LOCUS       NM_001436406            5162 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 5, mRNA.
ACCESSION   NM_001436406 XM_063266230
VERSION     NM_001436406.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5162)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5162)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5162)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5162)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_063266230.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.35513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1679           JAXUCZ010000008.1  70782800-70783001
            1680-1696           JAXUCZ010000008.1  70784419-70784435
            1697-1816           JAXUCZ010000008.1  70788295-70788414
            1817-1867           JAXUCZ010000008.1  70789262-70789312
            1868-2020           JAXUCZ010000008.1  70789717-70789869
            2021-2153           JAXUCZ010000008.1  70790230-70790362
            2154-2353           JAXUCZ010000008.1  70790810-70791009
            2354-2430           JAXUCZ010000008.1  70792121-70792197
            2431-2680           JAXUCZ010000008.1  70793078-70793327
            2681-2928           JAXUCZ010000008.1  70793690-70793937
            2929-3076           JAXUCZ010000008.1  70794731-70794878
            3077-3227           JAXUCZ010000008.1  70795421-70795571
            3228-3304           JAXUCZ010000008.1  70796240-70796316
            3305-5162           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5162
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3412
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 5 is encoded by transcript variant 5;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 5"
                     /protein_id="NP_001423335.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQLQAQHLSHATHGPPVQLPPHPSGL
                     QPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLR
                     ASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHS
                     PPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRND
                     APTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSP
                     SAYAGLHNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGG
                     KPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVY
                     TGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWD
                     LASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHT
                     DGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAV
                     GMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGAS
                     IFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1501
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1501
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1490..1591
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1496..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1652..2149
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1700..1906
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1709..1711
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1721..1723
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1733..1735
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1751..1753
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1775..1786
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1796..1798
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1820..1822
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1835..1837
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1853..2509
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1853..2509
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1877..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1889..1891
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1901..1903
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1925..1927
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1958..1960
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2051..2053
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2063..2065
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2084..2086
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2102..2104
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2330..2332
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2543..2659
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2546..3403
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2546..3403
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2558..2677
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2558..2677
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2681..2800
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2699..2815
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2699..2815
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2813..2932
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2828..2938
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2828..2938
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2939..3058
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2957..3064
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2957..3064
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3062..3181
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3077..3178
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3077..3178
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3185..3304
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3200..3304
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3200..3304
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3308..3406
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3323..3397
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3323..3397
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1679
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1816
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1867
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2020
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2153
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2353
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2430
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2680
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2928
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3076
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3227
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3304
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..5162
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag caactccagg cacagcacct
     1501 ctcccatgcc acacatggtc ccccggtcca gctgccaccc cacccgtcag gcctccaacc
     1561 tcctgggatt cccccagtga caggaagcag ctctgggttg ctggcacttg gtgccctggg
     1621 aagccaagcc cacttggcag tgaaggatga gaagaaccat catgaactgg atcacagaga
     1681 gagagagtcc agcacgaaca attctgtgtc accctcagaa agcctccggg ccagtgagaa
     1741 gcaccggggc tctgcagact acagcatgga agccaagaag cggaaagcgg aagagaaaga
     1801 cagcctgagc cgatacgaca gcgatgggga caagagtgat gacctggtag tggatgtctc
     1861 caatgaggac ccagcgacac cccgggtgag cccagcacac tcccctcctg aaaatgggct
     1921 ggacaaagcc cgaggtctga agaaagacgc ccccaccagc ccagcctctg tggcttcctc
     1981 cagcagcacg ccttcctcca agaccaaaga ccttggtcat aatgacaaat cttccacacc
     2041 tgggctcaag tccaacacac caacgccaag gaacgatgcc ccaactccag gcaccagcac
     2101 caccccgggg ctccggtcaa tgccgggcaa acctccaggc atggacccga tagcctcggc
     2161 cctgcgcaca cccatctccc tcaccagctc ctatgcagca ccctttgcca tgatgagcca
     2221 ccacgagatg aatggctccc tcaccagccc aagcgcctat gctggcctac acaacatccc
     2281 atcccagatg agcgccgccg cagcagctgc agccgccgcc tatggccgat cgccaatggt
     2341 gagctttgga gctgttggtt ttgaccctca tcccccgatg cgggccacag gcctgccctc
     2401 cagtcttgcc tccattcctg gagggaaacc ggcgtactcc ttccatgtga gtgccgacgg
     2461 gcagatgcaa cctgtgccct tcccccatga tgcgctagca ggccccggca ttcccaggca
     2521 tgcccggcag atcaacacac tcagccatgg ggaggtggta tgtgccgtga ccatcagcaa
     2581 ccccacgagg cacgtctaca caggcggcaa gggctgtgtg aagatatggg acatcagcca
     2641 gccgggcagc aagagtccca tctcccagct ggactgcctg aacagggaca actacatccg
     2701 ctcatgcaag cttctccctg atgggcgcac gctcattgtg ggtggtgagg ccagcacact
     2761 caccatctgg gacctggcct cgcccacgcc ccgcatcaag gctgagctga cgtcctcggc
     2821 tccagcctgt tacgccctgg ccatcagtcc tgatgccaaa gtctgtttct cctgctgcag
     2881 tgatgggaac attgcagttt gggatctgca caaccagacc ctggtcaggc agttccaggg
     2941 ccacacggat ggggccagct gtatagacat ctctcatgat ggcactaaac tgtggaccgg
     3001 gggcctggac aacactgtgc gctcctggga cctgcgtgaa gggcggcagc tacagcaaca
     3061 cgacttcacc tcccagatct tctccctggg ttactgcccc actggggagt ggctcgccgt
     3121 gggcatggag agcagcaacg tagaggttct gcaccacacc aagccggaca agtaccaact
     3181 gcatctgcac gagagctgcg tgctgtccct caagtttgcc tactgtggca agtggtttgt
     3241 gagcactggg aaagacaacc ttctcaatgc ctggaggacg ccttacggag ccagcatctt
     3301 ccagtctaaa gaatcctcgt ccgtcttgag ctgtgatatt tcagcggatg acaaatatat
     3361 tgtaacgggc tctggtgaca agaaggccac agtttacgag gtcatctact gaacaaggac
     3421 tctaagaggc ctgtcaaact ctgggagaca cccacgcggc cctgacaggg agatgctggc
     3481 caggccccga ggatggcaga agagtgaggg acagcattgt ggggctgccc tccggaaggt
     3541 ggagaggacg cacgcccctt tgtggattgc tgtgtctgac agacttgaag gactttctcc
     3601 tctccccctc accagtgctg gcagatgctt caattagatt tctctggagg cttctgcttt
     3661 cgtttcccac acagacaccc tcatgagtct ctgtctcttc ctcccctgtc tgatctgtcc
     3721 cctccctact ccgggttggg ggcatgctgg agtagacatt gttgtttctg gggaggggcg
     3781 cctcgttctg attgtgcagt gcacaaggtt tgtgaacaat gtaaataaga gactgtggtt
     3841 gctgactggc cagtgaggga ggaggcccct tcccaccagt gctcgccgtg tattttgcct
     3901 gctgtatttg taacccactc gcggtggtgg cttttctttc tttcttttct taagattttt
     3961 tttaaacaga tgttctgtgg ggaaagtagg cagagataga gagtcgggga gtggaatgag
     4021 aagcttcctg gggatgggca aaccagcctg gcccactggg actgaagtat atctccacac
     4081 gggttttagc accatcttca gatggaatga taggcagatg gacagacaag ctgatggaca
     4141 gacagtactg ggatgggcca gcttgggcta ttatccacag gaacagcgag gatttcctgt
     4201 gggtttctct gctccatctt ctcttgcctt gccctcacac ctcctgacct ccatctcttt
     4261 ctgcccccct ccccccgctc gcctctccca ctggacccca tctttctctt tggtgcacac
     4321 tcaatcattg tgatgaggaa tggaagttca agggaactcc ctctctgact ctcctccgcc
     4381 agcctagaaa ggattccata tgggggtggg agggagacaa gcgactcagc tcagggagct
     4441 accagagaaa aacagcaact ggtgtgggtg cttttttttt taatttgaat aaaaataatt
     4501 agaagtgata tcctttgata agatgccgtc tcccctttcc tgctctcagc cctttctgct
     4561 ccctgaagcc ggggatatgg tgacccccag ggtcgtaagt ctaagaagat gggcggggga
     4621 gcgggctggg ggctggggca gacggaatgt catctgcaga tatcacccct agggtaccaa
     4681 tgtttgtggt attaggtttg ctttgttttg ttttggtctt ttgttgtttt attaaagaaa
     4741 agctaaagac cgtgtgagcc ctgctggtgg gctttccatg gatgtagcat atggaagaga
     4801 gtttttatat tgcattttta tggattattt tataatgtgg gactcagtct gggaagaaag
     4861 atgagggtgt ctaaaacctg cccatctcca gtgctccaac tgagcggctg ccccgaacag
     4921 gatgtatgtt gggacatgga aagaccgtgg caccccgcac cttcctgaga ggcatgtcga
     4981 catgcctgtc tggagtctgt ccatctgtct ctgggtttca gatgatcact ggccaccact
     5041 tgttaaggct ctagccagaa gggagggtta gggtggaaga gagttattcc tgaagaaaaa
     5101 agaaaaattg aaacatcatt gtaatgaagc tttttatatt tttaaaagtt actatttaaa
     5161 aa
//
LOCUS       NM_001436393            2026 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus platelet derived growth factor subunit A (Pdgfa),
            transcript variant 1, mRNA.
ACCESSION   NM_001436393
VERSION     NM_001436393.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Rashid,F.N., Clayton,Z.E., Ogawa,M., Perdomo,J., Hume,R.D.,
            Kizana,E. and Chong,J.J.H.
  TITLE     Platelet derived growth factor-A (Pdgf-a) gene transfer modulates
            scar composition and improves left ventricular function after
            myocardial infarction
  JOURNAL   Int J Cardiol 341, 24-30 (2021)
   PUBMED   34265313
  REMARK    GeneRIF: Platelet derived growth factor-A (Pdgf-a) gene transfer
            modulates scar composition and improves left ventricular function
            after myocardial infarction.
REFERENCE   2  (bases 1 to 2026)
  AUTHORS   Connolly,N.P., Stokum,J.A., Schneider,C.S., Ozawa,T., Xu,S.,
            Galisteo,R., Castellani,R.J., Kim,A.J., Simard,J.M., Winkles,J.A.,
            Holland,E.C. and Woodworth,G.F.
  TITLE     Genetically engineered rat gliomas: PDGF-driven tumor initiation
            and progression in tv-a transgenic rats recreate key features of
            human brain cancer
  JOURNAL   PLoS One 12 (3), e0174557 (2017)
   PUBMED   28358926
  REMARK    GeneRIF: an Ntv-a transgenic rat colony was established and used to
            study glial brain tumors driven by two well-characterized oncogenic
            gene transformations, PDGFA overexpression and p53 depletion.
            Combined PDGFA and p53 alterations resulted in large, heterogeneous
            tumors in all affected animals
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2026)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   4  (bases 1 to 2026)
  AUTHORS   Shepherd,J.A., Stamper,E., Matheson,P.J., Galganski,L.,
            Garrison,R.N., Madden,K. and Downard,C.D.
  TITLE     Alterations in platelet-derived growth factor expression in the
            pathophysiology of necrotizing enterocolitis
  JOURNAL   J Surg Res 198 (2), 377-383 (2015)
   PUBMED   25899145
  REMARK    GeneRIF: expression altered in experimental Necrotizing
            enterocolitis
REFERENCE   5  (bases 1 to 2026)
  AUTHORS   Ha,J.M., Yun,S.J., Kim,Y.W., Jin,S.Y., Lee,H.S., Song,S.H.,
            Shin,H.K. and Bae,S.S.
  TITLE     Platelet-derived growth factor regulates vascular smooth muscle
            phenotype via mammalian target of rapamycin complex 1
  JOURNAL   Biochem Biophys Res Commun 464 (1), 57-62 (2015)
   PUBMED   26032503
  REMARK    GeneRIF: PDGF regulates vascular smooth muscle phenotype via
            mammalian target of rapamycin complex 1.
REFERENCE   6  (bases 1 to 2026)
  AUTHORS   Bryckaert,M.C., Rendu,F., Tobelem,G. and Wasteson,A.
  TITLE     Collagen-induced binding to human platelets of platelet-derived
            growth factor leading to inhibition of P43 and P20 phosphorylation
  JOURNAL   J Biol Chem 264 (8), 4336-4341 (1989)
   PUBMED   2538439
REFERENCE   7  (bases 1 to 2026)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
REFERENCE   8  (bases 1 to 2026)
  AUTHORS   Escobedo,J.A., Navankasatussas,S., Cousens,L.S., Coughlin,S.R.,
            Bell,G.I. and Williams,L.T.
  TITLE     A common PDGF receptor is activated by homodimeric A and B forms of
            PDGF
  JOURNAL   Science 240 (4858), 1532-1534 (1988)
   PUBMED   2836953
REFERENCE   9  (bases 1 to 2026)
  AUTHORS   Womer,R.B., Frick,K., Mitchell,C.D., Ross,A.H., Bishayee,S. and
            Scher,C.D.
  TITLE     PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma
            cells but does not stimulate cell replication
  JOURNAL   J Cell Physiol 132 (1), 65-72 (1987)
   PUBMED   2439522
REFERENCE   10 (bases 1 to 2026)
  AUTHORS   Heldin,C.H., Westermark,B. and Wasteson,A.
  TITLE     Platelet-derived growth factor: purification and partial
            characterization
  JOURNAL   Proc Natl Acad Sci U S A 76 (8), 3722-3726 (1979)
   PUBMED   291037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061731.1, SRR26643291.32143.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000012.1  20761808-20762043
            237-333             JAXUCZ010000012.1  20763365-20763461
            334-438             JAXUCZ010000012.1  20768458-20768562
            439-626             JAXUCZ010000012.1  20770718-20770905
            627-753             JAXUCZ010000012.1  20777995-20778121
            754-823             JAXUCZ010000012.1  20778562-20778631
            824-2026            JAXUCZ010000012.1  20780032-20781234
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2026
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="platelet derived growth factor subunit A"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
     exon            1..236
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..809
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PDGF subunit A; Platelet-derived growth factor
                     A chain; platelet derived growth factor, alpha;
                     platelet-derived growth factor alpha polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit A isoform
                     1 precursor"
                     /protein_id="NP_001423322.1"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
                     /translation="MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDL
                     QRLLEIDSVGAEDALETNLRAHGSHTVKHVPEKRPVPIRRKRSIEEAIPAVCKTRTVI
                     YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
                     KPKLKEVQVRLEEHLECACATSNLNPDHREEETGRRRESGKKRKRKRLKPT"
     sig_peptide     174..233
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    234..458
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     misc_feature    234..458
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     mat_peptide     429..785
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /product="Platelet-derived growth factor subunit A.
                     /id=PRO_0000023363"
                     /note="propagated from UniProtKB/Swiss-Prot (P28576.2)"
     misc_feature    453..716
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    453..716
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(453..464,570..572,576..587,630..641)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(453..464,570..572,576..587,630..641)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(459..461,558..560,570..572,591..593,702..704,
                     708..710)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(459..461,558..560,570..572,591..593,702..704,
                     708..710)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(540..542,567..569)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(540..542,567..569)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    573..575
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P28576.2); glycosylation site"
     misc_feature    645..659
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="propagated from UniProtKB/Swiss-Prot (P28576.2);
                     Region: Receptor binding site. /evidence=ECO:0000255"
     exon            237..333
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            334..438
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            439..626
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            627..753
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            754..823
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            824..2026
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcgcag ctcgcgccga gcgcgctccg caggctccct gctctccgcg ccaccctcct
       61 ccgggccgcg ctccctgagg gatggtactg aatttcgccg ccacaggagc ccggctggag
      121 cgcccgcccc gcggcctcgc ctccctgccg agcttccagc gcctcgggac gcgatgagga
      181 cctgggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgccctg gccgaggaag
      241 ccgagatacc ccgggagttg atcgagcgac tggctcgaag tcagatccac agcatccggg
      301 acctccagcg actcttggag atagactccg taggggctga ggatgccttg gagacaaacc
      361 tgagagccca tgggtcccac actgttaagc atgtgccgga gaagcggcct gtgcccatcc
      421 gcaggaagag aagtattgag gaagccattc ccgcagtttg caagaccagg acggtcattt
      481 acgagatacc tcggagccag gtggacccca catcggccaa cttcttgatc tggcccccat
      541 gtgtggaggt gaagcgctgc actggctgct gtaacaccag cagcgtcaag tgccagccct
      601 caagggtcca ccaccgcagt gtcaaggtgg ccaaagtgga gtatgtcagg aagaagccaa
      661 aattgaaaga ggtccaggtg aggttagagg agcacctgga gtgcgcatgc gcgacctcca
      721 acctgaaccc agaccatcgg gaggaggaga cgggaaggcg tagggaatca ggtaaaaagc
      781 ggaaaagaaa aaggttaaaa cccacctaag gcggcccgac cagatgtgag gtgagatgag
      841 ctggctgccc tctcccggga cacggatgta cgtggcgtgt gacattcctg aacatactat
      901 gtatggtgct tcattgccaa tgtgcgtgca gtctttgttc tcctccgtga aaaactgtgt
      961 ccgaggacaa agagacagtg tccgtttgtt cagtgtgaca tcaaagcaag tactgtagca
     1021 ctcggagaga cagtgagaaa gcttccttgt cacagagagc gaaaacaaaa ccacaaaaaa
     1081 gaaaaaaaaa aaaaacaaaa aaattaaaaa agaaaaaaaa aaaacaaaac cacacccaac
     1141 aacaaaaaaa ccccaccaga agaaacaaaa aaagactgaa gcgggcaaca gaagggccgc
     1201 cctgcaggac tgaccctcga gtggtggctg atgttggcca ccaccctgga ttctgcccgt
     1261 gggcacaggt gcttttcgcc aaggacgccc agaatgctac ctgccagctc tactaggtac
     1321 aggaactgaa cgaatgggag aagcccgcgg gcctggaagc caccgcctgg actgagtctg
     1381 cctgggaact tcctgatggc cttacgtgga atttcttttt tcttatcttt ttcttttttt
     1441 ttttttcctt tccttttatt tttttacacc atgaagtaat tgagcttctc ctttttattc
     1501 tctgcctagc cttttttttt tttttttttt aaatctcttg gatgacattt tcgttgataa
     1561 catgcacgag gctgctgtaa gttgggacag tgagacggtt attttttttt tcctagccaa
     1621 actaatgagg tgtattaaaa taaataccta cctatacatc atttccgatg cgcctctgcc
     1681 ttcctttaac atcttctagc ttaggtcatt tgagagaact atgagaatcg ctcagttttg
     1741 ggtctccctc cacccctagg gaccaccctc cattgctaaa cggcttctgc ggcagtgtgg
     1801 aaactcgact aagattattt tatagtaagc tgttgggttt cactgttaac cagaactgtg
     1861 tgtgtgtgtg tgtggtttcc ttgttttggt ttggttttgt aaaggtgaac tttgtatttt
     1921 taatattatc agtttatata cctgagagcc tgctatatat atattttttt tattttgaac
     1981 taaaaggaga aaaaaaaatc aacgaactta atgcacatca gatgca
//
LOCUS       NM_001436407            5159 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 6, mRNA.
ACCESSION   NM_001436407 XM_006243214
VERSION     NM_001436407.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5159)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5159)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5159)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5159)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243214.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.29582.1,
                                           SRR26643288.34034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1682           JAXUCZ010000008.1  70782797-70783001
            1683-1699           JAXUCZ010000008.1  70784419-70784435
            1700-1819           JAXUCZ010000008.1  70788295-70788414
            1820-1870           JAXUCZ010000008.1  70789262-70789312
            1871-2023           JAXUCZ010000008.1  70789717-70789869
            2024-2165           JAXUCZ010000008.1  70790230-70790371
            2166-2350           JAXUCZ010000008.1  70790810-70790994
            2351-2427           JAXUCZ010000008.1  70792121-70792197
            2428-2677           JAXUCZ010000008.1  70793078-70793327
            2678-2925           JAXUCZ010000008.1  70793690-70793937
            2926-3073           JAXUCZ010000008.1  70794731-70794878
            3074-3224           JAXUCZ010000008.1  70795421-70795571
            3225-3301           JAXUCZ010000008.1  70796240-70796316
            3302-5159           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5159
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3409
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 6 is encoded by transcript variant 6;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 6"
                     /protein_id="NP_001423336.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG
                     LQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESL
                     RASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAH
                     SPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRN
                     DAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGS
                     LTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGK
                     PAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYT
                     GGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDL
                     ASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTD
                     GASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVG
                     MESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI
                     FQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1493..1594
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1499..1702
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1655..2152
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1703..1909
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1712..1714
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1736..1738
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1754..1756
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1778..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1799..1801
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1823..1825
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1838..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1856..2506
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1856..2506
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1880..1882
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1892..1894
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1904..1906
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1928..1930
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1961..1963
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2039..2041
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2054..2056
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2060..2062
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2066..2068
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2087..2089
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2105..2107
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2342..2344
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2540..2656
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2543..3400
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2543..3400
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2555..2674
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2555..2674
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2678..2797
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2696..2812
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2696..2812
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2810..2929
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2825..2935
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2825..2935
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2936..3055
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2954..3061
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2954..3061
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3059..3178
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3074..3175
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3074..3175
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3182..3301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3197..3301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3197..3301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3305..3403
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3320..3394
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3320..3394
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1819
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1870
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2023
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2165
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2350
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2427
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2677
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2925
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3073
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3224
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..5159
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag cagcaactcc aggcacagca
     1501 cctctcccat gccacacatg gtcccccggt ccagctgcca ccccacccgt caggcctcca
     1561 acctcctggg attcccccag tgacaggaag cagctctggg ttgctggcac ttggtgccct
     1621 gggaagccaa gcccacttgg cagtgaagga tgagaagaac catcatgaac tggatcacag
     1681 agagagagag tccagcacga acaattctgt gtcaccctca gaaagcctcc gggccagtga
     1741 gaagcaccgg ggctctgcag actacagcat ggaagccaag aagcggaaag cggaagagaa
     1801 agacagcctg agccgatacg acagcgatgg ggacaagagt gatgacctgg tagtggatgt
     1861 ctccaatgag gacccagcga caccccgggt gagcccagca cactcccctc ctgaaaatgg
     1921 gctggacaaa gcccgaggtc tgaagaaaga cgcccccacc agcccagcct ctgtggcttc
     1981 ctccagcagc acgccttcct ccaagaccaa agaccttggt cataatgaca aatcttccac
     2041 acctgggctc aagtccaaca caccaacgcc aaggaacgat gccccaactc caggcaccag
     2101 caccaccccg gggctccggt caatgccggg caaacctcca ggcatggacc cgataggtat
     2161 aatggcctcg gccctgcgca cacccatctc cctcaccagc tcctatgcag caccctttgc
     2221 catgatgagc caccacgaga tgaatggctc cctcaccagc ccaagcgcct atgctggcct
     2281 acacaacatc ccatcccaga tgagcgccgc cgcagcagct gcagccgccg cctatggccg
     2341 atcgccaatg gttggttttg accctcatcc cccgatgcgg gccacaggcc tgccctccag
     2401 tcttgcctcc attcctggag ggaaaccggc gtactccttc catgtgagtg ccgacgggca
     2461 gatgcaacct gtgcccttcc cccatgatgc gctagcaggc cccggcattc ccaggcatgc
     2521 ccggcagatc aacacactca gccatgggga ggtggtatgt gccgtgacca tcagcaaccc
     2581 cacgaggcac gtctacacag gcggcaaggg ctgtgtgaag atatgggaca tcagccagcc
     2641 gggcagcaag agtcccatct cccagctgga ctgcctgaac agggacaact acatccgctc
     2701 atgcaagctt ctccctgatg ggcgcacgct cattgtgggt ggtgaggcca gcacactcac
     2761 catctgggac ctggcctcgc ccacgccccg catcaaggct gagctgacgt cctcggctcc
     2821 agcctgttac gccctggcca tcagtcctga tgccaaagtc tgtttctcct gctgcagtga
     2881 tgggaacatt gcagtttggg atctgcacaa ccagaccctg gtcaggcagt tccagggcca
     2941 cacggatggg gccagctgta tagacatctc tcatgatggc actaaactgt ggaccggggg
     3001 cctggacaac actgtgcgct cctgggacct gcgtgaaggg cggcagctac agcaacacga
     3061 cttcacctcc cagatcttct ccctgggtta ctgccccact ggggagtggc tcgccgtggg
     3121 catggagagc agcaacgtag aggttctgca ccacaccaag ccggacaagt accaactgca
     3181 tctgcacgag agctgcgtgc tgtccctcaa gtttgcctac tgtggcaagt ggtttgtgag
     3241 cactgggaaa gacaaccttc tcaatgcctg gaggacgcct tacggagcca gcatcttcca
     3301 gtctaaagaa tcctcgtccg tcttgagctg tgatatttca gcggatgaca aatatattgt
     3361 aacgggctct ggtgacaaga aggccacagt ttacgaggtc atctactgaa caaggactct
     3421 aagaggcctg tcaaactctg ggagacaccc acgcggccct gacagggaga tgctggccag
     3481 gccccgagga tggcagaaga gtgagggaca gcattgtggg gctgccctcc ggaaggtgga
     3541 gaggacgcac gcccctttgt ggattgctgt gtctgacaga cttgaaggac tttctcctct
     3601 ccccctcacc agtgctggca gatgcttcaa ttagatttct ctggaggctt ctgctttcgt
     3661 ttcccacaca gacaccctca tgagtctctg tctcttcctc ccctgtctga tctgtcccct
     3721 ccctactccg ggttgggggc atgctggagt agacattgtt gtttctgggg aggggcgcct
     3781 cgttctgatt gtgcagtgca caaggtttgt gaacaatgta aataagagac tgtggttgct
     3841 gactggccag tgagggagga ggccccttcc caccagtgct cgccgtgtat tttgcctgct
     3901 gtatttgtaa cccactcgcg gtggtggctt ttctttcttt cttttcttaa gatttttttt
     3961 aaacagatgt tctgtgggga aagtaggcag agatagagag tcggggagtg gaatgagaag
     4021 cttcctgggg atgggcaaac cagcctggcc cactgggact gaagtatatc tccacacggg
     4081 ttttagcacc atcttcagat ggaatgatag gcagatggac agacaagctg atggacagac
     4141 agtactggga tgggccagct tgggctatta tccacaggaa cagcgaggat ttcctgtggg
     4201 tttctctgct ccatcttctc ttgccttgcc ctcacacctc ctgacctcca tctctttctg
     4261 cccccctccc cccgctcgcc tctcccactg gaccccatct ttctctttgg tgcacactca
     4321 atcattgtga tgaggaatgg aagttcaagg gaactccctc tctgactctc ctccgccagc
     4381 ctagaaagga ttccatatgg gggtgggagg gagacaagcg actcagctca gggagctacc
     4441 agagaaaaac agcaactggt gtgggtgctt ttttttttaa tttgaataaa aataattaga
     4501 agtgatatcc tttgataaga tgccgtctcc cctttcctgc tctcagccct ttctgctccc
     4561 tgaagccggg gatatggtga cccccagggt cgtaagtcta agaagatggg cgggggagcg
     4621 ggctgggggc tggggcagac ggaatgtcat ctgcagatat cacccctagg gtaccaatgt
     4681 ttgtggtatt aggtttgctt tgttttgttt tggtcttttg ttgttttatt aaagaaaagc
     4741 taaagaccgt gtgagccctg ctggtgggct ttccatggat gtagcatatg gaagagagtt
     4801 tttatattgc atttttatgg attattttat aatgtgggac tcagtctggg aagaaagatg
     4861 agggtgtcta aaacctgccc atctccagtg ctccaactga gcggctgccc cgaacaggat
     4921 gtatgttggg acatggaaag accgtggcac cccgcacctt cctgagaggc atgtcgacat
     4981 gcctgtctgg agtctgtcca tctgtctctg ggtttcagat gatcactggc caccacttgt
     5041 taaggctcta gccagaaggg agggttaggg tggaagagag ttattcctga agaaaaaaga
     5101 aaaattgaaa catcattgta atgaagcttt ttatattttt aaaagttact atttaaaaa
//
LOCUS       NM_001436414            5117 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 13, mRNA.
ACCESSION   NM_001436414 XM_006243221
VERSION     NM_001436414.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5117)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5117)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5117)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5117)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243221.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.33957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1447           JAXUCZ010000008.1  70775659-70775733
            1448-1649           JAXUCZ010000008.1  70782800-70783001
            1650-1666           JAXUCZ010000008.1  70784419-70784435
            1667-1786           JAXUCZ010000008.1  70788295-70788414
            1787-1837           JAXUCZ010000008.1  70789262-70789312
            1838-1990           JAXUCZ010000008.1  70789717-70789869
            1991-2123           JAXUCZ010000008.1  70790230-70790362
            2124-2308           JAXUCZ010000008.1  70790810-70790994
            2309-2385           JAXUCZ010000008.1  70792121-70792197
            2386-2635           JAXUCZ010000008.1  70793078-70793327
            2636-2883           JAXUCZ010000008.1  70793690-70793937
            2884-3031           JAXUCZ010000008.1  70794731-70794878
            3032-3182           JAXUCZ010000008.1  70795421-70795571
            3183-3259           JAXUCZ010000008.1  70796240-70796316
            3260-5117           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5117
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3367
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 12 is encoded by transcript variant 13;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 12"
                     /protein_id="NP_001423343.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTG
                     SSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSAD
                     YSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKAR
                     GLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTP
                     GLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNIP
                     SQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQ
                     PVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQP
                     GSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSS
                     APACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKL
                     WTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKP
                     DKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDI
                     SADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1471
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1471
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1460..1561
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1466..1669
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1622..2119
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1670..1876
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1679..1681
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1691..1693
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1703..1705
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1721..1723
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1745..1756
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1766..1768
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1790..1792
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1805..1807
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1823..2464
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1823..2464
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1847..1849
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1859..1861
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1871..1873
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1877..2404
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: SP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1895..1897
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1928..1930
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2006..2008
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2021..2023
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2027..2029
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2033..2035
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2054..2056
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2072..2074
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2300..2302
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2498..2614
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2501..3358
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2501..3358
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2513..2632
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2513..2632
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2636..2755
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2654..2770
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2654..2770
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2768..2887
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2783..2893
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2783..2893
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2894..3013
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2912..3019
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2912..3019
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3017..3136
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3032..3133
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3032..3133
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3140..3259
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3155..3259
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3155..3259
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3263..3361
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3278..3352
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3278..3352
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1447
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1649
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1666
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1786
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1837
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1990
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2123
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2308
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2635
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2883
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3031
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3182
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3259
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..5117
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcgggcag caactccagg cacagcacct ctcccatgcc acacatggtc ccccggtcca
     1501 gctgccaccc cacccgtcag gcctccaacc tcctgggatt cccccagtga caggaagcag
     1561 ctctgggttg ctggcacttg gtgccctggg aagccaagcc cacttggcag tgaaggatga
     1621 gaagaaccat catgaactgg atcacagaga gagagagtcc agcacgaaca attctgtgtc
     1681 accctcagaa agcctccggg ccagtgagaa gcaccggggc tctgcagact acagcatgga
     1741 agccaagaag cggaaagcgg aagagaaaga cagcctgagc cgatacgaca gcgatgggga
     1801 caagagtgat gacctggtag tggatgtctc caatgaggac ccagcgacac cccgggtgag
     1861 cccagcacac tcccctcctg aaaatgggct ggacaaagcc cgaggtctga agaaagacgc
     1921 ccccaccagc ccagcctctg tggcttcctc cagcagcacg ccttcctcca agaccaaaga
     1981 ccttggtcat aatgacaaat cttccacacc tgggctcaag tccaacacac caacgccaag
     2041 gaacgatgcc ccaactccag gcaccagcac caccccgggg ctccggtcaa tgccgggcaa
     2101 acctccaggc atggacccga tagcctcggc cctgcgcaca cccatctccc tcaccagctc
     2161 ctatgcagca ccctttgcca tgatgagcca ccacgagatg aatggctccc tcaccagccc
     2221 aagcgcctat gctggcctac acaacatccc atcccagatg agcgccgccg cagcagctgc
     2281 agccgccgcc tatggccgat cgccaatggt tggttttgac cctcatcccc cgatgcgggc
     2341 cacaggcctg ccctccagtc ttgcctccat tcctggaggg aaaccggcgt actccttcca
     2401 tgtgagtgcc gacgggcaga tgcaacctgt gcccttcccc catgatgcgc tagcaggccc
     2461 cggcattccc aggcatgccc ggcagatcaa cacactcagc catggggagg tggtatgtgc
     2521 cgtgaccatc agcaacccca cgaggcacgt ctacacaggc ggcaagggct gtgtgaagat
     2581 atgggacatc agccagccgg gcagcaagag tcccatctcc cagctggact gcctgaacag
     2641 ggacaactac atccgctcat gcaagcttct ccctgatggg cgcacgctca ttgtgggtgg
     2701 tgaggccagc acactcacca tctgggacct ggcctcgccc acgccccgca tcaaggctga
     2761 gctgacgtcc tcggctccag cctgttacgc cctggccatc agtcctgatg ccaaagtctg
     2821 tttctcctgc tgcagtgatg ggaacattgc agtttgggat ctgcacaacc agaccctggt
     2881 caggcagttc cagggccaca cggatggggc cagctgtata gacatctctc atgatggcac
     2941 taaactgtgg accgggggcc tggacaacac tgtgcgctcc tgggacctgc gtgaagggcg
     3001 gcagctacag caacacgact tcacctccca gatcttctcc ctgggttact gccccactgg
     3061 ggagtggctc gccgtgggca tggagagcag caacgtagag gttctgcacc acaccaagcc
     3121 ggacaagtac caactgcatc tgcacgagag ctgcgtgctg tccctcaagt ttgcctactg
     3181 tggcaagtgg tttgtgagca ctgggaaaga caaccttctc aatgcctgga ggacgcctta
     3241 cggagccagc atcttccagt ctaaagaatc ctcgtccgtc ttgagctgtg atatttcagc
     3301 ggatgacaaa tatattgtaa cgggctctgg tgacaagaag gccacagttt acgaggtcat
     3361 ctactgaaca aggactctaa gaggcctgtc aaactctggg agacacccac gcggccctga
     3421 cagggagatg ctggccaggc cccgaggatg gcagaagagt gagggacagc attgtggggc
     3481 tgccctccgg aaggtggaga ggacgcacgc ccctttgtgg attgctgtgt ctgacagact
     3541 tgaaggactt tctcctctcc ccctcaccag tgctggcaga tgcttcaatt agatttctct
     3601 ggaggcttct gctttcgttt cccacacaga caccctcatg agtctctgtc tcttcctccc
     3661 ctgtctgatc tgtcccctcc ctactccggg ttgggggcat gctggagtag acattgttgt
     3721 ttctggggag gggcgcctcg ttctgattgt gcagtgcaca aggtttgtga acaatgtaaa
     3781 taagagactg tggttgctga ctggccagtg agggaggagg ccccttccca ccagtgctcg
     3841 ccgtgtattt tgcctgctgt atttgtaacc cactcgcggt ggtggctttt ctttctttct
     3901 tttcttaaga ttttttttaa acagatgttc tgtggggaaa gtaggcagag atagagagtc
     3961 ggggagtgga atgagaagct tcctggggat gggcaaacca gcctggccca ctgggactga
     4021 agtatatctc cacacgggtt ttagcaccat cttcagatgg aatgataggc agatggacag
     4081 acaagctgat ggacagacag tactgggatg ggccagcttg ggctattatc cacaggaaca
     4141 gcgaggattt cctgtgggtt tctctgctcc atcttctctt gccttgccct cacacctcct
     4201 gacctccatc tctttctgcc cccctccccc cgctcgcctc tcccactgga ccccatcttt
     4261 ctctttggtg cacactcaat cattgtgatg aggaatggaa gttcaaggga actccctctc
     4321 tgactctcct ccgccagcct agaaaggatt ccatatgggg gtgggaggga gacaagcgac
     4381 tcagctcagg gagctaccag agaaaaacag caactggtgt gggtgctttt ttttttaatt
     4441 tgaataaaaa taattagaag tgatatcctt tgataagatg ccgtctcccc tttcctgctc
     4501 tcagcccttt ctgctccctg aagccgggga tatggtgacc cccagggtcg taagtctaag
     4561 aagatgggcg ggggagcggg ctgggggctg gggcagacgg aatgtcatct gcagatatca
     4621 cccctagggt accaatgttt gtggtattag gtttgctttg ttttgttttg gtcttttgtt
     4681 gttttattaa agaaaagcta aagaccgtgt gagccctgct ggtgggcttt ccatggatgt
     4741 agcatatgga agagagtttt tatattgcat ttttatggat tattttataa tgtgggactc
     4801 agtctgggaa gaaagatgag ggtgtctaaa acctgcccat ctccagtgct ccaactgagc
     4861 ggctgccccg aacaggatgt atgttgggac atggaaagac cgtggcaccc cgcaccttcc
     4921 tgagaggcat gtcgacatgc ctgtctggag tctgtccatc tgtctctggg tttcagatga
     4981 tcactggcca ccacttgtta aggctctagc cagaagggag ggttagggtg gaagagagtt
     5041 attcctgaag aaaaaagaaa aattgaaaca tcattgtaat gaagcttttt atatttttaa
     5101 aagttactat ttaaaaa
//
LOCUS       NM_001436405            5165 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 4, mRNA.
ACCESSION   NM_001436405 XM_006243213
VERSION     NM_001436405.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5165)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5165)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5165)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5165)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243213.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28649.1,
                                           SRR26643294.32979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1682           JAXUCZ010000008.1  70782797-70783001
            1683-1699           JAXUCZ010000008.1  70784419-70784435
            1700-1819           JAXUCZ010000008.1  70788295-70788414
            1820-1870           JAXUCZ010000008.1  70789262-70789312
            1871-2023           JAXUCZ010000008.1  70789717-70789869
            2024-2156           JAXUCZ010000008.1  70790230-70790362
            2157-2356           JAXUCZ010000008.1  70790810-70791009
            2357-2433           JAXUCZ010000008.1  70792121-70792197
            2434-2683           JAXUCZ010000008.1  70793078-70793327
            2684-2931           JAXUCZ010000008.1  70793690-70793937
            2932-3079           JAXUCZ010000008.1  70794731-70794878
            3080-3230           JAXUCZ010000008.1  70795421-70795571
            3231-3307           JAXUCZ010000008.1  70796240-70796316
            3308-5165           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5165
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3415
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 4 is encoded by transcript variant 4;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 4"
                     /protein_id="NP_001423334.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG
                     LQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESL
                     RASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAH
                     SPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRN
                     DAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTS
                     PSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPG
                     GKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHV
                     YTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIW
                     DLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGH
                     TDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLA
                     VGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGA
                     SIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1493..1594
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1499..1702
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1655..2152
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1703..1909
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1712..1714
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1736..1738
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1754..1756
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1778..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1799..1801
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1823..1825
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1838..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1856..2512
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1856..2512
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1880..1882
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1892..1894
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1904..1906
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1928..1930
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1961..1963
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2039..2041
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2054..2056
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2060..2062
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2066..2068
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2087..2089
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2105..2107
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2333..2335
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2546..2662
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2549..3406
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2549..3406
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2561..2680
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2561..2680
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2684..2803
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2702..2818
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2702..2818
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2816..2935
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2831..2941
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2831..2941
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2942..3061
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2960..3067
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2960..3067
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3065..3184
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3080..3181
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3080..3181
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3188..3307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3203..3307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3203..3307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3311..3409
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3326..3400
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3326..3400
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1819
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1870
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2023
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2156
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2356
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2433
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2683
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2931
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3079
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3230
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..5165
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag cagcaactcc aggcacagca
     1501 cctctcccat gccacacatg gtcccccggt ccagctgcca ccccacccgt caggcctcca
     1561 acctcctggg attcccccag tgacaggaag cagctctggg ttgctggcac ttggtgccct
     1621 gggaagccaa gcccacttgg cagtgaagga tgagaagaac catcatgaac tggatcacag
     1681 agagagagag tccagcacga acaattctgt gtcaccctca gaaagcctcc gggccagtga
     1741 gaagcaccgg ggctctgcag actacagcat ggaagccaag aagcggaaag cggaagagaa
     1801 agacagcctg agccgatacg acagcgatgg ggacaagagt gatgacctgg tagtggatgt
     1861 ctccaatgag gacccagcga caccccgggt gagcccagca cactcccctc ctgaaaatgg
     1921 gctggacaaa gcccgaggtc tgaagaaaga cgcccccacc agcccagcct ctgtggcttc
     1981 ctccagcagc acgccttcct ccaagaccaa agaccttggt cataatgaca aatcttccac
     2041 acctgggctc aagtccaaca caccaacgcc aaggaacgat gccccaactc caggcaccag
     2101 caccaccccg gggctccggt caatgccggg caaacctcca ggcatggacc cgatagcctc
     2161 ggccctgcgc acacccatct ccctcaccag ctcctatgca gcaccctttg ccatgatgag
     2221 ccaccacgag atgaatggct ccctcaccag cccaagcgcc tatgctggcc tacacaacat
     2281 cccatcccag atgagcgccg ccgcagcagc tgcagccgcc gcctatggcc gatcgccaat
     2341 ggtgagcttt ggagctgttg gttttgaccc tcatcccccg atgcgggcca caggcctgcc
     2401 ctccagtctt gcctccattc ctggagggaa accggcgtac tccttccatg tgagtgccga
     2461 cgggcagatg caacctgtgc ccttccccca tgatgcgcta gcaggccccg gcattcccag
     2521 gcatgcccgg cagatcaaca cactcagcca tggggaggtg gtatgtgccg tgaccatcag
     2581 caaccccacg aggcacgtct acacaggcgg caagggctgt gtgaagatat gggacatcag
     2641 ccagccgggc agcaagagtc ccatctccca gctggactgc ctgaacaggg acaactacat
     2701 ccgctcatgc aagcttctcc ctgatgggcg cacgctcatt gtgggtggtg aggccagcac
     2761 actcaccatc tgggacctgg cctcgcccac gccccgcatc aaggctgagc tgacgtcctc
     2821 ggctccagcc tgttacgccc tggccatcag tcctgatgcc aaagtctgtt tctcctgctg
     2881 cagtgatggg aacattgcag tttgggatct gcacaaccag accctggtca ggcagttcca
     2941 gggccacacg gatggggcca gctgtataga catctctcat gatggcacta aactgtggac
     3001 cgggggcctg gacaacactg tgcgctcctg ggacctgcgt gaagggcggc agctacagca
     3061 acacgacttc acctcccaga tcttctccct gggttactgc cccactgggg agtggctcgc
     3121 cgtgggcatg gagagcagca acgtagaggt tctgcaccac accaagccgg acaagtacca
     3181 actgcatctg cacgagagct gcgtgctgtc cctcaagttt gcctactgtg gcaagtggtt
     3241 tgtgagcact gggaaagaca accttctcaa tgcctggagg acgccttacg gagccagcat
     3301 cttccagtct aaagaatcct cgtccgtctt gagctgtgat atttcagcgg atgacaaata
     3361 tattgtaacg ggctctggtg acaagaaggc cacagtttac gaggtcatct actgaacaag
     3421 gactctaaga ggcctgtcaa actctgggag acacccacgc ggccctgaca gggagatgct
     3481 ggccaggccc cgaggatggc agaagagtga gggacagcat tgtggggctg ccctccggaa
     3541 ggtggagagg acgcacgccc ctttgtggat tgctgtgtct gacagacttg aaggactttc
     3601 tcctctcccc ctcaccagtg ctggcagatg cttcaattag atttctctgg aggcttctgc
     3661 tttcgtttcc cacacagaca ccctcatgag tctctgtctc ttcctcccct gtctgatctg
     3721 tcccctccct actccgggtt gggggcatgc tggagtagac attgttgttt ctggggaggg
     3781 gcgcctcgtt ctgattgtgc agtgcacaag gtttgtgaac aatgtaaata agagactgtg
     3841 gttgctgact ggccagtgag ggaggaggcc ccttcccacc agtgctcgcc gtgtattttg
     3901 cctgctgtat ttgtaaccca ctcgcggtgg tggcttttct ttctttcttt tcttaagatt
     3961 ttttttaaac agatgttctg tggggaaagt aggcagagat agagagtcgg ggagtggaat
     4021 gagaagcttc ctggggatgg gcaaaccagc ctggcccact gggactgaag tatatctcca
     4081 cacgggtttt agcaccatct tcagatggaa tgataggcag atggacagac aagctgatgg
     4141 acagacagta ctgggatggg ccagcttggg ctattatcca caggaacagc gaggatttcc
     4201 tgtgggtttc tctgctccat cttctcttgc cttgccctca cacctcctga cctccatctc
     4261 tttctgcccc cctccccccg ctcgcctctc ccactggacc ccatctttct ctttggtgca
     4321 cactcaatca ttgtgatgag gaatggaagt tcaagggaac tccctctctg actctcctcc
     4381 gccagcctag aaaggattcc atatgggggt gggagggaga caagcgactc agctcaggga
     4441 gctaccagag aaaaacagca actggtgtgg gtgctttttt ttttaatttg aataaaaata
     4501 attagaagtg atatcctttg ataagatgcc gtctcccctt tcctgctctc agccctttct
     4561 gctccctgaa gccggggata tggtgacccc cagggtcgta agtctaagaa gatgggcggg
     4621 ggagcgggct gggggctggg gcagacggaa tgtcatctgc agatatcacc cctagggtac
     4681 caatgtttgt ggtattaggt ttgctttgtt ttgttttggt cttttgttgt tttattaaag
     4741 aaaagctaaa gaccgtgtga gccctgctgg tgggctttcc atggatgtag catatggaag
     4801 agagttttta tattgcattt ttatggatta ttttataatg tgggactcag tctgggaaga
     4861 aagatgaggg tgtctaaaac ctgcccatct ccagtgctcc aactgagcgg ctgccccgaa
     4921 caggatgtat gttgggacat ggaaagaccg tggcaccccg caccttcctg agaggcatgt
     4981 cgacatgcct gtctggagtc tgtccatctg tctctgggtt tcagatgatc actggccacc
     5041 acttgttaag gctctagcca gaagggaggg ttagggtgga agagagttat tcctgaagaa
     5101 aaaagaaaaa ttgaaacatc attgtaatga agctttttat atttttaaaa gttactattt
     5161 aaaaa
//
LOCUS       NM_001436412            5129 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 11, mRNA.
ACCESSION   NM_001436412 XM_006243219
VERSION     NM_001436412.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5129)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5129)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5129)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5129)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243219.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.31486.1,
                                           SRR26643297.28653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1447           JAXUCZ010000008.1  70775659-70775733
            1448-1652           JAXUCZ010000008.1  70782797-70783001
            1653-1669           JAXUCZ010000008.1  70784419-70784435
            1670-1789           JAXUCZ010000008.1  70788295-70788414
            1790-1840           JAXUCZ010000008.1  70789262-70789312
            1841-1993           JAXUCZ010000008.1  70789717-70789869
            1994-2135           JAXUCZ010000008.1  70790230-70790371
            2136-2320           JAXUCZ010000008.1  70790810-70790994
            2321-2397           JAXUCZ010000008.1  70792121-70792197
            2398-2647           JAXUCZ010000008.1  70793078-70793327
            2648-2895           JAXUCZ010000008.1  70793690-70793937
            2896-3043           JAXUCZ010000008.1  70794731-70794878
            3044-3194           JAXUCZ010000008.1  70795421-70795571
            3195-3271           JAXUCZ010000008.1  70796240-70796316
            3272-5129           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5129
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3379
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 11 is encoded by transcript variant 11;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 11"
                     /protein_id="NP_001423341.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGL
                     HNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSAD
                     GQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWD
                     ISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAE
                     LTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHD
                     GTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH
                     HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL
                     SCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1076..1468
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1463..1564
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1469..1672
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1625..2122
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1673..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1682..1684
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1694..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1706..1708
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1748..1759
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1769..1771
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1793..1795
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1808..1810
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1826..2476
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1826..2476
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1850..1852
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1862..1864
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1874..1876
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1898..1900
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1931..1933
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2009..2011
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2024..2026
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2030..2032
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2075..2077
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2312..2314
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2510..2626
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2513..3370
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2513..3370
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2525..2644
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2525..2644
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2648..2767
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2666..2782
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2666..2782
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2780..2899
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2795..2905
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2795..2905
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2906..3025
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2924..3031
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2924..3031
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3029..3148
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3044..3145
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3044..3145
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3152..3271
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3167..3271
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3167..3271
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3275..3373
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3290..3364
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3290..3364
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1447
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1652
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1669
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1993
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2135
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2320
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2397
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2647
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2895
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3043
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3194
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3271
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..5129
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcgggcag cagcaactcc aggcacagca cctctcccat gccacacatg gtcccccggt
     1501 ccagctgcca ccccacccgt caggcctcca acctcctggg attcccccag tgacaggaag
     1561 cagctctggg ttgctggcac ttggtgccct gggaagccaa gcccacttgg cagtgaagga
     1621 tgagaagaac catcatgaac tggatcacag agagagagag tccagcacga acaattctgt
     1681 gtcaccctca gaaagcctcc gggccagtga gaagcaccgg ggctctgcag actacagcat
     1741 ggaagccaag aagcggaaag cggaagagaa agacagcctg agccgatacg acagcgatgg
     1801 ggacaagagt gatgacctgg tagtggatgt ctccaatgag gacccagcga caccccgggt
     1861 gagcccagca cactcccctc ctgaaaatgg gctggacaaa gcccgaggtc tgaagaaaga
     1921 cgcccccacc agcccagcct ctgtggcttc ctccagcagc acgccttcct ccaagaccaa
     1981 agaccttggt cataatgaca aatcttccac acctgggctc aagtccaaca caccaacgcc
     2041 aaggaacgat gccccaactc caggcaccag caccaccccg gggctccggt caatgccggg
     2101 caaacctcca ggcatggacc cgataggtat aatggcctcg gccctgcgca cacccatctc
     2161 cctcaccagc tcctatgcag caccctttgc catgatgagc caccacgaga tgaatggctc
     2221 cctcaccagc ccaagcgcct atgctggcct acacaacatc ccatcccaga tgagcgccgc
     2281 cgcagcagct gcagccgccg cctatggccg atcgccaatg gttggttttg accctcatcc
     2341 cccgatgcgg gccacaggcc tgccctccag tcttgcctcc attcctggag ggaaaccggc
     2401 gtactccttc catgtgagtg ccgacgggca gatgcaacct gtgcccttcc cccatgatgc
     2461 gctagcaggc cccggcattc ccaggcatgc ccggcagatc aacacactca gccatgggga
     2521 ggtggtatgt gccgtgacca tcagcaaccc cacgaggcac gtctacacag gcggcaaggg
     2581 ctgtgtgaag atatgggaca tcagccagcc gggcagcaag agtcccatct cccagctgga
     2641 ctgcctgaac agggacaact acatccgctc atgcaagctt ctccctgatg ggcgcacgct
     2701 cattgtgggt ggtgaggcca gcacactcac catctgggac ctggcctcgc ccacgccccg
     2761 catcaaggct gagctgacgt cctcggctcc agcctgttac gccctggcca tcagtcctga
     2821 tgccaaagtc tgtttctcct gctgcagtga tgggaacatt gcagtttggg atctgcacaa
     2881 ccagaccctg gtcaggcagt tccagggcca cacggatggg gccagctgta tagacatctc
     2941 tcatgatggc actaaactgt ggaccggggg cctggacaac actgtgcgct cctgggacct
     3001 gcgtgaaggg cggcagctac agcaacacga cttcacctcc cagatcttct ccctgggtta
     3061 ctgccccact ggggagtggc tcgccgtggg catggagagc agcaacgtag aggttctgca
     3121 ccacaccaag ccggacaagt accaactgca tctgcacgag agctgcgtgc tgtccctcaa
     3181 gtttgcctac tgtggcaagt ggtttgtgag cactgggaaa gacaaccttc tcaatgcctg
     3241 gaggacgcct tacggagcca gcatcttcca gtctaaagaa tcctcgtccg tcttgagctg
     3301 tgatatttca gcggatgaca aatatattgt aacgggctct ggtgacaaga aggccacagt
     3361 ttacgaggtc atctactgaa caaggactct aagaggcctg tcaaactctg ggagacaccc
     3421 acgcggccct gacagggaga tgctggccag gccccgagga tggcagaaga gtgagggaca
     3481 gcattgtggg gctgccctcc ggaaggtgga gaggacgcac gcccctttgt ggattgctgt
     3541 gtctgacaga cttgaaggac tttctcctct ccccctcacc agtgctggca gatgcttcaa
     3601 ttagatttct ctggaggctt ctgctttcgt ttcccacaca gacaccctca tgagtctctg
     3661 tctcttcctc ccctgtctga tctgtcccct ccctactccg ggttgggggc atgctggagt
     3721 agacattgtt gtttctgggg aggggcgcct cgttctgatt gtgcagtgca caaggtttgt
     3781 gaacaatgta aataagagac tgtggttgct gactggccag tgagggagga ggccccttcc
     3841 caccagtgct cgccgtgtat tttgcctgct gtatttgtaa cccactcgcg gtggtggctt
     3901 ttctttcttt cttttcttaa gatttttttt aaacagatgt tctgtgggga aagtaggcag
     3961 agatagagag tcggggagtg gaatgagaag cttcctgggg atgggcaaac cagcctggcc
     4021 cactgggact gaagtatatc tccacacggg ttttagcacc atcttcagat ggaatgatag
     4081 gcagatggac agacaagctg atggacagac agtactggga tgggccagct tgggctatta
     4141 tccacaggaa cagcgaggat ttcctgtggg tttctctgct ccatcttctc ttgccttgcc
     4201 ctcacacctc ctgacctcca tctctttctg cccccctccc cccgctcgcc tctcccactg
     4261 gaccccatct ttctctttgg tgcacactca atcattgtga tgaggaatgg aagttcaagg
     4321 gaactccctc tctgactctc ctccgccagc ctagaaagga ttccatatgg gggtgggagg
     4381 gagacaagcg actcagctca gggagctacc agagaaaaac agcaactggt gtgggtgctt
     4441 ttttttttaa tttgaataaa aataattaga agtgatatcc tttgataaga tgccgtctcc
     4501 cctttcctgc tctcagccct ttctgctccc tgaagccggg gatatggtga cccccagggt
     4561 cgtaagtcta agaagatggg cgggggagcg ggctgggggc tggggcagac ggaatgtcat
     4621 ctgcagatat cacccctagg gtaccaatgt ttgtggtatt aggtttgctt tgttttgttt
     4681 tggtcttttg ttgttttatt aaagaaaagc taaagaccgt gtgagccctg ctggtgggct
     4741 ttccatggat gtagcatatg gaagagagtt tttatattgc atttttatgg attattttat
     4801 aatgtgggac tcagtctggg aagaaagatg agggtgtcta aaacctgccc atctccagtg
     4861 ctccaactga gcggctgccc cgaacaggat gtatgttggg acatggaaag accgtggcac
     4921 cccgcacctt cctgagaggc atgtcgacat gcctgtctgg agtctgtcca tctgtctctg
     4981 ggtttcagat gatcactggc caccacttgt taaggctcta gccagaaggg agggttaggg
     5041 tggaagagag ttattcctga agaaaaaaga aaaattgaaa catcattgta atgaagcttt
     5101 ttatattttt aaaagttact atttaaaaa
//
LOCUS       NM_053400               5120 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 2, mRNA.
ACCESSION   NM_053400
VERSION     NM_053400.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5120)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5120)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5120)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5120)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced NM_053400.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186092.1, SRR26643299.35512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1447           JAXUCZ010000008.1  70775659-70775733
            1448-1652           JAXUCZ010000008.1  70782797-70783001
            1653-1669           JAXUCZ010000008.1  70784419-70784435
            1670-1789           JAXUCZ010000008.1  70788295-70788414
            1790-1840           JAXUCZ010000008.1  70789262-70789312
            1841-1993           JAXUCZ010000008.1  70789717-70789869
            1994-2126           JAXUCZ010000008.1  70790230-70790362
            2127-2311           JAXUCZ010000008.1  70790810-70790994
            2312-2388           JAXUCZ010000008.1  70792121-70792197
            2389-2638           JAXUCZ010000008.1  70793078-70793327
            2639-2886           JAXUCZ010000008.1  70793690-70793937
            2887-3034           JAXUCZ010000008.1  70794731-70794878
            3035-3185           JAXUCZ010000008.1  70795421-70795571
            3186-3262           JAXUCZ010000008.1  70796240-70796316
            3263-5120           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5120
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3370
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 2"
                     /protein_id="NP_445852.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNI
                     PSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQM
                     QPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQ
                     PGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTS
                     SAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTK
                     LWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTK
                     PDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD
                     ISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1076..1468
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1463..1564
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1469..1672
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1625..2122
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1673..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1682..1684
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1694..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1706..1708
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1748..1759
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1769..1771
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1793..1795
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1808..1810
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1826..2467
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1826..2467
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1850..1852
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1862..1864
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1874..1876
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1880..2407
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: SP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1898..1900
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1931..1933
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2009..2011
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2024..2026
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2030..2032
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2075..2077
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2303..2305
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2501..2617
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2504..3361
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2504..3361
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2516..2635
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2516..2635
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2639..2758
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2657..2773
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2657..2773
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2771..2890
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2786..2896
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2786..2896
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2897..3016
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2915..3022
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2915..3022
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3020..3139
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3035..3136
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3035..3136
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3143..3262
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3158..3262
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3158..3262
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3266..3364
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3281..3355
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3281..3355
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1447
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1652
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1669
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1993
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2126
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2311
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2388
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2638
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2886
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3034
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3185
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3262
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..5120
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcgggcag cagcaactcc aggcacagca cctctcccat gccacacatg gtcccccggt
     1501 ccagctgcca ccccacccgt caggcctcca acctcctggg attcccccag tgacaggaag
     1561 cagctctggg ttgctggcac ttggtgccct gggaagccaa gcccacttgg cagtgaagga
     1621 tgagaagaac catcatgaac tggatcacag agagagagag tccagcacga acaattctgt
     1681 gtcaccctca gaaagcctcc gggccagtga gaagcaccgg ggctctgcag actacagcat
     1741 ggaagccaag aagcggaaag cggaagagaa agacagcctg agccgatacg acagcgatgg
     1801 ggacaagagt gatgacctgg tagtggatgt ctccaatgag gacccagcga caccccgggt
     1861 gagcccagca cactcccctc ctgaaaatgg gctggacaaa gcccgaggtc tgaagaaaga
     1921 cgcccccacc agcccagcct ctgtggcttc ctccagcagc acgccttcct ccaagaccaa
     1981 agaccttggt cataatgaca aatcttccac acctgggctc aagtccaaca caccaacgcc
     2041 aaggaacgat gccccaactc caggcaccag caccaccccg gggctccggt caatgccggg
     2101 caaacctcca ggcatggacc cgatagcctc ggccctgcgc acacccatct ccctcaccag
     2161 ctcctatgca gcaccctttg ccatgatgag ccaccacgag atgaatggct ccctcaccag
     2221 cccaagcgcc tatgctggcc tacacaacat cccatcccag atgagcgccg ccgcagcagc
     2281 tgcagccgcc gcctatggcc gatcgccaat ggttggtttt gaccctcatc ccccgatgcg
     2341 ggccacaggc ctgccctcca gtcttgcctc cattcctgga gggaaaccgg cgtactcctt
     2401 ccatgtgagt gccgacgggc agatgcaacc tgtgcccttc ccccatgatg cgctagcagg
     2461 ccccggcatt cccaggcatg cccggcagat caacacactc agccatgggg aggtggtatg
     2521 tgccgtgacc atcagcaacc ccacgaggca cgtctacaca ggcggcaagg gctgtgtgaa
     2581 gatatgggac atcagccagc cgggcagcaa gagtcccatc tcccagctgg actgcctgaa
     2641 cagggacaac tacatccgct catgcaagct tctccctgat gggcgcacgc tcattgtggg
     2701 tggtgaggcc agcacactca ccatctggga cctggcctcg cccacgcccc gcatcaaggc
     2761 tgagctgacg tcctcggctc cagcctgtta cgccctggcc atcagtcctg atgccaaagt
     2821 ctgtttctcc tgctgcagtg atgggaacat tgcagtttgg gatctgcaca accagaccct
     2881 ggtcaggcag ttccagggcc acacggatgg ggccagctgt atagacatct ctcatgatgg
     2941 cactaaactg tggaccgggg gcctggacaa cactgtgcgc tcctgggacc tgcgtgaagg
     3001 gcggcagcta cagcaacacg acttcacctc ccagatcttc tccctgggtt actgccccac
     3061 tggggagtgg ctcgccgtgg gcatggagag cagcaacgta gaggttctgc accacaccaa
     3121 gccggacaag taccaactgc atctgcacga gagctgcgtg ctgtccctca agtttgccta
     3181 ctgtggcaag tggtttgtga gcactgggaa agacaacctt ctcaatgcct ggaggacgcc
     3241 ttacggagcc agcatcttcc agtctaaaga atcctcgtcc gtcttgagct gtgatatttc
     3301 agcggatgac aaatatattg taacgggctc tggtgacaag aaggccacag tttacgaggt
     3361 catctactga acaaggactc taagaggcct gtcaaactct gggagacacc cacgcggccc
     3421 tgacagggag atgctggcca ggccccgagg atggcagaag agtgagggac agcattgtgg
     3481 ggctgccctc cggaaggtgg agaggacgca cgcccctttg tggattgctg tgtctgacag
     3541 acttgaagga ctttctcctc tccccctcac cagtgctggc agatgcttca attagatttc
     3601 tctggaggct tctgctttcg tttcccacac agacaccctc atgagtctct gtctcttcct
     3661 cccctgtctg atctgtcccc tccctactcc gggttggggg catgctggag tagacattgt
     3721 tgtttctggg gaggggcgcc tcgttctgat tgtgcagtgc acaaggtttg tgaacaatgt
     3781 aaataagaga ctgtggttgc tgactggcca gtgagggagg aggccccttc ccaccagtgc
     3841 tcgccgtgta ttttgcctgc tgtatttgta acccactcgc ggtggtggct tttctttctt
     3901 tcttttctta agattttttt taaacagatg ttctgtgggg aaagtaggca gagatagaga
     3961 gtcggggagt ggaatgagaa gcttcctggg gatgggcaaa ccagcctggc ccactgggac
     4021 tgaagtatat ctccacacgg gttttagcac catcttcaga tggaatgata ggcagatgga
     4081 cagacaagct gatggacaga cagtactggg atgggccagc ttgggctatt atccacagga
     4141 acagcgagga tttcctgtgg gtttctctgc tccatcttct cttgccttgc cctcacacct
     4201 cctgacctcc atctctttct gcccccctcc ccccgctcgc ctctcccact ggaccccatc
     4261 tttctctttg gtgcacactc aatcattgtg atgaggaatg gaagttcaag ggaactccct
     4321 ctctgactct cctccgccag cctagaaagg attccatatg ggggtgggag ggagacaagc
     4381 gactcagctc agggagctac cagagaaaaa cagcaactgg tgtgggtgct ttttttttta
     4441 atttgaataa aaataattag aagtgatatc ctttgataag atgccgtctc ccctttcctg
     4501 ctctcagccc tttctgctcc ctgaagccgg ggatatggtg acccccaggg tcgtaagtct
     4561 aagaagatgg gcgggggagc gggctggggg ctggggcaga cggaatgtca tctgcagata
     4621 tcacccctag ggtaccaatg tttgtggtat taggtttgct ttgttttgtt ttggtctttt
     4681 gttgttttat taaagaaaag ctaaagaccg tgtgagccct gctggtgggc tttccatgga
     4741 tgtagcatat ggaagagagt ttttatattg catttttatg gattatttta taatgtggga
     4801 ctcagtctgg gaagaaagat gagggtgtct aaaacctgcc catctccagt gctccaactg
     4861 agcggctgcc ccgaacagga tgtatgttgg gacatggaaa gaccgtggca ccccgcacct
     4921 tcctgagagg catgtcgaca tgcctgtctg gagtctgtcc atctgtctct gggtttcaga
     4981 tgatcactgg ccaccacttg ttaaggctct agccagaagg gagggttagg gtggaagaga
     5041 gttattcctg aagaaaaaag aaaaattgaa acatcattgt aatgaagctt tttatatttt
     5101 taaaagttac tatttaaaaa
//
LOCUS       NM_001436411            4960 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 10, mRNA.
ACCESSION   NM_001436411 XM_063266232
VERSION     NM_001436411.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4960)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4960)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 4960)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 4960)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_063266232.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28652.1,
                                           SRR26643299.35515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000008.1  70753436-70753516
            82-924              JAXUCZ010000008.1  70753692-70754534
            925-1025            JAXUCZ010000008.1  70755028-70755128
            1026-1089           JAXUCZ010000008.1  70755588-70755651
            1090-1134           JAXUCZ010000008.1  70756612-70756656
            1135-1197           JAXUCZ010000008.1  70774229-70774291
            1198-1272           JAXUCZ010000008.1  70775659-70775733
            1273-1477           JAXUCZ010000008.1  70782797-70783001
            1478-1494           JAXUCZ010000008.1  70784419-70784435
            1495-1614           JAXUCZ010000008.1  70788295-70788414
            1615-1665           JAXUCZ010000008.1  70789262-70789312
            1666-1818           JAXUCZ010000008.1  70789717-70789869
            1819-1951           JAXUCZ010000008.1  70790230-70790362
            1952-2151           JAXUCZ010000008.1  70790810-70791009
            2152-2228           JAXUCZ010000008.1  70792121-70792197
            2229-2478           JAXUCZ010000008.1  70793078-70793327
            2479-2726           JAXUCZ010000008.1  70793690-70793937
            2727-2874           JAXUCZ010000008.1  70794731-70794878
            2875-3025           JAXUCZ010000008.1  70795421-70795571
            3026-3102           JAXUCZ010000008.1  70796240-70796316
            3103-4960           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..4960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4960
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..81
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            82..924
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    505..507
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             901..3210
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 1 is encoded by transcript variant 10;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 1"
                     /protein_id="NP_001423340.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNI
                     PSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVS
                     ADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKI
                     WDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIK
                     AELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS
                     HDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV
                     LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSS
                     VLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    901..1293
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    952..1299
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    952..1299
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1288..1389
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1497
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1450..1947
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1498..1704
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1507..1509
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1519..1521
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1531..1533
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1549..1551
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1573..1584
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1594..1596
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1618..1620
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1633..1635
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1651..2307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1651..2307
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1675..1677
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1687..1689
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1699..1701
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1723..1725
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1756..1758
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1834..1836
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1849..1851
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1855..1857
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1861..1863
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1882..1884
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1900..1902
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2128..2130
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2341..2457
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2344..3201
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2344..3201
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2356..2475
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2356..2475
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2479..2598
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2497..2613
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2497..2613
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2611..2730
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2626..2736
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2626..2736
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2737..2856
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2755..2862
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2755..2862
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2860..2979
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    2875..2976
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2875..2976
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2983..3102
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    2998..3102
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2998..3102
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3106..3204
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3121..3195
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3121..3195
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            925..1025
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1089
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1134
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1197
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1272
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1494
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1614
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1665
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1818
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1951
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2151
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2228
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2478
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2874
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3025
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3102
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..4960
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca gcctgcgcgc tcctaggcag cagggacgcc gaccgctccc
      121 cgccggagac gcagccgatt cacttgagag caaagaagac cccttcgccg aggcttccta
      181 tgccggctgg agttaggatg ccacggccca ttatttgcac cgactaaccc ggagttcctc
      241 ctcggccctg ggaaggactg gcggcggcgg ctggagcaga cagagcagca ggctctcttc
      301 tccgagggga ggggggggcg tcgaagcgcc ctcgctgggc tctagccctc acccacggtc
      361 ctcaagccgt cacctcggtg gcctgcttcc tttttcttct ccccgcgact ccgggcccga
      421 ccgcctctgg gatttgaccc gcgcgccccg gatgctccga gctgcccaga cgcgcccccc
      481 cccctccagc ctcatcgtgc tgattgaccc gtgaggggac aagagaaacc caccccccaa
      541 cctccgggcc tcgggatcct gctctggagc tgccagggag ccgatgatgt ccacgcagac
      601 ccggcttctg acactgtcca cgcagccggg ggaaggtggc cggccgcagc cggccgagcc
      661 ttaggcgcac aaagcgcgag cccgccgacg actttgccgc tcgctccgcc gctctttgtc
      721 tgcacttggg gcgcacgccc gactctggga tttcgctgcg agagcgggct gggggggccg
      781 ggggcgagct ctcggttccc cggccgcccc ccgctcgggc tcgcctcccc cctcccccgc
      841 acgtccccgg ctcgggctct cagcgcttcc aagctctcgg aatcgcgacc cctccctgcc
      901 atgtatccgc aaggcagaca tccggcaccc catcaacccg ggcagccagg atttaaattc
      961 actgtggccg agtcctgtga caggatcaaa gacgaattcc agttcctgca agctcagtat
     1021 cacagcctca aagtggagta cgacaagctg gcgaacgaga agacagagat gcagcgccat
     1081 tatgtgatgt actatgagat gtcctacggc ttgaatatcg aaatgcacaa gcagacagag
     1141 atcgcgaaga gactgaacac gattctagcc cagatcatgc cttttttgtc acaggagcat
     1201 cagcagcaag tggcgcaggc tgtggaacgc gccaagcagg tcaccatgac ggagctgaac
     1261 gccatcatcg ggcagcagca actccaggca cagcacctct cccatgccac acatggtccc
     1321 ccggtccagc tgccacccca cccgtcaggc ctccaacctc ctgggattcc cccagtgaca
     1381 ggaagcagct ctgggttgct ggcacttggt gccctgggaa gccaagccca cttggcagtg
     1441 aaggatgaga agaaccatca tgaactggat cacagagaga gagagtccag cacgaacaat
     1501 tctgtgtcac cctcagaaag cctccgggcc agtgagaagc accggggctc tgcagactac
     1561 agcatggaag ccaagaagcg gaaagcggaa gagaaagaca gcctgagccg atacgacagc
     1621 gatggggaca agagtgatga cctggtagtg gatgtctcca atgaggaccc agcgacaccc
     1681 cgggtgagcc cagcacactc ccctcctgaa aatgggctgg acaaagcccg aggtctgaag
     1741 aaagacgccc ccaccagccc agcctctgtg gcttcctcca gcagcacgcc ttcctccaag
     1801 accaaagacc ttggtcataa tgacaaatct tccacacctg ggctcaagtc caacacacca
     1861 acgccaagga acgatgcccc aactccaggc accagcacca ccccggggct ccggtcaatg
     1921 ccgggcaaac ctccaggcat ggacccgata gcctcggccc tgcgcacacc catctccctc
     1981 accagctcct atgcagcacc ctttgccatg atgagccacc acgagatgaa tggctccctc
     2041 accagcccaa gcgcctatgc tggcctacac aacatcccat cccagatgag cgccgccgca
     2101 gcagctgcag ccgccgccta tggccgatcg ccaatggtga gctttggagc tgttggtttt
     2161 gaccctcatc ccccgatgcg ggccacaggc ctgccctcca gtcttgcctc cattcctgga
     2221 gggaaaccgg cgtactcctt ccatgtgagt gccgacgggc agatgcaacc tgtgcccttc
     2281 ccccatgatg cgctagcagg ccccggcatt cccaggcatg cccggcagat caacacactc
     2341 agccatgggg aggtggtatg tgccgtgacc atcagcaacc ccacgaggca cgtctacaca
     2401 ggcggcaagg gctgtgtgaa gatatgggac atcagccagc cgggcagcaa gagtcccatc
     2461 tcccagctgg actgcctgaa cagggacaac tacatccgct catgcaagct tctccctgat
     2521 gggcgcacgc tcattgtggg tggtgaggcc agcacactca ccatctggga cctggcctcg
     2581 cccacgcccc gcatcaaggc tgagctgacg tcctcggctc cagcctgtta cgccctggcc
     2641 atcagtcctg atgccaaagt ctgtttctcc tgctgcagtg atgggaacat tgcagtttgg
     2701 gatctgcaca accagaccct ggtcaggcag ttccagggcc acacggatgg ggccagctgt
     2761 atagacatct ctcatgatgg cactaaactg tggaccgggg gcctggacaa cactgtgcgc
     2821 tcctgggacc tgcgtgaagg gcggcagcta cagcaacacg acttcacctc ccagatcttc
     2881 tccctgggtt actgccccac tggggagtgg ctcgccgtgg gcatggagag cagcaacgta
     2941 gaggttctgc accacaccaa gccggacaag taccaactgc atctgcacga gagctgcgtg
     3001 ctgtccctca agtttgccta ctgtggcaag tggtttgtga gcactgggaa agacaacctt
     3061 ctcaatgcct ggaggacgcc ttacggagcc agcatcttcc agtctaaaga atcctcgtcc
     3121 gtcttgagct gtgatatttc agcggatgac aaatatattg taacgggctc tggtgacaag
     3181 aaggccacag tttacgaggt catctactga acaaggactc taagaggcct gtcaaactct
     3241 gggagacacc cacgcggccc tgacagggag atgctggcca ggccccgagg atggcagaag
     3301 agtgagggac agcattgtgg ggctgccctc cggaaggtgg agaggacgca cgcccctttg
     3361 tggattgctg tgtctgacag acttgaagga ctttctcctc tccccctcac cagtgctggc
     3421 agatgcttca attagatttc tctggaggct tctgctttcg tttcccacac agacaccctc
     3481 atgagtctct gtctcttcct cccctgtctg atctgtcccc tccctactcc gggttggggg
     3541 catgctggag tagacattgt tgtttctggg gaggggcgcc tcgttctgat tgtgcagtgc
     3601 acaaggtttg tgaacaatgt aaataagaga ctgtggttgc tgactggcca gtgagggagg
     3661 aggccccttc ccaccagtgc tcgccgtgta ttttgcctgc tgtatttgta acccactcgc
     3721 ggtggtggct tttctttctt tcttttctta agattttttt taaacagatg ttctgtgggg
     3781 aaagtaggca gagatagaga gtcggggagt ggaatgagaa gcttcctggg gatgggcaaa
     3841 ccagcctggc ccactgggac tgaagtatat ctccacacgg gttttagcac catcttcaga
     3901 tggaatgata ggcagatgga cagacaagct gatggacaga cagtactggg atgggccagc
     3961 ttgggctatt atccacagga acagcgagga tttcctgtgg gtttctctgc tccatcttct
     4021 cttgccttgc cctcacacct cctgacctcc atctctttct gcccccctcc ccccgctcgc
     4081 ctctcccact ggaccccatc tttctctttg gtgcacactc aatcattgtg atgaggaatg
     4141 gaagttcaag ggaactccct ctctgactct cctccgccag cctagaaagg attccatatg
     4201 ggggtgggag ggagacaagc gactcagctc agggagctac cagagaaaaa cagcaactgg
     4261 tgtgggtgct ttttttttta atttgaataa aaataattag aagtgatatc ctttgataag
     4321 atgccgtctc ccctttcctg ctctcagccc tttctgctcc ctgaagccgg ggatatggtg
     4381 acccccaggg tcgtaagtct aagaagatgg gcgggggagc gggctggggg ctggggcaga
     4441 cggaatgtca tctgcagata tcacccctag ggtaccaatg tttgtggtat taggtttgct
     4501 ttgttttgtt ttggtctttt gttgttttat taaagaaaag ctaaagaccg tgtgagccct
     4561 gctggtgggc tttccatgga tgtagcatat ggaagagagt ttttatattg catttttatg
     4621 gattatttta taatgtggga ctcagtctgg gaagaaagat gagggtgtct aaaacctgcc
     4681 catctccagt gctccaactg agcggctgcc ccgaacagga tgtatgttgg gacatggaaa
     4741 gaccgtggca ccccgcacct tcctgagagg catgtcgaca tgcctgtctg gagtctgtcc
     4801 atctgtctct gggtttcaga tgatcactgg ccaccacttg ttaaggctct agccagaagg
     4861 gagggttagg gtggaagaga gttattcctg aagaaaaaag aaaaattgaa acatcattgt
     4921 aatgaagctt tttatatttt taaaagttac tatttaaaaa
//
LOCUS       NM_001436413            4954 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 12, mRNA.
ACCESSION   NM_001436413 XM_063266234
VERSION     NM_001436413.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4954)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4954)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 4954)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 4954)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_063266234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.45730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000008.1  70753436-70753516
            82-924              JAXUCZ010000008.1  70753692-70754534
            925-1025            JAXUCZ010000008.1  70755028-70755128
            1026-1089           JAXUCZ010000008.1  70755588-70755651
            1090-1134           JAXUCZ010000008.1  70756612-70756656
            1135-1197           JAXUCZ010000008.1  70774229-70774291
            1198-1272           JAXUCZ010000008.1  70775659-70775733
            1273-1477           JAXUCZ010000008.1  70782797-70783001
            1478-1494           JAXUCZ010000008.1  70784419-70784435
            1495-1614           JAXUCZ010000008.1  70788295-70788414
            1615-1665           JAXUCZ010000008.1  70789262-70789312
            1666-1818           JAXUCZ010000008.1  70789717-70789869
            1819-1960           JAXUCZ010000008.1  70790230-70790371
            1961-2145           JAXUCZ010000008.1  70790810-70790994
            2146-2222           JAXUCZ010000008.1  70792121-70792197
            2223-2472           JAXUCZ010000008.1  70793078-70793327
            2473-2720           JAXUCZ010000008.1  70793690-70793937
            2721-2868           JAXUCZ010000008.1  70794731-70794878
            2869-3019           JAXUCZ010000008.1  70795421-70795571
            3020-3096           JAXUCZ010000008.1  70796240-70796316
            3097-4954           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..4954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4954
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..81
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            82..924
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    505..507
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             901..3204
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 11 is encoded by transcript variant 12;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 11"
                     /protein_id="NP_001423342.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGL
                     HNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSAD
                     GQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWD
                     ISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAE
                     LTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHD
                     GTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH
                     HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL
                     SCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    901..1293
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    952..1299
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    952..1299
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1288..1389
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1497
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1450..1947
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1498..1704
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1507..1509
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1519..1521
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1531..1533
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1549..1551
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1573..1584
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1594..1596
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1618..1620
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1633..1635
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1651..2301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1651..2301
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1675..1677
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1687..1689
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1699..1701
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1723..1725
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1756..1758
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1834..1836
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1849..1851
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1855..1857
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1861..1863
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1882..1884
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1900..1902
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2137..2139
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2335..2451
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2338..3195
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2338..3195
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2350..2469
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2350..2469
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2473..2592
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2491..2607
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2491..2607
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2605..2724
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2620..2730
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2620..2730
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2731..2850
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2749..2856
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2749..2856
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2854..2973
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    2869..2970
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2869..2970
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2977..3096
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    2992..3096
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2992..3096
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3100..3198
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3115..3189
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3115..3189
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            925..1025
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1089
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1134
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1197
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1272
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1494
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1614
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1665
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1818
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1960
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2145
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2222
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2472
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2720
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2868
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3019
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3096
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..4954
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca gcctgcgcgc tcctaggcag cagggacgcc gaccgctccc
      121 cgccggagac gcagccgatt cacttgagag caaagaagac cccttcgccg aggcttccta
      181 tgccggctgg agttaggatg ccacggccca ttatttgcac cgactaaccc ggagttcctc
      241 ctcggccctg ggaaggactg gcggcggcgg ctggagcaga cagagcagca ggctctcttc
      301 tccgagggga ggggggggcg tcgaagcgcc ctcgctgggc tctagccctc acccacggtc
      361 ctcaagccgt cacctcggtg gcctgcttcc tttttcttct ccccgcgact ccgggcccga
      421 ccgcctctgg gatttgaccc gcgcgccccg gatgctccga gctgcccaga cgcgcccccc
      481 cccctccagc ctcatcgtgc tgattgaccc gtgaggggac aagagaaacc caccccccaa
      541 cctccgggcc tcgggatcct gctctggagc tgccagggag ccgatgatgt ccacgcagac
      601 ccggcttctg acactgtcca cgcagccggg ggaaggtggc cggccgcagc cggccgagcc
      661 ttaggcgcac aaagcgcgag cccgccgacg actttgccgc tcgctccgcc gctctttgtc
      721 tgcacttggg gcgcacgccc gactctggga tttcgctgcg agagcgggct gggggggccg
      781 ggggcgagct ctcggttccc cggccgcccc ccgctcgggc tcgcctcccc cctcccccgc
      841 acgtccccgg ctcgggctct cagcgcttcc aagctctcgg aatcgcgacc cctccctgcc
      901 atgtatccgc aaggcagaca tccggcaccc catcaacccg ggcagccagg atttaaattc
      961 actgtggccg agtcctgtga caggatcaaa gacgaattcc agttcctgca agctcagtat
     1021 cacagcctca aagtggagta cgacaagctg gcgaacgaga agacagagat gcagcgccat
     1081 tatgtgatgt actatgagat gtcctacggc ttgaatatcg aaatgcacaa gcagacagag
     1141 atcgcgaaga gactgaacac gattctagcc cagatcatgc cttttttgtc acaggagcat
     1201 cagcagcaag tggcgcaggc tgtggaacgc gccaagcagg tcaccatgac ggagctgaac
     1261 gccatcatcg ggcagcagca actccaggca cagcacctct cccatgccac acatggtccc
     1321 ccggtccagc tgccacccca cccgtcaggc ctccaacctc ctgggattcc cccagtgaca
     1381 ggaagcagct ctgggttgct ggcacttggt gccctgggaa gccaagccca cttggcagtg
     1441 aaggatgaga agaaccatca tgaactggat cacagagaga gagagtccag cacgaacaat
     1501 tctgtgtcac cctcagaaag cctccgggcc agtgagaagc accggggctc tgcagactac
     1561 agcatggaag ccaagaagcg gaaagcggaa gagaaagaca gcctgagccg atacgacagc
     1621 gatggggaca agagtgatga cctggtagtg gatgtctcca atgaggaccc agcgacaccc
     1681 cgggtgagcc cagcacactc ccctcctgaa aatgggctgg acaaagcccg aggtctgaag
     1741 aaagacgccc ccaccagccc agcctctgtg gcttcctcca gcagcacgcc ttcctccaag
     1801 accaaagacc ttggtcataa tgacaaatct tccacacctg ggctcaagtc caacacacca
     1861 acgccaagga acgatgcccc aactccaggc accagcacca ccccggggct ccggtcaatg
     1921 ccgggcaaac ctccaggcat ggacccgata ggtataatgg cctcggccct gcgcacaccc
     1981 atctccctca ccagctccta tgcagcaccc tttgccatga tgagccacca cgagatgaat
     2041 ggctccctca ccagcccaag cgcctatgct ggcctacaca acatcccatc ccagatgagc
     2101 gccgccgcag cagctgcagc cgccgcctat ggccgatcgc caatggttgg ttttgaccct
     2161 catcccccga tgcgggccac aggcctgccc tccagtcttg cctccattcc tggagggaaa
     2221 ccggcgtact ccttccatgt gagtgccgac gggcagatgc aacctgtgcc cttcccccat
     2281 gatgcgctag caggccccgg cattcccagg catgcccggc agatcaacac actcagccat
     2341 ggggaggtgg tatgtgccgt gaccatcagc aaccccacga ggcacgtcta cacaggcggc
     2401 aagggctgtg tgaagatatg ggacatcagc cagccgggca gcaagagtcc catctcccag
     2461 ctggactgcc tgaacaggga caactacatc cgctcatgca agcttctccc tgatgggcgc
     2521 acgctcattg tgggtggtga ggccagcaca ctcaccatct gggacctggc ctcgcccacg
     2581 ccccgcatca aggctgagct gacgtcctcg gctccagcct gttacgccct ggccatcagt
     2641 cctgatgcca aagtctgttt ctcctgctgc agtgatggga acattgcagt ttgggatctg
     2701 cacaaccaga ccctggtcag gcagttccag ggccacacgg atggggccag ctgtatagac
     2761 atctctcatg atggcactaa actgtggacc gggggcctgg acaacactgt gcgctcctgg
     2821 gacctgcgtg aagggcggca gctacagcaa cacgacttca cctcccagat cttctccctg
     2881 ggttactgcc ccactgggga gtggctcgcc gtgggcatgg agagcagcaa cgtagaggtt
     2941 ctgcaccaca ccaagccgga caagtaccaa ctgcatctgc acgagagctg cgtgctgtcc
     3001 ctcaagtttg cctactgtgg caagtggttt gtgagcactg ggaaagacaa ccttctcaat
     3061 gcctggagga cgccttacgg agccagcatc ttccagtcta aagaatcctc gtccgtcttg
     3121 agctgtgata tttcagcgga tgacaaatat attgtaacgg gctctggtga caagaaggcc
     3181 acagtttacg aggtcatcta ctgaacaagg actctaagag gcctgtcaaa ctctgggaga
     3241 cacccacgcg gccctgacag ggagatgctg gccaggcccc gaggatggca gaagagtgag
     3301 ggacagcatt gtggggctgc cctccggaag gtggagagga cgcacgcccc tttgtggatt
     3361 gctgtgtctg acagacttga aggactttct cctctccccc tcaccagtgc tggcagatgc
     3421 ttcaattaga tttctctgga ggcttctgct ttcgtttccc acacagacac cctcatgagt
     3481 ctctgtctct tcctcccctg tctgatctgt cccctcccta ctccgggttg ggggcatgct
     3541 ggagtagaca ttgttgtttc tggggagggg cgcctcgttc tgattgtgca gtgcacaagg
     3601 tttgtgaaca atgtaaataa gagactgtgg ttgctgactg gccagtgagg gaggaggccc
     3661 cttcccacca gtgctcgccg tgtattttgc ctgctgtatt tgtaacccac tcgcggtggt
     3721 ggcttttctt tctttctttt cttaagattt tttttaaaca gatgttctgt ggggaaagta
     3781 ggcagagata gagagtcggg gagtggaatg agaagcttcc tggggatggg caaaccagcc
     3841 tggcccactg ggactgaagt atatctccac acgggtttta gcaccatctt cagatggaat
     3901 gataggcaga tggacagaca agctgatgga cagacagtac tgggatgggc cagcttgggc
     3961 tattatccac aggaacagcg aggatttcct gtgggtttct ctgctccatc ttctcttgcc
     4021 ttgccctcac acctcctgac ctccatctct ttctgccccc ctccccccgc tcgcctctcc
     4081 cactggaccc catctttctc tttggtgcac actcaatcat tgtgatgagg aatggaagtt
     4141 caagggaact ccctctctga ctctcctccg ccagcctaga aaggattcca tatgggggtg
     4201 ggagggagac aagcgactca gctcagggag ctaccagaga aaaacagcaa ctggtgtggg
     4261 tgcttttttt tttaatttga ataaaaataa ttagaagtga tatcctttga taagatgccg
     4321 tctccccttt cctgctctca gccctttctg ctccctgaag ccggggatat ggtgaccccc
     4381 agggtcgtaa gtctaagaag atgggcgggg gagcgggctg ggggctgggg cagacggaat
     4441 gtcatctgca gatatcaccc ctagggtacc aatgtttgtg gtattaggtt tgctttgttt
     4501 tgttttggtc ttttgttgtt ttattaaaga aaagctaaag accgtgtgag ccctgctggt
     4561 gggctttcca tggatgtagc atatggaaga gagtttttat attgcatttt tatggattat
     4621 tttataatgt gggactcagt ctgggaagaa agatgagggt gtctaaaacc tgcccatctc
     4681 cagtgctcca actgagcggc tgccccgaac aggatgtatg ttgggacatg gaaagaccgt
     4741 ggcaccccgc accttcctga gaggcatgtc gacatgcctg tctggagtct gtccatctgt
     4801 ctctgggttt cagatgatca ctggccacca cttgttaagg ctctagccag aagggagggt
     4861 tagggtggaa gagagttatt cctgaagaaa aaagaaaaat tgaaacatca ttgtaatgaa
     4921 gctttttata tttttaaaag ttactattta aaaa
//
LOCUS       NM_012801               2265 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus platelet derived growth factor subunit A (Pdgfa),
            transcript variant 3, mRNA.
ACCESSION   NM_012801
VERSION     NM_012801.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Rashid,F.N., Clayton,Z.E., Ogawa,M., Perdomo,J., Hume,R.D.,
            Kizana,E. and Chong,J.J.H.
  TITLE     Platelet derived growth factor-A (Pdgf-a) gene transfer modulates
            scar composition and improves left ventricular function after
            myocardial infarction
  JOURNAL   Int J Cardiol 341, 24-30 (2021)
   PUBMED   34265313
  REMARK    GeneRIF: Platelet derived growth factor-A (Pdgf-a) gene transfer
            modulates scar composition and improves left ventricular function
            after myocardial infarction.
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Connolly,N.P., Stokum,J.A., Schneider,C.S., Ozawa,T., Xu,S.,
            Galisteo,R., Castellani,R.J., Kim,A.J., Simard,J.M., Winkles,J.A.,
            Holland,E.C. and Woodworth,G.F.
  TITLE     Genetically engineered rat gliomas: PDGF-driven tumor initiation
            and progression in tv-a transgenic rats recreate key features of
            human brain cancer
  JOURNAL   PLoS One 12 (3), e0174557 (2017)
   PUBMED   28358926
  REMARK    GeneRIF: an Ntv-a transgenic rat colony was established and used to
            study glial brain tumors driven by two well-characterized oncogenic
            gene transformations, PDGFA overexpression and p53 depletion.
            Combined PDGFA and p53 alterations resulted in large, heterogeneous
            tumors in all affected animals
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Shepherd,J.A., Stamper,E., Matheson,P.J., Galganski,L.,
            Garrison,R.N., Madden,K. and Downard,C.D.
  TITLE     Alterations in platelet-derived growth factor expression in the
            pathophysiology of necrotizing enterocolitis
  JOURNAL   J Surg Res 198 (2), 377-383 (2015)
   PUBMED   25899145
  REMARK    GeneRIF: expression altered in experimental Necrotizing
            enterocolitis
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Ha,J.M., Yun,S.J., Kim,Y.W., Jin,S.Y., Lee,H.S., Song,S.H.,
            Shin,H.K. and Bae,S.S.
  TITLE     Platelet-derived growth factor regulates vascular smooth muscle
            phenotype via mammalian target of rapamycin complex 1
  JOURNAL   Biochem Biophys Res Commun 464 (1), 57-62 (2015)
   PUBMED   26032503
  REMARK    GeneRIF: PDGF regulates vascular smooth muscle phenotype via
            mammalian target of rapamycin complex 1.
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Bryckaert,M.C., Rendu,F., Tobelem,G. and Wasteson,A.
  TITLE     Collagen-induced binding to human platelets of platelet-derived
            growth factor leading to inhibition of P43 and P20 phosphorylation
  JOURNAL   J Biol Chem 264 (8), 4336-4341 (1989)
   PUBMED   2538439
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Escobedo,J.A., Navankasatussas,S., Cousens,L.S., Coughlin,S.R.,
            Bell,G.I. and Williams,L.T.
  TITLE     A common PDGF receptor is activated by homodimeric A and B forms of
            PDGF
  JOURNAL   Science 240 (4858), 1532-1534 (1988)
   PUBMED   2836953
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Womer,R.B., Frick,K., Mitchell,C.D., Ross,A.H., Bishayee,S. and
            Scher,C.D.
  TITLE     PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma
            cells but does not stimulate cell replication
  JOURNAL   J Cell Physiol 132 (1), 65-72 (1987)
   PUBMED   2439522
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Heldin,C.H., Westermark,B. and Wasteson,A.
  TITLE     Platelet-derived growth factor: purification and partial
            characterization
  JOURNAL   Proc Natl Acad Sci U S A 76 (8), 3722-3726 (1979)
   PUBMED   291037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 11, 2025 this sequence version replaced NM_012801.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06238.1, SRR22582419.1725151.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000012.1  20759366-20759582
            218-415             JAXUCZ010000012.1  20760368-20760565
            416-545             JAXUCZ010000012.1  20761914-20762043
            546-642             JAXUCZ010000012.1  20763365-20763461
            643-747             JAXUCZ010000012.1  20768458-20768562
            748-935             JAXUCZ010000012.1  20770718-20770905
            936-1062            JAXUCZ010000012.1  20777995-20778121
            1063-2265           JAXUCZ010000012.1  20780032-20781234
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2265
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="platelet derived growth factor subunit A"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
     exon            1..217
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="upstream in-frame stop codon"
     exon            218..415
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            416..545
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1073
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; PDGF subunit A; Platelet-derived growth factor
                     A chain; platelet derived growth factor, alpha;
                     platelet-derived growth factor alpha polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit A isoform
                     2 precursor"
                     /protein_id="NP_036933.2"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
                     /translation="MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDL
                     QRLLEIDSVGAEDALETNLRAHGSHTVKHVPEKRPVPIRRKRSIEEAIPAVCKTRTVI
                     YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
                     KPKLKEVQVRLEEHLECACATSNLNPDHREEETDVR"
     sig_peptide     483..542
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    543..767
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     misc_feature    543..767
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     misc_feature    762..1025
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    762..1025
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(762..773,879..881,885..896,939..950)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(762..773,879..881,885..896,939..950)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(768..770,867..869,879..881,900..902,1011..1013,
                     1017..1019)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(768..770,867..869,879..881,900..902,1011..1013,
                     1017..1019)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(849..851,876..878)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(849..851,876..878)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    882..884
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P28576.2); glycosylation site"
     misc_feature    954..968
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="propagated from UniProtKB/Swiss-Prot (P28576.2);
                     Region: Receptor binding site. /evidence=ECO:0000255"
     exon            546..642
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            643..747
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            748..935
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1062
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2265
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccgcaaa gaggtgtcct ctggtcctct ctgcttctga gaagggcttg gcaggacagg
       61 acgcgtagaa caatcgggat aaaacggtga ggaactcgac tcaggtccag cgtggtcctg
      121 gtagtcgccg ccagaagcca tccggtgaat ctccctctgc agagcagcac aaagtttcac
      181 cagaacggac aaggcctggg ctttctaaga cctcgagcaa cccgttcagg gtgcggctgg
      241 gccttctgcc aggggctaag gatctggagg gtgcagggtg tcaaggtggc gatgaggcag
      301 gtggcagcct cctccctgac tctagcctcg cttccacctc cacacaagag tgcaagttcc
      361 tcaatcaggt gtcccaggct ttggctctgg ggcgcgggcg cgtggcagcc gtcaggagcc
      421 cggctggagc gcccgccccg cggcctcgcc tccctgccga gcttccagcg cctcgggacg
      481 cgatgaggac ctgggcttgc ctgctgctcc tcggctgcgg atacctcgcc catgccctgg
      541 ccgaggaagc cgagataccc cgggagttga tcgagcgact ggctcgaagt cagatccaca
      601 gcatccggga cctccagcga ctcttggaga tagactccgt aggggctgag gatgccttgg
      661 agacaaacct gagagcccat gggtcccaca ctgttaagca tgtgccggag aagcggcctg
      721 tgcccatccg caggaagaga agtattgagg aagccattcc cgcagtttgc aagaccagga
      781 cggtcattta cgagatacct cggagccagg tggaccccac atcggccaac ttcttgatct
      841 ggcccccatg tgtggaggtg aagcgctgca ctggctgctg taacaccagc agcgtcaagt
      901 gccagccctc aagggtccac caccgcagtg tcaaggtggc caaagtggag tatgtcagga
      961 agaagccaaa attgaaagag gtccaggtga ggttagagga gcacctggag tgcgcatgcg
     1021 cgacctccaa cctgaaccca gaccatcggg aggaggagac ggatgtgagg tgagatgagc
     1081 tggctgccct ctcccgggac acggatgtac gtggcgtgtg acattcctga acatactatg
     1141 tatggtgctt cattgccaat gtgcgtgcag tctttgttct cctccgtgaa aaactgtgtc
     1201 cgaggacaaa gagacagtgt ccgtttgttc agtgtgacat caaagcaagt actgtagcac
     1261 tcggagagac agtgagaaag cttccttgtc acagagagcg aaaacaaaac cacaaaaaag
     1321 aaaaaaaaaa aaaacaaaaa aattaaaaaa gaaaaaaaaa aaacaaaacc acacccaaca
     1381 acaaaaaaac cccaccagaa gaaacaaaaa aagactgaag cgggcaacag aagggccgcc
     1441 ctgcaggact gaccctcgag tggtggctga tgttggccac caccctggat tctgcccgtg
     1501 ggcacaggtg cttttcgcca aggacgccca gaatgctacc tgccagctct actaggtaca
     1561 ggaactgaac gaatgggaga agcccgcggg cctggaagcc accgcctgga ctgagtctgc
     1621 ctgggaactt cctgatggcc ttacgtggaa tttctttttt cttatctttt tctttttttt
     1681 tttttccttt ccttttattt ttttacacca tgaagtaatt gagcttctcc tttttattct
     1741 ctgcctagcc tttttttttt ttttttttta aatctcttgg atgacatttt cgttgataac
     1801 atgcacgagg ctgctgtaag ttgggacagt gagacggtta tttttttttt cctagccaaa
     1861 ctaatgaggt gtattaaaat aaatacctac ctatacatca tttccgatgc gcctctgcct
     1921 tcctttaaca tcttctagct taggtcattt gagagaacta tgagaatcgc tcagttttgg
     1981 gtctccctcc acccctaggg accaccctcc attgctaaac ggcttctgcg gcagtgtgga
     2041 aactcgacta agattatttt atagtaagct gttgggtttc actgttaacc agaactgtgt
     2101 gtgtgtgtgt gtggtttcct tgttttggtt tggttttgta aaggtgaact ttgtattttt
     2161 aatattatca gtttatatac ctgagagcct gctatatata tatttttttt attttgaact
     2221 aaaaggagaa aaaaaaatca acgaacttaa tgcacatcag atgca
//
LOCUS       NM_001436404            5174 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 3, mRNA.
ACCESSION   NM_001436404 XM_008766347
VERSION     NM_001436404.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5174)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5174)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5174)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5174)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_008766347.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.32010.1,
                                           SRR26643292.33958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1682           JAXUCZ010000008.1  70782797-70783001
            1683-1699           JAXUCZ010000008.1  70784419-70784435
            1700-1819           JAXUCZ010000008.1  70788295-70788414
            1820-1870           JAXUCZ010000008.1  70789262-70789312
            1871-2023           JAXUCZ010000008.1  70789717-70789869
            2024-2165           JAXUCZ010000008.1  70790230-70790371
            2166-2365           JAXUCZ010000008.1  70790810-70791009
            2366-2442           JAXUCZ010000008.1  70792121-70792197
            2443-2692           JAXUCZ010000008.1  70793078-70793327
            2693-2940           JAXUCZ010000008.1  70793690-70793937
            2941-3088           JAXUCZ010000008.1  70794731-70794878
            3089-3239           JAXUCZ010000008.1  70795421-70795571
            3240-3316           JAXUCZ010000008.1  70796240-70796316
            3317-5174           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5174
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3424
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 3"
                     /protein_id="NP_001423333.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG
                     LQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESL
                     RASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAH
                     SPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRN
                     DAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGS
                     LTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLAS
                     IPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPT
                     RHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTL
                     TIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQF
                     QGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGE
                     WLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTP
                     YGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    <1856..2521
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1856..2521
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <2558..3415
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2558..3415
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2570..2689
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2570..2689
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2711..2827
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2711..2827
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2840..2950
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2840..2950
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2969..3076
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2969..3076
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3089..3190
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3089..3190
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3212..3316
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3212..3316
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3335..3409
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3335..3409
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1819
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1870
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2023
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2165
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2365
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2442
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2692
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2940
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3088
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3239
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3316
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..5174
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag cagcaactcc aggcacagca
     1501 cctctcccat gccacacatg gtcccccggt ccagctgcca ccccacccgt caggcctcca
     1561 acctcctggg attcccccag tgacaggaag cagctctggg ttgctggcac ttggtgccct
     1621 gggaagccaa gcccacttgg cagtgaagga tgagaagaac catcatgaac tggatcacag
     1681 agagagagag tccagcacga acaattctgt gtcaccctca gaaagcctcc gggccagtga
     1741 gaagcaccgg ggctctgcag actacagcat ggaagccaag aagcggaaag cggaagagaa
     1801 agacagcctg agccgatacg acagcgatgg ggacaagagt gatgacctgg tagtggatgt
     1861 ctccaatgag gacccagcga caccccgggt gagcccagca cactcccctc ctgaaaatgg
     1921 gctggacaaa gcccgaggtc tgaagaaaga cgcccccacc agcccagcct ctgtggcttc
     1981 ctccagcagc acgccttcct ccaagaccaa agaccttggt cataatgaca aatcttccac
     2041 acctgggctc aagtccaaca caccaacgcc aaggaacgat gccccaactc caggcaccag
     2101 caccaccccg gggctccggt caatgccggg caaacctcca ggcatggacc cgataggtat
     2161 aatggcctcg gccctgcgca cacccatctc cctcaccagc tcctatgcag caccctttgc
     2221 catgatgagc caccacgaga tgaatggctc cctcaccagc ccaagcgcct atgctggcct
     2281 acacaacatc ccatcccaga tgagcgccgc cgcagcagct gcagccgccg cctatggccg
     2341 atcgccaatg gtgagctttg gagctgttgg ttttgaccct catcccccga tgcgggccac
     2401 aggcctgccc tccagtcttg cctccattcc tggagggaaa ccggcgtact ccttccatgt
     2461 gagtgccgac gggcagatgc aacctgtgcc cttcccccat gatgcgctag caggccccgg
     2521 cattcccagg catgcccggc agatcaacac actcagccat ggggaggtgg tatgtgccgt
     2581 gaccatcagc aaccccacga ggcacgtcta cacaggcggc aagggctgtg tgaagatatg
     2641 ggacatcagc cagccgggca gcaagagtcc catctcccag ctggactgcc tgaacaggga
     2701 caactacatc cgctcatgca agcttctccc tgatgggcgc acgctcattg tgggtggtga
     2761 ggccagcaca ctcaccatct gggacctggc ctcgcccacg ccccgcatca aggctgagct
     2821 gacgtcctcg gctccagcct gttacgccct ggccatcagt cctgatgcca aagtctgttt
     2881 ctcctgctgc agtgatggga acattgcagt ttgggatctg cacaaccaga ccctggtcag
     2941 gcagttccag ggccacacgg atggggccag ctgtatagac atctctcatg atggcactaa
     3001 actgtggacc gggggcctgg acaacactgt gcgctcctgg gacctgcgtg aagggcggca
     3061 gctacagcaa cacgacttca cctcccagat cttctccctg ggttactgcc ccactgggga
     3121 gtggctcgcc gtgggcatgg agagcagcaa cgtagaggtt ctgcaccaca ccaagccgga
     3181 caagtaccaa ctgcatctgc acgagagctg cgtgctgtcc ctcaagtttg cctactgtgg
     3241 caagtggttt gtgagcactg ggaaagacaa ccttctcaat gcctggagga cgccttacgg
     3301 agccagcatc ttccagtcta aagaatcctc gtccgtcttg agctgtgata tttcagcgga
     3361 tgacaaatat attgtaacgg gctctggtga caagaaggcc acagtttacg aggtcatcta
     3421 ctgaacaagg actctaagag gcctgtcaaa ctctgggaga cacccacgcg gccctgacag
     3481 ggagatgctg gccaggcccc gaggatggca gaagagtgag ggacagcatt gtggggctgc
     3541 cctccggaag gtggagagga cgcacgcccc tttgtggatt gctgtgtctg acagacttga
     3601 aggactttct cctctccccc tcaccagtgc tggcagatgc ttcaattaga tttctctgga
     3661 ggcttctgct ttcgtttccc acacagacac cctcatgagt ctctgtctct tcctcccctg
     3721 tctgatctgt cccctcccta ctccgggttg ggggcatgct ggagtagaca ttgttgtttc
     3781 tggggagggg cgcctcgttc tgattgtgca gtgcacaagg tttgtgaaca atgtaaataa
     3841 gagactgtgg ttgctgactg gccagtgagg gaggaggccc cttcccacca gtgctcgccg
     3901 tgtattttgc ctgctgtatt tgtaacccac tcgcggtggt ggcttttctt tctttctttt
     3961 cttaagattt tttttaaaca gatgttctgt ggggaaagta ggcagagata gagagtcggg
     4021 gagtggaatg agaagcttcc tggggatggg caaaccagcc tggcccactg ggactgaagt
     4081 atatctccac acgggtttta gcaccatctt cagatggaat gataggcaga tggacagaca
     4141 agctgatgga cagacagtac tgggatgggc cagcttgggc tattatccac aggaacagcg
     4201 aggatttcct gtgggtttct ctgctccatc ttctcttgcc ttgccctcac acctcctgac
     4261 ctccatctct ttctgccccc ctccccccgc tcgcctctcc cactggaccc catctttctc
     4321 tttggtgcac actcaatcat tgtgatgagg aatggaagtt caagggaact ccctctctga
     4381 ctctcctccg ccagcctaga aaggattcca tatgggggtg ggagggagac aagcgactca
     4441 gctcagggag ctaccagaga aaaacagcaa ctggtgtggg tgcttttttt tttaatttga
     4501 ataaaaataa ttagaagtga tatcctttga taagatgccg tctccccttt cctgctctca
     4561 gccctttctg ctccctgaag ccggggatat ggtgaccccc agggtcgtaa gtctaagaag
     4621 atgggcgggg gagcgggctg ggggctgggg cagacggaat gtcatctgca gatatcaccc
     4681 ctagggtacc aatgtttgtg gtattaggtt tgctttgttt tgttttggtc ttttgttgtt
     4741 ttattaaaga aaagctaaag accgtgtgag ccctgctggt gggctttcca tggatgtagc
     4801 atatggaaga gagtttttat attgcatttt tatggattat tttataatgt gggactcagt
     4861 ctgggaagaa agatgagggt gtctaaaacc tgcccatctc cagtgctcca actgagcggc
     4921 tgccccgaac aggatgtatg ttgggacatg gaaagaccgt ggcaccccgc accttcctga
     4981 gaggcatgtc gacatgcctg tctggagtct gtccatctgt ctctgggttt cagatgatca
     5041 ctggccacca cttgttaagg ctctagccag aagggagggt tagggtggaa gagagttatt
     5101 cctgaagaaa aaagaaaaat tgaaacatca ttgtaatgaa gctttttata tttttaaaag
     5161 ttactattta aaaa
//
LOCUS       NM_001436409            5147 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 8, mRNA.
ACCESSION   NM_001436409 XM_063266231
VERSION     NM_001436409.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5147)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5147)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5147)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5147)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_063266231.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.32012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1679           JAXUCZ010000008.1  70782800-70783001
            1680-1696           JAXUCZ010000008.1  70784419-70784435
            1697-1816           JAXUCZ010000008.1  70788295-70788414
            1817-1867           JAXUCZ010000008.1  70789262-70789312
            1868-2020           JAXUCZ010000008.1  70789717-70789869
            2021-2153           JAXUCZ010000008.1  70790230-70790362
            2154-2338           JAXUCZ010000008.1  70790810-70790994
            2339-2415           JAXUCZ010000008.1  70792121-70792197
            2416-2665           JAXUCZ010000008.1  70793078-70793327
            2666-2913           JAXUCZ010000008.1  70793690-70793937
            2914-3061           JAXUCZ010000008.1  70794731-70794878
            3062-3212           JAXUCZ010000008.1  70795421-70795571
            3213-3289           JAXUCZ010000008.1  70796240-70796316
            3290-5147           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5147
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5147
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3397
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 8 is encoded by transcript variant 8;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 8"
                     /protein_id="NP_001423338.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQLQAQHLSHATHGPPVQLPPHPSGL
                     QPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLR
                     ASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHS
                     PPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRND
                     APTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSP
                     SAYAGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYS
                     FHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKG
                     CVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPT
                     PRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC
                     IDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESS
                     NVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK
                     ESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1501
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1501
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1490..1591
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1496..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1652..2149
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1700..1906
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1709..1711
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1721..1723
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1733..1735
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1751..1753
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1775..1786
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1796..1798
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1820..1822
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1835..1837
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1853..2494
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1853..2494
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1877..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1889..1891
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1901..1903
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1907..2434
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: SP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1925..1927
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1958..1960
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2051..2053
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2063..2065
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2084..2086
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2102..2104
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2330..2332
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2528..2644
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2531..3388
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2531..3388
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2543..2662
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2543..2662
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2666..2785
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2684..2800
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2684..2800
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2798..2917
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2813..2923
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2813..2923
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2924..3043
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2942..3049
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2942..3049
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3047..3166
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3062..3163
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3062..3163
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3170..3289
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3185..3289
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3185..3289
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3293..3391
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3308..3382
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3308..3382
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1679
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1816
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1867
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2020
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2153
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2338
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2415
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2665
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2913
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3061
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3212
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3289
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..5147
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag caactccagg cacagcacct
     1501 ctcccatgcc acacatggtc ccccggtcca gctgccaccc cacccgtcag gcctccaacc
     1561 tcctgggatt cccccagtga caggaagcag ctctgggttg ctggcacttg gtgccctggg
     1621 aagccaagcc cacttggcag tgaaggatga gaagaaccat catgaactgg atcacagaga
     1681 gagagagtcc agcacgaaca attctgtgtc accctcagaa agcctccggg ccagtgagaa
     1741 gcaccggggc tctgcagact acagcatgga agccaagaag cggaaagcgg aagagaaaga
     1801 cagcctgagc cgatacgaca gcgatgggga caagagtgat gacctggtag tggatgtctc
     1861 caatgaggac ccagcgacac cccgggtgag cccagcacac tcccctcctg aaaatgggct
     1921 ggacaaagcc cgaggtctga agaaagacgc ccccaccagc ccagcctctg tggcttcctc
     1981 cagcagcacg ccttcctcca agaccaaaga ccttggtcat aatgacaaat cttccacacc
     2041 tgggctcaag tccaacacac caacgccaag gaacgatgcc ccaactccag gcaccagcac
     2101 caccccgggg ctccggtcaa tgccgggcaa acctccaggc atggacccga tagcctcggc
     2161 cctgcgcaca cccatctccc tcaccagctc ctatgcagca ccctttgcca tgatgagcca
     2221 ccacgagatg aatggctccc tcaccagccc aagcgcctat gctggcctac acaacatccc
     2281 atcccagatg agcgccgccg cagcagctgc agccgccgcc tatggccgat cgccaatggt
     2341 tggttttgac cctcatcccc cgatgcgggc cacaggcctg ccctccagtc ttgcctccat
     2401 tcctggaggg aaaccggcgt actccttcca tgtgagtgcc gacgggcaga tgcaacctgt
     2461 gcccttcccc catgatgcgc tagcaggccc cggcattccc aggcatgccc ggcagatcaa
     2521 cacactcagc catggggagg tggtatgtgc cgtgaccatc agcaacccca cgaggcacgt
     2581 ctacacaggc ggcaagggct gtgtgaagat atgggacatc agccagccgg gcagcaagag
     2641 tcccatctcc cagctggact gcctgaacag ggacaactac atccgctcat gcaagcttct
     2701 ccctgatggg cgcacgctca ttgtgggtgg tgaggccagc acactcacca tctgggacct
     2761 ggcctcgccc acgccccgca tcaaggctga gctgacgtcc tcggctccag cctgttacgc
     2821 cctggccatc agtcctgatg ccaaagtctg tttctcctgc tgcagtgatg ggaacattgc
     2881 agtttgggat ctgcacaacc agaccctggt caggcagttc cagggccaca cggatggggc
     2941 cagctgtata gacatctctc atgatggcac taaactgtgg accgggggcc tggacaacac
     3001 tgtgcgctcc tgggacctgc gtgaagggcg gcagctacag caacacgact tcacctccca
     3061 gatcttctcc ctgggttact gccccactgg ggagtggctc gccgtgggca tggagagcag
     3121 caacgtagag gttctgcacc acaccaagcc ggacaagtac caactgcatc tgcacgagag
     3181 ctgcgtgctg tccctcaagt ttgcctactg tggcaagtgg tttgtgagca ctgggaaaga
     3241 caaccttctc aatgcctgga ggacgcctta cggagccagc atcttccagt ctaaagaatc
     3301 ctcgtccgtc ttgagctgtg atatttcagc ggatgacaaa tatattgtaa cgggctctgg
     3361 tgacaagaag gccacagttt acgaggtcat ctactgaaca aggactctaa gaggcctgtc
     3421 aaactctggg agacacccac gcggccctga cagggagatg ctggccaggc cccgaggatg
     3481 gcagaagagt gagggacagc attgtggggc tgccctccgg aaggtggaga ggacgcacgc
     3541 ccctttgtgg attgctgtgt ctgacagact tgaaggactt tctcctctcc ccctcaccag
     3601 tgctggcaga tgcttcaatt agatttctct ggaggcttct gctttcgttt cccacacaga
     3661 caccctcatg agtctctgtc tcttcctccc ctgtctgatc tgtcccctcc ctactccggg
     3721 ttgggggcat gctggagtag acattgttgt ttctggggag gggcgcctcg ttctgattgt
     3781 gcagtgcaca aggtttgtga acaatgtaaa taagagactg tggttgctga ctggccagtg
     3841 agggaggagg ccccttccca ccagtgctcg ccgtgtattt tgcctgctgt atttgtaacc
     3901 cactcgcggt ggtggctttt ctttctttct tttcttaaga ttttttttaa acagatgttc
     3961 tgtggggaaa gtaggcagag atagagagtc ggggagtgga atgagaagct tcctggggat
     4021 gggcaaacca gcctggccca ctgggactga agtatatctc cacacgggtt ttagcaccat
     4081 cttcagatgg aatgataggc agatggacag acaagctgat ggacagacag tactgggatg
     4141 ggccagcttg ggctattatc cacaggaaca gcgaggattt cctgtgggtt tctctgctcc
     4201 atcttctctt gccttgccct cacacctcct gacctccatc tctttctgcc cccctccccc
     4261 cgctcgcctc tcccactgga ccccatcttt ctctttggtg cacactcaat cattgtgatg
     4321 aggaatggaa gttcaaggga actccctctc tgactctcct ccgccagcct agaaaggatt
     4381 ccatatgggg gtgggaggga gacaagcgac tcagctcagg gagctaccag agaaaaacag
     4441 caactggtgt gggtgctttt ttttttaatt tgaataaaaa taattagaag tgatatcctt
     4501 tgataagatg ccgtctcccc tttcctgctc tcagcccttt ctgctccctg aagccgggga
     4561 tatggtgacc cccagggtcg taagtctaag aagatgggcg ggggagcggg ctgggggctg
     4621 gggcagacgg aatgtcatct gcagatatca cccctagggt accaatgttt gtggtattag
     4681 gtttgctttg ttttgttttg gtcttttgtt gttttattaa agaaaagcta aagaccgtgt
     4741 gagccctgct ggtgggcttt ccatggatgt agcatatgga agagagtttt tatattgcat
     4801 ttttatggat tattttataa tgtgggactc agtctgggaa gaaagatgag ggtgtctaaa
     4861 acctgcccat ctccagtgct ccaactgagc ggctgccccg aacaggatgt atgttgggac
     4921 atggaaagac cgtggcaccc cgcaccttcc tgagaggcat gtcgacatgc ctgtctggag
     4981 tctgtccatc tgtctctggg tttcagatga tcactggcca ccacttgtta aggctctagc
     5041 cagaagggag ggttagggtg gaagagagtt attcctgaag aaaaaagaaa aattgaaaca
     5101 tcattgtaat gaagcttttt atatttttaa aagttactat ttaaaaa
//
LOCUS       NM_001436410            5144 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 9, mRNA.
ACCESSION   NM_001436410 XM_006243216
VERSION     NM_001436410.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5144)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5144)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5144)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5144)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243216.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28644.1,
                                           SRR26643285.31485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1447           JAXUCZ010000008.1  70775659-70775733
            1448-1652           JAXUCZ010000008.1  70782797-70783001
            1653-1669           JAXUCZ010000008.1  70784419-70784435
            1670-1789           JAXUCZ010000008.1  70788295-70788414
            1790-1840           JAXUCZ010000008.1  70789262-70789312
            1841-1993           JAXUCZ010000008.1  70789717-70789869
            1994-2135           JAXUCZ010000008.1  70790230-70790371
            2136-2335           JAXUCZ010000008.1  70790810-70791009
            2336-2412           JAXUCZ010000008.1  70792121-70792197
            2413-2662           JAXUCZ010000008.1  70793078-70793327
            2663-2910           JAXUCZ010000008.1  70793690-70793937
            2911-3058           JAXUCZ010000008.1  70794731-70794878
            3059-3209           JAXUCZ010000008.1  70795421-70795571
            3210-3286           JAXUCZ010000008.1  70796240-70796316
            3287-5144           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5144
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3394
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 9 is encoded by transcript variant 9;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 9"
                     /protein_id="NP_001423339.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIGIMASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGL
                     HNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSF
                     HVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGC
                     VKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTP
                     RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI
                     DISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSN
                     VEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKE
                     SSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1076..1468
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1463..1564
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1469..1672
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1625..2122
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1673..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1682..1684
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1694..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1706..1708
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1748..1759
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1769..1771
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1793..1795
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1808..1810
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1826..2491
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1826..2491
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1850..1852
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1862..1864
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1874..1876
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1898..1900
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1931..1933
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2009..2011
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2024..2026
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2030..2032
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2075..2077
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2312..2314
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2525..2641
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2528..3385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2528..3385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2540..2659
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2540..2659
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2663..2782
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2681..2797
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2681..2797
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2795..2914
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2810..2920
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2810..2920
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2921..3040
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2939..3046
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2939..3046
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3044..3163
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3059..3160
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3059..3160
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3167..3286
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3182..3286
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3182..3286
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3290..3388
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3305..3379
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3305..3379
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1447
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1652
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1669
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1993
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2135
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2335
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2412
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2662
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2910
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3058
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3209
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3286
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..5144
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcgggcag cagcaactcc aggcacagca cctctcccat gccacacatg gtcccccggt
     1501 ccagctgcca ccccacccgt caggcctcca acctcctggg attcccccag tgacaggaag
     1561 cagctctggg ttgctggcac ttggtgccct gggaagccaa gcccacttgg cagtgaagga
     1621 tgagaagaac catcatgaac tggatcacag agagagagag tccagcacga acaattctgt
     1681 gtcaccctca gaaagcctcc gggccagtga gaagcaccgg ggctctgcag actacagcat
     1741 ggaagccaag aagcggaaag cggaagagaa agacagcctg agccgatacg acagcgatgg
     1801 ggacaagagt gatgacctgg tagtggatgt ctccaatgag gacccagcga caccccgggt
     1861 gagcccagca cactcccctc ctgaaaatgg gctggacaaa gcccgaggtc tgaagaaaga
     1921 cgcccccacc agcccagcct ctgtggcttc ctccagcagc acgccttcct ccaagaccaa
     1981 agaccttggt cataatgaca aatcttccac acctgggctc aagtccaaca caccaacgcc
     2041 aaggaacgat gccccaactc caggcaccag caccaccccg gggctccggt caatgccggg
     2101 caaacctcca ggcatggacc cgataggtat aatggcctcg gccctgcgca cacccatctc
     2161 cctcaccagc tcctatgcag caccctttgc catgatgagc caccacgaga tgaatggctc
     2221 cctcaccagc ccaagcgcct atgctggcct acacaacatc ccatcccaga tgagcgccgc
     2281 cgcagcagct gcagccgccg cctatggccg atcgccaatg gtgagctttg gagctgttgg
     2341 ttttgaccct catcccccga tgcgggccac aggcctgccc tccagtcttg cctccattcc
     2401 tggagggaaa ccggcgtact ccttccatgt gagtgccgac gggcagatgc aacctgtgcc
     2461 cttcccccat gatgcgctag caggccccgg cattcccagg catgcccggc agatcaacac
     2521 actcagccat ggggaggtgg tatgtgccgt gaccatcagc aaccccacga ggcacgtcta
     2581 cacaggcggc aagggctgtg tgaagatatg ggacatcagc cagccgggca gcaagagtcc
     2641 catctcccag ctggactgcc tgaacaggga caactacatc cgctcatgca agcttctccc
     2701 tgatgggcgc acgctcattg tgggtggtga ggccagcaca ctcaccatct gggacctggc
     2761 ctcgcccacg ccccgcatca aggctgagct gacgtcctcg gctccagcct gttacgccct
     2821 ggccatcagt cctgatgcca aagtctgttt ctcctgctgc agtgatggga acattgcagt
     2881 ttgggatctg cacaaccaga ccctggtcag gcagttccag ggccacacgg atggggccag
     2941 ctgtatagac atctctcatg atggcactaa actgtggacc gggggcctgg acaacactgt
     3001 gcgctcctgg gacctgcgtg aagggcggca gctacagcaa cacgacttca cctcccagat
     3061 cttctccctg ggttactgcc ccactgggga gtggctcgcc gtgggcatgg agagcagcaa
     3121 cgtagaggtt ctgcaccaca ccaagccgga caagtaccaa ctgcatctgc acgagagctg
     3181 cgtgctgtcc ctcaagtttg cctactgtgg caagtggttt gtgagcactg ggaaagacaa
     3241 ccttctcaat gcctggagga cgccttacgg agccagcatc ttccagtcta aagaatcctc
     3301 gtccgtcttg agctgtgata tttcagcgga tgacaaatat attgtaacgg gctctggtga
     3361 caagaaggcc acagtttacg aggtcatcta ctgaacaagg actctaagag gcctgtcaaa
     3421 ctctgggaga cacccacgcg gccctgacag ggagatgctg gccaggcccc gaggatggca
     3481 gaagagtgag ggacagcatt gtggggctgc cctccggaag gtggagagga cgcacgcccc
     3541 tttgtggatt gctgtgtctg acagacttga aggactttct cctctccccc tcaccagtgc
     3601 tggcagatgc ttcaattaga tttctctgga ggcttctgct ttcgtttccc acacagacac
     3661 cctcatgagt ctctgtctct tcctcccctg tctgatctgt cccctcccta ctccgggttg
     3721 ggggcatgct ggagtagaca ttgttgtttc tggggagggg cgcctcgttc tgattgtgca
     3781 gtgcacaagg tttgtgaaca atgtaaataa gagactgtgg ttgctgactg gccagtgagg
     3841 gaggaggccc cttcccacca gtgctcgccg tgtattttgc ctgctgtatt tgtaacccac
     3901 tcgcggtggt ggcttttctt tctttctttt cttaagattt tttttaaaca gatgttctgt
     3961 ggggaaagta ggcagagata gagagtcggg gagtggaatg agaagcttcc tggggatggg
     4021 caaaccagcc tggcccactg ggactgaagt atatctccac acgggtttta gcaccatctt
     4081 cagatggaat gataggcaga tggacagaca agctgatgga cagacagtac tgggatgggc
     4141 cagcttgggc tattatccac aggaacagcg aggatttcct gtgggtttct ctgctccatc
     4201 ttctcttgcc ttgccctcac acctcctgac ctccatctct ttctgccccc ctccccccgc
     4261 tcgcctctcc cactggaccc catctttctc tttggtgcac actcaatcat tgtgatgagg
     4321 aatggaagtt caagggaact ccctctctga ctctcctccg ccagcctaga aaggattcca
     4381 tatgggggtg ggagggagac aagcgactca gctcagggag ctaccagaga aaaacagcaa
     4441 ctggtgtggg tgcttttttt tttaatttga ataaaaataa ttagaagtga tatcctttga
     4501 taagatgccg tctccccttt cctgctctca gccctttctg ctccctgaag ccggggatat
     4561 ggtgaccccc agggtcgtaa gtctaagaag atgggcgggg gagcgggctg ggggctgggg
     4621 cagacggaat gtcatctgca gatatcaccc ctagggtacc aatgtttgtg gtattaggtt
     4681 tgctttgttt tgttttggtc ttttgttgtt ttattaaaga aaagctaaag accgtgtgag
     4741 ccctgctggt gggctttcca tggatgtagc atatggaaga gagtttttat attgcatttt
     4801 tatggattat tttataatgt gggactcagt ctgggaagaa agatgagggt gtctaaaacc
     4861 tgcccatctc cagtgctcca actgagcggc tgccccgaac aggatgtatg ttgggacatg
     4921 gaaagaccgt ggcaccccgc accttcctga gaggcatgtc gacatgcctg tctggagtct
     4981 gtccatctgt ctctgggttt cagatgatca ctggccacca cttgttaagg ctctagccag
     5041 aagggagggt tagggtggaa gagagttatt cctgaagaaa aaagaaaaat tgaaacatca
     5101 ttgtaatgaa gctttttata tttttaaaag ttactattta aaaa
//
LOCUS       NM_001436408            5150 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 7, mRNA.
ACCESSION   NM_001436408 XM_006243215
VERSION     NM_001436408.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5150)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5150)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5150)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5150)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243215.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28643.1,
                                           SRR26643294.32980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1477           JAXUCZ010000008.1  70775659-70775763
            1478-1682           JAXUCZ010000008.1  70782797-70783001
            1683-1699           JAXUCZ010000008.1  70784419-70784435
            1700-1819           JAXUCZ010000008.1  70788295-70788414
            1820-1870           JAXUCZ010000008.1  70789262-70789312
            1871-2023           JAXUCZ010000008.1  70789717-70789869
            2024-2156           JAXUCZ010000008.1  70790230-70790362
            2157-2341           JAXUCZ010000008.1  70790810-70790994
            2342-2418           JAXUCZ010000008.1  70792121-70792197
            2419-2668           JAXUCZ010000008.1  70793078-70793327
            2669-2916           JAXUCZ010000008.1  70793690-70793937
            2917-3064           JAXUCZ010000008.1  70794731-70794878
            3065-3215           JAXUCZ010000008.1  70795421-70795571
            3216-3292           JAXUCZ010000008.1  70796240-70796316
            3293-5150           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5150
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3400
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 7 is encoded by transcript variant 7;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 7"
                     /protein_id="NP_001423337.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG
                     LQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESL
                     RASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAH
                     SPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRN
                     DAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTS
                     PSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAY
                     SFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK
                     GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASP
                     TPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS
                     CIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES
                     SNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQS
                     KESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1504
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1493..1594
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1499..1702
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1655..2152
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1703..1909
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1712..1714
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1736..1738
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1754..1756
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1778..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1799..1801
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1823..1825
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1838..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1856..2497
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1856..2497
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1880..1882
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1892..1894
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1904..1906
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1910..2437
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: SP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1928..1930
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1961..1963
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2039..2041
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2054..2056
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2060..2062
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2066..2068
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2087..2089
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2105..2107
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2333..2335
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2531..2647
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2534..3391
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2534..3391
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2546..2665
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2546..2665
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2669..2788
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2687..2803
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2687..2803
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2801..2920
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2816..2926
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2816..2926
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2927..3046
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2945..3052
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2945..3052
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3050..3169
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3065..3166
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3065..3166
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3173..3292
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3188..3292
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3188..3292
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3296..3394
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3311..3385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3311..3385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1477
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1699
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1819
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1870
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2023
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2156
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2341
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2418
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2668
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2916
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3064
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3215
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3292
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..5150
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcggggta cgtggactcc ccaatctgcc tctcacccag cagcaactcc aggcacagca
     1501 cctctcccat gccacacatg gtcccccggt ccagctgcca ccccacccgt caggcctcca
     1561 acctcctggg attcccccag tgacaggaag cagctctggg ttgctggcac ttggtgccct
     1621 gggaagccaa gcccacttgg cagtgaagga tgagaagaac catcatgaac tggatcacag
     1681 agagagagag tccagcacga acaattctgt gtcaccctca gaaagcctcc gggccagtga
     1741 gaagcaccgg ggctctgcag actacagcat ggaagccaag aagcggaaag cggaagagaa
     1801 agacagcctg agccgatacg acagcgatgg ggacaagagt gatgacctgg tagtggatgt
     1861 ctccaatgag gacccagcga caccccgggt gagcccagca cactcccctc ctgaaaatgg
     1921 gctggacaaa gcccgaggtc tgaagaaaga cgcccccacc agcccagcct ctgtggcttc
     1981 ctccagcagc acgccttcct ccaagaccaa agaccttggt cataatgaca aatcttccac
     2041 acctgggctc aagtccaaca caccaacgcc aaggaacgat gccccaactc caggcaccag
     2101 caccaccccg gggctccggt caatgccggg caaacctcca ggcatggacc cgatagcctc
     2161 ggccctgcgc acacccatct ccctcaccag ctcctatgca gcaccctttg ccatgatgag
     2221 ccaccacgag atgaatggct ccctcaccag cccaagcgcc tatgctggcc tacacaacat
     2281 cccatcccag atgagcgccg ccgcagcagc tgcagccgcc gcctatggcc gatcgccaat
     2341 ggttggtttt gaccctcatc ccccgatgcg ggccacaggc ctgccctcca gtcttgcctc
     2401 cattcctgga gggaaaccgg cgtactcctt ccatgtgagt gccgacgggc agatgcaacc
     2461 tgtgcccttc ccccatgatg cgctagcagg ccccggcatt cccaggcatg cccggcagat
     2521 caacacactc agccatgggg aggtggtatg tgccgtgacc atcagcaacc ccacgaggca
     2581 cgtctacaca ggcggcaagg gctgtgtgaa gatatgggac atcagccagc cgggcagcaa
     2641 gagtcccatc tcccagctgg actgcctgaa cagggacaac tacatccgct catgcaagct
     2701 tctccctgat gggcgcacgc tcattgtggg tggtgaggcc agcacactca ccatctggga
     2761 cctggcctcg cccacgcccc gcatcaaggc tgagctgacg tcctcggctc cagcctgtta
     2821 cgccctggcc atcagtcctg atgccaaagt ctgtttctcc tgctgcagtg atgggaacat
     2881 tgcagtttgg gatctgcaca accagaccct ggtcaggcag ttccagggcc acacggatgg
     2941 ggccagctgt atagacatct ctcatgatgg cactaaactg tggaccgggg gcctggacaa
     3001 cactgtgcgc tcctgggacc tgcgtgaagg gcggcagcta cagcaacacg acttcacctc
     3061 ccagatcttc tccctgggtt actgccccac tggggagtgg ctcgccgtgg gcatggagag
     3121 cagcaacgta gaggttctgc accacaccaa gccggacaag taccaactgc atctgcacga
     3181 gagctgcgtg ctgtccctca agtttgccta ctgtggcaag tggtttgtga gcactgggaa
     3241 agacaacctt ctcaatgcct ggaggacgcc ttacggagcc agcatcttcc agtctaaaga
     3301 atcctcgtcc gtcttgagct gtgatatttc agcggatgac aaatatattg taacgggctc
     3361 tggtgacaag aaggccacag tttacgaggt catctactga acaaggactc taagaggcct
     3421 gtcaaactct gggagacacc cacgcggccc tgacagggag atgctggcca ggccccgagg
     3481 atggcagaag agtgagggac agcattgtgg ggctgccctc cggaaggtgg agaggacgca
     3541 cgcccctttg tggattgctg tgtctgacag acttgaagga ctttctcctc tccccctcac
     3601 cagtgctggc agatgcttca attagatttc tctggaggct tctgctttcg tttcccacac
     3661 agacaccctc atgagtctct gtctcttcct cccctgtctg atctgtcccc tccctactcc
     3721 gggttggggg catgctggag tagacattgt tgtttctggg gaggggcgcc tcgttctgat
     3781 tgtgcagtgc acaaggtttg tgaacaatgt aaataagaga ctgtggttgc tgactggcca
     3841 gtgagggagg aggccccttc ccaccagtgc tcgccgtgta ttttgcctgc tgtatttgta
     3901 acccactcgc ggtggtggct tttctttctt tcttttctta agattttttt taaacagatg
     3961 ttctgtgggg aaagtaggca gagatagaga gtcggggagt ggaatgagaa gcttcctggg
     4021 gatgggcaaa ccagcctggc ccactgggac tgaagtatat ctccacacgg gttttagcac
     4081 catcttcaga tggaatgata ggcagatgga cagacaagct gatggacaga cagtactggg
     4141 atgggccagc ttgggctatt atccacagga acagcgagga tttcctgtgg gtttctctgc
     4201 tccatcttct cttgccttgc cctcacacct cctgacctcc atctctttct gcccccctcc
     4261 ccccgctcgc ctctcccact ggaccccatc tttctctttg gtgcacactc aatcattgtg
     4321 atgaggaatg gaagttcaag ggaactccct ctctgactct cctccgccag cctagaaagg
     4381 attccatatg ggggtgggag ggagacaagc gactcagctc agggagctac cagagaaaaa
     4441 cagcaactgg tgtgggtgct ttttttttta atttgaataa aaataattag aagtgatatc
     4501 ctttgataag atgccgtctc ccctttcctg ctctcagccc tttctgctcc ctgaagccgg
     4561 ggatatggtg acccccaggg tcgtaagtct aagaagatgg gcgggggagc gggctggggg
     4621 ctggggcaga cggaatgtca tctgcagata tcacccctag ggtaccaatg tttgtggtat
     4681 taggtttgct ttgttttgtt ttggtctttt gttgttttat taaagaaaag ctaaagaccg
     4741 tgtgagccct gctggtgggc tttccatgga tgtagcatat ggaagagagt ttttatattg
     4801 catttttatg gattatttta taatgtggga ctcagtctgg gaagaaagat gagggtgtct
     4861 aaaacctgcc catctccagt gctccaactg agcggctgcc ccgaacagga tgtatgttgg
     4921 gacatggaaa gaccgtggca ccccgcacct tcctgagagg catgtcgaca tgcctgtctg
     4981 gagtctgtcc atctgtctct gggtttcaga tgatcactgg ccaccacttg ttaaggctct
     5041 agccagaagg gagggttagg gtggaagaga gttattcctg aagaaaaaag aaaaattgaa
     5101 acatcattgt aatgaagctt tttatatttt taaaagttac tatttaaaaa
//
LOCUS       NM_022178               5608 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus myosin VA (Myo5a), transcript variant 2, mRNA.
ACCESSION   NM_022178
VERSION     NM_022178.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5608)
  AUTHORS   Canclini,L., Cal,K., Bardier,C., Ruiz,P., Mercer,J.A. and
            Calliari,A.
  TITLE     Calcium triggers the dissociation of myosin-Va from ribosomes in
            ribonucleoprotein complexes
  JOURNAL   FEBS Lett 594 (14), 2311-2321 (2020)
   PUBMED   32412091
  REMARK    GeneRIF: Calcium triggers the dissociation of myosin-Va from
            ribosomes in ribonucleoprotein complexes.
REFERENCE   2  (bases 1 to 5608)
  AUTHORS   Maschi,D., Gramlich,M.W. and Klyachko,V.A.
  TITLE     Myosin V functions as a vesicle tether at the plasma membrane to
            control neurotransmitter release in central synapses
  JOURNAL   Elife 7, e39440 (2018)
   PUBMED   30320552
  REMARK    GeneRIF: myosin V acts as a vesicle tether at the plasma membrane,
            rather than a motor transporting vesicles to the release sites, or
            directly regulating vesicle exocytosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5608)
  AUTHORS   Landrock,K.K., Sullivan,P., Martini-Stoica,H., Goldstein,D.S.,
            Graham,B.H., Yamamoto,S., Bellen,H.J., Gibbs,R.A., Chen,R.,
            D'Amelio,M. and Stoica,G.
  TITLE     Pleiotropic neuropathological and biochemical alterations
            associated with Myo5a mutation in a rat Model
  JOURNAL   Brain Res 1679, 155-170 (2018)
   PUBMED   29217155
  REMARK    GeneRIF: This study identified in vivo neuropathological and
            biochemical alterative changes involved in the pathogenesis of a
            spontaneous autosomal recessive movement disorder in a mutant Myo5a
            juvenile rat model.
REFERENCE   4  (bases 1 to 5608)
  AUTHORS   Guatteo,E., Rizzo,F.R., Federici,M., Cordella,A., Ledonne,A.,
            Latini,L., Nobili,A., Viscomi,M.T., Biamonte,F., Landrock,K.K.,
            Martini,A., Aversa,D., Schepisi,C., D'Amelio,M., Berretta,N. and
            Mercuri,N.B.
  TITLE     Functional alterations of the dopaminergic and glutamatergic
            systems in spontaneous alpha-synuclein overexpressing rats
  JOURNAL   Exp Neurol 287 (Pt 1), 21-33 (2017)
   PUBMED   27771352
REFERENCE   5  (bases 1 to 5608)
  AUTHORS   Ultanir,S.K., Yadav,S., Hertz,N.T., Oses-Prieto,J.A., Claxton,S.,
            Burlingame,A.L., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in
            promoting spine synapse development
  JOURNAL   Neuron 84 (5), 968-982 (2014)
   PUBMED   25456499
REFERENCE   6  (bases 1 to 5608)
  AUTHORS   Opartkiattikul,N., Funahara,Y., Fucharoen,S. and Talalak,P.
  TITLE     Increase in spontaneous platelet aggregation in
            beta-thalassemia/hemoglobin E disease: a consequence of splenectomy
  JOURNAL   Southeast Asian J Trop Med Public Health 23 Suppl 2, 36-41 (1992)
   PUBMED   1298991
REFERENCE   7  (bases 1 to 5608)
  AUTHORS   Mercer,J.A., Seperack,P.K., Strobel,M.C., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Novel myosin heavy chain encoded by murine dilute coat colour locus
  JOURNAL   Nature 349 (6311), 709-713 (1991)
   PUBMED   1996138
  REMARK    Erratum:[Nature 1991 Aug 8;352(6335):547]
REFERENCE   8  (bases 1 to 5608)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (bases 1 to 5608)
  AUTHORS   Moore,K.J., Seperack,P.K., Strobel,M.C., Swing,D.A., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     Dilute suppressor dsu acts semidominantly to suppress the coat
            color phenotype of a deletion mutation, dl20J, of the murine dilute
            locus
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8131-8135 (1988)
   PUBMED   3141922
REFERENCE   10 (bases 1 to 5608)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035736.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000008.1  84692949-84693008
            61-171              JAXUCZ010000008.1  84737211-84737321
            172-343             JAXUCZ010000008.1  84741640-84741811
            344-488             JAXUCZ010000008.1  84743618-84743762
            489-645             JAXUCZ010000008.1  84751759-84751915
            646-789             JAXUCZ010000008.1  84758095-84758238
            790-871             JAXUCZ010000008.1  84762533-84762614
            872-979             JAXUCZ010000008.1  84763372-84763479
            980-1086            JAXUCZ010000008.1  84766041-84766147
            1087-1352           JAXUCZ010000008.1  84768764-84769029
            1353-1434           JAXUCZ010000008.1  84770141-84770222
            1435-1575           JAXUCZ010000008.1  84773525-84773665
            1576-1701           JAXUCZ010000008.1  84775345-84775470
            1702-1785           JAXUCZ010000008.1  84777568-84777651
            1786-1947           JAXUCZ010000008.1  84781218-84781379
            1948-2045           JAXUCZ010000008.1  84782283-84782380
            2046-2132           JAXUCZ010000008.1  84784944-84785030
            2133-2241           JAXUCZ010000008.1  84785110-84785218
            2242-2453           JAXUCZ010000008.1  84790157-84790368
            2454-2610           JAXUCZ010000008.1  84791136-84791292
            2611-2850           JAXUCZ010000008.1  84793560-84793799
            2851-3099           JAXUCZ010000008.1  84795682-84795930
            3100-3193           JAXUCZ010000008.1  84798194-84798287
            3194-3342           JAXUCZ010000008.1  84802847-84802995
            3343-3456           JAXUCZ010000008.1  84805130-84805243
            3457-3600           JAXUCZ010000008.1  84811772-84811915
            3601-3654           JAXUCZ010000008.1  84812131-84812184
            3655-3882           JAXUCZ010000008.1  84813217-84813444
            3883-3891           JAXUCZ010000008.1  84814907-84814915
            3892-3992           JAXUCZ010000008.1  84816530-84816630
            3993-4191           JAXUCZ010000008.1  84820462-84820660
            4192-4285           JAXUCZ010000008.1  84824205-84824298
            4286-4432           JAXUCZ010000008.1  84838277-84838423
            4433-4587           JAXUCZ010000008.1  84840700-84840854
            4588-4677           JAXUCZ010000008.1  84846002-84846091
            4678-4828           JAXUCZ010000008.1  84847640-84847790
            4829-5111           JAXUCZ010000008.1  84849736-84850018
            5112-5286           JAXUCZ010000008.1  84852044-84852218
            5287-5367           JAXUCZ010000008.1  84854500-84854580
            5368-5608           JAXUCZ010000008.1  84854833-84855073
FEATURES             Location/Qualifiers
     source          1..5608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5608
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="myosin VA"
                     /db_xref="GeneID:25017"
                     /db_xref="RGD:3143"
     exon            1..60
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..5520
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dilute-opisthotonus; myosin-Va; dilute myosin heavy chain,
                     non-muscle; myosin 5a; unconventional myosin-Va"
                     /codon_start=1
                     /product="unconventional myosin-Va isoform 2"
                     /protein_id="NP_071514.2"
                     /db_xref="GeneID:25017"
                     /db_xref="RGD:3143"
                     /translation="MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEE
                     GKDLEYRLDPKTSELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTY
                     CGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSII
                     VSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSS
                     RFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM
                     LRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILH
                     LGNVGFASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPIS
                     KLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFETFEINSFE
                     QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDL
                     LDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLE
                     KNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRP
                     GQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLR
                     ACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQTCQNVLEKLILDKDK
                     YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQR
                     YVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLARNR
                     YRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIEARS
                     VERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERLQ
                     LSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETEQLVSNLKEE
                     NTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLLNEFSRL
                     EERYDDLKEEMTLMLNVPKPGHKRTDSTHSSNESEYTFSSEFAETEDIAPRTEEPTEK
                     KVPLDMSLFLKLQKRVTELEQEKQLMQDELDRKEEQVLRSKAKEEERPQIRGAELEYE
                     SLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTAVSEELDVR
                     KEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNR
                     LLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEI
                     TRLTNENLDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRP
                     VNIPRKEKDFQGMLEYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHAD
                     YLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMK
                     HNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQG
                     VSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYI
                     VGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQL
                     LQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQVRLRDR
                     KDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFIARV"
     misc_feature    37..39
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4I1; propagated from
                     UniProtKB/Swiss-Prot (Q9QYF3.1); acetylation site"
     misc_feature    52..3858
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    52..3858
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    280..2286
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="class V myosin, motor domain; Region: MYSc_Myo5;
                     cd01380"
                     /db_xref="CDD:276831"
     misc_feature    280..2286
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="class V myosin, motor domain; Region: MYSc_Myo5;
                     cd01380"
                     /db_xref="CDD:276831"
     misc_feature    order(364..390,520..543,658..690,1342..1359)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(364..390,520..543,658..690,1342..1359)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276831"
     misc_feature    364..390
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    364..390
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    520..543
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="P-loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    520..543
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="P-loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    658..690
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch I region; other site"
                     /db_xref="CDD:276831"
     misc_feature    658..690
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch I region; other site"
                     /db_xref="CDD:276831"
     misc_feature    1342..1368
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch II region; other site"
                     /db_xref="CDD:276831"
     misc_feature    1342..1368
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch II region; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(1429..1464,1471..1500)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     misc_feature    order(1429..1464,1471..1500)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     misc_feature    1828..1932
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYF3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1831..1833
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QYF3.1); phosphorylation site"
     misc_feature    1960..2028
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYF3.1);
                     Region: Actin-binding. /evidence=ECO:0000255"
     misc_feature    2086..2118
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276831"
     misc_feature    2086..2118
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(2149..2181,2239..2286)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(2149..2181,2239..2286)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276831"
     misc_feature    3127..3129
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q9QYF3.1); phosphorylation site"
     misc_feature    3346..3474
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYF3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <3505..>4341
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; Region: GumC;
                     COG3206"
                     /db_xref="CDD:442439"
     misc_feature    <3505..>4341
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; Region: GumC;
                     COG3206"
                     /db_xref="CDD:442439"
     misc_feature    4306..4308
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QYF3.1); phosphorylation site"
     misc_feature    4393..5517
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Cargo binding domain of myosin 5a; Region:
                     Myo5a_CBD; cd15478"
                     /db_xref="CDD:271262"
     misc_feature    4393..5517
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Cargo binding domain of myosin 5a; Region:
                     Myo5a_CBD; cd15478"
                     /db_xref="CDD:271262"
     misc_feature    order(4444..4452,4459..4470,4978..4983,5455..5457,
                     5470..5472,5476..5478,5482..5490)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="RILPL2 interface [polypeptide binding]; other site"
                     /db_xref="CDD:271262"
     misc_feature    order(4444..4452,4459..4470,4978..4983,5455..5457,
                     5470..5472,5476..5478,5482..5490)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="RILPL2 interface [polypeptide binding]; other site"
                     /db_xref="CDD:271262"
     misc_feature    order(4528..4530,4537..4542,4549..4554,4561..4566,
                     4573..4575,4666..4668,4720..4737,4741..4746,4753..4755)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="melanophilin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271262"
     misc_feature    order(4528..4530,4537..4542,4549..4554,4561..4566,
                     4573..4575,4666..4668,4720..4737,4741..4746,4753..4755)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="melanophilin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271262"
     misc_feature    4906..4908
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QYF3.1); phosphorylation site"
     misc_feature    5230..5232
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Phosphothreonine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9QYF3.1); phosphorylation
                     site"
     exon            61..171
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            172..343
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            344..488
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            489..645
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            646..789
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            790..871
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            872..979
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1086
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1352
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1434
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1575
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1701
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1785
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1947
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2045
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2132
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2241
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2453
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2610
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2850
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3099
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3193
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3342
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3456
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3600
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3654
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3882
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..3891
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..3992
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4191
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4192..4285
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..4432
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4587
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4677
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4828
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..5111
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5112..5286
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5287..5367
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5608
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccaggcgg ggggcgtcgg cgctgggccc gccatggccg cgtccgagct ctacaccaag
       61 tttgcccggg tttggatacc tgatcctgag gaagtgtgga aatcagctga gttgctcaag
      121 gactataaac ctggagataa ggtgctcctg cttcaccttg aggaagggaa ggatttggaa
      181 taccgtctag atccaaagac cagcgagctc cctcacctac ggaaccctga catacttgtt
      241 ggagaaaatg acctcacagc cctcagctac cttcacgagc ctgctgtgct gcacaatctc
      301 cgcgtccgct tcatcgactc caaactcatt tatacgtatt gtgggatagt cctggtagct
      361 ataaatccct atgagcagct gcctatctat ggagaagata tcattaatgc atacagtggc
      421 cagaacatgg gtgacatgga ccctcacatc tttgcagtag ctgaagaggc ctataaacaa
      481 atggcaaggg acgaacgaaa tcagtccatc attgtaagtg gagagtcagg tgcagggaag
      541 acagtctcgg ctaagtatgc catgaggtac ttcgcaactg taagtggctc tgccagtgag
      601 gccaatgttg aggaaaaggt cttggcctcc aaccccatca tggagtcaat tggaaatgct
      661 aaaacaacca ggaatgataa tagcagccgg tttgggaaat atattgaaat tggttttgac
      721 aagagatatc gaatcatcgg tgccaatatg agaacttacc ttttagagaa atccagagtg
      781 gtgttccagg cagaagagga gagaaactac catatcttct atcagctctg tgcttcggca
      841 aagctacctg agtttaagat gctgcggtta ggaaatgcag atagtttcca ttacacgaag
      901 caaggaggca gccctatgat agaaggagtg gacgatgcga aggagatggc acacaccagg
      961 caggcctgca ctctgctggg aattagtgaa tcttaccaaa tgggaatttt tcggatactt
     1021 gctggcattc ttcacttagg caatgttggg tttgcgtctc gagattcaga cagctgcaca
     1081 atacctccca agcacgagcc tcttatcatt ttctgtgatc ttatgggtgt ggattatgaa
     1141 gagatgtgtc actggctctg ccaccgaaag ctagctaccg ccacagagac gtacatcaag
     1201 cccatctcca agctgcaggc cacaaatgcc cgagacgctt tagcaaagca tatctatgca
     1261 aagctcttta actggattgt cggccatgtc aatcaggctc tccattcagc tgtcaagcag
     1321 cactctttca tcggcgtgct ggacatttat ggatttgaaa catttgagat aaatagtttt
     1381 gaacagttct gcataaatta tgcaaatgaa aagctacagc aacaattcaa catgcatgtc
     1441 ttcaaactgg aacaggagga gtacatgaag gaacaaattc catggacact catagatttc
     1501 tatgataatc agccttgtat caatcttata gaatctaaac tgggtattct agatttgctg
     1561 gatgaggaat gtaagatgcc taaaggtacc gatgacacat gggcccaaaa actatacaac
     1621 acacatttga acaaatgtgc tctctttgag aagccccgca tgtcaaacaa agctttcatc
     1681 atcaaacatt ttgctgacaa agtggagtac cagtgtgaag gttttcttga aaagaataaa
     1741 gacactgttt ttgaagaaca aattaaagtc cttaagtcaa gcaagtttaa gatgctacca
     1801 gaactatttc aagatgacga gaaggccatc agtcccacct ctgccacttc ctcaggacgc
     1861 acacctctca cacgggtacc tgtaaagccc accaagggtc gacctggcca gactgccaaa
     1921 gagcacaaga agacagtggg acttcagttt cgaaactccc ttcacctgct tatggaaacc
     1981 cttaacgcca ctactcctca ctatgttcgc tgtattaagc ccaatgattt caagtttcca
     2041 ttcacatttg atgagaagag agcagtacag cagctaagag catgtggtgt cctggagacc
     2101 atccggatca gcgcagcagg gtttccctca aggtggactt atcaagagtt tttcagccgg
     2161 taccgggtcc taatgaagca aaaggatgtg ctgggagata gaaagcaaac atgccagaat
     2221 gtattagaga aactgatact ggacaaggat aaataccagt ttggtaagac aaagatcttt
     2281 tttcgtgctg gtcaagtggc ctatctagaa aaattgaggg ctgacaaact gagggcggcc
     2341 tgcatccgga tccagaagac gattcgtggg tggctgctga ggaagagata cctgtgtatg
     2401 cagagggcag ccatcacagt gcagcgatac gtgcgtggct atcaggctcg atgctatgct
     2461 aagtttctgc gcagaaccaa ggcagcaacc accattcaga agtactggcg catgtatgtg
     2521 gtccgcagga agtacaagat tagacgagct gccaccattg ttcttcagtc ttatttgaga
     2581 ggctacttgg caagaaatag gtatcgcaag atactccgtg agcacaaagc agtcatcatt
     2641 cagaaacgtg tccgtggctg gctggctcgt acacattata agaggaccat gaaagccatc
     2701 atctaccttc aatgctgctt ccggcggatg atggccaagc gtgagctgaa gaaactcaaa
     2761 attgaggctc gctctgtgga acgctacaag aagctccata ttggcatgga aaacaagatt
     2821 atgcagctgc aacgcaaagt ggatgagcag aataaagact acaaatgcct catggagaaa
     2881 ctgaccaatc tagaaggagt atacaactct gagactgaaa aactacgaaa tgatgtagaa
     2941 cgtcttcagc taagcgagga ggaagctaag gttgccactg ggagagtgct tagtctgcag
     3001 gaagaaattg caaaactccg aaaagacctg gaacaaactc gatcggagaa aaagtccatt
     3061 gaagaacgag cagataaata caaacaagaa actgagcagc tggtgtcaaa cttgaaggaa
     3121 gaaaacactc tgctgaagca ggaaaaggag accctcaatc acctcatggt ggagcaggct
     3181 aaggagatga cagaaactat ggagaggaag ttagtagaag aaacaaaaca actggagctc
     3241 gacctgaatg atgagaggct gaggtatcag aacctcctga atgagttcag tcgtctggag
     3301 gagcgctatg acgacctcaa ggaagagatg accctgatgc tgaatgtgcc taagccagga
     3361 cacaagagaa cagactctac ccacagcagc aatgagtctg aatacacctt cagctcagaa
     3421 tttgcagaaa ctgaagacat tgcaccaagg acagaggagc caactgagaa gaaggtgcct
     3481 ctggatatgt cattgttcct taagctccag aagcgtgtca cagagctgga acaggagaag
     3541 cagttgatgc aggatgagct ggaccgaaag gaggagcagg tgttgcgcag caaggcaaag
     3601 gaagaagaaa gaccacagat tagaggtgct gaactggaat atgagtccct caagcgtcag
     3661 gaactggagt cagaaaacaa aaagctgaag aatgagctga atgagctacg caaagccctg
     3721 agtgagaaga gtgcccccga agtgactgcg ccaggcgcgc ccgcttaccg cgtcctcatg
     3781 gagcagctga cggccgtgag cgaggagctc gatgtccgca aggaggaagt cctcatctta
     3841 aggtctcagc tggtgagcca gaaagaagcc atccaaccca aggatgacaa gaatacaatg
     3901 acagattcca caatactttt ggaagatgta cagaaaatga aagacaaagg tgaaatagca
     3961 caagcatata ttggtttgaa agaaacgaac aggctcttag aatcccagct acagtcgcag
     4021 aagaggagcc atgaaaatga ggctgaggcc ctccgtgggg agatccagag cctaaaggaa
     4081 gaaaacaacc ggcaacagca gctgctggcc cagaacctgc agctgccccc tgaggcccgc
     4141 attgaggcca gcctgcagca tgagatcacc cggctgacca atgaaaacct ggatctgatg
     4201 gaacaacttg aaaagcagga taaaaccgtc cggaaactga agaaacaact aaaagtcttt
     4261 gccaaaaaaa tcggtgaact agaagtgggg cagatggaga acatatcccc aggacagatc
     4321 atcgatgagc ctatccggcc ggtcaacatt ccccggaaag aaaaggattt ccaagggatg
     4381 ctggagtaca agcgggagga cgaacagaag cttgttaaga acctgattct agaactaaag
     4441 ccacgtggtg tggctgtcaa tctgattcca gggttaccgg catatatctt gtttatgtgt
     4501 gtgcgacatg ccgactacct gaacgatgat cagaaagtaa gatcattgct gacatcaaca
     4561 attaacagca tcaaaaaagt cctgaagaaa agaggtgacg attttgaaac tgtctccttc
     4621 tggctctcta acacatgtcg atttttgcac tgtttgaagc aatatagtgg agaagagggc
     4681 ttcatgaaac acaacacgtc tcgccagaat gaacactgcc tcaccaattt tgaccttgct
     4741 gagtatcggc aagtactgag tgacttggcc attcagatct atcagcagct tgtgagggtg
     4801 ttagagaaca ttcttcagcc aatgatagtc tcaggcatgc tagagcatga aacaattcag
     4861 ggagtatctg gggtgaagcc cacaggactc agaaagcgaa cctccagtat cgccgatgag
     4921 ggcacctaca cactggactc catcctgcgg cagctcaact ccttccattc cgtcatgtgt
     4981 cagcatggca tggacccaga gctaatcaag caggtggtca agcagatgtt ctacatcgtg
     5041 ggcgccatca ccctgaacaa cctcctgctg cgcaaggaca tgtgctcctg gagcaaaggc
     5101 atgcagatac ggtacaatgt cagtcaattg gaagaatggc tacgtgacaa gaatctaatg
     5161 aacagtgggg caaaagagac tctggaacct cttatccagg ctgctcagct tttgcaagtg
     5221 aaaaagaaaa ctgacgatga cgcggaagcc atctgctcca tgtgcaacgc tctgaccaca
     5281 gcccagatcg tcaaagtgtt gaatctgtac acacccgtta atgagtttga ggaaagggtc
     5341 tctgtttcat ttatccgcac tatacaggtg cggttacgag acaggaaaga ctctccacag
     5401 ctgctcatgg atgcaaaaca catctttcct gtcactttcc cctttaaccc atcctccctg
     5461 gccctagaaa ccatccagat tccagccagc ctgggcctgg gcttcattgc aagggtctga
     5521 agggctaccc aagcaaatgt agagaacgca tttctcctca aaacatgaac agttgtttcc
     5581 agtgagctac tgaaaataca tttttaaa
//
LOCUS       NM_001109426            1931 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 278 (Tmem278), mRNA.
ACCESSION   NM_001109426 XM_001058568
VERSION     NM_001109426.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001058568.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132273,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1931
                     /gene="Tmem278"
                     /gene_synonym="Tmem88b"
                     /note="transmembrane protein 278"
                     /db_xref="GeneID:680723"
                     /db_xref="RGD:1588243"
     exon            1..538
                     /gene="Tmem278"
                     /gene_synonym="Tmem88b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    209..211
                     /gene="Tmem278"
                     /gene_synonym="Tmem88b"
                     /note="upstream in-frame stop codon"
     CDS             287..784
                     /gene="Tmem278"
                     /gene_synonym="Tmem88b"
                     /codon_start=1
                     /product="transmembrane protein 88B"
                     /protein_id="NP_001102896.1"
                     /db_xref="GeneID:680723"
                     /db_xref="RGD:1588243"
                     /translation="MSDQERETEEDEGVTSDTAPMLPRRRPTDYHISVLATQGLRTLM
                     LSARALAGFLLHLLLPGTVFLLVLLPAAAVVYLGFLCHSRVHPAPGPRCRALLSDRGS
                     AALIVFGFLSLPPLLVLASAARSLLVRRLHLVLPTPARTPDPRRLPRGSEDLADEEKH
                     LCAWV"
     exon            539..1931
                     /gene="Tmem278"
                     /gene_synonym="Tmem88b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acataggagc tgcctgcctt tgcctggtaa agaggcccaa caaggtagtg ggggaaactg
       61 tggtagagga gtagctctgg agactgatat tcagacctag actaaacgga ctagctacct
      121 gatggatagt agactgtcta ctctctgatg gctaggatct aggtgtgaac tgaatctggg
      181 gagggcaaaa ggatctctag cctgggccta gggtacttgg gggttagtcc tgctgcctac
      241 cactgtgatc ttggggggaa acacccttca agggcaacag caggacatga gtgatcagga
      301 aagggagaca gaagaggatg aaggcgttac ctcagacacg gcacccatgc taccccgaag
      361 aaggcctacc gattaccaca tctcagtcct ggccacccaa ggcctcagga ccctgatgct
      421 gtctgcccgg gccctagctg ggttcctgct tcatctgctg ctgcctggga cagtcttcct
      481 gctggtattg ctgccagcag ctgccgttgt ctacctggga ttcctgtgcc actcgagggt
      541 tcatccagcc ccgggtccac gttgcagagc gctgctctca gaccgtggct ccgcggcgct
      601 catagtgttc ggattcctct ctctgccgcc gcttctggtg ctcgcctccg ccgcccgctc
      661 cctcctggtc cggcgactac accttgtact gcctaccccc gcgaggaccc ccgacccgcg
      721 ccgcctgccc agaggcagcg aagatctggc ggacgaggag aaacaccttt gtgcttgggt
      781 ctgacgcctc aaaggtctct cccagttcta ttcgcttgac ccccataaag tggatgacgg
      841 ccgccttggg gctctgagcg cagtgttcga agtctccagg aggtggcaat cgggtccctc
      901 agaagaggga gaaaaggtgt ccctggaaga aaggcgtttg ttctccatcc cctcatgtgg
      961 tccatagcca gctttgcagc catctatgtg ccccgcaaac catgcataat tctagaagct
     1021 ccagtgtagc cagtaacaac cagacttaat ggctcatctt gttgggtcag ttgagtcctc
     1081 caaggtcagc catgaccttg tccaggacga agatcagttg ggtccatggt caaactatta
     1141 tcagatcagg tttgagatag gatctgggat cagtgattca gtgtaagtgc agggtcagca
     1201 tgccgttgta gttaatatat agtttatttt tgttttatgt gcattgatgt ctttttgcct
     1261 gcatgtgtgt gtctatgtga gggtgtcaca agccctggaa gttacagaca gttgtgagtt
     1321 gcaatggggg ttctgggaat tggacctggg tcctctggaa gagcagccca tgatttcttc
     1381 agctcctaat actcagcttg cattcagggt caggtatcca gagctgtatc catgaactag
     1441 agctcatccc ctgaccaggg ttctttcttc tgagacaagc agcagagtaa gagctcattt
     1501 tacaacgtga gtaaatttaa gatttcgaat atcttaaaat attcaatatt ttaaatatct
     1561 ttgtatttgg catgctacag ttttactaat attctcctac gtattcataa attatcatcc
     1621 tccttcccct ccctgtgtcc tatcttctcc ttttcctggg cctcatatat actagaacta
     1681 gaatatctta cttattttta tttttgtaga atatcttact tatttttatt tttagtagtc
     1741 ctaggataaa cttaggtgag ctatatatct accactgagc tatatatcct tagccatgaa
     1801 tatattttta aaacttaaat tatttttaaa atttattatt tttgaatttt atttgtagac
     1861 caggctagcc ttgaactcag ggaatctgcc tgactctgcc tcccaagtac taggattaaa
     1921 agtgtgtgct a
//
LOCUS       NM_017232               4382 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus prostaglandin-endoperoxide synthase 2 (Ptgs2),
            mRNA.
ACCESSION   NM_017232
VERSION     NM_017232.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Toi,M., Toshiya,T., Noguchi,K., Yamanaka,H., Kobayashi,K.,
            Okubo,M., Kishima,K. and Dai,Y.
  TITLE     COX2 expression plays a role in spinal cord injury-induced
            neuropathic pain
  JOURNAL   Neurosci Lett 823, 137663 (2024)
   PUBMED   38286397
  REMARK    GeneRIF: COX2 expression plays a role in spinal cord injury-induced
            neuropathic pain.
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Zhang,X.H., Cui,H., Zheng,S.M., Lu,Y., Yuan,H.W., Zhang,L.,
            Wang,H.H. and Du,R.S.
  TITLE     Electroacupuncture regulates microglial polarization via inhibiting
            NF-kappaB/COX2 pathway following traumatic brain injury
  JOURNAL   Brain Res 1818, 148516 (2023)
   PUBMED   37562566
  REMARK    GeneRIF: Electroacupuncture regulates microglial polarization via
            inhibiting NF-kappaB/COX2 pathway following traumatic brain injury.
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Dourado,T.M.H., Assis,V.O., Awata,W.M.C., de Mello,M.M.B.,
            Carnio,E.C., Castro,M.M. and Tirapelli,C.R.
  TITLE     Mineralocorticoid receptors contribute to ethanol-induced vascular
            hypercontractility through reactive oxygen species generation and
            up-regulation of cyclooxygenase 2
  JOURNAL   Eur J Pharmacol 949, 175723 (2023)
   PUBMED   37059378
  REMARK    GeneRIF: Mineralocorticoid receptors contribute to ethanol-induced
            vascular hypercontractility through reactive oxygen species
            generation and up-regulation of cyclooxygenase 2.
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Abo-El Fetoh,M.E., Abdel-Fattah,M.M., Mohamed,W.R., Ramadan,L.A.A.
            and Afify,H.
  TITLE     Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated
            ADAM-17 signaling in testosterone-induced benign prostatic
            hyperplasia
  JOURNAL   Inflammopharmacology 31 (1), 499-516 (2023)
   PUBMED   36586043
  REMARK    GeneRIF: Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via
            PGE2-mediated ADAM-17 signaling in testosterone-induced benign
            prostatic hyperplasia.
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Xu,S., Yang,J., Wan,H., Yu,L. and He,Y.
  TITLE     Combination of Radix Astragali and Safflower Promotes Angiogenesis
            in Rats with Ischemic Stroke via Silencing PTGS2
  JOURNAL   Int J Mol Sci 24 (3), 2126 (2023)
   PUBMED   36768450
  REMARK    GeneRIF: Combination of Radix Astragali and Safflower Promotes
            Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Kulmacz,R.J. and Wang,L.H.
  TITLE     Comparison of hydroperoxide initiator requirements for the
            cyclooxygenase activities of prostaglandin H synthase-1 and -2
  JOURNAL   J Biol Chem 270 (41), 24019-24023 (1995)
   PUBMED   7592599
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   Hla,T. and Neilson,K.
  TITLE     Human cyclooxygenase-2 cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7384-7388 (1992)
   PUBMED   1380156
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Ryseck,R.P., Raynoschek,C., Macdonald-Bravo,H., Dorfman,K.,
            Mattei,M.G. and Bravo,R.
  TITLE     Identification of an immediate early gene, pghs-B, whose protein
            product has prostaglandin synthase/cyclooxygenase activity
  JOURNAL   Cell Growth Differ 3 (7), 443-450 (1992)
   PUBMED   1419907
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Sirois,J. and Richards,J.S.
  TITLE     Purification and characterization of a novel, distinct isoform of
            prostaglandin endoperoxide synthase induced by human chorionic
            gonadotropin in granulosa cells of rat preovulatory follicles
  JOURNAL   J Biol Chem 267 (9), 6382-6388 (1992)
   PUBMED   1556140
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Hobel,W., Dudeck,J., Bockmann,R.D. and Weber,G.
  TITLE     Improvements of the algorithm for defining QRS onset and offset in
            the Pipberger program
  JOURNAL   Adv Cardiol 21, 181-184 (1978)
   PUBMED   619537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 12, 2022 this sequence version replaced NM_017232.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233596.1, S67722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000013.1  64714063-64714258
            197-313             JAXUCZ010000013.1  64714993-64715109
            314-457             JAXUCZ010000013.1  64715232-64715375
            458-601             JAXUCZ010000013.1  64715993-64716136
            602-783             JAXUCZ010000013.1  64716684-64716865
            784-867             JAXUCZ010000013.1  64717784-64717867
            868-1114            JAXUCZ010000013.1  64717993-64718239
            1115-1401           JAXUCZ010000013.1  64718409-64718695
            1402-1549           JAXUCZ010000013.1  64719084-64719231
            1550-4382           JAXUCZ010000013.1  64719488-64722320
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..4382
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="prostaglandin-endoperoxide synthase 2"
                     /db_xref="GeneID:29527"
                     /db_xref="RGD:620349"
     exon            1..196
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1959
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /EC_number="1.14.99.1"
                     /note="prostaglandin G/H synthase 2; PGH synthase 2;
                     prostaglandin H2 synthase 2; cyclooxygenase-2"
                     /codon_start=1
                     /product="prostaglandin G/H synthase 2 precursor"
                     /protein_id="NP_058928.3"
                     /db_xref="GeneID:29527"
                     /db_xref="RGD:620349"
                     /translation="MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDC
                     TRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYV
                     LTSRSHLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDS
                     KEVLEKVLLRREFIPDPQGTNMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNH
                     VYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQE
                     VFGLVPGLMMYATIWLREHNRVCDILKQEHPEWDDERLFQTSRLILIGETIKIVIEDY
                     VQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQ
                     FLYNNSILLEHGLAHFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLN
                     EYRKRFSLKPYTSFEELTGEKEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGETM
                     VELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFRIINTASIQSLICNNVKGCPFASF
                     NVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL"
     sig_peptide     145..195
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     196..1956
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /product="Prostaglandin G/H synthase 2.
                     /id=PRO_0000023879"
                     /note="propagated from UniProtKB/Swiss-Prot (P35355.1)"
     misc_feature    205..303
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="EGF-like domain; Region: EGF; pfam00008"
                     /db_xref="CDD:394967"
     misc_feature    205..303
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="EGF-like domain; Region: EGF; pfam00008"
                     /db_xref="CDD:394967"
     misc_feature    301..303
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); glycosylation site"
     misc_feature    367..1830
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="Animal prostaglandin endoperoxide synthase and
                     related bacterial proteins; Region:
                     prostaglandin_endoperoxide_synthase; cd09816"
                     /db_xref="CDD:188648"
     misc_feature    367..1830
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="Animal prostaglandin endoperoxide synthase and
                     related bacterial proteins; Region:
                     prostaglandin_endoperoxide_synthase; cd09816"
                     /db_xref="CDD:188648"
     misc_feature    order(451..453,715..717,1135..1137,1144..1149,1159..1161,
                     1165..1167,1243..1245,1255..1257,1261..1263,1654..1656,
                     1666..1668,1678..1683,1690..1695,1702..1704)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:188648"
     misc_feature    order(451..453,715..717,1135..1137,1144..1149,1159..1161,
                     1165..1167,1243..1245,1255..1257,1261..1263,1654..1656,
                     1666..1668,1678..1683,1690..1695,1702..1704)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:188648"
     misc_feature    order(475..477,481..489,508..522,526..528,787..789,
                     1057..1071,1078..1083,1090..1092,1099..1104,1111..1113,
                     1201..1224,1711..1716,1723..1737,1741..1749,1753..1758)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188648"
     misc_feature    order(475..477,481..489,508..522,526..528,787..789,
                     1057..1071,1078..1083,1090..1092,1099..1104,1111..1113,
                     1201..1224,1711..1716,1723..1737,1741..1749,1753..1758)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188648"
     misc_feature    532..534
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); glycosylation site"
     misc_feature    order(544..546,697..699,709..711,721..723,730..738,
                     985..987,1246..1248,1255..1266,1273..1275,1324..1326,
                     1432..1434,1438..1443,1450..1452)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:188648"
     misc_feature    order(544..546,697..699,709..711,721..723,730..738,
                     985..987,1246..1248,1255..1266,1273..1275,1324..1326,
                     1432..1434,1438..1443,1450..1452)
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:188648"
     misc_feature    1330..1332
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); glycosylation site"
     misc_feature    1690..1692
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="Aspirin-acetylated serine.
                     /evidence=ECO:0000250|UniProtKB:P35354; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); other site"
     misc_feature    1837..1839
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="O-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q05769; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); acetylation site"
     misc_feature    1882..1884
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35355.1); glycosylation site"
     exon            197..313
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            314..457
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            458..601
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            602..783
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            784..867
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1114
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1401
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1549
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..4382
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtcaaa ctgagcggag agcttcagga gtacgaagac cctgcctacg aaggaactca
       61 gctctgtgtc ctgccagctc ccccgccagc ttcactgcca ccaacgctgc cacaactgct
      121 gccaccaccg ctgccacctc tgcgatgctc ttccgagctg tgctgctctg cgctgccctg
      181 gcgctcagcc atgcagcaaa tccttgctgt tccaacccat gtcaaaaccg tggtgaatgt
      241 atgagcatag gatttgacca atataaatgt gactgtaccc ggactggatt ctacggtgaa
      301 aactgtacta cgcctgagtt tctgacaaga atcaaattac tgctgaagcc caccccaaac
      361 acagtacact acatcctgac ccacttcaag ggagtctgga acattgtgaa caacattccc
      421 ttccttcgga attcaatcat gagatacgtg ttgacgtcca gatcacattt gattgacagc
      481 ccaccaactt acaatgtgca ctacggttac aaaagttggg aagctttctc caacctctcc
      541 tactacacca gggcccttcc tcctgtggct gatgactgcc caactcccat gggtgtgaaa
      601 ggaaataagg aacttcctga ttcaaaagaa gttctggaaa aggttcttct gaggagagag
      661 ttcatcccgg atccccaagg cacaaatatg atgttcgcat tctttgccca gcacttcact
      721 catcagtttt tcaagacaga tcagaagcga ggacctgggt tcacccgagg actgggccat
      781 ggagtggact taaatcatgt ttacggtgaa actctagaca gacaacataa acttcgactt
      841 ttccaggatg gaaaattgaa atatcaggtc atcggtggag aggtgtatcc tcccacagtc
      901 aaagacactc aggtagacat gatctaccct ccccacgtcc ctgagcacct gcggttcgct
      961 gtggggcagg aagtctttgg tctggtgccg ggtctgatga tgtatgctac catctggctt
     1021 cgggagcaca acagagtgtg tgatatactc aaacaggagc atcctgagtg ggatgacgag
     1081 cgactgttcc aaaccagcag gctcatactg ataggagaga cgatcaagat agtgatcgaa
     1141 gactacgtgc aacacctgag cggttaccac ttcaaactca agttcgaccc agagctgctt
     1201 ttcaaccagc agttccagta tcagaaccgc attgcctctg aattcaacac actctatcac
     1261 tggcatccgc tgctgccgga caccttcaac attgaagacc aggagtacac tttcaaacag
     1321 tttctctaca acaactccat cctccttgaa cacggacttg ctcactttgt tgagtcattc
     1381 accagacaga ttgctggccg ggttgctggg ggaaggaatg ttccaatcgc tgtacaagca
     1441 gtggcaaagg cctccattga ccagagcaga gagatgaaat accagtctct caatgagtac
     1501 cgcaaacgct tctccctgaa accttacaca tcgtttgaag aacttacagg agagaaagaa
     1561 atggctgcag agttgaaagc cctctaccat gacatcgatg ccatggaact gtatcccgcc
     1621 ctgctggtgg aaaagcctcg tccagatgct atctttgggg agaccatggt agaacttgga
     1681 gctccattct ccttgaaagg ccttatgggt aatcccatct gttctcctca atactggaaa
     1741 cctagcacct tcggaggaga agtgggtttt aggatcatca acactgcctc aattcagtct
     1801 ctcatctgca ataatgtgaa agggtgtccc tttgcctctt tcaatgtgca agacccgcag
     1861 cctaccaaga cagccaccat caacgcaagt gcctcccact ccagactaga tgacattaac
     1921 cctacagtac taatcaaaag gcgttcaact gagctgtaag agtctactga ccatatttat
     1981 ttatttatat gaacaattta atttaattat ttaatattta tacagaatgc tttttttcac
     2041 ttaacatctt ctataacaga aggcaatatt cttgaacaat gttccatttg tgaagattcc
     2101 tgtgtttgta ctttaaatat gtgttatccg aaaatgaaag ggaaaaaaag aacactttca
     2161 tttttcggca taagccagtg agaagggaaa tgaattttga tatctttata cttgaatgtc
     2221 agctcatgac tagcttaata agaacaaatg aaaggtgtat gaatatttaa atgctgttac
     2281 aaggagggaa atgtgaatat ttaaatgctg ttacaaggag ggaaatgctg cattgttggt
     2341 tatgactgtg tcatccttac tatgttagga gcaaccgatg tggaattgtt tttaaatctt
     2401 gcatatcttt atctcatcaa agcaaagggg tacaagtcca gttttaaatg agcatgaagg
     2461 cagataccgg caactgtctt tttatttttt aaaagcaatc ttttgaaaca aatgatttgc
     2521 aatgtctaaa tcaggagttg gaatcacttt cgaaagccct tactttcttg agctgtcaaa
     2581 tttgtaccca cacagattaa gcagctacca taaacacaaa tctctaaaac tggggaaaac
     2641 tattatgact gatggttaag ataccatgtc agggatcttt cttttctcag gagtagtgaa
     2701 aagctactat gacaatcaga ccttccttgt acgtcagatt gctggcgtag gaaggtggcg
     2761 gagcccgtga tgttctgtcc taaacgatgg aaaagcttta aagcttgtgt gtgagtggta
     2821 gccagcaaaa cctatcatag caacaaaaga gtccacaaac aaaataacca agaacaaaga
     2881 agggttccaa gctaaagacc gcatcgaggg ttaaactttt gaaggagact ttcagatcct
     2941 cctgtggtgc tggctgtgac ttgccaggct ggacttttaa agagtttttc tgttgcacag
     3001 tatgacacaa cagcccatct ctcaatgcaa aaggtatcag tgggcttctt caaaactttg
     3061 aaatgtcttc cagctcacgg taccagaagt gcagtaggcc ccatgcaatg tgtgagttca
     3121 gcctggatgc cagcatgatg ctctccttac tctgtttctt gtagtcattt tgctctgaga
     3181 aactgctgat tgatctgttt ttgtagctgt gttccaggct cttagtattc tttctttaac
     3241 ctccattaat attttctcta cttgaagttt tacattcagg aaaaacctca gctcaggact
     3301 actgtgtagc tccccttcgg aggaagaagt tactttagac aaaaggcaaa aaaattaaat
     3361 gtatttttca tttgtaatta tatggaaggg ccctaccaag atgctagaat tggagggggt
     3421 tcctgacaag aaagttacat tcttgtcctg aagaattgct ttcttattta aaaacagagt
     3481 cagttagtgg gtagttctgg gcaatagaaa taaatataaa acaataatga caatcattct
     3541 ctacatctca ttatcagctg aggtactgta tattactgaa tttactgaag atagttatgt
     3601 ctttcagaca ttgttgttat aaactatgtt taagcctact acaagtgttt cttttttgca
     3661 ttatgtcaga attgatgtac ctttttttta atgattacct ccctgtacta ctgtgcgaac
     3721 aatcaaacaa aatgatgaga ttaatggtca tggataaatt tcaagaaaac tagtgtattt
     3781 gattgaaaag tttaaagtta gaacttaggc cattggaatt tactcatata gcaaactgcg
     3841 tagagccaat attgactcac ctacacacgt tatacagatt gacattttag acattttgaa
     3901 ggccccgtag gtattttatt agttagaact taattttttg aaaaacatat ccaaagcaca
     3961 ataggcatta gaatttgtgc atcgagaact gattacaaat aatattgata tgtatgtaaa
     4021 taactgagaa gtatgtctta tgaagaaata tattttatta caaaaaatta taaaacattt
     4081 tcaagattat atgctttaaa agtttaagat cagaaaataa tcaactttag aaaaacacgt
     4141 ataaaaattg ttaacatcat tgattaaaaa aaaaaaaaaa aagccaacat gattgttgtg
     4201 aacatcaacc tgctgactga acctgggaat tcaggttaag tatgtgactg ctgccgtgcc
     4261 tcagagaaat ttgtatttaa attaacttat gtaaaaaaaa atcttagaac aaatgtttgt
     4321 ttatttttat acttatttaa gaaattgaaa acttctgaaa ataaagtttg attgtgtctt
     4381 ta
//
LOCUS       NM_001013872            1676 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus MGAT4 family, member F (Mgat4f), mRNA.
ACCESSION   NM_001013872 XM_222643
VERSION     NM_001013872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079259.1.
            
            On Apr 1, 2005 this sequence version replaced XM_222643.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079259.1, CV113050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1676              BC079259.1         1-1676
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1676
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="MGAT4 family, member F"
                     /db_xref="GeneID:289035"
                     /db_xref="RGD:1359351"
     exon            1..54
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    14..16
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="upstream in-frame stop codon"
     exon            55..167
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="alignment:Splign:2.1.0"
     exon            168..295
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1588
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase MGAT4E-like; Mgat4
                     family, member E-like"
                     /codon_start=1
                     /product="Mgat4 family, member E-like precursor"
                     /protein_id="NP_001013894.2"
                     /db_xref="GeneID:289035"
                     /db_xref="RGD:1359351"
                     /translation="MRGCLWRCIRVLASLIILGFLLRENIAVRVEPQFNTFLSEKKKM
                     IQQIAQEEITSEIKNHSKYFIEMQKSSSSHVLQHATYTVLAGSSLQPKRLLTVGIVSM
                     QRSPRTYLLDTMTSLFQASSEQDLEYMLILVLLSDTDPKWLNQTVANISGLFMPHIES
                     GRLLVVHGLLGGSRAESRNHTSPCGKLYSRQKMSSVLLMNLARNLSEYFLMLGDKVHS
                     APRFLSDIFWALSAWNQLPWVILDFSSMTISGKVFHTEDLSCLISFLLLFPKDIPTHL
                     LLSEFRLLLSQNVPIRLSPSIFYRMDSNSEFEDTCFPAEQNDDLGRPDNPAATVFTDM
                     ISFWHTSPQYAYILNDDYFWALDPIKGNYLLVVLDKPQKVIQIAVETGNNVNKLNLLK
                     HGQLLLGYSPMDYPKRCAQYTLVGPLVRGQLDQMVFYEEDSVKEISCIKLLVTESHDY
                     PIKIMQIKVWTEVKEEEN"
     sig_peptide     182..262
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    344..1138
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="Post-GPI attachment to proteins factor 4 and
                     similar proteins; Region: PGAP4-like; cl04660"
                     /db_xref="CDD:471077"
     misc_feature    344..1138
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="Post-GPI attachment to proteins factor 4 and
                     similar proteins; Region: PGAP4-like; cl04660"
                     /db_xref="CDD:471077"
     misc_feature    899..973
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="putative TM2 helix [structural motif]; Region:
                     putative TM2 helix"
                     /db_xref="CDD:409189"
     misc_feature    899..973
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /note="putative TM2 helix [structural motif]; Region:
                     putative TM2 helix"
                     /db_xref="CDD:409189"
     exon            296..458
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1653
                     /gene="Mgat4f"
                     /gene_synonym="Mgat4e-like; Mgat4el"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catccctcaa cattaagttg ttttcttctt gttttcagag aaaaccccat tccagtttct
       61 atggatccta gcagtccaca atgaaggaag tacaccaagt ccttctgtgg ttattcaaaa
      121 ccttgtctat ctaactaaca tagttctggg aaggaaaaga cccaaaaccg ctcctggtgc
      181 catgcgaggc tgcctgtggc ggtgcatcag agtcctggca tccctaatca tcctggggtt
      241 ccttcttcga gagaatatag cagtgcgcgt ggagccgcaa tttaacacat ttctgagtga
      301 aaagaagaaa atgatacagc agatagctca agaggaaatc acctccgaaa tcaagaacca
      361 ttcgaaatac ttcatagaga tgcagaaaag ttccagttcc catgttctcc agcatgctac
      421 ctacacagtt ttggctggat cctctctcca acccaagagg ctgctgacag tggggatcgt
      481 ctcaatgcag cgtagtccca ggacttacct cttggacacc atgacatctt tatttcaagc
      541 ttcctcagaa caggacctgg agtatatgct gatattggtc ctcctgtcag acactgaccc
      601 caaatggctc aaccaaacag ttgccaacat ttcaggtctt tttatgcctc acattgagtc
      661 tgggaggctg ctggtggtcc atggtctact tggtggctcc agagcagaga gcagaaatca
      721 tacctccccc tgtggaaaac tatattctag gcagaaaatg agttctgtcc ttctcatgaa
      781 tttggcccgc aacctctctg agtacttcct gatgctggga gataaagtac atagtgcccc
      841 caggtttctg tctgacatct tctgggcctt gtcagcttgg aaccagctcc cttgggtgat
      901 cctggacttc tccagcatga cgatctctgg gaaggttttt catactgagg acctctcctg
      961 tctcatctcc ttcttgctcc tcttccccaa ggacattcct actcacttgc ttctctctga
     1021 gttcaggctt ctcttgtccc aaaatgtccc tatccgtctc agtccttcca tcttctaccg
     1081 aatggacagt aactctgaat ttgaagacac atgctttcct gcggagcaaa acgacgactt
     1141 gggcagacca gacaaccccg ctgctactgt ctttacagac atgatctcat tttggcatac
     1201 aagtccacag tatgcctaca ttctcaatga tgactacttc tgggccttgg accctatcaa
     1261 aggcaactac ttactggtgg ttctggataa gccacaaaaa gtcatccaga tagcagtaga
     1321 gacgggcaat aatgtgaata agttgaactt actaaaacat gggcaactat tgctgggcta
     1381 cagccccatg gactacccca aacgctgtgc tcaatatacc ttggtaggcc cattggtgag
     1441 aggtcagttg gaccagatgg tattttatga agaagattct gtgaaagaga ttagttgtat
     1501 aaaattgcta gtgaccgaat ctcatgacta ccccatcaag atcatgcaga tcaaagtctg
     1561 gacagaagta aaggaagagg agaactagag ggtactgtga gacttctgta agactgggtc
     1621 taggaaggga gaaataaatc catcaatgac caaaaaaaaa aaaaaaaaaa aaaaaa
//
LOCUS       NM_001429649            4103 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus sarcosine dehydrogenase (Sardh), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001429649 XM_006233733
VERSION     NM_001429649.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4103)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 4103)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   3  (bases 1 to 4103)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 4103)
  AUTHORS   Bergeron,F., Otto,A., Blache,P., Day,R., Denoroy,L., Brandsch,R.
            and Bataille,D.
  TITLE     Molecular cloning and tissue distribution of rat sarcosine
            dehydrogenase
  JOURNAL   Eur J Biochem 257 (3), 556-561 (1998)
   PUBMED   9839943
REFERENCE   5  (bases 1 to 4103)
  AUTHORS   Porter,D.H., Cook,R.J. and Wagner,C.
  TITLE     Enzymatic properties of dimethylglycine dehydrogenase and sarcosine
            dehydrogenase from rat liver
  JOURNAL   Arch Biochem Biophys 243 (2), 396-407 (1985)
   PUBMED   2417560
REFERENCE   6  (bases 1 to 4103)
  AUTHORS   Cook,R.J., Misono,K.S. and Wagner,C.
  TITLE     The amino acid sequences of the flavin-peptides of dimethylglycine
            dehydrogenase and sarcosine dehydrogenase from rat liver
            mitochondria
  JOURNAL   J Biol Chem 260 (24), 12998-13002 (1985)
   PUBMED   4055729
REFERENCE   7  (bases 1 to 4103)
  AUTHORS   Wittwer,A.J. and Wagner,C.
  TITLE     Identification of the folate-binding proteins of rat liver
            mitochondria as dimethylglycine dehydrogenase and sarcosine
            dehydrogenase. Flavoprotein nature and enzymatic properties of the
            purified proteins
  JOURNAL   J Biol Chem 256 (8), 4109-4115 (1981)
   PUBMED   6163778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 24, 2024 this sequence version replaced XM_006233733.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.7398.1,
                                           SRR26643286.9636.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000003.1  30973302-30973374   c
            74-116              JAXUCZ010000003.1  30971525-30971567   c
            117-471             JAXUCZ010000003.1  30968824-30969178   c
            472-650             JAXUCZ010000003.1  30967389-30967567   c
            651-830             JAXUCZ010000003.1  30966172-30966351   c
            831-954             JAXUCZ010000003.1  30962700-30962823   c
            955-1055            JAXUCZ010000003.1  30962452-30962552   c
            1056-1160           JAXUCZ010000003.1  30959047-30959151   c
            1161-1290           JAXUCZ010000003.1  30957866-30957995   c
            1291-1377           JAXUCZ010000003.1  30954163-30954249   c
            1378-1468           JAXUCZ010000003.1  30953836-30953926   c
            1469-1610           JAXUCZ010000003.1  30951736-30951877   c
            1611-1694           JAXUCZ010000003.1  30949484-30949567   c
            1695-1808           JAXUCZ010000003.1  30947283-30947396   c
            1809-1947           JAXUCZ010000003.1  30942955-30943093   c
            1948-2061           JAXUCZ010000003.1  30941162-30941275   c
            2062-2209           JAXUCZ010000003.1  30936272-30936419   c
            2210-2303           JAXUCZ010000003.1  30932290-30932383   c
            2304-2466           JAXUCZ010000003.1  30917468-30917630   c
            2467-2635           JAXUCZ010000003.1  30916574-30916742   c
            2636-2771           JAXUCZ010000003.1  30911991-30912126   c
            2772-4103           JAXUCZ010000003.1  30908621-30909952   c
FEATURES             Location/Qualifiers
     source          1..4103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..4103
                     /gene="Sardh"
                     /note="sarcosine dehydrogenase"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
     exon            1..73
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            74..116
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            117..471
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    129..131
                     /gene="Sardh"
                     /note="upstream in-frame stop codon"
     CDS             138..2897
                     /gene="Sardh"
                     /EC_number="1.5.8.3"
                     /codon_start=1
                     /product="sarcosine dehydrogenase, mitochondrial"
                     /protein_id="NP_001416578.1"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
                     /translation="MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQC
                     TLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERL
                     TSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQ
                     QRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTC
                     TTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWA
                     SSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEA
                     NPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHK
                     PLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSL
                     TDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWER
                     PGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACR
                     TAAAVFNMSYFGKFYLLGADARKAADWLFSADVNRPPGSTVYTCMLNQRGGTESDLTV
                     SCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLG
                     MLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHV
                     PQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAF
                     TCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRA
                     DFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKR
                     VKGIY"
     transit_peptide 138..203
                     /gene="Sardh"
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q64380.2)"
     mat_peptide     204..2894
                     /gene="Sardh"
                     /product="Sarcosine dehydrogenase, mitochondrial.
                     /id=PRO_0000010772"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64380.2)"
     misc_feature    336..1472
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    336..1472
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    657..659
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    1428..1595
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1428..1595
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1578..2888
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1578..2888
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1815..1817
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2463..2465
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2469..2471
                     /gene="Sardh"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UL12; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); phosphorylation site"
     misc_feature    2544..2546
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2790..2792
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2850..2852
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     exon            472..650
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            651..830
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            831..954
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1055
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1160
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1290
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1377
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1468
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1610
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1694
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1808
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1947
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2061
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2209
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2303
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2466
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2635
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2771
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..4103
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaggctg ggactcagag gaagacttag gcaatgtgtt tatccccttc tctctaatcc
       61 gcttgtcagt ctggaatctc ccaggagctt ctggaaaatc taggacgaag actaaggtac
      121 aggagcccta agtccccatg gcttcactga gccgggtcct ccgtgtagct gccacctgtc
      181 ctcgagggag atctgctcgc aacctggggc tacagcccct agccagggag gccaggccca
      241 ccactgagaa gagtgttcca taccagtgca ccctgaagga ggaggcccaa ggtgcctctg
      301 tggtgcccca aggaccaagc cagcccctgc ctagcacagc caatgttgtg gtcattggtg
      361 ggggcagttt gggctgccag actctgtacc acttggccaa gctgggtgta ggtggagttg
      421 tgctgctgga gagagagcga ctgacctctg ggaccacctg gcacacagca ggcctactgt
      481 ggcagctgcg gcccagcgat gtggaagtag agcttctggc tcacacacgg caagtggtga
      541 gccatgatct ggaagaggag actgggcttc acacaggctg gatccagaat ggtggcctct
      601 tcatcgcctc caaccagcag cgcctggatg aatacaagag gctcatgtcg ttgggcaagg
      661 cctacggtat agaatcccat gtgctgagcc ctgcagagac caaggatctg tatccgctga
      721 tgaatgtgga cgacctctat gggaccctgt atgtgcctcg ggatggtacc atggacccgg
      781 ctggcacctg cactaccctc accagagcag cagtggctag gggagctcag gtcattgaaa
      841 actgtgcagt gactggcatc cgtgtgcgga cagacgactt tggagtgcgg cgggtgacag
      901 ctgtggagac tcaacatggc tccatccaga caccctgcgt ggtcaactgt gcaggggtgt
      961 gggcgagctc cgtgggccgg atggctggag tgaaggtccc gctggtggcc atgcaccatg
     1021 cctacgttgt cactgagcgc attgagggga tccagaacat gcccaatgtc cgggatcatg
     1081 atgcttctgt ctacctccgc ctgcaggggg atgccttgtc tgtgggtggc tatgaggcca
     1141 accccatctt ttgggatgag gtgtcagaca aatttgcctt tggcctcttt gacctggact
     1201 gggatgtgtt cactcagcac attgaaggtg ccattaaccg tgtccccgtg ttggagaaaa
     1261 cggggatcaa gtccactgtc tgtggccctg aatccttcac acccgaccat aagcccctga
     1321 tgggggaggc tcctgagctc cgaggcttct tccttggctg tggcttcaac agtgcaggca
     1381 tgatgttggg tggtggctgt ggacaggagc tggcccattg gattgtgcat gggcgcccag
     1441 agaaggacat gtacagctat gacatcaggc gtttccacca ctcgctcacg gaccacccac
     1501 gctggatccg agagcgcagc cacgagtcct atgccaagaa ctactcggtt gtctttcctc
     1561 acgatgagcc cctggcgggc cgcaacatga ggagggaccc tctgcacgag gagctgcttg
     1621 gacaaggctg tgtgtttcaa gaacgacagg gctgggaacg gccaggatgg ttcaaccccc
     1681 aagaaacagc tcaggtccta gactacgact actatggggc ctacggacac caggcacaca
     1741 aggactacgc ctacagcagg ctgctgggcg atgaatatac cttcgacttc ccaccccacc
     1801 actgcgtgat ccagaaggaa tgtctggcct gcagaacggc tgccgccgtg ttcaacatgt
     1861 cttacttcgg gaagttctac cttctggggg cagacgccag gaaggctgca gactggctct
     1921 tctcagcaga tgtcaaccga cccccaggct ccacggtgta cacatgcatg ctgaaccaac
     1981 ggggaggcac cgagagcgac ctgactgtta gctgcctggc ccctggtgcc caggccagtc
     2041 ccctggcccc tgcctttgaa ggggatggct actacctagc cgtaggtggg gctgtggccc
     2101 aacataactg gtcccacata aacacggtgc tgcaggatca ggagttccgg tgccagctta
     2161 tggattgttc tgaagatctg ggcatgctca gtatccaggg cccagccagc cgtgacattc
     2221 tccaggatgt gcttgatgct gacctgagca atgaagcctt ccccttctcc acccaccagc
     2281 tggtgagagc tgctggacac ctggtccgag ccatccggct atcctttgtc ggggagctgg
     2341 gatgggagct gcatgtgccc caagcgtcct gcttgcctgt gtaccgggct gtgatggctg
     2401 caggggcgaa gcacggccta gtcaatgcag gctaccgtgc catcgactcc ctgagcattg
     2461 agaaaggcta tcggcactgg catgcagacc tgaggtccga tgacagcccc ctggaggcag
     2521 ggttggcctt cacctgcaag ctcaagacct cagtgccctt cctaggccga gaggccctgg
     2581 agaagcagcg tgccacaggc ctccgacgac gcctggtgtg cctcactgtg gaagaggagg
     2641 ttcctatgtt cggcctagag gccatctgga gaaatggcca agtggtgggc catgtccgga
     2701 gagctgactt tggattcacc gtgaacaaga ccatcgccta tggctacatc cgagacccca
     2761 gtggagggcc agtctctctg gactttgtga agaatgggga ctatgccttg gagagaatgg
     2821 gggtcaccta tgctgcccag gttcacctga agtctccctt tgatcctgac aacaagcggg
     2881 tgaagggaat ctattgatgg gctgcagggt ggaggctaca gctgctcagg cccctggaaa
     2941 ctgccacact tcccatacgg cctgtggact cctatactgt acaaacagcc ctgtgtcctg
     3001 agacccaaga taagggcaaa acacagactt cccaccctga gcctccatct ggtcctgcta
     3061 actgccacag ctcctaacca gtaccacatg gaccactatg ttcctcctgc tcacagacca
     3121 cacagtggtc tccaatccac tctagccctc ccaaaatgca ccctgcagat gtctgggctc
     3181 aaggtccctg tgtatggtta acccaagata gaagccataa agcaagcagg catccagtct
     3241 gtccctcact tggctgactg cagtgggtag ctggagtgtc tgaagggtag tggattggga
     3301 gagtgagcag ggattgatga gtaatgtctg ccatgggtat aggatggagg acacagagac
     3361 aggtgctgga ctggtacagt ccttcttcgg aatggttgcc ttttagacca gagagaagaa
     3421 ggataagcag gctcttgccc ctagccttcc agctctgcag gagagaaagc cttctgagag
     3481 tcaccaacca gtgacacaga aggcatgtgg catgggattt ggatcaggaa cctcacttac
     3541 aaagaagtgt catactctgc ctcagtttcc cctcaagcca ttgctcatgg gtctggagac
     3601 accaagcttt cactcgtgca taacccagct gcagtgtatg tttccaagga ctttttattt
     3661 ctgtcacaga tgcatggctt cctgatcaag ctctagtgag gggctgctcc agttctgctt
     3721 tgtgagatag agtggcctct tctcccaccc tgtgtaacca tccacatatg tcctcatatc
     3781 aggggcaccc tgcctctcct tcctggggtg aacagccatc acttttctgt agacccaacc
     3841 ttcttcctct gtctcacgcc ctgactgaga aatcgggctg ctgtagctcc ccaaacaaag
     3901 atcaccgtgt agccttatgt gccttgtagt ctaggagaga aggaggccat tgcagtatgg
     3961 agttgggtgt cttaaaccca aagaagtcag cagaagggag atgtgggcac aattgtcctg
     4021 ggtgggctct gaatcttcat agattcacac accacacact gtgccggaaa aaggtcaagt
     4081 taataaaatt ttacgaaacc gtt
//
LOCUS       NM_001308265            5190 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus zinc finger E-box binding homeobox 1 (Zeb1),
            mRNA.
ACCESSION   NM_001308265
VERSION     NM_001308265.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5190)
  AUTHORS   Sun,S., Yan,T., Yang,N., Wu,J. and Liu,Z.
  TITLE     Regulation of osteoclast differentiation and inflammatory signaling
            by TCF8 in periodontitis
  JOURNAL   Oral Dis 30 (4), 2580-2591 (2024)
   PUBMED   37246926
  REMARK    GeneRIF: Regulation of osteoclast differentiation and inflammatory
            signaling by TCF8 in periodontitis.
REFERENCE   2  (bases 1 to 5190)
  AUTHORS   Souza,C.S., Deluque,A.L., Oliveira,B.M., Maciel,A.L.D.,
            Giovanini,C., Boer,P.A., de Paula,F.J.A., Costa,R.S.,
            Franscecato,H.D.C., de Almeida,L.F. and Coimbra,T.M.
  TITLE     Vitamin D deficiency contributes to the diabetic kidney disease
            progression via increase ZEB1/ZEB2 expressions
  JOURNAL   Nutr Diabetes 13 (1), 9 (2023)
   PUBMED   37391399
  REMARK    GeneRIF: Vitamin D deficiency contributes to the diabetic kidney
            disease progression via increase ZEB1/ZEB2 expressions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5190)
  AUTHORS   Zhu,X., Yan,F., Liu,L. and Huang,Q.
  TITLE     ZEB1 regulates bone metabolism in osteoporotic rats through
            inducing POLDIP2 transcription
  JOURNAL   J Orthop Surg Res 17 (1), 423 (2022)
   PUBMED   36123704
  REMARK    GeneRIF: ZEB1 regulates bone metabolism in osteoporotic rats
            through inducing POLDIP2 transcription.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5190)
  AUTHORS   Chen,Y.Y., Jiang,K.S., Bai,X.H., Liu,M., Lin,S.Y., Xu,T., Wei,J.Y.,
            Li,D., Xiong,Y.C., Xin,W.J. and Li,Z.Y.
  TITLE     ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the
            Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment
  JOURNAL   Neurochem Res 46 (8), 2181-2191 (2021)
   PUBMED   34032956
  REMARK    GeneRIF: ZEB1 Induces Ddr1 Promoter Hypermethylation and
            Contributes to the Chronic Pain in Spinal Cord in Rats Following
            Oxaliplatin Treatment.
REFERENCE   5  (bases 1 to 5190)
  AUTHORS   Sun,D., Liu,X., Zhu,L. and Zhang,B.
  TITLE     Zinc-finger E-box-binding homeobox 1 alleviates acute kidney injury
            by activating autophagy and the AMPK/mTOR pathway
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33846788
  REMARK    GeneRIF: Zincfinger Eboxbinding homeobox 1 alleviates acute kidney
            injury by activating autophagy and the AMPK/mTOR pathway.
REFERENCE   6  (bases 1 to 5190)
  AUTHORS   Gong,S.G. and Eulenberg,R.L.
  TITLE     Palatal development in Twirler mice
  JOURNAL   Cleft Palate Craniofac J 38 (6), 622-628 (2001)
   PUBMED   11681996
REFERENCE   7  (bases 1 to 5190)
  AUTHORS   Cabanillas,A.M., Smith,G.E. and Darling,D.S.
  TITLE     T3-activation of the rat growth hormone gene is inhibited by a zinc
            finger/homeodomain protein
  JOURNAL   Mol Cell Endocrinol 181 (1-2), 131-137 (2001)
   PUBMED   11476947
REFERENCE   8  (bases 1 to 5190)
  AUTHORS   Takagi,T., Moribe,H., Kondoh,H. and Higashi,Y.
  TITLE     DeltaEF1, a zinc finger and homeodomain transcription factor, is
            required for skeleton patterning in multiple lineages
  JOURNAL   Development 125 (1), 21-31 (1998)
   PUBMED   9389660
REFERENCE   9  (bases 1 to 5190)
  AUTHORS   Higashi,Y., Moribe,H., Takagi,T., Sekido,R., Kawakami,K.,
            Kikutani,H. and Kondoh,H.
  TITLE     Impairment of T cell development in deltaEF1 mutant mice
  JOURNAL   J Exp Med 185 (8), 1467-1479 (1997)
   PUBMED   9126927
REFERENCE   10 (bases 1 to 5190)
  AUTHORS   Cabanillas,A.M. and Darling,D.S.
  TITLE     Alternative splicing gives rise to two isoforms of Zfhep, a zinc
            finger/homeodomain protein that binds T3-response elements
  JOURNAL   DNA Cell Biol 15 (8), 643-651 (1996)
   PUBMED   8769566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2024 this sequence version replaced NM_001308265.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51583.1, SRR26643296.36810.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000017.1  56810573-56810653   c
            82-282              JAXUCZ010000017.1  56702472-56702672   c
            283-444             JAXUCZ010000017.1  56661355-56661516   c
            445-647             JAXUCZ010000017.1  56658424-56658626   c
            648-753             JAXUCZ010000017.1  56656453-56656558   c
            754-2558            JAXUCZ010000017.1  56650728-56652532   c
            2559-2736           JAXUCZ010000017.1  56648490-56648667   c
            2737-5190           JAXUCZ010000017.1  56644397-56646850   c
FEATURES             Location/Qualifiers
     source          1..5190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..5190
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="zinc finger E-box binding homeobox 1"
                     /db_xref="GeneID:25705"
                     /db_xref="RGD:3831"
     exon            1..81
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3353
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="zfhep; zinc finger homeodomain enhancer-binding
                     protein; TCF-8; transcription factor 8 (represses
                     interleukin 2 expression)"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 1"
                     /protein_id="NP_001295194.1"
                     /db_xref="GeneID:25705"
                     /db_xref="RGD:3831"
                     /translation="MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEE
                     ESVTDAADCEGGVPDDELPTDQTVLPGGSDRAGSAKNCWQDDVKDDECDSDAENEQNH
                     DPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASGHDDNGTPDAFSQLLTCPYCDRGYK
                     RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNR
                     KFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLM
                     PVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYE
                     FKPIVVASGINCSTPLQNGVFSGGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDI
                     QNVLKVAVDGNIIRQVLENNQASLASKEQEAVSASSIQQGGHSVISAISLPLVDQDGT
                     TKIIINYSLEQPGQLQVVPQNLKKENPAPPKSCKSEKSPEDLTVKSEKDKSFDGAADE
                     STCLLCEDCPGDLNALPELKHYDPEHPAQPPPPAPATEKPESSASSAGNGDLSPSQPP
                     LKNLLSLLKAYYALNAQPSTEELTKIADSVNLPLDVVKKWFEKMQAGQIPGQSLEPPS
                     PGPGSGNIPAKTEEQPQPVDGNEPQEDSTRGQSPLKMTSSPVLPVGSAINGSRSCTSS
                     PSPLNLSSARNPQGYSCVSEGTQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYS
                     VQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQ
                     NSVPCLRALAANKQTILIPQVAYTYSATVSPAMQEPPVKVIQPNGNQDERQDTSSEGV
                     SVEDQNDSDCTPPKKKTRKAENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGIC
                     RKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDA
                     MEQEDTGPEALPEVLPTELVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEE
                     LQEDKECENPQEEEEEEEEEEEEEEEEEEEEAEEAEHEAAAAKTGGAVEEEAAQQAGS
                     FQQKASGSESKRLSEEKTNEA"
     misc_feature    24..341
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    48..>473
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="GET complex subunit GET2; Region: GET2; pfam08690"
                     /db_xref="CDD:400847"
     misc_feature    48..>473
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="GET complex subunit GET2; Region: GET2; pfam08690"
                     /db_xref="CDD:400847"
     misc_feature    114..116
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    120..122
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    390..452
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    477..542
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    477..542
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    561..629
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    561..629
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    567..629
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    567..629
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    681..749
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    681..749
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    687..749
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    687..749
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    723..794
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    723..794
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    855..944
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    900..902
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q64318; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    927..929
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P37275; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    1425..1526
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1596..1721
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1701..1844
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1701..1844
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1863..2156
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1992..1994
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P37275; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2013..2015
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q64318; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2034..2036
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q64318; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2055..2057
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2061..2063
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P37275; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2067..2069
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q64318; propagated from
                     UniProtKB/Swiss-Prot (Q62947.2); phosphorylation site"
     misc_feature    2523..2642
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2670..2732
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2670..2732
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2685..2687,2691..2693,2697..2699,2703..2708,
                     2715..2720,2727..2729,2769..2771,2775..2777,2787..2792,
                     2799..2804,2811..2813,2853..2855,2859..2861,2865..2867,
                     2871..2876,2883..2888)
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2685..2687,2691..2693,2697..2699,2703..2708,
                     2715..2720,2727..2729,2769..2771,2775..2777,2787..2792,
                     2799..2804,2811..2813,2853..2855,2859..2861,2865..2867,
                     2871..2876,2883..2888)
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2706..2783
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2706..2783
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2754..2816
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2754..2816
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2790..2867
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2790..2867
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2838..2891
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2838..2891
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2925..3350
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62947.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            82..282
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            283..444
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            445..647
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            648..753
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2558
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2736
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..5190
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttagacac aagcgagagg atcatggcgg atggccccag gtgtaagcgc agaaagcagg
       61 cgaacccgcg gcgcaataac gttacaaatt ataatactgt ggtagaagca aattcagatt
      121 cggatgatga agacaaactc catattgtgg aagaagaaag tgtcacagat gcagctgact
      181 gtgaaggtgg tgtgccagat gatgagctgc caacagacca gacagtgtta ccaggaggca
      241 gtgacagggc gggcagtgcc aagaactgct ggcaagacga cgtaaaagat gacgaatgcg
      301 actcagatgc agaaaacgag caaaaccatg atcccaacgt ggaagagttc ctgcagcaac
      361 aggacaccgc ggtcatctac cctgaggcac ccgaggagga ccagcggcag ggcacgccag
      421 aagccagcgg tcatgatgac aatggaacac cagatgcatt ttcccagttg ctcacctgcc
      481 cgtattgtga tagaggctac aagcgcttta cctctttgaa agaacacatt aagtaccgcc
      541 atgagaagaa tgaagacaac ttcagctgct ccctgtgcag ttacaccttt gcatacagaa
      601 cccagcttga acgtcatatg acatcacata agtcaggaag agagcaaaga catgtgacac
      661 agtctggagg taaccgtaag ttcaagtgca ccgagtgtgg gaaagcgttc aagtacaaac
      721 accatctgaa ggagcactta cggatccaca gtggagagaa gccatatgaa tgcccaaact
      781 gcaagaaacg tttttcccat tctggctctt atagctcaca cataagcagt aagaagtgta
      841 ttagcttgat gcctgtgaat ggtaggccca gatcaggact caagacatct cagtgttcct
      901 cgccatctct ttcaacatca ccaggcagtc ccacacgccc acagatacgg cagaagatag
      961 agaataaacc ccttcaagaa ccgctttctg taaaccaaat caaaactgaa cctgtggatt
     1021 atgagttcaa acccatagtg gttgcttcag gaatcaactg ttcaacccct ttacaaaatg
     1081 gggtttttag cggtggtggc caattgcagg caaccagttc tcctcagggt gtggtgcaag
     1141 ctgttgttct gccaacagtt ggtttggtat ctcccataag tatcaactta agtgacattc
     1201 agaatgtact taaagtggct gtagatggta acataatacg acaggttttg gagaataatc
     1261 aagccagtct tgcatccaaa gagcaagaag ccgtgagtgc ttcatccatc cagcagggcg
     1321 gccattctgt catttctgcc atcagtcttc ctttagttga tcaggatggc acaaccaaaa
     1381 tcatcatcaa ctacagtctt gagcagcccg gccaacttca ggttgttccc cagaatctaa
     1441 agaaagaaaa cccagcccct ccaaagagct gcaaaagtga gaagtcacca gaagatctta
     1501 ctgtcaagtc agagaaggac aaaagctttg atggggctgc ggatgagagc acttgccttt
     1561 tgtgtgagga ctgcccagga gacctcaatg cacttccaga actaaagcac tatgacccag
     1621 agcaccctgc tcaacctcca ccccctgccc cagccaccga gaagccagag tcctctgctt
     1681 catcagccgg caatggagat ttgtctccca gtcagccacc tttaaagaac cttctgtcgc
     1741 tcttaaaagc ctactatgct ctgaatgcac agccaagcac agaagagctc accaagattg
     1801 ccgattctgt gaacctgccg ctggatgtag ttaaaaagtg gtttgaaaag atgcaagctg
     1861 gacagattcc cgggcagtct cttgaaccac cttctccagg accggggtca ggaaacatcc
     1921 ctgcaaaaac tgaggagcag cctcaacctg tggatggaaa tgagccccag gaagacagca
     1981 cacgtggaca gagtcctctc aagatgacaa gctctccagt tttaccagta ggatcagcca
     2041 ttaacggttc cagaagttgc acatcatccc catcccctct aaacctttcc tcagccagga
     2101 acccgcaggg ttactcttgt gtgtcagagg gtacccagga ggagccccaa gtagaacctc
     2161 ttgatctctc actaccaaag caacagggag agttactgga aaggtcgaca gtcagtagcg
     2221 tttaccagaa cagtgtttat tctgtccagg aagaaccctt gaacttgtct tgtgcaaaaa
     2281 aggagccaca aaaggacagt tgtgttacag actcagaacc agttgtaaat gtagtcccac
     2341 caagtgccaa ccccataaac attgctattc ctacagtcac tgcccagtta cccacaatcg
     2401 tggccatcgc tgaccagaac agtgttccgt gcttacgggc actcgctgcc aacaagcaga
     2461 ctattctgat tccccaagtg gcatatacat actccgctac agtcagccca gccatgcagg
     2521 agccaccagt gaaggtgatc cagccaaatg gaaaccagga tgaaagacaa gacactagct
     2581 cagaaggagt ctccgtggag gaccagaatg actctgactg cacgccaccc aaaaagaaaa
     2641 ctcggaaggc agagaatggg atgtacgcat gtgacctgtg tgacaagata tttcagaaga
     2701 gcagctccct gctgagacac aaatatgagc atacaggtaa gaggccccac gagtgcggaa
     2761 tctgtagaaa ggcatttaaa cacaagcatc atttgattga gcacatgcga ctgcactctg
     2821 gggaaaagcc ctaccaatgt gacaagtgtg gcaagcgctt ctcacactcg gggtcttact
     2881 ctcaacacat gaatcaccgc tactcctact gcaagagagg agctgaagac agagatgcca
     2941 tggagcagga agacactggg ccggaagccc tgccggaagt cctgcccact gagcttgttg
     3001 gtgcccgggc atctccctca caggctgact cggacgagag agaaagtttg acaagggaag
     3061 aggatgaaga cagtgaaaag gaggaggagg aggaggataa agagatggaa gaattgcagg
     3121 aagacaagga atgtgagaac ccacaggagg aggaggagga ggaagaggag gaagaagaag
     3181 aggaggagga ggaagaggaa gaggaggcag aggaagctga gcatgaggcg gcagcagcca
     3241 agactggggg tgcagtggag gaggaagcgg ctcagcaggc aggcagcttc cagcagaagg
     3301 ccagcgggag cgagagcaag cgactgtctg aagagaagac aaatgaagcc taggagctct
     3361 tccaaaagga agtcctgctt ggtaatgaaa tttgctctat attacccacg cttttcatgg
     3421 aaacatggct cctgtgctat ggttcctgct cactactgtg taatgtcaga actgaaaaac
     3481 aaaatactaa aaaaaaaaaa aaaaaaaaaa aaaaaaatcc gggtgtgcct gaacctcaaa
     3541 cctagtaatt tttcatgcag ttttcaaagt taggaacaag tttgtaacat gaagcagatt
     3601 agaaaacaaa ggtttctcag caggttacag gaagctcgat gggcatctgg cttggctggc
     3661 agtattatca ctcttacgtt gttcattcta agctgtacaa tgggagaaat tttataattt
     3721 tttattggta aacatatgct aaatccactt cagtatttta ttatgttttt tttaaatgtg
     3781 agaacttctg cactacagaa ttcccttcac cgagcagtag aaagcagttc agaccgtgct
     3841 ggctacctgc tgccacccca ccagtcagga ggtaggacct ctgaccttag atgccatgct
     3901 gccatctaac gtgcatcgct agccttaagg aagcagagag aggagcggga gtttcttact
     3961 cgtgtgatct taaatggagt tcaaaggttg tccttgagtt ctgactgcag ggacggccag
     4021 tgttgatgtg gcgaggacgg cagaggcggc agaatcagtg ttcgtgattg tgtttgcgta
     4081 cgtgacagca actatgaagg atctatagga agcgctgtgt ccctttggcc ttaagcaaga
     4141 cctatgtgct gtaagtgcca ttgtcagtgt ttcaaggctg taacagcctt cactcagtgt
     4201 gtggcctaca ataactagca tttgttgatt tgtttgttgt gtcaaaattc ccaaataaaa
     4261 ctcaaaccac tgactctgtc agagaagctg aagcactggg acatttcaca cttctgttcc
     4321 tcagtattca tgttacgttg attgactcag aaatctctac agaaataaaa gggaaattct
     4381 ccaactactt agtccatgta cttgcgtgtc agacatggat aagccattgg ttcttggctc
     4441 acagccattt ccaaatgtta gttattacgg acccaggtga tgaacagcag ctgattttta
     4501 cctaccagta ttattttatt tcttttagtt tgtagatctg tgcaacattt ttgtactgta
     4561 cgtcttcaag cctggcagta ttaataccct tcttactgac acgtactttt agttttagaa
     4621 aacttttata tttatgtgtc ttatttttat atttctttat ttattacaca gtgtagtgta
     4681 taatactgta gtttgtatta atacaataat atattttagt atgaaatttt ggaaagttga
     4741 taagatttaa agtagagatg caattggttc tcgtgcattg agatttgatt taacagtgtt
     4801 ctgttaacat ttatactcgc ctcggactgt agaacagagt ttaaatggga atgtattagt
     4861 tttacaacta caatcaagtc attctccctt tacccagttt ttaatatgaa actcttacac
     4921 tttgaaactc actgtgtgtg actcatagca tgctgctctt ctgttaagag ttagcccagc
     4981 cataactcat tcccttagca agccaaatta gaattgcctt ctgtaaacag tgttgggaac
     5041 aatgtttaac atggtgtgcc aatttgttcc tgtatccatg tatgtaagct accaatccga
     5101 ctcttccttt taagttcctt gttacaccat ggtcattttc tagtttttta ccagactccc
     5161 agctcacaat aaacgcatca acaagcctga
//
LOCUS       NM_001002827            6483 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus notch receptor 4 (Notch4), mRNA.
ACCESSION   NM_001002827 XM_579090
VERSION     NM_001002827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6483)
  AUTHORS   Guo,M., Zhang,M., Cao,X., Fang,X., Li,K., Qin,L., He,Y., Zhao,J.,
            Xu,Y., Liu,X. and Li,X.
  TITLE     Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling
            pathways in hypoxic pulmonary hypertension
  JOURNAL   Respir Res 23 (1), 6 (2022)
   PUBMED   35016680
  REMARK    GeneRIF: Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK
            signaling pathways in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6483)
  AUTHORS   Xia,Z., Wang,J., Yang,S., Liu,C., Qin,S., Li,W., Cheng,Y., Hu,H.,
            Qian,J., Liu,Y. and Deng,C.
  TITLE     Emodin alleviates hypertrophic scar formation by suppressing
            macrophage polarization and inhibiting the Notch and TGF-beta
            pathways in macrophages
  JOURNAL   Braz J Med Biol Res 54 (8), e11184 (2021)
   PUBMED   34320121
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6483)
  AUTHORS   Yang,G.S., Zhou,X.Y., An,X.F., Liu,X.J., Zhang,Y.J. and Yu,D.
  TITLE     Mild hypothermia inhibits the Notch 3 and Notch 4 activation and
            seizure after stroke in the rat model
  JOURNAL   Pathol Res Pract 214 (7), 1008-1016 (2018)
   PUBMED   29754932
  REMARK    GeneRIF: mild hypothermia inhibits Notch 3 and Notch 4 activation
            and seizure after stroke in the rat model
REFERENCE   4  (bases 1 to 6483)
  AUTHORS   Pierscianek,D., Wolf,S., Keyvani,K., El Hindy,N., Stein,K.P.,
            Sandalcioglu,I.E., Sure,U., Mueller,O. and Zhu,Y.
  TITLE     Study of angiogenic signaling pathways in hemangioblastoma
  JOURNAL   Neuropathology 37 (1), 3-11 (2017)
   PUBMED   27388534
REFERENCE   5  (bases 1 to 6483)
  AUTHORS   Pierscianek,D., Michel,A., Hindy,N.E., Keyvani,K., Dammann,P.,
            Oezkan,N., Mueller,O., Sure,U. and Zhu,Y.
  TITLE     Activation of multiple angiogenic signaling pathways in
            hemangiopericytoma
  JOURNAL   Brain Tumor Pathol 33 (3), 200-208 (2016)
   PUBMED   26951238
REFERENCE   6  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Ho,J., Rossant,J. and Kitajewski,J.
  TITLE     Vascular patterning defects associated with expression of activated
            Notch4 in embryonic endothelium
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5643-5648 (2001)
   PUBMED   11344305
REFERENCE   7  (bases 1 to 6483)
  AUTHORS   Suzuki,T., Aoki,D., Susumu,N., Udagawa,Y. and Nozawa,S.
  TITLE     Imbalanced expression of TAN-1 and human Notch4 in endometrial
            cancers
  JOURNAL   Int J Oncol 17 (6), 1131-1139 (2000)
   PUBMED   11078798
REFERENCE   8  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Closson,V., Wu,G., Roux,F., Weinmaster,G. and
            Kitajewski,J.
  TITLE     Notch4 and Jagged-1 induce microvessel differentiation of rat brain
            endothelial cells
  JOURNAL   Microvasc Res 60 (2), 91-103 (2000)
   PUBMED   10964583
REFERENCE   9  (bases 1 to 6483)
  AUTHORS   Uyttendaele,H., Soriano,J.V., Montesano,R. and Kitajewski,J.
  TITLE     Notch4 and Wnt-1 proteins function to regulate branching
            morphogenesis of mammary epithelial cells in an opposing fashion
  JOURNAL   Dev Biol 196 (2), 204-217 (1998)
   PUBMED   9576833
REFERENCE   10 (bases 1 to 6483)
  AUTHORS   Sarkar,N.H., Haga,S., Lehner,A.F., Zhao,W., Imai,S. and Moriwaki,K.
  TITLE     Insertional mutation of int protooncogenes in the mammary tumors of
            a new strain of mice derived from the wild in China: normal- and
            tumor-tissue-specific expression of int-3 transcripts
  JOURNAL   Virology 203 (1), 52-62 (1994)
   PUBMED   8030284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883044.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132264
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..6483
                     /gene="Notch4"
                     /note="notch receptor 4"
                     /db_xref="GeneID:406162"
                     /db_xref="RGD:1303282"
     exon            1..227
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Notch4"
                     /note="upstream in-frame stop codon"
     CDS             164..6049
                     /gene="Notch4"
                     /note="neurogenic locus notch homolog protein 4; notch 4"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 4
                     precursor"
                     /protein_id="NP_001002827.1"
                     /db_xref="GeneID:406162"
                     /db_xref="RGD:1303282"
                     /translation="MQRQWLLLLLLPLSFPVILTRELLCGGSPEPCANGGTCLRLSQG
                     QGTCQCAPGFLGETCQFPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTC
                     PSGFTGDRCQSPLEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQLRDFCSAN
                     PCANGGVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHNTLGSFQCL
                     CPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDD
                     CVRNQCQNGATCQDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAG
                     GFHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDM
                     CLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCI
                     NTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCE
                     VEINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQ
                     PGAFHCECLPGFEGPRCETEADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQLCEVP
                     LCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTG
                     PECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCSEEITACHSGPCLNGGS
                     CSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCMSKPGTFFCHCATGFQGLH
                     CEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCARKPCPHTARC
                     LQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNGGLCIDTGSSYFCRC
                     PPGFEGKLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCSKVHDACQSGP
                     CHNHGTCTPRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCHSLANAFYCQC
                     LPGHTGQRCEVEMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTCSRKAPACG
                     NHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCMHNGSCTETP
                     GLGNPGFQCTCPPDSPGPRCQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCSLGVP
                     DPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPPTCTPAYDQYCRDHFHNG
                     HCEKGCNNAQCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVLSLTLR
                     VGLWVRKDSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQTPGKETESLGAGFV
                     VVMGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTGS
                     PATRLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPH
                     RRRPPLGEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEKTASASRCQLWPLRSGCEG
                     LPQAVMLTPPQECESELPDSDTCGPDGVTPLMSAVFCGGVQSTTVQRLGLGNPEPWEP
                     LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVA
                     ADAREVCQLLLASRQTAVDARTDDGTTPLMLAARLAVEDLVEELIAARADVGARDKRG
                     KTALHWAAAVNNARAARCLLQTGADKDAQDSREQTPLFLAAREGAVEVAQLLLEIGAA
                     RGLRDQAGLAPADVARQRSHWDLLTLLEGAGPITQEARSHARNTPGGGAAPRCRTLSA
                     GARPRGGGACLQARTWSVDLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGA
                     RVSQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGR
                     NQN"
     sig_peptide     164..223
                     /gene="Notch4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    734..829
                     /gene="Notch4"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    734..829
                     /gene="Notch4"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    order(734..736,743..745,791..793)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(734..736,743..745,791..793)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1094..1210
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1094..1210
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1094..1096,1103..1105,1154..1156)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1094..1096,1103..1105,1154..1156)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1217..1324
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1217..1324
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1217..1219,1226..1228,1268..1270)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1217..1219,1226..1228,1268..1270)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1448..1573
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1448..1573
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1448..1450,1457..1459,1514..1516)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1448..1450,1457..1459,1514..1516)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1577..1687
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1577..1687
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1577..1579,1586..1588,1628..1630)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1577..1579,1586..1588,1628..1630)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1694..1801
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1694..1801
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1805..1915
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1805..1915
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1805..1807,1814..1816,1856..1858)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1805..1807,1814..1816,1856..1858)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1925..2029
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1925..2029
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    <2249..2332
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    <2249..2332
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2456..2563
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2456..2563
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    <2591..2680
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    <2591..2680
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2837..2935
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2837..2935
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2942..3046
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2942..3046
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3059..3163
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3059..3163
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3167..3283
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3167..3283
                     /gene="Notch4"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(3167..3169,3176..3178,3224..3226)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(3167..3169,3176..3178,3224..3226)
                     /gene="Notch4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    3782..3889
                     /gene="Notch4"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    3782..3889
                     /gene="Notch4"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    3896..4006
                     /gene="Notch4"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    3896..4006
                     /gene="Notch4"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    4034..4183
                     /gene="Notch4"
                     /note="NOTCH protein; Region: NOD; pfam06816"
                     /db_xref="CDD:462014"
     misc_feature    4034..4183
                     /gene="Notch4"
                     /note="NOTCH protein; Region: NOD; pfam06816"
                     /db_xref="CDD:462014"
     misc_feature    4469..4696
                     /gene="Notch4"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in neurogenic locus notch homolog protein 4 (Notch4) and
                     similar proteins; Region: JMTM_Notch4; cd21705"
                     /db_xref="CDD:411988"
     misc_feature    4469..4696
                     /gene="Notch4"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in neurogenic locus notch homolog protein 4 (Notch4) and
                     similar proteins; Region: JMTM_Notch4; cd21705"
                     /db_xref="CDD:411988"
     misc_feature    <4994..5647
                     /gene="Notch4"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <4994..5647
                     /gene="Notch4"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    5039..5131
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5039..5131
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(5042..5044,5054..5059,5066..5074,5078..5083,
                     5093..5095,5102..5104,5129..5131,5135..5137,5141..5143,
                     5153..5158,5165..5173,5177..5182,5192..5194,5204..5206,
                     5231..5233,5237..5239,5243..5245,5255..5260,5267..5275,
                     5279..5284,5294..5296,5303..5305,5330..5332)
                     /gene="Notch4"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(5042..5044,5054..5059,5066..5074,5078..5083,
                     5093..5095,5102..5104,5129..5131,5135..5137,5141..5143,
                     5153..5158,5165..5173,5177..5182,5192..5194,5204..5206,
                     5231..5233,5237..5239,5243..5245,5255..5260,5267..5275,
                     5279..5284,5294..5296,5303..5305,5330..5332)
                     /gene="Notch4"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    5135..5233
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5135..5233
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5237..5332
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5237..5332
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5336..5431
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5336..5431
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5435..5530
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5435..5530
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5534..5644
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5534..5644
                     /gene="Notch4"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            228..309
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..605
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..953
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1076
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1313
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1469
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1664
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1778
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1892
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2015
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2175
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2321
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2474
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2592
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2680
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2831
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3016
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3269
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3382
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3906
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4290
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4466
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..4686
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4756
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4895
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5191
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5339
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5437
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..6483
                     /gene="Notch4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacattgtgt gactcaggaa acagctcaga ctgaggcgtg cagcaggccc aggaggaaga
       61 agggcggtag aggcagagga ggtggccttg cctggccaca aacgctctga gggtccttgc
      121 ctggagaggg agaggagacc gagccaggga caggcgctct gggatgcagc gccagtggct
      181 gctgcttctg ctcttgccgc tcagcttccc agtcatcctg accagagagc ttctgtgtgg
      241 aggatcccca gagccctgtg ccaacggagg cacctgcctg aggctatctc agggacaagg
      301 gacctgccag tgtgcccctg gatttctggg tgagacttgc cagttccctg acccctgctg
      361 ggacacccaa ctctgcgaga acggtggcag ctgtcaagcc ttgctcccca cagccccaag
      421 ctcccacagc cccacttctc cactgacccc ccacttctcc tgcacctgcc cctctggctt
      481 cactggtgat cgatgccaaa gccctctgga agagctctgt ccgccttctt tctgttccaa
      541 cgggggtcac tgctctgtcc aggtctcggg ccgcccacag tgttcctgcg agcccgggtg
      601 gacaggtgag cagtgccagc tccgagactt ctgctcagcc aacccctgtg ccaacggagg
      661 tgtgtgcttg gccacatacc cccagatcca gtgtcgttgt ccaaccggct tcgagggtca
      721 catctgtgaa cgcgacgtca atgaatgctt cctggagccc ggaccctgcc ctcggggcac
      781 ctcctgtcac aacaccttgg gctccttcca gtgcctctgc cctgtggggc aggaaggtcc
      841 ccagtgcaag ctcaggaagg gagcctgcct tcctggaacc tgtctcaatg gaggcacctg
      901 ccagctggtg ccagagggag acactacctt tcatctctgc ctctgtcccc caggtttcac
      961 agggctgaac tgtgagatga atccagatga ctgtgtcagg aaccagtgtc agaacggggc
     1021 cacctgccag gatgggctgg gcacctacac ctgcctctgc cccaagacgt ggaagggctg
     1081 ggactgctcc gaagacatag atgaatgtga agcccagggt ccgcctcgat gcagaaacgg
     1141 tggcacctgc cagaactcgg ctggtggctt tcactgtgtg tgtgtgagtg gctggggagg
     1201 cgagggctgt gacgagaacc tggatgactg tgcggccgcc acctgtgccc tgggatccac
     1261 ctgcatcgac cgtgtgggct ccttctcctg cctctgccca cctggacgca caggcctcct
     1321 gtgccacctg gaagacatgt gtttgaggca gccgtgccat gtgaatgccc agtgcagcac
     1381 caaccccctg acggggtcta ccctctgcat atgccagccg ggctactcgg gacccacctg
     1441 ccaccaagat ctggatgagt gtcaaatggc ccagcaagga cccagtccct gtgaacacgg
     1501 cggctcctgc atcaacaccc ctggctcctt caactgcctc tgcctgcctg gctacacggg
     1561 ctcccgctgc gaggctgacc acaatgagtg cctgtcgcag ccctgtcacc cgggcagcac
     1621 ctgcctggac ctgcttgcca ccttccagtg cctctgccca ccaggcctgg aagggaggct
     1681 ctgtgaagtg gagatcaatg agtgtgcctc taacccctgc ctcaaccaag ctgcctgtca
     1741 cgaccagctc aacggcttcc tgtgcctctg ccttcctgga ttcactggtg ccagatgcga
     1801 gaaagacatg gacgagtgca gcagcgcccc ctgtgccaat ggggggcact gccaagacca
     1861 gcctggagcc ttccactgcg agtgtctccc aggctttgaa gggccacgct gtgagactga
     1921 agcggatgaa tgtcggagtg acccctgccc cgtgggagcc agctgccttg atcttcccgg
     1981 ggcgttcctc tgcctctgcc ggcctggttt cacaggtcaa ctttgtgagg ttcccttgtg
     2041 tagccccatc ctgtgccaac ctggacagca atgccaagac caggaacaca gagccccctg
     2101 cctctgccct gacggaagtc ctggctgtgt tcctgctgag gacgactgcc cctgccacca
     2161 tggccattgc cagagatcct tgtgtgtgtg taacgagggc tggactggac cagagtgtga
     2221 gacagagctg ggcggctgcc tctccacacc ctgtgcccat ggggggacct gccacccaca
     2281 gccctctggc tacaactgta gctgccttgc aggctacacg gggctgacct gtagtgagga
     2341 gataacagct tgtcactcag ggccctgtct caatggtggc tcctgcagca tccatcctga
     2401 gggctactct tgcacctgcc ctccaagtca cacaggtccc cactgccaga ctgccgtgga
     2461 ccactgtgcg tctgcctcgt gtctcaacgg gggtacctgc atgagcaaac ctggcacttt
     2521 cttctgccac tgtgccactg gcttccaggg gctgcactgt gagaagaaga ttcaccccag
     2581 ctgtgcagac aacccctgca ggaacaaggc aacctgccaa gacacacctc gaggggcccg
     2641 ctgcctctgc agccctggct acacaggaag cagctgccag actctgatag acttgtgtgc
     2701 ccggaagccc tgtccacaca ctgcccgatg cctccagagt gggccctcct tccactgcct
     2761 gtgccaccag ggatggacag ggtctctctg tgacctccca ctgtcctgcc aggcggccgc
     2821 gatgagccaa ggtgtagaga tctccaacct gtgccagaat gggggcctct gtattgacac
     2881 gggctcctcc tatttctgtc gctgccctcc tggattcgag ggcaagttat gccaggatac
     2941 tgtgaacccc tgcacgtcca agccttgcct tcacggggct acctgtgtgc cccagcccaa
     3001 cggctatgtc tgccagtgtg ccccaggcta tgaaggacag aactgctcaa aagtacacga
     3061 cgcttgccag tccgggccgt gccacaacca tggaacctgt acccccaggc ctggaggctt
     3121 ccactgtgcc tgccctccag gttttgtggg gctgcgctgt gagggggatg tggacgagtg
     3181 tctcgaccgg ccctgccacc cctcgggcac tgcgtcctgc cattctttag ccaacgcctt
     3241 ctattgccag tgtctgcctg ggcacacagg ccagcggtgt gaagtggaga tggacctctg
     3301 ccagagccag ccctgctcca atggagggtc ctgtgaggtc acaacaggac cgccccctgg
     3361 cttcacctgc cgctgccccg agggttttga aggccccacc tgcagccgca aagcccctgc
     3421 ctgcggcaac catcattgcc acaacggagg cctatgtctg ccctccccta agccaggctc
     3481 cccacccctc tgtgcctgcc tcagtggctt cgggggccct gactgtctga cacctccagc
     3541 tccaccaggg tgcggtcctc cctccccctg catgcacaat ggtagctgca ctgagacccc
     3601 cgggttgggc aatcctggct ttcaatgcac ctgccctcct gactctccgg ggccccggtg
     3661 tcaaaggcca ggggcgaatg gatgtgaggg ccgaggtggc gatggagcct gtgatgctgg
     3721 ctgcagtggc ccaggagggg actgggatgg aggggactgt tccctggggg tcccagaccc
     3781 ctggaagggc tgtcccccgc attcccagtg ctggcttctc ttccgggatg ggcggtgcca
     3841 cccacagtgc gactctgagg agtgtctgtt tgatggctat gactgtgaga tccctccaac
     3901 ttgcacccca gcctacgacc agtactgccg agatcacttc cacaacgggc actgtgagaa
     3961 aggctgcaac aacgctcagt gtggctggga tgggggtgac tgcaggccag aaggggatga
     4021 ctcagagggg ggcccctccc tggccctgct ggtggtgctg agtcccccag ccttggatca
     4081 gcagctgctt gccctggctc gagtactgtc cctgactctg agggtcggtc tctgggtgag
     4141 gaaggacagt gaaggcagga acatggtgtt cccctatcct gggacccggg ccaaagagga
     4201 gctgagtgga actagagatt cctcttcgtg ggaaagacaa gcccctcaca ctcagacccc
     4261 gggcaaagag acagagtccc ttggtgcagg gtttgtggta gtgatgggag tggatttgtc
     4321 ccgctgtggt ccagagcatc ctgcgtcccg ctgtccccgg gactctgggc tcctgctgcg
     4381 tttccttgca gcaatggccg cagtgggagc tctggagccc ctgctgcctg gacccttgct
     4441 ggctgctcac cctcaagcag ggaccgggtc ccccgccacc cggcttccct ggcccattct
     4501 gtgttcgcca gtggtcgggg tgctcctcct ggcccttggg gctcttctcg tcctccagct
     4561 catccggcgc cggcggcggg aacacggggc cctgtggctg ccccctggtt tcattcgaag
     4621 gccacagaca cagcaggcac cccaccggcg gaggccccca ctgggcgagg acaacattgg
     4681 tctcaaggcg ctgaagccag aggcagaagt ggatgaggac ggagtggtca tgtgctcggg
     4741 ccctgaagag ggcgaggcag aaaaaacagc ctcagcctcc aggtgccagc tctggccact
     4801 gcgcagcggc tgtgaagggc tcccacaggc agtcatgctg acccctcctc aggagtgtga
     4861 atcagaactt ccagattcgg acacctgtgg acctgatggg gtgacacccc tgatgtctgc
     4921 cgtcttctgt gggggagtgc agtccaccac tgtacagaga ctgggactag gaaatcccga
     4981 accctgggaa ccactgctgg atagaggggc ctgcccccag gctcacactg tgggcactgg
     5041 agagacgccc ctgcacctag ctgcccgatt ctctcggcca actgctgccc gacgcctcct
     5101 ggaggctgga gccaacccca accagccaga ccgggctggg cgtaccccac ttcacactgc
     5161 agtagctgct gatgctcggg aggtttgcca gctcctattg gccagcagac agaccgctgt
     5221 agacgcgcgc acagacgacg ggactacacc tttgatgctg gctgccaggt tggccgtgga
     5281 ggacctggtt gaagaattga tcgcagcccg agcagatgta ggagccagag ataaaagggg
     5341 aaaaactgca ctgcactggg ccgctgcagt gaacaacgcc cgagctgccc gctgtctcct
     5401 ccagactgga gcggataaag atgcccagga cagtagggag cagacgccgc tgttcctggc
     5461 tgcgcgcgaa ggcgccgtgg aggtggcaca gctgctgctg gagatcgggg cagcgcgggg
     5521 gctgcgggac caggccgggc tggccccagc agatgtggcc cgccagcgta gtcattggga
     5581 cctgctgacg ctgctggagg gggcaggacc gatcacgcag gaggcccgtt cgcacgcacg
     5641 caacacgccg gggggcgggg ccgcgccgcg ctgccggacg ctgtctgccg gagcgcgccc
     5701 gcgcgggggc ggagcttgtc tgcaagctcg cacttggtcg gtggacttgg gagcgcgccg
     5761 aggggcggta tacgcgcgct gccggagccg atcaggaggc tctggaggcc cctccatgcg
     5821 cggccgcagg ctttccgcgg actcccgtgg acgacgcggg gctagagtat cacaggatga
     5881 ctggcctcgg gactgggtgg ccctggaagc ctgcggctct gcctgcagtg cgccgatccc
     5941 gcctcccagc cttaccccgt ccccagaacg cggatcccct caagtttcct ggggtcttcc
     6001 agtccaccaa gaggtcccct taaactcggg tggaaggaat cagaactagg caacttcgtg
     6061 gaaggaagga agtgacacga acgagtctgg aaggccccgg acttttaagg ccaagctaaa
     6121 cgttatgccc acttgtcttc cccatagagt atgaacagca atggcaagag ggtttaggat
     6181 gcccggatta gatatgccgt gctttttcct ggaaaatagg gcagctccaa gaggacagag
     6241 tggattttga gaatccctaa actgaaacca aaaactgtgg gcaaattggg tgtaaaatgt
     6301 ttcttatgta tggttttcca gaaggagcct ctgctatcta ctccccaaaa gtagctggca
     6361 aatatttatt gagcacctac tatgtgccag gtgttgtgta gatgatgaaa gctaaccagt
     6421 ggccagtcca gctgatgact ccttgccctc tctccgcctt ccccacaagg aaactggtac
     6481 agg
//
LOCUS       NM_178866               1530 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 1 (Igf1), transcript
            variant 2, mRNA.
ACCESSION   NM_178866
VERSION     NM_178866.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Xiong,J., Wang,Y., Wang,H., Luo,J., Chen,T., Sun,J., Xi,Q. and
            Zhang,Y.
  TITLE     GHRH-stimulated pituitary small extracellular vesicles inhibit
            hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p
  JOURNAL   J Nanobiotechnology 22 (1), 649 (2024)
   PUBMED   39438882
  REMARK    GeneRIF: GHRH-stimulated pituitary small extracellular vesicles
            inhibit hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   5  (bases 1 to 1530)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1530)
  AUTHORS   Nanto-Salonen,K. and Rosenfeld,R.G.
  TITLE     Insulin-like growth factor binding protein expression in the
            hypothyroid rat is age dependent
  JOURNAL   Endocrinology 131 (3), 1489-1496 (1992)
   PUBMED   1380443
REFERENCE   7  (bases 1 to 1530)
  AUTHORS   Hall,L.J., Kajimoto,Y., Bichell,D., Kim,S.W., James,P.L.,
            Counts,D., Nixon,L.J., Tobin,G. and Rotwein,P.
  TITLE     Functional analysis of the rat insulin-like growth factor I gene
            and identification of an IGF-I gene promoter
  JOURNAL   DNA Cell Biol 11 (4), 301-313 (1992)
   PUBMED   1605853
REFERENCE   8  (bases 1 to 1530)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 1530)
  AUTHORS   Nanto-Salonen,K., Glasscock,G.F. and Rosenfeld,R.G.
  TITLE     The effects of thyroid hormone on insulin-like growth factor (IGF)
            and IGF-binding protein (IGFBP) expression in the neonatal rat:
            prolonged high expression of IGFBP-2 in methimazole-induced
            congenital hypothyroidism
  JOURNAL   Endocrinology 129 (5), 2563-2570 (1991)
   PUBMED   1718729
REFERENCE   10 (bases 1 to 1530)
  AUTHORS   Kato,H., Okoshi,A., Miura,Y. and Noguchi,T.
  TITLE     A new cDNA clone relating to larger molecular species of rat
            insulin-like growth factor-I mRNA
  JOURNAL   Agric Biol Chem 54 (6), 1599-1601 (1990)
   PUBMED   1368571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC086374.1 and CB761687.1.
            
            On Dec 20, 2007 this sequence version replaced NM_178866.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences which include the absence of an
            alternate frame-shifting exon, compared to variant 3. These
            differences cause translation initiation from a distinct start
            codon and result in an isoform (b) with novel N- and C-termini,
            compared to isoform c. This isoform is also known as IIA.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086374.1, CO383788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-651               BC086374.1         1-651
            652-1391            BC086374.1         653-1392
            1392-1530           CB761687.1         291-429
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1530
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
     exon            1..46
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..445
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 2; somatomedin; IGF-I; Insulin-like growth factor
                     I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform b
                     preproprotein"
                     /protein_id="NP_849197.3"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
                     /translation="MSAPPIKIHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
                     ALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSA
                     RSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM"
     sig_peptide     32..127
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     proprotein      128..442
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform b
                     proprotein"
     mat_peptide     128..337
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform b"
     misc_feature    128..331
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    128..331
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    order(134..136,161..163,185..199)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(134..136,161..163,185..199)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(188..190,194..199,257..259)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(188..190,194..199,257..259)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(272..280,290..295)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(272..280,290..295)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     exon            47..203
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            204..385
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            386..1530
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgtgta aacgacccgg gacgtaccaa aatgagcgca cctccaataa agatacacat
       61 catgtcgtct tcacatctct tctacctggc actctgcttg ctcaccttta ccagctcggc
      121 cacagccgga ccagagaccc tttgcggggc tgagctggtg gacgctcttc agttcgtgtg
      181 tggaccaagg ggcttttact tcaacaagcc cacaggctat ggctccagca ttcggagggc
      241 accacagacg ggcattgtgg atgagtgttg cttccggagc tgtgatctga ggaggctgga
      301 gatgtactgt gctccgctga agcctacaaa gtcagctcgt tccatccggg cccagcgcca
      361 cactgacatg cccaagactc agaaggaagt acacttgaag aacacaagta gaggaagtgc
      421 aggaaacaag acctacagaa tgtaggagga gcctcccgag gaacagaaaa tgccacgtca
      481 ccgcaagatc ctttgctgct tgagcaacct gcaaaacatc ggaacacctg ccaaatatca
      541 ataatgagtt caataccatt tcagagatgg gcatttccct caatgaaata cacaagtaaa
      601 cattccgaca ttgtctttag gagtgtttgt taaaaaaaaa aaaaaaaaaa acaaaaacaa
      661 aaacaaaaaa aaaaagcttt gcaccttgca aaagtggtcc tggcgtgggt agattgctgt
      721 taatccttta tcaataacgt tctatagaga atatataaat atatatataa ttatatctcc
      781 tagtccctgc ctcttaagag ccgaaaatgc atgggtgttg tagacattcg gttgcactaa
      841 attcctctct gaattttggc tgctgaagcc gttcatttag caactgttta taggtggttg
      901 atgaatggtt ccttatctcc atttcttcct atgtagctta agccgcttcc ttcacagaat
      961 ctaataatct cgtctaggcc attagccctg ccctttctta acattcttgt atttgttgaa
     1021 tttggcctcc tcgaaagcaa tagcaactgg gtggcccacc caagttttaa cgcccctgat
     1081 tccatctatg gcatttgtac caaatataag ttggatgcat ttattttaga cacaaagctt
     1141 tattttttcg acatcgtgtt tcaagaaaaa aaacaaatag aataacaata actatgactt
     1201 tgaggccaat catttttagg tgtgtgtttg aagcatagaa cgtctcttaa actctcaatg
     1261 gttccttcaa atgatgagtt agtatgtaac gtaaatagca gtttctctct ctctctctct
     1321 ctttttattt tttccatata gagcactatg taaatttagc atatcaataa tacaggaact
     1381 atcaaacagt atgtaaactc cgttgttgtt gtttttagta caatggtgct attttgtagt
     1441 ttgttctatg aaagaatcta gtcaacacag agaaaggaga aagcaaagca aaaacaatga
     1501 aagcctggag cccaaaagga caaaattagg
//
LOCUS       NM_001105721            9407 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus notch receptor 1 (Notch1), mRNA.
ACCESSION   NM_001105721 XM_001078434 XM_342392
VERSION     NM_001105721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9407)
  AUTHORS   Wang,Y.C., Chen,R.F., Liu,K.F., Chen,W.Y., Lee,C.C. and Kuo,Y.R.
  TITLE     Adipose-derived stem cell modulate tolerogenic dendritic
            cell-induced T cell regulation is correlated with activation of
            Notch-NFkappaB signaling
  JOURNAL   Cytotherapy 26 (8), 890-898 (2024)
   PUBMED   38625070
  REMARK    GeneRIF: Adipose-derived stem cell modulate tolerogenic dendritic
            cell-induced T cell regulation is correlated with activation of
            Notch-NFkappaB signaling.
REFERENCE   2  (bases 1 to 9407)
  AUTHORS   Zhang,H., Gu,R., Luo,J., Zhong,C. and Pan,J.
  TITLE     Involvement of NOTCH1-mediated Microglia Activation in
            Neuromodulation of Chronic Prostatitis-related Pain
  JOURNAL   In Vivo 38 (2), 691-698 (2024)
   PUBMED   38418142
  REMARK    GeneRIF: Involvement of NOTCH1-mediated Microglia Activation in
            Neuromodulation of Chronic Prostatitis-related Pain.
REFERENCE   3  (bases 1 to 9407)
  AUTHORS   Li,Y., Ma,L., Deng,Y., Du,Z., Guo,B., Yue,J., Liu,X. and Zhang,Y.
  TITLE     The Notch1/Hes1 signaling pathway affects autophagy by adjusting
            DNA methyltransferases expression in a valproic acid-induced autism
            spectrum disorder model
  JOURNAL   Neuropharmacology 239, 109682 (2023)
   PUBMED   37543138
  REMARK    GeneRIF: The Notch1/Hes1 signaling pathway affects autophagy by
            adjusting DNA methyltransferases expression in a valproic
            acid-induced autism spectrum disorder model.
REFERENCE   4  (bases 1 to 9407)
  AUTHORS   Wang,P., Zhang,S., Hu,C., Ren,L. and Bi,J.
  TITLE     Regulatory role of melatonin in Notch1 signaling pathway in
            cerebral cortex of Abeta1-42-induced Alzheimer's disease rat model
  JOURNAL   Mol Biol Rep 50 (3), 2463-2469 (2023)
   PUBMED   36602704
  REMARK    GeneRIF: Regulatory role of melatonin in Notch1 signaling pathway
            in cerebral cortex of Abeta1-42-induced Alzheimer's disease rat
            model.
REFERENCE   5  (bases 1 to 9407)
  AUTHORS   Yang,C., Pan,J., Luo,X., Li,J. and Jiang,Z.
  TITLE     Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast
            proliferation by regulating the WWP2/Notch1 axis
  JOURNAL   Regen Med 17 (6), 375-388 (2022)
   PUBMED   35545948
  REMARK    GeneRIF: Hypoxia-induced mesenchymal stem cells inhibit corneal
            fibroblast proliferation by regulating the WWP2/Notch1 axis.
REFERENCE   6  (bases 1 to 9407)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   7  (bases 1 to 9407)
  AUTHORS   Conlon,R.A., Reaume,A.G. and Rossant,J.
  TITLE     Notch1 is required for the coordinate segmentation of somites
  JOURNAL   Development 121 (5), 1533-1545 (1995)
   PUBMED   7789282
REFERENCE   8  (bases 1 to 9407)
  AUTHORS   Lindsell,C.E., Shawber,C.J., Boulter,J. and Weinmaster,G.
  TITLE     Jagged: a mammalian ligand that activates Notch1
  JOURNAL   Cell 80 (6), 909-917 (1995)
   PUBMED   7697721
REFERENCE   9  (bases 1 to 9407)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     Notch2: a second mammalian Notch gene
  JOURNAL   Development 116 (4), 931-941 (1992)
   PUBMED   1295745
REFERENCE   10 (bases 1 to 9407)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     A homolog of Drosophila Notch expressed during mammalian
            development
  JOURNAL   Development 113 (1), 199-205 (1991)
   PUBMED   1764995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_342392.3, XM_001078434.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132263
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..9407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..9407
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="notch receptor 1"
                     /db_xref="GeneID:25496"
                     /db_xref="RGD:3187"
     exon            1..287
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    158..160
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="upstream in-frame stop codon"
     CDS             227..7822
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="neurogenic locus notch homolog protein 1; Notch
                     gene homolog 1; Drosophila Notch homolog 1 (controlling
                     the the ectodermal and neural cell fate in Drosophila);
                     notch 1"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 1
                     precursor"
                     /protein_id="NP_001099191.1"
                     /db_xref="GeneID:25496"
                     /db_xref="RGD:3187"
                     /translation="MPRLLAPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTE
                     ACVCSGAFVGQRCQDPSPCLSTPCKNAGTCYVVDHGGIVDYACSCPLGFSGPLCLTPL
                     ANACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFES
                     SYICGCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELP
                     YVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGV
                     NTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNSHGGYNCVCVNGWTGEDCSE
                     NIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPV
                     NGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCE
                     IDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGRCVDK
                     INEFLCQCPKGFSGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD
                     IDECDPDPCHYGLCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNY
                     YLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDEC
                     AGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCD
                     CAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
                     PCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCV
                     CPTGWQGQTCEIDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPN
                     PCHNGGSCTDGVNAAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCP
                     TGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPC
                     LHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGKCWQTNTQYHCECRSG
                     WTGFNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEEDKHYCHCQAGYTGSYCEDEV
                     DECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNT
                     YKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGE
                     RCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCRNGG
                     VCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSF
                     TGPECQFPASSPCVGSNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFTGGA
                     GRDIPPPQIEEACELPECQEDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSL
                     QCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSA
                     ECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDA
                     QGQQMIFPYYGREEELRKHPIKRSAVGWATTSLLPGTNGGRQRRELDPMDIHGSIVYL
                     EIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSETVEPPLPSQLHL
                     MYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGL
                     KPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAAD
                     LRVSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVI
                     SDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAA
                     VSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDD
                     LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHF
                     ANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTALGGTPTLSPTLCSP
                     NGYLGNLKSATQGKKARKPSTKGLACSSKEAKDLKARRKKSQDGKGCLLDSSSMLSPV
                     DSLESPHGYLSDVASPPLLPSPFQQSPSMPLSHLPGMPDTHLGISHLNVAAKPEMAAL
                     AGGSRLAFEPPPPRLSHLPVASSASTVLSTNGTGAMNFTVGAPASLNGQCEWLPRLQN
                     GMVPSQYNPLRPGVTPGTLSTQAAGLQHGMMGPIHSSLSTNTLSPIIYQGLPNTRLAT
                     QPHLVQTQQVQPQNLQIQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLG
                     PSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPPSQHSYSSSPVDNTPSHQLQV
                     PEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTSMPSQITHIPEAFK"
     sig_peptide     227..280
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     281..7819
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /product="Neurogenic locus notch homolog protein 1.
                     /id=PRO_0000007680"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3)"
     misc_feature    347..349
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    419..421
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    443..445
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    572..574
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    650..751
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    650..751
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    662..664
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    758..874
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    758..874
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(758..760,767..769,815..817)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(758..760,767..769,815..817)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    806..808
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    920..922
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q01705; O-linked
                     (GalNAc...) threonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    995..1105
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    995..1105
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(995..997,1004..1006,1046..1048)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(995..997,1004..1006,1046..1048)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1109..1222
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1109..1222
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1109..1111,1118..1120,1166..1168)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1109..1111,1118..1120,1166..1168)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1157..1159
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1229..1336
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1229..1336
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1229..1231,1238..1240,1280..1282)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1229..1231,1238..1240,1280..1282)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1247..1249
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1271..1273
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1358..1360
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1460..1576
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1460..1576
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1460..1462,1469..1471,1517..1519)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1460..1462,1469..1471,1517..1519)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1484..1489
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Interaction with DLL4.
                     /evidence=ECO:0000269|PubMed:25700513,
                     ECO:0007744|PDB:4XL1"
     misc_feature    1529..1531
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:25700513,
                     ECO:0007744|PDB:4XL1; propagated from UniProtKB/Swiss-Prot
                     (Q07008.3); glycosylation site"
     misc_feature    1568..1582
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Interaction with DLL4.
                     /evidence=ECO:0000269|PubMed:25700513,
                     ECO:0007744|PDB:4XL1"
     misc_feature    1580..1690
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1580..1690
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1580..1582,1589..1591,1631..1633)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1580..1582,1589..1591,1631..1633)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1598..1600
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:25700513; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1622..1624
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000269|PubMed:25700513,
                     ECO:0007744|PDB:4XL1; propagated from UniProtKB/Swiss-Prot
                     (Q07008.3); glycosylation site"
     misc_feature    1631..1633
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Interaction with DLL4.
                     /evidence=ECO:0000269|PubMed:25700513,
                     ECO:0007744|PDB:4XL1; propagated from UniProtKB/Swiss-Prot
                     (Q07008.3); other site"
     misc_feature    1694..1804
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1694..1804
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1694..1696,1703..1705,1745..1747)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1694..1696,1703..1705,1745..1747)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1712..1714
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000269|PubMed:25700513; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1808..1918
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1808..1918
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1808..1810,1817..1819,1859..1861)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1808..1810,1817..1819,1859..1861)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1826..1828
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    1922..2029
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    1922..2029
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(1922..1924,1931..1933,1970..1972)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(1922..1924,1931..1933,1970..1972)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2033..2143
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2033..2143
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2033..2035,2042..2044,2084..2086)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2033..2035,2042..2044,2084..2086)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2051..2053
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2075..2077
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2147..2251
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2147..2251
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2147..2149,2156..2158,2195..2197)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2147..2149,2156..2158,2195..2197)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2165..2167
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2258..2365
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2258..2365
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2258..2260,2267..2269,2309..2311)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2258..2260,2267..2269,2309..2311)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2300..2302
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2375..2476
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2375..2476
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2390..2392
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2489..2593
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2489..2593
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2501..2503
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2525..2527
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2576..2578
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2597..2707
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2597..2707
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2597..2599,2606..2608,2648..2650)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2597..2599,2606..2608,2648..2650)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2615..2617
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2639..2641
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2831..2941
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2831..2941
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2831..2833,2840..2842,2882..2884)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2831..2833,2840..2842,2882..2884)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2888..2890
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2924..2926
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    2945..3055
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    2945..3055
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(2945..2947,2954..2956,2996..2998)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(2945..2947,2954..2956,2996..2998)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    2987..2989
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3059..3169
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3059..3169
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(3059..3061,3068..3070,3110..3112)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(3059..3061,3068..3070,3110..3112)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    3077..3079
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3101..3103
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3188..3283
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3188..3283
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3215..3217
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3287..3397
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3287..3397
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(3287..3289,3296..3298,3338..3340)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(3287..3289,3296..3298,3338..3340)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    3305..3307
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3329..3331
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3419..3421
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3662..3766
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3662..3766
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3701..3703
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3761..3763
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3776..3883
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3776..3883
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3791..3793
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3815..3817
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    3887..4021
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    3887..4021
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(3887..3889,3896..3898,3962..3964)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(3887..3889,3896..3898,3962..3964)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    3947..3949
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4025..4141
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    4025..4141
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:238011"
     misc_feature    order(4025..4027,4034..4036,4082..4084)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(4025..4027,4034..4036,4082..4084)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    4043..4045
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Glc...) serine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4310..4312
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4361..4363
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (GlcNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4430..4432
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (Fuc...) threonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q01705; O-linked
                     (GalNAc...) threonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4550..4663
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Domain found in Notch and Lin-12; Region: NL;
                     smart00004"
                     /db_xref="CDD:197463"
     misc_feature    4550..4663
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Domain found in Notch and Lin-12; Region: NL;
                     smart00004"
                     /db_xref="CDD:197463"
     misc_feature    4571..4693
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: LNR 1"
     misc_feature    4685..4792
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    4685..4792
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    4691..4693
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    4694..4819
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: LNR 2"
     misc_feature    4799..4909
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    4799..4909
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="LNR domain; Region: Notch; pfam00066"
                     /db_xref="CDD:459658"
     misc_feature    4820..4939
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: LNR 3"
     misc_feature    4922..5089
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="NOTCH protein; Region: NOD; pfam06816"
                     /db_xref="CDD:462014"
     misc_feature    4922..5089
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="NOTCH protein; Region: NOD; pfam06816"
                     /db_xref="CDD:462014"
     misc_feature    4985..4987
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    5186..5191
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Cleavage, by furin-like protease.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); cleavage site"
     misc_feature    5213..5383
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="NOTCH protein; Region: NODP; pfam07684"
                     /db_xref="CDD:462229"
     misc_feature    5213..5383
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="NOTCH protein; Region: NODP; pfam07684"
                     /db_xref="CDD:462229"
     misc_feature    5354..5593
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in neurogenic locus notch homolog protein 1 (Notch1) and
                     similar proteins; Region: JMTM_Notch1; cd21702"
                     /db_xref="CDD:411985"
     misc_feature    5354..5593
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in neurogenic locus notch homolog protein 1 (Notch1) and
                     similar proteins; Region: JMTM_Notch1; cd21702"
                     /db_xref="CDD:411985"
     misc_feature    5354..5359
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Cleavage, by ADAM17.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); cleavage site"
     misc_feature    order(5357..5365,5372..5380,5411..5416,5420..5422,
                     5426..5479)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:411985"
     misc_feature    order(5357..5365,5372..5380,5411..5416,5420..5422,
                     5426..5479)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:411985"
     misc_feature    5369..5371
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P46531; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); glycosylation site"
     misc_feature    5378..5476
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Interaction with PSEN1.
                     /evidence=ECO:0000250|UniProtKB:P46531"
     misc_feature    5402..5464
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     transmembrane region"
     misc_feature    5534..5620
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    5777..5779
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q01705; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); phosphorylation site"
     misc_feature    order(5834..5836,5840..5842,5852..5857,5864..5872,
                     5915..5920,5930..5932,5939..5941,5969..5971,5975..5977,
                     5981..5983,5993..5998,6005..6013,6017..6022,6032..6034,
                     6041..6043,6068..6070,6074..6076,6080..6082,6092..6097,
                     6104..6112,6116..6121,6131..6133,6140..6142)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(5834..5836,5840..5842,5852..5857,5864..5872,
                     5915..5920,5930..5932,5939..5941,5969..5971,5975..5977,
                     5981..5983,5993..5998,6005..6013,6017..6022,6032..6034,
                     6041..6043,6068..6070,6074..6076,6080..6082,6092..6097,
                     6104..6112,6116..6121,6131..6133,6140..6142)
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    5834..5971
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5834..5971
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    <5906..6550
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <5906..6550
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    5975..6070
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5975..6070
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5975..6064
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: ANK 1"
     misc_feature    6035..6061
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: HIF1AN-binding. /evidence=ECO:0000250"
     misc_feature    6059..6061
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); hydroxylation site"
     misc_feature    6074..6169
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6074..6169
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6074..6166
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: ANK 2"
     misc_feature    6176..6271
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6176..6271
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6176..6265
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: ANK 3"
     misc_feature    6236..6262
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: HIF1AN-binding. /evidence=ECO:0000250"
     misc_feature    6260..6262
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q07008.3); hydroxylation site"
     misc_feature    6275..6469
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6275..6469
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    6275..6364
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: ANK 4"
     misc_feature    6374..6463
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: ANK 5"
     misc_feature    6647..6781
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    6662..>7804
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    6662..>7804
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    7370..7510
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    7544..7819
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07008.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            288..366
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..629
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..968
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1091
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1325
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1481
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1667
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1781
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1895
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2129
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2240
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2433
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2579
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2693
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2813
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2966
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3195
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3397
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3551
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3736
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3869
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4127
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4240
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4812
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..5214
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5363
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5580
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5668
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5834
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5835..6130
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6131..6278
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6279..6376
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6377..9407
                     /gene="Notch1"
                     /gene_synonym="NOTCH; TAN1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggggcgt ggggcgcagg gcgcgggtgc gagcgcagtg aaggaacgag cctgggtgcc
       61 tgtagtgccg gggagaccct gagagcccag cgccgcccac ccgccaggaa agagggcagc
      121 agcgggtgga cgcccgcggg accgcccgtg gtgcgcgtga acgtccgatc cccgccggcc
      181 accgcaagag gccgccgccc cggcagcggg cagctggcga gcaggcatgc cgcggctcct
      241 ggcgcccttg ctctgcctaa cgctgctgcc cgcgctcgcc gcaagaggct tgagatgctc
      301 ccagccaagt gggacctgcc tgaatggagg gaggtgcgaa gtggccaacg gcactgaagc
      361 ctgtgtctgc agcggagcgt tcgtgggcca gcgatgccag gaccccagcc cttgcctcag
      421 cacaccatgt aagaatgctg gaacgtgcta tgttgtggac catggcggca tcgtggacta
      481 tgcctgcagt tgccccctgg gtttctctgg gcccctctgc ctgacacctc tggccaatgc
      541 ctgcctggcc aacccctgcc gcaacggggg gacctgtgac ctgctcactc tcacagaata
      601 caagtgccgg tgcccgccag ggtggtcagg aaagtcatgt cagcaagccg acccctgtgc
      661 ctccaacccc tgtgccaatg gtggccagtg cctgcccttt gagtcttcat acatctgtgg
      721 ctgcccgccc ggcttccatg gccccacctg cagacaagat gttaacgagt gcagccagaa
      781 ccctgggttg tgccgtcatg gcggcacgtg ccacaatgag attggctcct atcgctgtgc
      841 ctgccgtgcc acccacactg gtccccactg cgagctgccc tacgtgccct gcagcccctc
      901 accctgccag aacggaggca cctgccgccc tacgggggac accacccacg agtgtgcctg
      961 cctgccaggc tttgctggac agaactgtga agaaaatgtg gatgactgcc caggaaacaa
     1021 ctgcaagaac gggggtgcct gtgtggacgg tgtgaatacc tacaattgcc gctgcccacc
     1081 ggagtggaca ggtcagtact gcacagagga tgtggacgag tgtcagctca tgcccaacgc
     1141 ctgccagaat ggcggaacct gccacaactc ccacggtggc tacaactgcg tgtgtgtcaa
     1201 tggctggact ggtgaggact gcagtgagaa cattgatgac tgtgccagtg ccgcctgttt
     1261 tcagggtgcc acctgccatg accgtgtggc ttccttctac tgcgagtgtc cacatgggcg
     1321 cacaggcctg ctgtgccacc tgaacgatgc gtgtatcagc aacccctgca acgagggctc
     1381 caactgcgac accaaccctg tcaacggcaa ggccatctgc acttgcccct cggggtacac
     1441 ggggccagcc tgcagccagg acgtggatga gtgcgctcta ggtgccaacc cgtgtgagca
     1501 cgcgggcaag tgcctcaaca cactgggctc tttcgagtgt cagtgtctac agggctacac
     1561 tgggccccgc tgtgagattg atgtcaacga gtgcatctcc aacccatgtc agaatgatgc
     1621 cacgtgcctg gaccagattg gggagtttca gtgtatatgt atgccaggtt atgagggtgt
     1681 atactgtgag atcaacacgg acgagtgtgc cagcagcccc tgtctacaca atggccgctg
     1741 cgtggacaag atcaacgagt tcctgtgtca gtgtcccaaa ggcttcagcg ggcacctgtg
     1801 ccagtatgac gtggatgagt gcgccagcac accatgcaag aacggcgcca agtgcctgga
     1861 tgggcccaac acctacacct gcgtgtgcac agaaggttac acggggaccc actgcgaggt
     1921 ggacattgac gagtgtgacc ctgacccctg tcactatggt ttgtgcaagg atggtgtggc
     1981 cacctttacc tgcctctgcc agccaggcta cacaggccat cactgtgaga ccaacattaa
     2041 tgagtgtcac agccagccgt gccgccatgg cggcacctgc caggaccgtg acaactacta
     2101 cctctgctta tgcctcaagg ggaccacagg acccaactgt gagatcaatc tggatgactg
     2161 tgcgagcaac ccctgtgact ctggcacgtg tctggacaag atcgatggct acgagtgtgc
     2221 gtgcgagcca ggctacacag ggagcatgtg taatgtcaac attgacgaat gtgcgggcag
     2281 cccctgccac aacgggggca cctgtgagga tggcatcgcc ggcttcactt gccgctgccc
     2341 cgagggctac cacgacccta cgtgcctgtc tgaggtcaac gagtgcaaca gtaacccctg
     2401 catccatgga gcttgccggg atggcctcaa tggatacaaa tgtgactgtg cccctgggtg
     2461 gagtgggaca aactgtgaca tcaacaacaa tgagtgtgag tccaaccctt gtgtcaacgg
     2521 tggcacctgc aaagacatga ccagtggcta cgtatgcacc tgccgagaag gcttcagtgg
     2581 ccctaactgc cagaccaaca ttaacgaatg tgcttccaac ccctgcctga accagggcac
     2641 ctgcattgat gatgtcgctg ggtacaaatg caactgccct ctgccctata caggagccac
     2701 atgtgaggtg gtgttggccc catgtgccac cagcccctgc aaaaacagtg gggtatgcaa
     2761 ggagtctgag gactatgaga gcttttcctg tgtctgtccc acaggctggc aaggtcaaac
     2821 ctgcgagatc gacatcaatg agtgtgtgaa aagcccgtgt cgccatggtg cctcttgcca
     2881 gaacaccaat ggcagctacc gctgcctctg ccaggctggc tacacgggtc gcaactgcga
     2941 gagtgacatc gatgactgcc gacccaaccc atgtcacaac gggggttcct gcactgacgg
     3001 ggtcaacgcg gccttctgcg actgcctgcc cggcttccag ggtgccttct gtgaggagga
     3061 catcaacgaa tgcgccagca atccatgcca aaatggcgcc aactgcactg actgcgtgga
     3121 cagctacacg tgcacctgcc ccacgggctt caatggcatc cattgcgaga acaacacacc
     3181 tgactgtacc gagagctcct gtttcaatgg tggcacctgt gtggatggta tcaactcctt
     3241 cacctgtctg tgcccacctg gcttcacggg cagctactgc cagtatgacg tcaatgagtg
     3301 tgactcacgg ccctgtctgc atggtggcac ctgccaagac agctatggta cctataagtg
     3361 tacctgccca cagggctaca ctggtctcaa ctgccagaac cttgtgcgct ggtgtgactc
     3421 agctccctgc aagaatggcg gcaagtgctg gcagaccaac acacagtacc actgcgagtg
     3481 ccgcagcggc tggactggct tcaactgcga cgtgctcagt gtgtcctgcg aggtggctgc
     3541 acagaagcga ggcatcgatg tcactctcct atgccagcac ggagggctct gtgtggatga
     3601 ggaagacaag cattactgcc actgccaggc aggatacacg ggcagctact gtgaggacga
     3661 ggtggacgag tgctcaccta atccctgcca gaacggagcc acctgcactg actatctcgg
     3721 tggcttttcc tgcaagtgtg tggctgggta ccatggctct aactgctctg aggagatcaa
     3781 cgagtgccta tcccaaccct gccagaatgg gggtacctgc attgatctga ccaacaccta
     3841 caagtgctcc tgccccaggg gcacacaggg tgtacactgt gagatcaacg tcgatgactg
     3901 ccatcctccc ctagaccctg cttcccgaag ccccaaatgc ttcaataatg gcacctgcgt
     3961 ggaccaggtg ggtggctata cctgcacctg cccgccaggc ttcgtcgggg agcggtgcga
     4021 gggcgatgtc aatgagtgtc tctccaaccc ctgtgaccca cgtggcaccc agaactgcgt
     4081 gcagcgtgtt aatgacttcc actgcgagtg ccgggctggc cacactggac gccgctgtga
     4141 gtcggtcatt aatggctgca ggggcaaacc atgcaggaat ggaggtgtct gtgctgtggc
     4201 ctccaacacc gcccgtggat tcatctgtag gtgccctgcg ggcttcgagg gtgccacttg
     4261 tgaaaatgac gcccgcactt gtggcagttt gcgctgcctc aacggtggta cgtgcatctc
     4321 aggcccacgc agtcccacct gcctatgcct gggctccttc actggccctg aatgccagtt
     4381 cccagccagc agcccctgtg tgggtagcaa cccctgctac aatcagggca cctgtgagcc
     4441 cacatccgag agccctttct accgctgtct atgccctgcc aaattcaacg ggctgctgtg
     4501 ccacatcctg gactacagct tcacaggtgg cgccgggcgc gacattcccc cgccacagat
     4561 tgaggaggcc tgcgaactgc ctgagtgcca ggaggatgca ggcaataagg tctgcaacct
     4621 tcagtgtaat aatcacgcgt gtggctggga cggcggcgac tgctccctca acttcaatga
     4681 cccttggaag aactgcactc agtccctgca gtgctggaag tattttagtg acggccactg
     4741 tgacagccag tgcaactcag ctggctgcct ttttgatggc ttcgactgcc agctcaccga
     4801 gggacagtgc aaccccctgt atgaccagta ctgcaaggac cacttcagtg atggccactg
     4861 cgaccagggc tgcaacagtg ccgagtgtga gtgggatgga ctggactgtg cagagcatgt
     4921 ccccgagcga ctggcagccg gcacactggt gctggtggtg ctgcttccgc ccgatcagct
     4981 acgcaacaac tccttccact tcctgcggga gctcagccac gtgctgcaca ccaacgtggt
     5041 cttcaagcgt gacgcgcagg gccagcagat gatcttcccc tactatggcc gcgaggaaga
     5101 gctacgcaag cacccgatca agcgttctgc agtgggctgg gccacaacgt cactgcttcc
     5161 tggcaccaat ggtgggcgcc agcgcaggga gctggacccc atggacatcc atggctccat
     5221 cgtctacctg gagatcgaca accggcagtg tgtacagtca tcctcgcaat gcttccagag
     5281 cgccaccgat gtggctgcct tcctaggtgc tcttgcctcc ctcggcagcc tcaatatccc
     5341 ctacaagatc gaagccgtaa agagtgagac ggtggagcct ccgctgccct cacagctgca
     5401 cctcatgtac gtggcggcag ctgccttcgt gctcctgttc tttgtgggct gtggggtgct
     5461 gctgtcccgc aagcgcaggc ggcagcatgg ccagctctgg ttccctgagg gtttcaaagt
     5521 gtcagaggcc agcaagaaga agcggagaga acccctcggc gaggactcag tcggcctcaa
     5581 gcccctgaag aacgcctcag atggtgccct gatggacgac aatcagaacg agtgggggga
     5641 cgaagacctg gagaccaaga agttccggtt tgaggaacca gtggttctcc ctgacctgga
     5701 tgatcagact gaccaccggc agtggaccca gcagcacctg gatgccgctg acctacgtgt
     5761 gtctgccatg gccccaacgc cgcctcaggg ggaggtagat gctgactgca tggacgtcaa
     5821 tgttcgagga ccagatggct tcactcccct aatgattgcc tcctgcagcg gagggggcct
     5881 ggagacaggc aacagtgagg aagaagaaga tgcacctgct gtcatctccg acttcatcta
     5941 tcagggtgcc agcttgcaca accagacgga ccgcacaggg gagactgccc tgcacctggc
     6001 tgcccgatac tctcgttcag atgctgccaa gcgcttgctg gaggccagcg cagatgccaa
     6061 catccaagac aacatggggc gtaccccatt acatgccgct gtttctgcag acgctcaggg
     6121 tgtcttccag atcctgctcc ggaacagagc cacagatctg gatgcccgaa tgcatgatgg
     6181 cacaacccct ctgatcctgg cggcacgcct ggccgtggaa ggcatgctag aggacctcat
     6241 caactctcac gctgatgtca atgctgtgga tgacctaggc aagtcagctc tgcactgggc
     6301 agccgctgtg aacaatgtgg acgctgctgt tgtgctcctg aagaacggag ccaacaaaga
     6361 catgcagaac aacaaggagg agactcccct gttcctggcc gcccgtgagg gcagctatga
     6421 gactgccaaa gtgttgctgg accactttgc caaccgggac atcacggatc acatggaccg
     6481 attgccacgg gacattgcac aggagcgcat gcaccacgat atcgtgcggc ttttggatga
     6541 atacaacctg gtgcgcagcc cacagctgca tggcactgcc ttgggtggca cacccactct
     6601 gtctcccaca ctctgctcgc ccaacggcta cctgggcaac ctcaagtctg ccacacaggg
     6661 caagaaggcc cgaaagccca gcaccaaagg gctggcttgc agtagcaagg aagctaagga
     6721 cctcaaggcc cggaggaaga agtcccagga tggcaagggc tgcctgttgg acagctcaag
     6781 catgctgtca cccgtggact ccctcgagtc accccatggc tacttgtcag atgtggcctc
     6841 accacccctc cttccctccc cgttccagca gtctccatcc atgcctctca gccacctgcc
     6901 aggtatgcct gacacccacc tgggcatcag ccacttgaat gtggcagcca agcccgagat
     6961 ggcagctctg gccggaggca gccggttggc ctttgagcca cccccaccac gcctctccca
     7021 cctgcctgta gcctccagtg ccagcacagt gctgagtacc aatggcacag gggctatgaa
     7081 tttcaccgtg ggtgcaccgg caagcttgaa tggccagtgt gagtggcttc cccggctcca
     7141 gaatggcatg gtgcccagcc agtacaaccc gctaaggcca ggtgtgactc cgggcacact
     7201 aagcacacag gcagctggcc tccagcatgg catgatgggc ccgatacaca gcagcctctc
     7261 caccaatacc ttgtccccga ttatctacca gggcctgccc aacacaaggc tggccacaca
     7321 gccccacctg gtgcagaccc agcaggtgca gccacagaac ttacaaatcc agcctcagaa
     7381 cctgcagcca ccatcgcagc cacacctcag tgtgagctca gcagccaatg ggcacctggg
     7441 tcggagcttc ctgagcgggg agcccagcca ggcagacgta cagccgctgg gccccagcag
     7501 tctgcctgtg cacaccattc tgccccagga aagccaggct ctgccgacat cactgccatc
     7561 ctccatggtc ccacccatga ccactaccca gttcctgacc cctccttctc agcacagcta
     7621 ctcatcctca cctgtggaca acacccccag ccaccagctg caggtgccag agcacccctt
     7681 cctcacccca tcccctgagt cccctgacca gtggtccagc tcctccccgc attccaacat
     7741 ctctgattgg tccgagggca tctctagccc gcccacgagc atgccgtccc agatcaccca
     7801 cattccagag gcatttaagt aaacagagat gtgggatgaa ggaccccagc ttccgttccc
     7861 aagctctgtt gggagtcctt tccagtgctc caggatgctg gggcgaccaa aggagccttt
     7921 taaaaaaaaa tgtttttata caaaataaga ggacaagaat ttccattttt ttttttagta
     7981 tttatttatg tacttttatt ttccacagaa acactgcctt tttatttata tgtattgttt
     8041 tctatggcac taggggaaaa catctgttcc aagaaaataa actagttctg agagcctcga
     8101 ttttcctggt cagggtgaag ttccctgtgt gtttgtaaaa tacgaacaag gattcatgat
     8161 ttgtaaatgc cgtttattta ttgattgctt ctttccaaaa tcgtcgagaa agaaagaaag
     8221 aaaaagaaag aaagaaagaa agaaaggaaa gaaagaaaga aaggcatgct aggagaaagg
     8281 aggaggaggc tggaaacttc ctcgccagat ttccccctcc ccagatgcct gctaccccac
     8341 tcactgcccc tcctcccagt gtcacctggg atttgcagat gtgtttagaa acaggccaag
     8401 accttgaacc tcgggtacat ggattagttt tgtatctaaa acaggaaaca agtaaaatga
     8461 tgtggtttgt acattttctg taaccaccgc atgggcttgg agaagtgtcc tcggtgtgtg
     8521 tggagtgttc tacccagtac caggtatgaa tctgcaggct tcagtgttct gtactagtgt
     8581 ttatggccct tgggagtact actcccctgc cctgccctgc cctgccctgc cctgccctgc
     8641 ccaactgtcc ccttcctgac atcttgagcc agtaagccaa gtggggtgtg gtgcctcctg
     8701 gagaatgaca ctgcctggac tgttccgtgc gtcacccctg aacagcatca tccaaattca
     8761 actgaggatg gactgtccct gcctgggcct gggctcctga catccgactg ccaaagggct
     8821 ccaatgtgca ctgtgaactc accagagcag cctacattga gacctcaaga agatataagc
     8881 tgtgtggcct ctgatccccc aactggcctg ggtggggacg tgccttgagt gtgctggaat
     8941 gtgggcggag cctgcctctg ggccacccct cctggttcag ggcggtgctc acagcagatt
     9001 tttgcagtat caagtatacg cctgtggcag aataagtatc tgtaaataca tgtttaaagg
     9061 tggattttgt ttaagaaatc taaaggaaca agtctgtccc gtgtcaagct gatgaggaat
     9121 gtcagaccat ggctcagctc ggtgtgaccc aggccttgtg acctgacagt agctcctaag
     9181 agcacaaccc aggatggccc atctgctgtc caccaagccc tttcccagcc actgtgtgcg
     9241 gggagggggg ctttcggggg cagctgccta cctcctcagg gcagctcctc ctggcctttt
     9301 gggaagcagt gtctgcgcta tacctaatag atatgaccag acacatccta agatgttgat
     9361 tcttactgtg ttttattaaa aaaaaatgta gtttacagaa aaaagaa
//
LOCUS       NM_001082477            1582 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 1 (Igf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001082477
VERSION     NM_001082477.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Xiong,J., Wang,Y., Wang,H., Luo,J., Chen,T., Sun,J., Xi,Q. and
            Zhang,Y.
  TITLE     GHRH-stimulated pituitary small extracellular vesicles inhibit
            hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p
  JOURNAL   J Nanobiotechnology 22 (1), 649 (2024)
   PUBMED   39438882
  REMARK    GeneRIF: GHRH-stimulated pituitary small extracellular vesicles
            inhibit hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   3  (bases 1 to 1582)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1582)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   5  (bases 1 to 1582)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1582)
  AUTHORS   Nanto-Salonen,K. and Rosenfeld,R.G.
  TITLE     Insulin-like growth factor binding protein expression in the
            hypothyroid rat is age dependent
  JOURNAL   Endocrinology 131 (3), 1489-1496 (1992)
   PUBMED   1380443
REFERENCE   7  (bases 1 to 1582)
  AUTHORS   Hall,L.J., Kajimoto,Y., Bichell,D., Kim,S.W., James,P.L.,
            Counts,D., Nixon,L.J., Tobin,G. and Rotwein,P.
  TITLE     Functional analysis of the rat insulin-like growth factor I gene
            and identification of an IGF-I gene promoter
  JOURNAL   DNA Cell Biol 11 (4), 301-313 (1992)
   PUBMED   1605853
REFERENCE   8  (bases 1 to 1582)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 1582)
  AUTHORS   Nanto-Salonen,K., Glasscock,G.F. and Rosenfeld,R.G.
  TITLE     The effects of thyroid hormone on insulin-like growth factor (IGF)
            and IGF-binding protein (IGFBP) expression in the neonatal rat:
            prolonged high expression of IGFBP-2 in methimazole-induced
            congenital hypothyroidism
  JOURNAL   Endocrinology 129 (5), 2563-2570 (1991)
   PUBMED   1718729
REFERENCE   10 (bases 1 to 1582)
  AUTHORS   Kato,H., Okoshi,A., Miura,Y. and Noguchi,T.
  TITLE     A new cDNA clone relating to larger molecular species of rat
            insulin-like growth factor-I mRNA
  JOURNAL   Agric Biol Chem 54 (6), 1599-1601 (1990)
   PUBMED   1368571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M17593.1, BC086374.1, M15480.1 and CB761687.1.
            
            On Dec 20, 2007 this sequence version replaced NM_001082477.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and 5'
            coding region, compared to variant 3. These differences cause
            translation initiation from a distinct start codon and result in an
            isoform (a) with a novel C-terminus, compared to isoform c. This
            isoform is also known as IIC.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ093477.1, M15480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                M17593.1           241-304
            65-319              BC086374.1         65-319
            320-658             M15480.1           364-702
            659-703             BC086374.1         607-651
            704-1443            BC086374.1         653-1392
            1444-1582           CB761687.1         291-429
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1582
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
     exon            1..46
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..463
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 1; somatomedin; IGF-I; Insulin-like growth factor
                     I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform a
                     preproprotein"
                     /protein_id="NP_001075946.2"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
                     /translation="MSAPPIKIHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
                     ALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSA
                     RSIRAQRHTDMPKTQKSQPLSTHKKRKLQRRRKGSTLEEHK"
     sig_peptide     32..127
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     proprotein      128..460
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform a
                     proprotein"
     mat_peptide     128..337
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform a"
     misc_feature    128..331
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    128..331
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    order(134..136,161..163,185..199)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(134..136,161..163,185..199)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(188..190,194..199,257..259)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(188..190,194..199,257..259)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(272..280,290..295)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(272..280,290..295)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     exon            47..203
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            204..385
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            386..437
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            438..1582
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgtgta aacgacccgg gacgtaccaa aatgagcgca cctccaataa agatacacat
       61 catgtcgtct tcacatctct tctacctggc actctgcttg ctcaccttta ccagctcggc
      121 cacagccgga ccagagaccc tttgcggggc tgagctggtg gacgctcttc agttcgtgtg
      181 tggaccaagg ggcttttact tcaacaagcc cacaggctat ggctccagca ttcggagggc
      241 accacagacg ggcattgtgg atgagtgttg cttccggagc tgtgatctga ggaggctgga
      301 gatgtactgt gctccgctga agcctacaaa gtcagctcgt tccatccggg cccagcgcca
      361 cactgacatg cccaagactc agaagtccca gcccctatcg acacacaaga aaaggaagct
      421 gcaaaggaga aggaaaggaa gtacacttga agaacacaag tagaggaagt gcaggaaaca
      481 agacctacag aatgtaggag gagcctcccg aggaacagaa aatgccacgt caccgcaaga
      541 tcctttgctg cttgagcaac ctgcaaaaca tcggaacacc tgccaaatat caataatgag
      601 ttcaatacca tttcagagat gggcatttcc ctcaatgaaa tacacaagta aacattccga
      661 cattgtcttt aggagtgttt gttaaaaaaa aaaaaaaaaa aaacaaaaac aaaaacaaaa
      721 aaaaaaagct ttgcaccttg caaaagtggt cctggcgtgg gtagattgct gttaatcctt
      781 tatcaataac gttctataga gaatatataa atatatatat aattatatct cctagtccct
      841 gcctcttaag agccgaaaat gcatgggtgt tgtagacatt cggttgcact aaattcctct
      901 ctgaattttg gctgctgaag ccgttcattt agcaactgtt tataggtggt tgatgaatgg
      961 ttccttatct ccatttcttc ctatgtagct taagccgctt ccttcacaga atctaataat
     1021 ctcgtctagg ccattagccc tgccctttct taacattctt gtatttgttg aatttggcct
     1081 cctcgaaagc aatagcaact gggtggccca cccaagtttt aacgcccctg attccatcta
     1141 tggcatttgt accaaatata agttggatgc atttatttta gacacaaagc tttatttttt
     1201 cgacatcgtg tttcaagaaa aaaaacaaat agaataacaa taactatgac tttgaggcca
     1261 atcattttta ggtgtgtgtt tgaagcatag aacgtctctt aaactctcaa tggttccttc
     1321 aaatgatgag ttagtatgta acgtaaatag cagtttctct ctctctctct ctctttttat
     1381 tttttccata tagagcacta tgtaaattta gcatatcaat aatacaggaa ctatcaaaca
     1441 gtatgtaaac tccgttgttg ttgtttttag tacaatggtg ctattttgta gtttgttcta
     1501 tgaaagaatc tagtcaacac agagaaagga gaaagcaaag caaaaacaat gaaagcctgg
     1561 agcccaaaag gacaaaatta gg
//
LOCUS       NM_001423000            4504 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus sarcosine dehydrogenase (Sardh), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001423000 XM_006233732
VERSION     NM_001423000.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4504)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 4504)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   3  (bases 1 to 4504)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 4504)
  AUTHORS   Bergeron,F., Otto,A., Blache,P., Day,R., Denoroy,L., Brandsch,R.
            and Bataille,D.
  TITLE     Molecular cloning and tissue distribution of rat sarcosine
            dehydrogenase
  JOURNAL   Eur J Biochem 257 (3), 556-561 (1998)
   PUBMED   9839943
REFERENCE   5  (bases 1 to 4504)
  AUTHORS   Porter,D.H., Cook,R.J. and Wagner,C.
  TITLE     Enzymatic properties of dimethylglycine dehydrogenase and sarcosine
            dehydrogenase from rat liver
  JOURNAL   Arch Biochem Biophys 243 (2), 396-407 (1985)
   PUBMED   2417560
REFERENCE   6  (bases 1 to 4504)
  AUTHORS   Cook,R.J., Misono,K.S. and Wagner,C.
  TITLE     The amino acid sequences of the flavin-peptides of dimethylglycine
            dehydrogenase and sarcosine dehydrogenase from rat liver
            mitochondria
  JOURNAL   J Biol Chem 260 (24), 12998-13002 (1985)
   PUBMED   4055729
REFERENCE   7  (bases 1 to 4504)
  AUTHORS   Wittwer,A.J. and Wagner,C.
  TITLE     Identification of the folate-binding proteins of rat liver
            mitochondria as dimethylglycine dehydrogenase and sarcosine
            dehydrogenase. Flavoprotein nature and enzymatic properties of the
            purified proteins
  JOURNAL   J Biol Chem 256 (8), 4109-4115 (1981)
   PUBMED   6163778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 29, 2023 this sequence version replaced XM_006233732.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.12981.1,
                                           SRR26643429.10874.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000003.1  30971664-30972137   c
            475-517             JAXUCZ010000003.1  30971525-30971567   c
            518-872             JAXUCZ010000003.1  30968824-30969178   c
            873-1051            JAXUCZ010000003.1  30967389-30967567   c
            1052-1231           JAXUCZ010000003.1  30966172-30966351   c
            1232-1355           JAXUCZ010000003.1  30962700-30962823   c
            1356-1456           JAXUCZ010000003.1  30962452-30962552   c
            1457-1561           JAXUCZ010000003.1  30959047-30959151   c
            1562-1691           JAXUCZ010000003.1  30957866-30957995   c
            1692-1778           JAXUCZ010000003.1  30954163-30954249   c
            1779-1869           JAXUCZ010000003.1  30953836-30953926   c
            1870-2011           JAXUCZ010000003.1  30951736-30951877   c
            2012-2095           JAXUCZ010000003.1  30949484-30949567   c
            2096-2209           JAXUCZ010000003.1  30947283-30947396   c
            2210-2348           JAXUCZ010000003.1  30942955-30943093   c
            2349-2462           JAXUCZ010000003.1  30941162-30941275   c
            2463-2610           JAXUCZ010000003.1  30936272-30936419   c
            2611-2704           JAXUCZ010000003.1  30932290-30932383   c
            2705-2867           JAXUCZ010000003.1  30917468-30917630   c
            2868-3036           JAXUCZ010000003.1  30916574-30916742   c
            3037-3172           JAXUCZ010000003.1  30911991-30912126   c
            3173-4504           JAXUCZ010000003.1  30908621-30909952   c
FEATURES             Location/Qualifiers
     source          1..4504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..4504
                     /gene="Sardh"
                     /note="sarcosine dehydrogenase"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
     exon            1..474
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            475..517
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            518..872
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    530..532
                     /gene="Sardh"
                     /note="upstream in-frame stop codon"
     CDS             539..3298
                     /gene="Sardh"
                     /EC_number="1.5.8.3"
                     /codon_start=1
                     /product="sarcosine dehydrogenase, mitochondrial"
                     /protein_id="NP_001409929.1"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
                     /translation="MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQC
                     TLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERL
                     TSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQ
                     QRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTC
                     TTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWA
                     SSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEA
                     NPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHK
                     PLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSL
                     TDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWER
                     PGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACR
                     TAAAVFNMSYFGKFYLLGADARKAADWLFSADVNRPPGSTVYTCMLNQRGGTESDLTV
                     SCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLG
                     MLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHV
                     PQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAF
                     TCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRA
                     DFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKR
                     VKGIY"
     transit_peptide 539..604
                     /gene="Sardh"
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q64380.2)"
     mat_peptide     605..3295
                     /gene="Sardh"
                     /product="Sarcosine dehydrogenase, mitochondrial.
                     /id=PRO_0000010772"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64380.2)"
     misc_feature    737..1873
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    737..1873
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    1058..1060
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    1829..1996
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1829..1996
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1979..3289
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1979..3289
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    2216..2218
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2864..2866
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2870..2872
                     /gene="Sardh"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UL12; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); phosphorylation site"
     misc_feature    2945..2947
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    3191..3193
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    3251..3253
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     exon            873..1051
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1231
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1355
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1456
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1561
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1691
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1778
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1869
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2011
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2095
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2209
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2348
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2462
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2610
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2704
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2867
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3036
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3172
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..4504
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtcctga cagccccttc atgggcaggt tggtcgccag ctgggacctc cctcttcttc
       61 tggttgaagg accatggact agatgggaag gccatggata aatgtggggg tgtaggaggg
      121 ggctccttta tgggagggct ctgcacagtg ccttcccctc ttgggttccc ttctaccccg
      181 ttgctgtctt agaaaacagc cccgtgtctg aggcctcagg cctgtgactg agctctcatt
      241 ccctgtgtcc tgtgccctgg tccttgggaa gctgagggag agagctgcag aggccagagg
      301 gcaggttaat gaagcatctg ctctgaagga ggggcacgct gggggcctgg ctgccccatc
      361 ccccacccct gccctgacta gctgggctgg cagagaagga gcacgtggca ggtcctccag
      421 ccagcagcat tggccttggg cacagtttgg agaggaagga ggttcctctg gcaggaatct
      481 cccaggagct tctggaaaat ctaggacgaa gactaaggta caggagccct aagtccccat
      541 ggcttcactg agccgggtcc tccgtgtagc tgccacctgt cctcgaggga gatctgctcg
      601 caacctgggg ctacagcccc tagccaggga ggccaggccc accactgaga agagtgttcc
      661 ataccagtgc accctgaagg aggaggccca aggtgcctct gtggtgcccc aaggaccaag
      721 ccagcccctg cctagcacag ccaatgttgt ggtcattggt gggggcagtt tgggctgcca
      781 gactctgtac cacttggcca agctgggtgt aggtggagtt gtgctgctgg agagagagcg
      841 actgacctct gggaccacct ggcacacagc aggcctactg tggcagctgc ggcccagcga
      901 tgtggaagta gagcttctgg ctcacacacg gcaagtggtg agccatgatc tggaagagga
      961 gactgggctt cacacaggct ggatccagaa tggtggcctc ttcatcgcct ccaaccagca
     1021 gcgcctggat gaatacaaga ggctcatgtc gttgggcaag gcctacggta tagaatccca
     1081 tgtgctgagc cctgcagaga ccaaggatct gtatccgctg atgaatgtgg acgacctcta
     1141 tgggaccctg tatgtgcctc gggatggtac catggacccg gctggcacct gcactaccct
     1201 caccagagca gcagtggcta ggggagctca ggtcattgaa aactgtgcag tgactggcat
     1261 ccgtgtgcgg acagacgact ttggagtgcg gcgggtgaca gctgtggaga ctcaacatgg
     1321 ctccatccag acaccctgcg tggtcaactg tgcaggggtg tgggcgagct ccgtgggccg
     1381 gatggctgga gtgaaggtcc cgctggtggc catgcaccat gcctacgttg tcactgagcg
     1441 cattgagggg atccagaaca tgcccaatgt ccgggatcat gatgcttctg tctacctccg
     1501 cctgcagggg gatgccttgt ctgtgggtgg ctatgaggcc aaccccatct tttgggatga
     1561 ggtgtcagac aaatttgcct ttggcctctt tgacctggac tgggatgtgt tcactcagca
     1621 cattgaaggt gccattaacc gtgtccccgt gttggagaaa acggggatca agtccactgt
     1681 ctgtggccct gaatccttca cacccgacca taagcccctg atgggggagg ctcctgagct
     1741 ccgaggcttc ttccttggct gtggcttcaa cagtgcaggc atgatgttgg gtggtggctg
     1801 tggacaggag ctggcccatt ggattgtgca tgggcgccca gagaaggaca tgtacagcta
     1861 tgacatcagg cgtttccacc actcgctcac ggaccaccca cgctggatcc gagagcgcag
     1921 ccacgagtcc tatgccaaga actactcggt tgtctttcct cacgatgagc ccctggcggg
     1981 ccgcaacatg aggagggacc ctctgcacga ggagctgctt ggacaaggct gtgtgtttca
     2041 agaacgacag ggctgggaac ggccaggatg gttcaacccc caagaaacag ctcaggtcct
     2101 agactacgac tactatgggg cctacggaca ccaggcacac aaggactacg cctacagcag
     2161 gctgctgggc gatgaatata ccttcgactt cccaccccac cactgcgtga tccagaagga
     2221 atgtctggcc tgcagaacgg ctgccgccgt gttcaacatg tcttacttcg ggaagttcta
     2281 ccttctgggg gcagacgcca ggaaggctgc agactggctc ttctcagcag atgtcaaccg
     2341 acccccaggc tccacggtgt acacatgcat gctgaaccaa cggggaggca ccgagagcga
     2401 cctgactgtt agctgcctgg cccctggtgc ccaggccagt cccctggccc ctgcctttga
     2461 aggggatggc tactacctag ccgtaggtgg ggctgtggcc caacataact ggtcccacat
     2521 aaacacggtg ctgcaggatc aggagttccg gtgccagctt atggattgtt ctgaagatct
     2581 gggcatgctc agtatccagg gcccagccag ccgtgacatt ctccaggatg tgcttgatgc
     2641 tgacctgagc aatgaagcct tccccttctc cacccaccag ctggtgagag ctgctggaca
     2701 cctggtccga gccatccggc tatcctttgt cggggagctg ggatgggagc tgcatgtgcc
     2761 ccaagcgtcc tgcttgcctg tgtaccgggc tgtgatggct gcaggggcga agcacggcct
     2821 agtcaatgca ggctaccgtg ccatcgactc cctgagcatt gagaaaggct atcggcactg
     2881 gcatgcagac ctgaggtccg atgacagccc cctggaggca gggttggcct tcacctgcaa
     2941 gctcaagacc tcagtgccct tcctaggccg agaggccctg gagaagcagc gtgccacagg
     3001 cctccgacga cgcctggtgt gcctcactgt ggaagaggag gttcctatgt tcggcctaga
     3061 ggccatctgg agaaatggcc aagtggtggg ccatgtccgg agagctgact ttggattcac
     3121 cgtgaacaag accatcgcct atggctacat ccgagacccc agtggagggc cagtctctct
     3181 ggactttgtg aagaatgggg actatgcctt ggagagaatg ggggtcacct atgctgccca
     3241 ggttcacctg aagtctccct ttgatcctga caacaagcgg gtgaagggaa tctattgatg
     3301 ggctgcaggg tggaggctac agctgctcag gcccctggaa actgccacac ttcccatacg
     3361 gcctgtggac tcctatactg tacaaacagc cctgtgtcct gagacccaag ataagggcaa
     3421 aacacagact tcccaccctg agcctccatc tggtcctgct aactgccaca gctcctaacc
     3481 agtaccacat ggaccactat gttcctcctg ctcacagacc acacagtggt ctccaatcca
     3541 ctctagccct cccaaaatgc accctgcaga tgtctgggct caaggtccct gtgtatggtt
     3601 aacccaagat agaagccata aagcaagcag gcatccagtc tgtccctcac ttggctgact
     3661 gcagtgggta gctggagtgt ctgaagggta gtggattggg agagtgagca gggattgatg
     3721 agtaatgtct gccatgggta taggatggag gacacagaga caggtgctgg actggtacag
     3781 tccttcttcg gaatggttgc cttttagacc agagagaaga aggataagca ggctcttgcc
     3841 cctagccttc cagctctgca ggagagaaag ccttctgaga gtcaccaacc agtgacacag
     3901 aaggcatgtg gcatgggatt tggatcagga acctcactta caaagaagtg tcatactctg
     3961 cctcagtttc ccctcaagcc attgctcatg ggtctggaga caccaagctt tcactcgtgc
     4021 ataacccagc tgcagtgtat gtttccaagg actttttatt tctgtcacag atgcatggct
     4081 tcctgatcaa gctctagtga ggggctgctc cagttctgct ttgtgagata gagtggcctc
     4141 ttctcccacc ctgtgtaacc atccacatat gtcctcatat caggggcacc ctgcctctcc
     4201 ttcctggggt gaacagccat cacttttctg tagacccaac cttcttcctc tgtctcacgc
     4261 cctgactgag aaatcgggct gctgtagctc cccaaacaaa gatcaccgtg tagccttatg
     4321 tgccttgtag tctaggagag aaggaggcca ttgcagtatg gagttgggtg tcttaaaccc
     4381 aaagaagtca gcagaaggga gatgtgggca caattgtcct gggtgggctc tgaatcttca
     4441 tagattcaca caccacacac tgtgccggaa aaaggtcaag ttaataaaat tttacgaaac
     4501 cgtt
//
LOCUS       NM_001082478            1879 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 1 (Igf1), transcript
            variant 3, mRNA.
ACCESSION   NM_001082478
VERSION     NM_001082478.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Xiong,J., Wang,Y., Wang,H., Luo,J., Chen,T., Sun,J., Xi,Q. and
            Zhang,Y.
  TITLE     GHRH-stimulated pituitary small extracellular vesicles inhibit
            hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p
  JOURNAL   J Nanobiotechnology 22 (1), 649 (2024)
   PUBMED   39438882
  REMARK    GeneRIF: GHRH-stimulated pituitary small extracellular vesicles
            inhibit hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Nanto-Salonen,K. and Rosenfeld,R.G.
  TITLE     Insulin-like growth factor binding protein expression in the
            hypothyroid rat is age dependent
  JOURNAL   Endocrinology 131 (3), 1489-1496 (1992)
   PUBMED   1380443
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Hall,L.J., Kajimoto,Y., Bichell,D., Kim,S.W., James,P.L.,
            Counts,D., Nixon,L.J., Tobin,G. and Rotwein,P.
  TITLE     Functional analysis of the rat insulin-like growth factor I gene
            and identification of an IGF-I gene promoter
  JOURNAL   DNA Cell Biol 11 (4), 301-313 (1992)
   PUBMED   1605853
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Nanto-Salonen,K., Glasscock,G.F. and Rosenfeld,R.G.
  TITLE     The effects of thyroid hormone on insulin-like growth factor (IGF)
            and IGF-binding protein (IGFBP) expression in the neonatal rat:
            prolonged high expression of IGFBP-2 in methimazole-induced
            congenital hypothyroidism
  JOURNAL   Endocrinology 129 (5), 2563-2570 (1991)
   PUBMED   1718729
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Kato,H., Okoshi,A., Miura,Y. and Noguchi,T.
  TITLE     A new cDNA clone relating to larger molecular species of rat
            insulin-like growth factor-I mRNA
  JOURNAL   Agric Biol Chem 54 (6), 1599-1601 (1990)
   PUBMED   1368571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB751206.1, BC086374.1, M15480.1 and CB761687.1.
            
            Transcript Variant: This variant (3) represents the longest variant
            and encodes isoform c. This isoform is also known as IB.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06107.1, FQ210560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               CB751206.1         48-390
            344-682             BC086374.1         47-385
            683-734             M15480.1           430-481
            735-1000            BC086374.1         386-651
            1001-1740           BC086374.1         653-1392
            1741-1879           CB761687.1         291-429
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1879
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
     exon            1..343
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    197..199
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="upstream in-frame stop codon"
     CDS             281..760
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="isoform c preproprotein is encoded by transcript
                     variant 3; somatomedin; IGF-I; Insulin-like growth factor
                     I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform c
                     preproprotein"
                     /protein_id="NP_001075947.1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
                     /translation="MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPTKSARSIRAQRHTDMPKTQKSQPLSTHKKRKLQRRRKGSTLEEHK"
     sig_peptide     281..424
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     proprotein      425..757
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform c
                     proprotein"
     mat_peptide     425..634
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform c"
     misc_feature    425..628
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    425..628
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    425..511
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: B"
     misc_feature    order(431..433,458..460,482..496)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(431..433,458..460,482..496)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(485..487,491..496,554..556)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(485..487,491..496,554..556)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    512..547
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: C"
     misc_feature    548..610
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: A"
     misc_feature    order(569..577,587..592)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(569..577,587..592)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    611..634
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: D"
     exon            344..500
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            501..682
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            683..734
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1879
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagggaga gagagagaag gcgaatgttc ccccagctgt ttcctgtcta cagtgtctgt
       61 gttttgtaga taaatgtgag gattttctct aaatccctct tctgcttgct aaatctcact
      121 gtcgctgcta aattcagagc agatagagcc tgcgcaatcg aaataaagtc ctcaaaattg
      181 aaatgtgact ttgctctaac atctcccatc tctctggatt tctttttgcc tcattattcc
      241 tgcccaccaa ttcatttcca gactttgtac ttcagaagcg atggggaaaa tcagcagtct
      301 tccaactcaa ttatttaaga tctgcctctg tgacttcttg aagataaaga tacacatcat
      361 gtcgtcttca catctcttct acctggcact ctgcttgctc acctttacca gctcggccac
      421 agccggacca gagacccttt gcggggctga gctggtggac gctcttcagt tcgtgtgtgg
      481 accaaggggc ttttacttca acaagcccac aggctatggc tccagcattc ggagggcacc
      541 acagacgggc attgtggatg agtgttgctt ccggagctgt gatctgagga ggctggagat
      601 gtactgtgct ccgctgaagc ctacaaagtc agctcgttcc atccgggccc agcgccacac
      661 tgacatgccc aagactcaga agtcccagcc cctatcgaca cacaagaaaa ggaagctgca
      721 aaggagaagg aaaggaagta cacttgaaga acacaagtag aggaagtgca ggaaacaaga
      781 cctacagaat gtaggaggag cctcccgagg aacagaaaat gccacgtcac cgcaagatcc
      841 tttgctgctt gagcaacctg caaaacatcg gaacacctgc caaatatcaa taatgagttc
      901 aataccattt cagagatggg catttccctc aatgaaatac acaagtaaac attccgacat
      961 tgtctttagg agtgtttgtt aaaaaaaaaa aaaaaaaaaa caaaaacaaa aacaaaaaaa
     1021 aaaagctttg caccttgcaa aagtggtcct ggcgtgggta gattgctgtt aatcctttat
     1081 caataacgtt ctatagagaa tatataaata tatatataat tatatctcct agtccctgcc
     1141 tcttaagagc cgaaaatgca tgggtgttgt agacattcgg ttgcactaaa ttcctctctg
     1201 aattttggct gctgaagccg ttcatttagc aactgtttat aggtggttga tgaatggttc
     1261 cttatctcca tttcttccta tgtagcttaa gccgcttcct tcacagaatc taataatctc
     1321 gtctaggcca ttagccctgc cctttcttaa cattcttgta tttgttgaat ttggcctcct
     1381 cgaaagcaat agcaactggg tggcccaccc aagttttaac gcccctgatt ccatctatgg
     1441 catttgtacc aaatataagt tggatgcatt tattttagac acaaagcttt attttttcga
     1501 catcgtgttt caagaaaaaa aacaaataga ataacaataa ctatgacttt gaggccaatc
     1561 atttttaggt gtgtgtttga agcatagaac gtctcttaaa ctctcaatgg ttccttcaaa
     1621 tgatgagtta gtatgtaacg taaatagcag tttctctctc tctctctctc tttttatttt
     1681 ttccatatag agcactatgt aaatttagca tatcaataat acaggaacta tcaaacagta
     1741 tgtaaactcc gttgttgttg tttttagtac aatggtgcta ttttgtagtt tgttctatga
     1801 aagaatctag tcaacacaga gaaaggagaa agcaaagcaa aaacaatgaa agcctggagc
     1861 ccaaaaggac aaaattagg
//
LOCUS       NM_012612                831 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus natriuretic peptide A (Nppa), mRNA.
ACCESSION   NM_012612
VERSION     NM_012612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Huang,Y., Wang,L.L., Liu,Z.B., Chen,C., Ren,X., Luo,A.T., Ma,J.H.,
            Antzelevitch,C., Barajas-Martinez,H. and Hu,D.
  TITLE     Underlying mechanism of atrial fibrillation-associated Nppa-I137T
            mutation and cardiac effect of potential drug therapy
  JOURNAL   Heart Rhythm 21 (2), 184-196 (2024)
   PUBMED   37924963
  REMARK    GeneRIF: Underlying mechanism of atrial fibrillation-associated
            Nppa-I137T mutation and cardiac effect of potential drug therapy.
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Dogra,A., Kour,D., Gour,A., Bhardwaj,M., Bag,S., Dhiman,S.K.,
            Kumar,A., Singh,G. and Nandi,U.
  TITLE     Ameliorating effect of rutin against diclofenac-induced cardiac
            injury in rats with underlying function of FABP3, MYL3, and ANP
  JOURNAL   Drug Chem Toxicol 46 (3), 597-608 (2023)
   PUBMED   35509154
  REMARK    GeneRIF: Ameliorating effect of rutin against diclofenac-induced
            cardiac injury in rats with underlying function of FABP3, MYL3, and
            ANP.
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Zhang,Y., Wang,S., Huang,Y., Yang,K., Liu,Y., Bi,X., Liu,C.,
            Xiong,J., Zhang,B., Zhao,J. and Nie,L.
  TITLE     Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by
            uremic toxin
  JOURNAL   Mol Med Rep 21 (1), 393-404 (2020)
   PUBMED   31746392
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Li,X., Han,Z.N., Liu,Y., Hong,L., Cui,B.R. and Cui,X.
  TITLE     Endogenous ET-1 promotes ANP secretion through activation of
            COX2-L-PGDS-PPARgamma signaling in hypoxic beating rat atria
  JOURNAL   Peptides 122, 170150 (2019)
   PUBMED   31541683
  REMARK    GeneRIF: These results indicate that endogenous ET-1 induced by
            hypoxia promotes hypoxia-induced ANP secretion by activation of
            COX2-L-PGDS-PPARgamma signaling in beating rat atria
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Yu,L., Li,W., Park,B.M., Lee,G.J. and Kim,S.H.
  TITLE     Hypoxia augments NaHS-induced ANP secretion via KATP channel,
            HIF-1alpha and PPAR-gamma pathway
  JOURNAL   Peptides 121, 170123 (2019)
   PUBMED   31386893
  REMARK    GeneRIF: Hypoxia augments NaHS-induced ANP secretion via KATP
            channel, HIF-1A and PPAR-gamma pathway.
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Ramirez,G., Saba,S.R., Dietz,J.R. and Vesely,D.L.
  TITLE     Immunocytochemical localization of proANF 1-30, proANF 31-67 and
            atrial natriuretic factor in the kidney
  JOURNAL   Kidney Int 41 (2), 334-341 (1992)
   PUBMED   1372667
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Levin,E.R. and Frank,H.J.
  TITLE     Natriuretic peptides inhibit rat astroglial proliferation:
            mediation by C receptor
  JOURNAL   Am J Physiol 261 (2 Pt 2), R453-R457 (1991)
   PUBMED   1652217
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   10 (bases 1 to 831)
  AUTHORS   Jin,H., Yang,R.H., Chen,Y.F., Jackson,R.M. and Oparil,S.
  TITLE     Atrial natriuretic peptide attenuates the development of pulmonary
            hypertension in rats adapted to chronic hypoxia
  JOURNAL   J Clin Invest 85 (1), 115-120 (1990)
   PUBMED   2136863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB724799.1, X00665.1 and AI602287.1.
            
            On Oct 17, 2007 this sequence version replaced NM_012612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV765126.1, BC158590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CB724799.1         128-135
            9-576               X00665.1           1-568
            577-831             AI602287.1         1-255               c
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..831
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="natriuretic peptide A"
                     /db_xref="GeneID:24602"
                     /db_xref="RGD:3193"
     exon            1..196
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
     unsure          9..14
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="pot. cloning artefact"
     CDS             77..535
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Natriuretic peptide precursor A (pronatriodilatin,
                     also Anf, Pnd); natriuretic peptides A;
                     prepronatriodilatin; natriuretic peptide precursor type A;
                     proANF; proANP; preproANF; preproANP; atriopeptigen;
                     cardiodilatin; preproCDD-ANF; atrial natriuretic factor
                     prohormone; atrial natriuretic peptide prohormone"
                     /codon_start=1
                     /product="natriuretic peptides A precursor"
                     /protein_id="NP_036744.1"
                     /db_xref="GeneID:24602"
                     /db_xref="RGD:3193"
                     /translation="MGSFSITKGFFLFLAFWLPGHIGANPVYSAVSNTDLMDFKNLLD
                     HLEEKMPVEDEVMPPQALSEQTDEAGAALSSLSEVPPWTGEVNPSQRDGGALGRGPWD
                     PSDRSALLKSKLRALLAGPRSLRRSSCFGGRIDRIGAQSGLGCNSFRYRR"
     sig_peptide     77..148
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     149..526
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /product="Natriuretic peptides A.
                     /evidence=ECO:0000250|UniProtKB:P01160.
                     /id=PRO_0000449770"
                     /note="propagated from UniProtKB/Swiss-Prot (P01161.1)"
     misc_feature    236..388
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="propagated from UniProtKB/Swiss-Prot (P01161.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    440..511
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Natriuretic peptide; Region: NAT_PEP; smart00183"
                     /db_xref="CDD:128480"
     misc_feature    440..511
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Natriuretic peptide; Region: NAT_PEP; smart00183"
                     /db_xref="CDD:128480"
     misc_feature    440..445
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Cleavage, by CORIN.
                     /evidence=ECO:0000250|UniProtKB:P01160; propagated from
                     UniProtKB/Swiss-Prot (P01161.1); cleavage site"
     misc_feature    458..460
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01160; propagated from
                     UniProtKB/Swiss-Prot (P01161.1); phosphorylation site"
     misc_feature    461..466
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="Cleavage, by MME.
                     /evidence=ECO:0000269|PubMed:2966343; propagated from
                     UniProtKB/Swiss-Prot (P01161.1); cleavage site"
     misc_feature    512..526
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="propagated from UniProtKB/Swiss-Prot (P01161.1);
                     Region: Important for degradation of atrial natriuretic
                     peptide by IDE. /evidence=ECO:0000250|UniProtKB:P01160"
     prim_transcript 149..532
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="AFN"
     exon            197..523
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    449..454
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="pot. proteolytic processing site"
     exon            524..814
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    527..532
                     /gene="Nppa"
                     /gene_synonym="ANF; ANP; CDD; Pnd; RATANF"
                     /note="pot. proteolytic processing site"
ORIGIN      
        1 cggacaaagg ctgagagaga aaccagagag tgagccgaga cagcaaacat cagatcgtgc
       61 cccgacccac gccagcatgg gctccttctc catcaccaag ggcttcttcc tcttcctggc
      121 cttttggctc ccaggccata ttggagcaaa tcccgtatac agtgcggtgt ccaacacaga
      181 tctgatggat ttcaagaacc tgctagacca cctggaggag aagatgccgg tagaagatga
      241 ggtcatgcct ccgcaggccc tgagcgagca gaccgatgaa gcgggggcgg cacttagctc
      301 cctctctgag gtgcctccct ggactgggga agtcaacccg tctcagagag atggaggtgc
      361 tctcgggcgc ggcccctggg acccctccga tagatctgcc ctcttgaaaa gcaaactgag
      421 ggctctgctc gctggccctc ggagcctgcg aaggtcaagc tgcttcgggg gtaggattga
      481 caggattgga gcccagagcg gactaggctg caacagcttc cggtaccgaa gataacagcc
      541 aaatctgctc gagcagatcg caaaagatcc caagcccttg cggtgtgtca cacagcttgg
      601 tcgcattgcc actgagaggt ggtgaatacc ctcctggagc tgcagcttcc tgtcttcatc
      661 tatcacgatc gatgttaagt gtagatgagt ggtttagtga ggccttacct ctcccactct
      721 gcatattaag gtagatcctc acccctttca gaaagcagtt ggaaaaaaat aaatccgaat
      781 aaacttcagc accacggaca gacgctgagg cctgaaaaaa aaaaaaaaaa a
//
LOCUS       NM_001429650            4057 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus sarcosine dehydrogenase (Sardh), transcript
            variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001429650 XM_006233731
VERSION     NM_001429650.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4057)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 4057)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   3  (bases 1 to 4057)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 4057)
  AUTHORS   Bergeron,F., Otto,A., Blache,P., Day,R., Denoroy,L., Brandsch,R.
            and Bataille,D.
  TITLE     Molecular cloning and tissue distribution of rat sarcosine
            dehydrogenase
  JOURNAL   Eur J Biochem 257 (3), 556-561 (1998)
   PUBMED   9839943
REFERENCE   5  (bases 1 to 4057)
  AUTHORS   Porter,D.H., Cook,R.J. and Wagner,C.
  TITLE     Enzymatic properties of dimethylglycine dehydrogenase and sarcosine
            dehydrogenase from rat liver
  JOURNAL   Arch Biochem Biophys 243 (2), 396-407 (1985)
   PUBMED   2417560
REFERENCE   6  (bases 1 to 4057)
  AUTHORS   Cook,R.J., Misono,K.S. and Wagner,C.
  TITLE     The amino acid sequences of the flavin-peptides of dimethylglycine
            dehydrogenase and sarcosine dehydrogenase from rat liver
            mitochondria
  JOURNAL   J Biol Chem 260 (24), 12998-13002 (1985)
   PUBMED   4055729
REFERENCE   7  (bases 1 to 4057)
  AUTHORS   Wittwer,A.J. and Wagner,C.
  TITLE     Identification of the folate-binding proteins of rat liver
            mitochondria as dimethylglycine dehydrogenase and sarcosine
            dehydrogenase. Flavoprotein nature and enzymatic properties of the
            purified proteins
  JOURNAL   J Biol Chem 256 (8), 4109-4115 (1981)
   PUBMED   6163778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 24, 2024 this sequence version replaced XM_006233731.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.14641.1,
                                           SRR26643294.12389.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000003.1  30972110-30972136   c
            28-70               JAXUCZ010000003.1  30971525-30971567   c
            71-425              JAXUCZ010000003.1  30968824-30969178   c
            426-604             JAXUCZ010000003.1  30967389-30967567   c
            605-784             JAXUCZ010000003.1  30966172-30966351   c
            785-908             JAXUCZ010000003.1  30962700-30962823   c
            909-1009            JAXUCZ010000003.1  30962452-30962552   c
            1010-1114           JAXUCZ010000003.1  30959047-30959151   c
            1115-1244           JAXUCZ010000003.1  30957866-30957995   c
            1245-1331           JAXUCZ010000003.1  30954163-30954249   c
            1332-1422           JAXUCZ010000003.1  30953836-30953926   c
            1423-1564           JAXUCZ010000003.1  30951736-30951877   c
            1565-1648           JAXUCZ010000003.1  30949484-30949567   c
            1649-1762           JAXUCZ010000003.1  30947283-30947396   c
            1763-1901           JAXUCZ010000003.1  30942955-30943093   c
            1902-2015           JAXUCZ010000003.1  30941162-30941275   c
            2016-2163           JAXUCZ010000003.1  30936272-30936419   c
            2164-2257           JAXUCZ010000003.1  30932290-30932383   c
            2258-2420           JAXUCZ010000003.1  30917468-30917630   c
            2421-2589           JAXUCZ010000003.1  30916574-30916742   c
            2590-2725           JAXUCZ010000003.1  30911991-30912126   c
            2726-4057           JAXUCZ010000003.1  30908621-30909952   c
FEATURES             Location/Qualifiers
     source          1..4057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..4057
                     /gene="Sardh"
                     /note="sarcosine dehydrogenase"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
     exon            1..27
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            28..70
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            71..425
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    83..85
                     /gene="Sardh"
                     /note="upstream in-frame stop codon"
     CDS             92..2851
                     /gene="Sardh"
                     /EC_number="1.5.8.3"
                     /codon_start=1
                     /product="sarcosine dehydrogenase, mitochondrial"
                     /protein_id="NP_001416579.1"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
                     /translation="MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQC
                     TLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERL
                     TSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQ
                     QRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTC
                     TTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWA
                     SSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEA
                     NPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHK
                     PLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSL
                     TDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWER
                     PGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACR
                     TAAAVFNMSYFGKFYLLGADARKAADWLFSADVNRPPGSTVYTCMLNQRGGTESDLTV
                     SCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLG
                     MLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHV
                     PQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAF
                     TCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRA
                     DFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKR
                     VKGIY"
     transit_peptide 92..157
                     /gene="Sardh"
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q64380.2)"
     mat_peptide     158..2848
                     /gene="Sardh"
                     /product="Sarcosine dehydrogenase, mitochondrial.
                     /id=PRO_0000010772"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64380.2)"
     misc_feature    290..1426
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    290..1426
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    611..613
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    1382..1549
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1382..1549
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1532..2842
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1532..2842
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1769..1771
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2417..2419
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2423..2425
                     /gene="Sardh"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UL12; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); phosphorylation site"
     misc_feature    2498..2500
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2744..2746
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2804..2806
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     exon            426..604
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            605..784
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            785..908
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1009
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1114
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1244
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1331
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1422
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1564
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1648
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1762
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1901
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2015
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2163
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2257
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2420
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2589
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2725
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..4057
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtcctgac agccccttca tgggcaggaa tctcccagga gcttctggaa aatctaggac
       61 gaagactaag gtacaggagc cctaagtccc catggcttca ctgagccggg tcctccgtgt
      121 agctgccacc tgtcctcgag ggagatctgc tcgcaacctg gggctacagc ccctagccag
      181 ggaggccagg cccaccactg agaagagtgt tccataccag tgcaccctga aggaggaggc
      241 ccaaggtgcc tctgtggtgc cccaaggacc aagccagccc ctgcctagca cagccaatgt
      301 tgtggtcatt ggtgggggca gtttgggctg ccagactctg taccacttgg ccaagctggg
      361 tgtaggtgga gttgtgctgc tggagagaga gcgactgacc tctgggacca cctggcacac
      421 agcaggccta ctgtggcagc tgcggcccag cgatgtggaa gtagagcttc tggctcacac
      481 acggcaagtg gtgagccatg atctggaaga ggagactggg cttcacacag gctggatcca
      541 gaatggtggc ctcttcatcg cctccaacca gcagcgcctg gatgaataca agaggctcat
      601 gtcgttgggc aaggcctacg gtatagaatc ccatgtgctg agccctgcag agaccaagga
      661 tctgtatccg ctgatgaatg tggacgacct ctatgggacc ctgtatgtgc ctcgggatgg
      721 taccatggac ccggctggca cctgcactac cctcaccaga gcagcagtgg ctaggggagc
      781 tcaggtcatt gaaaactgtg cagtgactgg catccgtgtg cggacagacg actttggagt
      841 gcggcgggtg acagctgtgg agactcaaca tggctccatc cagacaccct gcgtggtcaa
      901 ctgtgcaggg gtgtgggcga gctccgtggg ccggatggct ggagtgaagg tcccgctggt
      961 ggccatgcac catgcctacg ttgtcactga gcgcattgag gggatccaga acatgcccaa
     1021 tgtccgggat catgatgctt ctgtctacct ccgcctgcag ggggatgcct tgtctgtggg
     1081 tggctatgag gccaacccca tcttttggga tgaggtgtca gacaaatttg cctttggcct
     1141 ctttgacctg gactgggatg tgttcactca gcacattgaa ggtgccatta accgtgtccc
     1201 cgtgttggag aaaacgggga tcaagtccac tgtctgtggc cctgaatcct tcacacccga
     1261 ccataagccc ctgatggggg aggctcctga gctccgaggc ttcttccttg gctgtggctt
     1321 caacagtgca ggcatgatgt tgggtggtgg ctgtggacag gagctggccc attggattgt
     1381 gcatgggcgc ccagagaagg acatgtacag ctatgacatc aggcgtttcc accactcgct
     1441 cacggaccac ccacgctgga tccgagagcg cagccacgag tcctatgcca agaactactc
     1501 ggttgtcttt cctcacgatg agcccctggc gggccgcaac atgaggaggg accctctgca
     1561 cgaggagctg cttggacaag gctgtgtgtt tcaagaacga cagggctggg aacggccagg
     1621 atggttcaac ccccaagaaa cagctcaggt cctagactac gactactatg gggcctacgg
     1681 acaccaggca cacaaggact acgcctacag caggctgctg ggcgatgaat ataccttcga
     1741 cttcccaccc caccactgcg tgatccagaa ggaatgtctg gcctgcagaa cggctgccgc
     1801 cgtgttcaac atgtcttact tcgggaagtt ctaccttctg ggggcagacg ccaggaaggc
     1861 tgcagactgg ctcttctcag cagatgtcaa ccgaccccca ggctccacgg tgtacacatg
     1921 catgctgaac caacggggag gcaccgagag cgacctgact gttagctgcc tggcccctgg
     1981 tgcccaggcc agtcccctgg cccctgcctt tgaaggggat ggctactacc tagccgtagg
     2041 tggggctgtg gcccaacata actggtccca cataaacacg gtgctgcagg atcaggagtt
     2101 ccggtgccag cttatggatt gttctgaaga tctgggcatg ctcagtatcc agggcccagc
     2161 cagccgtgac attctccagg atgtgcttga tgctgacctg agcaatgaag ccttcccctt
     2221 ctccacccac cagctggtga gagctgctgg acacctggtc cgagccatcc ggctatcctt
     2281 tgtcggggag ctgggatggg agctgcatgt gccccaagcg tcctgcttgc ctgtgtaccg
     2341 ggctgtgatg gctgcagggg cgaagcacgg cctagtcaat gcaggctacc gtgccatcga
     2401 ctccctgagc attgagaaag gctatcggca ctggcatgca gacctgaggt ccgatgacag
     2461 ccccctggag gcagggttgg ccttcacctg caagctcaag acctcagtgc ccttcctagg
     2521 ccgagaggcc ctggagaagc agcgtgccac aggcctccga cgacgcctgg tgtgcctcac
     2581 tgtggaagag gaggttccta tgttcggcct agaggccatc tggagaaatg gccaagtggt
     2641 gggccatgtc cggagagctg actttggatt caccgtgaac aagaccatcg cctatggcta
     2701 catccgagac cccagtggag ggccagtctc tctggacttt gtgaagaatg gggactatgc
     2761 cttggagaga atgggggtca cctatgctgc ccaggttcac ctgaagtctc cctttgatcc
     2821 tgacaacaag cgggtgaagg gaatctattg atgggctgca gggtggaggc tacagctgct
     2881 caggcccctg gaaactgcca cacttcccat acggcctgtg gactcctata ctgtacaaac
     2941 agccctgtgt cctgagaccc aagataaggg caaaacacag acttcccacc ctgagcctcc
     3001 atctggtcct gctaactgcc acagctccta accagtacca catggaccac tatgttcctc
     3061 ctgctcacag accacacagt ggtctccaat ccactctagc cctcccaaaa tgcaccctgc
     3121 agatgtctgg gctcaaggtc cctgtgtatg gttaacccaa gatagaagcc ataaagcaag
     3181 caggcatcca gtctgtccct cacttggctg actgcagtgg gtagctggag tgtctgaagg
     3241 gtagtggatt gggagagtga gcagggattg atgagtaatg tctgccatgg gtataggatg
     3301 gaggacacag agacaggtgc tggactggta cagtccttct tcggaatggt tgccttttag
     3361 accagagaga agaaggataa gcaggctctt gcccctagcc ttccagctct gcaggagaga
     3421 aagccttctg agagtcacca accagtgaca cagaaggcat gtggcatggg atttggatca
     3481 ggaacctcac ttacaaagaa gtgtcatact ctgcctcagt ttcccctcaa gccattgctc
     3541 atgggtctgg agacaccaag ctttcactcg tgcataaccc agctgcagtg tatgtttcca
     3601 aggacttttt atttctgtca cagatgcatg gcttcctgat caagctctag tgaggggctg
     3661 ctccagttct gctttgtgag atagagtggc ctcttctccc accctgtgta accatccaca
     3721 tatgtcctca tatcaggggc accctgcctc tccttcctgg ggtgaacagc catcactttt
     3781 ctgtagaccc aaccttcttc ctctgtctca cgccctgact gagaaatcgg gctgctgtag
     3841 ctccccaaac aaagatcacc gtgtagcctt atgtgccttg tagtctagga gagaaggagg
     3901 ccattgcagt atggagttgg gtgtcttaaa cccaaagaag tcagcagaag ggagatgtgg
     3961 gcacaattgt cctgggtggg ctctgaatct tcatagattc acacaccaca cactgtgccg
     4021 gaaaaaggtc aagttaataa aattttacga aaccgtt
//
LOCUS       NM_031107               3120 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A1 (Rps6ka1), mRNA.
ACCESSION   NM_031107
VERSION     NM_031107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3120)
  AUTHORS   Takegaki,J., Sase,K. and Fujita,S.
  TITLE     Repeated bouts of resistance exercise attenuate mitogen-activated
            protein-kinase signal responses in rat skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 520 (1), 73-78 (2019)
   PUBMED   31582215
  REMARK    GeneRIF: repeated bouts of resistance training desensitized ERK1/2
            and p38 MAPK, subsequently attenuating p90RSK phosphorylation in a
            rat model
REFERENCE   2  (bases 1 to 3120)
  AUTHORS   Han,J.H., Kim,S., Kim,S., Lee,H., Park,S.Y. and Woo,C.H.
  TITLE     FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP
            Expression via Regulation of ChREBP in Pancreatic beta Cells
  JOURNAL   Int J Mol Sci 20 (18), 4424 (2019)
   PUBMED   31505737
  REMARK    GeneRIF: FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced
            TXNIP Expression via Regulation of ChREBP in Pancreatic beta Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3120)
  AUTHORS   Dou,X., Menkari,C., Mitsuyama,R., Foroud,T., Wetherill,L.,
            Hammond,P., Suttie,M., Chen,X., Chen,S.Y. and Charness,M.E.
  CONSRTM   Collaborative Initiative on Fetal Alcohol Spectrum Disorders
  TITLE     L1 coupling to ankyrin and the spectrin-actin cytoskeleton
            modulates ethanol inhibition of L1 adhesion and ethanol
            teratogenesis
  JOURNAL   FASEB J 32 (3), 1364-1374 (2018)
   PUBMED   29109170
REFERENCE   4  (bases 1 to 3120)
  AUTHORS   Carretero,L., Llavona,P., Lopez-Hernandez,A., Casado,P.,
            Cutillas,P.R., de la Pena,P., Barros,F. and Dominguez,P.
  TITLE     ERK and RSK are necessary for TRH-induced inhibition of r-ERG
            potassium currents in rat pituitary GH3 cells
  JOURNAL   Cell Signal 27 (9), 1720-1730 (2015)
   PUBMED   26022182
  REMARK    GeneRIF: in the native GH3 cell system, ERK and RSK are involved in
            the pathway linking TRH receptor to r-ERG channel inhibition, but
            additional components must participate to cause such inhibition.
REFERENCE   5  (bases 1 to 3120)
  AUTHORS   Seow,K.H., Zhou,L., Stephanopoulos,G. and Too,H.P.
  TITLE     c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12
            cells mediated through P90RSK
  JOURNAL   BMC Neurosci 14, 153 (2013)
   PUBMED   24330599
  REMARK    GeneRIF: Our findings demonstrate a hitherto unrecognized mechanism
            of c-Jun N-terminal kinase-P90RSK in mediating synergistic neurite
            outgrowth
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3120)
  AUTHORS   Buck,M., Poli,V., van der Geer,P., Chojkier,M. and Hunter,T.
  TITLE     Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP
            beta is required for hepatocyte proliferation induced by TGF alpha
  JOURNAL   Mol Cell 4 (6), 1087-1092 (1999)
   PUBMED   10635333
REFERENCE   7  (bases 1 to 3120)
  AUTHORS   Suzuki,T., Mitake,S. and Murata,S.
  TITLE     Presence of up-stream and downstream components of a
            mitogen-activated protein kinase pathway in the PSD of the rat
            forebrain
  JOURNAL   Brain Res 840 (1-2), 36-44 (1999)
   PUBMED   10517950
REFERENCE   8  (bases 1 to 3120)
  AUTHORS   Smith,J.A., Poteet-Smith,C.E., Malarkey,K. and Sturgill,T.W.
  TITLE     Identification of an extracellular signal-regulated kinase (ERK)
            docking site in ribosomal S6 kinase, a sequence critical for
            activation by ERK in vivo
  JOURNAL   J Biol Chem 274 (5), 2893-2898 (1999)
   PUBMED   9915826
REFERENCE   9  (bases 1 to 3120)
  AUTHORS   Wong,E.V., Schaefer,A.W., Landreth,G. and Lemmon,V.
  TITLE     Involvement of p90rsk in neurite outgrowth mediated by the cell
            adhesion molecule L1
  JOURNAL   J Biol Chem 271 (30), 18217-18223 (1996)
   PUBMED   8663493
REFERENCE   10 (bases 1 to 3120)
  AUTHORS   Grove,J.R., Price,D.J., Banerjee,P., Balasubramanyam,A., Ahmad,M.F.
            and Avruch,J.
  TITLE     Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by
            phorbol ester and erk/MAP kinase
  JOURNAL   Biochemistry 32 (30), 7727-7738 (1993)
   PUBMED   7688567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031107.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99169.1, SRR22582416.149335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000005.1  151401860-151402064 c
            206-250             JAXUCZ010000005.1  151395810-151395854 c
            251-367             JAXUCZ010000005.1  151386879-151386995 c
            368-449             JAXUCZ010000005.1  151386551-151386632 c
            450-530             JAXUCZ010000005.1  151384193-151384273 c
            531-610             JAXUCZ010000005.1  151383928-151384007 c
            611-717             JAXUCZ010000005.1  151382207-151382313 c
            718-755             JAXUCZ010000005.1  151381180-151381217 c
            756-898             JAXUCZ010000005.1  151380572-151380714 c
            899-969             JAXUCZ010000005.1  151380131-151380201 c
            970-1058            JAXUCZ010000005.1  151379783-151379871 c
            1059-1123           JAXUCZ010000005.1  151378780-151378844 c
            1124-1226           JAXUCZ010000005.1  151378439-151378541 c
            1227-1357           JAXUCZ010000005.1  151376029-151376159 c
            1358-1483           JAXUCZ010000005.1  151375381-151375506 c
            1484-1573           JAXUCZ010000005.1  151375074-151375163 c
            1574-1732           JAXUCZ010000005.1  151374227-151374385 c
            1733-1894           JAXUCZ010000005.1  151366340-151366501 c
            1895-1971           JAXUCZ010000005.1  151366074-151366150 c
            1972-2089           JAXUCZ010000005.1  151365837-151365954 c
            2090-2227           JAXUCZ010000005.1  151364117-151364254 c
            2228-3120           JAXUCZ010000005.1  151362819-151363711 c
FEATURES             Location/Qualifiers
     source          1..3120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3120
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ribosomal protein S6 kinase A1"
                     /db_xref="GeneID:81771"
                     /db_xref="RGD:620675"
     exon            1..205
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2350
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /EC_number="2.7.11.1"
                     /note="RSK-1; p90S6K; pp90RSK1; ribosomal protein S6
                     kinase polypeptide 1; MAPKAPK1A; p90-RSK 1; ribosomal S6
                     kinase 1; ribosomal protein S6 kinase, polypeptide A1; 90
                     kDa ribosomal protein S6 kinase 1; MAP kinase-activated
                     protein kinase 1a; p90RSK1; MAPKAPK-1a; S6K-alpha-1;
                     MAPKAP kinase 1a; MAPK-activated protein kinase 1a; S6
                     protein kinase (Rsk-1)"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-1"
                     /protein_id="NP_112369.2"
                     /db_xref="GeneID:81771"
                     /db_xref="RGD:620675"
                     /translation="MPLAQLKEPWPLMELVPLDPENGQASGEEAGLQPSKDEGILKEI
                     SITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLK
                     VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT
                     EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK
                     AYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK
                     AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREI
                     KPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDSK
                     PRATQAPLHSVVQQLHGKNLVFSDGYIVKETIGVGSYSVCKRCVHKATNMEYAVKVID
                     KSKRDPSEEIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFS
                     EREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA
                     ENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEE
                     ILTRISSGKFTLNGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLP
                     QSQLSHQDLQLVKGAMAATYSALSSSKPTPQLKPIESSILAQRRVRKLPSTTL"
     misc_feature    302..304
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    338..1288
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="N-terminal catalytic domain of the Serine/Threonine
                     Kinase, 90 kDa ribosomal protein S6 kinase; Region:
                     STKc_RSK_N; cd05582"
                     /db_xref="CDD:270734"
     misc_feature    338..1288
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="N-terminal catalytic domain of the Serine/Threonine
                     Kinase, 90 kDa ribosomal protein S6 kinase; Region:
                     STKc_RSK_N; cd05582"
                     /db_xref="CDD:270734"
     misc_feature    order(344..358,368..370,416..418,422..424,515..517,
                     563..568,572..574,584..586,590..592,701..703,707..709,
                     713..718,722..724,752..757,764..766,806..823,902..904,
                     920..922,929..931)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="active site"
                     /db_xref="CDD:270734"
     misc_feature    order(344..358,368..370,416..418,422..424,515..517,
                     563..568,572..574,584..586,590..592,701..703,707..709,
                     713..718,722..724,752..757,764..766,806..823,902..904,
                     920..922,929..931)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="active site"
                     /db_xref="CDD:270734"
     misc_feature    order(344..358,368..370,416..418,422..424,515..517,
                     566..574,584..586,701..703,707..709,713..718,722..724,
                     752..757)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270734"
     misc_feature    order(344..358,368..370,416..418,422..424,515..517,
                     566..574,584..586,701..703,707..709,713..718,722..724,
                     752..757)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270734"
     misc_feature    order(356..358,584..586,590..592,701..703,707..709,
                     713..715,764..766,806..823,902..904,920..922,929..931)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270734"
     misc_feature    order(356..358,584..586,590..592,701..703,707..709,
                     713..715,764..766,806..823,902..904,920..922,929..931)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270734"
     misc_feature    order(752..787,791..823)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270734"
     misc_feature    order(752..787,791..823)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270734"
     misc_feature    803..805
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine, by PDPK1.
                     /evidence=ECO:0000269|PubMed:10480933; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1061..1063
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1217..1219
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1229..1231
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1229..1231
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:270734"
     misc_feature    1229..1231
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:270734"
     misc_feature    1247..1249
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1268..1285
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270734"
     misc_feature    1268..1285
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270734"
     misc_feature    1280..1282
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    1388..2260
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="C-terminal catalytic domain of the Serine/Threonine
                     Kinase, Ribosomal S6 kinase 1 (also called Ribosomal
                     protein S6 kinase alpha-1 or 90kDa ribosomal protein S6
                     kinase 1); Region: STKc_RSK1_C; cd14175"
                     /db_xref="CDD:271077"
     misc_feature    1388..2260
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="C-terminal catalytic domain of the Serine/Threonine
                     Kinase, Ribosomal S6 kinase 1 (also called Ribosomal
                     protein S6 kinase alpha-1 or 90kDa ribosomal protein S6
                     kinase 1); Region: STKc_RSK1_C; cd14175"
                     /db_xref="CDD:271077"
     misc_feature    order(1412..1426,1436..1438,1475..1477,1481..1483,
                     1559..1561,1607..1618,1628..1630,1634..1636,1742..1747,
                     1751..1753,1757..1762,1766..1768,1808..1813,1820..1822,
                     1865..1879,1883..1885)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="active site"
                     /db_xref="CDD:271077"
     misc_feature    order(1412..1426,1436..1438,1475..1477,1481..1483,
                     1559..1561,1607..1618,1628..1630,1634..1636,1742..1747,
                     1751..1753,1757..1762,1766..1768,1808..1813,1820..1822,
                     1865..1879,1883..1885)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="active site"
                     /db_xref="CDD:271077"
     misc_feature    order(1412..1423,1436..1438,1475..1477,1481..1483,
                     1559..1561,1607..1618,1628..1630,1757..1762,1766..1768,
                     1808..1813)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271077"
     misc_feature    order(1412..1423,1436..1438,1475..1477,1481..1483,
                     1559..1561,1607..1618,1628..1630,1757..1762,1766..1768,
                     1808..1813)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271077"
     misc_feature    order(1424..1426,1628..1630,1634..1636,1742..1747,
                     1751..1753,1757..1759,1820..1822,1865..1879,1883..1885)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271077"
     misc_feature    order(1424..1426,1628..1630,1634..1636,1742..1747,
                     1751..1753,1757..1759,1820..1822,1865..1879,1883..1885)
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271077"
     misc_feature    1808..1879
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271077"
     misc_feature    1808..1879
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271077"
     misc_feature    1859..1861
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     misc_feature    2336..2338
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15418; propagated from
                     UniProtKB/Swiss-Prot (Q63531.1); phosphorylation site"
     exon            206..250
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..367
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..449
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..530
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..610
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..717
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..755
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..898
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..969
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1058
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1123
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1226
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1357
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1483
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1573
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1732
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1894
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1971
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2089
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2227
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..3120
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcggc ggacggccca gccagagcgc gaggggctcg ggggcgtgcg ggggtctcgg
       61 tgcagcagca aggaccccgg ggcccagagg cggcacagcc cggggccgcc cggaggagcg
      121 cgggcggtcc ggcggcggcg cgatgccgct cgcccagctc aaggaaccct ggccgctcat
      181 ggagctggtg ccgctggacc cggagaatgg acaggcttca ggggaagaag ctggacttca
      241 gccatccaag gatgagggca tcctcaagga gatctctatc acacaccacg tcaaggctgg
      301 ctctgagaag gctgatccat cccattttga gctcctcaag gttctgggcc aaggatcctt
      361 tggcaaagtc ttcctggtac gcaaggtcac ccggcctgac aatgggcact tgtatgccat
      421 gaaagtatta aagaaggcca cgctgaaagt gcgtgaccgt gttcggacca agatggagag
      481 agacatccta gctgacgtga accacccctt cgtagtgaaa ctgcactatg ccttccagac
      541 cgagggcaag ctctatctta ttctggactt tctgcgtggt ggagacctgt tcacacgact
      601 ctcaaaggag gttatgttta cagaggagga tgtgaagttt tacctggctg agctggcact
      661 gggcctggac cacctgcaca gcttgggcat catttacaga gacctcaagc ctgagaatat
      721 ccttttggat gaggagggcc acatcaaact cactgacttt ggcctgagca aggaggccat
      781 tgaccacgaa aagaaggcct attccttctg cgggacggtg gagtacatgg cccccgaggt
      841 tgtcaaccgc cagggccaca cccacagtgc agattggtgg tcctatgggg tgttgatgtt
      901 tgagatgctg acgggctccc tgcccttcca ggggaaggac cggaaggaga ccatgacctt
      961 gattttgaag gcaaagctag gcatgcccca gtttctgagc acggaagccc agagcctcct
     1021 gcgggccctg ttcaagagga atcctgccaa ccggcttggc tcaggccccg atggggctga
     1081 ggaaattaag agacatatct tctactctac cattgactgg aataagctct accgccgtga
     1141 gatcaagcca cctttcaagc ccgctgtggc ccagccggat gacaccttct actttgatac
     1201 cgagttcacg tcacgcacac ccagggattc gccgggcatc ccccccagtg ctggtgccca
     1261 tcagctcttc cgtggcttca gcttcgtggc caccggtctg atggaggatg acagcaagcc
     1321 tcgggccacc caggctccgc tgcactcggt ggtacagcaa ctccacggga agaacttggt
     1381 tttcagcgat ggctacatag taaaggagac gatcggcgtg ggctcctact ctgtgtgtaa
     1441 gcgctgtgtc cacaaggcca ccaacatgga gtacgcagtc aaagtcatcg acaaaagcaa
     1501 aagagatccc tccgaagaga tcgagattct tctgcggtat ggacagcacc ccaacatcat
     1561 caccctgaaa gatgtgtatg acgacagtaa gcacgtatac ctggtgacag agctgatgag
     1621 gggcggggag ctgctggata agatcctacg gcagaaattc ttctcagagc gggaggccag
     1681 cttcgtcctg tacaccatca gcaagactgt ggaatacttg cactcccaag gggtcgtcca
     1741 cagggacctc aaacccagta acatcctgta tgtggatgag tctgggaacc ccgaatgcct
     1801 acgaatatgc gactttggct ttgccaagca gctacgggct gagaacgggc ttctcatgac
     1861 accttgctac acagccaact ttgtggcacc tgaggtgctg aagcgtcagg gctacgatga
     1921 aggctgtgac atatggagcc tgggcgttct gctgtacacg atgctggcag gatacactcc
     1981 atttgccaat gggcccagtg ataccccaga ggagatcctc acccggatca gcagtgggaa
     2041 gttcaccctc aacgggggaa actggaacac ggtttcagag acagccaagg acttagtatc
     2101 taagatgctg catgtggacc cccaccagcg cctcacagcc aaacaggttc tgcagcaccc
     2161 gtggatcacc cagaaagaca agctccccca gagccagttg tcccaccaag acctgcagct
     2221 tgtgaagggg gccatggcag ctacatattc tgcactcagt agctccaaac ccacccccca
     2281 gctcaagcca atcgagtcgt ccatcctggc ccagcggcgg gtgaggaagc tgccatccac
     2341 caccctgtga accgcagcgc agacaaactc cttggaggca gagtccttcc cagagggagc
     2401 aagcctgagt cacaggacca agtggaatgg agtcctaaag gaagcaacta gcccagctca
     2461 cccgtgcggg tgtgaagtgc cttcctcccc aggacgggct cttctgggct caggctccat
     2521 tgtgtgaaat ccactcactg tacaaactat tttttaagaa aggaaaagaa aaatgacatc
     2581 atttaccatg gatttttttt ttacaagatc catttgcctt tttggccatt gcagtcccag
     2641 gaggaacacc cagtcccatg tgtggccaag actcccgtga tagctttggg actccgcccc
     2701 tctgttggtc aaggagccat ctgcacccgc ctccgagcag ttcggcgttg cctctcagag
     2761 ttgtcgactg gctcctcagc agaacttggt gtccccagcc atctcttttt ccattctgtt
     2821 ctggggttct cgaaccactt tctgctaaga gcccgggacc ccaccctgtc agctcttggc
     2881 tccaggcacc agcatccaca gcgcccatgc gcagtgggcc cctgcagtca gaacgggcag
     2941 ccccgtggag aggagacgga gagcactttt tgggagactt cctgtctgcc actggacaga
     3001 gttcacagga gaccagggag gtagtccacg ggggatgagg gcttttccct ttcctcctca
     3061 gctggtaact cagggttcat ctgtccaagg cctttctaat aaacctacag tccagtcaaa
//
LOCUS       NM_012740               1763 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus tyrosine hydroxylase (Th), mRNA.
ACCESSION   NM_012740
VERSION     NM_012740.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Yamaguchi,H., Hara,S., Ichinose,H., Nagasaki,H. and Nakashima,A.
  TITLE     Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the
            analysis of NT5DC2-binding proteins
  JOURNAL   Biochem Biophys Res Commun 703, 149698 (2024)
   PUBMED   38382359
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Zhang,Y., Tsai,T.H., Ezrokhi,M., Stoelzel,C. and Cincotta,A.H.
  TITLE     Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary
            Nucleus Area Induces Obesity and Glucose Intolerance
  JOURNAL   Neuroendocrinology 114 (5), 483-510 (2024)
   PUBMED   38128505
  REMARK    GeneRIF: Tyrosine Hydroxylase Knockdown at the Hypothalamic
            Supramammillary Nucleus Area Induces Obesity and Glucose
            Intolerance.
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Leem,K.H., Kim,S., Kim,H.W. and Park,H.J.
  TITLE     Downregulation of microRNA-330-5p induces manic-like behaviors in
            REM sleep-deprived rats by enhancing tyrosine hydroxylase
            expression
  JOURNAL   CNS Neurosci Ther 29 (6), 1525-1536 (2023)
   PUBMED   36794530
  REMARK    GeneRIF: Downregulation of microRNA-330-5p induces manic-like
            behaviors in REM sleep-deprived rats by enhancing tyrosine
            hydroxylase expression.
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Cassinotti,L., Guil,M., Bianciotti,L. and Vatta,M.
  TITLE     Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of
            Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt
            Hypertensive Rats
  JOURNAL   Curr Vasc Pharmacol 21 (4), 246-256 (2023)
   PUBMED   37349999
  REMARK    GeneRIF: Role of Brain Endothelin Receptor Type B (ETB) in the
            Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of
            DOCA-Salt Hypertensive Rats.
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Jimenez,A., Herrera-Gonzalez,A., Organista-Juarez,D., Estudillo,E.,
            Velasco,I., Guerrero-Vargas,N.N., Guzman-Ruiz,M.A. and
            Guevara-Guzman,R.
  TITLE     Diabetes Induces Permanent Deleterious Effects in the Olfactory
            Bulb Associated with Increased Tyrosine Hydroxylase Expression and
            ERK1/2 Phosphorylation
  JOURNAL   ACS Chem Neurosci 13 (19), 2821-2828 (2022)
   PUBMED   36122168
  REMARK    GeneRIF: Diabetes Induces Permanent Deleterious Effects in the
            Olfactory Bulb Associated with Increased Tyrosine Hydroxylase
            Expression and ERK1/2 Phosphorylation.
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Haycock,J.W. and Haycock,D.A.
  TITLE     Tyrosine hydroxylase in rat brain dopaminergic nerve terminals.
            Multiple-site phosphorylation in vivo and in synaptosomes
  JOURNAL   J Biol Chem 266 (9), 5650-5657 (1991)
   PUBMED   1672315
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Wolff,J.A., Fisher,L.J., Xu,L., Jinnah,H.A., Langlais,P.J.,
            Iuvone,P.M., O'Malley,K.L., Rosenberg,M.B., Shimohama,S.,
            Friedmann,T. et al.
  TITLE     Grafting fibroblasts genetically modified to produce L-dopa in a
            rat model of Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 9011-9014 (1989)
   PUBMED   2573072
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Horellou,P., Guibert,B., Leviel,V. and Mallet,J.
  TITLE     A single RNA species injected in Xenopus oocyte directs the
            synthesis of active tyrosine hydroxylase
  JOURNAL   FEBS Lett 205 (1), 6-10 (1986)
   PUBMED   2427363
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Grima,B., Lamouroux,A., Blanot,F., Biguet,N.F. and Mallet,J.
  TITLE     Complete coding sequence of rat tyrosine hydroxylase mRNA
  JOURNAL   Proc Natl Acad Sci U S A 82 (2), 617-621 (1985)
   PUBMED   2857492
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Joh,T.H., Park,D.H. and Reis,D.J.
  TITLE     Direct phosphorylation of brain tyrosine hydroxylase by cyclic
            AMP-dependent protein kinase: mechanism of enzyme activation
  JOURNAL   Proc Natl Acad Sci U S A 75 (10), 4744-4748 (1978)
   PUBMED   33381
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012740.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M10244.1, SRR26360194.681303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000001.1  207508118-207508218 c
            102-326             JAXUCZ010000001.1  207506075-207506299 c
            327-501             JAXUCZ010000001.1  207505030-207505204 c
            502-590             JAXUCZ010000001.1  207504680-207504768 c
            591-658             JAXUCZ010000001.1  207504497-207504564 c
            659-709             JAXUCZ010000001.1  207504177-207504227 c
            710-855             JAXUCZ010000001.1  207503687-207503832 c
            856-991             JAXUCZ010000001.1  207503481-207503616 c
            992-1061            JAXUCZ010000001.1  207503253-207503322 c
            1062-1118           JAXUCZ010000001.1  207502806-207502862 c
            1119-1214           JAXUCZ010000001.1  207502572-207502667 c
            1215-1348           JAXUCZ010000001.1  207502185-207502318 c
            1349-1763           JAXUCZ010000001.1  207500965-207501379 c
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1763
                     /gene="Th"
                     /gene_synonym="The"
                     /note="tyrosine hydroxylase"
                     /db_xref="GeneID:25085"
                     /db_xref="RGD:3853"
     exon            1..101
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1508
                     /gene="Th"
                     /gene_synonym="The"
                     /EC_number="1.14.16.2"
                     /note="tyrosine 3-hydroxylase"
                     /codon_start=1
                     /product="tyrosine 3-monooxygenase"
                     /protein_id="NP_036872.1"
                     /db_xref="GeneID:25085"
                     /db_xref="RGD:3853"
                     /translation="MPTPSAPSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIED
                     ARKEREAAAAAAAAAVASSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVK
                     VFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAR
                     EDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGE
                     PIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDV
                     SRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
                     GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAG
                     LLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYAS
                     RIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAIS"
     misc_feature    12..104
                     /gene="Th"
                     /gene_synonym="The"
                     /note="propagated from UniProtKB/Swiss-Prot (P04177.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    15..89
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Tyrosine hydroxylase N terminal; Region: TOH_N;
                     pfam12549"
                     /db_xref="CDD:403668"
     misc_feature    15..89
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Tyrosine hydroxylase N terminal; Region: TOH_N;
                     pfam12549"
                     /db_xref="CDD:403668"
     misc_feature    66..68
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Phosphoserine, by CaMK2.
                     /evidence=ECO:0000269|PubMed:11502746,
                     ECO:0000269|PubMed:1672315, ECO:0000269|PubMed:21392500,
                     ECO:0000269|PubMed:32778969, ECO:0000269|PubMed:38382359;
                     propagated from UniProtKB/Swiss-Prot (P04177.3);
                     phosphorylation site"
     misc_feature    102..104
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1672315,
                     ECO:0000269|PubMed:21392500, ECO:0000269|PubMed:32778969,
                     ECO:0000269|PubMed:38382359; propagated from
                     UniProtKB/Swiss-Prot (P04177.3); phosphorylation site"
     misc_feature    123..485
                     /gene="Th"
                     /gene_synonym="The"
                     /note="ACT domain of the nonheme iron-dependent aromatic
                     amino acid hydroxylase, tyrosine hydroxylases (TH);
                     Region: ACT_TH; cd04930"
                     /db_xref="CDD:153202"
     misc_feature    123..485
                     /gene="Th"
                     /gene_synonym="The"
                     /note="ACT domain of the nonheme iron-dependent aromatic
                     amino acid hydroxylase, tyrosine hydroxylases (TH);
                     Region: ACT_TH; cd04930"
                     /db_xref="CDD:153202"
     misc_feature    129..131
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Phosphoserine, by CaMK2 and PKA.
                     /evidence=ECO:0000269|PubMed:11502746,
                     ECO:0000269|PubMed:1672315, ECO:0000269|PubMed:21392500,
                     ECO:0000269|PubMed:32778969, ECO:0000269|PubMed:38382359;
                     propagated from UniProtKB/Swiss-Prot (P04177.3);
                     phosphorylation site"
     misc_feature    order(294..305,354..365)
                     /gene="Th"
                     /gene_synonym="The"
                     /note="putative amino acid binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:153202"
     misc_feature    order(294..305,354..365)
                     /gene="Th"
                     /gene_synonym="The"
                     /note="putative amino acid binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:153202"
     misc_feature    504..1496
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Biopterin-dependent aromatic amino acid
                     hydroxylase; Region: Biopterin_H; pfam00351"
                     /db_xref="CDD:459776"
     misc_feature    504..1496
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Biopterin-dependent aromatic amino acid
                     hydroxylase; Region: Biopterin_H; pfam00351"
                     /db_xref="CDD:459776"
     misc_feature    1284..1286
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Important for substrate specificity.
                     /evidence=ECO:0000269|PubMed:10933781; propagated from
                     UniProtKB/Swiss-Prot (P04177.3); other site"
     misc_feature    1425..1427
                     /gene="Th"
                     /gene_synonym="The"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P24529; propagated from
                     UniProtKB/Swiss-Prot (P04177.3); phosphorylation site"
     exon            102..326
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            327..501
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            502..590
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            591..658
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            659..709
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            710..855
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            856..991
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1061
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1118
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1214
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1348
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1763
                     /gene="Th"
                     /gene_synonym="The"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcttgcac tatgcccacc cccagcgccc cctcgccaca gcccaagggc ttcagaaggg
       61 ccgtctcaga gcaggatgcc aagcaggccg aggctgtcac gtccccaagg ttcatcggac
      121 ggcgacagag tctcatcgag gatgcccgca aggagcggga ggcggcggca gctgcagcag
      181 cagcagcggt agcctcctcg gaacctggga acccactgga ggctgtggta tttgaggaga
      241 gggatgggaa tgctgttctc aacctgctct tctccctgag gggtacaaaa ccctcctcct
      301 tgtctcgggc tgtaaaagta tttgagacat ttgaagccaa aattcaccac ttagagaccc
      361 ggcctgccca gaggccactg gcaggaagcc cccacctgga gtattttgtg cgcttcgagg
      421 tgcccagtgg agacctggct gccctcctca gctctgtgcg tcgggtgtct gacgacgtgc
      481 gcagtgctag agaggacaag gtcccctggt tcccaagaaa agtgtcggaa ttggacaagt
      541 gtcaccacct ggtcaccaag tttgaccctg atctggacct ggaccacccg ggcttctctg
      601 accaggtgta tcgccagcgt cggaagctga ttgcagagat tgccttccag tacaagcacg
      661 gtgaaccaat tccccatgtg gaatacacag cggaagagat tgctacctgg aaggaggtat
      721 atgtcacgct gaagggcctc tatgctaccc atgcctgccg ggagcacctg gagggtttcc
      781 agcttctgga acggtactgt ggctaccgag aggacagcat cccacagctg gaggacgtgt
      841 cccgcttctt gaaggagcgg actggcttcc agctgcgacc cgtggccggt ctactgtccg
      901 cccgtgattt tctggccagt ctggccttcc gcgtgtttca atgcacccag tatatccgcc
      961 atgcctcctc acctatgcat tcacctgagc cggactgctg ccatgagctg ttgggacatg
     1021 tacccatgtt ggctgaccgc acatttgccc agttctccca ggacattgga cttgcatctc
     1081 tgggggcctc agatgaagaa attgaaaaac tctccacggt gtactggttc actgtggaat
     1141 tcgggctatg taaacagaat ggggagctga aggcttatgg tgcagggctg ctgtcttcct
     1201 acggagagct cctgcactcc ctgtcagagg agcctgaggt ccgagccttt gacccagaca
     1261 cagcagctgt gcagccctac caagatcaaa cctaccagcc tgtgtacttt gtgtccgaga
     1321 gcttcaatga cgccaaggac aagctcagga actatgcctc tcgtatccag cgcccattct
     1381 ctgtgaagtt tgacccgtac acactggcca ttgacgtact ggacagccct cacaccatcc
     1441 agcgctcctt ggagggggtc caggatgagc tgcacaccct ggcccacgca ctgagtgcca
     1501 ttagctaaat gcatagggta ccacccacag gtgccagggg cctttcccaa agtctccatc
     1561 cccttctcca acctttcctg gcccagaggc tttcccatgt gtgtggctgg gccctttgat
     1621 gggctcctct tggaccccca tcctcccaac actgcttctc aaccatgtct tactactgca
     1681 tgcactccag ggtggtcctg cattcctcct gccctccatg ctctatacta ccctgattat
     1741 tctctcaata aaggaaggaa aga
//
LOCUS       NM_001427033            5468 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 10
            (Arhgef10), mRNA.
ACCESSION   NM_001427033 XM_002728436
VERSION     NM_001427033.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5468)
  AUTHORS   Haaland,O.A., Romanowska,J., Gjerdevik,M., Lie,R.T., Gjessing,H.K.
            and Jugessur,A.
  TITLE     A genome-wide scan of cleft lip triads identifies parent-of-origin
            interaction effects between ANK3 and maternal smoking, and between
            ARHGEF10 and alcohol consumption
  JOURNAL   F1000Res 8, 960 (2019)
   PUBMED   31372216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5468)
  AUTHORS   Matsushita,T., Ashikawa,K., Yonemoto,K., Hirakawa,Y., Hata,J.,
            Amitani,H., Doi,Y., Ninomiya,T., Kitazono,T., Ibayashi,S., Iida,M.,
            Nakamura,Y., Kiyohara,Y. and Kubo,M.
  TITLE     Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke
  JOURNAL   Hum Mol Genet 19 (6), 1137-1146 (2010)
   PUBMED   20042462
REFERENCE   3  (bases 1 to 5468)
  AUTHORS   Aoki,T., Ueda,S., Kataoka,T. and Satoh,T.
  TITLE     Regulation of mitotic spindle formation by the RhoA guanine
            nucleotide exchange factor ARHGEF10
  JOURNAL   BMC Cell Biol 10, 56 (2009)
   PUBMED   19635168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5468)
  AUTHORS   Mohl,M., Winkler,S., Wieland,T. and Lutz,S.
  TITLE     Gef10--the third member of a Rho-specific guanine nucleotide
            exchange factor subfamily with unusual protein architecture
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 373 (5), 333-341 (2006)
   PUBMED   16896804
REFERENCE   5  (bases 1 to 5468)
  AUTHORS   Verhoeven,K., De Jonghe,P., Van de Putte,T., Nelis,E., Zwijsen,A.,
            Verpoorten,N., De Vriendt,E., Jacobs,A., Van Gerwen,V., Francis,A.,
            Ceuterick,C., Huylebroeck,D. and Timmerman,V.
  TITLE     Slowed conduction and thin myelination of peripheral nerves
            associated with mutant rho Guanine-nucleotide exchange factor 10
  JOURNAL   Am J Hum Genet 73 (4), 926-932 (2003)
   PUBMED   14508709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 9, 2024 this sequence version replaced XM_002728436.6.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000016.1  81440010-81440054   c
            46-216              JAXUCZ010000016.1  81425394-81425564   c
            217-483             JAXUCZ010000016.1  81420858-81421124   c
            484-765             JAXUCZ010000016.1  81419646-81419927   c
            766-829             JAXUCZ010000016.1  81417010-81417073   c
            830-906             JAXUCZ010000016.1  81414385-81414461   c
            907-963             JAXUCZ010000016.1  81412462-81412518   c
            964-1127            JAXUCZ010000016.1  81407731-81407894   c
            1128-1235           JAXUCZ010000016.1  81405455-81405562   c
            1236-1350           JAXUCZ010000016.1  81403025-81403139   c
            1351-1457           JAXUCZ010000016.1  81400790-81400896   c
            1458-1535           JAXUCZ010000016.1  81395623-81395700   c
            1536-1715           JAXUCZ010000016.1  81395235-81395414   c
            1716-1832           JAXUCZ010000016.1  81393027-81393143   c
            1833-1925           JAXUCZ010000016.1  81391416-81391508   c
            1926-2096           JAXUCZ010000016.1  81388925-81389095   c
            2097-2242           JAXUCZ010000016.1  81387382-81387527   c
            2243-2418           JAXUCZ010000016.1  81386313-81386488   c
            2419-2534           JAXUCZ010000016.1  81376069-81376184   c
            2535-2662           JAXUCZ010000016.1  81375514-81375641   c
            2663-2763           JAXUCZ010000016.1  81375272-81375372   c
            2764-2885           JAXUCZ010000016.1  81373604-81373725   c
            2886-2972           JAXUCZ010000016.1  81372783-81372869   c
            2973-3199           JAXUCZ010000016.1  81371349-81371575   c
            3200-3357           JAXUCZ010000016.1  81370635-81370792   c
            3358-3500           JAXUCZ010000016.1  81366627-81366769   c
            3501-3675           JAXUCZ010000016.1  81358952-81359126   c
            3676-3798           JAXUCZ010000016.1  81353002-81353124   c
            3799-5468           JAXUCZ010000016.1  81349429-81351098   c
FEATURES             Location/Qualifiers
     source          1..5468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..5468
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="Rho guanine nucleotide exchange factor 10"
                     /db_xref="GeneID:306618"
                     /db_xref="RGD:1565043"
     exon            1..45
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            46..216
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    54..56
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="upstream in-frame stop codon"
     CDS             180..4301
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="Rho guanine nucleotide exchange factor (GEF) 10"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 10"
                     /protein_id="NP_001413962.1"
                     /db_xref="GeneID:306618"
                     /db_xref="RGD:1565043"
                     /translation="MDQGEASPPVPAEHEVKCDTSNNEEEGELFDFESGDEVPEADRQ
                     APTADDGTGVAEADGADENTSPDGTGVAEADGADENTSPDGTRVDEADGADENTSPAG
                     NGTGAESVPEAEPEKLVVPIKVNPYSVIDITPFQEDQPPSPDANPEEEGVGLRVPSGY
                     CVPVPCGYAVPSNLPLLLPTYSSQIIIRAQSVEEEVAAEVAGDGQCNSLSSEDLPHSG
                     DQGSQEGSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGGEGG
                     NSSLEYGWSSSEFESYEEPSDSEGKNGIPRSFLRSNHKKQLSHDLTRFKAHCEEKMRG
                     LVASTVGAMEAQQRQEWKMQRLMKAAKEGTRDGLEKTKAAVKRGRSFIRTKSLVSQDH
                     RYYFEEEQNLFIDVDCKHPEAVLTPMPEGLSQQQVVRRYILGSIVESEKNYVDALRRI
                     LEQYEKPLSEMEPRLLSDRKLRMVFYRIKEILQCHSMFQIALASRVSEWDAVETIGDV
                     FVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKLSQDSSPDRVTLHSL
                     MMRPIQRFPQFILLLQDMLKNTAKGHPDRLPLQMALTELETLAEKLNERKRDADQRCE
                     IKQIAKAINERYLNKLLSSGNRYLVRSDDVIETVYNDRGEIVKTKQRRIFMLNDVLMC
                     ATASSRNSHESHAMMNQRYLLKWSVPLGQVDVIEYSGSSGTGDHSRHHTAHSPESLAV
                     VANVKPHKVYMGPGQLYQDLQNLLHDLNVVGQISQLIGNLRGSYQNLNQSVAHDWTSG
                     LQQLILRKEDAIRAADRCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVSSLQM
                     AKLALEEENHMGWFCVDDDGSLAKKETHPLLVGHTSVMVAKQPEFKIECAAYNPEPYP
                     SNDNQPASPSTARGFLWIGSCSNQMGQVAIVSFQSANPKVIECFNVESRILCMIYIPA
                     EESKPQEPADTKDPEATASRAPHVPTICLGTEEGSISIYKSSQGCKKVRLQHFYTPDK
                     STVMSLACSPHGLYAGLVNGSVASYTKAPDGSWNSEPQQVIKLGVLPVRSLLLVEGAL
                     WAASGGQVFMASVETHTVENQLEAHQDEGMVISHMAVAGVGIWIAFTSGSTLRLFHTE
                     TLKHLQDVNIDAPVHSMLPGHQRLSVTSLLVCHGLLMVGTSLGVVVALPVPRLQGIPK
                     VTGRGMVSYHAHNGPVKFIVTATAFQNKDRARDRPRSSSELQDEDPKDLLCGEEGTSC
                     LGQTDTSTAVWLGDSLGLTAQNDLSSSSGSLSHGSSSLEHRSVDSSLCDLLRDPSAFP
                     RSRAQSSRRARASSALVVCGGQGHRRVHRKARQPSQEDLVSSVMVWQIPLLGM"
     misc_feature    <183..>521
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    <183..>521
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    1464..2018
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
                     /db_xref="CDD:238091"
     misc_feature    1464..2018
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
                     /db_xref="CDD:238091"
     misc_feature    order(1482..1484,1494..1496,1788..1790,1869..1874,
                     1881..1886,1890..1895,1902..1907,1914..1919,1926..1928,
                     2004..2006,2016..2018)
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238091"
     misc_feature    order(1482..1484,1494..1496,1788..1790,1869..1874,
                     1881..1886,1890..1895,1902..1907,1914..1919,1926..1928,
                     2004..2006,2016..2018)
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238091"
     misc_feature    2085..2534
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="PH domain; Region: PH_19; pfam19057"
                     /db_xref="CDD:465965"
     misc_feature    2085..2534
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="PH domain; Region: PH_19; pfam19057"
                     /db_xref="CDD:465965"
     misc_feature    2856..4292
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="WD40 repeated domain; Region: WD40_2; pfam19056"
                     /db_xref="CDD:465964"
     misc_feature    2856..4292
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /note="WD40 repeated domain; Region: WD40_2; pfam19056"
                     /db_xref="CDD:465964"
     exon            217..483
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            484..765
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            766..829
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            830..906
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            907..963
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1127
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1235
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1350
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1457
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1535
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1715
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1832
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1925
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2096
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2242
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2418
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2534
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2662
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2763
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2885
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2972
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3199
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3357
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3500
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3675
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3798
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..5468
                     /gene="Arhgef10"
                     /gene_synonym="RGD1565043"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacaactg gcggacgcag acggcggatg gcgcccggcc cctcggttgc ctctagaaag
       61 ccccgactgg cgtctcctgg gaaggtttca tatgccaact tgagggacaa tgtctgtgcc
      121 tgcaggggcc cctgtcccct gatgctgtcc acgtgtggag gaaggaggca aggctgagca
      181 tggaccaggg agaggcctca ccacctgtgc ctgcagaaca cgaggtgaaa tgtgacacca
      241 gcaacaatga ggaggaggga gagctgtttg actttgagag tggagatgaa gtcccggaag
      301 ccgaccgaca ggccccgact gccgatgacg ggacgggagt tgctgaagca gacggtgcag
      361 atgagaacac gtcccctgac gggacgggag ttgctgaagc agacggtgca gatgagaaca
      421 cgtcccctga tgggacgaga gttgatgaag cagacggtgc agatgagaac acgtcccctg
      481 caggaaacgg aactggagcg gaatctgtcc ctgaggcaga gcctgagaaa cttgtggtcc
      541 caataaaagt gaacccatat tctgtcattg acatcacgcc gttccaggag gaccagccgc
      601 catctccaga tgcaaaccca gaggaggaag gggtgggcct gcgcgtgccc agtggttact
      661 gtgtgcctgt gccctgtggc tacgctgtcc catctaacct gccgttgctg ctgcccacct
      721 actccagcca aatcatcatc cgagcccagt ctgtagagga ggaagttgca gcagaagttg
      781 cgggagacgg gcagtgcaat tccctaagtt ctgaggacct accacacagc ggtgatcaag
      841 gcagccaaga aggcagtgcc ctggcccgat gggcagccga ccctgccaac acagcctgga
      901 tggaaaatcc agaggaagca atttacgatg atgttccaag ggaaaactca gactctgaac
      961 cagatgaaat gatttacgat gacgtggaga acggaggcga gggtggaaac agctccctgg
     1021 agtacgggtg gagctccagc gagtttgaaa gctacgagga gccaagcgac tcggagggca
     1081 agaacgggat tcccaggtcc ttcctacgca gcaaccataa aaagcaactc tctcatgacc
     1141 taacccgctt taaggcgcac tgtgaggaaa agatgagagg tttggtggcc agtacggtgg
     1201 gagccatgga ggcacagcag aggcaggagt ggaagatgca gagacttatg aaggcagcca
     1261 aggagggcac cagagatggt ttggagaaga ccaaggctgc cgtgaagaga ggccgctcct
     1321 tcatcaggac caagtccttg gtctctcaag atcacaggta ttattttgaa gaagagcaga
     1381 atttgttcat tgatgttgac tgcaagcacc cggaggctgt cctcactcca atgcccgagg
     1441 gtctgtctca gcagcaggtt gtgaggagat acattctggg ctccattgtt gagagtgaga
     1501 agaactacgt agatgctctc cggcggattt tggagcaata tgagaagcca ctgtccgaga
     1561 tggagccccg gctcctgagt gacaggaagc tcaggatggt attttaccgc atcaaagaga
     1621 tcctgcagtg tcattccatg ttccagatcg cactggccag ccgggtgtct gagtgggatg
     1681 ccgtggaaac aatcggagat gttttcgtgg cctcgttctc caagtccatg gtgctggatg
     1741 cttacagcga gtatgtgaac aacttcagca cggccgtggc tgtcctcaag aagacgtgtg
     1801 ccacaaagcc tgccttcctt gagttcttaa agctgagcca ggattccagt ccagaccgag
     1861 tcacactcca cagccttatg atgcggccca tccagcggtt cccacagttc atcctcctgc
     1921 tgcaggacat gctgaagaac acagccaaag gacaccctga caggctgccc cttcagatgg
     1981 cgctgacgga gctcgagacc ctggcggaga agctaaacga gagaaagaga gatgctgacc
     2041 agcggtgtga aatcaagcaa atagcaaaag ccataaacga aagatacctg aacaagctcc
     2101 tcagcagtgg gaaccggtac ctcgttcgct ccgatgacgt cattgagacg gtttacaacg
     2161 accggggaga aatcgtcaag accaagcagc gccggatctt tatgctgaat gacgtgctga
     2221 tgtgtgctac cgccagctca cggaactcac atgaaagcca tgccatgatg aaccagaggt
     2281 acctgctcaa gtggagcgtc cctctaggac aggtggacgt gatcgagtac agcggcagtt
     2341 ctggcacggg ggatcacagc cggcaccaca ctgcacactc accggagagc ctggccgtgg
     2401 tggccaatgt gaagccgcac aaagtttaca tggggccagg gcagctgtac caggatctgc
     2461 agaacctact gcacgacctg aatgttgtcg gccagatctc gcagctgata ggaaacctcc
     2521 gggggagcta tcagaactta aaccagtcag tagcccacga ctggacgtct ggcttacagc
     2581 agctgatcct gaggaaagaa gatgcgatca gagccgccga ccgctgcagg attcagttac
     2641 agctcccggg aaagcaggac aagtcagggc ggcccacatt cttcaccgct gtgttcaata
     2701 cgtttacccc cgccatcaag gagtcctggg tcagcagcct gcagatggcc aagctggccc
     2761 ttgaggagga aaaccatatg ggatggttct gtgtggatga cgatggcagc ctcgccaaga
     2821 aagagacaca ccctctcctg gtgggacaca cgtctgtgat ggtggccaag cagccagagt
     2881 tcaagatcga atgtgcagct tataaccccg agccttaccc aagcaacgat aaccaaccag
     2941 cgtcaccctc cacggcgcgt ggcttcctgt ggatcggaag ctgcagcaat cagatgggtc
     3001 aggtcgccat tgtctccttc caaagtgcca accccaaagt catcgagtgc ttcaatgtgg
     3061 agtcacgcat cctgtgtatg atttacatcc cggcggagga gtcaaagccc caagagcccg
     3121 ctgacaccaa ggacccagag gccacagcgt cgagagcacc ccacgtgccc accatctgcc
     3181 tgggcacaga ggagggaagc atttccattt acaaaagcag tcagggctgc aagaaggtga
     3241 ggctccagca cttctacacg cctgacaagt ccacagtcat gagcttggcc tgctccccgc
     3301 acggcctgta tgcaggcctg gtcaatgggt ctgtagccag ctacaccaag gctccagatg
     3361 gatcctggaa ctcggaaccc cagcaagtga tcaagttggg tgtcctgcca gtcagaagcc
     3421 ttctcctggt ggagggcgcg ctgtgggcag cctcgggagg gcaggtgttc atggccagcg
     3481 tggagactca caccgtagag aatcagctgg aggcccacca agacgagggg atggtcatct
     3541 cccacatggc tgtggctggg gtcggcattt ggattgcctt cacctcgggg tccacgcttc
     3601 gcctcttcca cacagagacc ttgaagcacc tgcaggatgt caacatcgac gcccccgtgc
     3661 atagcatgtt gccagggcac cagcgtctgt ctgtgaccag cctgctcgtc tgccatggcc
     3721 tgctcatggt tggtaccagc ctgggtgttg tagtggccct gccagtccct cggcttcagg
     3781 gtatccccaa agtgacaggg cgaggcatgg tctcctacca tgcgcataat gggcccgtta
     3841 agttcattgt cacagccaca gcgtttcaga acaaggacag agcccgggac agaccacgtt
     3901 ccagttctga gcttcaggac gaagacccca aggacttgct ctgcggtgag gagggcactt
     3961 cttgcctggg ccagactgac accagcacag cggtttggtt gggagactcc ctaggattga
     4021 cagctcagaa cgacctgtct tcatcgtcgg ggtcactgtc ccatggctcc agctccctag
     4081 agcacagatc tgtggacagc agcctgtgtg acctcctgag ggaccccagt gcctttccaa
     4141 ggagcagggc acagagctct aggagagcca gagccagttc agcgctggtg gtatgtgggg
     4201 gccagggcca ccggcgggtg cacaggaagg ccaggcagcc ttctcaggag gacctggttt
     4261 cttcggtgat ggtgtggcag attccactgc tgggcatgta ggtcagaggt cagaggcagc
     4321 tgcctggcat caggtggcga gcaaggacaa ctctcagctg gatgcagacc gactgacagg
     4381 cagcatccat actcactggg accaactgga aaggaagtgt gcagcggtca cacagctccc
     4441 gtgcctcgtg tgctggggac gcagagcagc attctggctc ttgggtccct gagcaacgtt
     4501 ccaggataat gttacagtcc gccccgtcat tcacctgaga cgccaagtga gccgtctgtg
     4561 tgagttccag tcacatctca gagaactgac ggggaactgt agcatctact agcataggag
     4621 gccgttaaca attcttaaaa tcattctact tgactcaacc tcgctaccat tatttatatt
     4681 ctatatattt ttaaaattcc agagtacaga ttgtaacaat ttggaaagcc aggtaacaca
     4741 cccaagtcca gtcagcttgg tattttgtgg gggagcaact gaggctttcc aaagtagact
     4801 tttatgtgta ctgtcccctc taacaaatac tctttttata ttgcattttt ttctattaaa
     4861 aatcaacagc taacatttag tcaatgtcct atctgtagcg tttcacgtgt aatctttaag
     4921 ccaaaatgtt cagtacctat caagttttga ggtccagctt ccacactgta cttgccctat
     4981 ctgcgtggga caggtgctgg cccagtcgtg cagggatggt gctagtcgag tcttgggtct
     5041 tctgggcacc tgctgtcagg gagccatcgc agttggacac tccttctgag tggttcgtgg
     5101 tgctgatcag tcagccgcta cccccactgc ctgctgtccc agtgccaccc cccttcccaa
     5161 agaatgcaca gggtcatgtg ggacacttga gaagcagccg cggatgtcaa ggggtatgag
     5221 tagcccatag actccctttg ctccacctgt atttatacat cagcgtctca ctggatggtt
     5281 aaaaaaaaat tttttttaaa cctaatgcag atattcacca ggaacaactt ctcagcactt
     5341 tacaaaggac taaaatgcta actttttacc ttagccaaat actgtctaaa ttgcacatat
     5401 acccagcctt tcttaaactg ttagctgcta tctcgtttga taaaaataaa agactttatt
     5461 ttagaata
//
LOCUS       NM_001082479            1827 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus insulin-like growth factor 1 (Igf1), transcript
            variant 4, mRNA.
ACCESSION   NM_001082479
VERSION     NM_001082479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Xiong,J., Wang,Y., Wang,H., Luo,J., Chen,T., Sun,J., Xi,Q. and
            Zhang,Y.
  TITLE     GHRH-stimulated pituitary small extracellular vesicles inhibit
            hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p
  JOURNAL   J Nanobiotechnology 22 (1), 649 (2024)
   PUBMED   39438882
  REMARK    GeneRIF: GHRH-stimulated pituitary small extracellular vesicles
            inhibit hepatocyte proliferation and IGF-1 expression by its cargo
            miR-375-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Maleki,A.H., Azar,J.T., Razi,M. and Tofighi,A.
  TITLE     The Effect of Different Exercise Modalities on Sertoli-germ Cells
            Metabolic Interactions in High-fat Diet-induced Obesity Rat Models:
            Implication on Glucose and Lactate Transport, Igf1, and
            Igf1R-dependent Pathways
  JOURNAL   Reprod Sci 31 (8), 2246-2260 (2024)
   PUBMED   38632221
  REMARK    GeneRIF: The Effect of Different Exercise Modalities on
            Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced
            Obesity Rat Models: Implication on Glucose and Lactate Transport,
            Igf1, and Igf1R-dependent Pathways.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Barik,P., Kuo,W.W., Kuo,C.H., Hsieh,D.J., Day,C.H., Daddam,J.,
            Chen,M.Y., Padma,V.V., Shibu,M.A. and Huang,C.Y.
  TITLE     Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by
            co-chaperone carboxyl-terminus of Hsp70 interacting protein in
            adipose-derived stem cells provide augmented cardioprotection in
            aging-hypertensive rats
  JOURNAL   Aging (Albany NY) 15 (23), 14019-14038 (2023)
   PUBMED   38085649
  REMARK    GeneRIF: Rewiring of IGF1 secretion and enhanced IGF1R signaling
            induced by co-chaperone carboxyl-terminus of Hsp70 interacting
            protein in adipose-derived stem cells provide augmented
            cardioprotection in aging-hypertensive rats.
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Zhao,H., Wang,L., Yan,Y., Zhao,Q.H., He,J., Jiang,R., Luo,C.J.,
            Qiu,H.L., Miao,Y.Q., Gong,S.G., Yuan,P. and Wu,W.H.
  TITLE     Identification of the shared gene signatures between pulmonary
            fibrosis and pulmonary hypertension using bioinformatics analysis
  JOURNAL   Front Immunol 14, 1197752 (2023)
   PUBMED   37731513
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Nanto-Salonen,K. and Rosenfeld,R.G.
  TITLE     Insulin-like growth factor binding protein expression in the
            hypothyroid rat is age dependent
  JOURNAL   Endocrinology 131 (3), 1489-1496 (1992)
   PUBMED   1380443
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Hall,L.J., Kajimoto,Y., Bichell,D., Kim,S.W., James,P.L.,
            Counts,D., Nixon,L.J., Tobin,G. and Rotwein,P.
  TITLE     Functional analysis of the rat insulin-like growth factor I gene
            and identification of an IGF-I gene promoter
  JOURNAL   DNA Cell Biol 11 (4), 301-313 (1992)
   PUBMED   1605853
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Nanto-Salonen,K., Glasscock,G.F. and Rosenfeld,R.G.
  TITLE     The effects of thyroid hormone on insulin-like growth factor (IGF)
            and IGF-binding protein (IGFBP) expression in the neonatal rat:
            prolonged high expression of IGFBP-2 in methimazole-induced
            congenital hypothyroidism
  JOURNAL   Endocrinology 129 (5), 2563-2570 (1991)
   PUBMED   1718729
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Kato,H., Okoshi,A., Miura,Y. and Noguchi,T.
  TITLE     A new cDNA clone relating to larger molecular species of rat
            insulin-like growth factor-I mRNA
  JOURNAL   Agric Biol Chem 54 (6), 1599-1601 (1990)
   PUBMED   1368571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB751206.1, BC086374.1 and CB761687.1.
            
            Transcript Variant: This variant (4) lacks an alternate
            frame-shifting exon in the 3' coding region, compared to variant 3,
            resulting in a protein (isoform d) with a novel C-terminus,
            compared to isoform c. This isoform is also known as IA.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17335.1, CF108511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               CB751206.1         48-390
            344-948             BC086374.1         47-651
            949-1688            BC086374.1         653-1392
            1689-1827           CB761687.1         291-429
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1827
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin-like growth factor 1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
     exon            1..343
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    197..199
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="upstream in-frame stop codon"
     CDS             281..742
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="isoform d preproprotein is encoded by transcript
                     variant 4; somatomedin; IGF-I; Insulin-like growth factor
                     I"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform d
                     preproprotein"
                     /protein_id="NP_001075948.1"
                     /db_xref="GeneID:24482"
                     /db_xref="RGD:2868"
                     /translation="MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPTKSARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM"
     sig_peptide     281..424
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     proprotein      425..739
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform d
                     proprotein"
     mat_peptide     425..634
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /product="insulin-like growth factor 1 isoform d"
     misc_feature    425..628
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    425..628
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="insulin_like growth factors; specific to
                     vertebrates. Members include a number of peptides
                     including insulin-like growth factors I and II, which play
                     a variety of roles in controlling processes such as
                     growth, differentiation, and reproduction. On a...;
                     Region: IlGF; cd04368"
                     /db_xref="CDD:239834"
     misc_feature    425..511
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: B"
     misc_feature    order(431..433,458..460,482..496)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(431..433,458..460,482..496)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="IGFBP binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(485..487,491..496,554..556)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(485..487,491..496,554..556)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 1 IGF- and insulin-receptor binding surface
                     [active]"
                     /db_xref="CDD:239834"
     misc_feature    512..547
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: C"
     misc_feature    548..610
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: A"
     misc_feature    order(569..577,587..592)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    order(569..577,587..592)
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="type 2 IGF-receptor binding surface [active]"
                     /db_xref="CDD:239834"
     misc_feature    611..634
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: D"
     misc_feature    635..739
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /note="propagated from UniProtKB/Swiss-Prot (P08025.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            344..500
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            501..682
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1827
                     /gene="Igf1"
                     /gene_synonym="IGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagggaga gagagagaag gcgaatgttc ccccagctgt ttcctgtcta cagtgtctgt
       61 gttttgtaga taaatgtgag gattttctct aaatccctct tctgcttgct aaatctcact
      121 gtcgctgcta aattcagagc agatagagcc tgcgcaatcg aaataaagtc ctcaaaattg
      181 aaatgtgact ttgctctaac atctcccatc tctctggatt tctttttgcc tcattattcc
      241 tgcccaccaa ttcatttcca gactttgtac ttcagaagcg atggggaaaa tcagcagtct
      301 tccaactcaa ttatttaaga tctgcctctg tgacttcttg aagataaaga tacacatcat
      361 gtcgtcttca catctcttct acctggcact ctgcttgctc acctttacca gctcggccac
      421 agccggacca gagacccttt gcggggctga gctggtggac gctcttcagt tcgtgtgtgg
      481 accaaggggc ttttacttca acaagcccac aggctatggc tccagcattc ggagggcacc
      541 acagacgggc attgtggatg agtgttgctt ccggagctgt gatctgagga ggctggagat
      601 gtactgtgct ccgctgaagc ctacaaagtc agctcgttcc atccgggccc agcgccacac
      661 tgacatgccc aagactcaga aggaagtaca cttgaagaac acaagtagag gaagtgcagg
      721 aaacaagacc tacagaatgt aggaggagcc tcccgaggaa cagaaaatgc cacgtcaccg
      781 caagatcctt tgctgcttga gcaacctgca aaacatcgga acacctgcca aatatcaata
      841 atgagttcaa taccatttca gagatgggca tttccctcaa tgaaatacac aagtaaacat
      901 tccgacattg tctttaggag tgtttgttaa aaaaaaaaaa aaaaaaaaca aaaacaaaaa
      961 caaaaaaaaa aagctttgca ccttgcaaaa gtggtcctgg cgtgggtaga ttgctgttaa
     1021 tcctttatca ataacgttct atagagaata tataaatata tatataatta tatctcctag
     1081 tccctgcctc ttaagagccg aaaatgcatg ggtgttgtag acattcggtt gcactaaatt
     1141 cctctctgaa ttttggctgc tgaagccgtt catttagcaa ctgtttatag gtggttgatg
     1201 aatggttcct tatctccatt tcttcctatg tagcttaagc cgcttccttc acagaatcta
     1261 ataatctcgt ctaggccatt agccctgccc tttcttaaca ttcttgtatt tgttgaattt
     1321 ggcctcctcg aaagcaatag caactgggtg gcccacccaa gttttaacgc ccctgattcc
     1381 atctatggca tttgtaccaa atataagttg gatgcattta ttttagacac aaagctttat
     1441 tttttcgaca tcgtgtttca agaaaaaaaa caaatagaat aacaataact atgactttga
     1501 ggccaatcat ttttaggtgt gtgtttgaag catagaacgt ctcttaaact ctcaatggtt
     1561 ccttcaaatg atgagttagt atgtaacgta aatagcagtt tctctctctc tctctctctt
     1621 tttatttttt ccatatagag cactatgtaa atttagcata tcaataatac aggaactatc
     1681 aaacagtatg taaactccgt tgttgttgtt tttagtacaa tggtgctatt ttgtagtttg
     1741 ttctatgaaa gaatctagtc aacacagaga aaggagaaag caaagcaaaa acaatgaaag
     1801 cctggagccc aaaaggacaa aattagg
//
LOCUS       NM_053664               4120 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus sarcosine dehydrogenase (Sardh), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_053664
VERSION     NM_053664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4120)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 4120)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   3  (bases 1 to 4120)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 4120)
  AUTHORS   Bergeron,F., Otto,A., Blache,P., Day,R., Denoroy,L., Brandsch,R.
            and Bataille,D.
  TITLE     Molecular cloning and tissue distribution of rat sarcosine
            dehydrogenase
  JOURNAL   Eur J Biochem 257 (3), 556-561 (1998)
   PUBMED   9839943
REFERENCE   5  (bases 1 to 4120)
  AUTHORS   Porter,D.H., Cook,R.J. and Wagner,C.
  TITLE     Enzymatic properties of dimethylglycine dehydrogenase and sarcosine
            dehydrogenase from rat liver
  JOURNAL   Arch Biochem Biophys 243 (2), 396-407 (1985)
   PUBMED   2417560
REFERENCE   6  (bases 1 to 4120)
  AUTHORS   Cook,R.J., Misono,K.S. and Wagner,C.
  TITLE     The amino acid sequences of the flavin-peptides of dimethylglycine
            dehydrogenase and sarcosine dehydrogenase from rat liver
            mitochondria
  JOURNAL   J Biol Chem 260 (24), 12998-13002 (1985)
   PUBMED   4055729
REFERENCE   7  (bases 1 to 4120)
  AUTHORS   Wittwer,A.J. and Wagner,C.
  TITLE     Identification of the folate-binding proteins of rat liver
            mitochondria as dimethylglycine dehydrogenase and sarcosine
            dehydrogenase. Flavoprotein nature and enzymatic properties of the
            purified proteins
  JOURNAL   J Biol Chem 256 (8), 4109-4115 (1981)
   PUBMED   6163778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 29, 2023 this sequence version replaced NM_053664.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067650.2, SRR26643286.9635.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000003.1  30971525-30971657   c
            134-488             JAXUCZ010000003.1  30968824-30969178   c
            489-667             JAXUCZ010000003.1  30967389-30967567   c
            668-847             JAXUCZ010000003.1  30966172-30966351   c
            848-971             JAXUCZ010000003.1  30962700-30962823   c
            972-1072            JAXUCZ010000003.1  30962452-30962552   c
            1073-1177           JAXUCZ010000003.1  30959047-30959151   c
            1178-1307           JAXUCZ010000003.1  30957866-30957995   c
            1308-1394           JAXUCZ010000003.1  30954163-30954249   c
            1395-1485           JAXUCZ010000003.1  30953836-30953926   c
            1486-1627           JAXUCZ010000003.1  30951736-30951877   c
            1628-1711           JAXUCZ010000003.1  30949484-30949567   c
            1712-1825           JAXUCZ010000003.1  30947283-30947396   c
            1826-1964           JAXUCZ010000003.1  30942955-30943093   c
            1965-2078           JAXUCZ010000003.1  30941162-30941275   c
            2079-2226           JAXUCZ010000003.1  30936272-30936419   c
            2227-2320           JAXUCZ010000003.1  30932290-30932383   c
            2321-2483           JAXUCZ010000003.1  30917468-30917630   c
            2484-2652           JAXUCZ010000003.1  30916574-30916742   c
            2653-2788           JAXUCZ010000003.1  30911991-30912126   c
            2789-4120           JAXUCZ010000003.1  30908621-30909952   c
FEATURES             Location/Qualifiers
     source          1..4120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..4120
                     /gene="Sardh"
                     /note="sarcosine dehydrogenase"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
     exon            1..133
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            134..488
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    146..148
                     /gene="Sardh"
                     /note="upstream in-frame stop codon"
     CDS             155..2914
                     /gene="Sardh"
                     /EC_number="1.5.8.3"
                     /codon_start=1
                     /product="sarcosine dehydrogenase, mitochondrial"
                     /protein_id="NP_446116.2"
                     /db_xref="GeneID:114123"
                     /db_xref="RGD:621125"
                     /translation="MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQC
                     TLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERL
                     TSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQ
                     QRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTC
                     TTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWA
                     SSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEA
                     NPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHK
                     PLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSL
                     TDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWER
                     PGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACR
                     TAAAVFNMSYFGKFYLLGADARKAADWLFSADVNRPPGSTVYTCMLNQRGGTESDLTV
                     SCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLG
                     MLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHV
                     PQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAF
                     TCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRA
                     DFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKR
                     VKGIY"
     transit_peptide 155..220
                     /gene="Sardh"
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q64380.2)"
     mat_peptide     221..2911
                     /gene="Sardh"
                     /product="Sarcosine dehydrogenase, mitochondrial.
                     /id=PRO_0000010772"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64380.2)"
     misc_feature    353..1489
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    353..1489
                     /gene="Sardh"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; Region: DadA; COG0665"
                     /db_xref="CDD:440429"
     misc_feature    674..676
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    1445..1612
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1445..1612
                     /gene="Sardh"
                     /note="FAD dependent oxidoreductase central domain;
                     Region: FAO_M; pfam16350"
                     /db_xref="CDD:465100"
     misc_feature    1595..2905
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1595..2905
                     /gene="Sardh"
                     /note="Glycine cleavage system protein T
                     (aminomethyltransferase) [Amino acid transport and
                     metabolism]; Region: GcvT; COG0404"
                     /db_xref="CDD:440173"
     misc_feature    1832..1834
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2480..2482
                     /gene="Sardh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2486..2488
                     /gene="Sardh"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UL12; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); phosphorylation site"
     misc_feature    2561..2563
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2807..2809
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     misc_feature    2867..2869
                     /gene="Sardh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LB7; propagated from
                     UniProtKB/Swiss-Prot (Q64380.2); acetylation site"
     exon            489..667
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            668..847
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            848..971
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1072
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1177
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1307
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1394
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1485
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1627
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1711
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1825
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1964
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2078
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2226
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2320
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2483
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2652
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2788
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..4120
                     /gene="Sardh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcctggc atggtgtcct gaggtagagg cactgcctgg acttgcagaa cctcgattgg
       61 gtccatatca tgctgacttt tccttgctag gaatctccca ggagcttctg gaaaatctag
      121 gacgaagact aaggtacagg agccctaagt ccccatggct tcactgagcc gggtcctccg
      181 tgtagctgcc acctgtcctc gagggagatc tgctcgcaac ctggggctac agcccctagc
      241 cagggaggcc aggcccacca ctgagaagag tgttccatac cagtgcaccc tgaaggagga
      301 ggcccaaggt gcctctgtgg tgccccaagg accaagccag cccctgccta gcacagccaa
      361 tgttgtggtc attggtgggg gcagtttggg ctgccagact ctgtaccact tggccaagct
      421 gggtgtaggt ggagttgtgc tgctggagag agagcgactg acctctggga ccacctggca
      481 cacagcaggc ctactgtggc agctgcggcc cagcgatgtg gaagtagagc ttctggctca
      541 cacacggcaa gtggtgagcc atgatctgga agaggagact gggcttcaca caggctggat
      601 ccagaatggt ggcctcttca tcgcctccaa ccagcagcgc ctggatgaat acaagaggct
      661 catgtcgttg ggcaaggcct acggtataga atcccatgtg ctgagccctg cagagaccaa
      721 ggatctgtat ccgctgatga atgtggacga cctctatggg accctgtatg tgcctcggga
      781 tggtaccatg gacccggctg gcacctgcac taccctcacc agagcagcag tggctagggg
      841 agctcaggtc attgaaaact gtgcagtgac tggcatccgt gtgcggacag acgactttgg
      901 agtgcggcgg gtgacagctg tggagactca acatggctcc atccagacac cctgcgtggt
      961 caactgtgca ggggtgtggg cgagctccgt gggccggatg gctggagtga aggtcccgct
     1021 ggtggccatg caccatgcct acgttgtcac tgagcgcatt gaggggatcc agaacatgcc
     1081 caatgtccgg gatcatgatg cttctgtcta cctccgcctg cagggggatg ccttgtctgt
     1141 gggtggctat gaggccaacc ccatcttttg ggatgaggtg tcagacaaat ttgcctttgg
     1201 cctctttgac ctggactggg atgtgttcac tcagcacatt gaaggtgcca ttaaccgtgt
     1261 ccccgtgttg gagaaaacgg ggatcaagtc cactgtctgt ggccctgaat ccttcacacc
     1321 cgaccataag cccctgatgg gggaggctcc tgagctccga ggcttcttcc ttggctgtgg
     1381 cttcaacagt gcaggcatga tgttgggtgg tggctgtgga caggagctgg cccattggat
     1441 tgtgcatggg cgcccagaga aggacatgta cagctatgac atcaggcgtt tccaccactc
     1501 gctcacggac cacccacgct ggatccgaga gcgcagccac gagtcctatg ccaagaacta
     1561 ctcggttgtc tttcctcacg atgagcccct ggcgggccgc aacatgagga gggaccctct
     1621 gcacgaggag ctgcttggac aaggctgtgt gtttcaagaa cgacagggct gggaacggcc
     1681 aggatggttc aacccccaag aaacagctca ggtcctagac tacgactact atggggccta
     1741 cggacaccag gcacacaagg actacgccta cagcaggctg ctgggcgatg aatatacctt
     1801 cgacttccca ccccaccact gcgtgatcca gaaggaatgt ctggcctgca gaacggctgc
     1861 cgccgtgttc aacatgtctt acttcgggaa gttctacctt ctgggggcag acgccaggaa
     1921 ggctgcagac tggctcttct cagcagatgt caaccgaccc ccaggctcca cggtgtacac
     1981 atgcatgctg aaccaacggg gaggcaccga gagcgacctg actgttagct gcctggcccc
     2041 tggtgcccag gccagtcccc tggcccctgc ctttgaaggg gatggctact acctagccgt
     2101 aggtggggct gtggcccaac ataactggtc ccacataaac acggtgctgc aggatcagga
     2161 gttccggtgc cagcttatgg attgttctga agatctgggc atgctcagta tccagggccc
     2221 agccagccgt gacattctcc aggatgtgct tgatgctgac ctgagcaatg aagccttccc
     2281 cttctccacc caccagctgg tgagagctgc tggacacctg gtccgagcca tccggctatc
     2341 ctttgtcggg gagctgggat gggagctgca tgtgccccaa gcgtcctgct tgcctgtgta
     2401 ccgggctgtg atggctgcag gggcgaagca cggcctagtc aatgcaggct accgtgccat
     2461 cgactccctg agcattgaga aaggctatcg gcactggcat gcagacctga ggtccgatga
     2521 cagccccctg gaggcagggt tggccttcac ctgcaagctc aagacctcag tgcccttcct
     2581 aggccgagag gccctggaga agcagcgtgc cacaggcctc cgacgacgcc tggtgtgcct
     2641 cactgtggaa gaggaggttc ctatgttcgg cctagaggcc atctggagaa atggccaagt
     2701 ggtgggccat gtccggagag ctgactttgg attcaccgtg aacaagacca tcgcctatgg
     2761 ctacatccga gaccccagtg gagggccagt ctctctggac tttgtgaaga atggggacta
     2821 tgccttggag agaatggggg tcacctatgc tgcccaggtt cacctgaagt ctccctttga
     2881 tcctgacaac aagcgggtga agggaatcta ttgatgggct gcagggtgga ggctacagct
     2941 gctcaggccc ctggaaactg ccacacttcc catacggcct gtggactcct atactgtaca
     3001 aacagccctg tgtcctgaga cccaagataa gggcaaaaca cagacttccc accctgagcc
     3061 tccatctggt cctgctaact gccacagctc ctaaccagta ccacatggac cactatgttc
     3121 ctcctgctca cagaccacac agtggtctcc aatccactct agccctccca aaatgcaccc
     3181 tgcagatgtc tgggctcaag gtccctgtgt atggttaacc caagatagaa gccataaagc
     3241 aagcaggcat ccagtctgtc cctcacttgg ctgactgcag tgggtagctg gagtgtctga
     3301 agggtagtgg attgggagag tgagcaggga ttgatgagta atgtctgcca tgggtatagg
     3361 atggaggaca cagagacagg tgctggactg gtacagtcct tcttcggaat ggttgccttt
     3421 tagaccagag agaagaagga taagcaggct cttgccccta gccttccagc tctgcaggag
     3481 agaaagcctt ctgagagtca ccaaccagtg acacagaagg catgtggcat gggatttgga
     3541 tcaggaacct cacttacaaa gaagtgtcat actctgcctc agtttcccct caagccattg
     3601 ctcatgggtc tggagacacc aagctttcac tcgtgcataa cccagctgca gtgtatgttt
     3661 ccaaggactt tttatttctg tcacagatgc atggcttcct gatcaagctc tagtgagggg
     3721 ctgctccagt tctgctttgt gagatagagt ggcctcttct cccaccctgt gtaaccatcc
     3781 acatatgtcc tcatatcagg ggcaccctgc ctctccttcc tggggtgaac agccatcact
     3841 tttctgtaga cccaaccttc ttcctctgtc tcacgccctg actgagaaat cgggctgctg
     3901 tagctcccca aacaaagatc accgtgtagc cttatgtgcc ttgtagtcta ggagagaagg
     3961 aggccattgc agtatggagt tgggtgtctt aaacccaaag aagtcagcag aagggagatg
     4021 tgggcacaat tgtcctgggt gggctctgaa tcttcataga ttcacacacc acacactgtg
     4081 ccggaaaaag gtcaagttaa taaaatttta cgaaaccgtt
//
LOCUS       NM_022266               2349 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus cellular communication network factor 2 (Ccn2),
            mRNA.
ACCESSION   NM_022266
VERSION     NM_022266.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Yang,Y., Long,J., Yang,J., Zheng,H., Lai,Y., Chen,C., Tang,F.,
            Gao,Y., Chen,L. and He,Z.
  TITLE     METTL3-dependent m6A modification mediates bladder remodeling after
            partial bladder outlet obstruction through CCN2 activation
  JOURNAL   Neurourol Urodyn 42 (7), 1506-1521 (2023)
   PUBMED   37455557
  REMARK    GeneRIF: METTL3-dependent m6A modification mediates bladder
            remodeling after partial bladder outlet obstruction through CCN2
            activation.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Song,X., Cui,Y. and Zhu,T.
  TITLE     MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting
            connective tissue growth factor
  JOURNAL   Am J Med Sci 365 (4), 375-385 (2023)
   PUBMED   36539014
  REMARK    GeneRIF: MicroRNA-19 upregulation attenuates cardiac fibrosis via
            targeting connective tissue growth factor.
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Pi,L., Sun,C., Jn-Simon,N., Basha,S., Thomas,H., Figueroa,V.,
            Zarrinpar,A., Cao,Q. and Petersen,B.
  TITLE     CCN2/CTGF promotes liver fibrosis through crosstalk with the
            Slit2/Robo signaling
  JOURNAL   J Cell Commun Signal 17 (1), 137-150 (2023)
   PUBMED   36469291
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Yanagihara,T., Tsubouchi,K., Gholiof,M., Chong,S.G., Lipson,K.E.,
            Zhou,Q., Scallan,C., Upagupta,C., Tikkanen,J., Keshavjee,S., Ask,K.
            and Kolb,M.R.J.
  TITLE     Connective-Tissue Growth Factor Contributes to TGF-beta1-induced
            Lung Fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 66 (3), 260-270 (2022)
   PUBMED   34797990
  REMARK    GeneRIF: Connective-Tissue Growth Factor Contributes to
            TGF-beta1-induced Lung Fibrosis.
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Zhang,S., Wang,N., Ma,Q., Fan,F. and Ma,X.
  TITLE     LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF
            expression by sponging miR-133b in myocardial fibrosis after
            myocardial infarction
  JOURNAL   Cell Biol Int 45 (12), 2534-2543 (2021)
   PUBMED   34553456
  REMARK    GeneRIF: LncRNA TUG1 acts as a competing endogenous RNA to mediate
            CTGF expression by sponging miR-133b in myocardial fibrosis after
            myocardial infarction.
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Babic,A.M., Chen,C.C. and Lau,L.F.
  TITLE     Fisp12/mouse connective tissue growth factor mediates endothelial
            cell adhesion and migration through integrin alphavbeta3, promotes
            endothelial cell survival, and induces angiogenesis in vivo
  JOURNAL   Mol Cell Biol 19 (4), 2958-2966 (1999)
   PUBMED   10082563
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Murphy,M., Godson,C., Cannon,S., Kato,S., Mackenzie,H.S., Martin,F.
            and Brady,H.R.
  TITLE     Suppression subtractive hybridization identifies high glucose
            levels as a stimulus for expression of connective tissue growth
            factor and other genes in human mesangial cells
  JOURNAL   J Biol Chem 274 (9), 5830-5834 (1999)
   PUBMED   10026205
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Perbal,B., Martinerie,C., Sainson,R., Werner,M., He,B. and
            Roizman,B.
  TITLE     The C-terminal domain of the regulatory protein NOVH is sufficient
            to promote interaction with fibulin 1C: a clue for a role of NOVH
            in cell-adhesion signaling
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 869-874 (1999)
   PUBMED   9927660
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Kireeva,M.L., Latinkic,B.V., Kolesnikova,T.V., Chen,C.C.,
            Yang,G.P., Abler,A.S. and Lau,L.F.
  TITLE     Cyr61 and Fisp12 are both ECM-associated signaling molecules:
            activities, metabolism, and localization during development
  JOURNAL   Exp Cell Res 233 (1), 63-77 (1997)
   PUBMED   9184077
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Ryseck,R.P., Macdonald-Bravo,H., Mattei,M.G. and Bravo,R.
  TITLE     Structure, mapping, and expression of fisp-12, a growth
            factor-inducible gene encoding a secreted cysteine-rich protein
  JOURNAL   Cell Growth Differ 2 (5), 225-233 (1991)
   PUBMED   1888698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF120275.1 and AB023068.1.
            
            On Oct 28, 2005 this sequence version replaced NM_022266.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF120275.1, AB023068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2327              AF120275.1         1-2327
            2328-2349           AB023068.1         2317-2338
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2349
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="cellular communication network factor 2"
                     /db_xref="GeneID:64032"
                     /db_xref="RGD:621392"
     exon            1..284
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1268
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="connective tissue growth-related protein; CCN
                     family member 2; connective tissue growth factor"
                     /codon_start=1
                     /product="CCN family member 2 precursor"
                     /protein_id="NP_071602.1"
                     /db_xref="GeneID:64032"
                     /db_xref="RGD:621392"
                     /translation="MLASVAGPVSLALVLLLCTRPATGQDCSAQCQCAAEAAPRCPAG
                     VSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCV
                     FGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCE
                     EWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTR
                     VTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKT
                     YRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIF
                     ESLYYRKMYGDMA"
     sig_peptide     225..296
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     297..1265
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /product="CCN family member 2. /id=PRO_0000014405"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E9.1)"
     misc_feature    <339..464
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="Insulin-like growth factor binding protein; Region:
                     IGFBP; pfam00219"
                     /db_xref="CDD:459717"
     misc_feature    <339..464
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="Insulin-like growth factor binding protein; Region:
                     IGFBP; pfam00219"
                     /db_xref="CDD:459717"
     misc_feature    525..704
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="von Willebrand factor (vWF) type C domain; Region:
                     VWC; smart00214"
                     /db_xref="CDD:214564"
     misc_feature    525..704
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="von Willebrand factor (vWF) type C domain; Region:
                     VWC; smart00214"
                     /db_xref="CDD:214564"
     misc_feature    813..944
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="CCN3 Nov like TSP1 domain; Region: TSP1_CCN;
                     pfam19035"
                     /db_xref="CDD:465952"
     misc_feature    813..944
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="CCN3 Nov like TSP1 domain; Region: TSP1_CCN;
                     pfam19035"
                     /db_xref="CDD:465952"
     misc_feature    957..1265
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E9.1);
                     Region: Heparin-binding.
                     /evidence=ECO:0000250|UniProtKB:P29279"
     misc_feature    975..1253
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl21545"
                     /db_xref="CDD:473907"
     misc_feature    975..1253
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl21545"
                     /db_xref="CDD:473907"
     exon            285..507
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            508..759
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..971
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2336
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagctctt ctctccaaga agactcagcc agacccactc cagctccgac cctaggagac
       61 cgacctcctc cagacggcag cagccccagc ccagtggaca accccaggag ccaccacctg
      121 gagcgtccgg acaccaacct ccgccccgag accgagtcca ggctccggcc gcgcccctcg
      181 tcgcctctgc accccgctgt gcgtcctcct gccgcgcccc gaccatgctc gcctccgtcg
      241 cgggtcccgt tagcctcgcc ttggtgctcc tcctctgcac ccggcctgcc accggccagg
      301 actgcagcgc gcagtgtcag tgcgcagctg aagcggcgcc gcgctgcccc gccggcgtga
      361 gcctggtgct ggacggctgc ggctgctgcc gcgtctgcgc caagcagctg ggagaactgt
      421 gcacggagcg tgatccctgc gacccacaca agggtctctt ctgcgacttc ggctcccccg
      481 ccaaccgcaa gattggcgtg tgcactgcca aagatggtgc accctgtgtc ttcggtgggt
      541 ccgtgtaccg cagcggcgag tccttccaaa gcagttgcaa ataccagtgc acttgcctgg
      601 atggggccgt gggctgtgtg cccctgtgca gcatggacgt gcgcctgccc agccctgact
      661 gccccttccc gagaagggtc aagctgcccg ggaaatgctg tgaggagtgg gtgtgtgatg
      721 agcccaagga ccgcacagtg gttggccctg ccctagctgc ctaccgactg gaagacacat
      781 ttggccctga cccaactatg atgcgagcca actgcctggt ccagaccaca gagtggagcg
      841 cctgttctaa gacctgtggg atgggcatct ccacccgggt taccaatgac aataccttct
      901 gcaggctgga gaagcagagt cgtctctgca tggtcaggcc ctgtgaagct gacctagagg
      961 aaaacattaa gaagggcaaa aagtgcatcc ggacgcctaa aattgccaag cctgtcaagt
     1021 ttgagctttc tggctgcacc agtgtgaaga cctaccgggc taagttctgt ggggtgtgca
     1081 cggacggccg ctgctgcaca ccgcacagaa ccaccacact gccggtggag ttcaagtgcc
     1141 ccgatggcga gatcatgaaa aagaacatga tgttcatcaa gacctgtgcc tgccattaca
     1201 actgtcccgg ggacaatgac atctttgagt ccttgtacta caggaagatg tatggagaca
     1261 tggcgtaaag ccagggagta agggacacga actcatttag actataactt gaactgagtt
     1321 acatctcatt ttcttctgta aaaaaacaaa aaggattaca gtagcacatt aatttaaatc
     1381 tgggttccta actgctgtgg gagaaaacac cccaccgaag tgagaaccgt gtgtcattgt
     1441 catgcaaata gcctgtcaat ctcagacact ggtttcgaga cagtttagac ttgacagttg
     1501 ttcactagcg cacagtgaca gaacgcacac taaggtgagc ctcctggaag agtggagatg
     1561 ccaggagaaa gacaggtact agctgaggtc attttaaaag cagcgatatg cctacttttt
     1621 ggagtgtgac aggggaggga cattatagct tgcttgcaga cagacctgct ctagcaagag
     1681 ctgggtgtgt gtcctccact cggtgaggct gaagccagct attctttcag taagaacagc
     1741 agtttcagcg ctgacattct gattccagtg acactggtcg ggagtcagaa ccttgtctat
     1801 tagactggac agcttgtggc aagtgaattt gccggtaaca agccagattt ttatggatct
     1861 tgtaaatatt gtggataaat atatatattt gtacagttat ctaagttaat ttaaagacgt
     1921 ttgtgcctat tgttcttgtt ttaagtgctt ttggaatttt taaactgata gcctcaaact
     1981 ccaaacacca tcgataggac ataaagcttg tctgtgattc aaaacaaagg agatactgca
     2041 gtggaaactg taacctgagt gactgtctgt cagaacatat ggtacgtaga cggtaaagca
     2101 atggatcaga agtcagattt ctagtaggaa atgtaaaatc actgttggcg aacaaatggc
     2161 ctttattaag aaatggcttg ctcagggtaa ctggtcagat ttccacgagg aagtgtttgc
     2221 tgcttctttg actatgactg gtttgggagg cagtttattt gttgagagtg tgaccaaaag
     2281 ttacatgttt gcacctttct agttgaaaat aaagtatata tattttttat atgaaaaaaa
     2341 aaaaaaaaa
//
LOCUS       NM_001130490           14714 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus LDL receptor related protein 1 (Lrp1), mRNA.
ACCESSION   NM_001130490
VERSION     NM_001130490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 14714)
  AUTHORS   Wang,H., Liang,L., Yang,C., Xiao,L., Wang,H., Wang,G. and Zhu,Z.
  TITLE     The protective role of hippocampal LRP1 knockdown involves synaptic
            plasticity through the promoting microtubule dynamics and
            activation of Akt/GSK-3beta pathway in depressive rats
  JOURNAL   J Affect Disord 322, 63-75 (2023)
   PUBMED   36372121
  REMARK    GeneRIF: The protective role of hippocampal LRP1 knockdown involves
            synaptic plasticity through the promoting microtubule dynamics and
            activation of Akt/GSK-3beta pathway in depressive rats.
REFERENCE   2  (bases 1 to 14714)
  AUTHORS   Haghjoo,S., Hedayati Ch,M., Rostampour,M. and Khakpour-Taleghani,B.
  TITLE     Red-light radiation: does it enhance memory by increasing
            hippocampal LRP-1 and TRPA-1 genes expression?
  JOURNAL   Int J Radiat Biol 99 (2), 329-339 (2023)
   PUBMED   35446172
  REMARK    GeneRIF: Red-light radiation: does it enhance memory by increasing
            hippocampal LRP-1 and TRPA-1 genes expression?
REFERENCE   3  (bases 1 to 14714)
  AUTHORS   Taghadosi,Z., Zarifkar,A., Razban,V. and Aligholi,H.
  TITLE     The effect of chronic stress and its preconditioning on spatial
            memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease
  JOURNAL   Metab Brain Dis 37 (8), 2699-2710 (2022)
   PUBMED   35930096
  REMARK    GeneRIF: The effect of chronic stress and its preconditioning on
            spatial memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease.
REFERENCE   4  (bases 1 to 14714)
  AUTHORS   Garcia,J., Chang,R., Steinberg,R.A., Arce,A., Yang,J., Van Der
            Eb,P., Abdullah,T., Chandrashekar,D.V., Eck,S.M., Meza,P.,
            Liu,Z.X., Cadenas,E., Cribbs,D.H., Kaplowitz,N., Sumbria,R.K. and
            Han,D.
  TITLE     Modulation of hepatic amyloid precursor protein and lipoprotein
            receptor-related protein 1 by chronic alcohol intake: Potential
            link between liver steatosis and amyloid-beta
  JOURNAL   Front Physiol 13, 930402 (2022)
   PUBMED   36187787
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14714)
  AUTHORS   Mantuano,E., Azmoon,P., Banki,M.A., Lam,M.S., Sigurdson,C.J. and
            Gonias,S.L.
  TITLE     A soluble derivative of PrPC activates cell-signaling and regulates
            cell physiology through LRP1 and the NMDA receptor
  JOURNAL   J Biol Chem 295 (41), 14178-14188 (2020)
   PUBMED   32788217
  REMARK    GeneRIF: A soluble derivative of PrP(C) activates cell-signaling
            and regulates cell physiology through LRP1 and the NMDA receptor.
REFERENCE   6  (bases 1 to 14714)
  AUTHORS   Brown,M.D., Banker,G.A., Hussaini,I.M., Gonias,S.L. and
            VandenBerg,S.R.
  TITLE     Low density lipoprotein receptor-related protein is expressed early
            and becomes restricted to a somatodendritic domain during neuronal
            differentiation in culture
  JOURNAL   Brain Res 747 (2), 313-317 (1997)
   PUBMED   9046007
REFERENCE   7  (bases 1 to 14714)
  AUTHORS   Ishii,M., Osada,T., Gliemann,J. and Ikai,A.
  TITLE     Neurite-promoting effect of alpha 2-macroglobulin in rat cerebral
            cortex is mainly associated with alpha 2-macroglobulin receptor
  JOURNAL   Brain Res 737 (1-2), 269-274 (1996)
   PUBMED   8930375
REFERENCE   8  (bases 1 to 14714)
  AUTHORS   Stefansson,S., Lawrence,D.A. and Argraves,W.S.
  TITLE     Plasminogen activator inhibitor-1 and vitronectin promote the
            cellular clearance of thrombin by low density lipoprotein
            receptor-related proteins 1 and 2
  JOURNAL   J Biol Chem 271 (14), 8215-8220 (1996)
   PUBMED   8626514
REFERENCE   9  (bases 1 to 14714)
  AUTHORS   Beisiegel,U., Weber,W., Ihrke,G., Herz,J. and Stanley,K.K.
  TITLE     The LDL-receptor-related protein, LRP, is an apolipoprotein
            E-binding protein
  JOURNAL   Nature 341 (6238), 162-164 (1989)
   PUBMED   2779654
REFERENCE   10 (bases 1 to 14714)
  AUTHORS   Herz,J., Hamann,U., Rogne,S., Myklebost,O., Gausepohl,H. and
            Stanley,K.K.
  TITLE     Surface location and high affinity for calcium of a 500-kd liver
            membrane protein closely related to the LDL-receptor suggest a
            physiological role as lipoprotein receptor
  JOURNAL   EMBO J 7 (13), 4119-4127 (1988)
   PUBMED   3266596
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..14714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..14714
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="LDL receptor related protein 1"
                     /db_xref="GeneID:299858"
                     /db_xref="RGD:1307535"
     exon            1..415
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    259..261
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="upstream in-frame stop codon"
     CDS             346..13983
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="prolow-density lipoprotein receptor-related protein
                     1; low density lipoprotein-related protein 1
                     (alpha-2-macroglobulin receptor); low density lipoprotein
                     receptor-related protein 1"
                     /codon_start=1
                     /product="prolow-density lipoprotein receptor-related
                     protein 1 precursor"
                     /protein_id="NP_001123962.1"
                     /db_xref="GeneID:299858"
                     /db_xref="RGD:1307535"
                     /translation="MLTPPLLLLLPLLSALVAGATMDAPKTCSPKQFACRDQITCISK
                     GWRCDGERDCPDGSDEAPEICPQSKAQRCPPNEHSCLGTELCVPMSRLCNGIQDCMDG
                     SDEGAHCRELRVNCSRMGCQHHCVPTPSGPTCYCNNSFQLQADGKTCKDFDECSVYGT
                     CSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA
                     QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPSLKGFVDEHTINI
                     SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA
                     MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYI
                     EVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANTQQKTSVIRVNRFNSTE
                     YQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCR
                     SGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALD
                     FHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP
                     KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLER
                     AWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEG
                     PELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVAGAQPTVTLLRSERPPIFEIRMYDA
                     QQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQ
                     PGEFACANNRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWL
                     CDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASC
                     AYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIP
                     EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTD
                     CMDSSDEKGCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALAC
                     RPPSHPCANNTSVCLSPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEG
                     IVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESC
                     RSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVED
                     KIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTL
                     RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTIHRETGSGGW
                     PNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYW
                     TDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGRGPCSH
                     LCLINYNRTVSCACPHLMKLHNDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISF
                     TVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDW
                     VSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNIS
                     MVNMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMR
                     SQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQ
                     LEHEGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHE
                     GIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRE
                     DVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITV
                     HPEKGYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARM
                     DKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDS
                     VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGGGQRACACAHGMLAE
                     DGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGT
                     SPGTPNRIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTS
                     TITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNELHPSIMRAAL
                     SGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVH
                     PFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCEL
                     SPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRAMNSSCRAQDEFECANGEC
                     ISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGS
                     DEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVK
                     GVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPM
                     SWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC
                     EGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESISAGCLYNSTCDDREFMCQN
                     RLCIPKHFVCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCH
                     DHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNE
                     CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQLCINTHG
                     SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNA
                     VALDFDYRGQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLY
                     WCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGM
                     DGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPH
                     IFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLHRPMDLHVFHALRQPDVPN
                     HPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTCVSNCTASQFVCKNDKCIPF
                     WWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEAN
                     CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKR
                     CIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDG
                     SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFS
                     CANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCM
                     DGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECTRFQCPP
                     NRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAQNPHCKDKKEFLCRNQRCL
                     SSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASMCGDEARCVRTEKAAYCACRPGF
                     HTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLY
                     IADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSL
                     PPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQM
                     KGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQ
                     WPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAVDSKRGLSHPFSIDVFEDYIY
                     GVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCL
                     LSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFLNARRQPK
                     CRCQPRYTGDKCELDQCWEYCHNGGTCAASPSGMPTCRCPTGFTGPRCTQQVCAGYCA
                     NNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFE
                     GTRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTMNSKM
                     MPECQCPPHMTGPRCEEQVVSQQQPGHMTSILIPLLLLLLLLLVAGVVFWYKRRVRGA
                     KGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYAT
                     LYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA"
     sig_peptide     346..402
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     403..13980
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /product="Prolow-density lipoprotein receptor-related
                     protein 1. /evidence=ECO:0000255. /id=PRO_5015091774"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1)"
     misc_feature    424..525
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    424..525
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(442..444,469..471,502..507)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(442..444,469..471,502..507)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(481..483,490..492,502..504,520..525)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(481..483,490..492,502..504,520..525)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    511..525
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    511..525
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    559..660
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    559..660
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(577..579,604..606,637..642)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(577..579,604..606,637..642)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(616..618,625..627,637..639,655..660)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(616..618,625..627,637..639,655..660)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    646..660
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    646..660
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    688..690
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    703..792
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    703..792
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    754..756
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    820..912
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    820..912
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    901..903
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    1063..1065
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    1168..1170
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    1171..1290
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1171..1290
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1222..1350
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    1294..1422
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1294..1422
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1351..1482
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    1417..1419
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    1429..1551
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1429..1551
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1483..1614
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    1684..1686
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    1804..1905
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1804..1905
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1999..2127
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1999..2127
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2059..2187
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    2128..2247
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2128..2247
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2188..2325
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    2260..2358
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 1. /evidence=ECO:0000255"
     misc_feature    2266..2415
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2266..2415
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2326..2478
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    <2446..2547
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    <2446..2547
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2479..2610
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    2533..2535
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    2767..2874
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    2767..2874
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    2905..3003
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    2905..3003
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(2923..2925,2947..2949,2980..2985)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(2923..2925,2947..2949,2980..2985)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(2959..2961,2968..2970,2980..2982,2998..3003)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(2959..2961,2968..2970,2980..2982,2998..3003)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    2989..3003
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    2989..3003
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3031..3132
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3031..3132
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3046..3048,3070..3072,3103..3108)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3046..3048,3070..3072,3103..3108)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3082..3084,3091..3093,3103..3105,3121..3126)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3082..3084,3091..3093,3103..3105,3121..3126)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3112..3126
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3112..3126
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3130..3132
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    3151..3249
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    3151..3249
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(3169..3171,3193..3195,3226..3231)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3169..3171,3193..3195,3226..3231)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3205..3207,3214..3216,3226..3228,3244..3249)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3205..3207,3214..3216,3226..3228,3244..3249)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3235..3249
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3235..3249
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3280..3381
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3280..3381
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3292..3294,3316..3318,3349..3354)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3292..3294,3316..3318,3349..3354)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3328..3330,3337..3339,3349..3351,3367..3372)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3328..3330,3337..3339,3349..3351,3367..3372)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3358..3372
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3358..3372
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3391..3492
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3391..3492
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3406..3408,3430..3432,3463..3468)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3406..3408,3430..3432,3463..3468)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3442..3444,3451..3453,3463..3465,3481..3486)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3442..3444,3451..3453,3463..3465,3481..3486)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3472..3486
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3472..3486
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3496..3498
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    3532..3639
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3532..3639
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3547..3549,3574..3576,3607..3612)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3547..3549,3574..3576,3607..3612)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3586..3588,3595..3597,3607..3609,3625..3630)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3586..3588,3595..3597,3607..3609,3625..3630)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3616..3630
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3616..3630
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3658..3768
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3658..3768
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3676..3678,3703..3705,3736..3741)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3676..3678,3703..3705,3736..3741)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3715..3717,3724..3726,3736..3738,3754..3759)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3715..3717,3724..3726,3736..3738,3754..3759)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3745..3759
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3745..3759
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3781..3882
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3781..3882
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3796..3798,3826..3828,3859..3864)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3796..3798,3826..3828,3859..3864)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    3811..3813
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    order(3838..3840,3847..3849,3859..3861,3877..3882)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3838..3840,3847..3849,3859..3861,3877..3882)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3868..3882
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3868..3882
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3901..4011
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3901..4011
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3931..3933
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    4000..4002
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    4273..4413
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 8.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    4276..>4857
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Streptogramin lyase [Defense mechanisms]; Region:
                     Vgb; COG4257"
                     /db_xref="CDD:443399"
     misc_feature    4276..>4857
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Streptogramin lyase [Defense mechanisms]; Region:
                     Vgb; COG4257"
                     /db_xref="CDD:443399"
     misc_feature    4354..4476
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    4354..4476
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    4414..4542
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 9.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    4483..4584
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 2. /evidence=ECO:0000255"
     misc_feature    4486..4617
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    4486..4617
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    4543..4683
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 10.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    4684..4818
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 11.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    4753..4854
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 3. /evidence=ECO:0000255"
     misc_feature    4819..4941
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 12.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    4879..4881
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5020..5022
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5071..5073
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5185..5295
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5185..5295
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5194..5196
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5227..5355
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 13.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    5281..5283
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5296..5427
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5296..5427
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5302..5397
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 4. /evidence=ECO:0000255"
     misc_feature    5356..5487
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 14.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    5437..5550
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5437..5550
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5488..5607
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 15.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    5515..5517
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5545..5547
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5548..5673
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5548..5673
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    5608..5742
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 16.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    5635..5637
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5821..5823
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    5896..6006
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    5896..6006
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    6094..6216
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6094..6216
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6145..6147
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    6148..6276
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 17.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    6223..6345
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6223..6345
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6277..6405
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 18.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    6331..6333
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    6346..6477
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6346..6477
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6373..6375
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); acetylation site"
     misc_feature    6406..6537
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 19.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    6481..6609
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6481..6609
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    6490..6492
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    6538..6669
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 20.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    6697..6699
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    6727..6729
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    6823..6930
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    6823..6930
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    7105..7230
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 21.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    7171..7293
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    7171..7293
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    7174..7272
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 5. /evidence=ECO:0000255"
     misc_feature    7231..7377
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 22.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    7318..7419
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 6. /evidence=ECO:0000255"
     misc_feature    7378..7512
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 23.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    7378..7506
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    7378..7506
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    7456..7581
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    7456..7581
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    7513..7641
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 24.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    7576..7677
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 7. /evidence=ECO:0000255"
     misc_feature    7642..7767
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 25.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    7762..7764
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    7792..7890
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    7792..7890
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    7852..7854
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    7909..7911
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    7927..8019
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    7927..8019
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(7936..7938,7960..7962,7993..7998)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(7936..7938,7960..7962,7993..7998)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(7972..7974,7981..7983,7993..7995,8011..8016)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(7972..7974,7981..7983,7993..7995,8011..8016)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8002..8016
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8002..8016
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8044..8148
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    8044..8148
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(8059..8061,8083..8085,8116..8121)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8059..8061,8083..8085,8116..8121)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8095..8097,8104..8106,8116..8118,8134..8139)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8095..8097,8104..8106,8116..8118,8134..8139)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8125..8139
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8125..8139
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8149..8151
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    8161..8265
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    8161..8265
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(8176..8178,8200..8202,8233..8238)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8176..8178,8200..8202,8233..8238)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    8206..8208
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    order(8212..8214,8221..8223,8233..8235,8251..8256)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8212..8214,8221..8223,8233..8235,8251..8256)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8242..8256
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8242..8256
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8260..8262
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    <8344..8412
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    <8344..8412
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(8359..8361,8368..8370,8380..8382,8398..8403)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8359..8361,8368..8370,8380..8382,8398..8403)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8389..8403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8389..8403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8434..8538
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    8434..8538
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(8449..8451,8473..8475,8506..8511)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8449..8451,8473..8475,8506..8511)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8485..8487,8494..8496,8506..8508,8524..8529)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8485..8487,8494..8496,8506..8508,8524..8529)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8515..8529
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8515..8529
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8548..8643
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    8548..8643
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(8563..8565,8587..8589,8620..8625)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8563..8565,8587..8589,8620..8625)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8599..8601,8608..8610,8620..8622,8638..8643)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8599..8601,8608..8610,8620..8622,8638..8643)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8629..8643
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8629..8643
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8665..8766
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    8665..8766
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(8683..8685,8710..8712,8743..8748)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8683..8685,8710..8712,8743..8748)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8722..8724,8731..8733,8743..8745,8761..8766)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8722..8724,8731..8733,8743..8745,8761..8766)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8752..8766
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8752..8766
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8791..8793
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    8797..8895
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    8797..8895
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(8815..8817,8839..8841,8872..8877)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8815..8817,8839..8841,8872..8877)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8851..8853,8860..8862,8872..8874,8890..8895)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8851..8853,8860..8862,8872..8874,8890..8895)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    8881..8895
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8881..8895
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    8917..9018
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    8917..9018
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(8935..8937,8959..8961,8995..9000)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8935..8937,8959..8961,8995..9000)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(8974..8976,8983..8985,8995..8997,9013..9018)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(8974..8976,8983..8985,8995..8997,9013..9018)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    9004..9018
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    9004..9018
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    9061..9063
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    9067..9165
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    9067..9165
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(9076..9078,9100..9102,9133..9138)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(9076..9078,9100..9102,9133..9138)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(9112..9114,9121..9123,9133..9135,9151..9156)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(9112..9114,9121..9123,9133..9135,9151..9156)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    9142..9156
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    9142..9156
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    9238..9303
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Complement Clr-like EGF-like; Region: cEGF;
                     pfam12662"
                     /db_xref="CDD:463661"
     misc_feature    9238..9303
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Complement Clr-like EGF-like; Region: cEGF;
                     pfam12662"
                     /db_xref="CDD:463661"
     misc_feature    9292..>9381
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Calcium-binding EGF-like domain; Region: EGF_CA;
                     smart00179"
                     /db_xref="CDD:214542"
     misc_feature    9292..>9381
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Calcium-binding EGF-like domain; Region: EGF_CA;
                     smart00179"
                     /db_xref="CDD:214542"
     misc_feature    order(9292..9294,9301..9303,9340..9342)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(9292..9294,9301..9303,9340..9342)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    9490..9492
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    9493..9627
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9493..9627
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9553..9687
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 26.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    9613..9615
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    9628..9756
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9628..9756
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9688..9816
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 27.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    9727..9858
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 8. /evidence=ECO:0000255"
     misc_feature    9760..9888
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9760..9888
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9817..9948
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 28.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    9892..10017
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9892..10017
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    9949..10077
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 29.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    10015..10113
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 9. /evidence=ECO:0000255"
     misc_feature    10018..10140
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    10018..10140
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    10078..10200
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 30.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    10138..10140
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    10228..10338
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    10228..10338
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    10345..10347
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    10348..10443
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    10348..10443
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(10363..10365,10387..10389,10420..10425)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10363..10365,10387..10389,10420..10425)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10399..10401,10408..10410,10420..10422,10438..10443)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(10399..10401,10408..10410,10420..10422,10438..10443)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    10429..10443
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10429..10443
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10468..10572
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    10468..10572
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(10483..10485,10507..10509,10540..10545)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10483..10485,10507..10509,10540..10545)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10519..10521,10528..10530,10540..10542,10558..10563)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(10519..10521,10528..10530,10540..10542,10558..10563)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    10549..10563
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10549..10563
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10585..10692
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    10585..10692
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(10600..10602,10627..10629,10660..10665)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10600..10602,10627..10629,10660..10665)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10639..10641,10648..10650,10660..10662,10678..10683)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(10639..10641,10648..10650,10660..10662,10678..10683)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    10669..10683
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10669..10683
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10702..10803
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    10702..10803
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(10720..10722,10747..10749,10780..10785)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10720..10722,10747..10749,10780..10785)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10759..10761,10768..10770,10780..10782,10798..10803)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(10759..10761,10768..10770,10780..10782,10798..10803)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    10789..10803
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10789..10803
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10810..10812
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    10825..10926
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    10825..10926
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(10843..10845,10870..10872,10903..10908)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10843..10845,10870..10872,10903..10908)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10882..10884,10891..10893,10903..10905,10921..10926)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(10882..10884,10891..10893,10903..10905,10921..10926)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    10912..10926
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10912..10926
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    10954..11058
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    10954..11058
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(10969..10971,10993..10995,11026..11031)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(10969..10971,10993..10995,11026..11031)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11005..11007,11014..11016,11026..11028,11044..11049)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11005..11007,11014..11016,11026..11028,11044..11049)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11035..11049
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11035..11049
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11071..11175
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    11071..11175
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(11086..11088,11110..11112,11143..11148)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11086..11088,11110..11112,11143..11148)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11122..11124,11131..11133,11143..11145,11161..11166)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11122..11124,11131..11133,11143..11145,11161..11166)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11152..11166
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11152..11166
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11185..11289
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    11185..11289
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(11200..11202,11224..11226,11257..11262)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11200..11202,11224..11226,11257..11262)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11236..11238,11245..11247,11257..11259,11275..11280)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11236..11238,11245..11247,11257..11259,11275..11280)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11266..11280
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11266..11280
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11305..11403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    11305..11403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    order(11323..11325,11347..11349,11380..11385)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11323..11325,11347..11349,11380..11385)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    11332..11334
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    order(11359..11361,11368..11370,11380..11382,11398..11403)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11359..11361,11368..11370,11380..11382,11398..11403)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11389..11403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11389..11403
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11431..11541
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    11431..11541
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(11449..11451,11476..11478,11509..11514)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11449..11451,11476..11478,11509..11514)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11488..11490,11497..11499,11509..11511,11527..11532)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11488..11490,11497..11499,11509..11511,11527..11532)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11518..11532
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11518..11532
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11584..11676
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    11584..11676
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(11587..11589,11611..11613,11644..11649)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11587..11589,11611..11613,11644..11649)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(11623..11625,11632..11634,11644..11646,11662..11667)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(11623..11625,11632..11634,11644..11646,11662..11667)
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    11653..11667
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11653..11667
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    11710..11712
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    11863..11865
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    11932..12540
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    11932..12540
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    12082..12120
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 31.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    12205..12207
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    12211..12324
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    12211..12324
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    12256..12384
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 32.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    12328..12426
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: HAT 10. /evidence=ECO:0000255"
     misc_feature    12385..12516
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 33.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    12385..12510
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    12385..12510
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    12457..12582
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    12457..12582
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    12517..12651
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: LDL-receptor class B 34.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00461"
     misc_feature    12571..12573
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    12721..12723
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    12883..12885
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    13183..13185
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    13438..13440
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (G3V928.1); glycosylation site"
     misc_feature    13618..13680
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     transmembrane region"
     misc_feature    13681..13980
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (G3V928.1);
                     Region: Interaction with MAFB.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7"
     misc_feature    13726..13728
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); phosphorylation site"
     misc_feature    13867..13869
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); phosphorylation site"
     misc_feature    13897..13899
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); phosphorylation site"
     misc_feature    13906..13908
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); phosphorylation site"
     misc_feature    13915..13917
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91ZX7; propagated from
                     UniProtKB/Swiss-Prot (G3V928.1); phosphorylation site"
     exon            416..538
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..676
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..796
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..925
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1189
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1352
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1575
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1765
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1909
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2146
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2327
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2550
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2752
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2878
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3019
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3145
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3262
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3343
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3511
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3694
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3895
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4141
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4339
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4544
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4709
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4954
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5086
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..5314
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..5489
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5490..5584
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5585..5734
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5735..5875
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5876..6010
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6011..6142
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6143..6277
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6278..6407
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6408..6534
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6535..6686
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6687..6811
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6812..7189
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7190..7379
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7380..7584
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7585..7777
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7778..7903
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7904..8032
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8033..8152
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8153..8266
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8267..8416
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8417..8539
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8540..8656
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8657..8785
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8786..8908
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            8909..9049
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9050..9240
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9241..9424
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9425..9510
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9511..9630
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9631..9818
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            9819..10024
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10025..10213
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10214..10362
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10363..10456
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10457..10573
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10574..10693
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10694..10816
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10817..10942
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            10943..11059
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11060..11166
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11167..11299
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11300..11419
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11420..11542
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11543..11683
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11684..11818
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11819..11938
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            11939..12207
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12208..12386
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12387..12493
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12494..12610
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12611..12787
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12788..12928
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            12929..13102
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13103..13264
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13265..13439
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13440..13541
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13542..13606
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13607..13697
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13698..13842
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            13843..14714
                     /gene="Lrp1"
                     /gene_synonym="LRP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccccccac cccgcctcct cccaattgtg catttttgca gccggaggcg gctccgagat
       61 ggggctgtga gcttcgccct gggaggggga gaggagcgag gagtaaagca ggggtgaagg
      121 gttcgaattt gggggcaggg ggcgcacccg cgtcagcagg cccttcccag ggggctcgga
      181 actgtatcat ttcacctatg cccctgattc gctttgctta aggaaaggat aagaatagaa
      241 gagtcaggga gaggaagata aagggggacc ccccaattgg ggggggcgag gacaagaagt
      301 aacaggacca gagggtgggg gctgctgttt ccatcggccc acaccatgct gaccccgccg
      361 ttgctgctgc tgctgcccct gctttcagct ctggtcgccg gggccactat ggatgcccct
      421 aaaacttgca gccctaagca gtttgcctgc agagaccaaa tcacctgtat ctcgaagggc
      481 tggcggtgtg acggggaaag agattgtccg gacggctctg atgaagcccc cgagatctgt
      541 ccacagagta aagcccagag atgcccacca aatgagcaca gttgcctggg gaccgagctg
      601 tgtgtcccca tgtctcgtct ctgcaacggg atccaggatt gcatggatgg ctcagatgag
      661 ggtgctcact gccgagagct ccgtgtcaac tgttctcgaa tgggctgtca gcaccattgc
      721 gtccctacgc ccagtgggcc cacatgctac tgtaataaca gcttccagct tcaggcagac
      781 ggcaagacat gcaaagattt tgacgaatgc tctgtgtatg gcacttgcag ccagctttgc
      841 accaacacag atggctcctt cacatgtggc tgtgttgaag gttacctgct gcaaccggac
      901 aaccgctcat gcaaggccaa gaatgagcca gtagatcggc ccccggtgct actgattgcc
      961 aactcccaga acatcctagc tacgtacctg agcggagccc aggtgtctac catcacaccc
     1021 accagcaccc gacagaccac agccatggac ttcagttatg ccaacgagac tgtatgctgg
     1081 gtacatgttg gggacagtgc tgcccagacg cagctcaagt gtgcccggat gcctagcctg
     1141 aagggcttcg tggatgagca taccatcaac atctccctga gtctgcacca cgttgagcag
     1201 atggctatcg actggctgac tgggaacttc tactttgtgg atgacatcga tgacaggatc
     1261 tttgtctgta accgaaatgg ggacacctgt gtcactttgc tggacctgga gctctacaat
     1321 cccaaaggca tcgccctgga ccctgccatg gggaaggtgt tcttcactga ctacgggcag
     1381 atcccaaagg tggaacgctg tgacatggac ggacagaacc gcaccaagct ggtcgatagc
     1441 aagattgtat ttccacatgg catcaccctg gacctggtca gccgcctcgt gtactgggcg
     1501 gacgcctacc ttgactatat cgaggtggta gactatgaag gaaagggccg gcagaccatc
     1561 atccaaggca tcctgattga gcacctctat ggcctgactg tgtttgagaa ctacctctac
     1621 gccaccaact cagacaacgc caacacccag cagaagacga gcgtgatccg agtgaaccgg
     1681 ttcaacagta ccgagtacca ggtggtcacc cgtgtggaca agggcggtgc cctgcatatc
     1741 tatcaccagc gacgccagcc ccgagtgcgg agtcatgcct gtgagaatga ccagtatggg
     1801 aagccaggag gctgctctga catctgcctg ctggccaaca gccacaaggc aaggacctgc
     1861 aggtgccggt ctggcttcag tctgggaagt gacgggaaat cctgcaagaa acctgaacat
     1921 gagctgttcc tcgtgtatgg caagggccgg ccaggcatca tccgaggcat ggacatggga
     1981 gccaaggtcc cagatgagca catgatcccc atcgagaacc ttatgaatcc acgggctctg
     2041 gacttccacg ctgagactgg cttcatctac tttgctgaca ccaccagcta cctcattggc
     2101 cgccagaaaa ttgatggcac ggagagagag accatcctga aggacggcat ccacaacgtg
     2161 gagggcgtag ctgtagactg gatgggggac aacctttact ggactgatga cggccccaag
     2221 aagaccatta gtgtggccag gctggagaaa gctgcccaga cacgaaagac tctaatcgag
     2281 ggcaagatga cacaccccag ggccattgta gtggatccac tcaatgggtg gatgtactgg
     2341 acagactggg aggaagaccc caaggatagc cggcgagggc ggcttgagag ggcttggatg
     2401 gacggctcac accgagatat ctttgtcacc tccaagacag tgctttggcc caatgggcta
     2461 agcctggata tcccagctgg gcgcctctac tgggtggatg ccttctatga ccgaattgag
     2521 accatactgc tcaatggcac agaccggaag attgtatacg agggtcctga actgaatcac
     2581 gccttcggcc tgtgtcacca cggcaactac ctcttttgga ctgagtatcg gagcggcagt
     2641 gtctaccgct tggagcgggg tgtggcaggc gcacagccca ctgtgaccct tctgcgcagc
     2701 gagcgacctc ctatctttga gatccgaatg tacgacgcgc agcagcagca agtgggtacc
     2761 aacaaatgcc gggtaaataa cggaggctgc agcagtctgt gcctagccac cccggggagt
     2821 cgccagtgcg cctgcgctga ggaccaggtg ttggatgcgg atggcgtcac ctgcctggcg
     2881 aacccatcct acgtgccccc accccagtgc cagccgggcg agtttgcctg tgccaacaac
     2941 cgctgcatcc aggagcgctg gaagtgtgat ggagataacg actgtctgga caacagtgat
     3001 gaggccccgg cactgtgcca tcaacacacc tgtccctcgg accgattcaa atgtgagaac
     3061 aaccgatgta tccccaaccg ctggctctgt gatggggata acgactgtgg caacagcgag
     3121 gacgagtcca atgccacgtg ctcagcgcgc acctgcccac ccaaccagtt ctcctgtgcc
     3181 agtggccgat gcatccctat ctcttggacc tgtgatcttg atgatgactg tggggaccgc
     3241 tccgatgagt cagcctcatg cgcctacccc acctgtttcc ccctgactca gtttacctgc
     3301 aacaatggca gatgcattaa catcaactgg cggtgtgaca acgacaatga ctgtggagac
     3361 aatagtgacg aagccggctg cagtcactcc tgctccagta cccagttcaa gtgcaacagt
     3421 ggcagatgca tccccgagca ctggacttgt gacggggaca acgactgtgg agactacagt
     3481 gatgagaccc atgcaaactg taccaaccag gccacaagac ctcctggtgg ctgccactca
     3541 gatgagttcc agtgccggct agatggcctg tgcatccccc tgcggtggcg ctgtgatggg
     3601 gacactgact gcatggactc tagtgatgag aagggctgtg agggggtgac ccacgtctgt
     3661 gatccgaatg tcaagtttgg ctgcaaggac tcagctcggt gcatcagcaa agcatgggtg
     3721 tgtgatggtg acagtgactg tgaagataac tcagacgagg agaactgtga ggccctggcc
     3781 tgcaggccac cgtcacatcc ctgtgccaac aacacctccg tctgcctgtc ccctgataag
     3841 ctgtgtgatg gcaaggatga ctgtggagat ggctccgacg agggcgagct ctgtgaccag
     3901 tgttctctga ataatggtgg ctgtagtcac aactgctcgg tggcccctgg tgaaggcatt
     3961 gtgtgctctt gccctctggg catggagctg ggacctgaca accacacctg ccagatccag
     4021 agctactgtg ccaagcacct caaatgcagc cagaagtgcg accagaacaa gttcagtgtg
     4081 aagtgctcct gctatgaggg ctgggtcttg gaaccagacg gggagagctg ccgcagcctg
     4141 gatcccttca aaccgttcat catcttctcc aaccgccatg agatcagacg cattgacctt
     4201 cacaaggggg actacagcgt cctagtgccc ggcctgcgca acaccattgc cctggacttt
     4261 cacctcagcc agagtgccct ctactggacc gatgtggtag aggacaagat ctaccgtggg
     4321 aagctgctgg acaacggagc actgaccagc tttgaggtgg tgattcagta tggcttggcc
     4381 accccagagg gcctggctgt agactggata gcaggcaaca tctactgggt ggaaagcaac
     4441 ctggaccaga tcgaggtggc caagctggat ggaaccctcc gaaccactct gctggcgggc
     4501 gacattgagc acccaagggc aattgctctg gaccctcggg atgggattct gttttggaca
     4561 gattgggatg ccagtctgcc ccgaattgaa gcagcatcca tgagtggggc cgggcgccga
     4621 accatccacc gagagacagg ctctgggggt tggcccaacg ggctcaccgt ggactacctg
     4681 gagaagcgca tcctctggat cgatgccagg tcagatgcta tctactcagc ccgttatgac
     4741 ggctccggcc acatggaggt gctccggggg catgagttcc tgtctcaccc gtttgccgtg
     4801 acactgtatg gtggggaggt gtactggact gactggcgaa caaacacact ggctaaggcc
     4861 aacaagtgga ccggccacaa tgtcactgtg gtacagagga ccaacaccca gcccttcgac
     4921 ctgcaggtgt atcacccttc tcggcagccc atggctccaa acccatgtga ggccaatggg
     4981 ggccggggtc cctgttccca cctgtgcctc atcaactaca accggacggt ctcctgtgct
     5041 tgtccccatc tcatgaaact ccacaatgac aacaccacct gctacgagtt taagaagttc
     5101 ctgctgtacg cacgtcagat ggagatccgg ggtgtggacc tggacgcccc gtactacaat
     5161 tacatcatct ccttcacggt gcccgacatt gacaatgtca cagtgctgga ctatgatgcc
     5221 cgagagcagc gagtttactg gtctgacgtg cgaacccaag ccatcaaacg ggcattcatc
     5281 aacggcacag gcgtggagac cgttgtctct gcagacttgc caaatgccca tgggctggct
     5341 gtggactggg tgtcccgaaa tctgttctgg accagttatg acaccaacaa gaagcagatt
     5401 aacgtggccc ggctagatgg ctccttcaag aatgcggtgg tgcagggcct ggagcagccc
     5461 cacggcctgg ttgtccaccc gcttcgtggc aagctctact ggacggacgg ggacaatatc
     5521 agcatggtca acatggatgg gagcaaccgg actctgctct tcagtggcca gaagggccct
     5581 gtgggcttag ccattgactt ccctgagagc aaactctact ggatcagctc tgggaaccac
     5641 acgatcaacc gttgcaatct ggatgggagt gagctggagg tcatcgacac catgcgtagc
     5701 cagctgggca aggccactgc cctggccatc atgggggaca agctgtggtg ggcagatcag
     5761 gtgtcagaga agatgggcac atgcaacaag gccgacggct ccgggtcggt ggtgctgcgg
     5821 aacagcacca cgttggttat gcacatgaag gtgtatgatg agagcatcca gctagagcat
     5881 gagggcacca acccctgcag tgtcaacaat ggagactgct cccagctctg cctgccaaca
     5941 tcagagacaa ctcgctcctg tatgtgtaca gctggttaca gcctccggag cggacagcag
     6001 gcctgtgagg gtgtgggttc ttttctcctg tattctgtcc atgagggaat tcgggggatc
     6061 ccactggatc ccaatgacaa gtcggatgcc ctggtcccag tgtcgggaac gtcactggct
     6121 gttggaatcg acttccatgc tgaaaatgac actatttatt gggtggacat gggtctaagc
     6181 accatcagca gggccaagcg tgaccagaca tggcgagagg atgtggtgac caatggcatt
     6241 ggccgtgtgg agggcatcgc ggtggactgg atcgcaggca acatctactg gacagaccag
     6301 ggctttgatg tcatcgaggt tgcccgactc aatggatctt tccgttatgt ggtcatttcc
     6361 cagggtctag acaagcctcg ggccatcact gtccacccag agaaggggta cttgttctgg
     6421 actgagtggg gtcactaccc acggattgag cggtctcgcc ttgacggcac agagagagtg
     6481 gtgctggtta atgtcagcat cagctggccc aatggcatct cagtagacta tcagggcggc
     6541 aagctctact ggtgtgatgc ccggatggac aagatcgaac gtatcgatct ggagacgggt
     6601 gagaaccgtg aggtggtcct gtccagtaac aacatggaca tgttctctgt gtctgtgttt
     6661 gaggatttca tctactggag tgacagaact cacgccaacg gctccatcaa gcgtggatgc
     6721 aaagacaatg ccacagactc cgtgcctctg agaacgggca ttggcgtgca gcttaaagac
     6781 atcaaggtct tcaacaggga caggcagaag ggtaccaacg tgtgcgcagt agccaacggt
     6841 gggtgccagc aactatgctt atatcggggt ggtggacagc gagcctgtgc ctgtgcccat
     6901 ggaatgctgg cagaagatgg ggcttcgtgc cgagagtatg ctggctacct gctctattca
     6961 gagcgtacca tcctcaagag catccacctg tcagatgagc gtaacctcaa cgcaccggtg
     7021 cagcctttcg aagaccctga gcacatgaaa aatgtcatcg ccctagcttt tgactaccgg
     7081 gcaggcacct ccccagggac ccctaaccgc atcttcttca gtgacatcca ctttgggaat
     7141 atccagcaga tcaatgacga tggctcgggg aggaccacca tcgtggaaaa tgtgggctct
     7201 gtggaaggcc tggcctatca cagaggctgg gacacactgt actggacaag ctacacgaca
     7261 tccaccatca cccgccatac cgtggaccag actcgcccag gggcctttga gagggagacg
     7321 gtcatcacca tgtctggaga tgatcaccca agggcatttg tgctggacga gtgccagaac
     7381 ctgatgttct ggaccaattg gaatgagctt cacccaagca tcatgcgggc agccctatct
     7441 ggagccaacg tcctgaccct catcgagaag gacatccgca cacccaatgg gttggccatc
     7501 gaccaccggg ccgagaagct ttacttctcg gacgccacat tggacaagat cgagcgctgt
     7561 gaatatgatg gctcccatcg ctatgtgatc ctgaagtcag agcccgtcca cccctttggg
     7621 ttggcagtgt acggagagca cattttctgg actgactggg tgcggcgggc tgtgcagcgg
     7681 gccaacaagt atgtgggcag tgacatgaag ctgctgcgag tagacatccc ccagcagccc
     7741 atgggcatca tcgctgtggc caatgacacc aacagctgtg aactttcccc ctgccgtatc
     7801 aacaatggcg gctgtcagga tctgtgtctg ctcacccacc aaggccatgt caactgttcc
     7861 tgtcgagggg gccggatcct ccaggaggat ttcacctgcc gggctatgaa ctcctcttgt
     7921 cgggcacaag atgagttcga gtgcgccaat ggagagtgta tcagcttcag cctcacctgt
     7981 gatggtgtct cccactgcaa ggacaagtct gatgagaagc cctcctactg caactcacgc
     8041 cgctgcaaga agactttccg ccagtgcaac aacggccgct gtgtatctaa catgctgtgg
     8101 tgcaatgggg tggacgactg tggcgatggc tccgatgaga ttccttgcaa caagaccgcc
     8161 tgcggcgtgg gtgaattccg ctgccgggat gggtcctgca tcgggaactc cagtcgctgc
     8221 aaccagtttg tggattgtga ggatgcctcg gatgagatga attgcagcgc caccgactgc
     8281 agcagttatt tccgcctggg cgtgaaaggt gtcctcttcc agccttgcga gcggacatcc
     8341 ctctgctatg cacccagctg ggtgtgcgat ggtgccaacg actgtggaga ctacagtgac
     8401 gagcgtgact gcccaggtgt gaagcgccca cggtgcccac tcaattactt tgcctgcccc
     8461 agcgggcgct gcatccccat gagctggacg tgtgacaaag aggacgattg tgagaacggc
     8521 gaggatgaga cccactgcaa caagttctgc tcggaggccc agtttgagtg ccagaaccac
     8581 cggtgtatct ccaagcagtg gctgtgtgac ggcagcgatg actgcgggga cggctccgat
     8641 gaggcagctc actgtgaagg caagacttgc ggcccctcct ccttctcctg tcctggcacc
     8701 cacgtgtgtg tccccgagcg ctggctctgt gacggtgaca aggactgtgc tgatggcgcg
     8761 gatgagagca tctcagctgg ctgcctgtac aacagcacct gtgacgaccg tgagttcatg
     8821 tgccagaacc gcctgtgtat tcccaagcat tttgtgtgtg accatgaccg cgactgtgcc
     8881 gatggctctg atgaatcccc tgagtgtgaa tacccaacct gcggccccaa cgaattccgc
     8941 tgcgccaatg ggcgttgtct gagctcccgc cagtgggagt gtgatgggga gaatgactgt
     9001 catgaccaca gtgatgaggc tcccaagaac ccacactgca caagcccaga gcacaaatgc
     9061 aatgcctcat cacagttcct gtgcagcagc gggcgctgcg tggctgaggc gttgctctgc
     9121 aatggccagg acgactgcgg ggatggttca gacgaacgcg ggtgccacgt caacgagtgt
     9181 ctcagccgca agctcagtgg ctgcagtcag gactgcgagg acctcaagat aggctttaag
     9241 tgccgctgtc gccctggctt ccggctaaag gatgatggca gaacctgtgc tgatgtggac
     9301 gagtgcagca ccaccttccc ctgcagccag ctctgcatca acacccatgg cagttacaag
     9361 tgtctgtgtg tggagggcta tgcaccccgc ggtggtgacc cccacagctg caaagctgtg
     9421 accgatgagg agccgtttct catctttgcg aaccggtact acctgcgcaa gctcaacttg
     9481 gacggctcca actacacact gcttaagcag ggcctgaaca atgcagttgc cttggacttt
     9541 gactaccggg ggcagatgat ctactggaca gacgtgacga cccagggcag catgatccga
     9601 aggatgcacc tcaatggtag caacgtgcag gttctgcacc ggacaggcct tagtaacccc
     9661 gatgggctgg ctgtggactg ggtgggtggc aacctgtact ggtgtgacaa gggcagagac
     9721 actattgagg tgtccaagct caacggggcc tatcggacag tgctggtcag ctctggcctc
     9781 cgtgagccca gagctcttgt ggtggatgta cagaacgggt acctctactg gacagactgg
     9841 ggtgaccact cactgatcgg tcggattggc atggatgggt ctggccgcag tatcattgtg
     9901 gacactaaga tcacatggcc caatggcctg actgtggact acgtcacgga gcgcatctac
     9961 tgggctgatg cccgtgagga ctacatcgag tttgccagcc tggatggatc caaccgccat
    10021 gttgtgctga gccaagacat cccacacatc tttgcactga ccctatttga ggattacgtc
    10081 tactggaccg actgggaaac aaagtccatc aaccgggccc ataagaccac gggtgccaac
    10141 aaaaccctcc tcatcagcac cctgcaccgg cccatggacc tacatgtctt ccacgccctg
    10201 cgccagccag atgtgcccaa tcacccctgc aaagtcaaca acggtggctg cagcaacctg
    10261 tgcctgctgt ctcctggggg tggtcacaaa tgcgcctgcc ccaccaactt ctatctgggt
    10321 ggtgacggcc gtacctgtgt gtctaactgc acagcaagcc agtttgtatg caagaatgac
    10381 aagtgcatcc ccttctggtg gaagtgtgac actgaggacg attgtgggga ccactcagac
    10441 gagcctccag actgtcccga gttcaagtgc cgcccaggcc agttccagtg ctccaccggc
    10501 atctgcacca accctgcctt catctgtgat ggggacaatg actgccaaga caatagtgac
    10561 gaggccaact gtgacatcca cgtctgcttg cccagtcaat tcaagtgcac caacaccaac
    10621 cgctgtatcc ctggcatctt ccgttgcaac gggcaggaca actgtgggga cggcgaggat
    10681 gaacgggatt gccctgaggt gacctgtgcc cccaaccagt tccagtgctc tatcaccaag
    10741 cgctgcatcc cccgagtctg ggtctgcgac agggacaatg actgtgtgga cggaagtgat
    10801 gaacctgcca actgcaccca gatgacctgc ggggtggatg agttccgctg caaggactcg
    10861 ggccgctgca tccctgcacg ctggaagtgt gacggagaag acgactgtgg ggacggctca
    10921 gatgagccca aggaagagtg tgatgagcgc acctgtgagc cataccagtt ccgctgcaaa
    10981 aacaaccgct gtgtgccagg ccgctggcag tgtgactatg acaatgactg tggagataac
    11041 tcagacgagg agagctgcac acctcggccc tgctctgaga gtgaattttc ctgtgccaac
    11101 ggccgctgca ttgctgggcg ctggaagtgt gacggcgatc atgactgtgc cgacggctcc
    11161 gatgagaaag actgcacccc ccgctgtgat atggaccagt tccagtgcaa gagtggtcac
    11221 tgcatccccc tgcgctggcg ctgtgatgcg gatgctgact gtatggacgg cagtgatgag
    11281 gaagcctgcg gcactggggt gaggacctgc cccttggatg aatttcaatg taacaacacc
    11341 ctgtgcaagc cactggcctg gaagtgtgac ggagaggacg actgtggaga caactcagat
    11401 gagaaccctg aggaatgcac ccggttccag tgccctccta accgaccctt ccgctgcaag
    11461 aatgaccgtg tctgcctgtg gattgggcgc cagtgtgacg gcaccgacaa ctgtggggat
    11521 gggactgacg aggaggactg tgagcccccc acagcccaga acccccactg caaagacaag
    11581 aaggagttcc tgtgccggaa ccagcgctgt ctgtcatcct cgctgcgctg taacatgttt
    11641 gatgactgtg gcgatggctc tgatgaagaa gactgcagca tagaccccaa gctgaccagc
    11701 tgtgccacca atgccagcat gtgtggggac gaagcacgtt gtgtgcgcac cgagaaggct
    11761 gcctactgtg cctgccgccc gggcttccat actgtgccgg gccagcccgg atgccaggac
    11821 atcaacgagt gcctgcgctt cggcacctgc tctcagctct gcaacaatac caagggaggc
    11881 cacctctgca gctgtgcacg caacttcatg aagacacaca atacctgcaa agctgaaggc
    11941 tccgagtacc aggtgctata catcgctgat gacaacgaga tccgaagctt gttcccgggg
    12001 cacccccact cagcctatga gcaggccttc cagggtgacg agagtgtccg catagatgcc
    12061 atggacgtcc atgtcaaggc cggccgtgtc tactggacta actggcacac gggcactatc
    12121 tcctatagga gcctaccccc tgctgcccct cctaccactt ccaaccgtca ccggaggcag
    12181 atcgaccgtg gagtcaccca cctcaatatt tcagggctga agatgccgag gggcattgcc
    12241 atcgactggg tggctgggaa tgtgtactgg accgactccg gccgagacgt gattgaggtg
    12301 gcgcaaatga agggagagaa ccgcaagacg ctcatctcgg gcatgattga tgagccccac
    12361 gccatcgtgg tggacccact gaggggcacc atgtactggt cagactgggg gaaccacccc
    12421 aagattgaaa cagccgcgat ggatgggacc ctacgggaga ccctcgtgca agacaacatt
    12481 cagtggccca caggtctggc cgtcgactat cacaatgaac ggctgtactg ggcggatgcc
    12541 aaactatcgg tcatcggcag catccggctc aacggcaccg accccattgt ggctgttgac
    12601 agtaaacgag gcctgagtca ccccttcagc atcgacgtgt tcgaggacta catctatggc
    12661 gtcacttaca tcaacaaccg tgtcttcaag atccacaagt ttggacacag ccccttgatc
    12721 aacctgacag ggggcctgag ccacgcctct gatgtggtcc tgtaccatca acacaagcag
    12781 cctgaagtga ctaacccctg tgaccgcaag aaatgtgaat ggctgtgtct gctgagcccc
    12841 agtgggcctg tctgcacctg tcccaatgga aagaggctgg acaatggcac ctgtgtgcct
    12901 gtgccctctc cgacaccccc tccagatgcc cctaggcctg gaacctgtac cctgcagtgc
    12961 ttcaatggtg gtagctgttt cctcaatgct cggaggcagc ccaagtgccg ctgccagccc
    13021 cgttacacag gcgataagtg tgagctggac cagtgctggg aatactgtca caacggaggc
    13081 acctgtgcag cctccccatc tggcatgccc acgtgccgct gtcccacagg cttcacaggc
    13141 cccagatgca cccagcaggt gtgtgcaggc tactgtgcta acaacagcac ctgcaccgtc
    13201 aaccagggta accagcccca gtgccgatgt ctacctggct tcctgggtga ccgttgccag
    13261 taccggcagt gctcaggctt ctgtgagaac tttggcacct gtcagatggc cgccgatggc
    13321 tcccgacaat gtcgatgcac tgtctacttt gagggaacga ggtgtgaggt gaacaagtgt
    13381 agtcgctgtc tccagggagc ctgtgtggtc aataagcaga cgggagatgt cacctgcaac
    13441 tgcactgatg gccgggtagc tcccagttgt ctgacctgca tcgaccactg tagcaatggt
    13501 ggctcctgca ccatgaacag caagatgatg ccagagtgcc agtgcccacc ccatatgaca
    13561 ggaccccggt gcgaggagca ggttgtcagt cagcaacagc ctgggcatat gacctccatc
    13621 ctgatccctc tgctgctgct gctcctgctg ctgctggtgg caggcgtggt gttctggtat
    13681 aagcggcgag tccgaggggc taagggcttc cagcaccagc ggatgaccaa tggggccatg
    13741 aatgtggaaa tcggaaaccc tacctacaag atgtatgaag gtggagagcc cgacgatgtg
    13801 gggggcctcc tggatgctga ttttgccctt gaccctgaca agcctaccaa cttcaccaac
    13861 ccagtgtatg ccacgctcta catggggggt catggcagcc gccactccct ggccagcacg
    13921 gacgagaagc gagaactgct gggccgggga cctgaagatg agatagggga tcccttagca
    13981 tagggccctg ccccaacgga cgtccccaga aagcccctgc cacacgagtc tttcaatgag
    14041 ccctctcccc agccagccct tctccggccc tgccggatgt acaaatgtaa aaatgaagga
    14101 attacttttt atatgtgagt gagcaagcac agtattatct ctttgcattt cctttctgcc
    14161 tgctcctcgg catcccctcc ccccatgctg ccttgagggg gcagggaggg ctctgtggct
    14221 caaaggtatg aaggagtcca catacgttcc cttaccccgg gaagctggcg gcacagcctc
    14281 tcgcctgtac aagacactca acagggctcc agtgtcccag ctttcctttc ctggggttag
    14341 ttctggggag gtggagttct ctgctgaacc tgtctggaat atctggctct agctgaggta
    14401 ggagtatttt ttagttgagg gaagtcaccc caagccccag ctcccacttt taggggcacg
    14461 tctgggatgg ccatgctcag tatcccttcc agacaggtct ttgcctctcc agtgccccct
    14521 ctgtggctcc tagggctgaa cacattcttt ggtaactgtc ccccagtctc ccctcccctg
    14581 aggaccagga agaattgggg cacaccaagg aagggcaagt gggcagcccc attttgggga
    14641 cgtgaacgtt ttaataattt ttgctgaatt cctttacaac taaataacac agatattgtt
    14701 ataaataaaa ttgt
//
LOCUS       NR_031945                 82 bp    RNA     linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus microRNA 320a (Mir320a), microRNA.
ACCESSION   NR_031945
VERSION     NR_031945.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 82)
  AUTHORS   Liang,S., Cao,W., Zhuang,Y., Zhang,D., Du,S. and Shi,H.
  TITLE     Suppression of microRNA-320 Induces Cerebral Protection Against
            Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB Axis
  JOURNAL   Physiol Res 73 (1), 127-138 (2024)
   PUBMED   38466011
  REMARK    GeneRIF: Suppression of microRNA-320 Induces Cerebral Protection
            Against Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB
            Axis.
REFERENCE   2  (bases 1 to 82)
  AUTHORS   Liu,Y., Wang,T., Lai,H., Shen,J. and Gao,F.
  TITLE     Inhibiting MiR-320a promotes myocardial apoptosis in myocardial
            infarction rats through activating VEGF pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 170-175 (2023)
   PUBMED   38063099
  REMARK    GeneRIF: Inhibiting MiR-320a promotes myocardial apoptosis in
            myocardial infarction rats through activating VEGF pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 82)
  AUTHORS   Lu,Z., Zhang,Y. and Li,Y.
  TITLE     LncRNA FTX ameliorates neuropathic pain by targeting miR-320a in a
            rat model of chronic constriction injury
  JOURNAL   Folia Neuropathol 61 (3), 291-300 (2023)
   PUBMED   37818689
  REMARK    GeneRIF: LncRNA FTX ameliorates neuropathic pain by targeting
            miR-320a in a rat model of chronic constriction injury.
REFERENCE   4  (bases 1 to 82)
  AUTHORS   Wang,B., Yin,Z., Lin,Y., Deng,X., Liu,F., Tao,H., Dong,R., Lin,X.
            and Bi,Y.
  TITLE     Correlation between microRNA-320 and postoperative delirium in
            patients undergoing tibial fracture internal fixation surgery
  JOURNAL   BMC Anesthesiol 22 (1), 75 (2022)
   PUBMED   35317728
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 82)
  AUTHORS   Gong,X., Zhang,J., Ge,C., Yi,Y., Dai,S., Fan,G., Li,C., Zhang,Y.,
            Wang,H. and Xu,D.
  TITLE     miRNA320a-3p/RUNX2 signal programming mediates the
            transgenerational inheritance of inhibited ovarian estrogen
            synthesis in female offspring rats induced by prenatal
            dexamethasone exposure
  JOURNAL   Pharmacol Res 165, 105435 (2021)
   PUBMED   33485996
  REMARK    GeneRIF: miRNA320a-3p/RUNX2 signal programming mediates the
            transgenerational inheritance of inhibited ovarian estrogen
            synthesis in female offspring rats induced by prenatal
            dexamethasone exposure.
REFERENCE   6  (bases 1 to 82)
  AUTHORS   Linsen,S.E., de Wit,E., de Bruijn,E. and Cuppen,E.
  TITLE     Small RNA expression and strain specificity in the rat
  JOURNAL   BMC Genomics 11, 249 (2010)
   PUBMED   20403161
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 82)
  AUTHORS   Xia,H.F., Jin,X.H., Song,P.P., Cui,Y., Liu,C.M. and Ma,X.
  TITLE     Temporal and spatial regulation of miR-320 in the uterus during
            embryo implantation in the rat
  JOURNAL   Int J Mol Sci 11 (2), 719-730 (2010)
   PUBMED   20386663
  REMARK    GeneRIF: The miRNA miR-320 could be detected differentially in the
            rat uterus during the peri-implantation period.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 82)
  AUTHORS   Ren,X.P., Wu,J., Wang,X., Sartor,M.A., Jones,K., Qian,J.,
            Nicolaou,P., Pritchard,T.J. and Fan,G.C.
  TITLE     MicroRNA-320 is involved in the regulation of cardiac
            ischemia/reperfusion injury by targeting heat-shock protein 20
  JOURNAL   Circulation 119 (17), 2357-2366 (2009)
   PUBMED   19380620
REFERENCE   9  (bases 1 to 82)
  AUTHORS   Landgraf,P., Rusu,M., Sheridan,R., Sewer,A., Iovino,N., Aravin,A.,
            Pfeffer,S., Rice,A., Kamphorst,A.O., Landthaler,M., Lin,C.,
            Socci,N.D., Hermida,L., Fulci,V., Chiaretti,S., Foa,R.,
            Schliwka,J., Fuchs,U., Novosel,A., Muller,R.U., Schermer,B.,
            Bissels,U., Inman,J., Phan,Q., Chien,M., Weir,D.B., Choksi,R., De
            Vita,G., Frezzetti,D., Trompeter,H.I., Hornung,V., Teng,G.,
            Hartmann,G., Palkovits,M., Di Lauro,R., Wernet,P., Macino,G.,
            Rogler,C.E., Nagle,J.W., Ju,J., Papavasiliou,F.N., Benzing,T.,
            Lichter,P., Tam,W., Brownstein,M.J., Bosio,A., Borkhardt,A.,
            Russo,J.J., Sander,C., Zavolan,M. and Tuschl,T.
  TITLE     A mammalian microRNA expression atlas based on small RNA library
            sequencing
  JOURNAL   Cell 129 (7), 1401-1414 (2007)
   PUBMED   17604727
REFERENCE   10 (bases 1 to 82)
  AUTHORS   Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and
            Enright,A.J.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
   PUBMED   16381832
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from JAXUCZ010000015.1.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582419.2161530.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000015.1  51926088-51926169
FEATURES             Location/Qualifiers
     source          1..82
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..82
                     /gene="Mir320a"
                     /gene_synonym="Mir320; rno-mir-320"
                     /note="microRNA 320a"
                     /db_xref="GeneID:100314065"
                     /db_xref="miRBase:MI0000972"
                     /db_xref="RGD:2325539"
     precursor_RNA   1..82
                     /gene="Mir320a"
                     /gene_synonym="Mir320; rno-mir-320"
                     /product="microRNA 320a"
                     /db_xref="GeneID:100314065"
                     /db_xref="miRBase:MI0000972"
                     /db_xref="RGD:2325539"
     exon            1..82
                     /gene="Mir320a"
                     /gene_synonym="Mir320; rno-mir-320"
                     /inference="alignment:Splign:2.1.0"
     ncRNA           16..37
                     /ncRNA_class="miRNA"
                     /gene="Mir320a"
                     /gene_synonym="Mir320; rno-mir-320"
                     /product="rno-miR-320-5p"
                     /db_xref="miRBase:MIMAT0017168"
                     /db_xref="GeneID:100314065"
                     /db_xref="miRBase:MI0000972"
                     /db_xref="RGD:2325539"
     ncRNA           48..69
                     /ncRNA_class="miRNA"
                     /gene="Mir320a"
                     /gene_synonym="Mir320; rno-mir-320"
                     /product="rno-miR-320-3p"
                     /db_xref="miRBase:MIMAT0000903"
                     /db_xref="GeneID:100314065"
                     /db_xref="miRBase:MI0000972"
                     /db_xref="RGD:2325539"
ORIGIN      
        1 gcctcgctgt cctccgcctt ctcttcccgg ttcttcccgg agtcgggaaa agctgggttg
       61 agagggcgaa aaaggatatg gg
//
LOCUS       NM_001436446            1980 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 6, mRNA.
ACCESSION   NM_001436446 XM_039080714
VERSION     NM_001436446.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 1980)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 1980)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_039080714.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.24266.1,
                                           SRR26360186.182801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JAXUCZ010000008.1  117870975-117871213
            240-318             JAXUCZ010000008.1  117880565-117880643
            319-476             JAXUCZ010000008.1  117894634-117894791
            477-597             JAXUCZ010000008.1  117897631-117897751
            598-728             JAXUCZ010000008.1  117901968-117902098
            729-1980            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1980
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..239
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..318
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    249..251
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            319..476
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..902
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423375.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     321..890
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    333..857
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    333..857
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(333..335,420..422,429..434,441..443,447..449,
                     453..455,480..482,492..497,501..509,516..518,522..524,
                     534..536)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(333..335,420..422,429..434,441..443,447..449,
                     453..455,480..482,492..497,501..509,516..518,522..524,
                     534..536)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    354..377
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    354..377
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(363..380,420..425,429..431,495..500,672..674,
                     678..680,801..806)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(363..380,420..425,429..431,495..500,672..674,
                     678..680,801..806)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(387..389,393..407,444..449,453..461,474..482,
                     807..812,822..827,834..836)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(387..389,393..407,444..449,453..461,474..482,
                     807..812,822..827,834..836)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(420..422,426..428,432..437,507..518,525..527,
                     534..536,600..602)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(420..422,426..428,432..437,507..518,525..527,
                     534..536,600..602)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    420..446
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    420..446
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    420..446
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(429..434,501..503,516..518,522..527,531..536,
                     543..545,633..638,642..644)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(429..434,501..503,516..518,522..527,531..536,
                     543..545,633..638,642..644)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    429..431
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    429..431
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(435..437,513..527,534..536,609..611,621..623,
                     633..635)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(435..437,513..527,534..536,609..611,621..623,
                     633..635)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(435..440,513..518,522..527,534..536)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(435..440,513..518,522..527,534..536)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    495..506
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    495..506
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    501..554
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    504..557
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    504..557
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    669..680
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    669..680
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    798..806
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    798..806
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    882..884
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    888..890
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            477..597
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..728
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1980
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcagggc tgcgccgggc tgggcggggg ctcccggccg gcccgcgacc gcgctggggt
       61 agcctaccac tgcgaagcgc gtgtggctgt cgggagttga aataggcaag aaactcttgt
      121 acaactccat tttgcctttt acattgaacg aggatcatta atcaccgttt tataccgtgt
      181 gaagacagtg aggctttggg tggattttct gttttctttg ccgtattatt ggaagttgtc
      241 cttgcatcta agaagtccca ggtactttgt acaactgcat cccagaagct gagtttcttc
      301 agcaccttca taaggtattg atggctgcca tcaggaagaa actggtgatt gttggtgatg
      361 gagcttgtgg taagacatgc ttgctcatag tcttcagcaa ggaccagttc ccagaggttt
      421 atgtgcccac ggtgtttgaa aactatgtgg cagatattga agtggacggg aagcaggtag
      481 agttggcttt atgggacaca gctggacagg aagattatga ccgtctgagg cctctctcct
      541 acccagacac tgatgttata ctgatgtgtt tttccatcga cagccctgat agtttagaaa
      601 acatcccaga aaaatggact ccagaagtca agcatttctg tccaaatgtg cccatcatcc
      661 tagttgggaa caagaaggat cttcggaatg atgagcacac aaggcgggag ttagccaaaa
      721 tgaagcagga gccggtaaaa cctgaagaag gcagagatat ggcaaacagg attggcgctt
      781 ttgggtacat ggagtgttca gcaaagacca aagacggagt gagagaggtt tttgagatgg
      841 ccacgagagc tgctctgcaa gctagacgcg ggaagaaaaa gtcggggtgc ctcatcttgt
      901 gaagccttgt gacgcgcagc ctcatgcggt taatttgaag tgctgtttat taatcttagt
      961 gtatgattac tggccttttc atttatctat aatttaccta agattacaaa tcagaagtca
     1021 tcttgctacc agtatttaga agccaaccat gattattaat gatgtccagc ctgtctgacc
     1081 agccagggtc cttctgacac tgctctaacg ccctctctgc actccacctg acaccaggcg
     1141 ctcattcaaa gaatttctta acttcctgct tctttctaga aagagaaaca gttggtaact
     1201 tttgtgaatt aggctgtaac tactttataa ctaacatgtc ctgcctattt tctgtcagct
     1261 gcgaggaact ctggtgagtc actacttcag agctttactc cttaacagat tccattggca
     1321 gagctctggg gtgggcaccc agtgtttgga aacttgatca gccagaaagg cccaagtcca
     1381 cgcagctgtg gcagagttac agttctgtgg tctcatgtta gttaccttat agttactgtg
     1441 taattagtgc cacttaatgt atgttaccaa aaataaatat atctacccca gactagatgt
     1501 agtatttttt gtataattgg atttcctaat tctgatattt gtcattccca cagaaagtgt
     1561 attgcttttt ttttttttta agaaagtatt tggaaataaa gtcagatgga aaattcattt
     1621 ttaaaattcc cattttgtca ctttctctga taaaatatgg ccatatctcc cctatttagc
     1681 cctatatatc attccagtgc ccctttccag actggactga ggaaatagga attggtttca
     1741 tgcctgaggc tgttagactt tggaggtggc atagcctttc tcacctggac tgcagggcct
     1801 ggctctaagt cacagtgctc ctttctccac actgttatcc aagtcgcctc ccagaggagc
     1861 caccagttct tatgggtggc aatgggtggg tgggtggggg gtctcctctc tccagctgac
     1921 taaacttttt tctgtaccag ttaatttttc caactaatag aataaaggca gttttctaaa
//
LOCUS       NM_001436431            3396 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 2, mRNA.
ACCESSION   NM_001436431 XM_063266245
VERSION     NM_001436431.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3396)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3396)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3396)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3396)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3396)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3396)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3396)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3396)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3396)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3396)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.44138.1,
                                           SRR26360181.1631764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-472             JAXUCZ010000008.1  28220002-28220231
            473-650             JAXUCZ010000008.1  28220683-28220860
            651-798             JAXUCZ010000008.1  28223540-28223687
            799-890             JAXUCZ010000008.1  28224972-28225063
            891-986             JAXUCZ010000008.1  28225440-28225535
            987-1098            JAXUCZ010000008.1  28226074-28226185
            1099-1196           JAXUCZ010000008.1  28226611-28226708
            1197-1308           JAXUCZ010000008.1  28227262-28227373
            1309-1419           JAXUCZ010000008.1  28227460-28227570
            1420-1619           JAXUCZ010000008.1  28228703-28228902
            1620-1787           JAXUCZ010000008.1  28229217-28229384
            1788-1913           JAXUCZ010000008.1  28230380-28230505
            1914-2090           JAXUCZ010000008.1  28230664-28230840
            2091-2247           JAXUCZ010000008.1  28230937-28231093
            2248-2301           JAXUCZ010000008.1  28231210-28231263
            2302-2556           JAXUCZ010000008.1  28234392-28234646
            2557-2685           JAXUCZ010000008.1  28235346-28235474
            2686-3396           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3396
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2822
                     /gene="Ilf3"
                     /note="isoform 2 is encoded by transcript variant 2; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 2"
                     /protein_id="NP_001423360.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSV
                     FPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKF
                     QGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFG
                     MGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNS
                     ATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGG
                     QQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQDYSGSGGRSGGNSYGSSGSSYNTGSH
                     GGYGAGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMN
                     YQYR"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1797..2012
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1797..2012
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1818..1820,1824..1829,1836..1838,1875..1877,
                     1884..1892,1902..1904,1950..1961)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1818..1820,1824..1829,1836..1838,1875..1877,
                     1884..1892,1902..1904,1950..1961)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            243..472
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..650
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..798
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..890
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..986
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1098
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1196
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1308
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1619
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1787
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1913
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2090
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2247
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2301
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2556
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2685
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3396
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tgcgtcccat gagaattttt gtgaatgatg atcgccatgt gatggcaaag cattcttcag
      301 tatacccaac acaagaggag ctggaggctg tacagaacat ggtgtcccac actgagcggg
      361 ccctcaaggc tgtctctgac tggattgatg agcaggagaa aggcaacagc gagctctctg
      421 aagcagaaaa tatggacaca cccccagatg atgagagcaa agaaggggct ggggaacaga
      481 aggcggaaca catgactagg accctgaggg gcgtgatgcg ggtcggcctg gtagccaagg
      541 gtcttctgct caagggggac ttggatctgg agctggttct gctctgtaag gagaagccca
      601 caactgccct tctggacaag gtggctgaca acctggccat ccagcttact actgtaacag
      661 aagacaagta tgaaatactc caatctgtgg atgatgctgc gattgtgata aaaaacacaa
      721 aagagccccc cttgtccttg accatccatc tgacctcccc tgttgtcaga gaagaaatgg
      781 agaaagtatt agctggagaa acgctatcag tcaacgaccc cccggacgtt ctggacaggc
      841 agaaatgcct tgctgccttg gcgtccctcc gacacgccaa gtggttccag gctagagcca
      901 atgggctgaa gtcatgtgtc attgtcatcc gtgtcctaag ggacttgtgt acccgagtgc
      961 ccacctgggg tcctctcaga ggatggcctc tggagctgct gtgtgagaag tccatcggca
     1021 ctgccaatag gccaatgggt gctggtgaag ccctgcggag agtactggag tgcctggctt
     1081 ccggcatcgt aatgccagat ggttctggca tttatgaccc ttgtgaaaaa gaagccactg
     1141 atgctattgg gcatctagac agacagcaac gggaagatat cacacagagt gcgcagcatg
     1201 ctctgcggct tgctgccttt ggccagctcc ataaagtact gggaatggac ccactgcctt
     1261 ccaaaatgcc caagaaacca aagaacgaga acccggtgga ctatactgtt caaatccccc
     1321 ccagcaccac ctacgccatc acacccatga aacgccctat ggaagaagat ggggaggaga
     1381 agtctcccag caaaaagaaa aagaagatcc agaagaaaga ggagaaggct gagcctcccc
     1441 aagctatgaa tgccctgatg aggttaaacc agctgaagcc agggctacag tacaagctga
     1501 tctcccagac gggtcctgtt cacgctccca tcttcaccat gtctgtggag gtagacggca
     1561 gtacctttga ggcctcaggg ccatctaaaa agaccgccaa gctacatgtg gctgtgaagg
     1621 tgttacagga catgggattg ccaacaggcg ctgaaggcag agactccagc aagggggagg
     1681 actctgctga ggagtcagat gggaagccag cagtagtggc cccaccccct gtggtggaag
     1741 cagtctccaa ccccagttct gtcttccctt cagatgccac tactgagcag gggccgattt
     1801 tgactaagca cggcaagaat cctgtaatgg agcttaatga gaagagacgt ggcctcaaat
     1861 atgagctcat ttctgagaca gggggcagcc acgacaaacg gtttgttatg gaggttgagg
     1921 tggacggaca gaagtttcaa ggtgctggct caaacaaaaa ggtagcaaag gcttatgctg
     1981 cacttgccgc attagagaag cttttccctg acgcccctct tgctcttgaa gccaacaaga
     2041 agaaaagagc ccctgtgcct gtccgaggcg gacccaaatt tgctgccaag ccacataacc
     2101 ctggctttgg catgggaggc cccatgcata atgaagcgcc cccacctccc aacatccgag
     2161 gtcggggccg aggaggtaac atccgagggc gaggacgggg gcgaggattt ggtggcacca
     2221 accacggagg aggctacatg aatgctggcg ctggatatgg aagctatggg tacagcagca
     2281 attcggccac agcaggctac agtcagttct acagcaatgg agggcattct gggaatgccg
     2341 gtggtggagg cagcggggga ggtggtggct cgtccagcta cagctcctac taccaaggag
     2401 acagctacaa ctcaccagtg cccccgaaac atgctgggaa gaagccgctg catgggggcc
     2461 agcagaaacc ctcctacagc tcgggctacc agtcccacca gggccagcag caaccttaca
     2521 accagagcca gtacagcagc tacggcacgc cacaggacta cagtggtagt ggaggccgga
     2581 gtggagggaa cagctatggc tccagcgggt catcctacaa cacaggctca catgggggtt
     2641 atggcgcagg ttctggaggc agctcttcat accaaggcaa acaaggaggc tactcatcac
     2701 agtcaaacta cagctcccct gggtccagcc agagctacag cggccccgcc agctcctacc
     2761 agtcctcaca gggtggctac agtcggaaca cagaacacag catgaactac cagtacagat
     2821 aaaggcccag gctgcccctc tcaaccttct gcacctctgc ctccaacttg tctcgggaga
     2881 ttgagtctgc acatcaccag ttgccatgtc cactgggcca gtgcccaccc gtccacgttg
     2941 ctgacgttgc cacgctgtga ggcgtggtgg tccctgggac ccgtgctgtg accctattta
     3001 gctgtgtttt ggactcagtg tcttcagtgg tttgttagtt accattacac cttgtctgag
     3061 tagtgttccg agttcttgcc gtgcggaatc cctctgtctg tttatgcccg gtgtgagttc
     3121 catcgggtgt ctttaaatag ttgcagaagg gatacgtcat ctgttaatgc tttttgtgaa
     3181 gtgagttaaa tgagctttca ttattttaat gcttagtgtt tcagttttat aagtgaaaat
     3241 tttattttaa aaaacagtgg ggtttgtttt tttgtttttt tgtctttgtt tttgtttttt
     3301 tttttttttt tttttttttt tttggtatgt ctggatcatt caggcagtac atttgaattc
     3361 cgctgaatgt agataaataa aagaaaaaca aaacag
//
LOCUS       NM_001436435            3543 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 6, mRNA.
ACCESSION   NM_001436435 XM_063266239
VERSION     NM_001436435.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.406538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-281             JAXUCZ010000008.1  28219581-28219619
            282-511             JAXUCZ010000008.1  28220002-28220231
            512-689             JAXUCZ010000008.1  28220683-28220860
            690-837             JAXUCZ010000008.1  28223540-28223687
            838-929             JAXUCZ010000008.1  28224972-28225063
            930-1025            JAXUCZ010000008.1  28225440-28225535
            1026-1137           JAXUCZ010000008.1  28226074-28226185
            1138-1235           JAXUCZ010000008.1  28226611-28226708
            1236-1347           JAXUCZ010000008.1  28227262-28227373
            1348-1458           JAXUCZ010000008.1  28227460-28227570
            1459-1658           JAXUCZ010000008.1  28228703-28228902
            1659-1826           JAXUCZ010000008.1  28229217-28229384
            1827-1949           JAXUCZ010000008.1  28230383-28230505
            1950-2126           JAXUCZ010000008.1  28230664-28230840
            2127-2283           JAXUCZ010000008.1  28230937-28231093
            2284-2337           JAXUCZ010000008.1  28231210-28231263
            2338-2703           JAXUCZ010000008.1  28234392-28234757
            2704-2832           JAXUCZ010000008.1  28235346-28235474
            2833-3543           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3543
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2969
                     /gene="Ilf3"
                     /note="isoform 6 is encoded by transcript variant 6; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 6"
                     /protein_id="NP_001423364.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRRPMRIFVNDDRHVMAKHSSVYPTQEELEAV
                     QNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTL
                     RGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEIL
                     QSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLA
                     ALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTAN
                     RPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHA
                     LRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGE
                     EKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVE
                     VDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAP
                     PPVVEAVSNPSSVFPSDATTEGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKR
                     FVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGP
                     KFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAG
                     AGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVP
                     PKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYS
                     SYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGG
                     SSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     misc_feature    540..1304
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    540..1304
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1470..1688
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1470..1688
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1485..1487,1494..1499,1506..1511,1515..1517,
                     1557..1562,1566..1568,1572..1574,1623..1631,1638..1640)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1485..1487,1494..1499,1506..1511,1515..1517,
                     1557..1562,1566..1568,1572..1574,1623..1631,1638..1640)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1833..2048
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1833..2048
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1854..1856,1860..1865,1872..1874,1911..1913,
                     1920..1928,1938..1940,1986..1997)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1854..1856,1860..1865,1872..1874,1911..1913,
                     1920..1928,1938..1940,1986..1997)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            243..281
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..511
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..689
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            690..837
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..929
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1025
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1137
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1235
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1347
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1658
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1826
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1949
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2126
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2283
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2337
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2703
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2832
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3543
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tggcattgta tcatcatcac ttcatcacaa gaagaagaag gcgtcccatg agaatttttg
      301 tgaatgatga tcgccatgtg atggcaaagc attcttcagt atacccaaca caagaggagc
      361 tggaggctgt acagaacatg gtgtcccaca ctgagcgggc cctcaaggct gtctctgact
      421 ggattgatga gcaggagaaa ggcaacagcg agctctctga agcagaaaat atggacacac
      481 ccccagatga tgagagcaaa gaaggggctg gggaacagaa ggcggaacac atgactagga
      541 ccctgagggg cgtgatgcgg gtcggcctgg tagccaaggg tcttctgctc aagggggact
      601 tggatctgga gctggttctg ctctgtaagg agaagcccac aactgccctt ctggacaagg
      661 tggctgacaa cctggccatc cagcttacta ctgtaacaga agacaagtat gaaatactcc
      721 aatctgtgga tgatgctgcg attgtgataa aaaacacaaa agagcccccc ttgtccttga
      781 ccatccatct gacctcccct gttgtcagag aagaaatgga gaaagtatta gctggagaaa
      841 cgctatcagt caacgacccc ccggacgttc tggacaggca gaaatgcctt gctgccttgg
      901 cgtccctccg acacgccaag tggttccagg ctagagccaa tgggctgaag tcatgtgtca
      961 ttgtcatccg tgtcctaagg gacttgtgta cccgagtgcc cacctggggt cctctcagag
     1021 gatggcctct ggagctgctg tgtgagaagt ccatcggcac tgccaatagg ccaatgggtg
     1081 ctggtgaagc cctgcggaga gtactggagt gcctggcttc cggcatcgta atgccagatg
     1141 gttctggcat ttatgaccct tgtgaaaaag aagccactga tgctattggg catctagaca
     1201 gacagcaacg ggaagatatc acacagagtg cgcagcatgc tctgcggctt gctgcctttg
     1261 gccagctcca taaagtactg ggaatggacc cactgccttc caaaatgccc aagaaaccaa
     1321 agaacgagaa cccggtggac tatactgttc aaatcccccc cagcaccacc tacgccatca
     1381 cacccatgaa acgccctatg gaagaagatg gggaggagaa gtctcccagc aaaaagaaaa
     1441 agaagatcca gaagaaagag gagaaggctg agcctcccca agctatgaat gccctgatga
     1501 ggttaaacca gctgaagcca gggctacagt acaagctgat ctcccagacg ggtcctgttc
     1561 acgctcccat cttcaccatg tctgtggagg tagacggcag tacctttgag gcctcagggc
     1621 catctaaaaa gaccgccaag ctacatgtgg ctgtgaaggt gttacaggac atgggattgc
     1681 caacaggcgc tgaaggcaga gactccagca agggggagga ctctgctgag gagtcagatg
     1741 ggaagccagc agtagtggcc ccaccccctg tggtggaagc agtctccaac cccagttctg
     1801 tcttcccttc agatgccact actgaggggc cgattttgac taagcacggc aagaatcctg
     1861 taatggagct taatgagaag agacgtggcc tcaaatatga gctcatttct gagacagggg
     1921 gcagccacga caaacggttt gttatggagg ttgaggtgga cggacagaag tttcaaggtg
     1981 ctggctcaaa caaaaaggta gcaaaggctt atgctgcact tgccgcatta gagaagcttt
     2041 tccctgacgc ccctcttgct cttgaagcca acaagaagaa aagagcccct gtgcctgtcc
     2101 gaggcggacc caaatttgct gccaagccac ataaccctgg ctttggcatg ggaggcccca
     2161 tgcataatga agcgccccca cctcccaaca tccgaggtcg gggccgagga ggtaacatcc
     2221 gagggcgagg acgggggcga ggatttggtg gcaccaacca cggaggaggc tacatgaatg
     2281 ctggcgctgg atatggaagc tatgggtaca gcagcaattc ggccacagca ggctacagtc
     2341 agttctacag caatggaggg cattctggga atgccggtgg tggaggcagc gggggaggtg
     2401 gtggctcgtc cagctacagc tcctactacc aaggagacag ctacaactca ccagtgcccc
     2461 cgaaacatgc tgggaagaag ccgctgcatg ggggccagca gaaaccctcc tacagctcgg
     2521 gctaccagtc ccaccagggc cagcagcaac cttacaacca gagccagtac agcagctacg
     2581 gcacgccaca gggcaagcag aaaggctatg gccatgggca gggcagctac tcctcctact
     2641 ccaactctta caactcccct ggtggtggtg ggggctctga ctacagctac gacagcaaat
     2701 tcaactacag tggtagtgga ggccggagtg gagggaacag ctatggctcc agcgggtcat
     2761 cctacaacac aggctcacat gggggttatg gcgcaggttc tggaggcagc tcttcatacc
     2821 aaggcaaaca aggaggctac tcatcacagt caaactacag ctcccctggg tccagccaga
     2881 gctacagcgg ccccgccagc tcctaccagt cctcacaggg tggctacagt cggaacacag
     2941 aacacagcat gaactaccag tacagataaa ggcccaggct gcccctctca accttctgca
     3001 cctctgcctc caacttgtct cgggagattg agtctgcaca tcaccagttg ccatgtccac
     3061 tgggccagtg cccacccgtc cacgttgctg acgttgccac gctgtgaggc gtggtggtcc
     3121 ctgggacccg tgctgtgacc ctatttagct gtgttttgga ctcagtgtct tcagtggttt
     3181 gttagttacc attacacctt gtctgagtag tgttccgagt tcttgccgtg cggaatccct
     3241 ctgtctgttt atgcccggtg tgagttccat cgggtgtctt taaatagttg cagaagggat
     3301 acgtcatctg ttaatgcttt ttgtgaagtg agttaaatga gctttcatta ttttaatgct
     3361 tagtgtttca gttttataag tgaaaatttt attttaaaaa acagtggggt ttgttttttt
     3421 gtttttttgt ctttgttttt gttttttttt tttttttttt tttttttttt ggtatgtctg
     3481 gatcattcag gcagtacatt tgaattccgc tgaatgtaga taaataaaag aaaaacaaaa
     3541 cag
//
LOCUS       NM_053730               4279 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus STAG3 cohesin complex component (Stag3),
            transcript variant 1, mRNA.
ACCESSION   NM_053730
VERSION     NM_053730.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4279)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   2  (bases 1 to 4279)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 4279)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   4  (bases 1 to 4279)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
REFERENCE   5  (bases 1 to 4279)
  AUTHORS   Lee,J. and Hirano,T.
  TITLE     RAD21L, a novel cohesin subunit implicated in linking homologous
            chromosomes in mammalian meiosis
  JOURNAL   J Cell Biol 192 (2), 263-276 (2011)
   PUBMED   21242291
REFERENCE   6  (bases 1 to 4279)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   7  (bases 1 to 4279)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   8  (bases 1 to 4279)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   9  (bases 1 to 4279)
  AUTHORS   Bayes,M., Prieto,I., Noguchi,J., Barbero,J.L. and Perez Jurado,L.A.
  TITLE     Evaluation of the Stag3 gene and the synaptonemal complex in a rat
            model (as/as) for male infertility
  JOURNAL   Mol Reprod Dev 60 (3), 414-417 (2001)
   PUBMED   11599053
REFERENCE   10 (bases 1 to 4279)
  AUTHORS   Pezzi,N., Prieto,I., Kremer,L., Perez Jurado,L.A., Valero,C., Del
            Mazo,J., Martinez-A,C. and Barbero,J.L.
  TITLE     STAG3, a novel gene encoding a protein involved in meiotic
            chromosome pairing and location of STAG3-related genes flanking the
            Williams-Beuren syndrome deletion
  JOURNAL   FASEB J 14 (3), 581-592 (2000)
   PUBMED   10698974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_053730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000012.1  22398299-22398447
            150-323             JAXUCZ010000012.1  22399756-22399929
            324-420             JAXUCZ010000012.1  22401297-22401393
            421-540             JAXUCZ010000012.1  22401672-22401791
            541-637             JAXUCZ010000012.1  22407696-22407792
            638-714             JAXUCZ010000012.1  22408708-22408784
            715-919             JAXUCZ010000012.1  22409067-22409271
            920-1071            JAXUCZ010000012.1  22409670-22409821
            1072-1145           JAXUCZ010000012.1  22414638-22414711
            1146-1269           JAXUCZ010000012.1  22415504-22415627
            1270-1368           JAXUCZ010000012.1  22416126-22416224
            1369-1448           JAXUCZ010000012.1  22416419-22416498
            1449-1556           JAXUCZ010000012.1  22416862-22416969
            1557-1671           JAXUCZ010000012.1  22417168-22417282
            1672-1777           JAXUCZ010000012.1  22417405-22417510
            1778-1881           JAXUCZ010000012.1  22417734-22417837
            1882-1974           JAXUCZ010000012.1  22418090-22418182
            1975-2064           JAXUCZ010000012.1  22418294-22418383
            2065-2265           JAXUCZ010000012.1  22418601-22418801
            2266-2336           JAXUCZ010000012.1  22418902-22418972
            2337-2424           JAXUCZ010000012.1  22419070-22419157
            2425-2502           JAXUCZ010000012.1  22419732-22419809
            2503-2595           JAXUCZ010000012.1  22419887-22419979
            2596-2764           JAXUCZ010000012.1  22420097-22420265
            2765-2901           JAXUCZ010000012.1  22420375-22420511
            2902-3003           JAXUCZ010000012.1  22421314-22421415
            3004-3152           JAXUCZ010000012.1  22423117-22423265
            3153-3281           JAXUCZ010000012.1  22423448-22423576
            3282-3439           JAXUCZ010000012.1  22423659-22423816
            3440-3674           JAXUCZ010000012.1  22425680-22425914
            3675-3776           JAXUCZ010000012.1  22426079-22426180
            3777-3849           JAXUCZ010000012.1  22426433-22426505
            3850-3921           JAXUCZ010000012.1  22427913-22427984
            3922-4279           JAXUCZ010000012.1  22428198-22428555
FEATURES             Location/Qualifiers
     source          1..4279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..4279
                     /gene="Stag3"
                     /note="STAG3 cohesin complex component"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
     exon            1..149
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..323
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..3930
                     /gene="Stag3"
                     /note="cohesin subunit SA-3-like; SCC3 homolog 3;
                     stromalin-3; stromal antigen 3"
                     /codon_start=1
                     /product="cohesin subunit SA-3"
                     /protein_id="NP_446182.1"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
                     /translation="MPTLWSPSTQHHGSSSGSMSSPLRKSVRCAQMALSPCSSNIQPC
                     DDRDSQGTAEWDSSSTSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPGG
                     NDKNKSVPPTSDLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKS
                     TVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQ
                     YSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQ
                     RQYEAERNKGPEQRAPERLESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPE
                     IRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELS
                     SRMELFTNRFKDRMVSMVMDRESEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYI
                     SNRAMASSAGEFVYWKIFHPECGAKAVSGRERRRSPQAQRTFIYLLLAFFMESEHHDH
                     AAYLVDSLWDCAGSYLKDWESLTSLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPP
                     VGRITGKKSLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAENVAPLLRLLSYFD
                     LNIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFAR
                     SQLVDLLTDRFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCS
                     RLLRKAVDTGEVPHQVILPALTLVYFSILWTVTHISESTSQKQLMSLKKRMVAFCELC
                     QSCLSDVDPEIQEQAFVLLSDLLLIFSPQMVVGGRDFLRPLVFFPEATLQSELASFLM
                     DHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNK
                     FYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQDLTELPAFIEMR
                     DLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSREPPNIAFLELLSEFS
                     PRLFHQDKQLLLSYLEKCLQRVSMAPSHPWGPVTTYCHSLHLVENTAEASSQGPPHSK
                     KRCIEVPRRLQEEESSSQGESLQLNSGPTTPTLTSTAVKRRQSPRTVGKRQKGGPGPG
                     PGPGPGPGPGPGPGPGPGPGPELICSQQLSGTQRLKMSSAPCFQIRCDPSGSGLGKQM
                     TRLSLMEEDEEEELRLLDEEWQCGDKLLHSPSSPSEHGLDLLDTTELNMEDF"
     misc_feature    160..489
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    463..>1437
                     /gene="Stag3"
                     /note="Cohesin [Cell division and chromosome
                     partitioning]; Region: IRR1; COG5537"
                     /db_xref="CDD:227824"
     misc_feature    463..>1437
                     /gene="Stag3"
                     /note="Cohesin [Cell division and chromosome
                     partitioning]; Region: IRR1; COG5537"
                     /db_xref="CDD:227824"
     misc_feature    721..1062
                     /gene="Stag3"
                     /note="STAG domain; Region: STAG; pfam08514"
                     /db_xref="CDD:462502"
     misc_feature    721..1062
                     /gene="Stag3"
                     /note="STAG domain; Region: STAG; pfam08514"
                     /db_xref="CDD:462502"
     misc_feature    3445..3666
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3847..3927
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3859..3861
                     /gene="Stag3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O70576; propagated from
                     UniProtKB/Swiss-Prot (Q99M76.1); phosphorylation site"
     exon            324..420
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..540
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..637
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..714
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..919
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1071
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1145
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1269
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1368
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1448
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1556
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1671
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1777
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1881
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1974
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2064
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2265
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2336
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2424
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2502
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2595
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2764
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2901
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3003
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3152
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3281
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3439
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3674
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3776
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3849
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3921
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4279
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttacccgccc tccacctgag gaagaggagc cgctgcggcg ggcgtctcgc ttcagaggtg
       61 ggatgtccac agagatctga aaggacccct gaggtggtga tctttcttca actgtgttca
      121 tctagaggtc attcttccaa gctcaaacac tggattaaca tgcctactct gtggtcaccc
      181 tccacccagc accatggctc ttcctcaggc agtatgtcct cccctcttcg aaagtctgtg
      241 agatgtgcac agatggcctt gtctccttgt tcttccaaca tccaaccctg tgatgacaga
      301 gactcccagg gaactgcaga atgggatagt tcctcaacta gtgaagacag tgactttgaa
      361 gatagcttaa gaagaaatgt gaggaagaga gcagcaaaac gaccacccaa agctatccca
      421 gtggcaaaac atccgaagaa gcagtcccac atagtacctg gtgggaatga caagaacaag
      481 tcagtgccgc caaccagtga cctttttgat gctgtgaaag ctgctagaag ttgtgcgcag
      541 tctttggtag atgagtggct agaaaactac aagcaagatg aaaatgcagg attcttggaa
      601 cttgttaatt ttttcatccg agcctgtgga tgtaaaagca ctgtcacacc cgagatgttc
      661 aagacaatgt ccaactcaga gatcatccag cacctaacag aagagtttaa tgaggactca
      721 ggtgactatc ccctgacagc tccaggtcca tcctggaaga agttccaggg aagcttctgt
      781 gagtttgtga agacactagt ctgtcagtgc cagtacagcc tcctctttga cggctttcca
      841 atggatgacc ttatctccct gctcattggc ctctcagatt cccaggtccg agcctttcgt
      901 catactagta ctttggctgc catgaagcta atgacttctc tggtaaaagt tgcactccag
      961 ttgagtctgc acaaagacaa caatcaacgt cagtatgagg cagaacgaaa caaggggcca
     1021 gagcagaggg caccagagcg gctcgagagt ctgctggaga aacgaaaaga gttccaagag
     1081 aatcaagagg agatagaggg gatgatgaat gccatcttca ggggtgtctt tgttcatcgg
     1141 tacagggaca tccttcctga gatccgtgct gtctgcatcg aggagatcgg gtgttggatg
     1201 caaagctaca gcacctcctt tcttaatgac agctacctaa aatatattgg ctggaccctg
     1261 catgacaagc acaaggaagt ccgcctaaag tgtgtgaagg ctctggcagg gctgtacagc
     1321 aaccaggagc tgagttcacg gatggagctc tttactaatc gcttcaagga ccggatggtt
     1381 tccatggtca tggacagaga gagtgaagta gcagtggagg ccatcagatt gctgaccctt
     1441 attctgaaga acatggaggg agtactgact agtgcagatt gtgagaaaat ttactccatt
     1501 gtatacattt ctaatcgtgc catggcctct tctgcagggg aatttgtgta ctggaagatt
     1561 ttccatcctg aatgtggggc aaaagcagtg agtggcaggg agcgacgccg gagtccacaa
     1621 gcccagagga ctttcattta ccttttattg gccttcttta tggagagtga gcatcacgac
     1681 catgctgctt acctagttga cagcttgtgg gactgtgcag ggtcttacct gaaggactgg
     1741 gagagtctga caagtctgtt gctgcagaaa gaccagaatc tgggtgatat gcaagagaga
     1801 atgttgatag aaatcctggt gtccagtgcc cggcaagctg cagagggtca cccaccagtg
     1861 gggcgcatca ctggaaagaa gagtctgacc gccaaagaac gcaagcttca agcttatgat
     1921 aaggtgaagc tggctgagca cctcatcccc ctcttgcccc agctccttgc caagttctca
     1981 gcagatgcag agaacgttgc tcccttgctc cggctgctca gttactttga cctcaacatt
     2041 tattgcactc agcgcttgga gaagcacttg gagctgcttc tgcaacaact ccaggaggtg
     2101 gtggtgaagc acgtagagcc tgaggtgctt gaggctgcag cacatgccct ctatttgctc
     2161 tgcaagccag agttcacctt cttcagcaga gtggacttcg ccagaagcca attagtagat
     2221 ctgctgactg atagattcca gcaggagctt gacgacctaa tgcagtcatc cttcctagat
     2281 gaggatgagg tatacagtct gacagccact ctgaagcgtc tctctgcctt ttacaatgct
     2341 catgacctga ctcgctggga gatctctgaa ccatgttctc gactcctccg gaaggctgta
     2401 gacacaggag aagttcctca ccaggtgatt ttgccagcct tgactctggt atatttttcc
     2461 attctctgga cagtgaccca catttcagag tctacttccc aaaagcagct gatgagtctg
     2521 aagaaaagaa tggtagcctt ctgtgaactt tgccaaagct gcctctcaga cgtggaccca
     2581 gagatccagg agcaggcttt tgttttatta agtgacctgc ttctcatctt cagcccccag
     2641 atggttgtag ggggccggga tttccttagg cctcttgtct tttttccgga agctactctc
     2701 cagtcggaac tagccagctt cctcatggac catgtctttc tccagcctgg agaattgggc
     2761 aacggtcaat cacaggagga tcacgtccaa atagagcttc tgcaccagag gcgccgcctg
     2821 cttgcaggat tttgtaagct gttgctttat ggggtattgg aactggatgc ggcctcagat
     2881 gttttcaaac actacaacaa gttctatgaa gattatggtg acattatcaa ggaaacatta
     2941 actcgggcga gacaaattga ccgatgtcag tgctctcgga tcctgctcct gagcctaaag
     3001 cagctctaca cagaactgat acaggagcag gggccccagg acctgacaga actgccagcc
     3061 ttcattgaga tgagagacct ggcccggagg tttgccttga gctttggacc ccagcagctc
     3121 cataacagag atcttgtggt catgctgcac aaggaaggca tcaagttctc attgtctgag
     3181 cttcctcctg ctggctcttc tcgagagccc ccaaatattg cattcctgga gcttctttca
     3241 gagttctccc cccgcctctt ccatcaggac aaacagctac tactatcata cctggaaaag
     3301 tgtctgcagc gtgtctccat ggcacctagc catccctggg gtccagtcac cacctactgc
     3361 cactccctcc atctagtaga gaacacagca gaggccagct ctcaggggcc cccccactcc
     3421 aagaagaggt gtattgaagt tccccgcagg cttcaggaag aagagtcttc atcccaggga
     3481 gaaagccttc agctgaacag tggccccaca acacctacac tcacctccac agcagtgaag
     3541 agaaggcagt ctccgaggac agtaggcaag aggcaaaaag gtggaccagg accaggacca
     3601 ggaccaggac caggaccagg accaggacca ggaccaggac caggaccagg accaggacca
     3661 gagctgatct gcagtcagca gctctcaggc acccagaggt tgaaaatgtc gagtgcaccg
     3721 tgtttccaga ttcgatgtga tccttctggc tctggcttgg gcaagcagat gacccgactc
     3781 agccttatgg aagaagatga ggaagaagag ctgagacttc tggatgaaga atggcaatgt
     3841 ggagacaagc tacttcatag cccttcttct cccagtgagc atgggctgga cctattagat
     3901 acaacagagc tgaacatgga ggatttctga tgggacttag gcttctcccc ttctccactt
     3961 accacactgc aaggccatga gtgagcaaac gaaggagtaa aatgaagcat tctttgggtc
     4021 ccagccaagt actttaaggg aatagagaaa tggccttatt caaacctcca tttctttctg
     4081 aagtgggtgc tgtatataga tgctatgagc cctgtgatcc ttaattcacc ctagctttat
     4141 gcttttgcct gtttgaagtg gtgggagttg ggtagggagc tttacctcag tattgaagtt
     4201 taataaacct tctgtttgat atctcttccc caaacactgc caagctctca ataaacatgt
     4261 tcacatcagc tatttcata
//
LOCUS       NM_138913               1421 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase 1A (Oas1a),
            transcript variant 2, mRNA.
ACCESSION   NM_138913
VERSION     NM_138913.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Leisching,G., Cole,V., Ali,A.T. and Baker,B.
  TITLE     OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and
            enhance cytokine secretion
  JOURNAL   Int J Infect Dis 80S, S77-S84 (2019)
   PUBMED   30822544
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Sarmiento,L., Frisk,G., Anagandula,M., Hodik,M., Barchetta,I.,
            Netanyah,E., Cabrera-Rode,E. and Cilio,C.M.
  TITLE     Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells
            and Induces Pro-Inflammatory Innate Immune Response
  JOURNAL   Viruses 9 (2), 25 (2017)
   PUBMED   28146100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Kim,S., Kim,M.J., Park,D.Y., Chung,H.J., Kim,C.H., Yoon,J.H. and
            Kim,H.J.
  TITLE     Mitochondrial reactive oxygen species modulate innate immune
            response to influenza A virus in human nasal epithelium
  JOURNAL   Antiviral Res 119, 78-83 (2015)
   PUBMED   25930096
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Go,M.J., Hwang,J.Y., Kim,Y.J., Hee Oh,J., Kim,Y.J., Heon Kwak,S.,
            Soo Park,K., Lee,J., Kim,B.J., Han,B.G., Cho,M.C., Cho,Y.S. and
            Lee,J.Y.
  TITLE     New susceptibility loci in MYL2, C12orf51 and OAS1 associated with
            1-h plasma glucose as predisposing risk factors for type 2 diabetes
            in the Korean population
  JOURNAL   J Hum Genet 58 (6), 362-365 (2013)
   PUBMED   23575436
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Donovan,J., Dufner,M. and Korennykh,A.
  TITLE     Structural basis for cytosolic double-stranded RNA surveillance by
            human oligoadenylate synthetase 1
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), 1652-1657 (2013)
   PUBMED   23319625
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Hartmann,R., Walko,G. and Justesen,J.
  TITLE     Inhibition of 2'-5' oligoadenylate synthetase by divalent metal
            ions
  JOURNAL   FEBS Lett 507 (1), 54-58 (2001)
   PUBMED   11682059
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Truve,E., Aaspollu,A., Honkanen,J., Puska,R., Mehto,M., Hassi,A.,
            Teeri,T.H., Kelve,M., Seppanen,P. and Saarma,M.
  TITLE     Transgenic potato plants expressing mammalian 2'-5' oligoadenylate
            synthetase are protected from potato virus X infection under field
            conditions
  JOURNAL   Biotechnology (N Y) 11 (9), 1048-1052 (1993)
   PUBMED   7764002
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Shiojiri,S., Fukunaga,R., Ichii,Y. and Sokawa,Y.
  TITLE     Structure and expression of a cloned cDNA for human
            (2'-5')oligoadenylate synthetase
  JOURNAL   J Biochem 99 (5), 1455-1464 (1986)
   PUBMED   3754863
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Wathelet,M., Moutschen,S., Cravador,A., DeWit,L., Defilippi,P.,
            Huez,G. and Content,J.
  TITLE     Full-length sequence and expression of the 42 kDa 2-5A synthetase
            induced by human interferon
  JOURNAL   FEBS Lett 196 (1), 113-120 (1986)
   PUBMED   3753689
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Shimizu,N. and Sokawa,Y.
  TITLE     (2'-5')Oligoadenylate synthetase in pig spleen: isolation and
            characterization
  JOURNAL   J Biochem 94 (5), 1421-1428 (1983)
   PUBMED   6654863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_138913.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z18877.1, SRR26643429.43390.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000012.1  41330445-41330695
            252-540             JAXUCZ010000012.1  41332063-41332351
            541-725             JAXUCZ010000012.1  41334998-41335182
            726-958             JAXUCZ010000012.1  41338519-41338751
            959-1112            JAXUCZ010000012.1  41339378-41339531
            1113-1421           JAXUCZ010000012.1  41340818-41341126
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1421
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5' oligoadenylate synthetase 1A"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
     exon            1..251
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1145
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /EC_number="2.7.7.84"
                     /note="isoform 2 is encoded by transcript variant 2;
                     2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate
                     synthase 1; 2'-5' oligoadenylate synthetase 1G; 2-5A
                     synthetase 1; (2-5')oligo(A) synthetase 1; 2-5A synthase
                     1; (2-5')oligo(A) synthase 1; 2',5'-oligoadenylate
                     synthetase 1, 40/46kDa; 25 oligoadenylate synthetase; 2-5A
                     synthase 1A; (2-5')oligo(A) synthase 1A;
                     2'-5'-oligoadenylate synthase 1A"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 1A isoform 2"
                     /protein_id="NP_620268.2"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
                     /translation="MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKE
                     RCFRDTVHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKE
                     IKKQLYEVQREKHFRVKFEVQSSWWPNPRALSFKLSAPHLQQEVEFDVLPAYDVLGHV
                     SLYSNPDPKIYTILISECISLGKEGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQ
                     LCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQGFRTILELVTKYQQLRIYWTK
                     YYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRRLASEARLWLQYPCF
                     MNRGGSPVSSWEVPVDEAWSCILL"
     misc_feature    108..251
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05961.1);
                     Region: Interaction with dsRNA.
                     /evidence=ECO:0000250|UniProtKB:P00973"
     misc_feature    147..569
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    147..569
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    order(252..260,267..269,273..281,294..296,300..302,
                     450..455,462..464,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(252..260,267..269,273..281,294..296,300..302,
                     450..455,462..464,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(294..296,300..302,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    order(294..296,300..302,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    558..1115
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    558..1115
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    669..701
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05961.1);
                     Region: Interaction with dsRNA.
                     /evidence=ECO:0000250|UniProtKB:P00973"
     exon            252..540
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            541..725
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            726..958
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1112
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1421
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttccaagt tcaaccaggc tgcgagacac aggacctgca ggctgcagag gcaaaagctc
       61 cggaggtcat ggagcaggaa ctcaggagca ccccgtcctg gaagctggac aagttcatag
      121 aggtttacct ccttccaaac accagcttcc gtgatgatgt caaatcagct atcaatgtcc
      181 tgtgtgattt cctgaaggag agatgcttcc gagatactgt ccacccagtg agggtctcca
      241 aggtggtgaa gggcggctcc tcaggcaaag gcaccacact caagggcaag tcagacgctg
      301 acctggtggt gttccttaac aatttcacca gctttgagga tcagttaaac agacggggag
      361 agttcatcaa ggaaattaag aaacagctgt atgaggttca gcgtgaaaaa cattttagag
      421 tgaagtttga ggtccagagt tcatggtggc ccaacccccg ggctctgagc ttcaagctga
      481 gtgcaccaca cctccaacag gaggtggagt ttgatgtgct tccagcctat gatgtcctag
      541 gtcatgttag cctctacagc aatcctgatc ccaagatcta caccatcctc atctccgaat
      601 gtatctccct ggggaaggag ggcgagttct ctacctgctt cacggagctc cagaggaact
      661 tcctgaagca gcgcccaacc aagcttaaga gtctcatccg cctggtcaag cactggtacc
      721 aactgtgtaa ggagaagctg gggaagccgc tgcccccaca gtacgccctg gagctgctca
      781 cggtctatgc ctgggaacgt ggaaatggaa ttactgagtt caacacagct cagggcttcc
      841 ggacaatctt ggaactggtc acaaagtacc agcagcttcg aatctactgg acaaagtatt
      901 atgactttca acacccagat gtctccaaat acctacacag acagctcaga aaatccaggc
      961 ctgtgatcct ggaccctgct gacccaacag ggaacgtggc tggtgggaac caagaaggct
     1021 ggcggcggtt ggcctcagag gcgaggctgt ggctgcagta cccatgtttt atgaacaggg
     1081 gtggttcccc agtgagctcc tgggaagtgc cggtggatga ggcctggtca tgcatcctgc
     1141 tgtgaaccca gcagcaccag cccaggaggc tccggagtca ggggcacgtg ctgctctgct
     1201 gcaggacctt gacacagtga gggagggccc cactcgggat cacagtccat gcttctgatg
     1261 cccgcccgcc atgtttgaat actgtccaat cacagacagc cttcctcaac agattcagaa
     1321 ggggcggaaa gaactcaagc ttgacttcca tctgaccgtc cacctgttgg gaggttctgt
     1381 ccaaccatgt ctgtcaacaa caataaagta cagcaggtgc c
//
LOCUS       NM_031126               2812 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus syntaxin binding protein 2 (Stxbp2), transcript
            variant 1, mRNA.
ACCESSION   NM_031126
VERSION     NM_031126.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Wan,L., Chen,X. and Almers,W.
  TITLE     Munc18-dependent and -independent clustering of syntaxin in the
            plasma membrane of cultured endocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (49) (2021)
   PUBMED   34857632
  REMARK    GeneRIF: Munc18-dependent and -independent clustering of syntaxin
            in the plasma membrane of cultured endocrine cells.
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Yu,H., Shen,C., Liu,Y., Menasche,B.L., Ouyang,Y., Stowell,M.H.B.
            and Shen,J.
  TITLE     SNARE zippering requires activation by SNARE-like peptides in
            Sec1/Munc18 proteins
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8421-E8429 (2018)
   PUBMED   30127032
  REMARK    GeneRIF: SNARE zippering requires activation by SNARE-like peptides
            in Sec1/Munc18 proteins
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Qin,T., Liang,T., Zhu,D., Kang,Y., Xie,L., Dolai,S., Sugita,S.,
            Takahashi,N., Ostenson,C.G., Banks,K. and Gaisano,H.Y.
  TITLE     Munc18b Increases Insulin Granule Fusion, Restoring Deficient
            Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat
            Islets with Improvement in Glucose Homeostasis
  JOURNAL   EBioMedicine 16, 262-274 (2017)
   PUBMED   28163042
  REMARK    GeneRIF: Data show that Munc18b overexpression increased fusion of
            not only newcomer secretory granule (SG), but also predocked SGs in
            type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets.
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Gandasi,N.R. and Barg,S.
  TITLE     Contact-induced clustering of syntaxin and munc18 docks secretory
            granules at the exocytosis site
  JOURNAL   Nat Commun 5, 3914 (2014)
   PUBMED   24835618
  REMARK    GeneRIF: Secretory vesicles dock by inducing syntaxin1/munc18
            clustering in the target membrane.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Brochetta,C., Suzuki,R., Vita,F., Soranzo,M.R., Claver,J.,
            Madjene,L.C., Attout,T., Vitte,J., Varin-Blank,N., Zabucchi,G.,
            Rivera,J. and Blank,U.
  TITLE     Munc18-2 and syntaxin 3 control distinct essential steps in mast
            cell degranulation
  JOURNAL   J Immunol 192 (1), 41-51 (2014)
   PUBMED   24323579
  REMARK    GeneRIF: Munc18-2 and STX3 perform distinct, but complementary,
            functions to support, respectively, SG translocation and membrane
            fusion in mast cells.
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Coppola,T., Frantz,C., Perret-Menoud,V., Gattesco,S., Hirling,H.
            and Regazzi,R.
  TITLE     Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and
            controls exocytosis
  JOURNAL   Mol Biol Cell 13 (6), 1906-1915 (2002)
   PUBMED   12058058
  REMARK    GeneRIF: binds to granuphilin and controls exocytosis of pancreatic
            beta cells
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Lehtonen,S., Riento,K., Olkkonen,V.M. and Lehtonen,E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_031126.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U20283.1, SRR26643293.83416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000012.1  6487319-6487368
            51-100              JAXUCZ010000012.1  6488356-6488405
            101-182             JAXUCZ010000012.1  6488636-6488717
            183-259             JAXUCZ010000012.1  6489296-6489372
            260-338             JAXUCZ010000012.1  6490140-6490218
            339-442             JAXUCZ010000012.1  6490315-6490418
            443-591             JAXUCZ010000012.1  6490792-6490940
            592-676             JAXUCZ010000012.1  6491530-6491614
            677-807             JAXUCZ010000012.1  6491691-6491821
            808-915             JAXUCZ010000012.1  6491903-6492010
            916-973             JAXUCZ010000012.1  6492262-6492319
            974-1039            JAXUCZ010000012.1  6492427-6492492
            1040-1120           JAXUCZ010000012.1  6492573-6492653
            1121-1259           JAXUCZ010000012.1  6493124-6493262
            1260-1369           JAXUCZ010000012.1  6495264-6495373
            1370-1465           JAXUCZ010000012.1  6496468-6496563
            1466-1551           JAXUCZ010000012.1  6497074-6497159
            1552-1712           JAXUCZ010000012.1  6497234-6497394
            1713-2812           JAXUCZ010000012.1  6497939-6499038
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2812
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="syntaxin binding protein 2"
                     /db_xref="GeneID:81804"
                     /db_xref="RGD:619967"
     exon            1..50
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="upstream in-frame stop codon"
     CDS             14..1798
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /function="syntaxin binding protein"
                     /note="isoform 1 is encoded by transcript variant 1;
                     unc-18B; unc18-2; unc-18 homolog 2; unc-18 homolog B;
                     munc18-2; protein unc-18 homolog 2; protein unc-18 homolog
                     B; syntaxin binding protein Munc18-2"
                     /codon_start=1
                     /product="syntaxin-binding protein 2 isoform 1"
                     /protein_id="NP_112388.2"
                     /db_xref="GeneID:81804"
                     /db_xref="RGD:619967"
                     /translation="MAPLGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSC
                     CKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAA
                     HIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPF
                     RAGERGRQLDVLAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPS
                     LGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLHIEQDTYRYETTGLSESRE
                     KAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMP
                     QYQKELNKYSTHLHLADDCMKHFKGSVEKLCGVEQDLAMGSDAEGEKIKDTMKLIVPV
                     LLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSNLIRNLEQLGGTVTN
                     SAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVSSS
                     QAAVSSARFGHWHKNKAGIEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLI
                     GSSHILTPTRFLDDLRTLDQKLEDIALP"
     misc_feature    98..1753
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="Sec1 family; Region: Sec1; pfam00995"
                     /db_xref="CDD:460020"
     misc_feature    98..1753
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="Sec1 family; Region: Sec1; pfam00995"
                     /db_xref="CDD:460020"
     exon            51..100
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            101..182
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            183..259
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            260..338
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            339..442
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            443..591
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            592..676
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            677..807
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            808..915
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            916..973
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1039
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1120
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1259
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1369
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1465
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1551
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1712
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..2812
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttagggg aagatggcgc ccttggggct gaaggcggtg gtgggggaaa aaattctaag
       61 tggagtcatc cggagcgtta agaaggatgg cgagtggaag gtactcatca tggatcatcc
      121 gagcatgcga atcttgtcat cctgttgtaa aatgtcagat atcttggcgg agggcatcac
      181 cattgtggaa gacatcaaca aacggagaga acccattccc agcttggagg caatttattt
      241 gctgagtccc acagagaagt cggttcaggc tctgattgcg gacttccagg ggacaccaac
      301 cttcacctac aaagcagccc atatcttctt cacggacacg tgccccgagc ccttgttcag
      361 tgaactgggc cgctctcgcc tggcgaaggt ggtgaagaca ctgaaagaga tccacctcgc
      421 cttcctcccc tatgaggccc aggtgttctc tctggatgcc ccgcacagca cctataacct
      481 ttattgccca tttcgggcag gggagcgggg gcggcagctc gatgtgctgg cccagcagat
      541 agccacactg tgtgccactc ttcaggaata cccatccatt cgctaccgca agggcccaga
      601 agacacagcc cagctggccc atgctgtcct ggccaagctg aacgccttca aggcagacac
      661 tcccagtctg ggcgagggcc cagagaaaac acgctcacag ttgctcataa tggaccgggc
      721 agcagacccc gtgtccccgc tattacatga actcacattc caagccatgg cctatgatct
      781 tctgcacatc gagcaggaca catacaggta tgagaccaca ggactgagcg agtcccggga
      841 gaaggctgtg ctcctggatg aagacgatga cctgtgggtg gaactccggc acatgcacat
      901 agcggatgtg tccaagaagg tcacggagct cctgaagaca ttctgtgaga gcaagcggct
      961 gaccacagac aaggccaaca tcaaagacct gtcccacatc ctgaaaaaga tgccacagta
     1021 tcagaaggag ttgaacaagt actccacgca cctgcacttg gcagatgact gcatgaagca
     1081 cttcaagggc tcggtggaga agctgtgcgg tgtggagcag gacctggcca tgggctctga
     1141 tgcagagggt gagaagatca aggacaccat gaaactgatt gtcccggtgc tgttggatgc
     1201 ctccgtgcca ccctatgaca agatccgggt tctgctgctc tacatccttc tgcggaacgg
     1261 tgtgagtgag gaaaatctgg ccaagctgat ccagcatgct aatgtgcagt cctacagcaa
     1321 cctcatccgg aacctggagc agctgggggg cactgtcacc aactctgcgg gctcagggac
     1381 ctctagccgg ctggagcgga gagaacgcat ggagcccacc taccagctgt ctcgctggtc
     1441 cccagtcatc aaggacgtga tggaggatgt ggtggaggac cggctagacc gaaagctgtg
     1501 gcccttcgtg tctgaccctg cccctgtgtc tagctcccaa gcagctgtca gcagtgctcg
     1561 ctttggccac tggcataaaa acaaagctgg tatagaggct cgggctggac ccaggctcat
     1621 cgtgtacatt gtgggtggtg tcgccatgtc tgaaatgagg gctgcttatg aggtgaccag
     1681 ggccactgaa ggcaagtggg aggtacttat aggctcttcc cacatcctca ctccaacccg
     1741 cttcctcgat gacctcagga ccctggatca gaagctggag gacatagccc tgccctgact
     1801 cagctgcttg ctctgccctc tcctcctgtt ccagagaaat aaactcttcc cttcatcttt
     1861 ccatcagggc tcacctcact ttcttcccag agagagctgt ataaaccaga cccatgctgc
     1921 cggcctcccc ttatgttact gttctgcctg aaccttccct tggcccccag aagcagcttt
     1981 agcttccatg aacgttggga acctgggctc tggctctctg gctgggtccc tccatccaaa
     2041 ccctgatctt agcagacaaa ctgcagagga gacagagagc tgccaatcag ggaatggcag
     2101 ggctgcaacc ccattgtcac tagaattctt taggctgttt ggttagaatt atagaaaaaa
     2161 ccttaacctt tctctttatt ttgtgttaca cttgtgtgtc tgtctgtgca tcacatgcat
     2221 cagtgcctgt agaggtcaga atagggtgcg ggatccccgg gaccaggtat agatggttgt
     2281 gagaagccag gagatgcttg ggtctgctgc aagaacagcc agtcccttga ccactgaggc
     2341 atctccagct ctagaaatag aagcaggtag agtaggcccg gatcctgact cttcccctgg
     2401 atcctcccag gaactactgc aagtggaact tgaagcccca attctgggaa tcagagccag
     2461 catttaaagc acagcaaact caaacaccgg tttcctagtg gcccccaccc tcctccagcc
     2521 ttaggatatg cctgtaggtt ctgattgcag gatttaccag agtttttaat ggagaactta
     2581 taaactattc ctgggcctgg atggctcaga ggttaagagt gtttgctgct cttccagagg
     2641 cctggatttg gttcccaaca ctcacattgc gtggctcaaa gctgcttgta actccagctc
     2701 caggggattt ggtgctctct cccggtttca gtgggagccg agatacatgt gtgccctgcc
     2761 cccacacacc aataaacaaa taaacagaca ataaataaaa gcactccact ca
//
LOCUS       NM_001436444            1976 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 4, mRNA.
ACCESSION   NM_001436444 XM_063264786
VERSION     NM_001436444.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063264786.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.654941.1,
                                           SRR26360172.2477151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  117870535-117870689
            156-230             JAXUCZ010000008.1  117880565-117880639
            231-314             JAXUCZ010000008.1  117881890-117881973
            315-472             JAXUCZ010000008.1  117894634-117894791
            473-593             JAXUCZ010000008.1  117897631-117897751
            594-724             JAXUCZ010000008.1  117901968-117902098
            725-1976            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1976
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..155
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..230
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    227..229
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            231..314
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..472
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..898
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423373.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     317..886
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    329..853
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    329..853
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(329..331,416..418,425..430,437..439,443..445,
                     449..451,476..478,488..493,497..505,512..514,518..520,
                     530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(329..331,416..418,425..430,437..439,443..445,
                     449..451,476..478,488..493,497..505,512..514,518..520,
                     530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    350..373
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    350..373
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(359..376,416..421,425..427,491..496,668..670,
                     674..676,797..802)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(359..376,416..421,425..427,491..496,668..670,
                     674..676,797..802)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(383..385,389..403,440..445,449..457,470..478,
                     803..808,818..823,830..832)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(383..385,389..403,440..445,449..457,470..478,
                     803..808,818..823,830..832)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(416..418,422..424,428..433,503..514,521..523,
                     530..532,596..598)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(416..418,422..424,428..433,503..514,521..523,
                     530..532,596..598)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(425..430,497..499,512..514,518..523,527..532,
                     539..541,629..634,638..640)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(425..430,497..499,512..514,518..523,527..532,
                     539..541,629..634,638..640)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    425..427
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    425..427
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(431..433,509..523,530..532,605..607,617..619,
                     629..631)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(431..433,509..523,530..532,605..607,617..619,
                     629..631)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(431..436,509..514,518..523,530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(431..436,509..514,518..523,530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    491..502
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    491..502
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    497..550
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    500..553
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    500..553
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    665..676
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    665..676
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    794..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    794..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    878..880
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    884..886
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            473..593
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..724
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1976
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgcgctc cccgcccgcc gcccgcggtc ctccgtcggt tctctcctta gcccgccgtc
       61 tcccacggag ctgctcgccc ttgtctcgga gctcgcggac tcgcggacag gcgtcctcag
      121 cgcgaagagg ccggattcgg agtcgtcgtc ttgagccttg catctaagaa gtcccaggta
      181 ctttgtacaa ctgcatccca gaagctgagt ttcttcagca ccttcataag ggtttcactg
      241 tgtagccttg gttgttctgg aactcactgt agaccagact gtccgcctct acctcctgag
      301 tgctgggatt aaagtgatgg ctgccatcag gaagaaactg gtgattgttg gtgatggagc
      361 ttgtggtaag acatgcttgc tcatagtctt cagcaaggac cagttcccag aggtttatgt
      421 gcccacggtg tttgaaaact atgtggcaga tattgaagtg gacgggaagc aggtagagtt
      481 ggctttatgg gacacagctg gacaggaaga ttatgaccgt ctgaggcctc tctcctaccc
      541 agacactgat gttatactga tgtgtttttc catcgacagc cctgatagtt tagaaaacat
      601 cccagaaaaa tggactccag aagtcaagca tttctgtcca aatgtgccca tcatcctagt
      661 tgggaacaag aaggatcttc ggaatgatga gcacacaagg cgggagttag ccaaaatgaa
      721 gcaggagccg gtaaaacctg aagaaggcag agatatggca aacaggattg gcgcttttgg
      781 gtacatggag tgttcagcaa agaccaaaga cggagtgaga gaggtttttg agatggccac
      841 gagagctgct ctgcaagcta gacgcgggaa gaaaaagtcg gggtgcctca tcttgtgaag
      901 ccttgtgacg cgcagcctca tgcggttaat ttgaagtgct gtttattaat cttagtgtat
      961 gattactggc cttttcattt atctataatt tacctaagat tacaaatcag aagtcatctt
     1021 gctaccagta tttagaagcc aaccatgatt attaatgatg tccagcctgt ctgaccagcc
     1081 agggtccttc tgacactgct ctaacgccct ctctgcactc cacctgacac caggcgctca
     1141 ttcaaagaat ttcttaactt cctgcttctt tctagaaaga gaaacagttg gtaacttttg
     1201 tgaattaggc tgtaactact ttataactaa catgtcctgc ctattttctg tcagctgcga
     1261 ggaactctgg tgagtcacta cttcagagct ttactcctta acagattcca ttggcagagc
     1321 tctggggtgg gcacccagtg tttggaaact tgatcagcca gaaaggccca agtccacgca
     1381 gctgtggcag agttacagtt ctgtggtctc atgttagtta ccttatagtt actgtgtaat
     1441 tagtgccact taatgtatgt taccaaaaat aaatatatct accccagact agatgtagta
     1501 ttttttgtat aattggattt cctaattctg atatttgtca ttcccacaga aagtgtattg
     1561 cttttttttt tttttaagaa agtatttgga aataaagtca gatggaaaat tcatttttaa
     1621 aattcccatt ttgtcacttt ctctgataaa atatggccat atctccccta tttagcccta
     1681 tatatcattc cagtgcccct ttccagactg gactgaggaa ataggaattg gtttcatgcc
     1741 tgaggctgtt agactttgga ggtggcatag cctttctcac ctggactgca gggcctggct
     1801 ctaagtcaca gtgctccttt ctccacactg ttatccaagt cgcctcccag aggagccacc
     1861 agttcttatg ggtggcaatg ggtgggtggg tggggggtct cctctctcca gctgactaaa
     1921 cttttttctg taccagttaa tttttccaac taatagaata aaggcagttt tctaaa
//
LOCUS       NM_001436442            2324 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 2, mRNA.
ACCESSION   NM_001436442 XM_063264788
VERSION     NM_001436442.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 2324)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 2324)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 2324)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 2324)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063264788.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2121260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  117870535-117870689
            156-230             JAXUCZ010000008.1  117880565-117880639
            231-662             JAXUCZ010000008.1  117891707-117892138
            663-820             JAXUCZ010000008.1  117894634-117894791
            821-941             JAXUCZ010000008.1  117897631-117897751
            942-1072            JAXUCZ010000008.1  117901968-117902098
            1073-2324           JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2324
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..155
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..230
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..662
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    638..640
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            663..820
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             665..1246
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423371.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     665..1234
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    677..1201
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    677..1201
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(677..679,764..766,773..778,785..787,791..793,
                     797..799,824..826,836..841,845..853,860..862,866..868,
                     878..880)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(677..679,764..766,773..778,785..787,791..793,
                     797..799,824..826,836..841,845..853,860..862,866..868,
                     878..880)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    698..721
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    698..721
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(707..724,764..769,773..775,839..844,1016..1018,
                     1022..1024,1145..1150)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(707..724,764..769,773..775,839..844,1016..1018,
                     1022..1024,1145..1150)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(731..733,737..751,788..793,797..805,818..826,
                     1151..1156,1166..1171,1178..1180)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(731..733,737..751,788..793,797..805,818..826,
                     1151..1156,1166..1171,1178..1180)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(764..766,770..772,776..781,851..862,869..871,
                     878..880,944..946)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(764..766,770..772,776..781,851..862,869..871,
                     878..880,944..946)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    764..790
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    764..790
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    764..790
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(773..778,845..847,860..862,866..871,875..880,
                     887..889,977..982,986..988)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(773..778,845..847,860..862,866..871,875..880,
                     887..889,977..982,986..988)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    773..775
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    773..775
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(779..781,857..871,878..880,953..955,965..967,
                     977..979)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(779..781,857..871,878..880,953..955,965..967,
                     977..979)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(779..784,857..862,866..871,878..880)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(779..784,857..862,866..871,878..880)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    839..850
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    839..850
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    845..898
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    848..901
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    848..901
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    1013..1024
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    1013..1024
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    1142..1150
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    1142..1150
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    1226..1228
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            821..941
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1072
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..2324
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgcgctc cccgcccgcc gcccgcggtc ctccgtcggt tctctcctta gcccgccgtc
       61 tcccacggag ctgctcgccc ttgtctcgga gctcgcggac tcgcggacag gcgtcctcag
      121 cgcgaagagg ccggattcgg agtcgtcgtc ttgagccttg catctaagaa gtcccaggta
      181 ctttgtacaa ctgcatccca gaagctgagt ttcttcagca ccttcataag atttattcat
      241 ttattatata taagtccact gcagctgtct tcagacacca gaagaaggtt tcggatccca
      301 ttacaaatgg ttgtgagcca ccatgtggtt gctgggaatt gaactcatga cctctggagg
      361 agcagtcggg tgctcttaac cgctgagcca tctctccagc cccatcttta tcccatctta
      421 actgctgagc cacctctcca tccctgctcc cacctaaaat ttatttaatt aatttatctt
      481 atatgtaagt atttggcttt cgtgtatgta tgtgcaccac ctgtgtgtct ggtgtcctca
      541 tcagatccct ggaattggag ttgcagatgg ttgtgagcca tcatgtgggt gctgagaact
      601 gaacccttcc tctgcaagaa caagtgctct taaccactga gccatctctg gctccctcag
      661 agtgatggct gccatcagga agaaactggt gattgttggt gatggagctt gtggtaagac
      721 atgcttgctc atagtcttca gcaaggacca gttcccagag gtttatgtgc ccacggtgtt
      781 tgaaaactat gtggcagata ttgaagtgga cgggaagcag gtagagttgg ctttatggga
      841 cacagctgga caggaagatt atgaccgtct gaggcctctc tcctacccag acactgatgt
      901 tatactgatg tgtttttcca tcgacagccc tgatagttta gaaaacatcc cagaaaaatg
      961 gactccagaa gtcaagcatt tctgtccaaa tgtgcccatc atcctagttg ggaacaagaa
     1021 ggatcttcgg aatgatgagc acacaaggcg ggagttagcc aaaatgaagc aggagccggt
     1081 aaaacctgaa gaaggcagag atatggcaaa caggattggc gcttttgggt acatggagtg
     1141 ttcagcaaag accaaagacg gagtgagaga ggtttttgag atggccacga gagctgctct
     1201 gcaagctaga cgcgggaaga aaaagtcggg gtgcctcatc ttgtgaagcc ttgtgacgcg
     1261 cagcctcatg cggttaattt gaagtgctgt ttattaatct tagtgtatga ttactggcct
     1321 tttcatttat ctataattta cctaagatta caaatcagaa gtcatcttgc taccagtatt
     1381 tagaagccaa ccatgattat taatgatgtc cagcctgtct gaccagccag ggtccttctg
     1441 acactgctct aacgccctct ctgcactcca cctgacacca ggcgctcatt caaagaattt
     1501 cttaacttcc tgcttctttc tagaaagaga aacagttggt aacttttgtg aattaggctg
     1561 taactacttt ataactaaca tgtcctgcct attttctgtc agctgcgagg aactctggtg
     1621 agtcactact tcagagcttt actccttaac agattccatt ggcagagctc tggggtgggc
     1681 acccagtgtt tggaaacttg atcagccaga aaggcccaag tccacgcagc tgtggcagag
     1741 ttacagttct gtggtctcat gttagttacc ttatagttac tgtgtaatta gtgccactta
     1801 atgtatgtta ccaaaaataa atatatctac cccagactag atgtagtatt ttttgtataa
     1861 ttggatttcc taattctgat atttgtcatt cccacagaaa gtgtattgct tttttttttt
     1921 tttaagaaag tatttggaaa taaagtcaga tggaaaattc atttttaaaa ttcccatttt
     1981 gtcactttct ctgataaaat atggccatat ctcccctatt tagccctata tatcattcca
     2041 gtgccccttt ccagactgga ctgaggaaat aggaattggt ttcatgcctg aggctgttag
     2101 actttggagg tggcatagcc tttctcacct ggactgcagg gcctggctct aagtcacagt
     2161 gctcctttct ccacactgtt atccaagtcg cctcccagag gagccaccag ttcttatggg
     2221 tggcaatggg tgggtgggtg gggggtctcc tctctccagc tgactaaact tttttctgta
     2281 ccagttaatt tttccaacta atagaataaa ggcagttttc taaa
//
LOCUS       NM_001436433            3504 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 4, mRNA.
ACCESSION   NM_001436433 XM_063266244
VERSION     NM_001436433.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3504)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3504)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3504)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3504)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3504)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3504)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3504)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3504)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3504)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3504)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266244.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.485600.1,
                                           SRR26360194.1365682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-472             JAXUCZ010000008.1  28220002-28220231
            473-650             JAXUCZ010000008.1  28220683-28220860
            651-798             JAXUCZ010000008.1  28223540-28223687
            799-890             JAXUCZ010000008.1  28224972-28225063
            891-986             JAXUCZ010000008.1  28225440-28225535
            987-1098            JAXUCZ010000008.1  28226074-28226185
            1099-1196           JAXUCZ010000008.1  28226611-28226708
            1197-1308           JAXUCZ010000008.1  28227262-28227373
            1309-1419           JAXUCZ010000008.1  28227460-28227570
            1420-1619           JAXUCZ010000008.1  28228703-28228902
            1620-1787           JAXUCZ010000008.1  28229217-28229384
            1788-1910           JAXUCZ010000008.1  28230383-28230505
            1911-2087           JAXUCZ010000008.1  28230664-28230840
            2088-2244           JAXUCZ010000008.1  28230937-28231093
            2245-2298           JAXUCZ010000008.1  28231210-28231263
            2299-2664           JAXUCZ010000008.1  28234392-28234757
            2665-2793           JAXUCZ010000008.1  28235346-28235474
            2794-3504           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3504
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2930
                     /gene="Ilf3"
                     /note="isoform 4 is encoded by transcript variant 4; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 4"
                     /protein_id="NP_001423362.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSV
                     FPSDATTEGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQ
                     GAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFGM
                     GGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNSA
                     TAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGGQ
                     QKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGGG
                     GSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGGSSSYQGKQGGYSS
                     QSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     misc_feature    393..494
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    438..440
                     /gene="Ilf3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    537..539
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    801..803
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    807..809
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1182..1184
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1326..1442
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1350..1406
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1383..1385
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1389..1391
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1617..1619
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    1665..1667
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1668..1670
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1683..1685
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1695..1697
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1794..2009
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1794..2009
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1815..1817,1821..1826,1833..1835,1872..1874,
                     1881..1889,1899..1901,1947..1958)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1815..1817,1821..1826,1833..1835,1872..1874,
                     1881..1889,1899..1901,1947..1958)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    2061..2927
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Interaction with PRMT1"
     misc_feature    2106..2222
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2394..2927
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2616..2618
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2670..2672
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2676..2678
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2688..2690
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     exon            243..472
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..650
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..798
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..890
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..986
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1098
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1196
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1308
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1619
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1787
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1910
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2087
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2244
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2298
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2664
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2793
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3504
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tgcgtcccat gagaattttt gtgaatgatg atcgccatgt gatggcaaag cattcttcag
      301 tatacccaac acaagaggag ctggaggctg tacagaacat ggtgtcccac actgagcggg
      361 ccctcaaggc tgtctctgac tggattgatg agcaggagaa aggcaacagc gagctctctg
      421 aagcagaaaa tatggacaca cccccagatg atgagagcaa agaaggggct ggggaacaga
      481 aggcggaaca catgactagg accctgaggg gcgtgatgcg ggtcggcctg gtagccaagg
      541 gtcttctgct caagggggac ttggatctgg agctggttct gctctgtaag gagaagccca
      601 caactgccct tctggacaag gtggctgaca acctggccat ccagcttact actgtaacag
      661 aagacaagta tgaaatactc caatctgtgg atgatgctgc gattgtgata aaaaacacaa
      721 aagagccccc cttgtccttg accatccatc tgacctcccc tgttgtcaga gaagaaatgg
      781 agaaagtatt agctggagaa acgctatcag tcaacgaccc cccggacgtt ctggacaggc
      841 agaaatgcct tgctgccttg gcgtccctcc gacacgccaa gtggttccag gctagagcca
      901 atgggctgaa gtcatgtgtc attgtcatcc gtgtcctaag ggacttgtgt acccgagtgc
      961 ccacctgggg tcctctcaga ggatggcctc tggagctgct gtgtgagaag tccatcggca
     1021 ctgccaatag gccaatgggt gctggtgaag ccctgcggag agtactggag tgcctggctt
     1081 ccggcatcgt aatgccagat ggttctggca tttatgaccc ttgtgaaaaa gaagccactg
     1141 atgctattgg gcatctagac agacagcaac gggaagatat cacacagagt gcgcagcatg
     1201 ctctgcggct tgctgccttt ggccagctcc ataaagtact gggaatggac ccactgcctt
     1261 ccaaaatgcc caagaaacca aagaacgaga acccggtgga ctatactgtt caaatccccc
     1321 ccagcaccac ctacgccatc acacccatga aacgccctat ggaagaagat ggggaggaga
     1381 agtctcccag caaaaagaaa aagaagatcc agaagaaaga ggagaaggct gagcctcccc
     1441 aagctatgaa tgccctgatg aggttaaacc agctgaagcc agggctacag tacaagctga
     1501 tctcccagac gggtcctgtt cacgctccca tcttcaccat gtctgtggag gtagacggca
     1561 gtacctttga ggcctcaggg ccatctaaaa agaccgccaa gctacatgtg gctgtgaagg
     1621 tgttacagga catgggattg ccaacaggcg ctgaaggcag agactccagc aagggggagg
     1681 actctgctga ggagtcagat gggaagccag cagtagtggc cccaccccct gtggtggaag
     1741 cagtctccaa ccccagttct gtcttccctt cagatgccac tactgagggg ccgattttga
     1801 ctaagcacgg caagaatcct gtaatggagc ttaatgagaa gagacgtggc ctcaaatatg
     1861 agctcatttc tgagacaggg ggcagccacg acaaacggtt tgttatggag gttgaggtgg
     1921 acggacagaa gtttcaaggt gctggctcaa acaaaaaggt agcaaaggct tatgctgcac
     1981 ttgccgcatt agagaagctt ttccctgacg cccctcttgc tcttgaagcc aacaagaaga
     2041 aaagagcccc tgtgcctgtc cgaggcggac ccaaatttgc tgccaagcca cataaccctg
     2101 gctttggcat gggaggcccc atgcataatg aagcgccccc acctcccaac atccgaggtc
     2161 ggggccgagg aggtaacatc cgagggcgag gacgggggcg aggatttggt ggcaccaacc
     2221 acggaggagg ctacatgaat gctggcgctg gatatggaag ctatgggtac agcagcaatt
     2281 cggccacagc aggctacagt cagttctaca gcaatggagg gcattctggg aatgccggtg
     2341 gtggaggcag cgggggaggt ggtggctcgt ccagctacag ctcctactac caaggagaca
     2401 gctacaactc accagtgccc ccgaaacatg ctgggaagaa gccgctgcat gggggccagc
     2461 agaaaccctc ctacagctcg ggctaccagt cccaccaggg ccagcagcaa ccttacaacc
     2521 agagccagta cagcagctac ggcacgccac agggcaagca gaaaggctat ggccatgggc
     2581 agggcagcta ctcctcctac tccaactctt acaactcccc tggtggtggt gggggctctg
     2641 actacagcta cgacagcaaa ttcaactaca gtggtagtgg aggccggagt ggagggaaca
     2701 gctatggctc cagcgggtca tcctacaaca caggctcaca tgggggttat ggcgcaggtt
     2761 ctggaggcag ctcttcatac caaggcaaac aaggaggcta ctcatcacag tcaaactaca
     2821 gctcccctgg gtccagccag agctacagcg gccccgccag ctcctaccag tcctcacagg
     2881 gtggctacag tcggaacaca gaacacagca tgaactacca gtacagataa aggcccaggc
     2941 tgcccctctc aaccttctgc acctctgcct ccaacttgtc tcgggagatt gagtctgcac
     3001 atcaccagtt gccatgtcca ctgggccagt gcccacccgt ccacgttgct gacgttgcca
     3061 cgctgtgagg cgtggtggtc cctgggaccc gtgctgtgac cctatttagc tgtgttttgg
     3121 actcagtgtc ttcagtggtt tgttagttac cattacacct tgtctgagta gtgttccgag
     3181 ttcttgccgt gcggaatccc tctgtctgtt tatgcccggt gtgagttcca tcgggtgtct
     3241 ttaaatagtt gcagaaggga tacgtcatct gttaatgctt tttgtgaagt gagttaaatg
     3301 agctttcatt attttaatgc ttagtgtttc agttttataa gtgaaaattt tattttaaaa
     3361 aacagtgggg tttgtttttt tgtttttttg tctttgtttt tgtttttttt tttttttttt
     3421 tttttttttt tggtatgtct ggatcattca ggcagtacat ttgaattccg ctgaatgtag
     3481 ataaataaaa gaaaaacaaa acag
//
LOCUS       NM_001436437            3653 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 8, mRNA.
ACCESSION   NM_001436437 XM_063266249
VERSION     NM_001436437.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266249.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32697.1,
                                           SRR26643293.44135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-472             JAXUCZ010000008.1  28220002-28220231
            473-650             JAXUCZ010000008.1  28220683-28220860
            651-798             JAXUCZ010000008.1  28223540-28223687
            799-890             JAXUCZ010000008.1  28224972-28225063
            891-986             JAXUCZ010000008.1  28225440-28225535
            987-1098            JAXUCZ010000008.1  28226074-28226185
            1099-1196           JAXUCZ010000008.1  28226611-28226708
            1197-1308           JAXUCZ010000008.1  28227262-28227373
            1309-1419           JAXUCZ010000008.1  28227460-28227570
            1420-1619           JAXUCZ010000008.1  28228703-28228902
            1620-1787           JAXUCZ010000008.1  28229217-28229384
            1788-1913           JAXUCZ010000008.1  28230380-28230505
            1914-2090           JAXUCZ010000008.1  28230664-28230840
            2091-2247           JAXUCZ010000008.1  28230937-28231093
            2248-2301           JAXUCZ010000008.1  28231210-28231263
            2302-3653           JAXUCZ010000008.1  28231704-28233055
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3653
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2351
                     /gene="Ilf3"
                     /note="isoform 8 is encoded by transcript variant 8; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 8"
                     /protein_id="NP_001423366.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSV
                     FPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKF
                     QGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFG
                     MGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNS
                     ATAGYSDFFTDCYGYHDFGAS"
     misc_feature    393..494
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    438..440
                     /gene="Ilf3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    537..539
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    801..803
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    807..809
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1182..1184
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1326..1442
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1350..1406
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1383..1385
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1389..1391
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1617..1619
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    1635..1811
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1665..1667
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1668..1670
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1683..1685
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1695..1697
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1797..2012
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1797..2012
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1818..1820,1824..1829,1836..1838,1875..1877,
                     1884..1892,1902..1904,1950..1961)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1818..1820,1824..1829,1836..1838,1875..1877,
                     1884..1892,1902..1904,1950..1961)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    2109..2225
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            243..472
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..650
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..798
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..890
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..986
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1098
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1196
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1308
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1619
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1787
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1913
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2090
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2247
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2301
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..3653
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tgcgtcccat gagaattttt gtgaatgatg atcgccatgt gatggcaaag cattcttcag
      301 tatacccaac acaagaggag ctggaggctg tacagaacat ggtgtcccac actgagcggg
      361 ccctcaaggc tgtctctgac tggattgatg agcaggagaa aggcaacagc gagctctctg
      421 aagcagaaaa tatggacaca cccccagatg atgagagcaa agaaggggct ggggaacaga
      481 aggcggaaca catgactagg accctgaggg gcgtgatgcg ggtcggcctg gtagccaagg
      541 gtcttctgct caagggggac ttggatctgg agctggttct gctctgtaag gagaagccca
      601 caactgccct tctggacaag gtggctgaca acctggccat ccagcttact actgtaacag
      661 aagacaagta tgaaatactc caatctgtgg atgatgctgc gattgtgata aaaaacacaa
      721 aagagccccc cttgtccttg accatccatc tgacctcccc tgttgtcaga gaagaaatgg
      781 agaaagtatt agctggagaa acgctatcag tcaacgaccc cccggacgtt ctggacaggc
      841 agaaatgcct tgctgccttg gcgtccctcc gacacgccaa gtggttccag gctagagcca
      901 atgggctgaa gtcatgtgtc attgtcatcc gtgtcctaag ggacttgtgt acccgagtgc
      961 ccacctgggg tcctctcaga ggatggcctc tggagctgct gtgtgagaag tccatcggca
     1021 ctgccaatag gccaatgggt gctggtgaag ccctgcggag agtactggag tgcctggctt
     1081 ccggcatcgt aatgccagat ggttctggca tttatgaccc ttgtgaaaaa gaagccactg
     1141 atgctattgg gcatctagac agacagcaac gggaagatat cacacagagt gcgcagcatg
     1201 ctctgcggct tgctgccttt ggccagctcc ataaagtact gggaatggac ccactgcctt
     1261 ccaaaatgcc caagaaacca aagaacgaga acccggtgga ctatactgtt caaatccccc
     1321 ccagcaccac ctacgccatc acacccatga aacgccctat ggaagaagat ggggaggaga
     1381 agtctcccag caaaaagaaa aagaagatcc agaagaaaga ggagaaggct gagcctcccc
     1441 aagctatgaa tgccctgatg aggttaaacc agctgaagcc agggctacag tacaagctga
     1501 tctcccagac gggtcctgtt cacgctccca tcttcaccat gtctgtggag gtagacggca
     1561 gtacctttga ggcctcaggg ccatctaaaa agaccgccaa gctacatgtg gctgtgaagg
     1621 tgttacagga catgggattg ccaacaggcg ctgaaggcag agactccagc aagggggagg
     1681 actctgctga ggagtcagat gggaagccag cagtagtggc cccaccccct gtggtggaag
     1741 cagtctccaa ccccagttct gtcttccctt cagatgccac tactgagcag gggccgattt
     1801 tgactaagca cggcaagaat cctgtaatgg agcttaatga gaagagacgt ggcctcaaat
     1861 atgagctcat ttctgagaca gggggcagcc acgacaaacg gtttgttatg gaggttgagg
     1921 tggacggaca gaagtttcaa ggtgctggct caaacaaaaa ggtagcaaag gcttatgctg
     1981 cacttgccgc attagagaag cttttccctg acgcccctct tgctcttgaa gccaacaaga
     2041 agaaaagagc ccctgtgcct gtccgaggcg gacccaaatt tgctgccaag ccacataacc
     2101 ctggctttgg catgggaggc cccatgcata atgaagcgcc cccacctccc aacatccgag
     2161 gtcggggccg aggaggtaac atccgagggc gaggacgggg gcgaggattt ggtggcacca
     2221 accacggagg aggctacatg aatgctggcg ctggatatgg aagctatggg tacagcagca
     2281 attcggccac agcaggctac agtgactttt tcacagactg ctacggctat catgattttg
     2341 gggcttccta gagcgtctaa aagtattgac acaaaatcaa ctttttactc caatttcctc
     2401 caactccaaa acccaaagtg tccgtgctgt gtccctgtgc ttcactgggg ttctcaaccg
     2461 tggctttcca ccgcagcctg tctgaaactg ttagcctgca gacttaagac aatggcagtt
     2521 tctatcatga gtttgccttt gaacttggtc atttcgaagt tcacactaag tggaaaaacc
     2581 cttttctcag agaatttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2641 tagccttgca cagaattcta gagccagcgt tgttcagcat caaggcaaaa gcccatcatt
     2701 gctttttatg gaaagcattc ttttatttaa agaaacagat aatggcacgt tttaatctac
     2761 ctttgtctta atttacagca ggttttgtat gcaattttta accttttcac aagttttcac
     2821 atctggttga tgcctttggc agtgatgaaa actttcagca catctgaatc cacagcagct
     2881 gacttttttc cttgcctttt gaatgagcat gtaaacctct gggatggcca gaacttgtgt
     2941 actgcgtaga gcagggcctc ccaccttttg taaatgctct ggtgggtcct tggggtgagg
     3001 aggttctgtg gctgctttag ttaagagagt gaacttgcaa aggcatcaaa actgcgcttc
     3061 cgttacttgt gtgagaaatg agacaggctt gagaggaggg aataacgtaa aattttgcaa
     3121 gtcctgattg cagcgtggac tcctggattg ggtttggctt tgttttcttt ttcacaatgg
     3181 ggctttaaaa ctgagctgga ggagcctgac acatcccacc ctttttttcc cccagcaaat
     3241 tgctgacttt ggcccgacca gggtctatac tgcctggcac acagacactg aatctgtgtg
     3301 cctagaattt gtcccagtgt gtaaagtggt ggggagcctt gtgatattgt ggttaggcct
     3361 ctgctttgta gtttttgctg cagatttgcc cctgccttga cttgcaagat ttgacgttta
     3421 ttcaggcaaa aagtggtcaa aatggttact gtgtgatttg ttccccaagg tttaaaaagt
     3481 cagtgaaact ttctaagatt ttgcatgatg tattttattt tatttttatt ttttagaaag
     3541 ttcttgttgg caaataatgt ctttttatac caggaaatag ttctgaatga cgttgaagac
     3601 cttcccttcc ttattactat tattttttaa atgaatacat gttaaagtaa tga
//
LOCUS       NM_001436427            2539 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled estrogen receptor 1 (Gper1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436427
VERSION     NM_001436427.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Zhang,Y.Q., Sun,T., Zhao,Z., Fu,J., Yang,L., Xu,Y., Zhao,J.F.,
            Tang,X.L., Liu,A. and Zhao,M.G.
  TITLE     Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion
            Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling
            Pathway
  JOURNAL   Neuromolecular Med 26 (1), 33 (2024)
   PUBMED   39138706
  REMARK    GeneRIF: Activation of GPR30 Ameliorates Cerebral
            Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through
            Nrf2/GPX4 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Grubic Kezele,T., Omrcen,H., Baticic,L., Sucurovic,S. and Zoricic
            Cvek,S.
  TITLE     Joint Inflammation Correlates with Joint GPR30 Expression in Males
            and Hippocampal GPR30 Expression in Females in a Rat Model of
            Rheumatoid Arthritis
  JOURNAL   Int J Mol Sci 25 (14), 7864 (2024)
   PUBMED   39063107
  REMARK    GeneRIF: Joint Inflammation Correlates with Joint GPR30 Expression
            in Males and Hippocampal GPR30 Expression in Females in a Rat Model
            of Rheumatoid Arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Azizian,H., Farhadi,Z., Bader,M., Alizadeh Ghalenoei,J.,
            Ghafari,M.A. and Mahmoodzadeh,S.
  TITLE     GPER activation attenuates cardiac dysfunction by upregulating the
            SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats
  JOURNAL   PLoS One 18 (12), e0293630 (2023)
   PUBMED   38134189
  REMARK    GeneRIF: GPER activation attenuates cardiac dysfunction by
            upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Hu,J., Huang,Y., Gao,F., Sun,W., Liu,H., Ma,H., Yuan,T., Liu,Z.,
            Tang,L., Ma,Y., Zhang,X., Bai,J. and Wang,R.
  TITLE     Brain-derived estrogen: a critical player in maintaining cognitive
            health of aged female rats, possibly involving GPR30
  JOURNAL   Neurobiol Aging 129, 15-27 (2023)
   PUBMED   37257405
  REMARK    GeneRIF: Brain-derived estrogen: a critical player in maintaining
            cognitive health of aged female rats, possibly involving GPR30.
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Xu,X., Wang,J., Guo,X., Chen,Y., Ding,S., Zou,G., Zhu,L., Li,T. and
            Zhang,X.
  TITLE     GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2
  JOURNAL   Front Immunol 14, 1106771 (2023)
   PUBMED   36845134
  REMARK    GeneRIF: GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Sakamoto,H., Matsuda,K., Hosokawa,K., Nishi,M., Morris,J.F.,
            Prossnitz,E.R. and Kawata,M.
  TITLE     Expression of G protein-coupled receptor-30, a G protein-coupled
            membrane estrogen receptor, in oxytocin neurons of the rat
            paraventricular and supraoptic nuclei
  JOURNAL   Endocrinology 148 (12), 5842-5850 (2007)
   PUBMED   17872373
  REMARK    GeneRIF: Results suggest that GPR30 may serve primarily as a
            nongenomic transducer of estrogen actions in the
            hypothalamo-neurohypophyseal system.
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Funakoshi,T., Yanai,A., Shinoda,K., Kawano,M.M. and Mizukami,Y.
  TITLE     G protein-coupled receptor 30 is an estrogen receptor in the plasma
            membrane
  JOURNAL   Biochem Biophys Res Commun 346 (3), 904-910 (2006)
   PUBMED   16780796
  REMARK    GeneRIF: GPR30, a transmembrane receptor for estrogen, is localized
            to the plasma membrane of CA2 pyramidal neuronal cells of the
            hippocampus in rat brain
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Revankar,C.M., Cimino,D.F., Sklar,L.A., Arterburn,J.B. and
            Prossnitz,E.R.
  TITLE     A transmembrane intracellular estrogen receptor mediates rapid cell
            signaling
  JOURNAL   Science 307 (5715), 1625-1630 (2005)
   PUBMED   15705806
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   Thomas,P., Pang,Y., Filardo,E.J. and Dong,J.
  TITLE     Identity of an estrogen membrane receptor coupled to a G protein in
            human breast cancer cells
  JOURNAL   Endocrinology 146 (2), 624-632 (2005)
   PUBMED   15539556
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Bonini,J.A., Anderson,S.M. and Steiner,D.F.
  TITLE     Molecular cloning and tissue expression of a novel orphan G
            protein-coupled receptor from rat lung
  JOURNAL   Biochem Biophys Res Commun 234 (1), 190-193 (1997)
   PUBMED   9168987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.596012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680428,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000012.1  20335552-20335727   c
            177-361             JAXUCZ010000012.1  20335067-20335251   c
            362-2539            JAXUCZ010000012.1  20331073-20333250   c
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2539
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
     exon            1..176
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     exon            177..361
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     exon            362..2539
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    567..569
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="upstream in-frame stop codon"
     CDS             588..1715
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="mER; chemokine receptor-like 2; membrane estrogen
                     receptor; G-protein coupled receptor 30; G-protein coupled
                     receptor 41; chemoattractant receptor-like 2"
                     /codon_start=1
                     /product="G-protein coupled estrogen receptor 1"
                     /protein_id="NP_001423356.1"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
                     /translation="MAATTPAQDVGVEIYLGPVWPAPSNSTPLALNLSLALREDAPGN
                     LTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLA
                     AADLILVADSLIEVFNLDEQYYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALA
                     KAMRCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLRHTEEACFCFADVREVQWLE
                     VTLGFIVPFAIIGLCYSLIVRALIRAHRHRGLRPRRQKALRMIFAVVLVFFICWLPEN
                     VFISVHLLQWAQPGDTPCKQSFRHAYPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDK
                     LRLYVAQKTSLPALNRFCHATLKAVIPDSTEQSDVKFSSAV"
     misc_feature    588..590
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q99527; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); acetylation site"
     misc_feature    681..683
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); glycosylation site"
     misc_feature    717..719
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); glycosylation site"
     misc_feature    765..1592
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPER1; cd14989"
                     /db_xref="CDD:320120"
     misc_feature    765..1592
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPER1; cd14989"
                     /db_xref="CDD:320120"
     misc_feature    768..848
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320120"
     misc_feature    768..848
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320120"
     misc_feature    774..839
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    867..944
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320120"
     misc_feature    867..944
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320120"
     misc_feature    876..947
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    order(930..932,939..944,975..992,996..1001,1008..1010,
                     1143..1145,1149..1163,1218..1220,1227..1235,1239..1247,
                     1251..1256,1401..1403,1410..1415,1419..1424,1431..1433,
                     1491..1496,1500..1508,1515..1517,1524..1529)
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320120"
     misc_feature    order(930..932,939..944,975..992,996..1001,1008..1010,
                     1143..1145,1149..1163,1218..1220,1227..1235,1239..1247,
                     1251..1256,1401..1403,1410..1415,1419..1424,1431..1433,
                     1491..1496,1500..1508,1515..1517,1524..1529)
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320120"
     misc_feature    975..1067
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320120"
     misc_feature    975..1067
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320120"
     misc_feature    984..1046
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1104..1169
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320120"
     misc_feature    1104..1169
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320120"
     misc_feature    1113..1169
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1218..1301
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320120"
     misc_feature    1218..1301
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320120"
     misc_feature    1248..1295
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1341..1433
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320120"
     misc_feature    1341..1433
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320120"
     misc_feature    1365..1427
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1494..1571
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320120"
     misc_feature    1494..1571
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320120"
     misc_feature    1506..1568
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
ORIGIN      
        1 acaggcatcc acaggcatgg tgagcctgct cccttccaga cctgacactc ttcttttcct
       61 ctcctgctgt atccctgctg ggcaccatcc ccaaggtgct acgagtccag ggacaatccc
      121 tgtgagcaac ctccagaagc acctccagca gatggttcag tgactccatg gcccagatct
      181 ggacacacaa cagaaaatca ggatactaat attgatcatt agattaagag agcagcagtt
      241 gggaccaagg acagaagcct gggtgtcatt tctgtcatgc atccaccaga acagttgatc
      301 agatctaggg agaaagccat ctgagggatt gtggccaagc ctcatcattc acacattctg
      361 agtcctcaga aggtaagcag gcagcaggcg ttcctgcccg gcaccagccc agacgccctg
      421 tctgcccttc tggttttctg agacaaacag gctcccagga cgattcttcc tgcctcacgc
      481 atgcctggct cacttcccag ggaatcacct ttgtgaagat ggagctgtca cgtaaaacag
      541 acttctgtga ccctttcagc aagtcctgaa agcttctacg ggaagccatg gctgcaacta
      601 ctccagcaca agatgttggc gtagagatct acctaggtcc cgtgtggcca gccccttcca
      661 acagcacccc tctggccctc aacctgtccc tggcgctgcg ggaagatgcc ccggggaacc
      721 tcactgggga cctctctgaa catcagcaat atgtgatcgc tctcttcctc tcctgcctct
      781 acaccatctt cctcttcccc atcggctttg tgggcaacat cctcatcttg gtggtgaaca
      841 tcagcttccg ggagaagatg actatcccag acctgtactt catcaacctg gcagcggccg
      901 acctcatcct ggtggccgac tccctgatcg aggtgttcaa cctggacgag cagtactacg
      961 atatcgccgt gctctgcacc ttcatgtccc tcttcctgca gatcaacatg tacagcagcg
     1021 tcttcttcct cacctggatg agcttcgaca ggtacctggc gctggccaaa gccatgcgct
     1081 gtggcctctt ccgcaccaag caccacgcgc ggctcagctg tggcctcatc tggatggcct
     1141 cagtgtccgc cacgctggtg cccttcacgg ccgtgcatct gcggcacacc gaggaggcct
     1201 gcttctgctt tgccgatgtc agggaggtgc agtggctgga ggtcacgctg ggcttcattg
     1261 tgcccttcgc catcatcggc ctgtgctatt ccctcatcgt gcgggccctc atccgggccc
     1321 acaggcatcg tggcctgcgc ccacgcaggc agaaagccct gaggatgatc ttcgcagtgg
     1381 tccttgtctt cttcatctgc tggctgccgg agaacgtctt catcagcgtc cacctactgc
     1441 agtgggcgca gccaggggac actccctgca agcagtcttt ccgtcatgcc taccccttga
     1501 caggccacat agtcaacctg gcagccttct ccaacagctg cctgaatccc ctcatctata
     1561 gcttcctggg agagaccttc agggacaagc tcaggctgta tgtggcgcag aagacgagcc
     1621 tgccagctct caaccgcttc tgccatgcca cgctcaaggc agtcatacca gacagcacgg
     1681 agcagtcaga tgtcaagttc agcagtgctg tatgagaggt acctcctaga ggaaaacgga
     1741 caggggagca ggcgtgccca ggagctgcac actcctagca caggtggtgg gcgagctgag
     1801 ccatgtcata ctctaaaccc cagtggctag ggggaaatgt cacatggctg ggtcacctct
     1861 ggggctgctg ggattcttcc tgactgccca gctcatggat actgccatcc agattcaagg
     1921 cagtgggcca catgacattg acctctgccc tcaaagggca ccacgaaggc ctgacgcttg
     1981 gttttctttc cataccctat gtttccagaa gacaagtctg ttgttgatta agtaacagcc
     2041 caaaggacag gccaccctat ggcactacca tggttatatc ttctgttacg tgcctgctac
     2101 acggaagagc ctagaaacag agcatatgta ccagacccaa actggctacg ttccctttgc
     2161 ttgtgacgtg tgattgatca tgtacactct gtccagtgca gccaaagcta aggaccccag
     2221 agccttcttc ctgtcttcca gaaggctgtg aggtcatccc agatgccact cctaactcct
     2281 cagtgaacag catgtctgag ctgagaaagg ccctttaaca aaccacctcc ctgctctggg
     2341 atgctcctct cacaaagctt gtttacaaag gtgtttgccc ttctgtgaag gtggaaggag
     2401 accgtgggtg ctgctgtgca ggctgctggg aatcccatca taagacattt gtcggaagga
     2461 cttgactcca cagaaaataa tactgggaac ggtgagctgt aaacggatct cattaaaatg
     2521 taaaaagaaa gaacaagaa
//
LOCUS       NM_001436443            2010 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 3, mRNA.
ACCESSION   NM_001436443 XM_063264787
VERSION     NM_001436443.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2010)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 2010)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 2010)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2010)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 2010)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 2010)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 2010)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 2010)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 2010)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 2010)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063264787.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.24258.1,
                                           SRR26360186.2289072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  117870535-117870689
            156-230             JAXUCZ010000008.1  117880565-117880639
            231-348             JAXUCZ010000008.1  117892021-117892138
            349-506             JAXUCZ010000008.1  117894634-117894791
            507-627             JAXUCZ010000008.1  117897631-117897751
            628-758             JAXUCZ010000008.1  117901968-117902098
            759-2010            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..2010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2010
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..155
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..230
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..348
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    324..326
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            349..506
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..932
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423372.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     351..920
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    363..887
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    363..887
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(363..365,450..452,459..464,471..473,477..479,
                     483..485,510..512,522..527,531..539,546..548,552..554,
                     564..566)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(363..365,450..452,459..464,471..473,477..479,
                     483..485,510..512,522..527,531..539,546..548,552..554,
                     564..566)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    384..407
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    384..407
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(393..410,450..455,459..461,525..530,702..704,
                     708..710,831..836)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(393..410,450..455,459..461,525..530,702..704,
                     708..710,831..836)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(417..419,423..437,474..479,483..491,504..512,
                     837..842,852..857,864..866)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(417..419,423..437,474..479,483..491,504..512,
                     837..842,852..857,864..866)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(450..452,456..458,462..467,537..548,555..557,
                     564..566,630..632)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(450..452,456..458,462..467,537..548,555..557,
                     564..566,630..632)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    450..476
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    450..476
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    450..476
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(459..464,531..533,546..548,552..557,561..566,
                     573..575,663..668,672..674)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(459..464,531..533,546..548,552..557,561..566,
                     573..575,663..668,672..674)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    459..461
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    459..461
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(465..467,543..557,564..566,639..641,651..653,
                     663..665)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(465..467,543..557,564..566,639..641,651..653,
                     663..665)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(465..470,543..548,552..557,564..566)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(465..470,543..548,552..557,564..566)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    525..536
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    525..536
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    531..584
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    534..587
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    534..587
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    699..710
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    699..710
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    828..836
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    828..836
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    912..914
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    918..920
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            507..627
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..758
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..2010
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgcgctc cccgcccgcc gcccgcggtc ctccgtcggt tctctcctta gcccgccgtc
       61 tcccacggag ctgctcgccc ttgtctcgga gctcgcggac tcgcggacag gcgtcctcag
      121 cgcgaagagg ccggattcgg agtcgtcgtc ttgagccttg catctaagaa gtcccaggta
      181 ctttgtacaa ctgcatccca gaagctgagt ttcttcagca ccttcataag atccctggaa
      241 ttggagttgc agatggttgt gagccatcat gtgggtgctg agaactgaac ccttcctctg
      301 caagaacaag tgctcttaac cactgagcca tctctggctc cctcagagtg atggctgcca
      361 tcaggaagaa actggtgatt gttggtgatg gagcttgtgg taagacatgc ttgctcatag
      421 tcttcagcaa ggaccagttc ccagaggttt atgtgcccac ggtgtttgaa aactatgtgg
      481 cagatattga agtggacggg aagcaggtag agttggcttt atgggacaca gctggacagg
      541 aagattatga ccgtctgagg cctctctcct acccagacac tgatgttata ctgatgtgtt
      601 tttccatcga cagccctgat agtttagaaa acatcccaga aaaatggact ccagaagtca
      661 agcatttctg tccaaatgtg cccatcatcc tagttgggaa caagaaggat cttcggaatg
      721 atgagcacac aaggcgggag ttagccaaaa tgaagcagga gccggtaaaa cctgaagaag
      781 gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca gcaaagacca
      841 aagacggagt gagagaggtt tttgagatgg ccacgagagc tgctctgcaa gctagacgcg
      901 ggaagaaaaa gtcggggtgc ctcatcttgt gaagccttgt gacgcgcagc ctcatgcggt
      961 taatttgaag tgctgtttat taatcttagt gtatgattac tggccttttc atttatctat
     1021 aatttaccta agattacaaa tcagaagtca tcttgctacc agtatttaga agccaaccat
     1081 gattattaat gatgtccagc ctgtctgacc agccagggtc cttctgacac tgctctaacg
     1141 ccctctctgc actccacctg acaccaggcg ctcattcaaa gaatttctta acttcctgct
     1201 tctttctaga aagagaaaca gttggtaact tttgtgaatt aggctgtaac tactttataa
     1261 ctaacatgtc ctgcctattt tctgtcagct gcgaggaact ctggtgagtc actacttcag
     1321 agctttactc cttaacagat tccattggca gagctctggg gtgggcaccc agtgtttgga
     1381 aacttgatca gccagaaagg cccaagtcca cgcagctgtg gcagagttac agttctgtgg
     1441 tctcatgtta gttaccttat agttactgtg taattagtgc cacttaatgt atgttaccaa
     1501 aaataaatat atctacccca gactagatgt agtatttttt gtataattgg atttcctaat
     1561 tctgatattt gtcattccca cagaaagtgt attgcttttt ttttttttta agaaagtatt
     1621 tggaaataaa gtcagatgga aaattcattt ttaaaattcc cattttgtca ctttctctga
     1681 taaaatatgg ccatatctcc cctatttagc cctatatatc attccagtgc ccctttccag
     1741 actggactga ggaaatagga attggtttca tgcctgaggc tgttagactt tggaggtggc
     1801 atagcctttc tcacctggac tgcagggcct ggctctaagt cacagtgctc ctttctccac
     1861 actgttatcc aagtcgcctc ccagaggagc caccagttct tatgggtggc aatgggtggg
     1921 tgggtggggg gtctcctctc tccagctgac taaacttttt tctgtaccag ttaatttttc
     1981 caactaatag aataaaggca gttttctaaa
//
LOCUS       NM_001106814            7348 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus tectorin alpha (Tecta), transcript variant 2,
            mRNA.
ACCESSION   NM_001106814 XM_001059588 XM_236124
VERSION     NM_001106814.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7348)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 7348)
  AUTHORS   Mustapha,M., Weil,D., Chardenoux,S., Elias,S., El-Zir,E.,
            Beckmann,J.S., Loiselet,J. and Petit,C.
  TITLE     An alpha-tectorin gene defect causes a newly identified autosomal
            recessive form of sensorineural pre-lingual non-syndromic deafness,
            DFNB21
  JOURNAL   Hum Mol Genet 8 (3), 409-412 (1999)
   PUBMED   9949200
REFERENCE   3  (bases 1 to 7348)
  AUTHORS   Verhoeven,K., Van Laer,L., Kirschhofer,K., Legan,P.K., Hughes,D.C.,
            Schatteman,I., Verstreken,M., Van Hauwe,P., Coucke,P., Chen,A.,
            Smith,R.J., Somers,T., Offeciers,F.E., Van de Heyning,P.,
            Richardson,G.P., Wachtler,F., Kimberling,W.J., Willems,P.J.,
            Govaerts,P.J. and Van Camp,G.
  TITLE     Mutations in the human alpha-tectorin gene cause autosomal dominant
            non-syndromic hearing impairment
  JOURNAL   Nat Genet 19 (1), 60-62 (1998)
   PUBMED   9590290
  REMARK    Erratum:[Nat Genet 1999 Apr;21(4):449]
REFERENCE   4  (bases 1 to 7348)
  AUTHORS   Legan,P.K., Rau,A., Keen,J.N. and Richardson,G.P.
  TITLE     The mouse tectorins. Modular matrix proteins of the inner ear
            homologous to components of the sperm-egg adhesion system
  JOURNAL   J Biol Chem 272 (13), 8791-8801 (1997)
   PUBMED   9079715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced NM_001106814.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000008.1  51676293-51676576   c
            285-349             JAXUCZ010000008.1  51675001-51675065   c
            350-483             JAXUCZ010000008.1  51671726-51671859   c
            484-771             JAXUCZ010000008.1  51668785-51669072   c
            772-909             JAXUCZ010000008.1  51664955-51665092   c
            910-1075            JAXUCZ010000008.1  51664494-51664659   c
            1076-1488           JAXUCZ010000008.1  51660814-51661226   c
            1489-2059           JAXUCZ010000008.1  51654605-51655175   c
            2060-2652           JAXUCZ010000008.1  51652140-51652732   c
            2653-3226           JAXUCZ010000008.1  51650301-51650874   c
            3227-3828           JAXUCZ010000008.1  51644582-51645183   c
            3829-4390           JAXUCZ010000008.1  51634598-51635159   c
            4391-4590           JAXUCZ010000008.1  51627235-51627434   c
            4591-4974           JAXUCZ010000008.1  51622884-51623267   c
            4975-5261           JAXUCZ010000008.1  51620631-51620917   c
            5262-5557           JAXUCZ010000008.1  51618858-51619153   c
            5558-5668           JAXUCZ010000008.1  51615231-51615341   c
            5669-5871           JAXUCZ010000008.1  51613989-51614191   c
            5872-6035           JAXUCZ010000008.1  51612896-51613059   c
            6036-6284           JAXUCZ010000008.1  51612169-51612417   c
            6285-6447           JAXUCZ010000008.1  51607786-51607948   c
            6448-6535           JAXUCZ010000008.1  51606670-51606757   c
            6536-6652           JAXUCZ010000008.1  51606290-51606406   c
            6653-7348           JAXUCZ010000008.1  51604974-51605669   c
FEATURES             Location/Qualifiers
     source          1..7348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..7348
                     /gene="Tecta"
                     /note="tectorin alpha"
                     /db_xref="GeneID:300653"
                     /db_xref="RGD:1309824"
     exon            1..284
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="Tecta"
                     /note="upstream in-frame stop codon"
     exon            285..349
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..6753
                     /gene="Tecta"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; alpha-tectorin"
                     /codon_start=1
                     /product="alpha-tectorin isoform 2 precursor"
                     /protein_id="NP_001100284.2"
                     /db_xref="GeneID:300653"
                     /db_xref="RGD:1309824"
                     /translation="MNYSSLLRIWVSFIFALVRHQAQPRELMYPFWQNDTRTPKVDDG
                     SSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWAD
                     VHNGIRGEIYYRETMDSAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSST
                     TPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTN
                     FFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDD
                     LNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFD
                     GFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVNGYKILI
                     PKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIP
                     GSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHTDWKCGSGCIDNCT
                     QCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQ
                     AIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQNCA
                     TPCTEGCECNEGFVLSTSQCVPLHKCGCDFEGHYYTMGEFFWATANCTVQCLCEEGGD
                     VYCFNKTCRSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLL
                     KTCPERPEYLEIDINKRKPDAGPAWLRGVRILVADQEVKIGGVGALEVKLNGQDVELP
                     FFHPSGRLEIHRNKNSTTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANA
                     SDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGI
                     INDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVG
                     PWRTYDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQC
                     VTRSECGCNFEGHQLATNETFWVDQDCQIFCYCNGTDNSVHCETIPCRDDDYCMEESG
                     LYYCQPRTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRSISDSFPKFIVTAK
                     NEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNNERLYLPLKLGQGKINIFSFG
                     FHVVVETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPGDDLEMPMGLLALS
                     INEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHSKVNP
                     TFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSCSVTCPPNSHY
                     ESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHNCGCYSDGKYYEP
                     KQLFWNGDCTRRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCFSTKTSYCLAAGGGV
                     FRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEE
                     QILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISI
                     SERLQNKVCGLCGNFNGDMTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLTPSCNEL
                     QFSQYAATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNHK
                     KFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELDNGGELC
                     GCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSGIEG
                     EDFISFQINNTKGNCGNVVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAY
                     ELDIKISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDV
                     LYVGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGV
                     SLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYSKEHKEQI
                     ISVGPIRRKRLDWCEDNGGCEQVCTSRVDGPLCSCVTGSLQEDGRSCRASNSSVEPQV
                     WTLLLIMTQISLWHFVYQSGATS"
     sig_peptide     286..357
                     /gene="Tecta"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    577..1047
                     /gene="Tecta"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; Region: NIDO;
                     smart00539"
                     /db_xref="CDD:214712"
     misc_feature    577..1047
                     /gene="Tecta"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; Region: NIDO;
                     smart00539"
                     /db_xref="CDD:214712"
     misc_feature    1222..1716
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    1222..1716
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    1834..2058
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    1834..2058
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    2074..2235
                     /gene="Tecta"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     Region: TIL; pfam01826"
                     /db_xref="CDD:460351"
     misc_feature    2074..2235
                     /gene="Tecta"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     Region: TIL; pfam01826"
                     /db_xref="CDD:460351"
     misc_feature    order(2101..2103,2113..2115,2152..2154,2164..2166)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(2101..2103,2113..2115,2152..2154,2164..2166)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    2239..2403
                     /gene="Tecta"
                     /note="von Willebrand factor type C domain; Region: VWC;
                     cl17735"
                     /db_xref="CDD:450195"
     misc_feature    2239..2403
                     /gene="Tecta"
                     /note="von Willebrand factor type C domain; Region: VWC;
                     cl17735"
                     /db_xref="CDD:450195"
     misc_feature    2392..2880
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    2392..2880
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    2998..3228
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    2998..3228
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    3235..3393
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    3235..3393
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    order(3262..3264,3271..3273,3310..3312,3322..3324)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(3262..3264,3271..3273,3310..3312,3322..3324)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    3583..4059
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    3583..4059
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    4183..4389
                     /gene="Tecta"
                     /note="C8 domain; Region: C8; pfam08742"
                     /db_xref="CDD:462584"
     misc_feature    4183..4389
                     /gene="Tecta"
                     /note="C8 domain; Region: C8; pfam08742"
                     /db_xref="CDD:462584"
     misc_feature    4399..4560
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    4399..4560
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    order(4426..4428,4438..4440,4477..4479,4489..4491)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(4426..4428,4438..4440,4477..4479,4489..4491)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    4744..5202
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    4744..5202
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    5338..5556
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    5338..5556
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    5698..6462
                     /gene="Tecta"
                     /note="Zona pellucida (ZP) domain; Region: ZP; smart00241"
                     /db_xref="CDD:214579"
     misc_feature    5698..6462
                     /gene="Tecta"
                     /note="Zona pellucida (ZP) domain; Region: ZP; smart00241"
                     /db_xref="CDD:214579"
     misc_feature    6550..6648
                     /gene="Tecta"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    6550..6648
                     /gene="Tecta"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     exon            350..483
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            484..771
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            772..909
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1075
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1488
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2059
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2652
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..3226
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3828
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4390
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4590
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4974
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5261
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5557
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5558..5668
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5871
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5872..6035
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6036..6284
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6285..6447
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6448..6535
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6536..6652
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..7348
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaaagag cctctccatg caatcctgaa accgatcttc agatttcctt ttccttaatc
       61 aatagaaagc aacttgattg caactcaaca ctcccccgac tctagtgcag gactaactga
      121 atttttggtt ttaagagtat gggattcgga cgtgattcca gggatcagaa ataattgaca
      181 gtcacgcaag gagaactgac gtgaattctt atacctaatt ttccgggctc accaagattt
      241 gagttaatac ttttcactca attcctccag tctcgactga acaggatgaa ttattcatca
      301 ttacttagaa tttgggtctc tttcatcttc gctcttgttc ggcaccaagc tcagcccagg
      361 gagctcatgt atccattttg gcagaatgac accagaaccc ctaaagtaga cgacggaagc
      421 tcatctgaga ttaagttggc catccctgtc ttcttctttg gtgttcctta ccgcactgtc
      481 tatgttaata acaacggtgt tgtttccttc aacgtgctag tgagccagtt tacgccagag
      541 tcctttcccc tgacggatgg gagggccttc attgctccgt tttgggcaga cgtgcacaac
      601 ggaattcggg gtgagatcta ttacagagaa accatggact ctgccatctt gagaagagcc
      661 accaaggaca tcaggaagta cttcaaagac atgaccacct tctctgccac ttgggttttc
      721 attgtgacct gggaggaagt cacgttttac ggaggcagca gtaccacacc tgtgaacacc
      781 ttccaggccg tgctggtgtc agatggctcc tacacgttca cactctttaa ttactatgag
      841 atcaactgga ctactgggac agccagtggt ggcgaccctc tgacaggcct cggaggtgtg
      901 atggcacagg caggatttaa tggtggaaac ctcacaaatt tcttcagtct tccggggtcg
      961 agaacccctg agattgtgaa tattcaagag accacaaatg tcaacgttcc aggacgctgg
     1021 gcttttaaag ttgacgggaa ggaaattgac ccggccaatg gctgcacctc tagaggacag
     1081 ttccttcgtc gaggggaggt gttttgggac gacctgaatt gtaccatcaa gtgccgctgt
     1141 ctggatttca acaatgagat ctactgtcag gaggcctcct gtagccccta cgaggtgtgc
     1201 gaacccaagg gccggttctt ctactgcagc ccagtggaga ccagtacctg tgtggtgttt
     1261 ggggaaccac actaccacac ctttgatggc ttcctcttcc acttccaagg ctcttgtgct
     1321 tacctgttgg cccgacagtg tctacaaacc tccagtctcc ccttcttcag tgtggaggcc
     1381 aagaatgagc accgaggagg ctctgctgtc tcatgggtga aggagctctc tgttgaggtg
     1441 aatggctaca agattctcat tcctaaagga agctatggga aagtcaaggt taatgaccta
     1501 gtgacttctt tgcccgtcac cttagagttg ggggcggtga aaatctacca gagtggcatg
     1561 tctactgccg tggaaacaga ttttgggctc ttagtgacgt ttgacggcca gcactacgcc
     1621 tccatttcca tcccaggctc ttacataaac tccacctgtg gactgtgtgg gaactacaac
     1681 aaaaacccac tggacgactt cctccgccca gatggcaggc ccgccatgtc cgtgctggac
     1741 ctcggagaga gttggcgtgt ctaccacact gactggaagt gtggctctgg ctgcatagac
     1801 aactgtactc agtgcgatgc ggccaccgag gccctctact ttggttctga ctactgcggc
     1861 tttctcaaca agacggacgg ccccctgtgg gagtgcggca ctgttgtgga tgccacggct
     1921 ttcgtgcaca gctgtgtgta cgatctgtgc agtgtgaggg acaacggcac gctcctctgc
     1981 caagccattc aggcctacgc cttggtgtgc caagccctgg gcatcccaat cggagactgg
     2041 agaatccaaa ctgggtgtgt gtctaccgtg cggtgcccca gcttcagcca ttactctgta
     2101 tgcaccagta gttgccctga cacctgctcg gacctgacgg cctctcagaa ttgcgccacg
     2161 ccgtgcacgg agggttgcga gtgcaacgag ggttttgtcc tcagtaccag ccagtgtgtc
     2221 ccattgcaca agtgcggctg tgacttcgag ggccactact ataccatggg ggagttcttc
     2281 tgggccacgg ccaattgcac agtgcagtgc ttatgtgaag agggcgggga tgtctactgc
     2341 ttcaacaaga cctgccgcag tggggaggtg tgtgcggtgg aggatggtta ccagggctgc
     2401 ttccccaagc gggagactgt gtgcctgctc agccagaacc aggtgctaca cacgtttgac
     2461 ggcgccgctt acgccttccc atctgagtta tcatacacac tactcaagac ctgccccgag
     2521 cgtcccgagt acttggagat tgacatcaac aagaggaagc ctgatgcagg gcctgcttgg
     2581 ctccggggtg ttcggatcct cgtggctgac caagaggtca agataggagg cgtcggggct
     2641 ttggaagtca agttaaatgg tcaagatgtg gaactaccct ttttccatcc ttcggggagg
     2701 ctggagattc atcgaaacaa aaacagcaca actgtggagt ccaagggtgt ggtgtctgtc
     2761 cagtactctg atgtgggact actctatatc cggctctcca ccatgtactt caactgtact
     2821 gggggcctgt gtggcttctt caacgccaat gccagcgatg agttctgcct tcctaatggc
     2881 aagtgcacag acaacctggc ggtgttcttg gagagttgga ccacgttcga ggaaatctgc
     2941 aacggcgagt gtggggacct gctgaaggcc tgcaacaatg actccgagct gctcaagttc
     3001 tatcggagcc gctcccggtg cggtatcatc aatgacccct ctaatagctc cttcctggag
     3061 tgtcatgggg tggtcaacgt cactgcctac taccgcacct gccttttccg cctatgccag
     3121 agcggaggca acgagtcaga gctgtgcgat tctgtggccc gctatgccag tgcttgcaag
     3181 aacgcagatg tggaggtggg cccctggagg acctatgact tctgccctct cgaatgcccg
     3241 gagaacagcc atttcgagga atgtatgaca tgtacagaga cctgtgagac cttggccttg
     3301 ggccccatct gtgtggatag ctgctctgag ggatgccagt gtgatgaagg ttatgcactg
     3361 cagggcagcc agtgtgtaac tcggagcgag tgcggctgca actttgaggg gcatcaactt
     3421 gccaccaatg agaccttctg ggtagaccag gactgccaga tcttctgcta ctgcaatggc
     3481 acagacaaca gtgtccactg tgagaccatt ccctgcaggg acgatgatta ctgtatggaa
     3541 gagagtggct tatactactg ccagccccgt actgatgctt cctgtatcgt ctccggctat
     3601 ggccactacc tcacttttga tggctaccct tttgacttcc agaccagttg ccctctcatt
     3661 ctctgcacca caggaagcag atcaatctca gactctttcc caaagttcat tgtcacagcc
     3721 aagaatgagg accgggaccc atctctagcc ttgtgggtga agcaggtgga tgtgaccgtg
     3781 tttggctaca gcattgtgat ccaccgggct tacaagcaca ctgtgctggt caacaatgaa
     3841 cggttgtacc tgcccctgaa gttaggacaa gggaagatca acatcttttc cttcggtttt
     3901 catgtggttg tggagacgga ctttggcctg aaggttgtgt atgactggaa aactttcctg
     3961 tctatcaccg tcccccggag catgcagaac agcacttacg gtctttgtgg gcgctacaat
     4021 ggtaaccctg gtgatgacct ggagatgccc atgggcttgc ttgcactgag tatcaatgag
     4081 tttggccaga gctgggtgaa gagggacacc ttctgccagg tgggctgtgg ggaccgctgc
     4141 ccatcgtgtg ccaaagttga aggtttctcc aaagtacagc agctgtgcag cctgatcccc
     4201 aaccagaacg ctgggtttgc caagtgtcac agcaaagtca accctacctt cttctacaaa
     4261 aactgcctct ttgactcctg catcgatggg ggtgcagtgc agacagcctg cagctggtta
     4321 cagaactatg ccagcacttg ccagacacaa ggagtcgcag tgaccggctg gaggaactac
     4381 acatcgtgct cggtcacctg cccccccaac agccactacg agagttgcgt gagcgtctgc
     4441 cagcctcgct gcgctgccat ccgcctgaag agtgactgca atcactactg cgtagagggc
     4501 tgccagtgcg acgcgggcta cgtcctcaac ggcaagagct gcatcttgcc ccacaactgt
     4561 ggctgctact cggacggcaa atactacgag cccaagcagc tattctggaa cggggactgc
     4621 acacggcgct gccgctgttt ccgacgcaac ctgatccagt gcgacccacg ccaatgcaag
     4681 tcagatgaag agtgcgccct gcgcagtggg gtgcgcggct gcttcagcac caagacctcc
     4741 tactgcctgg cggcaggggg cggtgtcttc cgcacgtttg atggcgcctt cctgcgcttc
     4801 cctgccaact gcgccttcgt gctctcgacc atctgccaga aactgccaga catctccttc
     4861 cagctcatca tcaacttcga caagtggtcc tcacccaacc tcactatcat ctcaccggtc
     4921 tatttctaca ttaatgaaga gcagattctc atcaatgacc ggaacactgt caaggtgaat
     4981 ggcacacaag taaatgttcc atttataact ggcttggcaa ccaaaatcta cagcagcgag
     5041 gggtttctgg tgatcgacac cagccctgac atccagatat actacaacgg tttcaacgtc
     5101 attaaaatca gcatcagtga gaggctgcag aacaaagtgt gcggcctctg tggcaacttc
     5161 aatggagaca tgactgatga ctacgtgacc ttgcggggga aacccgtggt gagcagtgtg
     5221 gtgctggccc agagctggaa gaccaatggc atgcagaaga gacctctcac ccccagctgc
     5281 aacgagctac agttctcgca atacgcagcc acgtgtgaca atgtgcacat ccaggccatg
     5341 cagggtgacg gttactgcct gaagctcacc gacatgaagg gcttctttca gccctgctat
     5401 gggctcctgg atcccctccc cttctacgag tcctgctacc tggacggctg ctacaaccac
     5461 aagaagttcc agctgtgcgg ctccctggct gcctacgggg aggcctgccg ttccttcggc
     5521 atccttagca cggagtggat tgagaaagag aattgctcag gagtggttga agacccctgt
     5581 gtgggggcag actgtcccaa caggacctgc gagctggaca acggaggaga attatgtggc
     5641 tgcattgagc caccccccta tggaaacaat tcccatgaca tcatcgacgc agaggtgacc
     5701 tgcaaggcag cccaaatgga agtgtccata tctaaatgca agctctttca gctgggcttt
     5761 gagagagagg gggtgagaat caatgacaga cagtgctctg gcatcgaggg agaggatttt
     5821 atctcctttc agatcaacaa caccaagggg aactgtggga acgtcgtgca gtccaatggt
     5881 actcatatca tgtataaaaa cacaatctgg atcgaaagtg ccaacaacac aggcaacatc
     5941 atcacgaggg accgcaccat caatgtggaa ttttcatgcg cgtatgagct agatatcaag
     6001 atctccttgg actctgttgt gaagcctatg ctaagtgtca tcaacctgac agttccaacc
     6061 caagagggca gcttcaccac caagatggcg ctctataaaa acgcgtccta caaacaccct
     6121 taccgccagg gggaggtcgt gctgacgacc cgggatgtgc tctacgtggg ggtctttgtg
     6181 gttggcgctg actccacaca cttgattctc acactcaaca aatgctacgc caccccgtcc
     6241 cgcgacagca acgacaaact ccggtacttc atcatcgaag gagggtgtca gaacatcaag
     6301 gataacacca ttggcatcga ggagaacgga gtgtccctaa cctgtcgttt ccacgtcacc
     6361 gtcttcaaat tcatcggaga ctacgatgaa gttcatcttc actgtgcagt gtccctctgt
     6421 gactcagaga aatactcttg caagattaat tgcccacaaa attccaggat cgccacagat
     6481 tattcaaaag agcacaaaga acagatcatt tcagtgggac ccattaggag aaagaggctg
     6541 gattggtgtg aagacaatgg cggctgtgag caggtctgca ccagcagggt cgacgggcct
     6601 ctgtgcagtt gcgtgactgg atccctgcaa gaagacggac ggagctgcag agcctctaat
     6661 tcttcagtgg aacctcaagt gtggaccctt cttctcatca tgacccagat ctccctgtgg
     6721 cattttgtct atcaatcagg cgcaacctca taatgaactc agggtgcttc cttcagtccc
     6781 tgtaggtata aaagtgtgtg cccccaagtc aaaacaacct ctcaaactca cgccaccttc
     6841 ctccagctgt cagatccgga ggacaccagc gttcccggct cctcttccac accatgcaat
     6901 agtagcttct caaagccaac aggaggaaag cacgcgttta cctgaatgcc gaagctggca
     6961 ctgggaacct cggtgcaggc cataagccag tcagggacag ctctgctctc agaagtctga
     7021 tgggaaatct ggccggaaaa gtcggtctgt cccgtgctct ttcaggatcg ccgtggttac
     7081 agacaaggct gttgccgtga tttccaataa agctgccgtt ctctctgcgg agcctctccg
     7141 gcactgccct tagcccatgc ttagctcctt ccctcctgct ctggcctcca ccttgccgtg
     7201 ccagcttcgg ccactggaga tgatgattgc agacctggag aacctcaccc agcccttcct
     7261 gaccctcaaa cccagtcctt cactttttac aaatcaacca aataattttt aacgtgtttt
     7321 atccttaaat aaactttgtg ttcaagta
//
LOCUS       NM_053412               3499 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 12, mRNA.
ACCESSION   NM_053412
VERSION     NM_053412.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3499)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3499)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3499)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3499)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3499)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3499)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3499)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced NM_053412.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000008.1  28209003-28209099
            98-195              JAXUCZ010000008.1  28219161-28219258
            196-234             JAXUCZ010000008.1  28219581-28219619
            235-464             JAXUCZ010000008.1  28220002-28220231
            465-642             JAXUCZ010000008.1  28220683-28220860
            643-790             JAXUCZ010000008.1  28223540-28223687
            791-882             JAXUCZ010000008.1  28224972-28225063
            883-978             JAXUCZ010000008.1  28225440-28225535
            979-1090            JAXUCZ010000008.1  28226074-28226185
            1091-1188           JAXUCZ010000008.1  28226611-28226708
            1189-1300           JAXUCZ010000008.1  28227262-28227373
            1301-1411           JAXUCZ010000008.1  28227460-28227570
            1412-1611           JAXUCZ010000008.1  28228703-28228902
            1612-1779           JAXUCZ010000008.1  28229217-28229384
            1780-1905           JAXUCZ010000008.1  28230380-28230505
            1906-2082           JAXUCZ010000008.1  28230664-28230840
            2083-2239           JAXUCZ010000008.1  28230937-28231093
            2240-2293           JAXUCZ010000008.1  28231210-28231263
            2294-2659           JAXUCZ010000008.1  28234392-28234757
            2660-2788           JAXUCZ010000008.1  28235346-28235474
            2789-3499           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3499
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..97
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..195
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             193..2925
                     /gene="Ilf3"
                     /note="isoform 1 is encoded by transcript variant 12; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 1"
                     /protein_id="NP_445864.2"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRRPMRIFVNDDRHVMAKHSSVYPTQEELEAV
                     QNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTL
                     RGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEIL
                     QSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLA
                     ALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTAN
                     RPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHA
                     LRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGE
                     EKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVE
                     VDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAP
                     PPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDK
                     RFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGG
                     PKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNA
                     GAGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPV
                     PPKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSY
                     SSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSG
                     GSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     misc_feature    493..1257
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    493..1257
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1423..1641
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1423..1641
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1438..1440,1447..1452,1459..1464,1468..1470,
                     1510..1515,1519..1521,1525..1527,1576..1584,1591..1593)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1438..1440,1447..1452,1459..1464,1468..1470,
                     1510..1515,1519..1521,1525..1527,1576..1584,1591..1593)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1789..2004
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1789..2004
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1810..1812,1816..1821,1828..1830,1867..1869,
                     1876..1884,1894..1896,1942..1953)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1810..1812,1816..1821,1828..1830,1867..1869,
                     1876..1884,1894..1896,1942..1953)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            196..234
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..464
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..642
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..790
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..882
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..978
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1090
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1188
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1300
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1411
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1611
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1779
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1905
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2082
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2239
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2293
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2659
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2788
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3499
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaacagaa gagggtgtcg gccttcttgg gacagatgat tgtaagctgc atgtgggtgc
       61 caggaactga accctggttc ctctgcaaga gcagtaaata gttgaagtat tggtaacacc
      121 aaggaactgt cacaatttga aaagataagc caaggctgat ttccagacac tacaggaaaa
      181 aaggagggga aaatggcatt gtatcatcat cacttcatca caagaagaag aaggcgtccc
      241 atgagaattt ttgtgaatga tgatcgccat gtgatggcaa agcattcttc agtataccca
      301 acacaagagg agctggaggc tgtacagaac atggtgtccc acactgagcg ggccctcaag
      361 gctgtctctg actggattga tgagcaggag aaaggcaaca gcgagctctc tgaagcagaa
      421 aatatggaca cacccccaga tgatgagagc aaagaagggg ctggggaaca gaaggcggaa
      481 cacatgacta ggaccctgag gggcgtgatg cgggtcggcc tggtagccaa gggtcttctg
      541 ctcaaggggg acttggatct ggagctggtt ctgctctgta aggagaagcc cacaactgcc
      601 cttctggaca aggtggctga caacctggcc atccagctta ctactgtaac agaagacaag
      661 tatgaaatac tccaatctgt ggatgatgct gcgattgtga taaaaaacac aaaagagccc
      721 cccttgtcct tgaccatcca tctgacctcc cctgttgtca gagaagaaat ggagaaagta
      781 ttagctggag aaacgctatc agtcaacgac cccccggacg ttctggacag gcagaaatgc
      841 cttgctgcct tggcgtccct ccgacacgcc aagtggttcc aggctagagc caatgggctg
      901 aagtcatgtg tcattgtcat ccgtgtccta agggacttgt gtacccgagt gcccacctgg
      961 ggtcctctca gaggatggcc tctggagctg ctgtgtgaga agtccatcgg cactgccaat
     1021 aggccaatgg gtgctggtga agccctgcgg agagtactgg agtgcctggc ttccggcatc
     1081 gtaatgccag atggttctgg catttatgac ccttgtgaaa aagaagccac tgatgctatt
     1141 gggcatctag acagacagca acgggaagat atcacacaga gtgcgcagca tgctctgcgg
     1201 cttgctgcct ttggccagct ccataaagta ctgggaatgg acccactgcc ttccaaaatg
     1261 cccaagaaac caaagaacga gaacccggtg gactatactg ttcaaatccc ccccagcacc
     1321 acctacgcca tcacacccat gaaacgccct atggaagaag atggggagga gaagtctccc
     1381 agcaaaaaga aaaagaagat ccagaagaaa gaggagaagg ctgagcctcc ccaagctatg
     1441 aatgccctga tgaggttaaa ccagctgaag ccagggctac agtacaagct gatctcccag
     1501 acgggtcctg ttcacgctcc catcttcacc atgtctgtgg aggtagacgg cagtaccttt
     1561 gaggcctcag ggccatctaa aaagaccgcc aagctacatg tggctgtgaa ggtgttacag
     1621 gacatgggat tgccaacagg cgctgaaggc agagactcca gcaaggggga ggactctgct
     1681 gaggagtcag atgggaagcc agcagtagtg gccccacccc ctgtggtgga agcagtctcc
     1741 aaccccagtt ctgtcttccc ttcagatgcc actactgagc aggggccgat tttgactaag
     1801 cacggcaaga atcctgtaat ggagcttaat gagaagagac gtggcctcaa atatgagctc
     1861 atttctgaga cagggggcag ccacgacaaa cggtttgtta tggaggttga ggtggacgga
     1921 cagaagtttc aaggtgctgg ctcaaacaaa aaggtagcaa aggcttatgc tgcacttgcc
     1981 gcattagaga agcttttccc tgacgcccct cttgctcttg aagccaacaa gaagaaaaga
     2041 gcccctgtgc ctgtccgagg cggacccaaa tttgctgcca agccacataa ccctggcttt
     2101 ggcatgggag gccccatgca taatgaagcg cccccacctc ccaacatccg aggtcggggc
     2161 cgaggaggta acatccgagg gcgaggacgg gggcgaggat ttggtggcac caaccacgga
     2221 ggaggctaca tgaatgctgg cgctggatat ggaagctatg ggtacagcag caattcggcc
     2281 acagcaggct acagtcagtt ctacagcaat ggagggcatt ctgggaatgc cggtggtgga
     2341 ggcagcgggg gaggtggtgg ctcgtccagc tacagctcct actaccaagg agacagctac
     2401 aactcaccag tgcccccgaa acatgctggg aagaagccgc tgcatggggg ccagcagaaa
     2461 ccctcctaca gctcgggcta ccagtcccac cagggccagc agcaacctta caaccagagc
     2521 cagtacagca gctacggcac gccacagggc aagcagaaag gctatggcca tgggcagggc
     2581 agctactcct cctactccaa ctcttacaac tcccctggtg gtggtggggg ctctgactac
     2641 agctacgaca gcaaattcaa ctacagtggt agtggaggcc ggagtggagg gaacagctat
     2701 ggctccagcg ggtcatccta caacacaggc tcacatgggg gttatggcgc aggttctgga
     2761 ggcagctctt cataccaagg caaacaagga ggctactcat cacagtcaaa ctacagctcc
     2821 cctgggtcca gccagagcta cagcggcccc gccagctcct accagtcctc acagggtggc
     2881 tacagtcgga acacagaaca cagcatgaac taccagtaca gataaaggcc caggctgccc
     2941 ctctcaacct tctgcacctc tgcctccaac ttgtctcggg agattgagtc tgcacatcac
     3001 cagttgccat gtccactggg ccagtgccca cccgtccacg ttgctgacgt tgccacgctg
     3061 tgaggcgtgg tggtccctgg gacccgtgct gtgaccctat ttagctgtgt tttggactca
     3121 gtgtcttcag tggtttgtta gttaccatta caccttgtct gagtagtgtt ccgagttctt
     3181 gccgtgcgga atccctctgt ctgtttatgc ccggtgtgag ttccatcggg tgtctttaaa
     3241 tagttgcaga agggatacgt catctgttaa tgctttttgt gaagtgagtt aaatgagctt
     3301 tcattatttt aatgcttagt gtttcagttt tataagtgaa aattttattt taaaaaacag
     3361 tggggtttgt ttttttgttt ttttgtcttt gtttttgttt tttttttttt tttttttttt
     3421 ttttttggta tgtctggatc attcaggcag tacatttgaa ttccgctgaa tgtagataaa
     3481 taaaagaaaa acaaaacag
//
LOCUS       NM_001106803             885 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 3-like 1
            (Mbd3l1), transcript variant 4, mRNA.
ACCESSION   NM_001106803 XM_001075394 XM_235884
VERSION     NM_001106803.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 885)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced NM_001106803.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000008.1  24432245-24432336
            93-151              JAXUCZ010000008.1  24433065-24433123
            152-885             JAXUCZ010000008.1  24435954-24436687
FEATURES             Location/Qualifiers
     source          1..885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..885
                     /gene="Mbd3l1"
                     /note="methyl-CpG binding domain protein 3-like 1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
     exon            1..92
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..151
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..885
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Mbd3l1"
                     /note="upstream in-frame stop codon"
     CDS             170..730
                     /gene="Mbd3l1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3-like 1"
                     /protein_id="NP_001100273.1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
                     /translation="MGKTSQRKQCDCENPSKPCLSTSIPLRMSNYTFKRPVTKITSHL
                     GNEVRYYQWEETLEKPEQACWQKRLQGLQAYSSAGEILSTSDLSKALKDLTPRDTDAA
                     SSIIQANSMDPRPLSTLGSSSHLAKMIPEAGPQILCKEFLVTEEDISIQERKVKIARE
                     RLAVALIAHKLANETEKVRGSRKAKV"
     misc_feature    194..391
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    194..391
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    401..667
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
     misc_feature    401..667
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
ORIGIN      
        1 gacaacatat gaaggttcta aatcatccag agagctggtt agaggtaaga ggtaagatgt
       61 tacagagaaa tgtaatacag agctggttgg agactggcaa tagctgcggc atgatattga
      121 tggcagtctt ccagatatga agttttaaaa aggctaagaa cggagtcaga tgggcaagac
      181 ttcacagagg aagcaatgtg actgtgagaa tccatcaaag ccttgtttaa gtacctcaat
      241 ccccctgagg atgtctaatt atacattcaa gaggccagtc actaaaatca catcccatct
      301 gggcaatgag gtaagatact atcagtggga ggagaccttg gagaagccgg agcaagcctg
      361 ctggcaaaag agacttcaag gactccaggc ctacagcagt gcgggagaaa ttttgagcac
      421 ttcagacctt tccaaggctt tgaaagatct tacacctaga gacacagacg ccgcctcttc
      481 aatcattcaa gctaacagca tggaccccag gcccttgtcc acccttgggt catcttcaca
      541 tttggcaaag atgataccag aagcaggccc acagatcctt tgcaaagaat ttctggtcac
      601 tgaagaggat attagcatcc aggaaaggaa agtgaaaata gcaagagaaa gactggcagt
      661 ggcattgatt gcacacaagc tagcaaatga gacagagaaa gtgaggggtt caaggaaagc
      721 aaaggtataa acatgatggg gggagggagt actggggaaa agacactgca cgtgaaatgg
      781 ggcatagcct tgttttaacg cctctttgca gtctttagtt gttttgagac cttgaaactt
      841 taaacttaac aatactttat taaaagtctg tgcgatgcaa aaaaa
//
LOCUS       NM_001436445            1896 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 5, mRNA.
ACCESSION   NM_001436445 XM_006243700
VERSION     NM_001436445.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006243700.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061732.1, CF111044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  117870535-117870689
            156-234             JAXUCZ010000008.1  117880565-117880643
            235-392             JAXUCZ010000008.1  117894634-117894791
            393-513             JAXUCZ010000008.1  117897631-117897751
            514-644             JAXUCZ010000008.1  117901968-117902098
            645-1896            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1896
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..155
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..234
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            235..392
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..818
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423374.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     237..806
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    249..773
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    249..773
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(249..251,336..338,345..350,357..359,363..365,
                     369..371,396..398,408..413,417..425,432..434,438..440,
                     450..452)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(249..251,336..338,345..350,357..359,363..365,
                     369..371,396..398,408..413,417..425,432..434,438..440,
                     450..452)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    270..293
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    270..293
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(279..296,336..341,345..347,411..416,588..590,
                     594..596,717..722)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(279..296,336..341,345..347,411..416,588..590,
                     594..596,717..722)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(303..305,309..323,360..365,369..377,390..398,
                     723..728,738..743,750..752)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(303..305,309..323,360..365,369..377,390..398,
                     723..728,738..743,750..752)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(336..338,342..344,348..353,423..434,441..443,
                     450..452,516..518)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(336..338,342..344,348..353,423..434,441..443,
                     450..452,516..518)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    336..362
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    336..362
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    336..362
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(345..350,417..419,432..434,438..443,447..452,
                     459..461,549..554,558..560)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(345..350,417..419,432..434,438..443,447..452,
                     459..461,549..554,558..560)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    345..347
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    345..347
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(351..353,429..443,450..452,525..527,537..539,
                     549..551)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(351..353,429..443,450..452,525..527,537..539,
                     549..551)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(351..356,429..434,438..443,450..452)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(351..356,429..434,438..443,450..452)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    411..422
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    411..422
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    417..470
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    420..473
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    420..473
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    585..596
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    585..596
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    714..722
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    714..722
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    798..800
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    804..806
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            393..513
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..644
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1896
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgcgctc cccgcccgcc gcccgcggtc ctccgtcggt tctctcctta gcccgccgtc
       61 tcccacggag ctgctcgccc ttgtctcgga gctcgcggac tcgcggacag gcgtcctcag
      121 cgcgaagagg ccggattcgg agtcgtcgtc ttgagccttg catctaagaa gtcccaggta
      181 ctttgtacaa ctgcatccca gaagctgagt ttcttcagca ccttcataag gtattgatgg
      241 ctgccatcag gaagaaactg gtgattgttg gtgatggagc ttgtggtaag acatgcttgc
      301 tcatagtctt cagcaaggac cagttcccag aggtttatgt gcccacggtg tttgaaaact
      361 atgtggcaga tattgaagtg gacgggaagc aggtagagtt ggctttatgg gacacagctg
      421 gacaggaaga ttatgaccgt ctgaggcctc tctcctaccc agacactgat gttatactga
      481 tgtgtttttc catcgacagc cctgatagtt tagaaaacat cccagaaaaa tggactccag
      541 aagtcaagca tttctgtcca aatgtgccca tcatcctagt tgggaacaag aaggatcttc
      601 ggaatgatga gcacacaagg cgggagttag ccaaaatgaa gcaggagccg gtaaaacctg
      661 aagaaggcag agatatggca aacaggattg gcgcttttgg gtacatggag tgttcagcaa
      721 agaccaaaga cggagtgaga gaggtttttg agatggccac gagagctgct ctgcaagcta
      781 gacgcgggaa gaaaaagtcg gggtgcctca tcttgtgaag ccttgtgacg cgcagcctca
      841 tgcggttaat ttgaagtgct gtttattaat cttagtgtat gattactggc cttttcattt
      901 atctataatt tacctaagat tacaaatcag aagtcatctt gctaccagta tttagaagcc
      961 aaccatgatt attaatgatg tccagcctgt ctgaccagcc agggtccttc tgacactgct
     1021 ctaacgccct ctctgcactc cacctgacac caggcgctca ttcaaagaat ttcttaactt
     1081 cctgcttctt tctagaaaga gaaacagttg gtaacttttg tgaattaggc tgtaactact
     1141 ttataactaa catgtcctgc ctattttctg tcagctgcga ggaactctgg tgagtcacta
     1201 cttcagagct ttactcctta acagattcca ttggcagagc tctggggtgg gcacccagtg
     1261 tttggaaact tgatcagcca gaaaggccca agtccacgca gctgtggcag agttacagtt
     1321 ctgtggtctc atgttagtta ccttatagtt actgtgtaat tagtgccact taatgtatgt
     1381 taccaaaaat aaatatatct accccagact agatgtagta ttttttgtat aattggattt
     1441 cctaattctg atatttgtca ttcccacaga aagtgtattg cttttttttt tttttaagaa
     1501 agtatttgga aataaagtca gatggaaaat tcatttttaa aattcccatt ttgtcacttt
     1561 ctctgataaa atatggccat atctccccta tttagcccta tatatcattc cagtgcccct
     1621 ttccagactg gactgaggaa ataggaattg gtttcatgcc tgaggctgtt agactttgga
     1681 ggtggcatag cctttctcac ctggactgca gggcctggct ctaagtcaca gtgctccttt
     1741 ctccacactg ttatccaagt cgcctcccag aggagccacc agttcttatg ggtggcaatg
     1801 ggtgggtggg tggggggtct cctctctcca gctgactaaa cttttttctg taccagttaa
     1861 tttttccaac taatagaata aaggcagttt tctaaa
//
LOCUS       NM_001436460            2558 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 49 (Lrrc49),
            transcript variant 4, mRNA.
ACCESSION   NM_001436460 XM_063265146
VERSION     NM_001436460.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2558)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063265146.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.883958.1,
                                           SRR26643298.44687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000008.1  70055852-70055951   c
            101-157             JAXUCZ010000008.1  70055581-70055637   c
            158-245             JAXUCZ010000008.1  70053406-70053493   c
            246-348             JAXUCZ010000008.1  70048576-70048678   c
            349-552             JAXUCZ010000008.1  70045578-70045781   c
            553-619             JAXUCZ010000008.1  70039865-70039931   c
            620-763             JAXUCZ010000008.1  70037281-70037424   c
            764-825             JAXUCZ010000008.1  70019484-70019545   c
            826-973             JAXUCZ010000008.1  69996747-69996894   c
            974-1057            JAXUCZ010000008.1  69984849-69984932   c
            1058-1221           JAXUCZ010000008.1  69980873-69981036   c
            1222-1459           JAXUCZ010000008.1  69965190-69965427   c
            1460-1645           JAXUCZ010000008.1  69963925-69964110   c
            1646-1755           JAXUCZ010000008.1  69959742-69959851   c
            1756-1909           JAXUCZ010000008.1  69954547-69954700   c
            1910-2558           JAXUCZ010000008.1  69948964-69949612   c
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2558
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     exon            1..100
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="upstream in-frame stop codon"
     CDS             71..2113
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="isoform 4 is encoded by transcript variant 4;
                     leucine-rich repeat-containing protein 49"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 49
                     isoform 4"
                     /protein_id="NP_001423389.1"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
                     /translation="MSGLQSLRYKVNCGLHLVIQTSSLSDKNKVEFKLNRETPSFPGR
                     LLQHDLERNYSSRQGDHINLVSSSMPSFPILQRSSEEKTLYSDRLTLERQKLTVCPII
                     DGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKN
                     RIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSL
                     TELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIA
                     QESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVAKKEEEKKRESHKQSLLKEKKRL
                     TINNVARKWDLQQRVANIAIIQDRKDSESPPQESCQIDGGTISAFPEEAGSLDAGLSS
                     ALQGLSVTETHLVELDGETLSLYGSGALECLDRNWSVQTAGMVTTVSFTFIEFDEIVQ
                     VLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNFTLWKYY
                     VLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRMISILGDARKKQF
                     RYLLENKCKKPGILCEETSDSKRLMGENTNRATLNYTTREFYHEKLEEIKDKKKFCRL
                     YVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSYMKLCLQQITDQK"
     misc_feature    332..385
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    332..385
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    392..457
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    392..457
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    401..988
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    401..988
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    458..523
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    458..523
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    524..589
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    524..589
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    590..655
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    590..655
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    656..721
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    656..721
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    722..787
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    722..787
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    788..862
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    788..862
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            101..157
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            158..245
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            246..348
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            349..552
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            553..619
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            620..763
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            764..825
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            826..973
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1057
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1221
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1459
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1645
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1755
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1909
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2558
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaggaac ctgttcttag acactcccac ctcctttatt caaacactga tatactgact
       61 ggcaagagaa atgtcagggc tccaaagcct gaggtacaag gtgaactgtg gacttcatct
      121 ggttattcaa acgtcgtcac tttctgacaa aaacaaagtt gaattcaagc ttaatagaga
      181 aacaccatca tttcctggta gactgttaca gcatgacctg gagagaaact actcaagtag
      241 acaaggtgat cacattaatc tggtgagctc atcaatgcca tcatttccta ttctccagcg
      301 ttcttctgaa gagaaaactc tttactcaga caggctgacc ctagaaagac aaaagttgac
      361 tgtgtgccct atcatcgacg gggaggagca ccttcgtttg ttgaactttc agcacaattt
      421 tataactcgg atccaaaata tttctaatct acagaggcta atattcttgg acttatatga
      481 taaccagatt gaagaaatta gtgggctttc cactctgaaa tcccttcgtg tcctcctgtt
      541 agggaagaac agaatcaaga aaatctcaaa tctggagaat ctaaaaaatt tagatgtctt
      601 ggaccttcat ggaaatcaga ttaccaaaat tgaaaatgtt aatcatttgt gtgacttgag
      661 agttttaaac cttgccagga acctcttgag tcatgttgac aatctcaacg gtctggattc
      721 actaacagaa cttaaccttc gccacaacca gatcaccttc gtgagagatg tggataattt
      781 gccctgcctc caacgcctct tcctcagctt caacaatata actagctttg aaagtgtttc
      841 ctgccttgct gagtcaactt ccctctcaga catcaccttt gatggcaatc caatagctca
      901 agagtcatgg tacaaacaca cggtccttca gaatatgatg cagctgcgcc agctagacat
      961 gaagagaatc acggaagaag aaagacgcgt ggcatctgtt gtggccaaaa aagaggagga
     1021 gaagaagagg gagagtcaca agcagtcctt gctgaaggag aagaaaaggt taacaattaa
     1081 caacgtcgct cgaaagtggg acttgcagca acgagtagcc aatatcgcca tcattcagga
     1141 cagaaaggac tctgagtctc ctcctcagga atcctgtcag atcgatggag gcaccatctc
     1201 cgcatttccc gaggaagcag ggtctctaga tgcgggactc agcagtgcgt tacaaggctt
     1261 gtctgtcaca gaaacacact tggtggagct agatggagaa accctgtcac tgtatggctc
     1321 aggggcgctg gaatgcctag atcgtaactg gagtgttcaa acagctggca tggtcaccac
     1381 cgtctcgttc acattcatcg agtttgatga aattgtccaa gtacttccca aactgaagat
     1441 gaagtttcca aattctctgc accttaagtt cagggagacc aaccttgtga tgctgcagca
     1501 gttcaacgcc ctcgcgcaac ttcgtcgggt tgaccagttg acaatcgatc ctcagggaaa
     1561 cccagtggtg aacttcacac tctggaagta ctacgtgctg tttaggctca gccacttcag
     1621 catgcagaaa ataaatggaa cagaggtgac acaaaatgac atgataatgg ctgaaaggct
     1681 ctttggaatc ttagcacatg tggcatcctc tgagctgccc cagtaccgca tgatttcaat
     1741 tctgggtgat gccaggaaaa agcagttccg gtatctgctg gagaacaaat gtaaaaagcc
     1801 tggcatcctc tgtgaggaga cgagtgacag caagagatta atgggggaaa acacaaaccg
     1861 agctaccctg aattacacca cccgagaatt ctaccacgag aagctggagg aaataaagga
     1921 caagaagaag ttctgcaggt tgtatgtaga agacctggtg aaggaagcca cagccatcaa
     1981 catgaaaaat gaggctctgc agaagctgtg gccacagatg ttcatcgagc ttgtcaggga
     2041 tgccgtcata gagatccgca gcaaggactc ctacatgaag ctctgcctgc agcagatcac
     2101 tgaccagaaa tagggatggc tcatgcttca gacatgggca attggagctg ttttaaagtt
     2161 gggcaagatg caggttagac atgatgagac atcaccactt ccgcacatac tagaaagagc
     2221 ggcatcaaag cctcgccccc tgcactgttg aggaggaggg aggcaggaga gagggggact
     2281 ctttcccacg catgctgacc acacaacctt ggggacccga gcagcaactg gagaaggcct
     2341 ggctgctggg tcagaaatgc ttcttcagct cctgctctga ctggtgtgcc tgcccccgtc
     2401 ccaggcacag tgcgtgctga tgggcaagca tgagacgcct ctaccaacct ccagctgaga
     2461 cttttctctt attttgcctt tttattttat gtcatgattt caaagccaag cttatgttct
     2521 tttttatgag tgaaaaataa atacattagt aaaaaaaa
//
LOCUS       NM_001134469            2693 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 49 (Lrrc49),
            transcript variant 2, mRNA.
ACCESSION   NM_001134469 XM_001073479 XM_236333
VERSION     NM_001134469.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2693)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2693)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced NM_001134469.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160848.1, SRR26360172.1761484.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000008.1  70056247-70056481   c
            236-292             JAXUCZ010000008.1  70055581-70055637   c
            293-380             JAXUCZ010000008.1  70053406-70053493   c
            381-483             JAXUCZ010000008.1  70048576-70048678   c
            484-687             JAXUCZ010000008.1  70045578-70045781   c
            688-754             JAXUCZ010000008.1  70039865-70039931   c
            755-898             JAXUCZ010000008.1  70037281-70037424   c
            899-960             JAXUCZ010000008.1  70019484-70019545   c
            961-1108            JAXUCZ010000008.1  69996747-69996894   c
            1109-1192           JAXUCZ010000008.1  69984849-69984932   c
            1193-1356           JAXUCZ010000008.1  69980873-69981036   c
            1357-1594           JAXUCZ010000008.1  69965190-69965427   c
            1595-1780           JAXUCZ010000008.1  69963925-69964110   c
            1781-1890           JAXUCZ010000008.1  69959742-69959851   c
            1891-2044           JAXUCZ010000008.1  69954547-69954700   c
            2045-2693           JAXUCZ010000008.1  69948964-69949612   c
FEATURES             Location/Qualifiers
     source          1..2693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2693
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     exon            1..235
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="upstream in-frame stop codon"
     CDS             188..2248
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 49"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 49
                     isoform 2"
                     /protein_id="NP_001127941.1"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
                     /translation="MIPGKYRSVSGRAANNVNCGLHLVIQTSSLSDKNKVEFKLNRET
                     PSFPGRLLQHDLERNYSSRQGDHINLVSSSMPSFPILQRSSEEKTLYSDRLTLERQKL
                     TVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRV
                     LLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNL
                     NGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITF
                     DGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVAKKEEEKKRESHKQSLL
                     KEKKRLTINNVARKWDLQQRVANIAIIQDRKDSESPPQESCQIDGGTISAFPEEAGSL
                     DAGLSSALQGLSVTETHLVELDGETLSLYGSGALECLDRNWSVQTAGMVTTVSFTFIE
                     FDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNF
                     TLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRMISILGD
                     ARKKQFRYLLENKCKKPGILCEETSDSKRLMGENTNRATLNYTTREFYHEKLEEIKDK
                     KKFCRLYVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSYMKLCLQQI
                     TDQK"
     misc_feature    467..520
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    467..520
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    527..592
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    527..592
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    536..1123
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    536..1123
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    593..658
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    593..658
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    659..724
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    659..724
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..790
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..790
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    791..856
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    791..856
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    857..922
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    857..922
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    923..997
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    923..997
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            236..292
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            293..380
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            381..483
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            484..687
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            688..754
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            755..898
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            899..960
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1108
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1192
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1356
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1594
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1780
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1890
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2044
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2693
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagataatc cctgaggcta gccacccgga cggcccacag atctggggcg aggaccagac
       61 cggaaatggt ggtttctatg gtaacccctg aacaggttgc ctgggagatg accccttttg
      121 gtctctttga atcttagctg ttgcattacc tcgaaggagg atcgaacatc ctggactgtt
      181 tcctgccatg attcccggga aataccgctc cgtttctggc cgggctgcaa acaacgtgaa
      241 ctgtggactt catctggtta ttcaaacgtc gtcactttct gacaaaaaca aagttgaatt
      301 caagcttaat agagaaacac catcatttcc tggtagactg ttacagcatg acctggagag
      361 aaactactca agtagacaag gtgatcacat taatctggtg agctcatcaa tgccatcatt
      421 tcctattctc cagcgttctt ctgaagagaa aactctttac tcagacaggc tgaccctaga
      481 aagacaaaag ttgactgtgt gccctatcat cgacggggag gagcaccttc gtttgttgaa
      541 ctttcagcac aattttataa ctcggatcca aaatatttct aatctacaga ggctaatatt
      601 cttggactta tatgataacc agattgaaga aattagtggg ctttccactc tgaaatccct
      661 tcgtgtcctc ctgttaggga agaacagaat caagaaaatc tcaaatctgg agaatctaaa
      721 aaatttagat gtcttggacc ttcatggaaa tcagattacc aaaattgaaa atgttaatca
      781 tttgtgtgac ttgagagttt taaaccttgc caggaacctc ttgagtcatg ttgacaatct
      841 caacggtctg gattcactaa cagaacttaa ccttcgccac aaccagatca ccttcgtgag
      901 agatgtggat aatttgccct gcctccaacg cctcttcctc agcttcaaca atataactag
      961 ctttgaaagt gtttcctgcc ttgctgagtc aacttccctc tcagacatca cctttgatgg
     1021 caatccaata gctcaagagt catggtacaa acacacggtc cttcagaata tgatgcagct
     1081 gcgccagcta gacatgaaga gaatcacgga agaagaaaga cgcgtggcat ctgttgtggc
     1141 caaaaaagag gaggagaaga agagggagag tcacaagcag tccttgctga aggagaagaa
     1201 aaggttaaca attaacaacg tcgctcgaaa gtgggacttg cagcaacgag tagccaatat
     1261 cgccatcatt caggacagaa aggactctga gtctcctcct caggaatcct gtcagatcga
     1321 tggaggcacc atctccgcat ttcccgagga agcagggtct ctagatgcgg gactcagcag
     1381 tgcgttacaa ggcttgtctg tcacagaaac acacttggtg gagctagatg gagaaaccct
     1441 gtcactgtat ggctcagggg cgctggaatg cctagatcgt aactggagtg ttcaaacagc
     1501 tggcatggtc accaccgtct cgttcacatt catcgagttt gatgaaattg tccaagtact
     1561 tcccaaactg aagatgaagt ttccaaattc tctgcacctt aagttcaggg agaccaacct
     1621 tgtgatgctg cagcagttca acgccctcgc gcaacttcgt cgggttgacc agttgacaat
     1681 cgatcctcag ggaaacccag tggtgaactt cacactctgg aagtactacg tgctgtttag
     1741 gctcagccac ttcagcatgc agaaaataaa tggaacagag gtgacacaaa atgacatgat
     1801 aatggctgaa aggctctttg gaatcttagc acatgtggca tcctctgagc tgccccagta
     1861 ccgcatgatt tcaattctgg gtgatgccag gaaaaagcag ttccggtatc tgctggagaa
     1921 caaatgtaaa aagcctggca tcctctgtga ggagacgagt gacagcaaga gattaatggg
     1981 ggaaaacaca aaccgagcta ccctgaatta caccacccga gaattctacc acgagaagct
     2041 ggaggaaata aaggacaaga agaagttctg caggttgtat gtagaagacc tggtgaagga
     2101 agccacagcc atcaacatga aaaatgaggc tctgcagaag ctgtggccac agatgttcat
     2161 cgagcttgtc agggatgccg tcatagagat ccgcagcaag gactcctaca tgaagctctg
     2221 cctgcagcag atcactgacc agaaataggg atggctcatg cttcagacat gggcaattgg
     2281 agctgtttta aagttgggca agatgcaggt tagacatgat gagacatcac cacttccgca
     2341 catactagaa agagcggcat caaagcctcg ccccctgcac tgttgaggag gagggaggca
     2401 ggagagaggg ggactctttc ccacgcatgc tgaccacaca accttgggga cccgagcagc
     2461 aactggagaa ggcctggctg ctgggtcaga aatgcttctt cagctcctgc tctgactggt
     2521 gtgcctgccc ccgtcccagg cacagtgcgt gctgatgggc aagcatgaga cgcctctacc
     2581 aacctccagc tgagactttt ctcttatttt gcctttttat tttatgtcat gatttcaaag
     2641 ccaagcttat gttctttttt atgagtgaaa aataaataca ttagtaaaaa aaa
//
LOCUS       NM_001436462            5876 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus BCL2 interacting protein 2 (Bnip2), transcript
            variant 2, mRNA.
ACCESSION   NM_001436462 XM_006243371
VERSION     NM_001436462.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5876)
  AUTHORS   Cho,B., Choi,S.Y., Park,O.H., Sun,W. and Geum,D.
  TITLE     Differential expression of BNIP family members of BH3-only proteins
            during the development and after axotomy in the rat
  JOURNAL   Mol Cells 33 (6), 605-610 (2012)
   PUBMED   22639046
REFERENCE   2  (bases 1 to 5876)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   3  (bases 1 to 5876)
  AUTHORS   Lu,M. and Krauss,R.S.
  TITLE     N-cadherin ligation, but not Sonic hedgehog binding, initiates
            Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4212-4217 (2010)
   PUBMED   20160094
REFERENCE   4  (bases 1 to 5876)
  AUTHORS   Oh,J.E., Bae,G.U., Yang,Y.J., Yi,M.J., Lee,H.J., Kim,B.G.,
            Krauss,R.S. and Kang,J.S.
  TITLE     Cdo promotes neuronal differentiation via activation of the p38
            mitogen-activated protein kinase pathway
  JOURNAL   FASEB J 23 (7), 2088-2099 (2009)
   PUBMED   19244314
REFERENCE   5  (bases 1 to 5876)
  AUTHORS   Sonn,S., Jeong,Y. and Rhee,K.
  TITLE     Nip2/centrobin may be a substrate of Nek2 that is required for
            proper spindle assembly during mitosis in early mouse embryos
  JOURNAL   Mol Reprod Dev 76 (6), 587-592 (2009)
   PUBMED   19117032
REFERENCE   6  (bases 1 to 5876)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006243371.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.34385.1,
                                           SRR26643290.29846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000008.1  79521377-79521565
            190-296             JAXUCZ010000008.1  79526784-79526890
            297-364             JAXUCZ010000008.1  79527506-79527573
            365-541             JAXUCZ010000008.1  79528505-79528681
            542-718             JAXUCZ010000008.1  79530492-79530668
            719-821             JAXUCZ010000008.1  79531627-79531729
            822-953             JAXUCZ010000008.1  79532710-79532841
            954-1040            JAXUCZ010000008.1  79534110-79534196
            1041-1139           JAXUCZ010000008.1  79534300-79534398
            1140-5876           JAXUCZ010000008.1  79537954-79542690
FEATURES             Location/Qualifiers
     source          1..5876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5876
                     /gene="Bnip2"
                     /note="BCL2 interacting protein 2"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
     exon            1..189
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..296
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1191
                     /gene="Bnip2"
                     /note="isoform 2 is encoded by transcript variant 2; Bcl-2
                     and E1B 19 kDa interacting protein; BCL2/adenovirus E1B
                     19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B
                     interacting protein 2; BCL2/adenovirus E1B 19 kDa
                     protein-interacting protein 2"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 2 isoform 2"
                     /protein_id="NP_001423391.1"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
                     /translation="MEGVELKEEWQDEDFPIPLPEDDSIEADILDVTDPDRQPGSLEV
                     NGNKVRKKLVAPDISLTLDPGEDSLWSDDLDEGGEVDLDGLDTPSENSDEFEWEDDLP
                     KPKTTEVIRKGSITEYAATEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYY
                     GDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIIYLNGATTRR
                     KMPSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVF
                     NLAELAELVPMEYVGIPECIKQVDQELNGKQEPPKSEQ"
     misc_feature    391..735
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    391..735
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    685..1131
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     misc_feature    685..1131
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     exon            297..364
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..541
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..718
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..821
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..953
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1040
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1139
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..5876
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgaatccg ggtcagctgc tgcctccggg actgcagctg agaccgtccg ggaaaagctg
       61 ggccccgtct ccacagccga ccaagggcag cgggctctgc ccggcgccac tttctgcgac
      121 ctggccgtca gccccacgtc gccggcctgg aggggcaaag aggacgaggg ggccgcggct
      181 tcctccgggg acctcggctg cctggattgc caggagctgg aagttgacat tgagtctagg
      241 ctgaggatgg aaggtgtgga actgaaagaa gaatggcagg atgaagactt cccaatacct
      301 ttaccagaag atgacagcat tgaagcagat atactagatg taactgatcc agacagacag
      361 cctggctcgt tagaagttaa tggaaacaaa gtacggaaga aactggtggc cccagacatc
      421 agcctgacct tggatcctgg tgaagactct ctgtggtcag atgatttgga tgaaggtgga
      481 gaagttgacc tggatggctt agacaccccc tcagagaaca gtgatgagtt tgagtgggaa
      541 gatgatcttc ccaaacccaa aactactgaa gtcattagga aaggctcaat tactgaatat
      601 gcagctacag aagaaaagga agatggacgc cgctggcgca tgttcaggat tggagagcag
      661 gaccatagag tggacatgaa ggcaatcgaa ccctacaaaa aagttattag ccatggaggc
      721 tattatgggg atggcttaaa tgccattgtt gtatttgctg tctgtttcat gcctgagagt
      781 ggtcagccta actatagata tttgatggac aatctcttta aatatgttat tggcacttta
      841 gagctgttgg tagcagagaa ctacatgatc atttacttaa atggtgcgac aacgcgaagg
      901 aaaatgccca gtctgggatg gctcaggaga tgctaccagc aaatcgacag acgattaagg
      961 aaaaacctaa agtctctaat cattgtgcac ccctcttggt ttatccgaac acttctggct
     1021 gttacaagac catttatcag ttcaaaattc agtcagaaga ttagatacgt ctttaatttg
     1081 gctgaactgg cggagcttgt tcccatggag tacgtcggca taccagagtg catcaaacaa
     1141 gttgatcaag agcttaatgg gaaacaggaa ccaccaaaga gtgagcagta agttccgcat
     1201 ccatcccgga ggaggcagag caccgggggc agggctgtag tgcatcctag tgcactgctg
     1261 gctcaagggt ttatgtcatc tgttacaaaa tttacttgac ttctttccaa atgaactctt
     1321 gtacaaggga ctgttcactg ctgtcatggt ttgcaactgt tgaatttagc tctttaataa
     1381 ctaattatat tgtaatcgtt ttatattgct aaatagcaaa aactacactt tatataaaac
     1441 aatttttaca tttgtttatt tgaaatgatg catcttcagt aaagtattta tatacataaa
     1501 tgacaaagga aagaaataat atatattttt atgtttgggg gcaatatttt ttagtgtgta
     1561 cctatctcgt ggatgaatat gtacaagtaa ataagaccac gattttaagt gtaaagtgca
     1621 tgtaagactt tgtttttgta aatggttgga tacatttcct gggtaactta ggctgggttg
     1681 tcctaaagca ggggcaggta aattgacgcc aagaagtacc taaggtcatg catgtggtct
     1741 gggcagtagc agcagcctga gcttctcctc acctgaaagc acgttgtatc ttaatgtggt
     1801 ggaaaggcag gtgggtgaat gacttgtttt cctctctgaa gacatgttgg aactagaact
     1861 agagattttg aaaagctagt agttagggtt tattatatat ttgtatataa gggacactgt
     1921 actttaccca aagtcagaac tgttctaaga agaaagcaag ctcttaagat gtgttcagtc
     1981 acgtgagctg agtggtgtcg tgtgtgtgaa gctgtgaggt gtgcagaggc ttcgatgagc
     2041 attcatggtc agctgcatct gtagagcaga tggcgctatg gcatgctctc acagtggggc
     2101 actttaccag agtacgtcct cgccggctgt ccgaccacag tggtatttgg cctcagcaga
     2161 tgggcgttct cgctgctgtc ggatggtgtg acagtgctgt ccatgggtca gttctgtaag
     2221 tgctgaggtg ctactgctgt gcacccggga tgccatttgc tgtatgtaag cctttagctc
     2281 atgtggttaa gtaccttgac tgaacgttga aataaatatt atttgtgcct ccaaccaggg
     2341 tctaaaagtc attctaaaac aacagatttg tctagtcttg tgtcatggac ttgcctggtg
     2401 tatgtatgtt tagtgcacta tcagcttcac gacccccagc ccgtcatgta aattgtttac
     2461 agaagtgatc cagcaaaata acattgaaca ggcgtaaact aagcttaggt tatttcctcc
     2521 cacactgagc acatgacctt caccattgca gtttttaggg ttaagcttct attgcaatag
     2581 ggaatttttc tttatttctt tgtccttctt ggacataaat ttgacctact agattaaaac
     2641 cagttatggt caagctggag gactttgtgg ataaaacatt tctccacaac ctcagcctag
     2701 atccaggact cgtgttgttg cagtgcattg agccaaaacc attttgcttg tgttgatgaa
     2761 ggaaactttg agaataacta tataacacca ggcatggtgg catgaattta agggcagcct
     2821 ggcctacata gctgcataga caaccttctg aacttaccca agagtcgcga gtagcttgta
     2881 gatacagtgg cttacagagc ctctcaccta ccttgtctca gaatggactg agctttgtct
     2941 ttggttttct tccacattaa atactaagat catcagtttc aaaatacaga cgatagcctc
     3001 agctttttac tgtgttttac tttttgcaga aatggttggt ttggggtttt ttgtttgttt
     3061 tgggtctttt taaaaattaa aagtagccta tattcagtta gaacatggag agctggctca
     3121 acagttgtaa gaacacttcc aagtttagtt cccagcacca atggccagca gcagctcacg
     3181 gctgccttta attccagctc caggggattt gcttcagtct ctggcctctg ggcatctgca
     3241 tacacatgca cacatacaca gaatcttttt ttaaaaatga ataaaattca caaggaacag
     3301 cttaatataa tatatacctt cttgcctagg gagtctgaaa cagaattcta agttggggcc
     3361 tatctgggct acatagcaag cccttgactg aagaagaagg agaacagtgc tttaactgca
     3421 cttgaatgaa tgtggtatag agatgtgccc acagtaaatg taaacatacc tgtacagctg
     3481 gtgataaata gtaggttaga ggaaaagcca tattaagttg atatttaatt ggtacaatat
     3541 aactttttcc catgtcatat tttaattttc atgattaact gagatgaaaa tgcatagagt
     3601 aattctttga ctttttttaa ttcttttgac tttttttgca ggagtcttag ctaaatttga
     3661 caggtttaat tcaggtttaa ttcaggtttt tgttaccatc tctgttactt tggctctgac
     3721 tgccctcttt ttatcaagtt tttcttagaa aataatgtaa ctctgttctg cttgtgttcc
     3781 tgaaaaagca ccaagggaag ctgtgaggtt tccacctcac attgaagcct ttaaccaggg
     3841 gcaagagggg ccaggaagtg tggtgctaag cagagttaga agataagtga gaaaatgggc
     3901 cattaaaaag gcttggttat cacctacatg ctctcttaag gaacgtactc tgtatagctg
     3961 ccggtggttt catttcccat ttccatacag aaacagatgt aaggcatgga ttgacgaggg
     4021 aactgctggt agccctggga tgatactctc ctgtcctttg catcttcagg cagaaacagg
     4081 tctgaacaat ggcgtagcag ctacagtctc catgtcaaga ccaatcccac ccttcacagt
     4141 tggtaacgtt aatgttggct tctgtgctac ctgtcatgac ttaagtgtca ccagctcctt
     4201 gacagtattc ttccagagaa cttgtgtcat gttcctgcag ccatgtatgt gagtgctcag
     4261 ggaacttgaa gagataatct catgaagtgt gctgggaatt agcactgtga cacatgtagc
     4321 agagcaggcc agtttcttga tggaattggt aggtctctat gaaaggtgac agtagctttg
     4381 gcattctttg tcccgtgttt taagtagaga attgttgctg gaagatagtg gtgcacactc
     4441 tttatcccag cactttggag gcagaggcag gctgatctct gaattctaca gactgagttc
     4501 caagacagcc agagaaaccc tgtctcaaaa tgtagaaaaa ttgttaacac tgttagagac
     4561 acagatagtt gacaatagag gtagtcaccc cattctgctt tggttttgtt ctgctgcctc
     4621 ccctccctcc cctcacccct gttttccttt ggtattttag acattgatca gtcatatctc
     4681 agagggctgg aataagaaaa atctatacac aggtgaacac ttgtactagt gagagtttac
     4741 tttgtactag aaaatgggaa ttgggtagtg ggccttgcta agaccatcaa gaaactaggt
     4801 ttaagctgtg ttctaagctg gtacaaatga cctgtcagag gaccccttta ccttcagctc
     4861 cccttctgag atcctaaatt ctgaattcag aatcaggatg gcagaagaca gtaatggagc
     4921 ttttaagttc ttaatggtaa ttgaaacaaa acaggatgtg aaacagtaag aggtaacttt
     4981 aatttgaata gggcagtttg ttgctattat atataatatg taatggtgtg gaaccaaatt
     5041 taaaatactt tgagaaattc acatagaaca ttttaggatc aagcaccagg tgaaaaccaa
     5101 tcattttagg acctaccatg gtcatgtaca tgtgattcca acactggagg ctaaggcaga
     5161 aggattagga gttgggggcc agtctggatt acttagcaag ttcaggacaa cctaagcggg
     5221 tgtacagagt gaaacctgcc ctgggtttgg gggtggggtg gggtgggcgt gatggtggag
     5281 taacacattg cattaaaatt agttttaaaa tgataaaagc tatttcagat aactgcctta
     5341 aatttcctac aataattaaa acttggaatt cgaagttttt gtgtatttgt atactccatc
     5401 ctaccttcgt atatagactt ccaaaggtta atgtcctaac agccgctaca atgtttactc
     5461 atgaaaaccc agctagtaaa tattggtgtt cagggctgcc agcttgccca gtccttgggg
     5521 ttctgttcac atagaacaca attcggagtt gatcaaacac tgttgcactt tgcttcatac
     5581 ttcaaaacaa ctttcattag gagctcacat gctgtcactt agacaaaatt aactcactgt
     5641 gacctttttg ctgttcttac atagtactga ctctagtgtt gtcatttcag tgagaattca
     5701 gtctgtctgt cttcgggaaa cggctctagt tctaggcagt gagaagcagc tctttagcat
     5761 ccgcaaagtg tgctattttc tcttcctttg acttgttcgg aatacagtgg tgtgtcctca
     5821 tttgttacac gtattaccat aatattaatg catcttaata aatcagttgg aatata
//
LOCUS       NM_001001504            3279 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus GTF2I repeat domain containing 1 (Gtf2ird1),
            transcript variant 2, mRNA.
ACCESSION   NM_001001504 XM_341063 XM_347152
VERSION     NM_001001504.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3279)
  AUTHORS   Ganaie,I.A., Malik,M.Z., Naqvi,S.H., Jain,S.K. and Wajid,S.
  TITLE     Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy
            chain variable region, and Hypertrophied skeletal muscle protein
            GTF3 in rat mammary tumorigenesis
  JOURNAL   Biochimie 174, 57-68 (2020)
   PUBMED   32325114
  REMARK    GeneRIF: Differential levels of Alpha-1-inhibitor III,
            Immunoglobulin heavy chain variable region, and Hypertrophied
            skeletal muscle protein GTF3 in rat mammary tumorigenesis.
REFERENCE   2  (bases 1 to 3279)
  AUTHORS   Palmer,S.J., Taylor,K.M., Santucci,N., Widagdo,J., Chan,Y.K.,
            Yeo,J.L., Adams,M., Gunning,P.W. and Hardeman,E.C.
  TITLE     GTF2IRD2 from the Williams-Beuren critical region encodes a
            mobile-element-derived fusion protein that antagonizes the action
            of its related family members
  JOURNAL   J Cell Sci 125 (Pt 21), 5040-5050 (2012)
   PUBMED   22899722
REFERENCE   3  (bases 1 to 3279)
  AUTHORS   Enkhmandakh,B., Makeyev,A.V., Erdenechimeg,L., Ruddle,F.H.,
            Chimge,N.O., Tussie-Luna,M.I., Roy,A.L. and Bayarsaihan,D.
  TITLE     Essential functions of the Williams-Beuren syndrome-associated
            TFII-I genes in embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 106 (1), 181-186 (2009)
   PUBMED   19109438
REFERENCE   4  (bases 1 to 3279)
  AUTHORS   Olofsson,P., Holmberg,J., Tordsson,J., Lu,S., Akerstrom,B. and
            Holmdahl,R.
  TITLE     Positional identification of Ncf1 as a gene that regulates
            arthritis severity in rats
  JOURNAL   Nat Genet 33 (1), 25-32 (2003)
   PUBMED   12461526
REFERENCE   5  (bases 1 to 3279)
  AUTHORS   Bayarsaihan,D. and Ruddle,F.H.
  TITLE     Isolation and characterization of BEN, a member of the TFII-I
            family of DNA-binding proteins containing distinct helix-loop-helix
            domains
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7342-7347 (2000)
   PUBMED   10861001
REFERENCE   6  (bases 1 to 3279)
  AUTHORS   Franke,Y., Peoples,R.J. and Francke,U.
  TITLE     Identification of GTF2IRD1, a putative transcription factor within
            the Williams-Beuren syndrome deletion at 7q11.23
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 296-304 (1999)
   PUBMED   10575229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_001001504.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF547389.1, AF547388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000012.1  27890617-27890886
            271-399             JAXUCZ010000012.1  27932371-27932499
            400-541             JAXUCZ010000012.1  27935456-27935597
            542-697             JAXUCZ010000012.1  27938763-27938918
            698-881             JAXUCZ010000012.1  27940418-27940601
            882-1192            JAXUCZ010000012.1  27945002-27945312
            1193-1282           JAXUCZ010000012.1  27945979-27946068
            1283-1366           JAXUCZ010000012.1  27947614-27947697
            1367-1550           JAXUCZ010000012.1  27954797-27954980
            1551-1576           JAXUCZ010000012.1  27958242-27958267
            1577-1685           JAXUCZ010000012.1  27960358-27960466
            1686-1723           JAXUCZ010000012.1  27961900-27961937
            1724-1804           JAXUCZ010000012.1  27962416-27962496
            1805-1894           JAXUCZ010000012.1  27963094-27963183
            1895-1942           JAXUCZ010000012.1  27966545-27966592
            1943-2008           JAXUCZ010000012.1  27967290-27967355
            2009-2192           JAXUCZ010000012.1  27968671-27968854
            2193-2242           JAXUCZ010000012.1  27970339-27970388
            2243-2299           JAXUCZ010000012.1  27970580-27970636
            2300-2383           JAXUCZ010000012.1  27973141-27973224
            2384-2567           JAXUCZ010000012.1  27975435-27975618
            2568-2596           JAXUCZ010000012.1  27976694-27976722
            2597-2674           JAXUCZ010000012.1  27989856-27989933
            2675-2867           JAXUCZ010000012.1  27990465-27990657
            2868-2905           JAXUCZ010000012.1  27994907-27994944
            2906-3039           JAXUCZ010000012.1  27996090-27996223
            3040-3279           JAXUCZ010000012.1  27997267-27997506
FEATURES             Location/Qualifiers
     source          1..3279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3279
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I repeat domain containing 1"
                     /db_xref="GeneID:246770"
                     /db_xref="RGD:620856"
     exon            1..270
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..399
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..3108
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     general transcription factor II I repeat domain-containing
                     1; general transcription factor II-I repeat
                     domain-containing protein 1-like"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 1 isoform 2"
                     /protein_id="NP_001001504.1"
                     /db_xref="GeneID:246770"
                     /db_xref="RGD:620856"
                     /translation="MALLGKHCDIPTNGCGSERWNSTFARKDELINSLVSALDSMCSA
                     LSKLNTEVACVAVHNESVFVMGTEKGRVFLNTRKELQSDFLRFCRGPLWNDPEAGHPK
                     KVQRCEGGGRSIPRSSLEQCSDVYLLQKMVEEVFDVLYSEAMGRATVVPLPYERLLRE
                     PGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLRRPPDDGGQDTKALVEMN
                     GISLLPKGSRDCGLHGQASKVSPQDLTPTATPSSMANFLYSTSMPNHTIRELKQEVPT
                     CPLTPSDLGLGWPVPEPHVPSTQDFSDCCGQAPAGPAGPLIQNVHASKRILFSIVHDK
                     SEKWDPFIKEMEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGI
                     PDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDPMKLEPASPP
                     EDTATEVCRDSMLDLAGTAWSDMSSVSEDCGPGTSGEIGMLRPIKIEPEELDIIQVTV
                     SDPSPTSEEMTDSLPGHLPSEDSGYGMEMPADKGPSEEPWQEERPAEESPGDVIRPLR
                     KQVEMLFNTKYAKAIGTSEPVKVPYSKFLMHPEELFVLGLPEGISLRRPNCFGIAKLR
                     KILEASNSIQFVIKRPELLTDGVKEPVMDTQERDSWDPLVDETPKRQGLQENYNTRLS
                     RIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKP
                     CTFGSQNLERILSVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEK
                     YGEALGLNRPVLVPYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKARDHVR
                     MVIINQLQPFGDVCNNAKVPAKDNIPKRKRKRVSEGNSVSSSSSSSSSSSSNPESVAS
                     TNQISLVQWPVYMVDYSGLNVQLPGPLDY"
     misc_feature    658..882
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    658..882
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1327..1551
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1327..1551
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1969..2193
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1969..2193
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2344..2568
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2344..2568
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2635..2853
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2635..2853
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     exon            400..541
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..697
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..881
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1192
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1282
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1366
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1550
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1576
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1685
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1723
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1804
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1894
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1942
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2008
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2192
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2242
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2299
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2383
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2567
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2596
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2674
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2867
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2905
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3039
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3279
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacaaaga gagaacctcc cagagcccgg gctcggcttc gcgctcgctc tgcgccccgc
       61 cctccgccgc agcccgcgcc gggggtgggg gccccgcgca gcccccggcc ggccgcccgc
      121 accgcgtccg ccctccttcc ctccctccct ccactgatcc tgtcccccac tcccggatta
      181 ttaactcagc aaccagaggc gactggatct accgagtcct ggccaccggg cccgggccgg
      241 ggcgcccgga gcgcttgggg atcctgcaag gtgaccatgg ccttgctggg gaagcattgt
      301 gacatcccca ccaacggctg tgggtctgag cgctggaact ccacctttgc ccgcaaggac
      361 gagctcatca acagtctggt gtctgcctta gactccatgt gctcagcgct ctccaagctg
      421 aacacagagg tggcctgcgt ggcggtacac aatgagagcg tcttcgtgat gggcaccgag
      481 aagggaaggg tgtttttgaa tactcggaag gagctacagt cagacttcct caggttctgc
      541 cggggacccc tgtggaacga tccagaagca ggacacccta aaaaggtgca gcgctgcgaa
      601 ggtggtggcc ggagcatccc gcggtcctct ctggagcagt gctcggatgt gtacctgctg
      661 cagaagatgg tagaggaagt gtttgatgtt ctttatagtg aggctatggg cagggccacc
      721 gtggtacctt tgccctatga gaggctgctc agggagccgg ggctactggc ggtgcagggg
      781 ctgcccgagg gcctggcctt ccggagacca gcagaatatg accccaaggc actcatggcc
      841 attttggagc atagtcaccg aattcggttt aagctcagga ggcctcctga tgacggtggg
      901 caggacacaa aggcgctggt ggagatgaac ggtatctctc tgctacccaa ggggtcccga
      961 gactgtggtc tgcatggcca ggcctccaag gtctctcccc aagacctgac ccccaccgcc
     1021 accccatcct ccatggccaa cttcctgtac agcacttcga tgcccaacca caccatccgg
     1081 gaactcaagc aggaggtgcc aacctgcccg ttgaccccca gcgacctggg cttgggctgg
     1141 cctgtgcctg agccccatgt ccccagcacc caagatttct ctgattgctg tggacaggcg
     1201 cctgcagggc ctgctgggcc tctcatccag aatgtccacg cttccaagcg tatcctcttc
     1261 tccatcgtcc acgacaagtc agagaagtgg gatcccttca tcaaggaaat ggaggacatc
     1321 aacaccctgc gggagtgcgt gcagattctg tttaacagca gatacgcgga agccctgggc
     1381 ctggaccata tggttcctgt gccctacagg aagattgcct gtgaccctga ggctgtggag
     1441 attgtgggta tcccagacaa gatccccttc aagcggccct gcacttatgg agtgccgaag
     1501 ctgaagagaa ttctggagga gcggcacagc attcacttca ttatcaagag gatgttcgat
     1561 gagcgcattt tcacagggaa caagtttacc aaagacccca tgaagctgga gccagctagc
     1621 ccaccagaag acactgccac agaagtctgt agggacagca tgctggacct ggctgggact
     1681 gcttggtcag acatgagcag cgtctctgaa gactgtgggc caggaacctc aggagagata
     1741 ggaatgttga ggcctatcaa aatcgagccc gaggagctgg acattattca ggttactgtc
     1801 tcagatcctt cacctacctc tgaggagatg actgactcac tacctgggca tctaccctca
     1861 gaagattccg gttatgggat ggaaatgccg gctgacaaag gccccagtga ggaaccgtgg
     1921 caagaagaga ggccggcaga agagagccct ggtgatgtga tcaggcccct ccggaagcag
     1981 gtggaaatgc tgttcaacac aaaatatgcc aaagccattg gtacctcaga gccagtcaag
     2041 gtgccctact ccaagttcct gatgcaccca gaggagctct tcgtactggg actgcctgaa
     2101 ggcatctctc ttcgaagacc caactgcttt gggattgcca agctgaggaa gattctggaa
     2161 gccagcaaca gtatccagtt tgtcattaag agacccgaac tactcactga cggtgtcaaa
     2221 gaacctgtta tggacactca agagagggac tcctgggacc ctcttgtgga cgagaccccg
     2281 aagagacagg gccttcaaga aaattacaac accagactct ctcggatcga catcgccaac
     2341 acgcttaggg aacaagtcca agacctgttt aacaagaaat acggtgaagc tctgggcatc
     2401 aaatacccag tgcaggtgcc ctacaagcga atcaaaagca atccaggctc ggtaatcatc
     2461 gaaggcctgc cccccgggat cccattccgc aagccctgca cctttggctc ccagaacctg
     2521 gaaaggatcc tctctgtggc tgacaagatc aagttcaccg tcaccaggcc atttcaagga
     2581 ctcatcccaa agcctgatga ggatgatgcc aacagactgg gggagaaggt gatcctccga
     2641 gagcaggtga aggagctctt caatgagaaa tacggtgagg ccctgggact gaatcggcct
     2701 gtgctggtcc cgtacaagct gatccgggac agcccggatg ccgtggaggt gaaaggcctc
     2761 ccagatgaca tccccttccg gaaccccaac acctacgaca tccatcggct ggagaagatc
     2821 ctgaaggcca gagaccacgt acggatggtt atcatcaacc agctccaacc ttttggggat
     2881 gtctgcaaca atgccaaggt gccagccaaa gacaacattc ccaagcgcaa gagaaagcgg
     2941 gtctctgaag gcaactcagt ctcctcctct tcctcttctt catcctcctc gtcctctaat
     3001 ccagagtctg tggcgtccac caaccagatc tccctcgtgc agtggccagt gtacatggtg
     3061 gactattccg gactaaacgt gcagcttcca ggcccccttg attattagac ctcagagccg
     3121 aatcaggacc tcaactcaaa agactaaagg aaaatgtaat ttatgtacaa agtatattcg
     3181 gatatgtatc gatgcctttt agtttttcca atgattttta cactatattc ctgccgccaa
     3241 ggccttttta aataagtaaa gaaaacgaaa aagaacaaa
//
LOCUS       NM_019376               1676 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, gamma (Ywhag), transcript
            variant 2, mRNA.
ACCESSION   NM_019376 XM_346430 XM_347353
VERSION     NM_019376.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Han,L., Tang,J., Zhu,S. and Zhu,J.
  TITLE     LncRNA SNHG7 Knockdown Aggravates Hepatic Ischemia-Reperfusion
            Injury and Promotes Apoptosis in Hemorrhagic Shock Pregnant Rats by
            Modulating miR-34a-5p/YWHAG Axis
  JOURNAL   Mol Biotechnol 65 (6), 983-996 (2023)
   PUBMED   36427097
  REMARK    GeneRIF: LncRNA SNHG7 Knockdown Aggravates Hepatic
            Ischemia-Reperfusion Injury and Promotes Apoptosis in Hemorrhagic
            Shock Pregnant Rats by Modulating miR-34a-5p/YWHAG Axis.
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Abu-Rumeileh,S., Baiardi,S., Polischi,B., Mammana,A.,
            Franceschini,A., Green,A., Capellari,S. and Parchi,P.
  TITLE     Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob
            disease in the era of RT-QuIC
  JOURNAL   J Neurol 266 (12), 3136-3143 (2019)
   PUBMED   31541342
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Otsuka,S., Sakakima,H., Terashi,T., Takada,S., Nakanishi,K. and
            Kikuchi,K.
  TITLE     Preconditioning exercise reduces brain damage and neuronal
            apoptosis through enhanced endogenous 14-3-3gamma after focal brain
            ischemia in rats
  JOURNAL   Brain Struct Funct 224 (2), 727-738 (2019)
   PUBMED   30478609
  REMARK    GeneRIF: Our findings suggest that preconditioning exercise prior
            to ischemia induces neuron- and astrocyte-mediated brain ischemic
            tolerance through increased expression of HIF-1alpha and
            14-3-3gamma, which are intrinsic protective factors; the
            upregulated 14-3-3gamma induced by preconditioning exercise reduces
            ischemic neuronal cell death through the 14-3-3gamma/p-beta-catenin
            Ser37/Bax/caspase 3 anti-apoptotic pathway.
            Erratum:[Brain Struct Funct. 2019 Mar;224(2):739-740. doi:
            10.1007/s00429-018-1815-x. PMID: 30560373]
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Kanata,E., Golanska,E., Villar-Pique,A., Karsanidou,A., Dafou,D.,
            Xanthopoulos,K., Schmitz,M., Ferrer,I., Karch,A., Sikorska,B.,
            Liberski,P.P., Sklaviadis,T., Zerr,I. and Llorens,F.
  TITLE     Cerebrospinal fluid neurofilament light in suspected sporadic
            Creutzfeldt-Jakob disease
  JOURNAL   J Clin Neurosci 60, 124-127 (2019)
   PUBMED   30309804
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Gerber,K.J., Squires,K.E. and Hepler,J.R.
  TITLE     14-3-3gamma binds regulator of G protein signaling 14 (RGS14) at
            distinct sites to inhibit the RGS14:Galphai-AlF4- signaling complex
            and RGS14 nuclear localization
  JOURNAL   J Biol Chem 293 (38), 14616-14631 (2018)
   PUBMED   30093406
  REMARK    GeneRIF: phosphorylation-independent binding of 14-3-3 has no
            effect on RGS14/Galphai interactions but, instead, inhibits
            (directly or indirectly) RGS14 nuclear import and nucleocytoplasmic
            shuttling
            Erratum:[J Biol Chem. 2019 Aug 9;294(32):12262. doi:
            10.1074/jbc.AAC119.101131. PMID: 31399537]
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Peyrl,A., Weitzdoerfer,R., Gulesserian,T., Fountoulakis,M. and
            Lubec,G.
  TITLE     Aberrant expression of signaling-related proteins 14-3-3 gamma and
            RACK1 in fetal Down syndrome brain (trisomy 21)
  JOURNAL   Electrophoresis 23 (1), 152-157 (2002)
   PUBMED   11824616
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Autieri,M.V. and Carbone,C.J.
  TITLE     14-3-3Gamma interacts with and is phosphorylated by multiple
            protein kinase C isoforms in PDGF-stimulated human vascular smooth
            muscle cells
  JOURNAL   DNA Cell Biol 18 (7), 555-564 (1999)
   PUBMED   10433554
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Martin,H., Rostas,J., Patel,Y. and Aitken,A.
  TITLE     Subcellular localisation of 14-3-3 isoforms in rat brain using
            specific antibodies
  JOURNAL   J Neurochem 63 (6), 2259-2265 (1994)
   PUBMED   7964746
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y. and
            Kondo,H.
  TITLE     Molecular cloning of rat cDNAs for beta and gamma subtypes of
            14-3-3 protein and developmental changes in expression of their
            mRNAs in the nervous system
  JOURNAL   Brain Res Mol Brain Res 17 (1-2), 135-146 (1993)
   PUBMED   8381897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_019376.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127496.1, SRR26360190.3315089.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000012.1  26381174-26381450
            278-942             JAXUCZ010000012.1  26406233-26406897
            943-1676            JAXUCZ010000012.1  26408759-26409492
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1676
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, gamma"
                     /db_xref="GeneID:56010"
                     /db_xref="RGD:62002"
     exon            1..277
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..934
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="tyrosine 3/tryptophan 5 -monooxygenase activation
                     protein, gamma polypeptide; tyrosine
                     3-monooxgenase/tryptophan 5-monooxgenase activation
                     protein, gamma polypeptide; 14-3-3 protein gamma-subtype;
                     tryosine 3-monooxgenase/tryptophan 5-monooxgenase
                     activation protein gamma polypeptide;
                     3-monooxygenase/tryptophan 5-monooxgenase activation
                     protein gamma polypeptide; tryosine
                     3-monooxgenase/tryptophan 5 monooxgenase activation
                     protein gamma; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, gamma polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein gamma"
                     /protein_id="NP_062249.1"
                     /db_xref="GeneID:56010"
                     /db_xref="RGD:62002"
                     /translation="MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNL
                     LSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLS
                     LLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEI
                     SKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDDDGGEGNN"
     misc_feature    191..193
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); acetylation site"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="14-3-3 gamma, an isoform of 14-3-3 protein; Region:
                     14-3-3_gamma; cd10024"
                     /db_xref="CDD:206760"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="14-3-3 gamma, an isoform of 14-3-3 protein; Region:
                     14-3-3_gamma; cd10024"
                     /db_xref="CDD:206760"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="propagated from UniProtKB/Swiss-Prot (P61983.2);
                     Region: Interaction with SPATA18/MIEAP.
                     /evidence=ECO:0000250|UniProtKB:P61981"
     misc_feature    194..196
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="N-acetylvaline, in 14-3-3 protein gamma,
                     N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); acetylation site"
     misc_feature    order(206..208,215..220,227..232,236..241,245..247,
                     254..256,365..367,374..379,386..388,419..424,431..436,
                     443..445,452..457,464..466)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:206760"
     misc_feature    order(206..208,215..220,227..232,236..241,245..247,
                     254..256,365..367,374..379,386..388,419..424,431..436,
                     443..445,452..457,464..466)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:206760"
     misc_feature    order(338..340,359..361,563..565,584..589,719..724,
                     731..733,854..856,863..865,875..877,884..889)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206760"
     misc_feature    order(338..340,359..361,563..565,584..589,719..724,
                     731..733,854..856,863..865,875..877,884..889)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206760"
     misc_feature    359..361
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250|UniProtKB:P61981;
                     propagated from UniProtKB/Swiss-Prot (P61983.2); other
                     site"
     misc_feature    401..403
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    584..586
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250|UniProtKB:P61981;
                     propagated from UniProtKB/Swiss-Prot (P61983.2); other
                     site"
     misc_feature    587..589
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    623..625
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    833..835
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    890..892
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    893..895
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     exon            278..942
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1676
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcctcct tgcgccgggt cccgcggtcg cagctcgtgc cgcctccttc tcgtcctcgc
       61 cttagcagct tgcttcgtgg gtcggtcctt ccgacacacg agctccaagc cgctcctctc
      121 ttttcctaaa gcccttcaag gcagtcttcg gtttccttct ttccagccga ccctcttcag
      181 ccccgcgaag atggtggacc gcgagcaact agtgcagaaa gcccggctgg ccgagcaggc
      241 ggagcgctac gacgatatgg ccgcggccat gaagaacgtg acagagctga atgaaccact
      301 gtccaacgag gaacggaacc tcctgtcggt ggcctacaag aacgtggttg gggctcgccg
      361 ctcctcctgg agggtcatca gcagcatcga gcagaagacg tctgcggatg gcaacgagaa
      421 gaagatagag atggtccgag cctaccggga aaagattgag aaggagctgg aggccgtgtg
      481 ccaggacgtg ctgagcctgc tggacaacta cctgatcaag aactgcagcg agacccagta
      541 cgagagcaag gtgttctacc tgaagatgaa aggggactat taccgctacc tggccgaagt
      601 ggccactggg gagaaaaggg cgaccgtggt ggagtcgtcc gagaaggcct acagcgaagc
      661 ccacgagatc agcaaggagc acatgcagcc cacccacccc atccggctgg gcctggcgct
      721 caactactcc gttttctact acgagatcca gaacgcccca gagcaagcct gccacctggc
      781 caagaccgcc ttcgatgacg ccatcgccga gctcgacact ctgaacgagg actcctacaa
      841 ggactccact ctgatcatgc agctgctccg agacaaccta acgctctgga cgagcgacca
      901 gcaagacgac gacggcggcg aaggcaacaa ctaaggcccc agaaaagtca tgtgagggta
      961 gaactgaaga gggagagcgg gagacctgac gtgagcgtgg atggttcctt ctccttccct
     1021 tactgttgag aagcgcacct gcctctgatg ctgtctccgt tgccgcggtt gccccaccta
     1081 ttgatacagt attgtgcatg ctggtgttgt atttctatac ggtagctgac atttattacc
     1141 ttacactgta ggcgttatgt attcctatga caacaaaact taagacttca aaatcttttt
     1201 aaactttttt tttttaattt aattttttcc tttcaggggt aaagtttgct ttaccaaaaa
     1261 tagtggttgt aacaaattga tctgttttgg atgttgctat agtgacatgc agttctctat
     1321 tttgttttcg gggggagggg acaaaagaaa caccagtgtt agcttactct taatgtctgg
     1381 tgtttgtcat ggtgaaatta taactattac agtgttggag aacgccgcgg acgttctctg
     1441 aacgcacctc tgtgctttct tgtcatgtta tgcagtgaaa ctatttttaa ggtctaatca
     1501 agtgattttt tcccccccaa ctccgtgttt cgctaaggaa ttatttcgca cacggaccat
     1561 tcttagcagt ttcctcagtg atggaatatt catgaatgtg agtcattatg tagccgtcgt
     1621 acattgagca aaataaactt acagatctga tgtcggtgct gcctagcttc atttaa
//
LOCUS       NM_001436447            1976 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 7, mRNA.
ACCESSION   NM_001436447 XM_006243701
VERSION     NM_001436447.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006243701.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.584314.1,
                                           SRR22399481.296533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JAXUCZ010000008.1  117870975-117871213
            240-314             JAXUCZ010000008.1  117880565-117880639
            315-472             JAXUCZ010000008.1  117894634-117894791
            473-593             JAXUCZ010000008.1  117897631-117897751
            594-724             JAXUCZ010000008.1  117901968-117902098
            725-1976            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1976
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..239
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..314
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            315..472
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..898
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_001423376.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     317..886
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    329..853
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    329..853
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(329..331,416..418,425..430,437..439,443..445,
                     449..451,476..478,488..493,497..505,512..514,518..520,
                     530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(329..331,416..418,425..430,437..439,443..445,
                     449..451,476..478,488..493,497..505,512..514,518..520,
                     530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    350..373
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    350..373
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(359..376,416..421,425..427,491..496,668..670,
                     674..676,797..802)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(359..376,416..421,425..427,491..496,668..670,
                     674..676,797..802)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(383..385,389..403,440..445,449..457,470..478,
                     803..808,818..823,830..832)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(383..385,389..403,440..445,449..457,470..478,
                     803..808,818..823,830..832)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(416..418,422..424,428..433,503..514,521..523,
                     530..532,596..598)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(416..418,422..424,428..433,503..514,521..523,
                     530..532,596..598)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    416..442
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(425..430,497..499,512..514,518..523,527..532,
                     539..541,629..634,638..640)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(425..430,497..499,512..514,518..523,527..532,
                     539..541,629..634,638..640)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    425..427
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    425..427
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(431..433,509..523,530..532,605..607,617..619,
                     629..631)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(431..433,509..523,530..532,605..607,617..619,
                     629..631)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(431..436,509..514,518..523,530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(431..436,509..514,518..523,530..532)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    491..502
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    491..502
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    497..550
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    500..553
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    500..553
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    665..676
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    665..676
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    794..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    794..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    878..880
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    884..886
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            473..593
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..724
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1976
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcagggc tgcgccgggc tgggcggggg ctcccggccg gcccgcgacc gcgctggggt
       61 agcctaccac tgcgaagcgc gtgtggctgt cgggagttga aataggcaag aaactcttgt
      121 acaactccat tttgcctttt acattgaacg aggatcatta atcaccgttt tataccgtgt
      181 gaagacagtg aggctttggg tggattttct gttttctttg ccgtattatt ggaagttgtc
      241 cttgcatcta agaagtccca ggtactttgt acaactgcat cccagaagct gagtttcttc
      301 agcaccttca taagtgatgg ctgccatcag gaagaaactg gtgattgttg gtgatggagc
      361 ttgtggtaag acatgcttgc tcatagtctt cagcaaggac cagttcccag aggtttatgt
      421 gcccacggtg tttgaaaact atgtggcaga tattgaagtg gacgggaagc aggtagagtt
      481 ggctttatgg gacacagctg gacaggaaga ttatgaccgt ctgaggcctc tctcctaccc
      541 agacactgat gttatactga tgtgtttttc catcgacagc cctgatagtt tagaaaacat
      601 cccagaaaaa tggactccag aagtcaagca tttctgtcca aatgtgccca tcatcctagt
      661 tgggaacaag aaggatcttc ggaatgatga gcacacaagg cgggagttag ccaaaatgaa
      721 gcaggagccg gtaaaacctg aagaaggcag agatatggca aacaggattg gcgcttttgg
      781 gtacatggag tgttcagcaa agaccaaaga cggagtgaga gaggtttttg agatggccac
      841 gagagctgct ctgcaagcta gacgcgggaa gaaaaagtcg gggtgcctca tcttgtgaag
      901 ccttgtgacg cgcagcctca tgcggttaat ttgaagtgct gtttattaat cttagtgtat
      961 gattactggc cttttcattt atctataatt tacctaagat tacaaatcag aagtcatctt
     1021 gctaccagta tttagaagcc aaccatgatt attaatgatg tccagcctgt ctgaccagcc
     1081 agggtccttc tgacactgct ctaacgccct ctctgcactc cacctgacac caggcgctca
     1141 ttcaaagaat ttcttaactt cctgcttctt tctagaaaga gaaacagttg gtaacttttg
     1201 tgaattaggc tgtaactact ttataactaa catgtcctgc ctattttctg tcagctgcga
     1261 ggaactctgg tgagtcacta cttcagagct ttactcctta acagattcca ttggcagagc
     1321 tctggggtgg gcacccagtg tttggaaact tgatcagcca gaaaggccca agtccacgca
     1381 gctgtggcag agttacagtt ctgtggtctc atgttagtta ccttatagtt actgtgtaat
     1441 tagtgccact taatgtatgt taccaaaaat aaatatatct accccagact agatgtagta
     1501 ttttttgtat aattggattt cctaattctg atatttgtca ttcccacaga aagtgtattg
     1561 cttttttttt tttttaagaa agtatttgga aataaagtca gatggaaaat tcatttttaa
     1621 aattcccatt ttgtcacttt ctctgataaa atatggccat atctccccta tttagcccta
     1681 tatatcattc cagtgcccct ttccagactg gactgaggaa ataggaattg gtttcatgcc
     1741 tgaggctgtt agactttgga ggtggcatag cctttctcac ctggactgca gggcctggct
     1801 ctaagtcaca gtgctccttt ctccacactg ttatccaagt cgcctcccag aggagccacc
     1861 agttcttatg ggtggcaatg ggtgggtggg tggggggtct cctctctcca gctgactaaa
     1921 cttttttctg taccagttaa tttttccaac taatagaata aaggcagttt tctaaa
//
LOCUS       NM_001436438            3650 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 9, mRNA.
ACCESSION   NM_001436438 XM_063266252
VERSION     NM_001436438.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3650)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3650)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3650)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3650)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3650)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3650)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3650)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3650)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3650)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3650)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266252.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1971005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-472             JAXUCZ010000008.1  28220002-28220231
            473-650             JAXUCZ010000008.1  28220683-28220860
            651-798             JAXUCZ010000008.1  28223540-28223687
            799-890             JAXUCZ010000008.1  28224972-28225063
            891-986             JAXUCZ010000008.1  28225440-28225535
            987-1098            JAXUCZ010000008.1  28226074-28226185
            1099-1196           JAXUCZ010000008.1  28226611-28226708
            1197-1308           JAXUCZ010000008.1  28227262-28227373
            1309-1419           JAXUCZ010000008.1  28227460-28227570
            1420-1619           JAXUCZ010000008.1  28228703-28228902
            1620-1787           JAXUCZ010000008.1  28229217-28229384
            1788-1910           JAXUCZ010000008.1  28230383-28230505
            1911-2087           JAXUCZ010000008.1  28230664-28230840
            2088-2244           JAXUCZ010000008.1  28230937-28231093
            2245-2298           JAXUCZ010000008.1  28231210-28231263
            2299-3650           JAXUCZ010000008.1  28231704-28233055
FEATURES             Location/Qualifiers
     source          1..3650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3650
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2348
                     /gene="Ilf3"
                     /note="isoform 9 is encoded by transcript variant 9; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 9"
                     /protein_id="NP_001423367.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSV
                     FPSDATTEGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQ
                     GAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFGM
                     GGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNSA
                     TAGYSDFFTDCYGYHDFGAS"
     misc_feature    393..494
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    438..440
                     /gene="Ilf3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    501..1265
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    537..539
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    801..803
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    807..809
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1182..1184
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1326..1442
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1350..1406
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1383..1385
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1389..1391
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1431..1649
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1446..1448,1455..1460,1467..1472,1476..1478,
                     1518..1523,1527..1529,1533..1535,1584..1592,1599..1601)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1617..1619
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    1665..1667
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1668..1670
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1683..1685
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1695..1697
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1794..2009
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1794..2009
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1815..1817,1821..1826,1833..1835,1872..1874,
                     1881..1889,1899..1901,1947..1958)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1815..1817,1821..1826,1833..1835,1872..1874,
                     1881..1889,1899..1901,1947..1958)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    2106..2222
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            243..472
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..650
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..798
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..890
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..986
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1098
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1196
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1308
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1619
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1787
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1910
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2087
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2244
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2298
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..3650
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tgcgtcccat gagaattttt gtgaatgatg atcgccatgt gatggcaaag cattcttcag
      301 tatacccaac acaagaggag ctggaggctg tacagaacat ggtgtcccac actgagcggg
      361 ccctcaaggc tgtctctgac tggattgatg agcaggagaa aggcaacagc gagctctctg
      421 aagcagaaaa tatggacaca cccccagatg atgagagcaa agaaggggct ggggaacaga
      481 aggcggaaca catgactagg accctgaggg gcgtgatgcg ggtcggcctg gtagccaagg
      541 gtcttctgct caagggggac ttggatctgg agctggttct gctctgtaag gagaagccca
      601 caactgccct tctggacaag gtggctgaca acctggccat ccagcttact actgtaacag
      661 aagacaagta tgaaatactc caatctgtgg atgatgctgc gattgtgata aaaaacacaa
      721 aagagccccc cttgtccttg accatccatc tgacctcccc tgttgtcaga gaagaaatgg
      781 agaaagtatt agctggagaa acgctatcag tcaacgaccc cccggacgtt ctggacaggc
      841 agaaatgcct tgctgccttg gcgtccctcc gacacgccaa gtggttccag gctagagcca
      901 atgggctgaa gtcatgtgtc attgtcatcc gtgtcctaag ggacttgtgt acccgagtgc
      961 ccacctgggg tcctctcaga ggatggcctc tggagctgct gtgtgagaag tccatcggca
     1021 ctgccaatag gccaatgggt gctggtgaag ccctgcggag agtactggag tgcctggctt
     1081 ccggcatcgt aatgccagat ggttctggca tttatgaccc ttgtgaaaaa gaagccactg
     1141 atgctattgg gcatctagac agacagcaac gggaagatat cacacagagt gcgcagcatg
     1201 ctctgcggct tgctgccttt ggccagctcc ataaagtact gggaatggac ccactgcctt
     1261 ccaaaatgcc caagaaacca aagaacgaga acccggtgga ctatactgtt caaatccccc
     1321 ccagcaccac ctacgccatc acacccatga aacgccctat ggaagaagat ggggaggaga
     1381 agtctcccag caaaaagaaa aagaagatcc agaagaaaga ggagaaggct gagcctcccc
     1441 aagctatgaa tgccctgatg aggttaaacc agctgaagcc agggctacag tacaagctga
     1501 tctcccagac gggtcctgtt cacgctccca tcttcaccat gtctgtggag gtagacggca
     1561 gtacctttga ggcctcaggg ccatctaaaa agaccgccaa gctacatgtg gctgtgaagg
     1621 tgttacagga catgggattg ccaacaggcg ctgaaggcag agactccagc aagggggagg
     1681 actctgctga ggagtcagat gggaagccag cagtagtggc cccaccccct gtggtggaag
     1741 cagtctccaa ccccagttct gtcttccctt cagatgccac tactgagggg ccgattttga
     1801 ctaagcacgg caagaatcct gtaatggagc ttaatgagaa gagacgtggc ctcaaatatg
     1861 agctcatttc tgagacaggg ggcagccacg acaaacggtt tgttatggag gttgaggtgg
     1921 acggacagaa gtttcaaggt gctggctcaa acaaaaaggt agcaaaggct tatgctgcac
     1981 ttgccgcatt agagaagctt ttccctgacg cccctcttgc tcttgaagcc aacaagaaga
     2041 aaagagcccc tgtgcctgtc cgaggcggac ccaaatttgc tgccaagcca cataaccctg
     2101 gctttggcat gggaggcccc atgcataatg aagcgccccc acctcccaac atccgaggtc
     2161 ggggccgagg aggtaacatc cgagggcgag gacgggggcg aggatttggt ggcaccaacc
     2221 acggaggagg ctacatgaat gctggcgctg gatatggaag ctatgggtac agcagcaatt
     2281 cggccacagc aggctacagt gactttttca cagactgcta cggctatcat gattttgggg
     2341 cttcctagag cgtctaaaag tattgacaca aaatcaactt tttactccaa tttcctccaa
     2401 ctccaaaacc caaagtgtcc gtgctgtgtc cctgtgcttc actggggttc tcaaccgtgg
     2461 ctttccaccg cagcctgtct gaaactgtta gcctgcagac ttaagacaat ggcagtttct
     2521 atcatgagtt tgcctttgaa cttggtcatt tcgaagttca cactaagtgg aaaaaccctt
     2581 ttctcagaga atttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtag
     2641 ccttgcacag aattctagag ccagcgttgt tcagcatcaa ggcaaaagcc catcattgct
     2701 ttttatggaa agcattcttt tatttaaaga aacagataat ggcacgtttt aatctacctt
     2761 tgtcttaatt tacagcaggt tttgtatgca atttttaacc ttttcacaag ttttcacatc
     2821 tggttgatgc ctttggcagt gatgaaaact ttcagcacat ctgaatccac agcagctgac
     2881 ttttttcctt gccttttgaa tgagcatgta aacctctggg atggccagaa cttgtgtact
     2941 gcgtagagca gggcctccca ccttttgtaa atgctctggt gggtccttgg ggtgaggagg
     3001 ttctgtggct gctttagtta agagagtgaa cttgcaaagg catcaaaact gcgcttccgt
     3061 tacttgtgtg agaaatgaga caggcttgag aggagggaat aacgtaaaat tttgcaagtc
     3121 ctgattgcag cgtggactcc tggattgggt ttggctttgt tttctttttc acaatggggc
     3181 tttaaaactg agctggagga gcctgacaca tcccaccctt tttttccccc agcaaattgc
     3241 tgactttggc ccgaccaggg tctatactgc ctggcacaca gacactgaat ctgtgtgcct
     3301 agaatttgtc ccagtgtgta aagtggtggg gagccttgtg atattgtggt taggcctctg
     3361 ctttgtagtt tttgctgcag atttgcccct gccttgactt gcaagatttg acgtttattc
     3421 aggcaaaaag tggtcaaaat ggttactgtg tgatttgttc cccaaggttt aaaaagtcag
     3481 tgaaactttc taagattttg catgatgtat tttattttat ttttattttt tagaaagttc
     3541 ttgttggcaa ataatgtctt tttataccag gaaatagttc tgaatgacgt tgaagacctt
     3601 cccttcctta ttactattat tttttaaatg aatacatgtt aaagtaatga
//
LOCUS       NM_001436434            3561 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 5, mRNA.
ACCESSION   NM_001436434 XM_008765990
VERSION     NM_001436434.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3561)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3561)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3561)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_008765990.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2028564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-281             JAXUCZ010000008.1  28219581-28219619
            282-526             JAXUCZ010000008.1  28219987-28220231
            527-704             JAXUCZ010000008.1  28220683-28220860
            705-852             JAXUCZ010000008.1  28223540-28223687
            853-944             JAXUCZ010000008.1  28224972-28225063
            945-1040            JAXUCZ010000008.1  28225440-28225535
            1041-1152           JAXUCZ010000008.1  28226074-28226185
            1153-1250           JAXUCZ010000008.1  28226611-28226708
            1251-1362           JAXUCZ010000008.1  28227262-28227373
            1363-1473           JAXUCZ010000008.1  28227460-28227570
            1474-1673           JAXUCZ010000008.1  28228703-28228902
            1674-1841           JAXUCZ010000008.1  28229217-28229384
            1842-1967           JAXUCZ010000008.1  28230380-28230505
            1968-2144           JAXUCZ010000008.1  28230664-28230840
            2145-2301           JAXUCZ010000008.1  28230937-28231093
            2302-2355           JAXUCZ010000008.1  28231210-28231263
            2356-2721           JAXUCZ010000008.1  28234392-28234757
            2722-2850           JAXUCZ010000008.1  28235346-28235474
            2851-3561           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3561
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2987
                     /gene="Ilf3"
                     /note="isoform 5 is encoded by transcript variant 5; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 5"
                     /protein_id="NP_001423363.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRFSHFQRPMRIFVNDDRHVMAKHSSVYPTQE
                     ELEAVQNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEH
                     MTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTED
                     KYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDR
                     QKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKS
                     IGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQ
                     SAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPM
                     EEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIF
                     TMSVEVDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKP
                     AVVAPPPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETG
                     GSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPV
                     PVRGGPKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGG
                     GYMNAGAGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDS
                     YNSPVPPKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGH
                     GQGSYSSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGY
                     GAGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQY
                     R"
     misc_feature    555..1319
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    555..1319
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1485..1703
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1485..1703
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1500..1502,1509..1514,1521..1526,1530..1532,
                     1572..1577,1581..1583,1587..1589,1638..1646,1653..1655)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1500..1502,1509..1514,1521..1526,1530..1532,
                     1572..1577,1581..1583,1587..1589,1638..1646,1653..1655)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1851..2066
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1851..2066
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1872..1874,1878..1883,1890..1892,1929..1931,
                     1938..1946,1956..1958,2004..2015)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1872..1874,1878..1883,1890..1892,1929..1931,
                     1938..1946,1956..1958,2004..2015)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            243..281
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..526
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..704
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..852
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..944
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1040
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1152
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1250
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1362
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1473
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1673
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1841
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1967
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2301
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2355
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2721
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2850
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3561
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tggcattgta tcatcatcac ttcatcacaa gaagaagaag gttttcacat ttccagcgtc
      301 ccatgagaat ttttgtgaat gatgatcgcc atgtgatggc aaagcattct tcagtatacc
      361 caacacaaga ggagctggag gctgtacaga acatggtgtc ccacactgag cgggccctca
      421 aggctgtctc tgactggatt gatgagcagg agaaaggcaa cagcgagctc tctgaagcag
      481 aaaatatgga cacaccccca gatgatgaga gcaaagaagg ggctggggaa cagaaggcgg
      541 aacacatgac taggaccctg aggggcgtga tgcgggtcgg cctggtagcc aagggtcttc
      601 tgctcaaggg ggacttggat ctggagctgg ttctgctctg taaggagaag cccacaactg
      661 cccttctgga caaggtggct gacaacctgg ccatccagct tactactgta acagaagaca
      721 agtatgaaat actccaatct gtggatgatg ctgcgattgt gataaaaaac acaaaagagc
      781 cccccttgtc cttgaccatc catctgacct cccctgttgt cagagaagaa atggagaaag
      841 tattagctgg agaaacgcta tcagtcaacg accccccgga cgttctggac aggcagaaat
      901 gccttgctgc cttggcgtcc ctccgacacg ccaagtggtt ccaggctaga gccaatgggc
      961 tgaagtcatg tgtcattgtc atccgtgtcc taagggactt gtgtacccga gtgcccacct
     1021 ggggtcctct cagaggatgg cctctggagc tgctgtgtga gaagtccatc ggcactgcca
     1081 ataggccaat gggtgctggt gaagccctgc ggagagtact ggagtgcctg gcttccggca
     1141 tcgtaatgcc agatggttct ggcatttatg acccttgtga aaaagaagcc actgatgcta
     1201 ttgggcatct agacagacag caacgggaag atatcacaca gagtgcgcag catgctctgc
     1261 ggcttgctgc ctttggccag ctccataaag tactgggaat ggacccactg ccttccaaaa
     1321 tgcccaagaa accaaagaac gagaacccgg tggactatac tgttcaaatc ccccccagca
     1381 ccacctacgc catcacaccc atgaaacgcc ctatggaaga agatggggag gagaagtctc
     1441 ccagcaaaaa gaaaaagaag atccagaaga aagaggagaa ggctgagcct ccccaagcta
     1501 tgaatgccct gatgaggtta aaccagctga agccagggct acagtacaag ctgatctccc
     1561 agacgggtcc tgttcacgct cccatcttca ccatgtctgt ggaggtagac ggcagtacct
     1621 ttgaggcctc agggccatct aaaaagaccg ccaagctaca tgtggctgtg aaggtgttac
     1681 aggacatggg attgccaaca ggcgctgaag gcagagactc cagcaagggg gaggactctg
     1741 ctgaggagtc agatgggaag ccagcagtag tggccccacc ccctgtggtg gaagcagtct
     1801 ccaaccccag ttctgtcttc ccttcagatg ccactactga gcaggggccg attttgacta
     1861 agcacggcaa gaatcctgta atggagctta atgagaagag acgtggcctc aaatatgagc
     1921 tcatttctga gacagggggc agccacgaca aacggtttgt tatggaggtt gaggtggacg
     1981 gacagaagtt tcaaggtgct ggctcaaaca aaaaggtagc aaaggcttat gctgcacttg
     2041 ccgcattaga gaagcttttc cctgacgccc ctcttgctct tgaagccaac aagaagaaaa
     2101 gagcccctgt gcctgtccga ggcggaccca aatttgctgc caagccacat aaccctggct
     2161 ttggcatggg aggccccatg cataatgaag cgcccccacc tcccaacatc cgaggtcggg
     2221 gccgaggagg taacatccga gggcgaggac gggggcgagg atttggtggc accaaccacg
     2281 gaggaggcta catgaatgct ggcgctggat atggaagcta tgggtacagc agcaattcgg
     2341 ccacagcagg ctacagtcag ttctacagca atggagggca ttctgggaat gccggtggtg
     2401 gaggcagcgg gggaggtggt ggctcgtcca gctacagctc ctactaccaa ggagacagct
     2461 acaactcacc agtgcccccg aaacatgctg ggaagaagcc gctgcatggg ggccagcaga
     2521 aaccctccta cagctcgggc taccagtccc accagggcca gcagcaacct tacaaccaga
     2581 gccagtacag cagctacggc acgccacagg gcaagcagaa aggctatggc catgggcagg
     2641 gcagctactc ctcctactcc aactcttaca actcccctgg tggtggtggg ggctctgact
     2701 acagctacga cagcaaattc aactacagtg gtagtggagg ccggagtgga gggaacagct
     2761 atggctccag cgggtcatcc tacaacacag gctcacatgg gggttatggc gcaggttctg
     2821 gaggcagctc ttcataccaa ggcaaacaag gaggctactc atcacagtca aactacagct
     2881 cccctgggtc cagccagagc tacagcggcc ccgccagctc ctaccagtcc tcacagggtg
     2941 gctacagtcg gaacacagaa cacagcatga actaccagta cagataaagg cccaggctgc
     3001 ccctctcaac cttctgcacc tctgcctcca acttgtctcg ggagattgag tctgcacatc
     3061 accagttgcc atgtccactg ggccagtgcc cacccgtcca cgttgctgac gttgccacgc
     3121 tgtgaggcgt ggtggtccct gggacccgtg ctgtgaccct atttagctgt gttttggact
     3181 cagtgtcttc agtggtttgt tagttaccat tacaccttgt ctgagtagtg ttccgagttc
     3241 ttgccgtgcg gaatccctct gtctgtttat gcccggtgtg agttccatcg ggtgtcttta
     3301 aatagttgca gaagggatac gtcatctgtt aatgcttttt gtgaagtgag ttaaatgagc
     3361 tttcattatt ttaatgctta gtgtttcagt tttataagtg aaaattttat tttaaaaaac
     3421 agtggggttt gtttttttgt ttttttgtct ttgtttttgt tttttttttt tttttttttt
     3481 ttttttttgg tatgtctgga tcattcaggc agtacatttg aattccgctg aatgtagata
     3541 aataaaagaa aaacaaaaca g
//
LOCUS       NM_001436441            3604 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 13, mRNA.
ACCESSION   NM_001436441 XM_039082212
VERSION     NM_001436441.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3604)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3604)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3604)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3604)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3604)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3604)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3604)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3604)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3604)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3604)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_039082212.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.765712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-241             JAXUCZ010000008.1  28209003-28209099
            242-339             JAXUCZ010000008.1  28219161-28219258
            340-569             JAXUCZ010000008.1  28220002-28220231
            570-747             JAXUCZ010000008.1  28220683-28220860
            748-895             JAXUCZ010000008.1  28223540-28223687
            896-987             JAXUCZ010000008.1  28224972-28225063
            988-1083            JAXUCZ010000008.1  28225440-28225535
            1084-1195           JAXUCZ010000008.1  28226074-28226185
            1196-1293           JAXUCZ010000008.1  28226611-28226708
            1294-1405           JAXUCZ010000008.1  28227262-28227373
            1406-1516           JAXUCZ010000008.1  28227460-28227570
            1517-1716           JAXUCZ010000008.1  28228703-28228902
            1717-1884           JAXUCZ010000008.1  28229217-28229384
            1885-2010           JAXUCZ010000008.1  28230380-28230505
            2011-2187           JAXUCZ010000008.1  28230664-28230840
            2188-2344           JAXUCZ010000008.1  28230937-28231093
            2345-2398           JAXUCZ010000008.1  28231210-28231263
            2399-2764           JAXUCZ010000008.1  28234392-28234757
            2765-2893           JAXUCZ010000008.1  28235346-28235474
            2894-3604           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3604
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..241
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..339
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    301..303
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             337..3030
                     /gene="Ilf3"
                     /note="isoform 3 is encoded by transcript variant 13; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 3"
                     /protein_id="NP_001423370.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVSNPSSV
                     FPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKF
                     QGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPHNPGFG
                     MGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYGYSSNS
                     ATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGG
                     QQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGG
                     GGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGGSSSYQGKQGGYS
                     SQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     misc_feature    490..591
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    535..537
                     /gene="Ilf3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    598..1362
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    598..1362
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    634..636
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    898..900
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    904..906
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1279..1281
                     /gene="Ilf3"
                     /note="Phosphothreonine, by PKR.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1423..1539
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1447..1503
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1480..1482
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1486..1488
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1528..1746
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1528..1746
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1543..1545,1552..1557,1564..1569,1573..1575,
                     1615..1620,1624..1626,1630..1632,1681..1689,1696..1698)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1543..1545,1552..1557,1564..1569,1573..1575,
                     1615..1620,1624..1626,1630..1632,1681..1689,1696..1698)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1714..1716
                     /gene="Ilf3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); acetylation site"
     misc_feature    1732..1908
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1762..1764
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1765..1767
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1780..1782
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1792..1794
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    1894..2109
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1894..2109
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1915..1917,1921..1926,1933..1935,1972..1974,
                     1981..1989,1999..2001,2047..2058)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1915..1917,1921..1926,1933..1935,1972..1974,
                     1981..1989,1999..2001,2047..2058)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    2161..3027
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Interaction with PRMT1"
     misc_feature    2206..2322
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2494..3027
                     /gene="Ilf3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIL3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2716..2718
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2770..2772
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2776..2778
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     misc_feature    2788..2790
                     /gene="Ilf3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12906; propagated from
                     UniProtKB/Swiss-Prot (Q9JIL3.2); phosphorylation site"
     exon            340..569
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..747
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..895
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..987
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1083
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1195
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1293
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1405
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1516
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1716
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1884
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2010
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2187
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2344
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2398
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2764
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2893
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3604
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caaggagaac agaagagggt gtcggccttc ttgggacaga
      181 tgattgtaag ctgcatgtgg gtgccaggaa ctgaaccctg gttcctctgc aagagcagta
      241 aatagttgaa gtattggtaa caccaaggaa ctgtcacaat ttgaaaagat aagccaaggc
      301 tgatttccag acactacagg aaaaaaggag gggaaaatgc gtcccatgag aatttttgtg
      361 aatgatgatc gccatgtgat ggcaaagcat tcttcagtat acccaacaca agaggagctg
      421 gaggctgtac agaacatggt gtcccacact gagcgggccc tcaaggctgt ctctgactgg
      481 attgatgagc aggagaaagg caacagcgag ctctctgaag cagaaaatat ggacacaccc
      541 ccagatgatg agagcaaaga aggggctggg gaacagaagg cggaacacat gactaggacc
      601 ctgaggggcg tgatgcgggt cggcctggta gccaagggtc ttctgctcaa gggggacttg
      661 gatctggagc tggttctgct ctgtaaggag aagcccacaa ctgcccttct ggacaaggtg
      721 gctgacaacc tggccatcca gcttactact gtaacagaag acaagtatga aatactccaa
      781 tctgtggatg atgctgcgat tgtgataaaa aacacaaaag agcccccctt gtccttgacc
      841 atccatctga cctcccctgt tgtcagagaa gaaatggaga aagtattagc tggagaaacg
      901 ctatcagtca acgacccccc ggacgttctg gacaggcaga aatgccttgc tgccttggcg
      961 tccctccgac acgccaagtg gttccaggct agagccaatg ggctgaagtc atgtgtcatt
     1021 gtcatccgtg tcctaaggga cttgtgtacc cgagtgccca cctggggtcc tctcagagga
     1081 tggcctctgg agctgctgtg tgagaagtcc atcggcactg ccaataggcc aatgggtgct
     1141 ggtgaagccc tgcggagagt actggagtgc ctggcttccg gcatcgtaat gccagatggt
     1201 tctggcattt atgacccttg tgaaaaagaa gccactgatg ctattgggca tctagacaga
     1261 cagcaacggg aagatatcac acagagtgcg cagcatgctc tgcggcttgc tgcctttggc
     1321 cagctccata aagtactggg aatggaccca ctgccttcca aaatgcccaa gaaaccaaag
     1381 aacgagaacc cggtggacta tactgttcaa atccccccca gcaccaccta cgccatcaca
     1441 cccatgaaac gccctatgga agaagatggg gaggagaagt ctcccagcaa aaagaaaaag
     1501 aagatccaga agaaagagga gaaggctgag cctccccaag ctatgaatgc cctgatgagg
     1561 ttaaaccagc tgaagccagg gctacagtac aagctgatct cccagacggg tcctgttcac
     1621 gctcccatct tcaccatgtc tgtggaggta gacggcagta cctttgaggc ctcagggcca
     1681 tctaaaaaga ccgccaagct acatgtggct gtgaaggtgt tacaggacat gggattgcca
     1741 acaggcgctg aaggcagaga ctccagcaag ggggaggact ctgctgagga gtcagatggg
     1801 aagccagcag tagtggcccc accccctgtg gtggaagcag tctccaaccc cagttctgtc
     1861 ttcccttcag atgccactac tgagcagggg ccgattttga ctaagcacgg caagaatcct
     1921 gtaatggagc ttaatgagaa gagacgtggc ctcaaatatg agctcatttc tgagacaggg
     1981 ggcagccacg acaaacggtt tgttatggag gttgaggtgg acggacagaa gtttcaaggt
     2041 gctggctcaa acaaaaaggt agcaaaggct tatgctgcac ttgccgcatt agagaagctt
     2101 ttccctgacg cccctcttgc tcttgaagcc aacaagaaga aaagagcccc tgtgcctgtc
     2161 cgaggcggac ccaaatttgc tgccaagcca cataaccctg gctttggcat gggaggcccc
     2221 atgcataatg aagcgccccc acctcccaac atccgaggtc ggggccgagg aggtaacatc
     2281 cgagggcgag gacgggggcg aggatttggt ggcaccaacc acggaggagg ctacatgaat
     2341 gctggcgctg gatatggaag ctatgggtac agcagcaatt cggccacagc aggctacagt
     2401 cagttctaca gcaatggagg gcattctggg aatgccggtg gtggaggcag cgggggaggt
     2461 ggtggctcgt ccagctacag ctcctactac caaggagaca gctacaactc accagtgccc
     2521 ccgaaacatg ctgggaagaa gccgctgcat gggggccagc agaaaccctc ctacagctcg
     2581 ggctaccagt cccaccaggg ccagcagcaa ccttacaacc agagccagta cagcagctac
     2641 ggcacgccac agggcaagca gaaaggctat ggccatgggc agggcagcta ctcctcctac
     2701 tccaactctt acaactcccc tggtggtggt gggggctctg actacagcta cgacagcaaa
     2761 ttcaactaca gtggtagtgg aggccggagt ggagggaaca gctatggctc cagcgggtca
     2821 tcctacaaca caggctcaca tgggggttat ggcgcaggtt ctggaggcag ctcttcatac
     2881 caaggcaaac aaggaggcta ctcatcacag tcaaactaca gctcccctgg gtccagccag
     2941 agctacagcg gccccgccag ctcctaccag tcctcacagg gtggctacag tcggaacaca
     3001 gaacacagca tgaactacca gtacagataa aggcccaggc tgcccctctc aaccttctgc
     3061 acctctgcct ccaacttgtc tcgggagatt gagtctgcac atcaccagtt gccatgtcca
     3121 ctgggccagt gcccacccgt ccacgttgct gacgttgcca cgctgtgagg cgtggtggtc
     3181 cctgggaccc gtgctgtgac cctatttagc tgtgttttgg actcagtgtc ttcagtggtt
     3241 tgttagttac cattacacct tgtctgagta gtgttccgag ttcttgccgt gcggaatccc
     3301 tctgtctgtt tatgcccggt gtgagttcca tcgggtgtct ttaaatagtt gcagaaggga
     3361 tacgtcatct gttaatgctt tttgtgaagt gagttaaatg agctttcatt attttaatgc
     3421 ttagtgtttc agttttataa gtgaaaattt tattttaaaa aacagtgggg tttgtttttt
     3481 tgtttttttg tctttgtttt tgtttttttt tttttttttt tttttttttt tggtatgtct
     3541 ggatcattca ggcagtacat ttgaattccg ctgaatgtag ataaataaaa gaaaaacaaa
     3601 acag
//
LOCUS       NM_001436439            3692 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 10, mRNA.
ACCESSION   NM_001436439 XM_008765996
VERSION     NM_001436439.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3692)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3692)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3692)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3692)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_008765996.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32700.1,
                                           SRR26643297.27536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-281             JAXUCZ010000008.1  28219581-28219619
            282-511             JAXUCZ010000008.1  28220002-28220231
            512-689             JAXUCZ010000008.1  28220683-28220860
            690-837             JAXUCZ010000008.1  28223540-28223687
            838-929             JAXUCZ010000008.1  28224972-28225063
            930-1025            JAXUCZ010000008.1  28225440-28225535
            1026-1137           JAXUCZ010000008.1  28226074-28226185
            1138-1235           JAXUCZ010000008.1  28226611-28226708
            1236-1347           JAXUCZ010000008.1  28227262-28227373
            1348-1458           JAXUCZ010000008.1  28227460-28227570
            1459-1658           JAXUCZ010000008.1  28228703-28228902
            1659-1826           JAXUCZ010000008.1  28229217-28229384
            1827-1952           JAXUCZ010000008.1  28230380-28230505
            1953-2129           JAXUCZ010000008.1  28230664-28230840
            2130-2286           JAXUCZ010000008.1  28230937-28231093
            2287-2340           JAXUCZ010000008.1  28231210-28231263
            2341-3692           JAXUCZ010000008.1  28231704-28233055
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3692
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2390
                     /gene="Ilf3"
                     /note="isoform 10 is encoded by transcript variant 10; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform
                     10"
                     /protein_id="NP_001423368.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRRPMRIFVNDDRHVMAKHSSVYPTQEELEAV
                     QNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTL
                     RGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEIL
                     QSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLA
                     ALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTAN
                     RPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHA
                     LRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGE
                     EKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVE
                     VDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAP
                     PPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDK
                     RFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGG
                     PKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNA
                     GAGYGSYGYSSNSATAGYSDFFTDCYGYHDFGAS"
     misc_feature    540..1304
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    540..1304
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1470..1688
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1470..1688
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1485..1487,1494..1499,1506..1511,1515..1517,
                     1557..1562,1566..1568,1572..1574,1623..1631,1638..1640)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1485..1487,1494..1499,1506..1511,1515..1517,
                     1557..1562,1566..1568,1572..1574,1623..1631,1638..1640)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1836..2051
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1836..2051
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1857..1859,1863..1868,1875..1877,1914..1916,
                     1923..1931,1941..1943,1989..2000)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1857..1859,1863..1868,1875..1877,1914..1916,
                     1923..1931,1941..1943,1989..2000)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            243..281
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..511
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..689
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            690..837
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..929
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1025
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1137
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1235
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1347
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1658
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1826
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1952
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2129
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2286
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2340
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..3692
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tggcattgta tcatcatcac ttcatcacaa gaagaagaag gcgtcccatg agaatttttg
      301 tgaatgatga tcgccatgtg atggcaaagc attcttcagt atacccaaca caagaggagc
      361 tggaggctgt acagaacatg gtgtcccaca ctgagcgggc cctcaaggct gtctctgact
      421 ggattgatga gcaggagaaa ggcaacagcg agctctctga agcagaaaat atggacacac
      481 ccccagatga tgagagcaaa gaaggggctg gggaacagaa ggcggaacac atgactagga
      541 ccctgagggg cgtgatgcgg gtcggcctgg tagccaaggg tcttctgctc aagggggact
      601 tggatctgga gctggttctg ctctgtaagg agaagcccac aactgccctt ctggacaagg
      661 tggctgacaa cctggccatc cagcttacta ctgtaacaga agacaagtat gaaatactcc
      721 aatctgtgga tgatgctgcg attgtgataa aaaacacaaa agagcccccc ttgtccttga
      781 ccatccatct gacctcccct gttgtcagag aagaaatgga gaaagtatta gctggagaaa
      841 cgctatcagt caacgacccc ccggacgttc tggacaggca gaaatgcctt gctgccttgg
      901 cgtccctccg acacgccaag tggttccagg ctagagccaa tgggctgaag tcatgtgtca
      961 ttgtcatccg tgtcctaagg gacttgtgta cccgagtgcc cacctggggt cctctcagag
     1021 gatggcctct ggagctgctg tgtgagaagt ccatcggcac tgccaatagg ccaatgggtg
     1081 ctggtgaagc cctgcggaga gtactggagt gcctggcttc cggcatcgta atgccagatg
     1141 gttctggcat ttatgaccct tgtgaaaaag aagccactga tgctattggg catctagaca
     1201 gacagcaacg ggaagatatc acacagagtg cgcagcatgc tctgcggctt gctgcctttg
     1261 gccagctcca taaagtactg ggaatggacc cactgccttc caaaatgccc aagaaaccaa
     1321 agaacgagaa cccggtggac tatactgttc aaatcccccc cagcaccacc tacgccatca
     1381 cacccatgaa acgccctatg gaagaagatg gggaggagaa gtctcccagc aaaaagaaaa
     1441 agaagatcca gaagaaagag gagaaggctg agcctcccca agctatgaat gccctgatga
     1501 ggttaaacca gctgaagcca gggctacagt acaagctgat ctcccagacg ggtcctgttc
     1561 acgctcccat cttcaccatg tctgtggagg tagacggcag tacctttgag gcctcagggc
     1621 catctaaaaa gaccgccaag ctacatgtgg ctgtgaaggt gttacaggac atgggattgc
     1681 caacaggcgc tgaaggcaga gactccagca agggggagga ctctgctgag gagtcagatg
     1741 ggaagccagc agtagtggcc ccaccccctg tggtggaagc agtctccaac cccagttctg
     1801 tcttcccttc agatgccact actgagcagg ggccgatttt gactaagcac ggcaagaatc
     1861 ctgtaatgga gcttaatgag aagagacgtg gcctcaaata tgagctcatt tctgagacag
     1921 ggggcagcca cgacaaacgg tttgttatgg aggttgaggt ggacggacag aagtttcaag
     1981 gtgctggctc aaacaaaaag gtagcaaagg cttatgctgc acttgccgca ttagagaagc
     2041 ttttccctga cgcccctctt gctcttgaag ccaacaagaa gaaaagagcc cctgtgcctg
     2101 tccgaggcgg acccaaattt gctgccaagc cacataaccc tggctttggc atgggaggcc
     2161 ccatgcataa tgaagcgccc ccacctccca acatccgagg tcggggccga ggaggtaaca
     2221 tccgagggcg aggacggggg cgaggatttg gtggcaccaa ccacggagga ggctacatga
     2281 atgctggcgc tggatatgga agctatgggt acagcagcaa ttcggccaca gcaggctaca
     2341 gtgacttttt cacagactgc tacggctatc atgattttgg ggcttcctag agcgtctaaa
     2401 agtattgaca caaaatcaac tttttactcc aatttcctcc aactccaaaa cccaaagtgt
     2461 ccgtgctgtg tccctgtgct tcactggggt tctcaaccgt ggctttccac cgcagcctgt
     2521 ctgaaactgt tagcctgcag acttaagaca atggcagttt ctatcatgag tttgcctttg
     2581 aacttggtca tttcgaagtt cacactaagt ggaaaaaccc ttttctcaga gaatttgtgt
     2641 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt agccttgcac agaattctag
     2701 agccagcgtt gttcagcatc aaggcaaaag cccatcattg ctttttatgg aaagcattct
     2761 tttatttaaa gaaacagata atggcacgtt ttaatctacc tttgtcttaa tttacagcag
     2821 gttttgtatg caatttttaa ccttttcaca agttttcaca tctggttgat gcctttggca
     2881 gtgatgaaaa ctttcagcac atctgaatcc acagcagctg acttttttcc ttgccttttg
     2941 aatgagcatg taaacctctg ggatggccag aacttgtgta ctgcgtagag cagggcctcc
     3001 caccttttgt aaatgctctg gtgggtcctt ggggtgagga ggttctgtgg ctgctttagt
     3061 taagagagtg aacttgcaaa ggcatcaaaa ctgcgcttcc gttacttgtg tgagaaatga
     3121 gacaggcttg agaggaggga ataacgtaaa attttgcaag tcctgattgc agcgtggact
     3181 cctggattgg gtttggcttt gttttctttt tcacaatggg gctttaaaac tgagctggag
     3241 gagcctgaca catcccaccc tttttttccc ccagcaaatt gctgactttg gcccgaccag
     3301 ggtctatact gcctggcaca cagacactga atctgtgtgc ctagaatttg tcccagtgtg
     3361 taaagtggtg gggagccttg tgatattgtg gttaggcctc tgctttgtag tttttgctgc
     3421 agatttgccc ctgccttgac ttgcaagatt tgacgtttat tcaggcaaaa agtggtcaaa
     3481 atggttactg tgtgatttgt tccccaaggt ttaaaaagtc agtgaaactt tctaagattt
     3541 tgcatgatgt attttatttt atttttattt tttagaaagt tcttgttggc aaataatgtc
     3601 tttttatacc aggaaatagt tctgaatgac gttgaagacc ttcccttcct tattactatt
     3661 attttttaaa tgaatacatg ttaaagtaat ga
//
LOCUS       NM_001436453             785 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 3-like 1
            (Mbd3l1), transcript variant 3, mRNA.
ACCESSION   NM_001436453 XM_017595526
VERSION     NM_001436453.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 785)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_017595526.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2664997.1,
                                           SRR26360181.1108077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000008.1  24432245-24432295
            52-785              JAXUCZ010000008.1  24435954-24436687
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..785
                     /gene="Mbd3l1"
                     /note="methyl-CpG binding domain protein 3-like 1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
     exon            1..51
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            52..785
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Mbd3l1"
                     /note="upstream in-frame stop codon"
     CDS             70..630
                     /gene="Mbd3l1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3-like 1"
                     /protein_id="NP_001423382.1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
                     /translation="MGKTSQRKQCDCENPSKPCLSTSIPLRMSNYTFKRPVTKITSHL
                     GNEVRYYQWEETLEKPEQACWQKRLQGLQAYSSAGEILSTSDLSKALKDLTPRDTDAA
                     SSIIQANSMDPRPLSTLGSSSHLAKMIPEAGPQILCKEFLVTEEDISIQERKVKIARE
                     RLAVALIAHKLANETEKVRGSRKAKV"
     misc_feature    94..291
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    94..291
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    301..567
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
     misc_feature    301..567
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
ORIGIN      
        1 gacaacatat gaaggttcta aatcatccag agagctggtt agaggtaaga gggctaagaa
       61 cggagtcaga tgggcaagac ttcacagagg aagcaatgtg actgtgagaa tccatcaaag
      121 ccttgtttaa gtacctcaat ccccctgagg atgtctaatt atacattcaa gaggccagtc
      181 actaaaatca catcccatct gggcaatgag gtaagatact atcagtggga ggagaccttg
      241 gagaagccgg agcaagcctg ctggcaaaag agacttcaag gactccaggc ctacagcagt
      301 gcgggagaaa ttttgagcac ttcagacctt tccaaggctt tgaaagatct tacacctaga
      361 gacacagacg ccgcctcttc aatcattcaa gctaacagca tggaccccag gcccttgtcc
      421 acccttgggt catcttcaca tttggcaaag atgataccag aagcaggccc acagatcctt
      481 tgcaaagaat ttctggtcac tgaagaggat attagcatcc aggaaaggaa agtgaaaata
      541 gcaagagaaa gactggcagt ggcattgatt gcacacaagc tagcaaatga gacagagaaa
      601 gtgaggggtt caaggaaagc aaaggtataa acatgatggg gggagggagt actggggaaa
      661 agacactgca cgtgaaatgg ggcatagcct tgttttaacg cctctttgca gtctttagtt
      721 gttttgagac cttgaaactt taaacttaac aatactttat taaaagtctg tgcgatgcaa
      781 aaaaa
//
LOCUS       NM_001436436            3522 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 7, mRNA.
ACCESSION   NM_001436436 XM_008765993
VERSION     NM_001436436.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3522)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3522)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3522)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3522)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3522)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3522)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3522)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3522)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3522)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3522)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_008765993.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1549873.1,
                                           SRR26360194.2114172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-242             JAXUCZ010000008.1  28219161-28219258
            243-487             JAXUCZ010000008.1  28219987-28220231
            488-665             JAXUCZ010000008.1  28220683-28220860
            666-813             JAXUCZ010000008.1  28223540-28223687
            814-905             JAXUCZ010000008.1  28224972-28225063
            906-1001            JAXUCZ010000008.1  28225440-28225535
            1002-1113           JAXUCZ010000008.1  28226074-28226185
            1114-1211           JAXUCZ010000008.1  28226611-28226708
            1212-1323           JAXUCZ010000008.1  28227262-28227373
            1324-1434           JAXUCZ010000008.1  28227460-28227570
            1435-1634           JAXUCZ010000008.1  28228703-28228902
            1635-1802           JAXUCZ010000008.1  28229217-28229384
            1803-1928           JAXUCZ010000008.1  28230380-28230505
            1929-2105           JAXUCZ010000008.1  28230664-28230840
            2106-2262           JAXUCZ010000008.1  28230937-28231093
            2263-2316           JAXUCZ010000008.1  28231210-28231263
            2317-2682           JAXUCZ010000008.1  28234392-28234757
            2683-2811           JAXUCZ010000008.1  28235346-28235474
            2812-3522           JAXUCZ010000008.1  28235924-28236634
FEATURES             Location/Qualifiers
     source          1..3522
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3522
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..242
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             240..2948
                     /gene="Ilf3"
                     /note="isoform 7 is encoded by transcript variant 7; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform 7"
                     /protein_id="NP_001423365.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MFSHFQRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTE
                     RALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGL
                     VAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAI
                     VIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHA
                     KWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEA
                     LRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQ
                     LHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKK
                     KKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSTFEA
                     SGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAPPPVVEAVS
                     NPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEV
                     DGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGPKFAAKPH
                     NPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAGAGYGSYG
                     YSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKK
                     PLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYN
                     SPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSGGSSSYQGK
                     QGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     misc_feature    516..1280
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    516..1280
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1446..1664
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1446..1664
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1461..1463,1470..1475,1482..1487,1491..1493,
                     1533..1538,1542..1544,1548..1550,1599..1607,1614..1616)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1461..1463,1470..1475,1482..1487,1491..1493,
                     1533..1538,1542..1544,1548..1550,1599..1607,1614..1616)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    1812..2027
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    1812..2027
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(1833..1835,1839..1844,1851..1853,1890..1892,
                     1899..1907,1917..1919,1965..1976)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(1833..1835,1839..1844,1851..1853,1890..1892,
                     1899..1907,1917..1919,1965..1976)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            243..487
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            488..665
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..813
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..905
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1001
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1113
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1211
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1323
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1434
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1634
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1802
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1928
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2105
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2262
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2316
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2682
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2811
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3522
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caagatagtt gaagtattgg taacaccaag gaactgtcac
      181 aatttgaaaa gataagccaa ggctgatttc cagacactac aggaaaaaag gaggggaaaa
      241 tgttttcaca tttccagcgt cccatgagaa tttttgtgaa tgatgatcgc catgtgatgg
      301 caaagcattc ttcagtatac ccaacacaag aggagctgga ggctgtacag aacatggtgt
      361 cccacactga gcgggccctc aaggctgtct ctgactggat tgatgagcag gagaaaggca
      421 acagcgagct ctctgaagca gaaaatatgg acacaccccc agatgatgag agcaaagaag
      481 gggctgggga acagaaggcg gaacacatga ctaggaccct gaggggcgtg atgcgggtcg
      541 gcctggtagc caagggtctt ctgctcaagg gggacttgga tctggagctg gttctgctct
      601 gtaaggagaa gcccacaact gcccttctgg acaaggtggc tgacaacctg gccatccagc
      661 ttactactgt aacagaagac aagtatgaaa tactccaatc tgtggatgat gctgcgattg
      721 tgataaaaaa cacaaaagag ccccccttgt ccttgaccat ccatctgacc tcccctgttg
      781 tcagagaaga aatggagaaa gtattagctg gagaaacgct atcagtcaac gaccccccgg
      841 acgttctgga caggcagaaa tgccttgctg ccttggcgtc cctccgacac gccaagtggt
      901 tccaggctag agccaatggg ctgaagtcat gtgtcattgt catccgtgtc ctaagggact
      961 tgtgtacccg agtgcccacc tggggtcctc tcagaggatg gcctctggag ctgctgtgtg
     1021 agaagtccat cggcactgcc aataggccaa tgggtgctgg tgaagccctg cggagagtac
     1081 tggagtgcct ggcttccggc atcgtaatgc cagatggttc tggcatttat gacccttgtg
     1141 aaaaagaagc cactgatgct attgggcatc tagacagaca gcaacgggaa gatatcacac
     1201 agagtgcgca gcatgctctg cggcttgctg cctttggcca gctccataaa gtactgggaa
     1261 tggacccact gccttccaaa atgcccaaga aaccaaagaa cgagaacccg gtggactata
     1321 ctgttcaaat cccccccagc accacctacg ccatcacacc catgaaacgc cctatggaag
     1381 aagatgggga ggagaagtct cccagcaaaa agaaaaagaa gatccagaag aaagaggaga
     1441 aggctgagcc tccccaagct atgaatgccc tgatgaggtt aaaccagctg aagccagggc
     1501 tacagtacaa gctgatctcc cagacgggtc ctgttcacgc tcccatcttc accatgtctg
     1561 tggaggtaga cggcagtacc tttgaggcct cagggccatc taaaaagacc gccaagctac
     1621 atgtggctgt gaaggtgtta caggacatgg gattgccaac aggcgctgaa ggcagagact
     1681 ccagcaaggg ggaggactct gctgaggagt cagatgggaa gccagcagta gtggccccac
     1741 cccctgtggt ggaagcagtc tccaacccca gttctgtctt cccttcagat gccactactg
     1801 agcaggggcc gattttgact aagcacggca agaatcctgt aatggagctt aatgagaaga
     1861 gacgtggcct caaatatgag ctcatttctg agacaggggg cagccacgac aaacggtttg
     1921 ttatggaggt tgaggtggac ggacagaagt ttcaaggtgc tggctcaaac aaaaaggtag
     1981 caaaggctta tgctgcactt gccgcattag agaagctttt ccctgacgcc cctcttgctc
     2041 ttgaagccaa caagaagaaa agagcccctg tgcctgtccg aggcggaccc aaatttgctg
     2101 ccaagccaca taaccctggc tttggcatgg gaggccccat gcataatgaa gcgcccccac
     2161 ctcccaacat ccgaggtcgg ggccgaggag gtaacatccg agggcgagga cgggggcgag
     2221 gatttggtgg caccaaccac ggaggaggct acatgaatgc tggcgctgga tatggaagct
     2281 atgggtacag cagcaattcg gccacagcag gctacagtca gttctacagc aatggagggc
     2341 attctgggaa tgccggtggt ggaggcagcg ggggaggtgg tggctcgtcc agctacagct
     2401 cctactacca aggagacagc tacaactcac cagtgccccc gaaacatgct gggaagaagc
     2461 cgctgcatgg gggccagcag aaaccctcct acagctcggg ctaccagtcc caccagggcc
     2521 agcagcaacc ttacaaccag agccagtaca gcagctacgg cacgccacag ggcaagcaga
     2581 aaggctatgg ccatgggcag ggcagctact cctcctactc caactcttac aactcccctg
     2641 gtggtggtgg gggctctgac tacagctacg acagcaaatt caactacagt ggtagtggag
     2701 gccggagtgg agggaacagc tatggctcca gcgggtcatc ctacaacaca ggctcacatg
     2761 ggggttatgg cgcaggttct ggaggcagct cttcatacca aggcaaacaa ggaggctact
     2821 catcacagtc aaactacagc tcccctgggt ccagccagag ctacagcggc cccgccagct
     2881 cctaccagtc ctcacagggt ggctacagtc ggaacacaga acacagcatg aactaccagt
     2941 acagataaag gcccaggctg cccctctcaa ccttctgcac ctctgcctcc aacttgtctc
     3001 gggagattga gtctgcacat caccagttgc catgtccact gggccagtgc ccacccgtcc
     3061 acgttgctga cgttgccacg ctgtgaggcg tggtggtccc tgggacccgt gctgtgaccc
     3121 tatttagctg tgttttggac tcagtgtctt cagtggtttg ttagttacca ttacaccttg
     3181 tctgagtagt gttccgagtt cttgccgtgc ggaatccctc tgtctgttta tgcccggtgt
     3241 gagttccatc gggtgtcttt aaatagttgc agaagggata cgtcatctgt taatgctttt
     3301 tgtgaagtga gttaaatgag ctttcattat tttaatgctt agtgtttcag ttttataagt
     3361 gaaaatttta ttttaaaaaa cagtggggtt tgtttttttg tttttttgtc tttgtttttg
     3421 tttttttttt tttttttttt tttttttttg gtatgtctgg atcattcagg cagtacattt
     3481 gaattccgct gaatgtagat aaataaaaga aaaacaaaac ag
//
LOCUS       NM_001436459            2636 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 49 (Lrrc49),
            transcript variant 3, mRNA.
ACCESSION   NM_001436459 XM_063265147
VERSION     NM_001436459.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063265147.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.31470.1,
                                           SRR26643293.45708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000008.1  70056247-70056481   c
            236-323             JAXUCZ010000008.1  70053406-70053493   c
            324-426             JAXUCZ010000008.1  70048576-70048678   c
            427-630             JAXUCZ010000008.1  70045578-70045781   c
            631-697             JAXUCZ010000008.1  70039865-70039931   c
            698-841             JAXUCZ010000008.1  70037281-70037424   c
            842-903             JAXUCZ010000008.1  70019484-70019545   c
            904-1051            JAXUCZ010000008.1  69996747-69996894   c
            1052-1135           JAXUCZ010000008.1  69984849-69984932   c
            1136-1299           JAXUCZ010000008.1  69980873-69981036   c
            1300-1537           JAXUCZ010000008.1  69965190-69965427   c
            1538-1723           JAXUCZ010000008.1  69963925-69964110   c
            1724-1833           JAXUCZ010000008.1  69959742-69959851   c
            1834-1987           JAXUCZ010000008.1  69954547-69954700   c
            1988-2636           JAXUCZ010000008.1  69948964-69949612   c
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2636
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     exon            1..235
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="upstream in-frame stop codon"
     CDS             188..2191
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leucine-rich repeat-containing protein 49"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 49
                     isoform 3"
                     /protein_id="NP_001423388.1"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
                     /translation="MIPGKYRSVSGRAANNVEFKLNRETPSFPGRLLQHDLERNYSSR
                     QGDHINLVSSSMPSFPILQRSSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQH
                     NFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKN
                     LDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFV
                     RDVDNLPCLQRLFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQNM
                     MQLRQLDMKRITEEERRVASVVAKKEEEKKRESHKQSLLKEKKRLTINNVARKWDLQQ
                     RVANIAIIQDRKDSESPPQESCQIDGGTISAFPEEAGSLDAGLSSALQGLSVTETHLV
                     ELDGETLSLYGSGALECLDRNWSVQTAGMVTTVSFTFIEFDEIVQVLPKLKMKFPNSL
                     HLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKI
                     NGTEVTQNDMIMAERLFGILAHVASSELPQYRMISILGDARKKQFRYLLENKCKKPGI
                     LCEETSDSKRLMGENTNRATLNYTTREFYHEKLEEIKDKKKFCRLYVEDLVKEATAIN
                     MKNEALQKLWPQMFIELVRDAVIEIRSKDSYMKLCLQQITDQK"
     misc_feature    410..463
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    410..463
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    470..535
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    470..535
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    479..1066
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    479..1066
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    536..601
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    536..601
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    602..667
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    602..667
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    668..733
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    668..733
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    734..799
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    734..799
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    800..865
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    800..865
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    866..940
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    866..940
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            236..323
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            324..426
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            427..630
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            631..697
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            698..841
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            842..903
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1051
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1135
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1299
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1537
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1723
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1833
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1987
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2636
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagataatc cctgaggcta gccacccgga cggcccacag atctggggcg aggaccagac
       61 cggaaatggt ggtttctatg gtaacccctg aacaggttgc ctgggagatg accccttttg
      121 gtctctttga atcttagctg ttgcattacc tcgaaggagg atcgaacatc ctggactgtt
      181 tcctgccatg attcccggga aataccgctc cgtttctggc cgggctgcaa acaacgttga
      241 attcaagctt aatagagaaa caccatcatt tcctggtaga ctgttacagc atgacctgga
      301 gagaaactac tcaagtagac aaggtgatca cattaatctg gtgagctcat caatgccatc
      361 atttcctatt ctccagcgtt cttctgaaga gaaaactctt tactcagaca ggctgaccct
      421 agaaagacaa aagttgactg tgtgccctat catcgacggg gaggagcacc ttcgtttgtt
      481 gaactttcag cacaatttta taactcggat ccaaaatatt tctaatctac agaggctaat
      541 attcttggac ttatatgata accagattga agaaattagt gggctttcca ctctgaaatc
      601 ccttcgtgtc ctcctgttag ggaagaacag aatcaagaaa atctcaaatc tggagaatct
      661 aaaaaattta gatgtcttgg accttcatgg aaatcagatt accaaaattg aaaatgttaa
      721 tcatttgtgt gacttgagag ttttaaacct tgccaggaac ctcttgagtc atgttgacaa
      781 tctcaacggt ctggattcac taacagaact taaccttcgc cacaaccaga tcaccttcgt
      841 gagagatgtg gataatttgc cctgcctcca acgcctcttc ctcagcttca acaatataac
      901 tagctttgaa agtgtttcct gccttgctga gtcaacttcc ctctcagaca tcacctttga
      961 tggcaatcca atagctcaag agtcatggta caaacacacg gtccttcaga atatgatgca
     1021 gctgcgccag ctagacatga agagaatcac ggaagaagaa agacgcgtgg catctgttgt
     1081 ggccaaaaaa gaggaggaga agaagaggga gagtcacaag cagtccttgc tgaaggagaa
     1141 gaaaaggtta acaattaaca acgtcgctcg aaagtgggac ttgcagcaac gagtagccaa
     1201 tatcgccatc attcaggaca gaaaggactc tgagtctcct cctcaggaat cctgtcagat
     1261 cgatggaggc accatctccg catttcccga ggaagcaggg tctctagatg cgggactcag
     1321 cagtgcgtta caaggcttgt ctgtcacaga aacacacttg gtggagctag atggagaaac
     1381 cctgtcactg tatggctcag gggcgctgga atgcctagat cgtaactgga gtgttcaaac
     1441 agctggcatg gtcaccaccg tctcgttcac attcatcgag tttgatgaaa ttgtccaagt
     1501 acttcccaaa ctgaagatga agtttccaaa ttctctgcac cttaagttca gggagaccaa
     1561 ccttgtgatg ctgcagcagt tcaacgccct cgcgcaactt cgtcgggttg accagttgac
     1621 aatcgatcct cagggaaacc cagtggtgaa cttcacactc tggaagtact acgtgctgtt
     1681 taggctcagc cacttcagca tgcagaaaat aaatggaaca gaggtgacac aaaatgacat
     1741 gataatggct gaaaggctct ttggaatctt agcacatgtg gcatcctctg agctgcccca
     1801 gtaccgcatg atttcaattc tgggtgatgc caggaaaaag cagttccggt atctgctgga
     1861 gaacaaatgt aaaaagcctg gcatcctctg tgaggagacg agtgacagca agagattaat
     1921 gggggaaaac acaaaccgag ctaccctgaa ttacaccacc cgagaattct accacgagaa
     1981 gctggaggaa ataaaggaca agaagaagtt ctgcaggttg tatgtagaag acctggtgaa
     2041 ggaagccaca gccatcaaca tgaaaaatga ggctctgcag aagctgtggc cacagatgtt
     2101 catcgagctt gtcagggatg ccgtcataga gatccgcagc aaggactcct acatgaagct
     2161 ctgcctgcag cagatcactg accagaaata gggatggctc atgcttcaga catgggcaat
     2221 tggagctgtt ttaaagttgg gcaagatgca ggttagacat gatgagacat caccacttcc
     2281 gcacatacta gaaagagcgg catcaaagcc tcgccccctg cactgttgag gaggagggag
     2341 gcaggagaga gggggactct ttcccacgca tgctgaccac acaaccttgg ggacccgagc
     2401 agcaactgga gaaggcctgg ctgctgggtc agaaatgctt cttcagctcc tgctctgact
     2461 ggtgtgcctg cccccgtccc aggcacagtg cgtgctgatg ggcaagcatg agacgcctct
     2521 accaacctcc agctgagact tttctcttat tttgcctttt tattttatgt catgatttca
     2581 aagccaagct tatgttcttt tttatgagtg aaaaataaat acattagtaa aaaaaa
//
LOCUS       NM_001436448            1749 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus CDC-like kinase 3 (Clk3), transcript variant 1,
            mRNA.
ACCESSION   NM_001436448
VERSION     NM_001436448.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Ma,X., Gao,L., Ge,R., Yuan,T., Lin,B. and Zhen,L.
  TITLE     CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 333-342 (2024)
   PUBMED   38438604
  REMARK    GeneRIF: CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Duncan,P.I., Stojdl,D.F., Marius,R.M., Scheit,K.H. and Bell,J.C.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Becker,W., Kentrup,H., Heukelbach,J. and Joost,H.G.
  TITLE     cDNA cloning and characterization of rat Clk3, a LAMMER kinase
            predominately expressed in testis
  JOURNAL   Biochim Biophys Acta 1312 (1), 63-67 (1996)
   PUBMED   8679717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070891.1, SRR22399489.1990478.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000008.1  67062233-67062273   c
            42-193              JAXUCZ010000008.1  67058757-67058908   c
            194-410             JAXUCZ010000008.1  67057799-67058015   c
            411-507             JAXUCZ010000008.1  67055507-67055603   c
            508-574             JAXUCZ010000008.1  67055164-67055230   c
            575-691             JAXUCZ010000008.1  67052689-67052805   c
            692-858             JAXUCZ010000008.1  67051925-67052091   c
            859-953             JAXUCZ010000008.1  67050871-67050965   c
            954-1083            JAXUCZ010000008.1  67050644-67050773   c
            1084-1166           JAXUCZ010000008.1  67050006-67050088   c
            1167-1246           JAXUCZ010000008.1  67049514-67049593   c
            1247-1337           JAXUCZ010000008.1  67049175-67049265   c
            1338-1749           JAXUCZ010000008.1  67048121-67048532   c
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1749
                     /gene="Clk3"
                     /note="CDC-like kinase 3"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
     exon            1..41
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1514
                     /gene="Clk3"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3"
                     /protein_id="NP_001423377.1"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR"
     misc_feature    42..455
                     /gene="Clk3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63117.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    60..62
                     /gene="Clk3"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    66..68
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    186..188
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    192..194
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    240..242
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    267..269
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    273..275
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    444..446
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    465..1457
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    465..1457
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    order(525..539,549..551,591..593,597..599,639..641,
                     699..701,747..758,765..767,771..776,888..890,894..896,
                     900..905,909..911,999..1001,1008..1010,1035..1037,
                     1041..1052,1056..1058,1167..1169)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(525..539,549..551,591..593,597..599,639..641,
                     699..701,747..758,765..767,771..776,888..890,894..896,
                     900..905,909..911,999..1001,1008..1010,1035..1037,
                     1041..1052,1056..1058,1167..1169)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(525..536,549..551,591..593,597..599,699..701,
                     747..758,765..767,774..776,900..905,909..911,996..1001)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(525..536,549..551,591..593,597..599,699..701,
                     747..758,765..767,774..776,900..905,909..911,996..1001)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(639..641,771..773,888..890,894..896,1008..1010,
                     1035..1037,1041..1052,1056..1058,1167..1169)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(639..641,771..773,888..890,894..896,1008..1010,
                     1035..1037,1041..1052,1056..1058,1167..1169)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    996..1058
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     misc_feature    996..1058
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     exon            42..193
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            194..410
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..507
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..574
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..691
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..858
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..953
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1083
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1166
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1246
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1337
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1749
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggagtg gggcctagcc gcagccggag cctgggagac gatgcatcac tgtaagcgat
       61 accgttcccc agagccagac ccatacctga gctaccgctg gaagaggagg cggtcttaca
      121 gtcgggagca tgaaggtcga ctacgatacc catcccgaag ggagcctccc ccacggagat
      181 caaggtccag aagccatgat cgtataccct accagaggag gtaccgggaa caccgagaca
      241 gcgatacata tcggtgtgaa gagcggagcc catcctttgg agaggactgc tatgggtctt
      301 cacgttctcg acatcggaga cggtcacgag agagggggcc gtaccgtacc cgcaagcatg
      361 cccaccactg tcacaaacgt cgtaccaggt cttgtagcag cgcctcctcg agaagccaac
      421 agagcagtaa gcgcagcagc cggagtgtgg aagatgacaa ggagggccac ctggtgtgcc
      481 ggatcggcga ttggctccaa gagcgatatg agatcgtggg gaacctgggt gaaggcacct
      541 ttggcaaggt ggtggagtgc ttggaccatg ccagagggaa gtcacaggtt gccctgaaga
      601 tcatccgtaa tgtgggcaag taccgggaag ctgctcgtct agaaattaat gttctcaaga
      661 aaatcaagga gaaagacaaa gaaaataagt tcctttgtgt cctgatgtct gactggttca
      721 acttccatgg tcatatgtgt atcgcctttg agctcctggg caagaacacc tttgagttcc
      781 tgaaggagaa caacttccag ccttatcccc taccacatgt ccggcacatg gcctaccagc
      841 tctgtcatgc ccttagattt ctacatgaga accagctgac ccacacagac ttgaagccag
      901 agaacatctt gtttgtgaat tctgagtttg aaaccctcta caatgagcac aagagctgcg
      961 aggagaagtc agtgaagaac accagcatcc gagtggcaga ctttggcagt gccacatttg
     1021 accatgaaca tcacaccacc attgtcgcca cccggcatta ccgcccacct gaggtgatcc
     1081 ttgagctggg ctgggcacag ccctgtgatg tctggagtat cggctgcatt ctctttgagt
     1141 actaccgtgg ctttacactc ttccagaccc atgaaaacag agaacacttg gttatgatgg
     1201 agaagatcct aggacccatc ccatcacaca tgatccaccg taccaggaag cagaagtatt
     1261 tctacaaagg gggcctggtt tgggatgaga acagctctga cgggcggtat gtgaaggaga
     1321 actgcaaacc tctgaagagt tacatgctcc aggactccct ggagcatgtg cagctgtttg
     1381 acctgatgag gaggatgtta gagttcgacc ctgctcagcg catcacactg gcagaagctt
     1441 tgctgcaccc cttctttgct ggcctgaccc ctgaggagcg gtccttccac agcagccgta
     1501 accccagcag atgacaggtg caggccagca cacgaagagt tggagagctg gactgggctg
     1561 ctggcccctt ttctccagcc tctcctactg gcttcagagc cagagccacc gatgaacagt
     1621 gcaatgtgaa ggaaggcagg aacctgcaag ggattggggg tgtggtgccc agctgccaga
     1681 aagcacagat tggacccaag ctatttatat gttgtaaagt tataataaag tgtttcttac
     1741 tgtttgtaa
//
LOCUS       NM_001436452             778 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 3-like 1
            (Mbd3l1), transcript variant 2, mRNA.
ACCESSION   NM_001436452 XM_039080995
VERSION     NM_001436452.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 778)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_039080995.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1071000.1,
                                           SRR26360181.1516671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000008.1  24432245-24432288
            45-778              JAXUCZ010000008.1  24435954-24436687
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..778
                     /gene="Mbd3l1"
                     /note="methyl-CpG binding domain protein 3-like 1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
     exon            1..44
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..778
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    48..50
                     /gene="Mbd3l1"
                     /note="upstream in-frame stop codon"
     CDS             63..623
                     /gene="Mbd3l1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3-like 1"
                     /protein_id="NP_001423381.1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
                     /translation="MGKTSQRKQCDCENPSKPCLSTSIPLRMSNYTFKRPVTKITSHL
                     GNEVRYYQWEETLEKPEQACWQKRLQGLQAYSSAGEILSTSDLSKALKDLTPRDTDAA
                     SSIIQANSMDPRPLSTLGSSSHLAKMIPEAGPQILCKEFLVTEEDISIQERKVKIARE
                     RLAVALIAHKLANETEKVRGSRKAKV"
     misc_feature    87..284
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    87..284
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    294..560
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
     misc_feature    294..560
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
ORIGIN      
        1 gacaacatat gaaggttcta aatcatccag agagctggtt agagggctaa gaacggagtc
       61 agatgggcaa gacttcacag aggaagcaat gtgactgtga gaatccatca aagccttgtt
      121 taagtacctc aatccccctg aggatgtcta attatacatt caagaggcca gtcactaaaa
      181 tcacatccca tctgggcaat gaggtaagat actatcagtg ggaggagacc ttggagaagc
      241 cggagcaagc ctgctggcaa aagagacttc aaggactcca ggcctacagc agtgcgggag
      301 aaattttgag cacttcagac ctttccaagg ctttgaaaga tcttacacct agagacacag
      361 acgccgcctc ttcaatcatt caagctaaca gcatggaccc caggcccttg tccacccttg
      421 ggtcatcttc acatttggca aagatgatac cagaagcagg cccacagatc ctttgcaaag
      481 aatttctggt cactgaagag gatattagca tccaggaaag gaaagtgaaa atagcaagag
      541 aaagactggc agtggcattg attgcacaca agctagcaaa tgagacagag aaagtgaggg
      601 gttcaaggaa agcaaaggta taaacatgat ggggggaggg agtactgggg aaaagacact
      661 gcacgtgaaa tggggcatag ccttgtttta acgcctcttt gcagtcttta gttgttttga
      721 gaccttgaaa ctttaaactt aacaatactt tattaaaagt ctgtgcgatg caaaaaaa
//
LOCUS       NM_001436440            3898 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            transcript variant 11, mRNA.
ACCESSION   NM_001436440 XM_063266248
VERSION     NM_001436440.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3898)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3898)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3898)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3898)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3898)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3898)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3898)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3898)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3898)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3898)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063266248.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.432067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000008.1  28198637-28198780
            145-256             JAXUCZ010000008.1  28208228-28208339
            257-353             JAXUCZ010000008.1  28209003-28209099
            354-451             JAXUCZ010000008.1  28219161-28219258
            452-490             JAXUCZ010000008.1  28219581-28219619
            491-720             JAXUCZ010000008.1  28220002-28220231
            721-898             JAXUCZ010000008.1  28220683-28220860
            899-1046            JAXUCZ010000008.1  28223540-28223687
            1047-1138           JAXUCZ010000008.1  28224972-28225063
            1139-1234           JAXUCZ010000008.1  28225440-28225535
            1235-1346           JAXUCZ010000008.1  28226074-28226185
            1347-1444           JAXUCZ010000008.1  28226611-28226708
            1445-1556           JAXUCZ010000008.1  28227262-28227373
            1557-1667           JAXUCZ010000008.1  28227460-28227570
            1668-1867           JAXUCZ010000008.1  28228703-28228902
            1868-2035           JAXUCZ010000008.1  28229217-28229384
            2036-2158           JAXUCZ010000008.1  28230383-28230505
            2159-2335           JAXUCZ010000008.1  28230664-28230840
            2336-2492           JAXUCZ010000008.1  28230937-28231093
            2493-2546           JAXUCZ010000008.1  28231210-28231263
            2547-3898           JAXUCZ010000008.1  28231704-28233055
FEATURES             Location/Qualifiers
     source          1..3898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3898
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..144
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..256
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..353
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..451
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    413..415
                     /gene="Ilf3"
                     /note="upstream in-frame stop codon"
     CDS             449..2596
                     /gene="Ilf3"
                     /note="isoform 11 is encoded by transcript variant 11; M
                     phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform
                     11"
                     /protein_id="NP_001423369.1"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRRPMRIFVNDDRHVMAKHSSVYPTQEELEAV
                     QNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTL
                     RGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEIL
                     QSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLA
                     ALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTAN
                     RPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHA
                     LRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGE
                     EKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVE
                     VDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAP
                     PPVVEAVSNPSSVFPSDATTEGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKR
                     FVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGGP
                     KFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNAG
                     AGYGSYGYSSNSATAGYSDFFTDCYGYHDFGAS"
     misc_feature    749..1513
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    749..1513
                     /gene="Ilf3"
                     /note="domain in DSRM or ZnF_C2H2 domain containing
                     proteins; Region: DZF; smart00572"
                     /db_xref="CDD:128842"
     misc_feature    1679..1897
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    1679..1897
                     /gene="Ilf3"
                     /note="first double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt1; cd19910"
                     /db_xref="CDD:380739"
     misc_feature    order(1694..1696,1703..1708,1715..1720,1724..1726,
                     1766..1771,1775..1777,1781..1783,1832..1840,1847..1849)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    order(1694..1696,1703..1708,1715..1720,1724..1726,
                     1766..1771,1775..1777,1781..1783,1832..1840,1847..1849)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380739"
     misc_feature    2042..2257
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    2042..2257
                     /gene="Ilf3"
                     /note="second double-stranded RNA binding motif of
                     interleukin enhancer-binding factor 3 (ILF3) and similar
                     proteins; Region: DSRM_ILF3_rpt2; cd19912"
                     /db_xref="CDD:380741"
     misc_feature    order(2063..2065,2069..2074,2081..2083,2120..2122,
                     2129..2137,2147..2149,2195..2206)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     misc_feature    order(2063..2065,2069..2074,2081..2083,2120..2122,
                     2129..2137,2147..2149,2195..2206)
                     /gene="Ilf3"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380741"
     exon            452..490
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..720
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..898
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1138
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1234
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1346
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1444
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1556
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1667
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1867
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2035
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2158
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2335
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2492
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2546
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..3898
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcgc cattgcagtt gggactgaag cagccccggc gaaaaccgcg tggctctttt
       61 tttgaagggg gttgtgaaga ctccggaagg ctggtggcag gagggtggcg gcggcgcctg
      121 aggacgaagg acgggaacgc caaggattcc gttctgatgt taacaatgct gacacagcac
      181 tggcagtgcg tttcacttgt aggattctca ccagtttgct gaagactact ttcagcacct
      241 ccagaaatgt gaaaaggaga acagaagagg gtgtcggcct tcttgggaca gatgattgta
      301 agctgcatgt gggtgccagg aactgaaccc tggttcctct gcaagagcag taaatagttg
      361 aagtattggt aacaccaagg aactgtcaca atttgaaaag ataagccaag gctgatttcc
      421 agacactaca ggaaaaaagg aggggaaaat ggcattgtat catcatcact tcatcacaag
      481 aagaagaagg cgtcccatga gaatttttgt gaatgatgat cgccatgtga tggcaaagca
      541 ttcttcagta tacccaacac aagaggagct ggaggctgta cagaacatgg tgtcccacac
      601 tgagcgggcc ctcaaggctg tctctgactg gattgatgag caggagaaag gcaacagcga
      661 gctctctgaa gcagaaaata tggacacacc cccagatgat gagagcaaag aaggggctgg
      721 ggaacagaag gcggaacaca tgactaggac cctgaggggc gtgatgcggg tcggcctggt
      781 agccaagggt cttctgctca agggggactt ggatctggag ctggttctgc tctgtaagga
      841 gaagcccaca actgcccttc tggacaaggt ggctgacaac ctggccatcc agcttactac
      901 tgtaacagaa gacaagtatg aaatactcca atctgtggat gatgctgcga ttgtgataaa
      961 aaacacaaaa gagcccccct tgtccttgac catccatctg acctcccctg ttgtcagaga
     1021 agaaatggag aaagtattag ctggagaaac gctatcagtc aacgaccccc cggacgttct
     1081 ggacaggcag aaatgccttg ctgccttggc gtccctccga cacgccaagt ggttccaggc
     1141 tagagccaat gggctgaagt catgtgtcat tgtcatccgt gtcctaaggg acttgtgtac
     1201 ccgagtgccc acctggggtc ctctcagagg atggcctctg gagctgctgt gtgagaagtc
     1261 catcggcact gccaataggc caatgggtgc tggtgaagcc ctgcggagag tactggagtg
     1321 cctggcttcc ggcatcgtaa tgccagatgg ttctggcatt tatgaccctt gtgaaaaaga
     1381 agccactgat gctattgggc atctagacag acagcaacgg gaagatatca cacagagtgc
     1441 gcagcatgct ctgcggcttg ctgcctttgg ccagctccat aaagtactgg gaatggaccc
     1501 actgccttcc aaaatgccca agaaaccaaa gaacgagaac ccggtggact atactgttca
     1561 aatccccccc agcaccacct acgccatcac acccatgaaa cgccctatgg aagaagatgg
     1621 ggaggagaag tctcccagca aaaagaaaaa gaagatccag aagaaagagg agaaggctga
     1681 gcctccccaa gctatgaatg ccctgatgag gttaaaccag ctgaagccag ggctacagta
     1741 caagctgatc tcccagacgg gtcctgttca cgctcccatc ttcaccatgt ctgtggaggt
     1801 agacggcagt acctttgagg cctcagggcc atctaaaaag accgccaagc tacatgtggc
     1861 tgtgaaggtg ttacaggaca tgggattgcc aacaggcgct gaaggcagag actccagcaa
     1921 gggggaggac tctgctgagg agtcagatgg gaagccagca gtagtggccc caccccctgt
     1981 ggtggaagca gtctccaacc ccagttctgt cttcccttca gatgccacta ctgaggggcc
     2041 gattttgact aagcacggca agaatcctgt aatggagctt aatgagaaga gacgtggcct
     2101 caaatatgag ctcatttctg agacaggggg cagccacgac aaacggtttg ttatggaggt
     2161 tgaggtggac ggacagaagt ttcaaggtgc tggctcaaac aaaaaggtag caaaggctta
     2221 tgctgcactt gccgcattag agaagctttt ccctgacgcc cctcttgctc ttgaagccaa
     2281 caagaagaaa agagcccctg tgcctgtccg aggcggaccc aaatttgctg ccaagccaca
     2341 taaccctggc tttggcatgg gaggccccat gcataatgaa gcgcccccac ctcccaacat
     2401 ccgaggtcgg ggccgaggag gtaacatccg agggcgagga cgggggcgag gatttggtgg
     2461 caccaaccac ggaggaggct acatgaatgc tggcgctgga tatggaagct atgggtacag
     2521 cagcaattcg gccacagcag gctacagtga ctttttcaca gactgctacg gctatcatga
     2581 ttttggggct tcctagagcg tctaaaagta ttgacacaaa atcaactttt tactccaatt
     2641 tcctccaact ccaaaaccca aagtgtccgt gctgtgtccc tgtgcttcac tggggttctc
     2701 aaccgtggct ttccaccgca gcctgtctga aactgttagc ctgcagactt aagacaatgg
     2761 cagtttctat catgagtttg cctttgaact tggtcatttc gaagttcaca ctaagtggaa
     2821 aaaccctttt ctcagagaat ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2881 gtgtgtagcc ttgcacagaa ttctagagcc agcgttgttc agcatcaagg caaaagccca
     2941 tcattgcttt ttatggaaag cattctttta tttaaagaaa cagataatgg cacgttttaa
     3001 tctacctttg tcttaattta cagcaggttt tgtatgcaat ttttaacctt ttcacaagtt
     3061 ttcacatctg gttgatgcct ttggcagtga tgaaaacttt cagcacatct gaatccacag
     3121 cagctgactt ttttccttgc cttttgaatg agcatgtaaa cctctgggat ggccagaact
     3181 tgtgtactgc gtagagcagg gcctcccacc ttttgtaaat gctctggtgg gtccttgggg
     3241 tgaggaggtt ctgtggctgc tttagttaag agagtgaact tgcaaaggca tcaaaactgc
     3301 gcttccgtta cttgtgtgag aaatgagaca ggcttgagag gagggaataa cgtaaaattt
     3361 tgcaagtcct gattgcagcg tggactcctg gattgggttt ggctttgttt tctttttcac
     3421 aatggggctt taaaactgag ctggaggagc ctgacacatc ccaccctttt tttcccccag
     3481 caaattgctg actttggccc gaccagggtc tatactgcct ggcacacaga cactgaatct
     3541 gtgtgcctag aatttgtccc agtgtgtaaa gtggtgggga gccttgtgat attgtggtta
     3601 ggcctctgct ttgtagtttt tgctgcagat ttgcccctgc cttgacttgc aagatttgac
     3661 gtttattcag gcaaaaagtg gtcaaaatgg ttactgtgtg atttgttccc caaggtttaa
     3721 aaagtcagtg aaactttcta agattttgca tgatgtattt tattttattt ttatttttta
     3781 gaaagttctt gttggcaaat aatgtctttt tataccagga aatagttctg aatgacgttg
     3841 aagaccttcc cttccttatt actattattt tttaaatgaa tacatgttaa agtaatga
//
LOCUS       NM_001436449            1844 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus CDC-like kinase 3 (Clk3), mRNA.
ACCESSION   NM_001436449 XM_063264827
VERSION     NM_001436449.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Ma,X., Gao,L., Ge,R., Yuan,T., Lin,B. and Zhen,L.
  TITLE     CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 333-342 (2024)
   PUBMED   38438604
  REMARK    GeneRIF: CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway.
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Duncan,P.I., Stojdl,D.F., Marius,R.M., Scheit,K.H. and Bell,J.C.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Becker,W., Kentrup,H., Heukelbach,J. and Joost,H.G.
  TITLE     cDNA cloning and characterization of rat Clk3, a LAMMER kinase
            predominately expressed in testis
  JOURNAL   Biochim Biophys Acta 1312 (1), 63-67 (1996)
   PUBMED   8679717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063264827.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3009444.1,
                                           SRR26360181.1155481.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000008.1  67062138-67062273   c
            137-288             JAXUCZ010000008.1  67058757-67058908   c
            289-505             JAXUCZ010000008.1  67057799-67058015   c
            506-602             JAXUCZ010000008.1  67055507-67055603   c
            603-669             JAXUCZ010000008.1  67055164-67055230   c
            670-786             JAXUCZ010000008.1  67052689-67052805   c
            787-953             JAXUCZ010000008.1  67051925-67052091   c
            954-1048            JAXUCZ010000008.1  67050871-67050965   c
            1049-1178           JAXUCZ010000008.1  67050644-67050773   c
            1179-1261           JAXUCZ010000008.1  67050006-67050088   c
            1262-1341           JAXUCZ010000008.1  67049514-67049593   c
            1342-1432           JAXUCZ010000008.1  67049175-67049265   c
            1433-1844           JAXUCZ010000008.1  67048121-67048532   c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1844
                     /gene="Clk3"
                     /note="CDC-like kinase 3"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
     exon            1..136
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1609
                     /gene="Clk3"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3"
                     /protein_id="NP_001423378.1"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR"
     misc_feature    137..550
                     /gene="Clk3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63117.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    155..157
                     /gene="Clk3"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    161..163
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    281..283
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    287..289
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    335..337
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    362..364
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    368..370
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    539..541
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    560..1552
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    560..1552
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    order(620..634,644..646,686..688,692..694,734..736,
                     794..796,842..853,860..862,866..871,983..985,989..991,
                     995..1000,1004..1006,1094..1096,1103..1105,1130..1132,
                     1136..1147,1151..1153,1262..1264)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(620..634,644..646,686..688,692..694,734..736,
                     794..796,842..853,860..862,866..871,983..985,989..991,
                     995..1000,1004..1006,1094..1096,1103..1105,1130..1132,
                     1136..1147,1151..1153,1262..1264)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(620..631,644..646,686..688,692..694,794..796,
                     842..853,860..862,869..871,995..1000,1004..1006,
                     1091..1096)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(620..631,644..646,686..688,692..694,794..796,
                     842..853,860..862,869..871,995..1000,1004..1006,
                     1091..1096)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(734..736,866..868,983..985,989..991,1103..1105,
                     1130..1132,1136..1147,1151..1153,1262..1264)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(734..736,866..868,983..985,989..991,1103..1105,
                     1130..1132,1136..1147,1151..1153,1262..1264)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    1091..1153
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     misc_feature    1091..1153
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     exon            137..288
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..505
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..602
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..669
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..786
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..953
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1048
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1178
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1261
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1341
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1432
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1844
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggagtg gggcctagcc gcagccggag cctgggagac ggtgagtgtg ggcctgggcc
       61 cacggccggg cagctggggt cagtcagtgg ggacagccaa gctggtacgg gtaccttggc
      121 actcggtcgg gtctcgatgc atcactgtaa gcgataccgt tccccagagc cagacccata
      181 cctgagctac cgctggaaga ggaggcggtc ttacagtcgg gagcatgaag gtcgactacg
      241 atacccatcc cgaagggagc ctcccccacg gagatcaagg tccagaagcc atgatcgtat
      301 accctaccag aggaggtacc gggaacaccg agacagcgat acatatcggt gtgaagagcg
      361 gagcccatcc tttggagagg actgctatgg gtcttcacgt tctcgacatc ggagacggtc
      421 acgagagagg gggccgtacc gtacccgcaa gcatgcccac cactgtcaca aacgtcgtac
      481 caggtcttgt agcagcgcct cctcgagaag ccaacagagc agtaagcgca gcagccggag
      541 tgtggaagat gacaaggagg gccacctggt gtgccggatc ggcgattggc tccaagagcg
      601 atatgagatc gtggggaacc tgggtgaagg cacctttggc aaggtggtgg agtgcttgga
      661 ccatgccaga gggaagtcac aggttgccct gaagatcatc cgtaatgtgg gcaagtaccg
      721 ggaagctgct cgtctagaaa ttaatgttct caagaaaatc aaggagaaag acaaagaaaa
      781 taagttcctt tgtgtcctga tgtctgactg gttcaacttc catggtcata tgtgtatcgc
      841 ctttgagctc ctgggcaaga acacctttga gttcctgaag gagaacaact tccagcctta
      901 tcccctacca catgtccggc acatggccta ccagctctgt catgccctta gatttctaca
      961 tgagaaccag ctgacccaca cagacttgaa gccagagaac atcttgtttg tgaattctga
     1021 gtttgaaacc ctctacaatg agcacaagag ctgcgaggag aagtcagtga agaacaccag
     1081 catccgagtg gcagactttg gcagtgccac atttgaccat gaacatcaca ccaccattgt
     1141 cgccacccgg cattaccgcc cacctgaggt gatccttgag ctgggctggg cacagccctg
     1201 tgatgtctgg agtatcggct gcattctctt tgagtactac cgtggcttta cactcttcca
     1261 gacccatgaa aacagagaac acttggttat gatggagaag atcctaggac ccatcccatc
     1321 acacatgatc caccgtacca ggaagcagaa gtatttctac aaagggggcc tggtttggga
     1381 tgagaacagc tctgacgggc ggtatgtgaa ggagaactgc aaacctctga agagttacat
     1441 gctccaggac tccctggagc atgtgcagct gtttgacctg atgaggagga tgttagagtt
     1501 cgaccctgct cagcgcatca cactggcaga agctttgctg caccccttct ttgctggcct
     1561 gacccctgag gagcggtcct tccacagcag ccgtaacccc agcagatgac aggtgcaggc
     1621 cagcacacga agagttggag agctggactg ggctgctggc cccttttctc cagcctctcc
     1681 tactggcttc agagccagag ccaccgatga acagtgcaat gtgaaggaag gcaggaacct
     1741 gcaagggatt gggggtgtgg tgcccagctg ccagaaagca cagattggac ccaagctatt
     1801 tatatgttgt aaagttataa taaagtgttt cttactgttt gtaa
//
LOCUS       NR_199174               2590 bp    RNA     linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 49 (Lrrc49),
            transcript variant 5, non-coding RNA.
ACCESSION   NR_199174 XM_063265150
VERSION     NR_199174.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063265150.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211943.1, SRR26360176.1892879.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000008.1  70056247-70056481   c
            236-292             JAXUCZ010000008.1  70055581-70055637   c
            293-380             JAXUCZ010000008.1  70053406-70053493   c
            381-584             JAXUCZ010000008.1  70045578-70045781   c
            585-651             JAXUCZ010000008.1  70039865-70039931   c
            652-795             JAXUCZ010000008.1  70037281-70037424   c
            796-857             JAXUCZ010000008.1  70019484-70019545   c
            858-1005            JAXUCZ010000008.1  69996747-69996894   c
            1006-1089           JAXUCZ010000008.1  69984849-69984932   c
            1090-1253           JAXUCZ010000008.1  69980873-69981036   c
            1254-1491           JAXUCZ010000008.1  69965190-69965427   c
            1492-1677           JAXUCZ010000008.1  69963925-69964110   c
            1678-1787           JAXUCZ010000008.1  69959742-69959851   c
            1788-1941           JAXUCZ010000008.1  69954547-69954700   c
            1942-2590           JAXUCZ010000008.1  69948964-69949612   c
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2590
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     misc_RNA        1..2590
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /product="leucine rich repeat containing 49, transcript
                     variant 5"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     exon            1..235
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    188..391
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001134469.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            236..292
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            293..380
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            381..584
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            585..651
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            652..795
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            796..857
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1005
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1089
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1253
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1491
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1677
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1787
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1941
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2590
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagataatc cctgaggcta gccacccgga cggcccacag atctggggcg aggaccagac
       61 cggaaatggt ggtttctatg gtaacccctg aacaggttgc ctgggagatg accccttttg
      121 gtctctttga atcttagctg ttgcattacc tcgaaggagg atcgaacatc ctggactgtt
      181 tcctgccatg attcccggga aataccgctc cgtttctggc cgggctgcaa acaacgtgaa
      241 ctgtggactt catctggtta ttcaaacgtc gtcactttct gacaaaaaca aagttgaatt
      301 caagcttaat agagaaacac catcatttcc tggtagactg ttacagcatg acctggagag
      361 aaactactca agtagacaag acaaaagttg actgtgtgcc ctatcatcga cggggaggag
      421 caccttcgtt tgttgaactt tcagcacaat tttataactc ggatccaaaa tatttctaat
      481 ctacagaggc taatattctt ggacttatat gataaccaga ttgaagaaat tagtgggctt
      541 tccactctga aatcccttcg tgtcctcctg ttagggaaga acagaatcaa gaaaatctca
      601 aatctggaga atctaaaaaa tttagatgtc ttggaccttc atggaaatca gattaccaaa
      661 attgaaaatg ttaatcattt gtgtgacttg agagttttaa accttgccag gaacctcttg
      721 agtcatgttg acaatctcaa cggtctggat tcactaacag aacttaacct tcgccacaac
      781 cagatcacct tcgtgagaga tgtggataat ttgccctgcc tccaacgcct cttcctcagc
      841 ttcaacaata taactagctt tgaaagtgtt tcctgccttg ctgagtcaac ttccctctca
      901 gacatcacct ttgatggcaa tccaatagct caagagtcat ggtacaaaca cacggtcctt
      961 cagaatatga tgcagctgcg ccagctagac atgaagagaa tcacggaaga agaaagacgc
     1021 gtggcatctg ttgtggccaa aaaagaggag gagaagaaga gggagagtca caagcagtcc
     1081 ttgctgaagg agaagaaaag gttaacaatt aacaacgtcg ctcgaaagtg ggacttgcag
     1141 caacgagtag ccaatatcgc catcattcag gacagaaagg actctgagtc tcctcctcag
     1201 gaatcctgtc agatcgatgg aggcaccatc tccgcatttc ccgaggaagc agggtctcta
     1261 gatgcgggac tcagcagtgc gttacaaggc ttgtctgtca cagaaacaca cttggtggag
     1321 ctagatggag aaaccctgtc actgtatggc tcaggggcgc tggaatgcct agatcgtaac
     1381 tggagtgttc aaacagctgg catggtcacc accgtctcgt tcacattcat cgagtttgat
     1441 gaaattgtcc aagtacttcc caaactgaag atgaagtttc caaattctct gcaccttaag
     1501 ttcagggaga ccaaccttgt gatgctgcag cagttcaacg ccctcgcgca acttcgtcgg
     1561 gttgaccagt tgacaatcga tcctcaggga aacccagtgg tgaacttcac actctggaag
     1621 tactacgtgc tgtttaggct cagccacttc agcatgcaga aaataaatgg aacagaggtg
     1681 acacaaaatg acatgataat ggctgaaagg ctctttggaa tcttagcaca tgtggcatcc
     1741 tctgagctgc cccagtaccg catgatttca attctgggtg atgccaggaa aaagcagttc
     1801 cggtatctgc tggagaacaa atgtaaaaag cctggcatcc tctgtgagga gacgagtgac
     1861 agcaagagat taatggggga aaacacaaac cgagctaccc tgaattacac cacccgagaa
     1921 ttctaccacg agaagctgga ggaaataaag gacaagaaga agttctgcag gttgtatgta
     1981 gaagacctgg tgaaggaagc cacagccatc aacatgaaaa atgaggctct gcagaagctg
     2041 tggccacaga tgttcatcga gcttgtcagg gatgccgtca tagagatccg cagcaaggac
     2101 tcctacatga agctctgcct gcagcagatc actgaccaga aatagggatg gctcatgctt
     2161 cagacatggg caattggagc tgttttaaag ttgggcaaga tgcaggttag acatgatgag
     2221 acatcaccac ttccgcacat actagaaaga gcggcatcaa agcctcgccc cctgcactgt
     2281 tgaggaggag ggaggcagga gagaggggga ctctttccca cgcatgctga ccacacaacc
     2341 ttggggaccc gagcagcaac tggagaaggc ctggctgctg ggtcagaaat gcttcttcag
     2401 ctcctgctct gactggtgtg cctgcccccg tcccaggcac agtgcgtgct gatgggcaag
     2461 catgagacgc ctctaccaac ctccagctga gacttttctc ttattttgcc tttttatttt
     2521 atgtcatgat ttcaaagcca agcttatgtt cttttttatg agtgaaaaat aaatacatta
     2581 gtaaaaaaaa
//
LOCUS       NM_001106821            9756 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ATM serine/threonine kinase (Atm), mRNA.
ACCESSION   NM_001106821 XM_001068795 XM_236275
VERSION     NM_001106821.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9756)
  AUTHORS   He,T., You,M., Zhu,H., Chen,P. and Fang,S.
  TITLE     CCCTC-binding factor suppresses alpha-2-macroglobulin transcription
            to improve vascular endothelial cell functions in lower extremity
            arteriosclerosis obliterans
  JOURNAL   Gen Physiol Biophys 43 (3), 231-242 (2024)
   PUBMED   38774923
  REMARK    GeneRIF: CCCTC-binding factor suppresses alpha-2-macroglobulin
            transcription to improve vascular endothelial cell functions in
            lower extremity arteriosclerosis obliterans.
REFERENCE   2  (bases 1 to 9756)
  AUTHORS   Cho,S.O., Lim,J.W. and Kim,H.
  TITLE     Oxidative stress induces apoptosis via calpain- and
            caspase-3-mediated cleavage of ATM in pancreatic acinar cells
  JOURNAL   Free Radic Res 54 (11-12), 799-809 (2020)
   PUBMED   31401888
  REMARK    GeneRIF: Oxidative stress induces apoptosis via calpain- and
            caspase-3-mediated cleavage of ATM in pancreatic acinar cells.
REFERENCE   3  (bases 1 to 9756)
  AUTHORS   Uhlemeyer,C., Muller,N., Griess,K., Wessel,C., Schlegel,C.,
            Kuboth,J. and Belgardt,B.F.
  TITLE     ATM and P53 differentially regulate pancreatic beta cell survival
            in Ins1E cells
  JOURNAL   PLoS One 15 (8), e0237669 (2020)
   PUBMED   32810137
  REMARK    GeneRIF: ATM and P53 differentially regulate pancreatic beta cell
            survival in Ins1E cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9756)
  AUTHORS   Zhao,J., Nguyen,L.N.T., Nguyen,L.N., Dang,X., Cao,D., Khanal,S.,
            Schank,M., Thakuri,B.K.C., Ogbu,S.C., Morrison,Z.D., Wu,X.Y.,
            Li,Z., Zou,Y., El Gazzar,M., Ning,S., Wang,L., Moorman,J.P. and
            Yao,Z.Q.
  TITLE     ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and
            Premature T Cell Aging in HIV-Infected Individuals on
            Antiretroviral Therapy
  JOURNAL   Front Immunol 10, 2531 (2019)
   PUBMED   31781094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9756)
  AUTHORS   Warren,R., Domm,W., Yee,M., Campbell,A., Malone,J., Wright,T.,
            Mayer-Proschel,M. and O'Reilly,M.A.
  TITLE     Ataxia-telangiectasia mutated is required for the development of
            protective immune memory after influenza A virus infection
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 317 (5), L591-L601 (2019)
   PUBMED   31509427
REFERENCE   6  (bases 1 to 9756)
  AUTHORS   Hirao,A., Kong,Y.Y., Matsuoka,S., Wakeham,A., Ruland,J.,
            Yoshida,H., Liu,D., Elledge,S.J. and Mak,T.W.
  TITLE     DNA damage-induced activation of p53 by the checkpoint kinase Chk2
  JOURNAL   Science 287 (5459), 1824-1827 (2000)
   PUBMED   10710310
REFERENCE   7  (bases 1 to 9756)
  AUTHORS   Chong,M.J., Murray,M.R., Gosink,E.C., Russell,H.R., Srinivasan,A.,
            Kapsetaki,M., Korsmeyer,S.J. and McKinnon,P.J.
  TITLE     Atm and Bax cooperate in ionizing radiation-induced apoptosis in
            the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 889-894 (2000)
   PUBMED   10639175
REFERENCE   8  (bases 1 to 9756)
  AUTHORS   Tibbetts,R.S., Brumbaugh,K.M., Williams,J.M., Sarkaria,J.N.,
            Cliby,W.A., Shieh,S.Y., Taya,Y., Prives,C. and Abraham,R.T.
  TITLE     A role for ATR in the DNA damage-induced phosphorylation of p53
  JOURNAL   Genes Dev 13 (2), 152-157 (1999)
   PUBMED   9925639
REFERENCE   9  (bases 1 to 9756)
  AUTHORS   Canman,C.E., Lim,D.S., Cimprich,K.A., Taya,Y., Tamai,K.,
            Sakaguchi,K., Appella,E., Kastan,M.B. and Siliciano,J.D.
  TITLE     Activation of the ATM kinase by ionizing radiation and
            phosphorylation of p53
  JOURNAL   Science 281 (5383), 1677-1679 (1998)
   PUBMED   9733515
REFERENCE   10 (bases 1 to 9756)
  AUTHORS   Xu,Y., Ashley,T., Brainerd,E.E., Bronson,R.T., Meyn,M.S. and
            Baltimore,D.
  TITLE     Targeted disruption of ATM leads to growth retardation, chromosomal
            fragmentation during meiosis, immune defects, and thymic lymphoma
  JOURNAL   Genes Dev 10 (19), 2411-2422 (1996)
   PUBMED   8843194
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068795.1, XM_236275.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..9756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..9756
                     /gene="Atm"
                     /note="ATM serine/threonine kinase"
                     /db_xref="GeneID:300711"
                     /db_xref="RGD:1593265"
     exon            1..194
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            195..296
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    219..221
                     /gene="Atm"
                     /note="upstream in-frame stop codon"
     CDS             225..9419
                     /gene="Atm"
                     /EC_number="2.7.11.1"
                     /note="Ataxia telangiectasia gene mutated in human beings;
                     ataxia telangiectasia mutated homolog"
                     /codon_start=1
                     /product="serine-protein kinase ATM"
                     /protein_id="NP_001100291.1"
                     /db_xref="GeneID:300711"
                     /db_xref="RGD:1593265"
                     /translation="MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLD
                     RHSDSKQGKYLNWDAVFRFLQKYIQKETESLRTAKSNVSASTQTSRQKKMQEISSLVR
                     FFIKCANKRAPRLKCQDLLNYVMDTVKDSSNGATYGADCSNILLKDILSVRKYWCEVS
                     QQQWLELFSLYIRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQ
                     YARQEKSSPGLSHILAALNIFLKTLAVNFRKRVCEIGDEILPTLLYIWTQHRLNDSLK
                     EVIIELIHLQIYIHHPQGAKAPEEGAYESMKWKRILYNLYDLLVNEISHIGSRGKYSS
                     GSRNIAVKENLIDLMADVCYQLFNADTRSVEISQSYATQRESTDYSVPCKRRKIDIGW
                     EVIKDYLQKSQNDFDLVPWLQITTRLISKYPSSLPNCELSPLILILYQLLPQQRRGER
                     IPHVLRCLTEVALCQGKKSNLESSQKSDLLKLWIKIWSITFRGISSEQTQTENFGLLG
                     AIIQGSLVELDREFWKLFTGSACKPSSPSVRCLTLALSMCVVPDAIKMGTEQSVCDAN
                     RSFSVKESIMRWLLFYQLEGDLEDSAEPPPILQSNFPHLILEKILVSLTMKNSKAAMK
                     FFQSAPECEQHCEDTEEPSFSEAEELFLQTTFDKMDFLTPVKEDTVEKFQSRVGFSVH
                     QNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGVITEDEAY
                     KSELFQKAKSLMQCAGESISLFKNKTNEESRVGSLRSVIHLCTSCLCRHTKHTLNKIA
                     SGFFLRLLTSKLMNDIADICKSLASCTKKPFDYGEEHSLRDDDDDGDGGDGGESLMET
                     QGSSSTDLFSDYSASTVSDANDYGENQNAVGAANPLTADWLSRQDHLLLDMLRFLCLS
                     VTACQSRTASFRGADIRRKLLMLLDPSTLDLTKSLHLHMYLVLLKDLPGKEHLLPMED
                     VVELLQPLSLVCSLYRRDQDVCKTILSNVLHIVTNLGQGSVDTESTRNAQGQFLTVMG
                     AFWHLTKEKKCIFSVRMALVKCLQTLLEADPYSKWAILNVKGQDFPVREAFPQFLADG
                     HHHVRMLAAGSISRLFQDMRQGDSSRSLKALPLKFQQTSFNSAYMIAEAGIRELLCDS
                     QNPDLLDEIYNRKSVLLTVIAVVLHCSPICEKQALFALCKSVKENGLEPHLVKKVLEK
                     VSESFGCRCLEDFMASHLDYLVLEWLNLQDAKYSLSSFPFTLLNYMSVEDFYRSCYKI
                     LIPHLVIRKHFDEVKSIANQIQRCWKSLLIDCFPKMLVHILPYFACEGTGDSSSAQKR
                     ETATEVYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSDSGQSPDLCDFSG
                     DLDPAPNPPYFPSHVIKATFAYISSCHKTKFKSILEILSKIPDSYQKILLAICEQAAE
                     TNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDV
                     SLRSFSLCCDLLSRVCRTAVTHCKDALENHLHVIVGTLIPLVDYQEVQEQVLDLLKYL
                     VIDNKDNKNLFVTIKLLDPFPDHVVFKDLRLTQQKIKYSGGPFTLLEEINHFLSVSAY
                     NPLPLTRLEGLKDLRRQLEQHKDQMLDLVRASQDNPQDGIVVKLVVSLLQLSKMAVNQ
                     TGEREVLEAVGRCLGEIGPLDFSTIAVQHSKDTPYTKAYGLPEDRELQWTLIMLTALN
                     NTLVEDSVKIRSAAATCLKNILATKTGHIFWENHKTSADPMLTYLQPFRASRKKFLEL
                     PQFVKEDALEGLDDVNLWVPQSESHDIWIKTLTCAFLDSGGIKSEILQLLKPMCEVKT
                     DFCQMVLPYLIHDVLLQDTHESWRTLLSTHVRGFFTNCFKHSSQASRSATPANSDSES
                     ENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFEDAFWLDLNYLEVAKVAQSCAAH
                     FTALLYAEIYSDKKNMDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIY
                     RSIGEPDSLYGCGGGKVLQPLTRIRTYEHEATWEKALVTYDLETTISSSTRQSGIIQA
                     LQNLGLSHILSIYLKGLDHERREWCGELQELHYQAAWRNMQWDLCTSANQELEGTSYH
                     ESLYNALQCLRNREFSTFYDSLRHARVKEVEELSKGSLESVYSLYPTLSRLQAVGELE
                     NSGELFSRSVTDRERSEVYLKWQKHSQLLKDSDFSFQEPLMALRTVILEILVQKEMEN
                     SQGGCSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNPAICGISEWHLEEAQVF
                     WAKKEQSLALSILKQMIKKLDSSFREVCNEAGLKGLHAECLRVCGNWLAETCLENPAV
                     IMQTYLEKAVKVAGSYDGDSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQ
                     ALLKRAKEEVGLIREHKIQTNRYTIKVQRELELDECALRALKEDRKRFLCKAVENYIS
                     CLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKRDGMKISSYKFLPLMYQLAARMGTK
                     MTGGLGFHEVLNNLISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAP
                     KESSQLDEDRAEAASRIIHTIRSARRTMVKDMEALCDAYIILANLDASQWRNQRKGIS
                     IPANQPITKLKNLEDVVVPTMEIKVDPTGEYEKLVTIKSFKTEFRLAGGLNLPKIIDC
                     VGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNMLLQRNTETRKRKLTICTYKVVPLSQ
                     RSGVLEWCTGTIPIGEYLVNNEEGAHKRYRPNDLSANQCQKKMMEVQKKSFEEKYETF
                     MTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI
                     NEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTME
                     VMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETDLQSTPSADDQECKRS
                     LSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGW
                     KAWV"
     misc_feature    246..719
                     /gene="Atm"
                     /note="Telomere-length maintenance and DNA damage repair;
                     Region: TAN; pfam11640"
                     /db_xref="CDD:463317"
     misc_feature    246..719
                     /gene="Atm"
                     /note="Telomere-length maintenance and DNA damage repair;
                     Region: TAN; pfam11640"
                     /db_xref="CDD:463317"
     misc_feature    6531..7715
                     /gene="Atm"
                     /note="FAT domain; Region: FAT; pfam02259"
                     /db_xref="CDD:396714"
     misc_feature    6531..7715
                     /gene="Atm"
                     /note="FAT domain; Region: FAT; pfam02259"
                     /db_xref="CDD:396714"
     misc_feature    8295..9134
                     /gene="Atm"
                     /note="Catalytic domain of Ataxia Telangiectasia Mutated;
                     Region: PIKKc_ATM; cd05171"
                     /db_xref="CDD:270715"
     misc_feature    8295..9134
                     /gene="Atm"
                     /note="Catalytic domain of Ataxia Telangiectasia Mutated;
                     Region: PIKKc_ATM; cd05171"
                     /db_xref="CDD:270715"
     misc_feature    order(8325..8327,8331..8339,8343..8345,8391..8393,
                     8397..8399,8406..8408,8511..8513,8547..8558,8571..8573,
                     8871..8873,8877..8879,8910..8915)
                     /gene="Atm"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270715"
     misc_feature    order(8325..8327,8331..8339,8343..8345,8391..8393,
                     8397..8399,8406..8408,8511..8513,8547..8558,8571..8573,
                     8871..8873,8877..8879,8910..8915)
                     /gene="Atm"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270715"
     misc_feature    8847..8873
                     /gene="Atm"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270715"
     misc_feature    8847..8873
                     /gene="Atm"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270715"
     misc_feature    8913..8981
                     /gene="Atm"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270715"
     misc_feature    8913..8981
                     /gene="Atm"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270715"
     misc_feature    9324..9413
                     /gene="Atm"
                     /note="FATC domain; Region: FATC; pfam02260"
                     /db_xref="CDD:460514"
     misc_feature    9324..9413
                     /gene="Atm"
                     /note="FATC domain; Region: FATC; pfam02260"
                     /db_xref="CDD:460514"
     exon            297..409
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            410..555
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            556..720
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            721..886
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1125
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1289
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1456
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1828
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2023
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2119
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2345
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2471
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2597
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2687
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2883
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3083
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3166
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3322
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3398
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3529
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3650
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3824
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3994
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4241
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4357
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4484
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4684
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4856
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5021
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5154
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5250
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5422
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5564
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..5741
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5742..5919
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6007
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6163
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6164..6251
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6252..6340
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6341..6443
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6444..6592
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6593..6697
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6698..6817
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6818..7052
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7226
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7227..7340
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7341..7555
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7556..7763
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7764..7877
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7878..8036
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8037..8175
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8176..8258
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8259..8399
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8400..8516
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8517..8666
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8667..8832
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8833..8919
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8920..9034
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9035..9098
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9099..9235
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9236..9756
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgtcacc ttaagggttc tcgtcgacct aggagatttt ttttttatct cacactttag
       61 tctcagaccg tttatttcta tttaagctac aggtttgcat ttgttcgtag ttaagagcac
      121 tggctaggaa atcacagcct cgagagttcg aattcttatt gccagttgta ttacctgtgc
      181 tgtcttttag tgaggtgagg atgcacgttc tgaaatccta aaccatgagt ctagcgctga
      241 atgacctgct catctgctgc cggcagttag aacatgacag ggctacagaa cgaaggaaag
      301 aagtggataa atttaagcgc ctgattcagg atcctgaaac agttcaacat ttggataggc
      361 attctgactc caaacaaggg aaatatctga attgggatgc tgttttcagg tttttgcaga
      421 agtacattca aaaggaaaca gaaagtctta gaacagcaaa atcaaatgtc tcagcctcta
      481 cacaaacctc cagacagaag aagatgcaag agattagcag tctggtcaga ttcttcatca
      541 aatgtgcaaa taaaagagca cccaggctaa aatgtcagga cctcttgaat tacgtcatgg
      601 atacagtgaa agactcatct aatggcgcaa cttacggagc tgactgcagc aacattcttc
      661 tcaaagacat cctgtctgtg aggaaatact ggtgtgaagt gtctcagcag cagtggctag
      721 aattgttttc cctgtacatc aggctgtatc tcaaaccatc acaggacatt aatagagttt
      781 tagtggctag aataattcat gctgtcacca gaggatgctg ctcacagact gatggattac
      841 cttcaaagtt cttagatctt ttttccaagg ctattcagta tgccagacag gaaaagagct
      901 ctcctggctt aagtcacatc ttagcagccc ttaacatttt cctcaagact ttggctgtca
      961 acttccgaaa gcgggtgtgt gaaataggag atgaaattct tcctacctta ctgtatattt
     1021 ggactcaaca tcgacttaat gactccttaa aagaagtaat tattgaacta attcacctgc
     1081 agatttacat ccatcatcca cagggagcca aagcgcctga ggaaggtgct tatgaatcca
     1141 tgaaatggaa aaggatcttg tacaacttat acgacctgct ggtgaatgag ataagtcaca
     1201 taggaagcag agggaaatac tcctcaggat ctcgtaatat tgctgtcaag gaaaatttga
     1261 ttgacttgat ggcagatgtc tgttaccagc tttttaatgc agataccaga tccgtggaga
     1321 tttctcagtc ttatgcgaca caaagggaat ccactgacta cagtgtacct tgcaaaagaa
     1381 ggaaaataga cataggctgg gaagtgataa aagattatct tcagaagtca cagaatgatt
     1441 ttgatcttgt gccatggcta cagattacaa cccgattaat atcaaaatat ccttccagtt
     1501 tgcctaactg tgagctgtct ccattaatac tgatcctgta ccagcttctg cctcaacagc
     1561 ggcgtggaga acgcatccca catgtgttac gatgccttac cgaagttgcc ttatgtcaag
     1621 gcaagaaatc aaacctagaa agctctcaaa agtcagattt attgaaacta tggattaaaa
     1681 tttggtctat tacctttcgt ggtataagtt ctgaacaaac acaaactgaa aactttggtt
     1741 tacttggggc cattattcaa ggtagtttag ttgaacttga cagagaattc tggaagttat
     1801 ttactggctc agcctgtaaa ccttcaagtc cttcagttcg ctgcttgact ttggcgctta
     1861 gcatgtgtgt agttccagat gcaataaaaa tgggaacaga acaaagtgtg tgtgacgcaa
     1921 atagaagttt ttctgtgaag gagtcgataa tgaggtggct cttattctac cagttagagg
     1981 gcgacttgga agacagcgca gagccgcctc ccattctcca gagtaatttc cctcatctca
     2041 tactggaaaa aattcttgta agtctcacta tgaaaaactc aaaagctgca atgaagtttt
     2101 ttcaaagtgc cccagaatgt gagcagcact gtgaagatac agaagagcct tcgttctcag
     2161 aagcggaaga actgtttctc cagacaactt ttgacaagat ggatttttta actcctgtca
     2221 aagaagatac tgtagaaaaa tttcaatctc gtgttggctt ctctgtccac caaaatctca
     2281 aggaatcact ggatcattat cttctgggat tatcagaaca gcttttaagt aattactctt
     2341 ctgagattac aagttcagaa acccttgtcc ggtgttcgag tcttctggtg ggtgttcttg
     2401 gctgctattg ttacatgggt gtaataactg aagacgaagc atataaatca gaattattcc
     2461 agaaagccaa gtctctgatg cagtgtgcag gggaaagtat ctctttgttt aaaaataaga
     2521 caaatgagga gtccagagtt ggttcactga gaagtgtgat acatctgtgt acaagttgct
     2581 tgtgtagaca taccaagcac actctaaaca agatagcctc tggctttttc ctgcgattat
     2641 taacgtccaa gctcatgaat gacattgcag atatttgtaa aagcttggca tcctgtacga
     2701 aaaagccatt tgactatgga gaggagcatt cgttgagaga tgatgatgat gatggtgatg
     2761 gtggtgatgg tggtgaaagt ctgatggaga cacagggttc atcatccaca gatctattta
     2821 gcgattactc tgctagtact gtgagcgatg caaacgatta tggagagaac cagaatgctg
     2881 ttggtgccgc gaatcctcta actgctgact ggctgtccag acaagatcat cttcttttag
     2941 acatgctcag gttcttgtgc ctctctgtaa ctgcatgtca gagccggact gcgtctttca
     3001 gaggagctga tattagaaga aagttgttaa tgttactcga tcctagcaca ctcgatctca
     3061 ctaaatccct acacctacac atgtacttgg tgcttttgaa ggatctccct ggaaaagagc
     3121 atttgttgcc aatggaagat gttgttgaac ttctgcagcc attatccctt gtatgttctc
     3181 tgtatcggcg tgaccaagat gtctgcaaga cgattttaag caatgtcctc catatagtga
     3241 caaacctagg tcagggcagc gtggacacag agagcacaag gaatgctcaa ggacagttcc
     3301 tgacagtgat gggagcattt tggcatttaa caaaggaaaa gaaatgtata ttctctgtca
     3361 gaatggcgtt agtaaagtgt cttcaaacac tgcttgaggc tgatccatat tccaagtggg
     3421 cgattcttaa tgtaaaggga caggactttc ctgtacgtga agcatttcca cagtttcttg
     3481 ctgacggtca ccatcacgtt cggatgttgg ctgcggggtc gatcagcaga ttattccagg
     3541 atatgagaca aggtgattcc tccagaagct tgaaagcact tcctctgaag tttcagcaga
     3601 catctttcaa cagtgcatac atgatagcag aggcaggaat cagagaactg ttatgtgatt
     3661 ctcagaaccc tgatcttctg gatgagattt ataatagaaa atccgtattg ctgacggtga
     3721 tagctgtggt cttgcactgt agcccaatct gtgaaaagca ggctttgttt gccttatgca
     3781 aatctgtgaa ggaaaatgga ctagaacccc atcttgtgaa aaaggttttg gagaaagtct
     3841 ccgagtcgtt tggatgtagg tgcttagagg acttcatggc ttctcatcta gattacttgg
     3901 ttttggaatg gctgaacctt caagatgcta aatacagctt atcttccttt ccttttacgt
     3961 tattaaacta catgagcgtg gaggatttct atagatcttg ttacaagatt ctgattccac
     4021 acttggtaat tagaaagcac tttgatgagg tgaagtccat tgctaatcag attcagaggt
     4081 gctggaaaag cctgctgatc gactgctttc caaagatgct tgtgcacatc cttccgtact
     4141 ttgcctgtga gggcacgggg gacagcagct cggcacagaa gagggagact gctaccgagg
     4201 tctacgatac tcttaaaggt gaagacttcc taggaaaaca gattgatcaa gtattcatta
     4261 gtaatttgcc agagatcgtg gtggagctgc ttatgacgtt gcatgaaacg gctgactcgg
     4321 attccggtca aagccccgac ctctgcgatt tttcagggga tttggatccc gctcccaatc
     4381 caccatattt cccgtcacat gtcattaagg caacatttgc ctacatcagc agctgtcata
     4441 aaaccaagtt taaaagcatt ctagaaatcc tttctaaaat ccctgattcc tatcagaaaa
     4501 tactcctggc catttgtgaa caagcagctg agacaaataa tgtctttaaa aagcacagaa
     4561 ttcttaaaat ataccacctg tttgttagtt tattactgaa agacatacag agtggcttgg
     4621 gaggagcttg ggcctttgtt ctccgagatg ttatttatac tttgattcac tatatcaaca
     4681 aaaggtcttc ccatttcact gacgtgtcat tacgtagctt ctccctgtgc tgtgacctat
     4741 taagtcgagt ttgccgtaca gcggtaactc actgtaagga cgccctagaa aaccatcttc
     4801 atgttattgt gggcacactt ataccccttg tggattatca ggaggttcaa gaacaggtat
     4861 tggacctgtt gaagtacttg gtgatagata acaaagacaa taaaaacctc tttgtcacaa
     4921 ttaagcttct ggatccgttt cctgaccatg ttgtttttaa ggatttgcgt cttactcaac
     4981 agaagataaa atatagtgga ggacccttta cactcttaga ggaaataaac cattttctct
     5041 cagtaagtgc ttataatcca cttccactga ccagactcga aggactgaag gatcttcgga
     5101 gacaactgga acagcataaa gatcagatgc tagatcttgt gagagcatct caggataacc
     5161 cacaagatgg cattgtggtg aagctggttg tcagcttgtt gcagctatcc aagatggcag
     5221 tgaaccagac tggtgaaaga gaagttttag aggctgtcgg caggtgtttg ggagaaatcg
     5281 gtcctctgga tttctctact atagctgtac agcatagcaa agatacgccg tacaccaaag
     5341 cctacgggtt acctgaagac agagaacttc agtggacctt gataatgctg actgccctga
     5401 acaacaccct ggtggaggac agtgtcaaaa ttcgatcagc tgctgctacc tgtttgaaaa
     5461 acattttggc taccaagacc ggacatattt tctgggagaa tcataagaca tcagcggatc
     5521 caatgctgac ctatctgcag cctttcagag cgtcgaggaa aaagttttta gaattacccc
     5581 agtttgttaa agaagatgct ttagaaggcc tggatgatgt aaatctgtgg gttcctcaaa
     5641 gtgaaagcca tgacatttgg ataaagactc tgacttgtgc ctttttggac agtggaggca
     5701 taaaaagcga aattcttcag ttactaaagc caatgtgtga agtgaaaact gacttttgtc
     5761 agatggtgct gccatacttg atccatgatg ttttactcca agatacacat gagtcgtgga
     5821 gaactctgct atctacacac gtccgaggat ttttcactaa ctgttttaaa cattcctccc
     5881 aagcaagccg ctcagcgact cccgcaaatt cggattcaga gtcagagaac tttctccgat
     5941 gctgtttgga taaaaaatca caaagaacca tgctcgctgt tgtcgactac ctgagaaggc
     6001 aaaagaggcc ttcctcagga acagctttcg aggatgcctt ctggctagat ttgaattatc
     6061 ttgaggttgc aaaggtggct caatcctgtg cagctcactt cacagcactg ctctatgcag
     6121 agatctattc agataagaaa aacatggatg agcaagagaa aagaagtcca acatttgaag
     6181 aaggaagtca aggtacaact atttctagtt tgagtgaaaa aagtaaagaa gaaactggaa
     6241 taagcttaca ggatcttctc ttggagatct acagaagtat aggagagcca gacagcctgt
     6301 atggctgcgg gggagggaaa gtgttacaac cccttacccg aataaggacg tacgagcatg
     6361 aagcaacgtg ggagaaagcc ttagtgacat acgaccttga gaccaccatc tcctcctcca
     6421 cccgccagtc gggaatcatc caggccttgc agaacttggg gctctcccat attctttcta
     6481 tctacttgaa aggattggac catgaaagga gagagtggtg tggggaactg caggagcttc
     6541 attaccaggc ggcgtggagg aacatgcagt gggacctctg cacttctgcc aaccaagaac
     6601 tagaaggaac cagttaccac gaatcgttgt ataatgctct gcagtgccta agaaacagag
     6661 aattctccac attttatgac agtctccgac atgccagggt gaaggaagtt gaagagttga
     6721 gcaaaggcag ccttgaatcg gtatattcgc tgtaccccac acttagcaga ttgcaggcag
     6781 tcggagaact ggaaaacagt ggagagctct tctcaaggtc agtcacagac agagagcgct
     6841 ctgaggtata cctgaagtgg cagaagcact cccagcttct gaaggacagt gacttcagct
     6901 ttcaggagcc tctcatggct ctccgcacag tcattctgga gatcctggta caaaaggaaa
     6961 tggagaactc tcaaggagga tgctctaagg acattctcac caaacacctt gttgaattct
     7021 ctgttctggc ccgaaccttc aagaatacac agctccctga aagagcaata tttaaaatta
     7081 agcaatataa tccagctatt tgcggaatct ctgaatggca tttggaagaa gcacaagtat
     7141 tttgggcaaa gaaggagcag agtcttgccc tgagtatcct caagcaaatg atcaagaagt
     7201 tggactccag ctttagagag gtgtgtaatg aagcaggtct aaaaggccta cacgcagagt
     7261 gtctgagggt ttgtggcaac tggctggcag agacttgcct agaaaatcct gcagtcatca
     7321 tgcagaccta tctagaaaag gcagtgaagg ttgctggcag ttatgatggc gacagccgag
     7381 agctcagaaa tggacagatg aaggccttcc tctcattagc gcggttctct gatacgcagt
     7441 accagaggat tgagaactac atgaagtcgt ccgaattcga aaacaagcaa gctctcttaa
     7501 aaagagccaa ggaagaagtg ggtcttataa gggagcataa aattcagacg aacagataca
     7561 caataaaggt tcagagagaa ctggagctag atgaatgtgc tctccgtgca ctgaaagagg
     7621 accgtaaacg cttcctgtgt aaagcagttg agaactacat cagctgctta ctaagcggag
     7681 aagaacatga tctgtgggtg ttccgactct gctccctctg gctggaaaat tctggagtct
     7741 ctgaagtcaa tggcatgatg aagagagatg gaatgaagat ttcctcctat aagtttttgc
     7801 ctctcatgta ccaattggct gctagaatgg ggaccaaaat gacaggaggc ctaggatttc
     7861 atgaagtcct caataatctc atctctagga tttcaatgga tcacccccat cacaccttgt
     7921 tcatcatcct ggccttagca aatgcaaaca aagatgagtt tttgagcaaa ccagagacag
     7981 caagaagggg cagaataacc aagaatgcac ccaaagaaag ctctcagctt gatgaggatc
     8041 gagcagaggc tgcaagcaga ataatccata caatcagaag tgcgaggcgt acaatggtga
     8101 aggacatgga ggcgctctgc gatgcctaca tcatcctggc gaacctggat gcctctcagt
     8161 ggaggaacca gagaaaaggc atcagcattc cagccaacca gccaatcact aaactgaaga
     8221 atttagaaga cgttgttgtt cccactatgg aaattaaggt tgaccccaca ggagagtatg
     8281 aaaagctggt gactataaag tcatttaaaa cagaatttcg cttagccgga ggcttaaatt
     8341 taccaaaaat aatagactgt gtgggttctg atggcaagga aaggagacag cttgtgaagg
     8401 gccgcgatga cctgaggcaa gatgctgtca tgcagcaggt tttccagatg tgcaatatgc
     8461 tactgcagag gaacaccgag actagaaaga ggaaactgac catctgcaca tacaaggtgg
     8521 ttcccctctc ccagcgaagc ggtgttcttg agtggtgcac aggaaccatc cctattggtg
     8581 aatatcttgt taacaacgaa gaaggtgctc ataaaagata caggccaaat gatctcagcg
     8641 ccaatcagtg ccaaaagaaa atgatggaag tgcagaagaa gtcttttgaa gagaagtatg
     8701 agaccttcat gactatttgc caaaactttg agccagtttt ccgttacttc tgcatggaaa
     8761 aattcttgga tccagctgtt tggtttgaga aacggttggc gtatacgcgt agtgtggcca
     8821 cgtcgtctat cgttggttac atccttggac ttggtgatag gcatgtccag aatatcctga
     8881 taaacgagca gtcagcagaa cttgtgcaca tagatttggg agtggctttt gaacagggga
     8941 agatccttcc cactccagag acagttcctt ttagactcag cagagatatc gtggacggga
     9001 tgggtatcac tggtgtggaa ggtgtcttca gaaggtgctg tgaaaaaaca atggaagtta
     9061 tgcgtagttc ccaggaagct ctgctcacca ttgtagaggt tcttttgtac gacccgctct
     9121 ttgattggac tatgaaccct ttaaaagctt tgtacttaca gcagaggcca gaagacgaga
     9181 ctgacctcca gtccaccccc agtgcagacg atcaggagtg caaacgaagt cttagtgata
     9241 ctgaccagag tttcaacaaa gtagctgagc gcgtcctgat gagattgcaa gagaagctga
     9301 aaggcgtgga ggagggcacc gtgctcagtg tgggcggaca ggtgaacctg cttatccagc
     9361 aggccatgga ccccaaaaac ctcagccgac tcttcccagg gtggaaagcg tgggtgtgac
     9421 cttcagtaga ggagttgctg gacttcagaa aggacctgcc acccaccata tttggatagg
     9481 aattactgaa gtgaacaact gcttttaaac caattgtcta cttgattgat caccacccaa
     9541 atattagtat tcattcctgc tgtcttctgt tagaggcgat ggttactcaa gatccctgtg
     9601 ctgactctta gatcatgctt gtgttaccac agtggtcacc cacacgcaca ccgaactgca
     9661 aacagtggga gtggcagagt gagcttaact ttggtgtact ttaagacaag atcgtaacaa
     9721 tcttagttaa agcatgtttt ccagacagtg tgtgtg
//
LOCUS       NM_001436477            1674 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436477 XM_063265204
VERSION     NM_001436477.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265204.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11603.1,
                                           SRR26643298.45831.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  99544152-99544332   c
            182-228             JAXUCZ010000008.1  99539758-99539804   c
            229-296             JAXUCZ010000008.1  99536696-99536763   c
            297-377             JAXUCZ010000008.1  99530685-99530765   c
            378-403             JAXUCZ010000008.1  99528916-99528941   c
            404-492             JAXUCZ010000008.1  99528426-99528514   c
            493-594             JAXUCZ010000008.1  99527621-99527722   c
            595-683             JAXUCZ010000008.1  99526363-99526451   c
            684-856             JAXUCZ010000008.1  99525667-99525839   c
            857-941             JAXUCZ010000008.1  99524785-99524869   c
            942-1674            JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1674
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..181
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Morf4l1"
                     /note="upstream in-frame stop codon"
     CDS             142..1026
                     /gene="Morf4l1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 2"
                     /protein_id="NP_001423406.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKKEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQ
                     PPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKN
                     VDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILA
                     DHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATL
                     FSASDYEVAPPEYHRKAV"
     misc_feature    184..>294
                     /gene="Morf4l1"
                     /note="CHROMO (CHRromatin Organization Modifier) domains
                     and chromo shadow domains; Region: CD_CSD; cl28914"
                     /db_xref="CDD:475127"
     misc_feature    184..>294
                     /gene="Morf4l1"
                     /note="CHROMO (CHRromatin Organization Modifier) domains
                     and chromo shadow domains; Region: CD_CSD; cl28914"
                     /db_xref="CDD:475127"
     misc_feature    463..990
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    463..990
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     exon            182..228
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..296
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..377
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..403
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..492
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..594
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..683
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..856
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..941
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1674
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggcgct ggcaaatcgc gcccaggatg tagagctggc tgttcccgac ggcgcgtctg
       61 acgctaaatt gggtggggta gagagtaggg ggcggtagtc gggggtggtg ggagaaggag
      121 gaggcggcga atcacttata aatggcgccc aagcaggacc cgaagcctaa attccaggag
      181 ggcgagcgag tgctgtgctt tcatgggcct cttctttatg aagcaaagtg tgtaaaggtt
      241 gccataaagg acaaacaagt gaagtatttt atccattaca gtggctggaa taaaaaggaa
      301 caatatgcag agggcaagat gagaggggct gctccaggga agaagacatc cggtctgcaa
      361 cagaaaaatg ttgaagtgaa aacaaaaaag aacaaacaga aaacacctgg aaatggagat
      421 ggtggcagta ccagtgagac ccctcagcct cctaggaaga agcgagcccg ggtagatcca
      481 accgttgaaa atgaagaaac attcatgaac agagttgaag ttaaagtgaa gattcctgag
      541 gagctgaaac catggcttgt agatgactgg gacttgatca ccagacaaaa gcagcttttt
      601 tatcttcctg ccaagaagaa tgtggattcc attttggagg attatgcaaa ctataagaag
      661 tctcgaggaa atacagataa taaggagtat gctgttaatg aggttgtggc agggataaag
      721 gagtacttca atgtaatgtt gggcactcag ctactctaca aatttgagag accacagtat
      781 gctgaaattc tggccgatca cccggatgca cccatgtccc aggtgtatgg agcgccacac
      841 ttactgagat tgtttgtgcg aattggagcg atgttggcct atacacctct agatgagaaa
      901 agccttgctt tattactgaa ctatctacat gatttcctca agtacctggc aaagaattct
      961 gcaactctgt tcagtgccag tgattatgaa gtggctcctc ctgagtacca tcggaaagcc
     1021 gtgtgaggag tgtgctctct cactcgtgct tggatctctg taaacagttt ggttcttagt
     1081 ccttctcttg tacaaatgat gtactttgaa gaccgttagt gtataacaga gttgatgttt
     1141 gtttcctgtt tgattttaaa cagagaaaat aaaaggagtt aactgctcct tttttctttc
     1201 tttttttcat ttcaaagttt ctaccagtgt atcagtgatg gacaacggag agacatgctg
     1261 tagagtgttt gcctagttga caaagctgct tttgaatgct ggtggttctg ttcctttgac
     1321 actacgcact tttataatat gtgttaatgc tctatgacaa aatgctctga ctcctagtgc
     1381 caaaggttcc cttcagtgtg tataactgaa cactcatcca tctgtgctct tttttttttt
     1441 aaatggtgct taaagagccc atcctttgca agtcatccat gttgttcctt aggcatttta
     1501 tctttgctca attgttaaag aatggtggct tgttttcatg gtttttgtat ttgtgtctaa
     1561 tgcacgtttt aacatgatag acgcaatgca tcgtgtagct acagttttat ggaaaagtca
     1621 atcttgtagg agttgttttt cagatcttca ataaattttt tctttaaatt tcaa
//
LOCUS       NM_001436515            6387 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 38
            (Zbtb38), transcript variant 2, mRNA.
ACCESSION   NM_001436515 XM_063265584
VERSION     NM_001436515.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6387)
  AUTHORS   Miotto,B., Chibi,M., Xie,P., Koundrioukoff,S., Moolman-Smook,H.,
            Pugh,D., Debatisse,M., He,F., Zhang,L. and Defossez,P.A.
  TITLE     The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common
            fragile site stability
  JOURNAL   Cell Rep 7 (2), 575-587 (2014)
   PUBMED   24726359
REFERENCE   2  (bases 1 to 6387)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   3  (bases 1 to 6387)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 6387)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
REFERENCE   5  (bases 1 to 6387)
  AUTHORS   Kiefer,H., Chatail-Hermitte,F., Ravassard,P., Bayard,E., Brunet,I.
            and Mallet,J.
  TITLE     ZENON, a novel POZ Kruppel-like DNA binding protein associated with
            differentiation and/or survival of late postmitotic neurons
  JOURNAL   Mol Cell Biol 25 (5), 1713-1729 (2005)
   PUBMED   15713629
  REMARK    GeneRIF: ZENON is involved in the maintenance of panneuronal
            features and/or in the survival of mature neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265584.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2113359.1,
                                           SRR26643285.32338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000008.1  106196421-106196614 c
            195-6387            JAXUCZ010000008.1  106161802-106167994 c
FEATURES             Location/Qualifiers
     source          1..6387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..6387
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
     exon            1..194
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="upstream in-frame stop codon"
     exon            195..6387
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..3806
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zenon; zinc finger protein expressed in neurons;
                     zinc finger transcription factor Kaiso"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001423444.1"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQE
                     TVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTN
                     GPRITNAFSIIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTL
                     AEHSYAVSSITEAYRSQPLREHDSSSSSGKTGKENGEALTTKAKPCRKPKTQTQDSDS
                     TTENMPLPLVTCPEVNQERSPQPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAA
                     EVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQIC
                     MRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRIGELSSAGSALSDADHMV
                     KFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIW
                     HTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYR
                     LLPMRCKRAPYKSYRNSSYESAQGNRQRNESPPDTFVIPNLPSSEMPTLNFQDGRNSL
                     TSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQALKTDLVDSAEVSISSIGNSVSTTL
                     QAEPVCVSSGEHSASVISYSGSVPSVIVHSSQFSSVIKHSNAIACLANSNHQSPSQPV
                     ASPSLIKDSKPEADKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLGGSSGKTT
                     NVVEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGR
                     KPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNY
                     KPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELDRCAEVKL
                     PPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHLTLKPYICELCAKQFQSSS
                     TLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETL
                     KIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKICKTAAA
                     LRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDSEDSDQKDDIKKPLLKMSFE"
     misc_feature    237..578
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    237..578
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    582..584
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3; propagated from
                     UniProtKB/Swiss-Prot (Q5EXX3.1); phosphorylation site"
     misc_feature    882..1196
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1089..1760
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Interaction with CBFA2T3.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3"
     misc_feature    1116..1397
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1116..1397
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1221..1283
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1221..1283
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1221..1223,1230..1232,1269..1271,1281..1283)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1221..1223,1230..1232,1269..1271,1281..1283)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1308..1367
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1308..1367
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1575..1637
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1575..1637
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1575..1577,1584..1586,1623..1625,1635..1637)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1575..1577,1584..1586,1623..1625,1635..1637)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1590..1592,1596..1598,1602..1604,1608..1613,
                     1620..1625,1632..1634,1674..1676,1680..1682,1692..1697,
                     1704..1709,1716..1718,1758..1760,1764..1766,1770..1772,
                     1776..1781,1788..1793)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1590..1592,1596..1598,1602..1604,1608..1613,
                     1620..1625,1632..1634,1674..1676,1680..1682,1692..1697,
                     1704..1709,1716..1718,1758..1760,1764..1766,1770..1772,
                     1776..1781,1788..1793)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1659..1721
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1659..1721
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1743..1799
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1743..1799
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1935..2126
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2385..2522
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2763..2840
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2877..2936
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3249..3311
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3249..3311
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3249..3251,3258..3260,3297..3299,3309..3311)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3249..3251,3258..3260,3297..3299,3309..3311)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3264..3266,3270..3272,3276..3278,3282..3287,
                     3294..3299,3306..3308,3348..3350,3354..3356,3366..3371,
                     3378..3383,3390..3392,3432..3434,3438..3440,3444..3446,
                     3450..3455,3462..3467,3474..3476)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3264..3266,3270..3272,3276..3278,3282..3287,
                     3294..3299,3306..3308,3348..3350,3354..3356,3366..3371,
                     3378..3383,3390..3392,3432..3434,3438..3440,3444..3446,
                     3450..3455,3462..3467,3474..3476)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3288..3359
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3288..3359
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3327..3395
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3327..3395
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3333..3395
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3333..3395
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3417..3479
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3417..3479
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3456..>3512
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3456..>3512
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3501..3563
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3501..3563
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3594..3656
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3594..3656
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3708..3803
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 acaaacccga gctgcttcct gaccctaccg gatcgcgttg agattctagt gcgacaccaa
       61 gcccctggaa ttgaaccgga cgttcaaagg cagggccctg cccccagggg ttgcagcctc
      121 ggcctccagc tcctactgca gcggtctgtc tgttgggaca attcaacagt cagcctttag
      181 acacttcttt gcagatgaca gtcatgtccc tctccaggga cctcaaggac gactttcaca
      241 gtgacacggt gctctccatc ctaaatgagc agcgcattcg gggcatctta tgtgatgtca
      301 ccatcattgt ggaggacacc aagtttaaag cccacagcaa tgtcctggcc gcctcaagcc
      361 tttatttcaa aaacatcttt tggagccata cgatctgtat ttccagtcat gtcctagagc
      421 tggatgatct gaaagccgaa gtgtttacag agattcttaa ttacatctac agctccaccg
      481 tggtggtcag gagacaggaa accgtcactg accttgcagc tgcagggaaa aggctgggaa
      541 tatcattctt agaggacctt agtgaccgca acttctcaaa ttccccaggt ccttacgtag
      601 tttgcatcac tgaaaagggc gtggttaaag aagaaaaaaa tgaaaaaagg cacgaagagc
      661 cagctgtcac taatgggccc aggatcacaa acgcattttc catcattgag acggaaaata
      721 gcaatagcat gttttctccc ctggacttga gggcaagctt caaaaaagtg tcagatgcca
      781 tgagaaccac tagcctttgc caggagagag ccagtgtctg ccccgaggca gagcctgtcc
      841 gcacgcttgc cgaacactca tatgccgttt cttccatcac tgaggcctac aggagtcagc
      901 ctctgaggga acatgacagc agcagttcat ctggtaaaac gggaaaagaa aatggcgaag
      961 ctctcaccac aaaagcaaag ccatgccgaa agccaaagac ccaaacccag gattctgact
     1021 caaccacaga gaacatgcca ctccctctag taacctgccc agaggtgaat caagaaagaa
     1081 gcccacagcc agctccaatt ctgtcacact cagaacctcc cagcagtgaa ggagatgtcc
     1141 attttcccag agaagatgaa aaccagccct ctgagactcc tggtccccca gcagcagagg
     1201 tcccgcccct cgtttataat tgtagctgct gctccaaatc cttcgacagc agcacactgc
     1261 tcggggccca catgcagctg cacaagccga cgcaggaccc ctttgtgtgc aagtactgca
     1321 acaagcagtt caccaccctc aacaggctgg accggcacga gcagatctgc atgaggtcga
     1381 gccacatgcc catgccagga ggaaaccaac ccttcttaga aaactacccc accattggac
     1441 aagatggagg ttcattcaca agcccagatt cattggtgcc agaaagtagg attggtgaac
     1501 tatccagcgc tgggagtgcc ttgtcagacg cggaccacat ggtgaaattt gtgaatgggc
     1561 agatgcttta cagctgcgtt gtgtgcaaac gtagctatgt gactttgtcc agcctccgga
     1621 ggcacgcaaa tgtccactcg tggagaagaa cgtacccttg tcattactgc aacaaggtct
     1681 tcgcactggc tgagtacagg acacgacatg agatctggca cactggagag aggcggtacc
     1741 agtgcatttt ctgtcttgaa acgtttatga cctactacat actgaaaaac catcagaagt
     1801 cttttcatgc catagatcac agactctcca tcagtaaaaa aacagcaaat ggaggcttga
     1861 agcccaccgt ctacccatac aaactttaca ggctcttgcc tatgagatgc aagcgggcac
     1921 cttataagag ctaccggaat tcttcctatg aaagtgctca aggaaaccgt caaaggaatg
     1981 aatccccacc tgacaccttc gtcattccga atctgccaag ctctgaaatg cccacactga
     2041 acttccaaga tggcagaaac tcgttgacca gcagccctgc catcccagtg gaaacacctt
     2101 catggcaggg tacacccact tctgccaaag taaaaaatgc agaaggcctc aaatggagga
     2161 agcaggcact gaaaaccgat ctcgtcgatt cggctgaggt gtcgatttct tccattggaa
     2221 actctgtcag caccaccctg caggcagagc ccgtgtgtgt ttcgagtggg gagcactcgg
     2281 cctccgtgat cagctacagc ggctcggtgc cctctgtcat tgtgcacagc agccagttct
     2341 cgtcggtgat caagcacagc aatgccattg cctgcctggc caacagcaac caccagtccc
     2401 cttcacagcc tgtggcgagt ccgtccctga tcaaggatag caagcctgag gcagataaag
     2461 ccagtaaact cgcaagcaga cccaaaaact ctaaggagaa aaagaaaacc gttccatgta
     2521 acaggggaga aataacagag gaggcaaaat atgttgctga tctcggagga tcttcgggca
     2581 aaaccacaaa tgtcgtcgaa gaaaccagta agattgaaac ttatatagca aaacccgctc
     2641 tgcccggcac ctccacaaat agcaatgttg cacccctttg ccaaataaca gtgaaaattg
     2701 ggaacgaagc catcgtgaaa aggcatatcc ttgggtctaa gctgttttac aaaagaggga
     2761 gaaaacccaa gtatcaaatg caggaagaga cattgcctcg ggagagtgac cccgaaaccc
     2821 gtggagacag ccctcttggg ctctgccaag ctgactgtgt ggagatgagt gaagcatttg
     2881 atgaagtgag tgaccaggac tccaccgata agccgtggcg cccatactac aactacaagc
     2941 ccaagaagaa atccaaacag ttaagaaaaa taaggaaagt caagtggagg aaggaacgag
     3001 ggagcagaag ccccgtgggt cggcgcaggt atccagctga gctggatcgc gcagagatgg
     3061 gtcggcgcag gtacccagct gaactagatc gctgcgcaga ggtgaaattg cccccagata
     3121 aggcctctga agaagaggag aataaagaga tgcccaagct gcagtgcgag ctctgtgacg
     3181 gtgacaaagc agcaggggcg ggagccgaag gcaagcccca ccagcatctc actctgaagc
     3241 cttacatctg cgagctctgt gcgaagcagt tccagagctc ctccacgctc aagatgcaca
     3301 tgagatgcca cactggcgag aagccctacc agtgcaagac ctgtgggcgg cgcttctcag
     3361 tgcagggcaa cctacagaag cacgagcgca ttcacctggg cgtgaaggag ttcatctgtc
     3421 agtattgtaa caaggctttc acgctgaacg agacactcaa gatccacgaa agaatccaca
     3481 caggggagaa gcgttaccac tgtcagttct gctttcaggg tttcttatat ctctccacaa
     3541 aaaggaacca cgagcggagg catgtccggg agcatgacgg gaaaggcttt gcttgcttcc
     3601 agtgccccaa aatatgcaaa acagctgctg ccctcagaat gcaccaaaag aagcacttat
     3661 tcaagacctt gactaagcaa gaggaaacag atgacctttg ccacgaaaac tccgatctct
     3721 tggagagtca accttgcact gattcggaag acagcgacca aaaggatgac ataaaaaaac
     3781 ctttgctgaa aatgtccttt gagtgacaac agttagaaag gtcttcaaaa ttgtttgtga
     3841 ttttttttat ttttagtttt ttaagttttt ttaagcttag ttttgttcac ataatattct
     3901 caaaggatgg ggggttgtta attttccttt gtgtaaactc cccccaaaaa ggatcctaac
     3961 aactattttg ggttttatca ttcactctac acagaatgca taaaaacaaa ctagctgaat
     4021 cctctaacga ccgagtattt tgtgaaggct aatgaagttc tgagctgtgg gattttgaac
     4081 agtggaaaga gcagctggat tttagcctaa tttaagcctt tctctcgcgc actaatgagg
     4141 tctgctgaac tgttgttagt cactggagag agtaagggtc aggatcgtgc agatggcatc
     4201 tttgagacat gctaaacgag ctatgacagt atttattgcc attgagtttc tgcactatta
     4261 atctttggta aactgatggg tatttacaaa atatctaaca atataactga acatatgtaa
     4321 tgggtaacct aaagtaggac attctcatat cacctagaga cacttttctg cagcataaac
     4381 cttgtaaagt acgtatatga atcactataa cgtttagctg tctgtctgtc cctagtagag
     4441 aaccacaaga gcaatagacc tcagataaca cggactgctg tagaaatcag tagaacattt
     4501 ggaatctggc tgacgagcat gtgtgtgctt ctcgatggag tgctgtgctg ttctcctgaa
     4561 gtatggctga gctgttagtt gaactggtcc actcaagtca cacagaacat aggtcatgcc
     4621 ttatctatga gaaaaccttc ctagacttac ctgagattac ctatgccaca cagtcctctg
     4681 cagtggcctc acctcagaat gaagaatgat cacattcttc agaactctgc agtcttccag
     4741 tcatcccaag gccatggatg ttggggggct atcccaccca acttctgtgg tcaaataatc
     4801 ctggtccctc ccattccact gaagcagcag ctggaggctg agggagagac acacctctgt
     4861 ggtaatcaat ctcagtccct tggaaaggcc gaaagcctga ttcctcaggt ttacatctcc
     4921 ttggagctaa tgcagcacac aggtacatag tagtgaaaag ggccacagac tccttacccc
     4981 cactgataac atgaggacag ggggacctga tgcctccaac agcagcattg tttttgaggg
     5041 atggggagat agaatgtgga atgacagtgt tctgcccctt acaaacatga ctcgaaacac
     5101 ccacaaagcc agatgcccct ccttcgtgtt cgcagacatt agctctctgt taaagcccca
     5161 cttttacttc taaatccttc taaatattga ctcagactgt caacattgcc ctcaaaagtc
     5221 tccttgccct acaggtattt tttcatggga actagggtcc tggaaagctg gaactcaaaa
     5281 gattcttact gttaacactg gcagaatagg agggagggag aacacagcct acccttccag
     5341 caccagaatg ggcaaaactc agaacaggtt aagtagtcgt tcccgctcgt tggattgagt
     5401 aggtggaaag ccaaggctgg aaggttatca gaggactctg gtttctccca cccagtgttg
     5461 tgttgcctcc acgaagaagg cttagcatgg tttggggtag gcaacattta aacacccaga
     5521 aaaaaggaca tgattcaagg tgacctttat actgtagcac tttgctgtta cccccaatat
     5581 gtatctgcat ttgtcatttg ttcatctccc tttacctaca tacagtatta tatagaggac
     5641 atggggaaac gcaagcaatt gaactttgtt ttgtccattg tatatatgtg cacccacacc
     5701 atttgagttt tattgaagta gtcacaaagg gcttatgaaa atcacttttg aattaataac
     5761 cagatgacaa gcaatcctgt gatccactaa tatgttttat ctcagttatg attataaaac
     5821 aattatggat ttaagttgtt ttgatttaac tacaaataaa gttatatgta ttgatgtctc
     5881 ccatcaatat gtggatattt tttaagtgga cttgtatgct gataattcta gaccaaagta
     5941 aatatggcag aatatttata catacaaata attttgcaaa tattttctat aattgtatta
     6001 ttcatttaaa atgttgatag cttgtgttag tttcagggag ggggtgtata ttttgataaa
     6061 atacttgact ttgtaattct gtatattcta tacaatttat agcagagcca ttttaagaca
     6121 actggttaca tttttttgtt gattgtgtaa atgttatgag tggtgtttaa gtatgcatca
     6181 agtacataat gaccaagtag aattaaagtg taaacagtga acatactgta tgctgtaaag
     6241 atatattgta acttgctgtt tttagcatct gtattttggt taggaaatat gattaaatgc
     6301 agatgttaag ggttggaaag gtctaatttt atttttagaa ataatgaata taaatttgtt
     6361 ttgcttgatt aaaatagctc attccta
//
LOCUS       NM_001436497            5437 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 7, mRNA.
ACCESSION   NM_001436497 XM_063265387
VERSION     NM_001436497.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5437)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5437)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5437)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265387.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.44544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000008.1  38090295-38090648
            355-527             JAXUCZ010000008.1  38092744-38092916
            528-729             JAXUCZ010000008.1  38095209-38095410
            730-857             JAXUCZ010000008.1  38098165-38098292
            858-1032            JAXUCZ010000008.1  38099310-38099484
            1033-1134           JAXUCZ010000008.1  38100022-38100123
            1135-1208           JAXUCZ010000008.1  38100738-38100811
            1209-1293           JAXUCZ010000008.1  38101595-38101679
            1294-1474           JAXUCZ010000008.1  38102404-38102584
            1475-1583           JAXUCZ010000008.1  38103121-38103229
            1584-1710           JAXUCZ010000008.1  38103788-38103914
            1711-1776           JAXUCZ010000008.1  38104177-38104242
            1777-1856           JAXUCZ010000008.1  38105285-38105364
            1857-1903           JAXUCZ010000008.1  38105453-38105499
            1904-1964           JAXUCZ010000008.1  38106233-38106293
            1965-2139           JAXUCZ010000008.1  38106533-38106707
            2140-2246           JAXUCZ010000008.1  38108447-38108553
            2247-2370           JAXUCZ010000008.1  38110471-38110594
            2371-2450           JAXUCZ010000008.1  38111060-38111139
            2451-2665           JAXUCZ010000008.1  38111280-38111494
            2666-2936           JAXUCZ010000008.1  38111574-38111844
            2937-3149           JAXUCZ010000008.1  38112380-38112592
            3150-3917           JAXUCZ010000008.1  38114925-38115692
            3918-4024           JAXUCZ010000008.1  38118990-38119096
            4025-4160           JAXUCZ010000008.1  38119994-38120129
            4161-5437           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5437
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..354
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            355..527
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             393..4286
                     /gene="Nfrkb"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 3"
                     /protein_id="NP_001423426.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSW
                     LPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKHHEKRKHQPDHPD
                     LLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKLIKSEAEDLA
                     EPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQ
                     ASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVE
                     FKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDAMTPVPRVRTDY
                     VVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREH
                     SLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVS
                     GALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKP
                     PSKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPALPTPISPPPVSA
                     VSRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQTTARVVSHSSSA
                     GLPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKVVPQAVVATVPV
                     KGQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSASTTAVIQNVTGQ
                     NIIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITP
                     DMMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVP
                     SSAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVASSEAKPAATIRI
                     VQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINATVSKTVAVASGA
                     TSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMKGKSVVTAPII
                     KGNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTV
                     PASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1566..1826
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1566..1826
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2439..3053
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2439..3053
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3336..>3956
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <3336..>3956
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            528..729
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            730..857
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1032
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1134
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1208
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1293
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1474
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1583
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1710
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1776
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1856
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1903
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1964
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2139
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2246
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2370
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2450
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2665
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2936
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3149
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3917
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4024
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4160
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..5437
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggtgggg ctggagacgt ggggctacgg ccggagagcc ttgctcgcag cttgctcggg
       61 agggtctgga gggtgggcta gccccaggtg cagagaagag gccttcctgg tctagcgagg
      121 aagtcccgga caccccaaca cttagaaatc tgcagcttcc ggggtttcag ctcgctggta
      181 gcgccggtgt tttcgtattt tgagagagta agtggcaaga cagaggttgt cactagatat
      241 taacgtttag cttaaccaac cgtcggcact ggaagaagct tctgagcgag ttgtgtacat
      301 tatgcacctg tcagatgagg taactgactt tgcacgctgc ctatgccacg tacgggtgta
      361 tttttaggta gtgtacctgt ggagaagaaa caatggattc cttggatcac atgctgacag
      421 atcccctaga acttggtcct tgtggagatg gtcacagtac agggatcatg gaggactgcc
      481 ttctgggtgg aaccagggtt agtctgcctg aagacctgct ggaggatcct gaaatattct
      541 ttgacgtcgt cagcctctcc acatggcagg aagtactaag tgactctcag cgtgaacatc
      601 tccagcagtt tctgccgcag tttcctacag acactgtaga gcagcagaat gagctcatcc
      661 ttgccctatt cagtggggag aacttccgct tcggaaaccc tctgcacatc gcccagaagc
      721 tcttccgaga tggacacttt aaccctgagg tggtcaagta tcggcagctc tgcttcaagt
      781 cacagtacaa gcggtacctc agctcccaac agcagtattt ccaccggctg ctgagacaga
      841 ttcttgcttc cagaagtgat ctcctggaga tggctcgcac gagcggcccg gctcttccct
      901 ttcgacacaa gcaccattca ccatcccgaa gcccggagga gcgggagtgg cggacccagc
      961 agcgttacct gaaagtcttg agggaagtga aggaggagtg tggcgacact gccctgtcgt
     1021 ctgatgagga ggatctcagc tcatggcttc caagctctcc agcacgctct cctagtcctg
     1081 cggtgcccct gagggtggtg cccacgcttt ccaccacgga tatgaaaact gcagataaaa
     1141 tagaactggg ggacagtgac ctgaagttaa tgttaaagaa acaccatgag aagcggaaac
     1201 atcaaccaga tcacccagac cttttgacag gggatctgac tctcagcgac atcatgactc
     1261 gagtaaatgc cggcaggaag ggctctctag cagccttgta tgatttggct gttcttaaaa
     1321 aaaaggtgaa ggaaaaggag gagaagaaaa agaagaaaat aaagttgatt aaatcggagg
     1381 cagaggatct ggctgagccc ctaagcaata ctgaaggggt cccaacgctc tcccaggccc
     1441 cctctcccct ggcaatatcg tctatcaagg aagaacccct ggaagacatc aagccttgtc
     1501 ttggaatcaa tgaaatatct tccagttttt tctctcttct gttagagatc ttgctgctgg
     1561 agagtcaggc tagccttcct atgctggagg accgggtttt ggattggcag tcttctccag
     1621 ccagctccct caacagctgg ttctctgctg cccccaactg ggctgagttg gtgttgcctg
     1681 ctctgcagta tcttgctgga gaaagccgag cagttccttc cagtttttct ccatttgttg
     1741 aattcaaaga gaaaacccag cagtggaaat tgcttggtca atctcaagat aatgaaaagg
     1801 aattagccgc tctcttccac ttgtggctag aaaccaaaga ccaggctttc tgtaagcagg
     1861 aaaatgaaga cagctcagat gccatgacac ctgtgcctcg agtaagaact gactatgtgg
     1921 ttcggcctag cacaggagag gagaaacggg tttttcaaga gcaggagcgt tacaggtata
     1981 gccaacccca taaggcattc acctttcgca tgcatggctt tgagtctgtg gtggggccag
     2041 tgaagggcgt gtttgacaag gagacctccc tcaacaaggc tcgtgagcac tcactgctgc
     2101 gctctgaccg gcctgcctat gtcaccattc tgtctcttgt tcgggatgct gcggctcggc
     2161 tgcctaatgg agaaggcact cgggcagaga tctgtgagct gctcaaggac tctcagtttc
     2221 ttgctcctga tgtcaccagc actcaggtga acacggtagt gagtggcgca ctggatcgat
     2281 tgcattatga gaaggaccct tgtgtgaaat acgacattgg tcggaagctg tggatctacc
     2341 tgcatcgtga ccggagtgag gaagagtttg aacggatcca tcaagctcaa gcagcagcag
     2401 ctaaagccag aaaagctctt cagcaaaaac ccaaaccgcc atccaaggtg aagtccagta
     2461 ataaggaggg ctccgtgaag ggccttagtg gtccttctga gcccagccag atgagcctca
     2521 gtgactccag catgccacct accccagtta cgcctgtaac ccccaccacg ccagcattgc
     2581 ctacccctat ctctcctcca cctgtgtcag cggtgagcag aagtggctct accactgtct
     2641 ctgagccagc caagtctagt tcaggtgttc ttctggtgtc ctcaccaaca atgccacagc
     2701 taggaacgat gctttcccct gcttccatcc agactccgcc cagttctcag accactgctc
     2761 gggttgtcag ccattccagc tcagcaggac tgccccaggt tcgggtagta gcccagccca
     2821 gccttcctgc tgtttcccag cagtcagtag ggccagcaca gccactaccc cagatgccag
     2881 caggaccaca gatccgtgtg ccagtcaccg ctacccaaac caaagtagta ccccaggcag
     2941 ttgtggctac agttccagtc aaggggcaga ctacagcggc ctctgtgcaa cggcctggac
     3001 ctgcacagac aggacttaca gtgacgagtc ttcctgctgc agttagcccc gggagcaaga
     3061 cagccatgag ttctcctggg agctctgctc caagtgcctc cacaaccgcc gtcattcaga
     3121 atgtcacagg acagaacatc atcaagcagg tgtcaatcac tggacagctt ggtgtgaagc
     3181 cccagacagg caacagcatt ccactcacag ccacaaactt ccgtatccag ggtaaagatg
     3241 tactgcgcct gccgccttct tccatcacca cagatgccaa gggccagacg gttctgagaa
     3301 tcactccaga catgatggcc acactggcca agtctcaggt caccacagtc aagttgactc
     3361 aggacctctt tggggcaggt agcggcactg caggcaaagg catctctgct accttgcatg
     3421 tgacttccaa ccctgtccat gcggctgaca gccctgccaa ggccccttca gccagtgttc
     3481 cttcatcagc tccagcgggc actaccgtgg tcaaagtaac tcctgatctc aagccaacag
     3541 aaacctccag ttcagctttt cgcttgatgc cagctcttgg cgtgagtgtg gcagatcaga
     3601 aggggaagaa cacagtggcc tcttcagaag caaaacctgc tgccacaatc cgcattgtgc
     3661 aggggctggg agtgatgcct cctaaagcag gccagaccat tactgttgca gcacatgcaa
     3721 agcaaggagc ctctgttgct ggtgggtctg gaactgtcca ttcttcaact gtgtccttac
     3781 ccagtatcaa tgccactgtg tctaagactg tggctgtggc ttctggagca acaagcaccc
     3841 ccatcagcat cgggactgga gcccccaccg tgcgacaggt tcctgttaac actacagttg
     3901 tgtccacatc ccagtctggg aagctgccta ccaggatcac agttcctctc tctgtgatta
     3961 gccagccaat gaagggcaag agcgtggtca cagcccccat catcaaaggc aaccttggag
     4021 ccaatctcag tgggctgggt cgcaacatca tcctcacaac catgccagcg ggtgctaagc
     4081 tcattgctgg caataagcca gtgagtttcc tcaccgccca gcagttgcag cagcttcagc
     4141 agcaaggtca ggctacacag gtacgcatcc agactgtgcc agcatcccat ctgcaacagg
     4201 gcacagcttc cggctcctcc aaagccgtgt ccactgttgt tgtgaccaca gctccatctc
     4261 ctaaacaagc acctgagcag cagtgactga gaagaaaggc ggcttcttta agagaccagg
     4321 cctggtttat ctcggctgac agaaagggag cagggaggct gcaccattct tctgagctgt
     4381 cctgcttgag gcagggtggt ggagagtgat ggcaactgtg gcctagattg tgctgccaca
     4441 ctccagagtg aagccctttt tagggttcca gggatgatct gttatcctgg actaccagga
     4501 agagggaagg aacatcagag tctggggagg tcacagtcac acaagccggg gttacctcct
     4561 gaatgttggg ttcccaggga gcaggcctgc cagttggtga gtggaccggc agggaataag
     4621 cctcattctg tgtgaggatt ttacttttta gtttctgatc ttctccgtga cttgttgaga
     4681 tgtgagtttt gtgtccagag aatttttgtg taacttattt ttttaaagaa cctactctac
     4741 gtcttttatc aaatagaaac ctgggcttca gtgcccctaa actgatcact taccccttca
     4801 accagaatga gagcatagca agactcttaa tagtttggcg gcttacttga taatggagag
     4861 gttatatagt aagaaaatgt aggccttgag ttagcatgga ccccctcaag tgggactagt
     4921 tcaatgccgt gtactaaata tgggcatctg aatctcggtt gtccctatgt cttctcttgt
     4981 gggcattgtc cttgacaagc ctgttcatgg aagttcagag cttttggaca ggagtagggg
     5041 aagatgaggt gctgctctca ccgtgcactt gcttacagcc cagacattgc acattctcct
     5101 tgctgtagaa cagccattgc taaccagacc cttggagctg gccacttgac tgggacagag
     5161 aagaaatggg gaggtggggg caggggtagg cactgcctgg cagtgccatc ttgaggggaa
     5221 aggatgtttt tattctggcc atttcatatt tctcagccac caccagccac agacagggct
     5281 cagaagggta ctttacaaag tccaagtact taatgtacta ggtgtatctt aacgtgtctt
     5341 gctgtggtgc aggggtgggt aggaaaacct ttctgcaggg atagtgcttc cctgtctctt
     5401 tgtgaaaata tccaaattat taaaaacata tctttaa
//
LOCUS       NM_001436483            3333 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 2,
            mRNA.
ACCESSION   NM_001436483 XM_006243745
VERSION     NM_001436483.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3333)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243745.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.598576.1,
                                           SRR26360190.1731741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000008.1  118095438-118095575
            139-198             JAXUCZ010000008.1  118097040-118097099
            199-528             JAXUCZ010000008.1  118106884-118107213
            529-1560            JAXUCZ010000008.1  118112261-118113292
            1561-1738           JAXUCZ010000008.1  118120474-118120651
            1739-1893           JAXUCZ010000008.1  118121209-118121363
            1894-2008           JAXUCZ010000008.1  118122735-118122849
            2009-2117           JAXUCZ010000008.1  118131517-118131625
            2118-2269           JAXUCZ010000008.1  118131953-118132104
            2270-2360           JAXUCZ010000008.1  118132470-118132560
            2361-3333           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3333
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3333
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..138
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            139..198
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            199..528
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             220..2553
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423412.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <235..363
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <235..363
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    2017..2499
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    2017..2499
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            529..1560
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1738
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1893
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2008
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2117
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2269
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2360
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..3333
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatgtaaga tggcgcccag ggagctgtga ggagaaaatc ctgtcggtct tggagcagcg
       61 gtggcagaac cgaggcccca ggcggtgaag cggggccgga gggtagagtg gaggcagcgg
      121 cggcggtgac gtcgccggaa tgttagaagt cttaagaact caggacaagc agcagacata
      181 catgcaacat ggtgactgga accctaagga ctctgcaata tgaataattc tctagagaac
      241 accatctcat ttgaagagta catccgagta aaggcgaggt ctgtcccgca acacaggatg
      301 aaggaatttc tggactcgct ggcttctaag ggaccagaag ctcttcagga gttccagcag
      361 tctgccacca ccaccatggt gtaccagcag ggtgggaact gcatttatac agacagcact
      421 gaagtggctg ggtctttgct tgaacttgct tgtccagtca caaccagtgt tcaaccacaa
      481 actcagcaag agcagcagat ccaggttcag cagccacagc aggttcaggt acaggtgcag
      541 gtacagcagt ctccacagca ggtctcagct cagcagcttt ccccgcagtt caccgttcac
      601 cagcctgctg agcaacccat ccaggtccag gtgcagatcc agggccaagc accacagtcc
      661 gcagccccct ccatccagac tccatcactg cagagcccca gcccctcgca gctgcaagca
      721 gcccagatcc aggtgcagca cgtgcaggca gcgcagcaga tccaggctgc agaaatccca
      781 gaggagcata tcccacatca acagatccaa gctcagttgg tggcaggcca atctcttgct
      841 gggggccagc agattcaaat tcagaccgtg ggcgctcttt ccccaccacc ctcccagcag
      901 ggctcaccca gggaagggga gcggagggtt ggcacagcca gtgtccttca accagtgaag
      961 aaacgcaaag tggacatgcc catcaccgtg tcctatgcca tctcagggca gccagtggcc
     1021 accgtgctgg ccattccaca aggccagcaa cagagttacg tgtctttgag gccagactta
     1081 ctgacagtag acagtgccca cctgtacagc gccactggga ccataactag ccctacagga
     1141 gaaacttgga ccatccctgt ttattccgcc cagccccggg gggaccctca gcagcagagc
     1201 attacccaca ttgccattcc ccaggaagcc tacaatgcag ttcacgtcag tggctcaccc
     1261 acggctctgg cagctgtaaa gctggaggat gacaaggaga agatggtggg caccacatcc
     1321 gtagtgaaga actcccatga agaggtagtg cagacccttg caaactctct ctttccagca
     1381 cagttcatga atggcaacat ccacattcca gtggctgtgc aggctgtagc aggcacgtac
     1441 cagaatacgg ctcagactgt acatatatgg gacccacagc agcagccgca acagcaaact
     1501 gcacaagaac agacaccacc acagccacag caacagcagc agctgcaggt cacttgttca
     1561 gcacaaactg ttcaggtcgc tgaagttgag ccacagtcac aaccgcagcc ttcaccagag
     1621 cttttgcttc caaattcact gaagccagaa gaagggctag aagtatggaa aaactgggct
     1681 cagaccaaga atgctgaact agaaaaggat gctcaaaaca gattggcccc cattgggagg
     1741 cgccagttgc tacgattcca agaagatctg atctcatctg ctgtggctga attgaattat
     1801 ggcctttgtt taatgacacg agaagctcgg aatggagaag gtgaacccta tgacccagat
     1861 gtactctact acattttctt gtgtatacag aagtatcttt ttgaaaatgg aagagtagat
     1921 gacatattct ctgatcttta ctatgttcgt tttaccgaat ggctacatga agttctgaag
     1981 gacgtgcagc cccgggtcac tccacttggc tatgttctgc ccagccacgt gactgaagag
     2041 atgctgtggg aatgcaagca gcttggggca cattcccctt cgacactgct gaccaccctc
     2101 atgttcttca acaccaagta ctttctgttg aagacagtag atcagcacat gaagctggcg
     2161 ttctccaagg tcctccggca gacaaagaag agcccctcga atcctaagga taaaagcact
     2221 agtatccgct acctgaaggc cctcggaata catcagactg gccagaaagt tacagatgac
     2281 atgtatgcag aacagacaga aaatccagag aacccattaa ggtgtcccat caagctctac
     2341 gatttctacc tcttcaaatg cccccagagt gtgaaaggcc gaaatgacac cttttacctg
     2401 actcctgagc ctgttgtggc tcccaacagc ccgatctggt actcagtcca gcctatcagc
     2461 cgagagcaga tgggacagat gctgacccgg atcctggtta tacgagagat tcaagaagcc
     2521 attgccgtgg ccaacgcaac caccatgcac tgaggtgcct cagccacagg aaaaaaaaaa
     2581 atccaggaaa aaccagacag acttttacac taaaggagag gcctccattt ttttcttttt
     2641 ctttttcctt caattcgtag ttctaatgct tttcaggcga cttctgttaa aaatgtaaaa
     2701 gacaatgttg ccctctttgc atcttcataa aatgggcaga ccccctggtt catgggtata
     2761 tggttttcct agaacttgat gtcctaggaa gtggttggct tttacctttc ttttcctttt
     2821 ttttcttttg tctgggctgg agtgtggggg aagggacttg gactgtatgg agaaatatag
     2881 gcccttccct tcctcaaggc agatggagca gccgatgaat caaccctcct gcaaaccccc
     2941 acctttcact ctggaccggc aggcttaacc actcggagcc acgatttttc tttttttttt
     3001 tttttttttt ttttttaaat gctcagacat aaacttagca tcttgatgga ataaaaatga
     3061 ggggaacttc aattatgatt tttattaaag acaatttcta ttacaccctt ctttatgaca
     3121 agtgacatag atgttaaagt aaaaacttta ccatgctttt tttttttttt tttttttttt
     3181 ttggcctaac attgaggcct taaacctgag gctcctgtgc ctgatggaat tcttgtaaca
     3241 tacacttgtg tatcatataa agataccact ctttctctta tgtattctta ttctagttgt
     3301 ttattaagaa tgacaagcac gtcttttcaa caa
//
LOCUS       NM_001436487            3492 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 5,
            mRNA.
ACCESSION   NM_001436487 XM_006243750
VERSION     NM_001436487.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243750.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.485240.1,
                                           SRR26360194.42055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000008.1  118095904-118096260
            358-687             JAXUCZ010000008.1  118106884-118107213
            688-1719            JAXUCZ010000008.1  118112261-118113292
            1720-1897           JAXUCZ010000008.1  118120474-118120651
            1898-2052           JAXUCZ010000008.1  118121209-118121363
            2053-2167           JAXUCZ010000008.1  118122735-118122849
            2168-2276           JAXUCZ010000008.1  118131517-118131625
            2277-2428           JAXUCZ010000008.1  118131953-118132104
            2429-2519           JAXUCZ010000008.1  118132470-118132560
            2520-3492           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3492
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..357
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            358..687
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    364..366
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             379..2712
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423416.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <394..522
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <394..522
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    2176..2658
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    2176..2658
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            688..1719
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1897
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2052
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2167
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2276
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2428
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2519
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..3492
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctcagc tgtggcccgt gggctagaac ggcttccggg gcgcgcgctt ccccgcgacc
       61 cccagttttg tggcgcgcgc cctgctgttg gtttggttgc tcgcgctgtc cggagtacgc
      121 gcaggacgcc ccttccgaga ggagggtcgg cggcctggct gacgaccggc ttgctgagtg
      181 gggaaggttg agggttgggc ccttgccctc gtgacgtccc gggcagcggt ggcctaggtc
      241 tgcggagaaa catagcggct ttgcggtctg gcttgcggct ccgctcctcc gtgaggcgga
      301 caggattgct tgtactaacc gaagaatgct gttacttaag cgaggcccat gtactgggaa
      361 ccctaaggac tctgcaatat gaataattct ctagagaaca ccatctcatt tgaagagtac
      421 atccgagtaa aggcgaggtc tgtcccgcaa cacaggatga aggaatttct ggactcgctg
      481 gcttctaagg gaccagaagc tcttcaggag ttccagcagt ctgccaccac caccatggtg
      541 taccagcagg gtgggaactg catttataca gacagcactg aagtggctgg gtctttgctt
      601 gaacttgctt gtccagtcac aaccagtgtt caaccacaaa ctcagcaaga gcagcagatc
      661 caggttcagc agccacagca ggttcaggta caggtgcagg tacagcagtc tccacagcag
      721 gtctcagctc agcagctttc cccgcagttc accgttcacc agcctgctga gcaacccatc
      781 caggtccagg tgcagatcca gggccaagca ccacagtccg cagccccctc catccagact
      841 ccatcactgc agagccccag cccctcgcag ctgcaagcag cccagatcca ggtgcagcac
      901 gtgcaggcag cgcagcagat ccaggctgca gaaatcccag aggagcatat cccacatcaa
      961 cagatccaag ctcagttggt ggcaggccaa tctcttgctg ggggccagca gattcaaatt
     1021 cagaccgtgg gcgctctttc cccaccaccc tcccagcagg gctcacccag ggaaggggag
     1081 cggagggttg gcacagccag tgtccttcaa ccagtgaaga aacgcaaagt ggacatgccc
     1141 atcaccgtgt cctatgccat ctcagggcag ccagtggcca ccgtgctggc cattccacaa
     1201 ggccagcaac agagttacgt gtctttgagg ccagacttac tgacagtaga cagtgcccac
     1261 ctgtacagcg ccactgggac cataactagc cctacaggag aaacttggac catccctgtt
     1321 tattccgccc agccccgggg ggaccctcag cagcagagca ttacccacat tgccattccc
     1381 caggaagcct acaatgcagt tcacgtcagt ggctcaccca cggctctggc agctgtaaag
     1441 ctggaggatg acaaggagaa gatggtgggc accacatccg tagtgaagaa ctcccatgaa
     1501 gaggtagtgc agacccttgc aaactctctc tttccagcac agttcatgaa tggcaacatc
     1561 cacattccag tggctgtgca ggctgtagca ggcacgtacc agaatacggc tcagactgta
     1621 catatatggg acccacagca gcagccgcaa cagcaaactg cacaagaaca gacaccacca
     1681 cagccacagc aacagcagca gctgcaggtc acttgttcag cacaaactgt tcaggtcgct
     1741 gaagttgagc cacagtcaca accgcagcct tcaccagagc ttttgcttcc aaattcactg
     1801 aagccagaag aagggctaga agtatggaaa aactgggctc agaccaagaa tgctgaacta
     1861 gaaaaggatg ctcaaaacag attggccccc attgggaggc gccagttgct acgattccaa
     1921 gaagatctga tctcatctgc tgtggctgaa ttgaattatg gcctttgttt aatgacacga
     1981 gaagctcgga atggagaagg tgaaccctat gacccagatg tactctacta cattttcttg
     2041 tgtatacaga agtatctttt tgaaaatgga agagtagatg acatattctc tgatctttac
     2101 tatgttcgtt ttaccgaatg gctacatgaa gttctgaagg acgtgcagcc ccgggtcact
     2161 ccacttggct atgttctgcc cagccacgtg actgaagaga tgctgtggga atgcaagcag
     2221 cttggggcac attccccttc gacactgctg accaccctca tgttcttcaa caccaagtac
     2281 tttctgttga agacagtaga tcagcacatg aagctggcgt tctccaaggt cctccggcag
     2341 acaaagaaga gcccctcgaa tcctaaggat aaaagcacta gtatccgcta cctgaaggcc
     2401 ctcggaatac atcagactgg ccagaaagtt acagatgaca tgtatgcaga acagacagaa
     2461 aatccagaga acccattaag gtgtcccatc aagctctacg atttctacct cttcaaatgc
     2521 ccccagagtg tgaaaggccg aaatgacacc ttttacctga ctcctgagcc tgttgtggct
     2581 cccaacagcc cgatctggta ctcagtccag cctatcagcc gagagcagat gggacagatg
     2641 ctgacccgga tcctggttat acgagagatt caagaagcca ttgccgtggc caacgcaacc
     2701 accatgcact gaggtgcctc agccacagga aaaaaaaaaa tccaggaaaa accagacaga
     2761 cttttacact aaaggagagg cctccatttt tttctttttc tttttccttc aattcgtagt
     2821 tctaatgctt ttcaggcgac ttctgttaaa aatgtaaaag acaatgttgc cctctttgca
     2881 tcttcataaa atgggcagac cccctggttc atgggtatat ggttttccta gaacttgatg
     2941 tcctaggaag tggttggctt ttacctttct tttccttttt tttcttttgt ctgggctgga
     3001 gtgtggggga agggacttgg actgtatgga gaaatatagg cccttccctt cctcaaggca
     3061 gatggagcag ccgatgaatc aaccctcctg caaaccccca cctttcactc tggaccggca
     3121 ggcttaacca ctcggagcca cgatttttct tttttttttt tttttttttt tttttaaatg
     3181 ctcagacata aacttagcat cttgatggaa taaaaatgag gggaacttca attatgattt
     3241 ttattaaaga caatttctat tacacccttc tttatgacaa gtgacataga tgttaaagta
     3301 aaaactttac catgcttttt tttttttttt tttttttttt tggcctaaca ttgaggcctt
     3361 aaacctgagg ctcctgtgcc tgatggaatt cttgtaacat acacttgtgt atcatataaa
     3421 gataccactc tttctcttat gtattcttat tctagttgtt tattaagaat gacaagcacg
     3481 tcttttcaac aa
//
LOCUS       NM_001436478            1875 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436478 XM_017595579
VERSION     NM_001436478.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1875)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1875)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1875)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_017595579.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1249460.1,
                                           SRR22399492.1295932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  99544152-99544332   c
            182-228             JAXUCZ010000008.1  99539758-99539804   c
            229-296             JAXUCZ010000008.1  99536696-99536763   c
            297-410             JAXUCZ010000008.1  99533558-99533671   c
            411-497             JAXUCZ010000008.1  99532310-99532396   c
            498-578             JAXUCZ010000008.1  99530685-99530765   c
            579-604             JAXUCZ010000008.1  99528916-99528941   c
            605-693             JAXUCZ010000008.1  99528426-99528514   c
            694-795             JAXUCZ010000008.1  99527621-99527722   c
            796-884             JAXUCZ010000008.1  99526363-99526451   c
            885-1057            JAXUCZ010000008.1  99525667-99525839   c
            1058-1142           JAXUCZ010000008.1  99524785-99524869   c
            1143-1875           JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1875
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..181
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Morf4l1"
                     /note="upstream in-frame stop codon"
     CDS             142..1227
                     /gene="Morf4l1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 3"
                     /protein_id="NP_001423407.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKNAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLK
                     YVDANLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGD
                     GGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQ
                     LFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFE
                     RPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLK
                     YLAKNSATLFSASDYEVAPPEYHRKAV"
     misc_feature    184..468
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    184..468
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,412..414,
                     418..429,433..441,448..453)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,412..414,
                     418..429,433..441,448..453)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,412..414)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,412..414)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,295..297,412..423)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,295..297,412..423)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,295..297,421..423)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,295..297,421..423)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    664..1191
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    664..1191
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     exon            182..228
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..296
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..410
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..497
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..578
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..604
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..693
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..795
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..884
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1057
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1142
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1875
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggcgct ggcaaatcgc gcccaggatg tagagctggc tgttcccgac ggcgcgtctg
       61 acgctaaatt gggtggggta gagagtaggg ggcggtagtc gggggtggtg ggagaaggag
      121 gaggcggcga atcacttata aatggcgccc aagcaggacc cgaagcctaa attccaggag
      181 ggcgagcgag tgctgtgctt tcatgggcct cttctttatg aagcaaagtg tgtaaaggtt
      241 gccataaagg acaaacaagt gaagtatttt atccattaca gtggctggaa taaaaatgct
      301 gtgaggccca ggcgctctga aaaatctttg aagacacgtg aggatattgt agcccttttt
      361 cctgttcctg aaggagctcc ctcagtacac caccccctcc tgacctctag ttgggatgaa
      421 tgggtgccag aaagcagagt gctcaaatac gtggacgcca atttgcagaa acagcgggaa
      481 cttcaaaagg ccaaccagga acaatatgca gagggcaaga tgagaggggc tgctccaggg
      541 aagaagacat ccggtctgca acagaaaaat gttgaagtga aaacaaaaaa gaacaaacag
      601 aaaacacctg gaaatggaga tggtggcagt accagtgaga cccctcagcc tcctaggaag
      661 aagcgagccc gggtagatcc aaccgttgaa aatgaagaaa cattcatgaa cagagttgaa
      721 gttaaagtga agattcctga ggagctgaaa ccatggcttg tagatgactg ggacttgatc
      781 accagacaaa agcagctttt ttatcttcct gccaagaaga atgtggattc cattttggag
      841 gattatgcaa actataagaa gtctcgagga aatacagata ataaggagta tgctgttaat
      901 gaggttgtgg cagggataaa ggagtacttc aatgtaatgt tgggcactca gctactctac
      961 aaatttgaga gaccacagta tgctgaaatt ctggccgatc acccggatgc acccatgtcc
     1021 caggtgtatg gagcgccaca cttactgaga ttgtttgtgc gaattggagc gatgttggcc
     1081 tatacacctc tagatgagaa aagccttgct ttattactga actatctaca tgatttcctc
     1141 aagtacctgg caaagaattc tgcaactctg ttcagtgcca gtgattatga agtggctcct
     1201 cctgagtacc atcggaaagc cgtgtgagga gtgtgctctc tcactcgtgc ttggatctct
     1261 gtaaacagtt tggttcttag tccttctctt gtacaaatga tgtactttga agaccgttag
     1321 tgtataacag agttgatgtt tgtttcctgt ttgattttaa acagagaaaa taaaaggagt
     1381 taactgctcc ttttttcttt ctttttttca tttcaaagtt tctaccagtg tatcagtgat
     1441 ggacaacgga gagacatgct gtagagtgtt tgcctagttg acaaagctgc ttttgaatgc
     1501 tggtggttct gttcctttga cactacgcac ttttataata tgtgttaatg ctctatgaca
     1561 aaatgctctg actcctagtg ccaaaggttc ccttcagtgt gtataactga acactcatcc
     1621 atctgtgctc tttttttttt taaatggtgc ttaaagagcc catcctttgc aagtcatcca
     1681 tgttgttcct taggcatttt atctttgctc aattgttaaa gaatggtggc ttgttttcat
     1741 ggtttttgta tttgtgtcta atgcacgttt taacatgata gacgcaatgc atcgtgtagc
     1801 tacagtttta tggaaaagtc aatcttgtag gagttgtttt tcagatcttc aataaatttt
     1861 ttctttaaat ttcaa
//
LOCUS       NM_001436507            3997 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 4, mRNA.
ACCESSION   NM_001436507 XM_063265441
VERSION     NM_001436507.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3997)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 3997)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3997)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 3997)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 3997)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 3997)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265441.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.30086.1,
                                           SRR26360186.2001766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1017            JAXUCZ010000008.1  58249615-58249694
            1018-1166           JAXUCZ010000008.1  58254695-58254843
            1167-1294           JAXUCZ010000008.1  58256533-58256660
            1295-1390           JAXUCZ010000008.1  58258205-58258300
            1391-1614           JAXUCZ010000008.1  58266333-58266556
            1615-1685           JAXUCZ010000008.1  58267575-58267645
            1686-1914           JAXUCZ010000008.1  58268925-58269153
            1915-2106           JAXUCZ010000008.1  58271693-58271884
            2107-2246           JAXUCZ010000008.1  58273167-58273306
            2247-2425           JAXUCZ010000008.1  58276058-58276236
            2426-2504           JAXUCZ010000008.1  58276347-58276425
            2505-2584           JAXUCZ010000008.1  58277395-58277474
            2585-2708           JAXUCZ010000008.1  58277966-58278089
            2709-2904           JAXUCZ010000008.1  58279354-58279549
            2905-3997           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..3997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3997
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3080
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     4"
                     /protein_id="NP_001423436.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQV
                     IYMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLESSSPKSCSQNAEGSFSSPEDAL
                     PNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNC
                     ISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYNDIS
                     VTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVELR
                     QYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCLSS
                     EHAVIAKEQTAQAIANTAHAYEKSGVEAALSEAFHEEYSRLYQLAKETPTSHSDPRLQ
                     HVLVYFFQNEAPKRVVERTLLEQFADRNLSYDERSISIMKVAQAKLMEIGPEDMNMEE
                     YKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKE
                     SVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDL
                     DAIEVMRNHWCSYLGKDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLC
                     SRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    591..1886
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..1886
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1740..1742,1794..1796)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1740..1742,1794..1796)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    2238..3077
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2238..3077
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1166
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1390
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1614
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1685
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1914
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2106
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2246
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2425
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2504
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2584
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2708
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2904
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3997
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacag caatcccagg actaaatctg
      961 aaaaccccat ggtgcagctg ttctacggta ccttcctgac agaaggggtc cgagaaggaa
     1021 aacccttttg taacaacgag accttcggcc agtaccctct tcaggtaaac ggttaccaca
     1081 acttagacga gtgtttggaa ggggccatgg tggaaggtga cattgcgctg cttccttctg
     1141 atcgctcagt gaaatacgga caagagcgtt ggtttacaaa gctgcctcca gtgttgacct
     1201 tcgaactctc cagatttgag tttaatcagt ctcttgggca gcctgagaaa attcataata
     1261 agctggaatt tcctcaggtt atttatatgg ataggtacat gtacaaaagc aaagagctta
     1321 tccgaagtaa gagagagagc attcgaaagt tgaaggagga aatacaagtt ctgcagcaga
     1381 aattagaaag ttcaagtccc aaaagctgct ctcagaatgc tgagggttcc ttttcctctc
     1441 cggaagatgc tctacccaac tctgaggtaa tgaatgggcc atttacttct cctcactctt
     1501 ccctggaaat gcctgcaccc ccaccagctc ctcggacagt cacagatgag gaaatgaatt
     1561 tcgttaagac ctgtcttcag aggtggcgga gtgaaattga acaggatata caagacttaa
     1621 agaattgtat ctcgagcacc acccaggcta ttgagcagat gtactgtgat cctcttcttc
     1681 gtcaggtgcc ttatcgctta catgcagttc ttgttcatga aggacaagcc agtgcagggc
     1741 actactgggc gtacatctat aaccagcccc ggcagatctg gctcaaatac aacgacatct
     1801 ctgtcactga gtcttcctgg gaagaacttg aaagagattc ttacgggggc ctgagaaatg
     1861 tcagcgcata ctgcttgatg tatatcaatg acaagttgcc ccactgcagt gcagaggcag
     1921 cgcatggtga atctgatcag actgcagaag tggaagccct gtctgtggaa ctcaggcagt
     1981 acattcagga agataactgg aggtttgagc aagaggtgga ggaatgggag gaagaacagt
     2041 cctgtaagat cccacagatg gagtcctccc caaactcttc ctcacaggat ttttccacat
     2101 cacaagagtc ttcagcagcg tcctcgcatg gcgttcgatg tttgtcttct gaacatgctg
     2161 tgattgcaaa ggagcagact gcccaggcca tcgcaaacac ggctcatgcc tatgagaaga
     2221 gcggggtaga agcagccttg agtgaggcat ttcatgaaga gtactccagg ctctatcagc
     2281 ttgccaaaga gacacccacc tctcacagtg atcctcgcct tcagcatgtt ctcgtctact
     2341 ttttccaaaa tgaagcaccc aagagggtag tagaacgaac ccttctggaa cagtttgcag
     2401 atagaaacct tagctatgat gagagatcta tcagtatcat gaaggtggct caggccaaac
     2461 tgatggaaat tggtccagag gacatgaaca tggaagagta taagaggtgg catgaagact
     2521 atagtctgtt ccgaaaggtg tctgtgtacc tgctaacggg cctggaactc ttccaaaaag
     2581 gaaagtacca ggaagctttg tcctacctgg tgtacgcgta ccagagcaat gctggcctgc
     2641 tggtgaaggg gccccgcagg ggcgtgaagg agtctgtgat tgctttgtac cgcagaaaat
     2701 gccttctgga gttgaatgcc aaggctgctt ctctttttga aacaaatgac gaccattctg
     2761 taacagaggg cattaatgtg atgaatgagc tgatcattcc ctgcatccac ctgatcatta
     2821 ataatgacat ttccaaggac gaccttgatg ccatcgaggt catgaggaac cactggtgct
     2881 cttacctggg gaaggacatc gcagaaaatc tgcagctgtg tttaggggag ttcctaccca
     2941 ggcttctaga tccttccgca gaaatcatcg tcctaaagga gcctccaact attcgaccga
     3001 attctcccta tgatctttgc agccggtttg cagctgtcat ggagtccatt caaggagttt
     3061 caacagtaac agtgaagtaa actgcacatg gacggtcaag actcattttg gtctccagtc
     3121 acctgccagt tacacggcag tctgttgttg cagactcccc tggagagaga gattgggtgt
     3181 ctgagcaaga tttagaccct ctgccctctc tgatatgtgt ttaagggatt aaggataaag
     3241 ttgcgcattt aggtacagaa tcatgagagc tctctcactg aagaaggcag gagcccggtg
     3301 cattaaggtt ttgaattatc ccagaagacc tgaattgcct ttttaaatct cccataataa
     3361 ttacccttcg ggcgcctgtc tcatcagaac tgagccggag gaacagtttc tggttctttt
     3421 gtcaagttca ggtgacgttt ctaagtcctt agctaccaga gattggcaac aggggccttg
     3481 cctggctctt gacagtaaca caaagggtgc tgctgagcct ttccctccac acaagggtag
     3541 agcgtaaggc ttcgcccacc atgaagccac aggaaagctg cctccatttt cggtctgttt
     3601 atatttcaga taaaccagaa aacctcacac tcagtcttga gtgaaagaga agcaagcatc
     3661 ctgggctctc accccagtgc tggtgtaaag ctgcacaagg gacatttaat agctaattaa
     3721 gcaacattgt ggagattgtc acatgcaggt gtctaaggct acctggcctg atagaatttt
     3781 gattctctct ttcctttttt tttttttaga aataagggat gtgaatttat atagagagag
     3841 accatctatc tgtgtatatg tagagaagct gctttttaaa gaacttttaa ttgggaattc
     3901 atgttttaac aaaattttaa ggattaacga ggaatcatgg gagggaagaa cacaactatg
     3961 cagattttat aaatgtgcaa taaaagtatt tgtttta
//
LOCUS       NM_001011999            1761 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 5, mRNA.
ACCESSION   NM_001011999 XM_217222
VERSION     NM_001011999.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001011999.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078910.1, FQ226047.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  99544152-99544332   c
            182-228             JAXUCZ010000008.1  99539758-99539804   c
            229-296             JAXUCZ010000008.1  99536696-99536763   c
            297-383             JAXUCZ010000008.1  99532310-99532396   c
            384-464             JAXUCZ010000008.1  99530685-99530765   c
            465-490             JAXUCZ010000008.1  99528916-99528941   c
            491-579             JAXUCZ010000008.1  99528426-99528514   c
            580-681             JAXUCZ010000008.1  99527621-99527722   c
            682-770             JAXUCZ010000008.1  99526363-99526451   c
            771-943             JAXUCZ010000008.1  99525667-99525839   c
            944-1028            JAXUCZ010000008.1  99524785-99524869   c
            1029-1761           JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1761
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..181
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Morf4l1"
                     /note="upstream in-frame stop codon"
     CDS             142..1113
                     /gene="Morf4l1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 5"
                     /protein_id="NP_001011999.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKNWDEWVPESRVLKYVDANLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQ
                     QKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKI
                     PEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVV
                     AGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAY
                     TPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV"
     misc_feature    184..354
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    184..354
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,298..300,
                     304..315,319..327,334..339)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,298..300,
                     304..315,319..327,334..339)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,298..300)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,298..300)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,295..309)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,295..309)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,295..297,307..309)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,295..297,307..309)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    370..570
                     /gene="Morf4l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYU1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    421..822
                     /gene="Morf4l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYU1.1);
                     Region: Sufficient for interaction with SIN3A.
                     /evidence=ECO:0000250"
     misc_feature    451..453
                     /gene="Morf4l1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBU8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYU1.1); acetylation site"
     misc_feature    514..714
                     /gene="Morf4l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYU1.1);
                     Region: Interaction with RB1-1. /evidence=ECO:0000250"
     misc_feature    550..1077
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    550..1077
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    586..1050
                     /gene="Morf4l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYU1.1);
                     Region: Sufficient for interaction with PHF12.
                     /evidence=ECO:0000250"
     misc_feature    991..1056
                     /gene="Morf4l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYU1.1);
                     Region: Interaction with RB1-2. /evidence=ECO:0000250"
     exon            182..228
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..296
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..383
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..464
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..490
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..579
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..681
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..770
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..943
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1028
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1761
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggcgct ggcaaatcgc gcccaggatg tagagctggc tgttcccgac ggcgcgtctg
       61 acgctaaatt gggtggggta gagagtaggg ggcggtagtc gggggtggtg ggagaaggag
      121 gaggcggcga atcacttata aatggcgccc aagcaggacc cgaagcctaa attccaggag
      181 ggcgagcgag tgctgtgctt tcatgggcct cttctttatg aagcaaagtg tgtaaaggtt
      241 gccataaagg acaaacaagt gaagtatttt atccattaca gtggctggaa taaaaattgg
      301 gatgaatggg tgccagaaag cagagtgctc aaatacgtgg acgccaattt gcagaaacag
      361 cgggaacttc aaaaggccaa ccaggaacaa tatgcagagg gcaagatgag aggggctgct
      421 ccagggaaga agacatccgg tctgcaacag aaaaatgttg aagtgaaaac aaaaaagaac
      481 aaacagaaaa cacctggaaa tggagatggt ggcagtacca gtgagacccc tcagcctcct
      541 aggaagaagc gagcccgggt agatccaacc gttgaaaatg aagaaacatt catgaacaga
      601 gttgaagtta aagtgaagat tcctgaggag ctgaaaccat ggcttgtaga tgactgggac
      661 ttgatcacca gacaaaagca gcttttttat cttcctgcca agaagaatgt ggattccatt
      721 ttggaggatt atgcaaacta taagaagtct cgaggaaata cagataataa ggagtatgct
      781 gttaatgagg ttgtggcagg gataaaggag tacttcaatg taatgttggg cactcagcta
      841 ctctacaaat ttgagagacc acagtatgct gaaattctgg ccgatcaccc ggatgcaccc
      901 atgtcccagg tgtatggagc gccacactta ctgagattgt ttgtgcgaat tggagcgatg
      961 ttggcctata cacctctaga tgagaaaagc cttgctttat tactgaacta tctacatgat
     1021 ttcctcaagt acctggcaaa gaattctgca actctgttca gtgccagtga ttatgaagtg
     1081 gctcctcctg agtaccatcg gaaagccgtg tgaggagtgt gctctctcac tcgtgcttgg
     1141 atctctgtaa acagtttggt tcttagtcct tctcttgtac aaatgatgta ctttgaagac
     1201 cgttagtgta taacagagtt gatgtttgtt tcctgtttga ttttaaacag agaaaataaa
     1261 aggagttaac tgctcctttt ttctttcttt ttttcatttc aaagtttcta ccagtgtatc
     1321 agtgatggac aacggagaga catgctgtag agtgtttgcc tagttgacaa agctgctttt
     1381 gaatgctggt ggttctgttc ctttgacact acgcactttt ataatatgtg ttaatgctct
     1441 atgacaaaat gctctgactc ctagtgccaa aggttccctt cagtgtgtat aactgaacac
     1501 tcatccatct gtgctctttt tttttttaaa tggtgcttaa agagcccatc ctttgcaagt
     1561 catccatgtt gttccttagg cattttatct ttgctcaatt gttaaagaat ggtggcttgt
     1621 tttcatggtt tttgtatttg tgtctaatgc acgttttaac atgatagacg caatgcatcg
     1681 tgtagctaca gttttatgga aaagtcaatc ttgtaggagt tgtttttcag atcttcaata
     1741 aattttttct ttaaatttca a
//
LOCUS       NM_001436495            5182 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 5, mRNA.
ACCESSION   NM_001436495 XM_063265382
VERSION     NM_001436495.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5182)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5182)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265382.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1991327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000008.1  38090030-38090098
            70-242              JAXUCZ010000008.1  38092744-38092916
            243-444             JAXUCZ010000008.1  38095209-38095410
            445-572             JAXUCZ010000008.1  38098165-38098292
            573-747             JAXUCZ010000008.1  38099310-38099484
            748-885             JAXUCZ010000008.1  38099986-38100123
            886-959             JAXUCZ010000008.1  38100738-38100811
            960-1044            JAXUCZ010000008.1  38101595-38101679
            1045-1225           JAXUCZ010000008.1  38102404-38102584
            1226-1334           JAXUCZ010000008.1  38103121-38103229
            1335-1461           JAXUCZ010000008.1  38103788-38103914
            1462-1524           JAXUCZ010000008.1  38104180-38104242
            1525-1604           JAXUCZ010000008.1  38105285-38105364
            1605-1651           JAXUCZ010000008.1  38105453-38105499
            1652-1709           JAXUCZ010000008.1  38106236-38106293
            1710-1884           JAXUCZ010000008.1  38106533-38106707
            1885-1991           JAXUCZ010000008.1  38108447-38108553
            1992-2115           JAXUCZ010000008.1  38110471-38110594
            2116-2195           JAXUCZ010000008.1  38111060-38111139
            2196-2410           JAXUCZ010000008.1  38111280-38111494
            2411-2681           JAXUCZ010000008.1  38111574-38111844
            2682-2894           JAXUCZ010000008.1  38112380-38112592
            2895-3662           JAXUCZ010000008.1  38114925-38115692
            3663-3769           JAXUCZ010000008.1  38118990-38119096
            3770-3905           JAXUCZ010000008.1  38119994-38120129
            3906-5182           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5182
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..69
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            70..242
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    84..86
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             108..4031
                     /gene="Nfrkb"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 5"
                     /protein_id="NP_001423424.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEATLDL
                     QEKFSFEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKH
                     HEKRKHQPDHPDLLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKK
                     IKLIKSEAEDLAEPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFF
                     SLLLEILLLESQASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGES
                     RVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDA
                     MTPVPRVTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDK
                     ETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDV
                     TSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKA
                     RKALQQKPKPPSKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPALP
                     TPISPPPVSAVSRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQTT
                     ARVVSHSSSAGLPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKVV
                     PQAVVATVPVKGQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSAST
                     TAVIQNVTGQNIIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDA
                     KGQTVLRITPDMMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADS
                     PAKAPSASVPSSAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVASS
                     EAKPAATIRIVQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINATV
                     SKTVAVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMK
                     GKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQG
                     QATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1317..1574
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1317..1574
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2184..2798
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2184..2798
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3120..>3656
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    <3120..>3656
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            243..444
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            445..572
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            573..747
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            748..885
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..959
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1044
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1225
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1334
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1461
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1524
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1604
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1651
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1709
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1884
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1991
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2115
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2195
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2410
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2681
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2894
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3662
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..3769
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3905
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..5182
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggagcga gcgcgtccgg gagcccacgg ccggacgagc cccgggtgag acccgcggac
       61 ccggctgagg gtgtattttt aggtagtgta cctgtggaga agaaacaatg gattccttgg
      121 atcacatgct gacagatccc ctagaacttg gtccttgtgg agatggtcac agtacaggga
      181 tcatggagga ctgccttctg ggtggaacca gggttagtct gcctgaagac ctgctggagg
      241 atcctgaaat attctttgac gtcgtcagcc tctccacatg gcaggaagta ctaagtgact
      301 ctcagcgtga acatctccag cagtttctgc cgcagtttcc tacagacact gtagagcagc
      361 agaatgagct catccttgcc ctattcagtg gggagaactt ccgcttcgga aaccctctgc
      421 acatcgccca gaagctcttc cgagatggac actttaaccc tgaggtggtc aagtatcggc
      481 agctctgctt caagtcacag tacaagcggt acctcagctc ccaacagcag tatttccacc
      541 ggctgctgag acagattctt gcttccagaa gtgatctcct ggagatggct cgcacgagcg
      601 gcccggctct tccctttcga cacaagcacc attcaccatc ccgaagcccg gaggagcggg
      661 agtggcggac ccagcagcgt tacctgaaag tcttgaggga agtgaaggag gagtgtggcg
      721 acactgccct gtcgtctgat gaggaggcca cgttggattt acaagaaaaa ttttcttttg
      781 aagatctcag ctcatggctt ccaagctctc cagcacgctc tcctagtcct gcggtgcccc
      841 tgagggtggt gcccacgctt tccaccacgg atatgaaaac tgcagataaa atagaactgg
      901 gggacagtga cctgaagtta atgttaaaga aacaccatga gaagcggaaa catcaaccag
      961 atcacccaga ccttttgaca ggggatctga ctctcagcga catcatgact cgagtaaatg
     1021 ccggcaggaa gggctctcta gcagccttgt atgatttggc tgttcttaaa aaaaaggtga
     1081 aggaaaagga ggagaagaaa aagaagaaaa taaagttgat taaatcggag gcagaggatc
     1141 tggctgagcc cctaagcaat actgaagggg tcccaacgct ctcccaggcc ccctctcccc
     1201 tggcaatatc gtctatcaag gaagaacccc tggaagacat caagccttgt cttggaatca
     1261 atgaaatatc ttccagtttt ttctctcttc tgttagagat cttgctgctg gagagtcagg
     1321 ctagccttcc tatgctggag gaccgggttt tggattggca gtcttctcca gccagctccc
     1381 tcaacagctg gttctctgct gcccccaact gggctgagtt ggtgttgcct gctctgcagt
     1441 atcttgctgg agaaagccga gttccttcca gtttttctcc atttgttgaa ttcaaagaga
     1501 aaacccagca gtggaaattg cttggtcaat ctcaagataa tgaaaaggaa ttagccgctc
     1561 tcttccactt gtggctagaa accaaagacc aggctttctg taagcaggaa aatgaagaca
     1621 gctcagatgc catgacacct gtgcctcgag taactgacta tgtggttcgg cctagcacag
     1681 gagaggagaa acgggttttt caagagcagg agcgttacag gtatagccaa ccccataagg
     1741 cattcacctt tcgcatgcat ggctttgagt ctgtggtggg gccagtgaag ggcgtgtttg
     1801 acaaggagac ctccctcaac aaggctcgtg agcactcact gctgcgctct gaccggcctg
     1861 cctatgtcac cattctgtct cttgttcggg atgctgcggc tcggctgcct aatggagaag
     1921 gcactcgggc agagatctgt gagctgctca aggactctca gtttcttgct cctgatgtca
     1981 ccagcactca ggtgaacacg gtagtgagtg gcgcactgga tcgattgcat tatgagaagg
     2041 acccttgtgt gaaatacgac attggtcgga agctgtggat ctacctgcat cgtgaccgga
     2101 gtgaggaaga gtttgaacgg atccatcaag ctcaagcagc agcagctaaa gccagaaaag
     2161 ctcttcagca aaaacccaaa ccgccatcca aggtgaagtc cagtaataag gagggctccg
     2221 tgaagggcct tagtggtcct tctgagccca gccagatgag cctcagtgac tccagcatgc
     2281 cacctacccc agttacgcct gtaaccccca ccacgccagc attgcctacc cctatctctc
     2341 ctccacctgt gtcagcggtg agcagaagtg gctctaccac tgtctctgag ccagccaagt
     2401 ctagttcagg tgttcttctg gtgtcctcac caacaatgcc acagctagga acgatgcttt
     2461 cccctgcttc catccagact ccgcccagtt ctcagaccac tgctcgggtt gtcagccatt
     2521 ccagctcagc aggactgccc caggttcggg tagtagccca gcccagcctt cctgctgttt
     2581 cccagcagtc agtagggcca gcacagccac taccccagat gccagcagga ccacagatcc
     2641 gtgtgccagt caccgctacc caaaccaaag tagtacccca ggcagttgtg gctacagttc
     2701 cagtcaaggg gcagactaca gcggcctctg tgcaacggcc tggacctgca cagacaggac
     2761 ttacagtgac gagtcttcct gctgcagtta gccccgggag caagacagcc atgagttctc
     2821 ctgggagctc tgctccaagt gcctccacaa ccgccgtcat tcagaatgtc acaggacaga
     2881 acatcatcaa gcaggtgtca atcactggac agcttggtgt gaagccccag acaggcaaca
     2941 gcattccact cacagccaca aacttccgta tccagggtaa agatgtactg cgcctgccgc
     3001 cttcttccat caccacagat gccaagggcc agacggttct gagaatcact ccagacatga
     3061 tggccacact ggccaagtct caggtcacca cagtcaagtt gactcaggac ctctttgggg
     3121 caggtagcgg cactgcaggc aaaggcatct ctgctacctt gcatgtgact tccaaccctg
     3181 tccatgcggc tgacagccct gccaaggccc cttcagccag tgttccttca tcagctccag
     3241 cgggcactac cgtggtcaaa gtaactcctg atctcaagcc aacagaaacc tccagttcag
     3301 cttttcgctt gatgccagct cttggcgtga gtgtggcaga tcagaagggg aagaacacag
     3361 tggcctcttc agaagcaaaa cctgctgcca caatccgcat tgtgcagggg ctgggagtga
     3421 tgcctcctaa agcaggccag accattactg ttgcagcaca tgcaaagcaa ggagcctctg
     3481 ttgctggtgg gtctggaact gtccattctt caactgtgtc cttacccagt atcaatgcca
     3541 ctgtgtctaa gactgtggct gtggcttctg gagcaacaag cacccccatc agcatcggga
     3601 ctggagcccc caccgtgcga caggttcctg ttaacactac agttgtgtcc acatcccagt
     3661 ctgggaagct gcctaccagg atcacagttc ctctctctgt gattagccag ccaatgaagg
     3721 gcaagagcgt ggtcacagcc cccatcatca aaggcaacct tggagccaat ctcagtgggc
     3781 tgggtcgcaa catcatcctc acaaccatgc cagcgggtgc taagctcatt gctggcaata
     3841 agccagtgag tttcctcacc gcccagcagt tgcagcagct tcagcagcaa ggtcaggcta
     3901 cacaggtacg catccagact gtgccagcat cccatctgca acagggcaca gcttccggct
     3961 cctccaaagc cgtgtccact gttgttgtga ccacagctcc atctcctaaa caagcacctg
     4021 agcagcagtg actgagaaga aaggcggctt ctttaagaga ccaggcctgg tttatctcgg
     4081 ctgacagaaa gggagcaggg aggctgcacc attcttctga gctgtcctgc ttgaggcagg
     4141 gtggtggaga gtgatggcaa ctgtggccta gattgtgctg ccacactcca gagtgaagcc
     4201 ctttttaggg ttccagggat gatctgttat cctggactac caggaagagg gaaggaacat
     4261 cagagtctgg ggaggtcaca gtcacacaag ccggggttac ctcctgaatg ttgggttccc
     4321 agggagcagg cctgccagtt ggtgagtgga ccggcaggga ataagcctca ttctgtgtga
     4381 ggattttact ttttagtttc tgatcttctc cgtgacttgt tgagatgtga gttttgtgtc
     4441 cagagaattt ttgtgtaact tattttttta aagaacctac tctacgtctt ttatcaaata
     4501 gaaacctggg cttcagtgcc cctaaactga tcacttaccc cttcaaccag aatgagagca
     4561 tagcaagact cttaatagtt tggcggctta cttgataatg gagaggttat atagtaagaa
     4621 aatgtaggcc ttgagttagc atggaccccc tcaagtggga ctagttcaat gccgtgtact
     4681 aaatatgggc atctgaatct cggttgtccc tatgtcttct cttgtgggca ttgtccttga
     4741 caagcctgtt catggaagtt cagagctttt ggacaggagt aggggaagat gaggtgctgc
     4801 tctcaccgtg cacttgctta cagcccagac attgcacatt ctccttgctg tagaacagcc
     4861 attgctaacc agacccttgg agctggccac ttgactggga cagagaagaa atggggaggt
     4921 gggggcaggg gtaggcactg cctggcagtg ccatcttgag gggaaaggat gtttttattc
     4981 tggccatttc atatttctca gccaccacca gccacagaca gggctcagaa gggtacttta
     5041 caaagtccaa gtacttaatg tactaggtgt atcttaacgt gtcttgctgt ggtgcagggg
     5101 tgggtaggaa aacctttctg cagggatagt gcttccctgt ctctttgtga aaatatccaa
     5161 attattaaaa acatatcttt aa
//
LOCUS       NM_001436519            6374 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 38
            (Zbtb38), transcript variant 6, mRNA.
ACCESSION   NM_001436519 XM_063265580
VERSION     NM_001436519.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6374)
  AUTHORS   Miotto,B., Chibi,M., Xie,P., Koundrioukoff,S., Moolman-Smook,H.,
            Pugh,D., Debatisse,M., He,F., Zhang,L. and Defossez,P.A.
  TITLE     The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common
            fragile site stability
  JOURNAL   Cell Rep 7 (2), 575-587 (2014)
   PUBMED   24726359
REFERENCE   2  (bases 1 to 6374)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   3  (bases 1 to 6374)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 6374)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
REFERENCE   5  (bases 1 to 6374)
  AUTHORS   Kiefer,H., Chatail-Hermitte,F., Ravassard,P., Bayard,E., Brunet,I.
            and Mallet,J.
  TITLE     ZENON, a novel POZ Kruppel-like DNA binding protein associated with
            differentiation and/or survival of late postmitotic neurons
  JOURNAL   Mol Cell Biol 25 (5), 1713-1729 (2005)
   PUBMED   15713629
  REMARK    GeneRIF: ZENON is involved in the maintenance of panneuronal
            features and/or in the survival of mature neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265580.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.46012.1,
                                           SRR26643296.22667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  106175373-106175553 c
            182-6374            JAXUCZ010000008.1  106161802-106167994 c
FEATURES             Location/Qualifiers
     source          1..6374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..6374
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
     exon            1..181
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="upstream in-frame stop codon"
     exon            182..6374
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..3793
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zenon; zinc finger protein expressed in neurons;
                     zinc finger transcription factor Kaiso"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001423448.1"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQE
                     TVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTN
                     GPRITNAFSIIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTL
                     AEHSYAVSSITEAYRSQPLREHDSSSSSGKTGKENGEALTTKAKPCRKPKTQTQDSDS
                     TTENMPLPLVTCPEVNQERSPQPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAA
                     EVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQIC
                     MRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRIGELSSAGSALSDADHMV
                     KFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIW
                     HTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYR
                     LLPMRCKRAPYKSYRNSSYESAQGNRQRNESPPDTFVIPNLPSSEMPTLNFQDGRNSL
                     TSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQALKTDLVDSAEVSISSIGNSVSTTL
                     QAEPVCVSSGEHSASVISYSGSVPSVIVHSSQFSSVIKHSNAIACLANSNHQSPSQPV
                     ASPSLIKDSKPEADKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLGGSSGKTT
                     NVVEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGR
                     KPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNY
                     KPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELDRCAEVKL
                     PPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHLTLKPYICELCAKQFQSSS
                     TLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETL
                     KIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKICKTAAA
                     LRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDSEDSDQKDDIKKPLLKMSFE"
     misc_feature    224..565
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    224..565
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    569..571
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3; propagated from
                     UniProtKB/Swiss-Prot (Q5EXX3.1); phosphorylation site"
     misc_feature    869..1183
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1076..1747
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Interaction with CBFA2T3.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3"
     misc_feature    1103..1384
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1103..1384
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1208..1270
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1208..1270
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1208..1210,1217..1219,1256..1258,1268..1270)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1208..1210,1217..1219,1256..1258,1268..1270)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1295..1354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1295..1354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1562..1624
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1562..1624
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1562..1564,1571..1573,1610..1612,1622..1624)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1562..1564,1571..1573,1610..1612,1622..1624)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1577..1579,1583..1585,1589..1591,1595..1600,
                     1607..1612,1619..1621,1661..1663,1667..1669,1679..1684,
                     1691..1696,1703..1705,1745..1747,1751..1753,1757..1759,
                     1763..1768,1775..1780)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1577..1579,1583..1585,1589..1591,1595..1600,
                     1607..1612,1619..1621,1661..1663,1667..1669,1679..1684,
                     1691..1696,1703..1705,1745..1747,1751..1753,1757..1759,
                     1763..1768,1775..1780)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1730..1786
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1730..1786
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1922..2113
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2372..2509
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2750..2827
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2864..2923
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3236..3298
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3236..3298
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3236..3238,3245..3247,3284..3286,3296..3298)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3236..3238,3245..3247,3284..3286,3296..3298)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3251..3253,3257..3259,3263..3265,3269..3274,
                     3281..3286,3293..3295,3335..3337,3341..3343,3353..3358,
                     3365..3370,3377..3379,3419..3421,3425..3427,3431..3433,
                     3437..3442,3449..3454,3461..3463)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3251..3253,3257..3259,3263..3265,3269..3274,
                     3281..3286,3293..3295,3335..3337,3341..3343,3353..3358,
                     3365..3370,3377..3379,3419..3421,3425..3427,3431..3433,
                     3437..3442,3449..3454,3461..3463)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3275..3346
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3275..3346
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3314..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3314..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3320..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3320..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3404..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3404..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3443..>3499
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3443..>3499
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3488..3550
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3488..3550
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3581..3643
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3581..3643
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3695..3790
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 atgactatga gcaaatgtac tgcaaggatg tgtgtgggat ggcggagcca gctccctgca
       61 gcaaaccgtc ctttgtcaga aaatttccac agggcctcgc agccccacac agtggaccct
      121 ccttccatag gcctgcgcta gccggatatg gaatgggagt ttgacttttg caggattcca
      181 gatgacagtc atgtccctct ccagggacct caaggacgac tttcacagtg acacggtgct
      241 ctccatccta aatgagcagc gcattcgggg catcttatgt gatgtcacca tcattgtgga
      301 ggacaccaag tttaaagccc acagcaatgt cctggccgcc tcaagccttt atttcaaaaa
      361 catcttttgg agccatacga tctgtatttc cagtcatgtc ctagagctgg atgatctgaa
      421 agccgaagtg tttacagaga ttcttaatta catctacagc tccaccgtgg tggtcaggag
      481 acaggaaacc gtcactgacc ttgcagctgc agggaaaagg ctgggaatat cattcttaga
      541 ggaccttagt gaccgcaact tctcaaattc cccaggtcct tacgtagttt gcatcactga
      601 aaagggcgtg gttaaagaag aaaaaaatga aaaaaggcac gaagagccag ctgtcactaa
      661 tgggcccagg atcacaaacg cattttccat cattgagacg gaaaatagca atagcatgtt
      721 ttctcccctg gacttgaggg caagcttcaa aaaagtgtca gatgccatga gaaccactag
      781 cctttgccag gagagagcca gtgtctgccc cgaggcagag cctgtccgca cgcttgccga
      841 acactcatat gccgtttctt ccatcactga ggcctacagg agtcagcctc tgagggaaca
      901 tgacagcagc agttcatctg gtaaaacggg aaaagaaaat ggcgaagctc tcaccacaaa
      961 agcaaagcca tgccgaaagc caaagaccca aacccaggat tctgactcaa ccacagagaa
     1021 catgccactc cctctagtaa cctgcccaga ggtgaatcaa gaaagaagcc cacagccagc
     1081 tccaattctg tcacactcag aacctcccag cagtgaagga gatgtccatt ttcccagaga
     1141 agatgaaaac cagccctctg agactcctgg tcccccagca gcagaggtcc cgcccctcgt
     1201 ttataattgt agctgctgct ccaaatcctt cgacagcagc acactgctcg gggcccacat
     1261 gcagctgcac aagccgacgc aggacccctt tgtgtgcaag tactgcaaca agcagttcac
     1321 caccctcaac aggctggacc ggcacgagca gatctgcatg aggtcgagcc acatgcccat
     1381 gccaggagga aaccaaccct tcttagaaaa ctaccccacc attggacaag atggaggttc
     1441 attcacaagc ccagattcat tggtgccaga aagtaggatt ggtgaactat ccagcgctgg
     1501 gagtgccttg tcagacgcgg accacatggt gaaatttgtg aatgggcaga tgctttacag
     1561 ctgcgttgtg tgcaaacgta gctatgtgac tttgtccagc ctccggaggc acgcaaatgt
     1621 ccactcgtgg agaagaacgt acccttgtca ttactgcaac aaggtcttcg cactggctga
     1681 gtacaggaca cgacatgaga tctggcacac tggagagagg cggtaccagt gcattttctg
     1741 tcttgaaacg tttatgacct actacatact gaaaaaccat cagaagtctt ttcatgccat
     1801 agatcacaga ctctccatca gtaaaaaaac agcaaatgga ggcttgaagc ccaccgtcta
     1861 cccatacaaa ctttacaggc tcttgcctat gagatgcaag cgggcacctt ataagagcta
     1921 ccggaattct tcctatgaaa gtgctcaagg aaaccgtcaa aggaatgaat ccccacctga
     1981 caccttcgtc attccgaatc tgccaagctc tgaaatgccc acactgaact tccaagatgg
     2041 cagaaactcg ttgaccagca gccctgccat cccagtggaa acaccttcat ggcagggtac
     2101 acccacttct gccaaagtaa aaaatgcaga aggcctcaaa tggaggaagc aggcactgaa
     2161 aaccgatctc gtcgattcgg ctgaggtgtc gatttcttcc attggaaact ctgtcagcac
     2221 caccctgcag gcagagcccg tgtgtgtttc gagtggggag cactcggcct ccgtgatcag
     2281 ctacagcggc tcggtgccct ctgtcattgt gcacagcagc cagttctcgt cggtgatcaa
     2341 gcacagcaat gccattgcct gcctggccaa cagcaaccac cagtcccctt cacagcctgt
     2401 ggcgagtccg tccctgatca aggatagcaa gcctgaggca gataaagcca gtaaactcgc
     2461 aagcagaccc aaaaactcta aggagaaaaa gaaaaccgtt ccatgtaaca ggggagaaat
     2521 aacagaggag gcaaaatatg ttgctgatct cggaggatct tcgggcaaaa ccacaaatgt
     2581 cgtcgaagaa accagtaaga ttgaaactta tatagcaaaa cccgctctgc ccggcacctc
     2641 cacaaatagc aatgttgcac ccctttgcca aataacagtg aaaattggga acgaagccat
     2701 cgtgaaaagg catatccttg ggtctaagct gttttacaaa agagggagaa aacccaagta
     2761 tcaaatgcag gaagagacat tgcctcggga gagtgacccc gaaacccgtg gagacagccc
     2821 tcttgggctc tgccaagctg actgtgtgga gatgagtgaa gcatttgatg aagtgagtga
     2881 ccaggactcc accgataagc cgtggcgccc atactacaac tacaagccca agaagaaatc
     2941 caaacagtta agaaaaataa ggaaagtcaa gtggaggaag gaacgaggga gcagaagccc
     3001 cgtgggtcgg cgcaggtatc cagctgagct ggatcgcgca gagatgggtc ggcgcaggta
     3061 cccagctgaa ctagatcgct gcgcagaggt gaaattgccc ccagataagg cctctgaaga
     3121 agaggagaat aaagagatgc ccaagctgca gtgcgagctc tgtgacggtg acaaagcagc
     3181 aggggcggga gccgaaggca agccccacca gcatctcact ctgaagcctt acatctgcga
     3241 gctctgtgcg aagcagttcc agagctcctc cacgctcaag atgcacatga gatgccacac
     3301 tggcgagaag ccctaccagt gcaagacctg tgggcggcgc ttctcagtgc agggcaacct
     3361 acagaagcac gagcgcattc acctgggcgt gaaggagttc atctgtcagt attgtaacaa
     3421 ggctttcacg ctgaacgaga cactcaagat ccacgaaaga atccacacag gggagaagcg
     3481 ttaccactgt cagttctgct ttcagggttt cttatatctc tccacaaaaa ggaaccacga
     3541 gcggaggcat gtccgggagc atgacgggaa aggctttgct tgcttccagt gccccaaaat
     3601 atgcaaaaca gctgctgccc tcagaatgca ccaaaagaag cacttattca agaccttgac
     3661 taagcaagag gaaacagatg acctttgcca cgaaaactcc gatctcttgg agagtcaacc
     3721 ttgcactgat tcggaagaca gcgaccaaaa ggatgacata aaaaaacctt tgctgaaaat
     3781 gtcctttgag tgacaacagt tagaaaggtc ttcaaaattg tttgtgattt tttttatttt
     3841 tagtttttta agttttttta agcttagttt tgttcacata atattctcaa aggatggggg
     3901 gttgttaatt ttcctttgtg taaactcccc ccaaaaagga tcctaacaac tattttgggt
     3961 tttatcattc actctacaca gaatgcataa aaacaaacta gctgaatcct ctaacgaccg
     4021 agtattttgt gaaggctaat gaagttctga gctgtgggat tttgaacagt ggaaagagca
     4081 gctggatttt agcctaattt aagcctttct ctcgcgcact aatgaggtct gctgaactgt
     4141 tgttagtcac tggagagagt aagggtcagg atcgtgcaga tggcatcttt gagacatgct
     4201 aaacgagcta tgacagtatt tattgccatt gagtttctgc actattaatc tttggtaaac
     4261 tgatgggtat ttacaaaata tctaacaata taactgaaca tatgtaatgg gtaacctaaa
     4321 gtaggacatt ctcatatcac ctagagacac ttttctgcag cataaacctt gtaaagtacg
     4381 tatatgaatc actataacgt ttagctgtct gtctgtccct agtagagaac cacaagagca
     4441 atagacctca gataacacgg actgctgtag aaatcagtag aacatttgga atctggctga
     4501 cgagcatgtg tgtgcttctc gatggagtgc tgtgctgttc tcctgaagta tggctgagct
     4561 gttagttgaa ctggtccact caagtcacac agaacatagg tcatgcctta tctatgagaa
     4621 aaccttccta gacttacctg agattaccta tgccacacag tcctctgcag tggcctcacc
     4681 tcagaatgaa gaatgatcac attcttcaga actctgcagt cttccagtca tcccaaggcc
     4741 atggatgttg gggggctatc ccacccaact tctgtggtca aataatcctg gtccctccca
     4801 ttccactgaa gcagcagctg gaggctgagg gagagacaca cctctgtggt aatcaatctc
     4861 agtcccttgg aaaggccgaa agcctgattc ctcaggttta catctccttg gagctaatgc
     4921 agcacacagg tacatagtag tgaaaagggc cacagactcc ttacccccac tgataacatg
     4981 aggacagggg gacctgatgc ctccaacagc agcattgttt ttgagggatg gggagataga
     5041 atgtggaatg acagtgttct gccccttaca aacatgactc gaaacaccca caaagccaga
     5101 tgcccctcct tcgtgttcgc agacattagc tctctgttaa agccccactt ttacttctaa
     5161 atccttctaa atattgactc agactgtcaa cattgccctc aaaagtctcc ttgccctaca
     5221 ggtatttttt catgggaact agggtcctgg aaagctggaa ctcaaaagat tcttactgtt
     5281 aacactggca gaataggagg gagggagaac acagcctacc cttccagcac cagaatgggc
     5341 aaaactcaga acaggttaag tagtcgttcc cgctcgttgg attgagtagg tggaaagcca
     5401 aggctggaag gttatcagag gactctggtt tctcccaccc agtgttgtgt tgcctccacg
     5461 aagaaggctt agcatggttt ggggtaggca acatttaaac acccagaaaa aaggacatga
     5521 ttcaaggtga cctttatact gtagcacttt gctgttaccc ccaatatgta tctgcatttg
     5581 tcatttgttc atctcccttt acctacatac agtattatat agaggacatg gggaaacgca
     5641 agcaattgaa ctttgttttg tccattgtat atatgtgcac ccacaccatt tgagttttat
     5701 tgaagtagtc acaaagggct tatgaaaatc acttttgaat taataaccag atgacaagca
     5761 atcctgtgat ccactaatat gttttatctc agttatgatt ataaaacaat tatggattta
     5821 agttgttttg atttaactac aaataaagtt atatgtattg atgtctccca tcaatatgtg
     5881 gatatttttt aagtggactt gtatgctgat aattctagac caaagtaaat atggcagaat
     5941 atttatacat acaaataatt ttgcaaatat tttctataat tgtattattc atttaaaatg
     6001 ttgatagctt gtgttagttt cagggagggg gtgtatattt tgataaaata cttgactttg
     6061 taattctgta tattctatac aatttatagc agagccattt taagacaact ggttacattt
     6121 ttttgttgat tgtgtaaatg ttatgagtgg tgtttaagta tgcatcaagt acataatgac
     6181 caagtagaat taaagtgtaa acagtgaaca tactgtatgc tgtaaagata tattgtaact
     6241 tgctgttttt agcatctgta ttttggttag gaaatatgat taaatgcaga tgttaagggt
     6301 tggaaaggtc taattttatt tttagaaata atgaatataa atttgttttg cttgattaaa
     6361 atagctcatt ccta
//
LOCUS       NM_001436521            4322 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436521 XM_006242946
VERSION     NM_001436521.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4322)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4322)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4322)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4322)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4322)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4322)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4322)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006242946.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.44055.1,
                                           SRR26360176.1340131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1057           JAXUCZ010000008.1  57051767-57051799
            1058-1111           JAXUCZ010000008.1  57059041-57059094
            1112-1243           JAXUCZ010000008.1  57070067-57070198
            1244-4322           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4322
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1362
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 2 precursor"
                     /protein_id="NP_001423450.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DTTATTEPAVHGLTQLPNSAEELDSEDLSDSRAGEEGAIGAVDHAVIGGVVAVVVFAM
                     LCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1216..1272
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1216..1272
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1057
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1111
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..4322
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgacacca cggcgacgac agaaccagca gttcacggcc ttactcagtt gcccaattcc
     1081 gcagaagaac tggacagtga ggatctctca gattctcgag caggtgaaga gggcgccatt
     1141 ggggcagtgg accacgcggt gattggcggc gtcgtagccg tggtggtgtt tgccatgcta
     1201 tgtttgctca tcattctggg ccgctatttt gccagacata aaggtacata cttcactcat
     1261 gaagccaaag gagccgatga cgcagcagac gcagacacag ctataatcaa tgcagaagga
     1321 ggacagaaca actccgaaga aaagaaagag tacttcatct agatcagcct ttttgttcca
     1381 atgaggtgtc caacgggcct gcttagatga taaagagaca gtgatactgg aactttggag
     1441 aagctcgtgt ggtttttttt ttatgagtgg gtggaaagat gcgagactgg gaaggcttgg
     1501 gatttgcaat gtaaaaacaa agacaaaaaa tgttctttga aagtacgctc tgctgtttga
     1561 cacctctttt taatctggtt ttaatttggt ttgggttttg gtgttttcgt ttctatttcc
     1621 tcctaccaag tcaaacttgg gtacttggat ttggtttcgg tagattgcag aaaattctgt
     1681 gccttgtttt tcattcgttt gttgtgtttc tttccccttg ccctttttgt gcatttattt
     1741 ttcccaaaat caaatttgtt tttccccccc tcccaaacct cccatttttt ggaattgacc
     1801 tgctgggatt cctaagattc ccccccccac cccatttctg atttctttgt ttgtgttgac
     1861 ggtgactgct ttctgttcca aattcagttt cataaaagga aaaccagcac agtttagatt
     1921 tcatagttca gaatttagtg tctccatgat gcatccttct ctgttgtcgt aaagatttgg
     1981 gtgaactaaa aaaaaaaaag aaaaaaagaa aaaaaaaaga aaacaatgaa aactctttgc
     2041 tgctgcccat gtcttaaata cttagagcag cgaagactag aaacgtagac tgtgacccag
     2101 aagctgtcgt ctgctgtgga tcttcattac tgtacagggt tatctgcaag tgaggtgtgt
     2161 cgcaatgaga ttgaatttgt cgttaattct ttatctgtag gcggctcagt atagattacc
     2221 ccacgctgtg cagaacgggg gggggggggt tgtttttttt gttttttttt tttttttttt
     2281 tggagtggaa aggtctcctc cttcctcgtt gccctaaaca gatccgacag gtgaggtctg
     2341 tccgttttat gtaagtggac aaatttgaga tgccacagga ggggaggcag ggagggggaa
     2401 cgacagttct gctctggtta tttctactct ggacaatttc atccaccttt cccaattggc
     2461 cttactgctc gctgacgtgc aggagagagc aagtccatgt gttgtgtgag tgactgaagg
     2521 ggacagaatt tgtttaggtt tttttcccca cttttgtttt tgctttgggt ttttttcccc
     2581 tttgtgctta ttaaggaagg cagtgggatg tgtcctgtat gtactgtata ttacagacac
     2641 cgtcctgctg ggatttccac ctccagtccc tggctctgct ctcattcctt cagatttggc
     2701 ttgacaaagg caggaggtac aaaagaaggg ccggcattgt tctcgaaagg tcagagccaa
     2761 ggtggagaag cagcatgtag agattttcag ttacttaatc aaaactcaaa atgtgagtgt
     2821 ttctatcttt cctgcactag ccctggcctc tttcctcagc cttaagaacc atctgccaag
     2881 aactcctcat ctcgcatgat ggcagccata gtgcatagca actaaaataa gtttccgtga
     2941 acatatctta caccggagcc tgggggaagg tagaggagtg gaggaaccat ttgcattctc
     3001 tgaagctagg taggggtttg cagaagtgct gaggacatct agaagtagtt ctgaaggaca
     3061 aagcctaaac tattaccaca tgtgttggta agctccagac tccaaaactg tccctctggg
     3121 aagacggcac cagaaaagat agagctatct atatataaat atataaatat atattatata
     3181 acattttcag tcagtacttt tggattttgc aaggtgcatt tttactcttg ttacattatg
     3241 tggaaaactt atgctgattt atttaagggg aaaaaagtgt cgactctgtt atttgaaagg
     3301 atatttcttt ttcttgtctt cattttaact tctgatagaa ccactgcaat atgagggcct
     3361 tttgggaacg gactggtgtg taaaagaaaa ttcatcatcg agcagtgttt tgttaacccc
     3421 tctcctgccc ctaggcactt aaccaagaaa aaagccacaa ggaacatccc tttttcaaga
     3481 attttataat gtgcatctat tccgagccct tagcacccat cctgaccata gtgtgaccat
     3541 atcaaagggt gacaaccagt tagcatgtcg ttgaaagggt ttttcagctg ttctttttag
     3601 aaaaaaaata taaaaaatat taaaaaaaac taaaaataag caaacacaaa aaaactccca
     3661 ttgttcacag aattggcatc tcattttcgg gacagcccat ctttctgttt tgacaagtgt
     3721 acagtagtgc ggtgttctga tgtaacttta tggcttaaga tgttgacatg tctcaggttc
     3781 ctgtgtttcg attggtgttt ttccgtctca ggtagattgc aaagtgtagg ccccacacat
     3841 tggaaaaata ataataataa taataaataa taataataat aattaaacaa agcaaaaaca
     3901 ggaaattacg gattttagtt gtatattggt ttatgtattt ttcttaagta tacagtgcac
     3961 tgtttgaaat gtattgttga gtattacttt gtacaggttg atcacttttt ttagagtgaa
     4021 gaaagaacaa acttggtttt tttgtgtttt tttaaaggag tataaaataa tgaaggatgt
     4081 ataattgatg ccaaataagc ttgttcttta gtcacgatga cgtcttgttt tccctctagg
     4141 ccagttctgt ttctaaggtg tacaaggacc atgttacagt gtaagaaact ccacatccgt
     4201 gtgttccatt cgcattttgt atcggttcat gtataccatt tttacaaaaa gaaaaaagaa
     4261 aaaaaaaaga agtactataa aatatctgtc ttcttaataa aaaagattaa tgttacaagt
     4321 ga
//
LOCUS       NM_001012201            4412 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 1, mRNA.
ACCESSION   NM_001012201 XM_343385
VERSION     NM_001012201.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4412)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4412)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4412)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4412)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4412)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4412)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4412)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4412)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4412)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4412)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001012201.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2204347.1, BC078966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1114           JAXUCZ010000008.1  57041336-57041425
            1115-1147           JAXUCZ010000008.1  57051767-57051799
            1148-1201           JAXUCZ010000008.1  57059041-57059094
            1202-1333           JAXUCZ010000008.1  57070067-57070198
            1334-4412           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4412
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1452
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 1 precursor"
                     /protein_id="NP_001012201.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DPPTTIPPPTTTTTTTTTTTTTTTILTIITDTTATTEPAVHGLTQLPNSAEELDSEDL
                     SDSRAGEEGAIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADD
                     AADADTAIINAEGGQNNSEEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     163..1449
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /product="Cell adhesion molecule 1. /evidence=ECO:0000255.
                     /id=PRO_5004270763"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYP5.1)"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    229..231
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    331..333
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    367..369
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    523..525
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    940..942
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    952..954
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); glycosylation site"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1246..1308
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYP5.1);
                     transmembrane region"
     misc_feature    1306..1362
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1306..1362
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1387..1389
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8R5M8; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); phosphorylation site"
     misc_feature    1423..1425
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AYP5.1); phosphorylation site"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1147
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1201
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1333
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..4412
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgatcccc ccacaactat ccctcctccc acaacaacca ccaccaccac taccaccacc
     1081 accaccacca ccaccatcct taccatcatc acagacacca cggcgacgac agaaccagca
     1141 gttcacggcc ttactcagtt gcccaattcc gcagaagaac tggacagtga ggatctctca
     1201 gattctcgag caggtgaaga gggcgccatt ggggcagtgg accacgcggt gattggcggc
     1261 gtcgtagccg tggtggtgtt tgccatgcta tgtttgctca tcattctggg ccgctatttt
     1321 gccagacata aaggtacata cttcactcat gaagccaaag gagccgatga cgcagcagac
     1381 gcagacacag ctataatcaa tgcagaagga ggacagaaca actccgaaga aaagaaagag
     1441 tacttcatct agatcagcct ttttgttcca atgaggtgtc caacgggcct gcttagatga
     1501 taaagagaca gtgatactgg aactttggag aagctcgtgt ggtttttttt ttatgagtgg
     1561 gtggaaagat gcgagactgg gaaggcttgg gatttgcaat gtaaaaacaa agacaaaaaa
     1621 tgttctttga aagtacgctc tgctgtttga cacctctttt taatctggtt ttaatttggt
     1681 ttgggttttg gtgttttcgt ttctatttcc tcctaccaag tcaaacttgg gtacttggat
     1741 ttggtttcgg tagattgcag aaaattctgt gccttgtttt tcattcgttt gttgtgtttc
     1801 tttccccttg ccctttttgt gcatttattt ttcccaaaat caaatttgtt tttccccccc
     1861 tcccaaacct cccatttttt ggaattgacc tgctgggatt cctaagattc ccccccccac
     1921 cccatttctg atttctttgt ttgtgttgac ggtgactgct ttctgttcca aattcagttt
     1981 cataaaagga aaaccagcac agtttagatt tcatagttca gaatttagtg tctccatgat
     2041 gcatccttct ctgttgtcgt aaagatttgg gtgaactaaa aaaaaaaaag aaaaaaagaa
     2101 aaaaaaaaga aaacaatgaa aactctttgc tgctgcccat gtcttaaata cttagagcag
     2161 cgaagactag aaacgtagac tgtgacccag aagctgtcgt ctgctgtgga tcttcattac
     2221 tgtacagggt tatctgcaag tgaggtgtgt cgcaatgaga ttgaatttgt cgttaattct
     2281 ttatctgtag gcggctcagt atagattacc ccacgctgtg cagaacgggg gggggggggt
     2341 tgtttttttt gttttttttt tttttttttt tggagtggaa aggtctcctc cttcctcgtt
     2401 gccctaaaca gatccgacag gtgaggtctg tccgttttat gtaagtggac aaatttgaga
     2461 tgccacagga ggggaggcag ggagggggaa cgacagttct gctctggtta tttctactct
     2521 ggacaatttc atccaccttt cccaattggc cttactgctc gctgacgtgc aggagagagc
     2581 aagtccatgt gttgtgtgag tgactgaagg ggacagaatt tgtttaggtt tttttcccca
     2641 cttttgtttt tgctttgggt ttttttcccc tttgtgctta ttaaggaagg cagtgggatg
     2701 tgtcctgtat gtactgtata ttacagacac cgtcctgctg ggatttccac ctccagtccc
     2761 tggctctgct ctcattcctt cagatttggc ttgacaaagg caggaggtac aaaagaaggg
     2821 ccggcattgt tctcgaaagg tcagagccaa ggtggagaag cagcatgtag agattttcag
     2881 ttacttaatc aaaactcaaa atgtgagtgt ttctatcttt cctgcactag ccctggcctc
     2941 tttcctcagc cttaagaacc atctgccaag aactcctcat ctcgcatgat ggcagccata
     3001 gtgcatagca actaaaataa gtttccgtga acatatctta caccggagcc tgggggaagg
     3061 tagaggagtg gaggaaccat ttgcattctc tgaagctagg taggggtttg cagaagtgct
     3121 gaggacatct agaagtagtt ctgaaggaca aagcctaaac tattaccaca tgtgttggta
     3181 agctccagac tccaaaactg tccctctggg aagacggcac cagaaaagat agagctatct
     3241 atatataaat atataaatat atattatata acattttcag tcagtacttt tggattttgc
     3301 aaggtgcatt tttactcttg ttacattatg tggaaaactt atgctgattt atttaagggg
     3361 aaaaaagtgt cgactctgtt atttgaaagg atatttcttt ttcttgtctt cattttaact
     3421 tctgatagaa ccactgcaat atgagggcct tttgggaacg gactggtgtg taaaagaaaa
     3481 ttcatcatcg agcagtgttt tgttaacccc tctcctgccc ctaggcactt aaccaagaaa
     3541 aaagccacaa ggaacatccc tttttcaaga attttataat gtgcatctat tccgagccct
     3601 tagcacccat cctgaccata gtgtgaccat atcaaagggt gacaaccagt tagcatgtcg
     3661 ttgaaagggt ttttcagctg ttctttttag aaaaaaaata taaaaaatat taaaaaaaac
     3721 taaaaataag caaacacaaa aaaactccca ttgttcacag aattggcatc tcattttcgg
     3781 gacagcccat ctttctgttt tgacaagtgt acagtagtgc ggtgttctga tgtaacttta
     3841 tggcttaaga tgttgacatg tctcaggttc ctgtgtttcg attggtgttt ttccgtctca
     3901 ggtagattgc aaagtgtagg ccccacacat tggaaaaata ataataataa taataaataa
     3961 taataataat aattaaacaa agcaaaaaca ggaaattacg gattttagtt gtatattggt
     4021 ttatgtattt ttcttaagta tacagtgcac tgtttgaaat gtattgttga gtattacttt
     4081 gtacaggttg atcacttttt ttagagtgaa gaaagaacaa acttggtttt tttgtgtttt
     4141 tttaaaggag tataaaataa tgaaggatgt ataattgatg ccaaataagc ttgttcttta
     4201 gtcacgatga cgtcttgttt tccctctagg ccagttctgt ttctaaggtg tacaaggacc
     4261 atgttacagt gtaagaaact ccacatccgt gtgttccatt cgcattttgt atcggttcat
     4321 gtataccatt tttacaaaaa gaaaaaagaa aaaaaaaaga agtactataa aatatctgtc
     4381 ttcttaataa aaaagattaa tgttacaagt ga
//
LOCUS       NM_001014093            2314 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase family, member 16
            (Parp16), transcript variant 1, mRNA.
ACCESSION   NM_001014093 XM_236347
VERSION     NM_001014093.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Yang,D., Wang,Q., Wei,G., Wu,J., Zhu,Y.C., Zhu,Q., Ni,T., Liu,X.
            and Zhu,Y.Z.
  TITLE     Smyd3-PARP16 axis accelerates unfolded protein response and
            vascular aging
  JOURNAL   Aging (Albany NY) 12 (21), 21423-21445 (2020)
   PUBMED   33144524
  REMARK    GeneRIF: Smyd3-PARP16 axis accelerates unfolded protein response
            and vascular aging.
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2314)
  AUTHORS   Jwa,M. and Chang,P.
  TITLE     PARP16 is a tail-anchored endoplasmic reticulum protein required
            for the PERK- and IRE1alpha-mediated unfolded protein response
  JOURNAL   Nat Cell Biol 14 (11), 1223-1230 (2012)
   PUBMED   23103912
  REMARK    Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
REFERENCE   5  (bases 1 to 2314)
  AUTHORS   Di Paola,S., Micaroni,M., Di Tullio,G., Buccione,R. and Di
            Girolamo,M.
  TITLE     PARP16/ARTD15 is a novel endoplasmic-reticulum-associated
            mono-ADP-ribosyltransferase that interacts with, and modifies
            karyopherin-ss1
  JOURNAL   PLoS One 7 (6), e37352 (2012)
   PUBMED   22701565
REFERENCE   6  (bases 1 to 2314)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2314)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001014093.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085908.1, SRR26360186.1131707.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                JAXUCZ010000008.1  74626785-74626795
            12-294              JAXUCZ010000008.1  74627029-74627311
            295-432             JAXUCZ010000008.1  74633886-74634023
            433-639             JAXUCZ010000008.1  74636720-74636926
            640-811             JAXUCZ010000008.1  74640043-74640214
            812-953             JAXUCZ010000008.1  74642093-74642234
            954-2314            JAXUCZ010000008.1  74643248-74644608
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2314
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="poly (ADP-ribose) polymerase family, member 16"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
     exon            1..11
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            12..294
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1089
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 16; PARP-16;
                     ADP-ribosyltransferase diphtheria toxin-like 15; mono
                     [ADP-ribose] polymerase PARP16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP16"
                     /protein_id="NP_001014115.1"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
                     /translation="MQLSNRAAARESVSRDVLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQTWDLVSWILSSKILTIHSAEK
                     AEFEKIQQLTGAPHTPVPIPDFLFEIEYFDPANARFYETKGGRDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGRGWQHSLLGQTLSCVAVCEVI
                     DHPDVKCQTKKKDSKEIDRSRARIKHSEGGDVPPKYFVVTNNQLLRVKYLLVYSQKQP
                     KRASSQLSWLCSHWFMVAMSLYLLLLLIVSVTNSSAFQHFWNRLKR"
     misc_feature    163..390
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="ARTD15 N-terminal domain; Region: ARTD15_N;
                     pfam18084"
                     /db_xref="CDD:465641"
     misc_feature    163..390
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="ARTD15 N-terminal domain; Region: ARTD15_N;
                     pfam18084"
                     /db_xref="CDD:465641"
     misc_feature    424..939
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     Region: PARP; pfam00644"
                     /db_xref="CDD:395519"
     misc_feature    424..939
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     Region: PARP; pfam00644"
                     /db_xref="CDD:395519"
     misc_feature    697..699
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Nicotinamide-stacking aromate.
                     /evidence=ECO:0000250|UniProtKB:Q8N5Y8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Q4.1); other site"
     misc_feature    973..1035
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Q4.1);
                     transmembrane region"
     exon            295..432
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            433..639
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            640..811
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            812..953
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2314
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcccgga gctccacccc cgggctggga aacctggcag cagacggtcc aaggtccccc
       61 gggcccaggc cccgcactgc ccctccttgc ctcctcccga ccacgcgcta cgagcccggg
      121 atgcagctct ccaacagggc ggcagccagg gagtcggtga gccgcgacgt gctggccgcg
      181 gacctccgct gcagcctctt cgcctcagcg ctgcagagct acaagcggga ctcggtgctg
      241 cggcccttcc ccgcctccta cgcccgccac gactgtaagg acttcgaggc cctgcttgcg
      301 gacactggca ggttacctaa cttgaaggaa cttctgcagt cctccaggga cacagacaaa
      361 cagacctggg acctggtgag ctggattcta tcctccaaga tcctgacaat ccacagtgca
      421 gagaaggccg agtttgaaaa gatccagcag ctgaccggtg cacctcacac acctgtcccc
      481 atcccagatt tcctttttga aattgagtac tttgacccgg ccaatgccag attctatgag
      541 accaaaggag ggcgagacct gatctatgcc ttccatggca gccgcctaga gaacttccat
      601 tccatcattc acaacggcct gcattgtcac ctgaacaaga cttctctgtt tggagagggg
      661 acctacctca caagtgactt gagcctggcc ctcatttata gtcctcacgg ccgtgggtgg
      721 cagcatagcc tccttggcca gacccttagc tgtgtagctg tgtgtgaggt catcgaccat
      781 ccagatgtca agtgccaaac caagaagaag gattccaagg aaatcgaccg cagcagagct
      841 cgaatcaagc acagcgaagg gggagatgtc ccccctaagt actttgtagt cactaacaac
      901 cagcttctgc gggtgaagta cctactggtg tattcccaga agcagcccaa gagggcctcg
      961 agccagcttt cctggctgtg cagccattgg ttcatggtcg cgatgtccct ctatctgctg
     1021 ctgctgctca tcgtcagtgt caccaactcc tctgccttcc agcacttctg gaatcgcctg
     1081 aagagatgat ccctggtgct tggagtgggg ccactcaccg tgtgccttat gggcgctcgt
     1141 cctctacctc ctgcatgtca catccagtca ggtcgagtct gggaaccagt tgcggggtgc
     1201 acagggcgat gtttatatgc cataagtgta ctgattacct tgttggtgtg ctcagacaca
     1261 gtccagtcag cggggaccct ggcccctcac ttgctggctt caggggtatc ctaccatctg
     1321 cttcttccga aacagtctag ggaggtggct ctccagccag ggccaaagga agaagtcctg
     1381 ctgcatttaa aagcaaagtg tccaagctgt ccgcggtgtg tttgtaatag cccagatgga
     1441 ggcctcctga cgttaatgcc tctggaagac agaacatgtg caacgggaac gataaatcac
     1501 caggcggctg ccttgttttg actcaagaca cccaagaggg acagtcgtgt ttctcataaa
     1561 aatatcagtg ggaccgtttg ggaattccat cggctttagt ctgcgggtgc aaaacatttt
     1621 aacagttttc tcagatcaac aacagtctct gccacagctg tactcccctg cctcctcaac
     1681 cacacaggag gaggagccac aggcgggata acaaaatgca gatttgacaa ctagcaactc
     1741 tgtcatcttt ttctaaaaat gaccaactgc tgattacagc tcaaatggaa ccaaatgttt
     1801 gtgtttctgt ttctttgttg tttgtttgac caattagcct ctatgagcca aatagagagg
     1861 gagctgtgtg agccttgagc accgagtggc tggatccaca gcctctgtct ggttttgcta
     1921 tggagaaggg tccaagccat aggctcgcta gggtcctcat tcccacgaag ctgccttgat
     1981 aaacaacact ctaggctttc aggggccctg atggccttca aggcagaggc ctgcctcagt
     2041 gggccacaga tctccacagg ccgagcctct gtccaaggag cctgagcttg agttgaaagc
     2101 agagcccccc ggccgttcgt gctgtgttgt ttattctctc cttcctgcca gtcttcaatg
     2161 gcgaagaact ctgtctactg gcaatgggat ttccatagag aaggaggaaa tcatttttcc
     2221 ccctatgatt tgtaaagctt gtgaagaagc cactatcatg atttttaaac caagtagtga
     2281 gatgtttaaa aaccaataaa gatattttcc taaa
//
LOCUS       NM_001436472            4456 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 8,
            mRNA.
ACCESSION   NM_001436472 XM_063265179
VERSION     NM_001436472.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265179.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.45269.1,
                                           SRR26643297.29086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000008.1  84575422-84575749
            329-445             JAXUCZ010000008.1  84576190-84576306
            446-630             JAXUCZ010000008.1  84629460-84629644
            631-833             JAXUCZ010000008.1  84630342-84630544
            834-959             JAXUCZ010000008.1  84630809-84630934
            960-2772            JAXUCZ010000008.1  84632504-84634316
            2773-2886           JAXUCZ010000008.1  84636539-84636652
            2887-2966           JAXUCZ010000008.1  84638961-84639040
            2967-3075           JAXUCZ010000008.1  84640128-84640236
            3076-3234           JAXUCZ010000008.1  84641283-84641441
            3235-3303           JAXUCZ010000008.1  84645727-84645795
            3304-3500           JAXUCZ010000008.1  84647790-84647986
            3501-4456           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4456
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..328
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            329..445
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    355..357
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             430..3654
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 2 is encoded by transcript variant 8;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 2"
                     /protein_id="NP_001423401.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLRTTLKHSSVWRKHDFHS
                     LDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCLNIEAD
                     PGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTFCPTHL
                     TLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMFV
                     VVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRFQSSKS
                     GKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    3058..3231
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3058..3231
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3475..3648
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3475..3648
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            446..630
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            631..833
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            834..959
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2772
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2886
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2966
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3075
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3234
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3303
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3500
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..4456
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatgtgagc ggcccggcgg ccgcagagag cagtgccggg aggaggagcg
      181 aggggtcccg gagggcggcg agcgggcggg ctatgggagc cgttcccggg tgggcagaga
      241 cacgcgtggg tcggcgcggc tgaggacatg cccagactct gctgctgacc ggctccggct
      301 ggaacccggc tactgaagcc tcggcgagcg tttggaaaac gaagcagaag ccattgagtc
      361 agccgtgtgc cggttggaag aacccacacc tgtgttttac agcactttgg gtggaaattg
      421 gatgccaaaa tgaagccaga ccgagatgcc ttggatgagt attttgaata tgatgcagag
      481 gagttcttgg tctctttggc cttgctgata actgaaggcc gaacccctga gtgttccgtg
      541 aaaggccgtg cagagagttt ccactgccct ccagcgcagt ctcgtttccc aggcgcagcc
      601 agacatgagt gcagcgacaa gctggcccag tgtcgccaag ccagacgaac cagatctgag
      661 gtcacgctgt tgtggaaaaa taatcttcca atcatggtag aagtgatgct tctgccagat
      721 tgctgctaca gtgacgaggg ccctagcaca gaggggacag atctgaatga ccctgccatt
      781 aaacaagatg cactgttact ggagaggtgg atcttggagc cagttccccg acagaatggc
      841 gatcgcttca tcgaagagaa ggcacttctg ctggctgtca gatcattcgt gtttttttct
      901 cagttaagtg cttggctgag tgtttctcat ggtgctattc cacgaaacat tctttacaga
      961 atcagtgctg ctgatgtcga cctgcagtgg agtttttcac agactccaac tgagcatgtg
     1021 tttcccgttc ccaatgtctc tcacaacgtg gccttgaaag tcagcgttca gtccttaccc
     1081 agacaagctc attatccagt tttgacctgt agtatccata ctaatattgg tctgtatgag
     1141 aagagaattc aggaacagga gcttcgagcc tgtcagcacc gtggccctgg tgaagtggag
     1201 taccgttgtc ccagcagctc tcagagtctg tgcagcaagc acacatggac catggcacct
     1261 gtgagtgccc tgcatgtcag aagtggcatg cctcctgagt acactgcagc cattagaaat
     1321 gtcaggctct gcccaggcac aggtagcaag tctgacaatg gaacacctca agccagcgtc
     1381 ctgggcttca gtggcactgg agaagtgagg tcccaggagg catcagtgag aactttcaaa
     1441 tcactctctg tgatcgattc cagtgtctcc agctgtcaga gctcccggca gccagtaggg
     1501 gagcctaacc ctttaatcga ctccctgatt caggatcgac aagaagtcat tgccaggatt
     1561 gctcagcact tgattcactg tgaccccagc tcctctcgca tgtctgaact cccctttaac
     1621 accccagagt ccacttcact tagcccaaag cttcacccag tttcacagga gagtgggtat
     1681 tcgagaagat gcaaagaagc attctctgtc tcttttggga gtccagagtt tggctcccca
     1741 ggagacagca aggaggggaa agtgaaagag aagctggaaa ccaggcaagg agaaacctgt
     1801 gcctctcaca gtccctaccc tcggcagcct gctggggagg caaacccact gattggctct
     1861 ttgcttctgg agcggcagga tgtcatagcc aggatcgcac agcacttgga gcacatcgac
     1921 cccacagctc acattccccg gcctgcgttc agcaagcacg actccaattc cattccttct
     1981 aaagtgttca ggagttcatt tcatgacaaa accatgttga agaaggacag agagaatgtc
     2041 tctgtttctg ctactcatac agaagtgtcc ttattgggag acagaggtga tgggaaaagc
     2101 cccaaaccta gtaaatgttt ccgatctttc aaaaacagtc ctcaagaaaa gtctctgaaa
     2161 cctgaagaaa gcgctcagca tcagaaccat cctgatgaca tcacccacac agccaggcag
     2221 gagttgctga acaaggctgc tggcttactc acttcctcta actcgtccct ctgcaatgaa
     2281 agcagcttgg ctttgattgg cagattggaa agtacatctt gtaaattaca acttaggaag
     2341 caagaaatga gccatgaaac tgagaaacag tgtttgcatt gcaacagtat tgacaaacag
     2401 atttgcacaa ataaatgcac agagaaaata aaagatgaga atagcccggg ctctctcagt
     2461 catctccagt gtgatgagtc aagaggtatt gacccaaaaa taaaagtgac tatgttggaa
     2521 atgcctgact atttgaacaa gtacaaaact aattgttcaa ataaagactc caaaagatca
     2581 aagacatgtg agcaaaacat tcagcttggc acagaaaatt atctcagtga agatactgag
     2641 ggttccaaaa gcacaatatc agaccaacta aaaactgagc aggaggaaaa caaagattca
     2701 gttgccggaa aacctccaag tgtaaagcac tgtctgtcta caagcgaaag actgaaaaat
     2761 gcagacatgt tgaggactac actgaagcat tcaagtgtct ggaggaaaca cgattttcat
     2821 tccctggatg ggacatcaac cagagccttt catcctcaga cagggctgcc tctcctctca
     2881 agcccagttc ctcaaagaaa aacacagtca ggttgctttg atctagacac gtcactactg
     2941 catctgagaa gtctatcctc caaaagctct cgaccgtgtc tgaacattga agcggaccca
     3001 ggtgttcatg aaaagccttt tttgagttca agtgctccac caatcacaag tcttagtctc
     3061 ctagggaatt ttgaggaatc ggttctgaat taccgtttag accccctcgg catagttgat
     3121 ggcttcactg ctgaggtggg agccagtggg actttctgcc ctacgcactt gactctgccg
     3181 gtggaagtgt cgttctacag tgtttcggat gataacgctc cctcgcctta tatgggtgtg
     3241 attactttag agtcccttgg taaaaggggt tatcgagtac ctccttcagg aacgatacaa
     3301 gtgaccttat tcaatcccaa taagactgtg gtgaagatgt ttgttgtcgt gtatgaccta
     3361 cgaagtatgc cagccaatca ccagacattc ctgcggcaga ggacgttttc tgttcctgtt
     3421 aaacaagaaa tgaagagaag tattaacaaa gagaatgtcc agcacacggc acagttacta
     3481 cgctacctca tacacctgag gttccagagc tctaaatctg ggaagatcta cctccataga
     3541 gatgtccggc tcctgttctc tagaaagtcc atggaggttg atagcggtgc tgcttatgaa
     3601 ctcaagtctt acaccgaatc gccaacaaac ccacagtttt caccaagatg ctgataaggg
     3661 agacggatta aaagtatttg ctcagtaccc aagcttgaac gtgagcattc accgagtgga
     3721 atacatccaa tgagagccag tggagtggag tggccctcct cttgtcctgg accagatttt
     3781 attaaaggac ccctgaactg agacccatga ctcctaagtg gactggaagc acccctgtct
     3841 tcaccctttt cgtactgttg aaaccacttc attggacagt tgcaatagca aaatccccag
     3901 ttagattagt gtttacacat tttatttctg ttatttaata tttaatgttt tccttaatag
     3961 tcaagtgatg tttgtctcta gtgttctaat gtagcacaat ctatgtaaaa tcatactatg
     4021 tatttttgac attaatgttg aaattgaaat atatgcataa gtctttaatt ttgtgtggtg
     4081 tgttttaagt gctattcatt taagctactg aaaatgagaa tgaaatgttg ggcttcttta
     4141 agattaatgc actatgcaag catgtatgct tttgatatct ctccaggtta ggttttaaag
     4201 aactcaccag ggctgttccc aggggtccga caaagctgct cccatcctcc tggcaaacac
     4261 tcagcctcct gcccattctc atccttctaa gatccccccc accccaaaaa cattctattt
     4321 tccctgaatc actactgtag aggttttact ttaaattgct atcccatgct acataatttt
     4381 ctcacactgt taaaaagaat atgtactttg aaaagaattt aatatttata ttgtaaatat
     4441 atgcaaaaaa ctaaaa
//
LOCUS       NM_001436505            4177 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 2, mRNA.
ACCESSION   NM_001436505 XM_006243011
VERSION     NM_001436505.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4177)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4177)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4177)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4177)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4177)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4177)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243011.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB240643.1, SRR26643299.35001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1017            JAXUCZ010000008.1  58249615-58249694
            1018-1166           JAXUCZ010000008.1  58254695-58254843
            1167-1294           JAXUCZ010000008.1  58256533-58256660
            1295-1390           JAXUCZ010000008.1  58258205-58258300
            1391-1570           JAXUCZ010000008.1  58264169-58264348
            1571-1794           JAXUCZ010000008.1  58266333-58266556
            1795-1865           JAXUCZ010000008.1  58267575-58267645
            1866-2094           JAXUCZ010000008.1  58268925-58269153
            2095-2286           JAXUCZ010000008.1  58271693-58271884
            2287-2426           JAXUCZ010000008.1  58273167-58273306
            2427-2605           JAXUCZ010000008.1  58276058-58276236
            2606-2684           JAXUCZ010000008.1  58276347-58276425
            2685-2764           JAXUCZ010000008.1  58277395-58277474
            2765-2888           JAXUCZ010000008.1  58277966-58278089
            2889-3084           JAXUCZ010000008.1  58279354-58279549
            3085-4177           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4177
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3260
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     2"
                     /protein_id="NP_001423434.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQV
                     IYMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVI
                     EFASTKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPED
                     ALPNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLK
                     NCISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYND
                     ISVTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVE
                     LRQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCL
                     SSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEAFHEEYSRLYQLAKETPTSHSDPR
                     LQHVLVYFFQNEAPKRVVERTLLEQFADRNLSYDERSISIMKVAQAKLMEIGPEDMNM
                     EEYKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEALSYLVYAYQSNAGLLVKGPRRGV
                     KESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKD
                     DLDAIEVMRNHWCSYLGKDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYD
                     LCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    2418..3257
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2418..3257
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1166
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1390
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1570
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1794
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1865
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2094
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2286
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2426
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2605
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2684
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2764
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2888
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3084
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..4177
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacag caatcccagg actaaatctg
      961 aaaaccccat ggtgcagctg ttctacggta ccttcctgac agaaggggtc cgagaaggaa
     1021 aacccttttg taacaacgag accttcggcc agtaccctct tcaggtaaac ggttaccaca
     1081 acttagacga gtgtttggaa ggggccatgg tggaaggtga cattgcgctg cttccttctg
     1141 atcgctcagt gaaatacgga caagagcgtt ggtttacaaa gctgcctcca gtgttgacct
     1201 tcgaactctc cagatttgag tttaatcagt ctcttgggca gcctgagaaa attcataata
     1261 agctggaatt tcctcaggtt atttatatgg ataggtacat gtacaaaagc aaagagctta
     1321 tccgaagtaa gagagagagc attcgaaagt tgaaggagga aatacaagtt ctgcagcaga
     1381 aattagaaag gtatgtgaag tacggctccg gtccatctcg cttcccactc cccgacatgt
     1441 tgaaatacgt tattgaattt gccagtacaa aacctgcctc tgaaagctgt ctgtctggaa
     1501 gtgttgagca tatgacgtta ccacttcctt ctgtgcactg cccgatttct gacctcacag
     1561 ccaaggaaag ttcaagtccc aaaagctgct ctcagaatgc tgagggttcc ttttcctctc
     1621 cggaagatgc tctacccaac tctgaggtaa tgaatgggcc atttacttct cctcactctt
     1681 ccctggaaat gcctgcaccc ccaccagctc ctcggacagt cacagatgag gaaatgaatt
     1741 tcgttaagac ctgtcttcag aggtggcgga gtgaaattga acaggatata caagacttaa
     1801 agaattgtat ctcgagcacc acccaggcta ttgagcagat gtactgtgat cctcttcttc
     1861 gtcaggtgcc ttatcgctta catgcagttc ttgttcatga aggacaagcc agtgcagggc
     1921 actactgggc gtacatctat aaccagcccc ggcagatctg gctcaaatac aacgacatct
     1981 ctgtcactga gtcttcctgg gaagaacttg aaagagattc ttacgggggc ctgagaaatg
     2041 tcagcgcata ctgcttgatg tatatcaatg acaagttgcc ccactgcagt gcagaggcag
     2101 cgcatggtga atctgatcag actgcagaag tggaagccct gtctgtggaa ctcaggcagt
     2161 acattcagga agataactgg aggtttgagc aagaggtgga ggaatgggag gaagaacagt
     2221 cctgtaagat cccacagatg gagtcctccc caaactcttc ctcacaggat ttttccacat
     2281 cacaagagtc ttcagcagcg tcctcgcatg gcgttcgatg tttgtcttct gaacatgctg
     2341 tgattgcaaa ggagcagact gcccaggcca tcgcaaacac ggctcatgcc tatgagaaga
     2401 gcggggtaga agcagccttg agtgaggcat ttcatgaaga gtactccagg ctctatcagc
     2461 ttgccaaaga gacacccacc tctcacagtg atcctcgcct tcagcatgtt ctcgtctact
     2521 ttttccaaaa tgaagcaccc aagagggtag tagaacgaac ccttctggaa cagtttgcag
     2581 atagaaacct tagctatgat gagagatcta tcagtatcat gaaggtggct caggccaaac
     2641 tgatggaaat tggtccagag gacatgaaca tggaagagta taagaggtgg catgaagact
     2701 atagtctgtt ccgaaaggtg tctgtgtacc tgctaacggg cctggaactc ttccaaaaag
     2761 gaaagtacca ggaagctttg tcctacctgg tgtacgcgta ccagagcaat gctggcctgc
     2821 tggtgaaggg gccccgcagg ggcgtgaagg agtctgtgat tgctttgtac cgcagaaaat
     2881 gccttctgga gttgaatgcc aaggctgctt ctctttttga aacaaatgac gaccattctg
     2941 taacagaggg cattaatgtg atgaatgagc tgatcattcc ctgcatccac ctgatcatta
     3001 ataatgacat ttccaaggac gaccttgatg ccatcgaggt catgaggaac cactggtgct
     3061 cttacctggg gaaggacatc gcagaaaatc tgcagctgtg tttaggggag ttcctaccca
     3121 ggcttctaga tccttccgca gaaatcatcg tcctaaagga gcctccaact attcgaccga
     3181 attctcccta tgatctttgc agccggtttg cagctgtcat ggagtccatt caaggagttt
     3241 caacagtaac agtgaagtaa actgcacatg gacggtcaag actcattttg gtctccagtc
     3301 acctgccagt tacacggcag tctgttgttg cagactcccc tggagagaga gattgggtgt
     3361 ctgagcaaga tttagaccct ctgccctctc tgatatgtgt ttaagggatt aaggataaag
     3421 ttgcgcattt aggtacagaa tcatgagagc tctctcactg aagaaggcag gagcccggtg
     3481 cattaaggtt ttgaattatc ccagaagacc tgaattgcct ttttaaatct cccataataa
     3541 ttacccttcg ggcgcctgtc tcatcagaac tgagccggag gaacagtttc tggttctttt
     3601 gtcaagttca ggtgacgttt ctaagtcctt agctaccaga gattggcaac aggggccttg
     3661 cctggctctt gacagtaaca caaagggtgc tgctgagcct ttccctccac acaagggtag
     3721 agcgtaaggc ttcgcccacc atgaagccac aggaaagctg cctccatttt cggtctgttt
     3781 atatttcaga taaaccagaa aacctcacac tcagtcttga gtgaaagaga agcaagcatc
     3841 ctgggctctc accccagtgc tggtgtaaag ctgcacaagg gacatttaat agctaattaa
     3901 gcaacattgt ggagattgtc acatgcaggt gtctaaggct acctggcctg atagaatttt
     3961 gattctctct ttcctttttt tttttttaga aataagggat gtgaatttat atagagagag
     4021 accatctatc tgtgtatatg tagagaagct gctttttaaa gaacttttaa ttgggaattc
     4081 atgttttaac aaaattttaa ggattaacga ggaatcatgg gagggaagaa cacaactatg
     4141 cagattttat aaatgtgcaa taaaagtatt tgtttta
//
LOCUS       NM_001436480            1668 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 6, mRNA.
ACCESSION   NM_001436480 XM_063265206
VERSION     NM_001436480.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1668)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1668)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1668)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2330348.1,
                                           SRR26643293.46684.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000008.1  99543916-99544003   c
            89-135              JAXUCZ010000008.1  99539758-99539804   c
            136-203             JAXUCZ010000008.1  99536696-99536763   c
            204-290             JAXUCZ010000008.1  99532310-99532396   c
            291-371             JAXUCZ010000008.1  99530685-99530765   c
            372-397             JAXUCZ010000008.1  99528916-99528941   c
            398-486             JAXUCZ010000008.1  99528426-99528514   c
            487-588             JAXUCZ010000008.1  99527621-99527722   c
            589-677             JAXUCZ010000008.1  99526363-99526451   c
            678-850             JAXUCZ010000008.1  99525667-99525839   c
            851-935             JAXUCZ010000008.1  99524785-99524869   c
            936-1668            JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1668
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..88
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..135
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            136..203
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..290
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..371
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1020
                     /gene="Morf4l1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 6"
                     /protein_id="NP_001423409.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQP
                     PRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNV
                     DSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILAD
                     HPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLF
                     SASDYEVAPPEYHRKAV"
     misc_feature    457..984
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    457..984
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     exon            372..397
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..486
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..588
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..677
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..850
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..935
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1668
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgggta acttcagtgc gtcatttggc gacagtgctt cgtggcgcga aagcgagcct
       61 ccggcacagg caaagccgaa ggatccccgc gagcgagtgc tgtgctttca tgggcctctt
      121 ctttatgaag caaagtgtgt aaaggttgcc ataaaggaca aacaagtgaa gtattttatc
      181 cattacagtg gctggaataa aaattgggat gaatgggtgc cagaaagcag agtgctcaaa
      241 tacgtggacg ccaatttgca gaaacagcgg gaacttcaaa aggccaacca ggaacaatat
      301 gcagagggca agatgagagg ggctgctcca gggaagaaga catccggtct gcaacagaaa
      361 aatgttgaag tgaaaacaaa aaagaacaaa cagaaaacac ctggaaatgg agatggtggc
      421 agtaccagtg agacccctca gcctcctagg aagaagcgag cccgggtaga tccaaccgtt
      481 gaaaatgaag aaacattcat gaacagagtt gaagttaaag tgaagattcc tgaggagctg
      541 aaaccatggc ttgtagatga ctgggacttg atcaccagac aaaagcagct tttttatctt
      601 cctgccaaga agaatgtgga ttccattttg gaggattatg caaactataa gaagtctcga
      661 ggaaatacag ataataagga gtatgctgtt aatgaggttg tggcagggat aaaggagtac
      721 ttcaatgtaa tgttgggcac tcagctactc tacaaatttg agagaccaca gtatgctgaa
      781 attctggccg atcacccgga tgcacccatg tcccaggtgt atggagcgcc acacttactg
      841 agattgtttg tgcgaattgg agcgatgttg gcctatacac ctctagatga gaaaagcctt
      901 gctttattac tgaactatct acatgatttc ctcaagtacc tggcaaagaa ttctgcaact
      961 ctgttcagtg ccagtgatta tgaagtggct cctcctgagt accatcggaa agccgtgtga
     1021 ggagtgtgct ctctcactcg tgcttggatc tctgtaaaca gtttggttct tagtccttct
     1081 cttgtacaaa tgatgtactt tgaagaccgt tagtgtataa cagagttgat gtttgtttcc
     1141 tgtttgattt taaacagaga aaataaaagg agttaactgc tccttttttc tttctttttt
     1201 tcatttcaaa gtttctacca gtgtatcagt gatggacaac ggagagacat gctgtagagt
     1261 gtttgcctag ttgacaaagc tgcttttgaa tgctggtggt tctgttcctt tgacactacg
     1321 cacttttata atatgtgtta atgctctatg acaaaatgct ctgactccta gtgccaaagg
     1381 ttcccttcag tgtgtataac tgaacactca tccatctgtg ctcttttttt ttttaaatgg
     1441 tgcttaaaga gcccatcctt tgcaagtcat ccatgttgtt ccttaggcat tttatctttg
     1501 ctcaattgtt aaagaatggt ggcttgtttt catggttttt gtatttgtgt ctaatgcacg
     1561 ttttaacatg atagacgcaa tgcatcgtgt agctacagtt ttatggaaaa gtcaatcttg
     1621 taggagttgt ttttcagatc ttcaataaat tttttcttta aatttcaa
//
LOCUS       NM_001436523            4235 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 4, mRNA.
ACCESSION   NM_001436523 XM_006242948
VERSION     NM_001436523.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4235)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4235)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006242948.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.346839.1,
                                           SRR26360172.1934189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1156           JAXUCZ010000008.1  57070067-57070198
            1157-4235           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4235
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1275
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 4 precursor"
                     /protein_id="NP_001423452.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DSRAGEEGAIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDA
                     ADADTAIINAEGGQNNSEEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1129..1185
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1129..1185
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1156
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..4235
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgattctc gagcaggtga agagggcgcc attggggcag tggaccacgc ggtgattggc
     1081 ggcgtcgtag ccgtggtggt gtttgccatg ctatgtttgc tcatcattct gggccgctat
     1141 tttgccagac ataaaggtac atacttcact catgaagcca aaggagccga tgacgcagca
     1201 gacgcagaca cagctataat caatgcagaa ggaggacaga acaactccga agaaaagaaa
     1261 gagtacttca tctagatcag cctttttgtt ccaatgaggt gtccaacggg cctgcttaga
     1321 tgataaagag acagtgatac tggaactttg gagaagctcg tgtggttttt tttttatgag
     1381 tgggtggaaa gatgcgagac tgggaaggct tgggatttgc aatgtaaaaa caaagacaaa
     1441 aaatgttctt tgaaagtacg ctctgctgtt tgacacctct ttttaatctg gttttaattt
     1501 ggtttgggtt ttggtgtttt cgtttctatt tcctcctacc aagtcaaact tgggtacttg
     1561 gatttggttt cggtagattg cagaaaattc tgtgccttgt ttttcattcg tttgttgtgt
     1621 ttctttcccc ttgccctttt tgtgcattta tttttcccaa aatcaaattt gtttttcccc
     1681 ccctcccaaa cctcccattt tttggaattg acctgctggg attcctaaga ttcccccccc
     1741 caccccattt ctgatttctt tgtttgtgtt gacggtgact gctttctgtt ccaaattcag
     1801 tttcataaaa ggaaaaccag cacagtttag atttcatagt tcagaattta gtgtctccat
     1861 gatgcatcct tctctgttgt cgtaaagatt tgggtgaact aaaaaaaaaa aagaaaaaaa
     1921 gaaaaaaaaa agaaaacaat gaaaactctt tgctgctgcc catgtcttaa atacttagag
     1981 cagcgaagac tagaaacgta gactgtgacc cagaagctgt cgtctgctgt ggatcttcat
     2041 tactgtacag ggttatctgc aagtgaggtg tgtcgcaatg agattgaatt tgtcgttaat
     2101 tctttatctg taggcggctc agtatagatt accccacgct gtgcagaacg gggggggggg
     2161 ggttgttttt tttgtttttt tttttttttt ttttggagtg gaaaggtctc ctccttcctc
     2221 gttgccctaa acagatccga caggtgaggt ctgtccgttt tatgtaagtg gacaaatttg
     2281 agatgccaca ggaggggagg cagggagggg gaacgacagt tctgctctgg ttatttctac
     2341 tctggacaat ttcatccacc tttcccaatt ggccttactg ctcgctgacg tgcaggagag
     2401 agcaagtcca tgtgttgtgt gagtgactga aggggacaga atttgtttag gtttttttcc
     2461 ccacttttgt ttttgctttg ggtttttttc ccctttgtgc ttattaagga aggcagtggg
     2521 atgtgtcctg tatgtactgt atattacaga caccgtcctg ctgggatttc cacctccagt
     2581 ccctggctct gctctcattc cttcagattt ggcttgacaa aggcaggagg tacaaaagaa
     2641 gggccggcat tgttctcgaa aggtcagagc caaggtggag aagcagcatg tagagatttt
     2701 cagttactta atcaaaactc aaaatgtgag tgtttctatc tttcctgcac tagccctggc
     2761 ctctttcctc agccttaaga accatctgcc aagaactcct catctcgcat gatggcagcc
     2821 atagtgcata gcaactaaaa taagtttccg tgaacatatc ttacaccgga gcctggggga
     2881 aggtagagga gtggaggaac catttgcatt ctctgaagct aggtaggggt ttgcagaagt
     2941 gctgaggaca tctagaagta gttctgaagg acaaagccta aactattacc acatgtgttg
     3001 gtaagctcca gactccaaaa ctgtccctct gggaagacgg caccagaaaa gatagagcta
     3061 tctatatata aatatataaa tatatattat ataacatttt cagtcagtac ttttggattt
     3121 tgcaaggtgc atttttactc ttgttacatt atgtggaaaa cttatgctga tttatttaag
     3181 gggaaaaaag tgtcgactct gttatttgaa aggatatttc tttttcttgt cttcatttta
     3241 acttctgata gaaccactgc aatatgaggg ccttttggga acggactggt gtgtaaaaga
     3301 aaattcatca tcgagcagtg ttttgttaac ccctctcctg cccctaggca cttaaccaag
     3361 aaaaaagcca caaggaacat ccctttttca agaattttat aatgtgcatc tattccgagc
     3421 ccttagcacc catcctgacc atagtgtgac catatcaaag ggtgacaacc agttagcatg
     3481 tcgttgaaag ggtttttcag ctgttctttt tagaaaaaaa atataaaaaa tattaaaaaa
     3541 aactaaaaat aagcaaacac aaaaaaactc ccattgttca cagaattggc atctcatttt
     3601 cgggacagcc catctttctg ttttgacaag tgtacagtag tgcggtgttc tgatgtaact
     3661 ttatggctta agatgttgac atgtctcagg ttcctgtgtt tcgattggtg tttttccgtc
     3721 tcaggtagat tgcaaagtgt aggccccaca cattggaaaa ataataataa taataataaa
     3781 taataataat aataattaaa caaagcaaaa acaggaaatt acggatttta gttgtatatt
     3841 ggtttatgta tttttcttaa gtatacagtg cactgtttga aatgtattgt tgagtattac
     3901 tttgtacagg ttgatcactt tttttagagt gaagaaagaa caaacttggt ttttttgtgt
     3961 ttttttaaag gagtataaaa taatgaagga tgtataattg atgccaaata agcttgttct
     4021 ttagtcacga tgacgtcttg ttttccctct aggccagttc tgtttctaag gtgtacaagg
     4081 accatgttac agtgtaagaa actccacatc cgtgtgttcc attcgcattt tgtatcggtt
     4141 catgtatacc atttttacaa aaagaaaaaa gaaaaaaaaa agaagtacta taaaatatct
     4201 gtcttcttaa taaaaaagat taatgttaca agtga
//
LOCUS       NM_001436522            4358 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436522 XM_006242944
VERSION     NM_001436522.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4358)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4358)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4358)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4358)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4358)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4358)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4358)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4358)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4358)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4358)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006242944.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2151422.1,
                                           SRR26360172.682824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1114           JAXUCZ010000008.1  57041336-57041425
            1115-1147           JAXUCZ010000008.1  57051767-57051799
            1148-1279           JAXUCZ010000008.1  57070067-57070198
            1280-4358           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4358
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4358
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1398
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 3 precursor"
                     /protein_id="NP_001423451.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DPPTTIPPPTTTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGAIGAVDHAV
                     IGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNS
                     EEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1252..1308
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1252..1308
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1147
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1279
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..4358
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgatcccc ccacaactat ccctcctccc acaacaacca ccaccaccac taccaccacc
     1081 accaccacca ccaccatcct taccatcatc acagacacca cggcgacgac agaaccagca
     1141 gttcacgatt ctcgagcagg tgaagagggc gccattgggg cagtggacca cgcggtgatt
     1201 ggcggcgtcg tagccgtggt ggtgtttgcc atgctatgtt tgctcatcat tctgggccgc
     1261 tattttgcca gacataaagg tacatacttc actcatgaag ccaaaggagc cgatgacgca
     1321 gcagacgcag acacagctat aatcaatgca gaaggaggac agaacaactc cgaagaaaag
     1381 aaagagtact tcatctagat cagccttttt gttccaatga ggtgtccaac gggcctgctt
     1441 agatgataaa gagacagtga tactggaact ttggagaagc tcgtgtggtt ttttttttat
     1501 gagtgggtgg aaagatgcga gactgggaag gcttgggatt tgcaatgtaa aaacaaagac
     1561 aaaaaatgtt ctttgaaagt acgctctgct gtttgacacc tctttttaat ctggttttaa
     1621 tttggtttgg gttttggtgt tttcgtttct atttcctcct accaagtcaa acttgggtac
     1681 ttggatttgg tttcggtaga ttgcagaaaa ttctgtgcct tgtttttcat tcgtttgttg
     1741 tgtttctttc cccttgccct ttttgtgcat ttatttttcc caaaatcaaa tttgtttttc
     1801 cccccctccc aaacctccca ttttttggaa ttgacctgct gggattccta agattccccc
     1861 ccccacccca tttctgattt ctttgtttgt gttgacggtg actgctttct gttccaaatt
     1921 cagtttcata aaaggaaaac cagcacagtt tagatttcat agttcagaat ttagtgtctc
     1981 catgatgcat ccttctctgt tgtcgtaaag atttgggtga actaaaaaaa aaaaagaaaa
     2041 aaagaaaaaa aaaagaaaac aatgaaaact ctttgctgct gcccatgtct taaatactta
     2101 gagcagcgaa gactagaaac gtagactgtg acccagaagc tgtcgtctgc tgtggatctt
     2161 cattactgta cagggttatc tgcaagtgag gtgtgtcgca atgagattga atttgtcgtt
     2221 aattctttat ctgtaggcgg ctcagtatag attaccccac gctgtgcaga acgggggggg
     2281 gggggttgtt ttttttgttt tttttttttt tttttttgga gtggaaaggt ctcctccttc
     2341 ctcgttgccc taaacagatc cgacaggtga ggtctgtccg ttttatgtaa gtggacaaat
     2401 ttgagatgcc acaggagggg aggcagggag ggggaacgac agttctgctc tggttatttc
     2461 tactctggac aatttcatcc acctttccca attggcctta ctgctcgctg acgtgcagga
     2521 gagagcaagt ccatgtgttg tgtgagtgac tgaaggggac agaatttgtt taggtttttt
     2581 tccccacttt tgtttttgct ttgggttttt ttcccctttg tgcttattaa ggaaggcagt
     2641 gggatgtgtc ctgtatgtac tgtatattac agacaccgtc ctgctgggat ttccacctcc
     2701 agtccctggc tctgctctca ttccttcaga tttggcttga caaaggcagg aggtacaaaa
     2761 gaagggccgg cattgttctc gaaaggtcag agccaaggtg gagaagcagc atgtagagat
     2821 tttcagttac ttaatcaaaa ctcaaaatgt gagtgtttct atctttcctg cactagccct
     2881 ggcctctttc ctcagcctta agaaccatct gccaagaact cctcatctcg catgatggca
     2941 gccatagtgc atagcaacta aaataagttt ccgtgaacat atcttacacc ggagcctggg
     3001 ggaaggtaga ggagtggagg aaccatttgc attctctgaa gctaggtagg ggtttgcaga
     3061 agtgctgagg acatctagaa gtagttctga aggacaaagc ctaaactatt accacatgtg
     3121 ttggtaagct ccagactcca aaactgtccc tctgggaaga cggcaccaga aaagatagag
     3181 ctatctatat ataaatatat aaatatatat tatataacat tttcagtcag tacttttgga
     3241 ttttgcaagg tgcattttta ctcttgttac attatgtgga aaacttatgc tgatttattt
     3301 aaggggaaaa aagtgtcgac tctgttattt gaaaggatat ttctttttct tgtcttcatt
     3361 ttaacttctg atagaaccac tgcaatatga gggccttttg ggaacggact ggtgtgtaaa
     3421 agaaaattca tcatcgagca gtgttttgtt aacccctctc ctgcccctag gcacttaacc
     3481 aagaaaaaag ccacaaggaa catccctttt tcaagaattt tataatgtgc atctattccg
     3541 agcccttagc acccatcctg accatagtgt gaccatatca aagggtgaca accagttagc
     3601 atgtcgttga aagggttttt cagctgttct ttttagaaaa aaaatataaa aaatattaaa
     3661 aaaaactaaa aataagcaaa cacaaaaaaa ctcccattgt tcacagaatt ggcatctcat
     3721 tttcgggaca gcccatcttt ctgttttgac aagtgtacag tagtgcggtg ttctgatgta
     3781 actttatggc ttaagatgtt gacatgtctc aggttcctgt gtttcgattg gtgtttttcc
     3841 gtctcaggta gattgcaaag tgtaggcccc acacattgga aaaataataa taataataat
     3901 aaataataat aataataatt aaacaaagca aaaacaggaa attacggatt ttagttgtat
     3961 attggtttat gtatttttct taagtataca gtgcactgtt tgaaatgtat tgttgagtat
     4021 tactttgtac aggttgatca ctttttttag agtgaagaaa gaacaaactt ggtttttttg
     4081 tgttttttta aaggagtata aaataatgaa ggatgtataa ttgatgccaa ataagcttgt
     4141 tctttagtca cgatgacgtc ttgttttccc tctaggccag ttctgtttct aaggtgtaca
     4201 aggaccatgt tacagtgtaa gaaactccac atccgtgtgt tccattcgca ttttgtatcg
     4261 gttcatgtat accattttta caaaaagaaa aaagaaaaaa aaaagaagta ctataaaata
     4321 tctgtcttct taataaaaaa gattaatgtt acaagtga
//
LOCUS       NM_001436479            1800 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 4, mRNA.
ACCESSION   NM_001436479 XM_063265202
VERSION     NM_001436479.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265202.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.476268.1,
                                           SRR26643296.22625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  99544152-99544332   c
            182-267             JAXUCZ010000008.1  99539719-99539804   c
            268-335             JAXUCZ010000008.1  99536696-99536763   c
            336-422             JAXUCZ010000008.1  99532310-99532396   c
            423-503             JAXUCZ010000008.1  99530685-99530765   c
            504-529             JAXUCZ010000008.1  99528916-99528941   c
            530-618             JAXUCZ010000008.1  99528426-99528514   c
            619-720             JAXUCZ010000008.1  99527621-99527722   c
            721-809             JAXUCZ010000008.1  99526363-99526451   c
            810-982             JAXUCZ010000008.1  99525667-99525839   c
            983-1067            JAXUCZ010000008.1  99524785-99524869   c
            1068-1800           JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1800
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..181
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Morf4l1"
                     /note="upstream in-frame stop codon"
     CDS             142..1152
                     /gene="Morf4l1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 4"
                     /protein_id="NP_001423408.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKVWNLLSFEKVTKKCV
                     KVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDANLQKQRELQKANQEQYAEGKM
                     RGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENE
                     ETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRG
                     NTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHL
                     LRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRK
                     AV"
     misc_feature    184..393
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    184..393
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,310..312,316..327,337..339,
                     343..354,358..366,373..378)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,310..312,316..327,337..339,
                     343..354,358..366,373..378)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,316..318,325..327,337..339)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,316..318,325..327,337..339)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(307..309,313..330,334..348)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(307..309,313..330,334..348)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(307..309,316..318,328..330,334..336,346..348)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    order(307..309,316..318,328..330,334..336,346..348)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    589..1116
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    589..1116
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     exon            182..267
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..335
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..422
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..503
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..529
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..618
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..720
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..809
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..982
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1067
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1800
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggcgct ggcaaatcgc gcccaggatg tagagctggc tgttcccgac ggcgcgtctg
       61 acgctaaatt gggtggggta gagagtaggg ggcggtagtc gggggtggtg ggagaaggag
      121 gaggcggcga atcacttata aatggcgccc aagcaggacc cgaagcctaa attccaggag
      181 ggcgagcgag tgctgtgctt tcatgggcct cttctttatg aagcaaaggt atggaacctg
      241 ctttcttttg agaaggtgac caaaaagtgt gtaaaggttg ccataaagga caaacaagtg
      301 aagtatttta tccattacag tggctggaat aaaaattggg atgaatgggt gccagaaagc
      361 agagtgctca aatacgtgga cgccaatttg cagaaacagc gggaacttca aaaggccaac
      421 caggaacaat atgcagaggg caagatgaga ggggctgctc cagggaagaa gacatccggt
      481 ctgcaacaga aaaatgttga agtgaaaaca aaaaagaaca aacagaaaac acctggaaat
      541 ggagatggtg gcagtaccag tgagacccct cagcctccta ggaagaagcg agcccgggta
      601 gatccaaccg ttgaaaatga agaaacattc atgaacagag ttgaagttaa agtgaagatt
      661 cctgaggagc tgaaaccatg gcttgtagat gactgggact tgatcaccag acaaaagcag
      721 cttttttatc ttcctgccaa gaagaatgtg gattccattt tggaggatta tgcaaactat
      781 aagaagtctc gaggaaatac agataataag gagtatgctg ttaatgaggt tgtggcaggg
      841 ataaaggagt acttcaatgt aatgttgggc actcagctac tctacaaatt tgagagacca
      901 cagtatgctg aaattctggc cgatcacccg gatgcaccca tgtcccaggt gtatggagcg
      961 ccacacttac tgagattgtt tgtgcgaatt ggagcgatgt tggcctatac acctctagat
     1021 gagaaaagcc ttgctttatt actgaactat ctacatgatt tcctcaagta cctggcaaag
     1081 aattctgcaa ctctgttcag tgccagtgat tatgaagtgg ctcctcctga gtaccatcgg
     1141 aaagccgtgt gaggagtgtg ctctctcact cgtgcttgga tctctgtaaa cagtttggtt
     1201 cttagtcctt ctcttgtaca aatgatgtac tttgaagacc gttagtgtat aacagagttg
     1261 atgtttgttt cctgtttgat tttaaacaga gaaaataaaa ggagttaact gctccttttt
     1321 tctttctttt tttcatttca aagtttctac cagtgtatca gtgatggaca acggagagac
     1381 atgctgtaga gtgtttgcct agttgacaaa gctgcttttg aatgctggtg gttctgttcc
     1441 tttgacacta cgcactttta taatatgtgt taatgctcta tgacaaaatg ctctgactcc
     1501 tagtgccaaa ggttcccttc agtgtgtata actgaacact catccatctg tgctcttttt
     1561 ttttttaaat ggtgcttaaa gagcccatcc tttgcaagtc atccatgttg ttccttaggc
     1621 attttatctt tgctcaattg ttaaagaatg gtggcttgtt ttcatggttt ttgtatttgt
     1681 gtctaatgca cgttttaaca tgatagacgc aatgcatcgt gtagctacag ttttatggaa
     1741 aagtcaatct tgtaggagtt gtttttcaga tcttcaataa attttttctt taaatttcaa
//
LOCUS       NM_001376950            5011 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus immunoglobulin superfamily, member 9B (Igsf9b),
            transcript variant 2, mRNA.
ACCESSION   NM_001376950 XM_006226347 XM_006242739
VERSION     NM_001376950.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Woo,J., Kwon,S.K., Nam,J., Choi,S., Takahashi,H., Krueger,D.,
            Park,J., Lee,Y., Bae,J.Y., Lee,D., Ko,J., Kim,H., Kim,M.H.,
            Bae,Y.C., Chang,S., Craig,A.M. and Kim,E.
  TITLE     The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM
            to promote inhibitory synapse development
  JOURNAL   J Cell Biol 201 (6), 929-944 (2013)
   PUBMED   23751499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001376950.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000008.1  33971825-33972116
            293-490             JAXUCZ010000008.1  33982295-33982492
            491-637             JAXUCZ010000008.1  33984368-33984514
            638-789             JAXUCZ010000008.1  33989337-33989488
            790-907             JAXUCZ010000008.1  33989774-33989891
            908-1049            JAXUCZ010000008.1  33991152-33991293
            1050-1195           JAXUCZ010000008.1  33991471-33991616
            1196-1338           JAXUCZ010000008.1  33993926-33994068
            1339-1479           JAXUCZ010000008.1  33994369-33994509
            1480-1596           JAXUCZ010000008.1  33994600-33994716
            1597-1747           JAXUCZ010000008.1  33994965-33995115
            1748-1871           JAXUCZ010000008.1  33996000-33996123
            1872-2047           JAXUCZ010000008.1  33998544-33998719
            2048-2274           JAXUCZ010000008.1  34000145-34000371
            2275-2359           JAXUCZ010000008.1  34001143-34001227
            2360-2521           JAXUCZ010000008.1  34003269-34003430
            2522-2567           JAXUCZ010000008.1  34004163-34004208
            2568-4223           JAXUCZ010000008.1  34004745-34006400
            4224-4345           JAXUCZ010000008.1  34013702-34013823
            4346-5011           JAXUCZ010000008.1  34017028-34017693
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5011
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="immunoglobulin superfamily, member 9B"
                     /db_xref="GeneID:315510"
                     /db_xref="RGD:1564717"
     exon            1..292
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    199..201
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="upstream in-frame stop codon"
     CDS             229..4554
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein turtle homolog B"
                     /codon_start=1
                     /product="protein turtle homolog B isoform 2 precursor"
                     /protein_id="NP_001363879.1"
                     /db_xref="GeneID:315510"
                     /db_xref="RGD:1564717"
                     /translation="MIWYVATLIASVISTRGLVAQVAHGLREEPEFVTARAGEGVVLR
                     CDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQ
                     VRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMT
                     CTAFGNPKPIVTWLKEGTLLSASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAV
                     HTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDL
                     KLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI
                     YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEAL
                     GTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFP
                     VITWRKVGKPSRSKHNALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT
                     SPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSLSVPL
                     GPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVTPPRC
                     LTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEMLDDAIPGTDGEFFAKDLSQ
                     DTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAA
                     AILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPS
                     ESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISR
                     GPDGRFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKP
                     QLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRPFQHGQYYG
                     YLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTLP
                     LTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKPCLPRGLPPAP
                     LQVPAAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQGM
                     GIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR
                     LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGS
                     PSQSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDNLDVFGQTPSPRRMGEEPL
                     RPEPPTTLPTSGILPPAPGNAAVPERLEALRYQRIKKPKKSSKGSSKSKKRSDGSASQ
                     DQQLPNSQVLWPDEAVCLRKKKRHSRPDPFARLSDLCHRQLPEDQTAILNSVDHDDPG
                     HATLL"
     sig_peptide     229..279
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    349..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:409353"
     misc_feature    349..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:409353"
     misc_feature    349..363
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    349..363
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    403..417
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    403..417
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    514..528
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    514..528
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    556..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    556..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    643..903
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    643..903
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    697..711
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    697..711
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    736..750
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    736..750
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    841..858
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    841..858
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    880..891
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    880..891
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    910..1149
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    910..1149
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    949..951
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    1000..1002
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    1234..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1234..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1252..1266
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1252..1266
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1291..1308
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1291..1308
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1366..1380
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1366..1380
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1408..1425
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1408..1425
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1447..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1447..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1513..1743
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1513..1743
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1540..1554
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1540..1554
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1579..1593
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1579..1593
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1639..1653
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1639..1653
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1681..1698
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1681..1698
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    <1696..>2433
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    <1696..>2433
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1720..1731
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1720..1731
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1756..2043
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1756..2043
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1756..1758,1960..1962,2005..2007)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1756..1758,1960..1962,2005..2007)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2008..2013,2017..2022)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2008..2013,2017..2022)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2110..2112
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    2407..2469
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     transmembrane region"
     misc_feature    2512..2691
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2563..2565
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    2587..2589
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    2620..2622
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    <2920..3966
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2920..3966
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2980..3360
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3559..4224
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3646..3648
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:E9PZ19; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); methylation site"
     misc_feature    3859..3861
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    3883..3885
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:E9PZ19; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     exon            293..490
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            491..637
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            638..789
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            790..907
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1049
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1195
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1338
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1479
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1596
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1747
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1871
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2047
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2274
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2359
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2521
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2567
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..4223
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4345
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..5011
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctctgcc tccgttggca gtgcaggtgc cgctgcgccg gggcccggga ggctgcgcgc
       61 gccgagacga gaggagccag ggagggatgg agagcgggcc gcccgggcta cagaagcacc
      121 ggcaaggggc gtaggcgggc gagaagcggg cattgaggca ccagaagtgt gcagacgcag
      181 gagcactttg cgataggatg aggctcttgg ctggcgcgcg gtagtactat gatttggtat
      241 gtggccactt tgatagcaag tgtgatcagc acccgaggtc ttgtggctca agttgcccac
      301 ggcctgcgag aggaacctga gtttgtgacc gctcgtgccg gcgaaggtgt ggttctgcga
      361 tgcgacgtca tccacccagt gacaggacag cccccaccct atgtcgtaga gtggttcaag
      421 tttggggtcc ccatccctat cttcatcaag tttggctact atcccccgca tgtggaccct
      481 gagtatgcag gccgggccag tcttcatgat aaagcatctc tgcggctgga gcaggtgcgc
      541 tctgaggacc agggttggta cgagtgcaaa gtgctcatgc tggatcagca gtatgacaca
      601 ttccacaacg gcagctgggt ccatctcacc attaacgccc ctcccacctt tacagaaaca
      661 cccccccagt acatcgaggc caaggaaggt gggagtatta ccatgacttg cacggctttt
      721 gggaacccta aacccatcgt cacctggctc aaggaaggga ccctcctcag tgctagtgga
      781 aagtatcagg tgagtgacgg tagcctaacg gtgacgtcag tcagtcggga ggacagaggc
      841 gcctatacct gtcgagcata tagcatccag ggtgaggctg tgcacacaac ccatctgctt
      901 gttcaagggc ctcccttcat tgtttcccct cctgagaaca tcaccgtcaa catctcccag
      961 gatgctctgc ttacctgcag ggcagaggcg tatcccggca acctcaccta cacctggtac
     1021 tggcaggatg agaacgtcta cttccagaat gacctgaagc taagggtgcg gatcctgatt
     1081 gatgggacac tgatcatctt ccgagtgaag ccagaggatg ctgggaagta tacctgtgtc
     1141 cctagcaaca gcctggggcg ttccccctct gcctcagcat acctgactgt gcagtaccca
     1201 gcccgtgtcc tcaacatgcc ccctgtaatt tatgtgcccg tgggaatcca tggctatatc
     1261 cgctgtcctg tggatgcaga gccgcctgct actgtggtga agtggaataa ggatggccgg
     1321 cccctgcagg tagagaagaa cttgggttgg accttgatgg aggatggctc tattcgaatt
     1381 gaggaggcca cagaggaggc tcttggcact tacacctgtg tgccttacaa cactttgggg
     1441 accatgggcc agtctgcccc tgcccggctc gtcctgaagg accccccgta tttcacggtg
     1501 ctacccggct gggagtacag gcaggaggct ggccgggagc tgctcatccc ctgtgcagct
     1561 gcaggggacc ccttccctgt catcacctgg aggaaggtag ggaagcccag cagaagcaag
     1621 cacaatgcac tgcccagcgg gagtctgcag tttcgtgccc tgagtaagga ggaccacggg
     1681 gagtgggaat gtgttgccac caacgtggtc acaagcatca ctgccagcac ccacctcact
     1741 gtcatcggca ccagtcccca tgccccaggc agtgtccggg tccatgtctc catgacaact
     1801 gccaacgtgt cctgggagcc aggctatgat ggaggctatg agcagacatt ctcagtttgg
     1861 tacggacctc tgatgaagcg ggctcagttt gggccccacg actggctgtc cttgtcagtg
     1921 ccactgggcc ccagctggct gctggtagac agcctggagc ctgagactgc ataccagttc
     1981 agtgtcctgg cccagaacag gctggggacc agcgccttca gtgaggtggt cactgtgaac
     2041 actttagcat tccctgttac aactccagaa cccctggtgc tggtgacccc accaaggtgc
     2101 ctcacagcca accggaccca gcagggtgtg ctcctgtcct ggctccctcc tgccaaccac
     2161 agcttcccca tcgaccgcta catcatggag ttccgagttg gggagcgctg ggagatgcta
     2221 gatgatgcca taccaggcac cgatggagaa ttttttgcca aggatctgtc acaggatacc
     2281 tggtatgagt tccgggtttt ggctgtcatg caggatctga tcagcgagcc cagcaacatc
     2341 gccggtgtct ccagcacaga catcttcccg cagccggacc tgactgatga tgggctggcc
     2401 cggccagtgt tggctgggat agtggccacc atctgcttcc tggcggctgc catcctcttc
     2461 agcactctgg ctgcctgctt tgtcaacaag cagcgcaaac gcaaactcaa gcggaagaaa
     2521 gatcctccgc tctccatcac tcactgtagg aagagtcttg agtctccctt gtcctctggc
     2581 aaggtgagtc ctgagagtat ccgcacactc cgagccccgt ctgaatcctc tgacgaccag
     2641 ggccagccag cagccaagag gatgctgagc cctacaaggg agaaagagct gtccctgtac
     2701 aaaaaaacca agagggctat cagcagcagg aagtatagcg tggccaaggc tgaggccgaa
     2761 gcagaggcca ccacacccat tgaactgatc agtagaggcc cggatggccg cttcgtcatg
     2821 ggcccgtcgg agatggagcc ctctgtgaag ggccggcgaa tcgaaggctt ccccttcgct
     2881 gaggagacgg acatgtaccc tgagttccgg cagtcagatg aggagaatga agacccactg
     2941 gtacccacgt ctgtggctgc tctgaagcct caactgaccc ctatgtcttc cagccaggac
     3001 tcttacctgc caccaccagc atacagccct cggttccagc ctcgagggct cgagggcccc
     3061 agtggactgg gaggacgact ccaggctact ggccaagcga ggcctcctgc ccctcggccc
     3121 ttccagcatg gccagtatta tgggtacctc agcagcagca gccctgggga ggtggagcct
     3181 ccacccttct atatgccaga agtgggcagc cccttgagct cagtcatgtc gtccccaccc
     3241 ctgcacaccg aggggccttt tggccaccct accatccctg aggaaaacgg agagaatgct
     3301 tctaacagca ctttgccctt gactcagaca cctacaggag ggcgctcccc tgagccctgg
     3361 ggccggccag aatttccctt tgggggactg gagaccccag ctatgatgtt cccccaccag
     3421 ctgcacccct gtgatgtggc cgagagtttg cagcccaagc cctgtctgcc ccgaggactg
     3481 cccccagccc cgctccaggt gcctgcagcc tatccaggca tgctatctct ggaggcacca
     3541 aagggctggg taggcaagtc acctggcagg ggtcccatcc cggcgccccc tgccaccaag
     3601 tggcaggaaa gacctatgca acctctggtc agccaagggc agctaagaca taccagccaa
     3661 ggtatgggga taccggtgtt gccttacccg gagccagccg agcccggggg gcacggtggc
     3721 cccagcacat ttggcctgga cactcggtgg tatgagcccc agccccggcc ccggcccagc
     3781 ccccggcagg cccggcgtgc cgagcccagt ttacatcaag tggtgctaca gccctcccgg
     3841 ctctcacctc tgacccaaag cccccttagt tcccgcactg gctcccctga gctcgctgct
     3901 cgtgcccgac ctcgaccagg cctcctgcag caggcagaga tgtcagagat caccctgcag
     3961 ccgccagccg cggtcagctt ctctcgcaag tcaacaccat catccacggg atctccttca
     4021 cagagcagcc gcagtgggag ccccagctac aggcccacaa tgggcttcac tactctggcc
     4081 acaggctacc cttctccacc acctggccct gcccctccgg cgccagggga caacttggat
     4141 gtgtttggac agacgccttc ccctcggagg atgggggagg agccactccg gccagagccc
     4201 ccaacaacct tacctacttc aggaatactt ccacctgcac ccgggaacgc tgctgtgcct
     4261 gagaggctgg aggctctgag ataccaacgg ataaagaagc ccaaaaagtc atccaagggc
     4321 tcttcgaagt caaagaaacg atccgacggt tctgcctccc aggatcagca gcttcccaac
     4381 tctcaggttc tgtggcccga cgaagctgtc tgcctcagaa agaagaagag acactctcgt
     4441 cctgatccct ttgcccggct ttcagacttg tgccaccgtc agcttccaga agaccagacg
     4501 gccatcctca acagtgtgga tcatgatgac ccaggccacg ctactctgct atgacttgac
     4561 accattctaa atgtccccag ggtggggtgc taggctaaag ggggcagaga gggaccattg
     4621 tacagggcct tgtcctcctc tgcccatcat gggatggctc aggcccctga cctgtgtgta
     4681 ttccctcatg ccagtgggga atacacccac tatctagcca gctagccttg cccatgggac
     4741 agaggactag gggaagagct tttaactgtg ggtcagagtt gggagtatgt ggggatagaa
     4801 gacatctgtc tctatgccac ctctcccact ttactagatt ggttcttctc acctcttcca
     4861 acgtcttagg aagtgaggaa acggaaagca atggctttta gtaatgcatt tgtttcactt
     4921 ttccaagtcc tgggaggggg ttagagttat atccgaccct cctaactcca catatatata
     4981 gatatagata caaatgcact tgtgtgtcgt t
//
LOCUS       NM_001436473            4172 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 4,
            mRNA.
ACCESSION   NM_001436473 XM_039081142
VERSION     NM_001436473.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081142.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212313.1, SRR26643287.20622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  84597170-84597330
            162-346             JAXUCZ010000008.1  84629460-84629644
            347-549             JAXUCZ010000008.1  84630342-84630544
            550-675             JAXUCZ010000008.1  84630809-84630934
            676-2488            JAXUCZ010000008.1  84632504-84634316
            2489-2602           JAXUCZ010000008.1  84636539-84636652
            2603-2682           JAXUCZ010000008.1  84638961-84639040
            2683-2791           JAXUCZ010000008.1  84640128-84640236
            2792-2950           JAXUCZ010000008.1  84641283-84641441
            2951-3019           JAXUCZ010000008.1  84645727-84645795
            3020-3216           JAXUCZ010000008.1  84647790-84647986
            3217-4172           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4172
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..161
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             125..3370
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 4 is encoded by transcript variant 4;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 4"
                     /protein_id="NP_001423402.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MVFSGNKGLRRQDALDEYFEYDAEEFLVSLALLITEGRTPECSV
                     KGRAESFHCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLL
                     PDCCYSDEGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSF
                     VFFSQLSAWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKV
                     SVQSLPRQAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCS
                     KHTWTMAPVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVR
                     SQEASVRTFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCD
                     PSSSRMSELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEG
                     KVKEKLETRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAH
                     IPRPAFSKHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPK
                     PSKCFRSFKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNE
                     SSLALIGRLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGS
                     LSHLQCDESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLS
                     EDTEGSKSTISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLRTTLKHSSVW
                     RKHDFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRP
                     CLNIEADPGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASG
                     TFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNK
                     TVVKMFVVVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHL
                     RFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    2774..2947
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    2774..2947
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3191..3364
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3191..3364
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            162..346
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            347..549
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            550..675
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            676..2488
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2602
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2682
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2791
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2950
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3019
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3216
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..4172
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttgtga gaagcctgca cgggaagcgg agcacccagc gcttgctccg cgctcgctca
       61 ctctgctccc gtgctttccc tctgcggctg acagtgtagc agctgacagc cagaggcttc
      121 cagtatggtt ttcagtggga acaaagggct ccgcagacaa gatgccttgg atgagtattt
      181 tgaatatgat gcagaggagt tcttggtctc tttggccttg ctgataactg aaggccgaac
      241 ccctgagtgt tccgtgaaag gccgtgcaga gagtttccac tgccctccag cgcagtctcg
      301 tttcccaggc gcagccagac atgagtgcag cgacaagctg gcccagtgtc gccaagccag
      361 acgaaccaga tctgaggtca cgctgttgtg gaaaaataat cttccaatca tggtagaagt
      421 gatgcttctg ccagattgct gctacagtga cgagggccct agcacagagg ggacagatct
      481 gaatgaccct gccattaaac aagatgcact gttactggag aggtggatct tggagccagt
      541 tccccgacag aatggcgatc gcttcatcga agagaaggca cttctgctgg ctgtcagatc
      601 attcgtgttt ttttctcagt taagtgcttg gctgagtgtt tctcatggtg ctattccacg
      661 aaacattctt tacagaatca gtgctgctga tgtcgacctg cagtggagtt tttcacagac
      721 tccaactgag catgtgtttc ccgttcccaa tgtctctcac aacgtggcct tgaaagtcag
      781 cgttcagtcc ttacccagac aagctcatta tccagttttg acctgtagta tccatactaa
      841 tattggtctg tatgagaaga gaattcagga acaggagctt cgagcctgtc agcaccgtgg
      901 ccctggtgaa gtggagtacc gttgtcccag cagctctcag agtctgtgca gcaagcacac
      961 atggaccatg gcacctgtga gtgccctgca tgtcagaagt ggcatgcctc ctgagtacac
     1021 tgcagccatt agaaatgtca ggctctgccc aggcacaggt agcaagtctg acaatggaac
     1081 acctcaagcc agcgtcctgg gcttcagtgg cactggagaa gtgaggtccc aggaggcatc
     1141 agtgagaact ttcaaatcac tctctgtgat cgattccagt gtctccagct gtcagagctc
     1201 ccggcagcca gtaggggagc ctaacccttt aatcgactcc ctgattcagg atcgacaaga
     1261 agtcattgcc aggattgctc agcacttgat tcactgtgac cccagctcct ctcgcatgtc
     1321 tgaactcccc tttaacaccc cagagtccac ttcacttagc ccaaagcttc acccagtttc
     1381 acaggagagt gggtattcga gaagatgcaa agaagcattc tctgtctctt ttgggagtcc
     1441 agagtttggc tccccaggag acagcaagga ggggaaagtg aaagagaagc tggaaaccag
     1501 gcaaggagaa acctgtgcct ctcacagtcc ctaccctcgg cagcctgctg gggaggcaaa
     1561 cccactgatt ggctctttgc ttctggagcg gcaggatgtc atagccagga tcgcacagca
     1621 cttggagcac atcgacccca cagctcacat tccccggcct gcgttcagca agcacgactc
     1681 caattccatt ccttctaaag tgttcaggag ttcatttcat gacaaaacca tgttgaagaa
     1741 ggacagagag aatgtctctg tttctgctac tcatacagaa gtgtccttat tgggagacag
     1801 aggtgatggg aaaagcccca aacctagtaa atgtttccga tctttcaaaa acagtcctca
     1861 agaaaagtct ctgaaacctg aagaaagcgc tcagcatcag aaccatcctg atgacatcac
     1921 ccacacagcc aggcaggagt tgctgaacaa ggctgctggc ttactcactt cctctaactc
     1981 gtccctctgc aatgaaagca gcttggcttt gattggcaga ttggaaagta catcttgtaa
     2041 attacaactt aggaagcaag aaatgagcca tgaaactgag aaacagtgtt tgcattgcaa
     2101 cagtattgac aaacagattt gcacaaataa atgcacagag aaaataaaag atgagaatag
     2161 cccgggctct ctcagtcatc tccagtgtga tgagtcaaga ggtattgacc caaaaataaa
     2221 agtgactatg ttggaaatgc ctgactattt gaacaagtac aaaactaatt gttcaaataa
     2281 agactccaaa agatcaaaga catgtgagca aaacattcag cttggcacag aaaattatct
     2341 cagtgaagat actgagggtt ccaaaagcac aatatcagac caactaaaaa ctgagcagga
     2401 ggaaaacaaa gattcagttg ccggaaaacc tccaagtgta aagcactgtc tgtctacaag
     2461 cgaaagactg aaaaatgcag acatgttgag gactacactg aagcattcaa gtgtctggag
     2521 gaaacacgat tttcattccc tggatgggac atcaaccaga gcctttcatc ctcagacagg
     2581 gctgcctctc ctctcaagcc cagttcctca aagaaaaaca cagtcaggtt gctttgatct
     2641 agacacgtca ctactgcatc tgagaagtct atcctccaaa agctctcgac cgtgtctgaa
     2701 cattgaagcg gacccaggtg ttcatgaaaa gccttttttg agttcaagtg ctccaccaat
     2761 cacaagtctt agtctcctag ggaattttga ggaatcggtt ctgaattacc gtttagaccc
     2821 cctcggcata gttgatggct tcactgctga ggtgggagcc agtgggactt tctgccctac
     2881 gcacttgact ctgccggtgg aagtgtcgtt ctacagtgtt tcggatgata acgctccctc
     2941 gccttatatg ggtgtgatta ctttagagtc ccttggtaaa aggggttatc gagtacctcc
     3001 ttcaggaacg atacaagtga ccttattcaa tcccaataag actgtggtga agatgtttgt
     3061 tgtcgtgtat gacctacgaa gtatgccagc caatcaccag acattcctgc ggcagaggac
     3121 gttttctgtt cctgttaaac aagaaatgaa gagaagtatt aacaaagaga atgtccagca
     3181 cacggcacag ttactacgct acctcataca cctgaggttc cagagctcta aatctgggaa
     3241 gatctacctc catagagatg tccggctcct gttctctaga aagtccatgg aggttgatag
     3301 cggtgctgct tatgaactca agtcttacac cgaatcgcca acaaacccac agttttcacc
     3361 aagatgctga taagggagac ggattaaaag tatttgctca gtacccaagc ttgaacgtga
     3421 gcattcaccg agtggaatac atccaatgag agccagtgga gtggagtggc cctcctcttg
     3481 tcctggacca gattttatta aaggacccct gaactgagac ccatgactcc taagtggact
     3541 ggaagcaccc ctgtcttcac ccttttcgta ctgttgaaac cacttcattg gacagttgca
     3601 atagcaaaat ccccagttag attagtgttt acacatttta tttctgttat ttaatattta
     3661 atgttttcct taatagtcaa gtgatgtttg tctctagtgt tctaatgtag cacaatctat
     3721 gtaaaatcat actatgtatt tttgacatta atgttgaaat tgaaatatat gcataagtct
     3781 ttaattttgt gtggtgtgtt ttaagtgcta ttcatttaag ctactgaaaa tgagaatgaa
     3841 atgttgggct tctttaagat taatgcacta tgcaagcatg tatgcttttg atatctctcc
     3901 aggttaggtt ttaaagaact caccagggct gttcccaggg gtccgacaaa gctgctccca
     3961 tcctcctggc aaacactcag cctcctgccc attctcatcc ttctaagatc ccccccaccc
     4021 caaaaacatt ctattttccc tgaatcacta ctgtagaggt tttactttaa attgctatcc
     4081 catgctacat aattttctca cactgttaaa aagaatatgt actttgaaaa gaatttaata
     4141 tttatattgt aaatatatgc aaaaaactaa aa
//
LOCUS       NM_001436508            4273 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 5, mRNA.
ACCESSION   NM_001436508 XM_006243009
VERSION     NM_001436508.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4273)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4273)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4273)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4273)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4273)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4273)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243009.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1017            JAXUCZ010000008.1  58249615-58249694
            1018-1166           JAXUCZ010000008.1  58254695-58254843
            1167-1294           JAXUCZ010000008.1  58256533-58256660
            1295-1390           JAXUCZ010000008.1  58258205-58258300
            1391-1614           JAXUCZ010000008.1  58266333-58266556
            1615-1685           JAXUCZ010000008.1  58267575-58267645
            1686-1914           JAXUCZ010000008.1  58268925-58269153
            1915-2106           JAXUCZ010000008.1  58271693-58271884
            2107-2246           JAXUCZ010000008.1  58273167-58273306
            2247-2426           JAXUCZ010000008.1  58273482-58273661
            2427-2522           JAXUCZ010000008.1  58274560-58274655
            2523-2701           JAXUCZ010000008.1  58276058-58276236
            2702-2780           JAXUCZ010000008.1  58276347-58276425
            2781-2860           JAXUCZ010000008.1  58277395-58277474
            2861-2984           JAXUCZ010000008.1  58277966-58278089
            2985-3180           JAXUCZ010000008.1  58279354-58279549
            3181-4273           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4273
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3356
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 5 is encoded by transcript variant 5;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     5"
                     /protein_id="NP_001423437.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQV
                     IYMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLESSSPKSCSQNAEGSFSSPEDAL
                     PNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNC
                     ISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYNDIS
                     VTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVELR
                     QYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCLSS
                     EHAVIAKEQTAQAIANTAHAYEKSGVEAALSEHKEAEPEKPQETNLAEQSEQAAEVKD
                     TEAAAPPNSEVSEVEIPSVGRILVRSDADGYDEEVMLSPAMQGVLLAIAKARQTFDRD
                     GSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQF
                     ADRNLSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGLEL
                     FQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFET
                     NDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQL
                     CLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    591..1886
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..1886
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1740..1742,1794..1796)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1740..1742,1794..1796)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    2514..3353
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2514..3353
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1166
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1390
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1614
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1685
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1914
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2106
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2246
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2426
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2522
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2701
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2780
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2860
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2984
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3180
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..4273
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacag caatcccagg actaaatctg
      961 aaaaccccat ggtgcagctg ttctacggta ccttcctgac agaaggggtc cgagaaggaa
     1021 aacccttttg taacaacgag accttcggcc agtaccctct tcaggtaaac ggttaccaca
     1081 acttagacga gtgtttggaa ggggccatgg tggaaggtga cattgcgctg cttccttctg
     1141 atcgctcagt gaaatacgga caagagcgtt ggtttacaaa gctgcctcca gtgttgacct
     1201 tcgaactctc cagatttgag tttaatcagt ctcttgggca gcctgagaaa attcataata
     1261 agctggaatt tcctcaggtt atttatatgg ataggtacat gtacaaaagc aaagagctta
     1321 tccgaagtaa gagagagagc attcgaaagt tgaaggagga aatacaagtt ctgcagcaga
     1381 aattagaaag ttcaagtccc aaaagctgct ctcagaatgc tgagggttcc ttttcctctc
     1441 cggaagatgc tctacccaac tctgaggtaa tgaatgggcc atttacttct cctcactctt
     1501 ccctggaaat gcctgcaccc ccaccagctc ctcggacagt cacagatgag gaaatgaatt
     1561 tcgttaagac ctgtcttcag aggtggcgga gtgaaattga acaggatata caagacttaa
     1621 agaattgtat ctcgagcacc acccaggcta ttgagcagat gtactgtgat cctcttcttc
     1681 gtcaggtgcc ttatcgctta catgcagttc ttgttcatga aggacaagcc agtgcagggc
     1741 actactgggc gtacatctat aaccagcccc ggcagatctg gctcaaatac aacgacatct
     1801 ctgtcactga gtcttcctgg gaagaacttg aaagagattc ttacgggggc ctgagaaatg
     1861 tcagcgcata ctgcttgatg tatatcaatg acaagttgcc ccactgcagt gcagaggcag
     1921 cgcatggtga atctgatcag actgcagaag tggaagccct gtctgtggaa ctcaggcagt
     1981 acattcagga agataactgg aggtttgagc aagaggtgga ggaatgggag gaagaacagt
     2041 cctgtaagat cccacagatg gagtcctccc caaactcttc ctcacaggat ttttccacat
     2101 cacaagagtc ttcagcagcg tcctcgcatg gcgttcgatg tttgtcttct gaacatgctg
     2161 tgattgcaaa ggagcagact gcccaggcca tcgcaaacac ggctcatgcc tatgagaaga
     2221 gcggggtaga agcagccttg agtgagcata aggaagctga acccgagaag ccccaggaaa
     2281 caaaccttgc agagcagtca gaacaggctg cagaggtcaa agacacagag gctgctgccc
     2341 cacctaactc tgaggtctct gaagtggaga tccccagtgt gggaaggatt ctggttagat
     2401 ctgatgcaga tggctatgat gaggaggtga tgctgagccc tgccatgcaa ggggtcctcc
     2461 tggccatagc taaggcgcgc cagacctttg accgagacgg gtctgaagca gggcttatta
     2521 aggcatttca tgaagagtac tccaggctct atcagcttgc caaagagaca cccacctctc
     2581 acagtgatcc tcgccttcag catgttctcg tctacttttt ccaaaatgaa gcacccaaga
     2641 gggtagtaga acgaaccctt ctggaacagt ttgcagatag aaaccttagc tatgatgaga
     2701 gatctatcag tatcatgaag gtggctcagg ccaaactgat ggaaattggt ccagaggaca
     2761 tgaacatgga agagtataag aggtggcatg aagactatag tctgttccga aaggtgtctg
     2821 tgtacctgct aacgggcctg gaactcttcc aaaaaggaaa gtaccaggaa gctttgtcct
     2881 acctggtgta cgcgtaccag agcaatgctg gcctgctggt gaaggggccc cgcaggggcg
     2941 tgaaggagtc tgtgattgct ttgtaccgca gaaaatgcct tctggagttg aatgccaagg
     3001 ctgcttctct ttttgaaaca aatgacgacc attctgtaac agagggcatt aatgtgatga
     3061 atgagctgat cattccctgc atccacctga tcattaataa tgacatttcc aaggacgacc
     3121 ttgatgccat cgaggtcatg aggaaccact ggtgctctta cctggggaag gacatcgcag
     3181 aaaatctgca gctgtgttta ggggagttcc tacccaggct tctagatcct tccgcagaaa
     3241 tcatcgtcct aaaggagcct ccaactattc gaccgaattc tccctatgat ctttgcagcc
     3301 ggtttgcagc tgtcatggag tccattcaag gagtttcaac agtaacagtg aagtaaactg
     3361 cacatggacg gtcaagactc attttggtct ccagtcacct gccagttaca cggcagtctg
     3421 ttgttgcaga ctcccctgga gagagagatt gggtgtctga gcaagattta gaccctctgc
     3481 cctctctgat atgtgtttaa gggattaagg ataaagttgc gcatttaggt acagaatcat
     3541 gagagctctc tcactgaaga aggcaggagc ccggtgcatt aaggttttga attatcccag
     3601 aagacctgaa ttgccttttt aaatctccca taataattac ccttcgggcg cctgtctcat
     3661 cagaactgag ccggaggaac agtttctggt tcttttgtca agttcaggtg acgtttctaa
     3721 gtccttagct accagagatt ggcaacaggg gccttgcctg gctcttgaca gtaacacaaa
     3781 gggtgctgct gagcctttcc ctccacacaa gggtagagcg taaggcttcg cccaccatga
     3841 agccacagga aagctgcctc cattttcggt ctgtttatat ttcagataaa ccagaaaacc
     3901 tcacactcag tcttgagtga aagagaagca agcatcctgg gctctcaccc cagtgctggt
     3961 gtaaagctgc acaagggaca tttaatagct aattaagcaa cattgtggag attgtcacat
     4021 gcaggtgtct aaggctacct ggcctgatag aattttgatt ctctctttcc tttttttttt
     4081 tttagaaata agggatgtga atttatatag agagagacca tctatctgtg tatatgtaga
     4141 gaagctgctt tttaaagaac ttttaattgg gaattcatgt tttaacaaaa ttttaaggat
     4201 taacgaggaa tcatgggagg gaagaacaca actatgcaga ttttataaat gtgcaataaa
     4261 agtatttgtt tta
//
LOCUS       NM_001436506            4273 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 3, mRNA.
ACCESSION   NM_001436506 XM_006243008
VERSION     NM_001436506.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4273)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4273)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4273)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4273)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4273)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4273)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243008.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.44077.1,
                                           SRR26643290.29169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1017            JAXUCZ010000008.1  58249615-58249694
            1018-1166           JAXUCZ010000008.1  58254695-58254843
            1167-1294           JAXUCZ010000008.1  58256533-58256660
            1295-1390           JAXUCZ010000008.1  58258205-58258300
            1391-1570           JAXUCZ010000008.1  58264169-58264348
            1571-1794           JAXUCZ010000008.1  58266333-58266556
            1795-1865           JAXUCZ010000008.1  58267575-58267645
            1866-2094           JAXUCZ010000008.1  58268925-58269153
            2095-2286           JAXUCZ010000008.1  58271693-58271884
            2287-2426           JAXUCZ010000008.1  58273167-58273306
            2427-2522           JAXUCZ010000008.1  58274560-58274655
            2523-2701           JAXUCZ010000008.1  58276058-58276236
            2702-2780           JAXUCZ010000008.1  58276347-58276425
            2781-2860           JAXUCZ010000008.1  58277395-58277474
            2861-2984           JAXUCZ010000008.1  58277966-58278089
            2985-3180           JAXUCZ010000008.1  58279354-58279549
            3181-4273           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4273
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3356
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     3"
                     /protein_id="NP_001423435.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQV
                     IYMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVI
                     EFASTKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPED
                     ALPNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLK
                     NCISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYND
                     ISVTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVE
                     LRQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCL
                     SSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEVMLSPAMQGVLLAIAKARQTFDRD
                     GSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQF
                     ADRNLSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGLEL
                     FQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFET
                     NDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQL
                     CLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    282..350
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    303..305
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    1230..1232
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    1551..1721
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1770..1772
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5I043; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    2211..2288
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2262..2264
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    2514..3353
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2514..3353
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    3264..3266
                     /gene="Usp28"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1166
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1390
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1570
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1794
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1865
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2094
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2286
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2426
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2522
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2701
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2780
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2860
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2984
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3180
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..4273
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacag caatcccagg actaaatctg
      961 aaaaccccat ggtgcagctg ttctacggta ccttcctgac agaaggggtc cgagaaggaa
     1021 aacccttttg taacaacgag accttcggcc agtaccctct tcaggtaaac ggttaccaca
     1081 acttagacga gtgtttggaa ggggccatgg tggaaggtga cattgcgctg cttccttctg
     1141 atcgctcagt gaaatacgga caagagcgtt ggtttacaaa gctgcctcca gtgttgacct
     1201 tcgaactctc cagatttgag tttaatcagt ctcttgggca gcctgagaaa attcataata
     1261 agctggaatt tcctcaggtt atttatatgg ataggtacat gtacaaaagc aaagagctta
     1321 tccgaagtaa gagagagagc attcgaaagt tgaaggagga aatacaagtt ctgcagcaga
     1381 aattagaaag gtatgtgaag tacggctccg gtccatctcg cttcccactc cccgacatgt
     1441 tgaaatacgt tattgaattt gccagtacaa aacctgcctc tgaaagctgt ctgtctggaa
     1501 gtgttgagca tatgacgtta ccacttcctt ctgtgcactg cccgatttct gacctcacag
     1561 ccaaggaaag ttcaagtccc aaaagctgct ctcagaatgc tgagggttcc ttttcctctc
     1621 cggaagatgc tctacccaac tctgaggtaa tgaatgggcc atttacttct cctcactctt
     1681 ccctggaaat gcctgcaccc ccaccagctc ctcggacagt cacagatgag gaaatgaatt
     1741 tcgttaagac ctgtcttcag aggtggcgga gtgaaattga acaggatata caagacttaa
     1801 agaattgtat ctcgagcacc acccaggcta ttgagcagat gtactgtgat cctcttcttc
     1861 gtcaggtgcc ttatcgctta catgcagttc ttgttcatga aggacaagcc agtgcagggc
     1921 actactgggc gtacatctat aaccagcccc ggcagatctg gctcaaatac aacgacatct
     1981 ctgtcactga gtcttcctgg gaagaacttg aaagagattc ttacgggggc ctgagaaatg
     2041 tcagcgcata ctgcttgatg tatatcaatg acaagttgcc ccactgcagt gcagaggcag
     2101 cgcatggtga atctgatcag actgcagaag tggaagccct gtctgtggaa ctcaggcagt
     2161 acattcagga agataactgg aggtttgagc aagaggtgga ggaatgggag gaagaacagt
     2221 cctgtaagat cccacagatg gagtcctccc caaactcttc ctcacaggat ttttccacat
     2281 cacaagagtc ttcagcagcg tcctcgcatg gcgttcgatg tttgtcttct gaacatgctg
     2341 tgattgcaaa ggagcagact gcccaggcca tcgcaaacac ggctcatgcc tatgagaaga
     2401 gcggggtaga agcagccttg agtgaggtga tgctgagccc tgccatgcaa ggggtcctcc
     2461 tggccatagc taaggcgcgc cagacctttg accgagacgg gtctgaagca gggcttatta
     2521 aggcatttca tgaagagtac tccaggctct atcagcttgc caaagagaca cccacctctc
     2581 acagtgatcc tcgccttcag catgttctcg tctacttttt ccaaaatgaa gcacccaaga
     2641 gggtagtaga acgaaccctt ctggaacagt ttgcagatag aaaccttagc tatgatgaga
     2701 gatctatcag tatcatgaag gtggctcagg ccaaactgat ggaaattggt ccagaggaca
     2761 tgaacatgga agagtataag aggtggcatg aagactatag tctgttccga aaggtgtctg
     2821 tgtacctgct aacgggcctg gaactcttcc aaaaaggaaa gtaccaggaa gctttgtcct
     2881 acctggtgta cgcgtaccag agcaatgctg gcctgctggt gaaggggccc cgcaggggcg
     2941 tgaaggagtc tgtgattgct ttgtaccgca gaaaatgcct tctggagttg aatgccaagg
     3001 ctgcttctct ttttgaaaca aatgacgacc attctgtaac agagggcatt aatgtgatga
     3061 atgagctgat cattccctgc atccacctga tcattaataa tgacatttcc aaggacgacc
     3121 ttgatgccat cgaggtcatg aggaaccact ggtgctctta cctggggaag gacatcgcag
     3181 aaaatctgca gctgtgttta ggggagttcc tacccaggct tctagatcct tccgcagaaa
     3241 tcatcgtcct aaaggagcct ccaactattc gaccgaattc tccctatgat ctttgcagcc
     3301 ggtttgcagc tgtcatggag tccattcaag gagtttcaac agtaacagtg aagtaaactg
     3361 cacatggacg gtcaagactc attttggtct ccagtcacct gccagttaca cggcagtctg
     3421 ttgttgcaga ctcccctgga gagagagatt gggtgtctga gcaagattta gaccctctgc
     3481 cctctctgat atgtgtttaa gggattaagg ataaagttgc gcatttaggt acagaatcat
     3541 gagagctctc tcactgaaga aggcaggagc ccggtgcatt aaggttttga attatcccag
     3601 aagacctgaa ttgccttttt aaatctccca taataattac ccttcgggcg cctgtctcat
     3661 cagaactgag ccggaggaac agtttctggt tcttttgtca agttcaggtg acgtttctaa
     3721 gtccttagct accagagatt ggcaacaggg gccttgcctg gctcttgaca gtaacacaaa
     3781 gggtgctgct gagcctttcc ctccacacaa gggtagagcg taaggcttcg cccaccatga
     3841 agccacagga aagctgcctc cattttcggt ctgtttatat ttcagataaa ccagaaaacc
     3901 tcacactcag tcttgagtga aagagaagca agcatcctgg gctctcaccc cagtgctggt
     3961 gtaaagctgc acaagggaca tttaatagct aattaagcaa cattgtggag attgtcacat
     4021 gcaggtgtct aaggctacct ggcctgatag aattttgatt ctctctttcc tttttttttt
     4081 tttagaaata agggatgtga atttatatag agagagacca tctatctgtg tatatgtaga
     4141 gaagctgctt tttaaagaac ttttaattgg gaattcatgt tttaacaaaa ttttaaggat
     4201 taacgaggaa tcatgggagg gaagaacaca actatgcaga ttttataaat gtgcaataaa
     4261 agtatttgtt tta
//
LOCUS       NM_001436496            5470 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 6, mRNA.
ACCESSION   NM_001436496 XM_063265379
VERSION     NM_001436496.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5470)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5470)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5470)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265379.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2154299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000008.1  38090295-38090648
            355-527             JAXUCZ010000008.1  38092744-38092916
            528-729             JAXUCZ010000008.1  38095209-38095410
            730-857             JAXUCZ010000008.1  38098165-38098292
            858-1032            JAXUCZ010000008.1  38099310-38099484
            1033-1170           JAXUCZ010000008.1  38099986-38100123
            1171-1244           JAXUCZ010000008.1  38100738-38100811
            1245-1329           JAXUCZ010000008.1  38101595-38101679
            1330-1510           JAXUCZ010000008.1  38102404-38102584
            1511-1619           JAXUCZ010000008.1  38103121-38103229
            1620-1746           JAXUCZ010000008.1  38103788-38103914
            1747-1809           JAXUCZ010000008.1  38104180-38104242
            1810-1889           JAXUCZ010000008.1  38105285-38105364
            1890-1936           JAXUCZ010000008.1  38105453-38105499
            1937-1997           JAXUCZ010000008.1  38106233-38106293
            1998-2172           JAXUCZ010000008.1  38106533-38106707
            2173-2279           JAXUCZ010000008.1  38108447-38108553
            2280-2403           JAXUCZ010000008.1  38110471-38110594
            2404-2483           JAXUCZ010000008.1  38111060-38111139
            2484-2698           JAXUCZ010000008.1  38111280-38111494
            2699-2969           JAXUCZ010000008.1  38111574-38111844
            2970-3182           JAXUCZ010000008.1  38112380-38112592
            3183-3950           JAXUCZ010000008.1  38114925-38115692
            3951-4057           JAXUCZ010000008.1  38118990-38119096
            4058-4193           JAXUCZ010000008.1  38119994-38120129
            4194-5470           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5470
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..354
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            355..527
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             393..4319
                     /gene="Nfrkb"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 2"
                     /protein_id="NP_001423425.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEATLDL
                     QEKFSFEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKH
                     HEKRKHQPDHPDLLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKK
                     IKLIKSEAEDLAEPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFF
                     SLLLEILLLESQASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGES
                     RVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDA
                     MTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFD
                     KETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPD
                     VTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAK
                     ARKALQQKPKPPSKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPAL
                     PTPISPPPVSAVSRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQT
                     TARVVSHSSSAGLPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKV
                     VPQAVVATVPVKGQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSAS
                     TTAVIQNVTGQNIIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTD
                     AKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAAD
                     SPAKAPSASVPSSAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVAS
                     SEAKPAATIRIVQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINAT
                     VSKTVAVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPM
                     KGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQ
                     GQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1602..1859
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1602..1859
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2472..3086
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2472..3086
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3408..>3944
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    <3408..>3944
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            528..729
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            730..857
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1032
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1170
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1244
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1329
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1510
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1619
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1746
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1809
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1889
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1936
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..1997
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2172
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2279
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2403
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2483
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2698
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2969
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3182
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3950
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4057
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4193
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..5470
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggtgggg ctggagacgt ggggctacgg ccggagagcc ttgctcgcag cttgctcggg
       61 agggtctgga gggtgggcta gccccaggtg cagagaagag gccttcctgg tctagcgagg
      121 aagtcccgga caccccaaca cttagaaatc tgcagcttcc ggggtttcag ctcgctggta
      181 gcgccggtgt tttcgtattt tgagagagta agtggcaaga cagaggttgt cactagatat
      241 taacgtttag cttaaccaac cgtcggcact ggaagaagct tctgagcgag ttgtgtacat
      301 tatgcacctg tcagatgagg taactgactt tgcacgctgc ctatgccacg tacgggtgta
      361 tttttaggta gtgtacctgt ggagaagaaa caatggattc cttggatcac atgctgacag
      421 atcccctaga acttggtcct tgtggagatg gtcacagtac agggatcatg gaggactgcc
      481 ttctgggtgg aaccagggtt agtctgcctg aagacctgct ggaggatcct gaaatattct
      541 ttgacgtcgt cagcctctcc acatggcagg aagtactaag tgactctcag cgtgaacatc
      601 tccagcagtt tctgccgcag tttcctacag acactgtaga gcagcagaat gagctcatcc
      661 ttgccctatt cagtggggag aacttccgct tcggaaaccc tctgcacatc gcccagaagc
      721 tcttccgaga tggacacttt aaccctgagg tggtcaagta tcggcagctc tgcttcaagt
      781 cacagtacaa gcggtacctc agctcccaac agcagtattt ccaccggctg ctgagacaga
      841 ttcttgcttc cagaagtgat ctcctggaga tggctcgcac gagcggcccg gctcttccct
      901 ttcgacacaa gcaccattca ccatcccgaa gcccggagga gcgggagtgg cggacccagc
      961 agcgttacct gaaagtcttg agggaagtga aggaggagtg tggcgacact gccctgtcgt
     1021 ctgatgagga ggccacgttg gatttacaag aaaaattttc ttttgaagat ctcagctcat
     1081 ggcttccaag ctctccagca cgctctccta gtcctgcggt gcccctgagg gtggtgccca
     1141 cgctttccac cacggatatg aaaactgcag ataaaataga actgggggac agtgacctga
     1201 agttaatgtt aaagaaacac catgagaagc ggaaacatca accagatcac ccagaccttt
     1261 tgacagggga tctgactctc agcgacatca tgactcgagt aaatgccggc aggaagggct
     1321 ctctagcagc cttgtatgat ttggctgttc ttaaaaaaaa ggtgaaggaa aaggaggaga
     1381 agaaaaagaa gaaaataaag ttgattaaat cggaggcaga ggatctggct gagcccctaa
     1441 gcaatactga aggggtccca acgctctccc aggccccctc tcccctggca atatcgtcta
     1501 tcaaggaaga acccctggaa gacatcaagc cttgtcttgg aatcaatgaa atatcttcca
     1561 gttttttctc tcttctgtta gagatcttgc tgctggagag tcaggctagc cttcctatgc
     1621 tggaggaccg ggttttggat tggcagtctt ctccagccag ctccctcaac agctggttct
     1681 ctgctgcccc caactgggct gagttggtgt tgcctgctct gcagtatctt gctggagaaa
     1741 gccgagttcc ttccagtttt tctccatttg ttgaattcaa agagaaaacc cagcagtgga
     1801 aattgcttgg tcaatctcaa gataatgaaa aggaattagc cgctctcttc cacttgtggc
     1861 tagaaaccaa agaccaggct ttctgtaagc aggaaaatga agacagctca gatgccatga
     1921 cacctgtgcc tcgagtaaga actgactatg tggttcggcc tagcacagga gaggagaaac
     1981 gggtttttca agagcaggag cgttacaggt atagccaacc ccataaggca ttcacctttc
     2041 gcatgcatgg ctttgagtct gtggtggggc cagtgaaggg cgtgtttgac aaggagacct
     2101 ccctcaacaa ggctcgtgag cactcactgc tgcgctctga ccggcctgcc tatgtcacca
     2161 ttctgtctct tgttcgggat gctgcggctc ggctgcctaa tggagaaggc actcgggcag
     2221 agatctgtga gctgctcaag gactctcagt ttcttgctcc tgatgtcacc agcactcagg
     2281 tgaacacggt agtgagtggc gcactggatc gattgcatta tgagaaggac ccttgtgtga
     2341 aatacgacat tggtcggaag ctgtggatct acctgcatcg tgaccggagt gaggaagagt
     2401 ttgaacggat ccatcaagct caagcagcag cagctaaagc cagaaaagct cttcagcaaa
     2461 aacccaaacc gccatccaag gtgaagtcca gtaataagga gggctccgtg aagggcctta
     2521 gtggtccttc tgagcccagc cagatgagcc tcagtgactc cagcatgcca cctaccccag
     2581 ttacgcctgt aacccccacc acgccagcat tgcctacccc tatctctcct ccacctgtgt
     2641 cagcggtgag cagaagtggc tctaccactg tctctgagcc agccaagtct agttcaggtg
     2701 ttcttctggt gtcctcacca acaatgccac agctaggaac gatgctttcc cctgcttcca
     2761 tccagactcc gcccagttct cagaccactg ctcgggttgt cagccattcc agctcagcag
     2821 gactgcccca ggttcgggta gtagcccagc ccagccttcc tgctgtttcc cagcagtcag
     2881 tagggccagc acagccacta ccccagatgc cagcaggacc acagatccgt gtgccagtca
     2941 ccgctaccca aaccaaagta gtaccccagg cagttgtggc tacagttcca gtcaaggggc
     3001 agactacagc ggcctctgtg caacggcctg gacctgcaca gacaggactt acagtgacga
     3061 gtcttcctgc tgcagttagc cccgggagca agacagccat gagttctcct gggagctctg
     3121 ctccaagtgc ctccacaacc gccgtcattc agaatgtcac aggacagaac atcatcaagc
     3181 aggtgtcaat cactggacag cttggtgtga agccccagac aggcaacagc attccactca
     3241 cagccacaaa cttccgtatc cagggtaaag atgtactgcg cctgccgcct tcttccatca
     3301 ccacagatgc caagggccag acggttctga gaatcactcc agacatgatg gccacactgg
     3361 ccaagtctca ggtcaccaca gtcaagttga ctcaggacct ctttggggca ggtagcggca
     3421 ctgcaggcaa aggcatctct gctaccttgc atgtgacttc caaccctgtc catgcggctg
     3481 acagccctgc caaggcccct tcagccagtg ttccttcatc agctccagcg ggcactaccg
     3541 tggtcaaagt aactcctgat ctcaagccaa cagaaacctc cagttcagct tttcgcttga
     3601 tgccagctct tggcgtgagt gtggcagatc agaaggggaa gaacacagtg gcctcttcag
     3661 aagcaaaacc tgctgccaca atccgcattg tgcaggggct gggagtgatg cctcctaaag
     3721 caggccagac cattactgtt gcagcacatg caaagcaagg agcctctgtt gctggtgggt
     3781 ctggaactgt ccattcttca actgtgtcct tacccagtat caatgccact gtgtctaaga
     3841 ctgtggctgt ggcttctgga gcaacaagca cccccatcag catcgggact ggagccccca
     3901 ccgtgcgaca ggttcctgtt aacactacag ttgtgtccac atcccagtct gggaagctgc
     3961 ctaccaggat cacagttcct ctctctgtga ttagccagcc aatgaagggc aagagcgtgg
     4021 tcacagcccc catcatcaaa ggcaaccttg gagccaatct cagtgggctg ggtcgcaaca
     4081 tcatcctcac aaccatgcca gcgggtgcta agctcattgc tggcaataag ccagtgagtt
     4141 tcctcaccgc ccagcagttg cagcagcttc agcagcaagg tcaggctaca caggtacgca
     4201 tccagactgt gccagcatcc catctgcaac agggcacagc ttccggctcc tccaaagccg
     4261 tgtccactgt tgttgtgacc acagctccat ctcctaaaca agcacctgag cagcagtgac
     4321 tgagaagaaa ggcggcttct ttaagagacc aggcctggtt tatctcggct gacagaaagg
     4381 gagcagggag gctgcaccat tcttctgagc tgtcctgctt gaggcagggt ggtggagagt
     4441 gatggcaact gtggcctaga ttgtgctgcc acactccaga gtgaagccct ttttagggtt
     4501 ccagggatga tctgttatcc tggactacca ggaagaggga aggaacatca gagtctgggg
     4561 aggtcacagt cacacaagcc ggggttacct cctgaatgtt gggttcccag ggagcaggcc
     4621 tgccagttgg tgagtggacc ggcagggaat aagcctcatt ctgtgtgagg attttacttt
     4681 ttagtttctg atcttctccg tgacttgttg agatgtgagt tttgtgtcca gagaattttt
     4741 gtgtaactta tttttttaaa gaacctactc tacgtctttt atcaaataga aacctgggct
     4801 tcagtgcccc taaactgatc acttacccct tcaaccagaa tgagagcata gcaagactct
     4861 taatagtttg gcggcttact tgataatgga gaggttatat agtaagaaaa tgtaggcctt
     4921 gagttagcat ggaccccctc aagtgggact agttcaatgc cgtgtactaa atatgggcat
     4981 ctgaatctcg gttgtcccta tgtcttctct tgtgggcatt gtccttgaca agcctgttca
     5041 tggaagttca gagcttttgg acaggagtag gggaagatga ggtgctgctc tcaccgtgca
     5101 cttgcttaca gcccagacat tgcacattct ccttgctgta gaacagccat tgctaaccag
     5161 acccttggag ctggccactt gactgggaca gagaagaaat ggggaggtgg gggcaggggt
     5221 aggcactgcc tggcagtgcc atcttgaggg gaaaggatgt ttttattctg gccatttcat
     5281 atttctcagc caccaccagc cacagacagg gctcagaagg gtactttaca aagtccaagt
     5341 acttaatgta ctaggtgtat cttaacgtgt cttgctgtgg tgcaggggtg ggtaggaaaa
     5401 cctttctgca gggatagtgc ttccctgtct ctttgtgaaa atatccaaat tattaaaaac
     5461 atatctttaa
//
LOCUS       NM_001436488            3616 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 6,
            mRNA.
ACCESSION   NM_001436488 XM_063265250
VERSION     NM_001436488.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3616)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265250.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1808673.1,
                                           SRR26360176.1190171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000008.1  118095904-118096260
            358-481             JAXUCZ010000008.1  118096976-118097099
            482-811             JAXUCZ010000008.1  118106884-118107213
            812-1843            JAXUCZ010000008.1  118112261-118113292
            1844-2021           JAXUCZ010000008.1  118120474-118120651
            2022-2176           JAXUCZ010000008.1  118121209-118121363
            2177-2291           JAXUCZ010000008.1  118122735-118122849
            2292-2400           JAXUCZ010000008.1  118131517-118131625
            2401-2552           JAXUCZ010000008.1  118131953-118132104
            2553-2643           JAXUCZ010000008.1  118132470-118132560
            2644-3616           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3616
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..357
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            358..481
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            482..811
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    488..490
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             503..2836
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423417.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <518..646
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <518..646
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    2300..2782
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    2300..2782
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            812..1843
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2021
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2176
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2291
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2400
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2552
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2643
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..3616
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctcagc tgtggcccgt gggctagaac ggcttccggg gcgcgcgctt ccccgcgacc
       61 cccagttttg tggcgcgcgc cctgctgttg gtttggttgc tcgcgctgtc cggagtacgc
      121 gcaggacgcc ccttccgaga ggagggtcgg cggcctggct gacgaccggc ttgctgagtg
      181 gggaaggttg agggttgggc ccttgccctc gtgacgtccc gggcagcggt ggcctaggtc
      241 tgcggagaaa catagcggct ttgcggtctg gcttgcggct ccgctcctcc gtgaggcgga
      301 caggattgct tgtactaacc gaagaatgct gttacttaag cgaggcccat gtactggaac
      361 aaagttaaaa cttaaaaaga ggctgaggat ggaaggaact tctttgttct atcttcttca
      421 gaatgttaga agtcttaaga actcaggaca agcagcagac atacatgcaa catggtgact
      481 ggaaccctaa ggactctgca atatgaataa ttctctagag aacaccatct catttgaaga
      541 gtacatccga gtaaaggcga ggtctgtccc gcaacacagg atgaaggaat ttctggactc
      601 gctggcttct aagggaccag aagctcttca ggagttccag cagtctgcca ccaccaccat
      661 ggtgtaccag cagggtggga actgcattta tacagacagc actgaagtgg ctgggtcttt
      721 gcttgaactt gcttgtccag tcacaaccag tgttcaacca caaactcagc aagagcagca
      781 gatccaggtt cagcagccac agcaggttca ggtacaggtg caggtacagc agtctccaca
      841 gcaggtctca gctcagcagc tttccccgca gttcaccgtt caccagcctg ctgagcaacc
      901 catccaggtc caggtgcaga tccagggcca agcaccacag tccgcagccc cctccatcca
      961 gactccatca ctgcagagcc ccagcccctc gcagctgcaa gcagcccaga tccaggtgca
     1021 gcacgtgcag gcagcgcagc agatccaggc tgcagaaatc ccagaggagc atatcccaca
     1081 tcaacagatc caagctcagt tggtggcagg ccaatctctt gctgggggcc agcagattca
     1141 aattcagacc gtgggcgctc tttccccacc accctcccag cagggctcac ccagggaagg
     1201 ggagcggagg gttggcacag ccagtgtcct tcaaccagtg aagaaacgca aagtggacat
     1261 gcccatcacc gtgtcctatg ccatctcagg gcagccagtg gccaccgtgc tggccattcc
     1321 acaaggccag caacagagtt acgtgtcttt gaggccagac ttactgacag tagacagtgc
     1381 ccacctgtac agcgccactg ggaccataac tagccctaca ggagaaactt ggaccatccc
     1441 tgtttattcc gcccagcccc ggggggaccc tcagcagcag agcattaccc acattgccat
     1501 tccccaggaa gcctacaatg cagttcacgt cagtggctca cccacggctc tggcagctgt
     1561 aaagctggag gatgacaagg agaagatggt gggcaccaca tccgtagtga agaactccca
     1621 tgaagaggta gtgcagaccc ttgcaaactc tctctttcca gcacagttca tgaatggcaa
     1681 catccacatt ccagtggctg tgcaggctgt agcaggcacg taccagaata cggctcagac
     1741 tgtacatata tgggacccac agcagcagcc gcaacagcaa actgcacaag aacagacacc
     1801 accacagcca cagcaacagc agcagctgca ggtcacttgt tcagcacaaa ctgttcaggt
     1861 cgctgaagtt gagccacagt cacaaccgca gccttcacca gagcttttgc ttccaaattc
     1921 actgaagcca gaagaagggc tagaagtatg gaaaaactgg gctcagacca agaatgctga
     1981 actagaaaag gatgctcaaa acagattggc ccccattggg aggcgccagt tgctacgatt
     2041 ccaagaagat ctgatctcat ctgctgtggc tgaattgaat tatggccttt gtttaatgac
     2101 acgagaagct cggaatggag aaggtgaacc ctatgaccca gatgtactct actacatttt
     2161 cttgtgtata cagaagtatc tttttgaaaa tggaagagta gatgacatat tctctgatct
     2221 ttactatgtt cgttttaccg aatggctaca tgaagttctg aaggacgtgc agccccgggt
     2281 cactccactt ggctatgttc tgcccagcca cgtgactgaa gagatgctgt gggaatgcaa
     2341 gcagcttggg gcacattccc cttcgacact gctgaccacc ctcatgttct tcaacaccaa
     2401 gtactttctg ttgaagacag tagatcagca catgaagctg gcgttctcca aggtcctccg
     2461 gcagacaaag aagagcccct cgaatcctaa ggataaaagc actagtatcc gctacctgaa
     2521 ggccctcgga atacatcaga ctggccagaa agttacagat gacatgtatg cagaacagac
     2581 agaaaatcca gagaacccat taaggtgtcc catcaagctc tacgatttct acctcttcaa
     2641 atgcccccag agtgtgaaag gccgaaatga caccttttac ctgactcctg agcctgttgt
     2701 ggctcccaac agcccgatct ggtactcagt ccagcctatc agccgagagc agatgggaca
     2761 gatgctgacc cggatcctgg ttatacgaga gattcaagaa gccattgccg tggccaacgc
     2821 aaccaccatg cactgaggtg cctcagccac aggaaaaaaa aaaatccagg aaaaaccaga
     2881 cagactttta cactaaagga gaggcctcca tttttttctt tttctttttc cttcaattcg
     2941 tagttctaat gcttttcagg cgacttctgt taaaaatgta aaagacaatg ttgccctctt
     3001 tgcatcttca taaaatgggc agaccccctg gttcatgggt atatggtttt cctagaactt
     3061 gatgtcctag gaagtggttg gcttttacct ttcttttcct tttttttctt ttgtctgggc
     3121 tggagtgtgg gggaagggac ttggactgta tggagaaata taggcccttc ccttcctcaa
     3181 ggcagatgga gcagccgatg aatcaaccct cctgcaaacc cccacctttc actctggacc
     3241 ggcaggctta accactcgga gccacgattt ttcttttttt tttttttttt ttttttttta
     3301 aatgctcaga cataaactta gcatcttgat ggaataaaaa tgaggggaac ttcaattatg
     3361 atttttatta aagacaattt ctattacacc cttctttatg acaagtgaca tagatgttaa
     3421 agtaaaaact ttaccatgct tttttttttt tttttttttt tttttggcct aacattgagg
     3481 ccttaaacct gaggctcctg tgcctgatgg aattcttgta acatacactt gtgtatcata
     3541 taaagatacc actctttctc ttatgtattc ttattctagt tgtttattaa gaatgacaag
     3601 cacgtctttt caacaa
//
LOCUS       NM_001034942            8717 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 44
            (Zbtb44), transcript variant 1, mRNA.
ACCESSION   NM_001034942 XM_343366
VERSION     NM_001034942.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8717)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 8717)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001034942.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.31088.1, BC104680.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000008.1  37724537-37724791
            256-1329            JAXUCZ010000008.1  37747440-37748513
            1330-1414           JAXUCZ010000008.1  37768061-37768145
            1415-1578           JAXUCZ010000008.1  37770183-37770346
            1579-1662           JAXUCZ010000008.1  37772485-37772568
            1663-8717           JAXUCZ010000008.1  37775166-37782220
FEATURES             Location/Qualifiers
     source          1..8717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..8717
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="zinc finger and BTB domain containing 44"
                     /db_xref="GeneID:363035"
                     /db_xref="RGD:1308984"
     exon            1..255
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            256..1329
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    264..266
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="upstream in-frame stop codon"
     CDS             312..1673
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 44; BTB/POZ
                     domain-containing protein 15; BTB (POZ) domain containing
                     15"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 44
                     isoform 1"
                     /protein_id="NP_001030114.1"
                     /db_xref="GeneID:363035"
                     /db_xref="RGD:1308984"
                     /translation="MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDRIFRA
                     HKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENII
                     DVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENSSNCNFTSRDGSI
                     SPVSSECSAVERTIPVCRESRRKRKSYIVMSPESPVKCSTQTNSPQVLNSSASYAENR
                     NQPVDSSLAFPWTFPFGIDRRIQPEKAKQAENTRTLELPGPSEAGRRMADYVTCESTK
                     TTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEPVQEDLLISP
                     QSSSIGSVDEGVTEGLPTLQSTSSTNAHADEDDRLENVQYPYQLYIAPSTSSTERPSP
                     NGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDCCGKKFTRAYSLKMHRLKHE
                     VIS"
     misc_feature    354..701
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 44 (ZBTB44); Region:
                     BTB_POZ_ZBTB44; cd18228"
                     /db_xref="CDD:349537"
     misc_feature    354..701
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 44 (ZBTB44); Region:
                     BTB_POZ_ZBTB44; cd18228"
                     /db_xref="CDD:349537"
     misc_feature    714..716
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCP5; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    786..788
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    792..794
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    804..806
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    882..884
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    891..893
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    906..908
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    909..911
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    918..>1277
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="outer membrane protein PgaA; Provisional; Region:
                     pgaA; PRK10049"
                     /db_xref="CDD:236644"
     misc_feature    918..>1277
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="outer membrane protein PgaA; Provisional; Region:
                     pgaA; PRK10049"
                     /db_xref="CDD:236644"
     misc_feature    1032..1106
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1194..1283
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1317..1415
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1506..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1512..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1512..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1548..1625
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1548..1625
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1596..1658
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1596..1658
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1330..1414
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1578
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1662
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..8717
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctcgcac ctcgcgtgca cgcgggtgag cggcgccgcc atgcgcgccc agtcccaggc
       61 tgcacactgg cctaggcgcg gcggcccgag atagggtccc ctgagcctcc cgggggagga
      121 gaggagccag ccgcgcgctc cgccccctcc ccccgggttg ccgccgctac cgccaccgcc
      181 acctcgccgc cccagcctgg cggggaagag gaggagcagt tgcaggcctc cgggcccccg
      241 caccgccgcc cgcagggtaa ttctgattca ttgcatcctt gaagagcatc aatagaagag
      301 ggggaaaaaa gatgggtgtg aaaacattta ctcacagctc ctcttcccac agccaggaaa
      361 tgctgggaaa actaaatatg ctacgaaatg acggacattt ttgtgatatc actattcgtg
      421 tccaggacag aatcttccgg gctcacaagg tggtactagc agcttgcagt gatttctttc
      481 gaaccaaact tgtgggccaa acagaggatg agaacaaaaa tgtgttggat ctgcatcatg
      541 ttacagtgac tggctttata cctctgctgg aatacgctta cacagccact ctgtccatta
      601 acacggaaaa tattattgat gttctagcag cagccagcta tatgcaaatg tttagtgttg
      661 ctagtacgtg ctcagagttc atgaaatcaa gtattttgtg gaatacacct aatagccaac
      721 cagaaaaggg tctagatgct ggacaagaaa atagttccaa ctgcaatttt acttctcgag
      781 atggaagcat ttctccagtg tcttccgagt gcagtgctgt ggaaaggacc attcctgtct
      841 gccgagagtc ccggagaaaa cgcaaaagct acattgttat gtctcctgag agccctgtaa
      901 aatgtagcac acaaacaaat tccccccagg tactgaattc ttcagcttcc tatgcagaaa
      961 atagaaatca gccagttgat tcttctttag cgtttccatg gactttccct tttggaattg
     1021 ataggaggat tcagcctgag aaagcaaagc aggcagaaaa tacccggact ttagagttgc
     1081 ctggcccgtc cgaggcaggt agaaggatgg ctgactatgt gacttgtgag agcacaaaaa
     1141 ctaccttgcc tctaggtaca gaagaagacg tccgggtcaa agtagaaaga ttaagtgatg
     1201 aggaggttca tgaggaagtg tcccagcccg ttagtgcatc tcagagctca ctgagtgatc
     1261 agcagacggt gcctggaagt gaaccagttc aagaggacct tctgattagt ccacagtctt
     1321 cctctatagg ctcagtggat gaaggagtca ctgaaggatt gcctacactt cagagcactt
     1381 ccagcaccaa tgctcatgca gatgaggatg acagattgga aaatgttcag tatccctatc
     1441 aactgtacat tgctccttct accagcagta cagaacgacc aagtccaaat ggtccagaca
     1501 gaccttttca atgtccaacc tgtggggttc gcttcacccg tattcagaat ctaaaacagc
     1561 acatgcttat ccactcagga attaaaccat ttcagtgtga ctgctgtgga aaaaagttta
     1621 ccagggctta ctcgctaaag atgcatcgcc taaagcacga agtgatttct tagtaccgga
     1681 ctacttaagc caggagcaag aagaggccct tgttcagtat gatcttggag agcacacttc
     1741 tgaaagcagc tcttctgttc aaatgcctgt gatttcacag gtctcctcaa cccacaactg
     1801 tgaaagcact tttcccctgg ggtctcttgg tgggcttgca gaaaaggagg aggacctgca
     1861 agagcagcca aagaccagtg ctcacgatga tgctccccga gatgaccccc ccaaggcaga
     1921 gctgtcttct ataactattg agtgattctg tgattggcct gggttttggg gtttttttgt
     1981 tttgttttgt ttgtttgttt gtttgtttgt tttggaaagt gcctgtgctt ggtctcatat
     2041 gtttaaattt aatttaattt tttaaaaagg ggttcccttt gtaagctctg aaactagagg
     2101 gttctttgtt ttgttttgtt ttttcatagc tttagtatgt atacaataag gtaacattga
     2161 aacagaacat aaactttaag agtaaggaaa agcagctgac ttagaacatg gcagttcttc
     2221 cattgttaaa agtgggcagc agcagataca aaagaagtcg ggttgttgtt gacctttctg
     2281 agataagagg gctaatgaga agttactaaa gagtttgaca aagcctaagg aatgtttact
     2341 cctggacaca gggtgttaga aaccctgtag ttttggaaga atttacggta tttttttttt
     2401 cagatgacgg taaataactt ctgaaatcca gtatattctt tttttttttt ttaagccatt
     2461 ttggattttc atggtgaaaa attagtatca ggcaggtatt ttctgtacct ttgtagtact
     2521 cctccaaagg ctaggtgtgg ttgagaagag tcaggcgcgc gtggaatggc agggcgcaga
     2581 acgaggtacg tatacccagc tttgcaggaa ctctcttcag actgtttttt ttactggcca
     2641 ttgactgctg acatctggtt aactaggaca ttgctcagat aagtgtcctc gtgtcccatc
     2701 aacagcactt tcacttgcat atatactatt gtgctgccat ataaaagaaa aatattgaag
     2761 atattctata ttttatatat aggtttatgt attgttgagg atgtcgatgc tgtgctgttt
     2821 tggacaaaat aaaagaattc tgttttgagg ctacattctt aacccaatta agattgttta
     2881 caagatcaca tttgacaaca atataatgtt cttattccaa aatattttaa ggtattgcca
     2941 agtttgttaa aagccgctat tacatagttt tcacaggatg tgagcaataa tgtgaaagat
     3001 aagaggtggt aaaatgatca tctatgactc aaaacttaga ggagcgattg ttaagactaa
     3061 gatctaaaaa ctttgctact cagatgataa aatttatatg atactctaga ttgggatata
     3121 cttttttatc tgctgccatt aaagcctctt tgatctgaag tattcatgaa tcaataaata
     3181 atgaacttat gtgtaatttt tttttttccc ggaactaggg accgaaccca ggcccttgca
     3241 cttgctaggc aagcgctcta ccgctgagct aaatccccag ccccgtaatt ttttatatag
     3301 aaagtagccc cagcatttat cattgtggta gcccctgatg gggttagaag ataaaaacta
     3361 catatgtttt tttgtttgac tttggatatt tgtaacagga tcataggtag cccaggttgg
     3421 tccagaactc atgatcctat tgcctcagtt cccccacaat gcttgttaac attacatatc
     3481 atagacacat caccacatcc agatcaagct atagtcttag tcaaacacat gatctgactt
     3541 ttaccccagt gccagacctt acttacttac actttatgtt ttagtaattt gtctctttaa
     3601 aatttattaa ttctgcaatt taatttctat ctctgtcctt ttttcttctt aatactgaga
     3661 gttgaaccca ggactttata tattatgagc atgtgctcta tcactagatc caaccccaac
     3721 ccgtatttct agttttttac ctgactcatt tgctcccaag cataagtgtg tgaccttcag
     3781 aaaagtcaac taaaagagtc agtaattttt attttattat catatgatct ttgaaaactg
     3841 tgcctactaa tacataaatc ctaaaactca ttagaatcct attttagtaa ggtaaatgtt
     3901 tttggttcta aactgggttt ttattttgtt aagagctaga aaaaggggaa aggaagaaag
     3961 aaataagagt aaatcagaga tgaattgatt tgaagaattc ttttgagatt tttggtgaaa
     4021 gtgtttcagt atgccctctc ctaggaattc tgaattagga cagccctgct agcttccctg
     4081 ggaaggacgt gcctcactgt ggattttcat tactagtgac aaatcttgga gccaacctta
     4141 atgagaaatt ccaatatact atgaatgcac aaatggttag atgcctactg cccaaatctt
     4201 tttgataaag ttacccgacc agtgtttttt tttttttttt ggttcttttt ttcggagctg
     4261 gggaccgaac ccagggcctt gcgcttccta ggtaagcgct ctaccactga gctaaatccc
     4321 cagcccccga ccagtgttta atataaaatg atacaaaggc ctttttctgt tccaatatga
     4381 ctctacattt tttgaggaca ttttgtttat gggtctatta taggaaatac aactgcaaga
     4441 gataattgta tatatagtaa tacttaaagt ttatttaaag ttgatttaag aggggaatgc
     4501 ctagatgtat acttttcacc agaacatatg gaaaacattg tgaagagatg aaagccagtt
     4561 aatgtgatcc catcatagaa atcaccaggg gaactaaaca gagaagcagt cttgtttaga
     4621 ataaatattt aaaggtagct atctttcgta aggcctacga gggtaacttt gtgatattta
     4681 aagggcttac attttagaat gctagataag ttacttttta aaaatctaag cattttatat
     4741 aagaaaagct ctgttttcaa tttttttcca actaccaaat agataggatg tgctttagag
     4801 gtaaagtctt caccgtgttg gaggcggtag cccctcctgt cagtctttgc atttccaaac
     4861 tccagcttca gagggtcacg tcaggacgcc actgactcag aaacagaaag ttaacaggac
     4921 actttacctt gtgcatttaa attttctaag aaatggatat tgataacgtt attatccaaa
     4981 aatatgtgag cttctcttaa ttggccattt taaacaatcc taatttttat tttgagtcta
     5041 atttcaagtt taaccacagt tcattattac taggttttat tttgagtttt tcaggggtgg
     5101 agtttaattt ttttttttaa gttcacaatt ttgttaagac agaatgtact aaaatgttta
     5161 agttgcttca tttcagtctt atgtttgaac atattaagtc ccaataaata ggatccgtgt
     5221 taagatacat tccctttgtt attaaaaaca aacagaaaat acttgttaaa atgttttact
     5281 aaatagagtg gaggagtaag ggcctctggt tcactgagtc attggttctc cagttgcctt
     5341 ctaactacgg agccaggctc tcctgtttta aaactgatcc ccattccttt agaagctatg
     5401 ttaagtcttt cactccttga aaaaaggctc tcctttcatt tgtctaatta atagaaggca
     5461 cttgcatggt gagtgtctgt tttcagatta ggcgttagtc tgttagcttt tctaaggtac
     5521 atgaccatac agtgttatgc agaggggatc ctctagcagg atctcagaca ctgttttctt
     5581 atgatggcaa atgagcagtc ctcaattcta actcgagaga ttttggtttg tagacctaat
     5641 gaccaggcga attagaaact tccattgtac tgcatcactc atctgcccaa agggccttca
     5701 aactgaagta tacacctaca tgaaggaatg atgtgagttc ttaactagga gtgggggaaa
     5761 agaactagga aagctcacat aatggagcag acagcccaaa ggtaggggag aaagataggt
     5821 tttcactgta aacgttgaca tcagacgcct ttttatattt ccatagttac taagagaaca
     5881 tatagaaacc agaaggcagt ggaacaaaag tgagggagta gagagatgtt attgttgtag
     5941 taaatacagc tatgaggaat atttataact aaatacatgt tttaaataag atcaaaatta
     6001 agatttctta ttttgcttat actagtattt atccactctt gtttttgaca gaatgtggtg
     6061 acgtgggata atttttacgt gaaaaatctt cagcaaaaca aatttaccaa aatagcaatg
     6121 ggtcagctaa acactggagt ggcattaagc cagtccgcaa gccggttaag aagtaggctg
     6181 taatgtttca ctccggaatg cataacttga gatgtttgct gcaacctaga aacatgaact
     6241 gtgtagaaca gggaatgctg ctgggcacta ccaggagtta ctgaagtgat gagtgagatg
     6301 ctttcccata tcgtaattct ggtttataat agaagcgata gttccatggt tttggaagta
     6361 gtcactgtag attccagaca gtccagttgg agccttggct ttggcagtgt ctgaacatgt
     6421 tgctttaact gctccttcaa ctttagcagt gctccctgag tgaaacccag gccggttcca
     6481 gcagacaccg ggcttcctgt ggacataaca gtttacaaaa acttaggagt tcagaccctg
     6541 attgagaaac attaaaatta atgtttttat taaaagtata agagaaaatt aagttttttt
     6601 aagtgcctaa tttataaagt taaattcttt atttctaagt tatcaagctt tgctaagcct
     6661 aaaaaccctg ggctcagttg tgatgattta ctagtaaagt caccagtaat catttgagga
     6721 gctatagtgt catgactttt actaaattcc ttgttttctc aaatggcaga ctgactatac
     6781 ctagagcttg aaaagtcacc ctgtgagtga gttcattacc aaagcccgtc acctgctgag
     6841 tagtcagcgc tgtctgcaca ggagggagta gtgtggcttc aagatggcag cattgtccgc
     6901 agtggtgttt tccagagagc cttttctgtg agtagtgtgt gcgtgccctc tgagcttgtc
     6961 ctgttaggta gccgttctcc ggttgacagc tgatatgaag gtctttggca ctgagaatgc
     7021 agttttgaaa gttgcactgc ttttctgccc cctagagtga gtggcattgg atatttagaa
     7081 gtgaggccat aaacttgtta ctttgtttat acaaaatgat ggcttccgat gcttatgtat
     7141 ggaagtattg cttaaagaac agcctctgat aaggtaaaat ctggttttga ctcaagttct
     7201 aatgatgtat ttagtttatt gatactggtg tctcctgttg catcagctag atattgcctg
     7261 cctctttgtt aaggcaccct gtggcacctt acgttcaact tgaaggatgg tatgtggcct
     7321 ctttgtgcct ctactgtctt ttcaaaagcc attttataaa aatcttaggt attttaatat
     7381 ttaaatatat atatttgtga aagatacttt tagaacgaat tttttttaac tttaaagttc
     7441 ctgtattccc atttttaaga gtaaactaaa gattttccag gcttaggagt atcttttttc
     7501 agaaccgtga taagaaagtc agattgaggt aataaaccag agagtttgat gatagggaaa
     7561 aagatatctg gtgaggggag acagatttaa aggtgaaaac aattactttg atgtaacaaa
     7621 ttaacttctt aaataaagtt ttgtggtttt gctcctgtga tttcgtattt gctgctatag
     7681 tagctcacta ttttataggg ctaatatata aatctggccc catttaaaac tgaggtcctt
     7741 tctaatccaa acagcctaga aagagactgc agcacagtct gccagcggtg gccagtgtcc
     7801 atatagctga tgcatgcttt aatgtttgcc tgtagctggc agcacggagg tcagggaagc
     7861 ttcctaccct gccagacaga gcattatgat tcttggggga ctggcatctg ggagacaaga
     7921 caggccaaag agggaaccgc tgaggagagc gtgtgaatgc agttgcatgt tcccatgttc
     7981 tcctatagca gtcctactct ccagctgcgc cagtccccat gtcaccagct ctgtaccagt
     8041 tgtcatctca ttcaagtgtg gctttacttg gtgacagtgg ccatagctaa attacttagc
     8101 atgtttgact ttctacaata acaaaaatgg tcttaaattt ttgttttgat ttcctaaaaa
     8161 aaatgtacac agtgtcataa cttcacgttt tataaactag tatctggcta ttagtatttt
     8221 acagaaacca tggttcttgg tgactacata tatatatata tatatttttg tgaccttttt
     8281 gtaaactaag tgccgtttca acgttacaat catttttaga gttattgtaa tcaatgtgaa
     8341 tatcatgttt tttcaaatct gttctgagcc tagtgtttgc tttgtgaaaa atatgtgtat
     8401 tgtatatatt ctgtatagtt atactgtatt gaaatattag cttgtttgat atgagaaaaa
     8461 gtatgtattg agtacctttt tgctagcctg attgcttaat cttttttaaa aaggtttaat
     8521 tttttttttt taatctttaa actggccttt attaatggtc acaaataaag ttgcagttag
     8581 aagggatgga cagggaaaat ttagtcttga gtgtctttgg atagaaacat gagactaaga
     8641 tttgtttcgg gttttttgtt tgtttttgtt tttgtttttt ttttctcatt aaaatacctt
     8701 actgatgttt tatgaaa
//
LOCUS       NM_001436492            5185 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 2, mRNA.
ACCESSION   NM_001436492 XM_063265378
VERSION     NM_001436492.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5185)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5185)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5185)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265378.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2727970.1,
                                           SRR26643295.31140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000008.1  38090030-38090098
            70-242              JAXUCZ010000008.1  38092744-38092916
            243-444             JAXUCZ010000008.1  38095209-38095410
            445-572             JAXUCZ010000008.1  38098165-38098292
            573-747             JAXUCZ010000008.1  38099310-38099484
            748-885             JAXUCZ010000008.1  38099986-38100123
            886-959             JAXUCZ010000008.1  38100738-38100811
            960-1044            JAXUCZ010000008.1  38101595-38101679
            1045-1225           JAXUCZ010000008.1  38102404-38102584
            1226-1334           JAXUCZ010000008.1  38103121-38103229
            1335-1461           JAXUCZ010000008.1  38103788-38103914
            1462-1524           JAXUCZ010000008.1  38104180-38104242
            1525-1604           JAXUCZ010000008.1  38105285-38105364
            1605-1651           JAXUCZ010000008.1  38105453-38105499
            1652-1712           JAXUCZ010000008.1  38106233-38106293
            1713-1887           JAXUCZ010000008.1  38106533-38106707
            1888-1994           JAXUCZ010000008.1  38108447-38108553
            1995-2118           JAXUCZ010000008.1  38110471-38110594
            2119-2198           JAXUCZ010000008.1  38111060-38111139
            2199-2413           JAXUCZ010000008.1  38111280-38111494
            2414-2684           JAXUCZ010000008.1  38111574-38111844
            2685-2897           JAXUCZ010000008.1  38112380-38112592
            2898-3665           JAXUCZ010000008.1  38114925-38115692
            3666-3772           JAXUCZ010000008.1  38118990-38119096
            3773-3908           JAXUCZ010000008.1  38119994-38120129
            3909-5185           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5185
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..69
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            70..242
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    84..86
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             108..4034
                     /gene="Nfrkb"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 2"
                     /protein_id="NP_001423421.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEATLDL
                     QEKFSFEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKH
                     HEKRKHQPDHPDLLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKK
                     IKLIKSEAEDLAEPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFF
                     SLLLEILLLESQASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGES
                     RVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDA
                     MTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFD
                     KETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPD
                     VTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAK
                     ARKALQQKPKPPSKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPAL
                     PTPISPPPVSAVSRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQT
                     TARVVSHSSSAGLPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKV
                     VPQAVVATVPVKGQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSAS
                     TTAVIQNVTGQNIIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTD
                     AKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAAD
                     SPAKAPSASVPSSAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVAS
                     SEAKPAATIRIVQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINAT
                     VSKTVAVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPM
                     KGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQ
                     GQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1317..1574
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1317..1574
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2187..2801
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2187..2801
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3123..>3659
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    <3123..>3659
                     /gene="Nfrkb"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            243..444
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            445..572
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            573..747
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            748..885
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..959
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1044
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1225
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1334
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1461
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1524
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1604
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1651
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1712
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1887
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1994
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2118
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2198
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2413
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2684
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2897
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3665
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3772
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3908
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..5185
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggagcga gcgcgtccgg gagcccacgg ccggacgagc cccgggtgag acccgcggac
       61 ccggctgagg gtgtattttt aggtagtgta cctgtggaga agaaacaatg gattccttgg
      121 atcacatgct gacagatccc ctagaacttg gtccttgtgg agatggtcac agtacaggga
      181 tcatggagga ctgccttctg ggtggaacca gggttagtct gcctgaagac ctgctggagg
      241 atcctgaaat attctttgac gtcgtcagcc tctccacatg gcaggaagta ctaagtgact
      301 ctcagcgtga acatctccag cagtttctgc cgcagtttcc tacagacact gtagagcagc
      361 agaatgagct catccttgcc ctattcagtg gggagaactt ccgcttcgga aaccctctgc
      421 acatcgccca gaagctcttc cgagatggac actttaaccc tgaggtggtc aagtatcggc
      481 agctctgctt caagtcacag tacaagcggt acctcagctc ccaacagcag tatttccacc
      541 ggctgctgag acagattctt gcttccagaa gtgatctcct ggagatggct cgcacgagcg
      601 gcccggctct tccctttcga cacaagcacc attcaccatc ccgaagcccg gaggagcggg
      661 agtggcggac ccagcagcgt tacctgaaag tcttgaggga agtgaaggag gagtgtggcg
      721 acactgccct gtcgtctgat gaggaggcca cgttggattt acaagaaaaa ttttcttttg
      781 aagatctcag ctcatggctt ccaagctctc cagcacgctc tcctagtcct gcggtgcccc
      841 tgagggtggt gcccacgctt tccaccacgg atatgaaaac tgcagataaa atagaactgg
      901 gggacagtga cctgaagtta atgttaaaga aacaccatga gaagcggaaa catcaaccag
      961 atcacccaga ccttttgaca ggggatctga ctctcagcga catcatgact cgagtaaatg
     1021 ccggcaggaa gggctctcta gcagccttgt atgatttggc tgttcttaaa aaaaaggtga
     1081 aggaaaagga ggagaagaaa aagaagaaaa taaagttgat taaatcggag gcagaggatc
     1141 tggctgagcc cctaagcaat actgaagggg tcccaacgct ctcccaggcc ccctctcccc
     1201 tggcaatatc gtctatcaag gaagaacccc tggaagacat caagccttgt cttggaatca
     1261 atgaaatatc ttccagtttt ttctctcttc tgttagagat cttgctgctg gagagtcagg
     1321 ctagccttcc tatgctggag gaccgggttt tggattggca gtcttctcca gccagctccc
     1381 tcaacagctg gttctctgct gcccccaact gggctgagtt ggtgttgcct gctctgcagt
     1441 atcttgctgg agaaagccga gttccttcca gtttttctcc atttgttgaa ttcaaagaga
     1501 aaacccagca gtggaaattg cttggtcaat ctcaagataa tgaaaaggaa ttagccgctc
     1561 tcttccactt gtggctagaa accaaagacc aggctttctg taagcaggaa aatgaagaca
     1621 gctcagatgc catgacacct gtgcctcgag taagaactga ctatgtggtt cggcctagca
     1681 caggagagga gaaacgggtt tttcaagagc aggagcgtta caggtatagc caaccccata
     1741 aggcattcac ctttcgcatg catggctttg agtctgtggt ggggccagtg aagggcgtgt
     1801 ttgacaagga gacctccctc aacaaggctc gtgagcactc actgctgcgc tctgaccggc
     1861 ctgcctatgt caccattctg tctcttgttc gggatgctgc ggctcggctg cctaatggag
     1921 aaggcactcg ggcagagatc tgtgagctgc tcaaggactc tcagtttctt gctcctgatg
     1981 tcaccagcac tcaggtgaac acggtagtga gtggcgcact ggatcgattg cattatgaga
     2041 aggacccttg tgtgaaatac gacattggtc ggaagctgtg gatctacctg catcgtgacc
     2101 ggagtgagga agagtttgaa cggatccatc aagctcaagc agcagcagct aaagccagaa
     2161 aagctcttca gcaaaaaccc aaaccgccat ccaaggtgaa gtccagtaat aaggagggct
     2221 ccgtgaaggg ccttagtggt ccttctgagc ccagccagat gagcctcagt gactccagca
     2281 tgccacctac cccagttacg cctgtaaccc ccaccacgcc agcattgcct acccctatct
     2341 ctcctccacc tgtgtcagcg gtgagcagaa gtggctctac cactgtctct gagccagcca
     2401 agtctagttc aggtgttctt ctggtgtcct caccaacaat gccacagcta ggaacgatgc
     2461 tttcccctgc ttccatccag actccgccca gttctcagac cactgctcgg gttgtcagcc
     2521 attccagctc agcaggactg ccccaggttc gggtagtagc ccagcccagc cttcctgctg
     2581 tttcccagca gtcagtaggg ccagcacagc cactacccca gatgccagca ggaccacaga
     2641 tccgtgtgcc agtcaccgct acccaaacca aagtagtacc ccaggcagtt gtggctacag
     2701 ttccagtcaa ggggcagact acagcggcct ctgtgcaacg gcctggacct gcacagacag
     2761 gacttacagt gacgagtctt cctgctgcag ttagccccgg gagcaagaca gccatgagtt
     2821 ctcctgggag ctctgctcca agtgcctcca caaccgccgt cattcagaat gtcacaggac
     2881 agaacatcat caagcaggtg tcaatcactg gacagcttgg tgtgaagccc cagacaggca
     2941 acagcattcc actcacagcc acaaacttcc gtatccaggg taaagatgta ctgcgcctgc
     3001 cgccttcttc catcaccaca gatgccaagg gccagacggt tctgagaatc actccagaca
     3061 tgatggccac actggccaag tctcaggtca ccacagtcaa gttgactcag gacctctttg
     3121 gggcaggtag cggcactgca ggcaaaggca tctctgctac cttgcatgtg acttccaacc
     3181 ctgtccatgc ggctgacagc cctgccaagg ccccttcagc cagtgttcct tcatcagctc
     3241 cagcgggcac taccgtggtc aaagtaactc ctgatctcaa gccaacagaa acctccagtt
     3301 cagcttttcg cttgatgcca gctcttggcg tgagtgtggc agatcagaag gggaagaaca
     3361 cagtggcctc ttcagaagca aaacctgctg ccacaatccg cattgtgcag gggctgggag
     3421 tgatgcctcc taaagcaggc cagaccatta ctgttgcagc acatgcaaag caaggagcct
     3481 ctgttgctgg tgggtctgga actgtccatt cttcaactgt gtccttaccc agtatcaatg
     3541 ccactgtgtc taagactgtg gctgtggctt ctggagcaac aagcaccccc atcagcatcg
     3601 ggactggagc ccccaccgtg cgacaggttc ctgttaacac tacagttgtg tccacatccc
     3661 agtctgggaa gctgcctacc aggatcacag ttcctctctc tgtgattagc cagccaatga
     3721 agggcaagag cgtggtcaca gcccccatca tcaaaggcaa ccttggagcc aatctcagtg
     3781 ggctgggtcg caacatcatc ctcacaacca tgccagcggg tgctaagctc attgctggca
     3841 ataagccagt gagtttcctc accgcccagc agttgcagca gcttcagcag caaggtcagg
     3901 ctacacaggt acgcatccag actgtgccag catcccatct gcaacagggc acagcttccg
     3961 gctcctccaa agccgtgtcc actgttgttg tgaccacagc tccatctcct aaacaagcac
     4021 ctgagcagca gtgactgaga agaaaggcgg cttctttaag agaccaggcc tggtttatct
     4081 cggctgacag aaagggagca gggaggctgc accattcttc tgagctgtcc tgcttgaggc
     4141 agggtggtgg agagtgatgg caactgtggc ctagattgtg ctgccacact ccagagtgaa
     4201 gcccttttta gggttccagg gatgatctgt tatcctggac taccaggaag agggaaggaa
     4261 catcagagtc tggggaggtc acagtcacac aagccggggt tacctcctga atgttgggtt
     4321 cccagggagc aggcctgcca gttggtgagt ggaccggcag ggaataagcc tcattctgtg
     4381 tgaggatttt actttttagt ttctgatctt ctccgtgact tgttgagatg tgagttttgt
     4441 gtccagagaa tttttgtgta acttattttt ttaaagaacc tactctacgt cttttatcaa
     4501 atagaaacct gggcttcagt gcccctaaac tgatcactta ccccttcaac cagaatgaga
     4561 gcatagcaag actcttaata gtttggcggc ttacttgata atggagaggt tatatagtaa
     4621 gaaaatgtag gccttgagtt agcatggacc ccctcaagtg ggactagttc aatgccgtgt
     4681 actaaatatg ggcatctgaa tctcggttgt ccctatgtct tctcttgtgg gcattgtcct
     4741 tgacaagcct gttcatggaa gttcagagct tttggacagg agtaggggaa gatgaggtgc
     4801 tgctctcacc gtgcacttgc ttacagccca gacattgcac attctccttg ctgtagaaca
     4861 gccattgcta accagaccct tggagctggc cacttgactg ggacagagaa gaaatgggga
     4921 ggtgggggca ggggtaggca ctgcctggca gtgccatctt gaggggaaag gatgttttta
     4981 ttctggccat ttcatatttc tcagccacca ccagccacag acagggctca gaagggtact
     5041 ttacaaagtc caagtactta atgtactagg tgtatcttaa cgtgtcttgc tgtggtgcag
     5101 gggtgggtag gaaaaccttt ctgcagggat agtgcttccc tgtctctttg tgaaaatatc
     5161 caaattatta aaaacatatc tttaa
//
LOCUS       NM_001436466            3627 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus IQ motif containing H (Iqch), transcript variant
            2, mRNA.
ACCESSION   NM_001436466 XM_017595563
VERSION     NM_001436466.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_017595563.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1383106.1,
                                           SRR26643293.45839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000008.1  72978476-72978591   c
            117-239             JAXUCZ010000008.1  72965283-72965405   c
            240-328             JAXUCZ010000008.1  72964734-72964822   c
            329-443             JAXUCZ010000008.1  72954872-72954986   c
            444-560             JAXUCZ010000008.1  72940310-72940426   c
            561-681             JAXUCZ010000008.1  72914785-72914905   c
            682-810             JAXUCZ010000008.1  72911713-72911841   c
            811-932             JAXUCZ010000008.1  72901945-72902066   c
            933-971             JAXUCZ010000008.1  72900132-72900170   c
            972-1523            JAXUCZ010000008.1  72891516-72892067   c
            1524-1590           JAXUCZ010000008.1  72890677-72890743   c
            1591-1766           JAXUCZ010000008.1  72875386-72875561   c
            1767-2039           JAXUCZ010000008.1  72866121-72866393   c
            2040-2231           JAXUCZ010000008.1  72861335-72861526   c
            2232-2352           JAXUCZ010000008.1  72848274-72848394   c
            2353-2639           JAXUCZ010000008.1  72845413-72845699   c
            2640-2810           JAXUCZ010000008.1  72819954-72820124   c
            2811-2933           JAXUCZ010000008.1  72811070-72811192   c
            2934-2995           JAXUCZ010000008.1  72795168-72795229   c
            2996-3104           JAXUCZ010000008.1  72791557-72791665   c
            3105-3627           JAXUCZ010000008.1  72787701-72788223   c
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3627
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ motif containing H"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
     exon            1..116
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    6..8
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="upstream in-frame stop codon"
     CDS             66..3239
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="isoform 2 is encoded by transcript variant 2; IQ
                     domain-containing protein H"
                     /codon_start=1
                     /product="IQ domain-containing protein H isoform 2"
                     /protein_id="NP_001423395.1"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
                     /translation="MAQAQELNDPIGSILIQVHGDLHQLKEKLIQFSAEETRDPLDIQ
                     NLETAIQRTETGLKIHIERYLGIVNQEVIMTPVKSLDSPINSKWAIPTVIDQKSFIFP
                     MAPDKLWGLQKHRGSLPRGFTRAKPKVELNKKIMQDPENMHHRAAVNVSYGISLPRIK
                     QRKAHDKVRRVRKGSTISNLTVLPSSHRTDPHFIPIPVLQKDASKGILSMIERGLIPP
                     AARITFQNPPIKPQALPLHSFDEHRKVSITASFPIAHKPRLASEKVEESQQKQKAKVL
                     THLSTEEHSLPVTGKDKRSRGQPSRKSTRITTPSRIRRSPWDYILPVYNGSVDRAAPD
                     FIAFKTRYKLIWGSIFSFLEQIEKFLKDYAISEAKVRGKSLVSLLPEFELNNKLTKTD
                     VLAVLENPLHIQMLLNLPGQRFKGRDGRTEAAVKIQATWKSYKARTSFISYRQKKWAS
                     GVIALAWLLHCHKTRLKRIVEESRQRHLDNFRIRAKHLAANWSRIRTSRRTIIHIPSL
                     DVNVNVIYVCSSPMNDELKLYYKKLLSLQAAVKSGYYGDRSDLQNRFRIITPEAVNIF
                     TKHHMCLATHLMYSPKAIKRIKNLIQGEEAYIVGGILHRDDLAVADMLNVPILASEPE
                     LVHLYSGKSGSKRIFDNANVPMPPGVYDIYTYQQLIEQLSQLVTDNLGIRRWVFKMNM
                     EFGGNGTAFCDIPSHLQCYKWVVKESNRFGPEDWKKKWAQESALMKISEELAGVLAQH
                     VQLVNEKQFPTWRKFLHMFLTQGGIIEAYPPADSITNLTVDMLIEPDGEVRVLSMGDQ
                     FHADGPFISSGTTMPQTSVDPQVLNSLCLRIGNICKEKDVVGYFSIDLVTFIDPSTLE
                     QQVWTTGLNLSYSDQLAMTQLTLYLTNGYLNCSLSTLEVPRFKEDAEREKKRLSIQAE
                     LAPETSRYAVMSTQLKHDNLSLIFYYVFLQMCKAHGIGYDLEDRQGTVFILYESLKRY
                     KLGMITIGVDLQGALMTFARNLFIIHQEISAPDMQGETNFKTTIDDIETILGVTEENK
                     MIFAGEKRRKEEEESLYEPVEIYTKTV"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     exon            117..239
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            329..443
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            682..810
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            811..932
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            933..971
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1523
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1766
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..2039
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2231
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2352
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2639
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2810
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2933
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..2995
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3104
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3627
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctagaa gcgctccgga gaaggccata cctccggagc caagcgcctt ctgcctgcct
       61 cagtcatggc tcaggcccag gagctcaacg accccattgg atccatccta atccaggtcc
      121 atggggacct ccatcagtta aaggagaaat taattcaatt ctcagctgag gagacaagag
      181 accctctaga cattcaaaat cttgagacag caattcaaag aactgaaacg gggttaaaga
      241 ttcacattga gaggtatctc ggaattgtaa accaggaggt gataatgact cctgtgaaga
      301 gcttagactc ccctatcaat tccaaatggg cgattccaac tgtaattgac cagaaatcct
      361 ttatttttcc catggctccc gataaacttt ggggacttca aaaacatcgc ggttcacttc
      421 cacgcggctt tacaagagca aagccaaaag tagagttgaa caagaagatc atgcaggacc
      481 ctgagaacat gcaccacaga gctgctgtaa atgtgagcta tgggatcagt ttgccacgta
      541 ttaaacagag gaaagcacat gataaggttc ggcgggtaag aaaagggtcc acgatctcca
      601 acctcacagt tctgccatcc agtcatcgca ctgaccccca ttttatcccc atacctgtct
      661 tgcaaaagga tgccagtaaa gggatcttaa gtatgatcga acgagggctg atccccccag
      721 cagcaaggat tacctttcag aatccaccca ttaaacccca agcacttcct ctgcatagct
      781 ttgatgagca tcggaaggta tcaataacag cctcctttcc gatagctcat aagccacgcc
      841 tggcttcaga aaaagtggag gagtctcaac agaaacagaa agccaaggta ctcacacatc
      901 taagcacgga agaacacagt ctacctgtga cgggaaaaga caaaaggtca agaggacaac
      961 ccagtaggaa gagcacgagg attactacac cgtctaggat taggagatca ccatgggatt
     1021 acatcttgcc tgtttacaac ggctctgtag acagggcagc cccagacttt atagcattca
     1081 aaacacgtta caaattaatc tggggaagca ttttttcttt cctggaacaa attgagaaat
     1141 ttctcaagga ctatgcaata tcagaagcca aagtaagagg gaagagtctg gtgtccctgc
     1201 ttccagagtt tgagctgaac aacaaactta ccaaaactga cgttctggct gtgctagaga
     1261 acccgctcca catccagatg ctgctaaatc ttcctggaca gaggttcaag ggccgggacg
     1321 gaaggacaga ggctgccgtc aagatccaag ccacatggaa aagttataag gcaagaactt
     1381 ccttcatttc ttatcgccag aagaagtggg cctcgggagt gatcgccctg gcatggcttc
     1441 tacattgcca caaaacaaga ctaaagagga tagtggagga atctcgacag agacacctgg
     1501 ataacttccg aattcgagcc aagcatctgg cagccaactg gagtcgcatc aggacctcca
     1561 ggaggactat tatccatata ccatcattag atgtcaacgt caatgtcatc tacgtctgct
     1621 ccagtcccat gaatgacgag ttaaagctgt actacaaaaa actcctgagt ctgcaagcag
     1681 ctgtcaaatc gggctactat ggggataggt ctgacctgca aaacaggttc agaattatca
     1741 cccctgaagc tgtaaacatc ttcactaaac atcacatgtg cctggctact cacctgatgt
     1801 acagtcccaa ggcaatcaaa agaataaaaa atctcatcca aggagaagag gcctacatcg
     1861 tgggcgggat cctccacaga gatgatttag ctgtggctga catgttgaat gtacccatcc
     1921 tggcctcaga gcctgagctg gttcaccttt acagtggcaa gtctggaagt aaacggatct
     1981 ttgataacgc taatgtgcca atgcctcctg gagtatatga catctatact taccagcagc
     2041 tgatagaaca attgagtcag ttggtgactg ataacctggg aatccgacgc tgggtcttta
     2101 aaatgaacat ggaatttgga ggaaatggga cagcattttg cgacatccct tcccatctac
     2161 agtgctacaa atgggtggtg aaggagagta acagattcgg ccctgaggac tggaagaaga
     2221 agtgggcaca agagtcagct ctgatgaaga tctccgagga gctggcgggc gttttagcac
     2281 agcacgtaca gctagtcaat gagaaacagt tcccgacatg gagaaaattc ctccacatgt
     2341 ttctcactca aggtggcatc attgaagcat acccacctgc agacagcatc accaacctca
     2401 ccgtagacat gttgatagag cctgacggag aagtcagagt gctgtcaatg ggggaccagt
     2461 ttcatgctga tggccccttt atttcttctg gtaccaccat gcctcagact tcagtggatc
     2521 cccaagttct caattctttg tgcctccgaa ttggaaatat ctgcaaagag aaagatgtgg
     2581 ttggttattt ttctatagat ctggtgactt ttattgatcc aagcacctta gagcagcagg
     2641 tatggacaac aggcctcaac ctctcataca gtgaccagct agccatgacg cagctcaccc
     2701 tgtacctgac aaatggttat ctgaattgta gtctgagcac cctggaagtg ccccgtttta
     2761 aagaagatgc agaaagggaa aagaaacgtc tgagcatcca ggcagagctg gccccagaaa
     2821 ccagtcgcta tgcagtgatg tccacacagc tgaagcacga caatctctca ctcatcttct
     2881 attatgtttt tctccagatg tgtaaggccc atggcatcgg ctatgacctt gaggacagac
     2941 aaggaactgt ttttatatta tatgaatctc tgaagagata caagttgggc atgataacaa
     3001 tcggtgtgga tctccagggg gccctcatga cctttgctcg caatctcttc atcatccatc
     3061 aagaaatatc agcacctgat atgcaaggcg agaccaattt taagactacc attgatgata
     3121 ttgaaaccat tttaggagta acagaagaaa ataaaatgat atttgcagga gaaaaacggc
     3181 gcaaagagga ggaagagagc ctgtatgagc ctgttgagat atacacaaaa acagtatgac
     3241 tttggatacc tgtctaaagc gagaaaaaag gtttgctttg taattaatgt aaaagtgagg
     3301 aagttagttt gctttgtttg ccaagagata aatcagaaca aattgtaaca taatagtctt
     3361 taaaatcttt gcttattttc cagtgttatt ttactcatta aggttaaacc taccggtgtt
     3421 ttcattgtga gtgctaagaa tcccttcctc ctccccaaaa caaagaagcc agaggaaggc
     3481 tttggcccac tactgctcca cttcttttct cctgcttcca aaagccactt agggtcttca
     3541 tttaaaatac caaataaacc agagtgatca cttgtcaaaa cacaaatgtc ctcttttccc
     3601 aaaataaatg aaatcagttt taaatga
//
LOCUS       NM_001436498            5434 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 8, mRNA.
ACCESSION   NM_001436498 XM_063265390
VERSION     NM_001436498.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5434)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5434)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265390.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1703310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000008.1  38090295-38090648
            355-527             JAXUCZ010000008.1  38092744-38092916
            528-729             JAXUCZ010000008.1  38095209-38095410
            730-857             JAXUCZ010000008.1  38098165-38098292
            858-1032            JAXUCZ010000008.1  38099310-38099484
            1033-1134           JAXUCZ010000008.1  38100022-38100123
            1135-1208           JAXUCZ010000008.1  38100738-38100811
            1209-1293           JAXUCZ010000008.1  38101595-38101679
            1294-1474           JAXUCZ010000008.1  38102404-38102584
            1475-1583           JAXUCZ010000008.1  38103121-38103229
            1584-1710           JAXUCZ010000008.1  38103788-38103914
            1711-1776           JAXUCZ010000008.1  38104177-38104242
            1777-1856           JAXUCZ010000008.1  38105285-38105364
            1857-1903           JAXUCZ010000008.1  38105453-38105499
            1904-1961           JAXUCZ010000008.1  38106236-38106293
            1962-2136           JAXUCZ010000008.1  38106533-38106707
            2137-2243           JAXUCZ010000008.1  38108447-38108553
            2244-2367           JAXUCZ010000008.1  38110471-38110594
            2368-2447           JAXUCZ010000008.1  38111060-38111139
            2448-2662           JAXUCZ010000008.1  38111280-38111494
            2663-2933           JAXUCZ010000008.1  38111574-38111844
            2934-3146           JAXUCZ010000008.1  38112380-38112592
            3147-3914           JAXUCZ010000008.1  38114925-38115692
            3915-4021           JAXUCZ010000008.1  38118990-38119096
            4022-4157           JAXUCZ010000008.1  38119994-38120129
            4158-5434           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5434
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..354
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            355..527
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             393..4283
                     /gene="Nfrkb"
                     /note="isoform 4 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 4"
                     /protein_id="NP_001423427.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSW
                     LPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKHHEKRKHQPDHPD
                     LLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKLIKSEAEDLA
                     EPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQ
                     ASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVE
                     FKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDAMTPVPRVTDYV
                     VRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHS
                     LLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSG
                     ALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPP
                     SKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPALPTPISPPPVSAV
                     SRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQTTARVVSHSSSAG
                     LPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKVVPQAVVATVPVK
                     GQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSASTTAVIQNVTGQN
                     IIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPD
                     MMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVPS
                     SAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVASSEAKPAATIRIV
                     QGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINATVSKTVAVASGAT
                     STPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMKGKSVVTAPIIK
                     GNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVP
                     ASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    516..851
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(537..539,561..563,573..575,585..587,597..599,
                     609..617,621..623,642..644,654..656,666..668,681..692,
                     699..704,711..713,723..725,762..764,774..776,783..788,
                     795..797,807..809,816..821,837..842,849..851)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1566..1826
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1566..1826
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2436..3050
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2436..3050
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3333..>3953
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <3333..>3953
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            528..729
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            730..857
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1032
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1134
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1208
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1293
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1474
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1583
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1710
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1776
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1856
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1903
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1961
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2136
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2243
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2367
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2447
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2662
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2933
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3146
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3914
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4021
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4022..4157
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..5434
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggtgggg ctggagacgt ggggctacgg ccggagagcc ttgctcgcag cttgctcggg
       61 agggtctgga gggtgggcta gccccaggtg cagagaagag gccttcctgg tctagcgagg
      121 aagtcccgga caccccaaca cttagaaatc tgcagcttcc ggggtttcag ctcgctggta
      181 gcgccggtgt tttcgtattt tgagagagta agtggcaaga cagaggttgt cactagatat
      241 taacgtttag cttaaccaac cgtcggcact ggaagaagct tctgagcgag ttgtgtacat
      301 tatgcacctg tcagatgagg taactgactt tgcacgctgc ctatgccacg tacgggtgta
      361 tttttaggta gtgtacctgt ggagaagaaa caatggattc cttggatcac atgctgacag
      421 atcccctaga acttggtcct tgtggagatg gtcacagtac agggatcatg gaggactgcc
      481 ttctgggtgg aaccagggtt agtctgcctg aagacctgct ggaggatcct gaaatattct
      541 ttgacgtcgt cagcctctcc acatggcagg aagtactaag tgactctcag cgtgaacatc
      601 tccagcagtt tctgccgcag tttcctacag acactgtaga gcagcagaat gagctcatcc
      661 ttgccctatt cagtggggag aacttccgct tcggaaaccc tctgcacatc gcccagaagc
      721 tcttccgaga tggacacttt aaccctgagg tggtcaagta tcggcagctc tgcttcaagt
      781 cacagtacaa gcggtacctc agctcccaac agcagtattt ccaccggctg ctgagacaga
      841 ttcttgcttc cagaagtgat ctcctggaga tggctcgcac gagcggcccg gctcttccct
      901 ttcgacacaa gcaccattca ccatcccgaa gcccggagga gcgggagtgg cggacccagc
      961 agcgttacct gaaagtcttg agggaagtga aggaggagtg tggcgacact gccctgtcgt
     1021 ctgatgagga ggatctcagc tcatggcttc caagctctcc agcacgctct cctagtcctg
     1081 cggtgcccct gagggtggtg cccacgcttt ccaccacgga tatgaaaact gcagataaaa
     1141 tagaactggg ggacagtgac ctgaagttaa tgttaaagaa acaccatgag aagcggaaac
     1201 atcaaccaga tcacccagac cttttgacag gggatctgac tctcagcgac atcatgactc
     1261 gagtaaatgc cggcaggaag ggctctctag cagccttgta tgatttggct gttcttaaaa
     1321 aaaaggtgaa ggaaaaggag gagaagaaaa agaagaaaat aaagttgatt aaatcggagg
     1381 cagaggatct ggctgagccc ctaagcaata ctgaaggggt cccaacgctc tcccaggccc
     1441 cctctcccct ggcaatatcg tctatcaagg aagaacccct ggaagacatc aagccttgtc
     1501 ttggaatcaa tgaaatatct tccagttttt tctctcttct gttagagatc ttgctgctgg
     1561 agagtcaggc tagccttcct atgctggagg accgggtttt ggattggcag tcttctccag
     1621 ccagctccct caacagctgg ttctctgctg cccccaactg ggctgagttg gtgttgcctg
     1681 ctctgcagta tcttgctgga gaaagccgag cagttccttc cagtttttct ccatttgttg
     1741 aattcaaaga gaaaacccag cagtggaaat tgcttggtca atctcaagat aatgaaaagg
     1801 aattagccgc tctcttccac ttgtggctag aaaccaaaga ccaggctttc tgtaagcagg
     1861 aaaatgaaga cagctcagat gccatgacac ctgtgcctcg agtaactgac tatgtggttc
     1921 ggcctagcac aggagaggag aaacgggttt ttcaagagca ggagcgttac aggtatagcc
     1981 aaccccataa ggcattcacc tttcgcatgc atggctttga gtctgtggtg gggccagtga
     2041 agggcgtgtt tgacaaggag acctccctca acaaggctcg tgagcactca ctgctgcgct
     2101 ctgaccggcc tgcctatgtc accattctgt ctcttgttcg ggatgctgcg gctcggctgc
     2161 ctaatggaga aggcactcgg gcagagatct gtgagctgct caaggactct cagtttcttg
     2221 ctcctgatgt caccagcact caggtgaaca cggtagtgag tggcgcactg gatcgattgc
     2281 attatgagaa ggacccttgt gtgaaatacg acattggtcg gaagctgtgg atctacctgc
     2341 atcgtgaccg gagtgaggaa gagtttgaac ggatccatca agctcaagca gcagcagcta
     2401 aagccagaaa agctcttcag caaaaaccca aaccgccatc caaggtgaag tccagtaata
     2461 aggagggctc cgtgaagggc cttagtggtc cttctgagcc cagccagatg agcctcagtg
     2521 actccagcat gccacctacc ccagttacgc ctgtaacccc caccacgcca gcattgccta
     2581 cccctatctc tcctccacct gtgtcagcgg tgagcagaag tggctctacc actgtctctg
     2641 agccagccaa gtctagttca ggtgttcttc tggtgtcctc accaacaatg ccacagctag
     2701 gaacgatgct ttcccctgct tccatccaga ctccgcccag ttctcagacc actgctcggg
     2761 ttgtcagcca ttccagctca gcaggactgc cccaggttcg ggtagtagcc cagcccagcc
     2821 ttcctgctgt ttcccagcag tcagtagggc cagcacagcc actaccccag atgccagcag
     2881 gaccacagat ccgtgtgcca gtcaccgcta cccaaaccaa agtagtaccc caggcagttg
     2941 tggctacagt tccagtcaag gggcagacta cagcggcctc tgtgcaacgg cctggacctg
     3001 cacagacagg acttacagtg acgagtcttc ctgctgcagt tagccccggg agcaagacag
     3061 ccatgagttc tcctgggagc tctgctccaa gtgcctccac aaccgccgtc attcagaatg
     3121 tcacaggaca gaacatcatc aagcaggtgt caatcactgg acagcttggt gtgaagcccc
     3181 agacaggcaa cagcattcca ctcacagcca caaacttccg tatccagggt aaagatgtac
     3241 tgcgcctgcc gccttcttcc atcaccacag atgccaaggg ccagacggtt ctgagaatca
     3301 ctccagacat gatggccaca ctggccaagt ctcaggtcac cacagtcaag ttgactcagg
     3361 acctctttgg ggcaggtagc ggcactgcag gcaaaggcat ctctgctacc ttgcatgtga
     3421 cttccaaccc tgtccatgcg gctgacagcc ctgccaaggc cccttcagcc agtgttcctt
     3481 catcagctcc agcgggcact accgtggtca aagtaactcc tgatctcaag ccaacagaaa
     3541 cctccagttc agcttttcgc ttgatgccag ctcttggcgt gagtgtggca gatcagaagg
     3601 ggaagaacac agtggcctct tcagaagcaa aacctgctgc cacaatccgc attgtgcagg
     3661 ggctgggagt gatgcctcct aaagcaggcc agaccattac tgttgcagca catgcaaagc
     3721 aaggagcctc tgttgctggt gggtctggaa ctgtccattc ttcaactgtg tccttaccca
     3781 gtatcaatgc cactgtgtct aagactgtgg ctgtggcttc tggagcaaca agcaccccca
     3841 tcagcatcgg gactggagcc cccaccgtgc gacaggttcc tgttaacact acagttgtgt
     3901 ccacatccca gtctgggaag ctgcctacca ggatcacagt tcctctctct gtgattagcc
     3961 agccaatgaa gggcaagagc gtggtcacag cccccatcat caaaggcaac cttggagcca
     4021 atctcagtgg gctgggtcgc aacatcatcc tcacaaccat gccagcgggt gctaagctca
     4081 ttgctggcaa taagccagtg agtttcctca ccgcccagca gttgcagcag cttcagcagc
     4141 aaggtcaggc tacacaggta cgcatccaga ctgtgccagc atcccatctg caacagggca
     4201 cagcttccgg ctcctccaaa gccgtgtcca ctgttgttgt gaccacagct ccatctccta
     4261 aacaagcacc tgagcagcag tgactgagaa gaaaggcggc ttctttaaga gaccaggcct
     4321 ggtttatctc ggctgacaga aagggagcag ggaggctgca ccattcttct gagctgtcct
     4381 gcttgaggca gggtggtgga gagtgatggc aactgtggcc tagattgtgc tgccacactc
     4441 cagagtgaag ccctttttag ggttccaggg atgatctgtt atcctggact accaggaaga
     4501 gggaaggaac atcagagtct ggggaggtca cagtcacaca agccggggtt acctcctgaa
     4561 tgttgggttc ccagggagca ggcctgccag ttggtgagtg gaccggcagg gaataagcct
     4621 cattctgtgt gaggatttta ctttttagtt tctgatcttc tccgtgactt gttgagatgt
     4681 gagttttgtg tccagagaat ttttgtgtaa cttatttttt taaagaacct actctacgtc
     4741 ttttatcaaa tagaaacctg ggcttcagtg cccctaaact gatcacttac cccttcaacc
     4801 agaatgagag catagcaaga ctcttaatag tttggcggct tacttgataa tggagaggtt
     4861 atatagtaag aaaatgtagg ccttgagtta gcatggaccc cctcaagtgg gactagttca
     4921 atgccgtgta ctaaatatgg gcatctgaat ctcggttgtc cctatgtctt ctcttgtggg
     4981 cattgtcctt gacaagcctg ttcatggaag ttcagagctt ttggacagga gtaggggaag
     5041 atgaggtgct gctctcaccg tgcacttgct tacagcccag acattgcaca ttctccttgc
     5101 tgtagaacag ccattgctaa ccagaccctt ggagctggcc acttgactgg gacagagaag
     5161 aaatggggag gtgggggcag gggtaggcac tgcctggcag tgccatcttg aggggaaagg
     5221 atgtttttat tctggccatt tcatatttct cagccaccac cagccacaga cagggctcag
     5281 aagggtactt tacaaagtcc aagtacttaa tgtactaggt gtatcttaac gtgtcttgct
     5341 gtggtgcagg ggtgggtagg aaaacctttc tgcagggata gtgcttccct gtctctttgt
     5401 gaaaatatcc aaattattaa aaacatatct ttaa
//
LOCUS       NM_001436484            3285 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436484 XM_006243749
VERSION     NM_001436484.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243749.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1769952.1,
                                           SRR26643292.35543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000008.1  118095438-118095587
            151-480             JAXUCZ010000008.1  118106884-118107213
            481-1512            JAXUCZ010000008.1  118112261-118113292
            1513-1690           JAXUCZ010000008.1  118120474-118120651
            1691-1845           JAXUCZ010000008.1  118121209-118121363
            1846-1960           JAXUCZ010000008.1  118122735-118122849
            1961-2069           JAXUCZ010000008.1  118131517-118131625
            2070-2221           JAXUCZ010000008.1  118131953-118132104
            2222-2312           JAXUCZ010000008.1  118132470-118132560
            2313-3285           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3285
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..150
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            151..480
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             172..2505
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423413.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <187..315
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <187..315
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    1969..2451
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    1969..2451
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            481..1512
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1690
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1845
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1960
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2069
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2221
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2312
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..3285
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatgtaaga tggcgcccag ggagctgtga ggagaaaatc ctgtcggtct tggagcagcg
       61 gtggcagaac cgaggcccca ggcggtgaag cggggccgga gggtagagtg gaggcagcgg
      121 cggcggtgac gtcgccgggt gagggctctg gaaccctaag gactctgcaa tatgaataat
      181 tctctagaga acaccatctc atttgaagag tacatccgag taaaggcgag gtctgtcccg
      241 caacacagga tgaaggaatt tctggactcg ctggcttcta agggaccaga agctcttcag
      301 gagttccagc agtctgccac caccaccatg gtgtaccagc agggtgggaa ctgcatttat
      361 acagacagca ctgaagtggc tgggtctttg cttgaacttg cttgtccagt cacaaccagt
      421 gttcaaccac aaactcagca agagcagcag atccaggttc agcagccaca gcaggttcag
      481 gtacaggtgc aggtacagca gtctccacag caggtctcag ctcagcagct ttccccgcag
      541 ttcaccgttc accagcctgc tgagcaaccc atccaggtcc aggtgcagat ccagggccaa
      601 gcaccacagt ccgcagcccc ctccatccag actccatcac tgcagagccc cagcccctcg
      661 cagctgcaag cagcccagat ccaggtgcag cacgtgcagg cagcgcagca gatccaggct
      721 gcagaaatcc cagaggagca tatcccacat caacagatcc aagctcagtt ggtggcaggc
      781 caatctcttg ctgggggcca gcagattcaa attcagaccg tgggcgctct ttccccacca
      841 ccctcccagc agggctcacc cagggaaggg gagcggaggg ttggcacagc cagtgtcctt
      901 caaccagtga agaaacgcaa agtggacatg cccatcaccg tgtcctatgc catctcaggg
      961 cagccagtgg ccaccgtgct ggccattcca caaggccagc aacagagtta cgtgtctttg
     1021 aggccagact tactgacagt agacagtgcc cacctgtaca gcgccactgg gaccataact
     1081 agccctacag gagaaacttg gaccatccct gtttattccg cccagccccg gggggaccct
     1141 cagcagcaga gcattaccca cattgccatt ccccaggaag cctacaatgc agttcacgtc
     1201 agtggctcac ccacggctct ggcagctgta aagctggagg atgacaagga gaagatggtg
     1261 ggcaccacat ccgtagtgaa gaactcccat gaagaggtag tgcagaccct tgcaaactct
     1321 ctctttccag cacagttcat gaatggcaac atccacattc cagtggctgt gcaggctgta
     1381 gcaggcacgt accagaatac ggctcagact gtacatatat gggacccaca gcagcagccg
     1441 caacagcaaa ctgcacaaga acagacacca ccacagccac agcaacagca gcagctgcag
     1501 gtcacttgtt cagcacaaac tgttcaggtc gctgaagttg agccacagtc acaaccgcag
     1561 ccttcaccag agcttttgct tccaaattca ctgaagccag aagaagggct agaagtatgg
     1621 aaaaactggg ctcagaccaa gaatgctgaa ctagaaaagg atgctcaaaa cagattggcc
     1681 cccattggga ggcgccagtt gctacgattc caagaagatc tgatctcatc tgctgtggct
     1741 gaattgaatt atggcctttg tttaatgaca cgagaagctc ggaatggaga aggtgaaccc
     1801 tatgacccag atgtactcta ctacattttc ttgtgtatac agaagtatct ttttgaaaat
     1861 ggaagagtag atgacatatt ctctgatctt tactatgttc gttttaccga atggctacat
     1921 gaagttctga aggacgtgca gccccgggtc actccacttg gctatgttct gcccagccac
     1981 gtgactgaag agatgctgtg ggaatgcaag cagcttgggg cacattcccc ttcgacactg
     2041 ctgaccaccc tcatgttctt caacaccaag tactttctgt tgaagacagt agatcagcac
     2101 atgaagctgg cgttctccaa ggtcctccgg cagacaaaga agagcccctc gaatcctaag
     2161 gataaaagca ctagtatccg ctacctgaag gccctcggaa tacatcagac tggccagaaa
     2221 gttacagatg acatgtatgc agaacagaca gaaaatccag agaacccatt aaggtgtccc
     2281 atcaagctct acgatttcta cctcttcaaa tgcccccaga gtgtgaaagg ccgaaatgac
     2341 accttttacc tgactcctga gcctgttgtg gctcccaaca gcccgatctg gtactcagtc
     2401 cagcctatca gccgagagca gatgggacag atgctgaccc ggatcctggt tatacgagag
     2461 attcaagaag ccattgccgt ggccaacgca accaccatgc actgaggtgc ctcagccaca
     2521 ggaaaaaaaa aaatccagga aaaaccagac agacttttac actaaaggag aggcctccat
     2581 ttttttcttt ttctttttcc ttcaattcgt agttctaatg cttttcaggc gacttctgtt
     2641 aaaaatgtaa aagacaatgt tgccctcttt gcatcttcat aaaatgggca gaccccctgg
     2701 ttcatgggta tatggttttc ctagaacttg atgtcctagg aagtggttgg cttttacctt
     2761 tcttttcctt ttttttcttt tgtctgggct ggagtgtggg ggaagggact tggactgtat
     2821 ggagaaatat aggcccttcc cttcctcaag gcagatggag cagccgatga atcaaccctc
     2881 ctgcaaaccc ccacctttca ctctggaccg gcaggcttaa ccactcggag ccacgatttt
     2941 tctttttttt tttttttttt ttttttttaa atgctcagac ataaacttag catcttgatg
     3001 gaataaaaat gaggggaact tcaattatga tttttattaa agacaatttc tattacaccc
     3061 ttctttatga caagtgacat agatgttaaa gtaaaaactt taccatgctt tttttttttt
     3121 tttttttttt ttttggccta acattgaggc cttaaacctg aggctcctgt gcctgatgga
     3181 attcttgtaa catacacttg tgtatcatat aaagatacca ctctttctct tatgtattct
     3241 tattctagtt gtttattaag aatgacaagc acgtcttttc aacaa
//
LOCUS       NM_001044225            2106 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus TATA-box binding protein associated factor 6
            (Taf6), transcript variant 2, mRNA.
ACCESSION   NM_001044225 XM_001056390 XM_001066592 XM_001066806 XM_213729
VERSION     NM_001044225.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984. PMID: 27096372]
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Malkowska,M., Kokoszynska,K., Rychlewski,L. and Wyrwicz,L.
  TITLE     Structural bioinformatics of the general transcription factor TFIID
  JOURNAL   Biochimie 95 (4), 680-691 (2013)
   PUBMED   23146842
  REMARK    Review article
REFERENCE   3  (bases 1 to 2106)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   4  (bases 1 to 2106)
  AUTHORS   Wilhelm,E., Kornete,M., Targat,B., Vigneault-Edwards,J.,
            Frontini,M., Tora,L., Benecke,A. and Bell,B.
  TITLE     TAF6delta orchestrates an apoptotic transcriptome profile and
            interacts functionally with p53
  JOURNAL   BMC Mol Biol 11, 10 (2010)
   PUBMED   20096117
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2106)
  AUTHORS   Tatarakis,A., Margaritis,T., Martinez-Jimenez,C.P., Kouskouti,A.,
            Mohan,W.S. 2nd, Haroniti,A., Kafetzopoulos,D., Tora,L. and
            Talianidis,I.
  TITLE     Dominant and redundant functions of TFIID involved in the
            regulation of hepatic genes
  JOURNAL   Mol Cell 31 (4), 531-543 (2008)
   PUBMED   18722179
REFERENCE   6  (bases 1 to 2106)
  AUTHORS   Pointud,J.C., Mengus,G., Brancorsini,S., Monaco,L., Parvinen,M.,
            Sassone-Corsi,P. and Davidson,I.
  TITLE     The intracellular localisation of TAF7L, a paralogue of
            transcription factor TFIID subunit TAF7, is developmentally
            regulated during male germ-cell differentiation
  JOURNAL   J Cell Sci 116 (Pt 9), 1847-1858 (2003)
   PUBMED   12665565
REFERENCE   7  (bases 1 to 2106)
  AUTHORS   Bell,B., Scheer,E. and Tora,L.
  TITLE     Identification of hTAF(II)80 delta links apoptotic signaling
            pathways to transcription factor TFIID function
  JOURNAL   Mol Cell 8 (3), 591-600 (2001)
   PUBMED   11583621
REFERENCE   8  (bases 1 to 2106)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
REFERENCE   9  (bases 1 to 2106)
  AUTHORS   Kida,S., Umehara,T. and Horikoshi,M.
  TITLE     Three distinct regions in a rat TFIID subunit containing histone H4
            homology
  JOURNAL   Gene 161 (2), 303-304 (1995)
   PUBMED   7665101
REFERENCE   10 (bases 1 to 2106)
  AUTHORS   Weinzierl,R.O., Ruppert,S., Dynlacht,B.D., Tanese,N. and Tjian,R.
  TITLE     Cloning and expression of Drosophila TAFII60 and human TAFII70
            reveal conserved interactions with other subunits of TFIID
  JOURNAL   EMBO J 12 (13), 5303-5309 (1993)
   PUBMED   8262073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001044225.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100108.1, SRR26643287.27867.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000012.1  22177903-22177949   c
            48-263              JAXUCZ010000012.1  22175128-22175343   c
            264-350             JAXUCZ010000012.1  22174655-22174741   c
            351-504             JAXUCZ010000012.1  22174403-22174556   c
            505-561             JAXUCZ010000012.1  22174177-22174233   c
            562-681             JAXUCZ010000012.1  22173936-22174055   c
            682-827             JAXUCZ010000012.1  22173518-22173663   c
            828-905             JAXUCZ010000012.1  22173329-22173406   c
            906-1007            JAXUCZ010000012.1  22173115-22173216   c
            1008-1190           JAXUCZ010000012.1  22172823-22173005   c
            1191-1265           JAXUCZ010000012.1  22172035-22172109   c
            1266-1391           JAXUCZ010000012.1  22171810-22171935   c
            1392-1565           JAXUCZ010000012.1  22170679-22170852   c
            1566-1763           JAXUCZ010000012.1  22170358-22170555   c
            1764-2106           JAXUCZ010000012.1  22169570-22169912   c
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2106
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="TATA-box binding protein associated factor 6"
                     /db_xref="GeneID:288533"
                     /db_xref="RGD:1311608"
     exon            1..47
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            48..263
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="upstream in-frame stop codon"
     CDS             108..2051
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="isoform 2 is encoded by transcript variant 2; TAF6
                     RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80 kDa; transcription initiation
                     factor TFIID subunit 6; TFIID subunit p80; TAFII80;
                     TAFII-70; TAFII-80; TAF(II)70; transcription initiation
                     factor TFIID 70 kDa subunit; transcription initiation
                     factor TFIID 80 kDa subunit"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 6
                     isoform 2"
                     /protein_id="NP_001037690.1"
                     /db_xref="GeneID:288533"
                     /db_xref="RGD:1311608"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVS
                     YRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGR
                     ELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAE
                     ATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSV
                     EQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNL
                     ALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAA
                     RLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLI
                     LPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRG
                     EFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLK
                     VPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQGKAKEALLLILLQS
                     HLHLLHHLHLGAVPSVGGSRKLGTAPLQLQGLQRLMAPSLLDLALPSLLCDIVTCADL
                     LSSADSYTHKQRVREEEERCFPQ"
     misc_feature    132..1331
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Transcription initiation factor TFIID, subunit TAF6
                     (also component of histone acetyltransferase SAGA)
                     [Transcription]; Region: TAF6; COG5095"
                     /db_xref="CDD:227426"
     misc_feature    132..1331
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Transcription initiation factor TFIID, subunit TAF6
                     (also component of histone acetyltransferase SAGA)
                     [Transcription]; Region: TAF6; COG5095"
                     /db_xref="CDD:227426"
     misc_feature    465..467
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    531..710
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63801.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    747..1397
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="C-terminal domain of TATA Binding Protein (TBP)
                     Associated Factor 6 (TAF6); Region: TAF6C; cd08050"
                     /db_xref="CDD:381749"
     misc_feature    747..1397
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="C-terminal domain of TATA Binding Protein (TBP)
                     Associated Factor 6 (TAF6); Region: TAF6C; cd08050"
                     /db_xref="CDD:381749"
     misc_feature    order(759..767,771..776,783..785,816..821,828..830,
                     840..842,849..854,870..872)
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381749"
     misc_feature    order(759..767,771..776,783..785,816..821,828..830,
                     840..842,849..854,870..872)
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381749"
     misc_feature    759..854
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    759..854
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    849..851
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    864..866
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    873..980
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    873..980
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    897..899
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    1008..1139
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1008..1139
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1158..1256
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1158..1256
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1260..1394
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1260..1394
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1677..1679
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); methylation site"
     exon            264..350
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            351..504
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            505..561
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            562..681
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            682..827
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1007
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1190
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1265
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1391
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1565
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1763
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2106
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccaaga tggcgccgag cgccgggtga gcggcgcctt ggcagcggat ctccatctct
       61 ccaccctggg gtgacatcct tccagggaca ggagctggaa ctccagcatg gctgaggaga
      121 agaaactgaa actcagcaat accgtgttgc cctccgagtc tatgaaggtg gtggcagaat
      181 ccatgggcat tgctcagatt caggaggaga cttgccagct actgacagat gaggtcagct
      241 accgcatcaa ggagattgcc caggatgctt tgaagttcat gcacatgggg aaacgacaga
      301 agctcactac cagtgacatt gactatgcat tgaaattaaa gaatgtggag ccactatatg
      361 gcttccatgc tcaggagttc atccctttcc ggtttgcctc tggtgggggc cgggagctgt
      421 acttctatga agagaaggaa gtggacctga gtgatatcat caacacccct ctgcctcggg
      481 tgcctctgga tgtctgcctc aaagctcatt ggctgagcat tgaaggctgc cagccagcta
      541 taccagagaa tccaccccca gctcccaaag agcagcagaa ggccgaggcc acagaacccc
      601 tgaagtcagc aaagccaggc caagaagaag atggaccctt gaaaggcaaa ggtcaagggg
      661 cagctgcagc tgatggcaaa ggaaaagaga agaaggcacc tcccttgctg gaaggggccc
      721 ctttccgcct gaagccccgc agcatccatg agctgtccgt ggagcagcag ctgtactaca
      781 aggagatcac agaagcctgt gtgggatcct gtgaggccaa gagagcggaa gctctgcaga
      841 gcattgccac agatcctgga ctctatcaga tgttaccacg gtttagtacc ttcatctcag
      901 agggggtccg tgtgaatgtg gttcagaata acctggcctt gctcatctac ttgatgcgaa
      961 tggttaaggc cctgatggac aaccccacac tgtatcttga gaaatatgtg cacgagctga
     1021 ttcctgcagt aatgacctgc attgtgagca gacagctgtg cctgcggcca gatgtggaca
     1081 atcactgggc actccgggat tttgctgccc gtctagtggc ccagatctgt aagcatttca
     1141 gcacaaccac caacaacatc caatcccgaa tcaccaagac ctttaccaag agctgggtgg
     1201 atgagaagac tccatggaca actcgatatg gctccattgc aggcctggca gagctggggc
     1261 atgatgtgat taagacccta attctgccaa ggctgcagca ggaaggggag cggatccgaa
     1321 gtgtcttgga cggacctgtt ctgagcaaca tcgaccgtat cggagcagac catgttcaga
     1381 gccttctcct gaaacactgt gccccagtat tggcgaagct gcgccctcca cctgacaatc
     1441 aggatgccta ccggggagaa tttgggtccc ttgggcccct tctctgctcc catgtggtga
     1501 aggccagggc ccaggccgct cttcaagctc agcaggtcaa caggaccaca ctcaccatca
     1561 cacagcctcg gcccacactg accctctcac aggcccctca gccaggccct cgtacccctg
     1621 gcttattgaa ggtccctggc tctattgcct tgcctgtcca gacactggtg tctgcaagag
     1681 ctgctgcccc tcctcagcct tctcctcctc caacgaagtt tattgtaatg tcctcatctt
     1741 ccagtgcctc atcaacccag caggggaagg caaaggaggc cctccttctc atccttctcc
     1801 agtcccacct tcatcttctt caccatctcc acttgggggc agtgccctct gtggggggaa
     1861 gcaggaaact ggggacagcc cccctccagc tccagggact ccaaaggcta atggctccca
     1921 gcctactgga cctagctctc cccagcctgc tctgtgatat tgtcacatgt gctgacctcc
     1981 tctcttctgc agattcctac acacacaaac aacgtgtgag ggaggaagaa gaaagatgtt
     2041 ttccccagtg actttctttt tagattctgt acagtaagtt cctcagaata aaagttggat
     2101 ttgtaa
//
LOCUS       NM_001436471            4262 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 7,
            mRNA.
ACCESSION   NM_001436471 XM_063265180
VERSION     NM_001436471.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265180.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1006765.1,
                                           SRR26643297.29090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000008.1  84575422-84575555
            135-251             JAXUCZ010000008.1  84576190-84576306
            252-436             JAXUCZ010000008.1  84629460-84629644
            437-639             JAXUCZ010000008.1  84630342-84630544
            640-765             JAXUCZ010000008.1  84630809-84630934
            766-2578            JAXUCZ010000008.1  84632504-84634316
            2579-2692           JAXUCZ010000008.1  84636539-84636652
            2693-2772           JAXUCZ010000008.1  84638961-84639040
            2773-2881           JAXUCZ010000008.1  84640128-84640236
            2882-3040           JAXUCZ010000008.1  84641283-84641441
            3041-3109           JAXUCZ010000008.1  84645727-84645795
            3110-3306           JAXUCZ010000008.1  84647790-84647986
            3307-4262           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4262
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..134
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            135..251
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    161..163
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             236..3460
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 2 is encoded by transcript variant 7;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 2"
                     /protein_id="NP_001423400.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLRTTLKHSSVWRKHDFHS
                     LDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCLNIEAD
                     PGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTFCPTHL
                     TLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMFV
                     VVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRFQSSKS
                     GKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    2864..3037
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    2864..3037
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3281..3454
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3281..3454
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            252..436
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            437..639
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            640..765
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2578
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2692
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2772
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2881
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3040
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3109
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3306
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..4262
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatcgtttg gaaaacgaag cagaagccat tgagtcagcc gtgtgccggt
      181 tggaagaacc cacacctgtg ttttacagca ctttgggtgg aaattggatg ccaaaatgaa
      241 gccagaccga gatgccttgg atgagtattt tgaatatgat gcagaggagt tcttggtctc
      301 tttggccttg ctgataactg aaggccgaac ccctgagtgt tccgtgaaag gccgtgcaga
      361 gagtttccac tgccctccag cgcagtctcg tttcccaggc gcagccagac atgagtgcag
      421 cgacaagctg gcccagtgtc gccaagccag acgaaccaga tctgaggtca cgctgttgtg
      481 gaaaaataat cttccaatca tggtagaagt gatgcttctg ccagattgct gctacagtga
      541 cgagggccct agcacagagg ggacagatct gaatgaccct gccattaaac aagatgcact
      601 gttactggag aggtggatct tggagccagt tccccgacag aatggcgatc gcttcatcga
      661 agagaaggca cttctgctgg ctgtcagatc attcgtgttt ttttctcagt taagtgcttg
      721 gctgagtgtt tctcatggtg ctattccacg aaacattctt tacagaatca gtgctgctga
      781 tgtcgacctg cagtggagtt tttcacagac tccaactgag catgtgtttc ccgttcccaa
      841 tgtctctcac aacgtggcct tgaaagtcag cgttcagtcc ttacccagac aagctcatta
      901 tccagttttg acctgtagta tccatactaa tattggtctg tatgagaaga gaattcagga
      961 acaggagctt cgagcctgtc agcaccgtgg ccctggtgaa gtggagtacc gttgtcccag
     1021 cagctctcag agtctgtgca gcaagcacac atggaccatg gcacctgtga gtgccctgca
     1081 tgtcagaagt ggcatgcctc ctgagtacac tgcagccatt agaaatgtca ggctctgccc
     1141 aggcacaggt agcaagtctg acaatggaac acctcaagcc agcgtcctgg gcttcagtgg
     1201 cactggagaa gtgaggtccc aggaggcatc agtgagaact ttcaaatcac tctctgtgat
     1261 cgattccagt gtctccagct gtcagagctc ccggcagcca gtaggggagc ctaacccttt
     1321 aatcgactcc ctgattcagg atcgacaaga agtcattgcc aggattgctc agcacttgat
     1381 tcactgtgac cccagctcct ctcgcatgtc tgaactcccc tttaacaccc cagagtccac
     1441 ttcacttagc ccaaagcttc acccagtttc acaggagagt gggtattcga gaagatgcaa
     1501 agaagcattc tctgtctctt ttgggagtcc agagtttggc tccccaggag acagcaagga
     1561 ggggaaagtg aaagagaagc tggaaaccag gcaaggagaa acctgtgcct ctcacagtcc
     1621 ctaccctcgg cagcctgctg gggaggcaaa cccactgatt ggctctttgc ttctggagcg
     1681 gcaggatgtc atagccagga tcgcacagca cttggagcac atcgacccca cagctcacat
     1741 tccccggcct gcgttcagca agcacgactc caattccatt ccttctaaag tgttcaggag
     1801 ttcatttcat gacaaaacca tgttgaagaa ggacagagag aatgtctctg tttctgctac
     1861 tcatacagaa gtgtccttat tgggagacag aggtgatggg aaaagcccca aacctagtaa
     1921 atgtttccga tctttcaaaa acagtcctca agaaaagtct ctgaaacctg aagaaagcgc
     1981 tcagcatcag aaccatcctg atgacatcac ccacacagcc aggcaggagt tgctgaacaa
     2041 ggctgctggc ttactcactt cctctaactc gtccctctgc aatgaaagca gcttggcttt
     2101 gattggcaga ttggaaagta catcttgtaa attacaactt aggaagcaag aaatgagcca
     2161 tgaaactgag aaacagtgtt tgcattgcaa cagtattgac aaacagattt gcacaaataa
     2221 atgcacagag aaaataaaag atgagaatag cccgggctct ctcagtcatc tccagtgtga
     2281 tgagtcaaga ggtattgacc caaaaataaa agtgactatg ttggaaatgc ctgactattt
     2341 gaacaagtac aaaactaatt gttcaaataa agactccaaa agatcaaaga catgtgagca
     2401 aaacattcag cttggcacag aaaattatct cagtgaagat actgagggtt ccaaaagcac
     2461 aatatcagac caactaaaaa ctgagcagga ggaaaacaaa gattcagttg ccggaaaacc
     2521 tccaagtgta aagcactgtc tgtctacaag cgaaagactg aaaaatgcag acatgttgag
     2581 gactacactg aagcattcaa gtgtctggag gaaacacgat tttcattccc tggatgggac
     2641 atcaaccaga gcctttcatc ctcagacagg gctgcctctc ctctcaagcc cagttcctca
     2701 aagaaaaaca cagtcaggtt gctttgatct agacacgtca ctactgcatc tgagaagtct
     2761 atcctccaaa agctctcgac cgtgtctgaa cattgaagcg gacccaggtg ttcatgaaaa
     2821 gccttttttg agttcaagtg ctccaccaat cacaagtctt agtctcctag ggaattttga
     2881 ggaatcggtt ctgaattacc gtttagaccc cctcggcata gttgatggct tcactgctga
     2941 ggtgggagcc agtgggactt tctgccctac gcacttgact ctgccggtgg aagtgtcgtt
     3001 ctacagtgtt tcggatgata acgctccctc gccttatatg ggtgtgatta ctttagagtc
     3061 ccttggtaaa aggggttatc gagtacctcc ttcaggaacg atacaagtga ccttattcaa
     3121 tcccaataag actgtggtga agatgtttgt tgtcgtgtat gacctacgaa gtatgccagc
     3181 caatcaccag acattcctgc ggcagaggac gttttctgtt cctgttaaac aagaaatgaa
     3241 gagaagtatt aacaaagaga atgtccagca cacggcacag ttactacgct acctcataca
     3301 cctgaggttc cagagctcta aatctgggaa gatctacctc catagagatg tccggctcct
     3361 gttctctaga aagtccatgg aggttgatag cggtgctgct tatgaactca agtcttacac
     3421 cgaatcgcca acaaacccac agttttcacc aagatgctga taagggagac ggattaaaag
     3481 tatttgctca gtacccaagc ttgaacgtga gcattcaccg agtggaatac atccaatgag
     3541 agccagtgga gtggagtggc cctcctcttg tcctggacca gattttatta aaggacccct
     3601 gaactgagac ccatgactcc taagtggact ggaagcaccc ctgtcttcac ccttttcgta
     3661 ctgttgaaac cacttcattg gacagttgca atagcaaaat ccccagttag attagtgttt
     3721 acacatttta tttctgttat ttaatattta atgttttcct taatagtcaa gtgatgtttg
     3781 tctctagtgt tctaatgtag cacaatctat gtaaaatcat actatgtatt tttgacatta
     3841 atgttgaaat tgaaatatat gcataagtct ttaattttgt gtggtgtgtt ttaagtgcta
     3901 ttcatttaag ctactgaaaa tgagaatgaa atgttgggct tctttaagat taatgcacta
     3961 tgcaagcatg tatgcttttg atatctctcc aggttaggtt ttaaagaact caccagggct
     4021 gttcccaggg gtccgacaaa gctgctccca tcctcctggc aaacactcag cctcctgccc
     4081 attctcatcc ttctaagatc ccccccaccc caaaaacatt ctattttccc tgaatcacta
     4141 ctgtagaggt tttactttaa attgctatcc catgctacat aattttctca cactgttaaa
     4201 aagaatatgt actttgaaaa gaatttaata tttatattgt aaatatatgc aaaaaactaa
     4261 aa
//
LOCUS       NM_001106838            4480 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 2,
            mRNA.
ACCESSION   NM_001106838 XM_001058484 XM_217194
VERSION     NM_001106838.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001106838.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.31158.1,
                                           SRR26643297.29085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JAXUCZ010000008.1  84575422-84575773
            353-469             JAXUCZ010000008.1  84576190-84576306
            470-654             JAXUCZ010000008.1  84629460-84629644
            655-857             JAXUCZ010000008.1  84630342-84630544
            858-983             JAXUCZ010000008.1  84630809-84630934
            984-2796            JAXUCZ010000008.1  84632504-84634316
            2797-2910           JAXUCZ010000008.1  84636539-84636652
            2911-2990           JAXUCZ010000008.1  84638961-84639040
            2991-3099           JAXUCZ010000008.1  84640128-84640236
            3100-3258           JAXUCZ010000008.1  84641283-84641441
            3259-3327           JAXUCZ010000008.1  84645727-84645795
            3328-3524           JAXUCZ010000008.1  84647790-84647986
            3525-4480           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4480
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..352
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            353..469
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    379..381
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             454..3678
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 2 is encoded by transcript variant 2;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 2"
                     /protein_id="NP_001100308.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLRTTLKHSSVWRKHDFHS
                     LDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCLNIEAD
                     PGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTFCPTHL
                     TLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMFV
                     VVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRFQSSKS
                     GKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    3082..3255
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3082..3255
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3499..3672
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3499..3672
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            470..654
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            655..857
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            858..983
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            984..2796
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2910
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..2990
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3099
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3258
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3327
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3524
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..4480
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatgtgagc ggcccggcgg ccgcagagag cagtgccggg aggaggagcg
      181 aggggtcccg gagggcggcg agcgggcggg ctatgggagc cgttcccggg tgggcagaga
      241 cacgcgtggg tcggcgcggc tgaggacatg cccagactct gctgctgacc ggctccggct
      301 ggaacccggc tactgaagcc tcggcgaggt tagccagagg ggatcctcgc agcgtttgga
      361 aaacgaagca gaagccattg agtcagccgt gtgccggttg gaagaaccca cacctgtgtt
      421 ttacagcact ttgggtggaa attggatgcc aaaatgaagc cagaccgaga tgccttggat
      481 gagtattttg aatatgatgc agaggagttc ttggtctctt tggccttgct gataactgaa
      541 ggccgaaccc ctgagtgttc cgtgaaaggc cgtgcagaga gtttccactg ccctccagcg
      601 cagtctcgtt tcccaggcgc agccagacat gagtgcagcg acaagctggc ccagtgtcgc
      661 caagccagac gaaccagatc tgaggtcacg ctgttgtgga aaaataatct tccaatcatg
      721 gtagaagtga tgcttctgcc agattgctgc tacagtgacg agggccctag cacagagggg
      781 acagatctga atgaccctgc cattaaacaa gatgcactgt tactggagag gtggatcttg
      841 gagccagttc cccgacagaa tggcgatcgc ttcatcgaag agaaggcact tctgctggct
      901 gtcagatcat tcgtgttttt ttctcagtta agtgcttggc tgagtgtttc tcatggtgct
      961 attccacgaa acattcttta cagaatcagt gctgctgatg tcgacctgca gtggagtttt
     1021 tcacagactc caactgagca tgtgtttccc gttcccaatg tctctcacaa cgtggccttg
     1081 aaagtcagcg ttcagtcctt acccagacaa gctcattatc cagttttgac ctgtagtatc
     1141 catactaata ttggtctgta tgagaagaga attcaggaac aggagcttcg agcctgtcag
     1201 caccgtggcc ctggtgaagt ggagtaccgt tgtcccagca gctctcagag tctgtgcagc
     1261 aagcacacat ggaccatggc acctgtgagt gccctgcatg tcagaagtgg catgcctcct
     1321 gagtacactg cagccattag aaatgtcagg ctctgcccag gcacaggtag caagtctgac
     1381 aatggaacac ctcaagccag cgtcctgggc ttcagtggca ctggagaagt gaggtcccag
     1441 gaggcatcag tgagaacttt caaatcactc tctgtgatcg attccagtgt ctccagctgt
     1501 cagagctccc ggcagccagt aggggagcct aaccctttaa tcgactccct gattcaggat
     1561 cgacaagaag tcattgccag gattgctcag cacttgattc actgtgaccc cagctcctct
     1621 cgcatgtctg aactcccctt taacacccca gagtccactt cacttagccc aaagcttcac
     1681 ccagtttcac aggagagtgg gtattcgaga agatgcaaag aagcattctc tgtctctttt
     1741 gggagtccag agtttggctc cccaggagac agcaaggagg ggaaagtgaa agagaagctg
     1801 gaaaccaggc aaggagaaac ctgtgcctct cacagtccct accctcggca gcctgctggg
     1861 gaggcaaacc cactgattgg ctctttgctt ctggagcggc aggatgtcat agccaggatc
     1921 gcacagcact tggagcacat cgaccccaca gctcacattc cccggcctgc gttcagcaag
     1981 cacgactcca attccattcc ttctaaagtg ttcaggagtt catttcatga caaaaccatg
     2041 ttgaagaagg acagagagaa tgtctctgtt tctgctactc atacagaagt gtccttattg
     2101 ggagacagag gtgatgggaa aagccccaaa cctagtaaat gtttccgatc tttcaaaaac
     2161 agtcctcaag aaaagtctct gaaacctgaa gaaagcgctc agcatcagaa ccatcctgat
     2221 gacatcaccc acacagccag gcaggagttg ctgaacaagg ctgctggctt actcacttcc
     2281 tctaactcgt ccctctgcaa tgaaagcagc ttggctttga ttggcagatt ggaaagtaca
     2341 tcttgtaaat tacaacttag gaagcaagaa atgagccatg aaactgagaa acagtgtttg
     2401 cattgcaaca gtattgacaa acagatttgc acaaataaat gcacagagaa aataaaagat
     2461 gagaatagcc cgggctctct cagtcatctc cagtgtgatg agtcaagagg tattgaccca
     2521 aaaataaaag tgactatgtt ggaaatgcct gactatttga acaagtacaa aactaattgt
     2581 tcaaataaag actccaaaag atcaaagaca tgtgagcaaa acattcagct tggcacagaa
     2641 aattatctca gtgaagatac tgagggttcc aaaagcacaa tatcagacca actaaaaact
     2701 gagcaggagg aaaacaaaga ttcagttgcc ggaaaacctc caagtgtaaa gcactgtctg
     2761 tctacaagcg aaagactgaa aaatgcagac atgttgagga ctacactgaa gcattcaagt
     2821 gtctggagga aacacgattt tcattccctg gatgggacat caaccagagc ctttcatcct
     2881 cagacagggc tgcctctcct ctcaagccca gttcctcaaa gaaaaacaca gtcaggttgc
     2941 tttgatctag acacgtcact actgcatctg agaagtctat cctccaaaag ctctcgaccg
     3001 tgtctgaaca ttgaagcgga cccaggtgtt catgaaaagc cttttttgag ttcaagtgct
     3061 ccaccaatca caagtcttag tctcctaggg aattttgagg aatcggttct gaattaccgt
     3121 ttagaccccc tcggcatagt tgatggcttc actgctgagg tgggagccag tgggactttc
     3181 tgccctacgc acttgactct gccggtggaa gtgtcgttct acagtgtttc ggatgataac
     3241 gctccctcgc cttatatggg tgtgattact ttagagtccc ttggtaaaag gggttatcga
     3301 gtacctcctt caggaacgat acaagtgacc ttattcaatc ccaataagac tgtggtgaag
     3361 atgtttgttg tcgtgtatga cctacgaagt atgccagcca atcaccagac attcctgcgg
     3421 cagaggacgt tttctgttcc tgttaaacaa gaaatgaaga gaagtattaa caaagagaat
     3481 gtccagcaca cggcacagtt actacgctac ctcatacacc tgaggttcca gagctctaaa
     3541 tctgggaaga tctacctcca tagagatgtc cggctcctgt tctctagaaa gtccatggag
     3601 gttgatagcg gtgctgctta tgaactcaag tcttacaccg aatcgccaac aaacccacag
     3661 ttttcaccaa gatgctgata agggagacgg attaaaagta tttgctcagt acccaagctt
     3721 gaacgtgagc attcaccgag tggaatacat ccaatgagag ccagtggagt ggagtggccc
     3781 tcctcttgtc ctggaccaga ttttattaaa ggacccctga actgagaccc atgactccta
     3841 agtggactgg aagcacccct gtcttcaccc ttttcgtact gttgaaacca cttcattgga
     3901 cagttgcaat agcaaaatcc ccagttagat tagtgtttac acattttatt tctgttattt
     3961 aatatttaat gttttcctta atagtcaagt gatgtttgtc tctagtgttc taatgtagca
     4021 caatctatgt aaaatcatac tatgtatttt tgacattaat gttgaaattg aaatatatgc
     4081 ataagtcttt aattttgtgt ggtgtgtttt aagtgctatt catttaagct actgaaaatg
     4141 agaatgaaat gttgggcttc tttaagatta atgcactatg caagcatgta tgcttttgat
     4201 atctctccag gttaggtttt aaagaactca ccagggctgt tcccaggggt ccgacaaagc
     4261 tgctcccatc ctcctggcaa acactcagcc tcctgcccat tctcatcctt ctaagatccc
     4321 ccccacccca aaaacattct attttccctg aatcactact gtagaggttt tactttaaat
     4381 tgctatccca tgctacataa ttttctcaca ctgttaaaaa gaatatgtac tttgaaaaga
     4441 atttaatatt tatattgtaa atatatgcaa aaaactaaaa
//
LOCUS       NM_001436467            3624 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus IQ motif containing H (Iqch), transcript variant
            3, mRNA.
ACCESSION   NM_001436467 XM_017595564
VERSION     NM_001436467.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_017595564.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.45846.1,
                                           SRR26360181.2259746.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000008.1  72978476-72978591   c
            117-239             JAXUCZ010000008.1  72965283-72965405   c
            240-328             JAXUCZ010000008.1  72964734-72964822   c
            329-443             JAXUCZ010000008.1  72954872-72954986   c
            444-560             JAXUCZ010000008.1  72940310-72940426   c
            561-681             JAXUCZ010000008.1  72914785-72914905   c
            682-810             JAXUCZ010000008.1  72911713-72911841   c
            811-932             JAXUCZ010000008.1  72901945-72902066   c
            933-971             JAXUCZ010000008.1  72900132-72900170   c
            972-1523            JAXUCZ010000008.1  72891516-72892067   c
            1524-1590           JAXUCZ010000008.1  72890677-72890743   c
            1591-1674           JAXUCZ010000008.1  72879267-72879350   c
            1675-1850           JAXUCZ010000008.1  72875386-72875561   c
            1851-2123           JAXUCZ010000008.1  72866121-72866393   c
            2124-2315           JAXUCZ010000008.1  72861335-72861526   c
            2316-2436           JAXUCZ010000008.1  72848274-72848394   c
            2437-2723           JAXUCZ010000008.1  72845413-72845699   c
            2724-2894           JAXUCZ010000008.1  72819954-72820124   c
            2895-2930           JAXUCZ010000008.1  72811070-72811105   c
            2931-2992           JAXUCZ010000008.1  72795168-72795229   c
            2993-3101           JAXUCZ010000008.1  72791557-72791665   c
            3102-3624           JAXUCZ010000008.1  72787701-72788223   c
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3624
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ motif containing H"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
     exon            1..116
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    6..8
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="upstream in-frame stop codon"
     CDS             66..3236
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="isoform 3 is encoded by transcript variant 3; IQ
                     domain-containing protein H"
                     /codon_start=1
                     /product="IQ domain-containing protein H isoform 3"
                     /protein_id="NP_001423396.1"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
                     /translation="MAQAQELNDPIGSILIQVHGDLHQLKEKLIQFSAEETRDPLDIQ
                     NLETAIQRTETGLKIHIERYLGIVNQEVIMTPVKSLDSPINSKWAIPTVIDQKSFIFP
                     MAPDKLWGLQKHRGSLPRGFTRAKPKVELNKKIMQDPENMHHRAAVNVSYGISLPRIK
                     QRKAHDKVRRVRKGSTISNLTVLPSSHRTDPHFIPIPVLQKDASKGILSMIERGLIPP
                     AARITFQNPPIKPQALPLHSFDEHRKVSITASFPIAHKPRLASEKVEESQQKQKAKVL
                     THLSTEEHSLPVTGKDKRSRGQPSRKSTRITTPSRIRRSPWDYILPVYNGSVDRAAPD
                     FIAFKTRYKLIWGSIFSFLEQIEKFLKDYAISEAKVRGKSLVSLLPEFELNNKLTKTD
                     VLAVLENPLHIQMLLNLPGQRFKGRDGRTEAAVKIQATWKSYKARTSFISYRQKKWAS
                     GVIALAWLLHCHKTRLKRIVEESRQRHLDNFRIRAKHLAANWSRIRTSRRTIIHIPSL
                     GYSQSVRKHISDLDIEQNRQLGRLCDILDVNVNVIYVCSSPMNDELKLYYKKLLSLQA
                     AVKSGYYGDRSDLQNRFRIITPEAVNIFTKHHMCLATHLMYSPKAIKRIKNLIQGEEA
                     YIVGGILHRDDLAVADMLNVPILASEPELVHLYSGKSGSKRIFDNANVPMPPGVYDIY
                     TYQQLIEQLSQLVTDNLGIRRWVFKMNMEFGGNGTAFCDIPSHLQCYKWVVKESNRFG
                     PEDWKKKWAQESALMKISEELAGVLAQHVQLVNEKQFPTWRKFLHMFLTQGGIIEAYP
                     PADSITNLTVDMLIEPDGEVRVLSMGDQFHADGPFISSGTTMPQTSVDPQVLNSLCLR
                     IGNICKEKDVVGYFSIDLVTFIDPSTLEQQVWTTGLNLSYSDQLAMTQLTLYLTNGYL
                     NCSLSTLEVPRFKEDAEREKKRLSIQAELMCKAHGIGYDLEDRQGTVFILYESLKRYK
                     LGMITIGVDLQGALMTFARNLFIIHQEISAPDMQGETNFKTTIDDIETILGVTEENKM
                     IFAGEKRRKEEEESLYEPVEIYTKTV"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     exon            117..239
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            329..443
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            682..810
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            811..932
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            933..971
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1523
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1674
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1850
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2123
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2315
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2436
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2723
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2894
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2930
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..2992
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3101
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3624
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctagaa gcgctccgga gaaggccata cctccggagc caagcgcctt ctgcctgcct
       61 cagtcatggc tcaggcccag gagctcaacg accccattgg atccatccta atccaggtcc
      121 atggggacct ccatcagtta aaggagaaat taattcaatt ctcagctgag gagacaagag
      181 accctctaga cattcaaaat cttgagacag caattcaaag aactgaaacg gggttaaaga
      241 ttcacattga gaggtatctc ggaattgtaa accaggaggt gataatgact cctgtgaaga
      301 gcttagactc ccctatcaat tccaaatggg cgattccaac tgtaattgac cagaaatcct
      361 ttatttttcc catggctccc gataaacttt ggggacttca aaaacatcgc ggttcacttc
      421 cacgcggctt tacaagagca aagccaaaag tagagttgaa caagaagatc atgcaggacc
      481 ctgagaacat gcaccacaga gctgctgtaa atgtgagcta tgggatcagt ttgccacgta
      541 ttaaacagag gaaagcacat gataaggttc ggcgggtaag aaaagggtcc acgatctcca
      601 acctcacagt tctgccatcc agtcatcgca ctgaccccca ttttatcccc atacctgtct
      661 tgcaaaagga tgccagtaaa gggatcttaa gtatgatcga acgagggctg atccccccag
      721 cagcaaggat tacctttcag aatccaccca ttaaacccca agcacttcct ctgcatagct
      781 ttgatgagca tcggaaggta tcaataacag cctcctttcc gatagctcat aagccacgcc
      841 tggcttcaga aaaagtggag gagtctcaac agaaacagaa agccaaggta ctcacacatc
      901 taagcacgga agaacacagt ctacctgtga cgggaaaaga caaaaggtca agaggacaac
      961 ccagtaggaa gagcacgagg attactacac cgtctaggat taggagatca ccatgggatt
     1021 acatcttgcc tgtttacaac ggctctgtag acagggcagc cccagacttt atagcattca
     1081 aaacacgtta caaattaatc tggggaagca ttttttcttt cctggaacaa attgagaaat
     1141 ttctcaagga ctatgcaata tcagaagcca aagtaagagg gaagagtctg gtgtccctgc
     1201 ttccagagtt tgagctgaac aacaaactta ccaaaactga cgttctggct gtgctagaga
     1261 acccgctcca catccagatg ctgctaaatc ttcctggaca gaggttcaag ggccgggacg
     1321 gaaggacaga ggctgccgtc aagatccaag ccacatggaa aagttataag gcaagaactt
     1381 ccttcatttc ttatcgccag aagaagtggg cctcgggagt gatcgccctg gcatggcttc
     1441 tacattgcca caaaacaaga ctaaagagga tagtggagga atctcgacag agacacctgg
     1501 ataacttccg aattcgagcc aagcatctgg cagccaactg gagtcgcatc aggacctcca
     1561 ggaggactat tatccatata ccatcattag gatattccca gtctgtgcga aaacacatat
     1621 ctgatttgga catagagcag aacaggcagt tggggaggct gtgtgacatc ctagatgtca
     1681 acgtcaatgt catctacgtc tgctccagtc ccatgaatga cgagttaaag ctgtactaca
     1741 aaaaactcct gagtctgcaa gcagctgtca aatcgggcta ctatggggat aggtctgacc
     1801 tgcaaaacag gttcagaatt atcacccctg aagctgtaaa catcttcact aaacatcaca
     1861 tgtgcctggc tactcacctg atgtacagtc ccaaggcaat caaaagaata aaaaatctca
     1921 tccaaggaga agaggcctac atcgtgggcg ggatcctcca cagagatgat ttagctgtgg
     1981 ctgacatgtt gaatgtaccc atcctggcct cagagcctga gctggttcac ctttacagtg
     2041 gcaagtctgg aagtaaacgg atctttgata acgctaatgt gccaatgcct cctggagtat
     2101 atgacatcta tacttaccag cagctgatag aacaattgag tcagttggtg actgataacc
     2161 tgggaatccg acgctgggtc tttaaaatga acatggaatt tggaggaaat gggacagcat
     2221 tttgcgacat cccttcccat ctacagtgct acaaatgggt ggtgaaggag agtaacagat
     2281 tcggccctga ggactggaag aagaagtggg cacaagagtc agctctgatg aagatctccg
     2341 aggagctggc gggcgtttta gcacagcacg tacagctagt caatgagaaa cagttcccga
     2401 catggagaaa attcctccac atgtttctca ctcaaggtgg catcattgaa gcatacccac
     2461 ctgcagacag catcaccaac ctcaccgtag acatgttgat agagcctgac ggagaagtca
     2521 gagtgctgtc aatgggggac cagtttcatg ctgatggccc ctttatttct tctggtacca
     2581 ccatgcctca gacttcagtg gatccccaag ttctcaattc tttgtgcctc cgaattggaa
     2641 atatctgcaa agagaaagat gtggttggtt atttttctat agatctggtg acttttattg
     2701 atccaagcac cttagagcag caggtatgga caacaggcct caacctctca tacagtgacc
     2761 agctagccat gacgcagctc accctgtacc tgacaaatgg ttatctgaat tgtagtctga
     2821 gcaccctgga agtgccccgt tttaaagaag atgcagaaag ggaaaagaaa cgtctgagca
     2881 tccaggcaga gctgatgtgt aaggcccatg gcatcggcta tgaccttgag gacagacaag
     2941 gaactgtttt tatattatat gaatctctga agagatacaa gttgggcatg ataacaatcg
     3001 gtgtggatct ccagggggcc ctcatgacct ttgctcgcaa tctcttcatc atccatcaag
     3061 aaatatcagc acctgatatg caaggcgaga ccaattttaa gactaccatt gatgatattg
     3121 aaaccatttt aggagtaaca gaagaaaata aaatgatatt tgcaggagaa aaacggcgca
     3181 aagaggagga agagagcctg tatgagcctg ttgagatata cacaaaaaca gtatgacttt
     3241 ggatacctgt ctaaagcgag aaaaaaggtt tgctttgtaa ttaatgtaaa agtgaggaag
     3301 ttagtttgct ttgtttgcca agagataaat cagaacaaat tgtaacataa tagtctttaa
     3361 aatctttgct tattttccag tgttatttta ctcattaagg ttaaacctac cggtgttttc
     3421 attgtgagtg ctaagaatcc cttcctcctc cccaaaacaa agaagccaga ggaaggcttt
     3481 ggcccactac tgctccactt cttttctcct gcttccaaaa gccacttagg gtcttcattt
     3541 aaaataccaa ataaaccaga gtgatcactt gtcaaaacac aaatgtcctc ttttcccaaa
     3601 ataaatgaaa tcagttttaa atga
//
LOCUS       NM_001436469            4277 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 5,
            mRNA.
ACCESSION   NM_001436469 XM_039081145
VERSION     NM_001436469.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081145.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.29092.1,
                                           SRR26643287.20616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000008.1  84575422-84575555
            135-251             JAXUCZ010000008.1  84576190-84576306
            252-436             JAXUCZ010000008.1  84629460-84629644
            437-639             JAXUCZ010000008.1  84630342-84630544
            640-765             JAXUCZ010000008.1  84630809-84630934
            766-2578            JAXUCZ010000008.1  84632504-84634316
            2579-2707           JAXUCZ010000008.1  84636524-84636652
            2708-2787           JAXUCZ010000008.1  84638961-84639040
            2788-2896           JAXUCZ010000008.1  84640128-84640236
            2897-3055           JAXUCZ010000008.1  84641283-84641441
            3056-3124           JAXUCZ010000008.1  84645727-84645795
            3125-3321           JAXUCZ010000008.1  84647790-84647986
            3322-4277           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4277
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..134
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            135..251
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    161..163
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             236..3475
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 1 is encoded by transcript variant 5;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 1"
                     /protein_id="NP_001423398.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLDFSSQRTTLKHSSVWRK
                     HDFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCL
                     NIEADPGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTF
                     CPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTV
                     VKMFVVVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRF
                     QSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    2879..3052
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    2879..3052
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3296..3469
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3296..3469
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            252..436
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            437..639
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            640..765
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2578
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2707
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2787
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2896
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3055
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3124
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3321
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..4277
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatcgtttg gaaaacgaag cagaagccat tgagtcagcc gtgtgccggt
      181 tggaagaacc cacacctgtg ttttacagca ctttgggtgg aaattggatg ccaaaatgaa
      241 gccagaccga gatgccttgg atgagtattt tgaatatgat gcagaggagt tcttggtctc
      301 tttggccttg ctgataactg aaggccgaac ccctgagtgt tccgtgaaag gccgtgcaga
      361 gagtttccac tgccctccag cgcagtctcg tttcccaggc gcagccagac atgagtgcag
      421 cgacaagctg gcccagtgtc gccaagccag acgaaccaga tctgaggtca cgctgttgtg
      481 gaaaaataat cttccaatca tggtagaagt gatgcttctg ccagattgct gctacagtga
      541 cgagggccct agcacagagg ggacagatct gaatgaccct gccattaaac aagatgcact
      601 gttactggag aggtggatct tggagccagt tccccgacag aatggcgatc gcttcatcga
      661 agagaaggca cttctgctgg ctgtcagatc attcgtgttt ttttctcagt taagtgcttg
      721 gctgagtgtt tctcatggtg ctattccacg aaacattctt tacagaatca gtgctgctga
      781 tgtcgacctg cagtggagtt tttcacagac tccaactgag catgtgtttc ccgttcccaa
      841 tgtctctcac aacgtggcct tgaaagtcag cgttcagtcc ttacccagac aagctcatta
      901 tccagttttg acctgtagta tccatactaa tattggtctg tatgagaaga gaattcagga
      961 acaggagctt cgagcctgtc agcaccgtgg ccctggtgaa gtggagtacc gttgtcccag
     1021 cagctctcag agtctgtgca gcaagcacac atggaccatg gcacctgtga gtgccctgca
     1081 tgtcagaagt ggcatgcctc ctgagtacac tgcagccatt agaaatgtca ggctctgccc
     1141 aggcacaggt agcaagtctg acaatggaac acctcaagcc agcgtcctgg gcttcagtgg
     1201 cactggagaa gtgaggtccc aggaggcatc agtgagaact ttcaaatcac tctctgtgat
     1261 cgattccagt gtctccagct gtcagagctc ccggcagcca gtaggggagc ctaacccttt
     1321 aatcgactcc ctgattcagg atcgacaaga agtcattgcc aggattgctc agcacttgat
     1381 tcactgtgac cccagctcct ctcgcatgtc tgaactcccc tttaacaccc cagagtccac
     1441 ttcacttagc ccaaagcttc acccagtttc acaggagagt gggtattcga gaagatgcaa
     1501 agaagcattc tctgtctctt ttgggagtcc agagtttggc tccccaggag acagcaagga
     1561 ggggaaagtg aaagagaagc tggaaaccag gcaaggagaa acctgtgcct ctcacagtcc
     1621 ctaccctcgg cagcctgctg gggaggcaaa cccactgatt ggctctttgc ttctggagcg
     1681 gcaggatgtc atagccagga tcgcacagca cttggagcac atcgacccca cagctcacat
     1741 tccccggcct gcgttcagca agcacgactc caattccatt ccttctaaag tgttcaggag
     1801 ttcatttcat gacaaaacca tgttgaagaa ggacagagag aatgtctctg tttctgctac
     1861 tcatacagaa gtgtccttat tgggagacag aggtgatggg aaaagcccca aacctagtaa
     1921 atgtttccga tctttcaaaa acagtcctca agaaaagtct ctgaaacctg aagaaagcgc
     1981 tcagcatcag aaccatcctg atgacatcac ccacacagcc aggcaggagt tgctgaacaa
     2041 ggctgctggc ttactcactt cctctaactc gtccctctgc aatgaaagca gcttggcttt
     2101 gattggcaga ttggaaagta catcttgtaa attacaactt aggaagcaag aaatgagcca
     2161 tgaaactgag aaacagtgtt tgcattgcaa cagtattgac aaacagattt gcacaaataa
     2221 atgcacagag aaaataaaag atgagaatag cccgggctct ctcagtcatc tccagtgtga
     2281 tgagtcaaga ggtattgacc caaaaataaa agtgactatg ttggaaatgc ctgactattt
     2341 gaacaagtac aaaactaatt gttcaaataa agactccaaa agatcaaaga catgtgagca
     2401 aaacattcag cttggcacag aaaattatct cagtgaagat actgagggtt ccaaaagcac
     2461 aatatcagac caactaaaaa ctgagcagga ggaaaacaaa gattcagttg ccggaaaacc
     2521 tccaagtgta aagcactgtc tgtctacaag cgaaagactg aaaaatgcag acatgttgga
     2581 cttttcctca cagaggacta cactgaagca ttcaagtgtc tggaggaaac acgattttca
     2641 ttccctggat gggacatcaa ccagagcctt tcatcctcag acagggctgc ctctcctctc
     2701 aagcccagtt cctcaaagaa aaacacagtc aggttgcttt gatctagaca cgtcactact
     2761 gcatctgaga agtctatcct ccaaaagctc tcgaccgtgt ctgaacattg aagcggaccc
     2821 aggtgttcat gaaaagcctt ttttgagttc aagtgctcca ccaatcacaa gtcttagtct
     2881 cctagggaat tttgaggaat cggttctgaa ttaccgttta gaccccctcg gcatagttga
     2941 tggcttcact gctgaggtgg gagccagtgg gactttctgc cctacgcact tgactctgcc
     3001 ggtggaagtg tcgttctaca gtgtttcgga tgataacgct ccctcgcctt atatgggtgt
     3061 gattacttta gagtcccttg gtaaaagggg ttatcgagta cctccttcag gaacgataca
     3121 agtgacctta ttcaatccca ataagactgt ggtgaagatg tttgttgtcg tgtatgacct
     3181 acgaagtatg ccagccaatc accagacatt cctgcggcag aggacgtttt ctgttcctgt
     3241 taaacaagaa atgaagagaa gtattaacaa agagaatgtc cagcacacgg cacagttact
     3301 acgctacctc atacacctga ggttccagag ctctaaatct gggaagatct acctccatag
     3361 agatgtccgg ctcctgttct ctagaaagtc catggaggtt gatagcggtg ctgcttatga
     3421 actcaagtct tacaccgaat cgccaacaaa cccacagttt tcaccaagat gctgataagg
     3481 gagacggatt aaaagtattt gctcagtacc caagcttgaa cgtgagcatt caccgagtgg
     3541 aatacatcca atgagagcca gtggagtgga gtggccctcc tcttgtcctg gaccagattt
     3601 tattaaagga cccctgaact gagacccatg actcctaagt ggactggaag cacccctgtc
     3661 ttcacccttt tcgtactgtt gaaaccactt cattggacag ttgcaatagc aaaatcccca
     3721 gttagattag tgtttacaca ttttatttct gttatttaat atttaatgtt ttccttaata
     3781 gtcaagtgat gtttgtctct agtgttctaa tgtagcacaa tctatgtaaa atcatactat
     3841 gtatttttga cattaatgtt gaaattgaaa tatatgcata agtctttaat tttgtgtggt
     3901 gtgttttaag tgctattcat ttaagctact gaaaatgaga atgaaatgtt gggcttcttt
     3961 aagattaatg cactatgcaa gcatgtatgc ttttgatatc tctccaggtt aggttttaaa
     4021 gaactcacca gggctgttcc caggggtccg acaaagctgc tcccatcctc ctggcaaaca
     4081 ctcagcctcc tgcccattct catccttcta agatcccccc caccccaaaa acattctatt
     4141 ttccctgaat cactactgta gaggttttac tttaaattgc tatcccatgc tacataattt
     4201 tctcacactg ttaaaaagaa tatgtacttt gaaaagaatt taatatttat attgtaaata
     4261 tatgcaaaaa actaaaa
//
LOCUS       NM_001436516            6458 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 38
            (Zbtb38), transcript variant 3, mRNA.
ACCESSION   NM_001436516 XM_063265583
VERSION     NM_001436516.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6458)
  AUTHORS   Miotto,B., Chibi,M., Xie,P., Koundrioukoff,S., Moolman-Smook,H.,
            Pugh,D., Debatisse,M., He,F., Zhang,L. and Defossez,P.A.
  TITLE     The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common
            fragile site stability
  JOURNAL   Cell Rep 7 (2), 575-587 (2014)
   PUBMED   24726359
REFERENCE   2  (bases 1 to 6458)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   3  (bases 1 to 6458)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 6458)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
REFERENCE   5  (bases 1 to 6458)
  AUTHORS   Kiefer,H., Chatail-Hermitte,F., Ravassard,P., Bayard,E., Brunet,I.
            and Mallet,J.
  TITLE     ZENON, a novel POZ Kruppel-like DNA binding protein associated with
            differentiation and/or survival of late postmitotic neurons
  JOURNAL   Mol Cell Biol 25 (5), 1713-1729 (2005)
   PUBMED   15713629
  REMARK    GeneRIF: ZENON is involved in the maintenance of panneuronal
            features and/or in the survival of mature neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265583.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1264456.1,
                                           SRR26360194.1264612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000008.1  106196350-106196614 c
            266-6458            JAXUCZ010000008.1  106161802-106167994 c
FEATURES             Location/Qualifiers
     source          1..6458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..6458
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
     exon            1..265
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="upstream in-frame stop codon"
     exon            266..6458
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..3877
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zenon; zinc finger protein expressed in neurons;
                     zinc finger transcription factor Kaiso"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001423445.1"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQE
                     TVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTN
                     GPRITNAFSIIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTL
                     AEHSYAVSSITEAYRSQPLREHDSSSSSGKTGKENGEALTTKAKPCRKPKTQTQDSDS
                     TTENMPLPLVTCPEVNQERSPQPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAA
                     EVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQIC
                     MRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRIGELSSAGSALSDADHMV
                     KFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIW
                     HTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYR
                     LLPMRCKRAPYKSYRNSSYESAQGNRQRNESPPDTFVIPNLPSSEMPTLNFQDGRNSL
                     TSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQALKTDLVDSAEVSISSIGNSVSTTL
                     QAEPVCVSSGEHSASVISYSGSVPSVIVHSSQFSSVIKHSNAIACLANSNHQSPSQPV
                     ASPSLIKDSKPEADKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLGGSSGKTT
                     NVVEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGR
                     KPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNY
                     KPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELDRCAEVKL
                     PPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHLTLKPYICELCAKQFQSSS
                     TLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETL
                     KIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKICKTAAA
                     LRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDSEDSDQKDDIKKPLLKMSFE"
     misc_feature    308..649
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    308..649
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    653..655
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3; propagated from
                     UniProtKB/Swiss-Prot (Q5EXX3.1); phosphorylation site"
     misc_feature    953..1267
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1160..1831
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Interaction with CBFA2T3.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3"
     misc_feature    1187..1468
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1187..1468
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1292..1354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1292..1354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1292..1294,1301..1303,1340..1342,1352..1354)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1292..1294,1301..1303,1340..1342,1352..1354)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1379..1438
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1379..1438
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1646..1648,1655..1657,1694..1696,1706..1708)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1646..1648,1655..1657,1694..1696,1706..1708)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1661..1663,1667..1669,1673..1675,1679..1684,
                     1691..1696,1703..1705,1745..1747,1751..1753,1763..1768,
                     1775..1780,1787..1789,1829..1831,1835..1837,1841..1843,
                     1847..1852,1859..1864)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1661..1663,1667..1669,1673..1675,1679..1684,
                     1691..1696,1703..1705,1745..1747,1751..1753,1763..1768,
                     1775..1780,1787..1789,1829..1831,1835..1837,1841..1843,
                     1847..1852,1859..1864)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1730..1792
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1730..1792
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1814..1870
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1814..1870
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2006..2197
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2456..2593
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2834..2911
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2948..3007
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3320..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3320..3382
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3320..3322,3329..3331,3368..3370,3380..3382)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3320..3322,3329..3331,3368..3370,3380..3382)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3335..3337,3341..3343,3347..3349,3353..3358,
                     3365..3370,3377..3379,3419..3421,3425..3427,3437..3442,
                     3449..3454,3461..3463,3503..3505,3509..3511,3515..3517,
                     3521..3526,3533..3538,3545..3547)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3335..3337,3341..3343,3347..3349,3353..3358,
                     3365..3370,3377..3379,3419..3421,3425..3427,3437..3442,
                     3449..3454,3461..3463,3503..3505,3509..3511,3515..3517,
                     3521..3526,3533..3538,3545..3547)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3359..3430
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3359..3430
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3398..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3398..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3404..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3404..3466
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3488..3550
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3488..3550
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3527..>3583
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3527..>3583
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3572..3634
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3572..3634
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3665..3727
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3665..3727
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3779..3874
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 acaaacccga gctgcttcct gaccctaccg gatcgcgttg agattctagt gcgacaccaa
       61 gcccctggaa ttgaaccgga cgttcaaagg cagggccctg cccccagggg ttgcagcctc
      121 ggcctccagc tcctactgca gcggtctgtc tgttgggaca attcaacagt cagcctttag
      181 acacttcttt gcaggtcagc tgataaataa cctgagattt taatctatct gcgcttccac
      241 tttattaact cctgctttgc ggtggatgac agtcatgtcc ctctccaggg acctcaagga
      301 cgactttcac agtgacacgg tgctctccat cctaaatgag cagcgcattc ggggcatctt
      361 atgtgatgtc accatcattg tggaggacac caagtttaaa gcccacagca atgtcctggc
      421 cgcctcaagc ctttatttca aaaacatctt ttggagccat acgatctgta tttccagtca
      481 tgtcctagag ctggatgatc tgaaagccga agtgtttaca gagattctta attacatcta
      541 cagctccacc gtggtggtca ggagacagga aaccgtcact gaccttgcag ctgcagggaa
      601 aaggctggga atatcattct tagaggacct tagtgaccgc aacttctcaa attccccagg
      661 tccttacgta gtttgcatca ctgaaaaggg cgtggttaaa gaagaaaaaa atgaaaaaag
      721 gcacgaagag ccagctgtca ctaatgggcc caggatcaca aacgcatttt ccatcattga
      781 gacggaaaat agcaatagca tgttttctcc cctggacttg agggcaagct tcaaaaaagt
      841 gtcagatgcc atgagaacca ctagcctttg ccaggagaga gccagtgtct gccccgaggc
      901 agagcctgtc cgcacgcttg ccgaacactc atatgccgtt tcttccatca ctgaggccta
      961 caggagtcag cctctgaggg aacatgacag cagcagttca tctggtaaaa cgggaaaaga
     1021 aaatggcgaa gctctcacca caaaagcaaa gccatgccga aagccaaaga cccaaaccca
     1081 ggattctgac tcaaccacag agaacatgcc actccctcta gtaacctgcc cagaggtgaa
     1141 tcaagaaaga agcccacagc cagctccaat tctgtcacac tcagaacctc ccagcagtga
     1201 aggagatgtc cattttccca gagaagatga aaaccagccc tctgagactc ctggtccccc
     1261 agcagcagag gtcccgcccc tcgtttataa ttgtagctgc tgctccaaat ccttcgacag
     1321 cagcacactg ctcggggccc acatgcagct gcacaagccg acgcaggacc cctttgtgtg
     1381 caagtactgc aacaagcagt tcaccaccct caacaggctg gaccggcacg agcagatctg
     1441 catgaggtcg agccacatgc ccatgccagg aggaaaccaa cccttcttag aaaactaccc
     1501 caccattgga caagatggag gttcattcac aagcccagat tcattggtgc cagaaagtag
     1561 gattggtgaa ctatccagcg ctgggagtgc cttgtcagac gcggaccaca tggtgaaatt
     1621 tgtgaatggg cagatgcttt acagctgcgt tgtgtgcaaa cgtagctatg tgactttgtc
     1681 cagcctccgg aggcacgcaa atgtccactc gtggagaaga acgtaccctt gtcattactg
     1741 caacaaggtc ttcgcactgg ctgagtacag gacacgacat gagatctggc acactggaga
     1801 gaggcggtac cagtgcattt tctgtcttga aacgtttatg acctactaca tactgaaaaa
     1861 ccatcagaag tcttttcatg ccatagatca cagactctcc atcagtaaaa aaacagcaaa
     1921 tggaggcttg aagcccaccg tctacccata caaactttac aggctcttgc ctatgagatg
     1981 caagcgggca ccttataaga gctaccggaa ttcttcctat gaaagtgctc aaggaaaccg
     2041 tcaaaggaat gaatccccac ctgacacctt cgtcattccg aatctgccaa gctctgaaat
     2101 gcccacactg aacttccaag atggcagaaa ctcgttgacc agcagccctg ccatcccagt
     2161 ggaaacacct tcatggcagg gtacacccac ttctgccaaa gtaaaaaatg cagaaggcct
     2221 caaatggagg aagcaggcac tgaaaaccga tctcgtcgat tcggctgagg tgtcgatttc
     2281 ttccattgga aactctgtca gcaccaccct gcaggcagag cccgtgtgtg tttcgagtgg
     2341 ggagcactcg gcctccgtga tcagctacag cggctcggtg ccctctgtca ttgtgcacag
     2401 cagccagttc tcgtcggtga tcaagcacag caatgccatt gcctgcctgg ccaacagcaa
     2461 ccaccagtcc ccttcacagc ctgtggcgag tccgtccctg atcaaggata gcaagcctga
     2521 ggcagataaa gccagtaaac tcgcaagcag acccaaaaac tctaaggaga aaaagaaaac
     2581 cgttccatgt aacaggggag aaataacaga ggaggcaaaa tatgttgctg atctcggagg
     2641 atcttcgggc aaaaccacaa atgtcgtcga agaaaccagt aagattgaaa cttatatagc
     2701 aaaacccgct ctgcccggca cctccacaaa tagcaatgtt gcaccccttt gccaaataac
     2761 agtgaaaatt gggaacgaag ccatcgtgaa aaggcatatc cttgggtcta agctgtttta
     2821 caaaagaggg agaaaaccca agtatcaaat gcaggaagag acattgcctc gggagagtga
     2881 ccccgaaacc cgtggagaca gccctcttgg gctctgccaa gctgactgtg tggagatgag
     2941 tgaagcattt gatgaagtga gtgaccagga ctccaccgat aagccgtggc gcccatacta
     3001 caactacaag cccaagaaga aatccaaaca gttaagaaaa ataaggaaag tcaagtggag
     3061 gaaggaacga gggagcagaa gccccgtggg tcggcgcagg tatccagctg agctggatcg
     3121 cgcagagatg ggtcggcgca ggtacccagc tgaactagat cgctgcgcag aggtgaaatt
     3181 gcccccagat aaggcctctg aagaagagga gaataaagag atgcccaagc tgcagtgcga
     3241 gctctgtgac ggtgacaaag cagcaggggc gggagccgaa ggcaagcccc accagcatct
     3301 cactctgaag ccttacatct gcgagctctg tgcgaagcag ttccagagct cctccacgct
     3361 caagatgcac atgagatgcc acactggcga gaagccctac cagtgcaaga cctgtgggcg
     3421 gcgcttctca gtgcagggca acctacagaa gcacgagcgc attcacctgg gcgtgaagga
     3481 gttcatctgt cagtattgta acaaggcttt cacgctgaac gagacactca agatccacga
     3541 aagaatccac acaggggaga agcgttacca ctgtcagttc tgctttcagg gtttcttata
     3601 tctctccaca aaaaggaacc acgagcggag gcatgtccgg gagcatgacg ggaaaggctt
     3661 tgcttgcttc cagtgcccca aaatatgcaa aacagctgct gccctcagaa tgcaccaaaa
     3721 gaagcactta ttcaagacct tgactaagca agaggaaaca gatgaccttt gccacgaaaa
     3781 ctccgatctc ttggagagtc aaccttgcac tgattcggaa gacagcgacc aaaaggatga
     3841 cataaaaaaa cctttgctga aaatgtcctt tgagtgacaa cagttagaaa ggtcttcaaa
     3901 attgtttgtg atttttttta tttttagttt tttaagtttt tttaagctta gttttgttca
     3961 cataatattc tcaaaggatg gggggttgtt aattttcctt tgtgtaaact ccccccaaaa
     4021 aggatcctaa caactatttt gggttttatc attcactcta cacagaatgc ataaaaacaa
     4081 actagctgaa tcctctaacg accgagtatt ttgtgaaggc taatgaagtt ctgagctgtg
     4141 ggattttgaa cagtggaaag agcagctgga ttttagccta atttaagcct ttctctcgcg
     4201 cactaatgag gtctgctgaa ctgttgttag tcactggaga gagtaagggt caggatcgtg
     4261 cagatggcat ctttgagaca tgctaaacga gctatgacag tatttattgc cattgagttt
     4321 ctgcactatt aatctttggt aaactgatgg gtatttacaa aatatctaac aatataactg
     4381 aacatatgta atgggtaacc taaagtagga cattctcata tcacctagag acacttttct
     4441 gcagcataaa ccttgtaaag tacgtatatg aatcactata acgtttagct gtctgtctgt
     4501 ccctagtaga gaaccacaag agcaatagac ctcagataac acggactgct gtagaaatca
     4561 gtagaacatt tggaatctgg ctgacgagca tgtgtgtgct tctcgatgga gtgctgtgct
     4621 gttctcctga agtatggctg agctgttagt tgaactggtc cactcaagtc acacagaaca
     4681 taggtcatgc cttatctatg agaaaacctt cctagactta cctgagatta cctatgccac
     4741 acagtcctct gcagtggcct cacctcagaa tgaagaatga tcacattctt cagaactctg
     4801 cagtcttcca gtcatcccaa ggccatggat gttggggggc tatcccaccc aacttctgtg
     4861 gtcaaataat cctggtccct cccattccac tgaagcagca gctggaggct gagggagaga
     4921 cacacctctg tggtaatcaa tctcagtccc ttggaaaggc cgaaagcctg attcctcagg
     4981 tttacatctc cttggagcta atgcagcaca caggtacata gtagtgaaaa gggccacaga
     5041 ctccttaccc ccactgataa catgaggaca gggggacctg atgcctccaa cagcagcatt
     5101 gtttttgagg gatggggaga tagaatgtgg aatgacagtg ttctgcccct tacaaacatg
     5161 actcgaaaca cccacaaagc cagatgcccc tccttcgtgt tcgcagacat tagctctctg
     5221 ttaaagcccc acttttactt ctaaatcctt ctaaatattg actcagactg tcaacattgc
     5281 cctcaaaagt ctccttgccc tacaggtatt ttttcatggg aactagggtc ctggaaagct
     5341 ggaactcaaa agattcttac tgttaacact ggcagaatag gagggaggga gaacacagcc
     5401 tacccttcca gcaccagaat gggcaaaact cagaacaggt taagtagtcg ttcccgctcg
     5461 ttggattgag taggtggaaa gccaaggctg gaaggttatc agaggactct ggtttctccc
     5521 acccagtgtt gtgttgcctc cacgaagaag gcttagcatg gtttggggta ggcaacattt
     5581 aaacacccag aaaaaaggac atgattcaag gtgaccttta tactgtagca ctttgctgtt
     5641 acccccaata tgtatctgca tttgtcattt gttcatctcc ctttacctac atacagtatt
     5701 atatagagga catggggaaa cgcaagcaat tgaactttgt tttgtccatt gtatatatgt
     5761 gcacccacac catttgagtt ttattgaagt agtcacaaag ggcttatgaa aatcactttt
     5821 gaattaataa ccagatgaca agcaatcctg tgatccacta atatgtttta tctcagttat
     5881 gattataaaa caattatgga tttaagttgt tttgatttaa ctacaaataa agttatatgt
     5941 attgatgtct cccatcaata tgtggatatt ttttaagtgg acttgtatgc tgataattct
     6001 agaccaaagt aaatatggca gaatatttat acatacaaat aattttgcaa atattttcta
     6061 taattgtatt attcatttaa aatgttgata gcttgtgtta gtttcaggga gggggtgtat
     6121 attttgataa aatacttgac tttgtaattc tgtatattct atacaattta tagcagagcc
     6181 attttaagac aactggttac atttttttgt tgattgtgta aatgttatga gtggtgttta
     6241 agtatgcatc aagtacataa tgaccaagta gaattaaagt gtaaacagtg aacatactgt
     6301 atgctgtaaa gatatattgt aacttgctgt ttttagcatc tgtattttgg ttaggaaata
     6361 tgattaaatg cagatgttaa gggttggaaa ggtctaattt tatttttaga aataatgaat
     6421 ataaatttgt tttgcttgat taaaatagct cattccta
//
LOCUS       NM_001436470            4471 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 6,
            mRNA.
ACCESSION   NM_001436470 XM_039081144
VERSION     NM_001436470.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081144.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.45271.1,
                                           SRR26643295.32500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000008.1  84575422-84575749
            329-445             JAXUCZ010000008.1  84576190-84576306
            446-630             JAXUCZ010000008.1  84629460-84629644
            631-833             JAXUCZ010000008.1  84630342-84630544
            834-959             JAXUCZ010000008.1  84630809-84630934
            960-2772            JAXUCZ010000008.1  84632504-84634316
            2773-2901           JAXUCZ010000008.1  84636524-84636652
            2902-2981           JAXUCZ010000008.1  84638961-84639040
            2982-3090           JAXUCZ010000008.1  84640128-84640236
            3091-3249           JAXUCZ010000008.1  84641283-84641441
            3250-3318           JAXUCZ010000008.1  84645727-84645795
            3319-3515           JAXUCZ010000008.1  84647790-84647986
            3516-4471           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4471
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..328
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            329..445
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    355..357
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             430..3669
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 1 is encoded by transcript variant 6;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 1"
                     /protein_id="NP_001423399.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLDFSSQRTTLKHSSVWRK
                     HDFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCL
                     NIEADPGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTF
                     CPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTV
                     VKMFVVVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRF
                     QSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    3073..3246
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3073..3246
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3490..3663
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3490..3663
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            446..630
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            631..833
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            834..959
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2772
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2901
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2981
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3090
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3249
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3318
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3515
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..4471
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatgtgagc ggcccggcgg ccgcagagag cagtgccggg aggaggagcg
      181 aggggtcccg gagggcggcg agcgggcggg ctatgggagc cgttcccggg tgggcagaga
      241 cacgcgtggg tcggcgcggc tgaggacatg cccagactct gctgctgacc ggctccggct
      301 ggaacccggc tactgaagcc tcggcgagcg tttggaaaac gaagcagaag ccattgagtc
      361 agccgtgtgc cggttggaag aacccacacc tgtgttttac agcactttgg gtggaaattg
      421 gatgccaaaa tgaagccaga ccgagatgcc ttggatgagt attttgaata tgatgcagag
      481 gagttcttgg tctctttggc cttgctgata actgaaggcc gaacccctga gtgttccgtg
      541 aaaggccgtg cagagagttt ccactgccct ccagcgcagt ctcgtttccc aggcgcagcc
      601 agacatgagt gcagcgacaa gctggcccag tgtcgccaag ccagacgaac cagatctgag
      661 gtcacgctgt tgtggaaaaa taatcttcca atcatggtag aagtgatgct tctgccagat
      721 tgctgctaca gtgacgaggg ccctagcaca gaggggacag atctgaatga ccctgccatt
      781 aaacaagatg cactgttact ggagaggtgg atcttggagc cagttccccg acagaatggc
      841 gatcgcttca tcgaagagaa ggcacttctg ctggctgtca gatcattcgt gtttttttct
      901 cagttaagtg cttggctgag tgtttctcat ggtgctattc cacgaaacat tctttacaga
      961 atcagtgctg ctgatgtcga cctgcagtgg agtttttcac agactccaac tgagcatgtg
     1021 tttcccgttc ccaatgtctc tcacaacgtg gccttgaaag tcagcgttca gtccttaccc
     1081 agacaagctc attatccagt tttgacctgt agtatccata ctaatattgg tctgtatgag
     1141 aagagaattc aggaacagga gcttcgagcc tgtcagcacc gtggccctgg tgaagtggag
     1201 taccgttgtc ccagcagctc tcagagtctg tgcagcaagc acacatggac catggcacct
     1261 gtgagtgccc tgcatgtcag aagtggcatg cctcctgagt acactgcagc cattagaaat
     1321 gtcaggctct gcccaggcac aggtagcaag tctgacaatg gaacacctca agccagcgtc
     1381 ctgggcttca gtggcactgg agaagtgagg tcccaggagg catcagtgag aactttcaaa
     1441 tcactctctg tgatcgattc cagtgtctcc agctgtcaga gctcccggca gccagtaggg
     1501 gagcctaacc ctttaatcga ctccctgatt caggatcgac aagaagtcat tgccaggatt
     1561 gctcagcact tgattcactg tgaccccagc tcctctcgca tgtctgaact cccctttaac
     1621 accccagagt ccacttcact tagcccaaag cttcacccag tttcacagga gagtgggtat
     1681 tcgagaagat gcaaagaagc attctctgtc tcttttggga gtccagagtt tggctcccca
     1741 ggagacagca aggaggggaa agtgaaagag aagctggaaa ccaggcaagg agaaacctgt
     1801 gcctctcaca gtccctaccc tcggcagcct gctggggagg caaacccact gattggctct
     1861 ttgcttctgg agcggcagga tgtcatagcc aggatcgcac agcacttgga gcacatcgac
     1921 cccacagctc acattccccg gcctgcgttc agcaagcacg actccaattc cattccttct
     1981 aaagtgttca ggagttcatt tcatgacaaa accatgttga agaaggacag agagaatgtc
     2041 tctgtttctg ctactcatac agaagtgtcc ttattgggag acagaggtga tgggaaaagc
     2101 cccaaaccta gtaaatgttt ccgatctttc aaaaacagtc ctcaagaaaa gtctctgaaa
     2161 cctgaagaaa gcgctcagca tcagaaccat cctgatgaca tcacccacac agccaggcag
     2221 gagttgctga acaaggctgc tggcttactc acttcctcta actcgtccct ctgcaatgaa
     2281 agcagcttgg ctttgattgg cagattggaa agtacatctt gtaaattaca acttaggaag
     2341 caagaaatga gccatgaaac tgagaaacag tgtttgcatt gcaacagtat tgacaaacag
     2401 atttgcacaa ataaatgcac agagaaaata aaagatgaga atagcccggg ctctctcagt
     2461 catctccagt gtgatgagtc aagaggtatt gacccaaaaa taaaagtgac tatgttggaa
     2521 atgcctgact atttgaacaa gtacaaaact aattgttcaa ataaagactc caaaagatca
     2581 aagacatgtg agcaaaacat tcagcttggc acagaaaatt atctcagtga agatactgag
     2641 ggttccaaaa gcacaatatc agaccaacta aaaactgagc aggaggaaaa caaagattca
     2701 gttgccggaa aacctccaag tgtaaagcac tgtctgtcta caagcgaaag actgaaaaat
     2761 gcagacatgt tggacttttc ctcacagagg actacactga agcattcaag tgtctggagg
     2821 aaacacgatt ttcattccct ggatgggaca tcaaccagag cctttcatcc tcagacaggg
     2881 ctgcctctcc tctcaagccc agttcctcaa agaaaaacac agtcaggttg ctttgatcta
     2941 gacacgtcac tactgcatct gagaagtcta tcctccaaaa gctctcgacc gtgtctgaac
     3001 attgaagcgg acccaggtgt tcatgaaaag ccttttttga gttcaagtgc tccaccaatc
     3061 acaagtctta gtctcctagg gaattttgag gaatcggttc tgaattaccg tttagacccc
     3121 ctcggcatag ttgatggctt cactgctgag gtgggagcca gtgggacttt ctgccctacg
     3181 cacttgactc tgccggtgga agtgtcgttc tacagtgttt cggatgataa cgctccctcg
     3241 ccttatatgg gtgtgattac tttagagtcc cttggtaaaa ggggttatcg agtacctcct
     3301 tcaggaacga tacaagtgac cttattcaat cccaataaga ctgtggtgaa gatgtttgtt
     3361 gtcgtgtatg acctacgaag tatgccagcc aatcaccaga cattcctgcg gcagaggacg
     3421 ttttctgttc ctgttaaaca agaaatgaag agaagtatta acaaagagaa tgtccagcac
     3481 acggcacagt tactacgcta cctcatacac ctgaggttcc agagctctaa atctgggaag
     3541 atctacctcc atagagatgt ccggctcctg ttctctagaa agtccatgga ggttgatagc
     3601 ggtgctgctt atgaactcaa gtcttacacc gaatcgccaa caaacccaca gttttcacca
     3661 agatgctgat aagggagacg gattaaaagt atttgctcag tacccaagct tgaacgtgag
     3721 cattcaccga gtggaataca tccaatgaga gccagtggag tggagtggcc ctcctcttgt
     3781 cctggaccag attttattaa aggacccctg aactgagacc catgactcct aagtggactg
     3841 gaagcacccc tgtcttcacc cttttcgtac tgttgaaacc acttcattgg acagttgcaa
     3901 tagcaaaatc cccagttaga ttagtgttta cacattttat ttctgttatt taatatttaa
     3961 tgttttcctt aatagtcaag tgatgtttgt ctctagtgtt ctaatgtagc acaatctatg
     4021 taaaatcata ctatgtattt ttgacattaa tgttgaaatt gaaatatatg cataagtctt
     4081 taattttgtg tggtgtgttt taagtgctat tcatttaagc tactgaaaat gagaatgaaa
     4141 tgttgggctt ctttaagatt aatgcactat gcaagcatgt atgcttttga tatctctcca
     4201 ggttaggttt taaagaactc accagggctg ttcccagggg tccgacaaag ctgctcccat
     4261 cctcctggca aacactcagc ctcctgccca ttctcatcct tctaagatcc cccccacccc
     4321 aaaaacattc tattttccct gaatcactac tgtagaggtt ttactttaaa ttgctatccc
     4381 atgctacata attttctcac actgttaaaa agaatatgta ctttgaaaag aatttaatat
     4441 ttatattgta aatatatgca aaaaactaaa a
//
LOCUS       NM_001436509            4450 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 6, mRNA.
ACCESSION   NM_001436509 XM_006243007
VERSION     NM_001436509.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4450)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4450)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4450)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4450)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4450)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4450)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243007.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1014            JAXUCZ010000008.1  58249618-58249694
            1015-1163           JAXUCZ010000008.1  58254695-58254843
            1164-1291           JAXUCZ010000008.1  58256533-58256660
            1292-1387           JAXUCZ010000008.1  58258205-58258300
            1388-1567           JAXUCZ010000008.1  58264169-58264348
            1568-1791           JAXUCZ010000008.1  58266333-58266556
            1792-1862           JAXUCZ010000008.1  58267575-58267645
            1863-2091           JAXUCZ010000008.1  58268925-58269153
            2092-2283           JAXUCZ010000008.1  58271693-58271884
            2284-2423           JAXUCZ010000008.1  58273167-58273306
            2424-2603           JAXUCZ010000008.1  58273482-58273661
            2604-2699           JAXUCZ010000008.1  58274560-58274655
            2700-2878           JAXUCZ010000008.1  58276058-58276236
            2879-2957           JAXUCZ010000008.1  58276347-58276425
            2958-3037           JAXUCZ010000008.1  58277395-58277474
            3038-3161           JAXUCZ010000008.1  58277966-58278089
            3162-3357           JAXUCZ010000008.1  58279354-58279549
            3358-4450           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4450
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3533
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 6 is encoded by transcript variant 6;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     6"
                     /protein_id="NP_001423438.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGAM
                     VEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQVI
                     YMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVIE
                     FASTKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPEDA
                     LPNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKN
                     CISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYNDI
                     SVTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVEL
                     RQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCLS
                     SEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEHKEAEPEKPQETNLAEQSEQAAEVK
                     DTEAAAPPNSEVSEVEIPSVGRILVRSDADGYDEEVMLSPAMQGVLLAIAKARQTFDR
                     DGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQ
                     FADRNLSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGLE
                     LFQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFE
                     TNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQ
                     LCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    591..2063
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..2063
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1917..1919,1971..1973)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1917..1919,1971..1973)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    2691..3530
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2691..3530
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1014
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1163
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1291
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1387
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1567
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1791
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1862
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2091
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2283
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2423
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2603
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2699
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2878
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2957
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3037
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3357
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..4450
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacaa tcccaggact aaatctgaaa
      961 accccatggt gcagctgttc tacggtacct tcctgacaga aggggtccga gaaggaaaac
     1021 ccttttgtaa caacgagacc ttcggccagt accctcttca ggtaaacggt taccacaact
     1081 tagacgagtg tttggaaggg gccatggtgg aaggtgacat tgcgctgctt ccttctgatc
     1141 gctcagtgaa atacggacaa gagcgttggt ttacaaagct gcctccagtg ttgaccttcg
     1201 aactctccag atttgagttt aatcagtctc ttgggcagcc tgagaaaatt cataataagc
     1261 tggaatttcc tcaggttatt tatatggata ggtacatgta caaaagcaaa gagcttatcc
     1321 gaagtaagag agagagcatt cgaaagttga aggaggaaat acaagttctg cagcagaaat
     1381 tagaaaggta tgtgaagtac ggctccggtc catctcgctt cccactcccc gacatgttga
     1441 aatacgttat tgaatttgcc agtacaaaac ctgcctctga aagctgtctg tctggaagtg
     1501 ttgagcatat gacgttacca cttccttctg tgcactgccc gatttctgac ctcacagcca
     1561 aggaaagttc aagtcccaaa agctgctctc agaatgctga gggttccttt tcctctccgg
     1621 aagatgctct acccaactct gaggtaatga atgggccatt tacttctcct cactcttccc
     1681 tggaaatgcc tgcaccccca ccagctcctc ggacagtcac agatgaggaa atgaatttcg
     1741 ttaagacctg tcttcagagg tggcggagtg aaattgaaca ggatatacaa gacttaaaga
     1801 attgtatctc gagcaccacc caggctattg agcagatgta ctgtgatcct cttcttcgtc
     1861 aggtgcctta tcgcttacat gcagttcttg ttcatgaagg acaagccagt gcagggcact
     1921 actgggcgta catctataac cagccccggc agatctggct caaatacaac gacatctctg
     1981 tcactgagtc ttcctgggaa gaacttgaaa gagattctta cgggggcctg agaaatgtca
     2041 gcgcatactg cttgatgtat atcaatgaca agttgcccca ctgcagtgca gaggcagcgc
     2101 atggtgaatc tgatcagact gcagaagtgg aagccctgtc tgtggaactc aggcagtaca
     2161 ttcaggaaga taactggagg tttgagcaag aggtggagga atgggaggaa gaacagtcct
     2221 gtaagatccc acagatggag tcctccccaa actcttcctc acaggatttt tccacatcac
     2281 aagagtcttc agcagcgtcc tcgcatggcg ttcgatgttt gtcttctgaa catgctgtga
     2341 ttgcaaagga gcagactgcc caggccatcg caaacacggc tcatgcctat gagaagagcg
     2401 gggtagaagc agccttgagt gagcataagg aagctgaacc cgagaagccc caggaaacaa
     2461 accttgcaga gcagtcagaa caggctgcag aggtcaaaga cacagaggct gctgccccac
     2521 ctaactctga ggtctctgaa gtggagatcc ccagtgtggg aaggattctg gttagatctg
     2581 atgcagatgg ctatgatgag gaggtgatgc tgagccctgc catgcaaggg gtcctcctgg
     2641 ccatagctaa ggcgcgccag acctttgacc gagacgggtc tgaagcaggg cttattaagg
     2701 catttcatga agagtactcc aggctctatc agcttgccaa agagacaccc acctctcaca
     2761 gtgatcctcg ccttcagcat gttctcgtct actttttcca aaatgaagca cccaagaggg
     2821 tagtagaacg aacccttctg gaacagtttg cagatagaaa ccttagctat gatgagagat
     2881 ctatcagtat catgaaggtg gctcaggcca aactgatgga aattggtcca gaggacatga
     2941 acatggaaga gtataagagg tggcatgaag actatagtct gttccgaaag gtgtctgtgt
     3001 acctgctaac gggcctggaa ctcttccaaa aaggaaagta ccaggaagct ttgtcctacc
     3061 tggtgtacgc gtaccagagc aatgctggcc tgctggtgaa ggggccccgc aggggcgtga
     3121 aggagtctgt gattgctttg taccgcagaa aatgccttct ggagttgaat gccaaggctg
     3181 cttctctttt tgaaacaaat gacgaccatt ctgtaacaga gggcattaat gtgatgaatg
     3241 agctgatcat tccctgcatc cacctgatca ttaataatga catttccaag gacgaccttg
     3301 atgccatcga ggtcatgagg aaccactggt gctcttacct ggggaaggac atcgcagaaa
     3361 atctgcagct gtgtttaggg gagttcctac ccaggcttct agatccttcc gcagaaatca
     3421 tcgtcctaaa ggagcctcca actattcgac cgaattctcc ctatgatctt tgcagccggt
     3481 ttgcagctgt catggagtcc attcaaggag tttcaacagt aacagtgaag taaactgcac
     3541 atggacggtc aagactcatt ttggtctcca gtcacctgcc agttacacgg cagtctgttg
     3601 ttgcagactc ccctggagag agagattggg tgtctgagca agatttagac cctctgccct
     3661 ctctgatatg tgtttaaggg attaaggata aagttgcgca tttaggtaca gaatcatgag
     3721 agctctctca ctgaagaagg caggagcccg gtgcattaag gttttgaatt atcccagaag
     3781 acctgaattg cctttttaaa tctcccataa taattaccct tcgggcgcct gtctcatcag
     3841 aactgagccg gaggaacagt ttctggttct tttgtcaagt tcaggtgacg tttctaagtc
     3901 cttagctacc agagattggc aacaggggcc ttgcctggct cttgacagta acacaaaggg
     3961 tgctgctgag cctttccctc cacacaaggg tagagcgtaa ggcttcgccc accatgaagc
     4021 cacaggaaag ctgcctccat tttcggtctg tttatatttc agataaacca gaaaacctca
     4081 cactcagtct tgagtgaaag agaagcaagc atcctgggct ctcaccccag tgctggtgta
     4141 aagctgcaca agggacattt aatagctaat taagcaacat tgtggagatt gtcacatgca
     4201 ggtgtctaag gctacctggc ctgatagaat tttgattctc tctttccttt tttttttttt
     4261 agaaataagg gatgtgaatt tatatagaga gagaccatct atctgtgtat atgtagagaa
     4321 gctgcttttt aaagaacttt taattgggaa ttcatgtttt aacaaaattt taaggattaa
     4381 cgaggaatca tgggagggaa gaacacaact atgcagattt tataaatgtg caataaaagt
     4441 atttgtttta
//
LOCUS       NM_001436474            4187 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 3,
            mRNA.
ACCESSION   NM_001436474 XM_039081141
VERSION     NM_001436474.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081141.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.216771.1,
                                           SRR26643287.20621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  84597170-84597330
            162-346             JAXUCZ010000008.1  84629460-84629644
            347-549             JAXUCZ010000008.1  84630342-84630544
            550-675             JAXUCZ010000008.1  84630809-84630934
            676-2488            JAXUCZ010000008.1  84632504-84634316
            2489-2617           JAXUCZ010000008.1  84636524-84636652
            2618-2697           JAXUCZ010000008.1  84638961-84639040
            2698-2806           JAXUCZ010000008.1  84640128-84640236
            2807-2965           JAXUCZ010000008.1  84641283-84641441
            2966-3034           JAXUCZ010000008.1  84645727-84645795
            3035-3231           JAXUCZ010000008.1  84647790-84647986
            3232-4187           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4187
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..161
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             125..3385
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 3 is encoded by transcript variant 3;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 3"
                     /protein_id="NP_001423403.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MVFSGNKGLRRQDALDEYFEYDAEEFLVSLALLITEGRTPECSV
                     KGRAESFHCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLL
                     PDCCYSDEGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSF
                     VFFSQLSAWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKV
                     SVQSLPRQAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCS
                     KHTWTMAPVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVR
                     SQEASVRTFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCD
                     PSSSRMSELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEG
                     KVKEKLETRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAH
                     IPRPAFSKHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPK
                     PSKCFRSFKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNE
                     SSLALIGRLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGS
                     LSHLQCDESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLS
                     EDTEGSKSTISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLDFSSQRTTLK
                     HSSVWRKHDFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSS
                     KSSRPCLNIEADPGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAE
                     VGASGTFCPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTL
                     FNPNKTVVKMFVVVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLR
                     YLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    2789..2962
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    2789..2962
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3206..3379
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3206..3379
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            162..346
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            347..549
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            550..675
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            676..2488
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2617
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2697
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2806
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2965
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3034
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3231
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..4187
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttgtga gaagcctgca cgggaagcgg agcacccagc gcttgctccg cgctcgctca
       61 ctctgctccc gtgctttccc tctgcggctg acagtgtagc agctgacagc cagaggcttc
      121 cagtatggtt ttcagtggga acaaagggct ccgcagacaa gatgccttgg atgagtattt
      181 tgaatatgat gcagaggagt tcttggtctc tttggccttg ctgataactg aaggccgaac
      241 ccctgagtgt tccgtgaaag gccgtgcaga gagtttccac tgccctccag cgcagtctcg
      301 tttcccaggc gcagccagac atgagtgcag cgacaagctg gcccagtgtc gccaagccag
      361 acgaaccaga tctgaggtca cgctgttgtg gaaaaataat cttccaatca tggtagaagt
      421 gatgcttctg ccagattgct gctacagtga cgagggccct agcacagagg ggacagatct
      481 gaatgaccct gccattaaac aagatgcact gttactggag aggtggatct tggagccagt
      541 tccccgacag aatggcgatc gcttcatcga agagaaggca cttctgctgg ctgtcagatc
      601 attcgtgttt ttttctcagt taagtgcttg gctgagtgtt tctcatggtg ctattccacg
      661 aaacattctt tacagaatca gtgctgctga tgtcgacctg cagtggagtt tttcacagac
      721 tccaactgag catgtgtttc ccgttcccaa tgtctctcac aacgtggcct tgaaagtcag
      781 cgttcagtcc ttacccagac aagctcatta tccagttttg acctgtagta tccatactaa
      841 tattggtctg tatgagaaga gaattcagga acaggagctt cgagcctgtc agcaccgtgg
      901 ccctggtgaa gtggagtacc gttgtcccag cagctctcag agtctgtgca gcaagcacac
      961 atggaccatg gcacctgtga gtgccctgca tgtcagaagt ggcatgcctc ctgagtacac
     1021 tgcagccatt agaaatgtca ggctctgccc aggcacaggt agcaagtctg acaatggaac
     1081 acctcaagcc agcgtcctgg gcttcagtgg cactggagaa gtgaggtccc aggaggcatc
     1141 agtgagaact ttcaaatcac tctctgtgat cgattccagt gtctccagct gtcagagctc
     1201 ccggcagcca gtaggggagc ctaacccttt aatcgactcc ctgattcagg atcgacaaga
     1261 agtcattgcc aggattgctc agcacttgat tcactgtgac cccagctcct ctcgcatgtc
     1321 tgaactcccc tttaacaccc cagagtccac ttcacttagc ccaaagcttc acccagtttc
     1381 acaggagagt gggtattcga gaagatgcaa agaagcattc tctgtctctt ttgggagtcc
     1441 agagtttggc tccccaggag acagcaagga ggggaaagtg aaagagaagc tggaaaccag
     1501 gcaaggagaa acctgtgcct ctcacagtcc ctaccctcgg cagcctgctg gggaggcaaa
     1561 cccactgatt ggctctttgc ttctggagcg gcaggatgtc atagccagga tcgcacagca
     1621 cttggagcac atcgacccca cagctcacat tccccggcct gcgttcagca agcacgactc
     1681 caattccatt ccttctaaag tgttcaggag ttcatttcat gacaaaacca tgttgaagaa
     1741 ggacagagag aatgtctctg tttctgctac tcatacagaa gtgtccttat tgggagacag
     1801 aggtgatggg aaaagcccca aacctagtaa atgtttccga tctttcaaaa acagtcctca
     1861 agaaaagtct ctgaaacctg aagaaagcgc tcagcatcag aaccatcctg atgacatcac
     1921 ccacacagcc aggcaggagt tgctgaacaa ggctgctggc ttactcactt cctctaactc
     1981 gtccctctgc aatgaaagca gcttggcttt gattggcaga ttggaaagta catcttgtaa
     2041 attacaactt aggaagcaag aaatgagcca tgaaactgag aaacagtgtt tgcattgcaa
     2101 cagtattgac aaacagattt gcacaaataa atgcacagag aaaataaaag atgagaatag
     2161 cccgggctct ctcagtcatc tccagtgtga tgagtcaaga ggtattgacc caaaaataaa
     2221 agtgactatg ttggaaatgc ctgactattt gaacaagtac aaaactaatt gttcaaataa
     2281 agactccaaa agatcaaaga catgtgagca aaacattcag cttggcacag aaaattatct
     2341 cagtgaagat actgagggtt ccaaaagcac aatatcagac caactaaaaa ctgagcagga
     2401 ggaaaacaaa gattcagttg ccggaaaacc tccaagtgta aagcactgtc tgtctacaag
     2461 cgaaagactg aaaaatgcag acatgttgga cttttcctca cagaggacta cactgaagca
     2521 ttcaagtgtc tggaggaaac acgattttca ttccctggat gggacatcaa ccagagcctt
     2581 tcatcctcag acagggctgc ctctcctctc aagcccagtt cctcaaagaa aaacacagtc
     2641 aggttgcttt gatctagaca cgtcactact gcatctgaga agtctatcct ccaaaagctc
     2701 tcgaccgtgt ctgaacattg aagcggaccc aggtgttcat gaaaagcctt ttttgagttc
     2761 aagtgctcca ccaatcacaa gtcttagtct cctagggaat tttgaggaat cggttctgaa
     2821 ttaccgttta gaccccctcg gcatagttga tggcttcact gctgaggtgg gagccagtgg
     2881 gactttctgc cctacgcact tgactctgcc ggtggaagtg tcgttctaca gtgtttcgga
     2941 tgataacgct ccctcgcctt atatgggtgt gattacttta gagtcccttg gtaaaagggg
     3001 ttatcgagta cctccttcag gaacgataca agtgacctta ttcaatccca ataagactgt
     3061 ggtgaagatg tttgttgtcg tgtatgacct acgaagtatg ccagccaatc accagacatt
     3121 cctgcggcag aggacgtttt ctgttcctgt taaacaagaa atgaagagaa gtattaacaa
     3181 agagaatgtc cagcacacgg cacagttact acgctacctc atacacctga ggttccagag
     3241 ctctaaatct gggaagatct acctccatag agatgtccgg ctcctgttct ctagaaagtc
     3301 catggaggtt gatagcggtg ctgcttatga actcaagtct tacaccgaat cgccaacaaa
     3361 cccacagttt tcaccaagat gctgataagg gagacggatt aaaagtattt gctcagtacc
     3421 caagcttgaa cgtgagcatt caccgagtgg aatacatcca atgagagcca gtggagtgga
     3481 gtggccctcc tcttgtcctg gaccagattt tattaaagga cccctgaact gagacccatg
     3541 actcctaagt ggactggaag cacccctgtc ttcacccttt tcgtactgtt gaaaccactt
     3601 cattggacag ttgcaatagc aaaatcccca gttagattag tgtttacaca ttttatttct
     3661 gttatttaat atttaatgtt ttccttaata gtcaagtgat gtttgtctct agtgttctaa
     3721 tgtagcacaa tctatgtaaa atcatactat gtatttttga cattaatgtt gaaattgaaa
     3781 tatatgcata agtctttaat tttgtgtggt gtgttttaag tgctattcat ttaagctact
     3841 gaaaatgaga atgaaatgtt gggcttcttt aagattaatg cactatgcaa gcatgtatgc
     3901 ttttgatatc tctccaggtt aggttttaaa gaactcacca gggctgttcc caggggtccg
     3961 acaaagctgc tcccatcctc ctggcaaaca ctcagcctcc tgcccattct catccttcta
     4021 agatcccccc caccccaaaa acattctatt ttccctgaat cactactgta gaggttttac
     4081 tttaaattgc tatcccatgc tacataattt tctcacactg ttaaaaagaa tatgtacttt
     4141 gaaaagaatt taatatttat attgtaaata tatgcaaaaa actaaaa
//
LOCUS       NM_001436494            5149 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor related to kappa B binding protein
            (Nfrkb), transcript variant 4, mRNA.
ACCESSION   NM_001436494 XM_063265389
VERSION     NM_001436494.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265389.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.582442.1,
                                           SRR26643287.19721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000008.1  38090030-38090098
            70-242              JAXUCZ010000008.1  38092744-38092916
            243-444             JAXUCZ010000008.1  38095209-38095410
            445-572             JAXUCZ010000008.1  38098165-38098292
            573-747             JAXUCZ010000008.1  38099310-38099484
            748-849             JAXUCZ010000008.1  38100022-38100123
            850-923             JAXUCZ010000008.1  38100738-38100811
            924-1008            JAXUCZ010000008.1  38101595-38101679
            1009-1189           JAXUCZ010000008.1  38102404-38102584
            1190-1298           JAXUCZ010000008.1  38103121-38103229
            1299-1425           JAXUCZ010000008.1  38103788-38103914
            1426-1491           JAXUCZ010000008.1  38104177-38104242
            1492-1571           JAXUCZ010000008.1  38105285-38105364
            1572-1618           JAXUCZ010000008.1  38105453-38105499
            1619-1676           JAXUCZ010000008.1  38106236-38106293
            1677-1851           JAXUCZ010000008.1  38106533-38106707
            1852-1958           JAXUCZ010000008.1  38108447-38108553
            1959-2082           JAXUCZ010000008.1  38110471-38110594
            2083-2162           JAXUCZ010000008.1  38111060-38111139
            2163-2377           JAXUCZ010000008.1  38111280-38111494
            2378-2648           JAXUCZ010000008.1  38111574-38111844
            2649-2861           JAXUCZ010000008.1  38112380-38112592
            2862-3629           JAXUCZ010000008.1  38114925-38115692
            3630-3736           JAXUCZ010000008.1  38118990-38119096
            3737-3872           JAXUCZ010000008.1  38119994-38120129
            3873-5149           JAXUCZ010000008.1  38120227-38121503
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5149
                     /gene="Nfrkb"
                     /note="nuclear factor related to kappa B binding protein"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
     exon            1..69
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            70..242
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    84..86
                     /gene="Nfrkb"
                     /note="upstream in-frame stop codon"
     CDS             108..3998
                     /gene="Nfrkb"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 4"
                     /protein_id="NP_001423423.1"
                     /db_xref="GeneID:315523"
                     /db_xref="RGD:1310558"
                     /translation="MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPTDTVEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLSSQQQYFHRLLRQILASRSDLLEM
                     ARTSGPALPFRHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSW
                     LPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKHHEKRKHQPDHPD
                     LLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKLIKSEAEDLA
                     EPLSNTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQ
                     ASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVE
                     FKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKQENEDSSDAMTPVPRVTDYV
                     VRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHS
                     LLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSG
                     ALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPP
                     SKVKSSNKEGSVKGLSGPSEPSQMSLSDSSMPPTPVTPVTPTTPALPTPISPPPVSAV
                     SRSGSTTVSEPAKSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQTTARVVSHSSSAG
                     LPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKVVPQAVVATVPVK
                     GQTTAASVQRPGPAQTGLTVTSLPAAVSPGSKTAMSSPGSSAPSASTTAVIQNVTGQN
                     IIKQVSITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPD
                     MMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVPS
                     SAPAGTTVVKVTPDLKPTETSSSAFRLMPALGVSVADQKGKNTVASSEAKPAATIRIV
                     QGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINATVSKTVAVASGAT
                     STPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMKGKSVVTAPIIK
                     GNLGANLSGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVP
                     ASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    231..566
                     /gene="Nfrkb"
                     /note="DEUBAD domain found in nuclear factor related to
                     kappa-B-binding protein (NFRKB) and similar proteins;
                     Region: DEUBAD_NFRKB; cd21865"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    order(252..254,276..278,288..290,300..302,312..314,
                     324..332,336..338,357..359,369..371,381..383,396..407,
                     414..419,426..428,438..440,477..479,489..491,498..503,
                     510..512,522..524,531..536,552..557,564..566)
                     /gene="Nfrkb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439381"
     misc_feature    1281..1541
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    1281..1541
                     /gene="Nfrkb"
                     /note="NFRKB Winged Helix-like; Region: NFRKB_winged;
                     pfam14465"
                     /db_xref="CDD:433973"
     misc_feature    <2151..2765
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2151..2765
                     /gene="Nfrkb"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3048..>3668
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <3048..>3668
                     /gene="Nfrkb"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            243..444
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            445..572
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            573..747
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            748..849
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            850..923
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1008
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1189
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1298
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1425
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1491
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1571
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1618
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1676
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1851
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1958
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2082
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2162
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2377
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2648
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2861
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3629
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3736
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3872
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..5149
                     /gene="Nfrkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggagcga gcgcgtccgg gagcccacgg ccggacgagc cccgggtgag acccgcggac
       61 ccggctgagg gtgtattttt aggtagtgta cctgtggaga agaaacaatg gattccttgg
      121 atcacatgct gacagatccc ctagaacttg gtccttgtgg agatggtcac agtacaggga
      181 tcatggagga ctgccttctg ggtggaacca gggttagtct gcctgaagac ctgctggagg
      241 atcctgaaat attctttgac gtcgtcagcc tctccacatg gcaggaagta ctaagtgact
      301 ctcagcgtga acatctccag cagtttctgc cgcagtttcc tacagacact gtagagcagc
      361 agaatgagct catccttgcc ctattcagtg gggagaactt ccgcttcgga aaccctctgc
      421 acatcgccca gaagctcttc cgagatggac actttaaccc tgaggtggtc aagtatcggc
      481 agctctgctt caagtcacag tacaagcggt acctcagctc ccaacagcag tatttccacc
      541 ggctgctgag acagattctt gcttccagaa gtgatctcct ggagatggct cgcacgagcg
      601 gcccggctct tccctttcga cacaagcacc attcaccatc ccgaagcccg gaggagcggg
      661 agtggcggac ccagcagcgt tacctgaaag tcttgaggga agtgaaggag gagtgtggcg
      721 acactgccct gtcgtctgat gaggaggatc tcagctcatg gcttccaagc tctccagcac
      781 gctctcctag tcctgcggtg cccctgaggg tggtgcccac gctttccacc acggatatga
      841 aaactgcaga taaaatagaa ctgggggaca gtgacctgaa gttaatgtta aagaaacacc
      901 atgagaagcg gaaacatcaa ccagatcacc cagacctttt gacaggggat ctgactctca
      961 gcgacatcat gactcgagta aatgccggca ggaagggctc tctagcagcc ttgtatgatt
     1021 tggctgttct taaaaaaaag gtgaaggaaa aggaggagaa gaaaaagaag aaaataaagt
     1081 tgattaaatc ggaggcagag gatctggctg agcccctaag caatactgaa ggggtcccaa
     1141 cgctctccca ggccccctct cccctggcaa tatcgtctat caaggaagaa cccctggaag
     1201 acatcaagcc ttgtcttgga atcaatgaaa tatcttccag ttttttctct cttctgttag
     1261 agatcttgct gctggagagt caggctagcc ttcctatgct ggaggaccgg gttttggatt
     1321 ggcagtcttc tccagccagc tccctcaaca gctggttctc tgctgccccc aactgggctg
     1381 agttggtgtt gcctgctctg cagtatcttg ctggagaaag ccgagcagtt ccttccagtt
     1441 tttctccatt tgttgaattc aaagagaaaa cccagcagtg gaaattgctt ggtcaatctc
     1501 aagataatga aaaggaatta gccgctctct tccacttgtg gctagaaacc aaagaccagg
     1561 ctttctgtaa gcaggaaaat gaagacagct cagatgccat gacacctgtg cctcgagtaa
     1621 ctgactatgt ggttcggcct agcacaggag aggagaaacg ggtttttcaa gagcaggagc
     1681 gttacaggta tagccaaccc cataaggcat tcacctttcg catgcatggc tttgagtctg
     1741 tggtggggcc agtgaagggc gtgtttgaca aggagacctc cctcaacaag gctcgtgagc
     1801 actcactgct gcgctctgac cggcctgcct atgtcaccat tctgtctctt gttcgggatg
     1861 ctgcggctcg gctgcctaat ggagaaggca ctcgggcaga gatctgtgag ctgctcaagg
     1921 actctcagtt tcttgctcct gatgtcacca gcactcaggt gaacacggta gtgagtggcg
     1981 cactggatcg attgcattat gagaaggacc cttgtgtgaa atacgacatt ggtcggaagc
     2041 tgtggatcta cctgcatcgt gaccggagtg aggaagagtt tgaacggatc catcaagctc
     2101 aagcagcagc agctaaagcc agaaaagctc ttcagcaaaa acccaaaccg ccatccaagg
     2161 tgaagtccag taataaggag ggctccgtga agggccttag tggtccttct gagcccagcc
     2221 agatgagcct cagtgactcc agcatgccac ctaccccagt tacgcctgta acccccacca
     2281 cgccagcatt gcctacccct atctctcctc cacctgtgtc agcggtgagc agaagtggct
     2341 ctaccactgt ctctgagcca gccaagtcta gttcaggtgt tcttctggtg tcctcaccaa
     2401 caatgccaca gctaggaacg atgctttccc ctgcttccat ccagactccg cccagttctc
     2461 agaccactgc tcgggttgtc agccattcca gctcagcagg actgccccag gttcgggtag
     2521 tagcccagcc cagccttcct gctgtttccc agcagtcagt agggccagca cagccactac
     2581 cccagatgcc agcaggacca cagatccgtg tgccagtcac cgctacccaa accaaagtag
     2641 taccccaggc agttgtggct acagttccag tcaaggggca gactacagcg gcctctgtgc
     2701 aacggcctgg acctgcacag acaggactta cagtgacgag tcttcctgct gcagttagcc
     2761 ccgggagcaa gacagccatg agttctcctg ggagctctgc tccaagtgcc tccacaaccg
     2821 ccgtcattca gaatgtcaca ggacagaaca tcatcaagca ggtgtcaatc actggacagc
     2881 ttggtgtgaa gccccagaca ggcaacagca ttccactcac agccacaaac ttccgtatcc
     2941 agggtaaaga tgtactgcgc ctgccgcctt cttccatcac cacagatgcc aagggccaga
     3001 cggttctgag aatcactcca gacatgatgg ccacactggc caagtctcag gtcaccacag
     3061 tcaagttgac tcaggacctc tttggggcag gtagcggcac tgcaggcaaa ggcatctctg
     3121 ctaccttgca tgtgacttcc aaccctgtcc atgcggctga cagccctgcc aaggcccctt
     3181 cagccagtgt tccttcatca gctccagcgg gcactaccgt ggtcaaagta actcctgatc
     3241 tcaagccaac agaaacctcc agttcagctt ttcgcttgat gccagctctt ggcgtgagtg
     3301 tggcagatca gaaggggaag aacacagtgg cctcttcaga agcaaaacct gctgccacaa
     3361 tccgcattgt gcaggggctg ggagtgatgc ctcctaaagc aggccagacc attactgttg
     3421 cagcacatgc aaagcaagga gcctctgttg ctggtgggtc tggaactgtc cattcttcaa
     3481 ctgtgtcctt acccagtatc aatgccactg tgtctaagac tgtggctgtg gcttctggag
     3541 caacaagcac ccccatcagc atcgggactg gagcccccac cgtgcgacag gttcctgtta
     3601 acactacagt tgtgtccaca tcccagtctg ggaagctgcc taccaggatc acagttcctc
     3661 tctctgtgat tagccagcca atgaagggca agagcgtggt cacagccccc atcatcaaag
     3721 gcaaccttgg agccaatctc agtgggctgg gtcgcaacat catcctcaca accatgccag
     3781 cgggtgctaa gctcattgct ggcaataagc cagtgagttt cctcaccgcc cagcagttgc
     3841 agcagcttca gcagcaaggt caggctacac aggtacgcat ccagactgtg ccagcatccc
     3901 atctgcaaca gggcacagct tccggctcct ccaaagccgt gtccactgtt gttgtgacca
     3961 cagctccatc tcctaaacaa gcacctgagc agcagtgact gagaagaaag gcggcttctt
     4021 taagagacca ggcctggttt atctcggctg acagaaaggg agcagggagg ctgcaccatt
     4081 cttctgagct gtcctgcttg aggcagggtg gtggagagtg atggcaactg tggcctagat
     4141 tgtgctgcca cactccagag tgaagccctt tttagggttc cagggatgat ctgttatcct
     4201 ggactaccag gaagagggaa ggaacatcag agtctgggga ggtcacagtc acacaagccg
     4261 gggttacctc ctgaatgttg ggttcccagg gagcaggcct gccagttggt gagtggaccg
     4321 gcagggaata agcctcattc tgtgtgagga ttttactttt tagtttctga tcttctccgt
     4381 gacttgttga gatgtgagtt ttgtgtccag agaatttttg tgtaacttat ttttttaaag
     4441 aacctactct acgtctttta tcaaatagaa acctgggctt cagtgcccct aaactgatca
     4501 cttacccctt caaccagaat gagagcatag caagactctt aatagtttgg cggcttactt
     4561 gataatggag aggttatata gtaagaaaat gtaggccttg agttagcatg gaccccctca
     4621 agtgggacta gttcaatgcc gtgtactaaa tatgggcatc tgaatctcgg ttgtccctat
     4681 gtcttctctt gtgggcattg tccttgacaa gcctgttcat ggaagttcag agcttttgga
     4741 caggagtagg ggaagatgag gtgctgctct caccgtgcac ttgcttacag cccagacatt
     4801 gcacattctc cttgctgtag aacagccatt gctaaccaga cccttggagc tggccacttg
     4861 actgggacag agaagaaatg gggaggtggg ggcaggggta ggcactgcct ggcagtgcca
     4921 tcttgagggg aaaggatgtt tttattctgg ccatttcata tttctcagcc accaccagcc
     4981 acagacaggg ctcagaaggg tactttacaa agtccaagta cttaatgtac taggtgtatc
     5041 ttaacgtgtc ttgctgtggt gcaggggtgg gtaggaaaac ctttctgcag ggatagtgct
     5101 tccctgtctc tttgtgaaaa tatccaaatt attaaaaaca tatctttaa
//
LOCUS       NM_001108144            4261 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 7, mRNA.
ACCESSION   NM_001108144 XM_001070037 XM_236240
VERSION     NM_001108144.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4261)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4261)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4261)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4261)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4261)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4261)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001108144.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-713             JAXUCZ010000008.1  58246803-58246877
            714-851             JAXUCZ010000008.1  58247452-58247589
            852-925             JAXUCZ010000008.1  58248648-58248721
            926-1005            JAXUCZ010000008.1  58249615-58249694
            1006-1154           JAXUCZ010000008.1  58254695-58254843
            1155-1282           JAXUCZ010000008.1  58256533-58256660
            1283-1378           JAXUCZ010000008.1  58258205-58258300
            1379-1558           JAXUCZ010000008.1  58264169-58264348
            1559-1782           JAXUCZ010000008.1  58266333-58266556
            1783-1853           JAXUCZ010000008.1  58267575-58267645
            1854-2082           JAXUCZ010000008.1  58268925-58269153
            2083-2274           JAXUCZ010000008.1  58271693-58271884
            2275-2414           JAXUCZ010000008.1  58273167-58273306
            2415-2510           JAXUCZ010000008.1  58274560-58274655
            2511-2689           JAXUCZ010000008.1  58276058-58276236
            2690-2768           JAXUCZ010000008.1  58276347-58276425
            2769-2848           JAXUCZ010000008.1  58277395-58277474
            2849-2972           JAXUCZ010000008.1  58277966-58278089
            2973-3168           JAXUCZ010000008.1  58279354-58279549
            3169-4261           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4261
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3344
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 7 is encoded by transcript variant 7;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     7"
                     /protein_id="NP_001101614.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQELQYLF
                     ALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSN
                     PRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGAMVEG
                     DIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQVIYMD
                     RYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVIEFAS
                     TKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPEDALPN
                     SEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNCIS
                     STTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYNDISVT
                     ESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVELRQY
                     IQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCLSSEH
                     AVIAKEQTAQAIANTAHAYEKSGVEAALSEVMLSPAMQGVLLAIAKARQTFDRDGSEA
                     GLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLEQFADRN
                     LSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKG
                     KYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDH
                     SVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQLCLGE
                     FLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    282..350
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    303..305
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    591..2054
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..2054
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1908..1910,1962..1964)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1908..1910,1962..1964)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    1218..1220
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    1539..1709
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1758..1760
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5I043; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    2199..2276
                     /gene="Usp28"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZJ96.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2250..2252
                     /gene="Usp28"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     misc_feature    2502..3341
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2502..3341
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    3252..3254
                     /gene="Usp28"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96RU2; propagated from
                     UniProtKB/Swiss-Prot (D3ZJ96.2); phosphorylation site"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..713
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            714..851
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            852..925
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1005
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1154
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1282
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1378
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1558
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1782
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1853
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2082
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2274
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2414
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2510
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2689
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2768
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2848
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2972
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3168
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..4261
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtt gcctgaattt cgaagacttg
      661 ttctcagtta cagcctgcca cagaacattc ttgaaaattg tcgaagtcac actgaaaaaa
      721 gaaatatcat gtttatgcaa gagcttcagt atttatttgc tctgttattg ggatcaaatc
      781 ggaaatttgt agatccttct gctgccctgg atctactgaa gggggccttc cgatcctcag
      841 aggagcaaca gcaagatgtg agtgaattca cacacaagct cctggattgg ctggaggatg
      901 cgttccagct agctgttaat gttaacagca atcccaggac taaatctgaa aaccccatgg
      961 tgcagctgtt ctacggtacc ttcctgacag aaggggtccg agaaggaaaa cccttttgta
     1021 acaacgagac cttcggccag taccctcttc aggtaaacgg ttaccacaac ttagacgagt
     1081 gtttggaagg ggccatggtg gaaggtgaca ttgcgctgct tccttctgat cgctcagtga
     1141 aatacggaca agagcgttgg tttacaaagc tgcctccagt gttgaccttc gaactctcca
     1201 gatttgagtt taatcagtct cttgggcagc ctgagaaaat tcataataag ctggaatttc
     1261 ctcaggttat ttatatggat aggtacatgt acaaaagcaa agagcttatc cgaagtaaga
     1321 gagagagcat tcgaaagttg aaggaggaaa tacaagttct gcagcagaaa ttagaaaggt
     1381 atgtgaagta cggctccggt ccatctcgct tcccactccc cgacatgttg aaatacgtta
     1441 ttgaatttgc cagtacaaaa cctgcctctg aaagctgtct gtctggaagt gttgagcata
     1501 tgacgttacc acttccttct gtgcactgcc cgatttctga cctcacagcc aaggaaagtt
     1561 caagtcccaa aagctgctct cagaatgctg agggttcctt ttcctctccg gaagatgctc
     1621 tacccaactc tgaggtaatg aatgggccat ttacttctcc tcactcttcc ctggaaatgc
     1681 ctgcaccccc accagctcct cggacagtca cagatgagga aatgaatttc gttaagacct
     1741 gtcttcagag gtggcggagt gaaattgaac aggatataca agacttaaag aattgtatct
     1801 cgagcaccac ccaggctatt gagcagatgt actgtgatcc tcttcttcgt caggtgcctt
     1861 atcgcttaca tgcagttctt gttcatgaag gacaagccag tgcagggcac tactgggcgt
     1921 acatctataa ccagccccgg cagatctggc tcaaatacaa cgacatctct gtcactgagt
     1981 cttcctggga agaacttgaa agagattctt acgggggcct gagaaatgtc agcgcatact
     2041 gcttgatgta tatcaatgac aagttgcccc actgcagtgc agaggcagcg catggtgaat
     2101 ctgatcagac tgcagaagtg gaagccctgt ctgtggaact caggcagtac attcaggaag
     2161 ataactggag gtttgagcaa gaggtggagg aatgggagga agaacagtcc tgtaagatcc
     2221 cacagatgga gtcctcccca aactcttcct cacaggattt ttccacatca caagagtctt
     2281 cagcagcgtc ctcgcatggc gttcgatgtt tgtcttctga acatgctgtg attgcaaagg
     2341 agcagactgc ccaggccatc gcaaacacgg ctcatgccta tgagaagagc ggggtagaag
     2401 cagccttgag tgaggtgatg ctgagccctg ccatgcaagg ggtcctcctg gccatagcta
     2461 aggcgcgcca gacctttgac cgagacgggt ctgaagcagg gcttattaag gcatttcatg
     2521 aagagtactc caggctctat cagcttgcca aagagacacc cacctctcac agtgatcctc
     2581 gccttcagca tgttctcgtc tactttttcc aaaatgaagc acccaagagg gtagtagaac
     2641 gaacccttct ggaacagttt gcagatagaa accttagcta tgatgagaga tctatcagta
     2701 tcatgaaggt ggctcaggcc aaactgatgg aaattggtcc agaggacatg aacatggaag
     2761 agtataagag gtggcatgaa gactatagtc tgttccgaaa ggtgtctgtg tacctgctaa
     2821 cgggcctgga actcttccaa aaaggaaagt accaggaagc tttgtcctac ctggtgtacg
     2881 cgtaccagag caatgctggc ctgctggtga aggggccccg caggggcgtg aaggagtctg
     2941 tgattgcttt gtaccgcaga aaatgccttc tggagttgaa tgccaaggct gcttctcttt
     3001 ttgaaacaaa tgacgaccat tctgtaacag agggcattaa tgtgatgaat gagctgatca
     3061 ttccctgcat ccacctgatc attaataatg acatttccaa ggacgacctt gatgccatcg
     3121 aggtcatgag gaaccactgg tgctcttacc tggggaagga catcgcagaa aatctgcagc
     3181 tgtgtttagg ggagttccta cccaggcttc tagatccttc cgcagaaatc atcgtcctaa
     3241 aggagcctcc aactattcga ccgaattctc cctatgatct ttgcagccgg tttgcagctg
     3301 tcatggagtc cattcaagga gtttcaacag taacagtgaa gtaaactgca catggacggt
     3361 caagactcat tttggtctcc agtcacctgc cagttacacg gcagtctgtt gttgcagact
     3421 cccctggaga gagagattgg gtgtctgagc aagatttaga ccctctgccc tctctgatat
     3481 gtgtttaagg gattaaggat aaagttgcgc atttaggtac agaatcatga gagctctctc
     3541 actgaagaag gcaggagccc ggtgcattaa ggttttgaat tatcccagaa gacctgaatt
     3601 gcctttttaa atctcccata ataattaccc ttcgggcgcc tgtctcatca gaactgagcc
     3661 ggaggaacag tttctggttc ttttgtcaag ttcaggtgac gtttctaagt ccttagctac
     3721 cagagattgg caacaggggc cttgcctggc tcttgacagt aacacaaagg gtgctgctga
     3781 gcctttccct ccacacaagg gtagagcgta aggcttcgcc caccatgaag ccacaggaaa
     3841 gctgcctcca ttttcggtct gtttatattt cagataaacc agaaaacctc acactcagtc
     3901 ttgagtgaaa gagaagcaag catcctgggc tctcacccca gtgctggtgt aaagctgcac
     3961 aagggacatt taatagctaa ttaagcaaca ttgtggagat tgtcacatgc aggtgtctaa
     4021 ggctacctgg cctgatagaa ttttgattct ctctttcctt tttttttttt tagaaataag
     4081 ggatgtgaat ttatatagag agagaccatc tatctgtgta tatgtagaga agctgctttt
     4141 taaagaactt ttaattggga attcatgttt taacaaaatt ttaaggatta acgaggaatc
     4201 atgggaggga agaacacaac tatgcagatt ttataaatgt gcaataaaag tatttgtttt
     4261 a
//
LOCUS       NM_001436485            3552 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 4,
            mRNA.
ACCESSION   NM_001436485 XM_006243744
VERSION     NM_001436485.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243744.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2189213.1,
                                           SRR26360172.1064650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000008.1  118095904-118096260
            358-417             JAXUCZ010000008.1  118097040-118097099
            418-747             JAXUCZ010000008.1  118106884-118107213
            748-1779            JAXUCZ010000008.1  118112261-118113292
            1780-1957           JAXUCZ010000008.1  118120474-118120651
            1958-2112           JAXUCZ010000008.1  118121209-118121363
            2113-2227           JAXUCZ010000008.1  118122735-118122849
            2228-2336           JAXUCZ010000008.1  118131517-118131625
            2337-2488           JAXUCZ010000008.1  118131953-118132104
            2489-2579           JAXUCZ010000008.1  118132470-118132560
            2580-3552           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3552
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..357
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            358..417
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            418..747
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    424..426
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             439..2772
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423414.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <454..582
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <454..582
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    2236..2718
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    2236..2718
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            748..1779
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1957
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2112
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2227
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2336
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2488
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2579
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..3552
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctcagc tgtggcccgt gggctagaac ggcttccggg gcgcgcgctt ccccgcgacc
       61 cccagttttg tggcgcgcgc cctgctgttg gtttggttgc tcgcgctgtc cggagtacgc
      121 gcaggacgcc ccttccgaga ggagggtcgg cggcctggct gacgaccggc ttgctgagtg
      181 gggaaggttg agggttgggc ccttgccctc gtgacgtccc gggcagcggt ggcctaggtc
      241 tgcggagaaa catagcggct ttgcggtctg gcttgcggct ccgctcctcc gtgaggcgga
      301 caggattgct tgtactaacc gaagaatgct gttacttaag cgaggcccat gtactggaat
      361 gttagaagtc ttaagaactc aggacaagca gcagacatac atgcaacatg gtgactggaa
      421 ccctaaggac tctgcaatat gaataattct ctagagaaca ccatctcatt tgaagagtac
      481 atccgagtaa aggcgaggtc tgtcccgcaa cacaggatga aggaatttct ggactcgctg
      541 gcttctaagg gaccagaagc tcttcaggag ttccagcagt ctgccaccac caccatggtg
      601 taccagcagg gtgggaactg catttataca gacagcactg aagtggctgg gtctttgctt
      661 gaacttgctt gtccagtcac aaccagtgtt caaccacaaa ctcagcaaga gcagcagatc
      721 caggttcagc agccacagca ggttcaggta caggtgcagg tacagcagtc tccacagcag
      781 gtctcagctc agcagctttc cccgcagttc accgttcacc agcctgctga gcaacccatc
      841 caggtccagg tgcagatcca gggccaagca ccacagtccg cagccccctc catccagact
      901 ccatcactgc agagccccag cccctcgcag ctgcaagcag cccagatcca ggtgcagcac
      961 gtgcaggcag cgcagcagat ccaggctgca gaaatcccag aggagcatat cccacatcaa
     1021 cagatccaag ctcagttggt ggcaggccaa tctcttgctg ggggccagca gattcaaatt
     1081 cagaccgtgg gcgctctttc cccaccaccc tcccagcagg gctcacccag ggaaggggag
     1141 cggagggttg gcacagccag tgtccttcaa ccagtgaaga aacgcaaagt ggacatgccc
     1201 atcaccgtgt cctatgccat ctcagggcag ccagtggcca ccgtgctggc cattccacaa
     1261 ggccagcaac agagttacgt gtctttgagg ccagacttac tgacagtaga cagtgcccac
     1321 ctgtacagcg ccactgggac cataactagc cctacaggag aaacttggac catccctgtt
     1381 tattccgccc agccccgggg ggaccctcag cagcagagca ttacccacat tgccattccc
     1441 caggaagcct acaatgcagt tcacgtcagt ggctcaccca cggctctggc agctgtaaag
     1501 ctggaggatg acaaggagaa gatggtgggc accacatccg tagtgaagaa ctcccatgaa
     1561 gaggtagtgc agacccttgc aaactctctc tttccagcac agttcatgaa tggcaacatc
     1621 cacattccag tggctgtgca ggctgtagca ggcacgtacc agaatacggc tcagactgta
     1681 catatatggg acccacagca gcagccgcaa cagcaaactg cacaagaaca gacaccacca
     1741 cagccacagc aacagcagca gctgcaggtc acttgttcag cacaaactgt tcaggtcgct
     1801 gaagttgagc cacagtcaca accgcagcct tcaccagagc ttttgcttcc aaattcactg
     1861 aagccagaag aagggctaga agtatggaaa aactgggctc agaccaagaa tgctgaacta
     1921 gaaaaggatg ctcaaaacag attggccccc attgggaggc gccagttgct acgattccaa
     1981 gaagatctga tctcatctgc tgtggctgaa ttgaattatg gcctttgttt aatgacacga
     2041 gaagctcgga atggagaagg tgaaccctat gacccagatg tactctacta cattttcttg
     2101 tgtatacaga agtatctttt tgaaaatgga agagtagatg acatattctc tgatctttac
     2161 tatgttcgtt ttaccgaatg gctacatgaa gttctgaagg acgtgcagcc ccgggtcact
     2221 ccacttggct atgttctgcc cagccacgtg actgaagaga tgctgtggga atgcaagcag
     2281 cttggggcac attccccttc gacactgctg accaccctca tgttcttcaa caccaagtac
     2341 tttctgttga agacagtaga tcagcacatg aagctggcgt tctccaaggt cctccggcag
     2401 acaaagaaga gcccctcgaa tcctaaggat aaaagcacta gtatccgcta cctgaaggcc
     2461 ctcggaatac atcagactgg ccagaaagtt acagatgaca tgtatgcaga acagacagaa
     2521 aatccagaga acccattaag gtgtcccatc aagctctacg atttctacct cttcaaatgc
     2581 ccccagagtg tgaaaggccg aaatgacacc ttttacctga ctcctgagcc tgttgtggct
     2641 cccaacagcc cgatctggta ctcagtccag cctatcagcc gagagcagat gggacagatg
     2701 ctgacccgga tcctggttat acgagagatt caagaagcca ttgccgtggc caacgcaacc
     2761 accatgcact gaggtgcctc agccacagga aaaaaaaaaa tccaggaaaa accagacaga
     2821 cttttacact aaaggagagg cctccatttt tttctttttc tttttccttc aattcgtagt
     2881 tctaatgctt ttcaggcgac ttctgttaaa aatgtaaaag acaatgttgc cctctttgca
     2941 tcttcataaa atgggcagac cccctggttc atgggtatat ggttttccta gaacttgatg
     3001 tcctaggaag tggttggctt ttacctttct tttccttttt tttcttttgt ctgggctgga
     3061 gtgtggggga agggacttgg actgtatgga gaaatatagg cccttccctt cctcaaggca
     3121 gatggagcag ccgatgaatc aaccctcctg caaaccccca cctttcactc tggaccggca
     3181 ggcttaacca ctcggagcca cgatttttct tttttttttt tttttttttt tttttaaatg
     3241 ctcagacata aacttagcat cttgatggaa taaaaatgag gggaacttca attatgattt
     3301 ttattaaaga caatttctat tacacccttc tttatgacaa gtgacataga tgttaaagta
     3361 aaaactttac catgcttttt tttttttttt tttttttttt tggcctaaca ttgaggcctt
     3421 aaacctgagg ctcctgtgcc tgatggaatt cttgtaacat acacttgtgt atcatataaa
     3481 gataccactc tttctcttat gtattcttat tctagttgtt tattaagaat gacaagcacg
     3541 tcttttcaac aa
//
LOCUS       NM_001398742             752 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus ripply transcriptional repressor 2 (Ripply2),
            transcript variant 1, mRNA.
ACCESSION   NM_001398742 XM_039082552
VERSION     NM_001398742.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 752)
  AUTHORS   Takahashi,J., Ohbayashi,A., Oginuma,M., Saito,D., Mochizuki,A.,
            Saga,Y. and Takada,S.
  TITLE     Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism
            underlying the rostro-caudal patterning within a somite
  JOURNAL   Dev Biol 342 (2), 134-145 (2010)
   PUBMED   20346937
REFERENCE   2  (bases 1 to 752)
  AUTHORS   Chan,T., Kondow,A., Hosoya,A., Hitachi,K., Yukita,A.,
            Okabayashi,K., Nakamura,H., Ozawa,H., Kiyonari,H., Michiue,T.,
            Ito,Y. and Asashima,M.
  TITLE     Ripply2 is essential for precise somite formation during mouse
            early development
  JOURNAL   FEBS Lett 581 (14), 2691-2696 (2007)
   PUBMED   17531978
REFERENCE   3  (bases 1 to 752)
  AUTHORS   Kawamura,A., Koshida,S., Hijikata,H., Ohbayashi,A., Kondoh,H. and
            Takada,S.
  TITLE     Groucho-associated transcriptional repressor ripply1 is required
            for proper transition from the presomitic mesoderm to somites
  JOURNAL   Dev Cell 9 (6), 735-744 (2005)
   PUBMED   16326386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001398742.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI145486.1, BF545907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               JAXUCZ010000008.1  96854729-96855138
            411-475             JAXUCZ010000008.1  96855469-96855533
            476-752             JAXUCZ010000008.1  96858684-96858960
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..752
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="ripply transcriptional repressor 2"
                     /db_xref="GeneID:363111"
                     /db_xref="RGD:1308746"
     exon            1..410
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..632
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ripply2 homolog"
                     /codon_start=1
                     /product="protein ripply2 isoform 1"
                     /protein_id="NP_001385671.1"
                     /db_xref="GeneID:363111"
                     /db_xref="RGD:1308746"
                     /translation="MDTTESAESAHSPARSPSRSRCPPPAQPGYLSAWIHPRAFSTLA
                     LCLPTTEPEDRLAPAQPRAPSTSALAPYPSPLPLPVPSALAKFELSRVARLTFFVRGL
                     RLLSCRSEGFWRPWVRTPGEKEELAEPRAAEVLPSGPGMIEASRKLLQYQHPVRLFWP
                     KSKCYDYLYQEAETLLKNFPIQATISFYEDSDSEDDVEGLACENQSN"
     misc_feature    342..596
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="Transcription Regulator; Region: Ripply; pfam14998"
                     /db_xref="CDD:464433"
     misc_feature    342..596
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="Transcription Regulator; Region: Ripply; pfam14998"
                     /db_xref="CDD:464433"
     exon            411..475
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
     exon            476..752
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccggccat ggataccacg gagagcgccg agagcgcgca cagcccagca cgttcgccct
       61 cgcgcagccg ctgcccgccg cccgcgcagc ccgggtacct atcagcctgg atccatcccc
      121 gcgcattctc caccctcgcc ctgtgcctgc cgaccacgga gcccgaggac cgcctggccc
      181 cggctcagcc ccgtgcaccc tctacctccg ccctcgcccc gtacccgtcg cccttgcctt
      241 tgcccgtgcc cagtgcccta gctaagttcg agttgagtcg ggtggctcgg ctcacgttct
      301 ttgtgcgcgg cttgcgcttg ctatcctgca ggtccgaggg cttctggaga ccgtgggtta
      361 gaactcctgg cgagaaagag gagctggcgg aacctcgtgc tgcagaggtg ttgcccagcg
      421 gcccgggaat gattgaagct tccaggaagc ttttgcaata ccaacaccct gtcagactat
      481 tctggcccaa gtccaagtgt tacgactact tataccaaga agcagaaact cttctgaaaa
      541 attttccaat tcaagctaca atttcgtttt atgaagactc tgatagtgaa gatgacgtag
      601 aggggctggc ctgtgaaaac caatctaatt agttccttct gttgacaatt gagctgggta
      661 gaatctgaat tttgtacata aatgtaccat aactttttaa aactaattta tttgtatata
      721 cgttattaat aaaatatttt gtaataacta ta
//
LOCUS       NM_001436524            4268 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 5, mRNA.
ACCESSION   NM_001436524 XM_006242947
VERSION     NM_001436524.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4268)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4268)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4268)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4268)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4268)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4268)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4268)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4268)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4268)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4268)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006242947.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1653721.1,
                                           SRR26360194.1373194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1057           JAXUCZ010000008.1  57051767-57051799
            1058-1189           JAXUCZ010000008.1  57070067-57070198
            1190-4268           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4268
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1308
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 5 precursor"
                     /protein_id="NP_001423453.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DTTATTEPAVHDSRAGEEGAIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTY
                     FTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1162..1218
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1162..1218
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1057
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1189
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..4268
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgacacca cggcgacgac agaaccagca gttcacgatt ctcgagcagg tgaagagggc
     1081 gccattgggg cagtggacca cgcggtgatt ggcggcgtcg tagccgtggt ggtgtttgcc
     1141 atgctatgtt tgctcatcat tctgggccgc tattttgcca gacataaagg tacatacttc
     1201 actcatgaag ccaaaggagc cgatgacgca gcagacgcag acacagctat aatcaatgca
     1261 gaaggaggac agaacaactc cgaagaaaag aaagagtact tcatctagat cagccttttt
     1321 gttccaatga ggtgtccaac gggcctgctt agatgataaa gagacagtga tactggaact
     1381 ttggagaagc tcgtgtggtt ttttttttat gagtgggtgg aaagatgcga gactgggaag
     1441 gcttgggatt tgcaatgtaa aaacaaagac aaaaaatgtt ctttgaaagt acgctctgct
     1501 gtttgacacc tctttttaat ctggttttaa tttggtttgg gttttggtgt tttcgtttct
     1561 atttcctcct accaagtcaa acttgggtac ttggatttgg tttcggtaga ttgcagaaaa
     1621 ttctgtgcct tgtttttcat tcgtttgttg tgtttctttc cccttgccct ttttgtgcat
     1681 ttatttttcc caaaatcaaa tttgtttttc cccccctccc aaacctccca ttttttggaa
     1741 ttgacctgct gggattccta agattccccc ccccacccca tttctgattt ctttgtttgt
     1801 gttgacggtg actgctttct gttccaaatt cagtttcata aaaggaaaac cagcacagtt
     1861 tagatttcat agttcagaat ttagtgtctc catgatgcat ccttctctgt tgtcgtaaag
     1921 atttgggtga actaaaaaaa aaaaagaaaa aaagaaaaaa aaaagaaaac aatgaaaact
     1981 ctttgctgct gcccatgtct taaatactta gagcagcgaa gactagaaac gtagactgtg
     2041 acccagaagc tgtcgtctgc tgtggatctt cattactgta cagggttatc tgcaagtgag
     2101 gtgtgtcgca atgagattga atttgtcgtt aattctttat ctgtaggcgg ctcagtatag
     2161 attaccccac gctgtgcaga acgggggggg gggggttgtt ttttttgttt tttttttttt
     2221 tttttttgga gtggaaaggt ctcctccttc ctcgttgccc taaacagatc cgacaggtga
     2281 ggtctgtccg ttttatgtaa gtggacaaat ttgagatgcc acaggagggg aggcagggag
     2341 ggggaacgac agttctgctc tggttatttc tactctggac aatttcatcc acctttccca
     2401 attggcctta ctgctcgctg acgtgcagga gagagcaagt ccatgtgttg tgtgagtgac
     2461 tgaaggggac agaatttgtt taggtttttt tccccacttt tgtttttgct ttgggttttt
     2521 ttcccctttg tgcttattaa ggaaggcagt gggatgtgtc ctgtatgtac tgtatattac
     2581 agacaccgtc ctgctgggat ttccacctcc agtccctggc tctgctctca ttccttcaga
     2641 tttggcttga caaaggcagg aggtacaaaa gaagggccgg cattgttctc gaaaggtcag
     2701 agccaaggtg gagaagcagc atgtagagat tttcagttac ttaatcaaaa ctcaaaatgt
     2761 gagtgtttct atctttcctg cactagccct ggcctctttc ctcagcctta agaaccatct
     2821 gccaagaact cctcatctcg catgatggca gccatagtgc atagcaacta aaataagttt
     2881 ccgtgaacat atcttacacc ggagcctggg ggaaggtaga ggagtggagg aaccatttgc
     2941 attctctgaa gctaggtagg ggtttgcaga agtgctgagg acatctagaa gtagttctga
     3001 aggacaaagc ctaaactatt accacatgtg ttggtaagct ccagactcca aaactgtccc
     3061 tctgggaaga cggcaccaga aaagatagag ctatctatat ataaatatat aaatatatat
     3121 tatataacat tttcagtcag tacttttgga ttttgcaagg tgcattttta ctcttgttac
     3181 attatgtgga aaacttatgc tgatttattt aaggggaaaa aagtgtcgac tctgttattt
     3241 gaaaggatat ttctttttct tgtcttcatt ttaacttctg atagaaccac tgcaatatga
     3301 gggccttttg ggaacggact ggtgtgtaaa agaaaattca tcatcgagca gtgttttgtt
     3361 aacccctctc ctgcccctag gcacttaacc aagaaaaaag ccacaaggaa catccctttt
     3421 tcaagaattt tataatgtgc atctattccg agcccttagc acccatcctg accatagtgt
     3481 gaccatatca aagggtgaca accagttagc atgtcgttga aagggttttt cagctgttct
     3541 ttttagaaaa aaaatataaa aaatattaaa aaaaactaaa aataagcaaa cacaaaaaaa
     3601 ctcccattgt tcacagaatt ggcatctcat tttcgggaca gcccatcttt ctgttttgac
     3661 aagtgtacag tagtgcggtg ttctgatgta actttatggc ttaagatgtt gacatgtctc
     3721 aggttcctgt gtttcgattg gtgtttttcc gtctcaggta gattgcaaag tgtaggcccc
     3781 acacattgga aaaataataa taataataat aaataataat aataataatt aaacaaagca
     3841 aaaacaggaa attacggatt ttagttgtat attggtttat gtatttttct taagtataca
     3901 gtgcactgtt tgaaatgtat tgttgagtat tactttgtac aggttgatca ctttttttag
     3961 agtgaagaaa gaacaaactt ggtttttttg tgttttttta aaggagtata aaataatgaa
     4021 ggatgtataa ttgatgccaa ataagcttgt tctttagtca cgatgacgtc ttgttttccc
     4081 tctaggccag ttctgtttct aaggtgtaca aggaccatgt tacagtgtaa gaaactccac
     4141 atccgtgtgt tccattcgca ttttgtatcg gttcatgtat accattttta caaaaagaaa
     4201 aaagaaaaaa aaaagaagta ctataaaata tctgtcttct taataaaaaa gattaatgtt
     4261 acaagtga
//
LOCUS       NM_001106830            3666 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus IQ motif containing H (Iqch), transcript variant
            4, mRNA.
ACCESSION   NM_001106830 XM_001075872 XM_236331
VERSION     NM_001106830.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced NM_001106830.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000008.1  72978476-72978591   c
            117-239             JAXUCZ010000008.1  72965283-72965405   c
            240-328             JAXUCZ010000008.1  72964734-72964822   c
            329-443             JAXUCZ010000008.1  72954872-72954986   c
            444-560             JAXUCZ010000008.1  72940310-72940426   c
            561-681             JAXUCZ010000008.1  72914785-72914905   c
            682-810             JAXUCZ010000008.1  72911713-72911841   c
            811-887             JAXUCZ010000008.1  72901990-72902066   c
            888-926             JAXUCZ010000008.1  72900132-72900170   c
            927-1478            JAXUCZ010000008.1  72891516-72892067   c
            1479-1545           JAXUCZ010000008.1  72890677-72890743   c
            1546-1629           JAXUCZ010000008.1  72879267-72879350   c
            1630-1805           JAXUCZ010000008.1  72875386-72875561   c
            1806-2078           JAXUCZ010000008.1  72866121-72866393   c
            2079-2270           JAXUCZ010000008.1  72861335-72861526   c
            2271-2391           JAXUCZ010000008.1  72848274-72848394   c
            2392-2678           JAXUCZ010000008.1  72845413-72845699   c
            2679-2849           JAXUCZ010000008.1  72819954-72820124   c
            2850-2972           JAXUCZ010000008.1  72811070-72811192   c
            2973-3034           JAXUCZ010000008.1  72795168-72795229   c
            3035-3143           JAXUCZ010000008.1  72791557-72791665   c
            3144-3666           JAXUCZ010000008.1  72787701-72788223   c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3666
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ motif containing H"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
     exon            1..116
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    6..8
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="upstream in-frame stop codon"
     CDS             66..3278
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="isoform 4 is encoded by transcript variant 4; IQ
                     domain-containing protein H"
                     /codon_start=1
                     /product="IQ domain-containing protein H isoform 4"
                     /protein_id="NP_001100300.1"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
                     /translation="MAQAQELNDPIGSILIQVHGDLHQLKEKLIQFSAEETRDPLDIQ
                     NLETAIQRTETGLKIHIERYLGIVNQEVIMTPVKSLDSPINSKWAIPTVIDQKSFIFP
                     MAPDKLWGLQKHRGSLPRGFTRAKPKVELNKKIMQDPENMHHRAAVNVSYGISLPRIK
                     QRKAHDKVRRVRKGSTISNLTVLPSSHRTDPHFIPIPVLQKDASKGILSMIERGLIPP
                     AARITFQNPPIKPQALPLHSFDEHRKVSITASFPIAHKPRLASEKVEESQQKQKAKGK
                     DKRSRGQPSRKSTRITTPSRIRRSPWDYILPVYNGSVDRAAPDFIAFKTRYKLIWGSI
                     FSFLEQIEKFLKDYAISEAKVRGKSLVSLLPEFELNNKLTKTDVLAVLENPLHIQMLL
                     NLPGQRFKGRDGRTEAAVKIQATWKSYKARTSFISYRQKKWASGVIALAWLLHCHKTR
                     LKRIVEESRQRHLDNFRIRAKHLAANWSRIRTSRRTIIHIPSLGYSQSVRKHISDLDI
                     EQNRQLGRLCDILDVNVNVIYVCSSPMNDELKLYYKKLLSLQAAVKSGYYGDRSDLQN
                     RFRIITPEAVNIFTKHHMCLATHLMYSPKAIKRIKNLIQGEEAYIVGGILHRDDLAVA
                     DMLNVPILASEPELVHLYSGKSGSKRIFDNANVPMPPGVYDIYTYQQLIEQLSQLVTD
                     NLGIRRWVFKMNMEFGGNGTAFCDIPSHLQCYKWVVKESNRFGPEDWKKKWAQESALM
                     KISEELAGVLAQHVQLVNEKQFPTWRKFLHMFLTQGGIIEAYPPADSITNLTVDMLIE
                     PDGEVRVLSMGDQFHADGPFISSGTTMPQTSVDPQVLNSLCLRIGNICKEKDVVGYFS
                     IDLVTFIDPSTLEQQVWTTGLNLSYSDQLAMTQLTLYLTNGYLNCSLSTLEVPRFKED
                     AEREKKRLSIQAELAPETSRYAVMSTQLKHDNLSLIFYYVFLQMCKAHGIGYDLEDRQ
                     GTVFILYESLKRYKLGMITIGVDLQGALMTFARNLFIIHQEISAPDMQGETNFKTTID
                     DIETILGVTEENKMIFAGEKRRKEEEESLYEPVEIYTKTV"
     misc_feature    1278..1361
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1278..1361
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     exon            117..239
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            329..443
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            682..810
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            811..887
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            888..926
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1478
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1545
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1629
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1805
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2078
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2270
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2391
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2678
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2849
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2972
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3034
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3143
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3666
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctagaa gcgctccgga gaaggccata cctccggagc caagcgcctt ctgcctgcct
       61 cagtcatggc tcaggcccag gagctcaacg accccattgg atccatccta atccaggtcc
      121 atggggacct ccatcagtta aaggagaaat taattcaatt ctcagctgag gagacaagag
      181 accctctaga cattcaaaat cttgagacag caattcaaag aactgaaacg gggttaaaga
      241 ttcacattga gaggtatctc ggaattgtaa accaggaggt gataatgact cctgtgaaga
      301 gcttagactc ccctatcaat tccaaatggg cgattccaac tgtaattgac cagaaatcct
      361 ttatttttcc catggctccc gataaacttt ggggacttca aaaacatcgc ggttcacttc
      421 cacgcggctt tacaagagca aagccaaaag tagagttgaa caagaagatc atgcaggacc
      481 ctgagaacat gcaccacaga gctgctgtaa atgtgagcta tgggatcagt ttgccacgta
      541 ttaaacagag gaaagcacat gataaggttc ggcgggtaag aaaagggtcc acgatctcca
      601 acctcacagt tctgccatcc agtcatcgca ctgaccccca ttttatcccc atacctgtct
      661 tgcaaaagga tgccagtaaa gggatcttaa gtatgatcga acgagggctg atccccccag
      721 cagcaaggat tacctttcag aatccaccca ttaaacccca agcacttcct ctgcatagct
      781 ttgatgagca tcggaaggta tcaataacag cctcctttcc gatagctcat aagccacgcc
      841 tggcttcaga aaaagtggag gagtctcaac agaaacagaa agccaaggga aaagacaaaa
      901 ggtcaagagg acaacccagt aggaagagca cgaggattac tacaccgtct aggattagga
      961 gatcaccatg ggattacatc ttgcctgttt acaacggctc tgtagacagg gcagccccag
     1021 actttatagc attcaaaaca cgttacaaat taatctgggg aagcattttt tctttcctgg
     1081 aacaaattga gaaatttctc aaggactatg caatatcaga agccaaagta agagggaaga
     1141 gtctggtgtc cctgcttcca gagtttgagc tgaacaacaa acttaccaaa actgacgttc
     1201 tggctgtgct agagaacccg ctccacatcc agatgctgct aaatcttcct ggacagaggt
     1261 tcaagggccg ggacggaagg acagaggctg ccgtcaagat ccaagccaca tggaaaagtt
     1321 ataaggcaag aacttccttc atttcttatc gccagaagaa gtgggcctcg ggagtgatcg
     1381 ccctggcatg gcttctacat tgccacaaaa caagactaaa gaggatagtg gaggaatctc
     1441 gacagagaca cctggataac ttccgaattc gagccaagca tctggcagcc aactggagtc
     1501 gcatcaggac ctccaggagg actattatcc atataccatc attaggatat tcccagtctg
     1561 tgcgaaaaca catatctgat ttggacatag agcagaacag gcagttgggg aggctgtgtg
     1621 acatcctaga tgtcaacgtc aatgtcatct acgtctgctc cagtcccatg aatgacgagt
     1681 taaagctgta ctacaaaaaa ctcctgagtc tgcaagcagc tgtcaaatcg ggctactatg
     1741 gggataggtc tgacctgcaa aacaggttca gaattatcac ccctgaagct gtaaacatct
     1801 tcactaaaca tcacatgtgc ctggctactc acctgatgta cagtcccaag gcaatcaaaa
     1861 gaataaaaaa tctcatccaa ggagaagagg cctacatcgt gggcgggatc ctccacagag
     1921 atgatttagc tgtggctgac atgttgaatg tacccatcct ggcctcagag cctgagctgg
     1981 ttcaccttta cagtggcaag tctggaagta aacggatctt tgataacgct aatgtgccaa
     2041 tgcctcctgg agtatatgac atctatactt accagcagct gatagaacaa ttgagtcagt
     2101 tggtgactga taacctggga atccgacgct gggtctttaa aatgaacatg gaatttggag
     2161 gaaatgggac agcattttgc gacatccctt cccatctaca gtgctacaaa tgggtggtga
     2221 aggagagtaa cagattcggc cctgaggact ggaagaagaa gtgggcacaa gagtcagctc
     2281 tgatgaagat ctccgaggag ctggcgggcg ttttagcaca gcacgtacag ctagtcaatg
     2341 agaaacagtt cccgacatgg agaaaattcc tccacatgtt tctcactcaa ggtggcatca
     2401 ttgaagcata cccacctgca gacagcatca ccaacctcac cgtagacatg ttgatagagc
     2461 ctgacggaga agtcagagtg ctgtcaatgg gggaccagtt tcatgctgat ggccccttta
     2521 tttcttctgg taccaccatg cctcagactt cagtggatcc ccaagttctc aattctttgt
     2581 gcctccgaat tggaaatatc tgcaaagaga aagatgtggt tggttatttt tctatagatc
     2641 tggtgacttt tattgatcca agcaccttag agcagcaggt atggacaaca ggcctcaacc
     2701 tctcatacag tgaccagcta gccatgacgc agctcaccct gtacctgaca aatggttatc
     2761 tgaattgtag tctgagcacc ctggaagtgc cccgttttaa agaagatgca gaaagggaaa
     2821 agaaacgtct gagcatccag gcagagctgg ccccagaaac cagtcgctat gcagtgatgt
     2881 ccacacagct gaagcacgac aatctctcac tcatcttcta ttatgttttt ctccagatgt
     2941 gtaaggccca tggcatcggc tatgaccttg aggacagaca aggaactgtt tttatattat
     3001 atgaatctct gaagagatac aagttgggca tgataacaat cggtgtggat ctccaggggg
     3061 ccctcatgac ctttgctcgc aatctcttca tcatccatca agaaatatca gcacctgata
     3121 tgcaaggcga gaccaatttt aagactacca ttgatgatat tgaaaccatt ttaggagtaa
     3181 cagaagaaaa taaaatgata tttgcaggag aaaaacggcg caaagaggag gaagagagcc
     3241 tgtatgagcc tgttgagata tacacaaaaa cagtatgact ttggatacct gtctaaagcg
     3301 agaaaaaagg tttgctttgt aattaatgta aaagtgagga agttagtttg ctttgtttgc
     3361 caagagataa atcagaacaa attgtaacat aatagtcttt aaaatctttg cttattttcc
     3421 agtgttattt tactcattaa ggttaaacct accggtgttt tcattgtgag tgctaagaat
     3481 cccttcctcc tccccaaaac aaagaagcca gaggaaggct ttggcccact actgctccac
     3541 ttcttttctc ctgcttccaa aagccactta gggtcttcat ttaaaatacc aaataaacca
     3601 gagtgatcac ttgtcaaaac acaaatgtcc tcttttccca aaataaatga aatcagtttt
     3661 aaatga
//
LOCUS       NM_001436463            3181 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus RB-associated KRAB zinc finger (Rbak), transcript
            variant 2, mRNA.
ACCESSION   NM_001436463 XM_006248867
VERSION     NM_001436463.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3181)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006248867.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.56417.1,
                                           SRR26643429.42461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000012.1  16488954-16489160
            208-269             JAXUCZ010000012.1  16490266-16490327
            270-396             JAXUCZ010000012.1  16498303-16498429
            397-492             JAXUCZ010000012.1  16498756-16498851
            493-3181            JAXUCZ010000012.1  16499835-16502523
FEATURES             Location/Qualifiers
     source          1..3181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3181
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="RB-associated KRAB zinc finger"
                     /db_xref="GeneID:288489"
                     /db_xref="RGD:1562875"
     exon            1..207
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            208..269
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2390
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="RB-associated KRAB repressor"
                     /codon_start=1
                     /product="RB-associated KRAB zinc finger protein"
                     /protein_id="NP_001423392.1"
                     /db_xref="GeneID:288489"
                     /db_xref="RGD:1562875"
                     /translation="MSISKGPLSFKDVAVAFSQEEWQQLDSEERTTYRDVMLETYSNL
                     VSVGYDVTKPNVIIKLEQGEEPWTVEGDRHAKRHLEIKKVDDPREGIQENGEKHLQCG
                     DDLHSWRAEKGDEFDEACTLEPPLISPSSGAHSCVSCGKTLESVTELICSDGSYAVEK
                     PDKCFECGKGYRENPEDLNQSEGNSSERDESILQKITILEKPFDYECLEALDRESVFM
                     AHERAYMGEKPYEWNGSGPDFIQISDFSTYHRSQVEMKPFECTQCGKSFCKKSKFIIH
                     QRAHTGEKPYACGVCGKSFSQKGTLTVHRRSHLEEKPYKCDECGKTFCQKLHLTQHQR
                     THSGEKPYECSECGKTFCQKTHLTLHQRNHSGERPYPCSECGKSFSRKSALNDHQRTH
                     TGEKLYTCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLE
                     EKPYECTECGKTFNLNSAFTRHRKAHAEERVQECGECGKPSRLQYLPDHADGLGEKHH
                     GCNECGKTFLENSAFSRHQPVPEGEKTYECNICGKVFSDLSCYTVHYRGHSEEKPFGC
                     SECGKTFSHNSSLFRHQRVHTGEKPYECYECGKFFSQKSYLTIHHRIHSGEKPYECSK
                     CGKVFSRMSNLTVHYRSHSGEKPYECNECGKVFSQKSYLTVHYRTHSGEKPYECNECG
                     KKFHHRSAFNSHQRIHKRGTINVLNVENL"
     misc_feature    276..458
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    276..458
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    1032..1094
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1032..1094
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1116..1178
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1116..1178
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1194..1262
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1194..1262
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1200..1262
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1200..1262
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1215..1217,1221..1223,1227..1229,1233..1238,
                     1245..1250,1257..1259,1299..1301,1305..1307,1317..1322,
                     1329..1334,1341..1343,1383..1385,1389..1391,1395..1397,
                     1401..1406,1413..1418,1425..1427)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1215..1217,1221..1223,1227..1229,1233..1238,
                     1245..1250,1257..1259,1299..1301,1305..1307,1317..1322,
                     1329..1334,1341..1343,1383..1385,1389..1391,1395..1397,
                     1401..1406,1413..1418,1425..1427)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1272..2351
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1272..2351
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1284..1346
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1284..1346
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1368..1430
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1368..1430
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1452..1514
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1452..1514
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1536..1598
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1536..1598
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1620..1682
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1620..1682
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1782..1844
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1782..1844
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1866..1928
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1866..1928
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1950..2012
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1950..2012
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2034..2096
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2034..2096
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2118..2180
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2118..2180
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2133..2135,2139..2141,2145..2147,2151..2156,
                     2163..2168,2175..2177,2217..2219,2223..2225,2235..2240,
                     2247..2252,2259..2261,2301..2303,2307..2309,2313..2315,
                     2319..2324,2331..2336,2343..2345)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2133..2135,2139..2141,2145..2147,2151..2156,
                     2163..2168,2175..2177,2217..2219,2223..2225,2235..2240,
                     2247..2252,2259..2261,2301..2303,2307..2309,2313..2315,
                     2319..2324,2331..2336,2343..2345)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2202..2264
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2202..2264
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2286..2348
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2286..2348
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            270..396
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            397..492
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            493..3181
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcgccgc tgtgactcct gcaggtccgt cgtcgaggct accttccttc ccacagcttt
       61 tgcacccgct aagctggagt cgccgagcct gcgggaacga gaccggagct tccggggcgg
      121 cagcgaacag actcagctgt gctggcctgg gaggcctaga gggagctcgg cgcggaggac
      181 gacagtggcg gcggggccgt ctgctggcag gtcagtcgtc agtgttgtct acggtttccc
      241 aagaggagca aaagatgagc atatcaaagg gcccactgtc attcaaggat gtggctgtgg
      301 ccttctccca ggaggagtgg cagcagctgg actctgagga gaggacgacc taccgggatg
      361 tgatgctgga gacctacagc aacctcgtct ccgtggggta tgatgtcacc aagccaaacg
      421 tgattattaa gttggaacag ggagaagaac cctggacagt ggaaggtgac cgccatgcta
      481 agaggcattt ggaaatcaaa aaagttgatg accccagaga aggaatccag gaaaatggcg
      541 agaaacatct gcagtgcggt gatgatctcc acagctggag agcggagaag ggggacgagt
      601 ttgatgaagc ctgcacccta gaaccacccc tcatttcccc cagctcaggc gctcacagct
      661 gtgtctcctg tgggaagact ttggaatctg ttacagaact gatttgcagt gatggaagct
      721 atgcagtaga gaagcccgac aagtgttttg agtgtgggaa agggtacaga gaaaaccctg
      781 aggaccttaa ccaaagtgag ggtaactctt ctgaacgtga cgaaagtatt ctgcagaaaa
      841 tcaccatttt ggagaaaccc tttgactatg agtgcttgga agccttagac agggaaagtg
      901 ttttcatggc tcatgagaga gcttacatgg gggagaagcc ctatgaatgg aacggttctg
      961 gaccagactt catccagata tcagacttca gtacgtatca cagatcacaa gtggaaatga
     1021 agcccttcga atgtacgcag tgtgggaagt ccttctgtaa gaagtccaaa ttcatcatcc
     1081 atcagagagc gcacacagga gagaaaccgt atgcttgcgg tgtgtgtgga aagtccttta
     1141 gtcaaaaggg gaccctcact gtacatcgga ggtcacactt agaggagaag ccctataagt
     1201 gcgatgagtg tgggaagacc ttctgtcaga agttacacct cacacagcac cagagaactc
     1261 actcaggaga gaagccctac gaatgtagcg agtgcgggaa gaccttctgc cagaagacgc
     1321 accttactct acaccagagg aatcattcag gggagaggcc ctatccgtgt agtgaatgcg
     1381 ggaaatcctt ctcccggaag tctgccctca atgaccatca gagaacacac acaggagaga
     1441 agctctacac gtgtaacgag tgtggtaagt cctactaccg gaagtccacc ctcatcacgc
     1501 accagagaac acacacgggg gagaagccct atcagtgtag tgagtgtggg aagttcttct
     1561 ctcgcgtgtc gtacctcacc atacactata ggagccattt agaagagaaa ccttatgagt
     1621 gtacagaatg tgggaaaacc ttcaatctaa actccgcctt caccaggcac cggaaggccc
     1681 atgcagaaga gagagtgcag gagtgcggtg agtgtgggaa gccgtcccgg ctgcagtatc
     1741 tccctgatca cgctgatggc ctaggagaga agcaccacgg gtgtaatgag tgtgggaaga
     1801 ccttccttga aaactcagcc ttcagcaggc accagcccgt tcccgaaggg gagaaaactt
     1861 acgagtgtaa catatgcggg aaggtgttct ctgacctgtc gtgctacact gtgcattaca
     1921 gaggtcattc agaagagaaa ccctttggct gcagcgagtg tgggaaaacc ttctctcata
     1981 attcatccct cttcagacat cagagagtac acacaggcga gaagccgtac gagtgttacg
     2041 agtgtggcaa gttcttctcg cagaagtcct acctcactat ccatcacagg atccattcag
     2101 gagagaagcc gtacgagtgt agcaagtgtg gcaaagtgtt ctctcggatg tcgaacctca
     2161 ccgtccacta ccgaagccat tcaggagaga agccctatga atgtaatgag tgtggaaaag
     2221 tcttctccca gaagtcgtac ctcactgttc attaccggac tcattcagga gagaagcctt
     2281 atgaatgtaa cgaatgtggg aaaaaattcc accacagatc agccttcaat agccatcaga
     2341 gaattcataa aagagggact ataaatgtac ttaatgtaga aaatctctga cgtctcaatt
     2401 tttaaaaaga catatggtta tagtgaacat tgggagtcca ataggtagtc aagggtgccc
     2461 ccccaaactt ttaatatatg tggtgctggg aactgaatat gggccctttg catgctatag
     2521 aaattctgca ctgagctgga ctgcagtgac tcacgagttg agcacccctg ctcttaaaga
     2581 gtgtgaagtc ctaaaacaaa atccatttta acctgaattt tcagagcaga atctgtaaag
     2641 attgggcaag aagcaaaccg tttatgggac actaggtaat ttttacagga gtgaaacttc
     2701 gaaagtattt aatatttatt ttttatttaa attgtattta catatcaggg agcgttgccg
     2761 agaactgtca gccgatgagt ataactcacc ttggacacat acgctaaaag ccatatttct
     2821 gatgtcagac caggtgtcta tagacaggat gcaagaagcc gtcagctctg agcaaagtta
     2881 tgaaatgaaa ttataaagct agcgcttggc cacgaggatg actaaaccac ggcacctctg
     2941 ctgttctaga agtcgagcag ccattctatg caatgtttgc catctccgcc tcgaacgatt
     3001 ggtggaaacc tggtatccag gattagcaac gcctgttaca gtgggtccat tggtgggata
     3061 tgctatgtga tcgggaagta catagttttc taggtcactg cttgccagga gagcggtttt
     3121 gtaaaaaatt ttcaactgga attgagcaaa aaatttttta aaatactatt ttgataaact
     3181 a
//
LOCUS       NM_001436394            1956 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus platelet derived growth factor subunit A (Pdgfa),
            transcript variant 2, mRNA.
ACCESSION   NM_001436394 XM_039089106
VERSION     NM_001436394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Rashid,F.N., Clayton,Z.E., Ogawa,M., Perdomo,J., Hume,R.D.,
            Kizana,E. and Chong,J.J.H.
  TITLE     Platelet derived growth factor-A (Pdgf-a) gene transfer modulates
            scar composition and improves left ventricular function after
            myocardial infarction
  JOURNAL   Int J Cardiol 341, 24-30 (2021)
   PUBMED   34265313
  REMARK    GeneRIF: Platelet derived growth factor-A (Pdgf-a) gene transfer
            modulates scar composition and improves left ventricular function
            after myocardial infarction.
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Connolly,N.P., Stokum,J.A., Schneider,C.S., Ozawa,T., Xu,S.,
            Galisteo,R., Castellani,R.J., Kim,A.J., Simard,J.M., Winkles,J.A.,
            Holland,E.C. and Woodworth,G.F.
  TITLE     Genetically engineered rat gliomas: PDGF-driven tumor initiation
            and progression in tv-a transgenic rats recreate key features of
            human brain cancer
  JOURNAL   PLoS One 12 (3), e0174557 (2017)
   PUBMED   28358926
  REMARK    GeneRIF: an Ntv-a transgenic rat colony was established and used to
            study glial brain tumors driven by two well-characterized oncogenic
            gene transformations, PDGFA overexpression and p53 depletion.
            Combined PDGFA and p53 alterations resulted in large, heterogeneous
            tumors in all affected animals
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Shepherd,J.A., Stamper,E., Matheson,P.J., Galganski,L.,
            Garrison,R.N., Madden,K. and Downard,C.D.
  TITLE     Alterations in platelet-derived growth factor expression in the
            pathophysiology of necrotizing enterocolitis
  JOURNAL   J Surg Res 198 (2), 377-383 (2015)
   PUBMED   25899145
  REMARK    GeneRIF: expression altered in experimental Necrotizing
            enterocolitis
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Ha,J.M., Yun,S.J., Kim,Y.W., Jin,S.Y., Lee,H.S., Song,S.H.,
            Shin,H.K. and Bae,S.S.
  TITLE     Platelet-derived growth factor regulates vascular smooth muscle
            phenotype via mammalian target of rapamycin complex 1
  JOURNAL   Biochem Biophys Res Commun 464 (1), 57-62 (2015)
   PUBMED   26032503
  REMARK    GeneRIF: PDGF regulates vascular smooth muscle phenotype via
            mammalian target of rapamycin complex 1.
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Bryckaert,M.C., Rendu,F., Tobelem,G. and Wasteson,A.
  TITLE     Collagen-induced binding to human platelets of platelet-derived
            growth factor leading to inhibition of P43 and P20 phosphorylation
  JOURNAL   J Biol Chem 264 (8), 4336-4341 (1989)
   PUBMED   2538439
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W.,
            Kraus,M., Pierce,J. and Aaronson,S.
  TITLE     Isolation of a novel receptor cDNA establishes the existence of two
            PDGF receptor genes
  JOURNAL   Science 243 (4892), 800-804 (1989)
   PUBMED   2536956
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Escobedo,J.A., Navankasatussas,S., Cousens,L.S., Coughlin,S.R.,
            Bell,G.I. and Williams,L.T.
  TITLE     A common PDGF receptor is activated by homodimeric A and B forms of
            PDGF
  JOURNAL   Science 240 (4858), 1532-1534 (1988)
   PUBMED   2836953
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Womer,R.B., Frick,K., Mitchell,C.D., Ross,A.H., Bishayee,S. and
            Scher,C.D.
  TITLE     PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma
            cells but does not stimulate cell replication
  JOURNAL   J Cell Physiol 132 (1), 65-72 (1987)
   PUBMED   2439522
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Heldin,C.H., Westermark,B. and Wasteson,A.
  TITLE     Platelet-derived growth factor: purification and partial
            characterization
  JOURNAL   Proc Natl Acad Sci U S A 76 (8), 3722-3726 (1979)
   PUBMED   291037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 11, 2025 this sequence version replaced XM_039089106.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2193893.1, CF111796.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000012.1  20761808-20762043
            237-333             JAXUCZ010000012.1  20763365-20763461
            334-438             JAXUCZ010000012.1  20768458-20768562
            439-626             JAXUCZ010000012.1  20770718-20770905
            627-753             JAXUCZ010000012.1  20777995-20778121
            754-1956            JAXUCZ010000012.1  20780032-20781234
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1956
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="platelet derived growth factor subunit A"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
     exon            1..236
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..764
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; PDGF subunit A; Platelet-derived growth factor
                     A chain; platelet derived growth factor, alpha;
                     platelet-derived growth factor alpha polypeptide"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit A isoform
                     2 precursor"
                     /protein_id="NP_001423323.1"
                     /db_xref="GeneID:25266"
                     /db_xref="RGD:3282"
                     /translation="MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDL
                     QRLLEIDSVGAEDALETNLRAHGSHTVKHVPEKRPVPIRRKRSIEEAIPAVCKTRTVI
                     YEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRK
                     KPKLKEVQVRLEEHLECACATSNLNPDHREEETDVR"
     sig_peptide     174..233
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    234..458
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     misc_feature    234..458
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived growth factor, N terminal region;
                     Region: PDGF_N; pfam04692"
                     /db_xref="CDD:461394"
     misc_feature    453..716
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    453..716
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(453..464,570..572,576..587,630..641)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(453..464,570..572,576..587,630..641)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(459..461,558..560,570..572,591..593,702..704,
                     708..710)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(459..461,558..560,570..572,591..593,702..704,
                     708..710)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(540..542,567..569)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(540..542,567..569)
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    573..575
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P28576.2); glycosylation site"
     misc_feature    645..659
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /note="propagated from UniProtKB/Swiss-Prot (P28576.2);
                     Region: Receptor binding site. /evidence=ECO:0000255"
     exon            237..333
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            334..438
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            439..626
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            627..753
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1956
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1; PDGFACP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcgcag ctcgcgccga gcgcgctccg caggctccct gctctccgcg ccaccctcct
       61 ccgggccgcg ctccctgagg gatggtactg aatttcgccg ccacaggagc ccggctggag
      121 cgcccgcccc gcggcctcgc ctccctgccg agcttccagc gcctcgggac gcgatgagga
      181 cctgggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgccctg gccgaggaag
      241 ccgagatacc ccgggagttg atcgagcgac tggctcgaag tcagatccac agcatccggg
      301 acctccagcg actcttggag atagactccg taggggctga ggatgccttg gagacaaacc
      361 tgagagccca tgggtcccac actgttaagc atgtgccgga gaagcggcct gtgcccatcc
      421 gcaggaagag aagtattgag gaagccattc ccgcagtttg caagaccagg acggtcattt
      481 acgagatacc tcggagccag gtggacccca catcggccaa cttcttgatc tggcccccat
      541 gtgtggaggt gaagcgctgc actggctgct gtaacaccag cagcgtcaag tgccagccct
      601 caagggtcca ccaccgcagt gtcaaggtgg ccaaagtgga gtatgtcagg aagaagccaa
      661 aattgaaaga ggtccaggtg aggttagagg agcacctgga gtgcgcatgc gcgacctcca
      721 acctgaaccc agaccatcgg gaggaggaga cggatgtgag gtgagatgag ctggctgccc
      781 tctcccggga cacggatgta cgtggcgtgt gacattcctg aacatactat gtatggtgct
      841 tcattgccaa tgtgcgtgca gtctttgttc tcctccgtga aaaactgtgt ccgaggacaa
      901 agagacagtg tccgtttgtt cagtgtgaca tcaaagcaag tactgtagca ctcggagaga
      961 cagtgagaaa gcttccttgt cacagagagc gaaaacaaaa ccacaaaaaa gaaaaaaaaa
     1021 aaaaacaaaa aaattaaaaa agaaaaaaaa aaaacaaaac cacacccaac aacaaaaaaa
     1081 ccccaccaga agaaacaaaa aaagactgaa gcgggcaaca gaagggccgc cctgcaggac
     1141 tgaccctcga gtggtggctg atgttggcca ccaccctgga ttctgcccgt gggcacaggt
     1201 gcttttcgcc aaggacgccc agaatgctac ctgccagctc tactaggtac aggaactgaa
     1261 cgaatgggag aagcccgcgg gcctggaagc caccgcctgg actgagtctg cctgggaact
     1321 tcctgatggc cttacgtgga atttcttttt tcttatcttt ttcttttttt ttttttcctt
     1381 tccttttatt tttttacacc atgaagtaat tgagcttctc ctttttattc tctgcctagc
     1441 cttttttttt tttttttttt aaatctcttg gatgacattt tcgttgataa catgcacgag
     1501 gctgctgtaa gttgggacag tgagacggtt attttttttt tcctagccaa actaatgagg
     1561 tgtattaaaa taaataccta cctatacatc atttccgatg cgcctctgcc ttcctttaac
     1621 atcttctagc ttaggtcatt tgagagaact atgagaatcg ctcagttttg ggtctccctc
     1681 cacccctagg gaccaccctc cattgctaaa cggcttctgc ggcagtgtgg aaactcgact
     1741 aagattattt tatagtaagc tgttgggttt cactgttaac cagaactgtg tgtgtgtgtg
     1801 tgtggtttcc ttgttttggt ttggttttgt aaaggtgaac tttgtatttt taatattatc
     1861 agtttatata cctgagagcc tgctatatat atattttttt tattttgaac taaaaggaga
     1921 aaaaaaaatc aacgaactta atgcacatca gatgca
//
LOCUS       NM_001436397           11272 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus myosin VA (Myo5a), transcript variant 1, mRNA.
ACCESSION   NM_001436397 XM_039080847
VERSION     NM_001436397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11272)
  AUTHORS   Canclini,L., Cal,K., Bardier,C., Ruiz,P., Mercer,J.A. and
            Calliari,A.
  TITLE     Calcium triggers the dissociation of myosin-Va from ribosomes in
            ribonucleoprotein complexes
  JOURNAL   FEBS Lett 594 (14), 2311-2321 (2020)
   PUBMED   32412091
  REMARK    GeneRIF: Calcium triggers the dissociation of myosin-Va from
            ribosomes in ribonucleoprotein complexes.
REFERENCE   2  (bases 1 to 11272)
  AUTHORS   Maschi,D., Gramlich,M.W. and Klyachko,V.A.
  TITLE     Myosin V functions as a vesicle tether at the plasma membrane to
            control neurotransmitter release in central synapses
  JOURNAL   Elife 7, e39440 (2018)
   PUBMED   30320552
  REMARK    GeneRIF: myosin V acts as a vesicle tether at the plasma membrane,
            rather than a motor transporting vesicles to the release sites, or
            directly regulating vesicle exocytosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11272)
  AUTHORS   Landrock,K.K., Sullivan,P., Martini-Stoica,H., Goldstein,D.S.,
            Graham,B.H., Yamamoto,S., Bellen,H.J., Gibbs,R.A., Chen,R.,
            D'Amelio,M. and Stoica,G.
  TITLE     Pleiotropic neuropathological and biochemical alterations
            associated with Myo5a mutation in a rat Model
  JOURNAL   Brain Res 1679, 155-170 (2018)
   PUBMED   29217155
  REMARK    GeneRIF: This study identified in vivo neuropathological and
            biochemical alterative changes involved in the pathogenesis of a
            spontaneous autosomal recessive movement disorder in a mutant Myo5a
            juvenile rat model.
REFERENCE   4  (bases 1 to 11272)
  AUTHORS   Guatteo,E., Rizzo,F.R., Federici,M., Cordella,A., Ledonne,A.,
            Latini,L., Nobili,A., Viscomi,M.T., Biamonte,F., Landrock,K.K.,
            Martini,A., Aversa,D., Schepisi,C., D'Amelio,M., Berretta,N. and
            Mercuri,N.B.
  TITLE     Functional alterations of the dopaminergic and glutamatergic
            systems in spontaneous alpha-synuclein overexpressing rats
  JOURNAL   Exp Neurol 287 (Pt 1), 21-33 (2017)
   PUBMED   27771352
REFERENCE   5  (bases 1 to 11272)
  AUTHORS   Ultanir,S.K., Yadav,S., Hertz,N.T., Oses-Prieto,J.A., Claxton,S.,
            Burlingame,A.L., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in
            promoting spine synapse development
  JOURNAL   Neuron 84 (5), 968-982 (2014)
   PUBMED   25456499
REFERENCE   6  (bases 1 to 11272)
  AUTHORS   Opartkiattikul,N., Funahara,Y., Fucharoen,S. and Talalak,P.
  TITLE     Increase in spontaneous platelet aggregation in
            beta-thalassemia/hemoglobin E disease: a consequence of splenectomy
  JOURNAL   Southeast Asian J Trop Med Public Health 23 Suppl 2, 36-41 (1992)
   PUBMED   1298991
REFERENCE   7  (bases 1 to 11272)
  AUTHORS   Mercer,J.A., Seperack,P.K., Strobel,M.C., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Novel myosin heavy chain encoded by murine dilute coat colour locus
  JOURNAL   Nature 349 (6311), 709-713 (1991)
   PUBMED   1996138
  REMARK    Erratum:[Nature 1991 Aug 8;352(6335):547]
REFERENCE   8  (bases 1 to 11272)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (bases 1 to 11272)
  AUTHORS   Moore,K.J., Seperack,P.K., Strobel,M.C., Swing,D.A., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     Dilute suppressor dsu acts semidominantly to suppress the coat
            color phenotype of a deletion mutation, dl20J, of the murine dilute
            locus
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8131-8135 (1988)
   PUBMED   3141922
REFERENCE   10 (bases 1 to 11272)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_039080847.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000008.1  84692923-84693008
            87-197              JAXUCZ010000008.1  84737211-84737321
            198-369             JAXUCZ010000008.1  84741640-84741811
            370-514             JAXUCZ010000008.1  84743618-84743762
            515-671             JAXUCZ010000008.1  84751759-84751915
            672-815             JAXUCZ010000008.1  84758095-84758238
            816-897             JAXUCZ010000008.1  84762533-84762614
            898-1005            JAXUCZ010000008.1  84763372-84763479
            1006-1112           JAXUCZ010000008.1  84766041-84766147
            1113-1378           JAXUCZ010000008.1  84768764-84769029
            1379-1460           JAXUCZ010000008.1  84770141-84770222
            1461-1601           JAXUCZ010000008.1  84773525-84773665
            1602-1727           JAXUCZ010000008.1  84775345-84775470
            1728-1811           JAXUCZ010000008.1  84777568-84777651
            1812-1973           JAXUCZ010000008.1  84781218-84781379
            1974-2071           JAXUCZ010000008.1  84782283-84782380
            2072-2158           JAXUCZ010000008.1  84784944-84785030
            2159-2267           JAXUCZ010000008.1  84785110-84785218
            2268-2479           JAXUCZ010000008.1  84790157-84790368
            2480-2636           JAXUCZ010000008.1  84791136-84791292
            2637-2876           JAXUCZ010000008.1  84793560-84793799
            2877-3125           JAXUCZ010000008.1  84795682-84795930
            3126-3219           JAXUCZ010000008.1  84798194-84798287
            3220-3368           JAXUCZ010000008.1  84802847-84802995
            3369-3482           JAXUCZ010000008.1  84805130-84805243
            3483-3626           JAXUCZ010000008.1  84811772-84811915
            3627-3680           JAXUCZ010000008.1  84812131-84812184
            3681-3908           JAXUCZ010000008.1  84813217-84813444
            3909-4009           JAXUCZ010000008.1  84816530-84816630
            4010-4090           JAXUCZ010000008.1  84818936-84819016
            4091-4289           JAXUCZ010000008.1  84820462-84820660
            4290-4364           JAXUCZ010000008.1  84822753-84822827
            4365-4458           JAXUCZ010000008.1  84824205-84824298
            4459-4605           JAXUCZ010000008.1  84838277-84838423
            4606-4760           JAXUCZ010000008.1  84840700-84840854
            4761-4850           JAXUCZ010000008.1  84846002-84846091
            4851-5001           JAXUCZ010000008.1  84847640-84847790
            5002-5284           JAXUCZ010000008.1  84849736-84850018
            5285-5459           JAXUCZ010000008.1  84852044-84852218
            5460-5540           JAXUCZ010000008.1  84854500-84854580
            5541-11272          JAXUCZ010000008.1  84854833-84860564
FEATURES             Location/Qualifiers
     source          1..11272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..11272
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="myosin VA"
                     /db_xref="GeneID:25017"
                     /db_xref="RGD:3143"
     exon            1..86
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..5693
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dilute-opisthotonus; myosin-Va; dilute myosin heavy chain,
                     non-muscle; myosin 5a; unconventional myosin-Va"
                     /codon_start=1
                     /product="unconventional myosin-Va isoform 1"
                     /protein_id="NP_001423326.1"
                     /db_xref="GeneID:25017"
                     /db_xref="RGD:3143"
                     /translation="MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEE
                     GKDLEYRLDPKTSELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTY
                     CGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSII
                     VSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSS
                     RFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM
                     LRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILH
                     LGNVGFASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPIS
                     KLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFETFEINSFE
                     QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDL
                     LDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLE
                     KNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRP
                     GQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLR
                     ACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLGDRKQTCQNVLEKLILDKDK
                     YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQR
                     YVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLARNR
                     YRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIEARS
                     VERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERLQ
                     LSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYKQETEQLVSNLKEE
                     NTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLLNEFSRL
                     EERYDDLKEEMTLMLNVPKPGHKRTDSTHSSNESEYTFSSEFAETEDIAPRTEEPTEK
                     KVPLDMSLFLKLQKRVTELEQEKQLMQDELDRKEEQVLRSKAKEEERPQIRGAELEYE
                     SLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTAVSEELDVR
                     KEEVLILRSQLVSQKEAIQPKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSA
                     MDYQELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQ
                     QQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYRISLYKRMID
                     LMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRKEKD
                     FQGMLEYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVR
                     SLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEH
                     CLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGL
                     RKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNL
                     LLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDD
                     DAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQVRLRDRKDSPQLLMD
                     AKHIFPVTFPFNPSSLALETIQIPASLGLGFIARV"
     misc_feature    78..4394
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    78..4394
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    306..2312
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="class V myosin, motor domain; Region: MYSc_Myo5;
                     cd01380"
                     /db_xref="CDD:276831"
     misc_feature    306..2312
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="class V myosin, motor domain; Region: MYSc_Myo5;
                     cd01380"
                     /db_xref="CDD:276831"
     misc_feature    order(390..416,546..569,684..716,1368..1385)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(390..416,546..569,684..716,1368..1385)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276831"
     misc_feature    390..416
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    390..416
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    546..569
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="P-loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    546..569
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="P-loop; other site"
                     /db_xref="CDD:276831"
     misc_feature    684..716
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch I region; other site"
                     /db_xref="CDD:276831"
     misc_feature    684..716
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch I region; other site"
                     /db_xref="CDD:276831"
     misc_feature    1368..1394
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch II region; other site"
                     /db_xref="CDD:276831"
     misc_feature    1368..1394
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="switch II region; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(1455..1490,1497..1526)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     misc_feature    order(1455..1490,1497..1526)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     misc_feature    2112..2144
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276831"
     misc_feature    2112..2144
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(2175..2207,2265..2312)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276831"
     misc_feature    order(2175..2207,2265..2312)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276831"
     misc_feature    4566..5690
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Cargo binding domain of myosin 5a; Region:
                     Myo5a_CBD; cd15478"
                     /db_xref="CDD:271262"
     misc_feature    4566..5690
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="Cargo binding domain of myosin 5a; Region:
                     Myo5a_CBD; cd15478"
                     /db_xref="CDD:271262"
     misc_feature    order(4617..4625,4632..4643,5151..5156,5628..5630,
                     5643..5645,5649..5651,5655..5663)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="RILPL2 interface [polypeptide binding]; other site"
                     /db_xref="CDD:271262"
     misc_feature    order(4617..4625,4632..4643,5151..5156,5628..5630,
                     5643..5645,5649..5651,5655..5663)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="RILPL2 interface [polypeptide binding]; other site"
                     /db_xref="CDD:271262"
     misc_feature    order(4701..4703,4710..4715,4722..4727,4734..4739,
                     4746..4748,4839..4841,4893..4910,4914..4919,4926..4928)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="melanophilin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271262"
     misc_feature    order(4701..4703,4710..4715,4722..4727,4734..4739,
                     4746..4748,4839..4841,4893..4910,4914..4919,4926..4928)
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /note="melanophilin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271262"
     exon            87..197
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            198..369
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            370..514
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            515..671
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            672..815
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            816..897
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1005
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1112
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1378
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1460
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1601
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1727
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1811
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1973
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2071
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2158
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2267
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2479
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2636
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2876
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3125
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3219
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3368
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3482
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3626
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3680
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3908
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4009
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4090
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4289
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4364
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4458
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4605
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4760
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..4850
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..5001
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5284
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5285..5459
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5460..5540
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
     exon            5541..11272
                     /gene="Myo5a"
                     /gene_synonym="Dop; Myh12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccac gcgagctgcg gcctccgccc aggcgggggg cgtcggcgct gggcccgcca
       61 tggccgcgtc cgagctctac accaagtttg cccgggtttg gatacctgat cctgaggaag
      121 tgtggaaatc agctgagttg ctcaaggact ataaacctgg agataaggtg ctcctgcttc
      181 accttgagga agggaaggat ttggaatacc gtctagatcc aaagaccagc gagctccctc
      241 acctacggaa ccctgacata cttgttggag aaaatgacct cacagccctc agctaccttc
      301 acgagcctgc tgtgctgcac aatctccgcg tccgcttcat cgactccaaa ctcatttata
      361 cgtattgtgg gatagtcctg gtagctataa atccctatga gcagctgcct atctatggag
      421 aagatatcat taatgcatac agtggccaga acatgggtga catggaccct cacatctttg
      481 cagtagctga agaggcctat aaacaaatgg caagggacga acgaaatcag tccatcattg
      541 taagtggaga gtcaggtgca gggaagacag tctcggctaa gtatgccatg aggtacttcg
      601 caactgtaag tggctctgcc agtgaggcca atgttgagga aaaggtcttg gcctccaacc
      661 ccatcatgga gtcaattgga aatgctaaaa caaccaggaa tgataatagc agccggtttg
      721 ggaaatatat tgaaattggt tttgacaaga gatatcgaat catcggtgcc aatatgagaa
      781 cttacctttt agagaaatcc agagtggtgt tccaggcaga agaggagaga aactaccata
      841 tcttctatca gctctgtgct tcggcaaagc tacctgagtt taagatgctg cggttaggaa
      901 atgcagatag tttccattac acgaagcaag gaggcagccc tatgatagaa ggagtggacg
      961 atgcgaagga gatggcacac accaggcagg cctgcactct gctgggaatt agtgaatctt
     1021 accaaatggg aatttttcgg atacttgctg gcattcttca cttaggcaat gttgggtttg
     1081 cgtctcgaga ttcagacagc tgcacaatac ctcccaagca cgagcctctt atcattttct
     1141 gtgatcttat gggtgtggat tatgaagaga tgtgtcactg gctctgccac cgaaagctag
     1201 ctaccgccac agagacgtac atcaagccca tctccaagct gcaggccaca aatgcccgag
     1261 acgctttagc aaagcatatc tatgcaaagc tctttaactg gattgtcggc catgtcaatc
     1321 aggctctcca ttcagctgtc aagcagcact ctttcatcgg cgtgctggac atttatggat
     1381 ttgaaacatt tgagataaat agttttgaac agttctgcat aaattatgca aatgaaaagc
     1441 tacagcaaca attcaacatg catgtcttca aactggaaca ggaggagtac atgaaggaac
     1501 aaattccatg gacactcata gatttctatg ataatcagcc ttgtatcaat cttatagaat
     1561 ctaaactggg tattctagat ttgctggatg aggaatgtaa gatgcctaaa ggtaccgatg
     1621 acacatgggc ccaaaaacta tacaacacac atttgaacaa atgtgctctc tttgagaagc
     1681 cccgcatgtc aaacaaagct ttcatcatca aacattttgc tgacaaagtg gagtaccagt
     1741 gtgaaggttt tcttgaaaag aataaagaca ctgtttttga agaacaaatt aaagtcctta
     1801 agtcaagcaa gtttaagatg ctaccagaac tatttcaaga tgacgagaag gccatcagtc
     1861 ccacctctgc cacttcctca ggacgcacac ctctcacacg ggtacctgta aagcccacca
     1921 agggtcgacc tggccagact gccaaagagc acaagaagac agtgggactt cagtttcgaa
     1981 actcccttca cctgcttatg gaaaccctta acgccactac tcctcactat gttcgctgta
     2041 ttaagcccaa tgatttcaag tttccattca catttgatga gaagagagca gtacagcagc
     2101 taagagcatg tggtgtcctg gagaccatcc ggatcagcgc agcagggttt ccctcaaggt
     2161 ggacttatca agagtttttc agccggtacc gggtcctaat gaagcaaaag gatgtgctgg
     2221 gagatagaaa gcaaacatgc cagaatgtat tagagaaact gatactggac aaggataaat
     2281 accagtttgg taagacaaag atcttttttc gtgctggtca agtggcctat ctagaaaaat
     2341 tgagggctga caaactgagg gcggcctgca tccggatcca gaagacgatt cgtgggtggc
     2401 tgctgaggaa gagatacctg tgtatgcaga gggcagccat cacagtgcag cgatacgtgc
     2461 gtggctatca ggctcgatgc tatgctaagt ttctgcgcag aaccaaggca gcaaccacca
     2521 ttcagaagta ctggcgcatg tatgtggtcc gcaggaagta caagattaga cgagctgcca
     2581 ccattgttct tcagtcttat ttgagaggct acttggcaag aaataggtat cgcaagatac
     2641 tccgtgagca caaagcagtc atcattcaga aacgtgtccg tggctggctg gctcgtacac
     2701 attataagag gaccatgaaa gccatcatct accttcaatg ctgcttccgg cggatgatgg
     2761 ccaagcgtga gctgaagaaa ctcaaaattg aggctcgctc tgtggaacgc tacaagaagc
     2821 tccatattgg catggaaaac aagattatgc agctgcaacg caaagtggat gagcagaata
     2881 aagactacaa atgcctcatg gagaaactga ccaatctaga aggagtatac aactctgaga
     2941 ctgaaaaact acgaaatgat gtagaacgtc ttcagctaag cgaggaggaa gctaaggttg
     3001 ccactgggag agtgcttagt ctgcaggaag aaattgcaaa actccgaaaa gacctggaac
     3061 aaactcgatc ggagaaaaag tccattgaag aacgagcaga taaatacaaa caagaaactg
     3121 agcagctggt gtcaaacttg aaggaagaaa acactctgct gaagcaggaa aaggagaccc
     3181 tcaatcacct catggtggag caggctaagg agatgacaga aactatggag aggaagttag
     3241 tagaagaaac aaaacaactg gagctcgacc tgaatgatga gaggctgagg tatcagaacc
     3301 tcctgaatga gttcagtcgt ctggaggagc gctatgacga cctcaaggaa gagatgaccc
     3361 tgatgctgaa tgtgcctaag ccaggacaca agagaacaga ctctacccac agcagcaatg
     3421 agtctgaata caccttcagc tcagaatttg cagaaactga agacattgca ccaaggacag
     3481 aggagccaac tgagaagaag gtgcctctgg atatgtcatt gttccttaag ctccagaagc
     3541 gtgtcacaga gctggaacag gagaagcagt tgatgcagga tgagctggac cgaaaggagg
     3601 agcaggtgtt gcgcagcaag gcaaaggaag aagaaagacc acagattaga ggtgctgaac
     3661 tggaatatga gtccctcaag cgtcaggaac tggagtcaga aaacaaaaag ctgaagaatg
     3721 agctgaatga gctacgcaaa gccctgagtg agaagagtgc ccccgaagtg actgcgccag
     3781 gcgcgcccgc ttaccgcgtc ctcatggagc agctgacggc cgtgagcgag gagctcgatg
     3841 tccgcaagga ggaagtcctc atcttaaggt ctcagctggt gagccagaaa gaagccatcc
     3901 aacccaagaa tacaatgaca gattccacaa tacttttgga agatgtacag aaaatgaaag
     3961 acaaaggtga aatagcacaa gcatatattg gtttgaaaga aacgaacaga tcatctgcta
     4021 tggattacca ggagttgaat gaggatggag aactctggct ggtttatgaa gggttaaaac
     4081 aagccaacag gctcttagaa tcccagctac agtcgcagaa gaggagccat gaaaatgagg
     4141 ctgaggccct ccgtggggag atccagagcc taaaggaaga aaacaaccgg caacagcagc
     4201 tgctggccca gaacctgcag ctgccccctg aggcccgcat tgaggccagc ctgcagcatg
     4261 agatcacccg gctgaccaat gaaaacctgt attttgagga attatatgca gatgacccta
     4321 agaagtatca atcctatcgg atttcacttt acaaaaggat gattgatctg atggaacaac
     4381 ttgaaaagca ggataaaacc gtccggaaac tgaagaaaca actaaaagtc tttgccaaaa
     4441 aaatcggtga actagaagtg gggcagatgg agaacatatc cccaggacag atcatcgatg
     4501 agcctatccg gccggtcaac attccccgga aagaaaagga tttccaaggg atgctggagt
     4561 acaagcggga ggacgaacag aagcttgtta agaacctgat tctagaacta aagccacgtg
     4621 gtgtggctgt caatctgatt ccagggttac cggcatatat cttgtttatg tgtgtgcgac
     4681 atgccgacta cctgaacgat gatcagaaag taagatcatt gctgacatca acaattaaca
     4741 gcatcaaaaa agtcctgaag aaaagaggtg acgattttga aactgtctcc ttctggctct
     4801 ctaacacatg tcgatttttg cactgtttga agcaatatag tggagaagag ggcttcatga
     4861 aacacaacac gtctcgccag aatgaacact gcctcaccaa ttttgacctt gctgagtatc
     4921 ggcaagtact gagtgacttg gccattcaga tctatcagca gcttgtgagg gtgttagaga
     4981 acattcttca gccaatgata gtctcaggca tgctagagca tgaaacaatt cagggagtat
     5041 ctggggtgaa gcccacagga ctcagaaagc gaacctccag tatcgccgat gagggcacct
     5101 acacactgga ctccatcctg cggcagctca actccttcca ttccgtcatg tgtcagcatg
     5161 gcatggaccc agagctaatc aagcaggtgg tcaagcagat gttctacatc gtgggcgcca
     5221 tcaccctgaa caacctcctg ctgcgcaagg acatgtgctc ctggagcaaa ggcatgcaga
     5281 tacggtacaa tgtcagtcaa ttggaagaat ggctacgtga caagaatcta atgaacagtg
     5341 gggcaaaaga gactctggaa cctcttatcc aggctgctca gcttttgcaa gtgaaaaaga
     5401 aaactgacga tgacgcggaa gccatctgct ccatgtgcaa cgctctgacc acagcccaga
     5461 tcgtcaaagt gttgaatctg tacacacccg ttaatgagtt tgaggaaagg gtctctgttt
     5521 catttatccg cactatacag gtgcggttac gagacaggaa agactctcca cagctgctca
     5581 tggatgcaaa acacatcttt cctgtcactt tcccctttaa cccatcctcc ctggccctag
     5641 aaaccatcca gattccagcc agcctgggcc tgggcttcat tgcaagggtc tgaagggcta
     5701 cccaagcaaa tgtagagaac gcatttctcc tcaaaacatg aacagttgtt tccagtgagc
     5761 tactgaaaat acatttttaa agaaaaaaaa atactgatta tctctagaag aagatgctaa
     5821 ctggaattcc cccccagaat cctttcaatt gtgaagacgc tccttgtact gttaccttta
     5881 aagcaacatt cattctctat cagttgggaa ccctgagttt acatacagct gaatggtggc
     5941 agggaagagt gaaagaaaag atgaaagggg cttgtcttca gctgacagca tttagtttaa
     6001 gtctttagtg ctgcatttaa gtacaatccc atatgtctga actgttgtga acaaggcaca
     6061 aagaactgaa gaaaatcact gaatacatat catagcagtt taggagccaa tcatggtaat
     6121 attgtcaaac tggatcaaaa aaaataaact ggcaacatta aagtaactgg ccaagtaact
     6181 tccttatctg tcagtacggc atagccatgt gaaagacatt gttgctaggc agcgtagatg
     6241 ccggtttgta ctgtagctta ctgagcatct taaatggctg ctgtgtgctg tctcctgacg
     6301 taagtgatag tcttattagg cactacaaaa taagcttctc tttcatcagc tctgtttaca
     6361 attcaaccag accagttcta actggattat atgcaattat ccacaggttc atcggctcga
     6421 gtagcagaca ctggggaagt agagttaggc agagtggctg ttgatgtcat tgctgatcag
     6481 gaggtattac attgataagt cacccgtgcg gatcgcacat catgcttagt gctgtgtgaa
     6541 gttgcttgtt ttcagttccg aaatctgatt cttgccaggc atagattcaa ccttgacaag
     6601 ttttcttctt aatttattaa gtgttagttt cagtcactat ctagaaagga ctatcagaat
     6661 atttatgatt aagatcttga aactgattat cctataagtt attcaaaata ggcatataaa
     6721 taaatcatta taattcagag ggtttaggtg ttgcaacctc tataaatgtt ctcagatacc
     6781 actggatact ttaaaaacat catattataa atacattaag aagatttatg taagaaatat
     6841 aagattatta aattttatag aggatttggt tcagtaagac ccagattctg tatgttttca
     6901 ttatgaaatt ctaattaagc ataatctcca tttttttctg gaactcttat ataataaatc
     6961 ctttgggttt tgcaagagca aattcttagc tttcgttcct ttggctgcta attgcaatca
     7021 tcgatttgta tggtttactg taaggtggtt ggtctgaaac agtggcattt aaatatgtgc
     7081 aatattattc ctgagagcta aacggtttca agtcagtgat aaatactgtt agtaaacgga
     7141 agttattgtt cattatctta ctggagttta taaactttcc ttgtttataa agtaagaggg
     7201 ttggacaact ggttgttcca gccacttccc tgtttacagt tcacgcatgc ggggtttcta
     7261 gagaaagggg tcacagttac tctgtcctgt tgtaaagacc aatgtttagt gcctgtcagt
     7321 tccctagggt tagtacacta agtcacgagt ttatgtaacc acaatctttt cttaacatac
     7381 atcatttagg tcttttagaa caccctaatt atttgtatta tttgaaagtt acttagttta
     7441 agtaactttt gttacaggat aaactttttg tttgtttgtt tgtttgtttg tttgtttgtt
     7501 tgtttaggga attttgtttt ctgcagtgct gggaattaca cccaaggcct cttgtgtgtt
     7561 aaatcagtac tctaccactg agtgagtctc aactcctatt cagttccagt gcattgattt
     7621 atttgcagaa cctacaacac tactcaacgt cttcagtttt cctgggttct cagtattgtt
     7681 gcagtgaaca gttaagccat ctcactagta ctgagtcaga cagcatagag gtagtgggtg
     7741 gaagaacttg ctaagcaaac agagccttgt gtaggctgtc ttccctcact cagccctggc
     7801 aggacgccca caccctgctc ccagcttagt cctgagtggg aagctgatgc acaccccgag
     7861 tcttgtcttc aggaccaggc tgtcatgctc tgtccctgaa accccatttc cctacttcag
     7921 acatttgtgc cctacagttt ctagcacttt ctctcatttt tctctgttgt caaagctggg
     7981 gctcctgttc tacagctgct cccattttgt ggttctcggg tttcagtgac aatggttcag
     8041 agtcgctgtg attccaagct tcaactcttt caagctatcg gaacccagat agtgattgtc
     8101 tgcactgctt tgttaaggag agaggcacca ggcttgtgct cacccccact ctgtcatcca
     8161 tactctccta gcttcaaaca cacacccagc cttcccccta cctgtcccat ccggcacctc
     8221 cctaatctta ccagcctgat gggtttctgt ggccctggct ggcatgcgtg ggactcatca
     8281 tcactcccgt cctcactttt gtactcctta accttaccac taattggctt tcccataatt
     8341 ccactatgat atgcttggac tacaaagaag gagctcttga aagacacaac agcacagcag
     8401 ttcttccttg cagtagcccc tcccagcagc caccactgac ctgctgtagc ttcactcact
     8461 ccacagtaag gatccacagt gaggaaagac gccttttctc ttcccttcct gcctcttttc
     8521 ttagccccag gcttgaatct gccttcgagt aactcaaaat gaggaaaaga tcaacacaaa
     8581 tcaatccgca caaaggacaa cttgtggttc ctttggaact ttgaacattc catactacct
     8641 ggcactactt tggaaagcaa atgtacagac agaactgtaa tccagagcca agtgataggg
     8701 gatgtcagtc tgtgccagtt tagattgcct gatttgttac tgattcactt cagtagctaa
     8761 agagagactc cttatgggtg agcaggtgta ggtcatgcgc atattcctta atggtgtata
     8821 cagaaggcta tgaagatact tcaggcctca gtgtcccaat tattgtgaga aattagtttt
     8881 ctgacagttg taggaagagg agctgccgcc atcctgagaa ctccacatgc agtgcctctc
     8941 ccacacacac acacagtcac cagttgagag ctcctcagga agcatggtca agggtcctcc
     9001 gggtagcatc agcctgttag gatgaagagc aaatgtccgt gtgtgacact gtggtcctgt
     9061 tggaagtagt gcagagacag tacccatagt gcatgtgctt cacgccagca actctccctc
     9121 cgttacctca cttcctcaca gcatccacag gagacagctc ccaccatcaa tggggatgat
     9181 aatttgggac aatggtatgg tcagtggctc gctggaagtg gcactgcctt ttagcagtaa
     9241 gggcagaggc tgtcctgtct ctccatatgc tgtggggtaa cctggctagt aagggtgctc
     9301 tgtgtcgtta ttggcatgtg ggaagagatg aatgatgagc accagcttac ttgttgggag
     9361 accagtgcgc agtgcccgca gcactagctg tgactaggct tgccttttgt ggtgaaccag
     9421 tactccttga cagggtgcgg actcttgagt tagaggctgt ctgaagtaga agggcgggta
     9481 gcagtgaaaa cctcagatgt gaagaggcaa ggcaggccac tctccacaac catgaggttt
     9541 ccctgtgaga gccccaggct gaactacaca gcctacagag aactctctag ttttagtctg
     9601 aggcacagag gaacccagga cactaagtac ctccctccct ggggctgtct gccaatggcg
     9661 agtcagtgta aacttggaat tgccacagca cacagcccgc aggggaggtg ctaggagctg
     9721 tgctgtgggc atgcatgctt gaggccacaa gcattttgtg gaaagtgctt tgtagtttgt
     9781 tctcaggctg tgctgtgagg gccgccttaa cccttgcccc ttcccttcta gagctgcctt
     9841 aagttcccca gaacttgtcc tcagtgaggg ttatcttgcc gtgtttctca aggttttgta
     9901 aggatttgaa ttgggtgtgg cttcccacca ccacgtattc ctttctcccc tttctgcata
     9961 tcctgctacc tatgtgcaac catttccaac cagaggttag aatttataaa gcaaccaatg
    10021 aaatgttagc tttaggaata tttctgggtt agtgcaagtc cctgaacagt aagcaaatta
    10081 gcatgcatgg aacccggcca gaagttggtg tatttgtggg tggcttgcct ttcactaacc
    10141 ctttctaata aaggcaaaaa tacaactcta aaaactttgt gtggtgccct actgtacaag
    10201 gctgagtaaa aacaagaaag tagctgtatt aagttctaat ccaccatagc atagtaccta
    10261 aattaacttt agagtttagt caatttctca ataggtcaaa aagcaaaaga tgccatgtca
    10321 aacatctccc aaatgcattt tatacatttt tattttataa tttggtctcc taaaaatgtt
    10381 tgttagctta acttagtggg tagaactaca ctcataacat atctaaaagc aacaaacatt
    10441 tcctcggcag tgctattgtt tgcaatagtt ggggaagttt tgggtttgtt tttaaaggtt
    10501 gaaatttccg tgtacaattt aatgcttgca aagttaataa ccccaatgcg ttttccagag
    10561 tcagtagttt caaataactt attgtctcta tgtataataa aatcttagct ctctaagtca
    10621 tgtgagccat tatttttttc ccacaaaagg tgatttctcc tttaagtgta gatctgtgtt
    10681 gtgatttatg atccagaatt gtgttctttt gtggattctg aagtaaatga ttttcttgtg
    10741 tttgggaaag tctcaattgt tccagcagta ttgtacagat gagctcatgg cgtttaaccc
    10801 attgtggttt tatttcaact gttcatcact taccatgaaa tggacctgcc tttggaatac
    10861 agtaaatggt tgcagttttc taatcttttt cttccttgga tctggagaaa gaatttcctt
    10921 gatctgcaca gttgatctct gcaaagtggt tagtcgggga agcagaaatg catgctgaca
    10981 ggtgagaggc gttaccaagc ctcgctggat ctaaactgaa cccactccag agtatcgcac
    11041 aggaaatctt ctcgaatgtc aagaattcac ctcatatcaa caaaagcctt ggaaacacga
    11101 gtttttcact gggtattacc taatgctaaa aggaaagcca aaacaatatc agaatgacat
    11161 tttatgctct aaatttatag ctgtctactg tgcttagtgt gtctgtcatt agtgctgtat
    11221 tctcctagct attatagaaa attgttgaaa taaagataag gatataaaga aa
//
LOCUS       NM_001436403            5135 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), transcript variant 1, mRNA.
ACCESSION   NM_001436403 XM_006243218
VERSION     NM_001436403.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5135)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5135)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 5135)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 5135)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_006243218.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.33954.1,
                                           SRR26643298.44707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              JAXUCZ010000008.1  70753436-70754534
            1100-1200           JAXUCZ010000008.1  70755028-70755128
            1201-1264           JAXUCZ010000008.1  70755588-70755651
            1265-1309           JAXUCZ010000008.1  70756612-70756656
            1310-1372           JAXUCZ010000008.1  70774229-70774291
            1373-1447           JAXUCZ010000008.1  70775659-70775733
            1448-1652           JAXUCZ010000008.1  70782797-70783001
            1653-1669           JAXUCZ010000008.1  70784419-70784435
            1670-1789           JAXUCZ010000008.1  70788295-70788414
            1790-1840           JAXUCZ010000008.1  70789262-70789312
            1841-1993           JAXUCZ010000008.1  70789717-70789869
            1994-2126           JAXUCZ010000008.1  70790230-70790362
            2127-2326           JAXUCZ010000008.1  70790810-70791009
            2327-2403           JAXUCZ010000008.1  70792121-70792197
            2404-2653           JAXUCZ010000008.1  70793078-70793327
            2654-2901           JAXUCZ010000008.1  70793690-70793937
            2902-3049           JAXUCZ010000008.1  70794731-70794878
            3050-3200           JAXUCZ010000008.1  70795421-70795571
            3201-3277           JAXUCZ010000008.1  70796240-70796316
            3278-5135           JAXUCZ010000008.1  70797223-70799080
FEATURES             Location/Qualifiers
     source          1..5135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5135
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..1099
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    680..682
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="upstream in-frame stop codon"
     CDS             1076..3385
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducin-like enhancer protein 3; rTLE3; transducin-like
                     enhancer of split 3, E(spl) homolog; transducin-like
                     enhancer of split 3, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 3 homolog of Drosophila;
                     transducin-like enhancer of split 3 (E(sp1) homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform 1"
                     /protein_id="NP_001423332.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNI
                     PSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVS
                     ADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKI
                     WDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIK
                     AELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS
                     HDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV
                     LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSS
                     VLSCDISADDKYIVTGSGDKKATVYEVIY"
     misc_feature    1076..1468
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Q domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1127..1474
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Groucho/TLE N-terminal Q-rich domain; Region:
                     TLE_N; pfam03920"
                     /db_xref="CDD:461094"
     misc_feature    1463..1564
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1469..1672
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: GP domain. /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1625..2122
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1673..1879
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
     misc_feature    1682..1684
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1694..1696
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1706..1708
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1724..1726
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1748..1759
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    1769..1771
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1793..1795
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1808..1810
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    <1826..2482
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1826..2482
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1850..1852
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1862..1864
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1874..1876
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    1898..1900
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); acetylation site"
     misc_feature    1931..1933
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2009..2011
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2024..2026
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2030..2032
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2036..2038
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2057..2059
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2075..2077
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2303..2305
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q9JIT3.1); phosphorylation site"
     misc_feature    2516..2632
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 1"
     misc_feature    <2519..3376
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <2519..3376
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    2531..2650
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2531..2650
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2654..2773
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 2"
     misc_feature    2672..2788
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2672..2788
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2786..2905
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 3"
     misc_feature    2801..2911
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2801..2911
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2912..3031
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 4"
     misc_feature    2930..3037
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2930..3037
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3035..3154
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 5"
     misc_feature    3050..3151
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3050..3151
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3158..3277
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 6"
     misc_feature    3173..3277
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3173..3277
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3281..3379
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIT3.1);
                     Region: WD 7"
     misc_feature    3296..3370
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    3296..3370
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1100..1200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1264
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1309
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1372
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1447
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1652
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1669
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1789
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1840
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1993
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2126
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2326
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2403
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2653
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2901
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3049
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3200
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3277
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..5135
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcggcc cccttcgcct
       61 gtctgtgtgt ggtatccgca ggtccgagcc actttttttt tttttttgag tgcgtgtacg
      121 tgtgtgtgtt gagtgcgtgt gtttgtgtgt tttgggggtt tggcggggcg cggagaggag
      181 agccaggctg ggaggaagga aagaagccgc agagctcccg ggctcaggct acgtctcccc
      241 ctccggtgct ctccagcctg cgcgctccta ggcagcaggg acgccgaccg ctccccgccg
      301 gagacgcagc cgattcactt gagagcaaag aagacccctt cgccgaggct tcctatgccg
      361 gctggagtta ggatgccacg gcccattatt tgcaccgact aacccggagt tcctcctcgg
      421 ccctgggaag gactggcggc ggcggctgga gcagacagag cagcaggctc tcttctccga
      481 ggggaggggg gggcgtcgaa gcgccctcgc tgggctctag ccctcaccca cggtcctcaa
      541 gccgtcacct cggtggcctg cttccttttt cttctccccg cgactccggg cccgaccgcc
      601 tctgggattt gacccgcgcg ccccggatgc tccgagctgc ccagacgcgc ccccccccct
      661 ccagcctcat cgtgctgatt gacccgtgag gggacaagag aaacccaccc cccaacctcc
      721 gggcctcggg atcctgctct ggagctgcca gggagccgat gatgtccacg cagacccggc
      781 ttctgacact gtccacgcag ccgggggaag gtggccggcc gcagccggcc gagccttagg
      841 cgcacaaagc gcgagcccgc cgacgacttt gccgctcgct ccgccgctct ttgtctgcac
      901 ttggggcgca cgcccgactc tgggatttcg ctgcgagagc gggctggggg ggccgggggc
      961 gagctctcgg ttccccggcc gccccccgct cgggctcgcc tcccccctcc cccgcacgtc
     1021 cccggctcgg gctctcagcg cttccaagct ctcggaatcg cgacccctcc ctgccatgta
     1081 tccgcaaggc agacatccgg caccccatca acccgggcag ccaggattta aattcactgt
     1141 ggccgagtcc tgtgacagga tcaaagacga attccagttc ctgcaagctc agtatcacag
     1201 cctcaaagtg gagtacgaca agctggcgaa cgagaagaca gagatgcagc gccattatgt
     1261 gatgtactat gagatgtcct acggcttgaa tatcgaaatg cacaagcaga cagagatcgc
     1321 gaagagactg aacacgattc tagcccagat catgcctttt ttgtcacagg agcatcagca
     1381 gcaagtggcg caggctgtgg aacgcgccaa gcaggtcacc atgacggagc tgaacgccat
     1441 catcgggcag cagcaactcc aggcacagca cctctcccat gccacacatg gtcccccggt
     1501 ccagctgcca ccccacccgt caggcctcca acctcctggg attcccccag tgacaggaag
     1561 cagctctggg ttgctggcac ttggtgccct gggaagccaa gcccacttgg cagtgaagga
     1621 tgagaagaac catcatgaac tggatcacag agagagagag tccagcacga acaattctgt
     1681 gtcaccctca gaaagcctcc gggccagtga gaagcaccgg ggctctgcag actacagcat
     1741 ggaagccaag aagcggaaag cggaagagaa agacagcctg agccgatacg acagcgatgg
     1801 ggacaagagt gatgacctgg tagtggatgt ctccaatgag gacccagcga caccccgggt
     1861 gagcccagca cactcccctc ctgaaaatgg gctggacaaa gcccgaggtc tgaagaaaga
     1921 cgcccccacc agcccagcct ctgtggcttc ctccagcagc acgccttcct ccaagaccaa
     1981 agaccttggt cataatgaca aatcttccac acctgggctc aagtccaaca caccaacgcc
     2041 aaggaacgat gccccaactc caggcaccag caccaccccg gggctccggt caatgccggg
     2101 caaacctcca ggcatggacc cgatagcctc ggccctgcgc acacccatct ccctcaccag
     2161 ctcctatgca gcaccctttg ccatgatgag ccaccacgag atgaatggct ccctcaccag
     2221 cccaagcgcc tatgctggcc tacacaacat cccatcccag atgagcgccg ccgcagcagc
     2281 tgcagccgcc gcctatggcc gatcgccaat ggtgagcttt ggagctgttg gttttgaccc
     2341 tcatcccccg atgcgggcca caggcctgcc ctccagtctt gcctccattc ctggagggaa
     2401 accggcgtac tccttccatg tgagtgccga cgggcagatg caacctgtgc ccttccccca
     2461 tgatgcgcta gcaggccccg gcattcccag gcatgcccgg cagatcaaca cactcagcca
     2521 tggggaggtg gtatgtgccg tgaccatcag caaccccacg aggcacgtct acacaggcgg
     2581 caagggctgt gtgaagatat gggacatcag ccagccgggc agcaagagtc ccatctccca
     2641 gctggactgc ctgaacaggg acaactacat ccgctcatgc aagcttctcc ctgatgggcg
     2701 cacgctcatt gtgggtggtg aggccagcac actcaccatc tgggacctgg cctcgcccac
     2761 gccccgcatc aaggctgagc tgacgtcctc ggctccagcc tgttacgccc tggccatcag
     2821 tcctgatgcc aaagtctgtt tctcctgctg cagtgatggg aacattgcag tttgggatct
     2881 gcacaaccag accctggtca ggcagttcca gggccacacg gatggggcca gctgtataga
     2941 catctctcat gatggcacta aactgtggac cgggggcctg gacaacactg tgcgctcctg
     3001 ggacctgcgt gaagggcggc agctacagca acacgacttc acctcccaga tcttctccct
     3061 gggttactgc cccactgggg agtggctcgc cgtgggcatg gagagcagca acgtagaggt
     3121 tctgcaccac accaagccgg acaagtacca actgcatctg cacgagagct gcgtgctgtc
     3181 cctcaagttt gcctactgtg gcaagtggtt tgtgagcact gggaaagaca accttctcaa
     3241 tgcctggagg acgccttacg gagccagcat cttccagtct aaagaatcct cgtccgtctt
     3301 gagctgtgat atttcagcgg atgacaaata tattgtaacg ggctctggtg acaagaaggc
     3361 cacagtttac gaggtcatct actgaacaag gactctaaga ggcctgtcaa actctgggag
     3421 acacccacgc ggccctgaca gggagatgct ggccaggccc cgaggatggc agaagagtga
     3481 gggacagcat tgtggggctg ccctccggaa ggtggagagg acgcacgccc ctttgtggat
     3541 tgctgtgtct gacagacttg aaggactttc tcctctcccc ctcaccagtg ctggcagatg
     3601 cttcaattag atttctctgg aggcttctgc tttcgtttcc cacacagaca ccctcatgag
     3661 tctctgtctc ttcctcccct gtctgatctg tcccctccct actccgggtt gggggcatgc
     3721 tggagtagac attgttgttt ctggggaggg gcgcctcgtt ctgattgtgc agtgcacaag
     3781 gtttgtgaac aatgtaaata agagactgtg gttgctgact ggccagtgag ggaggaggcc
     3841 ccttcccacc agtgctcgcc gtgtattttg cctgctgtat ttgtaaccca ctcgcggtgg
     3901 tggcttttct ttctttcttt tcttaagatt ttttttaaac agatgttctg tggggaaagt
     3961 aggcagagat agagagtcgg ggagtggaat gagaagcttc ctggggatgg gcaaaccagc
     4021 ctggcccact gggactgaag tatatctcca cacgggtttt agcaccatct tcagatggaa
     4081 tgataggcag atggacagac aagctgatgg acagacagta ctgggatggg ccagcttggg
     4141 ctattatcca caggaacagc gaggatttcc tgtgggtttc tctgctccat cttctcttgc
     4201 cttgccctca cacctcctga cctccatctc tttctgcccc cctccccccg ctcgcctctc
     4261 ccactggacc ccatctttct ctttggtgca cactcaatca ttgtgatgag gaatggaagt
     4321 tcaagggaac tccctctctg actctcctcc gccagcctag aaaggattcc atatgggggt
     4381 gggagggaga caagcgactc agctcaggga gctaccagag aaaaacagca actggtgtgg
     4441 gtgctttttt ttttaatttg aataaaaata attagaagtg atatcctttg ataagatgcc
     4501 gtctcccctt tcctgctctc agccctttct gctccctgaa gccggggata tggtgacccc
     4561 cagggtcgta agtctaagaa gatgggcggg ggagcgggct gggggctggg gcagacggaa
     4621 tgtcatctgc agatatcacc cctagggtac caatgtttgt ggtattaggt ttgctttgtt
     4681 ttgttttggt cttttgttgt tttattaaag aaaagctaaa gaccgtgtga gccctgctgg
     4741 tgggctttcc atggatgtag catatggaag agagttttta tattgcattt ttatggatta
     4801 ttttataatg tgggactcag tctgggaaga aagatgaggg tgtctaaaac ctgcccatct
     4861 ccagtgctcc aactgagcgg ctgccccgaa caggatgtat gttgggacat ggaaagaccg
     4921 tggcaccccg caccttcctg agaggcatgt cgacatgcct gtctggagtc tgtccatctg
     4981 tctctgggtt tcagatgatc actggccacc acttgttaag gctctagcca gaagggaggg
     5041 ttagggtgga agagagttat tcctgaagaa aaaagaaaaa ttgaaacatc attgtaatga
     5101 agctttttat atttttaaaa gttactattt aaaaa
//
LOCUS       NM_001436392           10041 bp    mRNA    linear   ROD 13-MAR-2025
DEFINITION  Rattus norvegicus nitric oxide synthase 1 (Nos1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436392 XM_063271043
VERSION     NM_001436392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10041)
  AUTHORS   Jiang,T., Wan,G., Zhang,H., Gyawali,Y.P., Underbakke,E.S. and
            Feng,C.
  TITLE     Mapping the Intersubunit Interdomain FMN-Heme Interactions in
            Neuronal Nitric Oxide Synthase by Targeted Quantitative
            Cross-Linking Mass Spectrometry
  JOURNAL   Biochemistry 63 (11), 1395-1411 (2024)
   PUBMED   38747545
  REMARK    GeneRIF: Mapping the Intersubunit Interdomain FMN-Heme Interactions
            in Neuronal Nitric Oxide Synthase by Targeted Quantitative
            Cross-Linking Mass Spectrometry.
REFERENCE   2  (bases 1 to 10041)
  AUTHORS   Gyawali,Y.P., Jiang,T., Yang,J., Zheng,H., Liu,R., Zhang,H. and
            Feng,C.
  TITLE     Differential superoxide production in phosphorylated neuronal
            nitric oxide synthase mu and alpha variants
  JOURNAL   J Inorg Biochem 251, 112454 (2024)
   PUBMED   38100901
  REMARK    GeneRIF: Differential superoxide production in phosphorylated
            neuronal nitric oxide synthase mu and alpha variants.
REFERENCE   3  (bases 1 to 10041)
  AUTHORS   Chen,R., Qian,L., Fu,J., Qin,J., Chen,X. and Xu,X.
  TITLE     Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways
  JOURNAL   Neurochem Int 169, 105586 (2023)
   PUBMED   37442439
  REMARK    GeneRIF: Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways.
REFERENCE   4  (bases 1 to 10041)
  AUTHORS   Yang,Z., Li,P., Yuan,Q., Wang,X., Ma,H.H. and Zhuan,B.
  TITLE     Inhibition of miR-4640-5p alleviates pulmonary hypertension in
            chronic obstructive pulmonary disease patients by regulating nitric
            oxide synthase 1
  JOURNAL   Respir Res 24 (1), 92 (2023)
   PUBMED   36964568
  REMARK    GeneRIF: Inhibition of miR-4640-5p alleviates pulmonary
            hypertension in chronic obstructive pulmonary disease patients by
            regulating nitric oxide synthase 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10041)
  AUTHORS   Vasu,D., Li,H., Hardy,C.D., Poulos,T.L. and Silverman,R.B.
  TITLE     2-Aminopyridines with a shortened amino sidechain as potent,
            selective, and highly permeable human neuronal nitric oxide
            synthase inhibitors
  JOURNAL   Bioorg Med Chem 69, 116878 (2022)
   PUBMED   35772285
REFERENCE   6  (bases 1 to 10041)
  AUTHORS   Kobzik,L., Reid,M.B., Bredt,D.S. and Stamler,J.S.
  TITLE     Nitric oxide in skeletal muscle
  JOURNAL   Nature 372 (6506), 546-548 (1994)
   PUBMED   7527495
REFERENCE   7  (bases 1 to 10041)
  AUTHORS   Seo,H.G., Tatsumi,H., Fujii,J., Nishikawa,A., Suzuki,K., Kangawa,K.
            and Taniguchi,N.
  TITLE     Nitric oxide synthase from rat colorectum: purification, peptide
            sequencing, partial PCR cloning, and immunohistochemistry
  JOURNAL   J Biochem 115 (3), 602-607 (1994)
   PUBMED   7520037
REFERENCE   8  (bases 1 to 10041)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   9  (bases 1 to 10041)
  AUTHORS   Bredt,D.S., Hwang,P.M., Glatt,C.E., Lowenstein,C., Reed,R.R. and
            Snyder,S.H.
  TITLE     Cloned and expressed nitric oxide synthase structurally resembles
            cytochrome P-450 reductase
  JOURNAL   Nature 351 (6329), 714-718 (1991)
   PUBMED   1712077
REFERENCE   10 (bases 1 to 10041)
  AUTHORS   Bredt,D.S. and Snyder,S.H.
  TITLE     Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 682-685 (1990)
   PUBMED   1689048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 11, 2025 this sequence version replaced XM_063271043.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360194.858313.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000012.1  44395492-44395612   c
            122-1208            JAXUCZ010000012.1  44371027-44372113   c
            1209-1335           JAXUCZ010000012.1  44361500-44361626   c
            1336-1464           JAXUCZ010000012.1  44346837-44346965   c
            1465-1610           JAXUCZ010000012.1  44344899-44345044   c
            1611-1773           JAXUCZ010000012.1  44343943-44344105   c
            1774-1865           JAXUCZ010000012.1  44342991-44343082   c
            1866-2007           JAXUCZ010000012.1  44340688-44340829   c
            2008-2147           JAXUCZ010000012.1  44337541-44337680   c
            2148-2322           JAXUCZ010000012.1  44335088-44335262   c
            2323-2424           JAXUCZ010000012.1  44332341-44332442   c
            2425-2619           JAXUCZ010000012.1  44330155-44330349   c
            2620-2705           JAXUCZ010000012.1  44329533-44329618   c
            2706-2850           JAXUCZ010000012.1  44327523-44327667   c
            2851-2955           JAXUCZ010000012.1  44326477-44326581   c
            2956-3014           JAXUCZ010000012.1  44325945-44326003   c
            3015-3131           JAXUCZ010000012.1  44320884-44321000   c
            3132-3306           JAXUCZ010000012.1  44317855-44318029   c
            3307-3445           JAXUCZ010000012.1  44315332-44315470   c
            3446-3524           JAXUCZ010000012.1  44314553-44314631   c
            3525-3718           JAXUCZ010000012.1  44304537-44304730   c
            3719-3888           JAXUCZ010000012.1  44302662-44302831   c
            3889-4099           JAXUCZ010000012.1  44298305-44298515   c
            4100-4187           JAXUCZ010000012.1  44297546-44297633   c
            4188-4309           JAXUCZ010000012.1  44295692-44295813   c
            4310-4458           JAXUCZ010000012.1  44294100-44294248   c
            4459-4653           JAXUCZ010000012.1  44291819-44292013   c
            4654-4772           JAXUCZ010000012.1  44288836-44288954   c
            4773-10041          JAXUCZ010000012.1  44282462-44287730   c
FEATURES             Location/Qualifiers
     source          1..10041
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..10041
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="nitric oxide synthase 1"
                     /db_xref="GeneID:24598"
                     /db_xref="RGD:3184"
     exon            1..121
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1208
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    469..471
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="upstream in-frame stop codon"
     CDS             499..4788
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /EC_number="1.14.13.39"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nitric oxide synthase, brain; nitric oxidase synthase;
                     nNOS; N-NOS; NC-NOS; NOS type I; neuronal NOS;
                     constitutive NOS; peptidyl-cysteine S-nitrosylase NOS1;
                     nitric oxide synthase 1, neuronal"
                     /codon_start=1
                     /product="nitric oxide synthase 1 isoform 2"
                     /protein_id="NP_001423321.1"
                     /db_xref="GeneID:24598"
                     /db_xref="RGD:3184"
                     /translation="MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIIS
                     DLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEG
                     FTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQ
                     HAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKAT
                     NRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSE
                     KEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGS
                     IMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTS
                     TYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYAT
                     NKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQ
                     GWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPA
                     VSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSL
                     WKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPP
                     MSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKF
                     SAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEH
                     EALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRK
                     SSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKM
                     REGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLT
                     YVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPG
                     DHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPC
                     TIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTM
                     VEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEG
                     PVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ
                     RQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPK
                     KYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAG
                     VFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS"
     misc_feature    499..1098
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Interaction with NOSIP.
                     /evidence=ECO:0000269|PubMed:15548660"
     misc_feature    538..867
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="PDZ domain of neuronal nitric oxide synthase
                     (nNOS), and related domains; Region: PDZ_nNOS-like;
                     cd06708"
                     /db_xref="CDD:467192"
     misc_feature    538..867
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="PDZ domain of neuronal nitric oxide synthase
                     (nNOS), and related domains; Region: PDZ_nNOS-like;
                     cd06708"
                     /db_xref="CDD:467192"
     misc_feature    order(577..597,628..630,637..639,727..729,739..741,
                     748..753)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467192"
     misc_feature    order(577..597,628..630,637..639,727..729,739..741,
                     748..753)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467192"
     misc_feature    952..1020
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    985..1218
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Interaction with DYNLL1/PIN.
                     /evidence=ECO:0000269|PubMed:8864115"
     misc_feature    1138..1263
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1309..1392
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1336..1338
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0J4; propagated from
                     UniProtKB/Swiss-Prot (P29476.1); phosphorylation site"
     misc_feature    1396..2631
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Nitric oxide synthase (NOS) eukaryotic oxygenase
                     domain. NOS produces nitric oxide (NO) by catalyzing a
                     five-electron heme-based oxidation of a guanidine nitrogen
                     of L-arginine to L-citrulline via two successive
                     monooxygenation reactions producing N...; Region:
                     NOS_oxygenase_euk; cd00795"
                     /db_xref="CDD:238410"
     misc_feature    1396..2631
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Nitric oxide synthase (NOS) eukaryotic oxygenase
                     domain. NOS produces nitric oxide (NO) by catalyzing a
                     five-electron heme-based oxidation of a guanidine nitrogen
                     of L-arginine to L-citrulline via two successive
                     monooxygenation reactions producing N...; Region:
                     NOS_oxygenase_euk; cd00795"
                     /db_xref="CDD:238410"
     misc_feature    order(1414..1419,1450..1452,1456..1458,1468..1470,
                     1474..1494,1498..1500,1504..1506,2296..2298,2302..2304,
                     2362..2364,2377..2382,2392..2394,2410..2412,2449..2454,
                     2542..2544,2548..2556,2572..2574,2578..2592)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238410"
     misc_feature    order(1414..1419,1450..1452,1456..1458,1468..1470,
                     1474..1494,1498..1500,1504..1506,2296..2298,2302..2304,
                     2362..2364,2377..2382,2392..2394,2410..2412,2449..2454,
                     2542..2544,2548..2556,2572..2574,2578..2592)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238410"
     misc_feature    order(1741..1743,1930..1932,2182..2184,2248..2253,
                     2257..2262,2272..2274,2284..2289,2527..2532,2614..2616)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="active site"
                     /db_xref="CDD:238410"
     misc_feature    order(1741..1743,1930..1932,2182..2184,2248..2253,
                     2257..2262,2272..2274,2284..2289,2527..2532,2614..2616)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="active site"
                     /db_xref="CDD:238410"
     misc_feature    2671..2733
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="propagated from UniProtKB/Swiss-Prot (P29476.1);
                     Region: Calmodulin-binding.
                     /evidence=ECO:0000269|PubMed:1712077"
     misc_feature    2767..3288
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    2767..3288
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    3037..3039
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P29476.1); phosphorylation site"
     misc_feature    3067..3069
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0J4; propagated from
                     UniProtKB/Swiss-Prot (P29476.1); phosphorylation site"
     misc_feature    3070..3072
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P29476.1); phosphorylation site"
     misc_feature    3484..4695
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="The ferredoxin-reductase (FNR) like C-terminal
                     domain of the nitric oxide synthase (NOS) fuses with a
                     heme-containing N-terminal oxidase domain. The reductase
                     portion is similar in structure to NADPH dependent
                     cytochrome-450 reductase (CYPOR), having an; Region:
                     Nitric_oxide_synthase; cd06202"
                     /db_xref="CDD:99799"
     misc_feature    3484..4695
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="The ferredoxin-reductase (FNR) like C-terminal
                     domain of the nitric oxide synthase (NOS) fuses with a
                     heme-containing N-terminal oxidase domain. The reductase
                     portion is similar in structure to NADPH dependent
                     cytochrome-450 reductase (CYPOR), having an...; Region:
                     Nitric_oxide_synthase; cd06202"
                     /db_xref="CDD:99799"
     misc_feature    order(3565..3567,3733..3738,4042..4044,4051..4053,
                     4186..4188,4210..4212)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99799"
     misc_feature    order(3565..3567,3733..3738,4042..4044,4051..4053,
                     4186..4188,4210..4212)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99799"
     misc_feature    order(3592..3594,4015..4026,4069..4071,4075..4077,
                     4123..4134)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(3592..3594,4015..4026,4069..4071,4075..4077,
                     4123..4134)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4015..4017,4021..4026)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4015..4017,4021..4026)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4024..4026,4543..4545,4675..4677,4681..4683)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99799"
     misc_feature    order(4024..4026,4543..4545,4675..4677,4681..4683)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99799"
     misc_feature    order(4075..4086,4243..4245,4249..4251,4345..4350,
                     4435..4440,4462..4464,4468..4470,4558..4560)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4075..4086,4243..4245,4249..4251,4345..4350,
                     4435..4440,4462..4464,4468..4470,4558..4560)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4123..4125,4132..4134,4141..4143)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4123..4125,4132..4134,4141..4143)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4234..4236,4246..4257,4261..4263)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99799"
     misc_feature    order(4234..4236,4246..4257,4261..4263)
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99799"
     exon            1209..1335
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1464
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1610
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1773
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1865
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2007
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2147
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2322
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2424
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2619
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2705
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2850
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2955
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3014
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3131
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3306
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3445
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3524
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3718
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3888
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4099
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4187
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4309
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4458
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4653
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4654..4772
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..10041
                     /gene="Nos1"
                     /gene_synonym="bNOS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatcctgcc ccggagcgag gctctggatc cgcgcgctca gcagctgcgg gaggaggagg
       61 cgcggaagac agggtgatca gcgggatcca cagccctgga actgcgcggg ctcggcagca
      121 gctccaggta gaagccccta tgtcacctct gcgtctgaca agctggtgac caagatgccc
      181 agagactaga ccctatgctt gtgagtcaca gtcatcagac acggcaaacc tccagtcttc
      241 ctgacctgtt gcttagggat acatcccgtt gctgcccctg acgtctgcct ggtcaacctt
      301 gacttccttt gagagtaagg aagggggcgg ggacacgttg aaatcatgcc acccaaggcc
      361 gaatggcaat gagcagatga cgccaagttg acgtcaaaga cagaggcgac agaaactctg
      421 cagccagctc ttgcccccga ggagctcagg ttcctgcagg agtcatttta gcttagtctt
      481 ctgaaggaca cagataccat ggaagagaac acgtttgggg ttcagcagat ccaacccaat
      541 gtaatttctg ttcgtctctt caaacgcaaa gtgggaggtc tgggcttcct ggtgaaggaa
      601 cgggtcagca agcctcccgt gatcatctca gacctgattc gaggaggtgc tgcggagcag
      661 agcggcctta tccaagctgg agacatcatt ctcgcagtca acgatcggcc cttggtagac
      721 ctcagctatg acagtgccct ggaggttctc aggggcattg cctctgagac ccacgtggtc
      781 ctcattctga ggggccctga gggcttcact acacatctgg agaccacctt cacaggggat
      841 ggaaccccca agaccatccg ggtgacccag cccctcggtc ctcccaccaa agccgtcgat
      901 ctgtctcacc agccttcagc cagcaaagac cagtcattag cagtagacag agtcacaggt
      961 ctgggtaatg gccctcagca tgcccaaggc catgggcagg gagctggctc agtctcccaa
     1021 gctaatggtg tggccattga ccccacgatg aaaagcacca aggccaacct ccaggacatc
     1081 ggggaacatg atgaactgct caaagagata gaacctgtgc tgagcatcct caacagtggg
     1141 agcaaagcca ccaacagagg gggaccagcc aaagcagaga tgaaagacac aggaatccag
     1201 gtggacagag acctcgatgg caaatcgcac aaagctccgc ccctgggcgg ggacaatgac
     1261 cgcgtcttca atgacctgtg ggggaaggac aacgttcctg tggtccttaa caacccgtat
     1321 tcagagaagg aacagtcccc tacctcgggg aaacagtctc ccaccaagaa cggcagccct
     1381 tccaggtgcc cccgtttcct caaggtcaag aactgggaga cggacgtggt cctcaccgac
     1441 accctgcacc tgaagagcac actggaaacg gggtgcacag agcacatctg catgggctcg
     1501 atcatgctgc cttcccagca cacgcggaag ccagaagatg tccgcacaaa ggaccagctc
     1561 ttccctctag ccaaagaatt tctcgaccaa tactactcat ccattaagag atttggctcc
     1621 aaggcccaca tggacaggct ggaggaggtg aacaaggaga ttgaaagcac cagcacctac
     1681 cagctcaagg acaccgagct catctatggc gccaagcatg cctggcggaa cgcctctcga
     1741 tgtgtgggca ggatccagtg gtccaagctg caggtgttcg atgcccgaga ctgcaccaca
     1801 gcccacggca tgttcaacta catctgtaac catgtcaagt atgccaccaa caaagggaat
     1861 ctcaggtcgg ccatcacgat attccctcag aggactgacg gcaaacatga cttccgagtg
     1921 tggaactcgc agctcatccg ctacgcgggc tacaagcagc cagatggctc taccttgggg
     1981 gatccagcca atgtgcagtt cacggagatc tgtatacagc agggctggaa agccccaaga
     2041 ggccgcttcg acgtgctgcc tctcctgctt caggccaatg gcaatgaccc tgagctcttc
     2101 cagatccccc cagagctggt gctggaagtg cccatcaggc accccaagtt cgactggttt
     2161 aaggacctgg ggctcaaatg gtatggcctc cccgctgtgt ccaacatgct gctggagatc
     2221 gggggcctgg agttcagcgc ctgtcccttc agcggctggt acatgggcac agagatcggc
     2281 gtccgtgact actgtgacaa ctctcgatac aacatcctgg aggaagtagc caagaagatg
     2341 gatttggaca tgaggaagac ctcgtccctc tggaaggacc aagcactggt ggagatcaac
     2401 attgctgttc tatatagctt ccagagtgac aaggtgacca tcgttgacca ccactctgcc
     2461 acggagtcct tcatcaaaca catggagaat gaataccgct gcagaggggg ctgccccgcc
     2521 gactgggtgt ggattgtgcc tcccatgtcg ggcagcatca cccctgtctt ccaccaggag
     2581 atgctcaact atagactcac cccgtccttt gaataccagc ctgatccatg gaacacccac
     2641 gtgtggaagg gcaccaacgg gacccccacg aagcggcgag ctatcggctt taagaaattg
     2701 gcagaggccg tcaagttctc agccaagcta atggggcagg ccatggccaa gagggtcaag
     2761 gcgaccattc tctacgccac agagacaggc aaatcacaag cctatgccaa gaccctgtgt
     2821 gagatcttca agcacgcctt cgatgccaag gcaatgtcca tggaggagta tgacatcgtg
     2881 cacctggagc acgaagccct ggtcttggtg gtcaccagca cctttggcaa tggagacccc
     2941 cctgagaacg gggagaaatt cggctgtgct ttaatggaga tgaggcaccc caactctgtg
     3001 caggaggaga gaaagagcta caaggtccga ttcaacagcg tctcctccta ttctgactcc
     3061 cgaaagtcat cgggcgacgg acccgacctc agagacaact ttgaaagtac tggacccctg
     3121 gccaatgtga ggttctcagt gttcggcctc ggctctcggg cgtaccccca cttctgtgcc
     3181 tttgggcatg cggtggacac cctcctggag gaactgggag gggagaggat tctgaagatg
     3241 agggaggggg atgagctttg cggacaggaa gaagctttca ggacctgggc caagaaagtc
     3301 ttcaaggcag cctgtgatgt gttctgcgtg ggggatgacg tcaacatcga gaaggcgaac
     3361 aactccctca ttagcaatga ccgaagctgg aagaggaaca agttccgcct cacgtatgtg
     3421 gcggaagctc cagatctgac ccaaggtctt tccaatgttc acaaaaaacg agtctcggct
     3481 gctcgactcc tcagccgcca aaacctgcaa agccctaagt ccagccgatc gaccatcttc
     3541 gtgcgtctcc acaccaacgg gaatcaggag ctgcagtacc agccagggga ccacctgggt
     3601 gtcttccccg gcaaccacga ggacctcgtg aatgcactca ttgaacggct ggaggatgca
     3661 ccgcctgcca accacgtggt gaaggtggag atgctggagg agaggaacac tgctctgggt
     3721 gtcatcagta attggaagga tgaatctcgc ctcccaccct gcaccatctt ccaggccttc
     3781 aagtactacc tggacatcac cacgccgccc acgcccctgc agctgcagca gttcgcctct
     3841 ctggccacta atgagaaaga gaagcagcgg ttgctggtcc tcagcaaggg gctccaggaa
     3901 tatgaggagt ggaagtgggg caagaacccc acaatggtgg aggtgctgga ggagttcccg
     3961 tccatccaga tgccggctac acttctcctc actcagctgt cgctgctgca gcctcgctac
     4021 tactccatca gctcctctcc agacatgtac cccgacgagg tgcacctcac cgtggccatc
     4081 gtctcctacc acacccgaga cggagaagga ccggtccacc acggggtgtg ctcctcctgg
     4141 ctcaacagaa tacaggctga cgatgtagtc ccctgcttcg tgagaggtgc ccctagcttc
     4201 cacctgcctc gaaaccccca ggtgccttgc atcctggttg gcccaggcac tggcatcgca
     4261 cccttccgaa gcttctggca acagcgacaa tttgacatcc aacacaaagg aatgaatccg
     4321 tgccccatgg ttctggtctt tgggtgtcga caatccaaga tagatcatat ctacagagag
     4381 gagaccctgc aggccaagaa caagggcgtc ttcagagagc tgtacactgc ctattcccgg
     4441 gaaccggaca ggccaaagaa atatgtacag gacgtgctgc aggaacagct ggctgagtct
     4501 gtgtaccgcg ccctgaagga gcaaggaggc cacatttatg tctgtgggga cgttaccatg
     4561 gccgccgatg tcctcaaagc catccagcgc ataatgaccc agcaggggaa actctcagag
     4621 gaggacgctg gtgtattcat cagcaggctg agggatgaca accggtacca cgaggacatc
     4681 tttggagtca ccctcagaac gtatgaagtg accaaccgcc ttagatctga gtccatcgcc
     4741 ttcatcgaag agagcaaaaa agacgcagat gaggttttca gctcctaact ggatcctcct
     4801 gcccccgtgc gtgcgatgtg gggcggctgc cccaagtgcc caagtgaggg cggccgcagg
     4861 ttgactaaat tcggacacac acggctgaac cgagtggccc tgctctgcct cttgtcctgt
     4921 tgctgtgtcc tggtccttct tcctgctctg ggctctctca accccacccc tgggttttct
     4981 ccttgactct tgggctacga tgcatcaccc ttgtaccctg cagtggctct cacaaaaccg
     5041 catcctcccc acccccaccc gattgctgcc aagggcaggt tgcggtgcat ggctgttgct
     5101 cctgttgctg gggtctgaag gtggctggcg ctgggcctca ggtcaccctg aaccagtccc
     5161 ttggccactt aagccccctt ccaccctctt tttatgatgg tgtgtttgtg tgtgtgtgtg
     5221 tgtgtgtgtg tgagagagag agagagagag agagagagag gagtgtccta gatcattctc
     5281 tgtccttttg cctgcacatg cgtgctgacc tgacctgtgg ttccactgcc ttctcagagg
     5341 atgttcagtg ccacgaaacg tgttcctaga tactgttaat ccctcccacg tccaccatga
     5401 caggcctgtg tcagcctccc ggaagcacat caggccccct tactaagcac agaagagaca
     5461 ggcgcacgtg gagagggagg tgtccctatg gaggagccaa ccacagaatc caaggtgttc
     5521 agagtctgac cctctcggca gaggtctgtc tgggaaatcc accagacagt ggattggcca
     5581 agctcctctc cattctcacc aaccccagct ggggccaaca ggatgttgag ctgtctttcc
     5641 caggcaaccc tagctctggg cccagcagcc atactgtacc aggaagcatg ctgggagtaa
     5701 ggtctttgcc accaagggta cttgggttac ccttccaagt tcatcttcat taatcgagtg
     5761 gataggcctt tctcagtgct ttggagcctt gacggatgtc agggaggaat agggtatctg
     5821 cttttcatgc ctcctgctag acagtggttc ccttccccca aaacaagcag cataggcaac
     5881 agaattctag ccgtggcccg ttggctctcg gaggtaagca tcttctgagg ctgtgcagtg
     5941 gttccttatt actataagta aaagttacat cagatggtac tgacagtcaa gaaaccccca
     6001 gagtccccag gctcaagaga ttagctctgg ggtcccatgt tctgtgtccc cgtttggttg
     6061 tgtgaggcag aaagaaaaaa cccaaacaaa ccgtgctggg gcctgctttc ctaatgttaa
     6121 aaatgaaggc tgtcaaatag aaaattcttt acagttgtgg ggcccgaaac cctaagggct
     6181 ccaaccccac cccctttttt ctctgtcttc tttcttttcc ttccttccct ttcctttctt
     6241 tttcccccag agtctcctgt ttctcaggct gactttgaac tcatgacctc taattcctaa
     6301 ccctaccaca tccagtttgt gatcttgcca gaggctcaaa gccggaacct cctgcgtgct
     6361 aggccagcac tctaccagcc aagctacatc cccagccttc agtccccacc cccaagatca
     6421 gagacaggtc tcccgtggca ctggacaacc ctgccaggtc ccatcactag catgggaact
     6481 tggtcctagt taaaatctca cacctgccct accttagtac cactgtttcc tacttggtct
     6541 tccatctctg tggagactta gccctcagta cccccagagc caccttctgt accccaaagg
     6601 taaggcagta acttcctact gacctcaaac acagaccccc aaacacagtc ccagggacgt
     6661 tctcctcaac ctttcaagcc tctggggacg cttaaaacgt agtttattcc cctgatctga
     6721 accgctaggc ccaacctccg ttgaagagcc ctctctctct gcaagccaag atgcatgcac
     6781 acacctctga ataaggaacg ctactctgtg acaggctcca cccccacccc cacccccacc
     6841 cccggatatc cccgtgctgc cagtagcgag tggacagatg gaagccccgt gtcatttgcc
     6901 agagtccaaa gacaccagtt acataaccag gttcaagagg gacttctgtt catcagtgct
     6961 agggatggga cccaggacct cacacattcc tggctgaact attcccccaa ccccaccccc
     7021 acccgcaaag agaatatttt taaaagacat ctgaactctt gacacaggca gcttccttgg
     7081 ctcctggcta ggaggctggg ggtcagtcgg gtacttcgct cctttttcaa aatgccttaa
     7141 gcagcttatc caaaggctaa gcaaaggtgg gcgtctgggg tgggtcaata ctgccctctg
     7201 ctggtggttt ttagttcaag cccagcaaca agcccaaaag tacggcttag actaggagaa
     7261 ccgagtgggt aaacttgttt gtttacattg tcgcagtagc tccaactgtt tcacaagagt
     7321 aggtttgccc atttacactc tctgctgttc ctgtggctgt ggtccccaag gagctcagcc
     7381 cacgggaggt ggcagggctt ccctgcacgt cctcgaagaa agcagtgcct ttctttggga
     7441 ggcggggggg gggggggggg gggctggtat ttaggtccca ctatgatgca agcagacctg
     7501 acccacattc tattgctgcc ccgtttatgc agaaggtgat tccggattgt acctgagcaa
     7561 gagaatgtcc cgggacagta ccaacccaag ctctgataag cctccacctt ccctttcctt
     7621 tacacctgcc gcttcccagc agcaagataa ctagcctgag ggaggggaga ggcaggcaga
     7681 gtcatggatt cttaggctaa atcagcaaga cctggtaccc gtccgtggta gagtgaagac
     7741 agacagagta gagagatccc ggcctctggg tgaagaagga agttgaatcg ggcctcagta
     7801 caaagggaga aagctaagtt ggcccaaaaa acacaggacc aagggtgccg gtttccctga
     7861 tgaagccccc tgcttcagga tgcaagggtg aagattttgt tctagcccta ggcaaaatgg
     7921 aaagtttctg accctgatgt ctgaacaccc cccatccctg cagggtgtct ctgtctgtct
     7981 gtttctctct ctctctctct ctctctctct ctctctctct ctctctctct gtgggtttgt
     8041 gtgtctgtct gtctgtcttc tctttctctc tccctcaccc ccctctgtca cctgtcactc
     8101 tgtcttctct ctctccttct ccctcctctc tctctgtctc tgtctctctt tccccccacc
     8161 cccctctctc tctctcatgc acacacctac acagccacac agagcctgtt cactggaagc
     8221 tgtgggcttc caggttaagt tcagccaagg gacccaatgc agacagcctt cagggacagg
     8281 gtccagcctt gagagttcca ggaggccagg ctagcgcact cacacgctcg ctctctcttg
     8341 tgctctctct tgcgctctct ctctctctct ctgtctctgt ctctctctct ccctctctct
     8401 ctctctctct ctctctctct ctctctctct ctctctctct cgtcaggcac cacctagagg
     8461 gaaaggcacc caagaggaga agttgaccat gctatgtctc aagcatggag acccagggac
     8521 cccagagaat ctgttttcta ttacaagtct gacatcttaa tccccagtgc caaaatgctc
     8581 cagaatctaa agcgttttga gtgccaacag gctaccacaa ctaaaaactt cagttcctct
     8641 acaaaagtat ttaaaagaat acgtagactg gacgtgaagc tcaaggatag agctcaccta
     8701 gcatgccaag tcctggaccc catcccagca tggcaaacaa attgcctcag gctgtctgtg
     8761 tgaaacatga atgcatctca tgtttagagg cagctcccac ctgccaaaca tctcgtcaag
     8821 aatatgcaaa tattacaaaa tcaaaaataa ttcccaaatc cgaaacactt cttgtcaaat
     8881 gagcttcaaa gtacagtcaa cctatcagag acaagggtga tgccgggggt gagagtgcct
     8941 cagccgtgtt tatgaatttg tttggttcag acatatctgc gtggttctgg ataactgggc
     9001 atctctgacc caagtcagtc agtccttttc taatgaggtg tccctggaag gtagaagtgg
     9061 ggttgacttt aggaactgat cacctctgtc tcctagacaa gtcagaacgg gaactgacct
     9121 ctaggagatt gtagtcagga gcccgctaac cttggccgcc atgttgttca gagctgaaga
     9181 agtctttgta ttacagggta ttgcaggacg ctgattgaac agtatctgta cccttcccct
     9241 actagatgtc actagcaacc tcctgccatg tgtgacagcc acaatggtca ccagaaagta
     9301 gtgttccctg ggaaggcagg cgggaccttc aaccattgga ccaagaaatc cttgcttttg
     9361 ggtctcaggg gctatagaac tgtctgcctg atgctgtggg ccgtccgctt acagatctgg
     9421 aggaggtcag cagaacctgc ctcggttcaa tggttgctta cctgctccca accgagatcc
     9481 gaaagctttg cggagggtcc caatccagag ggtgggctac gtgtttttaa gatagatatt
     9541 ccaaggcacc atctctcgtg ctgggtctaa ggttatcccc atcccccgtc tgtgccctga
     9601 gctccgtctc cccacttgtg ttgtccttgt gactgtacga ccaaccgacc cacttcagac
     9661 tcagcagttg tctgctgaag tcccaagaca ttagggtcag gttacaccca gaggtgttca
     9721 ctgtggggtt acagggaggc tggagagaat gggcagagct tgggttccat cacaacacct
     9781 ataagctgtc agaaacccga tgccccaccc acccacctcc agcatctcta agctgctaat
     9841 ctctgccacg tgtcccgtgt gctccagcac cgccaccaac cgcctgccat gcccgccttc
     9901 cgtgaggttg tccaggctgt gttctcgcat gcttctctct tctatataac cctcttcctc
     9961 tcattctatg ggatccaaca caaagtctac tcatgcttgt ttgcattatg gttaaactat
    10021 taaaaagaaa atgcagactg a
//
LOCUS       NM_001436531            2048 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), transcript variant 3, mRNA.
ACCESSION   NM_001436531 XM_017595743
VERSION     NM_001436531.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_017595743.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.7120.1,
                                           SRR26360176.1387325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840120
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  96988079-96988139
            62-174              JAXUCZ010000008.1  97006495-97006607
            175-308             JAXUCZ010000008.1  97007968-97008101
            309-408             JAXUCZ010000008.1  97016484-97016583
            409-2048            JAXUCZ010000008.1  97022942-97024581
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2048
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..61
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            62..174
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="upstream in-frame stop codon"
     exon            175..308
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..799
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001423460.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     misc_feature    221..478
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     misc_feature    221..478
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     exon            309..408
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            409..2048
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccactgg cggtggcggc acagcagcgg tgaggctcgc gcaccggagg agctggaccg
       61 tgggaacgac ttaattcctg acactggcag gtatctgggc cctggcagtt aactctttgg
      121 acattgtgaa ttggatacgc tgtgaagggc tctctgacca gcattgcaaa ctaggatgga
      181 gatgtctgcc cagaggctga cttctaacag aacatcccca cagtcaccat ctaactctga
      241 ctatacctgg gaatacgagt actatgagat cggaccggtt tccttcgaag gactgaaggc
      301 tcacaaatat tccatcgtga ttggattctg ggttggtctt gcggtctttg tgattttcat
      361 gttttttgtg ctgactttgc tgacaaagac aggcgcccca caccaagaca atgcggagtc
      421 ctcagagaag aggttccgaa tgaacagctt tgtgtcagac tttgggaagc ccctggagtc
      481 agacaaggtg ttttctcgtc agggcaatga ggagtccagg tctctgttcc actgttacat
      541 caatgaagtg gaacacttgg acagggttaa agtttgccac cgaacaacag ccattgacag
      601 cgatgtccat ctccaggaag ccatcagaag cagtgggagg cctgaggagg agctaaccag
      661 gtttatgcag tttgacatcc ccaacttcgt gaacacagac cagaactcct ttggggagga
      721 tgatcttctt atttcggaac cacctgttct tctagaaaat aagccagttt cccagacatc
      781 acgtacagac ctggactgag acacacttgt gggtgccttc ctgaggatgt gttctgtttc
      841 tgtgcagcaa gaaaccacat gctacctaca cttgtgtgtg tgtgtgtgga gagagagaga
      901 gagagagaga gagggaggga gagagagaga gagagagagg gggagggagg aggcggcagc
      961 gggtggggaa gaggatgatg tttaaagttt aagacctagg ctaggactgg gatttagtga
     1021 tagaggggca gaatttgaag atgggaggca ccattttgat ttggggaggg tgattttttt
     1081 ctctttggat taaaaatgcc ttgacagtat taaagcttct ttattgaaac gattagccaa
     1141 cacatgcaat tgagctccct cctgggtgag ggctagttcg ctgcagtcgg gtctagccct
     1201 ttcccaccat cctctgcctg taacaagctg ctttgcctct ctggactgcc atggctttac
     1261 aggtaaggtg gcctgtccgg agtagatgac ctatcccagc tctagaattt tgtgactttc
     1321 aaacttagct ataagataag ctaagaaacg cataagcagt agaaaatacc acacggcatc
     1381 gaggctttca tggcaggttc ttcaggtctc ggtgctctcc cttcactcag tccttcactg
     1441 ggtcacactt tcggtaggga aatctttact aggagaccag gagacatgag acttgcacgc
     1501 actgtggaca gtgtctctgc tgggtgttgc tacagcaatt tatgtgctga acgccccccc
     1561 cccccgcttt aaactgggat agcttcgact ccagcgacta ccagcccaaa ctgttttcac
     1621 aagcatctgt gctcttgaag aatggtagag cagattgtta tttggctgat gtgagtccct
     1681 tctggatgtc cctgtgtttg catccctggg ctcacccttc tgaactattt ggcttcagaa
     1741 caggaagata ccgctcgcca tgtctgcgtg gcagatgtgt aggtgacggc tgcctggctt
     1801 ggagctgaga gggtccgtgg gttttttgcc acagtaacag atgttcagga ttggaggatg
     1861 ttaatatgag ccacatgatg tccgtctcac aaagcaagca gccccctttg ctggagtcag
     1921 aaacaaccca gtcctgcaca cacagagttg tacgcatgag cagctgctaa tctctgggtg
     1981 gcatcttctt tatgaatttg ttcaccattt gtcttgctta agttgcaaaa taaatgcatt
     2041 tgatcgca
//
LOCUS       NM_001191997            3414 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 6, mRNA.
ACCESSION   NM_001191997 XM_576410
VERSION     NM_001191997.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3414)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 3414)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001191997.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN12840108, SAMN12840111
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000008.1  60280529-60280738   c
            211-227             JAXUCZ010000008.1  60279934-60279950   c
            228-525             JAXUCZ010000008.1  60277553-60277850   c
            526-683             JAXUCZ010000008.1  60271374-60271531   c
            684-719             JAXUCZ010000008.1  60267495-60267530   c
            720-791             JAXUCZ010000008.1  60266449-60266520   c
            792-891             JAXUCZ010000008.1  60265595-60265694   c
            892-3414            JAXUCZ010000008.1  60261325-60263847   c
FEATURES             Location/Qualifiers
     source          1..3414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3414
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..210
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1252
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6"
                     /codon_start=1
                     /product="layilin isoform 6 precursor"
                     /protein_id="NP_001178926.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGDLDPRGGQRFCWEGT
                     RRPCYRVIYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGD
                     FWIGLKRLEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPP
                     GIGGPYMFQWNDDRCNTKKNFICKYSDDKPSTTPSLSPGGEATEPAAPILPEETLEID
                     TKERREAALNLAYILIPSIPLFLLLVVTSAVCWVWICRRKREQTDPPTKEQHTIWPTP
                     HQENSPDLEVYNVIRKQSEADLAEPRPDLKNISFRVCSGEAMPDDTSCDYDNMVINPS
                     ESGLVTLASMEGRFVTNDIYEFSPDRMGRSKESGWVENEIYY"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    230..676
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    230..676
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(560..562,572..574,578..580,626..628,632..643,
                     650..658)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     misc_feature    order(560..562,572..574,578..580,626..628,632..643,
                     650..658)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     exon            211..227
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            228..525
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            526..683
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            684..719
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            720..791
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            792..891
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            892..3414
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcggtga cttggacccc agaggagggc agcggttctg
      241 ctgggaaggg acacggaggc cttgctacag agtcatttat ttccatgaca cctctcaaag
      301 acggaacttt gaggaagcga aagaagcctg catgaaggat ggaggacagc tagccagcat
      361 agaaacggca gatgagcaga ggctgataga gaacttcatt gaaagcctcc aggcatctga
      421 tggtgatttc tggattggcc tcaagaggtt ggaggagaaa cagcacaaca gcacagcctg
      481 ccaggacctt tacgcttgga cagatggaag cctgtcacag ttcaggaact ggtatatgga
      541 tgagccttcc tgtgagagcg aggtctgcgt ggtcatgtac catcagccat cagcacctcc
      601 gggcatcggg ggcccatata tgttccagtg gaatgacgac cggtgcaaca cgaagaagaa
      661 tttcatttgc aaatattctg acgataaacc aagtacaaca ccctctctta gtcctggagg
      721 tgaagcaact gagccagcag cacccatact tccagaagaa actctggaaa tagacaccaa
      781 agaacgcaga gaggctgctt tgaatcttgc ctacatccta attcccagta ttcccctttt
      841 cctcctactt gtggtcactt cagctgtgtg ttgggtttgg atctgtagaa gaaaacggga
      901 acagacagac cctcccacaa aggagcagca caccatttgg cccactcctc accaagagaa
      961 cagccctgac ctagaagttt acaatgtcat cagaaaacaa agtgaagctg atttagccga
     1021 gccccggcca gatctgaaga acatctcctt ccgggtgtgt tctggggaag ccatgcccga
     1081 tgacacgtct tgtgactatg acaacatggt tataaaccct tctgaaagtg ggttagtgac
     1141 tttggcaagt atggagggta gatttgtgac caatgacatc tatgaattct cccccgacag
     1201 aatggggagg agcaaggaga gtggatgggt agaaaatgaa atatattact aagacatatg
     1261 aaaaaaccag caagaatgta aaaagagaag gaaaagcctc caatgtctta caaagacgat
     1321 attcagaagg cttatgagaa ggttcagctc aggtcttagg ggcaagcaca gcatcacaag
     1381 ttccttctgg gtccccaagt tctggctgca ctccctatcc aggaacctcg tccagctcag
     1441 cctggtccaa ggcacctcac ccaaggggct gctgcacagc agaccctcag agaaagccag
     1501 tggcttccaa ctgacgctca agagctggtg ctttccctgg tcaggattaa ggtgtgacca
     1561 gggagcttgg aaagcctacc tctaggctct gttttccttg ctctgtacat ctgtgcaggc
     1621 aatcacaaag acacaaatgg tgggatcctc tcaaagcctc tgtatggaag ccccaggctg
     1681 gcctgcacat caacaattcc caacctgcat cccaccccca cccctgaaaa aaaaagtcaa
     1741 taaaaagcag gaagcagaat gttagtcagt ctgtgtctac agcccttcct ctgcatgtgg
     1801 cctcagggga gttttttttt tttttttcat tctcccaaca tctaaacttg gaaaagtcca
     1861 acttggaaat actttcgaaa gtaaaaatga gctctgtttg cttcagagct tcttcttctc
     1921 tgggctcaga cagtatgtgc tgttctgggg atgggtggca gcagcatagg aaactgactg
     1981 tatacaggac tggtgaaaag agtcgaccta gtaaggaaaa ggagaggcag gcttctcact
     2041 atcagagaag gcagccacgg tcaccagaag ggaggaaact ggaacaggtc ctgttgtgtg
     2101 caaggggaat cgaaacagtg ctgccgtcat tgtggaattt tatgtactga gtatacatat
     2161 atatgtatgt ttatatgtgt atgtatatgt gtgttttcca ttaaataagc cagtactcca
     2221 tgaaactgga tgactcaagg acagaagcag aagaaatatg agttacttaa gtaatgaaaa
     2281 ggaaataatg ggtatctaaa catagataga attaacaggt ttattgttct acaggaacaa
     2341 tgaggacccg gatatcacaa tgacctataa cgtatttatg aataactatg agaaaggagc
     2401 tcaagggcag caaacacaaa gtcatgataa aaatatattt attgccttgg ttgactagta
     2461 cacattgtat atttgtactg ttaagtaata ccattgttaa aacttaaaga gattgggaat
     2521 gagaatgttc atttgggaaa ttttacacca ccaccaagca agactgatta agaatcagca
     2581 gatagggttg gggatttagc tcagtggtag agtgcttgcc tagcaggcgc aaggccctgg
     2641 gtttggtccc cagctccgga aaaaaaaaaa aaagagagag agagagagaa aaaaaaaaga
     2701 atcagcagat cacagacacc aactcgtaat gatccacctt tggtaatgag gattaatttg
     2761 aatattaaat cattgaaagt aaaaccaaca aagagaatgt gactcaatgg gtaaagtggg
     2821 aaaacatggg catatgctga tacaaaataa aagaataaat taaaactttg atgtagatgg
     2881 tatatttaca tgatttcagg taaagatcat tgattgcaaa agtgacccaa caggcaaagc
     2941 cacctcagtc acctgatgaa tgtgaattct gtggacgacg aagtgtactg agattgtaga
     3001 cctcacactg tggtgtggtg agagggacat ggcatcacat ccacgctgtc tcacagtgta
     3061 caagctgatc ataaggaggc cttgcataac aacaatttga tggacaatct acaaactacc
     3121 tggacggcaa acctgaactc tgatggtaaa gacggtggaa gcgagacagg ggcagctgca
     3181 ataggaggac agtaaggtga tggctccaag cgtgaccaga tcctgaaatg gatccctttt
     3241 ctcctgtaaa ggagaagatg ggaacaaatg tggatgacgt ctgaggacta aatgtcaaaa
     3301 acgtgcagtg ctaacttcct aacttttgcg ttgccctgag gacatggcct cttggcactg
     3361 ggaatgtctt cccagaaagc acacagtgaa gtaataaagg acaatggact atca
//
LOCUS       NM_001436534            3207 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus cysteine and serine rich nuclear protein 1
            (Csrnp1), transcript variant 2, mRNA.
ACCESSION   NM_001436534 XM_006244120
VERSION     NM_001436534.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Ye,X., Lin,J., Lin,Z., Xue,A., Li,L., Zhao,Z., Liu,L., Shen,Y. and
            Cong,B.
  TITLE     Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes
            apoptosis through activating Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 359 (2), 441-448 (2017)
   PUBMED   28830684
  REMARK    GeneRIF: Axud1 mediated stress-induced cardiomyocytes apoptosis
            through activating Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006244120.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.48264.1,
                                           SRR26360181.3171095.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               JAXUCZ010000008.1  128593805-128594208 c
            405-640             JAXUCZ010000008.1  128588091-128588326 c
            641-900             JAXUCZ010000008.1  128585270-128585529 c
            901-1215            JAXUCZ010000008.1  128584548-128584862 c
            1216-3207           JAXUCZ010000008.1  128582364-128584355 c
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3207
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="cysteine and serine rich nuclear protein 1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
     exon            1..404
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    355..357
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="upstream in-frame stop codon"
     exon            405..640
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..2190
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="AXIN1 up-regulated 1"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1"
                     /protein_id="NP_001423463.1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
                     /translation="MAGIQKRKFDQLEEDDCSSSSLSSGDLSPSPPSSSASPAWTSEE
                     EGLGDQPPQPDQDSSGIQSLMPPSILKRAPRERPGHVAFDGITVYYFPRCQGFTSVPS
                     HGGCTLGMASRHSTCRLFSLAEFKQEQFRARREKLRRRLKEEKLEMLKWKLSVSGVPE
                     AGADVPLTVDAIDDASVEEDLAVAVAGGRLEEANFLQPYPPRQRRALLRASGVRRIDR
                     EEKRELQALRQSREDCGCHCDGVCDPETCSCILAGIKCQMDHTSFPCGCCSEGCENPH
                     GRVEFNQARVQTHFIHTLTRLQMEQGAESLGDPESPMEDVPVEQTVVSPFPPSKPTMS
                     NDLGDSSCGSDMTDSSTTYSSGGSGSRSEAPNHLAHPSLPGSSFRSGIDEDSLEQILN
                     FSDSDLGIEEEEEEGGSVGNLDNLSCFHLADIFGTGDPGSLASWTHSQFGSSLPSGIL
                     DENANLDASCFLSSGLEGLREGSLPSSSGSPEGEAAQSSSLDLSLSSCDSFELLQSLP
                     DYSLGPHYTSRRVSGSLDSLETFHPSPSFSPPRDASFLDSLIGLSEPVTDVLAPLLES
                     QFEDTAVVPLDPVPV"
     misc_feature    673..1347
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     misc_feature    673..1347
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     exon            641..900
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1215
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..3207
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgaggct tggtgagtca cggacccttg gagggaggaa gggagggggg aggaggattg
       61 tgtcgtatgt tcacctgtca ccgtcacacg cagaggccac taccgtgagt caccgggcgc
      121 agctaccccg gccacccgcg ggcacacgta ggctctctcc cacgcacctc tactccttct
      181 gcacacattt cctctccttc ctcagtttac ccttcccgga ggtcctttcg ccttcacgta
      241 ctgtagaaat gcctacacca cagcaaccgc cacacactag tcactcgggt tgccggtaca
      301 gtcactccta gacgtagccc accccctgac aacagagaat ccctccctgc tctctagctg
      361 cccacccaac acctctggac cgaagtctca ggcttttgcc cagagccgtc tgtcctcagc
      421 tgcttggaac ccctacatcc caccatggct gggatacaga agaggaagtt tgaccagctg
      481 gaagaggacg actgcagctc ctcctccttg tcctctggcg atctctctcc ctctcctccc
      541 agctcttctg cctcccctgc ctggacctct gaggaggagg gactgggtga tcagccaccc
      601 cagcctgatc aggactccag tggcatccag agtttaatgc ccccatccat cctgaagcgg
      661 gctcctcggg agcgtccggg tcacgtggcc ttcgatggca tcactgtcta ctatttcccg
      721 cggtgccagg gattcaccag tgtgcccagc catggtggct gtaccctggg catggcttct
      781 cgtcatagca cctgccgcct cttctcctta gccgagttta aacaggagca gttccgggct
      841 cggcgtgaga agctccgtcg gcgtttaaag gaggagaagc tagagatgct gaaatggaag
      901 ctttcagtgt ccggagttcc ggaggcaggg gcagacgtgc cgctcacagt ggacgccatc
      961 gatgacgctt ctgtagagga ggacttggca gtggccgtgg caggtggccg cctggaggaa
     1021 gcgaatttcc tacagcccta tccacctcgg cagcgacggg ccctacttcg cgcttccggt
     1081 gttcgaagga ttgaccgaga ggagaagcgc gagctgcagg cgctacgcca atcccgggag
     1141 gattgtggtt gtcactgtga tggcgtctgt gaccctgaga cctgcagttg catcctggcc
     1201 ggcattaaat gccagatgga tcacacgtcc ttcccctgtg gctgctgcag cgagggctgt
     1261 gagaaccccc atggtcgagt ggaattcaat caggcgagag ttcagacaca cttcatccac
     1321 acgctcaccc gcctgcagat ggagcagggt gcggagagtt tgggggaccc ggagtccccc
     1381 atggaggacg ttcctgtcga acaaaccgtg gtttccccct ttcctccttc caaacccact
     1441 atgagcaatg acctggggga cagcagctgt ggcagcgaca tgacagactc ttccacgacc
     1501 tactcctctg gcggcagtgg cagccgcagc gaggctccga accatcttgc ccaccccagc
     1561 ctgccaggtt ccagcttccg gtctggcata gatgaagaca gcctggaaca gatcctgaat
     1621 ttcagtgact ctgacctcgg tattgaggaa gaagaggagg agggagggag tgtgggcaac
     1681 ttggataacc tcagctgttt tcatttggct gacatctttg gtaccggtga ccccggcagc
     1741 ctggctagct ggacacacag ccagtttggc tctagccttc catcgggcat cctagatgag
     1801 aatgccaacc tggacgccag ctgcttccta agcagcggac tcgaagggtt gagagaaggt
     1861 agcctcccca gcagttctgg gtcccctgag ggggaagccg cccagagcag ctccttggac
     1921 ctcagtttat cctcctgtga ctcctttgag cttctccaat ctctgccaga ttatagtctg
     1981 gggcctcact atacttcccg aagggtatct ggcagcctgg acagccttga gaccttccac
     2041 ccttcgccca gcttctctcc accgagggat gccagcttcc tggattctct cataggcctg
     2101 tctgagccgg ttacagatgt cctggcgccc cttctggaga gccagtttga ggacactgct
     2161 gtggtgcctt tggaccctgt gcctgtgtaa ggattgagat gactttttcc tgccctgaga
     2221 ccctgttgct gctttttatg tgatcttggt gtcccccaag gtctgtgtat gtaacggtct
     2281 cccgtgggct ggttctgccc ccgtgccatg tgggcaatcc tctattttta cagtaacact
     2341 ctagatttat ttattttttt atgtttttct gtactgaagg gagggtggga agggtatccc
     2401 tctttcaatg cctggcctct atgtccaaac agaggtctcc cacctcctac tgtatgcctg
     2461 gaggaggaag gggcagggtt cacatcccct ctttctgtac tgtaaaatgc tccttggtcc
     2521 aaagacagct gaaaagcagg ccttagggtt tcctgtggac cgtgggagct aggtcttctg
     2581 gactgtgaag atgtaattta tttctgtaat ttatttgggg actgagacag cagtggttgg
     2641 gcctctctgg caggtgggcg gtgttgaggc aaagtcttcg gtgtcccccg ccggtctggg
     2701 cttcggtgtg gcgtgtaggt tcgagctgag cagacggagg ctgtgcttga ccatcggtga
     2761 tcaaaactcc ctctgccccc tgcccagacg ctctaacatg ccctctgtcc atttccctct
     2821 ccccaaggcc atgggttata aaggccctat gtaggatggg gagccagagg ccctaagaca
     2881 tgaagcacac cccagatcac tgtctctagc ctttctgggc actgaatcca tcctgaccca
     2941 ccacacaccc cccggccagt tggcaagaaa gaggtggctc ttgggggctt ttatgccctt
     3001 cattagctga tgttggattt tatatgcatt tttatattgt ctctaagtgt cagaactata
     3061 atttattcat ttctctgtgt gtgtgtgtgc caagaaacgc aggctctggg cctgcctcct
     3121 tgcccaggag gccttgccag cctgtgtgct tgtgagaaca cattgtacct gagctgacag
     3181 gtaccaataa agacactcta tttttaa
//
LOCUS       NM_001192018            3755 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus galactosidase, beta 1-like 2 (Glb1l2), transcript
            variant 2, mRNA.
ACCESSION   NM_001192018 XM_578717
VERSION     NM_001192018.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001192018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1978458.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000008.1  33442384-33442511   c
            129-176             JAXUCZ010000008.1  33432672-33432719   c
            177-374             JAXUCZ010000008.1  33432033-33432230   c
            375-443             JAXUCZ010000008.1  33430296-33430364   c
            444-539             JAXUCZ010000008.1  33429601-33429696   c
            540-648             JAXUCZ010000008.1  33427276-33427384   c
            649-741             JAXUCZ010000008.1  33415421-33415513   c
            742-823             JAXUCZ010000008.1  33412669-33412750   c
            824-894             JAXUCZ010000008.1  33402492-33402562   c
            895-979             JAXUCZ010000008.1  33400046-33400130   c
            980-1117            JAXUCZ010000008.1  33398755-33398892   c
            1118-1198           JAXUCZ010000008.1  33398103-33398183   c
            1199-1305           JAXUCZ010000008.1  33397502-33397608   c
            1306-1446           JAXUCZ010000008.1  33396800-33396940   c
            1447-1518           JAXUCZ010000008.1  33396496-33396567   c
            1519-1597           JAXUCZ010000008.1  33396178-33396256   c
            1598-1685           JAXUCZ010000008.1  33395117-33395204   c
            1686-1797           JAXUCZ010000008.1  33394725-33394836   c
            1798-1914           JAXUCZ010000008.1  33394238-33394354   c
            1915-3755           JAXUCZ010000008.1  33392106-33393946   c
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3755
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="galactosidase, beta 1-like 2"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
     exon            1..128
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2001
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /EC_number="3.2.1.23"
                     /note="isoform 2 is encoded by transcript variant 2;
                     beta-galactosidase-1-like protein 2"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein 2 isoform 2"
                     /protein_id="NP_001178947.1"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
                     /translation="MPKWSLRRRPGRTLGLLLLLVLSFLVLRRYLNPKVGSCDREGAL
                     RLNWTSVLPLWLQRQRLGLRTKGPNFMLEDSTFQILGGSIHYFRVPREYWRDRLLKLK
                     ACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIWLAAKIGLWVILRPGPYICSEID
                     LGGLPSWLLQDPDMKLRTTYPGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEY
                     GSYNGDHAYMPYIKKALEDRGIIEMLLTSDNKDGLEKGVVDGVLATINLQSQQELVAL
                     NSILLSIQGIQPKMVMEYWTGWFDSWGGSHNILDSSEVLQTVSAIIKDGSSINLYMFH
                     GGTNFGFINGAMHFGDYKADVTSYDYDAILTEAGDYTAKYTKLRELFGTFSGVPPPPP
                     PELTAKMVYEPVTPSFYLSLWDALLYMDKPITSEIPINMENLPVNNGNGQAFGYVLYE
                     TTIFSSGVLSGLVRDRGQVFLNRVSIGFLDYTTTKITIPLTQGYTILRILVENRGRVN
                     YGNNIDSQRKGLIGNLYLNNKPLKNFKIYSLDMTKQFFQRFDMDKWSVVPKEITFPAF
                     FLGTLSVGIYPSDTFLKLEGWVKGVVLVNDHNLGRYWNVGPQETLYLPGVWLDKGLNK
                     VIIFEETMAGSMVQSTDIPHLGRNQYVN"
     misc_feature    247..1188
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     misc_feature    247..1188
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     exon            129..176
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            177..374
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            375..443
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            444..539
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            540..648
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            649..741
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            742..823
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            824..894
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            895..979
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1117
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1198
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1305
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1446
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1518
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1597
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1685
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1797
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1914
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..3755
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggagtag gaaccccggt gtctaccagc ggctttcgcg cgatgcccaa gtggagcctg
       61 cggcggaggc cgggccgcac actcggactc ctgctgctgc tggtcttgag cttcctggtg
      121 ctccgcaggt atctgaatcc caaggtgggc agctgtgacc gtgaaggggc tctgaggttg
      181 aactggacct ctgtgcttcc cctatggctc caacgtcagc gcctgggact tcgaacaaaa
      241 ggcccaaact tcatgctgga ggactccacc tttcagattt tggggggatc catacactat
      301 ttccgtgtgc ccagggaata ctggagggac cgcctgctca aactgaaagc ctgtggcttg
      361 aataccctta ctacctatgt gccatggaac ctccatgagc cagaacgagg caaattcgac
      421 ttctctggga atctggacct agaggccttt atctggctgg ctgcaaagat tggcctgtgg
      481 gtgattctgc gaccagggcc ctacatctgt agtgagattg acctcggggg cttgcccagc
      541 tggctccttc aagaccctga catgaagcta agaacaactt accctggctt cactaaggca
      601 gtggatcttt actttgacca cctgatgtcc agggtggtgc cgcttcagta taagcatggg
      661 gggcctatca ttgcggtgca agtggagaat gagtacggtt cctataacgg agaccatgcg
      721 tacatgcctt acatcaagaa ggcactggaa gaccgtggca tcattgagat gctcctgacc
      781 tcagacaaca aagatggcct ggaaaaggga gtggttgacg gagtgctggc caccatcaac
      841 ttacagtcac aacaggagct ggtggcacta aacagtattc tcttatctat acaggggatt
      901 caacccaaga tggtgatgga gtactggaca gggtggtttg actcgtgggg tggctcccac
      961 aacatcttgg attcctctga ggtcctgcaa acagtgtctg ccatcatcaa agacggctcc
     1021 tccatcaacc tgtacatgtt ccatggaggc acaaattttg gcttcataaa tggagccatg
     1081 cattttggtg actacaaggc tgatgttacc agctatgact acgatgctat attgacagag
     1141 gctggagatt acactgccaa atacaccaag cttcgagaac tctttggaac cttctcaggc
     1201 gtccctccac ctcctccacc tgagcttact gctaagatgg tctatgagcc agtgactcca
     1261 tctttctacc tgtcactgtg ggacgctctc ctgtacatgg ataagccaat cacatctgag
     1321 atacccatca acatggagaa cctgccggta aacaatggta atgggcaggc ctttgggtat
     1381 gtcctctatg agaccaccat cttttcatct ggcgtcctca gtggccttgt gcgtgacaga
     1441 ggacaggtct ttttgaacag agtgtccata ggattcttgg actatacgac aacgaagatc
     1501 actatcccct tgacccaggg ttacacaata ctgaggatct tggtggagaa tcgtgggcga
     1561 gtcaactacg gaaataacat tgacagccag cgcaaaggtt taattggaaa tctctatctg
     1621 aataataaac ccctgaaaaa cttcaaaatc tacagcctgg atatgacaaa gcagttcttt
     1681 cagaggttcg acatggacaa gtggagtgtc gtacccaaag aaattacctt tcccgctttc
     1741 ttcctgggca ccttgtcagt tggcatttac ccttctgaca catttctgaa gttggagggc
     1801 tgggtgaagg gggttgtgct cgtcaatgat cacaaccttg gacgctactg gaatgtagga
     1861 cctcaggaga ctctctacct ccccggtgtc tggctggaca aaggactcaa caaggttatc
     1921 attttcgaag agacaatggc aggctccatg gtacagtcta ctgatatccc ccacctgggc
     1981 aggaaccagt atgttaactg aacagcagcc cctgcagccc ctgctatggc tggcagcttc
     2041 cttccttcct gtcctgcagg agaagtcatc gtaactagca acctcaggga atgaagggct
     2101 atattcaact caggccaaaa ttctatgcct aagcctaaga gaagatgggg tagcgctgtc
     2161 tgggatacac tcagagtgag atgtcttctc ttctggtttt gtggacgggc attttctgct
     2221 cccctgatct tccaggggag gccacagagc ggccacagag tatgtagtta gttatatcac
     2281 cttcaaagaa ggtgctgagg cgggtgggca ctgccctctt ctggaagtga aagcctcact
     2341 ggccagcctg ctggttctag gtaggctttt tgaacattcc cagcagggtg tggtcacacc
     2401 ctagacagct tctttgtgct cctgaatttg tgggtttgtc attgtttgta gagccaagag
     2461 aaaaggggtc ttatttgagt caactttatt tttttgactt tgcacctgcc agttctgggg
     2521 atctggaaga agtcttttcc tgttctctct gtctcttatt acattaatca gttgataaac
     2581 tgagcctaag agaaacaggc atgttcaatc cagcatgtta gagctgggca cttcagcaga
     2641 aaccacctca catccatgct ctcaggaagg gaatggcaga agacccagcg aggtggtgct
     2701 gggcagctat gcccgactgc agtagaatct ggggttagct agagcacaca ggtctagcac
     2761 cgtccttgtt ttcagctcag ctggtttctt tgaacactcg tcttcccctt cctgaccaaa
     2821 cagcagggag gaggaaaggc agccttctgt cacacacagt ccagactgaa ggctcttgtt
     2881 caaggaatca agtgcaatgg cttggtgtgg tcttgccatt ctaaactgca atacacttga
     2941 agcaaacctt ctttgtgggg tctccagctt ctctgtacca ttctcagcca tggcagaaag
     3001 tgacctttag ggatccagat actgatggta cccagctggc aggtggcaca tgccactggc
     3061 ttcttaccac ctttcctgat tttccttctc cttgaaatgt cattgcacta agagcagtcc
     3121 aatctcatgc tggtggttaa gagtaagaac tttctagaaa gctaaaccac aatatataag
     3181 ttagctatag gggatagttt ttcttcataa attacatctg acatgtactg ctccaagccg
     3241 attgtcttca gtaatagtga aaatcaaata acacacatcc gtgagcatag tgcccacaca
     3301 gaagcctagc gaagatgggt taggcaagag caggcaaaca gagagccttg cagactgaca
     3361 ggccagcttc ctgagtatga ccagggacac tgtagtcagg gctactgcag ccaccgagct
     3421 aagctcccag ctaatgtatc cgcaagtggt catagcggaa cagcccatgt cccactgggt
     3481 ctgcgaaatc gaggttttct gtctgtctgt ctatctgtcc atctctctct ctctctctct
     3541 ctctctctct ctctctctct ctctctctct ctctctctct ctctctcata ttctctcaga
     3601 tggggtcata ttatgtagcc ccgccttgat cttttgtttc tcttgcctta gccttgcaac
     3661 ttctctacca tcatgcccaa ctcaaaggaa gctttttttt tttaaagccc tttatttgtc
     3721 ttaaagtttt aaaataaaat tatgtgataa gtttc
//
LOCUS       NM_001108774            2056 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), transcript variant 5, mRNA.
ACCESSION   NM_001108774 XM_001065048
VERSION     NM_001108774.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001108774.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB720474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984015, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000008.1  96968239-96968307
            70-182              JAXUCZ010000008.1  97006495-97006607
            183-316             JAXUCZ010000008.1  97007968-97008101
            317-416             JAXUCZ010000008.1  97016484-97016583
            417-2056            JAXUCZ010000008.1  97022942-97024581
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2056
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..69
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            70..182
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    163..165
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="upstream in-frame stop codon"
     exon            183..316
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..807
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001102244.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     misc_feature    229..486
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     misc_feature    229..486
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     exon            317..416
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2056
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgaacaca attatgcaaa acctgaatga tgctaaaccc ctgccgaagg gaaggcaagc
       61 ctcagacagg ggaacgactt aattcctgac actggcaggt atctgggccc tggcagttaa
      121 ctctttggac attgtgaatt ggatacgctg tgaagggctc tctgaccagc attgcaaact
      181 aggatggaga tgtctgccca gaggctgact tctaacagaa catccccaca gtcaccatct
      241 aactctgact atacctggga atacgagtac tatgagatcg gaccggtttc cttcgaagga
      301 ctgaaggctc acaaatattc catcgtgatt ggattctggg ttggtcttgc ggtctttgtg
      361 attttcatgt tttttgtgct gactttgctg acaaagacag gcgccccaca ccaagacaat
      421 gcggagtcct cagagaagag gttccgaatg aacagctttg tgtcagactt tgggaagccc
      481 ctggagtcag acaaggtgtt ttctcgtcag ggcaatgagg agtccaggtc tctgttccac
      541 tgttacatca atgaagtgga acacttggac agggttaaag tttgccaccg aacaacagcc
      601 attgacagcg atgtccatct ccaggaagcc atcagaagca gtgggaggcc tgaggaggag
      661 ctaaccaggt ttatgcagtt tgacatcccc aacttcgtga acacagacca gaactccttt
      721 ggggaggatg atcttcttat ttcggaacca cctgttcttc tagaaaataa gccagtttcc
      781 cagacatcac gtacagacct ggactgagac acacttgtgg gtgccttcct gaggatgtgt
      841 tctgtttctg tgcagcaaga aaccacatgc tacctacact tgtgtgtgtg tgtgtggaga
      901 gagagagaga gagagagaga gggagggaga gagagagaga gagagagggg gagggaggag
      961 gcggcagcgg gtggggaaga ggatgatgtt taaagtttaa gacctaggct aggactggga
     1021 tttagtgata gaggggcaga atttgaagat gggaggcacc attttgattt ggggagggtg
     1081 atttttttct ctttggatta aaaatgcctt gacagtatta aagcttcttt attgaaacga
     1141 ttagccaaca catgcaattg agctccctcc tgggtgaggg ctagttcgct gcagtcgggt
     1201 ctagcccttt cccaccatcc tctgcctgta acaagctgct ttgcctctct ggactgccat
     1261 ggctttacag gtaaggtggc ctgtccggag tagatgacct atcccagctc tagaattttg
     1321 tgactttcaa acttagctat aagataagct aagaaacgca taagcagtag aaaataccac
     1381 acggcatcga ggctttcatg gcaggttctt caggtctcgg tgctctccct tcactcagtc
     1441 cttcactggg tcacactttc ggtagggaaa tctttactag gagaccagga gacatgagac
     1501 ttgcacgcac tgtggacagt gtctctgctg ggtgttgcta cagcaattta tgtgctgaac
     1561 gccccccccc cccgctttaa actgggatag cttcgactcc agcgactacc agcccaaact
     1621 gttttcacaa gcatctgtgc tcttgaagaa tggtagagca gattgttatt tggctgatgt
     1681 gagtcccttc tggatgtccc tgtgtttgca tccctgggct cacccttctg aactatttgg
     1741 cttcagaaca ggaagatacc gctcgccatg tctgcgtggc agatgtgtag gtgacggctg
     1801 cctggcttgg agctgagagg gtccgtgggt tttttgccac agtaacagat gttcaggatt
     1861 ggaggatgtt aatatgagcc acatgatgtc cgtctcacaa agcaagcagc cccctttgct
     1921 ggagtcagaa acaacccagt cctgcacaca cagagttgta cgcatgagca gctgctaatc
     1981 tctgggtggc atcttcttta tgaatttgtt caccatttgt cttgcttaag ttgcaaaata
     2041 aatgcatttg atcgca
//
LOCUS       NM_001436554            3285 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 3, mRNA.
ACCESSION   NM_001436554 XM_039081958
VERSION     NM_001436554.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 3285)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039081958.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2147297.1,
                                           SRR21887621.678274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000008.1  60280533-60280738   c
            207-504             JAXUCZ010000008.1  60277553-60277850   c
            505-662             JAXUCZ010000008.1  60271374-60271531   c
            663-762             JAXUCZ010000008.1  60265595-60265694   c
            763-3285            JAXUCZ010000008.1  60261325-60263847   c
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3285
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..206
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1123
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="layilin isoform 3 precursor"
                     /protein_id="NP_001423483.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGQRFCWEGTRRPCYRV
                     IYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGDFWIGLKR
                     LEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPPGIGGPYM
                     FQWNDDRCNTKKNFICKYSDEAALNLAYILIPSIPLFLLLVVTSAVCWVWICRRKREQ
                     TDPPTKEQHTIWPTPHQENSPDLEVYNVIRKQSEADLAEPRPDLKNISFRVCSGEAMP
                     DDTSCDYDNMVINPSESGLVTLASMEGRFVTNDIYEFSPDRMGRSKESGWVENEIYY"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     exon            207..504
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            505..662
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            663..762
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            763..3285
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcgggca gcggttctgc tgggaaggga cacggaggcc
      241 ttgctacaga gtcatttatt tccatgacac ctctcaaaga cggaactttg aggaagcgaa
      301 agaagcctgc atgaaggatg gaggacagct agccagcata gaaacggcag atgagcagag
      361 gctgatagag aacttcattg aaagcctcca ggcatctgat ggtgatttct ggattggcct
      421 caagaggttg gaggagaaac agcacaacag cacagcctgc caggaccttt acgcttggac
      481 agatggaagc ctgtcacagt tcaggaactg gtatatggat gagccttcct gtgagagcga
      541 ggtctgcgtg gtcatgtacc atcagccatc agcacctccg ggcatcgggg gcccatatat
      601 gttccagtgg aatgacgacc ggtgcaacac gaagaagaat ttcatttgca aatattctga
      661 cgaggctgct ttgaatcttg cctacatcct aattcccagt attccccttt tcctcctact
      721 tgtggtcact tcagctgtgt gttgggtttg gatctgtaga agaaaacggg aacagacaga
      781 ccctcccaca aaggagcagc acaccatttg gcccactcct caccaagaga acagccctga
      841 cctagaagtt tacaatgtca tcagaaaaca aagtgaagct gatttagccg agccccggcc
      901 agatctgaag aacatctcct tccgggtgtg ttctggggaa gccatgcccg atgacacgtc
      961 ttgtgactat gacaacatgg ttataaaccc ttctgaaagt gggttagtga ctttggcaag
     1021 tatggagggt agatttgtga ccaatgacat ctatgaattc tcccccgaca gaatggggag
     1081 gagcaaggag agtggatggg tagaaaatga aatatattac taagacatat gaaaaaacca
     1141 gcaagaatgt aaaaagagaa ggaaaagcct ccaatgtctt acaaagacga tattcagaag
     1201 gcttatgaga aggttcagct caggtcttag gggcaagcac agcatcacaa gttccttctg
     1261 ggtccccaag ttctggctgc actccctatc caggaacctc gtccagctca gcctggtcca
     1321 aggcacctca cccaaggggc tgctgcacag cagaccctca gagaaagcca gtggcttcca
     1381 actgacgctc aagagctggt gctttccctg gtcaggatta aggtgtgacc agggagcttg
     1441 gaaagcctac ctctaggctc tgttttcctt gctctgtaca tctgtgcagg caatcacaaa
     1501 gacacaaatg gtgggatcct ctcaaagcct ctgtatggaa gccccaggct ggcctgcaca
     1561 tcaacaattc ccaacctgca tcccaccccc acccctgaaa aaaaaagtca ataaaaagca
     1621 ggaagcagaa tgttagtcag tctgtgtcta cagcccttcc tctgcatgtg gcctcagggg
     1681 agtttttttt ttttttttca ttctcccaac atctaaactt ggaaaagtcc aacttggaaa
     1741 tactttcgaa agtaaaaatg agctctgttt gcttcagagc ttcttcttct ctgggctcag
     1801 acagtatgtg ctgttctggg gatgggtggc agcagcatag gaaactgact gtatacagga
     1861 ctggtgaaaa gagtcgacct agtaaggaaa aggagaggca ggcttctcac tatcagagaa
     1921 ggcagccacg gtcaccagaa gggaggaaac tggaacaggt cctgttgtgt gcaaggggaa
     1981 tcgaaacagt gctgccgtca ttgtggaatt ttatgtactg agtatacata tatatgtatg
     2041 tttatatgtg tatgtatatg tgtgttttcc attaaataag ccagtactcc atgaaactgg
     2101 atgactcaag gacagaagca gaagaaatat gagttactta agtaatgaaa aggaaataat
     2161 gggtatctaa acatagatag aattaacagg tttattgttc tacaggaaca atgaggaccc
     2221 ggatatcaca atgacctata acgtatttat gaataactat gagaaaggag ctcaagggca
     2281 gcaaacacaa agtcatgata aaaatatatt tattgccttg gttgactagt acacattgta
     2341 tatttgtact gttaagtaat accattgtta aaacttaaag agattgggaa tgagaatgtt
     2401 catttgggaa attttacacc accaccaagc aagactgatt aagaatcagc agatagggtt
     2461 ggggatttag ctcagtggta gagtgcttgc ctagcaggcg caaggccctg ggtttggtcc
     2521 ccagctccgg aaaaaaaaaa aaaagagaga gagagagaga aaaaaaaaag aatcagcaga
     2581 tcacagacac caactcgtaa tgatccacct ttggtaatga ggattaattt gaatattaaa
     2641 tcattgaaag taaaaccaac aaagagaatg tgactcaatg ggtaaagtgg gaaaacatgg
     2701 gcatatgctg atacaaaata aaagaataaa ttaaaacttt gatgtagatg gtatatttac
     2761 atgatttcag gtaaagatca ttgattgcaa aagtgaccca acaggcaaag ccacctcagt
     2821 cacctgatga atgtgaattc tgtggacgac gaagtgtact gagattgtag acctcacact
     2881 gtggtgtggt gagagggaca tggcatcaca tccacgctgt ctcacagtgt acaagctgat
     2941 cataaggagg ccttgcataa caacaatttg atggacaatc tacaaactac ctggacggca
     3001 aacctgaact ctgatggtaa agacggtgga agcgagacag gggcagctgc aataggagga
     3061 cagtaaggtg atggctccaa gcgtgaccag atcctgaaat ggatcccttt tctcctgtaa
     3121 aggagaagat gggaacaaat gtggatgacg tctgaggact aaatgtcaaa aacgtgcagt
     3181 gctaacttcc taacttttgc gttgccctga ggacatggcc tcttggcact gggaatgtct
     3241 tcccagaaag cacacagtga agtaataaag gacaatggac tatca
//
LOCUS       NM_001436559            3875 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus galactosidase, beta 1-like 2 (Glb1l2), transcript
            variant 3, mRNA.
ACCESSION   NM_001436559 XM_017595859
VERSION     NM_001436559.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_017595859.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.27725.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000008.1  33442384-33442511   c
            129-176             JAXUCZ010000008.1  33432672-33432719   c
            177-296             JAXUCZ010000008.1  33432396-33432515   c
            297-494             JAXUCZ010000008.1  33432033-33432230   c
            495-563             JAXUCZ010000008.1  33430296-33430364   c
            564-659             JAXUCZ010000008.1  33429601-33429696   c
            660-768             JAXUCZ010000008.1  33427276-33427384   c
            769-861             JAXUCZ010000008.1  33415421-33415513   c
            862-943             JAXUCZ010000008.1  33412669-33412750   c
            944-1014            JAXUCZ010000008.1  33402492-33402562   c
            1015-1099           JAXUCZ010000008.1  33400046-33400130   c
            1100-1237           JAXUCZ010000008.1  33398755-33398892   c
            1238-1318           JAXUCZ010000008.1  33398103-33398183   c
            1319-1425           JAXUCZ010000008.1  33397502-33397608   c
            1426-1566           JAXUCZ010000008.1  33396800-33396940   c
            1567-1638           JAXUCZ010000008.1  33396496-33396567   c
            1639-1717           JAXUCZ010000008.1  33396178-33396256   c
            1718-1805           JAXUCZ010000008.1  33395117-33395204   c
            1806-1917           JAXUCZ010000008.1  33394725-33394836   c
            1918-2034           JAXUCZ010000008.1  33394238-33394354   c
            2035-3875           JAXUCZ010000008.1  33392106-33393946   c
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3875
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="galactosidase, beta 1-like 2"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
     exon            1..128
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2121
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /EC_number="3.2.1.23"
                     /note="isoform 3 is encoded by transcript variant 3;
                     beta-galactosidase-1-like protein 2"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein 2 isoform 3"
                     /protein_id="NP_001423488.1"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
                     /translation="MPKWSLRRRPGRTLGLLLLLVLSFLVLRRYLNPKVGSCDREGAL
                     SLRVFMLNVLSVLFLAAASACSSPAVGPSPGSSNEESHLSRLNWTSVLPLWLQRQRLG
                     LRTKGPNFMLEDSTFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEP
                     ERGKFDFSGNLDLEAFIWLAAKIGLWVILRPGPYICSEIDLGGLPSWLLQDPDMKLRT
                     TYPGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNGDHAYMPYIKKALE
                     DRGIIEMLLTSDNKDGLEKGVVDGVLATINLQSQQELVALNSILLSIQGIQPKMVMEY
                     WTGWFDSWGGSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFGDYK
                     ADVTSYDYDAILTEAGDYTAKYTKLRELFGTFSGVPPPPPPELTAKMVYEPVTPSFYL
                     SLWDALLYMDKPITSEIPINMENLPVNNGNGQAFGYVLYETTIFSSGVLSGLVRDRGQ
                     VFLNRVSIGFLDYTTTKITIPLTQGYTILRILVENRGRVNYGNNIDSQRKGLIGNLYL
                     NNKPLKNFKIYSLDMTKQFFQRFDMDKWSVVPKEITFPAFFLGTLSVGIYPSDTFLKL
                     EGWVKGVVLVNDHNLGRYWNVGPQETLYLPGVWLDKGLNKVIIFEETMAGSMVQSTDI
                     PHLGRNQYVN"
     misc_feature    367..1308
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     misc_feature    367..1308
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     exon            129..176
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            177..296
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            297..494
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            495..563
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            564..659
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            660..768
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            769..861
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            862..943
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1014
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1099
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1237
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1318
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1425
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1566
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1638
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1717
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1805
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1917
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2034
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..3875
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggagtag gaaccccggt gtctaccagc ggctttcgcg cgatgcccaa gtggagcctg
       61 cggcggaggc cgggccgcac actcggactc ctgctgctgc tggtcttgag cttcctggtg
      121 ctccgcaggt atctgaatcc caaggtgggc agctgtgacc gtgaaggggc tctgagccta
      181 cgtgtcttca tgttgaacgt cctgtctgtc ttgttcctgg ctgcagcatc tgcttgctct
      241 tcccctgcag tggggcccag cccaggaagt agtaatgaag aaagtcacct ttcaaggttg
      301 aactggacct ctgtgcttcc cctatggctc caacgtcagc gcctgggact tcgaacaaaa
      361 ggcccaaact tcatgctgga ggactccacc tttcagattt tggggggatc catacactat
      421 ttccgtgtgc ccagggaata ctggagggac cgcctgctca aactgaaagc ctgtggcttg
      481 aataccctta ctacctatgt gccatggaac ctccatgagc cagaacgagg caaattcgac
      541 ttctctggga atctggacct agaggccttt atctggctgg ctgcaaagat tggcctgtgg
      601 gtgattctgc gaccagggcc ctacatctgt agtgagattg acctcggggg cttgcccagc
      661 tggctccttc aagaccctga catgaagcta agaacaactt accctggctt cactaaggca
      721 gtggatcttt actttgacca cctgatgtcc agggtggtgc cgcttcagta taagcatggg
      781 gggcctatca ttgcggtgca agtggagaat gagtacggtt cctataacgg agaccatgcg
      841 tacatgcctt acatcaagaa ggcactggaa gaccgtggca tcattgagat gctcctgacc
      901 tcagacaaca aagatggcct ggaaaaggga gtggttgacg gagtgctggc caccatcaac
      961 ttacagtcac aacaggagct ggtggcacta aacagtattc tcttatctat acaggggatt
     1021 caacccaaga tggtgatgga gtactggaca gggtggtttg actcgtgggg tggctcccac
     1081 aacatcttgg attcctctga ggtcctgcaa acagtgtctg ccatcatcaa agacggctcc
     1141 tccatcaacc tgtacatgtt ccatggaggc acaaattttg gcttcataaa tggagccatg
     1201 cattttggtg actacaaggc tgatgttacc agctatgact acgatgctat attgacagag
     1261 gctggagatt acactgccaa atacaccaag cttcgagaac tctttggaac cttctcaggc
     1321 gtccctccac ctcctccacc tgagcttact gctaagatgg tctatgagcc agtgactcca
     1381 tctttctacc tgtcactgtg ggacgctctc ctgtacatgg ataagccaat cacatctgag
     1441 atacccatca acatggagaa cctgccggta aacaatggta atgggcaggc ctttgggtat
     1501 gtcctctatg agaccaccat cttttcatct ggcgtcctca gtggccttgt gcgtgacaga
     1561 ggacaggtct ttttgaacag agtgtccata ggattcttgg actatacgac aacgaagatc
     1621 actatcccct tgacccaggg ttacacaata ctgaggatct tggtggagaa tcgtgggcga
     1681 gtcaactacg gaaataacat tgacagccag cgcaaaggtt taattggaaa tctctatctg
     1741 aataataaac ccctgaaaaa cttcaaaatc tacagcctgg atatgacaaa gcagttcttt
     1801 cagaggttcg acatggacaa gtggagtgtc gtacccaaag aaattacctt tcccgctttc
     1861 ttcctgggca ccttgtcagt tggcatttac ccttctgaca catttctgaa gttggagggc
     1921 tgggtgaagg gggttgtgct cgtcaatgat cacaaccttg gacgctactg gaatgtagga
     1981 cctcaggaga ctctctacct ccccggtgtc tggctggaca aaggactcaa caaggttatc
     2041 attttcgaag agacaatggc aggctccatg gtacagtcta ctgatatccc ccacctgggc
     2101 aggaaccagt atgttaactg aacagcagcc cctgcagccc ctgctatggc tggcagcttc
     2161 cttccttcct gtcctgcagg agaagtcatc gtaactagca acctcaggga atgaagggct
     2221 atattcaact caggccaaaa ttctatgcct aagcctaaga gaagatgggg tagcgctgtc
     2281 tgggatacac tcagagtgag atgtcttctc ttctggtttt gtggacgggc attttctgct
     2341 cccctgatct tccaggggag gccacagagc ggccacagag tatgtagtta gttatatcac
     2401 cttcaaagaa ggtgctgagg cgggtgggca ctgccctctt ctggaagtga aagcctcact
     2461 ggccagcctg ctggttctag gtaggctttt tgaacattcc cagcagggtg tggtcacacc
     2521 ctagacagct tctttgtgct cctgaatttg tgggtttgtc attgtttgta gagccaagag
     2581 aaaaggggtc ttatttgagt caactttatt tttttgactt tgcacctgcc agttctgggg
     2641 atctggaaga agtcttttcc tgttctctct gtctcttatt acattaatca gttgataaac
     2701 tgagcctaag agaaacaggc atgttcaatc cagcatgtta gagctgggca cttcagcaga
     2761 aaccacctca catccatgct ctcaggaagg gaatggcaga agacccagcg aggtggtgct
     2821 gggcagctat gcccgactgc agtagaatct ggggttagct agagcacaca ggtctagcac
     2881 cgtccttgtt ttcagctcag ctggtttctt tgaacactcg tcttcccctt cctgaccaaa
     2941 cagcagggag gaggaaaggc agccttctgt cacacacagt ccagactgaa ggctcttgtt
     3001 caaggaatca agtgcaatgg cttggtgtgg tcttgccatt ctaaactgca atacacttga
     3061 agcaaacctt ctttgtgggg tctccagctt ctctgtacca ttctcagcca tggcagaaag
     3121 tgacctttag ggatccagat actgatggta cccagctggc aggtggcaca tgccactggc
     3181 ttcttaccac ctttcctgat tttccttctc cttgaaatgt cattgcacta agagcagtcc
     3241 aatctcatgc tggtggttaa gagtaagaac tttctagaaa gctaaaccac aatatataag
     3301 ttagctatag gggatagttt ttcttcataa attacatctg acatgtactg ctccaagccg
     3361 attgtcttca gtaatagtga aaatcaaata acacacatcc gtgagcatag tgcccacaca
     3421 gaagcctagc gaagatgggt taggcaagag caggcaaaca gagagccttg cagactgaca
     3481 ggccagcttc ctgagtatga ccagggacac tgtagtcagg gctactgcag ccaccgagct
     3541 aagctcccag ctaatgtatc cgcaagtggt catagcggaa cagcccatgt cccactgggt
     3601 ctgcgaaatc gaggttttct gtctgtctgt ctatctgtcc atctctctct ctctctctct
     3661 ctctctctct ctctctctct ctctctctct ctctctctct ctctctcata ttctctcaga
     3721 tggggtcata ttatgtagcc ccgccttgat cttttgtttc tcttgcctta gccttgcaac
     3781 ttctctacca tcatgcccaa ctcaaaggaa gctttttttt tttaaagccc tttatttgtc
     3841 ttaaagtttt aaaataaaat tatgtgataa gtttc
//
LOCUS       NM_001436543            1672 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus triosephosphate isomerase 1 like 1 (Tpi1l1),
            transcript variant 2, mRNA.
ACCESSION   NM_001436543 XM_039081927
VERSION     NM_001436543.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039081927.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1837491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000008.1  31931100-31931249   c
            151-315             JAXUCZ010000008.1  31930140-31930304   c
            316-365             JAXUCZ010000008.1  31927901-31927950   c
            366-1672            JAXUCZ010000008.1  31923596-31924902   c
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1672
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase 1 like 1"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
     exon            1..150
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..315
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    292..294
                     /gene="Tpi1l1"
                     /note="upstream in-frame stop codon"
     exon            316..365
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1101
                     /gene="Tpi1l1"
                     /EC_number="5.3.1.1"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="triosephosphate isomerase 1 like 1 isoform 1"
                     /protein_id="NP_001423472.1"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
                     /translation="MTIMELNSRKFFVGGNWKMNGKKKCLGELICTLNAAKMPADTEV
                     VCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSE
                     RRHVFGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVK
                     DWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEEVAQCTRIIYGGSVT
                     GATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ"
     misc_feature    361..1092
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    361..1092
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    order(385..387,391..393,637..639,847..849,865..867,
                     985..987,1042..1044,1048..1053)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(385..387,391..393,637..639,847..849,865..867,
                     985..987,1042..1044,1048..1053)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(385..387,394..396,487..495,499..501,508..510,
                     544..546,598..600,607..612,643..648)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(385..387,394..396,487..495,499..501,508..510,
                     544..546,598..600,607..612,643..648)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(391..393,637..639,847..849)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
     misc_feature    order(391..393,637..639,847..849)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
     exon            366..1672
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcagta gacgccttca gcacacaaga caaggtctct cggcagactg cagcctcttc
       61 actctggtcc acagcactgg tcctctcacc tctgtgcttt agaatccaga agattccaga
      121 tgccagtggg gcacattcaa cttgaacaag gaatttaagt aaagaattgt agaaatagaa
      181 ggtatttcta ctacattaag aaggtaagca cttttttttt tcttttttct ttttttcgga
      241 gctcgggacc gaacccaggg ccttgcgctt gctaggcaag tgctctacca ctgagctaaa
      301 tccccaaccc cgaagatacc cggatccttt aaccttccga tgactattat ggaacttaat
      361 tcaaggaagt tcttcgtcgg gggcaactgg aagatgaacg ggaagaagaa atgcctggga
      421 gaactcatct gcaccctgaa cgcagccaag atgccggcag acaccgaggt ggtttgtgca
      481 ccgccaaccg cctacatcga cttcgccagg cagaagctgg atcccaaaat tgctgtggct
      541 gcacagaact gctacaaagt gaccaatggg gctttcactg gggaaatcag ccctggcatg
      601 atcaaagact taggagctac ctgggtggtg ctgggacact cggaaagaag acacgtcttt
      661 ggggaatcag acgagttgat tgggcagaaa gtgaaccatg ccctatccga gggactcgga
      721 gtgatcgcct gcattgggga gaagttagac gaaagggaag ctggcatcac tgagaaggtt
      781 gtttttgagc aaaccaaggc catcgcagat aatgtgaagg actggtccaa ggtggtcctg
      841 gcctatgaac cggtatgggc cattgggact ggcaagactg caacccctca acaggcccag
      901 gaagtacacg agaagctccg gggatggctg aagtgcaacg tctctgagga ggtggctcag
      961 tgcactcgga tcatttatgg aggttctgtg actggagcga cttgcaaaga gctggcaagc
     1021 cagcctgatg tggatggctt cctcgtgggc ggtgcatctc tcaagcctga attcgtggac
     1081 attatcaatg ccaaacaatg agcactgctc atccccctac cttcctgcgt agcctggacc
     1141 aggttgccca gaagtttagt aactgctccc gccagtcaca tgcttctgat gacatcatca
     1201 actccatcct gtgacctatt ccatactgta ccttcctgag cctcttacct ccccataata
     1261 gttgggacca ggccaatccc tttaccactt acaatgggta aaatcaaata tgtcaccaag
     1321 atggcttcct gaggagggga aggagtagaa ctggcagtcc ctttgggccc taatgggtga
     1381 aaacggcctt ccattggttt gggatggaaa ctcatggctg gaccacagga agtaggcttc
     1441 ttgtcacttt ggcctgtcac ttagatggcc ttggctctag cttcactccc aagccctact
     1501 ggatgtgtga tgcagagatt cagagtcttc aggtctgaat ttcagtgtac attaaggcca
     1561 agatcctctt actcttagag gcctgggata tcccctcccc cgcagtgcca aagcccttgt
     1621 attgtgtttg tgaaccatcc tacgtataag ggaaataaac acctgggcct aa
//
LOCUS       NM_001109290            3641 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus zinc finger protein 202 (Zfp202), transcript
            variant 1, mRNA.
ACCESSION   NM_001109290 XM_001059357 XM_576391
VERSION     NM_001109290.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3641)
  AUTHORS   Wagner,S., Hess,M.A., Ormonde-Hanson,P., Malandro,J., Hu,H.,
            Chen,M., Kehrer,R., Frodsham,M., Schumacher,C., Beluch,M.,
            Honer,C., Skolnick,M., Ballinger,D. and Bowen,B.R.
  TITLE     A broad role for the zinc finger protein ZNF202 in human lipid
            metabolism
  JOURNAL   J Biol Chem 275 (21), 15685-15690 (2000)
   PUBMED   10748193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001109290.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.27953.1,
                                           SRR26360186.310913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000008.1  49439867-49439976
            111-612             JAXUCZ010000008.1  49454165-49454666
            613-823             JAXUCZ010000008.1  49455265-49455475
            824-912             JAXUCZ010000008.1  49455771-49455859
            913-1042            JAXUCZ010000008.1  49456674-49456803
            1043-1162           JAXUCZ010000008.1  49457345-49457464
            1163-3641           JAXUCZ010000008.1  49457801-49460279
FEATURES             Location/Qualifiers
     source          1..3641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3641
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="zinc finger protein 202"
                     /db_xref="GeneID:500981"
                     /db_xref="RGD:1562294"
     exon            1..110
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            111..612
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="upstream in-frame stop codon"
     CDS             205..2136
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /codon_start=1
                     /product="zinc finger protein 202"
                     /protein_id="NP_001102760.1"
                     /db_xref="GeneID:500981"
                     /db_xref="RGD:1562294"
                     /translation="MATALELEDQDLWEEEEEGVLMVKLEDDFTCGPESALQGDDPVL
                     ETSHQNFRCFRYQEASSPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPG
                     ELQSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVQGQEVLSEETLHLGVEPES
                     SNEQQEPTQTLTAEQPHEEALRSTDLGTLEQESLQHEGERLPLLESEVPVSQHADLPT
                     EQGSGHPEMVALLTALSQGLVTFKDVALCFSQDQWSDLDPTQKEFYGEYVLEEDCGIV
                     VSLSFPIPRLDDPSQIREEEPQVPGVHESQEPAEPEILSFTYTGDMSEAEEECVEQQD
                     TNKSILANTEIHQTPDWEIVIEDNTSRLNERFGTNVSKVNSFTNIRKTMPVHSQSGRQ
                     HHCPLCAKSFTCNSHLIRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKVNTPHK
                     HPPNRKTVDASQVQSEATTRVEKPYTCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTIC
                     GKSFSQKSVLTTHQRIHVGGKPYTCANCGENFSEQKQYLAHRKTHVSEENHLCSECGR
                     SFNHSAAFAKHLKGHASVRNCRCDECGKSFSRRDHLVRHQRTHTGEKPFTCATCGKSF
                     SRGYHLIRHQRIHTGKTKT"
     misc_feature    337..669
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    337..669
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    919..1101
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    919..1101
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    <1204..2082
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <1204..2082
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1387..1449
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1387..1449
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1402..1404,1408..1410,1414..1416,1420..1425,
                     1432..1437,1444..1446,1486..1488,1492..1494,1504..1509,
                     1516..1521,1528..1530,1648..1650,1654..1656,1660..1662,
                     1666..1671,1678..1683,1690..1692)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1402..1404,1408..1410,1414..1416,1420..1425,
                     1432..1437,1444..1446,1486..1488,1492..1494,1504..1509,
                     1516..1521,1528..1530,1648..1650,1654..1656,1660..1662,
                     1666..1671,1678..1683,1690..1692)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1471..1533
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1471..1533
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1633..1695
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1633..1695
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1717..1779
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1717..1779
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1801..1863
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1801..1863
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1885..1947
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1885..1947
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1900..1902,1906..1908,1912..1914,1918..1923,
                     1930..1935,1942..1944,1984..1986,1990..1992,2002..2007,
                     2014..2019,2026..2028,2068..2070,2074..2076,2080..2082,
                     2086..2091,2098..2103,2110..2112)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1900..1902,1906..1908,1912..1914,1918..1923,
                     1930..1935,1942..1944,1984..1986,1990..1992,2002..2007,
                     2014..2019,2026..2028,2068..2070,2074..2076,2080..2082,
                     2086..2091,2098..2103,2110..2112)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1969..2031
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1969..2031
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2053..2115
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2053..2115
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            613..823
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            824..912
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1042
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1162
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..3641
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttccgac ccgctgggcc ccgcgcgact cggatcccgc tccgctcttt tggccgggag
       61 tgggtggggg agcaccgggc aggggaggag ccgctggagc cgcgggagac gtcccttagg
      121 aggaacccct tgaggtaccc ggtctagaat acattaatgc ccttgtgagt gctaaatggt
      181 gtgataacac ccaagagcca ggaaatggcg acagccttgg agctagagga ccaagatctt
      241 tgggaagaag aagaagaagg agttctgatg gtgaaactgg aggatgattt cacctgcggg
      301 ccagaatctg ccttgcaggg cgatgatcct gtactggaga cctctcacca gaatttccga
      361 tgctttcgct accaggaagc atctagccct cgagaagccc tcatcagact tcgagagctt
      421 tgtcatcaat ggttgaggcc agagaggaga acaaaggagc agatccttga gctgcttgtg
      481 ctagaacagt tcctcactgt cctacctgga gaactgcaga gctgggtgcg aggccaacgg
      541 ccagagagtg gcgaggaggc agtgacgctg gtggagggtt tgcagaaaca acccaggaga
      601 ccaaggcggt gggtaaccgt ccatgttcaa ggccaggaag ttctgtcaga ggagacacta
      661 cacctagggg tggagccaga gtcctccaat gagcagcaag agccaacaca gaccttgacc
      721 gctgagcagc cccatgagga agccctccga agcacagatc tggggacact ggaacaggag
      781 agcttgcagc atgaagggga gcgcctgccc ctgctggaaa gtgaggttcc agtgtcccag
      841 catgcagacc ttcccacaga acaagggtct ggacacccag agatggttgc tcttctcact
      901 gctctctctc agggactggt cacattcaag gatgtggctc tgtgcttctc acaagatcaa
      961 tggagtgatc tggatccaac acaaaaagaa ttctatggag aatatgtctt ggaagaagat
     1021 tgtggaattg tggtctctct gtcatttcca attcccagac tagatgatcc ctcccagatt
     1081 agagaagaag agcctcaggt cccaggagtc catgaatctc aagaacctgc agaaccagaa
     1141 atcctgagtt ttacctatac aggagacatg agtgaagccg aggaagaatg tgttgagcaa
     1201 caagatacaa acaagtctat tttggcaaac acagaaattc accagactcc agattgggaa
     1261 atagtcattg aggataatac cagtagactt aatgaaagat ttggtacaaa tgtttctaaa
     1321 gtcaatagct tcacaaatat taggaaaact atgcctgtcc actcccagtc agggagacag
     1381 catcattgcc ctctatgtgc aaaaagcttc acatgtaatt ctcatcttat taggcactta
     1441 agaactcaca caggagaaaa accctataaa tgtatggagt gtgggaaaag ttacacacgg
     1501 agttcacatc tagcgaggca ccagaaagtc cataaggtga acactcctca taaacatcct
     1561 ccaaaccgga agactgtgga tgcctctcaa gtccagtctg aggcaactac ccgtgtggag
     1621 aaaccatata cctgtgatga ttgtggaaag cacttccgtt ggacatcgga cctggtcagg
     1681 caccagagga cacatacagg agaaaaacct tttttctgca ctatttgtgg caaaagcttc
     1741 agccagaaat ctgtgttaac aacacaccaa agaatccatg ttggaggcaa gccctacaca
     1801 tgtgcgaact gtggagaaaa cttcagtgag cagaaacagt atctggcaca ccggaagaca
     1861 catgtgtctg aggagaacca tctctgcagt gagtgtgggc gctccttcaa ccatagtgct
     1921 gcgtttgcca agcacctgaa aggccacgct tcagtgagga actgccggtg tgatgaatgt
     1981 ggtaaaagct ttagcaggag ggatcacctt gtcagacatc aacgaacaca cactggggaa
     2041 aagcctttta cctgtgctac ctgtggaaaa agtttcagca gaggatatca cttaatccgc
     2101 catcagagaa tccacacagg aaagaccaag acctagctag gggccatatg tggagagctt
     2161 aattcagcag caaactgaga tgggatgggt tctgtgctca acctgagaag aacttttgta
     2221 aggcgtctct ttgatctgcc cataccttat gtcacctctt ctaactacca aacaaaagcc
     2281 ccatccagaa ctactcaact tttctcagtt gaggcttctg tttcactggc atgctcctgc
     2341 ctctgcctca tgggtgtgat ctaggagata tgggacttaa ggaaatttgg gtcattatat
     2401 tttgagaaac gtaggctgct ctagatcctg gagactactt aacagcctca acttcagtgt
     2461 ggtcaaggat aaggacctag gtctgataaa caaccaacct taaagggtct gtccttactg
     2521 ggctcaaacc ttaaggcacg cagccctaaa ctcaagatag gaggtttggg tgctgataga
     2581 tttgccacac actgacggga tagctacaga ttcctcacta actcgcctct tcactgtaca
     2641 ctttccttca atgctggaga caaaggggaa gagttttgaa ggacaaatcc ttaaggctcc
     2701 tccacaagga ttttgacagg ctgctccttt ccccattgtc agaatgacac taagtgccac
     2761 acactgctac aaaagcgggc ctaatcaaaa gcctcttggg gtgcaccaca cctgtctaca
     2821 tactcctgtc tttagctttt ctactattca gccactgtca gtttgtccct tacatgccta
     2881 ctgcaaaaga gatgtagtcc tggagtgctg aagaattcag taaagcataa ttaagacatg
     2941 gtgaaatcca ttacattccc acataatgtt taagcgtgtc ctttatttgg cttgtaagaa
     3001 gggatctgaa gctcttgtta gcgtagaaag gcactgtatc cagtgcagaa tcctaattga
     3061 ctgaggaaaa ctagagaaga tataaaacac tttggaagac tatgaaacag ttgttgccac
     3121 tggccaagac tgttaggact gttctgacac ctagtccttg gtatgcctgc ctcggttttt
     3181 taatgtctgg gaagattatg aaccctagta cttgggaccc tgagaattaa tcggaagtaa
     3241 agggattttt atgcgtctgt gttacttggt ttttaatgtg taagtgtttt catgtaattg
     3301 tgaactgaaa agtagtatct cctggtggcc tatgggtctt ttgcctgttc aaagttccca
     3361 ggaggctgaa attttatgaa ccttacatgt ctggtcatct gaaaaggact gaggacagat
     3421 acttgataga cagagcccag gatgtgggat taaagaatgg gaaggcagat acacttctat
     3481 gcctgatttc ttctgcttat ttcacaatca cagaggaata tggtgagtta gcaagtcatc
     3541 ttcccagctc taatatccca atagggaatc ctctcatgat gaagccagtc aatcgttgtc
     3601 atgaagatac ataaataaat aaagtgatac ttacagccaa a
//
LOCUS       NM_001108786            2873 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus cysteine and serine rich nuclear protein 1
            (Csrnp1), transcript variant 4, mRNA.
ACCESSION   NM_001108786 XM_001077652 XM_343504
VERSION     NM_001108786.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2873)
  AUTHORS   Ye,X., Lin,J., Lin,Z., Xue,A., Li,L., Zhao,Z., Liu,L., Shen,Y. and
            Cong,B.
  TITLE     Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes
            apoptosis through activating Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 359 (2), 441-448 (2017)
   PUBMED   28830684
  REMARK    GeneRIF: Axud1 mediated stress-induced cardiomyocytes apoptosis
            through activating Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 2873)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2873)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001108786.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360186.1327846.1, SRR26643299.37802.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN06680413,
                                    SAMN06680414 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000008.1  128588400-128588469 c
            71-306              JAXUCZ010000008.1  128588091-128588326 c
            307-566             JAXUCZ010000008.1  128585270-128585529 c
            567-881             JAXUCZ010000008.1  128584548-128584862 c
            882-2873            JAXUCZ010000008.1  128582364-128584355 c
FEATURES             Location/Qualifiers
     source          1..2873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2873
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="cysteine and serine rich nuclear protein 1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
     exon            1..70
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..306
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1856
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="AXIN1 up-regulated 1"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1"
                     /protein_id="NP_001102256.1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
                     /translation="MAGIQKRKFDQLEEDDCSSSSLSSGDLSPSPPSSSASPAWTSEE
                     EGLGDQPPQPDQDSSGIQSLMPPSILKRAPRERPGHVAFDGITVYYFPRCQGFTSVPS
                     HGGCTLGMASRHSTCRLFSLAEFKQEQFRARREKLRRRLKEEKLEMLKWKLSVSGVPE
                     AGADVPLTVDAIDDASVEEDLAVAVAGGRLEEANFLQPYPPRQRRALLRASGVRRIDR
                     EEKRELQALRQSREDCGCHCDGVCDPETCSCILAGIKCQMDHTSFPCGCCSEGCENPH
                     GRVEFNQARVQTHFIHTLTRLQMEQGAESLGDPESPMEDVPVEQTVVSPFPPSKPTMS
                     NDLGDSSCGSDMTDSSTTYSSGGSGSRSEAPNHLAHPSLPGSSFRSGIDEDSLEQILN
                     FSDSDLGIEEEEEEGGSVGNLDNLSCFHLADIFGTGDPGSLASWTHSQFGSSLPSGIL
                     DENANLDASCFLSSGLEGLREGSLPSSSGSPEGEAAQSSSLDLSLSSCDSFELLQSLP
                     DYSLGPHYTSRRVSGSLDSLETFHPSPSFSPPRDASFLDSLIGLSEPVTDVLAPLLES
                     QFEDTAVVPLDPVPV"
     misc_feature    339..1013
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     misc_feature    339..1013
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     exon            307..566
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..881
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..2873
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagactgta ctggagacac taccatgaac ccgggctgga gggttcagag tctgggagat
       61 accctggaag gccgtctgtc ctcagctgct tggaacccct acatcccacc atggctggga
      121 tacagaagag gaagtttgac cagctggaag aggacgactg cagctcctcc tccttgtcct
      181 ctggcgatct ctctccctct cctcccagct cttctgcctc ccctgcctgg acctctgagg
      241 aggagggact gggtgatcag ccaccccagc ctgatcagga ctccagtggc atccagagtt
      301 taatgccccc atccatcctg aagcgggctc ctcgggagcg tccgggtcac gtggccttcg
      361 atggcatcac tgtctactat ttcccgcggt gccagggatt caccagtgtg cccagccatg
      421 gtggctgtac cctgggcatg gcttctcgtc atagcacctg ccgcctcttc tccttagccg
      481 agtttaaaca ggagcagttc cgggctcggc gtgagaagct ccgtcggcgt ttaaaggagg
      541 agaagctaga gatgctgaaa tggaagcttt cagtgtccgg agttccggag gcaggggcag
      601 acgtgccgct cacagtggac gccatcgatg acgcttctgt agaggaggac ttggcagtgg
      661 ccgtggcagg tggccgcctg gaggaagcga atttcctaca gccctatcca cctcggcagc
      721 gacgggccct acttcgcgct tccggtgttc gaaggattga ccgagaggag aagcgcgagc
      781 tgcaggcgct acgccaatcc cgggaggatt gtggttgtca ctgtgatggc gtctgtgacc
      841 ctgagacctg cagttgcatc ctggccggca ttaaatgcca gatggatcac acgtccttcc
      901 cctgtggctg ctgcagcgag ggctgtgaga acccccatgg tcgagtggaa ttcaatcagg
      961 cgagagttca gacacacttc atccacacgc tcacccgcct gcagatggag cagggtgcgg
     1021 agagtttggg ggacccggag tcccccatgg aggacgttcc tgtcgaacaa accgtggttt
     1081 ccccctttcc tccttccaaa cccactatga gcaatgacct gggggacagc agctgtggca
     1141 gcgacatgac agactcttcc acgacctact cctctggcgg cagtggcagc cgcagcgagg
     1201 ctccgaacca tcttgcccac cccagcctgc caggttccag cttccggtct ggcatagatg
     1261 aagacagcct ggaacagatc ctgaatttca gtgactctga cctcggtatt gaggaagaag
     1321 aggaggaggg agggagtgtg ggcaacttgg ataacctcag ctgttttcat ttggctgaca
     1381 tctttggtac cggtgacccc ggcagcctgg ctagctggac acacagccag tttggctcta
     1441 gccttccatc gggcatccta gatgagaatg ccaacctgga cgccagctgc ttcctaagca
     1501 gcggactcga agggttgaga gaaggtagcc tccccagcag ttctgggtcc cctgaggggg
     1561 aagccgccca gagcagctcc ttggacctca gtttatcctc ctgtgactcc tttgagcttc
     1621 tccaatctct gccagattat agtctggggc ctcactatac ttcccgaagg gtatctggca
     1681 gcctggacag ccttgagacc ttccaccctt cgcccagctt ctctccaccg agggatgcca
     1741 gcttcctgga ttctctcata ggcctgtctg agccggttac agatgtcctg gcgccccttc
     1801 tggagagcca gtttgaggac actgctgtgg tgcctttgga ccctgtgcct gtgtaaggat
     1861 tgagatgact ttttcctgcc ctgagaccct gttgctgctt tttatgtgat cttggtgtcc
     1921 cccaaggtct gtgtatgtaa cggtctcccg tgggctggtt ctgcccccgt gccatgtggg
     1981 caatcctcta tttttacagt aacactctag atttatttat ttttttatgt ttttctgtac
     2041 tgaagggagg gtgggaaggg tatccctctt tcaatgcctg gcctctatgt ccaaacagag
     2101 gtctcccacc tcctactgta tgcctggagg aggaaggggc agggttcaca tcccctcttt
     2161 ctgtactgta aaatgctcct tggtccaaag acagctgaaa agcaggcctt agggtttcct
     2221 gtggaccgtg ggagctaggt cttctggact gtgaagatgt aatttatttc tgtaatttat
     2281 ttggggactg agacagcagt ggttgggcct ctctggcagg tgggcggtgt tgaggcaaag
     2341 tcttcggtgt cccccgccgg tctgggcttc ggtgtggcgt gtaggttcga gctgagcaga
     2401 cggaggctgt gcttgaccat cggtgatcaa aactccctct gccccctgcc cagacgctct
     2461 aacatgccct ctgtccattt ccctctcccc aaggccatgg gttataaagg ccctatgtag
     2521 gatggggagc cagaggccct aagacatgaa gcacacccca gatcactgtc tctagccttt
     2581 ctgggcactg aatccatcct gacccaccac acaccccccg gccagttggc aagaaagagg
     2641 tggctcttgg gggcttttat gcccttcatt agctgatgtt ggattttata tgcattttta
     2701 tattgtctct aagtgtcaga actataattt attcatttct ctgtgtgtgt gtgtgccaag
     2761 aaacgcaggc tctgggcctg cctccttgcc caggaggcct tgccagcctg tgtgcttgtg
     2821 agaacacatt gtacctgagc tgacaggtac caataaagac actctatttt taa
//
LOCUS       NM_001436553            3321 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 2, mRNA.
ACCESSION   NM_001436553 XM_063265987
VERSION     NM_001436553.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_063265987.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.622379.1,
                                           SRR21887621.972806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345331,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000008.1  60280533-60280738   c
            207-504             JAXUCZ010000008.1  60277553-60277850   c
            505-662             JAXUCZ010000008.1  60271374-60271531   c
            663-698             JAXUCZ010000008.1  60267495-60267530   c
            699-798             JAXUCZ010000008.1  60265595-60265694   c
            799-3321            JAXUCZ010000008.1  60261325-60263847   c
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3321
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..206
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1159
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="layilin isoform 2 precursor"
                     /protein_id="NP_001423482.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGQRFCWEGTRRPCYRV
                     IYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGDFWIGLKR
                     LEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPPGIGGPYM
                     FQWNDDRCNTKKNFICKYSDDKPSTTPSLSPGEAALNLAYILIPSIPLFLLLVVTSAV
                     CWVWICRRKREQTDPPTKEQHTIWPTPHQENSPDLEVYNVIRKQSEADLAEPRPDLKN
                     ISFRVCSGEAMPDDTSCDYDNMVINPSESGLVTLASMEGRFVTNDIYEFSPDRMGRSK
                     ESGWVENEIYY"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153057"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153057"
     exon            207..504
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            505..662
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            663..698
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            699..798
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            799..3321
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcgggca gcggttctgc tgggaaggga cacggaggcc
      241 ttgctacaga gtcatttatt tccatgacac ctctcaaaga cggaactttg aggaagcgaa
      301 agaagcctgc atgaaggatg gaggacagct agccagcata gaaacggcag atgagcagag
      361 gctgatagag aacttcattg aaagcctcca ggcatctgat ggtgatttct ggattggcct
      421 caagaggttg gaggagaaac agcacaacag cacagcctgc caggaccttt acgcttggac
      481 agatggaagc ctgtcacagt tcaggaactg gtatatggat gagccttcct gtgagagcga
      541 ggtctgcgtg gtcatgtacc atcagccatc agcacctccg ggcatcgggg gcccatatat
      601 gttccagtgg aatgacgacc ggtgcaacac gaagaagaat ttcatttgca aatattctga
      661 cgataaacca agtacaacac cctctcttag tcctggagag gctgctttga atcttgccta
      721 catcctaatt cccagtattc cccttttcct cctacttgtg gtcacttcag ctgtgtgttg
      781 ggtttggatc tgtagaagaa aacgggaaca gacagaccct cccacaaagg agcagcacac
      841 catttggccc actcctcacc aagagaacag ccctgaccta gaagtttaca atgtcatcag
      901 aaaacaaagt gaagctgatt tagccgagcc ccggccagat ctgaagaaca tctccttccg
      961 ggtgtgttct ggggaagcca tgcccgatga cacgtcttgt gactatgaca acatggttat
     1021 aaacccttct gaaagtgggt tagtgacttt ggcaagtatg gagggtagat ttgtgaccaa
     1081 tgacatctat gaattctccc ccgacagaat ggggaggagc aaggagagtg gatgggtaga
     1141 aaatgaaata tattactaag acatatgaaa aaaccagcaa gaatgtaaaa agagaaggaa
     1201 aagcctccaa tgtcttacaa agacgatatt cagaaggctt atgagaaggt tcagctcagg
     1261 tcttaggggc aagcacagca tcacaagttc cttctgggtc cccaagttct ggctgcactc
     1321 cctatccagg aacctcgtcc agctcagcct ggtccaaggc acctcaccca aggggctgct
     1381 gcacagcaga ccctcagaga aagccagtgg cttccaactg acgctcaaga gctggtgctt
     1441 tccctggtca ggattaaggt gtgaccaggg agcttggaaa gcctacctct aggctctgtt
     1501 ttccttgctc tgtacatctg tgcaggcaat cacaaagaca caaatggtgg gatcctctca
     1561 aagcctctgt atggaagccc caggctggcc tgcacatcaa caattcccaa cctgcatccc
     1621 acccccaccc ctgaaaaaaa aagtcaataa aaagcaggaa gcagaatgtt agtcagtctg
     1681 tgtctacagc ccttcctctg catgtggcct caggggagtt tttttttttt ttttcattct
     1741 cccaacatct aaacttggaa aagtccaact tggaaatact ttcgaaagta aaaatgagct
     1801 ctgtttgctt cagagcttct tcttctctgg gctcagacag tatgtgctgt tctggggatg
     1861 ggtggcagca gcataggaaa ctgactgtat acaggactgg tgaaaagagt cgacctagta
     1921 aggaaaagga gaggcaggct tctcactatc agagaaggca gccacggtca ccagaaggga
     1981 ggaaactgga acaggtcctg ttgtgtgcaa ggggaatcga aacagtgctg ccgtcattgt
     2041 ggaattttat gtactgagta tacatatata tgtatgttta tatgtgtatg tatatgtgtg
     2101 ttttccatta aataagccag tactccatga aactggatga ctcaaggaca gaagcagaag
     2161 aaatatgagt tacttaagta atgaaaagga aataatgggt atctaaacat agatagaatt
     2221 aacaggttta ttgttctaca ggaacaatga ggacccggat atcacaatga cctataacgt
     2281 atttatgaat aactatgaga aaggagctca agggcagcaa acacaaagtc atgataaaaa
     2341 tatatttatt gccttggttg actagtacac attgtatatt tgtactgtta agtaatacca
     2401 ttgttaaaac ttaaagagat tgggaatgag aatgttcatt tgggaaattt tacaccacca
     2461 ccaagcaaga ctgattaaga atcagcagat agggttgggg atttagctca gtggtagagt
     2521 gcttgcctag caggcgcaag gccctgggtt tggtccccag ctccggaaaa aaaaaaaaaa
     2581 gagagagaga gagagaaaaa aaaaagaatc agcagatcac agacaccaac tcgtaatgat
     2641 ccacctttgg taatgaggat taatttgaat attaaatcat tgaaagtaaa accaacaaag
     2701 agaatgtgac tcaatgggta aagtgggaaa acatgggcat atgctgatac aaaataaaag
     2761 aataaattaa aactttgatg tagatggtat atttacatga tttcaggtaa agatcattga
     2821 ttgcaaaagt gacccaacag gcaaagccac ctcagtcacc tgatgaatgt gaattctgtg
     2881 gacgacgaag tgtactgaga ttgtagacct cacactgtgg tgtggtgaga gggacatggc
     2941 atcacatcca cgctgtctca cagtgtacaa gctgatcata aggaggcctt gcataacaac
     3001 aatttgatgg acaatctaca aactacctgg acggcaaacc tgaactctga tggtaaagac
     3061 ggtggaagcg agacaggggc agctgcaata ggaggacagt aaggtgatgg ctccaagcgt
     3121 gaccagatcc tgaaatggat cccttttctc ctgtaaagga gaagatggga acaaatgtgg
     3181 atgacgtctg aggactaaat gtcaaaaacg tgcagtgcta acttcctaac ttttgcgttg
     3241 ccctgaggac atggcctctt ggcactggga atgtcttccc agaaagcaca cagtgaagta
     3301 ataaaggaca atggactatc a
//
LOCUS       NM_001436535            2926 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus cysteine and serine rich nuclear protein 1
            (Csrnp1), transcript variant 3, mRNA.
ACCESSION   NM_001436535
VERSION     NM_001436535.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Ye,X., Lin,J., Lin,Z., Xue,A., Li,L., Zhao,Z., Liu,L., Shen,Y. and
            Cong,B.
  TITLE     Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes
            apoptosis through activating Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 359 (2), 441-448 (2017)
   PUBMED   28830684
  REMARK    GeneRIF: Axud1 mediated stress-induced cardiomyocytes apoptosis
            through activating Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.32629.1,
                                           SRR26643299.37801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840115,
                                           SAMN12840117 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000008.1  128594684-128594806 c
            124-359             JAXUCZ010000008.1  128588091-128588326 c
            360-619             JAXUCZ010000008.1  128585270-128585529 c
            620-934             JAXUCZ010000008.1  128584548-128584862 c
            935-2926            JAXUCZ010000008.1  128582364-128584355 c
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2926
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="cysteine and serine rich nuclear protein 1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
     exon            1..123
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    116..118
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="upstream in-frame stop codon"
     exon            124..359
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1909
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="AXIN1 up-regulated 1"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1"
                     /protein_id="NP_001423464.1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
                     /translation="MAGIQKRKFDQLEEDDCSSSSLSSGDLSPSPPSSSASPAWTSEE
                     EGLGDQPPQPDQDSSGIQSLMPPSILKRAPRERPGHVAFDGITVYYFPRCQGFTSVPS
                     HGGCTLGMASRHSTCRLFSLAEFKQEQFRARREKLRRRLKEEKLEMLKWKLSVSGVPE
                     AGADVPLTVDAIDDASVEEDLAVAVAGGRLEEANFLQPYPPRQRRALLRASGVRRIDR
                     EEKRELQALRQSREDCGCHCDGVCDPETCSCILAGIKCQMDHTSFPCGCCSEGCENPH
                     GRVEFNQARVQTHFIHTLTRLQMEQGAESLGDPESPMEDVPVEQTVVSPFPPSKPTMS
                     NDLGDSSCGSDMTDSSTTYSSGGSGSRSEAPNHLAHPSLPGSSFRSGIDEDSLEQILN
                     FSDSDLGIEEEEEEGGSVGNLDNLSCFHLADIFGTGDPGSLASWTHSQFGSSLPSGIL
                     DENANLDASCFLSSGLEGLREGSLPSSSGSPEGEAAQSSSLDLSLSSCDSFELLQSLP
                     DYSLGPHYTSRRVSGSLDSLETFHPSPSFSPPRDASFLDSLIGLSEPVTDVLAPLLES
                     QFEDTAVVPLDPVPV"
     misc_feature    392..1066
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     misc_feature    392..1066
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     exon            360..619
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..934
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2926
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgggc aggctgcacc gacggccgcc tggccgagcg cactgcaggt cgctgcgcgc
       61 gctgcgaccc cggggcccgg acgcgagtgg ctgcggtgtc ctgggcgagc actgctagtt
      121 taggccgtct gtcctcagct gcttggaacc cctacatccc accatggctg ggatacagaa
      181 gaggaagttt gaccagctgg aagaggacga ctgcagctcc tcctccttgt cctctggcga
      241 tctctctccc tctcctccca gctcttctgc ctcccctgcc tggacctctg aggaggaggg
      301 actgggtgat cagccacccc agcctgatca ggactccagt ggcatccaga gtttaatgcc
      361 cccatccatc ctgaagcggg ctcctcggga gcgtccgggt cacgtggcct tcgatggcat
      421 cactgtctac tatttcccgc ggtgccaggg attcaccagt gtgcccagcc atggtggctg
      481 taccctgggc atggcttctc gtcatagcac ctgccgcctc ttctccttag ccgagtttaa
      541 acaggagcag ttccgggctc ggcgtgagaa gctccgtcgg cgtttaaagg aggagaagct
      601 agagatgctg aaatggaagc tttcagtgtc cggagttccg gaggcagggg cagacgtgcc
      661 gctcacagtg gacgccatcg atgacgcttc tgtagaggag gacttggcag tggccgtggc
      721 aggtggccgc ctggaggaag cgaatttcct acagccctat ccacctcggc agcgacgggc
      781 cctacttcgc gcttccggtg ttcgaaggat tgaccgagag gagaagcgcg agctgcaggc
      841 gctacgccaa tcccgggagg attgtggttg tcactgtgat ggcgtctgtg accctgagac
      901 ctgcagttgc atcctggccg gcattaaatg ccagatggat cacacgtcct tcccctgtgg
      961 ctgctgcagc gagggctgtg agaaccccca tggtcgagtg gaattcaatc aggcgagagt
     1021 tcagacacac ttcatccaca cgctcacccg cctgcagatg gagcagggtg cggagagttt
     1081 gggggacccg gagtccccca tggaggacgt tcctgtcgaa caaaccgtgg tttccccctt
     1141 tcctccttcc aaacccacta tgagcaatga cctgggggac agcagctgtg gcagcgacat
     1201 gacagactct tccacgacct actcctctgg cggcagtggc agccgcagcg aggctccgaa
     1261 ccatcttgcc caccccagcc tgccaggttc cagcttccgg tctggcatag atgaagacag
     1321 cctggaacag atcctgaatt tcagtgactc tgacctcggt attgaggaag aagaggagga
     1381 gggagggagt gtgggcaact tggataacct cagctgtttt catttggctg acatctttgg
     1441 taccggtgac cccggcagcc tggctagctg gacacacagc cagtttggct ctagccttcc
     1501 atcgggcatc ctagatgaga atgccaacct ggacgccagc tgcttcctaa gcagcggact
     1561 cgaagggttg agagaaggta gcctccccag cagttctggg tcccctgagg gggaagccgc
     1621 ccagagcagc tccttggacc tcagtttatc ctcctgtgac tcctttgagc ttctccaatc
     1681 tctgccagat tatagtctgg ggcctcacta tacttcccga agggtatctg gcagcctgga
     1741 cagccttgag accttccacc cttcgcccag cttctctcca ccgagggatg ccagcttcct
     1801 ggattctctc ataggcctgt ctgagccggt tacagatgtc ctggcgcccc ttctggagag
     1861 ccagtttgag gacactgctg tggtgccttt ggaccctgtg cctgtgtaag gattgagatg
     1921 actttttcct gccctgagac cctgttgctg ctttttatgt gatcttggtg tcccccaagg
     1981 tctgtgtatg taacggtctc ccgtgggctg gttctgcccc cgtgccatgt gggcaatcct
     2041 ctatttttac agtaacactc tagatttatt tattttttta tgtttttctg tactgaaggg
     2101 agggtgggaa gggtatccct ctttcaatgc ctggcctcta tgtccaaaca gaggtctccc
     2161 acctcctact gtatgcctgg aggaggaagg ggcagggttc acatcccctc tttctgtact
     2221 gtaaaatgct ccttggtcca aagacagctg aaaagcaggc cttagggttt cctgtggacc
     2281 gtgggagcta ggtcttctgg actgtgaaga tgtaatttat ttctgtaatt tatttgggga
     2341 ctgagacagc agtggttggg cctctctggc aggtgggcgg tgttgaggca aagtcttcgg
     2401 tgtcccccgc cggtctgggc ttcggtgtgg cgtgtaggtt cgagctgagc agacggaggc
     2461 tgtgcttgac catcggtgat caaaactccc tctgccccct gcccagacgc tctaacatgc
     2521 cctctgtcca tttccctctc cccaaggcca tgggttataa aggccctatg taggatgggg
     2581 agccagaggc cctaagacat gaagcacacc ccagatcact gtctctagcc tttctgggca
     2641 ctgaatccat cctgacccac cacacacccc ccggccagtt ggcaagaaag aggtggctct
     2701 tgggggcttt tatgcccttc attagctgat gttggatttt atatgcattt ttatattgtc
     2761 tctaagtgtc agaactataa tttattcatt tctctgtgtg tgtgtgtgcc aagaaacgca
     2821 ggctctgggc ctgcctcctt gcccaggagg ccttgccagc ctgtgtgctt gtgagaacac
     2881 attgtacctg agctgacagg taccaataaa gacactctat ttttaa
//
LOCUS       NM_001436555            3357 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 4, mRNA.
ACCESSION   NM_001436555 XM_008766328
VERSION     NM_001436555.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 3357)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_008766328.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1633603.1,
                                           SRR26643290.29285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000008.1  60280533-60280738   c
            207-504             JAXUCZ010000008.1  60277553-60277850   c
            505-662             JAXUCZ010000008.1  60271374-60271531   c
            663-734             JAXUCZ010000008.1  60266449-60266520   c
            735-834             JAXUCZ010000008.1  60265595-60265694   c
            835-3357            JAXUCZ010000008.1  60261325-60263847   c
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3357
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..206
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1195
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="layilin isoform 4 precursor"
                     /protein_id="NP_001423484.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGQRFCWEGTRRPCYRV
                     IYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGDFWIGLKR
                     LEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPPGIGGPYM
                     FQWNDDRCNTKKNFICKYSDGEATEPAAPILPEETLEIDTKERREAALNLAYILIPSI
                     PLFLLLVVTSAVCWVWICRRKREQTDPPTKEQHTIWPTPHQENSPDLEVYNVIRKQSE
                     ADLAEPRPDLKNISFRVCSGEAMPDDTSCDYDNMVINPSESGLVTLASMEGRFVTNDI
                     YEFSPDRMGRSKESGWVENEIYY"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153057"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153057"
     exon            207..504
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            505..662
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            663..734
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            735..834
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            835..3357
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcgggca gcggttctgc tgggaaggga cacggaggcc
      241 ttgctacaga gtcatttatt tccatgacac ctctcaaaga cggaactttg aggaagcgaa
      301 agaagcctgc atgaaggatg gaggacagct agccagcata gaaacggcag atgagcagag
      361 gctgatagag aacttcattg aaagcctcca ggcatctgat ggtgatttct ggattggcct
      421 caagaggttg gaggagaaac agcacaacag cacagcctgc caggaccttt acgcttggac
      481 agatggaagc ctgtcacagt tcaggaactg gtatatggat gagccttcct gtgagagcga
      541 ggtctgcgtg gtcatgtacc atcagccatc agcacctccg ggcatcgggg gcccatatat
      601 gttccagtgg aatgacgacc ggtgcaacac gaagaagaat ttcatttgca aatattctga
      661 cggtgaagca actgagccag cagcacccat acttccagaa gaaactctgg aaatagacac
      721 caaagaacgc agagaggctg ctttgaatct tgcctacatc ctaattccca gtattcccct
      781 tttcctccta cttgtggtca cttcagctgt gtgttgggtt tggatctgta gaagaaaacg
      841 ggaacagaca gaccctccca caaaggagca gcacaccatt tggcccactc ctcaccaaga
      901 gaacagccct gacctagaag tttacaatgt catcagaaaa caaagtgaag ctgatttagc
      961 cgagccccgg ccagatctga agaacatctc cttccgggtg tgttctgggg aagccatgcc
     1021 cgatgacacg tcttgtgact atgacaacat ggttataaac ccttctgaaa gtgggttagt
     1081 gactttggca agtatggagg gtagatttgt gaccaatgac atctatgaat tctcccccga
     1141 cagaatgggg aggagcaagg agagtggatg ggtagaaaat gaaatatatt actaagacat
     1201 atgaaaaaac cagcaagaat gtaaaaagag aaggaaaagc ctccaatgtc ttacaaagac
     1261 gatattcaga aggcttatga gaaggttcag ctcaggtctt aggggcaagc acagcatcac
     1321 aagttccttc tgggtcccca agttctggct gcactcccta tccaggaacc tcgtccagct
     1381 cagcctggtc caaggcacct cacccaaggg gctgctgcac agcagaccct cagagaaagc
     1441 cagtggcttc caactgacgc tcaagagctg gtgctttccc tggtcaggat taaggtgtga
     1501 ccagggagct tggaaagcct acctctaggc tctgttttcc ttgctctgta catctgtgca
     1561 ggcaatcaca aagacacaaa tggtgggatc ctctcaaagc ctctgtatgg aagccccagg
     1621 ctggcctgca catcaacaat tcccaacctg catcccaccc ccacccctga aaaaaaaagt
     1681 caataaaaag caggaagcag aatgttagtc agtctgtgtc tacagccctt cctctgcatg
     1741 tggcctcagg ggagtttttt tttttttttt cattctccca acatctaaac ttggaaaagt
     1801 ccaacttgga aatactttcg aaagtaaaaa tgagctctgt ttgcttcaga gcttcttctt
     1861 ctctgggctc agacagtatg tgctgttctg gggatgggtg gcagcagcat aggaaactga
     1921 ctgtatacag gactggtgaa aagagtcgac ctagtaagga aaaggagagg caggcttctc
     1981 actatcagag aaggcagcca cggtcaccag aagggaggaa actggaacag gtcctgttgt
     2041 gtgcaagggg aatcgaaaca gtgctgccgt cattgtggaa ttttatgtac tgagtataca
     2101 tatatatgta tgtttatatg tgtatgtata tgtgtgtttt ccattaaata agccagtact
     2161 ccatgaaact ggatgactca aggacagaag cagaagaaat atgagttact taagtaatga
     2221 aaaggaaata atgggtatct aaacatagat agaattaaca ggtttattgt tctacaggaa
     2281 caatgaggac ccggatatca caatgaccta taacgtattt atgaataact atgagaaagg
     2341 agctcaaggg cagcaaacac aaagtcatga taaaaatata tttattgcct tggttgacta
     2401 gtacacattg tatatttgta ctgttaagta ataccattgt taaaacttaa agagattggg
     2461 aatgagaatg ttcatttggg aaattttaca ccaccaccaa gcaagactga ttaagaatca
     2521 gcagataggg ttggggattt agctcagtgg tagagtgctt gcctagcagg cgcaaggccc
     2581 tgggtttggt ccccagctcc ggaaaaaaaa aaaaaagaga gagagagaga gaaaaaaaaa
     2641 agaatcagca gatcacagac accaactcgt aatgatccac ctttggtaat gaggattaat
     2701 ttgaatatta aatcattgaa agtaaaacca acaaagagaa tgtgactcaa tgggtaaagt
     2761 gggaaaacat gggcatatgc tgatacaaaa taaaagaata aattaaaact ttgatgtaga
     2821 tggtatattt acatgatttc aggtaaagat cattgattgc aaaagtgacc caacaggcaa
     2881 agccacctca gtcacctgat gaatgtgaat tctgtggacg acgaagtgta ctgagattgt
     2941 agacctcaca ctgtggtgtg gtgagaggga catggcatca catccacgct gtctcacagt
     3001 gtacaagctg atcataagga ggccttgcat aacaacaatt tgatggacaa tctacaaact
     3061 acctggacgg caaacctgaa ctctgatggt aaagacggtg gaagcgagac aggggcagct
     3121 gcaataggag gacagtaagg tgatggctcc aagcgtgacc agatcctgaa atggatccct
     3181 tttctcctgt aaaggagaag atgggaacaa atgtggatga cgtctgagga ctaaatgtca
     3241 aaaacgtgca gtgctaactt cctaactttt gcgttgccct gaggacatgg cctcttggca
     3301 ctgggaatgt cttcccagaa agcacacagt gaagtaataa aggacaatgg actatca
//
LOCUS       NM_001436532            1947 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), transcript variant 4, mRNA.
ACCESSION   NM_001436532 XM_063265794
VERSION     NM_001436532.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_063265794.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1641764.1,
                                           SRR26360176.665737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984027, SAMN16418971
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000008.1  96988079-96988151
            74-207              JAXUCZ010000008.1  97007968-97008101
            208-307             JAXUCZ010000008.1  97016484-97016583
            308-1947            JAXUCZ010000008.1  97022942-97024581
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1947
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..73
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    63..65
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="upstream in-frame stop codon"
     exon            74..207
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..698
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001423461.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     misc_feature    120..377
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     misc_feature    120..377
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     exon            208..307
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            308..1947
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccactgg cggtggcggc acagcagcgg tgaggctcgc gcaccggagg agctggaccg
       61 tgtaaagcct gcggatggag atgtctgccc agaggctgac ttctaacaga acatccccac
      121 agtcaccatc taactctgac tatacctggg aatacgagta ctatgagatc ggaccggttt
      181 ccttcgaagg actgaaggct cacaaatatt ccatcgtgat tggattctgg gttggtcttg
      241 cggtctttgt gattttcatg ttttttgtgc tgactttgct gacaaagaca ggcgccccac
      301 accaagacaa tgcggagtcc tcagagaaga ggttccgaat gaacagcttt gtgtcagact
      361 ttgggaagcc cctggagtca gacaaggtgt tttctcgtca gggcaatgag gagtccaggt
      421 ctctgttcca ctgttacatc aatgaagtgg aacacttgga cagggttaaa gtttgccacc
      481 gaacaacagc cattgacagc gatgtccatc tccaggaagc catcagaagc agtgggaggc
      541 ctgaggagga gctaaccagg tttatgcagt ttgacatccc caacttcgtg aacacagacc
      601 agaactcctt tggggaggat gatcttctta tttcggaacc acctgttctt ctagaaaata
      661 agccagtttc ccagacatca cgtacagacc tggactgaga cacacttgtg ggtgccttcc
      721 tgaggatgtg ttctgtttct gtgcagcaag aaaccacatg ctacctacac ttgtgtgtgt
      781 gtgtgtggag agagagagag agagagagag agggagggag agagagagag agagagaggg
      841 ggagggagga ggcggcagcg ggtggggaag aggatgatgt ttaaagttta agacctaggc
      901 taggactggg atttagtgat agaggggcag aatttgaaga tgggaggcac cattttgatt
      961 tggggagggt gatttttttc tctttggatt aaaaatgcct tgacagtatt aaagcttctt
     1021 tattgaaacg attagccaac acatgcaatt gagctccctc ctgggtgagg gctagttcgc
     1081 tgcagtcggg tctagccctt tcccaccatc ctctgcctgt aacaagctgc tttgcctctc
     1141 tggactgcca tggctttaca ggtaaggtgg cctgtccgga gtagatgacc tatcccagct
     1201 ctagaatttt gtgactttca aacttagcta taagataagc taagaaacgc ataagcagta
     1261 gaaaatacca cacggcatcg aggctttcat ggcaggttct tcaggtctcg gtgctctccc
     1321 ttcactcagt ccttcactgg gtcacacttt cggtagggaa atctttacta ggagaccagg
     1381 agacatgaga cttgcacgca ctgtggacag tgtctctgct gggtgttgct acagcaattt
     1441 atgtgctgaa cgcccccccc ccccgcttta aactgggata gcttcgactc cagcgactac
     1501 cagcccaaac tgttttcaca agcatctgtg ctcttgaaga atggtagagc agattgttat
     1561 ttggctgatg tgagtccctt ctggatgtcc ctgtgtttgc atccctgggc tcacccttct
     1621 gaactatttg gcttcagaac aggaagatac cgctcgccat gtctgcgtgg cagatgtgta
     1681 ggtgacggct gcctggcttg gagctgagag ggtccgtggg ttttttgcca cagtaacaga
     1741 tgttcaggat tggaggatgt taatatgagc cacatgatgt ccgtctcaca aagcaagcag
     1801 ccccctttgc tggagtcaga aacaacccag tcctgcacac acagagttgt acgcatgagc
     1861 agctgctaat ctctgggtgg catcttcttt atgaatttgt tcaccatttg tcttgcttaa
     1921 gttgcaaaat aaatgcattt gatcgca
//
LOCUS       NM_001436556            1625 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 5, mRNA.
ACCESSION   NM_001436556 XM_039081959
VERSION     NM_001436556.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039081959.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.3439546.1,
                                           SRR21887623.3439547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000008.1  60280533-60280738   c
            207-504             JAXUCZ010000008.1  60277553-60277850   c
            505-662             JAXUCZ010000008.1  60271374-60271531   c
            663-698             JAXUCZ010000008.1  60267495-60267530   c
            699-770             JAXUCZ010000008.1  60266449-60266520   c
            771-870             JAXUCZ010000008.1  60265595-60265694   c
            871-1110            JAXUCZ010000008.1  60263608-60263847   c
            1111-1625           JAXUCZ010000008.1  60261325-60261839   c
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1625
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..206
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1114
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="layilin isoform 5 precursor"
                     /protein_id="NP_001423485.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGQRFCWEGTRRPCYRV
                     IYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGDFWIGLKR
                     LEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPPGIGGPYM
                     FQWNDDRCNTKKNFICKYSDDKPSTTPSLSPGGEATEPAAPILPEETLEIDTKERREA
                     ALNLAYILIPSIPLFLLLVVTSAVCWVWICRRKREQTDPPTKEQHTIWPTPHQENSPD
                     LEVYNVIRKQSEADLAEPRPDLKNISFRVCSGEAMPDDTSCDYDNMVINPSESG"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     exon            207..504
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            505..662
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            663..698
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            699..770
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            771..870
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1110
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1625
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcgggca gcggttctgc tgggaaggga cacggaggcc
      241 ttgctacaga gtcatttatt tccatgacac ctctcaaaga cggaactttg aggaagcgaa
      301 agaagcctgc atgaaggatg gaggacagct agccagcata gaaacggcag atgagcagag
      361 gctgatagag aacttcattg aaagcctcca ggcatctgat ggtgatttct ggattggcct
      421 caagaggttg gaggagaaac agcacaacag cacagcctgc caggaccttt acgcttggac
      481 agatggaagc ctgtcacagt tcaggaactg gtatatggat gagccttcct gtgagagcga
      541 ggtctgcgtg gtcatgtacc atcagccatc agcacctccg ggcatcgggg gcccatatat
      601 gttccagtgg aatgacgacc ggtgcaacac gaagaagaat ttcatttgca aatattctga
      661 cgataaacca agtacaacac cctctcttag tcctggaggt gaagcaactg agccagcagc
      721 acccatactt ccagaagaaa ctctggaaat agacaccaaa gaacgcagag aggctgcttt
      781 gaatcttgcc tacatcctaa ttcccagtat tccccttttc ctcctacttg tggtcacttc
      841 agctgtgtgt tgggtttgga tctgtagaag aaaacgggaa cagacagacc ctcccacaaa
      901 ggagcagcac accatttggc ccactcctca ccaagagaac agccctgacc tagaagttta
      961 caatgtcatc agaaaacaaa gtgaagctga tttagccgag ccccggccag atctgaagaa
     1021 catctccttc cgggtgtgtt ctggggaagc catgcccgat gacacgtctt gtgactatga
     1081 caacatggtt ataaaccctt ctgaaagtgg gtaaagatca ttgattgcaa aagtgaccca
     1141 acaggcaaag ccacctcagt cacctgatga atgtgaattc tgtggacgac gaagtgtact
     1201 gagattgtag acctcacact gtggtgtggt gagagggaca tggcatcaca tccacgctgt
     1261 ctcacagtgt acaagctgat cataaggagg ccttgcataa caacaatttg atggacaatc
     1321 tacaaactac ctggacggca aacctgaact ctgatggtaa agacggtgga agcgagacag
     1381 gggcagctgc aataggagga cagtaaggtg atggctccaa gcgtgaccag atcctgaaat
     1441 ggatcccttt tctcctgtaa aggagaagat gggaacaaat gtggatgacg tctgaggact
     1501 aaatgtcaaa aacgtgcagt gctaacttcc taacttttgc gttgccctga ggacatggcc
     1561 tcttggcact gggaatgtct tcccagaaag cacacagtga agtaataaag gacaatggac
     1621 tatca
//
LOCUS       NM_001033072            1348 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus triosephosphate isomerase 1 like 1 (Tpi1l1),
            transcript variant 3, mRNA.
ACCESSION   NM_001033072 XM_576370
VERSION     NM_001033072.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001033072.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22399489.2845270.1, AY461585.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              JAXUCZ010000008.1  31923596-31924943   c
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1348
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase 1 like 1"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
     exon            1..1348
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..777
                     /gene="Tpi1l1"
                     /EC_number="5.3.1.1"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="triosephosphate isomerase 1 like 1 isoform 2"
                     /protein_id="NP_001028244.2"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
                     /translation="MAPSRKFFVGGNWKMNGKKKCLGELICTLNAAKMPADTEVVCAP
                     PTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHV
                     FGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSK
                     VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEEVAQCTRIIYGGSVTGATC
                     KELASQPDVDGFLVGGASLKPEFVDIINAKQ"
     misc_feature    31..768
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    31..768
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    order(61..63,67..69,313..315,523..525,541..543,661..663,
                     718..720,724..729)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(61..63,67..69,313..315,523..525,541..543,661..663,
                     718..720,724..729)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(61..63,70..72,163..171,175..177,184..186,220..222,
                     274..276,283..288,319..324)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(61..63,70..72,163..171,175..177,184..186,220..222,
                     274..276,283..288,319..324)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(67..69,313..315,523..525)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
     misc_feature    order(67..69,313..315,523..525)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
ORIGIN      
        1 gaccttcaga gagttgatcc ttgtgcaatg gcgccttcca ggaagttctt cgtcgggggc
       61 aactggaaga tgaacgggaa gaagaaatgc ctgggagaac tcatctgcac cctgaacgca
      121 gccaagatgc cggcagacac cgaggtggtt tgtgcaccgc caaccgccta catcgacttc
      181 gccaggcaga agctggatcc caaaattgct gtggctgcac agaactgcta caaagtgacc
      241 aatggggctt tcactgggga aatcagccct ggcatgatca aagacttagg agctacctgg
      301 gtggtgctgg gacactcgga aagaagacac gtctttgggg aatcagacga gttgattggg
      361 cagaaagtga accatgccct atccgaggga ctcggagtga tcgcctgcat tggggagaag
      421 ttagacgaaa gggaagctgg catcactgag aaggttgttt ttgagcaaac caaggccatc
      481 gcagataatg tgaaggactg gtccaaggtg gtcctggcct atgaaccggt atgggccatt
      541 gggactggca agactgcaac ccctcaacag gcccaggaag tacacgagaa gctccgggga
      601 tggctgaagt gcaacgtctc tgaggaggtg gctcagtgca ctcggatcat ttatggaggt
      661 tctgtgactg gagcgacttg caaagagctg gcaagccagc ctgatgtgga tggcttcctc
      721 gtgggcggtg catctctcaa gcctgaattc gtggacatta tcaatgccaa acaatgagca
      781 ctgctcatcc ccctaccttc ctgcgtagcc tggaccaggt tgcccagaag tttagtaact
      841 gctcccgcca gtcacatgct tctgatgaca tcatcaactc catcctgtga cctattccat
      901 actgtacctt cctgagcctc ttacctcccc ataatagttg ggaccaggcc aatcccttta
      961 ccacttacaa tgggtaaaat caaatatgtc accaagatgg cttcctgagg aggggaagga
     1021 gtagaactgg cagtcccttt gggccctaat gggtgaaaac ggccttccat tggtttggga
     1081 tggaaactca tggctggacc acaggaagta ggcttcttgt cactttggcc tgtcacttag
     1141 atggccttgg ctctagcttc actcccaagc cctactggat gtgtgatgca gagattcaga
     1201 gtcttcaggt ctgaatttca gtgtacatta aggccaagat cctcttactc ttagaggcct
     1261 gggatatccc ctcccccgca gtgccaaagc ccttgtattg tgtttgtgaa ccatcctacg
     1321 tataagggaa ataaacacct gggcctaa
//
LOCUS       NM_001436560            2208 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus galactosidase, beta 1-like 2 (Glb1l2), transcript
            variant 4, mRNA.
ACCESSION   NM_001436560 XM_039082000
VERSION     NM_001436560.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039082000.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.27718.1,
                                           SRR22582416.1079335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000008.1  33442384-33442511   c
            129-326             JAXUCZ010000008.1  33432033-33432230   c
            327-395             JAXUCZ010000008.1  33430296-33430364   c
            396-491             JAXUCZ010000008.1  33429601-33429696   c
            492-600             JAXUCZ010000008.1  33427276-33427384   c
            601-693             JAXUCZ010000008.1  33415421-33415513   c
            694-775             JAXUCZ010000008.1  33412669-33412750   c
            776-846             JAXUCZ010000008.1  33402492-33402562   c
            847-931             JAXUCZ010000008.1  33400046-33400130   c
            932-1069            JAXUCZ010000008.1  33398755-33398892   c
            1070-1150           JAXUCZ010000008.1  33398103-33398183   c
            1151-1257           JAXUCZ010000008.1  33397502-33397608   c
            1258-1398           JAXUCZ010000008.1  33396800-33396940   c
            1399-1470           JAXUCZ010000008.1  33396496-33396567   c
            1471-1549           JAXUCZ010000008.1  33396178-33396256   c
            1550-1637           JAXUCZ010000008.1  33395117-33395204   c
            1638-1749           JAXUCZ010000008.1  33394725-33394836   c
            1750-1866           JAXUCZ010000008.1  33394238-33394354   c
            1867-2208           JAXUCZ010000008.1  33391216-33391557   c
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2208
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="galactosidase, beta 1-like 2"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
     exon            1..128
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2130
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /EC_number="3.2.1.23"
                     /note="isoform 4 is encoded by transcript variant 4;
                     beta-galactosidase-1-like protein 2"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein 2 isoform 4"
                     /protein_id="NP_001423489.1"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
                     /translation="MPKWSLRRRPGRTLGLLLLLVLSFLVLRRLNWTSVLPLWLQRQR
                     LGLRTKGPNFMLEDSTFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLH
                     EPERGKFDFSGNLDLEAFIWLAAKIGLWVILRPGPYICSEIDLGGLPSWLLQDPDMKL
                     RTTYPGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNGDHAYMPYIKKA
                     LEDRGIIEMLLTSDNKDGLEKGVVDGVLATINLQSQQELVALNSILLSIQGIQPKMVM
                     EYWTGWFDSWGGSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFGD
                     YKADVTSYDYDAILTEAGDYTAKYTKLRELFGTFSGVPPPPPPELTAKMVYEPVTPSF
                     YLSLWDALLYMDKPITSEIPINMENLPVNNGNGQAFGYVLYETTIFSSGVLSGLVRDR
                     GQVFLNRVSIGFLDYTTTKITIPLTQGYTILRILVENRGRVNYGNNIDSQRKGLIGNL
                     YLNNKPLKNFKIYSLDMTKQFFQRFDMDKWSVVPKEITFPAFFLGTLSVGIYPSDTFL
                     KLEGWVKGVVLVNDHNLGRYWNVGPQETLYLPGVWLDKGLNKHVQPTLALQHRLVLPG
                     PVNHIRDLSPSRVLAPTPNCSETLLAPPSHFCLLTVWDHTCGILTPAPSSVCPQPHGR
                     NTDSWPSLSVACM"
     misc_feature    199..1140
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     misc_feature    199..1140
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     exon            129..326
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            327..395
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            396..491
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            492..600
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            601..693
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            694..775
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            776..846
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            847..931
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1069
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1150
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1257
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1398
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1470
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1549
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1637
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1749
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1866
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2208
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggagtag gaaccccggt gtctaccagc ggctttcgcg cgatgcccaa gtggagcctg
       61 cggcggaggc cgggccgcac actcggactc ctgctgctgc tggtcttgag cttcctggtg
      121 ctccgcaggt tgaactggac ctctgtgctt cccctatggc tccaacgtca gcgcctggga
      181 cttcgaacaa aaggcccaaa cttcatgctg gaggactcca cctttcagat tttgggggga
      241 tccatacact atttccgtgt gcccagggaa tactggaggg accgcctgct caaactgaaa
      301 gcctgtggct tgaataccct tactacctat gtgccatgga acctccatga gccagaacga
      361 ggcaaattcg acttctctgg gaatctggac ctagaggcct ttatctggct ggctgcaaag
      421 attggcctgt gggtgattct gcgaccaggg ccctacatct gtagtgagat tgacctcggg
      481 ggcttgccca gctggctcct tcaagaccct gacatgaagc taagaacaac ttaccctggc
      541 ttcactaagg cagtggatct ttactttgac cacctgatgt ccagggtggt gccgcttcag
      601 tataagcatg gggggcctat cattgcggtg caagtggaga atgagtacgg ttcctataac
      661 ggagaccatg cgtacatgcc ttacatcaag aaggcactgg aagaccgtgg catcattgag
      721 atgctcctga cctcagacaa caaagatggc ctggaaaagg gagtggttga cggagtgctg
      781 gccaccatca acttacagtc acaacaggag ctggtggcac taaacagtat tctcttatct
      841 atacagggga ttcaacccaa gatggtgatg gagtactgga cagggtggtt tgactcgtgg
      901 ggtggctccc acaacatctt ggattcctct gaggtcctgc aaacagtgtc tgccatcatc
      961 aaagacggct cctccatcaa cctgtacatg ttccatggag gcacaaattt tggcttcata
     1021 aatggagcca tgcattttgg tgactacaag gctgatgtta ccagctatga ctacgatgct
     1081 atattgacag aggctggaga ttacactgcc aaatacacca agcttcgaga actctttgga
     1141 accttctcag gcgtccctcc acctcctcca cctgagctta ctgctaagat ggtctatgag
     1201 ccagtgactc catctttcta cctgtcactg tgggacgctc tcctgtacat ggataagcca
     1261 atcacatctg agatacccat caacatggag aacctgccgg taaacaatgg taatgggcag
     1321 gcctttgggt atgtcctcta tgagaccacc atcttttcat ctggcgtcct cagtggcctt
     1381 gtgcgtgaca gaggacaggt ctttttgaac agagtgtcca taggattctt ggactatacg
     1441 acaacgaaga tcactatccc cttgacccag ggttacacaa tactgaggat cttggtggag
     1501 aatcgtgggc gagtcaacta cggaaataac attgacagcc agcgcaaagg tttaattgga
     1561 aatctctatc tgaataataa acccctgaaa aacttcaaaa tctacagcct ggatatgaca
     1621 aagcagttct ttcagaggtt cgacatggac aagtggagtg tcgtacccaa agaaattacc
     1681 tttcccgctt tcttcctggg caccttgtca gttggcattt acccttctga cacatttctg
     1741 aagttggagg gctgggtgaa gggggttgtg ctcgtcaatg atcacaacct tggacgctac
     1801 tggaatgtag gacctcagga gactctctac ctccccggtg tctggctgga caaaggactc
     1861 aacaagcatg tgcagccgac cttagctctc cagcatcgac tagttcttcc cggtcctgtg
     1921 aaccacatac gtgatctcag cccctccaga gttcttgcac caacacccaa ttgctctgag
     1981 actctgctcg ctcctccttc tcatttttgt ctcctcactg tgtgggacca cacctgtggg
     2041 atcttgacac cagcaccctc cagtgtctgt ccccagcctc acggcaggaa cacagacagc
     2101 tggccctcac tatctgttgc atgtatgtga cgaggtcaga agtagaactt cgctttccct
     2161 catgtgacct ctactgcact ctgtcgagta aaaacaagtg gaaattcc
//
LOCUS       NM_001436562            2491 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 25 (Tmem25), transcript
            variant 2, mRNA.
ACCESSION   NM_001436562 XM_006242960
VERSION     NM_001436562.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Zhang,H., Tian,X., Lu,X., Xu,D., Guo,Y., Dong,Z., Li,Y., Ma,Y.,
            Chen,C., Yang,Y., Yang,M., Yang,Y., Liu,F., Zhou,R., He,M., Xiao,F.
            and Wang,X.
  TITLE     TMEM25 modulates neuronal excitability and NMDA receptor subunit
            NR2B degradation
  JOURNAL   J Clin Invest 129 (9), 3864-3876 (2019)
   PUBMED   31424425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006242960.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.34799.1,
                                           SRR26643289.22724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000008.1  54009314-54009377   c
            65-158              JAXUCZ010000008.1  54008719-54008812   c
            159-470             JAXUCZ010000008.1  54008159-54008470   c
            471-761             JAXUCZ010000008.1  54006503-54006793   c
            762-893             JAXUCZ010000008.1  54006205-54006336   c
            894-924             JAXUCZ010000008.1  54005871-54005901   c
            925-1025            JAXUCZ010000008.1  54005600-54005700   c
            1026-1112           JAXUCZ010000008.1  54005420-54005506   c
            1113-2491           JAXUCZ010000008.1  54003907-54005285   c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2491
                     /gene="Tmem25"
                     /note="transmembrane protein 25"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
     exon            1..64
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            65..158
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1186
                     /gene="Tmem25"
                     /codon_start=1
                     /product="transmembrane protein 25 precursor"
                     /protein_id="NP_001423491.1"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
                     /translation="MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRE
                     NEHHAFTCRVAGGSATPRLAWYLDGQLQKATTSRLLSVGGDAFSGGTSTFTVTAQRSQ
                     HELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPP
                     ANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTS
                     ASLPAPGLLATRIEVPLLGIVVAGGLAFGTLVGFSTLVACLVCRKEKKTKGPSRRPSL
                     ISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDIRGKATERPMAQHSSRPELLEAEP
                     GGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL"
     sig_peptide     89..166
                     /gene="Tmem25"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    167..442
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    167..442
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    230..244
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    230..244
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    272..286
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    272..286
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    359..370
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    359..370
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    398..415
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    398..415
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     exon            159..470
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            471..761
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            762..893
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            894..924
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1025
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1112
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..2491
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgtact gcggcgctca gcgacttgag caattgctgg ggctctgctc caggagggag
       61 ccagcctgga ggccagtccc tgatcaccat ggagttgcct ctaagccaag ctacgctccg
      121 gcatactctg ctgctcctgc ctgccctctt aagttcaggt caaggagagc tggcgccaca
      181 aattgatggt cagacctggg ctgagagagc acttagggaa aatgagcacc atgctttcac
      241 ctgtcgggtt gcagggggtt ctgccactcc ccgattagcc tggtacctgg atggacagct
      301 acagaaggct accacctcgc gactcctgag tgtgggcggg gacgccttct ctggaggtac
      361 cagcactttc actgtcactg cccagcgctc ccaacatgag cttaactgct ccctgcagga
      421 cccagggagt ggccggccag ccaatgcctc tgtcattctc aatgtgcaat tcaaaccaga
      481 gattgcccag gttggagcca agtaccagga agctcagggc ccaggccttc tggttgtcct
      541 gtttgccctg gtacgggcca acccacctgc caatgtcacc tggattgacc aggatgggcc
      601 agtgactgtc aatgcctctg acttcctggt gctggatgcc cagaactatc cctggctcac
      661 caaccacact gtgcagctgc agctccgaag cctggcacac aacctctcgg tggtggccac
      721 caacgatgtg ggtgtcacca gtgcctcact tccagctcca gggctcctgg ccacacggat
      781 agaagtgcca ctgctgggca tcgttgtggc tggaggactt gcctttggca ctctagtggg
      841 attcagtacc ttggtggcct gcctggtctg caggaaagag aagaaaacaa aaggcccctc
      901 ccggcgtcct tctctgatat ctagtgactc caataacctg aaactgaata atgtgcgcct
      961 gccccgggag aacatgtccc tcccatccaa ccttcagctc aatgacctca ctccggatat
     1021 cagagggaaa gcaacagagc ggccaatggc tcagcatagc agccgtccag agcttctaga
     1081 agcggagcct ggtggcctcc tcaccagccg aggtttcatc cgtctcccaa tgttgggcta
     1141 catctaccgt gtgtccagcg taagcagtga tgagatttgg ctctgagctt gagagtgagg
     1201 cagatggccc aggtggtctg tggactcccc agagtgacca ccccttcttg aagcatcttc
     1261 ttcaagcttc cctctgcctg gccctgttgt gaccatgaag aaaccatgtc actgccgtct
     1321 ggcctgcctg gcaaggatac ctgtgggtca tgcatgtgta tgtcattgca ctctaacctg
     1381 caagacatgg gtacccttgg caaggccacg ggtcagaact aagccccttg cactcactca
     1441 gtttggggcc ctgcatgtga taacctggtc caggcagacg gaactctggc caggtgtgtt
     1501 tagatgtcac ccgacaccta aaagacgggc ctatttatta tacgtcccac gccagtatcc
     1561 actgcacctt gtgtgcagag agatgcctat gcaggggacc ccgcacaact cagatgacag
     1621 ccttcctttg ctatgcagcc ttgttccctc agggaaaaca tagcccctgc tattgtatag
     1681 aaccaaattg ccctttgctc aggaaccagc ccctcaccca gggacctggc caagcacaaa
     1741 ttcgtccctt ttgctgcaac atatctttct actcttctat ccccacttcc tcttggtcat
     1801 cataggtcat accctagacc ttcttcactg agtattagac ctccattggc tggggcccat
     1861 gggtgcagcc tttggtgtta gcacaagatg agcaagaaga ggtgacagga gggctggctc
     1921 ccaagacagc atgtagcaat gtatcatttt gtacagtgtc ctcatattaa gcacattctc
     1981 caggagcgag gagggcccag ggccttcttg ggttccccat ctttggcctt cagcaattca
     2041 ctgtgagtgt tctgagcact cagggttggt ggtttcctct ctgcatgtct cttcccacca
     2101 tgcagccaca ttcctgacca aacctggctg ccacatccta ttcttccagg gatggtcaca
     2161 gtgggtatag aacccaacag cgccagaagc tttaggggaa cagagggagc aggagcccac
     2221 acagctctaa agagctaaga atacttttaa aaaagcaaca tgaaaatggc aaacaggggt
     2281 tggggattta gctcagtggt agagcgcttg cctagcaagc gcaaggccct gggttcagtc
     2341 cccagctctg gaaaaaaaaa aaaaaaaaaa gaaagaaaat ggcaaacagc agagtatgga
     2401 gtctattttc ctttcttcat atcttgtttg gtaatttttc ttgtgttact ggtgagtact
     2461 gtgctgcaca cacagtaaat tcctttgacc a
//
LOCUS       NM_001436551            2570 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus neurexophilin and PC-esterase domain family,
            member 1 (Nxpe1), transcript variant 2, mRNA.
ACCESSION   NM_001436551 XM_006243019
VERSION     NM_001436551.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006243019.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1210819.1,
                                           SRR26360186.526197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000008.1  57648025-57648082
            59-167              JAXUCZ010000008.1  57657938-57658046
            168-964             JAXUCZ010000008.1  57659095-57659891
            965-1026            JAXUCZ010000008.1  57662970-57663031
            1027-1239           JAXUCZ010000008.1  57668522-57668734
            1240-2570           JAXUCZ010000008.1  57668950-57670280
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2570
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="neurexophilin and PC-esterase domain family, member
                     1"
                     /db_xref="GeneID:500992"
                     /db_xref="RGD:1566243"
     exon            1..58
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            59..167
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1775
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /codon_start=1
                     /product="NXPE family member 1"
                     /protein_id="NP_001423480.1"
                     /db_xref="GeneID:500992"
                     /db_xref="RGD:1566243"
                     /translation="MWIMFSTIMRQKRLLIFTSFLVVIWVIFVISQNSAKLWTTLNTS
                     TSFNPWTTSTKSSPPEIPMNQSTLPTETKLREEIPKMTGHQEDKSPTETELKVREILE
                     KLDGQIPPRPFAHLNNTTSATHSTATILNPQDTYCVGDQLDVLLAAKDYFGHRKEYGG
                     DFLRARMSSPALKAGASGKVTDFNNGTYLISFTLFWEGQVSLSILLMHPSEGVSALWR
                     ARNQGYGRIAFKGTFVNGTSKVTAECGLILNSSSELCKYLYRGGEEVFYCVKPQHMPC
                     EALTYVCTSHQDVSYLTAKEKNLFQKSNIGVEMMKHPKYIVVSQCNKSENGRKRCEIG
                     MEIPTPSGYTLQGRWVSAQCTQRLLTSSQINDCLKGKLIYLLGDSTLRQWIEYLPKVA
                     KTLRPFDLHGTGLYKKHLILDAERHTLVEWKKHSHPFITVQLYSVIDDGYIPQEIDRL
                     PGDKDTVIVITVGQHFRPFPMELFVHRVINIQKAIGRLFLRSPDTKVIIKMENIRERN
                     LDTEKFGDFHGYVQYLTTKEIFKDLHVGTIDAWDMTIAHGTNVLHPPAAVIGNQIDVF
                     LNYIC"
     misc_feature    <522..887
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="Region: Neurexophilin; pfam06312"
                     /db_xref="CDD:428882"
     misc_feature    <522..887
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="Region: Neurexophilin; pfam06312"
                     /db_xref="CDD:428882"
     exon            168..964
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1026
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1239
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2570
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatttgttc tggaaagctt tctaaaggga gttttaagaa aacttcccgc tttaagagga
       61 tgtggatcat gttctccact atcatgcgtc agaagaggct gctaatattc acatcgtttt
      121 tagtggttat ctgggtaata tttgtaatct cccaaaattc tgcaaagcta tggaccactc
      181 taaacacatc cacatccttc aatccctgga ccacatccac gaagtcctca cctcctgaaa
      241 ttccaatgaa ccagtcaacg ttaccaacag agaccaagct aagagaggag atccctaaga
      301 tgacaggcca ccaagaagac aagtcaccaa cagagacaga gctgaaagtc agggagatcc
      361 tggagaagct agatggacag atccctccca gacccttcgc ccacctcaac aacaccacaa
      421 gtgccacaca cagcacagcc accatcctca accctcagga tacatactgt gtaggggacc
      481 agctggatgt cttgctggcg gccaaggact attttggtca caggaaggaa tatggtgggg
      541 atttcctgag ggccaggatg tcctccccag ccttgaaggc aggagcttct ggaaaggtga
      601 cagacttcaa caatggcacc tacctcatca gcttcactct gttctgggag ggccaggtct
      661 ccctgtctat cctgctcatg caccccagtg aaggggtgtc agctctctgg agagcaagga
      721 accaaggcta tggtagaatt gccttcaaag ggacttttgt taatggcaca tccaaggtca
      781 cagctgaatg tggcctgatc ctgaactcaa gcagtgagct ctgcaaatac ctgtaccgtg
      841 gtggcgagga agtcttctac tgcgtgaagc ctcaacacat gccctgtgag gccctgacct
      901 acgtgtgtac cagtcaccaa gatgtttctt atctcactgc caaagaaaaa aacctttttc
      961 agaagtccaa cataggagtt gaaatgatga agcaccctaa gtatatcgtt gtctcccagt
     1021 gcaacaagag tgaaaacggg agaaagagat gtgagatcgg aatggagatt cccacaccta
     1081 gcggttacac tttacaagga aggtgggtat cagcccagtg tactcagcgc ctgttaacct
     1141 caagtcagat aaatgactgc ttaaaaggaa agctcattta cctcctggga gactccacgc
     1201 ttcgccaatg gatcgaatat cttcccaagg ttgcaaaaac gttgagacct tttgaccttc
     1261 acgggactgg gctatataag aaacatttga ttttggatgc tgagaggcac actctggttg
     1321 aatggaagaa acacagtcac cctttcatca ctgtccagct ctactctgtg atagatgatg
     1381 gctatatccc tcaggaaatt gaccgcttgc cgggcgacaa agacactgtc atagtcatta
     1441 ccgtgggcca gcacttcaga ccctttccca tggaactttt tgttcaccga gtcatcaaca
     1501 tccaaaaggc tattggacgg ctcttcctca gaagccctga tactaaagtc atcattaaga
     1561 tggagaatat tagggagagg aacctagata cagagaaatt cggagacttc catggttatg
     1621 ttcagtatct aaccacaaag gagattttca aagaccttca tgtgggtacc attgatgcct
     1681 gggacatgac catcgcacat ggtaccaatg tcctccatcc acctgctgca gtgattggaa
     1741 accagattga cgtgttttta aactacattt gctgaagaag catcactagg agcccagcgc
     1801 tcccagccat accacgtgat ccatcagtga agttttgttc aatgtaggat taaaaaaaac
     1861 aaacaaacaa atttaaaaga atctgtcatg ggatagaggc gagactaagc tgagagggtg
     1921 tctgctcagt atgcacgaag ctggggttca accttcagca ccacataagc agggcacagt
     1981 ggcacgtgct tgtaattcca agactcggga agatcagaag tgaaggtcat ctttgttata
     2041 tagtcaggtc cagtagagcc tgggcttcat gggagcattc cttgattaaa aataatcatc
     2101 atgatcgtga cgggagacat atctaaaaac agtgactaca gagacgaaat ataaagccaa
     2161 aaccaccaag tgcaaaggac catcctagaa cattctctgt ctgtctctgg gatgataaaa
     2221 gcctttattt gttaggcaag catgagcaag cctgatctct gttaatcttg gctaaaccaa
     2281 aagacaggaa gtatccaaga gagcagcatg cctttgccat catgctctaa gactttttta
     2341 ttttaaaaaa gacaaacaaa caaacaaaca aacaaaaaac ccacaccttt tctgcaaaag
     2401 aacagaaagt aagtatccta ggtttggagg accacatatt tacctctgtc accactattc
     2461 cattctgcca ccaaggcaca aaacaagaca aacatgtaag caaataaaaa tgttcttgtt
     2521 tttgttttaa aaaaaaaaac ctagtaataa acaccgaaaa ttgaatttta
//
LOCUS       NM_001025754            1698 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus nei-like DNA glycosylase 1 (Neil1), transcript
            variant 3, mRNA.
ACCESSION   NM_001025754 XM_345944
VERSION     NM_001025754.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Ma,H., Wang,J., Abdel-Rahman,S.Z., Hazra,T.K., Boor,P.J. and
            Khan,M.F.
  TITLE     Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced
            splenic toxicity
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 1-7 (2011)
   PUBMED   21145906
  REMARK    GeneRIF: In the spleen aniline-induced oxidative stress is
            associated with an induction of NEIL1/2.
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Das,A., Boldogh,I., Lee,J.W., Harrigan,J.A., Hegde,M.L.,
            Piotrowski,J., de Souza Pinto,N., Ramos,W., Greenberg,M.M.,
            Hazra,T.K., Mitra,S. and Bohr,V.A.
  TITLE     The human Werner syndrome protein stimulates repair of oxidative
            DNA base damage by the DNA glycosylase NEIL1
  JOURNAL   J Biol Chem 282 (36), 26591-26602 (2007)
   PUBMED   17611195
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced NM_001025754.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099125.1, SRR26643296.21860.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000008.1  66451861-66451920   c
            61-517              JAXUCZ010000008.1  66450320-66450776   c
            518-637             JAXUCZ010000008.1  66448599-66448718   c
            638-701             JAXUCZ010000008.1  66448447-66448510   c
            702-801             JAXUCZ010000008.1  66448117-66448216   c
            802-929             JAXUCZ010000008.1  66447489-66447616   c
            930-957             JAXUCZ010000008.1  66447254-66447281   c
            958-1019            JAXUCZ010000008.1  66447036-66447097   c
            1020-1176           JAXUCZ010000008.1  66446761-66446917   c
            1177-1698           JAXUCZ010000008.1  66446106-66446627   c
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1698
                     /gene="Neil1"
                     /note="nei-like DNA glycosylase 1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
     exon            1..60
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Neil1"
                     /note="upstream in-frame stop codon"
     exon            61..517
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1247
                     /gene="Neil1"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 1; nei endonuclease
                     VIII-like 1"
                     /codon_start=1
                     /product="endonuclease 8-like 1"
                     /protein_id="NP_001020925.1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
                     /translation="MPEGPELHLASHFVNEICKGLVFGGCVEKSSVSRNPEVPFESSA
                     YHISALARGKELRLTLSPLPGSHPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFY
                     TAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRLSPELTLSQKVKA
                     KLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYAVPGMSSLRDRHG
                     RTIWFQGDPGPLAPKGGRSRKKKSQETQLEAEDRKEDPPSKSISRTQRARKHCPKNVP
                     QQSEGASLPQNLETPAVPEKGKRRGRRASTGRHRGPKSKPDTQPREAGEISAS"
     misc_feature    84..464
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    84..464
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    order(87..92,243..245,315..317,321..329,366..371)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    order(87..92,243..245,315..317,321..329,366..371)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    87..89
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    87..89
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(90..101,105..110,117..119,234..248)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(90..101,105..110,117..119,234..248)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(90..92,243..245)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(90..92,243..245)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    <237..>701
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    <237..>701
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    837..953
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     misc_feature    837..953
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     exon            518..637
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..701
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..801
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..929
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..957
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1019
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1176
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1698
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgactgg gattaacccc ttactgatgc tgccccccgg ttgagcagca accggagcag
       61 ggcccagcca ttcctccttc agaatgccgg agggcccaga gctgcacctg gccagccact
      121 ttgtgaatga gatatgtaaa gggctggtat tcggtgggtg tgtggagaag tcctctgtca
      181 gccgaaaccc ggaggtgccc tttgagagca gtgcctacca catctcagct ttagcccgag
      241 gcaaggagct gcgcttgaca ttgagccccc tgcctgggtc ccatccccct cagaaaccac
      301 tgtcccttgt cttccgcttt ggtatgtctg gatccttcca gctggtaccc gcagaagcac
      361 tgccgcgcca cgcccatcta cgtttctata cggccccacc tgccccccgg cttgcccttt
      421 gcttcgtaga catccgccgc tttggccact gggaccctgg aggtgaatgg cagccaggcc
      481 gcggaccctg tgtcttgttg gagtatgaac ggttcagaga gaacgtgctt cggaacctat
      541 cggacaaagc ctttgaccgg cccatctgcg aggccttgtt ggaccagagg ttcttcaatg
      601 gaatcggcaa ctatctgcgg gcagagatct tgtatcggct gaagatcccc ccttttgaga
      661 aggcccgtac agttctagag gccctgcaac agtgccggct gagcccagag ctgaccctga
      721 gccagaaggt caaggccaaa ctgcagaacc cagacctgct ggaactgtgt cacttggtgc
      781 ccaaggaagt ggttcagctg gggggcaaag gctatgggcc agagcgtgga gaggaagatt
      841 ttgctgcctt tcgagcctgg cttcggtgct atgctgtgcc aggcatgagc tccctgagag
      901 accggcatgg ccgtaccatt tggttccagg gtgatcctgg acccttggca cccaaagggg
      961 gcagatcccg aaaaaagaag tcacaggaaa cacagctgga ggctgaggac agaaaagagg
     1021 accctccaag caagtccatt tccaggactc agagggccag gaagcactgt cctaagaatg
     1081 tacctcaaca gtctgaaggg gccagcctcc cacaaaacct ggaaacccct gcagtccctg
     1141 agaaaggaaa gagaaggggg agacgggcga gcacaggccg ccacagagga ccaaagagta
     1201 agcctgatac tcaacccagg gaggctgggg agatttcagc ctcataggta gaggtatcct
     1261 tccctgatga cttgctatca atctagggga atgtctgaat ccctagaacc agtatttgta
     1321 gggctacatg ccctgggccc tgtgattttt ttcctgcaca actgttgtct gaggtggggt
     1381 ctcctgtgtc ctatccttga atccatatgt acctgaagat gacattgaac tcctcctgtt
     1441 tgatcttcct gcttcgtttc catggtcact gggatttgca ggtgtgagct gagccaccac
     1501 accctgctga tttgctaccg tttattttct caagacaagg gtttctctgt gtagccctgg
     1561 ctgtcctaga actcatgctg tagaccaagc tggcctcaag ctctgagatc tgcctgcttc
     1621 tgcctcccaa agtgttggaa atgtatgcta tcccaagtga aaaccattat caaattaata
     1681 aatttgaact tctcagtg
//
LOCUS       NM_001436530            2205 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), transcript variant 2, mRNA.
ACCESSION   NM_001436530 XM_006243487
VERSION     NM_001436530.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006243487.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.55627.1,
                                           SRR26360190.2604982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000008.1  96988079-96988151
            74-218              JAXUCZ010000008.1  96988308-96988452
            219-331             JAXUCZ010000008.1  97006495-97006607
            332-465             JAXUCZ010000008.1  97007968-97008101
            466-565             JAXUCZ010000008.1  97016484-97016583
            566-2205            JAXUCZ010000008.1  97022942-97024581
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2205
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..73
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            74..218
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            219..331
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    312..314
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="upstream in-frame stop codon"
     exon            332..465
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..956
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001423459.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     misc_feature    378..635
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     misc_feature    378..635
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     exon            466..565
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            566..2205
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccactgg cggtggcggc acagcagcgg tgaggctcgc gcaccggagg agctggaccg
       61 tgtaaagcct gcgggccccc aagttcgaag cctgccttgc tgctgaagtc agcccttccg
      121 gcctgaggag tcagcaaatc ctggatatag cttctcgggc tgagctgagc atccaggggg
      181 catagggcgc cacgacccag ccacaccctc tgctgcaggg gaacgactta attcctgaca
      241 ctggcaggta tctgggccct ggcagttaac tctttggaca ttgtgaattg gatacgctgt
      301 gaagggctct ctgaccagca ttgcaaacta ggatggagat gtctgcccag aggctgactt
      361 ctaacagaac atccccacag tcaccatcta actctgacta tacctgggaa tacgagtact
      421 atgagatcgg accggtttcc ttcgaaggac tgaaggctca caaatattcc atcgtgattg
      481 gattctgggt tggtcttgcg gtctttgtga ttttcatgtt ttttgtgctg actttgctga
      541 caaagacagg cgccccacac caagacaatg cggagtcctc agagaagagg ttccgaatga
      601 acagctttgt gtcagacttt gggaagcccc tggagtcaga caaggtgttt tctcgtcagg
      661 gcaatgagga gtccaggtct ctgttccact gttacatcaa tgaagtggaa cacttggaca
      721 gggttaaagt ttgccaccga acaacagcca ttgacagcga tgtccatctc caggaagcca
      781 tcagaagcag tgggaggcct gaggaggagc taaccaggtt tatgcagttt gacatcccca
      841 acttcgtgaa cacagaccag aactcctttg gggaggatga tcttcttatt tcggaaccac
      901 ctgttcttct agaaaataag ccagtttccc agacatcacg tacagacctg gactgagaca
      961 cacttgtggg tgccttcctg aggatgtgtt ctgtttctgt gcagcaagaa accacatgct
     1021 acctacactt gtgtgtgtgt gtgtggagag agagagagag agagagagag ggagggagag
     1081 agagagagag agagaggggg agggaggagg cggcagcggg tggggaagag gatgatgttt
     1141 aaagtttaag acctaggcta ggactgggat ttagtgatag aggggcagaa tttgaagatg
     1201 ggaggcacca ttttgatttg gggagggtga tttttttctc tttggattaa aaatgccttg
     1261 acagtattaa agcttcttta ttgaaacgat tagccaacac atgcaattga gctccctcct
     1321 gggtgagggc tagttcgctg cagtcgggtc tagccctttc ccaccatcct ctgcctgtaa
     1381 caagctgctt tgcctctctg gactgccatg gctttacagg taaggtggcc tgtccggagt
     1441 agatgaccta tcccagctct agaattttgt gactttcaaa cttagctata agataagcta
     1501 agaaacgcat aagcagtaga aaataccaca cggcatcgag gctttcatgg caggttcttc
     1561 aggtctcggt gctctccctt cactcagtcc ttcactgggt cacactttcg gtagggaaat
     1621 ctttactagg agaccaggag acatgagact tgcacgcact gtggacagtg tctctgctgg
     1681 gtgttgctac agcaatttat gtgctgaacg cccccccccc ccgctttaaa ctgggatagc
     1741 ttcgactcca gcgactacca gcccaaactg ttttcacaag catctgtgct cttgaagaat
     1801 ggtagagcag attgttattt ggctgatgtg agtcccttct ggatgtccct gtgtttgcat
     1861 ccctgggctc acccttctga actatttggc ttcagaacag gaagataccg ctcgccatgt
     1921 ctgcgtggca gatgtgtagg tgacggctgc ctggcttgga gctgagaggg tccgtgggtt
     1981 ttttgccaca gtaacagatg ttcaggattg gaggatgtta atatgagcca catgatgtcc
     2041 gtctcacaaa gcaagcagcc ccctttgctg gagtcagaaa caacccagtc ctgcacacac
     2101 agagttgtac gcatgagcag ctgctaatct ctgggtggca tcttctttat gaatttgttc
     2161 accatttgtc ttgcttaagt tgcaaaataa atgcatttga tcgca
//
LOCUS       NM_001436537            1722 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus nei-like DNA glycosylase 1 (Neil1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436537 XM_039081874
VERSION     NM_001436537.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Ma,H., Wang,J., Abdel-Rahman,S.Z., Hazra,T.K., Boor,P.J. and
            Khan,M.F.
  TITLE     Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced
            splenic toxicity
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 1-7 (2011)
   PUBMED   21145906
  REMARK    GeneRIF: In the spleen aniline-induced oxidative stress is
            associated with an induction of NEIL1/2.
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Das,A., Boldogh,I., Lee,J.W., Harrigan,J.A., Hegde,M.L.,
            Piotrowski,J., de Souza Pinto,N., Ramos,W., Greenberg,M.M.,
            Hazra,T.K., Mitra,S. and Bohr,V.A.
  TITLE     The human Werner syndrome protein stimulates repair of oxidative
            DNA base damage by the DNA glycosylase NEIL1
  JOURNAL   J Biol Chem 282 (36), 26591-26602 (2007)
   PUBMED   17611195
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039081874.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11283.1,
                                           SRR26643292.33806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000008.1  66452113-66452196   c
            85-541              JAXUCZ010000008.1  66450320-66450776   c
            542-661             JAXUCZ010000008.1  66448599-66448718   c
            662-725             JAXUCZ010000008.1  66448447-66448510   c
            726-825             JAXUCZ010000008.1  66448117-66448216   c
            826-953             JAXUCZ010000008.1  66447489-66447616   c
            954-981             JAXUCZ010000008.1  66447254-66447281   c
            982-1043            JAXUCZ010000008.1  66447036-66447097   c
            1044-1200           JAXUCZ010000008.1  66446761-66446917   c
            1201-1722           JAXUCZ010000008.1  66446106-66446627   c
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1722
                     /gene="Neil1"
                     /note="nei-like DNA glycosylase 1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
     exon            1..84
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    15..17
                     /gene="Neil1"
                     /note="upstream in-frame stop codon"
     exon            85..541
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1271
                     /gene="Neil1"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 1; nei endonuclease
                     VIII-like 1"
                     /codon_start=1
                     /product="endonuclease 8-like 1"
                     /protein_id="NP_001423466.1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
                     /translation="MPEGPELHLASHFVNEICKGLVFGGCVEKSSVSRNPEVPFESSA
                     YHISALARGKELRLTLSPLPGSHPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFY
                     TAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRLSPELTLSQKVKA
                     KLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYAVPGMSSLRDRHG
                     RTIWFQGDPGPLAPKGGRSRKKKSQETQLEAEDRKEDPPSKSISRTQRARKHCPKNVP
                     QQSEGASLPQNLETPAVPEKGKRRGRRASTGRHRGPKSKPDTQPREAGEISAS"
     misc_feature    108..488
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    108..488
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    order(111..116,267..269,339..341,345..353,390..395)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    order(111..116,267..269,339..341,345..353,390..395)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    111..113
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    111..113
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(114..125,129..134,141..143,258..272)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(114..125,129..134,141..143,258..272)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(114..116,267..269)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(114..116,267..269)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    <261..>725
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    <261..>725
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    861..977
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     misc_feature    861..977
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     exon            542..661
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..725
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..825
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..953
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..981
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1043
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1200
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1722
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcctggct aggttaactg gtgacttcaa ctgcagacgc agctgcgact cctggcacca
       61 gttctgaccg aggctctgct caccggccca gccattcctc cttcagaatg ccggagggcc
      121 cagagctgca cctggccagc cactttgtga atgagatatg taaagggctg gtattcggtg
      181 ggtgtgtgga gaagtcctct gtcagccgaa acccggaggt gccctttgag agcagtgcct
      241 accacatctc agctttagcc cgaggcaagg agctgcgctt gacattgagc cccctgcctg
      301 ggtcccatcc ccctcagaaa ccactgtccc ttgtcttccg ctttggtatg tctggatcct
      361 tccagctggt acccgcagaa gcactgccgc gccacgccca tctacgtttc tatacggccc
      421 cacctgcccc ccggcttgcc ctttgcttcg tagacatccg ccgctttggc cactgggacc
      481 ctggaggtga atggcagcca ggccgcggac cctgtgtctt gttggagtat gaacggttca
      541 gagagaacgt gcttcggaac ctatcggaca aagcctttga ccggcccatc tgcgaggcct
      601 tgttggacca gaggttcttc aatggaatcg gcaactatct gcgggcagag atcttgtatc
      661 ggctgaagat cccccctttt gagaaggccc gtacagttct agaggccctg caacagtgcc
      721 ggctgagccc agagctgacc ctgagccaga aggtcaaggc caaactgcag aacccagacc
      781 tgctggaact gtgtcacttg gtgcccaagg aagtggttca gctggggggc aaaggctatg
      841 ggccagagcg tggagaggaa gattttgctg cctttcgagc ctggcttcgg tgctatgctg
      901 tgccaggcat gagctccctg agagaccggc atggccgtac catttggttc cagggtgatc
      961 ctggaccctt ggcacccaaa gggggcagat cccgaaaaaa gaagtcacag gaaacacagc
     1021 tggaggctga ggacagaaaa gaggaccctc caagcaagtc catttccagg actcagaggg
     1081 ccaggaagca ctgtcctaag aatgtacctc aacagtctga aggggccagc ctcccacaaa
     1141 acctggaaac ccctgcagtc cctgagaaag gaaagagaag ggggagacgg gcgagcacag
     1201 gccgccacag aggaccaaag agtaagcctg atactcaacc cagggaggct ggggagattt
     1261 cagcctcata ggtagaggta tccttccctg atgacttgct atcaatctag gggaatgtct
     1321 gaatccctag aaccagtatt tgtagggcta catgccctgg gccctgtgat ttttttcctg
     1381 cacaactgtt gtctgaggtg gggtctcctg tgtcctatcc ttgaatccat atgtacctga
     1441 agatgacatt gaactcctcc tgtttgatct tcctgcttcg tttccatggt cactgggatt
     1501 tgcaggtgtg agctgagcca ccacaccctg ctgatttgct accgtttatt ttctcaagac
     1561 aagggtttct ctgtgtagcc ctggctgtcc tagaactcat gctgtagacc aagctggcct
     1621 caagctctga gatctgcctg cttctgcctc ccaaagtgtt ggaaatgtat gctatcccaa
     1681 gtgaaaacca ttatcaaatt aataaatttg aacttctcag tg
//
LOCUS       NM_031689                805 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus crystallin, beta A4 (Cryba4), mRNA.
ACCESSION   NM_031689
VERSION     NM_031689.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 805)
  AUTHORS   Li,W., Ji,Q., Wei,Z., Chen,Y.L., Zhang,Z., Yin,X., Aghmiuni,S.K.,
            Liu,M., Chen,W., Shi,L., Chen,Q., Du,X., Yu,L., Cao,M.J., Wang,Z.,
            Huang,S., Jin,T. and Wang,Q.
  TITLE     Biochemical characterization of G64W mutant of acidic
            beta-crystallin 4
  JOURNAL   Exp Eye Res 186, 107712 (2019)
   PUBMED   31254514
REFERENCE   2  (bases 1 to 805)
  AUTHORS   Billingsley,G., Santhiya,S.T., Paterson,A.D., Ogata,K., Wodak,S.,
            Hosseini,S.M., Manisastry,S.M., Vijayalakshmi,P., Gopinath,P.M.,
            Graw,J. and Heon,E.
  TITLE     CRYBA4, a novel human cataract gene, is also involved in
            microphthalmia
  JOURNAL   Am J Hum Genet 79 (4), 702-709 (2006)
   PUBMED   16960806
REFERENCE   3  (bases 1 to 805)
  AUTHORS   Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
  TITLE     Lens proteomics: analysis of rat crystallin sequences and
            two-dimensional electrophoresis map
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
   PUBMED   11773034
REFERENCE   4  (bases 1 to 805)
  AUTHORS   Takeuchi,N. and Kamei,A.
  TITLE     Crystallin proteins in lenses of hereditary cataractous rat, ICR/f
  JOURNAL   Biol Pharm Bull 23 (3), 283-290 (2000)
   PUBMED   10726880
REFERENCE   5  (bases 1 to 805)
  AUTHORS   David,L.L. and Shearer,T.R.
  TITLE     Beta-crystallins insolubilized by calpain II in vitro contain
            cleavage sites similar to beta-crystallins insolubilized during
            cataract
  JOURNAL   FEBS Lett 324 (3), 265-270 (1993)
   PUBMED   8405363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_031689.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013247.1, SRR26360194.513503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093047 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000012.1  50047046-50047071
            27-77               JAXUCZ010000012.1  50047919-50047969
            78-196              JAXUCZ010000012.1  50048630-50048748
            197-338             JAXUCZ010000012.1  50050204-50050345
            339-481             JAXUCZ010000012.1  50051837-50051979
            482-805             JAXUCZ010000012.1  50053313-50053636
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..805
                     /gene="Cryba4"
                     /note="crystallin, beta A4"
                     /db_xref="GeneID:64348"
                     /db_xref="RGD:61962"
     exon            1..26
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
     exon            27..77
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Cryba4"
                     /note="upstream in-frame stop codon"
     CDS             39..629
                     /gene="Cryba4"
                     /note="beta-A4 crystallin"
                     /codon_start=1
                     /product="beta-crystallin A4"
                     /protein_id="NP_113877.1"
                     /db_xref="GeneID:64348"
                     /db_xref="RGD:61962"
                     /translation="MTLQCTKSAGHWRVVVWDEEGFQGRRHEFTAECPSVLDLGFETV
                     RSLKVLSGAWVGFEHAGFQGQQYVLERGDYPGWDAWGGNTAYPAERLTSFRPVACANH
                     RDSRLTIFEQENFLGRKGELSDDYPSLQAMGWDGTEVGSFHVQSGAWVCSQFPGYRGF
                     QYVLESDHHSGDYKHFREWGSHAHTFQVQSVRRIQQ"
     misc_feature    42..71
                     /gene="Cryba4"
                     /note="propagated from UniProtKB/Swiss-Prot (P56374.2);
                     Region: N-terminal arm"
     misc_feature    42..44
                     /gene="Cryba4"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000269|PubMed:11773034; propagated from
                     UniProtKB/Swiss-Prot (P56374.2); acetylation site"
     misc_feature    75..329
                     /gene="Cryba4"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     misc_feature    75..329
                     /gene="Cryba4"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     misc_feature    333..350
                     /gene="Cryba4"
                     /note="propagated from UniProtKB/Swiss-Prot (P56374.2);
                     Region: Connecting peptide"
     misc_feature    354..620
                     /gene="Cryba4"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     misc_feature    354..620
                     /gene="Cryba4"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     exon            78..196
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
     exon            197..338
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
     exon            339..481
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
     exon            482..805
                     /gene="Cryba4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacatgtg ctctgggccc ttcttggact gagccaacat gaccctgcag tgcaccaagt
       61 cagctggaca ctggagggtg gtggtgtggg acgaagaagg cttccagggt cgtcggcatg
      121 aattcacagc tgagtgtccc agcgtgctgg atctcggctt tgagaccgtg cgatcactga
      181 aagtcctgag cggagcgtgg gtgggctttg agcacgctgg cttccaaggg cagcaatatg
      241 tgctggagag gggcgattac ccaggctggg acgcctgggg tggcaacaca gcctaccccg
      301 ccgagaggct cacctccttc cggcctgtgg cctgcgctaa ccaccgcgac tcaaggctga
      361 ccatcttcga gcaggagaac ttcctgggca ggaaaggcga gctgagtgac gactatccct
      421 ctctgcaggc catgggctgg gacggcactg aagtgggctc cttccatgtt cagtctggcg
      481 cgtgggtttg ttcccagttt cctggttacc gaggttttca gtacgtgctg gagagcgatc
      541 accactcggg tgactacaag cacttcaggg agtggggctc ccatgcccac accttccagg
      601 tgcagagtgt gcgcaggatc cagcagtgag agcgcacaag tgacctgggg tgcctgcaaa
      661 acgactgagt gactggccgg aggatgtggc tgctcttggt tctggctacc cctgtgtcct
      721 ctgggaaccc cacacccctg tcagccagcc cattccctgc cagctcacga agctcaaaga
      781 aataaaatta aaaacaaaag actca
//
LOCUS       NM_001436424            4223 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus STAG3 cohesin complex component (Stag3),
            transcript variant 2, mRNA.
ACCESSION   NM_001436424 XM_006249020
VERSION     NM_001436424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   2  (bases 1 to 4223)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 4223)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   4  (bases 1 to 4223)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
REFERENCE   5  (bases 1 to 4223)
  AUTHORS   Lee,J. and Hirano,T.
  TITLE     RAD21L, a novel cohesin subunit implicated in linking homologous
            chromosomes in mammalian meiosis
  JOURNAL   J Cell Biol 192 (2), 263-276 (2011)
   PUBMED   21242291
REFERENCE   6  (bases 1 to 4223)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   7  (bases 1 to 4223)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   8  (bases 1 to 4223)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   9  (bases 1 to 4223)
  AUTHORS   Bayes,M., Prieto,I., Noguchi,J., Barbero,J.L. and Perez Jurado,L.A.
  TITLE     Evaluation of the Stag3 gene and the synaptonemal complex in a rat
            model (as/as) for male infertility
  JOURNAL   Mol Reprod Dev 60 (3), 414-417 (2001)
   PUBMED   11599053
REFERENCE   10 (bases 1 to 4223)
  AUTHORS   Pezzi,N., Prieto,I., Kremer,L., Perez Jurado,L.A., Valero,C., Del
            Mazo,J., Martinez-A,C. and Barbero,J.L.
  TITLE     STAG3, a novel gene encoding a protein involved in meiotic
            chromosome pairing and location of STAG3-related genes flanking the
            Williams-Beuren syndrome deletion
  JOURNAL   FASEB J 14 (3), 581-592 (2000)
   PUBMED   10698974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006249020.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000012.1  22398299-22398391
            94-267              JAXUCZ010000012.1  22399756-22399929
            268-364             JAXUCZ010000012.1  22401297-22401393
            365-484             JAXUCZ010000012.1  22401672-22401791
            485-581             JAXUCZ010000012.1  22407696-22407792
            582-658             JAXUCZ010000012.1  22408708-22408784
            659-863             JAXUCZ010000012.1  22409067-22409271
            864-1015            JAXUCZ010000012.1  22409670-22409821
            1016-1089           JAXUCZ010000012.1  22414638-22414711
            1090-1213           JAXUCZ010000012.1  22415504-22415627
            1214-1312           JAXUCZ010000012.1  22416126-22416224
            1313-1392           JAXUCZ010000012.1  22416419-22416498
            1393-1500           JAXUCZ010000012.1  22416862-22416969
            1501-1615           JAXUCZ010000012.1  22417168-22417282
            1616-1721           JAXUCZ010000012.1  22417405-22417510
            1722-1825           JAXUCZ010000012.1  22417734-22417837
            1826-1918           JAXUCZ010000012.1  22418090-22418182
            1919-2008           JAXUCZ010000012.1  22418294-22418383
            2009-2209           JAXUCZ010000012.1  22418601-22418801
            2210-2280           JAXUCZ010000012.1  22418902-22418972
            2281-2368           JAXUCZ010000012.1  22419070-22419157
            2369-2446           JAXUCZ010000012.1  22419732-22419809
            2447-2539           JAXUCZ010000012.1  22419887-22419979
            2540-2708           JAXUCZ010000012.1  22420097-22420265
            2709-2845           JAXUCZ010000012.1  22420375-22420511
            2846-2947           JAXUCZ010000012.1  22421314-22421415
            2948-3096           JAXUCZ010000012.1  22423117-22423265
            3097-3225           JAXUCZ010000012.1  22423448-22423576
            3226-3383           JAXUCZ010000012.1  22423659-22423816
            3384-3618           JAXUCZ010000012.1  22425680-22425914
            3619-3720           JAXUCZ010000012.1  22426079-22426180
            3721-3793           JAXUCZ010000012.1  22426433-22426505
            3794-3865           JAXUCZ010000012.1  22427913-22427984
            3866-4223           JAXUCZ010000012.1  22428198-22428555
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..4223
                     /gene="Stag3"
                     /note="STAG3 cohesin complex component"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
     exon            1..93
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    17..19
                     /gene="Stag3"
                     /note="upstream in-frame stop codon"
     exon            94..267
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3874
                     /gene="Stag3"
                     /note="cohesin subunit SA-3-like; SCC3 homolog 3;
                     stromalin-3; stromal antigen 3"
                     /codon_start=1
                     /product="cohesin subunit SA-3"
                     /protein_id="NP_001423353.1"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
                     /translation="MPTLWSPSTQHHGSSSGSMSSPLRKSVRCAQMALSPCSSNIQPC
                     DDRDSQGTAEWDSSSTSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPGG
                     NDKNKSVPPTSDLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKS
                     TVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQ
                     YSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQ
                     RQYEAERNKGPEQRAPERLESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPE
                     IRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELS
                     SRMELFTNRFKDRMVSMVMDRESEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYI
                     SNRAMASSAGEFVYWKIFHPECGAKAVSGRERRRSPQAQRTFIYLLLAFFMESEHHDH
                     AAYLVDSLWDCAGSYLKDWESLTSLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPP
                     VGRITGKKSLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAENVAPLLRLLSYFD
                     LNIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFAR
                     SQLVDLLTDRFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCS
                     RLLRKAVDTGEVPHQVILPALTLVYFSILWTVTHISESTSQKQLMSLKKRMVAFCELC
                     QSCLSDVDPEIQEQAFVLLSDLLLIFSPQMVVGGRDFLRPLVFFPEATLQSELASFLM
                     DHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNK
                     FYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQDLTELPAFIEMR
                     DLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSREPPNIAFLELLSEFS
                     PRLFHQDKQLLLSYLEKCLQRVSMAPSHPWGPVTTYCHSLHLVENTAEASSQGPPHSK
                     KRCIEVPRRLQEEESSSQGESLQLNSGPTTPTLTSTAVKRRQSPRTVGKRQKGGPGPG
                     PGPGPGPGPGPGPGPGPGPGPELICSQQLSGTQRLKMSSAPCFQIRCDPSGSGLGKQM
                     TRLSLMEEDEEEELRLLDEEWQCGDKLLHSPSSPSEHGLDLLDTTELNMEDF"
     misc_feature    104..433
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    407..>1381
                     /gene="Stag3"
                     /note="Cohesin [Cell division and chromosome
                     partitioning]; Region: IRR1; COG5537"
                     /db_xref="CDD:227824"
     misc_feature    407..>1381
                     /gene="Stag3"
                     /note="Cohesin [Cell division and chromosome
                     partitioning]; Region: IRR1; COG5537"
                     /db_xref="CDD:227824"
     misc_feature    665..1006
                     /gene="Stag3"
                     /note="STAG domain; Region: STAG; pfam08514"
                     /db_xref="CDD:462502"
     misc_feature    665..1006
                     /gene="Stag3"
                     /note="STAG domain; Region: STAG; pfam08514"
                     /db_xref="CDD:462502"
     misc_feature    3389..3610
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3791..3871
                     /gene="Stag3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3803..3805
                     /gene="Stag3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O70576; propagated from
                     UniProtKB/Swiss-Prot (Q99M76.1); phosphorylation site"
     exon            268..364
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..484
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..581
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..658
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..863
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1015
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1089
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1213
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1312
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1392
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1500
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1615
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1721
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1825
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1918
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2008
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2209
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2280
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2368
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2446
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2539
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2708
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2845
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2947
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3096
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3225
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3383
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3618
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3720
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3793
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3865
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4223
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttacccgccc tccacctgag gaagaggagc cgctgcggcg ggcgtctcgc ttcagaggtg
       61 ggatgtccac agagatctga aaggacccct gagctggatt aacatgccta ctctgtggtc
      121 accctccacc cagcaccatg gctcttcctc aggcagtatg tcctcccctc ttcgaaagtc
      181 tgtgagatgt gcacagatgg ccttgtctcc ttgttcttcc aacatccaac cctgtgatga
      241 cagagactcc cagggaactg cagaatggga tagttcctca actagtgaag acagtgactt
      301 tgaagatagc ttaagaagaa atgtgaggaa gagagcagca aaacgaccac ccaaagctat
      361 cccagtggca aaacatccga agaagcagtc ccacatagta cctggtggga atgacaagaa
      421 caagtcagtg ccgccaacca gtgacctttt tgatgctgtg aaagctgcta gaagttgtgc
      481 gcagtctttg gtagatgagt ggctagaaaa ctacaagcaa gatgaaaatg caggattctt
      541 ggaacttgtt aattttttca tccgagcctg tggatgtaaa agcactgtca cacccgagat
      601 gttcaagaca atgtccaact cagagatcat ccagcaccta acagaagagt ttaatgagga
      661 ctcaggtgac tatcccctga cagctccagg tccatcctgg aagaagttcc agggaagctt
      721 ctgtgagttt gtgaagacac tagtctgtca gtgccagtac agcctcctct ttgacggctt
      781 tccaatggat gaccttatct ccctgctcat tggcctctca gattcccagg tccgagcctt
      841 tcgtcatact agtactttgg ctgccatgaa gctaatgact tctctggtaa aagttgcact
      901 ccagttgagt ctgcacaaag acaacaatca acgtcagtat gaggcagaac gaaacaaggg
      961 gccagagcag agggcaccag agcggctcga gagtctgctg gagaaacgaa aagagttcca
     1021 agagaatcaa gaggagatag aggggatgat gaatgccatc ttcaggggtg tctttgttca
     1081 tcggtacagg gacatccttc ctgagatccg tgctgtctgc atcgaggaga tcgggtgttg
     1141 gatgcaaagc tacagcacct cctttcttaa tgacagctac ctaaaatata ttggctggac
     1201 cctgcatgac aagcacaagg aagtccgcct aaagtgtgtg aaggctctgg cagggctgta
     1261 cagcaaccag gagctgagtt cacggatgga gctctttact aatcgcttca aggaccggat
     1321 ggtttccatg gtcatggaca gagagagtga agtagcagtg gaggccatca gattgctgac
     1381 ccttattctg aagaacatgg agggagtact gactagtgca gattgtgaga aaatttactc
     1441 cattgtatac atttctaatc gtgccatggc ctcttctgca ggggaatttg tgtactggaa
     1501 gattttccat cctgaatgtg gggcaaaagc agtgagtggc agggagcgac gccggagtcc
     1561 acaagcccag aggactttca tttacctttt attggccttc tttatggaga gtgagcatca
     1621 cgaccatgct gcttacctag ttgacagctt gtgggactgt gcagggtctt acctgaagga
     1681 ctgggagagt ctgacaagtc tgttgctgca gaaagaccag aatctgggtg atatgcaaga
     1741 gagaatgttg atagaaatcc tggtgtccag tgcccggcaa gctgcagagg gtcacccacc
     1801 agtggggcgc atcactggaa agaagagtct gaccgccaaa gaacgcaagc ttcaagctta
     1861 tgataaggtg aagctggctg agcacctcat ccccctcttg ccccagctcc ttgccaagtt
     1921 ctcagcagat gcagagaacg ttgctccctt gctccggctg ctcagttact ttgacctcaa
     1981 catttattgc actcagcgct tggagaagca cttggagctg cttctgcaac aactccagga
     2041 ggtggtggtg aagcacgtag agcctgaggt gcttgaggct gcagcacatg ccctctattt
     2101 gctctgcaag ccagagttca ccttcttcag cagagtggac ttcgccagaa gccaattagt
     2161 agatctgctg actgatagat tccagcagga gcttgacgac ctaatgcagt catccttcct
     2221 agatgaggat gaggtataca gtctgacagc cactctgaag cgtctctctg ccttttacaa
     2281 tgctcatgac ctgactcgct gggagatctc tgaaccatgt tctcgactcc tccggaaggc
     2341 tgtagacaca ggagaagttc ctcaccaggt gattttgcca gccttgactc tggtatattt
     2401 ttccattctc tggacagtga cccacatttc agagtctact tcccaaaagc agctgatgag
     2461 tctgaagaaa agaatggtag ccttctgtga actttgccaa agctgcctct cagacgtgga
     2521 cccagagatc caggagcagg cttttgtttt attaagtgac ctgcttctca tcttcagccc
     2581 ccagatggtt gtagggggcc gggatttcct taggcctctt gtcttttttc cggaagctac
     2641 tctccagtcg gaactagcca gcttcctcat ggaccatgtc tttctccagc ctggagaatt
     2701 gggcaacggt caatcacagg aggatcacgt ccaaatagag cttctgcacc agaggcgccg
     2761 cctgcttgca ggattttgta agctgttgct ttatggggta ttggaactgg atgcggcctc
     2821 agatgttttc aaacactaca acaagttcta tgaagattat ggtgacatta tcaaggaaac
     2881 attaactcgg gcgagacaaa ttgaccgatg tcagtgctct cggatcctgc tcctgagcct
     2941 aaagcagctc tacacagaac tgatacagga gcaggggccc caggacctga cagaactgcc
     3001 agccttcatt gagatgagag acctggcccg gaggtttgcc ttgagctttg gaccccagca
     3061 gctccataac agagatcttg tggtcatgct gcacaaggaa ggcatcaagt tctcattgtc
     3121 tgagcttcct cctgctggct cttctcgaga gcccccaaat attgcattcc tggagcttct
     3181 ttcagagttc tccccccgcc tcttccatca ggacaaacag ctactactat catacctgga
     3241 aaagtgtctg cagcgtgtct ccatggcacc tagccatccc tggggtccag tcaccaccta
     3301 ctgccactcc ctccatctag tagagaacac agcagaggcc agctctcagg ggccccccca
     3361 ctccaagaag aggtgtattg aagttccccg caggcttcag gaagaagagt cttcatccca
     3421 gggagaaagc cttcagctga acagtggccc cacaacacct acactcacct ccacagcagt
     3481 gaagagaagg cagtctccga ggacagtagg caagaggcaa aaaggtggac caggaccagg
     3541 accaggacca ggaccaggac caggaccagg accaggacca ggaccaggac caggaccagg
     3601 accagagctg atctgcagtc agcagctctc aggcacccag aggttgaaaa tgtcgagtgc
     3661 accgtgtttc cagattcgat gtgatccttc tggctctggc ttgggcaagc agatgacccg
     3721 actcagcctt atggaagaag atgaggaaga agagctgaga cttctggatg aagaatggca
     3781 atgtggagac aagctacttc atagcccttc ttctcccagt gagcatgggc tggacctatt
     3841 agatacaaca gagctgaaca tggaggattt ctgatgggac ttaggcttct ccccttctcc
     3901 acttaccaca ctgcaaggcc atgagtgagc aaacgaagga gtaaaatgaa gcattctttg
     3961 ggtcccagcc aagtacttta agggaataga gaaatggcct tattcaaacc tccatttctt
     4021 tctgaagtgg gtgctgtata tagatgctat gagccctgtg atccttaatt caccctagct
     4081 ttatgctttt gcctgtttga agtggtggga gttgggtagg gagctttacc tcagtattga
     4141 agtttaataa accttctgtt tgatatctct tccccaaaca ctgccaagct ctcaataaac
     4201 atgttcacat cagctatttc ata
//
LOCUS       NM_001109528            2539 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 25 (Tmem25), transcript
            variant 3, mRNA.
ACCESSION   NM_001109528 XM_001060928
VERSION     NM_001109528.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Zhang,H., Tian,X., Lu,X., Xu,D., Guo,Y., Dong,Z., Li,Y., Ma,Y.,
            Chen,C., Yang,Y., Yang,M., Yang,Y., Liu,F., Zhou,R., He,M., Xiao,F.
            and Wang,X.
  TITLE     TMEM25 modulates neuronal excitability and NMDA receptor subunit
            NR2B degradation
  JOURNAL   J Clin Invest 129 (9), 3864-3876 (2019)
   PUBMED   31424425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001060928.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132308, SAMEA5760393
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2539
                     /gene="Tmem25"
                     /note="transmembrane protein 25"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
     exon            1..112
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    89..91
                     /gene="Tmem25"
                     /note="upstream in-frame stop codon"
     exon            113..206
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1234
                     /gene="Tmem25"
                     /codon_start=1
                     /product="transmembrane protein 25 precursor"
                     /protein_id="NP_001102998.1"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
                     /translation="MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRE
                     NEHHAFTCRVAGGSATPRLAWYLDGQLQKATTSRLLSVGGDAFSGGTSTFTVTAQRSQ
                     HELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPP
                     ANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTS
                     ASLPAPGLLATRIEVPLLGIVVAGGLAFGTLVGFSTLVACLVCRKEKKTKGPSRRPSL
                     ISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDIRGKATERPMAQHSSRPELLEAEP
                     GGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL"
     sig_peptide     137..214
                     /gene="Tmem25"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    215..490
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    215..490
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    278..292
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    278..292
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    320..334
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    320..334
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    407..418
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    407..418
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    446..463
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    446..463
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     exon            207..518
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            519..809
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            810..941
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            942..972
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1073
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1160
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..2539
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagggagcc aggtgagctg cctggaaagc tggatgctcc aatgaccccc gggtccgcga
       61 cgctctcttg ctaggcccaa ttccatgttg aacagttgag attggaaaag ggcctggagg
      121 ccagtccctg atcaccatgg agttgcctct aagccaagct acgctccggc atactctgct
      181 gctcctgcct gccctcttaa gttcaggtca aggagagctg gcgccacaaa ttgatggtca
      241 gacctgggct gagagagcac ttagggaaaa tgagcaccat gctttcacct gtcgggttgc
      301 agggggttct gccactcccc gattagcctg gtacctggat ggacagctac agaaggctac
      361 cacctcgcga ctcctgagtg tgggcgggga cgccttctct ggaggtacca gcactttcac
      421 tgtcactgcc cagcgctccc aacatgagct taactgctcc ctgcaggacc cagggagtgg
      481 ccggccagcc aatgcctctg tcattctcaa tgtgcaattc aaaccagaga ttgcccaggt
      541 tggagccaag taccaggaag ctcagggccc aggccttctg gttgtcctgt ttgccctggt
      601 acgggccaac ccacctgcca atgtcacctg gattgaccag gatgggccag tgactgtcaa
      661 tgcctctgac ttcctggtgc tggatgccca gaactatccc tggctcacca accacactgt
      721 gcagctgcag ctccgaagcc tggcacacaa cctctcggtg gtggccacca acgatgtggg
      781 tgtcaccagt gcctcacttc cagctccagg gctcctggcc acacggatag aagtgccact
      841 gctgggcatc gttgtggctg gaggacttgc ctttggcact ctagtgggat tcagtacctt
      901 ggtggcctgc ctggtctgca ggaaagagaa gaaaacaaaa ggcccctccc ggcgtccttc
      961 tctgatatct agtgactcca ataacctgaa actgaataat gtgcgcctgc cccgggagaa
     1021 catgtccctc ccatccaacc ttcagctcaa tgacctcact ccggatatca gagggaaagc
     1081 aacagagcgg ccaatggctc agcatagcag ccgtccagag cttctagaag cggagcctgg
     1141 tggcctcctc accagccgag gtttcatccg tctcccaatg ttgggctaca tctaccgtgt
     1201 gtccagcgta agcagtgatg agatttggct ctgagcttga gagtgaggca gatggcccag
     1261 gtggtctgtg gactccccag agtgaccacc ccttcttgaa gcatcttctt caagcttccc
     1321 tctgcctggc cctgttgtga ccatgaagaa accatgtcac tgccgtctgg cctgcctggc
     1381 aaggatacct gtgggtcatg catgtgtatg tcattgcact ctaacctgca agacatgggt
     1441 acccttggca aggccacggg tcagaactaa gccccttgca ctcactcagt ttggggccct
     1501 gcatgtgata acctggtcca ggcagacgga actctggcca ggtgtgttta gatgtcaccc
     1561 gacacctaaa agacgggcct atttattata cgtcccacgc cagtatccac tgcaccttgt
     1621 gtgcagagag atgcctatgc aggggacccc gcacaactca gatgacagcc ttcctttgct
     1681 atgcagcctt gttccctcag ggaaaacata gcccctgcta ttgtatagaa ccaaattgcc
     1741 ctttgctcag gaaccagccc ctcacccagg gacctggcca agcacaaatt cgtccctttt
     1801 gctgcaacat atctttctac tcttctatcc ccacttcctc ttggtcatca taggtcatac
     1861 cctagacctt cttcactgag tattagacct ccattggctg gggcccatgg gtgcagcctt
     1921 tggtgttagc acaagatgag caagaagagg tgacaggagg gctggctccc aagacagcat
     1981 gtagcaatgt atcattttgt acagtgtcct catattaagc acattctcca ggagcgagga
     2041 gggcccaggg ccttcttggg ttccccatct ttggccttca gcaattcact gtgagtgttc
     2101 tgagcactca gggttggtgg tttcctctct gcatgtctct tcccaccatg cagccacatt
     2161 cctgaccaaa cctggctgcc acatcctatt cttccaggga tggtcacagt gggtatagaa
     2221 cccaacagcg ccagaagctt taggggaaca gagggagcag gagcccacac agctctaaag
     2281 agctaagaat acttttaaaa aagcaacatg aaaatggcaa acaggggttg gggatttagc
     2341 tcagtggtag agcgcttgcc tagcaagcgc aaggccctgg gttcagtccc cagctctgga
     2401 aaaaaaaaaa aaaaaaaaga aagaaaatgg caaacagcag agtatggagt ctattttcct
     2461 ttcttcatat cttgtttggt aatttttctt gtgttactgg tgagtactgt gctgcacaca
     2521 cagtaaattc ctttgacca
//
LOCUS       NM_001436461            5912 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus BCL2 interacting protein 2 (Bnip2), transcript
            variant 1, mRNA.
ACCESSION   NM_001436461 XM_006243370
VERSION     NM_001436461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5912)
  AUTHORS   Cho,B., Choi,S.Y., Park,O.H., Sun,W. and Geum,D.
  TITLE     Differential expression of BNIP family members of BH3-only proteins
            during the development and after axotomy in the rat
  JOURNAL   Mol Cells 33 (6), 605-610 (2012)
   PUBMED   22639046
REFERENCE   2  (bases 1 to 5912)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   3  (bases 1 to 5912)
  AUTHORS   Lu,M. and Krauss,R.S.
  TITLE     N-cadherin ligation, but not Sonic hedgehog binding, initiates
            Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4212-4217 (2010)
   PUBMED   20160094
REFERENCE   4  (bases 1 to 5912)
  AUTHORS   Oh,J.E., Bae,G.U., Yang,Y.J., Yi,M.J., Lee,H.J., Kim,B.G.,
            Krauss,R.S. and Kang,J.S.
  TITLE     Cdo promotes neuronal differentiation via activation of the p38
            mitogen-activated protein kinase pathway
  JOURNAL   FASEB J 23 (7), 2088-2099 (2009)
   PUBMED   19244314
REFERENCE   5  (bases 1 to 5912)
  AUTHORS   Sonn,S., Jeong,Y. and Rhee,K.
  TITLE     Nip2/centrobin may be a substrate of Nek2 that is required for
            proper spindle assembly during mitosis in early mouse embryos
  JOURNAL   Mol Reprod Dev 76 (6), 587-592 (2009)
   PUBMED   19117032
REFERENCE   6  (bases 1 to 5912)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006243370.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.319268.1,
                                           SRR26643429.30937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000008.1  79521377-79521565
            190-296             JAXUCZ010000008.1  79526784-79526890
            297-364             JAXUCZ010000008.1  79527506-79527573
            365-541             JAXUCZ010000008.1  79528505-79528681
            542-718             JAXUCZ010000008.1  79530492-79530668
            719-821             JAXUCZ010000008.1  79531627-79531729
            822-953             JAXUCZ010000008.1  79532710-79532841
            954-1040            JAXUCZ010000008.1  79534110-79534196
            1041-1139           JAXUCZ010000008.1  79534300-79534398
            1140-1175           JAXUCZ010000008.1  79535075-79535110
            1176-5912           JAXUCZ010000008.1  79537954-79542690
FEATURES             Location/Qualifiers
     source          1..5912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5912
                     /gene="Bnip2"
                     /note="BCL2 interacting protein 2"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
     exon            1..189
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..296
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1227
                     /gene="Bnip2"
                     /note="isoform 1 is encoded by transcript variant 1; Bcl-2
                     and E1B 19 kDa interacting protein; BCL2/adenovirus E1B
                     19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B
                     interacting protein 2; BCL2/adenovirus E1B 19 kDa
                     protein-interacting protein 2"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 2 isoform 1"
                     /protein_id="NP_001423390.1"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
                     /translation="MEGVELKEEWQDEDFPIPLPEDDSIEADILDVTDPDRQPGSLEV
                     NGNKVRKKLVAPDISLTLDPGEDSLWSDDLDEGGEVDLDGLDTPSENSDEFEWEDDLP
                     KPKTTEVIRKGSITEYAATEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYY
                     GDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIIYLNGATTRR
                     KMPSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVF
                     NLAELAELVPMEYVGIPECIKQYEEEKFKKRQKRVDQELNGKQEPPKSEQ"
     misc_feature    391..735
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    391..735
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    685..1131
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     misc_feature    685..1131
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     exon            297..364
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..541
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..718
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..821
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..953
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1040
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1139
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1175
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..5912
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgaatccg ggtcagctgc tgcctccggg actgcagctg agaccgtccg ggaaaagctg
       61 ggccccgtct ccacagccga ccaagggcag cgggctctgc ccggcgccac tttctgcgac
      121 ctggccgtca gccccacgtc gccggcctgg aggggcaaag aggacgaggg ggccgcggct
      181 tcctccgggg acctcggctg cctggattgc caggagctgg aagttgacat tgagtctagg
      241 ctgaggatgg aaggtgtgga actgaaagaa gaatggcagg atgaagactt cccaatacct
      301 ttaccagaag atgacagcat tgaagcagat atactagatg taactgatcc agacagacag
      361 cctggctcgt tagaagttaa tggaaacaaa gtacggaaga aactggtggc cccagacatc
      421 agcctgacct tggatcctgg tgaagactct ctgtggtcag atgatttgga tgaaggtgga
      481 gaagttgacc tggatggctt agacaccccc tcagagaaca gtgatgagtt tgagtgggaa
      541 gatgatcttc ccaaacccaa aactactgaa gtcattagga aaggctcaat tactgaatat
      601 gcagctacag aagaaaagga agatggacgc cgctggcgca tgttcaggat tggagagcag
      661 gaccatagag tggacatgaa ggcaatcgaa ccctacaaaa aagttattag ccatggaggc
      721 tattatgggg atggcttaaa tgccattgtt gtatttgctg tctgtttcat gcctgagagt
      781 ggtcagccta actatagata tttgatggac aatctcttta aatatgttat tggcacttta
      841 gagctgttgg tagcagagaa ctacatgatc atttacttaa atggtgcgac aacgcgaagg
      901 aaaatgccca gtctgggatg gctcaggaga tgctaccagc aaatcgacag acgattaagg
      961 aaaaacctaa agtctctaat cattgtgcac ccctcttggt ttatccgaac acttctggct
     1021 gttacaagac catttatcag ttcaaaattc agtcagaaga ttagatacgt ctttaatttg
     1081 gctgaactgg cggagcttgt tcccatggag tacgtcggca taccagagtg catcaaacag
     1141 tatgaagaag aaaagtttaa aaagagacaa aaaagagttg atcaagagct taatgggaaa
     1201 caggaaccac caaagagtga gcagtaagtt ccgcatccat cccggaggag gcagagcacc
     1261 gggggcaggg ctgtagtgca tcctagtgca ctgctggctc aagggtttat gtcatctgtt
     1321 acaaaattta cttgacttct ttccaaatga actcttgtac aagggactgt tcactgctgt
     1381 catggtttgc aactgttgaa tttagctctt taataactaa ttatattgta atcgttttat
     1441 attgctaaat agcaaaaact acactttata taaaacaatt tttacatttg tttatttgaa
     1501 atgatgcatc ttcagtaaag tatttatata cataaatgac aaaggaaaga aataatatat
     1561 atttttatgt ttgggggcaa tattttttag tgtgtaccta tctcgtggat gaatatgtac
     1621 aagtaaataa gaccacgatt ttaagtgtaa agtgcatgta agactttgtt tttgtaaatg
     1681 gttggataca tttcctgggt aacttaggct gggttgtcct aaagcagggg caggtaaatt
     1741 gacgccaaga agtacctaag gtcatgcatg tggtctgggc agtagcagca gcctgagctt
     1801 ctcctcacct gaaagcacgt tgtatcttaa tgtggtggaa aggcaggtgg gtgaatgact
     1861 tgttttcctc tctgaagaca tgttggaact agaactagag attttgaaaa gctagtagtt
     1921 agggtttatt atatatttgt atataaggga cactgtactt tacccaaagt cagaactgtt
     1981 ctaagaagaa agcaagctct taagatgtgt tcagtcacgt gagctgagtg gtgtcgtgtg
     2041 tgtgaagctg tgaggtgtgc agaggcttcg atgagcattc atggtcagct gcatctgtag
     2101 agcagatggc gctatggcat gctctcacag tggggcactt taccagagta cgtcctcgcc
     2161 ggctgtccga ccacagtggt atttggcctc agcagatggg cgttctcgct gctgtcggat
     2221 ggtgtgacag tgctgtccat gggtcagttc tgtaagtgct gaggtgctac tgctgtgcac
     2281 ccgggatgcc atttgctgta tgtaagcctt tagctcatgt ggttaagtac cttgactgaa
     2341 cgttgaaata aatattattt gtgcctccaa ccagggtcta aaagtcattc taaaacaaca
     2401 gatttgtcta gtcttgtgtc atggacttgc ctggtgtatg tatgtttagt gcactatcag
     2461 cttcacgacc cccagcccgt catgtaaatt gtttacagaa gtgatccagc aaaataacat
     2521 tgaacaggcg taaactaagc ttaggttatt tcctcccaca ctgagcacat gaccttcacc
     2581 attgcagttt ttagggttaa gcttctattg caatagggaa tttttcttta tttctttgtc
     2641 cttcttggac ataaatttga cctactagat taaaaccagt tatggtcaag ctggaggact
     2701 ttgtggataa aacatttctc cacaacctca gcctagatcc aggactcgtg ttgttgcagt
     2761 gcattgagcc aaaaccattt tgcttgtgtt gatgaaggaa actttgagaa taactatata
     2821 acaccaggca tggtggcatg aatttaaggg cagcctggcc tacatagctg catagacaac
     2881 cttctgaact tacccaagag tcgcgagtag cttgtagata cagtggctta cagagcctct
     2941 cacctacctt gtctcagaat ggactgagct ttgtctttgg ttttcttcca cattaaatac
     3001 taagatcatc agtttcaaaa tacagacgat agcctcagct ttttactgtg ttttactttt
     3061 tgcagaaatg gttggtttgg ggttttttgt ttgttttggg tctttttaaa aattaaaagt
     3121 agcctatatt cagttagaac atggagagct ggctcaacag ttgtaagaac acttccaagt
     3181 ttagttccca gcaccaatgg ccagcagcag ctcacggctg cctttaattc cagctccagg
     3241 ggatttgctt cagtctctgg cctctgggca tctgcataca catgcacaca tacacagaat
     3301 ctttttttaa aaatgaataa aattcacaag gaacagctta atataatata taccttcttg
     3361 cctagggagt ctgaaacaga attctaagtt ggggcctatc tgggctacat agcaagccct
     3421 tgactgaaga agaaggagaa cagtgcttta actgcacttg aatgaatgtg gtatagagat
     3481 gtgcccacag taaatgtaaa catacctgta cagctggtga taaatagtag gttagaggaa
     3541 aagccatatt aagttgatat ttaattggta caatataact ttttcccatg tcatatttta
     3601 attttcatga ttaactgaga tgaaaatgca tagagtaatt ctttgacttt ttttaattct
     3661 tttgactttt tttgcaggag tcttagctaa atttgacagg tttaattcag gtttaattca
     3721 ggtttttgtt accatctctg ttactttggc tctgactgcc ctctttttat caagtttttc
     3781 ttagaaaata atgtaactct gttctgcttg tgttcctgaa aaagcaccaa gggaagctgt
     3841 gaggtttcca cctcacattg aagcctttaa ccaggggcaa gaggggccag gaagtgtggt
     3901 gctaagcaga gttagaagat aagtgagaaa atgggccatt aaaaaggctt ggttatcacc
     3961 tacatgctct cttaaggaac gtactctgta tagctgccgg tggtttcatt tcccatttcc
     4021 atacagaaac agatgtaagg catggattga cgagggaact gctggtagcc ctgggatgat
     4081 actctcctgt cctttgcatc ttcaggcaga aacaggtctg aacaatggcg tagcagctac
     4141 agtctccatg tcaagaccaa tcccaccctt cacagttggt aacgttaatg ttggcttctg
     4201 tgctacctgt catgacttaa gtgtcaccag ctccttgaca gtattcttcc agagaacttg
     4261 tgtcatgttc ctgcagccat gtatgtgagt gctcagggaa cttgaagaga taatctcatg
     4321 aagtgtgctg ggaattagca ctgtgacaca tgtagcagag caggccagtt tcttgatgga
     4381 attggtaggt ctctatgaaa ggtgacagta gctttggcat tctttgtccc gtgttttaag
     4441 tagagaattg ttgctggaag atagtggtgc acactcttta tcccagcact ttggaggcag
     4501 aggcaggctg atctctgaat tctacagact gagttccaag acagccagag aaaccctgtc
     4561 tcaaaatgta gaaaaattgt taacactgtt agagacacag atagttgaca atagaggtag
     4621 tcaccccatt ctgctttggt tttgttctgc tgcctcccct ccctcccctc acccctgttt
     4681 tcctttggta ttttagacat tgatcagtca tatctcagag ggctggaata agaaaaatct
     4741 atacacaggt gaacacttgt actagtgaga gtttactttg tactagaaaa tgggaattgg
     4801 gtagtgggcc ttgctaagac catcaagaaa ctaggtttaa gctgtgttct aagctggtac
     4861 aaatgacctg tcagaggacc cctttacctt cagctcccct tctgagatcc taaattctga
     4921 attcagaatc aggatggcag aagacagtaa tggagctttt aagttcttaa tggtaattga
     4981 aacaaaacag gatgtgaaac agtaagaggt aactttaatt tgaatagggc agtttgttgc
     5041 tattatatat aatatgtaat ggtgtggaac caaatttaaa atactttgag aaattcacat
     5101 agaacatttt aggatcaagc accaggtgaa aaccaatcat tttaggacct accatggtca
     5161 tgtacatgtg attccaacac tggaggctaa ggcagaagga ttaggagttg ggggccagtc
     5221 tggattactt agcaagttca ggacaaccta agcgggtgta cagagtgaaa cctgccctgg
     5281 gtttgggggt ggggtggggt gggcgtgatg gtggagtaac acattgcatt aaaattagtt
     5341 ttaaaatgat aaaagctatt tcagataact gccttaaatt tcctacaata attaaaactt
     5401 ggaattcgaa gtttttgtgt atttgtatac tccatcctac cttcgtatat agacttccaa
     5461 aggttaatgt cctaacagcc gctacaatgt ttactcatga aaacccagct agtaaatatt
     5521 ggtgttcagg gctgccagct tgcccagtcc ttggggttct gttcacatag aacacaattc
     5581 ggagttgatc aaacactgtt gcactttgct tcatacttca aaacaacttt cattaggagc
     5641 tcacatgctg tcacttagac aaaattaact cactgtgacc tttttgctgt tcttacatag
     5701 tactgactct agtgttgtca tttcagtgag aattcagtct gtctgtcttc gggaaacggc
     5761 tctagttcta ggcagtgaga agcagctctt tagcatccgc aaagtgtgct attttctctt
     5821 cctttgactt gttcggaata cagtggtgtg tcctcatttg ttacacgtat taccataata
     5881 ttaatgcatc ttaataaatc agttggaata ta
//
LOCUS       NM_001436458            2891 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 49 (Lrrc49),
            transcript variant 1, mRNA.
ACCESSION   NM_001436458 XM_063265143
VERSION     NM_001436458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063265143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.33949.1,
                                           SRR26360172.2019935.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000008.1  70056247-70056481   c
            236-292             JAXUCZ010000008.1  70055581-70055637   c
            293-380             JAXUCZ010000008.1  70053406-70053493   c
            381-578             JAXUCZ010000008.1  70049009-70049206   c
            579-681             JAXUCZ010000008.1  70048576-70048678   c
            682-885             JAXUCZ010000008.1  70045578-70045781   c
            886-952             JAXUCZ010000008.1  70039865-70039931   c
            953-1096            JAXUCZ010000008.1  70037281-70037424   c
            1097-1158           JAXUCZ010000008.1  70019484-70019545   c
            1159-1306           JAXUCZ010000008.1  69996747-69996894   c
            1307-1390           JAXUCZ010000008.1  69984849-69984932   c
            1391-1554           JAXUCZ010000008.1  69980873-69981036   c
            1555-1792           JAXUCZ010000008.1  69965190-69965427   c
            1793-1978           JAXUCZ010000008.1  69963925-69964110   c
            1979-2088           JAXUCZ010000008.1  69959742-69959851   c
            2089-2242           JAXUCZ010000008.1  69954547-69954700   c
            2243-2891           JAXUCZ010000008.1  69948964-69949612   c
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2891
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
     exon            1..235
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="upstream in-frame stop codon"
     CDS             188..2446
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 49"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 49
                     isoform 1"
                     /protein_id="NP_001423387.1"
                     /db_xref="GeneID:300763"
                     /db_xref="RGD:1309466"
                     /translation="MIPGKYRSVSGRAANNVNCGLHLVIQTSSLSDKNKVEFKLNRET
                     PSFPGRLLQHDLERNYSSRQGDGRVISPSPRNKSSCISSTTNVTELCGLDMRTATTSL
                     SAFGDSSIQTPSKPRIRQGCHSAGPNVSGDHINLVSSSMPSFPILQRSSEEKTLYSDR
                     LTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGL
                     STLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARN
                     LLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAES
                     TSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVAKKEEEKKR
                     ESHKQSLLKEKKRLTINNVARKWDLQQRVANIAIIQDRKDSESPPQESCQIDGGTISA
                     FPEEAGSLDAGLSSALQGLSVTETHLVELDGETLSLYGSGALECLDRNWSVQTAGMVT
                     TVSFTFIEFDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDP
                     QGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQY
                     RMISILGDARKKQFRYLLENKCKKPGILCEETSDSKRLMGENTNRATLNYTTREFYHE
                     KLEEIKDKKKFCRLYVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSY
                     MKLCLQQITDQK"
     misc_feature    665..718
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    665..718
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..790
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..790
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    734..1321
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    734..1321
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    791..856
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    791..856
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    857..922
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    857..922
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    923..988
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    923..988
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    989..1054
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    989..1054
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1055..1120
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1055..1120
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1121..1195
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1121..1195
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            236..292
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            293..380
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            381..578
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            579..681
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            682..885
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            886..952
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1096
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1158
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1306
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1390
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1554
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1792
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1978
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2088
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2242
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2891
                     /gene="Lrrc49"
                     /gene_synonym="RGD1309466"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagataatc cctgaggcta gccacccgga cggcccacag atctggggcg aggaccagac
       61 cggaaatggt ggtttctatg gtaacccctg aacaggttgc ctgggagatg accccttttg
      121 gtctctttga atcttagctg ttgcattacc tcgaaggagg atcgaacatc ctggactgtt
      181 tcctgccatg attcccggga aataccgctc cgtttctggc cgggctgcaa acaacgtgaa
      241 ctgtggactt catctggtta ttcaaacgtc gtcactttct gacaaaaaca aagttgaatt
      301 caagcttaat agagaaacac catcatttcc tggtagactg ttacagcatg acctggagag
      361 aaactactca agtagacaag gagatggaag agtaataagt ccttcgcctc gtaataagtc
      421 atcatgcatc tcatccacaa ctaacgtgac agaactctgt gggctggaca tgagaactgc
      481 cacaacctcc ttgtcagcat ttggagactc ttccattcag acaccttcaa agcccagaat
      541 ccggcagggc tgtcatagtg ctggccccaa tgtatctggt gatcacatta atctggtgag
      601 ctcatcaatg ccatcatttc ctattctcca gcgttcttct gaagagaaaa ctctttactc
      661 agacaggctg accctagaaa gacaaaagtt gactgtgtgc cctatcatcg acggggagga
      721 gcaccttcgt ttgttgaact ttcagcacaa ttttataact cggatccaaa atatttctaa
      781 tctacagagg ctaatattct tggacttata tgataaccag attgaagaaa ttagtgggct
      841 ttccactctg aaatcccttc gtgtcctcct gttagggaag aacagaatca agaaaatctc
      901 aaatctggag aatctaaaaa atttagatgt cttggacctt catggaaatc agattaccaa
      961 aattgaaaat gttaatcatt tgtgtgactt gagagtttta aaccttgcca ggaacctctt
     1021 gagtcatgtt gacaatctca acggtctgga ttcactaaca gaacttaacc ttcgccacaa
     1081 ccagatcacc ttcgtgagag atgtggataa tttgccctgc ctccaacgcc tcttcctcag
     1141 cttcaacaat ataactagct ttgaaagtgt ttcctgcctt gctgagtcaa cttccctctc
     1201 agacatcacc tttgatggca atccaatagc tcaagagtca tggtacaaac acacggtcct
     1261 tcagaatatg atgcagctgc gccagctaga catgaagaga atcacggaag aagaaagacg
     1321 cgtggcatct gttgtggcca aaaaagagga ggagaagaag agggagagtc acaagcagtc
     1381 cttgctgaag gagaagaaaa ggttaacaat taacaacgtc gctcgaaagt gggacttgca
     1441 gcaacgagta gccaatatcg ccatcattca ggacagaaag gactctgagt ctcctcctca
     1501 ggaatcctgt cagatcgatg gaggcaccat ctccgcattt cccgaggaag cagggtctct
     1561 agatgcggga ctcagcagtg cgttacaagg cttgtctgtc acagaaacac acttggtgga
     1621 gctagatgga gaaaccctgt cactgtatgg ctcaggggcg ctggaatgcc tagatcgtaa
     1681 ctggagtgtt caaacagctg gcatggtcac caccgtctcg ttcacattca tcgagtttga
     1741 tgaaattgtc caagtacttc ccaaactgaa gatgaagttt ccaaattctc tgcaccttaa
     1801 gttcagggag accaaccttg tgatgctgca gcagttcaac gccctcgcgc aacttcgtcg
     1861 ggttgaccag ttgacaatcg atcctcaggg aaacccagtg gtgaacttca cactctggaa
     1921 gtactacgtg ctgtttaggc tcagccactt cagcatgcag aaaataaatg gaacagaggt
     1981 gacacaaaat gacatgataa tggctgaaag gctctttgga atcttagcac atgtggcatc
     2041 ctctgagctg ccccagtacc gcatgatttc aattctgggt gatgccagga aaaagcagtt
     2101 ccggtatctg ctggagaaca aatgtaaaaa gcctggcatc ctctgtgagg agacgagtga
     2161 cagcaagaga ttaatggggg aaaacacaaa ccgagctacc ctgaattaca ccacccgaga
     2221 attctaccac gagaagctgg aggaaataaa ggacaagaag aagttctgca ggttgtatgt
     2281 agaagacctg gtgaaggaag ccacagccat caacatgaaa aatgaggctc tgcagaagct
     2341 gtggccacag atgttcatcg agcttgtcag ggatgccgtc atagagatcc gcagcaagga
     2401 ctcctacatg aagctctgcc tgcagcagat cactgaccag aaatagggat ggctcatgct
     2461 tcagacatgg gcaattggag ctgttttaaa gttgggcaag atgcaggtta gacatgatga
     2521 gacatcacca cttccgcaca tactagaaag agcggcatca aagcctcgcc ccctgcactg
     2581 ttgaggagga gggaggcagg agagaggggg actctttccc acgcatgctg accacacaac
     2641 cttggggacc cgagcagcaa ctggagaagg cctggctgct gggtcagaaa tgcttcttca
     2701 gctcctgctc tgactggtgt gcctgccccc gtcccaggca cagtgcgtgc tgatgggcaa
     2761 gcatgagacg cctctaccaa cctccagctg agacttttct cttattttgc ctttttattt
     2821 tatgtcatga tttcaaagcc aagcttatgt tcttttttat gagtgaaaaa taaatacatt
     2881 agtaaaaaaa a
//
LOCUS       NM_001100942            1347 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus proteasome maturation protein (Pomp), mRNA.
ACCESSION   NM_001100942 XM_001060809 XM_213700
VERSION     NM_001100942.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Shin,S.W., Shimizu,N., Tokoro,M., Nishikawa,S., Hatanaka,Y.,
            Anzai,M., Hamazaki,J., Kishigami,S., Saeki,K., Hosoi,Y.,
            Iritani,A., Murata,S. and Matsumoto,K.
  TITLE     Mouse zygote-specific proteasome assembly chaperone important for
            maternal-to-zygotic transition
  JOURNAL   Biol Open 2 (2), 170-182 (2013)
   PUBMED   23429752
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Fricke,B., Heink,S., Steffen,J., Kloetzel,P.M. and Kruger,E.
  TITLE     The proteasome maturation protein POMP facilitates major steps of
            20S proteasome formation at the endoplasmic reticulum
  JOURNAL   EMBO Rep 8 (12), 1170-1175 (2007)
   PUBMED   17948026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_001100942.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161800.1, EV765329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000012.1  12210817-12210881   c
            66-163              JAXUCZ010000012.1  12208946-12209043   c
            164-224             JAXUCZ010000012.1  12204791-12204851   c
            225-326             JAXUCZ010000012.1  12204085-12204186   c
            327-420             JAXUCZ010000012.1  12200335-12200428   c
            421-1347            JAXUCZ010000012.1  12197492-12198418   c
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1347
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /note="proteasome maturation protein"
                     /db_xref="GeneID:288455"
                     /db_xref="RGD:1305831"
     exon            1..65
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    3..5
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /note="upstream in-frame stop codon"
     CDS             63..488
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /note="voltage-gated potassium channel beta subunit 4.1"
                     /codon_start=1
                     /product="proteasome maturation protein"
                     /protein_id="NP_001094412.1"
                     /db_xref="GeneID:288455"
                     /db_xref="RGD:1305831"
                     /translation="MNARGLGSQLKDSIPVTELSASGPFESHDLLRKGFSCVKNELLP
                     SHPLELSEKNFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLPSSNLSL
                     DILRGNDETIGFEDILNDPSQSELMGEPHMMVEYKLGLL"
     misc_feature    135..476
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /note="Proteasome maturation factor UMP1; Region: UMP1;
                     pfam05348"
                     /db_xref="CDD:461627"
     misc_feature    135..476
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /note="Proteasome maturation factor UMP1; Region: UMP1;
                     pfam05348"
                     /db_xref="CDD:461627"
     exon            66..163
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
     exon            164..224
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
     exon            225..326
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
     exon            327..420
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1347
                     /gene="Pomp"
                     /gene_synonym="RGD1305831"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgagcgcc ttggctggcc gactatagcg ggttcagagg gtttcgcaga gctgtttcca
       61 agatgaacgc cagaggcctt gggtcgcagc taaaggacag tattccagtt acagaactct
      121 cagccagtgg gcctttcgag agtcatgatc ttctccggaa agggttttct tgtgtgaaaa
      181 atgaactttt gcccagtcac cctcttgaat tatcagaaaa aaatttccag ctcaaccagg
      241 acaagatgaa cttttccacc ctgaggaaca tccagggcct gtttgctccc ctgaagttac
      301 agatggagtt caaggctgtg cagcaggttc agcgtcttcc gtttcttccg agctcaaacc
      361 tctcactgga tattttgagg ggcaacgacg agaccattgg ttttgaggat attcttaatg
      421 atccatcaca aagtgaactg atgggcgagc cacacatgat ggtggagtat aagctgggct
      481 tgctgtgacg cagggcgccg tgcaggaacc acggatgtgc ttctcgtagt tgcctctgcc
      541 gaggtctgat gttcacagca ttaaagtact gagaggatcg ctgggtcatg tggatgtgtt
      601 tggggcgtgg tttggggctg tgaaagccta gaggtggttt ctaagctctt aggttacaga
      661 aaagcccgac ttctgaaaat gtgtttctta taaatgctac aaatgcaaca acgttcccag
      721 gagcctcctt cagagtcacg gctgtgactg gatttggtgg cagcacccgg cacagcctta
      781 gctttgctct gcaggatgct acttgcacct taagggctct agccaagtgt tctcacaagt
      841 tgaaaagtcg gcgtttgcag agtttgatct tttctgcatg agaagttaga tgcagcagcc
      901 ggggtgtgca gcttggactg tggtgcttcg tgggtttacc tcacgcttca gcttatcaag
      961 cagtgttcta tggaaggaaa gtgcaggcca cttgctttta agttacatag caaggtacag
     1021 aaatgttttt aagttagaat attcctatta tatacccatg gataattcca tactactttt
     1081 ttataataca ttttcaacat aatggtcctt aaaatattgt taatagaact ggtctataaa
     1141 aactcaagtt tttcctgggt gtggtaatgc acacttcagt ctccacactg gagaggcagg
     1201 gcaggtagat atttgggatt ttcaggccag cttagtctac atagcgagtt ccagaccagc
     1261 cagaagtaca cagtgagacc ctgtcaaaaa caaagacctt aaggttttca gaacactagt
     1321 aaatggatca tttttttttt tactaga
//
LOCUS       NM_001436455            7333 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus tectorin alpha (Tecta), transcript variant 1,
            mRNA.
ACCESSION   NM_001436455 XM_039081047
VERSION     NM_001436455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7333)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 7333)
  AUTHORS   Mustapha,M., Weil,D., Chardenoux,S., Elias,S., El-Zir,E.,
            Beckmann,J.S., Loiselet,J. and Petit,C.
  TITLE     An alpha-tectorin gene defect causes a newly identified autosomal
            recessive form of sensorineural pre-lingual non-syndromic deafness,
            DFNB21
  JOURNAL   Hum Mol Genet 8 (3), 409-412 (1999)
   PUBMED   9949200
REFERENCE   3  (bases 1 to 7333)
  AUTHORS   Verhoeven,K., Van Laer,L., Kirschhofer,K., Legan,P.K., Hughes,D.C.,
            Schatteman,I., Verstreken,M., Van Hauwe,P., Coucke,P., Chen,A.,
            Smith,R.J., Somers,T., Offeciers,F.E., Van de Heyning,P.,
            Richardson,G.P., Wachtler,F., Kimberling,W.J., Willems,P.J.,
            Govaerts,P.J. and Van Camp,G.
  TITLE     Mutations in the human alpha-tectorin gene cause autosomal dominant
            non-syndromic hearing impairment
  JOURNAL   Nat Genet 19 (1), 60-62 (1998)
   PUBMED   9590290
  REMARK    Erratum:[Nat Genet 1999 Apr;21(4):449]
REFERENCE   4  (bases 1 to 7333)
  AUTHORS   Legan,P.K., Rau,A., Keen,J.N. and Richardson,G.P.
  TITLE     The mouse tectorins. Modular matrix proteins of the inner ear
            homologous to components of the sperm-egg adhesion system
  JOURNAL   J Biol Chem 272 (13), 8791-8801 (1997)
   PUBMED   9079715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_039081047.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000008.1  51676293-51676576   c
            285-349             JAXUCZ010000008.1  51675001-51675065   c
            350-483             JAXUCZ010000008.1  51671726-51671859   c
            484-771             JAXUCZ010000008.1  51668785-51669072   c
            772-909             JAXUCZ010000008.1  51664955-51665092   c
            910-1075            JAXUCZ010000008.1  51664494-51664659   c
            1076-1488           JAXUCZ010000008.1  51660814-51661226   c
            1489-2059           JAXUCZ010000008.1  51654605-51655175   c
            2060-2652           JAXUCZ010000008.1  51652140-51652732   c
            2653-3226           JAXUCZ010000008.1  51650301-51650874   c
            3227-3828           JAXUCZ010000008.1  51644582-51645183   c
            3829-4390           JAXUCZ010000008.1  51634598-51635159   c
            4391-4590           JAXUCZ010000008.1  51627235-51627434   c
            4591-4974           JAXUCZ010000008.1  51622884-51623267   c
            4975-5261           JAXUCZ010000008.1  51620631-51620917   c
            5262-5542           JAXUCZ010000008.1  51618858-51619138   c
            5543-5653           JAXUCZ010000008.1  51615231-51615341   c
            5654-5856           JAXUCZ010000008.1  51613989-51614191   c
            5857-6020           JAXUCZ010000008.1  51612896-51613059   c
            6021-6269           JAXUCZ010000008.1  51612169-51612417   c
            6270-6432           JAXUCZ010000008.1  51607786-51607948   c
            6433-6520           JAXUCZ010000008.1  51606670-51606757   c
            6521-6637           JAXUCZ010000008.1  51606290-51606406   c
            6638-7333           JAXUCZ010000008.1  51604974-51605669   c
FEATURES             Location/Qualifiers
     source          1..7333
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..7333
                     /gene="Tecta"
                     /note="tectorin alpha"
                     /db_xref="GeneID:300653"
                     /db_xref="RGD:1309824"
     exon            1..284
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="Tecta"
                     /note="upstream in-frame stop codon"
     exon            285..349
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..6738
                     /gene="Tecta"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha-tectorin"
                     /codon_start=1
                     /product="alpha-tectorin isoform 1 precursor"
                     /protein_id="NP_001423384.1"
                     /db_xref="GeneID:300653"
                     /db_xref="RGD:1309824"
                     /translation="MNYSSLLRIWVSFIFALVRHQAQPRELMYPFWQNDTRTPKVDDG
                     SSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWAD
                     VHNGIRGEIYYRETMDSAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSST
                     TPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTN
                     FFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDD
                     LNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFD
                     GFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVNGYKILI
                     PKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIP
                     GSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHTDWKCGSGCIDNCT
                     QCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQ
                     AIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQNCA
                     TPCTEGCECNEGFVLSTSQCVPLHKCGCDFEGHYYTMGEFFWATANCTVQCLCEEGGD
                     VYCFNKTCRSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLL
                     KTCPERPEYLEIDINKRKPDAGPAWLRGVRILVADQEVKIGGVGALEVKLNGQDVELP
                     FFHPSGRLEIHRNKNSTTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANA
                     SDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGI
                     INDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVG
                     PWRTYDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQC
                     VTRSECGCNFEGHQLATNETFWVDQDCQIFCYCNGTDNSVHCETIPCRDDDYCMEESG
                     LYYCQPRTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRSISDSFPKFIVTAK
                     NEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNNERLYLPLKLGQGKINIFSFG
                     FHVVVETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPGDDLEMPMGLLALS
                     INEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHSKVNP
                     TFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSCSVTCPPNSHY
                     ESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHNCGCYSDGKYYEP
                     KQLFWNGDCTRRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCFSTKTSYCLAAGGGV
                     FRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEE
                     QILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISI
                     SERLQNKVCGLCGNFNGDMTDDYVTLRGKPVVSSVVLAQSWKTNGMQKSCNELQFSQY
                     AATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNHKKFQLC
                     GSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELDNGGELCGCIEP
                     PPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSGIEGEDFIS
                     FQINNTKGNCGNVVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAYELDIK
                     ISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLYVGV
                     FVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGVSLTCR
                     FHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYSKEHKEQIISVGP
                     IRRKRLDWCEDNGGCEQVCTSRVDGPLCSCVTGSLQEDGRSCRASNSSVEPQVWTLLL
                     IMTQISLWHFVYQSGATS"
     sig_peptide     286..357
                     /gene="Tecta"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    577..1047
                     /gene="Tecta"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; Region: NIDO;
                     smart00539"
                     /db_xref="CDD:214712"
     misc_feature    577..1047
                     /gene="Tecta"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; Region: NIDO;
                     smart00539"
                     /db_xref="CDD:214712"
     misc_feature    1222..1716
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    1222..1716
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    1834..2058
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    1834..2058
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    2074..2235
                     /gene="Tecta"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     Region: TIL; pfam01826"
                     /db_xref="CDD:460351"
     misc_feature    2074..2235
                     /gene="Tecta"
                     /note="Trypsin Inhibitor like cysteine rich domain;
                     Region: TIL; pfam01826"
                     /db_xref="CDD:460351"
     misc_feature    order(2101..2103,2113..2115,2152..2154,2164..2166)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(2101..2103,2113..2115,2152..2154,2164..2166)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    2239..2403
                     /gene="Tecta"
                     /note="von Willebrand factor type C domain; Region: VWC;
                     cl17735"
                     /db_xref="CDD:450195"
     misc_feature    2239..2403
                     /gene="Tecta"
                     /note="von Willebrand factor type C domain; Region: VWC;
                     cl17735"
                     /db_xref="CDD:450195"
     misc_feature    2392..2880
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    2392..2880
                     /gene="Tecta"
                     /note="von Willebrand factor (vWF) type D domain; Region:
                     VWD; smart00216"
                     /db_xref="CDD:214566"
     misc_feature    2998..3228
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    2998..3228
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    3235..3393
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    3235..3393
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    order(3262..3264,3271..3273,3310..3312,3322..3324)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(3262..3264,3271..3273,3310..3312,3322..3324)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    3583..4059
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    3583..4059
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    4183..4389
                     /gene="Tecta"
                     /note="C8 domain; Region: C8; pfam08742"
                     /db_xref="CDD:462584"
     misc_feature    4183..4389
                     /gene="Tecta"
                     /note="C8 domain; Region: C8; pfam08742"
                     /db_xref="CDD:462584"
     misc_feature    4399..4560
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    4399..4560
                     /gene="Tecta"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     Region: TIL; cd19941"
                     /db_xref="CDD:410995"
     misc_feature    order(4426..4428,4438..4440,4477..4479,4489..4491)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    order(4426..4428,4438..4440,4477..4479,4489..4491)
                     /gene="Tecta"
                     /note="reactive site [polypeptide binding]; other site"
                     /db_xref="CDD:410995"
     misc_feature    4744..5202
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    4744..5202
                     /gene="Tecta"
                     /note="von Willebrand factor type D domain; Region: VWD;
                     pfam00094"
                     /db_xref="CDD:459671"
     misc_feature    5323..5541
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    5323..5541
                     /gene="Tecta"
                     /note="This domain contains 8 conserved cysteine residues;
                     Region: C8; smart00832"
                     /db_xref="CDD:214843"
     misc_feature    5683..6447
                     /gene="Tecta"
                     /note="Zona pellucida (ZP) domain; Region: ZP; smart00241"
                     /db_xref="CDD:214579"
     misc_feature    5683..6447
                     /gene="Tecta"
                     /note="Zona pellucida (ZP) domain; Region: ZP; smart00241"
                     /db_xref="CDD:214579"
     misc_feature    6535..6633
                     /gene="Tecta"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    6535..6633
                     /gene="Tecta"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     exon            350..483
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            484..771
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            772..909
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1075
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1488
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2059
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2652
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..3226
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3828
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4390
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4590
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4974
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5261
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5542
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5543..5653
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..5856
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            5857..6020
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6269
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6270..6432
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6433..6520
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6521..6637
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
     exon            6638..7333
                     /gene="Tecta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaaagag cctctccatg caatcctgaa accgatcttc agatttcctt ttccttaatc
       61 aatagaaagc aacttgattg caactcaaca ctcccccgac tctagtgcag gactaactga
      121 atttttggtt ttaagagtat gggattcgga cgtgattcca gggatcagaa ataattgaca
      181 gtcacgcaag gagaactgac gtgaattctt atacctaatt ttccgggctc accaagattt
      241 gagttaatac ttttcactca attcctccag tctcgactga acaggatgaa ttattcatca
      301 ttacttagaa tttgggtctc tttcatcttc gctcttgttc ggcaccaagc tcagcccagg
      361 gagctcatgt atccattttg gcagaatgac accagaaccc ctaaagtaga cgacggaagc
      421 tcatctgaga ttaagttggc catccctgtc ttcttctttg gtgttcctta ccgcactgtc
      481 tatgttaata acaacggtgt tgtttccttc aacgtgctag tgagccagtt tacgccagag
      541 tcctttcccc tgacggatgg gagggccttc attgctccgt tttgggcaga cgtgcacaac
      601 ggaattcggg gtgagatcta ttacagagaa accatggact ctgccatctt gagaagagcc
      661 accaaggaca tcaggaagta cttcaaagac atgaccacct tctctgccac ttgggttttc
      721 attgtgacct gggaggaagt cacgttttac ggaggcagca gtaccacacc tgtgaacacc
      781 ttccaggccg tgctggtgtc agatggctcc tacacgttca cactctttaa ttactatgag
      841 atcaactgga ctactgggac agccagtggt ggcgaccctc tgacaggcct cggaggtgtg
      901 atggcacagg caggatttaa tggtggaaac ctcacaaatt tcttcagtct tccggggtcg
      961 agaacccctg agattgtgaa tattcaagag accacaaatg tcaacgttcc aggacgctgg
     1021 gcttttaaag ttgacgggaa ggaaattgac ccggccaatg gctgcacctc tagaggacag
     1081 ttccttcgtc gaggggaggt gttttgggac gacctgaatt gtaccatcaa gtgccgctgt
     1141 ctggatttca acaatgagat ctactgtcag gaggcctcct gtagccccta cgaggtgtgc
     1201 gaacccaagg gccggttctt ctactgcagc ccagtggaga ccagtacctg tgtggtgttt
     1261 ggggaaccac actaccacac ctttgatggc ttcctcttcc acttccaagg ctcttgtgct
     1321 tacctgttgg cccgacagtg tctacaaacc tccagtctcc ccttcttcag tgtggaggcc
     1381 aagaatgagc accgaggagg ctctgctgtc tcatgggtga aggagctctc tgttgaggtg
     1441 aatggctaca agattctcat tcctaaagga agctatggga aagtcaaggt taatgaccta
     1501 gtgacttctt tgcccgtcac cttagagttg ggggcggtga aaatctacca gagtggcatg
     1561 tctactgccg tggaaacaga ttttgggctc ttagtgacgt ttgacggcca gcactacgcc
     1621 tccatttcca tcccaggctc ttacataaac tccacctgtg gactgtgtgg gaactacaac
     1681 aaaaacccac tggacgactt cctccgccca gatggcaggc ccgccatgtc cgtgctggac
     1741 ctcggagaga gttggcgtgt ctaccacact gactggaagt gtggctctgg ctgcatagac
     1801 aactgtactc agtgcgatgc ggccaccgag gccctctact ttggttctga ctactgcggc
     1861 tttctcaaca agacggacgg ccccctgtgg gagtgcggca ctgttgtgga tgccacggct
     1921 ttcgtgcaca gctgtgtgta cgatctgtgc agtgtgaggg acaacggcac gctcctctgc
     1981 caagccattc aggcctacgc cttggtgtgc caagccctgg gcatcccaat cggagactgg
     2041 agaatccaaa ctgggtgtgt gtctaccgtg cggtgcccca gcttcagcca ttactctgta
     2101 tgcaccagta gttgccctga cacctgctcg gacctgacgg cctctcagaa ttgcgccacg
     2161 ccgtgcacgg agggttgcga gtgcaacgag ggttttgtcc tcagtaccag ccagtgtgtc
     2221 ccattgcaca agtgcggctg tgacttcgag ggccactact ataccatggg ggagttcttc
     2281 tgggccacgg ccaattgcac agtgcagtgc ttatgtgaag agggcgggga tgtctactgc
     2341 ttcaacaaga cctgccgcag tggggaggtg tgtgcggtgg aggatggtta ccagggctgc
     2401 ttccccaagc gggagactgt gtgcctgctc agccagaacc aggtgctaca cacgtttgac
     2461 ggcgccgctt acgccttccc atctgagtta tcatacacac tactcaagac ctgccccgag
     2521 cgtcccgagt acttggagat tgacatcaac aagaggaagc ctgatgcagg gcctgcttgg
     2581 ctccggggtg ttcggatcct cgtggctgac caagaggtca agataggagg cgtcggggct
     2641 ttggaagtca agttaaatgg tcaagatgtg gaactaccct ttttccatcc ttcggggagg
     2701 ctggagattc atcgaaacaa aaacagcaca actgtggagt ccaagggtgt ggtgtctgtc
     2761 cagtactctg atgtgggact actctatatc cggctctcca ccatgtactt caactgtact
     2821 gggggcctgt gtggcttctt caacgccaat gccagcgatg agttctgcct tcctaatggc
     2881 aagtgcacag acaacctggc ggtgttcttg gagagttgga ccacgttcga ggaaatctgc
     2941 aacggcgagt gtggggacct gctgaaggcc tgcaacaatg actccgagct gctcaagttc
     3001 tatcggagcc gctcccggtg cggtatcatc aatgacccct ctaatagctc cttcctggag
     3061 tgtcatgggg tggtcaacgt cactgcctac taccgcacct gccttttccg cctatgccag
     3121 agcggaggca acgagtcaga gctgtgcgat tctgtggccc gctatgccag tgcttgcaag
     3181 aacgcagatg tggaggtggg cccctggagg acctatgact tctgccctct cgaatgcccg
     3241 gagaacagcc atttcgagga atgtatgaca tgtacagaga cctgtgagac cttggccttg
     3301 ggccccatct gtgtggatag ctgctctgag ggatgccagt gtgatgaagg ttatgcactg
     3361 cagggcagcc agtgtgtaac tcggagcgag tgcggctgca actttgaggg gcatcaactt
     3421 gccaccaatg agaccttctg ggtagaccag gactgccaga tcttctgcta ctgcaatggc
     3481 acagacaaca gtgtccactg tgagaccatt ccctgcaggg acgatgatta ctgtatggaa
     3541 gagagtggct tatactactg ccagccccgt actgatgctt cctgtatcgt ctccggctat
     3601 ggccactacc tcacttttga tggctaccct tttgacttcc agaccagttg ccctctcatt
     3661 ctctgcacca caggaagcag atcaatctca gactctttcc caaagttcat tgtcacagcc
     3721 aagaatgagg accgggaccc atctctagcc ttgtgggtga agcaggtgga tgtgaccgtg
     3781 tttggctaca gcattgtgat ccaccgggct tacaagcaca ctgtgctggt caacaatgaa
     3841 cggttgtacc tgcccctgaa gttaggacaa gggaagatca acatcttttc cttcggtttt
     3901 catgtggttg tggagacgga ctttggcctg aaggttgtgt atgactggaa aactttcctg
     3961 tctatcaccg tcccccggag catgcagaac agcacttacg gtctttgtgg gcgctacaat
     4021 ggtaaccctg gtgatgacct ggagatgccc atgggcttgc ttgcactgag tatcaatgag
     4081 tttggccaga gctgggtgaa gagggacacc ttctgccagg tgggctgtgg ggaccgctgc
     4141 ccatcgtgtg ccaaagttga aggtttctcc aaagtacagc agctgtgcag cctgatcccc
     4201 aaccagaacg ctgggtttgc caagtgtcac agcaaagtca accctacctt cttctacaaa
     4261 aactgcctct ttgactcctg catcgatggg ggtgcagtgc agacagcctg cagctggtta
     4321 cagaactatg ccagcacttg ccagacacaa ggagtcgcag tgaccggctg gaggaactac
     4381 acatcgtgct cggtcacctg cccccccaac agccactacg agagttgcgt gagcgtctgc
     4441 cagcctcgct gcgctgccat ccgcctgaag agtgactgca atcactactg cgtagagggc
     4501 tgccagtgcg acgcgggcta cgtcctcaac ggcaagagct gcatcttgcc ccacaactgt
     4561 ggctgctact cggacggcaa atactacgag cccaagcagc tattctggaa cggggactgc
     4621 acacggcgct gccgctgttt ccgacgcaac ctgatccagt gcgacccacg ccaatgcaag
     4681 tcagatgaag agtgcgccct gcgcagtggg gtgcgcggct gcttcagcac caagacctcc
     4741 tactgcctgg cggcaggggg cggtgtcttc cgcacgtttg atggcgcctt cctgcgcttc
     4801 cctgccaact gcgccttcgt gctctcgacc atctgccaga aactgccaga catctccttc
     4861 cagctcatca tcaacttcga caagtggtcc tcacccaacc tcactatcat ctcaccggtc
     4921 tatttctaca ttaatgaaga gcagattctc atcaatgacc ggaacactgt caaggtgaat
     4981 ggcacacaag taaatgttcc atttataact ggcttggcaa ccaaaatcta cagcagcgag
     5041 gggtttctgg tgatcgacac cagccctgac atccagatat actacaacgg tttcaacgtc
     5101 attaaaatca gcatcagtga gaggctgcag aacaaagtgt gcggcctctg tggcaacttc
     5161 aatggagaca tgactgatga ctacgtgacc ttgcggggga aacccgtggt gagcagtgtg
     5221 gtgctggccc agagctggaa gaccaatggc atgcagaaga gctgcaacga gctacagttc
     5281 tcgcaatacg cagccacgtg tgacaatgtg cacatccagg ccatgcaggg tgacggttac
     5341 tgcctgaagc tcaccgacat gaagggcttc tttcagccct gctatgggct cctggatccc
     5401 ctccccttct acgagtcctg ctacctggac ggctgctaca accacaagaa gttccagctg
     5461 tgcggctccc tggctgccta cggggaggcc tgccgttcct tcggcatcct tagcacggag
     5521 tggattgaga aagagaattg ctcaggagtg gttgaagacc cctgtgtggg ggcagactgt
     5581 cccaacagga cctgcgagct ggacaacgga ggagaattat gtggctgcat tgagccaccc
     5641 ccctatggaa acaattccca tgacatcatc gacgcagagg tgacctgcaa ggcagcccaa
     5701 atggaagtgt ccatatctaa atgcaagctc tttcagctgg gctttgagag agagggggtg
     5761 agaatcaatg acagacagtg ctctggcatc gagggagagg attttatctc ctttcagatc
     5821 aacaacacca aggggaactg tgggaacgtc gtgcagtcca atggtactca tatcatgtat
     5881 aaaaacacaa tctggatcga aagtgccaac aacacaggca acatcatcac gagggaccgc
     5941 accatcaatg tggaattttc atgcgcgtat gagctagata tcaagatctc cttggactct
     6001 gttgtgaagc ctatgctaag tgtcatcaac ctgacagttc caacccaaga gggcagcttc
     6061 accaccaaga tggcgctcta taaaaacgcg tcctacaaac acccttaccg ccagggggag
     6121 gtcgtgctga cgacccggga tgtgctctac gtgggggtct ttgtggttgg cgctgactcc
     6181 acacacttga ttctcacact caacaaatgc tacgccaccc cgtcccgcga cagcaacgac
     6241 aaactccggt acttcatcat cgaaggaggg tgtcagaaca tcaaggataa caccattggc
     6301 atcgaggaga acggagtgtc cctaacctgt cgtttccacg tcaccgtctt caaattcatc
     6361 ggagactacg atgaagttca tcttcactgt gcagtgtccc tctgtgactc agagaaatac
     6421 tcttgcaaga ttaattgccc acaaaattcc aggatcgcca cagattattc aaaagagcac
     6481 aaagaacaga tcatttcagt gggacccatt aggagaaaga ggctggattg gtgtgaagac
     6541 aatggcggct gtgagcaggt ctgcaccagc agggtcgacg ggcctctgtg cagttgcgtg
     6601 actggatccc tgcaagaaga cggacggagc tgcagagcct ctaattcttc agtggaacct
     6661 caagtgtgga cccttcttct catcatgacc cagatctccc tgtggcattt tgtctatcaa
     6721 tcaggcgcaa cctcataatg aactcagggt gcttccttca gtccctgtag gtataaaagt
     6781 gtgtgccccc aagtcaaaac aacctctcaa actcacgcca ccttcctcca gctgtcagat
     6841 ccggaggaca ccagcgttcc cggctcctct tccacaccat gcaatagtag cttctcaaag
     6901 ccaacaggag gaaagcacgc gtttacctga atgccgaagc tggcactggg aacctcggtg
     6961 caggccataa gccagtcagg gacagctctg ctctcagaag tctgatggga aatctggccg
     7021 gaaaagtcgg tctgtcccgt gctctttcag gatcgccgtg gttacagaca aggctgttgc
     7081 cgtgatttcc aataaagctg ccgttctctc tgcggagcct ctccggcact gcccttagcc
     7141 catgcttagc tccttccctc ctgctctggc ctccaccttg ccgtgccagc ttcggccact
     7201 ggagatgatg attgcagacc tggagaacct cacccagccc ttcctgaccc tcaaacccag
     7261 tccttcactt tttacaaatc aaccaaataa tttttaacgt gttttatcct taaataaact
     7321 ttgtgttcaa gta
//
LOCUS       NM_020078               2973 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 1a (Adam1a), mRNA.
ACCESSION   NM_020078 XM_346440
VERSION     NM_020078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2973)
  AUTHORS   Nishimura,H., Kim,E., Nakanishi,T. and Baba,T.
  TITLE     Possible function of the ADAM1a/ADAM2 Fertilin complex in the
            appearance of ADAM3 on the sperm surface
  JOURNAL   J Biol Chem 279 (33), 34957-34962 (2004)
   PUBMED   15194697
REFERENCE   2  (bases 1 to 2973)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   3  (bases 1 to 2973)
  AUTHORS   McLaughlin,E.A., Frayne,J., Barker,H.L., Jury,J.A., Jones,R.,
            Ford,W.C. and Hall,L.
  TITLE     Cloning and sequence analysis of rat fertilin alpha and
            beta--developmental expression, processing and immunolocalization
  JOURNAL   Mol Hum Reprod 3 (9), 801-809 (1997)
   PUBMED   9358007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced NM_020078.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: Y08616.1, BC081807.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2973              JAXUCZ010000012.1  40678016-40680988
FEATURES             Location/Qualifiers
     source          1..2973
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2973
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="ADAM metallopeptidase domain 1a"
                     /db_xref="GeneID:56777"
                     /db_xref="RGD:621467"
     exon            1..2973
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    339..341
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="upstream in-frame stop codon"
     CDS             345..2714
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 1; a disintegrin and metalloprotease domain 1
                     (fertilin alpha); ADAM 1; fertilin subunit alpha; a
                     disintegrin and metalloproteinase domain 1 (fertilin
                     alpha); PH-30 alpha; a disintegrin and metallopeptidase
                     domain 1a"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 1 precursor"
                     /protein_id="NP_064463.2"
                     /db_xref="GeneID:56777"
                     /db_xref="RGD:621467"
                     /translation="MSVAASASRSASTLCSPQIQQGALKEAKVPPHIWAARHWNLGLR
                     LVPGHASVRAGILVLLIFLPSTLCDLGSVYDSSYETVIPERLPGQGSDDPGGKVSYVL
                     LMQGQKQLLHLEVKGHYSERNFPVYSYHHGILGQEVPLLSQACHYEGHIEGVPGSFVS
                     VSICSGLRGVLIKEETAYGIEPLLFSTDFEHILYTMAHQPVVLCNVTPTDSLGDSSQR
                     QGSSKTDELLALSDLWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIALANSFT
                     RGINTEVVLVGLEIWTEGDPIEVPVDLQATLRNFNLWRQEKLMGRVRHDVAHLIVGHR
                     PGANEGQAFLDGACSGGFAAAVEAFHHEDVLLFAALMAHELGHNLGIRHDRPGCTCGP
                     KHLCLMHETISKTSSFSNCSSDHFLRFLHDHRGACLLDRPWHQSHKRRDAHCGNGVVE
                     ESEECDCGNACDSHPCCEPTCTLKVGAQCSEGLCCYKCTFKKKGTLCRPAEDVCDLPE
                     YCNGITGECPANSYMQDGTQCDRIYYCSGGLCKNPDKQCARIYGYPARSAPEECYISV
                     NTKANRFGNCGHPTSANLKYEACSNEDIFCGKLVCTDVRYLPQVKPLHSLLQIPYGDD
                     WCWSMDAYNVTDIPDYGDVQGGTYCAPKKVCMESICTGHATLQYDCHPQEMCHGNGVC
                     NNFKHCHCDAGFSPPDCSSGGNGGSVDSGPVGKPADRNLSLFGVGESPDSRMEDEEIN
                     LKVVVLVVPIFLIVLLCCLMLIAYLWSEVQEAVSPGSSSTTSSSESESD"
     sig_peptide     345..548
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70505.1)"
     misc_feature    579..926
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    579..926
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    1056..1640
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1056..1640
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1119..1121
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70505.1); glycosylation site"
     misc_feature    1572..1574
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70505.1); glycosylation site"
     misc_feature    1692..1910
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Homologues of snake disintegrins; Region: DISIN;
                     smart00050"
                     /db_xref="CDD:214490"
     misc_feature    1692..1910
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="Homologues of snake disintegrins; Region: DISIN;
                     smart00050"
                     /db_xref="CDD:214490"
     misc_feature    1914..2324
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1914..2324
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    2241..2243
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70505.1); glycosylation site"
     misc_feature    2502..2504
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70505.1); glycosylation site"
     misc_feature    2571..2633
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="propagated from UniProtKB/Swiss-Prot (P70505.1);
                     transmembrane region"
ORIGIN      
        1 gagtctgaaa gcatgagcag gttagcgtgt caaggggtgt ccatcatgac ctgtggagga
       61 tgagcgatgt tctgacgtac agcaccagcg agtcacgtag acacagggct cgtctccatg
      121 agcgtcaaag gaacttaagc cacactggag ctcttccact tgacaaaagt ccctgtgctg
      181 cacataacca acgaggccag gagaaaaata agaccagaga taccgcctga ggccagagga
      241 ttcacgcagg ggagcacccc ttaagggaca ggcttgggtc tgggaaagca gtgagttgcc
      301 actgatggac atagatccta cgctatccac agtttgtttg aaccatgtca gtggcagcat
      361 cagcgagcag gagtgcgtcc acgctgtgtt ctccacagat ccagcaagga gccttaaaag
      421 aagctaaggt gccccctcac atctgggctg cacggcattg gaacctgggt ctacgactag
      481 tgccaggaca cgcatctgtt agagcaggga tcttggtgct actgattttt ctcccgagca
      541 cgctctgtga cctaggatct gtatatgact cttcctatga gacggtcatc cccgagagac
      601 tgccaggcca ggggagtgac gatcctggag ggaaggtgtc ctacgtgctg ttgatgcaag
      661 gccaaaagca gctgcttcac ctcgaggtaa agggacacta ctctgagagg aacttcccgg
      721 tctacagcta ccaccatggt atcctggggc aagaagtgcc cctcctctcc caggcctgcc
      781 actatgaagg ccacatagaa ggggtgccag gctcctttgt ttctgtcagc atctgttcag
      841 gcctcagggg ggtcttgatc aaagaggaaa cagcctatgg catcgagccc ctgctctttt
      901 ccacagactt tgagcacatc ctctatacca tggcgcacca gcctgtggtc ctctgcaatg
      961 tcactcctac agacagcctg ggggactcca gccagcgaca agggagcagc aagaccgatg
     1021 agctgctggc tctgtctgac ttgtggtcac acgccaagta tgtggagatg tttgtcgtgg
     1081 tcaaccacca gcgcttccag atgtggggca gtgatgtcaa cacgacggtc caggcggtag
     1141 tggacatcat tgctctggcc aacagcttca ctaggggaat aaacacagag gtggtgctgg
     1201 tgggcctgga gatctggaca gagggggacc cgatagaggt cccagtggac ctgcaggcta
     1261 cactgaggaa tttcaacttg tggagacagg agaaactcat gggccgggtc aggcacgatg
     1321 tggcacactt gatcgtcggg catcgcccag gagcgaacga gggccaggcg tttctcgatg
     1381 gtgcctgttc aggcgggttt gcggcggccg tggaggcctt ccatcatgag gatgtcctcc
     1441 tgtttgcggc gctcatggcc cacgagcttg ggcacaacct gggtatccgg cacgaccgcc
     1501 caggctgcac ctgtggtcct aagcacctct gcctcatgca tgagacgatc agtaagacca
     1561 gtagcttcag caactgcagc tctgaccact tcctccgttt cctccatgac cacagagggg
     1621 cctgcctgct tgaccggcct tggcaccaga gccacaagcg cagagatgcc cattgtggaa
     1681 atggtgtggt agaggagtcg gaggagtgtg actgtggtaa tgcctgtgac agtcacccat
     1741 gctgtgagcc aacatgtaca ctgaaggtgg gtgcgcagtg cagtgaggga ctctgctgct
     1801 acaaatgtac attcaagaag aaagggacct tatgtcgtcc tgctgaggat gtatgtgacc
     1861 ttcccgagta ctgcaatggc attactggag aatgccctgc aaacagctac atgcaggacg
     1921 gcacgcagtg cgataggatt tattactgct ctgggggttt gtgtaagaac cctgataagc
     1981 aatgtgcaag gatctatggg tatcctgcaa gatcggcccc cgaggagtgt tacatttcag
     2041 ttaatactaa agccaaccgg tttggaaact gtggccatcc cacctcggct aacctaaaat
     2101 atgaagcatg ttccaatgag gatatatttt gtgggaagtt ggtatgcacg gatgttagat
     2161 acttgcccca agtcaagccc ctacactcac tcctccagat tccttacgga gatgactggt
     2221 gttggagcat ggatgcctat aacgtcactg acatccctga ttacggtgac gtgcagggcg
     2281 gtacctactg tgccccaaaa aaagtctgca tggagtccat ctgcaccggt catgccacgc
     2341 tccagtatga ctgtcatcca caggaaatgt gtcatgggaa tggagtgtgc aacaacttca
     2401 aacactgtca ctgtgatgct ggcttctccc ctcctgactg cagcagtgga ggaaatgggg
     2461 ggagtgtgga cagtggtcct gtcgggaagc cagctgaccg aaacttgagt ctttttggag
     2521 ttggggagag tccggattcg aggatggagg atgaggagat caacctcaaa gtggtggtgc
     2581 ttgtggtccc catcttcctt attgtcctgc tgtgctgtct aatgctcatc gcctacctct
     2641 ggtctgaagt acaagaggca gtgtctccag ggtcttcaag cacaacctca tcctcagagt
     2701 ccgagtccga ctgacgtccg cagacctcct cgtgggctgt tgctaccgag gccgtgtgtt
     2761 tgcggggcag tttttcctcc gtggttttta gggcttgttg catgcacact gtttactgta
     2821 atgtgttgta tatacacttg tgttgctctt ctctaccgta acaactggta ttatcgtgtg
     2881 aaagttttta tgggatctaa atgttctaac ttgccctgtc agctactgtt cataaaatac
     2941 aagtcatttt aaataaacat gaataacaag gcc
//
LOCUS       NM_001271133            3109 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus piwi-like RNA-mediated gene silencing 4 (Piwil4),
            transcript variant 2, mRNA.
ACCESSION   NM_001271133 XM_001072752
VERSION     NM_001271133.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3109)
  AUTHORS   Henaoui,I.S., Jacovetti,C., Guerra Mollet,I., Guay,C., Sobel,J.,
            Eliasson,L. and Regazzi,R.
  TITLE     PIWI-interacting RNAs as novel regulators of pancreatic beta cell
            function
  JOURNAL   Diabetologia 60 (10), 1977-1986 (2017)
   PUBMED   28711973
REFERENCE   2  (bases 1 to 3109)
  AUTHORS   Sivagurunathan,S., Palanisamy,K., Arunachalam,J.P. and
            Chidambaram,S.
  TITLE     Possible role of HIWI2 in modulating tight junction proteins in
            retinal pigment epithelial cells through Akt signaling pathway
  JOURNAL   Mol Cell Biochem 427 (1-2), 145-156 (2017)
   PUBMED   28025795
REFERENCE   3  (bases 1 to 3109)
  AUTHORS   Yang,Z., Chen,K.M., Pandey,R.R., Homolka,D., Reuter,M.,
            Janeiro,B.K., Sachidanandam,R., Fauvarque,M.O., McCarthy,A.A. and
            Pillai,R.S.
  TITLE     PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
            Cytosolic Targets of the Mouse piRNA Pathway
  JOURNAL   Mol Cell 61 (1), 138-152 (2016)
   PUBMED   26669262
REFERENCE   4  (bases 1 to 3109)
  AUTHORS   Pastor,W.A., Stroud,H., Nee,K., Liu,W., Pezic,D., Manakov,S.,
            Lee,S.A., Moissiard,G., Zamudio,N., Bourc'his,D., Aravin,A.A.,
            Clark,A.T. and Jacobsen,S.E.
  TITLE     MORC1 represses transposable elements in the mouse male germline
  JOURNAL   Nat Commun 5, 5795 (2014)
   PUBMED   25503965
  REMARK    Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604.
            PMID: 26159654]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3109)
  AUTHORS   Keam,S.P., Young,P.E., McCorkindale,A.L., Dang,T.H., Clancy,J.L.,
            Humphreys,D.T., Preiss,T., Hutvagner,G., Martin,D.I., Cropley,J.E.
            and Suter,C.M.
  TITLE     The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in
            somatic cells
  JOURNAL   Nucleic Acids Res 42 (14), 8984-8995 (2014)
   PUBMED   25038252
REFERENCE   6  (bases 1 to 3109)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   7  (bases 1 to 3109)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   8  (bases 1 to 3109)
  AUTHORS   Aravin,A.A., Sachidanandam,R., Bourc'his,D., Schaefer,C., Pezic,D.,
            Toth,K.F., Bestor,T. and Hannon,G.J.
  TITLE     A piRNA pathway primed by individual transposons is linked to de
            novo DNA methylation in mice
  JOURNAL   Mol Cell 31 (6), 785-799 (2008)
   PUBMED   18922463
REFERENCE   9  (bases 1 to 3109)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Totoki,Y., Toyoda,A.,
            Ikawa,M., Asada,N., Kojima,K., Yamaguchi,Y., Ijiri,T.W., Hata,K.,
            Li,E., Matsuda,Y., Kimura,T., Okabe,M., Sakaki,Y., Sasaki,H. and
            Nakano,T.
  TITLE     DNA methylation of retrotransposon genes is regulated by Piwi
            family members MILI and MIWI2 in murine fetal testes
  JOURNAL   Genes Dev 22 (7), 908-917 (2008)
   PUBMED   18381894
REFERENCE   10 (bases 1 to 3109)
  AUTHORS   Carmell,M.A., Girard,A., van de Kant,H.J., Bourc'his,D.,
            Bestor,T.H., de Rooij,D.G. and Hannon,G.J.
  TITLE     MIWI2 is essential for spermatogenesis and repression of
            transposons in the mouse male germline
  JOURNAL   Dev Cell 12 (4), 503-514 (2007)
   PUBMED   17395546
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 1, 2012 this sequence version replaced XM_001072752.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000008.1  19861118-19861220   c
            104-235             JAXUCZ010000008.1  19857313-19857444   c
            236-450             JAXUCZ010000008.1  19854407-19854621   c
            451-572             JAXUCZ010000008.1  19849931-19850052   c
            573-653             JAXUCZ010000008.1  19848140-19848220   c
            654-851             JAXUCZ010000008.1  19844447-19844644   c
            852-963             JAXUCZ010000008.1  19842929-19843040   c
            964-1087            JAXUCZ010000008.1  19835733-19835856   c
            1088-1205           JAXUCZ010000008.1  19833845-19833962   c
            1206-1317           JAXUCZ010000008.1  19831229-19831340   c
            1318-1502           JAXUCZ010000008.1  19829442-19829626   c
            1503-1575           JAXUCZ010000008.1  19826182-19826254   c
            1576-1776           JAXUCZ010000008.1  19824687-19824887   c
            1777-1880           JAXUCZ010000008.1  19823626-19823729   c
            1881-1951           JAXUCZ010000008.1  19823388-19823458   c
            1952-2105           JAXUCZ010000008.1  19822130-19822283   c
            2106-2234           JAXUCZ010000008.1  19819948-19820076   c
            2235-2382           JAXUCZ010000008.1  19819279-19819426   c
            2383-3109           JAXUCZ010000008.1  19817986-19818712   c
FEATURES             Location/Qualifiers
     source          1..3109
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..3109
                     /gene="Piwil4"
                     /note="piwi-like RNA-mediated gene silencing 4"
                     /db_xref="GeneID:689972"
                     /db_xref="RGD:1311015"
     CDS             1..2499
                     /gene="Piwil4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     piwi-like protein 4; piwi-like 4"
                     /codon_start=1
                     /product="piwi-like protein 4 isoform 2"
                     /protein_id="NP_001258062.1"
                     /db_xref="GeneID:689972"
                     /db_xref="RGD:1311015"
                     /translation="MSGRARVRARGITTGHSAREVERAPRDLMVSASVYELGVSSGDG
                     RRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQL
                     YQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQR
                     GETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYK
                     LSLWPGFAISVSRFESKLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQL
                     VGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPV
                     LVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQ
                     LARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSK
                     DMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKVDENP
                     AAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGM
                     MLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAVVGFVASINSR
                     ITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAV
                     LEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEA
                     TRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVIS
                     VPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL"
     misc_feature    745..1095
                     /gene="Piwil4"
                     /note="PAZ domain, Piwi_like subfamily. In multi-cellular
                     organisms, the Piwi protein appears to be essential for
                     the maintenance of germline stem cells. In the Drosophila
                     male germline, Piwi was shown to be involved in the
                     silencing of retrotransposons in the...; Region:
                     PAZ_piwi_like; cd02845"
                     /db_xref="CDD:239211"
     misc_feature    745..1095
                     /gene="Piwil4"
                     /note="PAZ domain, Piwi_like subfamily. In multi-cellular
                     organisms, the Piwi protein appears to be essential for
                     the maintenance of germline stem cells. In the Drosophila
                     male germline, Piwi was shown to be involved in the
                     silencing of retrotransposons in the...; Region:
                     PAZ_piwi_like; cd02845"
                     /db_xref="CDD:239211"
     misc_feature    order(880..882,919..921,943..945,955..957,1009..1011,
                     1054..1056,1060..1062)
                     /gene="Piwil4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239211"
     misc_feature    order(880..882,919..921,943..945,955..957,1009..1011,
                     1054..1056,1060..1062)
                     /gene="Piwil4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239211"
     misc_feature    1117..2445
                     /gene="Piwil4"
                     /note="PIWI domain, Piwi-like subfamily found in
                     eukaryotes. This domain is found in Piwi and closely
                     related proteins, where it is believed to perform a
                     crucial role in germline cells, via RNA silencing. RNA
                     silencing refers to a group of related...; Region:
                     Piwi_piwi-like_Euk; cd04658"
                     /db_xref="CDD:240016"
     misc_feature    1117..2445
                     /gene="Piwil4"
                     /note="PIWI domain, Piwi-like subfamily found in
                     eukaryotes. This domain is found in Piwi and closely
                     related proteins, where it is believed to perform a
                     crucial role in germline cells, via RNA silencing. RNA
                     silencing refers to a group of related...; Region:
                     Piwi_piwi-like_Euk; cd04658"
                     /db_xref="CDD:240016"
     misc_feature    order(1612..1614,1624..1626,1660..1671,1678..1680,
                     1708..1710,1717..1719,1729..1731,1741..1743)
                     /gene="Piwil4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240016"
     misc_feature    order(1612..1614,1624..1626,1660..1671,1678..1680,
                     1708..1710,1717..1719,1729..1731,1741..1743)
                     /gene="Piwil4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240016"
     misc_feature    order(1804..1806,1810..1812,2014..2016,2419..2421)
                     /gene="Piwil4"
                     /note="active site"
                     /db_xref="CDD:240016"
     misc_feature    order(1804..1806,1810..1812,2014..2016,2419..2421)
                     /gene="Piwil4"
                     /note="active site"
                     /db_xref="CDD:240016"
     exon            1..103
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            104..235
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            236..450
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            451..572
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            573..653
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            654..851
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..963
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1087
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1205
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1317
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1502
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1575
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1776
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1880
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1951
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2105
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2234
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2382
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..3109
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtggac gggcccgtgt gagggcgcga ggcatcacca ctggccacag tgccagggaa
       61 gtggagcggg ccccaagaga cctcatggtg agtgcttctg tctatgagct tggcgtctct
      121 tctggtgatg gtagacgtac tctcgtggaa aaaagaggca atggcagaca ggacttcgtc
      181 gatttgggtg tctgtaccag ggagaagttg actcacgtaa aagattctaa aacaggttct
      241 agcggaatac ctgtgcagct ggctacaaat ctcttccatt tagatttgcc ccaggattgg
      301 cagctatacc agtaccatgt cacatacagc ccggatttag cctctaggag gctgaggact
      361 gctctgctgt ataaccacag catactctcc gacaaggcaa aggcattcga cggcaccagc
      421 cttttcctct cagaaaagct ggaccacaaa gtcacagaac tgacaagtga aacccaaaga
      481 ggggagactg tgaagataac tctcaccctg accagtgagc tgttcccaaa ctccccgatg
      541 tgcattcagt ttttcaatgt catcttcaga aagatcttta aaaagttgag catgtaccag
      601 attggacgga actactataa gccttcagag ccagtggaga tcccccagta caaattgtcc
      661 ctgtggcctg ggtttgccat ttctgtgtct cgctttgaaa gcaaactcct gttcaatgct
      721 gacgtaaact ataaagtcct ccgcaatgag actgttctgg aattcatgac tgatctctgc
      781 ctcagaaccg acatgtcatg cttcactgag acgtgccaca aacagctagt ggggctcatt
      841 gtccttacca ggtacaacaa caaaacatat cgtatcgatg acattgactg gtctgtgaag
      901 cccacacatg cctttcagaa gcgggatggc tcagagacca cgtatgtgga ttactacaag
      961 cagcaatatg atatcacctt atctgaccta aatcagccag tgcttgtcag tctgttgaaa
     1021 agaaggagaa atgataactc cgagcctcag atggtccacc tgatcccgga gctctgcttt
     1081 ctcacgggcc tgaccagcca agcaacctca gacttccgct tgatgaaggc agtcgctgaa
     1141 gaaactcggc tcagtcctat gggaaggcag cagcaactag cccgactggc agatgacatc
     1201 cagagaaacc aagtgactcg gtttgagctt gagacctggg gattgcattt tggaagccag
     1261 ctatccctga ccggccgggt tgttccctct gaaaagatcc tgctgcagga ccacacatgt
     1321 caacctgcat ttgctgctga ttggtccaaa gatatgcgat cttgcaaggt tctgagttct
     1381 gagcctttga atacatggtt gatcgtgtgc tgtagcaggg ctgagcattt gattgaatcc
     1441 ttcctgagct gtctgaggag agttggaggt tccacgggat tcagtgtggg ccacccaaaa
     1501 atcataaaag tggatgaaaa ccctgcagcg ttccttcgag ccatccagct gcacgtcaac
     1561 cccgatgttc agttggtgat gtgcatcctg ccttctaatc agaagaacta ttacgactcc
     1621 attaaaagat atttgagctc cgactgcccg gtcccaagcc agtgtgtgct gacccggacc
     1681 ttgaacaaac agggaatgat gctgagtgtg gccaccaaga tcgccatgca aatgacctgc
     1741 aaactcgggg gcgagctgtg ggctgtggag atcccattga agtcactgat ggtcgtgggc
     1801 atcgacatct gtagagacgc cctcagcaag gatgtagcgg tcgtcgggtt tgtcgccagc
     1861 attaactcca ggatcaccag gtggttttcc cgctgtgtcc tccagagaac ggcagctgat
     1921 attgcagatt gcctgaaagt ctgcatgact ggtgctctca acaagtggta caaacacaac
     1981 cacgatttgc cggcacggat aatcgcgtac cgggatggtg tgggcaacgg ccagctaaag
     2041 gcagttttgg aatacgaagt cccacagctg ctgagcagtg tgacagaatg tggctccgac
     2101 gccaggagct gtagactgtc agtggtcgtg gtcaggaaga ggtgtctgct gcgtctcttt
     2161 gccgagtctg gccatacgct acagaacccc ccacttggca ctgtcgtgga ctcagaagca
     2221 acacgtccag agtggtatga cttctacctg accagccaga ctgctaaccg ggggactgtt
     2281 agtcccacct actacaatgt catctatgac gacaacgctc tgaagcctga ccatatgcag
     2341 cggctgacct tcaaactgtg ccacctctac tacaactggc agggcgtaat cagtgtccct
     2401 gctccgtgcc agtatgcaca caagctgacc ttcctggtgg cacaaagcat ccacaaggaa
     2461 ccaagtctgg aattagccaa taagctcttc tacctgtgac aagtgggcca atagcatggc
     2521 tcgatggaga cgccaaaaag cggttgctat gctttgttca aatctgccta atgctcaagg
     2581 ctcctgctgc ttaaaggagc ttcagcctga ttttaagtat tgggaaggag agggtttttt
     2641 ggtttttgtt tttttgtttt gttttgtttt gttttttgtt ttctgggttt tttttttgtt
     2701 gttgttgttg ttgtttttaa agtcatctga atcagttgag gacaaaccta tggggatttt
     2761 tgtctcccct gtgtctaaaa acaacaatga caaacaaaca aaaacccaca gagtgatggg
     2821 ttttcttgtg gctctgtcag gcgacatttt actttgtcct ggtttatcct cgtatttttt
     2881 tttttttaag taaatgcttg aggtgaattc tcacatggta tatacgtgat gatattggga
     2941 tatatcatca cagctaactg gattctaaaa caatattcgt gtggtattgt gatggtgttt
     3001 aagaggggtt taacttcttt cctgacatta ccagggttgt tctaagtatc gtagagcatt
     3061 ttgtagagtg ggttaagtaa atactgaaaa taaagactcc ctgagcatc
//
LOCUS       NM_134340               2116 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus CDC-like kinase 3 (Clk3), transcript variant 2,
            mRNA.
ACCESSION   NM_134340
VERSION     NM_134340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Ma,X., Gao,L., Ge,R., Yuan,T., Lin,B. and Zhen,L.
  TITLE     CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 333-342 (2024)
   PUBMED   38438604
  REMARK    GeneRIF: CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway.
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2116)
  AUTHORS   Duncan,P.I., Stojdl,D.F., Marius,R.M., Scheit,K.H. and Bell,J.C.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   6  (bases 1 to 2116)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
REFERENCE   7  (bases 1 to 2116)
  AUTHORS   Becker,W., Kentrup,H., Heukelbach,J. and Joost,H.G.
  TITLE     cDNA cloning and characterization of rat Clk3, a LAMMER kinase
            predominately expressed in testis
  JOURNAL   Biochim Biophys Acta 1312 (1), 63-67 (1996)
   PUBMED   8679717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced NM_134340.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X94351.1, SRR26360172.2973633.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               JAXUCZ010000008.1  67061602-67062009   c
            409-560             JAXUCZ010000008.1  67058757-67058908   c
            561-777             JAXUCZ010000008.1  67057799-67058015   c
            778-874             JAXUCZ010000008.1  67055507-67055603   c
            875-941             JAXUCZ010000008.1  67055164-67055230   c
            942-1058            JAXUCZ010000008.1  67052689-67052805   c
            1059-1225           JAXUCZ010000008.1  67051925-67052091   c
            1226-1320           JAXUCZ010000008.1  67050871-67050965   c
            1321-1450           JAXUCZ010000008.1  67050644-67050773   c
            1451-1533           JAXUCZ010000008.1  67050006-67050088   c
            1534-1613           JAXUCZ010000008.1  67049514-67049593   c
            1614-1704           JAXUCZ010000008.1  67049175-67049265   c
            1705-2116           JAXUCZ010000008.1  67048121-67048532   c
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2116
                     /gene="Clk3"
                     /note="CDC-like kinase 3"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
     exon            1..408
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    400..402
                     /gene="Clk3"
                     /note="upstream in-frame stop codon"
     CDS             409..1881
                     /gene="Clk3"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3"
                     /protein_id="NP_599167.2"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR"
     misc_feature    409..822
                     /gene="Clk3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63117.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    427..429
                     /gene="Clk3"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    433..435
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    553..555
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    559..561
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    607..609
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    634..636
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    640..642
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    811..813
                     /gene="Clk3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49761; propagated from
                     UniProtKB/Swiss-Prot (Q63117.2); phosphorylation site"
     misc_feature    832..1824
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    832..1824
                     /gene="Clk3"
                     /note="Catalytic domain of the Dual-specificity protein
                     kinase, CDC-like kinase 3; Region: PKc_CLK3; cd14214"
                     /db_xref="CDD:271116"
     misc_feature    order(892..906,916..918,958..960,964..966,1006..1008,
                     1066..1068,1114..1125,1132..1134,1138..1143,1255..1257,
                     1261..1263,1267..1272,1276..1278,1366..1368,1375..1377,
                     1402..1404,1408..1419,1423..1425,1534..1536)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(892..906,916..918,958..960,964..966,1006..1008,
                     1066..1068,1114..1125,1132..1134,1138..1143,1255..1257,
                     1261..1263,1267..1272,1276..1278,1366..1368,1375..1377,
                     1402..1404,1408..1419,1423..1425,1534..1536)
                     /gene="Clk3"
                     /note="active site"
                     /db_xref="CDD:271116"
     misc_feature    order(892..903,916..918,958..960,964..966,1066..1068,
                     1114..1125,1132..1134,1141..1143,1267..1272,1276..1278,
                     1363..1368)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(892..903,916..918,958..960,964..966,1066..1068,
                     1114..1125,1132..1134,1141..1143,1267..1272,1276..1278,
                     1363..1368)
                     /gene="Clk3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(1006..1008,1138..1140,1255..1257,1261..1263,
                     1375..1377,1402..1404,1408..1419,1423..1425,1534..1536)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    order(1006..1008,1138..1140,1255..1257,1261..1263,
                     1375..1377,1402..1404,1408..1419,1423..1425,1534..1536)
                     /gene="Clk3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271116"
     misc_feature    1363..1425
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     misc_feature    1363..1425
                     /gene="Clk3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271116"
     exon            409..560
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..777
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..874
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..941
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1058
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1225
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1320
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1450
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1533
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1613
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1704
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2116
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagctccag ctgcctcgga gccggctggg aggatccact ttgggctccg agccggccct
       61 caggctgggg tcgtgtccga tctaagctat cctggaaaag gctttcccta tcccgagctc
      121 gaggcatagc ccgcagacct ccttcgcgcg ccgcctggag tttgattctg gcccaggctg
      181 gccatccctt tggtcgccgg gtcttccctt ggcggttacg gggaacggga ctctaagatc
      241 cctgggttcc gggaggaagg aagggacttg agtgcgggcc accggccccc tcggtgtttt
      301 gttatgatgg gaccgcttca ttccggagaa tgggccacac taagccagga gtacaaatgt
      361 ccaggctgct cctcggtccg gtcgggagcc tctatgcttt agttccggat gcatcactgt
      421 aagcgatacc gttccccaga gccagaccca tacctgagct accgctggaa gaggaggcgg
      481 tcttacagtc gggagcatga aggtcgacta cgatacccat cccgaaggga gcctccccca
      541 cggagatcaa ggtccagaag ccatgatcgt ataccctacc agaggaggta ccgggaacac
      601 cgagacagcg atacatatcg gtgtgaagag cggagcccat cctttggaga ggactgctat
      661 gggtcttcac gttctcgaca tcggagacgg tcacgagaga gggggccgta ccgtacccgc
      721 aagcatgccc accactgtca caaacgtcgt accaggtctt gtagcagcgc ctcctcgaga
      781 agccaacaga gcagtaagcg cagcagccgg agtgtggaag atgacaagga gggccacctg
      841 gtgtgccgga tcggcgattg gctccaagag cgatatgaga tcgtggggaa cctgggtgaa
      901 ggcacctttg gcaaggtggt ggagtgcttg gaccatgcca gagggaagtc acaggttgcc
      961 ctgaagatca tccgtaatgt gggcaagtac cgggaagctg ctcgtctaga aattaatgtt
     1021 ctcaagaaaa tcaaggagaa agacaaagaa aataagttcc tttgtgtcct gatgtctgac
     1081 tggttcaact tccatggtca tatgtgtatc gcctttgagc tcctgggcaa gaacaccttt
     1141 gagttcctga aggagaacaa cttccagcct tatcccctac cacatgtccg gcacatggcc
     1201 taccagctct gtcatgccct tagatttcta catgagaacc agctgaccca cacagacttg
     1261 aagccagaga acatcttgtt tgtgaattct gagtttgaaa ccctctacaa tgagcacaag
     1321 agctgcgagg agaagtcagt gaagaacacc agcatccgag tggcagactt tggcagtgcc
     1381 acatttgacc atgaacatca caccaccatt gtcgccaccc ggcattaccg cccacctgag
     1441 gtgatccttg agctgggctg ggcacagccc tgtgatgtct ggagtatcgg ctgcattctc
     1501 tttgagtact accgtggctt tacactcttc cagacccatg aaaacagaga acacttggtt
     1561 atgatggaga agatcctagg acccatccca tcacacatga tccaccgtac caggaagcag
     1621 aagtatttct acaaaggggg cctggtttgg gatgagaaca gctctgacgg gcggtatgtg
     1681 aaggagaact gcaaacctct gaagagttac atgctccagg actccctgga gcatgtgcag
     1741 ctgtttgacc tgatgaggag gatgttagag ttcgaccctg ctcagcgcat cacactggca
     1801 gaagctttgc tgcacccctt ctttgctggc ctgacccctg aggagcggtc cttccacagc
     1861 agccgtaacc ccagcagatg acaggtgcag gccagcacac gaagagttgg agagctggac
     1921 tgggctgctg gccccttttc tccagcctct cctactggct tcagagccag agccaccgat
     1981 gaacagtgca atgtgaagga aggcaggaac ctgcaaggga ttgggggtgt ggtgcccagc
     2041 tgccagaaag cacagattgg acccaagcta tttatatgtt gtaaagttat aataaagtgt
     2101 ttcttactgt ttgtaa
//
LOCUS       NM_001436420            3537 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, gamma (Ywhag), transcript
            variant 1, mRNA.
ACCESSION   NM_001436420 XM_006249184
VERSION     NM_001436420.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Han,L., Tang,J., Zhu,S. and Zhu,J.
  TITLE     LncRNA SNHG7 Knockdown Aggravates Hepatic Ischemia-Reperfusion
            Injury and Promotes Apoptosis in Hemorrhagic Shock Pregnant Rats by
            Modulating miR-34a-5p/YWHAG Axis
  JOURNAL   Mol Biotechnol 65 (6), 983-996 (2023)
   PUBMED   36427097
  REMARK    GeneRIF: LncRNA SNHG7 Knockdown Aggravates Hepatic
            Ischemia-Reperfusion Injury and Promotes Apoptosis in Hemorrhagic
            Shock Pregnant Rats by Modulating miR-34a-5p/YWHAG Axis.
REFERENCE   2  (bases 1 to 3537)
  AUTHORS   Abu-Rumeileh,S., Baiardi,S., Polischi,B., Mammana,A.,
            Franceschini,A., Green,A., Capellari,S. and Parchi,P.
  TITLE     Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob
            disease in the era of RT-QuIC
  JOURNAL   J Neurol 266 (12), 3136-3143 (2019)
   PUBMED   31541342
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   Otsuka,S., Sakakima,H., Terashi,T., Takada,S., Nakanishi,K. and
            Kikuchi,K.
  TITLE     Preconditioning exercise reduces brain damage and neuronal
            apoptosis through enhanced endogenous 14-3-3gamma after focal brain
            ischemia in rats
  JOURNAL   Brain Struct Funct 224 (2), 727-738 (2019)
   PUBMED   30478609
  REMARK    GeneRIF: Our findings suggest that preconditioning exercise prior
            to ischemia induces neuron- and astrocyte-mediated brain ischemic
            tolerance through increased expression of HIF-1alpha and
            14-3-3gamma, which are intrinsic protective factors; the
            upregulated 14-3-3gamma induced by preconditioning exercise reduces
            ischemic neuronal cell death through the 14-3-3gamma/p-beta-catenin
            Ser37/Bax/caspase 3 anti-apoptotic pathway.
            Erratum:[Brain Struct Funct. 2019 Mar;224(2):739-740. doi:
            10.1007/s00429-018-1815-x. PMID: 30560373]
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Kanata,E., Golanska,E., Villar-Pique,A., Karsanidou,A., Dafou,D.,
            Xanthopoulos,K., Schmitz,M., Ferrer,I., Karch,A., Sikorska,B.,
            Liberski,P.P., Sklaviadis,T., Zerr,I. and Llorens,F.
  TITLE     Cerebrospinal fluid neurofilament light in suspected sporadic
            Creutzfeldt-Jakob disease
  JOURNAL   J Clin Neurosci 60, 124-127 (2019)
   PUBMED   30309804
REFERENCE   5  (bases 1 to 3537)
  AUTHORS   Gerber,K.J., Squires,K.E. and Hepler,J.R.
  TITLE     14-3-3gamma binds regulator of G protein signaling 14 (RGS14) at
            distinct sites to inhibit the RGS14:Galphai-AlF4- signaling complex
            and RGS14 nuclear localization
  JOURNAL   J Biol Chem 293 (38), 14616-14631 (2018)
   PUBMED   30093406
  REMARK    GeneRIF: phosphorylation-independent binding of 14-3-3 has no
            effect on RGS14/Galphai interactions but, instead, inhibits
            (directly or indirectly) RGS14 nuclear import and nucleocytoplasmic
            shuttling
            Erratum:[J Biol Chem. 2019 Aug 9;294(32):12262. doi:
            10.1074/jbc.AAC119.101131. PMID: 31399537]
REFERENCE   6  (bases 1 to 3537)
  AUTHORS   Peyrl,A., Weitzdoerfer,R., Gulesserian,T., Fountoulakis,M. and
            Lubec,G.
  TITLE     Aberrant expression of signaling-related proteins 14-3-3 gamma and
            RACK1 in fetal Down syndrome brain (trisomy 21)
  JOURNAL   Electrophoresis 23 (1), 152-157 (2002)
   PUBMED   11824616
REFERENCE   7  (bases 1 to 3537)
  AUTHORS   Autieri,M.V. and Carbone,C.J.
  TITLE     14-3-3Gamma interacts with and is phosphorylated by multiple
            protein kinase C isoforms in PDGF-stimulated human vascular smooth
            muscle cells
  JOURNAL   DNA Cell Biol 18 (7), 555-564 (1999)
   PUBMED   10433554
REFERENCE   8  (bases 1 to 3537)
  AUTHORS   Martin,H., Rostas,J., Patel,Y. and Aitken,A.
  TITLE     Subcellular localisation of 14-3-3 isoforms in rat brain using
            specific antibodies
  JOURNAL   J Neurochem 63 (6), 2259-2265 (1994)
   PUBMED   7964746
REFERENCE   9  (bases 1 to 3537)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
REFERENCE   10 (bases 1 to 3537)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y. and
            Kondo,H.
  TITLE     Molecular cloning of rat cDNAs for beta and gamma subtypes of
            14-3-3 protein and developmental changes in expression of their
            mRNAs in the nervous system
  JOURNAL   Brain Res Mol Brain Res 17 (1-2), 135-146 (1993)
   PUBMED   8381897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006249184.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17447.1, SRR26360181.315695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000012.1  26381174-26381450
            278-3537            JAXUCZ010000012.1  26406233-26409492
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3537
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, gamma"
                     /db_xref="GeneID:56010"
                     /db_xref="RGD:62002"
     exon            1..277
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..934
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="tyrosine 3/tryptophan 5 -monooxygenase activation
                     protein, gamma polypeptide; tyrosine
                     3-monooxgenase/tryptophan 5-monooxgenase activation
                     protein, gamma polypeptide; 14-3-3 protein gamma-subtype;
                     tryosine 3-monooxgenase/tryptophan 5-monooxgenase
                     activation protein gamma polypeptide;
                     3-monooxygenase/tryptophan 5-monooxgenase activation
                     protein gamma polypeptide; tryosine
                     3-monooxgenase/tryptophan 5 monooxgenase activation
                     protein gamma; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, gamma polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein gamma"
                     /protein_id="NP_001423349.1"
                     /db_xref="GeneID:56010"
                     /db_xref="RGD:62002"
                     /translation="MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNL
                     LSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLS
                     LLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEI
                     SKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDDDGGEGNN"
     misc_feature    191..193
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); acetylation site"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="14-3-3 gamma, an isoform of 14-3-3 protein; Region:
                     14-3-3_gamma; cd10024"
                     /db_xref="CDD:206760"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="14-3-3 gamma, an isoform of 14-3-3 protein; Region:
                     14-3-3_gamma; cd10024"
                     /db_xref="CDD:206760"
     misc_feature    194..931
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="propagated from UniProtKB/Swiss-Prot (P61983.2);
                     Region: Interaction with SPATA18/MIEAP.
                     /evidence=ECO:0000250|UniProtKB:P61981"
     misc_feature    194..196
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="N-acetylvaline, in 14-3-3 protein gamma,
                     N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); acetylation site"
     misc_feature    order(206..208,215..220,227..232,236..241,245..247,
                     254..256,365..367,374..379,386..388,419..424,431..436,
                     443..445,452..457,464..466)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:206760"
     misc_feature    order(206..208,215..220,227..232,236..241,245..247,
                     254..256,365..367,374..379,386..388,419..424,431..436,
                     443..445,452..457,464..466)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:206760"
     misc_feature    order(338..340,359..361,563..565,584..589,719..724,
                     731..733,854..856,863..865,875..877,884..889)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206760"
     misc_feature    order(338..340,359..361,563..565,584..589,719..724,
                     731..733,854..856,863..865,875..877,884..889)
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206760"
     misc_feature    359..361
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250|UniProtKB:P61981;
                     propagated from UniProtKB/Swiss-Prot (P61983.2); other
                     site"
     misc_feature    401..403
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    584..586
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250|UniProtKB:P61981;
                     propagated from UniProtKB/Swiss-Prot (P61983.2); other
                     site"
     misc_feature    587..589
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    623..625
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    833..835
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    890..892
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     misc_feature    893..895
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P61981; propagated from
                     UniProtKB/Swiss-Prot (P61983.2); phosphorylation site"
     exon            278..3537
                     /gene="Ywhag"
                     /gene_synonym="14-3-3G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcctcct tgcgccgggt cccgcggtcg cagctcgtgc cgcctccttc tcgtcctcgc
       61 cttagcagct tgcttcgtgg gtcggtcctt ccgacacacg agctccaagc cgctcctctc
      121 ttttcctaaa gcccttcaag gcagtcttcg gtttccttct ttccagccga ccctcttcag
      181 ccccgcgaag atggtggacc gcgagcaact agtgcagaaa gcccggctgg ccgagcaggc
      241 ggagcgctac gacgatatgg ccgcggccat gaagaacgtg acagagctga atgaaccact
      301 gtccaacgag gaacggaacc tcctgtcggt ggcctacaag aacgtggttg gggctcgccg
      361 ctcctcctgg agggtcatca gcagcatcga gcagaagacg tctgcggatg gcaacgagaa
      421 gaagatagag atggtccgag cctaccggga aaagattgag aaggagctgg aggccgtgtg
      481 ccaggacgtg ctgagcctgc tggacaacta cctgatcaag aactgcagcg agacccagta
      541 cgagagcaag gtgttctacc tgaagatgaa aggggactat taccgctacc tggccgaagt
      601 ggccactggg gagaaaaggg cgaccgtggt ggagtcgtcc gagaaggcct acagcgaagc
      661 ccacgagatc agcaaggagc acatgcagcc cacccacccc atccggctgg gcctggcgct
      721 caactactcc gttttctact acgagatcca gaacgcccca gagcaagcct gccacctggc
      781 caagaccgcc ttcgatgacg ccatcgccga gctcgacact ctgaacgagg actcctacaa
      841 ggactccact ctgatcatgc agctgctccg agacaaccta acgctctgga cgagcgacca
      901 gcaagacgac gacggcggcg aaggcaacaa ctaaggcccc aggtggactg gcagcgcacg
      961 ctgatgctac tactgcagtc tttatttttt cccatgagtt gggggtcggg tgggggaggg
     1021 aaagggaggg ctgaccttcc cagggagaaa cccacgactg tcctgtcttt gattgcctct
     1081 ttgacatttt tgccaaaata ccactagtgg aaagtcaggc tagctatgct ggtatcggag
     1141 tagcagcctc acaggcgccg ggactgttgt gcaggtcgtg caagtggagc tgtctgcctt
     1201 tagtttaact tattgctaga cggtagggtt ctaagcagaa agaccggatg gatggccctc
     1261 tcgttcagtg cgttctgtgg ttccagtaag gattcttctg tccacacgcc ctcgtcttca
     1321 gttccgtggc tgttttctct ctgtggctct gctgttttct ttttctcttt tctcctttct
     1381 ttccccgggg tgtataccag agaagttaga gtctaaatta cccaagtgga caggcttaga
     1441 gtggaaggca caacctttat tgacgagtca gacgtggccc tgtacttaga agtctctgat
     1501 gggttgacag tattaacact aaattgtagt ttacagtatt tctacacgac agccatacat
     1561 gacaccaagc cattggttct gagttttcct ttgtcagtcg gctttacgtc tgtgtccagg
     1621 tcggtctggc tgtccatcag ctctcgtcat ggggagagtc agcttcccgg aggttttggt
     1681 tgatgggcgc ttggcaggtg gctgttgggg aatacttttt ttttttttct tctcggttct
     1741 tctttactct ctaaggcaag cccatcacaa aaatagaaac cgttaagtac cacacacaca
     1801 cagagaaaac agagaaaatt caggtctgta tgtcattatc agagactcct gctctcagca
     1861 gccagggctc catcctcagt gtcactgccg cttgaatgtt tctctgcact tgagtctgcc
     1921 cgtaccccgt gctagcagca cgcaggtatc taggtgtcgg gctagattgc agaggtggga
     1981 ggttaacgag acttggaaca tccggtgcca gcagctgagc caacaggaaa ccactgggaa
     2041 gaggcagttc tggtcctaaa ccagttgtcc ctgccacccc tccaaccccc agcactcctt
     2101 ccccaagtgc tcagtggagg gtaccgaggt tcagcaggag gcgctgctca cccctgtctg
     2161 acctaagctt tcctggtttt cctttctgaa tgaaatcgta gttgatggag attggcttct
     2221 cacgagatca ctgcacacgt gacattgaag gaagctgtgc tgctatgccc tacatggtcc
     2281 gtctcagccc ttggtccctc attctcactg tggataaatc ttcccataaa cgtgccctgt
     2341 tgcatgcaga gtgtgcagtt tgtctcctgg agaacccatg ctctcatggc ttcccaagat
     2401 ggcagcaccc tagacttgct ttacttgtct tcagaggccc agcagccact ttatcttata
     2461 ctgaaaccaa gctcccactt aagttgagta cgcttaacag gatgctggtg acgtggctgt
     2521 agaagaatga cgcccctctg cacagtccta gcatgccctc cctcagaggc ccctcctcat
     2581 gctggtgtgc aaacacccac taaccgaggc ccacggaaga ccgcagcgga ggaagcttgg
     2641 ccaccagagc catggacaga ggggttgggc ttcacccggt tggtttgtct ccatgtcggc
     2701 agtgagcatg tctgtcccgc ttgtactgtt tggaaatgac ctactggaat tgcaaaacct
     2761 agtttctctt taaatttcag ccttgacctt tgctgtgttc tagaaaagtc atgtgagggt
     2821 agaactgaag agggagagcg ggagacctga cgtgagcgtg gatggttcct tctccttccc
     2881 ttactgttga gaagcgcacc tgcctctgat gctgtctccg ttgccgcggt tgccccacct
     2941 attgatacag tattgtgcat gctggtgttg tatttctata cggtagctga catttattac
     3001 cttacactgt aggcgttatg tattcctatg acaacaaaac ttaagacttc aaaatctttt
     3061 taaacttttt ttttttaatt taattttttc ctttcagggg taaagtttgc tttaccaaaa
     3121 atagtggttg taacaaattg atctgttttg gatgttgcta tagtgacatg cagttctcta
     3181 ttttgttttc ggggggaggg gacaaaagaa acaccagtgt tagcttactc ttaatgtctg
     3241 gtgtttgtca tggtgaaatt ataactatta cagtgttgga gaacgccgcg gacgttctct
     3301 gaacgcacct ctgtgctttc ttgtcatgtt atgcagtgaa actattttta aggtctaatc
     3361 aagtgatttt ttccccccca actccgtgtt tcgctaagga attatttcgc acacggacca
     3421 ttcttagcag tttcctcagt gatggaatat tcatgaatgt gagtcattat gtagccgtcg
     3481 tacattgagc aaaataaact tacagatctg atgtcggtgc tgcctagctt catttaa
//
LOCUS       NM_001436451             867 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 3-like 1
            (Mbd3l1), transcript variant 1, mRNA.
ACCESSION   NM_001436451 XM_006242571
VERSION     NM_001436451.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006242571.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.15260.1,
                                           SRR26360181.3002426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000008.1  24432245-24432377
            134-867             JAXUCZ010000008.1  24435954-24436687
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..867
                     /gene="Mbd3l1"
                     /note="methyl-CpG binding domain protein 3-like 1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
     exon            1..133
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..867
                     /gene="Mbd3l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    137..139
                     /gene="Mbd3l1"
                     /note="upstream in-frame stop codon"
     CDS             152..712
                     /gene="Mbd3l1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3-like 1"
                     /protein_id="NP_001423380.1"
                     /db_xref="GeneID:300389"
                     /db_xref="RGD:1308259"
                     /translation="MGKTSQRKQCDCENPSKPCLSTSIPLRMSNYTFKRPVTKITSHL
                     GNEVRYYQWEETLEKPEQACWQKRLQGLQAYSSAGEILSTSDLSKALKDLTPRDTDAA
                     SSIIQANSMDPRPLSTLGSSSHLAKMIPEAGPQILCKEFLVTEEDISIQERKVKIARE
                     RLAVALIAHKLANETEKVRGSRKAKV"
     misc_feature    176..373
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    176..373
                     /gene="Mbd3l1"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; Region: MBDa; pfam16564"
                     /db_xref="CDD:465179"
     misc_feature    383..649
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
     misc_feature    383..649
                     /gene="Mbd3l1"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; Region: MBD_C; pfam14048"
                     /db_xref="CDD:464072"
ORIGIN      
        1 gacaacatat gaaggttcta aatcatccag agagctggtt agaggtaaga ggtaagatgt
       61 tacagagaaa tgtaatacag agctggttgg aggtaagatg ttacagagaa atgtaataca
      121 gagctggttg gagggctaag aacggagtca gatgggcaag acttcacaga ggaagcaatg
      181 tgactgtgag aatccatcaa agccttgttt aagtacctca atccccctga ggatgtctaa
      241 ttatacattc aagaggccag tcactaaaat cacatcccat ctgggcaatg aggtaagata
      301 ctatcagtgg gaggagacct tggagaagcc ggagcaagcc tgctggcaaa agagacttca
      361 aggactccag gcctacagca gtgcgggaga aattttgagc acttcagacc tttccaaggc
      421 tttgaaagat cttacaccta gagacacaga cgccgcctct tcaatcattc aagctaacag
      481 catggacccc aggcccttgt ccacccttgg gtcatcttca catttggcaa agatgatacc
      541 agaagcaggc ccacagatcc tttgcaaaga atttctggtc actgaagagg atattagcat
      601 ccaggaaagg aaagtgaaaa tagcaagaga aagactggca gtggcattga ttgcacacaa
      661 gctagcaaat gagacagaga aagtgagggg ttcaaggaaa gcaaaggtat aaacatgatg
      721 gggggaggga gtactgggga aaagacactg cacgtgaaat ggggcatagc cttgttttaa
      781 cgcctctttg cagtctttag ttgttttgag accttgaaac tttaaactta acaatacttt
      841 attaaaagtc tgtgcgatgc aaaaaaa
//
LOCUS       NM_001398706            2596 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus KRI1 homolog (Kri1), transcript variant 2, mRNA.
ACCESSION   NM_001398706 XM_039082791
VERSION     NM_001398706.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 22, 2021 this sequence version replaced XM_039082791.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1211164.1,
                                           SRR26360176.2094334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000008.1  28107448-28107557   c
            111-184             JAXUCZ010000008.1  28107283-28107356   c
            185-290             JAXUCZ010000008.1  28106181-28106286   c
            291-405             JAXUCZ010000008.1  28105041-28105155   c
            406-460             JAXUCZ010000008.1  28101867-28101921   c
            461-510             JAXUCZ010000008.1  28101743-28101792   c
            511-607             JAXUCZ010000008.1  28101532-28101628   c
            608-685             JAXUCZ010000008.1  28101378-28101455   c
            686-804             JAXUCZ010000008.1  28100749-28100867   c
            805-931             JAXUCZ010000008.1  28100380-28100506   c
            932-1027            JAXUCZ010000008.1  28100181-28100276   c
            1028-1198           JAXUCZ010000008.1  28099260-28099430   c
            1199-1274           JAXUCZ010000008.1  28096315-28096390   c
            1275-1363           JAXUCZ010000008.1  28096140-28096228   c
            1364-1490           JAXUCZ010000008.1  28095812-28095938   c
            1491-1621           JAXUCZ010000008.1  28095596-28095726   c
            1622-1686           JAXUCZ010000008.1  28095192-28095256   c
            1687-1785           JAXUCZ010000008.1  28095025-28095123   c
            1786-2596           JAXUCZ010000008.1  28093175-28093985   c
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2596
                     /gene="Kri1"
                     /note="KRI1 homolog"
                     /db_xref="GeneID:687183"
                     /db_xref="RGD:1588903"
     exon            1..110
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2113
                     /gene="Kri1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="protein KRI1 homolog isoform 2"
                     /protein_id="NP_001385635.1"
                     /db_xref="GeneID:687183"
                     /db_xref="RGD:1588903"
                     /translation="MPEPRAPATLKVNAAFAARYSRYREREELQRLKDRYGDRDDGSD
                     SSSESDSSDEHVEFDPQQERDFYRTLSLLKKKDPRIYQKDATFYQRTAEASSSESEEE
                     SAALGKQKKVQPMYLKDYERKVILEKEGKYVDEDNSDGESVDHRLQETATKSYIEEQR
                     QLKESFRAFVEDSSDEDSAGEGGSGLLQKHTKSGEEKAQEDVDYLEWLKGQKEIDSSE
                     SLKELTHLKEYWNNPELDEGEQFLRDYILNKRYEEDEEEETEEERVLGPPVQLAVDDS
                     SDEGELFLKKQEDFEHKYNFRFEEPDSASVKTYPRSIASSVRRKDDRRKEKREETRER
                     KKREKAKKQEELKQLKNLKRKEILAKLEKLRQVTGNETLGLEEQDLEDDFDPAQHDQL
                     MQKCFGDAFYGTVEEEKPQFEEEEGLEDDWNWDTWGGPEQNGAWSQQELHCEDPDFNM
                     DADYDPSQPRKKLREAPTSGKRKRKSPFAAAVGQEKPMFDPGDKTFEEYLDEYYRLDY
                     EDIIDDLPCRFKYRTVVPCDFGLSTEEILSADDKELNRWCSLKKTCMYRSEQEEMQEQ
                     RAYSQKAQSVWKKRQIFKSLCQEEVEMPTEATGKSPSKASSQVQLPMPSAAGGKKPQA
                     ELSGAKEEELAHTPCPEKPASQKQKSKKARLLGPTVTLGGHKFSRQRLQAFGLNPKRL
                     HFRQLGRQRKKQQSHA"
     misc_feature    968..1297
                     /gene="Kri1"
                     /note="KRI1-like family; Region: Kri1; pfam05178"
                     /db_xref="CDD:461569"
     misc_feature    968..1297
                     /gene="Kri1"
                     /note="KRI1-like family; Region: Kri1; pfam05178"
                     /db_xref="CDD:461569"
     misc_feature    1496..1762
                     /gene="Kri1"
                     /note="KRI1-like family C-terminal; Region: Kri1_C;
                     pfam12936"
                     /db_xref="CDD:463756"
     misc_feature    1496..1762
                     /gene="Kri1"
                     /note="KRI1-like family C-terminal; Region: Kri1_C;
                     pfam12936"
                     /db_xref="CDD:463756"
     exon            111..184
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..290
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..405
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..460
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..510
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..607
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..685
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..804
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..931
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1027
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1198
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1274
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1363
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1490
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1621
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1686
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1785
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2596
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtctcaca gccgccatgc cggaaccgcg cgctcctgcg actctaaagg tgaacgcagc
       61 ttttgctgca cgctacagcc gttaccgcga gcgtgaggaa ctacagcggc tgaaagatcg
      121 ctacggagat cgggacgacg gcagcgactc cagttccgag tctgactcca gcgatgagca
      181 tgtggaattt gatccccagc aggagagaga cttttataga actctgtcct tgttgaagaa
      241 gaaagaccct cgaatttacc agaaagatgc taccttctat cagagaacag cagaagcctc
      301 ctcttcagag agtgaggagg agtcagcagc cttgggaaag cagaagaaag tacagcccat
      361 gtacctgaag gactatgaga ggaaggtcat cttggagaaa gaaggcaaat atgtggacga
      421 ggacaactct gatggggaga gcgttgatca caggctccag gaaacagcca caaagagtta
      481 catagaagag cagagacagc tgaaggaaag cttccgtgcc tttgtggagg acagcagcga
      541 tgaggacagt gccggggaag gtggctctgg gctgctgcag aagcacacta agagtgggga
      601 agaaaaggcc caggaggatg tggactacct ggagtggcta aaggggcaaa aggagatcga
      661 cagctctgag tcgctgaaag aactgacaca cctcaaggag tactggaaca acccagaact
      721 ggacgagggg gagcagttcc tgagggatta tatcctcaac aaacgctatg aagaggacga
      781 ggaggaggag acagaggagg aaagggttct gggcccccca gtgcagctgg cggtggacga
      841 ctcctcagat gaaggggagc tattcctgaa gaagcaggaa gactttgaac acaagtacaa
      901 cttccgcttt gaggagcctg actcagcctc agtcaagaca tacccgcgga gcatcgcgtc
      961 gtctgtgcgt cgcaaggacg accgcaggaa ggagaagagg gaggagacca gggagcggaa
     1021 gaagagggag aaagccaaga agcaggagga gctgaaacag ttgaagaacc tcaagaggaa
     1081 ggagattcta gccaagctgg agaagctgcg ccaggtcact ggcaacgaga cattgggcct
     1141 tgaggagcag gacctggagg atgactttga ccctgcccag cacgaccagc tcatgcagaa
     1201 atgctttgga gatgccttct acgggactgt ggaagaagag aagccacagt ttgaggaaga
     1261 ggaggggctg gaagatgact ggaactggga cacgtggggt ggacctgagc agaatggggc
     1321 ctggagccaa caggagctgc actgtgagga ccctgacttt aacatggatg cagactatga
     1381 tcccagccaa cctcggaaga agcttcgtga agcccccacc tcaggcaaga gaaagcgcaa
     1441 gtctccgttt gcagctgcag tggggcagga gaagcccatg tttgaccctg gggacaagac
     1501 ctttgaggag tacctggatg aatactacag gctggactat gaggacatta ttgacgacct
     1561 gccttgtcgc ttcaagtacc gcactgtcgt cccctgtgac tttgggctca gcacagagga
     1621 gatcctttca gctgatgaca aggaactgaa tcgctggtgt tccctgaaga agacctgcat
     1681 gtacaggtcg gagcaggaag agatgcagga gcagcgggcg tacagccaga aggcccagag
     1741 cgtgtggaag aagaggcaga tcttcaagtc tctgtgccag gaagaggtgg aaatgcccac
     1801 agaagccaca ggaaagtcac ccagcaaggc cagctcacaa gtccagctgc ccatgcccag
     1861 tgcagctggg gggaagaagc cccaggctga gctctcagga gccaaggaag aagagttggc
     1921 ccacacaccc tgcccagaga agccagcatc ccagaagcag aagagtaaga aggccaggct
     1981 gctgggtccc acagtgacac ttggaggtca caagttcagc cgacagagat tgcaggcctt
     2041 tggcctcaac cccaaaaggc tgcacttccg ccagttgggt cgccaacgca agaaacagca
     2101 gagccacgcc tgagggccac agggagccaa cctgcctccc gggctaagct gctgaccata
     2161 ctccgcctgt tggcctaggg aagctgcctg cagcgggggc accgctgctt ctaagctggg
     2221 gaactgaggc tgccagagcc ttgtcttccc acagacaacc tgaaagtcac aaccacaggc
     2281 acactcaagt ctgcatgttt atcagcctcc actgacagtc agtcagtcct cccagtcatc
     2341 cagcgcaggc tacagaactt gaatcaggcc ctgagtgagt gccccggagc ccactccatc
     2401 cccggctcct gaggagtcag gggcagctgg gggtgaggac tcgaaagggc acaaccccaa
     2461 gctgggggcc tagataggtc tcagctgtgt tggggaggat cggggacatg aggacagggg
     2521 tccagcacca cctctggagt tccagatccc atacctgaca tgacataaat aaaaaaataa
     2581 atagtctggc atcttt
//
LOCUS       NM_001436429            3588 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus GTF2I repeat domain containing 1 (Gtf2ird1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436429 XM_063271062
VERSION     NM_001436429.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Ganaie,I.A., Malik,M.Z., Naqvi,S.H., Jain,S.K. and Wajid,S.
  TITLE     Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy
            chain variable region, and Hypertrophied skeletal muscle protein
            GTF3 in rat mammary tumorigenesis
  JOURNAL   Biochimie 174, 57-68 (2020)
   PUBMED   32325114
  REMARK    GeneRIF: Differential levels of Alpha-1-inhibitor III,
            Immunoglobulin heavy chain variable region, and Hypertrophied
            skeletal muscle protein GTF3 in rat mammary tumorigenesis.
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Palmer,S.J., Taylor,K.M., Santucci,N., Widagdo,J., Chan,Y.K.,
            Yeo,J.L., Adams,M., Gunning,P.W. and Hardeman,E.C.
  TITLE     GTF2IRD2 from the Williams-Beuren critical region encodes a
            mobile-element-derived fusion protein that antagonizes the action
            of its related family members
  JOURNAL   J Cell Sci 125 (Pt 21), 5040-5050 (2012)
   PUBMED   22899722
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Enkhmandakh,B., Makeyev,A.V., Erdenechimeg,L., Ruddle,F.H.,
            Chimge,N.O., Tussie-Luna,M.I., Roy,A.L. and Bayarsaihan,D.
  TITLE     Essential functions of the Williams-Beuren syndrome-associated
            TFII-I genes in embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 106 (1), 181-186 (2009)
   PUBMED   19109438
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Olofsson,P., Holmberg,J., Tordsson,J., Lu,S., Akerstrom,B. and
            Holmdahl,R.
  TITLE     Positional identification of Ncf1 as a gene that regulates
            arthritis severity in rats
  JOURNAL   Nat Genet 33 (1), 25-32 (2003)
   PUBMED   12461526
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Bayarsaihan,D. and Ruddle,F.H.
  TITLE     Isolation and characterization of BEN, a member of the TFII-I
            family of DNA-binding proteins containing distinct helix-loop-helix
            domains
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7342-7347 (2000)
   PUBMED   10861001
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Franke,Y., Peoples,R.J. and Francke,U.
  TITLE     Identification of GTF2IRD1, a putative transcription factor within
            the Williams-Beuren syndrome deletion at 7q11.23
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 296-304 (1999)
   PUBMED   10575229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced XM_063271062.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.50139.1,
                                           SRR26643298.80234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000012.1  27890617-27890886
            271-399             JAXUCZ010000012.1  27932371-27932499
            400-541             JAXUCZ010000012.1  27935456-27935597
            542-697             JAXUCZ010000012.1  27938763-27938918
            698-881             JAXUCZ010000012.1  27940418-27940601
            882-1192            JAXUCZ010000012.1  27945002-27945312
            1193-1282           JAXUCZ010000012.1  27945979-27946068
            1283-1366           JAXUCZ010000012.1  27947614-27947697
            1367-1550           JAXUCZ010000012.1  27954797-27954980
            1551-1576           JAXUCZ010000012.1  27958242-27958267
            1577-1685           JAXUCZ010000012.1  27960358-27960466
            1686-1723           JAXUCZ010000012.1  27961900-27961937
            1724-1804           JAXUCZ010000012.1  27962416-27962496
            1805-1894           JAXUCZ010000012.1  27963094-27963183
            1895-1942           JAXUCZ010000012.1  27966545-27966592
            1943-2008           JAXUCZ010000012.1  27967290-27967355
            2009-2192           JAXUCZ010000012.1  27968671-27968854
            2193-2242           JAXUCZ010000012.1  27970339-27970388
            2243-2299           JAXUCZ010000012.1  27970580-27970636
            2300-2383           JAXUCZ010000012.1  27973141-27973224
            2384-2567           JAXUCZ010000012.1  27975435-27975618
            2568-2596           JAXUCZ010000012.1  27976694-27976722
            2597-2674           JAXUCZ010000012.1  27989856-27989933
            2675-2867           JAXUCZ010000012.1  27990465-27990657
            2868-2905           JAXUCZ010000012.1  27991334-27991371
            2906-2983           JAXUCZ010000012.1  27992450-27992527
            2984-3176           JAXUCZ010000012.1  27993040-27993232
            3177-3214           JAXUCZ010000012.1  27994907-27994944
            3215-3348           JAXUCZ010000012.1  27996090-27996223
            3349-3588           JAXUCZ010000012.1  27997267-27997506
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3588
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I repeat domain containing 1"
                     /db_xref="GeneID:246770"
                     /db_xref="RGD:620856"
     exon            1..270
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..399
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..3417
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     general transcription factor II I repeat domain-containing
                     1; general transcription factor II-I repeat
                     domain-containing protein 1-like"
                     /codon_start=1
                     /product="general transcription factor II-I repeat
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001423358.1"
                     /db_xref="GeneID:246770"
                     /db_xref="RGD:620856"
                     /translation="MALLGKHCDIPTNGCGSERWNSTFARKDELINSLVSALDSMCSA
                     LSKLNTEVACVAVHNESVFVMGTEKGRVFLNTRKELQSDFLRFCRGPLWNDPEAGHPK
                     KVQRCEGGGRSIPRSSLEQCSDVYLLQKMVEEVFDVLYSEAMGRATVVPLPYERLLRE
                     PGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLRRPPDDGGQDTKALVEMN
                     GISLLPKGSRDCGLHGQASKVSPQDLTPTATPSSMANFLYSTSMPNHTIRELKQEVPT
                     CPLTPSDLGLGWPVPEPHVPSTQDFSDCCGQAPAGPAGPLIQNVHASKRILFSIVHDK
                     SEKWDPFIKEMEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGI
                     PDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDPMKLEPASPP
                     EDTATEVCRDSMLDLAGTAWSDMSSVSEDCGPGTSGEIGMLRPIKIEPEELDIIQVTV
                     SDPSPTSEEMTDSLPGHLPSEDSGYGMEMPADKGPSEEPWQEERPAEESPGDVIRPLR
                     KQVEMLFNTKYAKAIGTSEPVKVPYSKFLMHPEELFVLGLPEGISLRRPNCFGIAKLR
                     KILEASNSIQFVIKRPELLTDGVKEPVMDTQERDSWDPLVDETPKRQGLQENYNTRLS
                     RIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKP
                     CTFGSQNLERILSVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEK
                     YGEALGLNRPVLVPYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKARDHVR
                     MVIINQLQPFTEVCNDPKVPDEDDSNKLGKKVILREQVKELFNEKYGEALGLNRPVLV
                     PYKLIRDSPDAVEVKGLPDDIPFRNPNTYDIHRLEKILKARDHVRMVIINQLQPFGDV
                     CNNAKVPAKDNIPKRKRKRVSEGNSVSSSSSSSSSSSSNPESVASTNQISLVQWPVYM
                     VDYSGLNVQLPGPLDY"
     misc_feature    658..882
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    658..882
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1327..1551
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1327..1551
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1969..2193
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    1969..2193
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2344..2568
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2344..2568
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2635..2853
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2635..2853
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2944..3162
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     misc_feature    2944..3162
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /note="GTF2I-like repeat; Region: GTF2I; pfam02946"
                     /db_xref="CDD:460759"
     exon            400..541
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..697
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..881
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1192
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1282
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1366
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1550
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1576
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1685
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1723
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1804
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1894
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1942
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2008
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2192
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2242
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2299
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2383
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2567
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2596
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2674
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2867
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2905
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..2983
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3176
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3214
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3348
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3588
                     /gene="Gtf2ird1"
                     /gene_synonym="Gtf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacaaaga gagaacctcc cagagcccgg gctcggcttc gcgctcgctc tgcgccccgc
       61 cctccgccgc agcccgcgcc gggggtgggg gccccgcgca gcccccggcc ggccgcccgc
      121 accgcgtccg ccctccttcc ctccctccct ccactgatcc tgtcccccac tcccggatta
      181 ttaactcagc aaccagaggc gactggatct accgagtcct ggccaccggg cccgggccgg
      241 ggcgcccgga gcgcttgggg atcctgcaag gtgaccatgg ccttgctggg gaagcattgt
      301 gacatcccca ccaacggctg tgggtctgag cgctggaact ccacctttgc ccgcaaggac
      361 gagctcatca acagtctggt gtctgcctta gactccatgt gctcagcgct ctccaagctg
      421 aacacagagg tggcctgcgt ggcggtacac aatgagagcg tcttcgtgat gggcaccgag
      481 aagggaaggg tgtttttgaa tactcggaag gagctacagt cagacttcct caggttctgc
      541 cggggacccc tgtggaacga tccagaagca ggacacccta aaaaggtgca gcgctgcgaa
      601 ggtggtggcc ggagcatccc gcggtcctct ctggagcagt gctcggatgt gtacctgctg
      661 cagaagatgg tagaggaagt gtttgatgtt ctttatagtg aggctatggg cagggccacc
      721 gtggtacctt tgccctatga gaggctgctc agggagccgg ggctactggc ggtgcagggg
      781 ctgcccgagg gcctggcctt ccggagacca gcagaatatg accccaaggc actcatggcc
      841 attttggagc atagtcaccg aattcggttt aagctcagga ggcctcctga tgacggtggg
      901 caggacacaa aggcgctggt ggagatgaac ggtatctctc tgctacccaa ggggtcccga
      961 gactgtggtc tgcatggcca ggcctccaag gtctctcccc aagacctgac ccccaccgcc
     1021 accccatcct ccatggccaa cttcctgtac agcacttcga tgcccaacca caccatccgg
     1081 gaactcaagc aggaggtgcc aacctgcccg ttgaccccca gcgacctggg cttgggctgg
     1141 cctgtgcctg agccccatgt ccccagcacc caagatttct ctgattgctg tggacaggcg
     1201 cctgcagggc ctgctgggcc tctcatccag aatgtccacg cttccaagcg tatcctcttc
     1261 tccatcgtcc acgacaagtc agagaagtgg gatcccttca tcaaggaaat ggaggacatc
     1321 aacaccctgc gggagtgcgt gcagattctg tttaacagca gatacgcgga agccctgggc
     1381 ctggaccata tggttcctgt gccctacagg aagattgcct gtgaccctga ggctgtggag
     1441 attgtgggta tcccagacaa gatccccttc aagcggccct gcacttatgg agtgccgaag
     1501 ctgaagagaa ttctggagga gcggcacagc attcacttca ttatcaagag gatgttcgat
     1561 gagcgcattt tcacagggaa caagtttacc aaagacccca tgaagctgga gccagctagc
     1621 ccaccagaag acactgccac agaagtctgt agggacagca tgctggacct ggctgggact
     1681 gcttggtcag acatgagcag cgtctctgaa gactgtgggc caggaacctc aggagagata
     1741 ggaatgttga ggcctatcaa aatcgagccc gaggagctgg acattattca ggttactgtc
     1801 tcagatcctt cacctacctc tgaggagatg actgactcac tacctgggca tctaccctca
     1861 gaagattccg gttatgggat ggaaatgccg gctgacaaag gccccagtga ggaaccgtgg
     1921 caagaagaga ggccggcaga agagagccct ggtgatgtga tcaggcccct ccggaagcag
     1981 gtggaaatgc tgttcaacac aaaatatgcc aaagccattg gtacctcaga gccagtcaag
     2041 gtgccctact ccaagttcct gatgcaccca gaggagctct tcgtactggg actgcctgaa
     2101 ggcatctctc ttcgaagacc caactgcttt gggattgcca agctgaggaa gattctggaa
     2161 gccagcaaca gtatccagtt tgtcattaag agacccgaac tactcactga cggtgtcaaa
     2221 gaacctgtta tggacactca agagagggac tcctgggacc ctcttgtgga cgagaccccg
     2281 aagagacagg gccttcaaga aaattacaac accagactct ctcggatcga catcgccaac
     2341 acgcttaggg aacaagtcca agacctgttt aacaagaaat acggtgaagc tctgggcatc
     2401 aaatacccag tgcaggtgcc ctacaagcga atcaaaagca atccaggctc ggtaatcatc
     2461 gaaggcctgc cccccgggat cccattccgc aagccctgca cctttggctc ccagaacctg
     2521 gaaaggatcc tctctgtggc tgacaagatc aagttcaccg tcaccaggcc atttcaagga
     2581 ctcatcccaa agcctgatga ggatgatgcc aacagactgg gggagaaggt gatcctccga
     2641 gagcaggtga aggagctctt caatgagaaa tacggtgagg ccctgggact gaatcggcct
     2701 gtgctggtcc cgtacaagct gatccgggac agcccggatg ccgtggaggt gaaaggcctc
     2761 ccagatgaca tccccttccg gaaccccaac acctacgaca tccatcggct ggagaagatc
     2821 ctgaaggcca gagaccacgt acggatggtt atcatcaacc agctccaacc ctttacggaa
     2881 gtctgcaatg accccaaggt gccagatgag gacgactcta acaagctcgg gaagaaggtg
     2941 atcctccgag agcaggtgaa ggagctcttc aatgagaaat acggtgaggc cctgggactg
     3001 aatcggcctg tgctggtccc gtacaagctg atccgggaca gcccggatgc cgtggaggtg
     3061 aaaggcctcc cagatgacat ccccttccgg aaccccaaca cctacgacat ccatcggctg
     3121 gagaagatcc tgaaggccag agaccacgta cggatggtta tcatcaacca gctccaacct
     3181 tttggggatg tctgcaacaa tgccaaggtg ccagccaaag acaacattcc caagcgcaag
     3241 agaaagcggg tctctgaagg caactcagtc tcctcctctt cctcttcttc atcctcctcg
     3301 tcctctaatc cagagtctgt ggcgtccacc aaccagatct ccctcgtgca gtggccagtg
     3361 tacatggtgg actattccgg actaaacgtg cagcttccag gcccccttga ttattagacc
     3421 tcagagccga atcaggacct caactcaaaa gactaaagga aaatgtaatt tatgtacaaa
     3481 gtatattcgg atatgtatcg atgcctttta gtttttccaa tgatttttac actatattcc
     3541 tgccgccaag gcctttttaa ataagtaaag aaaacgaaaa agaacaaa
//
LOCUS       NM_001436421            2809 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus syntaxin binding protein 2 (Stxbp2), transcript
            variant 2, mRNA.
ACCESSION   NM_001436421 XM_006248783
VERSION     NM_001436421.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Wan,L., Chen,X. and Almers,W.
  TITLE     Munc18-dependent and -independent clustering of syntaxin in the
            plasma membrane of cultured endocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (49) (2021)
   PUBMED   34857632
  REMARK    GeneRIF: Munc18-dependent and -independent clustering of syntaxin
            in the plasma membrane of cultured endocrine cells.
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Yu,H., Shen,C., Liu,Y., Menasche,B.L., Ouyang,Y., Stowell,M.H.B.
            and Shen,J.
  TITLE     SNARE zippering requires activation by SNARE-like peptides in
            Sec1/Munc18 proteins
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8421-E8429 (2018)
   PUBMED   30127032
  REMARK    GeneRIF: SNARE zippering requires activation by SNARE-like peptides
            in Sec1/Munc18 proteins
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Qin,T., Liang,T., Zhu,D., Kang,Y., Xie,L., Dolai,S., Sugita,S.,
            Takahashi,N., Ostenson,C.G., Banks,K. and Gaisano,H.Y.
  TITLE     Munc18b Increases Insulin Granule Fusion, Restoring Deficient
            Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat
            Islets with Improvement in Glucose Homeostasis
  JOURNAL   EBioMedicine 16, 262-274 (2017)
   PUBMED   28163042
  REMARK    GeneRIF: Data show that Munc18b overexpression increased fusion of
            not only newcomer secretory granule (SG), but also predocked SGs in
            type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets.
REFERENCE   4  (bases 1 to 2809)
  AUTHORS   Gandasi,N.R. and Barg,S.
  TITLE     Contact-induced clustering of syntaxin and munc18 docks secretory
            granules at the exocytosis site
  JOURNAL   Nat Commun 5, 3914 (2014)
   PUBMED   24835618
  REMARK    GeneRIF: Secretory vesicles dock by inducing syntaxin1/munc18
            clustering in the target membrane.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2809)
  AUTHORS   Brochetta,C., Suzuki,R., Vita,F., Soranzo,M.R., Claver,J.,
            Madjene,L.C., Attout,T., Vitte,J., Varin-Blank,N., Zabucchi,G.,
            Rivera,J. and Blank,U.
  TITLE     Munc18-2 and syntaxin 3 control distinct essential steps in mast
            cell degranulation
  JOURNAL   J Immunol 192 (1), 41-51 (2014)
   PUBMED   24323579
  REMARK    GeneRIF: Munc18-2 and STX3 perform distinct, but complementary,
            functions to support, respectively, SG translocation and membrane
            fusion in mast cells.
REFERENCE   6  (bases 1 to 2809)
  AUTHORS   Coppola,T., Frantz,C., Perret-Menoud,V., Gattesco,S., Hirling,H.
            and Regazzi,R.
  TITLE     Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and
            controls exocytosis
  JOURNAL   Mol Biol Cell 13 (6), 1906-1915 (2002)
   PUBMED   12058058
  REMARK    GeneRIF: binds to granuphilin and controls exocytosis of pancreatic
            beta cells
REFERENCE   7  (bases 1 to 2809)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   8  (bases 1 to 2809)
  AUTHORS   Lehtonen,S., Riento,K., Olkkonen,V.M. and Lehtonen,E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   9  (bases 1 to 2809)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   10 (bases 1 to 2809)
  AUTHORS   Katagiri,H., Terasaki,J., Murata,T., Ishihara,H., Ogihara,T.,
            Inukai,K., Fukushima,Y., Anai,M., Kikuchi,M., Miyazaki,J. et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006248783.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.847246.1,
                                           SRR26360186.2080487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000012.1  6487319-6487368
            51-100              JAXUCZ010000012.1  6488356-6488405
            101-182             JAXUCZ010000012.1  6488636-6488717
            183-259             JAXUCZ010000012.1  6489296-6489372
            260-338             JAXUCZ010000012.1  6490140-6490218
            339-442             JAXUCZ010000012.1  6490315-6490418
            443-591             JAXUCZ010000012.1  6490792-6490940
            592-676             JAXUCZ010000012.1  6491530-6491614
            677-807             JAXUCZ010000012.1  6491691-6491821
            808-915             JAXUCZ010000012.1  6491903-6492010
            916-973             JAXUCZ010000012.1  6492262-6492319
            974-1039            JAXUCZ010000012.1  6492427-6492492
            1040-1120           JAXUCZ010000012.1  6492573-6492653
            1121-1259           JAXUCZ010000012.1  6493124-6493262
            1260-1369           JAXUCZ010000012.1  6495264-6495373
            1370-1465           JAXUCZ010000012.1  6496468-6496563
            1466-1551           JAXUCZ010000012.1  6497074-6497159
            1552-1709           JAXUCZ010000012.1  6497237-6497394
            1710-2809           JAXUCZ010000012.1  6497939-6499038
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2809
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="syntaxin binding protein 2"
                     /db_xref="GeneID:81804"
                     /db_xref="RGD:619967"
     exon            1..50
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="upstream in-frame stop codon"
     CDS             14..1795
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     unc-18B; unc18-2; unc-18 homolog 2; unc-18 homolog B;
                     munc18-2; protein unc-18 homolog 2; protein unc-18 homolog
                     B; syntaxin binding protein Munc18-2"
                     /codon_start=1
                     /product="syntaxin-binding protein 2 isoform 2"
                     /protein_id="NP_001423350.1"
                     /db_xref="GeneID:81804"
                     /db_xref="RGD:619967"
                     /translation="MAPLGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSC
                     CKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAA
                     HIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPF
                     RAGERGRQLDVLAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPS
                     LGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLHIEQDTYRYETTGLSESRE
                     KAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMP
                     QYQKELNKYSTHLHLADDCMKHFKGSVEKLCGVEQDLAMGSDAEGEKIKDTMKLIVPV
                     LLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSNLIRNLEQLGGTVTN
                     SAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVSSS
                     QAAVSARFGHWHKNKAGIEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIG
                     SSHILTPTRFLDDLRTLDQKLEDIALP"
     misc_feature    98..1750
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="Sec1 family; Region: Sec1; pfam00995"
                     /db_xref="CDD:460020"
     misc_feature    98..1750
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /note="Sec1 family; Region: Sec1; pfam00995"
                     /db_xref="CDD:460020"
     exon            51..100
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            101..182
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            183..259
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            260..338
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            339..442
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            443..591
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            592..676
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            677..807
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            808..915
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            916..973
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1039
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1120
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1259
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1369
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1465
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1551
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1709
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..2809
                     /gene="Stxbp2"
                     /gene_synonym="Munc18b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttagggg aagatggcgc ccttggggct gaaggcggtg gtgggggaaa aaattctaag
       61 tggagtcatc cggagcgtta agaaggatgg cgagtggaag gtactcatca tggatcatcc
      121 gagcatgcga atcttgtcat cctgttgtaa aatgtcagat atcttggcgg agggcatcac
      181 cattgtggaa gacatcaaca aacggagaga acccattccc agcttggagg caatttattt
      241 gctgagtccc acagagaagt cggttcaggc tctgattgcg gacttccagg ggacaccaac
      301 cttcacctac aaagcagccc atatcttctt cacggacacg tgccccgagc ccttgttcag
      361 tgaactgggc cgctctcgcc tggcgaaggt ggtgaagaca ctgaaagaga tccacctcgc
      421 cttcctcccc tatgaggccc aggtgttctc tctggatgcc ccgcacagca cctataacct
      481 ttattgccca tttcgggcag gggagcgggg gcggcagctc gatgtgctgg cccagcagat
      541 agccacactg tgtgccactc ttcaggaata cccatccatt cgctaccgca agggcccaga
      601 agacacagcc cagctggccc atgctgtcct ggccaagctg aacgccttca aggcagacac
      661 tcccagtctg ggcgagggcc cagagaaaac acgctcacag ttgctcataa tggaccgggc
      721 agcagacccc gtgtccccgc tattacatga actcacattc caagccatgg cctatgatct
      781 tctgcacatc gagcaggaca catacaggta tgagaccaca ggactgagcg agtcccggga
      841 gaaggctgtg ctcctggatg aagacgatga cctgtgggtg gaactccggc acatgcacat
      901 agcggatgtg tccaagaagg tcacggagct cctgaagaca ttctgtgaga gcaagcggct
      961 gaccacagac aaggccaaca tcaaagacct gtcccacatc ctgaaaaaga tgccacagta
     1021 tcagaaggag ttgaacaagt actccacgca cctgcacttg gcagatgact gcatgaagca
     1081 cttcaagggc tcggtggaga agctgtgcgg tgtggagcag gacctggcca tgggctctga
     1141 tgcagagggt gagaagatca aggacaccat gaaactgatt gtcccggtgc tgttggatgc
     1201 ctccgtgcca ccctatgaca agatccgggt tctgctgctc tacatccttc tgcggaacgg
     1261 tgtgagtgag gaaaatctgg ccaagctgat ccagcatgct aatgtgcagt cctacagcaa
     1321 cctcatccgg aacctggagc agctgggggg cactgtcacc aactctgcgg gctcagggac
     1381 ctctagccgg ctggagcgga gagaacgcat ggagcccacc taccagctgt ctcgctggtc
     1441 cccagtcatc aaggacgtga tggaggatgt ggtggaggac cggctagacc gaaagctgtg
     1501 gcccttcgtg tctgaccctg cccctgtgtc tagctcccaa gcagctgtca gtgctcgctt
     1561 tggccactgg cataaaaaca aagctggtat agaggctcgg gctggaccca ggctcatcgt
     1621 gtacattgtg ggtggtgtcg ccatgtctga aatgagggct gcttatgagg tgaccagggc
     1681 cactgaaggc aagtgggagg tacttatagg ctcttcccac atcctcactc caacccgctt
     1741 cctcgatgac ctcaggaccc tggatcagaa gctggaggac atagccctgc cctgactcag
     1801 ctgcttgctc tgccctctcc tcctgttcca gagaaataaa ctcttccctt catctttcca
     1861 tcagggctca cctcactttc ttcccagaga gagctgtata aaccagaccc atgctgccgg
     1921 cctcccctta tgttactgtt ctgcctgaac cttcccttgg cccccagaag cagctttagc
     1981 ttccatgaac gttgggaacc tgggctctgg ctctctggct gggtccctcc atccaaaccc
     2041 tgatcttagc agacaaactg cagaggagac agagagctgc caatcaggga atggcagggc
     2101 tgcaacccca ttgtcactag aattctttag gctgtttggt tagaattata gaaaaaacct
     2161 taacctttct ctttattttg tgttacactt gtgtgtctgt ctgtgcatca catgcatcag
     2221 tgcctgtaga ggtcagaata gggtgcggga tccccgggac caggtataga tggttgtgag
     2281 aagccaggag atgcttgggt ctgctgcaag aacagccagt cccttgacca ctgaggcatc
     2341 tccagctcta gaaatagaag caggtagagt aggcccggat cctgactctt cccctggatc
     2401 ctcccaggaa ctactgcaag tggaacttga agccccaatt ctgggaatca gagccagcat
     2461 ttaaagcaca gcaaactcaa acaccggttt cctagtggcc cccaccctcc tccagcctta
     2521 ggatatgcct gtaggttctg attgcaggat ttaccagagt ttttaatgga gaacttataa
     2581 actattcctg ggcctggatg gctcagaggt taagagtgtt tgctgctctt ccagaggcct
     2641 ggatttggtt cccaacactc acattgcgtg gctcaaagct gcttgtaact ccagctccag
     2701 gggatttggt gctctctccc ggtttcagtg ggagccgaga tacatgtgtg ccctgccccc
     2761 acacaccaat aaacaaataa acagacaata aataaaagca ctccactca
//
LOCUS       NM_001436419            5866 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus BCL9 like (Bcl9l), transcript variant 1, mRNA.
ACCESSION   NM_001436419 XM_017595551
VERSION     NM_001436419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5866)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5866)
  AUTHORS   Deka,J., Wiedemann,N., Anderle,P., Murphy-Seiler,F., Bultinck,J.,
            Eyckerman,S., Stehle,J.C., Andre,S., Vilain,N., Zilian,O.,
            Robine,S., Delorenzi,M., Basler,K. and Aguet,M.
  TITLE     Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell
            traits in colon epithelium and adenocarcinomas
  JOURNAL   Cancer Res 70 (16), 6619-6628 (2010)
   PUBMED   20682801
REFERENCE   3  (bases 1 to 5866)
  AUTHORS   Brack,A.S., Murphy-Seiler,F., Hanifi,J., Deka,J., Eyckerman,S.,
            Keller,C., Aguet,M. and Rando,T.A.
  TITLE     BCL9 is an essential component of canonical Wnt signaling that
            mediates the differentiation of myogenic progenitors during muscle
            regeneration
  JOURNAL   Dev Biol 335 (1), 93-105 (2009)
   PUBMED   19699733
REFERENCE   4  (bases 1 to 5866)
  AUTHORS   Fritzmann,J., Morkel,M., Besser,D., Budczies,J., Kosel,F.,
            Brembeck,F.H., Stein,U., Fichtner,I., Schlag,P.M. and Birchmeier,W.
  TITLE     A colorectal cancer expression profile that includes transforming
            growth factor beta inhibitor BAMBI predicts metastatic potential
  JOURNAL   Gastroenterology 137 (1), 165-175 (2009)
   PUBMED   19328798
REFERENCE   5  (bases 1 to 5866)
  AUTHORS   Adachi,S., Jigami,T., Yasui,T., Nakano,T., Ohwada,S., Omori,Y.,
            Sugano,S., Ohkawara,B., Shibuya,H., Nakamura,T. and Akiyama,T.
  TITLE     Role of a BCL9-related beta-catenin-binding protein, B9L, in
            tumorigenesis induced by aberrant activation of Wnt signaling
  JOURNAL   Cancer Res 64 (23), 8496-8501 (2004)
   PUBMED   15574752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 12, 2025 this sequence version replaced XM_017595551.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.848865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-662               JAXUCZ010000008.1  53708770-53709431
            663-719             JAXUCZ010000008.1  53715342-53715398
            720-821             JAXUCZ010000008.1  53725123-53725224
            822-1207            JAXUCZ010000008.1  53726436-53726821
            1208-1327           JAXUCZ010000008.1  53727472-53727591
            1328-1538           JAXUCZ010000008.1  53732120-53732330
            1539-1623           JAXUCZ010000008.1  53732498-53732582
            1624-3910           JAXUCZ010000008.1  53732666-53734952
            3911-4192           JAXUCZ010000008.1  53735238-53735519
            4193-5866           JAXUCZ010000008.1  53735724-53737397
FEATURES             Location/Qualifiers
     source          1..5866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..5866
                     /gene="Bcl9l"
                     /note="BCL9 like"
                     /db_xref="GeneID:300673"
                     /db_xref="RGD:1309096"
     exon            1..662
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    640..642
                     /gene="Bcl9l"
                     /note="upstream in-frame stop codon"
     exon            663..719
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            720..821
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..5280
                     /gene="Bcl9l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell CLL/lymphoma 9-like protein"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 9-like protein isoform 1"
                     /protein_id="NP_001423348.1"
                     /db_xref="GeneID:300673"
                     /db_xref="RGD:1309096"
                     /translation="MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKL
                     TNHGKTGNGGAQSQHQNVNQGPTCNLGSKGVGAGSHGAKANQISPSNSSLKNPQAGVS
                     PFSSLKGKVKRERSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEW
                     CSGPDSEEDDKPIGATHNCNVADPAMVAPQLGPGQTAQLPLSENSAPGPQHGPPPGLR
                     PDVPGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRAESILAYHQQNVPRAKLDQ
                     APKVPPTPEPLPLNTPSAGTPQSQPPPLPPPPPAPGSAPPALPQEGPPEDTSQDLAPN
                     SVGAASTGGGTGGTHPNTPTAATANNPLPPGGDPGSAPGSALLGEATPTGNGQRNLVG
                     SEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAVEGGPPAQAPSAAQQ
                     PPSAPPPGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPQGGDMGQQMNMMMQRLGQD
                     SLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGGRPLQDMVGMGGMMGRGPPPPYHSKPG
                     DQWPPGMGTQLRGPMDVQDPMQLRPGPPFPGPRFPGNQMQRVPGFGGMQSIPMEVPMN
                     AMQRPVRPGMAWNEDLPPIGGPSNFAQNAVPYPGGQGEAERFMTPRVREELLRHQLLE
                     KRSMGMQRPLGMAGSGMGQSMEMERMIQTHRQMDPTMFPGQMTGGDGLAGTPMGIEFG
                     GGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMR
                     GPGDMMGPQGLSPEEMARVRAQNSSGMMAGPQKMLMPSQFPNQGQQGFSGGQGPYQAM
                     PQDMGNTPDMFSPDQSSVPMGAVGTARLSHMPLPPASNPPGSVHSAPNRGLGRRPSDL
                     TISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKS
                     PQVLSSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNINSS
                     STLGNLEQGALPPAGPRNSSSAPPANPPSSLMNPSLPFTSSPDPTPSQNPLSLMMSQM
                     SKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNNQPNQMHMNP
                     AAAQSPMGMNLPGQQPLSHEPPPTMLPSPTPLGSNIPLHPNAQGTGGPSQNSMMMAPG
                     GPDSLNTPCGPVPSSSQMMSFPPRLQQPHGAMAATGGGGPGLQQHYPSGMALPPEDLP
                     NQPPGPIPSQQHLMGKGMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTGIPEFD
                     LSRIIPSEKPSSTLQYFPKNENQPPKAQPPNLHLMNLQNMMAEQAPSRPPNLPGQQGV
                     QRGLSMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLMKQRGV
                     GGEVYTQPPHMLSPQGSLMAPPPQQNLMVSHPLRQRSVSLDSQMGYLPTPGGMANLPF
                     "
     misc_feature    1978..2088
                     /gene="Bcl9l"
                     /note="B-cell lymphoma 9 protein; Region: BCL9; pfam11502"
                     /db_xref="CDD:431912"
     misc_feature    1978..2088
                     /gene="Bcl9l"
                     /note="B-cell lymphoma 9 protein; Region: BCL9; pfam11502"
                     /db_xref="CDD:431912"
     misc_feature    <3457..4848
                     /gene="Bcl9l"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3457..4848
                     /gene="Bcl9l"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            822..1207
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1327
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1538
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1623
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..3910
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4192
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..5866
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagtgga ggggcgagcg tggctccggc agcgcagggg atcccgggga ggcggcggcg
       61 cgcggcggag ccagtggccg gacatgcccc ggatccgggg ccgctgcagc accgccgccg
      121 cccggagcca gccggccgga cgcccgcacg cctgggtccc ctggcgccgc gccgcccggg
      181 ggctgcgatc tggaccctcg gcatccgacc aacaataagc gcctagacag ccccctcccc
      241 gccccgtgcc cgccgtcccc gcgggcctcg gggaaagtga aaggaggagg cgaaggaagg
      301 aaggaaggaa ggaagggagg aggaggagca ggagcggcag cagccggagc tgggaggttt
      361 gggccgagac cccagcccgg agcccgggca cggcggtgcg gtagctctcc cgctgctgcc
      421 ggcgcccagg accatgctcc gcggttggga ggcaggaacc caggcaacca gcgcctccgg
      481 gatacctgct cgcgggccgg gctggtatta agatcaaggc gtccaggatc aaaaagacca
      541 ccgcctgccc gccttctcca cgactccacc gtcctgctgg aggatcccag tccacccaac
      601 gaccctgatc tggttatggc gtccagctcc ggcctggcgt gaggaccccc gaccggtgcg
      661 agggagcccc catcccagac cacacccctg agcctgaacc tgacacacat tcctcagagt
      721 ccctgctcca gtaccgagta cctggctggg ccctgggcac gcacaggggt cgtagcccca
      781 ctgtgtgtgg gagccatgag gatcctggct aacaagacaa ggttacccca ccccaggagg
      841 agagaggctc cagggagtcc accgctgtcc cctcgaggcc actgcccccc tgccccagcc
      901 aagccaatgc acccagaaaa taaattgacc aatcatggca agacagggaa tggaggggcc
      961 caatcccagc accagaatgt gaaccaagga cccacctgca acctgggctc caagggcgtg
     1021 ggggcgggga gccatggggc caaggccaac cagatctcac ccagcaactc aagtctgaag
     1081 aacccccagg caggagtgtc tcctttcagc tccctcaaag gcaaggtgaa gcgagagcgg
     1141 agtgtgtccg tggactctgg agagcagcga gaagccggaa ctccatccct ggattcagag
     1201 gccaaagagg tggcaccccg gagtaaacgg aggtgtgtgc tggagcggaa gcagccatac
     1261 agtggggatg aatggtgctc tggaccagac agcgaggagg acgacaagcc cattggggcc
     1321 acccacaatt gtaatgtagc agacccagcc atggtggccc cacagttggg tcctggccaa
     1381 actgcccaac tgcccctcag tgagaacagt gcaccaggcc cccaacatgg ccccccgcca
     1441 ggccttcggc cagacgtccc tgggggtggg ggtgggggcg tcccaggaaa gcctccgtct
     1501 cagttcgtgt acgtcttcac cacccatctg gccaacacgg cggcagaagc agtgctacag
     1561 ggccgggcag agtccatcct cgcctaccac cagcagaacg tgccccgggc caagctggat
     1621 caggccccta aagtgccacc caccccagaa ccactacccc tgaacacgcc atcagcaggt
     1681 acaccacagt cccagccacc tccgttgcca ccgccaccac cagcccctgg cagtgcccct
     1741 cctgctctgc cccaggaggg gcctcctgaa gacaccagtc aggacctggc ccccaactca
     1801 gtgggagctg ccagcacagg tggtgggact gggggcaccc accccaacac cccaacggct
     1861 gccactgcta acaaccctct gcctcctgga ggagaccctg gcagtgctcc tggctctgcc
     1921 ctattgggcg aggccacgcc cacaggaaat gggcagagga acctggtggg ctctgagggc
     1981 ctgtccaaag agcagctgga gcaccgtgag cgctccctcc agacacttcg agacatagag
     2041 aggctgctgc tccgcagcgg ggagactgag cccttcctca aggggccccc tggaggagct
     2101 gttgagggag gcccgcccgc acaagcgccc tctgccgctc agcagcctcc ctccgcccct
     2161 cctccggggc tgaagaagta cgaggaacct ctgcagtcaa tgatttcaca gacacagagc
     2221 cttggaggcc ccccattgga gcacgaggtg ccggggcacc ctcagggcgg agacatggga
     2281 cagcaaatga acatgatgat gcagaggctg ggccaggaca gtctgacacc tgagcaggtg
     2341 gcctggcgca aactgcagga agagtactac gaggagaagc ggcggaaaga ggagcagatt
     2401 ggattgcatg ggggccgccc tctgcaggac atggtgggaa tggggggcat gatggggagg
     2461 gggcccccac ctccttacca cagcaaacct ggggatcagt ggccacctgg gatgggcacg
     2521 caactccgag gacctatgga tgtccaagat cccatgcagc tccgacctgg acctcccttc
     2581 cccggccccc gtttcccagg caaccagatg caaagggtgc ctggctttgg aggtatgcag
     2641 agtataccca tggaagtacc catgaatgcc atgcagagac ctgtaaggcc gggcatggcc
     2701 tggaatgaag acttgccccc tattggggga cccagcaact ttgcccagaa tgctgtgccc
     2761 tatccaggtg ggcagggtga ggcagagcgg ttcatgaccc ctcgtgtccg ggaggagctg
     2821 ctgaggcacc agttgctgga gaagcggtca atgggcatgc agcggcccct gggcatggcg
     2881 ggtagtggca tgggacagag catggaaatg gaacggatga tacagacaca tcgacagatg
     2941 gaccctacca tgttcccagg gcagatgact ggaggagatg gtctggctgg cactcccatg
     3001 ggcatagagt tcggtggagg ccggggcctc ctgagccctc caatgggaca gtctgggctg
     3061 agggaggtag acccacccat gggaccgggc aacctcaaca tgaacatgaa tgtcaacatg
     3121 aacatgaaca tgaacctgaa tgtgcagatg acgccacagc agcagatgct gatgtcacag
     3181 aagatgcgag gccctggaga catgatgggt cctcagggcc tcagtcctga ggagatggct
     3241 cgagttcggg cccagaacag tagtggcatg atggcgggtc cacagaagat gctcatgcct
     3301 tctcagtttc ccaaccaggg ccagcaggga ttctctgggg gccagggacc ctaccaagcc
     3361 atgccccagg acatgggcaa cactccagac atgtttagcc ctgatcagag ttcagtgccc
     3421 atgggcgctg tgggcaccgc ccggctcagc catatgcctc tgccccctgc atccaatccc
     3481 cctgggtctg tgcactcagc ccccaatagg gggcttggca ggcggccttc agatctcacc
     3541 atcagtatta atcagatggg ctcaccaggc atggggcatc tgaagtcacc cacccttagc
     3601 caggtgcact ccccgctggt cacctcaccc tctgccaacc ttaagtcacc ccagactccc
     3661 tcacagatgg tacccttgcc ttctgccaac ccaccaggac ctctcaagtc accccaggtc
     3721 ctcagctctt ccctcagtgt gcgttcaccc actggctcac ccagcaggct caagtctccc
     3781 tccatggcgg tgccttctcc gggctgggtc gcctctccca agacagccat gcctagtcct
     3841 ggggtctccc agaataaaca gccacctctc aacataaact cttcctctac cctgggcaac
     3901 ctggaacagg gtgctctccc acctgctggc ccccggaaca gctcctcagc tcctcccgcc
     3961 aaccctccca gcagcctcat gaatcccagc ctaccgttca catcctcccc agaccccacg
     4021 ccttcccaga accctctgtc actgatgatg tctcagatgt ccaagtatgc catgcccagc
     4081 tctaccccgc tgtaccacaa tgccatcaag accatcgcca cctcagatga cgagttgctg
     4141 cctgaccggc ccctgctacc cccaccccca ccaccgcagg gctctgggcc aggtatcagc
     4201 aacaaccagc ccaaccagat gcatatgaac cctgctgctg cccagagccc catgggcatg
     4261 aacttgccag gccagcagcc cctgtcccat gagcctccac ctactatgtt gccctccccc
     4321 acccctctgg ggtccaacat tccactgcac cccaatgcac aggggactgg gggcccttct
     4381 caaaactcaa tgatgatggc cccaggaggc ccagactccc taaatacccc ttgtggccct
     4441 gtgcccagct cttcccagat gatgtccttt cctcctcggc tgcagcaacc ccatggtgcc
     4501 atggccgcca ctgggggtgg ggggcctggc ctgcagcagc actacccttc aggcatggcc
     4561 ctgccccctg aggacctgcc caaccagcca cctggtccca taccctccca gcagcacctg
     4621 atgggcaaag gcatggctgg ccgcatgggc gatgcgtacc caccgggggt actccctggg
     4681 gtggcatcgg tactgaatga cccagagctg agtgaggtga tccggcccac ccctaccggc
     4741 attcctgagt tcgacttatc cagaatcatc ccctctgaga aaccgagcag caccctccaa
     4801 tacttcccca agaacgagaa ccagcccccc aaggcccagc cccccaatct gcacctcatg
     4861 aacctgcaga acatgatggc ggagcaggcc ccgtctcggc cccccaacct cccaggccaa
     4921 cagggggtcc agcggggtct cagcatgtcc atgtgccacc ctggacagat gtccttgctg
     4981 ggcaggacag gtgtgccccc acagcagggc atggtgcccc acggcctgca ccagggggtc
     5041 atgtcccctc cacagggcct catgacccag cagaatttta tgctgatgaa acagaggggc
     5101 gtggggggtg aggtctacac ccagcctccc cacatgctct ccccacaggg ctccctcatg
     5161 gcccccccac cccagcagaa cctcatggtg tcccaccctc tgcggcagcg cagtgtgtct
     5221 ctggacagcc agatgggcta cctcccaacg ccgggcggca tggccaatct acccttctag
     5281 caggcccctc ggtttggagc tggggatact gaaaatacgt taactttaaa aagttttgct
     5341 tttcctccag tgttgggatg gatggcctgg gtccaggggt agggtggagg ggagggatag
     5401 ggcttgtgtg gggagtggcg tttgtggaaa cctgatgtgc tggcagctta gggggggagc
     5461 ggcaagtgtc ggtgaggagt tggaattggg gtttgctcca tttctgacac caggaccgct
     5521 cctccccggc ccccctagtc ccacggagct tctgttcccc gtcgtctttg cccctccccg
     5581 ctttcagctg tgtttcgggg gtccttgggg agagaggagg gtcttccatc ctctgacctg
     5641 ttgtggacag gtcggtttct ctccgccggg tctctctgct ttgaccccgt tttccttctg
     5701 cctcatttcc tctccctact gacgtggctg acctcctctc ccacgccccc tgcaggcagc
     5761 tggccaggtg ggcaggtgtc agcggagctg taaatagagc tgcgcttttg tgccggtttg
     5821 tgcgtgtgcc gtatttctgt gttttgatag aagtcacaca caaggg
//
LOCUS       NM_001436428            1448 bp    mRNA    linear   ROD 14-MAR-2025
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase 1A (Oas1a),
            transcript variant 1, mRNA.
ACCESSION   NM_001436428 XM_006249382
VERSION     NM_001436428.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Leisching,G., Cole,V., Ali,A.T. and Baker,B.
  TITLE     OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and
            enhance cytokine secretion
  JOURNAL   Int J Infect Dis 80S, S77-S84 (2019)
   PUBMED   30822544
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Sarmiento,L., Frisk,G., Anagandula,M., Hodik,M., Barchetta,I.,
            Netanyah,E., Cabrera-Rode,E. and Cilio,C.M.
  TITLE     Echovirus 6 Infects Human Exocrine and Endocrine Pancreatic Cells
            and Induces Pro-Inflammatory Innate Immune Response
  JOURNAL   Viruses 9 (2), 25 (2017)
   PUBMED   28146100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Kim,S., Kim,M.J., Park,D.Y., Chung,H.J., Kim,C.H., Yoon,J.H. and
            Kim,H.J.
  TITLE     Mitochondrial reactive oxygen species modulate innate immune
            response to influenza A virus in human nasal epithelium
  JOURNAL   Antiviral Res 119, 78-83 (2015)
   PUBMED   25930096
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Go,M.J., Hwang,J.Y., Kim,Y.J., Hee Oh,J., Kim,Y.J., Heon Kwak,S.,
            Soo Park,K., Lee,J., Kim,B.J., Han,B.G., Cho,M.C., Cho,Y.S. and
            Lee,J.Y.
  TITLE     New susceptibility loci in MYL2, C12orf51 and OAS1 associated with
            1-h plasma glucose as predisposing risk factors for type 2 diabetes
            in the Korean population
  JOURNAL   J Hum Genet 58 (6), 362-365 (2013)
   PUBMED   23575436
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Donovan,J., Dufner,M. and Korennykh,A.
  TITLE     Structural basis for cytosolic double-stranded RNA surveillance by
            human oligoadenylate synthetase 1
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), 1652-1657 (2013)
   PUBMED   23319625
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Hartmann,R., Walko,G. and Justesen,J.
  TITLE     Inhibition of 2'-5' oligoadenylate synthetase by divalent metal
            ions
  JOURNAL   FEBS Lett 507 (1), 54-58 (2001)
   PUBMED   11682059
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Truve,E., Aaspollu,A., Honkanen,J., Puska,R., Mehto,M., Hassi,A.,
            Teeri,T.H., Kelve,M., Seppanen,P. and Saarma,M.
  TITLE     Transgenic potato plants expressing mammalian 2'-5' oligoadenylate
            synthetase are protected from potato virus X infection under field
            conditions
  JOURNAL   Biotechnology (N Y) 11 (9), 1048-1052 (1993)
   PUBMED   7764002
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Shiojiri,S., Fukunaga,R., Ichii,Y. and Sokawa,Y.
  TITLE     Structure and expression of a cloned cDNA for human
            (2'-5')oligoadenylate synthetase
  JOURNAL   J Biochem 99 (5), 1455-1464 (1986)
   PUBMED   3754863
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Wathelet,M., Moutschen,S., Cravador,A., DeWit,L., Defilippi,P.,
            Huez,G. and Content,J.
  TITLE     Full-length sequence and expression of the 42 kDa 2-5A synthetase
            induced by human interferon
  JOURNAL   FEBS Lett 196 (1), 113-120 (1986)
   PUBMED   3753689
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Shimizu,N. and Sokawa,Y.
  TITLE     (2'-5')Oligoadenylate synthetase in pig spleen: isolation and
            characterization
  JOURNAL   J Biochem 94 (5), 1421-1428 (1983)
   PUBMED   6654863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 12, 2025 this sequence version replaced XM_006249382.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086979.1, FQ231421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000012.1  41330445-41330695
            252-540             JAXUCZ010000012.1  41332063-41332351
            541-725             JAXUCZ010000012.1  41334998-41335182
            726-958             JAXUCZ010000012.1  41338519-41338751
            959-1112            JAXUCZ010000012.1  41339378-41339531
            1113-1139           JAXUCZ010000012.1  41340637-41340663
            1140-1448           JAXUCZ010000012.1  41340818-41341126
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1448
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5' oligoadenylate synthetase 1A"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
     exon            1..251
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1172
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate
                     synthase 1; 2'-5' oligoadenylate synthetase 1G; 2-5A
                     synthetase 1; (2-5')oligo(A) synthetase 1; 2-5A synthase
                     1; (2-5')oligo(A) synthase 1; 2',5'-oligoadenylate
                     synthetase 1, 40/46kDa; 25 oligoadenylate synthetase; 2-5A
                     synthase 1A; (2-5')oligo(A) synthase 1A;
                     2'-5'-oligoadenylate synthase 1A"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase 1A isoform 1"
                     /protein_id="NP_001423357.1"
                     /db_xref="GeneID:192281"
                     /db_xref="RGD:621760"
                     /translation="MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKE
                     RCFRDTVHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKE
                     IKKQLYEVQREKHFRVKFEVQSSWWPNPRALSFKLSAPHLQQEVEFDVLPAYDVLGHV
                     SLYSNPDPKIYTILISECISLGKEGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQ
                     LCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQGFRTILELVTKYQQLRIYWTK
                     YYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRRLASEARLWLQYPCF
                     MNRGGSPVSSWEVPTEVPVPSEQVDEAWSCILL"
     misc_feature    147..569
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    147..569
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    order(252..260,267..269,273..281,294..296,300..302,
                     450..455,462..464,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(252..260,267..269,273..281,294..296,300..302,
                     450..455,462..464,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(294..296,300..302,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    order(294..296,300..302,513..515)
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    558..1118
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    558..1118
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     exon            252..540
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            541..725
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            726..958
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1112
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1139
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1448
                     /gene="Oas1a"
                     /gene_synonym="Oas1; Oas1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttccaagt tcaaccaggc tgcgagacac aggacctgca ggctgcagag gcaaaagctc
       61 cggaggtcat ggagcaggaa ctcaggagca ccccgtcctg gaagctggac aagttcatag
      121 aggtttacct ccttccaaac accagcttcc gtgatgatgt caaatcagct atcaatgtcc
      181 tgtgtgattt cctgaaggag agatgcttcc gagatactgt ccacccagtg agggtctcca
      241 aggtggtgaa gggcggctcc tcaggcaaag gcaccacact caagggcaag tcagacgctg
      301 acctggtggt gttccttaac aatttcacca gctttgagga tcagttaaac agacggggag
      361 agttcatcaa ggaaattaag aaacagctgt atgaggttca gcgtgaaaaa cattttagag
      421 tgaagtttga ggtccagagt tcatggtggc ccaacccccg ggctctgagc ttcaagctga
      481 gtgcaccaca cctccaacag gaggtggagt ttgatgtgct tccagcctat gatgtcctag
      541 gtcatgttag cctctacagc aatcctgatc ccaagatcta caccatcctc atctccgaat
      601 gtatctccct ggggaaggag ggcgagttct ctacctgctt cacggagctc cagaggaact
      661 tcctgaagca gcgcccaacc aagcttaaga gtctcatccg cctggtcaag cactggtacc
      721 aactgtgtaa ggagaagctg gggaagccgc tgcccccaca gtacgccctg gagctgctca
      781 cggtctatgc ctgggaacgt ggaaatggaa ttactgagtt caacacagct cagggcttcc
      841 ggacaatctt ggaactggtc acaaagtacc agcagcttcg aatctactgg acaaagtatt
      901 atgactttca acacccagat gtctccaaat acctacacag acagctcaga aaatccaggc
      961 ctgtgatcct ggaccctgct gacccaacag ggaacgtggc tggtgggaac caagaaggct
     1021 ggcggcggtt ggcctcagag gcgaggctgt ggctgcagta cccatgtttt atgaacaggg
     1081 gtggttcccc agtgagctcc tgggaagtgc cgacagaggt tcctgtgcct tcagagcagg
     1141 tggatgaggc ctggtcatgc atcctgctgt gaacccagca gcaccagccc aggaggctcc
     1201 ggagtcaggg gcacgtgctg ctctgctgca ggaccttgac acagtgaggg agggccccac
     1261 tcgggatcac agtccatgct tctgatgccc gcccgccatg tttgaatact gtccaatcac
     1321 agacagcctt cctcaacaga ttcagaaggg gcggaaagaa ctcaagcttg acttccatct
     1381 gaccgtccac ctgttgggag gttctgtcca accatgtctg tcaacaacaa taaagtacag
     1441 caggtgcc
//
LOCUS       NM_001004080            2612 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus gelsolin (Gsn), mRNA.
ACCESSION   NM_001004080 XM_216043
VERSION     NM_001004080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2612)
  AUTHORS   Benavente-Fernandez,I., Ramos-Rodriguez,J.J., Infante-Garcia,C.,
            Jimenez-Gomez,G., Lechuga-Sancho,A., Lubian-Lopez,S. and
            Garcia-Alloza,M.
  TITLE     Altered plasma-type gelsolin and amyloid-beta in neonates with
            hypoxic-ischaemic encephalopathy under therapeutic hypothermia
  JOURNAL   J Cereb Blood Flow Metab 39 (7), 1349-1354 (2019)
   PUBMED   29466895
REFERENCE   2  (bases 1 to 2612)
  AUTHORS   Gupta,A.K., Chopra,B.S., Vaid,B., Sagar,A., Raut,S., Badmalia,M.D.,
            Ashish and Khatri,N.
  TITLE     Protective effects of gelsolin in acute pulmonary thromboembolism
            and thrombosis in the carotid artery of mice
  JOURNAL   PLoS One 14 (4), e0215717 (2019)
   PUBMED   31002695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2612)
  AUTHORS   Hu,W.S., Ting,W.J., Tamilselvi,S., Day,C.H., Wang,T., Chiang,W.D.,
            Viswanadha,V.P., Yeh,Y.L., Lin,W.T. and Huang,C.Y.
  TITLE     Oral administration of alcalase potato protein hydrolysate-APPH
            attenuates high fat diet-induced cardiac complications via
            TGF-beta/GSN axis in aging rats
  JOURNAL   Environ Toxicol 34 (1), 5-12 (2019)
   PUBMED   30240538
REFERENCE   4  (bases 1 to 2612)
  AUTHORS   Gertz,K., Uhlemann,R., Foryst-Ludwig,A., Barrientos,R.M.,
            Kappert,K., Thone-Reineke,C., Djoufack,P., Kirschbaum,C.,
            Fink,K.B., Heinz,A., Kintscher,U., Endres,M. and Kronenberg,G.
  TITLE     The cytoskeleton in 'couch potato-ism': Insights from a murine
            model of impaired actin dynamics
  JOURNAL   Exp Neurol 306, 34-44 (2018)
   PUBMED   29684438
REFERENCE   5  (bases 1 to 2612)
  AUTHORS   Segado-Arenas,A., Infante-Garcia,C., Benavente-Fernandez,I.,
            Sanchez-Sotano,D., Ramos-Rodriguez,J.J., Alonso-Ojembarrena,A.,
            Lubian-Lopez,S. and Garcia-Alloza,M.
  TITLE     Cognitive Impairment and Brain and Peripheral Alterations in a
            Murine Model of Intraventricular Hemorrhage in the Preterm Newborn
  JOURNAL   Mol Neurobiol 55 (6), 4896-4910 (2018)
   PUBMED   28755273
REFERENCE   6  (bases 1 to 2612)
  AUTHORS   Levy,E., Haltia,M., Fernandez-Madrid,I., Koivunen,O., Ghiso,J.,
            Prelli,F. and Frangione,B.
  TITLE     Mutation in gelsolin gene in Finnish hereditary amyloidosis
  JOURNAL   J Exp Med 172 (6), 1865-1867 (1990)
   PUBMED   2175344
REFERENCE   7  (bases 1 to 2612)
  AUTHORS   Chaponnier,C., Kocher,O. and Gabbiani,G.
  TITLE     Modulation of gelsolin content in rat aortic smooth muscle cells
            during development, experimental intimal thickening and culture. An
            immunohistochemical and biochemical study
  JOURNAL   Eur J Biochem 190 (3), 559-565 (1990)
   PUBMED   2164930
REFERENCE   8  (bases 1 to 2612)
  AUTHORS   Rabie,A., Ferraz,C., Clavel,M.C. and Legrand,C.
  TITLE     Gelsolin immunoreactivity and development of the tectorial membrane
            in the cochlea of normal and hypothyroid rats
  JOURNAL   Cell Tissue Res 254 (1), 241-245 (1988)
   PUBMED   2848627
REFERENCE   9  (bases 1 to 2612)
  AUTHORS   Smith,D.B., Janmey,P.A. and Lind,S.E.
  TITLE     Circulating actin-gelsolin complexes following oleic acid-induced
            lung injury
  JOURNAL   Am J Pathol 130 (2), 261-267 (1988)
   PUBMED   2829631
REFERENCE   10 (bases 1 to 2612)
  AUTHORS   Kwiatkowski,D.J., Stossel,T.P., Orkin,S.H., Mole,J.E., Colten,H.R.
            and Yin,H.L.
  TITLE     Plasma and cytoplasmic gelsolins are encoded by a single gene and
            contain a duplicated actin-binding domain
  JOURNAL   Nature 323 (6087), 455-458 (1986)
   PUBMED   3020431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079472.1.
            
            On Sep 3, 2004 this sequence version replaced XM_216043.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132271, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2612
                     /gene="Gsn"
                     /note="gelsolin"
                     /db_xref="GeneID:296654"
                     /db_xref="RGD:1303089"
     exon            1..148
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2353
                     /gene="Gsn"
                     /note="ADF; brevin; actin-depolymerizing factor"
                     /codon_start=1
                     /product="gelsolin precursor"
                     /protein_id="NP_001004080.1"
                     /db_xref="GeneID:296654"
                     /db_xref="RGD:1303089"
                     /translation="MAPYCSSLRSALLVLALCALSPSHAATASRGRAQERAPQSRVSE
                     TRPSTMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLR
                     NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESSTFQGYFK
                     SGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILDL
                     GNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVSEEGSEPEAMLQVLGPKP
                     DLPQGTEDTAKEDAANRRLAKLYKVSNSGGSMSVSLVADENPFAQSALRSEDCFILDH
                     GRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFK
                     NWRDPDQTDGPGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRI
                     EGSNKVLVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILT
                     AQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTTPASTRLFQV
                     RASSSGATRAVEVMPKAGALNSNDAFVLKTPSAAYLWVGTGASDAEKTGALELLKVLR
                     AQHVQVEEGSEPDGFWEALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEV
                     PGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRT
                     PITVVRQGFEPPSFVGWFLGWDDDYWSVDPLDRALAELAA"
     sig_peptide     11..85
                     /gene="Gsn"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     86..2350
                     /gene="Gsn"
                     /product="Gelsolin. /id=PRO_0000288477"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1)"
     misc_feature    92..154
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    161..532
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Actin-severing. /evidence=ECO:0000255"
     misc_feature    179..517
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S1_like; cd11290"
                     /db_xref="CDD:200446"
     misc_feature    179..517
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S1_like; cd11290"
                     /db_xref="CDD:200446"
     misc_feature    order(230..235,350..352,368..373,377..385,389..397,
                     401..406,437..439,443..445)
                     /gene="Gsn"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200446"
     misc_feature    order(230..235,350..352,368..373,377..385,389..397,
                     401..406,437..439,443..445)
                     /gene="Gsn"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200446"
     misc_feature    260..262
                     /gene="Gsn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     misc_feature    371..382
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Actin-actin interfilament contact point.
                     /evidence=ECO:0000250"
     misc_feature    560..829
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S2_like; cd11289"
                     /db_xref="CDD:200445"
     misc_feature    560..829
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S2_like; cd11289"
                     /db_xref="CDD:200445"
     misc_feature    596..814
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Gelsolin-like 2. /evidence=ECO:0000255"
     misc_feature    740..868
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    896..1189
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S3_like; cd11292"
                     /db_xref="CDD:200448"
     misc_feature    896..1189
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S3_like; cd11292"
                     /db_xref="CDD:200448"
     misc_feature    953..1171
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Gelsolin-like 3. /evidence=ECO:0000255"
     misc_feature    order(1172..1174,1187..1189)
                     /gene="Gsn"
                     /note="putative nucleotide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:200448"
     misc_feature    order(1172..1174,1187..1189)
                     /gene="Gsn"
                     /note="putative nucleotide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:200448"
     misc_feature    1229..1231
                     /gene="Gsn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     misc_feature    1304..2350
                     /gene="Gsn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68FP1.1);
                     Region: Actin-binding, Ca-sensitive.
                     /evidence=ECO:0000255"
     misc_feature    1319..1621
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S4_like; cd11293"
                     /db_xref="CDD:200449"
     misc_feature    1319..1621
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S4_like; cd11293"
                     /db_xref="CDD:200449"
     misc_feature    order(1367..1372,1484..1486,1502..1507,1511..1519,
                     1523..1531,1535..1540,1571..1573,1577..1579)
                     /gene="Gsn"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    order(1367..1372,1484..1486,1502..1507,1511..1519,
                     1523..1531,1535..1540,1571..1573,1577..1579)
                     /gene="Gsn"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    1397..1399
                     /gene="Gsn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     misc_feature    1592..1594
                     /gene="Gsn"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    1592..1594
                     /gene="Gsn"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    1685..1951
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S5_like; cd11288"
                     /db_xref="CDD:200444"
     misc_feature    1685..1951
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S5_like; cd11288"
                     /db_xref="CDD:200444"
     misc_feature    1709..1711
                     /gene="Gsn"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200444"
     misc_feature    1709..1711
                     /gene="Gsn"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200444"
     misc_feature    1754..1756
                     /gene="Gsn"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P13020; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); acetylation site"
     misc_feature    1811..1813
                     /gene="Gsn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     misc_feature    1955..1957
                     /gene="Gsn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     misc_feature    2000..2296
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S6_like; cd11291"
                     /db_xref="CDD:200447"
     misc_feature    2000..2296
                     /gene="Gsn"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S6_like; cd11291"
                     /db_xref="CDD:200447"
     misc_feature    2228..2230
                     /gene="Gsn"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P06396; propagated from
                     UniProtKB/Swiss-Prot (Q68FP1.1); phosphorylation site"
     exon            149..353
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            354..508
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            509..670
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            671..820
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            821..910
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1043
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1132
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1348
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1482
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1573
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1744
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1919
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2044
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2122
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2183
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2582
                     /gene="Gsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgtcacc atggctccgt attgctcctc gctgcgctct gcgctgctcg tcctggcgct
       61 gtgcgcactg tcgccgtccc atgcagccac cgcatcgcgg ggcagggccc aagagagggc
      121 gccccaaagt cgggtgtctg agacgcggcc cagcaccatg gtggtggagc accccgaatt
      181 cctgaaggca gggaaggagc ctggcctgca gatctggcgt gtggagaagt ttgacctggt
      241 gcctgtgccc cccaacctct atggagactt cttcacgggt gacgcctatg tcatcctaaa
      301 gacggtgcag ctgaggaatg ggaatctgca gtatgacctc cactattggc tgggcaacga
      361 gtgcagccag gacgagagcg gggctgccgc catctttacc gtgcagctgg atgactacct
      421 gaatggccgg gctgtacagc accgtgaggt tcagggcttt gagtcgtcca cattccaagg
      481 ctacttcaag tctggactta agtacaagaa aggaggcgtg gcatctggat tcaaacacgt
      541 ggtacccaac gaggtggtgg tgcagaggct cttccaggtc aagggacgcc gtgtagtccg
      601 tgccactgaa gtacctgtgt cctgggacag tttcaacaac ggtgactgct tcattctgga
      661 cctgggaaat aatatctatc agtggtgtgg ctccggcagc aacaagtttg aaagactgaa
      721 ggccacgcag gtgtccaagg gcatccggga caacgagagg agtggacgcg cccaagtaca
      781 tgtgtctgaa gagggtagcg agccggaagc catgctccag gtgctgggcc ccaagccgga
      841 tctgcctcag ggcaccgagg acacagccaa ggaagatgct gccaaccgaa ggctggccaa
      901 gctctacaag gtctccaaca gtggaggcag catgtcagtc tccctcgtgg ctgacgagaa
      961 ccccttcgcc cagtccgccc tgagatccga ggactgtttc atcctggacc acggcagaga
     1021 tgggaaaatc tttgtttgga aaggcaagca ggccaacatg gatgagcgga aggctgccct
     1081 caaaacagcc tctgacttca tctccaagat gcagtacccc aggcagaccc aggtttcagt
     1141 cctcccggag ggcggcgaga ctcctctctt taagcagttc ttcaagaact ggcgggaccc
     1201 agaccagaca gacggccctg gcctgagcta cctctccagc cacattgcca acgtggagcg
     1261 cgtgcctttc gatgctgcta cactgcacac ctccactgcc atggctgccc agcacggcat
     1321 ggatgatgac ggaactggcc agaaacagat ctggagaatt gaaggttcca acaaggtact
     1381 ggtggacccc gccacatatg gccagttcta tggaggtgac agctacatca ttctgtacaa
     1441 ctaccgccat ggtggccgcc agggacagat catctacaac tggcagggtg cccagtctac
     1501 ccaggatgag gtcgctgctt cagccatcct gactgcccag ctggatgagg aactgggagg
     1561 aactcctgtc cagagccgag tggtccaagg caaagagcct gcacacctca tgagcttgtt
     1621 tggtgggaag cccatgatca tctacaaggg cggcacctcc cgagatggtg ggcagacaac
     1681 ccctgccagt acccgcctct tccaagtccg ggccagcagc tctggagcca ccagggctgt
     1741 tgaggtaatg cctaaggctg gcgctctcaa ctccaatgat gcctttgtgc tgaaaacccc
     1801 ctccgccgcc tacctgtggg tgggtacagg agccagtgat gcggagaaga ccggcgccct
     1861 ggagctgctg aaggtgctga gggcccagca cgtgcaggtg gaggaaggca gtgaaccaga
     1921 tggcttctgg gaggctctgg gcgggaagac tgcctaccgc acatccccca ggcttaagga
     1981 caagaagatg gatgctcatc ctcctcgcct cttcgcctgc tccaacagga tcgggcgctt
     2041 tgtgatcgaa gaggttcctg gcgagcttat gcaggaagac ctggctactg atgacgtcat
     2101 gctcctggac acctgggacc aggtctttgt ctgggttgga aaggactctc aggaagagga
     2161 aaagacagaa gccttgacct ctgctaagcg gtacatcgag acggacccag cgaatcggga
     2221 caggcggacc cccatcactg tcgttaggca aggctttgag cctccttcct ttgtgggctg
     2281 gttcctcggc tgggatgatg actactggtc ggtggatccc ttggaccggg ccttggctga
     2341 gctggctgcc tgagtaagga ccagagctac caatgtcacc aatcagtgcc tttgagggtt
     2401 gtccatctcc cagagagatc ctatgacaag caggaaaact atagtgtgtg tgcacgtgtt
     2461 tttgtttgtt tgtttttttt tacgatagcc aaaacaagcc ctgtgaaaac tcagggtctt
     2521 tgcagaattg cttcaagtat ctgtactttg gaaataaaac ccaataaaag cttttcgaag
     2581 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
LOCUS       NM_001012044            3436 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus lymphocyte cytosolic protein 1 (Lcp1), mRNA.
ACCESSION   NM_001012044 XM_224406
VERSION     NM_001012044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Zhang,W., Xu,L., Yu,Z., Zhang,M., Liu,J. and Zhou,J.
  TITLE     Inhibition of the Glycolysis Prevents the Cerebral Infarction
            Progression Through Decreasing the Lactylation Levels of LCP1
  JOURNAL   Mol Biotechnol 65 (8), 1336-1345 (2023)
   PUBMED   36574182
  REMARK    GeneRIF: Inhibition of the Glycolysis Prevents the Cerebral
            Infarction Progression Through Decreasing the Lactylation Levels of
            LCP1.
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Forster,F., Paster,W., Supper,V., Schatzlmaier,P., Sunzenauer,S.,
            Ostler,N., Saliba,A., Eckerstorfer,P., Britzen-Laurent,N.,
            Schutz,G., Schmid,J.A., Zlabinger,G.J., Naschberger,E., Sturzl,M.
            and Stockinger,H.
  TITLE     Guanylate binding protein 1-mediated interaction of T cell antigen
            receptor signaling with the cytoskeleton
  JOURNAL   J Immunol 192 (2), 771-781 (2014)
   PUBMED   24337748
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Choi,J.H., Lee,M.Y., Ramakrishna,S., Kim,Y., Shim,J.Y., Han,S.M.,
            Kim,J.Y., Lee,D.H., Choi,Y.K. and Baek,K.H.
  TITLE     LCP1 up-regulated by partial pancreatectomy supports cell
            proliferation and differentiation
  JOURNAL   Mol Biosyst 7 (11), 3104-3111 (2011)
   PUBMED   21922118
  REMARK    GeneRIF: the LCP1 may play a critical role in the pancreas
            regeneration.
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   Ohsawa,K., Imai,Y., Sasaki,Y. and Kohsaka,S.
  TITLE     Microglia/macrophage-specific protein Iba1 binds to fimbrin and
            enhances its actin-bundling activity
  JOURNAL   J Neurochem 88 (4), 844-856 (2004)
   PUBMED   14756805
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Zu,Y., Kohno,M., Kubota,I., Nishida,E., Hanaoka,M. and Namba,Y.
  TITLE     Characterization of interleukin 2 stimulated 65-kilodalton
            phosphoprotein in human T cells
  JOURNAL   Biochemistry 29 (4), 1055-1062 (1990)
   PUBMED   2111166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083855.1.
            
            On Feb 11, 2005 this sequence version replaced XM_224406.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132303
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..3436
                     /gene="Lcp1"
                     /note="lymphocyte cytosolic protein 1"
                     /db_xref="GeneID:306071"
                     /db_xref="RGD:1308288"
     exon            1..22
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            23..109
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1929
                     /gene="Lcp1"
                     /codon_start=1
                     /product="plastin-2"
                     /protein_id="NP_001012044.1"
                     /db_xref="GeneID:306071"
                     /db_xref="RGD:1308288"
                     /translation="MARGSVSDEEMMELREAFAKVDTDGNGYISCNELNDLFKAACLP
                     LPGYRVREITENLMATGDLDQDGKISFDEFIKVFHGLKSTEVAKTFRKAINKKEGICA
                     IGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDG
                     IVLCKMVNLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKE
                     GKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANY
                     HLENAGCTKITNFSTDIKDSKAYYHLLEQVAPRGDEEGIPAVVIDMSGLREKDDIQRA
                     ECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEG
                     ETREERTFRNWMNSLGVNPGVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNRPPYPKL
                     GGNMKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILE
                     DIGGGQKVNDDIIVNWVNTTLKEAQKSSSITSFKDPKISTSLPVLDLIDAIQPGSINY
                     DLLKTENLDDEEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGM
                     KRV"
     misc_feature    82..282
                     /gene="Lcp1"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     Region: EFh; cd00051"
                     /db_xref="CDD:238008"
     misc_feature    82..282
                     /gene="Lcp1"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     Region: EFh; cd00051"
                     /db_xref="CDD:238008"
     misc_feature    order(109..111,115..117,121..123,142..144,229..231,
                     235..237,241..243,262..264)
                     /gene="Lcp1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238008"
     misc_feature    order(109..111,115..117,121..123,142..144,229..231,
                     235..237,241..243,262..264)
                     /gene="Lcp1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238008"
     misc_feature    337..771
                     /gene="Lcp1"
                     /note="first calponin homology (CH) domain found in the
                     plastin family; Region: CH_PLS_rpt1; cd21292"
                     /db_xref="CDD:409141"
     misc_feature    337..771
                     /gene="Lcp1"
                     /note="first calponin homology (CH) domain found in the
                     plastin family; Region: CH_PLS_rpt1; cd21292"
                     /db_xref="CDD:409141"
     misc_feature    order(409..411,421..423,610..612,616..621,628..633,
                     637..639,664..690,703..705,709..714,718..723,730..735,
                     742..744)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409141"
     misc_feature    order(409..411,421..423,610..612,616..621,628..633,
                     637..639,664..690,703..705,709..714,718..723,730..735,
                     742..744)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409141"
     misc_feature    796..1170
                     /gene="Lcp1"
                     /note="second calponin homology (CH) domain found in
                     plastin-2; Region: CH_PLS2_rpt2; cd21327"
                     /db_xref="CDD:409176"
     misc_feature    796..1170
                     /gene="Lcp1"
                     /note="second calponin homology (CH) domain found in
                     plastin-2; Region: CH_PLS2_rpt2; cd21327"
                     /db_xref="CDD:409176"
     misc_feature    order(841..843,853..855,1030..1032,1036..1041,1048..1053,
                     1057..1059,1081..1107,1120..1122,1126..1131,1135..1140,
                     1147..1152,1159..1161)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409176"
     misc_feature    order(841..843,853..855,1030..1032,1036..1041,1048..1053,
                     1057..1059,1081..1107,1120..1122,1126..1131,1135..1140,
                     1147..1152,1159..1161)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409176"
     misc_feature    1165..1566
                     /gene="Lcp1"
                     /note="calponin homology (CH) domain superfamily; Region:
                     CH_SF; cl00030"
                     /db_xref="CDD:469584"
     misc_feature    1165..1566
                     /gene="Lcp1"
                     /note="calponin homology (CH) domain superfamily; Region:
                     CH_SF; cl00030"
                     /db_xref="CDD:469584"
     misc_feature    order(1243..1245,1408..1410,1414..1419,1426..1431,
                     1435..1437,1477..1491,1504..1506,1510..1515,1519..1524,
                     1531..1536,1543..1545)
                     /gene="Lcp1"
                     /note="actin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409180"
     misc_feature    order(1243..1245,1408..1410,1414..1419,1426..1431,
                     1435..1437,1477..1491,1504..1506,1510..1515,1519..1524,
                     1531..1536,1543..1545)
                     /gene="Lcp1"
                     /note="actin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409180"
     misc_feature    1576..1920
                     /gene="Lcp1"
                     /note="fourth calponin homology (CH) domain found in
                     plastin-2; Region: CH_PLS2_rpt4; cd21333"
                     /db_xref="CDD:409182"
     misc_feature    1576..1920
                     /gene="Lcp1"
                     /note="fourth calponin homology (CH) domain found in
                     plastin-2; Region: CH_PLS2_rpt4; cd21333"
                     /db_xref="CDD:409182"
     misc_feature    order(1594..1596,1606..1608,1777..1779,1783..1788,
                     1795..1800,1804..1806,1828..1854,1867..1869,1873..1878,
                     1882..1887,1894..1899,1906..1908)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409182"
     misc_feature    order(1594..1596,1606..1608,1777..1779,1783..1788,
                     1795..1800,1804..1806,1828..1854,1867..1869,1873..1878,
                     1882..1887,1894..1899,1906..1908)
                     /gene="Lcp1"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409182"
     exon            110..273
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..403
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..536
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..618
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..784
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..927
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1219
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1298
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1413
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1547
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1671
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1796
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..3407
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgaggacag tgtctctaca aggtctgtca cctaaagcag tcaaaatggc cagaggatcc
       61 gtgtctgatg aagaaatgat ggagctcaga gaggcttttg ccaaagtcga tactgacggc
      121 aacgggtaca tcagctgcaa tgaactgaat gacttgttca aggcggcctg cctgcctctg
      181 cctggctacc gagtgagaga aatcacagag aacctgatgg ccacaggtga cctggaccaa
      241 gatgggaaga ttagctttga tgagtttatc aaggtcttcc atggcttaaa aagcaccgag
      301 gttgccaaaa ccttccgaaa agctatcaac aagaaggaag ggatctgtgc gatcggtggc
      361 acctctgagc agtccagcgt gggtacccag cattcctact cagaggaaga aaagtatgcc
      421 tttgtcaact ggataaacaa agccctggag aatgaccctg actgccggca cgtcatcccc
      481 atgaacccga acaccgatga tctcttcaat gctgtcgggg atggcatagt tctttgtaaa
      541 atggtcaacc tgtctgtgcc agacacaatt gatgaaagaa caatcaacaa gaagaagctc
      601 acaccgttca ccattcagga aaacttgaac ttagctctga actctgcctc ggccatcgga
      661 tgccatgtag ttaatatagg ggctgaggac ctgaaggagg ggaagccata tctggtcctg
      721 ggacttttgt ggcaagttat caagattggg ttgtttgctg acattgaact cagcagaaat
      781 gaagctctga ttgctctttt gagagaagga gagagcctag aggatttgat gaagttgtct
      841 cctgaagaac tcctgttgcg gtgggcgaac taccacctag aaaatgcagg ctgcaccaaa
      901 atcaccaact tcagcactga catcaaggac tcgaaagctt attaccacct gctcgagcag
      961 gtggctccga gaggagatga agaagggatc ccggctgtag tgattgacat gtcaggactg
     1021 agggagaagg atgacatcca gagagcagag tgtatgttgc agcaggcaga gaggctgggc
     1081 tgccggcagt ttgtcacagc cactgatgtt gtccgaggga accccaagtt gaacctggcc
     1141 ttcattgcca acctctttaa caaataccct gccttgcaca aaccggagaa ccaggacatt
     1201 gactgggggg ctctcgaagg tgagacgagg gaagagcgga cgttcaggaa ctggatgaac
     1261 tcactgggag ttaaccctgg agtcaatcat ttgtacagcg acttatccga cgccctggtc
     1321 atcttccagc tctatgaaaa gatcaaagtc cctgttgact ggaacagagt aaacagacct
     1381 ccatacccca agctgggggg caacatgaaa aagctcgaga actgtaatta tgcagtggat
     1441 ctggggaaga atcaagctaa attttcccta gttggtatcg caggacaaga cctcaatgaa
     1501 ggaaaccgca ctctgacgct ggcattggtt tggcagctca tgagaaggta cacactgaat
     1561 atcctggaag atattggagg tggtcagaag gtcaatgatg acattattgt caactgggtg
     1621 aacacgacat tgaaggaggc acagaaaagt tcgtccatca ctagcttcaa ggacccaaag
     1681 atcagcacca gcctcccggt tctggatctc atcgatgcca ttcagccagg ctccataaac
     1741 tatgaccttc tgaagacaga aaacctggat gatgaagaga agctcaacaa tgcaaagtat
     1801 gctatctcca tggccagaaa aatcggagca agagtgtatg cccttccaga agacctggtt
     1861 gaagtgaacc ccaaaatggt catgacagtg ttcgcttgcc tcatggggaa agggatgaag
     1921 agggtgtaag tcccacagga gcaagccaga aagagacacc atcaaccctg agggtcagca
     1981 tgtgatgctc ccaggataca gaggaccatt caagccattc caaagtcctg aaccttggag
     2041 acattgtctg aaattcgcat atttgttctg ccaagtagct tctgctatag tcgagcttct
     2101 cttttgttgt ccccaccccc aggagatcta ctcgcctaca gatttttttc ttttattctt
     2161 tgaaattctt tgggggaggg gggagagtta aaaagaagtt atttccagat gctcacccca
     2221 cccccgacac ccttgctttc actgatagcc aaggatatag actacattgt tcttaagggt
     2281 cacctgatct cttgagccag tttgatctag ctgctttttg ccttgttcaa actgaggacc
     2341 tggaagggat cgtcaaactt gccttaaata aagcctgtca ctagaggctg acactggatg
     2401 gtcacagccc ttccttgcat ctcctctcag cttgtctccc tgtgagtttg ctccaatccc
     2461 ctcagaacca tacctgctct gtggtcccca tttttgccag ccttgtctct aggctactgg
     2521 agtatctgac aaatcagtca agctcccagg agtctctggg agactgaaaa actggggtct
     2581 caaagaaagt gtaatggaga gtaaaaccac tagggggcag tatggtggga ccacaaagca
     2641 tctacccttc tgtgtatatc tccacacctt taactcctct tgttagagag ctgcttattg
     2701 tggtgttgac aaaatgtctg atgacagttg gaagcaatcc tgcataactt catttgcttt
     2761 tagacatcga catatttgat tgtcaccagg ccatattacc aatactcact ttgttggtac
     2821 tataaaagct tttgcctccc taaagtttct gtaagtgggg ggttgatatg tgccaataat
     2881 ctatgtccct gcctcaccca aatgcttgca cgggcacata cgcatatgta gctggatgcc
     2941 aagagtacca tgttgactag gaactgcctg gaattcaaaa cagaaaaggg acagcatgaa
     3001 tttgaatagc tcccactaga taagcaattt ccacgaaaac ttaccaaaag ctaaaactcc
     3061 acagagcatt gtgaaccaaa ggtagactcc ctttgcatta gtgaaagtct tactcccact
     3121 aatgggactt cgttgtcttc caaagcagtg gaaatgcagg atctcaactt catcccctga
     3181 cagtgggctc aggaaaccaa tagatggctc tttccagctc ccaaccagta ttcccgctgc
     3241 atccgaatgc aaagtgtttg gctgtgactt tagtctgaac atcatgtagc ctcagatgat
     3301 gtttgcccat ctgcctccac gaagtaagga tattattgtt gccttaatgg aaaaatgaag
     3361 ataaatcatg tttaaaaaaa tctttccaaa taaaatgttc ccaattcaaa aaaaaaaaaa
     3421 aaaaaaaaaa aaaaaa
//
LOCUS       NM_001013086            1500 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein, gelsolin like (Capg),
            mRNA.
ACCESSION   NM_001013086 XM_216166
VERSION     NM_001013086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Hubert,T., Van Impe,K., Vandekerckhove,J. and Gettemans,J.
  TITLE     The actin-capping protein CapG localizes to microtubule-dependent
            organelles during the cell cycle
  JOURNAL   Biochem Biophys Res Commun 380 (1), 166-170 (2009)
   PUBMED   19166812
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Hubert,T., Van Impe,K., Vandekerckhove,J. and Gettemans,J.
  TITLE     The F-actin filament capping protein CapG is a bona fide nucleolar
            protein
  JOURNAL   Biochem Biophys Res Commun 377 (2), 699-704 (2008)
   PUBMED   18938132
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Van Impe,K., Hubert,T., De Corte,V., Vanloo,B., Boucherie,C.,
            Vandekerckhove,J. and Gettemans,J.
  TITLE     A new role for nuclear transport factor 2 and Ran: nuclear import
            of CapG
  JOURNAL   Traffic 9 (5), 695-707 (2008)
   PUBMED   18266911
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Witke,W., Li,W., Kwiatkowski,D.J. and Southwick,F.S.
  TITLE     Comparisons of CapG and gelsolin-null macrophages: demonstration of
            a unique role for CapG in receptor-mediated ruffling, phagocytosis,
            and vesicle rocketing
  JOURNAL   J Cell Biol 154 (4), 775-784 (2001)
   PUBMED   11514591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079104.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216166.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079104.1, SRR8487230.30007.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1500
                     /gene="Capg"
                     /note="capping actin protein, gelsolin like"
                     /db_xref="GeneID:297339"
                     /db_xref="RGD:1311724"
     exon            1..292
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    264..266
                     /gene="Capg"
                     /note="upstream in-frame stop codon"
     exon            293..328
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1355
                     /gene="Capg"
                     /note="actin regulatory protein CAP-G; capping protein
                     (actin filament), gelsolin-like"
                     /codon_start=1
                     /product="macrophage-capping protein"
                     /protein_id="NP_001013104.1"
                     /db_xref="GeneID:297339"
                     /db_xref="RGD:1311724"
                     /translation="MYTPIPQSGSPFPASVQDPGLHIWRVEKLKPVPIARENHGIFFS
                     GDSYLVLHNGPEEASHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNE
                     SDLFMSYFPQGLKYREGGVESAFHKTTSGTTPAAIRKLYQVKGKKNIRATERALSWDS
                     FNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIITDGEEP
                     AEMIQVLGPKPALKEGNPEEDITADQTNAQAAALYKVSDATGQMNLTKVADSSPFASE
                     LLIPDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVADGFISRMRYSPNTQVEILPQ
                     GRESPIFKQFFKDWK"
     misc_feature    306..308
                     /gene="Capg"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P40121; propagated from
                     UniProtKB/Swiss-Prot (Q6AYC4.1); acetylation site"
     misc_feature    354..665
                     /gene="Capg"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S1_like; cd11290"
                     /db_xref="CDD:200446"
     misc_feature    354..665
                     /gene="Capg"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S1_like; cd11290"
                     /db_xref="CDD:200446"
     misc_feature    387..626
                     /gene="Capg"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYC4.1);
                     Region: Gelsolin-like 1"
     misc_feature    order(390..395,498..500,516..521,525..533,537..545,
                     549..554,585..587,591..593)
                     /gene="Capg"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200446"
     misc_feature    order(390..395,498..500,516..521,525..533,537..545,
                     549..554,585..587,591..593)
                     /gene="Capg"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200446"
     misc_feature    717..746
                     /gene="Capg"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYC4.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    720..983
                     /gene="Capg"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S2_like; cd11289"
                     /db_xref="CDD:200445"
     misc_feature    720..983
                     /gene="Capg"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S2_like; cd11289"
                     /db_xref="CDD:200445"
     misc_feature    744..971
                     /gene="Capg"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYC4.1);
                     Region: Gelsolin-like 2"
     misc_feature    1044..1346
                     /gene="Capg"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S3_like; cd11292"
                     /db_xref="CDD:200448"
     misc_feature    1044..1346
                     /gene="Capg"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S3_like; cd11292"
                     /db_xref="CDD:200448"
     misc_feature    1095..1331
                     /gene="Capg"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYC4.1);
                     Region: Gelsolin-like 3"
     misc_feature    1317..1319
                     /gene="Capg"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6AYC4.1); phosphorylation site"
     misc_feature    order(1329..1331,1344..1346)
                     /gene="Capg"
                     /note="putative nucleotide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:200448"
     misc_feature    order(1329..1331,1344..1346)
                     /gene="Capg"
                     /note="putative nucleotide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:200448"
     exon            329..501
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            502..656
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            657..824
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            825..974
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1067
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1200
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1477
                     /gene="Capg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctttcc ttgcccatct gactttaaat tgctcagaat ttgccttgcc tgaggctgct
       61 gtgatgagac cctgtcaggc tttaaccttc cagtggtcgt gtccgggaaa gggcagtctt
      121 ccatcagcat ggctcagtct tggagcttgc tttccagaat cttagacctc tgagttctga
      181 gcctccccat gggtggggca ggtgggcggg acagcccagt ggagaagagg gaagtcagaa
      241 gccagcgtgg ggcaggctga gactagtcgg agaagaaaag gccggtggag aggtctgaaa
      301 acagcatgta cacgcccatc cctcagagtg gctctccatt cccagcctca gtccaagacc
      361 caggcctaca catatggcgt gtggagaagc tgaagccggt gcccatagca cgagagaacc
      421 atggcatctt tttttctggg gattcctacc tagtgcttca caatggcccg gaagaggcct
      481 cccatctgca cctgtggata ggccagcagt catcgcgcga tgagcagggg gcctgcgctg
      541 tgctagctgt gcacctcaac accctgctgg gggagcggcc tgtgcagcac cgtgaggttc
      601 aagggaacga gtccgacctc ttcatgagct acttcccaca aggcctcaag tatcgggagg
      661 gtggcgtgga gtcggcgttc cacaagacaa cctcgggcac cacgccagca gccatcagga
      721 agctctacca ggttaagggg aagaagaaca tccgtgcgac cgagagggct ctgagctggg
      781 acagcttcaa cactggggac tgcttcatcc tggacctggg tcagaacatc tttgcctggt
      841 gtggtggcaa gtccaacatc ctggagcgca acaaggcgag agacctggcc ctggccatcc
      901 gggacagcga gcggcagggg aaggcccagg tggagatcat cactgacgga gaggagccag
      961 ccgagatgat ccaggttctg ggccccaagc ctgctctgaa ggagggcaac cctgaggagg
     1021 acattacagc ggaccagacc aacgcccagg ctgcagccct gtataaggtc tctgatgcca
     1081 ctggacagat gaatctgacc aaggtggctg actccagccc gtttgcctct gaactgctaa
     1141 ttccagatga ctgctttgtt ctggacaacg ggctatgtgg caaaatctac atctggaagg
     1201 ggagaaaagc caatgagaag gagcggcagg cggccctcca agtggctgat ggcttcatct
     1261 ctcgaatgag atattcccca aacactcagg tggagattct gccccagggc cgagagagtc
     1321 ccatcttcaa gcagttcttc aaggactgga agtgagggtg ggtgtcccca tccctgctct
     1381 cctgccccca ccacctgcct gcttgtttcc cctctggctg ctgagtcaga actgaggggc
     1441 cctctggatg ctcaataaag gacacgttct gttcccaaaa aaaaaaaaaa aaaaaaaaaa
//
LOCUS       NM_031054               3053 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA.
ACCESSION   NM_031054
VERSION     NM_031054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Wang,C., Xu,Y., Xu,M., Sun,C., Zhang,X., Tao,X. and Song,T.
  TITLE     SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to
            regulate astrocytic MMP-2 activation in rats with chronic
            constriction injury
  JOURNAL   J Neuroinflammation 21 (1), 57 (2024)
   PUBMED   38388415
  REMARK    GeneRIF: SPOCK2 modulates neuropathic pain by interacting with
            MT1-MMP to regulate astrocytic MMP-2 activation in rats with
            chronic constriction injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Hirata,T., Fan,F., Fan,L., Amin,G., White,T., Geurts,A.M.,
            Kojima,N., Takahashi,T., Miyata,N., Williams,J. and Roman,R.J.
  TITLE     Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and
            Diabetes-induced Nephropathy
  JOURNAL   J Cardiovasc Pharmacol 82 (6), 445-457 (2023)
   PUBMED   37643020
  REMARK    GeneRIF: Knockout of Matrix Metalloproteinase 2 Opposes
            Hypertension- and Diabetes-induced Nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Zhu,X., Tang,Z., Li,W., Li,X., Iwakiri,Y. and Liu,F.
  TITLE     S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP
            activity in liver fibrosis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1640-1649 (2023)
   PUBMED   37700592
  REMARK    GeneRIF: S-nitrosylation of EMMPRIN influences the migration of
            HSCs and MMP activity in liver fibrosis.
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   de Oliveira Neves,V.G., Blascke de Mello,M.M., Rodrigues,D.,
            Pernomian,L., de Oliveira,I.S., Parente,J.M., Arantes,E.C.,
            Tostes,R.C. and Castro,M.M.
  TITLE     Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension
  JOURNAL   Vascul Pharmacol 152, 107211 (2023)
   PUBMED   37607602
  REMARK    GeneRIF: Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension.
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Hu,C., Jing,R., Wen,C., Qi,T., Bai,X., Wang,Y., Shao,Y. and Pei,C.
  TITLE     HNF4A Negatively Regulated Posterior Capsular Opacification via
            Transcriptional Inhibition of MMP2
  JOURNAL   Curr Eye Res 48 (7), 627-638 (2023)
   PUBMED   36988559
  REMARK    GeneRIF: HNF4A Negatively Regulated Posterior Capsular
            Opacification via Transcriptional Inhibition of MMP2.
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Harendza,S., Pollock,A.S., Mertens,P.R. and Lovett,D.H.
  TITLE     Tissue-specific enhancer-promoter interactions regulate high level
            constitutive expression of matrix metalloproteinase 2 by glomerular
            mesangial cells
  JOURNAL   J Biol Chem 270 (32), 18786-18796 (1995)
   PUBMED   7642529
REFERENCE   7  (bases 1 to 3053)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Lerch,M.M., Friess,H., Buchler,M.
            and Adler,G.
  TITLE     Expression and in-situ localization of genes coding for
            extracellular matrix proteins and extracellular matrix degrading
            proteases in pancreatic cancer
  JOURNAL   Int J Cancer 62 (4), 407-413 (1995)
   PUBMED   7635566
REFERENCE   8  (bases 1 to 3053)
  AUTHORS   Nakano,A., Tani,E., Miyazaki,K., Yamamoto,Y. and Furuyama,J.
  TITLE     Matrix metalloproteinases and tissue inhibitors of
            metalloproteinases in human gliomas
  JOURNAL   J Neurosurg 83 (2), 298-307 (1995)
   PUBMED   7616276
REFERENCE   9  (bases 1 to 3053)
  AUTHORS   Cleutjens,J.P., Kandala,J.C., Guarda,E., Guntaka,R.V. and
            Weber,K.T.
  TITLE     Regulation of collagen degradation in the rat myocardium after
            infarction
  JOURNAL   J Mol Cell Cardiol 27 (6), 1281-1292 (1995)
   PUBMED   8531210
REFERENCE   10 (bases 1 to 3053)
  AUTHORS   Marti,H.P., McNeil,L., Davies,M., Martin,J. and Lovett,D.H.
  TITLE     Homology cloning of rat 72 kDa type IV collagenase: cytokine and
            second-messenger inducibility in glomerular mesangial cells
  JOURNAL   Biochem J 291 (Pt 2) (Pt 2), 441-446 (1993)
   PUBMED   7916617
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U65656.1.
            
            On May 4, 2007 this sequence version replaced NM_031054.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65656.1, BC074013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093044, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3053
                     /gene="Mmp2"
                     /note="matrix metallopeptidase 2"
                     /db_xref="GeneID:81686"
                     /db_xref="RGD:621316"
     exon            1..444
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="Mmp2"
                     /note="upstream in-frame stop codon"
     CDS             292..2280
                     /gene="Mmp2"
                     /EC_number="3.4.24.24"
                     /note="72 KDa type IV collagenase; MMP-2; 72 kDa
                     gelatinase; matrix metalloproteinase-2; gelatinase A"
                     /codon_start=1
                     /product="72 kDa type IV collagenase precursor"
                     /protein_id="NP_112316.2"
                     /db_xref="GeneID:81686"
                     /db_xref="RGD:621316"
                     /translation="MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPK
                     TDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC
                     GNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFS
                     RIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEG
                     QVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH
                     EALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE
                     TAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPD
                     QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPD
                     ADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGP
                     LLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPD
                     VQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVD
                     LQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC"
     sig_peptide     292..378
                     /gene="Mmp2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <499..582
                     /gene="Mmp2"
                     /note="Putative peptidoglycan binding domain; Region:
                     PG_binding_1; pfam01471"
                     /db_xref="CDD:460223"
     misc_feature    <499..582
                     /gene="Mmp2"
                     /note="Putative peptidoglycan binding domain; Region:
                     PG_binding_1; pfam01471"
                     /db_xref="CDD:460223"
     misc_feature    589..612
                     /gene="Mmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2);
                     Region: Cysteine switch. /evidence=ECO:0000250"
     mat_peptide     619..2277
                     /gene="Mmp2"
                     /product="72 kDa type IV collagenase. /id=PRO_0000028721"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2)"
     misc_feature    619..954
                     /gene="Mmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2);
                     Region: Collagenase-like 1"
     misc_feature    643..1629
                     /gene="Mmp2"
                     /note="Matrixin; Region: Peptidase_M10; pfam00413"
                     /db_xref="CDD:425668"
     misc_feature    643..1629
                     /gene="Mmp2"
                     /note="Matrixin; Region: Peptidase_M10; pfam00413"
                     /db_xref="CDD:425668"
     misc_feature    955..1479
                     /gene="Mmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2);
                     Region: Collagen-binding"
     misc_feature    967..1113
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    967..1113
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    order(1000..1002,1006..1008,1021..1023,1063..1065,
                     1084..1086,1102..1104,1108..1110)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    order(1000..1002,1006..1008,1021..1023,1063..1065,
                     1084..1086,1102..1104,1108..1110)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    1141..1287
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    1141..1287
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    order(1174..1176,1180..1182,1195..1197,1237..1239,
                     1258..1260,1276..1278,1282..1284)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    order(1174..1176,1180..1182,1195..1197,1237..1239,
                     1258..1260,1276..1278,1282..1284)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    1315..1461
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    1315..1461
                     /gene="Mmp2"
                     /note="Fibronectin type 2 domain; Region: FN2; smart00059"
                     /db_xref="CDD:128373"
     misc_feature    order(1348..1350,1354..1356,1369..1371,1411..1413,
                     1432..1434,1450..1452,1456..1458)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    order(1348..1350,1354..1356,1369..1371,1411..1413,
                     1432..1434,1450..1452,1456..1458)
                     /gene="Mmp2"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     misc_feature    1480..1692
                     /gene="Mmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2);
                     Region: Collagenase-like 2"
     misc_feature    1531..2277
                     /gene="Mmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P33436.2);
                     Region: Required for inhibitor TIMP2 binding.
                     /evidence=ECO:0000250"
     misc_feature    1693..2277
                     /gene="Mmp2"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     Region: HX; cd00094"
                     /db_xref="CDD:238046"
     misc_feature    1693..2277
                     /gene="Mmp2"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     Region: HX; cd00094"
                     /db_xref="CDD:238046"
     misc_feature    order(1723..1725,1729..1731,1858..1860,1864..1866,
                     2002..2004,2008..2010,2149..2151,2155..2157)
                     /gene="Mmp2"
                     /note="Metal binding sites [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238046"
     misc_feature    order(1723..1725,1729..1731,1858..1860,1864..1866,
                     2002..2004,2008..2010,2149..2151,2155..2157)
                     /gene="Mmp2"
                     /note="Metal binding sites [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238046"
     misc_feature    2014..2016
                     /gene="Mmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33436.2); glycosylation site"
     misc_feature    2221..2223
                     /gene="Mmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33436.2); glycosylation site"
     exon            445..671
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..820
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..949
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1123
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1297
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1471
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1627
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1769
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1906
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2066
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2176
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..3040
                     /gene="Mmp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcgtctg cccgcccttg tttccgctgc atccagactt ccccgggtgg ctggaggctc
       61 tgtgtgcatc cagaacttta gatatacaaa gggattacta ggacctgcaa gcacccgcag
      121 ccgtggtgcg tactggtacg tgggatcccg ttatgagacc ctgagcccgg agaagctgag
      181 gcaattgagt aaaggggtct cagaacgccg tggagagcag gcgccagccg ggtggacccc
      241 agggcacagc cagcgacctc agggtgacac gcggagcccg ggagcgcaag gatggaggca
      301 cgattggtct ggggagtgct cgtcggccct ctgcgggttc tctgcgtcct gtgctgcctg
      361 ctgggccacg ccatcgctgc accgtcgccc atcatcaagt tccccggcga tgtctccccc
      421 aaaacagaca aagagttggc agtgcaatac ctgaacactt tctatggctg ccccaaggag
      481 agttgcaacc tctttgtgct gaaggacacc ctcaagaaga tgcagaagtt ctttgggctg
      541 ccccagacag gtgaccttga ccagaacacc atcgagacca tgcggaaacc aagatgtggc
      601 aacccagatg tggccaacta caacttcttt ccccgcaagc ccaagtggga caagaatcag
      661 atcacataca ggatcattgg ttacacacct gacctggacc ctgagacagt ggatgatgcc
      721 tttgctcggg ccttaaaagt atggagcgac gtaactccac tacgcttttc tcgaatccat
      781 gatggggaag ctgacatcat gatcaacttt ggtcgatggg agcatggaga tggataccca
      841 tttgacggca aggacggact cctggcacat gcctttgccc cgggcactgg tgttggggga
      901 gattctcact ttgatgacga tgagctgtgg actctaggag aaggacaagt ggtccgagta
      961 aagtatggga acgctgatgg cgagtactgc aagttcccct tcttgtttaa tggtcgggaa
     1021 tacagcagct gcacagacac tggccggagt gacggcttcc tctggtgttc caccacgtac
     1081 aactttgaga aggacggcaa atatggcttc tgtccccacg aagccttgtt taccatgggt
     1141 ggcaatggag atggacagcc ctgcaagttc ccgttccgct tccagggcac ctcttacaac
     1201 agctgtacca ccgagggccg tacagacggc taccgctggt gtggcaccac cgaggattat
     1261 gaccgggata agaagtatgg attctgccca gagactgcta tgtccactgt gggtggaaat
     1321 tcagaaggtg ccccatgtgt cttccccttc acttttctgg gcaacaagta tgagagctgc
     1381 accagcgctg gccgaagcga tggcaaggtg tggtgtgcaa ccacaaccaa ctacgatgat
     1441 gaccggaagt ggggcttctg tcccgaccaa ggatatagcc tattccttgt ggcagcccat
     1501 gagttcggcc atgccatggg gctggaacac tcacaggacc ctggagcttt gatggcccct
     1561 atctacacct acaccaagaa cttccgacta tccaatgatg acatcaaggg gatccaggag
     1621 ctctatgggc cctcccctga tgctgatact gacactggta ctggacccac gcctacactg
     1681 ggacctgtca ctcccgagat ctgcaagcaa gacattgtct ttgatggcat tgctcagatc
     1741 cgtggtgaga tcttcttctt caaggatcgg tttatttggc ggacagtgac accacgtgac
     1801 aagcccacag gtcccttgct ggtggccaca ttctggcctg agctcccgga aaagattgat
     1861 gccgtgtacg aggccccaca ggaagagaag gctgtgttct tcgcagggaa tgagtactgg
     1921 gtctattctg ccagcacttt ggaaagagga taccccaagc cactgaccag cctgggttta
     1981 ccccctgatg tccagcaagt agacgctgcc tttaactgga gtaagaacaa gaagacatac
     2041 atcttttctg gggacaagtt ctggagatac aatgaagtaa agaagaaaat ggaccccggt
     2101 ttcccgaagc tcatcgcaga ctcctggaat gccatccctg ataacctgga tgcagtcgtg
     2161 gacctgcagg gtggtggtca cagctatttc ttcaagggtg cttattacct gaagttggag
     2221 aaccaaagtc tgaagagtgt gaagtttgga agcatcaaat cggactggct gggctgctga
     2281 gctggccctg ttctgacggg ccgtacaatc ttcactgcac accgggccca ggaccctggg
     2341 gaaggacgtg aagaggcctg gttaccctgt ctcctgctct gtagttaatc agccttctcc
     2401 ttcacctggt gatttcagat ttaagagggt ggcttctttt ttgtgcccaa agaaaggtgc
     2461 tgaccgtatc cctcccaggt gctactttct cccgcccacc caaggggatg cttggatatt
     2521 cacaatgcag ccctcctttg ggctgccctg gtgctccaca cttcaggttc tccagcatga
     2581 atgatctttt gtgggttaca gcacactcag agtcaacaga gactgtctta ggagggcact
     2641 ggtggctcaa cagcctggca cagggcagtg ggatacaggt gtgccaaggt ggaaaccaga
     2701 gacatctggt gtctccctta cggctgccct ggcactttta ctactttagc tgtttgcttt
     2761 gtttgccctt tgctgtttgg ttcaaccttt tcagttttcc accacactgc atttttctca
     2821 ccgaaggact ccggttgtcg gacatcactg cacgatgcat ctggcctggc ctatggatgg
     2881 ctcccctcct cactttgtgt agaagcaact ccagtcactt cctccactgg ttggaggaga
     2941 accaagtcat cggcttcctg ctcagccttc ttgcttctcc ctttaacagt tccccatggg
     3001 aaatggcaaa aagtataaat aaaggcaccc tttgagtggc aaaaaaaaaa aaa
//
LOCUS       NM_001106835            1514 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus BCL2 interacting protein 2 (Bnip2), transcript
            variant 3, mRNA.
ACCESSION   NM_001106835 XM_001055775 XM_217191
VERSION     NM_001106835.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Cho,B., Choi,S.Y., Park,O.H., Sun,W. and Geum,D.
  TITLE     Differential expression of BNIP family members of BH3-only proteins
            during the development and after axotomy in the rat
  JOURNAL   Mol Cells 33 (6), 605-610 (2012)
   PUBMED   22639046
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Lu,M. and Krauss,R.S.
  TITLE     N-cadherin ligation, but not Sonic hedgehog binding, initiates
            Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4212-4217 (2010)
   PUBMED   20160094
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Oh,J.E., Bae,G.U., Yang,Y.J., Yi,M.J., Lee,H.J., Kim,B.G.,
            Krauss,R.S. and Kang,J.S.
  TITLE     Cdo promotes neuronal differentiation via activation of the p38
            mitogen-activated protein kinase pathway
  JOURNAL   FASEB J 23 (7), 2088-2099 (2009)
   PUBMED   19244314
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Sonn,S., Jeong,Y. and Rhee,K.
  TITLE     Nip2/centrobin may be a substrate of Nek2 that is required for
            proper spindle assembly during mitosis in early mouse embryos
  JOURNAL   Mol Reprod Dev 76 (6), 587-592 (2009)
   PUBMED   19117032
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474041.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217191.4, XM_001055775.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1514
                     /gene="Bnip2"
                     /note="BCL2 interacting protein 2"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
     exon            1..191
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..298
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1229
                     /gene="Bnip2"
                     /note="isoform 3 is encoded by transcript variant 3; Bcl-2
                     and E1B 19 kDa interacting protein; BCL2/adenovirus E1B
                     19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B
                     interacting protein 2; BCL2/adenovirus E1B 19 kDa
                     protein-interacting protein 2"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 2 isoform 3"
                     /protein_id="NP_001100305.1"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
                     /translation="MEGVELKEEWQDEDFPIPLPEDDSIEADILDVTDPDRQPGSLEV
                     NGNKVRKKLVAPDISLTLDPGEDSLWSDDLDEGGEVDLDGLDTPSENSDEFEWEDDLP
                     KPKTTEVIRKGSITEYAATEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYY
                     GDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIIYLNGATTRR
                     KMPSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVF
                     NLAELAELVPMEYVGIPECIKQCVSLLCFSSWIWARGLLLCLTVLKNTGL"
     misc_feature    393..737
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    393..737
                     /gene="Bnip2"
                     /note="Bcl2-/adenovirus E1B nineteen kDa-interacting
                     protein 2; Region: BNIP2; pfam12496"
                     /db_xref="CDD:463609"
     misc_feature    687..1133
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     misc_feature    687..1133
                     /gene="Bnip2"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p); Region:
                     SEC14; smart00516"
                     /db_xref="CDD:214706"
     exon            299..366
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..543
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..720
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..823
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..955
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1042
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1514
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactgaatc cgggtcagct gctgcctccg ggactgcagc tgagaccgtc cgggaaaagc
       61 tgggccccgt ctccacagcc gaccaagggc agcgggctct gcccggcgcc actttctgcg
      121 acctggccgt cagccccacg tcgccggcct ggaggggcaa agaggacgag ggggccgcgg
      181 cttcctccgg ggacctcggc tgcctggatt gccaggagct ggaagttgac attgagtcta
      241 ggctgaggat ggaaggtgtg gaactgaaag aagaatggca ggatgaagac ttcccaatac
      301 ctttaccaga agatgacagc attgaagcag atatactaga tgtaactgat ccagacagac
      361 agcctggctc gttagaagtt aatggaaaca aagtacggaa gaaactggtg gccccagaca
      421 tcagcctgac cttggatcct ggtgaagact ctctgtggtc agatgatttg gatgaaggtg
      481 gagaagttga cctggatggc ttagacaccc cctcagagaa cagtgatgag tttgagtggg
      541 aagatgatct tcccaaaccc aaaactactg aagtcattag gaaaggctca attactgaat
      601 atgcagctac agaagaaaag gaagatggac gccgctggcg catgttcagg attggagagc
      661 aggaccatag agtggacatg aaggcaatcg aaccctacaa aaaagttatt agccatggag
      721 gctattatgg ggatggctta aatgccattg ttgtatttgc tgtctgtttc atgcctgaga
      781 gtggtcagcc taactataga tatttgatgg acaatctctt taaatatgtt attggcactt
      841 tagagctgtt ggtagcagag aactacatga tcatttactt aaatggtgcg acaacgcgaa
      901 ggaaaatgcc cagtctggga tggctcagga gatgctacca gcaaatcgac agacgattaa
      961 ggaaaaacct aaagtctcta atcattgtgc acccctcttg gtttatccga acacttctgg
     1021 ctgttacaag accatttatc agttcaaaat tcagtcagaa gattagatac gtctttaatt
     1081 tggctgaact ggcggagctt gttcccatgg agtacgtcgg cataccagag tgcatcaaac
     1141 agtgcgtctc cctcctttgt ttctcttcct ggatctgggc aagagggctg cttctctgtc
     1201 tcactgtgct caagaacaca gggctgtaag gaagaggtag aggaggaacc tgtttgtccc
     1261 acagccttcc ctcacagctt ccccttgcag caccaggttt gcataaccgg aggggactgt
     1321 gctcatgagt ccttctgtac cttacgtgct gtttaagtct gagagatgac gtcctgagga
     1381 ggcagtcctg tagagtcgct tctctacttg acatgttact ctcacgagtt tatcgtgtta
     1441 ctgtgttact gaaggaactc ctattgctaa agaaacaagt tgttgtttaa agcagcctgg
     1501 tcttaatatt ttcc
//
LOCUS       NM_001436468            4495 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus atos homolog A (Atosa), transcript variant 1,
            mRNA.
ACCESSION   NM_001436468 XM_039081143
VERSION     NM_001436468.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081143.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.30012.1,
                                           SRR26643287.20620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JAXUCZ010000008.1  84575422-84575773
            353-469             JAXUCZ010000008.1  84576190-84576306
            470-654             JAXUCZ010000008.1  84629460-84629644
            655-857             JAXUCZ010000008.1  84630342-84630544
            858-983             JAXUCZ010000008.1  84630809-84630934
            984-2796            JAXUCZ010000008.1  84632504-84634316
            2797-2925           JAXUCZ010000008.1  84636524-84636652
            2926-3005           JAXUCZ010000008.1  84638961-84639040
            3006-3114           JAXUCZ010000008.1  84640128-84640236
            3115-3273           JAXUCZ010000008.1  84641283-84641441
            3274-3342           JAXUCZ010000008.1  84645727-84645795
            3343-3539           JAXUCZ010000008.1  84647790-84647986
            3540-4495           JAXUCZ010000008.1  84652148-84653103
FEATURES             Location/Qualifiers
     source          1..4495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4495
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="atos homolog A"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
     exon            1..352
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            353..469
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    379..381
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="upstream in-frame stop codon"
     CDS             454..3693
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 214, member A; atos
                     homolog protein A"
                     /codon_start=1
                     /product="atos homolog protein A isoform 1"
                     /protein_id="NP_001423397.1"
                     /db_xref="GeneID:300836"
                     /db_xref="RGD:1310552"
                     /translation="MKPDRDALDEYFEYDAEEFLVSLALLITEGRTPECSVKGRAESF
                     HCPPAQSRFPGAARHECSDKLAQCRQARRTRSEVTLLWKNNLPIMVEVMLLPDCCYSD
                     EGPSTEGTDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKALLLAVRSFVFFSQLS
                     AWLSVSHGAIPRNILYRISAADVDLQWSFSQTPTEHVFPVPNVSHNVALKVSVQSLPR
                     QAHYPVLTCSIHTNIGLYEKRIQEQELRACQHRGPGEVEYRCPSSSQSLCSKHTWTMA
                     PVSALHVRSGMPPEYTAAIRNVRLCPGTGSKSDNGTPQASVLGFSGTGEVRSQEASVR
                     TFKSLSVIDSSVSSCQSSRQPVGEPNPLIDSLIQDRQEVIARIAQHLIHCDPSSSRMS
                     ELPFNTPESTSLSPKLHPVSQESGYSRRCKEAFSVSFGSPEFGSPGDSKEGKVKEKLE
                     TRQGETCASHSPYPRQPAGEANPLIGSLLLERQDVIARIAQHLEHIDPTAHIPRPAFS
                     KHDSNSIPSKVFRSSFHDKTMLKKDRENVSVSATHTEVSLLGDRGDGKSPKPSKCFRS
                     FKNSPQEKSLKPEESAQHQNHPDDITHTARQELLNKAAGLLTSSNSSLCNESSLALIG
                     RLESTSCKLQLRKQEMSHETEKQCLHCNSIDKQICTNKCTEKIKDENSPGSLSHLQCD
                     ESRGIDPKIKVTMLEMPDYLNKYKTNCSNKDSKRSKTCEQNIQLGTENYLSEDTEGSK
                     STISDQLKTEQEENKDSVAGKPPSVKHCLSTSERLKNADMLDFSSQRTTLKHSSVWRK
                     HDFHSLDGTSTRAFHPQTGLPLLSSPVPQRKTQSGCFDLDTSLLHLRSLSSKSSRPCL
                     NIEADPGVHEKPFLSSSAPPITSLSLLGNFEESVLNYRLDPLGIVDGFTAEVGASGTF
                     CPTHLTLPVEVSFYSVSDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTV
                     VKMFVVVYDLRSMPANHQTFLRQRTFSVPVKQEMKRSINKENVQHTAQLLRYLIHLRF
                     QSSKSGKIYLHRDVRLLFSRKSMEVDSGAAYELKSYTESPTNPQFSPRC"
     misc_feature    3097..3270
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3097..3270
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Domain of unknown function (DUF4210); Region:
                     DUF4210; pfam13915"
                     /db_xref="CDD:404751"
     misc_feature    3514..3687
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     misc_feature    3514..3687
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /note="Chromosome segregation during meiosis; Region:
                     Chromosome_seg; pfam13889"
                     /db_xref="CDD:464021"
     exon            470..654
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            655..857
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            858..983
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            984..2796
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2925
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3005
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3114
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3273
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3342
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3539
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..4495
                     /gene="Atosa"
                     /gene_synonym="Fam214a; RGD1310552"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaag cgagcgagcc tggcaggcag cggggccggt ggatgcgcgg ggcgcggcgt
       61 ctcggcgtct cggcagccgc ggggtcgctg tgcgctgcgc tcggggaggc gtggcccgga
      121 gcacagagtg tgatgtgagc ggcccggcgg ccgcagagag cagtgccggg aggaggagcg
      181 aggggtcccg gagggcggcg agcgggcggg ctatgggagc cgttcccggg tgggcagaga
      241 cacgcgtggg tcggcgcggc tgaggacatg cccagactct gctgctgacc ggctccggct
      301 ggaacccggc tactgaagcc tcggcgaggt tagccagagg ggatcctcgc agcgtttgga
      361 aaacgaagca gaagccattg agtcagccgt gtgccggttg gaagaaccca cacctgtgtt
      421 ttacagcact ttgggtggaa attggatgcc aaaatgaagc cagaccgaga tgccttggat
      481 gagtattttg aatatgatgc agaggagttc ttggtctctt tggccttgct gataactgaa
      541 ggccgaaccc ctgagtgttc cgtgaaaggc cgtgcagaga gtttccactg ccctccagcg
      601 cagtctcgtt tcccaggcgc agccagacat gagtgcagcg acaagctggc ccagtgtcgc
      661 caagccagac gaaccagatc tgaggtcacg ctgttgtgga aaaataatct tccaatcatg
      721 gtagaagtga tgcttctgcc agattgctgc tacagtgacg agggccctag cacagagggg
      781 acagatctga atgaccctgc cattaaacaa gatgcactgt tactggagag gtggatcttg
      841 gagccagttc cccgacagaa tggcgatcgc ttcatcgaag agaaggcact tctgctggct
      901 gtcagatcat tcgtgttttt ttctcagtta agtgcttggc tgagtgtttc tcatggtgct
      961 attccacgaa acattcttta cagaatcagt gctgctgatg tcgacctgca gtggagtttt
     1021 tcacagactc caactgagca tgtgtttccc gttcccaatg tctctcacaa cgtggccttg
     1081 aaagtcagcg ttcagtcctt acccagacaa gctcattatc cagttttgac ctgtagtatc
     1141 catactaata ttggtctgta tgagaagaga attcaggaac aggagcttcg agcctgtcag
     1201 caccgtggcc ctggtgaagt ggagtaccgt tgtcccagca gctctcagag tctgtgcagc
     1261 aagcacacat ggaccatggc acctgtgagt gccctgcatg tcagaagtgg catgcctcct
     1321 gagtacactg cagccattag aaatgtcagg ctctgcccag gcacaggtag caagtctgac
     1381 aatggaacac ctcaagccag cgtcctgggc ttcagtggca ctggagaagt gaggtcccag
     1441 gaggcatcag tgagaacttt caaatcactc tctgtgatcg attccagtgt ctccagctgt
     1501 cagagctccc ggcagccagt aggggagcct aaccctttaa tcgactccct gattcaggat
     1561 cgacaagaag tcattgccag gattgctcag cacttgattc actgtgaccc cagctcctct
     1621 cgcatgtctg aactcccctt taacacccca gagtccactt cacttagccc aaagcttcac
     1681 ccagtttcac aggagagtgg gtattcgaga agatgcaaag aagcattctc tgtctctttt
     1741 gggagtccag agtttggctc cccaggagac agcaaggagg ggaaagtgaa agagaagctg
     1801 gaaaccaggc aaggagaaac ctgtgcctct cacagtccct accctcggca gcctgctggg
     1861 gaggcaaacc cactgattgg ctctttgctt ctggagcggc aggatgtcat agccaggatc
     1921 gcacagcact tggagcacat cgaccccaca gctcacattc cccggcctgc gttcagcaag
     1981 cacgactcca attccattcc ttctaaagtg ttcaggagtt catttcatga caaaaccatg
     2041 ttgaagaagg acagagagaa tgtctctgtt tctgctactc atacagaagt gtccttattg
     2101 ggagacagag gtgatgggaa aagccccaaa cctagtaaat gtttccgatc tttcaaaaac
     2161 agtcctcaag aaaagtctct gaaacctgaa gaaagcgctc agcatcagaa ccatcctgat
     2221 gacatcaccc acacagccag gcaggagttg ctgaacaagg ctgctggctt actcacttcc
     2281 tctaactcgt ccctctgcaa tgaaagcagc ttggctttga ttggcagatt ggaaagtaca
     2341 tcttgtaaat tacaacttag gaagcaagaa atgagccatg aaactgagaa acagtgtttg
     2401 cattgcaaca gtattgacaa acagatttgc acaaataaat gcacagagaa aataaaagat
     2461 gagaatagcc cgggctctct cagtcatctc cagtgtgatg agtcaagagg tattgaccca
     2521 aaaataaaag tgactatgtt ggaaatgcct gactatttga acaagtacaa aactaattgt
     2581 tcaaataaag actccaaaag atcaaagaca tgtgagcaaa acattcagct tggcacagaa
     2641 aattatctca gtgaagatac tgagggttcc aaaagcacaa tatcagacca actaaaaact
     2701 gagcaggagg aaaacaaaga ttcagttgcc ggaaaacctc caagtgtaaa gcactgtctg
     2761 tctacaagcg aaagactgaa aaatgcagac atgttggact tttcctcaca gaggactaca
     2821 ctgaagcatt caagtgtctg gaggaaacac gattttcatt ccctggatgg gacatcaacc
     2881 agagcctttc atcctcagac agggctgcct ctcctctcaa gcccagttcc tcaaagaaaa
     2941 acacagtcag gttgctttga tctagacacg tcactactgc atctgagaag tctatcctcc
     3001 aaaagctctc gaccgtgtct gaacattgaa gcggacccag gtgttcatga aaagcctttt
     3061 ttgagttcaa gtgctccacc aatcacaagt cttagtctcc tagggaattt tgaggaatcg
     3121 gttctgaatt accgtttaga ccccctcggc atagttgatg gcttcactgc tgaggtggga
     3181 gccagtggga ctttctgccc tacgcacttg actctgccgg tggaagtgtc gttctacagt
     3241 gtttcggatg ataacgctcc ctcgccttat atgggtgtga ttactttaga gtcccttggt
     3301 aaaaggggtt atcgagtacc tccttcagga acgatacaag tgaccttatt caatcccaat
     3361 aagactgtgg tgaagatgtt tgttgtcgtg tatgacctac gaagtatgcc agccaatcac
     3421 cagacattcc tgcggcagag gacgttttct gttcctgtta aacaagaaat gaagagaagt
     3481 attaacaaag agaatgtcca gcacacggca cagttactac gctacctcat acacctgagg
     3541 ttccagagct ctaaatctgg gaagatctac ctccatagag atgtccggct cctgttctct
     3601 agaaagtcca tggaggttga tagcggtgct gcttatgaac tcaagtctta caccgaatcg
     3661 ccaacaaacc cacagttttc accaagatgc tgataaggga gacggattaa aagtatttgc
     3721 tcagtaccca agcttgaacg tgagcattca ccgagtggaa tacatccaat gagagccagt
     3781 ggagtggagt ggccctcctc ttgtcctgga ccagatttta ttaaaggacc cctgaactga
     3841 gacccatgac tcctaagtgg actggaagca cccctgtctt cacccttttc gtactgttga
     3901 aaccacttca ttggacagtt gcaatagcaa aatccccagt tagattagtg tttacacatt
     3961 ttatttctgt tatttaatat ttaatgtttt ccttaatagt caagtgatgt ttgtctctag
     4021 tgttctaatg tagcacaatc tatgtaaaat catactatgt atttttgaca ttaatgttga
     4081 aattgaaata tatgcataag tctttaattt tgtgtggtgt gttttaagtg ctattcattt
     4141 aagctactga aaatgagaat gaaatgttgg gcttctttaa gattaatgca ctatgcaagc
     4201 atgtatgctt ttgatatctc tccaggttag gttttaaaga actcaccagg gctgttccca
     4261 ggggtccgac aaagctgctc ccatcctcct ggcaaacact cagcctcctg cccattctca
     4321 tccttctaag atccccccca ccccaaaaac attctatttt ccctgaatca ctactgtaga
     4381 ggttttactt taaattgcta tcccatgcta cataattttc tcacactgtt aaaaagaata
     4441 tgtactttga aaagaattta atatttatat tgtaaatata tgcaaaaaac taaaa
//
LOCUS       NM_001436482            3273 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus glutamine-rich 1 (Qrich1), transcript variant 1,
            mRNA.
ACCESSION   NM_001436482 XM_006243747
VERSION     NM_001436482.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243747.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1540116.1,
                                           SRR26360181.1765523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000008.1  118095438-118095575
            139-468             JAXUCZ010000008.1  118106884-118107213
            469-1500            JAXUCZ010000008.1  118112261-118113292
            1501-1678           JAXUCZ010000008.1  118120474-118120651
            1679-1833           JAXUCZ010000008.1  118121209-118121363
            1834-1948           JAXUCZ010000008.1  118122735-118122849
            1949-2057           JAXUCZ010000008.1  118131517-118131625
            2058-2209           JAXUCZ010000008.1  118131953-118132104
            2210-2300           JAXUCZ010000008.1  118132470-118132560
            2301-3273           JAXUCZ010000008.1  118134029-118135001
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3273
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
     exon            1..138
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            139..468
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    145..147
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="upstream in-frame stop codon"
     CDS             160..2493
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_001423411.1"
                     /db_xref="GeneID:301004"
                     /db_xref="RGD:1311095"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQSATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPQPQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     misc_feature    <175..303
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    <175..303
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Caspase activation and recruitment domain: a
                     protein-protein interaction domain; Region: CARD; cd01671"
                     /db_xref="CDD:260018"
     misc_feature    1957..2439
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     misc_feature    1957..2439
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /note="Domain of unknown function (DUF3504); Region:
                     DUF3504; pfam12012"
                     /db_xref="CDD:463430"
     exon            469..1500
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1678
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1833
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1948
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2057
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2209
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2300
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..3273
                     /gene="Qrich1"
                     /gene_synonym="RGD1311095"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatgtaaga tggcgcccag ggagctgtga ggagaaaatc ctgtcggtct tggagcagcg
       61 gtggcagaac cgaggcccca ggcggtgaag cggggccgga gggtagagtg gaggcagcgg
      121 cggcggtgac gtcgccggga accctaagga ctctgcaata tgaataattc tctagagaac
      181 accatctcat ttgaagagta catccgagta aaggcgaggt ctgtcccgca acacaggatg
      241 aaggaatttc tggactcgct ggcttctaag ggaccagaag ctcttcagga gttccagcag
      301 tctgccacca ccaccatggt gtaccagcag ggtgggaact gcatttatac agacagcact
      361 gaagtggctg ggtctttgct tgaacttgct tgtccagtca caaccagtgt tcaaccacaa
      421 actcagcaag agcagcagat ccaggttcag cagccacagc aggttcaggt acaggtgcag
      481 gtacagcagt ctccacagca ggtctcagct cagcagcttt ccccgcagtt caccgttcac
      541 cagcctgctg agcaacccat ccaggtccag gtgcagatcc agggccaagc accacagtcc
      601 gcagccccct ccatccagac tccatcactg cagagcccca gcccctcgca gctgcaagca
      661 gcccagatcc aggtgcagca cgtgcaggca gcgcagcaga tccaggctgc agaaatccca
      721 gaggagcata tcccacatca acagatccaa gctcagttgg tggcaggcca atctcttgct
      781 gggggccagc agattcaaat tcagaccgtg ggcgctcttt ccccaccacc ctcccagcag
      841 ggctcaccca gggaagggga gcggagggtt ggcacagcca gtgtccttca accagtgaag
      901 aaacgcaaag tggacatgcc catcaccgtg tcctatgcca tctcagggca gccagtggcc
      961 accgtgctgg ccattccaca aggccagcaa cagagttacg tgtctttgag gccagactta
     1021 ctgacagtag acagtgccca cctgtacagc gccactggga ccataactag ccctacagga
     1081 gaaacttgga ccatccctgt ttattccgcc cagccccggg gggaccctca gcagcagagc
     1141 attacccaca ttgccattcc ccaggaagcc tacaatgcag ttcacgtcag tggctcaccc
     1201 acggctctgg cagctgtaaa gctggaggat gacaaggaga agatggtggg caccacatcc
     1261 gtagtgaaga actcccatga agaggtagtg cagacccttg caaactctct ctttccagca
     1321 cagttcatga atggcaacat ccacattcca gtggctgtgc aggctgtagc aggcacgtac
     1381 cagaatacgg ctcagactgt acatatatgg gacccacagc agcagccgca acagcaaact
     1441 gcacaagaac agacaccacc acagccacag caacagcagc agctgcaggt cacttgttca
     1501 gcacaaactg ttcaggtcgc tgaagttgag ccacagtcac aaccgcagcc ttcaccagag
     1561 cttttgcttc caaattcact gaagccagaa gaagggctag aagtatggaa aaactgggct
     1621 cagaccaaga atgctgaact agaaaaggat gctcaaaaca gattggcccc cattgggagg
     1681 cgccagttgc tacgattcca agaagatctg atctcatctg ctgtggctga attgaattat
     1741 ggcctttgtt taatgacacg agaagctcgg aatggagaag gtgaacccta tgacccagat
     1801 gtactctact acattttctt gtgtatacag aagtatcttt ttgaaaatgg aagagtagat
     1861 gacatattct ctgatcttta ctatgttcgt tttaccgaat ggctacatga agttctgaag
     1921 gacgtgcagc cccgggtcac tccacttggc tatgttctgc ccagccacgt gactgaagag
     1981 atgctgtggg aatgcaagca gcttggggca cattcccctt cgacactgct gaccaccctc
     2041 atgttcttca acaccaagta ctttctgttg aagacagtag atcagcacat gaagctggcg
     2101 ttctccaagg tcctccggca gacaaagaag agcccctcga atcctaagga taaaagcact
     2161 agtatccgct acctgaaggc cctcggaata catcagactg gccagaaagt tacagatgac
     2221 atgtatgcag aacagacaga aaatccagag aacccattaa ggtgtcccat caagctctac
     2281 gatttctacc tcttcaaatg cccccagagt gtgaaaggcc gaaatgacac cttttacctg
     2341 actcctgagc ctgttgtggc tcccaacagc ccgatctggt actcagtcca gcctatcagc
     2401 cgagagcaga tgggacagat gctgacccgg atcctggtta tacgagagat tcaagaagcc
     2461 attgccgtgg ccaacgcaac caccatgcac tgaggtgcct cagccacagg aaaaaaaaaa
     2521 atccaggaaa aaccagacag acttttacac taaaggagag gcctccattt ttttcttttt
     2581 ctttttcctt caattcgtag ttctaatgct tttcaggcga cttctgttaa aaatgtaaaa
     2641 gacaatgttg ccctctttgc atcttcataa aatgggcaga ccccctggtt catgggtata
     2701 tggttttcct agaacttgat gtcctaggaa gtggttggct tttacctttc ttttcctttt
     2761 ttttcttttg tctgggctgg agtgtggggg aagggacttg gactgtatgg agaaatatag
     2821 gcccttccct tcctcaaggc agatggagca gccgatgaat caaccctcct gcaaaccccc
     2881 acctttcact ctggaccggc aggcttaacc actcggagcc acgatttttc tttttttttt
     2941 tttttttttt ttttttaaat gctcagacat aaacttagca tcttgatgga ataaaaatga
     3001 ggggaacttc aattatgatt tttattaaag acaatttcta ttacaccctt ctttatgaca
     3061 agtgacatag atgttaaagt aaaaacttta ccatgctttt tttttttttt tttttttttt
     3121 ttggcctaac attgaggcct taaacctgag gctcctgtgc ctgatggaat tcttgtaaca
     3181 tacacttgtg tatcatataa agataccact ctttctctta tgtattctta ttctagttgt
     3241 ttattaagaa tgacaagcac gtcttttcaa caa
//
LOCUS       NM_001436511            2475 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase family, member 16
            (Parp16), transcript variant 2, mRNA.
ACCESSION   NM_001436511 XM_039081504
VERSION     NM_001436511.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Yang,D., Wang,Q., Wei,G., Wu,J., Zhu,Y.C., Zhu,Q., Ni,T., Liu,X.
            and Zhu,Y.Z.
  TITLE     Smyd3-PARP16 axis accelerates unfolded protein response and
            vascular aging
  JOURNAL   Aging (Albany NY) 12 (21), 21423-21445 (2020)
   PUBMED   33144524
  REMARK    GeneRIF: Smyd3-PARP16 axis accelerates unfolded protein response
            and vascular aging.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Jwa,M. and Chang,P.
  TITLE     PARP16 is a tail-anchored endoplasmic reticulum protein required
            for the PERK- and IRE1alpha-mediated unfolded protein response
  JOURNAL   Nat Cell Biol 14 (11), 1223-1230 (2012)
   PUBMED   23103912
  REMARK    Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Di Paola,S., Micaroni,M., Di Tullio,G., Buccione,R. and Di
            Girolamo,M.
  TITLE     PARP16/ARTD15 is a novel endoplasmic-reticulum-associated
            mono-ADP-ribosyltransferase that interacts with, and modifies
            karyopherin-ss1
  JOURNAL   PLoS One 7 (6), e37352 (2012)
   PUBMED   22701565
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081504.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.3239421.1,
                                           SRR26643289.23250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000008.1  74626392-74626563
            173-455             JAXUCZ010000008.1  74627029-74627311
            456-593             JAXUCZ010000008.1  74633886-74634023
            594-800             JAXUCZ010000008.1  74636720-74636926
            801-972             JAXUCZ010000008.1  74640043-74640214
            973-1114            JAXUCZ010000008.1  74642093-74642234
            1115-2475           JAXUCZ010000008.1  74643248-74644608
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2475
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="poly (ADP-ribose) polymerase family, member 16"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
     exon            1..172
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    162..164
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="upstream in-frame stop codon"
     exon            173..455
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1250
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 16; PARP-16;
                     ADP-ribosyltransferase diphtheria toxin-like 15; mono
                     [ADP-ribose] polymerase PARP16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP16"
                     /protein_id="NP_001423440.1"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
                     /translation="MQLSNRAAARESVSRDVLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQTWDLVSWILSSKILTIHSAEK
                     AEFEKIQQLTGAPHTPVPIPDFLFEIEYFDPANARFYETKGGRDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGRGWQHSLLGQTLSCVAVCEVI
                     DHPDVKCQTKKKDSKEIDRSRARIKHSEGGDVPPKYFVVTNNQLLRVKYLLVYSQKQP
                     KRASSQLSWLCSHWFMVAMSLYLLLLLIVSVTNSSAFQHFWNRLKR"
     misc_feature    324..551
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="ARTD15 N-terminal domain; Region: ARTD15_N;
                     pfam18084"
                     /db_xref="CDD:465641"
     misc_feature    324..551
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="ARTD15 N-terminal domain; Region: ARTD15_N;
                     pfam18084"
                     /db_xref="CDD:465641"
     misc_feature    585..1100
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     Region: PARP; pfam00644"
                     /db_xref="CDD:395519"
     misc_feature    585..1100
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     Region: PARP; pfam00644"
                     /db_xref="CDD:395519"
     misc_feature    858..860
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="Nicotinamide-stacking aromate.
                     /evidence=ECO:0000250|UniProtKB:Q8N5Y8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Q4.1); other site"
     misc_feature    1134..1196
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Q4.1);
                     transmembrane region"
     exon            456..593
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            594..800
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            801..972
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1114
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..2475
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattccgga ggctgtaagg tagagagaaa ggactttggg tcagctacaa tgtcttgagg
       61 aagtattgtg tcactccgac cctcagtttt ccctgggtgt caagtggctc cttttgtgca
      121 acgtgtcagc tccagaggaa accgacttat tcaacaggtg gtaattccca agctccaccc
      181 ccgggctggg aaacctggca gcagacggtc caaggtcccc cgggcccagg ccccgcactg
      241 cccctccttg cctcctcccg accacgcgct acgagcccgg gatgcagctc tccaacaggg
      301 cggcagccag ggagtcggtg agccgcgacg tgctggccgc ggacctccgc tgcagcctct
      361 tcgcctcagc gctgcagagc tacaagcggg actcggtgct gcggcccttc cccgcctcct
      421 acgcccgcca cgactgtaag gacttcgagg ccctgcttgc ggacactggc aggttaccta
      481 acttgaagga acttctgcag tcctccaggg acacagacaa acagacctgg gacctggtga
      541 gctggattct atcctccaag atcctgacaa tccacagtgc agagaaggcc gagtttgaaa
      601 agatccagca gctgaccggt gcacctcaca cacctgtccc catcccagat ttcctttttg
      661 aaattgagta ctttgacccg gccaatgcca gattctatga gaccaaagga gggcgagacc
      721 tgatctatgc cttccatggc agccgcctag agaacttcca ttccatcatt cacaacggcc
      781 tgcattgtca cctgaacaag acttctctgt ttggagaggg gacctacctc acaagtgact
      841 tgagcctggc cctcatttat agtcctcacg gccgtgggtg gcagcatagc ctccttggcc
      901 agacccttag ctgtgtagct gtgtgtgagg tcatcgacca tccagatgtc aagtgccaaa
      961 ccaagaagaa ggattccaag gaaatcgacc gcagcagagc tcgaatcaag cacagcgaag
     1021 ggggagatgt cccccctaag tactttgtag tcactaacaa ccagcttctg cgggtgaagt
     1081 acctactggt gtattcccag aagcagccca agagggcctc gagccagctt tcctggctgt
     1141 gcagccattg gttcatggtc gcgatgtccc tctatctgct gctgctgctc atcgtcagtg
     1201 tcaccaactc ctctgccttc cagcacttct ggaatcgcct gaagagatga tccctggtgc
     1261 ttggagtggg gccactcacc gtgtgcctta tgggcgctcg tcctctacct cctgcatgtc
     1321 acatccagtc aggtcgagtc tgggaaccag ttgcggggtg cacagggcga tgtttatatg
     1381 ccataagtgt actgattacc ttgttggtgt gctcagacac agtccagtca gcggggaccc
     1441 tggcccctca cttgctggct tcaggggtat cctaccatct gcttcttccg aaacagtcta
     1501 gggaggtggc tctccagcca gggccaaagg aagaagtcct gctgcattta aaagcaaagt
     1561 gtccaagctg tccgcggtgt gtttgtaata gcccagatgg aggcctcctg acgttaatgc
     1621 ctctggaaga cagaacatgt gcaacgggaa cgataaatca ccaggcggct gccttgtttt
     1681 gactcaagac acccaagagg gacagtcgtg tttctcataa aaatatcagt gggaccgttt
     1741 gggaattcca tcggctttag tctgcgggtg caaaacattt taacagtttt ctcagatcaa
     1801 caacagtctc tgccacagct gtactcccct gcctcctcaa ccacacagga ggaggagcca
     1861 caggcgggat aacaaaatgc agatttgaca actagcaact ctgtcatctt tttctaaaaa
     1921 tgaccaactg ctgattacag ctcaaatgga accaaatgtt tgtgtttctg tttctttgtt
     1981 gtttgtttga ccaattagcc tctatgagcc aaatagagag ggagctgtgt gagccttgag
     2041 caccgagtgg ctggatccac agcctctgtc tggttttgct atggagaagg gtccaagcca
     2101 taggctcgct agggtcctca ttcccacgaa gctgccttga taaacaacac tctaggcttt
     2161 caggggccct gatggccttc aaggcagagg cctgcctcag tgggccacag atctccacag
     2221 gccgagcctc tgtccaagga gcctgagctt gagttgaaag cagagccccc cggccgttcg
     2281 tgctgtgttg tttattctct ccttcctgcc agtcttcaat ggcgaagaac tctgtctact
     2341 ggcaatggga tttccataga gaaggaggaa atcatttttc cccctatgat ttgtaaagct
     2401 tgtgaagaag ccactatcat gatttttaaa ccaagtagtg agatgtttaa aaaccaataa
     2461 agatattttc ctaaa
//
LOCUS       NM_001436464            2293 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus TATA-box binding protein associated factor 6
            (Taf6), transcript variant 1, mRNA.
ACCESSION   NM_001436464 XM_063271144
VERSION     NM_001436464.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. doi:
            10.1038/nature17984. PMID: 27096372]
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Malkowska,M., Kokoszynska,K., Rychlewski,L. and Wyrwicz,L.
  TITLE     Structural bioinformatics of the general transcription factor TFIID
  JOURNAL   Biochimie 95 (4), 680-691 (2013)
   PUBMED   23146842
  REMARK    Review article
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Kamileri,I., Karakasilioti,I., Sideri,A., Kosteas,T., Tatarakis,A.,
            Talianidis,I. and Garinis,G.A.
  TITLE     Defective transcription initiation causes postnatal growth failure
            in a mouse model of nucleotide excision repair (NER) progeria
  JOURNAL   Proc Natl Acad Sci U S A 109 (8), 2995-3000 (2012)
   PUBMED   22323595
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Wilhelm,E., Kornete,M., Targat,B., Vigneault-Edwards,J.,
            Frontini,M., Tora,L., Benecke,A. and Bell,B.
  TITLE     TAF6delta orchestrates an apoptotic transcriptome profile and
            interacts functionally with p53
  JOURNAL   BMC Mol Biol 11, 10 (2010)
   PUBMED   20096117
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Tatarakis,A., Margaritis,T., Martinez-Jimenez,C.P., Kouskouti,A.,
            Mohan,W.S. 2nd, Haroniti,A., Kafetzopoulos,D., Tora,L. and
            Talianidis,I.
  TITLE     Dominant and redundant functions of TFIID involved in the
            regulation of hepatic genes
  JOURNAL   Mol Cell 31 (4), 531-543 (2008)
   PUBMED   18722179
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Pointud,J.C., Mengus,G., Brancorsini,S., Monaco,L., Parvinen,M.,
            Sassone-Corsi,P. and Davidson,I.
  TITLE     The intracellular localisation of TAF7L, a paralogue of
            transcription factor TFIID subunit TAF7, is developmentally
            regulated during male germ-cell differentiation
  JOURNAL   J Cell Sci 116 (Pt 9), 1847-1858 (2003)
   PUBMED   12665565
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Bell,B., Scheer,E. and Tora,L.
  TITLE     Identification of hTAF(II)80 delta links apoptotic signaling
            pathways to transcription factor TFIID function
  JOURNAL   Mol Cell 8 (3), 591-600 (2001)
   PUBMED   11583621
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Wieczorek,E., Brand,M., Jacq,X. and Tora,L.
  TITLE     Function of TAF(II)-containing complex without TBP in transcription
            by RNA polymerase II
  JOURNAL   Nature 393 (6681), 187-191 (1998)
   PUBMED   9603525
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Kida,S., Umehara,T. and Horikoshi,M.
  TITLE     Three distinct regions in a rat TFIID subunit containing histone H4
            homology
  JOURNAL   Gene 161 (2), 303-304 (1995)
   PUBMED   7665101
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Weinzierl,R.O., Ruppert,S., Dynlacht,B.D., Tanese,N. and Tjian,R.
  TITLE     Cloning and expression of Drosophila TAFII60 and human TAFII70
            reveal conserved interactions with other subunits of TFIID
  JOURNAL   EMBO J 12 (13), 5303-5309 (1993)
   PUBMED   8262073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063271144.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1672889.1,
                                           SRR26360176.2093579.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000012.1  22177903-22177949   c
            48-263              JAXUCZ010000012.1  22175128-22175343   c
            264-350             JAXUCZ010000012.1  22174655-22174741   c
            351-504             JAXUCZ010000012.1  22174403-22174556   c
            505-561             JAXUCZ010000012.1  22174177-22174233   c
            562-681             JAXUCZ010000012.1  22173936-22174055   c
            682-827             JAXUCZ010000012.1  22173518-22173663   c
            828-905             JAXUCZ010000012.1  22173329-22173406   c
            906-1007            JAXUCZ010000012.1  22173115-22173216   c
            1008-1190           JAXUCZ010000012.1  22172823-22173005   c
            1191-1265           JAXUCZ010000012.1  22172035-22172109   c
            1266-1391           JAXUCZ010000012.1  22171810-22171935   c
            1392-1565           JAXUCZ010000012.1  22170679-22170852   c
            1566-1763           JAXUCZ010000012.1  22170358-22170555   c
            1764-2293           JAXUCZ010000012.1  22169570-22170099   c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2293
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="TATA-box binding protein associated factor 6"
                     /db_xref="GeneID:288533"
                     /db_xref="RGD:1311608"
     exon            1..47
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            48..263
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="upstream in-frame stop codon"
     CDS             108..2144
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="isoform 1 is encoded by transcript variant 1; TAF6
                     RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor, 80 kDa; transcription initiation
                     factor TFIID subunit 6; TFIID subunit p80; TAFII80;
                     TAFII-70; TAFII-80; TAF(II)70; transcription initiation
                     factor TFIID 70 kDa subunit; transcription initiation
                     factor TFIID 80 kDa subunit"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 6
                     isoform 1"
                     /protein_id="NP_001423393.1"
                     /db_xref="GeneID:288533"
                     /db_xref="RGD:1311608"
                     /translation="MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVS
                     YRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGR
                     ELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAE
                     ATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSV
                     EQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNL
                     ALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAA
                     RLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLI
                     LPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRG
                     EFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLK
                     VPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGST
                     TTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGPGSVQKYIVVSLPPTGEGKGGPPSH
                     PSPVPPSSSSPSPLGGSALCGGKQETGDSPPPAPGTPKANGSQPTGPSSPQPAL"
     misc_feature    132..1331
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Transcription initiation factor TFIID, subunit TAF6
                     (also component of histone acetyltransferase SAGA)
                     [Transcription]; Region: TAF6; COG5095"
                     /db_xref="CDD:227426"
     misc_feature    132..1331
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Transcription initiation factor TFIID, subunit TAF6
                     (also component of histone acetyltransferase SAGA)
                     [Transcription]; Region: TAF6; COG5095"
                     /db_xref="CDD:227426"
     misc_feature    465..467
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    531..710
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63801.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    747..1397
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="C-terminal domain of TATA Binding Protein (TBP)
                     Associated Factor 6 (TAF6); Region: TAF6C; cd08050"
                     /db_xref="CDD:381749"
     misc_feature    747..1397
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="C-terminal domain of TATA Binding Protein (TBP)
                     Associated Factor 6 (TAF6); Region: TAF6C; cd08050"
                     /db_xref="CDD:381749"
     misc_feature    order(759..767,771..776,783..785,816..821,828..830,
                     840..842,849..854,870..872)
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381749"
     misc_feature    order(759..767,771..776,783..785,816..821,828..830,
                     840..842,849..854,870..872)
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381749"
     misc_feature    759..854
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    759..854
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    849..851
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    864..866
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    873..980
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    873..980
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    897..899
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    1008..1139
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1008..1139
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1158..1256
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1158..1256
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1260..1394
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1260..1394
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:381749"
     misc_feature    1677..1829
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63801.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1677..1679
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); methylation site"
     misc_feature    1938..2141
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63801.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1983..1985
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62311; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    2007..2009
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    2013..2015
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49848; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    2064..2066
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     misc_feature    2085..2087
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63801.1); phosphorylation site"
     exon            264..350
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            351..504
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            505..561
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            562..681
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            682..827
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1007
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1190
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1265
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1391
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1565
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1763
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2293
                     /gene="Taf6"
                     /gene_synonym="TAF(II)80; TAFII70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccaaga tggcgccgag cgccgggtga gcggcgcctt ggcagcggat ctccatctct
       61 ccaccctggg gtgacatcct tccagggaca ggagctggaa ctccagcatg gctgaggaga
      121 agaaactgaa actcagcaat accgtgttgc cctccgagtc tatgaaggtg gtggcagaat
      181 ccatgggcat tgctcagatt caggaggaga cttgccagct actgacagat gaggtcagct
      241 accgcatcaa ggagattgcc caggatgctt tgaagttcat gcacatgggg aaacgacaga
      301 agctcactac cagtgacatt gactatgcat tgaaattaaa gaatgtggag ccactatatg
      361 gcttccatgc tcaggagttc atccctttcc ggtttgcctc tggtgggggc cgggagctgt
      421 acttctatga agagaaggaa gtggacctga gtgatatcat caacacccct ctgcctcggg
      481 tgcctctgga tgtctgcctc aaagctcatt ggctgagcat tgaaggctgc cagccagcta
      541 taccagagaa tccaccccca gctcccaaag agcagcagaa ggccgaggcc acagaacccc
      601 tgaagtcagc aaagccaggc caagaagaag atggaccctt gaaaggcaaa ggtcaagggg
      661 cagctgcagc tgatggcaaa ggaaaagaga agaaggcacc tcccttgctg gaaggggccc
      721 ctttccgcct gaagccccgc agcatccatg agctgtccgt ggagcagcag ctgtactaca
      781 aggagatcac agaagcctgt gtgggatcct gtgaggccaa gagagcggaa gctctgcaga
      841 gcattgccac agatcctgga ctctatcaga tgttaccacg gtttagtacc ttcatctcag
      901 agggggtccg tgtgaatgtg gttcagaata acctggcctt gctcatctac ttgatgcgaa
      961 tggttaaggc cctgatggac aaccccacac tgtatcttga gaaatatgtg cacgagctga
     1021 ttcctgcagt aatgacctgc attgtgagca gacagctgtg cctgcggcca gatgtggaca
     1081 atcactgggc actccgggat tttgctgccc gtctagtggc ccagatctgt aagcatttca
     1141 gcacaaccac caacaacatc caatcccgaa tcaccaagac ctttaccaag agctgggtgg
     1201 atgagaagac tccatggaca actcgatatg gctccattgc aggcctggca gagctggggc
     1261 atgatgtgat taagacccta attctgccaa ggctgcagca ggaaggggag cggatccgaa
     1321 gtgtcttgga cggacctgtt ctgagcaaca tcgaccgtat cggagcagac catgttcaga
     1381 gccttctcct gaaacactgt gccccagtat tggcgaagct gcgccctcca cctgacaatc
     1441 aggatgccta ccggggagaa tttgggtccc ttgggcccct tctctgctcc catgtggtga
     1501 aggccagggc ccaggccgct cttcaagctc agcaggtcaa caggaccaca ctcaccatca
     1561 cacagcctcg gcccacactg accctctcac aggcccctca gccaggccct cgtacccctg
     1621 gcttattgaa ggtccctggc tctattgcct tgcctgtcca gacactggtg tctgcaagag
     1681 ctgctgcccc tcctcagcct tctcctcctc caacgaagtt tattgtaatg tcctcatctt
     1741 ccagtgcctc atcaacccag caggtcctgt ccctcagcac ctcagctcct ggttcaggct
     1801 ctaccactac ctctcctgtc accaccacag ttcccagcgt gcagcccatt gtcaagctgg
     1861 tctccactgc taccactgca cccccaagca cagcccctgc tggtcctggc agtgttcaga
     1921 aatacattgt ggtctctctt cccccaacag gggaaggcaa aggaggccct ccttctcatc
     1981 cttctccagt cccaccttca tcttcttcac catctccact tgggggcagt gccctctgtg
     2041 gggggaagca ggaaactggg gacagccccc ctccagctcc agggactcca aaggctaatg
     2101 gctcccagcc tactggacct agctctcccc agcctgctct gtgatattgt cacatgtgct
     2161 gacctcctct cttctgcaga ttcctacaca cacaaacaac gtgtgaggga ggaagaagaa
     2221 agatgttttc cccagtgact ttctttttag attctgtaca gtaagttcct cagaataaaa
     2281 gttggatttg taa
//
LOCUS       NM_001436476            1878 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus mortality factor 4 like 1 (Morf4l1), transcript
            variant 1, mRNA.
ACCESSION   NM_001436476 XM_008766445
VERSION     NM_001436476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Hayakawa,T., Zhang,F., Hayakawa,N., Ohtani,Y., Shinmyozu,K.,
            Nakayama,J. and Andreassen,P.R.
  TITLE     MRG15 binds directly to PALB2 and stimulates homology-directed
            repair of chromosomal breaks
  JOURNAL   J Cell Sci 123 (Pt 7), 1124-1130 (2010)
   PUBMED   20332121
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Tominaga,K., Kirtane,B., Jackson,J.G., Ikeno,Y., Ikeda,T.,
            Hawks,C., Smith,J.R., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     MRG15 regulates embryonic development and cell proliferation
  JOURNAL   Mol Cell Biol 25 (8), 2924-2937 (2005)
   PUBMED   15798182
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Tominaga,K., Magee,D.M., Matzuk,M.M. and Pereira-Smith,O.M.
  TITLE     PAM14, a novel MRG- and Rb-associated protein, is not required for
            development and T-cell function in mice
  JOURNAL   Mol Cell Biol 24 (19), 8366-8373 (2004)
   PUBMED   15367658
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_008766445.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2807042.1,
                                           SRR26360194.1688690.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000008.1  99544152-99544332   c
            182-228             JAXUCZ010000008.1  99539758-99539804   c
            229-296             JAXUCZ010000008.1  99536696-99536763   c
            297-413             JAXUCZ010000008.1  99533558-99533674   c
            414-500             JAXUCZ010000008.1  99532310-99532396   c
            501-581             JAXUCZ010000008.1  99530685-99530765   c
            582-607             JAXUCZ010000008.1  99528916-99528941   c
            608-696             JAXUCZ010000008.1  99528426-99528514   c
            697-798             JAXUCZ010000008.1  99527621-99527722   c
            799-887             JAXUCZ010000008.1  99526363-99526451   c
            888-1060            JAXUCZ010000008.1  99525667-99525839   c
            1061-1145           JAXUCZ010000008.1  99524785-99524869   c
            1146-1878           JAXUCZ010000008.1  99522801-99523533   c
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1878
                     /gene="Morf4l1"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
     exon            1..181
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Morf4l1"
                     /note="upstream in-frame stop codon"
     CDS             142..1230
                     /gene="Morf4l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; transcription factor-like protein MRG15"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform 1"
                     /protein_id="NP_001423405.1"
                     /db_xref="GeneID:300891"
                     /db_xref="RGD:1307938"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKKSAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVL
                     KYVDANLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNG
                     DGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQK
                     QLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKF
                     ERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFL
                     KYLAKNSATLFSASDYEVAPPEYHRKAV"
     misc_feature    184..471
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    184..471
                     /gene="Morf4l1"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; Region:
                     CBD_MSL3_like; cd18983"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,415..417,
                     421..432,436..444,451..456)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(202..207,217..228,271..273,277..288,415..417,
                     421..432,436..444,451..456)
                     /gene="Morf4l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,415..417)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(217..219,277..279,286..288,415..417)
                     /gene="Morf4l1"
                     /note="putative methylated histone tail binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,412..426)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,274..291,412..426)
                     /gene="Morf4l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,412..414,424..426)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    order(268..270,277..279,289..291,412..414,424..426)
                     /gene="Morf4l1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350846"
     misc_feature    667..1194
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     misc_feature    667..1194
                     /gene="Morf4l1"
                     /note="Region: MRG; pfam05712"
                     /db_xref="CDD:461721"
     exon            182..228
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..296
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..413
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..500
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..581
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..607
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..696
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..798
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..887
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1060
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1145
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1878
                     /gene="Morf4l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggcgct ggcaaatcgc gcccaggatg tagagctggc tgttcccgac ggcgcgtctg
       61 acgctaaatt gggtggggta gagagtaggg ggcggtagtc gggggtggtg ggagaaggag
      121 gaggcggcga atcacttata aatggcgccc aagcaggacc cgaagcctaa attccaggag
      181 ggcgagcgag tgctgtgctt tcatgggcct cttctttatg aagcaaagtg tgtaaaggtt
      241 gccataaagg acaaacaagt gaagtatttt atccattaca gtggctggaa taaaaaaagt
      301 gctgtgaggc ccaggcgctc tgaaaaatct ttgaagacac gtgaggatat tgtagccctt
      361 tttcctgttc ctgaaggagc tccctcagta caccaccccc tcctgacctc tagttgggat
      421 gaatgggtgc cagaaagcag agtgctcaaa tacgtggacg ccaatttgca gaaacagcgg
      481 gaacttcaaa aggccaacca ggaacaatat gcagagggca agatgagagg ggctgctcca
      541 gggaagaaga catccggtct gcaacagaaa aatgttgaag tgaaaacaaa aaagaacaaa
      601 cagaaaacac ctggaaatgg agatggtggc agtaccagtg agacccctca gcctcctagg
      661 aagaagcgag cccgggtaga tccaaccgtt gaaaatgaag aaacattcat gaacagagtt
      721 gaagttaaag tgaagattcc tgaggagctg aaaccatggc ttgtagatga ctgggacttg
      781 atcaccagac aaaagcagct tttttatctt cctgccaaga agaatgtgga ttccattttg
      841 gaggattatg caaactataa gaagtctcga ggaaatacag ataataagga gtatgctgtt
      901 aatgaggttg tggcagggat aaaggagtac ttcaatgtaa tgttgggcac tcagctactc
      961 tacaaatttg agagaccaca gtatgctgaa attctggccg atcacccgga tgcacccatg
     1021 tcccaggtgt atggagcgcc acacttactg agattgtttg tgcgaattgg agcgatgttg
     1081 gcctatacac ctctagatga gaaaagcctt gctttattac tgaactatct acatgatttc
     1141 ctcaagtacc tggcaaagaa ttctgcaact ctgttcagtg ccagtgatta tgaagtggct
     1201 cctcctgagt accatcggaa agccgtgtga ggagtgtgct ctctcactcg tgcttggatc
     1261 tctgtaaaca gtttggttct tagtccttct cttgtacaaa tgatgtactt tgaagaccgt
     1321 tagtgtataa cagagttgat gtttgtttcc tgtttgattt taaacagaga aaataaaagg
     1381 agttaactgc tccttttttc tttctttttt tcatttcaaa gtttctacca gtgtatcagt
     1441 gatggacaac ggagagacat gctgtagagt gtttgcctag ttgacaaagc tgcttttgaa
     1501 tgctggtggt tctgttcctt tgacactacg cacttttata atatgtgtta atgctctatg
     1561 acaaaatgct ctgactccta gtgccaaagg ttcccttcag tgtgtataac tgaacactca
     1621 tccatctgtg ctcttttttt ttttaaatgg tgcttaaaga gcccatcctt tgcaagtcat
     1681 ccatgttgtt ccttaggcat tttatctttg ctcaattgtt aaagaatggt ggcttgtttt
     1741 catggttttt gtatttgtgt ctaatgcacg ttttaacatg atagacgcaa tgcatcgtgt
     1801 agctacagtt ttatggaaaa gtcaatcttg taggagttgt ttttcagatc ttcaataaat
     1861 tttttcttta aatttcaa
//
LOCUS       NM_001436465            3711 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus IQ motif containing H (Iqch), transcript variant
            1, mRNA.
ACCESSION   NM_001436465 XM_008766237
VERSION     NM_001436465.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_008766237.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.45840.1,
                                           SRR26360181.1283398.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000008.1  72978476-72978591   c
            117-239             JAXUCZ010000008.1  72965283-72965405   c
            240-328             JAXUCZ010000008.1  72964734-72964822   c
            329-443             JAXUCZ010000008.1  72954872-72954986   c
            444-560             JAXUCZ010000008.1  72940310-72940426   c
            561-681             JAXUCZ010000008.1  72914785-72914905   c
            682-810             JAXUCZ010000008.1  72911713-72911841   c
            811-932             JAXUCZ010000008.1  72901945-72902066   c
            933-971             JAXUCZ010000008.1  72900132-72900170   c
            972-1523            JAXUCZ010000008.1  72891516-72892067   c
            1524-1590           JAXUCZ010000008.1  72890677-72890743   c
            1591-1674           JAXUCZ010000008.1  72879267-72879350   c
            1675-1850           JAXUCZ010000008.1  72875386-72875561   c
            1851-2123           JAXUCZ010000008.1  72866121-72866393   c
            2124-2315           JAXUCZ010000008.1  72861335-72861526   c
            2316-2436           JAXUCZ010000008.1  72848274-72848394   c
            2437-2723           JAXUCZ010000008.1  72845413-72845699   c
            2724-2894           JAXUCZ010000008.1  72819954-72820124   c
            2895-3017           JAXUCZ010000008.1  72811070-72811192   c
            3018-3079           JAXUCZ010000008.1  72795168-72795229   c
            3080-3188           JAXUCZ010000008.1  72791557-72791665   c
            3189-3711           JAXUCZ010000008.1  72787701-72788223   c
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3711
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ motif containing H"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
     exon            1..116
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    6..8
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="upstream in-frame stop codon"
     CDS             66..3323
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein H"
                     /codon_start=1
                     /product="IQ domain-containing protein H isoform 1"
                     /protein_id="NP_001423394.1"
                     /db_xref="GeneID:300776"
                     /db_xref="RGD:1310670"
                     /translation="MAQAQELNDPIGSILIQVHGDLHQLKEKLIQFSAEETRDPLDIQ
                     NLETAIQRTETGLKIHIERYLGIVNQEVIMTPVKSLDSPINSKWAIPTVIDQKSFIFP
                     MAPDKLWGLQKHRGSLPRGFTRAKPKVELNKKIMQDPENMHHRAAVNVSYGISLPRIK
                     QRKAHDKVRRVRKGSTISNLTVLPSSHRTDPHFIPIPVLQKDASKGILSMIERGLIPP
                     AARITFQNPPIKPQALPLHSFDEHRKVSITASFPIAHKPRLASEKVEESQQKQKAKVL
                     THLSTEEHSLPVTGKDKRSRGQPSRKSTRITTPSRIRRSPWDYILPVYNGSVDRAAPD
                     FIAFKTRYKLIWGSIFSFLEQIEKFLKDYAISEAKVRGKSLVSLLPEFELNNKLTKTD
                     VLAVLENPLHIQMLLNLPGQRFKGRDGRTEAAVKIQATWKSYKARTSFISYRQKKWAS
                     GVIALAWLLHCHKTRLKRIVEESRQRHLDNFRIRAKHLAANWSRIRTSRRTIIHIPSL
                     GYSQSVRKHISDLDIEQNRQLGRLCDILDVNVNVIYVCSSPMNDELKLYYKKLLSLQA
                     AVKSGYYGDRSDLQNRFRIITPEAVNIFTKHHMCLATHLMYSPKAIKRIKNLIQGEEA
                     YIVGGILHRDDLAVADMLNVPILASEPELVHLYSGKSGSKRIFDNANVPMPPGVYDIY
                     TYQQLIEQLSQLVTDNLGIRRWVFKMNMEFGGNGTAFCDIPSHLQCYKWVVKESNRFG
                     PEDWKKKWAQESALMKISEELAGVLAQHVQLVNEKQFPTWRKFLHMFLTQGGIIEAYP
                     PADSITNLTVDMLIEPDGEVRVLSMGDQFHADGPFISSGTTMPQTSVDPQVLNSLCLR
                     IGNICKEKDVVGYFSIDLVTFIDPSTLEQQVWTTGLNLSYSDQLAMTQLTLYLTNGYL
                     NCSLSTLEVPRFKEDAEREKKRLSIQAELAPETSRYAVMSTQLKHDNLSLIFYYVFLQ
                     MCKAHGIGYDLEDRQGTVFILYESLKRYKLGMITIGVDLQGALMTFARNLFIIHQEIS
                     APDMQGETNFKTTIDDIETILGVTEENKMIFAGEKRRKEEEESLYEPVEIYTKTV"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1323..1406
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     exon            117..239
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            240..328
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            329..443
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            444..560
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            682..810
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            811..932
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            933..971
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1523
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1590
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1674
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1850
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2123
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2315
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2436
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2723
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2894
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3017
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3079
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3188
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3711
                     /gene="Iqch"
                     /gene_synonym="RGD1310670"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctagaa gcgctccgga gaaggccata cctccggagc caagcgcctt ctgcctgcct
       61 cagtcatggc tcaggcccag gagctcaacg accccattgg atccatccta atccaggtcc
      121 atggggacct ccatcagtta aaggagaaat taattcaatt ctcagctgag gagacaagag
      181 accctctaga cattcaaaat cttgagacag caattcaaag aactgaaacg gggttaaaga
      241 ttcacattga gaggtatctc ggaattgtaa accaggaggt gataatgact cctgtgaaga
      301 gcttagactc ccctatcaat tccaaatggg cgattccaac tgtaattgac cagaaatcct
      361 ttatttttcc catggctccc gataaacttt ggggacttca aaaacatcgc ggttcacttc
      421 cacgcggctt tacaagagca aagccaaaag tagagttgaa caagaagatc atgcaggacc
      481 ctgagaacat gcaccacaga gctgctgtaa atgtgagcta tgggatcagt ttgccacgta
      541 ttaaacagag gaaagcacat gataaggttc ggcgggtaag aaaagggtcc acgatctcca
      601 acctcacagt tctgccatcc agtcatcgca ctgaccccca ttttatcccc atacctgtct
      661 tgcaaaagga tgccagtaaa gggatcttaa gtatgatcga acgagggctg atccccccag
      721 cagcaaggat tacctttcag aatccaccca ttaaacccca agcacttcct ctgcatagct
      781 ttgatgagca tcggaaggta tcaataacag cctcctttcc gatagctcat aagccacgcc
      841 tggcttcaga aaaagtggag gagtctcaac agaaacagaa agccaaggta ctcacacatc
      901 taagcacgga agaacacagt ctacctgtga cgggaaaaga caaaaggtca agaggacaac
      961 ccagtaggaa gagcacgagg attactacac cgtctaggat taggagatca ccatgggatt
     1021 acatcttgcc tgtttacaac ggctctgtag acagggcagc cccagacttt atagcattca
     1081 aaacacgtta caaattaatc tggggaagca ttttttcttt cctggaacaa attgagaaat
     1141 ttctcaagga ctatgcaata tcagaagcca aagtaagagg gaagagtctg gtgtccctgc
     1201 ttccagagtt tgagctgaac aacaaactta ccaaaactga cgttctggct gtgctagaga
     1261 acccgctcca catccagatg ctgctaaatc ttcctggaca gaggttcaag ggccgggacg
     1321 gaaggacaga ggctgccgtc aagatccaag ccacatggaa aagttataag gcaagaactt
     1381 ccttcatttc ttatcgccag aagaagtggg cctcgggagt gatcgccctg gcatggcttc
     1441 tacattgcca caaaacaaga ctaaagagga tagtggagga atctcgacag agacacctgg
     1501 ataacttccg aattcgagcc aagcatctgg cagccaactg gagtcgcatc aggacctcca
     1561 ggaggactat tatccatata ccatcattag gatattccca gtctgtgcga aaacacatat
     1621 ctgatttgga catagagcag aacaggcagt tggggaggct gtgtgacatc ctagatgtca
     1681 acgtcaatgt catctacgtc tgctccagtc ccatgaatga cgagttaaag ctgtactaca
     1741 aaaaactcct gagtctgcaa gcagctgtca aatcgggcta ctatggggat aggtctgacc
     1801 tgcaaaacag gttcagaatt atcacccctg aagctgtaaa catcttcact aaacatcaca
     1861 tgtgcctggc tactcacctg atgtacagtc ccaaggcaat caaaagaata aaaaatctca
     1921 tccaaggaga agaggcctac atcgtgggcg ggatcctcca cagagatgat ttagctgtgg
     1981 ctgacatgtt gaatgtaccc atcctggcct cagagcctga gctggttcac ctttacagtg
     2041 gcaagtctgg aagtaaacgg atctttgata acgctaatgt gccaatgcct cctggagtat
     2101 atgacatcta tacttaccag cagctgatag aacaattgag tcagttggtg actgataacc
     2161 tgggaatccg acgctgggtc tttaaaatga acatggaatt tggaggaaat gggacagcat
     2221 tttgcgacat cccttcccat ctacagtgct acaaatgggt ggtgaaggag agtaacagat
     2281 tcggccctga ggactggaag aagaagtggg cacaagagtc agctctgatg aagatctccg
     2341 aggagctggc gggcgtttta gcacagcacg tacagctagt caatgagaaa cagttcccga
     2401 catggagaaa attcctccac atgtttctca ctcaaggtgg catcattgaa gcatacccac
     2461 ctgcagacag catcaccaac ctcaccgtag acatgttgat agagcctgac ggagaagtca
     2521 gagtgctgtc aatgggggac cagtttcatg ctgatggccc ctttatttct tctggtacca
     2581 ccatgcctca gacttcagtg gatccccaag ttctcaattc tttgtgcctc cgaattggaa
     2641 atatctgcaa agagaaagat gtggttggtt atttttctat agatctggtg acttttattg
     2701 atccaagcac cttagagcag caggtatgga caacaggcct caacctctca tacagtgacc
     2761 agctagccat gacgcagctc accctgtacc tgacaaatgg ttatctgaat tgtagtctga
     2821 gcaccctgga agtgccccgt tttaaagaag atgcagaaag ggaaaagaaa cgtctgagca
     2881 tccaggcaga gctggcccca gaaaccagtc gctatgcagt gatgtccaca cagctgaagc
     2941 acgacaatct ctcactcatc ttctattatg tttttctcca gatgtgtaag gcccatggca
     3001 tcggctatga ccttgaggac agacaaggaa ctgtttttat attatatgaa tctctgaaga
     3061 gatacaagtt gggcatgata acaatcggtg tggatctcca gggggccctc atgacctttg
     3121 ctcgcaatct cttcatcatc catcaagaaa tatcagcacc tgatatgcaa ggcgagacca
     3181 attttaagac taccattgat gatattgaaa ccattttagg agtaacagaa gaaaataaaa
     3241 tgatatttgc aggagaaaaa cggcgcaaag aggaggaaga gagcctgtat gagcctgttg
     3301 agatatacac aaaaacagta tgactttgga tacctgtcta aagcgagaaa aaaggtttgc
     3361 tttgtaatta atgtaaaagt gaggaagtta gtttgctttg tttgccaaga gataaatcag
     3421 aacaaattgt aacataatag tctttaaaat ctttgcttat tttccagtgt tattttactc
     3481 attaaggtta aacctaccgg tgttttcatt gtgagtgcta agaatccctt cctcctcccc
     3541 aaaacaaaga agccagagga aggctttggc ccactactgc tccacttctt ttctcctgct
     3601 tccaaaagcc acttagggtc ttcatttaaa ataccaaata aaccagagtg atcacttgtc
     3661 aaaacacaaa tgtcctcttt tcccaaaata aatgaaatca gttttaaatg a
//
LOCUS       NM_001106872            2409 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus chemokine (C-C motif) receptor 1-like 1 (Ccr1l1),
            mRNA.
ACCESSION   NM_001106872 XM_001078798 XM_039081322 XM_236742
VERSION     NM_001106872.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 13, 2025 this sequence version replaced
            XM_039081322.2, NM_001106872.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680413,
                              SAMN06680416 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000008.1  132478351-132478489 c
            140-244             JAXUCZ010000008.1  132477112-132477216 c
            245-2409            JAXUCZ010000008.1  132467425-132469589 c
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2409
                     /gene="Ccr1l1"
                     /note="chemokine (C-C motif) receptor 1-like 1"
                     /db_xref="GeneID:301088"
                     /db_xref="RGD:1308007"
     exon            1..139
                     /gene="Ccr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..244
                     /gene="Ccr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..2409
                     /gene="Ccr1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    291..293
                     /gene="Ccr1l1"
                     /note="upstream in-frame stop codon"
     CDS             312..1382
                     /gene="Ccr1l1"
                     /codon_start=1
                     /product="C-C chemokine receptor 1-like protein 1"
                     /protein_id="NP_001100342.1"
                     /db_xref="GeneID:301088"
                     /db_xref="RGD:1308007"
                     /translation="MESPAVTESSYNTVAMNDFFSGFVCFSINVRAFGITVLTPLYSL
                     VFVIGVIGNVLVVLVLIQRKRLRNMTSIYLFNLAVSDLVFLFTLPFWVDYIVKGDWVF
                     GNAMCKFLAGFYYLGLYSDMFFITLLTIDRYLAVVHAVFALRARTVTFGIISSIITWV
                     LATLVSIPCLYFFKTQLEFTYQTCRAVLPKKSLIQFLRFQALTMNILGLILPLLAMII
                     CYTRIINVLHRRPNKKKAKVMRLIFVITLLFFLLLTPYYLAAFVSAFEDVLFTPGCVR
                     SQQVDLALMITEALAYTHCCVNPVIYVFVGERFRKYLRQLFWRRTAVSLPKWLPFHSV
                     DRVQRSSSTSPSTGEIEVSADL"
     misc_feature    417..1250
                     /gene="Ccr1l1"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    417..1250
                     /gene="Ccr1l1"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    423..497
                     /gene="Ccr1l1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320311"
     misc_feature    423..497
                     /gene="Ccr1l1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320311"
     misc_feature    522..587
                     /gene="Ccr1l1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320311"
     misc_feature    522..587
                     /gene="Ccr1l1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320311"
     misc_feature    633..701
                     /gene="Ccr1l1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320311"
     misc_feature    633..701
                     /gene="Ccr1l1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320311"
     misc_feature    768..818
                     /gene="Ccr1l1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320311"
     misc_feature    768..818
                     /gene="Ccr1l1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320311"
     misc_feature    903..974
                     /gene="Ccr1l1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320311"
     misc_feature    903..974
                     /gene="Ccr1l1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320311"
     misc_feature    1026..1094
                     /gene="Ccr1l1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320311"
     misc_feature    1026..1094
                     /gene="Ccr1l1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320311"
     misc_feature    1152..1229
                     /gene="Ccr1l1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320311"
     misc_feature    1152..1229
                     /gene="Ccr1l1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320311"
ORIGIN      
        1 gtattagcag tttactgaat tttctttcag agataccgga aatactccag gagggaacat
       61 gcacagaaac gcactgaaga atcccattgc acttgagcat ttttctagtc ttttattcta
      121 ttttgagtct ggatataagg tctcgatgga ggacacacgc acttcagaga catgacatac
      181 ttggagtaaa gggaagcaga caccagctac atcaggatcc aggtatatca cagatagttt
      241 tcagaggcct acgtgtttaa tagcaaagaa aatataaagg tcattgtctg tgacctgtag
      301 aagagtttac aatggagagt ccagctgtca cagagtcctc ctataacaca gttgccatga
      361 atgacttctt ttctggattc gtatgtttca gcataaatgt gcgggcattt ggaatcacag
      421 tgctgactcc gctgtactcg ctggtgtttg tcattggtgt gataggcaat gtcctggtgg
      481 ttctggtgct catacaacgc aagaggcttc gaaacatgac cagcatctac ctgttcaacc
      541 tggctgtctc tgatctggtc tttctattca cactaccttt ctgggttgac tatatcgtaa
      601 aaggagactg ggtgtttggt aatgccatgt gtaagtttct cgctggattt tattacctgg
      661 gcttgtatag tgacatgttt tttatcaccc tgcttacaat tgataggtac ctagctgttg
      721 tccatgctgt gtttgctctg agggcccgga ctgtcacttt tggcatcatc agcagcatca
      781 ttacctgggt cctagctacc ttggtttcta ttccttgtct gtattttttc aaaactcagt
      841 tggagttcac ttaccaaacc tgcagagcag ttttgcccaa gaagagcctg atacagtttt
      901 tgaggtttca ggctctcaca atgaacatcc ttgggctaat tttgcctctg ttggccatga
      961 tcatctgcta tacaaggatc atcaatgttc tacacagaag acccaataag aagaaggcca
     1021 aagtcatgcg tctgattttt gttattacac ttctcttctt cctcctcttg accccctatt
     1081 atttggctgc ctttgtttct gcttttgaag acgtcctatt cacccccggg tgtgtgagaa
     1141 gccaacaggt ggacctggcc ttgatgataa ctgaggcact tgcctacacc cactgctgtg
     1201 tcaacccagt catttatgtc tttgtgggtg aacggttccg gaagtacctc cggcagctgt
     1261 tttggaggcg tacagctgta tccctgccaa aatggctgcc cttccactcg gtagaccgag
     1321 tacagaggtc cagttccacg tctccatcca caggggaaat tgaggtctct gctgacttat
     1381 aattcagact cctggatgcc aacaaagacc aagaagagag tgaaaagaca gtgtgcctct
     1441 ctaagacaga tacgaaccga ggattcattt tcttgtaaaa cagaggaacc ttgcaggtag
     1501 cttagataga atgtttgcca tgatcttctt cctgtcggaa agggtatgta tgaacaaatt
     1561 gagacattcc agagactggg acagtaggtt ccagggaaga agggctcaga cccaatagga
     1621 ggtagggttt gtgcccaata gcattggcaa acaaagtgaa ccccactccc agtgattatg
     1681 gaaccagttg agtacacaat cgtgtgtact ctgaacctga aagtcaacgg cagttcacag
     1741 atgcctcctc taccacaccc acactgcagg acttgaactc ttaaaaacct ggaactctag
     1801 atcaaagtag ttgagaccta ttgaggcact gcattccatt tgagtaggaa agtctttaga
     1861 aagaatttat atttgttaaa accaaagatt tctggcaagt aaatagagaa gaatatttac
     1921 cttccctgct tgtagtcttc tccctaaagg atcaggcctc taagaatata gtataatata
     1981 atataatatg tattttgtat tatatttatt atattacatt aacctccacc tcacctttct
     2041 aatcctgcag gttctatgta tctaatctgg agtaatactt ttcagtgctt tgtcttatat
     2101 taacagcaag gtaaatatgt gctgtgtgaa atgcactctg gaataatttt atcatgctca
     2161 aatatggaaa ttggtttact tggtattccc atttttagtg gctgccatct gcttaccttg
     2221 ggagacttta ctgggtttga taactccatt tactaatttt tatatcatgc tggaaagaga
     2281 taaacttgta ttttgtagtg ctttattccc tacaatgact tcttttcctg taatacctac
     2341 attttcactt gtcttactct atgttgaata gaaatcctta attttggtgt aataaatttc
     2401 atcaactcc
//
LOCUS       NM_001436504            4453 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 28 (Usp28),
            transcript variant 1, mRNA.
ACCESSION   NM_001436504 XM_006243006
VERSION     NM_001436504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4453)
  AUTHORS   Hao,X., Ma,C., Chen,S., Dang,J., Cheng,X. and Zhu,D.
  TITLE     Reverse the down regulation of miR-92b-3p by hypoxia can suppress
            the proliferation of pulmonary artery smooth muscle cells by
            targeting USP28
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3064-3077 (2018)
   PUBMED   30149918
  REMARK    GeneRIF: miR-92b-3p reverse the proliferaton of pulmonary artery
            smooth muscle cells under hypoxia condition. miR-92b-3p regulate
            the protein level of USP28.
REFERENCE   2  (bases 1 to 4453)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4453)
  AUTHORS   Bassermann,F., Frescas,D., Guardavaccaro,D., Busino,L.,
            Peschiaroli,A. and Pagano,M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   4  (bases 1 to 4453)
  AUTHORS   Popov,N., Herold,S., Llamazares,M., Schulein,C. and Eilers,M.
  TITLE     Fbw7 and Usp28 regulate myc protein stability in response to DNA
            damage
  JOURNAL   Cell Cycle 6 (19), 2327-2331 (2007)
   PUBMED   17873522
REFERENCE   5  (bases 1 to 4453)
  AUTHORS   Popov,N., Wanzel,M., Madiredjo,M., Zhang,D., Beijersbergen,R.,
            Bernards,R., Moll,R., Elledge,S.J. and Eilers,M.
  TITLE     The ubiquitin-specific protease USP28 is required for MYC stability
  JOURNAL   Nat Cell Biol 9 (7), 765-774 (2007)
   PUBMED   17558397
REFERENCE   6  (bases 1 to 4453)
  AUTHORS   Zhang,D., Zaugg,K., Mak,T.W. and Elledge,S.J.
  TITLE     A role for the deubiquitinating enzyme USP28 in control of the
            DNA-damage response
  JOURNAL   Cell 126 (3), 529-542 (2006)
   PUBMED   16901786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006243006.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.31580.1,
                                           SRR26643296.21683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000008.1  58222328-58222488
            162-239             JAXUCZ010000008.1  58237749-58237826
            240-372             JAXUCZ010000008.1  58238699-58238831
            373-478             JAXUCZ010000008.1  58240118-58240223
            479-638             JAXUCZ010000008.1  58240929-58241088
            639-725             JAXUCZ010000008.1  58246791-58246877
            726-863             JAXUCZ010000008.1  58247452-58247589
            864-937             JAXUCZ010000008.1  58248648-58248721
            938-1017            JAXUCZ010000008.1  58249615-58249694
            1018-1166           JAXUCZ010000008.1  58254695-58254843
            1167-1294           JAXUCZ010000008.1  58256533-58256660
            1295-1390           JAXUCZ010000008.1  58258205-58258300
            1391-1570           JAXUCZ010000008.1  58264169-58264348
            1571-1794           JAXUCZ010000008.1  58266333-58266556
            1795-1865           JAXUCZ010000008.1  58267575-58267645
            1866-2094           JAXUCZ010000008.1  58268925-58269153
            2095-2286           JAXUCZ010000008.1  58271693-58271884
            2287-2426           JAXUCZ010000008.1  58273167-58273306
            2427-2606           JAXUCZ010000008.1  58273482-58273661
            2607-2702           JAXUCZ010000008.1  58274560-58274655
            2703-2881           JAXUCZ010000008.1  58276058-58276236
            2882-2960           JAXUCZ010000008.1  58276347-58276425
            2961-3040           JAXUCZ010000008.1  58277395-58277474
            3041-3164           JAXUCZ010000008.1  58277966-58278089
            3165-3360           JAXUCZ010000008.1  58279354-58279549
            3361-4453           JAXUCZ010000008.1  58281608-58282700
FEATURES             Location/Qualifiers
     source          1..4453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4453
                     /gene="Usp28"
                     /note="ubiquitin specific peptidase 28"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
     exon            1..161
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3536
                     /gene="Usp28"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin thioesterase 28; deubiquitinating enzyme 28;
                     ubiquitin-specific-processing protease 28; ubiquitin
                     thiolesterase 28; ubiquitin specific protease 28;
                     ubiquitin carboxyl-terminal hydrolase 28"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 28 isoform
                     1"
                     /protein_id="NP_001423433.1"
                     /db_xref="GeneID:315639"
                     /db_xref="RGD:1311555"
                     /translation="MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEAL
                     KASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDL
                     QAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGW
                     PVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQEL
                     QYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVN
                     VNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQVNGYHNLDECLEGA
                     MVEGDIALLPSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQV
                     IYMDRYMYKSKELIRSKRESIRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVI
                     EFASTKPASESCLSGSVEHMTLPLPSVHCPISDLTAKESSSPKSCSQNAEGSFSSPED
                     ALPNSEVMNGPFTSPHSSLEMPAPPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLK
                     NCISSTTQAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQIWLKYND
                     ISVTESSWEELERDSYGGLRNVSAYCLMYINDKLPHCSAEAAHGESDQTAEVEALSVE
                     LRQYIQEDNWRFEQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESSAASSHGVRCL
                     SSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEHKEAEPEKPQETNLAEQSEQAAEV
                     KDTEAAAPPNSEVSEVEIPSVGRILVRSDADGYDEEVMLSPAMQGVLLAIAKARQTFD
                     RDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRVVERTLLE
                     QFADRNLSYDERSISIMKVAQAKLMEIGPEDMNMEEYKRWHEDYSLFRKVSVYLLTGL
                     ELFQKGKYQEALSYLVYAYQSNAGLLVKGPRRGVKESVIALYRRKCLLELNAKAASLF
                     ETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENL
                     QLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    171..296
                     /gene="Usp28"
                     /note="UBA domain found in ubiquitin carboxyl-terminal
                     hydrolase 28 (UBP28) and similar proteins; Region:
                     UBA_UBP28; cd14355"
                     /db_xref="CDD:270540"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..2066
                     /gene="Usp28"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19I; cd02665"
                     /db_xref="CDD:239130"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    591..>917
                     /gene="Usp28"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cl02553"
                     /db_xref="CDD:470612"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    order(600..602,615..617,1920..1922,1974..1976)
                     /gene="Usp28"
                     /note="active site"
                     /db_xref="CDD:239130"
     misc_feature    2694..3533
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     misc_feature    2694..3533
                     /gene="Usp28"
                     /note="carboxyl-terminal domain of ubiquitin-specific
                     protease 28 (USP28); Region: USP28_C; cd20487"
                     /db_xref="CDD:380452"
     exon            162..239
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            240..372
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..638
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            726..863
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1166
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1294
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1390
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1570
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1794
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1865
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2094
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2286
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2426
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2606
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2702
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2881
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2960
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3040
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3164
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3360
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..4453
                     /gene="Usp28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctccc ggtactccgg ggcttcgggg gcggcggtgg tggcggtggt gaccgcggcg
       61 aagacgacaa cgagagtggg gctacacgcg gaggcaccac ggccatgact gcggagctgc
      121 agcaggacga cgcggcgggg gcggcggacg gccatggctc gagctgccag atgctgttaa
      181 atcagctgcg agaaatcacg ggcatccagg atccttcctt tcttcatgaa gcattaaagg
      241 ccagtaatgg tgacatcacc caggctgtca gccttctcac agaccaaaga gttaaggagc
      301 ccagtcacga cacagctgct acagaaccat ctgaagtaga agagagtgct accagcaaag
      361 atctcttagc aaaagtgata gaccttacac atgacaacaa agatgacctt caggcagcca
      421 ttgccttgag tctcctggag tctcctaaca ttcagactga cagcagagat cttaatagaa
      481 tacatgaagc taactctgca gagactaaac gatcaaagag aaaacgctgt gaagtttggg
      541 gagaaaacca caatcccaat aactggagga gagtggatgg ttggccagtt gggctgaaaa
      601 atgttggcaa cacatgttgg ttcagtgctg ttattcagtc tctctttcag ttgcctgaat
      661 ttcgaagact tgttctcagt tacagcctgc cacagaacat tcttgaaaat tgtcgaagtc
      721 acactgaaaa aagaaatatc atgtttatgc aagagcttca gtatttattt gctctgttat
      781 tgggatcaaa tcggaaattt gtagatcctt ctgctgccct ggatctactg aagggggcct
      841 tccgatcctc agaggagcaa cagcaagatg tgagtgaatt cacacacaag ctcctggatt
      901 ggctggagga tgcgttccag ctagctgtta atgttaacag caatcccagg actaaatctg
      961 aaaaccccat ggtgcagctg ttctacggta ccttcctgac agaaggggtc cgagaaggaa
     1021 aacccttttg taacaacgag accttcggcc agtaccctct tcaggtaaac ggttaccaca
     1081 acttagacga gtgtttggaa ggggccatgg tggaaggtga cattgcgctg cttccttctg
     1141 atcgctcagt gaaatacgga caagagcgtt ggtttacaaa gctgcctcca gtgttgacct
     1201 tcgaactctc cagatttgag tttaatcagt ctcttgggca gcctgagaaa attcataata
     1261 agctggaatt tcctcaggtt atttatatgg ataggtacat gtacaaaagc aaagagctta
     1321 tccgaagtaa gagagagagc attcgaaagt tgaaggagga aatacaagtt ctgcagcaga
     1381 aattagaaag gtatgtgaag tacggctccg gtccatctcg cttcccactc cccgacatgt
     1441 tgaaatacgt tattgaattt gccagtacaa aacctgcctc tgaaagctgt ctgtctggaa
     1501 gtgttgagca tatgacgtta ccacttcctt ctgtgcactg cccgatttct gacctcacag
     1561 ccaaggaaag ttcaagtccc aaaagctgct ctcagaatgc tgagggttcc ttttcctctc
     1621 cggaagatgc tctacccaac tctgaggtaa tgaatgggcc atttacttct cctcactctt
     1681 ccctggaaat gcctgcaccc ccaccagctc ctcggacagt cacagatgag gaaatgaatt
     1741 tcgttaagac ctgtcttcag aggtggcgga gtgaaattga acaggatata caagacttaa
     1801 agaattgtat ctcgagcacc acccaggcta ttgagcagat gtactgtgat cctcttcttc
     1861 gtcaggtgcc ttatcgctta catgcagttc ttgttcatga aggacaagcc agtgcagggc
     1921 actactgggc gtacatctat aaccagcccc ggcagatctg gctcaaatac aacgacatct
     1981 ctgtcactga gtcttcctgg gaagaacttg aaagagattc ttacgggggc ctgagaaatg
     2041 tcagcgcata ctgcttgatg tatatcaatg acaagttgcc ccactgcagt gcagaggcag
     2101 cgcatggtga atctgatcag actgcagaag tggaagccct gtctgtggaa ctcaggcagt
     2161 acattcagga agataactgg aggtttgagc aagaggtgga ggaatgggag gaagaacagt
     2221 cctgtaagat cccacagatg gagtcctccc caaactcttc ctcacaggat ttttccacat
     2281 cacaagagtc ttcagcagcg tcctcgcatg gcgttcgatg tttgtcttct gaacatgctg
     2341 tgattgcaaa ggagcagact gcccaggcca tcgcaaacac ggctcatgcc tatgagaaga
     2401 gcggggtaga agcagccttg agtgagcata aggaagctga acccgagaag ccccaggaaa
     2461 caaaccttgc agagcagtca gaacaggctg cagaggtcaa agacacagag gctgctgccc
     2521 cacctaactc tgaggtctct gaagtggaga tccccagtgt gggaaggatt ctggttagat
     2581 ctgatgcaga tggctatgat gaggaggtga tgctgagccc tgccatgcaa ggggtcctcc
     2641 tggccatagc taaggcgcgc cagacctttg accgagacgg gtctgaagca gggcttatta
     2701 aggcatttca tgaagagtac tccaggctct atcagcttgc caaagagaca cccacctctc
     2761 acagtgatcc tcgccttcag catgttctcg tctacttttt ccaaaatgaa gcacccaaga
     2821 gggtagtaga acgaaccctt ctggaacagt ttgcagatag aaaccttagc tatgatgaga
     2881 gatctatcag tatcatgaag gtggctcagg ccaaactgat ggaaattggt ccagaggaca
     2941 tgaacatgga agagtataag aggtggcatg aagactatag tctgttccga aaggtgtctg
     3001 tgtacctgct aacgggcctg gaactcttcc aaaaaggaaa gtaccaggaa gctttgtcct
     3061 acctggtgta cgcgtaccag agcaatgctg gcctgctggt gaaggggccc cgcaggggcg
     3121 tgaaggagtc tgtgattgct ttgtaccgca gaaaatgcct tctggagttg aatgccaagg
     3181 ctgcttctct ttttgaaaca aatgacgacc attctgtaac agagggcatt aatgtgatga
     3241 atgagctgat cattccctgc atccacctga tcattaataa tgacatttcc aaggacgacc
     3301 ttgatgccat cgaggtcatg aggaaccact ggtgctctta cctggggaag gacatcgcag
     3361 aaaatctgca gctgtgttta ggggagttcc tacccaggct tctagatcct tccgcagaaa
     3421 tcatcgtcct aaaggagcct ccaactattc gaccgaattc tccctatgat ctttgcagcc
     3481 ggtttgcagc tgtcatggag tccattcaag gagtttcaac agtaacagtg aagtaaactg
     3541 cacatggacg gtcaagactc attttggtct ccagtcacct gccagttaca cggcagtctg
     3601 ttgttgcaga ctcccctgga gagagagatt gggtgtctga gcaagattta gaccctctgc
     3661 cctctctgat atgtgtttaa gggattaagg ataaagttgc gcatttaggt acagaatcat
     3721 gagagctctc tcactgaaga aggcaggagc ccggtgcatt aaggttttga attatcccag
     3781 aagacctgaa ttgccttttt aaatctccca taataattac ccttcgggcg cctgtctcat
     3841 cagaactgag ccggaggaac agtttctggt tcttttgtca agttcaggtg acgtttctaa
     3901 gtccttagct accagagatt ggcaacaggg gccttgcctg gctcttgaca gtaacacaaa
     3961 gggtgctgct gagcctttcc ctccacacaa gggtagagcg taaggcttcg cccaccatga
     4021 agccacagga aagctgcctc cattttcggt ctgtttatat ttcagataaa ccagaaaacc
     4081 tcacactcag tcttgagtga aagagaagca agcatcctgg gctctcaccc cagtgctggt
     4141 gtaaagctgc acaagggaca tttaatagct aattaagcaa cattgtggag attgtcacat
     4201 gcaggtgtct aaggctacct ggcctgatag aattttgatt ctctctttcc tttttttttt
     4261 tttagaaata agggatgtga atttatatag agagagacca tctatctgtg tatatgtaga
     4321 gaagctgctt tttaaagaac ttttaattgg gaattcatgt tttaacaaaa ttttaaggat
     4381 taacgaggaa tcatgggagg gaagaacaca actatgcaga ttttataaat gtgcaataaa
     4441 agtatttgtt tta
//
LOCUS       NM_001436525            4325 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus cell adhesion molecule 1 (Cadm1), transcript
            variant 6, mRNA.
ACCESSION   NM_001436525 XM_039081722
VERSION     NM_001436525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Sun,S., Liu,W. and Li,Y.
  TITLE     CADM1 enhances intestinal barrier function in a rat model of mild
            inflammatory bowel disease by inhibiting the STAT3 signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 52 (5), 343-354 (2020)
   PUBMED   32929607
  REMARK    GeneRIF: CADM1 enhances intestinal barrier function in a rat model
            of mild inflammatory bowel disease by inhibiting the STAT3
            signaling pathway.
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Cao,W., Shi,P. and Ge,J.J.
  TITLE     miR-21 enhances cardiac fibrotic remodeling and fibroblast
            proliferation via CADM1/STAT3 pathway
  JOURNAL   BMC Cardiovasc Disord 17 (1), 88 (2017)
   PUBMED   28335740
  REMARK    GeneRIF: miR-21 overexpression promotes cardiac fibrosis via STAT3
            signaling pathway by decrease CADM1 expression, indicating miR-21
            as an important signaling molecule for cardiac fibrotic remodeling
            and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    GeneRIF: proteins. Our results highlight a previously unexplored
            role for MPP2 at postsynaptic sites as a scaffold that links
            SynCAM1 cell adhesion molecules to core proteins of the
            postsynaptic density.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Zhang,C., Caldwell,T.A., Mirbolooki,M.R., Duong,D., Park,E.J.,
            Chi,N.W. and Chessler,S.D.
  TITLE     Extracellular CADM1 interactions influence insulin secretion by rat
            and human islet beta-cells and promote clustering of syntaxin-1
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E874-E885 (2016)
   PUBMED   27072493
  REMARK    GeneRIF: Our results suggest that, as in the CNS, CADM1
            interactions drive exocytic site assembly and promote actin network
            formation. These results support the broader hypothesis that the
            effects of cell-cell contact on beta-cell maturation and function
            are mediated by the same extracellular protein interactions that
            drive the formation of the presynaptic exocytic machinery. These
            interactions may be therapeutic targets for re...
REFERENCE   5  (bases 1 to 4325)
  AUTHORS   Perez de Arce,K., Schrod,N., Metzbower,S.W.R., Allgeyer,E.,
            Kong,G.K., Tang,A.H., Krupp,A.J., Stein,V., Liu,X., Bewersdorf,J.,
            Blanpied,T.A., Lucic,V. and Biederer,T.
  TITLE     Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
  JOURNAL   Neuron 88 (6), 1165-1172 (2015)
   PUBMED   26687224
REFERENCE   6  (bases 1 to 4325)
  AUTHORS   Li,J., Zhang,Z., Bidder,M., Funk,M.C., Nguyen,L., Goodfellow,P.J.
            and Rader,J.S.
  TITLE     IGSF4 promoter methylation and expression silencing in human
            cervical cancer
  JOURNAL   Gynecol Oncol 96 (1), 150-158 (2005)
   PUBMED   15589594
REFERENCE   7  (bases 1 to 4325)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   8  (bases 1 to 4325)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   9  (bases 1 to 4325)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: a brain-specific, immunoglobulin domain-containing protein
            that binds to intracellular PDZ-domain proteins and functions as a
            homophilic cell adhesion molecule at the synapse (SynCAM; Synaptic
            cell adhesion molecule)
REFERENCE   10 (bases 1 to 4325)
  AUTHORS   Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
            Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
            Kitamura,T., Reeves,R.H. and Murakami,Y.
  TITLE     Promoter methylation of TSLC1 and tumor suppression by its gene
            product in human prostate cancer
  JOURNAL   Jpn J Cancer Res 93 (6), 605-609 (2002)
   PUBMED   12079507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_039081722.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.267206.1,
                                           SRR26360186.173844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  56744550-56744703
            155-301             JAXUCZ010000008.1  57010855-57011001
            302-454             JAXUCZ010000008.1  57012558-57012710
            455-592             JAXUCZ010000008.1  57020118-57020255
            593-751             JAXUCZ010000008.1  57022062-57022220
            752-851             JAXUCZ010000008.1  57032895-57032994
            852-1024            JAXUCZ010000008.1  57036502-57036674
            1025-1114           JAXUCZ010000008.1  57041336-57041425
            1115-1246           JAXUCZ010000008.1  57070067-57070198
            1247-4325           JAXUCZ010000008.1  57072186-57075264
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..4325
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1365
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; nectin-like protein 2; spermatogenic
                     immunoglobulin superfamily; immunoglobulin superfamily,
                     member 4A; synaptic cell adhesion molecule; tumor
                     suppressor in lung cancer 1 homolog"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform 6 precursor"
                     /protein_id="NP_001423454.1"
                     /db_xref="GeneID:363058"
                     /db_xref="RGD:1310999"
                     /translation="MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVY
                     DPPTTIPPPTTTTTTTTTTTTTTTILTIITDSRAGEEGAIGAVDHAVIGGVVAVVVFA
                     MLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI"
     sig_peptide     22..162
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule 2; member of the V-set of Ig
                     superfamily (IgSF) domains; Region: IgV_1_Necl-2; cd05881"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..225
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    169..177
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    178..198
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    202..228
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    226..243
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    order(244..246,253..255,268..273,277..279,295..297,
                     301..303,409..411)
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..267
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    244..264
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    268..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    274..288
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    292..303
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    304..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    316..339
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    346..366
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    385..411
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    412..423
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    421..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    427..450
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409465"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..747
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     nectin-like molecule 2 (Necl-2); member of the I-set of Ig
                     superfamily domains; Region: IgI_2_Necl-2; cd05883"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    451..462
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    469..483
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    508..540
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    547..576
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    577..588
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    592..615
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    622..654
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    676..702
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    721..744
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409466"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    784..1020
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    817..831
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..873
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    958..975
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1219..1275
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     misc_feature    1219..1275
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1114
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1246
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..4325
                     /gene="Cadm1"
                     /gene_synonym="Igsf4; Igsf4a; Necl-2; sgigsf; SynCAM;
                     TSLC-1; TSLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt cctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctcctct cggccgcggc actgatcccc acaggtgatg ggcagaatct gtttactaag
      181 gacgtgacgg tgattgaagg agaagttgca accatcagct gtcaagtcaa taagagtgat
      241 gactccgtga ttcagctact gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacaaatg tctcaatttc ggatgaaggg aggtacttct gccagctcta cacggaccct
      421 ccgcaggaga gttataccac catcacagtc ctggtccctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgcac ggccatggcc
      541 agcaagccgg ctacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggaag agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggatg atggagtccc agtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcggtatct agaagtgcag tataaaccgc aagtgcagat ccagatgact
      781 tatcctctgc aaggcctaac ccgggaaggg gatgcattcg agttaacgtg tgaagccacc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgacgaaat gcctcaacat
      901 gccgttctgt ctgggccgaa tctgttcatc aataacctaa acaaaacaga caatggtact
      961 taccgctgtg aggcttccaa cacagtgggg aaagctcatt cggactatat gctgtatgta
     1021 tacgatcccc ccacaactat ccctcctccc acaacaacca ccaccaccac taccaccacc
     1081 accaccacca ccaccatcct taccatcatc acagattctc gagcaggtga agagggcgcc
     1141 attggggcag tggaccacgc ggtgattggc ggcgtcgtag ccgtggtggt gtttgccatg
     1201 ctatgtttgc tcatcattct gggccgctat tttgccagac ataaaggtac atacttcact
     1261 catgaagcca aaggagccga tgacgcagca gacgcagaca cagctataat caatgcagaa
     1321 ggaggacaga acaactccga agaaaagaaa gagtacttca tctagatcag cctttttgtt
     1381 ccaatgaggt gtccaacggg cctgcttaga tgataaagag acagtgatac tggaactttg
     1441 gagaagctcg tgtggttttt tttttatgag tgggtggaaa gatgcgagac tgggaaggct
     1501 tgggatttgc aatgtaaaaa caaagacaaa aaatgttctt tgaaagtacg ctctgctgtt
     1561 tgacacctct ttttaatctg gttttaattt ggtttgggtt ttggtgtttt cgtttctatt
     1621 tcctcctacc aagtcaaact tgggtacttg gatttggttt cggtagattg cagaaaattc
     1681 tgtgccttgt ttttcattcg tttgttgtgt ttctttcccc ttgccctttt tgtgcattta
     1741 tttttcccaa aatcaaattt gtttttcccc ccctcccaaa cctcccattt tttggaattg
     1801 acctgctggg attcctaaga ttcccccccc caccccattt ctgatttctt tgtttgtgtt
     1861 gacggtgact gctttctgtt ccaaattcag tttcataaaa ggaaaaccag cacagtttag
     1921 atttcatagt tcagaattta gtgtctccat gatgcatcct tctctgttgt cgtaaagatt
     1981 tgggtgaact aaaaaaaaaa aagaaaaaaa gaaaaaaaaa agaaaacaat gaaaactctt
     2041 tgctgctgcc catgtcttaa atacttagag cagcgaagac tagaaacgta gactgtgacc
     2101 cagaagctgt cgtctgctgt ggatcttcat tactgtacag ggttatctgc aagtgaggtg
     2161 tgtcgcaatg agattgaatt tgtcgttaat tctttatctg taggcggctc agtatagatt
     2221 accccacgct gtgcagaacg gggggggggg ggttgttttt tttgtttttt tttttttttt
     2281 ttttggagtg gaaaggtctc ctccttcctc gttgccctaa acagatccga caggtgaggt
     2341 ctgtccgttt tatgtaagtg gacaaatttg agatgccaca ggaggggagg cagggagggg
     2401 gaacgacagt tctgctctgg ttatttctac tctggacaat ttcatccacc tttcccaatt
     2461 ggccttactg ctcgctgacg tgcaggagag agcaagtcca tgtgttgtgt gagtgactga
     2521 aggggacaga atttgtttag gtttttttcc ccacttttgt ttttgctttg ggtttttttc
     2581 ccctttgtgc ttattaagga aggcagtggg atgtgtcctg tatgtactgt atattacaga
     2641 caccgtcctg ctgggatttc cacctccagt ccctggctct gctctcattc cttcagattt
     2701 ggcttgacaa aggcaggagg tacaaaagaa gggccggcat tgttctcgaa aggtcagagc
     2761 caaggtggag aagcagcatg tagagatttt cagttactta atcaaaactc aaaatgtgag
     2821 tgtttctatc tttcctgcac tagccctggc ctctttcctc agccttaaga accatctgcc
     2881 aagaactcct catctcgcat gatggcagcc atagtgcata gcaactaaaa taagtttccg
     2941 tgaacatatc ttacaccgga gcctggggga aggtagagga gtggaggaac catttgcatt
     3001 ctctgaagct aggtaggggt ttgcagaagt gctgaggaca tctagaagta gttctgaagg
     3061 acaaagccta aactattacc acatgtgttg gtaagctcca gactccaaaa ctgtccctct
     3121 gggaagacgg caccagaaaa gatagagcta tctatatata aatatataaa tatatattat
     3181 ataacatttt cagtcagtac ttttggattt tgcaaggtgc atttttactc ttgttacatt
     3241 atgtggaaaa cttatgctga tttatttaag gggaaaaaag tgtcgactct gttatttgaa
     3301 aggatatttc tttttcttgt cttcatttta acttctgata gaaccactgc aatatgaggg
     3361 ccttttggga acggactggt gtgtaaaaga aaattcatca tcgagcagtg ttttgttaac
     3421 ccctctcctg cccctaggca cttaaccaag aaaaaagcca caaggaacat ccctttttca
     3481 agaattttat aatgtgcatc tattccgagc ccttagcacc catcctgacc atagtgtgac
     3541 catatcaaag ggtgacaacc agttagcatg tcgttgaaag ggtttttcag ctgttctttt
     3601 tagaaaaaaa atataaaaaa tattaaaaaa aactaaaaat aagcaaacac aaaaaaactc
     3661 ccattgttca cagaattggc atctcatttt cgggacagcc catctttctg ttttgacaag
     3721 tgtacagtag tgcggtgttc tgatgtaact ttatggctta agatgttgac atgtctcagg
     3781 ttcctgtgtt tcgattggtg tttttccgtc tcaggtagat tgcaaagtgt aggccccaca
     3841 cattggaaaa ataataataa taataataaa taataataat aataattaaa caaagcaaaa
     3901 acaggaaatt acggatttta gttgtatatt ggtttatgta tttttcttaa gtatacagtg
     3961 cactgtttga aatgtattgt tgagtattac tttgtacagg ttgatcactt tttttagagt
     4021 gaagaaagaa caaacttggt ttttttgtgt ttttttaaag gagtataaaa taatgaagga
     4081 tgtataattg atgccaaata agcttgttct ttagtcacga tgacgtcttg ttttccctct
     4141 aggccagttc tgtttctaag gtgtacaagg accatgttac agtgtaagaa actccacatc
     4201 cgtgtgttcc attcgcattt tgtatcggtt catgtatacc atttttacaa aaagaaaaaa
     4261 gaaaaaaaaa agaagtacta taaaatatct gtcttcttaa taaaaaagat taatgttaca
     4321 agtga
//
LOCUS       NM_001436490            4999 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus immunoglobulin superfamily, member 9B (Igsf9b),
            transcript variant 1, mRNA.
ACCESSION   NM_001436490 XM_235959
VERSION     NM_001436490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Woo,J., Kwon,S.K., Nam,J., Choi,S., Takahashi,H., Krueger,D.,
            Park,J., Lee,Y., Bae,J.Y., Lee,D., Ko,J., Kim,H., Kim,M.H.,
            Bae,Y.C., Chang,S., Craig,A.M. and Kim,E.
  TITLE     The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM
            to promote inhibitory synapse development
  JOURNAL   J Cell Biol 201 (6), 929-944 (2013)
   PUBMED   23751499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_235959.11.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000008.1  33971825-33972116
            293-490             JAXUCZ010000008.1  33982295-33982492
            491-637             JAXUCZ010000008.1  33984368-33984514
            638-789             JAXUCZ010000008.1  33989337-33989488
            790-907             JAXUCZ010000008.1  33989774-33989891
            908-1049            JAXUCZ010000008.1  33991152-33991293
            1050-1195           JAXUCZ010000008.1  33991471-33991616
            1196-1338           JAXUCZ010000008.1  33993926-33994068
            1339-1479           JAXUCZ010000008.1  33994369-33994509
            1480-1596           JAXUCZ010000008.1  33994600-33994716
            1597-1747           JAXUCZ010000008.1  33994965-33995115
            1748-1859           JAXUCZ010000008.1  33996000-33996111
            1860-2035           JAXUCZ010000008.1  33998544-33998719
            2036-2262           JAXUCZ010000008.1  34000145-34000371
            2263-2347           JAXUCZ010000008.1  34001143-34001227
            2348-2509           JAXUCZ010000008.1  34003269-34003430
            2510-2555           JAXUCZ010000008.1  34004163-34004208
            2556-4211           JAXUCZ010000008.1  34004745-34006400
            4212-4333           JAXUCZ010000008.1  34013702-34013823
            4334-4999           JAXUCZ010000008.1  34017028-34017693
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..4999
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="immunoglobulin superfamily, member 9B"
                     /db_xref="GeneID:315510"
                     /db_xref="RGD:1564717"
     exon            1..292
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    199..201
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="upstream in-frame stop codon"
     CDS             229..4542
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein turtle homolog B"
                     /codon_start=1
                     /product="protein turtle homolog B isoform 1 precursor"
                     /protein_id="NP_001423419.1"
                     /db_xref="GeneID:315510"
                     /db_xref="RGD:1564717"
                     /translation="MIWYVATLIASVISTRGLVAQVAHGLREEPEFVTARAGEGVVLR
                     CDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQ
                     VRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMT
                     CTAFGNPKPIVTWLKEGTLLSASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAV
                     HTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDL
                     KLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI
                     YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEAL
                     GTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFP
                     VITWRKVGKPSRSKHNALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT
                     SPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLSVPLGPSW
                     LLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVTPPRCLTAN
                     RTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEMLDDAIPGTDGEFFAKDLSQDTWY
                     EFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAAAILF
                     STLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSD
                     DQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISRGPDG
                     RFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKPQLTP
                     MSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRPFQHGQYYGYLSS
                     SSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTLPLTQT
                     PTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKPCLPRGLPPAPLQVP
                     AAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQGMGIPV
                     LPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPL
                     TQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGSPSQS
                     SRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDNLDVFGQTPSPRRMGEEPLRPEP
                     PTTLPTSGILPPAPGNAAVPERLEALRYQRIKKPKKSSKGSSKSKKRSDGSASQDQQL
                     PNSQVLWPDEAVCLRKKKRHSRPDPFARLSDLCHRQLPEDQTAILNSVDHDDPGHATL
                     L"
     sig_peptide     229..288
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1)"
     mat_peptide     289..4212
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /product="Protein turtle homolog B. /id=PRO_5003052708"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1)"
     misc_feature    349..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:409353"
     misc_feature    349..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:409353"
     misc_feature    349..363
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    349..363
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    403..417
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    403..417
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    514..528
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    514..528
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    556..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    556..573
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    643..903
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    643..903
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    697..711
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    697..711
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    736..750
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    736..750
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    841..858
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    841..858
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    880..891
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    880..891
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    910..1149
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    910..1149
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    949..951
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    1000..1002
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    1234..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1234..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1252..1266
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1252..1266
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1291..1308
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1291..1308
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1366..1380
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1366..1380
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1408..1425
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1408..1425
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1447..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1447..1458
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1513..1743
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1513..1743
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1540..1554
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1540..1554
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409544"
     misc_feature    1579..1593
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1579..1593
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409544"
     misc_feature    1639..1653
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1639..1653
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409544"
     misc_feature    1681..1698
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    1681..1698
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409544"
     misc_feature    <1696..>2421
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    <1696..>2421
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1720..1731
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1720..1731
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409544"
     misc_feature    1756..2031
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1756..2031
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1756..1758,1948..1950,1993..1995)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1756..1758,1948..1950,1993..1995)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1996..2001,2005..2010)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1996..2001,2005..2010)
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2098..2100
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); glycosylation site"
     misc_feature    2395..2457
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     transmembrane region"
     misc_feature    2500..2679
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2551..2553
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    2575..2577
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    2608..2610
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    <2908..3954
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2908..3954
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2968..3348
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3547..4212
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZB51.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3634..3636
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:E9PZ19; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); methylation site"
     misc_feature    3847..3849
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     misc_feature    3871..3873
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:E9PZ19; propagated from
                     UniProtKB/Swiss-Prot (D3ZB51.1); phosphorylation site"
     exon            293..490
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            491..637
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            638..789
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            790..907
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1049
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1195
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1338
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1479
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1596
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1747
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1859
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2035
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2262
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2347
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2509
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2555
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..4211
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4333
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4999
                     /gene="Igsf9b"
                     /gene_synonym="RGD1564717"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctctgcc tccgttggca gtgcaggtgc cgctgcgccg gggcccggga ggctgcgcgc
       61 gccgagacga gaggagccag ggagggatgg agagcgggcc gcccgggcta cagaagcacc
      121 ggcaaggggc gtaggcgggc gagaagcggg cattgaggca ccagaagtgt gcagacgcag
      181 gagcactttg cgataggatg aggctcttgg ctggcgcgcg gtagtactat gatttggtat
      241 gtggccactt tgatagcaag tgtgatcagc acccgaggtc ttgtggctca agttgcccac
      301 ggcctgcgag aggaacctga gtttgtgacc gctcgtgccg gcgaaggtgt ggttctgcga
      361 tgcgacgtca tccacccagt gacaggacag cccccaccct atgtcgtaga gtggttcaag
      421 tttggggtcc ccatccctat cttcatcaag tttggctact atcccccgca tgtggaccct
      481 gagtatgcag gccgggccag tcttcatgat aaagcatctc tgcggctgga gcaggtgcgc
      541 tctgaggacc agggttggta cgagtgcaaa gtgctcatgc tggatcagca gtatgacaca
      601 ttccacaacg gcagctgggt ccatctcacc attaacgccc ctcccacctt tacagaaaca
      661 cccccccagt acatcgaggc caaggaaggt gggagtatta ccatgacttg cacggctttt
      721 gggaacccta aacccatcgt cacctggctc aaggaaggga ccctcctcag tgctagtgga
      781 aagtatcagg tgagtgacgg tagcctaacg gtgacgtcag tcagtcggga ggacagaggc
      841 gcctatacct gtcgagcata tagcatccag ggtgaggctg tgcacacaac ccatctgctt
      901 gttcaagggc ctcccttcat tgtttcccct cctgagaaca tcaccgtcaa catctcccag
      961 gatgctctgc ttacctgcag ggcagaggcg tatcccggca acctcaccta cacctggtac
     1021 tggcaggatg agaacgtcta cttccagaat gacctgaagc taagggtgcg gatcctgatt
     1081 gatgggacac tgatcatctt ccgagtgaag ccagaggatg ctgggaagta tacctgtgtc
     1141 cctagcaaca gcctggggcg ttccccctct gcctcagcat acctgactgt gcagtaccca
     1201 gcccgtgtcc tcaacatgcc ccctgtaatt tatgtgcccg tgggaatcca tggctatatc
     1261 cgctgtcctg tggatgcaga gccgcctgct actgtggtga agtggaataa ggatggccgg
     1321 cccctgcagg tagagaagaa cttgggttgg accttgatgg aggatggctc tattcgaatt
     1381 gaggaggcca cagaggaggc tcttggcact tacacctgtg tgccttacaa cactttgggg
     1441 accatgggcc agtctgcccc tgcccggctc gtcctgaagg accccccgta tttcacggtg
     1501 ctacccggct gggagtacag gcaggaggct ggccgggagc tgctcatccc ctgtgcagct
     1561 gcaggggacc ccttccctgt catcacctgg aggaaggtag ggaagcccag cagaagcaag
     1621 cacaatgcac tgcccagcgg gagtctgcag tttcgtgccc tgagtaagga ggaccacggg
     1681 gagtgggaat gtgttgccac caacgtggtc acaagcatca ctgccagcac ccacctcact
     1741 gtcatcggca ccagtcccca tgccccaggc agtgtccggg tccatgtctc catgacaact
     1801 gccaacgtgt cctgggagcc aggctatgat ggaggctatg agcagacatt ctcagtttgg
     1861 atgaagcggg ctcagtttgg gccccacgac tggctgtcct tgtcagtgcc actgggcccc
     1921 agctggctgc tggtagacag cctggagcct gagactgcat accagttcag tgtcctggcc
     1981 cagaacaggc tggggaccag cgccttcagt gaggtggtca ctgtgaacac tttagcattc
     2041 cctgttacaa ctccagaacc cctggtgctg gtgaccccac caaggtgcct cacagccaac
     2101 cggacccagc agggtgtgct cctgtcctgg ctccctcctg ccaaccacag cttccccatc
     2161 gaccgctaca tcatggagtt ccgagttggg gagcgctggg agatgctaga tgatgccata
     2221 ccaggcaccg atggagaatt ttttgccaag gatctgtcac aggatacctg gtatgagttc
     2281 cgggttttgg ctgtcatgca ggatctgatc agcgagccca gcaacatcgc cggtgtctcc
     2341 agcacagaca tcttcccgca gccggacctg actgatgatg ggctggcccg gccagtgttg
     2401 gctgggatag tggccaccat ctgcttcctg gcggctgcca tcctcttcag cactctggct
     2461 gcctgctttg tcaacaagca gcgcaaacgc aaactcaagc ggaagaaaga tcctccgctc
     2521 tccatcactc actgtaggaa gagtcttgag tctcccttgt cctctggcaa ggtgagtcct
     2581 gagagtatcc gcacactccg agccccgtct gaatcctctg acgaccaggg ccagccagca
     2641 gccaagagga tgctgagccc tacaagggag aaagagctgt ccctgtacaa aaaaaccaag
     2701 agggctatca gcagcaggaa gtatagcgtg gccaaggctg aggccgaagc agaggccacc
     2761 acacccattg aactgatcag tagaggcccg gatggccgct tcgtcatggg cccgtcggag
     2821 atggagccct ctgtgaaggg ccggcgaatc gaaggcttcc ccttcgctga ggagacggac
     2881 atgtaccctg agttccggca gtcagatgag gagaatgaag acccactggt acccacgtct
     2941 gtggctgctc tgaagcctca actgacccct atgtcttcca gccaggactc ttacctgcca
     3001 ccaccagcat acagccctcg gttccagcct cgagggctcg agggccccag tggactggga
     3061 ggacgactcc aggctactgg ccaagcgagg cctcctgccc ctcggccctt ccagcatggc
     3121 cagtattatg ggtacctcag cagcagcagc cctggggagg tggagcctcc acccttctat
     3181 atgccagaag tgggcagccc cttgagctca gtcatgtcgt ccccacccct gcacaccgag
     3241 gggccttttg gccaccctac catccctgag gaaaacggag agaatgcttc taacagcact
     3301 ttgcccttga ctcagacacc tacaggaggg cgctcccctg agccctgggg ccggccagaa
     3361 tttccctttg ggggactgga gaccccagct atgatgttcc cccaccagct gcacccctgt
     3421 gatgtggccg agagtttgca gcccaagccc tgtctgcccc gaggactgcc cccagccccg
     3481 ctccaggtgc ctgcagccta tccaggcatg ctatctctgg aggcaccaaa gggctgggta
     3541 ggcaagtcac ctggcagggg tcccatcccg gcgccccctg ccaccaagtg gcaggaaaga
     3601 cctatgcaac ctctggtcag ccaagggcag ctaagacata ccagccaagg tatggggata
     3661 ccggtgttgc cttacccgga gccagccgag cccggggggc acggtggccc cagcacattt
     3721 ggcctggaca ctcggtggta tgagccccag ccccggcccc ggcccagccc ccggcaggcc
     3781 cggcgtgccg agcccagttt acatcaagtg gtgctacagc cctcccggct ctcacctctg
     3841 acccaaagcc cccttagttc ccgcactggc tcccctgagc tcgctgctcg tgcccgacct
     3901 cgaccaggcc tcctgcagca ggcagagatg tcagagatca ccctgcagcc gccagccgcg
     3961 gtcagcttct ctcgcaagtc aacaccatca tccacgggat ctccttcaca gagcagccgc
     4021 agtgggagcc ccagctacag gcccacaatg ggcttcacta ctctggccac aggctaccct
     4081 tctccaccac ctggccctgc ccctccggcg ccaggggaca acttggatgt gtttggacag
     4141 acgccttccc ctcggaggat gggggaggag ccactccggc cagagccccc aacaacctta
     4201 cctacttcag gaatacttcc acctgcaccc gggaacgctg ctgtgcctga gaggctggag
     4261 gctctgagat accaacggat aaagaagccc aaaaagtcat ccaagggctc ttcgaagtca
     4321 aagaaacgat ccgacggttc tgcctcccag gatcagcagc ttcccaactc tcaggttctg
     4381 tggcccgacg aagctgtctg cctcagaaag aagaagagac actctcgtcc tgatcccttt
     4441 gcccggcttt cagacttgtg ccaccgtcag cttccagaag accagacggc catcctcaac
     4501 agtgtggatc atgatgaccc aggccacgct actctgctat gacttgacac cattctaaat
     4561 gtccccaggg tggggtgcta ggctaaaggg ggcagagagg gaccattgta cagggccttg
     4621 tcctcctctg cccatcatgg gatggctcag gcccctgacc tgtgtgtatt ccctcatgcc
     4681 agtggggaat acacccacta tctagccagc tagccttgcc catgggacag aggactaggg
     4741 gaagagcttt taactgtggg tcagagttgg gagtatgtgg ggatagaaga catctgtctc
     4801 tatgccacct ctcccacttt actagattgg ttcttctcac ctcttccaac gtcttaggaa
     4861 gtgaggaaac ggaaagcaat ggcttttagt aatgcatttg tttcactttt ccaagtcctg
     4921 ggagggggtt agagttatat ccgaccctcc taactccaca tatatataga tatagataca
     4981 aatgcacttg tgtgtcgtt
//
LOCUS       NM_001436526             515 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus ripply transcriptional repressor 2 (Ripply2),
            transcript variant 2, mRNA.
ACCESSION   NM_001436526 XM_343444
VERSION     NM_001436526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Takahashi,J., Ohbayashi,A., Oginuma,M., Saito,D., Mochizuki,A.,
            Saga,Y. and Takada,S.
  TITLE     Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism
            underlying the rostro-caudal patterning within a somite
  JOURNAL   Dev Biol 342 (2), 134-145 (2010)
   PUBMED   20346937
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Chan,T., Kondow,A., Hosoya,A., Hitachi,K., Yukita,A.,
            Okabayashi,K., Nakamura,H., Ozawa,H., Kiyonari,H., Michiue,T.,
            Ito,Y. and Asashima,M.
  TITLE     Ripply2 is essential for precise somite formation during mouse
            early development
  JOURNAL   FEBS Lett 581 (14), 2691-2696 (2007)
   PUBMED   17531978
REFERENCE   3  (bases 1 to 515)
  AUTHORS   Kawamura,A., Koshida,S., Hijikata,H., Ohbayashi,A., Kondoh,H. and
            Takada,S.
  TITLE     Groucho-associated transcriptional repressor ripply1 is required
            for proper transition from the presomitic mesoderm to somites
  JOURNAL   Dev Cell 9 (6), 735-744 (2005)
   PUBMED   16326386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_343444.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.184625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000008.1  96854729-96854822
            95-173              JAXUCZ010000008.1  96855060-96855138
            174-238             JAXUCZ010000008.1  96855469-96855533
            239-515             JAXUCZ010000008.1  96858684-96858960
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..515
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="ripply transcriptional repressor 2"
                     /db_xref="GeneID:363111"
                     /db_xref="RGD:1308746"
     exon            1..94
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..395
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ripply2 homolog"
                     /codon_start=1
                     /product="protein ripply2 isoform 2"
                     /protein_id="NP_001423455.1"
                     /db_xref="GeneID:363111"
                     /db_xref="RGD:1308746"
                     /translation="MDTTESAESAHSPARSPSRSRCPPPAQPGSEGFWRPWVRTPGEK
                     EELAEPRAAEVLPSGPGMIEASRKLLQYQHPVRLFWPKSKCYDYLYQEAETLLKNFPI
                     QATISFYEDSDSEDDVEGLACENQSN"
     misc_feature    105..359
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="Transcription Regulator; Region: Ripply; pfam14998"
                     /db_xref="CDD:464433"
     misc_feature    105..359
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /note="Transcription Regulator; Region: Ripply; pfam14998"
                     /db_xref="CDD:464433"
     exon            95..173
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
     exon            174..238
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
     exon            239..515
                     /gene="Ripply2"
                     /gene_synonym="RGD1308746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccggccat ggataccacg gagagcgccg agagcgcgca cagcccagca cgttcgccct
       61 cgcgcagccg ctgcccgccg cccgcgcagc ccgggtccga gggcttctgg agaccgtggg
      121 ttagaactcc tggcgagaaa gaggagctgg cggaacctcg tgctgcagag gtgttgccca
      181 gcggcccggg aatgattgaa gcttccagga agcttttgca ataccaacac cctgtcagac
      241 tattctggcc caagtccaag tgttacgact acttatacca agaagcagaa actcttctga
      301 aaaattttcc aattcaagct acaatttcgt tttatgaaga ctctgatagt gaagatgacg
      361 tagaggggct ggcctgtgaa aaccaatcta attagttcct tctgttgaca attgagctgg
      421 gtagaatctg aattttgtac ataaatgtac cataactttt taaaactaat ttatttgtat
      481 atacgttatt aataaaatat tttgtaataa ctata
//
LOCUS       NM_001436520            8934 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 44
            (Zbtb44), transcript variant 2, mRNA.
ACCESSION   NM_001436520 XM_006242768
VERSION     NM_001436520.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8934)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 8934)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_006242768.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32891.1,
                                           SRR26643285.30517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000008.1  37724537-37724791
            256-1329            JAXUCZ010000008.1  37747440-37748513
            1330-1414           JAXUCZ010000008.1  37768061-37768145
            1415-1578           JAXUCZ010000008.1  37770183-37770346
            1579-1879           JAXUCZ010000008.1  37772485-37772785
            1880-8934           JAXUCZ010000008.1  37775166-37782220
FEATURES             Location/Qualifiers
     source          1..8934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..8934
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="zinc finger and BTB domain containing 44"
                     /db_xref="GeneID:363035"
                     /db_xref="RGD:1308984"
     exon            1..255
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            256..1329
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    264..266
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="upstream in-frame stop codon"
     CDS             312..2162
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger and BTB domain-containing protein 44; BTB/POZ
                     domain-containing protein 15; BTB (POZ) domain containing
                     15"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 44
                     isoform 2"
                     /protein_id="NP_001423449.1"
                     /db_xref="GeneID:363035"
                     /db_xref="RGD:1308984"
                     /translation="MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDRIFRA
                     HKVVLAACSDFFRTKLVGQTEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENII
                     DVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENSSNCNFTSRDGSI
                     SPVSSECSAVERTIPVCRESRRKRKSYIVMSPESPVKCSTQTNSPQVLNSSASYAENR
                     NQPVDSSLAFPWTFPFGIDRRIQPEKAKQAENTRTLELPGPSEAGRRMADYVTCESTK
                     TTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEPVQEDLLISP
                     QSSSIGSVDEGVTEGLPTLQSTSSTNAHADEDDRLENVQYPYQLYIAPSTSSTERPSP
                     NGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDCCGKKFTRAYSLKMHRLKHE
                     GKRCFRCQICSATFTSFGEYKHHMRVSRHIIRKPRIYECKTCGAMFTNSGNLIVHLRS
                     LNHEASELANYFQSSDFLVPDYLSQEQEEALVQYDLGEHTSESSSSVQMPVISQVSST
                     HNCESTFPLGSLGGLAEKEEDLQEQPKTSAHDDAPRDDPPKAELSSITIE"
     misc_feature    354..701
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 44 (ZBTB44); Region:
                     BTB_POZ_ZBTB44; cd18228"
                     /db_xref="CDD:349537"
     misc_feature    354..701
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 44 (ZBTB44); Region:
                     BTB_POZ_ZBTB44; cd18228"
                     /db_xref="CDD:349537"
     misc_feature    714..716
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCP5; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    786..788
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    792..794
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    804..806
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    882..884
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    891..893
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    906..908
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    909..911
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8R0A2; propagated from
                     UniProtKB/Swiss-Prot (Q3SWU4.1); phosphorylation site"
     misc_feature    918..>1277
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="outer membrane protein PgaA; Provisional; Region:
                     pgaA; PRK10049"
                     /db_xref="CDD:236644"
     misc_feature    918..>1277
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="outer membrane protein PgaA; Provisional; Region:
                     pgaA; PRK10049"
                     /db_xref="CDD:236644"
     misc_feature    1032..1106
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1194..1283
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1317..1415
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SWU4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1506..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1512..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1512..1574
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1512..1514,1521..1523,1560..1562,1572..1574)
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1512..1514,1521..1523,1560..1562,1572..1574)
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1527..1529,1533..1535,1539..1541,1545..1550,
                     1557..1562,1569..1571,1611..1613,1617..1619,1629..1634,
                     1641..1646,1653..1655,1695..1697,1701..1703,1707..1709,
                     1713..1718,1725..1730,1737..1739)
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1527..1529,1533..1535,1539..1541,1545..1550,
                     1557..1562,1569..1571,1611..1613,1617..1619,1629..1634,
                     1641..1646,1653..1655,1695..1697,1701..1703,1707..1709,
                     1713..1718,1725..1730,1737..1739)
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1548..1625
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1548..1625
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1596..1658
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1596..1658
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1680..1739
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1680..1739
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1776..1844
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275371"
     misc_feature    1776..1844
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275371"
     exon            1330..1414
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1578
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1879
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..8934
                     /gene="Zbtb44"
                     /gene_synonym="Btbd15; RGD1308984"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctcgcac ctcgcgtgca cgcgggtgag cggcgccgcc atgcgcgccc agtcccaggc
       61 tgcacactgg cctaggcgcg gcggcccgag atagggtccc ctgagcctcc cgggggagga
      121 gaggagccag ccgcgcgctc cgccccctcc ccccgggttg ccgccgctac cgccaccgcc
      181 acctcgccgc cccagcctgg cggggaagag gaggagcagt tgcaggcctc cgggcccccg
      241 caccgccgcc cgcagggtaa ttctgattca ttgcatcctt gaagagcatc aatagaagag
      301 ggggaaaaaa gatgggtgtg aaaacattta ctcacagctc ctcttcccac agccaggaaa
      361 tgctgggaaa actaaatatg ctacgaaatg acggacattt ttgtgatatc actattcgtg
      421 tccaggacag aatcttccgg gctcacaagg tggtactagc agcttgcagt gatttctttc
      481 gaaccaaact tgtgggccaa acagaggatg agaacaaaaa tgtgttggat ctgcatcatg
      541 ttacagtgac tggctttata cctctgctgg aatacgctta cacagccact ctgtccatta
      601 acacggaaaa tattattgat gttctagcag cagccagcta tatgcaaatg tttagtgttg
      661 ctagtacgtg ctcagagttc atgaaatcaa gtattttgtg gaatacacct aatagccaac
      721 cagaaaaggg tctagatgct ggacaagaaa atagttccaa ctgcaatttt acttctcgag
      781 atggaagcat ttctccagtg tcttccgagt gcagtgctgt ggaaaggacc attcctgtct
      841 gccgagagtc ccggagaaaa cgcaaaagct acattgttat gtctcctgag agccctgtaa
      901 aatgtagcac acaaacaaat tccccccagg tactgaattc ttcagcttcc tatgcagaaa
      961 atagaaatca gccagttgat tcttctttag cgtttccatg gactttccct tttggaattg
     1021 ataggaggat tcagcctgag aaagcaaagc aggcagaaaa tacccggact ttagagttgc
     1081 ctggcccgtc cgaggcaggt agaaggatgg ctgactatgt gacttgtgag agcacaaaaa
     1141 ctaccttgcc tctaggtaca gaagaagacg tccgggtcaa agtagaaaga ttaagtgatg
     1201 aggaggttca tgaggaagtg tcccagcccg ttagtgcatc tcagagctca ctgagtgatc
     1261 agcagacggt gcctggaagt gaaccagttc aagaggacct tctgattagt ccacagtctt
     1321 cctctatagg ctcagtggat gaaggagtca ctgaaggatt gcctacactt cagagcactt
     1381 ccagcaccaa tgctcatgca gatgaggatg acagattgga aaatgttcag tatccctatc
     1441 aactgtacat tgctccttct accagcagta cagaacgacc aagtccaaat ggtccagaca
     1501 gaccttttca atgtccaacc tgtggggttc gcttcacccg tattcagaat ctaaaacagc
     1561 acatgcttat ccactcagga attaaaccat ttcagtgtga ctgctgtgga aaaaagttta
     1621 ccagggctta ctcgctaaag atgcatcgcc taaagcacga aggtaaacgc tgtttccggt
     1681 gccagatatg tagtgccact ttcacttcct tcggggagta taaacaccat atgagggttt
     1741 cccggcacat tatccgcaag cctcggattt acgagtgcaa aacatgtggc gccatgttca
     1801 ccaactctgg aaatttaatc gtgcacctga ggagtctgaa ccatgaagca tcagagctag
     1861 caaactactt ccagagcagt gatttcttag taccggacta cttaagccag gagcaagaag
     1921 aggcccttgt tcagtatgat cttggagagc acacttctga aagcagctct tctgttcaaa
     1981 tgcctgtgat ttcacaggtc tcctcaaccc acaactgtga aagcactttt cccctggggt
     2041 ctcttggtgg gcttgcagaa aaggaggagg acctgcaaga gcagccaaag accagtgctc
     2101 acgatgatgc tccccgagat gaccccccca aggcagagct gtcttctata actattgagt
     2161 gattctgtga ttggcctggg ttttggggtt tttttgtttt gttttgtttg tttgtttgtt
     2221 tgtttgtttt ggaaagtgcc tgtgcttggt ctcatatgtt taaatttaat ttaatttttt
     2281 aaaaaggggt tccctttgta agctctgaaa ctagagggtt ctttgttttg ttttgttttt
     2341 tcatagcttt agtatgtata caataaggta acattgaaac agaacataaa ctttaagagt
     2401 aaggaaaagc agctgactta gaacatggca gttcttccat tgttaaaagt gggcagcagc
     2461 agatacaaaa gaagtcgggt tgttgttgac ctttctgaga taagagggct aatgagaagt
     2521 tactaaagag tttgacaaag cctaaggaat gtttactcct ggacacaggg tgttagaaac
     2581 cctgtagttt tggaagaatt tacggtattt tttttttcag atgacggtaa ataacttctg
     2641 aaatccagta tattcttttt ttttttttta agccattttg gattttcatg gtgaaaaatt
     2701 agtatcaggc aggtattttc tgtacctttg tagtactcct ccaaaggcta ggtgtggttg
     2761 agaagagtca ggcgcgcgtg gaatggcagg gcgcagaacg aggtacgtat acccagcttt
     2821 gcaggaactc tcttcagact gtttttttta ctggccattg actgctgaca tctggttaac
     2881 taggacattg ctcagataag tgtcctcgtg tcccatcaac agcactttca cttgcatata
     2941 tactattgtg ctgccatata aaagaaaaat attgaagata ttctatattt tatatatagg
     3001 tttatgtatt gttgaggatg tcgatgctgt gctgttttgg acaaaataaa agaattctgt
     3061 tttgaggcta cattcttaac ccaattaaga ttgtttacaa gatcacattt gacaacaata
     3121 taatgttctt attccaaaat attttaaggt attgccaagt ttgttaaaag ccgctattac
     3181 atagttttca caggatgtga gcaataatgt gaaagataag aggtggtaaa atgatcatct
     3241 atgactcaaa acttagagga gcgattgtta agactaagat ctaaaaactt tgctactcag
     3301 atgataaaat ttatatgata ctctagattg ggatatactt ttttatctgc tgccattaaa
     3361 gcctctttga tctgaagtat tcatgaatca ataaataatg aacttatgtg taattttttt
     3421 ttttcccgga actagggacc gaacccaggc ccttgcactt gctaggcaag cgctctaccg
     3481 ctgagctaaa tccccagccc cgtaattttt tatatagaaa gtagccccag catttatcat
     3541 tgtggtagcc cctgatgggg ttagaagata aaaactacat atgttttttt gtttgacttt
     3601 ggatatttgt aacaggatca taggtagccc aggttggtcc agaactcatg atcctattgc
     3661 ctcagttccc ccacaatgct tgttaacatt acatatcata gacacatcac cacatccaga
     3721 tcaagctata gtcttagtca aacacatgat ctgactttta ccccagtgcc agaccttact
     3781 tacttacact ttatgtttta gtaatttgtc tctttaaaat ttattaattc tgcaatttaa
     3841 tttctatctc tgtccttttt tcttcttaat actgagagtt gaacccagga ctttatatat
     3901 tatgagcatg tgctctatca ctagatccaa ccccaacccg tatttctagt tttttacctg
     3961 actcatttgc tcccaagcat aagtgtgtga ccttcagaaa agtcaactaa aagagtcagt
     4021 aatttttatt ttattatcat atgatctttg aaaactgtgc ctactaatac ataaatccta
     4081 aaactcatta gaatcctatt ttagtaaggt aaatgttttt ggttctaaac tgggttttta
     4141 ttttgttaag agctagaaaa aggggaaagg aagaaagaaa taagagtaaa tcagagatga
     4201 attgatttga agaattcttt tgagattttt ggtgaaagtg tttcagtatg ccctctccta
     4261 ggaattctga attaggacag ccctgctagc ttccctggga aggacgtgcc tcactgtgga
     4321 ttttcattac tagtgacaaa tcttggagcc aaccttaatg agaaattcca atatactatg
     4381 aatgcacaaa tggttagatg cctactgccc aaatcttttt gataaagtta cccgaccagt
     4441 gttttttttt tttttttggt tctttttttc ggagctgggg accgaaccca gggccttgcg
     4501 cttcctaggt aagcgctcta ccactgagct aaatccccag cccccgacca gtgtttaata
     4561 taaaatgata caaaggcctt tttctgttcc aatatgactc tacatttttt gaggacattt
     4621 tgtttatggg tctattatag gaaatacaac tgcaagagat aattgtatat atagtaatac
     4681 ttaaagttta tttaaagttg atttaagagg ggaatgccta gatgtatact tttcaccaga
     4741 acatatggaa aacattgtga agagatgaaa gccagttaat gtgatcccat catagaaatc
     4801 accaggggaa ctaaacagag aagcagtctt gtttagaata aatatttaaa ggtagctatc
     4861 tttcgtaagg cctacgaggg taactttgtg atatttaaag ggcttacatt ttagaatgct
     4921 agataagtta ctttttaaaa atctaagcat tttatataag aaaagctctg ttttcaattt
     4981 ttttccaact accaaataga taggatgtgc tttagaggta aagtcttcac cgtgttggag
     5041 gcggtagccc ctcctgtcag tctttgcatt tccaaactcc agcttcagag ggtcacgtca
     5101 ggacgccact gactcagaaa cagaaagtta acaggacact ttaccttgtg catttaaatt
     5161 ttctaagaaa tggatattga taacgttatt atccaaaaat atgtgagctt ctcttaattg
     5221 gccattttaa acaatcctaa tttttatttt gagtctaatt tcaagtttaa ccacagttca
     5281 ttattactag gttttatttt gagtttttca ggggtggagt ttaatttttt tttttaagtt
     5341 cacaattttg ttaagacaga atgtactaaa atgtttaagt tgcttcattt cagtcttatg
     5401 tttgaacata ttaagtccca ataaatagga tccgtgttaa gatacattcc ctttgttatt
     5461 aaaaacaaac agaaaatact tgttaaaatg ttttactaaa tagagtggag gagtaagggc
     5521 ctctggttca ctgagtcatt ggttctccag ttgccttcta actacggagc caggctctcc
     5581 tgttttaaaa ctgatcccca ttcctttaga agctatgtta agtctttcac tccttgaaaa
     5641 aaggctctcc tttcatttgt ctaattaata gaaggcactt gcatggtgag tgtctgtttt
     5701 cagattaggc gttagtctgt tagcttttct aaggtacatg accatacagt gttatgcaga
     5761 ggggatcctc tagcaggatc tcagacactg ttttcttatg atggcaaatg agcagtcctc
     5821 aattctaact cgagagattt tggtttgtag acctaatgac caggcgaatt agaaacttcc
     5881 attgtactgc atcactcatc tgcccaaagg gccttcaaac tgaagtatac acctacatga
     5941 aggaatgatg tgagttctta actaggagtg ggggaaaaga actaggaaag ctcacataat
     6001 ggagcagaca gcccaaaggt aggggagaaa gataggtttt cactgtaaac gttgacatca
     6061 gacgcctttt tatatttcca tagttactaa gagaacatat agaaaccaga aggcagtgga
     6121 acaaaagtga gggagtagag agatgttatt gttgtagtaa atacagctat gaggaatatt
     6181 tataactaaa tacatgtttt aaataagatc aaaattaaga tttcttattt tgcttatact
     6241 agtatttatc cactcttgtt tttgacagaa tgtggtgacg tgggataatt tttacgtgaa
     6301 aaatcttcag caaaacaaat ttaccaaaat agcaatgggt cagctaaaca ctggagtggc
     6361 attaagccag tccgcaagcc ggttaagaag taggctgtaa tgtttcactc cggaatgcat
     6421 aacttgagat gtttgctgca acctagaaac atgaactgtg tagaacaggg aatgctgctg
     6481 ggcactacca ggagttactg aagtgatgag tgagatgctt tcccatatcg taattctggt
     6541 ttataataga agcgatagtt ccatggtttt ggaagtagtc actgtagatt ccagacagtc
     6601 cagttggagc cttggctttg gcagtgtctg aacatgttgc tttaactgct ccttcaactt
     6661 tagcagtgct ccctgagtga aacccaggcc ggttccagca gacaccgggc ttcctgtgga
     6721 cataacagtt tacaaaaact taggagttca gaccctgatt gagaaacatt aaaattaatg
     6781 tttttattaa aagtataaga gaaaattaag tttttttaag tgcctaattt ataaagttaa
     6841 attctttatt tctaagttat caagctttgc taagcctaaa aaccctgggc tcagttgtga
     6901 tgatttacta gtaaagtcac cagtaatcat ttgaggagct atagtgtcat gacttttact
     6961 aaattccttg ttttctcaaa tggcagactg actataccta gagcttgaaa agtcaccctg
     7021 tgagtgagtt cattaccaaa gcccgtcacc tgctgagtag tcagcgctgt ctgcacagga
     7081 gggagtagtg tggcttcaag atggcagcat tgtccgcagt ggtgttttcc agagagcctt
     7141 ttctgtgagt agtgtgtgcg tgccctctga gcttgtcctg ttaggtagcc gttctccggt
     7201 tgacagctga tatgaaggtc tttggcactg agaatgcagt tttgaaagtt gcactgcttt
     7261 tctgccccct agagtgagtg gcattggata tttagaagtg aggccataaa cttgttactt
     7321 tgtttataca aaatgatggc ttccgatgct tatgtatgga agtattgctt aaagaacagc
     7381 ctctgataag gtaaaatctg gttttgactc aagttctaat gatgtattta gtttattgat
     7441 actggtgtct cctgttgcat cagctagata ttgcctgcct ctttgttaag gcaccctgtg
     7501 gcaccttacg ttcaacttga aggatggtat gtggcctctt tgtgcctcta ctgtcttttc
     7561 aaaagccatt ttataaaaat cttaggtatt ttaatattta aatatatata tttgtgaaag
     7621 atacttttag aacgaatttt ttttaacttt aaagttcctg tattcccatt tttaagagta
     7681 aactaaagat tttccaggct taggagtatc ttttttcaga accgtgataa gaaagtcaga
     7741 ttgaggtaat aaaccagaga gtttgatgat agggaaaaag atatctggtg aggggagaca
     7801 gatttaaagg tgaaaacaat tactttgatg taacaaatta acttcttaaa taaagttttg
     7861 tggttttgct cctgtgattt cgtatttgct gctatagtag ctcactattt tatagggcta
     7921 atatataaat ctggccccat ttaaaactga ggtcctttct aatccaaaca gcctagaaag
     7981 agactgcagc acagtctgcc agcggtggcc agtgtccata tagctgatgc atgctttaat
     8041 gtttgcctgt agctggcagc acggaggtca gggaagcttc ctaccctgcc agacagagca
     8101 ttatgattct tgggggactg gcatctggga gacaagacag gccaaagagg gaaccgctga
     8161 ggagagcgtg tgaatgcagt tgcatgttcc catgttctcc tatagcagtc ctactctcca
     8221 gctgcgccag tccccatgtc accagctctg taccagttgt catctcattc aagtgtggct
     8281 ttacttggtg acagtggcca tagctaaatt acttagcatg tttgactttc tacaataaca
     8341 aaaatggtct taaatttttg ttttgatttc ctaaaaaaaa tgtacacagt gtcataactt
     8401 cacgttttat aaactagtat ctggctatta gtattttaca gaaaccatgg ttcttggtga
     8461 ctacatatat atatatatat atttttgtga cctttttgta aactaagtgc cgtttcaacg
     8521 ttacaatcat ttttagagtt attgtaatca atgtgaatat catgtttttt caaatctgtt
     8581 ctgagcctag tgtttgcttt gtgaaaaata tgtgtattgt atatattctg tatagttata
     8641 ctgtattgaa atattagctt gtttgatatg agaaaaagta tgtattgagt acctttttgc
     8701 tagcctgatt gcttaatctt ttttaaaaag gtttaatttt ttttttttaa tctttaaact
     8761 ggcctttatt aatggtcaca aataaagttg cagttagaag ggatggacag ggaaaattta
     8821 gtcttgagtg tctttggata gaaacatgag actaagattt gtttcgggtt ttttgtttgt
     8881 ttttgttttt gttttttttt tctcattaaa ataccttact gatgttttat gaaa
//
LOCUS       NM_001106817            5711 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus BCL9 like (Bcl9l), transcript variant 2, mRNA.
ACCESSION   NM_001106817 XM_001062700 XM_217124
VERSION     NM_001106817.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5711)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5711)
  AUTHORS   Deka,J., Wiedemann,N., Anderle,P., Murphy-Seiler,F., Bultinck,J.,
            Eyckerman,S., Stehle,J.C., Andre,S., Vilain,N., Zilian,O.,
            Robine,S., Delorenzi,M., Basler,K. and Aguet,M.
  TITLE     Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell
            traits in colon epithelium and adenocarcinomas
  JOURNAL   Cancer Res 70 (16), 6619-6628 (2010)
   PUBMED   20682801
REFERENCE   3  (bases 1 to 5711)
  AUTHORS   Brack,A.S., Murphy-Seiler,F., Hanifi,J., Deka,J., Eyckerman,S.,
            Keller,C., Aguet,M. and Rando,T.A.
  TITLE     BCL9 is an essential component of canonical Wnt signaling that
            mediates the differentiation of myogenic progenitors during muscle
            regeneration
  JOURNAL   Dev Biol 335 (1), 93-105 (2009)
   PUBMED   19699733
REFERENCE   4  (bases 1 to 5711)
  AUTHORS   Fritzmann,J., Morkel,M., Besser,D., Budczies,J., Kosel,F.,
            Brembeck,F.H., Stein,U., Fichtner,I., Schlag,P.M. and Birchmeier,W.
  TITLE     A colorectal cancer expression profile that includes transforming
            growth factor beta inhibitor BAMBI predicts metastatic potential
  JOURNAL   Gastroenterology 137 (1), 165-175 (2009)
   PUBMED   19328798
REFERENCE   5  (bases 1 to 5711)
  AUTHORS   Adachi,S., Jigami,T., Yasui,T., Nakano,T., Ohwada,S., Omori,Y.,
            Sugano,S., Ohkawara,B., Shibuya,H., Nakamura,T. and Akiyama,T.
  TITLE     Role of a BCL9-related beta-catenin-binding protein, B9L, in
            tumorigenesis induced by aberrant activation of Wnt signaling
  JOURNAL   Cancer Res 64 (23), 8496-8501 (2004)
   PUBMED   15574752
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062700.1, XM_217124.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..5711
                     /gene="Bcl9l"
                     /note="BCL9 like"
                     /db_xref="GeneID:300673"
                     /db_xref="RGD:1309096"
     exon            1..662
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    640..642
                     /gene="Bcl9l"
                     /note="upstream in-frame stop codon"
     exon            663..719
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            720..821
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..5127
                     /gene="Bcl9l"
                     /note="isoform 2 is encoded by transcript variant 2;
                     B-cell CLL/lymphoma 9-like protein"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 9-like protein isoform 2"
                     /protein_id="NP_001100287.1"
                     /db_xref="GeneID:300673"
                     /db_xref="RGD:1309096"
                     /translation="MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKL
                     TNHGKTGNGGAQSQHQNVNQGPTCNLGSKGVGAGSHGAKANQISPSNSSLKNPQAGVS
                     PFSSLKGKVKRERSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEW
                     CSGPDSEEDDKPIGATHNCNVADPAMVAPQLGPGQTAQLPLSENSAPGPQHGPPPGLR
                     PDVPGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRAESILAYHQQNVPRAKLDQ
                     APKVPPTPEPLPLNTPSAGTPQSQPPPLPPPPPAPGSAPPALPQEGPPEDTSQDLAPN
                     SVGAASTGGGTGGTHPNTPTAATANNPLPPGGDPGSAPGSALLGEATPTGNGQRNLVG
                     SEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAVEGGPPAQAPSAAQQ
                     PPSAPPPGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPQGGDMGQQMNMMMQRLGQD
                     SLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGGRPLQDMVGMGGNQMQRVPGFGGMQSI
                     PMEVPMNAMQRPVRPGMAWNEDLPPIGGPSNFAQNAVPYPGGQGEAERFMTPRVREEL
                     LRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMIQTHRQMDPTMFPGQMTGGDGLAGT
                     PMGIEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQM
                     LMSQKMRGPGDMMGPQGLSPEEMARVRAQNSSGMMAGPQKMLMPSQFPNQGQQGFSGG
                     QGPYQAMPQDMGNTPDMFSPDQSSVPMGAVGTARLSHMPLPPASNPPGSVHSAPNRGL
                     GRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSAN
                     PPGPLKSPQVLSSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQP
                     PLNINSSSTLGNLEQGALPPAGPRNSSSAPPANPPSSLMNPSLPFTSSPDPTPSQNPL
                     SLMMSQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNNQP
                     NQMHMNPAAAQSPMGMNLPGQQPLSHEPPPTMLPSPTPLGSNIPLHPNAQGTGGPSQN
                     SMMMAPGGPDSLNTPCGPVPSSSQMMSFPPRLQQPHGAMAATGGGGPGLQQHYPSGMA
                     LPPEDLPNQPPGPIPSQQHLMGKGMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTP
                     TGIPEFDLSRIIPSEKPSSTLQYFPKNENQPPKAQPPNLHLMNLQNMMAEQAPSRPPN
                     LPGQQGVQRGLSMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFM
                     LMKQRGVGGEVYTQPPHMLSPQGSLMAPPPQQNLMVSHPLRQRSVSLDSQMGYLPTPG
                     GMANLPF"
     misc_feature    1978..2088
                     /gene="Bcl9l"
                     /note="B-cell lymphoma 9 protein; Region: BCL9; pfam11502"
                     /db_xref="CDD:431912"
     misc_feature    1978..2088
                     /gene="Bcl9l"
                     /note="B-cell lymphoma 9 protein; Region: BCL9; pfam11502"
                     /db_xref="CDD:431912"
     misc_feature    <3304..4695
                     /gene="Bcl9l"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3304..4695
                     /gene="Bcl9l"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            822..1207
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1327
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1538
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1623
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..2446
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..3757
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..4039
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..5711
                     /gene="Bcl9l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagtgga ggggcgagcg tggctccggc agcgcagggg atcccgggga ggcggcggcg
       61 cgcggcggag ccagtggccg gacatgcccc ggatccgggg ccgctgcagc accgccgccg
      121 cccggagcca gccggccgga cgcccgcacg cctgggtccc ctggcgccgc gccgcccggg
      181 ggctgcgatc tggaccctcg gcatccgacc aacaataagc gcctagacag ccccctcccc
      241 gccccgtgcc cgccgtcccc gcgggcctcg gggaaagtga aaggaggagg cgaaggaagg
      301 aaggaaggaa ggaagggagg aggaggagca ggagcggcag cagccggagc tgggaggttt
      361 gggccgagac cccagcccgg agcccgggca cggcggtgcg gtagctctcc cgctgctgcc
      421 ggcgcccagg accatgctcc gcggttggga ggcaggaacc caggcaacca gcgcctccgg
      481 gatacctgct cgcgggccgg gctggtatta agatcaaggc gtccaggatc aaaaagacca
      541 ccgcctgccc gccttctcca cgactccacc gtcctgctgg aggatcccag tccacccaac
      601 gaccctgatc tggttatggc gtccagctcc ggcctggcgt gaggaccccc gaccggtgcg
      661 agggagcccc catcccagac cacacccctg agcctgaacc tgacacacat tcctcagagt
      721 ccctgctcca gtaccgagta cctggctggg ccctgggcac gcacaggggt cgtagcccca
      781 ctgtgtgtgg gagccatgag gatcctggct aacaagacaa ggttacccca ccccaggagg
      841 agagaggctc cagggagtcc accgctgtcc cctcgaggcc actgcccccc tgccccagcc
      901 aagccaatgc acccagaaaa taaattgacc aatcatggca agacagggaa tggaggggcc
      961 caatcccagc accagaatgt gaaccaagga cccacctgca acctgggctc caagggcgtg
     1021 ggggcgggga gccatggggc caaggccaac cagatctcac ccagcaactc aagtctgaag
     1081 aacccccagg caggagtgtc tcctttcagc tccctcaaag gcaaggtgaa gcgagagcgg
     1141 agtgtgtccg tggactctgg agagcagcga gaagccggaa ctccatccct ggattcagag
     1201 gccaaagagg tggcaccccg gagtaaacgg aggtgtgtgc tggagcggaa gcagccatac
     1261 agtggggatg aatggtgctc tggaccagac agcgaggagg acgacaagcc cattggggcc
     1321 acccacaatt gtaatgtagc agacccagcc atggtggccc cacagttggg tcctggccaa
     1381 actgcccaac tgcccctcag tgagaacagt gcaccaggcc cccaacatgg ccccccgcca
     1441 ggccttcggc cagacgtccc tgggggtggg ggtgggggcg tcccaggaaa gcctccgtct
     1501 cagttcgtgt acgtcttcac cacccatctg gccaacacgg cggcagaagc agtgctacag
     1561 ggccgggcag agtccatcct cgcctaccac cagcagaacg tgccccgggc caagctggat
     1621 caggccccta aagtgccacc caccccagaa ccactacccc tgaacacgcc atcagcaggt
     1681 acaccacagt cccagccacc tccgttgcca ccgccaccac cagcccctgg cagtgcccct
     1741 cctgctctgc cccaggaggg gcctcctgaa gacaccagtc aggacctggc ccccaactca
     1801 gtgggagctg ccagcacagg tggtgggact gggggcaccc accccaacac cccaacggct
     1861 gccactgcta acaaccctct gcctcctgga ggagaccctg gcagtgctcc tggctctgcc
     1921 ctattgggcg aggccacgcc cacaggaaat gggcagagga acctggtggg ctctgagggc
     1981 ctgtccaaag agcagctgga gcaccgtgag cgctccctcc agacacttcg agacatagag
     2041 aggctgctgc tccgcagcgg ggagactgag cccttcctca aggggccccc tggaggagct
     2101 gttgagggag gcccgcccgc acaagcgccc tctgccgctc agcagcctcc ctccgcccct
     2161 cctccggggc tgaagaagta cgaggaacct ctgcagtcaa tgatttcaca gacacagagc
     2221 cttggaggcc ccccattgga gcacgaggtg ccggggcacc ctcagggcgg agacatggga
     2281 cagcaaatga acatgatgat gcagaggctg ggccaggaca gtctgacacc tgagcaggtg
     2341 gcctggcgca aactgcagga agagtactac gaggagaagc ggcggaaaga ggagcagatt
     2401 ggattgcatg ggggccgccc tctgcaggac atggtgggaa tggggggcaa ccagatgcaa
     2461 agggtgcctg gctttggagg tatgcagagt atacccatgg aagtacccat gaatgccatg
     2521 cagagacctg taaggccggg catggcctgg aatgaagact tgccccctat tgggggaccc
     2581 agcaactttg cccagaatgc tgtgccctat ccaggtgggc agggtgaggc agagcggttc
     2641 atgacccctc gtgtccggga ggagctgctg aggcaccagt tgctggagaa gcggtcaatg
     2701 ggcatgcagc ggcccctggg catggcgggt agtggcatgg gacagagcat ggaaatggaa
     2761 cggatgatac agacacatcg acagatggac cctaccatgt tcccagggca gatgactgga
     2821 ggagatggtc tggctggcac tcccatgggc atagagttcg gtggaggccg gggcctcctg
     2881 agccctccaa tgggacagtc tgggctgagg gaggtagacc cacccatggg accgggcaac
     2941 ctcaacatga acatgaatgt caacatgaac atgaacatga acctgaatgt gcagatgacg
     3001 ccacagcagc agatgctgat gtcacagaag atgcgaggcc ctggagacat gatgggtcct
     3061 cagggcctca gtcctgagga gatggctcga gttcgggccc agaacagtag tggcatgatg
     3121 gcgggtccac agaagatgct catgccttct cagtttccca accagggcca gcagggattc
     3181 tctgggggcc agggacccta ccaagccatg ccccaggaca tgggcaacac tccagacatg
     3241 tttagccctg atcagagttc agtgcccatg ggcgctgtgg gcaccgcccg gctcagccat
     3301 atgcctctgc cccctgcatc caatccccct gggtctgtgc actcagcccc caataggggg
     3361 cttggcaggc ggccttcaga tctcaccatc agtattaatc agatgggctc accaggcatg
     3421 gggcatctga agtcacccac ccttagccag gtgcactccc cgctggtcac ctcaccctct
     3481 gccaacctta agtcacccca gactccctca cagatggtac ccttgccttc tgccaaccca
     3541 ccaggacctc tcaagtcacc ccaggtcctc agctcttccc tcagtgtgcg ttcacccact
     3601 ggctcaccca gcaggctcaa gtctccctcc atggcggtgc cttctccggg ctgggtcgcc
     3661 tctcccaaga cagccatgcc tagtcctggg gtctcccaga ataaacagcc acctctcaac
     3721 ataaactctt cctctaccct gggcaacctg gaacagggtg ctctcccacc tgctggcccc
     3781 cggaacagct cctcagctcc tcccgccaac cctcccagca gcctcatgaa tcccagccta
     3841 ccgttcacat cctccccaga ccccacgcct tcccagaacc ctctgtcact gatgatgtct
     3901 cagatgtcca agtatgccat gcccagctct accccgctgt accacaatgc catcaagacc
     3961 atcgccacct cagatgacga gttgctgcct gaccggcccc tgctaccccc acccccacca
     4021 ccgcagggct ctgggccagg tatcagcaac aaccagccca accagatgca tatgaaccct
     4081 gctgctgccc agagccccat gggcatgaac ttgccaggcc agcagcccct gtcccatgag
     4141 cctccaccta ctatgttgcc ctcccccacc cctctggggt ccaacattcc actgcacccc
     4201 aatgcacagg ggactggggg cccttctcaa aactcaatga tgatggcccc aggaggccca
     4261 gactccctaa ataccccttg tggccctgtg cccagctctt cccagatgat gtcctttcct
     4321 cctcggctgc agcaacccca tggtgccatg gccgccactg ggggtggggg gcctggcctg
     4381 cagcagcact acccttcagg catggccctg ccccctgagg acctgcccaa ccagccacct
     4441 ggtcccatac cctcccagca gcacctgatg ggcaaaggca tggctggccg catgggcgat
     4501 gcgtacccac cgggggtact ccctggggtg gcatcggtac tgaatgaccc agagctgagt
     4561 gaggtgatcc ggcccacccc taccggcatt cctgagttcg acttatccag aatcatcccc
     4621 tctgagaaac cgagcagcac cctccaatac ttccccaaga acgagaacca gccccccaag
     4681 gcccagcccc ccaatctgca cctcatgaac ctgcagaaca tgatggcgga gcaggccccg
     4741 tctcggcccc ccaacctccc aggccaacag ggggtccagc ggggtctcag catgtccatg
     4801 tgccaccctg gacagatgtc cttgctgggc aggacaggtg tgcccccaca gcagggcatg
     4861 gtgccccacg gcctgcacca gggggtcatg tcccctccac agggcctcat gacccagcag
     4921 aattttatgc tgatgaaaca gaggggcgtg gggggtgagg tctacaccca gcctccccac
     4981 atgctctccc cacagggctc cctcatggcc cccccacccc agcagaacct catggtgtcc
     5041 caccctctgc ggcagcgcag tgtgtctctg gacagccaga tgggctacct cccaacgccg
     5101 ggcggcatgg ccaatctacc cttctagcag gcccctcggt ttggagctgg ggatactgaa
     5161 aatacgttaa ctttaaaaag ttttgctttt cctccagtgt tgggatggat ggcctgggtc
     5221 caggggtagg gtggagggga gggatagggc ttgtgtgggg agtggcgttt gtggaaacct
     5281 gatgtgctgg cagcttaggg ggggagcggc aagtgtcggt gaggagttgg aattggggtt
     5341 tgctccattt ctgacaccag gaccgctcct ccccggcccc cctagtccca cggagcttct
     5401 gttccccgtc gtctttgccc ctccccgctt tcagctgtgt ttcgggggtc cttggggaga
     5461 gaggagggtc ttccatcctc tgacctgttg tggacaggtc ggtttctctc cgccgggtct
     5521 ctctgctttg accccgtttt ccttctgcct catttcctct ccctactgac gtggctgacc
     5581 tcctctccca cgccccctgc aggcagctgg ccaggtgggc aggtgtcagc ggagctgtaa
     5641 atagagctgc gcttttgtgc cggtttgtgc gtgtgccgta tttctgtgtt ttgatagaag
     5701 tcacacacaa g
//
LOCUS       NM_001436550            2638 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus neurexophilin and PC-esterase domain family,
            member 1 (Nxpe1), transcript variant 1, mRNA.
ACCESSION   NM_001436550 XM_006243018
VERSION     NM_001436550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006243018.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22782.1,
                                           SRR26643292.33556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000008.1  57647658-57647783
            127-235             JAXUCZ010000008.1  57657938-57658046
            236-1032            JAXUCZ010000008.1  57659095-57659891
            1033-1094           JAXUCZ010000008.1  57662970-57663031
            1095-1307           JAXUCZ010000008.1  57668522-57668734
            1308-2638           JAXUCZ010000008.1  57668950-57670280
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2638
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="neurexophilin and PC-esterase domain family, member
                     1"
                     /db_xref="GeneID:500992"
                     /db_xref="RGD:1566243"
     exon            1..126
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="upstream in-frame stop codon"
     exon            127..235
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1843
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /codon_start=1
                     /product="NXPE family member 1"
                     /protein_id="NP_001423479.1"
                     /db_xref="GeneID:500992"
                     /db_xref="RGD:1566243"
                     /translation="MWIMFSTIMRQKRLLIFTSFLVVIWVIFVISQNSAKLWTTLNTS
                     TSFNPWTTSTKSSPPEIPMNQSTLPTETKLREEIPKMTGHQEDKSPTETELKVREILE
                     KLDGQIPPRPFAHLNNTTSATHSTATILNPQDTYCVGDQLDVLLAAKDYFGHRKEYGG
                     DFLRARMSSPALKAGASGKVTDFNNGTYLISFTLFWEGQVSLSILLMHPSEGVSALWR
                     ARNQGYGRIAFKGTFVNGTSKVTAECGLILNSSSELCKYLYRGGEEVFYCVKPQHMPC
                     EALTYVCTSHQDVSYLTAKEKNLFQKSNIGVEMMKHPKYIVVSQCNKSENGRKRCEIG
                     MEIPTPSGYTLQGRWVSAQCTQRLLTSSQINDCLKGKLIYLLGDSTLRQWIEYLPKVA
                     KTLRPFDLHGTGLYKKHLILDAERHTLVEWKKHSHPFITVQLYSVIDDGYIPQEIDRL
                     PGDKDTVIVITVGQHFRPFPMELFVHRVINIQKAIGRLFLRSPDTKVIIKMENIRERN
                     LDTEKFGDFHGYVQYLTTKEIFKDLHVGTIDAWDMTIAHGTNVLHPPAAVIGNQIDVF
                     LNYIC"
     misc_feature    <590..955
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="Region: Neurexophilin; pfam06312"
                     /db_xref="CDD:428882"
     misc_feature    <590..955
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /note="Region: Neurexophilin; pfam06312"
                     /db_xref="CDD:428882"
     exon            236..1032
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1094
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1307
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2638
                     /gene="Nxpe1"
                     /gene_synonym="RGD1566243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgcat gaaggttggg ccagagagct ccagggccag cctcagcttc tgagtcaaca
       61 ctcatgctcc ttgctgcctt gggcatcgta gatgcagctg ccttagagtc acacgtgttc
      121 ctttctgatg tggatcatgt tctccactat catgcgtcag aagaggctgc taatattcac
      181 atcgttttta gtggttatct gggtaatatt tgtaatctcc caaaattctg caaagctatg
      241 gaccactcta aacacatcca catccttcaa tccctggacc acatccacga agtcctcacc
      301 tcctgaaatt ccaatgaacc agtcaacgtt accaacagag accaagctaa gagaggagat
      361 ccctaagatg acaggccacc aagaagacaa gtcaccaaca gagacagagc tgaaagtcag
      421 ggagatcctg gagaagctag atggacagat ccctcccaga cccttcgccc acctcaacaa
      481 caccacaagt gccacacaca gcacagccac catcctcaac cctcaggata catactgtgt
      541 aggggaccag ctggatgtct tgctggcggc caaggactat tttggtcaca ggaaggaata
      601 tggtggggat ttcctgaggg ccaggatgtc ctccccagcc ttgaaggcag gagcttctgg
      661 aaaggtgaca gacttcaaca atggcaccta cctcatcagc ttcactctgt tctgggaggg
      721 ccaggtctcc ctgtctatcc tgctcatgca ccccagtgaa ggggtgtcag ctctctggag
      781 agcaaggaac caaggctatg gtagaattgc cttcaaaggg acttttgtta atggcacatc
      841 caaggtcaca gctgaatgtg gcctgatcct gaactcaagc agtgagctct gcaaatacct
      901 gtaccgtggt ggcgaggaag tcttctactg cgtgaagcct caacacatgc cctgtgaggc
      961 cctgacctac gtgtgtacca gtcaccaaga tgtttcttat ctcactgcca aagaaaaaaa
     1021 cctttttcag aagtccaaca taggagttga aatgatgaag caccctaagt atatcgttgt
     1081 ctcccagtgc aacaagagtg aaaacgggag aaagagatgt gagatcggaa tggagattcc
     1141 cacacctagc ggttacactt tacaaggaag gtgggtatca gcccagtgta ctcagcgcct
     1201 gttaacctca agtcagataa atgactgctt aaaaggaaag ctcatttacc tcctgggaga
     1261 ctccacgctt cgccaatgga tcgaatatct tcccaaggtt gcaaaaacgt tgagaccttt
     1321 tgaccttcac gggactgggc tatataagaa acatttgatt ttggatgctg agaggcacac
     1381 tctggttgaa tggaagaaac acagtcaccc tttcatcact gtccagctct actctgtgat
     1441 agatgatggc tatatccctc aggaaattga ccgcttgccg ggcgacaaag acactgtcat
     1501 agtcattacc gtgggccagc acttcagacc ctttcccatg gaactttttg ttcaccgagt
     1561 catcaacatc caaaaggcta ttggacggct cttcctcaga agccctgata ctaaagtcat
     1621 cattaagatg gagaatatta gggagaggaa cctagataca gagaaattcg gagacttcca
     1681 tggttatgtt cagtatctaa ccacaaagga gattttcaaa gaccttcatg tgggtaccat
     1741 tgatgcctgg gacatgacca tcgcacatgg taccaatgtc ctccatccac ctgctgcagt
     1801 gattggaaac cagattgacg tgtttttaaa ctacatttgc tgaagaagca tcactaggag
     1861 cccagcgctc ccagccatac cacgtgatcc atcagtgaag ttttgttcaa tgtaggatta
     1921 aaaaaaacaa acaaacaaat ttaaaagaat ctgtcatggg atagaggcga gactaagctg
     1981 agagggtgtc tgctcagtat gcacgaagct ggggttcaac cttcagcacc acataagcag
     2041 ggcacagtgg cacgtgcttg taattccaag actcgggaag atcagaagtg aaggtcatct
     2101 ttgttatata gtcaggtcca gtagagcctg ggcttcatgg gagcattcct tgattaaaaa
     2161 taatcatcat gatcgtgacg ggagacatat ctaaaaacag tgactacaga gacgaaatat
     2221 aaagccaaaa ccaccaagtg caaaggacca tcctagaaca ttctctgtct gtctctggga
     2281 tgataaaagc ctttatttgt taggcaagca tgagcaagcc tgatctctgt taatcttggc
     2341 taaaccaaaa gacaggaagt atccaagaga gcagcatgcc tttgccatca tgctctaaga
     2401 cttttttatt ttaaaaaaga caaacaaaca aacaaacaaa caaaaaaccc acaccttttc
     2461 tgcaaaagaa cagaaagtaa gtatcctagg tttggaggac cacatattta cctctgtcac
     2521 cactattcca ttctgccacc aaggcacaaa acaagacaaa catgtaagca aataaaaatg
     2581 ttcttgtttt tgttttaaaa aaaaaaacct agtaataaac accgaaaatt gaatttta
//
LOCUS       NM_001436542            1560 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus triosephosphate isomerase 1 like 1 (Tpi1l1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436542 XM_063265962
VERSION     NM_001436542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_063265962.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000008.1  31931100-31931249   c
            151-203             JAXUCZ010000008.1  31930252-31930304   c
            204-253             JAXUCZ010000008.1  31927901-31927950   c
            254-1560            JAXUCZ010000008.1  31923596-31924902   c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1560
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase 1 like 1"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
     exon            1..150
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..203
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..158
                     /gene="Tpi1l1"
                     /note="upstream in-frame stop codon"
     exon            204..253
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..989
                     /gene="Tpi1l1"
                     /EC_number="5.3.1.1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="triosephosphate isomerase 1 like 1 isoform 1"
                     /protein_id="NP_001423471.1"
                     /db_xref="GeneID:500959"
                     /db_xref="RGD:1560534"
                     /translation="MTIMELNSRKFFVGGNWKMNGKKKCLGELICTLNAAKMPADTEV
                     VCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSE
                     RRHVFGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVK
                     DWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEEVAQCTRIIYGGSVT
                     GATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ"
     misc_feature    249..980
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    249..980
                     /gene="Tpi1l1"
                     /note="triosephosphate isomerase; Provisional; Region:
                     PTZ00333"
                     /db_xref="CDD:240365"
     misc_feature    order(273..275,279..281,525..527,735..737,753..755,
                     873..875,930..932,936..941)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(273..275,279..281,525..527,735..737,753..755,
                     873..875,930..932,936..941)
                     /gene="Tpi1l1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238190"
     misc_feature    order(273..275,282..284,375..383,387..389,396..398,
                     432..434,486..488,495..500,531..536)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(273..275,282..284,375..383,387..389,396..398,
                     432..434,486..488,495..500,531..536)
                     /gene="Tpi1l1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238190"
     misc_feature    order(279..281,525..527,735..737)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
     misc_feature    order(279..281,525..527,735..737)
                     /gene="Tpi1l1"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238190"
     exon            254..1560
                     /gene="Tpi1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcagta gacgccttca gcacacaaga caaggtctct cggcagactg cagcctcttc
       61 actctggtcc acagcactgg tcctctcacc tctgtgcttt agaatccaga agattccaga
      121 tgccagtggg gcacattcaa cttgaacaag gaatttaagt aaagaattgt agaaatagaa
      181 ggtatttcta ctacattaag aagatacccg gatcctttaa ccttccgatg actattatgg
      241 aacttaattc aaggaagttc ttcgtcgggg gcaactggaa gatgaacggg aagaagaaat
      301 gcctgggaga actcatctgc accctgaacg cagccaagat gccggcagac accgaggtgg
      361 tttgtgcacc gccaaccgcc tacatcgact tcgccaggca gaagctggat cccaaaattg
      421 ctgtggctgc acagaactgc tacaaagtga ccaatggggc tttcactggg gaaatcagcc
      481 ctggcatgat caaagactta ggagctacct gggtggtgct gggacactcg gaaagaagac
      541 acgtctttgg ggaatcagac gagttgattg ggcagaaagt gaaccatgcc ctatccgagg
      601 gactcggagt gatcgcctgc attggggaga agttagacga aagggaagct ggcatcactg
      661 agaaggttgt ttttgagcaa accaaggcca tcgcagataa tgtgaaggac tggtccaagg
      721 tggtcctggc ctatgaaccg gtatgggcca ttgggactgg caagactgca acccctcaac
      781 aggcccagga agtacacgag aagctccggg gatggctgaa gtgcaacgtc tctgaggagg
      841 tggctcagtg cactcggatc atttatggag gttctgtgac tggagcgact tgcaaagagc
      901 tggcaagcca gcctgatgtg gatggcttcc tcgtgggcgg tgcatctctc aagcctgaat
      961 tcgtggacat tatcaatgcc aaacaatgag cactgctcat ccccctacct tcctgcgtag
     1021 cctggaccag gttgcccaga agtttagtaa ctgctcccgc cagtcacatg cttctgatga
     1081 catcatcaac tccatcctgt gacctattcc atactgtacc ttcctgagcc tcttacctcc
     1141 ccataatagt tgggaccagg ccaatccctt taccacttac aatgggtaaa atcaaatatg
     1201 tcaccaagat ggcttcctga ggaggggaag gagtagaact ggcagtccct ttgggcccta
     1261 atgggtgaaa acggccttcc attggtttgg gatggaaact catggctgga ccacaggaag
     1321 taggcttctt gtcactttgg cctgtcactt agatggcctt ggctctagct tcactcccaa
     1381 gccctactgg atgtgtgatg cagagattca gagtcttcag gtctgaattt cagtgtacat
     1441 taaggccaag atcctcttac tcttagaggc ctgggatatc ccctcccccg cagtgccaaa
     1501 gcccttgtat tgtgtttgtg aaccatccta cgtataaggg aaataaacac ctgggcctaa
//
LOCUS       NM_001436557            2593 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus KRI1 homolog (Kri1), transcript variant 1, mRNA.
ACCESSION   NM_001436557 XM_039082792
VERSION     NM_001436557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039082792.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.10979.1,
                                           SRR26643289.22298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000008.1  28107448-28107557   c
            111-184             JAXUCZ010000008.1  28107283-28107356   c
            185-290             JAXUCZ010000008.1  28106181-28106286   c
            291-402             JAXUCZ010000008.1  28105041-28105152   c
            403-457             JAXUCZ010000008.1  28101867-28101921   c
            458-507             JAXUCZ010000008.1  28101743-28101792   c
            508-604             JAXUCZ010000008.1  28101532-28101628   c
            605-682             JAXUCZ010000008.1  28101378-28101455   c
            683-801             JAXUCZ010000008.1  28100749-28100867   c
            802-928             JAXUCZ010000008.1  28100380-28100506   c
            929-1024            JAXUCZ010000008.1  28100181-28100276   c
            1025-1195           JAXUCZ010000008.1  28099260-28099430   c
            1196-1271           JAXUCZ010000008.1  28096315-28096390   c
            1272-1360           JAXUCZ010000008.1  28096140-28096228   c
            1361-1487           JAXUCZ010000008.1  28095812-28095938   c
            1488-1618           JAXUCZ010000008.1  28095596-28095726   c
            1619-1683           JAXUCZ010000008.1  28095192-28095256   c
            1684-1782           JAXUCZ010000008.1  28095025-28095123   c
            1783-2593           JAXUCZ010000008.1  28093175-28093985   c
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2593
                     /gene="Kri1"
                     /note="KRI1 homolog"
                     /db_xref="GeneID:687183"
                     /db_xref="RGD:1588903"
     exon            1..110
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2110
                     /gene="Kri1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein KRI1 homolog isoform 1"
                     /protein_id="NP_001423486.1"
                     /db_xref="GeneID:687183"
                     /db_xref="RGD:1588903"
                     /translation="MPEPRAPATLKVNAAFAARYSRYREREELQRLKDRYGDRDDGSD
                     SSSESDSSDEHVEFDPQQERDFYRTLSLLKKKDPRIYQKDATFYQRTEASSSESEEES
                     AALGKQKKVQPMYLKDYERKVILEKEGKYVDEDNSDGESVDHRLQETATKSYIEEQRQ
                     LKESFRAFVEDSSDEDSAGEGGSGLLQKHTKSGEEKAQEDVDYLEWLKGQKEIDSSES
                     LKELTHLKEYWNNPELDEGEQFLRDYILNKRYEEDEEEETEEERVLGPPVQLAVDDSS
                     DEGELFLKKQEDFEHKYNFRFEEPDSASVKTYPRSIASSVRRKDDRRKEKREETRERK
                     KREKAKKQEELKQLKNLKRKEILAKLEKLRQVTGNETLGLEEQDLEDDFDPAQHDQLM
                     QKCFGDAFYGTVEEEKPQFEEEEGLEDDWNWDTWGGPEQNGAWSQQELHCEDPDFNMD
                     ADYDPSQPRKKLREAPTSGKRKRKSPFAAAVGQEKPMFDPGDKTFEEYLDEYYRLDYE
                     DIIDDLPCRFKYRTVVPCDFGLSTEEILSADDKELNRWCSLKKTCMYRSEQEEMQEQR
                     AYSQKAQSVWKKRQIFKSLCQEEVEMPTEATGKSPSKASSQVQLPMPSAAGGKKPQAE
                     LSGAKEEELAHTPCPEKPASQKQKSKKARLLGPTVTLGGHKFSRQRLQAFGLNPKRLH
                     FRQLGRQRKKQQSHA"
     misc_feature    965..1294
                     /gene="Kri1"
                     /note="KRI1-like family; Region: Kri1; pfam05178"
                     /db_xref="CDD:461569"
     misc_feature    965..1294
                     /gene="Kri1"
                     /note="KRI1-like family; Region: Kri1; pfam05178"
                     /db_xref="CDD:461569"
     misc_feature    1493..1759
                     /gene="Kri1"
                     /note="KRI1-like family C-terminal; Region: Kri1_C;
                     pfam12936"
                     /db_xref="CDD:463756"
     misc_feature    1493..1759
                     /gene="Kri1"
                     /note="KRI1-like family C-terminal; Region: Kri1_C;
                     pfam12936"
                     /db_xref="CDD:463756"
     exon            111..184
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..290
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..402
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..457
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..507
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..604
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..682
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..801
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..928
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1024
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1195
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1271
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1360
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1487
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1618
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1683
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1782
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2593
                     /gene="Kri1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtctcaca gccgccatgc cggaaccgcg cgctcctgcg actctaaagg tgaacgcagc
       61 ttttgctgca cgctacagcc gttaccgcga gcgtgaggaa ctacagcggc tgaaagatcg
      121 ctacggagat cgggacgacg gcagcgactc cagttccgag tctgactcca gcgatgagca
      181 tgtggaattt gatccccagc aggagagaga cttttataga actctgtcct tgttgaagaa
      241 gaaagaccct cgaatttacc agaaagatgc taccttctat cagagaacag aagcctcctc
      301 ttcagagagt gaggaggagt cagcagcctt gggaaagcag aagaaagtac agcccatgta
      361 cctgaaggac tatgagagga aggtcatctt ggagaaagaa ggcaaatatg tggacgagga
      421 caactctgat ggggagagcg ttgatcacag gctccaggaa acagccacaa agagttacat
      481 agaagagcag agacagctga aggaaagctt ccgtgccttt gtggaggaca gcagcgatga
      541 ggacagtgcc ggggaaggtg gctctgggct gctgcagaag cacactaaga gtggggaaga
      601 aaaggcccag gaggatgtgg actacctgga gtggctaaag gggcaaaagg agatcgacag
      661 ctctgagtcg ctgaaagaac tgacacacct caaggagtac tggaacaacc cagaactgga
      721 cgagggggag cagttcctga gggattatat cctcaacaaa cgctatgaag aggacgagga
      781 ggaggagaca gaggaggaaa gggttctggg ccccccagtg cagctggcgg tggacgactc
      841 ctcagatgaa ggggagctat tcctgaagaa gcaggaagac tttgaacaca agtacaactt
      901 ccgctttgag gagcctgact cagcctcagt caagacatac ccgcggagca tcgcgtcgtc
      961 tgtgcgtcgc aaggacgacc gcaggaagga gaagagggag gagaccaggg agcggaagaa
     1021 gagggagaaa gccaagaagc aggaggagct gaaacagttg aagaacctca agaggaagga
     1081 gattctagcc aagctggaga agctgcgcca ggtcactggc aacgagacat tgggccttga
     1141 ggagcaggac ctggaggatg actttgaccc tgcccagcac gaccagctca tgcagaaatg
     1201 ctttggagat gccttctacg ggactgtgga agaagagaag ccacagtttg aggaagagga
     1261 ggggctggaa gatgactgga actgggacac gtggggtgga cctgagcaga atggggcctg
     1321 gagccaacag gagctgcact gtgaggaccc tgactttaac atggatgcag actatgatcc
     1381 cagccaacct cggaagaagc ttcgtgaagc ccccacctca ggcaagagaa agcgcaagtc
     1441 tccgtttgca gctgcagtgg ggcaggagaa gcccatgttt gaccctgggg acaagacctt
     1501 tgaggagtac ctggatgaat actacaggct ggactatgag gacattattg acgacctgcc
     1561 ttgtcgcttc aagtaccgca ctgtcgtccc ctgtgacttt gggctcagca cagaggagat
     1621 cctttcagct gatgacaagg aactgaatcg ctggtgttcc ctgaagaaga cctgcatgta
     1681 caggtcggag caggaagaga tgcaggagca gcgggcgtac agccagaagg cccagagcgt
     1741 gtggaagaag aggcagatct tcaagtctct gtgccaggaa gaggtggaaa tgcccacaga
     1801 agccacagga aagtcaccca gcaaggccag ctcacaagtc cagctgccca tgcccagtgc
     1861 agctgggggg aagaagcccc aggctgagct ctcaggagcc aaggaagaag agttggccca
     1921 cacaccctgc ccagagaagc cagcatccca gaagcagaag agtaagaagg ccaggctgct
     1981 gggtcccaca gtgacacttg gaggtcacaa gttcagccga cagagattgc aggcctttgg
     2041 cctcaacccc aaaaggctgc acttccgcca gttgggtcgc caacgcaaga aacagcagag
     2101 ccacgcctga gggccacagg gagccaacct gcctcccggg ctaagctgct gaccatactc
     2161 cgcctgttgg cctagggaag ctgcctgcag cgggggcacc gctgcttcta agctggggaa
     2221 ctgaggctgc cagagccttg tcttcccaca gacaacctga aagtcacaac cacaggcaca
     2281 ctcaagtctg catgtttatc agcctccact gacagtcagt cagtcctccc agtcatccag
     2341 cgcaggctac agaacttgaa tcaggccctg agtgagtgcc ccggagccca ctccatcccc
     2401 ggctcctgag gagtcagggg cagctggggg tgaggactcg aaagggcaca accccaagct
     2461 gggggcctag ataggtctca gctgtgttgg ggaggatcgg ggacatgagg acaggggtcc
     2521 agcaccacct ctggagttcc agatcccata cctgacatga cataaataaa aaaataaata
     2581 gtctggcatc ttt
//
LOCUS       NM_001436561            2494 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 25 (Tmem25), transcript
            variant 1, mRNA.
ACCESSION   NM_001436561 XM_006242959
VERSION     NM_001436561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Zhang,H., Tian,X., Lu,X., Xu,D., Guo,Y., Dong,Z., Li,Y., Ma,Y.,
            Chen,C., Yang,Y., Yang,M., Yang,Y., Liu,F., Zhou,R., He,M., Xiao,F.
            and Wang,X.
  TITLE     TMEM25 modulates neuronal excitability and NMDA receptor subunit
            NR2B degradation
  JOURNAL   J Clin Invest 129 (9), 3864-3876 (2019)
   PUBMED   31424425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006242959.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1596647.1,
                                           SRR26643429.29968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000008.1  54009314-54009377   c
            65-161              JAXUCZ010000008.1  54008719-54008815   c
            162-473             JAXUCZ010000008.1  54008159-54008470   c
            474-764             JAXUCZ010000008.1  54006503-54006793   c
            765-896             JAXUCZ010000008.1  54006205-54006336   c
            897-927             JAXUCZ010000008.1  54005871-54005901   c
            928-1028            JAXUCZ010000008.1  54005600-54005700   c
            1029-1115           JAXUCZ010000008.1  54005420-54005506   c
            1116-2494           JAXUCZ010000008.1  54003907-54005285   c
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2494
                     /gene="Tmem25"
                     /note="transmembrane protein 25"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
     exon            1..64
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            65..161
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1189
                     /gene="Tmem25"
                     /codon_start=1
                     /product="transmembrane protein 25 precursor"
                     /protein_id="NP_001423490.1"
                     /db_xref="GeneID:689172"
                     /db_xref="RGD:1596132"
                     /translation="MELPLSQATLRHTLLLLPALLSSGQGELAPQIDGQTWAERALRE
                     NEHHAFTCRVAGGSATPRLAWYLDGQLQKATTSRLLSVGGDAFSGGTSTFTVTAQRSQ
                     HELNCSLQDPGSGRPANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPP
                     ANVTWIDQDGPVTVNASDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTS
                     ASLPAPGLLATRIEVPLLGIVVAGGLAFGTLVGFSTLVACLVCRKEKKTKGPSRRPSL
                     ISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDIRGKATERPMAQHSSRPELLEAEP
                     GGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL"
     sig_peptide     92..169
                     /gene="Tmem25"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    170..445
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    170..445
                     /gene="Tmem25"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    233..247
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    233..247
                     /gene="Tmem25"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    275..289
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    275..289
                     /gene="Tmem25"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    362..373
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    362..373
                     /gene="Tmem25"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    401..418
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    401..418
                     /gene="Tmem25"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     exon            162..473
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            474..764
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            765..896
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            897..927
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1028
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1115
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..2494
                     /gene="Tmem25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgtact gcggcgctca gcgacttgag caattgctgg ggctctgctc caggagggag
       61 ccagcagcct ggaggccagt ccctgatcac catggagttg cctctaagcc aagctacgct
      121 ccggcatact ctgctgctcc tgcctgccct cttaagttca ggtcaaggag agctggcgcc
      181 acaaattgat ggtcagacct gggctgagag agcacttagg gaaaatgagc accatgcttt
      241 cacctgtcgg gttgcagggg gttctgccac tccccgatta gcctggtacc tggatggaca
      301 gctacagaag gctaccacct cgcgactcct gagtgtgggc ggggacgcct tctctggagg
      361 taccagcact ttcactgtca ctgcccagcg ctcccaacat gagcttaact gctccctgca
      421 ggacccaggg agtggccggc cagccaatgc ctctgtcatt ctcaatgtgc aattcaaacc
      481 agagattgcc caggttggag ccaagtacca ggaagctcag ggcccaggcc ttctggttgt
      541 cctgtttgcc ctggtacggg ccaacccacc tgccaatgtc acctggattg accaggatgg
      601 gccagtgact gtcaatgcct ctgacttcct ggtgctggat gcccagaact atccctggct
      661 caccaaccac actgtgcagc tgcagctccg aagcctggca cacaacctct cggtggtggc
      721 caccaacgat gtgggtgtca ccagtgcctc acttccagct ccagggctcc tggccacacg
      781 gatagaagtg ccactgctgg gcatcgttgt ggctggagga cttgcctttg gcactctagt
      841 gggattcagt accttggtgg cctgcctggt ctgcaggaaa gagaagaaaa caaaaggccc
      901 ctcccggcgt ccttctctga tatctagtga ctccaataac ctgaaactga ataatgtgcg
      961 cctgccccgg gagaacatgt ccctcccatc caaccttcag ctcaatgacc tcactccgga
     1021 tatcagaggg aaagcaacag agcggccaat ggctcagcat agcagccgtc cagagcttct
     1081 agaagcggag cctggtggcc tcctcaccag ccgaggtttc atccgtctcc caatgttggg
     1141 ctacatctac cgtgtgtcca gcgtaagcag tgatgagatt tggctctgag cttgagagtg
     1201 aggcagatgg cccaggtggt ctgtggactc cccagagtga ccaccccttc ttgaagcatc
     1261 ttcttcaagc ttccctctgc ctggccctgt tgtgaccatg aagaaaccat gtcactgccg
     1321 tctggcctgc ctggcaagga tacctgtggg tcatgcatgt gtatgtcatt gcactctaac
     1381 ctgcaagaca tgggtaccct tggcaaggcc acgggtcaga actaagcccc ttgcactcac
     1441 tcagtttggg gccctgcatg tgataacctg gtccaggcag acggaactct ggccaggtgt
     1501 gtttagatgt cacccgacac ctaaaagacg ggcctattta ttatacgtcc cacgccagta
     1561 tccactgcac cttgtgtgca gagagatgcc tatgcagggg accccgcaca actcagatga
     1621 cagccttcct ttgctatgca gccttgttcc ctcagggaaa acatagcccc tgctattgta
     1681 tagaaccaaa ttgccctttg ctcaggaacc agcccctcac ccagggacct ggccaagcac
     1741 aaattcgtcc cttttgctgc aacatatctt tctactcttc tatccccact tcctcttggt
     1801 catcataggt cataccctag accttcttca ctgagtatta gacctccatt ggctggggcc
     1861 catgggtgca gcctttggtg ttagcacaag atgagcaaga agaggtgaca ggagggctgg
     1921 ctcccaagac agcatgtagc aatgtatcat tttgtacagt gtcctcatat taagcacatt
     1981 ctccaggagc gaggagggcc cagggccttc ttgggttccc catctttggc cttcagcaat
     2041 tcactgtgag tgttctgagc actcagggtt ggtggtttcc tctctgcatg tctcttccca
     2101 ccatgcagcc acattcctga ccaaacctgg ctgccacatc ctattcttcc agggatggtc
     2161 acagtgggta tagaacccaa cagcgccaga agctttaggg gaacagaggg agcaggagcc
     2221 cacacagctc taaagagcta agaatacttt taaaaaagca acatgaaaat ggcaaacagg
     2281 ggttggggat ttagctcagt ggtagagcgc ttgcctagca agcgcaaggc cctgggttca
     2341 gtccccagct ctggaaaaaa aaaaaaaaaa aaagaaagaa aatggcaaac agcagagtat
     2401 ggagtctatt ttcctttctt catatcttgt ttggtaattt ttcttgtgtt actggtgagt
     2461 actgtgctgc acacacagta aattcctttg acca
//
LOCUS       NM_001436536            1868 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus nei-like DNA glycosylase 1 (Neil1), transcript
            variant 1, mRNA.
ACCESSION   NM_001436536 XM_039081873
VERSION     NM_001436536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   Ma,H., Wang,J., Abdel-Rahman,S.Z., Hazra,T.K., Boor,P.J. and
            Khan,M.F.
  TITLE     Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced
            splenic toxicity
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 1-7 (2011)
   PUBMED   21145906
  REMARK    GeneRIF: In the spleen aniline-induced oxidative stress is
            associated with an induction of NEIL1/2.
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Das,A., Boldogh,I., Lee,J.W., Harrigan,J.A., Hegde,M.L.,
            Piotrowski,J., de Souza Pinto,N., Ramos,W., Greenberg,M.M.,
            Hazra,T.K., Mitra,S. and Bohr,V.A.
  TITLE     The human Werner syndrome protein stimulates repair of oxidative
            DNA base damage by the DNA glycosylase NEIL1
  JOURNAL   J Biol Chem 282 (36), 26591-26602 (2007)
   PUBMED   17611195
REFERENCE   3  (bases 1 to 1868)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_039081873.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.33801.1,
                                           SRR26643289.23054.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000008.1  66451967-66452196   c
            231-687             JAXUCZ010000008.1  66450320-66450776   c
            688-807             JAXUCZ010000008.1  66448599-66448718   c
            808-871             JAXUCZ010000008.1  66448447-66448510   c
            872-971             JAXUCZ010000008.1  66448117-66448216   c
            972-1099            JAXUCZ010000008.1  66447489-66447616   c
            1100-1127           JAXUCZ010000008.1  66447254-66447281   c
            1128-1189           JAXUCZ010000008.1  66447036-66447097   c
            1190-1346           JAXUCZ010000008.1  66446761-66446917   c
            1347-1868           JAXUCZ010000008.1  66446106-66446627   c
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1868
                     /gene="Neil1"
                     /note="nei-like DNA glycosylase 1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
     exon            1..230
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    110..112
                     /gene="Neil1"
                     /note="upstream in-frame stop codon"
     exon            231..687
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1417
                     /gene="Neil1"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 1; nei endonuclease
                     VIII-like 1"
                     /codon_start=1
                     /product="endonuclease 8-like 1"
                     /protein_id="NP_001423465.1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
                     /translation="MPEGPELHLASHFVNEICKGLVFGGCVEKSSVSRNPEVPFESSA
                     YHISALARGKELRLTLSPLPGSHPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFY
                     TAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRLSPELTLSQKVKA
                     KLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYAVPGMSSLRDRHG
                     RTIWFQGDPGPLAPKGGRSRKKKSQETQLEAEDRKEDPPSKSISRTQRARKHCPKNVP
                     QQSEGASLPQNLETPAVPEKGKRRGRRASTGRHRGPKSKPDTQPREAGEISAS"
     misc_feature    254..634
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    254..634
                     /gene="Neil1"
                     /note="N-terminal domain of Fpg (formamidopyrimidine-DNA
                     glycosylase, MutM)_Nei (endonuclease VIII) base-excision
                     repair DNA glycosylases; Region: FpgNei_N; cl03119"
                     /db_xref="CDD:470740"
     misc_feature    order(257..262,413..415,485..487,491..499,536..541)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    order(257..262,413..415,485..487,491..499,536..541)
                     /gene="Neil1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176801"
     misc_feature    257..259
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    257..259
                     /gene="Neil1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(260..271,275..280,287..289,404..418)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(260..271,275..280,287..289,404..418)
                     /gene="Neil1"
                     /note="H2TH interface [polypeptide binding]; other site"
                     /db_xref="CDD:176801"
     misc_feature    order(260..262,413..415)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    order(260..262,413..415)
                     /gene="Neil1"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:176801"
     misc_feature    <407..>871
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    <407..>871
                     /gene="Neil1"
                     /note="DNA-formamidopyrimidine glycosylase; Region: fpg;
                     TIGR00577"
                     /db_xref="CDD:273150"
     misc_feature    1007..1123
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     misc_feature    1007..1123
                     /gene="Neil1"
                     /note="Endonuclease VIII-like 1, DNA bind; Region:
                     Neil1-DNA_bind; pfam09292"
                     /db_xref="CDD:462745"
     exon            688..807
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..871
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..971
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1099
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1127
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1189
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1346
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1868
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcctggct aggttaactg gtgacttcaa ctgcagacgc agctgcgact cctggcacca
       61 gttctgaccg aggctctgct caccgtaaga cgggttcttt cggtcacggt agggttcttc
      121 ctccgggtca cgcgacgtct ccaaagcttg cccaacaccc gggattttca caactaagga
      181 actccattcc atactacgcc gcctgcctga ggaactacac ttcccagcag ggcccagcca
      241 ttcctccttc agaatgccgg agggcccaga gctgcacctg gccagccact ttgtgaatga
      301 gatatgtaaa gggctggtat tcggtgggtg tgtggagaag tcctctgtca gccgaaaccc
      361 ggaggtgccc tttgagagca gtgcctacca catctcagct ttagcccgag gcaaggagct
      421 gcgcttgaca ttgagccccc tgcctgggtc ccatccccct cagaaaccac tgtcccttgt
      481 cttccgcttt ggtatgtctg gatccttcca gctggtaccc gcagaagcac tgccgcgcca
      541 cgcccatcta cgtttctata cggccccacc tgccccccgg cttgcccttt gcttcgtaga
      601 catccgccgc tttggccact gggaccctgg aggtgaatgg cagccaggcc gcggaccctg
      661 tgtcttgttg gagtatgaac ggttcagaga gaacgtgctt cggaacctat cggacaaagc
      721 ctttgaccgg cccatctgcg aggccttgtt ggaccagagg ttcttcaatg gaatcggcaa
      781 ctatctgcgg gcagagatct tgtatcggct gaagatcccc ccttttgaga aggcccgtac
      841 agttctagag gccctgcaac agtgccggct gagcccagag ctgaccctga gccagaaggt
      901 caaggccaaa ctgcagaacc cagacctgct ggaactgtgt cacttggtgc ccaaggaagt
      961 ggttcagctg gggggcaaag gctatgggcc agagcgtgga gaggaagatt ttgctgcctt
     1021 tcgagcctgg cttcggtgct atgctgtgcc aggcatgagc tccctgagag accggcatgg
     1081 ccgtaccatt tggttccagg gtgatcctgg acccttggca cccaaagggg gcagatcccg
     1141 aaaaaagaag tcacaggaaa cacagctgga ggctgaggac agaaaagagg accctccaag
     1201 caagtccatt tccaggactc agagggccag gaagcactgt cctaagaatg tacctcaaca
     1261 gtctgaaggg gccagcctcc cacaaaacct ggaaacccct gcagtccctg agaaaggaaa
     1321 gagaaggggg agacgggcga gcacaggccg ccacagagga ccaaagagta agcctgatac
     1381 tcaacccagg gaggctgggg agatttcagc ctcataggta gaggtatcct tccctgatga
     1441 cttgctatca atctagggga atgtctgaat ccctagaacc agtatttgta gggctacatg
     1501 ccctgggccc tgtgattttt ttcctgcaca actgttgtct gaggtggggt ctcctgtgtc
     1561 ctatccttga atccatatgt acctgaagat gacattgaac tcctcctgtt tgatcttcct
     1621 gcttcgtttc catggtcact gggatttgca ggtgtgagct gagccaccac accctgctga
     1681 tttgctaccg tttattttct caagacaagg gtttctctgt gtagccctgg ctgtcctaga
     1741 actcatgctg tagaccaagc tggcctcaag ctctgagatc tgcctgcttc tgcctcccaa
     1801 agtgttggaa atgtatgcta tcccaagtga aaaccattat caaattaata aatttgaact
     1861 tctcagtg
//
LOCUS       NM_001436563            3265 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus piwi-like RNA-mediated gene silencing 4 (Piwil4),
            transcript variant 1, mRNA.
ACCESSION   NM_001436563 XM_008765980
VERSION     NM_001436563.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3265)
  AUTHORS   Henaoui,I.S., Jacovetti,C., Guerra Mollet,I., Guay,C., Sobel,J.,
            Eliasson,L. and Regazzi,R.
  TITLE     PIWI-interacting RNAs as novel regulators of pancreatic beta cell
            function
  JOURNAL   Diabetologia 60 (10), 1977-1986 (2017)
   PUBMED   28711973
REFERENCE   2  (bases 1 to 3265)
  AUTHORS   Sivagurunathan,S., Palanisamy,K., Arunachalam,J.P. and
            Chidambaram,S.
  TITLE     Possible role of HIWI2 in modulating tight junction proteins in
            retinal pigment epithelial cells through Akt signaling pathway
  JOURNAL   Mol Cell Biochem 427 (1-2), 145-156 (2017)
   PUBMED   28025795
REFERENCE   3  (bases 1 to 3265)
  AUTHORS   Yang,Z., Chen,K.M., Pandey,R.R., Homolka,D., Reuter,M.,
            Janeiro,B.K., Sachidanandam,R., Fauvarque,M.O., McCarthy,A.A. and
            Pillai,R.S.
  TITLE     PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
            Cytosolic Targets of the Mouse piRNA Pathway
  JOURNAL   Mol Cell 61 (1), 138-152 (2016)
   PUBMED   26669262
REFERENCE   4  (bases 1 to 3265)
  AUTHORS   Pastor,W.A., Stroud,H., Nee,K., Liu,W., Pezic,D., Manakov,S.,
            Lee,S.A., Moissiard,G., Zamudio,N., Bourc'his,D., Aravin,A.A.,
            Clark,A.T. and Jacobsen,S.E.
  TITLE     MORC1 represses transposable elements in the mouse male germline
  JOURNAL   Nat Commun 5, 5795 (2014)
   PUBMED   25503965
  REMARK    Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604.
            PMID: 26159654]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3265)
  AUTHORS   Keam,S.P., Young,P.E., McCorkindale,A.L., Dang,T.H., Clancy,J.L.,
            Humphreys,D.T., Preiss,T., Hutvagner,G., Martin,D.I., Cropley,J.E.
            and Suter,C.M.
  TITLE     The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in
            somatic cells
  JOURNAL   Nucleic Acids Res 42 (14), 8984-8995 (2014)
   PUBMED   25038252
REFERENCE   6  (bases 1 to 3265)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   7  (bases 1 to 3265)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   8  (bases 1 to 3265)
  AUTHORS   Aravin,A.A., Sachidanandam,R., Bourc'his,D., Schaefer,C., Pezic,D.,
            Toth,K.F., Bestor,T. and Hannon,G.J.
  TITLE     A piRNA pathway primed by individual transposons is linked to de
            novo DNA methylation in mice
  JOURNAL   Mol Cell 31 (6), 785-799 (2008)
   PUBMED   18922463
REFERENCE   9  (bases 1 to 3265)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Totoki,Y., Toyoda,A.,
            Ikawa,M., Asada,N., Kojima,K., Yamaguchi,Y., Ijiri,T.W., Hata,K.,
            Li,E., Matsuda,Y., Kimura,T., Okabe,M., Sakaki,Y., Sasaki,H. and
            Nakano,T.
  TITLE     DNA methylation of retrotransposon genes is regulated by Piwi
            family members MILI and MIWI2 in murine fetal testes
  JOURNAL   Genes Dev 22 (7), 908-917 (2008)
   PUBMED   18381894
REFERENCE   10 (bases 1 to 3265)
  AUTHORS   Carmell,M.A., Girard,A., van de Kant,H.J., Bourc'his,D.,
            Bestor,T.H., de Rooij,D.G. and Hannon,G.J.
  TITLE     MIWI2 is essential for spermatogenesis and repression of
            transposons in the mouse male germline
  JOURNAL   Dev Cell 12 (4), 503-514 (2007)
   PUBMED   17395546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_008765980.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.43905.1,
                                           SRR26643429.29219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000008.1  19861134-19861327   c
            195-258             JAXUCZ010000008.1  19860137-19860200   c
            259-390             JAXUCZ010000008.1  19857313-19857444   c
            391-605             JAXUCZ010000008.1  19854407-19854621   c
            606-727             JAXUCZ010000008.1  19849931-19850052   c
            728-808             JAXUCZ010000008.1  19848140-19848220   c
            809-1006            JAXUCZ010000008.1  19844447-19844644   c
            1007-1118           JAXUCZ010000008.1  19842929-19843040   c
            1119-1242           JAXUCZ010000008.1  19835733-19835856   c
            1243-1360           JAXUCZ010000008.1  19833845-19833962   c
            1361-1472           JAXUCZ010000008.1  19831229-19831340   c
            1473-1657           JAXUCZ010000008.1  19829442-19829626   c
            1658-1730           JAXUCZ010000008.1  19826182-19826254   c
            1731-1931           JAXUCZ010000008.1  19824687-19824887   c
            1932-2035           JAXUCZ010000008.1  19823626-19823729   c
            2036-2106           JAXUCZ010000008.1  19823388-19823458   c
            2107-2260           JAXUCZ010000008.1  19822130-19822283   c
            2261-2389           JAXUCZ010000008.1  19819948-19820076   c
            2390-2537           JAXUCZ010000008.1  19819279-19819426   c
            2538-3265           JAXUCZ010000008.1  19817985-19818712   c
FEATURES             Location/Qualifiers
     source          1..3265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..3265
                     /gene="Piwil4"
                     /note="piwi-like RNA-mediated gene silencing 4"
                     /db_xref="GeneID:689972"
                     /db_xref="RGD:1311015"
     exon            1..194
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2654
                     /gene="Piwil4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     piwi-like protein 4; piwi-like 4"
                     /codon_start=1
                     /product="piwi-like protein 4 isoform 1"
                     /protein_id="NP_001423492.1"
                     /db_xref="GeneID:689972"
                     /db_xref="RGD:1311015"
                     /translation="MSGRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRT
                     SVISQPHELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQ
                     LATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLS
                     EKLDHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIG
                     RNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLLFNADVNYKVLRNETVLEFMTDLC
                     LRTDMSCFTETCHKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDY
                     YKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMK
                     AVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKIL
                     LQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGST
                     GFSVGHPKIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCP
                     VPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDAL
                     SKDVAVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPAR
                     IIAYRDGVGNGQLKAVLEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESG
                     HTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRL
                     TFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL"
     misc_feature    108..167
                     /gene="Piwil4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4G033.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    900..1250
                     /gene="Piwil4"
                     /note="PAZ domain, Piwi_like subfamily. In multi-cellular
                     organisms, the Piwi protein appears to be essential for
                     the maintenance of germline stem cells. In the Drosophila
                     male germline, Piwi was shown to be involved in the
                     silencing of retrotransposons in the...; Region:
                     PAZ_piwi_like; cd02845"
                     /db_xref="CDD:239211"
     misc_feature    900..1250
                     /gene="Piwil4"
                     /note="PAZ domain, Piwi_like subfamily. In multi-cellular
                     organisms, the Piwi protein appears to be essential for
                     the maintenance of germline stem cells. In the Drosophila
                     male germline, Piwi was shown to be involved in the
                     silencing of retrotransposons in the...; Region:
                     PAZ_piwi_like; cd02845"
                     /db_xref="CDD:239211"
     misc_feature    order(1035..1037,1074..1076,1098..1100,1110..1112,
                     1164..1166,1209..1211,1215..1217)
                     /gene="Piwil4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239211"
     misc_feature    order(1035..1037,1074..1076,1098..1100,1110..1112,
                     1164..1166,1209..1211,1215..1217)
                     /gene="Piwil4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239211"
     misc_feature    1272..2600
                     /gene="Piwil4"
                     /note="PIWI domain, Piwi-like subfamily found in
                     eukaryotes. This domain is found in Piwi and closely
                     related proteins, where it is believed to perform a
                     crucial role in germline cells, via RNA silencing. RNA
                     silencing refers to a group of related...; Region:
                     Piwi_piwi-like_Euk; cd04658"
                     /db_xref="CDD:240016"
     misc_feature    1272..2600
                     /gene="Piwil4"
                     /note="PIWI domain, Piwi-like subfamily found in
                     eukaryotes. This domain is found in Piwi and closely
                     related proteins, where it is believed to perform a
                     crucial role in germline cells, via RNA silencing. RNA
                     silencing refers to a group of related...; Region:
                     Piwi_piwi-like_Euk; cd04658"
                     /db_xref="CDD:240016"
     misc_feature    order(1767..1769,1779..1781,1815..1826,1833..1835,
                     1863..1865,1872..1874,1884..1886,1896..1898)
                     /gene="Piwil4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240016"
     misc_feature    order(1767..1769,1779..1781,1815..1826,1833..1835,
                     1863..1865,1872..1874,1884..1886,1896..1898)
                     /gene="Piwil4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240016"
     misc_feature    order(1959..1961,1965..1967,2169..2171,2574..2576)
                     /gene="Piwil4"
                     /note="active site"
                     /db_xref="CDD:240016"
     misc_feature    order(1959..1961,1965..1967,2169..2171,2574..2576)
                     /gene="Piwil4"
                     /note="active site"
                     /db_xref="CDD:240016"
     exon            195..258
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            259..390
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..605
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..727
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            728..808
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1006
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1118
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1242
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1360
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1472
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1657
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1730
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1931
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2035
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2106
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2260
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2389
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2537
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..3265
                     /gene="Piwil4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccatactc ccaatctccg agtcacagcc tcaccctctc cctgcggaag aggaaatcct
       61 cctgtagagg tcctgcagcc ttggaaagcc gctgggaaac caggaacatg agtggacggg
      121 cccgtgtgag ggcgcgaggc atcaccactg gccacagtgc cagggaagtg gagcgggccc
      181 caagagacct catggtcaca tctgtcagtc ccggggacaa cgaggccagc agtaggacaa
      241 gcgtcatttc acagccacat gagcttggcg tctcttctgg tgatggtaga cgtactctcg
      301 tggaaaaaag aggcaatggc agacaggact tcgtcgattt gggtgtctgt accagggaga
      361 agttgactca cgtaaaagat tctaaaacag gttctagcgg aatacctgtg cagctggcta
      421 caaatctctt ccatttagat ttgccccagg attggcagct ataccagtac catgtcacat
      481 acagcccgga tttagcctct aggaggctga ggactgctct gctgtataac cacagcatac
      541 tctccgacaa ggcaaaggca ttcgacggca ccagcctttt cctctcagaa aagctggacc
      601 acaaagtcac agaactgaca agtgaaaccc aaagagggga gactgtgaag ataactctca
      661 ccctgaccag tgagctgttc ccaaactccc cgatgtgcat tcagtttttc aatgtcatct
      721 tcagaaagat ctttaaaaag ttgagcatgt accagattgg acggaactac tataagcctt
      781 cagagccagt ggagatcccc cagtacaaat tgtccctgtg gcctgggttt gccatttctg
      841 tgtctcgctt tgaaagcaaa ctcctgttca atgctgacgt aaactataaa gtcctccgca
      901 atgagactgt tctggaattc atgactgatc tctgcctcag aaccgacatg tcatgcttca
      961 ctgagacgtg ccacaaacag ctagtggggc tcattgtcct taccaggtac aacaacaaaa
     1021 catatcgtat cgatgacatt gactggtctg tgaagcccac acatgccttt cagaagcggg
     1081 atggctcaga gaccacgtat gtggattact acaagcagca atatgatatc accttatctg
     1141 acctaaatca gccagtgctt gtcagtctgt tgaaaagaag gagaaatgat aactccgagc
     1201 ctcagatggt ccacctgatc ccggagctct gctttctcac gggcctgacc agccaagcaa
     1261 cctcagactt ccgcttgatg aaggcagtcg ctgaagaaac tcggctcagt cctatgggaa
     1321 ggcagcagca actagcccga ctggcagatg acatccagag aaaccaagtg actcggtttg
     1381 agcttgagac ctggggattg cattttggaa gccagctatc cctgaccggc cgggttgttc
     1441 cctctgaaaa gatcctgctg caggaccaca catgtcaacc tgcatttgct gctgattggt
     1501 ccaaagatat gcgatcttgc aaggttctga gttctgagcc tttgaataca tggttgatcg
     1561 tgtgctgtag cagggctgag catttgattg aatccttcct gagctgtctg aggagagttg
     1621 gaggttccac gggattcagt gtgggccacc caaaaatcat aaaagtggat gaaaaccctg
     1681 cagcgttcct tcgagccatc cagctgcacg tcaaccccga tgttcagttg gtgatgtgca
     1741 tcctgccttc taatcagaag aactattacg actccattaa aagatatttg agctccgact
     1801 gcccggtccc aagccagtgt gtgctgaccc ggaccttgaa caaacaggga atgatgctga
     1861 gtgtggccac caagatcgcc atgcaaatga cctgcaaact cgggggcgag ctgtgggctg
     1921 tggagatccc attgaagtca ctgatggtcg tgggcatcga catctgtaga gacgccctca
     1981 gcaaggatgt agcggtcgtc gggtttgtcg ccagcattaa ctccaggatc accaggtggt
     2041 tttcccgctg tgtcctccag agaacggcag ctgatattgc agattgcctg aaagtctgca
     2101 tgactggtgc tctcaacaag tggtacaaac acaaccacga tttgccggca cggataatcg
     2161 cgtaccggga tggtgtgggc aacggccagc taaaggcagt tttggaatac gaagtcccac
     2221 agctgctgag cagtgtgaca gaatgtggct ccgacgccag gagctgtaga ctgtcagtgg
     2281 tcgtggtcag gaagaggtgt ctgctgcgtc tctttgccga gtctggccat acgctacaga
     2341 accccccact tggcactgtc gtggactcag aagcaacacg tccagagtgg tatgacttct
     2401 acctgaccag ccagactgct aaccggggga ctgttagtcc cacctactac aatgtcatct
     2461 atgacgacaa cgctctgaag cctgaccata tgcagcggct gaccttcaaa ctgtgccacc
     2521 tctactacaa ctggcagggc gtaatcagtg tccctgctcc gtgccagtat gcacacaagc
     2581 tgaccttcct ggtggcacaa agcatccaca aggaaccaag tctggaatta gccaataagc
     2641 tcttctacct gtgacaagtg ggccaatagc atggctcgat ggagacgcca aaaagcggtt
     2701 gctatgcttt gttcaaatct gcctaatgct caaggctcct gctgcttaaa ggagcttcag
     2761 cctgatttta agtattggga aggagagggt tttttggttt ttgttttttt gttttgtttt
     2821 gttttgtttt ttgttttctg ggtttttttt ttgttgttgt tgttgttgtt tttaaagtca
     2881 tctgaatcag ttgaggacaa acctatgggg atttttgtct cccctgtgtc taaaaacaac
     2941 aatgacaaac aaacaaaaac ccacagagtg atgggttttc ttgtggctct gtcaggcgac
     3001 attttacttt gtcctggttt atcctcgtat tttttttttt ttaagtaaat gcttgaggtg
     3061 aattctcaca tggtatatac gtgatgatat tgggatatat catcacagct aactggattc
     3121 taaaacaata ttcgtgtggt attgtgatgg tgtttaagag gggtttaact tctttcctga
     3181 cattaccagg gttgttctaa gtatcgtaga gcattttgta gagtgggtta agtaaatact
     3241 gaaaataaag actccctgag catcg
//
LOCUS       NM_001436546            3871 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus zinc finger protein 202 (Zfp202), transcript
            variant 2, mRNA.
ACCESSION   NM_001436546 XM_063265964
VERSION     NM_001436546.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Wagner,S., Hess,M.A., Ormonde-Hanson,P., Malandro,J., Hu,H.,
            Chen,M., Kehrer,R., Frodsham,M., Schumacher,C., Beluch,M.,
            Honer,C., Skolnick,M., Ballinger,D. and Bowen,B.R.
  TITLE     A broad role for the zinc finger protein ZNF202 in human lipid
            metabolism
  JOURNAL   J Biol Chem 275 (21), 15685-15690 (2000)
   PUBMED   10748193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_063265964.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.44722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000008.1  49439867-49439976
            111-253             JAXUCZ010000008.1  49447840-49447982
            254-340             JAXUCZ010000008.1  49448823-49448909
            341-842             JAXUCZ010000008.1  49454165-49454666
            843-1053            JAXUCZ010000008.1  49455265-49455475
            1054-1142           JAXUCZ010000008.1  49455771-49455859
            1143-1272           JAXUCZ010000008.1  49456674-49456803
            1273-1392           JAXUCZ010000008.1  49457345-49457464
            1393-3871           JAXUCZ010000008.1  49457801-49460279
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3871
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="zinc finger protein 202"
                     /db_xref="GeneID:500981"
                     /db_xref="RGD:1562294"
     exon            1..110
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            111..253
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            254..340
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            341..842
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    396..398
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="upstream in-frame stop codon"
     CDS             435..2366
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /codon_start=1
                     /product="zinc finger protein 202"
                     /protein_id="NP_001423475.1"
                     /db_xref="GeneID:500981"
                     /db_xref="RGD:1562294"
                     /translation="MATALELEDQDLWEEEEEGVLMVKLEDDFTCGPESALQGDDPVL
                     ETSHQNFRCFRYQEASSPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPG
                     ELQSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVQGQEVLSEETLHLGVEPES
                     SNEQQEPTQTLTAEQPHEEALRSTDLGTLEQESLQHEGERLPLLESEVPVSQHADLPT
                     EQGSGHPEMVALLTALSQGLVTFKDVALCFSQDQWSDLDPTQKEFYGEYVLEEDCGIV
                     VSLSFPIPRLDDPSQIREEEPQVPGVHESQEPAEPEILSFTYTGDMSEAEEECVEQQD
                     TNKSILANTEIHQTPDWEIVIEDNTSRLNERFGTNVSKVNSFTNIRKTMPVHSQSGRQ
                     HHCPLCAKSFTCNSHLIRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKVNTPHK
                     HPPNRKTVDASQVQSEATTRVEKPYTCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTIC
                     GKSFSQKSVLTTHQRIHVGGKPYTCANCGENFSEQKQYLAHRKTHVSEENHLCSECGR
                     SFNHSAAFAKHLKGHASVRNCRCDECGKSFSRRDHLVRHQRTHTGEKPFTCATCGKSF
                     SRGYHLIRHQRIHTGKTKT"
     misc_feature    567..899
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    567..899
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    1149..1331
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    1149..1331
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    <1434..2312
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <1434..2312
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1617..1679
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1617..1679
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1632..1634,1638..1640,1644..1646,1650..1655,
                     1662..1667,1674..1676,1716..1718,1722..1724,1734..1739,
                     1746..1751,1758..1760,1878..1880,1884..1886,1890..1892,
                     1896..1901,1908..1913,1920..1922)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1632..1634,1638..1640,1644..1646,1650..1655,
                     1662..1667,1674..1676,1716..1718,1722..1724,1734..1739,
                     1746..1751,1758..1760,1878..1880,1884..1886,1890..1892,
                     1896..1901,1908..1913,1920..1922)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1701..1763
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1701..1763
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1863..1925
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1863..1925
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1947..2009
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1947..2009
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2031..2093
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2031..2093
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2115..2177
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2115..2177
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2130..2132,2136..2138,2142..2144,2148..2153,
                     2160..2165,2172..2174,2214..2216,2220..2222,2232..2237,
                     2244..2249,2256..2258,2298..2300,2304..2306,2310..2312,
                     2316..2321,2328..2333,2340..2342)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2130..2132,2136..2138,2142..2144,2148..2153,
                     2160..2165,2172..2174,2214..2216,2220..2222,2232..2237,
                     2244..2249,2256..2258,2298..2300,2304..2306,2310..2312,
                     2316..2321,2328..2333,2340..2342)
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2199..2261
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2199..2261
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2283..2345
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2283..2345
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            843..1053
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1142
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1272
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1392
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..3871
                     /gene="Zfp202"
                     /gene_synonym="RGD1562294"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttccgac ccgctgggcc ccgcgcgact cggatcccgc tccgctcttt tggccgggag
       61 tgggtggggg agcaccgggc aggggaggag ccgctggagc cgcgggagac gaatctgaat
      121 aaatggctcg tcacccttaa ataaagtgct gatgacatac caaaaagaaa tgattccatc
      181 catgatctgg tgaatttatt aagactatgt acaagaacat gagtgaatct aaggcattta
      241 tatcacagaa aaggacacca gagaaagata atggaattgg aaggccaaca atttgcaagg
      301 catcatgcat gtaacctcac acatcccatg aaatgtagag gtcccttagg aggaacccct
      361 tgaggtaccc ggtctagaat acattaatgc ccttgtgagt gctaaatggt gtgataacac
      421 ccaagagcca ggaaatggcg acagccttgg agctagagga ccaagatctt tgggaagaag
      481 aagaagaagg agttctgatg gtgaaactgg aggatgattt cacctgcggg ccagaatctg
      541 ccttgcaggg cgatgatcct gtactggaga cctctcacca gaatttccga tgctttcgct
      601 accaggaagc atctagccct cgagaagccc tcatcagact tcgagagctt tgtcatcaat
      661 ggttgaggcc agagaggaga acaaaggagc agatccttga gctgcttgtg ctagaacagt
      721 tcctcactgt cctacctgga gaactgcaga gctgggtgcg aggccaacgg ccagagagtg
      781 gcgaggaggc agtgacgctg gtggagggtt tgcagaaaca acccaggaga ccaaggcggt
      841 gggtaaccgt ccatgttcaa ggccaggaag ttctgtcaga ggagacacta cacctagggg
      901 tggagccaga gtcctccaat gagcagcaag agccaacaca gaccttgacc gctgagcagc
      961 cccatgagga agccctccga agcacagatc tggggacact ggaacaggag agcttgcagc
     1021 atgaagggga gcgcctgccc ctgctggaaa gtgaggttcc agtgtcccag catgcagacc
     1081 ttcccacaga acaagggtct ggacacccag agatggttgc tcttctcact gctctctctc
     1141 agggactggt cacattcaag gatgtggctc tgtgcttctc acaagatcaa tggagtgatc
     1201 tggatccaac acaaaaagaa ttctatggag aatatgtctt ggaagaagat tgtggaattg
     1261 tggtctctct gtcatttcca attcccagac tagatgatcc ctcccagatt agagaagaag
     1321 agcctcaggt cccaggagtc catgaatctc aagaacctgc agaaccagaa atcctgagtt
     1381 ttacctatac aggagacatg agtgaagccg aggaagaatg tgttgagcaa caagatacaa
     1441 acaagtctat tttggcaaac acagaaattc accagactcc agattgggaa atagtcattg
     1501 aggataatac cagtagactt aatgaaagat ttggtacaaa tgtttctaaa gtcaatagct
     1561 tcacaaatat taggaaaact atgcctgtcc actcccagtc agggagacag catcattgcc
     1621 ctctatgtgc aaaaagcttc acatgtaatt ctcatcttat taggcactta agaactcaca
     1681 caggagaaaa accctataaa tgtatggagt gtgggaaaag ttacacacgg agttcacatc
     1741 tagcgaggca ccagaaagtc cataaggtga acactcctca taaacatcct ccaaaccgga
     1801 agactgtgga tgcctctcaa gtccagtctg aggcaactac ccgtgtggag aaaccatata
     1861 cctgtgatga ttgtggaaag cacttccgtt ggacatcgga cctggtcagg caccagagga
     1921 cacatacagg agaaaaacct tttttctgca ctatttgtgg caaaagcttc agccagaaat
     1981 ctgtgttaac aacacaccaa agaatccatg ttggaggcaa gccctacaca tgtgcgaact
     2041 gtggagaaaa cttcagtgag cagaaacagt atctggcaca ccggaagaca catgtgtctg
     2101 aggagaacca tctctgcagt gagtgtgggc gctccttcaa ccatagtgct gcgtttgcca
     2161 agcacctgaa aggccacgct tcagtgagga actgccggtg tgatgaatgt ggtaaaagct
     2221 ttagcaggag ggatcacctt gtcagacatc aacgaacaca cactggggaa aagcctttta
     2281 cctgtgctac ctgtggaaaa agtttcagca gaggatatca cttaatccgc catcagagaa
     2341 tccacacagg aaagaccaag acctagctag gggccatatg tggagagctt aattcagcag
     2401 caaactgaga tgggatgggt tctgtgctca acctgagaag aacttttgta aggcgtctct
     2461 ttgatctgcc cataccttat gtcacctctt ctaactacca aacaaaagcc ccatccagaa
     2521 ctactcaact tttctcagtt gaggcttctg tttcactggc atgctcctgc ctctgcctca
     2581 tgggtgtgat ctaggagata tgggacttaa ggaaatttgg gtcattatat tttgagaaac
     2641 gtaggctgct ctagatcctg gagactactt aacagcctca acttcagtgt ggtcaaggat
     2701 aaggacctag gtctgataaa caaccaacct taaagggtct gtccttactg ggctcaaacc
     2761 ttaaggcacg cagccctaaa ctcaagatag gaggtttggg tgctgataga tttgccacac
     2821 actgacggga tagctacaga ttcctcacta actcgcctct tcactgtaca ctttccttca
     2881 atgctggaga caaaggggaa gagttttgaa ggacaaatcc ttaaggctcc tccacaagga
     2941 ttttgacagg ctgctccttt ccccattgtc agaatgacac taagtgccac acactgctac
     3001 aaaagcgggc ctaatcaaaa gcctcttggg gtgcaccaca cctgtctaca tactcctgtc
     3061 tttagctttt ctactattca gccactgtca gtttgtccct tacatgccta ctgcaaaaga
     3121 gatgtagtcc tggagtgctg aagaattcag taaagcataa ttaagacatg gtgaaatcca
     3181 ttacattccc acataatgtt taagcgtgtc ctttatttgg cttgtaagaa gggatctgaa
     3241 gctcttgtta gcgtagaaag gcactgtatc cagtgcagaa tcctaattga ctgaggaaaa
     3301 ctagagaaga tataaaacac tttggaagac tatgaaacag ttgttgccac tggccaagac
     3361 tgttaggact gttctgacac ctagtccttg gtatgcctgc ctcggttttt taatgtctgg
     3421 gaagattatg aaccctagta cttgggaccc tgagaattaa tcggaagtaa agggattttt
     3481 atgcgtctgt gttacttggt ttttaatgtg taagtgtttt catgtaattg tgaactgaaa
     3541 agtagtatct cctggtggcc tatgggtctt ttgcctgttc aaagttccca ggaggctgaa
     3601 attttatgaa ccttacatgt ctggtcatct gaaaaggact gaggacagat acttgataga
     3661 cagagcccag gatgtgggat taaagaatgg gaaggcagat acacttctat gcctgatttc
     3721 ttctgcttat ttcacaatca cagaggaata tggtgagtta gcaagtcatc ttcccagctc
     3781 taatatccca atagggaatc ctctcatgat gaagccagtc aatcgttgtc atgaagatac
     3841 ataaataaat aaagtgatac ttacagccaa a
//
LOCUS       NM_001436558            3707 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus galactosidase, beta 1-like 2 (Glb1l2), transcript
            variant 1, mRNA.
ACCESSION   NM_001436558 XM_006242738
VERSION     NM_001436558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3707)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006242738.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.31062.1,
                                           SRR26360172.2334858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000008.1  33442384-33442511   c
            129-326             JAXUCZ010000008.1  33432033-33432230   c
            327-395             JAXUCZ010000008.1  33430296-33430364   c
            396-491             JAXUCZ010000008.1  33429601-33429696   c
            492-600             JAXUCZ010000008.1  33427276-33427384   c
            601-693             JAXUCZ010000008.1  33415421-33415513   c
            694-775             JAXUCZ010000008.1  33412669-33412750   c
            776-846             JAXUCZ010000008.1  33402492-33402562   c
            847-931             JAXUCZ010000008.1  33400046-33400130   c
            932-1069            JAXUCZ010000008.1  33398755-33398892   c
            1070-1150           JAXUCZ010000008.1  33398103-33398183   c
            1151-1257           JAXUCZ010000008.1  33397502-33397608   c
            1258-1398           JAXUCZ010000008.1  33396800-33396940   c
            1399-1470           JAXUCZ010000008.1  33396496-33396567   c
            1471-1549           JAXUCZ010000008.1  33396178-33396256   c
            1550-1637           JAXUCZ010000008.1  33395117-33395204   c
            1638-1749           JAXUCZ010000008.1  33394725-33394836   c
            1750-1866           JAXUCZ010000008.1  33394238-33394354   c
            1867-3707           JAXUCZ010000008.1  33392106-33393946   c
FEATURES             Location/Qualifiers
     source          1..3707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3707
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="galactosidase, beta 1-like 2"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
     exon            1..128
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1953
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /EC_number="3.2.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-galactosidase-1-like protein 2"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein 2 isoform 1"
                     /protein_id="NP_001423487.1"
                     /db_xref="GeneID:503194"
                     /db_xref="RGD:1564436"
                     /translation="MPKWSLRRRPGRTLGLLLLLVLSFLVLRRLNWTSVLPLWLQRQR
                     LGLRTKGPNFMLEDSTFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLH
                     EPERGKFDFSGNLDLEAFIWLAAKIGLWVILRPGPYICSEIDLGGLPSWLLQDPDMKL
                     RTTYPGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNGDHAYMPYIKKA
                     LEDRGIIEMLLTSDNKDGLEKGVVDGVLATINLQSQQELVALNSILLSIQGIQPKMVM
                     EYWTGWFDSWGGSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFGD
                     YKADVTSYDYDAILTEAGDYTAKYTKLRELFGTFSGVPPPPPPELTAKMVYEPVTPSF
                     YLSLWDALLYMDKPITSEIPINMENLPVNNGNGQAFGYVLYETTIFSSGVLSGLVRDR
                     GQVFLNRVSIGFLDYTTTKITIPLTQGYTILRILVENRGRVNYGNNIDSQRKGLIGNL
                     YLNNKPLKNFKIYSLDMTKQFFQRFDMDKWSVVPKEITFPAFFLGTLSVGIYPSDTFL
                     KLEGWVKGVVLVNDHNLGRYWNVGPQETLYLPGVWLDKGLNKVIIFEETMAGSMVQST
                     DIPHLGRNQYVN"
     misc_feature    199..1140
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     misc_feature    199..1140
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /note="Glycosyl hydrolases family 35; Region:
                     Glyco_hydro_35; pfam01301"
                     /db_xref="CDD:396048"
     exon            129..326
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            327..395
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            396..491
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            492..600
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            601..693
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            694..775
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            776..846
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            847..931
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1069
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1150
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1257
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1398
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1470
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1549
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1637
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1749
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1866
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..3707
                     /gene="Glb1l2"
                     /gene_synonym="RGD1564436"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggagtag gaaccccggt gtctaccagc ggctttcgcg cgatgcccaa gtggagcctg
       61 cggcggaggc cgggccgcac actcggactc ctgctgctgc tggtcttgag cttcctggtg
      121 ctccgcaggt tgaactggac ctctgtgctt cccctatggc tccaacgtca gcgcctggga
      181 cttcgaacaa aaggcccaaa cttcatgctg gaggactcca cctttcagat tttgggggga
      241 tccatacact atttccgtgt gcccagggaa tactggaggg accgcctgct caaactgaaa
      301 gcctgtggct tgaataccct tactacctat gtgccatgga acctccatga gccagaacga
      361 ggcaaattcg acttctctgg gaatctggac ctagaggcct ttatctggct ggctgcaaag
      421 attggcctgt gggtgattct gcgaccaggg ccctacatct gtagtgagat tgacctcggg
      481 ggcttgccca gctggctcct tcaagaccct gacatgaagc taagaacaac ttaccctggc
      541 ttcactaagg cagtggatct ttactttgac cacctgatgt ccagggtggt gccgcttcag
      601 tataagcatg gggggcctat cattgcggtg caagtggaga atgagtacgg ttcctataac
      661 ggagaccatg cgtacatgcc ttacatcaag aaggcactgg aagaccgtgg catcattgag
      721 atgctcctga cctcagacaa caaagatggc ctggaaaagg gagtggttga cggagtgctg
      781 gccaccatca acttacagtc acaacaggag ctggtggcac taaacagtat tctcttatct
      841 atacagggga ttcaacccaa gatggtgatg gagtactgga cagggtggtt tgactcgtgg
      901 ggtggctccc acaacatctt ggattcctct gaggtcctgc aaacagtgtc tgccatcatc
      961 aaagacggct cctccatcaa cctgtacatg ttccatggag gcacaaattt tggcttcata
     1021 aatggagcca tgcattttgg tgactacaag gctgatgtta ccagctatga ctacgatgct
     1081 atattgacag aggctggaga ttacactgcc aaatacacca agcttcgaga actctttgga
     1141 accttctcag gcgtccctcc acctcctcca cctgagctta ctgctaagat ggtctatgag
     1201 ccagtgactc catctttcta cctgtcactg tgggacgctc tcctgtacat ggataagcca
     1261 atcacatctg agatacccat caacatggag aacctgccgg taaacaatgg taatgggcag
     1321 gcctttgggt atgtcctcta tgagaccacc atcttttcat ctggcgtcct cagtggcctt
     1381 gtgcgtgaca gaggacaggt ctttttgaac agagtgtcca taggattctt ggactatacg
     1441 acaacgaaga tcactatccc cttgacccag ggttacacaa tactgaggat cttggtggag
     1501 aatcgtgggc gagtcaacta cggaaataac attgacagcc agcgcaaagg tttaattgga
     1561 aatctctatc tgaataataa acccctgaaa aacttcaaaa tctacagcct ggatatgaca
     1621 aagcagttct ttcagaggtt cgacatggac aagtggagtg tcgtacccaa agaaattacc
     1681 tttcccgctt tcttcctggg caccttgtca gttggcattt acccttctga cacatttctg
     1741 aagttggagg gctgggtgaa gggggttgtg ctcgtcaatg atcacaacct tggacgctac
     1801 tggaatgtag gacctcagga gactctctac ctccccggtg tctggctgga caaaggactc
     1861 aacaaggtta tcattttcga agagacaatg gcaggctcca tggtacagtc tactgatatc
     1921 ccccacctgg gcaggaacca gtatgttaac tgaacagcag cccctgcagc ccctgctatg
     1981 gctggcagct tccttccttc ctgtcctgca ggagaagtca tcgtaactag caacctcagg
     2041 gaatgaaggg ctatattcaa ctcaggccaa aattctatgc ctaagcctaa gagaagatgg
     2101 ggtagcgctg tctgggatac actcagagtg agatgtcttc tcttctggtt ttgtggacgg
     2161 gcattttctg ctcccctgat cttccagggg aggccacaga gcggccacag agtatgtagt
     2221 tagttatatc accttcaaag aaggtgctga ggcgggtggg cactgccctc ttctggaagt
     2281 gaaagcctca ctggccagcc tgctggttct aggtaggctt tttgaacatt cccagcaggg
     2341 tgtggtcaca ccctagacag cttctttgtg ctcctgaatt tgtgggtttg tcattgtttg
     2401 tagagccaag agaaaagggg tcttatttga gtcaacttta tttttttgac tttgcacctg
     2461 ccagttctgg ggatctggaa gaagtctttt cctgttctct ctgtctctta ttacattaat
     2521 cagttgataa actgagccta agagaaacag gcatgttcaa tccagcatgt tagagctggg
     2581 cacttcagca gaaaccacct cacatccatg ctctcaggaa gggaatggca gaagacccag
     2641 cgaggtggtg ctgggcagct atgcccgact gcagtagaat ctggggttag ctagagcaca
     2701 caggtctagc accgtccttg ttttcagctc agctggtttc tttgaacact cgtcttcccc
     2761 ttcctgacca aacagcaggg aggaggaaag gcagccttct gtcacacaca gtccagactg
     2821 aaggctcttg ttcaaggaat caagtgcaat ggcttggtgt ggtcttgcca ttctaaactg
     2881 caatacactt gaagcaaacc ttctttgtgg ggtctccagc ttctctgtac cattctcagc
     2941 catggcagaa agtgaccttt agggatccag atactgatgg tacccagctg gcaggtggca
     3001 catgccactg gcttcttacc acctttcctg attttccttc tccttgaaat gtcattgcac
     3061 taagagcagt ccaatctcat gctggtggtt aagagtaaga actttctaga aagctaaacc
     3121 acaatatata agttagctat aggggatagt ttttcttcat aaattacatc tgacatgtac
     3181 tgctccaagc cgattgtctt cagtaatagt gaaaatcaaa taacacacat ccgtgagcat
     3241 agtgcccaca cagaagccta gcgaagatgg gttaggcaag agcaggcaaa cagagagcct
     3301 tgcagactga caggccagct tcctgagtat gaccagggac actgtagtca gggctactgc
     3361 agccaccgag ctaagctccc agctaatgta tccgcaagtg gtcatagcgg aacagcccat
     3421 gtcccactgg gtctgcgaaa tcgaggtttt ctgtctgtct gtctatctgt ccatctctct
     3481 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctca
     3541 tattctctca gatggggtca tattatgtag ccccgccttg atcttttgtt tctcttgcct
     3601 tagccttgca acttctctac catcatgccc aactcaaagg aagctttttt tttttaaagc
     3661 cctttatttg tcttaaagtt ttaaaataaa attatgtgat aagtttc
//
LOCUS       NM_001436552            3393 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus layilin (Layn), transcript variant 1, mRNA.
ACCESSION   NM_001436552 XM_006243049
VERSION     NM_001436552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Bono,P., Rubin,K., Higgins,J.M. and Hynes,R.O.
  TITLE     Layilin, a novel integral membrane protein, is a hyaluronan
            receptor
  JOURNAL   Mol Biol Cell 12 (4), 891-900 (2001)
   PUBMED   11294894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006243049.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.721013.1,
                                           SRR21887620.721014.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840108,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000008.1  60280533-60280738   c
            207-504             JAXUCZ010000008.1  60277553-60277850   c
            505-662             JAXUCZ010000008.1  60271374-60271531   c
            663-698             JAXUCZ010000008.1  60267495-60267530   c
            699-770             JAXUCZ010000008.1  60266449-60266520   c
            771-870             JAXUCZ010000008.1  60265595-60265694   c
            871-3393            JAXUCZ010000008.1  60261325-60263847   c
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3393
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="layilin"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
     exon            1..206
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="upstream in-frame stop codon"
     CDS             122..1231
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="layilin isoform 1 precursor"
                     /protein_id="NP_001423481.1"
                     /db_xref="GeneID:500996"
                     /db_xref="RGD:1564444"
                     /translation="MQPGAALQAMLLAVLLAKPRDSKGHLLSGQRFCWEGTRRPCYRV
                     IYFHDTSQRRNFEEAKEACMKDGGQLASIETADEQRLIENFIESLQASDGDFWIGLKR
                     LEEKQHNSTACQDLYAWTDGSLSQFRNWYMDEPSCESEVCVVMYHQPSAPPGIGGPYM
                     FQWNDDRCNTKKNFICKYSDDKPSTTPSLSPGGEATEPAAPILPEETLEIDTKERREA
                     ALNLAYILIPSIPLFLLLVVTSAVCWVWICRRKREQTDPPTKEQHTIWPTPHQENSPD
                     LEVYNVIRKQSEADLAEPRPDLKNISFRVCSGEAMPDDTSCDYDNMVINPSESGLVTL
                     ASMEGRFVTNDIYEFSPDRMGRSKESGWVENEIYY"
     sig_peptide     122..193
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    209..655
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; Region: CLECT; cl02432"
                     /db_xref="CDD:470576"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     misc_feature    order(539..541,551..553,557..559,605..607,611..622,
                     629..637)
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153065"
     exon            207..504
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            505..662
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            663..698
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            699..770
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            771..870
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
     exon            871..3393
                     /gene="Layn"
                     /gene_synonym="RGD1564444"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcggggt ctggatcctt gggagatgca gcttccttgg ttgcagttgt ccaaagcagt
       61 cgccgacttg cccacttctc tgccttagtc ccggagtgtc aggaggcact ggagtccagc
      121 tatgcaaccc ggagcagcgc tgcaggccat gttgctggcg gtgctgctgg ccaaaccgag
      181 ggattcgaag ggtcacctgc tgagcgggca gcggttctgc tgggaaggga cacggaggcc
      241 ttgctacaga gtcatttatt tccatgacac ctctcaaaga cggaactttg aggaagcgaa
      301 agaagcctgc atgaaggatg gaggacagct agccagcata gaaacggcag atgagcagag
      361 gctgatagag aacttcattg aaagcctcca ggcatctgat ggtgatttct ggattggcct
      421 caagaggttg gaggagaaac agcacaacag cacagcctgc caggaccttt acgcttggac
      481 agatggaagc ctgtcacagt tcaggaactg gtatatggat gagccttcct gtgagagcga
      541 ggtctgcgtg gtcatgtacc atcagccatc agcacctccg ggcatcgggg gcccatatat
      601 gttccagtgg aatgacgacc ggtgcaacac gaagaagaat ttcatttgca aatattctga
      661 cgataaacca agtacaacac cctctcttag tcctggaggt gaagcaactg agccagcagc
      721 acccatactt ccagaagaaa ctctggaaat agacaccaaa gaacgcagag aggctgcttt
      781 gaatcttgcc tacatcctaa ttcccagtat tccccttttc ctcctacttg tggtcacttc
      841 agctgtgtgt tgggtttgga tctgtagaag aaaacgggaa cagacagacc ctcccacaaa
      901 ggagcagcac accatttggc ccactcctca ccaagagaac agccctgacc tagaagttta
      961 caatgtcatc agaaaacaaa gtgaagctga tttagccgag ccccggccag atctgaagaa
     1021 catctccttc cgggtgtgtt ctggggaagc catgcccgat gacacgtctt gtgactatga
     1081 caacatggtt ataaaccctt ctgaaagtgg gttagtgact ttggcaagta tggagggtag
     1141 atttgtgacc aatgacatct atgaattctc ccccgacaga atggggagga gcaaggagag
     1201 tggatgggta gaaaatgaaa tatattacta agacatatga aaaaaccagc aagaatgtaa
     1261 aaagagaagg aaaagcctcc aatgtcttac aaagacgata ttcagaaggc ttatgagaag
     1321 gttcagctca ggtcttaggg gcaagcacag catcacaagt tccttctggg tccccaagtt
     1381 ctggctgcac tccctatcca ggaacctcgt ccagctcagc ctggtccaag gcacctcacc
     1441 caaggggctg ctgcacagca gaccctcaga gaaagccagt ggcttccaac tgacgctcaa
     1501 gagctggtgc tttccctggt caggattaag gtgtgaccag ggagcttgga aagcctacct
     1561 ctaggctctg ttttccttgc tctgtacatc tgtgcaggca atcacaaaga cacaaatggt
     1621 gggatcctct caaagcctct gtatggaagc cccaggctgg cctgcacatc aacaattccc
     1681 aacctgcatc ccacccccac ccctgaaaaa aaaagtcaat aaaaagcagg aagcagaatg
     1741 ttagtcagtc tgtgtctaca gcccttcctc tgcatgtggc ctcaggggag tttttttttt
     1801 ttttttcatt ctcccaacat ctaaacttgg aaaagtccaa cttggaaata ctttcgaaag
     1861 taaaaatgag ctctgtttgc ttcagagctt cttcttctct gggctcagac agtatgtgct
     1921 gttctgggga tgggtggcag cagcatagga aactgactgt atacaggact ggtgaaaaga
     1981 gtcgacctag taaggaaaag gagaggcagg cttctcacta tcagagaagg cagccacggt
     2041 caccagaagg gaggaaactg gaacaggtcc tgttgtgtgc aaggggaatc gaaacagtgc
     2101 tgccgtcatt gtggaatttt atgtactgag tatacatata tatgtatgtt tatatgtgta
     2161 tgtatatgtg tgttttccat taaataagcc agtactccat gaaactggat gactcaagga
     2221 cagaagcaga agaaatatga gttacttaag taatgaaaag gaaataatgg gtatctaaac
     2281 atagatagaa ttaacaggtt tattgttcta caggaacaat gaggacccgg atatcacaat
     2341 gacctataac gtatttatga ataactatga gaaaggagct caagggcagc aaacacaaag
     2401 tcatgataaa aatatattta ttgccttggt tgactagtac acattgtata tttgtactgt
     2461 taagtaatac cattgttaaa acttaaagag attgggaatg agaatgttca tttgggaaat
     2521 tttacaccac caccaagcaa gactgattaa gaatcagcag atagggttgg ggatttagct
     2581 cagtggtaga gtgcttgcct agcaggcgca aggccctggg tttggtcccc agctccggaa
     2641 aaaaaaaaaa aagagagaga gagagagaaa aaaaaaagaa tcagcagatc acagacacca
     2701 actcgtaatg atccaccttt ggtaatgagg attaatttga atattaaatc attgaaagta
     2761 aaaccaacaa agagaatgtg actcaatggg taaagtggga aaacatgggc atatgctgat
     2821 acaaaataaa agaataaatt aaaactttga tgtagatggt atatttacat gatttcaggt
     2881 aaagatcatt gattgcaaaa gtgacccaac aggcaaagcc acctcagtca cctgatgaat
     2941 gtgaattctg tggacgacga agtgtactga gattgtagac ctcacactgt ggtgtggtga
     3001 gagggacatg gcatcacatc cacgctgtct cacagtgtac aagctgatca taaggaggcc
     3061 ttgcataaca acaatttgat ggacaatcta caaactacct ggacggcaaa cctgaactct
     3121 gatggtaaag acggtggaag cgagacaggg gcagctgcaa taggaggaca gtaaggtgat
     3181 ggctccaagc gtgaccagat cctgaaatgg atcccttttc tcctgtaaag gagaagatgg
     3241 gaacaaatgt ggatgacgtc tgaggactaa atgtcaaaaa cgtgcagtgc taacttccta
     3301 acttttgcgt tgccctgagg acatggcctc ttggcactgg gaatgtcttc ccagaaagca
     3361 cacagtgaag taataaagga caatggacta tca
//
LOCUS       NM_001436529            2060 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus melanocortin 2 receptor accessory protein 2
            (Mrap2), transcript variant 1, mRNA.
ACCESSION   NM_001436529 XM_006243488
VERSION     NM_001436529.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Asai,M., Ramachandrappa,S., Joachim,M., Shen,Y., Zhang,R.,
            Nuthalapati,N., Ramanathan,V., Strochlic,D.E., Ferket,P.,
            Linhart,K., Ho,C., Novoselova,T.V., Garg,S., Ridderstrale,M.,
            Marcus,C., Hirschhorn,J.N., Keogh,J.M., O'Rahilly,S., Chan,L.F.,
            Clark,A.J., Farooqi,I.S. and Majzoub,J.A.
  TITLE     Loss of function of the melanocortin 2 receptor accessory protein 2
            is associated with mammalian obesity
  JOURNAL   Science 341 (6143), 275-278 (2013)
   PUBMED   23869016
  REMARK    Erratum:[Science. 2013 Aug 30;341(6149):959]
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Sebag,J.A. and Hinkle,P.M.
  TITLE     Regulation of G protein-coupled receptor signaling: specific
            dominant-negative effects of melanocortin 2 receptor accessory
            protein 2
  JOURNAL   Sci Signal 3 (116), ra28 (2010)
   PUBMED   20371771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006243488.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.912894.1,
                                           SRR26360176.1861836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000008.1  96988079-96988151
            74-186              JAXUCZ010000008.1  97006495-97006607
            187-320             JAXUCZ010000008.1  97007968-97008101
            321-420             JAXUCZ010000008.1  97016484-97016583
            421-2060            JAXUCZ010000008.1  97022942-97024581
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2060
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="melanocortin 2 receptor accessory protein 2"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
     exon            1..73
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            74..186
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="upstream in-frame stop codon"
     exon            187..320
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..811
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /codon_start=1
                     /product="melanocortin-2 receptor accessory protein 2"
                     /protein_id="NP_001423458.1"
                     /db_xref="GeneID:363112"
                     /db_xref="RGD:1309873"
                     /translation="MEMSAQRLTSNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHK
                     YSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGKPLES
                     DKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHRTTAIDSDVHLQEAIRSSGRPEEEL
                     TRFMQFDIPNFVNTDQNSFGEDDLLISEPPVLLENKPVSQTSRTDLD"
     misc_feature    233..490
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     misc_feature    233..490
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /note="Melanocortin-2 receptor accessory protein family;
                     Region: MRAP; pfam15183"
                     /db_xref="CDD:464550"
     exon            321..420
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
     exon            421..2060
                     /gene="Mrap2"
                     /gene_synonym="RGD1309873"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccactgg cggtggcggc acagcagcgg tgaggctcgc gcaccggagg agctggaccg
       61 tgtaaagcct gcggggaacg acttaattcc tgacactggc aggtatctgg gccctggcag
      121 ttaactcttt ggacattgtg aattggatac gctgtgaagg gctctctgac cagcattgca
      181 aactaggatg gagatgtctg cccagaggct gacttctaac agaacatccc cacagtcacc
      241 atctaactct gactatacct gggaatacga gtactatgag atcggaccgg tttccttcga
      301 aggactgaag gctcacaaat attccatcgt gattggattc tgggttggtc ttgcggtctt
      361 tgtgattttc atgttttttg tgctgacttt gctgacaaag acaggcgccc cacaccaaga
      421 caatgcggag tcctcagaga agaggttccg aatgaacagc tttgtgtcag actttgggaa
      481 gcccctggag tcagacaagg tgttttctcg tcagggcaat gaggagtcca ggtctctgtt
      541 ccactgttac atcaatgaag tggaacactt ggacagggtt aaagtttgcc accgaacaac
      601 agccattgac agcgatgtcc atctccagga agccatcaga agcagtggga ggcctgagga
      661 ggagctaacc aggtttatgc agtttgacat ccccaacttc gtgaacacag accagaactc
      721 ctttggggag gatgatcttc ttatttcgga accacctgtt cttctagaaa ataagccagt
      781 ttcccagaca tcacgtacag acctggactg agacacactt gtgggtgcct tcctgaggat
      841 gtgttctgtt tctgtgcagc aagaaaccac atgctaccta cacttgtgtg tgtgtgtgtg
      901 gagagagaga gagagagaga gagagggagg gagagagaga gagagagaga gggggaggga
      961 ggaggcggca gcgggtgggg aagaggatga tgtttaaagt ttaagaccta ggctaggact
     1021 gggatttagt gatagagggg cagaatttga agatgggagg caccattttg atttggggag
     1081 ggtgattttt ttctctttgg attaaaaatg ccttgacagt attaaagctt ctttattgaa
     1141 acgattagcc aacacatgca attgagctcc ctcctgggtg agggctagtt cgctgcagtc
     1201 gggtctagcc ctttcccacc atcctctgcc tgtaacaagc tgctttgcct ctctggactg
     1261 ccatggcttt acaggtaagg tggcctgtcc ggagtagatg acctatccca gctctagaat
     1321 tttgtgactt tcaaacttag ctataagata agctaagaaa cgcataagca gtagaaaata
     1381 ccacacggca tcgaggcttt catggcaggt tcttcaggtc tcggtgctct cccttcactc
     1441 agtccttcac tgggtcacac tttcggtagg gaaatcttta ctaggagacc aggagacatg
     1501 agacttgcac gcactgtgga cagtgtctct gctgggtgtt gctacagcaa tttatgtgct
     1561 gaacgccccc cccccccgct ttaaactggg atagcttcga ctccagcgac taccagccca
     1621 aactgttttc acaagcatct gtgctcttga agaatggtag agcagattgt tatttggctg
     1681 atgtgagtcc cttctggatg tccctgtgtt tgcatccctg ggctcaccct tctgaactat
     1741 ttggcttcag aacaggaaga taccgctcgc catgtctgcg tggcagatgt gtaggtgacg
     1801 gctgcctggc ttggagctga gagggtccgt gggttttttg ccacagtaac agatgttcag
     1861 gattggagga tgttaatatg agccacatga tgtccgtctc acaaagcaag cagccccctt
     1921 tgctggagtc agaaacaacc cagtcctgca cacacagagt tgtacgcatg agcagctgct
     1981 aatctctggg tggcatcttc tttatgaatt tgttcaccat ttgtcttgct taagttgcaa
     2041 aataaatgca tttgatcgca
//
LOCUS       NM_001436538            3761 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus copine 4 (Cpne4), mRNA.
ACCESSION   NM_001436538 XM_017595791
VERSION     NM_001436538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3761)
  AUTHORS   Takizawa,C., Minematsu,T., Nakagami,G., Kitamura,A., Koudounas,S.,
            Kunimitsu,M. and Sanada,H.
  TITLE     Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh
            exudates swabbed from critically colonised and infected
            full-thickness wounds in rats
  JOURNAL   Int Wound J 20 (4), 1088-1097 (2023)
   PUBMED   36307995
  REMARK    GeneRIF: Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1
            in fresh exudates swabbed from critically colonised and infected
            full-thickness wounds in rats.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_017595791.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.676376.1,
                                           SRR26360176.1952537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               JAXUCZ010000008.1  114076175-114076610
            437-617             JAXUCZ010000008.1  114192287-114192467
            618-797             JAXUCZ010000008.1  114369002-114369181
            798-869             JAXUCZ010000008.1  114396603-114396674
            870-944             JAXUCZ010000008.1  114397782-114397856
            945-1028            JAXUCZ010000008.1  114412388-114412471
            1029-1118           JAXUCZ010000008.1  114417457-114417546
            1119-1217           JAXUCZ010000008.1  114486247-114486345
            1218-1304           JAXUCZ010000008.1  114489898-114489984
            1305-1364           JAXUCZ010000008.1  114491110-114491169
            1365-1498           JAXUCZ010000008.1  114504474-114504607
            1499-1553           JAXUCZ010000008.1  114514015-114514069
            1554-1605           JAXUCZ010000008.1  114515329-114515380
            1606-1739           JAXUCZ010000008.1  114517732-114517865
            1740-1976           JAXUCZ010000008.1  114522794-114523030
            1977-3761           JAXUCZ010000008.1  114530069-114531853
FEATURES             Location/Qualifiers
     source          1..3761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3761
                     /gene="Cpne4"
                     /note="copine 4"
                     /db_xref="GeneID:367160"
                     /db_xref="RGD:1308844"
     exon            1..436
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    312..314
                     /gene="Cpne4"
                     /note="upstream in-frame stop codon"
     exon            437..617
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..2111
                     /gene="Cpne4"
                     /note="copine IV"
                     /codon_start=1
                     /product="copine-4"
                     /protein_id="NP_001423467.1"
                     /db_xref="GeneID:367160"
                     /db_xref="RGD:1308844"
                     /translation="MKKMSNIYESAANTLGIFNSPCLTKVELRVACKGISDRDALSKP
                     DPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDFYFEEVQRLRFEVHDISSNH
                     NGLKEADFLGGMECTLGQIVSQRKLSKSLLKHGNTAGKSSITVIAEELSGNDDYVELA
                     FNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNNLSPAWKSFKVSVNSLC
                     SGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGKQVQWECINPKYKAKKKN
                     YKNSGMVILNQCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGDPRNSCSLHYIHPYQ
                     PNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAINFNEDNPECAGIQ
                     GVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILLILTDGVITDM
                     ADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLRDIVQFVPF
                     RNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKPKCSSEVYESSRTLAP"
     misc_feature    507..857
                     /gene="Cpne4"
                     /note="C2 domain first repeat in Copine; Region:
                     C2A_Copine; cd04048"
                     /db_xref="CDD:176013"
     misc_feature    507..857
                     /gene="Cpne4"
                     /note="C2 domain first repeat in Copine; Region:
                     C2A_Copine; cd04048"
                     /db_xref="CDD:176013"
     misc_feature    order(552..554,570..572,726..728,732..734,762..764)
                     /gene="Cpne4"
                     /note="putative Ca2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:176013"
     misc_feature    order(552..554,570..572,726..728,732..734,762..764)
                     /gene="Cpne4"
                     /note="putative Ca2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:176013"
     misc_feature    900..1238
                     /gene="Cpne4"
                     /note="C2 domain second repeat in Copine; Region:
                     C2B_Copine; cd04047"
                     /db_xref="CDD:176012"
     misc_feature    900..1238
                     /gene="Cpne4"
                     /note="C2 domain second repeat in Copine; Region:
                     C2B_Copine; cd04047"
                     /db_xref="CDD:176012"
     misc_feature    order(945..947,963..965,1131..1133,1137..1139,1155..1157)
                     /gene="Cpne4"
                     /note="putative Ca2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:176012"
     misc_feature    order(945..947,963..965,1131..1133,1137..1139,1155..1157)
                     /gene="Cpne4"
                     /note="putative Ca2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:176012"
     misc_feature    1413..2054
                     /gene="Cpne4"
                     /note="Region: Copine; pfam07002"
                     /db_xref="CDD:462064"
     misc_feature    1413..2054
                     /gene="Cpne4"
                     /note="Region: Copine; pfam07002"
                     /db_xref="CDD:462064"
     exon            618..797
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            798..869
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..944
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1028
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1118
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1217
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1304
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1364
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1498
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1553
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1605
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1739
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1976
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..3761
                     /gene="Cpne4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagaaggt ggaaatctca gctagaagct gccatctcct ggctctcacc cctccctccc
       61 tcccttcctc ctttccttcc tccctcctcg gctccctccc tccttcccca gttccttcct
      121 ctttactcag cgagttcccg agcccagcag ctcctttcac gctgttcacc ctctccccca
      181 gcccccaccc ccaagaatgg agtcggggtt tccagagcga ccaaactctc ctcccagcat
      241 ctttatcctc ctcggctgtt gctaaactgt ccccagagga ccaaagagag gggaggaaaa
      301 tccgaccctc ctaagacctc tttacaacta catcacccag gacctccact ccaaaggcgg
      361 attttgcatc ctgggggcgt gacagacctg tcccgggccg aattctcttt ctagtctccg
      421 aggctggcac acccagaatg aagaagatga gcaacattta cgagtcggct gccaacacgc
      481 tggggatctt taacagcccc tgcctgacca aggtcgagct gcgtgtggcg tgcaaaggca
      541 tttccgacag agatgctctg tctaagccgg acccttgcgt catcctcaag atgcaatccc
      601 acgggcagtg gttcgaggtg gacaggacgg aagtgattcg tacctgcata aacccagtgt
      661 actcaaagct gtttacggtg gacttttact ttgaagaggt ccaacgtctc cggtttgaag
      721 tccatgacat cagcagcaac cataatgggc tgaaggaggc tgacttcctg ggtggcatgg
      781 aatgcacact tggccagatt gtctctcaga gaaagctttc caagtccttg ctaaagcatg
      841 ggaacacagc ggggaagtcc tccatcacgg tgattgctga agaattatca ggcaatgacg
      901 actacgtgga gcttgcattc aatgcacgga aattggatga taaggatttc ttcagtaaat
      961 ccgacccctt cctggaaata ttcagaatga acgacgacgc cactcagcag cttgtgcacc
     1021 gaacagaggt tgtgatgaat aacttaagcc cagcctggaa gtcattcaaa gtatcggtga
     1081 actctctctg cagcggagat ccggaccgca ggctgaagtg catagtgtgg gactgggact
     1141 ccaatggcaa gcacgacttt attggagaat tcacctctac cttcaaggag atgagaggcg
     1201 ccatggaagg gaaacaggta cagtgggaat gcatcaaccc caagtacaag gccaagaaga
     1261 agaattacaa gaattcagga atggtgattc tgaatcagtg caagatccac aagatgcatt
     1321 ccttcttgga ctacatcatg ggtggctgtc aaatccagtt tacagtagct atagacttca
     1381 ctgcctctaa tggagacccc aggaacagct gctccctgca ctatatccac ccataccagc
     1441 ccaatgagta cctaaaggcc ttggtggctg tgggagagat ttgccaagac tacgacagtg
     1501 acaaaatgtt cccggctttt gggtttggtg ccagaatacc cccggagtac acggtctctc
     1561 atgacttcgc aatcaacttt aatgaagaca acccggagtg cgcaggaatt caaggagttg
     1621 tggaagctta tcagagctgc cttcccaagc tccagcttta tggtcccacg aacatcgctc
     1681 ccatcattca gaaggttgcc aagtcagcct cagaggagac aaacaccaag gaggcttcgc
     1741 aatatttcat cctgctgatc ctgacagacg gtgtcatcac agacatggct gacacccggg
     1801 aggccatcgt ccatgcctcc caccttccca tgtccgtcat catcgtggga gtggggaacg
     1861 ccgacttcag tgacatgcag atgctggacg gtgacgacgg aattctaagg tcacccaagg
     1921 gagagcctgt ccttcgagac atcgtccagt ttgtgccctt ccggaacttc aaacatgcgt
     1981 cgccagctgc ccttgcaaag agcgtgttgg ctgaagtccc aaatcaagtc gtggactatt
     2041 acaatgggaa agggattaaa ccaaagtgct cgtcggaagt gtatgaatcg tcccggacgc
     2101 tggcaccgtg aactccacac ttttacggag ttcagaagca ctgttcattc tattcctgca
     2161 ctttaaaata acaaaaacaa aaacaaaaac aacaatatac atttaaagat agcacgtttt
     2221 ggtgattttt aactattttt ttttgcatgt gaagccccaa gccctggatc tgttaagccc
     2281 ttgtattgtt aaagactttt tacaaagaaa tacagtcata acatactctt tacagcatgt
     2341 cgccttgaaa taaaatggta tatgtatcca tttttatacc ggtttgttga aattttgcta
     2401 aatttcttat tatctttaca ctgtaaagca ttttgaaaca tttcctgaat gttgatagcc
     2461 aaagggtata tttggcttac tctcctatag gatgagagac ttttcaaaat ggcagatgca
     2521 tggactgtat tttgcatgtt taaaataatt ataataaaaa taaccttaca ctgtttttgc
     2581 agttgttatc tataatctct ccctgctgag aatggtctct ctctactaaa tacatttatg
     2641 tacctagagg tagtcttttc tgaagtgggc ctgggtcatt tgtcccagtc cccttcttta
     2701 cacactccca tagacacaaa ttccccgaga atcttgttct aatggagttt gctaatgccg
     2761 ggcttgaggt tctgcacgtc tcccaaggtc ctcagtgatg ctaacccatt tcttgcactg
     2821 cactaggact aatgaggttc tgaacttgag gctttcgcca cagagatcac gccaaacaga
     2881 gcagctccta gcctgcttgc ccacagcacc tcttctgccc ccaatagctt agaggaccag
     2941 cctggcccgt ctctgggatg agactagaaa gttaggagac tgattccaga agctgtccac
     3001 cacacatcag cctcccggct ttatagcccc gcctcttcct catccagact gaggagcact
     3061 ccttccagct tgctcccgat tggctaaaag aggcaccaca gcttgctgcg tgggtgggtc
     3121 caattttatg tcagttccta gaaattatct cccaggattc ctcccttgga ctttgagtgg
     3181 aatcttgatc atgccaaata gcaatatggc tgcccaactt tctgttctaa tcacttggtc
     3241 tttgagctca ctgtgggggc accttttggc ctcttttgta tcactcctga gtacaatttc
     3301 cataagcaga agtgccctgg aattgtgtag gatggggaca ttttgtctga atctaaggaa
     3361 gtcttaaaac caaaacaacg acttcttttc ttatgatctt ctctcggaga aatggacaaa
     3421 tgttttataa gctgtaaaag gcacaaaatg aaacttattt ttggtcagaa aaatagtgaa
     3481 gtgtatccta agcaaaaaaa aatctgttgt tggggaagtt tttggttctg tttttttttt
     3541 tgtttgtttg tttgttttaa aggggaaaca ataataatta attaagcaaa tcaaatgtct
     3601 tgtacaattt ccagagttat aattatagat tatcttgcaa atacatgtca accaaatgca
     3661 taacattttg ggaatgatgg tttaaaacaa atgtatgaca gaaaaaaagt cacaaatgtt
     3721 taaattgtat tgttttctga ataaattggg tacttacaga a
//
LOCUS       NM_001191664            3178 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus RB-associated KRAB zinc finger (Rbak), transcript
            variant 1, mRNA.
ACCESSION   NM_001191664 XM_006248868 XM_221920
VERSION     NM_001191664.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 13, 2025 this sequence version replaced
            XM_006248868.4, NM_001191664.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2531008.1,
                                           SRR26643294.45631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000012.1  16488954-16489160
            208-266             JAXUCZ010000012.1  16490269-16490327
            267-393             JAXUCZ010000012.1  16498303-16498429
            394-489             JAXUCZ010000012.1  16498756-16498851
            490-3178            JAXUCZ010000012.1  16499835-16502523
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3178
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="RB-associated KRAB zinc finger"
                     /db_xref="GeneID:288489"
                     /db_xref="RGD:1562875"
     exon            1..207
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            208..266
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2387
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="RB-associated KRAB repressor"
                     /codon_start=1
                     /product="RB-associated KRAB zinc finger protein"
                     /protein_id="NP_001178593.1"
                     /db_xref="GeneID:288489"
                     /db_xref="RGD:1562875"
                     /translation="MSISKGPLSFKDVAVAFSQEEWQQLDSEERTTYRDVMLETYSNL
                     VSVGYDVTKPNVIIKLEQGEEPWTVEGDRHAKRHLEIKKVDDPREGIQENGEKHLQCG
                     DDLHSWRAEKGDEFDEACTLEPPLISPSSGAHSCVSCGKTLESVTELICSDGSYAVEK
                     PDKCFECGKGYRENPEDLNQSEGNSSERDESILQKITILEKPFDYECLEALDRESVFM
                     AHERAYMGEKPYEWNGSGPDFIQISDFSTYHRSQVEMKPFECTQCGKSFCKKSKFIIH
                     QRAHTGEKPYACGVCGKSFSQKGTLTVHRRSHLEEKPYKCDECGKTFCQKLHLTQHQR
                     THSGEKPYECSECGKTFCQKTHLTLHQRNHSGERPYPCSECGKSFSRKSALNDHQRTH
                     TGEKLYTCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLE
                     EKPYECTECGKTFNLNSAFTRHRKAHAEERVQECGECGKPSRLQYLPDHADGLGEKHH
                     GCNECGKTFLENSAFSRHQPVPEGEKTYECNICGKVFSDLSCYTVHYRGHSEEKPFGC
                     SECGKTFSHNSSLFRHQRVHTGEKPYECYECGKFFSQKSYLTIHHRIHSGEKPYECSK
                     CGKVFSRMSNLTVHYRSHSGEKPYECNECGKVFSQKSYLTVHYRTHSGEKPYECNECG
                     KKFHHRSAFNSHQRIHKRGTINVLNVENL"
     misc_feature    273..455
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    273..455
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    1029..1091
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1029..1091
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1113..1175
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1113..1175
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1191..1259
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1191..1259
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1197..1259
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1197..1259
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1212..1214,1218..1220,1224..1226,1230..1235,
                     1242..1247,1254..1256,1296..1298,1302..1304,1314..1319,
                     1326..1331,1338..1340,1380..1382,1386..1388,1392..1394,
                     1398..1403,1410..1415,1422..1424)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1212..1214,1218..1220,1224..1226,1230..1235,
                     1242..1247,1254..1256,1296..1298,1302..1304,1314..1319,
                     1326..1331,1338..1340,1380..1382,1386..1388,1392..1394,
                     1398..1403,1410..1415,1422..1424)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1269..2348
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1269..2348
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1281..1343
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1281..1343
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1365..1427
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1365..1427
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1449..1511
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1449..1511
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1533..1595
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1533..1595
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1617..1679
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1617..1679
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1779..1841
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1779..1841
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1863..1925
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1863..1925
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1947..2009
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1947..2009
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2031..2093
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2031..2093
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2115..2177
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2115..2177
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2130..2132,2136..2138,2142..2144,2148..2153,
                     2160..2165,2172..2174,2214..2216,2220..2222,2232..2237,
                     2244..2249,2256..2258,2298..2300,2304..2306,2310..2312,
                     2316..2321,2328..2333,2340..2342)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2130..2132,2136..2138,2142..2144,2148..2153,
                     2160..2165,2172..2174,2214..2216,2220..2222,2232..2237,
                     2244..2249,2256..2258,2298..2300,2304..2306,2310..2312,
                     2316..2321,2328..2333,2340..2342)
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2199..2261
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2199..2261
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2283..2345
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2283..2345
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            267..393
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            394..489
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
     exon            490..3178
                     /gene="Rbak"
                     /gene_synonym="RGD1562875"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcgccgc tgtgactcct gcaggtccgt cgtcgaggct accttccttc ccacagcttt
       61 tgcacccgct aagctggagt cgccgagcct gcgggaacga gaccggagct tccggggcgg
      121 cagcgaacag actcagctgt gctggcctgg gaggcctaga gggagctcgg cgcggaggac
      181 gacagtggcg gcggggccgt ctgctgggtc agtcgtcagt gttgtctacg gtttcccaag
      241 aggagcaaaa gatgagcata tcaaagggcc cactgtcatt caaggatgtg gctgtggcct
      301 tctcccagga ggagtggcag cagctggact ctgaggagag gacgacctac cgggatgtga
      361 tgctggagac ctacagcaac ctcgtctccg tggggtatga tgtcaccaag ccaaacgtga
      421 ttattaagtt ggaacaggga gaagaaccct ggacagtgga aggtgaccgc catgctaaga
      481 ggcatttgga aatcaaaaaa gttgatgacc ccagagaagg aatccaggaa aatggcgaga
      541 aacatctgca gtgcggtgat gatctccaca gctggagagc ggagaagggg gacgagtttg
      601 atgaagcctg caccctagaa ccacccctca tttcccccag ctcaggcgct cacagctgtg
      661 tctcctgtgg gaagactttg gaatctgtta cagaactgat ttgcagtgat ggaagctatg
      721 cagtagagaa gcccgacaag tgttttgagt gtgggaaagg gtacagagaa aaccctgagg
      781 accttaacca aagtgagggt aactcttctg aacgtgacga aagtattctg cagaaaatca
      841 ccattttgga gaaacccttt gactatgagt gcttggaagc cttagacagg gaaagtgttt
      901 tcatggctca tgagagagct tacatggggg agaagcccta tgaatggaac ggttctggac
      961 cagacttcat ccagatatca gacttcagta cgtatcacag atcacaagtg gaaatgaagc
     1021 ccttcgaatg tacgcagtgt gggaagtcct tctgtaagaa gtccaaattc atcatccatc
     1081 agagagcgca cacaggagag aaaccgtatg cttgcggtgt gtgtggaaag tcctttagtc
     1141 aaaaggggac cctcactgta catcggaggt cacacttaga ggagaagccc tataagtgcg
     1201 atgagtgtgg gaagaccttc tgtcagaagt tacacctcac acagcaccag agaactcact
     1261 caggagagaa gccctacgaa tgtagcgagt gcgggaagac cttctgccag aagacgcacc
     1321 ttactctaca ccagaggaat cattcagggg agaggcccta tccgtgtagt gaatgcggga
     1381 aatccttctc ccggaagtct gccctcaatg accatcagag aacacacaca ggagagaagc
     1441 tctacacgtg taacgagtgt ggtaagtcct actaccggaa gtccaccctc atcacgcacc
     1501 agagaacaca cacgggggag aagccctatc agtgtagtga gtgtgggaag ttcttctctc
     1561 gcgtgtcgta cctcaccata cactatagga gccatttaga agagaaacct tatgagtgta
     1621 cagaatgtgg gaaaaccttc aatctaaact ccgccttcac caggcaccgg aaggcccatg
     1681 cagaagagag agtgcaggag tgcggtgagt gtgggaagcc gtcccggctg cagtatctcc
     1741 ctgatcacgc tgatggccta ggagagaagc accacgggtg taatgagtgt gggaagacct
     1801 tccttgaaaa ctcagccttc agcaggcacc agcccgttcc cgaaggggag aaaacttacg
     1861 agtgtaacat atgcgggaag gtgttctctg acctgtcgtg ctacactgtg cattacagag
     1921 gtcattcaga agagaaaccc tttggctgca gcgagtgtgg gaaaaccttc tctcataatt
     1981 catccctctt cagacatcag agagtacaca caggcgagaa gccgtacgag tgttacgagt
     2041 gtggcaagtt cttctcgcag aagtcctacc tcactatcca tcacaggatc cattcaggag
     2101 agaagccgta cgagtgtagc aagtgtggca aagtgttctc tcggatgtcg aacctcaccg
     2161 tccactaccg aagccattca ggagagaagc cctatgaatg taatgagtgt ggaaaagtct
     2221 tctcccagaa gtcgtacctc actgttcatt accggactca ttcaggagag aagccttatg
     2281 aatgtaacga atgtgggaaa aaattccacc acagatcagc cttcaatagc catcagagaa
     2341 ttcataaaag agggactata aatgtactta atgtagaaaa tctctgacgt ctcaattttt
     2401 aaaaagacat atggttatag tgaacattgg gagtccaata ggtagtcaag ggtgcccccc
     2461 caaactttta atatatgtgg tgctgggaac tgaatatggg ccctttgcat gctatagaaa
     2521 ttctgcactg agctggactg cagtgactca cgagttgagc acccctgctc ttaaagagtg
     2581 tgaagtccta aaacaaaatc cattttaacc tgaattttca gagcagaatc tgtaaagatt
     2641 gggcaagaag caaaccgttt atgggacact aggtaatttt tacaggagtg aaacttcgaa
     2701 agtatttaat atttattttt tatttaaatt gtatttacat atcagggagc gttgccgaga
     2761 actgtcagcc gatgagtata actcaccttg gacacatacg ctaaaagcca tatttctgat
     2821 gtcagaccag gtgtctatag acaggatgca agaagccgtc agctctgagc aaagttatga
     2881 aatgaaatta taaagctagc gcttggccac gaggatgact aaaccacggc acctctgctg
     2941 ttctagaagt cgagcagcca ttctatgcaa tgtttgccat ctccgcctcg aacgattggt
     3001 ggaaacctgg tatccaggat tagcaacgcc tgttacagtg ggtccattgg tgggatatgc
     3061 tatgtgatcg ggaagtacat agttttctag gtcactgctt gccaggagag cggttttgta
     3121 aaaaattttc aactggaatt gagcaaaaaa ttttttaaaa tactattttg ataaacta
//
LOCUS       NM_001436567            6783 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus kelch repeat and BTB domain containing 11
            (Kbtbd11), transcript variant 3, mRNA.
ACCESSION   NM_001436567 XM_006253391
VERSION     NM_001436567.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253391.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.508413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000016.1  81339612-81339818   c
            208-6783            JAXUCZ010000016.1  81318596-81325171   c
FEATURES             Location/Qualifiers
     source          1..6783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6783
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB domain containing 11"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
     exon            1..207
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     exon            208..6783
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    817..819
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="upstream in-frame stop codon"
     CDS             931..2832
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB (POZ) domain containing 11"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     11"
                     /protein_id="NP_001423496.1"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
                     /translation="MENSVAPFVLYPGTEPRTPGEDSLPLPAEEEGAASPAQTPCSLS
                     ASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPQECARP
                     EEPASPEEPPSRREHARPVELESLDELGEPVPVPPGVGSEHGEPDLVIEVAGRRLRAH
                     KAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGCMAGVRPDNVAEVVAGAR
                     RLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLSELRDAAYRFMCDHYLEVLREP
                     AVFGRLSGAERDLLLRRRLGTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVY
                     CYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFVAGGVAPAGPDGRARPSDQVFCYN
                     PVTDCWSTVRPLRQARSQVQLLALDGHLYALGGECLLSVERYDPRADRWTAVAPLPRG
                     AFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFL
                     YRFDLCGSRGDAQAATGSGGGVSVFRYHCLAKQWSQCAAHLRPPGAPAGLQPFRCVAL
                     DGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEK
                     PDRGEQGAA"
     misc_feature    1360..1668
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1360..1668
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1639..1869
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1639..1869
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1951..2652
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1951..2652
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1996..2142
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1996..2142
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2152..2274
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2152..2274
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2416..2568
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2416..2568
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
ORIGIN      
        1 ggcgcgctcc cggcattggg aaagcgcgca gcatctcagc gctcgcacag gtgcgcggag
       61 ggttcgctcg ccccgggggc gctcccacag gtgcgcgcga atggtcgcgt gcgcatgcgt
      121 gtcagacccc cacgcccccc ggccaggctg cgagtcctgg gctccggtgg gttgcaggag
      181 tggagggaga gcgtcaggct gcgagcggag caaggaggtg gagagtgatg tggggacctg
      241 acggggaagg aagcagcgga ggctcccgat gacaaatgag gaaaacctgg gtacacacac
      301 agacgcttcc tttccagcca ttcacccata ggtggagtgc ttccctaggt ggacagtgtg
      361 ggtgggaagc tgccacccag acacacatct cagctggatt ctcggctgca cagcgggagt
      421 ctgtagaaca gagcggaagc taaggattta agtgtggcca ccgcccctgg aagatttgct
      481 ggtcctgggt ctacagtact gtgataggag gtgactcagt gggtccaccc agagtccaag
      541 gacgcccatg cttgtggccc agacacactt aacctcagtt ctccaaagga gcaatacaaa
      601 ggagcctcag ctccgagcag tcgatgtgta aactgcaaaa aaacaaagca aaaaccaaac
      661 ccctctttgc caccaggcta attgacctcc gccccacgga cgtagcctga gttgaagttc
      721 ccctttcgaa agttcagtga gagttggggc gttgagagga gagtgggaag ggcaaggtgg
      781 gagtggcgtg aacagggggt ggacacatgt gaaatctgat ccggtgccaa ggaaagggtt
      841 tgtgctgcca gagaccccag ggcaaagctc tacctccacc gggcatgtgt ggctcctgag
      901 ctggccgact gcacacgaca caacccactc atggagaact cggtggcgcc tttcgtcctc
      961 tacccgggga ctgagcccag gactccggga gaggacagcc tgcctctgcc agccgaggaa
     1021 gagggcgctg catccccagc gcagacaccc tgcagtctaa gcgcctcgct gtgtttcagc
     1081 tccggggacg actccccgcc gcagtctcgc gcctctgccg cggagggctc cgaagcttct
     1141 ccgccttctc tccgcagcga cctgcgtgtg gtggagacgc agtgggatgt cagcagcgcg
     1201 gcgtccccag agtccccaca ggagtgcgcg cgcccggaag agcccgcgtc gccggaggag
     1261 cccccttccc gccgcgagca cgcgcgtccc gtggagctcg agtctttaga cgagcttggg
     1321 gagcccgtgc ctgtgccgcc cggggtcggg tcagagcacg gagagcccga cttggtcatc
     1381 gaggtggcag gtcgccggtt gcgggctcat aaggcggtgt tggcggcgcg cagcgactac
     1441 ttccgcgcgc gtgcgtcgcg ggacgtgctg cgggtgcaag gcgtgagctt cactgccctg
     1501 cggctgctgc tggccgacgc gtacagcggg tgcatggccg gcgtgcgacc ggacaacgtg
     1561 gccgaggtgg tggccggcgc gcgccgcctc cagctgcccg gcgctgcgca gcgcgccacc
     1621 gaggccatgg cgccgcagct gagcctggac aactgctacg aggtgctgag cgcaggcaag
     1681 cggcagcggc tgagcgagct gcgcgacgcc gcctaccgct tcatgtgcga ccactatctg
     1741 gaggtgctgc gcgagccggc cgtcttcggc cgcctgtccg gtgcagagcg tgatctgctg
     1801 ctgcggcgcc gcctgggtac gggccgcgcc tgtctgctgg ccgctgccct ggggacaacc
     1861 ggggagcgct cgggcagtcg accgcagagt ccgtccgggg acgcagagtc gcgcggggac
     1921 gcagcggttt attgctacca ggcggaggcc ggggagtggc gagagctgac tcggctgccc
     1981 gagggcgcgc ccgcgcgcgg ctgcggactc tgcgtgctct tcaactacct cttcgtggcg
     2041 ggcggtgtgg ctcctgcggg tccggatggc cgcgcgcgcc cgtcggacca ggtgttttgt
     2101 tacaacccgg tcaccgactg ctggagtact gtgcgacccc tgcgccaggc gcgctcgcaa
     2161 gtgcagctgc tggctctgga cggccaccta tatgccttgg gcggcgagtg cctgctcagc
     2221 gtggagcgct atgaccctcg agctgaccgc tggaccgcgg tggccccgct tccccggggc
     2281 gccttcgcag tggcccacga ggctgccacc tgtaacggcg agatctatgt gtccgggggc
     2341 tcactcttct accgcctgct caagtacgat ccccggcgcg atgagtggca ggagtgccca
     2401 tgcagcagca gccgagagcg ctctgccgac atggtggccc tcgacggttt cctctatcgc
     2461 tttgacctgt gtgggagccg cggtgacgct caggctgcaa ctggttcagg tggtggggtc
     2521 agcgtgttcc gctaccattg cctggccaag cagtggagcc agtgtgctgc acacctgcgg
     2581 ccccccggcg cacccgcagg cctgcagccc tttcgttgtg ttgccctgga tggtaccatc
     2641 tactgtgtga gccgcgctgg gacctggcgt ttcgtgcctt ctcaggacac tgaggctggc
     2701 agcgatatgg gacccggtgg cagttttgaa cctgagcccc tgggatcccc gctggatgtc
     2761 cggggcgtac tctttccatt tgtgctcaac ctgcctgaga agccggaccg tggggaacag
     2821 ggtgcggcct aggacaggat cagctgggca gctccactgt ccagcacttg tggtggtggg
     2881 gggctccaaa gaatgggctg ggccccaccc ccagtagggg agggagggca aagaggtctc
     2941 aggaatggag gacgcgcaca ggccaggctg ctggccacac tgcatcgtgc aaacgctttg
     3001 agagtagaag cttcaactgg cgctgaagac atttttgcaa tgctgtttta agccccgctt
     3061 tgcagtgctg gattctgctt ttgcttcgct tgttcggggg gggggggtgt catagcttaa
     3121 agtgtgggaa gatagataca gagaagccca tacctaaggg aagaagtaga ggaggccagg
     3181 ataaagtggg acgcaggtgc agactcgggt ataatgagga acctgcccag tcccctcctt
     3241 accagcgagt gcaaggttct caaacctgaa tggggtccta aagtaggcca ggtatccttg
     3301 caaaccacag agagacggtc aaaccccgct ctgaggttta agtcgataac ttagaagatc
     3361 tgcacgacct aaccaggacc taaaaagttc accgtgtgtt cgcaagtagg ttcaacttca
     3421 aacagtaact tctcaaatac tgaaggcaaa gggtagttga ccagtagagt tgccgttgtt
     3481 gctgactgaa cggaaaagaa cctcaggtca ggagaccctg gtagttctgc atgttcaccc
     3541 cctttcccgt cttagaatga accagggaga tttttttttc cttcctagaa caggaggtta
     3601 aaatcatgtt ttgacagttg catgctttga accctctgct cggttgtttt gaacgtatct
     3661 tctgtgattc tgaagaggga gattaattta caaccacctc aaagaaagtg tatgtgtgta
     3721 tggggtgggg ggtgatatgc tatggaggag gaaaaggaga aacgcaccgt tttgagtgta
     3781 gtttagcaag caagtggcat tcatttaact tcctaaacac cctactcgag tccaaaggag
     3841 actcagactt aggttgcagg accaaaacca agtccgttca ttttctctca tgtgttgggc
     3901 tgttgtgctt ttgagaatat acaggcaagg atccctgttt aaagaacaga atgtgtgctc
     3961 ccaggtaact ggtttagatt ccatacctaa ccctgctgtt ttataacagt gggggtccta
     4021 agtattcatc gtttctggaa cataagaggt agccccgtgt tcaccgtgcc atctctgtag
     4081 aaatcactgg ttagctgaga accaggctac actttatagt ctgttctgaa aggtcacggt
     4141 gaagtgtgtt tagaaacagc cagcttgaat cttctgcatg acccagggga atggagttta
     4201 tagttcctgt ttgtatgttc tggtctcttt gtgcttgttc gtggttactc ataaaccaag
     4261 agaatgtctt ggccacttgg ttaatcatct taagaaaaac agacttccta ttgcctggtt
     4321 ttattggtcc tttttgaggg gcgtcctggg gaaaggcttg cagatgagcc aagggagccg
     4381 gtgcctagag acacaccttc atcgctgaag taccagactt acagaatact gccacgtgac
     4441 gtttgcctaa gaagccgttc ctctgacatt cacttttgaa attggtcctc tagggtgaca
     4501 tgtccccaga gagggcagat gtacaccaga caggagagtc ttcctgtggg catagtgccc
     4561 cacagagcac aaacaaaccc caaggaagtc aaaaggatta atgtacttac ttgcagatcg
     4621 tgaaaggaca ttagttcgtc gatcacgaat agaggccctg ctttttgaga acttataaag
     4681 tatcttgtgt cctgtttata aacagtgacc cccactgaaa acaaatgcta caggccttgg
     4741 cacatctcag caaccatgca ttttgttcct gggatctgga agacttacta cccatctgtc
     4801 ttagattcac tttccgtgat aaaaagcaac ttaagggaga gaggtttcat tctggctcag
     4861 agtttgggtt acagcccttc atactgtgga agtcccaggg cagggctgtg agggggcggg
     4921 tgcttctgta cctgcagtca agacacagtt aatgcatact gtctatggtg gtttgcatat
     4981 gccctgcccc agggaatggc actgttagga ggtgtggcct tgttgcagtg ggtgtgtcac
     5041 tgtggtcgtg ggcttaagac cctcatccta actgcctggg agccagcctt cttctagcag
     5101 ccttcagatg aagatgtaga actctcagct cctcctgcac catgcctgcc tggatgctgc
     5161 tgtgttccca ccttgatgat aatggactga ctttctgaac ctgaaagcca gccccaattc
     5221 aatgctgtcc taataagagt tgccttggtc gtggcgtctg ttcacagcag taaaacccta
     5281 actgagacac cgactccact cagctgtctc cacgcataca ttcccaggac ccggttagaa
     5341 aatgctgcca cccataggaa gaagctcttt tcattccaat taatgtaatc aagttaactc
     5401 cccacagacg tgcttagcag cccaactccc aggtgactct agattctgtt cacagcaacc
     5461 tgcacgccca cagcaagtgt tggtattggt ttggtagtga gggtagcggg gtttgagaag
     5521 gatgtgtctc cagtgtgtga accaggtagg tgctttctcc atgctggtct cattccgcct
     5581 ccaactccac ctgggagttt ggtcggtgtc agcacagatc tgactatcag ctaagagtca
     5641 aataaggcta cgatgcctgg aacacccagc ctcagctctt aggacattaa cccttgtaca
     5701 cagacaccct gagtgtttga agggacagca ctcttaagga gtaaatgatt gatacactaa
     5761 gattgacctt ctgtttggtt gatgggtaac tgcatttata tctccaaggt ttgtttggaa
     5821 tcttagcaac gagctgatgt ttctggattt ttcttttctt tctgttttgt actttggcat
     5881 ggggcgagcc ccacctctag ggcagacact tggcatctcg gcagacttgg aatgtggtga
     5941 ttctgcttct gaggaaatga cggcaggagt ttcttttact ctaaggaaaa tgaacgttgt
     6001 ggaaatcttg ttggctgctt agtgtcttac gtgttttctg tttttgctgc acaagcaaag
     6061 aaaggaaaaa gaacagggtc cctctagccc tggtgggtga ccgtgtgact gcactttgtc
     6121 cagtgttgga actgagggcc tctgagggtg tgctgctctc tgctgaagtc aagatagagt
     6181 caggacatga tggtttggaa cgtttcagtg gcagatgtga gcccaatagc tctttggtgt
     6241 agtgtttcac tttaggggcc ctccctagct tgcagaaagt cttcattttg atacttggtt
     6301 ttgttttgtt ttatgtcccc attttttctg taatattatt cacaagaagg taatgactcc
     6361 agctgaaagt ggaactctgc cagcactctc tgcctctgtg tttatccaag cagacatgtc
     6421 agggatgctc tgcccacatc catgaagagg gcagcaccgt gagatgctga gggatctggc
     6481 aggaagtggg tcctggcagc agcttcacct ggctttgtgg ccaggtttgg gtgtctgcgt
     6541 attccaatgt gaggttgctc tcccccgccc cgtcatgctt cgtagagctt tgactagtac
     6601 ctactactaa ctagtatgta cccgtggcca tttactaaag atccctacct gtctgaggca
     6661 aagtcgggcc agctgtctgt cactgtgctc cacacttgag tttttaccct aggcataaat
     6721 gctctaaaac cttgtatgtt tgtcacctgt gccaagacga aataaactat gtggaaactc
     6781 cca
//
LOCUS       NM_001436581            2492 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 7, mRNA.
ACCESSION   NM_001436581
VERSION     NM_001436581.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2492)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2492)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2492)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2492)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2492)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2492)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2492)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2492)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2492)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.616331.1,
                                           SRR22582424.2217263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000016.1  82902867-82902983   c
            118-192             JAXUCZ010000016.1  82902097-82902171   c
            193-299             JAXUCZ010000016.1  82877461-82877567   c
            300-421             JAXUCZ010000016.1  82872461-82872582   c
            422-731             JAXUCZ010000016.1  82871245-82871554   c
            732-800             JAXUCZ010000016.1  82870780-82870848   c
            801-952             JAXUCZ010000016.1  82869556-82869707   c
            953-1119            JAXUCZ010000016.1  82869032-82869198   c
            1120-1198           JAXUCZ010000016.1  82868362-82868440   c
            1199-2492           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2492
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..117
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..192
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    177..179
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     exon            193..299
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..421
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..731
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..1346
                     /gene="Tfdp1"
                     /note="isoform 2 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 2"
                     /protein_id="NP_001423510.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKN
                     IRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQ
                     LQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDK
                     FEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYVTEMA
                     QGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGED
                     DDDDDDFNENDEED"
     misc_feature    474..692
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    474..692
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(705..707,717..719,726..731,735..740,747..752,
                     756..761,768..773,780..782,789..794,801..803,810..815,
                     819..824,828..836,843..845,876..911,915..917,948..974,
                     978..980,984..986,990..992,1008..1013,1017..1019)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(705..707,717..719,726..731,735..740,747..752,
                     756..761,768..773,780..782,789..794,801..803,810..815,
                     819..824,828..836,843..845,876..911,915..917,948..974,
                     978..980,984..986,990..992,1008..1013,1017..1019)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    705..845
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    705..845
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    711..1127
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    711..1127
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(777..779,786..791,798..800,897..899,924..926,
                     930..932,975..998,1017..1019)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(777..779,786..791,798..800,897..899,924..926,
                     930..932,975..998,1017..1019)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            732..800
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..952
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1119
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1198
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2492
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtgagcc cgcgtcccgg cgccgctggc tcagggcagg gaccgccagg gccggacctc
       61 cgggccggcg cccccgcgcc cccgtcgtcc gccccgcgcg ccccgccggc cagccagata
      121 agtccggttt cttctgtgga gggtacgcag ttaaagcctt gatttcctgg atctggtaac
      181 atggcaaaag atgtgtggtg tctcttgtgg ctgtgcaccc atccacagtg aacacactgg
      241 ggaagcagct tttgccaaaa accttcggac agtccaatgt caatatcaca cagcaagtgg
      301 tgattggcac gcctcagaga cctgcagcag ccaacactat tgtggtagga agcccacaca
      361 ctcccaacac tcactttgtg tcccagaacc agacgtctga ctcctcacct tggtctgctg
      421 ggaagcggaa caggaaaggt gagaagaatg gcaaaggcct gcggcatttc tccatgaagg
      481 tgtgtgagaa ggtgcagagg aaagggacga cctcctacaa tgaggtggcc gacgagctgg
      541 ttgccgagtt cagcgccgct gacaaccaca tcttacccaa cgagtccgcc tacgaccaga
      601 agaacatccg gcggcgtgtg tacgatgcct taaatgtgct gatggccatg aacatcatct
      661 ccaaggagaa gaaggagatc aagtggatcg gcctgcccac caactctgct caggagtgcc
      721 agaacttaga ggtagagagg cagcggaggc tggagaggat caaacaaaag cagtcacagc
      781 tccaggagct catcctgcag caaattgcct tcaagaactt ggtgcagaga aatcgccaag
      841 cggagcagca ggcccgcagg ccaccgcctc ccaactctgt catccacttg cccttcatca
      901 ttgtcaacac cagcaggaag acagtcatcg actgcagcat ctccaatgac aaatttgagt
      961 atctgttcaa ctttgacaac acgtttgaaa tccacgatga tatcgaggtg ctcaagcgca
     1021 tgggcatggc ctgtgggctg gagtcgggca gctgctctgc tgaagacctc aaggtggcga
     1081 gaagtctggt accaaaagct ctagaaccgt atgtgacaga gatggctcag ggatccattg
     1141 gcggagtatt tgtcacgaca acaggttcta catccaatgg cacaaggctt tctgccagtg
     1201 atttgagcaa tggtgcagat gggatgctgg ccacgagctc caatgggtct cagtacagcg
     1261 gctccagggt ggagacccct gtgtcctacg ttggggagga tgacgacgac gacgatgact
     1321 ttaatgagaa cgacgaggag gattgattac tcaactgtag acccttctcc cctcagtcag
     1381 cttcaggaaa aacgtataga gaaaagaagc ttttgaagtg gggctttccg ttctttctgg
     1441 cctactccca agaagatgcc gccgagttgt ggagttagat atgcagctcc aagtaaggag
     1501 tgtgcccgcg gtgtgagcga gctgtggatg tgtcgtgaag ccagcgtgct agagcagagc
     1561 ctgtatctac cttttaggat tttatggttc ctctttcttt cttttttttg tttatcttct
     1621 ttcctttctt ttttaagttt gaagcttgtt ttgcccctca acagttgttg ctggtttgct
     1681 gaggaggctg tgctgcgccc ccaccggtga cagtggtaaa gcgctgcccg cctcgggtgt
     1741 gcggcgccca ggtggtggac agccaggcgt taggatggat tttcccattt gtcaaatcat
     1801 gcagagtcca gagaacaagg cgatagcaaa gctccactgt taacgctgcg cgccatacgt
     1861 ctcatgactg tttttcctta aattatactg actgtccagt tccatcaatc aaccttttct
     1921 caagcagcag caaagcgaga agtagtgttt cttgtttgtt tgttttgttt tgtttggaag
     1981 aagtttactg ccacgctggc gcagctatgg aaattgtcta gaaagtttgc ttatggtaaa
     2041 tttgcctgat ttcttacagg ctacgtttgg aaacttttta ttatatagtt tacatactta
     2101 taagtctatc atttaaagac gtgtactgaa acaaatgttg tatttgtttc ataagcatct
     2161 tcctgtaatc tattataaaa ttgaaattaa acatagagaa tgttttaaca gttttttaac
     2221 tcaaaatttg tcaatcattt ttaatagttc tttttttata aaaagaaaaa ggaatttaag
     2281 gacaggcaat agtctcttaa aatttattca caagaaccgt taactgcaca gctgccctta
     2341 gctgcctgtt ctaaatgatg gtctttttat tgaaacacaa ataaactttt ctgtaatatt
     2401 ttatggaata taaagagact ttaattgttt gacctgttta actaagcact gttagttttt
     2461 attaataaaa cgcgcatggg cattttaaac aa
//
LOCUS       NM_001177684            1830 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus cysteinyl-tRNA synthetase 2, mitochondrial
            (Cars2), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001177684 XM_001076059 XM_002728438
VERSION     NM_001177684.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced NM_001177684.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166536.1, SRR26643288.56382.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000016.1  84652088-84652321
            235-285             JAXUCZ010000016.1  84652506-84652556
            286-403             JAXUCZ010000016.1  84654131-84654248
            404-475             JAXUCZ010000016.1  84660918-84660989
            476-581             JAXUCZ010000016.1  84661472-84661577
            582-665             JAXUCZ010000016.1  84666898-84666981
            666-798             JAXUCZ010000016.1  84672843-84672975
            799-932             JAXUCZ010000016.1  84673517-84673650
            933-1000            JAXUCZ010000016.1  84677454-84677521
            1001-1067           JAXUCZ010000016.1  84684762-84684828
            1068-1206           JAXUCZ010000016.1  84685053-84685191
            1207-1330           JAXUCZ010000016.1  84685714-84685837
            1331-1429           JAXUCZ010000016.1  84687155-84687253
            1430-1636           JAXUCZ010000016.1  84688576-84688782
            1637-1830           JAXUCZ010000016.1  84689061-84689254
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1830
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:361184"
                     /db_xref="RGD:1311612"
     exon            1..234
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1708
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /EC_number="6.1.1.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable cysteine--tRNA ligase, mitochondrial"
                     /codon_start=1
                     /product="probable cysteine--tRNA ligase, mitochondrial
                     isoform 1"
                     /protein_id="NP_001171155.1"
                     /db_xref="GeneID:361184"
                     /db_xref="RGD:1311612"
                     /translation="MLRALRPGPGAPLLRAALVLGRRGRAWQRPQGQDTGVQVHNSLT
                     GKKEPLIVGRSDAVSWYSCGPTVYDHAHLGHACSYVRFDIIRRILTSVFGCNVVMAMS
                     ITDVDDKIIKRANEMNVSPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIISF
                     IQGIIAHGHAYATATGSVYFDLRARGDKYGKLVNTVPSATAEPAVDSDKRHSSDFALW
                     KGAKPQEVFWASPWGDGRPGWHIECSAMASEVFGSQLDIHTGGIDLAFPHHENEIAQS
                     EVFHQCQQWGNYFLHSGHLHVKGKEEKMSKSLKNYITIKDFLQTFSPDVFRLFCLRTN
                     YRSAIDYSDSTLEEARHLLLGLASFVEDARAYVKGQLICGPVGEDVLWERLASTKKAV
                     KAALANDFDTPRAVNSILDLVHHANRQLRAVSKEAGGPRSPTVFGAIVAYVEQFFETV
                     GISLAKRQCVSGDSSTVALHCVVDELVRFRLKVRQYALATPGATGEARKQQLQERQPL
                     LEACDALRQDLMTHGINVKDRGHAASTWELLDPRTKHQKPGT"
     misc_feature    122..1696
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     misc_feature    122..1696
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     exon            235..285
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            286..403
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            404..475
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            476..581
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            666..798
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            799..932
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1000
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1067
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1206
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1330
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1429
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1636
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1830
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcccggc ctgcaggatt ttgccttacg cctgttcgct ggatctgtcc ccaatatgct
       61 gagggcgctc cggcctgggc cgggcgctcc gctgctccgg gccgcgcttg ttctcgggcg
      121 gcgcgggcgg gcatggcaac ggccacaagg ccaggacacc ggtgtgcagg tgcataacag
      181 cctcacaggc aagaaggagc cgctgatcgt gggccgctcg gacgcagtct cctggtatag
      241 ctgtggaccg actgtgtacg accatgcgca ccttggccat gcttgctcat atgtcagatt
      301 tgacatcatc cgaaggatcc tgaccagtgt gtttggatgc aatgttgtca tggcgatgag
      361 cattaccgat gtggatgata aaataatcaa gagagctaac gagatgaacg tgtcgcccgc
      421 ttctcttgcc agcctttttg aggaagaatt taaacaagac atggcagccc tgaaggtcct
      481 gccgccaacc gtgtacttga gagtcaccga gaacatccct cagatcatct ctttcatcca
      541 aggcatcatt gcccatggcc atgcttacgc gacagccaca ggtagcgtct actttgattt
      601 gcgagcacga ggggacaagt atggcaagct ggtcaacacg gttcccagtg cgactgcaga
      661 gccagcagtt gactctgaca agaggcacag cagcgacttt gccctgtgga agggagccaa
      721 accccaggag gtgttctggg cctcaccgtg gggagacggc cggcccggat ggcacatcga
      781 gtgttctgcc atggccagcg aggtgttcgg aagccaactg gacatccaca ccggcggcat
      841 agacttggct ttcccacatc atgaaaatga aatcgcacag agtgaagtct tccaccagtg
      901 ccagcagtgg ggaaattact tcctacattc gggtcatttg catgtgaaag gcaaagaaga
      961 gaagatgtcc aaatccctaa aaaactacat tactattaag gacttcctgc agaccttctc
     1021 tcccgatgtc ttccggcttt tctgcttgcg caccaactat cggtcagcca ttgactacag
     1081 tgacagtacc ctggaggaag ccaggcacct cctgctgggg ctagcctctt ttgtggagga
     1141 tgcacgagcc tatgtaaagg ggcagctgat ctgtggccct gttggggaag atgtgctgtg
     1201 ggagaggctg gctagcacca agaaggccgt gaaggctgca ctagccaatg actttgacac
     1261 accgagggca gtgaactcca tcctggacct tgtgcaccat gcaaacagac agctcagggc
     1321 agtctcaaag gaagctggtg gcccgagaag tcccactgtg tttggggcca tcgttgccta
     1381 cgttgagcag tttttcgaga ctgttgggat ttctctggcc aagcgacagt gtgtttcagg
     1441 agacagcagc acagtagccc tgcactgtgt ggtagatgaa ctagtgcgct tcaggcttaa
     1501 ggtccgccag tatgcactgg ccacgcctgg ggccaccggg gaggcccgga aacagcagct
     1561 ccaggagagg cagcccttgc tggaggcatg tgacgcactc cgccaggacc tcatgaccca
     1621 cggcatcaat gttaaggaca gaggccatgc agcctccaca tgggaactgc tggatccgag
     1681 gacaaaacac cagaagcccg ggacttgagg atgaggcagc tgcagtccac gtgcctccac
     1741 gcatggcatc tgctttcttt gtggtgaact ttgtattaaa aactttatat taaagttgct
     1801 aattgtggct gtttagccac agtaaagtga
//
LOCUS       NM_001436573            1464 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 7,
            mRNA.
ACCESSION   NM_001436573
VERSION     NM_001436573.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1853899.1,
                                           SRR26360194.1520438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000016.1  82203615-82203756
            143-289             JAXUCZ010000016.1  82217914-82218060
            290-424             JAXUCZ010000016.1  82234137-82234271
            425-853             JAXUCZ010000016.1  82264721-82265149
            854-1042            JAXUCZ010000016.1  82268074-82268262
            1043-1464           JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1464
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..142
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            143..289
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            290..424
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            425..853
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1116
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 6 is encoded by transcript variant 7;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 6"
                     /protein_id="NP_001423502.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSRNKKRKWRAKLRLRRKREAGLAARASAASFTYEPESSEEAEV
                     EGDVGGEEEEDPESSVADPAQEDTELASSRADSLLSFLKSTQEIYFYDASREDPAVST
                     EAAEELLRLLESGRLPPADVLILDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHARI
                     ISAFFNYWITQILPEKRSE"
     misc_feature    <751..>1062
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     misc_feature    <751..>1062
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     exon            854..1042
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1464
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcagggt aggcaggaag cgcgaaacgc gaacggagac tggatctgag
      121 atagccaagg gtggcggacg tgtgtttact gagaaagtgc tgaagagact tttccctaac
      181 gtctcaagtg gtcaagaaaa gggcactccc cagactccag ctttggacac accatccaag
      241 gactcgaccc ctgaagcggt acagcagaag cccgttcgtg gtctgacagc tggtgacatt
      301 aagatccaac ctgagcgtcg cctctacacc gtgagtctgc ctcctccagg gtatatccct
      361 tgtttgccag aaccgaccag ctgtgcagat tccgaaaacg cctccagcgg tggtgacaca
      421 gaagacccgg gtcttcctga ccagccgaaa cgacgaagaa ttagacgaca caagtcaaag
      481 aagagtatta aaagcctcgg tggtgttacc gtaaggcaaa cggaactaga gacacagcga
      541 gagaaaacgc acccgccaca tccagatgcc cccgccatga gcagaaataa gaaaaggaag
      601 tggagggcaa agctgaggct gaggaggaag agagaagccg gcttagccgc cagggcctct
      661 gcggccagct tcacctacga gcccgagagc agcgaggagg cagaggtgga gggcgatgtg
      721 ggaggagagg aagaagagga tcccgagagc tcagttgcag accccgccca ggaagacact
      781 gagctcgcca gcagcagggc ggacagcctc ctgagttttc tgaagtcaac acaagaaatc
      841 tacttctacg atgcttccag agaggaccca gctgtgagca cagaagctgc tgaagagctg
      901 cttcgcctcc ttgagtctgg acgcttgcct cccgcagacg tgctcatcct ggaccacatg
      961 aaaaccctgc tgcttctgca ggacaccgag agactgacga gcgccctgaa gatgttcccc
     1021 gagcactgca tgatgcctcc agaccatgcc agaataatct cggctttctt taattattgg
     1081 atcacgcaga ttcttcctga aaaacgcagt gaataaatca ttgtcacctg agaagagctg
     1141 tcatttaaca cggagttatt aggtgcgcat aggatgcgaa ctgagactcc acgattgcac
     1201 ataaagagtt atttattatt tttattttcg gcgaatcaaa ccctggagac attgaagaca
     1261 tttctaccct gttatttatt tccgtgtttg tatgtcatag gtaaggtatc ctctgagact
     1321 ttaagtgaga aactggggta aaatgagagc atttacttgc ttaccgttac acgtacattg
     1381 atttacttca taaaactaga ttgtcttttg atgcctgtaa cagaaataga tattttatta
     1441 aataaactat atagtttgaa gtta
//
LOCUS       NM_001436575            6664 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus polypeptide
            N-acetylgalactosaminyltransferase-like 6 (Galntl6), transcript
            variant 2, mRNA.
ACCESSION   NM_001436575
VERSION     NM_001436575.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6664)
  AUTHORS   Zhang,S., Wang,X., Chen,G., Tong,L., Dai,T., Wang,L., Zhu,L.,
            Zhang,H. and Du,D.
  TITLE     CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced
            hypertension through upregulating Lig3 in rostral ventrolateral
            medulla
  JOURNAL   Redox Biol 64, 102782 (2023)
   PUBMED   37315345
  REMARK    GeneRIF: CircRNA Galntl6 sponges miR-335 to ameliorate
            stress-induced hypertension through upregulating Lig3 in rostral
            ventrolateral medulla.
REFERENCE   2  (bases 1 to 6664)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003. PMID: 25715345]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1695777.1,
                                           SRR26360176.61016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1957              JAXUCZ010000016.1  36203416-36205372
            1958-2066           JAXUCZ010000016.1  36643590-36643698
            2067-2205           JAXUCZ010000016.1  36732375-36732513
            2206-2372           JAXUCZ010000016.1  36772016-36772182
            2373-2558           JAXUCZ010000016.1  37231236-37231421
            2559-2742           JAXUCZ010000016.1  37235180-37235363
            2743-2860           JAXUCZ010000016.1  37313228-37313345
            2861-2968           JAXUCZ010000016.1  37354251-37354358
            2969-3190           JAXUCZ010000016.1  37384920-37385141
            3191-3307           JAXUCZ010000016.1  37424509-37424625
            3308-3457           JAXUCZ010000016.1  37434326-37434475
            3458-6664           JAXUCZ010000016.1  37451503-37454709
FEATURES             Location/Qualifiers
     source          1..6664
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12-p11"
     gene            1..6664
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="polypeptide N-acetylgalactosaminyltransferase-like
                     6"
                     /db_xref="GeneID:361142"
                     /db_xref="RGD:1564773"
     exon            1..1957
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1619..1621
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="upstream in-frame stop codon"
     CDS             1820..3625
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /EC_number="2.4.1.41"
                     /note="polypeptide N-acetylgalactosaminyltransferase 17;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 6"
                     /codon_start=1
                     /product="polypeptide
                     N-acetylgalactosaminyltransferase-like 6"
                     /protein_id="NP_001423504.1"
                     /db_xref="GeneID:361142"
                     /db_xref="RGD:1564773"
                     /translation="MKRKQKRFLQMTLLFTVALIFLPNIGLWSLYKDKHLMKSAEPAE
                     HQTFPLGLGDGQFYSWTDGLRRKDWHDYVSIQKDALRSGKGEHGKPYPLTEEDHDDSA
                     YRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTI
                     HSIINRTPESLIAEIILVDDFSDREHLKDKLEDYMARFPIVRIVRTKKREGLIRTRLL
                     GASVARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHSHFGYEAQAG
                     DAMRGAFDWEMYYKRIPIPPELQRADPSEPFESPVMAGGLFAVDRKWFWELGGYDPGL
                     EIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETW
                     MDEFAEYIYQRRPEYRHLSTGDISAQKELRKRLKCKDFKWFMAAVAWDVPKYYPPVEP
                     LPAAWGEIRNVAANLCVDSKHGAMGTELRLDICVKDGSERTWSHEQLFTFGWREDIRP
                     GEPLHTRKFCLDAISHSSPVTLYDCHGMKGNQLWGYREDRTLFHPVSNSCMDCNPAEK
                     KVFMARCDPLSETQQWMFEHINMTVLEKISHYAIS"
     misc_feature    2246..3133
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; Region: pp-GalNAc-T; cd02510"
                     /db_xref="CDD:133004"
     misc_feature    2246..3133
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; Region: pp-GalNAc-T; cd02510"
                     /db_xref="CDD:133004"
     misc_feature    order(2258..2266,2270..2272,2357..2359,2444..2446,
                     2453..2455,2465..2467,2513..2521,2759..2764,2828..2833,
                     2837..2839,2912..2914,2921..2923,2936..2938)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(2258..2266,2270..2272,2357..2359,2444..2446,
                     2453..2455,2465..2467,2513..2521,2759..2764,2828..2833,
                     2837..2839,2912..2914,2921..2923,2936..2938)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(2513..2515,2519..2521,2912..2914)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(2513..2515,2519..2521,2912..2914)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    3164..3601
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide
                     N-acetylgalactosaminyltransferase-like 6 (GALNTL6) and
                     similar proteins; Region: beta-trefoil_Ricin_GALNTL6;
                     cd23477"
                     /db_xref="CDD:467355"
     misc_feature    3164..3601
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide
                     N-acetylgalactosaminyltransferase-like 6 (GALNTL6) and
                     similar proteins; Region: beta-trefoil_Ricin_GALNTL6;
                     cd23477"
                     /db_xref="CDD:467355"
     misc_feature    order(3377..3379,3410..3412,3419..3421,3431..3436)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="putative sugar binding site [chemical binding];
                     other site"
                     /db_xref="CDD:467355"
     misc_feature    order(3377..3379,3410..3412,3419..3421,3431..3436)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="putative sugar binding site [chemical binding];
                     other site"
                     /db_xref="CDD:467355"
     exon            1958..2066
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2205
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2372
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2558
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2742
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2860
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2968
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3190
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3307
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3457
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..6664
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaccggc agacctctca gctataagca gcaggaggtg caggcatgct agggcgggga
       61 agcatcagtt agtgaagcca aagcttaacc tgggccccag gtgctggcgg actccagcgg
      121 agctgcctct gctctccact gtgttgtctg gaagctgcgg ctagcaaatc ggtccacgcg
      181 tggggatcct cttcctctct ccacgctacg tacctggctt gagctgtagg ttctggggga
      241 accctcctct cagggaccag tccagactgg gttgcctctg ctcactgtcg ctgccgctgc
      301 cgctgccgcg cctgcctcgc tgcgatctga tcaggaccat ggaggaattc ttccattgcc
      361 ctcccactcg gggcgactta gactctggaa tttctggcct ggcgcctttc gggtgagctc
      421 agagatgaac cggtctgcct accagttcga gattacccga gaagagagga tccgattgtc
      481 ccggagctgc aaatccattt ctccttctct gctttcatcc tcctttcctt ccccctagcc
      541 tccaggtttg tttatatagc acctggcagc cgggaggcag tggccactac cttcctgccg
      601 cggctcgccc acccctcccg gcctctaggc tcccgcacgt ggtagacacc agtatcgtcg
      661 ccagcaggca ggagacagcc agcgggaggc ggccgcctgg gtgccagctc cacgcgcgtt
      721 ctcgccatcc tcactcatcc tcagcgcgca ctctcccact tgcctgtaaa gccctgtcac
      781 acttgacatt cgccgcctgc catccgtccc ttgacgcgaa gtggagatcg gaaatacagc
      841 cctgggggtg ctggtgatgc ttcgctgggt tcgttcagtt gctggaaaag aatggtaaca
      901 tgaacagtgg agcgtgagag cgtcggcaca ggaaggggac tagattgatg ggcagagaac
      961 acacttctct gaggatctca ttcccaggac tgcgcgagga agggacatct ttgcgcctac
     1021 acttcctggc tggactctgc tgacatctgt agcctccttt ctgccaggtt cccaggtcgc
     1081 ctagatgctg cctgcagcgg agtgttctga cagcgcatga ggatccagga gtttgtgaac
     1141 ccctatccaa actagttctg acctggttat ggtgtccctg gatcctgagt gacaagctga
     1201 ctccagaggg agttgaactt gagttcaggt gggttatccc aaggcaagag aaggaaaagc
     1261 tgttctggga agataaggaa ggtgatgtgc caatgtcaaa agcggacact tttctttcag
     1321 acacttgatt ggaccaagcc actccctccc attcagttct tgcttttaat ctctgactct
     1381 acagcccgga cctcccacac taagggcggg ggatggtggg caaacagcga cagacaaaca
     1441 cctcctattt actgatctat ctagcatgct cttgacttcc tcataactta tcattattct
     1501 atgaaacgat cgtatttact ccagtgcttt atattaatgg aggtcaatag acttaatgat
     1561 ttcctcagtt gagtcgttta tttctaagcc aatagataat gcagtcgtca tagttttctg
     1621 agggaaagta actgtgcgtt tgttctgcag atggccaact ccctctgaac cctgcagatt
     1681 ggtgctgagc acacaacaaa agtttgtagc ttcccctcag tttctggtgc ttcccgggaa
     1741 agaggaaagg actttggcat taaacacaag aagcagtctg ggagtcatct ctaacttttc
     1801 tccactgtta tcatttgcaa tgaagaggaa acagaaaagg tttctgcaaa tgactttgtt
     1861 attcactgtg gctttaattt tcctgcccaa cattggtctc tggtctttgt acaaggataa
     1921 acatctgatg aaatctgcag aacccgcgga acatcagaca tttccactgg gcctaggcga
     1981 tgggcaattc tattcctgga cagatggtct gagaagaaaa gactggcatg actatgtgag
     2041 cattcagaaa gatgctttgc gctcagggaa aggtgagcat ggaaaaccat acccccttac
     2101 tgaagaggac catgatgact cagcttacag ggaaaatggc ttcaatattt ttgtcagcaa
     2161 caatattgct ctagagaggt ctctgccaga catccgccat gctaactgta agcacaagat
     2221 gtaccttgaa aggctgccaa acaccagcat cattatccca tttcacaatg aaggctggac
     2281 ctcactcttg cggaccatac acagtataat caaccggaca ccggagagtc tgatagcaga
     2341 aataattcta gtcgatgact tcagtgatag agaacacttg aaagataaat tagaagatta
     2401 catggctcga tttcccatag tgagaattgt gcgcaccaag aaaagggagg gactcatccg
     2461 gacccgactc ctgggagctt ctgtggccag aggcgaggtg ctgaccttcc tggactccca
     2521 ttgtgaggtc aatgtgaact ggctgccccc tctcctcaac caaattgcac taaaccacaa
     2581 aaccatcgtg tgtcccatga tcgatgtcat tgaccacagt cactttgggt acgaggcaca
     2641 agctggggat gccatgcgag gagccttcga ctgggaaatg tactacaaaa gaatccccat
     2701 ccctccagag ctccagcggg ctgatcccag cgagcctttt gagtctcctg ttatggctgg
     2761 aggtctcttt gcagtggatc gaaagtggtt ttgggaactg ggtggctatg acccaggctt
     2821 agaaatctgg ggaggagagc agtatgaaat ctcttttaag gtttggatgt gcggaggaga
     2881 aatgttcgat gttccatgtt ctagagtcgg tcatatctac aggaagtatg tcccttataa
     2941 agttccgtct gggactagcc tggcaaggaa cctgaagcgc gtggctgaga cctggatgga
     3001 tgaatttgct gagtacattt accagcggcg gccagagtac aggcacctct ccaccggaga
     3061 catctctgcc cagaaggagt tgcggaaacg acttaagtgc aaagacttca aatggttcat
     3121 ggctgcggtg gcctgggatg tgccgaagta ctaccctccg gtcgagcccc tgcctgcggc
     3181 atggggtgag attcgaaatg tggcagcaaa cttatgtgtg gatagcaagc atggagccat
     3241 ggggaccgaa ctgaggctgg acatctgtgt gaaggatggt tccgaaagga catggtctca
     3301 cgaacagctc tttactttcg ggtggagaga agatattcga cctggtgagc ctctgcacac
     3361 ccgaaaattc tgcttggatg ccatctcaca cagcagccct gtcaccctct acgactgtca
     3421 cggcatgaaa ggcaaccagc tctggggata ccgggaggac agaacattat tccatcccgt
     3481 gagcaacagc tgtatggact gcaaccctgc agagaagaag gttttcatgg ccagatgtga
     3541 ccctctgtcc gagactcagc agtggatgtt tgaacacatc aacatgactg ttttagaaaa
     3601 aattagccat tatgccatct cctagaaaag aaagaagagc gattacctac aggttgtgaa
     3661 ctgtgttgtt gcaggcatct ggatcaaagg agtcaggaat aacatttcct agatccagga
     3721 agcctggttg aaagacgtgt gaaggccatg ttgacgtagg ctgtccggga gaagttcctg
     3781 catctgaaga acttggctga gatcctcacc agctgcttct gagaactgag actagcagtt
     3841 cccttgctgg ccaagggtaa agattactta ggaactttca cctcgactgc tgagttaatc
     3901 aaccctagca tttctcaggt caaatcctgc agtagtgagt agctatgaat ggatcctatt
     3961 aatcgggtgg gaggggggtg gaaacagagc gcatgactgc tctggcaacc tgaggctacc
     4021 acaggtctag aactagccac gcttaagggg tgagctgtac tctttggtgc cattctctaa
     4081 gagtgggtta agcaggttta accctttcaa gtgctgcaga tgattttaga gtgctcatgc
     4141 catttttctc tttccttttg tcttctcttt aaacaagggt acatgacgtt gaaaacttac
     4201 actacatact ctcatctaca catactcttt tccttcaaag gcccatgtta tctgtcatgg
     4261 ttcattagag ctcatggttc accaattagc tgaagttcta atccagtgac cttagatgaa
     4321 tccagttaga aacaaaaaca gaccaacaaa acctatgcta ccaggttact ccaaagaaag
     4381 atttcacata agcaacaaaa tatcccaagc acccacacac atacacacac acacacacac
     4441 acacacacac acatacactc acacacactc acacacacgc acactcacac acacacacat
     4501 acacacatac actcacacac atacacatac agtcacacac acatacacac acacacaaca
     4561 tgcacacaag ttagggcaga aatttccctg ggaaatctat ttttactttt ctattatttt
     4621 taaataaaaa tctgatgttt gtccagtcat aatttttatt aaagaaggta ttggagtggg
     4681 ctccatgtaa tttgtttagt ctatcttaaa taaatcttca ctccaagtga tgtggaaatg
     4741 gcctcattca ctttaattct gtttaattgg ggaactttaa gagtggtgtt atttaatgat
     4801 tagttttgaa gcccctccct cttatggata ataatggtat tgttttattc agaagcccaa
     4861 aaagggatta catttctgat gccattttct gttaatggat aatatttcag gggtatcaaa
     4921 aagagaagta acttcaaaac taactaaatt agatatttaa accttaaaat aaattttccc
     4981 ttttccataa tgatggagtg aggagaagaa agtgcaggaa tgaagatcca tctttagagg
     5041 ggaaaaccac acttgctata tagtctctac ttgtgagtcc agcttgttcc tacattgctt
     5101 ttactgcctt ttgagatcgt ttccttgtta ataaaaatat atacattgag atgatctatg
     5161 tattttggac atagatcact gaagttccag gacaggaaga tgcagaagag tctacctttt
     5221 ctgttgttgt tcattttgtt tctcttgttt actctgtttt taaagtaagt atgaaaagtc
     5281 cagagaggcc cagcttctgg tgggctcatc acctggacgc ctcactcctg tccttccctc
     5341 agatgcccaa ttattcagaa gcctagtata tgacatatct tctagaaaat gtgcaagatc
     5401 attttctgtc ctctaaccct aatcaaaaca tacattagac gaccctgcta agaattgggg
     5461 aaggattacg tcagtatctt tactgataat tttttcaagc attcttccaa aaagctgttc
     5521 ttaaacagac tgtcactgag atcttttgtg tatgtcaagt gatcttgaca cagttaagat
     5581 gcatagtgga gaaaatcaat aatgagaaat tatcctgtgt gcagaacatc tctaaggagt
     5641 gaagaaggat ttatctcaga tgttccgaga ccaatctgac tggagacaca gatgattcta
     5701 taaaaactca cattatgtca ttaaacaatt gattgctact tacaattgta ccaaagacac
     5761 accctgggtt gcgcaccctg gaggcacaga tttgtagtaa tctcttagga tgcgatagtt
     5821 atggctaact caccaggccc taccctaagt gctacagcat tttagagagg tacacagtga
     5881 tcaatctata ttaaacagta tttaaaaaat atttttttct ttaaacacag aatgaaagct
     5941 tgggacatta aatccgaaat tgaaacttcg aactcggggc cagtcgttaa ttgtgtgcac
     6001 agtgggaatg tacggatgag gtggagcctg gggagtctgc ccctaggagg ggagggcaga
     6061 gccctgccca gtaaagcaca ttggaaaagg tgtttcctat accactggag ggcaagcttc
     6121 cacttgcttg aaatacacaa tctgaaaagc ataaaactat gtaggtttgc actttcaatt
     6181 agcaagaggg atagaagagt cctcagaaag actattgttc gtgggagtaa aattctttga
     6241 agagttcgat ggtagcgccc atatattctt tcctcagaat gaggggtgat ataaagttaa
     6301 tgcatcacag actttgctat ttctccatca taagagacag ttctggtgga agtaagagaa
     6361 taattaattt taaaaaccct ttcatgtatt tacagtggaa aaaaatgatg ctgtaacatg
     6421 atgtttcatg ttgggaacta agagtatgat tcatcctttt tcaaggctgg aggagaacct
     6481 tggcaataat gatataccgg cttctgtgtc tgctgttatt tacggatagg aattgaatca
     6541 catgactgtt tttaaatgta ttcattctat cagaagcccc agtgaataat gcaagctcta
     6601 ggactatttt gtgaattgat aacatagaac tttatacaat aaatgaataa cacataatgc
     6661 aaaa
//
LOCUS       NM_001436577            2501 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436577 XM_039094677
VERSION     NM_001436577.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2501)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2501)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2501)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2501)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_039094677.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2010387.1,
                                           SRR26360172.1484695.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000016.1  82902981-82903039   c
            60-134              JAXUCZ010000016.1  82902097-82902171   c
            135-201             JAXUCZ010000016.1  82885930-82885996   c
            202-308             JAXUCZ010000016.1  82877461-82877567   c
            309-430             JAXUCZ010000016.1  82872461-82872582   c
            431-740             JAXUCZ010000016.1  82871245-82871554   c
            741-809             JAXUCZ010000016.1  82870780-82870848   c
            810-961             JAXUCZ010000016.1  82869556-82869707   c
            962-1128            JAXUCZ010000016.1  82869032-82869198   c
            1129-1207           JAXUCZ010000016.1  82868362-82868440   c
            1208-2501           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2501
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..59
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..134
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    102..104
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     CDS             123..1355
                     /gene="Tfdp1"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 1"
                     /protein_id="NP_001423506.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGK
                     QLLPKTFGQSNVNITQQVVIGTPQRPAAANTIVVGSPHTPNTHFVSQNQTSDSSPWSA
                     GKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAY
                     DQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQ
                     KQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSI
                     SNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYV
                     TEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSY
                     VGEDDDDDDDFNENDEED"
     misc_feature    456..701
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    456..701
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(714..716,726..728,735..740,744..749,756..761,
                     765..770,777..782,789..791,798..803,810..812,819..824,
                     828..833,837..845,852..854,885..920,924..926,957..983,
                     987..989,993..995,999..1001,1017..1022,1026..1028)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(714..716,726..728,735..740,744..749,756..761,
                     765..770,777..782,789..791,798..803,810..812,819..824,
                     828..833,837..845,852..854,885..920,924..926,957..983,
                     987..989,993..995,999..1001,1017..1022,1026..1028)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    714..854
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    714..854
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    720..1136
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    720..1136
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(786..788,795..800,807..809,906..908,933..935,
                     939..941,984..1007,1026..1028)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(786..788,795..800,807..809,906..908,933..935,
                     939..941,984..1007,1026..1028)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            135..201
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..308
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..430
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..740
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..809
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..961
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1128
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1207
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2501
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccc acgtcaccgc gccgcgcgca cgtcacgccg gcccgacgct cggcccagga
       61 taagtccggt ttcttctgtg gagggtacgc agttaaagcc ttgatttcct ggatctggta
      121 acatggcaaa agatgccagt ctaattgaag ccaacggaga actaaaggtc tttatagacc
      181 agaatcttag tcctgggaaa ggtgtggtgt ctcttgtggc tgtgcaccca tccacagtga
      241 acacactggg gaagcagctt ttgccaaaaa ccttcggaca gtccaatgtc aatatcacac
      301 agcaagtggt gattggcacg cctcagagac ctgcagcagc caacactatt gtggtaggaa
      361 gcccacacac tcccaacact cactttgtgt cccagaacca gacgtctgac tcctcacctt
      421 ggtctgctgg gaagcggaac aggaaaggtg agaagaatgg caaaggcctg cggcatttct
      481 ccatgaaggt gtgtgagaag gtgcagagga aagggacgac ctcctacaat gaggtggccg
      541 acgagctggt tgccgagttc agcgccgctg acaaccacat cttacccaac gagtccgcct
      601 acgaccagaa gaacatccgg cggcgtgtgt acgatgcctt aaatgtgctg atggccatga
      661 acatcatctc caaggagaag aaggagatca agtggatcgg cctgcccacc aactctgctc
      721 aggagtgcca gaacttagag gtagagaggc agcggaggct ggagaggatc aaacaaaagc
      781 agtcacagct ccaggagctc atcctgcagc aaattgcctt caagaacttg gtgcagagaa
      841 atcgccaagc ggagcagcag gcccgcaggc caccgcctcc caactctgtc atccacttgc
      901 ccttcatcat tgtcaacacc agcaggaaga cagtcatcga ctgcagcatc tccaatgaca
      961 aatttgagta tctgttcaac tttgacaaca cgtttgaaat ccacgatgat atcgaggtgc
     1021 tcaagcgcat gggcatggcc tgtgggctgg agtcgggcag ctgctctgct gaagacctca
     1081 aggtggcgag aagtctggta ccaaaagctc tagaaccgta tgtgacagag atggctcagg
     1141 gatccattgg cggagtattt gtcacgacaa caggttctac atccaatggc acaaggcttt
     1201 ctgccagtga tttgagcaat ggtgcagatg ggatgctggc cacgagctcc aatgggtctc
     1261 agtacagcgg ctccagggtg gagacccctg tgtcctacgt tggggaggat gacgacgacg
     1321 acgatgactt taatgagaac gacgaggagg attgattact caactgtaga cccttctccc
     1381 ctcagtcagc ttcaggaaaa acgtatagag aaaagaagct tttgaagtgg ggctttccgt
     1441 tctttctggc ctactcccaa gaagatgccg ccgagttgtg gagttagata tgcagctcca
     1501 agtaaggagt gtgcccgcgg tgtgagcgag ctgtggatgt gtcgtgaagc cagcgtgcta
     1561 gagcagagcc tgtatctacc ttttaggatt ttatggttcc tctttctttc ttttttttgt
     1621 ttatcttctt tcctttcttt tttaagtttg aagcttgttt tgcccctcaa cagttgttgc
     1681 tggtttgctg aggaggctgt gctgcgcccc caccggtgac agtggtaaag cgctgcccgc
     1741 ctcgggtgtg cggcgcccag gtggtggaca gccaggcgtt aggatggatt ttcccatttg
     1801 tcaaatcatg cagagtccag agaacaaggc gatagcaaag ctccactgtt aacgctgcgc
     1861 gccatacgtc tcatgactgt ttttccttaa attatactga ctgtccagtt ccatcaatca
     1921 accttttctc aagcagcagc aaagcgagaa gtagtgtttc ttgtttgttt gttttgtttt
     1981 gtttggaaga agtttactgc cacgctggcg cagctatgga aattgtctag aaagtttgct
     2041 tatggtaaat ttgcctgatt tcttacaggc tacgtttgga aactttttat tatatagttt
     2101 acatacttat aagtctatca tttaaagacg tgtactgaaa caaatgttgt atttgtttca
     2161 taagcatctt cctgtaatct attataaaat tgaaattaaa catagagaat gttttaacag
     2221 ttttttaact caaaatttgt caatcatttt taatagttct ttttttataa aaagaaaaag
     2281 gaatttaagg acaggcaata gtctcttaaa atttattcac aagaaccgtt aactgcacag
     2341 ctgcccttag ctgcctgttc taaatgatgg tctttttatt gaaacacaaa taaacttttc
     2401 tgtaatattt tatggaatat aaagagactt taattgtttg acctgtttaa ctaagcactg
     2461 ttagttttta ttaataaaac gcgcatgggc attttaaaca a
//
LOCUS       NM_001436578            3068 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436578 XM_008771398
VERSION     NM_001436578.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_008771398.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.251770.1,
                                           SRR21887622.2734729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               JAXUCZ010000016.1  82902358-82902983   c
            627-701             JAXUCZ010000016.1  82902097-82902171   c
            702-768             JAXUCZ010000016.1  82885930-82885996   c
            769-875             JAXUCZ010000016.1  82877461-82877567   c
            876-997             JAXUCZ010000016.1  82872461-82872582   c
            998-1307            JAXUCZ010000016.1  82871245-82871554   c
            1308-1376           JAXUCZ010000016.1  82870780-82870848   c
            1377-1528           JAXUCZ010000016.1  82869556-82869707   c
            1529-1695           JAXUCZ010000016.1  82869032-82869198   c
            1696-1774           JAXUCZ010000016.1  82868362-82868440   c
            1775-3068           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..3068
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..626
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..701
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    669..671
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     CDS             690..1922
                     /gene="Tfdp1"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 1"
                     /protein_id="NP_001423507.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGK
                     QLLPKTFGQSNVNITQQVVIGTPQRPAAANTIVVGSPHTPNTHFVSQNQTSDSSPWSA
                     GKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAY
                     DQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQ
                     KQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSI
                     SNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYV
                     TEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSY
                     VGEDDDDDDDFNENDEED"
     misc_feature    1023..1268
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    1023..1268
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(1281..1283,1293..1295,1302..1307,1311..1316,
                     1323..1328,1332..1337,1344..1349,1356..1358,1365..1370,
                     1377..1379,1386..1391,1395..1400,1404..1412,1419..1421,
                     1452..1487,1491..1493,1524..1550,1554..1556,1560..1562,
                     1566..1568,1584..1589,1593..1595)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(1281..1283,1293..1295,1302..1307,1311..1316,
                     1323..1328,1332..1337,1344..1349,1356..1358,1365..1370,
                     1377..1379,1386..1391,1395..1400,1404..1412,1419..1421,
                     1452..1487,1491..1493,1524..1550,1554..1556,1560..1562,
                     1566..1568,1584..1589,1593..1595)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    1281..1421
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    1281..1421
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    1287..1703
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    1287..1703
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(1353..1355,1362..1367,1374..1376,1473..1475,
                     1500..1502,1506..1508,1551..1574,1593..1595)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(1353..1355,1362..1367,1374..1376,1473..1475,
                     1500..1502,1506..1508,1551..1574,1593..1595)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            702..768
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..997
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1307
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1376
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1528
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1695
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1774
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..3068
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtgagcc cgcgtcccgg cgccgctggc tcagggcagg gaccgccagg gccggacctc
       61 cgggccggcg cccccgcgcc cccgtcgtcc gccccgcgcg ccccgccggc cagccaggtg
      121 tggcgggggc accggccggt cgcggcggga gggcgcgggc tgggcgcgcg gccccgttcc
      181 cgccccagcc cggttcccgc gtccggtcgc atcccgcccg ccgcccagcc tcagcccgga
      241 gtcggcctcg acgcggcgtg gcgtgggcgg caggcagggg tcctggccac cctccggctc
      301 tgtccgcgcc agcgcgcgag gctggtggcc gggcctagtg acaggtgggg cggccgggcg
      361 gccgggagcc cacctgtcag agtggtcggc ggcacctcgg ggtcttgggc agccccgggg
      421 cctgctgcag cccgggcaga accacgcagt gtcgtgtgcc taagtggggg gccttgtgac
      481 tcggtggggc ctgtggtcag gcggggcccg cgtgcccagg tggggtgagc ctgacggctg
      541 cgcctcgctc cgccaagggg ccggggtctg gcccctctgc gggtgggagc tgctggtgcc
      601 cgcagggagc atttccattt ggagagataa gtccggtttc ttctgtggag ggtacgcagt
      661 taaagccttg atttcctgga tctggtaaca tggcaaaaga tgccagtcta attgaagcca
      721 acggagaact aaaggtcttt atagaccaga atcttagtcc tgggaaaggt gtggtgtctc
      781 ttgtggctgt gcacccatcc acagtgaaca cactggggaa gcagcttttg ccaaaaacct
      841 tcggacagtc caatgtcaat atcacacagc aagtggtgat tggcacgcct cagagacctg
      901 cagcagccaa cactattgtg gtaggaagcc cacacactcc caacactcac tttgtgtccc
      961 agaaccagac gtctgactcc tcaccttggt ctgctgggaa gcggaacagg aaaggtgaga
     1021 agaatggcaa aggcctgcgg catttctcca tgaaggtgtg tgagaaggtg cagaggaaag
     1081 ggacgacctc ctacaatgag gtggccgacg agctggttgc cgagttcagc gccgctgaca
     1141 accacatctt acccaacgag tccgcctacg accagaagaa catccggcgg cgtgtgtacg
     1201 atgccttaaa tgtgctgatg gccatgaaca tcatctccaa ggagaagaag gagatcaagt
     1261 ggatcggcct gcccaccaac tctgctcagg agtgccagaa cttagaggta gagaggcagc
     1321 ggaggctgga gaggatcaaa caaaagcagt cacagctcca ggagctcatc ctgcagcaaa
     1381 ttgccttcaa gaacttggtg cagagaaatc gccaagcgga gcagcaggcc cgcaggccac
     1441 cgcctcccaa ctctgtcatc cacttgccct tcatcattgt caacaccagc aggaagacag
     1501 tcatcgactg cagcatctcc aatgacaaat ttgagtatct gttcaacttt gacaacacgt
     1561 ttgaaatcca cgatgatatc gaggtgctca agcgcatggg catggcctgt gggctggagt
     1621 cgggcagctg ctctgctgaa gacctcaagg tggcgagaag tctggtacca aaagctctag
     1681 aaccgtatgt gacagagatg gctcagggat ccattggcgg agtatttgtc acgacaacag
     1741 gttctacatc caatggcaca aggctttctg ccagtgattt gagcaatggt gcagatggga
     1801 tgctggccac gagctccaat gggtctcagt acagcggctc cagggtggag acccctgtgt
     1861 cctacgttgg ggaggatgac gacgacgacg atgactttaa tgagaacgac gaggaggatt
     1921 gattactcaa ctgtagaccc ttctcccctc agtcagcttc aggaaaaacg tatagagaaa
     1981 agaagctttt gaagtggggc tttccgttct ttctggccta ctcccaagaa gatgccgccg
     2041 agttgtggag ttagatatgc agctccaagt aaggagtgtg cccgcggtgt gagcgagctg
     2101 tggatgtgtc gtgaagccag cgtgctagag cagagcctgt atctaccttt taggatttta
     2161 tggttcctct ttctttcttt tttttgttta tcttctttcc tttctttttt aagtttgaag
     2221 cttgttttgc ccctcaacag ttgttgctgg tttgctgagg aggctgtgct gcgcccccac
     2281 cggtgacagt ggtaaagcgc tgcccgcctc gggtgtgcgg cgcccaggtg gtggacagcc
     2341 aggcgttagg atggattttc ccatttgtca aatcatgcag agtccagaga acaaggcgat
     2401 agcaaagctc cactgttaac gctgcgcgcc atacgtctca tgactgtttt tccttaaatt
     2461 atactgactg tccagttcca tcaatcaacc ttttctcaag cagcagcaaa gcgagaagta
     2521 gtgtttcttg tttgtttgtt ttgttttgtt tggaagaagt ttactgccac gctggcgcag
     2581 ctatggaaat tgtctagaaa gtttgcttat ggtaaatttg cctgatttct tacaggctac
     2641 gtttggaaac tttttattat atagtttaca tacttataag tctatcattt aaagacgtgt
     2701 actgaaacaa atgttgtatt tgtttcataa gcatcttcct gtaatctatt ataaaattga
     2761 aattaaacat agagaatgtt ttaacagttt tttaactcaa aatttgtcaa tcatttttaa
     2821 tagttctttt tttataaaaa gaaaaaggaa tttaaggaca ggcaatagtc tcttaaaatt
     2881 tattcacaag aaccgttaac tgcacagctg cccttagctg cctgttctaa atgatggtct
     2941 ttttattgaa acacaaataa acttttctgt aatattttat ggaatataaa gagactttaa
     3001 ttgtttgacc tgtttaacta agcactgtta gtttttatta ataaaacgcg catgggcatt
     3061 ttaaacaa
//
LOCUS       NM_001436571            1467 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 5,
            mRNA.
ACCESSION   NM_001436571
VERSION     NM_001436571.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.743350.1,
                                           SRR26360181.878795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000016.1  82203615-82203756
            143-289             JAXUCZ010000016.1  82217914-82218060
            290-424             JAXUCZ010000016.1  82234137-82234271
            425-853             JAXUCZ010000016.1  82264721-82265149
            854-1045            JAXUCZ010000016.1  82268071-82268262
            1046-1467           JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1467
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..142
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            143..289
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            290..424
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            425..853
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1119
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 5 is encoded by transcript variant 5;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 5"
                     /protein_id="NP_001423500.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSRNKKRKWRAKLRLRRKREAGLAARASAASFTYEPESSEEAEV
                     EGDVGGEEEEDPESSVADPAQEDTELASSRADSLLSFLKSTQEIYFYDEASREDPAVS
                     TEAAEELLRLLESGRLPPADVLILDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHAR
                     IISAFFNYWITQILPEKRSE"
     exon            854..1045
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1467
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcagggt aggcaggaag cgcgaaacgc gaacggagac tggatctgag
      121 atagccaagg gtggcggacg tgtgtttact gagaaagtgc tgaagagact tttccctaac
      181 gtctcaagtg gtcaagaaaa gggcactccc cagactccag ctttggacac accatccaag
      241 gactcgaccc ctgaagcggt acagcagaag cccgttcgtg gtctgacagc tggtgacatt
      301 aagatccaac ctgagcgtcg cctctacacc gtgagtctgc ctcctccagg gtatatccct
      361 tgtttgccag aaccgaccag ctgtgcagat tccgaaaacg cctccagcgg tggtgacaca
      421 gaagacccgg gtcttcctga ccagccgaaa cgacgaagaa ttagacgaca caagtcaaag
      481 aagagtatta aaagcctcgg tggtgttacc gtaaggcaaa cggaactaga gacacagcga
      541 gagaaaacgc acccgccaca tccagatgcc cccgccatga gcagaaataa gaaaaggaag
      601 tggagggcaa agctgaggct gaggaggaag agagaagccg gcttagccgc cagggcctct
      661 gcggccagct tcacctacga gcccgagagc agcgaggagg cagaggtgga gggcgatgtg
      721 ggaggagagg aagaagagga tcccgagagc tcagttgcag accccgccca ggaagacact
      781 gagctcgcca gcagcagggc ggacagcctc ctgagttttc tgaagtcaac acaagaaatc
      841 tacttctacg atgaagcttc cagagaggac ccagctgtga gcacagaagc tgctgaagag
      901 ctgcttcgcc tccttgagtc tggacgcttg cctcccgcag acgtgctcat cctggaccac
      961 atgaaaaccc tgctgcttct gcaggacacc gagagactga cgagcgccct gaagatgttc
     1021 cccgagcact gcatgatgcc tccagaccat gccagaataa tctcggcttt ctttaattat
     1081 tggatcacgc agattcttcc tgaaaaacgc agtgaataaa tcattgtcac ctgagaagag
     1141 ctgtcattta acacggagtt attaggtgcg cataggatgc gaactgagac tccacgattg
     1201 cacataaaga gttatttatt atttttattt tcggcgaatc aaaccctgga gacattgaag
     1261 acatttctac cctgttattt atttccgtgt ttgtatgtca taggtaaggt atcctctgag
     1321 actttaagtg agaaactggg gtaaaatgag agcatttact tgcttaccgt tacacgtaca
     1381 ttgatttact tcataaaact agattgtctt ttgatgcctg taacagaaat agatatttta
     1441 ttaaataaac tatatagttt gaagtta
//
LOCUS       NM_001436565            3960 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus multifunctional ROCO family signaling regulator 1
            (Mfhas1), transcript variant 2, mRNA.
ACCESSION   NM_001436565 XM_006253227
VERSION     NM_001436565.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3960)
  AUTHORS   Wang,H.H., Sun,P.F., Chen,W.K., Zhong,J., Shi,Q.Q., Weng,M.L.,
            Ma,D. and Miao,C.H.
  TITLE     High Glucose Stimulates Expression of MFHAS1 to Mitigate
            Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein
            Endothelial Cells
  JOURNAL   Inflammation 41 (2), 400-408 (2018)
   PUBMED   29168081
REFERENCE   2  (bases 1 to 3960)
  AUTHORS   Shi,Q., Xiong,B., Zhong,J., Wang,H., Ma,D. and Miao,C.
  TITLE     MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C
            subunit cytoplasm translocation and inhibition of c-Jun
            dephosphorylation at Thr239
  JOURNAL   Mol Immunol 88, 79-88 (2017)
   PUBMED   28609714
REFERENCE   3  (bases 1 to 3960)
  AUTHORS   Zhong,J., Wang,H., Chen,W., Sun,Z., Chen,J., Xu,Y., Weng,M.,
            Shi,Q., Ma,D. and Miao,C.
  TITLE     Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1
            macrophage polarization by activating JNK and p38 pathways
  JOURNAL   Cell Death Dis 8 (5), e2763 (2017)
   PUBMED   28471450
  REMARK    Erratum:[Cell Death Dis. 2018 Jul 16;9(8):782. doi:
            10.1038/s41419-018-0828-y. PMID: 30013073]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3960)
  AUTHORS   Zhong,J., Shi,Q.Q., Zhu,M.M., Shen,J., Wang,H.H., Ma,D. and
            Miao,C.H.
  TITLE     MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB
            Signaling Pathway Following Negative Regulation
  JOURNAL   PLoS One 10 (11), e0143662 (2015)
   PUBMED   26599367
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3960)
  AUTHORS   Dihanich,S., Civiero,L., Manzoni,C., Mamais,A., Bandopadhyay,R.,
            Greggio,E. and Lewis,P.A.
  TITLE     GTP binding controls complex formation by the human ROCO protein
            MASL1
  JOURNAL   FEBS J 281 (1), 261-274 (2014)
   PUBMED   24286120
REFERENCE   6  (bases 1 to 3960)
  AUTHORS   Kumkhaek,C., Aerbajinai,W., Liu,W., Zhu,J., Uchida,N.,
            Kurlander,R., Hsieh,M.M., Tisdale,J.F. and Rodgers,G.P.
  TITLE     MASL1 induces erythroid differentiation in human
            erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK
            pathway
  JOURNAL   Blood 121 (16), 3216-3227 (2013)
   PUBMED   23327923
REFERENCE   7  (bases 1 to 3960)
  AUTHORS   Ng,A.C., Eisenberg,J.M., Heath,R.J., Huett,A., Robinson,C.M.,
            Nau,G.J. and Xavier,R.J.
  TITLE     Human leucine-rich repeat proteins: a genome-wide bioinformatic
            categorization and functional analysis in innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 108 Suppl 1 (Suppl 1), 4631-4638 (2011)
   PUBMED   20616063
REFERENCE   8  (bases 1 to 3960)
  AUTHORS   Sakabe,T., Shinomiya,T., Mori,T., Ariyama,Y., Fukuda,Y.,
            Fujiwara,T., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, MASL1, within an amplicon at 8p23.1
            detected in malignant fibrous histiocytomas by comparative genomic
            hybridization
  JOURNAL   Cancer Res 59 (3), 511-515 (1999)
   PUBMED   9973190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253227.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.52808.1,
                                           SRR26643297.47164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3588              JAXUCZ010000016.1  63333418-63337005   c
            3589-3960           JAXUCZ010000016.1  63324909-63325280   c
FEATURES             Location/Qualifiers
     source          1..3960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..3960
                     /gene="Mfhas1"
                     /note="multifunctional ROCO family signaling regulator 1"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
     exon            1..3588
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    576..578
                     /gene="Mfhas1"
                     /note="upstream in-frame stop codon"
     CDS             603..3617
                     /gene="Mfhas1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     malignant fibrous histiocytoma amplified sequence 1"
                     /codon_start=1
                     /product="malignant fibrous histiocytoma-amplified
                     sequence 1 isoform 2"
                     /protein_id="NP_001423494.1"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
                     /translation="MAGKDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDSL
                     ESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAV
                     AELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD
                     VSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPED
                     ISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNL
                     SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSI
                     VELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQ
                     KELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLG
                     SKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCF
                     PTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLS
                     HLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVS
                     CRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDS
                     ARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRD
                     ASLLLHKLLLGTNGEGEGEGESFPTIAVPTPGQDPLRATQLHHYVEGFLLHGLLPAHI
                     IRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPH
                     AEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFA
                     YRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGL
                     HYTVHILCSKCLKRGSPNPHAFPVNPRQSLRD"
     misc_feature    783..854
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    783..854
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    855..926
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    855..926
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <927..>1715
                     /gene="Mfhas1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <927..>1715
                     /gene="Mfhas1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    927..998
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    927..998
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    999..1067
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    999..1067
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1068..1136
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1068..1136
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1137..1274
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1137..1274
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1275..1343
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1275..1343
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1344..1412
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1344..1412
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1413..1481
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1413..1481
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1482..1550
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1482..1550
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1551..1619
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1551..1619
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1620..1682
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1620..1682
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1815..>2246
                     /gene="Mfhas1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    1815..>2246
                     /gene="Mfhas1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    1836..1859
                     /gene="Mfhas1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    1836..1859
                     /gene="Mfhas1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    1953..1955
                     /gene="Mfhas1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    1953..1955
                     /gene="Mfhas1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    1965..1973
                     /gene="Mfhas1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    1965..1973
                     /gene="Mfhas1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    2019..2030
                     /gene="Mfhas1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    2019..2030
                     /gene="Mfhas1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(2025..2030,2076..2081)
                     /gene="Mfhas1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(2025..2030,2076..2081)
                     /gene="Mfhas1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
     misc_feature    2199..2210
                     /gene="Mfhas1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    2199..2210
                     /gene="Mfhas1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    2568..3308
                     /gene="Mfhas1"
                     /note="C-terminal of Roc, COR, domain; Region: COR;
                     pfam16095"
                     /db_xref="CDD:406489"
     misc_feature    2568..3308
                     /gene="Mfhas1"
                     /note="C-terminal of Roc, COR, domain; Region: COR;
                     pfam16095"
                     /db_xref="CDD:406489"
     exon            3589..3960
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcttccc gatcgcgctc tcccagcgcc ggggacgcgg cgctcgcgct cccgcccgag
       61 ccgcggggaa acggagacaa ggagacgccg ccacctccgg cgccccggcc ctgctcccgc
      121 agcatgcccg ccgcggagcc gagcgccgcc ctcctcctgc agctagcgga ggcgacgccg
      181 ccggcctccg ggccgccgct gcgagggtag cggggccgga gtcggctact gaggcaaggc
      241 aaggcgggcg gagctggagg aggagcaggc atcctccgcg gcgcggcggg cggcggccct
      301 gctgcccggc gcgcccatgg cccgggagca cggagaatgc gagccgcgtt gcgcggccgc
      361 agccgagctc cgagccgctt gcccggagtc ccccaaagct gcctgcgtcg ctgccgctcc
      421 ccagctgcgg gctcccggcc actggctgtg ctaggaccca cagtcgccgg ccgcgcaggg
      481 gtggtggccc gggagcagcg ggagctagag ggcccgggag ctgggcgccg gccggagtcc
      541 agcgcggcat gcagctgcgg gctccggtac cggcgtgagg gttgtcggcg cgggctccgg
      601 ccatggctgg caaggacagt ggcaacctga agacggtgag gctgtggcgg gacgccgccc
      661 tgcgcgccag gaagctgcgg agcaacctgc gccagctcac gctcagctgc ccgggggcgg
      721 gaggcgactc actcgagtcc cccgacgccc cccagctggt gctgccggcc aacatcgggg
      781 acattgaggt gctgaacctg gggaacaacg gcctcgagga tgtgcctgaa ggtctggggt
      841 cagctctggg cagccttcgc gtcttggtct tgcgcaggaa ccgctttgcc cggctgcccc
      901 ctgcggtggc ggagctaggc caccacctta ccgaactgga cgtaagccac aaccggctaa
      961 ccatcctggg agccgaggtg gtgagcgccc taagggagct gcgcaaactc aacctgagcc
     1021 acaaccagct gccagccctg cctgcccagc tcggtgccct cgcccacctg gaggagctag
     1081 atgtcagctt caaccggcta gcgcatctgc cagattcctt ctcctgcctc aaccacctac
     1141 gtacccttga cgtggaccac aaccaactca ccgcctttcc ccagcagctg ctgcagctgg
     1201 ctgccctgga ggagctggac gtatccagca accggctgcg aggcctacct gaggatatca
     1261 gtgccctgcg tgccctcaag attctctggc ttagcggggc cgagcttggc actctgccca
     1321 gcggcttctg tgagctggcc agtttggaga gcctcatgtt agacaacaac gggctacagg
     1381 ctctgcccga cgagttcagc cgtctgcaaa ggctcaaaat gctcaacctt tcttccaacc
     1441 tcttcgagga gttccccgct gcgctgctgc ccctggctgg gctggaggag ctctacctta
     1501 gtcgcaatca gctcacctca gtgccctctc ttatcgccgg gctgggccgc cttctcacct
     1561 tgtggctgga taataaccgc atccgctacc tgccagactc cattgtggag ctgactggcc
     1621 tggaggagct ggtgcttcaa ggcaaccaga tcgctgttct gcctgacaac tttggccagc
     1681 tctcccgggt aggtttgtgg aaaatcaagg acaacccgct gattcagccc ccttacgaag
     1741 tctgcatgaa ggggatccct tatatcgcag cctaccagaa ggaactggct cattctcaac
     1801 cagcggttca gccccgtctc aagctgctcc tgatgggcca caaggctgcc ggaaagaccc
     1861 tgcttcgaca ctgcctcact gaggacaaag tggaaggagg gcaaggagga ggggacaagg
     1921 agaagagcta cctacctttc cctccccttg ggagtaaggg catcgaggtg accagctgga
     1981 ctgcggacgc ttcccggggc ttgcggttca ttgtgtatga cttagctggt gatgaaagct
     2041 acgaggtgat ccagcccttc ttcctctccc caggagccct atatgtgctc gtggtcaact
     2101 tggccaccta tgaacctcgt tgctttccta ctactgtggg ctccttcctg catcgggtgg
     2161 gggcccgtgt gcctcatgct gtggtgtgta ttgtgggcac acatgctgac ctgtgtgggg
     2221 agcgggagct tgaggagaag tgtctggata ttcaccgaca gattgccctg caggagaagc
     2281 atgatgcaga gggcctaagc catctagcca aggtggttga tgaggccctg gctcgggact
     2341 tcgagctacg ctctgccagt ccccatgcag cttactacgg tgtttcagac aagaaccttc
     2401 ggagacgcaa ggcccatttt cagtacctgc ttaaccaccg gctgcagatc ctctcgcccg
     2461 tgttgcctgt gagctgcagg gaccccctcc aactgcaacg ccttcgagac aagctgctct
     2521 ctgtagccga gcaccgggaa atctttccca acttacacag agtcctgcct cggtcctggc
     2581 aggtactgga ggagctgcac ttccagccac cccaggcaca acgtctgtgg ctaagctggt
     2641 gggactctgc ccgcttgggc ctgcaggcag gtctgactga ggaccggctc cagagtgccc
     2701 tttcttacct gcatgagagc ggcaaactgc tctattttga ggatagcccg gccctcaagg
     2761 agcacgtctt ccacaacctc acccgcctca ttgacatcct caatgttttt ttccagagag
     2821 atgcttcttt gctgcttcat aaactgctcc tagggaccaa cggagagggc gagggggagg
     2881 gggaaagttt ccccaccata gcagtgccca ctccgggcca ggacccactc cgggccaccc
     2941 agctccatca ttacgtggaa ggctttttgt tgcacgggct tctgccagct catatcattc
     3001 ggttgctgct caagcctcac gtccaggccc agcaggactt gcagctcctg ctggagctgc
     3061 tggagaagat gggactctgt tactgcctca ataaacccaa aggcaagcct ttgaacggct
     3121 ccgcagcttg gtacaagttc ccatgctacg tgcagaatga ggtgccccac gcggaggcct
     3181 ggattaatgg caccaaccta gccgggcagt cttttgtggc tgaacagttg cagatcgaat
     3241 acagttttcc ctttaccttc ccacctggat tgtttgcacg ttacagtgtt cagatcaaca
     3301 gccacgtggt gcacaggtcg gatgggaaat ttcagatctt tgcgtatcga gggaaagtgc
     3361 ccgtggtggt gagctacaga cctgccaagg gggtcctgca gccagacacc ctatccatcg
     3421 ccagccatgc gtcgctaccc aatatatgga ccgcatggca agccatcacc cctttggtag
     3481 aggaactgaa tgtcctactt caggaatggc ctggactaca ctacactgtg cacatcctct
     3541 gttctaagtg ccttaagaga gggtcgccaa atccacacgc tttcccagta aatcccaggc
     3601 agagcctgag ggactgatgg taccaccagc attgccagca ccgacaccag catcatcacc
     3661 gacttgctct gagacctttc aaagctaatc ctcccttttg agggagaaag cttccctttg
     3721 tcctaaggat cactgcggtc ttggttattt attcgctcct cctttggaag gatcaaggtc
     3781 atcaagtcat ttccagcttc cagagactat ggactgactc tgaagaagac agcaccaatt
     3841 agagtgggtg ttgccaagca tatgcgacta ccactggcag gtctctttgt cgagggaggc
     3901 tttgttgagg tgtttgccta ttattagcct attaaatgtt gagagattca aagagttaaa
//
LOCUS       NM_012988               9415 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor I/A (Nfia), transcript variant 2,
            mRNA.
ACCESSION   NM_012988 XM_346745
VERSION     NM_012988.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9415)
  AUTHORS   Ding,B., Wang,W., Selvakumar,T., Xi,H.S., Zhu,H., Chow,C.W.,
            Horton,J.D., Gronostajski,R.M. and Kilpatrick,D.L.
  TITLE     Temporal regulation of nuclear factor one occupancy by
            calcineurin/NFAT governs a voltage-sensitive developmental switch
            in late maturing neurons
  JOURNAL   J Neurosci 33 (7), 2860-2872 (2013)
   PUBMED   23407945
REFERENCE   2  (bases 1 to 9415)
  AUTHORS   Riffel,A.K., Schuenemann,E. and Vyhlidal,C.A.
  TITLE     Regulation of the CYP3A4 and CYP3A7 promoters by members of the
            nuclear factor I transcription factor family
  JOURNAL   Mol Pharmacol 76 (5), 1104-1114 (2009)
   PUBMED   19706729
REFERENCE   3  (bases 1 to 9415)
  AUTHORS   Royland,J.E. and Kodavanti,P.R.
  TITLE     Gene expression profiles following exposure to a developmental
            neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s)
            of action
  JOURNAL   Toxicol Appl Pharmacol 231 (2), 179-196 (2008)
   PUBMED   18602130
REFERENCE   4  (bases 1 to 9415)
  AUTHORS   Lu,W., Quintero-Rivera,F., Fan,Y., Alkuraya,F.S., Donovan,D.J.,
            Xi,Q., Turbe-Doan,A., Li,Q.G., Campbell,C.G., Shanske,A.L.,
            Sherr,E.H., Ahmad,A., Peters,R., Rilliet,B., Parvex,P.,
            Bassuk,A.G., Harris,D.J., Ferguson,H., Kelly,C., Walsh,C.A.,
            Gronostajski,R.M., Devriendt,K., Higgins,A., Ligon,A.H.,
            Quade,B.J., Morton,C.C., Gusella,J.F. and Maas,R.L.
  TITLE     NFIA haploinsufficiency is associated with a CNS malformation
            syndrome and urinary tract defects
  JOURNAL   PLoS Genet 3 (5), e80 (2007)
   PUBMED   17530927
REFERENCE   5  (bases 1 to 9415)
  AUTHORS   Lin,Y.L., Wang,Y.H. and Lee,H.J.
  TITLE     Transcriptional regulation of the human TR2 orphan receptor gene by
            nuclear factor 1-A
  JOURNAL   Biochem Biophys Res Commun 350 (2), 430-436 (2006)
   PUBMED   17010934
REFERENCE   6  (bases 1 to 9415)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   7  (bases 1 to 9415)
  AUTHORS   Osada,S., Daimon,S., Ikeda,T., Nishihara,T., Yano,K., Yamasaki,M.
            and Imagawa,M.
  TITLE     Nuclear factor 1 family proteins bind to the silencer element in
            the rat glutathione transferase P gene
  JOURNAL   J Biochem 121 (2), 355-363 (1997)
   PUBMED   9089412
REFERENCE   8  (bases 1 to 9415)
  AUTHORS   Monaci,P., Nuzzo,M., Stampfli,S., Tollervey,D., De Simone,V. and
            Nicosia,A.
  TITLE     A complex interplay of positive and negative elements is
            responsible for the different transcriptional activity of liver NF1
            variants
  JOURNAL   Mol Biol Rep 21 (3), 147-158 (1995)
   PUBMED   8832903
REFERENCE   9  (bases 1 to 9415)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   10 (bases 1 to 9415)
  AUTHORS   Paonessa,G., Gounari,F., Frank,R. and Cortese,R.
  TITLE     Purification of a NF1-like DNA-binding protein from rat liver and
            cloning of the corresponding cDNA
  JOURNAL   EMBO J 7 (10), 3115-3123 (1988)
   PUBMED   3053160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 17, 2025 this sequence version replaced NM_012988.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060652.1, D78017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               JAXUCZ010000005.1  117557078-117557461
            385-916             JAXUCZ010000005.1  117562518-117563049
            917-982             JAXUCZ010000005.1  117734267-117734332
            983-1057            JAXUCZ010000005.1  117778110-117778184
            1058-1175           JAXUCZ010000005.1  117792897-117793014
            1176-1303           JAXUCZ010000005.1  117799369-117799496
            1304-1432           JAXUCZ010000005.1  117820459-117820587
            1433-1611           JAXUCZ010000005.1  117842862-117843040
            1612-1777           JAXUCZ010000005.1  117845130-117845295
            1778-1869           JAXUCZ010000005.1  117860721-117860812
            1870-9415           JAXUCZ010000005.1  117889846-117897391
FEATURES             Location/Qualifiers
     source          1..9415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..9415
                     /gene="Nfia"
                     /note="nuclear factor I/A"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
     exon            1..384
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    262..264
                     /gene="Nfia"
                     /note="upstream in-frame stop codon"
     CDS             358..1887
                     /gene="Nfia"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear factor 1 A-type; CTF; NF1-A; NFI-A; NF-I/A;
                     nuclear factor 1/A; TGGCA-binding protein;
                     CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 A-type isoform 2"
                     /protein_id="NP_037120.1"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
                     /translation="MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKH
                     EKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPC
                     CVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPG
                     LCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFV
                     TSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTK
                     RLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSP
                     SPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHP
                     QETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVP
                     LPMPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYL
                     G"
     misc_feature    382..495
                     /gene="Nfia"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:463134"
     misc_feature    382..495
                     /gene="Nfia"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:463134"
     misc_feature    559..873
                     /gene="Nfia"
                     /note="MH1 domain; Region: MH1; pfam03165"
                     /db_xref="CDD:460833"
     misc_feature    559..873
                     /gene="Nfia"
                     /note="MH1 domain; Region: MH1; pfam03165"
                     /db_xref="CDD:460833"
     misc_feature    922..990
                     /gene="Nfia"
                     /note="propagated from UniProtKB/Swiss-Prot (P09414.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    997..1860
                     /gene="Nfia"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:459967"
     misc_feature    997..1860
                     /gene="Nfia"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:459967"
     misc_feature    1129..1131
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1132..1392
                     /gene="Nfia"
                     /note="propagated from UniProtKB/Swiss-Prot (P09414.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1150..1152
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12857; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1195..1197
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1216..1218
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1255..1257
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1270..1272
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1312..1314
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1411..1470
                     /gene="Nfia"
                     /note="propagated from UniProtKB/Swiss-Prot (P09414.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1435..1437
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12857; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1522..1524
                     /gene="Nfia"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q02780; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); methylation site"
     misc_feature    1537..1563
                     /gene="Nfia"
                     /note="propagated from UniProtKB/Swiss-Prot (P09414.2);
                     Region: 9aaTAD. /evidence=ECO:0000250|UniProtKB:Q12857"
     misc_feature    1666..1884
                     /gene="Nfia"
                     /note="propagated from UniProtKB/Swiss-Prot (P09414.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1762..1764
                     /gene="Nfia"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12857; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     misc_feature    1768..1770
                     /gene="Nfia"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12857; propagated from
                     UniProtKB/Swiss-Prot (P09414.2); phosphorylation site"
     exon            385..916
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            917..982
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1057
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1175
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1303
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1432
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1611
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1777
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1869
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..9415
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcggtgcg gtgcagaacg cggcgcaggc gggcgcgcgg gcagctcgcg ggcacccggc
       61 cggccggcgc gggagcggga aagggtgcgc tatgccttta acgcccgcgt acagtagaca
      121 gtatagtgga gtgtagggaa actctaggcg gggttaaagt tcagcgcgtg gagcggcaag
      181 agcgctggct gctgcagttg agccgagttg gaaatgtgaa cgcaagaagc aggcttgatt
      241 tttttttcct cccccctctc ctagctctct cctcctctct ctccctctcg cacccacact
      301 cacgcacacc tccagcccgc acacagacgt gcacgcaccc cccgccgccc ggcagttatg
      361 tattctccgc tctgtctcac ccaggatgag tttcatcctt tcattgaagc acttctgccc
      421 catgtccgcg ccttcgccta cacatggttc aacctgcagg cccgaaagcg gaaatacttc
      481 aaaaagcatg agaagcgcat gtcgaaagaa gaggagaggg ctgtgaagga tgaactgcta
      541 agtgagaagc ctgaggtcaa gcaaaagtgg gcttcccgac ttctggccaa gttacggaaa
      601 gatatccgac ccgagtaccg agaggatttt gttcttacag ttacagggaa aaaacctcca
      661 tgctgtgttc tttccaaccc agaccagaaa ggcaagatgc ggagaattga ctgcctccgc
      721 caggcagata aagtatggag gttggacctc gtcatggtga tcttgttcaa aggtattccg
      781 ctggaaagta ctgatggtga acgccttgtg aagtccccac agtgctcgaa tccagggctc
      841 tgtgtccagc cccatcacat aggggtttct gtaaaggaac tcgatttata tttggcatac
      901 tttgtacatg cagcagattc aagtcaatct gaaagtccca gccaaccaag tgatgctgac
      961 attaaggacc agccagaaaa tggacatttg ggcttccagg acagcttcgt cacatcaggt
     1021 gttttcagtg tgactgagct agtaagagtg tcacaaacac caatagctgc aggaaccggc
     1081 cccaattttt ctctctctga tttggaaagt tcctcatact acagcatgag tccaggagca
     1141 atgaggaggt ctctacccag cacatcctct accagctcta ccaagcgcct caagtctgtg
     1201 gaggacgaaa tggacagtcc tggtgaagaa ccattttaca caggccaagg gcgctcccca
     1261 gggagtggca gccagtccag cggatggcat gaagtagagc caggcatgcc atctccaacc
     1321 actctgaaga agtctgagaa gtctggtttc agcagcccct ccccttcgca gacctcctcc
     1381 ctcggaacag cattcacaca gcatcaccga cctgtcataa caggaccgag agcaagccca
     1441 catgcgacgc catcgactct ccactttcca acgtcaccta tcatccagca gcctgggcct
     1501 tatttctcac acccagccat ccgttaccac cctcaggaga cgctgaagga gtttgtccaa
     1561 cttgtctgcc ccgatgctgg tcagcaagct ggacaggtgg ggttcctcaa tcccaatgga
     1621 agcagtcaag gcaaggtgca caacccattc ctccccaccc caatgttgcc gccgccaccg
     1681 ccaccaccga tggccaggcc tgtgcctctg cccatgccag acaccaagcc tccaaccaca
     1741 tcaacagaag gcggtgcagc ctcccccacc tcaccgacct actcgacacc cagcacctcc
     1801 cccgcaaacc gattcgtcag tgttggacca cgggatccaa gctttgtaaa tatccctcaa
     1861 cagacacagt cctggtacct gggataaaag ttgcagcgtc ccaccatcct ccagacagac
     1921 cacctgaccc cttctcaact ctgtaacatg gacgcaacct caacccggcg cagttacaac
     1981 ttcactgtca gtggaagggg agagacacca actcgaatca acttgtacat ggaaacagcg
     2041 aacgtcgtgg tcaaacagca aaggccataa cttttcggga ttcttttttt ttttttaata
     2101 ctttagggac tgtcgtaatt tctcatatgg tgctggaaat ggttgggctg tgtgacattt
     2161 gaagtgttcc agtggtggtg tgagcagtag gtgaagcggc tggtagggga tgagccttgc
     2221 tcacgaactt cctgttgtaa cacttgtgag cctggccttt tcacagtatt tcaagaattt
     2281 gcccgcgcag gtgtgtgacc ctcccggagc acttggagac acctggagaa tgaaatcttt
     2341 cgtagtagct aagatctgtg atctgtaact tacaggacac tcaaagggca atgttttttg
     2401 ggttttcttt tttttctgta acatattaga aaaagcaaat gcagttaagt tgatctttct
     2461 tttagtttgg tttggttcag cagtcagcag ttaaatacat aacacaaccc tcaaggacag
     2521 tgaacccact catgttgcag agcaaatcca aaaagacagc aaagactact actactactc
     2581 tcagttcggt tgtttgtttt tttgttttgt tttgtttttt tattaagttt tgaaatgctg
     2641 cacttacatt taaaaaaaaa catttttcaa caatttcaac aatgacacaa aagttcacat
     2701 ggaaatgggg aagatggtct gttttgacag aaactgacag gaatcaaaac aatcgaattt
     2761 tgaattgagt gaagtgcaat ttcattggat agctaagtat ctttgtaaga tagagattgt
     2821 tgaaaattct atttttgttt ttcaagtcct cccaccccag gactctaaat tattggggtt
     2881 aaaaaaaaac agccttgcaa gaaaaagggg agctattttt gctttttatg ttttttattg
     2941 ttaaacttgt atccctttaa aaaaaaaaaa ccgaaggaaa atttaaaaaa aaaaacaaaa
     3001 aaaaaaatac aaatctaatg gtgcttttac cacaatatgt taactacatt aaatgctaat
     3061 taattatttt ctgttatcaa agcacataac tcaaatgaaa tcatggtatc tgttaatttt
     3121 ataagctaga aatcactata atgaattatg ccaattctgg aaaattttac acatgtatgg
     3181 caacaccaga tctatcggtt ttcaaacgcc tcgtcgtaac cagacattgt ccagaagttt
     3241 caaagaccct tcgcaaaccc tgaactgggc tacggggaaa taatactaac actgataagg
     3301 acataactgt gtgagcccat tcagatcaaa gtacttgtta gggaaaataa acaaacaaac
     3361 aaaaacaaaa tgttcacaca cacacacacc cccaaatgtc ttgtatctta tgtttaagga
     3421 aaaaagaaaa gacaaaaaaa aagacaaaaa aaaatcaaaa cagaaaaaaa agcagaaaca
     3481 aataaataaa caaaaaaaaa tgcaagtgat ttttctacca gacagcgaag cacccccttg
     3541 cttcccatgc gacttcacgg tttcctatac tatacgtata tatgtgttct ggtcggcagg
     3601 ccctgcccac cagaggaagt ctctgcatgt tctagtgtta gtaactaatt tttatatagc
     3661 taatgtagga taaagtagag tgcattaaga caatattgta accccagtct aggcacttgc
     3721 ctttaaactg tctcagccct tcagaagggc tcaactactg tcctatacaa tcaagtgact
     3781 gaaactcctg ggaagacact ttgctcctca tctaaccccc cccccaaaaa aacgatgttg
     3841 ttttgttttt atttttttcc ttaatttgca cgaaaacaga aattccatat caatgtgcct
     3901 tgccctggat agtgattttt ttgtggaatt gttgcacatg ctcctcaatt gaaggggttt
     3961 aatccctact caagcattcg gagacacttt ttgtaaatgt aacttttatg tcagccatcg
     4021 tcagtttcca catctagacc taaatagaga ggtagctgtt acgcagacag gcgtagtctc
     4081 ggttgtcctg tgtggtcagt ggcagtgcta ttctgagctc tgtagatgct tacaacgtca
     4141 gtatttggat gtcgctgcat tttttttttt caatttcttt ggagtcttcc tttgtccccg
     4201 cccccacccc acccccccca gatatatgaa aatatgcaat acctgcttat atcatgtaga
     4261 aaagcttagc aagtattaat ttttctttct ttcttttttt ttatttgacc aaagtcagtg
     4321 ctgcacatga cgcagtgggt tttaggtgtc tgtctttgtg ttttctgtgg tttctgatgc
     4381 acgtgtgcag gaagggctcc tcttagagaa gcagtcaaac tgtgaagcac taagctgacc
     4441 ctgcttcaag caattttgtt tttacaactg ttcctttcac aagcaagcct taaaaaaaaa
     4501 aaacaaaaaa caaaaaaaaa caaaaaacaa aaaaagacaa cttcctttct cttcagcccc
     4561 cacacccact tttcttagca gacggcagtc aatccacatt caataagaaa tacataatgc
     4621 ccatttttat atgcacgttt ttaaacttcc aagttctgaa aattgtttac tggttatctc
     4681 tatttaagga aaaaaaataa aataaaacat tttggatttt catatgtgtc tgataagtgg
     4741 ttgtatagtc gtttggcgct gttgtacggt gtgattatca gtgtacggtg tcacttccga
     4801 tagccagcag cagactttgc cttccctata gcacttagct gggcattact ttattatgac
     4861 atatgtgcac taaaagagag agagagagag agagagagag agagagagag agagagagag
     4921 agagagaaac atagcagctt tcagtgcttc acggtgaagg gaaaaaaaag cctagacaaa
     4981 cattttgtca gaaccttgca aaatgccaag gtattaccag taaattggtt gtatatacaa
     5041 taaaattgca cccttttttt aaacaaaacg aactaagcaa tagtttgggc agtcctagtt
     5101 gtttttagcg agcatgttgt agtcttgact gcaaagagag agaataagct gcccactcag
     5161 aagatatgta atttgtatcg ttgtatagtt ttattgatta cactgattta ttctacccta
     5221 ttttataatg caggactttt gtaatgttgt ctaaatgagg aaaaaaaatc tctgtcaaat
     5281 tagcctagtg aaatttccga ttgtccatta ccaaggcacc gttcatagca ttgatccttc
     5341 tttcttttcc tcctcctttg gaaactggat taagtttaaa actttcccgt ttccttttta
     5401 tttggttgtg ttgggttggt ttttttttta agtatttaaa tgcaattatt tttttctgcc
     5461 aatggtatca catattccta tgcttgagaa gtgtaggtct actgaaaaac cattgcaagt
     5521 ggacgttcca ggtgtgctgt acttttgaag gtattttgtt gtattaggtt taaaagtagg
     5581 gaactctgaa cagatttgca ggaacaaaag atgtttcaaa aggctctcga ccattgtgga
     5641 ggcagcgtgg ggtaacagca aacaagggtt aagtagaaaa tacactgagt tctgttctgt
     5701 tcatgcttca ttgtcaagac agcagcagaa aactgtatgg agttctgttg tcatcgagca
     5761 ggaaacaagg gatcaccgac caatgcattt taggttaaga gctgagccaa ggtgtttgag
     5821 gaagactttc ctacaggagt gtagagacag acagtcccaa gagctatcaa catttgaagg
     5881 cccagacttg attctgagac atgttggatt ttttttcccc tctcccatca aatggcatca
     5941 acacaattag caaagatagt ccctcaaatg actccttccc cccccatttt tgtctttggg
     6001 aactgaagtc agaggcacaa agactaactt tcagcatttt ccaataaatg ttctcccttg
     6061 gcccctctcc tggccaccac aaaactcctt tttctaaact gtcctgagca gaagtcttct
     6121 ctggtgccat tgtcctggtc ctccagccct tctctcccct ctaaggttat gtctcttcac
     6181 tgcctggcat gacatctata agctcactcc ccatacaggg ccaccaccac ccacatggac
     6241 tcccactggc cctctgggct caattctcca agcttccctt ctcctttccc ggcagtccaa
     6301 gagtgcagga tccaaatttc tagtcacgct gtgctatatt cagtcagccc acaagaatat
     6361 gcaaactcca tctcaaaaat attgtctttc accttcccaa atctttatcc tcgtgtgctt
     6421 caacctctgt agagcaatat catgaggtag ttgcaaagga aaacattttc tctcatgatt
     6481 tactttttgt tgttgttatt gttgttgggt tggaggggtt ttctttgttt gtttttcttt
     6541 ctttgggttt tgtttttgtt tttgatgggg tatggtcttt aagactgtca tttgacattt
     6601 ttacatcaga tcccatagtc cctgtctctt cctccttccc tccctgtctc cttctctgtt
     6661 tctttctgtc tgtgtatgtc tctctggttc ttctttgctt cttttcccct tctggtttct
     6721 ggtagcaggc ctccattgaa ctgttgtaaa acacaagaag tgtggtcagt aggagagttt
     6781 tggtggtgcc tcccagccta ctggccaaac catcctagac actcccagag gctgctccat
     6841 tcttgggcat ggctttcatt tacatgggct ttggaggcca ttttgtcttg aagtcaatgc
     6901 atgctctcat gctgttcgac agtaacctac tctgccttct ccacgtccaa ggctgtgcat
     6961 ttgtccaatt agtgtcatga atgtttcccc tttatttttt ccaataaaaa aagcagtggg
     7021 atgaaaattg ctttgatata tagcaggaat attgaagcta ttccatagca cttaaccgta
     7081 gtgaatactg tgtccccagt tctgaaatca atttaatgtt taatgcaaat ccattacatg
     7141 gtgctattac aggctgacaa aatgatttac acaaatgtga caactcgggc tcagttcact
     7201 ctgcttccca acagtgtaaa tgcatagcag tgtttatctg catgagaact atgcactaat
     7261 ctatctgaag aaaaaaaaaa actatatcaa ctttggtatc tactttccgt ttacttcaat
     7321 ccttgccttt ttggtcattg ttataatgcc agctttagga cagaaagaat tataagaaaa
     7381 ccagcataat acctgatata ttaaaatgta gtgcctgtga aacctgtatt atactgctct
     7441 tctgaagtaa gatttttcta caccggtagc cttcgctgtc tgtcagtcag gacctctggt
     7501 ataggtgatg taaaataacc gtacaatatt atgcatgcta tcccataatg cttagtgact
     7561 gtatgatatt actcagagtt ctgttagact tttttttctg cctcagttct tatcagctag
     7621 gtttgaggta tttcactgag aacgtgaact cggtcttcct tctggctgtc ttcatgatct
     7681 tggaggtgta cacttactta aattcagtat tacttgtgtt tgttttcatt tttgtttttt
     7741 tttttttttt gctttgtttt gttttgtttc tcctaaggga caagcatggg tgtttgattt
     7801 cagaaatcag tatatggtga gatttttgtc tcaaaactac catttgaatt tcaagaactc
     7861 tgctgcaaaa accagtctga gaatgtttcc aagtgagagt cactttgctg gccctcgaca
     7921 gaagctagac gacactgaag aaccttgaag gacagtgtac ccatgcttga tcagcctcac
     7981 tccagacttc ctcatagtaa aaaggaaaaa acaaaaaaat ttacaaaatc acgtagctat
     8041 ttagttacat gcacagatgc aatattttct tcaaaaatat aactctgtac aaacttcggg
     8101 cccgattcat aagaaagaag tttgctatta acacgggatt tttaaaatat gttctctctc
     8161 tctctctctc tctctctctc tctctctctc tctctctctc aatttaaatt tgaaactgtt
     8221 tgcttcccaa tttgaatatt tttctttaat ttcccccgaa ccagcaccca tctgcctttc
     8281 attctccaaa gggttgcatt aaggaagttg gagggatact atatggggac tggatcccag
     8341 tgacgaggct aagtgggaac tgtagggtag gaatataaca catggatgca ccccctctgt
     8401 gtgtcaggca tcctacatgt agactcactg tgctgtttgg gctgaaacat taactttgta
     8461 aaatgtgtct ggaccacaag agtatatagg agaagtgcta cctccgatct aactagagca
     8521 agttcatggc agaaagtatc acatacttta aaaatgtgaa gtttcccgtc tctccagtgg
     8581 tttccaaggc aagtggtgtc caagacacag accgttttca tgttgttcaa tgctcggctt
     8641 tgtaaaaagc ccaaagctat cttctctcgg ctttgactgc taattgtatt gctcttggtt
     8701 gtttttattt ttaaattttt ttcttggtaa tggtctgtaa atttgctttt tttttttaac
     8761 ctattattcc ccactaaagg tcttaggcat ctggccatgt caggatgcag tgagggagcc
     8821 gccagctttc ttctccctca gaccattgtc tctccactga actaggctgc ctccctaccg
     8881 aggtgccagc cagaggagtg ccagcaagtc ccagtaggtc cttaggaagg ctcccaaggc
     8941 caagtccgtg gttccttctc tgcttctccc acataccttt cccatcacac acgtcaaaca
     9001 tctgctcaga gtgcctctgt tctcttttca aattgggggg ggggattaaa aacttcaaat
     9061 gatggaaaaa acgagatctc ttgtgaaatg gaacgccccg tgttaataac ttggtctgaa
     9121 attgttttta tgagccgggc cccctgtgcc tctagcatat ttgtactgac tctcatagtt
     9181 acccttttcg tttactgtgt tctgtgaaaa cttgtaattg gttgagaatc actgtgggcg
     9241 tccattctta tcaactaagt ctccacaggg tttttgagct ggtgtggatt agtttaactc
     9301 ttgtattcaa ccgttagtgc taccaccttc tcacatcaca atacaattac tggaagcaag
     9361 tactgcattt cctatgcaac agaaaaggaa aaaataaaac aaattgctaa tgcta
//
LOCUS       NM_001025718            2434 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 5, mRNA.
ACCESSION   NM_001025718 XM_039094682 XM_573946
VERSION     NM_001025718.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2434)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2434)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2434)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2434)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 17, 2025 this sequence version replaced
            XM_039094682.2, NM_001025718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.245568.1,
                                           SRR26643296.35991.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000016.1  82902981-82903039   c
            60-134              JAXUCZ010000016.1  82902097-82902171   c
            135-241             JAXUCZ010000016.1  82877461-82877567   c
            242-363             JAXUCZ010000016.1  82872461-82872582   c
            364-673             JAXUCZ010000016.1  82871245-82871554   c
            674-742             JAXUCZ010000016.1  82870780-82870848   c
            743-894             JAXUCZ010000016.1  82869556-82869707   c
            895-1061            JAXUCZ010000016.1  82869032-82869198   c
            1062-1140           JAXUCZ010000016.1  82868362-82868440   c
            1141-2434           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2434
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..59
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..134
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     exon            135..241
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..363
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..673
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1288
                     /gene="Tfdp1"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 2"
                     /protein_id="NP_001020889.2"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKN
                     IRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQ
                     LQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDK
                     FEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYVTEMA
                     QGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGED
                     DDDDDDFNENDEED"
     misc_feature    416..634
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    416..634
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(647..649,659..661,668..673,677..682,689..694,
                     698..703,710..715,722..724,731..736,743..745,752..757,
                     761..766,770..778,785..787,818..853,857..859,890..916,
                     920..922,926..928,932..934,950..955,959..961)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(647..649,659..661,668..673,677..682,689..694,
                     698..703,710..715,722..724,731..736,743..745,752..757,
                     761..766,770..778,785..787,818..853,857..859,890..916,
                     920..922,926..928,932..934,950..955,959..961)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    647..787
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    647..787
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    653..1069
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    653..1069
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(719..721,728..733,740..742,839..841,866..868,
                     872..874,917..940,959..961)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(719..721,728..733,740..742,839..841,866..868,
                     872..874,917..940,959..961)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            674..742
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..894
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1061
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1140
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2434
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccc acgtcaccgc gccgcgcgca cgtcacgccg gcccgacgct cggcccagga
       61 taagtccggt ttcttctgtg gagggtacgc agttaaagcc ttgatttcct ggatctggta
      121 acatggcaaa agatgtgtgg tgtctcttgt ggctgtgcac ccatccacag tgaacacact
      181 ggggaagcag cttttgccaa aaaccttcgg acagtccaat gtcaatatca cacagcaagt
      241 ggtgattggc acgcctcaga gacctgcagc agccaacact attgtggtag gaagcccaca
      301 cactcccaac actcactttg tgtcccagaa ccagacgtct gactcctcac cttggtctgc
      361 tgggaagcgg aacaggaaag gtgagaagaa tggcaaaggc ctgcggcatt tctccatgaa
      421 ggtgtgtgag aaggtgcaga ggaaagggac gacctcctac aatgaggtgg ccgacgagct
      481 ggttgccgag ttcagcgccg ctgacaacca catcttaccc aacgagtccg cctacgacca
      541 gaagaacatc cggcggcgtg tgtacgatgc cttaaatgtg ctgatggcca tgaacatcat
      601 ctccaaggag aagaaggaga tcaagtggat cggcctgccc accaactctg ctcaggagtg
      661 ccagaactta gaggtagaga ggcagcggag gctggagagg atcaaacaaa agcagtcaca
      721 gctccaggag ctcatcctgc agcaaattgc cttcaagaac ttggtgcaga gaaatcgcca
      781 agcggagcag caggcccgca ggccaccgcc tcccaactct gtcatccact tgcccttcat
      841 cattgtcaac accagcagga agacagtcat cgactgcagc atctccaatg acaaatttga
      901 gtatctgttc aactttgaca acacgtttga aatccacgat gatatcgagg tgctcaagcg
      961 catgggcatg gcctgtgggc tggagtcggg cagctgctct gctgaagacc tcaaggtggc
     1021 gagaagtctg gtaccaaaag ctctagaacc gtatgtgaca gagatggctc agggatccat
     1081 tggcggagta tttgtcacga caacaggttc tacatccaat ggcacaaggc tttctgccag
     1141 tgatttgagc aatggtgcag atgggatgct ggccacgagc tccaatgggt ctcagtacag
     1201 cggctccagg gtggagaccc ctgtgtccta cgttggggag gatgacgacg acgacgatga
     1261 ctttaatgag aacgacgagg aggattgatt actcaactgt agacccttct cccctcagtc
     1321 agcttcagga aaaacgtata gagaaaagaa gcttttgaag tggggctttc cgttctttct
     1381 ggcctactcc caagaagatg ccgccgagtt gtggagttag atatgcagct ccaagtaagg
     1441 agtgtgcccg cggtgtgagc gagctgtgga tgtgtcgtga agccagcgtg ctagagcaga
     1501 gcctgtatct accttttagg attttatggt tcctctttct ttcttttttt tgtttatctt
     1561 ctttcctttc ttttttaagt ttgaagcttg ttttgcccct caacagttgt tgctggtttg
     1621 ctgaggaggc tgtgctgcgc ccccaccggt gacagtggta aagcgctgcc cgcctcgggt
     1681 gtgcggcgcc caggtggtgg acagccaggc gttaggatgg attttcccat ttgtcaaatc
     1741 atgcagagtc cagagaacaa ggcgatagca aagctccact gttaacgctg cgcgccatac
     1801 gtctcatgac tgtttttcct taaattatac tgactgtcca gttccatcaa tcaacctttt
     1861 ctcaagcagc agcaaagcga gaagtagtgt ttcttgtttg tttgttttgt tttgtttgga
     1921 agaagtttac tgccacgctg gcgcagctat ggaaattgtc tagaaagttt gcttatggta
     1981 aatttgcctg atttcttaca ggctacgttt ggaaactttt tattatatag tttacatact
     2041 tataagtcta tcatttaaag acgtgtactg aaacaaatgt tgtatttgtt tcataagcat
     2101 cttcctgtaa tctattataa aattgaaatt aaacatagag aatgttttaa cagtttttta
     2161 actcaaaatt tgtcaatcat ttttaatagt tcttttttta taaaaagaaa aaggaattta
     2221 aggacaggca atagtctctt aaaatttatt cacaagaacc gttaactgca cagctgccct
     2281 tagctgcctg ttctaaatga tggtcttttt attgaaacac aaataaactt ttctgtaata
     2341 ttttatggaa tataaagaga ctttaattgt ttgacctgtt taactaagca ctgttagttt
     2401 ttattaataa aacgcgcatg ggcattttaa acaa
//
LOCUS       NM_001436566            6788 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus kelch repeat and BTB domain containing 11
            (Kbtbd11), transcript variant 2, mRNA.
ACCESSION   NM_001436566 XM_006253390
VERSION     NM_001436566.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253390.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.72146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000016.1  81339607-81339818   c
            213-6788            JAXUCZ010000016.1  81318596-81325171   c
FEATURES             Location/Qualifiers
     source          1..6788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6788
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB domain containing 11"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
     exon            1..212
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     exon            213..6788
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    822..824
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="upstream in-frame stop codon"
     CDS             936..2837
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB (POZ) domain containing 11"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     11"
                     /protein_id="NP_001423495.1"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
                     /translation="MENSVAPFVLYPGTEPRTPGEDSLPLPAEEEGAASPAQTPCSLS
                     ASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPQECARP
                     EEPASPEEPPSRREHARPVELESLDELGEPVPVPPGVGSEHGEPDLVIEVAGRRLRAH
                     KAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGCMAGVRPDNVAEVVAGAR
                     RLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLSELRDAAYRFMCDHYLEVLREP
                     AVFGRLSGAERDLLLRRRLGTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVY
                     CYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFVAGGVAPAGPDGRARPSDQVFCYN
                     PVTDCWSTVRPLRQARSQVQLLALDGHLYALGGECLLSVERYDPRADRWTAVAPLPRG
                     AFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFL
                     YRFDLCGSRGDAQAATGSGGGVSVFRYHCLAKQWSQCAAHLRPPGAPAGLQPFRCVAL
                     DGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEK
                     PDRGEQGAA"
     misc_feature    1365..1673
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1365..1673
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1644..1874
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1644..1874
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1956..2657
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1956..2657
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    2001..2147
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2001..2147
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2157..2279
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2157..2279
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2421..2573
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2421..2573
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
ORIGIN      
        1 ggcgcgctcc cggcattggg aaagcgcgca gcatctcagc gctcgcacag gtgcgcggag
       61 ggttcgctcg ccccgggggc gctcccacag gtgcgcgcga atggtcgcgt gcgcatgcgt
      121 gtcagacccc cacgcccccc ggccaggctg cgagtcctgg gctccggtgg gttgcaggag
      181 tggagggaga gcgtcaggct gcgagcggtg aggagcaagg aggtggagag tgatgtgggg
      241 acctgacggg gaaggaagca gcggaggctc ccgatgacaa atgaggaaaa cctgggtaca
      301 cacacagacg cttcctttcc agccattcac ccataggtgg agtgcttccc taggtggaca
      361 gtgtgggtgg gaagctgcca cccagacaca catctcagct ggattctcgg ctgcacagcg
      421 ggagtctgta gaacagagcg gaagctaagg atttaagtgt ggccaccgcc cctggaagat
      481 ttgctggtcc tgggtctaca gtactgtgat aggaggtgac tcagtgggtc cacccagagt
      541 ccaaggacgc ccatgcttgt ggcccagaca cacttaacct cagttctcca aaggagcaat
      601 acaaaggagc ctcagctccg agcagtcgat gtgtaaactg caaaaaaaca aagcaaaaac
      661 caaacccctc tttgccacca ggctaattga cctccgcccc acggacgtag cctgagttga
      721 agttcccctt tcgaaagttc agtgagagtt ggggcgttga gaggagagtg ggaagggcaa
      781 ggtgggagtg gcgtgaacag ggggtggaca catgtgaaat ctgatccggt gccaaggaaa
      841 gggtttgtgc tgccagagac cccagggcaa agctctacct ccaccgggca tgtgtggctc
      901 ctgagctggc cgactgcaca cgacacaacc cactcatgga gaactcggtg gcgcctttcg
      961 tcctctaccc ggggactgag cccaggactc cgggagagga cagcctgcct ctgccagccg
     1021 aggaagaggg cgctgcatcc ccagcgcaga caccctgcag tctaagcgcc tcgctgtgtt
     1081 tcagctccgg ggacgactcc ccgccgcagt ctcgcgcctc tgccgcggag ggctccgaag
     1141 cttctccgcc ttctctccgc agcgacctgc gtgtggtgga gacgcagtgg gatgtcagca
     1201 gcgcggcgtc cccagagtcc ccacaggagt gcgcgcgccc ggaagagccc gcgtcgccgg
     1261 aggagccccc ttcccgccgc gagcacgcgc gtcccgtgga gctcgagtct ttagacgagc
     1321 ttggggagcc cgtgcctgtg ccgcccgggg tcgggtcaga gcacggagag cccgacttgg
     1381 tcatcgaggt ggcaggtcgc cggttgcggg ctcataaggc ggtgttggcg gcgcgcagcg
     1441 actacttccg cgcgcgtgcg tcgcgggacg tgctgcgggt gcaaggcgtg agcttcactg
     1501 ccctgcggct gctgctggcc gacgcgtaca gcgggtgcat ggccggcgtg cgaccggaca
     1561 acgtggccga ggtggtggcc ggcgcgcgcc gcctccagct gcccggcgct gcgcagcgcg
     1621 ccaccgaggc catggcgccg cagctgagcc tggacaactg ctacgaggtg ctgagcgcag
     1681 gcaagcggca gcggctgagc gagctgcgcg acgccgccta ccgcttcatg tgcgaccact
     1741 atctggaggt gctgcgcgag ccggccgtct tcggccgcct gtccggtgca gagcgtgatc
     1801 tgctgctgcg gcgccgcctg ggtacgggcc gcgcctgtct gctggccgct gccctgggga
     1861 caaccgggga gcgctcgggc agtcgaccgc agagtccgtc cggggacgca gagtcgcgcg
     1921 gggacgcagc ggtttattgc taccaggcgg aggccgggga gtggcgagag ctgactcggc
     1981 tgcccgaggg cgcgcccgcg cgcggctgcg gactctgcgt gctcttcaac tacctcttcg
     2041 tggcgggcgg tgtggctcct gcgggtccgg atggccgcgc gcgcccgtcg gaccaggtgt
     2101 tttgttacaa cccggtcacc gactgctgga gtactgtgcg acccctgcgc caggcgcgct
     2161 cgcaagtgca gctgctggct ctggacggcc acctatatgc cttgggcggc gagtgcctgc
     2221 tcagcgtgga gcgctatgac cctcgagctg accgctggac cgcggtggcc ccgcttcccc
     2281 ggggcgcctt cgcagtggcc cacgaggctg ccacctgtaa cggcgagatc tatgtgtccg
     2341 ggggctcact cttctaccgc ctgctcaagt acgatccccg gcgcgatgag tggcaggagt
     2401 gcccatgcag cagcagccga gagcgctctg ccgacatggt ggccctcgac ggtttcctct
     2461 atcgctttga cctgtgtggg agccgcggtg acgctcaggc tgcaactggt tcaggtggtg
     2521 gggtcagcgt gttccgctac cattgcctgg ccaagcagtg gagccagtgt gctgcacacc
     2581 tgcggccccc cggcgcaccc gcaggcctgc agccctttcg ttgtgttgcc ctggatggta
     2641 ccatctactg tgtgagccgc gctgggacct ggcgtttcgt gccttctcag gacactgagg
     2701 ctggcagcga tatgggaccc ggtggcagtt ttgaacctga gcccctggga tccccgctgg
     2761 atgtccgggg cgtactcttt ccatttgtgc tcaacctgcc tgagaagccg gaccgtgggg
     2821 aacagggtgc ggcctaggac aggatcagct gggcagctcc actgtccagc acttgtggtg
     2881 gtggggggct ccaaagaatg ggctgggccc cacccccagt aggggaggga gggcaaagag
     2941 gtctcaggaa tggaggacgc gcacaggcca ggctgctggc cacactgcat cgtgcaaacg
     3001 ctttgagagt agaagcttca actggcgctg aagacatttt tgcaatgctg ttttaagccc
     3061 cgctttgcag tgctggattc tgcttttgct tcgcttgttc gggggggggg ggtgtcatag
     3121 cttaaagtgt gggaagatag atacagagaa gcccatacct aagggaagaa gtagaggagg
     3181 ccaggataaa gtgggacgca ggtgcagact cgggtataat gaggaacctg cccagtcccc
     3241 tccttaccag cgagtgcaag gttctcaaac ctgaatgggg tcctaaagta ggccaggtat
     3301 ccttgcaaac cacagagaga cggtcaaacc ccgctctgag gtttaagtcg ataacttaga
     3361 agatctgcac gacctaacca ggacctaaaa agttcaccgt gtgttcgcaa gtaggttcaa
     3421 cttcaaacag taacttctca aatactgaag gcaaagggta gttgaccagt agagttgccg
     3481 ttgttgctga ctgaacggaa aagaacctca ggtcaggaga ccctggtagt tctgcatgtt
     3541 cacccccttt cccgtcttag aatgaaccag ggagattttt ttttccttcc tagaacagga
     3601 ggttaaaatc atgttttgac agttgcatgc tttgaaccct ctgctcggtt gttttgaacg
     3661 tatcttctgt gattctgaag agggagatta atttacaacc acctcaaaga aagtgtatgt
     3721 gtgtatgggg tggggggtga tatgctatgg aggaggaaaa ggagaaacgc accgttttga
     3781 gtgtagttta gcaagcaagt ggcattcatt taacttccta aacaccctac tcgagtccaa
     3841 aggagactca gacttaggtt gcaggaccaa aaccaagtcc gttcattttc tctcatgtgt
     3901 tgggctgttg tgcttttgag aatatacagg caaggatccc tgtttaaaga acagaatgtg
     3961 tgctcccagg taactggttt agattccata cctaaccctg ctgttttata acagtggggg
     4021 tcctaagtat tcatcgtttc tggaacataa gaggtagccc cgtgttcacc gtgccatctc
     4081 tgtagaaatc actggttagc tgagaaccag gctacacttt atagtctgtt ctgaaaggtc
     4141 acggtgaagt gtgtttagaa acagccagct tgaatcttct gcatgaccca ggggaatgga
     4201 gtttatagtt cctgtttgta tgttctggtc tctttgtgct tgttcgtggt tactcataaa
     4261 ccaagagaat gtcttggcca cttggttaat catcttaaga aaaacagact tcctattgcc
     4321 tggttttatt ggtccttttt gaggggcgtc ctggggaaag gcttgcagat gagccaaggg
     4381 agccggtgcc tagagacaca ccttcatcgc tgaagtacca gacttacaga atactgccac
     4441 gtgacgtttg cctaagaagc cgttcctctg acattcactt ttgaaattgg tcctctaggg
     4501 tgacatgtcc ccagagaggg cagatgtaca ccagacagga gagtcttcct gtgggcatag
     4561 tgccccacag agcacaaaca aaccccaagg aagtcaaaag gattaatgta cttacttgca
     4621 gatcgtgaaa ggacattagt tcgtcgatca cgaatagagg ccctgctttt tgagaactta
     4681 taaagtatct tgtgtcctgt ttataaacag tgacccccac tgaaaacaaa tgctacaggc
     4741 cttggcacat ctcagcaacc atgcattttg ttcctgggat ctggaagact tactacccat
     4801 ctgtcttaga ttcactttcc gtgataaaaa gcaacttaag ggagagaggt ttcattctgg
     4861 ctcagagttt gggttacagc ccttcatact gtggaagtcc cagggcaggg ctgtgagggg
     4921 gcgggtgctt ctgtacctgc agtcaagaca cagttaatgc atactgtcta tggtggtttg
     4981 catatgccct gccccaggga atggcactgt taggaggtgt ggccttgttg cagtgggtgt
     5041 gtcactgtgg tcgtgggctt aagaccctca tcctaactgc ctgggagcca gccttcttct
     5101 agcagccttc agatgaagat gtagaactct cagctcctcc tgcaccatgc ctgcctggat
     5161 gctgctgtgt tcccaccttg atgataatgg actgactttc tgaacctgaa agccagcccc
     5221 aattcaatgc tgtcctaata agagttgcct tggtcgtggc gtctgttcac agcagtaaaa
     5281 ccctaactga gacaccgact ccactcagct gtctccacgc atacattccc aggacccggt
     5341 tagaaaatgc tgccacccat aggaagaagc tcttttcatt ccaattaatg taatcaagtt
     5401 aactccccac agacgtgctt agcagcccaa ctcccaggtg actctagatt ctgttcacag
     5461 caacctgcac gcccacagca agtgttggta ttggtttggt agtgagggta gcggggtttg
     5521 agaaggatgt gtctccagtg tgtgaaccag gtaggtgctt tctccatgct ggtctcattc
     5581 cgcctccaac tccacctggg agtttggtcg gtgtcagcac agatctgact atcagctaag
     5641 agtcaaataa ggctacgatg cctggaacac ccagcctcag ctcttaggac attaaccctt
     5701 gtacacagac accctgagtg tttgaaggga cagcactctt aaggagtaaa tgattgatac
     5761 actaagattg accttctgtt tggttgatgg gtaactgcat ttatatctcc aaggtttgtt
     5821 tggaatctta gcaacgagct gatgtttctg gatttttctt ttctttctgt tttgtacttt
     5881 ggcatggggc gagccccacc tctagggcag acacttggca tctcggcaga cttggaatgt
     5941 ggtgattctg cttctgagga aatgacggca ggagtttctt ttactctaag gaaaatgaac
     6001 gttgtggaaa tcttgttggc tgcttagtgt cttacgtgtt ttctgttttt gctgcacaag
     6061 caaagaaagg aaaaagaaca gggtccctct agccctggtg ggtgaccgtg tgactgcact
     6121 ttgtccagtg ttggaactga gggcctctga gggtgtgctg ctctctgctg aagtcaagat
     6181 agagtcagga catgatggtt tggaacgttt cagtggcaga tgtgagccca atagctcttt
     6241 ggtgtagtgt ttcactttag gggccctccc tagcttgcag aaagtcttca ttttgatact
     6301 tggttttgtt ttgttttatg tccccatttt ttctgtaata ttattcacaa gaaggtaatg
     6361 actccagctg aaagtggaac tctgccagca ctctctgcct ctgtgtttat ccaagcagac
     6421 atgtcaggga tgctctgccc acatccatga agagggcagc accgtgagat gctgagggat
     6481 ctggcaggaa gtgggtcctg gcagcagctt cacctggctt tgtggccagg tttgggtgtc
     6541 tgcgtattcc aatgtgaggt tgctctcccc cgccccgtca tgcttcgtag agctttgact
     6601 agtacctact actaactagt atgtacccgt ggccatttac taaagatccc tacctgtctg
     6661 aggcaaagtc gggccagctg tctgtcactg tgctccacac ttgagttttt accctaggca
     6721 taaatgctct aaaaccttgt atgtttgtca cctgtgccaa gacgaaataa actatgtgga
     6781 aactccca
//
LOCUS       NM_001436579            2675 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 4, mRNA.
ACCESSION   NM_001436579 XM_008771397
VERSION     NM_001436579.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2675)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2675)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2675)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2675)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2675)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2675)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2675)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2675)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2675)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2675)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_008771397.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.75890.1,
                                           SRR26643297.47641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000016.1  82902640-82902872   c
            234-308             JAXUCZ010000016.1  82902097-82902171   c
            309-375             JAXUCZ010000016.1  82885930-82885996   c
            376-482             JAXUCZ010000016.1  82877461-82877567   c
            483-604             JAXUCZ010000016.1  82872461-82872582   c
            605-914             JAXUCZ010000016.1  82871245-82871554   c
            915-983             JAXUCZ010000016.1  82870780-82870848   c
            984-1135            JAXUCZ010000016.1  82869556-82869707   c
            1136-1302           JAXUCZ010000016.1  82869032-82869198   c
            1303-1381           JAXUCZ010000016.1  82868362-82868440   c
            1382-2675           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2675
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..233
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..308
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    276..278
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     CDS             297..1529
                     /gene="Tfdp1"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 1"
                     /protein_id="NP_001423508.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGK
                     QLLPKTFGQSNVNITQQVVIGTPQRPAAANTIVVGSPHTPNTHFVSQNQTSDSSPWSA
                     GKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAY
                     DQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQ
                     KQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSI
                     SNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYV
                     TEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSY
                     VGEDDDDDDDFNENDEED"
     misc_feature    630..875
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    630..875
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(888..890,900..902,909..914,918..923,930..935,
                     939..944,951..956,963..965,972..977,984..986,993..998,
                     1002..1007,1011..1019,1026..1028,1059..1094,1098..1100,
                     1131..1157,1161..1163,1167..1169,1173..1175,1191..1196,
                     1200..1202)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(888..890,900..902,909..914,918..923,930..935,
                     939..944,951..956,963..965,972..977,984..986,993..998,
                     1002..1007,1011..1019,1026..1028,1059..1094,1098..1100,
                     1131..1157,1161..1163,1167..1169,1173..1175,1191..1196,
                     1200..1202)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    888..1028
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    888..1028
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    894..1310
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    894..1310
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(960..962,969..974,981..983,1080..1082,1107..1109,
                     1113..1115,1158..1181,1200..1202)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(960..962,969..974,981..983,1080..1082,1107..1109,
                     1113..1115,1158..1181,1200..1202)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            309..375
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..482
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..604
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..914
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..983
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1135
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1302
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1381
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2675
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaggtgt ggcgggggca ccggccggtc gcggcgggag ggcgcgggct gggcgcgcgg
       61 ccccgttccc gccccagccc ggttcccgcg tccggtcgca tcccgcccgc cgcccagcct
      121 cagcccggag tcggcctcga cgcggcgtgg cgtgggcggc aggcaggggt cctggccacc
      181 ctccggctct gtccgcgcca gcgcgcgagg ctggtggccg ggcctagtga cagataagtc
      241 cggtttcttc tgtggagggt acgcagttaa agccttgatt tcctggatct ggtaacatgg
      301 caaaagatgc cagtctaatt gaagccaacg gagaactaaa ggtctttata gaccagaatc
      361 ttagtcctgg gaaaggtgtg gtgtctcttg tggctgtgca cccatccaca gtgaacacac
      421 tggggaagca gcttttgcca aaaaccttcg gacagtccaa tgtcaatatc acacagcaag
      481 tggtgattgg cacgcctcag agacctgcag cagccaacac tattgtggta ggaagcccac
      541 acactcccaa cactcacttt gtgtcccaga accagacgtc tgactcctca ccttggtctg
      601 ctgggaagcg gaacaggaaa ggtgagaaga atggcaaagg cctgcggcat ttctccatga
      661 aggtgtgtga gaaggtgcag aggaaaggga cgacctccta caatgaggtg gccgacgagc
      721 tggttgccga gttcagcgcc gctgacaacc acatcttacc caacgagtcc gcctacgacc
      781 agaagaacat ccggcggcgt gtgtacgatg ccttaaatgt gctgatggcc atgaacatca
      841 tctccaagga gaagaaggag atcaagtgga tcggcctgcc caccaactct gctcaggagt
      901 gccagaactt agaggtagag aggcagcgga ggctggagag gatcaaacaa aagcagtcac
      961 agctccagga gctcatcctg cagcaaattg ccttcaagaa cttggtgcag agaaatcgcc
     1021 aagcggagca gcaggcccgc aggccaccgc ctcccaactc tgtcatccac ttgcccttca
     1081 tcattgtcaa caccagcagg aagacagtca tcgactgcag catctccaat gacaaatttg
     1141 agtatctgtt caactttgac aacacgtttg aaatccacga tgatatcgag gtgctcaagc
     1201 gcatgggcat ggcctgtggg ctggagtcgg gcagctgctc tgctgaagac ctcaaggtgg
     1261 cgagaagtct ggtaccaaaa gctctagaac cgtatgtgac agagatggct cagggatcca
     1321 ttggcggagt atttgtcacg acaacaggtt ctacatccaa tggcacaagg ctttctgcca
     1381 gtgatttgag caatggtgca gatgggatgc tggccacgag ctccaatggg tctcagtaca
     1441 gcggctccag ggtggagacc cctgtgtcct acgttgggga ggatgacgac gacgacgatg
     1501 actttaatga gaacgacgag gaggattgat tactcaactg tagacccttc tcccctcagt
     1561 cagcttcagg aaaaacgtat agagaaaaga agcttttgaa gtggggcttt ccgttctttc
     1621 tggcctactc ccaagaagat gccgccgagt tgtggagtta gatatgcagc tccaagtaag
     1681 gagtgtgccc gcggtgtgag cgagctgtgg atgtgtcgtg aagccagcgt gctagagcag
     1741 agcctgtatc taccttttag gattttatgg ttcctctttc tttctttttt ttgtttatct
     1801 tctttccttt cttttttaag tttgaagctt gttttgcccc tcaacagttg ttgctggttt
     1861 gctgaggagg ctgtgctgcg cccccaccgg tgacagtggt aaagcgctgc ccgcctcggg
     1921 tgtgcggcgc ccaggtggtg gacagccagg cgttaggatg gattttccca tttgtcaaat
     1981 catgcagagt ccagagaaca aggcgatagc aaagctccac tgttaacgct gcgcgccata
     2041 cgtctcatga ctgtttttcc ttaaattata ctgactgtcc agttccatca atcaaccttt
     2101 tctcaagcag cagcaaagcg agaagtagtg tttcttgttt gtttgttttg ttttgtttgg
     2161 aagaagttta ctgccacgct ggcgcagcta tggaaattgt ctagaaagtt tgcttatggt
     2221 aaatttgcct gatttcttac aggctacgtt tggaaacttt ttattatata gtttacatac
     2281 ttataagtct atcatttaaa gacgtgtact gaaacaaatg ttgtatttgt ttcataagca
     2341 tcttcctgta atctattata aaattgaaat taaacataga gaatgtttta acagtttttt
     2401 aactcaaaat ttgtcaatca tttttaatag ttcttttttt ataaaaagaa aaaggaattt
     2461 aaggacaggc aatagtctct taaaatttat tcacaagaac cgttaactgc acagctgccc
     2521 ttagctgcct gttctaaatg atggtctttt tattgaaaca caaataaact tttctgtaat
     2581 attttatgga atataaagag actttaattg tttgacctgt ttaactaagc actgttagtt
     2641 tttattaata aaacgcgcat gggcatttta aacaa
//
LOCUS       NM_001436572            1593 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 6,
            mRNA.
ACCESSION   NM_001436572 XM_039094600
VERSION     NM_001436572.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_039094600.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.361824.1,
                                           SRR26360194.1745055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680453, SAMN16093045
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000016.1  82203615-82203756
            143-268             JAXUCZ010000016.1  82217625-82217750
            269-415             JAXUCZ010000016.1  82217914-82218060
            416-550             JAXUCZ010000016.1  82234137-82234271
            551-979             JAXUCZ010000016.1  82264721-82265149
            980-1171            JAXUCZ010000016.1  82268071-82268262
            1172-1593           JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1593
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..142
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            143..268
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    253..255
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="upstream in-frame stop codon"
     exon            269..415
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            416..550
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            551..979
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             703..1245
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 5 is encoded by transcript variant 6;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 5"
                     /protein_id="NP_001423501.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSRNKKRKWRAKLRLRRKREAGLAARASAASFTYEPESSEEAEV
                     EGDVGGEEEEDPESSVADPAQEDTELASSRADSLLSFLKSTQEIYFYDEASREDPAVS
                     TEAAEELLRLLESGRLPPADVLILDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHAR
                     IISAFFNYWITQILPEKRSE"
     exon            980..1171
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1593
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcagggt aggcaggaag cgcgaaacgc gaacggagac tggatctgag
      121 atagccaagg gtggcggacg tgctggtcta ggatcctgcc ctgtctgcga gtccacgcct
      181 tctgaaggcc aaacacagag gtgatcgtcc tcttagtgtg gggccatgga gcagcgtcca
      241 tgggcgtcca tttgaagtgt gggctctgtg tttactgaga aagtgctgaa gagacttttc
      301 cctaacgtct caagtggtca agaaaagggc actccccaga ctccagcttt ggacacacca
      361 tccaaggact cgacccctga agcggtacag cagaagcccg ttcgtggtct gacagctggt
      421 gacattaaga tccaacctga gcgtcgcctc tacaccgtga gtctgcctcc tccagggtat
      481 atcccttgtt tgccagaacc gaccagctgt gcagattccg aaaacgcctc cagcggtggt
      541 gacacagaag acccgggtct tcctgaccag ccgaaacgac gaagaattag acgacacaag
      601 tcaaagaaga gtattaaaag cctcggtggt gttaccgtaa ggcaaacgga actagagaca
      661 cagcgagaga aaacgcaccc gccacatcca gatgcccccg ccatgagcag aaataagaaa
      721 aggaagtgga gggcaaagct gaggctgagg aggaagagag aagccggctt agccgccagg
      781 gcctctgcgg ccagcttcac ctacgagccc gagagcagcg aggaggcaga ggtggagggc
      841 gatgtgggag gagaggaaga agaggatccc gagagctcag ttgcagaccc cgcccaggaa
      901 gacactgagc tcgccagcag cagggcggac agcctcctga gttttctgaa gtcaacacaa
      961 gaaatctact tctacgatga agcttccaga gaggacccag ctgtgagcac agaagctgct
     1021 gaagagctgc ttcgcctcct tgagtctgga cgcttgcctc ccgcagacgt gctcatcctg
     1081 gaccacatga aaaccctgct gcttctgcag gacaccgaga gactgacgag cgccctgaag
     1141 atgttccccg agcactgcat gatgcctcca gaccatgcca gaataatctc ggctttcttt
     1201 aattattgga tcacgcagat tcttcctgaa aaacgcagtg aataaatcat tgtcacctga
     1261 gaagagctgt catttaacac ggagttatta ggtgcgcata ggatgcgaac tgagactcca
     1321 cgattgcaca taaagagtta tttattattt ttattttcgg cgaatcaaac cctggagaca
     1381 ttgaagacat ttctaccctg ttatttattt ccgtgtttgt atgtcatagg taaggtatcc
     1441 tctgagactt taagtgagaa actggggtaa aatgagagca tttacttgct taccgttaca
     1501 cgtacattga tttacttcat aaaactagat tgtcttttga tgcctgtaac agaaatagat
     1561 attttattaa ataaactata tagtttgaag tta
//
LOCUS       NM_001436570             974 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 4,
            mRNA.
ACCESSION   NM_001436570 XM_039094598
VERSION     NM_001436570.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_039094598.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2256693.1,
                                           SRR26360181.1637277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  82203615-82203692
            79-225              JAXUCZ010000016.1  82217914-82218060
            226-360             JAXUCZ010000016.1  82234137-82234271
            361-552             JAXUCZ010000016.1  82268071-82268262
            553-974             JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..974
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..78
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..626
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 4 is encoded by transcript variant 4;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 4"
                     /protein_id="NP_001423499.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSSLRKQVFTEKVLKRLFPNVSSGQEKGTPQTPALDTPSKDSTP
                     EAVQQKPVRGLTAGDIKIQPERRLYTVSLPPPGYIPCLPEPTSCADSENASSGGDTEE
                     ASREDPAVSTEAAEELLRLLESGRLPPADVLILDHMKTLLLLQDTERLTSALKMFPEH
                     CMMPPDHARIISAFFNYWITQILPEKRSE"
     misc_feature    <366..>572
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     misc_feature    <366..>572
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     exon            79..225
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            226..360
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            361..552
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            553..974
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcaggtg tttactgaga aagtgctgaa gagacttttc cctaacgtct
      121 caagtggtca agaaaagggc actccccaga ctccagcttt ggacacacca tccaaggact
      181 cgacccctga agcggtacag cagaagcccg ttcgtggtct gacagctggt gacattaaga
      241 tccaacctga gcgtcgcctc tacaccgtga gtctgcctcc tccagggtat atcccttgtt
      301 tgccagaacc gaccagctgt gcagattccg aaaacgcctc cagcggtggt gacacagaag
      361 aagcttccag agaggaccca gctgtgagca cagaagctgc tgaagagctg cttcgcctcc
      421 ttgagtctgg acgcttgcct cccgcagacg tgctcatcct ggaccacatg aaaaccctgc
      481 tgcttctgca ggacaccgag agactgacga gcgccctgaa gatgttcccc gagcactgca
      541 tgatgcctcc agaccatgcc agaataatct cggctttctt taattattgg atcacgcaga
      601 ttcttcctga aaaacgcagt gaataaatca ttgtcacctg agaagagctg tcatttaaca
      661 cggagttatt aggtgcgcat aggatgcgaa ctgagactcc acgattgcac ataaagagtt
      721 atttattatt tttattttcg gcgaatcaaa ccctggagac attgaagaca tttctaccct
      781 gttatttatt tccgtgtttg tatgtcatag gtaaggtatc ctctgagact ttaagtgaga
      841 aactggggta aaatgagagc atttacttgc ttaccgttac acgtacattg atttacttca
      901 taaaactaga ttgtcttttg atgcctgtaa cagaaataga tattttatta aataaactat
      961 atagtttgaa gtta
//
LOCUS       NM_001127680            1400 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 2,
            mRNA.
ACCESSION   NM_001127680 XM_001075018 XM_225035
VERSION     NM_001127680.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced NM_001127680.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.883663.1,
                                           SRR26360176.1259533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  82203615-82203692
            79-225              JAXUCZ010000016.1  82217914-82218060
            226-360             JAXUCZ010000016.1  82234137-82234271
            361-789             JAXUCZ010000016.1  82264721-82265149
            790-978             JAXUCZ010000016.1  82268074-82268262
            979-1400            JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1400
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..78
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1052
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 2 is encoded by transcript variant 2;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 2"
                     /protein_id="NP_001121152.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSSLRKQVFTEKVLKRLFPNVSSGQEKGTPQTPALDTPSKDSTP
                     EAVQQKPVRGLTAGDIKIQPERRLYTVSLPPPGYIPCLPEPTSCADSENASSGGDTED
                     PGLPDQPKRRRIRRHKSKKSIKSLGGVTVRQTELETQREKTHPPHPDAPAMSRNKKRK
                     WRAKLRLRRKREAGLAARASAASFTYEPESSEEAEVEGDVGGEEEEDPESSVADPAQE
                     DTELASSRADSLLSFLKSTQEIYFYDASREDPAVSTEAAEELLRLLESGRLPPADVLI
                     LDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHARIISAFFNYWITQILPEKRSE"
     misc_feature    <687..>998
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     misc_feature    <687..>998
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     exon            79..225
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            226..360
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            361..789
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            790..978
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1400
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcaggtg tttactgaga aagtgctgaa gagacttttc cctaacgtct
      121 caagtggtca agaaaagggc actccccaga ctccagcttt ggacacacca tccaaggact
      181 cgacccctga agcggtacag cagaagcccg ttcgtggtct gacagctggt gacattaaga
      241 tccaacctga gcgtcgcctc tacaccgtga gtctgcctcc tccagggtat atcccttgtt
      301 tgccagaacc gaccagctgt gcagattccg aaaacgcctc cagcggtggt gacacagaag
      361 acccgggtct tcctgaccag ccgaaacgac gaagaattag acgacacaag tcaaagaaga
      421 gtattaaaag cctcggtggt gttaccgtaa ggcaaacgga actagagaca cagcgagaga
      481 aaacgcaccc gccacatcca gatgcccccg ccatgagcag aaataagaaa aggaagtgga
      541 gggcaaagct gaggctgagg aggaagagag aagccggctt agccgccagg gcctctgcgg
      601 ccagcttcac ctacgagccc gagagcagcg aggaggcaga ggtggagggc gatgtgggag
      661 gagaggaaga agaggatccc gagagctcag ttgcagaccc cgcccaggaa gacactgagc
      721 tcgccagcag cagggcggac agcctcctga gttttctgaa gtcaacacaa gaaatctact
      781 tctacgatgc ttccagagag gacccagctg tgagcacaga agctgctgaa gagctgcttc
      841 gcctccttga gtctggacgc ttgcctcccg cagacgtgct catcctggac cacatgaaaa
      901 ccctgctgct tctgcaggac accgagagac tgacgagcgc cctgaagatg ttccccgagc
      961 actgcatgat gcctccagac catgccagaa taatctcggc tttctttaat tattggatca
     1021 cgcagattct tcctgaaaaa cgcagtgaat aaatcattgt cacctgagaa gagctgtcat
     1081 ttaacacgga gttattaggt gcgcatagga tgcgaactga gactccacga ttgcacataa
     1141 agagttattt attattttta ttttcggcga atcaaaccct ggagacattg aagacatttc
     1201 taccctgtta tttatttccg tgtttgtatg tcataggtaa ggtatcctct gagactttaa
     1261 gtgagaaact ggggtaaaat gagagcattt acttgcttac cgttacacgt acattgattt
     1321 acttcataaa actagattgt cttttgatgc ctgtaacaga aatagatatt ttattaaata
     1381 aactatatag tttgaagtta
//
LOCUS       NM_001436574             482 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 8,
            mRNA.
ACCESSION   NM_001436574
VERSION     NM_001436574.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3293924.1,
                                           SRR26360172.395533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  82203615-82203692
            79-225              JAXUCZ010000016.1  82217914-82218060
            226-482             JAXUCZ010000016.1  82220348-82220604
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..482
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..78
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..341
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 7 is encoded by transcript variant 8;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 7"
                     /protein_id="NP_001423503.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSSLRKQVFTEKVLKRLFPNVSSGQEKGTPQTPALDTPSKDSTP
                     EAVQQKPVRGLTVRPPRKEMPSSASKLRTTIKHSILFNRSRSSSEYAQGC"
     exon            79..225
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            226..482
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcaggtg tttactgaga aagtgctgaa gagacttttc cctaacgtct
      121 caagtggtca agaaaagggc actccccaga ctccagcttt ggacacacca tccaaggact
      181 cgacccctga agcggtacag cagaagcccg ttcgtggtct gacagtgaga cctccaagga
      241 aggagatgcc aagtagtgct tcaaagcttc ggaccacaat caaacacagc atccttttca
      301 acagaagcag aagctcatct gaatatgctc aaggatgctg acatcaacat ttaatcatct
      361 cctcactcat ccaggaagaa ggagagatca gttactactg tattttattg tgttcaacca
      421 aatcaccatg ttacaaaaat agcaagctgc cataataaaa aataaggctc ctctatccag
      481 ca
//
LOCUS       NM_001108402            2812 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), transcript variant
            2, mRNA.
ACCESSION   NM_001108402 XM_001076079 XM_341468
VERSION     NM_001108402.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced NM_001108402.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225763.1, SRR26360181.3174597.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000016.1  84706158-84706216   c
            60-210              JAXUCZ010000016.1  84699112-84699262   c
            211-256             JAXUCZ010000016.1  84698119-84698164   c
            257-345             JAXUCZ010000016.1  84697425-84697513   c
            346-454             JAXUCZ010000016.1  84696157-84696265   c
            455-505             JAXUCZ010000016.1  84693098-84693148   c
            506-610             JAXUCZ010000016.1  84692913-84693017   c
            611-731             JAXUCZ010000016.1  84692286-84692406   c
            732-852             JAXUCZ010000016.1  84691110-84691230   c
            853-2812            JAXUCZ010000016.1  84688239-84690198   c
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2812
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..59
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1003
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /EC_number="4.2.1.93"
                     /note="isoform 2 is encoded by transcript variant 2;
                     carbohydrate kinase domain containing; ATP-dependent
                     NAD(P)HX dehydratase; carbohydrate kinase
                     domain-containing protein; ATP-dependent
                     (S)-NAD(P)H-hydrate dehydratase"
                     /codon_start=1
                     /product="ATP-dependent (S)-NAD(P)H-hydrate dehydratase
                     isoform 2"
                     /protein_id="NP_001101872.1"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
                     /translation="MGIRCVAIRACGGVLQRALSLHTAHATKDMDNLFQLVRNIVPAL
                     TSKKHKGQDGRIGIVGGCQEYTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPE
                     LIVHPVLDSSDAVEEVEKWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVI
                     DADGLWLIAQRPALVHGYQKAVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQAL
                     GNITIVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKT
                     NGSSPLLVAAWGACTLTRECNHLAFQKYGRSTTTTDMIAEVGAAFSKLFTT"
     misc_feature    164..967
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="B.subtilis YXKO protein of unknown function and
                     related proteins. Based on the conservation of the ATP
                     binding site, the substrate binding site and the
                     Mg2+binding site and structural homology this group is a
                     member of the ribokinase-like superfamily; Region:
                     YXKO-related; cd01171"
                     /db_xref="CDD:238576"
     misc_feature    164..967
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="B.subtilis YXKO protein of unknown function and
                     related proteins. Based on the conservation of the ATP
                     binding site, the substrate binding site and the
                     Mg2+binding site and structural homology this group is a
                     member of the ribokinase-like superfamily; Region:
                     YXKO-related; cd01171"
                     /db_xref="CDD:238576"
     misc_feature    order(230..232,773..775,782..784)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:238576"
     misc_feature    order(230..232,773..775,782..784)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:238576"
     misc_feature    order(575..577,695..697,776..781,788..790,899..901)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238576"
     misc_feature    order(575..577,695..697,776..781,788..790,899..901)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238576"
     exon            60..210
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            211..256
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            257..345
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            346..454
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            455..505
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            506..610
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            611..731
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            732..852
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            853..2812
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccgc tggacggtca tgggcatccg gtgtgtggcg atccgcgcct gcggaggagt
       61 tttacaaaga gcactgtccc tccacacagc gcacgcaaca aaggacatgg acaacctttt
      121 tcagttggtg aggaacattg tgcctgctct gacgtcgaag aaacacaagg ggcaagatgg
      181 aaggataggc atagtcgggg gctgtcaaga gtacacagga gcaccgtatt ttgcaggaat
      241 ctcagctctg aaagtgggtg cagatttgac ccacgtattc tgtgccaggg aggccgcgcc
      301 agtgatcaag tcctacagcc cagagctgat cgtccacccc gtccttgaca gttctgacgc
      361 tgttgaggag gtggagaaat ggctccccag gctgcatgcc cttgtcgtgg gacctggcct
      421 aggtagggac gaccttcttc tcaacaacgt gaggggcatc ttggaatcaa ccaaggccag
      481 ggacatccct gtcgtcattg acgcggacgg cctgtggctg attgctcagc ggccagccct
      541 cgtccacggc taccagaagg ccgttctcac ccccaaccat gtggagttca gcagactctg
      601 ggacgctgtg ctcagtagtc ctatggacac cagtaatcac agtggatctg tgttgaagct
      661 cagccaggcc ctggggaaca tcaccatagt ccagaaagga gagcaggacc tgatctccaa
      721 cggccagcag gtgcttgtgt gcaaccagga aggcagcagt cgccggtgtg gtgggcaagg
      781 agatctcctg tcaggctccc tgggtgtcat ggcacactgg gccctccgtg ctggaccaga
      841 gaaaaccaac ggctccagcc cgctcctggt ggctgcctgg ggtgcgtgca cactcacaag
      901 ggagtgtaac catctggcct tccagaagta cgggcgttcc acaaccacta ccgacatgat
      961 cgctgaggtg ggagctgcct tcagcaagct cttcacgacc tgagccggca cagactgagt
     1021 cctccatcgc ctagccttgg gctcagcagc acttgatgga ttttagcctg aagtagctga
     1081 caggatttag gacgtggctg tccgactact gtagagttga gatgttaagg acactaatct
     1141 ggtctccgtg gttttctggg cttctcagaa aagtctgagg agaaaatgag agtaaaccct
     1201 cccagcagcc cacctggatt gggctggctc tgacacagac atttggagtc catggctgtt
     1261 cattcattga ttctggtgcc tttttgtcac tacagtaacc acgcacaggg ctccagtctc
     1321 tgggtggtgg gggagcgcag ggtttgtttc ctaaccaagg ctcacaggat ggcattcttg
     1381 ggccttacag ttttctattc agtgactgag tgttaacttc gagaggagtt cagaagagac
     1441 agtggccatg cagaggagat cttttagcgg ccagtgggaa gggcaggaaa ccagggtgcc
     1501 actggcattt gagcgtggca gggagtgcca agatgccacg tctgctacct gtgttcactg
     1561 ctgtgtactg ggccctgcgc tccctgccga gcctccctcc aggctccctg acagctgcat
     1621 gcctagtgag taggggtctg ctctctggct ccccttgtgt ctggtccttg gtcacaaggg
     1681 acagctaacc atgtccagga atgtctcctg aacagacatg aacttactga agggaatggt
     1741 acgacgcaat taactttcca ggctgttccg aacacacacc agtgggcagc acaggctcac
     1801 tttactgtgg ctaaacagcc acaattagca actttaatat aaagttttta atacaaagtt
     1861 caccacaaag aaagcagatg ccatgcgtgg aggcacgtgg actgcagctg cctcatcctc
     1921 aagtcccggg cttctggtgt tttgtcctcg gatccagcag ttcccatgtg gaggctgcat
     1981 ggcctctgtc ctgaaggaga aagctctgga tagcatcaca tcctcttgtt catggtcaga
     2041 gagcaaaggc agagagagga ggcggaggag aggggggtga cactgcctga cagggccagc
     2101 tcctcgacca cgagggttga gttttgcagc tcttgctgct acacatcttc ccctcagccc
     2161 tccacccctg ccttgagtgg gcctgtctca gacactggat gaccagccac tgtccgcccc
     2221 tttactgcct gcgacattgg cagcccctgt acctgcagtg tcactcacct taacattgat
     2281 gccgtgggtc atgaggtcct ggcggagtgc gtcacatgcc tccagcaagg gctgcctctc
     2341 ctggagctgc tgtttccggg cctccccggt ggccccaggc gtggccagtg catactggcg
     2401 gaccttaagc ctgaagcgca ctagttcatc taccacacag tgcagggcta ctgtgctgct
     2461 gtctcctgaa acacactgag ccatagactc ttagatgagt ctgccccgca aggcaggagc
     2521 cccggtatag cctgggagac catactcgac tacattctgg gctgagacct gaagtcctta
     2581 ctagttaatc ctgatgagcc ctttctggag aatatgaggg gaggttaggt tagtaagacc
     2641 agctcagcaa gacttcatgc ctgactggct cacttaagct gaccctgacc caccaccaga
     2701 cctcagcaac agttgtaggg tgtgacaagt gtcaacagaa tcctgtcatc tccagagaat
     2761 ctagcagcct gagccttaag tgtgaataaa gacaaacatt tctgccatag aa
//
LOCUS       NM_001436569            1256 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436569
VERSION     NM_001436569.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1256)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.18718.1,
                                           SRR26360194.1570232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  82203615-82203692
            79-213              JAXUCZ010000016.1  82234137-82234271
            214-642             JAXUCZ010000016.1  82264721-82265149
            643-834             JAXUCZ010000016.1  82268071-82268262
            835-1256            JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1256
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..78
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..908
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 3 is encoded by transcript variant 3;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 3"
                     /protein_id="NP_001423498.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSSLRKQAGDIKIQPERRLYTVSLPPPGYIPCLPEPTSCADSEN
                     ASSGGDTEDPGLPDQPKRRRIRRHKSKKSIKSLGGVTVRQTELETQREKTHPPHPDAP
                     AMSRNKKRKWRAKLRLRRKREAGLAARASAASFTYEPESSEEAEVEGDVGGEEEEDPE
                     SSVADPAQEDTELASSRADSLLSFLKSTQEIYFYDEASREDPAVSTEAAEELLRLLES
                     GRLPPADVLILDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHARIISAFFNYWITQI
                     LPEKRSE"
     misc_feature    <540..>854
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     misc_feature    <540..>854
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     exon            79..213
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            214..642
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            643..834
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1256
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcaggct ggtgacatta agatccaacc tgagcgtcgc ctctacaccg
      121 tgagtctgcc tcctccaggg tatatccctt gtttgccaga accgaccagc tgtgcagatt
      181 ccgaaaacgc ctccagcggt ggtgacacag aagacccggg tcttcctgac cagccgaaac
      241 gacgaagaat tagacgacac aagtcaaaga agagtattaa aagcctcggt ggtgttaccg
      301 taaggcaaac ggaactagag acacagcgag agaaaacgca cccgccacat ccagatgccc
      361 ccgccatgag cagaaataag aaaaggaagt ggagggcaaa gctgaggctg aggaggaaga
      421 gagaagccgg cttagccgcc agggcctctg cggccagctt cacctacgag cccgagagca
      481 gcgaggaggc agaggtggag ggcgatgtgg gaggagagga agaagaggat cccgagagct
      541 cagttgcaga ccccgcccag gaagacactg agctcgccag cagcagggcg gacagcctcc
      601 tgagttttct gaagtcaaca caagaaatct acttctacga tgaagcttcc agagaggacc
      661 cagctgtgag cacagaagct gctgaagagc tgcttcgcct ccttgagtct ggacgcttgc
      721 ctcccgcaga cgtgctcatc ctggaccaca tgaaaaccct gctgcttctg caggacaccg
      781 agagactgac gagcgccctg aagatgttcc ccgagcactg catgatgcct ccagaccatg
      841 ccagaataat ctcggctttc tttaattatt ggatcacgca gattcttcct gaaaaacgca
      901 gtgaataaat cattgtcacc tgagaagagc tgtcatttaa cacggagtta ttaggtgcgc
      961 ataggatgcg aactgagact ccacgattgc acataaagag ttatttatta tttttatttt
     1021 cggcgaatca aaccctggag acattgaaga catttctacc ctgttattta tttccgtgtt
     1081 tgtatgtcat aggtaaggta tcctctgaga ctttaagtga gaaactgggg taaaatgaga
     1141 gcatttactt gcttaccgtt acacgtacat tgatttactt cataaaacta gattgtcttt
     1201 tgatgcctgt aacagaaata gatattttat taaataaact atatagtttg aagtta
//
LOCUS       NM_001436580            2665 bp    mRNA    linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 6, mRNA.
ACCESSION   NM_001436580 XM_063275573
VERSION     NM_001436580.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_063275573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099767.1, SRR22582419.1898746.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000016.1  82902867-82902983   c
            118-192             JAXUCZ010000016.1  82902097-82902171   c
            193-259             JAXUCZ010000016.1  82885930-82885996   c
            260-366             JAXUCZ010000016.1  82877461-82877567   c
            367-488             JAXUCZ010000016.1  82872461-82872582   c
            489-594             JAXUCZ010000016.1  82871768-82871873   c
            595-904             JAXUCZ010000016.1  82871245-82871554   c
            905-973             JAXUCZ010000016.1  82870780-82870848   c
            974-1125            JAXUCZ010000016.1  82869556-82869707   c
            1126-1292           JAXUCZ010000016.1  82869032-82869198   c
            1293-1371           JAXUCZ010000016.1  82868362-82868440   c
            1372-2665           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2665
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..117
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..192
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..259
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..366
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..488
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..594
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    584..586
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     exon            595..904
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..1519
                     /gene="Tfdp1"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 2"
                     /protein_id="NP_001423509.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKN
                     IRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQ
                     LQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDK
                     FEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYVTEMA
                     QGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGED
                     DDDDDDFNENDEED"
     misc_feature    647..865
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    647..865
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(878..880,890..892,899..904,908..913,920..925,
                     929..934,941..946,953..955,962..967,974..976,983..988,
                     992..997,1001..1009,1016..1018,1049..1084,1088..1090,
                     1121..1147,1151..1153,1157..1159,1163..1165,1181..1186,
                     1190..1192)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(878..880,890..892,899..904,908..913,920..925,
                     929..934,941..946,953..955,962..967,974..976,983..988,
                     992..997,1001..1009,1016..1018,1049..1084,1088..1090,
                     1121..1147,1151..1153,1157..1159,1163..1165,1181..1186,
                     1190..1192)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    878..1018
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    878..1018
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    884..1300
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    884..1300
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(950..952,959..964,971..973,1070..1072,1097..1099,
                     1103..1105,1148..1171,1190..1192)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(950..952,959..964,971..973,1070..1072,1097..1099,
                     1103..1105,1148..1171,1190..1192)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            905..973
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1125
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1292
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1371
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2665
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtgagcc cgcgtcccgg cgccgctggc tcagggcagg gaccgccagg gccggacctc
       61 cgggccggcg cccccgcgcc cccgtcgtcc gccccgcgcg ccccgccggc cagccagata
      121 agtccggttt cttctgtgga gggtacgcag ttaaagcctt gatttcctgg atctggtaac
      181 atggcaaaag atgccagtct aattgaagcc aacggagaac taaaggtctt tatagaccag
      241 aatcttagtc ctgggaaagg tgtggtgtct cttgtggctg tgcacccatc cacagtgaac
      301 acactgggga agcagctttt gccaaaaacc ttcggacagt ccaatgtcaa tatcacacag
      361 caagtggtga ttggcacgcc tcagagacct gcagcagcca acactattgt ggtaggaagc
      421 ccacacactc ccaacactca ctttgtgtcc cagaaccaga cgtctgactc ctcaccttgg
      481 tctgctggca gacgccttta gaacagtggt gcctagtgtg tggtccggat cagacccatg
      541 ctgatttctg cccttcggat gtctgtccgt cttcccagac atttaaaggc acaggaagcg
      601 gaacaggaaa ggtgagaaga atggcaaagg cctgcggcat ttctccatga aggtgtgtga
      661 gaaggtgcag aggaaaggga cgacctccta caatgaggtg gccgacgagc tggttgccga
      721 gttcagcgcc gctgacaacc acatcttacc caacgagtcc gcctacgacc agaagaacat
      781 ccggcggcgt gtgtacgatg ccttaaatgt gctgatggcc atgaacatca tctccaagga
      841 gaagaaggag atcaagtgga tcggcctgcc caccaactct gctcaggagt gccagaactt
      901 agaggtagag aggcagcgga ggctggagag gatcaaacaa aagcagtcac agctccagga
      961 gctcatcctg cagcaaattg ccttcaagaa cttggtgcag agaaatcgcc aagcggagca
     1021 gcaggcccgc aggccaccgc ctcccaactc tgtcatccac ttgcccttca tcattgtcaa
     1081 caccagcagg aagacagtca tcgactgcag catctccaat gacaaatttg agtatctgtt
     1141 caactttgac aacacgtttg aaatccacga tgatatcgag gtgctcaagc gcatgggcat
     1201 ggcctgtggg ctggagtcgg gcagctgctc tgctgaagac ctcaaggtgg cgagaagtct
     1261 ggtaccaaaa gctctagaac cgtatgtgac agagatggct cagggatcca ttggcggagt
     1321 atttgtcacg acaacaggtt ctacatccaa tggcacaagg ctttctgcca gtgatttgag
     1381 caatggtgca gatgggatgc tggccacgag ctccaatggg tctcagtaca gcggctccag
     1441 ggtggagacc cctgtgtcct acgttgggga ggatgacgac gacgacgatg actttaatga
     1501 gaacgacgag gaggattgat tactcaactg tagacccttc tcccctcagt cagcttcagg
     1561 aaaaacgtat agagaaaaga agcttttgaa gtggggcttt ccgttctttc tggcctactc
     1621 ccaagaagat gccgccgagt tgtggagtta gatatgcagc tccaagtaag gagtgtgccc
     1681 gcggtgtgag cgagctgtgg atgtgtcgtg aagccagcgt gctagagcag agcctgtatc
     1741 taccttttag gattttatgg ttcctctttc tttctttttt ttgtttatct tctttccttt
     1801 cttttttaag tttgaagctt gttttgcccc tcaacagttg ttgctggttt gctgaggagg
     1861 ctgtgctgcg cccccaccgg tgacagtggt aaagcgctgc ccgcctcggg tgtgcggcgc
     1921 ccaggtggtg gacagccagg cgttaggatg gattttccca tttgtcaaat catgcagagt
     1981 ccagagaaca aggcgatagc aaagctccac tgttaacgct gcgcgccata cgtctcatga
     2041 ctgtttttcc ttaaattata ctgactgtcc agttccatca atcaaccttt tctcaagcag
     2101 cagcaaagcg agaagtagtg tttcttgttt gtttgttttg ttttgtttgg aagaagttta
     2161 ctgccacgct ggcgcagcta tggaaattgt ctagaaagtt tgcttatggt aaatttgcct
     2221 gatttcttac aggctacgtt tggaaacttt ttattatata gtttacatac ttataagtct
     2281 atcatttaaa gacgtgtact gaaacaaatg ttgtatttgt ttcataagca tcttcctgta
     2341 atctattata aaattgaaat taaacataga gaatgtttta acagtttttt aactcaaaat
     2401 ttgtcaatca tttttaatag ttcttttttt ataaaaagaa aaaggaattt aaggacaggc
     2461 aatagtctct taaaatttat tcacaagaac cgttaactgc acagctgccc ttagctgcct
     2521 gttctaaatg atggtctttt tattgaaaca caaataaact tttctgtaat attttatgga
     2581 atataaagag actttaattg tttgacctgt ttaactaagc actgttagtt tttattaata
     2641 aaacgcgcat gggcatttta aacaa
//
LOCUS       NR_199175               6486 bp    RNA     linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus multifunctional ROCO family signaling regulator 1
            (Mfhas1), transcript variant 3, non-coding RNA.
ACCESSION   NR_199175 NM_001107316 XM_001058880 XM_224916 XR_001841536
VERSION     NR_199175.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6486)
  AUTHORS   Wang,H.H., Sun,P.F., Chen,W.K., Zhong,J., Shi,Q.Q., Weng,M.L.,
            Ma,D. and Miao,C.H.
  TITLE     High Glucose Stimulates Expression of MFHAS1 to Mitigate
            Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein
            Endothelial Cells
  JOURNAL   Inflammation 41 (2), 400-408 (2018)
   PUBMED   29168081
REFERENCE   2  (bases 1 to 6486)
  AUTHORS   Shi,Q., Xiong,B., Zhong,J., Wang,H., Ma,D. and Miao,C.
  TITLE     MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C
            subunit cytoplasm translocation and inhibition of c-Jun
            dephosphorylation at Thr239
  JOURNAL   Mol Immunol 88, 79-88 (2017)
   PUBMED   28609714
REFERENCE   3  (bases 1 to 6486)
  AUTHORS   Zhong,J., Wang,H., Chen,W., Sun,Z., Chen,J., Xu,Y., Weng,M.,
            Shi,Q., Ma,D. and Miao,C.
  TITLE     Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1
            macrophage polarization by activating JNK and p38 pathways
  JOURNAL   Cell Death Dis 8 (5), e2763 (2017)
   PUBMED   28471450
  REMARK    Erratum:[Cell Death Dis. 2018 Jul 16;9(8):782. doi:
            10.1038/s41419-018-0828-y. PMID: 30013073]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6486)
  AUTHORS   Zhong,J., Shi,Q.Q., Zhu,M.M., Shen,J., Wang,H.H., Ma,D. and
            Miao,C.H.
  TITLE     MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB
            Signaling Pathway Following Negative Regulation
  JOURNAL   PLoS One 10 (11), e0143662 (2015)
   PUBMED   26599367
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6486)
  AUTHORS   Dihanich,S., Civiero,L., Manzoni,C., Mamais,A., Bandopadhyay,R.,
            Greggio,E. and Lewis,P.A.
  TITLE     GTP binding controls complex formation by the human ROCO protein
            MASL1
  JOURNAL   FEBS J 281 (1), 261-274 (2014)
   PUBMED   24286120
REFERENCE   6  (bases 1 to 6486)
  AUTHORS   Kumkhaek,C., Aerbajinai,W., Liu,W., Zhu,J., Uchida,N.,
            Kurlander,R., Hsieh,M.M., Tisdale,J.F. and Rodgers,G.P.
  TITLE     MASL1 induces erythroid differentiation in human
            erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK
            pathway
  JOURNAL   Blood 121 (16), 3216-3227 (2013)
   PUBMED   23327923
REFERENCE   7  (bases 1 to 6486)
  AUTHORS   Ng,A.C., Eisenberg,J.M., Heath,R.J., Huett,A., Robinson,C.M.,
            Nau,G.J. and Xavier,R.J.
  TITLE     Human leucine-rich repeat proteins: a genome-wide bioinformatic
            categorization and functional analysis in innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 108 Suppl 1 (Suppl 1), 4631-4638 (2011)
   PUBMED   20616063
REFERENCE   8  (bases 1 to 6486)
  AUTHORS   Sakabe,T., Shinomiya,T., Mori,T., Ariyama,Y., Fukuda,Y.,
            Fujiwara,T., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, MASL1, within an amplicon at 8p23.1
            detected in malignant fibrous histiocytomas by comparative genomic
            hybridization
  JOURNAL   Cancer Res 59 (3), 511-515 (1999)
   PUBMED   9973190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 17, 2025 this sequence version replaced
            NM_001107316.1, XR_001841536.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.47138.1,
                                           SRR26360172.967848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3588              JAXUCZ010000016.1  63333418-63337005   c
            3589-3715           JAXUCZ010000016.1  63263863-63263989   c
            3716-3825           JAXUCZ010000016.1  63256531-63256640   c
            3826-6486           JAXUCZ010000016.1  63248829-63251489   c
FEATURES             Location/Qualifiers
     source          1..6486
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..6486
                     /gene="Mfhas1"
                     /note="multifunctional ROCO family signaling regulator 1"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
     misc_RNA        1..6486
                     /gene="Mfhas1"
                     /product="multifunctional ROCO family signaling regulator
                     1, transcript variant 3"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
     exon            1..3588
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    603..3743
                     /gene="Mfhas1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001107316.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            3589..3715
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3825
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..6486
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcttccc gatcgcgctc tcccagcgcc ggggacgcgg cgctcgcgct cccgcccgag
       61 ccgcggggaa acggagacaa ggagacgccg ccacctccgg cgccccggcc ctgctcccgc
      121 agcatgcccg ccgcggagcc gagcgccgcc ctcctcctgc agctagcgga ggcgacgccg
      181 ccggcctccg ggccgccgct gcgagggtag cggggccgga gtcggctact gaggcaaggc
      241 aaggcgggcg gagctggagg aggagcaggc atcctccgcg gcgcggcggg cggcggccct
      301 gctgcccggc gcgcccatgg cccgggagca cggagaatgc gagccgcgtt gcgcggccgc
      361 agccgagctc cgagccgctt gcccggagtc ccccaaagct gcctgcgtcg ctgccgctcc
      421 ccagctgcgg gctcccggcc actggctgtg ctaggaccca cagtcgccgg ccgcgcaggg
      481 gtggtggccc gggagcagcg ggagctagag ggcccgggag ctgggcgccg gccggagtcc
      541 agcgcggcat gcagctgcgg gctccggtac cggcgtgagg gttgtcggcg cgggctccgg
      601 ccatggctgg caaggacagt ggcaacctga agacggtgag gctgtggcgg gacgccgccc
      661 tgcgcgccag gaagctgcgg agcaacctgc gccagctcac gctcagctgc ccgggggcgg
      721 gaggcgactc actcgagtcc cccgacgccc cccagctggt gctgccggcc aacatcgggg
      781 acattgaggt gctgaacctg gggaacaacg gcctcgagga tgtgcctgaa ggtctggggt
      841 cagctctggg cagccttcgc gtcttggtct tgcgcaggaa ccgctttgcc cggctgcccc
      901 ctgcggtggc ggagctaggc caccacctta ccgaactgga cgtaagccac aaccggctaa
      961 ccatcctggg agccgaggtg gtgagcgccc taagggagct gcgcaaactc aacctgagcc
     1021 acaaccagct gccagccctg cctgcccagc tcggtgccct cgcccacctg gaggagctag
     1081 atgtcagctt caaccggcta gcgcatctgc cagattcctt ctcctgcctc aaccacctac
     1141 gtacccttga cgtggaccac aaccaactca ccgcctttcc ccagcagctg ctgcagctgg
     1201 ctgccctgga ggagctggac gtatccagca accggctgcg aggcctacct gaggatatca
     1261 gtgccctgcg tgccctcaag attctctggc ttagcggggc cgagcttggc actctgccca
     1321 gcggcttctg tgagctggcc agtttggaga gcctcatgtt agacaacaac gggctacagg
     1381 ctctgcccga cgagttcagc cgtctgcaaa ggctcaaaat gctcaacctt tcttccaacc
     1441 tcttcgagga gttccccgct gcgctgctgc ccctggctgg gctggaggag ctctacctta
     1501 gtcgcaatca gctcacctca gtgccctctc ttatcgccgg gctgggccgc cttctcacct
     1561 tgtggctgga taataaccgc atccgctacc tgccagactc cattgtggag ctgactggcc
     1621 tggaggagct ggtgcttcaa ggcaaccaga tcgctgttct gcctgacaac tttggccagc
     1681 tctcccgggt aggtttgtgg aaaatcaagg acaacccgct gattcagccc ccttacgaag
     1741 tctgcatgaa ggggatccct tatatcgcag cctaccagaa ggaactggct cattctcaac
     1801 cagcggttca gccccgtctc aagctgctcc tgatgggcca caaggctgcc ggaaagaccc
     1861 tgcttcgaca ctgcctcact gaggacaaag tggaaggagg gcaaggagga ggggacaagg
     1921 agaagagcta cctacctttc cctccccttg ggagtaaggg catcgaggtg accagctgga
     1981 ctgcggacgc ttcccggggc ttgcggttca ttgtgtatga cttagctggt gatgaaagct
     2041 acgaggtgat ccagcccttc ttcctctccc caggagccct atatgtgctc gtggtcaact
     2101 tggccaccta tgaacctcgt tgctttccta ctactgtggg ctccttcctg catcgggtgg
     2161 gggcccgtgt gcctcatgct gtggtgtgta ttgtgggcac acatgctgac ctgtgtgggg
     2221 agcgggagct tgaggagaag tgtctggata ttcaccgaca gattgccctg caggagaagc
     2281 atgatgcaga gggcctaagc catctagcca aggtggttga tgaggccctg gctcgggact
     2341 tcgagctacg ctctgccagt ccccatgcag cttactacgg tgtttcagac aagaaccttc
     2401 ggagacgcaa ggcccatttt cagtacctgc ttaaccaccg gctgcagatc ctctcgcccg
     2461 tgttgcctgt gagctgcagg gaccccctcc aactgcaacg ccttcgagac aagctgctct
     2521 ctgtagccga gcaccgggaa atctttccca acttacacag agtcctgcct cggtcctggc
     2581 aggtactgga ggagctgcac ttccagccac cccaggcaca acgtctgtgg ctaagctggt
     2641 gggactctgc ccgcttgggc ctgcaggcag gtctgactga ggaccggctc cagagtgccc
     2701 tttcttacct gcatgagagc ggcaaactgc tctattttga ggatagcccg gccctcaagg
     2761 agcacgtctt ccacaacctc acccgcctca ttgacatcct caatgttttt ttccagagag
     2821 atgcttcttt gctgcttcat aaactgctcc tagggaccaa cggagagggc gagggggagg
     2881 gggaaagttt ccccaccata gcagtgccca ctccgggcca ggacccactc cgggccaccc
     2941 agctccatca ttacgtggaa ggctttttgt tgcacgggct tctgccagct catatcattc
     3001 ggttgctgct caagcctcac gtccaggccc agcaggactt gcagctcctg ctggagctgc
     3061 tggagaagat gggactctgt tactgcctca ataaacccaa aggcaagcct ttgaacggct
     3121 ccgcagcttg gtacaagttc ccatgctacg tgcagaatga ggtgccccac gcggaggcct
     3181 ggattaatgg caccaaccta gccgggcagt cttttgtggc tgaacagttg cagatcgaat
     3241 acagttttcc ctttaccttc ccacctggat tgtttgcacg ttacagtgtt cagatcaaca
     3301 gccacgtggt gcacaggtcg gatgggaaat ttcagatctt tgcgtatcga gggaaagtgc
     3361 ccgtggtggt gagctacaga cctgccaagg gggtcctgca gccagacacc ctatccatcg
     3421 ccagccatgc gtcgctaccc aatatatgga ccgcatggca agccatcacc cctttggtag
     3481 aggaactgaa tgtcctactt caggaatggc ctggactaca ctacactgtg cacatcctct
     3541 gttctaagtg ccttaagaga gggtcgccaa atccacacgc tttcccaggg gagttgctga
     3601 gtcagcccag gccagaaggg gtggcagaga tcatctgccc caagaacggc agcgagcgcg
     3661 tgaatgtggc tttggtttac ccacctacac cgactgtgat cagcccttgt tccaagtacc
     3721 ttcgtacttt cttggaaaat taagtggaaa ggatagtgct tcttcccctc tgccaccatt
     3781 tttactgtac ccaatctgtg actttaggag caccaagttt taagggaaga acgttggtga
     3841 gaagcacaga aaccagtgac attcgtggct gtggaatttt catggcatta acagagcatg
     3901 ggaccgactg ggacatcttc tgcccctcac gagcctgcca tgctcccaag cgccttctgg
     3961 ggccccagag tgaaaccgtg caccgcatcg gggtgcttgc agaggaccct tggaggggtt
     4021 ggagggggct gggaagatgg ggacaaacat ggagcaaatg tttcacaacc tgaacctcag
     4081 aactgtgatc ctccaaggag agagctactt gaagaaaagg gaaaaaaaaa gttaacaggc
     4141 ttctcaggga ttgtgacttc tgtgtacaca tgagccataa agctccaggt caggcggcag
     4201 tatttagagc actcagattt cagttctgtt caatgtgaag gagggatcaa ctgacgttca
     4261 ccgctgtccc gtaactagtg taagatatgt atatgttaat ctttattttt ataatatgca
     4321 aatacattta aatttataca gttttggcgc ttctagcatt agttaacact gggtgcaata
     4381 ttctgcatga gaactgtgcc aagacggggc tgatgcttct agtgtcagac ctttggttct
     4441 tttcgttgcc ctttagccca cctgcttgac tgaaaaggac agagaaagct tctccctgtc
     4501 agtccgtcca ggggtaggtg caagaattct aataaccgcc aggagcgttc agcccattgg
     4561 cagagtcccc tcccatcttt tcagtgcaca ccctgcttgc tagtcactgg acatggtggt
     4621 agaatgatga ctattctgtc ccttcacatc accactactg gggcagaggg acatcctaga
     4681 ggccaaatga ggtgaagaat ctctgagaac ctgattcttg gagcaacttg cgataatctg
     4741 agttcagttc taaatcttgt agccgttcta ctgctatgca cccccctctc cctgaccccc
     4801 cagcacagtg tgcatgagtt agcagggccc tctgtgaact ctccatctga ctattggcct
     4861 tcctggagga acatccgttt cacggaactc catccctcat tggctgttta ttcatacaga
     4921 gccacttgga ggaagtctgc agccaaggtc ctagtagagc ccttgttttg aaacctctag
     4981 gaggtaaaca tttaaaaaca aactccacac actgctctcc agtggcctcc tagttaggac
     5041 caaacagcct ttgctgcagt agagacgcag tctctgaaga acgtgaaggc ctctgtttac
     5101 atctgcctct tccgtgtgtt gacaggaagc atgtaaaact gactgttccc cacaagaaag
     5161 gtgtgtcagc tggtcttact ctgtcgcctg cattctgaag tatcgattct tagaatgcca
     5221 cagcccacac cgtcaccaca aatctttaag agaaatgcaa gcaggtcact gcgctcttga
     5281 gaaattacag actgattcgt gttggatctg ttcagttgac ttcactgccc ccagaggccg
     5341 ctctgtggag gcaatctctc agaaatcaga atctagtggg gattgtctct cttttatgtt
     5401 tcgaatactt gaacacggca agtccagttt taaaaatttc tcttaccttt cagaacacag
     5461 ttgcaggatg ggtgagaatc tggttgatct cttctgtcat agttctcatg tgtgtgtgtg
     5521 tgcaagtgtg aaccgaacag tttgcatttc tattgcttcg tagaccactg aattattggg
     5581 caatagtttt ttgtttttgt tttttattaa ttggcaccag acagttctga aactgtcaag
     5641 tcagcaaagt ccaactagct ttacaatgtc ctatatgact ttgggcttac tccccagagg
     5701 gccatgtcaa ataaaaataa ggccccttgg gtgagcatac cctgcaaatg gttgctattt
     5761 tcataaacac agatgcccgt gttctgaatg cctgctactt tctgacaagt gatgttacat
     5821 gttgttatcc gaaccctaga gaagcaccga gaatgaggga accttggcgg tcacatgtgt
     5881 tgtggccaag gttggcacga tcagagggtc atgcacccga aagagctcca gcaaactgtg
     5941 agaacttgcc tcagtgtgtg ggggagaggg ctgagataca gaaacacctc tgcccaagaa
     6001 gaatctcagc atctgtgtag gaaattctgt ttccttattt cacacccggg aagactcagc
     6061 ggccagccgc tgaggggccg cccatccgct aagcacaaga ggaatgcgtt ctacccaagg
     6121 agcccctcgc ctctcacacg cgctccaagt ttgttatggt ttctattctt acaactcgtg
     6181 gtatcaaaac catttcctgg gattgttgaa gtgctgccag agtaaatggt ttcccccttc
     6241 tttggaaaaa caaaaacaaa caaaaacaaa aacaaaaaaa ccccgacagt gctcatattt
     6301 gatgtgtgca ctggactctt ttgaatgaat aaagtggaag ggcttgatag gattccagtg
     6361 gagtgtgtgt tttttcatgc tgcagtctgt gaattgtaac tgtggtttcc cggttcattg
     6421 tcctaacggg gcagaaattt aaaaaaaaaa aaaaatcaat aaaaacacaa tgaaatggtt
     6481 aagcca
//
LOCUS       NR_199178               2837 bp    RNA     linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), transcript variant
            5, non-coding RNA.
ACCESSION   NR_199178
VERSION     NR_199178.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2837)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 2837)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.42236.1,
                                           SRR22582419.1874264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000016.1  84706044-84706216   c
            174-324             JAXUCZ010000016.1  84699112-84699262   c
            325-370             JAXUCZ010000016.1  84698119-84698164   c
            371-479             JAXUCZ010000016.1  84696157-84696265   c
            480-530             JAXUCZ010000016.1  84693098-84693148   c
            531-635             JAXUCZ010000016.1  84692913-84693017   c
            636-756             JAXUCZ010000016.1  84692286-84692406   c
            757-877             JAXUCZ010000016.1  84691110-84691230   c
            878-2837            JAXUCZ010000016.1  84688239-84690198   c
FEATURES             Location/Qualifiers
     source          1..2837
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2837
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     misc_RNA        1..2837
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /product="NAD(P)HX dehydratase, transcript variant 5"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..173
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..373
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001108402.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            174..324
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            325..370
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            371..479
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            480..530
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            531..635
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            636..756
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            757..877
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            878..2837
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccgc tggacggtca tgggcatccg gtgtgtggcg atccgcgcct gcggaggagg
       61 taagatcgat accggcgtcc cgcggatggc tgtttgtccg tatggggctg cggcggtcgt
      121 gatggcactg ctctccgccg cgatcgcgtt ccactgttcg ccgctgctag cagttttaca
      181 aagagcactg tccctccaca cagcgcacgc aacaaaggac atggacaacc tttttcagtt
      241 ggtgaggaac attgtgcctg ctctgacgtc gaagaaacac aaggggcaag atggaaggat
      301 aggcatagtc gggggctgtc aagagtacac aggagcaccg tattttgcag gaatctcagc
      361 tctgaaagtg tgacagttct gacgctgttg aggaggtgga gaaatggctc cccaggctgc
      421 atgcccttgt cgtgggacct ggcctaggta gggacgacct tcttctcaac aacgtgaggg
      481 gcatcttgga atcaaccaag gccagggaca tccctgtcgt cattgacgcg gacggcctgt
      541 ggctgattgc tcagcggcca gccctcgtcc acggctacca gaaggccgtt ctcaccccca
      601 accatgtgga gttcagcaga ctctgggacg ctgtgctcag tagtcctatg gacaccagta
      661 atcacagtgg atctgtgttg aagctcagcc aggccctggg gaacatcacc atagtccaga
      721 aaggagagca ggacctgatc tccaacggcc agcaggtgct tgtgtgcaac caggaaggca
      781 gcagtcgccg gtgtggtggg caaggagatc tcctgtcagg ctccctgggt gtcatggcac
      841 actgggccct ccgtgctgga ccagagaaaa ccaacggctc cagcccgctc ctggtggctg
      901 cctggggtgc gtgcacactc acaagggagt gtaaccatct ggccttccag aagtacgggc
      961 gttccacaac cactaccgac atgatcgctg aggtgggagc tgccttcagc aagctcttca
     1021 cgacctgagc cggcacagac tgagtcctcc atcgcctagc cttgggctca gcagcacttg
     1081 atggatttta gcctgaagta gctgacagga tttaggacgt ggctgtccga ctactgtaga
     1141 gttgagatgt taaggacact aatctggtct ccgtggtttt ctgggcttct cagaaaagtc
     1201 tgaggagaaa atgagagtaa accctcccag cagcccacct ggattgggct ggctctgaca
     1261 cagacatttg gagtccatgg ctgttcattc attgattctg gtgccttttt gtcactacag
     1321 taaccacgca cagggctcca gtctctgggt ggtgggggag cgcagggttt gtttcctaac
     1381 caaggctcac aggatggcat tcttgggcct tacagttttc tattcagtga ctgagtgtta
     1441 acttcgagag gagttcagaa gagacagtgg ccatgcagag gagatctttt agcggccagt
     1501 gggaagggca ggaaaccagg gtgccactgg catttgagcg tggcagggag tgccaagatg
     1561 ccacgtctgc tacctgtgtt cactgctgtg tactgggccc tgcgctccct gccgagcctc
     1621 cctccaggct ccctgacagc tgcatgccta gtgagtaggg gtctgctctc tggctcccct
     1681 tgtgtctggt ccttggtcac aagggacagc taaccatgtc caggaatgtc tcctgaacag
     1741 acatgaactt actgaaggga atggtacgac gcaattaact ttccaggctg ttccgaacac
     1801 acaccagtgg gcagcacagg ctcactttac tgtggctaaa cagccacaat tagcaacttt
     1861 aatataaagt ttttaataca aagttcacca caaagaaagc agatgccatg cgtggaggca
     1921 cgtggactgc agctgcctca tcctcaagtc ccgggcttct ggtgttttgt cctcggatcc
     1981 agcagttccc atgtggaggc tgcatggcct ctgtcctgaa ggagaaagct ctggatagca
     2041 tcacatcctc ttgttcatgg tcagagagca aaggcagaga gaggaggcgg aggagagggg
     2101 ggtgacactg cctgacaggg ccagctcctc gaccacgagg gttgagtttt gcagctcttg
     2161 ctgctacaca tcttcccctc agccctccac ccctgccttg agtgggcctg tctcagacac
     2221 tggatgacca gccactgtcc gcccctttac tgcctgcgac attggcagcc cctgtacctg
     2281 cagtgtcact caccttaaca ttgatgccgt gggtcatgag gtcctggcgg agtgcgtcac
     2341 atgcctccag caagggctgc ctctcctgga gctgctgttt ccgggcctcc ccggtggccc
     2401 caggcgtggc cagtgcatac tggcggacct taagcctgaa gcgcactagt tcatctacca
     2461 cacagtgcag ggctactgtg ctgctgtctc ctgaaacaca ctgagccata gactcttaga
     2521 tgagtctgcc ccgcaaggca ggagccccgg tatagcctgg gagaccatac tcgactacat
     2581 tctgggctga gacctgaagt ccttactagt taatcctgat gagccctttc tggagaatat
     2641 gaggggaggt taggttagta agaccagctc agcaagactt catgcctgac tggctcactt
     2701 aagctgaccc tgacccacca ccagacctca gcaacagttg tagggtgtga caagtgtcaa
     2761 cagaatcctg tcatctccag agaatctagc agcctgagcc ttaagtgtga ataaagacaa
     2821 acatttctgc catagaa
//
LOCUS       NR_199176               2723 bp    RNA     linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), transcript variant
            3, non-coding RNA.
ACCESSION   NR_199176
VERSION     NR_199176.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101881.1, SRR26360190.2561424.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000016.1  84706158-84706216   c
            60-210              JAXUCZ010000016.1  84699112-84699262   c
            211-256             JAXUCZ010000016.1  84698119-84698164   c
            257-365             JAXUCZ010000016.1  84696157-84696265   c
            366-416             JAXUCZ010000016.1  84693098-84693148   c
            417-521             JAXUCZ010000016.1  84692913-84693017   c
            522-642             JAXUCZ010000016.1  84692286-84692406   c
            643-763             JAXUCZ010000016.1  84691110-84691230   c
            764-2723            JAXUCZ010000016.1  84688239-84690198   c
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2723
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     misc_RNA        1..2723
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /product="NAD(P)HX dehydratase, transcript variant 3"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..59
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..259
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001108402.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            60..210
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            211..256
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            257..365
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            366..416
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            417..521
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            522..642
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            643..763
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2723
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccgc tggacggtca tgggcatccg gtgtgtggcg atccgcgcct gcggaggagt
       61 tttacaaaga gcactgtccc tccacacagc gcacgcaaca aaggacatgg acaacctttt
      121 tcagttggtg aggaacattg tgcctgctct gacgtcgaag aaacacaagg ggcaagatgg
      181 aaggataggc atagtcgggg gctgtcaaga gtacacagga gcaccgtatt ttgcaggaat
      241 ctcagctctg aaagtgtgac agttctgacg ctgttgagga ggtggagaaa tggctcccca
      301 ggctgcatgc ccttgtcgtg ggacctggcc taggtaggga cgaccttctt ctcaacaacg
      361 tgaggggcat cttggaatca accaaggcca gggacatccc tgtcgtcatt gacgcggacg
      421 gcctgtggct gattgctcag cggccagccc tcgtccacgg ctaccagaag gccgttctca
      481 cccccaacca tgtggagttc agcagactct gggacgctgt gctcagtagt cctatggaca
      541 ccagtaatca cagtggatct gtgttgaagc tcagccaggc cctggggaac atcaccatag
      601 tccagaaagg agagcaggac ctgatctcca acggccagca ggtgcttgtg tgcaaccagg
      661 aaggcagcag tcgccggtgt ggtgggcaag gagatctcct gtcaggctcc ctgggtgtca
      721 tggcacactg ggccctccgt gctggaccag agaaaaccaa cggctccagc ccgctcctgg
      781 tggctgcctg gggtgcgtgc acactcacaa gggagtgtaa ccatctggcc ttccagaagt
      841 acgggcgttc cacaaccact accgacatga tcgctgaggt gggagctgcc ttcagcaagc
      901 tcttcacgac ctgagccggc acagactgag tcctccatcg cctagccttg ggctcagcag
      961 cacttgatgg attttagcct gaagtagctg acaggattta ggacgtggct gtccgactac
     1021 tgtagagttg agatgttaag gacactaatc tggtctccgt ggttttctgg gcttctcaga
     1081 aaagtctgag gagaaaatga gagtaaaccc tcccagcagc ccacctggat tgggctggct
     1141 ctgacacaga catttggagt ccatggctgt tcattcattg attctggtgc ctttttgtca
     1201 ctacagtaac cacgcacagg gctccagtct ctgggtggtg ggggagcgca gggtttgttt
     1261 cctaaccaag gctcacagga tggcattctt gggccttaca gttttctatt cagtgactga
     1321 gtgttaactt cgagaggagt tcagaagaga cagtggccat gcagaggaga tcttttagcg
     1381 gccagtggga agggcaggaa accagggtgc cactggcatt tgagcgtggc agggagtgcc
     1441 aagatgccac gtctgctacc tgtgttcact gctgtgtact gggccctgcg ctccctgccg
     1501 agcctccctc caggctccct gacagctgca tgcctagtga gtaggggtct gctctctggc
     1561 tccccttgtg tctggtcctt ggtcacaagg gacagctaac catgtccagg aatgtctcct
     1621 gaacagacat gaacttactg aagggaatgg tacgacgcaa ttaactttcc aggctgttcc
     1681 gaacacacac cagtgggcag cacaggctca ctttactgtg gctaaacagc cacaattagc
     1741 aactttaata taaagttttt aatacaaagt tcaccacaaa gaaagcagat gccatgcgtg
     1801 gaggcacgtg gactgcagct gcctcatcct caagtcccgg gcttctggtg ttttgtcctc
     1861 ggatccagca gttcccatgt ggaggctgca tggcctctgt cctgaaggag aaagctctgg
     1921 atagcatcac atcctcttgt tcatggtcag agagcaaagg cagagagagg aggcggagga
     1981 gaggggggtg acactgcctg acagggccag ctcctcgacc acgagggttg agttttgcag
     2041 ctcttgctgc tacacatctt cccctcagcc ctccacccct gccttgagtg ggcctgtctc
     2101 agacactgga tgaccagcca ctgtccgccc ctttactgcc tgcgacattg gcagcccctg
     2161 tacctgcagt gtcactcacc ttaacattga tgccgtgggt catgaggtcc tggcggagtg
     2221 cgtcacatgc ctccagcaag ggctgcctct cctggagctg ctgtttccgg gcctccccgg
     2281 tggccccagg cgtggccagt gcatactggc ggaccttaag cctgaagcgc actagttcat
     2341 ctaccacaca gtgcagggct actgtgctgc tgtctcctga aacacactga gccatagact
     2401 cttagatgag tctgccccgc aaggcaggag ccccggtata gcctgggaga ccatactcga
     2461 ctacattctg ggctgagacc tgaagtcctt actagttaat cctgatgagc cctttctgga
     2521 gaatatgagg ggaggttagg ttagtaagac cagctcagca agacttcatg cctgactggc
     2581 tcacttaagc tgaccctgac ccaccaccag acctcagcaa cagttgtagg gtgtgacaag
     2641 tgtcaacaga atcctgtcat ctccagagaa tctagcagcc tgagccttaa gtgtgaataa
     2701 agacaaacat ttctgccata gaa
//
LOCUS       NR_199177               2640 bp    RNA     linear   ROD 17-MAR-2025
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), transcript variant
            4, non-coding RNA.
ACCESSION   NR_199177
VERSION     NR_199177.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2640)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 2640)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.33169.1,
                                           SRR26643429.51301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000016.1  84706158-84706216   c
            60-127              JAXUCZ010000016.1  84699195-84699262   c
            128-173             JAXUCZ010000016.1  84698119-84698164   c
            174-282             JAXUCZ010000016.1  84696157-84696265   c
            283-333             JAXUCZ010000016.1  84693098-84693148   c
            334-438             JAXUCZ010000016.1  84692913-84693017   c
            439-559             JAXUCZ010000016.1  84692286-84692406   c
            560-680             JAXUCZ010000016.1  84691110-84691230   c
            681-2640            JAXUCZ010000016.1  84688239-84690198   c
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2640
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     misc_RNA        1..2640
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /product="NAD(P)HX dehydratase, transcript variant 4"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..59
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..250
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001108402.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            60..127
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            128..173
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            174..282
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            283..333
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            334..438
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            439..559
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            560..680
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            681..2640
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccgc tggacggtca tgggcatccg gtgtgtggcg atccgcgcct gcggaggagt
       61 tttacaaaga gcactgtccc tccacacagc gcacgcaaca aaggacatgg acaacctttt
      121 tcagttggta cacaggagca ccgtattttg caggaatctc agctctgaaa gtgtgacagt
      181 tctgacgctg ttgaggaggt ggagaaatgg ctccccaggc tgcatgccct tgtcgtggga
      241 cctggcctag gtagggacga ccttcttctc aacaacgtga ggggcatctt ggaatcaacc
      301 aaggccaggg acatccctgt cgtcattgac gcggacggcc tgtggctgat tgctcagcgg
      361 ccagccctcg tccacggcta ccagaaggcc gttctcaccc ccaaccatgt ggagttcagc
      421 agactctggg acgctgtgct cagtagtcct atggacacca gtaatcacag tggatctgtg
      481 ttgaagctca gccaggccct ggggaacatc accatagtcc agaaaggaga gcaggacctg
      541 atctccaacg gccagcaggt gcttgtgtgc aaccaggaag gcagcagtcg ccggtgtggt
      601 gggcaaggag atctcctgtc aggctccctg ggtgtcatgg cacactgggc cctccgtgct
      661 ggaccagaga aaaccaacgg ctccagcccg ctcctggtgg ctgcctgggg tgcgtgcaca
      721 ctcacaaggg agtgtaacca tctggccttc cagaagtacg ggcgttccac aaccactacc
      781 gacatgatcg ctgaggtggg agctgccttc agcaagctct tcacgacctg agccggcaca
      841 gactgagtcc tccatcgcct agccttgggc tcagcagcac ttgatggatt ttagcctgaa
      901 gtagctgaca ggatttagga cgtggctgtc cgactactgt agagttgaga tgttaaggac
      961 actaatctgg tctccgtggt tttctgggct tctcagaaaa gtctgaggag aaaatgagag
     1021 taaaccctcc cagcagccca cctggattgg gctggctctg acacagacat ttggagtcca
     1081 tggctgttca ttcattgatt ctggtgcctt tttgtcacta cagtaaccac gcacagggct
     1141 ccagtctctg ggtggtgggg gagcgcaggg tttgtttcct aaccaaggct cacaggatgg
     1201 cattcttggg ccttacagtt ttctattcag tgactgagtg ttaacttcga gaggagttca
     1261 gaagagacag tggccatgca gaggagatct tttagcggcc agtgggaagg gcaggaaacc
     1321 agggtgccac tggcatttga gcgtggcagg gagtgccaag atgccacgtc tgctacctgt
     1381 gttcactgct gtgtactggg ccctgcgctc cctgccgagc ctccctccag gctccctgac
     1441 agctgcatgc ctagtgagta ggggtctgct ctctggctcc ccttgtgtct ggtccttggt
     1501 cacaagggac agctaaccat gtccaggaat gtctcctgaa cagacatgaa cttactgaag
     1561 ggaatggtac gacgcaatta actttccagg ctgttccgaa cacacaccag tgggcagcac
     1621 aggctcactt tactgtggct aaacagccac aattagcaac tttaatataa agtttttaat
     1681 acaaagttca ccacaaagaa agcagatgcc atgcgtggag gcacgtggac tgcagctgcc
     1741 tcatcctcaa gtcccgggct tctggtgttt tgtcctcgga tccagcagtt cccatgtgga
     1801 ggctgcatgg cctctgtcct gaaggagaaa gctctggata gcatcacatc ctcttgttca
     1861 tggtcagaga gcaaaggcag agagaggagg cggaggagag gggggtgaca ctgcctgaca
     1921 gggccagctc ctcgaccacg agggttgagt tttgcagctc ttgctgctac acatcttccc
     1981 ctcagccctc cacccctgcc ttgagtgggc ctgtctcaga cactggatga ccagccactg
     2041 tccgcccctt tactgcctgc gacattggca gcccctgtac ctgcagtgtc actcacctta
     2101 acattgatgc cgtgggtcat gaggtcctgg cggagtgcgt cacatgcctc cagcaagggc
     2161 tgcctctcct ggagctgctg tttccgggcc tccccggtgg ccccaggcgt ggccagtgca
     2221 tactggcgga ccttaagcct gaagcgcact agttcatcta ccacacagtg cagggctact
     2281 gtgctgctgt ctcctgaaac acactgagcc atagactctt agatgagtct gccccgcaag
     2341 gcaggagccc cggtatagcc tgggagacca tactcgacta cattctgggc tgagacctga
     2401 agtccttact agttaatcct gatgagccct ttctggagaa tatgagggga ggttaggtta
     2461 gtaagaccag ctcagcaaga cttcatgcct gactggctca cttaagctga ccctgaccca
     2521 ccaccagacc tcagcaacag ttgtagggtg tgacaagtgt caacagaatc ctgtcatctc
     2581 cagagaatct agcagcctga gccttaagtg tgaataaaga caaacatttc tgccatagaa
//
LOCUS       NM_001436594            1086 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus clathrin, light chain A (Clta), transcript
            variant 4, mRNA.
ACCESSION   NM_001436594 XM_006238105
VERSION     NM_001436594.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Li,H., Alavian,K.N., Lazrove,E., Mehta,N., Jones,A., Zhang,P.,
            Licznerski,P., Graham,M., Uo,T., Guo,J., Rahner,C., Duman,R.S.,
            Morrison,R.S. and Jonas,E.A.
  TITLE     A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics
            during endocytosis
  JOURNAL   Nat Cell Biol 15 (7), 773-785 (2013)
   PUBMED   23792689
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Mettlen,M., Loerke,D., Yarar,D., Danuser,G. and Schmid,S.L.
  TITLE     Cargo- and adaptor-specific mechanisms regulate clathrin-mediated
            endocytosis
  JOURNAL   J Cell Biol 188 (6), 919-933 (2010)
   PUBMED   20231386
  REMARK    GeneRIF: The results underscore the highly dynamic and
            cargo-responsive nature of CCP assembly and suggest that the
            observed heterogeneity is, in part, related to compositional
            differences (e.g., cargo and adaptors) between CCPs.
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Drake,M.T., Downs,M.A. and Traub,L.M.
  TITLE     Epsin binds to clathrin by associating directly with the
            clathrin-terminal domain. Evidence for cooperative binding through
            two discrete sites
  JOURNAL   J Biol Chem 275 (9), 6479-6489 (2000)
   PUBMED   10692452
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Kirchhausen,T., Scarmato,P., Harrison,S.C., Monroe,J.J., Chow,E.P.,
            Mattaliano,R.J., Ramachandran,K.L., Smart,J.E., Ahn,A.H. and
            Brosius,J.
  TITLE     Clathrin light chains LCA and LCB are similar, polymorphic, and
            share repeated heptad motifs
  JOURNAL   Science 236 (4799), 320-324 (1987)
   PUBMED   3563513
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238105.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.708277.1,
                                           SRR22399489.2969745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000005.1  63041212-63041551
            341-378             JAXUCZ010000005.1  63047169-63047206
            379-496             JAXUCZ010000005.1  63048195-63048312
            497-608             JAXUCZ010000005.1  63052248-63052359
            609-644             JAXUCZ010000005.1  63057789-63057824
            645-1086            JAXUCZ010000005.1  63058782-63059223
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1086
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light chain A"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
     exon            1..340
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..816
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="isoform 4 is encoded by transcript variant 4;
                     clathrin, light polypeptide (Lca); clathrin, light chain
                     (Lca); lca"
                     /codon_start=1
                     /product="clathrin light chain A isoform 4"
                     /protein_id="NP_001423523.1"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKAS
                     NSTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRS
                     VLISLKQAPLVH"
     misc_feature    187..813
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     misc_feature    187..813
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     exon            341..378
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..608
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..644
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1086
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctcctc tccgctcgtc ctccggtagc agccgccagc acagtgtccg ctgctgggcg
       61 gggtgtcggc ggatcggtcg gttggtttcg gcttcggtgt cgctgcgttt gagttgggcc
      121 gtcatggctg agttggatcc atttggcgct cccgccggtg cgcccggtgg ccccgcgctc
      181 gggaacgggg tggcgggcgc cggcgaggaa gacccggccg cggccttctt ggcgcagcag
      241 gagagtgaga ttgcgggcat agagaacgac gaggccttcg ccatcctaga cggcggcgcc
      301 cccgggccgc aggcacacgg cgagccgccg gggggtcctg atgcggttga tggagtgatg
      361 aatggcgaat actaccagga gagcaatggt ccaacagaca gttacgcagc catttcagaa
      421 gtggatcggt tgcagtcaga gcctgaaagt atccgtaagt ggagagaaga gcagacagag
      481 cgcctggaag ccctcgatgc caattctcgg aagcaggaag cagagtggaa agaaaaggcc
      541 gtgaaggagc tggaagagtg gtacgcaagg caggacgagc agctacagaa gacaaaagcc
      601 agcaacagca caaacataaa ccatccttgc tacagcctag aacaggcagc agaagaagcc
      661 tttgtaaacg acattgacga gtcatcccca ggcactgagt gggagcgggt ggcccgcctg
      721 tgtgacttta accccaagtc cagcaaacag gccaaagatg tctctcgcat gcgctcagtc
      781 ctcatctccc tgaagcaggc gcccctggtg cattgaagag ccaccctgtg gaaacactac
      841 gtctccgatc ttaatcctac tcagtgaagc tgttcacgca attggattaa ttatgccgag
      901 ttcttttgga ccaaaccttt tgtctttaga gttgatcatt gtttgtgatt gcatgtttcc
      961 ttcaactgtg ttctccctgg cattcagaga agagagagga agaggaaggg aggggagctc
     1021 ccaacagtag cctcaacctg tgcttttgtg cattattctg agaataaatt tctgtttcaa
     1081 acaata
//
LOCUS       NM_001436601            2567 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 6, mRNA.
ACCESSION   NM_001436601
VERSION     NM_001436601.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28164.1,
                                           SRR26643291.15443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000005.1  126995787-126995912
            127-216             JAXUCZ010000005.1  127018017-127018106
            217-276             JAXUCZ010000005.1  127037215-127037274
            277-343             JAXUCZ010000005.1  127040034-127040100
            344-420             JAXUCZ010000005.1  127040190-127040266
            421-485             JAXUCZ010000005.1  127045623-127045687
            486-534             JAXUCZ010000005.1  127046262-127046310
            535-570             JAXUCZ010000005.1  127046896-127046931
            571-625             JAXUCZ010000005.1  127047469-127047523
            626-696             JAXUCZ010000005.1  127048676-127048746
            697-775             JAXUCZ010000005.1  127054592-127054670
            776-804             JAXUCZ010000005.1  127055509-127055537
            805-906             JAXUCZ010000005.1  127055633-127055734
            907-2567            JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2567
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..126
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    37..39
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MFGKLEPSPGTRGETHSLVAPIRLCATHIKSAAAAPSPVLGNIPPNDG"
     exon            127..216
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..936
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform d is encoded by transcript variant 6;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform d"
                     /protein_id="NP_001423530.1"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLL
                     PNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINM
                     GPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTM
                     INPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGIS
                     NPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    <214..864
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    <214..864
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     exon            217..276
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            277..343
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..420
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..485
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            486..534
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            535..570
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..625
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..696
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..775
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..804
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..906
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..2567
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgccctt ctgaagtaga ttcagagagg acggatatgt tcgggaagtt ggagccatca
       61 cctggcacca gaggggagac tcatagccta gtggctccta taaggctctg tgccacccac
      121 atcaagagtg cagcagctgc cccaagtcct gtgcttggca acattccccc caatgatggg
      181 atgcctggag gccccatccc accaggtttc tttcagcctt ttatgtcacc gagatatgca
      241 ggcggcccca ggcccccgat cagaatggga aaccagcctc caggaggagt tcctgggaca
      301 cagccattgc tgcccaattc catggatccc acacgacaac aaggtcaccc caacatggga
      361 gggtcaatgc agagaatgaa ccctccccga ggcatggggc ccatggggcc tggcccacag
      421 aattacggca gcggcatgag accaccaccc aactccctcg gccccgccat gcctgggatt
      481 aacatgggcc caggagctgg cagaccctgg cccaatccca acagtgctaa ctcaatcccg
      541 tactcctcct catcacccgg aacctatgtg ggaccccctg gtggtggcgg ccctcctgga
      601 acccccatca tgcctagtcc tgcggattca acaaattcca gtgacaacat ctacacaatg
      661 attaatcctg tgccgcctgg aggcagccgg tctaactttc caatgggtcc tggctcagat
      721 ggcccaatgg gcggcatggg aggcatggag ccacaccaca tgaatggatc cttaggatca
      781 ggcgacatag atggacttcc aaaaaattct cctaacaaca taagtggcat tagcaaccct
      841 ccaggcaccc ctcgggatga cggcgagctg ggggggaact tcctccactc cttccagaac
      901 gacaattatt ctccaagcat gacgatgagt gtgtgatccc ttctccacaa cgctgagagc
      961 cggcattgca ggcagaagat gccagaaatt atgcaagaag aagtgaggtg tcgataccag
     1021 gagctggggg agggcgtctc ctgctcccct ccatccctcc cattctctcc cccacctttc
     1081 ccaattttag tttcatgcaa taaaaaggcc aaacttttta ttccgtcaaa catgaaggac
     1141 aaaactcaga aatatatttc aagtcaacga ccagaaaaat ctcaccttct ccctgcccaa
     1201 aaggaccttt ctgtacatga cactttttgt tgggtttttt tgtttgtttg tttgtttgtt
     1261 tgtttgggat tttactgttg ctgggatttt aaatttgttt ttttgggggg attctttggg
     1321 ggaatttttt taatggaagc ttctagcaag ccctatgccc acccaatcaa cctcattgct
     1381 ttcttcttta ataaaaggaa aaaaggaaaa agaaaaaaaa ggccaaaaaa aaaaaaaaag
     1441 gaagaaaaac ccacaagccc tgctgtctat ccccaagtcc taccaccaga aaagctagtc
     1501 taggtgtgca atatcacact gatgttgtag ccatctaaaa ataataataa taaactggac
     1561 agtttacaat tggtggtttc tttcaaaagc tgtttgggga gaaggaactg aagtcaacgg
     1621 tttccacgtg ggcctttggg gtttgtgctg ggcaaggaga tgcaggtgtc cactttgctc
     1681 tggctgggct ggccatcaca acacactggg ccagaggacc cagagccccc aacttgccgt
     1741 cacccaacag agaccatcgc tgtgacccag cgtacacact gttccaggat ggctgcctct
     1801 tctccaaacc tctcatgccc agccacaggg gcctccagtc cctcggtccc caccgtttcc
     1861 tggcaagaat cctgctggct gggtagtggc ccaggctgtg taggagaggc cccaccaaca
     1921 ggatgactac aatctgggcc atagaactga cctccatgtt ctggtcccga gctcctcaca
     1981 tagtgcgcac tggcagggcg ggctgaagtt gtgtttttct ttttttctcc tgtttgtcct
     2041 ttttcaaaga tgggtgttgg ttggaattgc tctgtatttg cttggaactg gatggacaga
     2101 cttcagcatt gctgtggggt ggggggagca ccagcaacca aacagacact gtttctggtc
     2161 ctgtttttat tttcaaaaac tgatgaacct gatggtggag cctgtcccct ctgaggaggg
     2221 gtgacttggc tgccctggcc tctccccgtg gcaaccattg tgtcttgctc cggaagacac
     2281 tgagttcttt gtacatttac cccctctgtg ccccgcccat cctcgtagct ggtctttgtt
     2341 ttcttacctc ccctttctga cccatgtata tcatattatg tgagatacca tctgcctgac
     2401 aaaagacttg tgcggatcct tgggaacatt gtagctgttt ctgtgttttt tcttaccttg
     2461 tagtctggtt ctgaattatg agaggaaaaa aagtaattat gatacattgt agtttgtgta
     2521 cgatatatgt tgataacgtt ttattaaagg gacatctttt ttccgca
//
LOCUS       NM_001436615            2622 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 5, mRNA.
ACCESSION   NM_001436615
VERSION     NM_001436615.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2622)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2622)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2622)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2478537.1,
                                           SRR26643293.75530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000016.1  73925905-73926137
            234-313             JAXUCZ010000016.1  73926790-73926869
            314-369             JAXUCZ010000016.1  73927485-73927540
            370-448             JAXUCZ010000016.1  73929777-73929855
            449-525             JAXUCZ010000016.1  73930126-73930202
            526-703             JAXUCZ010000016.1  73931687-73931864
            704-769             JAXUCZ010000016.1  73932826-73932891
            770-841             JAXUCZ010000016.1  73934031-73934102
            842-999             JAXUCZ010000016.1  73934279-73934436
            1000-1081           JAXUCZ010000016.1  73935273-73935354
            1082-1218           JAXUCZ010000016.1  73939574-73939710
            1219-1408           JAXUCZ010000016.1  73941664-73941853
            1409-1504           JAXUCZ010000016.1  73946164-73946259
            1505-1700           JAXUCZ010000016.1  73947426-73947621
            1701-1791           JAXUCZ010000016.1  73957828-73957918
            1792-2008           JAXUCZ010000016.1  73958685-73958901
            2009-2095           JAXUCZ010000016.1  73973622-73973708
            2096-2210           JAXUCZ010000016.1  73974416-73974530
            2211-2373           JAXUCZ010000016.1  73981312-73981474
            2374-2427           JAXUCZ010000016.1  73983410-73983463
            2428-2622           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2622
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..233
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            234..313
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2440
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 4 is encoded by transcript variant 5; a
                     disintegrin and metalloprotease domain (ADAM) 5; tMDC II;
                     a disintegrin and metalloprotease domain 5; disintegrin
                     and metalloproteinase domain-containing protein 5;
                     transmembrane metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein II; a disintegrin and
                     metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 4"
                     /protein_id="NP_001423544.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MAYLITINENPHFIHLKKQSFITSTAVSYTYDRQDVRHSQSLSS
                     LKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQ
                     QAKIPDLGENQTYSWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDT
                     RVVLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHK
                     YRPQHISYLLAFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSI
                     GIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPM
                     ERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECC
                     GQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCM
                     TSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKR
                     LLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMF
                     CLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSID
                     DGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRER
                     SEGTSCITEDSVSNTKMTTNEGSTLH"
     misc_feature    <320..604
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    <320..604
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    731..1312
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    731..1312
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1373..1597
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1373..1597
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1607..2038
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1607..2038
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            314..369
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            370..448
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            449..525
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            526..703
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            704..769
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            770..841
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            842..999
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1081
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1218
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1408
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1504
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1700
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1791
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2008
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2095
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2210
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2373
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2427
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2622
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttccggc ttctggcttc tgagggacag aagcgaagtc tgcaacccca ggctcactgc
       61 actagttttg ctttcttttt gctcctcttt ggctgcaaaa cattcgctgg aaagggacgg
      121 gtttcttaac tataacatag ataacaatga atcgtatccc ggctaccaat tctgttacta
      181 tgtaaatggt agtcttgact caattcatca ccacaaagaa actggctttt ttgatcctca
      241 gaaaaccatc ctgcaaacaa ctgttcctga aaagatctca tcaccagatg tggaaacaga
      301 tccagaaaac catatggctt atcttattac aataaatgaa aacccccatt tcatccatct
      361 taaaaagcaa tcgtttataa cttcaactgc agtgagttat acatatgaca gacaagatgt
      421 tcggcattct cagtctttgt catctctgaa aaattgcaat tacaacggat acgttgcagg
      481 ttttccaaat tctatcgtgt cgctcaccgt ttgctcagga ctcaggggaa tgatacaatt
      541 tgaaaatgtc tcctatggaa tcgaacctgt ggaaaccctg tcaggattta tacacgtgat
      601 ctatgagaac acaaatcagc aagctaagat tcctgactta ggagagaatc agacgtacag
      661 ttggtctgat gaattagatt atcaattccg aagcaacatg aagaaatccg gatttgccgt
      721 gttacggcca cggtacatta agacggatat cgtcgtggat aaaaagctgt ttgattacat
      781 gggctccgac actagggtcg tgctacagaa agtcattcag atcatcggtt tcattaacac
      841 tatgttctcc aagttgaaac tgacggtttt aataaattcc gttgaaatct ggtcgaagga
      901 aaacagaatt gatttcccag aggcacctga aaacttactg gtccagtttt tacattggaa
      961 acataagtat agaccgcagc acatttcata cttactggca tttgtggagc atcctgcttc
     1021 cacgggagcc ctctatccgg ggaatctgtg caaaccgatc tatggtgctg ccattgccct
     1081 gtaccctaaa ggtttgtcac tagagtccta cagcgtcatc gtcctacaac tactgagcat
     1141 cggtataggc ttaacctatg acaacgctga cagctgccac tgtacaggag acgtctgcct
     1201 gatgacgccc aaggcaatat attctggggg tgtgaaggac ttcagtactt gtagcttgga
     1261 tgacttcaaa tacctgtcaa cacaagacct tgaatgtctc caggacttgc ctatggaaag
     1321 acaaaagaag aagccttcca ggccaaggag aatctgtggc aacgggatat tggaaatgaa
     1381 cgagcagtgt gactgtggca ctttgaagaa ttgtacacac aaaaaatgct gtgaccccat
     1441 gtcgtgccga ctgaagtcca aagccgtgtg tggctccggg gagtgctgtg gtcaggactg
     1501 caaggtaaaa ccggttaatg tactctgtag aaagtcgaag aatgaatgtg actttgagga
     1561 gtactgtaac ggaaatgacg cttactgtgt ccctgacacg ttcgcacgca acgggcagta
     1621 ctgcgactca gggcaagcct tctgctacag tggtctttgt atgacgagta ataatcaatg
     1681 catgaacttg ctcgggaaat atgtgagagg agcttccttc gcatgctatg aagagttcaa
     1741 ttccagaaac gatagatttg gcaactgtat tagaaagttt tgtagtttcg aaaattctct
     1801 ctgtgggaag ttggtctgta cctggccatt caagaggctg ctcatgaaag acaatatgtc
     1861 tgcggcttat ggacaaatcc gagacgattt atgcatctct ctgtataaag gagggaggcc
     1921 acttaagaca acattgtcaa catattccga tatgtcagaa agagacgaaa catttgtaaa
     1981 agacggcaca atctgtggtc ctgatatgtt ttgtttggaa acacagtgca aagaaacgag
     2041 atttttggtg gattttcaac agtgcaatac ttcccgagat tgcaatgacc atggggtttg
     2101 caacaacttt aatcattgtc attgtgataa aggatataac cctccctatt gtgagtcagt
     2161 aaaaggacag tttggaagca ttgatgacgg ccacaaatat tacattgacg aagggaaaag
     2221 cgctaagcag cagaatcgtg gtattcaccc aaagcagcaa ctccagctta ttctgtatat
     2281 aacgctgccc ttgattatga ttatctcggc tgtatttata aagcaaagca aactgagtcg
     2341 gctatgcggc agagaaagaa gcgaaggcac cagctgtata acagaagaca gtgtgagtaa
     2401 caccaagatg accaccaacg aaggaagcac ccttcactaa ccacctcaag tgttgccacc
     2461 caaaaagaag atagtctgga ttaaccacgg gaaactggca ttttgagcaa gaggaagggg
     2521 aaaaaaccac ccccaaacca acccacagct tctctcccac ttctgcagag ataaatgagg
     2581 actctaaacc atgaactaat aaatcagcgg tggctgaaca aa
//
LOCUS       NM_001436625            4575 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 6,
            mRNA.
ACCESSION   NM_001436625 XM_006237719
VERSION     NM_001436625.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4575)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 4575)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 4575)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 4575)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 4575)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 4575)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237719.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-4575           JAXUCZ010000005.1  6903906-6906241
FEATURES             Location/Qualifiers
     source          1..4575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4575
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423554.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..4575
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagt tttgactgtg attcagtatg gttacctatt gctgtaattg
     2281 ttttgactct tcagtgaagt cataacaact agtggagttg aacccacagt tctgccttgg
     2341 tgtcttcatc cctttaactg ccacacccca gtcagactca gacacaggca aggaggcttg
     2401 aattgggatg ggatcacaag agaaatgaaa cttggaaaat tcagccagag gacctttcag
     2461 gttcttcagg aatgctttgt gtctttgggg tcctctggga gctgaagcat acagccatgt
     2521 tggaaagcag agcttaataa tgattctttt ttaaaatctg ctgaagcagc cccatccggc
     2581 gaagttcttg gcgttggcta ctccatctgt cctagcagag tgtgactaaa ctggaaatgt
     2641 atggacctgc aatttttttt ttgatggaag tcaacagctg ccttactatt ttaccatctg
     2701 acgtttttag tagggagctg ggttgagaag actgccagag gaatgcagtc tgaggattgt
     2761 gttgcagtgg gcatggcgcc aacattcact cctatctcat tagaagaagt aggtagcagc
     2821 atcactcaga ggtcttctgc tgtgacctac tgctttaaca tctcctggaa tgttctgaaa
     2881 gggaatattt catttgcttg tgcacaactc tgctcatttt tgctgtttat ttaaatatga
     2941 ccgcatagtc atcttccact cgcaatcctg gctggatgag aagacacagg ttgcatctca
     3001 aggaaaagca acaacaaaag actagttaaa aaatatatag tgtttatttt aatagcaata
     3061 cattgttttc atgttgttta ttctttttaa atcaataaaa gatttattta tctttaaaat
     3121 atagtgatct gaaggtatta taccttccaa agaaataatt taatattaaa tatttttaac
     3181 accattgagg tgaattgttg acgcactcag gtgctacatt ttacaagctg aaagactaca
     3241 tattaccaag aagtgtagtc aaaatgttgc atggatttca gtaatcagtg gttaaaggtt
     3301 cggtttcatt gctgacgtat gttacaacca aataaaatct tgtcagtggc tctgttaatt
     3361 cccatgaaag ttaagcaaga tctattaata gctactcttc tctttctcta ccccaccccc
     3421 agctcgaatt ttggttgaat gcattcaggt agacagtaaa gttttgttaa gtcactgccc
     3481 cttctctgcc ttcagtgttt ttcaaagttg ttttgtaatt ctattttaaa ttttaaagac
     3541 ttagatggtt ttattttaaa tatttgtctt ttgctgtcct gtatcattct gatgttgatt
     3601 ttttttctat tatataattt actgagaagc atgcttaact agggaaacta catgatcttt
     3661 ataaaaaaat aattatttaa aaagaaatca gtgtaggaaa gatatgtctg aatctcttaa
     3721 aggcattgcc ttgtggaggg ggaagtcttc ctaactttta tccaggatat catggtgtca
     3781 gccgagtctc ttacttaggg gcctttgcag agacagtgtg tgtcactccc ctgatagcac
     3841 aggagaggac cacatgcttc atcacctaca gggtagtaaa ccagtggtgg tctctccaga
     3901 agtgcaatat attgagactc ttgggtatga ccaatatgga ttaaagaaga aggcagaaag
     3961 agagcaaatg aaaataaaat tacaacttgt atatttattt tttacatttt gctttgactt
     4021 tagggagtcc atttttactc aagaacaaac taagtctgtc tgtcgtctgc atagtctccc
     4081 tgcctgttcc tacccttgaa gctccttatg ctgggaaggc tgtttgtttg tttttttaag
     4141 aaatagaata tttaatctga ataagtgttt atttaaatgt gtaatgcttt gaaaataatg
     4201 ggcaacagag aactaaagga tgtttataaa gtgagcttgt tggctccatt tataaatata
     4261 tacgatttat aagctttttt aaaacaaagc tcaaattgtg ggtatttttc taaaatgtgc
     4321 acagctgtat tttccatgaa ggatctttct aatgggttgt tatactgtac tctacatttt
     4381 ggacagcaca tgaagtctgc caatgtactt aataaaacat gactttgttt atttaaagtt
     4441 tcttgctgtg aaaaacccta ccagtgggtt ccttaattta taatccttaa aaccaaaatg
     4501 tataatgtac agtttccaca actgtaactg ccctaataaa aatgttggtt attaataaag
     4561 ttcgagatgt ctttc
//
LOCUS       NM_001436626            4676 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 7,
            mRNA.
ACCESSION   NM_001436626
VERSION     NM_001436626.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4676)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 4676)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 4676)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 4676)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 4676)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 4676)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20315.1,
                                           SRR26643296.14499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-4676           JAXUCZ010000005.1  6903709-6906241
FEATURES             Location/Qualifiers
     source          1..4676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4676
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423555.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..4676
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagg taagcatagc cttaatttct ataaaacatc acagtaacat
     2281 cgttttctcc aattccaatt tacaactttt ttaaaacaat gacattgtcc ttcactttag
     2341 ttttgactgt gattcagtat ggttacctat tgctgtaatt gttttgactc ttcagtgaag
     2401 tcataacaac tagtggagtt gaacccacag ttctgccttg gtgtcttcat ccctttaact
     2461 gccacacccc agtcagactc agacacaggc aaggaggctt gaattgggat gggatcacaa
     2521 gagaaatgaa acttggaaaa ttcagccaga ggacctttca ggttcttcag gaatgctttg
     2581 tgtctttggg gtcctctggg agctgaagca tacagccatg ttggaaagca gagcttaata
     2641 atgattcttt tttaaaatct gctgaagcag ccccatccgg cgaagttctt ggcgttggct
     2701 actccatctg tcctagcaga gtgtgactaa actggaaatg tatggacctg caattttttt
     2761 tttgatggaa gtcaacagct gccttactat tttaccatct gacgttttta gtagggagct
     2821 gggttgagaa gactgccaga ggaatgcagt ctgaggattg tgttgcagtg ggcatggcgc
     2881 caacattcac tcctatctca ttagaagaag taggtagcag catcactcag aggtcttctg
     2941 ctgtgaccta ctgctttaac atctcctgga atgttctgaa agggaatatt tcatttgctt
     3001 gtgcacaact ctgctcattt ttgctgttta tttaaatatg accgcatagt catcttccac
     3061 tcgcaatcct ggctggatga gaagacacag gttgcatctc aaggaaaagc aacaacaaaa
     3121 gactagttaa aaaatatata gtgtttattt taatagcaat acattgtttt catgttgttt
     3181 attcttttta aatcaataaa agatttattt atctttaaaa tatagtgatc tgaaggtatt
     3241 ataccttcca aagaaataat ttaatattaa atatttttaa caccattgag gtgaattgtt
     3301 gacgcactca ggtgctacat tttacaagct gaaagactac atattaccaa gaagtgtagt
     3361 caaaatgttg catggatttc agtaatcagt ggttaaaggt tcggtttcat tgctgacgta
     3421 tgttacaacc aaataaaatc ttgtcagtgg ctctgttaat tcccatgaaa gttaagcaag
     3481 atctattaat agctactctt ctctttctct accccacccc cagctcgaat tttggttgaa
     3541 tgcattcagg tagacagtaa agttttgtta agtcactgcc ccttctctgc cttcagtgtt
     3601 tttcaaagtt gttttgtaat tctattttaa attttaaaga cttagatggt tttattttaa
     3661 atatttgtct tttgctgtcc tgtatcattc tgatgttgat tttttttcta ttatataatt
     3721 tactgagaag catgcttaac tagggaaact acatgatctt tataaaaaaa taattattta
     3781 aaaagaaatc agtgtaggaa agatatgtct gaatctctta aaggcattgc cttgtggagg
     3841 gggaagtctt cctaactttt atccaggata tcatggtgtc agccgagtct cttacttagg
     3901 ggcctttgca gagacagtgt gtgtcactcc cctgatagca caggagagga ccacatgctt
     3961 catcacctac agggtagtaa accagtggtg gtctctccag aagtgcaata tattgagact
     4021 cttgggtatg accaatatgg attaaagaag aaggcagaaa gagagcaaat gaaaataaaa
     4081 ttacaacttg tatatttatt ttttacattt tgctttgact ttagggagtc catttttact
     4141 caagaacaaa ctaagtctgt ctgtcgtctg catagtctcc ctgcctgttc ctacccttga
     4201 agctccttat gctgggaagg ctgtttgttt gtttttttaa gaaatagaat atttaatctg
     4261 aataagtgtt tatttaaatg tgtaatgctt tgaaaataat gggcaacaga gaactaaagg
     4321 atgtttataa agtgagcttg ttggctccat ttataaatat atacgattta taagcttttt
     4381 taaaacaaag ctcaaattgt gggtattttt ctaaaatgtg cacagctgta ttttccatga
     4441 aggatctttc taatgggttg ttatactgta ctctacattt tggacagcac atgaagtctg
     4501 ccaatgtact taataaaaca tgactttgtt tatttaaagt ttcttgctgt gaaaaaccct
     4561 accagtgggt tccttaattt ataatcctta aaaccaaaat gtataatgta cagtttccac
     4621 aactgtaact gccctaataa aaatgttggt tattaataaa gttcgagatg tctttc
//
LOCUS       NM_001436619            5720 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 2
            (Cdk5rap2), transcript variant 3, mRNA.
ACCESSION   NM_001436619 XM_039109347
VERSION     NM_001436619.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5720)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   2  (bases 1 to 5720)
  AUTHORS   Gao,F.J., Shi,L., Hines,T., Hebbar,S., Neufeld,K.L. and Smith,D.S.
  TITLE     Insulin signaling regulates a functional interaction between
            adenomatous polyposis coli and cytoplasmic dynein
  JOURNAL   Mol Biol Cell 28 (5), 587-599 (2017)
   PUBMED   28057765
REFERENCE   3  (bases 1 to 5720)
  AUTHORS   Park,J.S., Lee,M.K., Kang,S., Jin,Y., Fu,S., Rosales,J.L. and
            Lee,K.Y.
  TITLE     Species-Specific Expression of Full-Length and Alternatively
            Spliced Variant Forms of CDK5RAP2
  JOURNAL   PLoS One 10 (11), e0142577 (2015)
   PUBMED   26550838
  REMARK    GeneRIF: mouse expresses only one form of CDK5RAP2 that is
            equivalent to the human and rat alternatively spliced variant forms
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5720)
  AUTHORS   Mori,Y., Inoue,Y., Tanaka,S., Doda,S., Yamanaka,S., Fukuchi,H. and
            Terada,Y.
  TITLE     Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein,
            Binds to CDK5RAP2 and Regulates Microtubule Stability
  JOURNAL   PLoS One 10 (10), e0140968 (2015)
   PUBMED   26485573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5720)
  AUTHORS   Yigit,G., Brown,K.E., Kayserili,H., Pohl,E., Caliebe,A.,
            Zahnleiter,D., Rosser,E., Bogershausen,N., Uyguner,Z.O.,
            Altunoglu,U., Nurnberg,G., Nurnberg,P., Rauch,A., Li,Y., Thiel,C.T.
            and Wollnik,B.
  TITLE     Mutations in CDK5RAP2 cause Seckel syndrome
  JOURNAL   Mol Genet Genomic Med 3 (5), 467-480 (2015)
   PUBMED   26436113
REFERENCE   6  (bases 1 to 5720)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   7  (bases 1 to 5720)
  AUTHORS   Hassan,M.J., Khurshid,M., Azeem,Z., John,P., Ali,G., Chishti,M.S.
            and Ahmad,W.
  TITLE     Previously described sequence variant in CDK5RAP2 gene in a
            Pakistani family with autosomal recessive primary microcephaly
  JOURNAL   BMC Med Genet 8, 58 (2007)
   PUBMED   17764569
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5720)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 5720)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 5720)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039109347.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MF541099.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000005.1  88975683-88975909   c
            228-295             JAXUCZ010000005.1  88969093-88969160   c
            296-363             JAXUCZ010000005.1  88966558-88966625   c
            364-474             JAXUCZ010000005.1  88946102-88946212   c
            475-551             JAXUCZ010000005.1  88942797-88942873   c
            552-675             JAXUCZ010000005.1  88937564-88937687   c
            676-830             JAXUCZ010000005.1  88934516-88934670   c
            831-993             JAXUCZ010000005.1  88929034-88929196   c
            994-1035            JAXUCZ010000005.1  88927960-88928001   c
            1036-1155           JAXUCZ010000005.1  88927024-88927143   c
            1156-1374           JAXUCZ010000005.1  88919655-88919873   c
            1375-1545           JAXUCZ010000005.1  88901850-88902020   c
            1546-1686           JAXUCZ010000005.1  88897081-88897221   c
            1687-1784           JAXUCZ010000005.1  88888818-88888915   c
            1785-1909           JAXUCZ010000005.1  88883900-88884024   c
            1910-2019           JAXUCZ010000005.1  88882346-88882455   c
            2020-2148           JAXUCZ010000005.1  88880533-88880661   c
            2149-2333           JAXUCZ010000005.1  88871901-88872085   c
            2334-2766           JAXUCZ010000005.1  88863091-88863523   c
            2767-2998           JAXUCZ010000005.1  88858297-88858528   c
            2999-3130           JAXUCZ010000005.1  88855227-88855358   c
            3131-3704           JAXUCZ010000005.1  88849516-88850089   c
            3705-3937           JAXUCZ010000005.1  88847494-88847726   c
            3938-3986           JAXUCZ010000005.1  88840480-88840528   c
            3987-4165           JAXUCZ010000005.1  88837752-88837930   c
            4166-4285           JAXUCZ010000005.1  88833532-88833651   c
            4286-4402           JAXUCZ010000005.1  88830175-88830291   c
            4403-4592           JAXUCZ010000005.1  88827768-88827957   c
            4593-4717           JAXUCZ010000005.1  88826829-88826953   c
            4718-4966           JAXUCZ010000005.1  88825474-88825722   c
            4967-5044           JAXUCZ010000005.1  88823666-88823743   c
            5045-5310           JAXUCZ010000005.1  88822582-88822847   c
            5311-5454           JAXUCZ010000005.1  88819717-88819860   c
            5455-5581           JAXUCZ010000005.1  88812938-88813064   c
            5582-5628           JAXUCZ010000005.1  88807902-88807948   c
            5629-5720           JAXUCZ010000005.1  88807402-88807493   c
FEATURES             Location/Qualifiers
     source          1..5720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..5720
                     /gene="Cdk5rap2"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
     exon            1..227
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="Cdk5rap2"
                     /note="upstream in-frame stop codon"
     CDS             169..5685
                     /gene="Cdk5rap2"
                     /note="isoform 3 is encoded by transcript variant 3; CDK5
                     activator-binding protein C48"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2
                     isoform 3"
                     /protein_id="NP_001423548.1"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
                     /translation="MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVL
                     PIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKK
                     NIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELL
                     TKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEE
                     KDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEE
                     RQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEESENC
                     EAALAEKEALLAKLHSENVTKNTENHRLLRNVKKVTQELNDLKKEKLRLERDLEEAHR
                     EGNRGARTIHDLRNEVEKLRKEVCEREKAVEKHYKSLPGESSSKFHSQEQVVKGLTES
                     ASQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSPDSKLIFSKEK
                     QQSEYEGLTGDLKTEQNVYAHLAKNLQDTDSKLQAELKRVLALRKQLEQDVLAYRNLQ
                     TALQEQLSEIRKREEEPFSFYSDQTSYLSICLEEHSQFQLEHFSQEEIKKKVIDLIQL
                     VKDLHADNQHLKKTIFDISCMGVQGNDRLESTKQAEIMEDYAEGGGKDGYVRHMDSNI
                     LDHDGAHTPDTSEDHSLEDELLSLLATFFSKKATPSLESRPDLLKALGALLLERICLA
                     EQGSPGDHSDSKAEKALEQVAVRLRDELGHSCLANSFSKSHSELKSPRGTWLVKTGDE
                     AKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPEEAVFSTELESEALGEMPGLQAT
                     HLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQLQGQVLELQKELKEYK
                     IRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEGHETTHSAG
                     RDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSKSQLSVKV
                     SVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAIITVLCGT
                     EGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLESLKQQLVE
                     QEQELQKEQDLNLELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQIKDSHDI
                     CVVCHQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLEKLFLHGKSARV
                     EPHTQTELLRRLRTEEDNLPYQHLLPESPEPSASHALSDDEMSEKSFLSREPKPDSET
                     EKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGCETDQGSTNVS
                     AYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEKLRESLARKTESLEHLQL
                     EYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQQLLLQKDELL
                     QSLQMELKVYEKLAEEHQKLQQESRGEACGGGQKGQDPFSNLHGLLKEIQVLRDQAER
                     SIQTNNTLKSKLEKQLSQGSKQAQEGALTLAVQALSVTEWSLQLDKHDVNKCPEASDN
                     SFDLFESTQAMAPKSASETPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKS
                     GHHMLCLIEDYDALYKQISWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLS
                     SMNTAKLILEKASRLLKLFWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKL
                     QNTAKLLQQSKHQEKIIFDQLVITHQVLRKARGNLELRPRAAHPGTSSPSRPGS"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    604..>1581
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    604..>1581
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <4237..>4917
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <4237..>4917
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            228..295
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..363
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..830
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..993
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1035
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1155
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1374
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1545
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1686
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1784
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1909
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2019
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2148
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2333
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2766
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2998
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3130
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3704
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3937
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..3986
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4165
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4285
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..4402
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4592
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4717
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..4966
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5044
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5310
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5311..5454
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5455..5581
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5582..5628
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5629..5720
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccggga aagatggcgg cggctgcggt ttgaattcca gcggcgccgc ttgactgaga
       61 acaagagctg ggttggaggg ggcgggacct ggggaaccga gcgcgccgcg actgcggggt
      121 aaccagtggc gctgctgctg cagacaccgg tgccacctct ttgtgttcat gatggactca
      181 gggatggaag aggacgtcac cctgcctggg accctcagcg gctgcagtgg ccttcaccct
      241 gttctaccaa gtgatctgga tgtcatcagt gacactactg gcttgggaaa tggagtgctc
      301 ccaatcatgt cagaagaaaa ggtctctccc accagagccc ggaacatgaa ggactttgaa
      361 aaccaaatca ctgagctgaa gaaggagaac ttcaatctaa agctccggat ctacttcctt
      421 gaggagagga tacagcagga gtttgctggc cccacagagc acatctacaa gaagaacatt
      481 gaactcaagg tggaagtgga aagtctgaag cgtgagctcc aggagagaga tcagttgctc
      541 gtcaaagcct ccaaagccgt ggagagccta gcagaagggg gtggttctga aatccagcgg
      601 gtgaaagaag atgcaaggaa gaaggtgcag caggtggaag aactcctaac taaaaggata
      661 catcttctag aagaagatgt gaaagccgcc caagcagaac tggagaaggc ctttgcaggg
      721 acagaaacag agaaggctct tcggctcagc ttagaaagca agctctcggc gatgaagaag
      781 atgcaggagg gggacctgga gatgactctg gctctggaag agaaggacag actgattgag
      841 gagttgaagc tgtctttgaa gagcaaagaa gctttaattc agtgccttaa agaggaaaaa
      901 tctcagatgg catctcctga cgagaacgtg tcatctggag aactccgagg actttctgcc
      961 actctaagag aagaaaaaga gagagacgct gaggaacggc agaaggagag aaaccacttt
     1021 gaagagagga tccaggcact tcaggaggac ctgagagaga aggaaagaga aattgctaca
     1081 gagaagaaaa atagcttaaa gagggataaa gccattcagg gtctaaccat ggcattaaaa
     1141 tcaaaggaaa aagaggagtc tgagaactgt gaggctgcgc tggcagagaa ggaagccctg
     1201 ttggccaagc tgcactcgga aaatgtcaca aagaatactg agaaccatag gttgctcagg
     1261 aatgttaaaa aggtcaccca ggagttgaat gacctgaaga aggagaagct gagactagag
     1321 cgggacctgg aggaagccca ccgagaaggg aacagaggag cccgaaccat ccatgacctt
     1381 agaaatgaag ttgagaaact acgcaaggaa gtgtgtgaga gagagaaggc tgtggagaag
     1441 cattacaaga gtcttccagg cgaaagcagt tcaaagttcc attctcaaga acaagtggtc
     1501 aaaggtctga cagaaagtgc cagtcaggag gacctgctgc tgcagaaatc caatgaaaaa
     1561 gatttggaag caatacagca gaactgttat ttaatgactg cagaggagct caagtttggg
     1621 agcgatggct taataacaga aaagtgttct cagcagtcac cagacagcaa actcatcttc
     1681 tccaaggaaa agcaacaatc agagtatgaa gggctgactg gggacttaaa gacagaacag
     1741 aacgtctatg cccatctggc aaagaatctg caggacacag acagcaaact gcaggctgaa
     1801 ttgaaaaggg ttcttgccct ccggaagcag ctggagcagg atgtgcttgc ctatcggaat
     1861 ctgcagacgg ccctgcagga gcagctcagt gaaattcgga agcgggaaga agagccgttt
     1921 tcattttata gcgatcaaac atcatatcta agtatttgcc ttgaagagca cagtcagttt
     1981 caattggagc atttttctca agaagaaatc aagaaaaagg tcattgacct catacagctt
     2041 gtgaaggacc tgcatgcaga caaccagcac ctgaagaaaa ccatttttga tatctcttgc
     2101 atgggtgtcc agggaaatga cagacttgag tcaacaaaac aagcagagat catggaggac
     2161 tatgctgagg gtggcggcaa ggatggatat gtaaggcaca tggattccaa tattttagac
     2221 catgatgggg cccacacacc tgatacctct gaagaccata gcctagagga tgagctcctg
     2281 agcctactcg ccactttctt cagtaagaag gctacaccgt cgctggagtc caggccggat
     2341 ctgctgaaag cacttggtgc cctgcttttg gaacggatat gcttggcaga acagggaagt
     2401 cctggagatc actctgatag taaagctgag aaggcacttg agcaagtagc tgttcggttg
     2461 agagatgaac ttggccattc ctgcctagcc aactcattct ccaagtcaca cagtgagctc
     2521 aagtcaccgc ggggcacctg gctagtaaag acaggtgatg aagccaaggt ggagctgaag
     2581 agtgtctcag tgcagaccat gaccatagag gacagcaccc gtggattcaa acctgagagg
     2641 aagagagaag cttgggcagg gaaaccagaa gaggccgttt tcagcactga gcttgagtca
     2701 gaggcgttgg gtgagatgcc agggctacag gccactcacc tctcattccc cagtgccatc
     2761 gacaaggatg accagaagac aggcttgctg atccaattaa aaacacctga gttattggaa
     2821 aatttgtata atcttcctgc ctcccaagag gtggtagctc aactccaggg ccaggttcta
     2881 gagctgcaga aagagctgaa agagtataag atccgcaaca agcaactcct tgataagcta
     2941 attctggcag aggcaatgat ggaggggatg gcagtgccca actctactcc ggtaaacgtg
     3001 cctgcagccc aggctgttgt gagaacagcc ttccaaggca agccaggcga gcaagaagga
     3061 catgaaacca cacattctgc cggaagagac aaggaagtag acagtgacca atatacaagc
     3121 tttgagattg attctgaaat ctgcccacct gatgaccttg ccttattacc agcatgcaaa
     3181 gagaaccttg aagacttctt aggcccaccc tccatagcca cttacctgga ttccaagagt
     3241 cagctctctg ttaaagtcag tgtggttgga actgaccagt ctgagaatat caatctccct
     3301 gatgatacag aagccttaaa acagaaaatc catgacttgc aaactgagct ggaaggctac
     3361 cggaacatca ttgtccagct acagaagcat tctcagtgca gtgaggctat tattacagtt
     3421 ttgtgtggga cagaaggggc ccaagatggc ctgaacaagc ctaagggcca catcgatgaa
     3481 gaagagatga cattttcaag tttgcaccaa gtaagatatg tgaagcacat gaaaatcctc
     3541 cgtccactaa ccccagaaat aattgatggc aagatgctag agagcctcaa gcagcagctg
     3601 gtagaacagg agcaggagct acagaaggag caggatttga acttggaact tttcggtgaa
     3661 atccataacc tgcagaacaa gttccgagac ctctcgccat caagatacga ttcattggtt
     3721 cagtcccaag caagggagct ctctcttcag cggcagcaaa ttaaggatag tcatgatatc
     3781 tgtgtcgttt gccatcaaca catgagcacc atgatcaagg catttgagga acttctgcag
     3841 gccagtgatg tggacagttg tgtggctgag ggcttccgcg agcagctaac acagtgtgct
     3901 ggactgctag agcaactgga gaagctgttt ctccatggaa agtcagccag agtggaacca
     3961 catacccaga ctgaactgct aaggaggtta agaactgaag aagacaactt accttaccaa
     4021 catctcctgc ctgaatctcc tgagccttct gcctctcatg ctctgtcaga tgatgaaatg
     4081 tctgagaagt ccttcctgtc cagagaaccg aagccagaca gtgagactga gaagtaccca
     4141 acaatagcga gccgttttcc tcaagactta ctaatggaac acatacagga aattcgaact
     4201 ttgagaaagc atttggaaga atctattaaa acaaatgaga agctccggaa acagctggaa
     4261 cggcagggat gtgagactga ccaaggctct acaaatgttt ctgcttacag ctcagaactg
     4321 cataattctc tgacatcaga aatacagttc ctgaggaagc agaatgaggc cctcagtacg
     4381 atgctcgaga aggggtccaa agaaaaacag aaagagaatg aaaaattgcg tgagtccctg
     4441 gccaggaaga ctgagagtct tgagcacctt cagctagagt atgccagtgt aagggaagaa
     4501 aatgaaagac tgcggagaga catcagtgag aaggagagac aaaaccagca gttgactcag
     4561 gaggtctgca gcagcctcca agagctgagc agggtacagg aagaggcaaa gtcaagacag
     4621 cagctgctct tacagaaaga cgagctgctt cagtccctcc aaatggagct taaggtgtat
     4681 gagaagctgg ccgaggagca tcagaagcta cagcaagagt cccgaggtga ggcatgtgga
     4741 ggaggccaga aggggcagga tcctttcagc aacctgcatg gtctcctgaa agagatacag
     4801 gttctccgag accaggcaga aaggagcatt caaactaaca acacactgaa gagcaagctg
     4861 gagaagcagc tatcacaggg gtcaaagcag gcccaggaag gggccctcac tttggctgtt
     4921 caggccctgt ctgtcactga gtggtccctt cagttggaca aacacgatgt caacaaatgt
     4981 cctgaggcca gcgataattc atttgatcta tttgaatcta cccaggcaat ggcacctaaa
     5041 tcagcttctg agactcctgt cctttctgga actgatgttg attccctctc ctgtgacagt
     5101 accagttctg ccaccagccc ctcttgcatg ccctgcctgg ttgctggccg ccacctgtgg
     5161 gccagcaaga gtggccacca catgctgtgc ctgattgagg actatgatgc cctctataag
     5221 cagatcagct ggggccagac actgcttgcc aagatggata ttcaaaccca agaggctctg
     5281 agccccacaa gtcagaagct gggaccaaag gcttcattct ctgtgcctct gagcaagttt
     5341 ctctccagca tgaacacagc caagctgatc ctggaaaaag cctccaggtt gctgaagctc
     5401 ttctggaggg tctctgtccc caccaacggc cagtgttccc ttcactgtga ccagattgga
     5461 gaaatgaagg cagagatcac caaactacac aaaaaattgt ttgaacaaga aaagaagctg
     5521 cagaacacag caaaacttct gcagcagagc aagcaccagg agaaaatcat ctttgatcag
     5581 ttggtcatca cccaccaagt ccttcggaaa gccaggggaa acctggagct caggcctaga
     5641 gctgcccatc caggaacatc cagtcccagc agaccgggct catgagaaga gctttcagct
     5701 aataaagctt gtgatcctga
//
LOCUS       NM_001436641            6898 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus PLAG1 zinc finger (Plag1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436641 XM_063287275
VERSION     NM_001436641.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6898)
  AUTHORS   Gu,Q. and Wei,H.F.
  TITLE     PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of
            Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin
            Signalling Pathway
  JOURNAL   Folia Biol (Praha) 68 (1), 25-32 (2022)
   PUBMED   36201855
  REMARK    GeneRIF: PLAG1 Promotes High Glucose-Induced Angiogenesis and
            Migration of Retinal Endothelial Cells by Regulating the
            Wnt/beta-Catenin Signalling Pathway.
REFERENCE   2  (bases 1 to 6898)
  AUTHORS   Hide,T., Takezaki,T., Nakatani,Y., Nakamura,H., Kuratsu,J. and
            Kondo,T.
  TITLE     Sox11 prevents tumorigenesis of glioma-initiating cells by inducing
            neuronal differentiation
  JOURNAL   Cancer Res 69 (20), 7953-7959 (2009)
   PUBMED   19808959
REFERENCE   3  (bases 1 to 6898)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
REFERENCE   4  (bases 1 to 6898)
  AUTHORS   Voz,M.L., Agten,N.S., Van de Ven,W.J. and Kas,K.
  TITLE     PLAG1, the main translocation target in pleomorphic adenoma of the
            salivary glands, is a positive regulator of IGF-II
  JOURNAL   Cancer Res 60 (1), 106-113 (2000)
   PUBMED   10646861
REFERENCE   5  (bases 1 to 6898)
  AUTHORS   Astrom,A.K., Voz,M.L., Kas,K., Roijer,E., Wedell,B., Mandahl,N.,
            Van de Ven,W., Mark,J. and Stenman,G.
  TITLE     Conserved mechanism of PLAG1 activation in salivary gland tumors
            with and without chromosome 8q12 abnormalities: identification of
            SII as a new fusion partner gene
  JOURNAL   Cancer Res 59 (4), 918-923 (1999)
   PUBMED   10029085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063287275.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.213675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  21754093-21754272   c
            181-290             JAXUCZ010000005.1  21739478-21739587   c
            291-395             JAXUCZ010000005.1  21718307-21718411   c
            396-495             JAXUCZ010000005.1  21710736-21710835   c
            496-854             JAXUCZ010000005.1  21706208-21706566   c
            855-6898            JAXUCZ010000005.1  21699650-21705693   c
FEATURES             Location/Qualifiers
     source          1..6898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..6898
                     /gene="Plag1"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
     exon            1..180
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..290
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..395
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..495
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..854
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    604..606
                     /gene="Plag1"
                     /note="upstream in-frame stop codon"
     CDS             613..2112
                     /gene="Plag1"
                     /note="isoform a is encoded by transcript variant 3; zinc
                     finger protein PLAG1; pleiomorphic adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1 isoform a"
                     /protein_id="NP_001423570.1"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
                     /translation="MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFN
                     SVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKC
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDD
                     GAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHS
                     SVSQLPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ"
     misc_feature    613..711
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    616..864
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Interaction with KPNA2. /evidence=ECO:0000250"
     misc_feature    676..687
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    718..780
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    718..780
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    733..1338
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Decreased nuclear import with localization in the
                     nucleus but also in the cytoplasm. /evidence=ECO:0000250"
     misc_feature    order(733..735,739..741,745..747,751..756,763..768,
                     775..777,823..825,829..831,841..846,853..858,865..867,
                     907..909,913..915,919..921,925..930,937..942,949..951)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(733..735,739..741,745..747,751..756,763..768,
                     775..777,823..825,829..831,841..846,853..858,865..867,
                     907..909,913..915,919..921,925..930,937..942,949..951)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    <784..1029
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <784..1029
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    802..870
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    802..870
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    847..915
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    847..915
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    892..954
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    892..954
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    979..1041
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    979..1041
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1066..1128
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1066..1128
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1081..1083,1087..1089,1093..1095,1099..1104,
                     1111..1116,1123..1125,1186..1188,1192..1194,1204..1209,
                     1216..1221,1228..1230,1270..1272,1276..1278,1282..1284,
                     1288..1293,1300..1305)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1081..1083,1087..1089,1093..1095,1099..1104,
                     1111..1116,1123..1125,1186..1188,1192..1194,1204..1209,
                     1216..1221,1228..1230,1270..1272,1276..1278,1282..1284,
                     1288..1293,1300..1305)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1171..1233
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1171..1233
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1255..1311
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1255..1311
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1339..2109
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Activates transcription, Inhibition of nuclear
                     import due to lack of NLS and KPNA2 interaction.
                     /evidence=ECO:0000250"
     misc_feature    1339..1761
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Repression domain, contains 3 sumoylation motifs
                     and massively decrease transcription activity.
                     /evidence=ECO:0000250"
     misc_feature    1702..1812
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1762..2109
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Massively activates transcription.
                     /evidence=ECO:0000250"
     exon            855..6898
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgcaagt tgagctgcag gggcagcgca tacactacaa tggctgctgg aaagaggcgt
       61 aaggaaacaa tttccaggcc cgccgcgtcc agcccgaaat atgagaaaaa aattattaga
      121 aattccgcgg gcggtgtaaa ggcggcggac gggccggagg gaggatgtta aagccccgcg
      181 tcacctggtg tcatccttac atttgccatt gatctaggac tgctaatcgt ccctgtactc
      241 caaatcccat tgtccaacct actgttctac ccaaaaggct gattcagaag gttgcctctc
      301 agtgctgcct tggtggtatt gggcacccag aatgcttcag tctgtaatga tctattaata
      361 aggtggccta actagagttt gcagcagggt ctcagattgg ccaaaatggg aagggatgga
      421 ttctgctctc ttccacgaag agttaatggg actggctaag atcaaagtct gaggcttttt
      481 tccatcacta atcagtccct ttttgctttc ttttacgacc acatgaaact tgagaagcca
      541 cctaaagcta aatcacttag tggagttggg cagttcccag gtgtccaacg agaaggcctg
      601 gtttaggctg cgatggccac tgtcattcct ggtgatttgt cagaagtaag agatacccag
      661 aaagcccctt cagggaaacg taagcgtggt gaaagcaaac caagaaaaaa ctttccttgc
      721 caactgtgtg acaaggcctt taacagtgtt gagaaattaa aggttcactc cttctctcac
      781 acgggagaga ggccctacaa gtgcacacac caagactgca ccaaggcctt tgtttctaag
      841 tacaaattac aaaggcacat ggctactcac tctcctgaga aaacccacaa gtgtaattat
      901 tgtgagaaaa tgtttcaccg gaaagaccat ctgaagaacc acctccatac acacgacccc
      961 aacaaagaga cttttaaatg cgaagagtgt ggcaagagct acaacaccaa gcttgggttt
     1021 aagcgacact tggccttgca cgctgccacc agtggcgacc tcacctgcaa ggtgtgtttg
     1081 cagacttttg agagcacagg tgtgctccta gagcacctga aatctcacgc aggcaagtcc
     1141 tctgggggcg tgaaagagaa aaagcaccag tgtgagcact gcgagcgcag gttctacacc
     1201 cggaaggatg ttcggagaca catggtggtg cacacgggaa gaaaggactt cctctgtcag
     1261 tactgtgcac agagatttgg acgaaaggat cacctcactc gacacatgaa gaagagtcac
     1321 aatcaagagc ttctgaaggt caaaactgaa ccagtcgatt tcctggaccc attcacctgc
     1381 aacatgtctg tgcctataaa agatgagctc ctgccggtca tgtccttgcc ttccagcgaa
     1441 ctcttgtcaa agccattcac caacactttg cagttaaacc tctataacac tccatttcag
     1501 tccatgcaga gctctgggtc tactcaccaa atgataacaa ctttaccttt gggaatgacg
     1561 tgccccatag atatggacac tgttcacccc tctcatcatc ttgctttcaa atgcccgttc
     1621 agttctacct catacgcaat ctctattccc gagaaagaac agcccttaaa gggggaaatc
     1681 gagagttatc tgatggagtt acaaggtggc gcaccatctt catcccagga ttctcaagca
     1741 tcatcgtcta agttagggtt agagcctcag agtggctccc cagacgatgg tgctggggac
     1801 ctctccctgt caaagagctc tatctctatc agtgaccccc tgaacacacc agcattggat
     1861 ttctctcagt tgttcaattt cataccatta aatggtcctc cttacaatcc gctctccgtg
     1921 ggaagccttg ggatgagcta ttcccaggac gaggcgcatt cttctgtttc tcagctgccc
     1981 acacaaacac aggatcttca ggatcctgcg aacacagtgg gccttggctc tctgcactca
     2041 ctgtcagcag ctttcaccag cagcctaagc tcaagcacta ccctgccccg tttccaccag
     2101 gcctttcagt agggtctggg ccgagggatt caccggaggt gcttgtgcag ccccgcctgc
     2161 aaagaccatt tatattctag tgcctacttt aacacaacac agaaacttct ccttttgtat
     2221 aatatcaggt tttatgaagc cagtaaatag gaattagcct ctttgataag ctttgaaatg
     2281 gttcgtgttt aactacgttt gctgtttctc ctgatttcct gccagttgtc atagtctcgg
     2341 agttttattt catagaggag cgccattatt atcactaaat tttacaagtc ctgtgttcaa
     2401 attactgtta gaccttaaca ttctcacttt tgtctaatag caatgggcat tggacttttt
     2461 tttttttgca aatgtgcagt acaatgtaaa tcttctatga aatgtgtgtg aagaactgaa
     2521 gtgtttcaca tttctttact agccactaaa tggattcata atcaagtgtg ttttaaatga
     2581 gttaagaatc cagtttgggg agagtatagt ggtttcctaa atacaccatc atttgagatc
     2641 aatatatttt gaagactgct attgtctggc taaaataaga agtttcagta tctatttaat
     2701 agaaacctag agatgttacg gggtgttctg tgttagaact agccctcagg ctgatttgcc
     2761 acatttcaac catctttccg ttaacagtgt gtggcctcgg agtcttcagg atcagtgtag
     2821 aagtgttctg ttgtatgccc ttcacctttc ataccccagg atggcttcac aataccagca
     2881 ttcttacttt gcatgttggt ccagttagtg cagagtctta gaaccattgt gggacaatag
     2941 acagtaaata tatgaagccc agagtggctg gctgcctgaa tcgtcggggt gatagactcc
     3001 tcaccaggaa gatggatgta aaacgtacag ccaaacccca gcacttgtct agagaatgtc
     3061 cactgttgcc agaactgaga actggactcc tatcgcatca cttctaaaac agcagtcttg
     3121 cccgtgcgcc cttgctcagt gcatatacat ctttccctgc cgtgtttgga tggagaactt
     3181 aaaaattaaa cacatcaaaa agcaacttga cgagttccac agttttacac caccaaaagt
     3241 tgttaagagc ccacttttac acatctccag gagacaggag gaatgttaga aataagttga
     3301 atttatagag gaaacagagg aaaataaagc aaacaccaaa tgaatacgaa tgcaccaagg
     3361 atgtggtgct cactgagcaa ggtagcaatg ggcttcctct tgtcagacag ccaccaagaa
     3421 tgtcatcggt agctccgcgt atatcttcct aagggttatt tgtggcatca acctacgaga
     3481 cttactaagc acttgttaac accttattct ggaccccttc tgttggggca gggagtttta
     3541 tagaagagta tatatctctt taaaaaaaaa aaaaaggaag aaactatttt ttaatctctg
     3601 agcactcgtt agccctggct ggggaagctt cttcccttgt gtaagggcca gttatcactg
     3661 catattgtat tgtttaccca tcactctaag cataaacaga ttactgacta tgatgcatta
     3721 tttacaatgc ctgggagtag tctaaattga gaagtgtaaa ctgtcctgtg aatggggctt
     3781 tcactatatg tcatacacac gcctagtgca cttcatagaa tcagagctgc tccctagagg
     3841 gctcaagctc ctggttctaa ccctagagca gtagttttta tacgtatgta tttaaatttt
     3901 attgtgaaaa atacatttta ttaaagaaag tgttccaaag gcattaaaat tatatacgtt
     3961 aataaggaaa tacattttaa ctcttcaagc tgctcctgag ctgagggtgg gagcgcactc
     4021 actcagaaag tgggctcttc gcatgaccgc ttccttagtt tctatgaaac cgatcacgta
     4081 ccctaatgtt ctagttggat gattagtgtt caatattgct ttaatcacca cttttaaaag
     4141 gagaggacat ttggtgacag agcacaagta aataaaaaaa cctattatta tgtagagttc
     4201 acagacacca catatgaaag cactagttta ttctatctaa aaattactta agaagtcaca
     4261 tttatgacct gagacgttgg ccttcgtagg ctgtatatat ttcactgcta attgaaaaaa
     4321 gggagtacca ggatatatga aataaagcat ttcgcaatgg gaatggcgcc atatatgtgt
     4381 gtgtgtgtat atatatatat atatgtatgt atatatatat atataataaa tatattttta
     4441 tcctaattct tgcccagcgc agaactctaa tacacatctt ccagggtacc agtgttaaaa
     4501 cgtagagtct tactttcctt tgtatgtaca cctctttgcc tgttgctgcc cccacagact
     4561 tgaatgacat ttcaaagtaa gagggaaata agcaaattct tttcgcttta ttgactgcag
     4621 tggtcactaa accctttttt gatagatttt atattaaaaa tcagtcagct tttttatttt
     4681 cattgcacaa tgttttaaca ggaacgcaac acagaattgg caacccctac cccatggaaa
     4741 atactgtcac tcgttctgtc tgaagtagga ctgcttagca ataggccttg ctagtgccct
     4801 tctcattctc catggtcctc gggatttctg atagtgcctt agcttaaaag aaaaggggtt
     4861 aacattaact aaacagtgta gtgtagagtt tggacctcag acaagatgct gggccccgtt
     4921 cattttgact tccacacatg tgtgtgcagc ttcaggagtg tgagcgcctt ttcaggaaag
     4981 gtctggcact gtgagcaata tagtccattg atatttacca ataaatacca cctctgtagt
     5041 taatgtctct taagcttccg tttaaaatcc cgttacttgt tgaggtttct aaaatgtaag
     5101 ttgccttggc agatcatgca ccagtctgtg tgcagctttt ttcccttttt aatttcagtt
     5161 ggcgtttctt tcaagctgtg tgtgtttgcc tatgtgtcgc ttgcgcttta tttttctagt
     5221 catttgtgga atatagtgat atattgtgtt aatttggaca gtgacggttt tttgaaacca
     5281 tatactgact gaaacatgag ccagagctga ttgctttatt aagctaataa tgaatgttat
     5341 agagtacata tttcaggatc attcatctag tgagcagtac acatataggc caattaaaaa
     5401 aaaatagagc ttggtcaacc tctatacttc acatactaca agatatagca ctttcaaaat
     5461 gaacctaaat ttctacagaa actttcctat atgttatgcc ttttattttt aagacttatt
     5521 atattcattt caagtgccat tagacgatat atccgtaggc ctttgatata taatgctttg
     5581 tgtacaaaga atagtagatg gtattttaaa caggtacatt tttacagtgt tttcctatcg
     5641 atttgctata ttgcacagaa tcagtgtgtg tcctttcata aggttttaca atggtttatt
     5701 tttttacaag gtttacgtat ctcaaagcac actgtcttcc cagtccataa gtaagttaaa
     5761 agataccagt tcacccaagt tgcttctagc ctactgcgat ccatgtgaca ttgaaggaga
     5821 tctttgcagt gttgaatatt cgcccttcat gaaggcaggc tggttttttt tcctgacaaa
     5881 tgagttcgtt ggtgaatttg tctcgtttta ctcatgatgt cagcagccgg gtctaccaca
     5941 caacatagct tgattgtgta agcctccgta aataccttaa attgtattgt acccacagag
     6001 cactcctctg agattaagca agctaatgcc atcagccttc atagcaggca cggatcacca
     6061 ataagccttt ctacaatgtt agcagcccct ggagatggaa ggcagtgtct tttgataagt
     6121 tatctatctc tatagatgac acaggattat tactgatgta taagacactt cattgtataa
     6181 gcttcagtgg tacagatgaa ccagaatgaa tgtctgtctt ctcagaagcc ctccttcaac
     6241 gttctatggg atcatgctgc tactgtcact tgggatacaa ctcttcatgg tgctacaaac
     6301 ttctgtctca ttcacttgta tttttttacc cataggaaaa ggactctata ggtgtaaagg
     6361 tgtacaatat atttttatac tgtgacttaa attgtcatta acaaactttt acaccaccac
     6421 agtgtactca tgtgcgcttg caaaaggaga tcttggatgt gcaaatgtta ccagaacaaa
     6481 cccagctttt gtccacaagg tgactgtaac tcagaatgga aagtgagctt gacatagggt
     6541 gtggagtgaa gaacatgcta taagttacta acagcccttt gaatttaaca aaaactggga
     6601 atccattaga gaaatggatt gcatcatgcc tgaacataag ctgactgctg aaatattttt
     6661 ttttagctaa tgaaaaagtg tttggactag tgtactctaa aaaatgtttt aatggtaaag
     6721 ttttgagtca aatagaaatg aaaaaaaatc tgcattccag acttaatttt gtatattttt
     6781 attgcctttt aaattgctat tctgtgatat tgggaaatca agtggcttat catgtatatc
     6841 atgtacttaa aatgtattca caaactactg ttgtatttgt ataaaatata gacaaaga
//
LOCUS       NM_001436634            4584 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus MYB proto-oncogene like 1 (Mybl1), transcript
            variant 4, mRNA.
ACCESSION   NM_001436634
VERSION     NM_001436634.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4584)
  AUTHORS   Zhang,D., Xie,D., Lin,X., Ma,L., Chen,J., Zhang,D., Wang,Y.,
            Duo,S., Feng,Y., Zheng,C., Jiang,B., Ning,Y. and Han,C.
  TITLE     The transcription factor SOX30 is a key regulator of mouse
            spermiogenesis
  JOURNAL   Development 145 (11) (2018)
   PUBMED   29848638
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4584)
  AUTHORS   Li,X.Z., Roy,C.K., Dong,X., Bolcun-Filas,E., Wang,J., Han,B.W.,
            Xu,J., Moore,M.J., Schimenti,J.C., Weng,Z. and Zamore,P.D.
  TITLE     An ancient transcription factor initiates the burst of piRNA
            production during early meiosis in mouse testes
  JOURNAL   Mol Cell 50 (1), 67-81 (2013)
   PUBMED   23523368
REFERENCE   3  (bases 1 to 4584)
  AUTHORS   Bolcun-Filas,E., Bannister,L.A., Barash,A., Schimenti,K.J.,
            Hartford,S.A., Eppig,J.J., Handel,M.A., Shen,L. and Schimenti,J.C.
  TITLE     A-MYB (MYBL1) transcription factor is a master regulator of male
            meiosis
  JOURNAL   Development 138 (15), 3319-3330 (2011)
   PUBMED   21750041
REFERENCE   4  (bases 1 to 4584)
  AUTHORS   Ma,X.P. and Calabretta,B.
  TITLE     DNA binding and transactivation activity of A-myb, a c-myb-related
            gene
  JOURNAL   Cancer Res 54 (24), 6512-6516 (1994)
   PUBMED   7987850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.3324022.1,
                                           SRR21887622.3324023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000005.1  14365754-14366144
            392-497             JAXUCZ010000005.1  14374290-14374395
            498-569             JAXUCZ010000005.1  14374701-14374772
            570-662             JAXUCZ010000005.1  14377334-14377426
            663-883             JAXUCZ010000005.1  14379756-14379976
            884-1058            JAXUCZ010000005.1  14381472-14381646
            1059-1130           JAXUCZ010000005.1  14384029-14384100
            1131-1235           JAXUCZ010000005.1  14385306-14385410
            1236-1469           JAXUCZ010000005.1  14388742-14388975
            1470-4584           JAXUCZ010000005.1  14390071-14393185
FEATURES             Location/Qualifiers
     source          1..4584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4584
                     /gene="Mybl1"
                     /note="MYB proto-oncogene like 1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
     exon            1..391
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    366..368
                     /gene="Mybl1"
                     /note="upstream in-frame stop codon"
     CDS             372..1892
                     /gene="Mybl1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     myb-related protein A; myeloblastosis oncogene-like 1"
                     /codon_start=1
                     /product="myb-related protein A isoform 4"
                     /protein_id="NP_001423563.1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
                     /translation="MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDD
                     KLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV
                     QKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNR
                     WAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHL
                     QTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMS
                     AENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQN
                     SPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDLSDAAASPVKSTPV
                     KLMRIQHNEGAMECQFNVSLVLEGKKNSCNGGDSEAIPLASPNVVKFSTPPTILRKKK
                     RLRVGQSAGSELGEGSLSEGNNAALKHTPVKTLPFSPSQVLVLYVCQCWQATLTDL"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     exon            392..497
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..569
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..662
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..883
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1058
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1130
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1235
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1469
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..4584
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctgc tcgctgcggg gagagggcgg gggtcggcgc ccgtgacgga gccgcgcagg
       61 gccggcagct ccaaggcgga ggcggaggcg gcgggagggg cgggcggagg gcgggagcac
      121 ggctcctgac atgtccaggg catccctggc cgggccgggc cgcggctagg agcagcgggt
      181 cttggtccgc ccctctgtcc ctcagtcccg cctggccctg acctgtcggg gcctgcgttc
      241 cgctctctcg gccacctgag ggaaggagcg gggtaagcgg cgggtgggtc tcggagaggg
      301 cgcactcgcc ccaggctgga ggaggctgac ccgcgtcccc gcccagcccg cgcctatgcg
      361 gtacttgaag gatggcgaag aggtcgcgca gtgaggatga ggacgatgac cttcagtatg
      421 ctgatcatga ttatgaagta cctcaacaaa aaggactgaa aaaactctgg aacagagtaa
      481 aatggaccag agatgaggat gacaagttaa agaagttggt tgaacaacac ggaactgatg
      541 attggactct aattgctagt catcttcaaa atcgttctga ttttcagtgc caacatcgat
      601 ggcagaaggt tttaaatcca gaattgataa agggtccttg gacgaaggaa gaagatcaga
      661 gggttattga attagttcag aaatatgggc caaaaaggtg gtctttaatt gcaaaacatt
      721 taaaaggaag aataggcaag cagtgcagag aaagatggca caatcacctg aaccccgagg
      781 taaagaagtc ttcttggaca gaggaagaag acaggatcat atacgaagcg cacaagcggc
      841 tgggaaaccg ttgggccgag attgcgaagt tacttcctgg aaggactgat aattctatca
      901 aaaatcattg gaattctacc atgagaagaa aagtggagca ggagggctac ttacaagacg
      961 gaataaaatc agagcggtct tcatccaaac ttcaacacaa accttgtgcg actatggacc
     1021 atttgcaaac ccagaatcag ttttacattc ctgttcagat ccctggttat cagtatgtgt
     1081 cacctgatgg caattgtgtt gaacatgtcc agacatctgc ctttattcag caaccctttg
     1141 ttgatgaaga tcctgataaa gagaaaaaaa taaaggagct cgagttgctt cttatgtcag
     1201 ctgagaatga agttagaaga aagaggcttc cacctcaacc tggaagcttt tctagctggt
     1261 ctggtagttt cctcatggat gatagtatgt ctaacacgct gaataatctt gaggagcaca
     1321 ctactgagtt ttatagcatg gatgaaaatc agactgtttc tgcccagcag aactcaccca
     1381 caaagtttct agctgtagaa gcaaatgctg tgctgtcctc tctacagacc atcccagaat
     1441 ttgcagaaac tctagaactt attgaatcgg atcctgtagc atggagtgat gttaccagtt
     1501 ttgatctttc tgatgctgct gcttctcctg tcaagtctac tccagttaaa ttaatgagaa
     1561 ttcagcataa tgaaggagcc atggaatgtc aatttaacgt cagtcttgtc cttgaaggga
     1621 aaaagaacag ttgtaatggt ggagacagtg aagctattcc tttagcatcc ccaaatgtgg
     1681 tcaagtttag cactccacca actatcctca gaaagaagaa aagactacga gtgggtcagt
     1741 ctgcaggcag tgagcttggt gaaggctcac tcagtgaggg caataacgca gccctgaagc
     1801 acacaccagt aaaaacacta ccgttttctc cttcacaggt actagtgctt tatgtttgcc
     1861 aatgttggca agctacacta acagatctgt agtattttta aaagcaattg actgttttgt
     1921 taacacaaaa atatatgcta tgtttaaatg tatacacgag agtggtaaac cctgaaagta
     1981 cctcacaaaa ggtaatattt gcatcatagc accatagaat ttcaagagtt aaaagggagg
     2041 ttttctttgt catattgtcc tatttctgga taagattcct caggaaagtg atctctaaaa
     2101 agtaaaatga tttattttcc caaaggtctc tagtgcagaa ctaagactaa gatccagggc
     2161 gactctttga ttctcggttg tctgccatat attcctgaca tggtgtagag agacctgtct
     2221 acatacagca gtttagagtt tcatttacac ggtgattttc ccctttgaca ttctttggaa
     2281 gaactctaga tagcagttta ctctaagaat ctcctgtttt gatgcccacg agtacctgct
     2341 ttactcttta gtgatgttcc aagtagcaaa tgtacacatt aggattactt tttttattgg
     2401 gcacttgtta tattctaggc tgtgtgtctc ttttcttaca gcatctcctg ttaatcttct
     2461 ttcaaatgac attggaagtc aaaggaaata agttttgaaa tgcagcacct cctgtttgct
     2521 gaaagtgttt tgattatctt aatttctttc ctgttgctgt gatgaactag cctgacaagc
     2581 tatgtaaggg gggaagggta gggttatttt agcccccagt tccaggggac agtgtagtgg
     2641 aagtcacagt ggtaggactt gagacagcta ctcacgtcac tacccacagc aagaggaaag
     2701 cgatgaatgc ctgcgtgaat gcgtgctgct gttgtcgctc acctcatctc tgagaccttc
     2761 cagaatccgc tgctgctcgg ggaatggtcc ctccactttt aggctgagat tccccacctc
     2821 acttaaccta attaagggcc tcacaagctt gcatgagccc aattctcaga tgattctagg
     2881 ttttgtcaag ttggcagcat taatcatcca tcacacagat gttaaaaagt tttttgagtg
     2941 gctagagaga tggctcagtg gttaagagca ctgactgctc tcccagaggt cctgagttca
     3001 attcccagca accacatggt ggctcacaac catctgtaat gggatctatg ccctcttctg
     3061 gtgtgtctga agacagccat actgtactaa aataaatgaa taaataaata aatggataaa
     3121 tctttctaaa aaaaaagtgg tttttttgag agtaataggg aacttcatgg tcagatatgg
     3181 agaattctgg aatatttttg gaggtatatt ttaaggttgg gaaggtaagt aggctgtggt
     3241 agtacatagc cactgagatc taaaaatgtt tgaggtaata cagtttgcat tacaacatga
     3301 acgatatatt tattcttcct ctagctctca cagttcagaa ttatcccagg gaagatgagg
     3361 ttttctattt ccagagcttt atatgctagt aatttttact gaagtcagtt ctatgctaga
     3421 gagcaagtag atagtactta tatcccatga catttggaag agtttgatat ttaattctag
     3481 gtgaggtaat ttcaaatatt agaagacagg agagctggag cttgagtaga ttgcacttgt
     3541 aagtggcgct cctgaagaag cagcttctac ttcctcatat taccactgct agtctgctag
     3601 ctgcaaaagt aaatgagact tttttttttt attaacttga gtatttctta tttacatttc
     3661 gaatgttatt ccctttcccg gtttccgggc aaacatcccc ctagtccctc cccctcccct
     3721 tctttatggg tgttcccctc cccaccctcc ccccattgcc gccctcccca caacaatcac
     3781 gttcactggg ggttcagtct tagcaggacc aagggctttc acttatactg gtgatcttac
     3841 taggatattc attgctactt atgaggtcag agtccagggt cagtccatgt atagtcttta
     3901 ggtagtggct tagtccctag aagctctagt tgcttggcat tgttgttcat aaggggtctc
     3961 gagccccttt aagctcttcc agttctttct ctgattcctt caacgggggt cctattctca
     4021 gttcagtggt ttgctgctgg cattcgcctc tgtatttgct gtattctggc tgtgtctctc
     4081 agtagagatc tacatctggt tcctgtcggc ctgcacttct ttgcttcatc catcttgtct
     4141 aattgggtgg ctgtatatgt atgggccaca tgtggggcag gctctgaatg ggtgttcctt
     4201 ctgtctctgt tttaatcttt gcttctctat tccctgccaa gggtattctt gttccccctt
     4261 ttaaagaagg agtgaagcat tcacattttg atcatttgtc ttgagtttca tgtgttctat
     4321 gcatctaggg taattcaagc atttgggcta atatccactt atcaatgagt gcataccatg
     4381 tgtgtttttc tgtgattggg ttacctcact caggatgata ttttccagtt ccaaccattt
     4441 gcctatgaat ttcataaagg cattgttttt gatagctgag taatatgcca ttgtgtagat
     4501 gtaccacatt ttctgtatcc attcctctgt tgaagggcat ctgggttctt tccagcttct
     4561 ggttattata aataaggctg ctat
//
LOCUS       NM_001436610            5770 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 8, mRNA.
ACCESSION   NM_001436610
VERSION     NM_001436610.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5770)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5770)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5770)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5770)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5770)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5770)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5770)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5770)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5770)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5770)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.611775.1,
                                           SRR26360190.1326755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-325             JAXUCZ010000005.1  60611539-60611675   c
            326-367             JAXUCZ010000005.1  60609743-60609784   c
            368-634             JAXUCZ010000005.1  60609265-60609531   c
            635-694             JAXUCZ010000005.1  60607510-60607569   c
            695-921             JAXUCZ010000005.1  60605329-60605555   c
            922-1025            JAXUCZ010000005.1  60599244-60599347   c
            1026-5770           JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5770
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5770
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            189..325
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    269..271
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            326..367
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..1180
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform b is encoded by transcript variant 8;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform b"
                     /protein_id="NP_001423539.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEVA
                     ESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKIS
                     MKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGE
                     KVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLES
                     QAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    <368..493
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    <368..493
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    641..946
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    641..946
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    order(923..925,929..931,935..943)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(923..925,929..931,935..943)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    929..931
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    929..931
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    998..1171
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    998..1171
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            368..634
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            635..694
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            695..921
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1025
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..5770
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagag ccaagatgcg ggtgtgctgg ttggtgagac aggactgctg gcaccagcga
      241 atcaaacttc cccatttaga agctgttgtg attggtcgaa gcccggagac caagatcaca
      301 gataagaaat gttcccgaca gcaagttgaa agcggagtgt aacaagagat atgtcaacgt
      361 taagcagatg ggggtcaatc ccaccagcat tgacgaagtc gtcattggga aggaccggga
      421 gatgaagctg ctgcctggtc aggttctcca catggtgaat gaactttatc catacatggt
      481 ggagtttgag gaggtggcag agagccctaa cgtaacacag aggaagagaa agaggccaga
      541 ctgtgatagt caggagatgg aagctgaggc tggggccagc cccagccagt gctctgtgtc
      601 ccctaagacg ggcaagcatg gagccgccaa ggaggaatca ctgggccact ggagtcaagg
      661 cttgaagata tctatgaaag accccaaaat gcaggtttat aaggatgatc aggtggtggt
      721 gattaaggat aaatacccca aggcccggca ccactggctg gtcttaccat gggcctccat
      781 ttccagtctg aaggttgtga ccagtgaaca cctcgaactt ctcaaacaca tgcacgcagt
      841 aggggaaaag gtgatagcag attttactgg atccagcaaa ctgcgcttcc gactgggtta
      901 ccatgccatt cccagcatga gccatgtaca tcttcatgtg atcagccagg attttgattc
      961 tccttgcctt aaaaacaaaa agcattggaa ttctttcaat acagaatatt ttctggagtc
     1021 acaagctgtg atcaagatgg ttcaggaagc tggcagagtg actgttaaag atgggacttg
     1081 cgaactcttg aagctgcctc tccgttgcca tgagtgtcag cagctgctgc cttccatccc
     1141 acagctgaag gagcacctca ggaagcactg gggcgggtga cactcgcctt ggtgaccgag
     1201 tgcagtgcta gcatcattct gcattgcctg cgctccgttc agtcctgaac taaagcatgc
     1261 agctcttcaa aacaaagctt attattcttg agtgaccaca cagggtgact ctgggtcagg
     1321 aactgggaat atgggtttgt atggtatatt ttctggtaat ggaggatgag acatgcctga
     1381 tcactcttcc caagaccatg tcaggcctga ctaataagag ggcagagcca gcttgaggtt
     1441 caaatacaag atgtagaagc agaggactgg taatgtattt gttcctaccc ttgcccctgg
     1501 atcatgttct atctttttat caagatagct gaggttctga gggggcctgg ttcctgctct
     1561 atgatattcc tcttccctcc atgaggaggc tttcaatcta ctgtaccagg ctgagtgcct
     1621 gggtgaacat atgtggcagt catctgcaca gagagatact ttgtgtatga ctgtgccagg
     1681 gaactggaag tggtaatatt gggcacagta tgttaacagt acagcctgtg tcgagggcaa
     1741 actggggtaa tgtgaactgc cagtaaacag tacatcctct gctgagggca gcctggggca
     1801 gtgtgaactg ccagtaaaca gtacagcctg tgctgagggc agcatggaac agtgtgaact
     1861 gttagtgaac agtagtctgt tctgagggca gccttgtaca gtgatgtcag ttaacagtgc
     1921 agtctgttga gggcatcctg ggatggtgtg aactgtcagt taacagtgca gtctgttgag
     1981 ggcatcctgg gatggtgtga actgtcagtt aacagtgcag tctgttgagg gcatcctggg
     2041 atggtgtgaa ctgtcagtta acagtgcagt ctgttgaggg catcctggga tggtgtgaac
     2101 tgtcagttaa cagtgcagtc tgttgagggc atcctgggat ggtgtgaact gtcagttaac
     2161 agtgcagtct gtgttgaggg cagcctgggc agtgtgtatt gttagcttca ggcagatttt
     2221 acggaggctt cagccactgc tcttgagaat tacagaacat ttaactaaac ttcggataat
     2281 gtatcttaga aaaacagatg ttgcaaaata gttcatttac tttccacctg atacaatata
     2341 gtttagcaca tcagtattaa aatgagtatt tgctgtaaac tactaggagt gtctgtatca
     2401 gacagcgtaa gaatgtcagg tataatgaga aacatttggg gaatgaggtg accatgctta
     2461 cattcttcct tctgcccaaa atagattttt ttaagactgg ggtgagtgca tgctgccctt
     2521 cctaggacct gagttttgtt cccggcatcc atattaggtg gctcacagct gcctgtagct
     2581 ccagggatcc tgcacctgct tcttgacctc tgtgggcact gcattcaagt acacaaacct
     2641 gaatacagac acacattcac acataattaa atctgtaaaa atcagatctc gggctggaga
     2701 gatggctcag tggttaagag ctcctccaga ggtcctgagt tcaattccca gcaaccacat
     2761 ggtggctcac aaccatctgt aatgggatct gatgccctct tctggtatgc atggagacag
     2821 ccacagtgca cttatacata aataaataca taaataaaaa aaatagatct cttagaggaa
     2881 aaatgtcaat aatgactggc aggaagcagg tattgaggta ttgaggttta ttcattccct
     2941 agccctcctc tccgaaatgg gcttttatca ccatggggaa gaagactgtc tggactctgg
     3001 attacttgac agacatgtca ttgtacaatt agttgaagct ttccttcaga gtcagaggga
     3061 gggatgttgg gagactgcaa agtagaagaa agccagccac atttaaagct aggcacagtg
     3121 gcaaattctc ttgcaatccc aaatttagga ggtggtagat ccaggagggc caggcattcc
     3181 aggttatcct tgtctatatg gtgaacttga ggtctggact acatgagacc ctatgtcaca
     3241 gaagcaaata aataaaagat ttaaaaaggg gaaataaaat tctatctaag gtaccaaagc
     3301 atattatttg gcccatcatg gccaggcaag accagttgtt atcaaagcag ctgttatggc
     3361 tggaatctgg gataactcag gctcatgttc tggagcgtgg gtcctttcct tgcagtgttg
     3421 tttagatgac tgtgaagcca ttagggtgaa gccgggctgg cagaagtagg tgtctaggag
     3481 caggcaggcc ctgaaggcta taccctttcc cggctcctgg tgggctgctt tacctcctgt
     3541 gaacaggaca cccatctctg ctactatgga ctgacactgt gtgtgtgtgc gcgtgcgcac
     3601 acgcgcgcgc gtgtgtacac aagaggacaa tttctggaag tcaattgtct ccaccatatt
     3661 ggccctaggg attgactcac tagcttgact cagtgtcttt acccactgag ttccagtaag
     3721 tcagaagtac tcttttaaga aatagcaact tagggcctgg agtgacggct caggggttaa
     3781 gagcactgac tgctcttcca gaggtcctga gttcaattcc cagcaaccac atggtggctc
     3841 acaaccatct gtaacaggat ccgatttaca tataataaat aaataaatct taaaaaaaag
     3901 aaataactta attctcaagt acgtacacac acacacacac acacacacac acacacacac
     3961 acacacacac tctctctctc tctctcctac cttatcccaa gctaccctaa actcaccatg
     4021 tagactagga tgaccttgaa cttgctgaga tctgccagtc cagagccagg gtactgggat
     4081 tcaagtatcc caccaaagag gaaaataagc aaatgtacaa ggattagata gacattgccc
     4141 ataattaatt aaaattcagt gttttctgag agtggaaata ttgtcatgaa atattccctt
     4201 ttgcagcaat gctcagatct gcctctttag aatggtcttt ctttttgaat gttgctaatg
     4261 gtgtactggc tggttttgtg tatcaatttg gcacacgcta gagtcatcag agaggaagga
     4321 ccttcagttg agaaaatgcc tccatgagct ccagctgtaa gacattttca taattaggga
     4381 tcagtggggc tagcgccatt gtgggtggta ccactcctgg actggtggtc ctgggtccta
     4441 taagaaggca ggctgagcaa gccaggggaa gcaagccagt gtggggtggg ggcaccccac
     4501 tcatggtctc tgcctcagct cctgtctcca ggttcctgct ctgtctgagt tcctgtcctg
     4561 gctgcctttg gtggtgaaca tgactgctgt gtgattgcct gtctgtcact cgggctttat
     4621 ggtatcccag ggcattcaga attgggaggt gcataatgga gtgttattta agccataaat
     4681 aatgaacaga atggaattgt gtcctttgcc agaagacaga taccctggag gtcatcctgt
     4741 gaaacgcaat cagccagact cagaacagtc acctcatact ggtatttcaa aggtcttggc
     4801 tctcctgact ctatgcccat cgtgaggcag agcatagcag aggttgaagc atgtacaaag
     4861 ccttcttggc acatgggaca aagaggcaga gacaccactt tgttctgaga ttggtcttac
     4921 tgtgtagcaa agactgacct ggaattcatg cagctcagtt tggtcttgag ttcaagaccc
     4981 aactgcctta gcagttctgg gtgtgtgcta ggaagtgttc tcagataatg ttttcagagc
     5041 acgagacacc ttcatgtgta ggctatcatg agtcaactaa cctttctgtg gctggaccct
     5101 gcaggtaagg ggtggagcgc agggcagagg agagacttct ggcactctaa ggagcctgtg
     5161 gaccacctag attcttacct gctgctaaca tttccacacc acaggcaccc tctagcctat
     5221 ggcagctggg aacttatttt tgctttcaag aacccagtga taggtctgtt tctcaaatac
     5281 agctgatgtg gctgaccttg agtgaaagga gactgaaggt tttaggagac cccagtatgt
     5341 agacctgact gaacttgccc ctgaagctga cagcccattg catactcttc acatgaatga
     5401 gaaaaaggtg cctgttgtat gtggaggcct ttaacccaga tcccctgagg ccggagccca
     5461 tgtgaggcac aactacatga ccacataggg tgatgtgatg gtttgcatat ttggcccagg
     5521 gagtggcact attagaaggt gtggccttgt tggaggaagt gtgtcactgt gggggggtgg
     5581 gcttggagac cctcctccta gctgcctggg gatgctcagt ctgttcctgg cttcctttgg
     5641 ttgaagatgt agaactcagc tcctcctgca ccaggcctgc ctggatgctg ccatgctcct
     5701 gccttgataa tggactaaac ctctgatctg taagccagcc ctaattaaat gttgtccttt
     5761 ataaaactta
//
LOCUS       NM_148889               5965 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 2, mRNA.
ACCESSION   NM_148889
VERSION     NM_148889.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5965)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5965)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5965)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5965)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5965)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5965)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5965)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5965)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5965)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5965)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_148889.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078716.1, SRR26360194.1197592.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-378             JAXUCZ010000005.1  60613624-60613813   c
            379-515             JAXUCZ010000005.1  60611539-60611675   c
            516-562             JAXUCZ010000005.1  60609743-60609789   c
            563-829             JAXUCZ010000005.1  60609265-60609531   c
            830-889             JAXUCZ010000005.1  60607510-60607569   c
            890-1116            JAXUCZ010000005.1  60605329-60605555   c
            1117-1220           JAXUCZ010000005.1  60599244-60599347   c
            1221-5965           JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5965
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5965
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            189..378
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    335..337
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            379..515
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1375
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform a is encoded by transcript variant 2;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform a"
                     /protein_id="NP_683687.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MRVCWLVRQDCWHQRIKLPHLEAVVIGRSPETKITDKKCSRQQV
                     QLKAECNKRYVNVKQMGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEV
                     AESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKI
                     SMKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVG
                     EKVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLE
                     SQAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    386..670
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interactions with ADPRT/PARP1 and NCL.
                     /evidence=ECO:0000250"
     misc_feature    389..688
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    389..688
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    order(464..469,503..508,512..514,572..577)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    order(464..469,503..508,512..514,572..577)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    701..832
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    716..730
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    743..745
                     /gene="Aptx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQC5; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); phosphorylation site"
     misc_feature    836..1141
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    836..1141
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    866..868
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    923..937
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    1097..1099
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1109..1114
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    order(1118..1120,1124..1126,1130..1138)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(1118..1120,1124..1126,1130..1138)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    1118..1132
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Histidine triad motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00464"
     misc_feature    1124..1126
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    1124..1126
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    1130..1132
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1175..1177
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1193..1366
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    1193..1366
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            516..562
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            563..829
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            830..889
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1116
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1220
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..5965
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagat ggtaacaata ttctcatctt taagaatatg atttctttga tcttcatttc
      241 tgaatacagc aatcgtgcag aaggcctgca tgctgcttgg gcaggaggca agatatcccc
      301 caaggtacca gaagctcgaa cattgataag gctctagagc agtggctctc gaccccttcc
      361 ccaggggtca catatcagag ccaagatgcg ggtgtgctgg ttggtgagac aggactgctg
      421 gcaccagcga atcaaacttc cccatttaga agctgttgtg attggtcgaa gcccggagac
      481 caagatcaca gataagaaat gttcccgaca gcaagtacag ttgaaagcgg agtgtaacaa
      541 gagatatgtc aacgttaagc agatgggggt caatcccacc agcattgacg aagtcgtcat
      601 tgggaaggac cgggagatga agctgctgcc tggtcaggtt ctccacatgg tgaatgaact
      661 ttatccatac atggtggagt ttgaggaggt ggcagagagc cctaacgtaa cacagaggaa
      721 gagaaagagg ccagactgtg atagtcagga gatggaagct gaggctgggg ccagccccag
      781 ccagtgctct gtgtccccta agacgggcaa gcatggagcc gccaaggagg aatcactggg
      841 ccactggagt caaggcttga agatatctat gaaagacccc aaaatgcagg tttataagga
      901 tgatcaggtg gtggtgatta aggataaata ccccaaggcc cggcaccact ggctggtctt
      961 accatgggcc tccatttcca gtctgaaggt tgtgaccagt gaacacctcg aacttctcaa
     1021 acacatgcac gcagtagggg aaaaggtgat agcagatttt actggatcca gcaaactgcg
     1081 cttccgactg ggttaccatg ccattcccag catgagccat gtacatcttc atgtgatcag
     1141 ccaggatttt gattctcctt gccttaaaaa caaaaagcat tggaattctt tcaatacaga
     1201 atattttctg gagtcacaag ctgtgatcaa gatggttcag gaagctggca gagtgactgt
     1261 taaagatggg acttgcgaac tcttgaagct gcctctccgt tgccatgagt gtcagcagct
     1321 gctgccttcc atcccacagc tgaaggagca cctcaggaag cactggggcg ggtgacactc
     1381 gccttggtga ccgagtgcag tgctagcatc attctgcatt gcctgcgctc cgttcagtcc
     1441 tgaactaaag catgcagctc ttcaaaacaa agcttattat tcttgagtga ccacacaggg
     1501 tgactctggg tcaggaactg ggaatatggg tttgtatggt atattttctg gtaatggagg
     1561 atgagacatg cctgatcact cttcccaaga ccatgtcagg cctgactaat aagagggcag
     1621 agccagcttg aggttcaaat acaagatgta gaagcagagg actggtaatg tatttgttcc
     1681 tacccttgcc cctggatcat gttctatctt tttatcaaga tagctgaggt tctgaggggg
     1741 cctggttcct gctctatgat attcctcttc cctccatgag gaggctttca atctactgta
     1801 ccaggctgag tgcctgggtg aacatatgtg gcagtcatct gcacagagag atactttgtg
     1861 tatgactgtg ccagggaact ggaagtggta atattgggca cagtatgtta acagtacagc
     1921 ctgtgtcgag ggcaaactgg ggtaatgtga actgccagta aacagtacat cctctgctga
     1981 gggcagcctg gggcagtgtg aactgccagt aaacagtaca gcctgtgctg agggcagcat
     2041 ggaacagtgt gaactgttag tgaacagtag tctgttctga gggcagcctt gtacagtgat
     2101 gtcagttaac agtgcagtct gttgagggca tcctgggatg gtgtgaactg tcagttaaca
     2161 gtgcagtctg ttgagggcat cctgggatgg tgtgaactgt cagttaacag tgcagtctgt
     2221 tgagggcatc ctgggatggt gtgaactgtc agttaacagt gcagtctgtt gagggcatcc
     2281 tgggatggtg tgaactgtca gttaacagtg cagtctgttg agggcatcct gggatggtgt
     2341 gaactgtcag ttaacagtgc agtctgtgtt gagggcagcc tgggcagtgt gtattgttag
     2401 cttcaggcag attttacgga ggcttcagcc actgctcttg agaattacag aacatttaac
     2461 taaacttcgg ataatgtatc ttagaaaaac agatgttgca aaatagttca tttactttcc
     2521 acctgataca atatagttta gcacatcagt attaaaatga gtatttgctg taaactacta
     2581 ggagtgtctg tatcagacag cgtaagaatg tcaggtataa tgagaaacat ttggggaatg
     2641 aggtgaccat gcttacattc ttccttctgc ccaaaataga tttttttaag actggggtga
     2701 gtgcatgctg cccttcctag gacctgagtt ttgttcccgg catccatatt aggtggctca
     2761 cagctgcctg tagctccagg gatcctgcac ctgcttcttg acctctgtgg gcactgcatt
     2821 caagtacaca aacctgaata cagacacaca ttcacacata attaaatctg taaaaatcag
     2881 atctcgggct ggagagatgg ctcagtggtt aagagctcct ccagaggtcc tgagttcaat
     2941 tcccagcaac cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg
     3001 tatgcatgga gacagccaca gtgcacttat acataaataa atacataaat aaaaaaaata
     3061 gatctcttag aggaaaaatg tcaataatga ctggcaggaa gcaggtattg aggtattgag
     3121 gtttattcat tccctagccc tcctctccga aatgggcttt tatcaccatg gggaagaaga
     3181 ctgtctggac tctggattac ttgacagaca tgtcattgta caattagttg aagctttcct
     3241 tcagagtcag agggagggat gttgggagac tgcaaagtag aagaaagcca gccacattta
     3301 aagctaggca cagtggcaaa ttctcttgca atcccaaatt taggaggtgg tagatccagg
     3361 agggccaggc attccaggtt atccttgtct atatggtgaa cttgaggtct ggactacatg
     3421 agaccctatg tcacagaagc aaataaataa aagatttaaa aaggggaaat aaaattctat
     3481 ctaaggtacc aaagcatatt atttggccca tcatggccag gcaagaccag ttgttatcaa
     3541 agcagctgtt atggctggaa tctgggataa ctcaggctca tgttctggag cgtgggtcct
     3601 ttccttgcag tgttgtttag atgactgtga agccattagg gtgaagccgg gctggcagaa
     3661 gtaggtgtct aggagcaggc aggccctgaa ggctataccc tttcccggct cctggtgggc
     3721 tgctttacct cctgtgaaca ggacacccat ctctgctact atggactgac actgtgtgtg
     3781 tgtgcgcgtg cgcacacgcg cgcgcgtgtg tacacaagag gacaatttct ggaagtcaat
     3841 tgtctccacc atattggccc tagggattga ctcactagct tgactcagtg tctttaccca
     3901 ctgagttcca gtaagtcaga agtactcttt taagaaatag caacttaggg cctggagtga
     3961 cggctcaggg gttaagagca ctgactgctc ttccagaggt cctgagttca attcccagca
     4021 accacatggt ggctcacaac catctgtaac aggatccgat ttacatataa taaataaata
     4081 aatcttaaaa aaaagaaata acttaattct caagtacgta cacacacaca cacacacaca
     4141 cacacacaca cacacacaca cacactctct ctctctctct cctaccttat cccaagctac
     4201 cctaaactca ccatgtagac taggatgacc ttgaacttgc tgagatctgc cagtccagag
     4261 ccagggtact gggattcaag tatcccacca aagaggaaaa taagcaaatg tacaaggatt
     4321 agatagacat tgcccataat taattaaaat tcagtgtttt ctgagagtgg aaatattgtc
     4381 atgaaatatt cccttttgca gcaatgctca gatctgcctc tttagaatgg tctttctttt
     4441 tgaatgttgc taatggtgta ctggctggtt ttgtgtatca atttggcaca cgctagagtc
     4501 atcagagagg aaggaccttc agttgagaaa atgcctccat gagctccagc tgtaagacat
     4561 tttcataatt agggatcagt ggggctagcg ccattgtggg tggtaccact cctggactgg
     4621 tggtcctggg tcctataaga aggcaggctg agcaagccag gggaagcaag ccagtgtggg
     4681 gtgggggcac cccactcatg gtctctgcct cagctcctgt ctccaggttc ctgctctgtc
     4741 tgagttcctg tcctggctgc ctttggtggt gaacatgact gctgtgtgat tgcctgtctg
     4801 tcactcgggc tttatggtat cccagggcat tcagaattgg gaggtgcata atggagtgtt
     4861 atttaagcca taaataatga acagaatgga attgtgtcct ttgccagaag acagataccc
     4921 tggaggtcat cctgtgaaac gcaatcagcc agactcagaa cagtcacctc atactggtat
     4981 ttcaaaggtc ttggctctcc tgactctatg cccatcgtga ggcagagcat agcagaggtt
     5041 gaagcatgta caaagccttc ttggcacatg ggacaaagag gcagagacac cactttgttc
     5101 tgagattggt cttactgtgt agcaaagact gacctggaat tcatgcagct cagtttggtc
     5161 ttgagttcaa gacccaactg ccttagcagt tctgggtgtg tgctaggaag tgttctcaga
     5221 taatgttttc agagcacgag acaccttcat gtgtaggcta tcatgagtca actaaccttt
     5281 ctgtggctgg accctgcagg taaggggtgg agcgcagggc agaggagaga cttctggcac
     5341 tctaaggagc ctgtggacca cctagattct tacctgctgc taacatttcc acaccacagg
     5401 caccctctag cctatggcag ctgggaactt atttttgctt tcaagaaccc agtgataggt
     5461 ctgtttctca aatacagctg atgtggctga ccttgagtga aaggagactg aaggttttag
     5521 gagaccccag tatgtagacc tgactgaact tgcccctgaa gctgacagcc cattgcatac
     5581 tcttcacatg aatgagaaaa aggtgcctgt tgtatgtgga ggcctttaac ccagatcccc
     5641 tgaggccgga gcccatgtga ggcacaacta catgaccaca tagggtgatg tgatggtttg
     5701 catatttggc ccagggagtg gcactattag aaggtgtggc cttgttggag gaagtgtgtc
     5761 actgtggggg ggtgggcttg gagaccctcc tcctagctgc ctggggatgc tcagtctgtt
     5821 cctggcttcc tttggttgaa gatgtagaac tcagctcctc ctgcaccagg cctgcctgga
     5881 tgctgccatg ctcctgcctt gataatggac taaacctctg atctgtaagc cagccctaat
     5941 taaatgttgt cctttataaa actta
//
LOCUS       NM_001436631            4064 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus DDHD domain containing 2 (Ddhd2), transcript
            variant 5, mRNA.
ACCESSION   NM_001436631 XM_063275720
VERSION     NM_001436631.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063275720.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.47312.1,
                                           SRR26360176.801048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000016.1  73022193-73022329
            138-363             JAXUCZ010000016.1  73023386-73023611
            364-554             JAXUCZ010000016.1  73024257-73024447
            555-644             JAXUCZ010000016.1  73025595-73025684
            645-765             JAXUCZ010000016.1  73026637-73026757
            766-855             JAXUCZ010000016.1  73027465-73027554
            856-991             JAXUCZ010000016.1  73029229-73029364
            992-1200            JAXUCZ010000016.1  73033702-73033910
            1201-1268           JAXUCZ010000016.1  73034155-73034222
            1269-1391           JAXUCZ010000016.1  73035946-73036068
            1392-1487           JAXUCZ010000016.1  73036977-73037072
            1488-1520           JAXUCZ010000016.1  73038456-73038488
            1521-1676           JAXUCZ010000016.1  73038642-73038797
            1677-1779           JAXUCZ010000016.1  73039438-73039540
            1780-1950           JAXUCZ010000016.1  73039664-73039834
            1951-2110           JAXUCZ010000016.1  73041377-73041536
            2111-2217           JAXUCZ010000016.1  73049473-73049579
            2218-4064           JAXUCZ010000016.1  73049900-73051746
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4064
                     /gene="Ddhd2"
                     /note="DDHD domain containing 2"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
     exon            1..137
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..363
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2192
                     /gene="Ddhd2"
                     /note="isoform 2 is encoded by transcript variant 5;
                     phospholipase DDHD2"
                     /codon_start=1
                     /product="phospholipase DDHD2 isoform 2"
                     /protein_id="NP_001423560.1"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
                     /translation="MSSGESYQEQLSQSDPSPSPNSSSSFELLDMDVGSSYEPVSPHW
                     FYCKVIDSKELWIPFNSEDSQQLEEAHGSGKDCNERVVPTDGGRYDVHLGERMRYAVY
                     WDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKLESPNREI
                     IVLHNPKLMVHYQPITGSDEWGSTSTEQGRPRSVKRGVESIPVDIHCGEPLQIDHLVF
                     VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPL
                     HSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLF
                     LQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSIGDIDSEKGSLSTAEDLGDVSTLEE
                     ELKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSATKSSVGI
                     NRPTMSASEVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPTCKGFFNI
                     YHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSL
                     RMAWKSFTRAPYPALQASEMAEDTEAESEPSSEKPSDANTEEPPVEVKEEAPINVGML
                     NGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
                     "
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1542..2153
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    1542..2153
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     exon            364..554
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..644
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..765
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..855
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..991
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1200
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1268
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1391
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1487
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1520
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1676
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1779
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1950
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2110
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2217
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..4064
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctcagg ccctgaaccg ggtgagcgga ctccgcaggg ctcactgctc gcggctggat
       61 cgctgaggag cccgtggtgc gggattgggg cgcggccaca ggctccgccc gtctgcccgc
      121 cccgcccggc ttgggagagc gaaatgtcat caggggaatc gtaccaggag cagctgtcac
      181 agtcagatcc atccccctcc ccaaactcca gtagttcctt cgagctgcta gacatggatg
      241 ttggcagttc ctacgaaccc gtttctccac attggtttta ttgtaaggta atagactcta
      301 aggaactctg gattcctttc aactctgaag attcacagca gctggaagaa gcacatggct
      361 ctggaaagga ttgtaatgag agagttgtcc ccactgatgg gggcagatat gatgtccatc
      421 tcggggagag gatgcggtat gccgtgtact gggatgaact accatcagaa gtgagacggt
      481 gcacgtggtt ttacaaggga gacaaagaca ataagtacgt cccctactcc gagagcttca
      541 gccaagtttt ggaggataca tatatgcttg cggtaactct ggatgaatgg aaaaaaaaac
      601 tagagtctcc aaacagagaa attattgtat tacacaaccc aaagctcatg gtgcattacc
      661 agccaatcac agggtctgat gaatggggtt caacatccac tgagcaaggt cggccaagat
      721 cagtaaaaag aggcgttgag agcatccctg ttgatattca ctgtggggaa cctttacaaa
      781 tagatcactt agtgtttgta gtccatggga ttggaccagc ttgtgatctc cgttttcgaa
      841 gcattgttca atgtgttaat gattttcgaa gtgtttcctt gaacctgcta caaacacatt
      901 ttaagaaagc ccaagaaaac cagcagattg gaagggtaga gttccttccg gtcaactggc
      961 acagcccttt gcattctact ggagtagata tagatctgca gcggataacc ctacccagca
     1021 tcaatcgcct tagacacttc actaacgata caattctgga tgtcttcttc tacaatagcc
     1081 ccacctactg tcagactatt gtggacacag tagcttctga aatgaaccga atatatacac
     1141 tttttctgca gaggaaccct gatttcaaag ggggtgtatc cattgctggt catagtttag
     1201 gttcgcttat attgtttgat atcctaacaa atcagaaaga ttctattggg gatattgaca
     1261 gtgaaaaggg ttcattgagt actgctgagg atctaggaga tgtatcaaca ttagaagaag
     1321 aactgaagaa gcttcagctc tctgagtttg tcactgtctt tgagaaggag aaagttgaca
     1381 gagaagctct ggctttatgt acagacagag atcttcagga aatggggatt cccttaggac
     1441 ccagaaagaa gatactgaac cacttcagtg ccacaaagag ttcagtgggt attaatagac
     1501 caaccatgtc agcttctgag gtgtctgtaa aatacccccg gcttaactac aaaccagaaa
     1561 tattctttgc ctttggatct cccattggaa tgtttcttac tgtccgagga ttaagaagaa
     1621 ttgatccaaa ttataaattt cccacatgca aaggtttctt caatatttac catccttttg
     1681 atcctgtggc atataggatt gaaccaatgg tggtcccagg agtagaattt gagccaatgc
     1741 tgattccaca tcataaaggc aggaagcgga tgcacttaga actgagagag ggcttgacca
     1801 ggatgagtat ggacctgaag aacaacttgc tgggttcact gaggatggcc tggaagtctt
     1861 tcaccagagc tccataccct gccttacaag cttcagaaat ggcagaagac actgaggcag
     1921 aatccgaacc aagttcagaa aagcccagtg acgccaacac agaagagcct cctgtggagg
     1981 tcaaagagga ggctcccatc aatgtgggaa tgctgaatgg aggccagcgc attgactatg
     2041 tgttacagga gaagcccatt gagagtttta atgaatattt atttgctcta caaagccatc
     2101 tatgctactg ggaatctgaa gatacagtac tgcttgtcct caaagagatc taccaaaccc
     2161 aggggatctt ccttgatcag cctttacagt aaaatgaccc atctgtggct gcttaatatg
     2221 gacattgagg gagcctttcc tgaaaacccc ctcacttgtt gctgcagctt tcttctcagc
     2281 taccgtgtgt cctgcatgtt gcctgcctta ctccacggga tctttcaaga taaccctctt
     2341 tggaaactag gtgaaagcag agggaagact gcctcatatg aactctcgcc atttttgtag
     2401 ctagggactt ccatatttaa tgctttagca gcagcccctc cttggttatt acatggaaat
     2461 ggatagtctg ttaagggggc ttagagagct ttatgtcctc tccttagaaa gtgggcccgt
     2521 tggggagctt atgaagatgg agaggactta ggggtccagt cgcactggag ggctaagcat
     2581 gtgtggatgt gggatagctg ctaggttttg agccagcatt tatttctttg ctgtgtgtga
     2641 aaaccagagg ctgccctgag cactcacatg gcactgtagg gaccactggg gctgtttgtg
     2701 gttgttatag ttgcctcagc gtctgtaacc ccagaggctg tatgggctgt gtgcctgccc
     2761 ttctacacca tactccaaac cagggtgaag tgcagggagt gaggtggtaa tacttacttg
     2821 aaggtcaccc tgaagttaca tggtccttct cagctgttca tgtagaaaat gtggtttttt
     2881 agtagcacgg acttgtcacc tgcttcttca cttgagaaaa ggaagtattg tgacataaac
     2941 gtcactgctt tctgaggtat catcaaaatg tttacttata gttggcagtc agtgtagttg
     3001 agcatgcagg ttaggcaagg gggaagacca cattctgaaa gaaaatcctg tctacagggt
     3061 ctgaggagca gctgtataca ctgtgcagtg gcagctgaat ctgcagaatt caaagcacgt
     3121 ttatcctgag gaagaatgac tgtatactgt cttccccttc ctcagcatgt gctgtcgtcc
     3181 gtcctcttca tgattgtcct ttattctcct tagttagctc ctccgatttc cacaggtctc
     3241 tttataggtg agctgtggtt tgatttttga cctttttttg taaactgatc atggtatcca
     3301 gaggcactgc acataacacg ccctgaagcc cctcagatgg tggtgccctt gacacaccgg
     3361 gagagggagg cgagcactgt gccctggagg tcagaggcac aggacagtca ggcctggcct
     3421 tcctttctgc ttatgggtaa tactggataa gcaagctact gaggagttcc aggtatatgg
     3481 aatattttat tttttctaca gtatgtcttg agtaagaata tctgagaatg aagtagtatt
     3541 cattaaatac tagagtaatt ttgtcaattg ttgtcttgag atttgtttac tcttgttagc
     3601 agtcattact atgttaagag taaaccaaag cacaactgag tgtgttcttg tgaccaaaga
     3661 tgggcagctt ggccctggag agctagataa accactgcac taagaaatgc tgcttcccgg
     3721 cagtccagta cagtaactca aagagcttgc acctcaccat ccactcgtgg cgttatcacg
     3781 ctcagtatta cacaagtgag tagggcaagg ggcctgggta cgggtgtgca ttgcgtcatt
     3841 tgttaccatg tacagtttct tgaccaaggc tgtttttaaa ctccagtgta acagcatttt
     3901 gtacgtaatt ctggctacac aattcgtgag agactgtttg caagggatga acagcactga
     3961 ttaccttcct gatattttgc acttttgaaa tgttttgttt tatatgtgat tatatttaag
     4021 actttagtaa atgctgaaat aaaactattg accatttacc taca
//
LOCUS       NM_001436647            3876 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus chondroitin sulfate
            N-acetylgalactosaminyltransferase 1 (Csgalnact1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436647 XM_039094495
VERSION     NM_001436647.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3876)
  AUTHORS   Sato,T., Kudo,T., Ikehara,Y., Ogawa,H., Hirano,T., Kiyohara,K.,
            Hagiwara,K., Togayachi,A., Ema,M., Takahashi,S., Kimata,K.,
            Watanabe,H. and Narimatsu,H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is
            necessary for normal endochondral ossification and aggrecan
            metabolism
  JOURNAL   J Biol Chem 286 (7), 5803-5812 (2011)
   PUBMED   21148564
REFERENCE   2  (bases 1 to 3876)
  AUTHORS   Watanabe,Y., Takeuchi,K., Higa Onaga,S., Sato,M., Tsujita,M.,
            Abe,M., Natsume,R., Li,M., Furuichi,T., Saeki,M., Izumikawa,T.,
            Hasegawa,A., Yokoyama,M., Ikegawa,S., Sakimura,K., Amizuka,N.,
            Kitagawa,H. and Igarashi,M.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required
            for normal cartilage development
  JOURNAL   Biochem J 432 (1), 47-55 (2010)
   PUBMED   20812917
REFERENCE   3  (bases 1 to 3876)
  AUTHORS   Gotoh,M., Sato,T., Akashima,T., Iwasaki,H., Kameyama,A.,
            Mochizuki,H., Yada,T., Inaba,N., Zhang,Y., Kikuchi,N., Kwon,Y.D.,
            Togayachi,A., Kudo,T., Nishihara,S., Watanabe,H., Kimata,K. and
            Narimatsu,H.
  TITLE     Enzymatic synthesis of chondroitin with a novel chondroitin sulfate
            N-acetylgalactosaminyltransferase that transfers
            N-acetylgalactosamine to glucuronic acid in initiation and
            elongation of chondroitin sulfate synthesis
  JOURNAL   J Biol Chem 277 (41), 38189-38196 (2002)
   PUBMED   12163485
REFERENCE   4  (bases 1 to 3876)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039094495.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.47978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000016.1  25762253-25762375
            124-272             JAXUCZ010000016.1  25915023-25915171
            273-1200            JAXUCZ010000016.1  26002429-26003356
            1201-1417           JAXUCZ010000016.1  26052126-26052342
            1418-1519           JAXUCZ010000016.1  26065782-26065883
            1520-1698           JAXUCZ010000016.1  26079602-26079780
            1699-1793           JAXUCZ010000016.1  26080645-26080739
            1794-1875           JAXUCZ010000016.1  26091895-26091976
            1876-3876           JAXUCZ010000016.1  26095306-26097306
FEATURES             Location/Qualifiers
     source          1..3876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3876
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
     exon            1..123
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            124..272
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1200
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    564..566
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="upstream in-frame stop codon"
     CDS             573..2165
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /EC_number="2.4.1.174"
                     /note="chondroitin beta1,4
                     N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001423576.1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
                     /translation="MVRRGLVGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLP
                     RANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGQDQASDAT
                     SLRSGWDPEPKAQADILAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETG
                     LTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRPYTAADFIEGIYRTERDK
                     GTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKKEKLNMANTLINVIVPLARRVDKFRH
                     FMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSR
                     GKGLDVGARFWKGSNVVLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGI
                     IYGHHDAVPALEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVH
                     LYRKYLHSNLIVIRTPVRGLFHLWHEKHCMDELTPEQYRMCMQSKAMNEASHGQLGML
                     VFRHEIEAHLRKQKLKASSKKT"
     misc_feature    774..2087
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     misc_feature    774..2087
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     exon            1201..1417
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1519
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1698
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1793
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1875
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..3876
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgttgga actggaggtg gagccgagcc cagggccgcc tcgcaggagg gaaagttcgg
       61 cggcgccggg cgggagcagc gtagccaagg gagccggctc cgctgtctgc agggttgctt
      121 gggtggtggc gctgagctga acacggtgct agcagaaggg ggcggtactt tccctctgga
      181 ccctgacttg gaagccaagt gcgactcgag cgcagtcacc gccagaagca gatgtgtgag
      241 cggagcagct gtgcgcctct ctttctgccg aggatccccc tcatcttcag cacatcagga
      301 agactatgat ggaaacaaaa gaaagaactt ggaggttcca cttaactgat tgtttctgcc
      361 tagaggatct tctcttggaa gcaggagagc cttctcatgt aatggctgac ttccaaagac
      421 aggctatgtt ctagaaggaa atggatggaa tcagttcagg ggacttcagc cgcactgtgg
      481 tctaaccaga aaagcccgtg ttgggggccc tcctggtgcc ctgggatgtt gcatactctg
      541 gacctggatg catggcccgc acctgagtga ggatggtccg acgcgggctg gtggggtgga
      601 tttcccgggt agtgattctg ctggtgctgc tctgttgtgc catctctgtt ctctacatgt
      661 tagcctgcac cccaaaaggc gaccaagagc agctgggact gccacgggcc aacggcccca
      721 caggcaaaga tggctaccaa gcggtgctac aggagcgtga ggaacagcat cgcaactatg
      781 tgaatagtct taagcgacag atcgcgcagc tcaaggatga actgcaggca cgcagtgagc
      841 agctccgcag tgggcaggac caggccagcg atgccaccag cctgcggtca ggctgggacc
      901 ctgaacccaa agcccaggct gatatactgg ccttcctgcg tgggcaggtg gacaaggctg
      961 aggtccacgc cggtgtcaag ctggccaccg aatatgctgc tgtgcctttt gatagcttca
     1021 ctctgcagaa agtataccag ctggagactg gtctgacccg ccaccctgag gagaaaccag
     1081 tgaggaagga caagcgagat gagctagtgg aagctatcga atcagccctg gagagtctaa
     1141 acagccctgt ggaaagcagc ccacaccagc gcccttacac ggctgcagac ttcatagaag
     1201 ggatctaccg aacagaaagg gataaaggca ctttgtatga gctgaccttc aaaggggacc
     1261 ataagcatga attccaacga cttgtcctat ttcgaccttt tggccccatc atgaaagtga
     1321 agaaggaaaa gctcaacatg gccaacacac ttatcaacgt tatcgtgccc ctagcgagga
     1381 gggtggacaa gttccggcac ttcatgcaga acttcaggga gatgtgcatc caacaagatg
     1441 ggagagttca tcttaccgtt gtttattttg ggaaagaaga aatgaatgaa gtcaaaggaa
     1501 tacttgaaaa cacttccaag gctgccaatt ttagaaactt caccttcatc cagctgaatg
     1561 gagagttctc ccggggaaag ggactggatg ttggagcccg cttctggaag ggaagtaatg
     1621 tcgtgctctt tttctgtgat gtggacatct acttcacctc tgagttcctc aacacatgta
     1681 ggctgaacac acagccaggg aagaaggtat tttatccggt tcttttcagt cagtataacc
     1741 ctggcataat ctacggccat catgatgctg tccctgccct agaacagcag ctggtcataa
     1801 agaaggaaac aggattttgg agggactttg gattcggaat gacttgtcag taccggtcag
     1861 acttcatcaa cataggtgga tttgacctgg acatcaaagg ctggggcggt gaagatgtgc
     1921 acctgtaccg gaaatatctc catagcaacc tcatagtgat acgcacgcct gtacggggac
     1981 ttttccacct ttggcatgag aagcactgta tggatgaact gacccctgag cagtacagga
     2041 tgtgcatgca atcaaaggct atgaatgaag catcccacgg gcagctggga atgcttgtct
     2101 tccggcatga aatagaggct caccttcgca aacagaagct caaagccagc agtaaaaaga
     2161 catgacctcc caggtaaaga ttagccaaga cgtttaaatt ttgtgccttt ggcagttact
     2221 gaagaagtag atgcaacaag gtatagactt ccacaaaggg caacagagaa tctgactgat
     2281 gagtgacaga tgaatgaaga gtctcgggtt tctgttggct ctgtgtatgc tggtgactct
     2341 gactgtgttt acagccaaat gagctctctg gtccctgctc cctgaaatag tcacaaccgg
     2401 tttcagaaaa ccagaaggag ctgcaagccc actgacttct cttctttgga ttggttacat
     2461 cagagggctt tggtactact aggactacca aaggctcaga tggagctctc ggacggagca
     2521 gaggacctgt gtgaaaagtg gagctctgac attagtgtcc tccaccagac cgtgagcaaa
     2581 atcaaaggga cctggaaaca aaccatccaa actgtcattt ccctagtatt aactgaaaaa
     2641 caaacaaaca aacaaacaaa aaccctaaaa aacaaaaaaa agacaaaaac aaaaacaaaa
     2701 aacaaagcca acaacaacta caacaaaaac ccctctcttt cccattattg tttagtcatc
     2761 tctgttctaa aaatgcactt tttttgcttc tgagcattat gcttatttaa ttacccattt
     2821 ccaagcctta gtaggagtac attgtagtac acacattttt atgatttttt taaagatttg
     2881 tttttatgtt tttgctgatt tgtttacttg agacagtctt gacacagagc ccgagataac
     2941 ttgaaatcct gatcctcctg tctccgaagc ctgagtgctg agattacagg tagctagaag
     3001 atacgtgcag aggcgtggag tgaggagctc cagttgcagg catgtggagc tgatccaagg
     3061 acttgccagt ctccgaccac aagaaggcta catgtggggc tgcagagaga aaggtatcta
     3121 caaactaaga ctgtcggaag aggagcaatc aaacactgga aaaagaaaaa gatacttttc
     3181 acaaagaaag gacactaaga agaccttcgt gtatttacta gagaatataa tttctcttct
     3241 ggagaaatgg gaccactttc ttacctgttt gaataaacca aagttatgaa ccaaatgatc
     3301 acttttcaaa acagggtgct cttcttggtc tctggtttgc ataaagaaga aactgcagga
     3361 aatatatata tgtatatata tatatatata tatatatata tatatatata tatatatttt
     3421 gaaagacaaa tccattaacc cagtgaggtg gaagattctg ctccatttcc attcactcct
     3481 ggctaggtgg aagcaactta tttttaaaat aagcaatgtt acctgattgc caagacgctt
     3541 ctgaagcatt ttcttacaac tccaaatttg tttttttaaa aaaaataaat ctgattaaca
     3601 ttgagtggtt tctacatcca tgtgcaaatt atttatttat tagccagcac cagatgcatg
     3661 agctaattac ctctcctgtc tctgtgcctt ctgtttgccc acagtgaact cattgtttaa
     3721 atgcttcaag aacactcaag ctgtgtgttt aaaaaaaaaa aaaggattgt attgatttgt
     3781 actggtagtt tataaaattt aattaaaaca caagacatga atgaaaggtg gcattgcaca
     3841 gctaataaaa tttgtgaatt tgatttcttt ccataa
//
LOCUS       NM_001436616            2430 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 6, mRNA.
ACCESSION   NM_001436616
VERSION     NM_001436616.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2430)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2430)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2430)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.457773.1,
                                           SRR26643293.75526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000016.1  73925752-73925871
            121-200             JAXUCZ010000016.1  73926790-73926869
            201-256             JAXUCZ010000016.1  73927485-73927540
            257-333             JAXUCZ010000016.1  73930126-73930202
            334-511             JAXUCZ010000016.1  73931687-73931864
            512-577             JAXUCZ010000016.1  73932826-73932891
            578-649             JAXUCZ010000016.1  73934031-73934102
            650-807             JAXUCZ010000016.1  73934279-73934436
            808-889             JAXUCZ010000016.1  73935273-73935354
            890-1026            JAXUCZ010000016.1  73939574-73939710
            1027-1216           JAXUCZ010000016.1  73941664-73941853
            1217-1312           JAXUCZ010000016.1  73946164-73946259
            1313-1508           JAXUCZ010000016.1  73947426-73947621
            1509-1599           JAXUCZ010000016.1  73957828-73957918
            1600-1816           JAXUCZ010000016.1  73958685-73958901
            1817-1903           JAXUCZ010000016.1  73973622-73973708
            1904-2018           JAXUCZ010000016.1  73974416-73974530
            2019-2181           JAXUCZ010000016.1  73981312-73981474
            2182-2235           JAXUCZ010000016.1  73983410-73983463
            2236-2430           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2430
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            121..200
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            201..256
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    248..250
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="upstream in-frame stop codon"
     exon            257..333
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            334..511
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2248
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 5 is encoded by transcript variant 6; a
                     disintegrin and metalloprotease domain (ADAM) 5; tMDC II;
                     a disintegrin and metalloprotease domain 5; disintegrin
                     and metalloproteinase domain-containing protein 5;
                     transmembrane metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein II; a disintegrin and
                     metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 5"
                     /protein_id="NP_001423545.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTYS
                     WSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGFI
                     NTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFVE
                     HPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCHC
                     TGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRIC
                     GNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLCR
                     KSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKYV
                     RGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQI
                     RDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLVD
                     FQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSAK
                     QQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVSN
                     TKMTTNEGSTLH"
     misc_feature    539..1120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    539..1120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1181..1405
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1181..1405
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1415..1846
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1415..1846
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            512..577
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            578..649
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            650..807
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            808..889
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1026
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1216
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1312
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1508
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1599
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1816
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1903
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2018
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2181
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2235
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2430
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgccctc cccacctgcc tggccagatg ctcctcagct aagctccagg accaccaagg
       61 gagccatgtt cctccttctt ttgctggttg tgcatcttaa tgggctgcag gcaggccaac
      121 atcctcagaa aaccatcctg caaacaactg ttcctgaaaa gatctcatca ccagatgtgg
      181 aaacagatcc agaaaaccat atggcttatc ttattacaat aaatgaaaac ccccatttca
      241 tccatcttaa aaagcaaaaa attgcaatta caacggatac gttgcaggtt ttccaaattc
      301 tatcgtgtcg ctcaccgttt gctcaggact caggggaatg atacaatttg aaaatgtctc
      361 ctatggaatc gaacctgtgg aaaccctgtc aggatttata cacgtgatct atgagaacac
      421 aaatcagcaa gctaagattc ctgacttagg agagaatcag acgtacagtt ggtctgatga
      481 attagattat caattccgaa gcaacatgaa gaaatccgga tttgccgtgt tacggccacg
      541 gtacattaag acggatatcg tcgtggataa aaagctgttt gattacatgg gctccgacac
      601 tagggtcgtg ctacagaaag tcattcagat catcggtttc attaacacta tgttctccaa
      661 gttgaaactg acggttttaa taaattccgt tgaaatctgg tcgaaggaaa acagaattga
      721 tttcccagag gcacctgaaa acttactggt ccagttttta cattggaaac ataagtatag
      781 accgcagcac atttcatact tactggcatt tgtggagcat cctgcttcca cgggagccct
      841 ctatccgggg aatctgtgca aaccgatcta tggtgctgcc attgccctgt accctaaagg
      901 tttgtcacta gagtcctaca gcgtcatcgt cctacaacta ctgagcatcg gtataggctt
      961 aacctatgac aacgctgaca gctgccactg tacaggagac gtctgcctga tgacgcccaa
     1021 ggcaatatat tctgggggtg tgaaggactt cagtacttgt agcttggatg acttcaaata
     1081 cctgtcaaca caagaccttg aatgtctcca ggacttgcct atggaaagac aaaagaagaa
     1141 gccttccagg ccaaggagaa tctgtggcaa cgggatattg gaaatgaacg agcagtgtga
     1201 ctgtggcact ttgaagaatt gtacacacaa aaaatgctgt gaccccatgt cgtgccgact
     1261 gaagtccaaa gccgtgtgtg gctccgggga gtgctgtggt caggactgca aggtaaaacc
     1321 ggttaatgta ctctgtagaa agtcgaagaa tgaatgtgac tttgaggagt actgtaacgg
     1381 aaatgacgct tactgtgtcc ctgacacgtt cgcacgcaac gggcagtact gcgactcagg
     1441 gcaagccttc tgctacagtg gtctttgtat gacgagtaat aatcaatgca tgaacttgct
     1501 cgggaaatat gtgagaggag cttccttcgc atgctatgaa gagttcaatt ccagaaacga
     1561 tagatttggc aactgtatta gaaagttttg tagtttcgaa aattctctct gtgggaagtt
     1621 ggtctgtacc tggccattca agaggctgct catgaaagac aatatgtctg cggcttatgg
     1681 acaaatccga gacgatttat gcatctctct gtataaagga gggaggccac ttaagacaac
     1741 attgtcaaca tattccgata tgtcagaaag agacgaaaca tttgtaaaag acggcacaat
     1801 ctgtggtcct gatatgtttt gtttggaaac acagtgcaaa gaaacgagat ttttggtgga
     1861 ttttcaacag tgcaatactt cccgagattg caatgaccat ggggtttgca acaactttaa
     1921 tcattgtcat tgtgataaag gatataaccc tccctattgt gagtcagtaa aaggacagtt
     1981 tggaagcatt gatgacggcc acaaatatta cattgacgaa gggaaaagcg ctaagcagca
     2041 gaatcgtggt attcacccaa agcagcaact ccagcttatt ctgtatataa cgctgccctt
     2101 gattatgatt atctcggctg tatttataaa gcaaagcaaa ctgagtcggc tatgcggcag
     2161 agaaagaagc gaaggcacca gctgtataac agaagacagt gtgagtaaca ccaagatgac
     2221 caccaacgaa ggaagcaccc ttcactaacc acctcaagtg ttgccaccca aaaagaagat
     2281 agtctggatt aaccacggga aactggcatt ttgagcaaga ggaaggggaa aaaaccaccc
     2341 ccaaaccaac ccacagcttc tctcccactt ctgcagagat aaatgaggac tctaaaccat
     2401 gaactaataa atcagcggtg gctgaacaaa
//
LOCUS       NM_001436598            2986 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 3, mRNA.
ACCESSION   NM_001436598 XM_063288495
VERSION     NM_001436598.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063288495.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2315385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               JAXUCZ010000005.1  126920187-126920601
            416-488             JAXUCZ010000005.1  126921562-126921634
            489-550             JAXUCZ010000005.1  126921854-126921915
            551-635             JAXUCZ010000005.1  126924241-126924325
            636-695             JAXUCZ010000005.1  127037215-127037274
            696-762             JAXUCZ010000005.1  127040034-127040100
            763-839             JAXUCZ010000005.1  127040190-127040266
            840-904             JAXUCZ010000005.1  127045623-127045687
            905-953             JAXUCZ010000005.1  127046262-127046310
            954-989             JAXUCZ010000005.1  127046896-127046931
            990-1044            JAXUCZ010000005.1  127047469-127047523
            1045-1115           JAXUCZ010000005.1  127048676-127048746
            1116-1194           JAXUCZ010000005.1  127054592-127054670
            1195-1223           JAXUCZ010000005.1  127055509-127055537
            1224-1325           JAXUCZ010000005.1  127055633-127055734
            1326-2986           JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2986
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..415
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream in-frame stop codon"
     CDS             360..1355
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform c is encoded by transcript variant 3;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform c"
                     /protein_id="NP_001423527.1"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEI
                     RWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYPFMSPRYAGG
                     PRPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQ
                     NYGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGP
                     PGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNG
                     SLGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    <627..1283
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    <627..1283
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     exon            416..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..550
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..635
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..695
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..762
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..839
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..904
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..953
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..989
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1044
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1115
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1194
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1223
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1325
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..2986
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagaccag cggcggcggc ggcagaggca gcggtgctga aggcgcagag ggcggcgcag
       61 gcggagccgg gtggcgggcg cgcgggccgc gagcaagcga gctgcaggct tcgggcgggc
      121 ggcggcgcag ctcaggccga gccggcgcgg gaggagttcc agggcgatgg ggccgcggcc
      181 ggggctgacg ctttgacagc tggaaagagc gcggagccag cgccggggag ggagggagcg
      241 cggcgagcgg agtgcgagcg agcgggcgag cgccgggagg gggccgggag cagggcagct
      301 cgggagaccg gacggtagcg gcggcggcgg cgggctcggc gccctcttct ctgcaagcca
      361 tgtttgccaa aggcaaaggc tcggcggtgc cctcggacgg gcaggctcgg gaaaagttag
      421 ctttatatgt ctacgaatat ttactgcacg taggagcaca gaaatctgca cagaccttct
      481 tatcagagat tcgatgggaa aaaaacatca cactgggtga accgcctggg tttctgcact
      541 cgtggtggtg tgtattttgg gacctttact gtgcagctcc tgaaaggaga gacacttgtg
      601 aacattcaag tgaagcaaaa gcctttcatg attacccttt tatgtcaccg agatatgcag
      661 gcggccccag gcccccgatc agaatgggaa accagcctcc aggaggagtt cctgggacac
      721 agccattgct gcccaattcc atggatccca cacgacaaca aggtcacccc aacatgggag
      781 ggtcaatgca gagaatgaac cctccccgag gcatggggcc catggggcct ggcccacaga
      841 attacggcag cggcatgaga ccaccaccca actccctcgg ccccgccatg cctgggatta
      901 acatgggccc aggagctggc agaccctggc ccaatcccaa cagtgctaac tcaatcccgt
      961 actcctcctc atcacccgga acctatgtgg gaccccctgg tggtggcggc cctcctggaa
     1021 cccccatcat gcctagtcct gcggattcaa caaattccag tgacaacatc tacacaatga
     1081 ttaatcctgt gccgcctgga ggcagccggt ctaactttcc aatgggtcct ggctcagatg
     1141 gcccaatggg cggcatggga ggcatggagc cacaccacat gaatggatcc ttaggatcag
     1201 gcgacataga tggacttcca aaaaattctc ctaacaacat aagtggcatt agcaaccctc
     1261 caggcacccc tcgggatgac ggcgagctgg gggggaactt cctccactcc ttccagaacg
     1321 acaattattc tccaagcatg acgatgagtg tgtgatccct tctccacaac gctgagagcc
     1381 ggcattgcag gcagaagatg ccagaaatta tgcaagaaga agtgaggtgt cgataccagg
     1441 agctggggga gggcgtctcc tgctcccctc catccctccc attctctccc ccacctttcc
     1501 caattttagt ttcatgcaat aaaaaggcca aactttttat tccgtcaaac atgaaggaca
     1561 aaactcagaa atatatttca agtcaacgac cagaaaaatc tcaccttctc cctgcccaaa
     1621 aggacctttc tgtacatgac actttttgtt gggttttttt gtttgtttgt ttgtttgttt
     1681 gtttgggatt ttactgttgc tgggatttta aatttgtttt tttgggggga ttctttgggg
     1741 gaattttttt aatggaagct tctagcaagc cctatgccca cccaatcaac ctcattgctt
     1801 tcttctttaa taaaaggaaa aaaggaaaaa gaaaaaaaag gccaaaaaaa aaaaaaaagg
     1861 aagaaaaacc cacaagccct gctgtctatc cccaagtcct accaccagaa aagctagtct
     1921 aggtgtgcaa tatcacactg atgttgtagc catctaaaaa taataataat aaactggaca
     1981 gtttacaatt ggtggtttct ttcaaaagct gtttggggag aaggaactga agtcaacggt
     2041 ttccacgtgg gcctttgggg tttgtgctgg gcaaggagat gcaggtgtcc actttgctct
     2101 ggctgggctg gccatcacaa cacactgggc cagaggaccc agagccccca acttgccgtc
     2161 acccaacaga gaccatcgct gtgacccagc gtacacactg ttccaggatg gctgcctctt
     2221 ctccaaacct ctcatgccca gccacagggg cctccagtcc ctcggtcccc accgtttcct
     2281 ggcaagaatc ctgctggctg ggtagtggcc caggctgtgt aggagaggcc ccaccaacag
     2341 gatgactaca atctgggcca tagaactgac ctccatgttc tggtcccgag ctcctcacat
     2401 agtgcgcact ggcagggcgg gctgaagttg tgtttttctt tttttctcct gtttgtcctt
     2461 tttcaaagat gggtgttggt tggaattgct ctgtatttgc ttggaactgg atggacagac
     2521 ttcagcattg ctgtggggtg gggggagcac cagcaaccaa acagacactg tttctggtcc
     2581 tgtttttatt ttcaaaaact gatgaacctg atggtggagc ctgtcccctc tgaggagggg
     2641 tgacttggct gccctggcct ctccccgtgg caaccattgt gtcttgctcc ggaagacact
     2701 gagttctttg tacatttacc ccctctgtgc cccgcccatc ctcgtagctg gtctttgttt
     2761 tcttacctcc cctttctgac ccatgtatat catattatgt gagataccat ctgcctgaca
     2821 aaagacttgt gcggatcctt gggaacattg tagctgtttc tgtgtttttt cttaccttgt
     2881 agtctggttc tgaattatga gaggaaaaaa agtaattatg atacattgta gtttgtgtac
     2941 gatatatgtt gataacgttt tattaaaggg acatcttttt tccgca
//
LOCUS       NM_001436630            4141 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus DDHD domain containing 2 (Ddhd2), transcript
            variant 4, mRNA.
ACCESSION   NM_001436630 XM_008771368
VERSION     NM_001436630.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4141)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (bases 1 to 4141)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (bases 1 to 4141)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (bases 1 to 4141)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_008771368.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1632195.1,
                                           SRR26643295.52948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000016.1  73022193-73022406
            215-440             JAXUCZ010000016.1  73023386-73023611
            441-631             JAXUCZ010000016.1  73024257-73024447
            632-721             JAXUCZ010000016.1  73025595-73025684
            722-842             JAXUCZ010000016.1  73026637-73026757
            843-932             JAXUCZ010000016.1  73027465-73027554
            933-1068            JAXUCZ010000016.1  73029229-73029364
            1069-1277           JAXUCZ010000016.1  73033702-73033910
            1278-1345           JAXUCZ010000016.1  73034155-73034222
            1346-1468           JAXUCZ010000016.1  73035946-73036068
            1469-1564           JAXUCZ010000016.1  73036977-73037072
            1565-1597           JAXUCZ010000016.1  73038456-73038488
            1598-1753           JAXUCZ010000016.1  73038642-73038797
            1754-1856           JAXUCZ010000016.1  73039438-73039540
            1857-2027           JAXUCZ010000016.1  73039664-73039834
            2028-2187           JAXUCZ010000016.1  73041377-73041536
            2188-2294           JAXUCZ010000016.1  73049473-73049579
            2295-4141           JAXUCZ010000016.1  73049900-73051746
FEATURES             Location/Qualifiers
     source          1..4141
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4141
                     /gene="Ddhd2"
                     /note="DDHD domain containing 2"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
     exon            1..214
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    23..25
                     /gene="Ddhd2"
                     /note="upstream in-frame stop codon"
     exon            215..440
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2269
                     /gene="Ddhd2"
                     /note="isoform 2 is encoded by transcript variant 4;
                     phospholipase DDHD2"
                     /codon_start=1
                     /product="phospholipase DDHD2 isoform 2"
                     /protein_id="NP_001423559.1"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
                     /translation="MSSGESYQEQLSQSDPSPSPNSSSSFELLDMDVGSSYEPVSPHW
                     FYCKVIDSKELWIPFNSEDSQQLEEAHGSGKDCNERVVPTDGGRYDVHLGERMRYAVY
                     WDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKLESPNREI
                     IVLHNPKLMVHYQPITGSDEWGSTSTEQGRPRSVKRGVESIPVDIHCGEPLQIDHLVF
                     VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPL
                     HSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLF
                     LQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSIGDIDSEKGSLSTAEDLGDVSTLEE
                     ELKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSATKSSVGI
                     NRPTMSASEVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPTCKGFFNI
                     YHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSL
                     RMAWKSFTRAPYPALQASEMAEDTEAESEPSSEKPSDANTEEPPVEVKEEAPINVGML
                     NGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
                     "
     misc_feature    347..556
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    347..556
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    1355..1561
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1355..1561
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1619..2230
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    1619..2230
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     exon            441..631
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..721
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..842
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..932
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1068
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1277
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1345
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1468
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1564
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1597
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1753
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1856
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2027
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2187
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2294
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..4141
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctcagg ccctgaaccg ggtgagcgga ctccgcaggg ctcactgctc gcggctggat
       61 cgctgaggag cccgtggtgc gggattgggg cgcggccaca ggctccgccc gtctgcccgc
      121 cccgcccggc ttgggaggta ggctgcagca gggatgtgtc tcggctccct ccgcaagggc
      181 tgagagcgcg agcggcgcgg acaagcgaag ccagagcgaa atgtcatcag gggaatcgta
      241 ccaggagcag ctgtcacagt cagatccatc cccctcccca aactccagta gttccttcga
      301 gctgctagac atggatgttg gcagttccta cgaacccgtt tctccacatt ggttttattg
      361 taaggtaata gactctaagg aactctggat tcctttcaac tctgaagatt cacagcagct
      421 ggaagaagca catggctctg gaaaggattg taatgagaga gttgtcccca ctgatggggg
      481 cagatatgat gtccatctcg gggagaggat gcggtatgcc gtgtactggg atgaactacc
      541 atcagaagtg agacggtgca cgtggtttta caagggagac aaagacaata agtacgtccc
      601 ctactccgag agcttcagcc aagttttgga ggatacatat atgcttgcgg taactctgga
      661 tgaatggaaa aaaaaactag agtctccaaa cagagaaatt attgtattac acaacccaaa
      721 gctcatggtg cattaccagc caatcacagg gtctgatgaa tggggttcaa catccactga
      781 gcaaggtcgg ccaagatcag taaaaagagg cgttgagagc atccctgttg atattcactg
      841 tggggaacct ttacaaatag atcacttagt gtttgtagtc catgggattg gaccagcttg
      901 tgatctccgt tttcgaagca ttgttcaatg tgttaatgat tttcgaagtg tttccttgaa
      961 cctgctacaa acacatttta agaaagccca agaaaaccag cagattggaa gggtagagtt
     1021 ccttccggtc aactggcaca gccctttgca ttctactgga gtagatatag atctgcagcg
     1081 gataacccta cccagcatca atcgccttag acacttcact aacgatacaa ttctggatgt
     1141 cttcttctac aatagcccca cctactgtca gactattgtg gacacagtag cttctgaaat
     1201 gaaccgaata tatacacttt ttctgcagag gaaccctgat ttcaaagggg gtgtatccat
     1261 tgctggtcat agtttaggtt cgcttatatt gtttgatatc ctaacaaatc agaaagattc
     1321 tattggggat attgacagtg aaaagggttc attgagtact gctgaggatc taggagatgt
     1381 atcaacatta gaagaagaac tgaagaagct tcagctctct gagtttgtca ctgtctttga
     1441 gaaggagaaa gttgacagag aagctctggc tttatgtaca gacagagatc ttcaggaaat
     1501 ggggattccc ttaggaccca gaaagaagat actgaaccac ttcagtgcca caaagagttc
     1561 agtgggtatt aatagaccaa ccatgtcagc ttctgaggtg tctgtaaaat acccccggct
     1621 taactacaaa ccagaaatat tctttgcctt tggatctccc attggaatgt ttcttactgt
     1681 ccgaggatta agaagaattg atccaaatta taaatttccc acatgcaaag gtttcttcaa
     1741 tatttaccat ccttttgatc ctgtggcata taggattgaa ccaatggtgg tcccaggagt
     1801 agaatttgag ccaatgctga ttccacatca taaaggcagg aagcggatgc acttagaact
     1861 gagagagggc ttgaccagga tgagtatgga cctgaagaac aacttgctgg gttcactgag
     1921 gatggcctgg aagtctttca ccagagctcc ataccctgcc ttacaagctt cagaaatggc
     1981 agaagacact gaggcagaat ccgaaccaag ttcagaaaag cccagtgacg ccaacacaga
     2041 agagcctcct gtggaggtca aagaggaggc tcccatcaat gtgggaatgc tgaatggagg
     2101 ccagcgcatt gactatgtgt tacaggagaa gcccattgag agttttaatg aatatttatt
     2161 tgctctacaa agccatctat gctactggga atctgaagat acagtactgc ttgtcctcaa
     2221 agagatctac caaacccagg ggatcttcct tgatcagcct ttacagtaaa atgacccatc
     2281 tgtggctgct taatatggac attgagggag cctttcctga aaaccccctc acttgttgct
     2341 gcagctttct tctcagctac cgtgtgtcct gcatgttgcc tgccttactc cacgggatct
     2401 ttcaagataa ccctctttgg aaactaggtg aaagcagagg gaagactgcc tcatatgaac
     2461 tctcgccatt tttgtagcta gggacttcca tatttaatgc tttagcagca gcccctcctt
     2521 ggttattaca tggaaatgga tagtctgtta agggggctta gagagcttta tgtcctctcc
     2581 ttagaaagtg ggcccgttgg ggagcttatg aagatggaga ggacttaggg gtccagtcgc
     2641 actggagggc taagcatgtg tggatgtggg atagctgcta ggttttgagc cagcatttat
     2701 ttctttgctg tgtgtgaaaa ccagaggctg ccctgagcac tcacatggca ctgtagggac
     2761 cactggggct gtttgtggtt gttatagttg cctcagcgtc tgtaacccca gaggctgtat
     2821 gggctgtgtg cctgcccttc tacaccatac tccaaaccag ggtgaagtgc agggagtgag
     2881 gtggtaatac ttacttgaag gtcaccctga agttacatgg tccttctcag ctgttcatgt
     2941 agaaaatgtg gttttttagt agcacggact tgtcacctgc ttcttcactt gagaaaagga
     3001 agtattgtga cataaacgtc actgctttct gaggtatcat caaaatgttt acttatagtt
     3061 ggcagtcagt gtagttgagc atgcaggtta ggcaaggggg aagaccacat tctgaaagaa
     3121 aatcctgtct acagggtctg aggagcagct gtatacactg tgcagtggca gctgaatctg
     3181 cagaattcaa agcacgttta tcctgaggaa gaatgactgt atactgtctt ccccttcctc
     3241 agcatgtgct gtcgtccgtc ctcttcatga ttgtccttta ttctccttag ttagctcctc
     3301 cgatttccac aggtctcttt ataggtgagc tgtggtttga tttttgacct ttttttgtaa
     3361 actgatcatg gtatccagag gcactgcaca taacacgccc tgaagcccct cagatggtgg
     3421 tgcccttgac acaccgggag agggaggcga gcactgtgcc ctggaggtca gaggcacagg
     3481 acagtcaggc ctggccttcc tttctgctta tgggtaatac tggataagca agctactgag
     3541 gagttccagg tatatggaat attttatttt ttctacagta tgtcttgagt aagaatatct
     3601 gagaatgaag tagtattcat taaatactag agtaattttg tcaattgttg tcttgagatt
     3661 tgtttactct tgttagcagt cattactatg ttaagagtaa accaaagcac aactgagtgt
     3721 gttcttgtga ccaaagatgg gcagcttggc cctggagagc tagataaacc actgcactaa
     3781 gaaatgctgc ttcccggcag tccagtacag taactcaaag agcttgcacc tcaccatcca
     3841 ctcgtggcgt tatcacgctc agtattacac aagtgagtag ggcaaggggc ctgggtacgg
     3901 gtgtgcattg cgtcatttgt taccatgtac agtttcttga ccaaggctgt ttttaaactc
     3961 cagtgtaaca gcattttgta cgtaattctg gctacacaat tcgtgagaga ctgtttgcaa
     4021 gggatgaaca gcactgatta ccttcctgat attttgcact tttgaaatgt tttgttttat
     4081 atgtgattat atttaagact ttagtaaatg ctgaaataaa actattgacc atttacctac
     4141 a
//
LOCUS       NM_001318416            4192 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus DDHD domain containing 2 (Ddhd2), transcript
            variant 2, mRNA.
ACCESSION   NM_001318416 XM_006253339
VERSION     NM_001318416.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 18, 2025 this sequence version replaced
            XM_006253339.5, NM_001318416.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2397582.1,
                                           SRR26360190.2084953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000016.1  73022193-73022406
            215-440             JAXUCZ010000016.1  73023386-73023611
            441-631             JAXUCZ010000016.1  73024257-73024447
            632-721             JAXUCZ010000016.1  73025595-73025684
            722-842             JAXUCZ010000016.1  73026637-73026757
            843-932             JAXUCZ010000016.1  73027465-73027554
            933-1068            JAXUCZ010000016.1  73029229-73029364
            1069-1277           JAXUCZ010000016.1  73033702-73033910
            1278-1345           JAXUCZ010000016.1  73034155-73034222
            1346-1468           JAXUCZ010000016.1  73035946-73036068
            1469-1564           JAXUCZ010000016.1  73036977-73037072
            1565-1648           JAXUCZ010000016.1  73038456-73038539
            1649-1804           JAXUCZ010000016.1  73038642-73038797
            1805-1907           JAXUCZ010000016.1  73039438-73039540
            1908-2078           JAXUCZ010000016.1  73039664-73039834
            2079-2238           JAXUCZ010000016.1  73041377-73041536
            2239-2345           JAXUCZ010000016.1  73049473-73049579
            2346-4192           JAXUCZ010000016.1  73049900-73051746
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4192
                     /gene="Ddhd2"
                     /note="DDHD domain containing 2"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
     exon            1..214
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    23..25
                     /gene="Ddhd2"
                     /note="upstream in-frame stop codon"
     exon            215..440
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2320
                     /gene="Ddhd2"
                     /function="lipase"
                     /note="isoform 1 is encoded by transcript variant 2;
                     phospholipase DDHD2"
                     /codon_start=1
                     /product="phospholipase DDHD2 isoform 1"
                     /protein_id="NP_001305345.1"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
                     /translation="MSSGESYQEQLSQSDPSPSPNSSSSFELLDMDVGSSYEPVSPHW
                     FYCKVIDSKELWIPFNSEDSQQLEEAHGSGKDCNERVVPTDGGRYDVHLGERMRYAVY
                     WDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKLESPNREI
                     IVLHNPKLMVHYQPITGSDEWGSTSTEQGRPRSVKRGVESIPVDIHCGEPLQIDHLVF
                     VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPL
                     HSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLF
                     LQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSIGDIDSEKGSLSTAEDLGDVSTLEE
                     ELKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSATKSSVGI
                     NRPTMSASEVNIPKEKGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLR
                     RIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELRE
                     GLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASEMAEDTEAESEPSSEKPSDANTE
                     EPPVEVKEEAPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLV
                     LKEIYQTQGIFLDQPLQ"
     misc_feature    347..556
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    347..556
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    1355..1561
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1355..1561
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1670..2281
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    1670..2281
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     exon            441..631
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..721
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..842
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..932
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1068
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1277
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1345
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1468
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1564
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1648
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1804
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1907
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2078
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2238
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2345
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..4192
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctcagg ccctgaaccg ggtgagcgga ctccgcaggg ctcactgctc gcggctggat
       61 cgctgaggag cccgtggtgc gggattgggg cgcggccaca ggctccgccc gtctgcccgc
      121 cccgcccggc ttgggaggta ggctgcagca gggatgtgtc tcggctccct ccgcaagggc
      181 tgagagcgcg agcggcgcgg acaagcgaag ccagagcgaa atgtcatcag gggaatcgta
      241 ccaggagcag ctgtcacagt cagatccatc cccctcccca aactccagta gttccttcga
      301 gctgctagac atggatgttg gcagttccta cgaacccgtt tctccacatt ggttttattg
      361 taaggtaata gactctaagg aactctggat tcctttcaac tctgaagatt cacagcagct
      421 ggaagaagca catggctctg gaaaggattg taatgagaga gttgtcccca ctgatggggg
      481 cagatatgat gtccatctcg gggagaggat gcggtatgcc gtgtactggg atgaactacc
      541 atcagaagtg agacggtgca cgtggtttta caagggagac aaagacaata agtacgtccc
      601 ctactccgag agcttcagcc aagttttgga ggatacatat atgcttgcgg taactctgga
      661 tgaatggaaa aaaaaactag agtctccaaa cagagaaatt attgtattac acaacccaaa
      721 gctcatggtg cattaccagc caatcacagg gtctgatgaa tggggttcaa catccactga
      781 gcaaggtcgg ccaagatcag taaaaagagg cgttgagagc atccctgttg atattcactg
      841 tggggaacct ttacaaatag atcacttagt gtttgtagtc catgggattg gaccagcttg
      901 tgatctccgt tttcgaagca ttgttcaatg tgttaatgat tttcgaagtg tttccttgaa
      961 cctgctacaa acacatttta agaaagccca agaaaaccag cagattggaa gggtagagtt
     1021 ccttccggtc aactggcaca gccctttgca ttctactgga gtagatatag atctgcagcg
     1081 gataacccta cccagcatca atcgccttag acacttcact aacgatacaa ttctggatgt
     1141 cttcttctac aatagcccca cctactgtca gactattgtg gacacagtag cttctgaaat
     1201 gaaccgaata tatacacttt ttctgcagag gaaccctgat ttcaaagggg gtgtatccat
     1261 tgctggtcat agtttaggtt cgcttatatt gtttgatatc ctaacaaatc agaaagattc
     1321 tattggggat attgacagtg aaaagggttc attgagtact gctgaggatc taggagatgt
     1381 atcaacatta gaagaagaac tgaagaagct tcagctctct gagtttgtca ctgtctttga
     1441 gaaggagaaa gttgacagag aagctctggc tttatgtaca gacagagatc ttcaggaaat
     1501 ggggattccc ttaggaccca gaaagaagat actgaaccac ttcagtgcca caaagagttc
     1561 agtgggtatt aatagaccaa ccatgtcagc ttctgaggta aatatcccca aggaaaaagg
     1621 tgactatttg gatgttggaa ttgggcaggt gtctgtaaaa tacccccggc ttaactacaa
     1681 accagaaata ttctttgcct ttggatctcc cattggaatg tttcttactg tccgaggatt
     1741 aagaagaatt gatccaaatt ataaatttcc cacatgcaaa ggtttcttca atatttacca
     1801 tccttttgat cctgtggcat ataggattga accaatggtg gtcccaggag tagaatttga
     1861 gccaatgctg attccacatc ataaaggcag gaagcggatg cacttagaac tgagagaggg
     1921 cttgaccagg atgagtatgg acctgaagaa caacttgctg ggttcactga ggatggcctg
     1981 gaagtctttc accagagctc cataccctgc cttacaagct tcagaaatgg cagaagacac
     2041 tgaggcagaa tccgaaccaa gttcagaaaa gcccagtgac gccaacacag aagagcctcc
     2101 tgtggaggtc aaagaggagg ctcccatcaa tgtgggaatg ctgaatggag gccagcgcat
     2161 tgactatgtg ttacaggaga agcccattga gagttttaat gaatatttat ttgctctaca
     2221 aagccatcta tgctactggg aatctgaaga tacagtactg cttgtcctca aagagatcta
     2281 ccaaacccag gggatcttcc ttgatcagcc tttacagtaa aatgacccat ctgtggctgc
     2341 ttaatatgga cattgaggga gcctttcctg aaaaccccct cacttgttgc tgcagctttc
     2401 ttctcagcta ccgtgtgtcc tgcatgttgc ctgccttact ccacgggatc tttcaagata
     2461 accctctttg gaaactaggt gaaagcagag ggaagactgc ctcatatgaa ctctcgccat
     2521 ttttgtagct agggacttcc atatttaatg ctttagcagc agcccctcct tggttattac
     2581 atggaaatgg atagtctgtt aagggggctt agagagcttt atgtcctctc cttagaaagt
     2641 gggcccgttg gggagcttat gaagatggag aggacttagg ggtccagtcg cactggaggg
     2701 ctaagcatgt gtggatgtgg gatagctgct aggttttgag ccagcattta tttctttgct
     2761 gtgtgtgaaa accagaggct gccctgagca ctcacatggc actgtaggga ccactggggc
     2821 tgtttgtggt tgttatagtt gcctcagcgt ctgtaacccc agaggctgta tgggctgtgt
     2881 gcctgccctt ctacaccata ctccaaacca gggtgaagtg cagggagtga ggtggtaata
     2941 cttacttgaa ggtcaccctg aagttacatg gtccttctca gctgttcatg tagaaaatgt
     3001 ggttttttag tagcacggac ttgtcacctg cttcttcact tgagaaaagg aagtattgtg
     3061 acataaacgt cactgctttc tgaggtatca tcaaaatgtt tacttatagt tggcagtcag
     3121 tgtagttgag catgcaggtt aggcaagggg gaagaccaca ttctgaaaga aaatcctgtc
     3181 tacagggtct gaggagcagc tgtatacact gtgcagtggc agctgaatct gcagaattca
     3241 aagcacgttt atcctgagga agaatgactg tatactgtct tccccttcct cagcatgtgc
     3301 tgtcgtccgt cctcttcatg attgtccttt attctcctta gttagctcct ccgatttcca
     3361 caggtctctt tataggtgag ctgtggtttg atttttgacc tttttttgta aactgatcat
     3421 ggtatccaga ggcactgcac ataacacgcc ctgaagcccc tcagatggtg gtgcccttga
     3481 cacaccggga gagggaggcg agcactgtgc cctggaggtc agaggcacag gacagtcagg
     3541 cctggccttc ctttctgctt atgggtaata ctggataagc aagctactga ggagttccag
     3601 gtatatggaa tattttattt tttctacagt atgtcttgag taagaatatc tgagaatgaa
     3661 gtagtattca ttaaatacta gagtaatttt gtcaattgtt gtcttgagat ttgtttactc
     3721 ttgttagcag tcattactat gttaagagta aaccaaagca caactgagtg tgttcttgtg
     3781 accaaagatg ggcagcttgg ccctggagag ctagataaac cactgcacta agaaatgctg
     3841 cttcccggca gtccagtaca gtaactcaaa gagcttgcac ctcaccatcc actcgtggcg
     3901 ttatcacgct cagtattaca caagtgagta gggcaagggg cctgggtacg ggtgtgcatt
     3961 gcgtcatttg ttaccatgta cagtttcttg accaaggctg tttttaaact ccagtgtaac
     4021 agcattttgt acgtaattct ggctacacaa ttcgtgagag actgtttgca agggatgaac
     4081 agcactgatt accttcctga tattttgcac ttttgaaatg ttttgtttta tatgtgatta
     4141 tatttaagac tttagtaaat gctgaaataa aactattgac catttaccta ca
//
LOCUS       NM_001436649            3048 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus SPARC/osteonectin, cwcv and kazal like domains
            proteoglycan 3 (Spock3), transcript variant 1, mRNA.
ACCESSION   NM_001436649 XM_063275407
VERSION     NM_001436649.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3048)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   2  (bases 1 to 3048)
  AUTHORS   Nakada,M., Yamada,A., Takino,T., Miyamori,H., Takahashi,T.,
            Yamashita,J. and Sato,H.
  TITLE     Suppression of membrane-type 1 matrix metalloproteinase
            (MMP)-mediated MMP-2 activation and tumor invasion by testican 3
            and its splicing variant gene product, N-Tes
  JOURNAL   Cancer Res 61 (24), 8896-8902 (2001)
   PUBMED   11751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063275407.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.773027.1,
                                           SRR26360176.2015478.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000016.1  31582045-31582092   c
            49-237              JAXUCZ010000016.1  31581357-31581545   c
            238-283             JAXUCZ010000016.1  31413059-31413104   c
            284-398             JAXUCZ010000016.1  31380705-31380819   c
            399-522             JAXUCZ010000016.1  31300481-31300604   c
            523-637             JAXUCZ010000016.1  31266027-31266141   c
            638-757             JAXUCZ010000016.1  31173617-31173736   c
            758-979             JAXUCZ010000016.1  31159816-31160037   c
            980-1042            JAXUCZ010000016.1  31156710-31156772   c
            1043-1180           JAXUCZ010000016.1  31154089-31154226   c
            1181-3048           JAXUCZ010000016.1  31149698-31151565   c
FEATURES             Location/Qualifiers
     source          1..3048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..3048
                     /gene="Spock3"
                     /note="SPARC/osteonectin, cwcv and kazal like domains
                     proteoglycan 3"
                     /db_xref="GeneID:306404"
                     /db_xref="RGD:1305672"
     exon            1..48
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1347
                     /gene="Spock3"
                     /note="testican-3; sparc/osteonectin, cwcv and kazal-like
                     domains proteoglycan 3; sparc/osteonectin, cwcv and
                     kazal-like domains proteoglycan (testican) 3"
                     /codon_start=1
                     /product="testican-3 precursor"
                     /protein_id="NP_001423578.1"
                     /db_xref="GeneID:306404"
                     /db_xref="RGD:1305672"
                     /translation="MLKVSALLCVCAAAWCSQTLAAAAAVAVAGGRSDGGNFLDEKQW
                     LTTVSQYDKEVGQWNKFRDDDYFRTWNPGKPIDQALDPARDPCLKTKCSRHKVCITQD
                     AQTALCISHRRLTHSMKEVGGSHKQWRGLPSSTCKQCPIAYASPVCGSDGHSYSSQCK
                     LEYQACVLGKQISIKCEGRCPCPSDKSMSTGRNVKRACSDLEFREVANRLRDWFKALH
                     ESGSQNKRTKALLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYLD
                     KNEHCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCHTELSKIQKRQGIKKLLGQY
                     LPLCDEDGFYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADCAIDFEISGDFASGDF
                     REWTDDEGEEDDMNDKDDIEDDDEDEGDDDDDGDDHDGYI"
     sig_peptide     49..111
                     /gene="Spock3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    448..588
                     /gene="Spock3"
                     /note="Kazal-type serine protease inhibitor domain;
                     Region: Kazal_2; pfam07648"
                     /db_xref="CDD:400135"
     misc_feature    448..588
                     /gene="Spock3"
                     /note="Kazal-type serine protease inhibitor domain;
                     Region: Kazal_2; pfam07648"
                     /db_xref="CDD:400135"
     misc_feature    640..978
                     /gene="Spock3"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in testican-3 (TICN3); Region: EFh_SPARC_TICN3;
                     cd16239"
                     /db_xref="CDD:320018"
     misc_feature    640..978
                     /gene="Spock3"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in testican-3 (TICN3); Region: EFh_SPARC_TICN3;
                     cd16239"
                     /db_xref="CDD:320018"
     misc_feature    784..879
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    784..879
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    order(820..822,832..834,853..855)
                     /gene="Spock3"
                     /note="putative Ca binding site [ion binding]; other site"
                     /db_xref="CDD:320018"
     misc_feature    order(820..822,832..834,853..855)
                     /gene="Spock3"
                     /note="putative Ca binding site [ion binding]; other site"
                     /db_xref="CDD:320018"
     misc_feature    880..978
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    880..978
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    988..1179
                     /gene="Spock3"
                     /note="Thyroglobulin type-1 repeat; Region:
                     Thyroglobulin_1; pfam00086"
                     /db_xref="CDD:459665"
     misc_feature    988..1179
                     /gene="Spock3"
                     /note="Thyroglobulin type-1 repeat; Region:
                     Thyroglobulin_1; pfam00086"
                     /db_xref="CDD:459665"
     misc_feature    order(1000..1002,1045..1047,1099..1101,1111..1113)
                     /gene="Spock3"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     misc_feature    order(1000..1002,1045..1047,1099..1101,1111..1113)
                     /gene="Spock3"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     exon            49..237
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            238..283
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..398
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..522
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..637
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..757
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..979
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1042
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1180
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..3048
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctttgca tccggaactt gctgcagctg ggattcaggg agaggaagat gctcaaggtg
       61 tcagccttat tgtgtgtgtg tgcagcggct tggtgcagcc agactcttgc agctgctgcg
      121 gcggtggctg tggccggggg gcggtcggac ggcggtaatt ttctggatga aaaacaatgg
      181 ctcaccacag tctctcagta tgacaaggaa gtcggacagt ggaacaaatt ccgagacgat
      241 gattatttcc gcacttggaa tcctggaaaa ccaattgatc aagctttaga tcctgctagg
      301 gacccatgct taaagacgaa atgcagccgc cacaaagtct gcattactca agatgctcag
      361 actgcactgt gcatcagtca ccggaggctc acacacagta tgaaagaagt aggaggaagc
      421 cataagcaat ggagaggtct cccgtcatct acctgtaagc agtgccctat agcctatgcc
      481 agcccggtct gtggttccga tgggcattct tactcttcac agtgcaaact agaatatcag
      541 gcatgtgtct taggaaaaca gatctctatc aaatgtgaag ggcgatgccc gtgtccctcc
      601 gataagtcca tgagcacagg cagaaatgta aagagagcct gcagtgacct ggaattcaga
      661 gaagtggcaa acagactgcg agactggttc aaggcgcttc atgagagtgg aagccagaac
      721 aagaggacaa aagcattgct gaggcctgag agaagcaggt ttgataccag tattttgcca
      781 atttgcaagg attcacttgg ctggatgttt aatagacttg atacaaacta cgacctgtta
      841 ttggaccagt cagagcttgg cagcatttac cttgataaga atgagcattg caccaaggcg
      901 ttcttcaact cttgtgatac atacaaggac agtttgatat ctaacaatga atggtgctac
      961 tgcttccaga gacagcaaga cccaccttgc cacactgagc tcagcaaaat tcagaagcga
     1021 caagggataa agaagctcct aggacagtac ctcccactct gtgatgaaga tggtttctac
     1081 aagccaacac aatgccatgg aagtgtaggg cagtgctggt gtgttgacag atatggaaat
     1141 gaagttgtgg gatctagaat aaatggtgtt gcagattgtg ctatagactt tgagatttct
     1201 ggagactttg caagtggaga ttttcgtgaa tggactgatg atgaaggtga agaagatgac
     1261 atgaatgata aggatgatat tgaagacgat gatgaagatg aaggggatga tgatgatgat
     1321 ggggatgacc acgatggata tatctgacca gtgacaacta atgtcaatga attctacatt
     1381 tttaatattt acaataataa tagcatattg agaatttcct tcttatccct aaacaaagtg
     1441 attctaaacc cgacatatat tttgtataat tatttcaaat attgaagcta aaatcataga
     1501 actttatgtt taaattagaa ttatttagtt tcagttttca tatgccttag aaaaaaagga
     1561 aacacatatg ggttgcagcc tgaatataaa agttgtaaag attactgtaa caaaatttca
     1621 taagaaaata cagacaaata aaataacaat gaatgtgtgc ttgggatcct gtgtgttgct
     1681 tttaatgaca gattttataa gttaaattta tggtagcttg ctaatgacat gaaccacaat
     1741 aatttcatca attaattcct aatgtagatt tcaattcaaa cttaacatct tcccaaacta
     1801 atggttggca tattaagaaa aatggctcat ggtaaaatgg aatggttttc attttaatta
     1861 tgaaattatt ctgggtatta ttagatatta catgcaatgc aacgtgtggt aatccttggg
     1921 tgctgaaagt taaaacctta gtctttcttt ctactttgta attttaatgg cattgcttat
     1981 caggtagaat tttaaaaata ttcctagaca tcctcatttc tagatttctc tctctgacta
     2041 gtaattatgt atagaatttc agttagaaag aaacagactc atttcaacaa ctgttccatt
     2101 aaatatattt tatttgcacc aaggtcaatt ttgaaaccat ggactctcag ttttagtttt
     2161 cattttctat gagattttgc atttgatctt ggaatcatgc cattttttta gtggtactaa
     2221 aattagagac cgtgttgtat ggtgccttgc aaaaatagaa atagaaaggg ttagcatgta
     2281 tatcagtata agagactagg caatgtgtaa gcacacataa ttaacaaatt attgatatta
     2341 aaatagtgct gaaatgaaga aaaatggaat atgtttcttt ctttttttct attgttacat
     2401 aatcccatat ggacttgttt ataattattg tgaagaatag catttaagat taactgtacc
     2461 aaaagttact ttgctcacta tacatcagtt agcatgttaa ttgtgtagat attttgacat
     2521 accaccacct ttgggtatat cagaccaata gttttgtgct cataacagaa gtgggaaaac
     2581 ctgttgaaat ttacacattg atatctttca cttcaacatt gaatttacag atttcctgga
     2641 atattattca taagaacaca aatttggtga actcttgcca tttaatttat atacaagaaa
     2701 taaaaacttt aatcttgaac ttacatataa tatttaagct ataatgtatt ttctttttta
     2761 ttgtttatgt atagtttacg aaataaagaa tcttgtaacc aaagtaaaca gttcttaatg
     2821 attttctggg atatatatat aatagcatga agagttttta atttattcct taactctaca
     2881 aaataacatg ccacaccaga gtcaagaaat atttctgagt ttacttttac agtttgtaaa
     2941 tctgagttgt tattgtatta agtacaataa gattatctat ctttgttggt ttattttaac
     3001 ccgtttattt gtcataatat tgcaaaataa atacttttct ttccaaaa
//
LOCUS       NM_001436605            5622 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 3, mRNA.
ACCESSION   NM_001436605 XM_006238028
VERSION     NM_001436605.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5622)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5622)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5622)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5622)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5622)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5622)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5622)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5622)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5622)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5622)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238028.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.923650.1,
                                           SRR26643429.19114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  60618806-60618840   c
            36-172              JAXUCZ010000005.1  60611539-60611675   c
            173-219             JAXUCZ010000005.1  60609743-60609789   c
            220-486             JAXUCZ010000005.1  60609265-60609531   c
            487-546             JAXUCZ010000005.1  60607510-60607569   c
            547-773             JAXUCZ010000005.1  60605329-60605555   c
            774-877             JAXUCZ010000005.1  60599244-60599347   c
            878-5622            JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5622
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..35
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            36..172
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1032
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform a is encoded by transcript variant 3;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform a"
                     /protein_id="NP_001423534.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MRVCWLVRQDCWHQRIKLPHLEAVVIGRSPETKITDKKCSRQQV
                     QLKAECNKRYVNVKQMGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEV
                     AESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKI
                     SMKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVG
                     EKVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLE
                     SQAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    43..327
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interactions with ADPRT/PARP1 and NCL.
                     /evidence=ECO:0000250"
     misc_feature    46..345
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    46..345
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    order(121..126,160..165,169..171,229..234)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    order(121..126,160..165,169..171,229..234)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    358..489
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    373..387
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    400..402
                     /gene="Aptx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQC5; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); phosphorylation site"
     misc_feature    493..798
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    493..798
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    523..525
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    580..594
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    754..756
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    766..771
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    order(775..777,781..783,787..795)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(775..777,781..783,787..795)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    775..789
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Histidine triad motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00464"
     misc_feature    781..783
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    781..783
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    787..789
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    832..834
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    850..1023
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    850..1023
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            173..219
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            220..486
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            487..546
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            547..773
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            774..877
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            878..5622
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgagagcca agatgcgggt gtgctggttg
       61 gtgagacagg actgctggca ccagcgaatc aaacttcccc atttagaagc tgttgtgatt
      121 ggtcgaagcc cggagaccaa gatcacagat aagaaatgtt cccgacagca agtacagttg
      181 aaagcggagt gtaacaagag atatgtcaac gttaagcaga tgggggtcaa tcccaccagc
      241 attgacgaag tcgtcattgg gaaggaccgg gagatgaagc tgctgcctgg tcaggttctc
      301 cacatggtga atgaacttta tccatacatg gtggagtttg aggaggtggc agagagccct
      361 aacgtaacac agaggaagag aaagaggcca gactgtgata gtcaggagat ggaagctgag
      421 gctggggcca gccccagcca gtgctctgtg tcccctaaga cgggcaagca tggagccgcc
      481 aaggaggaat cactgggcca ctggagtcaa ggcttgaaga tatctatgaa agaccccaaa
      541 atgcaggttt ataaggatga tcaggtggtg gtgattaagg ataaataccc caaggcccgg
      601 caccactggc tggtcttacc atgggcctcc atttccagtc tgaaggttgt gaccagtgaa
      661 cacctcgaac ttctcaaaca catgcacgca gtaggggaaa aggtgatagc agattttact
      721 ggatccagca aactgcgctt ccgactgggt taccatgcca ttcccagcat gagccatgta
      781 catcttcatg tgatcagcca ggattttgat tctccttgcc ttaaaaacaa aaagcattgg
      841 aattctttca atacagaata ttttctggag tcacaagctg tgatcaagat ggttcaggaa
      901 gctggcagag tgactgttaa agatgggact tgcgaactct tgaagctgcc tctccgttgc
      961 catgagtgtc agcagctgct gccttccatc ccacagctga aggagcacct caggaagcac
     1021 tggggcgggt gacactcgcc ttggtgaccg agtgcagtgc tagcatcatt ctgcattgcc
     1081 tgcgctccgt tcagtcctga actaaagcat gcagctcttc aaaacaaagc ttattattct
     1141 tgagtgacca cacagggtga ctctgggtca ggaactggga atatgggttt gtatggtata
     1201 ttttctggta atggaggatg agacatgcct gatcactctt cccaagacca tgtcaggcct
     1261 gactaataag agggcagagc cagcttgagg ttcaaataca agatgtagaa gcagaggact
     1321 ggtaatgtat ttgttcctac ccttgcccct ggatcatgtt ctatcttttt atcaagatag
     1381 ctgaggttct gagggggcct ggttcctgct ctatgatatt cctcttccct ccatgaggag
     1441 gctttcaatc tactgtacca ggctgagtgc ctgggtgaac atatgtggca gtcatctgca
     1501 cagagagata ctttgtgtat gactgtgcca gggaactgga agtggtaata ttgggcacag
     1561 tatgttaaca gtacagcctg tgtcgagggc aaactggggt aatgtgaact gccagtaaac
     1621 agtacatcct ctgctgaggg cagcctgggg cagtgtgaac tgccagtaaa cagtacagcc
     1681 tgtgctgagg gcagcatgga acagtgtgaa ctgttagtga acagtagtct gttctgaggg
     1741 cagccttgta cagtgatgtc agttaacagt gcagtctgtt gagggcatcc tgggatggtg
     1801 tgaactgtca gttaacagtg cagtctgttg agggcatcct gggatggtgt gaactgtcag
     1861 ttaacagtgc agtctgttga gggcatcctg ggatggtgtg aactgtcagt taacagtgca
     1921 gtctgttgag ggcatcctgg gatggtgtga actgtcagtt aacagtgcag tctgttgagg
     1981 gcatcctggg atggtgtgaa ctgtcagtta acagtgcagt ctgtgttgag ggcagcctgg
     2041 gcagtgtgta ttgttagctt caggcagatt ttacggaggc ttcagccact gctcttgaga
     2101 attacagaac atttaactaa acttcggata atgtatctta gaaaaacaga tgttgcaaaa
     2161 tagttcattt actttccacc tgatacaata tagtttagca catcagtatt aaaatgagta
     2221 tttgctgtaa actactagga gtgtctgtat cagacagcgt aagaatgtca ggtataatga
     2281 gaaacatttg gggaatgagg tgaccatgct tacattcttc cttctgccca aaatagattt
     2341 ttttaagact ggggtgagtg catgctgccc ttcctaggac ctgagttttg ttcccggcat
     2401 ccatattagg tggctcacag ctgcctgtag ctccagggat cctgcacctg cttcttgacc
     2461 tctgtgggca ctgcattcaa gtacacaaac ctgaatacag acacacattc acacataatt
     2521 aaatctgtaa aaatcagatc tcgggctgga gagatggctc agtggttaag agctcctcca
     2581 gaggtcctga gttcaattcc cagcaaccac atggtggctc acaaccatct gtaatgggat
     2641 ctgatgccct cttctggtat gcatggagac agccacagtg cacttataca taaataaata
     2701 cataaataaa aaaaatagat ctcttagagg aaaaatgtca ataatgactg gcaggaagca
     2761 ggtattgagg tattgaggtt tattcattcc ctagccctcc tctccgaaat gggcttttat
     2821 caccatgggg aagaagactg tctggactct ggattacttg acagacatgt cattgtacaa
     2881 ttagttgaag ctttccttca gagtcagagg gagggatgtt gggagactgc aaagtagaag
     2941 aaagccagcc acatttaaag ctaggcacag tggcaaattc tcttgcaatc ccaaatttag
     3001 gaggtggtag atccaggagg gccaggcatt ccaggttatc cttgtctata tggtgaactt
     3061 gaggtctgga ctacatgaga ccctatgtca cagaagcaaa taaataaaag atttaaaaag
     3121 gggaaataaa attctatcta aggtaccaaa gcatattatt tggcccatca tggccaggca
     3181 agaccagttg ttatcaaagc agctgttatg gctggaatct gggataactc aggctcatgt
     3241 tctggagcgt gggtcctttc cttgcagtgt tgtttagatg actgtgaagc cattagggtg
     3301 aagccgggct ggcagaagta ggtgtctagg agcaggcagg ccctgaaggc tatacccttt
     3361 cccggctcct ggtgggctgc tttacctcct gtgaacagga cacccatctc tgctactatg
     3421 gactgacact gtgtgtgtgt gcgcgtgcgc acacgcgcgc gcgtgtgtac acaagaggac
     3481 aatttctgga agtcaattgt ctccaccata ttggccctag ggattgactc actagcttga
     3541 ctcagtgtct ttacccactg agttccagta agtcagaagt actcttttaa gaaatagcaa
     3601 cttagggcct ggagtgacgg ctcaggggtt aagagcactg actgctcttc cagaggtcct
     3661 gagttcaatt cccagcaacc acatggtggc tcacaaccat ctgtaacagg atccgattta
     3721 catataataa ataaataaat cttaaaaaaa agaaataact taattctcaa gtacgtacac
     3781 acacacacac acacacacac acacacacac acacacacac actctctctc tctctctcct
     3841 accttatccc aagctaccct aaactcacca tgtagactag gatgaccttg aacttgctga
     3901 gatctgccag tccagagcca gggtactggg attcaagtat cccaccaaag aggaaaataa
     3961 gcaaatgtac aaggattaga tagacattgc ccataattaa ttaaaattca gtgttttctg
     4021 agagtggaaa tattgtcatg aaatattccc ttttgcagca atgctcagat ctgcctcttt
     4081 agaatggtct ttctttttga atgttgctaa tggtgtactg gctggttttg tgtatcaatt
     4141 tggcacacgc tagagtcatc agagaggaag gaccttcagt tgagaaaatg cctccatgag
     4201 ctccagctgt aagacatttt cataattagg gatcagtggg gctagcgcca ttgtgggtgg
     4261 taccactcct ggactggtgg tcctgggtcc tataagaagg caggctgagc aagccagggg
     4321 aagcaagcca gtgtggggtg ggggcacccc actcatggtc tctgcctcag ctcctgtctc
     4381 caggttcctg ctctgtctga gttcctgtcc tggctgcctt tggtggtgaa catgactgct
     4441 gtgtgattgc ctgtctgtca ctcgggcttt atggtatccc agggcattca gaattgggag
     4501 gtgcataatg gagtgttatt taagccataa ataatgaaca gaatggaatt gtgtcctttg
     4561 ccagaagaca gataccctgg aggtcatcct gtgaaacgca atcagccaga ctcagaacag
     4621 tcacctcata ctggtatttc aaaggtcttg gctctcctga ctctatgccc atcgtgaggc
     4681 agagcatagc agaggttgaa gcatgtacaa agccttcttg gcacatggga caaagaggca
     4741 gagacaccac tttgttctga gattggtctt actgtgtagc aaagactgac ctggaattca
     4801 tgcagctcag tttggtcttg agttcaagac ccaactgcct tagcagttct gggtgtgtgc
     4861 taggaagtgt tctcagataa tgttttcaga gcacgagaca ccttcatgtg taggctatca
     4921 tgagtcaact aacctttctg tggctggacc ctgcaggtaa ggggtggagc gcagggcaga
     4981 ggagagactt ctggcactct aaggagcctg tggaccacct agattcttac ctgctgctaa
     5041 catttccaca ccacaggcac cctctagcct atggcagctg ggaacttatt tttgctttca
     5101 agaacccagt gataggtctg tttctcaaat acagctgatg tggctgacct tgagtgaaag
     5161 gagactgaag gttttaggag accccagtat gtagacctga ctgaacttgc ccctgaagct
     5221 gacagcccat tgcatactct tcacatgaat gagaaaaagg tgcctgttgt atgtggaggc
     5281 ctttaaccca gatcccctga ggccggagcc catgtgaggc acaactacat gaccacatag
     5341 ggtgatgtga tggtttgcat atttggccca gggagtggca ctattagaag gtgtggcctt
     5401 gttggaggaa gtgtgtcact gtgggggggt gggcttggag accctcctcc tagctgcctg
     5461 gggatgctca gtctgttcct ggcttccttt ggttgaagat gtagaactca gctcctcctg
     5521 caccaggcct gcctggatgc tgccatgctc ctgccttgat aatggactaa acctctgatc
     5581 tgtaagccag ccctaattaa atgttgtcct ttataaaact ta
//
LOCUS       NM_001436599            2613 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 4, mRNA.
ACCESSION   NM_001436599
VERSION     NM_001436599.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.19867.1,
                                           SRR26643291.15444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000005.1  126995787-126995958
            173-262             JAXUCZ010000005.1  127018017-127018106
            263-322             JAXUCZ010000005.1  127037215-127037274
            323-389             JAXUCZ010000005.1  127040034-127040100
            390-466             JAXUCZ010000005.1  127040190-127040266
            467-531             JAXUCZ010000005.1  127045623-127045687
            532-580             JAXUCZ010000005.1  127046262-127046310
            581-616             JAXUCZ010000005.1  127046896-127046931
            617-671             JAXUCZ010000005.1  127047469-127047523
            672-742             JAXUCZ010000005.1  127048676-127048746
            743-821             JAXUCZ010000005.1  127054592-127054670
            822-850             JAXUCZ010000005.1  127055509-127055537
            851-952             JAXUCZ010000005.1  127055633-127055734
            953-2613            JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2613
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..172
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    128..130
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream in-frame stop codon"
     exon            173..262
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..982
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform d is encoded by transcript variant 4;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform d"
                     /protein_id="NP_001423528.1"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLL
                     PNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINM
                     GPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTM
                     INPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGIS
                     NPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    <260..910
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    <260..910
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     exon            263..322
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..389
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            390..466
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..531
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..580
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..616
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..671
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..742
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..821
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..850
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..952
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            953..2613
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgccctt ctgaagtaga ttcagagagg acggatatgt tcgggaagtt ggagccatca
       61 cctggcacca gaggggagac tcatagccta gtggctccta taaggctctg tgccacccac
      121 atcaaggtag gagctacagg cctcgagacc tggcagaccc tggcatgggc aaagtgcagc
      181 agctgcccca agtcctgtgc ttggcaacat tccccccaat gatgggatgc ctggaggccc
      241 catcccacca ggtttctttc agccttttat gtcaccgaga tatgcaggcg gccccaggcc
      301 cccgatcaga atgggaaacc agcctccagg aggagttcct gggacacagc cattgctgcc
      361 caattccatg gatcccacac gacaacaagg tcaccccaac atgggagggt caatgcagag
      421 aatgaaccct ccccgaggca tggggcccat ggggcctggc ccacagaatt acggcagcgg
      481 catgagacca ccacccaact ccctcggccc cgccatgcct gggattaaca tgggcccagg
      541 agctggcaga ccctggccca atcccaacag tgctaactca atcccgtact cctcctcatc
      601 acccggaacc tatgtgggac cccctggtgg tggcggccct cctggaaccc ccatcatgcc
      661 tagtcctgcg gattcaacaa attccagtga caacatctac acaatgatta atcctgtgcc
      721 gcctggaggc agccggtcta actttccaat gggtcctggc tcagatggcc caatgggcgg
      781 catgggaggc atggagccac accacatgaa tggatcctta ggatcaggcg acatagatgg
      841 acttccaaaa aattctccta acaacataag tggcattagc aaccctccag gcacccctcg
      901 ggatgacggc gagctggggg ggaacttcct ccactccttc cagaacgaca attattctcc
      961 aagcatgacg atgagtgtgt gatcccttct ccacaacgct gagagccggc attgcaggca
     1021 gaagatgcca gaaattatgc aagaagaagt gaggtgtcga taccaggagc tgggggaggg
     1081 cgtctcctgc tcccctccat ccctcccatt ctctccccca cctttcccaa ttttagtttc
     1141 atgcaataaa aaggccaaac tttttattcc gtcaaacatg aaggacaaaa ctcagaaata
     1201 tatttcaagt caacgaccag aaaaatctca ccttctccct gcccaaaagg acctttctgt
     1261 acatgacact ttttgttggg tttttttgtt tgtttgtttg tttgtttgtt tgggatttta
     1321 ctgttgctgg gattttaaat ttgttttttt ggggggattc tttgggggaa tttttttaat
     1381 ggaagcttct agcaagccct atgcccaccc aatcaacctc attgctttct tctttaataa
     1441 aaggaaaaaa ggaaaaagaa aaaaaaggcc aaaaaaaaaa aaaaaggaag aaaaacccac
     1501 aagccctgct gtctatcccc aagtcctacc accagaaaag ctagtctagg tgtgcaatat
     1561 cacactgatg ttgtagccat ctaaaaataa taataataaa ctggacagtt tacaattggt
     1621 ggtttctttc aaaagctgtt tggggagaag gaactgaagt caacggtttc cacgtgggcc
     1681 tttggggttt gtgctgggca aggagatgca ggtgtccact ttgctctggc tgggctggcc
     1741 atcacaacac actgggccag aggacccaga gcccccaact tgccgtcacc caacagagac
     1801 catcgctgtg acccagcgta cacactgttc caggatggct gcctcttctc caaacctctc
     1861 atgcccagcc acaggggcct ccagtccctc ggtccccacc gtttcctggc aagaatcctg
     1921 ctggctgggt agtggcccag gctgtgtagg agaggcccca ccaacaggat gactacaatc
     1981 tgggccatag aactgacctc catgttctgg tcccgagctc ctcacatagt gcgcactggc
     2041 agggcgggct gaagttgtgt ttttcttttt ttctcctgtt tgtccttttt caaagatggg
     2101 tgttggttgg aattgctctg tatttgcttg gaactggatg gacagacttc agcattgctg
     2161 tggggtgggg ggagcaccag caaccaaaca gacactgttt ctggtcctgt ttttattttc
     2221 aaaaactgat gaacctgatg gtggagcctg tcccctctga ggaggggtga cttggctgcc
     2281 ctggcctctc cccgtggcaa ccattgtgtc ttgctccgga agacactgag ttctttgtac
     2341 atttaccccc tctgtgcccc gcccatcctc gtagctggtc tttgttttct tacctcccct
     2401 ttctgaccca tgtatatcat attatgtgag ataccatctg cctgacaaaa gacttgtgcg
     2461 gatccttggg aacattgtag ctgtttctgt gttttttctt accttgtagt ctggttctga
     2521 attatgagag gaaaaaaagt aattatgata cattgtagtt tgtgtacgat atatgttgat
     2581 aacgttttat taaagggaca tcttttttcc gca
//
LOCUS       NM_001436608            5485 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 6, mRNA.
ACCESSION   NM_001436608
VERSION     NM_001436608.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5485)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5485)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5485)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5485)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5485)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5485)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5485)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5485)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5485)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5485)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.19115.1,
                                           SRR26360172.153336.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  60618806-60618840   c
            36-82               JAXUCZ010000005.1  60609743-60609789   c
            83-349              JAXUCZ010000005.1  60609265-60609531   c
            350-409             JAXUCZ010000005.1  60607510-60607569   c
            410-636             JAXUCZ010000005.1  60605329-60605555   c
            637-740             JAXUCZ010000005.1  60599244-60599347   c
            741-5485            JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5485
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..35
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            36..82
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..895
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform b is encoded by transcript variant 6;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform b"
                     /protein_id="NP_001423537.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEVA
                     ESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKIS
                     MKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGE
                     KVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLES
                     QAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    <83..208
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    <83..208
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    356..661
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    356..661
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    order(638..640,644..646,650..658)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(638..640,644..646,650..658)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    644..646
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    644..646
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    713..886
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    713..886
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            83..349
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            350..409
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            410..636
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            637..740
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            741..5485
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgagtacag ttgaaagcgg agtgtaacaa
       61 gagatatgtc aacgttaagc agatgggggt caatcccacc agcattgacg aagtcgtcat
      121 tgggaaggac cgggagatga agctgctgcc tggtcaggtt ctccacatgg tgaatgaact
      181 ttatccatac atggtggagt ttgaggaggt ggcagagagc cctaacgtaa cacagaggaa
      241 gagaaagagg ccagactgtg atagtcagga gatggaagct gaggctgggg ccagccccag
      301 ccagtgctct gtgtccccta agacgggcaa gcatggagcc gccaaggagg aatcactggg
      361 ccactggagt caaggcttga agatatctat gaaagacccc aaaatgcagg tttataagga
      421 tgatcaggtg gtggtgatta aggataaata ccccaaggcc cggcaccact ggctggtctt
      481 accatgggcc tccatttcca gtctgaaggt tgtgaccagt gaacacctcg aacttctcaa
      541 acacatgcac gcagtagggg aaaaggtgat agcagatttt actggatcca gcaaactgcg
      601 cttccgactg ggttaccatg ccattcccag catgagccat gtacatcttc atgtgatcag
      661 ccaggatttt gattctcctt gccttaaaaa caaaaagcat tggaattctt tcaatacaga
      721 atattttctg gagtcacaag ctgtgatcaa gatggttcag gaagctggca gagtgactgt
      781 taaagatggg acttgcgaac tcttgaagct gcctctccgt tgccatgagt gtcagcagct
      841 gctgccttcc atcccacagc tgaaggagca cctcaggaag cactggggcg ggtgacactc
      901 gccttggtga ccgagtgcag tgctagcatc attctgcatt gcctgcgctc cgttcagtcc
      961 tgaactaaag catgcagctc ttcaaaacaa agcttattat tcttgagtga ccacacaggg
     1021 tgactctggg tcaggaactg ggaatatggg tttgtatggt atattttctg gtaatggagg
     1081 atgagacatg cctgatcact cttcccaaga ccatgtcagg cctgactaat aagagggcag
     1141 agccagcttg aggttcaaat acaagatgta gaagcagagg actggtaatg tatttgttcc
     1201 tacccttgcc cctggatcat gttctatctt tttatcaaga tagctgaggt tctgaggggg
     1261 cctggttcct gctctatgat attcctcttc cctccatgag gaggctttca atctactgta
     1321 ccaggctgag tgcctgggtg aacatatgtg gcagtcatct gcacagagag atactttgtg
     1381 tatgactgtg ccagggaact ggaagtggta atattgggca cagtatgtta acagtacagc
     1441 ctgtgtcgag ggcaaactgg ggtaatgtga actgccagta aacagtacat cctctgctga
     1501 gggcagcctg gggcagtgtg aactgccagt aaacagtaca gcctgtgctg agggcagcat
     1561 ggaacagtgt gaactgttag tgaacagtag tctgttctga gggcagcctt gtacagtgat
     1621 gtcagttaac agtgcagtct gttgagggca tcctgggatg gtgtgaactg tcagttaaca
     1681 gtgcagtctg ttgagggcat cctgggatgg tgtgaactgt cagttaacag tgcagtctgt
     1741 tgagggcatc ctgggatggt gtgaactgtc agttaacagt gcagtctgtt gagggcatcc
     1801 tgggatggtg tgaactgtca gttaacagtg cagtctgttg agggcatcct gggatggtgt
     1861 gaactgtcag ttaacagtgc agtctgtgtt gagggcagcc tgggcagtgt gtattgttag
     1921 cttcaggcag attttacgga ggcttcagcc actgctcttg agaattacag aacatttaac
     1981 taaacttcgg ataatgtatc ttagaaaaac agatgttgca aaatagttca tttactttcc
     2041 acctgataca atatagttta gcacatcagt attaaaatga gtatttgctg taaactacta
     2101 ggagtgtctg tatcagacag cgtaagaatg tcaggtataa tgagaaacat ttggggaatg
     2161 aggtgaccat gcttacattc ttccttctgc ccaaaataga tttttttaag actggggtga
     2221 gtgcatgctg cccttcctag gacctgagtt ttgttcccgg catccatatt aggtggctca
     2281 cagctgcctg tagctccagg gatcctgcac ctgcttcttg acctctgtgg gcactgcatt
     2341 caagtacaca aacctgaata cagacacaca ttcacacata attaaatctg taaaaatcag
     2401 atctcgggct ggagagatgg ctcagtggtt aagagctcct ccagaggtcc tgagttcaat
     2461 tcccagcaac cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg
     2521 tatgcatgga gacagccaca gtgcacttat acataaataa atacataaat aaaaaaaata
     2581 gatctcttag aggaaaaatg tcaataatga ctggcaggaa gcaggtattg aggtattgag
     2641 gtttattcat tccctagccc tcctctccga aatgggcttt tatcaccatg gggaagaaga
     2701 ctgtctggac tctggattac ttgacagaca tgtcattgta caattagttg aagctttcct
     2761 tcagagtcag agggagggat gttgggagac tgcaaagtag aagaaagcca gccacattta
     2821 aagctaggca cagtggcaaa ttctcttgca atcccaaatt taggaggtgg tagatccagg
     2881 agggccaggc attccaggtt atccttgtct atatggtgaa cttgaggtct ggactacatg
     2941 agaccctatg tcacagaagc aaataaataa aagatttaaa aaggggaaat aaaattctat
     3001 ctaaggtacc aaagcatatt atttggccca tcatggccag gcaagaccag ttgttatcaa
     3061 agcagctgtt atggctggaa tctgggataa ctcaggctca tgttctggag cgtgggtcct
     3121 ttccttgcag tgttgtttag atgactgtga agccattagg gtgaagccgg gctggcagaa
     3181 gtaggtgtct aggagcaggc aggccctgaa ggctataccc tttcccggct cctggtgggc
     3241 tgctttacct cctgtgaaca ggacacccat ctctgctact atggactgac actgtgtgtg
     3301 tgtgcgcgtg cgcacacgcg cgcgcgtgtg tacacaagag gacaatttct ggaagtcaat
     3361 tgtctccacc atattggccc tagggattga ctcactagct tgactcagtg tctttaccca
     3421 ctgagttcca gtaagtcaga agtactcttt taagaaatag caacttaggg cctggagtga
     3481 cggctcaggg gttaagagca ctgactgctc ttccagaggt cctgagttca attcccagca
     3541 accacatggt ggctcacaac catctgtaac aggatccgat ttacatataa taaataaata
     3601 aatcttaaaa aaaagaaata acttaattct caagtacgta cacacacaca cacacacaca
     3661 cacacacaca cacacacaca cacactctct ctctctctct cctaccttat cccaagctac
     3721 cctaaactca ccatgtagac taggatgacc ttgaacttgc tgagatctgc cagtccagag
     3781 ccagggtact gggattcaag tatcccacca aagaggaaaa taagcaaatg tacaaggatt
     3841 agatagacat tgcccataat taattaaaat tcagtgtttt ctgagagtgg aaatattgtc
     3901 atgaaatatt cccttttgca gcaatgctca gatctgcctc tttagaatgg tctttctttt
     3961 tgaatgttgc taatggtgta ctggctggtt ttgtgtatca atttggcaca cgctagagtc
     4021 atcagagagg aaggaccttc agttgagaaa atgcctccat gagctccagc tgtaagacat
     4081 tttcataatt agggatcagt ggggctagcg ccattgtggg tggtaccact cctggactgg
     4141 tggtcctggg tcctataaga aggcaggctg agcaagccag gggaagcaag ccagtgtggg
     4201 gtgggggcac cccactcatg gtctctgcct cagctcctgt ctccaggttc ctgctctgtc
     4261 tgagttcctg tcctggctgc ctttggtggt gaacatgact gctgtgtgat tgcctgtctg
     4321 tcactcgggc tttatggtat cccagggcat tcagaattgg gaggtgcata atggagtgtt
     4381 atttaagcca taaataatga acagaatgga attgtgtcct ttgccagaag acagataccc
     4441 tggaggtcat cctgtgaaac gcaatcagcc agactcagaa cagtcacctc atactggtat
     4501 ttcaaaggtc ttggctctcc tgactctatg cccatcgtga ggcagagcat agcagaggtt
     4561 gaagcatgta caaagccttc ttggcacatg ggacaaagag gcagagacac cactttgttc
     4621 tgagattggt cttactgtgt agcaaagact gacctggaat tcatgcagct cagtttggtc
     4681 ttgagttcaa gacccaactg ccttagcagt tctgggtgtg tgctaggaag tgttctcaga
     4741 taatgttttc agagcacgag acaccttcat gtgtaggcta tcatgagtca actaaccttt
     4801 ctgtggctgg accctgcagg taaggggtgg agcgcagggc agaggagaga cttctggcac
     4861 tctaaggagc ctgtggacca cctagattct tacctgctgc taacatttcc acaccacagg
     4921 caccctctag cctatggcag ctgggaactt atttttgctt tcaagaaccc agtgataggt
     4981 ctgtttctca aatacagctg atgtggctga ccttgagtga aaggagactg aaggttttag
     5041 gagaccccag tatgtagacc tgactgaact tgcccctgaa gctgacagcc cattgcatac
     5101 tcttcacatg aatgagaaaa aggtgcctgt tgtatgtgga ggcctttaac ccagatcccc
     5161 tgaggccgga gcccatgtga ggcacaacta catgaccaca tagggtgatg tgatggtttg
     5221 catatttggc ccagggagtg gcactattag aaggtgtggc cttgttggag gaagtgtgtc
     5281 actgtggggg ggtgggcttg gagaccctcc tcctagctgc ctggggatgc tcagtctgtt
     5341 cctggcttcc tttggttgaa gatgtagaac tcagctcctc ctgcaccagg cctgcctgga
     5401 tgctgccatg ctcctgcctt gataatggac taaacctctg atctgtaagc cagccctaat
     5461 taaatgttgt cctttataaa actta
//
LOCUS       NM_001436609            5617 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 7, mRNA.
ACCESSION   NM_001436609
VERSION     NM_001436609.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5617)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5617)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5617)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5617)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5617)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5617)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5617)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5617)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5617)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5617)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1030393.1,
                                           SRR26360172.775013.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  60618806-60618840   c
            36-172              JAXUCZ010000005.1  60611539-60611675   c
            173-214             JAXUCZ010000005.1  60609743-60609784   c
            215-481             JAXUCZ010000005.1  60609265-60609531   c
            482-541             JAXUCZ010000005.1  60607510-60607569   c
            542-768             JAXUCZ010000005.1  60605329-60605555   c
            769-872             JAXUCZ010000005.1  60599244-60599347   c
            873-5617            JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5617
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..35
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            36..172
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    116..118
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            173..214
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1027
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform b is encoded by transcript variant 7;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform b"
                     /protein_id="NP_001423538.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEVA
                     ESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKIS
                     MKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGE
                     KVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLES
                     QAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    <215..340
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    <215..340
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    488..793
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    488..793
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    order(770..772,776..778,782..790)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(770..772,776..778,782..790)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    776..778
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    776..778
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    845..1018
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    845..1018
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            215..481
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            482..541
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            542..768
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            769..872
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            873..5617
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgagagcca agatgcgggt gtgctggttg
       61 gtgagacagg actgctggca ccagcgaatc aaacttcccc atttagaagc tgttgtgatt
      121 ggtcgaagcc cggagaccaa gatcacagat aagaaatgtt cccgacagca agttgaaagc
      181 ggagtgtaac aagagatatg tcaacgttaa gcagatgggg gtcaatccca ccagcattga
      241 cgaagtcgtc attgggaagg accgggagat gaagctgctg cctggtcagg ttctccacat
      301 ggtgaatgaa ctttatccat acatggtgga gtttgaggag gtggcagaga gccctaacgt
      361 aacacagagg aagagaaaga ggccagactg tgatagtcag gagatggaag ctgaggctgg
      421 ggccagcccc agccagtgct ctgtgtcccc taagacgggc aagcatggag ccgccaagga
      481 ggaatcactg ggccactgga gtcaaggctt gaagatatct atgaaagacc ccaaaatgca
      541 ggtttataag gatgatcagg tggtggtgat taaggataaa taccccaagg cccggcacca
      601 ctggctggtc ttaccatggg cctccatttc cagtctgaag gttgtgacca gtgaacacct
      661 cgaacttctc aaacacatgc acgcagtagg ggaaaaggtg atagcagatt ttactggatc
      721 cagcaaactg cgcttccgac tgggttacca tgccattccc agcatgagcc atgtacatct
      781 tcatgtgatc agccaggatt ttgattctcc ttgccttaaa aacaaaaagc attggaattc
      841 tttcaataca gaatattttc tggagtcaca agctgtgatc aagatggttc aggaagctgg
      901 cagagtgact gttaaagatg ggacttgcga actcttgaag ctgcctctcc gttgccatga
      961 gtgtcagcag ctgctgcctt ccatcccaca gctgaaggag cacctcagga agcactgggg
     1021 cgggtgacac tcgccttggt gaccgagtgc agtgctagca tcattctgca ttgcctgcgc
     1081 tccgttcagt cctgaactaa agcatgcagc tcttcaaaac aaagcttatt attcttgagt
     1141 gaccacacag ggtgactctg ggtcaggaac tgggaatatg ggtttgtatg gtatattttc
     1201 tggtaatgga ggatgagaca tgcctgatca ctcttcccaa gaccatgtca ggcctgacta
     1261 ataagagggc agagccagct tgaggttcaa atacaagatg tagaagcaga ggactggtaa
     1321 tgtatttgtt cctacccttg cccctggatc atgttctatc tttttatcaa gatagctgag
     1381 gttctgaggg ggcctggttc ctgctctatg atattcctct tccctccatg aggaggcttt
     1441 caatctactg taccaggctg agtgcctggg tgaacatatg tggcagtcat ctgcacagag
     1501 agatactttg tgtatgactg tgccagggaa ctggaagtgg taatattggg cacagtatgt
     1561 taacagtaca gcctgtgtcg agggcaaact ggggtaatgt gaactgccag taaacagtac
     1621 atcctctgct gagggcagcc tggggcagtg tgaactgcca gtaaacagta cagcctgtgc
     1681 tgagggcagc atggaacagt gtgaactgtt agtgaacagt agtctgttct gagggcagcc
     1741 ttgtacagtg atgtcagtta acagtgcagt ctgttgaggg catcctggga tggtgtgaac
     1801 tgtcagttaa cagtgcagtc tgttgagggc atcctgggat ggtgtgaact gtcagttaac
     1861 agtgcagtct gttgagggca tcctgggatg gtgtgaactg tcagttaaca gtgcagtctg
     1921 ttgagggcat cctgggatgg tgtgaactgt cagttaacag tgcagtctgt tgagggcatc
     1981 ctgggatggt gtgaactgtc agttaacagt gcagtctgtg ttgagggcag cctgggcagt
     2041 gtgtattgtt agcttcaggc agattttacg gaggcttcag ccactgctct tgagaattac
     2101 agaacattta actaaacttc ggataatgta tcttagaaaa acagatgttg caaaatagtt
     2161 catttacttt ccacctgata caatatagtt tagcacatca gtattaaaat gagtatttgc
     2221 tgtaaactac taggagtgtc tgtatcagac agcgtaagaa tgtcaggtat aatgagaaac
     2281 atttggggaa tgaggtgacc atgcttacat tcttccttct gcccaaaata gattttttta
     2341 agactggggt gagtgcatgc tgcccttcct aggacctgag ttttgttccc ggcatccata
     2401 ttaggtggct cacagctgcc tgtagctcca gggatcctgc acctgcttct tgacctctgt
     2461 gggcactgca ttcaagtaca caaacctgaa tacagacaca cattcacaca taattaaatc
     2521 tgtaaaaatc agatctcggg ctggagagat ggctcagtgg ttaagagctc ctccagaggt
     2581 cctgagttca attcccagca accacatggt ggctcacaac catctgtaat gggatctgat
     2641 gccctcttct ggtatgcatg gagacagcca cagtgcactt atacataaat aaatacataa
     2701 ataaaaaaaa tagatctctt agaggaaaaa tgtcaataat gactggcagg aagcaggtat
     2761 tgaggtattg aggtttattc attccctagc cctcctctcc gaaatgggct tttatcacca
     2821 tggggaagaa gactgtctgg actctggatt acttgacaga catgtcattg tacaattagt
     2881 tgaagctttc cttcagagtc agagggaggg atgttgggag actgcaaagt agaagaaagc
     2941 cagccacatt taaagctagg cacagtggca aattctcttg caatcccaaa tttaggaggt
     3001 ggtagatcca ggagggccag gcattccagg ttatccttgt ctatatggtg aacttgaggt
     3061 ctggactaca tgagacccta tgtcacagaa gcaaataaat aaaagattta aaaaggggaa
     3121 ataaaattct atctaaggta ccaaagcata ttatttggcc catcatggcc aggcaagacc
     3181 agttgttatc aaagcagctg ttatggctgg aatctgggat aactcaggct catgttctgg
     3241 agcgtgggtc ctttccttgc agtgttgttt agatgactgt gaagccatta gggtgaagcc
     3301 gggctggcag aagtaggtgt ctaggagcag gcaggccctg aaggctatac cctttcccgg
     3361 ctcctggtgg gctgctttac ctcctgtgaa caggacaccc atctctgcta ctatggactg
     3421 acactgtgtg tgtgtgcgcg tgcgcacacg cgcgcgcgtg tgtacacaag aggacaattt
     3481 ctggaagtca attgtctcca ccatattggc cctagggatt gactcactag cttgactcag
     3541 tgtctttacc cactgagttc cagtaagtca gaagtactct tttaagaaat agcaacttag
     3601 ggcctggagt gacggctcag gggttaagag cactgactgc tcttccagag gtcctgagtt
     3661 caattcccag caaccacatg gtggctcaca accatctgta acaggatccg atttacatat
     3721 aataaataaa taaatcttaa aaaaaagaaa taacttaatt ctcaagtacg tacacacaca
     3781 cacacacaca cacacacaca cacacacaca cacacactct ctctctctct ctcctacctt
     3841 atcccaagct accctaaact caccatgtag actaggatga ccttgaactt gctgagatct
     3901 gccagtccag agccagggta ctgggattca agtatcccac caaagaggaa aataagcaaa
     3961 tgtacaagga ttagatagac attgcccata attaattaaa attcagtgtt ttctgagagt
     4021 ggaaatattg tcatgaaata ttcccttttg cagcaatgct cagatctgcc tctttagaat
     4081 ggtctttctt tttgaatgtt gctaatggtg tactggctgg ttttgtgtat caatttggca
     4141 cacgctagag tcatcagaga ggaaggacct tcagttgaga aaatgcctcc atgagctcca
     4201 gctgtaagac attttcataa ttagggatca gtggggctag cgccattgtg ggtggtacca
     4261 ctcctggact ggtggtcctg ggtcctataa gaaggcaggc tgagcaagcc aggggaagca
     4321 agccagtgtg gggtgggggc accccactca tggtctctgc ctcagctcct gtctccaggt
     4381 tcctgctctg tctgagttcc tgtcctggct gcctttggtg gtgaacatga ctgctgtgtg
     4441 attgcctgtc tgtcactcgg gctttatggt atcccagggc attcagaatt gggaggtgca
     4501 taatggagtg ttatttaagc cataaataat gaacagaatg gaattgtgtc ctttgccaga
     4561 agacagatac cctggaggtc atcctgtgaa acgcaatcag ccagactcag aacagtcacc
     4621 tcatactggt atttcaaagg tcttggctct cctgactcta tgcccatcgt gaggcagagc
     4681 atagcagagg ttgaagcatg tacaaagcct tcttggcaca tgggacaaag aggcagagac
     4741 accactttgt tctgagattg gtcttactgt gtagcaaaga ctgacctgga attcatgcag
     4801 ctcagtttgg tcttgagttc aagacccaac tgccttagca gttctgggtg tgtgctagga
     4861 agtgttctca gataatgttt tcagagcacg agacaccttc atgtgtaggc tatcatgagt
     4921 caactaacct ttctgtggct ggaccctgca ggtaaggggt ggagcgcagg gcagaggaga
     4981 gacttctggc actctaagga gcctgtggac cacctagatt cttacctgct gctaacattt
     5041 ccacaccaca ggcaccctct agcctatggc agctgggaac ttatttttgc tttcaagaac
     5101 ccagtgatag gtctgtttct caaatacagc tgatgtggct gaccttgagt gaaaggagac
     5161 tgaaggtttt aggagacccc agtatgtaga cctgactgaa cttgcccctg aagctgacag
     5221 cccattgcat actcttcaca tgaatgagaa aaaggtgcct gttgtatgtg gaggccttta
     5281 acccagatcc cctgaggccg gagcccatgt gaggcacaac tacatgacca catagggtga
     5341 tgtgatggtt tgcatatttg gcccagggag tggcactatt agaaggtgtg gccttgttgg
     5401 aggaagtgtg tcactgtggg ggggtgggct tggagaccct cctcctagct gcctggggat
     5461 gctcagtctg ttcctggctt cctttggttg aagatgtaga actcagctcc tcctgcacca
     5521 ggcctgcctg gatgctgcca tgctcctgcc ttgataatgg actaaacctc tgatctgtaa
     5581 gccagcccta attaaatgtt gtcctttata aaactta
//
LOCUS       NM_001436651            3405 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus zinc finger protein 362 (Zfp362), transcript
            variant 2, mRNA.
ACCESSION   NM_001436651 XM_063287287
VERSION     NM_001436651.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063287287.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               JAXUCZ010000005.1  146437281-146437882 c
            603-728             JAXUCZ010000005.1  146426100-146426225 c
            729-792             JAXUCZ010000005.1  146421491-146421554 c
            793-1039            JAXUCZ010000005.1  146421103-146421349 c
            1040-1367           JAXUCZ010000005.1  146417641-146417968 c
            1368-1592           JAXUCZ010000005.1  146416686-146416910 c
            1593-1671           JAXUCZ010000005.1  146407848-146407926 c
            1672-1830           JAXUCZ010000005.1  146407561-146407719 c
            1831-3405           JAXUCZ010000005.1  146403469-146405043 c
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3405
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="zinc finger protein 362"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
     exon            1..602
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            603..728
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    685..687
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="upstream in-frame stop codon"
     CDS             691..1947
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 362 isoform a"
                     /protein_id="NP_001423580.1"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
                     /translation="MSRSSPSGKGPSRMAEPRFNNPYFWPPPPTMPSQLDNLVLINKI
                     KEQLMAEKIRPPHLPPTSASSQQPLLVPPAPAESSQAVMSLPKLQQVPGLHPQSVPQP
                     DVALHARPATSTVTGLGLSSRTPAVSTSESTPGTGTGTSTPSTPTTTSQSRLIASSPT
                     LISGITSPPLLDSIKTIQGHGLLGPPKSERGRKKIKAENPGGPPVLVVPYPILASGET
                     AKEGKTYRCKVCPLTFFTKSEMQIHSKSHTEAKPHKCPHCSKSFANASYLAQHLRIHL
                     GVKPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHN
                     KDKPYKCPNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHT
                     VVEHLVSHHSPQRTESPGIPVRISLI"
     misc_feature    <769..>1083
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <769..>1083
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    1369..1431
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1369..1431
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1405..1482
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1405..1482
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1447..1515
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1447..1515
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1453..1515
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1453..1515
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1468..1470,1474..1476,1480..1482,1486..1491,
                     1498..1503,1510..1512,1552..1554,1558..1560,1570..1575,
                     1582..1587,1594..1596,1642..1644,1648..1650,1654..1656,
                     1660..1665,1672..1677,1684..1686)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1468..1470,1474..1476,1480..1482,1486..1491,
                     1498..1503,1510..1512,1552..1554,1558..1560,1570..1575,
                     1582..1587,1594..1596,1642..1644,1648..1650,1654..1656,
                     1660..1665,1672..1677,1684..1686)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1489..1566
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1489..1566
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1537..1599
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1537..1599
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    <1603..1761
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <1603..1761
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    1621..1689
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1621..1689
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1711..1773
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1711..1773
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1807..1863
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1807..1863
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            729..792
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1039
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1367
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1592
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1671
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1830
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..3405
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactcgcc ggagccccgg ggccgggcgg gctgcgcagc cgagaggcgg ggggccggac
       61 gcggctcgct cgccgggccc agcgcaccgg ggccgcgcgg ctgcacagcc ggcctccgcc
      121 gccgcggcgc ctgcagaacc cagaagtgaa cagcaggcga cccggaaggt ttgcgcgccg
      181 ctccgcaccg agccccagcc gcgcgccgcc gctaccgccg ccgccgccga agccgggagc
      241 ccccagcccg gccctactcg ggccgccggg ctcggggctg cggccgcgtc ccggagcgcc
      301 gccagcactg ccaggtccgt gcgggcccgg ggcgcgcggg ggagcgggcc cgcccgcggg
      361 aaagttgcgc cgagttgcgg ggcgggggcc gggcgggcgc gagcgctgtc agcgcggggc
      421 ggtcgcgctg cgtgggcccg ggggtcgccg gtgcctcggg cccggccccg gggcggccgc
      481 ggcggcgacg gctgcgcgcg cggggtaggc agcgtctccc gcggcgtgtc tggggctggt
      541 ctccgagtgt gtgcgtgtgt gttttcctaa gccgggctat tcaaacctgc tgcaattctc
      601 cggtgccgtt gggaacacag aggaagtgac tgactggggg ttcagggaaa gctccgtaga
      661 agagggaaca cttgagctgg gtcttgaagg atgagtagaa gttcaccaag tgggaaagga
      721 ccctctagga tggccgaacc tcgatttaac aacccatact tctggccccc tcctcccacc
      781 atgcccagcc agctggacaa cctggtcctg attaacaaga tcaaagagca gctgatggcc
      841 gagaaaatcc ggccgcctca cctgccaccc acctcagcct cgtcacagca gccactgcta
      901 gtgccccccg cgcccgccga gagcagtcag gcggtcatgt cgctgcccaa gctgcagcag
      961 gtgcccgggc tgcacccgca gtccgtgccg cagcccgacg tggcgctgca cgcgaggccg
     1021 gccaccagca ctgtcacagg tctggggctt tcctctcgga cccccgctgt gagtacatct
     1081 gagtcaaccc caggcacggg cacaggcacc agtaccccat ccacacccac caccaccagc
     1141 cagagccgcc tcatcgcctc atcccccacc ctcatctcag ggatcaccag cccccccctc
     1201 ctggactcca tcaagacaat ccagggccac ggcctgcttg gcccccccaa gtctgaacgc
     1261 ggccgcaaaa agatcaaggc agagaaccca gggggtcccc ctgtccttgt tgtcccctac
     1321 cccatcctgg cctccggtga gaccgccaag gagggcaaga catacaggtg taaggtatgc
     1381 ccgctcacct ttttcaccaa gtctgagatg cagatccact ccaagtcgca caccgaggcc
     1441 aagccccaca agtgcccaca ctgctccaag tcctttgcca atgcctccta cctggcccag
     1501 catctgcgca tccacctggg tgtcaagccc taccactgct cctactgtga caagtccttc
     1561 cggcagctct cccacctcca gcagcacacc agaatccaca caggcgacag accctacaag
     1621 tgcccacatc ctggctgcga aaaggctttc actcaactct ccaacctcca gtctcaccag
     1681 cgtcagcaca ataaggacaa gccctacaaa tgtcccaact gctaccgggc ctactcagac
     1741 tccgcctccc tccagatcca cctctccgcc catgccatca agcacgccaa ggcctactgc
     1801 tgcagcatgt gcgggcgggc ctacacctcg gagacctacc tgatgaagca catgtccaaa
     1861 cacacagtgg tggaacacct ggtgagccat cactcacccc agaggaccga gtcccccggc
     1921 atcccggtgc gaatctctct gatctgagcc cacctgtggt gccgccccgc ccacttggca
     1981 gcacccagcc taactcccgc tggggcctcc aggaaccacc aagctctctc acgacctacc
     2041 caacctgcca gaaagcttgg tccatagaag ccctgcctga tccggctcct gggcagccag
     2101 gccaactgca agattctggg ctgttctggt ggcatccaaa gacgatctca gagcactttg
     2161 aacctgtctg tcgggttttc tttctttttt tttttttttt ttgttccccc tccctcactt
     2221 gcttcactgt ctcttgtttt tttttttttt aaagtttgtt ttggaaataa caaaaaggat
     2281 atttattggc cagaatgttg gtgctgctaa gaacgagaga ttcaaaggac tggacggacg
     2341 gatacagaga gaaccagagg gcagcgtggg aacttctctg accacaacct caggtcttga
     2401 ggggaggcct ggggttctgg acttcaaagg ggactccctc cctcaggtgg gaagagacag
     2461 gaggcagctg gagtgagccc ttcgtccctg tcacccagtc aaactgcctg agctttgccc
     2521 tagcccttgt gagcagcggg tacagcagct gccacctgcc tggctttagg ggatggaaaa
     2581 tgagagaggt ctggagagcc gcgggaccaa agggtgcagt gacggctggg tggcgagccc
     2641 agggaatggg ctgggggtgt gccaggtgag acctggcccc tcccctgctg ccctgaagac
     2701 caccccagtc tacctcggtg ctggccagga aacctatcgg ctacctctcc caccactcca
     2761 gactgtgggc aaggggatgg agagggaggg ggcctgggac taagtgccct tcccagaatt
     2821 tcctccagaa gggtacagtg cccagggagg ggttgtcctt ctctccacgg atgagacggg
     2881 gactccccca acccagaccc caggccctgc ggcagggata ggagcctctg aaggaggccc
     2941 caggagcaga ccctgccccc agccccccaa gacatatccc aatccgaaag ccatgcgtgt
     3001 ccgtgtatat aggaactatg tacagaaccc agagaagccc ccttccacat cacccccaga
     3061 gaagaaaact agacaaaact catctatata ttctgtatct ggagtccgtt tgaatattaa
     3121 ctgtgttatt tttatacact ttttaagcct taactcgcca ttgatttacc agtttaacgt
     3181 ttcctggggt ttcttttcca ctgggagggg tctcagcccc ccacccaccc caaccccttc
     3241 gtttgacttg cgtcgtctga tactcagtat tgtagctttc gtccgcatgt tactaccctg
     3301 taaatatgct gttccaatac cgttggcatc ctttgctttt ttctatggga cctccaggcc
     3361 accatattta gaaatagtta ccttattaaa aaagagaaaa cagtc
//
LOCUS       NM_001106640            5704 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 63 (Gpr63), transcript
            variant 3, mRNA.
ACCESSION   NM_001106640 XM_001060842 XM_232847
VERSION     NM_001106640.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5704)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_001106640.2.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000005.1  43478030-43478298
            270-5704            JAXUCZ010000005.1  43518406-43523840
FEATURES             Location/Qualifiers
     source          1..5704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5704
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
     exon            1..269
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     exon            270..5704
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    394..396
                     /gene="Gpr63"
                     /note="upstream in-frame stop codon"
     CDS             418..1695
                     /gene="Gpr63"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 63"
                     /protein_id="NP_001100110.1"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
                     /translation="MVVSGVLTAPAVLTTPHTGTSNMTFVVYENSPMNITAPLPFQHP
                     SPGPLLRYSLETMTSTGFSSLAVNSTVVTPAPAVFKSLNLALQIILSAIMIFILFVSF
                     LGNLVVCLMVYQKAAMRSAINILLASMAFADMLLAVLNMPFALVTILTTRWIFGKFFC
                     RLSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATAFSVAFP
                     LAVGNPDLQIPSRAPQCVFGYTTNSGYQAYVILISLISFFIPFLVILYSFMGILNTLR
                     HNALRIHSYPEGICLSQVSKLGLMSLQRPFQMSIDMSFKTRAFTTILILFAVFIVCWA
                     PFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMM
                     PKSFKFLPRLPGHTRRRIRPSAVYVCGEHRTVL"
     misc_feature    679..1581
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    679..1581
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    682..762
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    682..762
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    781..858
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    781..858
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    order(847..849,856..861,895..912,916..921,928..930,
                     1054..1056,1060..1074,1150..1152,1159..1167,1171..1179,
                     1183..1188,1414..1416,1423..1428,1432..1437,1444..1446,
                     1480..1485,1489..1497,1504..1506,1513..1518)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    order(847..849,856..861,895..912,916..921,928..930,
                     1054..1056,1060..1074,1150..1152,1159..1167,1171..1179,
                     1183..1188,1414..1416,1423..1428,1432..1437,1444..1446,
                     1480..1485,1489..1497,1504..1506,1513..1518)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    895..987
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    895..987
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    1012..1080
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    1012..1080
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    1150..1239
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1150..1239
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1354..1446
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1354..1446
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1483..1560
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
     misc_feature    1483..1560
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
ORIGIN      
        1 tgtgggtgct gggaatcgaa cctgggtcct ccgggtgatc atccagtgct cttaaccggt
       61 gagccatctt tccagtccta cgtattatgt ttttggttcc agttcttagg actggaggtg
      121 ctggatatgt atggctcttt ttgttgaatt ctgtttgaga tctgctgaga caaattgttc
      181 tgtatcacca gttctttgat gcttgttagt gctgtgggct ccagcaggca ttctgtttca
      241 gtaaaagttt cactgtcact gtggaaacag caaacagatt cttgtggaag atggagctgt
      301 gtccattttc cagaatgtgc atccgagccc atcagtggaa cctgacctga cagcactgta
      361 tggaaatgcc cgaagaggac ccacatttct gcctgaacct gccaccctcc taaaaacatg
      421 gttgtctccg gagtgttgac tgctccggca gtgttgacta caccccatac tgggacatcc
      481 aacatgacat ttgtagtcta tgaaaactcc cccatgaata ttacggcccc tctaccattt
      541 cagcatccta gccctggtcc actgcttaga tacagtcttg aaaccatgac tagcactgga
      601 tttagttcct tggcagtgaa cagcacagtg gtgactccag caccagcagt ttttaagagc
      661 ctaaacttag ctctccagat cattctctcg gctatcatga tatttattct gtttgtgtct
      721 tttcttggaa atttggttgt ttgcctcatg gtttaccaaa aggccgccat gcgctctgca
      781 attaacatcc ttctcgccag catggctttt gcagacatgc tgcttgctgt attgaacatg
      841 ccctttgccc tggtcactat tcttactacc agatggatat ttgggaagtt cttctgccgg
      901 ttgtctgcta tgtttttctg gttgtttgtg atagagggtg tggccatcct gctcattatt
      961 agtattgata ggttcctgat tattgttcag aggcaagata agctaaatcc atacagggct
     1021 aaggttctca ttgcagtctc ctgggcaact gctttttctg tagcttttcc tctggctgtg
     1081 ggaaaccctg atctgcagat accttccaga gccccacagt gtgtatttgg gtatacaacc
     1141 aactccggct atcaggctta tgtgattttg atttcactaa tttccttctt tatacctttc
     1201 ctggtgatac tctattcatt tatgggcatc ctcaacaccc ttcggcacaa tgccttgagg
     1261 attcatagct acccggaagg gatatgcctc agccaggtca gcaaacttgg tctcatgagt
     1321 ctacagagac ccttccaaat gagcatcgac atgagtttta aaacacgtgc cttcaccacc
     1381 attttgatcc tctttgccgt cttcattgtc tgctgggccc cattcaccac ctacagcctt
     1441 gtggctacct tcagtaagca cttttactat cagcacaact tctttgagat tagcacctgg
     1501 ctactctggc tctgctacct caagtctgca ttgaacccac tgatatacta ctggaggatt
     1561 aagaagtttc acgatgcctg cttggacatg atgcccaagt ccttcaagtt cttgccacgg
     1621 ctccctggtc acacaaggcg acggattcgc cctagtgcgg tctatgtgtg tggggagcat
     1681 cggacggtgt tgtgaatacc tgaactcttg agacctatct aatgatgatg gtttttgatt
     1741 gactgggatt tttttcatat ggcttctaaa gttttattgg ttttaatagt atgtgtgcgt
     1801 gtgtgggggc atgtaaacgg aatggtaaat actttgctcc tcaaaccaag gtaatactgt
     1861 aagaaagtgg tcacatatgt ttacctctag gttaagaaaa ttttagcgca cgcgtgcgcg
     1921 cgcgcgtgtg tgtgtgtatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgg
     1981 gggtggattt tgttagttca gttgactggt tttatttttg tagcatgaat caggattgtg
     2041 cttcattgaa cttgcagtta acttgaattg taggtggttt ttatgctgct gaggtaagct
     2101 tggttgaggt aatcagttcc ttttcctctc ccacaagcca cagcggctgc tccttgccat
     2161 gtactggagt caaatccctc tgcatctcag ttggtagcta tttagttgta tttaaaaaca
     2221 aaacccgagg aggttagtga cgttttaaag gttattacac tttactttgg agcactttac
     2281 gagacaatgt acagactcat tcgttgtatt tcttagactt gcttttacac atgacatgct
     2341 gtgctgtggg agatctgcgc ttatgatgtc tagatagaca gcttccatta aaagtgtttt
     2401 agctgcatgt acagttttaa agggaacata aacacatagg gattttccta agcacaacgg
     2461 tgagttttca gagcacccag gaaacattga ggaggcacag caccatggca aacttcacgg
     2521 aggagcagaa tgagagggtg ggctggtcca gcctgtggtc atcctgctga ttcaaacatc
     2581 gttaccaact tagagtgggg ggaccaccac tctgcagtgg tgcggtatgc acggaattgc
     2641 gcagtttttt ctcatggctt tttttgtgag gtaggtatca tatatttcct ctctaaaggt
     2701 gaagaaggcc aagtttccga gggacaaaaa tcctgcccag agattttgga atttggcaga
     2761 gctgggctcc agacatctga gatacagaca cagatcttcc cctgtgccac ctagacccct
     2821 cactcacctt caagctgcta tactcaaggg gaacttcact acttcacttc acatattctt
     2881 tttttgttct ctctctctct ctctctctct ctctctctct ctttctcttt tcctttctga
     2941 gacatcattt catgaagctc aagtaggcct tgaagttgct atatgtctgg gaaagacatg
     3001 gagtttctaa aagaaacaaa cagcagaccc agcctttcaa atggaactca aaaatatgac
     3061 gatgaatatg aatttgaatt tataaggcaa gtgacttaca gttactgagt gctcaataca
     3121 gctgaatggg gggtcttacc ccagcagctt tggaagttcc tagcaattca gctgatcagt
     3181 agtagggcct tttgcctcag ggcttgcctc agcagagtaa gttgtgaaca aactcaggta
     3241 agtcttccac agtgaagaga cgataaaccc tggtctgagc ttagattaac tgtgatagat
     3301 caggctttgg atttctcatt ctttttcttt agttgtctgc cagtgctggt gcatccagaa
     3361 ccttcatcag cttctcagtt acccatggta cagacagaac agccagcagg agcggaactg
     3421 cagactgaag gcaagaggcc ttctgactgt cctgggctaa ggcagtatct taactcagtt
     3481 ggacagcacc ttttcggaat tttactgctt tctgagccac tgggaaaaac aagcctgggt
     3541 tccttcaatt acagaaaccc aagttagttt gcaagaattg ctaaggtttt acccaaccct
     3601 gaggtttttt tattgtctgt ccttgttgcc cctcccactc tcccatatac aagtatagtt
     3661 ggaagagccc agccaacggc ataactattg tctggtctcc agtattactt tacatttgct
     3721 ttgttagctc ttttcttaaa atgggtgtct gatgctctct ggcttcgtga tcaggaattg
     3781 ggatgttgga aatttgtttg caacaccaaa cacctgggaa atcctgattt tgatgccatt
     3841 tgaggcaatt gcaatggtgt tgtaattcac cagctgctta aatagcttta gggactagtg
     3901 aacactattt gccacattat gttaaggtca ctgcatatgt tagccaccta cctctttgat
     3961 ttctaattta tatttagcaa aggtaaatat gtctttgtcc gttaggatat tagtagatat
     4021 tagcagtaca ttgaaatgca ttttgttttc cattgccaat gtaaactgaa ttttaaaggc
     4081 cgatattaat acagatgttg aaagttcaac tttcaggaaa gacagcgttg tgaatatcga
     4141 tgcatactgg tagcttttga gtcttctttt gtgactctag ttgaacttgg tttcacatct
     4201 gtgttcttgc ttatgtgcag ttgaaggtac tgtcttctgg ttcataggca gctacacttg
     4261 gggagtgctc tgggaagact gcagagccaa catgaacagc catgggggag gggacattga
     4321 atcgtagctc tctttacact ggataatctg gtcagactac agtttacaca tcactttaac
     4381 tattttaatt atatatacat tttgaaagtt ttaggaaaaa acactatggt gcaacattaa
     4441 ggaatttagg tataaaattg cacattgcct attattctgt catttcttga tggggaaaac
     4501 accactacta accactgctg actgacataa tcagaaaagt tttccttcta gctaatagga
     4561 tacatgaaag agataagaaa atatttgttg ttgttaaaaa acaaaaaaga gtgaagagaa
     4621 atttcaaata gtttgcagca gtaatattta aatttaatac atgtttgaat atcctcagga
     4681 aggctaacaa tacaaattcc tgggcccctg ggtcaatggt tggatgcagg aatgtttatt
     4741 tctgttgagt attttgcctg attctggttc agatggtccc cagagcacag ttacaagaaa
     4801 cactcctgta gaaaataaga atatcattta aacactgttt gcgttatctt aaagtagttg
     4861 tgtgttagga gccaatggtg atacacaatg aaaggaagtc tccatgatgg gtgccttctg
     4921 gttggtttgt atgctggtgc agatttggcc agcaccagct ttactttctt ttcactggtg
     4981 aagtctgatg aaccatgtgg tttcacagta ggggtcaacg aatgactcac taattgtaag
     5041 tcatgacttc cacaaggcta attagtatag tattttttcc tgcagatgtc tctatagggc
     5101 atctcttcat tatatgtaat ttcctgggga gagaggggga aatgtaaagg ctcatctgat
     5161 tcctaattct ctgctcagac cagttgttca gctgaagcat gaagtgaaat aagataatct
     5221 ttaaatcttc gtacttttgt tggtgacaga gatatttaat ttctttgatc tttgctttgt
     5281 ttacatgaga atgtataggt atagatcaca aacatttcca cctgcttgct attttattct
     5341 gtcatgattt ttatttgact tcaaattact aatagtttca aatttatttc cataaccata
     5401 attttgagga actgaacttc aactccattg aagacacaac ttttataata ataaaaatat
     5461 caaagcacat gtttgttatc gcaaataaat gttagtacac ttcttagcta tctataggta
     5521 cttgtcattt gtaattaaaa ttaatttatt ttaaaatggc acctagcctt taaatgaatg
     5581 aaaagctttt aatttgaggt tgtaacattt aaatatcaaa agtatgttta tttgttaata
     5641 ttcttattac aaccaagaaa agagctacca ataagaaaat gaataaatgt ttactatttc
     5701 taaa
//
LOCUS       NM_001436656            6314 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 7 (Slc26a7),
            transcript variant 5, mRNA.
ACCESSION   NM_001436656 XM_039109421
VERSION     NM_001436656.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6314)
  AUTHORS   Kiriya,M., Kawashima,A., Fujiwara,Y., Tanimura,Y., Yoshihara,A.,
            Nakamura,Y., Tanigawa,K., Kondo,T. and Suzuki,K.
  TITLE     Thyroglobulin regulates the expression and localization of the
            novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes
  JOURNAL   Endocr J 69 (10), 1217-1225 (2022)
   PUBMED   35644541
  REMARK    GeneRIF: Thyroglobulin regulates the expression and localization of
            the novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes.
REFERENCE   2  (bases 1 to 6314)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6314)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            acid challenge represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   4  (bases 1 to 6314)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   5  (bases 1 to 6314)
  AUTHORS   Kosiek,O., Busque,S.M., Foller,M., Shcheynikov,N., Kirchhoff,P.,
            Bleich,M., Muallem,S. and Geibel,J.P.
  TITLE     SLC26A7 can function as a chloride-loading mechanism in parietal
            cells
  JOURNAL   Pflugers Arch 454 (6), 989-998 (2007)
   PUBMED   17404755
  REMARK    GeneRIF: SLC26A7 is a Cl(-) uptake system under histamine
            stimulation
REFERENCE   6  (bases 1 to 6314)
  AUTHORS   Petrovic,S., Amlal,H., Sun,X., Karet,F., Barone,S. and Soleimani,M.
  TITLE     Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7
            in kidney medullary collecting ducts of Brattleboro rats
  JOURNAL   Am J Physiol Renal Physiol 290 (5), F1194-F1201 (2006)
   PUBMED   16352747
  REMARK    GeneRIF: vasopressin increases the expression of SLC26A7 protein
            through posttranscriptional mechanisms in the outer medullary
            collecting duct
REFERENCE   7  (bases 1 to 6314)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
REFERENCE   8  (bases 1 to 6314)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   9  (bases 1 to 6314)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 6314)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039109421.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.875782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1429              JAXUCZ010000005.1  32794634-32796062   c
            1430-1540           JAXUCZ010000005.1  32786927-32787037   c
            1541-1713           JAXUCZ010000005.1  32780136-32780308   c
            1714-1878           JAXUCZ010000005.1  32757312-32757476   c
            1879-2031           JAXUCZ010000005.1  32743404-32743556   c
            2032-2114           JAXUCZ010000005.1  32734765-32734847   c
            2115-2262           JAXUCZ010000005.1  32732596-32732743   c
            2263-2376           JAXUCZ010000005.1  32730466-32730579   c
            2377-2454           JAXUCZ010000005.1  32721568-32721645   c
            2455-2550           JAXUCZ010000005.1  32720536-32720631   c
            2551-2657           JAXUCZ010000005.1  32712705-32712811   c
            2658-2724           JAXUCZ010000005.1  32704950-32705016   c
            2725-2832           JAXUCZ010000005.1  32703539-32703646   c
            2833-2970           JAXUCZ010000005.1  32701574-32701711   c
            2971-3019           JAXUCZ010000005.1  32698486-32698534   c
            3020-3120           JAXUCZ010000005.1  32689483-32689583   c
            3121-3175           JAXUCZ010000005.1  32685795-32685849   c
            3176-3279           JAXUCZ010000005.1  32685608-32685711   c
            3280-6314           JAXUCZ010000005.1  32681653-32684687   c
FEATURES             Location/Qualifiers
     source          1..6314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..6314
                     /gene="Slc26a7"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
     exon            1..1429
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1396..1398
                     /gene="Slc26a7"
                     /note="upstream in-frame stop codon"
     exon            1430..1540
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             1519..3315
                     /gene="Slc26a7"
                     /note="isoform c is encoded by transcript variant 5; anion
                     exchange transporter; solute carrier family 26 (anion
                     exchanger), member 7"
                     /codon_start=1
                     /product="anion exchange transporter isoform c"
                     /protein_id="NP_001423585.1"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
                     /translation="MGRHVATGTFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLS
                     EFELQRIGVAAAVSFLGGVIQLVMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVK
                     YLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRK
                     IKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEA
                     FGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTA
                     GLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLK
                     KYWNVDKIDWGIWISTYIFTICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEM
                     ELKVKTETYDNTENWPPSKSTNVKVFPGSLKTGSNVRSLSVTPRRMENSQQIKIISIN
                     NPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCP
                     SEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLD
                     TEKPIFFDSVATAISVIQSNKNLSKDTDHSEV"
     misc_feature    1525..3255
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    1525..3255
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     exon            1541..1713
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1878
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2031
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2114
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2262
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2376
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2454
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2550
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2657
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2724
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2832
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2970
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3019
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3120
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3175
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3279
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..6314
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaactct ctactgcctt ccagctggta gcatttggtt atgtgacatg tgtcaagaag
       61 aaattattct gtacctttct cacaagccac agaaatgatt tgtttttaga tgcatttgca
      121 acatgttcct atctggaatg ctgccccttt ctccactgcc accacctgga tattggtggg
      181 actttcctag ctttccatat accacatatc ctctatggca atgtctgata aaggcaaaag
      241 gaagccttcc tttaaagaaa aatagtctcc taataacatt catcaaattc agggtgatag
      301 caagatcatt ttgtagtctt ctttgaatat gcttaaatag tatagaattt ttaaactcat
      361 aatacaaaat ctcccctaat ggatgtataa aaacactagt ctccttgtat tgtcatggca
      421 atcatgtaat cctgaaacct gtttgtatgt gtcatgcata tcacagattc tacctcccga
      481 tcaatggaga tagtttcaac tcagacattt taacagctgt aaataattcc atagcacaat
      541 tgtaacaaaa tcctactctt tatatagtga tgcatattta gctaattgtt gtttaatcat
      601 aacttaactt attagcacat agtagtagga attggcaccc aggcctctat atgaagttgc
      661 acacgtatag agggctgtct cttacctaca tcttgtcatt tcctgtcact gtgggtagtc
      721 tttcctcttc cactcccaga cactagttcc taccagccaa tgttatttgc catgagggac
      781 aagaagtgac cctggcctgg gtagttagaa accgtatctt tctagataca atgttaataa
      841 taatttgctc ctgtggtaca gagcatactg ctttaagagc ttttattatg cttcaacagt
      901 aaaagatgta agtttgtaag tttggtcatc attttctaac atgtcacttt gaagttctca
      961 cattttgcat ttaaaatttt ttatttttga tactataaaa taattacacc atttactccc
     1021 tccaacctcc ccccacatat ccgccctact cattttgtta aaattgtaga tggaaggcag
     1081 tgagaataca gtgggtcacc ctgatggtga cctttgtcct ctaacctcca ttttttgctt
     1141 cgtcatataa ccctaattta cattgatatg gtaaaaaatt taaagtttta aatcagagaa
     1201 aaattatgca tcatcactct ctttctttca acttctcaca tatcctagtc tatcattttc
     1261 cctgcagggt gcagtgagtt ctaatatgat ttgattttcc tcctttaacc acttccctta
     1321 ggttagctct ggtcagggtt tgggtgactg ctgaggcctc caggaggagc aaacaagaac
     1381 ccacggatgg agccgtagat tcattgttgg ccaagtccag gctgtagagg gctgtccttc
     1441 gctattcttt catctgtaca cccagttttt ggtttatacg gatctctgtt tcctgccatc
     1501 atttatgcga tatttggaat gggacgccat gttgccacag gcacctttgc cttgacgtcc
     1561 ttgatatcag ccaatgctgt ggaacggctg gtccctcaga gcaatagaaa cctcaccaca
     1621 cagagcaact caagcgtgct gggcttatcg gagtttgagc tgcagagaat cggggttgca
     1681 gcagccgttt cattcttggg cggagtgatt cagctggtca tgtttgtgct gcagctaggc
     1741 aatgccacat tcctgcttac ggagccagtg atcagtgcca tgaccaccgg cgctgccacc
     1801 catgttgtga cgtcacaagt caagtatctc ttgggaataa aaatgccata tatatctgga
     1861 ccactgggat tcttttatat ctatgcgtat gtttttgaga acatcaagtc tgtccagctg
     1921 gaagcactgc tcttgtcctt gctgagcatt gttgtccttg tcctcgttaa agagctgaac
     1981 gagcagttta agagaaagat taaagttgtt cttcctgtcg acttagtttt gatcattgct
     2041 gcctcatttg cttgctattg taccaacatg gaaaacacat acggattaga agtagttggg
     2101 cgcattccaa aagggatccc tccgccccgt gctcccccaa tgaacatcct ctccgcagtg
     2161 ctcacggaag ctttcggagt tgcacttgta ggctacgtgg cctcgctggc tctcgcacaa
     2221 ggatctgcca agaagttcaa atattcagtt gatgacaacc aggaattttt ggcccatggc
     2281 ctcagcaacg tgattccttc atttctcttc tgcatcccaa gcgccgccgc catgggaagg
     2341 acagctggtc tgtacagcac gggggcaaag acacaggtgg cttgtctaat atcttgcatt
     2401 ttcgtcctta tagtcatcta tgcaatagga cccttgctgt actggctgcc catgtgcgtt
     2461 cttgcaagta ttattgttgt gggactgaaa ggaatgttaa tacagttccg ggatttaaaa
     2521 aaatactgga atgtggataa aatcgattgg ggcatatgga tcagcactta catttttaca
     2581 atatgcttcg ctgccaacgt gggactgctc tttggtgttg tctgcaccat agctatcgtg
     2641 ttagggcgtt tcccaagggc aaagacttta agcataacag acatgaaaga aatggaattg
     2701 aaggtgaaga cagaaacgta tgataacaca gagaactggc ctccttccaa aagcaccaat
     2761 gtcaaggtct ttccaggtag cctgaaaaca ggaagtaacg tcaggagtct ttctgtgaca
     2821 cccaggagaa tggaaaactc gcaacagata aaaatcatct caataaacaa cccacttgtt
     2881 ttcctgaatg caaagaaatt tagtgctgat cttatgaaaa taatcctaaa ggaaactgac
     2941 ggcagccaag cacttgatga tgtcagcaag tgtgaacaga acaccttgct cagtcccctg
     3001 cccaacggga gctgcactga agaagcctcc cagccctgcc ccagtgagaa gtattctttg
     3061 gtcctgaatt gcagtggctt gacctttttc gactacacag gagtctccac acttgttgag
     3121 ctctaccttg attgcaagag caggagtgtg gatgtgttct tagccaactg tacagcatcc
     3181 ttgataaaag cgatgacata ctatggagac ctagacactg aaaaaccaat tttttttgac
     3241 tcggtagcca ctgcaataag tgtcatccaa tcaaataaga atttgagcaa ggacactgac
     3301 cacagtgaag tctgaggtcc acgcattgaa atgcacatct catctttagc acctgcccca
     3361 aagaggccag atactggcat tttgcactca ttttggtgta tatactgtat atctcttaat
     3421 tagaatgatg tgagttggca actggatagc cactggccaa gacttgctga catcctattt
     3481 tttctaattt ttcttaataa acagattcat tagttatttc atataggcat caatatgcat
     3541 gtagctttag tttaatgaac agtaaacatg cttttatttc cagttataag agtattttgt
     3601 atggtttcat ttttgttgta agctaacaaa tggagaaata tttttatcag aaatggtttg
     3661 gattatttat aaaccattca taaaaaaatt aagatcatct agtacataaa aaagtattaa
     3721 caaatgtgcc atttctccat agtttttatc ccaaaattat ttgaacatca gttagataaa
     3781 gtatcacttt tatacaggga aaatgaaatc catagatata aaacaagtga gaaagagaca
     3841 aattagaagt tattaatgtc aatgcccatc aacacactca ctctgacaat attcatatat
     3901 tcaattatga gttcatattt ggaagaaaac taatgtttta gcaaaactaa gttcttgatg
     3961 tttatctgct gaattgtgga tactggagac catttgtgtg tttaatcaga taactctgac
     4021 ttctgcattg caacacataa gatattctgc tttcaaactt ctttcttgca atcagagaat
     4081 atgagaattt gatatgtatt ttttcaaaaa tatgcatttt tcaatgataa aatatcataa
     4141 gtagaatgct tttgtgcttt tggatacaag attaaccctt agaaattttg aattttctat
     4201 ttgagatata aaaagtcaac aaaatataat atgttattga tctataccaa gatagataga
     4261 ttgaagatag aacgacagac agacagacag aagacaggta gacaacagac agatgacaga
     4321 cagatctcca aggtatgttt tccattttct tttgttagag atgagcttga atgtgattat
     4381 acgtaaattt gctaatacaa taggataatt tataacacta atggccagat ataagtgtaa
     4441 acatttttca tacttgtata ttttattttt atctatatac aagaatgaaa tttcacaatt
     4501 ttttaaacaa attgtcttat atatgaagcc acagattaaa ttatgattta tccttaatag
     4561 catctaaaac attctacaaa gttagtaacg ctgtcagaaa aaaaaaaaac aaaacacaaa
     4621 aaaaaaaaaa acagcaaagg gagtttgaaa agcaagttaa aaattggcct tctggtgtgg
     4681 ttcttatggg catctgtaag agcaaattct aactcctgtc caaatgacag agtggaatag
     4741 tccttcgcca gtgcaaggta aacatttaca caatccactg ttttaacacc tcactctttg
     4801 gcaggatgaa ataataagtg aaaactaaaa atagcgctct aaattttcat ggtcattttc
     4861 aatttttact gaaacaaatt caaaagtctt gttcccccaa attgccccaa tttcttcatc
     4921 acttattggg gtagtaccaa gtaaggtgac cagtattgct catcagatag gtttctaagg
     4981 gaagtctgag ggagaattag aaaggagttt tattctgcgt catccacttc ccttactcta
     5041 tacgtgcaga gtggtggact ctaccttgta atcaggagtc atgcgaagcc aagaaaagaa
     5101 atagattatg gtgcatagaa agtgatattt tgctatacaa atttgacctt aattaaattc
     5161 atgagttgta ggcattttta atttgttgta gatgatgggc cttgggtgac attaaagtca
     5221 ttatagctat ttgttggata gtttttctgt ttcgttgtga atgctcagac agtattgtct
     5281 gagaaactgc atctgagtgc atttaagtat aagcttaatg cataaaaagt caaccccatc
     5341 aatttcagta tcaaacattg ttacagccaa aacaagaaag acaagaccac acactgtata
     5401 aagtccactg ctctatagtt tatgccaaga ccacaatctt tttaacccaa agaaagtctc
     5461 ttaattaagg tccaaggctc caagaactgc acataagttt tagacataca agtgtttatt
     5521 tcaaagcaga ctcagagagc agagaagcta caacatggct ctagtgttgt aatattttct
     5581 atcagcacac tgacctattc tgagggggcc atgttaattt tatatgataa actccttccg
     5641 tagtacttat tatagtaaaa taacatagaa aactgaccta tacgagtgtt aagaacctaa
     5701 tatggcagat atgaaatatg taaccaggaa aaactgttaa cattaaacat cacatttatg
     5761 caaattaaat gcccttaaaa ttttgccatt cgtctttcat ttttaaaggt tatttgccct
     5821 caattatgta atttcagtgt tataaagttt agcttaaact actttgcaat aatttatttg
     5881 acagatctcc gttctataaa ccatgcaatg taatgaggcc agagatcttt cttttttaat
     5941 gaaaacatta acatgttaat atcccacatg aatgatgctt gacattcaac gattgtcgaa
     6001 atatgttggt atgttgctga acatacacac acctctgaaa tgccagttct gcgttctgtg
     6061 ggctgatgat ctgactcatc gtgtgacata tgctttctgg cagtgagttc attgccagag
     6121 tttaaacagg gagttacggt gctcatggcg ctttcagaac ccaaagattt gtggtttgga
     6181 atcatgtagt ctagtatgct gcacttattt ttatattttt aatgcactta attattgttt
     6241 ttacaattat ttgtactaac tcagcatgta acaaccaatt tacatggaaa taaattgaaa
     6301 tatgataact acaa
//
LOCUS       NM_001436648            4129 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus chondroitin sulfate
            N-acetylgalactosaminyltransferase 1 (Csgalnact1), transcript
            variant 4, mRNA.
ACCESSION   NM_001436648 XM_063275379
VERSION     NM_001436648.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Sato,T., Kudo,T., Ikehara,Y., Ogawa,H., Hirano,T., Kiyohara,K.,
            Hagiwara,K., Togayachi,A., Ema,M., Takahashi,S., Kimata,K.,
            Watanabe,H. and Narimatsu,H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is
            necessary for normal endochondral ossification and aggrecan
            metabolism
  JOURNAL   J Biol Chem 286 (7), 5803-5812 (2011)
   PUBMED   21148564
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Watanabe,Y., Takeuchi,K., Higa Onaga,S., Sato,M., Tsujita,M.,
            Abe,M., Natsume,R., Li,M., Furuichi,T., Saeki,M., Izumikawa,T.,
            Hasegawa,A., Yokoyama,M., Ikegawa,S., Sakimura,K., Amizuka,N.,
            Kitagawa,H. and Igarashi,M.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required
            for normal cartilage development
  JOURNAL   Biochem J 432 (1), 47-55 (2010)
   PUBMED   20812917
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Gotoh,M., Sato,T., Akashima,T., Iwasaki,H., Kameyama,A.,
            Mochizuki,H., Yada,T., Inaba,N., Zhang,Y., Kikuchi,N., Kwon,Y.D.,
            Togayachi,A., Kudo,T., Nishihara,S., Watanabe,H., Kimata,K. and
            Narimatsu,H.
  TITLE     Enzymatic synthesis of chondroitin with a novel chondroitin sulfate
            N-acetylgalactosaminyltransferase that transfers
            N-acetylgalactosamine to glucuronic acid in initiation and
            elongation of chondroitin sulfate synthesis
  JOURNAL   J Biol Chem 277 (41), 38189-38196 (2002)
   PUBMED   12163485
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063275379.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1353958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000016.1  25762253-25762375
            124-182             JAXUCZ010000016.1  25772977-25773035
            183-241             JAXUCZ010000016.1  25798380-25798438
            242-376             JAXUCZ010000016.1  25843836-25843970
            377-525             JAXUCZ010000016.1  25915023-25915171
            526-1453            JAXUCZ010000016.1  26002429-26003356
            1454-1670           JAXUCZ010000016.1  26052126-26052342
            1671-1772           JAXUCZ010000016.1  26065782-26065883
            1773-1951           JAXUCZ010000016.1  26079602-26079780
            1952-2046           JAXUCZ010000016.1  26080645-26080739
            2047-2128           JAXUCZ010000016.1  26091895-26091976
            2129-4129           JAXUCZ010000016.1  26095306-26097306
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4129
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
     exon            1..123
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            124..182
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            183..241
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            242..376
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            377..525
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1453
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    817..819
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="upstream in-frame stop codon"
     CDS             826..2418
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /EC_number="2.4.1.174"
                     /note="chondroitin beta1,4
                     N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001423577.1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
                     /translation="MVRRGLVGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLP
                     RANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGQDQASDAT
                     SLRSGWDPEPKAQADILAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETG
                     LTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRPYTAADFIEGIYRTERDK
                     GTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKKEKLNMANTLINVIVPLARRVDKFRH
                     FMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSR
                     GKGLDVGARFWKGSNVVLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGI
                     IYGHHDAVPALEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVH
                     LYRKYLHSNLIVIRTPVRGLFHLWHEKHCMDELTPEQYRMCMQSKAMNEASHGQLGML
                     VFRHEIEAHLRKQKLKASSKKT"
     misc_feature    1027..2340
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     misc_feature    1027..2340
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     exon            1454..1670
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1772
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1951
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2046
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2128
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..4129
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgttgga actggaggtg gagccgagcc cagggccgcc tcgcaggagg gaaagttcgg
       61 cggcgccggg cgggagcagc gtagccaagg gagccggctc cgctgtctgc agggttgctt
      121 ggggtctcgt tttcctcctg gaatacagcg tgtgcagatg gatcaaagtt acctactata
      181 aagttcctgc ctttgagttc ttgctccaac ttccctcagt gatggagtgc aatgtggaaa
      241 ggtcccttga tcatgaatga cagattgaag agttgccatg tggatctaca gtcctcaatg
      301 tgagaagctt taaacaatct tttctatggc tggaatcctc aaatgttcta cttaattgcc
      361 tctggagcat caccagtggt ggcgctgagc tgaacacggt gctagcagaa gggggcggta
      421 ctttccctct ggaccctgac ttggaagcca agtgcgactc gagcgcagtc accgccagaa
      481 gcagatgtgt gagcggagca gctgtgcgcc tctctttctg ccgaggatcc ccctcatctt
      541 cagcacatca ggaagactat gatggaaaca aaagaaagaa cttggaggtt ccacttaact
      601 gattgtttct gcctagagga tcttctcttg gaagcaggag agccttctca tgtaatggct
      661 gacttccaaa gacaggctat gttctagaag gaaatggatg gaatcagttc aggggacttc
      721 agccgcactg tggtctaacc agaaaagccc gtgttggggg ccctcctggt gccctgggat
      781 gttgcatact ctggacctgg atgcatggcc cgcacctgag tgaggatggt ccgacgcggg
      841 ctggtggggt ggatttcccg ggtagtgatt ctgctggtgc tgctctgttg tgccatctct
      901 gttctctaca tgttagcctg caccccaaaa ggcgaccaag agcagctggg actgccacgg
      961 gccaacggcc ccacaggcaa agatggctac caagcggtgc tacaggagcg tgaggaacag
     1021 catcgcaact atgtgaatag tcttaagcga cagatcgcgc agctcaagga tgaactgcag
     1081 gcacgcagtg agcagctccg cagtgggcag gaccaggcca gcgatgccac cagcctgcgg
     1141 tcaggctggg accctgaacc caaagcccag gctgatatac tggccttcct gcgtgggcag
     1201 gtggacaagg ctgaggtcca cgccggtgtc aagctggcca ccgaatatgc tgctgtgcct
     1261 tttgatagct tcactctgca gaaagtatac cagctggaga ctggtctgac ccgccaccct
     1321 gaggagaaac cagtgaggaa ggacaagcga gatgagctag tggaagctat cgaatcagcc
     1381 ctggagagtc taaacagccc tgtggaaagc agcccacacc agcgccctta cacggctgca
     1441 gacttcatag aagggatcta ccgaacagaa agggataaag gcactttgta tgagctgacc
     1501 ttcaaagggg accataagca tgaattccaa cgacttgtcc tatttcgacc ttttggcccc
     1561 atcatgaaag tgaagaagga aaagctcaac atggccaaca cacttatcaa cgttatcgtg
     1621 cccctagcga ggagggtgga caagttccgg cacttcatgc agaacttcag ggagatgtgc
     1681 atccaacaag atgggagagt tcatcttacc gttgtttatt ttgggaaaga agaaatgaat
     1741 gaagtcaaag gaatacttga aaacacttcc aaggctgcca attttagaaa cttcaccttc
     1801 atccagctga atggagagtt ctcccgggga aagggactgg atgttggagc ccgcttctgg
     1861 aagggaagta atgtcgtgct ctttttctgt gatgtggaca tctacttcac ctctgagttc
     1921 ctcaacacat gtaggctgaa cacacagcca gggaagaagg tattttatcc ggttcttttc
     1981 agtcagtata accctggcat aatctacggc catcatgatg ctgtccctgc cctagaacag
     2041 cagctggtca taaagaagga aacaggattt tggagggact ttggattcgg aatgacttgt
     2101 cagtaccggt cagacttcat caacataggt ggatttgacc tggacatcaa aggctggggc
     2161 ggtgaagatg tgcacctgta ccggaaatat ctccatagca acctcatagt gatacgcacg
     2221 cctgtacggg gacttttcca cctttggcat gagaagcact gtatggatga actgacccct
     2281 gagcagtaca ggatgtgcat gcaatcaaag gctatgaatg aagcatccca cgggcagctg
     2341 ggaatgcttg tcttccggca tgaaatagag gctcaccttc gcaaacagaa gctcaaagcc
     2401 agcagtaaaa agacatgacc tcccaggtaa agattagcca agacgtttaa attttgtgcc
     2461 tttggcagtt actgaagaag tagatgcaac aaggtataga cttccacaaa gggcaacaga
     2521 gaatctgact gatgagtgac agatgaatga agagtctcgg gtttctgttg gctctgtgta
     2581 tgctggtgac tctgactgtg tttacagcca aatgagctct ctggtccctg ctccctgaaa
     2641 tagtcacaac cggtttcaga aaaccagaag gagctgcaag cccactgact tctcttcttt
     2701 ggattggtta catcagaggg ctttggtact actaggacta ccaaaggctc agatggagct
     2761 ctcggacgga gcagaggacc tgtgtgaaaa gtggagctct gacattagtg tcctccacca
     2821 gaccgtgagc aaaatcaaag ggacctggaa acaaaccatc caaactgtca tttccctagt
     2881 attaactgaa aaacaaacaa acaaacaaac aaaaacccta aaaaacaaaa aaaagacaaa
     2941 aacaaaaaca aaaaacaaag ccaacaacaa ctacaacaaa aacccctctc tttcccatta
     3001 ttgtttagtc atctctgttc taaaaatgca ctttttttgc ttctgagcat tatgcttatt
     3061 taattaccca tttccaagcc ttagtaggag tacattgtag tacacacatt tttatgattt
     3121 ttttaaagat ttgtttttat gtttttgctg atttgtttac ttgagacagt cttgacacag
     3181 agcccgagat aacttgaaat cctgatcctc ctgtctccga agcctgagtg ctgagattac
     3241 aggtagctag aagatacgtg cagaggcgtg gagtgaggag ctccagttgc aggcatgtgg
     3301 agctgatcca aggacttgcc agtctccgac cacaagaagg ctacatgtgg ggctgcagag
     3361 agaaaggtat ctacaaacta agactgtcgg aagaggagca atcaaacact ggaaaaagaa
     3421 aaagatactt ttcacaaaga aaggacacta agaagacctt cgtgtattta ctagagaata
     3481 taatttctct tctggagaaa tgggaccact ttcttacctg tttgaataaa ccaaagttat
     3541 gaaccaaatg atcacttttc aaaacagggt gctcttcttg gtctctggtt tgcataaaga
     3601 agaaactgca ggaaatatat atatgtatat atatatatat atatatatat atatatatat
     3661 atatatatat tttgaaagac aaatccatta acccagtgag gtggaagatt ctgctccatt
     3721 tccattcact cctggctagg tggaagcaac ttatttttaa aataagcaat gttacctgat
     3781 tgccaagacg cttctgaagc attttcttac aactccaaat ttgttttttt aaaaaaaata
     3841 aatctgatta acattgagtg gtttctacat ccatgtgcaa attatttatt tattagccag
     3901 caccagatgc atgagctaat tacctctcct gtctctgtgc cttctgtttg cccacagtga
     3961 actcattgtt taaatgcttc aagaacactc aagctgtgtg tttaaaaaaa aaaaaaggat
     4021 tgtattgatt tgtactggta gtttataaaa tttaattaaa acacaagaca tgaatgaaag
     4081 gtggcattgc acagctaata aaatttgtga atttgatttc tttccataa
//
LOCUS       NM_173134               5666 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 2
            (Cdk5rap2), transcript variant 2, mRNA.
ACCESSION   NM_173134 XM_001058949 XM_001059003 XM_001059053
VERSION     NM_173134.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5666)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   2  (bases 1 to 5666)
  AUTHORS   Gao,F.J., Shi,L., Hines,T., Hebbar,S., Neufeld,K.L. and Smith,D.S.
  TITLE     Insulin signaling regulates a functional interaction between
            adenomatous polyposis coli and cytoplasmic dynein
  JOURNAL   Mol Biol Cell 28 (5), 587-599 (2017)
   PUBMED   28057765
REFERENCE   3  (bases 1 to 5666)
  AUTHORS   Park,J.S., Lee,M.K., Kang,S., Jin,Y., Fu,S., Rosales,J.L. and
            Lee,K.Y.
  TITLE     Species-Specific Expression of Full-Length and Alternatively
            Spliced Variant Forms of CDK5RAP2
  JOURNAL   PLoS One 10 (11), e0142577 (2015)
   PUBMED   26550838
  REMARK    GeneRIF: mouse expresses only one form of CDK5RAP2 that is
            equivalent to the human and rat alternatively spliced variant forms
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5666)
  AUTHORS   Mori,Y., Inoue,Y., Tanaka,S., Doda,S., Yamanaka,S., Fukuchi,H. and
            Terada,Y.
  TITLE     Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein,
            Binds to CDK5RAP2 and Regulates Microtubule Stability
  JOURNAL   PLoS One 10 (10), e0140968 (2015)
   PUBMED   26485573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5666)
  AUTHORS   Yigit,G., Brown,K.E., Kayserili,H., Pohl,E., Caliebe,A.,
            Zahnleiter,D., Rosser,E., Bogershausen,N., Uyguner,Z.O.,
            Altunoglu,U., Nurnberg,G., Nurnberg,P., Rauch,A., Li,Y., Thiel,C.T.
            and Wollnik,B.
  TITLE     Mutations in CDK5RAP2 cause Seckel syndrome
  JOURNAL   Mol Genet Genomic Med 3 (5), 467-480 (2015)
   PUBMED   26436113
REFERENCE   6  (bases 1 to 5666)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   7  (bases 1 to 5666)
  AUTHORS   Hassan,M.J., Khurshid,M., Azeem,Z., John,P., Ali,G., Chishti,M.S.
            and Ahmad,W.
  TITLE     Previously described sequence variant in CDK5RAP2 gene in a
            Pakistani family with autosomal recessive primary microcephaly
  JOURNAL   BMC Med Genet 8, 58 (2007)
   PUBMED   17764569
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5666)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 5666)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 5666)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_173134.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000005.1  88975683-88975909   c
            228-295             JAXUCZ010000005.1  88969093-88969160   c
            296-363             JAXUCZ010000005.1  88966558-88966625   c
            364-474             JAXUCZ010000005.1  88946102-88946212   c
            475-551             JAXUCZ010000005.1  88942797-88942873   c
            552-675             JAXUCZ010000005.1  88937564-88937687   c
            676-830             JAXUCZ010000005.1  88934516-88934670   c
            831-993             JAXUCZ010000005.1  88929034-88929196   c
            994-1035            JAXUCZ010000005.1  88927960-88928001   c
            1036-1155           JAXUCZ010000005.1  88927024-88927143   c
            1156-1254           JAXUCZ010000005.1  88924491-88924589   c
            1255-1473           JAXUCZ010000005.1  88919655-88919873   c
            1474-1644           JAXUCZ010000005.1  88901850-88902020   c
            1645-1785           JAXUCZ010000005.1  88897081-88897221   c
            1786-1883           JAXUCZ010000005.1  88888818-88888915   c
            1884-2008           JAXUCZ010000005.1  88883900-88884024   c
            2009-2118           JAXUCZ010000005.1  88882346-88882455   c
            2119-2247           JAXUCZ010000005.1  88880533-88880661   c
            2248-2343           JAXUCZ010000005.1  88873833-88873928   c
            2344-2528           JAXUCZ010000005.1  88871901-88872085   c
            2529-2961           JAXUCZ010000005.1  88863091-88863523   c
            2962-3193           JAXUCZ010000005.1  88858297-88858528   c
            3194-3325           JAXUCZ010000005.1  88855227-88855358   c
            3326-3899           JAXUCZ010000005.1  88849516-88850089   c
            3900-4132           JAXUCZ010000005.1  88847494-88847726   c
            4133-4181           JAXUCZ010000005.1  88840480-88840528   c
            4182-4360           JAXUCZ010000005.1  88837752-88837930   c
            4361-4480           JAXUCZ010000005.1  88833532-88833651   c
            4481-4597           JAXUCZ010000005.1  88830175-88830291   c
            4598-4787           JAXUCZ010000005.1  88827768-88827957   c
            4788-4912           JAXUCZ010000005.1  88826829-88826953   c
            4913-4990           JAXUCZ010000005.1  88823666-88823743   c
            4991-5256           JAXUCZ010000005.1  88822582-88822847   c
            5257-5400           JAXUCZ010000005.1  88819717-88819860   c
            5401-5527           JAXUCZ010000005.1  88812938-88813064   c
            5528-5574           JAXUCZ010000005.1  88807902-88807948   c
            5575-5666           JAXUCZ010000005.1  88807402-88807493   c
FEATURES             Location/Qualifiers
     source          1..5666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..5666
                     /gene="Cdk5rap2"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
     exon            1..227
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="Cdk5rap2"
                     /note="upstream in-frame stop codon"
     CDS             169..5631
                     /gene="Cdk5rap2"
                     /note="isoform 2 is encoded by transcript variant 2; CDK5
                     activator-binding protein C48"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2
                     isoform 2"
                     /protein_id="NP_775157.2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
                     /translation="MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVL
                     PIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKK
                     NIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELL
                     TKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEE
                     KDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEE
                     RQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEVEELN
                     SIIKELTADSTQSREAPLKTQVSEFEVRESENCEAALAEKEALLAKLHSENVTKNTEN
                     HRLLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCE
                     REKAVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYL
                     MTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKTEQNVYAHLAKN
                     LQDTDSKLQAELKRVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQT
                     SYLSICLEEHSQFQLEHFSQEEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQG
                     NDRLESTKQAELMASKADEDTLKFKADDENHFQSDQHLEQSREIMEDYAEGGGKDGYV
                     RHMDSNILDHDGAHTPDTSEDHSLEDELLSLLATFFSKKATPSLESRPDLLKALGALL
                     LERICLAEQGSPGDHSDSKAEKALEQVAVRLRDELGHSCLANSFSKSHSELKSPRGTW
                     LVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPEEAVFSTELESEALGE
                     MPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQLQGQVLELQ
                     KELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEGH
                     ETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSK
                     SQLSVKVSVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAI
                     ITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLES
                     LKQQLVEQEQELQKEQDLNLELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQ
                     IKDSHDICVVCHQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLEKLFL
                     HGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPESPEPSASHALSDDEMSEKSFLSRE
                     PKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGCETD
                     QGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEKLRESLARKTE
                     SLEHLQLEYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQQLL
                     LQKDELLQSLQMELKVYEKLAEEHQKLQQDVNKCPEASDNSFDLFESTQAMAPKSASE
                     TPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKSGHHMLCLIEDYDALYKQI
                     SWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLSSMNTAKLILEKASRLLKL
                     FWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKLQNTAKLLQQSKHQEKIIF
                     DQLVITHQVLRKARGNLELRPRAAHPGTSSPSRPGS"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    580..>1560
                     /gene="Cdk5rap2"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    580..>1560
                     /gene="Cdk5rap2"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    4381..>4923
                     /gene="Cdk5rap2"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; Region: EnvC; COG4942"
                     /db_xref="CDD:443969"
     misc_feature    4381..>4923
                     /gene="Cdk5rap2"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; Region: EnvC; COG4942"
                     /db_xref="CDD:443969"
     exon            228..295
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..363
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..830
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..993
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1035
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1155
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1254
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1473
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1644
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1785
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1883
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2008
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2118
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2247
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2343
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2528
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2961
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3193
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3325
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3899
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4132
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4133..4181
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4360
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4480
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4597
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4787
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4912
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4913..4990
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4991..5256
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5400
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5527
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5528..5574
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5575..5666
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccggga aagatggcgg cggctgcggt ttgaattcca gcggcgccgc ttgactgaga
       61 acaagagctg ggttggaggg ggcgggacct ggggaaccga gcgcgccgcg actgcggggt
      121 aaccagtggc gctgctgctg cagacaccgg tgccacctct ttgtgttcat gatggactca
      181 gggatggaag aggacgtcac cctgcctggg accctcagcg gctgcagtgg ccttcaccct
      241 gttctaccaa gtgatctgga tgtcatcagt gacactactg gcttgggaaa tggagtgctc
      301 ccaatcatgt cagaagaaaa ggtctctccc accagagccc ggaacatgaa ggactttgaa
      361 aaccaaatca ctgagctgaa gaaggagaac ttcaatctaa agctccggat ctacttcctt
      421 gaggagagga tacagcagga gtttgctggc cccacagagc acatctacaa gaagaacatt
      481 gaactcaagg tggaagtgga aagtctgaag cgtgagctcc aggagagaga tcagttgctc
      541 gtcaaagcct ccaaagccgt ggagagccta gcagaagggg gtggttctga aatccagcgg
      601 gtgaaagaag atgcaaggaa gaaggtgcag caggtggaag aactcctaac taaaaggata
      661 catcttctag aagaagatgt gaaagccgcc caagcagaac tggagaaggc ctttgcaggg
      721 acagaaacag agaaggctct tcggctcagc ttagaaagca agctctcggc gatgaagaag
      781 atgcaggagg gggacctgga gatgactctg gctctggaag agaaggacag actgattgag
      841 gagttgaagc tgtctttgaa gagcaaagaa gctttaattc agtgccttaa agaggaaaaa
      901 tctcagatgg catctcctga cgagaacgtg tcatctggag aactccgagg actttctgcc
      961 actctaagag aagaaaaaga gagagacgct gaggaacggc agaaggagag aaaccacttt
     1021 gaagagagga tccaggcact tcaggaggac ctgagagaga aggaaagaga aattgctaca
     1081 gagaagaaaa atagcttaaa gagggataaa gccattcagg gtctaaccat ggcattaaaa
     1141 tcaaaggaaa aagaggttga agaacttaat tccataatca aagaactcac tgctgactcc
     1201 acccaaagta gagaggctcc cttgaaaacc caggtctccg aattcgaggt aagagagtct
     1261 gagaactgtg aggctgcgct ggcagagaag gaagccctgt tggccaagct gcactcggaa
     1321 aatgtcacaa agaatactga gaaccatagg ttgctcagga atgttaaaaa ggtcacccag
     1381 gagttgaatg acctgaagaa ggagaagctg agactagagc gggacctgga ggaagcccac
     1441 cgagaaggga acagaggagc ccgaaccatc catgacctta gaaatgaagt tgagaaacta
     1501 cgcaaggaag tgtgtgagag agagaaggct gtggagaagc attacaagag tcttccaggc
     1561 gaaagcagtt caaagttcca ttctcaagaa caagtggtca aaggtctgac agaaagtgcc
     1621 agtcaggagg acctgctgct gcagaaatcc aatgaaaaag atttggaagc aatacagcag
     1681 aactgttatt taatgactgc agaggagctc aagtttggga gcgatggctt aataacagaa
     1741 aagtgttctc agcagtcacc agacagcaaa ctcatcttct ccaaggaaaa gcaacaatca
     1801 gagtatgaag ggctgactgg ggacttaaag acagaacaga acgtctatgc ccatctggca
     1861 aagaatctgc aggacacaga cagcaaactg caggctgaat tgaaaagggt tcttgccctc
     1921 cggaagcagc tggagcagga tgtgcttgcc tatcggaatc tgcagacggc cctgcaggag
     1981 cagctcagtg aaattcggaa gcgggaagaa gagccgtttt cattttatag cgatcaaaca
     2041 tcatatctaa gtatttgcct tgaagagcac agtcagtttc aattggagca tttttctcaa
     2101 gaagaaatca agaaaaaggt cattgacctc atacagcttg tgaaggacct gcatgcagac
     2161 aaccagcacc tgaagaaaac catttttgat atctcttgca tgggtgtcca gggaaatgac
     2221 agacttgagt caacaaaaca agcagagctt atggctagca aggcggatga ggacacactc
     2281 aaattcaaag cagatgatga gaatcatttc cagagtgacc agcatttgga gcagagtaga
     2341 gagatcatgg aggactatgc tgagggtggc ggcaaggatg gatatgtaag gcacatggat
     2401 tccaatattt tagaccatga tggggcccac acacctgata cctctgaaga ccatagccta
     2461 gaggatgagc tcctgagcct actcgccact ttcttcagta agaaggctac accgtcgctg
     2521 gagtccaggc cggatctgct gaaagcactt ggtgccctgc ttttggaacg gatatgcttg
     2581 gcagaacagg gaagtcctgg agatcactct gatagtaaag ctgagaaggc acttgagcaa
     2641 gtagctgttc ggttgagaga tgaacttggc cattcctgcc tagccaactc attctccaag
     2701 tcacacagtg agctcaagtc accgcggggc acctggctag taaagacagg tgatgaagcc
     2761 aaggtggagc tgaagagtgt ctcagtgcag accatgacca tagaggacag cacccgtgga
     2821 ttcaaacctg agaggaagag agaagcttgg gcagggaaac cagaagaggc cgttttcagc
     2881 actgagcttg agtcagaggc gttgggtgag atgccagggc tacaggccac tcacctctca
     2941 ttccccagtg ccatcgacaa ggatgaccag aagacaggct tgctgatcca attaaaaaca
     3001 cctgagttat tggaaaattt gtataatctt cctgcctccc aagaggtggt agctcaactc
     3061 cagggccagg ttctagagct gcagaaagag ctgaaagagt ataagatccg caacaagcaa
     3121 ctccttgata agctaattct ggcagaggca atgatggagg ggatggcagt gcccaactct
     3181 actccggtaa acgtgcctgc agcccaggct gttgtgagaa cagccttcca aggcaagcca
     3241 ggcgagcaag aaggacatga aaccacacat tctgccggaa gagacaagga agtagacagt
     3301 gaccaatata caagctttga gattgattct gaaatctgcc cacctgatga ccttgcctta
     3361 ttaccagcat gcaaagagaa ccttgaagac ttcttaggcc caccctccat agccacttac
     3421 ctggattcca agagtcagct ctctgttaaa gtcagtgtgg ttggaactga ccagtctgag
     3481 aatatcaatc tccctgatga tacagaagcc ttaaaacaga aaatccatga cttgcaaact
     3541 gagctggaag gctaccggaa catcattgtc cagctacaga agcattctca gtgcagtgag
     3601 gctattatta cagttttgtg tgggacagaa ggggcccaag atggcctgaa caagcctaag
     3661 ggccacatcg atgaagaaga gatgacattt tcaagtttgc accaagtaag atatgtgaag
     3721 cacatgaaaa tcctccgtcc actaacccca gaaataattg atggcaagat gctagagagc
     3781 ctcaagcagc agctggtaga acaggagcag gagctacaga aggagcagga tttgaacttg
     3841 gaacttttcg gtgaaatcca taacctgcag aacaagttcc gagacctctc gccatcaaga
     3901 tacgattcat tggttcagtc ccaagcaagg gagctctctc ttcagcggca gcaaattaag
     3961 gatagtcatg atatctgtgt cgtttgccat caacacatga gcaccatgat caaggcattt
     4021 gaggaacttc tgcaggccag tgatgtggac agttgtgtgg ctgagggctt ccgcgagcag
     4081 ctaacacagt gtgctggact gctagagcaa ctggagaagc tgtttctcca tggaaagtca
     4141 gccagagtgg aaccacatac ccagactgaa ctgctaagga ggttaagaac tgaagaagac
     4201 aacttacctt accaacatct cctgcctgaa tctcctgagc cttctgcctc tcatgctctg
     4261 tcagatgatg aaatgtctga gaagtccttc ctgtccagag aaccgaagcc agacagtgag
     4321 actgagaagt acccaacaat agcgagccgt tttcctcaag acttactaat ggaacacata
     4381 caggaaattc gaactttgag aaagcatttg gaagaatcta ttaaaacaaa tgagaagctc
     4441 cggaaacagc tggaacggca gggatgtgag actgaccaag gctctacaaa tgtttctgct
     4501 tacagctcag aactgcataa ttctctgaca tcagaaatac agttcctgag gaagcagaat
     4561 gaggccctca gtacgatgct cgagaagggg tccaaagaaa aacagaaaga gaatgaaaaa
     4621 ttgcgtgagt ccctggccag gaagactgag agtcttgagc accttcagct agagtatgcc
     4681 agtgtaaggg aagaaaatga aagactgcgg agagacatca gtgagaagga gagacaaaac
     4741 cagcagttga ctcaggaggt ctgcagcagc ctccaagagc tgagcagggt acaggaagag
     4801 gcaaagtcaa gacagcagct gctcttacag aaagacgagc tgcttcagtc cctccaaatg
     4861 gagcttaagg tgtatgagaa gctggccgag gagcatcaga agctacagca agatgtcaac
     4921 aaatgtcctg aggccagcga taattcattt gatctatttg aatctaccca ggcaatggca
     4981 cctaaatcag cttctgagac tcctgtcctt tctggaactg atgttgattc cctctcctgt
     5041 gacagtacca gttctgccac cagcccctct tgcatgccct gcctggttgc tggccgccac
     5101 ctgtgggcca gcaagagtgg ccaccacatg ctgtgcctga ttgaggacta tgatgccctc
     5161 tataagcaga tcagctgggg ccagacactg cttgccaaga tggatattca aacccaagag
     5221 gctctgagcc ccacaagtca gaagctggga ccaaaggctt cattctctgt gcctctgagc
     5281 aagtttctct ccagcatgaa cacagccaag ctgatcctgg aaaaagcctc caggttgctg
     5341 aagctcttct ggagggtctc tgtccccacc aacggccagt gttcccttca ctgtgaccag
     5401 attggagaaa tgaaggcaga gatcaccaaa ctacacaaaa aattgtttga acaagaaaag
     5461 aagctgcaga acacagcaaa acttctgcag cagagcaagc accaggagaa aatcatcttt
     5521 gatcagttgg tcatcaccca ccaagtcctt cggaaagcca ggggaaacct ggagctcagg
     5581 cctagagctg cccatccagg aacatccagt cccagcagac cgggctcatg agaagagctt
     5641 tcagctaata aagcttgtga tcctga
//
LOCUS       NM_001436654            5183 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 7 (Slc26a7),
            transcript variant 2, mRNA.
ACCESSION   NM_001436654 XM_006237911
VERSION     NM_001436654.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Kiriya,M., Kawashima,A., Fujiwara,Y., Tanimura,Y., Yoshihara,A.,
            Nakamura,Y., Tanigawa,K., Kondo,T. and Suzuki,K.
  TITLE     Thyroglobulin regulates the expression and localization of the
            novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes
  JOURNAL   Endocr J 69 (10), 1217-1225 (2022)
   PUBMED   35644541
  REMARK    GeneRIF: Thyroglobulin regulates the expression and localization of
            the novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes.
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            acid challenge represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Kosiek,O., Busque,S.M., Foller,M., Shcheynikov,N., Kirchhoff,P.,
            Bleich,M., Muallem,S. and Geibel,J.P.
  TITLE     SLC26A7 can function as a chloride-loading mechanism in parietal
            cells
  JOURNAL   Pflugers Arch 454 (6), 989-998 (2007)
   PUBMED   17404755
  REMARK    GeneRIF: SLC26A7 is a Cl(-) uptake system under histamine
            stimulation
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   Petrovic,S., Amlal,H., Sun,X., Karet,F., Barone,S. and Soleimani,M.
  TITLE     Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7
            in kidney medullary collecting ducts of Brattleboro rats
  JOURNAL   Am J Physiol Renal Physiol 290 (5), F1194-F1201 (2006)
   PUBMED   16352747
  REMARK    GeneRIF: vasopressin increases the expression of SLC26A7 protein
            through posttranscriptional mechanisms in the outer medullary
            collecting duct
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237911.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12743.1,
                                           SRR26643298.26547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000005.1  32818836-32818928   c
            94-406              JAXUCZ010000005.1  32818355-32818667   c
            407-517             JAXUCZ010000005.1  32786927-32787037   c
            518-690             JAXUCZ010000005.1  32780136-32780308   c
            691-855             JAXUCZ010000005.1  32757312-32757476   c
            856-1008            JAXUCZ010000005.1  32743404-32743556   c
            1009-1091           JAXUCZ010000005.1  32734765-32734847   c
            1092-1239           JAXUCZ010000005.1  32732596-32732743   c
            1240-1353           JAXUCZ010000005.1  32730466-32730579   c
            1354-1431           JAXUCZ010000005.1  32721568-32721645   c
            1432-1527           JAXUCZ010000005.1  32720536-32720631   c
            1528-1634           JAXUCZ010000005.1  32712705-32712811   c
            1635-1701           JAXUCZ010000005.1  32704950-32705016   c
            1702-1839           JAXUCZ010000005.1  32701574-32701711   c
            1840-1888           JAXUCZ010000005.1  32698486-32698534   c
            1889-1989           JAXUCZ010000005.1  32689483-32689583   c
            1990-2044           JAXUCZ010000005.1  32685795-32685849   c
            2045-2148           JAXUCZ010000005.1  32685608-32685711   c
            2149-5183           JAXUCZ010000005.1  32681653-32684687   c
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5183
                     /gene="Slc26a7"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
     exon            1..93
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            94..406
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Slc26a7"
                     /note="upstream in-frame stop codon"
     CDS             214..2184
                     /gene="Slc26a7"
                     /note="isoform a is encoded by transcript variant 2; anion
                     exchange transporter; solute carrier family 26 (anion
                     exchanger), member 7"
                     /codon_start=1
                     /product="anion exchange transporter isoform a"
                     /protein_id="NP_001423583.1"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
                     /translation="MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLK
                     ENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG
                     TFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQL
                     VMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAY
                     VFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCT
                     NMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKF
                     KYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLI
                     VIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTIC
                     FAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKIISIN
                     NPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCP
                     SEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLD
                     TEKPIFFDSVATAISVIQSNKNLSKDTDHSEV"
     misc_feature    310..2124
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    310..2124
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     exon            407..517
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            518..690
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            691..855
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1008
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1091
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1239
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1353
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1431
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1527
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1634
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1701
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1839
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1888
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1989
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2044
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2148
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..5183
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaccatct caccgccgaa cccattcctt ttccaagatc agaaaagtag tacatgaaca
       61 gggacccatt tcttattgag ataagaactc aagctttgac attgtaaacc acagacggat
      121 tggagcctgg catcgaaagg aggtgttctc caacgatttt tttctctctc ccttgcctga
      181 aaaagttgac tactacagga gggaatctga gaaatgacgg gggcaaagag gaaaaagaga
      241 agcgtgctgt ggggcaagat gcacaccccc caccgagaag acattaaaca gtggtgtaag
      301 aggcgcctac ctatcttgga atgggcaccg cagtacaatc tgaaggaaaa cctgcttcca
      361 gacaccgtgt ctggcgtact gttggcagtt caacaggtga cacaagggct gtccttcgct
      421 attctttcat ctgtacaccc agtttttggt ttatacggat ctctgtttcc tgccatcatt
      481 tatgcgatat ttggaatggg acgccatgtt gccacaggca cctttgcctt gacgtccttg
      541 atatcagcca atgctgtgga acggctggtc cctcagagca atagaaacct caccacacag
      601 agcaactcaa gcgtgctggg cttatcggag tttgagctgc agagaatcgg ggttgcagca
      661 gccgtttcat tcttgggcgg agtgattcag ctggtcatgt ttgtgctgca gctaggcaat
      721 gccacattcc tgcttacgga gccagtgatc agtgccatga ccaccggcgc tgccacccat
      781 gttgtgacgt cacaagtcaa gtatctcttg ggaataaaaa tgccatatat atctggacca
      841 ctgggattct tttatatcta tgcgtatgtt tttgagaaca tcaagtctgt ccagctggaa
      901 gcactgctct tgtccttgct gagcattgtt gtccttgtcc tcgttaaaga gctgaacgag
      961 cagtttaaga gaaagattaa agttgttctt cctgtcgact tagttttgat cattgctgcc
     1021 tcatttgctt gctattgtac caacatggaa aacacatacg gattagaagt agttgggcgc
     1081 attccaaaag ggatccctcc gccccgtgct cccccaatga acatcctctc cgcagtgctc
     1141 acggaagctt tcggagttgc acttgtaggc tacgtggcct cgctggctct cgcacaagga
     1201 tctgccaaga agttcaaata ttcagttgat gacaaccagg aatttttggc ccatggcctc
     1261 agcaacgtga ttccttcatt tctcttctgc atcccaagcg ccgccgccat gggaaggaca
     1321 gctggtctgt acagcacggg ggcaaagaca caggtggctt gtctaatatc ttgcattttc
     1381 gtccttatag tcatctatgc aataggaccc ttgctgtact ggctgcccat gtgcgttctt
     1441 gcaagtatta ttgttgtggg actgaaagga atgttaatac agttccggga tttaaaaaaa
     1501 tactggaatg tggataaaat cgattggggc atatggatca gcacttacat ttttacaata
     1561 tgcttcgctg ccaacgtggg actgctcttt ggtgttgtct gcaccatagc tatcgtgtta
     1621 gggcgtttcc caagggcaaa gactttaagc ataacagaca tgaaagaaat ggaattgaag
     1681 gtgaagacag aaacgtatga tgaaaactcg caacagataa aaatcatctc aataaacaac
     1741 ccacttgttt tcctgaatgc aaagaaattt agtgctgatc ttatgaaaat aatcctaaag
     1801 gaaactgacg gcagccaagc acttgatgat gtcagcaagt gtgaacagaa caccttgctc
     1861 agtcccctgc ccaacgggag ctgcactgaa gaagcctccc agccctgccc cagtgagaag
     1921 tattctttgg tcctgaattg cagtggcttg acctttttcg actacacagg agtctccaca
     1981 cttgttgagc tctaccttga ttgcaagagc aggagtgtgg atgtgttctt agccaactgt
     2041 acagcatcct tgataaaagc gatgacatac tatggagacc tagacactga aaaaccaatt
     2101 ttttttgact cggtagccac tgcaataagt gtcatccaat caaataagaa tttgagcaag
     2161 gacactgacc acagtgaagt ctgaggtcca cgcattgaaa tgcacatctc atctttagca
     2221 cctgccccaa agaggccaga tactggcatt ttgcactcat tttggtgtat atactgtata
     2281 tctcttaatt agaatgatgt gagttggcaa ctggatagcc actggccaag acttgctgac
     2341 atcctatttt ttctaatttt tcttaataaa cagattcatt agttatttca tataggcatc
     2401 aatatgcatg tagctttagt ttaatgaaca gtaaacatgc ttttatttcc agttataaga
     2461 gtattttgta tggtttcatt tttgttgtaa gctaacaaat ggagaaatat ttttatcaga
     2521 aatggtttgg attatttata aaccattcat aaaaaaatta agatcatcta gtacataaaa
     2581 aagtattaac aaatgtgcca tttctccata gtttttatcc caaaattatt tgaacatcag
     2641 ttagataaag tatcactttt atacagggaa aatgaaatcc atagatataa aacaagtgag
     2701 aaagagacaa attagaagtt attaatgtca atgcccatca acacactcac tctgacaata
     2761 ttcatatatt caattatgag ttcatatttg gaagaaaact aatgttttag caaaactaag
     2821 ttcttgatgt ttatctgctg aattgtggat actggagacc atttgtgtgt ttaatcagat
     2881 aactctgact tctgcattgc aacacataag atattctgct ttcaaacttc tttcttgcaa
     2941 tcagagaata tgagaatttg atatgtattt tttcaaaaat atgcattttt caatgataaa
     3001 atatcataag tagaatgctt ttgtgctttt ggatacaaga ttaaccctta gaaattttga
     3061 attttctatt tgagatataa aaagtcaaca aaatataata tgttattgat ctataccaag
     3121 atagatagat tgaagataga acgacagaca gacagacaga agacaggtag acaacagaca
     3181 gatgacagac agatctccaa ggtatgtttt ccattttctt ttgttagaga tgagcttgaa
     3241 tgtgattata cgtaaatttg ctaatacaat aggataattt ataacactaa tggccagata
     3301 taagtgtaaa catttttcat acttgtatat tttattttta tctatataca agaatgaaat
     3361 ttcacaattt tttaaacaaa ttgtcttata tatgaagcca cagattaaat tatgatttat
     3421 ccttaatagc atctaaaaca ttctacaaag ttagtaacgc tgtcagaaaa aaaaaaaaca
     3481 aaacacaaaa aaaaaaaaaa cagcaaaggg agtttgaaaa gcaagttaaa aattggcctt
     3541 ctggtgtggt tcttatgggc atctgtaaga gcaaattcta actcctgtcc aaatgacaga
     3601 gtggaatagt ccttcgccag tgcaaggtaa acatttacac aatccactgt tttaacacct
     3661 cactctttgg caggatgaaa taataagtga aaactaaaaa tagcgctcta aattttcatg
     3721 gtcattttca atttttactg aaacaaattc aaaagtcttg ttcccccaaa ttgccccaat
     3781 ttcttcatca cttattgggg tagtaccaag taaggtgacc agtattgctc atcagatagg
     3841 tttctaaggg aagtctgagg gagaattaga aaggagtttt attctgcgtc atccacttcc
     3901 cttactctat acgtgcagag tggtggactc taccttgtaa tcaggagtca tgcgaagcca
     3961 agaaaagaaa tagattatgg tgcatagaaa gtgatatttt gctatacaaa tttgacctta
     4021 attaaattca tgagttgtag gcatttttaa tttgttgtag atgatgggcc ttgggtgaca
     4081 ttaaagtcat tatagctatt tgttggatag tttttctgtt tcgttgtgaa tgctcagaca
     4141 gtattgtctg agaaactgca tctgagtgca tttaagtata agcttaatgc ataaaaagtc
     4201 aaccccatca atttcagtat caaacattgt tacagccaaa acaagaaaga caagaccaca
     4261 cactgtataa agtccactgc tctatagttt atgccaagac cacaatcttt ttaacccaaa
     4321 gaaagtctct taattaaggt ccaaggctcc aagaactgca cataagtttt agacatacaa
     4381 gtgtttattt caaagcagac tcagagagca gagaagctac aacatggctc tagtgttgta
     4441 atattttcta tcagcacact gacctattct gagggggcca tgttaatttt atatgataaa
     4501 ctccttccgt agtacttatt atagtaaaat aacatagaaa actgacctat acgagtgtta
     4561 agaacctaat atggcagata tgaaatatgt aaccaggaaa aactgttaac attaaacatc
     4621 acatttatgc aaattaaatg cccttaaaat tttgccattc gtctttcatt tttaaaggtt
     4681 atttgccctc aattatgtaa tttcagtgtt ataaagttta gcttaaacta ctttgcaata
     4741 atttatttga cagatctccg ttctataaac catgcaatgt aatgaggcca gagatctttc
     4801 ttttttaatg aaaacattaa catgttaata tcccacatga atgatgcttg acattcaacg
     4861 attgtcgaaa tatgttggta tgttgctgaa catacacaca cctctgaaat gccagttctg
     4921 cgttctgtgg gctgatgatc tgactcatcg tgtgacatat gctttctggc agtgagttca
     4981 ttgccagagt ttaaacaggg agttacggtg ctcatggcgc tttcagaacc caaagatttg
     5041 tggtttggaa tcatgtagtc tagtatgctg cacttatttt tatattttta atgcacttaa
     5101 ttattgtttt tacaattatt tgtactaact cagcatgtaa caaccaattt acatggaaat
     5161 aaattgaaat atgataacta caa
//
LOCUS       NM_001436613            2730 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 2, mRNA.
ACCESSION   NM_001436613 XM_063275648
VERSION     NM_001436613.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2730)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2730)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2730)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063275648.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.75509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000016.1  73925338-73925527
            191-341             JAXUCZ010000016.1  73925721-73925871
            342-421             JAXUCZ010000016.1  73926790-73926869
            422-477             JAXUCZ010000016.1  73927485-73927540
            478-556             JAXUCZ010000016.1  73929777-73929855
            557-633             JAXUCZ010000016.1  73930126-73930202
            634-811             JAXUCZ010000016.1  73931687-73931864
            812-877             JAXUCZ010000016.1  73932826-73932891
            878-949             JAXUCZ010000016.1  73934031-73934102
            950-1107            JAXUCZ010000016.1  73934279-73934436
            1108-1189           JAXUCZ010000016.1  73935273-73935354
            1190-1326           JAXUCZ010000016.1  73939574-73939710
            1327-1516           JAXUCZ010000016.1  73941664-73941853
            1517-1612           JAXUCZ010000016.1  73946164-73946259
            1613-1808           JAXUCZ010000016.1  73947426-73947621
            1809-1899           JAXUCZ010000016.1  73957828-73957918
            1900-2116           JAXUCZ010000016.1  73958685-73958901
            2117-2203           JAXUCZ010000016.1  73973622-73973708
            2204-2318           JAXUCZ010000016.1  73974416-73974530
            2319-2481           JAXUCZ010000016.1  73981312-73981474
            2482-2535           JAXUCZ010000016.1  73983410-73983463
            2536-2730           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2730
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..190
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    173..175
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="upstream in-frame stop codon"
     exon            191..341
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..2548
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; a disintegrin and metalloprotease domain (ADAM)
                     5; tMDC II; a disintegrin and metalloprotease domain 5;
                     disintegrin and metalloproteinase domain-containing
                     protein 5; transmembrane metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein II; a
                     disintegrin and metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 1 precursor"
                     /protein_id="NP_001423542.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MFLLLLLVVHLNGLQAGQHPQKTILQTTVPEKISSPDVETDPEN
                     HMAYLITINENPHFIHLKKQSFITSTAVSYTYDRQDVRHSQSLSSLKNCNYNGYVAGF
                     PNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTY
                     SWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGF
                     INTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFV
                     EHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCH
                     CTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRI
                     CGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLC
                     RKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKY
                     VRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQ
                     IRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLV
                     DFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSA
                     KQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVS
                     NTKMTTNEGSTLH"
     sig_peptide     287..334
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    362..712
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    362..712
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    839..1420
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    839..1420
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1481..1705
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1481..1705
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1715..2146
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1715..2146
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            342..421
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            422..477
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            478..556
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            557..633
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            634..811
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            812..877
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            878..949
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1107
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1189
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1326
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1516
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1612
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1808
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1899
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2116
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2203
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2318
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2481
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2535
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2730
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaatgctt tgaaggtctg tgtttgacca atgagtattt aggggatgtc ccgcatgcag
       61 ctgtgaaaac aacaaaccag gttagcaaca ttgttgttgt tgttgttgtt gttgttctcc
      121 gttgttggga cagtttgccc aagtatcctg gaagacgtgt ggctgccatc agtaacctga
      181 acattttcat gttcagctgc gggagcttcc gttactggcc acaacgccct ccccacctgc
      241 ctggccagat gctcctcagc taagctccag gaccaccaag ggagccatgt tcctccttct
      301 tttgctggtt gtgcatctta atgggctgca ggcaggccaa catcctcaga aaaccatcct
      361 gcaaacaact gttcctgaaa agatctcatc accagatgtg gaaacagatc cagaaaacca
      421 tatggcttat cttattacaa taaatgaaaa cccccatttc atccatctta aaaagcaatc
      481 gtttataact tcaactgcag tgagttatac atatgacaga caagatgttc ggcattctca
      541 gtctttgtca tctctgaaaa attgcaatta caacggatac gttgcaggtt ttccaaattc
      601 tatcgtgtcg ctcaccgttt gctcaggact caggggaatg atacaatttg aaaatgtctc
      661 ctatggaatc gaacctgtgg aaaccctgtc aggatttata cacgtgatct atgagaacac
      721 aaatcagcaa gctaagattc ctgacttagg agagaatcag acgtacagtt ggtctgatga
      781 attagattat caattccgaa gcaacatgaa gaaatccgga tttgccgtgt tacggccacg
      841 gtacattaag acggatatcg tcgtggataa aaagctgttt gattacatgg gctccgacac
      901 tagggtcgtg ctacagaaag tcattcagat catcggtttc attaacacta tgttctccaa
      961 gttgaaactg acggttttaa taaattccgt tgaaatctgg tcgaaggaaa acagaattga
     1021 tttcccagag gcacctgaaa acttactggt ccagttttta cattggaaac ataagtatag
     1081 accgcagcac atttcatact tactggcatt tgtggagcat cctgcttcca cgggagccct
     1141 ctatccgggg aatctgtgca aaccgatcta tggtgctgcc attgccctgt accctaaagg
     1201 tttgtcacta gagtcctaca gcgtcatcgt cctacaacta ctgagcatcg gtataggctt
     1261 aacctatgac aacgctgaca gctgccactg tacaggagac gtctgcctga tgacgcccaa
     1321 ggcaatatat tctgggggtg tgaaggactt cagtacttgt agcttggatg acttcaaata
     1381 cctgtcaaca caagaccttg aatgtctcca ggacttgcct atggaaagac aaaagaagaa
     1441 gccttccagg ccaaggagaa tctgtggcaa cgggatattg gaaatgaacg agcagtgtga
     1501 ctgtggcact ttgaagaatt gtacacacaa aaaatgctgt gaccccatgt cgtgccgact
     1561 gaagtccaaa gccgtgtgtg gctccgggga gtgctgtggt caggactgca aggtaaaacc
     1621 ggttaatgta ctctgtagaa agtcgaagaa tgaatgtgac tttgaggagt actgtaacgg
     1681 aaatgacgct tactgtgtcc ctgacacgtt cgcacgcaac gggcagtact gcgactcagg
     1741 gcaagccttc tgctacagtg gtctttgtat gacgagtaat aatcaatgca tgaacttgct
     1801 cgggaaatat gtgagaggag cttccttcgc atgctatgaa gagttcaatt ccagaaacga
     1861 tagatttggc aactgtatta gaaagttttg tagtttcgaa aattctctct gtgggaagtt
     1921 ggtctgtacc tggccattca agaggctgct catgaaagac aatatgtctg cggcttatgg
     1981 acaaatccga gacgatttat gcatctctct gtataaagga gggaggccac ttaagacaac
     2041 attgtcaaca tattccgata tgtcagaaag agacgaaaca tttgtaaaag acggcacaat
     2101 ctgtggtcct gatatgtttt gtttggaaac acagtgcaaa gaaacgagat ttttggtgga
     2161 ttttcaacag tgcaatactt cccgagattg caatgaccat ggggtttgca acaactttaa
     2221 tcattgtcat tgtgataaag gatataaccc tccctattgt gagtcagtaa aaggacagtt
     2281 tggaagcatt gatgacggcc acaaatatta cattgacgaa gggaaaagcg ctaagcagca
     2341 gaatcgtggt attcacccaa agcagcaact ccagcttatt ctgtatataa cgctgccctt
     2401 gattatgatt atctcggctg tatttataaa gcaaagcaaa ctgagtcggc tatgcggcag
     2461 agaaagaagc gaaggcacca gctgtataac agaagacagt gtgagtaaca ccaagatgac
     2521 caccaacgaa ggaagcaccc ttcactaacc acctcaagtg ttgccaccca aaaagaagat
     2581 agtctggatt aaccacggga aactggcatt ttgagcaaga ggaaggggaa aaaaccaccc
     2641 ccaaaccaac ccacagcttc tctcccactt ctgcagagat aaatgaggac tctaaaccat
     2701 gaactaataa atcagcggtg gctgaacaaa
//
LOCUS       NM_001436629            4435 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus DDHD domain containing 2 (Ddhd2), transcript
            variant 3, mRNA.
ACCESSION   NM_001436629
VERSION     NM_001436629.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4435)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (bases 1 to 4435)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (bases 1 to 4435)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (bases 1 to 4435)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71943.1,
                                           SRR26360172.501296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000016.1  73022193-73022329
            138-363             JAXUCZ010000016.1  73023386-73023611
            364-554             JAXUCZ010000016.1  73024257-73024447
            555-644             JAXUCZ010000016.1  73025595-73025684
            645-765             JAXUCZ010000016.1  73026637-73026757
            766-855             JAXUCZ010000016.1  73027465-73027554
            856-991             JAXUCZ010000016.1  73029229-73029364
            992-1200            JAXUCZ010000016.1  73033702-73033910
            1201-1268           JAXUCZ010000016.1  73034155-73034222
            1269-1391           JAXUCZ010000016.1  73035946-73036068
            1392-1487           JAXUCZ010000016.1  73036977-73037072
            1488-1571           JAXUCZ010000016.1  73038456-73038539
            1572-1727           JAXUCZ010000016.1  73038642-73038797
            1728-1830           JAXUCZ010000016.1  73039438-73039540
            1831-2001           JAXUCZ010000016.1  73039664-73039834
            2002-2161           JAXUCZ010000016.1  73041377-73041536
            2162-4435           JAXUCZ010000016.1  73049473-73051746
FEATURES             Location/Qualifiers
     source          1..4435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4435
                     /gene="Ddhd2"
                     /note="DDHD domain containing 2"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
     exon            1..137
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..363
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2243
                     /gene="Ddhd2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     phospholipase DDHD2"
                     /codon_start=1
                     /product="phospholipase DDHD2 isoform 1"
                     /protein_id="NP_001423558.1"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
                     /translation="MSSGESYQEQLSQSDPSPSPNSSSSFELLDMDVGSSYEPVSPHW
                     FYCKVIDSKELWIPFNSEDSQQLEEAHGSGKDCNERVVPTDGGRYDVHLGERMRYAVY
                     WDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKLESPNREI
                     IVLHNPKLMVHYQPITGSDEWGSTSTEQGRPRSVKRGVESIPVDIHCGEPLQIDHLVF
                     VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPL
                     HSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLF
                     LQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSIGDIDSEKGSLSTAEDLGDVSTLEE
                     ELKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSATKSSVGI
                     NRPTMSASEVNIPKEKGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLR
                     RIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELRE
                     GLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASEMAEDTEAESEPSSEKPSDANTE
                     EPPVEVKEEAPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLV
                     LKEIYQTQGIFLDQPLQ"
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1593..2204
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    1593..2204
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     exon            364..554
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..644
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..765
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..855
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..991
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1200
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1268
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1391
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1487
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1571
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1727
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1830
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2001
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2161
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..4435
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctcagg ccctgaaccg ggtgagcgga ctccgcaggg ctcactgctc gcggctggat
       61 cgctgaggag cccgtggtgc gggattgggg cgcggccaca ggctccgccc gtctgcccgc
      121 cccgcccggc ttgggagagc gaaatgtcat caggggaatc gtaccaggag cagctgtcac
      181 agtcagatcc atccccctcc ccaaactcca gtagttcctt cgagctgcta gacatggatg
      241 ttggcagttc ctacgaaccc gtttctccac attggtttta ttgtaaggta atagactcta
      301 aggaactctg gattcctttc aactctgaag attcacagca gctggaagaa gcacatggct
      361 ctggaaagga ttgtaatgag agagttgtcc ccactgatgg gggcagatat gatgtccatc
      421 tcggggagag gatgcggtat gccgtgtact gggatgaact accatcagaa gtgagacggt
      481 gcacgtggtt ttacaaggga gacaaagaca ataagtacgt cccctactcc gagagcttca
      541 gccaagtttt ggaggataca tatatgcttg cggtaactct ggatgaatgg aaaaaaaaac
      601 tagagtctcc aaacagagaa attattgtat tacacaaccc aaagctcatg gtgcattacc
      661 agccaatcac agggtctgat gaatggggtt caacatccac tgagcaaggt cggccaagat
      721 cagtaaaaag aggcgttgag agcatccctg ttgatattca ctgtggggaa cctttacaaa
      781 tagatcactt agtgtttgta gtccatggga ttggaccagc ttgtgatctc cgttttcgaa
      841 gcattgttca atgtgttaat gattttcgaa gtgtttcctt gaacctgcta caaacacatt
      901 ttaagaaagc ccaagaaaac cagcagattg gaagggtaga gttccttccg gtcaactggc
      961 acagcccttt gcattctact ggagtagata tagatctgca gcggataacc ctacccagca
     1021 tcaatcgcct tagacacttc actaacgata caattctgga tgtcttcttc tacaatagcc
     1081 ccacctactg tcagactatt gtggacacag tagcttctga aatgaaccga atatatacac
     1141 tttttctgca gaggaaccct gatttcaaag ggggtgtatc cattgctggt catagtttag
     1201 gttcgcttat attgtttgat atcctaacaa atcagaaaga ttctattggg gatattgaca
     1261 gtgaaaaggg ttcattgagt actgctgagg atctaggaga tgtatcaaca ttagaagaag
     1321 aactgaagaa gcttcagctc tctgagtttg tcactgtctt tgagaaggag aaagttgaca
     1381 gagaagctct ggctttatgt acagacagag atcttcagga aatggggatt cccttaggac
     1441 ccagaaagaa gatactgaac cacttcagtg ccacaaagag ttcagtgggt attaatagac
     1501 caaccatgtc agcttctgag gtaaatatcc ccaaggaaaa aggtgactat ttggatgttg
     1561 gaattgggca ggtgtctgta aaataccccc ggcttaacta caaaccagaa atattctttg
     1621 cctttggatc tcccattgga atgtttctta ctgtccgagg attaagaaga attgatccaa
     1681 attataaatt tcccacatgc aaaggtttct tcaatattta ccatcctttt gatcctgtgg
     1741 catataggat tgaaccaatg gtggtcccag gagtagaatt tgagccaatg ctgattccac
     1801 atcataaagg caggaagcgg atgcacttag aactgagaga gggcttgacc aggatgagta
     1861 tggacctgaa gaacaacttg ctgggttcac tgaggatggc ctggaagtct ttcaccagag
     1921 ctccataccc tgccttacaa gcttcagaaa tggcagaaga cactgaggca gaatccgaac
     1981 caagttcaga aaagcccagt gacgccaaca cagaagagcc tcctgtggag gtcaaagagg
     2041 aggctcccat caatgtggga atgctgaatg gaggccagcg cattgactat gtgttacagg
     2101 agaagcccat tgagagtttt aatgaatatt tatttgctct acaaagccat ctatgctact
     2161 gggaatctga agatacagta ctgcttgtcc tcaaagagat ctaccaaacc caggggatct
     2221 tccttgatca gcctttacag taaaatgacc catctgtggc tgcttaatgt gagtttttaa
     2281 tgcaatgaag tgtgtatacg tgaacatgtt ataaggaaca ttggagcctc aagctctcga
     2341 tgtagatctg cctacatcct cacaatctag gtaacactca ctgtagggca ctggttaaaa
     2401 ttcataggaa gcgtccagta gttcactcag aaaaggttcg gtgcgtatct taccttgtgc
     2461 ttaggatccc aagtcaccac actgggcctc cagtcaggaa cctggaaagt ctgtatgaga
     2521 ctggcattct ctgtggtggc tggttcccct ggctggccac cctgaccttc tcccactctc
     2581 tcctgtagat ggacattgag ggagcctttc ctgaaaaccc cctcacttgt tgctgcagct
     2641 ttcttctcag ctaccgtgtg tcctgcatgt tgcctgcctt actccacggg atctttcaag
     2701 ataaccctct ttggaaacta ggtgaaagca gagggaagac tgcctcatat gaactctcgc
     2761 catttttgta gctagggact tccatattta atgctttagc agcagcccct ccttggttat
     2821 tacatggaaa tggatagtct gttaaggggg cttagagagc tttatgtcct ctccttagaa
     2881 agtgggcccg ttggggagct tatgaagatg gagaggactt aggggtccag tcgcactgga
     2941 gggctaagca tgtgtggatg tgggatagct gctaggtttt gagccagcat ttatttcttt
     3001 gctgtgtgtg aaaaccagag gctgccctga gcactcacat ggcactgtag ggaccactgg
     3061 ggctgtttgt ggttgttata gttgcctcag cgtctgtaac cccagaggct gtatgggctg
     3121 tgtgcctgcc cttctacacc atactccaaa ccagggtgaa gtgcagggag tgaggtggta
     3181 atacttactt gaaggtcacc ctgaagttac atggtccttc tcagctgttc atgtagaaaa
     3241 tgtggttttt tagtagcacg gacttgtcac ctgcttcttc acttgagaaa aggaagtatt
     3301 gtgacataaa cgtcactgct ttctgaggta tcatcaaaat gtttacttat agttggcagt
     3361 cagtgtagtt gagcatgcag gttaggcaag ggggaagacc acattctgaa agaaaatcct
     3421 gtctacaggg tctgaggagc agctgtatac actgtgcagt ggcagctgaa tctgcagaat
     3481 tcaaagcacg tttatcctga ggaagaatga ctgtatactg tcttcccctt cctcagcatg
     3541 tgctgtcgtc cgtcctcttc atgattgtcc tttattctcc ttagttagct cctccgattt
     3601 ccacaggtct ctttataggt gagctgtggt ttgatttttg accttttttt gtaaactgat
     3661 catggtatcc agaggcactg cacataacac gccctgaagc ccctcagatg gtggtgccct
     3721 tgacacaccg ggagagggag gcgagcactg tgccctggag gtcagaggca caggacagtc
     3781 aggcctggcc ttcctttctg cttatgggta atactggata agcaagctac tgaggagttc
     3841 caggtatatg gaatatttta ttttttctac agtatgtctt gagtaagaat atctgagaat
     3901 gaagtagtat tcattaaata ctagagtaat tttgtcaatt gttgtcttga gatttgttta
     3961 ctcttgttag cagtcattac tatgttaaga gtaaaccaaa gcacaactga gtgtgttctt
     4021 gtgaccaaag atgggcagct tggccctgga gagctagata aaccactgca ctaagaaatg
     4081 ctgcttcccg gcagtccagt acagtaactc aaagagcttg cacctcacca tccactcgtg
     4141 gcgttatcac gctcagtatt acacaagtga gtagggcaag gggcctgggt acgggtgtgc
     4201 attgcgtcat ttgttaccat gtacagtttc ttgaccaagg ctgtttttaa actccagtgt
     4261 aacagcattt tgtacgtaat tctggctaca caattcgtga gagactgttt gcaagggatg
     4321 aacagcactg attaccttcc tgatattttg cacttttgaa atgttttgtt ttatatgtga
     4381 ttatatttaa gactttagta aatgctgaaa taaaactatt gaccatttac ctaca
//
LOCUS       NM_031974               1140 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus clathrin, light chain A (Clta), transcript
            variant 2, mRNA.
ACCESSION   NM_031974
VERSION     NM_031974.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Li,H., Alavian,K.N., Lazrove,E., Mehta,N., Jones,A., Zhang,P.,
            Licznerski,P., Graham,M., Uo,T., Guo,J., Rahner,C., Duman,R.S.,
            Morrison,R.S. and Jonas,E.A.
  TITLE     A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics
            during endocytosis
  JOURNAL   Nat Cell Biol 15 (7), 773-785 (2013)
   PUBMED   23792689
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Mettlen,M., Loerke,D., Yarar,D., Danuser,G. and Schmid,S.L.
  TITLE     Cargo- and adaptor-specific mechanisms regulate clathrin-mediated
            endocytosis
  JOURNAL   J Cell Biol 188 (6), 919-933 (2010)
   PUBMED   20231386
  REMARK    GeneRIF: The results underscore the highly dynamic and
            cargo-responsive nature of CCP assembly and suggest that the
            observed heterogeneity is, in part, related to compositional
            differences (e.g., cargo and adaptors) between CCPs.
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Drake,M.T., Downs,M.A. and Traub,L.M.
  TITLE     Epsin binds to clathrin by associating directly with the
            clathrin-terminal domain. Evidence for cooperative binding through
            two discrete sites
  JOURNAL   J Biol Chem 275 (9), 6479-6489 (2000)
   PUBMED   10692452
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Kirchhausen,T., Scarmato,P., Harrison,S.C., Monroe,J.J., Chow,E.P.,
            Mattaliano,R.J., Ramachandran,K.L., Smart,J.E., Ahn,A.H. and
            Brosius,J.
  TITLE     Clathrin light chains LCA and LCB are similar, polymorphic, and
            share repeated heptad motifs
  JOURNAL   Science 236 (4799), 320-324 (1987)
   PUBMED   3563513
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_031974.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213034.1, M15882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000005.1  63041212-63041551
            341-378             JAXUCZ010000005.1  63047169-63047206
            379-496             JAXUCZ010000005.1  63048195-63048312
            497-608             JAXUCZ010000005.1  63052248-63052359
            609-662             JAXUCZ010000005.1  63056566-63056619
            663-698             JAXUCZ010000005.1  63057789-63057824
            699-1140            JAXUCZ010000005.1  63058782-63059223
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1140
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light chain A"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
     exon            1..340
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..870
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     clathrin, light polypeptide (Lca); clathrin, light chain
                     (Lca); lca"
                     /codon_start=1
                     /product="clathrin light chain A isoform 2"
                     /protein_id="NP_114180.1"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKAS
                     NRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLC
                     DFNPKSSKQAKDVSRMRSVLISLKQAPLVH"
     misc_feature    124..402
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="propagated from UniProtKB/Swiss-Prot (P08081.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    187..867
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     misc_feature    187..867
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     misc_feature    421..609
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="propagated from UniProtKB/Swiss-Prot (P08081.1);
                     Region: Involved in binding clathrin heavy chain"
     misc_feature    436..438
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09496; propagated from
                     UniProtKB/Swiss-Prot (P08081.1); phosphorylation site"
     misc_feature    739..741
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09496; propagated from
                     UniProtKB/Swiss-Prot (P08081.1); phosphorylation site"
     misc_feature    790..792
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6IRU5; propagated from
                     UniProtKB/Swiss-Prot (P08081.1); acetylation site"
     misc_feature    829..831
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09496; propagated from
                     UniProtKB/Swiss-Prot (P08081.1); phosphorylation site"
     misc_feature    847..849
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O08585; propagated from
                     UniProtKB/Swiss-Prot (P08081.1); acetylation site"
     exon            341..378
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..608
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..662
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..698
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1140
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctcctc tccgctcgtc ctccggtagc agccgccagc acagtgtccg ctgctgggcg
       61 gggtgtcggc ggatcggtcg gttggtttcg gcttcggtgt cgctgcgttt gagttgggcc
      121 gtcatggctg agttggatcc atttggcgct cccgccggtg cgcccggtgg ccccgcgctc
      181 gggaacgggg tggcgggcgc cggcgaggaa gacccggccg cggccttctt ggcgcagcag
      241 gagagtgaga ttgcgggcat agagaacgac gaggccttcg ccatcctaga cggcggcgcc
      301 cccgggccgc aggcacacgg cgagccgccg gggggtcctg atgcggttga tggagtgatg
      361 aatggcgaat actaccagga gagcaatggt ccaacagaca gttacgcagc catttcagaa
      421 gtggatcggt tgcagtcaga gcctgaaagt atccgtaagt ggagagaaga gcagacagag
      481 cgcctggaag ccctcgatgc caattctcgg aagcaggaag cagagtggaa agaaaaggcc
      541 gtgaaggagc tggaagagtg gtacgcaagg caggacgagc agctacagaa gacaaaagcc
      601 agcaacaggg tggcagatga agctttctac aaacaaccct tcgctgacgt gattggttat
      661 gtcacaaaca taaaccatcc ttgctacagc ctagaacagg cagcagaaga agcctttgta
      721 aacgacattg acgagtcatc cccaggcact gagtgggagc gggtggcccg cctgtgtgac
      781 tttaacccca agtccagcaa acaggccaaa gatgtctctc gcatgcgctc agtcctcatc
      841 tccctgaagc aggcgcccct ggtgcattga agagccaccc tgtggaaaca ctacgtctcc
      901 gatcttaatc ctactcagtg aagctgttca cgcaattgga ttaattatgc cgagttcttt
      961 tggaccaaac cttttgtctt tagagttgat cattgtttgt gattgcatgt ttccttcaac
     1021 tgtgttctcc ctggcattca gagaagagag aggaagagga agggagggga gctcccaaca
     1081 gtagcctcaa cctgtgcttt tgtgcattat tctgagaata aatttctgtt tcaaacaata
//
LOCUS       NM_001436600            2870 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 5, mRNA.
ACCESSION   NM_001436600 XM_039110872
VERSION     NM_001436600.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039110872.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1827183.1,
                                           SRR21887622.3843950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680419, SAMN06680425
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               JAXUCZ010000005.1  126963952-126964380
            430-519             JAXUCZ010000005.1  127018017-127018106
            520-579             JAXUCZ010000005.1  127037215-127037274
            580-646             JAXUCZ010000005.1  127040034-127040100
            647-723             JAXUCZ010000005.1  127040190-127040266
            724-788             JAXUCZ010000005.1  127045623-127045687
            789-837             JAXUCZ010000005.1  127046262-127046310
            838-873             JAXUCZ010000005.1  127046896-127046931
            874-928             JAXUCZ010000005.1  127047469-127047523
            929-999             JAXUCZ010000005.1  127048676-127048746
            1000-1078           JAXUCZ010000005.1  127054592-127054670
            1079-1107           JAXUCZ010000005.1  127055509-127055537
            1108-1209           JAXUCZ010000005.1  127055633-127055734
            1210-2870           JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2870
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..429
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    37..39
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream in-frame stop codon"
     exon            430..519
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..1239
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform d is encoded by transcript variant 5;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform d"
                     /protein_id="NP_001423529.1"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLL
                     PNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINM
                     GPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTM
                     INPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGIS
                     NPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    <517..1167
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    <517..1167
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     exon            520..579
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..646
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            647..723
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..788
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..837
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..873
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            874..928
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..999
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1078
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1107
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1209
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2870
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttgcaaa tgtaggtgga atgcaggaga ggcaactagc tatggcagta ccacagcact
       61 gcctcaggtt ggaatgggcg acactgtacc cagccaggct ctgcctgtgg agtgggagcg
      121 cctgcaagga gactgggggc ctgcttggca gccggcgcct atcagacaac tggaaagtgc
      181 cagtgcttgc gggccatctg tcccctgtgc ctaactccca gccaccttct gcttaccaca
      241 gaagggcccg gcgctgttcc acagcacaag ggcgaggcgc ctgctgggag gggcaggcag
      301 ttttccattt tgcttttgtt tggttccatc ttccttgtag ctcctggtgc tttggtcttg
      361 ccaggtgtgt ggaaagtttg ccggctgctg tcagccagcc ttttggtgga tagctggtgg
      421 gagaaaaaga gtgcagcagc tgccccaagt cctgtgcttg gcaacattcc ccccaatgat
      481 gggatgcctg gaggccccat cccaccaggt ttctttcagc cttttatgtc accgagatat
      541 gcaggcggcc ccaggccccc gatcagaatg ggaaaccagc ctccaggagg agttcctggg
      601 acacagccat tgctgcccaa ttccatggat cccacacgac aacaaggtca ccccaacatg
      661 ggagggtcaa tgcagagaat gaaccctccc cgaggcatgg ggcccatggg gcctggccca
      721 cagaattacg gcagcggcat gagaccacca cccaactccc tcggccccgc catgcctggg
      781 attaacatgg gcccaggagc tggcagaccc tggcccaatc ccaacagtgc taactcaatc
      841 ccgtactcct cctcatcacc cggaacctat gtgggacccc ctggtggtgg cggccctcct
      901 ggaaccccca tcatgcctag tcctgcggat tcaacaaatt ccagtgacaa catctacaca
      961 atgattaatc ctgtgccgcc tggaggcagc cggtctaact ttccaatggg tcctggctca
     1021 gatggcccaa tgggcggcat gggaggcatg gagccacacc acatgaatgg atccttagga
     1081 tcaggcgaca tagatggact tccaaaaaat tctcctaaca acataagtgg cattagcaac
     1141 cctccaggca cccctcggga tgacggcgag ctggggggga acttcctcca ctccttccag
     1201 aacgacaatt attctccaag catgacgatg agtgtgtgat cccttctcca caacgctgag
     1261 agccggcatt gcaggcagaa gatgccagaa attatgcaag aagaagtgag gtgtcgatac
     1321 caggagctgg gggagggcgt ctcctgctcc cctccatccc tcccattctc tcccccacct
     1381 ttcccaattt tagtttcatg caataaaaag gccaaacttt ttattccgtc aaacatgaag
     1441 gacaaaactc agaaatatat ttcaagtcaa cgaccagaaa aatctcacct tctccctgcc
     1501 caaaaggacc tttctgtaca tgacactttt tgttgggttt ttttgtttgt ttgtttgttt
     1561 gtttgtttgg gattttactg ttgctgggat tttaaatttg tttttttggg gggattcttt
     1621 gggggaattt ttttaatgga agcttctagc aagccctatg cccacccaat caacctcatt
     1681 gctttcttct ttaataaaag gaaaaaagga aaaagaaaaa aaaggccaaa aaaaaaaaaa
     1741 aaggaagaaa aacccacaag ccctgctgtc tatccccaag tcctaccacc agaaaagcta
     1801 gtctaggtgt gcaatatcac actgatgttg tagccatcta aaaataataa taataaactg
     1861 gacagtttac aattggtggt ttctttcaaa agctgtttgg ggagaaggaa ctgaagtcaa
     1921 cggtttccac gtgggccttt ggggtttgtg ctgggcaagg agatgcaggt gtccactttg
     1981 ctctggctgg gctggccatc acaacacact gggccagagg acccagagcc cccaacttgc
     2041 cgtcacccaa cagagaccat cgctgtgacc cagcgtacac actgttccag gatggctgcc
     2101 tcttctccaa acctctcatg cccagccaca ggggcctcca gtccctcggt ccccaccgtt
     2161 tcctggcaag aatcctgctg gctgggtagt ggcccaggct gtgtaggaga ggccccacca
     2221 acaggatgac tacaatctgg gccatagaac tgacctccat gttctggtcc cgagctcctc
     2281 acatagtgcg cactggcagg gcgggctgaa gttgtgtttt tctttttttc tcctgtttgt
     2341 cctttttcaa agatgggtgt tggttggaat tgctctgtat ttgcttggaa ctggatggac
     2401 agacttcagc attgctgtgg ggtgggggga gcaccagcaa ccaaacagac actgtttctg
     2461 gtcctgtttt tattttcaaa aactgatgaa cctgatggtg gagcctgtcc cctctgagga
     2521 ggggtgactt ggctgccctg gcctctcccc gtggcaacca ttgtgtcttg ctccggaaga
     2581 cactgagttc tttgtacatt taccccctct gtgccccgcc catcctcgta gctggtcttt
     2641 gttttcttac ctcccctttc tgacccatgt atatcatatt atgtgagata ccatctgcct
     2701 gacaaaagac ttgtgcggat ccttgggaac attgtagctg tttctgtgtt ttttcttacc
     2761 ttgtagtctg gttctgaatt atgagaggaa aaaaagtaat tatgatacat tgtagtttgt
     2821 gtacgatata tgttgataac gttttattaa agggacatct tttttccgca
//
LOCUS       NM_001436636            4907 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus MYB proto-oncogene like 1 (Mybl1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436636 XM_006237752
VERSION     NM_001436636.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4907)
  AUTHORS   Zhang,D., Xie,D., Lin,X., Ma,L., Chen,J., Zhang,D., Wang,Y.,
            Duo,S., Feng,Y., Zheng,C., Jiang,B., Ning,Y. and Han,C.
  TITLE     The transcription factor SOX30 is a key regulator of mouse
            spermiogenesis
  JOURNAL   Development 145 (11) (2018)
   PUBMED   29848638
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4907)
  AUTHORS   Li,X.Z., Roy,C.K., Dong,X., Bolcun-Filas,E., Wang,J., Han,B.W.,
            Xu,J., Moore,M.J., Schimenti,J.C., Weng,Z. and Zamore,P.D.
  TITLE     An ancient transcription factor initiates the burst of piRNA
            production during early meiosis in mouse testes
  JOURNAL   Mol Cell 50 (1), 67-81 (2013)
   PUBMED   23523368
REFERENCE   3  (bases 1 to 4907)
  AUTHORS   Bolcun-Filas,E., Bannister,L.A., Barash,A., Schimenti,K.J.,
            Hartford,S.A., Eppig,J.J., Handel,M.A., Shen,L. and Schimenti,J.C.
  TITLE     A-MYB (MYBL1) transcription factor is a master regulator of male
            meiosis
  JOURNAL   Development 138 (15), 3319-3330 (2011)
   PUBMED   21750041
REFERENCE   4  (bases 1 to 4907)
  AUTHORS   Ma,X.P. and Calabretta,B.
  TITLE     DNA binding and transactivation activity of A-myb, a c-myb-related
            gene
  JOURNAL   Cancer Res 54 (24), 6512-6516 (1994)
   PUBMED   7987850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237752.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.811419.1,
                                           SRR21887622.236336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000005.1  14365754-14366144
            392-497             JAXUCZ010000005.1  14374290-14374395
            498-569             JAXUCZ010000005.1  14374701-14374772
            570-662             JAXUCZ010000005.1  14377334-14377426
            663-883             JAXUCZ010000005.1  14379756-14379976
            884-1058            JAXUCZ010000005.1  14381472-14381646
            1059-1130           JAXUCZ010000005.1  14384029-14384100
            1131-1235           JAXUCZ010000005.1  14385306-14385410
            1236-1469           JAXUCZ010000005.1  14388742-14388975
            1470-1838           JAXUCZ010000005.1  14390071-14390439
            1839-1981           JAXUCZ010000005.1  14393986-14394128
            1982-2096           JAXUCZ010000005.1  14394526-14394640
            2097-2213           JAXUCZ010000005.1  14395703-14395819
            2214-2318           JAXUCZ010000005.1  14396044-14396148
            2319-4907           JAXUCZ010000005.1  14398424-14401012
FEATURES             Location/Qualifiers
     source          1..4907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4907
                     /gene="Mybl1"
                     /note="MYB proto-oncogene like 1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
     exon            1..391
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    366..368
                     /gene="Mybl1"
                     /note="upstream in-frame stop codon"
     CDS             372..2447
                     /gene="Mybl1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myb-related protein A; myeloblastosis oncogene-like 1"
                     /codon_start=1
                     /product="myb-related protein A isoform 3"
                     /protein_id="NP_001423565.1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
                     /translation="MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDD
                     KLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV
                     QKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNR
                     WAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHL
                     QTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMS
                     AENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQN
                     SPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDLSDAAASPVKSTPV
                     KLMRIQHNEGAMECQFNVSLVLEGKKNSCNGGDSEAIPLASPNVVKFSTPPTILRKKK
                     RLRVGQSAGSELGEGSLSEGNNAALKHTPVKTLPFSPSQFFNTCPGSEQLNIENPSFT
                     STPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQE
                     KKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRK
                     SLALESWDKEEPGTQLLTEDISDMQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTAP
                     SSTSRALIL"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1824..2294
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     misc_feature    1824..2294
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     exon            392..497
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..569
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..662
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..883
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1058
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1130
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1235
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1469
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1838
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1981
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2096
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2213
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2318
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..4907
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctgc tcgctgcggg gagagggcgg gggtcggcgc ccgtgacgga gccgcgcagg
       61 gccggcagct ccaaggcgga ggcggaggcg gcgggagggg cgggcggagg gcgggagcac
      121 ggctcctgac atgtccaggg catccctggc cgggccgggc cgcggctagg agcagcgggt
      181 cttggtccgc ccctctgtcc ctcagtcccg cctggccctg acctgtcggg gcctgcgttc
      241 cgctctctcg gccacctgag ggaaggagcg gggtaagcgg cgggtgggtc tcggagaggg
      301 cgcactcgcc ccaggctgga ggaggctgac ccgcgtcccc gcccagcccg cgcctatgcg
      361 gtacttgaag gatggcgaag aggtcgcgca gtgaggatga ggacgatgac cttcagtatg
      421 ctgatcatga ttatgaagta cctcaacaaa aaggactgaa aaaactctgg aacagagtaa
      481 aatggaccag agatgaggat gacaagttaa agaagttggt tgaacaacac ggaactgatg
      541 attggactct aattgctagt catcttcaaa atcgttctga ttttcagtgc caacatcgat
      601 ggcagaaggt tttaaatcca gaattgataa agggtccttg gacgaaggaa gaagatcaga
      661 gggttattga attagttcag aaatatgggc caaaaaggtg gtctttaatt gcaaaacatt
      721 taaaaggaag aataggcaag cagtgcagag aaagatggca caatcacctg aaccccgagg
      781 taaagaagtc ttcttggaca gaggaagaag acaggatcat atacgaagcg cacaagcggc
      841 tgggaaaccg ttgggccgag attgcgaagt tacttcctgg aaggactgat aattctatca
      901 aaaatcattg gaattctacc atgagaagaa aagtggagca ggagggctac ttacaagacg
      961 gaataaaatc agagcggtct tcatccaaac ttcaacacaa accttgtgcg actatggacc
     1021 atttgcaaac ccagaatcag ttttacattc ctgttcagat ccctggttat cagtatgtgt
     1081 cacctgatgg caattgtgtt gaacatgtcc agacatctgc ctttattcag caaccctttg
     1141 ttgatgaaga tcctgataaa gagaaaaaaa taaaggagct cgagttgctt cttatgtcag
     1201 ctgagaatga agttagaaga aagaggcttc cacctcaacc tggaagcttt tctagctggt
     1261 ctggtagttt cctcatggat gatagtatgt ctaacacgct gaataatctt gaggagcaca
     1321 ctactgagtt ttatagcatg gatgaaaatc agactgtttc tgcccagcag aactcaccca
     1381 caaagtttct agctgtagaa gcaaatgctg tgctgtcctc tctacagacc atcccagaat
     1441 ttgcagaaac tctagaactt attgaatcgg atcctgtagc atggagtgat gttaccagtt
     1501 ttgatctttc tgatgctgct gcttctcctg tcaagtctac tccagttaaa ttaatgagaa
     1561 ttcagcataa tgaaggagcc atggaatgtc aatttaacgt cagtcttgtc cttgaaggga
     1621 aaaagaacag ttgtaatggt ggagacagtg aagctattcc tttagcatcc ccaaatgtgg
     1681 tcaagtttag cactccacca actatcctca gaaagaagaa aagactacga gtgggtcagt
     1741 ctgcaggcag tgagcttggt gaaggctcac tcagtgaggg caataacgca gccctgaagc
     1801 acacaccagt aaaaacacta ccgttttctc cttcacagtt ctttaacaca tgccctggaa
     1861 gtgaacaact taatatagaa aacccttcct ttacatcaac cccaatttgt ggacagaaag
     1921 ttcttattac aactcctctt caaaaggaag cgacccccaa agatcaaaaa gaaaatgtag
     1981 ggtttagaac acctactatt agaagatcga tactgggcac cacaccaaga actcctactc
     2041 cttttaagaa tgcacttgct gctcaggaaa agaaatatgg acctcttaaa attgtgtccc
     2101 agccacttgc cttcttggaa gaagacattc gagaggtttt aaaagaagaa actggaacag
     2161 atatattcct caaagaggaa gatgaacccg cttacaaaag ctgcaaacaa gagcactctg
     2221 catctgtgaa gaaagtcaga aagtcactgg ccttagagag ctgggacaaa gaagaaccgg
     2281 gcacccagct gctaactgaa gacatttcag acatgcagtc aaattgtgaa tgggaaacag
     2341 tggtatacgg gaagacagaa gaccaactca tcatgactga acaagcaaga agatacctga
     2401 gcacttacac agctcccagc agcacatcga gagctctgat actctaactg ttactgaagc
     2461 tgatgaaagg ccccaccccc tactgtgctt atgctaaatt aggttgcaat gaaatttgtc
     2521 tcaattaatt cttttaaagg ttttaataca tccctaaaat ggttcgcggt tttttctata
     2581 ttgaacaggc aaaaacctaa taagccactt aacgtaaggg gtaggcaaat ttattataaa
     2641 tatattttta agaaatgaga gttttaaagc ttgtttttaa agaacaaagt gggaaaataa
     2701 ggatgttcat gggtattcca aagtcaattc tcacgttaat ttctttccag gatatatgtc
     2761 gctactttct caaggccgta gtctgttata aacaagttag gtgtgcgtgg cctctgaaag
     2821 tctgtgttta ggaagcacag aggctttatg aagtactttt gcatgtgtgc tgatttactt
     2881 agagaaacac agtgggaagg agcctcaagg aagctagaag ttgcactact aattttggta
     2941 tttttcagaa acaatgaaat taactacagt gttaaggata tttatttgtg catagtacta
     3001 aaaaagcatt gaaaaaaagg ctttttctta ctagtaaaga gtcagtattt cttcataagt
     3061 ctcagaagag ctgagaattt tgttgaatgt attgtacagt atgtaggagc aagaaaactt
     3121 tgtaaattgg aaagatgtct gtttttataa cttattttca tttttaaagc ttaaatgtag
     3181 atatttatat atacagggtg tctagaagcc agtgttgttt cttgccatta cagctaacat
     3241 agtaaagaat aactttgact ttcaagtatg aaatagttaa gttatagctt caaagaatac
     3301 aatatctata ctgtatgtca catctaccta aatattgcac tatatccttt aaatcatgtt
     3361 ggttataaag tagttctaaa atgtactaaa taataattta atattttctt tttaaattat
     3421 attggagggt catataaatt aatctggtga tttgtatatg tgtttgaaat tttcattttg
     3481 tttaaaaaac aatatggtac cttgctccct aaaacagtct gcacttagaa gtttattgta
     3541 tttactcaat gtttcagaag tagaaaatat tatcttttat ttatacaaat attttgtcct
     3601 tttataaatg ttttgtgttt ccaggttaca atagttgctt cagttgcctg tttaggtgtt
     3661 tgcacttact ttatctcttt ttgaaagaat gtctttgctt atgtggtaga gatttatgta
     3721 attttttgag acgtataatg gtgtgctgtc aacctaaaca ctgacaggca gatagaattg
     3781 tacactgtag tttgaattat ttataattga cacactctct ccctctccac tcctgaagta
     3841 tgctgctata gaaagtagca gagtcggctt gctgctatga gagatggaaa gagcaaccac
     3901 cacttgcact gtgtgaaaag ataagcaaat gatggccagt tctcaagtta actaatggat
     3961 tcaacgattc ccaagcaggt tcttaaaaga ccaaacacca ctgtgcctca aaaccaaacc
     4021 aaactgaaca gcttaagatt tttttaaaac tctacttatc tgttaataga aatgggacta
     4081 ctgaatattt taatgcctag ttcttcaaca gtagacctaa agggttttaa gctttaaatc
     4141 caattgctag tttttgcata ctatatgtta gtgagaagta aagaatatgt gtggtggtac
     4201 taagattatg cctcttgata acaaataggt aaaacaattt gaatcttctt agcatgttaa
     4261 atatgttgat ttttttctaa ttaatgaact tctcacagaa attttgcttt gtaaaaccaa
     4321 tgattgtgga aaaaaaatca tactctatca tttcagttac tttggggtaa taatagcaca
     4381 taattctttt ttttaaaaaa aaatgtagcc tttagctgca ttggatataa taatctccag
     4441 ttgccaaagt aaaatatctc agacacgcta catattttaa aacataattt ttcttgagca
     4501 ttaagttagc acaaatgtta atacattgtc cataagcctg ggcttatggg acataggaca
     4561 tatttgggtt ggtattggtt gaatcctcca gttaactgct ttgttgcttt ttgcaagatt
     4621 tgtaatcata aacatgttag gcatcttaag tcatcttttt ttactgttca cttatattct
     4681 tcagttttct gaagatgcca agcatacagg tagcagccat ccgtgcatgg aaactgactt
     4741 cacacatacc aatactgcat tctgttgtaa ggttttcaca ttaatacagc aattacactg
     4801 actaaattga gttttttaat atataaaaaa aaaactttgc attgtaagag aatcttgcag
     4861 acaatgttga aatctattaa catccaaata aaagcatctg tgtacaa
//
LOCUS       NM_001436622            2791 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436622 XM_006237722
VERSION     NM_001436622.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 2791)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 2791)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 2791)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 2791)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 2791)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237722.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20317.1,
                                           SRR26643294.20212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-2791           JAXUCZ010000005.1  6905690-6906241
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2791
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423551.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2791
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagg gagtccattt ttactcaaga acaaactaag tctgtctgtc
     2281 gtctgcatag tctccctgcc tgttcctacc cttgaagctc cttatgctgg gaaggctgtt
     2341 tgtttgtttt tttaagaaat agaatattta atctgaataa gtgtttattt aaatgtgtaa
     2401 tgctttgaaa ataatgggca acagagaact aaaggatgtt tataaagtga gcttgttggc
     2461 tccatttata aatatatacg atttataagc ttttttaaaa caaagctcaa attgtgggta
     2521 tttttctaaa atgtgcacag ctgtattttc catgaaggat ctttctaatg ggttgttata
     2581 ctgtactcta cattttggac agcacatgaa gtctgccaat gtacttaata aaacatgact
     2641 ttgtttattt aaagtttctt gctgtgaaaa accctaccag tgggttcctt aatttataat
     2701 ccttaaaacc aaaatgtata atgtacagtt tccacaactg taactgccct aataaaaatg
     2761 ttggttatta ataaagttcg agatgtcttt c
//
LOCUS       NM_001106630            2508 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 2,
            mRNA.
ACCESSION   NM_001106630 XM_001059299 XM_232578
VERSION     NM_001106630.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_001106630.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-2508           JAXUCZ010000005.1  6908333-6908601
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2508
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001100100.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2508
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagg gtcatttcca aagtttggcc atcatgaata gagcagcagt
     2281 gaacatggta gagcaagtgc ctctgtggta agaggaaatg tcccttgggc acatccctaa
     2341 gtgtggtata gcaggatccc acagaagatc acttgccatc ttttaagtaa gtatcatgct
     2401 gattcccata ttgactttct caggcaaacg taaaaatgtg aagaatattg agtattcagc
     2461 aaaatccatt tttctccccc aaaaagtaat aaaggcctat ttcaggac
//
LOCUS       NM_001106632            5081 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus MYB proto-oncogene like 1 (Mybl1), transcript
            variant 2, mRNA.
ACCESSION   NM_001106632 XM_001060705 XM_232620
VERSION     NM_001106632.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5081)
  AUTHORS   Zhang,D., Xie,D., Lin,X., Ma,L., Chen,J., Zhang,D., Wang,Y.,
            Duo,S., Feng,Y., Zheng,C., Jiang,B., Ning,Y. and Han,C.
  TITLE     The transcription factor SOX30 is a key regulator of mouse
            spermiogenesis
  JOURNAL   Development 145 (11) (2018)
   PUBMED   29848638
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5081)
  AUTHORS   Li,X.Z., Roy,C.K., Dong,X., Bolcun-Filas,E., Wang,J., Han,B.W.,
            Xu,J., Moore,M.J., Schimenti,J.C., Weng,Z. and Zamore,P.D.
  TITLE     An ancient transcription factor initiates the burst of piRNA
            production during early meiosis in mouse testes
  JOURNAL   Mol Cell 50 (1), 67-81 (2013)
   PUBMED   23523368
REFERENCE   3  (bases 1 to 5081)
  AUTHORS   Bolcun-Filas,E., Bannister,L.A., Barash,A., Schimenti,K.J.,
            Hartford,S.A., Eppig,J.J., Handel,M.A., Shen,L. and Schimenti,J.C.
  TITLE     A-MYB (MYBL1) transcription factor is a master regulator of male
            meiosis
  JOURNAL   Development 138 (15), 3319-3330 (2011)
   PUBMED   21750041
REFERENCE   4  (bases 1 to 5081)
  AUTHORS   Ma,X.P. and Calabretta,B.
  TITLE     DNA binding and transactivation activity of A-myb, a c-myb-related
            gene
  JOURNAL   Cancer Res 54 (24), 6512-6516 (1994)
   PUBMED   7987850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_001106632.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000005.1  14365754-14366144
            392-497             JAXUCZ010000005.1  14374290-14374395
            498-569             JAXUCZ010000005.1  14374701-14374772
            570-662             JAXUCZ010000005.1  14377334-14377426
            663-883             JAXUCZ010000005.1  14379756-14379976
            884-1052            JAXUCZ010000005.1  14381472-14381640
            1053-1124           JAXUCZ010000005.1  14384029-14384100
            1125-1229           JAXUCZ010000005.1  14385306-14385410
            1230-1463           JAXUCZ010000005.1  14388742-14388975
            1464-1832           JAXUCZ010000005.1  14390071-14390439
            1833-1975           JAXUCZ010000005.1  14393986-14394128
            1976-2090           JAXUCZ010000005.1  14394526-14394640
            2091-2207           JAXUCZ010000005.1  14395703-14395819
            2208-2312           JAXUCZ010000005.1  14396044-14396148
            2313-2492           JAXUCZ010000005.1  14396575-14396754
            2493-5081           JAXUCZ010000005.1  14398424-14401012
FEATURES             Location/Qualifiers
     source          1..5081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..5081
                     /gene="Mybl1"
                     /note="MYB proto-oncogene like 1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
     exon            1..391
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    366..368
                     /gene="Mybl1"
                     /note="upstream in-frame stop codon"
     CDS             372..2621
                     /gene="Mybl1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myb-related protein A; myeloblastosis oncogene-like 1"
                     /codon_start=1
                     /product="myb-related protein A isoform 2"
                     /protein_id="NP_001100102.1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
                     /translation="MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDD
                     KLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV
                     QKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNR
                     WAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHL
                     QTQNQFYIPIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAE
                     NEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSP
                     TKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKL
                     MRIQHNEGAMECQFNVSLVLEGKKNSCNGGDSEAIPLASPNVVKFSTPPTILRKKKRL
                     RVGQSAGSELGEGSLSEGNNAALKHTPVKTLPFSPSQFFNTCPGSEQLNIENPSFTST
                     PICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKK
                     YGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSL
                     ALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSAN
                     KTYTLTKKRPNPNTCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTAP
                     SSTSRALIL"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    1083..1220
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1083..1220
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1818..2288
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     misc_feature    1818..2288
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     exon            392..497
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..569
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..662
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..883
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1052
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1124
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1229
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1463
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1832
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1975
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2090
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2207
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2312
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2492
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..5081
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctgc tcgctgcggg gagagggcgg gggtcggcgc ccgtgacgga gccgcgcagg
       61 gccggcagct ccaaggcgga ggcggaggcg gcgggagggg cgggcggagg gcgggagcac
      121 ggctcctgac atgtccaggg catccctggc cgggccgggc cgcggctagg agcagcgggt
      181 cttggtccgc ccctctgtcc ctcagtcccg cctggccctg acctgtcggg gcctgcgttc
      241 cgctctctcg gccacctgag ggaaggagcg gggtaagcgg cgggtgggtc tcggagaggg
      301 cgcactcgcc ccaggctgga ggaggctgac ccgcgtcccc gcccagcccg cgcctatgcg
      361 gtacttgaag gatggcgaag aggtcgcgca gtgaggatga ggacgatgac cttcagtatg
      421 ctgatcatga ttatgaagta cctcaacaaa aaggactgaa aaaactctgg aacagagtaa
      481 aatggaccag agatgaggat gacaagttaa agaagttggt tgaacaacac ggaactgatg
      541 attggactct aattgctagt catcttcaaa atcgttctga ttttcagtgc caacatcgat
      601 ggcagaaggt tttaaatcca gaattgataa agggtccttg gacgaaggaa gaagatcaga
      661 gggttattga attagttcag aaatatgggc caaaaaggtg gtctttaatt gcaaaacatt
      721 taaaaggaag aataggcaag cagtgcagag aaagatggca caatcacctg aaccccgagg
      781 taaagaagtc ttcttggaca gaggaagaag acaggatcat atacgaagcg cacaagcggc
      841 tgggaaaccg ttgggccgag attgcgaagt tacttcctgg aaggactgat aattctatca
      901 aaaatcattg gaattctacc atgagaagaa aagtggagca ggagggctac ttacaagacg
      961 gaataaaatc agagcggtct tcatccaaac ttcaacacaa accttgtgcg actatggacc
     1021 atttgcaaac ccagaatcag ttttacattc ctatccctgg ttatcagtat gtgtcacctg
     1081 atggcaattg tgttgaacat gtccagacat ctgcctttat tcagcaaccc tttgttgatg
     1141 aagatcctga taaagagaaa aaaataaagg agctcgagtt gcttcttatg tcagctgaga
     1201 atgaagttag aagaaagagg cttccacctc aacctggaag cttttctagc tggtctggta
     1261 gtttcctcat ggatgatagt atgtctaaca cgctgaataa tcttgaggag cacactactg
     1321 agttttatag catggatgaa aatcagactg tttctgccca gcagaactca cccacaaagt
     1381 ttctagctgt agaagcaaat gctgtgctgt cctctctaca gaccatccca gaatttgcag
     1441 aaactctaga acttattgaa tcggatcctg tagcatggag tgatgttacc agttttgatc
     1501 tttctgatgc tgctgcttct cctgtcaagt ctactccagt taaattaatg agaattcagc
     1561 ataatgaagg agccatggaa tgtcaattta acgtcagtct tgtccttgaa gggaaaaaga
     1621 acagttgtaa tggtggagac agtgaagcta ttcctttagc atccccaaat gtggtcaagt
     1681 ttagcactcc accaactatc ctcagaaaga agaaaagact acgagtgggt cagtctgcag
     1741 gcagtgagct tggtgaaggc tcactcagtg agggcaataa cgcagccctg aagcacacac
     1801 cagtaaaaac actaccgttt tctccttcac agttctttaa cacatgccct ggaagtgaac
     1861 aacttaatat agaaaaccct tcctttacat caaccccaat ttgtggacag aaagttctta
     1921 ttacaactcc tcttcaaaag gaagcgaccc ccaaagatca aaaagaaaat gtagggttta
     1981 gaacacctac tattagaaga tcgatactgg gcaccacacc aagaactcct actcctttta
     2041 agaatgcact tgctgctcag gaaaagaaat atggacctct taaaattgtg tcccagccac
     2101 ttgccttctt ggaagaagac attcgagagg ttttaaaaga agaaactgga acagatatat
     2161 tcctcaaaga ggaagatgaa cccgcttaca aaagctgcaa acaagagcac tctgcatctg
     2221 tgaagaaagt cagaaagtca ctggccttag agagctggga caaagaagaa ccgggcaccc
     2281 agctgctaac tgaagacatt tcagacatgc agtcagaaaa tattcttaca acatctttat
     2341 taatgatacc attattggaa atacatgaca ataggtgcaa cttgactcct gaaaaacaag
     2401 atataaattc agccaacaaa acatatacac ttactaaaaa gagaccaaac cctaacactt
     2461 gtaaagctgt caaattggaa aagagtcttc agtcaaattg tgaatgggaa acagtggtat
     2521 acgggaagac agaagaccaa ctcatcatga ctgaacaagc aagaagatac ctgagcactt
     2581 acacagctcc cagcagcaca tcgagagctc tgatactcta actgttactg aagctgatga
     2641 aaggccccac cccctactgt gcttatgcta aattaggttg caatgaaatt tgtctcaatt
     2701 aattctttta aaggttttaa tacatcccta aaatggttcg cggttttttc tatattgaac
     2761 aggcaaaaac ctaataagcc acttaacgta aggggtaggc aaatttatta taaatatatt
     2821 tttaagaaat gagagtttta aagcttgttt ttaaagaaca aagtgggaaa ataaggatgt
     2881 tcatgggtat tccaaagtca attctcacgt taatttcttt ccaggatata tgtcgctact
     2941 ttctcaaggc cgtagtctgt tataaacaag ttaggtgtgc gtggcctctg aaagtctgtg
     3001 tttaggaagc acagaggctt tatgaagtac ttttgcatgt gtgctgattt acttagagaa
     3061 acacagtggg aaggagcctc aaggaagcta gaagttgcac tactaatttt ggtatttttc
     3121 agaaacaatg aaattaacta cagtgttaag gatatttatt tgtgcatagt actaaaaaag
     3181 cattgaaaaa aaggcttttt cttactagta aagagtcagt atttcttcat aagtctcaga
     3241 agagctgaga attttgttga atgtattgta cagtatgtag gagcaagaaa actttgtaaa
     3301 ttggaaagat gtctgttttt ataacttatt ttcattttta aagcttaaat gtagatattt
     3361 atatatacag ggtgtctaga agccagtgtt gtttcttgcc attacagcta acatagtaaa
     3421 gaataacttt gactttcaag tatgaaatag ttaagttata gcttcaaaga atacaatatc
     3481 tatactgtat gtcacatcta cctaaatatt gcactatatc ctttaaatca tgttggttat
     3541 aaagtagttc taaaatgtac taaataataa tttaatattt tctttttaaa ttatattgga
     3601 gggtcatata aattaatctg gtgatttgta tatgtgtttg aaattttcat tttgtttaaa
     3661 aaacaatatg gtaccttgct ccctaaaaca gtctgcactt agaagtttat tgtatttact
     3721 caatgtttca gaagtagaaa atattatctt ttatttatac aaatattttg tccttttata
     3781 aatgttttgt gtttccaggt tacaatagtt gcttcagttg cctgtttagg tgtttgcact
     3841 tactttatct ctttttgaaa gaatgtcttt gcttatgtgg tagagattta tgtaattttt
     3901 tgagacgtat aatggtgtgc tgtcaaccta aacactgaca ggcagataga attgtacact
     3961 gtagtttgaa ttatttataa ttgacacact ctctccctct ccactcctga agtatgctgc
     4021 tatagaaagt agcagagtcg gcttgctgct atgagagatg gaaagagcaa ccaccacttg
     4081 cactgtgtga aaagataagc aaatgatggc cagttctcaa gttaactaat ggattcaacg
     4141 attcccaagc aggttcttaa aagaccaaac accactgtgc ctcaaaacca aaccaaactg
     4201 aacagcttaa gattttttta aaactctact tatctgttaa tagaaatggg actactgaat
     4261 attttaatgc ctagttcttc aacagtagac ctaaagggtt ttaagcttta aatccaattg
     4321 ctagtttttg catactatat gttagtgaga agtaaagaat atgtgtggtg gtactaagat
     4381 tatgcctctt gataacaaat aggtaaaaca atttgaatct tcttagcatg ttaaatatgt
     4441 tgattttttt ctaattaatg aacttctcac agaaattttg ctttgtaaaa ccaatgattg
     4501 tggaaaaaaa atcatactct atcatttcag ttactttggg gtaataatag cacataattc
     4561 ttttttttaa aaaaaaatgt agcctttagc tgcattggat ataataatct ccagttgcca
     4621 aagtaaaata tctcagacac gctacatatt ttaaaacata atttttcttg agcattaagt
     4681 tagcacaaat gttaatacat tgtccataag cctgggctta tgggacatag gacatatttg
     4741 ggttggtatt ggttgaatcc tccagttaac tgctttgttg ctttttgcaa gatttgtaat
     4801 cataaacatg ttaggcatct taagtcatct ttttttactg ttcacttata ttcttcagtt
     4861 ttctgaagat gccaagcata caggtagcag ccatccgtgc atggaaactg acttcacaca
     4921 taccaatact gcattctgtt gtaaggtttt cacattaata cagcaattac actgactaaa
     4981 ttgagttttt taatatataa aaaaaaaact ttgcattgta agagaatctt gcagacaatg
     5041 ttgaaatcta ttaacatcca aataaaagca tctgtgtaca a
//
LOCUS       NM_001436597            3157 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 2, mRNA.
ACCESSION   NM_001436597 XM_006238535
VERSION     NM_001436597.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 3157)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 3157)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 3157)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 3157)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238535.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724490.1, SRR26643297.19567.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               JAXUCZ010000005.1  126920187-126920601
            416-488             JAXUCZ010000005.1  126921562-126921634
            489-550             JAXUCZ010000005.1  126921854-126921915
            551-635             JAXUCZ010000005.1  126924241-126924325
            636-725             JAXUCZ010000005.1  127018017-127018106
            726-806             JAXUCZ010000005.1  127036252-127036332
            807-866             JAXUCZ010000005.1  127037215-127037274
            867-933             JAXUCZ010000005.1  127040034-127040100
            934-1010            JAXUCZ010000005.1  127040190-127040266
            1011-1075           JAXUCZ010000005.1  127045623-127045687
            1076-1124           JAXUCZ010000005.1  127046262-127046310
            1125-1160           JAXUCZ010000005.1  127046896-127046931
            1161-1215           JAXUCZ010000005.1  127047469-127047523
            1216-1286           JAXUCZ010000005.1  127048676-127048746
            1287-1365           JAXUCZ010000005.1  127054592-127054670
            1366-1394           JAXUCZ010000005.1  127055509-127055537
            1395-1496           JAXUCZ010000005.1  127055633-127055734
            1497-3157           JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3157
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..415
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream in-frame stop codon"
     CDS             360..1526
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform b is encoded by transcript variant 2;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform b"
                     /protein_id="NP_001423526.1"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEI
                     RWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVL
                     GNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGP
                     RPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQN
                     YGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPP
                     GTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGS
                     LGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    600..1454
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    600..1454
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     exon            416..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..550
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..635
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..725
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..806
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..866
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..933
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1010
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1075
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1124
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1160
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1215
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1286
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1365
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1394
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1496
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..3157
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagaccag cggcggcggc ggcagaggca gcggtgctga aggcgcagag ggcggcgcag
       61 gcggagccgg gtggcgggcg cgcgggccgc gagcaagcga gctgcaggct tcgggcgggc
      121 ggcggcgcag ctcaggccga gccggcgcgg gaggagttcc agggcgatgg ggccgcggcc
      181 ggggctgacg ctttgacagc tggaaagagc gcggagccag cgccggggag ggagggagcg
      241 cggcgagcgg agtgcgagcg agcgggcgag cgccgggagg gggccgggag cagggcagct
      301 cgggagaccg gacggtagcg gcggcggcgg cgggctcggc gccctcttct ctgcaagcca
      361 tgtttgccaa aggcaaaggc tcggcggtgc cctcggacgg gcaggctcgg gaaaagttag
      421 ctttatatgt ctacgaatat ttactgcacg taggagcaca gaaatctgca cagaccttct
      481 tatcagagat tcgatgggaa aaaaacatca cactgggtga accgcctggg tttctgcact
      541 cgtggtggtg tgtattttgg gacctttact gtgcagctcc tgaaaggaga gacacttgtg
      601 aacattcaag tgaagcaaaa gcctttcatg attacagtgc agcagctgcc ccaagtcctg
      661 tgcttggcaa cattcccccc aatgatggga tgcctggagg ccccatccca ccaggtttct
      721 ttcagggtcc tccggggtca cagccctcgc cgcacgcaca gcctccacct cacaatccca
      781 gcagcatgat gggaccccac agtcagcctt ttatgtcacc gagatatgca ggcggcccca
      841 ggcccccgat cagaatggga aaccagcctc caggaggagt tcctgggaca cagccattgc
      901 tgcccaattc catggatccc acacgacaac aaggtcaccc caacatggga gggtcaatgc
      961 agagaatgaa ccctccccga ggcatggggc ccatggggcc tggcccacag aattacggca
     1021 gcggcatgag accaccaccc aactccctcg gccccgccat gcctgggatt aacatgggcc
     1081 caggagctgg cagaccctgg cccaatccca acagtgctaa ctcaatcccg tactcctcct
     1141 catcacccgg aacctatgtg ggaccccctg gtggtggcgg ccctcctgga acccccatca
     1201 tgcctagtcc tgcggattca acaaattcca gtgacaacat ctacacaatg attaatcctg
     1261 tgccgcctgg aggcagccgg tctaactttc caatgggtcc tggctcagat ggcccaatgg
     1321 gcggcatggg aggcatggag ccacaccaca tgaatggatc cttaggatca ggcgacatag
     1381 atggacttcc aaaaaattct cctaacaaca taagtggcat tagcaaccct ccaggcaccc
     1441 ctcgggatga cggcgagctg ggggggaact tcctccactc cttccagaac gacaattatt
     1501 ctccaagcat gacgatgagt gtgtgatccc ttctccacaa cgctgagagc cggcattgca
     1561 ggcagaagat gccagaaatt atgcaagaag aagtgaggtg tcgataccag gagctggggg
     1621 agggcgtctc ctgctcccct ccatccctcc cattctctcc cccacctttc ccaattttag
     1681 tttcatgcaa taaaaaggcc aaacttttta ttccgtcaaa catgaaggac aaaactcaga
     1741 aatatatttc aagtcaacga ccagaaaaat ctcaccttct ccctgcccaa aaggaccttt
     1801 ctgtacatga cactttttgt tgggtttttt tgtttgtttg tttgtttgtt tgtttgggat
     1861 tttactgttg ctgggatttt aaatttgttt ttttgggggg attctttggg ggaatttttt
     1921 taatggaagc ttctagcaag ccctatgccc acccaatcaa cctcattgct ttcttcttta
     1981 ataaaaggaa aaaaggaaaa agaaaaaaaa ggccaaaaaa aaaaaaaaag gaagaaaaac
     2041 ccacaagccc tgctgtctat ccccaagtcc taccaccaga aaagctagtc taggtgtgca
     2101 atatcacact gatgttgtag ccatctaaaa ataataataa taaactggac agtttacaat
     2161 tggtggtttc tttcaaaagc tgtttgggga gaaggaactg aagtcaacgg tttccacgtg
     2221 ggcctttggg gtttgtgctg ggcaaggaga tgcaggtgtc cactttgctc tggctgggct
     2281 ggccatcaca acacactggg ccagaggacc cagagccccc aacttgccgt cacccaacag
     2341 agaccatcgc tgtgacccag cgtacacact gttccaggat ggctgcctct tctccaaacc
     2401 tctcatgccc agccacaggg gcctccagtc cctcggtccc caccgtttcc tggcaagaat
     2461 cctgctggct gggtagtggc ccaggctgtg taggagaggc cccaccaaca ggatgactac
     2521 aatctgggcc atagaactga cctccatgtt ctggtcccga gctcctcaca tagtgcgcac
     2581 tggcagggcg ggctgaagtt gtgtttttct ttttttctcc tgtttgtcct ttttcaaaga
     2641 tgggtgttgg ttggaattgc tctgtatttg cttggaactg gatggacaga cttcagcatt
     2701 gctgtggggt ggggggagca ccagcaacca aacagacact gtttctggtc ctgtttttat
     2761 tttcaaaaac tgatgaacct gatggtggag cctgtcccct ctgaggaggg gtgacttggc
     2821 tgccctggcc tctccccgtg gcaaccattg tgtcttgctc cggaagacac tgagttcttt
     2881 gtacatttac cccctctgtg ccccgcccat cctcgtagct ggtctttgtt ttcttacctc
     2941 ccctttctga cccatgtata tcatattatg tgagatacca tctgcctgac aaaagacttg
     3001 tgcggatcct tgggaacatt gtagctgttt ctgtgttttt tcttaccttg tagtctggtt
     3061 ctgaattatg agaggaaaaa aagtaattat gatacattgt agtttgtgta cgatatatgt
     3121 tgataacgtt ttattaaagg gacatctttt ttccgca
//
LOCUS       NM_001436614            2554 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 3, mRNA.
ACCESSION   NM_001436614 XM_006253321
VERSION     NM_001436614.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006253321.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1857597.1,
                                           SRR26643293.75522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000016.1  73925752-73925871
            121-200             JAXUCZ010000016.1  73926790-73926869
            201-256             JAXUCZ010000016.1  73927485-73927540
            257-335             JAXUCZ010000016.1  73929777-73929855
            336-412             JAXUCZ010000016.1  73930126-73930202
            413-590             JAXUCZ010000016.1  73931687-73931864
            591-656             JAXUCZ010000016.1  73932826-73932891
            657-728             JAXUCZ010000016.1  73934031-73934102
            729-886             JAXUCZ010000016.1  73934279-73934436
            887-968             JAXUCZ010000016.1  73935273-73935354
            969-1105            JAXUCZ010000016.1  73939574-73939710
            1106-1295           JAXUCZ010000016.1  73941664-73941853
            1296-1391           JAXUCZ010000016.1  73946164-73946259
            1392-1587           JAXUCZ010000016.1  73947426-73947621
            1588-1678           JAXUCZ010000016.1  73957828-73957918
            1679-1895           JAXUCZ010000016.1  73958685-73958901
            1896-1982           JAXUCZ010000016.1  73973622-73973708
            1983-2097           JAXUCZ010000016.1  73974416-73974530
            2098-2260           JAXUCZ010000016.1  73981312-73981474
            2261-2314           JAXUCZ010000016.1  73983410-73983463
            2315-2554           JAXUCZ010000016.1  74001115-74001354
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2554
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2387
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; a disintegrin and metalloprotease domain (ADAM)
                     5; tMDC II; a disintegrin and metalloprotease domain 5;
                     disintegrin and metalloproteinase domain-containing
                     protein 5; transmembrane metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein II; a
                     disintegrin and metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 2 precursor"
                     /protein_id="NP_001423543.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MFLLLLLVVHLNGLQAGQHPQKTILQTTVPEKISSPDVETDPEN
                     HMAYLITINENPHFIHLKKQSFITSTAVSYTYDRQDVRHSQSLSSLKNCNYNGYVAGF
                     PNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTY
                     SWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGF
                     INTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFV
                     EHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCH
                     CTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRI
                     CGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLC
                     RKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKY
                     VRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQ
                     IRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLV
                     DFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSA
                     KQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVS
                     NTKMTTNEGRSSADPPITPNPERILNVFAVKKH"
     sig_peptide     66..113
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    141..491
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    141..491
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    618..1199
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    618..1199
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1260..1484
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1260..1484
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1494..1925
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1494..1925
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            121..200
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            201..256
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            257..335
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            336..412
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            413..590
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            591..656
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            657..728
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            729..886
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            887..968
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1105
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1295
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1391
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1587
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1678
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1895
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1982
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2097
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2260
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2314
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2554
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgccctc cccacctgcc tggccagatg ctcctcagct aagctccagg accaccaagg
       61 gagccatgtt cctccttctt ttgctggttg tgcatcttaa tgggctgcag gcaggccaac
      121 atcctcagaa aaccatcctg caaacaactg ttcctgaaaa gatctcatca ccagatgtgg
      181 aaacagatcc agaaaaccat atggcttatc ttattacaat aaatgaaaac ccccatttca
      241 tccatcttaa aaagcaatcg tttataactt caactgcagt gagttataca tatgacagac
      301 aagatgttcg gcattctcag tctttgtcat ctctgaaaaa ttgcaattac aacggatacg
      361 ttgcaggttt tccaaattct atcgtgtcgc tcaccgtttg ctcaggactc aggggaatga
      421 tacaatttga aaatgtctcc tatggaatcg aacctgtgga aaccctgtca ggatttatac
      481 acgtgatcta tgagaacaca aatcagcaag ctaagattcc tgacttagga gagaatcaga
      541 cgtacagttg gtctgatgaa ttagattatc aattccgaag caacatgaag aaatccggat
      601 ttgccgtgtt acggccacgg tacattaaga cggatatcgt cgtggataaa aagctgtttg
      661 attacatggg ctccgacact agggtcgtgc tacagaaagt cattcagatc atcggtttca
      721 ttaacactat gttctccaag ttgaaactga cggttttaat aaattccgtt gaaatctggt
      781 cgaaggaaaa cagaattgat ttcccagagg cacctgaaaa cttactggtc cagtttttac
      841 attggaaaca taagtataga ccgcagcaca tttcatactt actggcattt gtggagcatc
      901 ctgcttccac gggagccctc tatccgggga atctgtgcaa accgatctat ggtgctgcca
      961 ttgccctgta ccctaaaggt ttgtcactag agtcctacag cgtcatcgtc ctacaactac
     1021 tgagcatcgg tataggctta acctatgaca acgctgacag ctgccactgt acaggagacg
     1081 tctgcctgat gacgcccaag gcaatatatt ctgggggtgt gaaggacttc agtacttgta
     1141 gcttggatga cttcaaatac ctgtcaacac aagaccttga atgtctccag gacttgccta
     1201 tggaaagaca aaagaagaag ccttccaggc caaggagaat ctgtggcaac gggatattgg
     1261 aaatgaacga gcagtgtgac tgtggcactt tgaagaattg tacacacaaa aaatgctgtg
     1321 accccatgtc gtgccgactg aagtccaaag ccgtgtgtgg ctccggggag tgctgtggtc
     1381 aggactgcaa ggtaaaaccg gttaatgtac tctgtagaaa gtcgaagaat gaatgtgact
     1441 ttgaggagta ctgtaacgga aatgacgctt actgtgtccc tgacacgttc gcacgcaacg
     1501 ggcagtactg cgactcaggg caagccttct gctacagtgg tctttgtatg acgagtaata
     1561 atcaatgcat gaacttgctc gggaaatatg tgagaggagc ttccttcgca tgctatgaag
     1621 agttcaattc cagaaacgat agatttggca actgtattag aaagttttgt agtttcgaaa
     1681 attctctctg tgggaagttg gtctgtacct ggccattcaa gaggctgctc atgaaagaca
     1741 atatgtctgc ggcttatgga caaatccgag acgatttatg catctctctg tataaaggag
     1801 ggaggccact taagacaaca ttgtcaacat attccgatat gtcagaaaga gacgaaacat
     1861 ttgtaaaaga cggcacaatc tgtggtcctg atatgttttg tttggaaaca cagtgcaaag
     1921 aaacgagatt tttggtggat tttcaacagt gcaatacttc ccgagattgc aatgaccatg
     1981 gggtttgcaa caactttaat cattgtcatt gtgataaagg atataaccct ccctattgtg
     2041 agtcagtaaa aggacagttt ggaagcattg atgacggcca caaatattac attgacgaag
     2101 ggaaaagcgc taagcagcag aatcgtggta ttcacccaaa gcagcaactc cagcttattc
     2161 tgtatataac gctgcccttg attatgatta tctcggctgt atttataaag caaagcaaac
     2221 tgagtcggct atgcggcaga gaaagaagcg aaggcaccag ctgtataaca gaagacagtg
     2281 tgagtaacac caagatgacc accaacgaag gaaggtcatc tgcagaccca ccaatcacac
     2341 caaacccaga aaggattctg aacgtctttg ctgtgaagaa acactaaggg ctggaggaga
     2401 catcccaggc aggaaattat caccaggtct ttcagccctg tcttctcagc gaggtagcct
     2461 tgatatctgg gttccagtac acctttgtgc atgtctaagg aacgtggaat tttatttgcc
     2521 ctctaataaa tgtggtaact gcctataaaa ttga
//
LOCUS       NM_001106638            4926 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 7 (Slc26a7),
            transcript variant 4, mRNA.
ACCESSION   NM_001106638 XM_001055767 XM_232793
VERSION     NM_001106638.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4926)
  AUTHORS   Kiriya,M., Kawashima,A., Fujiwara,Y., Tanimura,Y., Yoshihara,A.,
            Nakamura,Y., Tanigawa,K., Kondo,T. and Suzuki,K.
  TITLE     Thyroglobulin regulates the expression and localization of the
            novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes
  JOURNAL   Endocr J 69 (10), 1217-1225 (2022)
   PUBMED   35644541
  REMARK    GeneRIF: Thyroglobulin regulates the expression and localization of
            the novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes.
REFERENCE   2  (bases 1 to 4926)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4926)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            acid challenge represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   4  (bases 1 to 4926)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   5  (bases 1 to 4926)
  AUTHORS   Kosiek,O., Busque,S.M., Foller,M., Shcheynikov,N., Kirchhoff,P.,
            Bleich,M., Muallem,S. and Geibel,J.P.
  TITLE     SLC26A7 can function as a chloride-loading mechanism in parietal
            cells
  JOURNAL   Pflugers Arch 454 (6), 989-998 (2007)
   PUBMED   17404755
  REMARK    GeneRIF: SLC26A7 is a Cl(-) uptake system under histamine
            stimulation
REFERENCE   6  (bases 1 to 4926)
  AUTHORS   Petrovic,S., Amlal,H., Sun,X., Karet,F., Barone,S. and Soleimani,M.
  TITLE     Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7
            in kidney medullary collecting ducts of Brattleboro rats
  JOURNAL   Am J Physiol Renal Physiol 290 (5), F1194-F1201 (2006)
   PUBMED   16352747
  REMARK    GeneRIF: vasopressin increases the expression of SLC26A7 protein
            through posttranscriptional mechanisms in the outer medullary
            collecting duct
REFERENCE   7  (bases 1 to 4926)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
REFERENCE   8  (bases 1 to 4926)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   9  (bases 1 to 4926)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 4926)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_001106638.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000005.1  32818836-32818928   c
            94-314              JAXUCZ010000005.1  32818355-32818575   c
            315-425             JAXUCZ010000005.1  32786927-32787037   c
            426-598             JAXUCZ010000005.1  32780136-32780308   c
            599-751             JAXUCZ010000005.1  32743404-32743556   c
            752-834             JAXUCZ010000005.1  32734765-32734847   c
            835-982             JAXUCZ010000005.1  32732596-32732743   c
            983-1096            JAXUCZ010000005.1  32730466-32730579   c
            1097-1174           JAXUCZ010000005.1  32721568-32721645   c
            1175-1270           JAXUCZ010000005.1  32720536-32720631   c
            1271-1377           JAXUCZ010000005.1  32712705-32712811   c
            1378-1444           JAXUCZ010000005.1  32704950-32705016   c
            1445-1582           JAXUCZ010000005.1  32701574-32701711   c
            1583-1631           JAXUCZ010000005.1  32698486-32698534   c
            1632-1732           JAXUCZ010000005.1  32689483-32689583   c
            1733-1787           JAXUCZ010000005.1  32685795-32685849   c
            1788-1891           JAXUCZ010000005.1  32685608-32685711   c
            1892-4926           JAXUCZ010000005.1  32681653-32684687   c
FEATURES             Location/Qualifiers
     source          1..4926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..4926
                     /gene="Slc26a7"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
     exon            1..93
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            94..314
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    116..118
                     /gene="Slc26a7"
                     /note="upstream in-frame stop codon"
     CDS             122..1927
                     /gene="Slc26a7"
                     /note="isoform b is encoded by transcript variant 4; anion
                     exchange transporter; solute carrier family 26 (anion
                     exchanger), member 7"
                     /codon_start=1
                     /product="anion exchange transporter isoform b"
                     /protein_id="NP_001100108.1"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
                     /translation="MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLK
                     ENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG
                     TFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQI
                     YAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFAC
                     YCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSA
                     KKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF
                     VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIF
                     TICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKII
                     SINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQ
                     PCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYG
                     DLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV"
     misc_feature    218..1867
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    218..1867
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     exon            315..425
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            426..598
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            599..751
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            752..834
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            835..982
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1096
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1174
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1270
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1377
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1444
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1582
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1631
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1732
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1787
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1891
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..4926
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaccatct caccgccgaa cccattcctt ttccaagatc agaaaagtag tacatgaaca
       61 gggacccatt tcttattgag ataagaactc aagttgacta ctacaggagg gaatctgaga
      121 aatgacgggg gcaaagagga aaaagagaag cgtgctgtgg ggcaagatgc acacccccca
      181 ccgagaagac attaaacagt ggtgtaagag gcgcctacct atcttggaat gggcaccgca
      241 gtacaatctg aaggaaaacc tgcttccaga caccgtgtct ggcgtactgt tggcagttca
      301 acaggtgaca caagggctgt ccttcgctat tctttcatct gtacacccag tttttggttt
      361 atacggatct ctgtttcctg ccatcattta tgcgatattt ggaatgggac gccatgttgc
      421 cacaggcacc tttgccttga cgtccttgat atcagccaat gctgtggaac ggctggtccc
      481 tcagagcaat agaaacctca ccacacagag caactcaagc gtgctgggct tatcggagtt
      541 tgagctgcag agaatcgggg ttgcagcagc cgtttcattc ttgggcggag tgattcagat
      601 ctatgcgtat gtttttgaga acatcaagtc tgtccagctg gaagcactgc tcttgtcctt
      661 gctgagcatt gttgtccttg tcctcgttaa agagctgaac gagcagttta agagaaagat
      721 taaagttgtt cttcctgtcg acttagtttt gatcattgct gcctcatttg cttgctattg
      781 taccaacatg gaaaacacat acggattaga agtagttggg cgcattccaa aagggatccc
      841 tccgccccgt gctcccccaa tgaacatcct ctccgcagtg ctcacggaag ctttcggagt
      901 tgcacttgta ggctacgtgg cctcgctggc tctcgcacaa ggatctgcca agaagttcaa
      961 atattcagtt gatgacaacc aggaattttt ggcccatggc ctcagcaacg tgattccttc
     1021 atttctcttc tgcatcccaa gcgccgccgc catgggaagg acagctggtc tgtacagcac
     1081 gggggcaaag acacaggtgg cttgtctaat atcttgcatt ttcgtcctta tagtcatcta
     1141 tgcaatagga cccttgctgt actggctgcc catgtgcgtt cttgcaagta ttattgttgt
     1201 gggactgaaa ggaatgttaa tacagttccg ggatttaaaa aaatactgga atgtggataa
     1261 aatcgattgg ggcatatgga tcagcactta catttttaca atatgcttcg ctgccaacgt
     1321 gggactgctc tttggtgttg tctgcaccat agctatcgtg ttagggcgtt tcccaagggc
     1381 aaagacttta agcataacag acatgaaaga aatggaattg aaggtgaaga cagaaacgta
     1441 tgatgaaaac tcgcaacaga taaaaatcat ctcaataaac aacccacttg ttttcctgaa
     1501 tgcaaagaaa tttagtgctg atcttatgaa aataatccta aaggaaactg acggcagcca
     1561 agcacttgat gatgtcagca agtgtgaaca gaacaccttg ctcagtcccc tgcccaacgg
     1621 gagctgcact gaagaagcct cccagccctg ccccagtgag aagtattctt tggtcctgaa
     1681 ttgcagtggc ttgacctttt tcgactacac aggagtctcc acacttgttg agctctacct
     1741 tgattgcaag agcaggagtg tggatgtgtt cttagccaac tgtacagcat ccttgataaa
     1801 agcgatgaca tactatggag acctagacac tgaaaaacca attttttttg actcggtagc
     1861 cactgcaata agtgtcatcc aatcaaataa gaatttgagc aaggacactg accacagtga
     1921 agtctgaggt ccacgcattg aaatgcacat ctcatcttta gcacctgccc caaagaggcc
     1981 agatactggc attttgcact cattttggtg tatatactgt atatctctta attagaatga
     2041 tgtgagttgg caactggata gccactggcc aagacttgct gacatcctat tttttctaat
     2101 ttttcttaat aaacagattc attagttatt tcatataggc atcaatatgc atgtagcttt
     2161 agtttaatga acagtaaaca tgcttttatt tccagttata agagtatttt gtatggtttc
     2221 atttttgttg taagctaaca aatggagaaa tatttttatc agaaatggtt tggattattt
     2281 ataaaccatt cataaaaaaa ttaagatcat ctagtacata aaaaagtatt aacaaatgtg
     2341 ccatttctcc atagttttta tcccaaaatt atttgaacat cagttagata aagtatcact
     2401 tttatacagg gaaaatgaaa tccatagata taaaacaagt gagaaagaga caaattagaa
     2461 gttattaatg tcaatgccca tcaacacact cactctgaca atattcatat attcaattat
     2521 gagttcatat ttggaagaaa actaatgttt tagcaaaact aagttcttga tgtttatctg
     2581 ctgaattgtg gatactggag accatttgtg tgtttaatca gataactctg acttctgcat
     2641 tgcaacacat aagatattct gctttcaaac ttctttcttg caatcagaga atatgagaat
     2701 ttgatatgta ttttttcaaa aatatgcatt tttcaatgat aaaatatcat aagtagaatg
     2761 cttttgtgct tttggataca agattaaccc ttagaaattt tgaattttct atttgagata
     2821 taaaaagtca acaaaatata atatgttatt gatctatacc aagatagata gattgaagat
     2881 agaacgacag acagacagac agaagacagg tagacaacag acagatgaca gacagatctc
     2941 caaggtatgt tttccatttt cttttgttag agatgagctt gaatgtgatt atacgtaaat
     3001 ttgctaatac aataggataa tttataacac taatggccag atataagtgt aaacattttt
     3061 catacttgta tattttattt ttatctatat acaagaatga aatttcacaa ttttttaaac
     3121 aaattgtctt atatatgaag ccacagatta aattatgatt tatccttaat agcatctaaa
     3181 acattctaca aagttagtaa cgctgtcaga aaaaaaaaaa acaaaacaca aaaaaaaaaa
     3241 aaacagcaaa gggagtttga aaagcaagtt aaaaattggc cttctggtgt ggttcttatg
     3301 ggcatctgta agagcaaatt ctaactcctg tccaaatgac agagtggaat agtccttcgc
     3361 cagtgcaagg taaacattta cacaatccac tgttttaaca cctcactctt tggcaggatg
     3421 aaataataag tgaaaactaa aaatagcgct ctaaattttc atggtcattt tcaattttta
     3481 ctgaaacaaa ttcaaaagtc ttgttccccc aaattgcccc aatttcttca tcacttattg
     3541 gggtagtacc aagtaaggtg accagtattg ctcatcagat aggtttctaa gggaagtctg
     3601 agggagaatt agaaaggagt tttattctgc gtcatccact tcccttactc tatacgtgca
     3661 gagtggtgga ctctaccttg taatcaggag tcatgcgaag ccaagaaaag aaatagatta
     3721 tggtgcatag aaagtgatat tttgctatac aaatttgacc ttaattaaat tcatgagttg
     3781 taggcatttt taatttgttg tagatgatgg gccttgggtg acattaaagt cattatagct
     3841 atttgttgga tagtttttct gtttcgttgt gaatgctcag acagtattgt ctgagaaact
     3901 gcatctgagt gcatttaagt ataagcttaa tgcataaaaa gtcaacccca tcaatttcag
     3961 tatcaaacat tgttacagcc aaaacaagaa agacaagacc acacactgta taaagtccac
     4021 tgctctatag tttatgccaa gaccacaatc tttttaaccc aaagaaagtc tcttaattaa
     4081 ggtccaaggc tccaagaact gcacataagt tttagacata caagtgttta tttcaaagca
     4141 gactcagaga gcagagaagc tacaacatgg ctctagtgtt gtaatatttt ctatcagcac
     4201 actgacctat tctgaggggg ccatgttaat tttatatgat aaactccttc cgtagtactt
     4261 attatagtaa aataacatag aaaactgacc tatacgagtg ttaagaacct aatatggcag
     4321 atatgaaata tgtaaccagg aaaaactgtt aacattaaac atcacattta tgcaaattaa
     4381 atgcccttaa aattttgcca ttcgtctttc atttttaaag gttatttgcc ctcaattatg
     4441 taatttcagt gttataaagt ttagcttaaa ctactttgca ataatttatt tgacagatct
     4501 ccgttctata aaccatgcaa tgtaatgagg ccagagatct ttctttttta atgaaaacat
     4561 taacatgtta atatcccaca tgaatgatgc ttgacattca acgattgtcg aaatatgttg
     4621 gtatgttgct gaacatacac acacctctga aatgccagtt ctgcgttctg tgggctgatg
     4681 atctgactca tcgtgtgaca tatgctttct ggcagtgagt tcattgccag agtttaaaca
     4741 gggagttacg gtgctcatgg cgctttcaga acccaaagat ttgtggtttg gaatcatgta
     4801 gtctagtatg ctgcacttat ttttatattt ttaatgcact taattattgt ttttacaatt
     4861 atttgtacta actcagcatg taacaaccaa tttacatgga aataaattga aatatgataa
     4921 ctacaa
//
LOCUS       NM_001436624            4520 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 5,
            mRNA.
ACCESSION   NM_001436624 XM_039109388
VERSION     NM_001436624.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4520)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 4520)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 4520)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 4520)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 4520)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 4520)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039109388.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-4520           JAXUCZ010000005.1  6903961-6906241
FEATURES             Location/Qualifiers
     source          1..4520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4520
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423553.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..4520
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagt gaagtcataa caactagtgg agttgaaccc acagttctgc
     2281 cttggtgtct tcatcccttt aactgccaca ccccagtcag actcagacac aggcaaggag
     2341 gcttgaattg ggatgggatc acaagagaaa tgaaacttgg aaaattcagc cagaggacct
     2401 ttcaggttct tcaggaatgc tttgtgtctt tggggtcctc tgggagctga agcatacagc
     2461 catgttggaa agcagagctt aataatgatt cttttttaaa atctgctgaa gcagccccat
     2521 ccggcgaagt tcttggcgtt ggctactcca tctgtcctag cagagtgtga ctaaactgga
     2581 aatgtatgga cctgcaattt tttttttgat ggaagtcaac agctgcctta ctattttacc
     2641 atctgacgtt tttagtaggg agctgggttg agaagactgc cagaggaatg cagtctgagg
     2701 attgtgttgc agtgggcatg gcgccaacat tcactcctat ctcattagaa gaagtaggta
     2761 gcagcatcac tcagaggtct tctgctgtga cctactgctt taacatctcc tggaatgttc
     2821 tgaaagggaa tatttcattt gcttgtgcac aactctgctc atttttgctg tttatttaaa
     2881 tatgaccgca tagtcatctt ccactcgcaa tcctggctgg atgagaagac acaggttgca
     2941 tctcaaggaa aagcaacaac aaaagactag ttaaaaaata tatagtgttt attttaatag
     3001 caatacattg ttttcatgtt gtttattctt tttaaatcaa taaaagattt atttatcttt
     3061 aaaatatagt gatctgaagg tattatacct tccaaagaaa taatttaata ttaaatattt
     3121 ttaacaccat tgaggtgaat tgttgacgca ctcaggtgct acattttaca agctgaaaga
     3181 ctacatatta ccaagaagtg tagtcaaaat gttgcatgga tttcagtaat cagtggttaa
     3241 aggttcggtt tcattgctga cgtatgttac aaccaaataa aatcttgtca gtggctctgt
     3301 taattcccat gaaagttaag caagatctat taatagctac tcttctcttt ctctacccca
     3361 cccccagctc gaattttggt tgaatgcatt caggtagaca gtaaagtttt gttaagtcac
     3421 tgccccttct ctgccttcag tgtttttcaa agttgttttg taattctatt ttaaatttta
     3481 aagacttaga tggttttatt ttaaatattt gtcttttgct gtcctgtatc attctgatgt
     3541 tgattttttt tctattatat aatttactga gaagcatgct taactaggga aactacatga
     3601 tctttataaa aaaataatta tttaaaaaga aatcagtgta ggaaagatat gtctgaatct
     3661 cttaaaggca ttgccttgtg gagggggaag tcttcctaac ttttatccag gatatcatgg
     3721 tgtcagccga gtctcttact taggggcctt tgcagagaca gtgtgtgtca ctcccctgat
     3781 agcacaggag aggaccacat gcttcatcac ctacagggta gtaaaccagt ggtggtctct
     3841 ccagaagtgc aatatattga gactcttggg tatgaccaat atggattaaa gaagaaggca
     3901 gaaagagagc aaatgaaaat aaaattacaa cttgtatatt tattttttac attttgcttt
     3961 gactttaggg agtccatttt tactcaagaa caaactaagt ctgtctgtcg tctgcatagt
     4021 ctccctgcct gttcctaccc ttgaagctcc ttatgctggg aaggctgttt gtttgttttt
     4081 ttaagaaata gaatatttaa tctgaataag tgtttattta aatgtgtaat gctttgaaaa
     4141 taatgggcaa cagagaacta aaggatgttt ataaagtgag cttgttggct ccatttataa
     4201 atatatacga tttataagct tttttaaaac aaagctcaaa ttgtgggtat ttttctaaaa
     4261 tgtgcacagc tgtattttcc atgaaggatc tttctaatgg gttgttatac tgtactctac
     4321 attttggaca gcacatgaag tctgccaatg tacttaataa aacatgactt tgtttattta
     4381 aagtttcttg ctgtgaaaaa ccctaccagt gggttcctta atttataatc cttaaaacca
     4441 aaatgtataa tgtacagttt ccacaactgt aactgcccta ataaaaatgt tggttattaa
     4501 taaagttcga gatgtctttc
//
LOCUS       NM_001436607            5633 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 5, mRNA.
ACCESSION   NM_001436607 XM_008763607
VERSION     NM_001436607.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5633)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5633)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5633)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5633)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5633)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5633)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5633)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5633)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5633)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5633)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_008763607.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26911.1,
                                           SRR26360194.1011728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-230             JAXUCZ010000005.1  60609743-60609784   c
            231-497             JAXUCZ010000005.1  60609265-60609531   c
            498-557             JAXUCZ010000005.1  60607510-60607569   c
            558-784             JAXUCZ010000005.1  60605329-60605555   c
            785-888             JAXUCZ010000005.1  60599244-60599347   c
            889-5633            JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5633
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    108..110
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            189..230
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1043
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform b is encoded by transcript variant 5;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform b"
                     /protein_id="NP_001423536.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEVA
                     ESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKIS
                     MKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGE
                     KVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLES
                     QAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    <231..356
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    <231..356
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    504..809
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    504..809
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    order(786..788,792..794,798..806)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(786..788,792..794,798..806)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    792..794
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    792..794
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    861..1034
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    861..1034
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            231..497
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            498..557
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            558..784
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            785..888
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            889..5633
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagtt gaaagcggag tgtaacaaga gatatgtcaa cgttaagcag atgggggtca
      241 atcccaccag cattgacgaa gtcgtcattg ggaaggaccg ggagatgaag ctgctgcctg
      301 gtcaggttct ccacatggtg aatgaacttt atccatacat ggtggagttt gaggaggtgg
      361 cagagagccc taacgtaaca cagaggaaga gaaagaggcc agactgtgat agtcaggaga
      421 tggaagctga ggctggggcc agccccagcc agtgctctgt gtcccctaag acgggcaagc
      481 atggagccgc caaggaggaa tcactgggcc actggagtca aggcttgaag atatctatga
      541 aagaccccaa aatgcaggtt tataaggatg atcaggtggt ggtgattaag gataaatacc
      601 ccaaggcccg gcaccactgg ctggtcttac catgggcctc catttccagt ctgaaggttg
      661 tgaccagtga acacctcgaa cttctcaaac acatgcacgc agtaggggaa aaggtgatag
      721 cagattttac tggatccagc aaactgcgct tccgactggg ttaccatgcc attcccagca
      781 tgagccatgt acatcttcat gtgatcagcc aggattttga ttctccttgc cttaaaaaca
      841 aaaagcattg gaattctttc aatacagaat attttctgga gtcacaagct gtgatcaaga
      901 tggttcagga agctggcaga gtgactgtta aagatgggac ttgcgaactc ttgaagctgc
      961 ctctccgttg ccatgagtgt cagcagctgc tgccttccat cccacagctg aaggagcacc
     1021 tcaggaagca ctggggcggg tgacactcgc cttggtgacc gagtgcagtg ctagcatcat
     1081 tctgcattgc ctgcgctccg ttcagtcctg aactaaagca tgcagctctt caaaacaaag
     1141 cttattattc ttgagtgacc acacagggtg actctgggtc aggaactggg aatatgggtt
     1201 tgtatggtat attttctggt aatggaggat gagacatgcc tgatcactct tcccaagacc
     1261 atgtcaggcc tgactaataa gagggcagag ccagcttgag gttcaaatac aagatgtaga
     1321 agcagaggac tggtaatgta tttgttccta cccttgcccc tggatcatgt tctatctttt
     1381 tatcaagata gctgaggttc tgagggggcc tggttcctgc tctatgatat tcctcttccc
     1441 tccatgagga ggctttcaat ctactgtacc aggctgagtg cctgggtgaa catatgtggc
     1501 agtcatctgc acagagagat actttgtgta tgactgtgcc agggaactgg aagtggtaat
     1561 attgggcaca gtatgttaac agtacagcct gtgtcgaggg caaactgggg taatgtgaac
     1621 tgccagtaaa cagtacatcc tctgctgagg gcagcctggg gcagtgtgaa ctgccagtaa
     1681 acagtacagc ctgtgctgag ggcagcatgg aacagtgtga actgttagtg aacagtagtc
     1741 tgttctgagg gcagccttgt acagtgatgt cagttaacag tgcagtctgt tgagggcatc
     1801 ctgggatggt gtgaactgtc agttaacagt gcagtctgtt gagggcatcc tgggatggtg
     1861 tgaactgtca gttaacagtg cagtctgttg agggcatcct gggatggtgt gaactgtcag
     1921 ttaacagtgc agtctgttga gggcatcctg ggatggtgtg aactgtcagt taacagtgca
     1981 gtctgttgag ggcatcctgg gatggtgtga actgtcagtt aacagtgcag tctgtgttga
     2041 gggcagcctg ggcagtgtgt attgttagct tcaggcagat tttacggagg cttcagccac
     2101 tgctcttgag aattacagaa catttaacta aacttcggat aatgtatctt agaaaaacag
     2161 atgttgcaaa atagttcatt tactttccac ctgatacaat atagtttagc acatcagtat
     2221 taaaatgagt atttgctgta aactactagg agtgtctgta tcagacagcg taagaatgtc
     2281 aggtataatg agaaacattt ggggaatgag gtgaccatgc ttacattctt ccttctgccc
     2341 aaaatagatt tttttaagac tggggtgagt gcatgctgcc cttcctagga cctgagtttt
     2401 gttcccggca tccatattag gtggctcaca gctgcctgta gctccaggga tcctgcacct
     2461 gcttcttgac ctctgtgggc actgcattca agtacacaaa cctgaataca gacacacatt
     2521 cacacataat taaatctgta aaaatcagat ctcgggctgg agagatggct cagtggttaa
     2581 gagctcctcc agaggtcctg agttcaattc ccagcaacca catggtggct cacaaccatc
     2641 tgtaatggga tctgatgccc tcttctggta tgcatggaga cagccacagt gcacttatac
     2701 ataaataaat acataaataa aaaaaataga tctcttagag gaaaaatgtc aataatgact
     2761 ggcaggaagc aggtattgag gtattgaggt ttattcattc cctagccctc ctctccgaaa
     2821 tgggctttta tcaccatggg gaagaagact gtctggactc tggattactt gacagacatg
     2881 tcattgtaca attagttgaa gctttccttc agagtcagag ggagggatgt tgggagactg
     2941 caaagtagaa gaaagccagc cacatttaaa gctaggcaca gtggcaaatt ctcttgcaat
     3001 cccaaattta ggaggtggta gatccaggag ggccaggcat tccaggttat ccttgtctat
     3061 atggtgaact tgaggtctgg actacatgag accctatgtc acagaagcaa ataaataaaa
     3121 gatttaaaaa ggggaaataa aattctatct aaggtaccaa agcatattat ttggcccatc
     3181 atggccaggc aagaccagtt gttatcaaag cagctgttat ggctggaatc tgggataact
     3241 caggctcatg ttctggagcg tgggtccttt ccttgcagtg ttgtttagat gactgtgaag
     3301 ccattagggt gaagccgggc tggcagaagt aggtgtctag gagcaggcag gccctgaagg
     3361 ctataccctt tcccggctcc tggtgggctg ctttacctcc tgtgaacagg acacccatct
     3421 ctgctactat ggactgacac tgtgtgtgtg tgcgcgtgcg cacacgcgcg cgcgtgtgta
     3481 cacaagagga caatttctgg aagtcaattg tctccaccat attggcccta gggattgact
     3541 cactagcttg actcagtgtc tttacccact gagttccagt aagtcagaag tactctttta
     3601 agaaatagca acttagggcc tggagtgacg gctcaggggt taagagcact gactgctctt
     3661 ccagaggtcc tgagttcaat tcccagcaac cacatggtgg ctcacaacca tctgtaacag
     3721 gatccgattt acatataata aataaataaa tcttaaaaaa aagaaataac ttaattctca
     3781 agtacgtaca cacacacaca cacacacaca cacacacaca cacacacaca cactctctct
     3841 ctctctctcc taccttatcc caagctaccc taaactcacc atgtagacta ggatgacctt
     3901 gaacttgctg agatctgcca gtccagagcc agggtactgg gattcaagta tcccaccaaa
     3961 gaggaaaata agcaaatgta caaggattag atagacattg cccataatta attaaaattc
     4021 agtgttttct gagagtggaa atattgtcat gaaatattcc cttttgcagc aatgctcaga
     4081 tctgcctctt tagaatggtc tttctttttg aatgttgcta atggtgtact ggctggtttt
     4141 gtgtatcaat ttggcacacg ctagagtcat cagagaggaa ggaccttcag ttgagaaaat
     4201 gcctccatga gctccagctg taagacattt tcataattag ggatcagtgg ggctagcgcc
     4261 attgtgggtg gtaccactcc tggactggtg gtcctgggtc ctataagaag gcaggctgag
     4321 caagccaggg gaagcaagcc agtgtggggt gggggcaccc cactcatggt ctctgcctca
     4381 gctcctgtct ccaggttcct gctctgtctg agttcctgtc ctggctgcct ttggtggtga
     4441 acatgactgc tgtgtgattg cctgtctgtc actcgggctt tatggtatcc cagggcattc
     4501 agaattggga ggtgcataat ggagtgttat ttaagccata aataatgaac agaatggaat
     4561 tgtgtccttt gccagaagac agataccctg gaggtcatcc tgtgaaacgc aatcagccag
     4621 actcagaaca gtcacctcat actggtattt caaaggtctt ggctctcctg actctatgcc
     4681 catcgtgagg cagagcatag cagaggttga agcatgtaca aagccttctt ggcacatggg
     4741 acaaagaggc agagacacca ctttgttctg agattggtct tactgtgtag caaagactga
     4801 cctggaattc atgcagctca gtttggtctt gagttcaaga cccaactgcc ttagcagttc
     4861 tgggtgtgtg ctaggaagtg ttctcagata atgttttcag agcacgagac accttcatgt
     4921 gtaggctatc atgagtcaac taacctttct gtggctggac cctgcaggta aggggtggag
     4981 cgcagggcag aggagagact tctggcactc taaggagcct gtggaccacc tagattctta
     5041 cctgctgcta acatttccac accacaggca ccctctagcc tatggcagct gggaacttat
     5101 ttttgctttc aagaacccag tgataggtct gtttctcaaa tacagctgat gtggctgacc
     5161 ttgagtgaaa ggagactgaa ggttttagga gaccccagta tgtagacctg actgaacttg
     5221 cccctgaagc tgacagccca ttgcatactc ttcacatgaa tgagaaaaag gtgcctgttg
     5281 tatgtggagg cctttaaccc agatcccctg aggccggagc ccatgtgagg cacaactaca
     5341 tgaccacata gggtgatgtg atggtttgca tatttggccc agggagtggc actattagaa
     5401 ggtgtggcct tgttggagga agtgtgtcac tgtggggggg tgggcttgga gaccctcctc
     5461 ctagctgcct ggggatgctc agtctgttcc tggcttcctt tggttgaaga tgtagaactc
     5521 agctcctcct gcaccaggcc tgcctggatg ctgccatgct cctgccttga taatggacta
     5581 aacctctgat ctgtaagcca gccctaatta aatgttgtcc tttataaaac tta
//
LOCUS       NM_001436655            5018 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 7 (Slc26a7),
            transcript variant 3, mRNA.
ACCESSION   NM_001436655 XM_008763531
VERSION     NM_001436655.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Kiriya,M., Kawashima,A., Fujiwara,Y., Tanimura,Y., Yoshihara,A.,
            Nakamura,Y., Tanigawa,K., Kondo,T. and Suzuki,K.
  TITLE     Thyroglobulin regulates the expression and localization of the
            novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes
  JOURNAL   Endocr J 69 (10), 1217-1225 (2022)
   PUBMED   35644541
  REMARK    GeneRIF: Thyroglobulin regulates the expression and localization of
            the novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes.
REFERENCE   2  (bases 1 to 5018)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5018)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            acid challenge represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   4  (bases 1 to 5018)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   5  (bases 1 to 5018)
  AUTHORS   Kosiek,O., Busque,S.M., Foller,M., Shcheynikov,N., Kirchhoff,P.,
            Bleich,M., Muallem,S. and Geibel,J.P.
  TITLE     SLC26A7 can function as a chloride-loading mechanism in parietal
            cells
  JOURNAL   Pflugers Arch 454 (6), 989-998 (2007)
   PUBMED   17404755
  REMARK    GeneRIF: SLC26A7 is a Cl(-) uptake system under histamine
            stimulation
REFERENCE   6  (bases 1 to 5018)
  AUTHORS   Petrovic,S., Amlal,H., Sun,X., Karet,F., Barone,S. and Soleimani,M.
  TITLE     Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7
            in kidney medullary collecting ducts of Brattleboro rats
  JOURNAL   Am J Physiol Renal Physiol 290 (5), F1194-F1201 (2006)
   PUBMED   16352747
  REMARK    GeneRIF: vasopressin increases the expression of SLC26A7 protein
            through posttranscriptional mechanisms in the outer medullary
            collecting duct
REFERENCE   7  (bases 1 to 5018)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
REFERENCE   8  (bases 1 to 5018)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   9  (bases 1 to 5018)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 5018)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_008763531.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1648969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000005.1  32818836-32818928   c
            94-406              JAXUCZ010000005.1  32818355-32818667   c
            407-517             JAXUCZ010000005.1  32786927-32787037   c
            518-690             JAXUCZ010000005.1  32780136-32780308   c
            691-843             JAXUCZ010000005.1  32743404-32743556   c
            844-926             JAXUCZ010000005.1  32734765-32734847   c
            927-1074            JAXUCZ010000005.1  32732596-32732743   c
            1075-1188           JAXUCZ010000005.1  32730466-32730579   c
            1189-1266           JAXUCZ010000005.1  32721568-32721645   c
            1267-1362           JAXUCZ010000005.1  32720536-32720631   c
            1363-1469           JAXUCZ010000005.1  32712705-32712811   c
            1470-1536           JAXUCZ010000005.1  32704950-32705016   c
            1537-1674           JAXUCZ010000005.1  32701574-32701711   c
            1675-1723           JAXUCZ010000005.1  32698486-32698534   c
            1724-1824           JAXUCZ010000005.1  32689483-32689583   c
            1825-1879           JAXUCZ010000005.1  32685795-32685849   c
            1880-1983           JAXUCZ010000005.1  32685608-32685711   c
            1984-5018           JAXUCZ010000005.1  32681653-32684687   c
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5018
                     /gene="Slc26a7"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
     exon            1..93
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            94..406
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Slc26a7"
                     /note="upstream in-frame stop codon"
     CDS             214..2019
                     /gene="Slc26a7"
                     /note="isoform b is encoded by transcript variant 3; anion
                     exchange transporter; solute carrier family 26 (anion
                     exchanger), member 7"
                     /codon_start=1
                     /product="anion exchange transporter isoform b"
                     /protein_id="NP_001423584.1"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
                     /translation="MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLK
                     ENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG
                     TFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQI
                     YAYVFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFAC
                     YCTNMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSA
                     KKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF
                     VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIF
                     TICFAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKII
                     SINNPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQ
                     PCPSEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYG
                     DLDTEKPIFFDSVATAISVIQSNKNLSKDTDHSEV"
     misc_feature    310..1959
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    310..1959
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     exon            407..517
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            518..690
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            691..843
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            844..926
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1074
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1188
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1266
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1362
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1469
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1536
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1674
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1723
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1824
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1879
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1983
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..5018
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaccatct caccgccgaa cccattcctt ttccaagatc agaaaagtag tacatgaaca
       61 gggacccatt tcttattgag ataagaactc aagctttgac attgtaaacc acagacggat
      121 tggagcctgg catcgaaagg aggtgttctc caacgatttt tttctctctc ccttgcctga
      181 aaaagttgac tactacagga gggaatctga gaaatgacgg gggcaaagag gaaaaagaga
      241 agcgtgctgt ggggcaagat gcacaccccc caccgagaag acattaaaca gtggtgtaag
      301 aggcgcctac ctatcttgga atgggcaccg cagtacaatc tgaaggaaaa cctgcttcca
      361 gacaccgtgt ctggcgtact gttggcagtt caacaggtga cacaagggct gtccttcgct
      421 attctttcat ctgtacaccc agtttttggt ttatacggat ctctgtttcc tgccatcatt
      481 tatgcgatat ttggaatggg acgccatgtt gccacaggca cctttgcctt gacgtccttg
      541 atatcagcca atgctgtgga acggctggtc cctcagagca atagaaacct caccacacag
      601 agcaactcaa gcgtgctggg cttatcggag tttgagctgc agagaatcgg ggttgcagca
      661 gccgtttcat tcttgggcgg agtgattcag atctatgcgt atgtttttga gaacatcaag
      721 tctgtccagc tggaagcact gctcttgtcc ttgctgagca ttgttgtcct tgtcctcgtt
      781 aaagagctga acgagcagtt taagagaaag attaaagttg ttcttcctgt cgacttagtt
      841 ttgatcattg ctgcctcatt tgcttgctat tgtaccaaca tggaaaacac atacggatta
      901 gaagtagttg ggcgcattcc aaaagggatc cctccgcccc gtgctccccc aatgaacatc
      961 ctctccgcag tgctcacgga agctttcgga gttgcacttg taggctacgt ggcctcgctg
     1021 gctctcgcac aaggatctgc caagaagttc aaatattcag ttgatgacaa ccaggaattt
     1081 ttggcccatg gcctcagcaa cgtgattcct tcatttctct tctgcatccc aagcgccgcc
     1141 gccatgggaa ggacagctgg tctgtacagc acgggggcaa agacacaggt ggcttgtcta
     1201 atatcttgca ttttcgtcct tatagtcatc tatgcaatag gacccttgct gtactggctg
     1261 cccatgtgcg ttcttgcaag tattattgtt gtgggactga aaggaatgtt aatacagttc
     1321 cgggatttaa aaaaatactg gaatgtggat aaaatcgatt ggggcatatg gatcagcact
     1381 tacattttta caatatgctt cgctgccaac gtgggactgc tctttggtgt tgtctgcacc
     1441 atagctatcg tgttagggcg tttcccaagg gcaaagactt taagcataac agacatgaaa
     1501 gaaatggaat tgaaggtgaa gacagaaacg tatgatgaaa actcgcaaca gataaaaatc
     1561 atctcaataa acaacccact tgttttcctg aatgcaaaga aatttagtgc tgatcttatg
     1621 aaaataatcc taaaggaaac tgacggcagc caagcacttg atgatgtcag caagtgtgaa
     1681 cagaacacct tgctcagtcc cctgcccaac gggagctgca ctgaagaagc ctcccagccc
     1741 tgccccagtg agaagtattc tttggtcctg aattgcagtg gcttgacctt tttcgactac
     1801 acaggagtct ccacacttgt tgagctctac cttgattgca agagcaggag tgtggatgtg
     1861 ttcttagcca actgtacagc atccttgata aaagcgatga catactatgg agacctagac
     1921 actgaaaaac caattttttt tgactcggta gccactgcaa taagtgtcat ccaatcaaat
     1981 aagaatttga gcaaggacac tgaccacagt gaagtctgag gtccacgcat tgaaatgcac
     2041 atctcatctt tagcacctgc cccaaagagg ccagatactg gcattttgca ctcattttgg
     2101 tgtatatact gtatatctct taattagaat gatgtgagtt ggcaactgga tagccactgg
     2161 ccaagacttg ctgacatcct attttttcta atttttctta ataaacagat tcattagtta
     2221 tttcatatag gcatcaatat gcatgtagct ttagtttaat gaacagtaaa catgctttta
     2281 tttccagtta taagagtatt ttgtatggtt tcatttttgt tgtaagctaa caaatggaga
     2341 aatattttta tcagaaatgg tttggattat ttataaacca ttcataaaaa aattaagatc
     2401 atctagtaca taaaaaagta ttaacaaatg tgccatttct ccatagtttt tatcccaaaa
     2461 ttatttgaac atcagttaga taaagtatca cttttataca gggaaaatga aatccataga
     2521 tataaaacaa gtgagaaaga gacaaattag aagttattaa tgtcaatgcc catcaacaca
     2581 ctcactctga caatattcat atattcaatt atgagttcat atttggaaga aaactaatgt
     2641 tttagcaaaa ctaagttctt gatgtttatc tgctgaattg tggatactgg agaccatttg
     2701 tgtgtttaat cagataactc tgacttctgc attgcaacac ataagatatt ctgctttcaa
     2761 acttctttct tgcaatcaga gaatatgaga atttgatatg tattttttca aaaatatgca
     2821 tttttcaatg ataaaatatc ataagtagaa tgcttttgtg cttttggata caagattaac
     2881 ccttagaaat tttgaatttt ctatttgaga tataaaaagt caacaaaata taatatgtta
     2941 ttgatctata ccaagataga tagattgaag atagaacgac agacagacag acagaagaca
     3001 ggtagacaac agacagatga cagacagatc tccaaggtat gttttccatt ttcttttgtt
     3061 agagatgagc ttgaatgtga ttatacgtaa atttgctaat acaataggat aatttataac
     3121 actaatggcc agatataagt gtaaacattt ttcatacttg tatattttat ttttatctat
     3181 atacaagaat gaaatttcac aattttttaa acaaattgtc ttatatatga agccacagat
     3241 taaattatga tttatcctta atagcatcta aaacattcta caaagttagt aacgctgtca
     3301 gaaaaaaaaa aaacaaaaca caaaaaaaaa aaaaacagca aagggagttt gaaaagcaag
     3361 ttaaaaattg gccttctggt gtggttctta tgggcatctg taagagcaaa ttctaactcc
     3421 tgtccaaatg acagagtgga atagtccttc gccagtgcaa ggtaaacatt tacacaatcc
     3481 actgttttaa cacctcactc tttggcagga tgaaataata agtgaaaact aaaaatagcg
     3541 ctctaaattt tcatggtcat tttcaatttt tactgaaaca aattcaaaag tcttgttccc
     3601 ccaaattgcc ccaatttctt catcacttat tggggtagta ccaagtaagg tgaccagtat
     3661 tgctcatcag ataggtttct aagggaagtc tgagggagaa ttagaaagga gttttattct
     3721 gcgtcatcca cttcccttac tctatacgtg cagagtggtg gactctacct tgtaatcagg
     3781 agtcatgcga agccaagaaa agaaatagat tatggtgcat agaaagtgat attttgctat
     3841 acaaatttga ccttaattaa attcatgagt tgtaggcatt tttaatttgt tgtagatgat
     3901 gggccttggg tgacattaaa gtcattatag ctatttgttg gatagttttt ctgtttcgtt
     3961 gtgaatgctc agacagtatt gtctgagaaa ctgcatctga gtgcatttaa gtataagctt
     4021 aatgcataaa aagtcaaccc catcaatttc agtatcaaac attgttacag ccaaaacaag
     4081 aaagacaaga ccacacactg tataaagtcc actgctctat agtttatgcc aagaccacaa
     4141 tctttttaac ccaaagaaag tctcttaatt aaggtccaag gctccaagaa ctgcacataa
     4201 gttttagaca tacaagtgtt tatttcaaag cagactcaga gagcagagaa gctacaacat
     4261 ggctctagtg ttgtaatatt ttctatcagc acactgacct attctgaggg ggccatgtta
     4321 attttatatg ataaactcct tccgtagtac ttattatagt aaaataacat agaaaactga
     4381 cctatacgag tgttaagaac ctaatatggc agatatgaaa tatgtaacca ggaaaaactg
     4441 ttaacattaa acatcacatt tatgcaaatt aaatgccctt aaaattttgc cattcgtctt
     4501 tcatttttaa aggttatttg ccctcaatta tgtaatttca gtgttataaa gtttagctta
     4561 aactactttg caataattta tttgacagat ctccgttcta taaaccatgc aatgtaatga
     4621 ggccagagat ctttcttttt taatgaaaac attaacatgt taatatccca catgaatgat
     4681 gcttgacatt caacgattgt cgaaatatgt tggtatgttg ctgaacatac acacacctct
     4741 gaaatgccag ttctgcgttc tgtgggctga tgatctgact catcgtgtga catatgcttt
     4801 ctggcagtga gttcattgcc agagtttaaa cagggagtta cggtgctcat ggcgctttca
     4861 gaacccaaag atttgtggtt tggaatcatg tagtctagta tgctgcactt atttttatat
     4921 ttttaatgca cttaattatt gtttttacaa ttatttgtac taactcagca tgtaacaacc
     4981 aatttacatg gaaataaatt gaaatatgat aactacaa
//
LOCUS       NM_001436642            6429 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus PLAG1 zinc finger (Plag1), transcript variant 4,
            mRNA.
ACCESSION   NM_001436642 XM_017593224
VERSION     NM_001436642.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6429)
  AUTHORS   Gu,Q. and Wei,H.F.
  TITLE     PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of
            Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin
            Signalling Pathway
  JOURNAL   Folia Biol (Praha) 68 (1), 25-32 (2022)
   PUBMED   36201855
  REMARK    GeneRIF: PLAG1 Promotes High Glucose-Induced Angiogenesis and
            Migration of Retinal Endothelial Cells by Regulating the
            Wnt/beta-Catenin Signalling Pathway.
REFERENCE   2  (bases 1 to 6429)
  AUTHORS   Hide,T., Takezaki,T., Nakatani,Y., Nakamura,H., Kuratsu,J. and
            Kondo,T.
  TITLE     Sox11 prevents tumorigenesis of glioma-initiating cells by inducing
            neuronal differentiation
  JOURNAL   Cancer Res 69 (20), 7953-7959 (2009)
   PUBMED   19808959
REFERENCE   3  (bases 1 to 6429)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
REFERENCE   4  (bases 1 to 6429)
  AUTHORS   Voz,M.L., Agten,N.S., Van de Ven,W.J. and Kas,K.
  TITLE     PLAG1, the main translocation target in pleomorphic adenoma of the
            salivary glands, is a positive regulator of IGF-II
  JOURNAL   Cancer Res 60 (1), 106-113 (2000)
   PUBMED   10646861
REFERENCE   5  (bases 1 to 6429)
  AUTHORS   Astrom,A.K., Voz,M.L., Kas,K., Roijer,E., Wedell,B., Mandahl,N.,
            Van de Ven,W., Mark,J. and Stenman,G.
  TITLE     Conserved mechanism of PLAG1 activation in salivary gland tumors
            with and without chromosome 8q12 abnormalities: identification of
            SII as a new fusion partner gene
  JOURNAL   Cancer Res 59 (4), 918-923 (1999)
   PUBMED   10029085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_017593224.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.128547.1,
                                           SRR26360172.872299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  21754093-21754272   c
            181-285             JAXUCZ010000005.1  21718307-21718411   c
            286-385             JAXUCZ010000005.1  21710736-21710835   c
            386-6429            JAXUCZ010000005.1  21699650-21705693   c
FEATURES             Location/Qualifiers
     source          1..6429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..6429
                     /gene="Plag1"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
     exon            1..180
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..285
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..385
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    360..362
                     /gene="Plag1"
                     /note="upstream in-frame stop codon"
     exon            386..6429
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1643
                     /gene="Plag1"
                     /note="isoform b is encoded by transcript variant 4; zinc
                     finger protein PLAG1; pleiomorphic adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1 isoform b"
                     /protein_id="NP_001423571.1"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
                     /translation="MATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEEC
                     GKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKK
                     HQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLK
                     VKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQS
                     SGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKCPFSSTSYAISIPEKEQPLKGEIES
                     YLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDDGAGDLSLSKSSISISDPLNTPALD
                     FSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHSSVSQLPTQTQDLQDPANTVGLGSL
                     HSLSAAFTSSLSSSTTLPRFHQAFQ"
     misc_feature    417..>563
                     /gene="Plag1"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; Region: SUF4-like;
                     cd20908"
                     /db_xref="CDD:411020"
     misc_feature    417..>563
                     /gene="Plag1"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; Region: SUF4-like;
                     cd20908"
                     /db_xref="CDD:411020"
     misc_feature    423..503
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:411020"
     misc_feature    423..503
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:411020"
     misc_feature    423..485
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    423..485
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(438..440,468..470,489..491,495..497,507..509,
                     528..530)
                     /gene="Plag1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:411020"
     misc_feature    order(438..440,468..470,489..491,495..497,507..509,
                     528..530)
                     /gene="Plag1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:411020"
     misc_feature    510..572
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    510..572
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    510..563
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:411020"
     misc_feature    510..563
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:411020"
     misc_feature    597..659
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    597..659
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(597..599,606..608,645..647,657..659)
                     /gene="Plag1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(597..599,606..608,645..647,657..659)
                     /gene="Plag1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(612..614,618..620,624..626,630..635,642..647,
                     654..656,717..719,723..725,735..740,747..752,759..761,
                     801..803,807..809,813..815,819..824,831..836)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(612..614,618..620,624..626,630..635,642..647,
                     654..656,717..719,723..725,735..740,747..752,759..761,
                     801..803,807..809,813..815,819..824,831..836)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    702..764
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    702..764
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    786..842
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    786..842
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
ORIGIN      
        1 agctgcaagt tgagctgcag gggcagcgca tacactacaa tggctgctgg aaagaggcgt
       61 aaggaaacaa tttccaggcc cgccgcgtcc agcccgaaat atgagaaaaa aattattaga
      121 aattccgcgg gcggtgtaaa ggcggcggac gggccggagg gaggatgtta aagccccgcg
      181 gttgcctctc agtgctgcct tggtggtatt gggcacccag aatgcttcag tctgtaatga
      241 tctattaata aggtggccta actagagttt gcagcagggt ctcagattgg ccaaaatggg
      301 aagggatgga ttctgctctc ttccacgaag agttaatggg actggctaag atcaaagtct
      361 gaggcttttt tccatcacta atcaggcaca tggctactca ctctcctgag aaaacccaca
      421 agtgtaatta ttgtgagaaa atgtttcacc ggaaagacca tctgaagaac cacctccata
      481 cacacgaccc caacaaagag acttttaaat gcgaagagtg tggcaagagc tacaacacca
      541 agcttgggtt taagcgacac ttggccttgc acgctgccac cagtggcgac ctcacctgca
      601 aggtgtgttt gcagactttt gagagcacag gtgtgctcct agagcacctg aaatctcacg
      661 caggcaagtc ctctgggggc gtgaaagaga aaaagcacca gtgtgagcac tgcgagcgca
      721 ggttctacac ccggaaggat gttcggagac acatggtggt gcacacggga agaaaggact
      781 tcctctgtca gtactgtgca cagagatttg gacgaaagga tcacctcact cgacacatga
      841 agaagagtca caatcaagag cttctgaagg tcaaaactga accagtcgat ttcctggacc
      901 cattcacctg caacatgtct gtgcctataa aagatgagct cctgccggtc atgtccttgc
      961 cttccagcga actcttgtca aagccattca ccaacacttt gcagttaaac ctctataaca
     1021 ctccatttca gtccatgcag agctctgggt ctactcacca aatgataaca actttacctt
     1081 tgggaatgac gtgccccata gatatggaca ctgttcaccc ctctcatcat cttgctttca
     1141 aatgcccgtt cagttctacc tcatacgcaa tctctattcc cgagaaagaa cagcccttaa
     1201 agggggaaat cgagagttat ctgatggagt tacaaggtgg cgcaccatct tcatcccagg
     1261 attctcaagc atcatcgtct aagttagggt tagagcctca gagtggctcc ccagacgatg
     1321 gtgctgggga cctctccctg tcaaagagct ctatctctat cagtgacccc ctgaacacac
     1381 cagcattgga tttctctcag ttgttcaatt tcataccatt aaatggtcct ccttacaatc
     1441 cgctctccgt gggaagcctt gggatgagct attcccagga cgaggcgcat tcttctgttt
     1501 ctcagctgcc cacacaaaca caggatcttc aggatcctgc gaacacagtg ggccttggct
     1561 ctctgcactc actgtcagca gctttcacca gcagcctaag ctcaagcact accctgcccc
     1621 gtttccacca ggcctttcag tagggtctgg gccgagggat tcaccggagg tgcttgtgca
     1681 gccccgcctg caaagaccat ttatattcta gtgcctactt taacacaaca cagaaacttc
     1741 tccttttgta taatatcagg ttttatgaag ccagtaaata ggaattagcc tctttgataa
     1801 gctttgaaat ggttcgtgtt taactacgtt tgctgtttct cctgatttcc tgccagttgt
     1861 catagtctcg gagttttatt tcatagagga gcgccattat tatcactaaa ttttacaagt
     1921 cctgtgttca aattactgtt agaccttaac attctcactt ttgtctaata gcaatgggca
     1981 ttggactttt ttttttttgc aaatgtgcag tacaatgtaa atcttctatg aaatgtgtgt
     2041 gaagaactga agtgtttcac atttctttac tagccactaa atggattcat aatcaagtgt
     2101 gttttaaatg agttaagaat ccagtttggg gagagtatag tggtttccta aatacaccat
     2161 catttgagat caatatattt tgaagactgc tattgtctgg ctaaaataag aagtttcagt
     2221 atctatttaa tagaaaccta gagatgttac ggggtgttct gtgttagaac tagccctcag
     2281 gctgatttgc cacatttcaa ccatctttcc gttaacagtg tgtggcctcg gagtcttcag
     2341 gatcagtgta gaagtgttct gttgtatgcc cttcaccttt cataccccag gatggcttca
     2401 caataccagc attcttactt tgcatgttgg tccagttagt gcagagtctt agaaccattg
     2461 tgggacaata gacagtaaat atatgaagcc cagagtggct ggctgcctga atcgtcgggg
     2521 tgatagactc ctcaccagga agatggatgt aaaacgtaca gccaaacccc agcacttgtc
     2581 tagagaatgt ccactgttgc cagaactgag aactggactc ctatcgcatc acttctaaaa
     2641 cagcagtctt gcccgtgcgc ccttgctcag tgcatataca tctttccctg ccgtgtttgg
     2701 atggagaact taaaaattaa acacatcaaa aagcaacttg acgagttcca cagttttaca
     2761 ccaccaaaag ttgttaagag cccactttta cacatctcca ggagacagga ggaatgttag
     2821 aaataagttg aatttataga ggaaacagag gaaaataaag caaacaccaa atgaatacga
     2881 atgcaccaag gatgtggtgc tcactgagca aggtagcaat gggcttcctc ttgtcagaca
     2941 gccaccaaga atgtcatcgg tagctccgcg tatatcttcc taagggttat ttgtggcatc
     3001 aacctacgag acttactaag cacttgttaa caccttattc tggacccctt ctgttggggc
     3061 agggagtttt atagaagagt atatatctct ttaaaaaaaa aaaaaaggaa gaaactattt
     3121 tttaatctct gagcactcgt tagccctggc tggggaagct tcttcccttg tgtaagggcc
     3181 agttatcact gcatattgta ttgtttaccc atcactctaa gcataaacag attactgact
     3241 atgatgcatt atttacaatg cctgggagta gtctaaattg agaagtgtaa actgtcctgt
     3301 gaatggggct ttcactatat gtcatacaca cgcctagtgc acttcataga atcagagctg
     3361 ctccctagag ggctcaagct cctggttcta accctagagc agtagttttt atacgtatgt
     3421 atttaaattt tattgtgaaa aatacatttt attaaagaaa gtgttccaaa ggcattaaaa
     3481 ttatatacgt taataaggaa atacatttta actcttcaag ctgctcctga gctgagggtg
     3541 ggagcgcact cactcagaaa gtgggctctt cgcatgaccg cttccttagt ttctatgaaa
     3601 ccgatcacgt accctaatgt tctagttgga tgattagtgt tcaatattgc tttaatcacc
     3661 acttttaaaa ggagaggaca tttggtgaca gagcacaagt aaataaaaaa acctattatt
     3721 atgtagagtt cacagacacc acatatgaaa gcactagttt attctatcta aaaattactt
     3781 aagaagtcac atttatgacc tgagacgttg gccttcgtag gctgtatata tttcactgct
     3841 aattgaaaaa agggagtacc aggatatatg aaataaagca tttcgcaatg ggaatggcgc
     3901 catatatgtg tgtgtgtgta tatatatata tatatgtatg tatatatata tatataataa
     3961 atatattttt atcctaattc ttgcccagcg cagaactcta atacacatct tccagggtac
     4021 cagtgttaaa acgtagagtc ttactttcct ttgtatgtac acctctttgc ctgttgctgc
     4081 ccccacagac ttgaatgaca tttcaaagta agagggaaat aagcaaattc ttttcgcttt
     4141 attgactgca gtggtcacta aacccttttt tgatagattt tatattaaaa atcagtcagc
     4201 ttttttattt tcattgcaca atgttttaac aggaacgcaa cacagaattg gcaaccccta
     4261 ccccatggaa aatactgtca ctcgttctgt ctgaagtagg actgcttagc aataggcctt
     4321 gctagtgccc ttctcattct ccatggtcct cgggatttct gatagtgcct tagcttaaaa
     4381 gaaaaggggt taacattaac taaacagtgt agtgtagagt ttggacctca gacaagatgc
     4441 tgggccccgt tcattttgac ttccacacat gtgtgtgcag cttcaggagt gtgagcgcct
     4501 tttcaggaaa ggtctggcac tgtgagcaat atagtccatt gatatttacc aataaatacc
     4561 acctctgtag ttaatgtctc ttaagcttcc gtttaaaatc ccgttacttg ttgaggtttc
     4621 taaaatgtaa gttgccttgg cagatcatgc accagtctgt gtgcagcttt tttccctttt
     4681 taatttcagt tggcgtttct ttcaagctgt gtgtgtttgc ctatgtgtcg cttgcgcttt
     4741 atttttctag tcatttgtgg aatatagtga tatattgtgt taatttggac agtgacggtt
     4801 ttttgaaacc atatactgac tgaaacatga gccagagctg attgctttat taagctaata
     4861 atgaatgtta tagagtacat atttcaggat cattcatcta gtgagcagta cacatatagg
     4921 ccaattaaaa aaaaatagag cttggtcaac ctctatactt cacatactac aagatatagc
     4981 actttcaaaa tgaacctaaa tttctacaga aactttccta tatgttatgc cttttatttt
     5041 taagacttat tatattcatt tcaagtgcca ttagacgata tatccgtagg cctttgatat
     5101 ataatgcttt gtgtacaaag aatagtagat ggtattttaa acaggtacat ttttacagtg
     5161 ttttcctatc gatttgctat attgcacaga atcagtgtgt gtcctttcat aaggttttac
     5221 aatggtttat ttttttacaa ggtttacgta tctcaaagca cactgtcttc ccagtccata
     5281 agtaagttaa aagataccag ttcacccaag ttgcttctag cctactgcga tccatgtgac
     5341 attgaaggag atctttgcag tgttgaatat tcgcccttca tgaaggcagg ctggtttttt
     5401 ttcctgacaa atgagttcgt tggtgaattt gtctcgtttt actcatgatg tcagcagccg
     5461 ggtctaccac acaacatagc ttgattgtgt aagcctccgt aaatacctta aattgtattg
     5521 tacccacaga gcactcctct gagattaagc aagctaatgc catcagcctt catagcaggc
     5581 acggatcacc aataagcctt tctacaatgt tagcagcccc tggagatgga aggcagtgtc
     5641 ttttgataag ttatctatct ctatagatga cacaggatta ttactgatgt ataagacact
     5701 tcattgtata agcttcagtg gtacagatga accagaatga atgtctgtct tctcagaagc
     5761 cctccttcaa cgttctatgg gatcatgctg ctactgtcac ttgggataca actcttcatg
     5821 gtgctacaaa cttctgtctc attcacttgt atttttttac ccataggaaa aggactctat
     5881 aggtgtaaag gtgtacaata tatttttata ctgtgactta aattgtcatt aacaaacttt
     5941 tacaccacca cagtgtactc atgtgcgctt gcaaaaggag atcttggatg tgcaaatgtt
     6001 accagaacaa acccagcttt tgtccacaag gtgactgtaa ctcagaatgg aaagtgagct
     6061 tgacataggg tgtggagtga agaacatgct ataagttact aacagccctt tgaatttaac
     6121 aaaaactggg aatccattag agaaatggat tgcatcatgc ctgaacataa gctgactgct
     6181 gaaatatttt tttttagcta atgaaaaagt gtttggacta gtgtactcta aaaaatgttt
     6241 taatggtaaa gttttgagtc aaatagaaat gaaaaaaaat ctgcattcca gacttaattt
     6301 tgtatatttt tattgccttt taaattgcta ttctgtgata ttgggaaatc aagtggctta
     6361 tcatgtatat catgtactta aaatgtattc acaaactact gttgtatttg tataaaatat
     6421 agacaaaga
//
LOCUS       NM_001436623            4248 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 4,
            mRNA.
ACCESSION   NM_001436623 XM_006237721
VERSION     NM_001436623.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4248)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 4248)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 4248)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 4248)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 4248)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 4248)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237721.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-4248           JAXUCZ010000005.1  6904233-6906241
FEATURES             Location/Qualifiers
     source          1..4248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4248
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423552.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..4248
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagc agccccatcc ggcgaagttc ttggcgttgg ctactccatc
     2281 tgtcctagca gagtgtgact aaactggaaa tgtatggacc tgcaattttt tttttgatgg
     2341 aagtcaacag ctgccttact attttaccat ctgacgtttt tagtagggag ctgggttgag
     2401 aagactgcca gaggaatgca gtctgaggat tgtgttgcag tgggcatggc gccaacattc
     2461 actcctatct cattagaaga agtaggtagc agcatcactc agaggtcttc tgctgtgacc
     2521 tactgcttta acatctcctg gaatgttctg aaagggaata tttcatttgc ttgtgcacaa
     2581 ctctgctcat ttttgctgtt tatttaaata tgaccgcata gtcatcttcc actcgcaatc
     2641 ctggctggat gagaagacac aggttgcatc tcaaggaaaa gcaacaacaa aagactagtt
     2701 aaaaaatata tagtgtttat tttaatagca atacattgtt ttcatgttgt ttattctttt
     2761 taaatcaata aaagatttat ttatctttaa aatatagtga tctgaaggta ttataccttc
     2821 caaagaaata atttaatatt aaatattttt aacaccattg aggtgaattg ttgacgcact
     2881 caggtgctac attttacaag ctgaaagact acatattacc aagaagtgta gtcaaaatgt
     2941 tgcatggatt tcagtaatca gtggttaaag gttcggtttc attgctgacg tatgttacaa
     3001 ccaaataaaa tcttgtcagt ggctctgtta attcccatga aagttaagca agatctatta
     3061 atagctactc ttctctttct ctaccccacc cccagctcga attttggttg aatgcattca
     3121 ggtagacagt aaagttttgt taagtcactg ccccttctct gccttcagtg tttttcaaag
     3181 ttgttttgta attctatttt aaattttaaa gacttagatg gttttatttt aaatatttgt
     3241 cttttgctgt cctgtatcat tctgatgttg attttttttc tattatataa tttactgaga
     3301 agcatgctta actagggaaa ctacatgatc tttataaaaa aataattatt taaaaagaaa
     3361 tcagtgtagg aaagatatgt ctgaatctct taaaggcatt gccttgtgga gggggaagtc
     3421 ttcctaactt ttatccagga tatcatggtg tcagccgagt ctcttactta ggggcctttg
     3481 cagagacagt gtgtgtcact cccctgatag cacaggagag gaccacatgc ttcatcacct
     3541 acagggtagt aaaccagtgg tggtctctcc agaagtgcaa tatattgaga ctcttgggta
     3601 tgaccaatat ggattaaaga agaaggcaga aagagagcaa atgaaaataa aattacaact
     3661 tgtatattta ttttttacat tttgctttga ctttagggag tccattttta ctcaagaaca
     3721 aactaagtct gtctgtcgtc tgcatagtct ccctgcctgt tcctaccctt gaagctcctt
     3781 atgctgggaa ggctgtttgt ttgttttttt aagaaataga atatttaatc tgaataagtg
     3841 tttatttaaa tgtgtaatgc tttgaaaata atgggcaaca gagaactaaa ggatgtttat
     3901 aaagtgagct tgttggctcc atttataaat atatacgatt tataagcttt tttaaaacaa
     3961 agctcaaatt gtgggtattt ttctaaaatg tgcacagctg tattttccat gaaggatctt
     4021 tctaatgggt tgttatactg tactctacat tttggacagc acatgaagtc tgccaatgta
     4081 cttaataaaa catgactttg tttatttaaa gtttcttgct gtgaaaaacc ctaccagtgg
     4141 gttccttaat ttataatcct taaaaccaaa atgtataatg tacagtttcc acaactgtaa
     4201 ctgccctaat aaaaatgttg gttattaata aagttcgaga tgtctttc
//
LOCUS       NM_001008316            6670 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus PLAG1 zinc finger (Plag1), transcript variant 2,
            mRNA.
ACCESSION   NM_001008316 XM_232651
VERSION     NM_001008316.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6670)
  AUTHORS   Gu,Q. and Wei,H.F.
  TITLE     PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of
            Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin
            Signalling Pathway
  JOURNAL   Folia Biol (Praha) 68 (1), 25-32 (2022)
   PUBMED   36201855
  REMARK    GeneRIF: PLAG1 Promotes High Glucose-Induced Angiogenesis and
            Migration of Retinal Endothelial Cells by Regulating the
            Wnt/beta-Catenin Signalling Pathway.
REFERENCE   2  (bases 1 to 6670)
  AUTHORS   Hide,T., Takezaki,T., Nakatani,Y., Nakamura,H., Kuratsu,J. and
            Kondo,T.
  TITLE     Sox11 prevents tumorigenesis of glioma-initiating cells by inducing
            neuronal differentiation
  JOURNAL   Cancer Res 69 (20), 7953-7959 (2009)
   PUBMED   19808959
REFERENCE   3  (bases 1 to 6670)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
REFERENCE   4  (bases 1 to 6670)
  AUTHORS   Voz,M.L., Agten,N.S., Van de Ven,W.J. and Kas,K.
  TITLE     PLAG1, the main translocation target in pleomorphic adenoma of the
            salivary glands, is a positive regulator of IGF-II
  JOURNAL   Cancer Res 60 (1), 106-113 (2000)
   PUBMED   10646861
REFERENCE   5  (bases 1 to 6670)
  AUTHORS   Astrom,A.K., Voz,M.L., Kas,K., Roijer,E., Wedell,B., Mandahl,N.,
            Van de Ven,W., Mark,J. and Stenman,G.
  TITLE     Conserved mechanism of PLAG1 activation in salivary gland tumors
            with and without chromosome 8q12 abnormalities: identification of
            SII as a new fusion partner gene
  JOURNAL   Cancer Res 59 (4), 918-923 (1999)
   PUBMED   10029085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_001008316.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085871.1, CK601489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000005.1  21711074-21711240   c
            168-267             JAXUCZ010000005.1  21710736-21710835   c
            268-626             JAXUCZ010000005.1  21706208-21706566   c
            627-6670            JAXUCZ010000005.1  21699650-21705693   c
FEATURES             Location/Qualifiers
     source          1..6670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..6670
                     /gene="Plag1"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
     exon            1..167
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..267
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..626
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    376..378
                     /gene="Plag1"
                     /note="upstream in-frame stop codon"
     CDS             385..1884
                     /gene="Plag1"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein PLAG1; pleiomorphic adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1 isoform a"
                     /protein_id="NP_001008317.1"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
                     /translation="MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFN
                     SVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKC
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDD
                     GAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHS
                     SVSQLPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ"
     misc_feature    385..483
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    388..636
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Interaction with KPNA2. /evidence=ECO:0000250"
     misc_feature    448..459
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    490..552
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    490..552
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    505..1110
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Decreased nuclear import with localization in the
                     nucleus but also in the cytoplasm. /evidence=ECO:0000250"
     misc_feature    order(505..507,511..513,517..519,523..528,535..540,
                     547..549,595..597,601..603,613..618,625..630,637..639,
                     679..681,685..687,691..693,697..702,709..714,721..723)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(505..507,511..513,517..519,523..528,535..540,
                     547..549,595..597,601..603,613..618,625..630,637..639,
                     679..681,685..687,691..693,697..702,709..714,721..723)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    <556..801
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <556..801
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    574..642
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    574..642
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    619..687
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    619..687
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    664..726
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    664..726
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    751..813
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    751..813
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    838..900
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    838..900
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(853..855,859..861,865..867,871..876,883..888,
                     895..897,958..960,964..966,976..981,988..993,1000..1002,
                     1042..1044,1048..1050,1054..1056,1060..1065,1072..1077)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(853..855,859..861,865..867,871..876,883..888,
                     895..897,958..960,964..966,976..981,988..993,1000..1002,
                     1042..1044,1048..1050,1054..1056,1060..1065,1072..1077)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    943..1005
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    943..1005
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1027..1083
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1027..1083
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1111..1881
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Activates transcription, Inhibition of nuclear
                     import due to lack of NLS and KPNA2 interaction.
                     /evidence=ECO:0000250"
     misc_feature    1111..1533
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Repression domain, contains 3 sumoylation motifs
                     and massively decrease transcription activity.
                     /evidence=ECO:0000250"
     misc_feature    1474..1584
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1534..1881
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Massively activates transcription.
                     /evidence=ECO:0000250"
     exon            627..6670
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtggca gtgtgggtgg cagtactgta atcaggagga aactgagttc tattaagctc
       61 aatgaatttt tatctgtttt gtttacagtc cgtaactctt gcttagattt cttttttatt
      121 aacaagtggg gagccattca gcatcacaaa ttgacatttt tttctagatt ggccaaaatg
      181 ggaagggatg gattctgctc tcttccacga agagttaatg ggactggcta agatcaaagt
      241 ctgaggcttt tttccatcac taatcagtcc ctttttgctt tcttttacga ccacatgaaa
      301 cttgagaagc cacctaaagc taaatcactt agtggagttg ggcagttccc aggtgtccaa
      361 cgagaaggcc tggtttaggc tgcgatggcc actgtcattc ctggtgattt gtcagaagta
      421 agagataccc agaaagcccc ttcagggaaa cgtaagcgtg gtgaaagcaa accaagaaaa
      481 aactttcctt gccaactgtg tgacaaggcc tttaacagtg ttgagaaatt aaaggttcac
      541 tccttctctc acacgggaga gaggccctac aagtgcacac accaagactg caccaaggcc
      601 tttgtttcta agtacaaatt acaaaggcac atggctactc actctcctga gaaaacccac
      661 aagtgtaatt attgtgagaa aatgtttcac cggaaagacc atctgaagaa ccacctccat
      721 acacacgacc ccaacaaaga gacttttaaa tgcgaagagt gtggcaagag ctacaacacc
      781 aagcttgggt ttaagcgaca cttggccttg cacgctgcca ccagtggcga cctcacctgc
      841 aaggtgtgtt tgcagacttt tgagagcaca ggtgtgctcc tagagcacct gaaatctcac
      901 gcaggcaagt cctctggggg cgtgaaagag aaaaagcacc agtgtgagca ctgcgagcgc
      961 aggttctaca cccggaagga tgttcggaga cacatggtgg tgcacacggg aagaaaggac
     1021 ttcctctgtc agtactgtgc acagagattt ggacgaaagg atcacctcac tcgacacatg
     1081 aagaagagtc acaatcaaga gcttctgaag gtcaaaactg aaccagtcga tttcctggac
     1141 ccattcacct gcaacatgtc tgtgcctata aaagatgagc tcctgccggt catgtccttg
     1201 ccttccagcg aactcttgtc aaagccattc accaacactt tgcagttaaa cctctataac
     1261 actccatttc agtccatgca gagctctggg tctactcacc aaatgataac aactttacct
     1321 ttgggaatga cgtgccccat agatatggac actgttcacc cctctcatca tcttgctttc
     1381 aaatgcccgt tcagttctac ctcatacgca atctctattc ccgagaaaga acagccctta
     1441 aagggggaaa tcgagagtta tctgatggag ttacaaggtg gcgcaccatc ttcatcccag
     1501 gattctcaag catcatcgtc taagttaggg ttagagcctc agagtggctc cccagacgat
     1561 ggtgctgggg acctctccct gtcaaagagc tctatctcta tcagtgaccc cctgaacaca
     1621 ccagcattgg atttctctca gttgttcaat ttcataccat taaatggtcc tccttacaat
     1681 ccgctctccg tgggaagcct tgggatgagc tattcccagg acgaggcgca ttcttctgtt
     1741 tctcagctgc ccacacaaac acaggatctt caggatcctg cgaacacagt gggccttggc
     1801 tctctgcact cactgtcagc agctttcacc agcagcctaa gctcaagcac taccctgccc
     1861 cgtttccacc aggcctttca gtagggtctg ggccgaggga ttcaccggag gtgcttgtgc
     1921 agccccgcct gcaaagacca tttatattct agtgcctact ttaacacaac acagaaactt
     1981 ctccttttgt ataatatcag gttttatgaa gccagtaaat aggaattagc ctctttgata
     2041 agctttgaaa tggttcgtgt ttaactacgt ttgctgtttc tcctgatttc ctgccagttg
     2101 tcatagtctc ggagttttat ttcatagagg agcgccatta ttatcactaa attttacaag
     2161 tcctgtgttc aaattactgt tagaccttaa cattctcact tttgtctaat agcaatgggc
     2221 attggacttt tttttttttg caaatgtgca gtacaatgta aatcttctat gaaatgtgtg
     2281 tgaagaactg aagtgtttca catttcttta ctagccacta aatggattca taatcaagtg
     2341 tgttttaaat gagttaagaa tccagtttgg ggagagtata gtggtttcct aaatacacca
     2401 tcatttgaga tcaatatatt ttgaagactg ctattgtctg gctaaaataa gaagtttcag
     2461 tatctattta atagaaacct agagatgtta cggggtgttc tgtgttagaa ctagccctca
     2521 ggctgatttg ccacatttca accatctttc cgttaacagt gtgtggcctc ggagtcttca
     2581 ggatcagtgt agaagtgttc tgttgtatgc ccttcacctt tcatacccca ggatggcttc
     2641 acaataccag cattcttact ttgcatgttg gtccagttag tgcagagtct tagaaccatt
     2701 gtgggacaat agacagtaaa tatatgaagc ccagagtggc tggctgcctg aatcgtcggg
     2761 gtgatagact cctcaccagg aagatggatg taaaacgtac agccaaaccc cagcacttgt
     2821 ctagagaatg tccactgttg ccagaactga gaactggact cctatcgcat cacttctaaa
     2881 acagcagtct tgcccgtgcg cccttgctca gtgcatatac atctttccct gccgtgtttg
     2941 gatggagaac ttaaaaatta aacacatcaa aaagcaactt gacgagttcc acagttttac
     3001 accaccaaaa gttgttaaga gcccactttt acacatctcc aggagacagg aggaatgtta
     3061 gaaataagtt gaatttatag aggaaacaga ggaaaataaa gcaaacacca aatgaatacg
     3121 aatgcaccaa ggatgtggtg ctcactgagc aaggtagcaa tgggcttcct cttgtcagac
     3181 agccaccaag aatgtcatcg gtagctccgc gtatatcttc ctaagggtta tttgtggcat
     3241 caacctacga gacttactaa gcacttgtta acaccttatt ctggacccct tctgttgggg
     3301 cagggagttt tatagaagag tatatatctc tttaaaaaaa aaaaaaagga agaaactatt
     3361 ttttaatctc tgagcactcg ttagccctgg ctggggaagc ttcttccctt gtgtaagggc
     3421 cagttatcac tgcatattgt attgtttacc catcactcta agcataaaca gattactgac
     3481 tatgatgcat tatttacaat gcctgggagt agtctaaatt gagaagtgta aactgtcctg
     3541 tgaatggggc tttcactata tgtcatacac acgcctagtg cacttcatag aatcagagct
     3601 gctccctaga gggctcaagc tcctggttct aaccctagag cagtagtttt tatacgtatg
     3661 tatttaaatt ttattgtgaa aaatacattt tattaaagaa agtgttccaa aggcattaaa
     3721 attatatacg ttaataagga aatacatttt aactcttcaa gctgctcctg agctgagggt
     3781 gggagcgcac tcactcagaa agtgggctct tcgcatgacc gcttccttag tttctatgaa
     3841 accgatcacg taccctaatg ttctagttgg atgattagtg ttcaatattg ctttaatcac
     3901 cacttttaaa aggagaggac atttggtgac agagcacaag taaataaaaa aacctattat
     3961 tatgtagagt tcacagacac cacatatgaa agcactagtt tattctatct aaaaattact
     4021 taagaagtca catttatgac ctgagacgtt ggccttcgta ggctgtatat atttcactgc
     4081 taattgaaaa aagggagtac caggatatat gaaataaagc atttcgcaat gggaatggcg
     4141 ccatatatgt gtgtgtgtgt atatatatat atatatgtat gtatatatat atatataata
     4201 aatatatttt tatcctaatt cttgcccagc gcagaactct aatacacatc ttccagggta
     4261 ccagtgttaa aacgtagagt cttactttcc tttgtatgta cacctctttg cctgttgctg
     4321 cccccacaga cttgaatgac atttcaaagt aagagggaaa taagcaaatt cttttcgctt
     4381 tattgactgc agtggtcact aaaccctttt ttgatagatt ttatattaaa aatcagtcag
     4441 cttttttatt ttcattgcac aatgttttaa caggaacgca acacagaatt ggcaacccct
     4501 accccatgga aaatactgtc actcgttctg tctgaagtag gactgcttag caataggcct
     4561 tgctagtgcc cttctcattc tccatggtcc tcgggatttc tgatagtgcc ttagcttaaa
     4621 agaaaagggg ttaacattaa ctaaacagtg tagtgtagag tttggacctc agacaagatg
     4681 ctgggccccg ttcattttga cttccacaca tgtgtgtgca gcttcaggag tgtgagcgcc
     4741 ttttcaggaa aggtctggca ctgtgagcaa tatagtccat tgatatttac caataaatac
     4801 cacctctgta gttaatgtct cttaagcttc cgtttaaaat cccgttactt gttgaggttt
     4861 ctaaaatgta agttgccttg gcagatcatg caccagtctg tgtgcagctt ttttcccttt
     4921 ttaatttcag ttggcgtttc tttcaagctg tgtgtgtttg cctatgtgtc gcttgcgctt
     4981 tatttttcta gtcatttgtg gaatatagtg atatattgtg ttaatttgga cagtgacggt
     5041 tttttgaaac catatactga ctgaaacatg agccagagct gattgcttta ttaagctaat
     5101 aatgaatgtt atagagtaca tatttcagga tcattcatct agtgagcagt acacatatag
     5161 gccaattaaa aaaaaataga gcttggtcaa cctctatact tcacatacta caagatatag
     5221 cactttcaaa atgaacctaa atttctacag aaactttcct atatgttatg ccttttattt
     5281 ttaagactta ttatattcat ttcaagtgcc attagacgat atatccgtag gcctttgata
     5341 tataatgctt tgtgtacaaa gaatagtaga tggtatttta aacaggtaca tttttacagt
     5401 gttttcctat cgatttgcta tattgcacag aatcagtgtg tgtcctttca taaggtttta
     5461 caatggttta tttttttaca aggtttacgt atctcaaagc acactgtctt cccagtccat
     5521 aagtaagtta aaagatacca gttcacccaa gttgcttcta gcctactgcg atccatgtga
     5581 cattgaagga gatctttgca gtgttgaata ttcgcccttc atgaaggcag gctggttttt
     5641 tttcctgaca aatgagttcg ttggtgaatt tgtctcgttt tactcatgat gtcagcagcc
     5701 gggtctacca cacaacatag cttgattgtg taagcctccg taaatacctt aaattgtatt
     5761 gtacccacag agcactcctc tgagattaag caagctaatg ccatcagcct tcatagcagg
     5821 cacggatcac caataagcct ttctacaatg ttagcagccc ctggagatgg aaggcagtgt
     5881 cttttgataa gttatctatc tctatagatg acacaggatt attactgatg tataagacac
     5941 ttcattgtat aagcttcagt ggtacagatg aaccagaatg aatgtctgtc ttctcagaag
     6001 ccctccttca acgttctatg ggatcatgct gctactgtca cttgggatac aactcttcat
     6061 ggtgctacaa acttctgtct cattcacttg tattttttta cccataggaa aaggactcta
     6121 taggtgtaaa ggtgtacaat atatttttat actgtgactt aaattgtcat taacaaactt
     6181 ttacaccacc acagtgtact catgtgcgct tgcaaaagga gatcttggat gtgcaaatgt
     6241 taccagaaca aacccagctt ttgtccacaa ggtgactgta actcagaatg gaaagtgagc
     6301 ttgacatagg gtgtggagtg aagaacatgc tataagttac taacagccct ttgaatttaa
     6361 caaaaactgg gaatccatta gagaaatgga ttgcatcatg cctgaacata agctgactgc
     6421 tgaaatattt ttttttagct aatgaaaaag tgtttggact agtgtactct aaaaaatgtt
     6481 ttaatggtaa agttttgagt caaatagaaa tgaaaaaaaa tctgcattcc agacttaatt
     6541 ttgtatattt ttattgcctt ttaaattgct attctgtgat attgggaaat caagtggctt
     6601 atcatgtata tcatgtactt aaaatgtatt cacaaactac tgttgtattt gtataaaata
     6661 tagacaaaga
//
LOCUS       NM_001436606            5891 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 4, mRNA.
ACCESSION   NM_001436606
VERSION     NM_001436606.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5891)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5891)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5891)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5891)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5891)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5891)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5891)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5891)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5891)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5891)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2248930.1,
                                           SRR26360181.2645223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-304             JAXUCZ010000005.1  60613698-60613813   c
            305-441             JAXUCZ010000005.1  60611539-60611675   c
            442-488             JAXUCZ010000005.1  60609743-60609789   c
            489-755             JAXUCZ010000005.1  60609265-60609531   c
            756-815             JAXUCZ010000005.1  60607510-60607569   c
            816-1042            JAXUCZ010000005.1  60605329-60605555   c
            1043-1146           JAXUCZ010000005.1  60599244-60599347   c
            1147-5891           JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5891
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            189..304
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     misc_feature    270..272
                     /gene="Aptx"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MLLGQEARYPPRAK"
     exon            305..441
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1301
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform a is encoded by transcript variant 4;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform a"
                     /protein_id="NP_001423535.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MRVCWLVRQDCWHQRIKLPHLEAVVIGRSPETKITDKKCSRQQV
                     QLKAECNKRYVNVKQMGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEV
                     AESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKI
                     SMKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVG
                     EKVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLE
                     SQAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    312..596
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interactions with ADPRT/PARP1 and NCL.
                     /evidence=ECO:0000250"
     misc_feature    315..614
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    315..614
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    order(390..395,429..434,438..440,498..503)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    order(390..395,429..434,438..440,498..503)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    627..758
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    642..656
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    669..671
                     /gene="Aptx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQC5; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); phosphorylation site"
     misc_feature    762..1067
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    762..1067
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    792..794
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    849..863
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    1023..1025
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1035..1040
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    order(1044..1046,1050..1052,1056..1064)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(1044..1046,1050..1052,1056..1064)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    1044..1058
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Histidine triad motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00464"
     misc_feature    1050..1052
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    1050..1052
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    1056..1058
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1101..1103
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1119..1292
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    1119..1292
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            442..488
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            489..755
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            756..815
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1042
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1146
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..5891
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagat ggtaacaata ttctcatctt taagaatatg atttctttga tcttcatttc
      241 tgaatacagc aatcgtgcag aaggcctgca tgctgcttgg gcaggaggca agatatcccc
      301 caagagccaa gatgcgggtg tgctggttgg tgagacagga ctgctggcac cagcgaatca
      361 aacttcccca tttagaagct gttgtgattg gtcgaagccc ggagaccaag atcacagata
      421 agaaatgttc ccgacagcaa gtacagttga aagcggagtg taacaagaga tatgtcaacg
      481 ttaagcagat gggggtcaat cccaccagca ttgacgaagt cgtcattggg aaggaccggg
      541 agatgaagct gctgcctggt caggttctcc acatggtgaa tgaactttat ccatacatgg
      601 tggagtttga ggaggtggca gagagcccta acgtaacaca gaggaagaga aagaggccag
      661 actgtgatag tcaggagatg gaagctgagg ctggggccag ccccagccag tgctctgtgt
      721 cccctaagac gggcaagcat ggagccgcca aggaggaatc actgggccac tggagtcaag
      781 gcttgaagat atctatgaaa gaccccaaaa tgcaggttta taaggatgat caggtggtgg
      841 tgattaagga taaatacccc aaggcccggc accactggct ggtcttacca tgggcctcca
      901 tttccagtct gaaggttgtg accagtgaac acctcgaact tctcaaacac atgcacgcag
      961 taggggaaaa ggtgatagca gattttactg gatccagcaa actgcgcttc cgactgggtt
     1021 accatgccat tcccagcatg agccatgtac atcttcatgt gatcagccag gattttgatt
     1081 ctccttgcct taaaaacaaa aagcattgga attctttcaa tacagaatat tttctggagt
     1141 cacaagctgt gatcaagatg gttcaggaag ctggcagagt gactgttaaa gatgggactt
     1201 gcgaactctt gaagctgcct ctccgttgcc atgagtgtca gcagctgctg ccttccatcc
     1261 cacagctgaa ggagcacctc aggaagcact ggggcgggtg acactcgcct tggtgaccga
     1321 gtgcagtgct agcatcattc tgcattgcct gcgctccgtt cagtcctgaa ctaaagcatg
     1381 cagctcttca aaacaaagct tattattctt gagtgaccac acagggtgac tctgggtcag
     1441 gaactgggaa tatgggtttg tatggtatat tttctggtaa tggaggatga gacatgcctg
     1501 atcactcttc ccaagaccat gtcaggcctg actaataaga gggcagagcc agcttgaggt
     1561 tcaaatacaa gatgtagaag cagaggactg gtaatgtatt tgttcctacc cttgcccctg
     1621 gatcatgttc tatcttttta tcaagatagc tgaggttctg agggggcctg gttcctgctc
     1681 tatgatattc ctcttccctc catgaggagg ctttcaatct actgtaccag gctgagtgcc
     1741 tgggtgaaca tatgtggcag tcatctgcac agagagatac tttgtgtatg actgtgccag
     1801 ggaactggaa gtggtaatat tgggcacagt atgttaacag tacagcctgt gtcgagggca
     1861 aactggggta atgtgaactg ccagtaaaca gtacatcctc tgctgagggc agcctggggc
     1921 agtgtgaact gccagtaaac agtacagcct gtgctgaggg cagcatggaa cagtgtgaac
     1981 tgttagtgaa cagtagtctg ttctgagggc agccttgtac agtgatgtca gttaacagtg
     2041 cagtctgttg agggcatcct gggatggtgt gaactgtcag ttaacagtgc agtctgttga
     2101 gggcatcctg ggatggtgtg aactgtcagt taacagtgca gtctgttgag ggcatcctgg
     2161 gatggtgtga actgtcagtt aacagtgcag tctgttgagg gcatcctggg atggtgtgaa
     2221 ctgtcagtta acagtgcagt ctgttgaggg catcctggga tggtgtgaac tgtcagttaa
     2281 cagtgcagtc tgtgttgagg gcagcctggg cagtgtgtat tgttagcttc aggcagattt
     2341 tacggaggct tcagccactg ctcttgagaa ttacagaaca tttaactaaa cttcggataa
     2401 tgtatcttag aaaaacagat gttgcaaaat agttcattta ctttccacct gatacaatat
     2461 agtttagcac atcagtatta aaatgagtat ttgctgtaaa ctactaggag tgtctgtatc
     2521 agacagcgta agaatgtcag gtataatgag aaacatttgg ggaatgaggt gaccatgctt
     2581 acattcttcc ttctgcccaa aatagatttt tttaagactg gggtgagtgc atgctgccct
     2641 tcctaggacc tgagttttgt tcccggcatc catattaggt ggctcacagc tgcctgtagc
     2701 tccagggatc ctgcacctgc ttcttgacct ctgtgggcac tgcattcaag tacacaaacc
     2761 tgaatacaga cacacattca cacataatta aatctgtaaa aatcagatct cgggctggag
     2821 agatggctca gtggttaaga gctcctccag aggtcctgag ttcaattccc agcaaccaca
     2881 tggtggctca caaccatctg taatgggatc tgatgccctc ttctggtatg catggagaca
     2941 gccacagtgc acttatacat aaataaatac ataaataaaa aaaatagatc tcttagagga
     3001 aaaatgtcaa taatgactgg caggaagcag gtattgaggt attgaggttt attcattccc
     3061 tagccctcct ctccgaaatg ggcttttatc accatgggga agaagactgt ctggactctg
     3121 gattacttga cagacatgtc attgtacaat tagttgaagc tttccttcag agtcagaggg
     3181 agggatgttg ggagactgca aagtagaaga aagccagcca catttaaagc taggcacagt
     3241 ggcaaattct cttgcaatcc caaatttagg aggtggtaga tccaggaggg ccaggcattc
     3301 caggttatcc ttgtctatat ggtgaacttg aggtctggac tacatgagac cctatgtcac
     3361 agaagcaaat aaataaaaga tttaaaaagg ggaaataaaa ttctatctaa ggtaccaaag
     3421 catattattt ggcccatcat ggccaggcaa gaccagttgt tatcaaagca gctgttatgg
     3481 ctggaatctg ggataactca ggctcatgtt ctggagcgtg ggtcctttcc ttgcagtgtt
     3541 gtttagatga ctgtgaagcc attagggtga agccgggctg gcagaagtag gtgtctagga
     3601 gcaggcaggc cctgaaggct ataccctttc ccggctcctg gtgggctgct ttacctcctg
     3661 tgaacaggac acccatctct gctactatgg actgacactg tgtgtgtgtg cgcgtgcgca
     3721 cacgcgcgcg cgtgtgtaca caagaggaca atttctggaa gtcaattgtc tccaccatat
     3781 tggccctagg gattgactca ctagcttgac tcagtgtctt tacccactga gttccagtaa
     3841 gtcagaagta ctcttttaag aaatagcaac ttagggcctg gagtgacggc tcaggggtta
     3901 agagcactga ctgctcttcc agaggtcctg agttcaattc ccagcaacca catggtggct
     3961 cacaaccatc tgtaacagga tccgatttac atataataaa taaataaatc ttaaaaaaaa
     4021 gaaataactt aattctcaag tacgtacaca cacacacaca cacacacaca cacacacaca
     4081 cacacacaca ctctctctct ctctctccta ccttatccca agctacccta aactcaccat
     4141 gtagactagg atgaccttga acttgctgag atctgccagt ccagagccag ggtactggga
     4201 ttcaagtatc ccaccaaaga ggaaaataag caaatgtaca aggattagat agacattgcc
     4261 cataattaat taaaattcag tgttttctga gagtggaaat attgtcatga aatattccct
     4321 tttgcagcaa tgctcagatc tgcctcttta gaatggtctt tctttttgaa tgttgctaat
     4381 ggtgtactgg ctggttttgt gtatcaattt ggcacacgct agagtcatca gagaggaagg
     4441 accttcagtt gagaaaatgc ctccatgagc tccagctgta agacattttc ataattaggg
     4501 atcagtgggg ctagcgccat tgtgggtggt accactcctg gactggtggt cctgggtcct
     4561 ataagaaggc aggctgagca agccagggga agcaagccag tgtggggtgg gggcacccca
     4621 ctcatggtct ctgcctcagc tcctgtctcc aggttcctgc tctgtctgag ttcctgtcct
     4681 ggctgccttt ggtggtgaac atgactgctg tgtgattgcc tgtctgtcac tcgggcttta
     4741 tggtatccca gggcattcag aattgggagg tgcataatgg agtgttattt aagccataaa
     4801 taatgaacag aatggaattg tgtcctttgc cagaagacag ataccctgga ggtcatcctg
     4861 tgaaacgcaa tcagccagac tcagaacagt cacctcatac tggtatttca aaggtcttgg
     4921 ctctcctgac tctatgccca tcgtgaggca gagcatagca gaggttgaag catgtacaaa
     4981 gccttcttgg cacatgggac aaagaggcag agacaccact ttgttctgag attggtctta
     5041 ctgtgtagca aagactgacc tggaattcat gcagctcagt ttggtcttga gttcaagacc
     5101 caactgcctt agcagttctg ggtgtgtgct aggaagtgtt ctcagataat gttttcagag
     5161 cacgagacac cttcatgtgt aggctatcat gagtcaacta acctttctgt ggctggaccc
     5221 tgcaggtaag gggtggagcg cagggcagag gagagacttc tggcactcta aggagcctgt
     5281 ggaccaccta gattcttacc tgctgctaac atttccacac cacaggcacc ctctagccta
     5341 tggcagctgg gaacttattt ttgctttcaa gaacccagtg ataggtctgt ttctcaaata
     5401 cagctgatgt ggctgacctt gagtgaaagg agactgaagg ttttaggaga ccccagtatg
     5461 tagacctgac tgaacttgcc cctgaagctg acagcccatt gcatactctt cacatgaatg
     5521 agaaaaaggt gcctgttgta tgtggaggcc tttaacccag atcccctgag gccggagccc
     5581 atgtgaggca caactacatg accacatagg gtgatgtgat ggtttgcata tttggcccag
     5641 ggagtggcac tattagaagg tgtggccttg ttggaggaag tgtgtcactg tgggggggtg
     5701 ggcttggaga ccctcctcct agctgcctgg ggatgctcag tctgttcctg gcttcctttg
     5761 gttgaagatg tagaactcag ctcctcctgc accaggcctg cctggatgct gccatgctcc
     5821 tgccttgata atggactaaa cctctgatct gtaagccagc cctaattaaa tgttgtcctt
     5881 tataaaactt a
//
LOCUS       NM_001436652            2991 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus zinc finger protein 362 (Zfp362), transcript
            variant 3, mRNA.
ACCESSION   NM_001436652 XM_039109415
VERSION     NM_001436652.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039109415.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.30256.1,
                                           SRR26643295.22787.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000005.1  146437569-146437882 c
            315-378             JAXUCZ010000005.1  146421491-146421554 c
            379-625             JAXUCZ010000005.1  146421103-146421349 c
            626-953             JAXUCZ010000005.1  146417641-146417968 c
            954-1178            JAXUCZ010000005.1  146416686-146416910 c
            1179-1257           JAXUCZ010000005.1  146407848-146407926 c
            1258-1416           JAXUCZ010000005.1  146407561-146407719 c
            1417-2991           JAXUCZ010000005.1  146403469-146405043 c
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2991
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="zinc finger protein 362"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
     exon            1..314
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            315..378
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1533
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="isoform b is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 362 isoform b"
                     /protein_id="NP_001423581.1"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
                     /translation="MAEPRFNNPYFWPPPPTMPSQLDNLVLINKIKEQLMAEKIRPPH
                     LPPTSASSQQPLLVPPAPAESSQAVMSLPKLQQVPGLHPQSVPQPDVALHARPATSTV
                     TGLGLSSRTPAVSTSESTPGTGTGTSTPSTPTTTSQSRLIASSPTLISGITSPPLLDS
                     IKTIQGHGLLGPPKSERGRKKIKAENPGGPPVLVVPYPILASGETAKEGKTYRCKVCP
                     LTFFTKSEMQIHSKSHTEAKPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSYCDKS
                     FRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRA
                     YSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHTVVEHLVSHHSPQR
                     TESPGIPVRISLI"
     misc_feature    <355..>669
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <355..>669
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    955..1017
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    955..1017
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    991..1068
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    991..1068
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1033..1101
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1033..1101
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1039..1101
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1039..1101
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1054..1056,1060..1062,1066..1068,1072..1077,
                     1084..1089,1096..1098,1138..1140,1144..1146,1156..1161,
                     1168..1173,1180..1182,1228..1230,1234..1236,1240..1242,
                     1246..1251,1258..1263,1270..1272)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1054..1056,1060..1062,1066..1068,1072..1077,
                     1084..1089,1096..1098,1138..1140,1144..1146,1156..1161,
                     1168..1173,1180..1182,1228..1230,1234..1236,1240..1242,
                     1246..1251,1258..1263,1270..1272)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1075..1152
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1075..1152
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1123..1185
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1123..1185
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    <1189..1347
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <1189..1347
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    1207..1275
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1207..1275
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1297..1359
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1297..1359
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1393..1449
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1393..1449
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            379..625
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            626..953
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1178
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1257
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1416
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..2991
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactcgcc ggagccccgg ggccgggcgg gctgcgcagc cgagaggcgg ggggccggac
       61 gcggctcgct cgccgggccc agcgcaccgg ggccgcgcgg ctgcacagcc ggcctccgcc
      121 gccgcggcgc ctgcagaacc cagaagtgaa cagcaggcga cccggaaggt ttgcgcgccg
      181 ctccgcaccg agccccagcc gcgcgccgcc gctaccgccg ccgccgccga agccgggagc
      241 ccccagcccg gccctactcg ggccgccggg ctcggggctg cggccgcgtc ccggagcgcc
      301 gccagcactg ccaggatggc cgaacctcga tttaacaacc catacttctg gccccctcct
      361 cccaccatgc ccagccagct ggacaacctg gtcctgatta acaagatcaa agagcagctg
      421 atggccgaga aaatccggcc gcctcacctg ccacccacct cagcctcgtc acagcagcca
      481 ctgctagtgc cccccgcgcc cgccgagagc agtcaggcgg tcatgtcgct gcccaagctg
      541 cagcaggtgc ccgggctgca cccgcagtcc gtgccgcagc ccgacgtggc gctgcacgcg
      601 aggccggcca ccagcactgt cacaggtctg gggctttcct ctcggacccc cgctgtgagt
      661 acatctgagt caaccccagg cacgggcaca ggcaccagta ccccatccac acccaccacc
      721 accagccaga gccgcctcat cgcctcatcc cccaccctca tctcagggat caccagcccc
      781 cccctcctgg actccatcaa gacaatccag ggccacggcc tgcttggccc ccccaagtct
      841 gaacgcggcc gcaaaaagat caaggcagag aacccagggg gtccccctgt ccttgttgtc
      901 ccctacccca tcctggcctc cggtgagacc gccaaggagg gcaagacata caggtgtaag
      961 gtatgcccgc tcaccttttt caccaagtct gagatgcaga tccactccaa gtcgcacacc
     1021 gaggccaagc cccacaagtg cccacactgc tccaagtcct ttgccaatgc ctcctacctg
     1081 gcccagcatc tgcgcatcca cctgggtgtc aagccctacc actgctccta ctgtgacaag
     1141 tccttccggc agctctccca cctccagcag cacaccagaa tccacacagg cgacagaccc
     1201 tacaagtgcc cacatcctgg ctgcgaaaag gctttcactc aactctccaa cctccagtct
     1261 caccagcgtc agcacaataa ggacaagccc tacaaatgtc ccaactgcta ccgggcctac
     1321 tcagactccg cctccctcca gatccacctc tccgcccatg ccatcaagca cgccaaggcc
     1381 tactgctgca gcatgtgcgg gcgggcctac acctcggaga cctacctgat gaagcacatg
     1441 tccaaacaca cagtggtgga acacctggtg agccatcact caccccagag gaccgagtcc
     1501 cccggcatcc cggtgcgaat ctctctgatc tgagcccacc tgtggtgccg ccccgcccac
     1561 ttggcagcac ccagcctaac tcccgctggg gcctccagga accaccaagc tctctcacga
     1621 cctacccaac ctgccagaaa gcttggtcca tagaagccct gcctgatccg gctcctgggc
     1681 agccaggcca actgcaagat tctgggctgt tctggtggca tccaaagacg atctcagagc
     1741 actttgaacc tgtctgtcgg gttttctttc tttttttttt ttttttttgt tccccctccc
     1801 tcacttgctt cactgtctct tgtttttttt ttttttaaag tttgttttgg aaataacaaa
     1861 aaggatattt attggccaga atgttggtgc tgctaagaac gagagattca aaggactgga
     1921 cggacggata cagagagaac cagagggcag cgtgggaact tctctgacca caacctcagg
     1981 tcttgagggg aggcctgggg ttctggactt caaaggggac tccctccctc aggtgggaag
     2041 agacaggagg cagctggagt gagcccttcg tccctgtcac ccagtcaaac tgcctgagct
     2101 ttgccctagc ccttgtgagc agcgggtaca gcagctgcca cctgcctggc tttaggggat
     2161 ggaaaatgag agaggtctgg agagccgcgg gaccaaaggg tgcagtgacg gctgggtggc
     2221 gagcccaggg aatgggctgg gggtgtgcca ggtgagacct ggcccctccc ctgctgccct
     2281 gaagaccacc ccagtctacc tcggtgctgg ccaggaaacc tatcggctac ctctcccacc
     2341 actccagact gtgggcaagg ggatggagag ggagggggcc tgggactaag tgcccttccc
     2401 agaatttcct ccagaagggt acagtgccca gggaggggtt gtccttctct ccacggatga
     2461 gacggggact cccccaaccc agaccccagg ccctgcggca gggataggag cctctgaagg
     2521 aggccccagg agcagaccct gcccccagcc ccccaagaca tatcccaatc cgaaagccat
     2581 gcgtgtccgt gtatatagga actatgtaca gaacccagag aagccccctt ccacatcacc
     2641 cccagagaag aaaactagac aaaactcatc tatatattct gtatctggag tccgtttgaa
     2701 tattaactgt gttattttta tacacttttt aagccttaac tcgccattga tttaccagtt
     2761 taacgtttcc tggggtttct tttccactgg gaggggtctc agccccccac ccaccccaac
     2821 cccttcgttt gacttgcgtc gtctgatact cagtattgta gctttcgtcc gcatgttact
     2881 accctgtaaa tatgctgttc caataccgtt ggcatccttt gcttttttct atgggacctc
     2941 caggccacca tatttagaaa tagttacctt attaaaaaag agaaaacagt c
//
LOCUS       NM_001436646            4011 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus chondroitin sulfate
            N-acetylgalactosaminyltransferase 1 (Csgalnact1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436646 XM_008771114
VERSION     NM_001436646.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4011)
  AUTHORS   Sato,T., Kudo,T., Ikehara,Y., Ogawa,H., Hirano,T., Kiyohara,K.,
            Hagiwara,K., Togayachi,A., Ema,M., Takahashi,S., Kimata,K.,
            Watanabe,H. and Narimatsu,H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is
            necessary for normal endochondral ossification and aggrecan
            metabolism
  JOURNAL   J Biol Chem 286 (7), 5803-5812 (2011)
   PUBMED   21148564
REFERENCE   2  (bases 1 to 4011)
  AUTHORS   Watanabe,Y., Takeuchi,K., Higa Onaga,S., Sato,M., Tsujita,M.,
            Abe,M., Natsume,R., Li,M., Furuichi,T., Saeki,M., Izumikawa,T.,
            Hasegawa,A., Yokoyama,M., Ikegawa,S., Sakimura,K., Amizuka,N.,
            Kitagawa,H. and Igarashi,M.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required
            for normal cartilage development
  JOURNAL   Biochem J 432 (1), 47-55 (2010)
   PUBMED   20812917
REFERENCE   3  (bases 1 to 4011)
  AUTHORS   Gotoh,M., Sato,T., Akashima,T., Iwasaki,H., Kameyama,A.,
            Mochizuki,H., Yada,T., Inaba,N., Zhang,Y., Kikuchi,N., Kwon,Y.D.,
            Togayachi,A., Kudo,T., Nishihara,S., Watanabe,H., Kimata,K. and
            Narimatsu,H.
  TITLE     Enzymatic synthesis of chondroitin with a novel chondroitin sulfate
            N-acetylgalactosaminyltransferase that transfers
            N-acetylgalactosamine to glucuronic acid in initiation and
            elongation of chondroitin sulfate synthesis
  JOURNAL   J Biol Chem 277 (41), 38189-38196 (2002)
   PUBMED   12163485
REFERENCE   4  (bases 1 to 4011)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_008771114.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50404.1,
                                           SRR26643289.38253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000016.1  25762253-25762375
            124-258             JAXUCZ010000016.1  25843836-25843970
            259-407             JAXUCZ010000016.1  25915023-25915171
            408-1335            JAXUCZ010000016.1  26002429-26003356
            1336-1552           JAXUCZ010000016.1  26052126-26052342
            1553-1654           JAXUCZ010000016.1  26065782-26065883
            1655-1833           JAXUCZ010000016.1  26079602-26079780
            1834-1928           JAXUCZ010000016.1  26080645-26080739
            1929-2010           JAXUCZ010000016.1  26091895-26091976
            2011-4011           JAXUCZ010000016.1  26095306-26097306
FEATURES             Location/Qualifiers
     source          1..4011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4011
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
     exon            1..123
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            124..258
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            259..407
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            408..1335
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    699..701
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="upstream in-frame stop codon"
     CDS             708..2300
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /EC_number="2.4.1.174"
                     /note="chondroitin beta1,4
                     N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001423575.1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
                     /translation="MVRRGLVGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLP
                     RANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGQDQASDAT
                     SLRSGWDPEPKAQADILAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETG
                     LTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRPYTAADFIEGIYRTERDK
                     GTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKKEKLNMANTLINVIVPLARRVDKFRH
                     FMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSR
                     GKGLDVGARFWKGSNVVLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGI
                     IYGHHDAVPALEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVH
                     LYRKYLHSNLIVIRTPVRGLFHLWHEKHCMDELTPEQYRMCMQSKAMNEASHGQLGML
                     VFRHEIEAHLRKQKLKASSKKT"
     misc_feature    909..2222
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     misc_feature    909..2222
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     exon            1336..1552
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1654
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1833
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1928
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2010
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..4011
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgttgga actggaggtg gagccgagcc cagggccgcc tcgcaggagg gaaagttcgg
       61 cggcgccggg cgggagcagc gtagccaagg gagccggctc cgctgtctgc agggttgctt
      121 ggggtccctt gatcatgaat gacagattga agagttgcca tgtggatcta cagtcctcaa
      181 tgtgagaagc tttaaacaat cttttctatg gctggaatcc tcaaatgttc tacttaattg
      241 cctctggagc atcaccagtg gtggcgctga gctgaacacg gtgctagcag aagggggcgg
      301 tactttccct ctggaccctg acttggaagc caagtgcgac tcgagcgcag tcaccgccag
      361 aagcagatgt gtgagcggag cagctgtgcg cctctctttc tgccgaggat ccccctcatc
      421 ttcagcacat caggaagact atgatggaaa caaaagaaag aacttggagg ttccacttaa
      481 ctgattgttt ctgcctagag gatcttctct tggaagcagg agagccttct catgtaatgg
      541 ctgacttcca aagacaggct atgttctaga aggaaatgga tggaatcagt tcaggggact
      601 tcagccgcac tgtggtctaa ccagaaaagc ccgtgttggg ggccctcctg gtgccctggg
      661 atgttgcata ctctggacct ggatgcatgg cccgcacctg agtgaggatg gtccgacgcg
      721 ggctggtggg gtggatttcc cgggtagtga ttctgctggt gctgctctgt tgtgccatct
      781 ctgttctcta catgttagcc tgcaccccaa aaggcgacca agagcagctg ggactgccac
      841 gggccaacgg ccccacaggc aaagatggct accaagcggt gctacaggag cgtgaggaac
      901 agcatcgcaa ctatgtgaat agtcttaagc gacagatcgc gcagctcaag gatgaactgc
      961 aggcacgcag tgagcagctc cgcagtgggc aggaccaggc cagcgatgcc accagcctgc
     1021 ggtcaggctg ggaccctgaa cccaaagccc aggctgatat actggccttc ctgcgtgggc
     1081 aggtggacaa ggctgaggtc cacgccggtg tcaagctggc caccgaatat gctgctgtgc
     1141 cttttgatag cttcactctg cagaaagtat accagctgga gactggtctg acccgccacc
     1201 ctgaggagaa accagtgagg aaggacaagc gagatgagct agtggaagct atcgaatcag
     1261 ccctggagag tctaaacagc cctgtggaaa gcagcccaca ccagcgccct tacacggctg
     1321 cagacttcat agaagggatc taccgaacag aaagggataa aggcactttg tatgagctga
     1381 ccttcaaagg ggaccataag catgaattcc aacgacttgt cctatttcga ccttttggcc
     1441 ccatcatgaa agtgaagaag gaaaagctca acatggccaa cacacttatc aacgttatcg
     1501 tgcccctagc gaggagggtg gacaagttcc ggcacttcat gcagaacttc agggagatgt
     1561 gcatccaaca agatgggaga gttcatctta ccgttgttta ttttgggaaa gaagaaatga
     1621 atgaagtcaa aggaatactt gaaaacactt ccaaggctgc caattttaga aacttcacct
     1681 tcatccagct gaatggagag ttctcccggg gaaagggact ggatgttgga gcccgcttct
     1741 ggaagggaag taatgtcgtg ctctttttct gtgatgtgga catctacttc acctctgagt
     1801 tcctcaacac atgtaggctg aacacacagc cagggaagaa ggtattttat ccggttcttt
     1861 tcagtcagta taaccctggc ataatctacg gccatcatga tgctgtccct gccctagaac
     1921 agcagctggt cataaagaag gaaacaggat tttggaggga ctttggattc ggaatgactt
     1981 gtcagtaccg gtcagacttc atcaacatag gtggatttga cctggacatc aaaggctggg
     2041 gcggtgaaga tgtgcacctg taccggaaat atctccatag caacctcata gtgatacgca
     2101 cgcctgtacg gggacttttc cacctttggc atgagaagca ctgtatggat gaactgaccc
     2161 ctgagcagta caggatgtgc atgcaatcaa aggctatgaa tgaagcatcc cacgggcagc
     2221 tgggaatgct tgtcttccgg catgaaatag aggctcacct tcgcaaacag aagctcaaag
     2281 ccagcagtaa aaagacatga cctcccaggt aaagattagc caagacgttt aaattttgtg
     2341 cctttggcag ttactgaaga agtagatgca acaaggtata gacttccaca aagggcaaca
     2401 gagaatctga ctgatgagtg acagatgaat gaagagtctc gggtttctgt tggctctgtg
     2461 tatgctggtg actctgactg tgtttacagc caaatgagct ctctggtccc tgctccctga
     2521 aatagtcaca accggtttca gaaaaccaga aggagctgca agcccactga cttctcttct
     2581 ttggattggt tacatcagag ggctttggta ctactaggac taccaaaggc tcagatggag
     2641 ctctcggacg gagcagagga cctgtgtgaa aagtggagct ctgacattag tgtcctccac
     2701 cagaccgtga gcaaaatcaa agggacctgg aaacaaacca tccaaactgt catttcccta
     2761 gtattaactg aaaaacaaac aaacaaacaa acaaaaaccc taaaaaacaa aaaaaagaca
     2821 aaaacaaaaa caaaaaacaa agccaacaac aactacaaca aaaacccctc tctttcccat
     2881 tattgtttag tcatctctgt tctaaaaatg cacttttttt gcttctgagc attatgctta
     2941 tttaattacc catttccaag ccttagtagg agtacattgt agtacacaca tttttatgat
     3001 ttttttaaag atttgttttt atgtttttgc tgatttgttt acttgagaca gtcttgacac
     3061 agagcccgag ataacttgaa atcctgatcc tcctgtctcc gaagcctgag tgctgagatt
     3121 acaggtagct agaagatacg tgcagaggcg tggagtgagg agctccagtt gcaggcatgt
     3181 ggagctgatc caaggacttg ccagtctccg accacaagaa ggctacatgt ggggctgcag
     3241 agagaaaggt atctacaaac taagactgtc ggaagaggag caatcaaaca ctggaaaaag
     3301 aaaaagatac ttttcacaaa gaaaggacac taagaagacc ttcgtgtatt tactagagaa
     3361 tataatttct cttctggaga aatgggacca ctttcttacc tgtttgaata aaccaaagtt
     3421 atgaaccaaa tgatcacttt tcaaaacagg gtgctcttct tggtctctgg tttgcataaa
     3481 gaagaaactg caggaaatat atatatgtat atatatatat atatatatat atatatatat
     3541 atatatatat attttgaaag acaaatccat taacccagtg aggtggaaga ttctgctcca
     3601 tttccattca ctcctggcta ggtggaagca acttattttt aaaataagca atgttacctg
     3661 attgccaaga cgcttctgaa gcattttctt acaactccaa atttgttttt ttaaaaaaaa
     3721 taaatctgat taacattgag tggtttctac atccatgtgc aaattattta tttattagcc
     3781 agcaccagat gcatgagcta attacctctc ctgtctctgt gccttctgtt tgcccacagt
     3841 gaactcattg tttaaatgct tcaagaacac tcaagctgtg tgtttaaaaa aaaaaaaagg
     3901 attgtattga tttgtactgg tagtttataa aatttaatta aaacacaaga catgaatgaa
     3961 aggtggcatt gcacagctaa taaaatttgt gaatttgatt tctttccata a
//
LOCUS       NM_001436658            5659 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 63 (Gpr63), transcript
            variant 2, mRNA.
ACCESSION   NM_001436658 XM_039109424
VERSION     NM_001436658.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5659)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_039109424.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3033962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000005.1  43469111-43469334
            225-5659            JAXUCZ010000005.1  43518406-43523840
FEATURES             Location/Qualifiers
     source          1..5659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5659
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
     exon            1..224
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     exon            225..5659
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    349..351
                     /gene="Gpr63"
                     /note="upstream in-frame stop codon"
     CDS             373..1650
                     /gene="Gpr63"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 63"
                     /protein_id="NP_001423587.1"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
                     /translation="MVVSGVLTAPAVLTTPHTGTSNMTFVVYENSPMNITAPLPFQHP
                     SPGPLLRYSLETMTSTGFSSLAVNSTVVTPAPAVFKSLNLALQIILSAIMIFILFVSF
                     LGNLVVCLMVYQKAAMRSAINILLASMAFADMLLAVLNMPFALVTILTTRWIFGKFFC
                     RLSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATAFSVAFP
                     LAVGNPDLQIPSRAPQCVFGYTTNSGYQAYVILISLISFFIPFLVILYSFMGILNTLR
                     HNALRIHSYPEGICLSQVSKLGLMSLQRPFQMSIDMSFKTRAFTTILILFAVFIVCWA
                     PFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMM
                     PKSFKFLPRLPGHTRRRIRPSAVYVCGEHRTVL"
     misc_feature    634..1536
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    634..1536
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    637..717
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    637..717
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    736..813
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    736..813
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    order(802..804,811..816,850..867,871..876,883..885,
                     1009..1011,1015..1029,1105..1107,1114..1122,1126..1134,
                     1138..1143,1369..1371,1378..1383,1387..1392,1399..1401,
                     1435..1440,1444..1452,1459..1461,1468..1473)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    order(802..804,811..816,850..867,871..876,883..885,
                     1009..1011,1015..1029,1105..1107,1114..1122,1126..1134,
                     1138..1143,1369..1371,1378..1383,1387..1392,1399..1401,
                     1435..1440,1444..1452,1459..1461,1468..1473)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    850..942
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    850..942
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    967..1035
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    967..1035
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    1105..1194
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1105..1194
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1309..1401
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1309..1401
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1438..1515
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
     misc_feature    1438..1515
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
ORIGIN      
        1 gggagccgcc ggcagccggc aaggcggagg cactgccggg cgatgccccg actctccgcc
       61 gccgcctcct cggcctcctc ctgcgctggg ggctcggagc tgcggagctg cggtgcgatg
      121 tccgcaaagt tccgggaggc agcggtcacc aactcccggc tctatcgccg cggcgccttt
      181 tgtgcgaggt gtgagcgcgt ccggggcagg cgagcgcatc ctgggcaaac agattcttgt
      241 ggaagatgga gctgtgtcca ttttccagaa tgtgcatccg agcccatcag tggaacctga
      301 cctgacagca ctgtatggaa atgcccgaag aggacccaca tttctgcctg aacctgccac
      361 cctcctaaaa acatggttgt ctccggagtg ttgactgctc cggcagtgtt gactacaccc
      421 catactggga catccaacat gacatttgta gtctatgaaa actcccccat gaatattacg
      481 gcccctctac catttcagca tcctagccct ggtccactgc ttagatacag tcttgaaacc
      541 atgactagca ctggatttag ttccttggca gtgaacagca cagtggtgac tccagcacca
      601 gcagttttta agagcctaaa cttagctctc cagatcattc tctcggctat catgatattt
      661 attctgtttg tgtcttttct tggaaatttg gttgtttgcc tcatggttta ccaaaaggcc
      721 gccatgcgct ctgcaattaa catccttctc gccagcatgg cttttgcaga catgctgctt
      781 gctgtattga acatgccctt tgccctggtc actattctta ctaccagatg gatatttggg
      841 aagttcttct gccggttgtc tgctatgttt ttctggttgt ttgtgataga gggtgtggcc
      901 atcctgctca ttattagtat tgataggttc ctgattattg ttcagaggca agataagcta
      961 aatccataca gggctaaggt tctcattgca gtctcctggg caactgcttt ttctgtagct
     1021 tttcctctgg ctgtgggaaa ccctgatctg cagatacctt ccagagcccc acagtgtgta
     1081 tttgggtata caaccaactc cggctatcag gcttatgtga ttttgatttc actaatttcc
     1141 ttctttatac ctttcctggt gatactctat tcatttatgg gcatcctcaa cacccttcgg
     1201 cacaatgcct tgaggattca tagctacccg gaagggatat gcctcagcca ggtcagcaaa
     1261 cttggtctca tgagtctaca gagacccttc caaatgagca tcgacatgag ttttaaaaca
     1321 cgtgccttca ccaccatttt gatcctcttt gccgtcttca ttgtctgctg ggccccattc
     1381 accacctaca gccttgtggc taccttcagt aagcactttt actatcagca caacttcttt
     1441 gagattagca cctggctact ctggctctgc tacctcaagt ctgcattgaa cccactgata
     1501 tactactgga ggattaagaa gtttcacgat gcctgcttgg acatgatgcc caagtccttc
     1561 aagttcttgc cacggctccc tggtcacaca aggcgacgga ttcgccctag tgcggtctat
     1621 gtgtgtgggg agcatcggac ggtgttgtga atacctgaac tcttgagacc tatctaatga
     1681 tgatggtttt tgattgactg ggattttttt catatggctt ctaaagtttt attggtttta
     1741 atagtatgtg tgcgtgtgtg ggggcatgta aacggaatgg taaatacttt gctcctcaaa
     1801 ccaaggtaat actgtaagaa agtggtcaca tatgtttacc tctaggttaa gaaaatttta
     1861 gcgcacgcgt gcgcgcgcgc gtgtgtgtgt gtatgtgtgt gtgtgtgtgt gtgtgtgtgt
     1921 gtgtgtgtgt gttgggggtg gattttgtta gttcagttga ctggttttat ttttgtagca
     1981 tgaatcagga ttgtgcttca ttgaacttgc agttaacttg aattgtaggt ggtttttatg
     2041 ctgctgaggt aagcttggtt gaggtaatca gttccttttc ctctcccaca agccacagcg
     2101 gctgctcctt gccatgtact ggagtcaaat ccctctgcat ctcagttggt agctatttag
     2161 ttgtatttaa aaacaaaacc cgaggaggtt agtgacgttt taaaggttat tacactttac
     2221 tttggagcac tttacgagac aatgtacaga ctcattcgtt gtatttctta gacttgcttt
     2281 tacacatgac atgctgtgct gtgggagatc tgcgcttatg atgtctagat agacagcttc
     2341 cattaaaagt gttttagctg catgtacagt tttaaaggga acataaacac atagggattt
     2401 tcctaagcac aacggtgagt tttcagagca cccaggaaac attgaggagg cacagcacca
     2461 tggcaaactt cacggaggag cagaatgaga gggtgggctg gtccagcctg tggtcatcct
     2521 gctgattcaa acatcgttac caacttagag tggggggacc accactctgc agtggtgcgg
     2581 tatgcacgga attgcgcagt tttttctcat ggcttttttt gtgaggtagg tatcatatat
     2641 ttcctctcta aaggtgaaga aggccaagtt tccgagggac aaaaatcctg cccagagatt
     2701 ttggaatttg gcagagctgg gctccagaca tctgagatac agacacagat cttcccctgt
     2761 gccacctaga cccctcactc accttcaagc tgctatactc aaggggaact tcactacttc
     2821 acttcacata ttcttttttt gttctctctc tctctctctc tctctctctc tctctctttc
     2881 tcttttcctt tctgagacat catttcatga agctcaagta ggccttgaag ttgctatatg
     2941 tctgggaaag acatggagtt tctaaaagaa acaaacagca gacccagcct ttcaaatgga
     3001 actcaaaaat atgacgatga atatgaattt gaatttataa ggcaagtgac ttacagttac
     3061 tgagtgctca atacagctga atggggggtc ttaccccagc agctttggaa gttcctagca
     3121 attcagctga tcagtagtag ggccttttgc ctcagggctt gcctcagcag agtaagttgt
     3181 gaacaaactc aggtaagtct tccacagtga agagacgata aaccctggtc tgagcttaga
     3241 ttaactgtga tagatcaggc tttggatttc tcattctttt tctttagttg tctgccagtg
     3301 ctggtgcatc cagaaccttc atcagcttct cagttaccca tggtacagac agaacagcca
     3361 gcaggagcgg aactgcagac tgaaggcaag aggccttctg actgtcctgg gctaaggcag
     3421 tatcttaact cagttggaca gcaccttttc ggaattttac tgctttctga gccactggga
     3481 aaaacaagcc tgggttcctt caattacaga aacccaagtt agtttgcaag aattgctaag
     3541 gttttaccca accctgaggt ttttttattg tctgtccttg ttgcccctcc cactctccca
     3601 tatacaagta tagttggaag agcccagcca acggcataac tattgtctgg tctccagtat
     3661 tactttacat ttgctttgtt agctcttttc ttaaaatggg tgtctgatgc tctctggctt
     3721 cgtgatcagg aattgggatg ttggaaattt gtttgcaaca ccaaacacct gggaaatcct
     3781 gattttgatg ccatttgagg caattgcaat ggtgttgtaa ttcaccagct gcttaaatag
     3841 ctttagggac tagtgaacac tatttgccac attatgttaa ggtcactgca tatgttagcc
     3901 acctacctct ttgatttcta atttatattt agcaaaggta aatatgtctt tgtccgttag
     3961 gatattagta gatattagca gtacattgaa atgcattttg ttttccattg ccaatgtaaa
     4021 ctgaatttta aaggccgata ttaatacaga tgttgaaagt tcaactttca ggaaagacag
     4081 cgttgtgaat atcgatgcat actggtagct tttgagtctt cttttgtgac tctagttgaa
     4141 cttggtttca catctgtgtt cttgcttatg tgcagttgaa ggtactgtct tctggttcat
     4201 aggcagctac acttggggag tgctctggga agactgcaga gccaacatga acagccatgg
     4261 gggaggggac attgaatcgt agctctcttt acactggata atctggtcag actacagttt
     4321 acacatcact ttaactattt taattatata tacattttga aagttttagg aaaaaacact
     4381 atggtgcaac attaaggaat ttaggtataa aattgcacat tgcctattat tctgtcattt
     4441 cttgatgggg aaaacaccac tactaaccac tgctgactga cataatcaga aaagttttcc
     4501 ttctagctaa taggatacat gaaagagata agaaaatatt tgttgttgtt aaaaaacaaa
     4561 aaagagtgaa gagaaatttc aaatagtttg cagcagtaat atttaaattt aatacatgtt
     4621 tgaatatcct caggaaggct aacaatacaa attcctgggc ccctgggtca atggttggat
     4681 gcaggaatgt ttatttctgt tgagtatttt gcctgattct ggttcagatg gtccccagag
     4741 cacagttaca agaaacactc ctgtagaaaa taagaatatc atttaaacac tgtttgcgtt
     4801 atcttaaagt agttgtgtgt taggagccaa tggtgataca caatgaaagg aagtctccat
     4861 gatgggtgcc ttctggttgg tttgtatgct ggtgcagatt tggccagcac cagctttact
     4921 ttcttttcac tggtgaagtc tgatgaacca tgtggtttca cagtaggggt caacgaatga
     4981 ctcactaatt gtaagtcatg acttccacaa ggctaattag tatagtattt tttcctgcag
     5041 atgtctctat agggcatctc ttcattatat gtaatttcct ggggagagag ggggaaatgt
     5101 aaaggctcat ctgattccta attctctgct cagaccagtt gttcagctga agcatgaagt
     5161 gaaataagat aatctttaaa tcttcgtact tttgttggtg acagagatat ttaatttctt
     5221 tgatctttgc tttgtttaca tgagaatgta taggtataga tcacaaacat ttccacctgc
     5281 ttgctatttt attctgtcat gatttttatt tgacttcaaa ttactaatag tttcaaattt
     5341 atttccataa ccataatttt gaggaactga acttcaactc cattgaagac acaactttta
     5401 taataataaa aatatcaaag cacatgtttg ttatcgcaaa taaatgttag tacacttctt
     5461 agctatctat aggtacttgt catttgtaat taaaattaat ttattttaaa atggcaccta
     5521 gcctttaaat gaatgaaaag cttttaattt gaggttgtaa catttaaata tcaaaagtat
     5581 gtttatttgt taatattctt attacaacca agaaaagagc taccaataag aaaatgaata
     5641 aatgtttact atttctaaa
//
LOCUS       NM_001436617            2835 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 7, mRNA.
ACCESSION   NM_001436617
VERSION     NM_001436617.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2835)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2835)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2835)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1584371.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000016.1  73925338-73925527
            191-379             JAXUCZ010000016.1  73925683-73925871
            380-459             JAXUCZ010000016.1  73926790-73926869
            460-515             JAXUCZ010000016.1  73927485-73927540
            516-594             JAXUCZ010000016.1  73929777-73929855
            595-671             JAXUCZ010000016.1  73930126-73930202
            672-849             JAXUCZ010000016.1  73931687-73931864
            850-915             JAXUCZ010000016.1  73932826-73932891
            916-987             JAXUCZ010000016.1  73934031-73934102
            988-1212            JAXUCZ010000016.1  73934279-73934503
            1213-1294           JAXUCZ010000016.1  73935273-73935354
            1295-1431           JAXUCZ010000016.1  73939574-73939710
            1432-1621           JAXUCZ010000016.1  73941664-73941853
            1622-1717           JAXUCZ010000016.1  73946164-73946259
            1718-1913           JAXUCZ010000016.1  73947426-73947621
            1914-2004           JAXUCZ010000016.1  73957828-73957918
            2005-2221           JAXUCZ010000016.1  73958685-73958901
            2222-2308           JAXUCZ010000016.1  73973622-73973708
            2309-2423           JAXUCZ010000016.1  73974416-73974530
            2424-2586           JAXUCZ010000016.1  73981312-73981474
            2587-2640           JAXUCZ010000016.1  73983410-73983463
            2641-2835           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2835
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..190
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            191..379
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            380..459
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            460..515
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            516..594
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            595..671
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            672..849
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            850..915
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            916..987
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1212
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1019..1021
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="upstream in-frame stop codon"
     CDS             1187..2653
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 6 is encoded by transcript variant 7; a
                     disintegrin and metalloprotease domain (ADAM) 5; tMDC II;
                     a disintegrin and metalloprotease domain 5; disintegrin
                     and metalloproteinase domain-containing protein 5;
                     transmembrane metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein II; a disintegrin and
                     metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 6"
                     /protein_id="NP_001423546.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MTHYINIGRFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLE
                     SYSVIVLQLLSIGIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLS
                     TQDLECLQDLPMERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRL
                     KSKAVCGSGECCGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCD
                     SGQAFCYSGLCMTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSL
                     CGKLVCTWPFKRLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETF
                     VKDGTICGPDMFCLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPY
                     CESVKGQFGSIDDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIK
                     QSKLSRLCGRERSEGTSCITEDSVSNTKMTTNEGSTLH"
     misc_feature    <1214..1525
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    <1214..1525
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1586..1810
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1586..1810
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1820..2251
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1820..2251
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            1213..1294
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1431
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1621
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1717
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1913
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2004
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2221
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2308
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2423
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2586
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2640
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2835
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaatgctt tgaaggtctg tgtttgacca atgagtattt aggggatgtc ccgcatgcag
       61 ctgtgaaaac aacaaaccag gttagcaaca ttgttgttgt tgttgttgtt gttgttctcc
      121 gttgttggga cagtttgccc aagtatcctg gaagacgtgt ggctgccatc agtaacctga
      181 acattttcat ccctttctgt gctggtttcc ttagcgacaa ccctgcaggt tcagctgcgg
      241 gagcttccgt tactggccac aacgccctcc ccacctgcct ggccagatgc tcctcagcta
      301 agctccagga ccaccaaggg agccatgttc ctccttcttt tgctggttgt gcatcttaat
      361 gggctgcagg caggccaaca tcctcagaaa accatcctgc aaacaactgt tcctgaaaag
      421 atctcatcac cagatgtgga aacagatcca gaaaaccata tggcttatct tattacaata
      481 aatgaaaacc cccatttcat ccatcttaaa aagcaatcgt ttataacttc aactgcagtg
      541 agttatacat atgacagaca agatgttcgg cattctcagt ctttgtcatc tctgaaaaat
      601 tgcaattaca acggatacgt tgcaggtttt ccaaattcta tcgtgtcgct caccgtttgc
      661 tcaggactca ggggaatgat acaatttgaa aatgtctcct atggaatcga acctgtggaa
      721 accctgtcag gatttataca cgtgatctat gagaacacaa atcagcaagc taagattcct
      781 gacttaggag agaatcagac gtacagttgg tctgatgaat tagattatca attccgaagc
      841 aacatgaaga aatccggatt tgccgtgtta cggccacggt acattaagac ggatatcgtc
      901 gtggataaaa agctgtttga ttacatgggc tccgacacta gggtcgtgct acagaaagtc
      961 attcagatca tcggtttcat taacactatg ttctccaagt tgaaactgac ggttttaata
     1021 aattccgttg aaatctggtc gaaggaaaac agaattgatt tcccagaggc acctgaaaac
     1081 ttactggtcc agtttttaca ttggaaacat aagtatagac cgcagcacat ttcatactta
     1141 ctggcgtaag caccataatt ctgtacctat agcatggata ggtcaaatga cacactatat
     1201 taatatcgga agatttgtgg agcatcctgc ttccacggga gccctctatc cggggaatct
     1261 gtgcaaaccg atctatggtg ctgccattgc cctgtaccct aaaggtttgt cactagagtc
     1321 ctacagcgtc atcgtcctac aactactgag catcggtata ggcttaacct atgacaacgc
     1381 tgacagctgc cactgtacag gagacgtctg cctgatgacg cccaaggcaa tatattctgg
     1441 gggtgtgaag gacttcagta cttgtagctt ggatgacttc aaatacctgt caacacaaga
     1501 ccttgaatgt ctccaggact tgcctatgga aagacaaaag aagaagcctt ccaggccaag
     1561 gagaatctgt ggcaacggga tattggaaat gaacgagcag tgtgactgtg gcactttgaa
     1621 gaattgtaca cacaaaaaat gctgtgaccc catgtcgtgc cgactgaagt ccaaagccgt
     1681 gtgtggctcc ggggagtgct gtggtcagga ctgcaaggta aaaccggtta atgtactctg
     1741 tagaaagtcg aagaatgaat gtgactttga ggagtactgt aacggaaatg acgcttactg
     1801 tgtccctgac acgttcgcac gcaacgggca gtactgcgac tcagggcaag ccttctgcta
     1861 cagtggtctt tgtatgacga gtaataatca atgcatgaac ttgctcggga aatatgtgag
     1921 aggagcttcc ttcgcatgct atgaagagtt caattccaga aacgatagat ttggcaactg
     1981 tattagaaag ttttgtagtt tcgaaaattc tctctgtggg aagttggtct gtacctggcc
     2041 attcaagagg ctgctcatga aagacaatat gtctgcggct tatggacaaa tccgagacga
     2101 tttatgcatc tctctgtata aaggagggag gccacttaag acaacattgt caacatattc
     2161 cgatatgtca gaaagagacg aaacatttgt aaaagacggc acaatctgtg gtcctgatat
     2221 gttttgtttg gaaacacagt gcaaagaaac gagatttttg gtggattttc aacagtgcaa
     2281 tacttcccga gattgcaatg accatggggt ttgcaacaac tttaatcatt gtcattgtga
     2341 taaaggatat aaccctccct attgtgagtc agtaaaagga cagtttggaa gcattgatga
     2401 cggccacaaa tattacattg acgaagggaa aagcgctaag cagcagaatc gtggtattca
     2461 cccaaagcag caactccagc ttattctgta tataacgctg cccttgatta tgattatctc
     2521 ggctgtattt ataaagcaaa gcaaactgag tcggctatgc ggcagagaaa gaagcgaagg
     2581 caccagctgt ataacagaag acagtgtgag taacaccaag atgaccacca acgaaggaag
     2641 cacccttcac taaccacctc aagtgttgcc acccaaaaag aagatagtct ggattaacca
     2701 cgggaaactg gcattttgag caagaggaag gggaaaaaac cacccccaaa ccaacccaca
     2761 gcttctctcc cacttctgca gagataaatg aggactctaa accatgaact aataaatcag
     2821 cggtggctga acaaa
//
LOCUS       NM_001436593            1104 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus clathrin, light chain A (Clta), transcript
            variant 3, mRNA.
ACCESSION   NM_001436593 XM_006238104
VERSION     NM_001436593.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Li,H., Alavian,K.N., Lazrove,E., Mehta,N., Jones,A., Zhang,P.,
            Licznerski,P., Graham,M., Uo,T., Guo,J., Rahner,C., Duman,R.S.,
            Morrison,R.S. and Jonas,E.A.
  TITLE     A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics
            during endocytosis
  JOURNAL   Nat Cell Biol 15 (7), 773-785 (2013)
   PUBMED   23792689
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1104)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1104)
  AUTHORS   Mettlen,M., Loerke,D., Yarar,D., Danuser,G. and Schmid,S.L.
  TITLE     Cargo- and adaptor-specific mechanisms regulate clathrin-mediated
            endocytosis
  JOURNAL   J Cell Biol 188 (6), 919-933 (2010)
   PUBMED   20231386
  REMARK    GeneRIF: The results underscore the highly dynamic and
            cargo-responsive nature of CCP assembly and suggest that the
            observed heterogeneity is, in part, related to compositional
            differences (e.g., cargo and adaptors) between CCPs.
REFERENCE   6  (bases 1 to 1104)
  AUTHORS   Drake,M.T., Downs,M.A. and Traub,L.M.
  TITLE     Epsin binds to clathrin by associating directly with the
            clathrin-terminal domain. Evidence for cooperative binding through
            two discrete sites
  JOURNAL   J Biol Chem 275 (9), 6479-6489 (2000)
   PUBMED   10692452
REFERENCE   7  (bases 1 to 1104)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   8  (bases 1 to 1104)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   9  (bases 1 to 1104)
  AUTHORS   Kirchhausen,T., Scarmato,P., Harrison,S.C., Monroe,J.J., Chow,E.P.,
            Mattaliano,R.J., Ramachandran,K.L., Smart,J.E., Ahn,A.H. and
            Brosius,J.
  TITLE     Clathrin light chains LCA and LCB are similar, polymorphic, and
            share repeated heptad motifs
  JOURNAL   Science 236 (4799), 320-324 (1987)
   PUBMED   3563513
REFERENCE   10 (bases 1 to 1104)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238104.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19260.1, FQ213766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000005.1  63041212-63041551
            341-378             JAXUCZ010000005.1  63047169-63047206
            379-496             JAXUCZ010000005.1  63048195-63048312
            497-608             JAXUCZ010000005.1  63052248-63052359
            609-662             JAXUCZ010000005.1  63056566-63056619
            663-1104            JAXUCZ010000005.1  63058782-63059223
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1104
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light chain A"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
     exon            1..340
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..834
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     clathrin, light polypeptide (Lca); clathrin, light chain
                     (Lca); lca"
                     /codon_start=1
                     /product="clathrin light chain A isoform 3"
                     /protein_id="NP_001423522.1"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKAS
                     NRVADEAFYKQPFADVIGYVAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKD
                     VSRMRSVLISLKQAPLVH"
     misc_feature    187..831
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     misc_feature    187..831
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     exon            341..378
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..608
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..662
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..1104
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctcctc tccgctcgtc ctccggtagc agccgccagc acagtgtccg ctgctgggcg
       61 gggtgtcggc ggatcggtcg gttggtttcg gcttcggtgt cgctgcgttt gagttgggcc
      121 gtcatggctg agttggatcc atttggcgct cccgccggtg cgcccggtgg ccccgcgctc
      181 gggaacgggg tggcgggcgc cggcgaggaa gacccggccg cggccttctt ggcgcagcag
      241 gagagtgaga ttgcgggcat agagaacgac gaggccttcg ccatcctaga cggcggcgcc
      301 cccgggccgc aggcacacgg cgagccgccg gggggtcctg atgcggttga tggagtgatg
      361 aatggcgaat actaccagga gagcaatggt ccaacagaca gttacgcagc catttcagaa
      421 gtggatcggt tgcagtcaga gcctgaaagt atccgtaagt ggagagaaga gcagacagag
      481 cgcctggaag ccctcgatgc caattctcgg aagcaggaag cagagtggaa agaaaaggcc
      541 gtgaaggagc tggaagagtg gtacgcaagg caggacgagc agctacagaa gacaaaagcc
      601 agcaacaggg tggcagatga agctttctac aaacaaccct tcgctgacgt gattggttat
      661 gtggcagcag aagaagcctt tgtaaacgac attgacgagt catccccagg cactgagtgg
      721 gagcgggtgg cccgcctgtg tgactttaac cccaagtcca gcaaacaggc caaagatgtc
      781 tctcgcatgc gctcagtcct catctccctg aagcaggcgc ccctggtgca ttgaagagcc
      841 accctgtgga aacactacgt ctccgatctt aatcctactc agtgaagctg ttcacgcaat
      901 tggattaatt atgccgagtt cttttggacc aaaccttttg tctttagagt tgatcattgt
      961 ttgtgattgc atgtttcctt caactgtgtt ctccctggca ttcagagaag agagaggaag
     1021 aggaagggag gggagctccc aacagtagcc tcaacctgtg cttttgtgca ttattctgag
     1081 aataaatttc tgtttcaaac aata
//
LOCUS       NM_001436611            5638 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 9, mRNA.
ACCESSION   NM_001436611
VERSION     NM_001436611.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5638)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5638)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5638)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5638)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5638)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5638)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5638)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5638)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5638)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5638)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2043703.1,
                                           SRR26360194.2450395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-235             JAXUCZ010000005.1  60609743-60609789   c
            236-502             JAXUCZ010000005.1  60609265-60609531   c
            503-562             JAXUCZ010000005.1  60607510-60607569   c
            563-789             JAXUCZ010000005.1  60605329-60605555   c
            790-893             JAXUCZ010000005.1  60599244-60599347   c
            894-5638            JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5638
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    62..64
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            189..235
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1048
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform b is encoded by transcript variant 9;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform b"
                     /protein_id="NP_001423540.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEVA
                     ESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKIS
                     MKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGE
                     KVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLES
                     QAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    <236..361
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    <236..361
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    509..814
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    509..814
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    order(791..793,797..799,803..811)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(791..793,797..799,803..811)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    797..799
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    797..799
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    866..1039
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    866..1039
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            236..502
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            503..562
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            563..789
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            790..893
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            894..5638
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagta cagttgaaag cggagtgtaa caagagatat gtcaacgtta agcagatggg
      241 ggtcaatccc accagcattg acgaagtcgt cattgggaag gaccgggaga tgaagctgct
      301 gcctggtcag gttctccaca tggtgaatga actttatcca tacatggtgg agtttgagga
      361 ggtggcagag agccctaacg taacacagag gaagagaaag aggccagact gtgatagtca
      421 ggagatggaa gctgaggctg gggccagccc cagccagtgc tctgtgtccc ctaagacggg
      481 caagcatgga gccgccaagg aggaatcact gggccactgg agtcaaggct tgaagatatc
      541 tatgaaagac cccaaaatgc aggtttataa ggatgatcag gtggtggtga ttaaggataa
      601 ataccccaag gcccggcacc actggctggt cttaccatgg gcctccattt ccagtctgaa
      661 ggttgtgacc agtgaacacc tcgaacttct caaacacatg cacgcagtag gggaaaaggt
      721 gatagcagat tttactggat ccagcaaact gcgcttccga ctgggttacc atgccattcc
      781 cagcatgagc catgtacatc ttcatgtgat cagccaggat tttgattctc cttgccttaa
      841 aaacaaaaag cattggaatt ctttcaatac agaatatttt ctggagtcac aagctgtgat
      901 caagatggtt caggaagctg gcagagtgac tgttaaagat gggacttgcg aactcttgaa
      961 gctgcctctc cgttgccatg agtgtcagca gctgctgcct tccatcccac agctgaagga
     1021 gcacctcagg aagcactggg gcgggtgaca ctcgccttgg tgaccgagtg cagtgctagc
     1081 atcattctgc attgcctgcg ctccgttcag tcctgaacta aagcatgcag ctcttcaaaa
     1141 caaagcttat tattcttgag tgaccacaca gggtgactct gggtcaggaa ctgggaatat
     1201 gggtttgtat ggtatatttt ctggtaatgg aggatgagac atgcctgatc actcttccca
     1261 agaccatgtc aggcctgact aataagaggg cagagccagc ttgaggttca aatacaagat
     1321 gtagaagcag aggactggta atgtatttgt tcctaccctt gcccctggat catgttctat
     1381 ctttttatca agatagctga ggttctgagg gggcctggtt cctgctctat gatattcctc
     1441 ttccctccat gaggaggctt tcaatctact gtaccaggct gagtgcctgg gtgaacatat
     1501 gtggcagtca tctgcacaga gagatacttt gtgtatgact gtgccaggga actggaagtg
     1561 gtaatattgg gcacagtatg ttaacagtac agcctgtgtc gagggcaaac tggggtaatg
     1621 tgaactgcca gtaaacagta catcctctgc tgagggcagc ctggggcagt gtgaactgcc
     1681 agtaaacagt acagcctgtg ctgagggcag catggaacag tgtgaactgt tagtgaacag
     1741 tagtctgttc tgagggcagc cttgtacagt gatgtcagtt aacagtgcag tctgttgagg
     1801 gcatcctggg atggtgtgaa ctgtcagtta acagtgcagt ctgttgaggg catcctggga
     1861 tggtgtgaac tgtcagttaa cagtgcagtc tgttgagggc atcctgggat ggtgtgaact
     1921 gtcagttaac agtgcagtct gttgagggca tcctgggatg gtgtgaactg tcagttaaca
     1981 gtgcagtctg ttgagggcat cctgggatgg tgtgaactgt cagttaacag tgcagtctgt
     2041 gttgagggca gcctgggcag tgtgtattgt tagcttcagg cagattttac ggaggcttca
     2101 gccactgctc ttgagaatta cagaacattt aactaaactt cggataatgt atcttagaaa
     2161 aacagatgtt gcaaaatagt tcatttactt tccacctgat acaatatagt ttagcacatc
     2221 agtattaaaa tgagtatttg ctgtaaacta ctaggagtgt ctgtatcaga cagcgtaaga
     2281 atgtcaggta taatgagaaa catttgggga atgaggtgac catgcttaca ttcttccttc
     2341 tgcccaaaat agattttttt aagactgggg tgagtgcatg ctgcccttcc taggacctga
     2401 gttttgttcc cggcatccat attaggtggc tcacagctgc ctgtagctcc agggatcctg
     2461 cacctgcttc ttgacctctg tgggcactgc attcaagtac acaaacctga atacagacac
     2521 acattcacac ataattaaat ctgtaaaaat cagatctcgg gctggagaga tggctcagtg
     2581 gttaagagct cctccagagg tcctgagttc aattcccagc aaccacatgg tggctcacaa
     2641 ccatctgtaa tgggatctga tgccctcttc tggtatgcat ggagacagcc acagtgcact
     2701 tatacataaa taaatacata aataaaaaaa atagatctct tagaggaaaa atgtcaataa
     2761 tgactggcag gaagcaggta ttgaggtatt gaggtttatt cattccctag ccctcctctc
     2821 cgaaatgggc ttttatcacc atggggaaga agactgtctg gactctggat tacttgacag
     2881 acatgtcatt gtacaattag ttgaagcttt ccttcagagt cagagggagg gatgttggga
     2941 gactgcaaag tagaagaaag ccagccacat ttaaagctag gcacagtggc aaattctctt
     3001 gcaatcccaa atttaggagg tggtagatcc aggagggcca ggcattccag gttatccttg
     3061 tctatatggt gaacttgagg tctggactac atgagaccct atgtcacaga agcaaataaa
     3121 taaaagattt aaaaagggga aataaaattc tatctaaggt accaaagcat attatttggc
     3181 ccatcatggc caggcaagac cagttgttat caaagcagct gttatggctg gaatctggga
     3241 taactcaggc tcatgttctg gagcgtgggt cctttccttg cagtgttgtt tagatgactg
     3301 tgaagccatt agggtgaagc cgggctggca gaagtaggtg tctaggagca ggcaggccct
     3361 gaaggctata ccctttcccg gctcctggtg ggctgcttta cctcctgtga acaggacacc
     3421 catctctgct actatggact gacactgtgt gtgtgtgcgc gtgcgcacac gcgcgcgcgt
     3481 gtgtacacaa gaggacaatt tctggaagtc aattgtctcc accatattgg ccctagggat
     3541 tgactcacta gcttgactca gtgtctttac ccactgagtt ccagtaagtc agaagtactc
     3601 ttttaagaaa tagcaactta gggcctggag tgacggctca ggggttaaga gcactgactg
     3661 ctcttccaga ggtcctgagt tcaattccca gcaaccacat ggtggctcac aaccatctgt
     3721 aacaggatcc gatttacata taataaataa ataaatctta aaaaaaagaa ataacttaat
     3781 tctcaagtac gtacacacac acacacacac acacacacac acacacacac acacacactc
     3841 tctctctctc tctcctacct tatcccaagc taccctaaac tcaccatgta gactaggatg
     3901 accttgaact tgctgagatc tgccagtcca gagccagggt actgggattc aagtatccca
     3961 ccaaagagga aaataagcaa atgtacaagg attagataga cattgcccat aattaattaa
     4021 aattcagtgt tttctgagag tggaaatatt gtcatgaaat attccctttt gcagcaatgc
     4081 tcagatctgc ctctttagaa tggtctttct ttttgaatgt tgctaatggt gtactggctg
     4141 gttttgtgta tcaatttggc acacgctaga gtcatcagag aggaaggacc ttcagttgag
     4201 aaaatgcctc catgagctcc agctgtaaga cattttcata attagggatc agtggggcta
     4261 gcgccattgt gggtggtacc actcctggac tggtggtcct gggtcctata agaaggcagg
     4321 ctgagcaagc caggggaagc aagccagtgt ggggtggggg caccccactc atggtctctg
     4381 cctcagctcc tgtctccagg ttcctgctct gtctgagttc ctgtcctggc tgcctttggt
     4441 ggtgaacatg actgctgtgt gattgcctgt ctgtcactcg ggctttatgg tatcccaggg
     4501 cattcagaat tgggaggtgc ataatggagt gttatttaag ccataaataa tgaacagaat
     4561 ggaattgtgt cctttgccag aagacagata ccctggaggt catcctgtga aacgcaatca
     4621 gccagactca gaacagtcac ctcatactgg tatttcaaag gtcttggctc tcctgactct
     4681 atgcccatcg tgaggcagag catagcagag gttgaagcat gtacaaagcc ttcttggcac
     4741 atgggacaaa gaggcagaga caccactttg ttctgagatt ggtcttactg tgtagcaaag
     4801 actgacctgg aattcatgca gctcagtttg gtcttgagtt caagacccaa ctgccttagc
     4861 agttctgggt gtgtgctagg aagtgttctc agataatgtt ttcagagcac gagacacctt
     4921 catgtgtagg ctatcatgag tcaactaacc tttctgtggc tggaccctgc aggtaagggg
     4981 tggagcgcag ggcagaggag agacttctgg cactctaagg agcctgtgga ccacctagat
     5041 tcttacctgc tgctaacatt tccacaccac aggcaccctc tagcctatgg cagctgggaa
     5101 cttatttttg ctttcaagaa cccagtgata ggtctgtttc tcaaatacag ctgatgtggc
     5161 tgaccttgag tgaaaggaga ctgaaggttt taggagaccc cagtatgtag acctgactga
     5221 acttgcccct gaagctgaca gcccattgca tactcttcac atgaatgaga aaaaggtgcc
     5281 tgttgtatgt ggaggccttt aacccagatc ccctgaggcc ggagcccatg tgaggcacaa
     5341 ctacatgacc acatagggtg atgtgatggt ttgcatattt ggcccaggga gtggcactat
     5401 tagaaggtgt ggccttgttg gaggaagtgt gtcactgtgg gggggtgggc ttggagaccc
     5461 tcctcctagc tgcctgggga tgctcagtct gttcctggct tcctttggtt gaagatgtag
     5521 aactcagctc ctcctgcacc aggcctgcct ggatgctgcc atgctcctgc cttgataatg
     5581 gactaaacct ctgatctgta agccagccct aattaaatgt tgtcctttat aaaactta
//
LOCUS       NM_001106634            1398 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus short chain dehydrogenase/reductase family 16C,
            member 5 (Sdr16c5), transcript variant 2, mRNA.
ACCESSION   NM_001106634 XM_001069656 XM_216325
VERSION     NM_001106634.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Takahashi,Y., Moiseyev,G., Farjo,K. and Ma,J.X.
  TITLE     Characterization of key residues and membrane association domains
            in retinol dehydrogenase 10
  JOURNAL   Biochem J 419 (1), 113-122 (2009)
   PUBMED   19102727
REFERENCE   2  (bases 1 to 1398)
  AUTHORS   Lee,S.A., Belyaeva,O.V. and Kedishvili,N.Y.
  TITLE     Biochemical characterization of human epidermal retinol
            dehydrogenase 2
  JOURNAL   Chem Biol Interact 178 (1-3), 182-187 (2009)
   PUBMED   18926804
REFERENCE   3  (bases 1 to 1398)
  AUTHORS   Markova,N.G., Pinkas-Sarafova,A. and Simon,M.
  TITLE     A metabolic enzyme of the short-chain dehydrogenase/reductase
            superfamily may moonlight in the nucleus as a repressor of promoter
            activity
  JOURNAL   J Invest Dermatol 126 (9), 2019-2031 (2006)
   PUBMED   16691198
REFERENCE   4  (bases 1 to 1398)
  AUTHORS   Matsuzaka,Y., Okamoto,K., Tsuji,H., Mabuchi,T., Ozawa,A., Tamiya,G.
            and Inoko,H.
  TITLE     Identification of the hRDH-E2 gene, a novel member of the SDR
            family, and its increased expression in psoriatic lesion
  JOURNAL   Biochem Biophys Res Commun 297 (5), 1171-1180 (2002)
   PUBMED   12372410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216325.4, XM_001069656.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMN06621351
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..1398
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="short chain dehydrogenase/reductase family 16C,
                     member 5"
                     /db_xref="GeneID:297805"
                     /db_xref="RGD:1565999"
     exon            1..552
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    112..114
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="upstream in-frame stop codon"
     CDS             220..1149
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /EC_number="1.1.1.105"
                     /note="epidermal retinal dehydrogenase 2; retinal short
                     chain dehydrogenase reductase 2"
                     /codon_start=1
                     /product="epidermal retinol dehydrogenase 2"
                     /protein_id="NP_001100104.1"
                     /db_xref="GeneID:297805"
                     /db_xref="RGD:1565999"
                     /translation="MPCNLESAKDLLVFLGKSLLSILEALLSHVISKPRKNVAGEVVL
                     ITGAGSGLGRLLALQFARLGSVLVLWDVNKETNEETRQIAQEAGAIRVHAYTCDCSQR
                     EEVYRVADQVKKEVGDVSILINNAGIVTGRKFLDCPDDLMEKSLDVNFKAHLWMYKAF
                     LPAMIANNHGHLVCISSSAGLIGVNGLSDYCASKFAALGFAESMFVETLAQKQRGIKT
                     TIVCPFFIKTGMFEGCTTKCPNLLPILDPEYAVRKIVDAILQEQLYLYMPKFLYFIMF
                     LKSFLPIKTGILIADYLGLFHVMDGFTGQKKKS"
     misc_feature    343..1071
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="human 17-beta-hydroxysteroid dehydrogenase XI-like,
                     classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c;
                     cd05339"
                     /db_xref="CDD:187598"
     misc_feature    343..1071
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="human 17-beta-hydroxysteroid dehydrogenase XI-like,
                     classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c;
                     cd05339"
                     /db_xref="CDD:187598"
     misc_feature    order(358..360,364..375,430..438,508..516,592..600,
                     661..663,742..750,787..789,799..801,886..897,901..906)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187598"
     misc_feature    order(358..360,364..375,430..438,508..516,592..600,
                     661..663,742..750,787..789,799..801,886..897,901..906)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187598"
     misc_feature    order(523..525,535..537,631..636,643..648,655..657,
                     667..672,679..684,691..693,778..786,790..795,802..807,
                     814..819,823..831,835..840,904..912,1036..1041,1048..1050,
                     1060..1062)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(523..525,535..537,631..636,643..648,655..657,
                     667..672,679..684,691..693,778..786,790..795,802..807,
                     814..819,823..831,835..840,904..912,1036..1041,1048..1050,
                     1060..1062)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(664..666,748..750,787..789,799..801)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="active site"
                     /db_xref="CDD:187598"
     misc_feature    order(664..666,748..750,787..789,799..801)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="active site"
                     /db_xref="CDD:187598"
     misc_feature    order(691..693,700..702,829..831,838..840,856..858)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(691..693,700..702,829..831,838..840,856..858)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:187598"
     exon            553..684
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            685..784
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            785..929
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1055
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1398
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatgtcgtt atctgtgaca catagctggc atgcagatct gaatggaact tgagagccat
       61 gtgtagatat tgtgccagat atcgtacatc actgtggttc ctgcctgctc ctgagttcag
      121 tatcctcagc atctggaaag agcaactcta tcacattctt ttctttcaga aaagggaact
      181 gagaaaactc tctcttgctt taaaggtgtt ggccagaaca tgccttgcaa cctggaatca
      241 gcgaaggact tgcttgtttt cttagggaag tcactgttga gtattttgga ggctctactt
      301 tctcatgtca tctcaaaacc acggaagaat gttgctggcg aagtagtcct catcacaggt
      361 gctgggagtg gactcggaag gcttttagca ttgcagttcg cccgcctggg atcagtgctc
      421 gttctttggg atgtgaacaa ggagacaaat gaggagaccc gtcagatagc tcaggaagca
      481 ggagccatca gagtgcatgc ctacacctgt gactgcagcc agagggaaga agtatacaga
      541 gtggccgacc aggttaagaa agaagttggt gacgtctcta tcctcatcaa caatgctggc
      601 attgtaacag gcagaaagtt cctcgattgc ccagatgacc tcatggaaaa gtcacttgat
      661 gtcaatttca aagcacattt atggatgtat aaagcctttc tacctgccat gattgctaac
      721 aaccatggcc atttggtttg catttcaagt tcggctggat tgattggagt aaatgggctg
      781 tcagactatt gtgcaagtaa attcgcagcc cttggatttg cagaatctat gtttgtcgaa
      841 acacttgccc aaaaacaaag ggggatcaaa actactattg tgtgcccatt ctttataaaa
      901 actggaatgt ttgaaggttg cactactaag tgtcctaatc tgttaccaat tctggatcca
      961 gaatatgcag ttaggaaaat agtagatgct atccttcagg agcagctgta cttgtatatg
     1021 cccaagtttt tatacttcat aatgttttta aaaagcttct tgcccatcaa gacaggaata
     1081 cttatagctg actacctagg actctttcat gtgatggatg gcttcactgg tcaaaagaag
     1141 aaatcttaat gataacccct atgccctgtg ttttctgaga cccattgcta cgtcaggctt
     1201 acttcaaaga agaaaggtat ttctgtccga cagaacccaa aaacaaatat gttctactgt
     1261 ggaccatgat ccttccagtg tcatttgaat acaatgttac tgttttttct tttgttgtcg
     1321 ttgttgttgt tgaatgtatt ttttgtttag ttttggaaaa taaaagtagc tctttgtcat
     1381 tcccacttca acaactat
//
LOCUS       NM_001038599            1794 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1B2, mRNA.
ACCESSION   NM_001038599
VERSION     NM_001038599.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1794)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1794)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1794)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 20, 2007 this sequence version replaced NM_001038599.1.
            
            Transcript Variant: This variant (MOR-1B2) lacks several exons and
            contains an alternate terminal exon compared to variant MOR-1C2.
            The encoded isoform (1B2) is shorter than isoform 1C2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY309003.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-491               JAXUCZ010000001.1  45585983-45586473
            492-844             JAXUCZ010000001.1  45617450-45617802
            845-1365            JAXUCZ010000001.1  45618567-45619087
            1366-1794           JAXUCZ010000001.1  45627039-45627467
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1794
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1389
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1B2 is encoded by transcript variant
                     MOR-1B2; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1B2"
                     /protein_id="NP_001033688.2"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQEPQSVE
                     T"
     misc_feature    232..234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    298..300
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    319..321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    343..345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    364..366
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    406..480
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    520..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    628..696
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    703..705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    757..822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..966
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1039..1119
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1144..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1201..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1288..1362
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1296
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1315..1317
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1330..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1384..1386
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1794
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accaggagcc tcagtcagta
     1381 gagacatgat gtgaatgaac caactgatta aacaaggttt tctgaacact gaaatacaac
     1441 acaaatatag aggttactag agaaaatttg tagcctgaaa attcaattac ggaaaccaaa
     1501 tgagtgtgag tgtatacatt ttaaggcctc agagagattt tatttcatga ctaacaacat
     1561 gacccaaagc acctaaactg tggtgattag attacaaaga caattctaga gcctgggact
     1621 aaagaaatgt tagccctcac acagacaggc ctcacacttc agtaatggaa tgagcaaatt
     1681 agattagtga gaaagatgga ggaaagactc gaaatatttt catatcttcc tgtggaactc
     1741 cacaagaaaa ccaatagaat aaaccaacct gctggaccct tggtggctct tacc
//
LOCUS       NM_174864               2915 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus nicastrin (Ncstn), mRNA.
ACCESSION   NM_174864
VERSION     NM_174864.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Dursun,E. and Gezen-Ak,D.
  TITLE     Vitamin D receptor is present on the neuronal plasma membrane and
            is co-localized with amyloid precursor protein, ADAM10 or Nicastrin
  JOURNAL   PLoS One 12 (11), e0188605 (2017)
   PUBMED   29176823
  REMARK    GeneRIF: These results demonstrated the localization of VDR on the
            neuronal plasma membrane and the co-localization of VDR and APP or
            ADAM10 or Nicastrin and limited co-localization of VDR and PS1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Dries,D.R., Zhu,Y., Brooks,M.M., Forero,D.A., Adachi,M., Cenik,B.,
            West,J.M., Han,Y.H., Yu,C., Arbella,J., Nordin,A., Adolfsson,R.,
            Del-Favero,J., Lu,Q.R., Callaerts,P., Birnbaum,S.G. and Yu,G.
  TITLE     Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination
            and Schizophrenia with Compulsive Behavior
  JOURNAL   J Biol Chem 291 (22), 11647-11656 (2016)
   PUBMED   27008863
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Bai,X.C., Yan,C., Yang,G., Lu,P., Ma,D., Sun,L., Zhou,R.,
            Scheres,S.H.W. and Shi,Y.
  TITLE     An atomic structure of human gamma-secretase
  JOURNAL   Nature 525 (7568), 212-217 (2015)
   PUBMED   26280335
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Teranishi,Y., Inoue,M., Yamamoto,N.G., Kihara,T., Wiehager,B.,
            Ishikawa,T., Winblad,B., Schedin-Weiss,S., Frykman,S. and
            Tjernberg,L.O.
  TITLE     Proton myo-inositol cotransporter is a novel gamma-secretase
            associated protein that regulates Abeta production without
            affecting Notch cleavage
  JOURNAL   FEBS J 282 (17), 3438-3451 (2015)
   PUBMED   26094765
  REMARK    Review article
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Pasternak,S.H., Bagshaw,R.D., Guiral,M., Zhang,S., Ackerley,C.A.,
            Pak,B.J., Callahan,J.W. and Mahuran,D.J.
  TITLE     Presenilin-1, nicastrin, amyloid precursor protein, and
            gamma-secretase activity are co-localized in the lysosomal membrane
  JOURNAL   J Biol Chem 278 (29), 26687-26694 (2003)
   PUBMED   12736250
  REMARK    GeneRIF: experiments establish amyloid precursor protein,
            nicastrin, and presenilin-1 as resident lysosomal membrane proteins
            and indicate that gamma-secretase is a lysosomal protease
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Chen,F., Tandon,A., Sanjo,N., Gu,Y.J., Hasegawa,H., Arawaka,S.,
            Lee,F.J., Ruan,X., Mastrangelo,P., Erdebil,S., Wang,L.,
            Westaway,D., Mount,H.T., Yankner,B., Fraser,P.E. and St
            George-Hyslop,P.
  TITLE     Presenilin 1 and presenilin 2 have differential effects on the
            stability and maturation of nicastrin in Mammalian brain
  JOURNAL   J Biol Chem 278 (22), 19974-19979 (2003)
   PUBMED   12646573
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Lee,S.F., Shah,S., Li,H., Yu,C., Han,W. and Yu,G.
  TITLE     Mammalian APH-1 interacts with presenilin and nicastrin and is
            required for intramembrane proteolysis of amyloid-beta precursor
            protein and Notch
  JOURNAL   J Biol Chem 277 (47), 45013-45019 (2002)
   PUBMED   12297508
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Dermaut,B., Theuns,J., Sleegers,K., Hasegawa,H., Van den Broeck,M.,
            Vennekens,K., Corsmit,E., St George-Hyslop,P., Cruts,M., van
            Duijn,C.M. and Van Broeckhoven,C.
  TITLE     The gene encoding nicastrin, a major gamma-secretase component,
            modifies risk for familial early-onset Alzheimer disease in a Dutch
            population-based sample
  JOURNAL   Am J Hum Genet 70 (6), 1568-1574 (2002)
   PUBMED   11992262
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Leem,J.Y., Vijayan,S., Han,P., Cai,D., Machura,M., Lopes,K.O.,
            Veselits,M.L., Xu,H. and Thinakaran,G.
  TITLE     Presenilin 1 is required for maturation and cell surface
            accumulation of nicastrin
  JOURNAL   J Biol Chem 277 (21), 19236-19240 (2002)
   PUBMED   11943765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC074006.1 and AY101378.1.
            
            On Oct 8, 2005 this sequence version replaced NM_174864.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY101378.1, SRR8487231.45426.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BC074006.1         1-92
            93-1795             AY101378.1         1-1703
            1796-2915           BC074006.1         1911-3030
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2915
                     /gene="Ncstn"
                     /note="nicastrin"
                     /db_xref="GeneID:289231"
                     /db_xref="RGD:631418"
     exon            1..174
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2219
                     /gene="Ncstn"
                     /codon_start=1
                     /product="nicastrin precursor"
                     /protein_id="NP_777353.1"
                     /db_xref="GeneID:289231"
                     /db_xref="RGD:631418"
                     /translation="MATARGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLN
                     KTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDLKWVLTDGPNPPYMVLLEGKLF
                     TRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKK
                     TLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFS
                     HMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSGGLEPDVRVVV
                     AATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLPRNVMFVFFQGETF
                     DYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVKNQ
                     VEDLLVTLEQSGADTPQVVLSRLVQSQALPPSSLQRFLRARNISGVVLADHSGSFHNR
                     YYQSIYDTAENINVTYPESQSPEEDLNFVTDTAKALADVATVLARALYKLAGGTNFNN
                     SIQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSYLDDGPLQHYIAVSSPTNTTYVV
                     QYALANLTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTV
                     RLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFS
                     LIVTYCINAKADVLFVAPREPGAVSY"
     sig_peptide     93..194
                     /gene="Ncstn"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1)"
     mat_peptide     195..2216
                     /gene="Ncstn"
                     /product="Nicastrin. /id=PRO_0000019683"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGU6.1)"
     misc_feature    222..224
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    243..2051
                     /gene="Ncstn"
                     /note="M28 Zn-peptidase nicastrin, a main component of
                     gamma-secretase complex; Region: M28_Nicastrin; cd03881"
                     /db_xref="CDD:349877"
     misc_feature    243..2051
                     /gene="Ncstn"
                     /note="M28 Zn-peptidase nicastrin, a main component of
                     gamma-secretase complex; Region: M28_Nicastrin; cd03881"
                     /db_xref="CDD:349877"
     misc_feature    252..254
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    474..476
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    648..650
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    699..701
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    879..881
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1095..1109
                     /gene="Ncstn"
                     /note="DYIGS region; other site"
                     /db_xref="CDD:349877"
     misc_feature    1095..1109
                     /gene="Ncstn"
                     /note="DYIGS region; other site"
                     /db_xref="CDD:349877"
     misc_feature    1248..1250
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1392..1394
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1479..1481
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1611..1613
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1677..1679
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1773..1775
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1806..1808
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1827..1829
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1869..1871
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    1923..1925
                     /gene="Ncstn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGU6.1); glycosylation site"
     misc_feature    2097..2159
                     /gene="Ncstn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGU6.1);
                     transmembrane region"
     exon            175..279
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            280..403
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            404..525
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            526..671
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            672..822
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            823..932
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1085
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1190
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1268
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1441
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1544
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1640
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1728
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1883
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2096
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2891
                     /gene="Ncstn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgggcca cagagacgat gccagcggaa gcctagagag accgctaaga gactggaagg
       61 gacccgaggc ttccgcccag cggagaggca agatggctac ggctaggggc ggctctgggc
      121 ctgacccagg aagtcggggt ctccttcttc tgtctttttc cgtggtacta gcaggattgt
      181 gtgggggaaa ctcagtggag aggaagatct acattccctt aaataaaaca gctccttgtg
      241 tccgcctgct caatgccact catcagattg gctgccagtc ttcaattagt ggggatacag
      301 gggttatcca cgtagtggag aaagaagacg acctgaaatg ggtattgacg gatggcccca
      361 acccccctta catggttctg ctggagggca agctctttac cagagatata atggaaaagc
      421 tgaaggggga aaccagtaga atcgctggtc ttgccgtgac tctagccaag cccaattcaa
      481 cgtcaagctt ctctcctagc gtgcagtgcc caaatgatgg gtttggtatt tactccaact
      541 cctatgggcc agagtttgct cactgcaaaa aaacattgtg gaatgaactg ggcaatggct
      601 tggcttatga cgacttcagt ttccccatct ttcttcttga agatgagaac gaaaccaagg
      661 tcatcaagca gtgctatcaa gatcacaacc tgggtcagaa tggctctgca ccgagcttcc
      721 cactgtgtgc tatgcagctc ttctcacaca tgcacgccgt catcagcacc gccacctgca
      781 tgcgacgcag cttcatccag agcaccttca gcatcaaccc agaaatcgtc tgtgacccct
      841 tatccgacta caacgtatgg agcatgctta agcctataaa tacgtctggg ggattagaac
      901 ctgatgtcag ggttgtggtt gcagccacac ggctggatag ccggtccttc ttctggaatg
      961 tggccccagg ggcagaaagt gccgttgcct cctttgtcac tcagctggcc gcagctgaag
     1021 ctttgcacaa ggcacctgat gtgaccaccc taccccgaaa tgtgatgttt gtcttcttcc
     1081 agggggaaac ttttgactac attggcagct caaggatggt ctatgacatg gagaacggca
     1141 agtttcctgt gcggctagag aacattgact cctttgtgga gctggggcag gtggccctaa
     1201 ggacgtcact agaactctgg atgcacacag atcctatgtc tcagaaaaat gaatctgtga
     1261 agaaccaggt ggaggatctt ctggtcactc tggagcagag tggtgctgat acccctcaag
     1321 ttgtcctgag cagactagtc cagtcccagg cccttccacc atcatctcta caacgatttc
     1381 ttcgggctcg aaacatctct ggtgtggtct tggctgacca ctctggttcc ttccacaatc
     1441 ggtattacca gagcatttat gacactgctg agaacattaa cgtgacctat cctgagtcgc
     1501 agagcccaga agaggacctc aactttgtaa cagacactgc caaggcactg gcagatgttg
     1561 ccacagtgct ggcacgagct ttgtacaagc ttgcaggagg aaccaacttc aacaactcca
     1621 ttcaggctga tccccagaca gttacacgtc tgctctatgg gttcctggtc agagctaaca
     1681 actcatggtt tcagtctatc ctcagacatg atctgaggtc ctatttggat gatgggcctc
     1741 ttcaacacta catcgctgtc tccagcccta ccaacacgac ttacgttgtg cagtatgcct
     1801 tggcaaacct gactggcaag gtgaccaacc tcacccaaga gcagtgccag gatccaagta
     1861 aagtcccaaa tgaaagcaag gatttgtatg aatactcgtg ggtacaaggc ccttggaatt
     1921 ccaacaagac agagcggctc ccacggtgtg tgcgctccac agtacgactg gctagggcct
     1981 tgtcccccgc ctttgagctg agtcagtgga gctccacaga atactctacg tgggccgaga
     2041 gccgctggaa agatatccaa gctcggatat tcctcattgc cagcaaagaa cttgagttca
     2101 tcacgctgat cgtgggcttc agcatcctcg tcttttctct catcgtcact tattgtatca
     2161 acgccaaggc cgatgtcctt ttcgttgctc cccgagagcc aggagctgtg tcttactgaa
     2221 gaggactcca gctctccctg ccagctctga actttccttc ccaaaccagg tgtctgactg
     2281 ggaacaaacc actaatttgt cactggactg tctctgggcc tgcttagact gggattgaca
     2341 ggtagatgga aatgtgagtg gagagataac taagttgcct ccccttctca gccccccttt
     2401 cccattcgtt tttccttctc taataccagg gattacgaca gaggcctgct gctcctgtct
     2461 aactcccagt taccctctcc catcagccct ttctcgggat tcctcctgtc tttcatcctg
     2521 ccctgtactg ccctctgacc ccactgtcac ccgaccccca cagcctcctg tgttcagcca
     2581 cctgctgcac caggaagagg gtgtgaaaga ttgggcatcg gcatccaagc accctgaacc
     2641 tgagggaagg aatgggttcc ctggctgagc cagtgtctct ttctcactgt cctttctcca
     2701 ggcgtgcaga tggcatgtta gtgtgggcat gctgttaggt gggtatccca cctccagccc
     2761 acagtgctcg gatgtacttt ttattattaa actataatat ctatttttgt tgggcttttt
     2821 cttttttttc ttttttttct tttttttgta aatatataaa tagcaagttt cattaaaatt
     2881 atccaataca aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_001304738            2574 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1i2, mRNA.
ACCESSION   NM_001304738
VERSION     NM_001304738.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2574)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2574)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2574)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2574)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2574)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2574)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2574)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2574)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1i2) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1) is shorter
            than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU024652.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  45565371-45565459
            90-759              JAXUCZ010000001.1  45585804-45586473
            760-1112            JAXUCZ010000001.1  45617450-45617802
            1113-1633           JAXUCZ010000001.1  45618567-45619087
            1634-2574           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2574
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..89
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..759
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    260..262
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     CDS             476..1672
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant MOR-1i2;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_001291667.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     misc_feature    500..502
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    566..568
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    587..589
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    611..613
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    632..634
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    674..748
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    680..1516
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    680..1516
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    683..763
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    683..763
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    782..862
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    782..862
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    788..862
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(845..847,854..859,893..910,914..919,926..928,
                     1061..1063,1067..1081,1160..1162,1169..1177,1181..1189,
                     1193..1198,1352..1354,1361..1366,1370..1375,1382..1384,
                     1415..1420,1424..1432,1439..1441,1448..1453)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(845..847,854..859,893..910,914..919,926..928,
                     1061..1063,1067..1081,1160..1162,1169..1177,1181..1189,
                     1193..1198,1352..1354,1361..1366,1370..1375,1382..1384,
                     1415..1420,1424..1432,1439..1441,1448..1453)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    893..985
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    893..985
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    896..964
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    971..973
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1019..1087
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1019..1087
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1025..1090
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1160..1249
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1160..1249
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1160..1234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1292..1384
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1292..1384
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1307..1387
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1412..1483
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1418..1495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1418..1495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1469..1483
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1556..1630
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1562..1564
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1583..1585
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1598..1600
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1655..1657
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            760..1112
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1633
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..2574
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctt gcatggagac cgaccgaccg aggaggctga
      121 ctctctgatt gctttgcgca aaatccactc ctctcctccc tcctctctag cctctggatc
      181 cctcgcagcc cgcgcgctcc ctcccttcca cccagagagt ggcgctttgg gaagctagag
      241 atgcgcctct gtgtacttct aaggtgggag ggggctacaa gcagaggaga atatcagacg
      301 ctcagacgtt cccttctgcc tgccgctctt ctctggttcc actagggctg gtccatgtaa
      361 gaatctgacg gagcctaggg cagctgtgag aggaagaggc tggggcgcgt ggaacccgaa
      421 aagtctgagt gctctcagtt acagcctacc tagtccgcag caggccttca gcaccatgga
      481 cagcagcacc ggcccaggga acaccagcga ctgctcagac cccttagctc aggcaagttg
      541 ctccccagca cctggctcct ggctcaactt gtcccacgtt gatggcaacc agtccgatcc
      601 atgcggtctg aaccgcaccg ggcttggcgg gaacgacagc ctgtgccctc agaccggcag
      661 cccttccatg gtcacagcca ttaccatcat ggccctctac tctatcgtgt gtgtagtggg
      721 cctcttcgga aacttcctgg tcatgtatgt gattgtaaga tacaccaaaa tgaagactgc
      781 caccaacatc tacattttca accttgctct ggcagacgcc ttagcgacca gtacactgcc
      841 ctttcagagt gtcaactacc tgatgggaac atggcccttc ggaaccatcc tctgcaagat
      901 cgtgatctca atagattact acaacatgtt caccagcata ttcaccctct gcaccatgag
      961 cgtggaccgc tacattgctg tctgccaccc agtcaaagcc ctggatttcc gtaccccccg
     1021 aaatgccaaa atcgtcaacg tctgcaactg gatcctctct tctgccatcg gtctgcctgt
     1081 aatgttcatg gcaaccacaa aatacaggca ggggtccata gattgcaccc tcacgttctc
     1141 ccacccaacc tggtactggg agaacctgct caaaatctgt gtctttatct tcgctttcat
     1201 catgccggtc ctcatcatca ctgtgtgtta cggcctgatg atcttacgac tcaagagcgt
     1261 tcgcatgcta tcgggctcca aagaaaagga caggaatctg cgcaggatca cccggatggt
     1321 gctggtggtc gtggctgtat ttatcgtctg ctggaccccc atccacatct acgtcatcat
     1381 caaagcgctg atcacgattc cagaaaccac atttcagacc gtttcctggc acttctgcat
     1441 tgctttgggt tacacgaaca gctgcctgaa tccagttctt tacgccttcc tggatgaaaa
     1501 cttcaagcga tgcttcagag agttctgcat cccaacctcg tccacgatcg aacagcaaaa
     1561 ctccactcga gtccgtcaga acactaggga acatccctcc acggctaata cagtggatcg
     1621 aactaaccac cagctagaaa atctggaggc agaaactgct ccattgccct aactgggtct
     1681 cacaccatcc agaccctcgc taagcttaga ggccgccatc tacgtggaat caggttgctg
     1741 tcagggtgtg tgggaggctc tggtttcctg agaaaccatc tgatcctgca ttcaaagtca
     1801 ttcctctctg gctacttcac tctgcacatg agagatgctc agactgtatc aagtactcag
     1861 aaagaagaga ctaccggaca ctcctgaatc cagctcatgt acagaaccat ctgaaacacc
     1921 cagtggacca caatgctctg tggtatgtga atttcgatca tcatagaagg tgacccctct
     1981 ctatgtagaa tttttatttt tcaagcaaat acttatgacc tcatcaaaga aaataatgtc
     2041 acttgttaaa ttcactgtag tgatacataa agtaaatgct acctctgacc tctgacccag
     2101 tcaccttctg tagagagttc cagtcctttt gtgatggaat acatcatttc caacttaaaa
     2161 ctttcacctt gaagttatgg tctagttaag acatcagggg cacctccgtt tcttggtttt
     2221 gtattgtttg aaagaagacg acatcttcct ccttagctgt gtgttgaaaa tgaaagggat
     2281 tgaaagcaca gtgtcaactg cagaatggtt gattctcact ctgaaaggat ttacttcgag
     2341 ttataatgtg ggggttagga gaggggctgt tttttcctaa ttcccaccat gtcctctaag
     2401 tgttcacaag gtcaagttca gaaggtcacc cagtgagttc atcatgctat cattctgagc
     2461 aggaagccaa gaatttcgct ctcttcattt ttttcagtaa tttctccaca ctgcacgctc
     2521 ttttgtatta ttttccctga tgccttatga aacagcatga tcaaacaaca gatg
//
LOCUS       NM_053481               4509 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit beta (Pik3cb), mRNA.
ACCESSION   NM_053481
VERSION     NM_053481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Wang,J., Zhan,H., Wang,M., Song,H., Sun,J. and Zhao,G.
  TITLE     Sonic hedgehog signaling promotes angiogenesis of endothelial
            progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling
  JOURNAL   Aging (Albany NY) 15 (19), 10540-10548 (2023)
   PUBMED   37815888
  REMARK    GeneRIF: Sonic hedgehog signaling promotes angiogenesis of
            endothelial progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling.
            Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi:
            10.18632/aging.205458. PMID: 38157439]
REFERENCE   2  (bases 1 to 4509)
  AUTHORS   Mukhomedzyanov,A.V., Popov,S.V., Maslov,L.N., Diez,E.R. and
            Azev,V.N.
  TITLE     Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective
            Effect of Deltorphin II during Cardiac Reperfusion
  JOURNAL   Bull Exp Biol Med 175 (1), 17-19 (2023)
   PUBMED   37338759
  REMARK    GeneRIF: Role of PI3K, ERK1/2, and JAK2 Kinases in the
            Cardioprotective Effect of Deltorphin II during Cardiac
            Reperfusion.
REFERENCE   3  (bases 1 to 4509)
  AUTHORS   Cheng,Q., Wang,M., Jin,R. and Li,G.
  TITLE     Blocking of PI3-kinase beta protects against cerebral
            ischemia/reperfusion injury by reducing platelet activation and
            downstream microvascular thrombosis in rats
  JOURNAL   Sci Rep 13 (1), 2030 (2023)
   PUBMED   36739310
  REMARK    GeneRIF: Blocking of PI3-kinase beta protects against cerebral
            ischemia/reperfusion injury by reducing platelet activation and
            downstream microvascular thrombosis in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4509)
  AUTHORS   Zhang,L., Li,B., Li,W., Jiang,J., Chen,W., Yang,H. and Pan,D.
  TITLE     miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting
            PTEN and Activating the PI3K/AKT Signaling Pathway
  JOURNAL   Cells Tissues Organs 212 (6), 523-534 (2023)
   PUBMED   35717938
  REMARK    GeneRIF: miR-107 Attenuates Sepsis-Induced Myocardial Injury by
            Targeting PTEN and Activating the PI3K/AKT Signaling Pathway.
REFERENCE   5  (bases 1 to 4509)
  AUTHORS   Yang,B., Pan,C.S., Li,Q., Yang,Z., Long,F.X., Fan,J.Y., Wang,C.S.,
            Han,J.Y. and Tang,D.X.
  TITLE     Inhibitory effects of Chanling Gao on the proliferation and liver
            metastasis of transplanted colorectal cancer in nude mice
  JOURNAL   PLoS One 14 (2), e0201504 (2019)
   PUBMED   30789971
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4509)
  AUTHORS   Rajala,R.V., McClellan,M.E., Ash,J.D. and Anderson,R.E.
  TITLE     In vivo regulation of phosphoinositide 3-kinase in retina through
            light-induced tyrosine phosphorylation of the insulin receptor
            beta-subunit
  JOURNAL   J Biol Chem 277 (45), 43319-43326 (2002)
   PUBMED   12213821
  REMARK    GeneRIF: in vivo regulation in retina through light-induced
            tyrosine phosphorylation of the insulin receptor beta-subunit
REFERENCE   7  (bases 1 to 4509)
  AUTHORS   Alpini,G., Glaser,S., Alvaro,D., Ueno,Y., Marzioni,M., Francis,H.,
            Baiocchi,L., Stati,T., Barbaro,B., Phinizy,J.L., Mauldin,J. and
            Lesage,G.
  TITLE     Bile acid depletion and repletion regulate cholangiocyte growth and
            secretion by a phosphatidylinositol 3-kinase-dependent pathway in
            rats
  JOURNAL   Gastroenterology 123 (4), 1226-1237 (2002)
   PUBMED   12360484
  REMARK    GeneRIF: Bile acid depletion and repletion regulate cholangiocyte
            growth and secretion by a phosphatidylinositol 3-kinase-dependent
            pathway in rats.
REFERENCE   8  (bases 1 to 4509)
  AUTHORS   Crljen,V., Volinia,S. and Banfic,H.
  TITLE     Hepatocyte growth factor activates phosphoinositide 3-kinase C2
            beta in renal brush-border plasma membranes
  JOURNAL   Biochem J 365 (Pt 3), 791-799 (2002)
   PUBMED   11931646
  REMARK    GeneRIF: data show a spatial separation of the inositol lipid
            signalling system between brush border membranes (BBM) and
            basolateral membranes (BLM); hepatocyte growth factor causes
            activation of PLC and PI3K in BLM leading to activation of PI3K-C2
            beta in BBM
REFERENCE   9  (bases 1 to 4509)
  AUTHORS   Bi,L., Okabe,I., Bernard,D.J. and Nussbaum,R.L.
  TITLE     Early embryonic lethality in mice deficient in the p110beta
            catalytic subunit of PI 3-kinase
  JOURNAL   Mamm Genome 13 (3), 169-172 (2002)
   PUBMED   11919689
REFERENCE   10 (bases 1 to 4509)
  AUTHORS   Kim,Y.B., Ciaraldi,T.P., Kong,A., Kim,D., Chu,N., Mohideen,P.,
            Mudaliar,S., Henry,R.R. and Kahn,B.B.
  TITLE     Troglitazone but not metformin restores insulin-stimulated
            phosphoinositide 3-kinase activity and increases p110beta protein
            levels in skeletal muscle of type 2 diabetic subjects
  JOURNAL   Diabetes 51 (2), 443-448 (2002)
   PUBMED   11812753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ012482.1, CV117575.1, EV762942.1, EV765206.1, BQ202622.1 and
            AW523465.1.
            
            On Sep 30, 2014 this sequence version replaced NM_053481.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3213              AJ012482.1         1-3213
            3214-3539           CV117575.1         322-647
            3540-3799           EV762942.1         388-647
            3800-3801           EV765206.1         740-741             c
            3802-3833           EV762942.1         651-682
            3834-4043           EV765206.1         497-706             c
            4044-4232           BQ202622.1         277-465             c
            4233-4509           AW523465.1         1-277               c
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4509
                     /gene="Pik3cb"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit beta"
                     /db_xref="GeneID:85243"
                     /db_xref="RGD:620917"
     CDS             1..3213
                     /gene="Pik3cb"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.1.153"
                     /note="catalytic phosphatidylinositol 3-kinase beta; PI3K;
                     PI3Kbeta; ptdIns-3-kinase p110; PI3-kinase p110 subunit
                     beta; PI3K-beta; PI3-kinase subunit beta; ptdIns-3-kinase
                     subunit beta; ptdIns-3-kinase subunit p110-beta;
                     phosphatidylinositol 3-kinase, catalytic, beta
                     polypeptide; p110beta; phosphatidylinositol
                     4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;
                     phosphoinositide-3-kinase, catalytic, beta polypeptide;
                     serine/threonine protein kinase PIK3CB"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit beta isoform"
                     /protein_id="NP_445933.1"
                     /db_xref="GeneID:85243"
                     /db_xref="RGD:620917"
                     /translation="MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQL
                     EVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDV
                     RPFLPVLKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKI
                     QSLVGLSWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNL
                     NPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNR
                     TLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPLPLPPKKTRVISHVWGNNNPFQ
                     IVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINIC
                     DLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
                     QLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHIKFPENKKQPYYYPPF
                     DKIIEKAAEIASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCR
                     ENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV
                     GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEV
                     HTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKE
                     AMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCRYMDSKMKPLWLVYSNRAFGED
                     AVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVST
                     SETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYV
                     LGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGK
                     TGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLAL
                     GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS"
     misc_feature    121..354
                     /gene="Pik3cb"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; smart00143"
                     /db_xref="CDD:197539"
     misc_feature    121..354
                     /gene="Pik3cb"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; smart00143"
                     /db_xref="CDD:197539"
     misc_feature    538..864
                     /gene="Pik3cb"
                     /note="PI3-kinase family, Ras-binding domain; Region:
                     PI3K_rbd; smart00144"
                     /db_xref="CDD:197540"
     misc_feature    538..864
                     /gene="Pik3cb"
                     /note="PI3-kinase family, Ras-binding domain; Region:
                     PI3K_rbd; smart00144"
                     /db_xref="CDD:197540"
     misc_feature    970..1503
                     /gene="Pik3cb"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    970..1503
                     /gene="Pik3cb"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    970..972
                     /gene="Pik3cb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BTI9; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1L0.1); phosphorylation site"
     misc_feature    1228..1254
                     /gene="Pik3cb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1);
                     Region: Nuclear localization signal (NLS).
                     /evidence=ECO:0000250"
     misc_feature    1594..2106
                     /gene="Pik3cb"
                     /note="Phosphoinositide 3-kinase (PI3K) class I, accessory
                     domain; PIK domain is conserved in all PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. In general, PI3K
                     class I prefer phosphoinositol (4,5)...; Region: PI3Ka_I;
                     cd00872"
                     /db_xref="CDD:238444"
     misc_feature    1594..2106
                     /gene="Pik3cb"
                     /note="Phosphoinositide 3-kinase (PI3K) class I, accessory
                     domain; PIK domain is conserved in all PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. In general, PI3K
                     class I prefer phosphoinositol (4,5)...; Region: PI3Ka_I;
                     cd00872"
                     /db_xref="CDD:238444"
     misc_feature    2116..3201
                     /gene="Pik3cb"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase beta; Region: PI3Kc_IA_beta; cd05173"
                     /db_xref="CDD:270717"
     misc_feature    2116..3201
                     /gene="Pik3cb"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase beta; Region: PI3Kc_IA_beta; cd05173"
                     /db_xref="CDD:270717"
     misc_feature    2332..2352
                     /gene="Pik3cb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1);
                     Region: G-loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
     misc_feature    order(2335..2337,2341..2349,2353..2355,2407..2409,
                     2413..2415,2422..2424,2515..2517,2551..2562,2575..2577,
                     2584..2586,2770..2772,2776..2778,2806..2811)
                     /gene="Pik3cb"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270717"
     misc_feature    order(2335..2337,2341..2349,2353..2355,2407..2409,
                     2413..2415,2422..2424,2515..2517,2551..2562,2575..2577,
                     2584..2586,2770..2772,2776..2778,2806..2811)
                     /gene="Pik3cb"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270717"
     misc_feature    order(2536..2541,2620..2625,2632..2634,2842..2847,
                     2884..2886,2893..2895,2917..2928,2935..2937,3136..3138,
                     3145..3150,3154..3159)
                     /gene="Pik3cb"
                     /note="regulatory subunit interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:270717"
     misc_feature    order(2536..2541,2620..2625,2632..2634,2842..2847,
                     2884..2886,2893..2895,2917..2928,2935..2937,3136..3138,
                     3145..3150,3154..3159)
                     /gene="Pik3cb"
                     /note="regulatory subunit interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:270717"
     misc_feature    2677..2679
                     /gene="Pik3cb"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270717"
     misc_feature    2677..2679
                     /gene="Pik3cb"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270717"
     misc_feature    2746..2772
                     /gene="Pik3cb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1);
                     Region: Catalytic loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
     misc_feature    2746..2772
                     /gene="Pik3cb"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270717"
     misc_feature    2746..2772
                     /gene="Pik3cb"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270717"
     misc_feature    2803..2883
                     /gene="Pik3cb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1);
                     Region: Activation loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
     misc_feature    order(2809..2850,2866..2883)
                     /gene="Pik3cb"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270717"
     misc_feature    order(2809..2850,2866..2883)
                     /gene="Pik3cb"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270717"
     misc_feature    3208..3210
                     /gene="Pik3cb"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P42338; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1L0.1); phosphorylation site"
     exon            1..171
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            172..397
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            398..621
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            622..801
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            802..972
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1050
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1302
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1399
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1530
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1581
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1770
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1892
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2036
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2136
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2315
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2425
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2504
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2672
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2796
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2942
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3075
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..4494
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgcttcc gctctataat gcctcctgct atggcagaca cccttgacat ctgggccgtg
       61 gattcacaga tcgcgtctga tggctccatc tctgtcgatt tccttctgcc cactgggatt
      121 tatatccagt tggaagtacc ccgggaagct accatttctt atattaaaca gatgttatgg
      181 aagcaagttc acaattaccc aatgtttaac ctccttatgg acattgactc ctatatgttt
      241 gcctgtgtga atcaaactgc cgtatatgag gaacttgaag atgaaacacg aagactttgt
      301 gatgtcagac ctttccttcc agttctcaaa ctagtgacta gaagctgtga cccagcagaa
      361 aaattggact caaaaattgg agttcttata ggaaaaggtc ttcatgaatt tgatgccttg
      421 aaggatcctg aagtgaatga atttagaaga aaaatgcgca agttcagcga ggacaagatt
      481 cagtctctgg tggggctgtc ttggattgac tggctcaagc acacgtaccc gcccgagcac
      541 gaaccgtccg tcctggagaa cctggaagac aaactttatg gagggaagct ggttgtggct
      601 gtgcattttg aaaatagcca ggatgtattt agttttcaag tgtctcccaa tttgaatcct
      661 ataaaaataa atgaattggc aatccagaaa cgcctcacta ttcgcgggaa ggaagaggaa
      721 gctagcccct gtgactatgt gttacaggtc agtgggagag tggagtatgt gtttggtgac
      781 catccactga ttcagttcca gtatatccgg aattgtgtaa tgaacaggac cctgccccat
      841 ttcatccttg tggaatgttg taagatcaag aaaatgtatg aacaagaaat gattgccata
      901 gaggctgcca tcaaccgaaa ctcctccagc cttcctctcc ctttaccacc aaagaaaaca
      961 cgagttattt ctcatgtctg gggcaacaac aaccctttcc aaattgtctt ggtaaaagga
     1021 aataagctta acacagaaga aaccgtgaaa gttcatgtca gagccggact ttttcatgga
     1081 accgagctcc tgtgtaaaac cgtcgtaagc tcagagatat caggaaagaa tgaccatatt
     1141 tggaatgaac aactggaatt tgatattaat atttgtgact taccaagaat ggctcgatta
     1201 tgttttgctg tttacgcagt tttggataaa gtaaaaacga agaaatcaac aaaaactatt
     1261 aatccctcta aatatcagac catcaggaaa gcaggaaaag tgcattatcc tgttgcatgg
     1321 gtaaacacca tggtttttga cttcaaagga cagctgaggt ctggagacgt aatattgcac
     1381 agctggtctt cgtttcctga tgagctggaa gaaatgctga accccatggg gactgtgcag
     1441 acgaacccat atgctgagaa tgcaactgcc ttgcacatta agtttccgga gaacaagaag
     1501 cagccttatt attacccccc cttcgataag atcattgaga aggcagctga gattgccagt
     1561 ggagacagtg cgaacgtatc aagtcgtggt gggaaaaagt ttcttgctgt actgaaagaa
     1621 atcttggaca gggaccccct gtctcagctg tgtgagaacg aaatggacct tatttggact
     1681 ctacggcaag actgccgaga aaatttccca cagtcactgc caaaactact cctgtcaatc
     1741 aaatggaata aacttgaaga tgttgctcag cttcaggcgc tcctgcagat ttggcccaaa
     1801 ctgccaccca gggaagcact ggaactcctg gatttcaact atccagacca gtatgtccga
     1861 gagtacgctg taggctgcct gcgacagatg agtgatgaag aactctctca gtatctttta
     1921 cagttggtgc aagttttgaa gtacgagcct tttcttgact gtgccctctc cagattccta
     1981 ttggaaagag cacttgacaa ccggaggatt ggccagtttc tgttttggca tcttaggtca
     2041 gaggtgcaca ctcctgctgt gtccattcag tttggtgtca tcctagaggc atactgtcgg
     2101 ggaagcgtgg ggcacatgaa agtgctttcc aaacaggttg aagcactcaa taaattaaaa
     2161 actttaaata gcttaatcaa attgaatgcg atgaagctga acagagctaa aggaaaggag
     2221 gccatgcaca cgtgcttaaa acagagtgcc taccgggagg cgctctctga cctgcagtca
     2281 cctctgaacc catgtgtcat cctctcagag ctctatgtcg aaaagtgcag atacatggac
     2341 tccaagatga agccgctgtg gctggtctac agcaacaggg cctttggaga ggacgcggtg
     2401 ggagtgatct tcaaaaatgg cgacgatttg cggcaggaca tgctgaccct gcagatgctg
     2461 cgcctgatgg atctgctgtg gaaagaagct ggcttggacc tgcgaatgct cccctatggc
     2521 tgtctagcaa caggagatcg ctctggcctc attgaggttg tgagcacctc tgagacaatc
     2581 gctgacattc agctaaacag tagcaacgtg gctgccacag cagccttcaa caaagatgct
     2641 ctcctgaact ggctcaagga gtacaattct ggggacgacc tggacagagc gattgaggag
     2701 ttcaccctgt cctgtgctgg ctactgtgta gcctcttatg tccttggcat tggtgacagg
     2761 cacagtgaca acatcatggt gaagaaaacc ggccagctct tccacataga ctttgggcat
     2821 attcttggaa atttcaaatc taaatttggc attaaaaggg aacgagtacc ttttattctt
     2881 acttatgact tcattcatgt cattcaacaa ggaaaaacgg gaaacacaga aaaatttggc
     2941 aggttccgcc agtgctgtga agacgcgtac ctgattttac ggcggcatgg gaatctcttc
     3001 attaccctgt ttgcgctgat gttgactgca gggcttcccg agctcacatc agtcaaagat
     3061 atacagtatc ttaaggactc tcttgcctta ggaaagagtg aagaagaagc actcaaacag
     3121 tttaagcaga agtttgatga ggcactcagg gaaagctgga ccactaaggt gaactggatg
     3181 gctcatacag ttcggaaaga ctacaggtct tagcgtccgc tctgctctgc tgcacttgcc
     3241 tgtttgtctc ctttccattt tgcacttgca ctattgaaca tgaccctgcg ggaaatgcca
     3301 agggaatgaa atcctgaagc tcagcgtgaa gttcagaaca cggcatccca cagaagctcg
     3361 tctgaaccac cccaatgccc accctctgta actgagtgct tccaggactc atcatgagtg
     3421 tcagcagcag catggaggac cctttcctgc tgaccttgca cgccgaggaa tgctcctggg
     3481 gactgtttgg ggtctcttct ctcttttctt cagtgtttgg taccttccca gagaggcata
     3541 aatacttctt tccagtgttg accaagtgct gcaactcagc cagcaactta gcacatttgg
     3601 gggctggaaa ctgttctaag aaaggtatct ccctctcctt tttaaattgt gtgagctaca
     3661 aattacattg attatgttga acttattatt tttcaaagga aatattttaa acctgtgaaa
     3721 actcactaat tttgttaata tttatcatga tggcatcatt tcagccagac ttgctgagaa
     3781 tctattggtg ggcaaatata atatatataa tatatatata tatatatata tatgctgcat
     3841 atatatttat aaaatttcta gtgggagttc tatataaaga gatgtttctt tggtagtcct
     3901 cagccttgtt ttacagtttt acagaagcgg agctttttcc taagttactt ttcggttaac
     3961 tgtggatcca gtgcctccag tcgcctcact actgaggcac ctatgaatgt ggcttctctg
     4021 tgtagctctg agagttcatc tcagagaaca caatacttga gcagatgtat ccaaggaagc
     4081 aagcgaatga aaaggaatct atttatggaa taaactcgaa acctaaattt cagtatttta
     4141 gtaatatgcc agctgttctt aatgtattta ttaaaatgta taacattgtg atttttttca
     4201 acggtattag ttcaaatgga agtggatccg cgccacatgg aagtctgtaa cttacttgtt
     4261 gaggtaccac acagttcggg tgctaggcgg cgggtgtgag catgtgcaat agaactactg
     4321 gtttgctgtg tacatggacg tcaggatcca gcaaagctac tgcttcttct ccaaagacac
     4381 atgggagccc tcagtcctca gtggcacggg aaacacaact gagtacttgc cctgagactt
     4441 cagttttcta taggaatttt attaaagagt gtttaatttt gttgtccttc tgaaaaaaaa
     4501 aaaaaaaaa
//
LOCUS       NM_001304736            2318 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1H2, mRNA.
ACCESSION   NM_001304736
VERSION     NM_001304736.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2318)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2318)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2318)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2318)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2318)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1H2) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1H2) is shorter
            than isoform 1C2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU024651.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  45565371-45565459
            90-503              JAXUCZ010000001.1  45586060-45586473
            504-856             JAXUCZ010000001.1  45617450-45617802
            857-1377            JAXUCZ010000001.1  45618567-45619087
            1378-2318           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2318
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..89
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     CDS             70..1416
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1H2 is encoded by transcript variant
                     MOR-1H2; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1H2"
                     /protein_id="NP_001291665.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MGSGPMLAGPCKNLTEPRAAVRGRGWGAWNPKSLSALSYSLPSP
                     QQAFSTMDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGG
                     NDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNL
                     ALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIA
                     VCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW
                     YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLV
                     VVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDEN
                     FKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP"
     misc_feature    424..1260
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    424..1260
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    427..507
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    427..507
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    526..606
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    526..606
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    order(589..591,598..603,637..654,658..663,670..672,
                     805..807,811..825,904..906,913..921,925..933,937..942,
                     1096..1098,1105..1110,1114..1119,1126..1128,1159..1164,
                     1168..1176,1183..1185,1192..1197)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(589..591,598..603,637..654,658..663,670..672,
                     805..807,811..825,904..906,913..921,925..933,937..942,
                     1096..1098,1105..1110,1114..1119,1126..1128,1159..1164,
                     1168..1176,1183..1185,1192..1197)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    637..729
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    637..729
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    763..831
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    763..831
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    904..993
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    904..993
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1036..1128
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1036..1128
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1162..1239
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1162..1239
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     exon            90..503
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..856
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1377
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..2318
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctg gctggtccat gtaagaatct gacggagcct
      121 agggcagctg tgagaggaag aggctggggc gcgtggaacc cgaaaagtct gagtgctctc
      181 agttacagcc tacctagtcc gcagcaggcc ttcagcacca tggacagcag caccggccca
      241 gggaacacca gcgactgctc agacccctta gctcaggcaa gttgctcccc agcacctggc
      301 tcctggctca acttgtccca cgttgatggc aaccagtccg atccatgcgg tctgaaccgc
      361 accgggcttg gcgggaacga cagcctgtgc cctcagaccg gcagcccttc catggtcaca
      421 gccattacca tcatggccct ctactctatc gtgtgtgtag tgggcctctt cggaaacttc
      481 ctggtcatgt atgtgattgt aagatacacc aaaatgaaga ctgccaccaa catctacatt
      541 ttcaaccttg ctctggcaga cgccttagcg accagtacac tgccctttca gagtgtcaac
      601 tacctgatgg gaacatggcc cttcggaacc atcctctgca agatcgtgat ctcaatagat
      661 tactacaaca tgttcaccag catattcacc ctctgcacca tgagcgtgga ccgctacatt
      721 gctgtctgcc acccagtcaa agccctggat ttccgtaccc cccgaaatgc caaaatcgtc
      781 aacgtctgca actggatcct ctcttctgcc atcggtctgc ctgtaatgtt catggcaacc
      841 acaaaataca ggcaggggtc catagattgc accctcacgt tctcccaccc aacctggtac
      901 tgggagaacc tgctcaaaat ctgtgtcttt atcttcgctt tcatcatgcc ggtcctcatc
      961 atcactgtgt gttacggcct gatgatctta cgactcaaga gcgttcgcat gctatcgggc
     1021 tccaaagaaa aggacaggaa tctgcgcagg atcacccgga tggtgctggt ggtcgtggct
     1081 gtatttatcg tctgctggac ccccatccac atctacgtca tcatcaaagc gctgatcacg
     1141 attccagaaa ccacatttca gaccgtttcc tggcacttct gcattgcttt gggttacacg
     1201 aacagctgcc tgaatccagt tctttacgcc ttcctggatg aaaacttcaa gcgatgcttc
     1261 agagagttct gcatcccaac ctcgtccacg atcgaacagc aaaactccac tcgagtccgt
     1321 cagaacacta gggaacatcc ctccacggct aatacagtgg atcgaactaa ccaccagcta
     1381 gaaaatctgg aggcagaaac tgctccattg ccctaactgg gtctcacacc atccagaccc
     1441 tcgctaagct tagaggccgc catctacgtg gaatcaggtt gctgtcaggg tgtgtgggag
     1501 gctctggttt cctgagaaac catctgatcc tgcattcaaa gtcattcctc tctggctact
     1561 tcactctgca catgagagat gctcagactg tatcaagtac tcagaaagaa gagactaccg
     1621 gacactcctg aatccagctc atgtacagaa ccatctgaaa cacccagtgg accacaatgc
     1681 tctgtggtat gtgaatttcg atcatcatag aaggtgaccc ctctctatgt agaattttta
     1741 tttttcaagc aaatacttat gacctcatca aagaaaataa tgtcacttgt taaattcact
     1801 gtagtgatac ataaagtaaa tgctacctct gacctctgac ccagtcacct tctgtagaga
     1861 gttccagtcc ttttgtgatg gaatacatca tttccaactt aaaactttca ccttgaagtt
     1921 atggtctagt taagacatca ggggcacctc cgtttcttgg ttttgtattg tttgaaagaa
     1981 gacgacatct tcctccttag ctgtgtgttg aaaatgaaag ggattgaaag cacagtgtca
     2041 actgcagaat ggttgattct cactctgaaa ggatttactt cgagttataa tgtgggggtt
     2101 aggagagggg ctgttttttc ctaattccca ccatgtcctc taagtgttca caaggtcaag
     2161 ttcagaaggt cacccagtga gttcatcatg ctatcattct gagcaggaag ccaagaattt
     2221 cgctctcttc atttttttca gtaatttctc cacactgcac gctcttttgt attattttcc
     2281 ctgatgcctt atgaaacagc atgatcaaac aacagatg
//
LOCUS       NM_001270558            4845 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 3, mRNA.
ACCESSION   NM_001270558
VERSION     NM_001270558.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4845)
  AUTHORS   Chen,K., Xu,B., Qiu,S., Long,L., Zhao,Q., Xu,J. and Wang,H.
  TITLE     Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression
            and astrocyte swelling following cerebral ischemia/reperfusion
            injury
  JOURNAL   Glia 72 (9), 1629-1645 (2024)
   PUBMED   38785370
  REMARK    GeneRIF: Inhibition of phosphodiesterase 4 attenuates aquaporin 4
            expression and astrocyte swelling following cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 4845)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   3  (bases 1 to 4845)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   4  (bases 1 to 4845)
  AUTHORS   Pisani,F., Rossi,A., Nicchia,G.P., Svelto,M. and Frigeri,A.
  TITLE     Translational regulation mechanisms of aquaporin-4 supramolecular
            organization in astrocytes
  JOURNAL   Glia 59 (12), 1923-1932 (2011)
   PUBMED   21850708
  REMARK    GeneRIF: When transfected in Hela cells, the longer rat AQP4
            isoform, not present in humans, impairs formation of the orthogonal
            array of particles in astrocyte primary cultures.
REFERENCE   5  (bases 1 to 4845)
  AUTHORS   Hirt,B., Gleiser,C., Eckhard,A., Mack,A.F., Muller,M., Wolburg,H.
            and Lowenheim,H.
  TITLE     All functional aquaporin-4 isoforms are expressed in the rat
            cochlea and contribute to the formation of orthogonal arrays of
            particles
  JOURNAL   Neuroscience 189, 79-92 (2011)
   PUBMED   21621589
  REMARK    GeneRIF: Identified all functional AQP4 isoforms -M1, M23, and Mz-
            and the formation of higher-order complexes in the organ of Corti
            of the rat.
REFERENCE   6  (bases 1 to 4845)
  AUTHORS   Moe,S.E., Sorbo,J.G., Sogaard,R., Zeuthen,T., Petter Ottersen,O.
            and Holen,T.
  TITLE     New isoforms of rat Aquaporin-4
  JOURNAL   Genomics 91 (4), 367-377 (2008)
   PUBMED   18255256
  REMARK    GeneRIF: rat AQP4 has six cDNA isoforms, formed by alternative
            splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond
            to the two classical M1 and M23 isoforms, respectively
REFERENCE   7  (bases 1 to 4845)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 4845)
  AUTHORS   Jung,J.S., Bhat,R.V., Preston,G.M., Guggino,W.B., Baraban,J.M. and
            Agre,P.
  TITLE     Molecular characterization of an aquaporin cDNA from brain:
            candidate osmoreceptor and regulator of water balance
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13052-13056 (1994)
   PUBMED   7528931
REFERENCE   9  (bases 1 to 4845)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 4845)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            On Aug 28, 2014 this sequence version replaced NM_001270558.1.
            
            Summary: This gene encodes a member of the aquaporin family of
            intrinsic membrane proteins that function as water-selective
            channels in the plasma membranes of many cells. This protein is the
            predominant aquaporin found in brain and has an important role in
            brain water homeostasis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene. A
            recent study provided evidence for translational readthrough in
            this gene and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (3, also known as AQP4b) lacks an
            in-frame coding exon compared to variant 1. The resulting isoform
            (3) is shorter, missing an internal protein segment compared to
            isoform M1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.72622.1,
                                           SRR26360194.794453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 21850708
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000018.1  6798745-6798842     c
            99-513              JAXUCZ010000018.1  6794980-6795394     c
            514-594             JAXUCZ010000018.1  6792936-6793016     c
            595-4845            JAXUCZ010000018.1  6782389-6786639     c
FEATURES             Location/Qualifiers
     source          1..4845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..4845
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="aquaporin 4"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
     exon            1..98
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      38..70
                     /regulatory_class="uORF"
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21850708]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:21850708)"
     CDS             67..873
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     mercurial-insensitive water channel"
                     /codon_start=1
                     /product="aquaporin-4 isoform 3"
                     /protein_id="NP_001257487.1"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
                     /translation="MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLA
                     MLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTV
                     AMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTINYTGASMNPA
                     RSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQT
                     KGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV"
     misc_feature    133..135
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Region: alternative AUG translation initiation
                     site"
     misc_feature    157..645
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    157..645
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    order(295..297,349..357,526..531,538..540,547..549)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(295..297,349..357,526..531,538..540,547..549)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,538..546)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,538..546)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            99..513
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..594
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            595..4845
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctgattc ccgagcactg gagcctgggg gcaggcaatg agagctgcac tccggccagg
       61 gaaggcatga gtgacggagc tgcagcgagg cggtggggta agtgtggacc tccctgcagc
      121 agagagagca tcatggtggc tttcaaaggc gtctggactc aagccttctg gaaggcggtc
      181 acagcagagt tcctggccat gctcatcttt gttctgctca gcgtgggatc caccattaac
      241 tggggtggct cagagaaccc cctacctgtg gacatggtcc tcatctccct ctgctttgga
      301 ctcagcattg ccaccatggt tcagtgcttc ggccacatca gcggtggcca catcaaccca
      361 gcggtgacag tggccatggt gtgcacacga aagatcagca tcgccaagtc cgtcttctac
      421 atcactgcgc agtgcctggg ggccatcatc ggagctggga tcctctacct ggtcacaccc
      481 cccagcgtgg tgggaggatt gggagtcacc acgatcaatt ataccggagc cagcatgaat
      541 ccagctcgat cctttggccc tgcagttatc atgggaaact gggaaaacca ctggatatat
      601 tgggttggac caatcatagg cgctgtgctg gcaggtgcac tttacgagta tgtcttctgt
      661 cctgacgtgg agctcaaacg tcgcctaaag gaagccttca gcaaagctgc acagcagacg
      721 aaagggagct acatggaggt ggaggacaac cggagccaag tggagacaga agacttgatc
      781 ctgaagcccg gggtggtgca tgtgatcgac attgaccgtg gagacgagaa gaaggggaag
      841 gactcgtctg gagaggtatt atcttctgta tgactagagg acagcactga aaacagaaga
      901 gactccctag aactggcctc agatttcctg ccacccatta aggaaacaga tttgttataa
      961 attagacata tgcgggtttc ttgtttcaca tcttgttaca cagcttaaat aacacatatt
     1021 ttactattat caatgggggg gagaagccta taattaatat gacattttaa tggaaatctt
     1081 ttttaatgta tcctcgaagc aaatattcag ctactgtatt gactttcctt ttgttagtaa
     1141 taactgaaac tatgagccga aatctgatca agtcttactt aacagagcat tggacatctc
     1201 tgtgaggaag cttgtactgc ccatcctcac ttcaaaactg acaccattag attgatttaa
     1261 aaatgacaaa atgcagcaca tcaccgaatc atgtgcgttt taggagaaga aatgtagtaa
     1321 gttcttccac aagctatccc ttacttatta actaccttgg aggagttaaa aatagcactt
     1381 gccattgcta atatatcatg cgtatttata tagctgactg tcagatccca accccaattc
     1441 actataatcc ttcttccccc tcagcatcca agaaaccata gaactaaaag tcaaaagaaa
     1501 tggaaagaat attaacttct gtccatgtgt tggtttcatc taatgaaacc tgtacatggg
     1561 acacccaccc actgaggttc aggacagcca gacctgggga gtctggtggg aggtggagca
     1621 aaggttgcta cttacagtcc tacaaccatc acaagagggg caacctctgt tatgaaatga
     1681 ttgctctgtt ttcagtgcac actcttaagg ataccacaaa agattaactg cctaagcctt
     1741 taactacttc acttgctttt aaagcttatt tgcaaaattg gggaatttgt ttgccatttg
     1801 ggcacctata ctgaaacact agctgagata ttttagatga caacttgact agttgagtcc
     1861 tgcctttctg ttggtgtcta aatcctgctt actctaggtg gtataaacca gtcctgcccc
     1921 gtgccaactg ctaatgcttc ccatgacatc tgttgatggt cagcattgtg agtgtaataa
     1981 tacccattgg tgtggattaa aatatatggc agataaggtg caaggtagct gccaataaag
     2041 gtgtgagcag acagcctctg tgcaaagctc ctaggtgccc catcagcaca gagtgtacgt
     2101 gcttttaagg tatttacctc ctgcctgatt tatttgttag aaccatttgt ttttcccata
     2161 ctgctttgcc ttccgcccgt cgaatgctct gtggaaaccc cagtttctac actcatagca
     2221 gtctagccta acatttattt tagacaaagt gctgtaaacg tcaatttcac caaacaaaag
     2281 tcagtagtgg gagagagaag agccacctct tcaaggacta acttgtaaat agctgatcat
     2341 cagggctttc ttctcccaag cacaattcca gctgcgtgtg acttcttatt gttaatggca
     2401 gttttgtgtc tgtggcagca agataatgga ccactattaa agttgattct cttcggtgct
     2461 aggaaactga tatgcaagtt cccagacagc cacgaggaca gcatatgcct ctcagagcca
     2521 cgggcgtatt ctgaggtaga tgctgggagc ataggcctca tttcagggct ttgaatgtac
     2581 tacaccagag acataagctt cctctctgat cagaacctac agaaccaagg cgtagaccgg
     2641 tgttttcaca atataccaca tgggcttaag atcagggtgc tccagtcgga aggtgataac
     2701 cttcaacaaa catgttgggt taaaaccaaa ttaggggtcg ggtcaaaaat aaattcagtt
     2761 aaccaggaat agtggggcac atttctgatt actttttcaa aatcctggcc tgtgattatt
     2821 tttattatgc tacacagctt gcattgtgtg ctcactttct cagtcatttc cagggacagc
     2881 atccaatatg gtaggaactg aaaagcagtg aagtggagat gcattttcta gcagtggcag
     2941 agtgctgggc acacagtagg taatcacagc aagcatgctg tttgaatgtg tgtgtgtgtg
     3001 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacata tatatggctc tcatttggga
     3061 tttaagaaca ataacctctt ctaatttttg ctttgctcaa tctttagtgg aagcgtgatt
     3121 ttgagtgtta tcaaaggaag gtcatgtggg tgtggaaaca aagagcatgt tttcacattc
     3181 tactgtttaa gggcagagag tgacggcctc gtcactcttc gtcttgcatt tcactcacgg
     3241 ctctgccagt gaaacagtaa tgaaattgtc cctttctaat gacatctatg cagcaggggt
     3301 ctattgcctt gtgggtgaca ccaaattatc ctacatatta ggagatcagg gcttttcctt
     3361 taatcccttc ttattaagga gtgcatagtg ccgtacccaa gagacagcta ctggcagata
     3421 cagagcagag agatcagaga ggaaaaatca ggaaggcata aaagatttat acgagccatg
     3481 gaacaacgcc aactgtctgt tccctcagga ggagaacaga gtcacccccc aagtttcgag
     3541 gtggtccata cactggaaaa gtacacattc tgtcaaaaca cagcagaaag gaatcttttt
     3601 tttaagattt tgaggatttt ttttcaaatg taggactctg acttctaaat gtgtgtttcc
     3661 attttcttcc aaatgttcta ccctttcaca ctataagaaa atgttttctg tagcctaagt
     3721 cactggtaat tttacaactt gtttctgtgc tttgacacta ctcataaatt ctctcccttt
     3781 cgatcatcag agaagtgtcc ttccacatct cagagacact gctggccaga gctgctccct
     3841 gatgaagatt tcataaggag attagaaatc tctggaaagc atgcatgtta gaaatgagct
     3901 gatttcttag aggtcaattt caaaagcgca acacttctag gaggacccag gcaatgtgtg
     3961 cactgctcta accccactga tggcagtgaa atctcaaaac cggggaacta attaaaatga
     4021 tggcatgaga ccttgcctgg ccctttgttg tgtgacgttg acaccttcct cccacatcag
     4081 aaatctgaca gagacatgac ctctctgaca attgaagaca gagagccaaa tagacaatct
     4141 tataaaacta tgagaggttc ttatcattaa accacaggat atatgaatgt ggactcttgg
     4201 acctgaaagt cattacgtct ttctccagtg aactcatggg ataaaatctt aggaaagcat
     4261 ggtttctctt tgaaagtgta ctataacaac tcacttcctt tacgtcagct ttttgagctc
     4321 atgtctgggt gttactgctt ttcagaacac cttaaacaac acaaaccttt caaacccata
     4381 actctcagaa agaaatgtta ggcacttaac ttcaaaactc aaaaactgtg aatactcact
     4441 tttggcacat aacttccctg aaaacactca cccaacaaat gatacaacgc ataccatgaa
     4501 cactagattt aagagcagtt atagtgttac tgttttaagt caaaattcaa gagctaaaaa
     4561 atatacctaa catatatatt ccattgaaat gtattcctag actgttctca tgtttgatca
     4621 aataaacagc aatttatgga aatatgtaaa caattattta tcattttatc acccagatca
     4681 cgataaacct gcaacttatg aggaactaag aaaaataaaa tgaatgcctg gttatattta
     4741 caattattta ttaacttaat attattgcaa aattagagtt aatgttaaat ggatttaaac
     4801 tgtaatgact aatatttgga aaatctaata aaagtgttag ctgtg
//
LOCUS       NM_001038597            1467 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1A, mRNA.
ACCESSION   NM_001038597
VERSION     NM_001038597.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1467)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1467)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1467)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1467)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1467)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1467)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1467)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1467)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1 and AY309000.1.
            
            On Apr 20, 2007 this sequence version replaced NM_001038597.1.
            
            Transcript Variant: This variant (MOR-1A) lacks several exons and
            its 3' terminal exon extends past a splice site that is used in
            variant MOR-1C2. This results in a novel 3' coding region and 3'
            UTR, compared to variant MOR-1B2. It encodes isoform 1A which is
            longer/shorter and has a distinct C-terminus, compared to isoform
            1C2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY309000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               L13069.1           3-171
            170-1467            AY309000.1         1-1298
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1467
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1380
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform IA is encoded by transcript variant MOR-1A;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform IA"
                     /protein_id="NP_001033686.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQVCAF"
     misc_feature    232..234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    298..300
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    319..321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    343..345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    364..366
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    406..480
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    520..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    628..696
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    703..705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    757..822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..966
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1039..1119
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1144..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1201..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1288..1362
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1296
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1315..1317
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1330..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1467
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accaggtatg tgctttctag
     1381 aattacggat aacatataaa aataccatat ctggtaccag tctaagattt aaatctttaa
     1441 gaaggtcagt aacttgaggc aaagtcc
//
LOCUS       NM_001304740            2832 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1i3, mRNA.
ACCESSION   NM_001304740
VERSION     NM_001304740.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2832)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2832)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2832)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2832)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1i3) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1) is shorter
            than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU340246.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  45565371-45565459
            90-1017             JAXUCZ010000001.1  45585546-45586473
            1018-1370           JAXUCZ010000001.1  45617450-45617802
            1371-1891           JAXUCZ010000001.1  45618567-45619087
            1892-2832           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2832
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..89
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..1017
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    518..520
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     CDS             734..1930
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant MOR-1i3;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_001291669.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     misc_feature    758..760
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    824..826
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    845..847
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    869..871
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    890..892
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    932..1006
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    938..1774
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    938..1774
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    941..1021
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    941..1021
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    1040..1120
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    1040..1120
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    1046..1120
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(1103..1105,1112..1117,1151..1168,1172..1177,
                     1184..1186,1319..1321,1325..1339,1418..1420,1427..1435,
                     1439..1447,1451..1456,1610..1612,1619..1624,1628..1633,
                     1640..1642,1673..1678,1682..1690,1697..1699,1706..1711)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(1103..1105,1112..1117,1151..1168,1172..1177,
                     1184..1186,1319..1321,1325..1339,1418..1420,1427..1435,
                     1439..1447,1451..1456,1610..1612,1619..1624,1628..1633,
                     1640..1642,1673..1678,1682..1690,1697..1699,1706..1711)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    1151..1243
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    1151..1243
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    1154..1222
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1229..1231
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1277..1345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1277..1345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1283..1348
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1418..1507
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1418..1507
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1418..1492
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1550..1642
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1550..1642
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1565..1645
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1670..1741
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1676..1753
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1676..1753
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1727..1741
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1814..1888
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1820..1822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1841..1843
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1856..1858
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1913..1915
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            1018..1370
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1891
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2832
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgcta tacgcggacc agagtaaagg acaatactag
      121 tgggtctcca gccccattta attgcatatg ggcagttgag tcggaagagt gtttaagtat
      181 aagggtcatt gaccttataa cagatcaatg actttcctaa ctgatgaaaa caccgaccta
      241 atgtatggtt gttacaaaga aacttaactg ttctttttcc cacccttctc tgcaatgtct
      301 ctccttctgc gcccccttac cccactttac actcgtttac acggaagtgc atggagaccg
      361 accgaccgag gaggctgact ctctgattgc tttgcgcaaa atccactcct ctcctccctc
      421 ctctctagcc tctggatccc tcgcagcccg cgcgctccct cccttccacc cagagagtgg
      481 cgctttggga agctagagat gcgcctctgt gtacttctaa ggtgggaggg ggctacaagc
      541 agaggagaat atcagacgct cagacgttcc cttctgcctg ccgctcttct ctggttccac
      601 tagggctggt ccatgtaaga atctgacgga gcctagggca gctgtgagag gaagaggctg
      661 gggcgcgtgg aacccgaaaa gtctgagtgc tctcagttac agcctaccta gtccgcagca
      721 ggccttcagc accatggaca gcagcaccgg cccagggaac accagcgact gctcagaccc
      781 cttagctcag gcaagttgct ccccagcacc tggctcctgg ctcaacttgt cccacgttga
      841 tggcaaccag tccgatccat gcggtctgaa ccgcaccggg cttggcggga acgacagcct
      901 gtgccctcag accggcagcc cttccatggt cacagccatt accatcatgg ccctctactc
      961 tatcgtgtgt gtagtgggcc tcttcggaaa cttcctggtc atgtatgtga ttgtaagata
     1021 caccaaaatg aagactgcca ccaacatcta cattttcaac cttgctctgg cagacgcctt
     1081 agcgaccagt acactgccct ttcagagtgt caactacctg atgggaacat ggcccttcgg
     1141 aaccatcctc tgcaagatcg tgatctcaat agattactac aacatgttca ccagcatatt
     1201 caccctctgc accatgagcg tggaccgcta cattgctgtc tgccacccag tcaaagccct
     1261 ggatttccgt accccccgaa atgccaaaat cgtcaacgtc tgcaactgga tcctctcttc
     1321 tgccatcggt ctgcctgtaa tgttcatggc aaccacaaaa tacaggcagg ggtccataga
     1381 ttgcaccctc acgttctccc acccaacctg gtactgggag aacctgctca aaatctgtgt
     1441 ctttatcttc gctttcatca tgccggtcct catcatcact gtgtgttacg gcctgatgat
     1501 cttacgactc aagagcgttc gcatgctatc gggctccaaa gaaaaggaca ggaatctgcg
     1561 caggatcacc cggatggtgc tggtggtcgt ggctgtattt atcgtctgct ggacccccat
     1621 ccacatctac gtcatcatca aagcgctgat cacgattcca gaaaccacat ttcagaccgt
     1681 ttcctggcac ttctgcattg ctttgggtta cacgaacagc tgcctgaatc cagttcttta
     1741 cgccttcctg gatgaaaact tcaagcgatg cttcagagag ttctgcatcc caacctcgtc
     1801 cacgatcgaa cagcaaaact ccactcgagt ccgtcagaac actagggaac atccctccac
     1861 ggctaataca gtggatcgaa ctaaccacca gctagaaaat ctggaggcag aaactgctcc
     1921 attgccctaa ctgggtctca caccatccag accctcgcta agcttagagg ccgccatcta
     1981 cgtggaatca ggttgctgtc agggtgtgtg ggaggctctg gtttcctgag aaaccatctg
     2041 atcctgcatt caaagtcatt cctctctggc tacttcactc tgcacatgag agatgctcag
     2101 actgtatcaa gtactcagaa agaagagact accggacact cctgaatcca gctcatgtac
     2161 agaaccatct gaaacaccca gtggaccaca atgctctgtg gtatgtgaat ttcgatcatc
     2221 atagaaggtg acccctctct atgtagaatt tttatttttc aagcaaatac ttatgacctc
     2281 atcaaagaaa ataatgtcac ttgttaaatt cactgtagtg atacataaag taaatgctac
     2341 ctctgacctc tgacccagtc accttctgta gagagttcca gtccttttgt gatggaatac
     2401 atcatttcca acttaaaact ttcaccttga agttatggtc tagttaagac atcaggggca
     2461 cctccgtttc ttggttttgt attgtttgaa agaagacgac atcttcctcc ttagctgtgt
     2521 gttgaaaatg aaagggattg aaagcacagt gtcaactgca gaatggttga ttctcactct
     2581 gaaaggattt acttcgagtt ataatgtggg ggttaggaga ggggctgttt tttcctaatt
     2641 cccaccatgt cctctaagtg ttcacaaggt caagttcaga aggtcaccca gtgagttcat
     2701 catgctatca ttctgagcag gaagccaaga atttcgctct cttcattttt ttcagtaatt
     2761 tctccacact gcacgctctt ttgtattatt ttccctgatg ccttatgaaa cagcatgatc
     2821 aaacaacaga tg
//
LOCUS       NM_001304737            2646 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1i1, mRNA.
ACCESSION   NM_001304737
VERSION     NM_001304737.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1i1) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1) is shorter
            than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU340245.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000001.1  45565371-45565531
            162-831             JAXUCZ010000001.1  45585804-45586473
            832-1184            JAXUCZ010000001.1  45617450-45617802
            1185-1705           JAXUCZ010000001.1  45618567-45619087
            1706-2646           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2646
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..161
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..831
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    332..334
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     CDS             548..1744
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant MOR-1i1;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_001291666.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     misc_feature    572..574
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    638..640
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    659..661
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    683..685
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    704..706
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    746..820
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    752..1588
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    752..1588
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    755..835
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    755..835
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    854..934
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    854..934
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    860..934
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(917..919,926..931,965..982,986..991,998..1000,
                     1133..1135,1139..1153,1232..1234,1241..1249,1253..1261,
                     1265..1270,1424..1426,1433..1438,1442..1447,1454..1456,
                     1487..1492,1496..1504,1511..1513,1520..1525)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(917..919,926..931,965..982,986..991,998..1000,
                     1133..1135,1139..1153,1232..1234,1241..1249,1253..1261,
                     1265..1270,1424..1426,1433..1438,1442..1447,1454..1456,
                     1487..1492,1496..1504,1511..1513,1520..1525)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    965..1057
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    965..1057
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    968..1036
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1043..1045
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1091..1159
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1091..1159
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    1097..1162
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1232..1321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1232..1321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    1232..1306
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1364..1456
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1364..1456
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1379..1459
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1484..1555
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1490..1567
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1490..1567
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1541..1555
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1628..1702
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1634..1636
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1655..1657
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1670..1672
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1727..1729
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            832..1184
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..2646
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctg taagctttct ccaagtccgc attccaaaaa
      121 ctggacaggg agatagaaat caagagggga agttacctca gtgcatggag accgaccgac
      181 cgaggaggct gactctctga ttgctttgcg caaaatccac tcctctcctc cctcctctct
      241 agcctctgga tccctcgcag cccgcgcgct ccctcccttc cacccagaga gtggcgcttt
      301 gggaagctag agatgcgcct ctgtgtactt ctaaggtggg agggggctac aagcagagga
      361 gaatatcaga cgctcagacg ttcccttctg cctgccgctc ttctctggtt ccactagggc
      421 tggtccatgt aagaatctga cggagcctag ggcagctgtg agaggaagag gctggggcgc
      481 gtggaacccg aaaagtctga gtgctctcag ttacagccta cctagtccgc agcaggcctt
      541 cagcaccatg gacagcagca ccggcccagg gaacaccagc gactgctcag accccttagc
      601 tcaggcaagt tgctccccag cacctggctc ctggctcaac ttgtcccacg ttgatggcaa
      661 ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc gggaacgaca gcctgtgccc
      721 tcagaccggc agcccttcca tggtcacagc cattaccatc atggccctct actctatcgt
      781 gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat gtgattgtaa gatacaccaa
      841 aatgaagact gccaccaaca tctacatttt caaccttgct ctggcagacg ccttagcgac
      901 cagtacactg ccctttcaga gtgtcaacta cctgatggga acatggccct tcggaaccat
      961 cctctgcaag atcgtgatct caatagatta ctacaacatg ttcaccagca tattcaccct
     1021 ctgcaccatg agcgtggacc gctacattgc tgtctgccac ccagtcaaag ccctggattt
     1081 ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac tggatcctct cttctgccat
     1141 cggtctgcct gtaatgttca tggcaaccac aaaatacagg caggggtcca tagattgcac
     1201 cctcacgttc tcccacccaa cctggtactg ggagaacctg ctcaaaatct gtgtctttat
     1261 cttcgctttc atcatgccgg tcctcatcat cactgtgtgt tacggcctga tgatcttacg
     1321 actcaagagc gttcgcatgc tatcgggctc caaagaaaag gacaggaatc tgcgcaggat
     1381 cacccggatg gtgctggtgg tcgtggctgt atttatcgtc tgctggaccc ccatccacat
     1441 ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc acatttcaga ccgtttcctg
     1501 gcacttctgc attgctttgg gttacacgaa cagctgcctg aatccagttc tttacgcctt
     1561 cctggatgaa aacttcaagc gatgcttcag agagttctgc atcccaacct cgtccacgat
     1621 cgaacagcaa aactccactc gagtccgtca gaacactagg gaacatccct ccacggctaa
     1681 tacagtggat cgaactaacc accagctaga aaatctggag gcagaaactg ctccattgcc
     1741 ctaactgggt ctcacaccat ccagaccctc gctaagctta gaggccgcca tctacgtgga
     1801 atcaggttgc tgtcagggtg tgtgggaggc tctggtttcc tgagaaacca tctgatcctg
     1861 cattcaaagt cattcctctc tggctacttc actctgcaca tgagagatgc tcagactgta
     1921 tcaagtactc agaaagaaga gactaccgga cactcctgaa tccagctcat gtacagaacc
     1981 atctgaaaca cccagtggac cacaatgctc tgtggtatgt gaatttcgat catcatagaa
     2041 ggtgacccct ctctatgtag aatttttatt tttcaagcaa atacttatga cctcatcaaa
     2101 gaaaataatg tcacttgtta aattcactgt agtgatacat aaagtaaatg ctacctctga
     2161 cctctgaccc agtcaccttc tgtagagagt tccagtcctt ttgtgatgga atacatcatt
     2221 tccaacttaa aactttcacc ttgaagttat ggtctagtta agacatcagg ggcacctccg
     2281 tttcttggtt ttgtattgtt tgaaagaaga cgacatcttc ctccttagct gtgtgttgaa
     2341 aatgaaaggg attgaaagca cagtgtcaac tgcagaatgg ttgattctca ctctgaaagg
     2401 atttacttcg agttataatg tgggggttag gagaggggct gttttttcct aattcccacc
     2461 atgtcctcta agtgttcaca aggtcaagtt cagaaggtca cccagtgagt tcatcatgct
     2521 atcattctga gcaggaagcc aagaatttcg ctctcttcat ttttttcagt aatttctcca
     2581 cactgcacgc tcttttgtat tattttccct gatgccttat gaaacagcat gatcaaacaa
     2641 cagatg
//
LOCUS       NM_001038601            1649 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1C2, mRNA.
ACCESSION   NM_001038601
VERSION     NM_001038601.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1649)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1649)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1649)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1649)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1649)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1649)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1649)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1649)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1649)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1649)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1 and AY225403.1.
            
            On Apr 20, 2007 this sequence version replaced NM_001038601.1.
            
            Transcript Variant: This variant (MOR-1C2) encodes the longest
            isoform (1C2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY225403.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               L13069.1           3-171
            170-1649            AY225403.1         1-1480
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1649
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1614
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1C2 is encoded by transcript variant
                     MOR-1C2; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1C2"
                     /protein_id="NP_001033690.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQPALAVS
                     VAQIFTGYPSPTHGEKPCKSYRDRPRPCGRTWSLKSRAESNVEHFHCGAALIYNNELK
                     IGPVSWLQMPAHVLVRPW"
     misc_feature    232..234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    298..300
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    319..321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    343..345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    364..366
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    406..480
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    520..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    628..696
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    703..705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    757..822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..966
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1039..1119
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1144..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1201..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1288..1362
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1296
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1315..1317
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1330..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1454
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1548
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1649
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accagccagc cctggcagtc
     1381 agcgtggccc agatctttac aggatatcct tctccgactc atggtgaaaa accctgcaag
     1441 agttacaggg acagacctag accctgtgga agaacgtggt ctttgaaatc gcgtgcagaa
     1501 tccaatgtgg agcacttcca ttgtggagcc gcattaatct ataacaatga actaaaaata
     1561 gggccagtgt cctggctcca gatgcctgcg cacgtgctcg tgcgcccctg gtaatgaaca
     1621 cgggctccga ttctgaatat ccttctgtg
//
LOCUS       NM_001038600            1602 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1C1, mRNA.
ACCESSION   NM_001038600
VERSION     NM_001038600.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1 and AY225402.1.
            
            On Apr 20, 2007 this sequence version replaced NM_001038600.1.
            
            Transcript Variant: This variant (MOR-1C1) lacks an alternate
            segment in the 3' region, compared to variant MOR-1C2. It encodes
            isoform 1C1 which has is shorter than isoform 1C2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY225402.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               L13069.1           3-171
            170-1602            AY225402.1         1-1433
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1602
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1563
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1C1 is encoded by transcript variant
                     MOR-1C1; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1C1"
                     /protein_id="NP_001033689.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQPALAVS
                     VAQIFTGYPSPTHGEKPCKSYRDRPRPCGRTWSLKSRAESNVEHFHCGAALIYNNVNF
                     I"
     misc_feature    232..234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    298..300
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    319..321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    343..345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    364..366
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    406..480
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    520..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    628..696
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    703..705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    757..822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..966
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1039..1119
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1144..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1201..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1288..1362
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1296
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1315..1317
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1330..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1454
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1548
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1602
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accagccagc cctggcagtc
     1381 agcgtggccc agatctttac aggatatcct tctccgactc atggtgaaaa accctgcaag
     1441 agttacaggg acagacctag accctgtgga agaacgtggt ctttgaaatc gcgtgcagaa
     1501 tccaatgtgg agcacttcca ttgtggagcc gcattaatct ataacaatgt gaatttcatc
     1561 taaacacagg gatgtgctag tgagaagttt ggaggtgcag gc
//
LOCUS       NM_019204               2158 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus beta-secretase 1 (Bace1), mRNA.
ACCESSION   NM_019204
VERSION     NM_019204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Velazquez Toledano,J., Bello,M., Correa Basurto,J., Guerrero
            Gonzalez,I., Pacheco-Yepez,J. and Rosales Hernandez,M.C.
  TITLE     Determining Structural Changes for Ligand Recognition between Human
            and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by
            GSK3beta at Thr252 by in Vitro Studies
  JOURNAL   ACS Chem Neurosci 15 (3), 629-644 (2024)
   PUBMED   38227464
  REMARK    GeneRIF: Determining Structural Changes for Ligand Recognition
            between Human and Rat Phosphorylated BACE1 in Silico and Its
            Phosphorylation by GSK3beta at Thr252 by in Vitro Studies.
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Wang,X., Li,M. and Hu,Y.
  TITLE     miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in
            Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor
            Protein-Cleaving Enzyme 1
  JOURNAL   Physiol Res 72 (6), 833-841 (2023)
   PUBMED   38215068
  REMARK    GeneRIF: miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity
            in Alzheimer's Disease Through Regulating beta-Site Amyloid
            Precursor Protein-Cleaving Enzyme 1.
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Qu,J., Xiong,X., Hujie,G., Ren,J., Yan,L. and Ma,L.
  TITLE     MicroRNA-132-3p alleviates neuron apoptosis and impairments of
            learning and memory abilities in Alzheimer's disease by
            downregulation of HNRNPU stabilized BACE1
  JOURNAL   Cell Cycle 20 (21), 2309-2320 (2021)
   PUBMED   34585626
  REMARK    GeneRIF: MicroRNA-132-3p alleviates neuron apoptosis and
            impairments of learning and memory abilities in Alzheimer's disease
            by downregulation of HNRNPU stabilized BACE1.
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Babusikova,E., Dobrota,D., Turner,A.J. and Nalivaeva,N.N.
  TITLE     Effect of Global Brain Ischemia on Amyloid Precursor Protein
            Metabolism and Expression of Amyloid-Degrading Enzymes in Rat
            Cortex: Role in Pathogenesis of Alzheimer's Disease
  JOURNAL   Biochemistry (Mosc) 86 (6), 680-692 (2021)
   PUBMED   34225591
  REMARK    GeneRIF: Effect of Global Brain Ischemia on Amyloid Precursor
            Protein Metabolism and Expression of Amyloid-Degrading Enzymes in
            Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   De Pietri Tonelli,D., Mihailovich,M., Di Cesare,A., Codazzi,F.,
            Grohovaz,F. and Zacchetti,D.
  TITLE     Translational regulation of BACE-1 expression in neuronal and
            non-neuronal cells
  JOURNAL   Nucleic Acids Res 32 (5), 1808-1817 (2004)
   PUBMED   15034149
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Rogers,G.W. Jr., Edelman,G.M. and Mauro,V.P.
  TITLE     Differential utilization of upstream AUGs in the beta-secretase
            mRNA suggests that a shunting mechanism regulates translation
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 2794-2799 (2004)
   PUBMED   14981268
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Yan,R., Han,P., Miao,H., Greengard,P. and Xu,H.
  TITLE     The transmembrane domain of the Alzheimer's beta-secretase (BACE1)
            determines its late Golgi localization and access to beta -amyloid
            precursor protein (APP) substrate
  JOURNAL   J Biol Chem 276 (39), 36788-36796 (2001)
   PUBMED   11466313
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Lin,X., Koelsch,G., Wu,S., Downs,D., Dashti,A. and Tang,J.
  TITLE     Human aspartic protease memapsin 2 cleaves the beta-secretase site
            of beta-amyloid precursor protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1456-1460 (2000)
   PUBMED   10677483
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Vassar,R., Bennett,B.D., Babu-Khan,S., Kahn,S., Mendiaz,E.A.,
            Denis,P., Teplow,D.B., Ross,S., Amarante,P., Loeloff,R., Luo,Y.,
            Fisher,S., Fuller,J., Edenson,S., Lile,J., Jarosinski,M.A.,
            Biere,A.L., Curran,E., Burgess,T., Louis,J.C., Collins,F.,
            Treanor,J., Rogers,G. and Citron,M.
  TITLE     Beta-secretase cleavage of Alzheimer's amyloid precursor protein by
            the transmembrane aspartic protease BACE
  JOURNAL   Science 286 (5440), 735-741 (1999)
   PUBMED   10531052
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Urmoneit,B., Reinsch,C., Turner,J., Czech,C., Beyreuther,K. and
            Dyrks,T.
  TITLE     Inhibition of beta A4 production by specific modulation of
            beta-secretase activity
  JOURNAL   J Mol Neurosci 6 (1), 23-32 (1995)
   PUBMED   8562317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF190727.1 and JAXUCZ010000008.1.
            
            On Jan 31, 2014 this sequence version replaced NM_019204.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190727.1, SRR26643287.19966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 14981268
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1785              AF190727.1         1-1785
            1786-2158           JAXUCZ010000008.1  55060766-55061138
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2158
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="beta-secretase 1"
                     /db_xref="GeneID:29392"
                     /db_xref="RGD:2191"
     exon            1..688
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     regulatory      40..51
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:14981268]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:14981268)"
     regulatory      138..209
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:14981268]"
                     /note="this uORF is predicted to encode a 23 aa peptide
                     (PMID:14981268)"
     regulatory      204..209
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:14981268]"
                     /note="this uORF is predicted to encode 1 aa
                     (PMID:14981268)"
     regulatory      326..349
                     /regulatory_class="uORF"
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:14981268]"
                     /note="this uORF is predicted to encode a 7 aa peptide
                     (PMID:14981268)"
     misc_feature    347..349
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="upstream in-frame stop codon"
     CDS             428..1933
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /EC_number="3.4.23.46"
                     /note="ASP2; asp 2; memapsin-2; aspartyl protease 2;
                     membrane-associated aspartic protease 2; beta-site amyloid
                     precursor protein cleaving enzyme 1; beta-site APP
                     cleaving enzyme 1"
                     /codon_start=1
                     /product="beta-secretase 1 precursor"
                     /protein_id="NP_062077.1"
                     /db_xref="GeneID:29392"
                     /db_xref="RGD:2191"
                     /translation="MAPALRWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLP
                     RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG
                     AAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI
                     AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA
                     GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM
                     DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
                     TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGT
                     VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQT
                     DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK"
     sig_peptide     428..490
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     563..1930
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /product="Beta-secretase 1. /id=PRO_0000025944"
                     /note="propagated from UniProtKB/Swiss-Prot (P56819.1)"
     misc_feature    641..1738
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="Beta-secretase, aspartic-acid protease important in
                     the pathogenesis of Alzheimer's disease; Region:
                     beta_secretase_like; cd05473"
                     /db_xref="CDD:133140"
     misc_feature    641..1738
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="Beta-secretase, aspartic-acid protease important in
                     the pathogenesis of Alzheimer's disease; Region:
                     beta_secretase_like; cd05473"
                     /db_xref="CDD:133140"
     misc_feature    order(641..643,704..706,710..712,821..829,938..940,
                     992..994,1202..1204,1292..1294,1298..1306,1529..1531,
                     1571..1573)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="inhibitor binding site [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(641..643,704..706,710..712,821..829,938..940,
                     992..994,1202..1204,1292..1294,1298..1306,1529..1531,
                     1571..1573)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="inhibitor binding site [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(704..715,1292..1303)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(704..715,1292..1303)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(704..706,1292..1294)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(704..706,1292..1294)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:133140"
     misc_feature    803..805
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    order(812..823,833..844)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133140"
     misc_feature    order(812..823,833..844)
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133140"
     misc_feature    884..886
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); glycosylation site"
     misc_feature    941..943
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); glycosylation site"
     misc_feature    1094..1096
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); glycosylation site"
     misc_feature    1250..1252
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1262..1264
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1280..1282
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1322..1324
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1325..1327
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1346..1348
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P56817; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); acetylation site"
     misc_feature    1487..1489
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); glycosylation site"
     misc_feature    1799..1861
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="propagated from UniProtKB/Swiss-Prot (P56819.1);
                     transmembrane region"
     misc_feature    1862..1930
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="propagated from UniProtKB/Swiss-Prot (P56819.1);
                     Region: Interaction with RTN3. /evidence=ECO:0000250"
     misc_feature    1913..1927
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="propagated from UniProtKB/Swiss-Prot (P56819.1);
                     Region: DXXLL. /evidence=ECO:0000250|UniProtKB:P56817"
     misc_feature    1919..1921
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56818; propagated from
                     UniProtKB/Swiss-Prot (P56819.1); phosphorylation site"
     exon            689..777
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            778..994
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1132
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1267
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1369
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1519
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1691
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2158
                     /gene="Bace1"
                     /gene_synonym="Bace"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccagcctg cctaggtgct gggagccggg agctggatta tggtggcctg agcagccgac
       61 gcagccgcag gagctgggag tccctcacgc tgcaaagtcc gcctggaaga ccctgaaagc
      121 tgcaggctcc gatagccatg cccgcccctc ccagccccac aaggggcccg atccccccgc
      181 tgaggctggc ggtcgccgtc cagatgtagc tgggtccccc ggatcgccat cgtcctcttc
      241 tctcgtgcgc tacagatttc tcctgcccac tctccaccgc cgggagcagg aactgagcga
      301 ggggcctgca gactctgcag tcctgatgcc cccgaggccg ctctcctgag agaagccacc
      361 accacccaga cttaggggca ggcaagaggg acagtcgcca accggagcca caaggcccgg
      421 gctcaccatg gccccggcgc tgcgctggct cctgctatgg gtgggctcgg gaatgctgcc
      481 tgcccaggga acccatctcg gtatccgact gccccttcgc agcggcctgg cagggccacc
      541 cctgggcctg aggctgcccc gggagacgga cgaggaacct gaggagcctg gccggagagg
      601 cagctttgtg gagatggtgg acaacctgag gggaaagtcc ggccagggct actatgtgga
      661 gatgaccgtg ggcagccccc cacagacgct caacatcctg gtggacacgg gcagtagtaa
      721 ttttgcagtg ggggctgccc cacacccttt cctgcatcga tactaccaaa ggcagctgtc
      781 cagtacatac cgagacctcc gaaagtctgt gtatgtgccc tacacccagg gcaagtggga
      841 gggggaactg ggcactgacc tggtgagcat ccctcatggc cccaacgtca ctgtgcgtgc
      901 caacattgct gccatcactg aatcggacaa gttcttcatc aatggttcca actgggaggg
      961 catcctaggg ctggcctatg ctgagattgc caggcctgac gactccttgg agcccttttt
     1021 tgactccctg gtgaagcaga cccacattcc gaacatcttt tccctgcagc tctgtggcgc
     1081 tggcttcccc ctcaaccaga ctgaggcact ggcctcggtg ggagggagca tgatcattgg
     1141 tggtatcgac cattccctat acactggcag tctctggtac acacccatcc ggcgggagtg
     1201 gtattatgaa gtgatcattg tacgtgtaga aatcaatggt caagatctga aaatggactg
     1261 caaggagtac aactatgaca agagcatcgt ggacagtggc accaccaacc ttcgtttgcc
     1321 caagaaagta tttgaagctg cagtcaagtc catcaaggca gcctcctcga cggagaagtt
     1381 cccggatggc ttttggctag gggagcagct ggtgtgctgg caagcaggca cgaccccttg
     1441 gaacattttc ccagtcattt cactttacct catgggtgaa gtcaccaatc agtccttccg
     1501 catcaccatc cttcctcagc aatacctacg gccagtggaa gatgtggcca cgtcccaaga
     1561 cgactgttac aagttcgccg tctcacagtc atccacaggc accgttatgg gagcggtcat
     1621 catggaaggc ttctatgtgg tctttgatcg agcccgaaag cgaattggct ttgctgtcag
     1681 cgcttgccat gtgcacgatg agttcaggac ggcggcagtg gaaggtccgt ttgtcacggc
     1741 agacatggaa gactgtggct acaacattcc acagacagat gagtcgacac ttatgaccat
     1801 agcctatgtc atggctgcca tctgcgccct cttcatgttg ccactctgcc tcatggtatg
     1861 tcagtggcgc tgcctacgct gcctgcgcca tcagcatgat gactttgctg atgacatctc
     1921 cctgctgaaa taaggaggcc agtgggcaga tgacagagat ccccctggac cacatctggg
     1981 tggttccctt tggtcacgtg agttggagat atggatggta cctgtggcca gagcacctca
     2041 ggaccctcac caacctgccg aatgcttctg ccttgacaga aaagagacag ctggcaagct
     2101 ggattacagg gcttgcaagg cctgtaggaa acaggaggga gaaagcagca ttctggtg
//
LOCUS       NM_031701               1442 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus claudin 5 (Cldn5), mRNA.
ACCESSION   NM_031701 XM_344058
VERSION     NM_031701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Hirose,Y., Oda,Y., Yoshino,K., Yano,F., Kimura,M., Kimura,H.,
            Iyo,M. and Shirayama,Y.
  TITLE     Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1
            and CA-3 regions of a learned helplessness model of depression
  JOURNAL   Pharmacol Biochem Behav 234, 173676 (2024)
   PUBMED   37992974
  REMARK    GeneRIF: Reduction of claudin-5 and aquaporin-4 in the rat
            hippocampal CA-1 and CA-3 regions of a learned helplessness model
            of depression.
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Hu,Q., Wu,C., Yu,J., Luo,J. and Peng,X.
  TITLE     Angelica sinensis polysaccharide improves rheumatoid arthritis by
            modifying the expression of intestinal Cldn5, Slit3 and Rgs18
            through gut microbiota
  JOURNAL   Int J Biol Macromol 209 (Pt A), 153-161 (2022)
   PUBMED   35318077
  REMARK    GeneRIF: Angelica sinensis polysaccharide improves rheumatoid
            arthritis by modifying the expression of intestinal Cldn5, Slit3
            and Rgs18 through gut microbiota.
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Andersson,E.A., Rocha-Ferreira,E., Hagberg,H., Mallard,C. and
            Ek,C.J.
  TITLE     Function and Biomarkers of the Blood-Brain Barrier in a Neonatal
            Germinal Matrix Haemorrhage Model
  JOURNAL   Cells 10 (7), 1677 (2021)
   PUBMED   34359845
  REMARK    GeneRIF: Function and Biomarkers of the Blood-Brain Barrier in a
            Neonatal Germinal Matrix Haemorrhage Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Rosas-Martinez,L., Rodriguez-Munoz,R., Namorado-Tonix,M.D.C.,
            Missirlis,F., Del Valle-Mondragon,L., Sanchez-Mendoza,A.,
            Reyes-Sanchez,J.L. and Cervantes-Perez,L.G.
  TITLE     Hyperglycemic levels in early stage of diabetic nephropathy affect
            differentially renal expression of claudins-2 and -5 by oxidative
            stress
  JOURNAL   Life Sci 268, 119003 (2021)
   PUBMED   33417957
  REMARK    GeneRIF: Hyperglycemic levels in early stage of diabetic
            nephropathy affect differentially renal expression of claudins-2
            and -5 by oxidative stress.
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Shou,J., Peng,J., Zhao,Z., Huang,X., Li,H., Li,L., Gao,X., Xing,Y.
            and Liu,H.
  TITLE     CCL26 and CCR3 are associated with the acute inflammatory response
            in the CNS in experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 333, 576967 (2019)
   PUBMED   31151084
  REMARK    GeneRIF: The expression of claudin-5 in the EAE group was
            negatively correlated with the inflammation scores. Levels of CCL26
            in the serum and brain tissues and the number of CCR3-positive
            cells in the brain tissues were negatively correlated with the
            protein expression of claudin-5.
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Sun,Z.Y., Wei,J., Xie,L., Shen,Y., Liu,S.Z., Ju,G.Z., Shi,J.P.,
            Yu,Y.Q., Zhang,X., Xu,Q. and Hemmings,G.P.
  TITLE     The CLDN5 locus may be involved in the vulnerability to
            schizophrenia
  JOURNAL   Eur Psychiatry 19 (6), 354-357 (2004)
   PUBMED   15363474
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Wolburg,H., Wolburg-Buchholz,K., Kraus,J., Rascher-Eggstein,G.,
            Liebner,S., Hamm,S., Duffner,F., Grote,E.H., Risau,W. and
            Engelhardt,B.
  TITLE     Localization of claudin-3 in tight junctions of the blood-brain
            barrier is selectively lost during experimental autoimmune
            encephalomyelitis and human glioblastoma multiforme
  JOURNAL   Acta Neuropathol 105 (6), 586-592 (2003)
   PUBMED   12734665
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Nitta,T., Hata,M., Gotoh,S., Seo,Y., Sasaki,H., Hashimoto,N.,
            Furuse,M. and Tsukita,S.
  TITLE     Size-selective loosening of the blood-brain barrier in
            claudin-5-deficient mice
  JOURNAL   J Cell Biol 161 (3), 653-660 (2003)
   PUBMED   12743111
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Poliak,S., Matlis,S., Ullmer,C., Scherer,S.S. and Peles,E.
  TITLE     Distinct claudins and associated PDZ proteins form different
            autotypic tight junctions in myelinating Schwann cells
  JOURNAL   J Cell Biol 159 (2), 361-372 (2002)
   PUBMED   12403818
  REMARK    GeneRIF: MUPP1 and claudin-5 colocalized in the incisures, and the
            COOH-terminal region of claudin-5 interacts with MUPP1 in a
            PSD-95/Disc Large/zona occludens (ZO)-1 (PDZ)-dependent manner in
            tight junctions
REFERENCE   10 (bases 1 to 1442)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK479973.1, BC082073.1 and AI029697.1.
            
            On Nov 18, 2005 this sequence version replaced NM_031701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: FQ212855.1, FQ213419.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CK479973.1         1-11
            12-1424             BC082073.1         10-1422
            1425-1442           AI029697.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1442
                     /gene="Cldn5"
                     /note="claudin 5"
                     /db_xref="GeneID:65131"
                     /db_xref="RGD:68431"
     exon            1..1427
                     /gene="Cldn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..799
                     /gene="Cldn5"
                     /codon_start=1
                     /product="claudin-5"
                     /protein_id="NP_113889.1"
                     /db_xref="GeneID:65131"
                     /db_xref="RGD:68431"
                     /translation="MGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQ
                     TTWKGLWMSCVVQSTGHMQCKVYESVLALSAEVQAARALTVGAVLLALVALFVTLTGA
                     QCTTCVAPGPVKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPVSQKYEL
                     GAALYIGWAASALLMCGGGLVCCGAWVCTGRPEFSFPVKYSAPRRTTANGDYDKKNYV
                     "
     misc_feature    155..682
                     /gene="Cldn5"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    155..682
                     /gene="Cldn5"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    164..226
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    386..448
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    512..574
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    623..685
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     transmembrane region"
     misc_feature    791..796
                     /gene="Cldn5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD6.2);
                     Region: Interactions with TJP1, TJP2 and TJP3.
                     /evidence=ECO:0000250"
ORIGIN      
        1 tgtggttgaa acctctcttc tgttccactg caagaggctc cggagcagag gcaccagaat
       61 cagcccccaa cccacagccc acgcagcgca gagcgcaccc ggaggcccca agggccatcg
      121 ggtgagcatt cggtctttag ccatggggtc tgcagcgttg gaaattctgg gtctggtgct
      181 gtgtctggta ggctgggtgg gcttgatcct ggcgtgtggg ctgcccatgt ggcaggtgac
      241 tgccttcctg gaccacaata tcgtgacggc gcagacgact tggaaggggc tgtggatgtc
      301 gtgcgtggtg cagagcaccg ggcacatgca atgcaaagtg tatgagtctg tgctggcgct
      361 gagcgcggag gtgcaggcag ctcgggcact caccgtgggc gctgtgctgc tggcgcttgt
      421 ggcactcttt gttaccttga ccggcgctca gtgcaccacc tgcgtggccc cgggcccagt
      481 taaggcacgg gtggcactca cgggaggagc gctttatgcc ctgtgtgggc ttctggcact
      541 ggtgccactc tgctggttcg ccaacatcgt agtccgggag ttctatgatc caacggtgcc
      601 ggtgtctcag aagtacgagc tgggcgcggc gctgtacatc ggctgggcgg cctccgcact
      661 gctcatgtgt ggcggcggcc tcgtgtgctg tggcgcctgg gtttgcaccg ggcgtccaga
      721 gttcagtttt ccagtcaagt actcagcacc aaggcgaacc acggccaacg gcgattacga
      781 caagaagaac tacgtctaag ggcgggaggc acggcggggc tcttcccgca gctaagcccg
      841 cgttcggaaa gaccgatgtg ggaagccgcg tgtggatgac gaccaccgct gaattgcgca
      901 gcgcagactc cgaggcaagt taggttgggt tcgggccaga cttgcgcgct ctcacagaga
      961 ggggtcgttg atcaacgcta gccaggccct gctcagaaca gactacaggc tcttgtgagg
     1021 acttgaccga ccttttcttc tatgcgcagt tggccacgac atggtggaac tctaagattt
     1081 catcggtgaa gtagccacca aactgccgct aacagttcct actgagtcct ggggagtgct
     1141 ggatgctgcc ttaatgtccg gtggtacctg ctaacctgaa agggcagctg gggaaaccct
     1201 ggggctgcca gaggaatgcg ttaaaaaggg catttttctt gttagtggag aggaacctac
     1261 tgaaccaaag gacttgccct ggacctggtc tcattccagc agtcccccaa ggtgaggggg
     1321 cctgtaggta ccagagcctt agaagggttg ccttcctcct cgaagcttgg ggtttggggg
     1381 gtgggccggg taagactttg cttagtaaat ggtttgaaca ctttcaaaaa aaaaaaaaaa
     1441 aa
//
LOCUS       NM_001270559            4853 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 4, mRNA.
ACCESSION   NM_001270559
VERSION     NM_001270559.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Chen,K., Xu,B., Qiu,S., Long,L., Zhao,Q., Xu,J. and Wang,H.
  TITLE     Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression
            and astrocyte swelling following cerebral ischemia/reperfusion
            injury
  JOURNAL   Glia 72 (9), 1629-1645 (2024)
   PUBMED   38785370
  REMARK    GeneRIF: Inhibition of phosphodiesterase 4 attenuates aquaporin 4
            expression and astrocyte swelling following cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Pisani,F., Rossi,A., Nicchia,G.P., Svelto,M. and Frigeri,A.
  TITLE     Translational regulation mechanisms of aquaporin-4 supramolecular
            organization in astrocytes
  JOURNAL   Glia 59 (12), 1923-1932 (2011)
   PUBMED   21850708
  REMARK    GeneRIF: When transfected in Hela cells, the longer rat AQP4
            isoform, not present in humans, impairs formation of the orthogonal
            array of particles in astrocyte primary cultures.
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Hirt,B., Gleiser,C., Eckhard,A., Mack,A.F., Muller,M., Wolburg,H.
            and Lowenheim,H.
  TITLE     All functional aquaporin-4 isoforms are expressed in the rat
            cochlea and contribute to the formation of orthogonal arrays of
            particles
  JOURNAL   Neuroscience 189, 79-92 (2011)
   PUBMED   21621589
  REMARK    GeneRIF: Identified all functional AQP4 isoforms -M1, M23, and Mz-
            and the formation of higher-order complexes in the organ of Corti
            of the rat.
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   Moe,S.E., Sorbo,J.G., Sogaard,R., Zeuthen,T., Petter Ottersen,O.
            and Holen,T.
  TITLE     New isoforms of rat Aquaporin-4
  JOURNAL   Genomics 91 (4), 367-377 (2008)
   PUBMED   18255256
  REMARK    GeneRIF: rat AQP4 has six cDNA isoforms, formed by alternative
            splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond
            to the two classical M1 and M23 isoforms, respectively
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Jung,J.S., Bhat,R.V., Preston,G.M., Guggino,W.B., Baraban,J.M. and
            Agre,P.
  TITLE     Molecular characterization of an aquaporin cDNA from brain:
            candidate osmoreceptor and regulator of water balance
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13052-13056 (1994)
   PUBMED   7528931
REFERENCE   9  (bases 1 to 4853)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            On Aug 28, 2014 this sequence version replaced NM_001270559.1.
            
            Summary: This gene encodes a member of the aquaporin family of
            intrinsic membrane proteins that function as water-selective
            channels in the plasma membranes of many cells. This protein is the
            predominant aquaporin found in brain and has an important role in
            brain water homeostasis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene. A
            recent study provided evidence for translational readthrough in
            this gene and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (4, also known as AQP4d) contains
            an alternate 5' terminal exon and lacks an in-frame coding exon
            compared to variant 1. These changes result in translation
            initiation from an in-frame, downstream start codon, and an isoform
            (4) with a shorter N-terminus and missing an internal protein
            segment compared to isoform M1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1357710.1,
                                           SRR26360176.146936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000018.1  6797821-6797926     c
            107-521             JAXUCZ010000018.1  6794980-6795394     c
            522-602             JAXUCZ010000018.1  6792936-6793016     c
            603-4853            JAXUCZ010000018.1  6782389-6786639     c
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..4853
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="aquaporin 4"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
     exon            1..106
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            107..521
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..881
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="isoform 4 is encoded by transcript variant 4;
                     mercurial-insensitive water channel"
                     /codon_start=1
                     /product="aquaporin-4 isoform 4"
                     /protein_id="NP_001257488.1"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
                     /translation="MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPL
                     PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCL
                     GAIIGAGILYLVTPPSVVGGLGVTTINYTGASMNPARSFGPAVIMGNWENHWIYWVGP
                     IIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILK
                     PGVVHVIDIDRGDEKKGKDSSGEVLSSV"
     misc_feature    165..653
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    165..653
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    order(303..305,357..365,534..539,546..548,555..557)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(303..305,357..365,534..539,546..548,555..557)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(363..371,546..554)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(363..371,546..554)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            522..602
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..4853
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct cggtcccctc ctcttttttt cctatcaaac cccagaagac agcacctgtg
       61 atagcacctt gcccctctgc cacctggcta caaccctgga cagctgtaag tgtggacctc
      121 cctgcagcag agagagcatc atggtggctt tcaaaggcgt ctggactcaa gccttctgga
      181 aggcggtcac agcagagttc ctggccatgc tcatctttgt tctgctcagc gtgggatcca
      241 ccattaactg gggtggctca gagaaccccc tacctgtgga catggtcctc atctccctct
      301 gctttggact cagcattgcc accatggttc agtgcttcgg ccacatcagc ggtggccaca
      361 tcaacccagc ggtgacagtg gccatggtgt gcacacgaaa gatcagcatc gccaagtccg
      421 tcttctacat cactgcgcag tgcctggggg ccatcatcgg agctgggatc ctctacctgg
      481 tcacaccccc cagcgtggtg ggaggattgg gagtcaccac gatcaattat accggagcca
      541 gcatgaatcc agctcgatcc tttggccctg cagttatcat gggaaactgg gaaaaccact
      601 ggatatattg ggttggacca atcataggcg ctgtgctggc aggtgcactt tacgagtatg
      661 tcttctgtcc tgacgtggag ctcaaacgtc gcctaaagga agccttcagc aaagctgcac
      721 agcagacgaa agggagctac atggaggtgg aggacaaccg gagccaagtg gagacagaag
      781 acttgatcct gaagcccggg gtggtgcatg tgatcgacat tgaccgtgga gacgagaaga
      841 aggggaagga ctcgtctgga gaggtattat cttctgtatg actagaggac agcactgaaa
      901 acagaagaga ctccctagaa ctggcctcag atttcctgcc acccattaag gaaacagatt
      961 tgttataaat tagacatatg cgggtttctt gtttcacatc ttgttacaca gcttaaataa
     1021 cacatatttt actattatca atggggggga gaagcctata attaatatga cattttaatg
     1081 gaaatctttt ttaatgtatc ctcgaagcaa atattcagct actgtattga ctttcctttt
     1141 gttagtaata actgaaacta tgagccgaaa tctgatcaag tcttacttaa cagagcattg
     1201 gacatctctg tgaggaagct tgtactgccc atcctcactt caaaactgac accattagat
     1261 tgatttaaaa atgacaaaat gcagcacatc accgaatcat gtgcgtttta ggagaagaaa
     1321 tgtagtaagt tcttccacaa gctatccctt acttattaac taccttggag gagttaaaaa
     1381 tagcacttgc cattgctaat atatcatgcg tatttatata gctgactgtc agatcccaac
     1441 cccaattcac tataatcctt cttccccctc agcatccaag aaaccataga actaaaagtc
     1501 aaaagaaatg gaaagaatat taacttctgt ccatgtgttg gtttcatcta atgaaacctg
     1561 tacatgggac acccacccac tgaggttcag gacagccaga cctggggagt ctggtgggag
     1621 gtggagcaaa ggttgctact tacagtccta caaccatcac aagaggggca acctctgtta
     1681 tgaaatgatt gctctgtttt cagtgcacac tcttaaggat accacaaaag attaactgcc
     1741 taagccttta actacttcac ttgcttttaa agcttatttg caaaattggg gaatttgttt
     1801 gccatttggg cacctatact gaaacactag ctgagatatt ttagatgaca acttgactag
     1861 ttgagtcctg cctttctgtt ggtgtctaaa tcctgcttac tctaggtggt ataaaccagt
     1921 cctgccccgt gccaactgct aatgcttccc atgacatctg ttgatggtca gcattgtgag
     1981 tgtaataata cccattggtg tggattaaaa tatatggcag ataaggtgca aggtagctgc
     2041 caataaaggt gtgagcagac agcctctgtg caaagctcct aggtgcccca tcagcacaga
     2101 gtgtacgtgc ttttaaggta tttacctcct gcctgattta tttgttagaa ccatttgttt
     2161 ttcccatact gctttgcctt ccgcccgtcg aatgctctgt ggaaacccca gtttctacac
     2221 tcatagcagt ctagcctaac atttatttta gacaaagtgc tgtaaacgtc aatttcacca
     2281 aacaaaagtc agtagtggga gagagaagag ccacctcttc aaggactaac ttgtaaatag
     2341 ctgatcatca gggctttctt ctcccaagca caattccagc tgcgtgtgac ttcttattgt
     2401 taatggcagt tttgtgtctg tggcagcaag ataatggacc actattaaag ttgattctct
     2461 tcggtgctag gaaactgata tgcaagttcc cagacagcca cgaggacagc atatgcctct
     2521 cagagccacg ggcgtattct gaggtagatg ctgggagcat aggcctcatt tcagggcttt
     2581 gaatgtacta caccagagac ataagcttcc tctctgatca gaacctacag aaccaaggcg
     2641 tagaccggtg ttttcacaat ataccacatg ggcttaagat cagggtgctc cagtcggaag
     2701 gtgataacct tcaacaaaca tgttgggtta aaaccaaatt aggggtcggg tcaaaaataa
     2761 attcagttaa ccaggaatag tggggcacat ttctgattac tttttcaaaa tcctggcctg
     2821 tgattatttt tattatgcta cacagcttgc attgtgtgct cactttctca gtcatttcca
     2881 gggacagcat ccaatatggt aggaactgaa aagcagtgaa gtggagatgc attttctagc
     2941 agtggcagag tgctgggcac acagtaggta atcacagcaa gcatgctgtt tgaatgtgtg
     3001 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtacatata tatggctctc
     3061 atttgggatt taagaacaat aacctcttct aatttttgct ttgctcaatc tttagtggaa
     3121 gcgtgatttt gagtgttatc aaaggaaggt catgtgggtg tggaaacaaa gagcatgttt
     3181 tcacattcta ctgtttaagg gcagagagtg acggcctcgt cactcttcgt cttgcatttc
     3241 actcacggct ctgccagtga aacagtaatg aaattgtccc tttctaatga catctatgca
     3301 gcaggggtct attgccttgt gggtgacacc aaattatcct acatattagg agatcagggc
     3361 ttttccttta atcccttctt attaaggagt gcatagtgcc gtacccaaga gacagctact
     3421 ggcagataca gagcagagag atcagagagg aaaaatcagg aaggcataaa agatttatac
     3481 gagccatgga acaacgccaa ctgtctgttc cctcaggagg agaacagagt caccccccaa
     3541 gtttcgaggt ggtccataca ctggaaaagt acacattctg tcaaaacaca gcagaaagga
     3601 atcttttttt taagattttg aggatttttt ttcaaatgta ggactctgac ttctaaatgt
     3661 gtgtttccat tttcttccaa atgttctacc ctttcacact ataagaaaat gttttctgta
     3721 gcctaagtca ctggtaattt tacaacttgt ttctgtgctt tgacactact cataaattct
     3781 ctccctttcg atcatcagag aagtgtcctt ccacatctca gagacactgc tggccagagc
     3841 tgctccctga tgaagatttc ataaggagat tagaaatctc tggaaagcat gcatgttaga
     3901 aatgagctga tttcttagag gtcaatttca aaagcgcaac acttctagga ggacccaggc
     3961 aatgtgtgca ctgctctaac cccactgatg gcagtgaaat ctcaaaaccg gggaactaat
     4021 taaaatgatg gcatgagacc ttgcctggcc ctttgttgtg tgacgttgac accttcctcc
     4081 cacatcagaa atctgacaga gacatgacct ctctgacaat tgaagacaga gagccaaata
     4141 gacaatctta taaaactatg agaggttctt atcattaaac cacaggatat atgaatgtgg
     4201 actcttggac ctgaaagtca ttacgtcttt ctccagtgaa ctcatgggat aaaatcttag
     4261 gaaagcatgg tttctctttg aaagtgtact ataacaactc acttccttta cgtcagcttt
     4321 ttgagctcat gtctgggtgt tactgctttt cagaacacct taaacaacac aaacctttca
     4381 aacccataac tctcagaaag aaatgttagg cacttaactt caaaactcaa aaactgtgaa
     4441 tactcacttt tggcacataa cttccctgaa aacactcacc caacaaatga tacaacgcat
     4501 accatgaaca ctagatttaa gagcagttat agtgttactg ttttaagtca aaattcaaga
     4561 gctaaaaaat atacctaaca tatatattcc attgaaatgt attcctagac tgttctcatg
     4621 tttgatcaaa taaacagcaa tttatggaaa tatgtaaaca attatttatc attttatcac
     4681 ccagatcacg ataaacctgc aacttatgag gaactaagaa aaataaaatg aatgcctggt
     4741 tatatttaca attatttatt aacttaatat tattgcaaaa ttagagttaa tgttaaatgg
     4801 atttaaactg taatgactaa tatttggaaa atctaataaa agtgttagct gtg
//
LOCUS       NM_001317749            5010 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.
ACCESSION   NM_001317749
VERSION     NM_001317749.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5010)
  AUTHORS   Chen,K., Xu,B., Qiu,S., Long,L., Zhao,Q., Xu,J. and Wang,H.
  TITLE     Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression
            and astrocyte swelling following cerebral ischemia/reperfusion
            injury
  JOURNAL   Glia 72 (9), 1629-1645 (2024)
   PUBMED   38785370
  REMARK    GeneRIF: Inhibition of phosphodiesterase 4 attenuates aquaporin 4
            expression and astrocyte swelling following cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 5010)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   3  (bases 1 to 5010)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   4  (bases 1 to 5010)
  AUTHORS   Pisani,F., Rossi,A., Nicchia,G.P., Svelto,M. and Frigeri,A.
  TITLE     Translational regulation mechanisms of aquaporin-4 supramolecular
            organization in astrocytes
  JOURNAL   Glia 59 (12), 1923-1932 (2011)
   PUBMED   21850708
  REMARK    GeneRIF: When transfected in Hela cells, the longer rat AQP4
            isoform, not present in humans, impairs formation of the orthogonal
            array of particles in astrocyte primary cultures.
REFERENCE   5  (bases 1 to 5010)
  AUTHORS   Hirt,B., Gleiser,C., Eckhard,A., Mack,A.F., Muller,M., Wolburg,H.
            and Lowenheim,H.
  TITLE     All functional aquaporin-4 isoforms are expressed in the rat
            cochlea and contribute to the formation of orthogonal arrays of
            particles
  JOURNAL   Neuroscience 189, 79-92 (2011)
   PUBMED   21621589
  REMARK    GeneRIF: Identified all functional AQP4 isoforms -M1, M23, and Mz-
            and the formation of higher-order complexes in the organ of Corti
            of the rat.
REFERENCE   6  (bases 1 to 5010)
  AUTHORS   Moe,S.E., Sorbo,J.G., Sogaard,R., Zeuthen,T., Petter Ottersen,O.
            and Holen,T.
  TITLE     New isoforms of rat Aquaporin-4
  JOURNAL   Genomics 91 (4), 367-377 (2008)
   PUBMED   18255256
  REMARK    GeneRIF: rat AQP4 has six cDNA isoforms, formed by alternative
            splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond
            to the two classical M1 and M23 isoforms, respectively
REFERENCE   7  (bases 1 to 5010)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 5010)
  AUTHORS   Jung,J.S., Bhat,R.V., Preston,G.M., Guggino,W.B., Baraban,J.M. and
            Agre,P.
  TITLE     Molecular characterization of an aquaporin cDNA from brain:
            candidate osmoreceptor and regulator of water balance
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13052-13056 (1994)
   PUBMED   7528931
REFERENCE   9  (bases 1 to 5010)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 5010)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            Summary: This gene encodes a member of the aquaporin family of
            intrinsic membrane proteins that function as water-selective
            channels in the plasma membranes of many cells. This protein is the
            predominant aquaporin found in brain and has an important role in
            brain water homeostasis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene. A
            recent study provided evidence for translational readthrough in
            this gene and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1, also known as AQP4a)
            represents the predominant transcript and encodes two isoforms,
            which result from the use of alternative in-frame translation
            termination codons. The shorter isoform (M1) results from
            translation termination at the upstream UGA stop codon, while the
            longer isoform (M1x) results from UGA stop codon readthrough to the
            downstream UAA termination codon. This RefSeq represents the
            longer, C-terminally extended isoform (M1x). As the UGA stop codon
            has been reported to specify several alternative amino acids
            (tryptophan, cysteine, arginine and serine), its location in the
            longer isoform is denoted by an 'X'.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.72618.1,
                                           SRR26643429.53390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF        :: PMID: 21850708
            stop codon readthrough :: inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000018.1  6798745-6798842     c
            99-513              JAXUCZ010000018.1  6794980-6795394     c
            514-678             JAXUCZ010000018.1  6793452-6793616     c
            679-759             JAXUCZ010000018.1  6792936-6793016     c
            760-5010            JAXUCZ010000018.1  6782389-6786639     c
FEATURES             Location/Qualifiers
     source          1..5010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..5010
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="aquaporin 4"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
     exon            1..98
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      38..70
                     /regulatory_class="uORF"
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21850708]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:21850708)"
     CDS             67..1125
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="isoform M1x is encoded by transcript variant 1;
                     mercurial-insensitive water channel"
                     /codon_start=1
                     /transl_except=(pos:1036..1038,aa:OTHER)
                     /product="aquaporin-4 isoform M1x"
                     /protein_id="NP_001304678.1"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
                     /translation="MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLA
                     MLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTV
                     AMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGL
                     LVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSF
                     GPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGS
                     YMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSVXLEDSTENRRD
                     SLELASDFLPPIKETDLL"
     misc_feature    133..135
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Region: alternative AUG translation initiation
                     site"
     misc_feature    157..810
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    157..810
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    order(295..297,349..357,691..696,703..705,712..714)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(295..297,349..357,691..696,703..705,712..714)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,703..711)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,703..711)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            99..513
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..678
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..759
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..5010
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1036..1038
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="upstream translation termination codon, use of
                     which results in the shorter isoform M1"
     regulatory      1039..1042
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="stop_codon_readthrough_signal"
                     /function="stimulates stop codon readthrough"
ORIGIN      
        1 aatctgattc ccgagcactg gagcctgggg gcaggcaatg agagctgcac tccggccagg
       61 gaaggcatga gtgacggagc tgcagcgagg cggtggggta agtgtggacc tccctgcagc
      121 agagagagca tcatggtggc tttcaaaggc gtctggactc aagccttctg gaaggcggtc
      181 acagcagagt tcctggccat gctcatcttt gttctgctca gcgtgggatc caccattaac
      241 tggggtggct cagagaaccc cctacctgtg gacatggtcc tcatctccct ctgctttgga
      301 ctcagcattg ccaccatggt tcagtgcttc ggccacatca gcggtggcca catcaaccca
      361 gcggtgacag tggccatggt gtgcacacga aagatcagca tcgccaagtc cgtcttctac
      421 atcactgcgc agtgcctggg ggccatcatc ggagctggga tcctctacct ggtcacaccc
      481 cccagcgtgg tgggaggatt gggagtcacc acggttcatg gaaacctcac tgctggccat
      541 gggctcctgg tggagctaat aatcactttc cagctggtat tcaccatttt tgccagctgt
      601 gattccaaac ggactgatgt tactggttcc gttgctttag caattgggtt ttccgttgca
      661 attggacatt tgtttgcaat caattatacc ggagccagca tgaatccagc tcgatccttt
      721 ggccctgcag ttatcatggg aaactgggaa aaccactgga tatattgggt tggaccaatc
      781 ataggcgctg tgctggcagg tgcactttac gagtatgtct tctgtcctga cgtggagctc
      841 aaacgtcgcc taaaggaagc cttcagcaaa gctgcacagc agacgaaagg gagctacatg
      901 gaggtggagg acaaccggag ccaagtggag acagaagact tgatcctgaa gcccggggtg
      961 gtgcatgtga tcgacattga ccgtggagac gagaagaagg ggaaggactc gtctggagag
     1021 gtattatctt ctgtatgact agaggacagc actgaaaaca gaagagactc cctagaactg
     1081 gcctcagatt tcctgccacc cattaaggaa acagatttgt tataaattag acatatgcgg
     1141 gtttcttgtt tcacatcttg ttacacagct taaataacac atattttact attatcaatg
     1201 ggggggagaa gcctataatt aatatgacat tttaatggaa atctttttta atgtatcctc
     1261 gaagcaaata ttcagctact gtattgactt tccttttgtt agtaataact gaaactatga
     1321 gccgaaatct gatcaagtct tacttaacag agcattggac atctctgtga ggaagcttgt
     1381 actgcccatc ctcacttcaa aactgacacc attagattga tttaaaaatg acaaaatgca
     1441 gcacatcacc gaatcatgtg cgttttagga gaagaaatgt agtaagttct tccacaagct
     1501 atcccttact tattaactac cttggaggag ttaaaaatag cacttgccat tgctaatata
     1561 tcatgcgtat ttatatagct gactgtcaga tcccaacccc aattcactat aatccttctt
     1621 ccccctcagc atccaagaaa ccatagaact aaaagtcaaa agaaatggaa agaatattaa
     1681 cttctgtcca tgtgttggtt tcatctaatg aaacctgtac atgggacacc cacccactga
     1741 ggttcaggac agccagacct ggggagtctg gtgggaggtg gagcaaaggt tgctacttac
     1801 agtcctacaa ccatcacaag aggggcaacc tctgttatga aatgattgct ctgttttcag
     1861 tgcacactct taaggatacc acaaaagatt aactgcctaa gcctttaact acttcacttg
     1921 cttttaaagc ttatttgcaa aattggggaa tttgtttgcc atttgggcac ctatactgaa
     1981 acactagctg agatatttta gatgacaact tgactagttg agtcctgcct ttctgttggt
     2041 gtctaaatcc tgcttactct aggtggtata aaccagtcct gccccgtgcc aactgctaat
     2101 gcttcccatg acatctgttg atggtcagca ttgtgagtgt aataataccc attggtgtgg
     2161 attaaaatat atggcagata aggtgcaagg tagctgccaa taaaggtgtg agcagacagc
     2221 ctctgtgcaa agctcctagg tgccccatca gcacagagtg tacgtgcttt taaggtattt
     2281 acctcctgcc tgatttattt gttagaacca tttgtttttc ccatactgct ttgccttccg
     2341 cccgtcgaat gctctgtgga aaccccagtt tctacactca tagcagtcta gcctaacatt
     2401 tattttagac aaagtgctgt aaacgtcaat ttcaccaaac aaaagtcagt agtgggagag
     2461 agaagagcca cctcttcaag gactaacttg taaatagctg atcatcaggg ctttcttctc
     2521 ccaagcacaa ttccagctgc gtgtgacttc ttattgttaa tggcagtttt gtgtctgtgg
     2581 cagcaagata atggaccact attaaagttg attctcttcg gtgctaggaa actgatatgc
     2641 aagttcccag acagccacga ggacagcata tgcctctcag agccacgggc gtattctgag
     2701 gtagatgctg ggagcatagg cctcatttca gggctttgaa tgtactacac cagagacata
     2761 agcttcctct ctgatcagaa cctacagaac caaggcgtag accggtgttt tcacaatata
     2821 ccacatgggc ttaagatcag ggtgctccag tcggaaggtg ataaccttca acaaacatgt
     2881 tgggttaaaa ccaaattagg ggtcgggtca aaaataaatt cagttaacca ggaatagtgg
     2941 ggcacatttc tgattacttt ttcaaaatcc tggcctgtga ttatttttat tatgctacac
     3001 agcttgcatt gtgtgctcac tttctcagtc atttccaggg acagcatcca atatggtagg
     3061 aactgaaaag cagtgaagtg gagatgcatt ttctagcagt ggcagagtgc tgggcacaca
     3121 gtaggtaatc acagcaagca tgctgtttga atgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt acatatatat ggctctcatt tgggatttaa gaacaataac
     3241 ctcttctaat ttttgctttg ctcaatcttt agtggaagcg tgattttgag tgttatcaaa
     3301 ggaaggtcat gtgggtgtgg aaacaaagag catgttttca cattctactg tttaagggca
     3361 gagagtgacg gcctcgtcac tcttcgtctt gcatttcact cacggctctg ccagtgaaac
     3421 agtaatgaaa ttgtcccttt ctaatgacat ctatgcagca ggggtctatt gccttgtggg
     3481 tgacaccaaa ttatcctaca tattaggaga tcagggcttt tcctttaatc ccttcttatt
     3541 aaggagtgca tagtgccgta cccaagagac agctactggc agatacagag cagagagatc
     3601 agagaggaaa aatcaggaag gcataaaaga tttatacgag ccatggaaca acgccaactg
     3661 tctgttccct caggaggaga acagagtcac cccccaagtt tcgaggtggt ccatacactg
     3721 gaaaagtaca cattctgtca aaacacagca gaaaggaatc ttttttttaa gattttgagg
     3781 attttttttc aaatgtagga ctctgacttc taaatgtgtg tttccatttt cttccaaatg
     3841 ttctaccctt tcacactata agaaaatgtt ttctgtagcc taagtcactg gtaattttac
     3901 aacttgtttc tgtgctttga cactactcat aaattctctc cctttcgatc atcagagaag
     3961 tgtccttcca catctcagag acactgctgg ccagagctgc tccctgatga agatttcata
     4021 aggagattag aaatctctgg aaagcatgca tgttagaaat gagctgattt cttagaggtc
     4081 aatttcaaaa gcgcaacact tctaggagga cccaggcaat gtgtgcactg ctctaacccc
     4141 actgatggca gtgaaatctc aaaaccgggg aactaattaa aatgatggca tgagaccttg
     4201 cctggccctt tgttgtgtga cgttgacacc ttcctcccac atcagaaatc tgacagagac
     4261 atgacctctc tgacaattga agacagagag ccaaatagac aatcttataa aactatgaga
     4321 ggttcttatc attaaaccac aggatatatg aatgtggact cttggacctg aaagtcatta
     4381 cgtctttctc cagtgaactc atgggataaa atcttaggaa agcatggttt ctctttgaaa
     4441 gtgtactata acaactcact tcctttacgt cagctttttg agctcatgtc tgggtgttac
     4501 tgcttttcag aacaccttaa acaacacaaa cctttcaaac ccataactct cagaaagaaa
     4561 tgttaggcac ttaacttcaa aactcaaaaa ctgtgaatac tcacttttgg cacataactt
     4621 ccctgaaaac actcacccaa caaatgatac aacgcatacc atgaacacta gatttaagag
     4681 cagttatagt gttactgttt taagtcaaaa ttcaagagct aaaaaatata cctaacatat
     4741 atattccatt gaaatgtatt cctagactgt tctcatgttt gatcaaataa acagcaattt
     4801 atggaaatat gtaaacaatt atttatcatt ttatcaccca gatcacgata aacctgcaac
     4861 ttatgaggaa ctaagaaaaa taaaatgaat gcctggttat atttacaatt atttattaac
     4921 ttaatattat tgcaaaatta gagttaatgt taaatggatt taaactgtaa tgactaatat
     4981 ttggaaaatc taataaaagt gttagctgtg
//
LOCUS       NM_012825               5010 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.
ACCESSION   NM_012825
VERSION     NM_012825.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5010)
  AUTHORS   Chen,K., Xu,B., Qiu,S., Long,L., Zhao,Q., Xu,J. and Wang,H.
  TITLE     Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression
            and astrocyte swelling following cerebral ischemia/reperfusion
            injury
  JOURNAL   Glia 72 (9), 1629-1645 (2024)
   PUBMED   38785370
  REMARK    GeneRIF: Inhibition of phosphodiesterase 4 attenuates aquaporin 4
            expression and astrocyte swelling following cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 5010)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   3  (bases 1 to 5010)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   4  (bases 1 to 5010)
  AUTHORS   Pisani,F., Rossi,A., Nicchia,G.P., Svelto,M. and Frigeri,A.
  TITLE     Translational regulation mechanisms of aquaporin-4 supramolecular
            organization in astrocytes
  JOURNAL   Glia 59 (12), 1923-1932 (2011)
   PUBMED   21850708
  REMARK    GeneRIF: When transfected in Hela cells, the longer rat AQP4
            isoform, not present in humans, impairs formation of the orthogonal
            array of particles in astrocyte primary cultures.
REFERENCE   5  (bases 1 to 5010)
  AUTHORS   Hirt,B., Gleiser,C., Eckhard,A., Mack,A.F., Muller,M., Wolburg,H.
            and Lowenheim,H.
  TITLE     All functional aquaporin-4 isoforms are expressed in the rat
            cochlea and contribute to the formation of orthogonal arrays of
            particles
  JOURNAL   Neuroscience 189, 79-92 (2011)
   PUBMED   21621589
  REMARK    GeneRIF: Identified all functional AQP4 isoforms -M1, M23, and Mz-
            and the formation of higher-order complexes in the organ of Corti
            of the rat.
REFERENCE   6  (bases 1 to 5010)
  AUTHORS   Moe,S.E., Sorbo,J.G., Sogaard,R., Zeuthen,T., Petter Ottersen,O.
            and Holen,T.
  TITLE     New isoforms of rat Aquaporin-4
  JOURNAL   Genomics 91 (4), 367-377 (2008)
   PUBMED   18255256
  REMARK    GeneRIF: rat AQP4 has six cDNA isoforms, formed by alternative
            splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond
            to the two classical M1 and M23 isoforms, respectively
REFERENCE   7  (bases 1 to 5010)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 5010)
  AUTHORS   Jung,J.S., Bhat,R.V., Preston,G.M., Guggino,W.B., Baraban,J.M. and
            Agre,P.
  TITLE     Molecular characterization of an aquaporin cDNA from brain:
            candidate osmoreceptor and regulator of water balance
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13052-13056 (1994)
   PUBMED   7528931
REFERENCE   9  (bases 1 to 5010)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 5010)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            On Aug 28, 2014 this sequence version replaced NM_012825.3.
            
            Summary: This gene encodes a member of the aquaporin family of
            intrinsic membrane proteins that function as water-selective
            channels in the plasma membranes of many cells. This protein is the
            predominant aquaporin found in brain and has an important role in
            brain water homeostasis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene. A
            recent study provided evidence for translational readthrough in
            this gene and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1, also known as AQP4a)
            represents the predominant transcript and encodes two isoforms,
            which result from the use of alternative in-frame translation
            termination codons. The shorter isoform (M1) results from
            translation termination at the upstream UGA stop codon, while the
            longer isoform (M1x) results from UGA stop codon readthrough to the
            downstream UAA termination codon. This RefSeq represents the
            shorter isoform (M1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.72618.1,
                                           SRR26643429.53390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 21850708
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000018.1  6798745-6798842     c
            99-513              JAXUCZ010000018.1  6794980-6795394     c
            514-678             JAXUCZ010000018.1  6793452-6793616     c
            679-759             JAXUCZ010000018.1  6792936-6793016     c
            760-5010            JAXUCZ010000018.1  6782389-6786639     c
FEATURES             Location/Qualifiers
     source          1..5010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..5010
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="aquaporin 4"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
     exon            1..98
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      38..70
                     /regulatory_class="uORF"
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21850708]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:21850708)"
     CDS             67..1038
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="isoform M1 is encoded by transcript variant 1;
                     mercurial-insensitive water channel"
                     /codon_start=1
                     /product="aquaporin-4 isoform M1"
                     /protein_id="NP_036957.1"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
                     /translation="MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLA
                     MLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTV
                     AMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGL
                     LVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSF
                     GPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGS
                     YMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV"
     misc_feature    133..135
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Region: alternative AUG translation initiation
                     site"
     misc_feature    157..810
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    157..810
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    175..237
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    274..333
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    order(295..297,349..357,691..696,703..705,712..714)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(295..297,349..357,691..696,703..705,712..714)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,703..711)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(355..363,703..711)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    355..363
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     Region: NPA 1. /evidence=ECO:0000305|PubMed:16325200,
                     ECO:0000305|PubMed:19406128"
     misc_feature    397..399
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphoserine, by PKG.
                     /evidence=ECO:0000250|UniProtKB:P55088; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     misc_feature    412..474
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    523..525
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); glycosylation site"
     misc_feature    532..594
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    604..606
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:19800950; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     misc_feature    619..681
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    703..711
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     Region: NPA 2. /evidence=ECO:0000305|PubMed:16325200,
                     ECO:0000305|PubMed:19406128"
     misc_feature    760..822
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="propagated from UniProtKB/Swiss-Prot (P47863.1);
                     transmembrane region"
     misc_feature    892..894
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     misc_feature    919..921
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:12692561,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     misc_feature    931..933
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P55088; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     misc_feature    1027..1029
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P47863.1); phosphorylation site"
     exon            99..513
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..678
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..759
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..5010
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1123..1125
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="alternative translation termination codon, use of
                     which results in the longer, C-terminally extended isoform
                     M1x"
ORIGIN      
        1 aatctgattc ccgagcactg gagcctgggg gcaggcaatg agagctgcac tccggccagg
       61 gaaggcatga gtgacggagc tgcagcgagg cggtggggta agtgtggacc tccctgcagc
      121 agagagagca tcatggtggc tttcaaaggc gtctggactc aagccttctg gaaggcggtc
      181 acagcagagt tcctggccat gctcatcttt gttctgctca gcgtgggatc caccattaac
      241 tggggtggct cagagaaccc cctacctgtg gacatggtcc tcatctccct ctgctttgga
      301 ctcagcattg ccaccatggt tcagtgcttc ggccacatca gcggtggcca catcaaccca
      361 gcggtgacag tggccatggt gtgcacacga aagatcagca tcgccaagtc cgtcttctac
      421 atcactgcgc agtgcctggg ggccatcatc ggagctggga tcctctacct ggtcacaccc
      481 cccagcgtgg tgggaggatt gggagtcacc acggttcatg gaaacctcac tgctggccat
      541 gggctcctgg tggagctaat aatcactttc cagctggtat tcaccatttt tgccagctgt
      601 gattccaaac ggactgatgt tactggttcc gttgctttag caattgggtt ttccgttgca
      661 attggacatt tgtttgcaat caattatacc ggagccagca tgaatccagc tcgatccttt
      721 ggccctgcag ttatcatggg aaactgggaa aaccactgga tatattgggt tggaccaatc
      781 ataggcgctg tgctggcagg tgcactttac gagtatgtct tctgtcctga cgtggagctc
      841 aaacgtcgcc taaaggaagc cttcagcaaa gctgcacagc agacgaaagg gagctacatg
      901 gaggtggagg acaaccggag ccaagtggag acagaagact tgatcctgaa gcccggggtg
      961 gtgcatgtga tcgacattga ccgtggagac gagaagaagg ggaaggactc gtctggagag
     1021 gtattatctt ctgtatgact agaggacagc actgaaaaca gaagagactc cctagaactg
     1081 gcctcagatt tcctgccacc cattaaggaa acagatttgt tataaattag acatatgcgg
     1141 gtttcttgtt tcacatcttg ttacacagct taaataacac atattttact attatcaatg
     1201 ggggggagaa gcctataatt aatatgacat tttaatggaa atctttttta atgtatcctc
     1261 gaagcaaata ttcagctact gtattgactt tccttttgtt agtaataact gaaactatga
     1321 gccgaaatct gatcaagtct tacttaacag agcattggac atctctgtga ggaagcttgt
     1381 actgcccatc ctcacttcaa aactgacacc attagattga tttaaaaatg acaaaatgca
     1441 gcacatcacc gaatcatgtg cgttttagga gaagaaatgt agtaagttct tccacaagct
     1501 atcccttact tattaactac cttggaggag ttaaaaatag cacttgccat tgctaatata
     1561 tcatgcgtat ttatatagct gactgtcaga tcccaacccc aattcactat aatccttctt
     1621 ccccctcagc atccaagaaa ccatagaact aaaagtcaaa agaaatggaa agaatattaa
     1681 cttctgtcca tgtgttggtt tcatctaatg aaacctgtac atgggacacc cacccactga
     1741 ggttcaggac agccagacct ggggagtctg gtgggaggtg gagcaaaggt tgctacttac
     1801 agtcctacaa ccatcacaag aggggcaacc tctgttatga aatgattgct ctgttttcag
     1861 tgcacactct taaggatacc acaaaagatt aactgcctaa gcctttaact acttcacttg
     1921 cttttaaagc ttatttgcaa aattggggaa tttgtttgcc atttgggcac ctatactgaa
     1981 acactagctg agatatttta gatgacaact tgactagttg agtcctgcct ttctgttggt
     2041 gtctaaatcc tgcttactct aggtggtata aaccagtcct gccccgtgcc aactgctaat
     2101 gcttcccatg acatctgttg atggtcagca ttgtgagtgt aataataccc attggtgtgg
     2161 attaaaatat atggcagata aggtgcaagg tagctgccaa taaaggtgtg agcagacagc
     2221 ctctgtgcaa agctcctagg tgccccatca gcacagagtg tacgtgcttt taaggtattt
     2281 acctcctgcc tgatttattt gttagaacca tttgtttttc ccatactgct ttgccttccg
     2341 cccgtcgaat gctctgtgga aaccccagtt tctacactca tagcagtcta gcctaacatt
     2401 tattttagac aaagtgctgt aaacgtcaat ttcaccaaac aaaagtcagt agtgggagag
     2461 agaagagcca cctcttcaag gactaacttg taaatagctg atcatcaggg ctttcttctc
     2521 ccaagcacaa ttccagctgc gtgtgacttc ttattgttaa tggcagtttt gtgtctgtgg
     2581 cagcaagata atggaccact attaaagttg attctcttcg gtgctaggaa actgatatgc
     2641 aagttcccag acagccacga ggacagcata tgcctctcag agccacgggc gtattctgag
     2701 gtagatgctg ggagcatagg cctcatttca gggctttgaa tgtactacac cagagacata
     2761 agcttcctct ctgatcagaa cctacagaac caaggcgtag accggtgttt tcacaatata
     2821 ccacatgggc ttaagatcag ggtgctccag tcggaaggtg ataaccttca acaaacatgt
     2881 tgggttaaaa ccaaattagg ggtcgggtca aaaataaatt cagttaacca ggaatagtgg
     2941 ggcacatttc tgattacttt ttcaaaatcc tggcctgtga ttatttttat tatgctacac
     3001 agcttgcatt gtgtgctcac tttctcagtc atttccaggg acagcatcca atatggtagg
     3061 aactgaaaag cagtgaagtg gagatgcatt ttctagcagt ggcagagtgc tgggcacaca
     3121 gtaggtaatc acagcaagca tgctgtttga atgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt acatatatat ggctctcatt tgggatttaa gaacaataac
     3241 ctcttctaat ttttgctttg ctcaatcttt agtggaagcg tgattttgag tgttatcaaa
     3301 ggaaggtcat gtgggtgtgg aaacaaagag catgttttca cattctactg tttaagggca
     3361 gagagtgacg gcctcgtcac tcttcgtctt gcatttcact cacggctctg ccagtgaaac
     3421 agtaatgaaa ttgtcccttt ctaatgacat ctatgcagca ggggtctatt gccttgtggg
     3481 tgacaccaaa ttatcctaca tattaggaga tcagggcttt tcctttaatc ccttcttatt
     3541 aaggagtgca tagtgccgta cccaagagac agctactggc agatacagag cagagagatc
     3601 agagaggaaa aatcaggaag gcataaaaga tttatacgag ccatggaaca acgccaactg
     3661 tctgttccct caggaggaga acagagtcac cccccaagtt tcgaggtggt ccatacactg
     3721 gaaaagtaca cattctgtca aaacacagca gaaaggaatc ttttttttaa gattttgagg
     3781 attttttttc aaatgtagga ctctgacttc taaatgtgtg tttccatttt cttccaaatg
     3841 ttctaccctt tcacactata agaaaatgtt ttctgtagcc taagtcactg gtaattttac
     3901 aacttgtttc tgtgctttga cactactcat aaattctctc cctttcgatc atcagagaag
     3961 tgtccttcca catctcagag acactgctgg ccagagctgc tccctgatga agatttcata
     4021 aggagattag aaatctctgg aaagcatgca tgttagaaat gagctgattt cttagaggtc
     4081 aatttcaaaa gcgcaacact tctaggagga cccaggcaat gtgtgcactg ctctaacccc
     4141 actgatggca gtgaaatctc aaaaccgggg aactaattaa aatgatggca tgagaccttg
     4201 cctggccctt tgttgtgtga cgttgacacc ttcctcccac atcagaaatc tgacagagac
     4261 atgacctctc tgacaattga agacagagag ccaaatagac aatcttataa aactatgaga
     4321 ggttcttatc attaaaccac aggatatatg aatgtggact cttggacctg aaagtcatta
     4381 cgtctttctc cagtgaactc atgggataaa atcttaggaa agcatggttt ctctttgaaa
     4441 gtgtactata acaactcact tcctttacgt cagctttttg agctcatgtc tgggtgttac
     4501 tgcttttcag aacaccttaa acaacacaaa cctttcaaac ccataactct cagaaagaaa
     4561 tgttaggcac ttaacttcaa aactcaaaaa ctgtgaatac tcacttttgg cacataactt
     4621 ccctgaaaac actcacccaa caaatgatac aacgcatacc atgaacacta gatttaagag
     4681 cagttatagt gttactgttt taagtcaaaa ttcaagagct aaaaaatata cctaacatat
     4741 atattccatt gaaatgtatt cctagactgt tctcatgttt gatcaaataa acagcaattt
     4801 atggaaatat gtaaacaatt atttatcatt ttatcaccca gatcacgata aacctgcaac
     4861 ttatgaggaa ctaagaaaaa taaaatgaat gcctggttat atttacaatt atttattaac
     4921 ttaatattat tgcaaaatta gagttaatgt taaatggatt taaactgtaa tgactaatat
     4981 ttggaaaatc taataaaagt gttagctgtg
//
LOCUS       NM_001304735            2390 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1H1, mRNA.
ACCESSION   NM_001304735
VERSION     NM_001304735.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2390)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2390)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2390)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2390)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2390)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2390)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2390)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2390)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2390)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2390)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1H1) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1) is shorter
            than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU340244.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000001.1  45565371-45565531
            162-575             JAXUCZ010000001.1  45586060-45586473
            576-928             JAXUCZ010000001.1  45617450-45617802
            929-1449            JAXUCZ010000001.1  45618567-45619087
            1450-2390           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2390
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..161
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    91..93
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     exon            162..575
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1488
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant MOR-1H1;
                     mu-type opioid receptor; MUOR1; opioid receptor B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_001291664.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     misc_feature    316..318
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    382..384
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    403..405
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    427..429
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    448..450
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    490..564
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    496..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    496..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    499..579
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    499..579
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    598..678
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    598..678
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    604..678
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(661..663,670..675,709..726,730..735,742..744,
                     877..879,883..897,976..978,985..993,997..1005,1009..1014,
                     1168..1170,1177..1182,1186..1191,1198..1200,1231..1236,
                     1240..1248,1255..1257,1264..1269)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(661..663,670..675,709..726,730..735,742..744,
                     877..879,883..897,976..978,985..993,997..1005,1009..1014,
                     1168..1170,1177..1182,1186..1191,1198..1200,1231..1236,
                     1240..1248,1255..1257,1264..1269)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    709..801
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    709..801
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    712..780
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    787..789
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    835..903
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    835..903
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    841..906
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    976..1065
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    976..1065
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    976..1050
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1108..1200
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1108..1200
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1123..1203
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1228..1299
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1234..1311
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1234..1311
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1285..1299
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1372..1446
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1378..1380
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1399..1401
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1414..1416
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1471..1473
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            576..928
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1449
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..2390
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctg taagctttct ccaagtccgc attccaaaaa
      121 ctggacaggg agatagaaat caagagggga agttacctca gggctggtcc atgtaagaat
      181 ctgacggagc ctagggcagc tgtgagagga agaggctggg gcgcgtggaa cccgaaaagt
      241 ctgagtgctc tcagttacag cctacctagt ccgcagcagg ccttcagcac catggacagc
      301 agcaccggcc cagggaacac cagcgactgc tcagacccct tagctcaggc aagttgctcc
      361 ccagcacctg gctcctggct caacttgtcc cacgttgatg gcaaccagtc cgatccatgc
      421 ggtctgaacc gcaccgggct tggcgggaac gacagcctgt gccctcagac cggcagccct
      481 tccatggtca cagccattac catcatggcc ctctactcta tcgtgtgtgt agtgggcctc
      541 ttcggaaact tcctggtcat gtatgtgatt gtaagataca ccaaaatgaa gactgccacc
      601 aacatctaca ttttcaacct tgctctggca gacgccttag cgaccagtac actgcccttt
      661 cagagtgtca actacctgat gggaacatgg cccttcggaa ccatcctctg caagatcgtg
      721 atctcaatag attactacaa catgttcacc agcatattca ccctctgcac catgagcgtg
      781 gaccgctaca ttgctgtctg ccacccagtc aaagccctgg atttccgtac cccccgaaat
      841 gccaaaatcg tcaacgtctg caactggatc ctctcttctg ccatcggtct gcctgtaatg
      901 ttcatggcaa ccacaaaata caggcagggg tccatagatt gcaccctcac gttctcccac
      961 ccaacctggt actgggagaa cctgctcaaa atctgtgtct ttatcttcgc tttcatcatg
     1021 ccggtcctca tcatcactgt gtgttacggc ctgatgatct tacgactcaa gagcgttcgc
     1081 atgctatcgg gctccaaaga aaaggacagg aatctgcgca ggatcacccg gatggtgctg
     1141 gtggtcgtgg ctgtatttat cgtctgctgg acccccatcc acatctacgt catcatcaaa
     1201 gcgctgatca cgattccaga aaccacattt cagaccgttt cctggcactt ctgcattgct
     1261 ttgggttaca cgaacagctg cctgaatcca gttctttacg ccttcctgga tgaaaacttc
     1321 aagcgatgct tcagagagtt ctgcatccca acctcgtcca cgatcgaaca gcaaaactcc
     1381 actcgagtcc gtcagaacac tagggaacat ccctccacgg ctaatacagt ggatcgaact
     1441 aaccaccagc tagaaaatct ggaggcagaa actgctccat tgccctaact gggtctcaca
     1501 ccatccagac cctcgctaag cttagaggcc gccatctacg tggaatcagg ttgctgtcag
     1561 ggtgtgtggg aggctctggt ttcctgagaa accatctgat cctgcattca aagtcattcc
     1621 tctctggcta cttcactctg cacatgagag atgctcagac tgtatcaagt actcagaaag
     1681 aagagactac cggacactcc tgaatccagc tcatgtacag aaccatctga aacacccagt
     1741 ggaccacaat gctctgtggt atgtgaattt cgatcatcat agaaggtgac ccctctctat
     1801 gtagaatttt tatttttcaa gcaaatactt atgacctcat caaagaaaat aatgtcactt
     1861 gttaaattca ctgtagtgat acataaagta aatgctacct ctgacctctg acccagtcac
     1921 cttctgtaga gagttccagt ccttttgtga tggaatacat catttccaac ttaaaacttt
     1981 caccttgaag ttatggtcta gttaagacat caggggcacc tccgtttctt ggttttgtat
     2041 tgtttgaaag aagacgacat cttcctcctt agctgtgtgt tgaaaatgaa agggattgaa
     2101 agcacagtgt caactgcaga atggttgatt ctcactctga aaggatttac ttcgagttat
     2161 aatgtggggg ttaggagagg ggctgttttt tcctaattcc caccatgtcc tctaagtgtt
     2221 cacaaggtca agttcagaag gtcacccagt gagttcatca tgctatcatt ctgagcagga
     2281 agccaagaat ttcgctctct tcattttttt cagtaatttc tccacactgc acgctctttt
     2341 gtattatttt ccctgatgcc ttatgaaaca gcatgatcaa acaacagatg
//
LOCUS       NM_013071               2306 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            1, mRNA.
ACCESSION   NM_013071
VERSION     NM_013071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1 and L20684.1.
            
            On Apr 20, 2007 this sequence version replaced NM_013071.1.
            
            Transcript Variant: This variant (1) lacks several exons and
            contains an alternate terminal exon compared to variant MOR-1C2.
            The encoded isoform (1) is shorter than isoform 1C2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20684.1, D16349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               L13069.1           3-941
            940-2306            L20684.1           763-2129
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2306
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1404
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mu-type opioid receptor; MOR-1; MUOR1; opioid receptor B;
                     M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1"
                     /protein_id="NP_037203.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCG
                     LNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA
                     TNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT
                     MSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCT
                     LTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR
                     RITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPV
                     LYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEA
                     ETAPLP"
     misc_feature    232..234
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    298..300
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    319..321
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    343..345
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    364..366
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); glycosylation site"
     misc_feature    406..480
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    412..1248
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    415..495
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    514..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    520..594
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(577..579,586..591,625..642,646..651,658..660,
                     793..795,799..813,892..894,901..909,913..921,925..930,
                     1084..1086,1093..1098,1102..1107,1114..1116,1147..1152,
                     1156..1164,1171..1173,1180..1185)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    625..717
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    628..696
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    703..705
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:19959593; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    751..819
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    757..822
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..981
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    892..966
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1024..1116
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    1039..1119
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1144..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     transmembrane region"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1150..1227
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    1201..1215
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: NPxxY, plays a role in stabilizing the activated
                     conformation of the receptor.
                     /evidence=ECO:0000250|UniProtKB:P42866"
     misc_feature    1288..1362
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="propagated from UniProtKB/Swiss-Prot (P33535.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1294..1296
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1315..1317
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1330..1332
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11278523; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     misc_feature    1387..1389
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000305|PubMed:10820022; propagated from
                     UniProtKB/Swiss-Prot (P33535.1); phosphorylation site"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..2306
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accagctaga aaatctggag
     1381 gcagaaactg ctccattgcc ctaactgggt ctcacaccat ccagaccctc gctaagctta
     1441 gaggccgcca tctacgtgga atcaggttgc tgtcagggtg tgtgggaggc tctggtttcc
     1501 tgagaaacca tctgatcctg cattcaaagt cattcctctc tggctacttc actctgcaca
     1561 tgagagatgc tcagactgta tcaagtactc agaaagaaga gactaccgga cactcctgaa
     1621 tccagctcat gtacagaacc atctgaaaca cccagtggac cacaatgctc tgtggtatgt
     1681 gaatttcgat catcatagaa ggtgacccct ctctatgtag aatttttatt tttcaagcaa
     1741 atacttatga cctcatcaaa gaaaataatg tcacttgtta aattcactgt agtgatacat
     1801 aaagtaaatg ctacctctga cctctgaccc agtcaccttc tgtagagagt tccagtcctt
     1861 ttgtgatgga atacatcatt tccaacttaa aactttcacc ttgaagttat ggtctagtta
     1921 agacatcagg ggcacctccg tttcttggtt ttgtattgtt tgaaagaaga cgacatcttc
     1981 ctccttagct gtgtgttgaa aatgaaaggg attgaaagca cagtgtcaac tgcagaatgg
     2041 ttgattctca ctctgaaagg atttacttcg agttataatg tgggggttag gagaggggct
     2101 gttttttcct aattcccacc atgtcctcta agtgttcaca aggtcaagtt cagaaggtca
     2161 cccagtgagt tcatcatgct atcattctga gcaggaagcc aagaatttcg ctctcttcat
     2221 ttttttcagt aatttctcca cactgcacgc tcttttgtat tattttccct gatgccttat
     2281 gaaacagcat gatcaaacaa cagatg
//
LOCUS       NM_001304733            1976 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1G1, mRNA.
ACCESSION   NM_001304733
VERSION     NM_001304733.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1G1) represents use of an
            alternate promoter and 5' UTR, uses a downstream start codon, and
            uses an alternate 3' exon, compared to variant MOR-1C2. The
            resulting isoform (1G1) is shorter than isoform 1C2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ680043.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000001.1  45565371-45565531
            162-514             JAXUCZ010000001.1  45617450-45617802
            515-1035            JAXUCZ010000001.1  45618567-45619087
            1036-1976           JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1976
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..161
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    91..93
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     exon            162..514
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1074
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1G1 is encoded by transcript variant
                     MOR-1G1; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1G1"
                     /protein_id="NP_001291662.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKI
                     VISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGL
                     PVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILR
                     LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTV
                     SWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHP
                     STANTVDRTNHQLENLEAETAPLP"
     misc_feature    172..918
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    172..918
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    184..264
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    184..264
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    order(247..249,256..261,295..312,316..321,328..330,
                     463..465,469..483,562..564,571..579,583..591,595..600,
                     754..756,763..768,772..777,784..786,817..822,826..834,
                     841..843,850..855)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(247..249,256..261,295..312,316..321,328..330,
                     463..465,469..483,562..564,571..579,583..591,595..600,
                     754..756,763..768,772..777,784..786,817..822,826..834,
                     841..843,850..855)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    295..387
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    295..387
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    421..489
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    421..489
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    562..651
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    562..651
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    694..786
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    694..786
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    820..897
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    820..897
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     exon            515..1035
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1976
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgctg taagctttct ccaagtccgc attccaaaaa
      121 ctggacaggg agatagaaat caagagggga agttacctca gatacaccaa aatgaagact
      181 gccaccaaca tctacatttt caaccttgct ctggcagacg ccttagcgac cagtacactg
      241 ccctttcaga gtgtcaacta cctgatggga acatggccct tcggaaccat cctctgcaag
      301 atcgtgatct caatagatta ctacaacatg ttcaccagca tattcaccct ctgcaccatg
      361 agcgtggacc gctacattgc tgtctgccac ccagtcaaag ccctggattt ccgtaccccc
      421 cgaaatgcca aaatcgtcaa cgtctgcaac tggatcctct cttctgccat cggtctgcct
      481 gtaatgttca tggcaaccac aaaatacagg caggggtcca tagattgcac cctcacgttc
      541 tcccacccaa cctggtactg ggagaacctg ctcaaaatct gtgtctttat cttcgctttc
      601 atcatgccgg tcctcatcat cactgtgtgt tacggcctga tgatcttacg actcaagagc
      661 gttcgcatgc tatcgggctc caaagaaaag gacaggaatc tgcgcaggat cacccggatg
      721 gtgctggtgg tcgtggctgt atttatcgtc tgctggaccc ccatccacat ctacgtcatc
      781 atcaaagcgc tgatcacgat tccagaaacc acatttcaga ccgtttcctg gcacttctgc
      841 attgctttgg gttacacgaa cagctgcctg aatccagttc tttacgcctt cctggatgaa
      901 aacttcaagc gatgcttcag agagttctgc atcccaacct cgtccacgat cgaacagcaa
      961 aactccactc gagtccgtca gaacactagg gaacatccct ccacggctaa tacagtggat
     1021 cgaactaacc accagctaga aaatctggag gcagaaactg ctccattgcc ctaactgggt
     1081 ctcacaccat ccagaccctc gctaagctta gaggccgcca tctacgtgga atcaggttgc
     1141 tgtcagggtg tgtgggaggc tctggtttcc tgagaaacca tctgatcctg cattcaaagt
     1201 cattcctctc tggctacttc actctgcaca tgagagatgc tcagactgta tcaagtactc
     1261 agaaagaaga gactaccgga cactcctgaa tccagctcat gtacagaacc atctgaaaca
     1321 cccagtggac cacaatgctc tgtggtatgt gaatttcgat catcatagaa ggtgacccct
     1381 ctctatgtag aatttttatt tttcaagcaa atacttatga cctcatcaaa gaaaataatg
     1441 tcacttgtta aattcactgt agtgatacat aaagtaaatg ctacctctga cctctgaccc
     1501 agtcaccttc tgtagagagt tccagtcctt ttgtgatgga atacatcatt tccaacttaa
     1561 aactttcacc ttgaagttat ggtctagtta agacatcagg ggcacctccg tttcttggtt
     1621 ttgtattgtt tgaaagaaga cgacatcttc ctccttagct gtgtgttgaa aatgaaaggg
     1681 attgaaagca cagtgtcaac tgcagaatgg ttgattctca ctctgaaagg atttacttcg
     1741 agttataatg tgggggttag gagaggggct gttttttcct aattcccacc atgtcctcta
     1801 agtgttcaca aggtcaagtt cagaaggtca cccagtgagt tcatcatgct atcattctga
     1861 gcaggaagcc aagaatttcg ctctcttcat ttttttcagt aatttctcca cactgcacgc
     1921 tcttttgtat tattttccct gatgccttat gaaacagcat gatcaaacaa cagatg
//
LOCUS       NM_001142366            5018 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 2, mRNA.
ACCESSION   NM_001142366
VERSION     NM_001142366.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Chen,K., Xu,B., Qiu,S., Long,L., Zhao,Q., Xu,J. and Wang,H.
  TITLE     Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression
            and astrocyte swelling following cerebral ischemia/reperfusion
            injury
  JOURNAL   Glia 72 (9), 1629-1645 (2024)
   PUBMED   38785370
  REMARK    GeneRIF: Inhibition of phosphodiesterase 4 attenuates aquaporin 4
            expression and astrocyte swelling following cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 5018)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   3  (bases 1 to 5018)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   4  (bases 1 to 5018)
  AUTHORS   Pisani,F., Rossi,A., Nicchia,G.P., Svelto,M. and Frigeri,A.
  TITLE     Translational regulation mechanisms of aquaporin-4 supramolecular
            organization in astrocytes
  JOURNAL   Glia 59 (12), 1923-1932 (2011)
   PUBMED   21850708
  REMARK    GeneRIF: When transfected in Hela cells, the longer rat AQP4
            isoform, not present in humans, impairs formation of the orthogonal
            array of particles in astrocyte primary cultures.
REFERENCE   5  (bases 1 to 5018)
  AUTHORS   Hirt,B., Gleiser,C., Eckhard,A., Mack,A.F., Muller,M., Wolburg,H.
            and Lowenheim,H.
  TITLE     All functional aquaporin-4 isoforms are expressed in the rat
            cochlea and contribute to the formation of orthogonal arrays of
            particles
  JOURNAL   Neuroscience 189, 79-92 (2011)
   PUBMED   21621589
  REMARK    GeneRIF: Identified all functional AQP4 isoforms -M1, M23, and Mz-
            and the formation of higher-order complexes in the organ of Corti
            of the rat.
REFERENCE   6  (bases 1 to 5018)
  AUTHORS   Moe,S.E., Sorbo,J.G., Sogaard,R., Zeuthen,T., Petter Ottersen,O.
            and Holen,T.
  TITLE     New isoforms of rat Aquaporin-4
  JOURNAL   Genomics 91 (4), 367-377 (2008)
   PUBMED   18255256
  REMARK    GeneRIF: rat AQP4 has six cDNA isoforms, formed by alternative
            splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond
            to the two classical M1 and M23 isoforms, respectively
REFERENCE   7  (bases 1 to 5018)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   8  (bases 1 to 5018)
  AUTHORS   Jung,J.S., Bhat,R.V., Preston,G.M., Guggino,W.B., Baraban,J.M. and
            Agre,P.
  TITLE     Molecular characterization of an aquaporin cDNA from brain:
            candidate osmoreceptor and regulator of water balance
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13052-13056 (1994)
   PUBMED   7528931
REFERENCE   9  (bases 1 to 5018)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 5018)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            On Aug 28, 2014 this sequence version replaced NM_001142366.1.
            
            Summary: This gene encodes a member of the aquaporin family of
            intrinsic membrane proteins that function as water-selective
            channels in the plasma membranes of many cells. This protein is the
            predominant aquaporin found in brain and has an important role in
            brain water homeostasis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene. A
            recent study provided evidence for translational readthrough in
            this gene and expression of an additional C-terminally extended
            isoform via the use of an alternative in-frame translation
            termination codon. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (2, also known as AQP4c) contains
            an alternate 5' terminal exon, which causes translation initiation
            from an in-frame, downstream start codon, compared to variant 1.
            The resulting isoform (M23) has a shorter N-terminus compared to
            isoform M1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.746681.1,
                                           SRR26360176.2309478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000018.1  6797821-6797926     c
            107-521             JAXUCZ010000018.1  6794980-6795394     c
            522-686             JAXUCZ010000018.1  6793452-6793616     c
            687-767             JAXUCZ010000018.1  6792936-6793016     c
            768-5018            JAXUCZ010000018.1  6782389-6786639     c
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..5018
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="aquaporin 4"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
     exon            1..106
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            107..521
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1046
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="isoform M23 is encoded by transcript variant 2;
                     mercurial-insensitive water channel"
                     /codon_start=1
                     /product="aquaporin-4 isoform M23"
                     /protein_id="NP_001135838.1"
                     /db_xref="GeneID:25293"
                     /db_xref="RGD:2143"
                     /translation="MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPL
                     PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCL
                     GAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR
                     TDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
                     AVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGV
                     VHVIDIDRGDEKKGKDSSGEVLSSV"
     misc_feature    165..818
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    165..818
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Major intrinsic protein; Region: MIP; pfam00230"
                     /db_xref="CDD:395174"
     misc_feature    order(303..305,357..365,699..704,711..713,720..722)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(303..305,357..365,699..704,711..713,720..722)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(363..371,711..719)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(363..371,711..719)
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     exon            522..686
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..767
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
     exon            768..5018
                     /gene="Aqp4"
                     /gene_synonym="AQP-4; Miwc; WCH4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct cggtcccctc ctcttttttt cctatcaaac cccagaagac agcacctgtg
       61 atagcacctt gcccctctgc cacctggcta caaccctgga cagctgtaag tgtggacctc
      121 cctgcagcag agagagcatc atggtggctt tcaaaggcgt ctggactcaa gccttctgga
      181 aggcggtcac agcagagttc ctggccatgc tcatctttgt tctgctcagc gtgggatcca
      241 ccattaactg gggtggctca gagaaccccc tacctgtgga catggtcctc atctccctct
      301 gctttggact cagcattgcc accatggttc agtgcttcgg ccacatcagc ggtggccaca
      361 tcaacccagc ggtgacagtg gccatggtgt gcacacgaaa gatcagcatc gccaagtccg
      421 tcttctacat cactgcgcag tgcctggggg ccatcatcgg agctgggatc ctctacctgg
      481 tcacaccccc cagcgtggtg ggaggattgg gagtcaccac ggttcatgga aacctcactg
      541 ctggccatgg gctcctggtg gagctaataa tcactttcca gctggtattc accatttttg
      601 ccagctgtga ttccaaacgg actgatgtta ctggttccgt tgctttagca attgggtttt
      661 ccgttgcaat tggacatttg tttgcaatca attataccgg agccagcatg aatccagctc
      721 gatcctttgg ccctgcagtt atcatgggaa actgggaaaa ccactggata tattgggttg
      781 gaccaatcat aggcgctgtg ctggcaggtg cactttacga gtatgtcttc tgtcctgacg
      841 tggagctcaa acgtcgccta aaggaagcct tcagcaaagc tgcacagcag acgaaaggga
      901 gctacatgga ggtggaggac aaccggagcc aagtggagac agaagacttg atcctgaagc
      961 ccggggtggt gcatgtgatc gacattgacc gtggagacga gaagaagggg aaggactcgt
     1021 ctggagaggt attatcttct gtatgactag aggacagcac tgaaaacaga agagactccc
     1081 tagaactggc ctcagatttc ctgccaccca ttaaggaaac agatttgtta taaattagac
     1141 atatgcgggt ttcttgtttc acatcttgtt acacagctta aataacacat attttactat
     1201 tatcaatggg ggggagaagc ctataattaa tatgacattt taatggaaat cttttttaat
     1261 gtatcctcga agcaaatatt cagctactgt attgactttc cttttgttag taataactga
     1321 aactatgagc cgaaatctga tcaagtctta cttaacagag cattggacat ctctgtgagg
     1381 aagcttgtac tgcccatcct cacttcaaaa ctgacaccat tagattgatt taaaaatgac
     1441 aaaatgcagc acatcaccga atcatgtgcg ttttaggaga agaaatgtag taagttcttc
     1501 cacaagctat cccttactta ttaactacct tggaggagtt aaaaatagca cttgccattg
     1561 ctaatatatc atgcgtattt atatagctga ctgtcagatc ccaaccccaa ttcactataa
     1621 tccttcttcc ccctcagcat ccaagaaacc atagaactaa aagtcaaaag aaatggaaag
     1681 aatattaact tctgtccatg tgttggtttc atctaatgaa acctgtacat gggacaccca
     1741 cccactgagg ttcaggacag ccagacctgg ggagtctggt gggaggtgga gcaaaggttg
     1801 ctacttacag tcctacaacc atcacaagag gggcaacctc tgttatgaaa tgattgctct
     1861 gttttcagtg cacactctta aggataccac aaaagattaa ctgcctaagc ctttaactac
     1921 ttcacttgct tttaaagctt atttgcaaaa ttggggaatt tgtttgccat ttgggcacct
     1981 atactgaaac actagctgag atattttaga tgacaacttg actagttgag tcctgccttt
     2041 ctgttggtgt ctaaatcctg cttactctag gtggtataaa ccagtcctgc cccgtgccaa
     2101 ctgctaatgc ttcccatgac atctgttgat ggtcagcatt gtgagtgtaa taatacccat
     2161 tggtgtggat taaaatatat ggcagataag gtgcaaggta gctgccaata aaggtgtgag
     2221 cagacagcct ctgtgcaaag ctcctaggtg ccccatcagc acagagtgta cgtgctttta
     2281 aggtatttac ctcctgcctg atttatttgt tagaaccatt tgtttttccc atactgcttt
     2341 gccttccgcc cgtcgaatgc tctgtggaaa ccccagtttc tacactcata gcagtctagc
     2401 ctaacattta ttttagacaa agtgctgtaa acgtcaattt caccaaacaa aagtcagtag
     2461 tgggagagag aagagccacc tcttcaagga ctaacttgta aatagctgat catcagggct
     2521 ttcttctccc aagcacaatt ccagctgcgt gtgacttctt attgttaatg gcagttttgt
     2581 gtctgtggca gcaagataat ggaccactat taaagttgat tctcttcggt gctaggaaac
     2641 tgatatgcaa gttcccagac agccacgagg acagcatatg cctctcagag ccacgggcgt
     2701 attctgaggt agatgctggg agcataggcc tcatttcagg gctttgaatg tactacacca
     2761 gagacataag cttcctctct gatcagaacc tacagaacca aggcgtagac cggtgttttc
     2821 acaatatacc acatgggctt aagatcaggg tgctccagtc ggaaggtgat aaccttcaac
     2881 aaacatgttg ggttaaaacc aaattagggg tcgggtcaaa aataaattca gttaaccagg
     2941 aatagtgggg cacatttctg attacttttt caaaatcctg gcctgtgatt atttttatta
     3001 tgctacacag cttgcattgt gtgctcactt tctcagtcat ttccagggac agcatccaat
     3061 atggtaggaa ctgaaaagca gtgaagtgga gatgcatttt ctagcagtgg cagagtgctg
     3121 ggcacacagt aggtaatcac agcaagcatg ctgtttgaat gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt gtgtgtgtac atatatatgg ctctcatttg ggatttaaga
     3241 acaataacct cttctaattt ttgctttgct caatctttag tggaagcgtg attttgagtg
     3301 ttatcaaagg aaggtcatgt gggtgtggaa acaaagagca tgttttcaca ttctactgtt
     3361 taagggcaga gagtgacggc ctcgtcactc ttcgtcttgc atttcactca cggctctgcc
     3421 agtgaaacag taatgaaatt gtccctttct aatgacatct atgcagcagg ggtctattgc
     3481 cttgtgggtg acaccaaatt atcctacata ttaggagatc agggcttttc ctttaatccc
     3541 ttcttattaa ggagtgcata gtgccgtacc caagagacag ctactggcag atacagagca
     3601 gagagatcag agaggaaaaa tcaggaaggc ataaaagatt tatacgagcc atggaacaac
     3661 gccaactgtc tgttccctca ggaggagaac agagtcaccc cccaagtttc gaggtggtcc
     3721 atacactgga aaagtacaca ttctgtcaaa acacagcaga aaggaatctt ttttttaaga
     3781 ttttgaggat tttttttcaa atgtaggact ctgacttcta aatgtgtgtt tccattttct
     3841 tccaaatgtt ctaccctttc acactataag aaaatgtttt ctgtagccta agtcactggt
     3901 aattttacaa cttgtttctg tgctttgaca ctactcataa attctctccc tttcgatcat
     3961 cagagaagtg tccttccaca tctcagagac actgctggcc agagctgctc cctgatgaag
     4021 atttcataag gagattagaa atctctggaa agcatgcatg ttagaaatga gctgatttct
     4081 tagaggtcaa tttcaaaagc gcaacacttc taggaggacc caggcaatgt gtgcactgct
     4141 ctaaccccac tgatggcagt gaaatctcaa aaccggggaa ctaattaaaa tgatggcatg
     4201 agaccttgcc tggccctttg ttgtgtgacg ttgacacctt cctcccacat cagaaatctg
     4261 acagagacat gacctctctg acaattgaag acagagagcc aaatagacaa tcttataaaa
     4321 ctatgagagg ttcttatcat taaaccacag gatatatgaa tgtggactct tggacctgaa
     4381 agtcattacg tctttctcca gtgaactcat gggataaaat cttaggaaag catggtttct
     4441 ctttgaaagt gtactataac aactcacttc ctttacgtca gctttttgag ctcatgtctg
     4501 ggtgttactg cttttcagaa caccttaaac aacacaaacc tttcaaaccc ataactctca
     4561 gaaagaaatg ttaggcactt aacttcaaaa ctcaaaaact gtgaatactc acttttggca
     4621 cataacttcc ctgaaaacac tcacccaaca aatgatacaa cgcataccat gaacactaga
     4681 tttaagagca gttatagtgt tactgtttta agtcaaaatt caagagctaa aaaatatacc
     4741 taacatatat attccattga aatgtattcc tagactgttc tcatgtttga tcaaataaac
     4801 agcaatttat ggaaatatgt aaacaattat ttatcatttt atcacccaga tcacgataaa
     4861 cctgcaactt atgaggaact aagaaaaata aaatgaatgc ctggttatat ttacaattat
     4921 ttattaactt aatattattg caaaattaga gttaatgtta aatggattta aactgtaatg
     4981 actaatattt ggaaaatcta ataaaagtgt tagctgtg
//
LOCUS       NM_001304734            1904 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1G2, mRNA.
ACCESSION   NM_001304734
VERSION     NM_001304734.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1904)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1904)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (MOR-1G2) represents use of an
            alternate promoter and 5' UTR, and uses an alternate 3' exon,
            compared to variant MOR-1C2. The resulting isoform (1G2) is shorter
            than isoform 1C2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU024650.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  45565371-45565459
            90-442              JAXUCZ010000001.1  45617450-45617802
            443-963             JAXUCZ010000001.1  45618567-45619087
            964-1904            JAXUCZ010000001.1  45637816-45638756
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1904
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..89
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="upstream in-frame stop codon"
     CDS             70..1002
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="isoform 1G2 is encoded by transcript variant
                     MOR-1G2; mu-type opioid receptor; MUOR1; opioid receptor
                     B; M-OR-1"
                     /codon_start=1
                     /product="mu-type opioid receptor isoform 1G2"
                     /protein_id="NP_001291663.1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
                     /translation="MGSGPMLYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT
                     WPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVC
                     NWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLII
                     TVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALI
                     TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNST
                     RVRQNTREHPSTANTVDRTNHQLENLEAETAPLP"
     misc_feature    91..846
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    91..846
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor subtype mu, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_Mu_opioid_R; cd15090"
                     /db_xref="CDD:320218"
     misc_feature    112..192
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    112..192
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320218"
     misc_feature    order(175..177,184..189,223..240,244..249,256..258,
                     391..393,397..411,490..492,499..507,511..519,523..528,
                     682..684,691..696,700..705,712..714,745..750,754..762,
                     769..771,778..783)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    order(175..177,184..189,223..240,244..249,256..258,
                     391..393,397..411,490..492,499..507,511..519,523..528,
                     682..684,691..696,700..705,712..714,745..750,754..762,
                     769..771,778..783)
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320218"
     misc_feature    223..315
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    223..315
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320218"
     misc_feature    349..417
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    349..417
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320218"
     misc_feature    490..579
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    490..579
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320218"
     misc_feature    622..714
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    622..714
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320218"
     misc_feature    748..825
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     misc_feature    748..825
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320218"
     exon            90..442
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..963
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1904
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggaac accgaaactg ggaagccctc caggctcttt cagagagaat attctacaga
       61 gcttgaagga tgggatctgg tccaatgcta tacaccaaaa tgaagactgc caccaacatc
      121 tacattttca accttgctct ggcagacgcc ttagcgacca gtacactgcc ctttcagagt
      181 gtcaactacc tgatgggaac atggcccttc ggaaccatcc tctgcaagat cgtgatctca
      241 atagattact acaacatgtt caccagcata ttcaccctct gcaccatgag cgtggaccgc
      301 tacattgctg tctgccaccc agtcaaagcc ctggatttcc gtaccccccg aaatgccaaa
      361 atcgtcaacg tctgcaactg gatcctctct tctgccatcg gtctgcctgt aatgttcatg
      421 gcaaccacaa aatacaggca ggggtccata gattgcaccc tcacgttctc ccacccaacc
      481 tggtactggg agaacctgct caaaatctgt gtctttatct tcgctttcat catgccggtc
      541 ctcatcatca ctgtgtgtta cggcctgatg atcttacgac tcaagagcgt tcgcatgcta
      601 tcgggctcca aagaaaagga caggaatctg cgcaggatca cccggatggt gctggtggtc
      661 gtggctgtat ttatcgtctg ctggaccccc atccacatct acgtcatcat caaagcgctg
      721 atcacgattc cagaaaccac atttcagacc gtttcctggc acttctgcat tgctttgggt
      781 tacacgaaca gctgcctgaa tccagttctt tacgccttcc tggatgaaaa cttcaagcga
      841 tgcttcagag agttctgcat cccaacctcg tccacgatcg aacagcaaaa ctccactcga
      901 gtccgtcaga acactaggga acatccctcc acggctaata cagtggatcg aactaaccac
      961 cagctagaaa atctggaggc agaaactgct ccattgccct aactgggtct cacaccatcc
     1021 agaccctcgc taagcttaga ggccgccatc tacgtggaat caggttgctg tcagggtgtg
     1081 tgggaggctc tggtttcctg agaaaccatc tgatcctgca ttcaaagtca ttcctctctg
     1141 gctacttcac tctgcacatg agagatgctc agactgtatc aagtactcag aaagaagaga
     1201 ctaccggaca ctcctgaatc cagctcatgt acagaaccat ctgaaacacc cagtggacca
     1261 caatgctctg tggtatgtga atttcgatca tcatagaagg tgacccctct ctatgtagaa
     1321 tttttatttt tcaagcaaat acttatgacc tcatcaaaga aaataatgtc acttgttaaa
     1381 ttcactgtag tgatacataa agtaaatgct acctctgacc tctgacccag tcaccttctg
     1441 tagagagttc cagtcctttt gtgatggaat acatcatttc caacttaaaa ctttcacctt
     1501 gaagttatgg tctagttaag acatcagggg cacctccgtt tcttggtttt gtattgtttg
     1561 aaagaagacg acatcttcct ccttagctgt gtgttgaaaa tgaaagggat tgaaagcaca
     1621 gtgtcaactg cagaatggtt gattctcact ctgaaaggat ttacttcgag ttataatgtg
     1681 ggggttagga gaggggctgt tttttcctaa ttcccaccat gtcctctaag tgttcacaag
     1741 gtcaagttca gaaggtcacc cagtgagttc atcatgctat cattctgagc aggaagccaa
     1801 gaatttcgct ctcttcattt ttttcagtaa tttctccaca ctgcacgctc ttttgtatta
     1861 ttttccctga tgccttatga aacagcatga tcaaacaaca gatg
//
LOCUS       NR_027877               1560 bp    RNA     linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus opioid receptor, mu 1 (Oprm1), transcript variant
            MOR-1D, non-coding RNA.
ACCESSION   NR_027877 NM_001038598
VERSION     NR_027877.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Bischoff,A.R., Dalle Molle,R., Mucellini,A.B., Pokhvisneva,I.,
            Levitan,R.D., Meaney,M.J. and Silveira,P.P.
  TITLE     Accumbal mu-opioid receptors and salt taste-elicited hedonic
            responses in a rodent model of prenatal adversity, and their
            correlates using human functional genomics
  JOURNAL   Stress 27 (1), 2294954 (2024)
   PUBMED   38140734
  REMARK    GeneRIF: Accumbal mu-opioid receptors and salt taste-elicited
            hedonic responses in a rodent model of prenatal adversity, and
            their correlates using human functional genomics.
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Miyahara,K., Hino,M., Shishido,R., Izumi,R., Nagaoka,A.,
            Hayashi,H., Kakita,A., Yabe,H., Tomita,H. and Kunii,Y.
  TITLE     Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1
            expression in the postmortem brain and responsiveness to
            antipsychotics
  JOURNAL   J Psychiatr Res 166, 10-16 (2023)
   PUBMED   37659266
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Yu,J., Zhang,Y., Xun,Y., Tang,H., Fu,X., Zhang,R., Zhu,F. and
            Zhang,J.
  TITLE     Methylation and expression quantitative trait loci rs1799971 in the
            OPRM1 gene and rs4654327 in the OPRD1 gene are associated with
            opioid use disorder
  JOURNAL   Neurosci Lett 814, 137468 (2023)
   PUBMED   37660978
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Chen,Y., Han,Y., Liu,L., Liu,M., Lin,J., Tang,Y., Guo,S., He,R. and
            Wu,Q.
  TITLE     N6-Methyladenosine methylase METTL3 contributes to neuropathic pain
            by epigenetic silencing of mu opioid receptor
  JOURNAL   Behav Brain Res 452, 114592 (2023)
   PUBMED   37482304
  REMARK    GeneRIF: N[6]-Methyladenosine methylase METTL3 contributes to
            neuropathic pain by epigenetic silencing of mu opioid receptor.
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Kaya-Akyuzlu,D., Ozkan-Kotiloglu,S., Danisman,M., Bal,C., Ogur,B.
            and Ispir,G.Z.
  TITLE     OPRD1 rs569356 polymorphism has an effect on plasma
            norbuprenorphine levels and dose/kg-normalized norbuprenorphine
            values in individuals with opioid use disorder
  JOURNAL   Environ Toxicol Pharmacol 100, 104143 (2023)
   PUBMED   37146669
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Sedqi,M., Roy,S., Ramakrishnan,S., Elde,R. and Loh,H.H.
  TITLE     Complementary DNA cloning of a mu-opioid receptor from rat
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 209 (2), 563-574 (1995)
   PUBMED   7733926
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Zimprich,A., Simon,T. and Hollt,V.
  TITLE     Cloning and expression of an isoform of the rat mu opioid receptor
            (rMOR1B) which differs in agonist induced desensitization from
            rMOR1
  JOURNAL   FEBS Lett 359 (2-3), 142-146 (1995)
   PUBMED   7532594
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Bunzow,J.R., Zhang,G., Bouvier,C., Saez,C., Ronnekleiv,O.K.,
            Kelly,M.J. and Grandy,D.K.
  TITLE     Characterization and distribution of a cloned rat mu-opioid
            receptor
  JOURNAL   J Neurochem 64 (1), 14-24 (1995)
   PUBMED   7798908
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Surratt,C.K., Johnson,P.S., Moriwaki,A., Seidleck,B.K.,
            Blaschak,C.J., Wang,J.B. and Uhl,G.R.
  TITLE     -mu opiate receptor. Charged transmembrane domain amino acids are
            critical for agonist recognition and intrinsic activity
  JOURNAL   J Biol Chem 269 (32), 20548-20553 (1994)
   PUBMED   8051154
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Schroeder,J.E., Fischbach,P.S., Zheng,D. and McCleskey,E.W.
  TITLE     Activation of mu opioid receptors inhibits transient high- and
            low-threshold Ca2+ currents, but spares a sustained current
  JOURNAL   Neuron 6 (1), 13-20 (1991)
   PUBMED   1846076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L13069.1, AY225402.1 and AY309002.1.
            
            On Jun 25, 2009 this sequence version replaced NM_001038598.2.
            
            Transcript Variant: This variant (MOR-1D) uses an alternate 3' exon
            structure, compared to variant MOR-1C2. This variant is represented
            as non-coding because the use of the 5'-most expected translational
            start codon renders the transcript a candidate for
            nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY309002.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               L13069.1           3-171
            170-984             AY225402.1         1-815
            985-1560            AY309002.1         810-1385
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1560
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /note="opioid receptor, mu 1"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     misc_RNA        1..1560
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /product="opioid receptor, mu 1, transcript variant
                     MOR-1D"
                     /db_xref="GeneID:25601"
                     /db_xref="RGD:3234"
     exon            1..491
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..1371
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001038601.2"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            492..844
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1365
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1459
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1560
                     /gene="Oprm1"
                     /gene_synonym="MORA; Oprm; Oprrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggctac aagcagagga gaatatcaga cgctcagacg ttcccttctg cctgccgctc
       61 ttctctggtt ccactagggc tggtccatgt aagaatctga cggagcctag ggcagctgtg
      121 agaggaagag gctggggcgc gtggaacccg aaaagtctga gtgctctcag ttacagccta
      181 cctagtccgc agcaggcctt cagcaccatg gacagcagca ccggcccagg gaacaccagc
      241 gactgctcag accccttagc tcaggcaagt tgctccccag cacctggctc ctggctcaac
      301 ttgtcccacg ttgatggcaa ccagtccgat ccatgcggtc tgaaccgcac cgggcttggc
      361 gggaacgaca gcctgtgccc tcagaccggc agcccttcca tggtcacagc cattaccatc
      421 atggccctct actctatcgt gtgtgtagtg ggcctcttcg gaaacttcct ggtcatgtat
      481 gtgattgtaa gatacaccaa aatgaagact gccaccaaca tctacatttt caaccttgct
      541 ctggcagacg ccttagcgac cagtacactg ccctttcaga gtgtcaacta cctgatggga
      601 acatggccct tcggaaccat cctctgcaag atcgtgatct caatagatta ctacaacatg
      661 ttcaccagca tattcaccct ctgcaccatg agcgtggacc gctacattgc tgtctgccac
      721 ccagtcaaag ccctggattt ccgtaccccc cgaaatgcca aaatcgtcaa cgtctgcaac
      781 tggatcctct cttctgccat cggtctgcct gtaatgttca tggcaaccac aaaatacagg
      841 caggggtcca tagattgcac cctcacgttc tcccacccaa cctggtactg ggagaacctg
      901 ctcaaaatct gtgtctttat cttcgctttc atcatgccgg tcctcatcat cactgtgtgt
      961 tacggcctga tgatcttacg actcaagagc gttcgcatgc tatcgggctc caaagaaaag
     1021 gacaggaatc tgcgcaggat cacccggatg gtgctggtgg tcgtggctgt atttatcgtc
     1081 tgctggaccc ccatccacat ctacgtcatc atcaaagcgc tgatcacgat tccagaaacc
     1141 acatttcaga ccgtttcctg gcacttctgc attgctttgg gttacacgaa cagctgcctg
     1201 aatccagttc tttacgcctt cctggatgaa aacttcaagc gatgcttcag agagttctgc
     1261 atcccaacct cgtccacgat cgaacagcaa aactccactc gagtccgtca gaacactagg
     1321 gaacatccct ccacggctaa tacagtggat cgaactaacc accagaccta gaccctgtgg
     1381 aagaacgtgg tctttgaaat cgcgtgcaga atccaatgtg gagcacttcc attgtggagc
     1441 cgcattaatc tataacaatg aactaaaaat agggccagtg tcctggctcc agatgcctgc
     1501 gcacgtgctc gtgcgcccct ggtaatgaac acgggctccg attctgaata tccttctgtg
//
LOCUS       NM_001436703            1426 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 163 (Ccdc163),
            transcript variant 2, mRNA.
ACCESSION   NM_001436703 XM_063287412
VERSION     NM_001436703.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1426)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287412.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.22610.1,
                                           SRR26643293.29438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000005.1  135409506-135409567
            63-307              JAXUCZ010000005.1  135409771-135410015
            308-341             JAXUCZ010000005.1  135410176-135410209
            342-526             JAXUCZ010000005.1  135411011-135411195
            527-608             JAXUCZ010000005.1  135411301-135411382
            609-792             JAXUCZ010000005.1  135411658-135411841
            793-860             JAXUCZ010000005.1  135412531-135412598
            861-928             JAXUCZ010000005.1  135413270-135413337
            929-1032            JAXUCZ010000005.1  135413635-135413738
            1033-1166           JAXUCZ010000005.1  135414498-135414631
            1167-1426           JAXUCZ010000005.1  135415315-135415574
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1426
                     /gene="Ccdc163"
                     /note="coiled-coil domain containing 163"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
     exon            1..62
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            63..307
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1273
                     /gene="Ccdc163"
                     /note="isoform a is encoded by transcript variant 2;
                     transmembrane protein CCDC163"
                     /codon_start=1
                     /product="transmembrane protein CCDC163 isoform a"
                     /protein_id="NP_001423632.1"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
                     /translation="MSRSSSWSDQLQAVLSSTDENMARIKQSLYPLRVSSTGDLADTW
                     ISPHHLPPQPGAQAQQPWALKTPILGESLSCTEAHSSSLWDEVTKLRSQLQTQTQVTE
                     ALRHSVQSLLKDREQQMFKISALEASLKLLQEGPKGRALLEQRLEGLRKELQGLRSQV
                     QELVQTQMRTRPGKFSTASGFHQELQNEHQLLWEESEILREELKLLRDQLSQHQELLL
                     EQMAEGRQVQARSWKTLEHLQSGQMGKVHTLEVTRTEAHDAQKEEPYLLRSSVHARQS
                     KLPLATIFDMSLSSSSSEVSLPDCDRSWELLKKLDRELQNNSLSNLEPSSSQFHAQDV
                     GQEDLFLHGPRIF"
     misc_feature    <473..>1015
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <473..>1015
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            308..341
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            342..526
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            527..608
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            609..792
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            793..860
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            861..928
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1032
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1166
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1426
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgttgcc tgtggtctct gcaagaagtg gactcagttt cccgggtggc gctgcggcac
       61 cgttctagat tcgcagtatt ggtatcgtac tgtatctgga gccctagtat attcccgctt
      121 tcctcatttc catctaactc tgtggcttgt cctgggctgt tccgcgggta tttcggtctg
      181 ggagagcaag aacaggagaa gtcacggacg caatttcaag tgctccagga tgagcaggag
      241 ctctagctgg tctgatcagc ttcaagcagt tctcagttca actgatgaaa atatggcccg
      301 aattaagcag agtttgtatc ctcttcgagt ttcctctaca ggggacctgg ctgacacctg
      361 gatttcccct catcacttgc ctcctcagcc aggggcccaa gctcaacagc cttgggctct
      421 aaagactccc attcttggtg agagtctgag ctgtactgaa gcccacagct cctctctctg
      481 ggatgaagtt actaaactcc gctcccagct tcagactcag actcaggtga ctgaggcact
      541 aaggcattct gtgcagagcc tgttgaagga tcgggagcag cagatgttca agatcagtgc
      601 tctagaagca tcactaaaac tgctgcagga gggtccaaaa gggagagccc tcctggagca
      661 acgcctggaa ggattgagaa aagaactgca aggccttcgg agtcaggttc aggagctagt
      721 ccaaacccaa atgagaacaa gaccaggaaa gttcagcact gccagtggct ttcaccaaga
      781 gctgcagaac gagcaccaac ttttgtggga agagtcagag attcttcggg aggagctgaa
      841 gttgcttcga gaccagctga gccaacatca ggagttgtta ctggaacaga tggctgaagg
      901 gcgccaggtt caggcccgca gctggaagac gttggaacac ctacagagtg gccagatggg
      961 caaggttcat accttggagg ttaccaggac agaggcccat gatgcccaga aggaagagcc
     1021 ctatctcctc aggagctctg ttcatgcccg gcagtctaag ctgcctctgg ccaccatctt
     1081 cgacatgtct ctttcttcat ctagctctga agtcagtctc ccagactgtg accgtagctg
     1141 ggaactttta aagaaactag atagggaact ccagaacaac tccctttcta acctggaacc
     1201 cagcagctct cagttccatg cccaggatgt tgggcaagaa gacctgttcc ttcatggccc
     1261 cagaatcttc tagagtgacc tgtaagagct tgtgagaaaa tgagatgcag cttctctcca
     1321 aggccgcctt tgcatcccct ctggtacgtg ccctctttac ggaggcatct cactctccag
     1381 ccattcctgc tccccagcta attcaaaata aagtggctta gttctc
//
LOCUS       NM_001436685            2090 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 1, mRNA.
ACCESSION   NM_001436685 XM_006252624
VERSION     NM_001436685.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252624.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.35059.1,
                                           SRR26643298.70568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-351             JAXUCZ010000016.1  7303950-7304056
            352-486             JAXUCZ010000016.1  7305050-7305184
            487-550             JAXUCZ010000016.1  7305489-7305552
            551-657             JAXUCZ010000016.1  7308347-7308453
            658-799             JAXUCZ010000016.1  7309595-7309736
            800-1042            JAXUCZ010000016.1  7324014-7324256
            1043-1151           JAXUCZ010000016.1  7326003-7326111
            1152-2090           JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2090
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            245..351
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    320..322
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            352..486
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1306
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001423614.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFD
                     PQPTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTS
                     ELLFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAET
                     LFYVCGPPPMTDFFSKHLESSHVPKEHICFEKWW"
     misc_feature    575..1294
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    575..1294
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(656..658,692..703,752..760,770..781,902..904)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(656..658,692..703,752..760,770..781,902..904)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(692..694,698..703)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(692..694,698..703)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(770..772,779..781,788..790,809..811)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(770..772,779..781,788..790,809..811)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(887..889,899..910,914..916)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(887..889,899..910,914..916)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(902..907,1010..1018,1217..1222)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(902..907,1010..1018,1217..1222)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     exon            487..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..657
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            658..799
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1042
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1151
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..2090
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcaggaactt tgtgggaact tctctgtgtt ctggctggtg cgaatctaga ggtctcagta
      301 cagcactgtg tcagccagct gaggactccc agaaccttat gggtttctaa attccatttg
      361 cccaggcagc accatggccc atgtcttgat tcctgggttg tctcgaggct ctgtgggagc
      421 catctgcact caggctgctt cgtgggcact gcctaccagc actctgcgtt cccttacctt
      481 agccagcgta atgagatcca gaaggaaaac tgaccaccta gagagaaccg ccactgtcct
      541 ccgccgggag gtcatggctg cagctaaggt gtgtgagatc actcacgagt ctccatcagt
      601 gaagagcctc cgtttgcttg ttgctgataa agacttttcc ttcaaggctg gccagtgggt
      661 tgatttcttc atcccaggag tttcagtggt tggtgggttt tcaatttgct ccagtcccca
      721 acagctagaa cgagagagaa taatagaatt ggcagtgaaa tacacgaacc atcctcctgc
      781 tgtctgggtt cacaataagt gcacacttga ctcagaagtg gctctcagag taggtggaga
      841 gttcttcttt gaccctcagc ccacagatgc ccctcgaaac ctcgtcttga ttgctggagg
      901 ggttgggatt aaccccctgc tttctatcct gcgccactcg gcagatctcc accgggacca
      961 caaagaaaaa aggagaggct atgatatagg aacaataaaa ctgttctaca gcgcaaagaa
     1021 caccagtgaa ctcctgttta agaaaaatat cctcgactta gtacatgagt ttcctgagaa
     1081 gattgcctgc agttttcacg ttacaaaaca gacgacccaa atcagttctg aacttaagcc
     1141 ttatgtcaca gatggaagaa taacagagaa ggagataaga gagcacattt cggcagagac
     1201 tctgttctat gtctgcggcc cacctccaat gacagacttt ttctctaagc atctggaaag
     1261 cagccacgtt cccaaggaac acatctgctt tgagaagtgg tggtaggagc aggcacagaa
     1321 gacctgagag ccgctcagga cagtgagaac cagcaacaga gtcacacgag aaacttcccg
     1381 cagacttcat tggtggcact atttttcact atattgattt ttctttcatt aattatccta
     1441 tgatagttca ttattacaga atttctgacc tttggggaaa agaccatgct caacccaatt
     1501 gtaattaaaa gatttactga tgagctgctg gcaggaagac aggctgagag ccagatttga
     1561 gatggccata aataaaagag ggtgggggga aaggtttccc aaagggaaaa ccatggggag
     1621 gctcacggta tctatgcaag caggcagact ctggcctgtt ctgccaagat taagtgggta
     1681 aagcaactgg aaacaatctg ggtgtctgca cacgcaagtt acagaagctg aaaacggcct
     1741 ccatagccag gagaagctca cagctgtgcg tttctgggga cccctgagcc agggctgttt
     1801 tctgggaccc cgtctttctg gaattttgag tctatggcga gcagtcatca gtactaagat
     1861 ggagggaggc ctagaaaaaa atagtttctc gagttggcct ttacaccacg aactgattaa
     1921 tacaggtttt tcttttgccc tttgggggca aattagtcta attatgttaa ttaaaggaaa
     1981 gtgtgggttt tgtgtgaact gtatacttct ctaaataatt ggacagaaat tcataaaatt
     2041 tatgtttact gaatttataa ttttaaatac attctttatt ttgaaatgtc
//
LOCUS       NM_001436693            2722 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 9, mRNA.
ACCESSION   NM_001436693
VERSION     NM_001436693.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM085077.1, SRR26360172.2954389.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-550             JAXUCZ010000016.1  7308347-7308453
            551-2722            JAXUCZ010000016.1  7309595-7311766
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2722
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..833
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 5 is encoded by transcript variant 9;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 5"
                     /protein_id="NP_001423622.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKVSNHLKHNFLVCVSTVPA
                     CLFVHHMRVSFPQRWSDSLELEPLMVVS"
     misc_feature    468..>689
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    468..>689
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..2722
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gaggtcatgg ctgcagctaa ggtgtgtgag atcactcacg
      481 agtctccatc agtgaagagc ctccgtttgc ttgttgctga taaagacttt tccttcaagg
      541 ctggccagtg ggttgatttc ttcatcccag gagtttcagt ggttggtggg ttttcaattt
      601 gctccagtcc ccaacagcta gaacgagaga gaataataga attggcagtg aaatacacga
      661 accatcctcc tgctgtctgg gttcacaata aggtgagcaa ccaccttaaa cataactttt
      721 tagtgtgtgt gagtactgta cctgcatgtt tgtttgtgca ccatatgcgc gtctctttcc
      781 ctcagagatg gtcagattcc ctggaattgg agcctctgat ggttgtgagt tagcactcgg
      841 gtgtccggga ctagacctga gtcctctaag agggacaagt gctctgaact acggagccat
      901 ctctctagac cctcaactga ctgttaaatg tggaggtctg agcacctctg cctctcacta
      961 agtttgtgtt ctgctcagtg ggttcacctg taacctgaac ctgaggaaca agggtcctga
     1021 gtggcgggtg tcgagtggga ggaccaggga tgagaaataa acttaggcca aggtctgctg
     1081 tcgagtctgt taggtacagc actgtctata ctgattgaaa gggggaaatg ccccaggtca
     1141 gcatcgagct aagccggaca ctgttggcaa aaaggacacc ggatacctca tacacagctg
     1201 cctgaggact gacaaccaca gcccaggggg aagagtcagg ttacagaaac cacaaccttg
     1261 cctcctccca ggcactggct ccaacctcag gcaggcccta gcaaattcat tcctgtacaa
     1321 ggacacagag ttaagttccc tttgtccttt catcagggcc tctgagaacg gcttgggtca
     1381 gtctggtccc agtacttggc atgggatgca cagggtgaaa actcacactg agctccccag
     1441 gaaaggtggg gacgcagaac cttgttgggg aactgatttt aaaggattgg taaaagtttt
     1501 acctagcatt ctatatgtgc tgaaaatgac ctttgttaag taaataatct ttctgtggcc
     1561 atcctaaagt aaggaacccc ggctgttaca gacagtagag ctgagtctgt ggtgctccct
     1621 ctgctatgcc ggcctcttca cagccggttc tgagaaggtc cagatctcac ccttgcttat
     1681 acacggtgct gtatcccgag gcttaccctt gaccctgcac acagtgccct ccatacctgt
     1741 tagaacacca gggacaaagt gaacttcaca tttgaccttc tttctttctg tccccccttg
     1801 ttccttaccc tagatagcgt ggcttatgtg tacatataac ctccatccta tttcagccct
     1861 tgatcatctc tgtaaccaaa gtgtgcccag aaatgcagct ctgtctcact cccccagccc
     1921 ccaggaggta ttgacagtca acaaaaagag aacagaaaac aaaaactaac tttattctca
     1981 tcggcgtgtt ttgagaggtt gcagagaatt cttgcttgtg tgggaacttc gtgtaaggag
     2041 aggaaggaag ccaacaggag cagatgttac cggagcagca ggacagatgc gtgctggggg
     2101 acgtggagca tcgttcagca gagcagctgg gagagcaggt tgagtgtact ggctgcagtt
     2161 cagcttagtg aggagaagag ctacccagag aatcagaaac aagccatatt tgtagcaagt
     2221 aacatgccct tgttttgggc actgaaactt gcaaactagg tcactctctt gatccatcct
     2281 ccagtaagaa tcatcaaaaa aaaaaaaaaa gttgtaaaat tataaaagtt cttttaccct
     2341 gaactagctc tggcaccgca gcgccccaag atatctgatt ctccatctca gtcagcagag
     2401 actctcacct gtttgctcca tctcgtatca cacgccgatg gcttctctct gagcccggca
     2461 acaatctctc cacccatcta gttcaccctt tttgtctaat taaaaaaaac ttttctctca
     2521 gatataagct gagcacaact attatcattt tgtaattaaa agaataaaat atatctaaca
     2581 cctagtccaa cattttatca gttaagcaga acatttagtt atccattcca gcttaaggaa
     2641 ggcttaaaat ctgtattata tcttggctag cttgtatact atctgataag tatccaataa
     2701 aatatgtatt ttcagagtta aa
//
LOCUS       NM_001436679            3764 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 268 (Tmem268), transcript
            variant 4, mRNA.
ACCESSION   NM_001436679 XM_017593252
VERSION     NM_001436679.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_017593252.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2276865.1,
                                           SRR22582416.578538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000005.1  81991410-81991562
            154-262             JAXUCZ010000005.1  81993536-81993644
            263-452             JAXUCZ010000005.1  81995120-81995309
            453-562             JAXUCZ010000005.1  81998175-81998284
            563-670             JAXUCZ010000005.1  82002470-82002577
            671-820             JAXUCZ010000005.1  82003984-82004133
            821-931             JAXUCZ010000005.1  82008206-82008316
            932-1012            JAXUCZ010000005.1  82010409-82010489
            1013-1192           JAXUCZ010000005.1  82010883-82011062
            1193-3764           JAXUCZ010000005.1  82014399-82016970
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3764
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
     exon            1..153
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            154..262
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            263..452
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    317..319
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="upstream in-frame stop codon"
     CDS             344..1372
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001423608.1"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
                     /translation="MACEPPSDPGGAAGPLPTSTLGCSTLPQGNPPGWGEELHNGQVL
                     SVLRIDNTCAPISFDLRVAEEQLQAWGIQVPAEQYRSLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAVSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVERPEDLEDSPLLPRTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSQLPQPMGTRHMDSARIPCPCQLIEVHILGT
                     GCCPFLAR"
     misc_feature    458..1327
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     misc_feature    458..1327
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     exon            453..562
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            563..670
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            671..820
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            821..931
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1012
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1192
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..3764
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgtcc ctccgctaag gctcgggtga tcttttcccg ccccacgcgt caggcgtggg
       61 atctgcaggg cagggcgggt gatttctggg gtgaaggaac cctaaggcca gagggcagag
      121 acccgggagc cagctgccta aggccgaggc caggaatccc cacactccca ctttgcaggt
      181 catcccagcc tcgtgtaact gctcctgttg aagccttgag ctacacagcg aagaggccag
      241 aaggctcagt gcctccctga aggcaagtgg aggtgagacg ctgcccggtg tgaactgcac
      301 ccctagaaac aggaagtaga agctagaccg ctgtctgtct gccatggctt gtgaacctcc
      361 ctcagatcct ggtggggcag ctggtcctct gcccacctcc accctgggct gcagcaccct
      421 gcctcagggg aaccctcctg gctgggggga agagctacac aatggccagg tcctctcagt
      481 cctccggatc gacaacacct gtgcacccat ctcctttgac ctgagagttg cagaagaaca
      541 gctgcaggcc tggggcattc aggtccctgc tgagcagtat aggagcttgg ctgagagtgc
      601 gcttttggag cctcaagtga ggaggtacat catctacaac tccaggccca tgaggctggc
      661 ctttgctgtg gtgttctatg tgttggtgtg ggccaacatc tactccacca gccaaatgtt
      721 tgccctaggc aaccagtggg caggtgtgct gcttgcgacc ctggccgctg tcagcctgac
      781 cctgactctt gtgctggtct ttgagaggca gcagaggaag gctaacacta acacagacct
      841 gaggctggtg gctgccaatg gagcccttct gagacaccga gtgctgctgg gggtgacaga
      901 taccgtggag ggatgccaga gtgtgataca gctctggttt gtctactttg acctggagaa
      961 ctgtgtgcag ttcttgtccg atcatgtcca agaaatgaag aggagtcagg agtccttgct
     1021 gagaagcaga ttaagccagc tatgtgttgt catggagact ggagtgagcc ccgtggtgga
     1081 aaggcctgag gacttggaag attctcccct cctgcccaga actcctggtc ctcaggagag
     1141 accactcaca cagactgaac tctatcagct tgttccagag gctgagccag aggagatggc
     1201 ccggcaactg ctggcagtgt ttggtggcta ctacacccgg ctcctggtga cctctcagct
     1261 ccctcagcca atgggaacac gacacatgga ctctgcaagg atcccatgcc cctgccagct
     1321 catagaagta cacattttgg gcacaggatg ttgcccattc ctggccaggt gacctaggga
     1381 tgaaggtgtt catcttcctc caagactaag aagtagggga ggagtcagga gcccagcatg
     1441 gccaccagtg agctcagatg aggtcagcgt ttggagacac tttctcaagt gtcagtcatg
     1501 taggcctttg ggtcatcaag tgcacaccag atgtcttctt ggcatcatac tctgtcctgg
     1561 ccttgctgaa tctggtggct gagctggtgg ctggccttgc agcctggatg gaggatactg
     1621 tctgttgcct gtcaaggcct agggacctgc agctgactcc acagggcaag tgcctgaccc
     1681 tggggtcaga aagtgagacc aaggctccaa ggagacgccc atctttcagc ggtgcctcag
     1741 tctgccggtc acaacctacc tgccctcaat gtgagggaag attcttggaa gggtgagcta
     1801 gcttgtgagt gacagtaccg tctgggattg ttgtctgtta gcaccaaggt tagagagggc
     1861 tagggttgga ggatgggtga ggagacaaaa gcctggcaga tgaccatcaa caaggggcac
     1921 tggaaaagaa gctcctgtta tactcagtga ctttgcactg gcttgctgct tgtgaatgtg
     1981 tttctcttct gccaagcagc agtggtgttt tctgacacta acattgttct ggaatgaggt
     2041 atgattagac actctgggtt tatgtgaaga actcagcgac tttcccaaag ttggaagact
     2101 gtctacagcc ctatgcccag agccctggac tcgtgtaaag gtcctgctcc atgaaccagc
     2161 ctttgtggtt tttgtcctcc acaaatcatc attataagtt ggaactcttc ctggaactgg
     2221 ctggcatatg cattcattcc tgttggactc ttattcatcc ttcaaaaccc tacttttcat
     2281 atccttcctg ctgctttctg tctcactgaa attctgatgg aactgccccc cttatggatg
     2341 ttttatgtta ttcagtgttt ctcctgtaca tacctctttt tctatcaaga ctgtaaactc
     2401 ctcaaggtcc aacactgcac ccaccttcct tttgggaatg acttggactt gtttagaaaa
     2461 aaaaaacaat tttgaaaagt cccatggatt ggtcgccttg ccctctccac ccattgtggc
     2521 aaatgcttct ggaagacatg gttgaatggt aaggcccagg tcgtgatgga ccagaggtct
     2581 ggtctgcagc tgtgtcactc tatttgtgca ccctctgttt gcccatctct acagctggat
     2641 gattttggtg atttccagct tgtgctgttt gttattctta cctccgtgca caaagtgctc
     2701 tcctgccccc aaactgaggg gtccttggtg gggactgacc taaaatagta acctggattc
     2761 ttgttgcaca cctgccacat ccagggctgc gtgaccatgg ctgagtgcac tgcttctctg
     2821 tgtgtccaat gattccttta tagattgatg cagtgaacca cagtggcaca gctcaggaga
     2881 ttttctgggt gagacatgcc ctacttcctt gcattctttg tgtccaagat ggaggagtcc
     2941 cccagccatg tgtcatggca gctttgctca gtgcagttat tcactgtctt ttgagccaca
     3001 gaaaatgtca ctgtgaagtt gatcaaggga agcctgtgct tgtcctctgt tcacagactc
     3061 ttgagcatga tggtggaaac taaaactgtt tggtgagtga gagagttgct catggaggct
     3121 tggtatggtc cttccacagt tttcctgcct gccggatggg acttatgggg tgagcccaca
     3181 gtagaccttc tttgtgtgtg cctcggtttc ctcatttgta aaatccacgt gtctcacctg
     3241 cttcacaaag tcgtcatgag gatgagccat ccagcctttt tttttttttt ttttttgaaa
     3301 aaatatcttt aatcctatcc ctgtgcaggt gaggtctggg agttaaactg aggtcctcag
     3361 taagagtggt ttatgccctt acttcagcac catctctaca gccgagtgct cctaagtctt
     3421 aaggctcaat acccataaga ggcaggaacc atggacaaac cgccatgcag gtaggaacag
     3481 tcaaagccaa gtcctgcctg ccatcttgtc tctgtccctt cagacaccgg ggaggaaagc
     3541 acatcctcca gatgtttcaa cctgaatagc aacaaccttc agtgcttgca acaccaaagc
     3601 tgtcacaaag ccggagcagg aactccataa cctgtcgcca tttctcattt attcttgttg
     3661 tctggtatac agtaggtgct catatgtgtt tgactcttgc ctcatgctca attattccag
     3721 tacctcaggg ttatgtatgc aaataaagat ttatcaaatc tcaa
//
LOCUS       NM_001025656            1629 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 163 (Ccdc163),
            transcript variant 1, mRNA.
ACCESSION   NM_001025656 XM_216494
VERSION     NM_001025656.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001025656.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098949.1, SRR26643429.20484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               JAXUCZ010000005.1  135409506-135410015
            511-544             JAXUCZ010000005.1  135410176-135410209
            545-729             JAXUCZ010000005.1  135411011-135411195
            730-811             JAXUCZ010000005.1  135411301-135411382
            812-995             JAXUCZ010000005.1  135411658-135411841
            996-1063            JAXUCZ010000005.1  135412531-135412598
            1064-1131           JAXUCZ010000005.1  135413270-135413337
            1132-1235           JAXUCZ010000005.1  135413635-135413738
            1236-1369           JAXUCZ010000005.1  135414498-135414631
            1370-1629           JAXUCZ010000005.1  135415315-135415574
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1629
                     /gene="Ccdc163"
                     /note="coiled-coil domain containing 163"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
     exon            1..510
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="Ccdc163"
                     /note="upstream in-frame stop codon"
     CDS             433..1476
                     /gene="Ccdc163"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane protein CCDC163"
                     /codon_start=1
                     /product="transmembrane protein CCDC163 isoform a"
                     /protein_id="NP_001020827.1"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
                     /translation="MSRSSSWSDQLQAVLSSTDENMARIKQSLYPLRVSSTGDLADTW
                     ISPHHLPPQPGAQAQQPWALKTPILGESLSCTEAHSSSLWDEVTKLRSQLQTQTQVTE
                     ALRHSVQSLLKDREQQMFKISALEASLKLLQEGPKGRALLEQRLEGLRKELQGLRSQV
                     QELVQTQMRTRPGKFSTASGFHQELQNEHQLLWEESEILREELKLLRDQLSQHQELLL
                     EQMAEGRQVQARSWKTLEHLQSGQMGKVHTLEVTRTEAHDAQKEEPYLLRSSVHARQS
                     KLPLATIFDMSLSSSSSEVSLPDCDRSWELLKKLDRELQNNSLSNLEPSSSQFHAQDV
                     GQEDLFLHGPRIF"
     misc_feature    <676..>1218
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <676..>1218
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            511..544
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            545..729
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            730..811
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            812..995
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1063
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1131
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1235
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1369
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1629
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgttgcc tgtggtctct gcaagaagtg gactcagttt cccgggtggc gctgcggcac
       61 cggttcgtaa atctcattct ccgcctacca gagtttgaac tcttgagcgg cacttgtcac
      121 tgatttagtg gtgataccgt ccttgatttg tggatgtctc aaccaaaatt cggttcattc
      181 tacactctgt atctgtgtat aatctaggtt tgttgttttg ttgttcttgt tgttttatct
      241 gctttccaag tactccgttc cgtagttcta gattcgcagt attggtatcg tactgtatct
      301 ggagccctag tatattcccg ctttcctcat ttccatctaa ctctgtggct tgtcctgggc
      361 tgttccgcgg gtatttcggt ctgggagagc aagaacagga gaagtcacgg acgcaatttc
      421 aagtgctcca ggatgagcag gagctctagc tggtctgatc agcttcaagc agttctcagt
      481 tcaactgatg aaaatatggc ccgaattaag cagagtttgt atcctcttcg agtttcctct
      541 acaggggacc tggctgacac ctggatttcc cctcatcact tgcctcctca gccaggggcc
      601 caagctcaac agccttgggc tctaaagact cccattcttg gtgagagtct gagctgtact
      661 gaagcccaca gctcctctct ctgggatgaa gttactaaac tccgctccca gcttcagact
      721 cagactcagg tgactgaggc actaaggcat tctgtgcaga gcctgttgaa ggatcgggag
      781 cagcagatgt tcaagatcag tgctctagaa gcatcactaa aactgctgca ggagggtcca
      841 aaagggagag ccctcctgga gcaacgcctg gaaggattga gaaaagaact gcaaggcctt
      901 cggagtcagg ttcaggagct agtccaaacc caaatgagaa caagaccagg aaagttcagc
      961 actgccagtg gctttcacca agagctgcag aacgagcacc aacttttgtg ggaagagtca
     1021 gagattcttc gggaggagct gaagttgctt cgagaccagc tgagccaaca tcaggagttg
     1081 ttactggaac agatggctga agggcgccag gttcaggccc gcagctggaa gacgttggaa
     1141 cacctacaga gtggccagat gggcaaggtt cataccttgg aggttaccag gacagaggcc
     1201 catgatgccc agaaggaaga gccctatctc ctcaggagct ctgttcatgc ccggcagtct
     1261 aagctgcctc tggccaccat cttcgacatg tctctttctt catctagctc tgaagtcagt
     1321 ctcccagact gtgaccgtag ctgggaactt ttaaagaaac tagataggga actccagaac
     1381 aactcccttt ctaacctgga acccagcagc tctcagttcc atgcccagga tgttgggcaa
     1441 gaagacctgt tccttcatgg ccccagaatc ttctagagtg acctgtaaga gcttgtgaga
     1501 aaatgagatg cagcttctct ccaaggccgc ctttgcatcc cctctggtac gtgccctctt
     1561 tacggaggca tctcactctc cagccattcc tgctccccag ctaattcaaa ataaagtggc
     1621 ttagttctc
//
LOCUS       NM_001436720            2287 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1-like (Mtfr1l),
            transcript variant 7, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001436720 XM_039109639
VERSION     NM_001436720.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_039109639.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2729709.1,
                                           SRR26643429.21257.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  152030424-152030475 c
            53-178              JAXUCZ010000005.1  152027744-152027869 c
            179-283             JAXUCZ010000005.1  152027268-152027372 c
            284-393             JAXUCZ010000005.1  152025746-152025855 c
            394-605             JAXUCZ010000005.1  152025303-152025514 c
            606-891             JAXUCZ010000005.1  152024076-152024361 c
            892-2287            JAXUCZ010000005.1  152020175-152021570 c
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2287
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="mitochondrial fission regulator 1-like"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
     exon            1..52
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            53..178
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    89..91
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="upstream in-frame stop codon"
     CDS             164..997
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="isoform b is encoded by transcript variant 7;
                     protein FAM54B; family with sequence similarity 54, member
                     B"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1-like isoform
                     b"
                     /protein_id="NP_001423649.1"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
                     /translation="MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPN
                     ISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVP
                     NLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAGSSNVSSPLPCFG
                     SSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTTCSSSEEDDCISL
                     SKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKG
                     N"
     misc_feature    182..877
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    182..877
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     exon            179..283
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            284..393
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            394..605
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            606..891
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            892..2287
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgagg acgtttgagg cttggccgcc cactgtggta ggaggggctg aggaaaggaa
       61 gtctcatgct ccgggaaatg gcctgatatg aaggagtcac acctccagcc ttccctgtgg
      121 gtgccttgtc ctttgggtgc aggagctggc tgaaacatca ggaatggaag ccaatgtgac
      181 tatcccaatc tggcagaaca agccacatgg ggctgctcgc agtgtggtaa gaagaattgg
      241 gaccaatctg cccctgaaac cttgtccacg ggcatccttt gagaccctgc ccaacatctc
      301 tgacctgtgt ttgaaagatg tgcctccagt cccgactctg gctgacatcg cctggattgc
      361 cgcagatgaa gaggagacat atgctcgggt caggagcgat acacgccctc tgagacatac
      421 ctggaagccc agccctctga ttgtcatgca acggaatgcc tcagtgccca atctgcgtgg
      481 gtctgaggag aggctcctgg ccctgaagaa gccagccctg cctgccctaa gccgcaccac
      541 tgagctgcag gatgaactaa gccacctgcg cagccagatt gctaaaatag tggcagcaga
      601 tgcaggaagt tcaaatgtct cctctccttt gccttgcttt ggatcctcat tccactctac
      661 aacttccttt gtcattagtg acatcactga ggagactgag gttgaggtcc ccgagcttcc
      721 aacaatcccc ctgctttgtt ctgccagccc tgaatgttgc aaatcagaac acaaaactac
      781 ctgcagctcg tctgaagagg atgactgcat ctctctgtcc aaggccagca gctttgcaga
      841 catgatgggc atcctgaagg attttcatcg gataaaacag agccaagacc tgagccggag
      901 tttactgaag gaagaagacc ctgctgtcct tatctctgag gtccttagga ggaagtttgc
      961 cctgaaggaa gaagacatca gtagaaaagg aaactgacag cactgactgc aaactcttct
     1021 cttgctcctg aactccttca atagctgcct tcctcactgc agatgtctgt ctcagttgag
     1081 atctgaacag tcttgctgac tagggcttgg gctggaagag aagagctgga ttatttgtta
     1141 cctgcactta aaccctggca gagtctaagg tctatggttt ttggagatgt gacatttgtt
     1201 acaggtaatt gggtagagtg gagtatctct gcttaaggcg tgaagtttgt tttttcttgt
     1261 ctctgaaaaa taagccctct atgaatgact taattaactc actgcattag actccataat
     1321 tggtctcact ggacatgttg tgcacagcag tcactctcgg cagcttccct gcagcaccac
     1381 agggctgagg gggagcggct gttagttcat gctcacagga aggtcttctg ctgcttcatc
     1441 acagacatac accagtgccc acagtcaccc tttccctcta gctgcagagg gcaggccact
     1501 gggccagcca atatctgggc tgctgcaggg aggcctggcc tgttttttct taaacatttt
     1561 ataaaactac aacctgatct accctccagg gcctcattag ttccactgat tgaatttttt
     1621 tttcttccat ggacttacta agtccatctt ggaaggagaa atgtggagac aaaaagagca
     1681 taccatcctt ctaggacagt gactgatctc tctaggttgg gtcaagattt tatttactgc
     1741 atcatgcatg actcaggtgc cctcagggcc cttttctcta tggtatgaat actgtgtgtt
     1801 ttgagttgaa gcattacctg atattaaatg aaggatttgg agaaatggtg tagtttttct
     1861 ttattctgtc tctgaatttt gaccacagtg gcctctggtg aagagagggc tcctgttgat
     1921 tctaaggtat gtgaactttt aaaaaacagg ctcctgactt cctttcttgc cctcaggaca
     1981 gtggtgctca ctgtgaccct ttaatacaag tccttatgct atggtgaccc cctctcccca
     2041 catccataaa attttgttgc tacttcataa ctaaatttgc taccattaag agttgtaata
     2101 tgggctgtat agacggctca gtggttggga gcactgactg ttctttccgg aggttctgag
     2161 ttcaaatccc agcaatgaca tcgtggctca aaaccatctg taatgagatc cgatgccctc
     2221 ttctggtgtg tctgaagaca gctacagtgt acttacatat aataaataaa taaatcttaa
     2281 aaaaaaa
//
LOCUS       NM_001005543            3194 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 2, mRNA.
ACCESSION   NM_001005543 XM_216505
VERSION     NM_001005543.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 3194)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 3194)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 3194)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 3194)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 3194)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 3194)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 3194)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3194)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 3194)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001005543.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081913.1, SRR26643293.29379.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  135319466-135319609 c
            145-242             JAXUCZ010000005.1  135319012-135319109 c
            243-290             JAXUCZ010000005.1  135314949-135314996 c
            291-401             JAXUCZ010000005.1  135311284-135311394 c
            402-482             JAXUCZ010000005.1  135306753-135306833 c
            483-592             JAXUCZ010000005.1  135304577-135304686 c
            593-1573            JAXUCZ010000005.1  135302980-135303960 c
            1574-1653           JAXUCZ010000005.1  135298279-135298358 c
            1654-1739           JAXUCZ010000005.1  135297655-135297740 c
            1740-1813           JAXUCZ010000005.1  135297473-135297546 c
            1814-2002           JAXUCZ010000005.1  135296880-135297068 c
            2003-2169           JAXUCZ010000005.1  135296609-135296775 c
            2170-2226           JAXUCZ010000005.1  135296062-135296118 c
            2227-2304           JAXUCZ010000005.1  135295896-135295973 c
            2305-2433           JAXUCZ010000005.1  135295084-135295212 c
            2434-3194           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3194
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..144
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="Nasp"
                     /note="upstream in-frame stop codon"
     exon            145..242
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2514
                     /gene="Nasp"
                     /note="isoform a is encoded by transcript variant 2;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform a"
                     /protein_id="NP_001005543.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAE
                     GQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIP
                     GLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETS
                     EDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLS
                     GQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSE
                     TKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANE
                     ETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWD
                     MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEA
                     HDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYE
                     KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMI
                     ASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSG
                     NEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     misc_feature    187..189
                     /gene="Nasp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    280..282
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    310..411
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    526..906
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    529..564
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    550..552
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    562..564
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    <571..1701
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <571..1701
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    688..690
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    706..708
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    745..747
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    811..909
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    904..906
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    907..909
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    934..936
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    949..1050
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1039..1041
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    1099..1101
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1144..1146
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1216..1674
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1318..1320
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1339..1341
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1375..1377
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1537..1539
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1552..1683
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    1576..1578
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1585..1587
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1627..1629
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1636..1638
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1678..1749
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1678..1749
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1765..1995
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1765..1995
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1771..1884
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1771..1884
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1771..1872
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    1771..1857
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1771..1857
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1774..1776,1783..1788,1795..1800,1804..1806,
                     1900..1902,1909..1914,1921..1926,1930..1935,1996..1998,
                     2005..2010,2017..2019)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1774..1776,1783..1788,1795..1800,1804..1806,
                     1900..1902,1909..1914,1921..1926,1930..1935,1996..1998,
                     2005..2010,2017..2019)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1870..1986
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1870..1986
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1897..1998
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    2131..2133
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2194..2196
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2236..2511
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2260..2262
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2263..2265
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2293..2313
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    2323..2325
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2380..2382
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2398..2400
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2413..2415
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     exon            243..290
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            291..401
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            402..482
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            483..592
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1573
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1653
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1739
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1813
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2002
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2169
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2226
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2304
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2433
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3194
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagactgaga gggcataggg aagacctgtc accttctcgg gtatccccgt cagaaagaaa
       61 ccctcgggac tactttttcc acagtcgcag agactcactg gttccactta attgtggaat
      121 ctctaggctg gctcccattc agaagcagta tactgcccac tggcccacca cctcagggga
      181 acgatggcca cagagtctac agccactgct gccatcgccg cggaactggt ttccgctgac
      241 aaagttgaag atgctcctgc tccttctacc tctgcagata aaatggagag tctggatgtg
      301 gatagtgaag ctaagaaact actgggatta ggacagaaac atctggtgat gggtgacatt
      361 ccagcagctg ttaatgcatt ccaagaagca gctagtcttt taggtaagaa gtatggagaa
      421 acggctaatg agtgtggaga agccttcttt ttttatggga agtcacttct ggagttggcc
      481 agaatggaga atggagtgtt gggaaatgcc ttagaaggag tgcatgtaga agaggaagaa
      541 ggagaaaaaa cagaagatga atctttggta gaaaataatg ataatgtaga tgaggaagca
      601 agggaagagt tgagagaaca ggtttatgac gccatgggag aaaaagaagc caaaaaagca
      661 gaaggccagt ctctgacaaa gcctgaaact gataaagaac aggaaagtga agtggagaag
      721 ggtggaagag aagatatgga tataagtgag cctgcagaga agctccagga aaaagttgaa
      781 tcgacttcaa agcagttaac tgaatcctct gaagaggcaa aagaagcagc aataccagga
      841 ctgaatgaag atgaggtcac ttctgggaag acagaacagg aatcattgtg tactgaggaa
      901 ggaaaatcca tttctggagt ttatgttcaa aataaagaat tcagagaagc agtgcctcag
      961 gaggagggag aggaaatgat aagcttagaa aaaaagccaa aagaaacttc agaagatcag
     1021 actattgggg ctccagaaaa gcaggacact ttaatgaagg tggtagaaat agaagctgaa
     1081 atagactctg aagtcaagtc agtggatgtg ggtggggagg agccgaagga tcagggagct
     1141 atctctgaga gtgaactagg aaaggctgtt cttatgcaac tctcagggca agatgttgaa
     1201 gtatcaccag tagtggctgc agaggctgga tcagaagtct ctgagaagcc agggcaggag
     1261 attacagttc ttcccaacaa tggtccagtt gttggacaat catctgcagg agatcaaact
     1321 cctagtgaac cacagaattc tgcagaaaga ctgtcagaaa ctaaagatgg cgcaagtgta
     1381 gaggaggtca aggcagagct ggttcctgaa caggaggaag ctatgcctcc tgtagaagag
     1441 tctgaggcag ctggagatgg ggttgagacc aaggtagccc agagggccac ggagaaagca
     1501 cctgaagaca aatttaagat agctgctaat gaagagacac aagagagaga cgaacagatg
     1561 aaagagggtg aagaaactga aggctcagag gaagaagaca aagaaaatga caaggctgaa
     1621 gaaacaacaa atgaatcagt tcttgaaaaa aagactcttc aagaaaatga agaagaggag
     1681 attgggaatt tagaacttgc ctgggatatg ctagatttag ccaagattat ttttaagagg
     1741 caagaaacaa aagaagccca gctttatgct gcacaagccc atcttaaact tggagaagtt
     1801 agtgttgaat ctgagaatta tatccaagct gtggaggagt ttcaggcttg cctaagcctg
     1861 caagagcagt atttggaagc tcacgatcgt ctccttgcgg agactcacta ccagttgggt
     1921 ttggcctatg gttacaactc tcagtatgat gaggctgtag cacagtttgg caaatctatt
     1981 gacgtcattg agaagagaat ggctgtacta cttgagcaga tgaaggaggc tgaaggatca
     2041 tttactgaat acgagaaaga aatcgaggag ctgaaagaac tgctccccga gattcgggag
     2101 aagatagagg atgcaaagga gtctcagcgg agtgggaatg tagctgagct ggctctgaag
     2161 gccactctgg tcgagagctc tacttcaggt ttcactccta gtggagctgg tgcctcggta
     2221 tccatgattg ccagtagaaa accaacagat ggcgcttcct catcaaactg tgtcactgat
     2281 atttctcatc ttgtcagaaa gaagaggaaa ccagaggaag agagtccccg gaaagatgat
     2341 gcaaagaaag ctaaaccaga accagaggtg aatggaggca gtggagatgc tgtctccagt
     2401 ggaaatgaag tttcagaaaa catggaggca gaggctgaga atcaggctga gagccagaca
     2461 acagcagaag ggacagtgga ctctgcagct acagttaaaa gcactgcatg ttaagaggcg
     2521 agcagaacct tcctcctgag ggaaagtggt tttgtacata atgtattttt tcacttttgg
     2581 ggattctttt tgtataactc caataaagat tgtaggcaac agctgagact ttgatggctt
     2641 ttttcttaaa aatattggtg gattgttttg gggcactcta tattgtgtat acatgccttg
     2701 tgttttgcta ctgcacaacc cacttcctgt ctaatgtgga ggtgatcaag ttgatcaagg
     2761 cccttcatct actggtgcta tgtttctatt tccaaatatt tggctgaatt caaatacctt
     2821 gtaagctttc catggtgctg tccctggatg gggtctgcta aacaagaact ggtagaaatc
     2881 agtttggtgc tgaaaatgga gcatggaata tgacccaggt cttggtttgt gcctaccttc
     2941 tgttcacctg gtttccattt aaggccataa tatcctgccc tggcaaaact ggcagaaaca
     3001 tgggaaatga ttcctgagga aaactgttgt tagatactcc gtaggatcac actgtagtgg
     3061 gagacaagta gaagactatg attgagaagt ctgttacgtt attttctgta tagaaagatt
     3121 acaatatgtc aataagtgga attgttatat tgtgcagttt tgtctataaa aataaatatg
     3181 ctaattttaa caaa
//
LOCUS       NM_001436692            1419 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 8, mRNA.
ACCESSION   NM_001436692
VERSION     NM_001436692.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1419)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2101463.1,
                                           SRR26360181.817975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-550             JAXUCZ010000016.1  7308347-7308453
            551-692             JAXUCZ010000016.1  7309595-7309736
            693-1419            JAXUCZ010000016.1  7311040-7311766
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1419
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..956
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 4 is encoded by transcript variant 8;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 4"
                     /protein_id="NP_001423621.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKRLQRILACVGTSCKERKE
                     ANRSRCYRSSRTDACWGTWSIVQQSSWESRLSVLAAVQLSEEKSYPENQKQAIFVASN
                     MPLFWALKLAN"
     misc_feature    468..>698
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    468..>698
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..692
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1419
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gaggtcatgg ctgcagctaa ggtgtgtgag atcactcacg
      481 agtctccatc agtgaagagc ctccgtttgc ttgttgctga taaagacttt tccttcaagg
      541 ctggccagtg ggttgatttc ttcatcccag gagtttcagt ggttggtggg ttttcaattt
      601 gctccagtcc ccaacagcta gaacgagaga gaataataga attggcagtg aaatacacga
      661 accatcctcc tgctgtctgg gttcacaata agaggttgca gagaattctt gcttgtgtgg
      721 gaacttcgtg taaggagagg aaggaagcca acaggagcag atgttaccgg agcagcagga
      781 cagatgcgtg ctgggggacg tggagcatcg ttcagcagag cagctgggag agcaggttga
      841 gtgtactggc tgcagttcag cttagtgagg agaagagcta cccagagaat cagaaacaag
      901 ccatatttgt agcaagtaac atgcccttgt tttgggcact gaaacttgca aactaggtca
      961 ctctcttgat ccatcctcca gtaagaatca tcaaaaaaaa aaaaaaagtt gtaaaattat
     1021 aaaagttctt ttaccctgaa ctagctctgg caccgcagcg ccccaagata tctgattctc
     1081 catctcagtc agcagagact ctcacctgtt tgctccatct cgtatcacac gccgatggct
     1141 tctctctgag cccggcaaca atctctccac ccatctagtt cacccttttt gtctaattaa
     1201 aaaaaacttt tctctcagat ataagctgag cacaactatt atcattttgt aattaaaaga
     1261 ataaaatata tctaacacct agtccaacat tttatcagtt aagcagaaca tttagttatc
     1321 cattccagct taaggaaggc ttaaaatctg tattatatct tggctagctt gtatactatc
     1381 tgataagtat ccaataaaat atgtattttc agagttaaa
//
LOCUS       NM_001436716            2423 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1-like (Mtfr1l),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001436716
VERSION     NM_001436716.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2423)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16497.1,
                                           SRR26643296.16349.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  152030080-152030231 c
            153-278             JAXUCZ010000005.1  152027744-152027869 c
            279-383             JAXUCZ010000005.1  152027268-152027372 c
            384-493             JAXUCZ010000005.1  152025746-152025855 c
            494-705             JAXUCZ010000005.1  152025303-152025514 c
            706-1027            JAXUCZ010000005.1  152024076-152024397 c
            1028-2423           JAXUCZ010000005.1  152020175-152021570 c
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2423
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="mitochondrial fission regulator 1-like"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
     exon            1..152
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            153..278
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    189..191
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="upstream in-frame stop codon"
     CDS             264..1133
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="isoform a is encoded by transcript variant 3;
                     protein FAM54B; family with sequence similarity 54, member
                     B"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1-like isoform
                     a"
                     /protein_id="NP_001423645.1"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
                     /translation="MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPN
                     ISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVP
                     NLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSSG
                     SSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTT
                     CSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRK
                     FALKEEDISRKGN"
     misc_feature    282..1013
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    282..1013
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    342..344
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    375..377
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    561..563
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    582..584
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    924..926
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    927..929
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    966..968
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    1035..1037
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    1071..1073
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     exon            279..383
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            384..493
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            494..705
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1027
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2423
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgctggc caagtcactc agcggttggg gtcgacccag ccgttggagt gcgatacgcc
       61 cgggccgcgc ggcgtttctg ggacctacgc cggcctggag gctattgtgc gctccggccc
      121 ggcccgtggg tccaagggcc gctggacgcg cggaaaggaa gtctcatgct ccgggaaatg
      181 gcctgatatg aaggagtcac acctccagcc ttccctgtgg gtgccttgtc ctttgggtgc
      241 aggagctggc tgaaacatca ggaatggaag ccaatgtgac tatcccaatc tggcagaaca
      301 agccacatgg ggctgctcgc agtgtggtaa gaagaattgg gaccaatctg cccctgaaac
      361 cttgtccacg ggcatccttt gagaccctgc ccaacatctc tgacctgtgt ttgaaagatg
      421 tgcctccagt cccgactctg gctgacatcg cctggattgc cgcagatgaa gaggagacat
      481 atgctcgggt caggagcgat acacgccctc tgagacatac ctggaagccc agccctctga
      541 ttgtcatgca acggaatgcc tcagtgccca atctgcgtgg gtctgaggag aggctcctgg
      601 ccctgaagaa gccagccctg cctgccctaa gccgcaccac tgagctgcag gatgaactaa
      661 gccacctgcg cagccagatt gctaaaatag tggcagcaga tgcagcttcg gcctcattaa
      721 cgccagattt cttatcttca ggaagttcaa atgtctcctc tcctttgcct tgctttggat
      781 cctcattcca ctctacaact tcctttgtca ttagtgacat cactgaggag actgaggttg
      841 aggtccccga gcttccaaca atccccctgc tttgttctgc cagccctgaa tgttgcaaat
      901 cagaacacaa aactacctgc agctcgtctg aagaggatga ctgcatctct ctgtccaagg
      961 ccagcagctt tgcagacatg atgggcatcc tgaaggattt tcatcggata aaacagagcc
     1021 aagacctgag ccggagttta ctgaaggaag aagaccctgc tgtccttatc tctgaggtcc
     1081 ttaggaggaa gtttgccctg aaggaagaag acatcagtag aaaaggaaac tgacagcact
     1141 gactgcaaac tcttctcttg ctcctgaact ccttcaatag ctgccttcct cactgcagat
     1201 gtctgtctca gttgagatct gaacagtctt gctgactagg gcttgggctg gaagagaaga
     1261 gctggattat ttgttacctg cacttaaacc ctggcagagt ctaaggtcta tggtttttgg
     1321 agatgtgaca tttgttacag gtaattgggt agagtggagt atctctgctt aaggcgtgaa
     1381 gtttgttttt tcttgtctct gaaaaataag ccctctatga atgacttaat taactcactg
     1441 cattagactc cataattggt ctcactggac atgttgtgca cagcagtcac tctcggcagc
     1501 ttccctgcag caccacaggg ctgaggggga gcggctgtta gttcatgctc acaggaaggt
     1561 cttctgctgc ttcatcacag acatacacca gtgcccacag tcaccctttc cctctagctg
     1621 cagagggcag gccactgggc cagccaatat ctgggctgct gcagggaggc ctggcctgtt
     1681 ttttcttaaa cattttataa aactacaacc tgatctaccc tccagggcct cattagttcc
     1741 actgattgaa tttttttttc ttccatggac ttactaagtc catcttggaa ggagaaatgt
     1801 ggagacaaaa agagcatacc atccttctag gacagtgact gatctctcta ggttgggtca
     1861 agattttatt tactgcatca tgcatgactc aggtgccctc agggcccttt tctctatggt
     1921 atgaatactg tgtgttttga gttgaagcat tacctgatat taaatgaagg atttggagaa
     1981 atggtgtagt ttttctttat tctgtctctg aattttgacc acagtggcct ctggtgaaga
     2041 gagggctcct gttgattcta aggtatgtga acttttaaaa aacaggctcc tgacttcctt
     2101 tcttgccctc aggacagtgg tgctcactgt gaccctttaa tacaagtcct tatgctatgg
     2161 tgaccccctc tccccacatc cataaaattt tgttgctact tcataactaa atttgctacc
     2221 attaagagtt gtaatatggg ctgtatagac ggctcagtgg ttgggagcac tgactgttct
     2281 ttccggaggt tctgagttca aatcccagca atgacatcgt ggctcaaaac catctgtaat
     2341 gagatccgat gccctcttct ggtgtgtctg aagacagcta cagtgtactt acatataata
     2401 aataaataaa tcttaaaaaa aaa
//
LOCUS       NM_001436710            3040 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 7, mRNA.
ACCESSION   NM_001436710 XM_006238801
VERSION     NM_001436710.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3040)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3040)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3040)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3040)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3040)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238801.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.120708.1,
                                           SRR26360181.873338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2289           JAXUCZ010000005.1  140860181-140860252
            2290-2417           JAXUCZ010000005.1  140860911-140861038
            2418-2511           JAXUCZ010000005.1  140862618-140862711
            2512-2642           JAXUCZ010000005.1  140862797-140862927
            2643-2739           JAXUCZ010000005.1  140863198-140863294
            2740-3040           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3040
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2732
                     /gene="Pabpc4"
                     /note="isoform 7 is encoded by transcript variant 7;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 7"
                     /protein_id="NP_001423639.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGVPTAVPNLAPRATVAAAAPRAVAPYKYASNVRSPHPAIQ
                     PLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLL
                     EIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGTVAAATS"
     misc_feature    915..2669
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2669
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2289
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2417
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2511
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2642
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2739
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..3040
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg cgtccctacg gctgtgccaa accttgcacc tcgtgctaca gtcgctgctg
     2341 ctgctcccag ggctgtggct ccatacaagt atgcctccaa tgtccgcagc cctcaccctg
     2401 ccattcagcc gctgcaggcc ccccagcctg cagtccatgt ccagggtcaa gaacccctga
     2461 ctgcctccat gctggctgca gctcctcccc aggagcagaa gcagatgctg ggggagcgtt
     2521 tgttcccact tatccaaaca atgcattcaa acctggctgg aaaaattaca gggatgctgc
     2581 tagaaatcga caactctgag ctgctccaca tgctggagtc ccccgagtcc ctccgttcca
     2641 aggtggatga agctgtggca gtcctgcagg ctcatcatgc caagaaagaa gctgcccaga
     2701 aggtgggcac tgttgctgct gctacctctt aaaccagaag agtcaaaagc caaataaccc
     2761 ctcacggcat tcagctgagg tctgaagact tcctagtttg tctgtggacc tctttcaaga
     2821 accaagttac aaattcaaca ggtcattttg tatcaaaagg tcaattatga agcacctaga
     2881 atttttcaat tataagaata tattctctgg gttctgttgt ggcccagatg atggtaactt
     2941 ttttttctat tatgagttct gttttttttc ccctctccca gaaattggtt ttgatgtacc
     3001 caagacttaa gtttctcaat aaaggaaata aaatctccaa
//
LOCUS       NM_001436696            3245 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 3, mRNA.
ACCESSION   NM_001436696 XM_008763993
VERSION     NM_001436696.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 3245)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 3245)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 3245)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 3245)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 3245)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 3245)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 3245)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3245)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 3245)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_008763993.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29399.1,
                                           SRR26360181.1716953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000005.1  135319415-135319609 c
            196-293             JAXUCZ010000005.1  135319012-135319109 c
            294-341             JAXUCZ010000005.1  135314949-135314996 c
            342-452             JAXUCZ010000005.1  135311284-135311394 c
            453-533             JAXUCZ010000005.1  135306753-135306833 c
            534-643             JAXUCZ010000005.1  135304577-135304686 c
            644-1624            JAXUCZ010000005.1  135302980-135303960 c
            1625-1704           JAXUCZ010000005.1  135298279-135298358 c
            1705-1790           JAXUCZ010000005.1  135297655-135297740 c
            1791-1864           JAXUCZ010000005.1  135297473-135297546 c
            1865-2053           JAXUCZ010000005.1  135296880-135297068 c
            2054-2220           JAXUCZ010000005.1  135296609-135296775 c
            2221-2277           JAXUCZ010000005.1  135296062-135296118 c
            2278-2355           JAXUCZ010000005.1  135295896-135295973 c
            2356-2484           JAXUCZ010000005.1  135295084-135295212 c
            2485-3245           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3245
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..195
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    178..180
                     /gene="Nasp"
                     /note="upstream in-frame stop codon"
     exon            196..293
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2565
                     /gene="Nasp"
                     /note="isoform a is encoded by transcript variant 3;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform a"
                     /protein_id="NP_001423625.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAE
                     GQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIP
                     GLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETS
                     EDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLS
                     GQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSE
                     TKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANE
                     ETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWD
                     MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEA
                     HDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYE
                     KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMI
                     ASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSG
                     NEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     misc_feature    238..240
                     /gene="Nasp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    331..333
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    361..462
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    577..957
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    580..615
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    601..603
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    613..615
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    <622..1752
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <622..1752
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    739..741
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    757..759
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    796..798
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    862..960
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    955..957
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    958..960
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    985..987
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    1000..1101
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1090..1092
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    1150..1152
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1195..1197
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1267..1725
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1369..1371
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1390..1392
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1426..1428
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1588..1590
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1603..1734
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    1627..1629
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1636..1638
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1678..1680
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1687..1689
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1729..1800
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1729..1800
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1816..2046
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1816..2046
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1822..1935
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1822..1935
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1822..1923
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    1822..1908
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1822..1908
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1825..1827,1834..1839,1846..1851,1855..1857,
                     1951..1953,1960..1965,1972..1977,1981..1986,2047..2049,
                     2056..2061,2068..2070)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1825..1827,1834..1839,1846..1851,1855..1857,
                     1951..1953,1960..1965,1972..1977,1981..1986,2047..2049,
                     2056..2061,2068..2070)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1921..2037
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1921..2037
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1948..2049
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    2182..2184
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2245..2247
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2287..2562
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2311..2313
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2314..2316
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2344..2364
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    2374..2376
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2431..2433
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2449..2451
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2464..2466
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     exon            294..341
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            342..452
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            453..533
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            534..643
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1624
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1704
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1790
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1864
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2053
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2220
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2277
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2355
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2484
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..3245
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagactgaga gggcataggg aagacctgtc accttctcgg gtatccccgt cagaaagaaa
       61 ccctcgggac tactttttcc acagtcgcag agactcactg gttccactta attgtggaat
      121 ctctaggctg gctcccattc agaagtagta ccgagatttt ggtgcttcta acacgactag
      181 ccacagaagc aggaagcagt atactgccca ctggcccacc acctcagggg aacgatggcc
      241 acagagtcta cagccactgc tgccatcgcc gcggaactgg tttccgctga caaagttgaa
      301 gatgctcctg ctccttctac ctctgcagat aaaatggaga gtctggatgt ggatagtgaa
      361 gctaagaaac tactgggatt aggacagaaa catctggtga tgggtgacat tccagcagct
      421 gttaatgcat tccaagaagc agctagtctt ttaggtaaga agtatggaga aacggctaat
      481 gagtgtggag aagccttctt tttttatggg aagtcacttc tggagttggc cagaatggag
      541 aatggagtgt tgggaaatgc cttagaagga gtgcatgtag aagaggaaga aggagaaaaa
      601 acagaagatg aatctttggt agaaaataat gataatgtag atgaggaagc aagggaagag
      661 ttgagagaac aggtttatga cgccatggga gaaaaagaag ccaaaaaagc agaaggccag
      721 tctctgacaa agcctgaaac tgataaagaa caggaaagtg aagtggagaa gggtggaaga
      781 gaagatatgg atataagtga gcctgcagag aagctccagg aaaaagttga atcgacttca
      841 aagcagttaa ctgaatcctc tgaagaggca aaagaagcag caataccagg actgaatgaa
      901 gatgaggtca cttctgggaa gacagaacag gaatcattgt gtactgagga aggaaaatcc
      961 atttctggag tttatgttca aaataaagaa ttcagagaag cagtgcctca ggaggaggga
     1021 gaggaaatga taagcttaga aaaaaagcca aaagaaactt cagaagatca gactattggg
     1081 gctccagaaa agcaggacac tttaatgaag gtggtagaaa tagaagctga aatagactct
     1141 gaagtcaagt cagtggatgt gggtggggag gagccgaagg atcagggagc tatctctgag
     1201 agtgaactag gaaaggctgt tcttatgcaa ctctcagggc aagatgttga agtatcacca
     1261 gtagtggctg cagaggctgg atcagaagtc tctgagaagc cagggcagga gattacagtt
     1321 cttcccaaca atggtccagt tgttggacaa tcatctgcag gagatcaaac tcctagtgaa
     1381 ccacagaatt ctgcagaaag actgtcagaa actaaagatg gcgcaagtgt agaggaggtc
     1441 aaggcagagc tggttcctga acaggaggaa gctatgcctc ctgtagaaga gtctgaggca
     1501 gctggagatg gggttgagac caaggtagcc cagagggcca cggagaaagc acctgaagac
     1561 aaatttaaga tagctgctaa tgaagagaca caagagagag acgaacagat gaaagagggt
     1621 gaagaaactg aaggctcaga ggaagaagac aaagaaaatg acaaggctga agaaacaaca
     1681 aatgaatcag ttcttgaaaa aaagactctt caagaaaatg aagaagagga gattgggaat
     1741 ttagaacttg cctgggatat gctagattta gccaagatta tttttaagag gcaagaaaca
     1801 aaagaagccc agctttatgc tgcacaagcc catcttaaac ttggagaagt tagtgttgaa
     1861 tctgagaatt atatccaagc tgtggaggag tttcaggctt gcctaagcct gcaagagcag
     1921 tatttggaag ctcacgatcg tctccttgcg gagactcact accagttggg tttggcctat
     1981 ggttacaact ctcagtatga tgaggctgta gcacagtttg gcaaatctat tgacgtcatt
     2041 gagaagagaa tggctgtact acttgagcag atgaaggagg ctgaaggatc atttactgaa
     2101 tacgagaaag aaatcgagga gctgaaagaa ctgctccccg agattcggga gaagatagag
     2161 gatgcaaagg agtctcagcg gagtgggaat gtagctgagc tggctctgaa ggccactctg
     2221 gtcgagagct ctacttcagg tttcactcct agtggagctg gtgcctcggt atccatgatt
     2281 gccagtagaa aaccaacaga tggcgcttcc tcatcaaact gtgtcactga tatttctcat
     2341 cttgtcagaa agaagaggaa accagaggaa gagagtcccc ggaaagatga tgcaaagaaa
     2401 gctaaaccag aaccagaggt gaatggaggc agtggagatg ctgtctccag tggaaatgaa
     2461 gtttcagaaa acatggaggc agaggctgag aatcaggctg agagccagac aacagcagaa
     2521 gggacagtgg actctgcagc tacagttaaa agcactgcat gttaagaggc gagcagaacc
     2581 ttcctcctga gggaaagtgg ttttgtacat aatgtatttt ttcacttttg gggattcttt
     2641 ttgtataact ccaataaaga ttgtaggcaa cagctgagac tttgatggct tttttcttaa
     2701 aaatattggt ggattgtttt ggggcactct atattgtgta tacatgcctt gtgttttgct
     2761 actgcacaac ccacttcctg tctaatgtgg aggtgatcaa gttgatcaag gcccttcatc
     2821 tactggtgct atgtttctat ttccaaatat ttggctgaat tcaaatacct tgtaagcttt
     2881 ccatggtgct gtccctggat ggggtctgct aaacaagaac tggtagaaat cagtttggtg
     2941 ctgaaaatgg agcatggaat atgacccagg tcttggtttg tgcctacctt ctgttcacct
     3001 ggtttccatt taaggccata atatcctgcc ctggcaaaac tggcagaaac atgggaaatg
     3061 attcctgagg aaaactgttg ttagatactc cgtaggatca cactgtagtg ggagacaagt
     3121 agaagactat gattgagaag tctgttacgt tattttctgt atagaaagat tacaatatgt
     3181 caataagtgg aattgttata ttgtgcagtt ttgtctataa aaataaatat gctaatttta
     3241 acaaa
//
LOCUS       NM_001436714            5308 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 3 receptor (Csf3r),
            transcript variant 4, mRNA.
ACCESSION   NM_001436714 XM_039109623
VERSION     NM_001436714.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5308)
  AUTHORS   Zhang,E., Lee,S., Yi,M.H., Nan,Y., Xu,Y., Shin,N., Ko,Y., Lee,Y.H.,
            Lee,W. and Kim,D.W.
  TITLE     Expression of granulocyte colony-stimulating factor 3 receptor in
            the spinal dorsal horn following spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Mol Med Rep 16 (2), 2009-2015 (2017)
   PUBMED   28656207
  REMARK    GeneRIF: the expression of GCSFR in neurons following peripheral
            nerve injury may be involved in the induction and maintenance of
            neuropathic pain through the STAT3 and TRPV1 signaling pathway.
REFERENCE   2  (bases 1 to 5308)
  AUTHORS   Aref,S., El-Ghonemy,M., Abouzeid,T., El-Sabbagh,A. and El-Baiomy,M.
  TITLE     Prevalence and impact of colony stimulating factor 3 receptor
            (CSF3R) mutations among Egyptian acute myeloid leukemia patients
  JOURNAL   Leuk Res 38 (6), 722-725 (2014)
   PUBMED   24746896
REFERENCE   3  (bases 1 to 5308)
  AUTHORS   Fleischman,A.G., Maxson,J.E., Luty,S.B., Agarwal,A., Royer,L.R.,
            Abel,M.L., MacManiman,J.D., Loriaux,M.M., Druker,B.J. and
            Tyner,J.W.
  TITLE     The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in
            mice that is responsive to therapeutic JAK inhibition
  JOURNAL   Blood 122 (22), 3628-3631 (2013)
   PUBMED   24081659
REFERENCE   4  (bases 1 to 5308)
  AUTHORS   Kosmider,O., Itzykson,R., Chesnais,V., Lasho,T., Laborde,R.,
            Knudson,R., Gauthier,A., Merlevede,J., Ades,L., Morabito,M.,
            Fontenay,M., Tefferi,A., Droin,N. and Solary,E.
  TITLE     Mutation of the colony-stimulating factor-3 receptor gene is a rare
            event with poor prognosis in chronic myelomonocytic leukemia
  JOURNAL   Leukemia 27 (9), 1946-1949 (2013)
   PUBMED   23774674
REFERENCE   5  (bases 1 to 5308)
  AUTHORS   Hanumanthu,V.S. and Pirruccello,S.J.
  TITLE     GCSF-R expression in myelodysplastic and myeloproliferative
            disorders and blast dysmaturation in CML
  JOURNAL   Am J Clin Pathol 140 (2), 155-164 (2013)
   PUBMED   23897249
REFERENCE   6  (bases 1 to 5308)
  AUTHORS   Semerad,C.L., Poursine-Laurent,J., Liu,F. and Link,D.C.
  TITLE     A role for G-CSF receptor signaling in the regulation of
            hematopoietic cell function but not lineage commitment or
            differentiation
  JOURNAL   Immunity 11 (2), 153-161 (1999)
   PUBMED   10485650
REFERENCE   7  (bases 1 to 5308)
  AUTHORS   Otsuji,W., Tanase,S., Yoshida,S. and Bawden,J.W.
  TITLE     The immunohistochemical localization of the interferon-gamma and
            granulocyte colony-stimulating factor receptors during early
            amelogenesis in rat molars
  JOURNAL   Arch Oral Biol 44 (2), 173-181 (1999)
   PUBMED   10206335
REFERENCE   8  (bases 1 to 5308)
  AUTHORS   Hermans,M.H., Ward,A.C., Antonissen,C., Karis,A., Lowenberg,B. and
            Touw,I.P.
  TITLE     Perturbed granulopoiesis in mice with a targeted mutation in the
            granulocyte colony-stimulating factor receptor gene associated with
            severe chronic neutropenia
  JOURNAL   Blood 92 (1), 32-39 (1998)
   PUBMED   9639496
REFERENCE   9  (bases 1 to 5308)
  AUTHORS   Dong,F., Dale,D.C., Bonilla,M.A., Freedman,M., Fasth,A.,
            Neijens,H.J., Palmblad,J., Briars,G.L., Carlsson,G., Veerman,A.J.,
            Welte,K., Lowenberg,B. and Touw,I.P.
  TITLE     Mutations in the granulocyte colony-stimulating factor receptor
            gene in patients with severe congenital neutropenia
  JOURNAL   Leukemia 11 (1), 120-125 (1997)
   PUBMED   9001427
REFERENCE   10 (bases 1 to 5308)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_039109623.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7664.1,
                                           SRR26360194.1669309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JAXUCZ010000005.1  143583210-143583447
            239-329             JAXUCZ010000005.1  143584764-143584854
            330-413             JAXUCZ010000005.1  143586042-143586125
            414-713             JAXUCZ010000005.1  143588148-143588447
            714-837             JAXUCZ010000005.1  143590265-143590388
            838-1025            JAXUCZ010000005.1  143590587-143590774
            1026-1228           JAXUCZ010000005.1  143591992-143592194
            1229-1382           JAXUCZ010000005.1  143592279-143592432
            1383-1462           JAXUCZ010000005.1  143593262-143593341
            1463-1676           JAXUCZ010000005.1  143593661-143593874
            1677-1859           JAXUCZ010000005.1  143594985-143595167
            1860-1961           JAXUCZ010000005.1  143595483-143595584
            1962-2108           JAXUCZ010000005.1  143597332-143597478
            2109-2249           JAXUCZ010000005.1  143597586-143597726
            2250-2340           JAXUCZ010000005.1  143600615-143600705
            2341-2422           JAXUCZ010000005.1  143600867-143600948
            2423-5308           JAXUCZ010000005.1  143601497-143604382
FEATURES             Location/Qualifiers
     source          1..5308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5308
                     /gene="Csf3r"
                     /note="colony stimulating factor 3 receptor"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
     exon            1..238
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            239..329
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Csf3r"
                     /note="upstream in-frame stop codon"
     exon            330..413
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..2899
                     /gene="Csf3r"
                     /note="isoform b precursor is encoded by transcript
                     variant 4; granulocyte colony-stimulating factor receptor;
                     colony stimulating factor 3 receptor (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     isoform b precursor"
                     /protein_id="NP_001423643.1"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
                     /translation="MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLA
                     SCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFC
                     LVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKL
                     CIDPMDVGRESLTTPPPAVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQ
                     ECELRYQPQLEGANWTLVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWS
                     PGLQLRPTIKAPTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCP
                     DGQGRIMHLCNTTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLH
                     AMAQDLGSIWVDWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHP
                     FQLYRITVAPLYPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWL
                     GMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNST
                     GLTLMTMALDSSDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLS
                     AWVPTIMTEETFQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAY
                     VLQGDPREISNQFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPK
                     SYENIWFHSRPQETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     sig_peptide     350..424
                     /gene="Csf3r"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    419..682
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    419..682
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    716..1012
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    716..1012
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    1679..1945
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1679..1945
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1919..1924,1928..1933)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1919..1924,1928..1933)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1967..1969,2159..2161,2204..2206)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1967..1969,2159..2161,2204..2206)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    1976..2209
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1976..2209
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     exon            414..713
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            714..837
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1025
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1228
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1382
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1462
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1676
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1859
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1961
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2108
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2249
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2340
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2422
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..5308
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggagag gagacaagag aagagagagc aaacgtgggg gctgggcaca gcgccccagc
       61 cccaatgtaa gtagggggag ggcggagccc tgaaggcctc agaccattcc ccagccctga
      121 cagggtcaca tcagggggcc caagacaggg gatccttcgg aaatggaagg ctctctgtgt
      181 gtatagcatc aggaaagtca gacagctgga tctctttggg aacaggagct gagctcagca
      241 ttgctgagac atgagcataa gccccttttc ccaaatggag aaattgagac tcagaaaggt
      301 gaagtaaccc atccaagttc accaggcagg taaacaccaa gctggcgaaa tggtggggct
      361 gggagcctgc aacctgactg gagttaccct gattgtcttg ctactcccca gaagtctgga
      421 gggctgcggg caaatcagga tctcaccccc cattgtccat cttggggatc ctgtcctggc
      481 ctcctgcacc atcagcccaa actgcagcaa actggaccga cagccaaaga tcctatggag
      541 actgcaagat gaaccaaacc agcctgggga cagacagcat cacctgcctg acgggtccca
      601 ggagtccatc atcactctgc ctcatctgaa ctacactcag gccttcctct tctgcttggt
      661 gccatggaac aacagcttcc aggtcctgga tcaagctgag cttcgtgcag gctatcctcc
      721 tgccagcccc tccaacctat cctgcctcat gtacctcacc accaacagcc tggtctgcca
      781 gtgggagcca ggccccgaga cccacctgcc cactagcttc atcctaaaga gcttcaggag
      841 ccgcaccggc tgtcagtacc aggggggcac catcctggac tgtatgccca agaagagaca
      901 cagcaactgc tccatccccc gcaaacactt gcttctgtac cagaatatgg tcatctgggt
      961 gcaagcggag aatatgctag ggtccagcga gtccccaaag ctgtgcattg accccatgga
     1021 tgttggcagg gaaagtttga caaccccacc tcctgcagtg aaattggagc ctcccatgct
     1081 gcaggccctg gacattggcc atgatatagt ctctcgccag cctggctgcc tatggctgag
     1141 ctggaagcca tggaagccca gtgagttcat ggagcaggag tgtgaactcc gttaccagcc
     1201 acagcttgaa ggagccaact ggaccctggt gtcccacctg ccttccagca cggaccggtt
     1261 cgagctctgc agccttcatc aagccccagt ctacacccta cagttgcgat gcatccgctc
     1321 atctctgcct ggactctgga gcagctggag ccctggcctt cagctgaggc ccaccattaa
     1381 ggcccccacc atcagactgg acacatggtg gcagaagaag catctggatc ctgagacagt
     1441 gagaatgcag ctgttctgga agccaacacc cctgcagaaa gacagtggac agatccaggg
     1501 ctacctgctc tcctggagtt gcccagatgg gcaagggcgg atcatgcacc tctgtaacac
     1561 cacagagctc agctgcacct tccacctgcc ctcagaggcc cagaacgtga cccttgtggc
     1621 ctacaactcg gcggggacct cctcccctac tctggtggtt ttcctggagc acgaaggtcc
     1681 agctgtgacc agcctgcatg ccatggccca agaccttggt agcatctggg tagactggga
     1741 agcccccagc cttctgcctc agggctatct cattgagtgg ggcccggatt cccacaaata
     1801 cagcaataat tcctggagga tagagcccaa tgggaacacc actggaattc tgttagagga
     1861 caatatacat ccctttcaac tctacagaat cacagtggct cccctgtacc caggcaccgt
     1921 gggaccccct gtaaatgtct acacctactc tggagagaaa gcccttcctc atgctccaga
     1981 gctatatcta aagcatgttg gcaggacctg ggcacagttg gagtgggtac ctgagacccc
     2041 ttggctgggg atgatacccc tcaccaacta caccatcttc tggaccgatg ctcgggacca
     2101 ctccttctct gtcaccctga acatctcctt tcatgacttt gtcctggacc acctgaaacc
     2161 tgccagtttg tatcacgtct acctcatggc caccagccgg gcagggtcca ccaacagtac
     2221 aggccttacc ctgatgacca tggccctaga ttcatctgat gtaaacattt tcctgggcat
     2281 actttgcttc gtacttttgt ccattacctg tgcaactgcc tggttctgct gcaagcaaag
     2341 cagaaagact ttcttctggc caaatgtgcc agacccagcc cacagcagtc tgagcgcctg
     2401 ggtgcccacc atcatgacag aggaaacctt ccagctgccc agcttctggg gctccagtgt
     2461 gccgtcaatc accaagatca ctgaactgga ggaggacaag aaaccgaccc actgggatcc
     2521 cagtgagagc tctgggactg ggagccttcc agccgtggtt caggcttacg tgctccaagg
     2581 agacccaaga gaaatttcca accagttcca gcctccctct agcactaatg accaggttct
     2641 ctatggtcag gtgcttggga gccccaccag cccagaagta gtgggatacc ttcggtgtga
     2701 ctccactcag cccctcttgg gaggccccac acccagccct aaatcctatg aaaacatctg
     2761 gttccattca agaccccagg agacctttat accccaacct ccaagccagg aagatgactg
     2821 tgtctttgga cctccatttg atttccccct cttccagggg ctccaggtcc atggagttga
     2881 agaacaaggg ggtttctagg acttttgggg tccttacatc ctgaaggccc tggcctattc
     2941 aggaaagatc ccaccactaa tatctactgg tcctgaggga aacagaaagg ccctatttgt
     3001 ctccagctgt ggcccctagg acctctcctt cactctaacc tccacaggct acacccctag
     3061 gtctttctca cactccaagg tccagataca tactgtttac agcccactag tcaccttgtg
     3121 tctctcatat aatttcagtc cgttaaactg agtgtaggtt ttgagcaggg actagcacgt
     3181 tcacaaatcc tggctggacg tagtgataca tgcctagcat cccaactcaa acgtttggga
     3241 ggaagatgca ggaggattgc aagttccagg ccagcctggg ctatatgaag agatcctgcc
     3301 tcagaaatta agcaaaagcc aaataaaatt tttttattac atttactttt tgttggtggg
     3361 gttgggggct cacaggcaaa ggtcagacac cttaagggaa ttaactctgg cctccagcct
     3421 gtggattttg ggaggtgaac gtaaggttta gtggcaagca tctttcccca gggaggcatt
     3481 tcactagtcc cagagaggag tctcttaagt atagctaagt gtcttttaca cttgtctgtc
     3541 tgtctgtttt tcaaaaaaag gtttctctgt gtacctgtcc tatctgtcct ggaactcact
     3601 ctgtagaaca ggctggcctc aaactcagag atccacctgc ctctgtcttc tgaatggtgg
     3661 gaataaaggc ctgcacacca ccacccagca gtgtcatttc ctctcagggc ccagcagtca
     3721 tgaagctatt tctcagtcag tcatctgttc cgttccttcc ctcctcttcc tccttccttc
     3781 cttccctccc ttcctctttc cttccttcct tccttccctc cctccctccc tccctccttc
     3841 cttccttcct tccttccttc cttccgtcct cttgcctagc atctaagatt caaaagagac
     3901 aacccccata gacagctgct atactggcaa tggggtctta aaactgataa tcagaaaaca
     3961 agcaagagct tcttggaagg aactggagtg ttagggaaca cagacctggg aagagaggag
     4021 ccctgctgca gctgctgctg ctgcaatccc aacatgtgag aggctgaaac aggaaggctg
     4081 tccatttgag gttaagttgt gatacacagc aagtcaagag cctctctctg cttctgcctc
     4141 tctccctctt tgtgtatctg tctgtttctt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4201 gtgtgtgtgt gtgtgtgtgt tgttgattgg ttttggactt tttccccttg gggagactcc
     4261 aataccgatt tctgtggtga ttacacacac attcccagta gcaatgtaga agaacgtttt
     4321 cagctatgct cacgccttta atcacagcac tcaggaggca gaagaaagca gatgtctgag
     4381 tttgagccag cctggtctac agagtgagta aattccagga tacccagggc tatcaaacaa
     4441 acatttcttg tcactcaggg tcttggtgac agtcatttct cctggggtga gatggcattt
     4501 caatgtattt ttcaatttgc atttccattg tggccaggtg tgttgaatat tttttccaat
     4561 atctattaac aattcttttt ttattattat taaatttact taatttctat tttttattca
     4621 tttattatat ataagtacac tgtagctgtc ttcacataca ccagaagagg gtaacagatc
     4681 tctttacaga tggctgtgag ccaccatgtg gttgctggga attgaactca ggacctctgg
     4741 aagagcagtc gggtctctta accactgagc cgtctctcca gcccctatta acaattctta
     4801 tctcttcttt tgggaagtat ctgaccaatt catttgtcca tgtattgacc aacgatctgg
     4861 tattgggaat ttaaatactg gagttccttg tataatatac ataattccat tagataattt
     4921 tttttttggt tctttttttc ggagctgggg accgaaccca gggccttgca cttcctaggc
     4981 aagcgctcta ccactgagct aaatccccaa ccccctccat tagataatta actggtcaaa
     5041 ttttctccca ttctgattgc cccacacaca tgtagagacg aaaggttgaa ctctccgtgg
     5101 ttgtcagttt gccttgtctt gttttgtttt ggagacagaa tttcactagt tctgactggc
     5161 ctgaaacttg ctaggtaaac caggctggcc tcaaactcac cgagatatcc ccctgcctct
     5221 gcctcctaag tgctgagact aagacaagtg ctaccatgcc catccaccct actttttctt
     5281 ttattaaata tttgcttatt ttcttgtg
//
LOCUS       NM_001436661            1093 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 3, mRNA.
ACCESSION   NM_001436661
VERSION     NM_001436661.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1093)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1093)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 1093)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74640.1,
                                           SRR26360186.619255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000016.1  43955943-43956211   c
            270-399             JAXUCZ010000016.1  43955091-43955220   c
            400-518             JAXUCZ010000016.1  43954509-43954627   c
            519-739             JAXUCZ010000016.1  43954179-43954399   c
            740-856             JAXUCZ010000016.1  43950649-43950765   c
            857-1093            JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1093
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..269
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1005
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 3"
                     /protein_id="NP_001423590.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MLPGAEARQDQVIQPLLPRDFSNGYLVAEIFCIYYPWDLRLSSF
                     ENGTSLKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQE
                     IRSIQDDFANFTDYSYQMRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLF
                     LLQMLQRKLSRKLNPGWFDIKPTVGEITVGHLPAHSYKHKYKSKVSKERAVSSLSKSG
                     NDVQPHREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSCH"
     misc_feature    262..486
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     misc_feature    262..486
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     exon            270..399
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..518
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..739
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..856
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1093
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac caggtgctga agccagacag
      241 gaccaagtga ttcagcctct cctccccagg gatttttcaa atggctacct agttgcagag
      301 atattctgta tatattaccc ctgggacctt cgattatcat cctttgaaaa tggtacttcc
      361 ttgaaagtca aattggataa ctgggcacaa atagagaagt ttctagcgaa aaaaaaattt
      421 aaactaccta aagaactcat ccatggaaca attcactgta aggctggggt gcctgaaata
      481 ctgattcagg agatttacac tttactcacc catcaagaaa ttagaagcat ccaggatgat
      541 tttgctaatt tcacagacta tagttatcag atgcgtttgc ccctggttcc caggagtaca
      601 gtatcaaagt ctattaaaaa taacattagg ttatcggaac tactaagcaa tcctaatatt
      661 ctcagcaatg aactcaagat agaattcctc ttccttttgc aaatgctgca aagaaaatta
      721 agcagaaaat tgaatccagg gtggtttgat atcaaaccaa cagtgggaga aatcacagtt
      781 ggccatcttc ctgcccatag ctataagcac aaatacaaat caaaagtttc aaaggaaaga
      841 gctgtgtcgt ctttatcaaa atcaggcaat gatgtccaac cacatagaga aatccatgtg
      901 aagcaaaatg gaaaaccttg tgatgccact gcaaaaccta tgataaatgt ggaagaaaca
      961 atgaaagaca cggaggaagt agctttgaag aagtcatgtc attaatgtct accacaatct
     1021 gggtatataa tgacacaccc agtcttggat gtatttaaat aataaataac ttaacttggt
     1081 gtcttaacca taa
//
LOCUS       NM_001436663             963 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 5, mRNA.
ACCESSION   NM_001436663
VERSION     NM_001436663.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.694718.1,
                                           SRR26360181.3359500.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000016.1  43955943-43956211   c
            270-388             JAXUCZ010000016.1  43954509-43954627   c
            389-609             JAXUCZ010000016.1  43954179-43954399   c
            610-726             JAXUCZ010000016.1  43950649-43950765   c
            727-963             JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..963
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..269
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="upstream in-frame stop codon"
     exon            270..388
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..609
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..875
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 5"
                     /protein_id="NP_001423592.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQ
                     MLQRKLSRKLNPGWFDIKPTVGEITVGHLPAHSYKHKYKSKVSKERAVSSLSKSGNDV
                     QPHREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSCH"
     exon            610..726
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..963
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac caggtgctga agccagacag
      241 gaccaagtga ttcagcctct cctccccagt ttctagcgaa aaaaaaattt aaactaccta
      301 aagaactcat ccatggaaca attcactgta aggctggggt gcctgaaata ctgattcagg
      361 agatttacac tttactcacc catcaagaaa ttagaagcat ccaggatgat tttgctaatt
      421 tcacagacta tagttatcag atgcgtttgc ccctggttcc caggagtaca gtatcaaagt
      481 ctattaaaaa taacattagg ttatcggaac tactaagcaa tcctaatatt ctcagcaatg
      541 aactcaagat agaattcctc ttccttttgc aaatgctgca aagaaaatta agcagaaaat
      601 tgaatccagg gtggtttgat atcaaaccaa cagtgggaga aatcacagtt ggccatcttc
      661 ctgcccatag ctataagcac aaatacaaat caaaagtttc aaaggaaaga gctgtgtcgt
      721 ctttatcaaa atcaggcaat gatgtccaac cacatagaga aatccatgtg aagcaaaatg
      781 gaaaaccttg tgatgccact gcaaaaccta tgataaatgt ggaagaaaca atgaaagaca
      841 cggaggaagt agctttgaag aagtcatgtc attaatgtct accacaatct gggtatataa
      901 tgacacaccc agtcttggat gtatttaaat aataaataac ttaacttggt gtcttaacca
      961 taa
//
LOCUS       NM_001436697            3090 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 4, mRNA.
ACCESSION   NM_001436697 XM_006238646
VERSION     NM_001436697.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3090)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 3090)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 3090)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 3090)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 3090)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 3090)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 3090)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 3090)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3090)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 3090)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238646.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29380.1,
                                           SRR26360181.720552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000005.1  135319570-135319609 c
            41-138              JAXUCZ010000005.1  135319012-135319109 c
            139-186             JAXUCZ010000005.1  135314949-135314996 c
            187-297             JAXUCZ010000005.1  135311284-135311394 c
            298-378             JAXUCZ010000005.1  135306753-135306833 c
            379-488             JAXUCZ010000005.1  135304577-135304686 c
            489-1469            JAXUCZ010000005.1  135302980-135303960 c
            1470-1549           JAXUCZ010000005.1  135298279-135298358 c
            1550-1635           JAXUCZ010000005.1  135297655-135297740 c
            1636-1709           JAXUCZ010000005.1  135297473-135297546 c
            1710-1898           JAXUCZ010000005.1  135296880-135297068 c
            1899-2065           JAXUCZ010000005.1  135296609-135296775 c
            2066-2122           JAXUCZ010000005.1  135296062-135296118 c
            2123-2200           JAXUCZ010000005.1  135295896-135295973 c
            2201-2329           JAXUCZ010000005.1  135295084-135295212 c
            2330-3090           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..3090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3090
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..40
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            41..138
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2410
                     /gene="Nasp"
                     /note="isoform a is encoded by transcript variant 4;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform a"
                     /protein_id="NP_001423626.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAE
                     GQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIP
                     GLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETS
                     EDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLS
                     GQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSE
                     TKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANE
                     ETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWD
                     MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEA
                     HDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYE
                     KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMI
                     ASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSG
                     NEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     misc_feature    83..85
                     /gene="Nasp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    176..178
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    206..307
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    422..802
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    425..460
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    446..448
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    458..460
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    <467..1597
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <467..1597
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    584..586
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    602..604
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    641..643
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    707..805
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    800..802
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    803..805
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    830..832
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    845..946
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    935..937
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    995..997
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1040..1042
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1112..1570
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1214..1216
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1235..1237
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1448..1579
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    1472..1474
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1481..1483
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1523..1525
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1532..1534
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1574..1645
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1574..1645
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1661..1891
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1661..1891
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1667..1780
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1667..1780
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1667..1768
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    1667..1753
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1667..1753
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1670..1672,1679..1684,1691..1696,1700..1702,
                     1796..1798,1805..1810,1817..1822,1826..1831,1892..1894,
                     1901..1906,1913..1915)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1670..1672,1679..1684,1691..1696,1700..1702,
                     1796..1798,1805..1810,1817..1822,1826..1831,1892..1894,
                     1901..1906,1913..1915)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1766..1882
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1766..1882
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1793..1894
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    2027..2029
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2090..2092
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2132..2407
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2156..2158
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2159..2161
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2189..2209
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    2219..2221
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2276..2278
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2294..2296
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2309..2311
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     exon            139..186
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            187..297
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            298..378
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            379..488
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            489..1469
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1549
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1635
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1709
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1898
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2065
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2122
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2200
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2329
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..3090
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagactgaga gggcataggg aagacctgtc accttctcgg gcagtatact gcccactggc
       61 ccaccacctc aggggaacga tggccacaga gtctacagcc actgctgcca tcgccgcgga
      121 actggtttcc gctgacaaag ttgaagatgc tcctgctcct tctacctctg cagataaaat
      181 ggagagtctg gatgtggata gtgaagctaa gaaactactg ggattaggac agaaacatct
      241 ggtgatgggt gacattccag cagctgttaa tgcattccaa gaagcagcta gtcttttagg
      301 taagaagtat ggagaaacgg ctaatgagtg tggagaagcc ttcttttttt atgggaagtc
      361 acttctggag ttggccagaa tggagaatgg agtgttggga aatgccttag aaggagtgca
      421 tgtagaagag gaagaaggag aaaaaacaga agatgaatct ttggtagaaa ataatgataa
      481 tgtagatgag gaagcaaggg aagagttgag agaacaggtt tatgacgcca tgggagaaaa
      541 agaagccaaa aaagcagaag gccagtctct gacaaagcct gaaactgata aagaacagga
      601 aagtgaagtg gagaagggtg gaagagaaga tatggatata agtgagcctg cagagaagct
      661 ccaggaaaaa gttgaatcga cttcaaagca gttaactgaa tcctctgaag aggcaaaaga
      721 agcagcaata ccaggactga atgaagatga ggtcacttct gggaagacag aacaggaatc
      781 attgtgtact gaggaaggaa aatccatttc tggagtttat gttcaaaata aagaattcag
      841 agaagcagtg cctcaggagg agggagagga aatgataagc ttagaaaaaa agccaaaaga
      901 aacttcagaa gatcagacta ttggggctcc agaaaagcag gacactttaa tgaaggtggt
      961 agaaatagaa gctgaaatag actctgaagt caagtcagtg gatgtgggtg gggaggagcc
     1021 gaaggatcag ggagctatct ctgagagtga actaggaaag gctgttctta tgcaactctc
     1081 agggcaagat gttgaagtat caccagtagt ggctgcagag gctggatcag aagtctctga
     1141 gaagccaggg caggagatta cagttcttcc caacaatggt ccagttgttg gacaatcatc
     1201 tgcaggagat caaactccta gtgaaccaca gaattctgca gaaagactgt cagaaactaa
     1261 agatggcgca agtgtagagg aggtcaaggc agagctggtt cctgaacagg aggaagctat
     1321 gcctcctgta gaagagtctg aggcagctgg agatggggtt gagaccaagg tagcccagag
     1381 ggccacggag aaagcacctg aagacaaatt taagatagct gctaatgaag agacacaaga
     1441 gagagacgaa cagatgaaag agggtgaaga aactgaaggc tcagaggaag aagacaaaga
     1501 aaatgacaag gctgaagaaa caacaaatga atcagttctt gaaaaaaaga ctcttcaaga
     1561 aaatgaagaa gaggagattg ggaatttaga acttgcctgg gatatgctag atttagccaa
     1621 gattattttt aagaggcaag aaacaaaaga agcccagctt tatgctgcac aagcccatct
     1681 taaacttgga gaagttagtg ttgaatctga gaattatatc caagctgtgg aggagtttca
     1741 ggcttgccta agcctgcaag agcagtattt ggaagctcac gatcgtctcc ttgcggagac
     1801 tcactaccag ttgggtttgg cctatggtta caactctcag tatgatgagg ctgtagcaca
     1861 gtttggcaaa tctattgacg tcattgagaa gagaatggct gtactacttg agcagatgaa
     1921 ggaggctgaa ggatcattta ctgaatacga gaaagaaatc gaggagctga aagaactgct
     1981 ccccgagatt cgggagaaga tagaggatgc aaaggagtct cagcggagtg ggaatgtagc
     2041 tgagctggct ctgaaggcca ctctggtcga gagctctact tcaggtttca ctcctagtgg
     2101 agctggtgcc tcggtatcca tgattgccag tagaaaacca acagatggcg cttcctcatc
     2161 aaactgtgtc actgatattt ctcatcttgt cagaaagaag aggaaaccag aggaagagag
     2221 tccccggaaa gatgatgcaa agaaagctaa accagaacca gaggtgaatg gaggcagtgg
     2281 agatgctgtc tccagtggaa atgaagtttc agaaaacatg gaggcagagg ctgagaatca
     2341 ggctgagagc cagacaacag cagaagggac agtggactct gcagctacag ttaaaagcac
     2401 tgcatgttaa gaggcgagca gaaccttcct cctgagggaa agtggttttg tacataatgt
     2461 attttttcac ttttggggat tctttttgta taactccaat aaagattgta ggcaacagct
     2521 gagactttga tggctttttt cttaaaaata ttggtggatt gttttggggc actctatatt
     2581 gtgtatacat gccttgtgtt ttgctactgc acaacccact tcctgtctaa tgtggaggtg
     2641 atcaagttga tcaaggccct tcatctactg gtgctatgtt tctatttcca aatatttggc
     2701 tgaattcaaa taccttgtaa gctttccatg gtgctgtccc tggatggggt ctgctaaaca
     2761 agaactggta gaaatcagtt tggtgctgaa aatggagcat ggaatatgac ccaggtcttg
     2821 gtttgtgcct accttctgtt cacctggttt ccatttaagg ccataatatc ctgccctggc
     2881 aaaactggca gaaacatggg aaatgattcc tgaggaaaac tgttgttaga tactccgtag
     2941 gatcacactg tagtgggaga caagtagaag actatgattg agaagtctgt tacgttattt
     3001 tctgtataga aagattacaa tatgtcaata agtggaattg ttatattgtg cagttttgtc
     3061 tataaaaata aatatgctaa ttttaacaaa
//
LOCUS       NM_001436680            3739 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 268 (Tmem268), transcript
            variant 5, mRNA.
ACCESSION   NM_001436680 XM_017593255
VERSION     NM_001436680.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_017593255.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1700976.1,
                                           SRR26360194.2152557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000005.1  81991410-81991562
            154-237             JAXUCZ010000005.1  81993561-81993644
            238-427             JAXUCZ010000005.1  81995120-81995309
            428-537             JAXUCZ010000005.1  81998175-81998284
            538-645             JAXUCZ010000005.1  82002470-82002577
            646-795             JAXUCZ010000005.1  82003984-82004133
            796-906             JAXUCZ010000005.1  82008206-82008316
            907-987             JAXUCZ010000005.1  82010409-82010489
            988-1167            JAXUCZ010000005.1  82010883-82011062
            1168-3739           JAXUCZ010000005.1  82014399-82016970
FEATURES             Location/Qualifiers
     source          1..3739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3739
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
     exon            1..153
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            154..237
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            238..427
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    292..294
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="upstream in-frame stop codon"
     CDS             319..1347
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001423609.1"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
                     /translation="MACEPPSDPGGAAGPLPTSTLGCSTLPQGNPPGWGEELHNGQVL
                     SVLRIDNTCAPISFDLRVAEEQLQAWGIQVPAEQYRSLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAVSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVERPEDLEDSPLLPRTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSQLPQPMGTRHMDSARIPCPCQLIEVHILGT
                     GCCPFLAR"
     misc_feature    433..1302
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     misc_feature    433..1302
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     exon            428..537
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            538..645
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            646..795
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            796..906
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            907..987
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1167
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..3739
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgtcc ctccgctaag gctcgggtga tcttttcccg ccccacgcgt caggcgtggg
       61 atctgcaggg cagggcgggt gatttctggg gtgaaggaac cctaaggcca gagggcagag
      121 acccgggagc cagctgccta aggccgaggc caggtcatcc cagcctcgtg taactgctcc
      181 tgttgaagcc ttgagctaca cagcgaagag gccagaaggc tcagtgcctc cctgaaggca
      241 agtggaggtg agacgctgcc cggtgtgaac tgcaccccta gaaacaggaa gtagaagcta
      301 gaccgctgtc tgtctgccat ggcttgtgaa cctccctcag atcctggtgg ggcagctggt
      361 cctctgccca cctccaccct gggctgcagc accctgcctc aggggaaccc tcctggctgg
      421 ggggaagagc tacacaatgg ccaggtcctc tcagtcctcc ggatcgacaa cacctgtgca
      481 cccatctcct ttgacctgag agttgcagaa gaacagctgc aggcctgggg cattcaggtc
      541 cctgctgagc agtataggag cttggctgag agtgcgcttt tggagcctca agtgaggagg
      601 tacatcatct acaactccag gcccatgagg ctggcctttg ctgtggtgtt ctatgtgttg
      661 gtgtgggcca acatctactc caccagccaa atgtttgccc taggcaacca gtgggcaggt
      721 gtgctgcttg cgaccctggc cgctgtcagc ctgaccctga ctcttgtgct ggtctttgag
      781 aggcagcaga ggaaggctaa cactaacaca gacctgaggc tggtggctgc caatggagcc
      841 cttctgagac accgagtgct gctgggggtg acagataccg tggagggatg ccagagtgtg
      901 atacagctct ggtttgtcta ctttgacctg gagaactgtg tgcagttctt gtccgatcat
      961 gtccaagaaa tgaagaggag tcaggagtcc ttgctgagaa gcagattaag ccagctatgt
     1021 gttgtcatgg agactggagt gagccccgtg gtggaaaggc ctgaggactt ggaagattct
     1081 cccctcctgc ccagaactcc tggtcctcag gagagaccac tcacacagac tgaactctat
     1141 cagcttgttc cagaggctga gccagaggag atggcccggc aactgctggc agtgtttggt
     1201 ggctactaca cccggctcct ggtgacctct cagctccctc agccaatggg aacacgacac
     1261 atggactctg caaggatccc atgcccctgc cagctcatag aagtacacat tttgggcaca
     1321 ggatgttgcc cattcctggc caggtgacct agggatgaag gtgttcatct tcctccaaga
     1381 ctaagaagta ggggaggagt caggagccca gcatggccac cagtgagctc agatgaggtc
     1441 agcgtttgga gacactttct caagtgtcag tcatgtaggc ctttgggtca tcaagtgcac
     1501 accagatgtc ttcttggcat catactctgt cctggccttg ctgaatctgg tggctgagct
     1561 ggtggctggc cttgcagcct ggatggagga tactgtctgt tgcctgtcaa ggcctaggga
     1621 cctgcagctg actccacagg gcaagtgcct gaccctgggg tcagaaagtg agaccaaggc
     1681 tccaaggaga cgcccatctt tcagcggtgc ctcagtctgc cggtcacaac ctacctgccc
     1741 tcaatgtgag ggaagattct tggaagggtg agctagcttg tgagtgacag taccgtctgg
     1801 gattgttgtc tgttagcacc aaggttagag agggctaggg ttggaggatg ggtgaggaga
     1861 caaaagcctg gcagatgacc atcaacaagg ggcactggaa aagaagctcc tgttatactc
     1921 agtgactttg cactggcttg ctgcttgtga atgtgtttct cttctgccaa gcagcagtgg
     1981 tgttttctga cactaacatt gttctggaat gaggtatgat tagacactct gggtttatgt
     2041 gaagaactca gcgactttcc caaagttgga agactgtcta cagccctatg cccagagccc
     2101 tggactcgtg taaaggtcct gctccatgaa ccagcctttg tggtttttgt cctccacaaa
     2161 tcatcattat aagttggaac tcttcctgga actggctggc atatgcattc attcctgttg
     2221 gactcttatt catccttcaa aaccctactt ttcatatcct tcctgctgct ttctgtctca
     2281 ctgaaattct gatggaactg ccccccttat ggatgtttta tgttattcag tgtttctcct
     2341 gtacatacct ctttttctat caagactgta aactcctcaa ggtccaacac tgcacccacc
     2401 ttccttttgg gaatgacttg gacttgttta gaaaaaaaaa acaattttga aaagtcccat
     2461 ggattggtcg ccttgccctc tccacccatt gtggcaaatg cttctggaag acatggttga
     2521 atggtaaggc ccaggtcgtg atggaccaga ggtctggtct gcagctgtgt cactctattt
     2581 gtgcaccctc tgtttgccca tctctacagc tggatgattt tggtgatttc cagcttgtgc
     2641 tgtttgttat tcttacctcc gtgcacaaag tgctctcctg cccccaaact gaggggtcct
     2701 tggtggggac tgacctaaaa tagtaacctg gattcttgtt gcacacctgc cacatccagg
     2761 gctgcgtgac catggctgag tgcactgctt ctctgtgtgt ccaatgattc ctttatagat
     2821 tgatgcagtg aaccacagtg gcacagctca ggagattttc tgggtgagac atgccctact
     2881 tccttgcatt ctttgtgtcc aagatggagg agtcccccag ccatgtgtca tggcagcttt
     2941 gctcagtgca gttattcact gtcttttgag ccacagaaaa tgtcactgtg aagttgatca
     3001 agggaagcct gtgcttgtcc tctgttcaca gactcttgag catgatggtg gaaactaaaa
     3061 ctgtttggtg agtgagagag ttgctcatgg aggcttggta tggtccttcc acagttttcc
     3121 tgcctgccgg atgggactta tggggtgagc ccacagtaga ccttctttgt gtgtgcctcg
     3181 gtttcctcat ttgtaaaatc cacgtgtctc acctgcttca caaagtcgtc atgaggatga
     3241 gccatccagc cttttttttt tttttttttt tgaaaaaata tctttaatcc tatccctgtg
     3301 caggtgaggt ctgggagtta aactgaggtc ctcagtaaga gtggtttatg cccttacttc
     3361 agcaccatct ctacagccga gtgctcctaa gtcttaaggc tcaataccca taagaggcag
     3421 gaaccatgga caaaccgcca tgcaggtagg aacagtcaaa gccaagtcct gcctgccatc
     3481 ttgtctctgt cccttcagac accggggagg aaagcacatc ctccagatgt ttcaacctga
     3541 atagcaacaa ccttcagtgc ttgcaacacc aaagctgtca caaagccgga gcaggaactc
     3601 cataacctgt cgccatttct catttattct tgttgtctgg tatacagtag gtgctcatat
     3661 gtgtttgact cttgcctcat gctcaattat tccagtacct cagggttatg tatgcaaata
     3721 aagatttatc aaatctcaa
//
LOCUS       NM_001436713            5184 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 3 receptor (Csf3r),
            transcript variant 2, mRNA.
ACCESSION   NM_001436713 XM_063287438
VERSION     NM_001436713.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5184)
  AUTHORS   Zhang,E., Lee,S., Yi,M.H., Nan,Y., Xu,Y., Shin,N., Ko,Y., Lee,Y.H.,
            Lee,W. and Kim,D.W.
  TITLE     Expression of granulocyte colony-stimulating factor 3 receptor in
            the spinal dorsal horn following spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Mol Med Rep 16 (2), 2009-2015 (2017)
   PUBMED   28656207
  REMARK    GeneRIF: the expression of GCSFR in neurons following peripheral
            nerve injury may be involved in the induction and maintenance of
            neuropathic pain through the STAT3 and TRPV1 signaling pathway.
REFERENCE   2  (bases 1 to 5184)
  AUTHORS   Aref,S., El-Ghonemy,M., Abouzeid,T., El-Sabbagh,A. and El-Baiomy,M.
  TITLE     Prevalence and impact of colony stimulating factor 3 receptor
            (CSF3R) mutations among Egyptian acute myeloid leukemia patients
  JOURNAL   Leuk Res 38 (6), 722-725 (2014)
   PUBMED   24746896
REFERENCE   3  (bases 1 to 5184)
  AUTHORS   Fleischman,A.G., Maxson,J.E., Luty,S.B., Agarwal,A., Royer,L.R.,
            Abel,M.L., MacManiman,J.D., Loriaux,M.M., Druker,B.J. and
            Tyner,J.W.
  TITLE     The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in
            mice that is responsive to therapeutic JAK inhibition
  JOURNAL   Blood 122 (22), 3628-3631 (2013)
   PUBMED   24081659
REFERENCE   4  (bases 1 to 5184)
  AUTHORS   Kosmider,O., Itzykson,R., Chesnais,V., Lasho,T., Laborde,R.,
            Knudson,R., Gauthier,A., Merlevede,J., Ades,L., Morabito,M.,
            Fontenay,M., Tefferi,A., Droin,N. and Solary,E.
  TITLE     Mutation of the colony-stimulating factor-3 receptor gene is a rare
            event with poor prognosis in chronic myelomonocytic leukemia
  JOURNAL   Leukemia 27 (9), 1946-1949 (2013)
   PUBMED   23774674
REFERENCE   5  (bases 1 to 5184)
  AUTHORS   Hanumanthu,V.S. and Pirruccello,S.J.
  TITLE     GCSF-R expression in myelodysplastic and myeloproliferative
            disorders and blast dysmaturation in CML
  JOURNAL   Am J Clin Pathol 140 (2), 155-164 (2013)
   PUBMED   23897249
REFERENCE   6  (bases 1 to 5184)
  AUTHORS   Semerad,C.L., Poursine-Laurent,J., Liu,F. and Link,D.C.
  TITLE     A role for G-CSF receptor signaling in the regulation of
            hematopoietic cell function but not lineage commitment or
            differentiation
  JOURNAL   Immunity 11 (2), 153-161 (1999)
   PUBMED   10485650
REFERENCE   7  (bases 1 to 5184)
  AUTHORS   Otsuji,W., Tanase,S., Yoshida,S. and Bawden,J.W.
  TITLE     The immunohistochemical localization of the interferon-gamma and
            granulocyte colony-stimulating factor receptors during early
            amelogenesis in rat molars
  JOURNAL   Arch Oral Biol 44 (2), 173-181 (1999)
   PUBMED   10206335
REFERENCE   8  (bases 1 to 5184)
  AUTHORS   Hermans,M.H., Ward,A.C., Antonissen,C., Karis,A., Lowenberg,B. and
            Touw,I.P.
  TITLE     Perturbed granulopoiesis in mice with a targeted mutation in the
            granulocyte colony-stimulating factor receptor gene associated with
            severe chronic neutropenia
  JOURNAL   Blood 92 (1), 32-39 (1998)
   PUBMED   9639496
REFERENCE   9  (bases 1 to 5184)
  AUTHORS   Dong,F., Dale,D.C., Bonilla,M.A., Freedman,M., Fasth,A.,
            Neijens,H.J., Palmblad,J., Briars,G.L., Carlsson,G., Veerman,A.J.,
            Welte,K., Lowenberg,B. and Touw,I.P.
  TITLE     Mutations in the granulocyte colony-stimulating factor receptor
            gene in patients with severe congenital neutropenia
  JOURNAL   Leukemia 11 (1), 120-125 (1997)
   PUBMED   9001427
REFERENCE   10 (bases 1 to 5184)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287438.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7666.1,
                                           SRR26360194.4951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JAXUCZ010000005.1  143583210-143583447
            239-322             JAXUCZ010000005.1  143586042-143586125
            323-622             JAXUCZ010000005.1  143588148-143588447
            623-746             JAXUCZ010000005.1  143590265-143590388
            747-934             JAXUCZ010000005.1  143590587-143590774
            935-1104            JAXUCZ010000005.1  143592025-143592194
            1105-1258           JAXUCZ010000005.1  143592279-143592432
            1259-1338           JAXUCZ010000005.1  143593262-143593341
            1339-1552           JAXUCZ010000005.1  143593661-143593874
            1553-1735           JAXUCZ010000005.1  143594985-143595167
            1736-1837           JAXUCZ010000005.1  143595483-143595584
            1838-1984           JAXUCZ010000005.1  143597332-143597478
            1985-2125           JAXUCZ010000005.1  143597586-143597726
            2126-2216           JAXUCZ010000005.1  143600615-143600705
            2217-2298           JAXUCZ010000005.1  143600867-143600948
            2299-5184           JAXUCZ010000005.1  143601497-143604382
FEATURES             Location/Qualifiers
     source          1..5184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5184
                     /gene="Csf3r"
                     /note="colony stimulating factor 3 receptor"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
     exon            1..238
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    184..186
                     /gene="Csf3r"
                     /note="upstream in-frame stop codon"
     exon            239..322
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2775
                     /gene="Csf3r"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; granulocyte colony-stimulating factor receptor;
                     colony stimulating factor 3 receptor (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     isoform a precursor"
                     /protein_id="NP_001423642.1"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
                     /translation="MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLA
                     SCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFC
                     LVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKL
                     CIDPMDVVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQECELRYQPQLE
                     GANWTLVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWSPGLQLRPTIKA
                     PTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCPDGQGRIMHLCN
                     TTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLHAMAQDLGSIWV
                     DWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHPFQLYRITVAPL
                     YPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIF
                     WTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNSTGLTLMTMALDS
                     SDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLSAWVPTIMTEET
                     FQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAYVLQGDPREISN
                     QFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPKSYENIWFHSRP
                     QETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     sig_peptide     259..333
                     /gene="Csf3r"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    328..591
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    328..591
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    625..921
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    625..921
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    1555..1821
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1555..1821
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1795..1800,1804..1809)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1795..1800,1804..1809)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1843..1845,2035..2037,2080..2082)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1843..1845,2035..2037,2080..2082)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    1852..2085
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1852..2085
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     exon            323..622
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            623..746
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            747..934
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1104
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1258
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1338
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1552
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1735
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1837
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1984
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2125
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2216
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2298
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..5184
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggagag gagacaagag aagagagagc aaacgtgggg gctgggcaca gcgccccagc
       61 cccaatgtaa gtagggggag ggcggagccc tgaaggcctc agaccattcc ccagccctga
      121 cagggtcaca tcagggggcc caagacaggg gatccttcgg aaatggaagg ctctctgtgt
      181 gtatagcatc aggaaagtca gacagctgga tctctttggg aacaggagct gagctcaggt
      241 aaacaccaag ctggcgaaat ggtggggctg ggagcctgca acctgactgg agttaccctg
      301 attgtcttgc tactccccag aagtctggag ggctgcgggc aaatcaggat ctcacccccc
      361 attgtccatc ttggggatcc tgtcctggcc tcctgcacca tcagcccaaa ctgcagcaaa
      421 ctggaccgac agccaaagat cctatggaga ctgcaagatg aaccaaacca gcctggggac
      481 agacagcatc acctgcctga cgggtcccag gagtccatca tcactctgcc tcatctgaac
      541 tacactcagg ccttcctctt ctgcttggtg ccatggaaca acagcttcca ggtcctggat
      601 caagctgagc ttcgtgcagg ctatcctcct gccagcccct ccaacctatc ctgcctcatg
      661 tacctcacca ccaacagcct ggtctgccag tgggagccag gccccgagac ccacctgccc
      721 actagcttca tcctaaagag cttcaggagc cgcaccggct gtcagtacca ggggggcacc
      781 atcctggact gtatgcccaa gaagagacac agcaactgct ccatcccccg caaacacttg
      841 cttctgtacc agaatatggt catctgggtg caagcggaga atatgctagg gtccagcgag
      901 tccccaaagc tgtgcattga ccccatggat gttgtgaaat tggagcctcc catgctgcag
      961 gccctggaca ttggccatga tatagtctct cgccagcctg gctgcctatg gctgagctgg
     1021 aagccatgga agcccagtga gttcatggag caggagtgtg aactccgtta ccagccacag
     1081 cttgaaggag ccaactggac cctggtgtcc cacctgcctt ccagcacgga ccggttcgag
     1141 ctctgcagcc ttcatcaagc cccagtctac accctacagt tgcgatgcat ccgctcatct
     1201 ctgcctggac tctggagcag ctggagccct ggccttcagc tgaggcccac cattaaggcc
     1261 cccaccatca gactggacac atggtggcag aagaagcatc tggatcctga gacagtgaga
     1321 atgcagctgt tctggaagcc aacacccctg cagaaagaca gtggacagat ccagggctac
     1381 ctgctctcct ggagttgccc agatgggcaa gggcggatca tgcacctctg taacaccaca
     1441 gagctcagct gcaccttcca cctgccctca gaggcccaga acgtgaccct tgtggcctac
     1501 aactcggcgg ggacctcctc ccctactctg gtggttttcc tggagcacga aggtccagct
     1561 gtgaccagcc tgcatgccat ggcccaagac cttggtagca tctgggtaga ctgggaagcc
     1621 cccagccttc tgcctcaggg ctatctcatt gagtggggcc cggattccca caaatacagc
     1681 aataattcct ggaggataga gcccaatggg aacaccactg gaattctgtt agaggacaat
     1741 atacatccct ttcaactcta cagaatcaca gtggctcccc tgtacccagg caccgtggga
     1801 ccccctgtaa atgtctacac ctactctgga gagaaagccc ttcctcatgc tccagagcta
     1861 tatctaaagc atgttggcag gacctgggca cagttggagt gggtacctga gaccccttgg
     1921 ctggggatga tacccctcac caactacacc atcttctgga ccgatgctcg ggaccactcc
     1981 ttctctgtca ccctgaacat ctcctttcat gactttgtcc tggaccacct gaaacctgcc
     2041 agtttgtatc acgtctacct catggccacc agccgggcag ggtccaccaa cagtacaggc
     2101 cttaccctga tgaccatggc cctagattca tctgatgtaa acattttcct gggcatactt
     2161 tgcttcgtac ttttgtccat tacctgtgca actgcctggt tctgctgcaa gcaaagcaga
     2221 aagactttct tctggccaaa tgtgccagac ccagcccaca gcagtctgag cgcctgggtg
     2281 cccaccatca tgacagagga aaccttccag ctgcccagct tctggggctc cagtgtgccg
     2341 tcaatcacca agatcactga actggaggag gacaagaaac cgacccactg ggatcccagt
     2401 gagagctctg ggactgggag ccttccagcc gtggttcagg cttacgtgct ccaaggagac
     2461 ccaagagaaa tttccaacca gttccagcct ccctctagca ctaatgacca ggttctctat
     2521 ggtcaggtgc ttgggagccc caccagccca gaagtagtgg gataccttcg gtgtgactcc
     2581 actcagcccc tcttgggagg ccccacaccc agccctaaat cctatgaaaa catctggttc
     2641 cattcaagac cccaggagac ctttataccc caacctccaa gccaggaaga tgactgtgtc
     2701 tttggacctc catttgattt ccccctcttc caggggctcc aggtccatgg agttgaagaa
     2761 caagggggtt tctaggactt ttggggtcct tacatcctga aggccctggc ctattcagga
     2821 aagatcccac cactaatatc tactggtcct gagggaaaca gaaaggccct atttgtctcc
     2881 agctgtggcc cctaggacct ctccttcact ctaacctcca caggctacac ccctaggtct
     2941 ttctcacact ccaaggtcca gatacatact gtttacagcc cactagtcac cttgtgtctc
     3001 tcatataatt tcagtccgtt aaactgagtg taggttttga gcagggacta gcacgttcac
     3061 aaatcctggc tggacgtagt gatacatgcc tagcatccca actcaaacgt ttgggaggaa
     3121 gatgcaggag gattgcaagt tccaggccag cctgggctat atgaagagat cctgcctcag
     3181 aaattaagca aaagccaaat aaaatttttt tattacattt actttttgtt ggtggggttg
     3241 ggggctcaca ggcaaaggtc agacacctta agggaattaa ctctggcctc cagcctgtgg
     3301 attttgggag gtgaacgtaa ggtttagtgg caagcatctt tccccaggga ggcatttcac
     3361 tagtcccaga gaggagtctc ttaagtatag ctaagtgtct tttacacttg tctgtctgtc
     3421 tgtttttcaa aaaaaggttt ctctgtgtac ctgtcctatc tgtcctggaa ctcactctgt
     3481 agaacaggct ggcctcaaac tcagagatcc acctgcctct gtcttctgaa tggtgggaat
     3541 aaaggcctgc acaccaccac ccagcagtgt catttcctct cagggcccag cagtcatgaa
     3601 gctatttctc agtcagtcat ctgttccgtt ccttccctcc tcttcctcct tccttccttc
     3661 cctcccttcc tctttccttc cttccttcct tccctccctc cctccctccc tccttccttc
     3721 cttccttcct tccttccttc cgtcctcttg cctagcatct aagattcaaa agagacaacc
     3781 cccatagaca gctgctatac tggcaatggg gtcttaaaac tgataatcag aaaacaagca
     3841 agagcttctt ggaaggaact ggagtgttag ggaacacaga cctgggaaga gaggagccct
     3901 gctgcagctg ctgctgctgc aatcccaaca tgtgagaggc tgaaacagga aggctgtcca
     3961 tttgaggtta agttgtgata cacagcaagt caagagcctc tctctgcttc tgcctctctc
     4021 cctctttgtg tatctgtctg tttcttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4081 gtgtgtgtgt gtgtgttgtt gattggtttt ggactttttc cccttgggga gactccaata
     4141 ccgatttctg tggtgattac acacacattc ccagtagcaa tgtagaagaa cgttttcagc
     4201 tatgctcacg cctttaatca cagcactcag gaggcagaag aaagcagatg tctgagtttg
     4261 agccagcctg gtctacagag tgagtaaatt ccaggatacc cagggctatc aaacaaacat
     4321 ttcttgtcac tcagggtctt ggtgacagtc atttctcctg gggtgagatg gcatttcaat
     4381 gtatttttca atttgcattt ccattgtggc caggtgtgtt gaatattttt tccaatatct
     4441 attaacaatt ctttttttat tattattaaa tttacttaat ttctattttt tattcattta
     4501 ttatatataa gtacactgta gctgtcttca catacaccag aagagggtaa cagatctctt
     4561 tacagatggc tgtgagccac catgtggttg ctgggaattg aactcaggac ctctggaaga
     4621 gcagtcgggt ctcttaacca ctgagccgtc tctccagccc ctattaacaa ttcttatctc
     4681 ttcttttggg aagtatctga ccaattcatt tgtccatgta ttgaccaacg atctggtatt
     4741 gggaatttaa atactggagt tccttgtata atatacataa ttccattaga taattttttt
     4801 tttggttctt tttttcggag ctggggaccg aacccagggc cttgcacttc ctaggcaagc
     4861 gctctaccac tgagctaaat ccccaacccc ctccattaga taattaactg gtcaaatttt
     4921 ctcccattct gattgcccca cacacatgta gagacgaaag gttgaactct ccgtggttgt
     4981 cagtttgcct tgtcttgttt tgttttggag acagaatttc actagttctg actggcctga
     5041 aacttgctag gtaaaccagg ctggcctcaa actcaccgag atatccccct gcctctgcct
     5101 cctaagtgct gagactaaga caagtgctac catgcccatc caccctactt tttcttttat
     5161 taaatatttg cttattttct tgtg
//
LOCUS       NM_001436678            4632 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 268 (Tmem268), transcript
            variant 3, mRNA.
ACCESSION   NM_001436678 XM_017593253
VERSION     NM_001436678.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_017593253.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1400923.1,
                                           SRR26643298.27566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1021              JAXUCZ010000005.1  81990314-81991334
            1022-1130           JAXUCZ010000005.1  81993536-81993644
            1131-1320           JAXUCZ010000005.1  81995120-81995309
            1321-1430           JAXUCZ010000005.1  81998175-81998284
            1431-1538           JAXUCZ010000005.1  82002470-82002577
            1539-1688           JAXUCZ010000005.1  82003984-82004133
            1689-1799           JAXUCZ010000005.1  82008206-82008316
            1800-1880           JAXUCZ010000005.1  82010409-82010489
            1881-2060           JAXUCZ010000005.1  82010883-82011062
            2061-4632           JAXUCZ010000005.1  82014399-82016970
FEATURES             Location/Qualifiers
     source          1..4632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..4632
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
     exon            1..1021
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1130
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1320
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1185..1187
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="upstream in-frame stop codon"
     CDS             1212..2240
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001423607.1"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
                     /translation="MACEPPSDPGGAAGPLPTSTLGCSTLPQGNPPGWGEELHNGQVL
                     SVLRIDNTCAPISFDLRVAEEQLQAWGIQVPAEQYRSLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAVSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVERPEDLEDSPLLPRTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSQLPQPMGTRHMDSARIPCPCQLIEVHILGT
                     GCCPFLAR"
     misc_feature    1326..2195
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     misc_feature    1326..2195
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     exon            1321..1430
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1538
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1688
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1799
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1880
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2060
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..4632
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgatcctca cttgtcccca ggggcacctg catgggatat gctaatttgg cttttcaatt
       61 ctttcttgct gctttgaaac atcctgcagg catatgtaag tcctgtggtc tggaagtcct
      121 caagagtttc atagtaactg ttgaacgaag aagtgtgtat gtgtttctct gtgtgtggaa
      181 gaccacttgt agagaggcct gtactgtcct agtccttcct gcaagcaagg gtgagaacca
      241 catatgcatc cgatcccctt aaaaagaaac aaggccattg gtgcagcaac taagtaccca
      301 gggtctttgt taaaagacag tgtttggtgg ctaatagaat ctgctccctt tatatataaa
      361 catgcactcg cggttagcca cgtctgttgg tgtcagacca accaaccaag gtgaacccaa
      421 gactagtgat tcacttggaa aaagaagcag accatcacag atcctcttaa atcttaagga
      481 gcagggtgaa caaatgtggg tttttgaaca cctcatacat tattttgttg aaatttcaca
      541 caatttcatg gcacagtcat aactagtttt aaagaaaacg cagacacaaa gtttaattta
      601 ccagacaatt aagaagtggg gactacaccg acgctttcaa tactgaacat cgtttttcat
      661 taaaaacaag cctagagaga aacttctggt cccgagtgtg cctcatgcat cagatcccat
      721 gactgtgtca ctcgggacag gcccccccac cccgctcctt cacggcaggg acgagcccag
      781 atctcatgca cgtggcgggc acagggctcc tactggcgcc ctgggggagc gtggctgatg
      841 aaacgctccg ggctcggcct gagagacgtg ccccctacgg ggtaattcgg cggaagagac
      901 cggctggggt ggcgcgcccg aagggcgtgc gggggcgacg ggggcggcgg cgcccggacg
      961 ccgcggcgca gaaagggcgt ggaacctttg accctgcgcg tccccgggcg gcagctaggc
     1021 ggaatcccca cactcccact ttgcaggtca tcccagcctc gtgtaactgc tcctgttgaa
     1081 gccttgagct acacagcgaa gaggccagaa ggctcagtgc ctccctgaag gcaagtggag
     1141 gtgagacgct gcccggtgtg aactgcaccc ctagaaacag gaagtagaag ctagaccgct
     1201 gtctgtctgc catggcttgt gaacctccct cagatcctgg tggggcagct ggtcctctgc
     1261 ccacctccac cctgggctgc agcaccctgc ctcaggggaa ccctcctggc tggggggaag
     1321 agctacacaa tggccaggtc ctctcagtcc tccggatcga caacacctgt gcacccatct
     1381 cctttgacct gagagttgca gaagaacagc tgcaggcctg gggcattcag gtccctgctg
     1441 agcagtatag gagcttggct gagagtgcgc ttttggagcc tcaagtgagg aggtacatca
     1501 tctacaactc caggcccatg aggctggcct ttgctgtggt gttctatgtg ttggtgtggg
     1561 ccaacatcta ctccaccagc caaatgtttg ccctaggcaa ccagtgggca ggtgtgctgc
     1621 ttgcgaccct ggccgctgtc agcctgaccc tgactcttgt gctggtcttt gagaggcagc
     1681 agaggaaggc taacactaac acagacctga ggctggtggc tgccaatgga gcccttctga
     1741 gacaccgagt gctgctgggg gtgacagata ccgtggaggg atgccagagt gtgatacagc
     1801 tctggtttgt ctactttgac ctggagaact gtgtgcagtt cttgtccgat catgtccaag
     1861 aaatgaagag gagtcaggag tccttgctga gaagcagatt aagccagcta tgtgttgtca
     1921 tggagactgg agtgagcccc gtggtggaaa ggcctgagga cttggaagat tctcccctcc
     1981 tgcccagaac tcctggtcct caggagagac cactcacaca gactgaactc tatcagcttg
     2041 ttccagaggc tgagccagag gagatggccc ggcaactgct ggcagtgttt ggtggctact
     2101 acacccggct cctggtgacc tctcagctcc ctcagccaat gggaacacga cacatggact
     2161 ctgcaaggat cccatgcccc tgccagctca tagaagtaca cattttgggc acaggatgtt
     2221 gcccattcct ggccaggtga cctagggatg aaggtgttca tcttcctcca agactaagaa
     2281 gtaggggagg agtcaggagc ccagcatggc caccagtgag ctcagatgag gtcagcgttt
     2341 ggagacactt tctcaagtgt cagtcatgta ggcctttggg tcatcaagtg cacaccagat
     2401 gtcttcttgg catcatactc tgtcctggcc ttgctgaatc tggtggctga gctggtggct
     2461 ggccttgcag cctggatgga ggatactgtc tgttgcctgt caaggcctag ggacctgcag
     2521 ctgactccac agggcaagtg cctgaccctg gggtcagaaa gtgagaccaa ggctccaagg
     2581 agacgcccat ctttcagcgg tgcctcagtc tgccggtcac aacctacctg ccctcaatgt
     2641 gagggaagat tcttggaagg gtgagctagc ttgtgagtga cagtaccgtc tgggattgtt
     2701 gtctgttagc accaaggtta gagagggcta gggttggagg atgggtgagg agacaaaagc
     2761 ctggcagatg accatcaaca aggggcactg gaaaagaagc tcctgttata ctcagtgact
     2821 ttgcactggc ttgctgcttg tgaatgtgtt tctcttctgc caagcagcag tggtgttttc
     2881 tgacactaac attgttctgg aatgaggtat gattagacac tctgggttta tgtgaagaac
     2941 tcagcgactt tcccaaagtt ggaagactgt ctacagccct atgcccagag ccctggactc
     3001 gtgtaaaggt cctgctccat gaaccagcct ttgtggtttt tgtcctccac aaatcatcat
     3061 tataagttgg aactcttcct ggaactggct ggcatatgca ttcattcctg ttggactctt
     3121 attcatcctt caaaacccta cttttcatat ccttcctgct gctttctgtc tcactgaaat
     3181 tctgatggaa ctgcccccct tatggatgtt ttatgttatt cagtgtttct cctgtacata
     3241 cctctttttc tatcaagact gtaaactcct caaggtccaa cactgcaccc accttccttt
     3301 tgggaatgac ttggacttgt ttagaaaaaa aaaacaattt tgaaaagtcc catggattgg
     3361 tcgccttgcc ctctccaccc attgtggcaa atgcttctgg aagacatggt tgaatggtaa
     3421 ggcccaggtc gtgatggacc agaggtctgg tctgcagctg tgtcactcta tttgtgcacc
     3481 ctctgtttgc ccatctctac agctggatga ttttggtgat ttccagcttg tgctgtttgt
     3541 tattcttacc tccgtgcaca aagtgctctc ctgcccccaa actgaggggt ccttggtggg
     3601 gactgaccta aaatagtaac ctggattctt gttgcacacc tgccacatcc agggctgcgt
     3661 gaccatggct gagtgcactg cttctctgtg tgtccaatga ttcctttata gattgatgca
     3721 gtgaaccaca gtggcacagc tcaggagatt ttctgggtga gacatgccct acttccttgc
     3781 attctttgtg tccaagatgg aggagtcccc cagccatgtg tcatggcagc tttgctcagt
     3841 gcagttattc actgtctttt gagccacaga aaatgtcact gtgaagttga tcaagggaag
     3901 cctgtgcttg tcctctgttc acagactctt gagcatgatg gtggaaacta aaactgtttg
     3961 gtgagtgaga gagttgctca tggaggcttg gtatggtcct tccacagttt tcctgcctgc
     4021 cggatgggac ttatggggtg agcccacagt agaccttctt tgtgtgtgcc tcggtttcct
     4081 catttgtaaa atccacgtgt ctcacctgct tcacaaagtc gtcatgagga tgagccatcc
     4141 agcctttttt tttttttttt ttttgaaaaa atatctttaa tcctatccct gtgcaggtga
     4201 ggtctgggag ttaaactgag gtcctcagta agagtggttt atgcccttac ttcagcacca
     4261 tctctacagc cgagtgctcc taagtcttaa ggctcaatac ccataagagg caggaaccat
     4321 ggacaaaccg ccatgcaggt aggaacagtc aaagccaagt cctgcctgcc atcttgtctc
     4381 tgtcccttca gacaccgggg aggaaagcac atcctccaga tgtttcaacc tgaatagcaa
     4441 caaccttcag tgcttgcaac accaaagctg tcacaaagcc ggagcaggaa ctccataacc
     4501 tgtcgccatt tctcatttat tcttgttgtc tggtatacag taggtgctca tatgtgtttg
     4561 actcttgcct catgctcaat tattccagta cctcagggtt atgtatgcaa ataaagattt
     4621 atcaaatctc aa
//
LOCUS       NM_001436673            3528 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 3, mRNA.
ACCESSION   NM_001436673
VERSION     NM_001436673.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3528)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3528)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3528)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3528)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.53183.1,
                                           SRR26643287.32186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               JAXUCZ010000016.1  6453402-6453691
            291-345             JAXUCZ010000016.1  6453812-6453866
            346-478             JAXUCZ010000016.1  6454871-6455003
            479-598             JAXUCZ010000016.1  6455366-6455485
            599-660             JAXUCZ010000016.1  6455976-6456037
            661-803             JAXUCZ010000016.1  6456213-6456355
            804-882             JAXUCZ010000016.1  6456604-6456682
            883-1006            JAXUCZ010000016.1  6457065-6457188
            1007-1154           JAXUCZ010000016.1  6457443-6457590
            1155-1339           JAXUCZ010000016.1  6458022-6458206
            1340-1467           JAXUCZ010000016.1  6458575-6458702
            1468-1946           JAXUCZ010000016.1  6459242-6459720
            1947-2107           JAXUCZ010000016.1  6459835-6459995
            2108-2200           JAXUCZ010000016.1  6460240-6460332
            2201-2273           JAXUCZ010000016.1  6460433-6460505
            2274-3528           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3528
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..290
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    158..160
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     exon            291..345
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..478
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..2407
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 3"
                     /protein_id="NP_001423602.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFS
                     PESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF
                     ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRV
                     KYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLE
                     AGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQ
                     RLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSA
                     IRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGS
                     PAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVL
                     FGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSS
                     QGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYE
                     ACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS
                     IGRLHKQRKPDRRKRSRPYKAKRQ"
     misc_feature    <461..922
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    <461..922
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    order(476..478,494..496,728..730,773..775)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(476..478,494..496,728..730,773..775)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(476..478,494..496,728..730,773..775)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(476..478,494..496,728..730,773..775)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    2144..2281
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2144..2281
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     exon            479..598
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..660
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..803
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..882
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1006
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1154
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1339
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1467
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1946
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2107
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2200
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2273
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..3528
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgt ggggctgaga agccccgagg gcggtgggcg
       61 ctcccggtgg gggcggcgcg gggttagcag ggcctggaca tggcgctgag agaccgctcc
      121 gcgggaagat gaataagggc tggctggagc tggagagtga cccgggtacg gaggggcctc
      181 ggcgggccgg gggctgggga ggccggatgg gccccggact cacctgcctg acaaatccct
      241 cttcttgtcc tcccacccag gcctcttcac cctcctggtg gaagatttcg gtgtcaaagg
      301 ggtgcaagtg gaggagatct atgaccttca gagtaaatgc caggggcctg tatatggatt
      361 tatcttcctg ttcaaatgga tcgaagagcg caggtcccgc cgcaaggttt ctacgttggt
      421 ggatgataca tctgtgattg atgatgacat cgtgaatagc atgttctttg ctcaccagct
      481 gattcccaac tcttgtgcca ctcacgcctt gctgagcgtg cttctgaact gcagcaatgt
      541 ggatttgggg cccacgctga gtcgaatgaa ggatttcacc aaaggcttca gccctgagag
      601 caaaggatat gcgattggca atgcccctga actggccaag gcacataata gccatgccag
      661 gccagaacca cgtcaccttc ctgagaaaca gaatggcctc agtgcagtgc ggaccatgga
      721 ggcgtttcac tttgtcagct atgtgcctat cacaggacgg ctctttgaat tggatgggtt
      781 gaaagtctac cctattgatc atgggccctg gggagaggat gaggagtgga cagataaagc
      841 ccgaagggtc atcatggagc gaatcggcct tgctactgca ggggagccct accatgacat
      901 tcgcttcaac ctgatggcag tggtgcctga ccgcagggtt aagtatgagg ccaggctgca
      961 tgtgctgaag gggaaccgac aaacagtcct ggaggccctg cagcagctga ttagagtaac
     1021 acagccagag ctgattcaga cccacaaatc tcaagagtca caactgcctg aggagagcaa
     1081 gccagccagc agcaagtctc cctttgggct agaggcgggc agaaccccgg cggcctctga
     1141 gtgcactcac acagatggtg cagaggaggt ggctggttcg tgcccacaaa ctacaaccca
     1201 tagtcctccc agcaaatcta agctggtggt gaagccttca gggagcagcc tcaatggggt
     1261 tcccccaacc cctaccccta ttgtccagcg gctgccagcc tttctagata atcacaatta
     1321 tgccaaatcc cctatgcagg aggaggaaga cctggcggca ggtgtgggcc gcagccgagt
     1381 tccagtccga ccccagcagt actctgatga tgaggaggac tatgaggatg aggaggagga
     1441 tgtgcagaat accagttctg ccatcagata caagcggaag gggacaggga agccaggatc
     1501 gttgagcaat tcttcagatg ggcagctgtc agtgctgcag cccaacacca tcaatgtctt
     1561 aactgagaag cttcaagagt ctcagaaaga cctttcaatt cctctgtcca tcaagactag
     1621 cagtggggct gggagtccag ccgtggctgt gcccacacac tcgcagcctt cacccacccc
     1681 tagcaatgag agcacggaca cagcctctga gattggcagt gctttcaact cacccttgcg
     1741 ctcacccatc cgctcagcca acccaacacg gccctctagc cctgtcacct ctcacatctc
     1801 caaggtgctc tttggagaag atgacagcct acttcgtgtt gactgcatac gctacaaccg
     1861 tgctgtccgt gacctgggtc ctgtcattag cacgggcctg ctgcaccttg ctgaggatgg
     1921 tgtactgagt cccctggcac tcacagaggg tgggaagggt tcctcacctt ctaccagatc
     1981 aagccaaggc agccaggggt ccagcagcct agaggagaag gaggtggtgg aagtcacaga
     2041 tagcagagac aagtctgggc tgaacaggtc cagtgagccc ttgagtggag agaagtactc
     2101 gcccaaggag ctgttagcac tgttaaagtg tgtagaggcc gagattgcaa actatgaggc
     2161 ctgtctcaag gaggaggtgg agaaaaggaa gaagttcaag attgatgacc agcgaaggac
     2221 ccacaactat gatgagttca tctgcacctt catatccatg ctggctcagg aaggaatgct
     2281 ggccaacctg gtggagcaga acatctcagt gcggcgccgc caaggggtca gcattggtcg
     2341 gcttcacaag cagcggaagc ctgataggcg gaaacgctct cgcccctaca aggccaaacg
     2401 ccagtgagga cctctagccc tgactctgca gcctctcttg ccgcaaggcc ctcaccaggg
     2461 cccttcactg ttcgactttt ccaagtatta ctgaatagtt cagctagagc tcaggccctg
     2521 ggagtaggaa tgggatgtgt attctgcatt atgctctggg gtctggcagg gacaaggcag
     2581 ctccataatg ctcaggaagc agcagctgga attggagggt gctgtggcct ccacggccat
     2641 ctgaggagca gcaggatata tattctacct gttggagatg tctatttttt tgacttttgg
     2701 ccatcttgcc actgtattaa catggccagc ttcctgactc tgctttctct cccagcagct
     2761 gtcattctgc tgggcccagg tctcttataa ccacagtacc agctgggaaa cccagaaggc
     2821 attggtcctg gtgctctagc accagccacc agcctgtcct tgttgtgaag aagcttggcc
     2881 tactactctt gattccttct gggagagcgc caaactcagg gacctggctg ctgagctgga
     2941 atgggcatgg ggtatcctag taggatgtac agcctatcag ggtcccacag ctatcgtgga
     3001 gacaagtgtt tgaactgtcc tcgtaccacc cagacttgtt agtgagtcag agcagggctc
     3061 tggggctctt tgccttcagt gttgtggccc tggccgtggg cctaccttag gctcctaatc
     3121 tccgtctctg gggtccagag gagccactac ttagcccctc agtattacca tgtctcctct
     3181 taggaatgtc agaggcaggg ctgctcgaat gaggctggca ctattcaatt ctcccgaccg
     3241 tgccagcttc cttggcctca tgcaggtact cagggtaggg gacagggtca agaggagtta
     3301 gaacttctgt gttcccatag ggcttgatgc cagtggggta gtaagcacag cactgcttca
     3361 agctccaggc ccagatagcc ctgtgccctc tgctagatac aggtgatcca agcaggcccc
     3421 ttacctgtac atagcaactg tcggggggat ggtacagcag tccgacccgc tatagtgtct
     3481 gtaaatactg aatcagtgag tgaagaataa aagtgtgcta ataagtga
//
LOCUS       NM_001106661            3793 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 268 (Tmem268), transcript
            variant 2, mRNA.
ACCESSION   NM_001106661 XM_001064554 XM_233020
VERSION     NM_001106661.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001106661.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360176.2258420.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000005.1  81992811-81992992
            183-291             JAXUCZ010000005.1  81993536-81993644
            292-481             JAXUCZ010000005.1  81995120-81995309
            482-591             JAXUCZ010000005.1  81998175-81998284
            592-699             JAXUCZ010000005.1  82002470-82002577
            700-849             JAXUCZ010000005.1  82003984-82004133
            850-960             JAXUCZ010000005.1  82008206-82008316
            961-1041            JAXUCZ010000005.1  82010409-82010489
            1042-1221           JAXUCZ010000005.1  82010883-82011062
            1222-3793           JAXUCZ010000005.1  82014399-82016970
FEATURES             Location/Qualifiers
     source          1..3793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3793
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
     exon            1..182
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            183..291
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            292..481
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    346..348
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="upstream in-frame stop codon"
     CDS             373..1401
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001100131.1"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
                     /translation="MACEPPSDPGGAAGPLPTSTLGCSTLPQGNPPGWGEELHNGQVL
                     SVLRIDNTCAPISFDLRVAEEQLQAWGIQVPAEQYRSLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAVSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVERPEDLEDSPLLPRTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSQLPQPMGTRHMDSARIPCPCQLIEVHILGT
                     GCCPFLAR"
     misc_feature    487..1356
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     misc_feature    487..1356
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     exon            482..591
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            592..699
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            700..849
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            850..960
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1041
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1221
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..3793
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtactgtga ggcttcactg agagggcctg agtcctccgc caggagtaca gatgtcaagg
       61 ttgtatctgc ctggtggcct agaagttgat cagaggcagc aggggagcac aaccttgcat
      121 ctgtttcacg gtttttgtgc ctgttgggtg tatagaagga ggaggtacga taaagtaggc
      181 tggaatcccc acactcccac tttgcaggtc atcccagcct cgtgtaactg ctcctgttga
      241 agccttgagc tacacagcga agaggccaga aggctcagtg cctccctgaa ggcaagtgga
      301 ggtgagacgc tgcccggtgt gaactgcacc cctagaaaca ggaagtagaa gctagaccgc
      361 tgtctgtctg ccatggcttg tgaacctccc tcagatcctg gtggggcagc tggtcctctg
      421 cccacctcca ccctgggctg cagcaccctg cctcagggga accctcctgg ctggggggaa
      481 gagctacaca atggccaggt cctctcagtc ctccggatcg acaacacctg tgcacccatc
      541 tcctttgacc tgagagttgc agaagaacag ctgcaggcct ggggcattca ggtccctgct
      601 gagcagtata ggagcttggc tgagagtgcg cttttggagc ctcaagtgag gaggtacatc
      661 atctacaact ccaggcccat gaggctggcc tttgctgtgg tgttctatgt gttggtgtgg
      721 gccaacatct actccaccag ccaaatgttt gccctaggca accagtgggc aggtgtgctg
      781 cttgcgaccc tggccgctgt cagcctgacc ctgactcttg tgctggtctt tgagaggcag
      841 cagaggaagg ctaacactaa cacagacctg aggctggtgg ctgccaatgg agcccttctg
      901 agacaccgag tgctgctggg ggtgacagat accgtggagg gatgccagag tgtgatacag
      961 ctctggtttg tctactttga cctggagaac tgtgtgcagt tcttgtccga tcatgtccaa
     1021 gaaatgaaga ggagtcagga gtccttgctg agaagcagat taagccagct atgtgttgtc
     1081 atggagactg gagtgagccc cgtggtggaa aggcctgagg acttggaaga ttctcccctc
     1141 ctgcccagaa ctcctggtcc tcaggagaga ccactcacac agactgaact ctatcagctt
     1201 gttccagagg ctgagccaga ggagatggcc cggcaactgc tggcagtgtt tggtggctac
     1261 tacacccggc tcctggtgac ctctcagctc cctcagccaa tgggaacacg acacatggac
     1321 tctgcaagga tcccatgccc ctgccagctc atagaagtac acattttggg cacaggatgt
     1381 tgcccattcc tggccaggtg acctagggat gaaggtgttc atcttcctcc aagactaaga
     1441 agtaggggag gagtcaggag cccagcatgg ccaccagtga gctcagatga ggtcagcgtt
     1501 tggagacact ttctcaagtg tcagtcatgt aggcctttgg gtcatcaagt gcacaccaga
     1561 tgtcttcttg gcatcatact ctgtcctggc cttgctgaat ctggtggctg agctggtggc
     1621 tggccttgca gcctggatgg aggatactgt ctgttgcctg tcaaggccta gggacctgca
     1681 gctgactcca cagggcaagt gcctgaccct ggggtcagaa agtgagacca aggctccaag
     1741 gagacgccca tctttcagcg gtgcctcagt ctgccggtca caacctacct gccctcaatg
     1801 tgagggaaga ttcttggaag ggtgagctag cttgtgagtg acagtaccgt ctgggattgt
     1861 tgtctgttag caccaaggtt agagagggct agggttggag gatgggtgag gagacaaaag
     1921 cctggcagat gaccatcaac aaggggcact ggaaaagaag ctcctgttat actcagtgac
     1981 tttgcactgg cttgctgctt gtgaatgtgt ttctcttctg ccaagcagca gtggtgtttt
     2041 ctgacactaa cattgttctg gaatgaggta tgattagaca ctctgggttt atgtgaagaa
     2101 ctcagcgact ttcccaaagt tggaagactg tctacagccc tatgcccaga gccctggact
     2161 cgtgtaaagg tcctgctcca tgaaccagcc tttgtggttt ttgtcctcca caaatcatca
     2221 ttataagttg gaactcttcc tggaactggc tggcatatgc attcattcct gttggactct
     2281 tattcatcct tcaaaaccct acttttcata tccttcctgc tgctttctgt ctcactgaaa
     2341 ttctgatgga actgcccccc ttatggatgt tttatgttat tcagtgtttc tcctgtacat
     2401 acctcttttt ctatcaagac tgtaaactcc tcaaggtcca acactgcacc caccttcctt
     2461 ttgggaatga cttggacttg tttagaaaaa aaaaacaatt ttgaaaagtc ccatggattg
     2521 gtcgccttgc cctctccacc cattgtggca aatgcttctg gaagacatgg ttgaatggta
     2581 aggcccaggt cgtgatggac cagaggtctg gtctgcagct gtgtcactct atttgtgcac
     2641 cctctgtttg cccatctcta cagctggatg attttggtga tttccagctt gtgctgtttg
     2701 ttattcttac ctccgtgcac aaagtgctct cctgccccca aactgagggg tccttggtgg
     2761 ggactgacct aaaatagtaa cctggattct tgttgcacac ctgccacatc cagggctgcg
     2821 tgaccatggc tgagtgcact gcttctctgt gtgtccaatg attcctttat agattgatgc
     2881 agtgaaccac agtggcacag ctcaggagat tttctgggtg agacatgccc tacttccttg
     2941 cattctttgt gtccaagatg gaggagtccc ccagccatgt gtcatggcag ctttgctcag
     3001 tgcagttatt cactgtcttt tgagccacag aaaatgtcac tgtgaagttg atcaagggaa
     3061 gcctgtgctt gtcctctgtt cacagactct tgagcatgat ggtggaaact aaaactgttt
     3121 ggtgagtgag agagttgctc atggaggctt ggtatggtcc ttccacagtt ttcctgcctg
     3181 ccggatggga cttatggggt gagcccacag tagaccttct ttgtgtgtgc ctcggtttcc
     3241 tcatttgtaa aatccacgtg tctcacctgc ttcacaaagt cgtcatgagg atgagccatc
     3301 cagccttttt tttttttttt tttttgaaaa aatatcttta atcctatccc tgtgcaggtg
     3361 aggtctggga gttaaactga ggtcctcagt aagagtggtt tatgccctta cttcagcacc
     3421 atctctacag ccgagtgctc ctaagtctta aggctcaata cccataagag gcaggaacca
     3481 tggacaaacc gccatgcagg taggaacagt caaagccaag tcctgcctgc catcttgtct
     3541 ctgtcccttc agacaccggg gaggaaagca catcctccag atgtttcaac ctgaatagca
     3601 acaaccttca gtgcttgcaa caccaaagct gtcacaaagc cggagcagga actccataac
     3661 ctgtcgccat ttctcattta ttcttgttgt ctggtataca gtaggtgctc atatgtgttt
     3721 gactcttgcc tcatgctcaa ttattccagt acctcagggt tatgtatgca aataaagatt
     3781 tatcaaatct caa
//
LOCUS       NM_001436698            3172 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 5, mRNA.
ACCESSION   NM_001436698
VERSION     NM_001436698.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3172)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 3172)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 3172)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 3172)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 3172)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 3172)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 3172)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 3172)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3172)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 3172)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29401.1,
                                           SRR26360181.1055426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000005.1  135319570-135319609 c
            41-138              JAXUCZ010000005.1  135319012-135319109 c
            139-220             JAXUCZ010000005.1  135318229-135318310 c
            221-268             JAXUCZ010000005.1  135314949-135314996 c
            269-379             JAXUCZ010000005.1  135311284-135311394 c
            380-460             JAXUCZ010000005.1  135306753-135306833 c
            461-570             JAXUCZ010000005.1  135304577-135304686 c
            571-1551            JAXUCZ010000005.1  135302980-135303960 c
            1552-1631           JAXUCZ010000005.1  135298279-135298358 c
            1632-1717           JAXUCZ010000005.1  135297655-135297740 c
            1718-1791           JAXUCZ010000005.1  135297473-135297546 c
            1792-1980           JAXUCZ010000005.1  135296880-135297068 c
            1981-2147           JAXUCZ010000005.1  135296609-135296775 c
            2148-2204           JAXUCZ010000005.1  135296062-135296118 c
            2205-2282           JAXUCZ010000005.1  135295896-135295973 c
            2283-2411           JAXUCZ010000005.1  135295084-135295212 c
            2412-3172           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..3172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3172
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..40
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            41..138
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            139..220
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    210..212
                     /gene="Nasp"
                     /note="upstream in-frame stop codon"
     exon            221..268
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2492
                     /gene="Nasp"
                     /note="isoform b is encoded by transcript variant 5;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform b"
                     /protein_id="NP_001423627.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKY
                     GETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNV
                     DEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDMDISEPAEK
                     LQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQNK
                     EFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDV
                     GGEEPKDQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNG
                     PVVGQSSAGDQTPSEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGD
                     GVETKVAQRATEKAPEDKFKIAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTN
                     ESVLEKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSV
                     ESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSI
                     DVIEKRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELA
                     LKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESP
                     RKDDAKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKS
                     TAC"
     misc_feature    <549..1679
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <549..1679
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    1656..1727
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1656..1727
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1743..1973
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1743..1973
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1749..1862
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1749..1862
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1749..1835
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1749..1835
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1752..1754,1761..1766,1773..1778,1782..1784,
                     1878..1880,1887..1892,1899..1904,1908..1913,1974..1976,
                     1983..1988,1995..1997)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1752..1754,1761..1766,1773..1778,1782..1784,
                     1878..1880,1887..1892,1899..1904,1908..1913,1974..1976,
                     1983..1988,1995..1997)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1848..1964
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1848..1964
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            269..379
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            380..460
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            461..570
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1551
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1631
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1717
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1791
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1980
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2147
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2204
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2282
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2411
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..3172
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagactgaga gggcataggg aagacctgtc accttctcgg gcagtatact gcccactggc
       61 ccaccacctc aggggaacga tggccacaga gtctacagcc actgctgcca tcgccgcgga
      121 actggtttcc gctgacaaag aagtgtcgtg gttctttagg ttttcactga gtcggagatt
      181 ttgtagcttc aagagacatt tcacttgtgt agcgtctaag agttgaagat gctcctgctc
      241 cttctacctc tgcagataaa atggagagtc tggatgtgga tagtgaagct aagaaactac
      301 tgggattagg acagaaacat ctggtgatgg gtgacattcc agcagctgtt aatgcattcc
      361 aagaagcagc tagtctttta ggtaagaagt atggagaaac ggctaatgag tgtggagaag
      421 ccttcttttt ttatgggaag tcacttctgg agttggccag aatggagaat ggagtgttgg
      481 gaaatgcctt agaaggagtg catgtagaag aggaagaagg agaaaaaaca gaagatgaat
      541 ctttggtaga aaataatgat aatgtagatg aggaagcaag ggaagagttg agagaacagg
      601 tttatgacgc catgggagaa aaagaagcca aaaaagcaga aggccagtct ctgacaaagc
      661 ctgaaactga taaagaacag gaaagtgaag tggagaaggg tggaagagaa gatatggata
      721 taagtgagcc tgcagagaag ctccaggaaa aagttgaatc gacttcaaag cagttaactg
      781 aatcctctga agaggcaaaa gaagcagcaa taccaggact gaatgaagat gaggtcactt
      841 ctgggaagac agaacaggaa tcattgtgta ctgaggaagg aaaatccatt tctggagttt
      901 atgttcaaaa taaagaattc agagaagcag tgcctcagga ggagggagag gaaatgataa
      961 gcttagaaaa aaagccaaaa gaaacttcag aagatcagac tattggggct ccagaaaagc
     1021 aggacacttt aatgaaggtg gtagaaatag aagctgaaat agactctgaa gtcaagtcag
     1081 tggatgtggg tggggaggag ccgaaggatc agggagctat ctctgagagt gaactaggaa
     1141 aggctgttct tatgcaactc tcagggcaag atgttgaagt atcaccagta gtggctgcag
     1201 aggctggatc agaagtctct gagaagccag ggcaggagat tacagttctt cccaacaatg
     1261 gtccagttgt tggacaatca tctgcaggag atcaaactcc tagtgaacca cagaattctg
     1321 cagaaagact gtcagaaact aaagatggcg caagtgtaga ggaggtcaag gcagagctgg
     1381 ttcctgaaca ggaggaagct atgcctcctg tagaagagtc tgaggcagct ggagatgggg
     1441 ttgagaccaa ggtagcccag agggccacgg agaaagcacc tgaagacaaa tttaagatag
     1501 ctgctaatga agagacacaa gagagagacg aacagatgaa agagggtgaa gaaactgaag
     1561 gctcagagga agaagacaaa gaaaatgaca aggctgaaga aacaacaaat gaatcagttc
     1621 ttgaaaaaaa gactcttcaa gaaaatgaag aagaggagat tgggaattta gaacttgcct
     1681 gggatatgct agatttagcc aagattattt ttaagaggca agaaacaaaa gaagcccagc
     1741 tttatgctgc acaagcccat cttaaacttg gagaagttag tgttgaatct gagaattata
     1801 tccaagctgt ggaggagttt caggcttgcc taagcctgca agagcagtat ttggaagctc
     1861 acgatcgtct ccttgcggag actcactacc agttgggttt ggcctatggt tacaactctc
     1921 agtatgatga ggctgtagca cagtttggca aatctattga cgtcattgag aagagaatgg
     1981 ctgtactact tgagcagatg aaggaggctg aaggatcatt tactgaatac gagaaagaaa
     2041 tcgaggagct gaaagaactg ctccccgaga ttcgggagaa gatagaggat gcaaaggagt
     2101 ctcagcggag tgggaatgta gctgagctgg ctctgaaggc cactctggtc gagagctcta
     2161 cttcaggttt cactcctagt ggagctggtg cctcggtatc catgattgcc agtagaaaac
     2221 caacagatgg cgcttcctca tcaaactgtg tcactgatat ttctcatctt gtcagaaaga
     2281 agaggaaacc agaggaagag agtccccgga aagatgatgc aaagaaagct aaaccagaac
     2341 cagaggtgaa tggaggcagt ggagatgctg tctccagtgg aaatgaagtt tcagaaaaca
     2401 tggaggcaga ggctgagaat caggctgaga gccagacaac agcagaaggg acagtggact
     2461 ctgcagctac agttaaaagc actgcatgtt aagaggcgag cagaaccttc ctcctgaggg
     2521 aaagtggttt tgtacataat gtattttttc acttttgggg attctttttg tataactcca
     2581 ataaagattg taggcaacag ctgagacttt gatggctttt ttcttaaaaa tattggtgga
     2641 ttgttttggg gcactctata ttgtgtatac atgccttgtg ttttgctact gcacaaccca
     2701 cttcctgtct aatgtggagg tgatcaagtt gatcaaggcc cttcatctac tggtgctatg
     2761 tttctatttc caaatatttg gctgaattca aataccttgt aagctttcca tggtgctgtc
     2821 cctggatggg gtctgctaaa caagaactgg tagaaatcag tttggtgctg aaaatggagc
     2881 atggaatatg acccaggtct tggtttgtgc ctaccttctg ttcacctggt ttccatttaa
     2941 ggccataata tcctgccctg gcaaaactgg cagaaacatg ggaaatgatt cctgaggaaa
     3001 actgttgtta gatactccgt aggatcacac tgtagtggga gacaagtaga agactatgat
     3061 tgagaagtct gttacgttat tttctgtata gaaagattac aatatgtcaa taagtggaat
     3121 tgttatattg tgcagttttg tctataaaaa taaatatgct aattttaaca aa
//
LOCUS       NM_001013935            2298 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1-like (Mtfr1l),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001013935 XM_216546
VERSION     NM_001013935.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001013935.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083692.1, SRR26643299.24796.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000005.1  152030400-152030426 c
            28-153              JAXUCZ010000005.1  152027744-152027869 c
            154-258             JAXUCZ010000005.1  152027268-152027372 c
            259-368             JAXUCZ010000005.1  152025746-152025855 c
            369-580             JAXUCZ010000005.1  152025303-152025514 c
            581-902             JAXUCZ010000005.1  152024076-152024397 c
            903-2298            JAXUCZ010000005.1  152020175-152021570 c
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2298
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="mitochondrial fission regulator 1-like"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
     exon            1..27
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            28..153
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="upstream in-frame stop codon"
     CDS             139..1008
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="isoform a is encoded by transcript variant 2;
                     protein FAM54B; family with sequence similarity 54, member
                     B"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1-like isoform
                     a"
                     /protein_id="NP_001013957.1"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
                     /translation="MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPN
                     ISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVP
                     NLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSSG
                     SSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTT
                     CSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRK
                     FALKEEDISRKGN"
     misc_feature    157..888
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    157..888
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    217..219
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    250..252
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    436..438
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    457..459
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    799..801
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    802..804
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    841..843
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    910..912
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    946..948
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     exon            154..258
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            259..368
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            369..580
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            581..902
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2298
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtgagtc tggagctcga atctgaggaa aggaagtctc atgctccggg aaatggcctg
       61 atatgaagga gtcacacctc cagccttccc tgtgggtgcc ttgtcctttg ggtgcaggag
      121 ctggctgaaa catcaggaat ggaagccaat gtgactatcc caatctggca gaacaagcca
      181 catggggctg ctcgcagtgt ggtaagaaga attgggacca atctgcccct gaaaccttgt
      241 ccacgggcat cctttgagac cctgcccaac atctctgacc tgtgtttgaa agatgtgcct
      301 ccagtcccga ctctggctga catcgcctgg attgccgcag atgaagagga gacatatgct
      361 cgggtcagga gcgatacacg ccctctgaga catacctgga agcccagccc tctgattgtc
      421 atgcaacgga atgcctcagt gcccaatctg cgtgggtctg aggagaggct cctggccctg
      481 aagaagccag ccctgcctgc cctaagccgc accactgagc tgcaggatga actaagccac
      541 ctgcgcagcc agattgctaa aatagtggca gcagatgcag cttcggcctc attaacgcca
      601 gatttcttat cttcaggaag ttcaaatgtc tcctctcctt tgccttgctt tggatcctca
      661 ttccactcta caacttcctt tgtcattagt gacatcactg aggagactga ggttgaggtc
      721 cccgagcttc caacaatccc cctgctttgt tctgccagcc ctgaatgttg caaatcagaa
      781 cacaaaacta cctgcagctc gtctgaagag gatgactgca tctctctgtc caaggccagc
      841 agctttgcag acatgatggg catcctgaag gattttcatc ggataaaaca gagccaagac
      901 ctgagccgga gtttactgaa ggaagaagac cctgctgtcc ttatctctga ggtccttagg
      961 aggaagtttg ccctgaagga agaagacatc agtagaaaag gaaactgaca gcactgactg
     1021 caaactcttc tcttgctcct gaactccttc aatagctgcc ttcctcactg cagatgtctg
     1081 tctcagttga gatctgaaca gtcttgctga ctagggcttg ggctggaaga gaagagctgg
     1141 attatttgtt acctgcactt aaaccctggc agagtctaag gtctatggtt tttggagatg
     1201 tgacatttgt tacaggtaat tgggtagagt ggagtatctc tgcttaaggc gtgaagtttg
     1261 ttttttcttg tctctgaaaa ataagccctc tatgaatgac ttaattaact cactgcatta
     1321 gactccataa ttggtctcac tggacatgtt gtgcacagca gtcactctcg gcagcttccc
     1381 tgcagcacca cagggctgag ggggagcggc tgttagttca tgctcacagg aaggtcttct
     1441 gctgcttcat cacagacata caccagtgcc cacagtcacc ctttccctct agctgcagag
     1501 ggcaggccac tgggccagcc aatatctggg ctgctgcagg gaggcctggc ctgttttttc
     1561 ttaaacattt tataaaacta caacctgatc taccctccag ggcctcatta gttccactga
     1621 ttgaattttt ttttcttcca tggacttact aagtccatct tggaaggaga aatgtggaga
     1681 caaaaagagc ataccatcct tctaggacag tgactgatct ctctaggttg ggtcaagatt
     1741 ttatttactg catcatgcat gactcaggtg ccctcagggc ccttttctct atggtatgaa
     1801 tactgtgtgt tttgagttga agcattacct gatattaaat gaaggatttg gagaaatggt
     1861 gtagtttttc tttattctgt ctctgaattt tgaccacagt ggcctctggt gaagagaggg
     1921 ctcctgttga ttctaaggta tgtgaacttt taaaaaacag gctcctgact tcctttcttg
     1981 ccctcaggac agtggtgctc actgtgaccc tttaatacaa gtccttatgc tatggtgacc
     2041 ccctctcccc acatccataa aattttgttg ctacttcata actaaatttg ctaccattaa
     2101 gagttgtaat atgggctgta tagacggctc agtggttggg agcactgact gttctttccg
     2161 gaggttctga gttcaaatcc cagcaatgac atcgtggctc aaaaccatct gtaatgagat
     2221 ccgatgccct cttctggtgt gtctgaagac agctacagtg tacttacata taataaataa
     2281 ataaatctta aaaaaaaa
//
LOCUS       NM_001436709            3051 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 6, mRNA.
ACCESSION   NM_001436709 XM_039109613
VERSION     NM_001436709.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3051)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_039109613.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.22368.1,
                                           SRR26643295.22559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2337           JAXUCZ010000005.1  140860181-140860300
            2338-2465           JAXUCZ010000005.1  140860911-140861038
            2466-2559           JAXUCZ010000005.1  140862618-140862711
            2560-2690           JAXUCZ010000005.1  140862797-140862927
            2691-2750           JAXUCZ010000005.1  140863198-140863257
            2751-3051           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3051
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2768
                     /gene="Pabpc4"
                     /note="isoform 6 is encoded by transcript variant 6;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 6"
                     /protein_id="NP_001423638.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGNAPASRGLPTTAQRVGVPTAVPNLAPRATVAAAAPRAVA
                     PYKYASNVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLI
                     QTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKES
                     KAK"
     misc_feature    915..2717
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2717
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2337
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2465
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2559
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2690
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2750
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..3051
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg taatgctccg gcctctcgtg gccttcctac taccgctcag agagtcggcg
     2341 tccctacggc tgtgccaaac cttgcacctc gtgctacagt cgctgctgct gctcccaggg
     2401 ctgtggctcc atacaagtat gcctccaatg tccgcagccc tcaccctgcc attcagccgc
     2461 tgcaggcccc ccagcctgca gtccatgtcc agggtcaaga acccctgact gcctccatgc
     2521 tggctgcagc tcctccccag gagcagaagc agatgctggg ggagcgtttg ttcccactta
     2581 tccaaacaat gcattcaaac ctggctggaa aaattacagg gatgctgcta gaaatcgaca
     2641 actctgagct gctccacatg ctggagtccc ccgagtccct ccgttccaag gtggatgaag
     2701 ctgtggcagt cctgcaggct catcatgcca agaaagaagc tgcccagaag gagtcaaaag
     2761 ccaaataacc cctcacggca ttcagctgag gtctgaagac ttcctagttt gtctgtggac
     2821 ctctttcaag aaccaagtta caaattcaac aggtcatttt gtatcaaaag gtcaattatg
     2881 aagcacctag aatttttcaa ttataagaat atattctctg ggttctgttg tggcccagat
     2941 gatggtaact tttttttcta ttatgagttc tgtttttttt cccctctccc agaaattggt
     3001 tttgatgtac ccaagactta agtttctcaa taaaggaaat aaaatctcca a
//
LOCUS       NM_001436690            1726 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 6, mRNA.
ACCESSION   NM_001436690 XM_063275356
VERSION     NM_001436690.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063275356.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32233.1,
                                           SRR26360186.2361760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-365             JAXUCZ010000016.1  7305064-7305184
            366-429             JAXUCZ010000016.1  7305489-7305552
            430-536             JAXUCZ010000016.1  7308347-7308453
            537-678             JAXUCZ010000016.1  7309595-7309736
            679-787             JAXUCZ010000016.1  7326003-7326111
            788-1726            JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1726
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    211..213
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..365
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..942
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 3 is encoded by transcript variant 6;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 3"
                     /protein_id="NP_001423619.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKKNILDLVHEFPEKIACSF
                     HVTKQTTQISSELKPYVTDGRITEKEIREHISAETLFYVCGPPPMTDFFSKHLESSHV
                     PKEHICFEKWW"
     misc_feature    454..930
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    454..930
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(535..537,571..582,631..639,649..660)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(535..537,571..582,631..639,649..660)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(571..573,577..582)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(571..573,577..582)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     exon            366..429
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            430..536
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            537..678
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            679..787
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1726
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcaggcagca ccatggccca tgtcttgatt cctgggttgt ctcgaggctc tgtgggagcc
      301 atctgcactc aggctgcttc gtgggcactg cctaccagca ctctgcgttc ccttacctta
      361 gccagcgtaa tgagatccag aaggaaaact gaccacctag agagaaccgc cactgtcctc
      421 cgccgggagg tcatggctgc agctaaggtg tgtgagatca ctcacgagtc tccatcagtg
      481 aagagcctcc gtttgcttgt tgctgataaa gacttttcct tcaaggctgg ccagtgggtt
      541 gatttcttca tcccaggagt ttcagtggtt ggtgggtttt caatttgctc cagtccccaa
      601 cagctagaac gagagagaat aatagaattg gcagtgaaat acacgaacca tcctcctgct
      661 gtctgggttc acaataagaa aaatatcctc gacttagtac atgagtttcc tgagaagatt
      721 gcctgcagtt ttcacgttac aaaacagacg acccaaatca gttctgaact taagccttat
      781 gtcacagatg gaagaataac agagaaggag ataagagagc acatttcggc agagactctg
      841 ttctatgtct gcggcccacc tccaatgaca gactttttct ctaagcatct ggaaagcagc
      901 cacgttccca aggaacacat ctgctttgag aagtggtggt aggagcaggc acagaagacc
      961 tgagagccgc tcaggacagt gagaaccagc aacagagtca cacgagaaac ttcccgcaga
     1021 cttcattggt ggcactattt ttcactatat tgatttttct ttcattaatt atcctatgat
     1081 agttcattat tacagaattt ctgacctttg gggaaaagac catgctcaac ccaattgtaa
     1141 ttaaaagatt tactgatgag ctgctggcag gaagacaggc tgagagccag atttgagatg
     1201 gccataaata aaagagggtg gggggaaagg tttcccaaag ggaaaaccat ggggaggctc
     1261 acggtatcta tgcaagcagg cagactctgg cctgttctgc caagattaag tgggtaaagc
     1321 aactggaaac aatctgggtg tctgcacacg caagttacag aagctgaaaa cggcctccat
     1381 agccaggaga agctcacagc tgtgcgtttc tggggacccc tgagccaggg ctgttttctg
     1441 ggaccccgtc tttctggaat tttgagtcta tggcgagcag tcatcagtac taagatggag
     1501 ggaggcctag aaaaaaatag tttctcgagt tggcctttac accacgaact gattaataca
     1561 ggtttttctt ttgccctttg ggggcaaatt agtctaatta tgttaattaa aggaaagtgt
     1621 gggttttgtg tgaactgtat acttctctaa ataattggac agaaattcat aaaatttatg
     1681 tttactgaat ttataatttt aaatacattc tttattttga aatgtc
//
LOCUS       NM_001436689            2171 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 5, mRNA.
ACCESSION   NM_001436689 XM_063275355
VERSION     NM_001436689.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063275355.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2476715.1,
                                           SRR26643290.47348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-631             JAXUCZ010000016.1  7305896-7306083
            632-738             JAXUCZ010000016.1  7308347-7308453
            739-880             JAXUCZ010000016.1  7309595-7309736
            881-1123            JAXUCZ010000016.1  7324014-7324256
            1124-1232           JAXUCZ010000016.1  7326003-7326111
            1233-2171           JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2171
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..631
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    608..610
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            632..738
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             635..1387
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 2 is encoded by transcript variant 5;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 2"
                     /protein_id="NP_001423618.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPGVS
                     VVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFDPQ
                     PTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTSEL
                     LFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAETLF
                     YVCGPPPMTDFFSKHLESSHVPKEHICFEKWW"
     misc_feature    656..1375
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    656..1375
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(737..739,773..784,833..841,851..862,983..985)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(737..739,773..784,833..841,851..862,983..985)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(773..775,779..784)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(773..775,779..784)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(851..853,860..862,869..871,890..892)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(851..853,860..862,869..871,890..892)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(968..970,980..991,995..997)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(968..970,980..991,995..997)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(983..988,1091..1099,1298..1303)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(983..988,1091..1099,1298..1303)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     exon            739..880
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1123
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1232
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..2171
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gagtccttgt ttatcctgct ttggaagcac cttctagctc
      481 gtcagagcag cactgacatc tgagacagaa aggtggttga gctcattgcc cctcccctgc
      541 agcctgtcaa tcatgcccag actgtagaaa gctaagctgc cacctgaggg tgccgaggcc
      601 tgggaagtag aggatcctca cctttatccc agtcatggct gcagctaagg tgtgtgagat
      661 cactcacgag tctccatcag tgaagagcct ccgtttgctt gttgctgata aagacttttc
      721 cttcaaggct ggccagtggg ttgatttctt catcccagga gtttcagtgg ttggtgggtt
      781 ttcaatttgc tccagtcccc aacagctaga acgagagaga ataatagaat tggcagtgaa
      841 atacacgaac catcctcctg ctgtctgggt tcacaataag tgcacacttg actcagaagt
      901 ggctctcaga gtaggtggag agttcttctt tgaccctcag cccacagatg cccctcgaaa
      961 cctcgtcttg attgctggag gggttgggat taaccccctg ctttctatcc tgcgccactc
     1021 ggcagatctc caccgggacc acaaagaaaa aaggagaggc tatgatatag gaacaataaa
     1081 actgttctac agcgcaaaga acaccagtga actcctgttt aagaaaaata tcctcgactt
     1141 agtacatgag tttcctgaga agattgcctg cagttttcac gttacaaaac agacgaccca
     1201 aatcagttct gaacttaagc cttatgtcac agatggaaga ataacagaga aggagataag
     1261 agagcacatt tcggcagaga ctctgttcta tgtctgcggc ccacctccaa tgacagactt
     1321 tttctctaag catctggaaa gcagccacgt tcccaaggaa cacatctgct ttgagaagtg
     1381 gtggtaggag caggcacaga agacctgaga gccgctcagg acagtgagaa ccagcaacag
     1441 agtcacacga gaaacttccc gcagacttca ttggtggcac tatttttcac tatattgatt
     1501 tttctttcat taattatcct atgatagttc attattacag aatttctgac ctttggggaa
     1561 aagaccatgc tcaacccaat tgtaattaaa agatttactg atgagctgct ggcaggaaga
     1621 caggctgaga gccagatttg agatggccat aaataaaaga gggtgggggg aaaggtttcc
     1681 caaagggaaa accatgggga ggctcacggt atctatgcaa gcaggcagac tctggcctgt
     1741 tctgccaaga ttaagtgggt aaagcaactg gaaacaatct gggtgtctgc acacgcaagt
     1801 tacagaagct gaaaacggcc tccatagcca ggagaagctc acagctgtgc gtttctgggg
     1861 acccctgagc cagggctgtt ttctgggacc ccgtctttct ggaattttga gtctatggcg
     1921 agcagtcatc agtactaaga tggagggagg cctagaaaaa aatagtttct cgagttggcc
     1981 tttacaccac gaactgatta atacaggttt ttcttttgcc ctttgggggc aaattagtct
     2041 aattatgtta attaaaggaa agtgtgggtt ttgtgtgaac tgtatacttc tctaaataat
     2101 tggacagaaa ttcataaaat ttatgtttac tgaatttata attttaaata cattctttat
     2161 tttgaaatgt c
//
LOCUS       NM_001106685            5103 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 3 receptor (Csf3r),
            transcript variant 3, mRNA.
ACCESSION   NM_001106685 XM_001057564 XM_233514
VERSION     NM_001106685.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5103)
  AUTHORS   Zhang,E., Lee,S., Yi,M.H., Nan,Y., Xu,Y., Shin,N., Ko,Y., Lee,Y.H.,
            Lee,W. and Kim,D.W.
  TITLE     Expression of granulocyte colony-stimulating factor 3 receptor in
            the spinal dorsal horn following spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Mol Med Rep 16 (2), 2009-2015 (2017)
   PUBMED   28656207
  REMARK    GeneRIF: the expression of GCSFR in neurons following peripheral
            nerve injury may be involved in the induction and maintenance of
            neuropathic pain through the STAT3 and TRPV1 signaling pathway.
REFERENCE   2  (bases 1 to 5103)
  AUTHORS   Aref,S., El-Ghonemy,M., Abouzeid,T., El-Sabbagh,A. and El-Baiomy,M.
  TITLE     Prevalence and impact of colony stimulating factor 3 receptor
            (CSF3R) mutations among Egyptian acute myeloid leukemia patients
  JOURNAL   Leuk Res 38 (6), 722-725 (2014)
   PUBMED   24746896
REFERENCE   3  (bases 1 to 5103)
  AUTHORS   Fleischman,A.G., Maxson,J.E., Luty,S.B., Agarwal,A., Royer,L.R.,
            Abel,M.L., MacManiman,J.D., Loriaux,M.M., Druker,B.J. and
            Tyner,J.W.
  TITLE     The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in
            mice that is responsive to therapeutic JAK inhibition
  JOURNAL   Blood 122 (22), 3628-3631 (2013)
   PUBMED   24081659
REFERENCE   4  (bases 1 to 5103)
  AUTHORS   Kosmider,O., Itzykson,R., Chesnais,V., Lasho,T., Laborde,R.,
            Knudson,R., Gauthier,A., Merlevede,J., Ades,L., Morabito,M.,
            Fontenay,M., Tefferi,A., Droin,N. and Solary,E.
  TITLE     Mutation of the colony-stimulating factor-3 receptor gene is a rare
            event with poor prognosis in chronic myelomonocytic leukemia
  JOURNAL   Leukemia 27 (9), 1946-1949 (2013)
   PUBMED   23774674
REFERENCE   5  (bases 1 to 5103)
  AUTHORS   Hanumanthu,V.S. and Pirruccello,S.J.
  TITLE     GCSF-R expression in myelodysplastic and myeloproliferative
            disorders and blast dysmaturation in CML
  JOURNAL   Am J Clin Pathol 140 (2), 155-164 (2013)
   PUBMED   23897249
REFERENCE   6  (bases 1 to 5103)
  AUTHORS   Semerad,C.L., Poursine-Laurent,J., Liu,F. and Link,D.C.
  TITLE     A role for G-CSF receptor signaling in the regulation of
            hematopoietic cell function but not lineage commitment or
            differentiation
  JOURNAL   Immunity 11 (2), 153-161 (1999)
   PUBMED   10485650
REFERENCE   7  (bases 1 to 5103)
  AUTHORS   Otsuji,W., Tanase,S., Yoshida,S. and Bawden,J.W.
  TITLE     The immunohistochemical localization of the interferon-gamma and
            granulocyte colony-stimulating factor receptors during early
            amelogenesis in rat molars
  JOURNAL   Arch Oral Biol 44 (2), 173-181 (1999)
   PUBMED   10206335
REFERENCE   8  (bases 1 to 5103)
  AUTHORS   Hermans,M.H., Ward,A.C., Antonissen,C., Karis,A., Lowenberg,B. and
            Touw,I.P.
  TITLE     Perturbed granulopoiesis in mice with a targeted mutation in the
            granulocyte colony-stimulating factor receptor gene associated with
            severe chronic neutropenia
  JOURNAL   Blood 92 (1), 32-39 (1998)
   PUBMED   9639496
REFERENCE   9  (bases 1 to 5103)
  AUTHORS   Dong,F., Dale,D.C., Bonilla,M.A., Freedman,M., Fasth,A.,
            Neijens,H.J., Palmblad,J., Briars,G.L., Carlsson,G., Veerman,A.J.,
            Welte,K., Lowenberg,B. and Touw,I.P.
  TITLE     Mutations in the granulocyte colony-stimulating factor receptor
            gene in patients with severe congenital neutropenia
  JOURNAL   Leukemia 11 (1), 120-125 (1997)
   PUBMED   9001427
REFERENCE   10 (bases 1 to 5103)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001106685.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000005.1  143583210-143583275
            67-157              JAXUCZ010000005.1  143584764-143584854
            158-241             JAXUCZ010000005.1  143586042-143586125
            242-541             JAXUCZ010000005.1  143588148-143588447
            542-665             JAXUCZ010000005.1  143590265-143590388
            666-853             JAXUCZ010000005.1  143590587-143590774
            854-1023            JAXUCZ010000005.1  143592025-143592194
            1024-1177           JAXUCZ010000005.1  143592279-143592432
            1178-1257           JAXUCZ010000005.1  143593262-143593341
            1258-1471           JAXUCZ010000005.1  143593661-143593874
            1472-1654           JAXUCZ010000005.1  143594985-143595167
            1655-1756           JAXUCZ010000005.1  143595483-143595584
            1757-1903           JAXUCZ010000005.1  143597332-143597478
            1904-2044           JAXUCZ010000005.1  143597586-143597726
            2045-2135           JAXUCZ010000005.1  143600615-143600705
            2136-2217           JAXUCZ010000005.1  143600867-143600948
            2218-5103           JAXUCZ010000005.1  143601497-143604382
FEATURES             Location/Qualifiers
     source          1..5103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5103
                     /gene="Csf3r"
                     /note="colony stimulating factor 3 receptor"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
     exon            1..66
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            67..157
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Csf3r"
                     /note="upstream in-frame stop codon"
     exon            158..241
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2694
                     /gene="Csf3r"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; granulocyte colony-stimulating factor receptor;
                     colony stimulating factor 3 receptor (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     isoform a precursor"
                     /protein_id="NP_001100155.1"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
                     /translation="MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLA
                     SCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFC
                     LVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKL
                     CIDPMDVVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQECELRYQPQLE
                     GANWTLVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWSPGLQLRPTIKA
                     PTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCPDGQGRIMHLCN
                     TTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLHAMAQDLGSIWV
                     DWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHPFQLYRITVAPL
                     YPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIF
                     WTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNSTGLTLMTMALDS
                     SDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLSAWVPTIMTEET
                     FQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAYVLQGDPREISN
                     QFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPKSYENIWFHSRP
                     QETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     sig_peptide     178..252
                     /gene="Csf3r"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    247..510
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    247..510
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    544..840
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    544..840
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    1474..1740
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1474..1740
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1714..1719,1723..1728)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1714..1719,1723..1728)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1762..1764,1954..1956,1999..2001)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1762..1764,1954..1956,1999..2001)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    1771..2004
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1771..2004
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     exon            242..541
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            542..665
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            666..853
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1023
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1177
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1257
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1471
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1654
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1756
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1903
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2044
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2135
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2217
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..5103
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggagag gagacaagag aagagagagc aaacgtgggg gctgggcaca gcgccccagc
       61 cccaatcatt gctgagacat gagcataagc cccttttccc aaatggagaa attgagactc
      121 agaaaggtga agtaacccat ccaagttcac caggcaggta aacaccaagc tggcgaaatg
      181 gtggggctgg gagcctgcaa cctgactgga gttaccctga ttgtcttgct actccccaga
      241 agtctggagg gctgcgggca aatcaggatc tcacccccca ttgtccatct tggggatcct
      301 gtcctggcct cctgcaccat cagcccaaac tgcagcaaac tggaccgaca gccaaagatc
      361 ctatggagac tgcaagatga accaaaccag cctggggaca gacagcatca cctgcctgac
      421 gggtcccagg agtccatcat cactctgcct catctgaact acactcaggc cttcctcttc
      481 tgcttggtgc catggaacaa cagcttccag gtcctggatc aagctgagct tcgtgcaggc
      541 tatcctcctg ccagcccctc caacctatcc tgcctcatgt acctcaccac caacagcctg
      601 gtctgccagt gggagccagg ccccgagacc cacctgccca ctagcttcat cctaaagagc
      661 ttcaggagcc gcaccggctg tcagtaccag gggggcacca tcctggactg tatgcccaag
      721 aagagacaca gcaactgctc catcccccgc aaacacttgc ttctgtacca gaatatggtc
      781 atctgggtgc aagcggagaa tatgctaggg tccagcgagt ccccaaagct gtgcattgac
      841 cccatggatg ttgtgaaatt ggagcctccc atgctgcagg ccctggacat tggccatgat
      901 atagtctctc gccagcctgg ctgcctatgg ctgagctgga agccatggaa gcccagtgag
      961 ttcatggagc aggagtgtga actccgttac cagccacagc ttgaaggagc caactggacc
     1021 ctggtgtccc acctgccttc cagcacggac cggttcgagc tctgcagcct tcatcaagcc
     1081 ccagtctaca ccctacagtt gcgatgcatc cgctcatctc tgcctggact ctggagcagc
     1141 tggagccctg gccttcagct gaggcccacc attaaggccc ccaccatcag actggacaca
     1201 tggtggcaga agaagcatct ggatcctgag acagtgagaa tgcagctgtt ctggaagcca
     1261 acacccctgc agaaagacag tggacagatc cagggctacc tgctctcctg gagttgccca
     1321 gatgggcaag ggcggatcat gcacctctgt aacaccacag agctcagctg caccttccac
     1381 ctgccctcag aggcccagaa cgtgaccctt gtggcctaca actcggcggg gacctcctcc
     1441 cctactctgg tggttttcct ggagcacgaa ggtccagctg tgaccagcct gcatgccatg
     1501 gcccaagacc ttggtagcat ctgggtagac tgggaagccc ccagccttct gcctcagggc
     1561 tatctcattg agtggggccc ggattcccac aaatacagca ataattcctg gaggatagag
     1621 cccaatggga acaccactgg aattctgtta gaggacaata tacatccctt tcaactctac
     1681 agaatcacag tggctcccct gtacccaggc accgtgggac cccctgtaaa tgtctacacc
     1741 tactctggag agaaagccct tcctcatgct ccagagctat atctaaagca tgttggcagg
     1801 acctgggcac agttggagtg ggtacctgag accccttggc tggggatgat acccctcacc
     1861 aactacacca tcttctggac cgatgctcgg gaccactcct tctctgtcac cctgaacatc
     1921 tcctttcatg actttgtcct ggaccacctg aaacctgcca gtttgtatca cgtctacctc
     1981 atggccacca gccgggcagg gtccaccaac agtacaggcc ttaccctgat gaccatggcc
     2041 ctagattcat ctgatgtaaa cattttcctg ggcatacttt gcttcgtact tttgtccatt
     2101 acctgtgcaa ctgcctggtt ctgctgcaag caaagcagaa agactttctt ctggccaaat
     2161 gtgccagacc cagcccacag cagtctgagc gcctgggtgc ccaccatcat gacagaggaa
     2221 accttccagc tgcccagctt ctggggctcc agtgtgccgt caatcaccaa gatcactgaa
     2281 ctggaggagg acaagaaacc gacccactgg gatcccagtg agagctctgg gactgggagc
     2341 cttccagccg tggttcaggc ttacgtgctc caaggagacc caagagaaat ttccaaccag
     2401 ttccagcctc cctctagcac taatgaccag gttctctatg gtcaggtgct tgggagcccc
     2461 accagcccag aagtagtggg ataccttcgg tgtgactcca ctcagcccct cttgggaggc
     2521 cccacaccca gccctaaatc ctatgaaaac atctggttcc attcaagacc ccaggagacc
     2581 tttatacccc aacctccaag ccaggaagat gactgtgtct ttggacctcc atttgatttc
     2641 cccctcttcc aggggctcca ggtccatgga gttgaagaac aagggggttt ctaggacttt
     2701 tggggtcctt acatcctgaa ggccctggcc tattcaggaa agatcccacc actaatatct
     2761 actggtcctg agggaaacag aaaggcccta tttgtctcca gctgtggccc ctaggacctc
     2821 tccttcactc taacctccac aggctacacc cctaggtctt tctcacactc caaggtccag
     2881 atacatactg tttacagccc actagtcacc ttgtgtctct catataattt cagtccgtta
     2941 aactgagtgt aggttttgag cagggactag cacgttcaca aatcctggct ggacgtagtg
     3001 atacatgcct agcatcccaa ctcaaacgtt tgggaggaag atgcaggagg attgcaagtt
     3061 ccaggccagc ctgggctata tgaagagatc ctgcctcaga aattaagcaa aagccaaata
     3121 aaattttttt attacattta ctttttgttg gtggggttgg gggctcacag gcaaaggtca
     3181 gacaccttaa gggaattaac tctggcctcc agcctgtgga ttttgggagg tgaacgtaag
     3241 gtttagtggc aagcatcttt ccccagggag gcatttcact agtcccagag aggagtctct
     3301 taagtatagc taagtgtctt ttacacttgt ctgtctgtct gtttttcaaa aaaaggtttc
     3361 tctgtgtacc tgtcctatct gtcctggaac tcactctgta gaacaggctg gcctcaaact
     3421 cagagatcca cctgcctctg tcttctgaat ggtgggaata aaggcctgca caccaccacc
     3481 cagcagtgtc atttcctctc agggcccagc agtcatgaag ctatttctca gtcagtcatc
     3541 tgttccgttc cttccctcct cttcctcctt ccttccttcc ctcccttcct ctttccttcc
     3601 ttccttcctt ccctccctcc ctccctccct ccttccttcc ttccttcctt ccttccttcc
     3661 gtcctcttgc ctagcatcta agattcaaaa gagacaaccc ccatagacag ctgctatact
     3721 ggcaatgggg tcttaaaact gataatcaga aaacaagcaa gagcttcttg gaaggaactg
     3781 gagtgttagg gaacacagac ctgggaagag aggagccctg ctgcagctgc tgctgctgca
     3841 atcccaacat gtgagaggct gaaacaggaa ggctgtccat ttgaggttaa gttgtgatac
     3901 acagcaagtc aagagcctct ctctgcttct gcctctctcc ctctttgtgt atctgtctgt
     3961 ttcttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttgttg
     4021 attggttttg gactttttcc ccttggggag actccaatac cgatttctgt ggtgattaca
     4081 cacacattcc cagtagcaat gtagaagaac gttttcagct atgctcacgc ctttaatcac
     4141 agcactcagg aggcagaaga aagcagatgt ctgagtttga gccagcctgg tctacagagt
     4201 gagtaaattc caggataccc agggctatca aacaaacatt tcttgtcact cagggtcttg
     4261 gtgacagtca tttctcctgg ggtgagatgg catttcaatg tatttttcaa tttgcatttc
     4321 cattgtggcc aggtgtgttg aatatttttt ccaatatcta ttaacaattc tttttttatt
     4381 attattaaat ttacttaatt tctatttttt attcatttat tatatataag tacactgtag
     4441 ctgtcttcac atacaccaga agagggtaac agatctcttt acagatggct gtgagccacc
     4501 atgtggttgc tgggaattga actcaggacc tctggaagag cagtcgggtc tcttaaccac
     4561 tgagccgtct ctccagcccc tattaacaat tcttatctct tcttttggga agtatctgac
     4621 caattcattt gtccatgtat tgaccaacga tctggtattg ggaatttaaa tactggagtt
     4681 ccttgtataa tatacataat tccattagat aatttttttt ttggttcttt ttttcggagc
     4741 tggggaccga acccagggcc ttgcacttcc taggcaagcg ctctaccact gagctaaatc
     4801 cccaaccccc tccattagat aattaactgg tcaaattttc tcccattctg attgccccac
     4861 acacatgtag agacgaaagg ttgaactctc cgtggttgtc agtttgcctt gtcttgtttt
     4921 gttttggaga cagaatttca ctagttctga ctggcctgaa acttgctagg taaaccaggc
     4981 tggcctcaaa ctcaccgaga tatccccctg cctctgcctc ctaagtgctg agactaagac
     5041 aagtgctacc atgcccatcc accctacttt ttcttttatt aaatatttgc ttattttctt
     5101 gtg
//
LOCUS       NM_001436660             930 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 2, mRNA.
ACCESSION   NM_001436660
VERSION     NM_001436660.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.681793.1,
                                           SRR26360181.1553161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000016.1  43955989-43956211   c
            224-353             JAXUCZ010000016.1  43955091-43955220   c
            354-472             JAXUCZ010000016.1  43954509-43954627   c
            473-693             JAXUCZ010000016.1  43954179-43954399   c
            694-930             JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..930
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..223
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..842
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 2"
                     /protein_id="NP_001423589.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MAAAGRAEESLPLPAAESSKTTLPTPPAVPAARKPKKCLVYPHP
                     PRSSRLCPSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTS
                     LKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQ
                     DDFANFTDYSYQMRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQML
                     QRKLSRKLNPAKSGNDVQPHREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSC
                     H"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     exon            224..353
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..472
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..693
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..930
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac cagggatttt tcaaatggct
      241 acctagttgc agagatattc tgtatatatt acccctggga ccttcgatta tcatcctttg
      301 aaaatggtac ttccttgaaa gtcaaattgg ataactgggc acaaatagag aagtttctag
      361 cgaaaaaaaa atttaaacta cctaaagaac tcatccatgg aacaattcac tgtaaggctg
      421 gggtgcctga aatactgatt caggagattt acactttact cacccatcaa gaaattagaa
      481 gcatccagga tgattttgct aatttcacag actatagtta tcagatgcgt ttgcccctgg
      541 ttcccaggag tacagtatca aagtctatta aaaataacat taggttatcg gaactactaa
      601 gcaatcctaa tattctcagc aatgaactca agatagaatt cctcttcctt ttgcaaatgc
      661 tgcaaagaaa attaagcaga aaattgaatc cagcaaaatc aggcaatgat gtccaaccac
      721 atagagaaat ccatgtgaag caaaatggaa aaccttgtga tgccactgca aaacctatga
      781 taaatgtgga agaaacaatg aaagacacgg aggaagtagc tttgaagaag tcatgtcatt
      841 aatgtctacc acaatctggg tatataatga cacacccagt cttggatgta tttaaataat
      901 aaataactta acttggtgtc ttaaccataa
//
LOCUS       NM_001436708            3090 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 5, mRNA.
ACCESSION   NM_001436708 XM_063287433
VERSION     NM_001436708.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3090)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3090)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3090)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3090)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3090)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3090)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287433.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.20697.1,
                                           SRR26643290.20304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2289           JAXUCZ010000005.1  140860181-140860252
            2290-2376           JAXUCZ010000005.1  140860729-140860815
            2377-2504           JAXUCZ010000005.1  140860911-140861038
            2505-2598           JAXUCZ010000005.1  140862618-140862711
            2599-2729           JAXUCZ010000005.1  140862797-140862927
            2730-2789           JAXUCZ010000005.1  140863198-140863257
            2790-3090           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3090
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2807
                     /gene="Pabpc4"
                     /note="isoform 5 is encoded by transcript variant 5;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 5"
                     /protein_id="NP_001423637.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVPNLAP
                     RATVAAAAPRAVAPYKYASNVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQE
                     QKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQ
                     AHHAKKEAAQKESKAK"
     misc_feature    915..2756
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2756
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2289
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2376
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2504
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2598
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2729
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2789
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..3090
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg gtctgagtgc ccggaccgct tggctatgga ctttggtggg gctggtgccg
     2341 cccagcaagg gctgactgac agctgccagt ctggaggcgt ccctacggct gtgccaaacc
     2401 ttgcacctcg tgctacagtc gctgctgctg ctcccagggc tgtggctcca tacaagtatg
     2461 cctccaatgt ccgcagccct caccctgcca ttcagccgct gcaggccccc cagcctgcag
     2521 tccatgtcca gggtcaagaa cccctgactg cctccatgct ggctgcagct cctccccagg
     2581 agcagaagca gatgctgggg gagcgtttgt tcccacttat ccaaacaatg cattcaaacc
     2641 tggctggaaa aattacaggg atgctgctag aaatcgacaa ctctgagctg ctccacatgc
     2701 tggagtcccc cgagtccctc cgttccaagg tggatgaagc tgtggcagtc ctgcaggctc
     2761 atcatgccaa gaaagaagct gcccagaagg agtcaaaagc caaataaccc ctcacggcat
     2821 tcagctgagg tctgaagact tcctagtttg tctgtggacc tctttcaaga accaagttac
     2881 aaattcaaca ggtcattttg tatcaaaagg tcaattatga agcacctaga atttttcaat
     2941 tataagaata tattctctgg gttctgttgt ggcccagatg atggtaactt ttttttctat
     3001 tatgagttct gttttttttc ccctctccca gaaattggtt ttgatgtacc caagacttaa
     3061 gtttctcaat aaaggaaata aaatctccaa
//
LOCUS       NM_001436711            3003 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 8, mRNA.
ACCESSION   NM_001436711 XM_063287434
VERSION     NM_001436711.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287434.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20003.1,
                                           SRR26643296.15990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2289           JAXUCZ010000005.1  140860181-140860252
            2290-2417           JAXUCZ010000005.1  140860911-140861038
            2418-2511           JAXUCZ010000005.1  140862618-140862711
            2512-2642           JAXUCZ010000005.1  140862797-140862927
            2643-2702           JAXUCZ010000005.1  140863198-140863257
            2703-3003           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3003
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2720
                     /gene="Pabpc4"
                     /note="isoform 8 is encoded by transcript variant 8;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 8"
                     /protein_id="NP_001423640.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGVPTAVPNLAPRATVAAAAPRAVAPYKYASNVRSPHPAIQ
                     PLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLL
                     EIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKESKAK"
     misc_feature    915..2669
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2669
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2289
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2417
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2511
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2642
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2702
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..3003
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg cgtccctacg gctgtgccaa accttgcacc tcgtgctaca gtcgctgctg
     2341 ctgctcccag ggctgtggct ccatacaagt atgcctccaa tgtccgcagc cctcaccctg
     2401 ccattcagcc gctgcaggcc ccccagcctg cagtccatgt ccagggtcaa gaacccctga
     2461 ctgcctccat gctggctgca gctcctcccc aggagcagaa gcagatgctg ggggagcgtt
     2521 tgttcccact tatccaaaca atgcattcaa acctggctgg aaaaattaca gggatgctgc
     2581 tagaaatcga caactctgag ctgctccaca tgctggagtc ccccgagtcc ctccgttcca
     2641 aggtggatga agctgtggca gtcctgcagg ctcatcatgc caagaaagaa gctgcccaga
     2701 aggagtcaaa agccaaataa cccctcacgg cattcagctg aggtctgaag acttcctagt
     2761 ttgtctgtgg acctctttca agaaccaagt tacaaattca acaggtcatt ttgtatcaaa
     2821 aggtcaatta tgaagcacct agaatttttc aattataaga atatattctc tgggttctgt
     2881 tgtggcccag atgatggtaa cttttttttc tattatgagt tctgtttttt ttcccctctc
     2941 ccagaaattg gttttgatgt acccaagact taagtttctc aataaaggaa ataaaatctc
     3001 caa
//
LOCUS       NM_001436674            3437 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 4, mRNA.
ACCESSION   NM_001436674
VERSION     NM_001436674.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3437)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3437)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3437)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3437)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3437)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2805240.1,
                                           SRR26360181.2926274.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000016.1  6453402-6453566
            166-254             JAXUCZ010000016.1  6453778-6453866
            255-387             JAXUCZ010000016.1  6454871-6455003
            388-507             JAXUCZ010000016.1  6455366-6455485
            508-569             JAXUCZ010000016.1  6455976-6456037
            570-712             JAXUCZ010000016.1  6456213-6456355
            713-791             JAXUCZ010000016.1  6456604-6456682
            792-915             JAXUCZ010000016.1  6457065-6457188
            916-1063            JAXUCZ010000016.1  6457443-6457590
            1064-1248           JAXUCZ010000016.1  6458022-6458206
            1249-1376           JAXUCZ010000016.1  6458575-6458702
            1377-1855           JAXUCZ010000016.1  6459242-6459720
            1856-2016           JAXUCZ010000016.1  6459835-6459995
            2017-2109           JAXUCZ010000016.1  6460240-6460332
            2110-2182           JAXUCZ010000016.1  6460433-6460505
            2183-3437           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3437
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..165
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    130..132
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     exon            166..254
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..387
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..2316
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 4;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 3"
                     /protein_id="NP_001423603.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFS
                     PESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF
                     ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRV
                     KYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLE
                     AGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQ
                     RLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSA
                     IRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGS
                     PAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVL
                     FGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSS
                     QGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYE
                     ACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS
                     IGRLHKQRKPDRRKRSRPYKAKRQ"
     misc_feature    <370..831
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    <370..831
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    order(385..387,403..405,637..639,682..684)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(385..387,403..405,637..639,682..684)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(385..387,403..405,637..639,682..684)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(385..387,403..405,637..639,682..684)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    2053..2190
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2053..2190
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     exon            388..507
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..569
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..712
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..791
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..915
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1063
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1248
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1376
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1855
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2016
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2109
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2182
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..3437
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgt ggggctgaga agccccgagg gcggtgggcg
       61 ctcccggtgg gggcggcgcg gggttagcag ggcctggaca tggcgctgag agaccgctcc
      121 gcgggaagat gaataagggc tggctggagc tggagagtga cccgggctgc cctgccgacc
      181 tctccttttc tgattgtagg tgtcaaaggg gtgcaagtgg aggagatcta tgaccttcag
      241 agtaaatgcc aggggcctgt atatggattt atcttcctgt tcaaatggat cgaagagcgc
      301 aggtcccgcc gcaaggtttc tacgttggtg gatgatacat ctgtgattga tgatgacatc
      361 gtgaatagca tgttctttgc tcaccagctg attcccaact cttgtgccac tcacgccttg
      421 ctgagcgtgc ttctgaactg cagcaatgtg gatttggggc ccacgctgag tcgaatgaag
      481 gatttcacca aaggcttcag ccctgagagc aaaggatatg cgattggcaa tgcccctgaa
      541 ctggccaagg cacataatag ccatgccagg ccagaaccac gtcaccttcc tgagaaacag
      601 aatggcctca gtgcagtgcg gaccatggag gcgtttcact ttgtcagcta tgtgcctatc
      661 acaggacggc tctttgaatt ggatgggttg aaagtctacc ctattgatca tgggccctgg
      721 ggagaggatg aggagtggac agataaagcc cgaagggtca tcatggagcg aatcggcctt
      781 gctactgcag gggagcccta ccatgacatt cgcttcaacc tgatggcagt ggtgcctgac
      841 cgcagggtta agtatgaggc caggctgcat gtgctgaagg ggaaccgaca aacagtcctg
      901 gaggccctgc agcagctgat tagagtaaca cagccagagc tgattcagac ccacaaatct
      961 caagagtcac aactgcctga ggagagcaag ccagccagca gcaagtctcc ctttgggcta
     1021 gaggcgggca gaaccccggc ggcctctgag tgcactcaca cagatggtgc agaggaggtg
     1081 gctggttcgt gcccacaaac tacaacccat agtcctccca gcaaatctaa gctggtggtg
     1141 aagccttcag ggagcagcct caatggggtt cccccaaccc ctacccctat tgtccagcgg
     1201 ctgccagcct ttctagataa tcacaattat gccaaatccc ctatgcagga ggaggaagac
     1261 ctggcggcag gtgtgggccg cagccgagtt ccagtccgac cccagcagta ctctgatgat
     1321 gaggaggact atgaggatga ggaggaggat gtgcagaata ccagttctgc catcagatac
     1381 aagcggaagg ggacagggaa gccaggatcg ttgagcaatt cttcagatgg gcagctgtca
     1441 gtgctgcagc ccaacaccat caatgtctta actgagaagc ttcaagagtc tcagaaagac
     1501 ctttcaattc ctctgtccat caagactagc agtggggctg ggagtccagc cgtggctgtg
     1561 cccacacact cgcagccttc acccacccct agcaatgaga gcacggacac agcctctgag
     1621 attggcagtg ctttcaactc acccttgcgc tcacccatcc gctcagccaa cccaacacgg
     1681 ccctctagcc ctgtcacctc tcacatctcc aaggtgctct ttggagaaga tgacagccta
     1741 cttcgtgttg actgcatacg ctacaaccgt gctgtccgtg acctgggtcc tgtcattagc
     1801 acgggcctgc tgcaccttgc tgaggatggt gtactgagtc ccctggcact cacagagggt
     1861 gggaagggtt cctcaccttc taccagatca agccaaggca gccaggggtc cagcagccta
     1921 gaggagaagg aggtggtgga agtcacagat agcagagaca agtctgggct gaacaggtcc
     1981 agtgagccct tgagtggaga gaagtactcg cccaaggagc tgttagcact gttaaagtgt
     2041 gtagaggccg agattgcaaa ctatgaggcc tgtctcaagg aggaggtgga gaaaaggaag
     2101 aagttcaaga ttgatgacca gcgaaggacc cacaactatg atgagttcat ctgcaccttc
     2161 atatccatgc tggctcagga aggaatgctg gccaacctgg tggagcagaa catctcagtg
     2221 cggcgccgcc aaggggtcag cattggtcgg cttcacaagc agcggaagcc tgataggcgg
     2281 aaacgctctc gcccctacaa ggccaaacgc cagtgaggac ctctagccct gactctgcag
     2341 cctctcttgc cgcaaggccc tcaccagggc ccttcactgt tcgacttttc caagtattac
     2401 tgaatagttc agctagagct caggccctgg gagtaggaat gggatgtgta ttctgcatta
     2461 tgctctgggg tctggcaggg acaaggcagc tccataatgc tcaggaagca gcagctggaa
     2521 ttggagggtg ctgtggcctc cacggccatc tgaggagcag caggatatat attctacctg
     2581 ttggagatgt ctattttttt gacttttggc catcttgcca ctgtattaac atggccagct
     2641 tcctgactct gctttctctc ccagcagctg tcattctgct gggcccaggt ctcttataac
     2701 cacagtacca gctgggaaac ccagaaggca ttggtcctgg tgctctagca ccagccacca
     2761 gcctgtcctt gttgtgaaga agcttggcct actactcttg attccttctg ggagagcgcc
     2821 aaactcaggg acctggctgc tgagctggaa tgggcatggg gtatcctagt aggatgtaca
     2881 gcctatcagg gtcccacagc tatcgtggag acaagtgttt gaactgtcct cgtaccaccc
     2941 agacttgtta gtgagtcaga gcagggctct ggggctcttt gccttcagtg ttgtggccct
     3001 ggccgtgggc ctaccttagg ctcctaatct ccgtctctgg ggtccagagg agccactact
     3061 tagcccctca gtattaccat gtctcctctt aggaatgtca gaggcagggc tgctcgaatg
     3121 aggctggcac tattcaattc tcccgaccgt gccagcttcc ttggcctcat gcaggtactc
     3181 agggtagggg acagggtcaa gaggagttag aacttctgtg ttcccatagg gcttgatgcc
     3241 agtggggtag taagcacagc actgcttcaa gctccaggcc cagatagccc tgtgccctct
     3301 gctagataca ggtgatccaa gcaggcccct tacctgtaca tagcaactgt cggggggatg
     3361 gtacagcagt ccgacccgct atagtgtctg taaatactga atcagtgagt gaagaataaa
     3421 agtgtgctaa taagtga
//
LOCUS       NM_001436699            2135 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 6, mRNA.
ACCESSION   NM_001436699 XM_006238647
VERSION     NM_001436699.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238647.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1085866.1,
                                           SRR26360194.182772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000005.1  135319012-135319175 c
            165-212             JAXUCZ010000005.1  135314949-135314996 c
            213-323             JAXUCZ010000005.1  135311284-135311394 c
            324-404             JAXUCZ010000005.1  135306753-135306833 c
            405-514             JAXUCZ010000005.1  135304577-135304686 c
            515-594             JAXUCZ010000005.1  135298279-135298358 c
            595-680             JAXUCZ010000005.1  135297655-135297740 c
            681-754             JAXUCZ010000005.1  135297473-135297546 c
            755-943             JAXUCZ010000005.1  135296880-135297068 c
            944-1110            JAXUCZ010000005.1  135296609-135296775 c
            1111-1167           JAXUCZ010000005.1  135296062-135296118 c
            1168-1245           JAXUCZ010000005.1  135295896-135295973 c
            1246-1374           JAXUCZ010000005.1  135295084-135295212 c
            1375-2135           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2135
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..164
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1455
                     /gene="Nasp"
                     /note="isoform c is encoded by transcript variant 6;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform c"
                     /protein_id="NP_001423628.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDETEGSEEEDKENDKAEETTNESVL
                     EKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN
                     YIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIE
                     KRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKAT
                     LVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDD
                     AKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     misc_feature    109..111
                     /gene="Nasp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    202..204
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    232..333
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    451..486
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    472..474
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    484..486
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    619..690
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    619..690
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    706..936
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    706..936
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    712..825
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    712..825
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    712..798
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    712..798
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(715..717,724..729,736..741,745..747,841..843,
                     850..855,862..867,871..876,937..939,946..951,958..960)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(715..717,724..729,736..741,745..747,841..843,
                     850..855,862..867,871..876,937..939,946..951,958..960)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    811..927
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    811..927
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            165..212
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            213..323
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            324..404
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            405..514
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..594
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            595..680
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            681..754
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            755..943
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1110
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1167
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1245
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1374
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2135
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatctgcc attttctcta cctgagtaag tcatcgttgt ctggaattct ctcgttttct
       61 tcgcaggcag tatactgccc actggcccac cacctcaggg gaacgatggc cacagagtct
      121 acagccactg ctgccatcgc cgcggaactg gtttccgctg acaaagttga agatgctcct
      181 gctccttcta cctctgcaga taaaatggag agtctggatg tggatagtga agctaagaaa
      241 ctactgggat taggacagaa acatctggtg atgggtgaca ttccagcagc tgttaatgca
      301 ttccaagaag cagctagtct tttaggtaag aagtatggag aaacggctaa tgagtgtgga
      361 gaagccttct ttttttatgg gaagtcactt ctggagttgg ccagaatgga gaatggagtg
      421 ttgggaaatg ccttagaagg agtgcatgta gaagaggaag aaggagaaaa aacagaagat
      481 gaatctttgg tagaaaataa tgataatgta gatgaaactg aaggctcaga ggaagaagac
      541 aaagaaaatg acaaggctga agaaacaaca aatgaatcag ttcttgaaaa aaagactctt
      601 caagaaaatg aagaagagga gattgggaat ttagaacttg cctgggatat gctagattta
      661 gccaagatta tttttaagag gcaagaaaca aaagaagccc agctttatgc tgcacaagcc
      721 catcttaaac ttggagaagt tagtgttgaa tctgagaatt atatccaagc tgtggaggag
      781 tttcaggctt gcctaagcct gcaagagcag tatttggaag ctcacgatcg tctccttgcg
      841 gagactcact accagttggg tttggcctat ggttacaact ctcagtatga tgaggctgta
      901 gcacagtttg gcaaatctat tgacgtcatt gagaagagaa tggctgtact acttgagcag
      961 atgaaggagg ctgaaggatc atttactgaa tacgagaaag aaatcgagga gctgaaagaa
     1021 ctgctccccg agattcggga gaagatagag gatgcaaagg agtctcagcg gagtgggaat
     1081 gtagctgagc tggctctgaa ggccactctg gtcgagagct ctacttcagg tttcactcct
     1141 agtggagctg gtgcctcggt atccatgatt gccagtagaa aaccaacaga tggcgcttcc
     1201 tcatcaaact gtgtcactga tatttctcat cttgtcagaa agaagaggaa accagaggaa
     1261 gagagtcccc ggaaagatga tgcaaagaaa gctaaaccag aaccagaggt gaatggaggc
     1321 agtggagatg ctgtctccag tggaaatgaa gtttcagaaa acatggaggc agaggctgag
     1381 aatcaggctg agagccagac aacagcagaa gggacagtgg actctgcagc tacagttaaa
     1441 agcactgcat gttaagaggc gagcagaacc ttcctcctga gggaaagtgg ttttgtacat
     1501 aatgtatttt ttcacttttg gggattcttt ttgtataact ccaataaaga ttgtaggcaa
     1561 cagctgagac tttgatggct tttttcttaa aaatattggt ggattgtttt ggggcactct
     1621 atattgtgta tacatgcctt gtgttttgct actgcacaac ccacttcctg tctaatgtgg
     1681 aggtgatcaa gttgatcaag gcccttcatc tactggtgct atgtttctat ttccaaatat
     1741 ttggctgaat tcaaatacct tgtaagcttt ccatggtgct gtccctggat ggggtctgct
     1801 aaacaagaac tggtagaaat cagtttggtg ctgaaaatgg agcatggaat atgacccagg
     1861 tcttggtttg tgcctacctt ctgttcacct ggtttccatt taaggccata atatcctgcc
     1921 ctggcaaaac tggcagaaac atgggaaatg attcctgagg aaaactgttg ttagatactc
     1981 cgtaggatca cactgtagtg ggagacaagt agaagactat gattgagaag tctgttacgt
     2041 tattttctgt atagaaagat tacaatatgt caataagtgg aattgttata ttgtgcagtt
     2101 ttgtctataa aaataaatat gctaatttta acaaa
//
LOCUS       NM_001002852            1068 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 6, mRNA.
ACCESSION   NM_001002852 XM_224832
VERSION     NM_001002852.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1068)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1068)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 1068)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001002852.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY653229.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000016.1  43955989-43956211   c
            224-353             JAXUCZ010000016.1  43955091-43955220   c
            354-472             JAXUCZ010000016.1  43954509-43954627   c
            473-714             JAXUCZ010000016.1  43954158-43954399   c
            715-831             JAXUCZ010000016.1  43950649-43950765   c
            832-1068            JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1068
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..223
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..980
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 6 is encoded by transcript variant 6;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 6"
                     /protein_id="NP_001002852.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MAAAGRAEESLPLPAAESSKTTLPTPPAVPAARKPKKCLVYPHP
                     PRSSRLCPSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTS
                     LKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQ
                     DDFANFTDYSYQMRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQML
                     QRKLSRKLNPGKPSLEKGWFDIKPTVGEITVGHLPAHSYKHKYKSKVSKERAVSSLSK
                     SGNDVQPHREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSCH"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     exon            224..353
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..472
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..714
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..831
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1068
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac cagggatttt tcaaatggct
      241 acctagttgc agagatattc tgtatatatt acccctggga ccttcgatta tcatcctttg
      301 aaaatggtac ttccttgaaa gtcaaattgg ataactgggc acaaatagag aagtttctag
      361 cgaaaaaaaa atttaaacta cctaaagaac tcatccatgg aacaattcac tgtaaggctg
      421 gggtgcctga aatactgatt caggagattt acactttact cacccatcaa gaaattagaa
      481 gcatccagga tgattttgct aatttcacag actatagtta tcagatgcgt ttgcccctgg
      541 ttcccaggag tacagtatca aagtctatta aaaataacat taggttatcg gaactactaa
      601 gcaatcctaa tattctcagc aatgaactca agatagaatt cctcttcctt ttgcaaatgc
      661 tgcaaagaaa attaagcaga aaattgaatc caggtaagcc ttccctggag aaagggtggt
      721 ttgatatcaa accaacagtg ggagaaatca cagttggcca tcttcctgcc catagctata
      781 agcacaaata caaatcaaaa gtttcaaagg aaagagctgt gtcgtcttta tcaaaatcag
      841 gcaatgatgt ccaaccacat agagaaatcc atgtgaagca aaatggaaaa ccttgtgatg
      901 ccactgcaaa acctatgata aatgtggaag aaacaatgaa agacacggag gaagtagctt
      961 tgaagaagtc atgtcattaa tgtctaccac aatctgggta tataatgaca cacccagtct
     1021 tggatgtatt taaataataa ataacttaac ttggtgtctt aaccataa
//
LOCUS       NM_001436717            2430 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1-like (Mtfr1l),
            transcript variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001436717
VERSION     NM_001436717.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2430)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.30775.1,
                                           SRR26643295.23150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000005.1  152029802-152029960 c
            160-285             JAXUCZ010000005.1  152027744-152027869 c
            286-390             JAXUCZ010000005.1  152027268-152027372 c
            391-500             JAXUCZ010000005.1  152025746-152025855 c
            501-712             JAXUCZ010000005.1  152025303-152025514 c
            713-1034            JAXUCZ010000005.1  152024076-152024397 c
            1035-2430           JAXUCZ010000005.1  152020175-152021570 c
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2430
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="mitochondrial fission regulator 1-like"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
     exon            1..159
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            160..285
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    196..198
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="upstream in-frame stop codon"
     CDS             271..1140
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="isoform a is encoded by transcript variant 4;
                     protein FAM54B; family with sequence similarity 54, member
                     B"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1-like isoform
                     a"
                     /protein_id="NP_001423646.1"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
                     /translation="MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPN
                     ISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVP
                     NLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSSG
                     SSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTT
                     CSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRK
                     FALKEEDISRKGN"
     misc_feature    289..1020
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    289..1020
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    349..351
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    382..384
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    568..570
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    589..591
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    931..933
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    934..936
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    973..975
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    1042..1044
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    1078..1080
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     exon            286..390
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            391..500
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            501..712
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1034
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..2430
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcccggg tgtccgccag gcaccgctgg gcaaaagttt ctcagtggcc caggactgtc
       61 gggtcgaggc ccttctcgga acagagaggg tctgccgaga gagtccgcac gtaaagacgc
      121 gtgctcggcc agcgcagaag gggttgcggc agcgccaagg aaaggaagtc tcatgctccg
      181 ggaaatggcc tgatatgaag gagtcacacc tccagccttc cctgtgggtg ccttgtcctt
      241 tgggtgcagg agctggctga aacatcagga atggaagcca atgtgactat cccaatctgg
      301 cagaacaagc cacatggggc tgctcgcagt gtggtaagaa gaattgggac caatctgccc
      361 ctgaaacctt gtccacgggc atcctttgag accctgccca acatctctga cctgtgtttg
      421 aaagatgtgc ctccagtccc gactctggct gacatcgcct ggattgccgc agatgaagag
      481 gagacatatg ctcgggtcag gagcgataca cgccctctga gacatacctg gaagcccagc
      541 cctctgattg tcatgcaacg gaatgcctca gtgcccaatc tgcgtgggtc tgaggagagg
      601 ctcctggccc tgaagaagcc agccctgcct gccctaagcc gcaccactga gctgcaggat
      661 gaactaagcc acctgcgcag ccagattgct aaaatagtgg cagcagatgc agcttcggcc
      721 tcattaacgc cagatttctt atcttcagga agttcaaatg tctcctctcc tttgccttgc
      781 tttggatcct cattccactc tacaacttcc tttgtcatta gtgacatcac tgaggagact
      841 gaggttgagg tccccgagct tccaacaatc cccctgcttt gttctgccag ccctgaatgt
      901 tgcaaatcag aacacaaaac tacctgcagc tcgtctgaag aggatgactg catctctctg
      961 tccaaggcca gcagctttgc agacatgatg ggcatcctga aggattttca tcggataaaa
     1021 cagagccaag acctgagccg gagtttactg aaggaagaag accctgctgt ccttatctct
     1081 gaggtcctta ggaggaagtt tgccctgaag gaagaagaca tcagtagaaa aggaaactga
     1141 cagcactgac tgcaaactct tctcttgctc ctgaactcct tcaatagctg ccttcctcac
     1201 tgcagatgtc tgtctcagtt gagatctgaa cagtcttgct gactagggct tgggctggaa
     1261 gagaagagct ggattatttg ttacctgcac ttaaaccctg gcagagtcta aggtctatgg
     1321 tttttggaga tgtgacattt gttacaggta attgggtaga gtggagtatc tctgcttaag
     1381 gcgtgaagtt tgttttttct tgtctctgaa aaataagccc tctatgaatg acttaattaa
     1441 ctcactgcat tagactccat aattggtctc actggacatg ttgtgcacag cagtcactct
     1501 cggcagcttc cctgcagcac cacagggctg agggggagcg gctgttagtt catgctcaca
     1561 ggaaggtctt ctgctgcttc atcacagaca tacaccagtg cccacagtca ccctttccct
     1621 ctagctgcag agggcaggcc actgggccag ccaatatctg ggctgctgca gggaggcctg
     1681 gcctgttttt tcttaaacat tttataaaac tacaacctga tctaccctcc agggcctcat
     1741 tagttccact gattgaattt ttttttcttc catggactta ctaagtccat cttggaagga
     1801 gaaatgtgga gacaaaaaga gcataccatc cttctaggac agtgactgat ctctctaggt
     1861 tgggtcaaga ttttatttac tgcatcatgc atgactcagg tgccctcagg gcccttttct
     1921 ctatggtatg aatactgtgt gttttgagtt gaagcattac ctgatattaa atgaaggatt
     1981 tggagaaatg gtgtagtttt tctttattct gtctctgaat tttgaccaca gtggcctctg
     2041 gtgaagagag ggctcctgtt gattctaagg tatgtgaact tttaaaaaac aggctcctga
     2101 cttcctttct tgccctcagg acagtggtgc tcactgtgac cctttaatac aagtccttat
     2161 gctatggtga ccccctctcc ccacatccat aaaattttgt tgctacttca taactaaatt
     2221 tgctaccatt aagagttgta atatgggctg tatagacggc tcagtggttg ggagcactga
     2281 ctgttctttc cggaggttct gagttcaaat cccagcaatg acatcgtggc tcaaaaccat
     2341 ctgtaatgag atccgatgcc ctcttctggt gtgtctgaag acagctacag tgtacttaca
     2401 tataataaat aaataaatct taaaaaaaaa
//
LOCUS       NM_001436702            5962 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus ERCC excision repair 6, chromatin remodeling
            factor (Ercc6), transcript variant 3, mRNA.
ACCESSION   NM_001436702 XM_006252737
VERSION     NM_001436702.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5962)
  AUTHORS   Xu,Y., Wu,Z., Liu,L., Liu,J. and Wang,Y.
  TITLE     Rat Model of Cockayne Syndrome Neurological Disease
  JOURNAL   Cell Rep 29 (4), 800-809 (2019)
   PUBMED   31644904
  REMARK    GeneRIF: Rat Model of Cockayne Syndrome Neurological Disease.
REFERENCE   2  (bases 1 to 5962)
  AUTHORS   Yang,Z., Liu,C., Wu,H., Xie,Y., Gao,H. and Zhang,X.
  TITLE     CSB affected on the sensitivity of lung cancer cells to
            platinum-based drugs through the global decrease of let-7 and
            miR-29
  JOURNAL   BMC Cancer 19 (1), 948 (2019)
   PUBMED   31615563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5962)
  AUTHORS   West,H., Coffey,M., Wagner,M.J., McLeod,H.L., Colley,J.P.,
            Adams,R.A., Fleck,O., Maughan,T.S., Fisher,D., Kaplan,R.S.,
            Harris,R. and Cheadle,J.P.
  TITLE     Role for Nucleotide Excision Repair Gene Variants in
            Oxaliplatin-Induced Peripheral Neuropathy
  JOURNAL   JCO Precis Oncol 2, 1-18 (2018)
   PUBMED   35135151
REFERENCE   4  (bases 1 to 5962)
  AUTHORS   Luo,S.S., Liao,X.W. and Zhu,X.D.
  TITLE     Prognostic Value of Excision Repair Cross-Complementing mRNA
            Expression in Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 6204684 (2018)
   PUBMED   30417012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5962)
  AUTHORS   Pascucci,B., Fragale,A., Marabitti,V., Leuzzi,G., Calcagnile,A.S.,
            Parlanti,E., Franchitto,A., Dogliotti,E. and D'Errico,M.
  TITLE     CSA and CSB play a role in the response to DNA breaks
  JOURNAL   Oncotarget 9 (14), 11581-11591 (2018)
   PUBMED   29545921
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5962)
  AUTHORS   Dianov,G., Bischoff,C., Sunesen,M. and Bohr,V.A.
  TITLE     Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome
            group B cells
  JOURNAL   Nucleic Acids Res 27 (5), 1365-1368 (1999)
   PUBMED   9973627
REFERENCE   7  (bases 1 to 5962)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Cockayne syndrome group B protein enhances elongation by RNA
            polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11205-11209 (1997)
   PUBMED   9326587
REFERENCE   8  (bases 1 to 5962)
  AUTHORS   van der Horst,G.T., van Steeg,H., Berg,R.J., van Gool,A.J., de
            Wit,J., Weeda,G., Morreau,H., Beems,R.B., van Kreijl,C.F., de
            Gruijl,F.R., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Defective transcription-coupled repair in Cockayne syndrome B mice
            is associated with skin cancer predisposition
  JOURNAL   Cell 89 (3), 425-435 (1997)
   PUBMED   9150142
REFERENCE   9  (bases 1 to 5962)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Human transcription-repair coupling factor CSB/ERCC6 is a
            DNA-stimulated ATPase but is not a helicase and does not disrupt
            the ternary transcription complex of stalled RNA polymerase II
  JOURNAL   J Biol Chem 272 (3), 1885-1890 (1997)
   PUBMED   8999876
REFERENCE   10 (bases 1 to 5962)
  AUTHORS   Henning,K.A., Li,L., Iyer,N., McDaniel,L.D., Reagan,M.S.,
            Legerski,R., Schultz,R.A., Stefanini,M., Lehmann,A.R., Mayne,L.V.
            and Friedberg,E.C.
  TITLE     The Cockayne syndrome group A gene encodes a WD repeat protein that
            interacts with CSB protein and a subunit of RNA polymerase II TFIIH
  JOURNAL   Cell 82 (4), 555-564 (1995)
   PUBMED   7664335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252737.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000016.1  7771357-7771417
            62-493              JAXUCZ010000016.1  7775249-7775680
            494-614             JAXUCZ010000016.1  7777319-7777439
            615-726             JAXUCZ010000016.1  7779273-7779384
            727-1453            JAXUCZ010000016.1  7785040-7785766
            1454-1579           JAXUCZ010000016.1  7797795-7797920
            1580-1715           JAXUCZ010000016.1  7809471-7809606
            1716-1886           JAXUCZ010000016.1  7816868-7817038
            1887-2063           JAXUCZ010000016.1  7817456-7817632
            2064-2180           JAXUCZ010000016.1  7821768-7821884
            2181-2276           JAXUCZ010000016.1  7823617-7823712
            2277-2492           JAXUCZ010000016.1  7827032-7827247
            2493-2603           JAXUCZ010000016.1  7827603-7827713
            2604-2723           JAXUCZ010000016.1  7828737-7828856
            2724-2818           JAXUCZ010000016.1  7829217-7829311
            2819-2964           JAXUCZ010000016.1  7830767-7830912
            2965-3639           JAXUCZ010000016.1  7830992-7831666
            3640-3844           JAXUCZ010000016.1  7836688-7836892
            3845-3917           JAXUCZ010000016.1  7837600-7837672
            3918-5962           JAXUCZ010000016.1  7838451-7840495
FEATURES             Location/Qualifiers
     source          1..5962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..5962
                     /gene="Ercc6"
                     /note="ERCC excision repair 6, chromatin remodeling
                     factor"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
     exon            1..61
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            62..493
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Ercc6"
                     /note="upstream in-frame stop codon"
     CDS             72..4337
                     /gene="Ercc6"
                     /note="isoform 2 is encoded by transcript variant 3; DNA
                     excision repair protein ERCC-6; excision repair
                     cross-complementing rodent repair deficiency,
                     complementation group 6; excision repair
                     cross-complementation group 6"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6 isoform 2"
                     /protein_id="NP_001423631.1"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
                     /translation="MPHEEIPNSTQPQGQDWLPGQHVSADRDIPAGQETAGDSEAGKC
                     LSSPSCDHGPSTSAEACVLAATRWGPALLHIDRHQIPAVEPSAQALELQGLGVDVYDQ
                     AVLEEGVLQQVDSAMHEASRVAQRADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQ
                     AASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAILGGAEVHVELDHGSLEEEDA
                     EPGPSCLGSMLMPAQESAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYL
                     ADQAQLSFKRKKQAANKRTAKKAVVVSESSRGPNETKPNQRSQALSQTDKRLKKHIRK
                     LQRRALQFQGKVGLQRGKRPLEPEERPGAEGDTEGEESGSSPTDGEEEEEQEEEGVAV
                     LSSDDISYELKPLRKGQKYEKKVPVQEIDDDFFPSSEEEDEAVEGRGGGRKVSRRPDD
                     GDEDYYKQRLRRWNRLRLQDKEKLKLEDDSEESDAEFDEGFKVPGFLFKKLFKFEGLG
                     PTLIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSY
                     SYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLR
                     ELWSLFDFTFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPY
                     LLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGENQIFSGL
                     VALRKICNHPDLFSGGPKNTSALPEDGLEEEQFGYWKRSGKMIVVESLLKIWHKQGQR
                     VLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTR
                     VGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIY
                     HRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQGTETSAIFAGTGSNIQT
                     LKCHFKKRTPPVLQMDPKRKKPLVSDTSVNGATVMEEKSQGSGATGSVPSTESGPLKS
                     DRHTDGSRASSVGFGEEADAGSTLEHLSGLSGDSPAVDHTSRLSAVASTSEKQGSSYE
                     GECCQAQTGPVHLSEQTEGHFSKHKSKRKHDAAEEETTEKCPQPKQKAKNSRHHRDAK
                     FEGTRVPHLVKKRRYHQQTTEQESGAKDRSSDDYVLEKLFKKSVGVHSVVKHDAIIDG
                     SSPDYVLVEAEANRVAQDALKALRLSRQQCLGATSGVPTWTGHRGISGAPAGVKKRFG
                     QKRNSSLPVQRPSSLTERTQNMKKEGEAHTAEHFSGKEDGASSSGAPSSSSLLARMRA
                     RNHMILPERLESDGEQLAGAAAAAAPPCSTEHDALLVDMRNFIAFQAQVDGQASTQEI
                     LQAFESKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEYC"
     misc_feature    318..548
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    318..548
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    order(411..413,423..425)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    order(411..413,423..425)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    <1578..2855
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    <1578..2855
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    4116..4331
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    4116..4331
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    order(4116..4121,4128..4133,4137..4142,4149..4151,
                     4161..4166,4179..4184,4269..4271,4323..4331)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     misc_feature    order(4116..4121,4128..4133,4137..4142,4149..4151,
                     4161..4166,4179..4184,4269..4271,4323..4331)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     exon            494..614
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            615..726
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1453
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1579
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1715
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1886
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2063
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2180
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2276
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2492
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2603
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2723
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2818
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2964
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3639
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3844
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..3917
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..5962
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctacgctt tgtcgcggcc gtggcgacga agatttcgtc tgggcggccg cgtggtcctg
       61 gtttgtagag gatgccccat gaggaaatcc ccaactccac tcaacctcag ggccaagact
      121 ggttaccagg tcagcatgtc agtgctgaca gagacatacc agctgggcag gagactgctg
      181 gggactcaga ggcggggaag tgcctctcct ctccttcctg tgaccatggg ccgtccacat
      241 ctgctgaagc ttgtgtactg gcagccacaa ggtgggggcc cgccctgctg cacatcgacc
      301 ggcatcagat tcctgcggtg gagcccagtg ctcaggccct ggagctgcag ggcctgggtg
      361 tggacgtcta cgaccaggcc gtcctggagg aaggtgtgct tcagcaggtg gacagtgcaa
      421 tgcatgaggc cagccgtgtg gcccagcgtg ctgatgcgga gaaagagtat cagtcagtcc
      481 tggacgacct catgtcatgt acaacatccc tgaggcaaat caataaaatt atagagcaac
      541 ttagccctca agctgccagc aacagagaca tcaacaggaa actagattct gtgaaacgac
      601 agaagtacaa caaggaacaa cagctaaaga agataactgc aaaacagaaa cgtctccagg
      661 ccattctcgg aggagcggag gtccatgtgg aactggatca tggcagctta gaggaggaag
      721 atgcagagcc aggcccatca tgtctcggca gtatgctcat gcctgcccag gagagcgcct
      781 gggaagaact tatccgcact ggccagatga caccgttcgg taccccagcc cctcagaaac
      841 aggagaaaaa gcctagaaaa ataatgctca atgaagcatc aggctttgaa aaatatttgg
      901 cagaccaagc acaactttct tttaaaagga aaaaacaagc tgctaataaa agaacagcta
      961 aaaaagctgt ggttgtatct gagtcaagcc gaggaccaaa tgaaactaag ccaaaccaga
     1021 gaagccaagc gctctctcag acagacaagc gcctgaagaa gcacatcagg aagctccaga
     1081 ggagggcgct gcagttccag ggcaaagtgg gattgcaaag ggggaagaga cctctggagc
     1141 ctgaggagag gccaggggca gagggagaca ctgagggtga ggagtctggg tcctctccca
     1201 ctgatgggga ggaagaggaa gaacaagagg aggaaggggt agccgttctg tcttccgatg
     1261 acattagcta tgaactgaag cctcttcgga aaggacaaaa atacgagaag aaagtcccag
     1321 tgcaggagat cgacgatgac ttctttccaa gttctgagga ggaagatgaa gctgtggaag
     1381 gaagaggagg aggccgcaag gtctccaggc gcccagacga tggagatgag gattattata
     1441 aacaacgatt aaggaggtgg aataggctga ggctgcagga caaagagaag ctgaagcttg
     1501 aagacgattc tgaggagagc gatgctgagt ttgacgaagg tttcaaagtg ccgggttttc
     1561 tgttcaaaaa gctctttaag ttcgagggac tcggccccac tctcattgtc tgcccaacga
     1621 cagtgatgca tcagtgggtg aaagaattcc acacgtggtg gcctccattc agagtggcga
     1681 ttctgcacga aacaggctcc tgtgcccaca gaaaggagag gctggttcga gatattgttc
     1741 attgtcatgg agttttgata acttcgtatt cctacattcg actgatgcaa gacgacatta
     1801 gcaggcatga ctggcactac gtcatcttag acgaaggaca taaaattcga aatccaaatg
     1861 ctgcagtcac ccttgcttgc aaacagttcc ggacacccca tcggatcatc ttgtcgggct
     1921 caccgatgca gaataacctg cgagagctgt ggtcactctt cgactttacc ttcccaggaa
     1981 agctaggcac gttgcctgtg ttcatggagc agttctctgt ccccatcacc atgggggggt
     2041 actccaatgc ttccccagta caggttaaaa ctgcctataa gtgtgcgtgt gtcttgagag
     2101 acacgataaa cccgtaccta ctgcgaagaa tgaaatcaga tgtcaagatg agcctttcgc
     2161 tgccagataa aaatgaacag gtcttatttt gccgtctaac tgatgagcag cataaagtct
     2221 accagaattt catcgattcc aaagcagttt acaggattct caatggagag aatcagattt
     2281 tctctggact tgtagctctg aggaagatct gcaaccaccc tgacctcttt tctggcggtc
     2341 ccaagaacac cagtgctctt ccagaggatg gactggagga ggagcagttc ggatactgga
     2401 aacgctctgg gaaaatgatt gttgttgagt ctttgctgaa aatctggcac aagcagggtc
     2461 agcgggtgct gctgttttcc cagtcaaggc agatgctgca catactggaa gtgttcctga
     2521 gagcccacaa gtattcctat ctcaagatgg atgggaccac taccatagca tccaggcagc
     2581 cgctgattac aaaatacaat gaggacacgt ccatctttgt ctttcttctg accacacggg
     2641 tgggcggctt aggagtgaac ctgaccgggg ccaacagagt catcatctac gaccctgact
     2701 ggaatccaag caccgacaca caggcacggg agcgagcatg gaggatcggc cagaagaagc
     2761 aggtgactgt ctacaggctt ctgacggccg gcaccataga ggaaaagatc tatcaccgac
     2821 aaatcttcaa gcaatttttg acaaacagag tgctaaaaga ccctaaacaa aggcgctttt
     2881 tcaagtccaa tgatctctat gagctgttta ctctgactag tcctgatgcc tcccagggca
     2941 ctgaaacaag tgctattttt gcaggaaccg gatctaatat tcagacactg aaatgccatt
     3001 ttaaaaagag gactccgcca gtcctacaaa tggatcccaa acgcaagaag cccctggttt
     3061 ctgacacatc tgtaaatggt gccactgtga tggaagaaaa atctcagggg tcaggagcta
     3121 cgggcagtgt cccttctaca gaaagtggcc ctttgaaaag tgaccgtcac acagatggga
     3181 gcagagccag cagtgttggt tttggagaag aggcagatgc agggtccacg ctggagcatc
     3241 tctcagggct gagtggagat tctccagcag ttgaccacac atccaggctg tcagctgtgg
     3301 cgagcaccag tgagaagcag ggctcttcct atgaagggga gtgctgccag gctcagacgg
     3361 gacctgttca cctgagtgaa caaacggaag gtcatttctc taagcacaaa tcaaaaagga
     3421 aacatgatgc agcggaggaa gagaccacag agaagtgtcc acagcccaag caaaaggcca
     3481 agaactccag gcatcacaga gatgctaagt ttgagggaac tcgagtccca cacctggtga
     3541 agaagaggcg gtaccatcag caaaccactg agcaggagag cggagccaag gaccggagca
     3601 gtgatgatta tgttttggaa aagcttttca aaaaatcagt gggcgtgcac agcgtcgtga
     3661 agcatgatgc catcatagat gggtccagtc cggattatgt gctggtggag gcagaagcca
     3721 acagagtggc tcaggatgcc ttgaaagctc tgaggctctc tcgtcagcag tgcctggggg
     3781 caacatctgg tgttcccacc tggactggcc acaggggtat ttccggtgca ccagcaggag
     3841 taaagaaaag gttcggtcag aaaaggaact ccagcctccc tgtgcagcgt ccttcgtcgc
     3901 taacagagag aactcagaac atgaagaagg agggggaagc tcacaccgct gagcacttca
     3961 gtggcaaaga agatggagca tcgtcgtctg gagcccccag ttcctcctcg ctcttggcca
     4021 gaatgcgagc acgaaaccac atgattttgc cggagcgttt ggagagtgac ggcgagcagc
     4081 ttgctggggc tgcggctgcg gctgcgcctc cctgcagcac agagcacgac gcccttctgg
     4141 tggacatgag gaacttcatt gctttccagg ctcaggtgga tggccaggcc agcactcagg
     4201 aaatcctaca ggcgttcgaa tccaagctgt ctgtggcaca gtcctgtgtc ttccgagaac
     4261 tactgaggaa tctgtgcaat ttccatagaa ctcctggtgg tgaagggatt tggaaactga
     4321 agccagagta ctgctaacag tgctgcttcc tgaacttttt caaataggaa tcttggctcg
     4381 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taagtgtata
     4441 agagtatagc tgcacttggt gtttactgtg tcatctacct caagactaaa acttgaagaa
     4501 gaaaataatt ggagggtttt tgtttggttt ggttttcttt tggtggcact atgaattgtt
     4561 ataaaaccag ggacctagca gttgtttaat ggagcaaata cattacttaa cccaagagat
     4621 gctgtcaggg agcacattct gtctaagagt agatcttgat tcttcttatt ggtgctggga
     4681 acgtgtcttc tctttatcca cgccatccca taggggactt cacggtatct gataacctta
     4741 gtaccttgat acagtaagta tttatgaccc actggccaca tacagaaaga tccttgctat
     4801 ctgtcaaatc attccctacg attaattctt cacagtactt ttaaagtagc aggtttgggt
     4861 tttactgttg gtctgtttta aatgttgcta acgacagtct ggtgccttgc acgtgctaag
     4921 cgagctaagc gagcatgtgc ttcaccacca ggttccatcc agttcataca tacgcatcaa
     4981 cgaaggacgt ctggcttttc ttctctgtca tcattgtgta aggaaggggg aggggtttgt
     5041 ttaaataggt cagtaacgtc tggacttcag cacttggctc agaaggcagt cacacatttt
     5101 ttcttctagt tgtcagccta caggggaatg gcgttgttct tgtcccaggc tgactcctga
     5161 tctgactcac tggtgtgagc ttttgtgctg tgtctgtaat gcctgagatc tacgtcagac
     5221 tgagctggag aaggtataaa cacctcttag atggcaagtg acctcccatg agtaagggag
     5281 gagtccatgg tccagctctg ccactgacct gcccagcctg gggaggttga ctctgtaaac
     5341 acggttttcc agccaagctg ggaaactcag agaccagtgc tctaggttaa agtacttttt
     5401 aacaatgaac aataccttta tacattaagc tgcaatctga ttttttgaac atgaaatact
     5461 ttgtgtggtg taaatagaat taatgtgtta aacatgttaa ataattgtaa ataaaagact
     5521 ttaaaattcc agcttttact gtattgtcac tgttaaagcc ttcaagcgct cctgccttcc
     5581 caccctgtgc cgatggagct gcggttccgg agccctgtgc agttgcccag gcatttgcat
     5641 ggctgctggc gtgggctgct gcttcgcttc tgtgtgtccc ctgggccagt cactgctcag
     5701 ctgacaatcg tttctcagcc tccctgcagc gaagtgtggc cgcatgacag ttccaggcag
     5761 tgagatggaa aacgccaact tgaagcttac acaaagtcat ggcatgcacg cccctgaaag
     5821 ttccctgttt tgctggtcgg gatgtgtatg aaagcctcgg gtttccgggt atttcaagag
     5881 agggtggttg gtctgccagt caagaacagc tgtccgtgac cagatacttt ggagtgaaat
     5941 aaatgaatct tatttaacac tg
//
LOCUS       NM_001436694            1417 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 10, mRNA.
ACCESSION   NM_001436694
VERSION     NM_001436694.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1290851.1,
                                           SRR26360181.1259564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-550             JAXUCZ010000016.1  7308347-7308453
            551-692             JAXUCZ010000016.1  7309595-7309736
            693-1417            JAXUCZ010000016.1  7311042-7311766
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1417
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..731
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 6 is encoded by transcript variant 10;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 6"
                     /protein_id="NP_001423623.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKVAENSCLCGNFV"
     misc_feature    468..>689
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    468..>689
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cl06868"
                     /db_xref="CDD:447143"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..692
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1417
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gaggtcatgg ctgcagctaa ggtgtgtgag atcactcacg
      481 agtctccatc agtgaagagc ctccgtttgc ttgttgctga taaagacttt tccttcaagg
      541 ctggccagtg ggttgatttc ttcatcccag gagtttcagt ggttggtggg ttttcaattt
      601 gctccagtcc ccaacagcta gaacgagaga gaataataga attggcagtg aaatacacga
      661 accatcctcc tgctgtctgg gttcacaata aggttgcaga gaattcttgc ttgtgtggga
      721 acttcgtgta aggagaggaa ggaagccaac aggagcagat gttaccggag cagcaggaca
      781 gatgcgtgct gggggacgtg gagcatcgtt cagcagagca gctgggagag caggttgagt
      841 gtactggctg cagttcagct tagtgaggag aagagctacc cagagaatca gaaacaagcc
      901 atatttgtag caagtaacat gcccttgttt tgggcactga aacttgcaaa ctaggtcact
      961 ctcttgatcc atcctccagt aagaatcatc aaaaaaaaaa aaaaagttgt aaaattataa
     1021 aagttctttt accctgaact agctctggca ccgcagcgcc ccaagatatc tgattctcca
     1081 tctcagtcag cagagactct cacctgtttg ctccatctcg tatcacacgc cgatggcttc
     1141 tctctgagcc cggcaacaat ctctccaccc atctagttca ccctttttgt ctaattaaaa
     1201 aaaacttttc tctcagatat aagctgagca caactattat cattttgtaa ttaaaagaat
     1261 aaaatatatc taacacctag tccaacattt tatcagttaa gcagaacatt tagttatcca
     1321 ttccagctta aggaaggctt aaaatctgta ttatatcttg gctagcttgt atactatctg
     1381 ataagtatcc aataaaatat gtattttcag agttaaa
//
LOCUS       NM_001436706            3175 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 3, mRNA.
ACCESSION   NM_001436706 XM_006238798
VERSION     NM_001436706.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3175)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3175)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3175)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3175)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3175)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3175)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238798.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1490392.1,
                                           SRR26360181.1768040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2337           JAXUCZ010000005.1  140860181-140860300
            2338-2424           JAXUCZ010000005.1  140860729-140860815
            2425-2552           JAXUCZ010000005.1  140860911-140861038
            2553-2646           JAXUCZ010000005.1  140862618-140862711
            2647-2777           JAXUCZ010000005.1  140862797-140862927
            2778-2874           JAXUCZ010000005.1  140863198-140863294
            2875-3175           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3175
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2867
                     /gene="Pabpc4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 3"
                     /protein_id="NP_001423635.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGNAPASRGLPTTAQRVGSECPDRLAMDFGGAGAAQQGLTD
                     SCQSGGVPTAVPNLAPRATVAAAAPRAVAPYKYASNVRSPHPAIQPLQAPQPAVHVQG
                     QEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLES
                     PESLRSKVDEAVAVLQAHHAKKEAAQKVGTVAAATS"
     misc_feature    915..2804
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2804
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2337
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2424
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2552
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2646
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2777
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2874
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3175
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg taatgctccg gcctctcgtg gccttcctac taccgctcag agagtcgggt
     2341 ctgagtgccc ggaccgcttg gctatggact ttggtggggc tggtgccgcc cagcaagggc
     2401 tgactgacag ctgccagtct ggaggcgtcc ctacggctgt gccaaacctt gcacctcgtg
     2461 ctacagtcgc tgctgctgct cccagggctg tggctccata caagtatgcc tccaatgtcc
     2521 gcagccctca ccctgccatt cagccgctgc aggcccccca gcctgcagtc catgtccagg
     2581 gtcaagaacc cctgactgcc tccatgctgg ctgcagctcc tccccaggag cagaagcaga
     2641 tgctggggga gcgtttgttc ccacttatcc aaacaatgca ttcaaacctg gctggaaaaa
     2701 ttacagggat gctgctagaa atcgacaact ctgagctgct ccacatgctg gagtcccccg
     2761 agtccctccg ttccaaggtg gatgaagctg tggcagtcct gcaggctcat catgccaaga
     2821 aagaagctgc ccagaaggtg ggcactgttg ctgctgctac ctcttaaacc agaagagtca
     2881 aaagccaaat aacccctcac ggcattcagc tgaggtctga agacttccta gtttgtctgt
     2941 ggacctcttt caagaaccaa gttacaaatt caacaggtca ttttgtatca aaaggtcaat
     3001 tatgaagcac ctagaatttt tcaattataa gaatatattc tctgggttct gttgtggccc
     3061 agatgatggt aacttttttt tctattatga gttctgtttt ttttcccctc tcccagaaat
     3121 tggttttgat gtacccaaga cttaagtttc tcaataaagg aaataaaatc tccaa
//
LOCUS       NM_001436676            3331 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 6, mRNA.
ACCESSION   NM_001436676
VERSION     NM_001436676.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3331)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3331)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3331)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3331)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3331)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3331)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3331)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3331)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3331)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3331)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.55582.1,
                                           SRR26643298.70514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN13663631
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000016.1  6453307-6453399
            94-148              JAXUCZ010000016.1  6453812-6453866
            149-281             JAXUCZ010000016.1  6454871-6455003
            282-401             JAXUCZ010000016.1  6455366-6455485
            402-463             JAXUCZ010000016.1  6455976-6456037
            464-606             JAXUCZ010000016.1  6456213-6456355
            607-685             JAXUCZ010000016.1  6456604-6456682
            686-809             JAXUCZ010000016.1  6457065-6457188
            810-957             JAXUCZ010000016.1  6457443-6457590
            958-1142            JAXUCZ010000016.1  6458022-6458206
            1143-1270           JAXUCZ010000016.1  6458575-6458702
            1271-1749           JAXUCZ010000016.1  6459242-6459720
            1750-1910           JAXUCZ010000016.1  6459835-6459995
            1911-2003           JAXUCZ010000016.1  6460240-6460332
            2004-2076           JAXUCZ010000016.1  6460433-6460505
            2077-3331           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3331
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..93
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     exon            94..148
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..281
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2210
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 6;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 3"
                     /protein_id="NP_001423605.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFS
                     PESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF
                     ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRV
                     KYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLE
                     AGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQ
                     RLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSA
                     IRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGS
                     PAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVL
                     FGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSS
                     QGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYE
                     ACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS
                     IGRLHKQRKPDRRKRSRPYKAKRQ"
     misc_feature    <264..725
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    <264..725
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    order(279..281,297..299,531..533,576..578)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(279..281,297..299,531..533,576..578)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(279..281,297..299,531..533,576..578)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(279..281,297..299,531..533,576..578)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    1947..2084
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    1947..2084
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     exon            282..401
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..463
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..606
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..685
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..809
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..957
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1142
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1270
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1749
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1910
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2003
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2076
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..3331
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctgcgc gcgcgcatcc ggcctccgcg caggcggaag gccagccccg gattaggctc
       61 gtcgtgtgtg atgacgttgt actcccggcg cgggtgtcaa aggggtgcaa gtggaggaga
      121 tctatgacct tcagagtaaa tgccaggggc ctgtatatgg atttatcttc ctgttcaaat
      181 ggatcgaaga gcgcaggtcc cgccgcaagg tttctacgtt ggtggatgat acatctgtga
      241 ttgatgatga catcgtgaat agcatgttct ttgctcacca gctgattccc aactcttgtg
      301 ccactcacgc cttgctgagc gtgcttctga actgcagcaa tgtggatttg gggcccacgc
      361 tgagtcgaat gaaggatttc accaaaggct tcagccctga gagcaaagga tatgcgattg
      421 gcaatgcccc tgaactggcc aaggcacata atagccatgc caggccagaa ccacgtcacc
      481 ttcctgagaa acagaatggc ctcagtgcag tgcggaccat ggaggcgttt cactttgtca
      541 gctatgtgcc tatcacagga cggctctttg aattggatgg gttgaaagtc taccctattg
      601 atcatgggcc ctggggagag gatgaggagt ggacagataa agcccgaagg gtcatcatgg
      661 agcgaatcgg ccttgctact gcaggggagc cctaccatga cattcgcttc aacctgatgg
      721 cagtggtgcc tgaccgcagg gttaagtatg aggccaggct gcatgtgctg aaggggaacc
      781 gacaaacagt cctggaggcc ctgcagcagc tgattagagt aacacagcca gagctgattc
      841 agacccacaa atctcaagag tcacaactgc ctgaggagag caagccagcc agcagcaagt
      901 ctccctttgg gctagaggcg ggcagaaccc cggcggcctc tgagtgcact cacacagatg
      961 gtgcagagga ggtggctggt tcgtgcccac aaactacaac ccatagtcct cccagcaaat
     1021 ctaagctggt ggtgaagcct tcagggagca gcctcaatgg ggttccccca acccctaccc
     1081 ctattgtcca gcggctgcca gcctttctag ataatcacaa ttatgccaaa tcccctatgc
     1141 aggaggagga agacctggcg gcaggtgtgg gccgcagccg agttccagtc cgaccccagc
     1201 agtactctga tgatgaggag gactatgagg atgaggagga ggatgtgcag aataccagtt
     1261 ctgccatcag atacaagcgg aaggggacag ggaagccagg atcgttgagc aattcttcag
     1321 atgggcagct gtcagtgctg cagcccaaca ccatcaatgt cttaactgag aagcttcaag
     1381 agtctcagaa agacctttca attcctctgt ccatcaagac tagcagtggg gctgggagtc
     1441 cagccgtggc tgtgcccaca cactcgcagc cttcacccac ccctagcaat gagagcacgg
     1501 acacagcctc tgagattggc agtgctttca actcaccctt gcgctcaccc atccgctcag
     1561 ccaacccaac acggccctct agccctgtca cctctcacat ctccaaggtg ctctttggag
     1621 aagatgacag cctacttcgt gttgactgca tacgctacaa ccgtgctgtc cgtgacctgg
     1681 gtcctgtcat tagcacgggc ctgctgcacc ttgctgagga tggtgtactg agtcccctgg
     1741 cactcacaga gggtgggaag ggttcctcac cttctaccag atcaagccaa ggcagccagg
     1801 ggtccagcag cctagaggag aaggaggtgg tggaagtcac agatagcaga gacaagtctg
     1861 ggctgaacag gtccagtgag cccttgagtg gagagaagta ctcgcccaag gagctgttag
     1921 cactgttaaa gtgtgtagag gccgagattg caaactatga ggcctgtctc aaggaggagg
     1981 tggagaaaag gaagaagttc aagattgatg accagcgaag gacccacaac tatgatgagt
     2041 tcatctgcac cttcatatcc atgctggctc aggaaggaat gctggccaac ctggtggagc
     2101 agaacatctc agtgcggcgc cgccaagggg tcagcattgg tcggcttcac aagcagcgga
     2161 agcctgatag gcggaaacgc tctcgcccct acaaggccaa acgccagtga ggacctctag
     2221 ccctgactct gcagcctctc ttgccgcaag gccctcacca gggcccttca ctgttcgact
     2281 tttccaagta ttactgaata gttcagctag agctcaggcc ctgggagtag gaatgggatg
     2341 tgtattctgc attatgctct ggggtctggc agggacaagg cagctccata atgctcagga
     2401 agcagcagct ggaattggag ggtgctgtgg cctccacggc catctgagga gcagcaggat
     2461 atatattcta cctgttggag atgtctattt ttttgacttt tggccatctt gccactgtat
     2521 taacatggcc agcttcctga ctctgctttc tctcccagca gctgtcattc tgctgggccc
     2581 aggtctctta taaccacagt accagctggg aaacccagaa ggcattggtc ctggtgctct
     2641 agcaccagcc accagcctgt ccttgttgtg aagaagcttg gcctactact cttgattcct
     2701 tctgggagag cgccaaactc agggacctgg ctgctgagct ggaatgggca tggggtatcc
     2761 tagtaggatg tacagcctat cagggtccca cagctatcgt ggagacaagt gtttgaactg
     2821 tcctcgtacc acccagactt gttagtgagt cagagcaggg ctctggggct ctttgccttc
     2881 agtgttgtgg ccctggccgt gggcctacct taggctccta atctccgtct ctggggtcca
     2941 gaggagccac tacttagccc ctcagtatta ccatgtctcc tcttaggaat gtcagaggca
     3001 gggctgctcg aatgaggctg gcactattca attctcccga ccgtgccagc ttccttggcc
     3061 tcatgcaggt actcagggta ggggacaggg tcaagaggag ttagaacttc tgtgttccca
     3121 tagggcttga tgccagtggg gtagtaagca cagcactgct tcaagctcca ggcccagata
     3181 gccctgtgcc ctctgctaga tacaggtgat ccaagcaggc cccttacctg tacatagcaa
     3241 ctgtcggggg gatggtacag cagtccgacc cgctatagtg tctgtaaata ctgaatcagt
     3301 gagtgaagaa taaaagtgtg ctaataagtg a
//
LOCUS       NM_001436707            3138 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 4, mRNA.
ACCESSION   NM_001436707 XM_006238799
VERSION     NM_001436707.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3138)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3138)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3138)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3138)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3138)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238799.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7639.1,
                                           SRR26643298.28796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2337           JAXUCZ010000005.1  140860181-140860300
            2338-2424           JAXUCZ010000005.1  140860729-140860815
            2425-2552           JAXUCZ010000005.1  140860911-140861038
            2553-2646           JAXUCZ010000005.1  140862618-140862711
            2647-2777           JAXUCZ010000005.1  140862797-140862927
            2778-2837           JAXUCZ010000005.1  140863198-140863257
            2838-3138           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3138
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2855
                     /gene="Pabpc4"
                     /note="isoform 4 is encoded by transcript variant 4;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 4"
                     /protein_id="NP_001423636.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGNAPASRGLPTTAQRVGSECPDRLAMDFGGAGAAQQGLTD
                     SCQSGGVPTAVPNLAPRATVAAAAPRAVAPYKYASNVRSPHPAIQPLQAPQPAVHVQG
                     QEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLES
                     PESLRSKVDEAVAVLQAHHAKKEAAQKESKAK"
     misc_feature    915..2804
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2804
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2337
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2424
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2552
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2646
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2777
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2837
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3138
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg taatgctccg gcctctcgtg gccttcctac taccgctcag agagtcgggt
     2341 ctgagtgccc ggaccgcttg gctatggact ttggtggggc tggtgccgcc cagcaagggc
     2401 tgactgacag ctgccagtct ggaggcgtcc ctacggctgt gccaaacctt gcacctcgtg
     2461 ctacagtcgc tgctgctgct cccagggctg tggctccata caagtatgcc tccaatgtcc
     2521 gcagccctca ccctgccatt cagccgctgc aggcccccca gcctgcagtc catgtccagg
     2581 gtcaagaacc cctgactgcc tccatgctgg ctgcagctcc tccccaggag cagaagcaga
     2641 tgctggggga gcgtttgttc ccacttatcc aaacaatgca ttcaaacctg gctggaaaaa
     2701 ttacagggat gctgctagaa atcgacaact ctgagctgct ccacatgctg gagtcccccg
     2761 agtccctccg ttccaaggtg gatgaagctg tggcagtcct gcaggctcat catgccaaga
     2821 aagaagctgc ccagaaggag tcaaaagcca aataacccct cacggcattc agctgaggtc
     2881 tgaagacttc ctagtttgtc tgtggacctc tttcaagaac caagttacaa attcaacagg
     2941 tcattttgta tcaaaaggtc aattatgaag cacctagaat ttttcaatta taagaatata
     3001 ttctctgggt tctgttgtgg cccagatgat ggtaactttt ttttctatta tgagttctgt
     3061 tttttttccc ctctcccaga aattggtttt gatgtaccca agacttaagt ttctcaataa
     3121 aggaaataaa atctccaa
//
LOCUS       NM_001436687            1969 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 3, mRNA.
ACCESSION   NM_001436687 XM_006252626
VERSION     NM_001436687.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252626.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.41040.1,
                                           SRR26643429.49847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-365             JAXUCZ010000016.1  7305064-7305184
            366-429             JAXUCZ010000016.1  7305489-7305552
            430-536             JAXUCZ010000016.1  7308347-7308453
            537-678             JAXUCZ010000016.1  7309595-7309736
            679-921             JAXUCZ010000016.1  7324014-7324256
            922-1030            JAXUCZ010000016.1  7326003-7326111
            1031-1969           JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1969
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    211..213
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..365
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1185
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 1 is encoded by transcript variant 3;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001423616.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFD
                     PQPTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTS
                     ELLFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAET
                     LFYVCGPPPMTDFFSKHLESSHVPKEHICFEKWW"
     misc_feature    454..1173
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    454..1173
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(535..537,571..582,631..639,649..660,781..783)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(535..537,571..582,631..639,649..660,781..783)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(571..573,577..582)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(571..573,577..582)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(649..651,658..660,667..669,688..690)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(649..651,658..660,667..669,688..690)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(766..768,778..789,793..795)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(766..768,778..789,793..795)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(781..786,889..897,1096..1101)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(781..786,889..897,1096..1101)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     exon            366..429
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            430..536
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            537..678
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            679..921
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1030
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1969
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcaggcagca ccatggccca tgtcttgatt cctgggttgt ctcgaggctc tgtgggagcc
      301 atctgcactc aggctgcttc gtgggcactg cctaccagca ctctgcgttc ccttacctta
      361 gccagcgtaa tgagatccag aaggaaaact gaccacctag agagaaccgc cactgtcctc
      421 cgccgggagg tcatggctgc agctaaggtg tgtgagatca ctcacgagtc tccatcagtg
      481 aagagcctcc gtttgcttgt tgctgataaa gacttttcct tcaaggctgg ccagtgggtt
      541 gatttcttca tcccaggagt ttcagtggtt ggtgggtttt caatttgctc cagtccccaa
      601 cagctagaac gagagagaat aatagaattg gcagtgaaat acacgaacca tcctcctgct
      661 gtctgggttc acaataagtg cacacttgac tcagaagtgg ctctcagagt aggtggagag
      721 ttcttctttg accctcagcc cacagatgcc cctcgaaacc tcgtcttgat tgctggaggg
      781 gttgggatta accccctgct ttctatcctg cgccactcgg cagatctcca ccgggaccac
      841 aaagaaaaaa ggagaggcta tgatatagga acaataaaac tgttctacag cgcaaagaac
      901 accagtgaac tcctgtttaa gaaaaatatc ctcgacttag tacatgagtt tcctgagaag
      961 attgcctgca gttttcacgt tacaaaacag acgacccaaa tcagttctga acttaagcct
     1021 tatgtcacag atggaagaat aacagagaag gagataagag agcacatttc ggcagagact
     1081 ctgttctatg tctgcggccc acctccaatg acagactttt tctctaagca tctggaaagc
     1141 agccacgttc ccaaggaaca catctgcttt gagaagtggt ggtaggagca ggcacagaag
     1201 acctgagagc cgctcaggac agtgagaacc agcaacagag tcacacgaga aacttcccgc
     1261 agacttcatt ggtggcacta tttttcacta tattgatttt tctttcatta attatcctat
     1321 gatagttcat tattacagaa tttctgacct ttggggaaaa gaccatgctc aacccaattg
     1381 taattaaaag atttactgat gagctgctgg caggaagaca ggctgagagc cagatttgag
     1441 atggccataa ataaaagagg gtggggggaa aggtttccca aagggaaaac catggggagg
     1501 ctcacggtat ctatgcaagc aggcagactc tggcctgttc tgccaagatt aagtgggtaa
     1561 agcaactgga aacaatctgg gtgtctgcac acgcaagtta cagaagctga aaacggcctc
     1621 catagccagg agaagctcac agctgtgcgt ttctggggac ccctgagcca gggctgtttt
     1681 ctgggacccc gtctttctgg aattttgagt ctatggcgag cagtcatcag tactaagatg
     1741 gagggaggcc tagaaaaaaa tagtttctcg agttggcctt tacaccacga actgattaat
     1801 acaggttttt cttttgccct ttgggggcaa attagtctaa ttatgttaat taaaggaaag
     1861 tgtgggtttt gtgtgaactg tatacttctc taaataattg gacagaaatt cataaaattt
     1921 atgtttactg aatttataat tttaaataca ttctttattt tgaaatgtc
//
LOCUS       NM_001436662             917 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 4, mRNA.
ACCESSION   NM_001436662 XM_039094505
VERSION     NM_001436662.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 917)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 917)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 917)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_039094505.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74643.1,
                                           SRR26360181.1684153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000016.1  43955989-43956211   c
            224-342             JAXUCZ010000016.1  43954509-43954627   c
            343-563             JAXUCZ010000016.1  43954179-43954399   c
            564-680             JAXUCZ010000016.1  43950649-43950765   c
            681-917             JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..917
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..223
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="upstream in-frame stop codon"
     CDS             119..829
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 4"
                     /protein_id="NP_001423591.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MSGVSTSPEELPPVSFRPALAAGPGSQLLPEECYQFLAKKKFKL
                     PKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQDDFANFTDYSYQMRLPLVPRST
                     VSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQMLQRKLSRKLNPGWFDIKPTVGEI
                     TVGHLPAHSYKHKYKSKVSKERAVSSLSKSGNDVQPHREIHVKQNGKPCDATAKPMIN
                     VEETMKDTEEVALKKSCH"
     exon            224..342
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..563
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..680
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..917
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac cagtttctag cgaaaaaaaa
      241 atttaaacta cctaaagaac tcatccatgg aacaattcac tgtaaggctg gggtgcctga
      301 aatactgatt caggagattt acactttact cacccatcaa gaaattagaa gcatccagga
      361 tgattttgct aatttcacag actatagtta tcagatgcgt ttgcccctgg ttcccaggag
      421 tacagtatca aagtctatta aaaataacat taggttatcg gaactactaa gcaatcctaa
      481 tattctcagc aatgaactca agatagaatt cctcttcctt ttgcaaatgc tgcaaagaaa
      541 attaagcaga aaattgaatc cagggtggtt tgatatcaaa ccaacagtgg gagaaatcac
      601 agttggccat cttcctgccc atagctataa gcacaaatac aaatcaaaag tttcaaagga
      661 aagagctgtg tcgtctttat caaaatcagg caatgatgtc caaccacata gagaaatcca
      721 tgtgaagcaa aatggaaaac cttgtgatgc cactgcaaaa cctatgataa atgtggaaga
      781 aacaatgaaa gacacggagg aagtagcttt gaagaagtca tgtcattaat gtctaccaca
      841 atctgggtat ataatgacac acccagtctt ggatgtattt aaataataaa taacttaact
      901 tggtgtctta accataa
//
LOCUS       NM_001436686            2076 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 2, mRNA.
ACCESSION   NM_001436686 XM_006252625
VERSION     NM_001436686.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252625.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32232.1,
                                           SRR26643295.52009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-351             JAXUCZ010000016.1  7303950-7304056
            352-472             JAXUCZ010000016.1  7305064-7305184
            473-536             JAXUCZ010000016.1  7305489-7305552
            537-643             JAXUCZ010000016.1  7308347-7308453
            644-785             JAXUCZ010000016.1  7309595-7309736
            786-1028            JAXUCZ010000016.1  7324014-7324256
            1029-1137           JAXUCZ010000016.1  7326003-7326111
            1138-2076           JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2076
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            245..351
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    348..350
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            352..472
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1292
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 1 is encoded by transcript variant 2;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001423615.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFD
                     PQPTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTS
                     ELLFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAET
                     LFYVCGPPPMTDFFSKHLESSHVPKEHICFEKWW"
     misc_feature    561..1280
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    561..1280
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(642..644,678..689,738..746,756..767,888..890)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(642..644,678..689,738..746,756..767,888..890)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(678..680,684..689)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(678..680,684..689)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(756..758,765..767,774..776,795..797)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(756..758,765..767,774..776,795..797)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(873..875,885..896,900..902)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(873..875,885..896,900..902)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(888..893,996..1004,1203..1208)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(888..893,996..1004,1203..1208)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     exon            473..536
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            537..643
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            644..785
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1028
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1137
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..2076
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcaggaactt tgtgggaact tctctgtgtt ctggctggtg cgaatctaga ggtctcagta
      301 cagcactgtg tcagccagct gaggactccc agaaccttat gggtttctaa agcagcacca
      361 tggcccatgt cttgattcct gggttgtctc gaggctctgt gggagccatc tgcactcagg
      421 ctgcttcgtg ggcactgcct accagcactc tgcgttccct taccttagcc agcgtaatga
      481 gatccagaag gaaaactgac cacctagaga gaaccgccac tgtcctccgc cgggaggtca
      541 tggctgcagc taaggtgtgt gagatcactc acgagtctcc atcagtgaag agcctccgtt
      601 tgcttgttgc tgataaagac ttttccttca aggctggcca gtgggttgat ttcttcatcc
      661 caggagtttc agtggttggt gggttttcaa tttgctccag tccccaacag ctagaacgag
      721 agagaataat agaattggca gtgaaataca cgaaccatcc tcctgctgtc tgggttcaca
      781 ataagtgcac acttgactca gaagtggctc tcagagtagg tggagagttc ttctttgacc
      841 ctcagcccac agatgcccct cgaaacctcg tcttgattgc tggaggggtt gggattaacc
      901 ccctgctttc tatcctgcgc cactcggcag atctccaccg ggaccacaaa gaaaaaagga
      961 gaggctatga tataggaaca ataaaactgt tctacagcgc aaagaacacc agtgaactcc
     1021 tgtttaagaa aaatatcctc gacttagtac atgagtttcc tgagaagatt gcctgcagtt
     1081 ttcacgttac aaaacagacg acccaaatca gttctgaact taagccttat gtcacagatg
     1141 gaagaataac agagaaggag ataagagagc acatttcggc agagactctg ttctatgtct
     1201 gcggcccacc tccaatgaca gactttttct ctaagcatct ggaaagcagc cacgttccca
     1261 aggaacacat ctgctttgag aagtggtggt aggagcaggc acagaagacc tgagagccgc
     1321 tcaggacagt gagaaccagc aacagagtca cacgagaaac ttcccgcaga cttcattggt
     1381 ggcactattt ttcactatat tgatttttct ttcattaatt atcctatgat agttcattat
     1441 tacagaattt ctgacctttg gggaaaagac catgctcaac ccaattgtaa ttaaaagatt
     1501 tactgatgag ctgctggcag gaagacaggc tgagagccag atttgagatg gccataaata
     1561 aaagagggtg gggggaaagg tttcccaaag ggaaaaccat ggggaggctc acggtatcta
     1621 tgcaagcagg cagactctgg cctgttctgc caagattaag tgggtaaagc aactggaaac
     1681 aatctgggtg tctgcacacg caagttacag aagctgaaaa cggcctccat agccaggaga
     1741 agctcacagc tgtgcgtttc tggggacccc tgagccaggg ctgttttctg ggaccccgtc
     1801 tttctggaat tttgagtcta tggcgagcag tcatcagtac taagatggag ggaggcctag
     1861 aaaaaaatag tttctcgagt tggcctttac accacgaact gattaataca ggtttttctt
     1921 ttgccctttg ggggcaaatt agtctaatta tgttaattaa aggaaagtgt gggttttgtg
     1981 tgaactgtat acttctctaa ataattggac agaaattcat aaaatttatg tttactgaat
     2041 ttataatttt aaatacattc tttattttga aatgtc
//
LOCUS       NM_001436701            6137 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus ERCC excision repair 6, chromatin remodeling
            factor (Ercc6), transcript variant 2, mRNA.
ACCESSION   NM_001436701 XM_006252736
VERSION     NM_001436701.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6137)
  AUTHORS   Xu,Y., Wu,Z., Liu,L., Liu,J. and Wang,Y.
  TITLE     Rat Model of Cockayne Syndrome Neurological Disease
  JOURNAL   Cell Rep 29 (4), 800-809 (2019)
   PUBMED   31644904
  REMARK    GeneRIF: Rat Model of Cockayne Syndrome Neurological Disease.
REFERENCE   2  (bases 1 to 6137)
  AUTHORS   Yang,Z., Liu,C., Wu,H., Xie,Y., Gao,H. and Zhang,X.
  TITLE     CSB affected on the sensitivity of lung cancer cells to
            platinum-based drugs through the global decrease of let-7 and
            miR-29
  JOURNAL   BMC Cancer 19 (1), 948 (2019)
   PUBMED   31615563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6137)
  AUTHORS   West,H., Coffey,M., Wagner,M.J., McLeod,H.L., Colley,J.P.,
            Adams,R.A., Fleck,O., Maughan,T.S., Fisher,D., Kaplan,R.S.,
            Harris,R. and Cheadle,J.P.
  TITLE     Role for Nucleotide Excision Repair Gene Variants in
            Oxaliplatin-Induced Peripheral Neuropathy
  JOURNAL   JCO Precis Oncol 2, 1-18 (2018)
   PUBMED   35135151
REFERENCE   4  (bases 1 to 6137)
  AUTHORS   Luo,S.S., Liao,X.W. and Zhu,X.D.
  TITLE     Prognostic Value of Excision Repair Cross-Complementing mRNA
            Expression in Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 6204684 (2018)
   PUBMED   30417012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6137)
  AUTHORS   Pascucci,B., Fragale,A., Marabitti,V., Leuzzi,G., Calcagnile,A.S.,
            Parlanti,E., Franchitto,A., Dogliotti,E. and D'Errico,M.
  TITLE     CSA and CSB play a role in the response to DNA breaks
  JOURNAL   Oncotarget 9 (14), 11581-11591 (2018)
   PUBMED   29545921
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6137)
  AUTHORS   Dianov,G., Bischoff,C., Sunesen,M. and Bohr,V.A.
  TITLE     Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome
            group B cells
  JOURNAL   Nucleic Acids Res 27 (5), 1365-1368 (1999)
   PUBMED   9973627
REFERENCE   7  (bases 1 to 6137)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Cockayne syndrome group B protein enhances elongation by RNA
            polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11205-11209 (1997)
   PUBMED   9326587
REFERENCE   8  (bases 1 to 6137)
  AUTHORS   van der Horst,G.T., van Steeg,H., Berg,R.J., van Gool,A.J., de
            Wit,J., Weeda,G., Morreau,H., Beems,R.B., van Kreijl,C.F., de
            Gruijl,F.R., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Defective transcription-coupled repair in Cockayne syndrome B mice
            is associated with skin cancer predisposition
  JOURNAL   Cell 89 (3), 425-435 (1997)
   PUBMED   9150142
REFERENCE   9  (bases 1 to 6137)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Human transcription-repair coupling factor CSB/ERCC6 is a
            DNA-stimulated ATPase but is not a helicase and does not disrupt
            the ternary transcription complex of stalled RNA polymerase II
  JOURNAL   J Biol Chem 272 (3), 1885-1890 (1997)
   PUBMED   8999876
REFERENCE   10 (bases 1 to 6137)
  AUTHORS   Henning,K.A., Li,L., Iyer,N., McDaniel,L.D., Reagan,M.S.,
            Legerski,R., Schultz,R.A., Stefanini,M., Lehmann,A.R., Mayne,L.V.
            and Friedberg,E.C.
  TITLE     The Cockayne syndrome group A gene encodes a WD repeat protein that
            interacts with CSB protein and a subunit of RNA polymerase II TFIIH
  JOURNAL   Cell 82 (4), 555-564 (1995)
   PUBMED   7664335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252736.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.70603.1,
                                           SRR26360186.2898797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000016.1  7771606-7771682
            78-509              JAXUCZ010000016.1  7775249-7775680
            510-630             JAXUCZ010000016.1  7777319-7777439
            631-742             JAXUCZ010000016.1  7779273-7779384
            743-1469            JAXUCZ010000016.1  7785040-7785766
            1470-1595           JAXUCZ010000016.1  7797795-7797920
            1596-1754           JAXUCZ010000016.1  7803448-7803606
            1755-1890           JAXUCZ010000016.1  7809471-7809606
            1891-2061           JAXUCZ010000016.1  7816868-7817038
            2062-2238           JAXUCZ010000016.1  7817456-7817632
            2239-2355           JAXUCZ010000016.1  7821768-7821884
            2356-2451           JAXUCZ010000016.1  7823617-7823712
            2452-2667           JAXUCZ010000016.1  7827032-7827247
            2668-2778           JAXUCZ010000016.1  7827603-7827713
            2779-2898           JAXUCZ010000016.1  7828737-7828856
            2899-2993           JAXUCZ010000016.1  7829217-7829311
            2994-3139           JAXUCZ010000016.1  7830767-7830912
            3140-3814           JAXUCZ010000016.1  7830992-7831666
            3815-4019           JAXUCZ010000016.1  7836688-7836892
            4020-4092           JAXUCZ010000016.1  7837600-7837672
            4093-6137           JAXUCZ010000016.1  7838451-7840495
FEATURES             Location/Qualifiers
     source          1..6137
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..6137
                     /gene="Ercc6"
                     /note="ERCC excision repair 6, chromatin remodeling
                     factor"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
     exon            1..77
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            78..509
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    82..84
                     /gene="Ercc6"
                     /note="upstream in-frame stop codon"
     CDS             88..4512
                     /gene="Ercc6"
                     /note="isoform 1 is encoded by transcript variant 2; DNA
                     excision repair protein ERCC-6; excision repair
                     cross-complementing rodent repair deficiency,
                     complementation group 6; excision repair
                     cross-complementation group 6"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6 isoform 1"
                     /protein_id="NP_001423630.1"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
                     /translation="MPHEEIPNSTQPQGQDWLPGQHVSADRDIPAGQETAGDSEAGKC
                     LSSPSCDHGPSTSAEACVLAATRWGPALLHIDRHQIPAVEPSAQALELQGLGVDVYDQ
                     AVLEEGVLQQVDSAMHEASRVAQRADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQ
                     AASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAILGGAEVHVELDHGSLEEEDA
                     EPGPSCLGSMLMPAQESAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYL
                     ADQAQLSFKRKKQAANKRTAKKAVVVSESSRGPNETKPNQRSQALSQTDKRLKKHIRK
                     LQRRALQFQGKVGLQRGKRPLEPEERPGAEGDTEGEESGSSPTDGEEEEEQEEEGVAV
                     LSSDDISYELKPLRKGQKYEKKVPVQEIDDDFFPSSEEEDEAVEGRGGGRKVSRRPDD
                     GDEDYYKQRLRRWNRLRLQDKEKLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTG
                     VRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTLIV
                     CPTTVMHQWVKEFHTWWPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSYSYIRL
                     MQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSL
                     FDFTFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRM
                     KSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGENQIFSGLVALRK
                     ICNHPDLFSGGPKNTSALPEDGLEEEQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFS
                     QSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLG
                     VNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIF
                     KQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQGTETSAIFAGTGSNIQTLKCHF
                     KKRTPPVLQMDPKRKKPLVSDTSVNGATVMEEKSQGSGATGSVPSTESGPLKSDRHTD
                     GSRASSVGFGEEADAGSTLEHLSGLSGDSPAVDHTSRLSAVASTSEKQGSSYEGECCQ
                     AQTGPVHLSEQTEGHFSKHKSKRKHDAAEEETTEKCPQPKQKAKNSRHHRDAKFEGTR
                     VPHLVKKRRYHQQTTEQESGAKDRSSDDYVLEKLFKKSVGVHSVVKHDAIIDGSSPDY
                     VLVEAEANRVAQDALKALRLSRQQCLGATSGVPTWTGHRGISGAPAGVKKRFGQKRNS
                     SLPVQRPSSLTERTQNMKKEGEAHTAEHFSGKEDGASSSGAPSSSSLLARMRARNHMI
                     LPERLESDGEQLAGAAAAAAPPCSTEHDALLVDMRNFIAFQAQVDGQASTQEILQAFE
                     SKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEYC"
     misc_feature    334..564
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    334..564
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    order(427..429,439..441)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    order(427..429,439..441)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    1033..3030
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    1033..3030
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    4291..4506
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    4291..4506
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    order(4291..4296,4303..4308,4312..4317,4324..4326,
                     4336..4341,4354..4359,4444..4446,4498..4506)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     misc_feature    order(4291..4296,4303..4308,4312..4317,4324..4326,
                     4336..4341,4354..4359,4444..4446,4498..4506)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     exon            510..630
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            631..742
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1469
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1595
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1754
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1890
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2061
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2238
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2355
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2451
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2667
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2778
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2898
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..2993
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3139
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3814
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..4019
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4092
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            4093..6137
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggcgca cgttctcacc tgcgcggcag acagggggct gtcgcggcgc ggaccagcct
       61 ctggcatctg cttctggttt gtagaggatg ccccatgagg aaatccccaa ctccactcaa
      121 cctcagggcc aagactggtt accaggtcag catgtcagtg ctgacagaga cataccagct
      181 gggcaggaga ctgctgggga ctcagaggcg gggaagtgcc tctcctctcc ttcctgtgac
      241 catgggccgt ccacatctgc tgaagcttgt gtactggcag ccacaaggtg ggggcccgcc
      301 ctgctgcaca tcgaccggca tcagattcct gcggtggagc ccagtgctca ggccctggag
      361 ctgcagggcc tgggtgtgga cgtctacgac caggccgtcc tggaggaagg tgtgcttcag
      421 caggtggaca gtgcaatgca tgaggccagc cgtgtggccc agcgtgctga tgcggagaaa
      481 gagtatcagt cagtcctgga cgacctcatg tcatgtacaa catccctgag gcaaatcaat
      541 aaaattatag agcaacttag ccctcaagct gccagcaaca gagacatcaa caggaaacta
      601 gattctgtga aacgacagaa gtacaacaag gaacaacagc taaagaagat aactgcaaaa
      661 cagaaacgtc tccaggccat tctcggagga gcggaggtcc atgtggaact ggatcatggc
      721 agcttagagg aggaagatgc agagccaggc ccatcatgtc tcggcagtat gctcatgcct
      781 gcccaggaga gcgcctggga agaacttatc cgcactggcc agatgacacc gttcggtacc
      841 ccagcccctc agaaacagga gaaaaagcct agaaaaataa tgctcaatga agcatcaggc
      901 tttgaaaaat atttggcaga ccaagcacaa ctttctttta aaaggaaaaa acaagctgct
      961 aataaaagaa cagctaaaaa agctgtggtt gtatctgagt caagccgagg accaaatgaa
     1021 actaagccaa accagagaag ccaagcgctc tctcagacag acaagcgcct gaagaagcac
     1081 atcaggaagc tccagaggag ggcgctgcag ttccagggca aagtgggatt gcaaaggggg
     1141 aagagacctc tggagcctga ggagaggcca ggggcagagg gagacactga gggtgaggag
     1201 tctgggtcct ctcccactga tggggaggaa gaggaagaac aagaggagga aggggtagcc
     1261 gttctgtctt ccgatgacat tagctatgaa ctgaagcctc ttcggaaagg acaaaaatac
     1321 gagaagaaag tcccagtgca ggagatcgac gatgacttct ttccaagttc tgaggaggaa
     1381 gatgaagctg tggaaggaag aggaggaggc cgcaaggtct ccaggcgccc agacgatgga
     1441 gatgaggatt attataaaca acgattaagg aggtggaata ggctgaggct gcaggacaaa
     1501 gagaagctga agcttgaaga cgattctgag gagagcgatg ctgagtttga cgaaggtttc
     1561 aaagtgccgg gttttctgtt caaaaagctc tttaagtatc agcagacagg tgttaggtgg
     1621 ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagacgaaat gggattgggc
     1681 aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat caggactcgc
     1741 ggttcaaatt acaggttcga gggactcggc cccactctca ttgtctgccc aacgacagtg
     1801 atgcatcagt gggtgaaaga attccacacg tggtggcctc cattcagagt ggcgattctg
     1861 cacgaaacag gctcctgtgc ccacagaaag gagaggctgg ttcgagatat tgttcattgt
     1921 catggagttt tgataacttc gtattcctac attcgactga tgcaagacga cattagcagg
     1981 catgactggc actacgtcat cttagacgaa ggacataaaa ttcgaaatcc aaatgctgca
     2041 gtcacccttg cttgcaaaca gttccggaca ccccatcgga tcatcttgtc gggctcaccg
     2101 atgcagaata acctgcgaga gctgtggtca ctcttcgact ttaccttccc aggaaagcta
     2161 ggcacgttgc ctgtgttcat ggagcagttc tctgtcccca tcaccatggg ggggtactcc
     2221 aatgcttccc cagtacaggt taaaactgcc tataagtgtg cgtgtgtctt gagagacacg
     2281 ataaacccgt acctactgcg aagaatgaaa tcagatgtca agatgagcct ttcgctgcca
     2341 gataaaaatg aacaggtctt attttgccgt ctaactgatg agcagcataa agtctaccag
     2401 aatttcatcg attccaaagc agtttacagg attctcaatg gagagaatca gattttctct
     2461 ggacttgtag ctctgaggaa gatctgcaac caccctgacc tcttttctgg cggtcccaag
     2521 aacaccagtg ctcttccaga ggatggactg gaggaggagc agttcggata ctggaaacgc
     2581 tctgggaaaa tgattgttgt tgagtctttg ctgaaaatct ggcacaagca gggtcagcgg
     2641 gtgctgctgt tttcccagtc aaggcagatg ctgcacatac tggaagtgtt cctgagagcc
     2701 cacaagtatt cctatctcaa gatggatggg accactacca tagcatccag gcagccgctg
     2761 attacaaaat acaatgagga cacgtccatc tttgtctttc ttctgaccac acgggtgggc
     2821 ggcttaggag tgaacctgac cggggccaac agagtcatca tctacgaccc tgactggaat
     2881 ccaagcaccg acacacaggc acgggagcga gcatggagga tcggccagaa gaagcaggtg
     2941 actgtctaca ggcttctgac ggccggcacc atagaggaaa agatctatca ccgacaaatc
     3001 ttcaagcaat ttttgacaaa cagagtgcta aaagacccta aacaaaggcg ctttttcaag
     3061 tccaatgatc tctatgagct gtttactctg actagtcctg atgcctccca gggcactgaa
     3121 acaagtgcta tttttgcagg aaccggatct aatattcaga cactgaaatg ccattttaaa
     3181 aagaggactc cgccagtcct acaaatggat cccaaacgca agaagcccct ggtttctgac
     3241 acatctgtaa atggtgccac tgtgatggaa gaaaaatctc aggggtcagg agctacgggc
     3301 agtgtccctt ctacagaaag tggccctttg aaaagtgacc gtcacacaga tgggagcaga
     3361 gccagcagtg ttggttttgg agaagaggca gatgcagggt ccacgctgga gcatctctca
     3421 gggctgagtg gagattctcc agcagttgac cacacatcca ggctgtcagc tgtggcgagc
     3481 accagtgaga agcagggctc ttcctatgaa ggggagtgct gccaggctca gacgggacct
     3541 gttcacctga gtgaacaaac ggaaggtcat ttctctaagc acaaatcaaa aaggaaacat
     3601 gatgcagcgg aggaagagac cacagagaag tgtccacagc ccaagcaaaa ggccaagaac
     3661 tccaggcatc acagagatgc taagtttgag ggaactcgag tcccacacct ggtgaagaag
     3721 aggcggtacc atcagcaaac cactgagcag gagagcggag ccaaggaccg gagcagtgat
     3781 gattatgttt tggaaaagct tttcaaaaaa tcagtgggcg tgcacagcgt cgtgaagcat
     3841 gatgccatca tagatgggtc cagtccggat tatgtgctgg tggaggcaga agccaacaga
     3901 gtggctcagg atgccttgaa agctctgagg ctctctcgtc agcagtgcct gggggcaaca
     3961 tctggtgttc ccacctggac tggccacagg ggtatttccg gtgcaccagc aggagtaaag
     4021 aaaaggttcg gtcagaaaag gaactccagc ctccctgtgc agcgtccttc gtcgctaaca
     4081 gagagaactc agaacatgaa gaaggagggg gaagctcaca ccgctgagca cttcagtggc
     4141 aaagaagatg gagcatcgtc gtctggagcc cccagttcct cctcgctctt ggccagaatg
     4201 cgagcacgaa accacatgat tttgccggag cgtttggaga gtgacggcga gcagcttgct
     4261 ggggctgcgg ctgcggctgc gcctccctgc agcacagagc acgacgccct tctggtggac
     4321 atgaggaact tcattgcttt ccaggctcag gtggatggcc aggccagcac tcaggaaatc
     4381 ctacaggcgt tcgaatccaa gctgtctgtg gcacagtcct gtgtcttccg agaactactg
     4441 aggaatctgt gcaatttcca tagaactcct ggtggtgaag ggatttggaa actgaagcca
     4501 gagtactgct aacagtgctg cttcctgaac tttttcaaat aggaatcttg gctcgtgtgt
     4561 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtaagt gtataagagt
     4621 atagctgcac ttggtgttta ctgtgtcatc tacctcaaga ctaaaacttg aagaagaaaa
     4681 taattggagg gtttttgttt ggtttggttt tcttttggtg gcactatgaa ttgttataaa
     4741 accagggacc tagcagttgt ttaatggagc aaatacatta cttaacccaa gagatgctgt
     4801 cagggagcac attctgtcta agagtagatc ttgattcttc ttattggtgc tgggaacgtg
     4861 tcttctcttt atccacgcca tcccataggg gacttcacgg tatctgataa ccttagtacc
     4921 ttgatacagt aagtatttat gacccactgg ccacatacag aaagatcctt gctatctgtc
     4981 aaatcattcc ctacgattaa ttcttcacag tacttttaaa gtagcaggtt tgggttttac
     5041 tgttggtctg ttttaaatgt tgctaacgac agtctggtgc cttgcacgtg ctaagcgagc
     5101 taagcgagca tgtgcttcac caccaggttc catccagttc atacatacgc atcaacgaag
     5161 gacgtctggc ttttcttctc tgtcatcatt gtgtaaggaa gggggagggg tttgtttaaa
     5221 taggtcagta acgtctggac ttcagcactt ggctcagaag gcagtcacac attttttctt
     5281 ctagttgtca gcctacaggg gaatggcgtt gttcttgtcc caggctgact cctgatctga
     5341 ctcactggtg tgagcttttg tgctgtgtct gtaatgcctg agatctacgt cagactgagc
     5401 tggagaaggt ataaacacct cttagatggc aagtgacctc ccatgagtaa gggaggagtc
     5461 catggtccag ctctgccact gacctgccca gcctggggag gttgactctg taaacacggt
     5521 tttccagcca agctgggaaa ctcagagacc agtgctctag gttaaagtac tttttaacaa
     5581 tgaacaatac ctttatacat taagctgcaa tctgattttt tgaacatgaa atactttgtg
     5641 tggtgtaaat agaattaatg tgttaaacat gttaaataat tgtaaataaa agactttaaa
     5701 attccagctt ttactgtatt gtcactgtta aagccttcaa gcgctcctgc cttcccaccc
     5761 tgtgccgatg gagctgcggt tccggagccc tgtgcagttg cccaggcatt tgcatggctg
     5821 ctggcgtggg ctgctgcttc gcttctgtgt gtcccctggg ccagtcactg ctcagctgac
     5881 aatcgtttct cagcctccct gcagcgaagt gtggccgcat gacagttcca ggcagtgaga
     5941 tggaaaacgc caacttgaag cttacacaaa gtcatggcat gcacgcccct gaaagttccc
     6001 tgttttgctg gtcgggatgt gtatgaaagc ctcgggtttc cgggtatttc aagagagggt
     6061 ggttggtctg ccagtcaaga acagctgtcc gtgaccagat actttggagt gaaataaatg
     6121 aatcttattt aacactg
//
LOCUS       NM_001436672            3340 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 2, mRNA.
ACCESSION   NM_001436672 XM_006252607
VERSION     NM_001436672.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3340)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3340)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3340)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3340)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3340)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3340)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3340)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3340)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3340)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3340)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252607.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.47295.1,
                                           SRR26643429.49782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000016.1  6453402-6453566
            166-195             JAXUCZ010000016.1  6453662-6453691
            196-250             JAXUCZ010000016.1  6453812-6453866
            251-383             JAXUCZ010000016.1  6454871-6455003
            384-503             JAXUCZ010000016.1  6455366-6455485
            504-565             JAXUCZ010000016.1  6455976-6456037
            566-708             JAXUCZ010000016.1  6456213-6456355
            709-787             JAXUCZ010000016.1  6456604-6456682
            788-911             JAXUCZ010000016.1  6457065-6457188
            912-1059            JAXUCZ010000016.1  6457443-6457590
            1060-1244           JAXUCZ010000016.1  6458022-6458206
            1245-1372           JAXUCZ010000016.1  6458575-6458702
            1373-1851           JAXUCZ010000016.1  6459242-6459720
            1852-2012           JAXUCZ010000016.1  6459835-6459995
            2013-2085           JAXUCZ010000016.1  6460433-6460505
            2086-3340           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3340
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..165
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     CDS             129..2219
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 2"
                     /protein_id="NP_001423601.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVY
                     GFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLN
                     CSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLS
                     AVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLAT
                     AGEPYHDIRFNLMAVVPDRRVKYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKS
                     QESQLPEESKPASSKSPFGLEAGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKL
                     VVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQ
                     YSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKL
                     QESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSP
                     IRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDG
                     VLSPLALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEK
                     YSPKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKP
                     DRRKRSRPYKAKRQ"
     misc_feature    141..827
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    141..827
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    <2010..2093
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    <2010..2093
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     exon            166..195
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..250
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..383
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..503
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..565
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..708
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..787
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..911
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1059
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1244
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1372
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1851
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2012
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2085
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..3340
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgt ggggctgaga agccccgagg gcggtgggcg
       61 ctcccggtgg gggcggcgcg gggttagcag ggcctggaca tggcgctgag agaccgctcc
      121 gcgggaagat gaataagggc tggctggagc tggagagtga cccgggcctc ttcaccctcc
      181 tggtggaaga tttcggtgtc aaaggggtgc aagtggagga gatctatgac cttcagagta
      241 aatgccaggg gcctgtatat ggatttatct tcctgttcaa atggatcgaa gagcgcaggt
      301 cccgccgcaa ggtttctacg ttggtggatg atacatctgt gattgatgat gacatcgtga
      361 atagcatgtt ctttgctcac cagctgattc ccaactcttg tgccactcac gccttgctga
      421 gcgtgcttct gaactgcagc aatgtggatt tggggcccac gctgagtcga atgaaggatt
      481 tcaccaaagg cttcagccct gagagcaaag gatatgcgat tggcaatgcc cctgaactgg
      541 ccaaggcaca taatagccat gccaggccag aaccacgtca ccttcctgag aaacagaatg
      601 gcctcagtgc agtgcggacc atggaggcgt ttcactttgt cagctatgtg cctatcacag
      661 gacggctctt tgaattggat gggttgaaag tctaccctat tgatcatggg ccctggggag
      721 aggatgagga gtggacagat aaagcccgaa gggtcatcat ggagcgaatc ggccttgcta
      781 ctgcagggga gccctaccat gacattcgct tcaacctgat ggcagtggtg cctgaccgca
      841 gggttaagta tgaggccagg ctgcatgtgc tgaaggggaa ccgacaaaca gtcctggagg
      901 ccctgcagca gctgattaga gtaacacagc cagagctgat tcagacccac aaatctcaag
      961 agtcacaact gcctgaggag agcaagccag ccagcagcaa gtctcccttt gggctagagg
     1021 cgggcagaac cccggcggcc tctgagtgca ctcacacaga tggtgcagag gaggtggctg
     1081 gttcgtgccc acaaactaca acccatagtc ctcccagcaa atctaagctg gtggtgaagc
     1141 cttcagggag cagcctcaat ggggttcccc caacccctac ccctattgtc cagcggctgc
     1201 cagcctttct agataatcac aattatgcca aatcccctat gcaggaggag gaagacctgg
     1261 cggcaggtgt gggccgcagc cgagttccag tccgacccca gcagtactct gatgatgagg
     1321 aggactatga ggatgaggag gaggatgtgc agaataccag ttctgccatc agatacaagc
     1381 ggaaggggac agggaagcca ggatcgttga gcaattcttc agatgggcag ctgtcagtgc
     1441 tgcagcccaa caccatcaat gtcttaactg agaagcttca agagtctcag aaagaccttt
     1501 caattcctct gtccatcaag actagcagtg gggctgggag tccagccgtg gctgtgccca
     1561 cacactcgca gccttcaccc acccctagca atgagagcac ggacacagcc tctgagattg
     1621 gcagtgcttt caactcaccc ttgcgctcac ccatccgctc agccaaccca acacggccct
     1681 ctagccctgt cacctctcac atctccaagg tgctctttgg agaagatgac agcctacttc
     1741 gtgttgactg catacgctac aaccgtgctg tccgtgacct gggtcctgtc attagcacgg
     1801 gcctgctgca ccttgctgag gatggtgtac tgagtcccct ggcactcaca gagggtggga
     1861 agggttcctc accttctacc agatcaagcc aaggcagcca ggggtccagc agcctagagg
     1921 agaaggaggt ggtggaagtc acagatagca gagacaagtc tgggctgaac aggtccagtg
     1981 agcccttgag tggagagaag tactcgccca agattgatga ccagcgaagg acccacaact
     2041 atgatgagtt catctgcacc ttcatatcca tgctggctca ggaaggaatg ctggccaacc
     2101 tggtggagca gaacatctca gtgcggcgcc gccaaggggt cagcattggt cggcttcaca
     2161 agcagcggaa gcctgatagg cggaaacgct ctcgccccta caaggccaaa cgccagtgag
     2221 gacctctagc cctgactctg cagcctctct tgccgcaagg ccctcaccag ggcccttcac
     2281 tgttcgactt ttccaagtat tactgaatag ttcagctaga gctcaggccc tgggagtagg
     2341 aatgggatgt gtattctgca ttatgctctg gggtctggca gggacaaggc agctccataa
     2401 tgctcaggaa gcagcagctg gaattggagg gtgctgtggc ctccacggcc atctgaggag
     2461 cagcaggata tatattctac ctgttggaga tgtctatttt tttgactttt ggccatcttg
     2521 ccactgtatt aacatggcca gcttcctgac tctgctttct ctcccagcag ctgtcattct
     2581 gctgggccca ggtctcttat aaccacagta ccagctggga aacccagaag gcattggtcc
     2641 tggtgctcta gcaccagcca ccagcctgtc cttgttgtga agaagcttgg cctactactc
     2701 ttgattcctt ctgggagagc gccaaactca gggacctggc tgctgagctg gaatgggcat
     2761 ggggtatcct agtaggatgt acagcctatc agggtcccac agctatcgtg gagacaagtg
     2821 tttgaactgt cctcgtacca cccagacttg ttagtgagtc agagcagggc tctggggctc
     2881 tttgccttca gtgttgtggc cctggccgtg ggcctacctt aggctcctaa tctccgtctc
     2941 tggggtccag aggagccact acttagcccc tcagtattac catgtctcct cttaggaatg
     3001 tcagaggcag ggctgctcga atgaggctgg cactattcaa ttctcccgac cgtgccagct
     3061 tccttggcct catgcaggta ctcagggtag gggacagggt caagaggagt tagaacttct
     3121 gtgttcccat agggcttgat gccagtgggg tagtaagcac agcactgctt caagctccag
     3181 gcccagatag ccctgtgccc tctgctagat acaggtgatc caagcaggcc ccttacctgt
     3241 acatagcaac tgtcgggggg atggtacagc agtccgaccc gctatagtgt ctgtaaatac
     3301 tgaatcagtg agtgaagaat aaaagtgtgc taataagtga
//
LOCUS       NM_001100538            3127 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 2, mRNA.
ACCESSION   NM_001100538 XM_001054606 XM_216517
VERSION     NM_001100538.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001100538.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166452.1, SRR26360186.1552365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2289           JAXUCZ010000005.1  140860181-140860252
            2290-2376           JAXUCZ010000005.1  140860729-140860815
            2377-2504           JAXUCZ010000005.1  140860911-140861038
            2505-2598           JAXUCZ010000005.1  140862618-140862711
            2599-2729           JAXUCZ010000005.1  140862797-140862927
            2730-2826           JAXUCZ010000005.1  140863198-140863294
            2827-3127           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3127
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2819
                     /gene="Pabpc4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 2"
                     /protein_id="NP_001094008.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVPNLAP
                     RATVAAAAPRAVAPYKYASNVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQE
                     QKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQ
                     AHHAKKEAAQKVGTVAAATS"
     misc_feature    915..2756
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2756
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2289
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2376
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2504
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2598
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2729
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2826
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3127
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg gtctgagtgc ccggaccgct tggctatgga ctttggtggg gctggtgccg
     2341 cccagcaagg gctgactgac agctgccagt ctggaggcgt ccctacggct gtgccaaacc
     2401 ttgcacctcg tgctacagtc gctgctgctg ctcccagggc tgtggctcca tacaagtatg
     2461 cctccaatgt ccgcagccct caccctgcca ttcagccgct gcaggccccc cagcctgcag
     2521 tccatgtcca gggtcaagaa cccctgactg cctccatgct ggctgcagct cctccccagg
     2581 agcagaagca gatgctgggg gagcgtttgt tcccacttat ccaaacaatg cattcaaacc
     2641 tggctggaaa aattacaggg atgctgctag aaatcgacaa ctctgagctg ctccacatgc
     2701 tggagtcccc cgagtccctc cgttccaagg tggatgaagc tgtggcagtc ctgcaggctc
     2761 atcatgccaa gaaagaagct gcccagaagg tgggcactgt tgctgctgct acctcttaaa
     2821 ccagaagagt caaaagccaa ataacccctc acggcattca gctgaggtct gaagacttcc
     2881 tagtttgtct gtggacctct ttcaagaacc aagttacaaa ttcaacaggt cattttgtat
     2941 caaaaggtca attatgaagc acctagaatt tttcaattat aagaatatat tctctgggtt
     3001 ctgttgtggc ccagatgatg gtaacttttt tttctattat gagttctgtt ttttttcccc
     3061 tctcccagaa attggttttg atgtacccaa gacttaagtt tctcaataaa ggaaataaaa
     3121 tctccaa
//
LOCUS       NM_001107292            3472 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 7, mRNA.
ACCESSION   NM_001107292 XM_001058224 XM_224614
VERSION     NM_001107292.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3472)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3472)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3472)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3472)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3472)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3472)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3472)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3472)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3472)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3472)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001107292.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.37704.1,
                                           SRR26643299.58128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000016.1  6453402-6453566
            166-234             JAXUCZ010000016.1  6453662-6453730
            235-289             JAXUCZ010000016.1  6453812-6453866
            290-422             JAXUCZ010000016.1  6454871-6455003
            423-542             JAXUCZ010000016.1  6455366-6455485
            543-604             JAXUCZ010000016.1  6455976-6456037
            605-747             JAXUCZ010000016.1  6456213-6456355
            748-826             JAXUCZ010000016.1  6456604-6456682
            827-950             JAXUCZ010000016.1  6457065-6457188
            951-1098            JAXUCZ010000016.1  6457443-6457590
            1099-1283           JAXUCZ010000016.1  6458022-6458206
            1284-1411           JAXUCZ010000016.1  6458575-6458702
            1412-1890           JAXUCZ010000016.1  6459242-6459720
            1891-2051           JAXUCZ010000016.1  6459835-6459995
            2052-2144           JAXUCZ010000016.1  6460240-6460332
            2145-2217           JAXUCZ010000016.1  6460433-6460505
            2218-3472           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3472
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..165
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     CDS             129..2351
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 4 is encoded by transcript variant 7;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 4"
                     /protein_id="NP_001100762.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MNKGWLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEE
                     IYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPN
                     SCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARP
                     EPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDK
                     ARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLHVLKGNRQTVLEALQQLI
                     RVTQPELIQTHKSQESQLPEESKPASSKSPFGLEAGRTPAASECTHTDGAEEVAGSCP
                     QTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEEDLAA
                     GVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSV
                     LQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTAS
                     EIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGP
                     VISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKS
                     GLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNY
                     DEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
                     "
     misc_feature    141..866
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    141..866
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    333..347
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Arg-finger motif.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    order(420..422,438..440,672..674,717..719)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(420..422,438..440,672..674,717..719)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(420..422,438..440,672..674,717..719)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(420..422,438..440,672..674,717..719)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    420..422
                     /gene="Bap1"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01393; propagated
                     from UniProtKB/Swiss-Prot (D3ZHS6.2); other site"
     misc_feature    717..719
                     /gene="Bap1"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01393; propagated
                     from UniProtKB/Swiss-Prot (D3ZHS6.2); other site"
     misc_feature    984..1220
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1041..1043
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1254..1265
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: HBM-like motif.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    1272..1274
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1281..1472
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1347..1349
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1551..1733
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1638..1640
                     /gene="Bap1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1722..1724
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1770..1772
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1884..2033
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1914..1916
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1947..2324
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with BRCA1.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    1950..1952
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    2085..2219
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with YY1.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2088..2225
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2088..2225
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2256..2327
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Classical bipartite Nuclear localization signal
                     (NLS). /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2256..2264
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with nucleosomal DNA forming a DNA
                     clamp with ASXL1. /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2271..2348
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2298..2348
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Positively charged C-terminal extension (CTE).
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2310..2333
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Non-classical PY-nuclear localization signal
                     (PY-NLS). /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2310..2327
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     exon            166..234
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..289
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..422
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..542
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..604
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..747
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..826
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..950
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1098
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1283
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1411
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1890
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2051
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2144
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2217
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..3472
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgt ggggctgaga agccccgagg gcggtgggcg
       61 ctcccggtgg gggcggcgcg gggttagcag ggcctggaca tggcgctgag agaccgctcc
      121 gcgggaagat gaataagggc tggctggagc tggagagtga cccgggcctc ttcaccctcc
      181 tggtggaaga tttcggtaag aaccccttta cccccgatcg tcgggccctg gctggtgtca
      241 aaggggtgca agtggaggag atctatgacc ttcagagtaa atgccagggg cctgtatatg
      301 gatttatctt cctgttcaaa tggatcgaag agcgcaggtc ccgccgcaag gtttctacgt
      361 tggtggatga tacatctgtg attgatgatg acatcgtgaa tagcatgttc tttgctcacc
      421 agctgattcc caactcttgt gccactcacg ccttgctgag cgtgcttctg aactgcagca
      481 atgtggattt ggggcccacg ctgagtcgaa tgaaggattt caccaaaggc ttcagccctg
      541 agagcaaagg atatgcgatt ggcaatgccc ctgaactggc caaggcacat aatagccatg
      601 ccaggccaga accacgtcac cttcctgaga aacagaatgg cctcagtgca gtgcggacca
      661 tggaggcgtt tcactttgtc agctatgtgc ctatcacagg acggctcttt gaattggatg
      721 ggttgaaagt ctaccctatt gatcatgggc cctggggaga ggatgaggag tggacagata
      781 aagcccgaag ggtcatcatg gagcgaatcg gccttgctac tgcaggggag ccctaccatg
      841 acattcgctt caacctgatg gcagtggtgc ctgaccgcag ggttaagtat gaggccaggc
      901 tgcatgtgct gaaggggaac cgacaaacag tcctggaggc cctgcagcag ctgattagag
      961 taacacagcc agagctgatt cagacccaca aatctcaaga gtcacaactg cctgaggaga
     1021 gcaagccagc cagcagcaag tctccctttg ggctagaggc gggcagaacc ccggcggcct
     1081 ctgagtgcac tcacacagat ggtgcagagg aggtggctgg ttcgtgccca caaactacaa
     1141 cccatagtcc tcccagcaaa tctaagctgg tggtgaagcc ttcagggagc agcctcaatg
     1201 gggttccccc aacccctacc cctattgtcc agcggctgcc agcctttcta gataatcaca
     1261 attatgccaa atcccctatg caggaggagg aagacctggc ggcaggtgtg ggccgcagcc
     1321 gagttccagt ccgaccccag cagtactctg atgatgagga ggactatgag gatgaggagg
     1381 aggatgtgca gaataccagt tctgccatca gatacaagcg gaaggggaca gggaagccag
     1441 gatcgttgag caattcttca gatgggcagc tgtcagtgct gcagcccaac accatcaatg
     1501 tcttaactga gaagcttcaa gagtctcaga aagacctttc aattcctctg tccatcaaga
     1561 ctagcagtgg ggctgggagt ccagccgtgg ctgtgcccac acactcgcag ccttcaccca
     1621 cccctagcaa tgagagcacg gacacagcct ctgagattgg cagtgctttc aactcaccct
     1681 tgcgctcacc catccgctca gccaacccaa cacggccctc tagccctgtc acctctcaca
     1741 tctccaaggt gctctttgga gaagatgaca gcctacttcg tgttgactgc atacgctaca
     1801 accgtgctgt ccgtgacctg ggtcctgtca ttagcacggg cctgctgcac cttgctgagg
     1861 atggtgtact gagtcccctg gcactcacag agggtgggaa gggttcctca ccttctacca
     1921 gatcaagcca aggcagccag gggtccagca gcctagagga gaaggaggtg gtggaagtca
     1981 cagatagcag agacaagtct gggctgaaca ggtccagtga gcccttgagt ggagagaagt
     2041 actcgcccaa ggagctgtta gcactgttaa agtgtgtaga ggccgagatt gcaaactatg
     2101 aggcctgtct caaggaggag gtggagaaaa ggaagaagtt caagattgat gaccagcgaa
     2161 ggacccacaa ctatgatgag ttcatctgca ccttcatatc catgctggct caggaaggaa
     2221 tgctggccaa cctggtggag cagaacatct cagtgcggcg ccgccaaggg gtcagcattg
     2281 gtcggcttca caagcagcgg aagcctgata ggcggaaacg ctctcgcccc tacaaggcca
     2341 aacgccagtg aggacctcta gccctgactc tgcagcctct cttgccgcaa ggccctcacc
     2401 agggcccttc actgttcgac ttttccaagt attactgaat agttcagcta gagctcaggc
     2461 cctgggagta ggaatgggat gtgtattctg cattatgctc tggggtctgg cagggacaag
     2521 gcagctccat aatgctcagg aagcagcagc tggaattgga gggtgctgtg gcctccacgg
     2581 ccatctgagg agcagcagga tatatattct acctgttgga gatgtctatt tttttgactt
     2641 ttggccatct tgccactgta ttaacatggc cagcttcctg actctgcttt ctctcccagc
     2701 agctgtcatt ctgctgggcc caggtctctt ataaccacag taccagctgg gaaacccaga
     2761 aggcattggt cctggtgctc tagcaccagc caccagcctg tccttgttgt gaagaagctt
     2821 ggcctactac tcttgattcc ttctgggaga gcgccaaact cagggacctg gctgctgagc
     2881 tggaatgggc atggggtatc ctagtaggat gtacagccta tcagggtccc acagctatcg
     2941 tggagacaag tgtttgaact gtcctcgtac cacccagact tgttagtgag tcagagcagg
     3001 gctctggggc tctttgcctt cagtgttgtg gccctggccg tgggcctacc ttaggctcct
     3061 aatctccgtc tctggggtcc agaggagcca ctacttagcc cctcagtatt accatgtctc
     3121 ctcttaggaa tgtcagaggc agggctgctc gaatgaggct ggcactattc aattctcccg
     3181 accgtgccag cttccttggc ctcatgcagg tactcagggt aggggacagg gtcaagagga
     3241 gttagaactt ctgtgttccc atagggcttg atgccagtgg ggtagtaagc acagcactgc
     3301 ttcaagctcc aggcccagat agccctgtgc cctctgctag atacaggtga tccaagcagg
     3361 ccccttacct gtacatagca actgtcgggg ggatggtaca gcagtccgac ccgctatagt
     3421 gtctgtaaat actgaatcag tgagtgaaga ataaaagtgt gctaataagt ga
//
LOCUS       NM_001436675            3361 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 5, mRNA.
ACCESSION   NM_001436675
VERSION     NM_001436675.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3361)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3361)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3361)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3361)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.35012.1,
                                           SRR26360172.634980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000016.1  6453307-6453399
            94-123              JAXUCZ010000016.1  6453662-6453691
            124-178             JAXUCZ010000016.1  6453812-6453866
            179-311             JAXUCZ010000016.1  6454871-6455003
            312-431             JAXUCZ010000016.1  6455366-6455485
            432-493             JAXUCZ010000016.1  6455976-6456037
            494-636             JAXUCZ010000016.1  6456213-6456355
            637-715             JAXUCZ010000016.1  6456604-6456682
            716-839             JAXUCZ010000016.1  6457065-6457188
            840-987             JAXUCZ010000016.1  6457443-6457590
            988-1172            JAXUCZ010000016.1  6458022-6458206
            1173-1300           JAXUCZ010000016.1  6458575-6458702
            1301-1779           JAXUCZ010000016.1  6459242-6459720
            1780-1940           JAXUCZ010000016.1  6459835-6459995
            1941-2033           JAXUCZ010000016.1  6460240-6460332
            2034-2106           JAXUCZ010000016.1  6460433-6460505
            2107-3361           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3361
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..93
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     exon            94..123
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..178
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..311
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2240
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 5;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 3"
                     /protein_id="NP_001423604.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFS
                     PESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLF
                     ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRV
                     KYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLE
                     AGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQ
                     RLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSA
                     IRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGS
                     PAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVL
                     FGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSS
                     QGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYE
                     ACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS
                     IGRLHKQRKPDRRKRSRPYKAKRQ"
     misc_feature    <294..755
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    <294..755
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    order(309..311,327..329,561..563,606..608)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(309..311,327..329,561..563,606..608)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(309..311,327..329,561..563,606..608)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(309..311,327..329,561..563,606..608)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    1977..2114
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    1977..2114
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     exon            312..431
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..493
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..636
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..715
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..839
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..987
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1172
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1300
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1779
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1940
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2033
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2106
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..3361
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctgcgc gcgcgcatcc ggcctccgcg caggcggaag gccagccccg gattaggctc
       61 gtcgtgtgtg atgacgttgt actcccggcg cgggcctctt caccctcctg gtggaagatt
      121 tcggtgtcaa aggggtgcaa gtggaggaga tctatgacct tcagagtaaa tgccaggggc
      181 ctgtatatgg atttatcttc ctgttcaaat ggatcgaaga gcgcaggtcc cgccgcaagg
      241 tttctacgtt ggtggatgat acatctgtga ttgatgatga catcgtgaat agcatgttct
      301 ttgctcacca gctgattccc aactcttgtg ccactcacgc cttgctgagc gtgcttctga
      361 actgcagcaa tgtggatttg gggcccacgc tgagtcgaat gaaggatttc accaaaggct
      421 tcagccctga gagcaaagga tatgcgattg gcaatgcccc tgaactggcc aaggcacata
      481 atagccatgc caggccagaa ccacgtcacc ttcctgagaa acagaatggc ctcagtgcag
      541 tgcggaccat ggaggcgttt cactttgtca gctatgtgcc tatcacagga cggctctttg
      601 aattggatgg gttgaaagtc taccctattg atcatgggcc ctggggagag gatgaggagt
      661 ggacagataa agcccgaagg gtcatcatgg agcgaatcgg ccttgctact gcaggggagc
      721 cctaccatga cattcgcttc aacctgatgg cagtggtgcc tgaccgcagg gttaagtatg
      781 aggccaggct gcatgtgctg aaggggaacc gacaaacagt cctggaggcc ctgcagcagc
      841 tgattagagt aacacagcca gagctgattc agacccacaa atctcaagag tcacaactgc
      901 ctgaggagag caagccagcc agcagcaagt ctccctttgg gctagaggcg ggcagaaccc
      961 cggcggcctc tgagtgcact cacacagatg gtgcagagga ggtggctggt tcgtgcccac
     1021 aaactacaac ccatagtcct cccagcaaat ctaagctggt ggtgaagcct tcagggagca
     1081 gcctcaatgg ggttccccca acccctaccc ctattgtcca gcggctgcca gcctttctag
     1141 ataatcacaa ttatgccaaa tcccctatgc aggaggagga agacctggcg gcaggtgtgg
     1201 gccgcagccg agttccagtc cgaccccagc agtactctga tgatgaggag gactatgagg
     1261 atgaggagga ggatgtgcag aataccagtt ctgccatcag atacaagcgg aaggggacag
     1321 ggaagccagg atcgttgagc aattcttcag atgggcagct gtcagtgctg cagcccaaca
     1381 ccatcaatgt cttaactgag aagcttcaag agtctcagaa agacctttca attcctctgt
     1441 ccatcaagac tagcagtggg gctgggagtc cagccgtggc tgtgcccaca cactcgcagc
     1501 cttcacccac ccctagcaat gagagcacgg acacagcctc tgagattggc agtgctttca
     1561 actcaccctt gcgctcaccc atccgctcag ccaacccaac acggccctct agccctgtca
     1621 cctctcacat ctccaaggtg ctctttggag aagatgacag cctacttcgt gttgactgca
     1681 tacgctacaa ccgtgctgtc cgtgacctgg gtcctgtcat tagcacgggc ctgctgcacc
     1741 ttgctgagga tggtgtactg agtcccctgg cactcacaga gggtgggaag ggttcctcac
     1801 cttctaccag atcaagccaa ggcagccagg ggtccagcag cctagaggag aaggaggtgg
     1861 tggaagtcac agatagcaga gacaagtctg ggctgaacag gtccagtgag cccttgagtg
     1921 gagagaagta ctcgcccaag gagctgttag cactgttaaa gtgtgtagag gccgagattg
     1981 caaactatga ggcctgtctc aaggaggagg tggagaaaag gaagaagttc aagattgatg
     2041 accagcgaag gacccacaac tatgatgagt tcatctgcac cttcatatcc atgctggctc
     2101 aggaaggaat gctggccaac ctggtggagc agaacatctc agtgcggcgc cgccaagggg
     2161 tcagcattgg tcggcttcac aagcagcgga agcctgatag gcggaaacgc tctcgcccct
     2221 acaaggccaa acgccagtga ggacctctag ccctgactct gcagcctctc ttgccgcaag
     2281 gccctcacca gggcccttca ctgttcgact tttccaagta ttactgaata gttcagctag
     2341 agctcaggcc ctgggagtag gaatgggatg tgtattctgc attatgctct ggggtctggc
     2401 agggacaagg cagctccata atgctcagga agcagcagct ggaattggag ggtgctgtgg
     2461 cctccacggc catctgagga gcagcaggat atatattcta cctgttggag atgtctattt
     2521 ttttgacttt tggccatctt gccactgtat taacatggcc agcttcctga ctctgctttc
     2581 tctcccagca gctgtcattc tgctgggccc aggtctctta taaccacagt accagctggg
     2641 aaacccagaa ggcattggtc ctggtgctct agcaccagcc accagcctgt ccttgttgtg
     2701 aagaagcttg gcctactact cttgattcct tctgggagag cgccaaactc agggacctgg
     2761 ctgctgagct ggaatgggca tggggtatcc tagtaggatg tacagcctat cagggtccca
     2821 cagctatcgt ggagacaagt gtttgaactg tcctcgtacc acccagactt gttagtgagt
     2881 cagagcaggg ctctggggct ctttgccttc agtgttgtgg ccctggccgt gggcctacct
     2941 taggctccta atctccgtct ctggggtcca gaggagccac tacttagccc ctcagtatta
     3001 ccatgtctcc tcttaggaat gtcagaggca gggctgctcg aatgaggctg gcactattca
     3061 attctcccga ccgtgccagc ttccttggcc tcatgcaggt actcagggta ggggacaggg
     3121 tcaagaggag ttagaacttc tgtgttccca tagggcttga tgccagtggg gtagtaagca
     3181 cagcactgct tcaagctcca ggcccagata gccctgtgcc ctctgctaga tacaggtgat
     3241 ccaagcaggc cccttacctg tacatagcaa ctgtcggggg gatggtacag cagtccgacc
     3301 cgctatagtg tctgtaaata ctgaatcagt gagtgaagaa taaaagtgtg ctaataagtg
     3361 a
//
LOCUS       NM_001436691            1740 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 7, mRNA.
ACCESSION   NM_001436691
VERSION     NM_001436691.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.47354.1,
                                           SRR26643299.58188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-550             JAXUCZ010000016.1  7308347-7308453
            551-692             JAXUCZ010000016.1  7309595-7309736
            693-801             JAXUCZ010000016.1  7326003-7326111
            802-1740            JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1740
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..956
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 3 is encoded by transcript variant 7;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 3"
                     /protein_id="NP_001423620.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKKNILDLVHEFPEKIACSF
                     HVTKQTTQISSELKPYVTDGRITEKEIREHISAETLFYVCGPPPMTDFFSKHLESSHV
                     PKEHICFEKWW"
     misc_feature    468..944
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    468..944
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..692
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            693..801
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1740
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gaggtcatgg ctgcagctaa ggtgtgtgag atcactcacg
      481 agtctccatc agtgaagagc ctccgtttgc ttgttgctga taaagacttt tccttcaagg
      541 ctggccagtg ggttgatttc ttcatcccag gagtttcagt ggttggtggg ttttcaattt
      601 gctccagtcc ccaacagcta gaacgagaga gaataataga attggcagtg aaatacacga
      661 accatcctcc tgctgtctgg gttcacaata agaaaaatat cctcgactta gtacatgagt
      721 ttcctgagaa gattgcctgc agttttcacg ttacaaaaca gacgacccaa atcagttctg
      781 aacttaagcc ttatgtcaca gatggaagaa taacagagaa ggagataaga gagcacattt
      841 cggcagagac tctgttctat gtctgcggcc cacctccaat gacagacttt ttctctaagc
      901 atctggaaag cagccacgtt cccaaggaac acatctgctt tgagaagtgg tggtaggagc
      961 aggcacagaa gacctgagag ccgctcagga cagtgagaac cagcaacaga gtcacacgag
     1021 aaacttcccg cagacttcat tggtggcact atttttcact atattgattt ttctttcatt
     1081 aattatccta tgatagttca ttattacaga atttctgacc tttggggaaa agaccatgct
     1141 caacccaatt gtaattaaaa gatttactga tgagctgctg gcaggaagac aggctgagag
     1201 ccagatttga gatggccata aataaaagag ggtgggggga aaggtttccc aaagggaaaa
     1261 ccatggggag gctcacggta tctatgcaag caggcagact ctggcctgtt ctgccaagat
     1321 taagtgggta aagcaactgg aaacaatctg ggtgtctgca cacgcaagtt acagaagctg
     1381 aaaacggcct ccatagccag gagaagctca cagctgtgcg tttctgggga cccctgagcc
     1441 agggctgttt tctgggaccc cgtctttctg gaattttgag tctatggcga gcagtcatca
     1501 gtactaagat ggagggaggc ctagaaaaaa atagtttctc gagttggcct ttacaccacg
     1561 aactgattaa tacaggtttt tcttttgccc tttgggggca aattagtcta attatgttaa
     1621 ttaaaggaaa gtgtgggttt tgtgtgaact gtatacttct ctaaataatt ggacagaaat
     1681 tcataaaatt tatgtttact gaatttataa ttttaaatac attctttatt ttgaaatgtc
//
LOCUS       NR_199180               1824 bp    RNA     linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 11, non-coding RNA.
ACCESSION   NR_199180
VERSION     NR_199180.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.46344.1,
                                           SRR26360190.1339766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-365             JAXUCZ010000016.1  7305064-7305184
            366-429             JAXUCZ010000016.1  7305489-7305552
            430-536             JAXUCZ010000016.1  7308347-7308453
            537-678             JAXUCZ010000016.1  7309595-7309736
            679-776             JAXUCZ010000016.1  7324159-7324256
            777-885             JAXUCZ010000016.1  7326003-7326111
            886-1824            JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1824
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     misc_RNA        1..1824
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /product="oxidoreductase NAD-binding domain containing 1,
                     transcript variant 11"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            245..365
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            366..429
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            430..536
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            537..678
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            679..776
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            777..885
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1824
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcaggcagca ccatggccca tgtcttgatt cctgggttgt ctcgaggctc tgtgggagcc
      301 atctgcactc aggctgcttc gtgggcactg cctaccagca ctctgcgttc ccttacctta
      361 gccagcgtaa tgagatccag aaggaaaact gaccacctag agagaaccgc cactgtcctc
      421 cgccgggagg tcatggctgc agctaaggtg tgtgagatca ctcacgagtc tccatcagtg
      481 aagagcctcc gtttgcttgt tgctgataaa gacttttcct tcaaggctgg ccagtgggtt
      541 gatttcttca tcccaggagt ttcagtggtt ggtgggtttt caatttgctc cagtccccaa
      601 cagctagaac gagagagaat aatagaattg gcagtgaaat acacgaacca tcctcctgct
      661 gtctgggttc acaataagat ctccaccggg accacaaaga aaaaaggaga ggctatgata
      721 taggaacaat aaaactgttc tacagcgcaa agaacaccag tgaactcctg tttaagaaaa
      781 atatcctcga cttagtacat gagtttcctg agaagattgc ctgcagtttt cacgttacaa
      841 aacagacgac ccaaatcagt tctgaactta agccttatgt cacagatgga agaataacag
      901 agaaggagat aagagagcac atttcggcag agactctgtt ctatgtctgc ggcccacctc
      961 caatgacaga ctttttctct aagcatctgg aaagcagcca cgttcccaag gaacacatct
     1021 gctttgagaa gtggtggtag gagcaggcac agaagacctg agagccgctc aggacagtga
     1081 gaaccagcaa cagagtcaca cgagaaactt cccgcagact tcattggtgg cactattttt
     1141 cactatattg atttttcttt cattaattat cctatgatag ttcattatta cagaatttct
     1201 gacctttggg gaaaagacca tgctcaaccc aattgtaatt aaaagattta ctgatgagct
     1261 gctggcagga agacaggctg agagccagat ttgagatggc cataaataaa agagggtggg
     1321 gggaaaggtt tcccaaaggg aaaaccatgg ggaggctcac ggtatctatg caagcaggca
     1381 gactctggcc tgttctgcca agattaagtg ggtaaagcaa ctggaaacaa tctgggtgtc
     1441 tgcacacgca agttacagaa gctgaaaacg gcctccatag ccaggagaag ctcacagctg
     1501 tgcgtttctg gggacccctg agccagggct gttttctggg accccgtctt tctggaattt
     1561 tgagtctatg gcgagcagtc atcagtacta agatggaggg aggcctagaa aaaaatagtt
     1621 tctcgagttg gcctttacac cacgaactga ttaatacagg tttttctttt gccctttggg
     1681 ggcaaattag tctaattatg ttaattaaag gaaagtgtgg gttttgtgtg aactgtatac
     1741 ttctctaaat aattggacag aaattcataa aatttatgtt tactgaattt ataattttaa
     1801 atacattctt tattttgaaa tgtc
//
LOCUS       NM_001436591            9161 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus nuclear factor I/A (Nfia), transcript variant 1,
            mRNA.
ACCESSION   NM_001436591 XM_063287181
VERSION     NM_001436591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9161)
  AUTHORS   Ding,B., Wang,W., Selvakumar,T., Xi,H.S., Zhu,H., Chow,C.W.,
            Horton,J.D., Gronostajski,R.M. and Kilpatrick,D.L.
  TITLE     Temporal regulation of nuclear factor one occupancy by
            calcineurin/NFAT governs a voltage-sensitive developmental switch
            in late maturing neurons
  JOURNAL   J Neurosci 33 (7), 2860-2872 (2013)
   PUBMED   23407945
REFERENCE   2  (bases 1 to 9161)
  AUTHORS   Riffel,A.K., Schuenemann,E. and Vyhlidal,C.A.
  TITLE     Regulation of the CYP3A4 and CYP3A7 promoters by members of the
            nuclear factor I transcription factor family
  JOURNAL   Mol Pharmacol 76 (5), 1104-1114 (2009)
   PUBMED   19706729
REFERENCE   3  (bases 1 to 9161)
  AUTHORS   Royland,J.E. and Kodavanti,P.R.
  TITLE     Gene expression profiles following exposure to a developmental
            neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s)
            of action
  JOURNAL   Toxicol Appl Pharmacol 231 (2), 179-196 (2008)
   PUBMED   18602130
REFERENCE   4  (bases 1 to 9161)
  AUTHORS   Lu,W., Quintero-Rivera,F., Fan,Y., Alkuraya,F.S., Donovan,D.J.,
            Xi,Q., Turbe-Doan,A., Li,Q.G., Campbell,C.G., Shanske,A.L.,
            Sherr,E.H., Ahmad,A., Peters,R., Rilliet,B., Parvex,P.,
            Bassuk,A.G., Harris,D.J., Ferguson,H., Kelly,C., Walsh,C.A.,
            Gronostajski,R.M., Devriendt,K., Higgins,A., Ligon,A.H.,
            Quade,B.J., Morton,C.C., Gusella,J.F. and Maas,R.L.
  TITLE     NFIA haploinsufficiency is associated with a CNS malformation
            syndrome and urinary tract defects
  JOURNAL   PLoS Genet 3 (5), e80 (2007)
   PUBMED   17530927
REFERENCE   5  (bases 1 to 9161)
  AUTHORS   Lin,Y.L., Wang,Y.H. and Lee,H.J.
  TITLE     Transcriptional regulation of the human TR2 orphan receptor gene by
            nuclear factor 1-A
  JOURNAL   Biochem Biophys Res Commun 350 (2), 430-436 (2006)
   PUBMED   17010934
REFERENCE   6  (bases 1 to 9161)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   7  (bases 1 to 9161)
  AUTHORS   Osada,S., Daimon,S., Ikeda,T., Nishihara,T., Yano,K., Yamasaki,M.
            and Imagawa,M.
  TITLE     Nuclear factor 1 family proteins bind to the silencer element in
            the rat glutathione transferase P gene
  JOURNAL   J Biochem 121 (2), 355-363 (1997)
   PUBMED   9089412
REFERENCE   8  (bases 1 to 9161)
  AUTHORS   Monaci,P., Nuzzo,M., Stampfli,S., Tollervey,D., De Simone,V. and
            Nicosia,A.
  TITLE     A complex interplay of positive and negative elements is
            responsible for the different transcriptional activity of liver NF1
            variants
  JOURNAL   Mol Biol Rep 21 (3), 147-158 (1995)
   PUBMED   8832903
REFERENCE   9  (bases 1 to 9161)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   10 (bases 1 to 9161)
  AUTHORS   Paonessa,G., Gounari,F., Frank,R. and Cortese,R.
  TITLE     Purification of a NF1-like DNA-binding protein from rat liver and
            cloning of the corresponding cDNA
  JOURNAL   EMBO J 7 (10), 3115-3123 (1988)
   PUBMED   3053160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 17, 2025 this sequence version replaced XM_063287181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF112455.1, SRR26360194.1672187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000005.1  117359296-117359425
            131-662             JAXUCZ010000005.1  117562518-117563049
            663-728             JAXUCZ010000005.1  117734267-117734332
            729-803             JAXUCZ010000005.1  117778110-117778184
            804-921             JAXUCZ010000005.1  117792897-117793014
            922-1049            JAXUCZ010000005.1  117799369-117799496
            1050-1178           JAXUCZ010000005.1  117820459-117820587
            1179-1357           JAXUCZ010000005.1  117842862-117843040
            1358-1523           JAXUCZ010000005.1  117845130-117845295
            1524-1615           JAXUCZ010000005.1  117860721-117860812
            1616-9161           JAXUCZ010000005.1  117889846-117897391
FEATURES             Location/Qualifiers
     source          1..9161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..9161
                     /gene="Nfia"
                     /note="nuclear factor I/A"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
     exon            1..130
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="Nfia"
                     /note="upstream in-frame stop codon"
     CDS             35..1633
                     /gene="Nfia"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor 1 A-type; CTF; NF1-A; NFI-A; NF-I/A;
                     nuclear factor 1/A; TGGCA-binding protein;
                     CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 A-type isoform 1"
                     /protein_id="NP_001423520.1"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
                     /translation="MKLADSVMAGKASDGSIKWQLCYDISARTWWMDEFHPFIEALLP
                     HVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKL
                     RKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILF
                     KGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPS
                     QPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSS
                     YYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWH
                     EVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLH
                     FPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKV
                     HNPFLPTPMLPPPPPPPMARPVPLPMPDTKPPTTSTEGGAASPTSPTYSTPSTSPANR
                     FVSVGPRDPSFVNIPQQTQSWYLG"
     misc_feature    131..241
                     /gene="Nfia"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:463134"
     misc_feature    131..241
                     /gene="Nfia"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:463134"
     misc_feature    305..619
                     /gene="Nfia"
                     /note="MH1 domain; Region: MH1; pfam03165"
                     /db_xref="CDD:460833"
     misc_feature    305..619
                     /gene="Nfia"
                     /note="MH1 domain; Region: MH1; pfam03165"
                     /db_xref="CDD:460833"
     misc_feature    743..1606
                     /gene="Nfia"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:459967"
     misc_feature    743..1606
                     /gene="Nfia"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:459967"
     exon            131..662
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            663..728
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            729..803
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            804..921
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1049
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1178
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1357
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1523
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1615
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..9161
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaggtgtc ttatctcccg tgagttagca tcagatgaag cttgctgaca gcgtaatggc
       61 agggaaagct tccgacggct ccatcaaatg gcagctttgc tacgacatct cggccagaac
      121 ttggtggatg gatgagtttc atcctttcat tgaagcactt ctgccccatg tccgcgcctt
      181 cgcctacaca tggttcaacc tgcaggcccg aaagcggaaa tacttcaaaa agcatgagaa
      241 gcgcatgtcg aaagaagagg agagggctgt gaaggatgaa ctgctaagtg agaagcctga
      301 ggtcaagcaa aagtgggctt cccgacttct ggccaagtta cggaaagata tccgacccga
      361 gtaccgagag gattttgttc ttacagttac agggaaaaaa cctccatgct gtgttctttc
      421 caacccagac cagaaaggca agatgcggag aattgactgc ctccgccagg cagataaagt
      481 atggaggttg gacctcgtca tggtgatctt gttcaaaggt attccgctgg aaagtactga
      541 tggtgaacgc cttgtgaagt ccccacagtg ctcgaatcca gggctctgtg tccagcccca
      601 tcacataggg gtttctgtaa aggaactcga tttatatttg gcatactttg tacatgcagc
      661 agattcaagt caatctgaaa gtcccagcca accaagtgat gctgacatta aggaccagcc
      721 agaaaatgga catttgggct tccaggacag cttcgtcaca tcaggtgttt tcagtgtgac
      781 tgagctagta agagtgtcac aaacaccaat agctgcagga accggcccca atttttctct
      841 ctctgatttg gaaagttcct catactacag catgagtcca ggagcaatga ggaggtctct
      901 acccagcaca tcctctacca gctctaccaa gcgcctcaag tctgtggagg acgaaatgga
      961 cagtcctggt gaagaaccat tttacacagg ccaagggcgc tccccaggga gtggcagcca
     1021 gtccagcgga tggcatgaag tagagccagg catgccatct ccaaccactc tgaagaagtc
     1081 tgagaagtct ggtttcagca gcccctcccc ttcgcagacc tcctccctcg gaacagcatt
     1141 cacacagcat caccgacctg tcataacagg accgagagca agcccacatg cgacgccatc
     1201 gactctccac tttccaacgt cacctatcat ccagcagcct gggccttatt tctcacaccc
     1261 agccatccgt taccaccctc aggagacgct gaaggagttt gtccaacttg tctgccccga
     1321 tgctggtcag caagctggac aggtggggtt cctcaatccc aatggaagca gtcaaggcaa
     1381 ggtgcacaac ccattcctcc ccaccccaat gttgccgccg ccaccgccac caccgatggc
     1441 caggcctgtg cctctgccca tgccagacac caagcctcca accacatcaa cagaaggcgg
     1501 tgcagcctcc cccacctcac cgacctactc gacacccagc acctcccccg caaaccgatt
     1561 cgtcagtgtt ggaccacggg atccaagctt tgtaaatatc cctcaacaga cacagtcctg
     1621 gtacctggga taaaagttgc agcgtcccac catcctccag acagaccacc tgaccccttc
     1681 tcaactctgt aacatggacg caacctcaac ccggcgcagt tacaacttca ctgtcagtgg
     1741 aaggggagag acaccaactc gaatcaactt gtacatggaa acagcgaacg tcgtggtcaa
     1801 acagcaaagg ccataacttt tcgggattct tttttttttt ttaatacttt agggactgtc
     1861 gtaatttctc atatggtgct ggaaatggtt gggctgtgtg acatttgaag tgttccagtg
     1921 gtggtgtgag cagtaggtga agcggctggt aggggatgag ccttgctcac gaacttcctg
     1981 ttgtaacact tgtgagcctg gccttttcac agtatttcaa gaatttgccc gcgcaggtgt
     2041 gtgaccctcc cggagcactt ggagacacct ggagaatgaa atctttcgta gtagctaaga
     2101 tctgtgatct gtaacttaca ggacactcaa agggcaatgt tttttgggtt ttcttttttt
     2161 tctgtaacat attagaaaaa gcaaatgcag ttaagttgat ctttctttta gtttggtttg
     2221 gttcagcagt cagcagttaa atacataaca caaccctcaa ggacagtgaa cccactcatg
     2281 ttgcagagca aatccaaaaa gacagcaaag actactacta ctactctcag ttcggttgtt
     2341 tgtttttttg ttttgttttg tttttttatt aagttttgaa atgctgcact tacatttaaa
     2401 aaaaaacatt tttcaacaat ttcaacaatg acacaaaagt tcacatggaa atggggaaga
     2461 tggtctgttt tgacagaaac tgacaggaat caaaacaatc gaattttgaa ttgagtgaag
     2521 tgcaatttca ttggatagct aagtatcttt gtaagataga gattgttgaa aattctattt
     2581 ttgtttttca agtcctccca ccccaggact ctaaattatt ggggttaaaa aaaaacagcc
     2641 ttgcaagaaa aaggggagct atttttgctt tttatgtttt ttattgttaa acttgtatcc
     2701 ctttaaaaaa aaaaaaccga aggaaaattt aaaaaaaaaa acaaaaaaaa aaatacaaat
     2761 ctaatggtgc ttttaccaca atatgttaac tacattaaat gctaattaat tattttctgt
     2821 tatcaaagca cataactcaa atgaaatcat ggtatctgtt aattttataa gctagaaatc
     2881 actataatga attatgccaa ttctggaaaa ttttacacat gtatggcaac accagatcta
     2941 tcggttttca aacgcctcgt cgtaaccaga cattgtccag aagtttcaaa gacccttcgc
     3001 aaaccctgaa ctgggctacg gggaaataat actaacactg ataaggacat aactgtgtga
     3061 gcccattcag atcaaagtac ttgttaggga aaataaacaa acaaacaaaa acaaaatgtt
     3121 cacacacaca cacaccccca aatgtcttgt atcttatgtt taaggaaaaa agaaaagaca
     3181 aaaaaaaaga caaaaaaaaa tcaaaacaga aaaaaaagca gaaacaaata aataaacaaa
     3241 aaaaaatgca agtgattttt ctaccagaca gcgaagcacc cccttgcttc ccatgcgact
     3301 tcacggtttc ctatactata cgtatatatg tgttctggtc ggcaggccct gcccaccaga
     3361 ggaagtctct gcatgttcta gtgttagtaa ctaattttta tatagctaat gtaggataaa
     3421 gtagagtgca ttaagacaat attgtaaccc cagtctaggc acttgccttt aaactgtctc
     3481 agcccttcag aagggctcaa ctactgtcct atacaatcaa gtgactgaaa ctcctgggaa
     3541 gacactttgc tcctcatcta accccccccc caaaaaaacg atgttgtttt gtttttattt
     3601 ttttccttaa tttgcacgaa aacagaaatt ccatatcaat gtgccttgcc ctggatagtg
     3661 atttttttgt ggaattgttg cacatgctcc tcaattgaag gggtttaatc cctactcaag
     3721 cattcggaga cactttttgt aaatgtaact tttatgtcag ccatcgtcag tttccacatc
     3781 tagacctaaa tagagaggta gctgttacgc agacaggcgt agtctcggtt gtcctgtgtg
     3841 gtcagtggca gtgctattct gagctctgta gatgcttaca acgtcagtat ttggatgtcg
     3901 ctgcattttt ttttttcaat ttctttggag tcttcctttg tccccgcccc caccccaccc
     3961 cccccagata tatgaaaata tgcaatacct gcttatatca tgtagaaaag cttagcaagt
     4021 attaattttt ctttctttct ttttttttat ttgaccaaag tcagtgctgc acatgacgca
     4081 gtgggtttta ggtgtctgtc tttgtgtttt ctgtggtttc tgatgcacgt gtgcaggaag
     4141 ggctcctctt agagaagcag tcaaactgtg aagcactaag ctgaccctgc ttcaagcaat
     4201 tttgttttta caactgttcc tttcacaagc aagccttaaa aaaaaaaaac aaaaaacaaa
     4261 aaaaaacaaa aaacaaaaaa agacaacttc ctttctcttc agcccccaca cccacttttc
     4321 ttagcagacg gcagtcaatc cacattcaat aagaaataca taatgcccat ttttatatgc
     4381 acgtttttaa acttccaagt tctgaaaatt gtttactggt tatctctatt taaggaaaaa
     4441 aaataaaata aaacattttg gattttcata tgtgtctgat aagtggttgt atagtcgttt
     4501 ggcgctgttg tacggtgtga ttatcagtgt acggtgtcac ttccgatagc cagcagcaga
     4561 ctttgccttc cctatagcac ttagctgggc attactttat tatgacatat gtgcactaaa
     4621 agagagagag agagagagag agagagagag agagagagag agagagagag agaaacatag
     4681 cagctttcag tgcttcacgg tgaagggaaa aaaaagccta gacaaacatt ttgtcagaac
     4741 cttgcaaaat gccaaggtat taccagtaaa ttggttgtat atacaataaa attgcaccct
     4801 ttttttaaac aaaacgaact aagcaatagt ttgggcagtc ctagttgttt ttagcgagca
     4861 tgttgtagtc ttgactgcaa agagagagaa taagctgccc actcagaaga tatgtaattt
     4921 gtatcgttgt atagttttat tgattacact gatttattct accctatttt ataatgcagg
     4981 acttttgtaa tgttgtctaa atgaggaaaa aaaatctctg tcaaattagc ctagtgaaat
     5041 ttccgattgt ccattaccaa ggcaccgttc atagcattga tccttctttc ttttcctcct
     5101 cctttggaaa ctggattaag tttaaaactt tcccgtttcc tttttatttg gttgtgttgg
     5161 gttggttttt tttttaagta tttaaatgca attatttttt tctgccaatg gtatcacata
     5221 ttcctatgct tgagaagtgt aggtctactg aaaaaccatt gcaagtggac gttccaggtg
     5281 tgctgtactt ttgaaggtat tttgttgtat taggtttaaa agtagggaac tctgaacaga
     5341 tttgcaggaa caaaagatgt ttcaaaaggc tctcgaccat tgtggaggca gcgtggggta
     5401 acagcaaaca agggttaagt agaaaataca ctgagttctg ttctgttcat gcttcattgt
     5461 caagacagca gcagaaaact gtatggagtt ctgttgtcat cgagcaggaa acaagggatc
     5521 accgaccaat gcattttagg ttaagagctg agccaaggtg tttgaggaag actttcctac
     5581 aggagtgtag agacagacag tcccaagagc tatcaacatt tgaaggccca gacttgattc
     5641 tgagacatgt tggatttttt ttcccctctc ccatcaaatg gcatcaacac aattagcaaa
     5701 gatagtccct caaatgactc cttccccccc catttttgtc tttgggaact gaagtcagag
     5761 gcacaaagac taactttcag cattttccaa taaatgttct cccttggccc ctctcctggc
     5821 caccacaaaa ctcctttttc taaactgtcc tgagcagaag tcttctctgg tgccattgtc
     5881 ctggtcctcc agcccttctc tcccctctaa ggttatgtct cttcactgcc tggcatgaca
     5941 tctataagct cactccccat acagggccac caccacccac atggactccc actggccctc
     6001 tgggctcaat tctccaagct tcccttctcc tttcccggca gtccaagagt gcaggatcca
     6061 aatttctagt cacgctgtgc tatattcagt cagcccacaa gaatatgcaa actccatctc
     6121 aaaaatattg tctttcacct tcccaaatct ttatcctcgt gtgcttcaac ctctgtagag
     6181 caatatcatg aggtagttgc aaaggaaaac attttctctc atgatttact ttttgttgtt
     6241 gttattgttg ttgggttgga ggggttttct ttgtttgttt ttctttcttt gggttttgtt
     6301 tttgtttttg atggggtatg gtctttaaga ctgtcatttg acatttttac atcagatccc
     6361 atagtccctg tctcttcctc cttccctccc tgtctccttc tctgtttctt tctgtctgtg
     6421 tatgtctctc tggttcttct ttgcttcttt tccccttctg gtttctggta gcaggcctcc
     6481 attgaactgt tgtaaaacac aagaagtgtg gtcagtagga gagttttggt ggtgcctccc
     6541 agcctactgg ccaaaccatc ctagacactc ccagaggctg ctccattctt gggcatggct
     6601 ttcatttaca tgggctttgg aggccatttt gtcttgaagt caatgcatgc tctcatgctg
     6661 ttcgacagta acctactctg ccttctccac gtccaaggct gtgcatttgt ccaattagtg
     6721 tcatgaatgt ttccccttta ttttttccaa taaaaaaagc agtgggatga aaattgcttt
     6781 gatatatagc aggaatattg aagctattcc atagcactta accgtagtga atactgtgtc
     6841 cccagttctg aaatcaattt aatgtttaat gcaaatccat tacatggtgc tattacaggc
     6901 tgacaaaatg atttacacaa atgtgacaac tcgggctcag ttcactctgc ttcccaacag
     6961 tgtaaatgca tagcagtgtt tatctgcatg agaactatgc actaatctat ctgaagaaaa
     7021 aaaaaaacta tatcaacttt ggtatctact ttccgtttac ttcaatcctt gcctttttgg
     7081 tcattgttat aatgccagct ttaggacaga aagaattata agaaaaccag cataatacct
     7141 gatatattaa aatgtagtgc ctgtgaaacc tgtattatac tgctcttctg aagtaagatt
     7201 tttctacacc ggtagccttc gctgtctgtc agtcaggacc tctggtatag gtgatgtaaa
     7261 ataaccgtac aatattatgc atgctatccc ataatgctta gtgactgtat gatattactc
     7321 agagttctgt tagacttttt tttctgcctc agttcttatc agctaggttt gaggtatttc
     7381 actgagaacg tgaactcggt cttccttctg gctgtcttca tgatcttgga ggtgtacact
     7441 tacttaaatt cagtattact tgtgtttgtt ttcatttttg tttttttttt ttttttgctt
     7501 tgttttgttt tgtttctcct aagggacaag catgggtgtt tgatttcaga aatcagtata
     7561 tggtgagatt tttgtctcaa aactaccatt tgaatttcaa gaactctgct gcaaaaacca
     7621 gtctgagaat gtttccaagt gagagtcact ttgctggccc tcgacagaag ctagacgaca
     7681 ctgaagaacc ttgaaggaca gtgtacccat gcttgatcag cctcactcca gacttcctca
     7741 tagtaaaaag gaaaaaacaa aaaaatttac aaaatcacgt agctatttag ttacatgcac
     7801 agatgcaata ttttcttcaa aaatataact ctgtacaaac ttcgggcccg attcataaga
     7861 aagaagtttg ctattaacac gggattttta aaatatgttc tctctctctc tctctctctc
     7921 tctctctctc tctctctctc tctctcaatt taaatttgaa actgtttgct tcccaatttg
     7981 aatatttttc tttaatttcc cccgaaccag cacccatctg cctttcattc tccaaagggt
     8041 tgcattaagg aagttggagg gatactatat ggggactgga tcccagtgac gaggctaagt
     8101 gggaactgta gggtaggaat ataacacatg gatgcacccc ctctgtgtgt caggcatcct
     8161 acatgtagac tcactgtgct gtttgggctg aaacattaac tttgtaaaat gtgtctggac
     8221 cacaagagta tataggagaa gtgctacctc cgatctaact agagcaagtt catggcagaa
     8281 agtatcacat actttaaaaa tgtgaagttt cccgtctctc cagtggtttc caaggcaagt
     8341 ggtgtccaag acacagaccg ttttcatgtt gttcaatgct cggctttgta aaaagcccaa
     8401 agctatcttc tctcggcttt gactgctaat tgtattgctc ttggttgttt ttatttttaa
     8461 atttttttct tggtaatggt ctgtaaattt gctttttttt tttaacctat tattccccac
     8521 taaaggtctt aggcatctgg ccatgtcagg atgcagtgag ggagccgcca gctttcttct
     8581 ccctcagacc attgtctctc cactgaacta ggctgcctcc ctaccgaggt gccagccaga
     8641 ggagtgccag caagtcccag taggtcctta ggaaggctcc caaggccaag tccgtggttc
     8701 cttctctgct tctcccacat acctttccca tcacacacgt caaacatctg ctcagagtgc
     8761 ctctgttctc ttttcaaatt gggggggggg attaaaaact tcaaatgatg gaaaaaacga
     8821 gatctcttgt gaaatggaac gccccgtgtt aataacttgg tctgaaattg tttttatgag
     8881 ccgggccccc tgtgcctcta gcatatttgt actgactctc atagttaccc ttttcgttta
     8941 ctgtgttctg tgaaaacttg taattggttg agaatcactg tgggcgtcca ttcttatcaa
     9001 ctaagtctcc acagggtttt tgagctggtg tggattagtt taactcttgt attcaaccgt
     9061 tagtgctacc accttctcac atcacaatac aattactgga agcaagtact gcatttccta
     9121 tgcaacagaa aaggaaaaaa taaaacaaat tgctaatgct a
//
LOCUS       NM_001436576            2559 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus transcription factor Dp-1 (Tfdp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001436576 XM_039094676
VERSION     NM_001436576.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Okuda,M., Araki,K., Ohtani,K. and Nishimura,Y.
  TITLE     The Interaction Mode of the Acidic Region of the Cell Cycle
            Transcription Factor DP1 with TFIIH
  JOURNAL   J Mol Biol 428 (24 Pt B), 4993-5006 (2016)
   PUBMED   27825926
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Gong,W., Gohla,R.M., Bowlin,K.M., Koyano-Nakagawa,N., Garry,D.J.
            and Shi,X.
  TITLE     Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates
            Skeletal Muscle Myogenesis through the E2F1-DP1 Complex
  JOURNAL   J Biol Chem 290 (24), 15350-15361 (2015)
   PUBMED   25940086
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_039094676.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.47643.1,
                                           SRR26643291.38606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000016.1  82902867-82902983   c
            118-192             JAXUCZ010000016.1  82902097-82902171   c
            193-259             JAXUCZ010000016.1  82885930-82885996   c
            260-366             JAXUCZ010000016.1  82877461-82877567   c
            367-488             JAXUCZ010000016.1  82872461-82872582   c
            489-798             JAXUCZ010000016.1  82871245-82871554   c
            799-867             JAXUCZ010000016.1  82870780-82870848   c
            868-1019            JAXUCZ010000016.1  82869556-82869707   c
            1020-1186           JAXUCZ010000016.1  82869032-82869198   c
            1187-1265           JAXUCZ010000016.1  82868362-82868440   c
            1266-2559           JAXUCZ010000016.1  82864220-82865513   c
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2559
                     /gene="Tfdp1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
     exon            1..117
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..192
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    160..162
                     /gene="Tfdp1"
                     /note="upstream in-frame stop codon"
     CDS             181..1413
                     /gene="Tfdp1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transcription factor Dp-1 isoform 1"
                     /protein_id="NP_001423505.1"
                     /db_xref="GeneID:361178"
                     /db_xref="RGD:1560344"
                     /translation="MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGK
                     QLLPKTFGQSNVNITQQVVIGTPQRPAAANTIVVGSPHTPNTHFVSQNQTSDSSPWSA
                     GKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAY
                     DQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQ
                     KQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSI
                     SNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKVARSLVPKALEPYV
                     TEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSY
                     VGEDDDDDDDFNENDEED"
     misc_feature    514..759
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    514..759
                     /gene="Tfdp1"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     Region: E2F_TDP; pfam02319"
                     /db_xref="CDD:460530"
     misc_feature    order(772..774,784..786,793..798,802..807,814..819,
                     823..828,835..840,847..849,856..861,868..870,877..882,
                     886..891,895..903,910..912,943..978,982..984,1015..1041,
                     1045..1047,1051..1053,1057..1059,1075..1080,1084..1086)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    order(772..774,784..786,793..798,802..807,814..819,
                     823..828,835..840,847..849,856..861,868..870,877..882,
                     886..891,895..903,910..912,943..978,982..984,1015..1041,
                     1045..1047,1051..1053,1057..1059,1075..1080,1084..1086)
                     /gene="Tfdp1"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271217"
     misc_feature    772..912
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    772..912
                     /gene="Tfdp1"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:271217"
     misc_feature    778..1194
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    778..1194
                     /gene="Tfdp1"
                     /note="Transcription factor DP; Region: DP; pfam08781"
                     /db_xref="CDD:462601"
     misc_feature    order(844..846,853..858,865..867,964..966,991..993,
                     997..999,1042..1065,1084..1086)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     misc_feature    order(844..846,853..858,865..867,964..966,991..993,
                     997..999,1042..1065,1084..1086)
                     /gene="Tfdp1"
                     /note="RbC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:271217"
     exon            193..259
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..366
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..488
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..798
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..867
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1019
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1186
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1265
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2559
                     /gene="Tfdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtgagcc cgcgtcccgg cgccgctggc tcagggcagg gaccgccagg gccggacctc
       61 cgggccggcg cccccgcgcc cccgtcgtcc gccccgcgcg ccccgccggc cagccagata
      121 agtccggttt cttctgtgga gggtacgcag ttaaagcctt gatttcctgg atctggtaac
      181 atggcaaaag atgccagtct aattgaagcc aacggagaac taaaggtctt tatagaccag
      241 aatcttagtc ctgggaaagg tgtggtgtct cttgtggctg tgcacccatc cacagtgaac
      301 acactgggga agcagctttt gccaaaaacc ttcggacagt ccaatgtcaa tatcacacag
      361 caagtggtga ttggcacgcc tcagagacct gcagcagcca acactattgt ggtaggaagc
      421 ccacacactc ccaacactca ctttgtgtcc cagaaccaga cgtctgactc ctcaccttgg
      481 tctgctggga agcggaacag gaaaggtgag aagaatggca aaggcctgcg gcatttctcc
      541 atgaaggtgt gtgagaaggt gcagaggaaa gggacgacct cctacaatga ggtggccgac
      601 gagctggttg ccgagttcag cgccgctgac aaccacatct tacccaacga gtccgcctac
      661 gaccagaaga acatccggcg gcgtgtgtac gatgccttaa atgtgctgat ggccatgaac
      721 atcatctcca aggagaagaa ggagatcaag tggatcggcc tgcccaccaa ctctgctcag
      781 gagtgccaga acttagaggt agagaggcag cggaggctgg agaggatcaa acaaaagcag
      841 tcacagctcc aggagctcat cctgcagcaa attgccttca agaacttggt gcagagaaat
      901 cgccaagcgg agcagcaggc ccgcaggcca ccgcctccca actctgtcat ccacttgccc
      961 ttcatcattg tcaacaccag caggaagaca gtcatcgact gcagcatctc caatgacaaa
     1021 tttgagtatc tgttcaactt tgacaacacg tttgaaatcc acgatgatat cgaggtgctc
     1081 aagcgcatgg gcatggcctg tgggctggag tcgggcagct gctctgctga agacctcaag
     1141 gtggcgagaa gtctggtacc aaaagctcta gaaccgtatg tgacagagat ggctcaggga
     1201 tccattggcg gagtatttgt cacgacaaca ggttctacat ccaatggcac aaggctttct
     1261 gccagtgatt tgagcaatgg tgcagatggg atgctggcca cgagctccaa tgggtctcag
     1321 tacagcggct ccagggtgga gacccctgtg tcctacgttg gggaggatga cgacgacgac
     1381 gatgacttta atgagaacga cgaggaggat tgattactca actgtagacc cttctcccct
     1441 cagtcagctt caggaaaaac gtatagagaa aagaagcttt tgaagtgggg ctttccgttc
     1501 tttctggcct actcccaaga agatgccgcc gagttgtgga gttagatatg cagctccaag
     1561 taaggagtgt gcccgcggtg tgagcgagct gtggatgtgt cgtgaagcca gcgtgctaga
     1621 gcagagcctg tatctacctt ttaggatttt atggttcctc tttctttctt ttttttgttt
     1681 atcttctttc ctttcttttt taagtttgaa gcttgttttg cccctcaaca gttgttgctg
     1741 gtttgctgag gaggctgtgc tgcgccccca ccggtgacag tggtaaagcg ctgcccgcct
     1801 cgggtgtgcg gcgcccaggt ggtggacagc caggcgttag gatggatttt cccatttgtc
     1861 aaatcatgca gagtccagag aacaaggcga tagcaaagct ccactgttaa cgctgcgcgc
     1921 catacgtctc atgactgttt ttccttaaat tatactgact gtccagttcc atcaatcaac
     1981 cttttctcaa gcagcagcaa agcgagaagt agtgtttctt gtttgtttgt tttgttttgt
     2041 ttggaagaag tttactgcca cgctggcgca gctatggaaa ttgtctagaa agtttgctta
     2101 tggtaaattt gcctgatttc ttacaggcta cgtttggaaa ctttttatta tatagtttac
     2161 atacttataa gtctatcatt taaagacgtg tactgaaaca aatgttgtat ttgtttcata
     2221 agcatcttcc tgtaatctat tataaaattg aaattaaaca tagagaatgt tttaacagtt
     2281 ttttaactca aaatttgtca atcattttta atagttcttt ttttataaaa agaaaaagga
     2341 atttaaggac aggcaatagt ctcttaaaat ttattcacaa gaaccgttaa ctgcacagct
     2401 gcccttagct gcctgttcta aatgatggtc tttttattga aacacaaata aacttttctg
     2461 taatatttta tggaatataa agagacttta attgtttgac ctgtttaact aagcactgtt
     2521 agtttttatt aataaaacgc gcatgggcat tttaaacaa
//
LOCUS       NM_001436568            1403 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus glutamate-rich 1 (Erich1), transcript variant 1,
            mRNA.
ACCESSION   NM_001436568 XM_006253395
VERSION     NM_001436568.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1403)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253395.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227386.1, BC167071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  82203615-82203692
            79-225              JAXUCZ010000016.1  82217914-82218060
            226-360             JAXUCZ010000016.1  82234137-82234271
            361-789             JAXUCZ010000016.1  82264721-82265149
            790-981             JAXUCZ010000016.1  82268071-82268262
            982-1403            JAXUCZ010000016.1  82270940-82271361
FEATURES             Location/Qualifiers
     source          1..1403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1403
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="glutamate-rich 1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
     exon            1..78
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1055
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="glutamate-rich protein 1 isoform 1"
                     /protein_id="NP_001423497.1"
                     /db_xref="GeneID:306622"
                     /db_xref="RGD:1559872"
                     /translation="MSSLRKQVFTEKVLKRLFPNVSSGQEKGTPQTPALDTPSKDSTP
                     EAVQQKPVRGLTAGDIKIQPERRLYTVSLPPPGYIPCLPEPTSCADSENASSGGDTED
                     PGLPDQPKRRRIRRHKSKKSIKSLGGVTVRQTELETQREKTHPPHPDAPAMSRNKKRK
                     WRAKLRLRRKREAGLAARASAASFTYEPESSEEAEVEGDVGGEEEEDPESSVADPAQE
                     DTELASSRADSLLSFLKSTQEIYFYDEASREDPAVSTEAAEELLRLLESGRLPPADVL
                     ILDHMKTLLLLQDTERLTSALKMFPEHCMMPPDHARIISAFFNYWITQILPEKRSE"
     misc_feature    <687..>1001
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     misc_feature    <687..>1001
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /note="Nuclear condensing complex subunits, C-term domain;
                     Region: Cnd3; pfam12719"
                     /db_xref="CDD:463678"
     exon            79..225
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            226..360
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            361..789
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            790..981
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1403
                     /gene="Erich1"
                     /gene_synonym="RGD1559872"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcgccg cgcgactggc ggcggctggg gccggagatc ccggccggga tccagtatgt
       61 cttctcttcg gaagcaggtg tttactgaga aagtgctgaa gagacttttc cctaacgtct
      121 caagtggtca agaaaagggc actccccaga ctccagcttt ggacacacca tccaaggact
      181 cgacccctga agcggtacag cagaagcccg ttcgtggtct gacagctggt gacattaaga
      241 tccaacctga gcgtcgcctc tacaccgtga gtctgcctcc tccagggtat atcccttgtt
      301 tgccagaacc gaccagctgt gcagattccg aaaacgcctc cagcggtggt gacacagaag
      361 acccgggtct tcctgaccag ccgaaacgac gaagaattag acgacacaag tcaaagaaga
      421 gtattaaaag cctcggtggt gttaccgtaa ggcaaacgga actagagaca cagcgagaga
      481 aaacgcaccc gccacatcca gatgcccccg ccatgagcag aaataagaaa aggaagtgga
      541 gggcaaagct gaggctgagg aggaagagag aagccggctt agccgccagg gcctctgcgg
      601 ccagcttcac ctacgagccc gagagcagcg aggaggcaga ggtggagggc gatgtgggag
      661 gagaggaaga agaggatccc gagagctcag ttgcagaccc cgcccaggaa gacactgagc
      721 tcgccagcag cagggcggac agcctcctga gttttctgaa gtcaacacaa gaaatctact
      781 tctacgatga agcttccaga gaggacccag ctgtgagcac agaagctgct gaagagctgc
      841 ttcgcctcct tgagtctgga cgcttgcctc ccgcagacgt gctcatcctg gaccacatga
      901 aaaccctgct gcttctgcag gacaccgaga gactgacgag cgccctgaag atgttccccg
      961 agcactgcat gatgcctcca gaccatgcca gaataatctc ggctttcttt aattattgga
     1021 tcacgcagat tcttcctgaa aaacgcagtg aataaatcat tgtcacctga gaagagctgt
     1081 catttaacac ggagttatta ggtgcgcata ggatgcgaac tgagactcca cgattgcaca
     1141 taaagagtta tttattattt ttattttcgg cgaatcaaac cctggagaca ttgaagacat
     1201 ttctaccctg ttatttattt ccgtgtttgt atgtcatagg taaggtatcc tctgagactt
     1261 taagtgagaa actggggtaa aatgagagca tttacttgct taccgttaca cgtacattga
     1321 tttacttcat aaaactagat tgtcttttga tgcctgtaac agaaatagat attttattaa
     1381 ataaactata tagtttgaag tta
//
LOCUS       NM_001436583            2926 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), transcript variant
            1, mRNA.
ACCESSION   NM_001436583 XM_006253465
VERSION     NM_001436583.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253465.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.633681.1,
                                           SRR26643293.76037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000016.1  84706044-84706216   c
            174-324             JAXUCZ010000016.1  84699112-84699262   c
            325-370             JAXUCZ010000016.1  84698119-84698164   c
            371-459             JAXUCZ010000016.1  84697425-84697513   c
            460-568             JAXUCZ010000016.1  84696157-84696265   c
            569-619             JAXUCZ010000016.1  84693098-84693148   c
            620-724             JAXUCZ010000016.1  84692913-84693017   c
            725-845             JAXUCZ010000016.1  84692286-84692406   c
            846-966             JAXUCZ010000016.1  84691110-84691230   c
            967-2926            JAXUCZ010000016.1  84688239-84690198   c
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2926
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..173
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1117
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /EC_number="4.2.1.93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carbohydrate kinase domain containing; ATP-dependent
                     NAD(P)HX dehydratase; carbohydrate kinase
                     domain-containing protein; ATP-dependent
                     (S)-NAD(P)H-hydrate dehydratase"
                     /codon_start=1
                     /product="ATP-dependent (S)-NAD(P)H-hydrate dehydratase
                     isoform 1"
                     /protein_id="NP_001423512.1"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
                     /translation="MGIRCVAIRACGGGKIDTGVPRMAVCPYGAAAVVMALLSAAIAF
                     HCSPLLAVLQRALSLHTAHATKDMDNLFQLVRNIVPALTSKKHKGQDGRIGIVGGCQE
                     YTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPELIVHPVLDSSDAVEEVEKWL
                     PRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVIDADGLWLIAQRPALVHGYQK
                     AVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQALGNITIVQKGEQDLISNGQQV
                     LVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKTNGSSPLLVAAWGACTLTREC
                     NHLAFQKYGRSTTTTDMIAEVGAAFSKLFTT"
     misc_feature    278..1081
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="B.subtilis YXKO protein of unknown function and
                     related proteins. Based on the conservation of the ATP
                     binding site, the substrate binding site and the
                     Mg2+binding site and structural homology this group is a
                     member of the ribokinase-like superfamily; Region:
                     YXKO-related; cd01171"
                     /db_xref="CDD:238576"
     misc_feature    278..1081
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="B.subtilis YXKO protein of unknown function and
                     related proteins. Based on the conservation of the ATP
                     binding site, the substrate binding site and the
                     Mg2+binding site and structural homology this group is a
                     member of the ribokinase-like superfamily; Region:
                     YXKO-related; cd01171"
                     /db_xref="CDD:238576"
     misc_feature    order(344..346,887..889,896..898)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:238576"
     misc_feature    order(344..346,887..889,896..898)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative substrate binding site [chemical binding];
                     other site"
                     /db_xref="CDD:238576"
     misc_feature    order(689..691,809..811,890..895,902..904,1013..1015)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238576"
     misc_feature    order(689..691,809..811,890..895,902..904,1013..1015)
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238576"
     exon            174..324
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            325..370
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            371..459
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            460..568
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            569..619
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            620..724
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            725..845
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            846..966
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2926
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtccgc tggacggtca tgggcatccg gtgtgtggcg atccgcgcct gcggaggagg
       61 taagatcgat accggcgtcc cgcggatggc tgtttgtccg tatggggctg cggcggtcgt
      121 gatggcactg ctctccgccg cgatcgcgtt ccactgttcg ccgctgctag cagttttaca
      181 aagagcactg tccctccaca cagcgcacgc aacaaaggac atggacaacc tttttcagtt
      241 ggtgaggaac attgtgcctg ctctgacgtc gaagaaacac aaggggcaag atggaaggat
      301 aggcatagtc gggggctgtc aagagtacac aggagcaccg tattttgcag gaatctcagc
      361 tctgaaagtg ggtgcagatt tgacccacgt attctgtgcc agggaggccg cgccagtgat
      421 caagtcctac agcccagagc tgatcgtcca ccccgtcctt gacagttctg acgctgttga
      481 ggaggtggag aaatggctcc ccaggctgca tgcccttgtc gtgggacctg gcctaggtag
      541 ggacgacctt cttctcaaca acgtgagggg catcttggaa tcaaccaagg ccagggacat
      601 ccctgtcgtc attgacgcgg acggcctgtg gctgattgct cagcggccag ccctcgtcca
      661 cggctaccag aaggccgttc tcacccccaa ccatgtggag ttcagcagac tctgggacgc
      721 tgtgctcagt agtcctatgg acaccagtaa tcacagtgga tctgtgttga agctcagcca
      781 ggccctgggg aacatcacca tagtccagaa aggagagcag gacctgatct ccaacggcca
      841 gcaggtgctt gtgtgcaacc aggaaggcag cagtcgccgg tgtggtgggc aaggagatct
      901 cctgtcaggc tccctgggtg tcatggcaca ctgggccctc cgtgctggac cagagaaaac
      961 caacggctcc agcccgctcc tggtggctgc ctggggtgcg tgcacactca caagggagtg
     1021 taaccatctg gccttccaga agtacgggcg ttccacaacc actaccgaca tgatcgctga
     1081 ggtgggagct gccttcagca agctcttcac gacctgagcc ggcacagact gagtcctcca
     1141 tcgcctagcc ttgggctcag cagcacttga tggattttag cctgaagtag ctgacaggat
     1201 ttaggacgtg gctgtccgac tactgtagag ttgagatgtt aaggacacta atctggtctc
     1261 cgtggttttc tgggcttctc agaaaagtct gaggagaaaa tgagagtaaa ccctcccagc
     1321 agcccacctg gattgggctg gctctgacac agacatttgg agtccatggc tgttcattca
     1381 ttgattctgg tgcctttttg tcactacagt aaccacgcac agggctccag tctctgggtg
     1441 gtgggggagc gcagggtttg tttcctaacc aaggctcaca ggatggcatt cttgggcctt
     1501 acagttttct attcagtgac tgagtgttaa cttcgagagg agttcagaag agacagtggc
     1561 catgcagagg agatctttta gcggccagtg ggaagggcag gaaaccaggg tgccactggc
     1621 atttgagcgt ggcagggagt gccaagatgc cacgtctgct acctgtgttc actgctgtgt
     1681 actgggccct gcgctccctg ccgagcctcc ctccaggctc cctgacagct gcatgcctag
     1741 tgagtagggg tctgctctct ggctcccctt gtgtctggtc cttggtcaca agggacagct
     1801 aaccatgtcc aggaatgtct cctgaacaga catgaactta ctgaagggaa tggtacgacg
     1861 caattaactt tccaggctgt tccgaacaca caccagtggg cagcacaggc tcactttact
     1921 gtggctaaac agccacaatt agcaacttta atataaagtt tttaatacaa agttcaccac
     1981 aaagaaagca gatgccatgc gtggaggcac gtggactgca gctgcctcat cctcaagtcc
     2041 cgggcttctg gtgttttgtc ctcggatcca gcagttccca tgtggaggct gcatggcctc
     2101 tgtcctgaag gagaaagctc tggatagcat cacatcctct tgttcatggt cagagagcaa
     2161 aggcagagag aggaggcgga ggagaggggg gtgacactgc ctgacagggc cagctcctcg
     2221 accacgaggg ttgagttttg cagctcttgc tgctacacat cttcccctca gccctccacc
     2281 cctgccttga gtgggcctgt ctcagacact ggatgaccag ccactgtccg cccctttact
     2341 gcctgcgaca ttggcagccc ctgtacctgc agtgtcactc accttaacat tgatgccgtg
     2401 ggtcatgagg tcctggcgga gtgcgtcaca tgcctccagc aagggctgcc tctcctggag
     2461 ctgctgtttc cgggcctccc cggtggcccc aggcgtggcc agtgcatact ggcggacctt
     2521 aagcctgaag cgcactagtt catctaccac acagtgcagg gctactgtgc tgctgtctcc
     2581 tgaaacacac tgagccatag actcttagat gagtctgccc cgcaaggcag gagccccggt
     2641 atagcctggg agaccatact cgactacatt ctgggctgag acctgaagtc cttactagtt
     2701 aatcctgatg agccctttct ggagaatatg aggggaggtt aggttagtaa gaccagctca
     2761 gcaagacttc atgcctgact ggctcactta agctgaccct gacccaccac cagacctcag
     2821 caacagttgt agggtgtgac aagtgtcaac agaatcctgt catctccaga gaatctagca
     2881 gcctgagcct taagtgtgaa taaagacaaa catttctgcc atagaa
//
LOCUS       NM_001436582            1827 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Rattus norvegicus cysteinyl-tRNA synthetase 2, mitochondrial
            (Cars2), transcript variant 2, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001436582 XM_006253462
VERSION     NM_001436582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253462.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.59657.1,
                                           SRR26643298.72345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000016.1  84652088-84652321
            235-285             JAXUCZ010000016.1  84652506-84652556
            286-403             JAXUCZ010000016.1  84654131-84654248
            404-475             JAXUCZ010000016.1  84660918-84660989
            476-581             JAXUCZ010000016.1  84661472-84661577
            582-665             JAXUCZ010000016.1  84666898-84666981
            666-795             JAXUCZ010000016.1  84672846-84672975
            796-929             JAXUCZ010000016.1  84673517-84673650
            930-997             JAXUCZ010000016.1  84677454-84677521
            998-1064            JAXUCZ010000016.1  84684762-84684828
            1065-1203           JAXUCZ010000016.1  84685053-84685191
            1204-1327           JAXUCZ010000016.1  84685714-84685837
            1328-1426           JAXUCZ010000016.1  84687155-84687253
            1427-1633           JAXUCZ010000016.1  84688576-84688782
            1634-1827           JAXUCZ010000016.1  84689061-84689254
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1827
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:361184"
                     /db_xref="RGD:1311612"
     exon            1..234
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1705
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /EC_number="6.1.1.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable cysteine--tRNA ligase, mitochondrial"
                     /codon_start=1
                     /product="probable cysteine--tRNA ligase, mitochondrial
                     isoform 2"
                     /protein_id="NP_001423511.1"
                     /db_xref="GeneID:361184"
                     /db_xref="RGD:1311612"
                     /translation="MLRALRPGPGAPLLRAALVLGRRGRAWQRPQGQDTGVQVHNSLT
                     GKKEPLIVGRSDAVSWYSCGPTVYDHAHLGHACSYVRFDIIRRILTSVFGCNVVMAMS
                     ITDVDDKIIKRANEMNVSPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIISF
                     IQGIIAHGHAYATATGSVYFDLRARGDKYGKLVNTVPSATAEPVDSDKRHSSDFALWK
                     GAKPQEVFWASPWGDGRPGWHIECSAMASEVFGSQLDIHTGGIDLAFPHHENEIAQSE
                     VFHQCQQWGNYFLHSGHLHVKGKEEKMSKSLKNYITIKDFLQTFSPDVFRLFCLRTNY
                     RSAIDYSDSTLEEARHLLLGLASFVEDARAYVKGQLICGPVGEDVLWERLASTKKAVK
                     AALANDFDTPRAVNSILDLVHHANRQLRAVSKEAGGPRSPTVFGAIVAYVEQFFETVG
                     ISLAKRQCVSGDSSTVALHCVVDELVRFRLKVRQYALATPGATGEARKQQLQERQPLL
                     EACDALRQDLMTHGINVKDRGHAASTWELLDPRTKHQKPGT"
     misc_feature    122..1693
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     misc_feature    122..1693
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     exon            235..285
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            286..403
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            404..475
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            476..581
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            666..795
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            796..929
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            930..997
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1064
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1203
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1327
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1426
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1633
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1827
                     /gene="Cars2"
                     /gene_synonym="RGD1311612"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcccggc ctgcaggatt ttgccttacg cctgttcgct ggatctgtcc ccaatatgct
       61 gagggcgctc cggcctgggc cgggcgctcc gctgctccgg gccgcgcttg ttctcgggcg
      121 gcgcgggcgg gcatggcaac ggccacaagg ccaggacacc ggtgtgcagg tgcataacag
      181 cctcacaggc aagaaggagc cgctgatcgt gggccgctcg gacgcagtct cctggtatag
      241 ctgtggaccg actgtgtacg accatgcgca ccttggccat gcttgctcat atgtcagatt
      301 tgacatcatc cgaaggatcc tgaccagtgt gtttggatgc aatgttgtca tggcgatgag
      361 cattaccgat gtggatgata aaataatcaa gagagctaac gagatgaacg tgtcgcccgc
      421 ttctcttgcc agcctttttg aggaagaatt taaacaagac atggcagccc tgaaggtcct
      481 gccgccaacc gtgtacttga gagtcaccga gaacatccct cagatcatct ctttcatcca
      541 aggcatcatt gcccatggcc atgcttacgc gacagccaca ggtagcgtct actttgattt
      601 gcgagcacga ggggacaagt atggcaagct ggtcaacacg gttcccagtg cgactgcaga
      661 gccagttgac tctgacaaga ggcacagcag cgactttgcc ctgtggaagg gagccaaacc
      721 ccaggaggtg ttctgggcct caccgtgggg agacggccgg cccggatggc acatcgagtg
      781 ttctgccatg gccagcgagg tgttcggaag ccaactggac atccacaccg gcggcataga
      841 cttggctttc ccacatcatg aaaatgaaat cgcacagagt gaagtcttcc accagtgcca
      901 gcagtgggga aattacttcc tacattcggg tcatttgcat gtgaaaggca aagaagagaa
      961 gatgtccaaa tccctaaaaa actacattac tattaaggac ttcctgcaga ccttctctcc
     1021 cgatgtcttc cggcttttct gcttgcgcac caactatcgg tcagccattg actacagtga
     1081 cagtaccctg gaggaagcca ggcacctcct gctggggcta gcctcttttg tggaggatgc
     1141 acgagcctat gtaaaggggc agctgatctg tggccctgtt ggggaagatg tgctgtggga
     1201 gaggctggct agcaccaaga aggccgtgaa ggctgcacta gccaatgact ttgacacacc
     1261 gagggcagtg aactccatcc tggaccttgt gcaccatgca aacagacagc tcagggcagt
     1321 ctcaaaggaa gctggtggcc cgagaagtcc cactgtgttt ggggccatcg ttgcctacgt
     1381 tgagcagttt ttcgagactg ttgggatttc tctggccaag cgacagtgtg tttcaggaga
     1441 cagcagcaca gtagccctgc actgtgtggt agatgaacta gtgcgcttca ggcttaaggt
     1501 ccgccagtat gcactggcca cgcctggggc caccggggag gcccggaaac agcagctcca
     1561 ggagaggcag cccttgctgg aggcatgtga cgcactccgc caggacctca tgacccacgg
     1621 catcaatgtt aaggacagag gccatgcagc ctccacatgg gaactgctgg atccgaggac
     1681 aaaacaccag aagcccggga cttgaggatg aggcagctgc agtccacgtg cctccacgca
     1741 tggcatctgc tttctttgtg gtgaactttg tattaaaaac tttatattaa agttgctaat
     1801 tgtggctgtt tagccacagt aaagtga
//
LOCUS       NM_001436760            2796 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 5, mRNA.
ACCESSION   NM_001436760 XM_039109756
VERSION     NM_001436760.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_039109756.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.614409.1,
                                           SRR26360172.941679.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN06680429 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               JAXUCZ010000005.1  21321699-21322144   c
            447-533             JAXUCZ010000005.1  21318760-21318846   c
            534-922             JAXUCZ010000005.1  21316424-21316812   c
            923-1087            JAXUCZ010000005.1  21304734-21304898   c
            1088-1281           JAXUCZ010000005.1  21301659-21301852   c
            1282-1342           JAXUCZ010000005.1  21296573-21296633   c
            1343-1482           JAXUCZ010000005.1  21294405-21294544   c
            1483-2796           JAXUCZ010000005.1  21291897-21293210   c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2796
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..446
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    439..441
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="upstream in-frame stop codon"
     exon            447..533
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            534..922
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..1587
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform a is encoded by transcript variant 5;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform a"
                     /protein_id="NP_001423689.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAN"
     misc_feature    904..1524
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    904..1524
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(982..984,991..993,1000..1002,1045..1056,1189..1197)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(982..984,991..993,1000..1002,1045..1056,1189..1197)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            923..1087
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1281
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1342
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1482
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..2796
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcatcc gcaactctct cggctctcgg aacggaccgc cgcagctttt tgtctgaggc
       61 taggcgtatc tcttgtctca tgacggtcca gtcccgcgag cctgatggag ctggagggaa
      121 aagtgagacc ctagtgccga ggccattggt acaggttaga actgttggtg agctgactga
      181 gcagggttgg aatgctggtt tatgctcttt agtacccatg tgacttttgg caagccactt
      241 ggcctctagg agcagcgtct gactacttat aaaaaagggt tgaatagcaa taattatccc
      301 acgaggctcc ggagaggatc caaggaaaca gcacttacaa acttttatat ttgtgcaaat
      361 tcgacttggt ccagatcctg tagatgctgc gctgccgcga tcgctgggtt ttgtaatcag
      421 ttaaacattt gtaagaaata atatgcgttc acccccgctg cagcagggct ctgctctctg
      481 actgagtggt gctgtgttac atggatctgt catttctatt cagtcatcag ttggcattgc
      541 agtaacacct atggcaatga agaaagagac agaatttggg attttcatct aaggaaaatg
      601 ataaataaca accagacgtg tgctgcaggg caggactccg tgccctacgt gacctgtatg
      661 cttcacgtgc tggaagagtg gttgggtgtg gaacagttgg aggactacct gaattttgcg
      721 aaccatctct tgtgggtctt caccccgctg atccttttaa tacttccgta ctttaccatc
      781 ttccttctct accttactat tattttcctc cacatctata agaggaagaa tgtgttaaaa
      841 gaagcctact ctcacaactt gtgggatggc gcgaggaaaa cagtggcaac cctgtgggat
      901 ggacatgcgg cggtttggca tggttatgaa gttcacggga tggaaaagat accagaagga
      961 ccagcactta taatttttta tcatggagct attcccatag acttttacta cttcatggct
     1021 aaaattttca tccacaaagg cagaacttgc cgagtggtag ctgaccactt tgtctttaaa
     1081 atcccagggt tcagtttatt acttgatgta ttttgtgctc ttcatggacc aagagaaaaa
     1141 tgtgttgaaa tcttgaggag tggtcacttg ttagctattt caccgggtgg agttcgagaa
     1201 gccttactta gtgatgaaac ctacaacatc atatggggta atcgtaaagg ctttgctcag
     1261 gttgcaatcg atgcaaaagt gcccattatt cctatgttta cacaaaacat ccgagaagga
     1321 tttagatcac tcggaggaac aagattgttt aaatggcttt atgaaaaatt ccgctatccg
     1381 tttgctccaa tgtatggagg ttttcctgtg aagttgcgga ccttcttggg tgatcctatt
     1441 ccgtatgacc cagaggtaac agcagaagaa ttagctgaaa agactaagaa cgctgttcaa
     1501 gctttgatcg acaagcacca aaggataccg gggaacatta ggagtgcttt gctggaccgc
     1561 tttcataaag agcagaaggc taattgacag ataatttcgt gtgtctctaa tgccaagttt
     1621 gcatctgtgg tactgccttt taaacttttg taggttgtat aatagtcttt ttaaaacctg
     1681 ctaatgagca tctttcttta gaatttaaac tttctatggt taatcttacc ctttcaatca
     1741 gttttgtcaa atgtagtaag taactcacca tttgcttgac tcagaagatg atcatgttgc
     1801 atttgcaatc cttagtagta tatgataggc acaagtcttc ctggatacca gcagtctagg
     1861 ttaggcagac ttcactaaat tatgcttctg tgtttgtgtc tgttgtgcca atgggatggt
     1921 gagaggtacc tgagctgggg tgtagcactt gcttagttta ggtgagcggt gcctttgtat
     1981 ccatccttca ttccactcac aactgctggt aagttgtgaa acgcttttgc acctccgtgg
     2041 tttatgttaa gcatggtaat actgtggtgg tgaacattaa gttgcttatg tctactgtga
     2101 tatatccgta tctatatatc tgatagatat ctgtagtgag aaatctgtaa ttgaattgat
     2161 tcctgaatcc tttaggagtt atgtacattt ttgtttattg ggtattgaaa ttactccttc
     2221 agggatgatg tccagttgcc aagcacaatg aaagagatgt actattttgt aaatcaaatc
     2281 attgttattt gtagtattta ttaacagagt tgtttggtat ttattttaaa caaggatcta
     2341 agtaaatgta taggatggat tgtcagcacg tgtcttacac ggtgtaaaga taaaatcgtg
     2401 ggcacgctct gcagtttatg ttagagcaga tcctaggctg aggagtgaca actgaggaag
     2461 ctctgcctcg cttgtcccag ggctcgcttc cgtgctctgc agccagtcac gtggttatat
     2521 ctgtaaaatg tacttgaatg atgaatttct gtaaacatgg agtcctctga aaatgtaatt
     2581 actttgaatt gttgtcttct tgaaaactta ttttaaaagt atttaaacag ccaagtatca
     2641 tgaattcatc gcagtgtgtc ttcccccttt gcagtacttg ggttttatat ggacttttta
     2701 actacaagtg tatatttgtg atatgtataa tgtatgtata atgtatatag aaatggtgtg
     2761 aaaataaagc tgaactgcaa ctcctctcta gtaaaa
//
LOCUS       NM_001436749            4070 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 2, mRNA.
ACCESSION   NM_001436749 XM_006252574
VERSION     NM_001436749.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006252574.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.37619.1,
                                           SRR26360186.1357613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               JAXUCZ010000016.1  2308404-2308838
            436-529             JAXUCZ010000016.1  2343846-2343939
            530-596             JAXUCZ010000016.1  2401572-2401638
            597-659             JAXUCZ010000016.1  2454533-2454595
            660-767             JAXUCZ010000016.1  2546487-2546594
            768-938             JAXUCZ010000016.1  2562094-2562264
            939-1001            JAXUCZ010000016.1  2566684-2566746
            1002-1098           JAXUCZ010000016.1  2568438-2568534
            1099-1175           JAXUCZ010000016.1  2568687-2568763
            1176-1433           JAXUCZ010000016.1  2576216-2576473
            1434-1604           JAXUCZ010000016.1  2582072-2582242
            1605-1791           JAXUCZ010000016.1  2584906-2585092
            1792-4070           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..4070
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..435
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    405..407
                     /gene="Arhgef3"
                     /note="upstream in-frame stop codon"
     exon            436..529
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..2141
                     /gene="Arhgef3"
                     /note="isoform 1 is encoded by transcript variant 2; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     1"
                     /protein_id="NP_001423678.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSA
                     QDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNE
                     SRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGE
                     EDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDG
                     STEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKL
                     DLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGES
                     ECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTH
                     NEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQS
                     QTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETK
                     LEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
     misc_feature    939..1469
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    939..1469
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1509..1907
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1509..1907
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            530..596
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..659
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..767
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..938
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1001
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1098
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1175
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1433
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1604
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1791
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..4070
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgtcccc gcagtcaccg ctgcggccca gcagggccga gtcagcgggc gaggtaagag
       61 ccgcaggaac atcgcgtcgc ctgatcgtcc ttttacccgc tgcccctacc agagaagagt
      121 ccccatggcc actctgtggc gcgttggata gacagtgcca ctgcctgctt ctgcccgcgt
      181 ccgctcctgc cggggacccc aacttcggtc ctccgatagc tcctgggaga aagttcctgg
      241 agccacttcc gggagggagg cgccacctgt ctggggcgcg ccctgacgct ggacttgtcc
      301 aggtcagtgt ctttggtcac ttggccggga cgcgggtacc accaccgtca gccaggatcc
      361 ttactccgga gaccgcgtct tttaaactgc gcagcggaca gtcttgagat gggaggcgcc
      421 cgcccagagc tgaaggaaag aagagctgga cctggcaagc tgagtctgca gagcatttca
      481 cagtgatgaa tcagtgcatt tacagaggga tggaggagca caaggaaaga cccaagcggc
      541 caaggcagaa caacttctcc atgtttccct ctcccaaagc ctggaatttc agagggcgga
      601 aacggaagca gagtgcccag gatgaagatg ccgtcagcct atgcagtctt gacataagtg
      661 aacctagtaa caaaagggtc aaaccccttt ccagagtcac atcgctagca aacctcatcc
      721 cacctgtgaa gaccacaccg ttaaagcgct tcagccaaac cttgcagcgg tccatcagct
      781 tccgcaatga gagccgcccc gacatcctcg cccctagagc ctggtccaga aatgccacct
      841 cctcaagcac gaagcggagg gacagcaaac tctggagtga gaccttcgat gtgtgtgtca
      901 gtcaggtgct cacagccaag gagatcaaga gacaggaggc aatttttgag ctttctcaag
      961 gtgaagagga tttgatagag gacttgaaat tagcaaaaaa ggcctaccat gaccccatgc
     1021 tgaaactctc aataatgaca gaacaagagc tgaatcagat ttttggaaca ctggactctc
     1081 taatccctct ccatgaagac ctccttagtc agcttcgaga tgttcggaag cccgatggct
     1141 cgacggaaca cgttggtccc atcctcgtgg gctggctgcc ttgtctcagc tcctatgaca
     1201 gctactgcag caatcaagtt gctgccaaag ccctgctgga ccacaagaag caggaccaca
     1261 gagtgcagga tttcctccag cgctgcttag aatcaccctt cagccgcaaa ctcgacctct
     1321 ggaatttcct tgatattccc cggagccggc tagtgaagta ccctctgctc cttcgagaaa
     1381 tcctgaggca tacgccaaac gataatccag accagcagca cctggaagaa gctataaaca
     1441 tcattcaggg aattgtggca gaaatcaaca ccaagactgg ggaatcggaa tgccgttatt
     1501 acaaagagcg gcttctttac ttggaagaag gccagaaaga ttccctgatt gacagctcaa
     1561 gggtcctgtg ttgtcatgga gagctgaaaa ataaccgggg tgtgaaactc catgttttcc
     1621 tgttccaaga agtgctggtg attactcgag ctgtcacgca caatgagcaa ctctgctatc
     1681 agttgtaccg gcagcccatc cctgtgaagg acctcactct ggaagacctg caggatggag
     1741 aagtgcggct gggtggctcc ctgcgtgggg ccttcagcaa caatgagaga attaaaaact
     1801 tcttcagagt cagtttcaag aacggatccc aaagtcagac ccactcactg caagccaacg
     1861 acaccttcaa caaacaacag tggctcaact gtatccgtca ggccaaagaa acggttctgt
     1921 ctgctgccgg gcaggctggc ttgcttgact ccgagagcct gtcccagagt cctggcactg
     1981 agaacaggga gctgcgggga gaaacaaaac ttgagcagat ggaccaatcg gacagtgagt
     2041 cggactgcag tatggacaca agcgaggtca gcctcgaatg cgagcggatg gaacagacag
     2101 acgcttcctg tgcaaacagt aggcccgagg agaacgtctg acagaggctg tgaccctgcc
     2161 agcagcaggc ccgtgtctta cctgtacagt gtttgtattc cacacgggaa cagtttggag
     2221 aggcactttg taatactcct gtgcctgtgt tggcctagcc cctgtgtcta ctccttgtcc
     2281 ctagcactgt aactgccacc cagtctgtgt cagcttgcag cagcccttac cctgttgctg
     2341 tatcccacaa gcatctggat gagtgcggag gaatggacca tgttacttcg agttgtccta
     2401 cattcaaaac agaaagactc tctaaactac tgttgtgcat ggcaaggcct ttgtctcatg
     2461 cttgcctagt gttcctctag ctctgacata gtcgctgaag tcctggcact gggagagctc
     2521 tgcagaatac tgagatcgca ttgaagggaa ggcagaaagt ctgattaacc cttggaggga
     2581 actccagttt tgagttaatt caactagaaa gcatgaaaag catctctggg ggtttctgag
     2641 gttggatttt tgcaaaggag gaagccttgt tttgaagcct gtggtttcat ccagtgcaag
     2701 ttgaatgtga ataatctgtg aagacctgaa acagaggtgg ctttagaaag ggccaagaca
     2761 agagcagctg ccggacaggc aagcagaggc aggaagatgc ggagttcaag aacagccttg
     2821 gctacttacc aaattctagt tcaaactgaa ttccaccgta aaaacaaaac aaagctaaaa
     2881 gcaccagcca gctctgaata ttcagctgaa gttgggggtg gatattggag gcgtttgtca
     2941 tggccaatgg cttgccatta gaagagccct ttctagccta caacatcagg attgccagga
     3001 ccagagaaga tctgccaggg tcatgtgacc ccatcagcat tatgtttcat cctcctcagc
     3061 cactcctctt ttccagtggt aatagggggc tgggggatag ggacacagag actgtgactg
     3121 catccagtga ctgttgacaa acaagagaga aggacttggg ggtgagaaat gtgtcactgt
     3181 cacccaaggc tcctgcgtga accacagaaa ttgaagttac tccggagggt ctcaagattt
     3241 cctgctctgc ttttgggcct ggttctagag ctacagacgg actggtggtt aattcccctc
     3301 gaggctggtt tcattagctc ttattaacta gaaccggcta gccaaactgg aaagttcttt
     3361 gttaaagcct tgctttacag agcaaggatg ggtaaaaaga ccttgagggc gtggtggaaa
     3421 aaaccgttca caaactagac agagcagctt ctgcaagtgt aaatacttag aggatttgta
     3481 taaaattata cccacaccag cactagtagt aatgattcta aattattgcc aaaaagtttt
     3541 ttttgtttgt tgttgttaat ttttgcatct atcaaaagtt tacagaaaag aaagcaaaat
     3601 gcaaagttgt ccctttacta tgcacatgtg tcgtgcgcac tgaaagaagc cgtgtggcaa
     3661 gagcaaccaa tagaaaaaca aggtatatga cattattatt tttcaagacc tattttgacc
     3721 agtttctacc ctgtaaagcc tatttctgta tttatagttt ttaaccatgg tgaaaatttt
     3781 tttctattat gagtttattt aaaaccattt tgtctctcaa gttgctgatg tagcgaataa
     3841 acctgctccg ggcagacaca gtaggaagct gagacggacc gggcactgga cgatagagaa
     3901 aagcctgaaa tgttctctac agagccattg tgaccagcga gttaaggaag ggtctctgtc
     3961 agggtcagcc tgtgggaaga gagtgaatga atgttctggt gaaatgaata cttttgtata
     4021 atggccttaa acttttctgg aagcatttca aataaattgc attaagaata
//
LOCUS       NM_001107898            8466 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 5A1 (Slco5a1), transcript variant 2, mRNA.
ACCESSION   NM_001107898 XM_001064830 XM_232599
VERSION     NM_001107898.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8466)
  AUTHORS   Kindla,J., Rau,T.T., Jung,R., Fasching,P.A., Strick,R., Stoehr,R.,
            Hartmann,A., Fromm,M.F. and Konig,J.
  TITLE     Expression and localization of the uptake transporters OATP2B1,
            OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
  JOURNAL   Cancer Biol Ther 11 (6), 584-591 (2011)
   PUBMED   21278488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001107898.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760475,
                              SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1575              JAXUCZ010000005.1  11013662-11015236
            1576-1708           JAXUCZ010000005.1  11063474-11063606
            1709-1920           JAXUCZ010000005.1  11066263-11066474
            1921-2085           JAXUCZ010000005.1  11081668-11081832
            2086-2284           JAXUCZ010000005.1  11108164-11108362
            2285-2420           JAXUCZ010000005.1  11121588-11121723
            2421-2662           JAXUCZ010000005.1  11123494-11123735
            2663-2727           JAXUCZ010000005.1  11129083-11129147
            2728-8466           JAXUCZ010000005.1  11135442-11141180
FEATURES             Location/Qualifiers
     source          1..8466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..8466
                     /gene="Slco5a1"
                     /note="solute carrier organic anion transporter family,
                     member 5A1"
                     /db_xref="GeneID:312907"
                     /db_xref="RGD:1307132"
     exon            1..1575
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    609..611
                     /gene="Slco5a1"
                     /note="upstream in-frame stop codon"
     CDS             660..3188
                     /gene="Slco5a1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 5A1 isoform 2"
                     /protein_id="NP_001101368.1"
                     /db_xref="GeneID:312907"
                     /db_xref="RGD:1307132"
                     /translation="MDEGAAQSRAQEQLEAPSLVGAVQENFESESFRSKSLPVLHSAS
                     CRQNLSAGNADGKLALGSIEASGHQETHPGRNLIVPSPSAPSTSAGTTTELMDCNHRR
                     DPSKTVSVSSTLATLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIE
                     RRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALP
                     HFISPPYQIQELNASASNDGLCQNGNSTAILEPPPCPKDSGGNSHWIYVALFVCAQVL
                     IGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPR
                     NPVLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKFSADVVSD
                     DDIIKEKSNTSEQVNKKVSSMGFGKNVRDLPRAAVRILSNMTFLFVSLSYTAESAIVT
                     AFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLA
                     MICSGVSLLCFSTLFIVGCESINLGGINIPYTTGNLTGSCNVNCGCKIHEYEPVCGSD
                     GITYFNPCLAGCINSGNLTTGVRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLN
                     ENGYAVSGKCKRACNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQ
                     FVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKF
                     VGFIFIFLAWYSIKYKEDELQRRRCRDFPLSTVSEHVGRPSKAEKYSRTTSCPAFSTQ
                     GESHEETALQKGFPGTTLTYPGPFSEAESSSADRGLDESLDAAL"
     misc_feature    1050..2663
                     /gene="Slco5a1"
                     /note="Solute carrier organic anion transporter 5 family
                     of the Major Facilitator Superfamily of transporters;
                     Region: MFS_SLCO5_OATP5; cd17404"
                     /db_xref="CDD:340962"
     misc_feature    1050..2663
                     /gene="Slco5a1"
                     /note="Solute carrier organic anion transporter 5 family
                     of the Major Facilitator Superfamily of transporters;
                     Region: MFS_SLCO5_OATP5; cd17404"
                     /db_xref="CDD:340962"
     misc_feature    order(1092..1097,1104..1109,1116..1118,1212..1214,
                     1500..1505,1509..1517,1524..1526,1584..1586,1593..1598,
                     1605..1607,1983..1985,1992..1997,2004..2012,2019..2021,
                     2106..2108,2118..2120,2241..2246,2256..2258,2268..2270,
                     2430..2432,2439..2444,2451..2456,2463..2465)
                     /gene="Slco5a1"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340962"
     misc_feature    order(1092..1097,1104..1109,1116..1118,1212..1214,
                     1500..1505,1509..1517,1524..1526,1584..1586,1593..1598,
                     1605..1607,1983..1985,1992..1997,2004..2012,2019..2021,
                     2106..2108,2118..2120,2241..2246,2256..2258,2268..2270,
                     2430..2432,2439..2444,2451..2456,2463..2465)
                     /gene="Slco5a1"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340962"
     exon            1576..1708
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1920
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2085
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2284
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2420
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2662
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2727
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..8466
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctcatt gttcggggac ttgaggctgc agtctctgcg ggttcttcct gcaccgttca
       61 gctcctagct agcacttcgg tccctccggg gaccacgggg ttacttagca ctagcccccg
      121 gccgccggga tgccagcccc acgtgcagcc atccttctct gaccatccat cctctgcttt
      181 acaggtcggc agctttacga ccccatgtgt ctcaagcctt gcagtgggca ccgaacaccc
      241 ctgggaccac aaagtgggat gttgttcgga caatcgcctt aagtgacccg gtactgggcc
      301 caggtcgctc cagcttctgg ccaccgtctg agagacggcg gcggagggga tgagcaccgg
      361 acgcgcaaag cgcctaccgc gagctatccc cgggaggtgg acacctagca gggctcctcg
      421 aaggaccgcg cggaccttta cctcccccgg tacaaggtgg agaaaacttc ctgttgtgcc
      481 tcggggatag atgctctggg cacctcccta ctgctgagat gttctgcttt caggttctgc
      541 catcctcagc ccgggtctct ggaggggacg actgagtggg tccgacatca gcccatcctg
      601 caggtggatg aaaattgccg gaggccttgt atgggatcag caatcacatt ttaagagcca
      661 tggacgaagg ggctgcgcag tcccgggccc aagaacagct agaggcacct tccctggtag
      721 gagctgtcca agagaacttc gagtcggagt ccttcaggtc caagagttta ccggtcctgc
      781 acagcgcctc ctgccggcag aatctcagtg ctgggaatgc agatggcaaa ctggccttgg
      841 gcagcattga agcttcaggt caccaggaga cacatcctgg acggaacttg atagtcccta
      901 gcccttctgc tccatctact tctgcaggca ctacaacgga actcatggac tgtaatcaca
      961 ggagggaccc cagcaaaact gtgtcagtat cttccacttt ggccacactc caggagagaa
     1021 ggtgtcttta cgtggtcctt acggattctc gctgcttcct agtgtgcatg tgttttctga
     1081 ctttcatcca ggcgttaatg gtctcgggct atctgagcag cgtcatcacc accatcgaaa
     1141 ggcgctatag cctgaagagt tcggagtcag ggctgctggt cagctgcttt gatataggaa
     1201 acctagtggt ggtggtgttc gtcagctact ttggtggccg tgggagaagg cccctgtggc
     1261 tggccgtggg tggacttctt atcgccatcg gggctgcgct cttcgcctta cctcacttca
     1321 tctcgcctcc ctatcaaatc caagagttga atgcttcggc ctccaatgat ggcctttgtc
     1381 agaatggcaa ctccacagcc atcttggagc ctcctccctg tcccaaggac tcgggaggaa
     1441 acagtcactg gatctacgtg gctttatttg tctgtgcaca ggttctcatt ggaatgggct
     1501 ccacgccgat ttacaccctg ggaccaacct atttagatga caacgtcaag aaagacaatg
     1561 cgtccttgta cctagccatc atgtacgtca tgggtgcact tggccctgca gtgggatact
     1621 tactaggtgg gctactcatt ggcttttatg tggatcccag aaatcccgtt ctccttgatc
     1681 agaatgaccc tcgtttcatc ggaaactggt ggagtggatt ccttctttgt gccattgcaa
     1741 tgtttcttgt gatattccca atgtttactt ttccaaaaaa gcttccacct cgacacaaga
     1801 aaaagaaaaa attttctgcc gatgttgtta gcgacgatga catcatcaag gagaaatcaa
     1861 acacaagcga gcaagtgaac aaaaaagttt cctcaatggg ctttggaaag aatgtcagag
     1921 acctaccgag agcagctgtc aggatcttaa gcaacatgac attccttttt gtgagtctgt
     1981 catacacagc cgagagtgcc attgtcaccg ctttcattac cttcatcccc aagttcatcg
     2041 agtcacagtt tggtatcccg gcttccaatg ccagcatcta cactggtgtc atcattgtcc
     2101 ccagcgctgg tgttggcatt gtcctgggag gctacatcat aaaaaaactg aagctcggtg
     2161 ccagggaatc tgcaaaactc gcaatgatct gcagtggggt gtctttgctg tgcttctcaa
     2221 ccctgttcat tgttggatgt gaaagcatta acctgggagg cataaacatc ccttacacaa
     2281 cggggaatct gacaggaagt tgtaatgtta attgtggttg taaaatacat gaatatgaac
     2341 cagtctgtgg atcagatggg atcacgtact tcaacccttg tctggctggc tgcattaaca
     2401 gtggcaatct taccacgggg gtccgaaatt acacagagtg cacttgtgtc caaagccgac
     2461 aagtgatcac cccgcccaca gtggggcagc gcagccaact tcgagtggtc atcgtgaaga
     2521 cctatctcaa tgagaacggc tacgctgtgt ctgggaaatg caagcgagcc tgcaataccc
     2581 tcatcccctt cttggtcttc cttttcatag ttaccttcat cacagcgtgt gctcaaccgt
     2641 cagccattat agtgacactc aggtccgtgg aagatgagga aaggcccttc gcattgggga
     2701 tgcagtttgt tctgctgcga acacttgcat acattcctac tccgatttac tttggagccg
     2761 tgattgacac cacctgtatg ctctggcagc aggagtgcgg agtgcagggc tcctgctggg
     2821 agtacaacgt gacgtcattt cgtttcgtct actttggcct ggcggctggc ctcaagtttg
     2881 ttggctttat tttcattttc ctggcctggt actctatcaa gtacaaagag gacgagctgc
     2941 agaggcggcg gtgcagagac ttcccgctga gcactgtgag cgagcatgtg ggccggccca
     3001 gcaaagccga gaaatactcc cggactacat cgtgcccagc cttcagcacc cagggggaat
     3061 cccacgagga aactgctctg cagaagggat tcccgggcac cacactgaca tatcctggac
     3121 ctttctcaga agcagaaagt tcctctgcag accgagggct ggacgagagc ctcgatgccg
     3181 ctctgtagca tccctgctgg agcctggaga aggaagactt gtgttgttgg ttgagttgaa
     3241 cacggcaagt tgagaaacac ctgtgccttc tttccttttg taaacctcca cagacacaat
     3301 cctcaaacca acaatactca gtacacacag ccactgttgc tgagggctcg gtacctcaac
     3361 gggacggaca gcttccccct ccagggagga gtttagctgg atctgccgcc atgtctgcta
     3421 ggttcactta atgttcacag tccctttggg tagaagcccg aggtccacgg ttaaccgcgg
     3481 gaaaggctat gaccatacat atcattagca tacactccag acaaaggtga gcttcaccag
     3541 gactttgcat ttgcaagtca agagttttta gatttgagca cctactgtga gctctgcagc
     3601 aaagcacaac tgaatttgcc tcaactatgc aatttgattg gaaatagaaa agtgtggcat
     3661 gtccctttgg ctttcagaga gcaaagcaga aacgtttttc cttagtggaa gctgaatgtt
     3721 ccctaaagca ctgttaatcg caatttaagc cataacagac ttatcaatca ggtaaaaaaa
     3781 aaaaaacctt caaatgcttc aatgcttcaa agaactgtat tattgtgcaa tggaagggtt
     3841 tcttgagaag tattttctct aagtccattc actccatctt aaggtagacc aagaggctgc
     3901 tgagtcgcac gtctgctggc ttgaatatat aaactacagt attctttcct aaggggcttt
     3961 aaaactagtg tgctaaacag tacggctgga aactaatctg agatgctcga tggggaggaa
     4021 atgatgatct tctcttccga ggaactctcg cagctctaag ggcccactga aactcgctaa
     4081 gagttactgc tactttgaca tacaaagtag ttgataaaga aaatcctgag gtaagatgga
     4141 gtcccaacta gggaacttca cttctctctt aacatactgg caaatctcta ctgattgttt
     4201 tctctgtgtg gaaggtggtc atggttgcct tggagaatga atgattcagt catgaaagct
     4261 gtaccgtgga tatgaaaatc actgcccagc agacgggagg tttgtcagct gaacacagaa
     4321 tatgatcata cttaaataac gagttggaat gtaaagaaag ccagtctgcc atactgaatc
     4381 ctgtatggca ggattcatcg tttcacggtg ccctttgcat ggccgttctt ctgtctttcc
     4441 tcaagtggct ctgagacagg ataattccct tcctaaaggc acctcaggtc cactgacagc
     4501 tgtttatctt tgtctctcgg ctttaggctg ctcaggatgc tttctgtatg gtgttcttac
     4561 gtcagaggcc tcttggcaaa cctttgtgca tccaacagtt ggtaactcat gggatctggc
     4621 tacactggac caagatgtcc aatgcaccat aaaattatag cctctctgtc aaagaactca
     4681 tgtcatgtaa ggtgacctca ggaaatgttt cctcgtctgg aagagaggtg gctgacagaa
     4741 gggccatgat ccattcaatc ttggcagggc acacaggtag aattatgaat attcttatta
     4801 cagttcctgg tatagaattg acttcctgcc cgtgtaggaa gcccacaagt caagtggttt
     4861 tctgggtaat gtctataaga ggcagagcta gtgcctaggt gaaaagaatc ttctttgact
     4921 cctgggcttg gctgccatgg aggtgggatg cttagctagg atagattgtg aatgctgggt
     4981 gtcagatttt tgaccagagt aacaaacatg agaggttttc ataaagtctt gcaggtcagc
     5041 ccacggtgta ctcttgggag ttggtgtccc tcactggcct ctgtgggtga ctgtcattct
     5101 ttagaaggga taataagtgt cctttggtgt tgatgctaag ctgattaggt tgtagagagg
     5161 tggtgctttc ttaatttttt tctgtgatat taagatattt tattaagaaa cttctggtgg
     5221 aattggtcct gttttggtac taagattgat gggctcacca agggtgatta gaacgcttct
     5281 ggtcccttcc tctaccttga attcagttca gcagtttctg actgagcact ggttatgtgt
     5341 tgatgccatt cattgctcct tgagatccta tgggatgcag aggtcagaac tcgaagacct
     5401 tggaagtgca ctacagcatg caaatattaa atattgatat taagtagcag gtgtatcatt
     5461 aatgtactag tggtgattgt acactaggtc ctgaaagtca tgagggaatg aagttctgca
     5521 ttctatatca gttaaagatt gctccccaga tgtcttagct ccagtagcat catctgaata
     5581 ttgcatagcc acggagtgag tatttcatag gcagtgccat tcaattgtgc tgatagaaga
     5641 ggtcttccgt ttctggcaaa ctggttgctt tccttgtggc cgcagctcgt aacagaaact
     5701 aactgctttc tgagcatagg cttttgggtt gttttgacaa aaggcaagtt gttcttgtat
     5761 catctctata aattaaattg tcttgtttgg cttcagtatg ccaatctaat acgaagctta
     5821 tggacttaga aactcccaag ggcagaggga ggaaggtggt ggaggaacct tcttttgatt
     5881 ttcttcctag tatgaggttc ttgtgttgtg gaggtgccct cacaggttga agagagttaa
     5941 aagtcatttg gaacaccatg aggatgggga gaaagagagc atttgttggg gtgaatattt
     6001 gcaggatggt ttcccagcat tcaacaccca ctgcattttc cagtttaaga gcgggcgagg
     6061 aaacacggtt tccttcagtg gcgcaggcct gagctcagga ccttgcatat gacctcaggc
     6121 ccatgttccc tgagcagcac cccagtcttc tctggagagc attttttatt tgtttgttta
     6181 aaaagcagat ttgaaaccct aggctcagaa agttgaagcc agttcttcgg gtggctcaga
     6241 gtagcagtga caggggatga gtgatatgtc cactgtaaaa taggttagca cctatcactg
     6301 tttgatgtac tattgttttt gaagttatag agacattctt tagagacatt tatttccttg
     6361 tatgaataga ggaaacatag cacacgcccg tgtgaaccac ccacacttca tgtttaacta
     6421 gattctcaaa gtaaatgtta tttatgtagc caagtataat actaaaatca ttcattataa
     6481 cttacttcaa atgtttattt atgggttgag tttaattgag aacacaccca gtttggttat
     6541 taattaggat cttagcagaa tttcctaaag tgaaatgtta tgaagaaagg gttaattctg
     6601 gctggttgaa tctgagcttt gggtgtttca ggtgtattat ttatttcttt ctcttgtcag
     6661 tagattaaca tttctgctaa ctcatagaca gccgtgggtt ttcagagtct tagtgaagat
     6721 ttaaaaagaa catagaaaat ggactacaaa ccacagactc cgtctgtcac ctcaggtgac
     6781 tgtgatggta aactatatct ttgcactcag ggaagccagc acccacagga gttgctagag
     6841 tggggctccc agaggtctca gaaatcctgt ctcaccaacc atccaaaact tctgttcggt
     6901 ccacagttct agctcacagt ctttgatgaa cttctagcca ggaagtgtct tctttgtttt
     6961 gtttttgagg ctgcttcgta gaaccctgtg tgcaccaagg aacatcacta cagtgtggag
     7021 ggacccaaag cccccatggg aactctccca tgagctctgt agcaaggcaa gcacttgcct
     7081 aaggtgctag ctgataataa cttgtgacag tacgtgtgtg tgtgtgtgtg tgtgtgtgtg
     7141 tgtgtgtcta gaggtgcaga gtgtgaaggt atctgttgct acataggtac atgctgagta
     7201 ttctacgtag cagatagaaa ccagaatgtt gtaagtccct gaaaagccag attcgctaat
     7261 tctgttctgc agacttgtga gtagccttcc gcggtcagga gggatggctg gcaggtgagg
     7321 ctagtggcct cgtgtacttt gccttttccc tcttctgtca actcaccttt actggtagtt
     7381 tgtggtctac ctgactgtcg aaggccaaga agatactgct ggcgttgtct gtcccagact
     7441 tcctgttgtg ctgcttcaac cagatttgtg tttgtctgaa gaggtttaat ttaagcagtt
     7501 catttgtcct cagccttatg gagggtcaaa tgtgaccaga aactcacctt actgctgttg
     7561 gctttggcaa cattaaatat aaaatgcctc ggtgctaaag tgtttgcaga cgcatgttcc
     7621 tctctgaagt cagtgtttca gtgctttgcg tttggaaatc tgggggttcc cccgagagga
     7681 caaaccccgc tgacttcatt tccacagtcc agaaactcta atgcaaaact gggaagtgta
     7741 ctggggagtc ctcttctaca caaaggtcag tgggagaatg atcagatgct aaaaaataat
     7801 ttcagagaga taaaaacaca tttagataat cttctatctt ctacggaaag tttcaagccc
     7861 tgggagctgc tcttcagctc tgggttggat gctgttgtct ctgactggta gtttactcta
     7921 tatatggaaa gtaaagaaac taatgttatt gaaaacaaaa gtaatggtaa ggctgttcta
     7981 aagtaaaccg aggagtaaga ctccccagtg ggcatttgtc ttcagtatat acctctaccc
     8041 caaacttaaa tgatgatcta gagaatgaag tccaaggcca gcctttactt tgtagtgtaa
     8101 ggaaatgtga aactgtgtca aactggtatt aggatatctg tggagtgtgc gtatgtgcgt
     8161 gtgtgtgtgt gtgtgtgtgc gtgtgtgtat ctttctggct gtgtgtctat gtgcttctct
     8221 gtagaggcat gtttgtgatg aaaggctgct ttgagtcata atgtagagtt tcatttttgt
     8281 ggtttttaga acaaatattt atttggagat ctgctatggt aagggccgta tgacttactt
     8341 ctttatgtct aatgaaactg attgtcaaag gactaataaa cctgggttta caacatcatg
     8401 aatacttgat tattgaaaat taaggggggg aaaagttcaa aaaaaataaa gtgtgttgga
     8461 ttgaaa
//
LOCUS       NM_001436754            4043 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 8, mRNA.
ACCESSION   NM_001436754
VERSION     NM_001436754.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1987617.1,
                                           SRR26360186.366512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               JAXUCZ010000016.1  2308429-2308838
            411-504             JAXUCZ010000016.1  2343846-2343939
            505-571             JAXUCZ010000016.1  2401572-2401638
            572-632             JAXUCZ010000016.1  2454533-2454593
            633-740             JAXUCZ010000016.1  2546487-2546594
            741-911             JAXUCZ010000016.1  2562094-2562264
            912-974             JAXUCZ010000016.1  2566684-2566746
            975-1071            JAXUCZ010000016.1  2568438-2568534
            1072-1148           JAXUCZ010000016.1  2568687-2568763
            1149-1406           JAXUCZ010000016.1  2576216-2576473
            1407-1577           JAXUCZ010000016.1  2582072-2582242
            1578-1764           JAXUCZ010000016.1  2584906-2585092
            1765-4043           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..4043
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..410
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..504
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..571
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..632
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    630..632
                     /gene="Arhgef3"
                     /note="upstream in-frame stop codon"
     exon            633..740
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..911
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..974
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1071
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             990..2114
                     /gene="Arhgef3"
                     /note="isoform 4 is encoded by transcript variant 8; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     4"
                     /protein_id="NP_001423683.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTE
                     HVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLW
                     NFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECR
                     YYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQ
                     LCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTH
                     SLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQ
                     MDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
     misc_feature    1008..1442
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1008..1442
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1482..1880
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1482..1880
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            1072..1148
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1406
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1577
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1764
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..4043
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagcagg gccgagtcag cgggcgaggt aagagccgca ggaacatcgc gtcgcctgat
       61 cgtcctttta cccgctgccc ctaccagaga agagtcccca tggccactct gtggcgcgtt
      121 ggatagacag tgccactgcc tgcttctgcc cgcgtccgct cctgccgggg accccaactt
      181 cggtcctccg atagctcctg ggagaaagtt cctggagcca cttccgggag ggaggcgcca
      241 cctgtctggg gcgcgccctg acgctggact tgtccaggtc agtgtctttg gtcacttggc
      301 cgggacgcgg gtaccaccac cgtcagccag gatccttact ccggagaccg cgtcttttaa
      361 actgcgcagc ggacagtctt gagatgggag gcgcccgccc agagctgaag gaaagaagag
      421 ctggacctgg caagctgagt ctgcagagca tttcacagtg atgaatcagt gcatttacag
      481 agggatggag gagcacaagg aaagacccaa gcggccaagg cagaacaact tctccatgtt
      541 tccctctccc aaagcctgga atttcagagg gcggaaacgg aagcagagtg cccaggatga
      601 agatgccgtc agcctatgca gtcttgacat aagaacctag taacaaaagg gtcaaacccc
      661 tttccagagt cacatcgcta gcaaacctca tcccacctgt gaagaccaca ccgttaaagc
      721 gcttcagcca aaccttgcag cggtccatca gcttccgcaa tgagagccgc cccgacatcc
      781 tcgcccctag agcctggtcc agaaatgcca cctcctcaag cacgaagcgg agggacagca
      841 aactctggag tgagaccttc gatgtgtgtg tcagtcaggt gctcacagcc aaggagatca
      901 agagacagga ggcaattttt gagctttctc aaggtgaaga ggatttgata gaggacttga
      961 aattagcaaa aaaggcctac catgacccca tgctgaaact ctcaataatg acagaacaag
     1021 agctgaatca gatttttgga acactggact ctctaatccc tctccatgaa gacctcctta
     1081 gtcagcttcg agatgttcgg aagcccgatg gctcgacgga acacgttggt cccatcctcg
     1141 tgggctggct gccttgtctc agctcctatg acagctactg cagcaatcaa gttgctgcca
     1201 aagccctgct ggaccacaag aagcaggacc acagagtgca ggatttcctc cagcgctgct
     1261 tagaatcacc cttcagccgc aaactcgacc tctggaattt ccttgatatt ccccggagcc
     1321 ggctagtgaa gtaccctctg ctccttcgag aaatcctgag gcatacgcca aacgataatc
     1381 cagaccagca gcacctggaa gaagctataa acatcattca gggaattgtg gcagaaatca
     1441 acaccaagac tggggaatcg gaatgccgtt attacaaaga gcggcttctt tacttggaag
     1501 aaggccagaa agattccctg attgacagct caagggtcct gtgttgtcat ggagagctga
     1561 aaaataaccg gggtgtgaaa ctccatgttt tcctgttcca agaagtgctg gtgattactc
     1621 gagctgtcac gcacaatgag caactctgct atcagttgta ccggcagccc atccctgtga
     1681 aggacctcac tctggaagac ctgcaggatg gagaagtgcg gctgggtggc tccctgcgtg
     1741 gggccttcag caacaatgag agaattaaaa acttcttcag agtcagtttc aagaacggat
     1801 cccaaagtca gacccactca ctgcaagcca acgacacctt caacaaacaa cagtggctca
     1861 actgtatccg tcaggccaaa gaaacggttc tgtctgctgc cgggcaggct ggcttgcttg
     1921 actccgagag cctgtcccag agtcctggca ctgagaacag ggagctgcgg ggagaaacaa
     1981 aacttgagca gatggaccaa tcggacagtg agtcggactg cagtatggac acaagcgagg
     2041 tcagcctcga atgcgagcgg atggaacaga cagacgcttc ctgtgcaaac agtaggcccg
     2101 aggagaacgt ctgacagagg ctgtgaccct gccagcagca ggcccgtgtc ttacctgtac
     2161 agtgtttgta ttccacacgg gaacagtttg gagaggcact ttgtaatact cctgtgcctg
     2221 tgttggccta gcccctgtgt ctactccttg tccctagcac tgtaactgcc acccagtctg
     2281 tgtcagcttg cagcagccct taccctgttg ctgtatccca caagcatctg gatgagtgcg
     2341 gaggaatgga ccatgttact tcgagttgtc ctacattcaa aacagaaaga ctctctaaac
     2401 tactgttgtg catggcaagg cctttgtctc atgcttgcct agtgttcctc tagctctgac
     2461 atagtcgctg aagtcctggc actgggagag ctctgcagaa tactgagatc gcattgaagg
     2521 gaaggcagaa agtctgatta acccttggag ggaactccag ttttgagtta attcaactag
     2581 aaagcatgaa aagcatctct gggggtttct gaggttggat ttttgcaaag gaggaagcct
     2641 tgttttgaag cctgtggttt catccagtgc aagttgaatg tgaataatct gtgaagacct
     2701 gaaacagagg tggctttaga aagggccaag acaagagcag ctgccggaca ggcaagcaga
     2761 ggcaggaaga tgcggagttc aagaacagcc ttggctactt accaaattct agttcaaact
     2821 gaattccacc gtaaaaacaa aacaaagcta aaagcaccag ccagctctga atattcagct
     2881 gaagttgggg gtggatattg gaggcgtttg tcatggccaa tggcttgcca ttagaagagc
     2941 cctttctagc ctacaacatc aggattgcca ggaccagaga agatctgcca gggtcatgtg
     3001 accccatcag cattatgttt catcctcctc agccactcct cttttccagt ggtaataggg
     3061 ggctggggga tagggacaca gagactgtga ctgcatccag tgactgttga caaacaagag
     3121 agaaggactt gggggtgaga aatgtgtcac tgtcacccaa ggctcctgcg tgaaccacag
     3181 aaattgaagt tactccggag ggtctcaaga tttcctgctc tgcttttggg cctggttcta
     3241 gagctacaga cggactggtg gttaattccc ctcgaggctg gtttcattag ctcttattaa
     3301 ctagaaccgg ctagccaaac tggaaagttc tttgttaaag ccttgcttta cagagcaagg
     3361 atgggtaaaa agaccttgag ggcgtggtgg aaaaaaccgt tcacaaacta gacagagcag
     3421 cttctgcaag tgtaaatact tagaggattt gtataaaatt atacccacac cagcactagt
     3481 agtaatgatt ctaaattatt gccaaaaagt tttttttgtt tgttgttgtt aatttttgca
     3541 tctatcaaaa gtttacagaa aagaaagcaa aatgcaaagt tgtcccttta ctatgcacat
     3601 gtgtcgtgcg cactgaaaga agccgtgtgg caagagcaac caatagaaaa acaaggtata
     3661 tgacattatt atttttcaag acctattttg accagtttct accctgtaaa gcctatttct
     3721 gtatttatag tttttaacca tggtgaaaat ttttttctat tatgagttta tttaaaacca
     3781 ttttgtctct caagttgctg atgtagcgaa taaacctgct ccgggcagac acagtaggaa
     3841 gctgagacgg accgggcact ggacgataga gaaaagcctg aaatgttctc tacagagcca
     3901 ttgtgaccag cgagttaagg aagggtctct gtcagggtca gcctgtggga agagagtgaa
     3961 tgaatgttct ggtgaaatga atacttttgt ataatggcct taaacttttc tggaagcatt
     4021 tcaaataaat tgcattaaga ata
//
LOCUS       NM_001436724            2761 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22),
            transcript variant 3, mRNA.
ACCESSION   NM_001436724 XM_063275359
VERSION     NM_001436724.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_063275359.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.46545.1,
                                           SRR26643299.58218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               JAXUCZ010000016.1  8512516-8512859
            345-544             JAXUCZ010000016.1  8535616-8535815
            545-632             JAXUCZ010000016.1  8564932-8565019
            633-761             JAXUCZ010000016.1  8611088-8611216
            762-969             JAXUCZ010000016.1  8626516-8626723
            970-1102            JAXUCZ010000016.1  8630072-8630204
            1103-1176           JAXUCZ010000016.1  8630924-8630997
            1177-1298           JAXUCZ010000016.1  8631987-8632108
            1299-2184           JAXUCZ010000016.1  8634177-8635062
            2185-2761           JAXUCZ010000016.1  8637247-8637823
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2761
                     /gene="Arhgap22"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
     exon            1..344
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Arhgap22"
                     /note="upstream in-frame stop codon"
     CDS             311..2413
                     /gene="Arhgap22"
                     /note="isoform 2 is encoded by transcript variant 3; rho
                     GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22 isoform 2"
                     /protein_id="NP_001423653.1"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
                     /translation="MLSPKIRQARRARSKSLVMGEQSRSPGRPLAPHKLGPVLKAGWL
                     RKQKSIMKNWQQRWFVLRGDQLFYYKDKDEGKPQGFISLQGTQVTELLPDPDDPGKHL
                     FEITPGGAAEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLEDT
                     VHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLF
                     DSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNL
                     PQANYNLLRYICRFLDEVQAHSDVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLV
                     QHLMTVLIRKHGQLFATPSFEEPASPRGTVQGTVEWGSEEVTRDHQGEPGSSGLPTHR
                     TSSLDGPAAAVLSRTSPPRLGSQAGPAATSPGKRMHTLPGWKSSFRQQGSRSESPKGV
                     SSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSHLSS
                     TASVASTAWSVASSSREASIGSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHPSP
                     DLGHSLDEACVGSGSSEPNDPGSPSQAHVRRCRALQGQVAELRAELCHQRIEYQRSLK
                     SIEEGNSDLRKQMCRLEEELDQEKKKYAMLEIKLRNSERAREDAERRNQLLQREMEEF
                     FATLGSLTAGTKGARAPE"
     misc_feature    416..763
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    416..763
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    761..1357
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    761..1357
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    order(893..895,1004..1006,1016..1018,1229..1231,
                     1238..1243,1313..1315)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    order(893..895,1004..1006,1016..1018,1229..1231,
                     1238..1243,1313..1315)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    893..895
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    893..895
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    <1406..>2353
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1406..>2353
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <2084..>2356
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <2084..>2356
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            345..544
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            545..632
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            633..761
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            762..969
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1102
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1176
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1298
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2184
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2761
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaatgggt agccccgcgt gcgcgaactg gatagccagg cgggccccgc cctggcccgt
       61 gattgatcac cgaagatcac tgtggcttta atggtccgct tggatgaaaa ttaattctgg
      121 aatggataaa taatgcatca ggatttatgt agtccaaggc aagccggagc cagaagaggg
      181 agcggaggga gtgacgccag tggccccagg gctcgaagga gctgggcatg aagggccact
      241 ggccaagaag agaaaaggga agcagatggc agcatgatcg gcccagcggg tctggccagg
      301 tggctgcagc atgctgagcc caaagatcag acaggccagg agggctcgct ccaagagcct
      361 ggtgatgggg gaacagagcc ggagcccagg gaggcccctg gccccccaca agctgggccc
      421 tgtactcaaa gccggctggc tgaggaagca gaagagcatc atgaagaact ggcagcagcg
      481 gtggtttgtg ctgcgtgggg atcagctctt ctactacaaa gacaaagatg agggcaagcc
      541 ccagggattt atttctctac aagggacaca agtgactgag cttcttccag accctgacga
      601 cccaggaaag cacctgtttg agattacacc aggcggtgcc gcagagcggg agaaggtgcc
      661 agccaatcct gaggcgctcc tgctcatggc cagctcccag cgtgatatgg aggactgggt
      721 gcaggccatc cgccgagtca tctgggcccc gctgggcgga gggatctttg ggcagcgact
      781 ggaggacaca gtgcaccatg agcggaagtt tggtccccgg ctggcacctc tgctggtgga
      841 gcagtgtgtg gacttcatcc gggagcgagg actcagtgaa gaggggctct tccgtatgcc
      901 cggccaggcc aacctggtga gggacctgca ggattccttc gactgtgggg agaagccgct
      961 gtttgacagc accacagacg tgcacacagt ggcctccttg ctgaagctct accttcggga
     1021 gctcccggag ccggtcatcc ctttcgccag gtatgaggac ttcctcagct gcgcccagct
     1081 gctcaccaag gacgaggggg aggggaccgt ggagttggcg aaacaagtga gcaaccttcc
     1141 tcaggccaac tacaacctgc tcagatacat ctgcaggttt ctggatgaag tgcaggccca
     1201 ctcagacgtc aacaagatga gcgtccagaa cttggcaact gtctttggcc ctaacatcct
     1261 ccggccacag gtggaggatc cagtcaccat catggaaggc acatctttgg ttcagcatct
     1321 gatgactgtc ctcatccgaa aacacggaca gctctttgcc acgccctcct ttgaagaacc
     1381 tgcttcacca cgtggtactg tccagggcac agtagagtgg ggctctgaag aggtcaccag
     1441 agaccaccag ggcgagcctg ggagctctgg cttgcccaca cacaggactt cctctctgga
     1501 tgggccagct gcagcagtgc tctctagaac ttctccgcca cgccttggca gccaagccgg
     1561 ccctgcggcc accagccctg ggaagaggat gcatactttg cctggctgga agtcttcttt
     1621 tcggcagcag gggtcccggt cagagagccc aaagggggtc agctcatcct tagaggtacc
     1681 catcatctcc tctggtggga actggctcat aaacgggcta tcgtctcttc gcagccaccg
     1741 tcgggcctca tcaggggacc ggcttaagga tacaggctca gcacagagac tctccaccta
     1801 tgataacgtg ccaccatcca gccacctttc tagcactgcc agcgtggcca gcacggcatg
     1861 gtctgtagcc tcatcctccc gagaggcctc catcggcagc tgcactgcct gccgggccag
     1921 caactcttct gcctgcagct ccttacacac tgagtgggca ctcgagccct ctcctctccc
     1981 cagcagcagt gagggccacc cgtccccgga cctgggccac agcttggatg aggcatgtgt
     2041 gggcagtggc agcagtgagc ccaatgaccc gggcagtccc tcacaggccc atgttcgccg
     2101 ctgccgggct ctccagggcc aggtggccga gctcagggcg gagctgtgtc accagaggat
     2161 tgagtaccag aggagcctga aaagcatcga ggagggcaat tctgacctgc ggaagcagat
     2221 gtgtcggttg gaagaggagc tggaccagga gaagaagaag tatgccatgc tggagatcaa
     2281 gcttcggaac tccgagcgag cacgtgagga cgcagagcgc aggaaccagt tgctgcagag
     2341 ggagatggag gagttcttcg ccaccctggg aagcttgact gctgggacca aaggggccag
     2401 agccccagag tgaaaggagc ggaagcgcat gtccacctat gtccactcac tttccctgca
     2461 gggctggcca caggctgcag aggaagccgg gagcttcaag tttgggccag gccaccagca
     2521 gggtcatctg cctccaagtg ccagatagag aggggcctga cgccagaatg ggtactgtca
     2581 ggatcccaca tagtccaggc aggatctgga tacttctcca cacatacggg tcccaggagg
     2641 tgtcaggggc gatggtgcca agatcatgag catcagcctc tcctccagga agagtcagtc
     2701 cccagtggcc acctggagag ccaggccacc gccaagaact attaaatgtg ctctgaaagc
     2761 a
//
LOCUS       NM_001436750            3688 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 3, mRNA.
ACCESSION   NM_001436750 XM_017600023
VERSION     NM_001436750.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_017600023.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.888507.1,
                                           SRR26643288.54894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000016.1  2308404-2308456
            54-147              JAXUCZ010000016.1  2343846-2343939
            148-214             JAXUCZ010000016.1  2401572-2401638
            215-277             JAXUCZ010000016.1  2454533-2454595
            278-385             JAXUCZ010000016.1  2546487-2546594
            386-556             JAXUCZ010000016.1  2562094-2562264
            557-619             JAXUCZ010000016.1  2566684-2566746
            620-716             JAXUCZ010000016.1  2568438-2568534
            717-793             JAXUCZ010000016.1  2568687-2568763
            794-1051            JAXUCZ010000016.1  2576216-2576473
            1052-1222           JAXUCZ010000016.1  2582072-2582242
            1223-1409           JAXUCZ010000016.1  2584906-2585092
            1410-3688           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3688
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..53
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            54..147
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1759
                     /gene="Arhgef3"
                     /note="isoform 1 is encoded by transcript variant 3; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     1"
                     /protein_id="NP_001423679.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSA
                     QDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNE
                     SRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGE
                     EDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDG
                     STEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKL
                     DLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGES
                     ECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTH
                     NEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQS
                     QTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETK
                     LEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
     misc_feature    557..1087
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    557..1087
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1127..1525
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1127..1525
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            148..214
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            215..277
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            278..385
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..556
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..619
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..716
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..793
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1051
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1222
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1409
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..3688
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgtcccc gcagtcaccg ctgcggccca gcagggccga gtcagcgggc gaggaaagaa
       61 gagctggacc tggcaagctg agtctgcaga gcatttcaca gtgatgaatc agtgcattta
      121 cagagggatg gaggagcaca aggaaagacc caagcggcca aggcagaaca acttctccat
      181 gtttccctct cccaaagcct ggaatttcag agggcggaaa cggaagcaga gtgcccagga
      241 tgaagatgcc gtcagcctat gcagtcttga cataagtgaa cctagtaaca aaagggtcaa
      301 acccctttcc agagtcacat cgctagcaaa cctcatccca cctgtgaaga ccacaccgtt
      361 aaagcgcttc agccaaacct tgcagcggtc catcagcttc cgcaatgaga gccgccccga
      421 catcctcgcc cctagagcct ggtccagaaa tgccacctcc tcaagcacga agcggaggga
      481 cagcaaactc tggagtgaga ccttcgatgt gtgtgtcagt caggtgctca cagccaagga
      541 gatcaagaga caggaggcaa tttttgagct ttctcaaggt gaagaggatt tgatagagga
      601 cttgaaatta gcaaaaaagg cctaccatga ccccatgctg aaactctcaa taatgacaga
      661 acaagagctg aatcagattt ttggaacact ggactctcta atccctctcc atgaagacct
      721 ccttagtcag cttcgagatg ttcggaagcc cgatggctcg acggaacacg ttggtcccat
      781 cctcgtgggc tggctgcctt gtctcagctc ctatgacagc tactgcagca atcaagttgc
      841 tgccaaagcc ctgctggacc acaagaagca ggaccacaga gtgcaggatt tcctccagcg
      901 ctgcttagaa tcacccttca gccgcaaact cgacctctgg aatttccttg atattccccg
      961 gagccggcta gtgaagtacc ctctgctcct tcgagaaatc ctgaggcata cgccaaacga
     1021 taatccagac cagcagcacc tggaagaagc tataaacatc attcagggaa ttgtggcaga
     1081 aatcaacacc aagactgggg aatcggaatg ccgttattac aaagagcggc ttctttactt
     1141 ggaagaaggc cagaaagatt ccctgattga cagctcaagg gtcctgtgtt gtcatggaga
     1201 gctgaaaaat aaccggggtg tgaaactcca tgttttcctg ttccaagaag tgctggtgat
     1261 tactcgagct gtcacgcaca atgagcaact ctgctatcag ttgtaccggc agcccatccc
     1321 tgtgaaggac ctcactctgg aagacctgca ggatggagaa gtgcggctgg gtggctccct
     1381 gcgtggggcc ttcagcaaca atgagagaat taaaaacttc ttcagagtca gtttcaagaa
     1441 cggatcccaa agtcagaccc actcactgca agccaacgac accttcaaca aacaacagtg
     1501 gctcaactgt atccgtcagg ccaaagaaac ggttctgtct gctgccgggc aggctggctt
     1561 gcttgactcc gagagcctgt cccagagtcc tggcactgag aacagggagc tgcggggaga
     1621 aacaaaactt gagcagatgg accaatcgga cagtgagtcg gactgcagta tggacacaag
     1681 cgaggtcagc ctcgaatgcg agcggatgga acagacagac gcttcctgtg caaacagtag
     1741 gcccgaggag aacgtctgac agaggctgtg accctgccag cagcaggccc gtgtcttacc
     1801 tgtacagtgt ttgtattcca cacgggaaca gtttggagag gcactttgta atactcctgt
     1861 gcctgtgttg gcctagcccc tgtgtctact ccttgtccct agcactgtaa ctgccaccca
     1921 gtctgtgtca gcttgcagca gcccttaccc tgttgctgta tcccacaagc atctggatga
     1981 gtgcggagga atggaccatg ttacttcgag ttgtcctaca ttcaaaacag aaagactctc
     2041 taaactactg ttgtgcatgg caaggccttt gtctcatgct tgcctagtgt tcctctagct
     2101 ctgacatagt cgctgaagtc ctggcactgg gagagctctg cagaatactg agatcgcatt
     2161 gaagggaagg cagaaagtct gattaaccct tggagggaac tccagttttg agttaattca
     2221 actagaaagc atgaaaagca tctctggggg tttctgaggt tggatttttg caaaggagga
     2281 agccttgttt tgaagcctgt ggtttcatcc agtgcaagtt gaatgtgaat aatctgtgaa
     2341 gacctgaaac agaggtggct ttagaaaggg ccaagacaag agcagctgcc ggacaggcaa
     2401 gcagaggcag gaagatgcgg agttcaagaa cagccttggc tacttaccaa attctagttc
     2461 aaactgaatt ccaccgtaaa aacaaaacaa agctaaaagc accagccagc tctgaatatt
     2521 cagctgaagt tgggggtgga tattggaggc gtttgtcatg gccaatggct tgccattaga
     2581 agagcccttt ctagcctaca acatcaggat tgccaggacc agagaagatc tgccagggtc
     2641 atgtgacccc atcagcatta tgtttcatcc tcctcagcca ctcctctttt ccagtggtaa
     2701 tagggggctg ggggataggg acacagagac tgtgactgca tccagtgact gttgacaaac
     2761 aagagagaag gacttggggg tgagaaatgt gtcactgtca cccaaggctc ctgcgtgaac
     2821 cacagaaatt gaagttactc cggagggtct caagatttcc tgctctgctt ttgggcctgg
     2881 ttctagagct acagacggac tggtggttaa ttcccctcga ggctggtttc attagctctt
     2941 attaactaga accggctagc caaactggaa agttctttgt taaagccttg ctttacagag
     3001 caaggatggg taaaaagacc ttgagggcgt ggtggaaaaa accgttcaca aactagacag
     3061 agcagcttct gcaagtgtaa atacttagag gatttgtata aaattatacc cacaccagca
     3121 ctagtagtaa tgattctaaa ttattgccaa aaagtttttt ttgtttgttg ttgttaattt
     3181 ttgcatctat caaaagttta cagaaaagaa agcaaaatgc aaagttgtcc ctttactatg
     3241 cacatgtgtc gtgcgcactg aaagaagccg tgtggcaaga gcaaccaata gaaaaacaag
     3301 gtatatgaca ttattatttt tcaagaccta ttttgaccag tttctaccct gtaaagccta
     3361 tttctgtatt tatagttttt aaccatggtg aaaatttttt tctattatga gtttatttaa
     3421 aaccattttg tctctcaagt tgctgatgta gcgaataaac ctgctccggg cagacacagt
     3481 aggaagctga gacggaccgg gcactggacg atagagaaaa gcctgaaatg ttctctacag
     3541 agccattgtg accagcgagt taaggaaggg tctctgtcag ggtcagcctg tgggaagaga
     3601 gtgaatgaat gttctggtga aatgaatact tttgtataat ggccttaaac ttttctggaa
     3661 gcatttcaaa taaattgcat taagaata
//
LOCUS       NM_001436751            3618 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 4, mRNA.
ACCESSION   NM_001436751 XM_006252576
VERSION     NM_001436751.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006252576.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.57977.1,
                                           SRR26643287.32108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000016.1  2424893-2425036
            145-207             JAXUCZ010000016.1  2454533-2454595
            208-315             JAXUCZ010000016.1  2546487-2546594
            316-486             JAXUCZ010000016.1  2562094-2562264
            487-549             JAXUCZ010000016.1  2566684-2566746
            550-646             JAXUCZ010000016.1  2568438-2568534
            647-723             JAXUCZ010000016.1  2568687-2568763
            724-981             JAXUCZ010000016.1  2576216-2576473
            982-1152            JAXUCZ010000016.1  2582072-2582242
            1153-1339           JAXUCZ010000016.1  2584906-2585092
            1340-3618           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3618
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..144
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Arhgef3"
                     /note="upstream in-frame stop codon"
     CDS             94..1689
                     /gene="Arhgef3"
                     /note="isoform 2 is encoded by transcript variant 4; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     2"
                     /protein_id="NP_001423680.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MRSERPMVWCCFFLRAQRKRKQSAQDEDAVSLCSLDISEPSNKR
                     VKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNESRPDILAPRAWSRNATSSST
                     KRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLK
                     LSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD
                     SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLL
                     REILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL
                     IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTL
                     EDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCI
                     RQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQMDQSDSESDCSMDTSEV
                     SLECERMEQTDASCANSRPEENV"
     misc_feature    487..1017
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    487..1017
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1057..1455
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1057..1455
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            145..207
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..315
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..486
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..549
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..646
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            647..723
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..981
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1152
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1339
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..3618
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggagttc cctcagggaa accatgctca cacagctcag agcgccctgt ccactaggct
       61 tttctgcggt tagcagccag ggagttgggg tggatgaggt cggagcgtcc catggtgtgg
      121 tgctgtttct ttctccgtgc acagcggaaa cggaagcaga gtgcccagga tgaagatgcc
      181 gtcagcctat gcagtcttga cataagtgaa cctagtaaca aaagggtcaa acccctttcc
      241 agagtcacat cgctagcaaa cctcatccca cctgtgaaga ccacaccgtt aaagcgcttc
      301 agccaaacct tgcagcggtc catcagcttc cgcaatgaga gccgccccga catcctcgcc
      361 cctagagcct ggtccagaaa tgccacctcc tcaagcacga agcggaggga cagcaaactc
      421 tggagtgaga ccttcgatgt gtgtgtcagt caggtgctca cagccaagga gatcaagaga
      481 caggaggcaa tttttgagct ttctcaaggt gaagaggatt tgatagagga cttgaaatta
      541 gcaaaaaagg cctaccatga ccccatgctg aaactctcaa taatgacaga acaagagctg
      601 aatcagattt ttggaacact ggactctcta atccctctcc atgaagacct ccttagtcag
      661 cttcgagatg ttcggaagcc cgatggctcg acggaacacg ttggtcccat cctcgtgggc
      721 tggctgcctt gtctcagctc ctatgacagc tactgcagca atcaagttgc tgccaaagcc
      781 ctgctggacc acaagaagca ggaccacaga gtgcaggatt tcctccagcg ctgcttagaa
      841 tcacccttca gccgcaaact cgacctctgg aatttccttg atattccccg gagccggcta
      901 gtgaagtacc ctctgctcct tcgagaaatc ctgaggcata cgccaaacga taatccagac
      961 cagcagcacc tggaagaagc tataaacatc attcagggaa ttgtggcaga aatcaacacc
     1021 aagactgggg aatcggaatg ccgttattac aaagagcggc ttctttactt ggaagaaggc
     1081 cagaaagatt ccctgattga cagctcaagg gtcctgtgtt gtcatggaga gctgaaaaat
     1141 aaccggggtg tgaaactcca tgttttcctg ttccaagaag tgctggtgat tactcgagct
     1201 gtcacgcaca atgagcaact ctgctatcag ttgtaccggc agcccatccc tgtgaaggac
     1261 ctcactctgg aagacctgca ggatggagaa gtgcggctgg gtggctccct gcgtggggcc
     1321 ttcagcaaca atgagagaat taaaaacttc ttcagagtca gtttcaagaa cggatcccaa
     1381 agtcagaccc actcactgca agccaacgac accttcaaca aacaacagtg gctcaactgt
     1441 atccgtcagg ccaaagaaac ggttctgtct gctgccgggc aggctggctt gcttgactcc
     1501 gagagcctgt cccagagtcc tggcactgag aacagggagc tgcggggaga aacaaaactt
     1561 gagcagatgg accaatcgga cagtgagtcg gactgcagta tggacacaag cgaggtcagc
     1621 ctcgaatgcg agcggatgga acagacagac gcttcctgtg caaacagtag gcccgaggag
     1681 aacgtctgac agaggctgtg accctgccag cagcaggccc gtgtcttacc tgtacagtgt
     1741 ttgtattcca cacgggaaca gtttggagag gcactttgta atactcctgt gcctgtgttg
     1801 gcctagcccc tgtgtctact ccttgtccct agcactgtaa ctgccaccca gtctgtgtca
     1861 gcttgcagca gcccttaccc tgttgctgta tcccacaagc atctggatga gtgcggagga
     1921 atggaccatg ttacttcgag ttgtcctaca ttcaaaacag aaagactctc taaactactg
     1981 ttgtgcatgg caaggccttt gtctcatgct tgcctagtgt tcctctagct ctgacatagt
     2041 cgctgaagtc ctggcactgg gagagctctg cagaatactg agatcgcatt gaagggaagg
     2101 cagaaagtct gattaaccct tggagggaac tccagttttg agttaattca actagaaagc
     2161 atgaaaagca tctctggggg tttctgaggt tggatttttg caaaggagga agccttgttt
     2221 tgaagcctgt ggtttcatcc agtgcaagtt gaatgtgaat aatctgtgaa gacctgaaac
     2281 agaggtggct ttagaaaggg ccaagacaag agcagctgcc ggacaggcaa gcagaggcag
     2341 gaagatgcgg agttcaagaa cagccttggc tacttaccaa attctagttc aaactgaatt
     2401 ccaccgtaaa aacaaaacaa agctaaaagc accagccagc tctgaatatt cagctgaagt
     2461 tgggggtgga tattggaggc gtttgtcatg gccaatggct tgccattaga agagcccttt
     2521 ctagcctaca acatcaggat tgccaggacc agagaagatc tgccagggtc atgtgacccc
     2581 atcagcatta tgtttcatcc tcctcagcca ctcctctttt ccagtggtaa tagggggctg
     2641 ggggataggg acacagagac tgtgactgca tccagtgact gttgacaaac aagagagaag
     2701 gacttggggg tgagaaatgt gtcactgtca cccaaggctc ctgcgtgaac cacagaaatt
     2761 gaagttactc cggagggtct caagatttcc tgctctgctt ttgggcctgg ttctagagct
     2821 acagacggac tggtggttaa ttcccctcga ggctggtttc attagctctt attaactaga
     2881 accggctagc caaactggaa agttctttgt taaagccttg ctttacagag caaggatggg
     2941 taaaaagacc ttgagggcgt ggtggaaaaa accgttcaca aactagacag agcagcttct
     3001 gcaagtgtaa atacttagag gatttgtata aaattatacc cacaccagca ctagtagtaa
     3061 tgattctaaa ttattgccaa aaagtttttt ttgtttgttg ttgttaattt ttgcatctat
     3121 caaaagttta cagaaaagaa agcaaaatgc aaagttgtcc ctttactatg cacatgtgtc
     3181 gtgcgcactg aaagaagccg tgtggcaaga gcaaccaata gaaaaacaag gtatatgaca
     3241 ttattatttt tcaagaccta ttttgaccag tttctaccct gtaaagccta tttctgtatt
     3301 tatagttttt aaccatggtg aaaatttttt tctattatga gtttatttaa aaccattttg
     3361 tctctcaagt tgctgatgta gcgaataaac ctgctccggg cagacacagt aggaagctga
     3421 gacggaccgg gcactggacg atagagaaaa gcctgaaatg ttctctacag agccattgtg
     3481 accagcgagt taaggaaggg tctctgtcag ggtcagcctg tgggaagaga gtgaatgaat
     3541 gttctggtga aatgaatact tttgtataat ggccttaaac ttttctggaa gcatttcaaa
     3601 taaattgcat taagaata
//
LOCUS       NM_001005903            1643 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 6, mRNA.
ACCESSION   NM_001005903 XM_216562
VERSION     NM_001005903.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1643)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1643)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1643)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1643)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1643)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1643)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001005903.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083861.1, SRR26360181.1180647.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  156718904-156719005
            103-192             JAXUCZ010000005.1  156766717-156766806
            193-314             JAXUCZ010000005.1  156784207-156784328
            315-428             JAXUCZ010000005.1  156788909-156789022
            429-570             JAXUCZ010000005.1  156806838-156806979
            571-687             JAXUCZ010000005.1  156807266-156807382
            688-753             JAXUCZ010000005.1  156813995-156814060
            754-830             JAXUCZ010000005.1  156814589-156814665
            831-1643            JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1643
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..102
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..918
                     /gene="Capzb"
                     /note="isoform 6 is encoded by transcript variant 6;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 6"
                     /protein_id="NP_001005903.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVD
                     QPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANN
                     AFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKS
                     SGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE
                     DMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC"
     misc_feature    103..105
                     /gene="Capzb"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P47756; propagated from
                     UniProtKB/Swiss-Prot (Q5XI32.1); acetylation site"
     misc_feature    103..105
                     /gene="Capzb"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XI32.1); phosphorylation site"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    802..804
                     /gene="Capzb"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P47756; propagated from
                     UniProtKB/Swiss-Prot (Q5XI32.1); acetylation site"
     exon            103..192
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            193..314
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            315..428
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            429..570
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            571..687
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            688..753
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            754..830
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1643
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcactctt gggcacccgg ggaagtggaa gcgccgggcc ctgctgcggg ggggagagcc
       61 acagacgccg ggactgggac cgtcgccgcc gccgccacca tgagcgatca gcagctggac
      121 tgcgccttgg acctgatgag gcgcctgcct ccacagcaga ttgagaaaaa cctcagcgat
      181 ctgatcgacc tggtccccag tctgtgtgaa gatctcctgt cttctgttga ccagcccctg
      241 aaaattgcca gagacaaggt ggtgggcaag gactaccttt tgtgtgacta caacagagac
      301 ggggactcct ataggtcacc atggagtaac aagtatgacc ctcctttgga agatggggcc
      361 atgccatctg ctcggctcag aaagctggag gtagaggcca acaatgcctt cgaccaatac
      421 cgagacctgt attttgaagg tggtgtctca tcagtctacc tctgggatct cgatcatggc
      481 tttgctggag tgatcctcat aaagaaggct ggggatggat caaagaagat caaaggctgc
      541 tgggattcca tccacgtggt ggaagtgcag gagaagtcca gtggccgtac tgcccattac
      601 aagttgacct ccacagtgat gctatggctg caaaccaaca aatccggctc aggcaccatg
      661 aacctgggag gcagcctaac cagacagatg gagaaggacg aaactgtgag tgactgttcc
      721 ccacacatag ccaacattgg gcgcctggtg gaggacatgg aaaacaaaat cagaagcacg
      781 ctgaatgaga tctactttgg aaaaacaaag gacatcgtca acgggctgag gtctgtgcag
      841 acgtttgcag acaaatcaaa gcaggaagcc cttaagaatg acctggtgga agccttgaag
      901 agaaagcagc agtgttaaag acctgcttca cgctaaccgg acacgccatg cactcgttag
      961 gttcctttct ttagaaaact cgttttctgc tccttttccc tcttcctttc cctccctgac
     1021 ggtcacataa cagtttgcat cgaccacgca gcgccatctc tcccccaaaa taaagtccaa
     1081 taaccaccct ctggctccaa ggcctgcttc ccacgacgtt tccatagaga ccgtgtggct
     1141 ttgttcgcct gtccccttcc ttcccttgcc cgtttgtagg cacaggcgca ctgtctgaca
     1201 tcctccctcc gtctttttgt tacattggtg taaaaaatgt aaaacaaaaa aattttatga
     1261 actaactggt gtgtgaaaga agggaaactg gagctctgat ccgtgtgtgt ttgggggttg
     1321 cttggagccg ggggccgggg gacaggggac agctatggag gaaggagaca tgtcctcagc
     1381 actgtcctgc gcagagcagg tgtgcccttg tcccaaggag accgcggtgg gggtgggggc
     1441 ggggctggcg accgctgctc tctggccagg tgcttttctg tcaaattttt atggaatgca
     1501 aaaggagttt tttgttttat tttgtttttt gtaaagctta aacagacaaa aaaaatctac
     1561 atcttctact tgagcctcca tacttaaaaa aaaaaaagga aaaaaagaac aaaaaaaata
     1621 aataaaaaga aactgggaca caa
//
LOCUS       NM_001436742            3348 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transketolase (Tkt), transcript variant 2, mRNA.
ACCESSION   NM_001436742
VERSION     NM_001436742.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Zhao,Y., Wu,Y., Hu,H., Cai,J., Ning,M., Ni,X. and Zhong,C.
  TITLE     Downregulation of transketolase activity is related to inhibition
            of hippocampal progenitor cell proliferation induced by thiamine
            deficiency
  JOURNAL   Biomed Res Int 2014, 572915 (2014)
   PUBMED   25028661
  REMARK    GeneRIF: results suggest that modulation of transketolase activity
            might be one of the mechanisms by which thiamine regulates the
            proliferation of hippocampal progenitor cells.
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Mitschke,L., Parthier,C., Schroder-Tittmann,K., Coy,J., Ludtke,S.
            and Tittmann,K.
  TITLE     The crystal structure of human transketolase and new insights into
            its mode of action
  JOURNAL   J Biol Chem 285 (41), 31559-31570 (2010)
   PUBMED   20667822
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Wang,J.J., Martin,P.R. and Singleton,C.K.
  TITLE     Aspartate 155 of human transketolase is essential for thiamine
            diphosphate-magnesium binding, and cofactor binding is required for
            dimer formation
  JOURNAL   Biochim Biophys Acta 1341 (2), 165-172 (1997)
   PUBMED   9357955
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   McCool,B.A., Plonk,S.G., Martin,P.R. and Singleton,C.K.
  TITLE     Cloning of human transketolase cDNAs and comparison of the
            nucleotide sequence of the coding region in Wernicke-Korsakoff and
            non-Wernicke-Korsakoff individuals
  JOURNAL   J Biol Chem 268 (2), 1397-1404 (1993)
   PUBMED   8419340
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Abedinia,M., Layfield,R., Jones,S.M., Nixon,P.F. and Mattick,J.S.
  TITLE     Nucleotide and predicted amino acid sequence of a cDNA clone
            encoding part of human transketolase
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1159-1166 (1992)
   PUBMED   1567394
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   10 (bases 1 to 3348)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.34986.1,
                                           SRR26643299.58027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000016.1  5730875-5731064
            191-232             JAXUCZ010000016.1  5739361-5739402
            233-350             JAXUCZ010000016.1  5740422-5740539
            351-464             JAXUCZ010000016.1  5741405-5741518
            465-562             JAXUCZ010000016.1  5742133-5742230
            563-754             JAXUCZ010000016.1  5747104-5747295
            755-873             JAXUCZ010000016.1  5748625-5748743
            874-1067            JAXUCZ010000016.1  5749659-5749852
            1068-1232           JAXUCZ010000016.1  5750484-5750648
            1233-1389           JAXUCZ010000016.1  5751274-5751430
            1390-1520           JAXUCZ010000016.1  5751544-5751674
            1521-1604           JAXUCZ010000016.1  5752336-5752419
            1605-1698           JAXUCZ010000016.1  5752527-5752620
            1699-1821           JAXUCZ010000016.1  5753474-5753596
            1822-3348           JAXUCZ010000016.1  5754882-5756408
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3348
                     /gene="Tkt"
                     /note="transketolase"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
     exon            1..190
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            191..232
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    231..233
                     /gene="Tkt"
                     /note="upstream in-frame stop codon"
     exon            233..350
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1997
                     /gene="Tkt"
                     /EC_number="2.2.1.1"
                     /note="isoform 2 is encoded by transcript variant 2; TK"
                     /codon_start=1
                     /product="transketolase isoform 2"
                     /protein_id="NP_001423671.1"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
                     /translation="MAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGF
                     LPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRV
                     YCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDVYQKRCE
                     AFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKN
                     MAEQIIQEIYSQVQSKKKILATPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYGL
                     ALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDR
                     TVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRS
                     VPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLK
                     SKDDQVTVIGAGVTLHEALAAAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGR
                     ILTVEDHYYEGGIGEAVSAAVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIV
                     QAVKGLVTKG"
     misc_feature    267..1985
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    267..1985
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     exon            351..464
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            465..562
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            563..754
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            755..873
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1067
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1232
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1389
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1520
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1604
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1698
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1821
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..3348
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggtcact gccggtcgct tcctgagcct cctctggctc tgtgtctctg tcctcagctt
       61 ccacgtcctc gcccgaccgc gccatggagg gttaccataa gccagatcag cagaagctcc
      121 aggccctgaa ggacacagcc aatcgcctgc gcatcagctc catccaggcc accaccgcgg
      181 caggctcggg gtgtagtgtc ttttccccca tgaccaggag ttcatagaga tgacacccca
      241 catcatgctg cagcgctgcc gagatcatgg ctgtcctgtt tttccatacc atgcgctaca
      301 aggccctgga tccccgaaac cctcacaatg atcgctttgt gctctccaag ggccatgcag
      361 ctcccatctt atatgcagtc tgggctgaag ctggcttcct gcctgaggca gagctgctga
      421 acctgaggaa aatcagctct gacttggatg ggcatcctgt cccgaaacaa gccttcaccg
      481 atgtggccac tggctccctg ggccaggggc tgggagctgc gtgcgggatg gcatacacag
      541 gcaaatactt cgacaaagcc agctaccgag tctattgcat gctgggagac ggggaggtgt
      601 ccgagggctc cgtttgggag gccatggcct tcgctggaat ttacaagctg gacaacctcg
      661 ttgccatttt tgacatcaac cgtctgggcc agagcgaccc agccccgctg cagcaccaag
      721 tggacgtcta ccagaagcgc tgtgaggcct ttggctggca tgccatcatc gtggatgggc
      781 acagtgtgga ggagctgtgc aaggcctttg gtcaggccaa gcaccaacca acagccatca
      841 ttgccaagac cttcaagggc cgcgggatca cagggattga agacaaggag gcgtggcatg
      901 ggaagcccct ccccaaaaac atggctgagc agattatcca ggagatttac agccaggttc
      961 agagcaaaaa gaagatcctc gccacgcccc ctcaggagga tgccccttcc gtggacattg
     1021 ccaacatccg aatgcctacc ccacccaact acaaagtggg ggacaagata gccacacgga
     1081 aagcctatgg attggccctt gccaagctgg gccacgccag tgaccgcatc atcgccctgg
     1141 atggagacac caaaaattcc accttctcag agctcttcaa aaaggagcac ccagaccgtt
     1201 tcatcgagtg ctacattgct gagcagaaca tggtgagcat tgctgtgggc tgtgccacac
     1261 gtgacaggac agtgcccttc tgcagcactt ttgcggcctt cttcacacgc gccttcgacc
     1321 agatccgcat ggccgccatc tccgagagca acatcaacct ctgtggctcc cattgcggcg
     1381 tgtccattgg ggaagacggg ccctcgcaga tggccctgga agacctggcc atgtttcggt
     1441 cggtccctat gtccaccgtc ttttacccaa gtgatggagt tgccacagag aaggcagtgg
     1501 aattagcagc caatacaaag ggcatctgct tcattcggac cagccgccca gaaaatgcca
     1561 ttatctatag caacaacgag gatttccagg ttggccaagc caaggtggtc ctgaagagca
     1621 aggacgacca agtgacggtg atcggggctg gcgtaactct gcacgaggct ctggctgctg
     1681 cagagatgtt gaagaaagag aagatcggcg tccgtgtact ggaccccttc accatcaagc
     1741 ccctggacaa aaagctcatt ctcgactgtg ccagagcaac caaaggcagg atcctcaccg
     1801 tggaggacca ctactatgaa ggtggcatag gcgaggcagt atctgctgcg gtagtgggcg
     1861 aacctggagt cacagtcact cgcctggcgg tcagccaagt accacgaagt gggaagccag
     1921 ctgagctgct gaagatgttt ggtattgaca aagacgccat tgtgcaagct gtgaagggcc
     1981 ttgtcaccaa gggctaggaa ggacatggga tgccgggtgg gtgaactaca cattccaggg
     2041 atgttctggc aaaggtgctc aagggtgtac cgagtggaaa ggtaaatata tgttttgaga
     2101 aaaaaattaa tcctgactgt tttctttgat atgaacatat ccagtatagg aagggagaaa
     2161 ggaagagagc tggctgtcta gacttggggg ggtcaggatc taaggtgtac cctgggatcc
     2221 ccttctccag ttcagcctct gcaaagccag aactactacc cactgtagcc tgccttttag
     2281 ccagatagga tccagcccct tttctcacca ctgtacccta aaggactgtg gagttctccc
     2341 tgccttataa aactttcctg atccttctta gccgcctcat gccccccaag gtcccgcaag
     2401 gcttcctttt ataggtggcc cactggtaag cttcctagga attcctcagt gtccgtaggg
     2461 aagatgaggc ccatttgtgg aactaggcac atgtctgctc cttgaaaccg gagctgttca
     2521 gctggtgagc tgcctggcca gatccttccg tgccagggaa ctgaatggta ccaactccag
     2581 aaacagcaga taaggtaggt ctcagggaga agacggtgat tcctcagtgg gtggtcttag
     2641 ggcaaaccct gggagaaact ctccttcact gagaaaagaa ggcaagtcat cgccctgtgg
     2701 ggacagctga ggaacttccc agtcaagagt ttggagtttg gacataatta caatgtattt
     2761 tcttatgtag tccataacaa caaaagggta aagcagaaaa tcagggattc ggggtgcttg
     2821 ggcaccacct ggtggccatc tctggtacta cagtgctaaa cacaccccac agcaatctgt
     2881 ggaaggtgct gttttctgag atctgggaag caactgctcg cagaaggaga tggaggtgcc
     2941 cgtgacagtg ctgaatgaac ttcgtatgca ttttatttga tccttactcc aagataccat
     3001 tttagaagat attcctcttg gcccagtgct gaggattggt ctgttgcttt gtatcgtaac
     3061 atcaaatact gtacctgaag gtctaaaagc ttttgttgtg caaaccttcc ttaatctaac
     3121 actattgttt aaataaaaat gactacagtc aattactgga gggattagag gtaggccgct
     3181 tttgagtttc ctggttgggg gttgcggagg gaggagaggt gagagaagga agccaccaca
     3241 ggaggaggtg accatgaaca agtattgggt actctgccgg ggaagtagca agtccagcag
     3301 acaggaaagt agattaggga ttacctccag taattgtcaa taaaacaa
//
LOCUS       NM_001436759            3293 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 4, mRNA.
ACCESSION   NM_001436759 XM_039109758
VERSION     NM_001436759.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_039109758.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.197266.1,
                                           SRR26360172.2658382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-943               JAXUCZ010000005.1  21321202-21322144   c
            944-1030            JAXUCZ010000005.1  21318760-21318846   c
            1031-1419           JAXUCZ010000005.1  21316424-21316812   c
            1420-1584           JAXUCZ010000005.1  21304734-21304898   c
            1585-1778           JAXUCZ010000005.1  21301659-21301852   c
            1779-1839           JAXUCZ010000005.1  21296573-21296633   c
            1840-1979           JAXUCZ010000005.1  21294405-21294544   c
            1980-3293           JAXUCZ010000005.1  21291897-21293210   c
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3293
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..943
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    879..881
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="upstream in-frame stop codon"
     exon            944..1030
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1419
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             1095..2084
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform a is encoded by transcript variant 4;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform a"
                     /protein_id="NP_001423688.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAN"
     misc_feature    1401..2021
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    1401..2021
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(1479..1481,1488..1490,1497..1499,1542..1553,
                     1686..1694)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(1479..1481,1488..1490,1497..1499,1542..1553,
                     1686..1694)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            1420..1584
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1778
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1839
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1979
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..3293
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcatcc gcaactctct cggctctcgg aacggaccgc cgcagctttt tgtctgaggc
       61 taggcgtatc tcttgtctca tgacggtcca gtcccgcgag cctgatggag ctggagggaa
      121 aagtgagacc ctagtgccga ggccattggt acaggttaga actgttggtg agctgactga
      181 gcagggttgg aatgctggtt tatgctcttt agtacccatg tgacttttgg caagccactt
      241 ggcctctagg agcagcgtct gactacttat aaaaaagggt tgaatagcaa taattatccc
      301 acgaggctcc ggagaggatc caaggaaaca gcacttacaa acttttatat ttgtgcaaat
      361 tcgacttggt ccagatcctg tagatgctgc gctgccgcga tcgctgggtt ttgtaatcag
      421 ttaaacattt gtaagaaata atatgcgtaa gttgaacata gaaaacttac agaatttcta
      481 tatttggggg aaaaagacat tcagcactag gtgctgtttg agactggcca acagcttcct
      541 caaaaactaa ataagctcat gtttgaaggt ttttgcatca tcgaagactt agtttgtgtt
      601 tattggtact ttttatgggc tgtataagaa ctgagctgat atttgtattt ggaccacgtt
      661 tgtgaatcga tgggaatact ttaattttta aagaaaatgt ttttccctac attcttgatg
      721 cggcttgatt ttgaggtcaa gtatattttg aacttaggag ttatgaagga aagagtactg
      781 catttgtaga tacaccagtc tagatgtgga ttataggtag gtatggcggc atacaccttt
      841 aatctcagac ttgggaggca gaggcagaca aatctttttg agatcaaggc caccttaatc
      901 tgccaagcaa gtcaggtcca cacagatcct gtctgaaaaa taagttcacc cccgctgcag
      961 cagggctctg ctctctgact gagtggtgct gtgttacatg gatctgtcat ttctattcag
     1021 tcatcagttg gcattgcagt aacacctatg gcaatgaaga aagagacaga atttgggatt
     1081 ttcatctaag gaaaatgata aataacaacc agacgtgtgc tgcagggcag gactccgtgc
     1141 cctacgtgac ctgtatgctt cacgtgctgg aagagtggtt gggtgtggaa cagttggagg
     1201 actacctgaa ttttgcgaac catctcttgt gggtcttcac cccgctgatc cttttaatac
     1261 ttccgtactt taccatcttc cttctctacc ttactattat tttcctccac atctataaga
     1321 ggaagaatgt gttaaaagaa gcctactctc acaacttgtg ggatggcgcg aggaaaacag
     1381 tggcaaccct gtgggatgga catgcggcgg tttggcatgg ttatgaagtt cacgggatgg
     1441 aaaagatacc agaaggacca gcacttataa ttttttatca tggagctatt cccatagact
     1501 tttactactt catggctaaa attttcatcc acaaaggcag aacttgccga gtggtagctg
     1561 accactttgt ctttaaaatc ccagggttca gtttattact tgatgtattt tgtgctcttc
     1621 atggaccaag agaaaaatgt gttgaaatct tgaggagtgg tcacttgtta gctatttcac
     1681 cgggtggagt tcgagaagcc ttacttagtg atgaaaccta caacatcata tggggtaatc
     1741 gtaaaggctt tgctcaggtt gcaatcgatg caaaagtgcc cattattcct atgtttacac
     1801 aaaacatccg agaaggattt agatcactcg gaggaacaag attgtttaaa tggctttatg
     1861 aaaaattccg ctatccgttt gctccaatgt atggaggttt tcctgtgaag ttgcggacct
     1921 tcttgggtga tcctattccg tatgacccag aggtaacagc agaagaatta gctgaaaaga
     1981 ctaagaacgc tgttcaagct ttgatcgaca agcaccaaag gataccgggg aacattagga
     2041 gtgctttgct ggaccgcttt cataaagagc agaaggctaa ttgacagata atttcgtgtg
     2101 tctctaatgc caagtttgca tctgtggtac tgccttttaa acttttgtag gttgtataat
     2161 agtcttttta aaacctgcta atgagcatct ttctttagaa tttaaacttt ctatggttaa
     2221 tcttaccctt tcaatcagtt ttgtcaaatg tagtaagtaa ctcaccattt gcttgactca
     2281 gaagatgatc atgttgcatt tgcaatcctt agtagtatat gataggcaca agtcttcctg
     2341 gataccagca gtctaggtta ggcagacttc actaaattat gcttctgtgt ttgtgtctgt
     2401 tgtgccaatg ggatggtgag aggtacctga gctggggtgt agcacttgct tagtttaggt
     2461 gagcggtgcc tttgtatcca tccttcattc cactcacaac tgctggtaag ttgtgaaacg
     2521 cttttgcacc tccgtggttt atgttaagca tggtaatact gtggtggtga acattaagtt
     2581 gcttatgtct actgtgatat atccgtatct atatatctga tagatatctg tagtgagaaa
     2641 tctgtaattg aattgattcc tgaatccttt aggagttatg tacatttttg tttattgggt
     2701 attgaaatta ctccttcagg gatgatgtcc agttgccaag cacaatgaaa gagatgtact
     2761 attttgtaaa tcaaatcatt gttatttgta gtatttatta acagagttgt ttggtattta
     2821 ttttaaacaa ggatctaagt aaatgtatag gatggattgt cagcacgtgt cttacacggt
     2881 gtaaagataa aatcgtgggc acgctctgca gtttatgtta gagcagatcc taggctgagg
     2941 agtgacaact gaggaagctc tgcctcgctt gtcccagggc tcgcttccgt gctctgcagc
     3001 cagtcacgtg gttatatctg taaaatgtac ttgaatgatg aatttctgta aacatggagt
     3061 cctctgaaaa tgtaattact ttgaattgtt gtcttcttga aaacttattt taaaagtatt
     3121 taaacagcca agtatcatga attcatcgca gtgtgtcttc cccctttgca gtacttgggt
     3181 tttatatgga ctttttaact acaagtgtat atttgtgata tgtataatgt atgtataatg
     3241 tatatagaaa tggtgtgaaa ataaagctga actgcaactc ctctctagta aaa
//
LOCUS       NM_001436756            1132 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus occludin/ELL domain containing 1 (Ocel1),
            transcript variant 3, mRNA.
ACCESSION   NM_001436756
VERSION     NM_001436756.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.84895.1,
                                           SRR26360186.322549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               JAXUCZ010000016.1  18077314-18077991
            679-844             JAXUCZ010000016.1  18078324-18078489
            845-895             JAXUCZ010000016.1  18078610-18078660
            896-1132            JAXUCZ010000016.1  18078828-18079064
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1132
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /note="occludin/ELL domain containing 1"
                     /db_xref="GeneID:290628"
                     /db_xref="RGD:1565407"
     exon            1..678
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    257..259
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /note="upstream in-frame stop codon"
     CDS             347..1024
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /note="isoform 3 is encoded by transcript variant 3;
                     occludin/ELL domain-containing protein 1"
                     /codon_start=1
                     /product="occludin/ELL domain-containing protein 1 isoform
                     3"
                     /protein_id="NP_001423685.1"
                     /db_xref="GeneID:290628"
                     /db_xref="RGD:1565407"
                     /translation="MQIPAGPSSRRRSRGPLACGSQSRRSGPDATCNSRPAAGGRQSA
                     TAPCMPARERPQPRAGRPHCQPRPSELRTRPRKIVFADELQPRAPLHPEKHPRDLGPR
                     PNPVPDYELKYPPVTSRRDRSRYAAVFQDQYEEFLELQRQVGAMQAKLQQLEALLLSL
                     PPPRSQEVRMAAHVRREFEKKRVDPGFLDKQARCDYLKGKLRHLKAQIRKFDDQRDSN
                     SENSVYF"
     misc_feature    683..985
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /note="Occludin homology domain; Region: Occludin_ELL;
                     pfam07303"
                     /db_xref="CDD:462140"
     misc_feature    683..985
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /note="Occludin homology domain; Region: Occludin_ELL;
                     pfam07303"
                     /db_xref="CDD:462140"
     exon            679..844
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /inference="alignment:Splign:2.1.0"
     exon            845..895
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1132
                     /gene="Ocel1"
                     /gene_synonym="RGD1563236; RGD1565407"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcctgca cagctgcgct cccggcggca gagccagggg cagctccggg acaggtgaca
       61 ccgagcggaa ccatcggata accacaggcg ggcaggggcc gggagctccg cgggccgaaa
      121 ccccgcgagg caggaggcag ggaggcggtt tcgactcggc ccagggtcga cctccgcggc
      181 tttgcgcttt tccggtttca aggatggggc ggggcctgcg gtgcaccgtc agccactctg
      241 gtgcgtgacg gcacggtgac gccacggcgc ctcttccacg cccctttccg gggtccgcac
      301 cgtgggacag aatctgggtt gcgcggccag ccaaccgcgc tcgcgtatgc aaatacccgc
      361 aggcccctcc tccaggcgcc gctcacgcgg tcctctggcc tgcggatccc agtccaggcg
      421 ctcaggccct gatgccactt gcaattcgcg ccctgccgcc gggggtcgcc agagcgctac
      481 ggcaccatgc atgcctgccc gggagcgtcc gcagccccgc gccggacggc cgcactgcca
      541 gcccaggccc agtgagctcc gcacgaggcc ccggaagatc gtgtttgcgg atgagctgca
      601 accccgggcc ccactgcacc cagagaagca tcccagggat ctgggacccc gccccaaccc
      661 agtgcctgac tacgagctta agtacccacc agtgaccagc agaagggacc gaagccgcta
      721 tgccgcagtg tttcaggacc agtacgaaga gttcttggag ctccagcggc aggtgggggc
      781 catgcaggct aagctccagc aactggaggc tctgctgctg tcactgcccc cgccgcgaag
      841 ccaggaggtt cgcatggcag ctcatgtcag aagagagttt gagaagaagc gggtggatcc
      901 tggtttcctg gataagcaag ctcgctgtga ctacctgaag ggtaaactga ggcacctcaa
      961 ggcccagatc cgcaaatttg atgaccaaag ggacagcaac agtgagaact ccgtgtactt
     1021 ctgagtgtct tagacatggt ggtcggctcc tcttcccacg gggaaccaca ccagttcttc
     1081 ccgggaaagc aagtcctgtt gagaatccca gagaataaac atggaataga ca
//
LOCUS       NM_001436753            4003 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 7, mRNA.
ACCESSION   NM_001436753
VERSION     NM_001436753.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4003)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2429703.1,
                                           SRR26643297.46193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               JAXUCZ010000016.1  2308404-2308838
            436-529             JAXUCZ010000016.1  2343846-2343939
            530-592             JAXUCZ010000016.1  2454533-2454595
            593-700             JAXUCZ010000016.1  2546487-2546594
            701-871             JAXUCZ010000016.1  2562094-2562264
            872-934             JAXUCZ010000016.1  2566684-2566746
            935-1031            JAXUCZ010000016.1  2568438-2568534
            1032-1108           JAXUCZ010000016.1  2568687-2568763
            1109-1366           JAXUCZ010000016.1  2576216-2576473
            1367-1537           JAXUCZ010000016.1  2582072-2582242
            1538-1724           JAXUCZ010000016.1  2584906-2585092
            1725-4003           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..4003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..4003
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..435
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..529
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    461..463
                     /gene="Arhgef3"
                     /note="upstream in-frame stop codon"
     exon            530..592
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..700
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..871
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..934
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1031
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             950..2074
                     /gene="Arhgef3"
                     /note="isoform 4 is encoded by transcript variant 7; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     4"
                     /protein_id="NP_001423682.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTE
                     HVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLW
                     NFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECR
                     YYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQ
                     LCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTH
                     SLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETKLEQ
                     MDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
     misc_feature    968..1402
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    968..1402
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1442..1840
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1442..1840
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            1032..1108
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1366
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1537
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1724
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..4003
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgtcccc gcagtcaccg ctgcggccca gcagggccga gtcagcgggc gaggtaagag
       61 ccgcaggaac atcgcgtcgc ctgatcgtcc ttttacccgc tgcccctacc agagaagagt
      121 ccccatggcc actctgtggc gcgttggata gacagtgcca ctgcctgctt ctgcccgcgt
      181 ccgctcctgc cggggacccc aacttcggtc ctccgatagc tcctgggaga aagttcctgg
      241 agccacttcc gggagggagg cgccacctgt ctggggcgcg ccctgacgct ggacttgtcc
      301 aggtcagtgt ctttggtcac ttggccggga cgcgggtacc accaccgtca gccaggatcc
      361 ttactccgga gaccgcgtct tttaaactgc gcagcggaca gtcttgagat gggaggcgcc
      421 cgcccagagc tgaaggaaag aagagctgga cctggcaagc tgagtctgca gagcatttca
      481 cagtgatgaa tcagtgcatt tacagaggga tggaggagca caaggaaagc ggaaacggaa
      541 gcagagtgcc caggatgaag atgccgtcag cctatgcagt cttgacataa gtgaacctag
      601 taacaaaagg gtcaaacccc tttccagagt cacatcgcta gcaaacctca tcccacctgt
      661 gaagaccaca ccgttaaagc gcttcagcca aaccttgcag cggtccatca gcttccgcaa
      721 tgagagccgc cccgacatcc tcgcccctag agcctggtcc agaaatgcca cctcctcaag
      781 cacgaagcgg agggacagca aactctggag tgagaccttc gatgtgtgtg tcagtcaggt
      841 gctcacagcc aaggagatca agagacagga ggcaattttt gagctttctc aaggtgaaga
      901 ggatttgata gaggacttga aattagcaaa aaaggcctac catgacccca tgctgaaact
      961 ctcaataatg acagaacaag agctgaatca gatttttgga acactggact ctctaatccc
     1021 tctccatgaa gacctcctta gtcagcttcg agatgttcgg aagcccgatg gctcgacgga
     1081 acacgttggt cccatcctcg tgggctggct gccttgtctc agctcctatg acagctactg
     1141 cagcaatcaa gttgctgcca aagccctgct ggaccacaag aagcaggacc acagagtgca
     1201 ggatttcctc cagcgctgct tagaatcacc cttcagccgc aaactcgacc tctggaattt
     1261 ccttgatatt ccccggagcc ggctagtgaa gtaccctctg ctccttcgag aaatcctgag
     1321 gcatacgcca aacgataatc cagaccagca gcacctggaa gaagctataa acatcattca
     1381 gggaattgtg gcagaaatca acaccaagac tggggaatcg gaatgccgtt attacaaaga
     1441 gcggcttctt tacttggaag aaggccagaa agattccctg attgacagct caagggtcct
     1501 gtgttgtcat ggagagctga aaaataaccg gggtgtgaaa ctccatgttt tcctgttcca
     1561 agaagtgctg gtgattactc gagctgtcac gcacaatgag caactctgct atcagttgta
     1621 ccggcagccc atccctgtga aggacctcac tctggaagac ctgcaggatg gagaagtgcg
     1681 gctgggtggc tccctgcgtg gggccttcag caacaatgag agaattaaaa acttcttcag
     1741 agtcagtttc aagaacggat cccaaagtca gacccactca ctgcaagcca acgacacctt
     1801 caacaaacaa cagtggctca actgtatccg tcaggccaaa gaaacggttc tgtctgctgc
     1861 cgggcaggct ggcttgcttg actccgagag cctgtcccag agtcctggca ctgagaacag
     1921 ggagctgcgg ggagaaacaa aacttgagca gatggaccaa tcggacagtg agtcggactg
     1981 cagtatggac acaagcgagg tcagcctcga atgcgagcgg atggaacaga cagacgcttc
     2041 ctgtgcaaac agtaggcccg aggagaacgt ctgacagagg ctgtgaccct gccagcagca
     2101 ggcccgtgtc ttacctgtac agtgtttgta ttccacacgg gaacagtttg gagaggcact
     2161 ttgtaatact cctgtgcctg tgttggccta gcccctgtgt ctactccttg tccctagcac
     2221 tgtaactgcc acccagtctg tgtcagcttg cagcagccct taccctgttg ctgtatccca
     2281 caagcatctg gatgagtgcg gaggaatgga ccatgttact tcgagttgtc ctacattcaa
     2341 aacagaaaga ctctctaaac tactgttgtg catggcaagg cctttgtctc atgcttgcct
     2401 agtgttcctc tagctctgac atagtcgctg aagtcctggc actgggagag ctctgcagaa
     2461 tactgagatc gcattgaagg gaaggcagaa agtctgatta acccttggag ggaactccag
     2521 ttttgagtta attcaactag aaagcatgaa aagcatctct gggggtttct gaggttggat
     2581 ttttgcaaag gaggaagcct tgttttgaag cctgtggttt catccagtgc aagttgaatg
     2641 tgaataatct gtgaagacct gaaacagagg tggctttaga aagggccaag acaagagcag
     2701 ctgccggaca ggcaagcaga ggcaggaaga tgcggagttc aagaacagcc ttggctactt
     2761 accaaattct agttcaaact gaattccacc gtaaaaacaa aacaaagcta aaagcaccag
     2821 ccagctctga atattcagct gaagttgggg gtggatattg gaggcgtttg tcatggccaa
     2881 tggcttgcca ttagaagagc cctttctagc ctacaacatc aggattgcca ggaccagaga
     2941 agatctgcca gggtcatgtg accccatcag cattatgttt catcctcctc agccactcct
     3001 cttttccagt ggtaataggg ggctggggga tagggacaca gagactgtga ctgcatccag
     3061 tgactgttga caaacaagag agaaggactt gggggtgaga aatgtgtcac tgtcacccaa
     3121 ggctcctgcg tgaaccacag aaattgaagt tactccggag ggtctcaaga tttcctgctc
     3181 tgcttttggg cctggttcta gagctacaga cggactggtg gttaattccc ctcgaggctg
     3241 gtttcattag ctcttattaa ctagaaccgg ctagccaaac tggaaagttc tttgttaaag
     3301 ccttgcttta cagagcaagg atgggtaaaa agaccttgag ggcgtggtgg aaaaaaccgt
     3361 tcacaaacta gacagagcag cttctgcaag tgtaaatact tagaggattt gtataaaatt
     3421 atacccacac cagcactagt agtaatgatt ctaaattatt gccaaaaagt tttttttgtt
     3481 tgttgttgtt aatttttgca tctatcaaaa gtttacagaa aagaaagcaa aatgcaaagt
     3541 tgtcccttta ctatgcacat gtgtcgtgcg cactgaaaga agccgtgtgg caagagcaac
     3601 caatagaaaa acaaggtata tgacattatt atttttcaag acctattttg accagtttct
     3661 accctgtaaa gcctatttct gtatttatag tttttaacca tggtgaaaat ttttttctat
     3721 tatgagttta tttaaaacca ttttgtctct caagttgctg atgtagcgaa taaacctgct
     3781 ccgggcagac acagtaggaa gctgagacgg accgggcact ggacgataga gaaaagcctg
     3841 aaatgttctc tacagagcca ttgtgaccag cgagttaagg aagggtctct gtcagggtca
     3901 gcctgtggga agagagtgaa tgaatgttct ggtgaaatga atacttttgt ataatggcct
     3961 taaacttttc tggaagcatt tcaaataaat tgcattaaga ata
//
LOCUS       NM_001436735            1859 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 5, mRNA.
ACCESSION   NM_001436735
VERSION     NM_001436735.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.31166.1,
                                           SRR26360181.2145995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000005.1  156719221-156719466
            247-318             JAXUCZ010000005.1  156741558-156741629
            319-408             JAXUCZ010000005.1  156766717-156766806
            409-530             JAXUCZ010000005.1  156784207-156784328
            531-644             JAXUCZ010000005.1  156788909-156789022
            645-786             JAXUCZ010000005.1  156806838-156806979
            787-903             JAXUCZ010000005.1  156807266-156807382
            904-969             JAXUCZ010000005.1  156813995-156814060
            970-1046            JAXUCZ010000005.1  156814589-156814665
            1047-1859           JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1859
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..246
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    244..246
                     /gene="Capzb"
                     /note="upstream in-frame stop codon"
     exon            247..318
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1134
                     /gene="Capzb"
                     /note="isoform 5 is encoded by transcript variant 5;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 5"
                     /protein_id="NP_001423664.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MCINQVEQSEGFTWQDGRSEMNSSDQQLDCALDLMRRLPPQQIE
                     KNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYD
                     PPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAG
                     DGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQ
                     MEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSK
                     QEALKNDLVEALKRKQQC"
     misc_feature    346..1032
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    346..1032
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     exon            319..408
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            409..530
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            531..644
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            645..786
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            787..903
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            904..969
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1046
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1859
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttcttcc cccgcatgtc cagactagtc tcgcttatcc caggctagac cttccttccc
       61 tccaagcacc cttctcgcag gccttcatcc catgggctga acttgggccc ctgcctcggt
      121 cccagggccc aagctaggac cgtggttttc actcctgtgg cccagtctag gcccctttcc
      181 ccaaactctt ctctccatgg ccccagcctg cgcctcgacg atccctttcc agtgaactca
      241 gcctagacca tgtgcatcaa ccaagtggaa cagtctgagg gcttcacgtg gcaagacgga
      301 cggtctgaaa tgaactctag cgatcagcag ctggactgcg ccttggacct gatgaggcgc
      361 ctgcctccac agcagattga gaaaaacctc agcgatctga tcgacctggt ccccagtctg
      421 tgtgaagatc tcctgtcttc tgttgaccag cccctgaaaa ttgccagaga caaggtggtg
      481 ggcaaggact accttttgtg tgactacaac agagacgggg actcctatag gtcaccatgg
      541 agtaacaagt atgaccctcc tttggaagat ggggccatgc catctgctcg gctcagaaag
      601 ctggaggtag aggccaacaa tgccttcgac caataccgag acctgtattt tgaaggtggt
      661 gtctcatcag tctacctctg ggatctcgat catggctttg ctggagtgat cctcataaag
      721 aaggctgggg atggatcaaa gaagatcaaa ggctgctggg attccatcca cgtggtggaa
      781 gtgcaggaga agtccagtgg ccgtactgcc cattacaagt tgacctccac agtgatgcta
      841 tggctgcaaa ccaacaaatc cggctcaggc accatgaacc tgggaggcag cctaaccaga
      901 cagatggaga aggacgaaac tgtgagtgac tgttccccac acatagccaa cattgggcgc
      961 ctggtggagg acatggaaaa caaaatcaga agcacgctga atgagatcta ctttggaaaa
     1021 acaaaggaca tcgtcaacgg gctgaggtct gtgcagacgt ttgcagacaa atcaaagcag
     1081 gaagccctta agaatgacct ggtggaagcc ttgaagagaa agcagcagtg ttaaagacct
     1141 gcttcacgct aaccggacac gccatgcact cgttaggttc ctttctttag aaaactcgtt
     1201 ttctgctcct tttccctctt cctttccctc cctgacggtc acataacagt ttgcatcgac
     1261 cacgcagcgc catctctccc ccaaaataaa gtccaataac caccctctgg ctccaaggcc
     1321 tgcttcccac gacgtttcca tagagaccgt gtggctttgt tcgcctgtcc ccttccttcc
     1381 cttgcccgtt tgtaggcaca ggcgcactgt ctgacatcct ccctccgtct ttttgttaca
     1441 ttggtgtaaa aaatgtaaaa caaaaaaatt ttatgaacta actggtgtgt gaaagaaggg
     1501 aaactggagc tctgatccgt gtgtgtttgg gggttgcttg gagccggggg ccgggggaca
     1561 ggggacagct atggaggaag gagacatgtc ctcagcactg tcctgcgcag agcaggtgtg
     1621 cccttgtccc aaggagaccg cggtgggggt gggggcgggg ctggcgaccg ctgctctctg
     1681 gccaggtgct tttctgtcaa atttttatgg aatgcaaaag gagttttttg ttttattttg
     1741 ttttttgtaa agcttaaaca gacaaaaaaa atctacatct tctacttgag cctccatact
     1801 taaaaaaaaa aaaggaaaaa aagaacaaaa aaaataaata aaaagaaact gggacacaa
//
LOCUS       NM_001107902            2351 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus SRY-box transcription factor 17 (Sox17),
            transcript variant 2, mRNA.
ACCESSION   NM_001107902 XM_001068621 XM_232640
VERSION     NM_001107902.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Walters,R., Vasilaki,E., Aman,J., Chen,C.N., Wu,Y., Liang,O.D.,
            Ashek,A., Dubois,O., Zhao,L., Sabrin,F., Cebola,I., Ferrer,J.,
            Morrell,N.W., Klinger,J.R., Wilkins,M.R., Zhao,L. and Rhodes,C.J.
  TITLE     SOX17 Enhancer Variants Disrupt Transcription Factor Binding And
            Enhancer Inactivity Drives Pulmonary Hypertension
  JOURNAL   Circulation 147 (21), 1606-1621 (2023)
   PUBMED   37066790
REFERENCE   2  (bases 1 to 2351)
  AUTHORS   Zou,X., Liu,T., Huang,Z., Zhou,W., Yuan,M., Zhao,H., Pan,Z.,
            Chen,P., Shao,Y., Hu,X., Zhang,S., Zheng,S., Zhang,Y. and Huang,P.
  TITLE     SOX17 is a Critical Factor in Maintaining Endothelial Function in
            Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner
  JOURNAL   Adv Sci (Weinh) 10 (14), e2206139 (2023)
   PUBMED   36919784
REFERENCE   3  (bases 1 to 2351)
  AUTHORS   Sangam,S., Sun,X., Schwantes-An,T.H., Yegambaram,M., Lu,Q., Shi,Y.,
            Cook,T., Fisher,A., Frump,A.L., Coleman,A., Sun,Y., Liang,S.,
            Crawford,H., Lutz,K.A., Maun,A.D., Pauciulo,M.W., Karnes,J.H.,
            Chaudhary,K.R., Stewart,D.J., Langlais,P.R., Jain,M., Alotaibi,M.,
            Lahm,T., Jin,Y., Gu,H., Tang,H., Nichols,W.C., Black,S.M. and
            Desai,A.A.
  TITLE     SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads
            of Sex, Metabolism, and Genetics
  JOURNAL   Am J Respir Crit Care Med 207 (8), 1055-1069 (2023)
   PUBMED   36913491
  REMARK    GeneRIF: SOX17 Deficiency Mediates Pulmonary Hypertension: At the
            Crossroads of Sex, Metabolism, and Genetics.
REFERENCE   4  (bases 1 to 2351)
  AUTHORS   Wan,Q., Liu,H., Xu,Y., Zhang,Q. and Tao,L.
  TITLE     Upregulated miR-194-5p suppresses retinal microvascular endothelial
            cell dysfunction and mitigates the symptoms of hypertensive
            retinopathy in mice by targeting SOX17 and VEGF signaling
  JOURNAL   Cell Cycle 22 (3), 331-346 (2023)
   PUBMED   36200131
REFERENCE   5  (bases 1 to 2351)
  AUTHORS   Park,C.S., Kim,S.H., Yang,H.Y., Kim,J.H., Schermuly,R.T., Cho,Y.S.,
            Kang,H., Park,J.H., Lee,E., Park,H., Yang,J.M., Noh,T.W., Lee,S.P.,
            Bae,S.S., Han,J., Ju,Y.S., Park,J.B. and Kim,I.
  TITLE     Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via
            HGF/c-Met Signaling
  JOURNAL   Circ Res 131 (10), 792-806 (2022)
   PUBMED   36205124
REFERENCE   6  (bases 1 to 2351)
  AUTHORS   Park,K.S., Wells,J.M., Zorn,A.M., Wert,S.E. and Whitsett,J.A.
  TITLE     Sox17 influences the differentiation of respiratory epithelial
            cells
  JOURNAL   Dev Biol 294 (1), 192-202 (2006)
   PUBMED   16574095
REFERENCE   7  (bases 1 to 2351)
  AUTHORS   Niimi,T., Hayashi,Y., Futaki,S. and Sekiguchi,K.
  TITLE     SOX7 and SOX17 regulate the parietal endoderm-specific enhancer
            activity of mouse laminin alpha1 gene
  JOURNAL   J Biol Chem 279 (36), 38055-38061 (2004)
   PUBMED   15220343
REFERENCE   8  (bases 1 to 2351)
  AUTHORS   Murakami,A., Shen,H., Ishida,S. and Dickson,C.
  TITLE     SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
  JOURNAL   J Biol Chem 279 (27), 28564-28573 (2004)
   PUBMED   15082719
REFERENCE   9  (bases 1 to 2351)
  AUTHORS   Kanai-Azuma,M., Kanai,Y., Gad,J.M., Tajima,Y., Taya,C.,
            Kurohmaru,M., Sanai,Y., Yonekawa,H., Yazaki,K., Tam,P.P. and
            Hayashi,Y.
  TITLE     Depletion of definitive gut endoderm in Sox17-null mutant mice
  JOURNAL   Development 129 (10), 2367-2379 (2002)
   PUBMED   11973269
REFERENCE   10 (bases 1 to 2351)
  AUTHORS   Kanai,Y., Kanai-Azuma,M., Noce,T., Saido,T.C., Shiroishi,T.,
            Hayashi,Y. and Yazaki,K.
  TITLE     Identification of two Sox17 messenger RNA isoforms, with and
            without the high mobility group box region, and their differential
            expression in mouse spermatogenesis
  JOURNAL   J Cell Biol 133 (3), 667-681 (1996)
   PUBMED   8636240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001107902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR22582419.366550.1, FM036904.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  19814333-19814484
            153-247             JAXUCZ010000005.1  19816938-19817032
            248-633             JAXUCZ010000005.1  19817317-19817702
            634-2351            JAXUCZ010000005.1  19818140-19819857
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2351
                     /gene="Sox17"
                     /note="SRY-box transcription factor 17"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
     exon            1..152
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            153..247
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            248..633
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    297..299
                     /gene="Sox17"
                     /note="upstream in-frame stop codon"
     CDS             327..1598
                     /gene="Sox17"
                     /note="SRY-box containing gene 17; SRY (sex determining
                     region Y)-box 17; SRY box 17"
                     /codon_start=1
                     /product="transcription factor SOX-17"
                     /protein_id="NP_001101372.1"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
                     /translation="MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKV
                     KGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALA
                     EPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGAHYRDCQGLGAPALDGYP
                     LPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQVSDYAVPAEPSAGPMRVGPDP
                     SGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQPPPPPPPPPPPQQH
                     PTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEMGLPYQGHD
                     CGVNLSDSHGAISSVVSDASSAVYYCNYPDI"
     misc_feature    510..752
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    510..752
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    order(531..536,540..545,549..554,564..566,573..575,
                     606..614,621..626,633..635,642..644,732..737,741..749)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    order(531..536,540..545,549..554,564..566,573..575,
                     606..614,621..626,633..635,642..644,732..737,741..749)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    933..1085
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     misc_feature    933..1085
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     exon            634..2351
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gataacgtcg cgaactcggc ttccaacacc catttagtga agaaactgaa acatggtcca
       61 ctcacaactg ctggcgggtc tgaagtgcgg ttgcccccaa cacttctccc aaagtatcta
      121 tcaagagaat ggtcagcaga aattagatct agtgagcaat atctccagac atttgaattt
      181 cagccgtcct atttccccga gaggacttgg cgccagagcc cggctccagc cagttttccc
      241 ctggcagctt cccatccccg cctcagggtc cggggaagcg gcgtgtcccg tggccgtagc
      301 agagcgcggg gtcggtctgg agcgccatga gcagcccgga tgcgggatac gccagtgacg
      361 accagagcca gcctcggagc gcgcagcccg cggtgatggc cgggttgggc ccctgtccct
      421 gggccgagtc cctgagctct ctcggggacg taaaggtgaa aggagaggtg gtggcgagta
      481 gcggggcgcc agccgggacc tcgagtcgag ccaaagccga gtctcgcatc cggcggccga
      541 tgaatgcctt tatggtgtgg gccaaagacg aacgcaagcg gctggcacag cagaacccgg
      601 atctgcacaa cgcagagctg agcaagatgc taggcaaatc ctggaaggcg ttgaccttgg
      661 cggagaagcg gcccttcgtg gaagaggccg agcggctgcg tgtgcagcac atgcaggacc
      721 atcccaacta caagtaccgg ccgcggcggc gcaagcaggt gaagcgcatg aaacgggtgg
      781 agggaggctt cctgcacgct ctcgccgagc ctcaggccgg cgcgcttggt cccgagggcg
      841 gccgcgtggc catggatggc ctgggtctgc ctttcccgga gccaggctat ccggccggcc
      901 cgccgctgat gtccccgcac atgggcgccc actaccgtga ctgccaggga ctgggcgcac
      961 ccgcgctcga cggctaccct ctgcccactc cggacacatc cccgttggat ggcgtggagc
     1021 aggacccggc tttctttgct gccccgctgc caggggactg cccggcggcc ggagcctaca
     1081 cgtatgctca ggtctcggac tatgcggtgc ccgcagagcc gtccgctggc cccatgcgag
     1141 tgggacccga cccctccggc tctgcgatgc cggggatcct ggcgcccccc agtgctctgc
     1201 acctgtacta cggcgcgatg ggctcgcccg cggcaagcgc cgggcgcggt ttccacgctc
     1261 agccccagca gccactgcaa ccgcagccac cgccgccacc accaccgcct ccaccgccgc
     1321 agcagcaccc gacgcacggt ccggggcagc cttctccacc tcccgaggct ctgccctgcc
     1381 gggatggcac ggaacccaac cagcccactg agctactagg ggaggtggac cgcacggaat
     1441 tcgaacagta tttgcacttt gtgtataagc cggagatggg tcttccctac cagggacacg
     1501 actgcggtgt gaacctctcg gacagccacg gagccatttc ctccgtggtg tccgacgcta
     1561 gctcagcggt ctactactgc aactaccctg acatctgacg gttgccgatt tgacctgcgg
     1621 gccagaagca gtgttacaca cttcctggaa gcgctaagga aatccttagc gtcacgctgt
     1681 tttgttttta agttgccttg gcatataatt tatggtaatt tattttgtct gccacttgaa
     1741 cagttgaagg gctacatgag attctcattt caaatgcctc gaggggtttg ctccccacca
     1801 tcactgtcca gttttagcca gtttttaata tctcaccaac ttgatccaaa gaaattttgt
     1861 cacgatctta aaaaaatcct ggaatctttt ttaaaaaaat ctctatcaca ttggttttat
     1921 caaagtaatt taaagatcaa cagtaaatat tacacaatta gaagtgtata gttaattgta
     1981 aactttctat tttcttacaa aatttaagaa accctaaata caaacagtgg ggtgttcaga
     2041 tgtgatatcg ttgttctcct acgaaaaaaa ttctcacaga atgaacttgc tatgtacatt
     2101 ccaaaatatt ggtttctaaa aataatactg taaatgtttt taattctgta tactttaata
     2161 aggctgttca aaaattctgg tttttttttt tgtcatcttg atatctgcca aaagagcttt
     2221 tcagatatat ctgttttcgt ttgtgttttc ttccaaatgt ctttatccct ttccccacaa
     2281 aatttgcctt taatccccac atttttagag tcagagaaac taatcaaaat aaaatttgtt
     2341 gtgactgtta a
//
LOCUS       NM_001436737            2416 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus pleckstrin homology domain containing N1
            (Plekhn1), transcript variant 3, mRNA.
ACCESSION   NM_001436737 XM_006239564
VERSION     NM_001436737.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Kuriyama,S., Tsuji,T., Sakuma,T., Yamamoto,T. and Tanaka,M.
  TITLE     PLEKHN1 promotes apoptosis by enhancing Bax-Bak
            hetro-oligomerization through interaction with Bid in human colon
            cancer
  JOURNAL   Cell Death Discov 4, 11 (2018)
   PUBMED   29531808
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Maeda,A., Uchida,M., Nishikawa,S., Nishino,T. and Konishi,H.
  TITLE     Role of N-myristoylation in stability and subcellular localization
            of the CLPABP protein
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1249-1256 (2018)
   PUBMED   29180010
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Nishino,T., Matsunaga,R., Jikihara,H., Uchida,M., Maeda,A., Qi,G.,
            Abe,T., Kiyonari,H., Tashiro,S., Inagaki-Ohara,K., Shimamoto,F. and
            Konishi,H.
  TITLE     Antagonizing effect of CLPABP on the function of HuR as a regulator
            of ARE-containing leptin mRNA stability and the effect of its
            depletion on obesity in old male mouse
  JOURNAL   Biochim Biophys Acta 1861 (11), 1816-1827 (2016)
   PUBMED   27616329
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Sano,E., Shono,S., Tashiro,K., Konishi,H., Yamauchi,E. and
            Taniguchi,H.
  TITLE     Novel tyrosine phosphorylated and cardiolipin-binding protein
            CLPABP functions as mitochondrial RNA granule
  JOURNAL   Biochim Biophys Acta 1783 (6), 1036-1047 (2008)
   PUBMED   18191643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006239564.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.25942.1,
                                           SRR26643294.24145.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000005.1  172094731-172094855 c
            126-225             JAXUCZ010000005.1  172094539-172094638 c
            226-372             JAXUCZ010000005.1  172091810-172091956 c
            373-453             JAXUCZ010000005.1  172091631-172091711 c
            454-526             JAXUCZ010000005.1  172091478-172091550 c
            527-651             JAXUCZ010000005.1  172091200-172091324 c
            652-765             JAXUCZ010000005.1  172091015-172091128 c
            766-846             JAXUCZ010000005.1  172090828-172090908 c
            847-922             JAXUCZ010000005.1  172090143-172090218 c
            923-1071            JAXUCZ010000005.1  172089852-172090000 c
            1072-1212           JAXUCZ010000005.1  172089578-172089718 c
            1213-1359           JAXUCZ010000005.1  172089217-172089363 c
            1360-1500           JAXUCZ010000005.1  172088916-172089056 c
            1501-1731           JAXUCZ010000005.1  172088527-172088757 c
            1732-1780           JAXUCZ010000005.1  172088244-172088292 c
            1781-2416           JAXUCZ010000005.1  172087524-172088159 c
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2416
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="pleckstrin homology domain containing N1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
     exon            1..125
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="upstream in-frame stop codon"
     CDS             43..1884
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pleckstrin homology domain containing, family N member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family N
                     member 1 isoform 3"
                     /protein_id="NP_001423666.1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
                     /translation="MGNSHCVPQTPRRLRASFSRKPSLKGNREDSARKLAGLFGTEAR
                     PDGDTAANKIFHYIPGTDILGPENHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKV
                     QLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELSICPIDGSREHAFQI
                     TGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLRQCHSAPPQGSLGDKLPWTQLWRA
                     HGCEPMNSAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLNFKGELPLSAI
                     HINLEEKEKEIRSFLIEGRLINTIRVVCASYEDYSQWLLCLRTVSHRDGAHLLPGPES
                     FPGLQRPTQVLGRGRGSLSSNGRTSRKLECPVFPTSQSLPEPSVPTTIGVPAHPVPNQ
                     TNSNCVSTGQTKVELRHSGSSQFPRGKAQREVSGSTAPLPLHLDLTKMSVLNLDSGPE
                     AQDCSPDIPHSPLYADPYTPPAIAHHKITDIQGLDEQFLCAVQTSPGPELSSPFPSVS
                     VSVPVSDSNSGISSSPRPLGSHLLSKKGALQSRASQRHRGSIKSRAPQPSDFPQLVTP
                     AREGTPSSLPPPPDEEAPIWNKTSSPSHQKWSHPRKPAVEGGFIQWI"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     exon            126..225
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            226..372
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            373..453
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            454..526
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            527..651
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            652..765
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            766..846
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            847..922
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1071
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1212
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1359
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1500
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1731
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1780
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2416
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgtcg acctgccctg cccaagctag cagctgccat ccatggggaa cagccactgc
       61 gtccctcaga cccccaggag gctacgggcc tccttttcca gaaaaccctc gctcaaggga
      121 aacagagaag acagcgccag gaagctggct ggcctgtttg gcaccgaggc taggcctgat
      181 ggggacaccg cagctaacaa gatcttccac tacatccctg ggacggacat cctgggccca
      241 gaaaatcatc cagaaaacct ggaacagcca ttcctgagtg tattcaaaaa agggtggcgg
      301 aggacacctg tgaggaacct aggcaaggtg gtgcactatt ccaaggttca gctgcggttc
      361 cagcacagcc aggacatcag tgactgctat ctggaactgt tcccctccca cctgtacttc
      421 caggcccatg gttctgaagg acttacattc caggggctgc taccactgac ggaattgagc
      481 atctgcccga ttgatgggtc cagagagcat gccttccaga ttacaggccc actgcctgcc
      541 ccactccttg ttctctgcca cagtgaggcc gagctcagcc attggctcta ccacctggaa
      601 aagcaaatgg ctctcctggg tctgcggcaa tgccactcag cacccccaca gggttctcta
      661 ggagataaac tcccctggac ccagctatgg cgagcgcacg ggtgtgaacc catgaacagc
      721 gcaatctgtg cctcaagggt caagctgcag catctgccct cccaggagca gtgggaccgg
      781 cttctggtac tgtacccagc atccctggcc atcttctctg aggagccaga aggccttaac
      841 tttaaggggg agcttccact aagtgccatc catatcaact tagaagagaa ggaaaaagag
      901 atccgctcct ttctcatcga aggccgtctc atcaacacca tccgagtggt gtgtgccagt
      961 tatgaggatt acagtcaatg gctgctgtgc ctcaggacgg tctctcacag ggatggggcc
     1021 cacctgctgc ctggcccaga gagtttccca ggactacaga gacccacaca ggttttaggt
     1081 agaggccgag gttcactctc ttccaatgga cgaaccagcc ggaaattaga gtgtccagtg
     1141 ttccctacca gccaatccct ccctgagccc tcagtgccaa ccaccatagg tgtccctgcc
     1201 catcctgtgc ctaaccagac caactctaac tgtgtcagca ctggccaaac gaaggtagag
     1261 ctgaggcaca gtggcagtag ccagttcccc aggggcaaag ctcaaagaga agtatctggc
     1321 tcaactgccc cactgcccct gcacctggac ctgacgaaga tgagtgtcct gaacctagat
     1381 agtggcccag aggctcagga ttgctctcca gacattccac actccccgct ctatgctgat
     1441 ccctacacac caccagctat agctcaccac aagattacag acatccaagg cctggatgag
     1501 cagttcctct gtgcagtaca gacatcacct ggacctgaac tatcaagccc gttcccctca
     1561 gtctctgtgt ctgtgcctgt ctctgactcc aactctggaa tctccagctc cccccggcct
     1621 ctgggctcac acttgctctc caagaaagga gccctgcagt ccagagcttc ccagagacac
     1681 cggggttcca tcaagagcag ggccccacag ccctcagact tccctcagct tgtcacacct
     1741 gccagagaag gtacacccag ttccctgcca cctcccccag atgaagaggc tcctatctgg
     1801 aacaagactt cctctccctc ccaccagaag tggtcacatc ccaggaagcc tgcggtggaa
     1861 gggggattca tccagtggat ctgatggccc ccgagtgagc tgctgcttct caaaaaacac
     1921 aaacagccag caccaaccgg gataagagta tgcagttcgg ccagtccttt gacttatatt
     1981 aaatacacca gggcctaacc ccatcaggtc gagggtgttt ctagaatttt gaggatagag
     2041 gcacctctca ccaggctcta gctactcagc tttagcagtt ggaacaaatg aaaggaggta
     2101 accctaggaa cgaaccagtg agggacatca gtaagattct gtacaacccc agaagctata
     2161 cctctagggg gagaggtggg ggtgctagtg caggtcttta cttagaagtg gggaacagca
     2221 tgcgtgtgaa atacagagca ctgaaaaagt caggttgtca aacccagcct gtgaagccag
     2281 aaggcatgag ggtcagagat cattagggtg agagctatta caagaagcaa aggagtatag
     2341 gaaaagctag tactgttggg tgcacagggt aaggttggtc agaaaaatga acaccataaa
     2401 caagaaagag atttta
//
LOCUS       NM_001436726            2366 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22),
            transcript variant 5, mRNA.
ACCESSION   NM_001436726
VERSION     NM_001436726.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1942386.1,
                                           SRR21887622.1942385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345331, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000016.1  8588000-8588188
            190-366             JAXUCZ010000016.1  8611088-8611264
            367-574             JAXUCZ010000016.1  8626516-8626723
            575-707             JAXUCZ010000016.1  8630072-8630204
            708-781             JAXUCZ010000016.1  8630924-8630997
            782-903             JAXUCZ010000016.1  8631987-8632108
            904-1789            JAXUCZ010000016.1  8634177-8635062
            1790-2366           JAXUCZ010000016.1  8637247-8637823
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2366
                     /gene="Arhgap22"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
     exon            1..189
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2018
                     /gene="Arhgap22"
                     /note="isoform 4 is encoded by transcript variant 5; rho
                     GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22 isoform 4"
                     /protein_id="NP_001423655.1"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
                     /translation="MGLCCCKDWRGHLRAPKGGAAEREKVPANPEALLLMASSQRDME
                     DWVQAIRRVIWAPLGGGTSRSSHAHPVEPLSTGIFGQRLEDTVHHERKFGPRLAPLLV
                     EQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLY
                     LRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICRFLD
                     EVQAHSDVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHGQLFA
                     TPSFEEPASPRGTVQGTVEWGSEEVTRDHQGEPGSSGLPTHRTSSLDGPAAAVLSRTS
                     PPRLGSQAGPAATSPGKRMHTLPGWKSSFRQQGSRSESPKGVSSSLEVPIISSGGNWL
                     INGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSHLSSTASVASTAWSVASSSR
                     EASIGSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHPSPDLGHSLDEACVGSGSS
                     EPNDPGSPSQAHVRRCRALQGQVAELRAELCHQRIEYQRSLKSIEEGNSDLRKQMCRL
                     EEELDQEKKKYAMLEIKLRNSERAREDAERRNQLLQREMEEFFATLGSLTAGTKGARA
                     PE"
     misc_feature    <189..320
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    <189..320
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    366..962
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    366..962
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    order(498..500,609..611,621..623,834..836,843..848,
                     918..920)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    order(498..500,609..611,621..623,834..836,843..848,
                     918..920)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    498..500
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    498..500
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    <1011..>1958
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1011..>1958
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1689..>1961
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1689..>1961
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            190..366
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            367..574
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            575..707
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            708..781
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            782..903
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1789
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2366
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgcgagg accagggaga gaacggagtc ccggttcgcc ccacgagccc agggggctag
       61 tgcgggccag ccaggccgct ccgggggtgt cgacgggggc ggggagcgga ggcgagcggc
      121 cggggagagg cggtgccatg gggctgtgct gctgcaagga ctggagagga cacctgcgag
      181 cgcccaaagg cggtgccgca gagcgggaga aggtgccagc caatcctgag gcgctcctgc
      241 tcatggccag ctcccagcgt gatatggagg actgggtgca ggccatccgc cgagtcatct
      301 gggccccgct gggcggaggt acttcccgta gctcgcatgc ccaccctgta gaacccttgt
      361 ctacagggat ctttgggcag cgactggagg acacagtgca ccatgagcgg aagtttggtc
      421 cccggctggc acctctgctg gtggagcagt gtgtggactt catccgggag cgaggactca
      481 gtgaagaggg gctcttccgt atgcccggcc aggccaacct ggtgagggac ctgcaggatt
      541 ccttcgactg tggggagaag ccgctgtttg acagcaccac agacgtgcac acagtggcct
      601 ccttgctgaa gctctacctt cgggagctcc cggagccggt catccctttc gccaggtatg
      661 aggacttcct cagctgcgcc cagctgctca ccaaggacga gggggagggg accgtggagt
      721 tggcgaaaca agtgagcaac cttcctcagg ccaactacaa cctgctcaga tacatctgca
      781 ggtttctgga tgaagtgcag gcccactcag acgtcaacaa gatgagcgtc cagaacttgg
      841 caactgtctt tggccctaac atcctccggc cacaggtgga ggatccagtc accatcatgg
      901 aaggcacatc tttggttcag catctgatga ctgtcctcat ccgaaaacac ggacagctct
      961 ttgccacgcc ctcctttgaa gaacctgctt caccacgtgg tactgtccag ggcacagtag
     1021 agtggggctc tgaagaggtc accagagacc accagggcga gcctgggagc tctggcttgc
     1081 ccacacacag gacttcctct ctggatgggc cagctgcagc agtgctctct agaacttctc
     1141 cgccacgcct tggcagccaa gccggccctg cggccaccag ccctgggaag aggatgcata
     1201 ctttgcctgg ctggaagtct tcttttcggc agcaggggtc ccggtcagag agcccaaagg
     1261 gggtcagctc atccttagag gtacccatca tctcctctgg tgggaactgg ctcataaacg
     1321 ggctatcgtc tcttcgcagc caccgtcggg cctcatcagg ggaccggctt aaggatacag
     1381 gctcagcaca gagactctcc acctatgata acgtgccacc atccagccac ctttctagca
     1441 ctgccagcgt ggccagcacg gcatggtctg tagcctcatc ctcccgagag gcctccatcg
     1501 gcagctgcac tgcctgccgg gccagcaact cttctgcctg cagctcctta cacactgagt
     1561 gggcactcga gccctctcct ctccccagca gcagtgaggg ccacccgtcc ccggacctgg
     1621 gccacagctt ggatgaggca tgtgtgggca gtggcagcag tgagcccaat gacccgggca
     1681 gtccctcaca ggcccatgtt cgccgctgcc gggctctcca gggccaggtg gccgagctca
     1741 gggcggagct gtgtcaccag aggattgagt accagaggag cctgaaaagc atcgaggagg
     1801 gcaattctga cctgcggaag cagatgtgtc ggttggaaga ggagctggac caggagaaga
     1861 agaagtatgc catgctggag atcaagcttc ggaactccga gcgagcacgt gaggacgcag
     1921 agcgcaggaa ccagttgctg cagagggaga tggaggagtt cttcgccacc ctgggaagct
     1981 tgactgctgg gaccaaaggg gccagagccc cagagtgaaa ggagcggaag cgcatgtcca
     2041 cctatgtcca ctcactttcc ctgcagggct ggccacaggc tgcagaggaa gccgggagct
     2101 tcaagtttgg gccaggccac cagcagggtc atctgcctcc aagtgccaga tagagagggg
     2161 cctgacgcca gaatgggtac tgtcaggatc ccacatagtc caggcaggat ctggatactt
     2221 ctccacacat acgggtccca ggaggtgtca ggggcgatgg tgccaagatc atgagcatca
     2281 gcctctcctc caggaagagt cagtccccag tggccacctg gagagccagg ccaccgccaa
     2341 gaactattaa atgtgctctg aaagca
//
LOCUS       NM_001436761            2647 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 6, mRNA.
ACCESSION   NM_001436761 XM_006237832
VERSION     NM_001436761.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2647)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006237832.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1447106.1,
                                           SRR26360176.1380079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000005.1  21322310-21322426   c
            118-204             JAXUCZ010000005.1  21318760-21318846   c
            205-593             JAXUCZ010000005.1  21316424-21316812   c
            594-758             JAXUCZ010000005.1  21304734-21304898   c
            759-952             JAXUCZ010000005.1  21301659-21301852   c
            953-1013            JAXUCZ010000005.1  21296573-21296633   c
            1014-1153           JAXUCZ010000005.1  21294405-21294544   c
            1154-2647           JAXUCZ010000005.1  21291897-21293390   c
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2647
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..117
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            118..204
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            205..593
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1171
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform b is encoded by transcript variant 6;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform b"
                     /protein_id="NP_001423690.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKPLTRP"
     misc_feature    575..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    575..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(653..655,662..664,671..673,716..727,860..868)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(653..655,662..664,671..673,716..727,860..868)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            594..758
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            759..952
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1013
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2647
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcaggtg tttaaagaaa gccggcgcta tctgagagtc cgcctctccg gggtcaaccg
       61 cggactagct gccgacgtcg ccgaggataa cctgatcttc tgtgacttcc ttgtcaggtt
      121 cacccccgct gcagcagggc tctgctctct gactgagtgg tgctgtgtta catggatctg
      181 tcatttctat tcagtcatca gttggcattg cagtaacacc tatggcaatg aagaaagaga
      241 cagaatttgg gattttcatc taaggaaaat gataaataac aaccagacgt gtgctgcagg
      301 gcaggactcc gtgccctacg tgacctgtat gcttcacgtg ctggaagagt ggttgggtgt
      361 ggaacagttg gaggactacc tgaattttgc gaaccatctc ttgtgggtct tcaccccgct
      421 gatcctttta atacttccgt actttaccat cttccttctc taccttacta ttattttcct
      481 ccacatctat aagaggaaga atgtgttaaa agaagcctac tctcacaact tgtgggatgg
      541 cgcgaggaaa acagtggcaa ccctgtggga tggacatgcg gcggtttggc atggttatga
      601 agttcacggg atggaaaaga taccagaagg accagcactt ataatttttt atcatggagc
      661 tattcccata gacttttact acttcatggc taaaattttc atccacaaag gcagaacttg
      721 ccgagtggta gctgaccact ttgtctttaa aatcccaggg ttcagtttat tacttgatgt
      781 attttgtgct cttcatggac caagagaaaa atgtgttgaa atcttgagga gtggtcactt
      841 gttagctatt tcaccgggtg gagttcgaga agccttactt agtgatgaaa cctacaacat
      901 catatggggt aatcgtaaag gctttgctca ggttgcaatc gatgcaaaag tgcccattat
      961 tcctatgttt acacaaaaca tccgagaagg atttagatca ctcggaggaa caagattgtt
     1021 taaatggctt tatgaaaaat tccgctatcc gtttgctcca atgtatggag gttttcctgt
     1081 gaagttgcgg accttcttgg gtgatcctat tccgtatgac ccagaggtaa cagcagaaga
     1141 attagctgaa aagcccctga caaggccctg aaatctgaaa tgctcaaatt gctagaagaa
     1201 aacgcaggca gtgccctgtg agacctgggt gtgggacaga aatgcttctg caagtcccat
     1261 ctcatgaaaa tcccacaaga tgaactgagc tgaggctgaa ccaatagtgg ctttactttt
     1321 gttttctaaa tagactaaga acgctgttca agctttgatc gacaagcacc aaaggatacc
     1381 ggggaacatt aggagtgctt tgctggaccg ctttcataaa gagcagaagg ctaattgaca
     1441 gataatttcg tgtgtctcta atgccaagtt tgcatctgtg gtactgcctt ttaaactttt
     1501 gtaggttgta taatagtctt tttaaaacct gctaatgagc atctttcttt agaatttaaa
     1561 ctttctatgg ttaatcttac cctttcaatc agttttgtca aatgtagtaa gtaactcacc
     1621 atttgcttga ctcagaagat gatcatgttg catttgcaat ccttagtagt atatgatagg
     1681 cacaagtctt cctggatacc agcagtctag gttaggcaga cttcactaaa ttatgcttct
     1741 gtgtttgtgt ctgttgtgcc aatgggatgg tgagaggtac ctgagctggg gtgtagcact
     1801 tgcttagttt aggtgagcgg tgcctttgta tccatccttc attccactca caactgctgg
     1861 taagttgtga aacgcttttg cacctccgtg gtttatgtta agcatggtaa tactgtggtg
     1921 gtgaacatta agttgcttat gtctactgtg atatatccgt atctatatat ctgatagata
     1981 tctgtagtga gaaatctgta attgaattga ttcctgaatc ctttaggagt tatgtacatt
     2041 tttgtttatt gggtattgaa attactcctt cagggatgat gtccagttgc caagcacaat
     2101 gaaagagatg tactattttg taaatcaaat cattgttatt tgtagtattt attaacagag
     2161 ttgtttggta tttattttaa acaaggatct aagtaaatgt ataggatgga ttgtcagcac
     2221 gtgtcttaca cggtgtaaag ataaaatcgt gggcacgctc tgcagtttat gttagagcag
     2281 atcctaggct gaggagtgac aactgaggaa gctctgcctc gcttgtccca gggctcgctt
     2341 ccgtgctctg cagccagtca cgtggttata tctgtaaaat gtacttgaat gatgaatttc
     2401 tgtaaacatg gagtcctctg aaaatgtaat tactttgaat tgttgtcttc ttgaaaactt
     2461 attttaaaag tatttaaaca gccaagtatc atgaattcat cgcagtgtgt cttccccctt
     2521 tgcagtactt gggttttata tggacttttt aactacaagt gtatatttgt gatatgtata
     2581 atgtatgtat aatgtatata gaaatggtgt gaaaataaag ctgaactgca actcctctct
     2641 agtaaaa
//
LOCUS       NM_001436725            2318 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22),
            transcript variant 4, mRNA.
ACCESSION   NM_001436725
VERSION     NM_001436725.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.453722.1,
                                           SRR21887622.1965971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680435, SAMN06680445
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000016.1  8588000-8588188
            190-318             JAXUCZ010000016.1  8611088-8611216
            319-526             JAXUCZ010000016.1  8626516-8626723
            527-659             JAXUCZ010000016.1  8630072-8630204
            660-733             JAXUCZ010000016.1  8630924-8630997
            734-855             JAXUCZ010000016.1  8631987-8632108
            856-1741            JAXUCZ010000016.1  8634177-8635062
            1742-2318           JAXUCZ010000016.1  8637247-8637823
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2318
                     /gene="Arhgap22"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
     exon            1..189
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1970
                     /gene="Arhgap22"
                     /note="isoform 3 is encoded by transcript variant 4; rho
                     GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22 isoform 3"
                     /protein_id="NP_001423654.1"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
                     /translation="MGLCCCKDWRGHLRAPKGGAAEREKVPANPEALLLMASSQRDME
                     DWVQAIRRVIWAPLGGGIFGQRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEG
                     LFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYED
                     FLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICRFLDEVQAHSDVNKMSVQNL
                     ATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHGQLFATPSFEEPASPRGTVQG
                     TVEWGSEEVTRDHQGEPGSSGLPTHRTSSLDGPAAAVLSRTSPPRLGSQAGPAATSPG
                     KRMHTLPGWKSSFRQQGSRSESPKGVSSSLEVPIISSGGNWLINGLSSLRSHRRASSG
                     DRLKDTGSAQRLSTYDNVPPSSHLSSTASVASTAWSVASSSREASIGSCTACRASNSS
                     ACSSLHTEWALEPSPLPSSSEGHPSPDLGHSLDEACVGSGSSEPNDPGSPSQAHVRRC
                     RALQGQVAELRAELCHQRIEYQRSLKSIEEGNSDLRKQMCRLEEELDQEKKKYAMLEI
                     KLRNSERAREDAERRNQLLQREMEEFFATLGSLTAGTKGARAPE"
     misc_feature    <189..320
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    <189..320
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    318..914
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    318..914
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    order(450..452,561..563,573..575,786..788,795..800,
                     870..872)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    order(450..452,561..563,573..575,786..788,795..800,
                     870..872)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    450..452
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    450..452
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    <963..>1910
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <963..>1910
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1641..>1913
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1641..>1913
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            190..318
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            319..526
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            527..659
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            660..733
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            734..855
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1741
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2318
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgcgagg accagggaga gaacggagtc ccggttcgcc ccacgagccc agggggctag
       61 tgcgggccag ccaggccgct ccgggggtgt cgacgggggc ggggagcgga ggcgagcggc
      121 cggggagagg cggtgccatg gggctgtgct gctgcaagga ctggagagga cacctgcgag
      181 cgcccaaagg cggtgccgca gagcgggaga aggtgccagc caatcctgag gcgctcctgc
      241 tcatggccag ctcccagcgt gatatggagg actgggtgca ggccatccgc cgagtcatct
      301 gggccccgct gggcggaggg atctttgggc agcgactgga ggacacagtg caccatgagc
      361 ggaagtttgg tccccggctg gcacctctgc tggtggagca gtgtgtggac ttcatccggg
      421 agcgaggact cagtgaagag gggctcttcc gtatgcccgg ccaggccaac ctggtgaggg
      481 acctgcagga ttccttcgac tgtggggaga agccgctgtt tgacagcacc acagacgtgc
      541 acacagtggc ctccttgctg aagctctacc ttcgggagct cccggagccg gtcatccctt
      601 tcgccaggta tgaggacttc ctcagctgcg cccagctgct caccaaggac gagggggagg
      661 ggaccgtgga gttggcgaaa caagtgagca accttcctca ggccaactac aacctgctca
      721 gatacatctg caggtttctg gatgaagtgc aggcccactc agacgtcaac aagatgagcg
      781 tccagaactt ggcaactgtc tttggcccta acatcctccg gccacaggtg gaggatccag
      841 tcaccatcat ggaaggcaca tctttggttc agcatctgat gactgtcctc atccgaaaac
      901 acggacagct ctttgccacg ccctcctttg aagaacctgc ttcaccacgt ggtactgtcc
      961 agggcacagt agagtggggc tctgaagagg tcaccagaga ccaccagggc gagcctggga
     1021 gctctggctt gcccacacac aggacttcct ctctggatgg gccagctgca gcagtgctct
     1081 ctagaacttc tccgccacgc cttggcagcc aagccggccc tgcggccacc agccctggga
     1141 agaggatgca tactttgcct ggctggaagt cttcttttcg gcagcagggg tcccggtcag
     1201 agagcccaaa gggggtcagc tcatccttag aggtacccat catctcctct ggtgggaact
     1261 ggctcataaa cgggctatcg tctcttcgca gccaccgtcg ggcctcatca ggggaccggc
     1321 ttaaggatac aggctcagca cagagactct ccacctatga taacgtgcca ccatccagcc
     1381 acctttctag cactgccagc gtggccagca cggcatggtc tgtagcctca tcctcccgag
     1441 aggcctccat cggcagctgc actgcctgcc gggccagcaa ctcttctgcc tgcagctcct
     1501 tacacactga gtgggcactc gagccctctc ctctccccag cagcagtgag ggccacccgt
     1561 ccccggacct gggccacagc ttggatgagg catgtgtggg cagtggcagc agtgagccca
     1621 atgacccggg cagtccctca caggcccatg ttcgccgctg ccgggctctc cagggccagg
     1681 tggccgagct cagggcggag ctgtgtcacc agaggattga gtaccagagg agcctgaaaa
     1741 gcatcgagga gggcaattct gacctgcgga agcagatgtg tcggttggaa gaggagctgg
     1801 accaggagaa gaagaagtat gccatgctgg agatcaagct tcggaactcc gagcgagcac
     1861 gtgaggacgc agagcgcagg aaccagttgc tgcagaggga gatggaggag ttcttcgcca
     1921 ccctgggaag cttgactgct gggaccaaag gggccagagc cccagagtga aaggagcgga
     1981 agcgcatgtc cacctatgtc cactcacttt ccctgcaggg ctggccacag gctgcagagg
     2041 aagccgggag cttcaagttt gggccaggcc accagcaggg tcatctgcct ccaagtgcca
     2101 gatagagagg ggcctgacgc cagaatgggt actgtcagga tcccacatag tccaggcagg
     2161 atctggatac ttctccacac atacgggtcc caggaggtgt caggggcgat ggtgccaaga
     2221 tcatgagcat cagcctctcc tccaggaaga gtcagtcccc agtggccacc tggagagcca
     2281 ggccaccgcc aagaactatt aaatgtgctc tgaaagca
//
LOCUS       NM_001436733            1643 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 3, mRNA.
ACCESSION   NM_001436733 XM_006239175
VERSION     NM_001436733.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1643)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1643)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1643)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1643)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1643)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1643)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006239175.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.23410.1,
                                           SRR26360186.314000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  156720091-156720192
            103-192             JAXUCZ010000005.1  156766717-156766806
            193-314             JAXUCZ010000005.1  156784207-156784328
            315-428             JAXUCZ010000005.1  156788909-156789022
            429-570             JAXUCZ010000005.1  156806838-156806979
            571-687             JAXUCZ010000005.1  156807266-156807382
            688-753             JAXUCZ010000005.1  156813995-156814060
            754-830             JAXUCZ010000005.1  156814589-156814665
            831-1643            JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1643
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..102
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..918
                     /gene="Capzb"
                     /note="isoform 3 is encoded by transcript variant 3;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 3"
                     /protein_id="NP_001423662.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MMHPSRRSLPFPLNCQLVRVGTADYGGAADQSDQQLDCALDLMR
                     RLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYR
                     SPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAG
                     VILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMN
                     LGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSV
                     QTFADKSKQEALKNDLVEALKRKQQC"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     exon            103..192
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            193..314
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            315..428
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            429..570
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            571..687
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            688..753
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            754..830
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1643
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctggaca tgatgcatcc tagcaggcgc agccttcctt tccccctgaa ctgtcagctt
       61 gtaagggttg gaactgctga ttatggaggt gccgctgatc agagcgatca gcagctggac
      121 tgcgccttgg acctgatgag gcgcctgcct ccacagcaga ttgagaaaaa cctcagcgat
      181 ctgatcgacc tggtccccag tctgtgtgaa gatctcctgt cttctgttga ccagcccctg
      241 aaaattgcca gagacaaggt ggtgggcaag gactaccttt tgtgtgacta caacagagac
      301 ggggactcct ataggtcacc atggagtaac aagtatgacc ctcctttgga agatggggcc
      361 atgccatctg ctcggctcag aaagctggag gtagaggcca acaatgcctt cgaccaatac
      421 cgagacctgt attttgaagg tggtgtctca tcagtctacc tctgggatct cgatcatggc
      481 tttgctggag tgatcctcat aaagaaggct ggggatggat caaagaagat caaaggctgc
      541 tgggattcca tccacgtggt ggaagtgcag gagaagtcca gtggccgtac tgcccattac
      601 aagttgacct ccacagtgat gctatggctg caaaccaaca aatccggctc aggcaccatg
      661 aacctgggag gcagcctaac cagacagatg gagaaggacg aaactgtgag tgactgttcc
      721 ccacacatag ccaacattgg gcgcctggtg gaggacatgg aaaacaaaat cagaagcacg
      781 ctgaatgaga tctactttgg aaaaacaaag gacatcgtca acgggctgag gtctgtgcag
      841 acgtttgcag acaaatcaaa gcaggaagcc cttaagaatg acctggtgga agccttgaag
      901 agaaagcagc agtgttaaag acctgcttca cgctaaccgg acacgccatg cactcgttag
      961 gttcctttct ttagaaaact cgttttctgc tccttttccc tcttcctttc cctccctgac
     1021 ggtcacataa cagtttgcat cgaccacgca gcgccatctc tcccccaaaa taaagtccaa
     1081 taaccaccct ctggctccaa ggcctgcttc ccacgacgtt tccatagaga ccgtgtggct
     1141 ttgttcgcct gtccccttcc ttcccttgcc cgtttgtagg cacaggcgca ctgtctgaca
     1201 tcctccctcc gtctttttgt tacattggtg taaaaaatgt aaaacaaaaa aattttatga
     1261 actaactggt gtgtgaaaga agggaaactg gagctctgat ccgtgtgtgt ttgggggttg
     1321 cttggagccg ggggccgggg gacaggggac agctatggag gaaggagaca tgtcctcagc
     1381 actgtcctgc gcagagcagg tgtgcccttg tcccaaggag accgcggtgg gggtgggggc
     1441 ggggctggcg accgctgctc tctggccagg tgcttttctg tcaaattttt atggaatgca
     1501 aaaggagttt tttgttttat tttgtttttt gtaaagctta aacagacaaa aaaaatctac
     1561 atcttctact tgagcctcca tacttaaaaa aaaaaaagga aaaaaagaac aaaaaaaata
     1621 aataaaaaga aactgggaca caa
//
LOCUS       NM_001436743            3301 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transketolase (Tkt), transcript variant 3, mRNA.
ACCESSION   NM_001436743
VERSION     NM_001436743.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Zhao,Y., Wu,Y., Hu,H., Cai,J., Ning,M., Ni,X. and Zhong,C.
  TITLE     Downregulation of transketolase activity is related to inhibition
            of hippocampal progenitor cell proliferation induced by thiamine
            deficiency
  JOURNAL   Biomed Res Int 2014, 572915 (2014)
   PUBMED   25028661
  REMARK    GeneRIF: results suggest that modulation of transketolase activity
            might be one of the mechanisms by which thiamine regulates the
            proliferation of hippocampal progenitor cells.
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Mitschke,L., Parthier,C., Schroder-Tittmann,K., Coy,J., Ludtke,S.
            and Tittmann,K.
  TITLE     The crystal structure of human transketolase and new insights into
            its mode of action
  JOURNAL   J Biol Chem 285 (41), 31559-31570 (2010)
   PUBMED   20667822
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Wang,J.J., Martin,P.R. and Singleton,C.K.
  TITLE     Aspartate 155 of human transketolase is essential for thiamine
            diphosphate-magnesium binding, and cofactor binding is required for
            dimer formation
  JOURNAL   Biochim Biophys Acta 1341 (2), 165-172 (1997)
   PUBMED   9357955
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   McCool,B.A., Plonk,S.G., Martin,P.R. and Singleton,C.K.
  TITLE     Cloning of human transketolase cDNAs and comparison of the
            nucleotide sequence of the coding region in Wernicke-Korsakoff and
            non-Wernicke-Korsakoff individuals
  JOURNAL   J Biol Chem 268 (2), 1397-1404 (1993)
   PUBMED   8419340
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Abedinia,M., Layfield,R., Jones,S.M., Nixon,P.F. and Mattick,J.S.
  TITLE     Nucleotide and predicted amino acid sequence of a cDNA clone
            encoding part of human transketolase
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1159-1166 (1992)
   PUBMED   1567394
REFERENCE   9  (bases 1 to 3301)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   10 (bases 1 to 3301)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1950922.1,
                                           SRR26360190.2094273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000016.1  5730875-5731064
            191-308             JAXUCZ010000016.1  5740422-5740539
            309-422             JAXUCZ010000016.1  5741405-5741518
            423-520             JAXUCZ010000016.1  5742133-5742230
            521-712             JAXUCZ010000016.1  5747104-5747295
            713-831             JAXUCZ010000016.1  5748625-5748743
            832-1025            JAXUCZ010000016.1  5749659-5749852
            1026-1190           JAXUCZ010000016.1  5750484-5750648
            1191-1347           JAXUCZ010000016.1  5751274-5751430
            1348-1478           JAXUCZ010000016.1  5751544-5751674
            1479-1562           JAXUCZ010000016.1  5752336-5752419
            1563-1656           JAXUCZ010000016.1  5752527-5752620
            1657-1774           JAXUCZ010000016.1  5753479-5753596
            1775-3301           JAXUCZ010000016.1  5754882-5756408
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3301
                     /gene="Tkt"
                     /note="transketolase"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
     exon            1..190
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Tkt"
                     /note="upstream in-frame stop codon"
     CDS             84..1772
                     /gene="Tkt"
                     /EC_number="2.2.1.1"
                     /note="isoform 3 is encoded by transcript variant 3; TK"
                     /codon_start=1
                     /product="transketolase isoform 3"
                     /protein_id="NP_001423672.1"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
                     /translation="MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSA
                     AEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRK
                     ISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSE
                     GSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDVYQKRCEAFGWHAIIVDG
                     HSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYS
                     QVQSKKKILATPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYGLALAKLGHASDR
                     IIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAF
                     FTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSD
                     GVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGA
                     GVTLHEALAAAEMLKKDRRPCTGPLHHQAPGQKAHSRLCQSNQRQDPHRGGPLL"
     misc_feature    84..86
                     /gene="Tkt"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    99..101
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    105..1691
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    105..1691
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    114..116
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    192..194
                     /gene="Tkt"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); other site"
     misc_feature    393..395
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    513..515
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    693..695
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    777..779
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40142; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    804..806
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    855..857
                     /gene="Tkt"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); other site"
     misc_feature    861..863
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    906..908
                     /gene="Tkt"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    942..944
                     /gene="Tkt"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    966..968
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    1116..1118
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     exon            191..308
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            309..422
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            423..520
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            521..712
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            713..831
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1025
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1190
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1347
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1478
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1562
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1656
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1774
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..3301
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggtcact gccggtcgct tcctgagcct cctctggctc tgtgtctctg tcctcagctt
       61 ccacgtcctc gcccgaccgc gccatggagg gttaccataa gccagatcag cagaagctcc
      121 aggccctgaa ggacacagcc aatcgcctgc gcatcagctc catccaggcc accaccgcgg
      181 caggctcggg acaccccaca tcatgctgca gcgctgccga gatcatggct gtcctgtttt
      241 tccataccat gcgctacaag gccctggatc cccgaaaccc tcacaatgat cgctttgtgc
      301 tctccaaggg ccatgcagct cccatcttat atgcagtctg ggctgaagct ggcttcctgc
      361 ctgaggcaga gctgctgaac ctgaggaaaa tcagctctga cttggatggg catcctgtcc
      421 cgaaacaagc cttcaccgat gtggccactg gctccctggg ccaggggctg ggagctgcgt
      481 gcgggatggc atacacaggc aaatacttcg acaaagccag ctaccgagtc tattgcatgc
      541 tgggagacgg ggaggtgtcc gagggctccg tttgggaggc catggccttc gctggaattt
      601 acaagctgga caacctcgtt gccatttttg acatcaaccg tctgggccag agcgacccag
      661 ccccgctgca gcaccaagtg gacgtctacc agaagcgctg tgaggccttt ggctggcatg
      721 ccatcatcgt ggatgggcac agtgtggagg agctgtgcaa ggcctttggt caggccaagc
      781 accaaccaac agccatcatt gccaagacct tcaagggccg cgggatcaca gggattgaag
      841 acaaggaggc gtggcatggg aagcccctcc ccaaaaacat ggctgagcag attatccagg
      901 agatttacag ccaggttcag agcaaaaaga agatcctcgc cacgccccct caggaggatg
      961 ccccttccgt ggacattgcc aacatccgaa tgcctacccc acccaactac aaagtggggg
     1021 acaagatagc cacacggaaa gcctatggat tggcccttgc caagctgggc cacgccagtg
     1081 accgcatcat cgccctggat ggagacacca aaaattccac cttctcagag ctcttcaaaa
     1141 aggagcaccc agaccgtttc atcgagtgct acattgctga gcagaacatg gtgagcattg
     1201 ctgtgggctg tgccacacgt gacaggacag tgcccttctg cagcactttt gcggccttct
     1261 tcacacgcgc cttcgaccag atccgcatgg ccgccatctc cgagagcaac atcaacctct
     1321 gtggctccca ttgcggcgtg tccattgggg aagacgggcc ctcgcagatg gccctggaag
     1381 acctggccat gtttcggtcg gtccctatgt ccaccgtctt ttacccaagt gatggagttg
     1441 ccacagagaa ggcagtggaa ttagcagcca atacaaaggg catctgcttc attcggacca
     1501 gccgcccaga aaatgccatt atctatagca acaacgagga tttccaggtt ggccaagcca
     1561 aggtggtcct gaagagcaag gacgaccaag tgacggtgat cggggctggc gtaactctgc
     1621 acgaggctct ggctgctgca gagatgttga agaaagatcg gcgtccgtgt actggacccc
     1681 ttcaccatca agcccctgga caaaaagctc attctcgact gtgccagagc aaccaaaggc
     1741 aggatcctca ccgtggagga ccactactat gaaggtggca taggcgaggc agtatctgct
     1801 gcggtagtgg gcgaacctgg agtcacagtc actcgcctgg cggtcagcca agtaccacga
     1861 agtgggaagc cagctgagct gctgaagatg tttggtattg acaaagacgc cattgtgcaa
     1921 gctgtgaagg gccttgtcac caagggctag gaaggacatg ggatgccggg tgggtgaact
     1981 acacattcca gggatgttct ggcaaaggtg ctcaagggtg taccgagtgg aaaggtaaat
     2041 atatgttttg agaaaaaaat taatcctgac tgttttcttt gatatgaaca tatccagtat
     2101 aggaagggag aaaggaagag agctggctgt ctagacttgg gggggtcagg atctaaggtg
     2161 taccctggga tccccttctc cagttcagcc tctgcaaagc cagaactact acccactgta
     2221 gcctgccttt tagccagata ggatccagcc ccttttctca ccactgtacc ctaaaggact
     2281 gtggagttct ccctgcctta taaaactttc ctgatccttc ttagccgcct catgcccccc
     2341 aaggtcccgc aaggcttcct tttataggtg gcccactggt aagcttccta ggaattcctc
     2401 agtgtccgta gggaagatga ggcccatttg tggaactagg cacatgtctg ctccttgaaa
     2461 ccggagctgt tcagctggtg agctgcctgg ccagatcctt ccgtgccagg gaactgaatg
     2521 gtaccaactc cagaaacagc agataaggta ggtctcaggg agaagacggt gattcctcag
     2581 tgggtggtct tagggcaaac cctgggagaa actctccttc actgagaaaa gaaggcaagt
     2641 catcgccctg tggggacagc tgaggaactt cccagtcaag agtttggagt ttggacataa
     2701 ttacaatgta ttttcttatg tagtccataa caacaaaagg gtaaagcaga aaatcaggga
     2761 ttcggggtgc ttgggcacca cctggtggcc atctctggta ctacagtgct aaacacaccc
     2821 cacagcaatc tgtggaaggt gctgttttct gagatctggg aagcaactgc tcgcagaagg
     2881 agatggaggt gcccgtgaca gtgctgaatg aacttcgtat gcattttatt tgatccttac
     2941 tccaagatac cattttagaa gatattcctc ttggcccagt gctgaggatt ggtctgttgc
     3001 tttgtatcgt aacatcaaat actgtacctg aaggtctaaa agcttttgtt gtgcaaacct
     3061 tccttaatct aacactattg tttaaataaa aatgactaca gtcaattact ggagggatta
     3121 gaggtaggcc gcttttgagt ttcctggttg ggggttgcgg agggaggaga ggtgagagaa
     3181 ggaagccacc acaggaggag gtgaccatga acaagtattg ggtactctgc cggggaagta
     3241 gcaagtccag cagacaggaa agtagattag ggattacctc cagtaattgt caataaaaca
     3301 a
//
LOCUS       NM_001436740            3071 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus SRY-box transcription factor 17 (Sox17),
            transcript variant 3, mRNA.
ACCESSION   NM_001436740
VERSION     NM_001436740.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Walters,R., Vasilaki,E., Aman,J., Chen,C.N., Wu,Y., Liang,O.D.,
            Ashek,A., Dubois,O., Zhao,L., Sabrin,F., Cebola,I., Ferrer,J.,
            Morrell,N.W., Klinger,J.R., Wilkins,M.R., Zhao,L. and Rhodes,C.J.
  TITLE     SOX17 Enhancer Variants Disrupt Transcription Factor Binding And
            Enhancer Inactivity Drives Pulmonary Hypertension
  JOURNAL   Circulation 147 (21), 1606-1621 (2023)
   PUBMED   37066790
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Zou,X., Liu,T., Huang,Z., Zhou,W., Yuan,M., Zhao,H., Pan,Z.,
            Chen,P., Shao,Y., Hu,X., Zhang,S., Zheng,S., Zhang,Y. and Huang,P.
  TITLE     SOX17 is a Critical Factor in Maintaining Endothelial Function in
            Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner
  JOURNAL   Adv Sci (Weinh) 10 (14), e2206139 (2023)
   PUBMED   36919784
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Sangam,S., Sun,X., Schwantes-An,T.H., Yegambaram,M., Lu,Q., Shi,Y.,
            Cook,T., Fisher,A., Frump,A.L., Coleman,A., Sun,Y., Liang,S.,
            Crawford,H., Lutz,K.A., Maun,A.D., Pauciulo,M.W., Karnes,J.H.,
            Chaudhary,K.R., Stewart,D.J., Langlais,P.R., Jain,M., Alotaibi,M.,
            Lahm,T., Jin,Y., Gu,H., Tang,H., Nichols,W.C., Black,S.M. and
            Desai,A.A.
  TITLE     SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads
            of Sex, Metabolism, and Genetics
  JOURNAL   Am J Respir Crit Care Med 207 (8), 1055-1069 (2023)
   PUBMED   36913491
  REMARK    GeneRIF: SOX17 Deficiency Mediates Pulmonary Hypertension: At the
            Crossroads of Sex, Metabolism, and Genetics.
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Wan,Q., Liu,H., Xu,Y., Zhang,Q. and Tao,L.
  TITLE     Upregulated miR-194-5p suppresses retinal microvascular endothelial
            cell dysfunction and mitigates the symptoms of hypertensive
            retinopathy in mice by targeting SOX17 and VEGF signaling
  JOURNAL   Cell Cycle 22 (3), 331-346 (2023)
   PUBMED   36200131
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Park,C.S., Kim,S.H., Yang,H.Y., Kim,J.H., Schermuly,R.T., Cho,Y.S.,
            Kang,H., Park,J.H., Lee,E., Park,H., Yang,J.M., Noh,T.W., Lee,S.P.,
            Bae,S.S., Han,J., Ju,Y.S., Park,J.B. and Kim,I.
  TITLE     Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via
            HGF/c-Met Signaling
  JOURNAL   Circ Res 131 (10), 792-806 (2022)
   PUBMED   36205124
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Park,K.S., Wells,J.M., Zorn,A.M., Wert,S.E. and Whitsett,J.A.
  TITLE     Sox17 influences the differentiation of respiratory epithelial
            cells
  JOURNAL   Dev Biol 294 (1), 192-202 (2006)
   PUBMED   16574095
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Niimi,T., Hayashi,Y., Futaki,S. and Sekiguchi,K.
  TITLE     SOX7 and SOX17 regulate the parietal endoderm-specific enhancer
            activity of mouse laminin alpha1 gene
  JOURNAL   J Biol Chem 279 (36), 38055-38061 (2004)
   PUBMED   15220343
REFERENCE   8  (bases 1 to 3071)
  AUTHORS   Murakami,A., Shen,H., Ishida,S. and Dickson,C.
  TITLE     SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
  JOURNAL   J Biol Chem 279 (27), 28564-28573 (2004)
   PUBMED   15082719
REFERENCE   9  (bases 1 to 3071)
  AUTHORS   Kanai-Azuma,M., Kanai,Y., Gad,J.M., Tajima,Y., Taya,C.,
            Kurohmaru,M., Sanai,Y., Yonekawa,H., Yazaki,K., Tam,P.P. and
            Hayashi,Y.
  TITLE     Depletion of definitive gut endoderm in Sox17-null mutant mice
  JOURNAL   Development 129 (10), 2367-2379 (2002)
   PUBMED   11973269
REFERENCE   10 (bases 1 to 3071)
  AUTHORS   Kanai,Y., Kanai-Azuma,M., Noce,T., Saido,T.C., Shiroishi,T.,
            Hayashi,Y. and Yazaki,K.
  TITLE     Identification of two Sox17 messenger RNA isoforms, with and
            without the high mobility group box region, and their differential
            expression in mouse spermatogenesis
  JOURNAL   J Cell Biol 133 (3), 667-681 (1996)
   PUBMED   8636240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166978.1, SRR26643294.20369.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  19814333-19814484
            153-962             JAXUCZ010000005.1  19814831-19815640
            963-1353            JAXUCZ010000005.1  19817312-19817702
            1354-3071           JAXUCZ010000005.1  19818140-19819857
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3071
                     /gene="Sox17"
                     /note="SRY-box transcription factor 17"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
     exon            1..152
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            153..962
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1353
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1017..1019
                     /gene="Sox17"
                     /note="upstream in-frame stop codon"
     CDS             1047..2318
                     /gene="Sox17"
                     /note="SRY-box containing gene 17; SRY (sex determining
                     region Y)-box 17; SRY box 17"
                     /codon_start=1
                     /product="transcription factor SOX-17"
                     /protein_id="NP_001423669.1"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
                     /translation="MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKV
                     KGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALA
                     EPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGAHYRDCQGLGAPALDGYP
                     LPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQVSDYAVPAEPSAGPMRVGPDP
                     SGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQPPPPPPPPPPPQQH
                     PTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEMGLPYQGHD
                     CGVNLSDSHGAISSVVSDASSAVYYCNYPDI"
     misc_feature    1230..1472
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    1230..1472
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    order(1251..1256,1260..1265,1269..1274,1284..1286,
                     1293..1295,1326..1334,1341..1346,1353..1355,1362..1364,
                     1452..1457,1461..1469)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    order(1251..1256,1260..1265,1269..1274,1284..1286,
                     1293..1295,1326..1334,1341..1346,1353..1355,1362..1364,
                     1452..1457,1461..1469)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    1653..1805
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     misc_feature    1653..1805
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     exon            1354..3071
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gataacgtcg cgaactcggc ttccaacacc catttagtga agaaactgaa acatggtcca
       61 ctcacaactg ctggcgggtc tgaagtgcgg ttgcccccaa cacttctccc aaagtatcta
      121 tcaagagaat ggtcagcaga aattagatct agctttcgga gaaatcaacc aagacagtga
      181 agacagagaa aatgcattct ggacccgcta ctgtttccaa ccttcatttc aaataaagcc
      241 catagtttat taaaaaaaaa attcacggaa agagaaaatt cggccctggg atctttaaaa
      301 agatgtcggt tactagatgc aaaagagaaa agtcactgtg gaggtgaggg cctgcgccct
      361 tgcttctgag aggcaggaga gctacatggg gaaattgcct caaaacaaac ggaagagata
      421 cgattttttt cccttaaaga ttacctggct aaggaattga ttggtaatat ggctatctct
      481 gcccctataa ccccttataa cccctttggt taaacatctg aaatgcattt ttttgtttgt
      541 ttgttttact ttcaagccaa tgtttttcag gggaaaaaaa gctttgagaa agagcacatt
      601 atcagttaga tttaagacca attgctttta aatcaccaat ttaaaatatt attttcttcg
      661 atttcttaaa gcagatttaa atttaccccc tttgtatgaa tcttaagacc tggaacttta
      721 aacactctca cggatctctc tgcacaacat ccagctttaa atgggagggt cgccattgct
      781 ttataacata acaaattcga gaaagaatgg cttctgtatg agttctttgg agacaagata
      841 gttccagaaa ctgcaggcca ggagctagca aaacctctgt gcgttttgga acctccagta
      901 agccagactt ggtatctgaa ataacacaag gaaacctcag catgttacct catgggccac
      961 aagcaagctt cccatccccg cctcagggtc cggggaagcg gcgtgtcccg tggccgtagc
     1021 agagcgcggg gtcggtctgg agcgccatga gcagcccgga tgcgggatac gccagtgacg
     1081 accagagcca gcctcggagc gcgcagcccg cggtgatggc cgggttgggc ccctgtccct
     1141 gggccgagtc cctgagctct ctcggggacg taaaggtgaa aggagaggtg gtggcgagta
     1201 gcggggcgcc agccgggacc tcgagtcgag ccaaagccga gtctcgcatc cggcggccga
     1261 tgaatgcctt tatggtgtgg gccaaagacg aacgcaagcg gctggcacag cagaacccgg
     1321 atctgcacaa cgcagagctg agcaagatgc taggcaaatc ctggaaggcg ttgaccttgg
     1381 cggagaagcg gcccttcgtg gaagaggccg agcggctgcg tgtgcagcac atgcaggacc
     1441 atcccaacta caagtaccgg ccgcggcggc gcaagcaggt gaagcgcatg aaacgggtgg
     1501 agggaggctt cctgcacgct ctcgccgagc ctcaggccgg cgcgcttggt cccgagggcg
     1561 gccgcgtggc catggatggc ctgggtctgc ctttcccgga gccaggctat ccggccggcc
     1621 cgccgctgat gtccccgcac atgggcgccc actaccgtga ctgccaggga ctgggcgcac
     1681 ccgcgctcga cggctaccct ctgcccactc cggacacatc cccgttggat ggcgtggagc
     1741 aggacccggc tttctttgct gccccgctgc caggggactg cccggcggcc ggagcctaca
     1801 cgtatgctca ggtctcggac tatgcggtgc ccgcagagcc gtccgctggc cccatgcgag
     1861 tgggacccga cccctccggc tctgcgatgc cggggatcct ggcgcccccc agtgctctgc
     1921 acctgtacta cggcgcgatg ggctcgcccg cggcaagcgc cgggcgcggt ttccacgctc
     1981 agccccagca gccactgcaa ccgcagccac cgccgccacc accaccgcct ccaccgccgc
     2041 agcagcaccc gacgcacggt ccggggcagc cttctccacc tcccgaggct ctgccctgcc
     2101 gggatggcac ggaacccaac cagcccactg agctactagg ggaggtggac cgcacggaat
     2161 tcgaacagta tttgcacttt gtgtataagc cggagatggg tcttccctac cagggacacg
     2221 actgcggtgt gaacctctcg gacagccacg gagccatttc ctccgtggtg tccgacgcta
     2281 gctcagcggt ctactactgc aactaccctg acatctgacg gttgccgatt tgacctgcgg
     2341 gccagaagca gtgttacaca cttcctggaa gcgctaagga aatccttagc gtcacgctgt
     2401 tttgttttta agttgccttg gcatataatt tatggtaatt tattttgtct gccacttgaa
     2461 cagttgaagg gctacatgag attctcattt caaatgcctc gaggggtttg ctccccacca
     2521 tcactgtcca gttttagcca gtttttaata tctcaccaac ttgatccaaa gaaattttgt
     2581 cacgatctta aaaaaatcct ggaatctttt ttaaaaaaat ctctatcaca ttggttttat
     2641 caaagtaatt taaagatcaa cagtaaatat tacacaatta gaagtgtata gttaattgta
     2701 aactttctat tttcttacaa aatttaagaa accctaaata caaacagtgg ggtgttcaga
     2761 tgtgatatcg ttgttctcct acgaaaaaaa ttctcacaga atgaacttgc tatgtacatt
     2821 ccaaaatatt ggtttctaaa aataatactg taaatgtttt taattctgta tactttaata
     2881 aggctgttca aaaattctgg tttttttttt tgtcatcttg atatctgcca aaagagcttt
     2941 tcagatatat ctgttttcgt ttgtgttttc ttccaaatgt ctttatccct ttccccacaa
     3001 aatttgcctt taatccccac atttttagag tcagagaaac taatcaaaat aaaatttgtt
     3061 gtgactgtta a
//
LOCUS       NM_001436723            2844 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22),
            transcript variant 2, mRNA.
ACCESSION   NM_001436723
VERSION     NM_001436723.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360194.1993361.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760393, SAMN09345238 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               JAXUCZ010000016.1  8482449-8482715
            268-427             JAXUCZ010000016.1  8482820-8482979
            428-627             JAXUCZ010000016.1  8535616-8535815
            628-715             JAXUCZ010000016.1  8564932-8565019
            716-844             JAXUCZ010000016.1  8611088-8611216
            845-1052            JAXUCZ010000016.1  8626516-8626723
            1053-1185           JAXUCZ010000016.1  8630072-8630204
            1186-1259           JAXUCZ010000016.1  8630924-8630997
            1260-1381           JAXUCZ010000016.1  8631987-8632108
            1382-2267           JAXUCZ010000016.1  8634177-8635062
            2268-2844           JAXUCZ010000016.1  8637247-8637823
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2844
                     /gene="Arhgap22"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
     exon            1..267
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            268..427
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Arhgap22"
                     /note="upstream in-frame stop codon"
     CDS             376..2496
                     /gene="Arhgap22"
                     /note="isoform 1 is encoded by transcript variant 2; rho
                     GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22 isoform 1"
                     /protein_id="NP_001423652.1"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
                     /translation="MLPAASSKRRTFASRYFTRSKSLVMGEQSRSPGRPLAPHKLGPV
                     LKAGWLRKQKSIMKNWQQRWFVLRGDQLFYYKDKDEGKPQGFISLQGTQVTELLPDPD
                     DPGKHLFEITPGGAAEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFG
                     QRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDC
                     GEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELA
                     KQVSNLPQANYNLLRYICRFLDEVQAHSDVNKMSVQNLATVFGPNILRPQVEDPVTIM
                     EGTSLVQHLMTVLIRKHGQLFATPSFEEPASPRGTVQGTVEWGSEEVTRDHQGEPGSS
                     GLPTHRTSSLDGPAAAVLSRTSPPRLGSQAGPAATSPGKRMHTLPGWKSSFRQQGSRS
                     ESPKGVSSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPP
                     SSHLSSTASVASTAWSVASSSREASIGSCTACRASNSSACSSLHTEWALEPSPLPSSS
                     EGHPSPDLGHSLDEACVGSGSSEPNDPGSPSQAHVRRCRALQGQVAELRAELCHQRIE
                     YQRSLKSIEEGNSDLRKQMCRLEEELDQEKKKYAMLEIKLRNSERAREDAERRNQLLQ
                     REMEEFFATLGSLTAGTKGARAPE"
     misc_feature    499..846
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    499..846
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    844..1440
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    844..1440
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    order(976..978,1087..1089,1099..1101,1312..1314,
                     1321..1326,1396..1398)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    order(976..978,1087..1089,1099..1101,1312..1314,
                     1321..1326,1396..1398)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    976..978
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    976..978
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    <1489..>2436
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1489..>2436
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <2167..>2439
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <2167..>2439
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            428..627
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            628..715
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            716..844
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1052
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1185
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1259
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1381
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2267
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2844
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatggacca caagccccag gggccataat gtgtgccagg ggctgccagc acgctcagaa
       61 caatctgcac acgttgttcc cttacttagc tccatgttgt ttcctcaagt ctagtggcta
      121 gagcccatgg ctcccagagc cttcgctcct gcggatgaat ctgtcatctc caccctctga
      181 gacgcggtcg tgtcactgct ggtcccattt cacagatttg aggaactgat actctgactt
      241 ctccacttct gctctcaaat ccccatgatg ctgatcgccc gctgctgaaa ccgggaatta
      301 gctcgtctct ctgaggatgt ggctgctgcc ttccagagaa gatacaggag aaatctgcac
      361 gctgccagct tagagatgct gccggcggct tccagcaaaa gaagaacctt cgcctccaga
      421 tacttcactc gctccaagag cctggtgatg ggggaacaga gccggagccc agggaggccc
      481 ctggcccccc acaagctggg ccctgtactc aaagccggct ggctgaggaa gcagaagagc
      541 atcatgaaga actggcagca gcggtggttt gtgctgcgtg gggatcagct cttctactac
      601 aaagacaaag atgagggcaa gccccaggga tttatttctc tacaagggac acaagtgact
      661 gagcttcttc cagaccctga cgacccagga aagcacctgt ttgagattac accaggcggt
      721 gccgcagagc gggagaaggt gccagccaat cctgaggcgc tcctgctcat ggccagctcc
      781 cagcgtgata tggaggactg ggtgcaggcc atccgccgag tcatctgggc cccgctgggc
      841 ggagggatct ttgggcagcg actggaggac acagtgcacc atgagcggaa gtttggtccc
      901 cggctggcac ctctgctggt ggagcagtgt gtggacttca tccgggagcg aggactcagt
      961 gaagaggggc tcttccgtat gcccggccag gccaacctgg tgagggacct gcaggattcc
     1021 ttcgactgtg gggagaagcc gctgtttgac agcaccacag acgtgcacac agtggcctcc
     1081 ttgctgaagc tctaccttcg ggagctcccg gagccggtca tccctttcgc caggtatgag
     1141 gacttcctca gctgcgccca gctgctcacc aaggacgagg gggaggggac cgtggagttg
     1201 gcgaaacaag tgagcaacct tcctcaggcc aactacaacc tgctcagata catctgcagg
     1261 tttctggatg aagtgcaggc ccactcagac gtcaacaaga tgagcgtcca gaacttggca
     1321 actgtctttg gccctaacat cctccggcca caggtggagg atccagtcac catcatggaa
     1381 ggcacatctt tggttcagca tctgatgact gtcctcatcc gaaaacacgg acagctcttt
     1441 gccacgccct cctttgaaga acctgcttca ccacgtggta ctgtccaggg cacagtagag
     1501 tggggctctg aagaggtcac cagagaccac cagggcgagc ctgggagctc tggcttgccc
     1561 acacacagga cttcctctct ggatgggcca gctgcagcag tgctctctag aacttctccg
     1621 ccacgccttg gcagccaagc cggccctgcg gccaccagcc ctgggaagag gatgcatact
     1681 ttgcctggct ggaagtcttc ttttcggcag caggggtccc ggtcagagag cccaaagggg
     1741 gtcagctcat ccttagaggt acccatcatc tcctctggtg ggaactggct cataaacggg
     1801 ctatcgtctc ttcgcagcca ccgtcgggcc tcatcagggg accggcttaa ggatacaggc
     1861 tcagcacaga gactctccac ctatgataac gtgccaccat ccagccacct ttctagcact
     1921 gccagcgtgg ccagcacggc atggtctgta gcctcatcct cccgagaggc ctccatcggc
     1981 agctgcactg cctgccgggc cagcaactct tctgcctgca gctccttaca cactgagtgg
     2041 gcactcgagc cctctcctct ccccagcagc agtgagggcc acccgtcccc ggacctgggc
     2101 cacagcttgg atgaggcatg tgtgggcagt ggcagcagtg agcccaatga cccgggcagt
     2161 ccctcacagg cccatgttcg ccgctgccgg gctctccagg gccaggtggc cgagctcagg
     2221 gcggagctgt gtcaccagag gattgagtac cagaggagcc tgaaaagcat cgaggagggc
     2281 aattctgacc tgcggaagca gatgtgtcgg ttggaagagg agctggacca ggagaagaag
     2341 aagtatgcca tgctggagat caagcttcgg aactccgagc gagcacgtga ggacgcagag
     2401 cgcaggaacc agttgctgca gagggagatg gaggagttct tcgccaccct gggaagcttg
     2461 actgctggga ccaaaggggc cagagcccca gagtgaaagg agcggaagcg catgtccacc
     2521 tatgtccact cactttccct gcagggctgg ccacaggctg cagaggaagc cgggagcttc
     2581 aagtttgggc caggccacca gcagggtcat ctgcctccaa gtgccagata gagaggggcc
     2641 tgacgccaga atgggtactg tcaggatccc acatagtcca ggcaggatct ggatacttct
     2701 ccacacatac gggtcccagg aggtgtcagg ggcgatggtg ccaagatcat gagcatcagc
     2761 ctctcctcca ggaagagtca gtccccagtg gccacctgga gagccaggcc accgccaaga
     2821 actattaaat gtgctctgaa agca
//
LOCUS       NM_001107921            6829 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus caspase 8 associated protein 2 (Casp8ap2),
            transcript variant 2, mRNA.
ACCESSION   NM_001107921 XM_001063464 XM_232860
VERSION     NM_001107921.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6829)
  AUTHORS   Wu,T.Y., Leng,Q. and Tian,L.Q.
  TITLE     The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy
  JOURNAL   Cytogenet Genome Res 161 (3-4), 132-142 (2021)
   PUBMED   33882492
  REMARK    GeneRIF: The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy.
REFERENCE   2  (bases 1 to 6829)
  AUTHORS   Li,K., Pan,J., Li,Q., Li,S., Li,K., Cheng,Y., Chai,L., Li,C.,
            Li,J., Fu,Z., Wang,D. and Bai,Y.
  TITLE     The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury
            in Myocardial Cells by Regulating Apoptosis and Autophagy
  JOURNAL   Heart Surg Forum 23 (6), E797-E802 (2020)
   PUBMED   33234216
  REMARK    GeneRIF: The MicroRNA-210/Casp8ap2 Pathway Alleviates
            Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis
            and Autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6829)
  AUTHORS   Li,T., Song,X., Zhang,J., Zhao,L., Shi,Y., Li,Z., Liu,J., Liu,N.,
            Yan,Y., Xiao,Y., Tian,X., Sun,W., Guan,Y. and Liu,B.
  TITLE     Protection of Human Umbilical Vein Endothelial Cells against
            Oxidative Stress by MicroRNA-210
  JOURNAL   Oxid Med Cell Longev 2017, 3565613 (2017)
   PUBMED   28367268
REFERENCE   4  (bases 1 to 6829)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   5  (bases 1 to 6829)
  AUTHORS   Kim,H.W., Mallick,F., Durrani,S., Ashraf,M., Jiang,S. and
            Haider,K.H.
  TITLE     Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2
            and their role in cytoprotection during ischemic preconditioning of
            stem cells
  JOURNAL   Antioxid Redox Signal 17 (8), 1053-1065 (2012)
   PUBMED   22482882
  REMARK    GeneRIF: The ischemic preconditioning (IPC) enhances stem cell
            survival via the combined participation of hypoxia responsive miRs
            miR-107 and miR-210 via their respective putative target genes
            Pdcd10 and Casp8ap2.
REFERENCE   6  (bases 1 to 6829)
  AUTHORS   Kim,H.W., Haider,H.K., Jiang,S. and Ashraf,M.
  TITLE     Ischemic preconditioning augments survival of stem cells via
            miR-210 expression by targeting caspase-8-associated protein 2
  JOURNAL   J Biol Chem 284 (48), 33161-33168 (2009)
   PUBMED   19721136
  REMARK    GeneRIF: Data identified FLICE-associated huge protein
            (FLASH)/caspase-8-associated protein-2 (Casp8ap2) in (PC)MSCs as
            the target gene of miR-210.
REFERENCE   7  (bases 1 to 6829)
  AUTHORS   Smith,A.J., Karpova,Y., D'Agostino,R. Jr., Willingham,M. and
            Kulik,G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6829)
  AUTHORS   Milovic-Holm,K., Krieghoff,E., Jensen,K., Will,H. and Hofmann,T.G.
  TITLE     FLASH links the CD95 signaling pathway to the cell nucleus and
            nuclear bodies
  JOURNAL   EMBO J 26 (2), 391-401 (2007)
   PUBMED   17245429
REFERENCE   9  (bases 1 to 6829)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J Biol Chem 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   10 (bases 1 to 6829)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001107921.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000005.1  51810971-51811251
            282-364             JAXUCZ010000005.1  51819117-51819199
            365-433             JAXUCZ010000005.1  51824615-51824683
            434-534             JAXUCZ010000005.1  51825356-51825456
            535-609             JAXUCZ010000005.1  51826025-51826099
            610-725             JAXUCZ010000005.1  51828889-51829004
            726-2920            JAXUCZ010000005.1  51833247-51835441
            2921-6041           JAXUCZ010000005.1  51837496-51840616
            6042-6141           JAXUCZ010000005.1  51843874-51843973
            6142-6227           JAXUCZ010000005.1  51844824-51844909
            6228-6829           JAXUCZ010000005.1  51848025-51848626
FEATURES             Location/Qualifiers
     source          1..6829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..6829
                     /gene="Casp8ap2"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
     exon            1..281
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..364
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    292..294
                     /gene="Casp8ap2"
                     /note="upstream in-frame stop codon"
     CDS             310..6198
                     /gene="Casp8ap2"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001101391.1"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
                     /translation="MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDST
                     ARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEYGKCQQQMKDLMKRFKEIQTQNL
                     NLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
                     KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTN
                     NVWSRSPYQVSEGNSNEDNRRGRNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAAS
                     RLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKETSRERPHTRVEPQND
                     KNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMK
                     YYGFNKYHPEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQW
                     ENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTANGKRQT
                     EQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLSPAKKQP
                     VCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSAT
                     SQPRTSIPENKVKEENRLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEV
                     EETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDINSCDISEGGKKKVVLSPKAA
                     AASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPS
                     PQKTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSM
                     ESSCTIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVD
                     ELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTVHVHKDNGRTVVK
                     LPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKH
                     VRKNYMKFKIKFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESN
                     LKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVKHENDSS
                     EGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKHQDQN
                     KTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQ
                     HACVKSERGFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELK
                     TPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNWSLLSSEKGPSLSSGLSLP
                     VHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGH
                     LSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTS
                     RSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGMVAEESLTPLPRT
                     GKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQTQVPDIYEFL
                     KDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTK
                     DPATETKSLELMDVTVLDIDHLEHSKPNLDQDAQITCTSLQHDAVDAFIDLTHDVSNE
                     SKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGKVNSSLECTVEETCIDLTSESAGSF
                     EVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKTKR
                     LSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIK
                     KKGEIIVSWTRNDDREILLECQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEK
                     SKCR"
     misc_feature    <517..735
                     /gene="Casp8ap2"
                     /note="Afadin- and alpha -actinin-Binding; Region: ADIP;
                     pfam11559"
                     /db_xref="CDD:463295"
     misc_feature    <517..735
                     /gene="Casp8ap2"
                     /note="Afadin- and alpha -actinin-Binding; Region: ADIP;
                     pfam11559"
                     /db_xref="CDD:463295"
     misc_feature    5995..6189
                     /gene="Casp8ap2"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     misc_feature    5995..6189
                     /gene="Casp8ap2"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     exon            365..433
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..534
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..609
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..725
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2920
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..6041
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6042..6141
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6142..6227
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6228..6829
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacagcggc cgctgtgcgg ggctggccgg ccgggtaagt tcctgagggc ctgtcgcggg
       61 gctgctgggg agaggcagcg gggtgccgcc tgggatggct tgcgccgtgg gcgaagggtt
      121 gtgcctggct gggcctcaag gagccagctg ctgtcctcgg ggaccgccct ttggagagtc
      181 tcgaggggct ctggggcgag cacacggagc atcgcccggt ctacactgcg cccctcccct
      241 cccccacccg tgtctcctag gtccctactt ccgagctttt gatggcacct atgaaaagga
      301 tataggacca tggcagcaga tgatgacaat ggtgatggaa cgggtttgtt tgatgtctgt
      361 cctgcctctc ctcttaaaaa taatgatgaa ggctcattgg acatatatgc tgggttggac
      421 agtactgttt ctgacagtac tgctaggtcc tgcgtgtcgt tcagaaactg tctggatttg
      481 tatgaagaga tcctgactga agaaggaact gcaaaggagg caacatacag tgacttgcag
      541 atagaatatg ggaaatgtca gcagcaaatg aaagatctga tgaaaagatt taaggaaata
      601 cagacacaga acttgaactt aaaaaatgaa aaccagtctc ttaagaagaa tatctcagca
      661 cttatcaaaa ctgccagagt ggagataaac cgtaaggatg aagagataaa tcatcttcac
      721 caaagattgt ctgagtttcc acattttcga aataaccata aaactgcaag aacaaaagat
      781 tcacgatcca aatctcccca tttggacaat tgttcaaaga ctgatcatgg agttaaaagt
      841 gatgttcaga aagatataca tcctaacact tcacaaccaa acttggaaaa ggaagggaaa
      901 tcacattctg aagcacagaa ttctttgcac ttgtctacgg gtattgagaa acattgtaca
      961 aacaatgtct ggtcacgttc tccttaccag gttagtgaag gtaactcaaa tgaagataat
     1021 agaagaggaa ggaatggcgt cagacatagc caaggtagca gaggaactga cagaacacag
     1081 aaagacttga atagcagctg taatgatggc gagccaaggg acaaagaggc tgcttccaga
     1141 ctacacggaa accctgagaa acatggaagc agtgaagcaa gggctgagaa caaaatttca
     1201 gagattaaaa gtagcactgg tttgggaaat aaaagcgagc gcagtgcctc ttcttgggaa
     1261 aaagaaactt ccagagaaag gccacatact cgagtggaac ctcaaaatga caaaaatcta
     1321 gagagacaaa atgaaagatt acaaaataca cacagaaaag agcttcagtc tcaggacaaa
     1381 gcagaaagaa aaggtgatgt gaagtttaaa ccagcaggag aggagcaggg gcatcgggga
     1441 agagtggacc gtgcattacc tcctcattcc aagaatgaca tgaaatatta tggcttcaat
     1501 aagtatcatc cagaagagag aaggggaagg gaagatggta aacgagacag aggcatgagc
     1561 agtcatggct ttcaagatag aagatgttca tcttctcttt caagcaacag aaatagcaaa
     1621 tacccacact ccaaggaagt cagtgttgca caccagtggg aaaatacacc tttcaaagca
     1681 gaaagacata gaactgagga caggaggaaa agagaacgag aaaacaaaga agaaagtaga
     1741 catgtgaaaa gtgacaaaaa atcacctcca gaacacttgc aaaggactca taaagacact
     1801 aagaaaagta ctgctaatgg aaagagacag acggagcaga aacacggtaa aggtccagtc
     1861 tctaccagcg agctttctaa agggacagac aatagagagt gtacaatgaa agtggagaat
     1921 gggccaaatg aagcaaaggg caaggactta aagttaagct tcatggagaa gctgaactta
     1981 actctttctc ctgctaaaaa gcagcctgtt tgtcaagata acgagcatca aataattggt
     2041 gttcccaagc ccagtggcgt gtgtgactca cagtccttgg agaagactga aacagtggca
     2101 tgtcttcctt ctgtcagtga acaagataga gaggaaccca aatcagagtt accagagcca
     2161 aaggaggctc tttcagcaac atctcaaccc aggaccagca ttccagaaaa taaagtgaag
     2221 gaagaaaata gattgttatt taaatctgtt gagaatactg tgccttgtga actgcttgct
     2281 tgtggcacgg aaatttcctt cccagcacct gtagaaattg agcaagcaag atgtttggtc
     2341 caatcaatgg aagtggaaga gacatgtgct ggtgcaaggg cagctgcttc tgtggtgatg
     2401 cgtgtattac cagaacatgc ttctgaagac ttcagccaag aattgggcac caaaagacat
     2461 gatgatataa attcgtgtga tatttctgaa ggtgggaaaa aaaaggtggt tctttcacca
     2521 aaagcagcag cagccagtga gagccatctg gagcctgtgg ttgaagaacc tagcatttca
     2581 ccagtaaact gttcgggaga caataatcct aaacttgaac cttctcttga agagagacct
     2641 aaggttgaga ataaatcttc tcctttggag ccttgtttac ctaaagagat gtttgtacct
     2701 tcaccacaga agactgagtt gattgaccac aaaatagata ctggagaatc aaactcggta
     2761 tatcaagatg atgataactc agttttgagt attgacttta ataatttgag acctattcca
     2821 gaacccatca gccctctgaa tagtccagtg agaccggtat ccaaagttct tagcatggag
     2881 agctcatgta caattccact gtatgatagc agccataaag atgagtttcc atccaattca
     2941 actctttcta ccttcaagag tcagtctgat ctaaataagg aaaatgaaaa accagttccc
     3001 aaattggaca aatgttcaga agcagaatcc tgtaagaatt tgtctgtaga tgaattagaa
     3061 gaaggggaaa ttagaagtga tgatgaagaa tctgtagcac aaaagcgttt ggaaaagagt
     3121 gcaagaccca gaacttctac tgaagtgccg ccaggtaaaa tcagcccagg aagcaggagg
     3181 agcactgtgc atgtgcataa ggataacggg aggacagttg taaaactccc tcgggacaga
     3241 atcacatgga gccaaagatc aaatgaatct agaccctcaa acaccgaaag gaaaagtaaa
     3301 acaatgagca tctccagctt ggaaaaaata cttccgctta ttcttgcacc ctcctccgta
     3361 tgggaagtta tgcatatgtt acggttgcta ggaaaacatg taaggaaaaa ttacatgaaa
     3421 ttcaagataa aattttcatt gacacaattt catagaatta ttgaatcggc aattttgagt
     3481 ttcacatcac taattagata ccttgatttg tctaagatct gtaaatcagt aagtacttta
     3541 cagaagagtc tttgtgacgt tatagaatct aaccttaaac aagtgaagaa gaatggcata
     3601 gttgaccgtt tatttgaaca acaacaaaca gatatgaaaa aaaaattgtg gaagtttgtg
     3661 gatgaacaac ttgattattt gtttgaaaaa cttaaaaaaa tcctactaaa gttttgtgat
     3721 tctgtaaagc atgaaaatga cagtagtgaa ggaaaacttg gaaaaaaata taaagagaga
     3781 gcccaacatt caaattgtca gaagaagaaa atggacaaca aagaaatacg gagagaaaaa
     3841 gtgctaaaat cagaaaatac tgtgaatttt aaatcttcac tggggtgtga aaaatttgaa
     3901 gaaaaacatc aagaccaaaa taaaaccaat actactacag taaagcatga tgtgaaaaga
     3961 acttttagca cttgcactga taataataca aagaactctg aatgtaaaga gcagtttctg
     4021 ggaatgaact gcccgagtac ccccaggcca ggagaaactg aaggcaatgt ggaggagggg
     4081 acaccggcgg cacagcacgc ctgcgttaag tcagagcggg gctttgagat cctcaccgag
     4141 cagcaggcgt ccagccttac ttttaactta gtgagtgacg cacagatggg tgagatattt
     4201 aaaagtttgc tacaaggttc tgatctgttg gacacaggtg gcactgaaaa agcggagtgg
     4261 gaattaaaga ctccagagaa acagctgcta gagagcctca agtgtgagtc tgcaccagct
     4321 tgtacaacag aagagctagt ttcagaggcg gcttctctct gtccaaaggt gatcagtgat
     4381 gataattggt ctttattatc atctgaaaag ggcccatctc tatcttcagg gctttcactg
     4441 ccagttcatc ctgatgtgtt agatgaaaat tgtatgtttg aagtatcttc taaccttgct
     4501 ttaagtaaag ataatgtata cagctcagaa aagagtaagc cctgcatttc ttccatactc
     4561 ttagaagatc ttgcggtctc tttaacagta ccgtcacctc tgaagtcaga tggccatttg
     4621 agtttcttaa agcctgaagt tttgtcaact tcaactcctg aagaagttat tagtgcacat
     4681 tttagtgagg atgctttgct tgaggaagag gatgcatctg aacaggacat tcacttagct
     4741 ctagagtctg ataactcaag cagtaagtca agctgttcct catggacaag ccggtctgtt
     4801 gcttcaggct ttcagtacca ccctaatctt cccatgcatg ctgtcattat ggaaaagtcc
     4861 aatgatcatt tcattgtgaa aatacggcgt gcaacaccat ctacctcccc tggccttaaa
     4921 catggtatgg tagctgagga gtcgttgaca cctttgccta gaactggaaa agaagctgat
     4981 ggggcagcag agaaagaacc taccctgttt cagagtacag ttttaaaccc tgtccaagac
     5041 ttggaaaatt ccgacaaaag tattgataag agcaaaccaa ctcatgaaga tcagaactct
     5101 atagtacaaa cacaggttcc agatatatac gaatttctta aagatgcttc aaataaggtg
     5161 gttcattgtg atcaagtggt tgatgattgc ttcaagttgc atcaagtatg ggaaccaaaa
     5221 gtttctgaga gccttcaaga attgccttca atggaaaaaa atgcacactc tgttgatgat
     5281 catcttccta atacacacat agatctaaca aaagatccag ctactgagac taaaagcttg
     5341 gagctaatgg atgtaacagt tttagatatc gatcacttgg aacattctaa acccaactta
     5401 gatcaagatg cacagataac gtgtacttcg ttacagcatg atgctgtaga tgcttttatt
     5461 gatttgacac atgatgtttc aaatgagagt aaaaacgaaa gtaatgaacc tgtgttaact
     5521 gttgaaggtg tgggatgcca ggtaatatgt atagatgacg ataaccacaa agaaggaaaa
     5581 gtggggaagg taaacagttc cttagaatgt actgttgagg aaacctgtat tgacttgacc
     5641 tcagagtctg ctggctcctt tgaagtaaag agacacactt taaagtcaga gcctccatca
     5701 aagtcggatt gtttagagtt gcctgagact ctggggaatg gtcacaagaa gagaaagaac
     5761 agtcctgctg tgagtcactc ttctcagaaa aagcaaagaa aggacatgga cttaagtagt
     5821 gaaaagacca agagacttag tcctaattct gatagaactg gtgatgctca cagaaagcat
     5881 ggcagcaaga agagggaacc tgcagtaagt gacacatcct tgtcatcaga ggtcaaccca
     5941 gaggtgaagg gctcaacagc accacttgct acttttccag gaagcctttc tgcaaaaaat
     6001 gttatcaaaa agaaaggaga aattatagtt tcatggacaa gaaatgacga cagggaaatt
     6061 ttactggaat gtcagaaaag aatgccgtcc ctgaaaacat ttacccactt ggctgtcaaa
     6121 ctgaataaaa atccaaatca ggtttcagag aggttccagc aactgaaaaa gctttttgag
     6181 aagtcaaaat gcaggtagta gtgggtccat cgcaggatgc taatgctatg agttgctgga
     6241 tttcatggtg cctcactgat aattcttcta caaagaagct tcgattcctc gtgttttaaa
     6301 tggggaacta ggtggaggtt ttgtctcagt tttggtgact agatgatcat ctaccttttt
     6361 tttactttcc tggtcattgt gcttggctta ttcagatcaa cagtctgatt cactttcctg
     6421 ttattggtca gaatatttat ttttaatcat taaaagttgt tatcaaatga aagaataaaa
     6481 gcaacctcaa tgtaatactg aaaccttagt tttgatattg gatgaaataa cttctttaga
     6541 ttttaaaaaa caattttgta gcattttaaa tgtaatgact atttagttca cctttctatt
     6601 catttttgtt tttataattg cctcattttg gaaaattgtg aaataattta aatagtatat
     6661 ttgtatatat gtataattat tgtaatgtaa aatactatga ctgtatgtgt cttgagtgta
     6721 tgtatgcaca tgaatggctt tgctagccaa agggtttttt tatctatata aaatattttg
     6781 tataaacttt cctttcagtt agtcatgtat aataaaaaca tgtaaagtc
//
LOCUS       NM_001436732            1715 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 2, mRNA.
ACCESSION   NM_001436732 XM_006239172
VERSION     NM_001436732.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006239172.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.31168.1,
                                           SRR26360181.2822609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  156720091-156720192
            103-174             JAXUCZ010000005.1  156741558-156741629
            175-264             JAXUCZ010000005.1  156766717-156766806
            265-386             JAXUCZ010000005.1  156784207-156784328
            387-500             JAXUCZ010000005.1  156788909-156789022
            501-642             JAXUCZ010000005.1  156806838-156806979
            643-759             JAXUCZ010000005.1  156807266-156807382
            760-825             JAXUCZ010000005.1  156813995-156814060
            826-902             JAXUCZ010000005.1  156814589-156814665
            903-1715            JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1715
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..102
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..990
                     /gene="Capzb"
                     /note="isoform 2 is encoded by transcript variant 2;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 2"
                     /protein_id="NP_001423661.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MMHPSRRSLPFPLNCQLVRVGTADYGGAADQTMCINQVEQSEGF
                     TWQDGRSEMNSSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLK
                     IARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQ
                     YRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRT
                     AHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMEN
                     KIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC"
     misc_feature    202..888
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    202..888
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     exon            103..174
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            175..264
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            265..386
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            387..500
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            501..642
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            643..759
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            760..825
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            826..902
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1715
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctggaca tgatgcatcc tagcaggcgc agccttcctt tccccctgaa ctgtcagctt
       61 gtaagggttg gaactgctga ttatggaggt gccgctgatc agaccatgtg catcaaccaa
      121 gtggaacagt ctgagggctt cacgtggcaa gacggacggt ctgaaatgaa ctctagcgat
      181 cagcagctgg actgcgcctt ggacctgatg aggcgcctgc ctccacagca gattgagaaa
      241 aacctcagcg atctgatcga cctggtcccc agtctgtgtg aagatctcct gtcttctgtt
      301 gaccagcccc tgaaaattgc cagagacaag gtggtgggca aggactacct tttgtgtgac
      361 tacaacagag acggggactc ctataggtca ccatggagta acaagtatga ccctcctttg
      421 gaagatgggg ccatgccatc tgctcggctc agaaagctgg aggtagaggc caacaatgcc
      481 ttcgaccaat accgagacct gtattttgaa ggtggtgtct catcagtcta cctctgggat
      541 ctcgatcatg gctttgctgg agtgatcctc ataaagaagg ctggggatgg atcaaagaag
      601 atcaaaggct gctgggattc catccacgtg gtggaagtgc aggagaagtc cagtggccgt
      661 actgcccatt acaagttgac ctccacagtg atgctatggc tgcaaaccaa caaatccggc
      721 tcaggcacca tgaacctggg aggcagccta accagacaga tggagaagga cgaaactgtg
      781 agtgactgtt ccccacacat agccaacatt gggcgcctgg tggaggacat ggaaaacaaa
      841 atcagaagca cgctgaatga gatctacttt ggaaaaacaa aggacatcgt caacgggctg
      901 aggtctgtgc agacgtttgc agacaaatca aagcaggaag cccttaagaa tgacctggtg
      961 gaagccttga agagaaagca gcagtgttaa agacctgctt cacgctaacc ggacacgcca
     1021 tgcactcgtt aggttccttt ctttagaaaa ctcgttttct gctccttttc cctcttcctt
     1081 tccctccctg acggtcacat aacagtttgc atcgaccacg cagcgccatc tctcccccaa
     1141 aataaagtcc aataaccacc ctctggctcc aaggcctgct tcccacgacg tttccataga
     1201 gaccgtgtgg ctttgttcgc ctgtcccctt ccttcccttg cccgtttgta ggcacaggcg
     1261 cactgtctga catcctccct ccgtcttttt gttacattgg tgtaaaaaat gtaaaacaaa
     1321 aaaattttat gaactaactg gtgtgtgaaa gaagggaaac tggagctctg atccgtgtgt
     1381 gtttgggggt tgcttggagc cgggggccgg gggacagggg acagctatgg aggaaggaga
     1441 catgtcctca gcactgtcct gcgcagagca ggtgtgccct tgtcccaagg agaccgcggt
     1501 gggggtgggg gcggggctgg cgaccgctgc tctctggcca ggtgcttttc tgtcaaattt
     1561 ttatggaatg caaaaggagt tttttgtttt attttgtttt ttgtaaagct taaacagaca
     1621 aaaaaaatct acatcttcta cttgagcctc catacttaaa aaaaaaaaag gaaaaaaaga
     1681 acaaaaaaaa taaataaaaa gaaactggga cacaa
//
LOCUS       NM_001436734            1715 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 4, mRNA.
ACCESSION   NM_001436734
VERSION     NM_001436734.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.768614.1,
                                           SRR26360181.506442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  156718904-156719005
            103-174             JAXUCZ010000005.1  156741558-156741629
            175-264             JAXUCZ010000005.1  156766717-156766806
            265-386             JAXUCZ010000005.1  156784207-156784328
            387-500             JAXUCZ010000005.1  156788909-156789022
            501-642             JAXUCZ010000005.1  156806838-156806979
            643-759             JAXUCZ010000005.1  156807266-156807382
            760-825             JAXUCZ010000005.1  156813995-156814060
            826-902             JAXUCZ010000005.1  156814589-156814665
            903-1715            JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1715
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..102
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..990
                     /gene="Capzb"
                     /note="isoform 4 is encoded by transcript variant 4;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 4"
                     /protein_id="NP_001423663.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MTMCINQVEQSEGFTWQDGRSEMNSSDQQLDCALDLMRRLPPQQ
                     IEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
                     YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKK
                     AGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLT
                     RQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADK
                     SKQEALKNDLVEALKRKQQC"
     misc_feature    202..888
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    202..888
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     exon            103..174
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            175..264
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            265..386
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            387..500
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            501..642
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            643..759
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            760..825
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            826..902
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1715
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcactctt gggcacccgg ggaagtggaa gcgccgggcc ctgctgcggg ggggagagcc
       61 acagacgccg ggactgggac cgtcgccgcc gccgccacca tgaccatgtg catcaaccaa
      121 gtggaacagt ctgagggctt cacgtggcaa gacggacggt ctgaaatgaa ctctagcgat
      181 cagcagctgg actgcgcctt ggacctgatg aggcgcctgc ctccacagca gattgagaaa
      241 aacctcagcg atctgatcga cctggtcccc agtctgtgtg aagatctcct gtcttctgtt
      301 gaccagcccc tgaaaattgc cagagacaag gtggtgggca aggactacct tttgtgtgac
      361 tacaacagag acggggactc ctataggtca ccatggagta acaagtatga ccctcctttg
      421 gaagatgggg ccatgccatc tgctcggctc agaaagctgg aggtagaggc caacaatgcc
      481 ttcgaccaat accgagacct gtattttgaa ggtggtgtct catcagtcta cctctgggat
      541 ctcgatcatg gctttgctgg agtgatcctc ataaagaagg ctggggatgg atcaaagaag
      601 atcaaaggct gctgggattc catccacgtg gtggaagtgc aggagaagtc cagtggccgt
      661 actgcccatt acaagttgac ctccacagtg atgctatggc tgcaaaccaa caaatccggc
      721 tcaggcacca tgaacctggg aggcagccta accagacaga tggagaagga cgaaactgtg
      781 agtgactgtt ccccacacat agccaacatt gggcgcctgg tggaggacat ggaaaacaaa
      841 atcagaagca cgctgaatga gatctacttt ggaaaaacaa aggacatcgt caacgggctg
      901 aggtctgtgc agacgtttgc agacaaatca aagcaggaag cccttaagaa tgacctggtg
      961 gaagccttga agagaaagca gcagtgttaa agacctgctt cacgctaacc ggacacgcca
     1021 tgcactcgtt aggttccttt ctttagaaaa ctcgttttct gctccttttc cctcttcctt
     1081 tccctccctg acggtcacat aacagtttgc atcgaccacg cagcgccatc tctcccccaa
     1141 aataaagtcc aataaccacc ctctggctcc aaggcctgct tcccacgacg tttccataga
     1201 gaccgtgtgg ctttgttcgc ctgtcccctt ccttcccttg cccgtttgta ggcacaggcg
     1261 cactgtctga catcctccct ccgtcttttt gttacattgg tgtaaaaaat gtaaaacaaa
     1321 aaaattttat gaactaactg gtgtgtgaaa gaagggaaac tggagctctg atccgtgtgt
     1381 gtttgggggt tgcttggagc cgggggccgg gggacagggg acagctatgg aggaaggaga
     1441 catgtcctca gcactgtcct gcgcagagca ggtgtgccct tgtcccaagg agaccgcggt
     1501 gggggtgggg gcggggctgg cgaccgctgc tctctggcca ggtgcttttc tgtcaaattt
     1561 ttatggaatg caaaaggagt tttttgtttt attttgtttt ttgtaaagct taaacagaca
     1621 aaaaaaatct acatcttcta cttgagcctc catacttaaa aaaaaaaaag gaaaaaaaga
     1681 acaaaaaaaa taaataaaaa gaaactggga cacaa
//
LOCUS       NM_001436748            3937 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 1, mRNA.
ACCESSION   NM_001436748 XM_006252575
VERSION     NM_001436748.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3937)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006252575.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.57974.1,
                                           SRR26643297.46191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               JAXUCZ010000016.1  2308404-2308705
            303-396             JAXUCZ010000016.1  2343846-2343939
            397-463             JAXUCZ010000016.1  2401572-2401638
            464-526             JAXUCZ010000016.1  2454533-2454595
            527-634             JAXUCZ010000016.1  2546487-2546594
            635-805             JAXUCZ010000016.1  2562094-2562264
            806-868             JAXUCZ010000016.1  2566684-2566746
            869-965             JAXUCZ010000016.1  2568438-2568534
            966-1042            JAXUCZ010000016.1  2568687-2568763
            1043-1300           JAXUCZ010000016.1  2576216-2576473
            1301-1471           JAXUCZ010000016.1  2582072-2582242
            1472-1658           JAXUCZ010000016.1  2584906-2585092
            1659-3937           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..3937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3937
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..302
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    284..286
                     /gene="Arhgef3"
                     /note="upstream in-frame stop codon"
     exon            303..396
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2008
                     /gene="Arhgef3"
                     /note="isoform 1 is encoded by transcript variant 1; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     1"
                     /protein_id="NP_001423677.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MNQCIYRGMEEHKERPKRPRQNNFSMFPSPKAWNFRGRKRKQSA
                     QDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRNE
                     SRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGE
                     EDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDG
                     STEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKL
                     DLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGES
                     ECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTH
                     NEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQS
                     QTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSESLSQSPGTENRELRGETK
                     LEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEENV"
     misc_feature    806..1336
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    806..1336
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1376..1774
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1376..1774
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            397..463
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..526
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..634
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..805
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            806..868
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..965
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1042
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1300
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1471
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1658
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..3937
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgtcccc gcagtcaccg ctgcggccca gcagggccga gtcagcgggc gaggtaagag
       61 ccgcaggaac atcgcgtcgc ctgatcgtcc ttttacccgc tgcccctacc agagaagagt
      121 ccccatggcc actctgtggc gcgttggata gacagtgcca ctgcctgctt ctgcccgcgt
      181 ccgctcctgc cggggacccc aacttcggtc ctccgatagc tcctgggaga aagttcctgg
      241 agccacttcc gggagggagg cgccacctgt ctggggcgcg ccctgacgct ggacttgtcc
      301 aggaaagaag agctggacct ggcaagctga gtctgcagag catttcacag tgatgaatca
      361 gtgcatttac agagggatgg aggagcacaa ggaaagaccc aagcggccaa ggcagaacaa
      421 cttctccatg tttccctctc ccaaagcctg gaatttcaga gggcggaaac ggaagcagag
      481 tgcccaggat gaagatgccg tcagcctatg cagtcttgac ataagtgaac ctagtaacaa
      541 aagggtcaaa cccctttcca gagtcacatc gctagcaaac ctcatcccac ctgtgaagac
      601 cacaccgtta aagcgcttca gccaaacctt gcagcggtcc atcagcttcc gcaatgagag
      661 ccgccccgac atcctcgccc ctagagcctg gtccagaaat gccacctcct caagcacgaa
      721 gcggagggac agcaaactct ggagtgagac cttcgatgtg tgtgtcagtc aggtgctcac
      781 agccaaggag atcaagagac aggaggcaat ttttgagctt tctcaaggtg aagaggattt
      841 gatagaggac ttgaaattag caaaaaaggc ctaccatgac cccatgctga aactctcaat
      901 aatgacagaa caagagctga atcagatttt tggaacactg gactctctaa tccctctcca
      961 tgaagacctc cttagtcagc ttcgagatgt tcggaagccc gatggctcga cggaacacgt
     1021 tggtcccatc ctcgtgggct ggctgccttg tctcagctcc tatgacagct actgcagcaa
     1081 tcaagttgct gccaaagccc tgctggacca caagaagcag gaccacagag tgcaggattt
     1141 cctccagcgc tgcttagaat cacccttcag ccgcaaactc gacctctgga atttccttga
     1201 tattccccgg agccggctag tgaagtaccc tctgctcctt cgagaaatcc tgaggcatac
     1261 gccaaacgat aatccagacc agcagcacct ggaagaagct ataaacatca ttcagggaat
     1321 tgtggcagaa atcaacacca agactgggga atcggaatgc cgttattaca aagagcggct
     1381 tctttacttg gaagaaggcc agaaagattc cctgattgac agctcaaggg tcctgtgttg
     1441 tcatggagag ctgaaaaata accggggtgt gaaactccat gttttcctgt tccaagaagt
     1501 gctggtgatt actcgagctg tcacgcacaa tgagcaactc tgctatcagt tgtaccggca
     1561 gcccatccct gtgaaggacc tcactctgga agacctgcag gatggagaag tgcggctggg
     1621 tggctccctg cgtggggcct tcagcaacaa tgagagaatt aaaaacttct tcagagtcag
     1681 tttcaagaac ggatcccaaa gtcagaccca ctcactgcaa gccaacgaca ccttcaacaa
     1741 acaacagtgg ctcaactgta tccgtcaggc caaagaaacg gttctgtctg ctgccgggca
     1801 ggctggcttg cttgactccg agagcctgtc ccagagtcct ggcactgaga acagggagct
     1861 gcggggagaa acaaaacttg agcagatgga ccaatcggac agtgagtcgg actgcagtat
     1921 ggacacaagc gaggtcagcc tcgaatgcga gcggatggaa cagacagacg cttcctgtgc
     1981 aaacagtagg cccgaggaga acgtctgaca gaggctgtga ccctgccagc agcaggcccg
     2041 tgtcttacct gtacagtgtt tgtattccac acgggaacag tttggagagg cactttgtaa
     2101 tactcctgtg cctgtgttgg cctagcccct gtgtctactc cttgtcccta gcactgtaac
     2161 tgccacccag tctgtgtcag cttgcagcag cccttaccct gttgctgtat cccacaagca
     2221 tctggatgag tgcggaggaa tggaccatgt tacttcgagt tgtcctacat tcaaaacaga
     2281 aagactctct aaactactgt tgtgcatggc aaggcctttg tctcatgctt gcctagtgtt
     2341 cctctagctc tgacatagtc gctgaagtcc tggcactggg agagctctgc agaatactga
     2401 gatcgcattg aagggaaggc agaaagtctg attaaccctt ggagggaact ccagttttga
     2461 gttaattcaa ctagaaagca tgaaaagcat ctctgggggt ttctgaggtt ggatttttgc
     2521 aaaggaggaa gccttgtttt gaagcctgtg gtttcatcca gtgcaagttg aatgtgaata
     2581 atctgtgaag acctgaaaca gaggtggctt tagaaagggc caagacaaga gcagctgccg
     2641 gacaggcaag cagaggcagg aagatgcgga gttcaagaac agccttggct acttaccaaa
     2701 ttctagttca aactgaattc caccgtaaaa acaaaacaaa gctaaaagca ccagccagct
     2761 ctgaatattc agctgaagtt gggggtggat attggaggcg tttgtcatgg ccaatggctt
     2821 gccattagaa gagccctttc tagcctacaa catcaggatt gccaggacca gagaagatct
     2881 gccagggtca tgtgacccca tcagcattat gtttcatcct cctcagccac tcctcttttc
     2941 cagtggtaat agggggctgg gggataggga cacagagact gtgactgcat ccagtgactg
     3001 ttgacaaaca agagagaagg acttgggggt gagaaatgtg tcactgtcac ccaaggctcc
     3061 tgcgtgaacc acagaaattg aagttactcc ggagggtctc aagatttcct gctctgcttt
     3121 tgggcctggt tctagagcta cagacggact ggtggttaat tcccctcgag gctggtttca
     3181 ttagctctta ttaactagaa ccggctagcc aaactggaaa gttctttgtt aaagccttgc
     3241 tttacagagc aaggatgggt aaaaagacct tgagggcgtg gtggaaaaaa ccgttcacaa
     3301 actagacaga gcagcttctg caagtgtaaa tacttagagg atttgtataa aattataccc
     3361 acaccagcac tagtagtaat gattctaaat tattgccaaa aagttttttt tgtttgttgt
     3421 tgttaatttt tgcatctatc aaaagtttac agaaaagaaa gcaaaatgca aagttgtccc
     3481 tttactatgc acatgtgtcg tgcgcactga aagaagccgt gtggcaagag caaccaatag
     3541 aaaaacaagg tatatgacat tattattttt caagacctat tttgaccagt ttctaccctg
     3601 taaagcctat ttctgtattt atagttttta accatggtga aaattttttt ctattatgag
     3661 tttatttaaa accattttgt ctctcaagtt gctgatgtag cgaataaacc tgctccgggc
     3721 agacacagta ggaagctgag acggaccggg cactggacga tagagaaaag cctgaaatgt
     3781 tctctacaga gccattgtga ccagcgagtt aaggaagggt ctctgtcagg gtcagcctgt
     3841 gggaagagag tgaatgaatg ttctggtgaa atgaatactt ttgtataatg gccttaaact
     3901 tttctggaag catttcaaat aaattgcatt aagaata
//
LOCUS       NM_001436758            2504 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 3, mRNA.
ACCESSION   NM_001436758 XM_039109759
VERSION     NM_001436758.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2504)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_039109759.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.902109.1,
                                           SRR26643299.21872.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680435,
                                           SAMN06680443 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000005.1  21321991-21322144   c
            155-241             JAXUCZ010000005.1  21318760-21318846   c
            242-630             JAXUCZ010000005.1  21316424-21316812   c
            631-795             JAXUCZ010000005.1  21304734-21304898   c
            796-989             JAXUCZ010000005.1  21301659-21301852   c
            990-1050            JAXUCZ010000005.1  21296573-21296633   c
            1051-1190           JAXUCZ010000005.1  21294405-21294544   c
            1191-2504           JAXUCZ010000005.1  21291897-21293210   c
FEATURES             Location/Qualifiers
     source          1..2504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2504
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..154
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    132..134
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="upstream in-frame stop codon"
     exon            155..241
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            242..630
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1295
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform a is encoded by transcript variant 3;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform a"
                     /protein_id="NP_001423687.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAN"
     misc_feature    612..1232
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    612..1232
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(690..692,699..701,708..710,753..764,897..905)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(690..692,699..701,708..710,753..764,897..905)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            631..795
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            796..989
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1050
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1190
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..2504
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcatcc gcaactctct cggctctcgg aacggaccgc cgcagctttt tgtctgaggc
       61 taggcgtatc tcttgtctca tgacggtcca gtcccgcgag cctgatggag ctggagggaa
      121 aagtgagacc ctagtgccga ggccattggt acaggttcac ccccgctgca gcagggctct
      181 gctctctgac tgagtggtgc tgtgttacat ggatctgtca tttctattca gtcatcagtt
      241 ggcattgcag taacacctat ggcaatgaag aaagagacag aatttgggat tttcatctaa
      301 ggaaaatgat aaataacaac cagacgtgtg ctgcagggca ggactccgtg ccctacgtga
      361 cctgtatgct tcacgtgctg gaagagtggt tgggtgtgga acagttggag gactacctga
      421 attttgcgaa ccatctcttg tgggtcttca ccccgctgat ccttttaata cttccgtact
      481 ttaccatctt ccttctctac cttactatta ttttcctcca catctataag aggaagaatg
      541 tgttaaaaga agcctactct cacaacttgt gggatggcgc gaggaaaaca gtggcaaccc
      601 tgtgggatgg acatgcggcg gtttggcatg gttatgaagt tcacgggatg gaaaagatac
      661 cagaaggacc agcacttata attttttatc atggagctat tcccatagac ttttactact
      721 tcatggctaa aattttcatc cacaaaggca gaacttgccg agtggtagct gaccactttg
      781 tctttaaaat cccagggttc agtttattac ttgatgtatt ttgtgctctt catggaccaa
      841 gagaaaaatg tgttgaaatc ttgaggagtg gtcacttgtt agctatttca ccgggtggag
      901 ttcgagaagc cttacttagt gatgaaacct acaacatcat atggggtaat cgtaaaggct
      961 ttgctcaggt tgcaatcgat gcaaaagtgc ccattattcc tatgtttaca caaaacatcc
     1021 gagaaggatt tagatcactc ggaggaacaa gattgtttaa atggctttat gaaaaattcc
     1081 gctatccgtt tgctccaatg tatggaggtt ttcctgtgaa gttgcggacc ttcttgggtg
     1141 atcctattcc gtatgaccca gaggtaacag cagaagaatt agctgaaaag actaagaacg
     1201 ctgttcaagc tttgatcgac aagcaccaaa ggataccggg gaacattagg agtgctttgc
     1261 tggaccgctt tcataaagag cagaaggcta attgacagat aatttcgtgt gtctctaatg
     1321 ccaagtttgc atctgtggta ctgcctttta aacttttgta ggttgtataa tagtcttttt
     1381 aaaacctgct aatgagcatc tttctttaga atttaaactt tctatggtta atcttaccct
     1441 ttcaatcagt tttgtcaaat gtagtaagta actcaccatt tgcttgactc agaagatgat
     1501 catgttgcat ttgcaatcct tagtagtata tgataggcac aagtcttcct ggataccagc
     1561 agtctaggtt aggcagactt cactaaatta tgcttctgtg tttgtgtctg ttgtgccaat
     1621 gggatggtga gaggtacctg agctggggtg tagcacttgc ttagtttagg tgagcggtgc
     1681 ctttgtatcc atccttcatt ccactcacaa ctgctggtaa gttgtgaaac gcttttgcac
     1741 ctccgtggtt tatgttaagc atggtaatac tgtggtggtg aacattaagt tgcttatgtc
     1801 tactgtgata tatccgtatc tatatatctg atagatatct gtagtgagaa atctgtaatt
     1861 gaattgattc ctgaatcctt taggagttat gtacattttt gtttattggg tattgaaatt
     1921 actccttcag ggatgatgtc cagttgccaa gcacaatgaa agagatgtac tattttgtaa
     1981 atcaaatcat tgttatttgt agtatttatt aacagagttg tttggtattt attttaaaca
     2041 aggatctaag taaatgtata ggatggattg tcagcacgtg tcttacacgg tgtaaagata
     2101 aaatcgtggg cacgctctgc agtttatgtt agagcagatc ctaggctgag gagtgacaac
     2161 tgaggaagct ctgcctcgct tgtcccaggg ctcgcttccg tgctctgcag ccagtcacgt
     2221 ggttatatct gtaaaatgta cttgaatgat gaatttctgt aaacatggag tcctctgaaa
     2281 atgtaattac tttgaattgt tgtcttcttg aaaacttatt ttaaaagtat ttaaacagcc
     2341 aagtatcatg aattcatcgc agtgtgtctt ccccctttgc agtacttggg ttttatatgg
     2401 actttttaac tacaagtgta tatttgtgat atgtataatg tatgtataat gtatatagaa
     2461 atggtgtgaa aataaagctg aactgcaact cctctctagt aaaa
//
LOCUS       NM_001107903            2425 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 2, mRNA.
ACCESSION   NM_001107903 XM_001068973 XM_232647
VERSION     NM_001107903.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2425)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001107903.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360190.2104970.1, SRR26643299.21876.1
                                    [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN12840105,
                                    SAMN12840106 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000005.1  21322310-21322426   c
            118-162             JAXUCZ010000005.1  21317363-21317407   c
            163-551             JAXUCZ010000005.1  21316424-21316812   c
            552-716             JAXUCZ010000005.1  21304734-21304898   c
            717-910             JAXUCZ010000005.1  21301659-21301852   c
            911-971             JAXUCZ010000005.1  21296573-21296633   c
            972-1111            JAXUCZ010000005.1  21294405-21294544   c
            1112-2425           JAXUCZ010000005.1  21291897-21293210   c
FEATURES             Location/Qualifiers
     source          1..2425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2425
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..117
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            118..162
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            163..551
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1216
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform a is encoded by transcript variant 2;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform a"
                     /protein_id="NP_001101373.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAN"
     misc_feature    533..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    533..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(611..613,620..622,629..631,674..685,818..826)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(611..613,620..622,629..631,674..685,818..826)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            552..716
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            717..910
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            911..971
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1111
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..2425
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcaggtg tttaaagaaa gccggcgcta tctgagagtc cgcctctccg gggtcaaccg
       61 cggactagct gccgacgtcg ccgaggataa cctgatcttc tgtgacttcc ttgtcagagt
      121 tcatgcattg aagctagaga taggatattt gtgtacttcc tggcattgca gtaacaccta
      181 tggcaatgaa gaaagagaca gaatttggga ttttcatcta aggaaaatga taaataacaa
      241 ccagacgtgt gctgcagggc aggactccgt gccctacgtg acctgtatgc ttcacgtgct
      301 ggaagagtgg ttgggtgtgg aacagttgga ggactacctg aattttgcga accatctctt
      361 gtgggtcttc accccgctga tccttttaat acttccgtac tttaccatct tccttctcta
      421 ccttactatt attttcctcc acatctataa gaggaagaat gtgttaaaag aagcctactc
      481 tcacaacttg tgggatggcg cgaggaaaac agtggcaacc ctgtgggatg gacatgcggc
      541 ggtttggcat ggttatgaag ttcacgggat ggaaaagata ccagaaggac cagcacttat
      601 aattttttat catggagcta ttcccataga cttttactac ttcatggcta aaattttcat
      661 ccacaaaggc agaacttgcc gagtggtagc tgaccacttt gtctttaaaa tcccagggtt
      721 cagtttatta cttgatgtat tttgtgctct tcatggacca agagaaaaat gtgttgaaat
      781 cttgaggagt ggtcacttgt tagctatttc accgggtgga gttcgagaag ccttacttag
      841 tgatgaaacc tacaacatca tatggggtaa tcgtaaaggc tttgctcagg ttgcaatcga
      901 tgcaaaagtg cccattattc ctatgtttac acaaaacatc cgagaaggat ttagatcact
      961 cggaggaaca agattgttta aatggcttta tgaaaaattc cgctatccgt ttgctccaat
     1021 gtatggaggt tttcctgtga agttgcggac cttcttgggt gatcctattc cgtatgaccc
     1081 agaggtaaca gcagaagaat tagctgaaaa gactaagaac gctgttcaag ctttgatcga
     1141 caagcaccaa aggataccgg ggaacattag gagtgctttg ctggaccgct ttcataaaga
     1201 gcagaaggct aattgacaga taatttcgtg tgtctctaat gccaagtttg catctgtggt
     1261 actgcctttt aaacttttgt aggttgtata atagtctttt taaaacctgc taatgagcat
     1321 ctttctttag aatttaaact ttctatggtt aatcttaccc tttcaatcag ttttgtcaaa
     1381 tgtagtaagt aactcaccat ttgcttgact cagaagatga tcatgttgca tttgcaatcc
     1441 ttagtagtat atgataggca caagtcttcc tggataccag cagtctaggt taggcagact
     1501 tcactaaatt atgcttctgt gtttgtgtct gttgtgccaa tgggatggtg agaggtacct
     1561 gagctggggt gtagcacttg cttagtttag gtgagcggtg cctttgtatc catccttcat
     1621 tccactcaca actgctggta agttgtgaaa cgcttttgca cctccgtggt ttatgttaag
     1681 catggtaata ctgtggtggt gaacattaag ttgcttatgt ctactgtgat atatccgtat
     1741 ctatatatct gatagatatc tgtagtgaga aatctgtaat tgaattgatt cctgaatcct
     1801 ttaggagtta tgtacatttt tgtttattgg gtattgaaat tactccttca gggatgatgt
     1861 ccagttgcca agcacaatga aagagatgta ctattttgta aatcaaatca ttgttatttg
     1921 tagtatttat taacagagtt gtttggtatt tattttaaac aaggatctaa gtaaatgtat
     1981 aggatggatt gtcagcacgt gtcttacacg gtgtaaagat aaaatcgtgg gcacgctctg
     2041 cagtttatgt tagagcagat cctaggctga ggagtgacaa ctgaggaagc tctgcctcgc
     2101 ttgtcccagg gctcgcttcc gtgctctgca gccagtcacg tggttatatc tgtaaaatgt
     2161 acttgaatga tgaatttctg taaacatgga gtcctctgaa aatgtaatta ctttgaattg
     2221 ttgtcttctt gaaaacttat tttaaaagta tttaaacagc caagtatcat gaattcatcg
     2281 cagtgtgtct tccccctttg cagtacttgg gttttatatg gactttttaa ctacaagtgt
     2341 atatttgtga tatgtataat gtatgtataa tgtatataga aatggtgtga aaataaagct
     2401 gaactgcaac tcctctctag taaaa
//
LOCUS       NM_001107915            9606 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus vir like m6A methyltransferase associated
            (Virma), transcript variant 2, mRNA.
ACCESSION   NM_001107915 XM_001053130 XM_001053205 XM_232783
VERSION     NM_001107915.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9606)
  AUTHORS   Hong,H., Xu,G., Bao,G., Zhang,J., Chen,C., Chen,J., Wu,C.,
            Jiang,J., Huang,J., Huang,H. and Cui,Z.
  TITLE     VIRMA promotes neuron apoptosis via inducing m6A methylation of
            STK10 in spinal cord injury animal models
  JOURNAL   CNS Neurosci Ther 30 (3), e14453 (2024)
   PUBMED   37721438
  REMARK    GeneRIF: VIRMA promotes neuron apoptosis via inducing m6A
            methylation of STK10 in spinal cord injury animal models.
REFERENCE   2  (bases 1 to 9606)
  AUTHORS   Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
            Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   3  (bases 1 to 9606)
  AUTHORS   Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
            Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
            and Liu,J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9606)
  AUTHORS   Schwartz,S., Mumbach,M.R., Jovanovic,M., Wang,T., Maciag,K.,
            Bushkin,G.G., Mertins,P., Ter-Ovanesyan,D., Habib,N.,
            Cacchiarelli,D., Sanjana,N.E., Freinkman,E., Pacold,M.E.,
            Satija,R., Mikkelsen,T.S., Hacohen,N., Zhang,F., Carr,S.A.,
            Lander,E.S. and Regev,A.
  TITLE     Perturbation of m6A writers reveals two distinct classes of mRNA
            methylation at internal and 5' sites
  JOURNAL   Cell Rep 8 (1), 284-296 (2014)
   PUBMED   24981863
REFERENCE   5  (bases 1 to 9606)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   6  (bases 1 to 9606)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001107915.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000005.1  29758623-29758709
            88-203              JAXUCZ010000005.1  29766057-29766172
            204-290             JAXUCZ010000005.1  29769768-29769854
            291-339             JAXUCZ010000005.1  29777954-29778002
            340-508             JAXUCZ010000005.1  29782461-29782629
            509-631             JAXUCZ010000005.1  29783958-29784080
            632-904             JAXUCZ010000005.1  29784916-29785188
            905-2045            JAXUCZ010000005.1  29788126-29789266
            2046-2198           JAXUCZ010000005.1  29792616-29792768
            2199-2687           JAXUCZ010000005.1  29794315-29794803
            2688-2842           JAXUCZ010000005.1  29796379-29796533
            2843-2925           JAXUCZ010000005.1  29797906-29797988
            2926-3019           JAXUCZ010000005.1  29801477-29801570
            3020-3564           JAXUCZ010000005.1  29801711-29802255
            3565-3800           JAXUCZ010000005.1  29802767-29803002
            3801-4053           JAXUCZ010000005.1  29803600-29803852
            4054-4271           JAXUCZ010000005.1  29806594-29806811
            4272-4404           JAXUCZ010000005.1  29809114-29809246
            4405-4557           JAXUCZ010000005.1  29811502-29811654
            4558-4718           JAXUCZ010000005.1  29812069-29812229
            4719-4815           JAXUCZ010000005.1  29813736-29813832
            4816-4982           JAXUCZ010000005.1  29815947-29816113
            4983-5314           JAXUCZ010000005.1  29816841-29817172
            5315-5458           JAXUCZ010000005.1  29819674-29819817
            5459-9606           JAXUCZ010000005.1  29820557-29824704
FEATURES             Location/Qualifiers
     source          1..9606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..9606
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="vir like m6A methyltransferase associated"
                     /db_xref="GeneID:313061"
                     /db_xref="RGD:1559904"
     exon            1..87
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..5613
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="protein virilizer homolog isoform 2"
                     /protein_id="NP_001101385.1"
                     /db_xref="GeneID:313061"
                     /db_xref="RGD:1559904"
                     /translation="MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIP
                     PGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRP
                     NSKVNTDGLVLRGWYNCLTLAIYGSVDRVLSHDRDSPPPPPPPPPPPQPQPTLKRSLK
                     HADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYF
                     EPISPDRNSVPQEGQYSDEGEVEEEQQEEGEDDEDDVDVDEEEDEDEDDCHTVDSIPD
                     DDEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVP
                     PMTYDPYDRELVPLLYFSCPYKTTFEIEINRMKDQGPDKENSGAIEASLKLTELLDLY
                     HEDRGAKWVTALEEVPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVAFRQPIA
                     LNVRQLKAGTKLVTSLAECGAPGVTELLQAGVISVLFDLLFADHVSSSLKLNAFKALD
                     SVISMTEGMEAFLRSTQSEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEI
                     KRLGDHIAEKTSSVPNPSEPDHDTDAVLERANPDYENEVEASMDMDLLESSNISEGEI
                     EKLINLLEEVFHLMETAPHTMIQPPVKSFPTIARITGPPERDDPYPVLFRGPGFGFEH
                     SNSGLQPSATPVPDGPMASSGLCGHCTHMVHRHTCKQNTHNIRYLHSHHFLELVTLLL
                     SIPITSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGL
                     QSDGVDDAFALWLQDSTQTLQCVTELFSHFQRCTASEETDHSDLLGTLHNLYLITFNP
                     VGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILILVVVQSSSD
                     VQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNL
                     MTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLN
                     SILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALV
                     TLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLK
                     EVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQ
                     AKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSE
                     DKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDEKYAEIFQDLLALVRSP
                     GDSVIRQQCVEYVTSILQSLCDQDIALILPSPSEGPGSELEQLSNSLPSKELMAAICD
                     CLLATLANSESTYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTF
                     SKDTGELTSASLDFMRQILNSDAMGCCGDDSGLMEVESAHPPRTMSINAAELKQLLQS
                     KEESPESLFLELEKLVLEHSKEDDSLESLLDNVIGLKQMLESSGDPLPLSDQDVEPVL
                     SAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCC
                     SDFDLHSELERSFLSEPSSPGRAKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVV
                     PPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKR
                     PLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPR
                     GNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASTNSGSGGS
                     RGKFVSGGSGRGRHVRSFTR"
     misc_feature    37..729
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="Virilizer, N-terminal; Region: VIR_N; pfam15912"
                     /db_xref="CDD:464938"
     misc_feature    37..729
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="Virilizer, N-terminal; Region: VIR_N; pfam15912"
                     /db_xref="CDD:464938"
     exon            88..203
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            204..290
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            291..339
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            340..508
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            509..631
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            632..904
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            905..2045
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2198
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2687
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2842
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2925
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3019
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3564
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3800
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..4053
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4271
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4404
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4557
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4718
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4815
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4816..4982
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5314
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..5458
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            5459..9606
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggtcccc cgcccgcggc gaacatggcg gtggactcgt ccatggagct gctattttta
       61 gatactttta aacatccaag cgctgagcaa agttctcata tagatgtggt tcgttttcca
      121 tgtgtggttt atatcaatga agtccgagtt atacccccgg gagtacgagc ccatagtggc
      181 ttacctgaca acagagcata tggggaaaca tctcctcaca catttcaact agacttattt
      241 ttcaataacg taagcaaacc aagtgctcca gtttttgata ggttgggaag tctggaatat
      301 gatgagaata cgtctatcat ctttagacca aactcgaagg taaatactga tggtctggtg
      361 ctaagaggct ggtacaactg tctgaccctg gcaatatatg gatcggtgga tagagtgcta
      421 agccatgaca gagactctcc tccacctcct cctccacctc caccccctcc ccagccacag
      481 ccgacactga aaaggagcct aaaacacgct gatggtgaga aagaagatca gtttaatgga
      541 agtcctccaa gacctcagcc ccggggacca agaactcctc ccggacctcc tccacccgat
      601 gacgatgagg atgaccctat gtctttgcca gtgtctggtg acaaagaaga agatgttccc
      661 cacagagaag attactttga gcccatttct cctgatagga attccgtccc gcaggaaggt
      721 cagtattccg atgaggggga ggtcgaagaa gaacagcagg aagagggaga agatgatgaa
      781 gatgatgtgg atgtagacga agaagaggat gaagatgagg atgactgcca tacagtggac
      841 agtatccctg atgatgatga ggaagatgaa gaggaggagg gtgaagaaga tgaagaaggt
      901 gaaggggacg atggctacga gcagatctcc agtgatgaag atgggattgc tgacttggaa
      961 cgtgaaactt tcaagtatcc aaacttcgat gttgaataca ctccggaaga cctggcgtct
     1021 gttcctccta tgacatacga cccctatgac agggagctgg taccactctt gtatttcagc
     1081 tgcccataca aaactacttt tgaaattgaa atcaatagaa tgaaggatca gggtccagat
     1141 aaagagaatt caggggcaat agaagcttcg ttgaagttaa ctgagctgct agatctgtat
     1201 cacgaagaca ggggcgcaaa gtgggtgaca gctctagaag aagtcccaag tttaattata
     1261 aaaggattaa gctatttgca gttgaagaac acaaaacaag actcccttgg ccagttggta
     1321 gactggacaa tgcaagcttt aaatttacaa gtagcctttc gccagcccat agccttaaat
     1381 gtcagacagc tcaaagctgg gaccaagcta gtgacctcat tagcagaatg tggggctcca
     1441 ggagtcacag aattgctaca agcaggagtg atcagtgtat tgtttgatct cctatttgct
     1501 gatcatgtct catcgtccct taagttaaat gcttttaaag ctttggacag tgtcattagc
     1561 atgaccgaag gaatggaggc ctttttaaga agcacccaaa gtgagaaaag tggctatcaa
     1621 aaactgctgg agctcatact tctagatcag acggtgaggg ttgtcactgc tggctcagct
     1681 attcttcaaa aatgccattt ctatgaagtc ttgtcagaga ttaaaagact cggtgaccat
     1741 atagcagaga agacttcatc tgttcccaac cccagcgagc ctgatcacga cacagatgct
     1801 gtactggaga gagcaaaccc agattatgag aatgaagtag aagcttctat ggacatggat
     1861 ctattggaat cctcaaatat aagcgaaggc gaaatagaaa agcttattaa tcttttagag
     1921 gaggtttttc atctaatgga aactgcacct cacacaatga tccaacctcc tgttaagtct
     1981 ttcccaacaa tagcacggat tactggacct ccagagaggg atgacccata tcctgttctc
     2041 tttagagggc ctgggtttgg ttttgaacac tcaaatagtg gcttacaacc atcagctacg
     2101 ccagttccag acggtccaat ggcctcttct ggcctatgtg ggcactgtac acacatggta
     2161 cacaggcata catgcaagca gaacacccac aacataaggt atcttcacag ccatcacttc
     2221 ctggagttgg tcaccttgct tctgtcgatt ccaataacaa gtgcccatcc cggagtgctg
     2281 caagccacca aggacgtttt aaagtttctc gcacagtcac aaaagggcct tctctttttt
     2341 atgtcagaat atgaagcaac aaacttgttg atccgagctc tgtgccacct ttacgatcaa
     2401 gacgaagagg agggccttca gtctgacggg gttgacgatg cctttgcctt gtggctgcag
     2461 gactcaactc agactctcca gtgcgtcaca gaactgttca gccattttca gcgttgtaca
     2521 gccagtgagg aaactgacca ttcggatctc ctgggcaccc tccacaatct ttatttgatt
     2581 acttttaatc ctgttggaag atcagctgtt ggccatgttt tcagccttga caaaaacctt
     2641 cagagtctca ttactctaat ggagtactat tccaaagaag ccctaggtga ttccaagtct
     2701 aagaagtcag tagcttataa ttatgcatgc atacttattc tggtggtggt tcagtcttcc
     2761 agtgatgtcc agatgctgga gcagcatgca gcatctctct tgaagctttg caaagcagat
     2821 gaaaataatg ctaaactgca agaacttggc aagtggcttg aacctctgaa aaacctcaga
     2881 tttgaaatta actgcatccc aaatctaatt gaatatgtta aacagaatat tgataacttg
     2941 atgactgcag aaggagttgg ccttaccact gccttacgtg ttctctgtaa tgtggcttgt
     3001 ccaccacctc ctgtagaagg tcaacaaaaa gacctgaagt ggaaccttgc tgttattcag
     3061 cttttttctg ctgaaggaat ggacaccttt attcgggttc tgcaaaagtt gaacagtatt
     3121 ttgacacagc cttggaggct ccatgtgaac atggggacta ccctgcacag agttactacc
     3181 atttcaatgg ctcgctgcac gctcaccctt cttaaaacta tgctgacaga gctcctgcga
     3241 ggcggatcct ttgagtttaa ggacatgcga gttccttcag cactcgttac tttacacatg
     3301 ctcctgtgct ctatccctct ctcaggtcgt ttggatagcg atgaacagaa aattcagaat
     3361 gatatcattg atatcttatt gacttttaca caaggagtta atgagaagct cacaatctct
     3421 gaagagactc tggccaataa tacttggtct ttaatgttaa aggaagttct ctcttccatc
     3481 ttgaaggttc ctgaaggctt cttctctgga ctcatactcc tttcagagct gctgcctctt
     3541 cccttgccca tgcagaccac gcaggttatt gagccacatg atatatcagt ggcactcaac
     3601 acccgaaaat tgtggagcat gcaccttcat gttcaagcaa agttgctcca agaaatagtt
     3661 cgttctttct ctggcacaac ctgccagccc attcagcata tgttacggcg tatttgtgtt
     3721 cagttgtgtg accttgcctc tccaactgct cttctgatca tgagaactgt gttggatttg
     3781 attgtagaag acttgcaaag cacttcagaa gataaggaaa agcagtatac tagccaaacc
     3841 accaggttgc ttgctcttct cgatgctctg gcttcacaca aagcttgtaa attagctatt
     3901 ttgcatctaa ttaatggaac tattaaaggc gatgaaaagt atgcagagat attccaggat
     3961 cttttagctt tggtgcgatc tcctggggac agtgttattc gccagcagtg tgtggaatat
     4021 gtcacatcca ttttgcagtc tctctgtgac caggacatcg cactcatctt gccgagccct
     4081 tctgaaggtc ccggctctga gctggagcag ctttccaact ccctcccgag taaagagctg
     4141 atggctgcca tctgtgactg tctgctggcc acactagcca actccgaaag cacttacaac
     4201 tgtctgctga cgtgtgtgcg cacaatgatg tttcttgcag agcatgatta tgggttgttt
     4261 cacttaaaaa gttctttaag gaagaacagt agtgctctgc atagcttgct gaagcgagtg
     4321 gtcagcacat tcagtaagga cactggcgag cttacgtcag cgtctctgga cttcatgaga
     4381 cagatcctca actctgatgc aatgggctgt tgtggagacg acagtggtct catggaggta
     4441 gagagcgctc acccaccccg gacgatgagt attaacgctg cagagctaaa acagctccta
     4501 cagagcaaag aagagagtcc agagagtctg tttcttgaac tagagaagct cgttttggaa
     4561 cactcaaaag aggatgacag tctggagtcc ctgctggata acgtaattgg gctgaagcag
     4621 atgctggagt cttcaggtga ccctttgcct ctcagtgacc aggatgtaga gccagtcctg
     4681 tcagctccag agtctctcca gaatctattc aacaacagga ctgcgtatgt gttggctgat
     4741 gtcatggatg atcagttgaa atctatgtgg tttactccat ttcaggctga agagatcgat
     4801 acagatctgg atttggtaaa ggttgactta attgagctct cggaaaagtg ctgcagtgac
     4861 tttgacctgc actcagaatt ggagcgctcc tttttgtcag aaccgtcatc tccaggaaga
     4921 gccaagacca cgaaggggtt taaactaggg aagcataagc acgagacgtt cataacttca
     4981 agtggaaaat ctgaatacat tgaacccgcc aaacgagctc acgttgtgcc cccaccaaga
     5041 ggccggggcc ggggaggatt tggccagggc atccggccgc atgatatttt ccgtcagaga
     5101 aagcagaaca cgagtaggcc accgtctatg catgtggatg actttgttgc agccgaaagt
     5161 aaagaagtgg ttcctcaaga tggaatacct ccacccaaac ggccgctcaa ggtctctcag
     5221 aagatttcct cccgcggtgg attttcaggc aaccgaggag ggcggggtgc ttttcacagt
     5281 cagaacaggt ttttcacacc gcctgcttcg aaaggaaact acagtcgtcg ggaaggaaca
     5341 agaggctcca gttggagtgc tcagaatact ccgagaggaa attataacga aagccgaggg
     5401 ggccagagca acttcaacag gggccctctt ccgccattac ggccacttag ctccacaggt
     5461 taccgcccta gtccccggga tcgagcttct cggggccgtg gggggctcgg accgtcctgg
     5521 gccagtacaa atagcggcag tggaggctca cgaggaaagt ttgttagtgg aggcagtggt
     5581 agaggccgtc atgtacggtc ctttactcga tagacgtgct cttgggaaca ccccaagtaa
     5641 atggacattt catgaggaca aaaaacagac agaccttgaa ggaccaattt agacttagca
     5701 gttatatctg gattcatctg agagaatatt tttatctgaa gaaagcagat tttgtttgat
     5761 acttaatgag atttcaataa aaatccaaac tttgtatata tgtttgtata tatttttccc
     5821 atttttatat ggtatttatt tagaaaattt ctaggtagaa agaggaaaac taaataattt
     5881 gttttgtatt tttcttgctt atactataga tatttccaaa ctttcttcgc ctgtgacacc
     5941 ctttagtgtg tctcagggat tttttcacag tgtccctagg ccaaaagcaa acttaatact
     6001 tttgtttatt aaacagttag gtccaagcaa ccgaagactt tccaccatca ccactagtaa
     6061 ctggacacca ctcgctcaag gcctcaccct tggaaacagc agccttccct gtccgggtcc
     6121 ccgagcagta ctgtttatca cactgctgaa catttgtcac agttgtgtgc tgtcatggaa
     6181 agtcatccag tgctacccac gctgaaaatg tgaactacct caaactagta gtttgtgtgg
     6241 tccagcagat gttgctgttt cctcaaaaat tcaaaacgct catgctcatt tacgaaggtg
     6301 cccaccacac agtttagtca tcatcattgc tgcaccagaa gaagcaaaac acctccttat
     6361 gttagagaga aatgcagact ttgcttcaag tttggaccta ctgatgctat tttataacat
     6421 agttatttaa agcctaaaag ttggcttatc ctaatatggt tattttggga atcaagcatc
     6481 tactttatat tcagaaataa aacttataac tttgaccaag gagccatatt tcccccaaga
     6541 tatgtcttaa ttcattgagc ctatatacat ggcataaaat atagagttct cttaaacaaa
     6601 actaagtgta tgagtctcat tccatcccaa cagcctctgt tctggggaat cacttgagtg
     6661 catttaatat ctgtttatta ggcaaaaagg ccttgaaaag ttcagcttta gaattgaggg
     6721 tttagcttac tggtagaagt acttgcctag catgtgtgat aaccactaga agtgtgtatg
     6781 tgtgtgtctc tatgtgcacg tctttgtgta tgcacatgca tatgtgcgtg cgtgcatgca
     6841 cgcatacatg catgtgcatg gaaagttcag ccgtaaggat tctgatgctt atgtacaagg
     6901 tgatgaaaat tttcttaata gtctggaaca attcaagctc ttagtctgct cacgctgcta
     6961 taacatagtt aaatagatta gatggatagt aacaaaaatc tcttagttcc atggtcaggc
     7021 ctttggtata atcaggttct ggtgaggcac tccttgaaga tttttcacat gctctttctg
     7081 tagttgagga cctcttctat catggacaga tggtttaagg agtttgccaa cctagatttt
     7141 gaatcgtatt tctacaccat ctgaatcaag tacctacctt tctccactca tagcatcaga
     7201 atgtacctct tttgctgggc tgtagagtga atggcacatc tgtaaggagt cttgacttct
     7261 tttctcattt atttgaaccc tgcatttagg atattttcag tttgtatcag tttgtgtctg
     7321 tactgtgatg gttagtgttg tccacttgat agtatttaga attacgggag gtcctggggt
     7381 ctctggataa gccggatggg ggataattta aattaattac actgcagtag gattactagc
     7441 catcatggtt ggcacagttc cctgggtgag atcctgcctg gaccacagaa gtagagaaag
     7501 gagatgaatg ctagcaggct atgtagaatg taaggattaa ttcaccatgt agaaatagaa
     7561 ttccaaacac ctattgtgat ttgtcatttc aaaaatgagt cagatgtgca tgtacattta
     7621 gatccgtgta taactgcact tcttcagaat gagtgactat gagtgtattt tgtctcagtg
     7681 atgtatatgt ttacattaga catttcagtg gtgtcgtttg gtatttggga attaaagctg
     7741 cagaatatct ttggggacaa agttaatttc atctctagca caaatagagg ataggatcat
     7801 ttgtattcat tccataaaaa tagaaaatac taaaatactg atgggcagga ttggggattt
     7861 agttcagtgg taaagcactt gcctagcaag tacaaggccc tgggttcggt ccccagctcc
     7921 gaaaaaaaga aaaaagaagg agtttgtaaa aactgatggc ctttatttta gacttgctgg
     7981 tattagtttc agacagtaga agttcagtta ggttagtttt attgtacaaa accttgggaa
     8041 aacctccaag atgcaatcaa aagatagaac ttgtctcctg agcttgtctc aacttgtctt
     8101 ggtgccttag ttcagtcctt aatattaaag caaggtattg gcttcttttt atgctttatt
     8161 tacttattgt atgtcggtct gcgtgatgta tgggggtctg tgccacagca tgtctatgta
     8221 ggtcagaggg caacttggta gagttggcac ttcctttctg tgagttctgg ggatcaaact
     8281 caggcttggc aagctcttta cccactgagc catcttacca gcctaaagcc aggtattttc
     8341 tgcctttgcc aggaagtgta caatgtattg aagacaatga ctgcataaac agtgaactta
     8401 aaaagagaaa taataaaatc ttaggttatc agtatgaaat gacccagaat tcttaagtaa
     8461 tccaaccagt acatttcaat gtaattgtat tataggtgtt ttacagtagc taacttcaaa
     8521 atagctaaat aggtataatg ggagagcatc ttgatgtcac acttttataa tttcagacta
     8581 atatcctttt ttggaactat atatggaggc aaagatggaa aataatgcac tttttagttt
     8641 cgtaaattta ggactgggtg tggtggtaga catttctaat ctcagtacct gggaggccga
     8701 ggcaggcagc agtgggttcc aggtgacata acgggaccct gtataaacaa aataatttta
     8761 aaggaagtaa tgcagagatg ttaaaggggc cataaaagcc catagtctag agaaatgaca
     8821 caggctgaaa tactagcaga gtagcaaatg gaaggcagca ggtgagagct agggaagagg
     8881 ccagttgaca ccagttgata ccagtggggg ggggggcagc taaacaatgg gaactttaca
     8941 gtgataggtg ggaggtctga acttcccacc tgcttcatag aattacaaag tttttgtggt
     9001 aaataagacc tatggttgta accattttct taaaatcttt aaaaaaaata aatgtatgtg
     9061 tggatattgt gcactcaagt gcagatgccc agggtcagag gtaaagggtc ctggagttgt
     9121 gagatacagg cagttgtgag ctactctgta gtggtcctgg gaaccaaact tatgtcctcc
     9181 aagatttaca gcagcaagta ttcctaacca ctgagccatc tttcagccct tcttgttttt
     9241 taaaaaaaaa aaaaaaagtc tggttgtagg cacctttcac tgctgagctc tctctggccc
     9301 tgtccttaat ttttgacata gggtctctga ctgaaactgg agctcactga tcttagtgtc
     9361 tctatctccc tggcacttag attccgtgtg agtcactgca cctgacattg tgtgggtgct
     9421 agggatccaa actctggtcc taatgattgt gtggcaaaca ctttcccagc tgagccagct
     9481 tccaaatctg tgaaatgtaa cttttgacaa cgtggttatt gttagcgtgt catttacatt
     9541 ttggaggttt taaaataaat ttttgcacac ttttcatttt caagcaaaat aaaatagtga
     9601 aatgta
//
LOCUS       NM_001134523            2422 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus pleckstrin homology domain containing N1
            (Plekhn1), transcript variant 2, mRNA.
ACCESSION   NM_001134523 XM_001078287 XM_238442
VERSION     NM_001134523.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Kuriyama,S., Tsuji,T., Sakuma,T., Yamamoto,T. and Tanaka,M.
  TITLE     PLEKHN1 promotes apoptosis by enhancing Bax-Bak
            hetro-oligomerization through interaction with Bid in human colon
            cancer
  JOURNAL   Cell Death Discov 4, 11 (2018)
   PUBMED   29531808
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Maeda,A., Uchida,M., Nishikawa,S., Nishino,T. and Konishi,H.
  TITLE     Role of N-myristoylation in stability and subcellular localization
            of the CLPABP protein
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1249-1256 (2018)
   PUBMED   29180010
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Nishino,T., Matsunaga,R., Jikihara,H., Uchida,M., Maeda,A., Qi,G.,
            Abe,T., Kiyonari,H., Tashiro,S., Inagaki-Ohara,K., Shimamoto,F. and
            Konishi,H.
  TITLE     Antagonizing effect of CLPABP on the function of HuR as a regulator
            of ARE-containing leptin mRNA stability and the effect of its
            depletion on obesity in old male mouse
  JOURNAL   Biochim Biophys Acta 1861 (11), 1816-1827 (2016)
   PUBMED   27616329
REFERENCE   4  (bases 1 to 2422)
  AUTHORS   Sano,E., Shono,S., Tashiro,K., Konishi,H., Yamauchi,E. and
            Taniguchi,H.
  TITLE     Novel tyrosine phosphorylated and cardiolipin-binding protein
            CLPABP functions as mitochondrial RNA granule
  JOURNAL   Biochim Biophys Acta 1783 (6), 1036-1047 (2008)
   PUBMED   18191643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001134523.1.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000005.1  172094731-172094855 c
            126-225             JAXUCZ010000005.1  172094539-172094638 c
            226-372             JAXUCZ010000005.1  172091810-172091956 c
            373-453             JAXUCZ010000005.1  172091631-172091711 c
            454-526             JAXUCZ010000005.1  172091478-172091550 c
            527-651             JAXUCZ010000005.1  172091200-172091324 c
            652-765             JAXUCZ010000005.1  172091015-172091128 c
            766-846             JAXUCZ010000005.1  172090828-172090908 c
            847-922             JAXUCZ010000005.1  172090143-172090218 c
            923-1071            JAXUCZ010000005.1  172089852-172090000 c
            1072-1212           JAXUCZ010000005.1  172089578-172089718 c
            1213-1359           JAXUCZ010000005.1  172089217-172089363 c
            1360-1500           JAXUCZ010000005.1  172088916-172089056 c
            1501-1728           JAXUCZ010000005.1  172088527-172088754 c
            1729-2422           JAXUCZ010000005.1  172087524-172088217 c
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2422
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="pleckstrin homology domain containing N1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
     exon            1..125
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="upstream in-frame stop codon"
     CDS             43..1890
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pleckstrin homology domain containing, family N member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family N
                     member 1 isoform 2"
                     /protein_id="NP_001127995.1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
                     /translation="MGNSHCVPQTPRRLRASFSRKPSLKGNREDSARKLAGLFGTEAR
                     PDGDTAANKIFHYIPGTDILGPENHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKV
                     QLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELSICPIDGSREHAFQI
                     TGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLRQCHSAPPQGSLGDKLPWTQLWRA
                     HGCEPMNSAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLNFKGELPLSAI
                     HINLEEKEKEIRSFLIEGRLINTIRVVCASYEDYSQWLLCLRTVSHRDGAHLLPGPES
                     FPGLQRPTQVLGRGRGSLSSNGRTSRKLECPVFPTSQSLPEPSVPTTIGVPAHPVPNQ
                     TNSNCVSTGQTKVELRHSGSSQFPRGKAQREVSGSTAPLPLHLDLTKMSVLNLDSGPE
                     AQDCSPDIPHSPLYADPYTPPAIAHHKITDIQGLDEFLCAVQTSPGPELSSPFPSVSV
                     SVPVSDSNSGISSSPRPLGSHLLSKKGALQSRASQRHRGSIKSRAPQPSDFPQLGKGS
                     YFLNLMPESSLTPLLDEEAPIWNKTSSPSHQKWSHPRKPAVEGGFIQWI"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     exon            126..225
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            226..372
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            373..453
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            454..526
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            527..651
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            652..765
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            766..846
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            847..922
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1071
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1212
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1359
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1500
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1728
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..2422
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgtcg acctgccctg cccaagctag cagctgccat ccatggggaa cagccactgc
       61 gtccctcaga cccccaggag gctacgggcc tccttttcca gaaaaccctc gctcaaggga
      121 aacagagaag acagcgccag gaagctggct ggcctgtttg gcaccgaggc taggcctgat
      181 ggggacaccg cagctaacaa gatcttccac tacatccctg ggacggacat cctgggccca
      241 gaaaatcatc cagaaaacct ggaacagcca ttcctgagtg tattcaaaaa agggtggcgg
      301 aggacacctg tgaggaacct aggcaaggtg gtgcactatt ccaaggttca gctgcggttc
      361 cagcacagcc aggacatcag tgactgctat ctggaactgt tcccctccca cctgtacttc
      421 caggcccatg gttctgaagg acttacattc caggggctgc taccactgac ggaattgagc
      481 atctgcccga ttgatgggtc cagagagcat gccttccaga ttacaggccc actgcctgcc
      541 ccactccttg ttctctgcca cagtgaggcc gagctcagcc attggctcta ccacctggaa
      601 aagcaaatgg ctctcctggg tctgcggcaa tgccactcag cacccccaca gggttctcta
      661 ggagataaac tcccctggac ccagctatgg cgagcgcacg ggtgtgaacc catgaacagc
      721 gcaatctgtg cctcaagggt caagctgcag catctgccct cccaggagca gtgggaccgg
      781 cttctggtac tgtacccagc atccctggcc atcttctctg aggagccaga aggccttaac
      841 tttaaggggg agcttccact aagtgccatc catatcaact tagaagagaa ggaaaaagag
      901 atccgctcct ttctcatcga aggccgtctc atcaacacca tccgagtggt gtgtgccagt
      961 tatgaggatt acagtcaatg gctgctgtgc ctcaggacgg tctctcacag ggatggggcc
     1021 cacctgctgc ctggcccaga gagtttccca ggactacaga gacccacaca ggttttaggt
     1081 agaggccgag gttcactctc ttccaatgga cgaaccagcc ggaaattaga gtgtccagtg
     1141 ttccctacca gccaatccct ccctgagccc tcagtgccaa ccaccatagg tgtccctgcc
     1201 catcctgtgc ctaaccagac caactctaac tgtgtcagca ctggccaaac gaaggtagag
     1261 ctgaggcaca gtggcagtag ccagttcccc aggggcaaag ctcaaagaga agtatctggc
     1321 tcaactgccc cactgcccct gcacctggac ctgacgaaga tgagtgtcct gaacctagat
     1381 agtggcccag aggctcagga ttgctctcca gacattccac actccccgct ctatgctgat
     1441 ccctacacac caccagctat agctcaccac aagattacag acatccaagg cctggatgag
     1501 ttcctctgtg cagtacagac atcacctgga cctgaactat caagcccgtt cccctcagtc
     1561 tctgtgtctg tgcctgtctc tgactccaac tctggaatct ccagctcccc ccggcctctg
     1621 ggctcacact tgctctccaa gaaaggagcc ctgcagtcca gagcttccca gagacaccgg
     1681 ggttccatca agagcagggc cccacagccc tcagacttcc ctcagcttgg aaaggggtcc
     1741 tacttcttaa acctgatgcc tgagtcgtct ctgactcccc tactagatga agaggctcct
     1801 atctggaaca agacttcctc tccctcccac cagaagtggt cacatcccag gaagcctgcg
     1861 gtggaagggg gattcatcca gtggatctga tggcccccga gtgagctgct gcttctcaaa
     1921 aaacacaaac agccagcacc aaccgggata agagtatgca gttcggccag tcctttgact
     1981 tatattaaat acaccagggc ctaaccccat caggtcgagg gtgtttctag aattttgagg
     2041 atagaggcac ctctcaccag gctctagcta ctcagcttta gcagttggaa caaatgaaag
     2101 gaggtaaccc taggaacgaa ccagtgaggg acatcagtaa gattctgtac aaccccagaa
     2161 gctatacctc tagggggaga ggtgggggtg ctagtgcagg tctttactta gaagtgggga
     2221 acagcatgcg tgtgaaatac agagcactga aaaagtcagg ttgtcaaacc cagcctgtga
     2281 agccagaagg catgagggtc agagatcatt agggtgagag ctattacaag aagcaaagga
     2341 gtataggaaa agctagtact gttgggtgca cagggtaagg ttggtcagaa aaatgaacac
     2401 cataaacaag aaagagattt ta
//
LOCUS       NM_001105911            2739 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 29 member 4 (Slc29a4),
            mRNA.
ACCESSION   NM_001105911 XM_001072979 XM_039089185 XM_221940
VERSION     NM_001105911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Usui,T., Nakazawa,A., Okura,T., Deguchi,Y., Akanuma,S.I., Kubo,Y.
            and Hosoya,K.I.
  TITLE     Histamine elimination from the cerebrospinal fluid across the
            blood-cerebrospinal fluid barrier: involvement of plasma membrane
            monoamine transporter (PMAT/SLC29A4)
  JOURNAL   J Neurochem 139 (3), 408-418 (2016)
   PUBMED   27501284
  REMARK    GeneRIF: These results suggest the elimination of histamine from
            the CSF via plasma membrane monoamine transporter at the
            blood-brain barrier and blood-CSF barrier
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Wu,K.C., Lu,Y.H., Peng,Y.H., Hsu,L.C. and Lin,C.J.
  TITLE     Effects of lipopolysaccharide on the expression of plasma membrane
            monoamine transporter (PMAT) at the blood-brain barrier and its
            implications to the transport of neurotoxins
  JOURNAL   J Neurochem 135 (6), 1178-1188 (2015)
   PUBMED   26376205
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Gong,L., Goswami,S., Giacomini,K.M., Altman,R.B. and Klein,T.E.
  TITLE     Metformin pathways: pharmacokinetics and pharmacodynamics
  JOURNAL   Pharmacogenet Genomics 22 (11), 820-827 (2012)
   PUBMED   22722338
  REMARK    Review article
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Okura,T., Kato,S., Takano,Y., Sato,T., Yamashita,A., Morimoto,R.,
            Ohtsuki,S., Terasaki,T. and Deguchi,Y.
  TITLE     Functional characterization of rat plasma membrane monoamine
            transporter in the blood-brain and blood-cerebrospinal fluid
            barriers
  JOURNAL   J Pharm Sci 100 (9), 3924-3938 (2011)
   PUBMED   21538354
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Duan,H. and Wang,J.
  TITLE     Selective transport of monoamine neurotransmitters by human plasma
            membrane monoamine transporter and organic cation transporter 3
  JOURNAL   J Pharmacol Exp Ther 335 (3), 743-753 (2010)
   PUBMED   20858707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 13, 2025 this sequence version replaced
            XM_039089185.2, NM_001105911.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.49693.1,
                                           SRR26643298.79705.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000012.1  16988139-16988321   c
            184-357             JAXUCZ010000012.1  16984669-16984842   c
            358-489             JAXUCZ010000012.1  16977307-16977438   c
            490-603             JAXUCZ010000012.1  16976385-16976498   c
            604-732             JAXUCZ010000012.1  16975635-16975763   c
            733-807             JAXUCZ010000012.1  16974793-16974867   c
            808-1052            JAXUCZ010000012.1  16971510-16971754   c
            1053-1194           JAXUCZ010000012.1  16970734-16970875   c
            1195-1382           JAXUCZ010000012.1  16970438-16970625   c
            1383-1623           JAXUCZ010000012.1  16969424-16969664   c
            1624-2739           JAXUCZ010000012.1  16967047-16968162   c
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2739
                     /gene="Slc29a4"
                     /note="solute carrier family 29 member 4"
                     /db_xref="GeneID:288499"
                     /db_xref="RGD:1310545"
     exon            1..183
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            184..357
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Slc29a4"
                     /note="upstream in-frame stop codon"
     CDS             195..1766
                     /gene="Slc29a4"
                     /note="solute carrier family 29 (nucleoside transporters),
                     member 4; solute carrier family 29 (equilibrative
                     nucleoside transporter), member 4"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 4"
                     /protein_id="NP_001099381.2"
                     /db_xref="GeneID:288499"
                     /db_xref="RGD:1310545"
                     /translation="MGSIGSQRLKEPCVAATSGQSVVTSFDNFQLETTIEGAQDPGIR
                     VRGVPPFTDSAVDEPVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSI
                     VFDMSLTYILVALAAVLLNNVVVERLNLHTRITTGYLLALGPLLFISIFDVWLQLFSH
                     DQAYAINLAAVGTVAFGCTVQQSSFYGYTGLLPKRYTQGVMTGESTAGVMISLSRILT
                     KLLLPDERASTIIFFLVSAGLELLCFLLHLLVRRSRFVLYYTTRPRDSRPVRAGYRVH
                     HDVASGDIHFEHQTPALSSSRSPKDSPAHEVTHSNSGVYMRFDVPRPRVKRSWPTFRA
                     LLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCVLGEWLPILVMAVFNLSD
                     FVGKILAALPVDWRGTHLLACSCLRVVFIPLFILCVYPTGMPALRHPAWPCVFSLLMG
                     ISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHSS
                     CFQTATANDSILVGP"
     misc_feature    411..1682
                     /gene="Slc29a4"
                     /note="Nucleoside transporter; Region: Nucleoside_tran;
                     cl15430"
                     /db_xref="CDD:472807"
     misc_feature    411..1682
                     /gene="Slc29a4"
                     /note="Nucleoside transporter; Region: Nucleoside_tran;
                     cl15430"
                     /db_xref="CDD:472807"
     exon            358..489
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..603
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            604..732
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            733..807
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1052
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1194
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1382
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1623
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..2739
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctagctc gccgcagctg ctgcgcccct cgcacgcgct cgcggacccg ggcccgcgga
       61 ccgggacacc aaggaggacg cccgccgcgc ccggcccaag cctcgaagaa cggggcacag
      121 cgcaaagggt ccgggcgcgg gcggcgggca gccaccgagg atcccagcct ggggccggcc
      181 gagtgtgaac tgccatgggc tccattggaa gccagcgcct caaggagccc tgtgtggcag
      241 ccacatctgg ccagagtgtg gtgacaagct ttgacaactt tcagctggag acgacaatcg
      301 agggggctca ggatccaggc atcagagtca ggggcgtccc ccctttcaca gactctgcgg
      361 tagacgagcc tgtgccggac gaccgctacc atgccatcta ctttgccatg ctgctggctg
      421 gcgtgggctt cctactgccc tacaacagtt ttatcaccga tgtggactat cttcaccaca
      481 agtacccagg aacctccatc gtgtttgaca tgagcctcac ctatatcttg gtggcactgg
      541 cagccgtgct cctcaacaac gttgtggtgg agaggttgaa cctgcacact aggatcacca
      601 caggttacct cctggccttg ggtcccttgc tctttatcag catctttgat gtgtggcttc
      661 agctcttctc tcacgaccag gcttacgcca tcaacctggc cgccgtgggc actgtggcct
      721 ttggctgcac agtgcagcaa tctagcttct acggctacac aggattactg cccaagaggt
      781 acacgcaggg ggtgatgact ggagagagca cggcaggggt gatgatctct ctgagccgaa
      841 tcctcactaa gctgctgctc ccggatgagc gggccagcac catcatcttc ttcctggtct
      901 ctgctggctt ggagctcctg tgcttcctgc tgcacttgct ggtgcgacgc agccgttttg
      961 tgctctacta caccactcgg cctcgtgaca gccgccctgt ccgggcaggc taccgagtgc
     1021 accatgatgt cgcgtcagga gacatccact ttgagcacca aactccagcc ctgtccagca
     1081 gcaggtcccc aaaggacagc ccagcccatg aggtgaccca cagcaacagc ggcgtctaca
     1141 tgcgttttga tgtgccccgg ccacgagtca aacggagctg gcccaccttc agagccctgc
     1201 tgctgcaccg atacgtcgtg gcgcgggtca tctgggccga catgctatcc attgcggtaa
     1261 cttacttcat tacgctctgc ctgtttcctg gcctggagtc cgagatccgc cactgcgtgc
     1321 tgggcgagtg gctgcccatc ctggtcatgg ccgtgttcaa cctgtcagac tttgtgggca
     1381 agatcctggc agccctaccc gtggactgga ggggtaccca tctgcttgcc tgctcttgcc
     1441 ttcgtgtggt cttcatcccc ctcttcatcc tgtgtgtgta ccccactggt atgcctgccc
     1501 tccgtcaccc tgcctggccc tgtgtcttct cactgctaat gggcatcagc aatggctact
     1561 ttggcagcgt gcccatgatc ctggcagctg gaaaagtgag ccccaagcag cgggagctgg
     1621 cagggaacac catgactgtg tcctatatgt cggggttgac cctgggctct gctgtggcct
     1681 attgcaccta cagcctcacc cgtgacgccc acagcagctg ctttcaaaca gccaccgcca
     1741 acgactccat ccttgttggc ccctgagcca ggcccacccg atcctgccac ctgcccagga
     1801 agggctgctc gggccagata ccccaaggcc tgaggaccct cccacccctg cctcagtgcc
     1861 tgcggggtcc tggccgcctc ctaagccact aacgccacct tgctaccttg ttccagtcgc
     1921 acactgcagt tggagcatca ccacccaggg caccacctcc tcgtgtctgg gttgggtcgg
     1981 acacctgccc ttcaccctct atgtccagag gctccacgtt tgtcaccatg gtggggttat
     2041 tcagccactc ggaatggctg accacaatct gagttgactt ccttcactgt gaccccactg
     2101 tgcggtccca tgacggtctt caatgtagtt ttcatttact ggacgggggg gggggcacct
     2161 cctcatgagt atgagagatc ttggaggcaa gtccccaacc ccgttctgtc cccttcttgt
     2221 tcttacacac ttcttcacaa ccctccccga gctcccacat acataaagga ttaagactca
     2281 ttcctacgtc tacacaggcc tcctgtagtc atagcaacag agctgacctg ggtgcaccca
     2341 ccttaggtgg aggaccccca agccctcaga gcacaggcta agggccacac ccaacagatg
     2401 tcccatttcc tccccggctc cattcaattt atccataatg cagggacagc tgagatccac
     2461 tgtgacctac gtcgccccac tcccatccac tgagagtcaa gcagtgacac atcacacctg
     2521 aacccctggc aagtagcggg caaggtgagg agtggagtcc tgggagccag gactggctgt
     2581 aggacctcct gccagagaga gctttggctg aaccacgaca cttgcctctc cacacatctg
     2641 gccccagctg tgaccacctt gtaccaatcc ctgctgtgtc ctgtctacct gtgtgttctc
     2701 tgactaccgc actggccatt aaagatggca gagactgcc
//
LOCUS       NM_001436635            5087 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus MYB proto-oncogene like 1 (Mybl1), transcript
            variant 1, mRNA.
ACCESSION   NM_001436635 XM_006237749
VERSION     NM_001436635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5087)
  AUTHORS   Zhang,D., Xie,D., Lin,X., Ma,L., Chen,J., Zhang,D., Wang,Y.,
            Duo,S., Feng,Y., Zheng,C., Jiang,B., Ning,Y. and Han,C.
  TITLE     The transcription factor SOX30 is a key regulator of mouse
            spermiogenesis
  JOURNAL   Development 145 (11) (2018)
   PUBMED   29848638
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5087)
  AUTHORS   Li,X.Z., Roy,C.K., Dong,X., Bolcun-Filas,E., Wang,J., Han,B.W.,
            Xu,J., Moore,M.J., Schimenti,J.C., Weng,Z. and Zamore,P.D.
  TITLE     An ancient transcription factor initiates the burst of piRNA
            production during early meiosis in mouse testes
  JOURNAL   Mol Cell 50 (1), 67-81 (2013)
   PUBMED   23523368
REFERENCE   3  (bases 1 to 5087)
  AUTHORS   Bolcun-Filas,E., Bannister,L.A., Barash,A., Schimenti,K.J.,
            Hartford,S.A., Eppig,J.J., Handel,M.A., Shen,L. and Schimenti,J.C.
  TITLE     A-MYB (MYBL1) transcription factor is a master regulator of male
            meiosis
  JOURNAL   Development 138 (15), 3319-3330 (2011)
   PUBMED   21750041
REFERENCE   4  (bases 1 to 5087)
  AUTHORS   Ma,X.P. and Calabretta,B.
  TITLE     DNA binding and transactivation activity of A-myb, a c-myb-related
            gene
  JOURNAL   Cancer Res 54 (24), 6512-6516 (1994)
   PUBMED   7987850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237749.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1781605.1,
                                           SRR21887620.567824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000005.1  14365754-14366144
            392-497             JAXUCZ010000005.1  14374290-14374395
            498-569             JAXUCZ010000005.1  14374701-14374772
            570-662             JAXUCZ010000005.1  14377334-14377426
            663-883             JAXUCZ010000005.1  14379756-14379976
            884-1058            JAXUCZ010000005.1  14381472-14381646
            1059-1130           JAXUCZ010000005.1  14384029-14384100
            1131-1235           JAXUCZ010000005.1  14385306-14385410
            1236-1469           JAXUCZ010000005.1  14388742-14388975
            1470-1838           JAXUCZ010000005.1  14390071-14390439
            1839-1981           JAXUCZ010000005.1  14393986-14394128
            1982-2096           JAXUCZ010000005.1  14394526-14394640
            2097-2213           JAXUCZ010000005.1  14395703-14395819
            2214-2318           JAXUCZ010000005.1  14396044-14396148
            2319-2498           JAXUCZ010000005.1  14396575-14396754
            2499-5087           JAXUCZ010000005.1  14398424-14401012
FEATURES             Location/Qualifiers
     source          1..5087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..5087
                     /gene="Mybl1"
                     /note="MYB proto-oncogene like 1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
     exon            1..391
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    366..368
                     /gene="Mybl1"
                     /note="upstream in-frame stop codon"
     CDS             372..2627
                     /gene="Mybl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myb-related protein A; myeloblastosis oncogene-like 1"
                     /codon_start=1
                     /product="myb-related protein A isoform 1"
                     /protein_id="NP_001423564.1"
                     /db_xref="GeneID:297783"
                     /db_xref="RGD:1306940"
                     /translation="MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDD
                     KLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV
                     QKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNR
                     WAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHL
                     QTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMS
                     AENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQN
                     SPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDLSDAAASPVKSTPV
                     KLMRIQHNEGAMECQFNVSLVLEGKKNSCNGGDSEAIPLASPNVVKFSTPPTILRKKK
                     RLRVGQSAGSELGEGSLSEGNNAALKHTPVKTLPFSPSQFFNTCPGSEQLNIENPSFT
                     STPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQE
                     KKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRK
                     SLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINS
                     ANKTYTLTKKRPNPNTCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYT
                     APSSTSRALIL"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    483..665
                     /gene="Mybl1"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-bind_6; pfam13921"
                     /db_xref="CDD:372817"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    order(483..485,573..578,582..587,591..599,603..611)
                     /gene="Mybl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    621..>947
                     /gene="Mybl1"
                     /note="hypothetical protein; Provisional; Region:
                     PLN03091"
                     /db_xref="CDD:215570"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1089..1226
                     /gene="Mybl1"
                     /note="LMSTEN motif; Region: LMSTEN; pfam07988"
                     /db_xref="CDD:462332"
     misc_feature    1824..2294
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     misc_feature    1824..2294
                     /gene="Mybl1"
                     /note="C-myb, C-terminal; Region: Cmyb_C; pfam09316"
                     /db_xref="CDD:462753"
     exon            392..497
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..569
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..662
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..883
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1058
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1130
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1235
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1469
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1838
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1981
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2096
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2213
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2318
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2498
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..5087
                     /gene="Mybl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagctgc tcgctgcggg gagagggcgg gggtcggcgc ccgtgacgga gccgcgcagg
       61 gccggcagct ccaaggcgga ggcggaggcg gcgggagggg cgggcggagg gcgggagcac
      121 ggctcctgac atgtccaggg catccctggc cgggccgggc cgcggctagg agcagcgggt
      181 cttggtccgc ccctctgtcc ctcagtcccg cctggccctg acctgtcggg gcctgcgttc
      241 cgctctctcg gccacctgag ggaaggagcg gggtaagcgg cgggtgggtc tcggagaggg
      301 cgcactcgcc ccaggctgga ggaggctgac ccgcgtcccc gcccagcccg cgcctatgcg
      361 gtacttgaag gatggcgaag aggtcgcgca gtgaggatga ggacgatgac cttcagtatg
      421 ctgatcatga ttatgaagta cctcaacaaa aaggactgaa aaaactctgg aacagagtaa
      481 aatggaccag agatgaggat gacaagttaa agaagttggt tgaacaacac ggaactgatg
      541 attggactct aattgctagt catcttcaaa atcgttctga ttttcagtgc caacatcgat
      601 ggcagaaggt tttaaatcca gaattgataa agggtccttg gacgaaggaa gaagatcaga
      661 gggttattga attagttcag aaatatgggc caaaaaggtg gtctttaatt gcaaaacatt
      721 taaaaggaag aataggcaag cagtgcagag aaagatggca caatcacctg aaccccgagg
      781 taaagaagtc ttcttggaca gaggaagaag acaggatcat atacgaagcg cacaagcggc
      841 tgggaaaccg ttgggccgag attgcgaagt tacttcctgg aaggactgat aattctatca
      901 aaaatcattg gaattctacc atgagaagaa aagtggagca ggagggctac ttacaagacg
      961 gaataaaatc agagcggtct tcatccaaac ttcaacacaa accttgtgcg actatggacc
     1021 atttgcaaac ccagaatcag ttttacattc ctgttcagat ccctggttat cagtatgtgt
     1081 cacctgatgg caattgtgtt gaacatgtcc agacatctgc ctttattcag caaccctttg
     1141 ttgatgaaga tcctgataaa gagaaaaaaa taaaggagct cgagttgctt cttatgtcag
     1201 ctgagaatga agttagaaga aagaggcttc cacctcaacc tggaagcttt tctagctggt
     1261 ctggtagttt cctcatggat gatagtatgt ctaacacgct gaataatctt gaggagcaca
     1321 ctactgagtt ttatagcatg gatgaaaatc agactgtttc tgcccagcag aactcaccca
     1381 caaagtttct agctgtagaa gcaaatgctg tgctgtcctc tctacagacc atcccagaat
     1441 ttgcagaaac tctagaactt attgaatcgg atcctgtagc atggagtgat gttaccagtt
     1501 ttgatctttc tgatgctgct gcttctcctg tcaagtctac tccagttaaa ttaatgagaa
     1561 ttcagcataa tgaaggagcc atggaatgtc aatttaacgt cagtcttgtc cttgaaggga
     1621 aaaagaacag ttgtaatggt ggagacagtg aagctattcc tttagcatcc ccaaatgtgg
     1681 tcaagtttag cactccacca actatcctca gaaagaagaa aagactacga gtgggtcagt
     1741 ctgcaggcag tgagcttggt gaaggctcac tcagtgaggg caataacgca gccctgaagc
     1801 acacaccagt aaaaacacta ccgttttctc cttcacagtt ctttaacaca tgccctggaa
     1861 gtgaacaact taatatagaa aacccttcct ttacatcaac cccaatttgt ggacagaaag
     1921 ttcttattac aactcctctt caaaaggaag cgacccccaa agatcaaaaa gaaaatgtag
     1981 ggtttagaac acctactatt agaagatcga tactgggcac cacaccaaga actcctactc
     2041 cttttaagaa tgcacttgct gctcaggaaa agaaatatgg acctcttaaa attgtgtccc
     2101 agccacttgc cttcttggaa gaagacattc gagaggtttt aaaagaagaa actggaacag
     2161 atatattcct caaagaggaa gatgaacccg cttacaaaag ctgcaaacaa gagcactctg
     2221 catctgtgaa gaaagtcaga aagtcactgg ccttagagag ctgggacaaa gaagaaccgg
     2281 gcacccagct gctaactgaa gacatttcag acatgcagtc agaaaatatt cttacaacat
     2341 ctttattaat gataccatta ttggaaatac atgacaatag gtgcaacttg actcctgaaa
     2401 aacaagatat aaattcagcc aacaaaacat atacacttac taaaaagaga ccaaacccta
     2461 acacttgtaa agctgtcaaa ttggaaaaga gtcttcagtc aaattgtgaa tgggaaacag
     2521 tggtatacgg gaagacagaa gaccaactca tcatgactga acaagcaaga agatacctga
     2581 gcacttacac agctcccagc agcacatcga gagctctgat actctaactg ttactgaagc
     2641 tgatgaaagg ccccaccccc tactgtgctt atgctaaatt aggttgcaat gaaatttgtc
     2701 tcaattaatt cttttaaagg ttttaataca tccctaaaat ggttcgcggt tttttctata
     2761 ttgaacaggc aaaaacctaa taagccactt aacgtaaggg gtaggcaaat ttattataaa
     2821 tatattttta agaaatgaga gttttaaagc ttgtttttaa agaacaaagt gggaaaataa
     2881 ggatgttcat gggtattcca aagtcaattc tcacgttaat ttctttccag gatatatgtc
     2941 gctactttct caaggccgta gtctgttata aacaagttag gtgtgcgtgg cctctgaaag
     3001 tctgtgttta ggaagcacag aggctttatg aagtactttt gcatgtgtgc tgatttactt
     3061 agagaaacac agtgggaagg agcctcaagg aagctagaag ttgcactact aattttggta
     3121 tttttcagaa acaatgaaat taactacagt gttaaggata tttatttgtg catagtacta
     3181 aaaaagcatt gaaaaaaagg ctttttctta ctagtaaaga gtcagtattt cttcataagt
     3241 ctcagaagag ctgagaattt tgttgaatgt attgtacagt atgtaggagc aagaaaactt
     3301 tgtaaattgg aaagatgtct gtttttataa cttattttca tttttaaagc ttaaatgtag
     3361 atatttatat atacagggtg tctagaagcc agtgttgttt cttgccatta cagctaacat
     3421 agtaaagaat aactttgact ttcaagtatg aaatagttaa gttatagctt caaagaatac
     3481 aatatctata ctgtatgtca catctaccta aatattgcac tatatccttt aaatcatgtt
     3541 ggttataaag tagttctaaa atgtactaaa taataattta atattttctt tttaaattat
     3601 attggagggt catataaatt aatctggtga tttgtatatg tgtttgaaat tttcattttg
     3661 tttaaaaaac aatatggtac cttgctccct aaaacagtct gcacttagaa gtttattgta
     3721 tttactcaat gtttcagaag tagaaaatat tatcttttat ttatacaaat attttgtcct
     3781 tttataaatg ttttgtgttt ccaggttaca atagttgctt cagttgcctg tttaggtgtt
     3841 tgcacttact ttatctcttt ttgaaagaat gtctttgctt atgtggtaga gatttatgta
     3901 attttttgag acgtataatg gtgtgctgtc aacctaaaca ctgacaggca gatagaattg
     3961 tacactgtag tttgaattat ttataattga cacactctct ccctctccac tcctgaagta
     4021 tgctgctata gaaagtagca gagtcggctt gctgctatga gagatggaaa gagcaaccac
     4081 cacttgcact gtgtgaaaag ataagcaaat gatggccagt tctcaagtta actaatggat
     4141 tcaacgattc ccaagcaggt tcttaaaaga ccaaacacca ctgtgcctca aaaccaaacc
     4201 aaactgaaca gcttaagatt tttttaaaac tctacttatc tgttaataga aatgggacta
     4261 ctgaatattt taatgcctag ttcttcaaca gtagacctaa agggttttaa gctttaaatc
     4321 caattgctag tttttgcata ctatatgtta gtgagaagta aagaatatgt gtggtggtac
     4381 taagattatg cctcttgata acaaataggt aaaacaattt gaatcttctt agcatgttaa
     4441 atatgttgat ttttttctaa ttaatgaact tctcacagaa attttgcttt gtaaaaccaa
     4501 tgattgtgga aaaaaaatca tactctatca tttcagttac tttggggtaa taatagcaca
     4561 taattctttt ttttaaaaaa aaatgtagcc tttagctgca ttggatataa taatctccag
     4621 ttgccaaagt aaaatatctc agacacgcta catattttaa aacataattt ttcttgagca
     4681 ttaagttagc acaaatgtta atacattgtc cataagcctg ggcttatggg acataggaca
     4741 tatttgggtt ggtattggtt gaatcctcca gttaactgct ttgttgcttt ttgcaagatt
     4801 tgtaatcata aacatgttag gcatcttaag tcatcttttt ttactgttca cttatattct
     4861 tcagttttct gaagatgcca agcatacagg tagcagccat ccgtgcatgg aaactgactt
     4921 cacacatacc aatactgcat tctgttgtaa ggttttcaca ttaatacagc aattacactg
     4981 actaaattga gttttttaat atataaaaaa aaaactttgc attgtaagag aatcttgcag
     5041 acaatgttga aatctattaa catccaaata aaagcatctg tgtacaa
//
LOCUS       NM_001436643            4044 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus cartilage intermediate layer protein 2 (Cilp2),
            mRNA.
ACCESSION   NM_001436643 XM_006252902
VERSION     NM_001436643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4044)
  AUTHORS   Johnson,K., Farley,D., Hu,S.I. and Terkeltaub,R.
  TITLE     One of two chondrocyte-expressed isoforms of cartilage
            intermediate-layer protein functions as an insulin-like growth
            factor 1 antagonist
  JOURNAL   Arthritis Rheum 48 (5), 1302-1314 (2003)
   PUBMED   12746903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006252902.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000016.1  19574066-19574170
            106-204             JAXUCZ010000016.1  19574820-19574918
            205-477             JAXUCZ010000016.1  19575093-19575365
            478-633             JAXUCZ010000016.1  19575824-19575979
            634-912             JAXUCZ010000016.1  19576916-19577194
            913-1021            JAXUCZ010000016.1  19577382-19577490
            1022-1179           JAXUCZ010000016.1  19577992-19578149
            1180-4044           JAXUCZ010000016.1  19578236-19581100
FEATURES             Location/Qualifiers
     source          1..4044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4044
                     /gene="Cilp2"
                     /note="cartilage intermediate layer protein 2"
                     /db_xref="GeneID:306356"
                     /db_xref="RGD:1311157"
     exon            1..105
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..3530
                     /gene="Cilp2"
                     /codon_start=1
                     /product="cartilage intermediate layer protein 2
                     precursor"
                     /protein_id="NP_001423572.1"
                     /db_xref="GeneID:306356"
                     /db_xref="RGD:1311157"
                     /translation="MSSPLPLLYLCIAAAHLAGARDATPTEEHTATVRGLQGRPPDPG
                     QPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTD
                     WALPAAIGERVHANPERGFWCLNREQPRGRRCSNYHVRFRCPLEAAWGAWGAWGLCSK
                     SCGPGRRLRRRSCQSSSGDTCPGSPQEAQKCVRSRCPGCSSDTCGCPNHILLGSVVTP
                     SGRPLSGARVSLRTRPGTVATSDTHGTFRVPGVCAGSKANVSARMNGFSTGTAQAHAN
                     TSNSAVVTIVLEELGKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLL
                     DRRQQGSGPHLELQGLREEQAGEYHCKAWNEAGTVRSRAAHLTVLAPGQPACDPRPQE
                     HLIKLPDDCGQPGGGPTYLDVGLCADTRCPGPVGSGPRCGDAGSRCCSVLRLESRDIR
                     CSGYVLPVKVVAECGCRKCLPRRGLVRGRVVAADSGEPLRFARILLGLAPIGFTSYQG
                     DFTIEVPPATERLVVTFVDSSGEFVDSIRVLPFDPRGAGVYHEIRVLRKAAAVLLDAE
                     QGGEIPLGGTEEAPALGELVFPPRTFHHPDGRPYSGPVEARVTFVDPRDLASAAAASS
                     DLRYLDSSGELAPLRTYGMFAVDLHAPGSTEQLHVARADVRVDADHVRMPGHADALAL
                     WSLDPETGLWEEEGAEQGGGGFRREKEAVRVRREERTFLVGALTVRERRLFNLDVPER
                     RRCFVKVRAYGTDRFAPSEQVQGVVVTLLNLEPAPGFTANPRAWGRFDSAVTGPNGAC
                     VPAFCDAERPDAYTAFVTASLGGEELEAAPSRPRATAATVGVAEPYLERLGYQRTDHD
                     DPALKRTGFRLNLARPRTGHESEAHGPVYPWRRLRDCEDAPVTDSHFRFSRVEADKYE
                     YDVVPFHEGAPASWTGDLLAWWPNPQEFRACFLKVRLQGPQEYMVRSHNAGGTHEDTR
                     GHLYGLRDTRSVRNPERPGASAACVEFKCGGMLFDQRQVDRTLVTVTPQGSCRRVAVN
                     TLLQDYLARHPPLAPADDPATFAMLAPLDALGHNYGVYTVTDQSPRLAKEIAIGRCFD
                     GSSDGFSREMKADAGTAVTFQCREPPARPSLFQRLLENPASALGDIRREMGQAARDSR
                     VTQTQAGDTGPFGSGQ"
     sig_peptide     42..101
                     /gene="Cilp2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    216..470
                     /gene="Cilp2"
                     /note="Mucin-2 protein WxxW repeating region; Region:
                     Mucin2_WxxW; pfam13330"
                     /db_xref="CDD:463846"
     misc_feature    216..470
                     /gene="Cilp2"
                     /note="Mucin-2 protein WxxW repeating region; Region:
                     Mucin2_WxxW; pfam13330"
                     /db_xref="CDD:463846"
     misc_feature    513..632
                     /gene="Cilp2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    513..632
                     /gene="Cilp2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    678..902
                     /gene="Cilp2"
                     /note="Carboxypeptidase regulatory-like domain; Region:
                     CarboxypepD_reg; pfam13620"
                     /db_xref="CDD:433354"
     misc_feature    678..902
                     /gene="Cilp2"
                     /note="Carboxypeptidase regulatory-like domain; Region:
                     CarboxypepD_reg; pfam13620"
                     /db_xref="CDD:433354"
     misc_feature    915..1133
                     /gene="Cilp2"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    915..1133
                     /gene="Cilp2"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     exon            106..204
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..477
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..633
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..912
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1021
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1179
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..4044
                     /gene="Cilp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggatcc cagagtttcg cagagcagct cggacctggc gatgtcgtca cctctgccct
       61 tgctctatct ctgcatcgct gccgcacacc tagcgggagc gcgagatgcc acccccaccg
      121 aggagcacac tgcaaccgtc aggggtcttc agggacggcc accagacccc ggccagccct
      181 cgccggccct ggaggactgg gaggaggcca gcgagtggac ctcgtggttc aacgtggacc
      241 acccgggagg agatggtgac ttcgagagcc tggcagccat tcgcttctac tatggtcccg
      301 cgcgcgtgtg cccgaggccg ctggcactgg aggcgcgcac cacggactgg gcactacccg
      361 ctgcaatagg cgagagggtg cacgccaacc cagagcgcgg attctggtgt cttaatcgcg
      421 agcagccgcg aggccgccgc tgctccaact accacgtgcg cttccgctgc ccactggagg
      481 cggcatgggg cgcttggggc gcttggggcc tctgttccaa gagttgcggg ccaggccgtc
      541 gcctgcgccg tcgcagctgt caaagctcat ctggggacac atgtcctggg agcccccagg
      601 aggcacagaa gtgcgtgaga tcccgttgcc caggatgtag ctctgacacc tgcgggtgcc
      661 ccaaccacat cctcttgggc tcggtggtca ccccatctgg gcgaccgctg tcaggagcca
      721 gggtctccct gcgaacacga cctggcaccg tagccaccag tgacacccat ggaaccttcc
      781 gggtgcctgg agtctgcgct ggcagcaagg ccaacgtcag tgcccggatg aatggcttct
      841 ctactggtac agcccaggcc catgccaaca cctccaactc tgctgtggtc accatcgtcc
      901 ttgaagagtt agggaagccg tacctggtaa agcaccctga gtctcgagtt cgagaggcag
      961 gtcagaatgt gaccttctgc tgcaaggcct ctgggacacc catgcccaag aaatattcct
     1021 ggttccacaa cgggacctta ctggaccgac gccagcaggg gtctgggcca cacctagagc
     1081 tccaggggct tcgtgaggag caggcagggg agtaccactg caaagcctgg aacgaggcgg
     1141 gcaccgtgcg atcccgcgct gcccacctca cggtgctcgc tcccggccag ccagcctgtg
     1201 acccccgacc tcaggaacac ctgatcaagc ttccggatga ctgcggccag ccgggtggcg
     1261 gccccacgta cctagacgtg ggactgtgcg cagacacgcg ctgcccgggc cccgtgggct
     1321 ccggcccgcg ctgtggggac gcgggctctc gctgctgctc agtgctgcgc ctggagagca
     1381 gagatatccg ctgctctggc tatgtgctcc cagtgaaggt ggtggctgag tgtggctgtc
     1441 gcaagtgcct gccccgtagg ggattggtgc gaggccgcgt ggtggctgcg gactctgggg
     1501 agcccctgcg tttcgccagg attctattgg gccttgcacc catcggcttc acctcctacc
     1561 agggcgactt caccatcgag gtgccgccgg ccaccgagcg cctcgtggtg accttcgtgg
     1621 actcgagtgg tgagttcgtg gacagcatcc gcgtgttgcc tttcgaccct cgcggcgctg
     1681 gtgtgtacca cgagatccgc gtgctgcgca aggcggccgc agtgctgctg gacgcggagc
     1741 agggcggtga aattccgctg ggcggcacag aggaggcgcc agcgctaggc gagctagtct
     1801 tcccgccccg gaccttccac caccccgacg gccgtcccta ctcggggccc gtggaggcgc
     1861 gtgtcacctt cgtggaccct cgtgacctgg cgtcggcggc cgcggcgtcc agcgacctgc
     1921 gctacctgga tagctcgggt gagctggcgc cgctgcgcac ctatggcatg tttgcagtgg
     1981 acctgcacgc gccaggctcc accgagcagc tgcacgtggc gcgcgcggac gtgcgcgtgg
     2041 acgccgacca cgtgcgcatg cccggacacg ccgatgctct ggcactctgg tcgttggacc
     2101 cagagaccgg cctgtgggag gaggaggggg ctgagcaggg aggaggcggc ttccggcgtg
     2161 agaaggaggc ggtgcgcgtg cgcagggagg agcgcacgtt cctcgtgggc gcgctcacgg
     2221 tgcgcgagcg ccgcttattc aacctagacg tgcccgagcg gcgccgctgc ttcgtgaagg
     2281 ttcgcgccta cggtacagat cgcttcgcgc cctcagagca ggtgcagggc gtggtggtga
     2341 cgctgctcaa tctggaaccc gcgcccggtt tcacggccaa cccacgcgcg tggggccgct
     2401 tcgacagcgc ggtcacaggg cccaacggcg cgtgcgtgcc ggccttctgc gacgccgagc
     2461 ggcccgacgc ctacacggcc ttcgtgaccg cgtctctagg aggcgaggag ctggaggccg
     2521 cgccgtcgcg gccacgcgcg accgcggcca ccgtgggcgt ggcagagccc tacctggagc
     2581 gcctcggcta ccagcgcacc gatcacgacg accccgcgct caagcgcacc ggcttccgct
     2641 tgaaccttgc acgtccacgc acgggccacg agtccgaggc gcacgggccc gtgtatccgt
     2701 ggcgccgcct gcgcgactgc gaggacgcgc cggtcaccga cagtcacttc cgattctcgc
     2761 gcgtagaggc agacaagtac gagtacgacg tggtgccatt ccacgaggga gcgcccgcct
     2821 cgtggacagg cgacctgctg gcctggtggc ccaacccgca ggagttccga gcgtgcttcc
     2881 tgaaggtgcg gctgcagggc ccccaggagt acatggtgcg ttcgcacaac gcgggcggca
     2941 cccacgaaga cacgcgcggc cacctctatg ggctgcgcga cactcgcagc gtgcgcaacc
     3001 ctgagcgccc gggcgcctcg gccgcctgcg tggagtttaa gtgcggtggc atgctgtttg
     3061 accagcgcca agtggacagg acactggtga ctgtgacccc gcagggcagc tgccgccgcg
     3121 tggccgtcaa cacgctcctg caggactatc tagcccggca cccgccgctc gcccccgcgg
     3181 acgaccccgc caccttcgcc atgctggctc cgcttgacgc cctgggccac aactatggtg
     3241 tctacaccgt caccgaccag agcccacggc tggccaagga aatcgccatc ggccgctgct
     3301 tcgacggctc ctcggacggc ttctcccggg agatgaaggc ggacgcgggc acagcggtta
     3361 ccttccagtg ccgagagccg cccgccagac ccagcctctt ccagaggctg ctggagaacc
     3421 ccgcatcggc gcttggcgac attcgtaggg agatgggcca agccgcccgc gattcccggg
     3481 ttacccaaac ccaggctggg gacaccggcc ccttcggttc tggacagtga cctggtccac
     3541 gacttcattc tgccttgctt tggactcgtg tatcttcgaa aaacctcccc gctttggctc
     3601 ccaggcttga gtcccctccc ccacttgtcc accaagaatt tgttcaagat gaaaactaag
     3661 ggtgctggtg ggaatttggg gcaggcagcc gtggctgtga ccagaaacag tgtccagttg
     3721 taggtgaacg tggttgtcca cctaaggcct gggcctcagc cgaggcaggt tctgagtgac
     3781 tccaatgccc tgggtcgtcg cagcctttgt gggctcccct gccccagctt tggttctgag
     3841 accgtattta ttgagataaa gcccaggggg tgggtttgag ttgggataca ggttggcccc
     3901 gtggaatgtg aggaaagggt gttttggggt tgccatgcag gaggagctag ggctccaggg
     3961 gggacggatc catggtgctt gggaatgccc tcaggacttg ggggcaggtg ctatcgggct
     4021 caattaaaaa tgctacaatt ccca
//
LOCUS       NM_001436604            5775 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus aprataxin (Aptx), transcript variant 1, mRNA.
ACCESSION   NM_001436604 XM_006238027
VERSION     NM_001436604.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5775)
  AUTHORS   Castellotti,B., Mariotti,C., Rimoldi,M., Fancellu,R., Plumari,M.,
            Caimi,S., Uziel,G., Nardocci,N., Moroni,I., Zorzi,G., Pareyson,D.,
            Di Bella,D., Di Donato,S., Taroni,F. and Gellera,C.
  TITLE     Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent
            aprataxin mutations, coenzyme Q10 analyses, and clinical findings
            in Italian patients
  JOURNAL   Neurogenetics 12 (3), 193-201 (2011)
   PUBMED   21465257
REFERENCE   2  (bases 1 to 5775)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   3  (bases 1 to 5775)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   4  (bases 1 to 5775)
  AUTHORS   Ferrarini,M., Squintani,G., Cavallaro,T., Ferrari,S., Rizzuto,N.
            and Fabrizi,G.M.
  TITLE     A novel mutation of aprataxin associated with ataxia ocular apraxia
            type 1: phenotypical and genotypical characterization
  JOURNAL   J Neurol Sci 260 (1-2), 219-224 (2007)
   PUBMED   17572444
REFERENCE   5  (bases 1 to 5775)
  AUTHORS   Takahashi,T., Tada,M., Igarashi,S., Koyama,A., Date,H.,
            Yokoseki,A., Shiga,A., Yoshida,Y., Tsuji,S., Nishizawa,M. and
            Onodera,O.
  TITLE     Aprataxin, causative gene product for EAOH/AOA1, repairs DNA
            single-strand breaks with damaged 3'-phosphate and
            3'-phosphoglycolate ends
  JOURNAL   Nucleic Acids Res 35 (11), 3797-3809 (2007)
   PUBMED   17519253
REFERENCE   6  (bases 1 to 5775)
  AUTHORS   Kijas,A.W., Harris,J.L., Harris,J.M. and Lavin,M.F.
  TITLE     Aprataxin forms a discrete branch in the HIT (histidine triad)
            superfamily of proteins with both DNA/RNA binding and nucleotide
            hydrolase activities
  JOURNAL   J Biol Chem 281 (20), 13939-13948 (2006)
   PUBMED   16547001
REFERENCE   7  (bases 1 to 5775)
  AUTHORS   Gueven,N., Becherel,O.J., Kijas,A.W., Chen,P., Howe,O.,
            Rudolph,J.H., Gatti,R., Date,H., Onodera,O., Taucher-Scholz,G. and
            Lavin,M.F.
  TITLE     Aprataxin, a novel protein that protects against genotoxic stress
  JOURNAL   Hum Mol Genet 13 (10), 1081-1093 (2004)
   PUBMED   15044383
REFERENCE   8  (bases 1 to 5775)
  AUTHORS   Sano,Y., Date,H., Igarashi,S., Onodera,O., Oyake,M., Takahashi,T.,
            Hayashi,S., Morimatsu,M., Takahashi,H., Makifuchi,T., Fukuhara,N.
            and Tsuji,S.
  TITLE     Aprataxin, the causative protein for EAOH is a nuclear protein with
            a potential role as a DNA repair protein
  JOURNAL   Ann Neurol 55 (2), 241-249 (2004)
   PUBMED   14755728
REFERENCE   9  (bases 1 to 5775)
  AUTHORS   Shimazaki,H., Takiyama,Y., Sakoe,K., Ikeguchi,K., Niijima,K.,
            Kaneko,J., Namekawa,M., Ogawa,T., Date,H., Tsuji,S., Nakano,I. and
            Nishizawa,M.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia:
            the aprataxin gene mutations
  JOURNAL   Neurology 59 (4), 590-595 (2002)
   PUBMED   12196655
REFERENCE   10 (bases 1 to 5775)
  AUTHORS   Moreira,M.C., Barbot,C., Tachi,N., Kozuka,N., Uchida,E., Gibson,T.,
            Mendonca,P., Costa,M., Barros,J., Yanagisawa,T., Watanabe,M.,
            Ikeda,Y., Aoki,M., Nagata,T., Coutinho,P., Sequeiros,J. and
            Koenig,M.
  TITLE     The gene mutated in ataxia-ocular apraxia 1 encodes the new
            HIT/Zn-finger protein aprataxin
  JOURNAL   Nat Genet 29 (2), 189-193 (2001)
   PUBMED   11586300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238027.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1721343.1,
                                           SRR21887623.365850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  60618653-60618840   c
            189-325             JAXUCZ010000005.1  60611539-60611675   c
            326-372             JAXUCZ010000005.1  60609743-60609789   c
            373-639             JAXUCZ010000005.1  60609265-60609531   c
            640-699             JAXUCZ010000005.1  60607510-60607569   c
            700-926             JAXUCZ010000005.1  60605329-60605555   c
            927-1030            JAXUCZ010000005.1  60599244-60599347   c
            1031-5775           JAXUCZ010000005.1  60593338-60598082   c
FEATURES             Location/Qualifiers
     source          1..5775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5775
                     /gene="Aptx"
                     /note="aprataxin"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
     exon            1..188
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    127..129
                     /gene="Aptx"
                     /note="upstream in-frame stop codon"
     exon            189..325
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1185
                     /gene="Aptx"
                     /EC_number="3.6.1.72"
                     /EC_number="3.6.1.71"
                     /note="isoform a is encoded by transcript variant 1;
                     FHA-HIT; forkhead-associated domain histidine triad-like
                     protein"
                     /codon_start=1
                     /product="aprataxin isoform a"
                     /protein_id="NP_001423533.1"
                     /db_xref="GeneID:259271"
                     /db_xref="RGD:628740"
                     /translation="MRVCWLVRQDCWHQRIKLPHLEAVVIGRSPETKITDKKCSRQQV
                     QLKAECNKRYVNVKQMGVNPTSIDEVVIGKDREMKLLPGQVLHMVNELYPYMVEFEEV
                     AESPNVTQRKRKRPDCDSQEMEAEAGASPSQCSVSPKTGKHGAAKEESLGHWSQGLKI
                     SMKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVG
                     EKVIADFTGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLE
                     SQAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG"
     misc_feature    196..480
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interactions with ADPRT/PARP1 and NCL.
                     /evidence=ECO:0000250"
     misc_feature    199..498
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    199..498
                     /gene="Aptx"
                     /note="forkhead associated (FHA) domain superfamily;
                     Region: FHA; cl00062"
                     /db_xref="CDD:469597"
     misc_feature    order(274..279,313..318,322..324,382..387)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    order(274..279,313..318,322..324,382..387)
                     /gene="Aptx"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438714"
     misc_feature    511..642
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    526..540
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    553..555
                     /gene="Aptx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQC5; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); phosphorylation site"
     misc_feature    646..951
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    646..951
                     /gene="Aptx"
                     /note="aprataxin related: Aprataxin, a HINT family
                     hydrolase is mutated in ataxia oculomotor apraxia
                     syndrome. All the members of this subgroup have the
                     conserved HxHxHxx (where x is a hydrophobic residue)
                     signature motif. Members of this subgroup are...; Region:
                     aprataxin_related; cd01278"
                     /db_xref="CDD:238609"
     misc_feature    676..678
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    733..747
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    907..909
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    919..924
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3"
     misc_feature    order(928..930,934..936,940..948)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    order(928..930,934..936,940..948)
                     /gene="Aptx"
                     /note="HIT family signature motif [active]"
                     /db_xref="CDD:238609"
     misc_feature    928..942
                     /gene="Aptx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4H4.1);
                     Region: Histidine triad motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00464"
     misc_feature    934..936
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    934..936
                     /gene="Aptx"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238609"
     misc_feature    940..942
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    985..987
                     /gene="Aptx"
                     /note="Interaction with DNA substrate.
                     /evidence=ECO:0000250|UniProtKB:Q7Z2E3; propagated from
                     UniProtKB/Swiss-Prot (Q8K4H4.1); other site"
     misc_feature    1003..1176
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     misc_feature    1003..1176
                     /gene="Aptx"
                     /note="C2HE / C2H2 / C2HC zinc-binding finger; Region:
                     zf-C2HE; pfam16278"
                     /db_xref="CDD:465082"
     exon            326..372
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            373..639
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            640..699
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            700..926
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1030
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..5775
                     /gene="Aptx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagcgt ggaggtttgt aagtgtgcag tcgaggtaag ctagtggtcg gcctgctttc
       61 gtagctggtt gggttagaag ccagcagggg cgtttggccg gggctgctaa cccggagcgg
      121 ataccttgaa ggtggagttc gaggtttcct tctgggtgga ccaagcccca ccctttcgtc
      181 ctgttcagag ccaagatgcg ggtgtgctgg ttggtgagac aggactgctg gcaccagcga
      241 atcaaacttc cccatttaga agctgttgtg attggtcgaa gcccggagac caagatcaca
      301 gataagaaat gttcccgaca gcaagtacag ttgaaagcgg agtgtaacaa gagatatgtc
      361 aacgttaagc agatgggggt caatcccacc agcattgacg aagtcgtcat tgggaaggac
      421 cgggagatga agctgctgcc tggtcaggtt ctccacatgg tgaatgaact ttatccatac
      481 atggtggagt ttgaggaggt ggcagagagc cctaacgtaa cacagaggaa gagaaagagg
      541 ccagactgtg atagtcagga gatggaagct gaggctgggg ccagccccag ccagtgctct
      601 gtgtccccta agacgggcaa gcatggagcc gccaaggagg aatcactggg ccactggagt
      661 caaggcttga agatatctat gaaagacccc aaaatgcagg tttataagga tgatcaggtg
      721 gtggtgatta aggataaata ccccaaggcc cggcaccact ggctggtctt accatgggcc
      781 tccatttcca gtctgaaggt tgtgaccagt gaacacctcg aacttctcaa acacatgcac
      841 gcagtagggg aaaaggtgat agcagatttt actggatcca gcaaactgcg cttccgactg
      901 ggttaccatg ccattcccag catgagccat gtacatcttc atgtgatcag ccaggatttt
      961 gattctcctt gccttaaaaa caaaaagcat tggaattctt tcaatacaga atattttctg
     1021 gagtcacaag ctgtgatcaa gatggttcag gaagctggca gagtgactgt taaagatggg
     1081 acttgcgaac tcttgaagct gcctctccgt tgccatgagt gtcagcagct gctgccttcc
     1141 atcccacagc tgaaggagca cctcaggaag cactggggcg ggtgacactc gccttggtga
     1201 ccgagtgcag tgctagcatc attctgcatt gcctgcgctc cgttcagtcc tgaactaaag
     1261 catgcagctc ttcaaaacaa agcttattat tcttgagtga ccacacaggg tgactctggg
     1321 tcaggaactg ggaatatggg tttgtatggt atattttctg gtaatggagg atgagacatg
     1381 cctgatcact cttcccaaga ccatgtcagg cctgactaat aagagggcag agccagcttg
     1441 aggttcaaat acaagatgta gaagcagagg actggtaatg tatttgttcc tacccttgcc
     1501 cctggatcat gttctatctt tttatcaaga tagctgaggt tctgaggggg cctggttcct
     1561 gctctatgat attcctcttc cctccatgag gaggctttca atctactgta ccaggctgag
     1621 tgcctgggtg aacatatgtg gcagtcatct gcacagagag atactttgtg tatgactgtg
     1681 ccagggaact ggaagtggta atattgggca cagtatgtta acagtacagc ctgtgtcgag
     1741 ggcaaactgg ggtaatgtga actgccagta aacagtacat cctctgctga gggcagcctg
     1801 gggcagtgtg aactgccagt aaacagtaca gcctgtgctg agggcagcat ggaacagtgt
     1861 gaactgttag tgaacagtag tctgttctga gggcagcctt gtacagtgat gtcagttaac
     1921 agtgcagtct gttgagggca tcctgggatg gtgtgaactg tcagttaaca gtgcagtctg
     1981 ttgagggcat cctgggatgg tgtgaactgt cagttaacag tgcagtctgt tgagggcatc
     2041 ctgggatggt gtgaactgtc agttaacagt gcagtctgtt gagggcatcc tgggatggtg
     2101 tgaactgtca gttaacagtg cagtctgttg agggcatcct gggatggtgt gaactgtcag
     2161 ttaacagtgc agtctgtgtt gagggcagcc tgggcagtgt gtattgttag cttcaggcag
     2221 attttacgga ggcttcagcc actgctcttg agaattacag aacatttaac taaacttcgg
     2281 ataatgtatc ttagaaaaac agatgttgca aaatagttca tttactttcc acctgataca
     2341 atatagttta gcacatcagt attaaaatga gtatttgctg taaactacta ggagtgtctg
     2401 tatcagacag cgtaagaatg tcaggtataa tgagaaacat ttggggaatg aggtgaccat
     2461 gcttacattc ttccttctgc ccaaaataga tttttttaag actggggtga gtgcatgctg
     2521 cccttcctag gacctgagtt ttgttcccgg catccatatt aggtggctca cagctgcctg
     2581 tagctccagg gatcctgcac ctgcttcttg acctctgtgg gcactgcatt caagtacaca
     2641 aacctgaata cagacacaca ttcacacata attaaatctg taaaaatcag atctcgggct
     2701 ggagagatgg ctcagtggtt aagagctcct ccagaggtcc tgagttcaat tcccagcaac
     2761 cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg tatgcatgga
     2821 gacagccaca gtgcacttat acataaataa atacataaat aaaaaaaata gatctcttag
     2881 aggaaaaatg tcaataatga ctggcaggaa gcaggtattg aggtattgag gtttattcat
     2941 tccctagccc tcctctccga aatgggcttt tatcaccatg gggaagaaga ctgtctggac
     3001 tctggattac ttgacagaca tgtcattgta caattagttg aagctttcct tcagagtcag
     3061 agggagggat gttgggagac tgcaaagtag aagaaagcca gccacattta aagctaggca
     3121 cagtggcaaa ttctcttgca atcccaaatt taggaggtgg tagatccagg agggccaggc
     3181 attccaggtt atccttgtct atatggtgaa cttgaggtct ggactacatg agaccctatg
     3241 tcacagaagc aaataaataa aagatttaaa aaggggaaat aaaattctat ctaaggtacc
     3301 aaagcatatt atttggccca tcatggccag gcaagaccag ttgttatcaa agcagctgtt
     3361 atggctggaa tctgggataa ctcaggctca tgttctggag cgtgggtcct ttccttgcag
     3421 tgttgtttag atgactgtga agccattagg gtgaagccgg gctggcagaa gtaggtgtct
     3481 aggagcaggc aggccctgaa ggctataccc tttcccggct cctggtgggc tgctttacct
     3541 cctgtgaaca ggacacccat ctctgctact atggactgac actgtgtgtg tgtgcgcgtg
     3601 cgcacacgcg cgcgcgtgtg tacacaagag gacaatttct ggaagtcaat tgtctccacc
     3661 atattggccc tagggattga ctcactagct tgactcagtg tctttaccca ctgagttcca
     3721 gtaagtcaga agtactcttt taagaaatag caacttaggg cctggagtga cggctcaggg
     3781 gttaagagca ctgactgctc ttccagaggt cctgagttca attcccagca accacatggt
     3841 ggctcacaac catctgtaac aggatccgat ttacatataa taaataaata aatcttaaaa
     3901 aaaagaaata acttaattct caagtacgta cacacacaca cacacacaca cacacacaca
     3961 cacacacaca cacactctct ctctctctct cctaccttat cccaagctac cctaaactca
     4021 ccatgtagac taggatgacc ttgaacttgc tgagatctgc cagtccagag ccagggtact
     4081 gggattcaag tatcccacca aagaggaaaa taagcaaatg tacaaggatt agatagacat
     4141 tgcccataat taattaaaat tcagtgtttt ctgagagtgg aaatattgtc atgaaatatt
     4201 cccttttgca gcaatgctca gatctgcctc tttagaatgg tctttctttt tgaatgttgc
     4261 taatggtgta ctggctggtt ttgtgtatca atttggcaca cgctagagtc atcagagagg
     4321 aaggaccttc agttgagaaa atgcctccat gagctccagc tgtaagacat tttcataatt
     4381 agggatcagt ggggctagcg ccattgtggg tggtaccact cctggactgg tggtcctggg
     4441 tcctataaga aggcaggctg agcaagccag gggaagcaag ccagtgtggg gtgggggcac
     4501 cccactcatg gtctctgcct cagctcctgt ctccaggttc ctgctctgtc tgagttcctg
     4561 tcctggctgc ctttggtggt gaacatgact gctgtgtgat tgcctgtctg tcactcgggc
     4621 tttatggtat cccagggcat tcagaattgg gaggtgcata atggagtgtt atttaagcca
     4681 taaataatga acagaatgga attgtgtcct ttgccagaag acagataccc tggaggtcat
     4741 cctgtgaaac gcaatcagcc agactcagaa cagtcacctc atactggtat ttcaaaggtc
     4801 ttggctctcc tgactctatg cccatcgtga ggcagagcat agcagaggtt gaagcatgta
     4861 caaagccttc ttggcacatg ggacaaagag gcagagacac cactttgttc tgagattggt
     4921 cttactgtgt agcaaagact gacctggaat tcatgcagct cagtttggtc ttgagttcaa
     4981 gacccaactg ccttagcagt tctgggtgtg tgctaggaag tgttctcaga taatgttttc
     5041 agagcacgag acaccttcat gtgtaggcta tcatgagtca actaaccttt ctgtggctgg
     5101 accctgcagg taaggggtgg agcgcagggc agaggagaga cttctggcac tctaaggagc
     5161 ctgtggacca cctagattct tacctgctgc taacatttcc acaccacagg caccctctag
     5221 cctatggcag ctgggaactt atttttgctt tcaagaaccc agtgataggt ctgtttctca
     5281 aatacagctg atgtggctga ccttgagtga aaggagactg aaggttttag gagaccccag
     5341 tatgtagacc tgactgaact tgcccctgaa gctgacagcc cattgcatac tcttcacatg
     5401 aatgagaaaa aggtgcctgt tgtatgtgga ggcctttaac ccagatcccc tgaggccgga
     5461 gcccatgtga ggcacaacta catgaccaca tagggtgatg tgatggtttg catatttggc
     5521 ccagggagtg gcactattag aaggtgtggc cttgttggag gaagtgtgtc actgtggggg
     5581 ggtgggcttg gagaccctcc tcctagctgc ctggggatgc tcagtctgtt cctggcttcc
     5641 tttggttgaa gatgtagaac tcagctcctc ctgcaccagg cctgcctgga tgctgccatg
     5701 ctcctgcctt gataatggac taaacctctg atctgtaagc cagccctaat taaatgttgt
     5761 cctttataaa actta
//
LOCUS       NM_001436644            1400 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus short chain dehydrogenase/reductase family 16C,
            member 5 (Sdr16c5), transcript variant 1, mRNA.
ACCESSION   NM_001436644 XM_006237836
VERSION     NM_001436644.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Takahashi,Y., Moiseyev,G., Farjo,K. and Ma,J.X.
  TITLE     Characterization of key residues and membrane association domains
            in retinol dehydrogenase 10
  JOURNAL   Biochem J 419 (1), 113-122 (2009)
   PUBMED   19102727
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Lee,S.A., Belyaeva,O.V. and Kedishvili,N.Y.
  TITLE     Biochemical characterization of human epidermal retinol
            dehydrogenase 2
  JOURNAL   Chem Biol Interact 178 (1-3), 182-187 (2009)
   PUBMED   18926804
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Markova,N.G., Pinkas-Sarafova,A. and Simon,M.
  TITLE     A metabolic enzyme of the short-chain dehydrogenase/reductase
            superfamily may moonlight in the nucleus as a repressor of promoter
            activity
  JOURNAL   J Invest Dermatol 126 (9), 2019-2031 (2006)
   PUBMED   16691198
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Matsuzaka,Y., Okamoto,K., Tsuji,H., Mabuchi,T., Ozawa,A., Tamiya,G.
            and Inoko,H.
  TITLE     Identification of the hRDH-E2 gene, a novel member of the SDR
            family, and its increased expression in psoriatic lesion
  JOURNAL   Biochem Biophys Res Commun 297 (5), 1171-1180 (2002)
   PUBMED   12372410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237836.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20512.1,
                                           SRR26643294.20378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050766 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000005.1  21841453-21841659   c
            208-554             JAXUCZ010000005.1  21838000-21838346   c
            555-686             JAXUCZ010000005.1  21834292-21834423   c
            687-786             JAXUCZ010000005.1  21825119-21825218   c
            787-931             JAXUCZ010000005.1  21821124-21821268   c
            932-1057            JAXUCZ010000005.1  21819998-21820123   c
            1058-1400           JAXUCZ010000005.1  21816394-21816736   c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..1400
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="short chain dehydrogenase/reductase family 16C,
                     member 5"
                     /db_xref="GeneID:297805"
                     /db_xref="RGD:1565999"
     exon            1..207
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="upstream in-frame stop codon"
     exon            208..554
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1151
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /EC_number="1.1.1.105"
                     /note="epidermal retinal dehydrogenase 2; retinal short
                     chain dehydrogenase reductase 2"
                     /codon_start=1
                     /product="epidermal retinol dehydrogenase 2"
                     /protein_id="NP_001423573.1"
                     /db_xref="GeneID:297805"
                     /db_xref="RGD:1565999"
                     /translation="MPCNLESAKDLLVFLGKSLLSILEALLSHVISKPRKNVAGEVVL
                     ITGAGSGLGRLLALQFARLGSVLVLWDVNKETNEETRQIAQEAGAIRVHAYTCDCSQR
                     EEVYRVADQVKKEVGDVSILINNAGIVTGRKFLDCPDDLMEKSLDVNFKAHLWMYKAF
                     LPAMIANNHGHLVCISSSAGLIGVNGLSDYCASKFAALGFAESMFVETLAQKQRGIKT
                     TIVCPFFIKTGMFEGCTTKCPNLLPILDPEYAVRKIVDAILQEQLYLYMPKFLYFIMF
                     LKSFLPIKTGILIADYLGLFHVMDGFTGQKKKS"
     misc_feature    345..1073
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="human 17-beta-hydroxysteroid dehydrogenase XI-like,
                     classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c;
                     cd05339"
                     /db_xref="CDD:187598"
     misc_feature    345..1073
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="human 17-beta-hydroxysteroid dehydrogenase XI-like,
                     classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c;
                     cd05339"
                     /db_xref="CDD:187598"
     misc_feature    order(360..362,366..377,432..440,510..518,594..602,
                     663..665,744..752,789..791,801..803,888..899,903..908)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187598"
     misc_feature    order(360..362,366..377,432..440,510..518,594..602,
                     663..665,744..752,789..791,801..803,888..899,903..908)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187598"
     misc_feature    order(525..527,537..539,633..638,645..650,657..659,
                     669..674,681..686,693..695,780..788,792..797,804..809,
                     816..821,825..833,837..842,906..914,1038..1043,1050..1052,
                     1062..1064)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(525..527,537..539,633..638,645..650,657..659,
                     669..674,681..686,693..695,780..788,792..797,804..809,
                     816..821,825..833,837..842,906..914,1038..1043,1050..1052,
                     1062..1064)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(666..668,750..752,789..791,801..803)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="active site"
                     /db_xref="CDD:187598"
     misc_feature    order(666..668,750..752,789..791,801..803)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="active site"
                     /db_xref="CDD:187598"
     misc_feature    order(693..695,702..704,831..833,840..842,858..860)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:187598"
     misc_feature    order(693..695,702..704,831..833,840..842,858..860)
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:187598"
     exon            555..686
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            687..786
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            787..931
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1057
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1400
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; RGD1565999"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtctccat gatccttacc actttctcag gaaaggacgc ctgcacgacg ccccaccccc
       61 gcgggatcac agtcccgccc ttcgcttggg ctccagccta ctcagggata aacatccgaa
      121 ccttgctgct taaccaggga cctgggtgcc tgaggcctaa gacgcctgca tctctccgtg
      181 gtggcaagaa agggaactgt ttgtgaggtg ttggccagaa catgccttgc aacctggaat
      241 cagcgaagga cttgcttgtt ttcttaggga agtcactgtt gagtattttg gaggctctac
      301 tttctcatgt catctcaaaa ccacggaaga atgttgctgg cgaagtagtc ctcatcacag
      361 gtgctgggag tggactcgga aggcttttag cattgcagtt cgcccgcctg ggatcagtgc
      421 tcgttctttg ggatgtgaac aaggagacaa atgaggagac ccgtcagata gctcaggaag
      481 caggagccat cagagtgcat gcctacacct gtgactgcag ccagagggaa gaagtataca
      541 gagtggccga ccaggttaag aaagaagttg gtgacgtctc tatcctcatc aacaatgctg
      601 gcattgtaac aggcagaaag ttcctcgatt gcccagatga cctcatggaa aagtcacttg
      661 atgtcaattt caaagcacat ttatggatgt ataaagcctt tctacctgcc atgattgcta
      721 acaaccatgg ccatttggtt tgcatttcaa gttcggctgg attgattgga gtaaatgggc
      781 tgtcagacta ttgtgcaagt aaattcgcag cccttggatt tgcagaatct atgtttgtcg
      841 aaacacttgc ccaaaaacaa agggggatca aaactactat tgtgtgccca ttctttataa
      901 aaactggaat gtttgaaggt tgcactacta agtgtcctaa tctgttacca attctggatc
      961 cagaatatgc agttaggaaa atagtagatg ctatccttca ggagcagctg tacttgtata
     1021 tgcccaagtt tttatacttc ataatgtttt taaaaagctt cttgcccatc aagacaggaa
     1081 tacttatagc tgactaccta ggactctttc atgtgatgga tggcttcact ggtcaaaaga
     1141 agaaatctta atgataaccc ctatgccctg tgttttctga gacccattgc tacgtcaggc
     1201 ttacttcaaa gaagaaaggt atttctgtcc gacagaaccc aaaaacaaat atgttctact
     1261 gtggaccatg atccttccag tgtcatttga atacaatgtt actgtttttt cttttgttgt
     1321 cgttgttgtt gttgaatgta ttttttgttt agttttggaa aataaaagta gctctttgtc
     1381 attcccactt caacaactat
//
LOCUS       NM_001436398            2629 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 5 (Cxcr5),
            transcript variant 2, mRNA.
ACCESSION   NM_001436398 XM_039080948
VERSION     NM_001436398.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Yi,H., Zhu,B., Zheng,C., Ying,Z. and Cheng,M.
  TITLE     CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte
            activation in rats by targeting NLRP3
  JOURNAL   Neuroreport 35 (6), 406-412 (2024)
   PUBMED   38526919
  REMARK    GeneRIF: CXCL13/CXCR5 promote chronic postsurgical pain and
            astrocyte activation in rats by targeting NLRP3.
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Cao,J., Hu,C., Ding,Z., Chen,J., Liu,S. and Li,Q.
  TITLE     Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats
  JOURNAL   Curr Mol Med 24 (7), 940-949 (2024)
   PUBMED   37622691
  REMARK    GeneRIF: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats.
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Luther,S.A., Ansel,K.M. and Cyster,J.G.
  TITLE     Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7
            ligands in lymph node development
  JOURNAL   J Exp Med 197 (9), 1191-1198 (2003)
   PUBMED   12732660
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Kouba,M., Vanetti,M., Wang,X., Schafer,M. and Hollt,V.
  TITLE     Cloning of a novel putative G-protein-coupled receptor (NLR) which
            is expressed in neuronal and lymphatic tissue
  JOURNAL   FEBS Lett 321 (2-3), 173-178 (1993)
   PUBMED   8386678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced XM_039080948.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2118127.1,
                                           SRR26643293.44883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000008.1  53742252-53742453   c
            203-2629            JAXUCZ010000008.1  53738878-53741304   c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2629
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="C-X-C motif chemokine receptor 5"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
     exon            1..202
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="upstream in-frame stop codon"
     exon            203..2629
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1270
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="isoform 2 is encoded by transcript variant 2;
                     chemokine (C-X-C motif) receptor 5; C-X-C chemokine
                     receptor type 5; CXC-R5; CXCR-5; neurolymphatic receptor;
                     burkitt lymphoma receptor 1 homolog; chemochine (C-X-C
                     motif) receptor 5"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 5 isoform 2"
                     /protein_id="NP_001423327.1"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
                     /translation="MPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVAD
                     LLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAV
                     HAYRRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQPHNNESLPQCIFSQENEAETR
                     AWFASRFLYHTGGFLLPMLVMAWCYVGVVHRLLQAQRRPQRQKAVRVAILVTSIFLLC
                     WSPYHIVIFLDTLERLKAVNSSCELSGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKF
                     RSDLSRLLTKLGCAGPASLCQLFPGWRKSSLSESENATSLTTF"
     misc_feature    311..1150
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="CXC chemokine receptor type 5, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CXCR5; cd15181"
                     /db_xref="CDD:341336"
     misc_feature    311..1150
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="CXC chemokine receptor type 5, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CXCR5; cd15181"
                     /db_xref="CDD:341336"
     misc_feature    311..388
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:341336"
     misc_feature    311..388
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:341336"
     misc_feature    order(323..325,470..472,479..481,527..529,536..541,
                     755..772,794..796,803..808,974..976,995..997,1004..1006,
                     1040..1042,1052..1054,1061..1066,1073..1075)
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="putative chemokine binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:341336"
     misc_feature    order(323..325,470..472,479..481,527..529,536..541,
                     755..772,794..796,803..808,974..976,995..997,1004..1006,
                     1040..1042,1052..1054,1061..1066,1073..1075)
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="putative chemokine binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:341336"
     misc_feature    407..484
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:341336"
     misc_feature    407..484
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:341336"
     misc_feature    515..607
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:341336"
     misc_feature    515..607
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:341336"
     misc_feature    641..709
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:341336"
     misc_feature    641..709
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:341336"
     misc_feature    794..883
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:341336"
     misc_feature    794..883
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:341336"
     misc_feature    905..997
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:341336"
     misc_feature    905..997
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:341336"
     misc_feature    1052..1129
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:341336"
     misc_feature    1052..1129
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:341336"
ORIGIN      
        1 tggcgctcag tgtagagata ctgattaact ctgaggacag gcaaacgtgc ctttaagcaa
       61 acctcctctc tgagcaagac acctctgtaa aataggagta agattccata cctcaagctc
      121 gtgtggatca aaccagatag gaggccgtct cctcagtttc agcaataatc aagaccggaa
      181 caaggggaga gaatcagagg aatacaagga actggccatc tacagtaaca gcacggagat
      241 ccccctacag gacagtatct tctgttctac agaggagggg cccctactga cttcctttaa
      301 gacgatattc atgcctgtgg cctacagcct catcttcctc ctgggtatga tgggaaacat
      361 cctcgtactg gtaatcctgg agaggcaccg gcacactcgg agctcaacgg agaccttcct
      421 gttccacctg gcagtagccg accttctctt ggtcttcatc ttgccttttg cagtggctga
      481 gggctctgtg ggttgggtcc tagggacctt cctctgcaaa actgtgatcg ccctgcacaa
      541 gatcaatttc tactgcagca gcctgctgct ggcctgcata gctgtcgacc gttatctggc
      601 catcgtccat gcggtccacg cctaccgccg ccgccgtctc ctctccatcc acatcacctg
      661 ctcgactatt tggctagccg gcttcctatt tgccttgcca gaactcctct ttgccaaggt
      721 tgtccaacct cataacaacg agtccttacc acagtgcatc ttctcccaag aaaatgaagc
      781 cgaaactaga gcctggttcg cctcccggtt tctctaccac actgggggct tcctgctacc
      841 gatgctcgtg atggcctggt gttatgtggg agtggtacac aggctattgc aggcccagcg
      901 gcgccctcag aggcagaagg cagtcagggt ggccatcttg gtgacaagca tcttccttct
      961 ctgctggtca ccctaccaca ttgtcatctt cctcgataca ctggaaaggc tgaaggctgt
     1021 gaacagcagt tgcgaattga gtggctacct ctcggtggct atcaccttat gtgaattcct
     1081 gggcctggct cactgctgtc tcaatcccat gctctacacc ttcgctggcg taaagttccg
     1141 cagtgacttg tctcggcttc tgaccaagct gggctgtgct ggcccggcct ccctttgtca
     1201 gctctttccg ggctggcgca agagcagtct ctctgagtca gagaacgcta cttctcttac
     1261 caccttctag atcccggggt ctcagccccc ggctctgttt ctgttttcct tgggagcata
     1321 aacgtggtgt tagaaacctg tctaacataa gctgggattc taagagctat tggggccagt
     1381 gtcccccagc tgggacggct agacaaactc tttctagaat gttcccaaag ctcttctgcc
     1441 agccctcagg ctagactaga gccacaggag gggaaagcgg cccaaaggca aggcaagcaa
     1501 tacccagacc acctatatcc ccttggacga agaggactcc acacacctcc catcttaaca
     1561 agctaaagtg aagactcagc tttatttctt cctggccata gggaaaagcc acctctgcct
     1621 gcggcacaca gtctcatctt cctcccaatt atgagctcag actctcctca gctaccgact
     1681 gctgcagctc cccattactc ctacaccact gaggaacagc cacctggcgg cagactgtgg
     1741 ccttaatgtg cctgtctcct aaatacagac gtatgccaga ccttcacccg tgcctttctc
     1801 ctaaccagca ggaacctgaa actgatctgc tttaggtagc tgtctgctcc aaccaaacca
     1861 ccactggatc agccccatgt tactggatct tggattacag actgagggca agttccagaa
     1921 ggtcctggaa ccttgccagt atcctgagaa gagtaaaggg caagcaagcc agcaggaaag
     1981 aggcccagtg gaaaaaaatg gaaagacacc ttttccaggc tccaaagagg aacaagtaaa
     2041 aatccaaccc agctgtcttc tccacccatg gaccaaagct tccagattgg cagggagatg
     2101 agatccaggg ccctagtgga ttctgggcac cgatggggaa ggaggtcaac tgcctgggga
     2161 aagtaagcct caggagaggg gacatttagc taagagaatg aagatagagg tccctgtctt
     2221 cattaggtag agacaaagtg agaagccgac ctgggtgggc aagtccccag gcccagggag
     2281 gcagtacctt gcacctggga gggtactact cagatagaac cagcggaaac tgctccacac
     2341 ctacttaggg gaagccagca ggcaactctg agctctgctt cctcccagcc actgatctag
     2401 gagggtgggg ggtggactga gggaagcaga gttgcctagc accactcaag tcaaccatac
     2461 aggctcccgg gggaccccac tggggaaatc aatgctatag ctccggagac tgtatcctca
     2521 ttgcagaatg gtggtgacac ctggggatcc ccttttctgc tcccagcttc tgacagccag
     2581 ctgggcagag gcgaaaccag acacagaaat aaaaatgcaa gagaaggca
//
LOCUS       NM_001436640            6788 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus PLAG1 zinc finger (Plag1), transcript variant 1,
            mRNA.
ACCESSION   NM_001436640 XM_008763525
VERSION     NM_001436640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6788)
  AUTHORS   Gu,Q. and Wei,H.F.
  TITLE     PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of
            Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin
            Signalling Pathway
  JOURNAL   Folia Biol (Praha) 68 (1), 25-32 (2022)
   PUBMED   36201855
  REMARK    GeneRIF: PLAG1 Promotes High Glucose-Induced Angiogenesis and
            Migration of Retinal Endothelial Cells by Regulating the
            Wnt/beta-Catenin Signalling Pathway.
REFERENCE   2  (bases 1 to 6788)
  AUTHORS   Hide,T., Takezaki,T., Nakatani,Y., Nakamura,H., Kuratsu,J. and
            Kondo,T.
  TITLE     Sox11 prevents tumorigenesis of glioma-initiating cells by inducing
            neuronal differentiation
  JOURNAL   Cancer Res 69 (20), 7953-7959 (2009)
   PUBMED   19808959
REFERENCE   3  (bases 1 to 6788)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
REFERENCE   4  (bases 1 to 6788)
  AUTHORS   Voz,M.L., Agten,N.S., Van de Ven,W.J. and Kas,K.
  TITLE     PLAG1, the main translocation target in pleomorphic adenoma of the
            salivary glands, is a positive regulator of IGF-II
  JOURNAL   Cancer Res 60 (1), 106-113 (2000)
   PUBMED   10646861
REFERENCE   5  (bases 1 to 6788)
  AUTHORS   Astrom,A.K., Voz,M.L., Kas,K., Roijer,E., Wedell,B., Mandahl,N.,
            Van de Ven,W., Mark,J. and Stenman,G.
  TITLE     Conserved mechanism of PLAG1 activation in salivary gland tumors
            with and without chromosome 8q12 abnormalities: identification of
            SII as a new fusion partner gene
  JOURNAL   Cancer Res 59 (4), 918-923 (1999)
   PUBMED   10029085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_008763525.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1115764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  21754093-21754272   c
            181-285             JAXUCZ010000005.1  21718307-21718411   c
            286-385             JAXUCZ010000005.1  21710736-21710835   c
            386-744             JAXUCZ010000005.1  21706208-21706566   c
            745-6788            JAXUCZ010000005.1  21699650-21705693   c
FEATURES             Location/Qualifiers
     source          1..6788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..6788
                     /gene="Plag1"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
     exon            1..180
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..285
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..385
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..744
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    494..496
                     /gene="Plag1"
                     /note="upstream in-frame stop codon"
     CDS             503..2002
                     /gene="Plag1"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein PLAG1; pleiomorphic adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1 isoform a"
                     /protein_id="NP_001423569.1"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
                     /translation="MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFN
                     SVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKC
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDD
                     GAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHS
                     SVSQLPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ"
     misc_feature    503..601
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    506..754
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Interaction with KPNA2. /evidence=ECO:0000250"
     misc_feature    566..577
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    608..670
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    608..670
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    623..1228
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Decreased nuclear import with localization in the
                     nucleus but also in the cytoplasm. /evidence=ECO:0000250"
     misc_feature    order(623..625,629..631,635..637,641..646,653..658,
                     665..667,713..715,719..721,731..736,743..748,755..757,
                     797..799,803..805,809..811,815..820,827..832,839..841)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(623..625,629..631,635..637,641..646,653..658,
                     665..667,713..715,719..721,731..736,743..748,755..757,
                     797..799,803..805,809..811,815..820,827..832,839..841)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    <674..919
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <674..919
                     /gene="Plag1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    692..760
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    692..760
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    737..805
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    737..805
                     /gene="Plag1"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    782..844
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    782..844
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    869..931
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    869..931
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    956..1018
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    956..1018
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(971..973,977..979,983..985,989..994,1001..1006,
                     1013..1015,1076..1078,1082..1084,1094..1099,1106..1111,
                     1118..1120,1160..1162,1166..1168,1172..1174,1178..1183,
                     1190..1195)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(971..973,977..979,983..985,989..994,1001..1006,
                     1013..1015,1076..1078,1082..1084,1094..1099,1106..1111,
                     1118..1120,1160..1162,1166..1168,1172..1174,1178..1183,
                     1190..1195)
                     /gene="Plag1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1061..1123
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1061..1123
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1145..1201
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1145..1201
                     /gene="Plag1"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1229..1999
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Activates transcription, Inhibition of nuclear
                     import due to lack of NLS and KPNA2 interaction.
                     /evidence=ECO:0000250"
     misc_feature    1229..1651
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Repression domain, contains 3 sumoylation motifs
                     and massively decrease transcription activity.
                     /evidence=ECO:0000250"
     misc_feature    1592..1702
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1652..1999
                     /gene="Plag1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T6.1);
                     Region: Massively activates transcription.
                     /evidence=ECO:0000250"
     exon            745..6788
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgcaagt tgagctgcag gggcagcgca tacactacaa tggctgctgg aaagaggcgt
       61 aaggaaacaa tttccaggcc cgccgcgtcc agcccgaaat atgagaaaaa aattattaga
      121 aattccgcgg gcggtgtaaa ggcggcggac gggccggagg gaggatgtta aagccccgcg
      181 gttgcctctc agtgctgcct tggtggtatt gggcacccag aatgcttcag tctgtaatga
      241 tctattaata aggtggccta actagagttt gcagcagggt ctcagattgg ccaaaatggg
      301 aagggatgga ttctgctctc ttccacgaag agttaatggg actggctaag atcaaagtct
      361 gaggcttttt tccatcacta atcagtccct ttttgctttc ttttacgacc acatgaaact
      421 tgagaagcca cctaaagcta aatcacttag tggagttggg cagttcccag gtgtccaacg
      481 agaaggcctg gtttaggctg cgatggccac tgtcattcct ggtgatttgt cagaagtaag
      541 agatacccag aaagcccctt cagggaaacg taagcgtggt gaaagcaaac caagaaaaaa
      601 ctttccttgc caactgtgtg acaaggcctt taacagtgtt gagaaattaa aggttcactc
      661 cttctctcac acgggagaga ggccctacaa gtgcacacac caagactgca ccaaggcctt
      721 tgtttctaag tacaaattac aaaggcacat ggctactcac tctcctgaga aaacccacaa
      781 gtgtaattat tgtgagaaaa tgtttcaccg gaaagaccat ctgaagaacc acctccatac
      841 acacgacccc aacaaagaga cttttaaatg cgaagagtgt ggcaagagct acaacaccaa
      901 gcttgggttt aagcgacact tggccttgca cgctgccacc agtggcgacc tcacctgcaa
      961 ggtgtgtttg cagacttttg agagcacagg tgtgctccta gagcacctga aatctcacgc
     1021 aggcaagtcc tctgggggcg tgaaagagaa aaagcaccag tgtgagcact gcgagcgcag
     1081 gttctacacc cggaaggatg ttcggagaca catggtggtg cacacgggaa gaaaggactt
     1141 cctctgtcag tactgtgcac agagatttgg acgaaaggat cacctcactc gacacatgaa
     1201 gaagagtcac aatcaagagc ttctgaaggt caaaactgaa ccagtcgatt tcctggaccc
     1261 attcacctgc aacatgtctg tgcctataaa agatgagctc ctgccggtca tgtccttgcc
     1321 ttccagcgaa ctcttgtcaa agccattcac caacactttg cagttaaacc tctataacac
     1381 tccatttcag tccatgcaga gctctgggtc tactcaccaa atgataacaa ctttaccttt
     1441 gggaatgacg tgccccatag atatggacac tgttcacccc tctcatcatc ttgctttcaa
     1501 atgcccgttc agttctacct catacgcaat ctctattccc gagaaagaac agcccttaaa
     1561 gggggaaatc gagagttatc tgatggagtt acaaggtggc gcaccatctt catcccagga
     1621 ttctcaagca tcatcgtcta agttagggtt agagcctcag agtggctccc cagacgatgg
     1681 tgctggggac ctctccctgt caaagagctc tatctctatc agtgaccccc tgaacacacc
     1741 agcattggat ttctctcagt tgttcaattt cataccatta aatggtcctc cttacaatcc
     1801 gctctccgtg ggaagccttg ggatgagcta ttcccaggac gaggcgcatt cttctgtttc
     1861 tcagctgccc acacaaacac aggatcttca ggatcctgcg aacacagtgg gccttggctc
     1921 tctgcactca ctgtcagcag ctttcaccag cagcctaagc tcaagcacta ccctgccccg
     1981 tttccaccag gcctttcagt agggtctggg ccgagggatt caccggaggt gcttgtgcag
     2041 ccccgcctgc aaagaccatt tatattctag tgcctacttt aacacaacac agaaacttct
     2101 ccttttgtat aatatcaggt tttatgaagc cagtaaatag gaattagcct ctttgataag
     2161 ctttgaaatg gttcgtgttt aactacgttt gctgtttctc ctgatttcct gccagttgtc
     2221 atagtctcgg agttttattt catagaggag cgccattatt atcactaaat tttacaagtc
     2281 ctgtgttcaa attactgtta gaccttaaca ttctcacttt tgtctaatag caatgggcat
     2341 tggacttttt tttttttgca aatgtgcagt acaatgtaaa tcttctatga aatgtgtgtg
     2401 aagaactgaa gtgtttcaca tttctttact agccactaaa tggattcata atcaagtgtg
     2461 ttttaaatga gttaagaatc cagtttgggg agagtatagt ggtttcctaa atacaccatc
     2521 atttgagatc aatatatttt gaagactgct attgtctggc taaaataaga agtttcagta
     2581 tctatttaat agaaacctag agatgttacg gggtgttctg tgttagaact agccctcagg
     2641 ctgatttgcc acatttcaac catctttccg ttaacagtgt gtggcctcgg agtcttcagg
     2701 atcagtgtag aagtgttctg ttgtatgccc ttcacctttc ataccccagg atggcttcac
     2761 aataccagca ttcttacttt gcatgttggt ccagttagtg cagagtctta gaaccattgt
     2821 gggacaatag acagtaaata tatgaagccc agagtggctg gctgcctgaa tcgtcggggt
     2881 gatagactcc tcaccaggaa gatggatgta aaacgtacag ccaaacccca gcacttgtct
     2941 agagaatgtc cactgttgcc agaactgaga actggactcc tatcgcatca cttctaaaac
     3001 agcagtcttg cccgtgcgcc cttgctcagt gcatatacat ctttccctgc cgtgtttgga
     3061 tggagaactt aaaaattaaa cacatcaaaa agcaacttga cgagttccac agttttacac
     3121 caccaaaagt tgttaagagc ccacttttac acatctccag gagacaggag gaatgttaga
     3181 aataagttga atttatagag gaaacagagg aaaataaagc aaacaccaaa tgaatacgaa
     3241 tgcaccaagg atgtggtgct cactgagcaa ggtagcaatg ggcttcctct tgtcagacag
     3301 ccaccaagaa tgtcatcggt agctccgcgt atatcttcct aagggttatt tgtggcatca
     3361 acctacgaga cttactaagc acttgttaac accttattct ggaccccttc tgttggggca
     3421 gggagtttta tagaagagta tatatctctt taaaaaaaaa aaaaaggaag aaactatttt
     3481 ttaatctctg agcactcgtt agccctggct ggggaagctt cttcccttgt gtaagggcca
     3541 gttatcactg catattgtat tgtttaccca tcactctaag cataaacaga ttactgacta
     3601 tgatgcatta tttacaatgc ctgggagtag tctaaattga gaagtgtaaa ctgtcctgtg
     3661 aatggggctt tcactatatg tcatacacac gcctagtgca cttcatagaa tcagagctgc
     3721 tccctagagg gctcaagctc ctggttctaa ccctagagca gtagttttta tacgtatgta
     3781 tttaaatttt attgtgaaaa atacatttta ttaaagaaag tgttccaaag gcattaaaat
     3841 tatatacgtt aataaggaaa tacattttaa ctcttcaagc tgctcctgag ctgagggtgg
     3901 gagcgcactc actcagaaag tgggctcttc gcatgaccgc ttccttagtt tctatgaaac
     3961 cgatcacgta ccctaatgtt ctagttggat gattagtgtt caatattgct ttaatcacca
     4021 cttttaaaag gagaggacat ttggtgacag agcacaagta aataaaaaaa cctattatta
     4081 tgtagagttc acagacacca catatgaaag cactagttta ttctatctaa aaattactta
     4141 agaagtcaca tttatgacct gagacgttgg ccttcgtagg ctgtatatat ttcactgcta
     4201 attgaaaaaa gggagtacca ggatatatga aataaagcat ttcgcaatgg gaatggcgcc
     4261 atatatgtgt gtgtgtgtat atatatatat atatgtatgt atatatatat atataataaa
     4321 tatattttta tcctaattct tgcccagcgc agaactctaa tacacatctt ccagggtacc
     4381 agtgttaaaa cgtagagtct tactttcctt tgtatgtaca cctctttgcc tgttgctgcc
     4441 cccacagact tgaatgacat ttcaaagtaa gagggaaata agcaaattct tttcgcttta
     4501 ttgactgcag tggtcactaa accctttttt gatagatttt atattaaaaa tcagtcagct
     4561 tttttatttt cattgcacaa tgttttaaca ggaacgcaac acagaattgg caacccctac
     4621 cccatggaaa atactgtcac tcgttctgtc tgaagtagga ctgcttagca ataggccttg
     4681 ctagtgccct tctcattctc catggtcctc gggatttctg atagtgcctt agcttaaaag
     4741 aaaaggggtt aacattaact aaacagtgta gtgtagagtt tggacctcag acaagatgct
     4801 gggccccgtt cattttgact tccacacatg tgtgtgcagc ttcaggagtg tgagcgcctt
     4861 ttcaggaaag gtctggcact gtgagcaata tagtccattg atatttacca ataaatacca
     4921 cctctgtagt taatgtctct taagcttccg tttaaaatcc cgttacttgt tgaggtttct
     4981 aaaatgtaag ttgccttggc agatcatgca ccagtctgtg tgcagctttt ttcccttttt
     5041 aatttcagtt ggcgtttctt tcaagctgtg tgtgtttgcc tatgtgtcgc ttgcgcttta
     5101 tttttctagt catttgtgga atatagtgat atattgtgtt aatttggaca gtgacggttt
     5161 tttgaaacca tatactgact gaaacatgag ccagagctga ttgctttatt aagctaataa
     5221 tgaatgttat agagtacata tttcaggatc attcatctag tgagcagtac acatataggc
     5281 caattaaaaa aaaatagagc ttggtcaacc tctatacttc acatactaca agatatagca
     5341 ctttcaaaat gaacctaaat ttctacagaa actttcctat atgttatgcc ttttattttt
     5401 aagacttatt atattcattt caagtgccat tagacgatat atccgtaggc ctttgatata
     5461 taatgctttg tgtacaaaga atagtagatg gtattttaaa caggtacatt tttacagtgt
     5521 tttcctatcg atttgctata ttgcacagaa tcagtgtgtg tcctttcata aggttttaca
     5581 atggtttatt tttttacaag gtttacgtat ctcaaagcac actgtcttcc cagtccataa
     5641 gtaagttaaa agataccagt tcacccaagt tgcttctagc ctactgcgat ccatgtgaca
     5701 ttgaaggaga tctttgcagt gttgaatatt cgcccttcat gaaggcaggc tggttttttt
     5761 tcctgacaaa tgagttcgtt ggtgaatttg tctcgtttta ctcatgatgt cagcagccgg
     5821 gtctaccaca caacatagct tgattgtgta agcctccgta aataccttaa attgtattgt
     5881 acccacagag cactcctctg agattaagca agctaatgcc atcagccttc atagcaggca
     5941 cggatcacca ataagccttt ctacaatgtt agcagcccct ggagatggaa ggcagtgtct
     6001 tttgataagt tatctatctc tatagatgac acaggattat tactgatgta taagacactt
     6061 cattgtataa gcttcagtgg tacagatgaa ccagaatgaa tgtctgtctt ctcagaagcc
     6121 ctccttcaac gttctatggg atcatgctgc tactgtcact tgggatacaa ctcttcatgg
     6181 tgctacaaac ttctgtctca ttcacttgta tttttttacc cataggaaaa ggactctata
     6241 ggtgtaaagg tgtacaatat atttttatac tgtgacttaa attgtcatta acaaactttt
     6301 acaccaccac agtgtactca tgtgcgcttg caaaaggaga tcttggatgt gcaaatgtta
     6361 ccagaacaaa cccagctttt gtccacaagg tgactgtaac tcagaatgga aagtgagctt
     6421 gacatagggt gtggagtgaa gaacatgcta taagttacta acagcccttt gaatttaaca
     6481 aaaactggga atccattaga gaaatggatt gcatcatgcc tgaacataag ctgactgctg
     6541 aaatattttt ttttagctaa tgaaaaagtg tttggactag tgtactctaa aaaatgtttt
     6601 aatggtaaag ttttgagtca aatagaaatg aaaaaaaatc tgcattccag acttaatttt
     6661 gtatattttt attgcctttt aaattgctat tctgtgatat tgggaaatca agtggcttat
     6721 catgtatatc atgtacttaa aatgtattca caaactactg ttgtatttgt ataaaatata
     6781 gacaaaga
//
LOCUS       NM_053303               2546 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus C-X-C motif chemokine receptor 5 (Cxcr5),
            transcript variant 1, mRNA.
ACCESSION   NM_053303
VERSION     NM_053303.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Yi,H., Zhu,B., Zheng,C., Ying,Z. and Cheng,M.
  TITLE     CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte
            activation in rats by targeting NLRP3
  JOURNAL   Neuroreport 35 (6), 406-412 (2024)
   PUBMED   38526919
  REMARK    GeneRIF: CXCL13/CXCR5 promote chronic postsurgical pain and
            astrocyte activation in rats by targeting NLRP3.
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Cao,J., Hu,C., Ding,Z., Chen,J., Liu,S. and Li,Q.
  TITLE     Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats
  JOURNAL   Curr Mol Med 24 (7), 940-949 (2024)
   PUBMED   37622691
  REMARK    GeneRIF: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats.
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   4  (bases 1 to 2546)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   5  (bases 1 to 2546)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   6  (bases 1 to 2546)
  AUTHORS   Luther,S.A., Ansel,K.M. and Cyster,J.G.
  TITLE     Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7
            ligands in lymph node development
  JOURNAL   J Exp Med 197 (9), 1191-1198 (2003)
   PUBMED   12732660
REFERENCE   7  (bases 1 to 2546)
  AUTHORS   Kouba,M., Vanetti,M., Wang,X., Schafer,M. and Hollt,V.
  TITLE     Cloning of a novel putative G-protein-coupled receptor (NLR) which
            is expressed in neuronal and lymphatic tissue
  JOURNAL   FEBS Lett 321 (2-3), 173-178 (1993)
   PUBMED   8386678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 11, 2025 this sequence version replaced NM_053303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.31383.1,
                                           SRR26643292.33377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000008.1  53753525-53753643   c
            120-2546            JAXUCZ010000008.1  53738878-53741304   c
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2546
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="C-X-C motif chemokine receptor 5"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
     exon            1..119
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    45..47
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="upstream in-frame stop codon"
     CDS             63..1187
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chemokine (C-X-C motif) receptor 5; C-X-C chemokine
                     receptor type 5; CXC-R5; CXCR-5; neurolymphatic receptor;
                     burkitt lymphoma receptor 1 homolog; chemochine (C-X-C
                     motif) receptor 5"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 5 isoform 1"
                     /protein_id="NP_445755.2"
                     /db_xref="GeneID:29363"
                     /db_xref="RGD:62010"
                     /translation="MNYPLTLDIDSITYNMDELYKELAIYSNSTEIPLQDSIFCSTEE
                     GPLLTSFKTIFMPVAYSLIFLLGMMGNILVLVILERHRHTRSSTETFLFHLAVADLLL
                     VFILPFAVAEGSVGWVLGTFLCKTVIALHKINFYCSSLLLACIAVDRYLAIVHAVHAY
                     RRRRLLSIHITCSTIWLAGFLFALPELLFAKVVQPHNNESLPQCIFSQENEAETRAWF
                     ASRFLYHTGGFLLPMLVMAWCYVGVVHRLLQAQRRPQRQKAVRVAILVTSIFLLCWSP
                     YHIVIFLDTLERLKAVNSSCELSGYLSVAITLCEFLGLAHCCLNPMLYTFAGVKFRSD
                     LSRLLTKLGCAGPASLCQLFPGWRKSSLSESENATSLTTF"
     misc_feature    144..146
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P34997.1); glycosylation site"
     misc_feature    222..1067
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="CXC chemokine receptor type 5, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CXCR5; cd15181"
                     /db_xref="CDD:341336"
     misc_feature    222..1067
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="CXC chemokine receptor type 5, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CXCR5; cd15181"
                     /db_xref="CDD:341336"
     misc_feature    222..305
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:341336"
     misc_feature    222..305
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:341336"
     misc_feature    234..296
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    order(240..242,387..389,396..398,444..446,453..458,
                     672..689,711..713,720..725,891..893,912..914,921..923,
                     957..959,969..971,978..983,990..992)
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="putative chemokine binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:341336"
     misc_feature    order(240..242,387..389,396..398,444..446,453..458,
                     672..689,711..713,720..725,891..893,912..914,921..923,
                     957..959,969..971,978..983,990..992)
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="putative chemokine binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:341336"
     misc_feature    324..401
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:341336"
     misc_feature    324..401
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:341336"
     misc_feature    333..395
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    432..524
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:341336"
     misc_feature    432..524
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:341336"
     misc_feature    441..503
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    558..626
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:341336"
     misc_feature    558..626
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:341336"
     misc_feature    570..632
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    654..656
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P34997.1); glycosylation site"
     misc_feature    711..800
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:341336"
     misc_feature    711..800
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:341336"
     misc_feature    726..788
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    822..914
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:341336"
     misc_feature    822..914
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:341336"
     misc_feature    846..908
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     misc_feature    969..1046
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:341336"
     misc_feature    969..1046
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:341336"
     misc_feature    981..1043
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P34997.1);
                     transmembrane region"
     exon            120..2546
                     /gene="Cxcr5"
                     /gene_synonym="Blr1; NLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctggcat cgaccttctc agcatcagac agtgaccagc ctggtgacgc agagctgtag
       61 cgatgaacta cccactaacc ttggacatag actccatcac ctacaacatg gatgagctgt
      121 acaaggaact ggccatctac agtaacagca cggagatccc cctacaggac agtatcttct
      181 gttctacaga ggaggggccc ctactgactt cctttaagac gatattcatg cctgtggcct
      241 acagcctcat cttcctcctg ggtatgatgg gaaacatcct cgtactggta atcctggaga
      301 ggcaccggca cactcggagc tcaacggaga ccttcctgtt ccacctggca gtagccgacc
      361 ttctcttggt cttcatcttg ccttttgcag tggctgaggg ctctgtgggt tgggtcctag
      421 ggaccttcct ctgcaaaact gtgatcgccc tgcacaagat caatttctac tgcagcagcc
      481 tgctgctggc ctgcatagct gtcgaccgtt atctggccat cgtccatgcg gtccacgcct
      541 accgccgccg ccgtctcctc tccatccaca tcacctgctc gactatttgg ctagccggct
      601 tcctatttgc cttgccagaa ctcctctttg ccaaggttgt ccaacctcat aacaacgagt
      661 ccttaccaca gtgcatcttc tcccaagaaa atgaagccga aactagagcc tggttcgcct
      721 cccggtttct ctaccacact gggggcttcc tgctaccgat gctcgtgatg gcctggtgtt
      781 atgtgggagt ggtacacagg ctattgcagg cccagcggcg ccctcagagg cagaaggcag
      841 tcagggtggc catcttggtg acaagcatct tccttctctg ctggtcaccc taccacattg
      901 tcatcttcct cgatacactg gaaaggctga aggctgtgaa cagcagttgc gaattgagtg
      961 gctacctctc ggtggctatc accttatgtg aattcctggg cctggctcac tgctgtctca
     1021 atcccatgct ctacaccttc gctggcgtaa agttccgcag tgacttgtct cggcttctga
     1081 ccaagctggg ctgtgctggc ccggcctccc tttgtcagct ctttccgggc tggcgcaaga
     1141 gcagtctctc tgagtcagag aacgctactt ctcttaccac cttctagatc ccggggtctc
     1201 agcccccggc tctgtttctg ttttccttgg gagcataaac gtggtgttag aaacctgtct
     1261 aacataagct gggattctaa gagctattgg ggccagtgtc ccccagctgg gacggctaga
     1321 caaactcttt ctagaatgtt cccaaagctc ttctgccagc cctcaggcta gactagagcc
     1381 acaggagggg aaagcggccc aaaggcaagg caagcaatac ccagaccacc tatatcccct
     1441 tggacgaaga ggactccaca cacctcccat cttaacaagc taaagtgaag actcagcttt
     1501 atttcttcct ggccataggg aaaagccacc tctgcctgcg gcacacagtc tcatcttcct
     1561 cccaattatg agctcagact ctcctcagct accgactgct gcagctcccc attactccta
     1621 caccactgag gaacagccac ctggcggcag actgtggcct taatgtgcct gtctcctaaa
     1681 tacagacgta tgccagacct tcacccgtgc ctttctccta accagcagga acctgaaact
     1741 gatctgcttt aggtagctgt ctgctccaac caaaccacca ctggatcagc cccatgttac
     1801 tggatcttgg attacagact gagggcaagt tccagaaggt cctggaacct tgccagtatc
     1861 ctgagaagag taaagggcaa gcaagccagc aggaaagagg cccagtggaa aaaaatggaa
     1921 agacaccttt tccaggctcc aaagaggaac aagtaaaaat ccaacccagc tgtcttctcc
     1981 acccatggac caaagcttcc agattggcag ggagatgaga tccagggccc tagtggattc
     2041 tgggcaccga tggggaagga ggtcaactgc ctggggaaag taagcctcag gagaggggac
     2101 atttagctaa gagaatgaag atagaggtcc ctgtcttcat taggtagaga caaagtgaga
     2161 agccgacctg ggtgggcaag tccccaggcc cagggaggca gtaccttgca cctgggaggg
     2221 tactactcag atagaaccag cggaaactgc tccacaccta cttaggggaa gccagcaggc
     2281 aactctgagc tctgcttcct cccagccact gatctaggag ggtggggggt ggactgaggg
     2341 aagcagagtt gcctagcacc actcaagtca accatacagg ctcccggggg accccactgg
     2401 ggaaatcaat gctatagctc cggagactgt atcctcattg cagaatggtg gtgacacctg
     2461 gggatcccct tttctgctcc cagcttctga cagccagctg ggcagaggcg aaaccagaca
     2521 cagaaataaa aatgcaagag aaggca
//
LOCUS       NM_001436628            4115 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus DDHD domain containing 2 (Ddhd2), transcript
            variant 1, mRNA.
ACCESSION   NM_001436628 XM_001059724
VERSION     NM_001436628.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4115)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (bases 1 to 4115)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (bases 1 to 4115)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (bases 1 to 4115)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_001059724.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32947.1,
                                           SRR26643298.71944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000016.1  73022193-73022329
            138-363             JAXUCZ010000016.1  73023386-73023611
            364-554             JAXUCZ010000016.1  73024257-73024447
            555-644             JAXUCZ010000016.1  73025595-73025684
            645-765             JAXUCZ010000016.1  73026637-73026757
            766-855             JAXUCZ010000016.1  73027465-73027554
            856-991             JAXUCZ010000016.1  73029229-73029364
            992-1200            JAXUCZ010000016.1  73033702-73033910
            1201-1268           JAXUCZ010000016.1  73034155-73034222
            1269-1391           JAXUCZ010000016.1  73035946-73036068
            1392-1487           JAXUCZ010000016.1  73036977-73037072
            1488-1571           JAXUCZ010000016.1  73038456-73038539
            1572-1727           JAXUCZ010000016.1  73038642-73038797
            1728-1830           JAXUCZ010000016.1  73039438-73039540
            1831-2001           JAXUCZ010000016.1  73039664-73039834
            2002-2161           JAXUCZ010000016.1  73041377-73041536
            2162-2268           JAXUCZ010000016.1  73049473-73049579
            2269-4115           JAXUCZ010000016.1  73049900-73051746
FEATURES             Location/Qualifiers
     source          1..4115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4115
                     /gene="Ddhd2"
                     /note="DDHD domain containing 2"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
     exon            1..137
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..363
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2243
                     /gene="Ddhd2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phospholipase DDHD2"
                     /codon_start=1
                     /product="phospholipase DDHD2 isoform 1"
                     /protein_id="NP_001423557.1"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
                     /translation="MSSGESYQEQLSQSDPSPSPNSSSSFELLDMDVGSSYEPVSPHW
                     FYCKVIDSKELWIPFNSEDSQQLEEAHGSGKDCNERVVPTDGGRYDVHLGERMRYAVY
                     WDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKLESPNREI
                     IVLHNPKLMVHYQPITGSDEWGSTSTEQGRPRSVKRGVESIPVDIHCGEPLQIDHLVF
                     VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPL
                     HSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLF
                     LQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSIGDIDSEKGSLSTAEDLGDVSTLEE
                     ELKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSATKSSVGI
                     NRPTMSASEVNIPKEKGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLR
                     RIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELRE
                     GLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASEMAEDTEAESEPSSEKPSDANTE
                     EPPVEVKEEAPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLV
                     LKEIYQTQGIFLDQPLQ"
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    270..479
                     /gene="Ddhd2"
                     /note="WWE domain; Region: WWE; pfam02825"
                     /db_xref="CDD:460715"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1278..1484
                     /gene="Ddhd2"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1593..2204
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    1593..2204
                     /gene="Ddhd2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     exon            364..554
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..644
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..765
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..855
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..991
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1200
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1268
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1391
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1487
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1571
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1727
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1830
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2001
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2161
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2268
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..4115
                     /gene="Ddhd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctcagg ccctgaaccg ggtgagcgga ctccgcaggg ctcactgctc gcggctggat
       61 cgctgaggag cccgtggtgc gggattgggg cgcggccaca ggctccgccc gtctgcccgc
      121 cccgcccggc ttgggagagc gaaatgtcat caggggaatc gtaccaggag cagctgtcac
      181 agtcagatcc atccccctcc ccaaactcca gtagttcctt cgagctgcta gacatggatg
      241 ttggcagttc ctacgaaccc gtttctccac attggtttta ttgtaaggta atagactcta
      301 aggaactctg gattcctttc aactctgaag attcacagca gctggaagaa gcacatggct
      361 ctggaaagga ttgtaatgag agagttgtcc ccactgatgg gggcagatat gatgtccatc
      421 tcggggagag gatgcggtat gccgtgtact gggatgaact accatcagaa gtgagacggt
      481 gcacgtggtt ttacaaggga gacaaagaca ataagtacgt cccctactcc gagagcttca
      541 gccaagtttt ggaggataca tatatgcttg cggtaactct ggatgaatgg aaaaaaaaac
      601 tagagtctcc aaacagagaa attattgtat tacacaaccc aaagctcatg gtgcattacc
      661 agccaatcac agggtctgat gaatggggtt caacatccac tgagcaaggt cggccaagat
      721 cagtaaaaag aggcgttgag agcatccctg ttgatattca ctgtggggaa cctttacaaa
      781 tagatcactt agtgtttgta gtccatggga ttggaccagc ttgtgatctc cgttttcgaa
      841 gcattgttca atgtgttaat gattttcgaa gtgtttcctt gaacctgcta caaacacatt
      901 ttaagaaagc ccaagaaaac cagcagattg gaagggtaga gttccttccg gtcaactggc
      961 acagcccttt gcattctact ggagtagata tagatctgca gcggataacc ctacccagca
     1021 tcaatcgcct tagacacttc actaacgata caattctgga tgtcttcttc tacaatagcc
     1081 ccacctactg tcagactatt gtggacacag tagcttctga aatgaaccga atatatacac
     1141 tttttctgca gaggaaccct gatttcaaag ggggtgtatc cattgctggt catagtttag
     1201 gttcgcttat attgtttgat atcctaacaa atcagaaaga ttctattggg gatattgaca
     1261 gtgaaaaggg ttcattgagt actgctgagg atctaggaga tgtatcaaca ttagaagaag
     1321 aactgaagaa gcttcagctc tctgagtttg tcactgtctt tgagaaggag aaagttgaca
     1381 gagaagctct ggctttatgt acagacagag atcttcagga aatggggatt cccttaggac
     1441 ccagaaagaa gatactgaac cacttcagtg ccacaaagag ttcagtgggt attaatagac
     1501 caaccatgtc agcttctgag gtaaatatcc ccaaggaaaa aggtgactat ttggatgttg
     1561 gaattgggca ggtgtctgta aaataccccc ggcttaacta caaaccagaa atattctttg
     1621 cctttggatc tcccattgga atgtttctta ctgtccgagg attaagaaga attgatccaa
     1681 attataaatt tcccacatgc aaaggtttct tcaatattta ccatcctttt gatcctgtgg
     1741 catataggat tgaaccaatg gtggtcccag gagtagaatt tgagccaatg ctgattccac
     1801 atcataaagg caggaagcgg atgcacttag aactgagaga gggcttgacc aggatgagta
     1861 tggacctgaa gaacaacttg ctgggttcac tgaggatggc ctggaagtct ttcaccagag
     1921 ctccataccc tgccttacaa gcttcagaaa tggcagaaga cactgaggca gaatccgaac
     1981 caagttcaga aaagcccagt gacgccaaca cagaagagcc tcctgtggag gtcaaagagg
     2041 aggctcccat caatgtggga atgctgaatg gaggccagcg cattgactat gtgttacagg
     2101 agaagcccat tgagagtttt aatgaatatt tatttgctct acaaagccat ctatgctact
     2161 gggaatctga agatacagta ctgcttgtcc tcaaagagat ctaccaaacc caggggatct
     2221 tccttgatca gcctttacag taaaatgacc catctgtggc tgcttaatat ggacattgag
     2281 ggagcctttc ctgaaaaccc cctcacttgt tgctgcagct ttcttctcag ctaccgtgtg
     2341 tcctgcatgt tgcctgcctt actccacggg atctttcaag ataaccctct ttggaaacta
     2401 ggtgaaagca gagggaagac tgcctcatat gaactctcgc catttttgta gctagggact
     2461 tccatattta atgctttagc agcagcccct ccttggttat tacatggaaa tggatagtct
     2521 gttaaggggg cttagagagc tttatgtcct ctccttagaa agtgggcccg ttggggagct
     2581 tatgaagatg gagaggactt aggggtccag tcgcactgga gggctaagca tgtgtggatg
     2641 tgggatagct gctaggtttt gagccagcat ttatttcttt gctgtgtgtg aaaaccagag
     2701 gctgccctga gcactcacat ggcactgtag ggaccactgg ggctgtttgt ggttgttata
     2761 gttgcctcag cgtctgtaac cccagaggct gtatgggctg tgtgcctgcc cttctacacc
     2821 atactccaaa ccagggtgaa gtgcagggag tgaggtggta atacttactt gaaggtcacc
     2881 ctgaagttac atggtccttc tcagctgttc atgtagaaaa tgtggttttt tagtagcacg
     2941 gacttgtcac ctgcttcttc acttgagaaa aggaagtatt gtgacataaa cgtcactgct
     3001 ttctgaggta tcatcaaaat gtttacttat agttggcagt cagtgtagtt gagcatgcag
     3061 gttaggcaag ggggaagacc acattctgaa agaaaatcct gtctacaggg tctgaggagc
     3121 agctgtatac actgtgcagt ggcagctgaa tctgcagaat tcaaagcacg tttatcctga
     3181 ggaagaatga ctgtatactg tcttcccctt cctcagcatg tgctgtcgtc cgtcctcttc
     3241 atgattgtcc tttattctcc ttagttagct cctccgattt ccacaggtct ctttataggt
     3301 gagctgtggt ttgatttttg accttttttt gtaaactgat catggtatcc agaggcactg
     3361 cacataacac gccctgaagc ccctcagatg gtggtgccct tgacacaccg ggagagggag
     3421 gcgagcactg tgccctggag gtcagaggca caggacagtc aggcctggcc ttcctttctg
     3481 cttatgggta atactggata agcaagctac tgaggagttc caggtatatg gaatatttta
     3541 ttttttctac agtatgtctt gagtaagaat atctgagaat gaagtagtat tcattaaata
     3601 ctagagtaat tttgtcaatt gttgtcttga gatttgttta ctcttgttag cagtcattac
     3661 tatgttaaga gtaaaccaaa gcacaactga gtgtgttctt gtgaccaaag atgggcagct
     3721 tggccctgga gagctagata aaccactgca ctaagaaatg ctgcttcccg gcagtccagt
     3781 acagtaactc aaagagcttg cacctcacca tccactcgtg gcgttatcac gctcagtatt
     3841 acacaagtga gtagggcaag gggcctgggt acgggtgtgc attgcgtcat ttgttaccat
     3901 gtacagtttc ttgaccaagg ctgtttttaa actccagtgt aacagcattt tgtacgtaat
     3961 tctggctaca caattcgtga gagactgttt gcaagggatg aacagcactg attaccttcc
     4021 tgatattttg cacttttgaa atgttttgtt ttatatgtga ttatatttaa gactttagta
     4081 aatgctgaaa taaaactatt gaccatttac ctaca
//
LOCUS       NM_001436645            4070 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus chondroitin sulfate
            N-acetylgalactosaminyltransferase 1 (Csgalnact1), transcript
            variant 1, mRNA.
ACCESSION   NM_001436645 XM_017600096
VERSION     NM_001436645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Sato,T., Kudo,T., Ikehara,Y., Ogawa,H., Hirano,T., Kiyohara,K.,
            Hagiwara,K., Togayachi,A., Ema,M., Takahashi,S., Kimata,K.,
            Watanabe,H. and Narimatsu,H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is
            necessary for normal endochondral ossification and aggrecan
            metabolism
  JOURNAL   J Biol Chem 286 (7), 5803-5812 (2011)
   PUBMED   21148564
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Watanabe,Y., Takeuchi,K., Higa Onaga,S., Sato,M., Tsujita,M.,
            Abe,M., Natsume,R., Li,M., Furuichi,T., Saeki,M., Izumikawa,T.,
            Hasegawa,A., Yokoyama,M., Ikegawa,S., Sakimura,K., Amizuka,N.,
            Kitagawa,H. and Igarashi,M.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required
            for normal cartilage development
  JOURNAL   Biochem J 432 (1), 47-55 (2010)
   PUBMED   20812917
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Gotoh,M., Sato,T., Akashima,T., Iwasaki,H., Kameyama,A.,
            Mochizuki,H., Yada,T., Inaba,N., Zhang,Y., Kikuchi,N., Kwon,Y.D.,
            Togayachi,A., Kudo,T., Nishihara,S., Watanabe,H., Kimata,K. and
            Narimatsu,H.
  TITLE     Enzymatic synthesis of chondroitin with a novel chondroitin sulfate
            N-acetylgalactosaminyltransferase that transfers
            N-acetylgalactosamine to glucuronic acid in initiation and
            elongation of chondroitin sulfate synthesis
  JOURNAL   J Biol Chem 277 (41), 38189-38196 (2002)
   PUBMED   12163485
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_017600096.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55942.1,
                                           SRR26643285.50466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000016.1  25762253-25762375
            124-182             JAXUCZ010000016.1  25772977-25773035
            183-317             JAXUCZ010000016.1  25843836-25843970
            318-466             JAXUCZ010000016.1  25915023-25915171
            467-1394            JAXUCZ010000016.1  26002429-26003356
            1395-1611           JAXUCZ010000016.1  26052126-26052342
            1612-1713           JAXUCZ010000016.1  26065782-26065883
            1714-1892           JAXUCZ010000016.1  26079602-26079780
            1893-1987           JAXUCZ010000016.1  26080645-26080739
            1988-2069           JAXUCZ010000016.1  26091895-26091976
            2070-4070           JAXUCZ010000016.1  26095306-26097306
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4070
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
     exon            1..123
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            124..182
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            183..317
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            318..466
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1394
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    758..760
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="upstream in-frame stop codon"
     CDS             767..2359
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /EC_number="2.4.1.174"
                     /note="chondroitin beta1,4
                     N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="chondroitin sulfate
                     N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_001423574.1"
                     /db_xref="GeneID:306375"
                     /db_xref="RGD:1307618"
                     /translation="MVRRGLVGWISRVVILLVLLCCAISVLYMLACTPKGDQEQLGLP
                     RANGPTGKDGYQAVLQEREEQHRNYVNSLKRQIAQLKDELQARSEQLRSGQDQASDAT
                     SLRSGWDPEPKAQADILAFLRGQVDKAEVHAGVKLATEYAAVPFDSFTLQKVYQLETG
                     LTRHPEEKPVRKDKRDELVEAIESALESLNSPVESSPHQRPYTAADFIEGIYRTERDK
                     GTLYELTFKGDHKHEFQRLVLFRPFGPIMKVKKEKLNMANTLINVIVPLARRVDKFRH
                     FMQNFREMCIQQDGRVHLTVVYFGKEEMNEVKGILENTSKAANFRNFTFIQLNGEFSR
                     GKGLDVGARFWKGSNVVLFFCDVDIYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGI
                     IYGHHDAVPALEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGGFDLDIKGWGGEDVH
                     LYRKYLHSNLIVIRTPVRGLFHLWHEKHCMDELTPEQYRMCMQSKAMNEASHGQLGML
                     VFRHEIEAHLRKQKLKASSKKT"
     misc_feature    968..2281
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     misc_feature    968..2281
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     Region: CHGN; pfam05679"
                     /db_xref="CDD:461712"
     exon            1395..1611
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1713
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1892
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1987
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2069
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..4070
                     /gene="Csgalnact1"
                     /gene_synonym="Chgn; RGD1307618"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgttgga actggaggtg gagccgagcc cagggccgcc tcgcaggagg gaaagttcgg
       61 cggcgccggg cgggagcagc gtagccaagg gagccggctc cgctgtctgc agggttgctt
      121 ggggtctcgt tttcctcctg gaatacagcg tgtgcagatg gatcaaagtt acctactata
      181 aagtcccttg atcatgaatg acagattgaa gagttgccat gtggatctac agtcctcaat
      241 gtgagaagct ttaaacaatc ttttctatgg ctggaatcct caaatgttct acttaattgc
      301 ctctggagca tcaccagtgg tggcgctgag ctgaacacgg tgctagcaga agggggcggt
      361 actttccctc tggaccctga cttggaagcc aagtgcgact cgagcgcagt caccgccaga
      421 agcagatgtg tgagcggagc agctgtgcgc ctctctttct gccgaggatc cccctcatct
      481 tcagcacatc aggaagacta tgatggaaac aaaagaaaga acttggaggt tccacttaac
      541 tgattgtttc tgcctagagg atcttctctt ggaagcagga gagccttctc atgtaatggc
      601 tgacttccaa agacaggcta tgttctagaa ggaaatggat ggaatcagtt caggggactt
      661 cagccgcact gtggtctaac cagaaaagcc cgtgttgggg gccctcctgg tgccctggga
      721 tgttgcatac tctggacctg gatgcatggc ccgcacctga gtgaggatgg tccgacgcgg
      781 gctggtgggg tggatttccc gggtagtgat tctgctggtg ctgctctgtt gtgccatctc
      841 tgttctctac atgttagcct gcaccccaaa aggcgaccaa gagcagctgg gactgccacg
      901 ggccaacggc cccacaggca aagatggcta ccaagcggtg ctacaggagc gtgaggaaca
      961 gcatcgcaac tatgtgaata gtcttaagcg acagatcgcg cagctcaagg atgaactgca
     1021 ggcacgcagt gagcagctcc gcagtgggca ggaccaggcc agcgatgcca ccagcctgcg
     1081 gtcaggctgg gaccctgaac ccaaagccca ggctgatata ctggccttcc tgcgtgggca
     1141 ggtggacaag gctgaggtcc acgccggtgt caagctggcc accgaatatg ctgctgtgcc
     1201 ttttgatagc ttcactctgc agaaagtata ccagctggag actggtctga cccgccaccc
     1261 tgaggagaaa ccagtgagga aggacaagcg agatgagcta gtggaagcta tcgaatcagc
     1321 cctggagagt ctaaacagcc ctgtggaaag cagcccacac cagcgccctt acacggctgc
     1381 agacttcata gaagggatct accgaacaga aagggataaa ggcactttgt atgagctgac
     1441 cttcaaaggg gaccataagc atgaattcca acgacttgtc ctatttcgac cttttggccc
     1501 catcatgaaa gtgaagaagg aaaagctcaa catggccaac acacttatca acgttatcgt
     1561 gcccctagcg aggagggtgg acaagttccg gcacttcatg cagaacttca gggagatgtg
     1621 catccaacaa gatgggagag ttcatcttac cgttgtttat tttgggaaag aagaaatgaa
     1681 tgaagtcaaa ggaatacttg aaaacacttc caaggctgcc aattttagaa acttcacctt
     1741 catccagctg aatggagagt tctcccgggg aaagggactg gatgttggag cccgcttctg
     1801 gaagggaagt aatgtcgtgc tctttttctg tgatgtggac atctacttca cctctgagtt
     1861 cctcaacaca tgtaggctga acacacagcc agggaagaag gtattttatc cggttctttt
     1921 cagtcagtat aaccctggca taatctacgg ccatcatgat gctgtccctg ccctagaaca
     1981 gcagctggtc ataaagaagg aaacaggatt ttggagggac tttggattcg gaatgacttg
     2041 tcagtaccgg tcagacttca tcaacatagg tggatttgac ctggacatca aaggctgggg
     2101 cggtgaagat gtgcacctgt accggaaata tctccatagc aacctcatag tgatacgcac
     2161 gcctgtacgg ggacttttcc acctttggca tgagaagcac tgtatggatg aactgacccc
     2221 tgagcagtac aggatgtgca tgcaatcaaa ggctatgaat gaagcatccc acgggcagct
     2281 gggaatgctt gtcttccggc atgaaataga ggctcacctt cgcaaacaga agctcaaagc
     2341 cagcagtaaa aagacatgac ctcccaggta aagattagcc aagacgttta aattttgtgc
     2401 ctttggcagt tactgaagaa gtagatgcaa caaggtatag acttccacaa agggcaacag
     2461 agaatctgac tgatgagtga cagatgaatg aagagtctcg ggtttctgtt ggctctgtgt
     2521 atgctggtga ctctgactgt gtttacagcc aaatgagctc tctggtccct gctccctgaa
     2581 atagtcacaa ccggtttcag aaaaccagaa ggagctgcaa gcccactgac ttctcttctt
     2641 tggattggtt acatcagagg gctttggtac tactaggact accaaaggct cagatggagc
     2701 tctcggacgg agcagaggac ctgtgtgaaa agtggagctc tgacattagt gtcctccacc
     2761 agaccgtgag caaaatcaaa gggacctgga aacaaaccat ccaaactgtc atttccctag
     2821 tattaactga aaaacaaaca aacaaacaaa caaaaaccct aaaaaacaaa aaaaagacaa
     2881 aaacaaaaac aaaaaacaaa gccaacaaca actacaacaa aaacccctct ctttcccatt
     2941 attgtttagt catctctgtt ctaaaaatgc actttttttg cttctgagca ttatgcttat
     3001 ttaattaccc atttccaagc cttagtagga gtacattgta gtacacacat ttttatgatt
     3061 tttttaaaga tttgttttta tgtttttgct gatttgttta cttgagacag tcttgacaca
     3121 gagcccgaga taacttgaaa tcctgatcct cctgtctccg aagcctgagt gctgagatta
     3181 caggtagcta gaagatacgt gcagaggcgt ggagtgagga gctccagttg caggcatgtg
     3241 gagctgatcc aaggacttgc cagtctccga ccacaagaag gctacatgtg gggctgcaga
     3301 gagaaaggta tctacaaact aagactgtcg gaagaggagc aatcaaacac tggaaaaaga
     3361 aaaagatact tttcacaaag aaaggacact aagaagacct tcgtgtattt actagagaat
     3421 ataatttctc ttctggagaa atgggaccac tttcttacct gtttgaataa accaaagtta
     3481 tgaaccaaat gatcactttt caaaacaggg tgctcttctt ggtctctggt ttgcataaag
     3541 aagaaactgc aggaaatata tatatgtata tatatatata tatatatata tatatatata
     3601 tatatatata ttttgaaaga caaatccatt aacccagtga ggtggaagat tctgctccat
     3661 ttccattcac tcctggctag gtggaagcaa cttattttta aaataagcaa tgttacctga
     3721 ttgccaagac gcttctgaag cattttctta caactccaaa tttgtttttt taaaaaaaat
     3781 aaatctgatt aacattgagt ggtttctaca tccatgtgca aattatttat ttattagcca
     3841 gcaccagatg catgagctaa ttacctctcc tgtctctgtg ccttctgttt gcccacagtg
     3901 aactcattgt ttaaatgctt caagaacact caagctgtgt gtttaaaaaa aaaaaaagga
     3961 ttgtattgat ttgtactggt agtttataaa atttaattaa aacacaagac atgaatgaaa
     4021 ggtggcattg cacagctaat aaaatttgtg aatttgattt ctttccataa
//
LOCUS       NM_001436653            5091 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 7 (Slc26a7),
            transcript variant 1, mRNA.
ACCESSION   NM_001436653 XM_063287291
VERSION     NM_001436653.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5091)
  AUTHORS   Kiriya,M., Kawashima,A., Fujiwara,Y., Tanimura,Y., Yoshihara,A.,
            Nakamura,Y., Tanigawa,K., Kondo,T. and Suzuki,K.
  TITLE     Thyroglobulin regulates the expression and localization of the
            novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes
  JOURNAL   Endocr J 69 (10), 1217-1225 (2022)
   PUBMED   35644541
  REMARK    GeneRIF: Thyroglobulin regulates the expression and localization of
            the novel iodide transporter solute carrier family 26 member 7
            (SLC26A7) in thyrocytes.
REFERENCE   2  (bases 1 to 5091)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5091)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            acid challenge represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   4  (bases 1 to 5091)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   5  (bases 1 to 5091)
  AUTHORS   Kosiek,O., Busque,S.M., Foller,M., Shcheynikov,N., Kirchhoff,P.,
            Bleich,M., Muallem,S. and Geibel,J.P.
  TITLE     SLC26A7 can function as a chloride-loading mechanism in parietal
            cells
  JOURNAL   Pflugers Arch 454 (6), 989-998 (2007)
   PUBMED   17404755
  REMARK    GeneRIF: SLC26A7 is a Cl(-) uptake system under histamine
            stimulation
REFERENCE   6  (bases 1 to 5091)
  AUTHORS   Petrovic,S., Amlal,H., Sun,X., Karet,F., Barone,S. and Soleimani,M.
  TITLE     Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7
            in kidney medullary collecting ducts of Brattleboro rats
  JOURNAL   Am J Physiol Renal Physiol 290 (5), F1194-F1201 (2006)
   PUBMED   16352747
  REMARK    GeneRIF: vasopressin increases the expression of SLC26A7 protein
            through posttranscriptional mechanisms in the outer medullary
            collecting duct
REFERENCE   7  (bases 1 to 5091)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
REFERENCE   8  (bases 1 to 5091)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
REFERENCE   9  (bases 1 to 5091)
  AUTHORS   Lohi,H., Kujala,M., Makela,S., Lehtonen,E., Kestila,M.,
            Saarialho-Kere,U., Markovich,D. and Kere,J.
  TITLE     Functional characterization of three novel tissue-specific anion
            exchangers SLC26A7, -A8, and -A9
  JOURNAL   J Biol Chem 277 (16), 14246-14254 (2002)
   PUBMED   11834742
REFERENCE   10 (bases 1 to 5091)
  AUTHORS   Mocellin,R. and Buhlmeyer,K.
  TITLE     Late banding operation in children with ventricular septal defect
            and pulmonary arterial hypertension
  JOURNAL   Eur J Cardiol 3 (3), 205-211 (1975)
   PUBMED   1183472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063287291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20671.1,
                                           SRR26643287.12744.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000005.1  32818836-32818928   c
            94-314              JAXUCZ010000005.1  32818355-32818575   c
            315-425             JAXUCZ010000005.1  32786927-32787037   c
            426-598             JAXUCZ010000005.1  32780136-32780308   c
            599-763             JAXUCZ010000005.1  32757312-32757476   c
            764-916             JAXUCZ010000005.1  32743404-32743556   c
            917-999             JAXUCZ010000005.1  32734765-32734847   c
            1000-1147           JAXUCZ010000005.1  32732596-32732743   c
            1148-1261           JAXUCZ010000005.1  32730466-32730579   c
            1262-1339           JAXUCZ010000005.1  32721568-32721645   c
            1340-1435           JAXUCZ010000005.1  32720536-32720631   c
            1436-1542           JAXUCZ010000005.1  32712705-32712811   c
            1543-1609           JAXUCZ010000005.1  32704950-32705016   c
            1610-1747           JAXUCZ010000005.1  32701574-32701711   c
            1748-1796           JAXUCZ010000005.1  32698486-32698534   c
            1797-1897           JAXUCZ010000005.1  32689483-32689583   c
            1898-1952           JAXUCZ010000005.1  32685795-32685849   c
            1953-2056           JAXUCZ010000005.1  32685608-32685711   c
            2057-5091           JAXUCZ010000005.1  32681653-32684687   c
FEATURES             Location/Qualifiers
     source          1..5091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5091
                     /gene="Slc26a7"
                     /note="solute carrier family 26 member 7"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
     exon            1..93
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            94..314
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    116..118
                     /gene="Slc26a7"
                     /note="upstream in-frame stop codon"
     CDS             122..2092
                     /gene="Slc26a7"
                     /note="isoform a is encoded by transcript variant 1; anion
                     exchange transporter; solute carrier family 26 (anion
                     exchanger), member 7"
                     /codon_start=1
                     /product="anion exchange transporter isoform a"
                     /protein_id="NP_001423582.1"
                     /db_xref="GeneID:297910"
                     /db_xref="RGD:1310846"
                     /translation="MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLK
                     ENLLPDTVSGVLLAVQQVTQGLSFAILSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG
                     TFALTSLISANAVERLVPQSNRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQL
                     VMFVLQLGNATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAY
                     VFENIKSVQLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCT
                     NMENTYGLEVVGRIPKGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKF
                     KYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLI
                     VIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTIC
                     FAANVGLLFGVVCTIAIVLGRFPRAKTLSITDMKEMELKVKTETYDENSQQIKIISIN
                     NPLVFLNAKKFSADLMKIILKETDGSQALDDVSKCEQNTLLSPLPNGSCTEEASQPCP
                     SEKYSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLD
                     TEKPIFFDSVATAISVIQSNKNLSKDTDHSEV"
     misc_feature    218..2032
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    218..2032
                     /gene="Slc26a7"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     exon            315..425
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            426..598
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            599..763
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            764..916
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            917..999
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1147
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1261
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1339
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1435
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1542
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1609
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1747
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1796
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1897
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1952
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2056
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..5091
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaccatct caccgccgaa cccattcctt ttccaagatc agaaaagtag tacatgaaca
       61 gggacccatt tcttattgag ataagaactc aagttgacta ctacaggagg gaatctgaga
      121 aatgacgggg gcaaagagga aaaagagaag cgtgctgtgg ggcaagatgc acacccccca
      181 ccgagaagac attaaacagt ggtgtaagag gcgcctacct atcttggaat gggcaccgca
      241 gtacaatctg aaggaaaacc tgcttccaga caccgtgtct ggcgtactgt tggcagttca
      301 acaggtgaca caagggctgt ccttcgctat tctttcatct gtacacccag tttttggttt
      361 atacggatct ctgtttcctg ccatcattta tgcgatattt ggaatgggac gccatgttgc
      421 cacaggcacc tttgccttga cgtccttgat atcagccaat gctgtggaac ggctggtccc
      481 tcagagcaat agaaacctca ccacacagag caactcaagc gtgctgggct tatcggagtt
      541 tgagctgcag agaatcgggg ttgcagcagc cgtttcattc ttgggcggag tgattcagct
      601 ggtcatgttt gtgctgcagc taggcaatgc cacattcctg cttacggagc cagtgatcag
      661 tgccatgacc accggcgctg ccacccatgt tgtgacgtca caagtcaagt atctcttggg
      721 aataaaaatg ccatatatat ctggaccact gggattcttt tatatctatg cgtatgtttt
      781 tgagaacatc aagtctgtcc agctggaagc actgctcttg tccttgctga gcattgttgt
      841 ccttgtcctc gttaaagagc tgaacgagca gtttaagaga aagattaaag ttgttcttcc
      901 tgtcgactta gttttgatca ttgctgcctc atttgcttgc tattgtacca acatggaaaa
      961 cacatacgga ttagaagtag ttgggcgcat tccaaaaggg atccctccgc cccgtgctcc
     1021 cccaatgaac atcctctccg cagtgctcac ggaagctttc ggagttgcac ttgtaggcta
     1081 cgtggcctcg ctggctctcg cacaaggatc tgccaagaag ttcaaatatt cagttgatga
     1141 caaccaggaa tttttggccc atggcctcag caacgtgatt ccttcatttc tcttctgcat
     1201 cccaagcgcc gccgccatgg gaaggacagc tggtctgtac agcacggggg caaagacaca
     1261 ggtggcttgt ctaatatctt gcattttcgt ccttatagtc atctatgcaa taggaccctt
     1321 gctgtactgg ctgcccatgt gcgttcttgc aagtattatt gttgtgggac tgaaaggaat
     1381 gttaatacag ttccgggatt taaaaaaata ctggaatgtg gataaaatcg attggggcat
     1441 atggatcagc acttacattt ttacaatatg cttcgctgcc aacgtgggac tgctctttgg
     1501 tgttgtctgc accatagcta tcgtgttagg gcgtttccca agggcaaaga ctttaagcat
     1561 aacagacatg aaagaaatgg aattgaaggt gaagacagaa acgtatgatg aaaactcgca
     1621 acagataaaa atcatctcaa taaacaaccc acttgttttc ctgaatgcaa agaaatttag
     1681 tgctgatctt atgaaaataa tcctaaagga aactgacggc agccaagcac ttgatgatgt
     1741 cagcaagtgt gaacagaaca ccttgctcag tcccctgccc aacgggagct gcactgaaga
     1801 agcctcccag ccctgcccca gtgagaagta ttctttggtc ctgaattgca gtggcttgac
     1861 ctttttcgac tacacaggag tctccacact tgttgagctc taccttgatt gcaagagcag
     1921 gagtgtggat gtgttcttag ccaactgtac agcatccttg ataaaagcga tgacatacta
     1981 tggagaccta gacactgaaa aaccaatttt ttttgactcg gtagccactg caataagtgt
     2041 catccaatca aataagaatt tgagcaagga cactgaccac agtgaagtct gaggtccacg
     2101 cattgaaatg cacatctcat ctttagcacc tgccccaaag aggccagata ctggcatttt
     2161 gcactcattt tggtgtatat actgtatatc tcttaattag aatgatgtga gttggcaact
     2221 ggatagccac tggccaagac ttgctgacat cctatttttt ctaatttttc ttaataaaca
     2281 gattcattag ttatttcata taggcatcaa tatgcatgta gctttagttt aatgaacagt
     2341 aaacatgctt ttatttccag ttataagagt attttgtatg gtttcatttt tgttgtaagc
     2401 taacaaatgg agaaatattt ttatcagaaa tggtttggat tatttataaa ccattcataa
     2461 aaaaattaag atcatctagt acataaaaaa gtattaacaa atgtgccatt tctccatagt
     2521 ttttatccca aaattatttg aacatcagtt agataaagta tcacttttat acagggaaaa
     2581 tgaaatccat agatataaaa caagtgagaa agagacaaat tagaagttat taatgtcaat
     2641 gcccatcaac acactcactc tgacaatatt catatattca attatgagtt catatttgga
     2701 agaaaactaa tgttttagca aaactaagtt cttgatgttt atctgctgaa ttgtggatac
     2761 tggagaccat ttgtgtgttt aatcagataa ctctgacttc tgcattgcaa cacataagat
     2821 attctgcttt caaacttctt tcttgcaatc agagaatatg agaatttgat atgtattttt
     2881 tcaaaaatat gcatttttca atgataaaat atcataagta gaatgctttt gtgcttttgg
     2941 atacaagatt aacccttaga aattttgaat tttctatttg agatataaaa agtcaacaaa
     3001 atataatatg ttattgatct ataccaagat agatagattg aagatagaac gacagacaga
     3061 cagacagaag acaggtagac aacagacaga tgacagacag atctccaagg tatgttttcc
     3121 attttctttt gttagagatg agcttgaatg tgattatacg taaatttgct aatacaatag
     3181 gataatttat aacactaatg gccagatata agtgtaaaca tttttcatac ttgtatattt
     3241 tatttttatc tatatacaag aatgaaattt cacaattttt taaacaaatt gtcttatata
     3301 tgaagccaca gattaaatta tgatttatcc ttaatagcat ctaaaacatt ctacaaagtt
     3361 agtaacgctg tcagaaaaaa aaaaaacaaa acacaaaaaa aaaaaaaaca gcaaagggag
     3421 tttgaaaagc aagttaaaaa ttggccttct ggtgtggttc ttatgggcat ctgtaagagc
     3481 aaattctaac tcctgtccaa atgacagagt ggaatagtcc ttcgccagtg caaggtaaac
     3541 atttacacaa tccactgttt taacacctca ctctttggca ggatgaaata ataagtgaaa
     3601 actaaaaata gcgctctaaa ttttcatggt cattttcaat ttttactgaa acaaattcaa
     3661 aagtcttgtt cccccaaatt gccccaattt cttcatcact tattggggta gtaccaagta
     3721 aggtgaccag tattgctcat cagataggtt tctaagggaa gtctgaggga gaattagaaa
     3781 ggagttttat tctgcgtcat ccacttccct tactctatac gtgcagagtg gtggactcta
     3841 ccttgtaatc aggagtcatg cgaagccaag aaaagaaata gattatggtg catagaaagt
     3901 gatattttgc tatacaaatt tgaccttaat taaattcatg agttgtaggc atttttaatt
     3961 tgttgtagat gatgggcctt gggtgacatt aaagtcatta tagctatttg ttggatagtt
     4021 tttctgtttc gttgtgaatg ctcagacagt attgtctgag aaactgcatc tgagtgcatt
     4081 taagtataag cttaatgcat aaaaagtcaa ccccatcaat ttcagtatca aacattgtta
     4141 cagccaaaac aagaaagaca agaccacaca ctgtataaag tccactgctc tatagtttat
     4201 gccaagacca caatcttttt aacccaaaga aagtctctta attaaggtcc aaggctccaa
     4261 gaactgcaca taagttttag acatacaagt gtttatttca aagcagactc agagagcaga
     4321 gaagctacaa catggctcta gtgttgtaat attttctatc agcacactga cctattctga
     4381 gggggccatg ttaattttat atgataaact ccttccgtag tacttattat agtaaaataa
     4441 catagaaaac tgacctatac gagtgttaag aacctaatat ggcagatatg aaatatgtaa
     4501 ccaggaaaaa ctgttaacat taaacatcac atttatgcaa attaaatgcc cttaaaattt
     4561 tgccattcgt ctttcatttt taaaggttat ttgccctcaa ttatgtaatt tcagtgttat
     4621 aaagtttagc ttaaactact ttgcaataat ttatttgaca gatctccgtt ctataaacca
     4681 tgcaatgtaa tgaggccaga gatctttctt ttttaatgaa aacattaaca tgttaatatc
     4741 ccacatgaat gatgcttgac attcaacgat tgtcgaaata tgttggtatg ttgctgaaca
     4801 tacacacacc tctgaaatgc cagttctgcg ttctgtgggc tgatgatctg actcatcgtg
     4861 tgacatatgc tttctggcag tgagttcatt gccagagttt aaacagggag ttacggtgct
     4921 catggcgctt tcagaaccca aagatttgtg gtttggaatc atgtagtcta gtatgctgca
     4981 cttattttta tatttttaat gcacttaatt attgttttta caattatttg tactaactca
     5041 gcatgtaaca accaatttac atggaaataa attgaaatat gataactaca a
//
LOCUS       NM_001436621            4245 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus junctophilin 1 (Jph1), transcript variant 1,
            mRNA.
ACCESSION   NM_001436621 XM_006237720
VERSION     NM_001436621.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Rossi,D., Scarcella,A.M., Liguori,E., Lorenzini,S., Pierantozzi,E.,
            Kutchukian,C., Jacquemond,V., Messa,M., De Camilli,P. and
            Sorrentino,V.
  TITLE     Molecular determinants of homo- and heteromeric interactions of
            Junctophilin-1 at triads in adult skeletal muscle fibers
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15716-15724 (2019)
   PUBMED   31315980
  REMARK    GeneRIF: Molecular determinants of homo- and heteromeric
            interactions of Junctophilin-1 at triads in adult skeletal muscle
            fibers.
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Murphy,R.M., Dutka,T.L., Horvath,D., Bell,J.R., Delbridge,L.M. and
            Lamb,G.D.
  TITLE     Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in
            skeletal and cardiac muscle
  JOURNAL   J Physiol 591 (3), 719-729 (2013)
   PUBMED   23148318
  REMARK    GeneRIF: This study demonstrates that both JP1 and JP2 in skeletal
            muscle undergo Ca2+-dependent proteolysis by endogenous proteases
            when the intracellular Ca2+ is raised within the physiological
            range for a sustained period
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Liang,X.G., Wu,B.W., Zhang,W.C., Zhou,L.M., Zhu,D.Y. and Lou,Y.J.
  TITLE     [Expression of Junctophilin 1 during cardiogenesis of mouse
            embryonic stem cells and rat embryos]
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 41 (4), 359-365 (2012)
   PUBMED   22927069
  REMARK    GeneRIF: JP1 gene is expressed during the whole process of
            cardiogenesis, while JP1 protein only appears during the early
            stage.
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Komazaki,S., Nishi,M. and Takeshima,H.
  TITLE     Abnormal junctional membrane structures in cardiac myocytes
            expressing ectopic junctophilin type 1
  JOURNAL   FEBS Lett 542 (1-3), 69-73 (2003)
   PUBMED   12729900
REFERENCE   5  (bases 1 to 4245)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   6  (bases 1 to 4245)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237720.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20316.1,
                                           SRR26643296.14500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               JAXUCZ010000005.1  6813556-6814175
            621-1380            JAXUCZ010000005.1  6819668-6820427
            1381-1499           JAXUCZ010000005.1  6878981-6879099
            1500-2143           JAXUCZ010000005.1  6896746-6897389
            2144-2239           JAXUCZ010000005.1  6903709-6903804
            2240-4245           JAXUCZ010000005.1  6904236-6906241
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4245
                     /gene="Jph1"
                     /note="junctophilin 1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
     exon            1..620
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Jph1"
                     /note="upstream in-frame stop codon"
     CDS             242..2224
                     /gene="Jph1"
                     /codon_start=1
                     /product="junctophilin-1"
                     /protein_id="NP_001423550.1"
                     /db_xref="GeneID:297748"
                     /db_xref="RGD:1308789"
                     /translation="MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSH
                     GFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCT
                     PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLR
                     TSLASLRSEQSNGSVLHEAAAAAADNPAGTRGGFVLNFHADTELGKKKSGLFRRGSLL
                     GSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDAT
                     TTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN
                     ILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAAD
                     QAAVAARQECDIARAVARELSPDFYQPGPDYIKQRFQEGVDIKENPEEKVPEKPPSPK
                     ESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSGARLSHDKRNTAEEQVV
                     AIVNKPLMSKAPSKELGATVSKYSGRHYVPNPSNGELHSQYHGYYVKLNTPQHPPEDR
                     EDDSGVGQSSSALVPRPSPNKWSPPKSVTKPVAKESKTEPKAKKSELAIPKNTASNDT
                     CPPLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <248..1240
                     /gene="Jph1"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     misc_feature    <1469..2155
                     /gene="Jph1"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; Region: PspC_subgroup_2; NF033839"
                     /db_xref="CDD:468202"
     exon            621..1380
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1499
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2143
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..4245
                     /gene="Jph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctctctc gcggcgctgg cccgggcggc ggcggaggag ggagagagga ggtggtggcg
       61 accgcgagag aggaggggag gacgggggca gcgtcggact ggagccgatc ggcggtgcga
      121 gctgcccggg gcgcagtcgt gagctcgccc gctgggtccc cacccacgag ctacaccctg
      181 cagtgcccag ctctgcccgc gtacgtgccc ccgcggggag cgcgcagggg ctgtcccccg
      241 aatgacgggc ggaaggttcg acttcgacga tggcggcacc tactgcggcg gctgggagga
      301 gggcaaggcg cacgggcatg gcatctgcac ggggcccaag ggccagggcg agtactctgg
      361 ctcctggtcg cacggcttcg aggtggttgg aggctacacc tggcccagcg gcaacaccta
      421 ccagggctat tgggcgcagg gcaagcggca tgggctgggg gtggagacga agggcaagtg
      481 gatgtaccgg ggggagtggt cacatggttt caaggggcgc tacggggtcc gacagagcct
      541 gtgcaccccc gcccgctacg aggggacctg gagtaacggg ctgcaggacg ggtacggcgt
      601 ggagacctac ggggatggag gtacctacca gggccagtgg gctggaggca tgcggcatgg
      661 ctacggtgta cgccagagtg tgccctatgg catggccacg gtgatccgct ccccgctgcg
      721 cacctccctg gcctcactgc gcagtgagca gagcaatggc agcgtgctgc atgaagctgc
      781 agccgcagct gcagataacc cggccggcac aagaggtggc ttcgtgctca acttccatgc
      841 ggacacagag ctgggcaaga agaagagtgg cctcttccgt cggggctctc ttctcggcag
      901 catgaaactc cgcaagtccg aatccaagtc ttccatctcc agcaagcgca gctcggtccg
      961 cagtgatgca gccatgagca gaatcagttc tagcgatgcc aactccacca tcagcttcgg
     1021 tgacgtggac tgtgactttt gccctgtgga agatcatgtg gatgccacca ccacggaaac
     1081 ctacatgggc gagtggaaaa acgataagcg caatggcttc ggcatcagcg aacgctccaa
     1141 cggcatgaag tacgaaggcg agtgggccaa taacaagagg catgggtacg gctgcactgt
     1201 gtttcccgac ggctctaagg aagaggggaa atacaaaaat aatatcctgg tccgtggaat
     1261 aaggaagcag cttataccaa taagaaatac aaaaactagg gagaaggtgg atagagccat
     1321 tgaaggtgca caaagggcag cggccatggc cagaaccaaa gtggaaatag caaactcaag
     1381 gactgcacat gccagagcaa aagctgatgc tgctgatcaa gctgcagtgg ctgctcgcca
     1441 ggagtgcgac attgcgagag ctgtggccag agagctgtca cctgatttct accaaccagg
     1501 tcctgattat atcaaacaaa gatttcaaga gggggtagat attaaagaaa atccagaaga
     1561 aaaggtccca gaaaagcctc catcaccaaa ggaatcgcct catttttatc gcaaaggtac
     1621 aacacccccc aggtctcccg aggcaagtcc caaacagagc cactctcccc agccttcctc
     1681 cccaaagtcc atgaagaaac agaaccccag ctcaggggca agactcagtc acgataaaag
     1741 gaacacggct gaggaacaag tggtagccat tgtcaataag cccttgatgt caaaggctcc
     1801 ttcaaaggaa ctgggagcaa ccgtgtccaa gtactctggc cgccactatg tccccaaccc
     1861 cagcaatggg gagctgcact ctcagtatca cggctactat gttaaactga acacgcccca
     1921 gcatcctcca gaagacaggg aggatgacag cggagttggc cagtcttcct cagcattggt
     1981 acctagaccg tcacctaaca agtggagtcc ccctaaatct gtgacaaaac cagttgccaa
     2041 agaaagcaaa actgagccaa aagcaaagaa gtctgaactt gctataccaa agaatacagc
     2101 aagcaatgat acctgccctc ctttagaaaa agaagccaat tccggcccta attccatcat
     2161 gattgtcctg gtcatgttgt tgaatattgg gttggccatt ctttttgttc actttctcac
     2221 ttgattggaa ttaggaaagc cccatccggc gaagttcttg gcgttggcta ctccatctgt
     2281 cctagcagag tgtgactaaa ctggaaatgt atggacctgc aatttttttt ttgatggaag
     2341 tcaacagctg ccttactatt ttaccatctg acgtttttag tagggagctg ggttgagaag
     2401 actgccagag gaatgcagtc tgaggattgt gttgcagtgg gcatggcgcc aacattcact
     2461 cctatctcat tagaagaagt aggtagcagc atcactcaga ggtcttctgc tgtgacctac
     2521 tgctttaaca tctcctggaa tgttctgaaa gggaatattt catttgcttg tgcacaactc
     2581 tgctcatttt tgctgtttat ttaaatatga ccgcatagtc atcttccact cgcaatcctg
     2641 gctggatgag aagacacagg ttgcatctca aggaaaagca acaacaaaag actagttaaa
     2701 aaatatatag tgtttatttt aatagcaata cattgttttc atgttgttta ttctttttaa
     2761 atcaataaaa gatttattta tctttaaaat atagtgatct gaaggtatta taccttccaa
     2821 agaaataatt taatattaaa tatttttaac accattgagg tgaattgttg acgcactcag
     2881 gtgctacatt ttacaagctg aaagactaca tattaccaag aagtgtagtc aaaatgttgc
     2941 atggatttca gtaatcagtg gttaaaggtt cggtttcatt gctgacgtat gttacaacca
     3001 aataaaatct tgtcagtggc tctgttaatt cccatgaaag ttaagcaaga tctattaata
     3061 gctactcttc tctttctcta ccccaccccc agctcgaatt ttggttgaat gcattcaggt
     3121 agacagtaaa gttttgttaa gtcactgccc cttctctgcc ttcagtgttt ttcaaagttg
     3181 ttttgtaatt ctattttaaa ttttaaagac ttagatggtt ttattttaaa tatttgtctt
     3241 ttgctgtcct gtatcattct gatgttgatt ttttttctat tatataattt actgagaagc
     3301 atgcttaact agggaaacta catgatcttt ataaaaaaat aattatttaa aaagaaatca
     3361 gtgtaggaaa gatatgtctg aatctcttaa aggcattgcc ttgtggaggg ggaagtcttc
     3421 ctaactttta tccaggatat catggtgtca gccgagtctc ttacttaggg gcctttgcag
     3481 agacagtgtg tgtcactccc ctgatagcac aggagaggac cacatgcttc atcacctaca
     3541 gggtagtaaa ccagtggtgg tctctccaga agtgcaatat attgagactc ttgggtatga
     3601 ccaatatgga ttaaagaaga aggcagaaag agagcaaatg aaaataaaat tacaacttgt
     3661 atatttattt tttacatttt gctttgactt tagggagtcc atttttactc aagaacaaac
     3721 taagtctgtc tgtcgtctgc atagtctccc tgcctgttcc tacccttgaa gctccttatg
     3781 ctgggaaggc tgtttgtttg tttttttaag aaatagaata tttaatctga ataagtgttt
     3841 atttaaatgt gtaatgcttt gaaaataatg ggcaacagag aactaaagga tgtttataaa
     3901 gtgagcttgt tggctccatt tataaatata tacgatttat aagctttttt aaaacaaagc
     3961 tcaaattgtg ggtatttttc taaaatgtgc acagctgtat tttccatgaa ggatctttct
     4021 aatgggttgt tatactgtac tctacatttt ggacagcaca tgaagtctgc caatgtactt
     4081 aataaaacat gactttgttt atttaaagtt tcttgctgtg aaaaacccta ccagtgggtt
     4141 ccttaattta taatccttaa aaccaaaatg tataatgtac agtttccaca actgtaactg
     4201 ccctaataaa aatgttggtt attaataaag ttcgagatgt ctttc
//
LOCUS       NM_001191108            4127 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus interactor of little elongation complex ELL
            subunit 2 (Ice2), mRNA.
ACCESSION   NM_001191108 XM_001075498 XM_006243402
VERSION     NM_001191108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4127)
  AUTHORS   Hu,D., Smith,E.R., Garruss,A.S., Mohaghegh,N., Varberg,J.M.,
            Lin,C., Jackson,J., Gao,X., Saraf,A., Florens,L., Washburn,M.P.,
            Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex functions at initiation and
            elongation phases of snRNA gene transcription
  JOURNAL   Mol Cell 51 (4), 493-505 (2013)
   PUBMED   23932780
REFERENCE   2  (bases 1 to 4127)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   3  (bases 1 to 4127)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   4  (bases 1 to 4127)
  AUTHORS   Sugiura,N., Dadashev,V. and Corriveau,R.A.
  TITLE     NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is
            expressed during development
  JOURNAL   Eur J Biochem 271 (23-24), 4629-4637 (2004)
   PUBMED   15606750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 14, 2025 this sequence version replaced
            XM_006243402.5, NM_001191108.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2785828.1,
                                           SRR26360172.1461442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000008.1  78924434-78924557
            125-266             JAXUCZ010000008.1  78925458-78925599
            267-371             JAXUCZ010000008.1  78926729-78926833
            372-621             JAXUCZ010000008.1  78937486-78937735
            622-741             JAXUCZ010000008.1  78939132-78939251
            742-879             JAXUCZ010000008.1  78941077-78941214
            880-996             JAXUCZ010000008.1  78941741-78941857
            997-1156            JAXUCZ010000008.1  78942065-78942224
            1157-1338           JAXUCZ010000008.1  78943368-78943549
            1339-2389           JAXUCZ010000008.1  78948157-78949207
            2390-2565           JAXUCZ010000008.1  78949789-78949964
            2566-2695           JAXUCZ010000008.1  78954353-78954482
            2696-2780           JAXUCZ010000008.1  78958365-78958449
            2781-2831           JAXUCZ010000008.1  78959554-78959604
            2832-3090           JAXUCZ010000008.1  78961076-78961334
            3091-4127           JAXUCZ010000008.1  78964963-78965999
FEATURES             Location/Qualifiers
     source          1..4127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4127
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="interactor of little elongation complex ELL subunit
                     2"
                     /db_xref="GeneID:691379"
                     /db_xref="RGD:1585038"
     exon            1..124
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..266
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="upstream in-frame stop codon"
     CDS             226..3219
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="NMDA receptor-regulated gene 2; NMDA
                     receptor-regulated protein 2; NMDA receptor regulated 2;
                     interactor of little elongator complex ELL subunit 2"
                     /codon_start=1
                     /product="little elongation complex subunit 2"
                     /protein_id="NP_001178037.1"
                     /db_xref="GeneID:691379"
                     /db_xref="RGD:1585038"
                     /translation="MSSGITMSEPRLNWDVTPKNGLKVFFSPENYKDHSMAPSLKELY
                     ILSNRRIGENVSVSANSVENEPAVSSATQAKEKVGMILLPKPRVPYPRFSRFSQREQR
                     TFVDLLVKYAKIPSSSKTVGTNTNEFLQYLDMKKHVNEEVNEFLKFLQNSAKKCAQDY
                     NMLSDEARLFTEQILRACIEQVKKYPEFYTLHEVTSLMGFFPFKIEMGLKLEKTLLVL
                     GSAKFVKTAFPSMPVKLQLSKEDMSSIENPQQQAEAMHCDISKDPNAEKLVSRYHPQI
                     ALTSQALFTLLNNHGPSYKEQWEIPVCVQMIAVEGSKPVKVIYINSPLPRKQMTMRER
                     NQIFHEVPLKHIFSKTTSVPVSAVFMDKPEEYTSEVDISTEASECRKIETLENLDLDF
                     DGDVTELETFGVTTTSPSRSPSSESDSSAPIMTDVHTAPKVTAIPVAPAAPVTPAAPV
                     APVVAPVAPVVAPVAPAAPVTPVTPEASAIPNITDDSRSLCQILMKQLQKEKQLFSGV
                     ESGPEACKNKDDQGLEPCAEEGPSANAKSLTQDSEVHRTEEISNESDVGALCTSDERQ
                     SVQKNADNPNETATASETADTEKGIPCGSDTDEDCLIIDTESKSNSDGRTAGLGSSPN
                     SSAQASVENQTTTTVSEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPVSRTIPELP
                     LTNSEESKQPSASEQPSATLDASTWPKSSWPSAFQKPKGRLPYELQDYVEDTSEYVAP
                     QEGNFVYKLFSLQDLLLLVRCSVQRVETRPRSKKRKKIRRQFPVYVLPKVEYQGCYGV
                     EALTESELCRFWTESLLHSNCSFYVGHIDAFTSKLFMLEEITSEELKEKLAALKISSL
                     FNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKAHCDLPGVP
                     SSLSVPWVPLDPSYLLPYHIHHGRIPCTFPPKSLRPAAQPKVGATRMPTRNHRNPVSR
                     ETKSSCLPVQQVENEGVAQNKRKIM"
     misc_feature    2428..3060
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="NMDA receptor-regulated gene protein 2 C-terminus;
                     Region: NARG2_C; pfam10505"
                     /db_xref="CDD:463121"
     misc_feature    2428..3060
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="NMDA receptor-regulated gene protein 2 C-terminus;
                     Region: NARG2_C; pfam10505"
                     /db_xref="CDD:463121"
     exon            267..371
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..621
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..741
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..879
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..996
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1156
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1338
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..2389
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2565
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2695
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2780
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2831
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3090
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..4127
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccgtgc gggcgccctc ggggctttta aatggggcct tcctaggcgg gaagcagcga
       61 gttcagcaaa gcgtgtgtgg aagtgtcggc ttttctcggg gccggagccg cttgggaccc
      121 tgagttgaat gtagattcta ggaaggatcc aatcctcact ctctggaaac cttcacttcc
      181 aggctgaagt aattgtgggc tagagtgaag gagagttcta ggaagatgag ctctggcata
      241 accatgagtg aaccaaggct gaactgggat gttacaccca aaaatggcct taaagtcttt
      301 ttctctccag aaaattataa agatcattcc atggctccaa gtttaaaaga actctatatt
      361 ttgtccaaca gacgtatagg agaaaatgtg agtgtctcag caaattctgt agaaaatgag
      421 cctgcagtta gttcagcaac tcaagcaaag gaaaaagttg ggatgattct ccttcccaaa
      481 ccaagagttc cttatcctcg tttctctcgg ttctcacaga gagagcagag gacttttgtg
      541 gatttgttgg ttaaatatgc aaagatcccc tcaagttcca agactgttgg aacaaataca
      601 aatgaatttc tacagtatct ggatatgaaa aaacatgtga atgaagaagt taatgaattc
      661 ctaaagtttt tacagaattc tgcaaagaaa tgtgcacagg attataacat gctctctgat
      721 gaggcccgtc tcttcacgga gcaaatccta agagcttgca ttgagcaagt gaaaaagtac
      781 ccagaatttt atacgcttca tgaagttacc agcctaatgg gattcttccc cttcaaaata
      841 gagatgggac tgaagttaga aaagactctt cttgttttgg gcagtgcaaa gtttgtaaaa
      901 acagcatttc cctcgatgcc tgtgaaactg cagctctcca aagaggacat gtcttccatt
      961 gagaacccac agcaacaagc cgaagcgatg cactgcgata ttagtaaaga cccgaatgca
     1021 gagaaacttg tttcaagata ccatcctcag atcgctctga ctagccaagc attattcacc
     1081 ttgctcaata accatggacc aagctacaag gagcagtggg agatcccagt gtgtgttcag
     1141 atgatagctg tggaaggttc caaaccagtt aaagtaattt atatcaattc gccacttccc
     1201 cgaaagcaaa tgacaatgag agaaagaaat caaatcttcc atgaagttcc attaaaacat
     1261 atattctcaa aaaccacatc tgttccagtc tctgctgtct ttatggacaa acctgaagag
     1321 tacacctctg aggtggatat atccactgaa gctagtgagt gccgaaaaat tgagactctg
     1381 gaaaatttgg atctggactt tgatggtgat gtcacagaac ttgaaacctt tggagtaact
     1441 actactagtc catccaggtc accaagttca gaaagtgact cctctgcacc catcatgaca
     1501 gatgtccaca cagcccccaa agtaacagct atacctgtgg caccagctgc tcctgtgaca
     1561 ccagctgctc ctgtggcacc agttgttgct cctgtggcac cagttgttgc tcctgtggca
     1621 ccagctgctc ctgtaacacc agttacacct gaggcatcag ctataccaaa cattactgat
     1681 gattctagaa gtttatgtca gattctgatg aaacagttac agaaggagaa acagctattc
     1741 tctggtgtgg aaagtggtcc tgaagcatgc aaaaataaag atgatcaagg gcttgaacca
     1801 tgtgctgaag agggtcccag tgccaatgca aagtctttaa cacaagacag tgaagtccac
     1861 agaactgagg aaatttctaa tgagagtgat gtaggtgcgc tgtgtaccag tgatgaaaga
     1921 caaagtgttc agaagaacgc agacaatccc aacgaaacag ccactgcatc agaaacagct
     1981 gacactgaga aagggatacc ttgtggcagt gatacagatg aggactgctt aatcattgat
     2041 acagagagta aaagtaatag tgatggaagg acagctggtt tgggttctag tccaaattct
     2101 tcagcacagg cttctgtgga aaaccagacc actactactg tttctgagga atcttgtgtt
     2161 ttaaagaaac ctatcaaaag agtctataaa aaatttgatc cagttggaga aattctaaaa
     2221 atgcaggatg agcttttaaa accagtttcc aggacaatac ctgagttgcc cttgactaat
     2281 tcagaagaat ctaaacagcc atctgcttct gagcaaccct ctgctacttt ggacgcctcc
     2341 acctggccaa aatccagttg gccctctgca tttcagaagc ctaaaggacg attgccatat
     2401 gaacttcaag actatgtgga agacacatca gaatatgtag ctcctcaaga aggaaacttt
     2461 gtctataagt tgttcagcct acaagacctg ttgttacttg tgcggtgcag tgtccagagg
     2521 gtagagacaa gaccacgctc caaaaaacgg aagaagatca gaagacaatt tccagtttac
     2581 gtgctaccaa aagtagagta tcaaggttgt tatggagttg aagctctgac tgaaagcgag
     2641 ctctgtcgct tctggactga aagtttattg cattccaact gctcgtttta tgttggtcat
     2701 attgatgcgt ttacttcaaa gcttttcatg ctagaagaaa tcacctcaga agaattaaaa
     2761 gaaaaacttg cagcactcaa gatttcaagt ttatttaaca ttctccagca cattttaaag
     2821 aaattatgta gcttgcagga agggtcctac ttgctgtctc acgcagcaga agattcttca
     2881 ctcctgatct acaagacctc agatggaaaa gttactagaa cagcgtataa tttgcataag
     2941 gcacattgtg accttcctgg tgtaccctcc agtctctcgg ttccttgggt cccattagat
     3001 cccagttacc tgttaccata tcacatccat catggacgaa taccttgtac ttttccacct
     3061 aaatcactgc gccctgcagc acaaccaaag gttggtgcga caagaatgcc tacccggaac
     3121 cacaggaatc cagtttccag ggaaaccaaa agcagttgcc tgcctgttca gcaagttgaa
     3181 aatgaaggag tggctcagaa taaaaggaaa ataatgtaag ggctggacca ccgaaagtaa
     3241 agtttcagaa aactcagtta taacagtgtt taatgttgaa ctttaaggga aacatgccca
     3301 aaagaccggc tagcaagaat gtttctcctc gctatcctgg agttcttaca aagtgccttg
     3361 gaaacctact gactgcggga agagcagtga cagcagaagt tagtcactcc tcagctctgg
     3421 tgcatggaga atctagaatg ctccattggc aaggtagcaa actgaataag aaaaatattt
     3481 ttatagcatt cttttctaaa atcataggta ggaaaatcac ttgctatttt aggaacagtc
     3541 atatattata ttatcaattt gattatattg ctactcaaat gagactggcc taaacagtta
     3601 aatatcgcca atgttagaga cagctgtgtg cattgcttat gacccatttt tgtcagtagt
     3661 aaaactgctg ttgatgtgtt tgaaaacctg ttgaaattcc tttgtggaca ccagaaatga
     3721 aaacaagaaa aattctcatc tctgaaaagt ggcaaattaa tattttcctg ctaggcaacc
     3781 atccttgtgt tttatacaaa cataaagcgt tctgtggtgt gacagctttg gtgacagcat
     3841 ctctactgct ttgtacaaat cccatgtaaa tgtggtgaaa cacttcaaaa gcagagacag
     3901 catgaggatg caggcattcc agggaataca ctccatcatt ctatcagaca tgctgaaggt
     3961 gccattaagc ctaggatttt atcttttttt tttatgttaa ttcagaaagc agcatcagca
     4021 gtgaggtgtg accagtttgg atttgagggg acagatagac ttactatttg ttacctgttt
     4081 tttaataaac actaaaagca tcagaaatgt atttgtcatc tcagaaa
//
LOCUS       NM_057132               1892 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A (Rhoa), transcript
            variant 1, mRNA.
ACCESSION   NM_057132 XM_006243699
VERSION     NM_057132.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Liu,Q., Liu,C. and Lei,B.
  TITLE     siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative
            Induced Apoptosis in Retinal Ganglion Cells
  JOURNAL   Curr Mol Med 24 (5), 630-636 (2024)
   PUBMED   37171014
  REMARK    GeneRIF: siRNA Mediated Downregulation of RhoA Expression Reduces
            Oxidative Induced Apoptosis in Retinal Ganglion Cells.
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Shan,S., Su,M., Li,Y., Wang,Z., Liu,D., Zhou,Y., Fu,X., Yang,S.,
            Zhang,J., Qiu,J., Liu,H., Zeng,G., Chen,P., Wang,X., DiSanto,M.E.,
            Guo,Y. and Zhang,X.
  TITLE     Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles
  JOURNAL   Mol Med 29 (1), 139 (2023)
   PUBMED   37864185
  REMARK    GeneRIF: Mechanism of RhoA regulating benign prostatic hyperplasia:
            RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual
            roles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   Li,L., Wang,Q., Sun,X., Li,Z., Liu,S., Zhang,X., Zhou,J., Zhang,R.,
            Liu,K., Wang,P., Niu,J., Wen,Y. and Zhang,L.
  TITLE     Activation of RhoA pathway participated in the changes of emotion,
            cognitive function and hippocampal synaptic plasticity in juvenile
            chronic stress rats
  JOURNAL   Int J Biol Macromol 233, 123652 (2023)
   PUBMED   36780962
  REMARK    GeneRIF: Activation of RhoA pathway participated in the changes of
            emotion, cognitive function and hippocampal synaptic plasticity in
            juvenile chronic stress rats.
REFERENCE   6  (bases 1 to 1892)
  AUTHORS   Yoshimura,S., Sakai,H., Nakashima,S., Nozawa,Y., Shinoda,J.,
            Sakai,N. and Yamada,H.
  TITLE     Differential expression of Rho family GTP-binding proteins and
            protein kinase C isozymes during C6 glial cell differentiation
  JOURNAL   Brain Res Mol Brain Res 45 (1), 90-98 (1997)
   PUBMED   9105674
REFERENCE   7  (bases 1 to 1892)
  AUTHORS   Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
            Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
            Narumiya,S.
  TITLE     The small GTP-binding protein Rho binds to and activates a 160 kDa
            Ser/Thr protein kinase homologous to myotonic dystrophy kinase
  JOURNAL   EMBO J 15 (8), 1885-1893 (1996)
   PUBMED   8617235
REFERENCE   8  (bases 1 to 1892)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   9  (bases 1 to 1892)
  AUTHORS   Nemoto,Y., Namba,T., Teru-uchi,T., Ushikubi,F., Morii,N. and
            Narumiya,S.
  TITLE     A rho gene product in human blood platelets. I. Identification of
            the platelet substrate for botulinum C3 ADP-ribosyltransferase as
            rhoA protein
  JOURNAL   J Biol Chem 267 (29), 20916-20920 (1992)
   PUBMED   1328215
REFERENCE   10 (bases 1 to 1892)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 12, 2025 this sequence version replaced
            XM_006243699.3, NM_057132.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO793437.1, FO815825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  117870535-117870689
            156-230             JAXUCZ010000008.1  117880565-117880639
            231-388             JAXUCZ010000008.1  117894634-117894791
            389-509             JAXUCZ010000008.1  117897631-117897751
            510-640             JAXUCZ010000008.1  117901968-117902098
            641-1892            JAXUCZ010000008.1  117903052-117904303
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1892
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
     exon            1..155
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..230
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    227..229
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="upstream in-frame stop codon"
     exon            231..388
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..814
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /EC_number="3.6.5.2"
                     /note="plysia ras-related homolog A2; ras homolog gene
                     family, member A"
                     /codon_start=1
                     /product="transforming protein RhoA"
                     /protein_id="NP_476473.1"
                     /db_xref="GeneID:117273"
                     /db_xref="RGD:619921"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
                     AKTKDGVREVFEMATRAALQARRGKKKSGCLIL"
     mat_peptide     233..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /product="Transforming protein RhoA. /id=PRO_0000030415"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1)"
     misc_feature    245..769
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    245..769
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(245..247,332..334,341..346,353..355,359..361,
                     365..367,392..394,404..409,413..421,428..430,434..436,
                     446..448)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(245..247,332..334,341..346,353..355,359..361,
                     365..367,392..394,404..409,413..421,428..430,434..436,
                     446..448)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    266..289
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    266..289
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(275..292,332..337,341..343,407..412,584..586,
                     590..592,713..718)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(275..292,332..337,341..343,407..412,584..586,
                     590..592,713..718)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(299..301,305..319,356..361,365..373,386..394,
                     719..724,734..739,746..748)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(299..301,305..319,356..361,365..373,386..394,
                     719..724,734..739,746..748)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(332..334,338..340,344..349,419..430,437..439,
                     446..448,512..514)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(332..334,338..340,344..349,419..430,437..439,
                     446..448,512..514)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    332..358
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Effector region. /evidence=ECO:0000255"
     misc_feature    332..358
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    332..358
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(341..346,413..415,428..430,434..439,443..448,
                     455..457,545..550,554..556)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(341..346,413..415,428..430,434..439,443..448,
                     455..457,545..550,554..556)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    341..343
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    341..343
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(347..349,425..439,446..448,521..523,533..535,
                     545..547)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(347..349,425..439,446..448,521..523,533..535,
                     545..547)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(347..352,425..430,434..439,446..448)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(347..352,425..430,434..439,446..448)
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    407..418
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    407..418
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    413..466
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61589.1);
                     Region: Switch II region, involved in RAP1GDS1 binding.
                     /evidence=ECO:0000250|UniProtKB:P61586"
     misc_feature    416..469
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    416..469
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    581..592
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    581..592
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    710..718
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    710..718
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    794..796
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Phosphoserine, by PKG/PRKG1 and SLK.
                     /evidence=ECO:0000269|PubMed:18420945; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); phosphorylation site"
     misc_feature    800..802
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61585; propagated from
                     UniProtKB/Swiss-Prot (P61589.1); methylation site"
     exon            389..509
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..640
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..1892
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgcgctc cccgcccgcc gcccgcggtc ctccgtcggt tctctcctta gcccgccgtc
       61 tcccacggag ctgctcgccc ttgtctcgga gctcgcggac tcgcggacag gcgtcctcag
      121 cgcgaagagg ccggattcgg agtcgtcgtc ttgagccttg catctaagaa gtcccaggta
      181 ctttgtacaa ctgcatccca gaagctgagt ttcttcagca ccttcataag tgatggctgc
      241 catcaggaag aaactggtga ttgttggtga tggagcttgt ggtaagacat gcttgctcat
      301 agtcttcagc aaggaccagt tcccagaggt ttatgtgccc acggtgtttg aaaactatgt
      361 ggcagatatt gaagtggacg ggaagcaggt agagttggct ttatgggaca cagctggaca
      421 ggaagattat gaccgtctga ggcctctctc ctacccagac actgatgtta tactgatgtg
      481 tttttccatc gacagccctg atagtttaga aaacatccca gaaaaatgga ctccagaagt
      541 caagcatttc tgtccaaatg tgcccatcat cctagttggg aacaagaagg atcttcggaa
      601 tgatgagcac acaaggcggg agttagccaa aatgaagcag gagccggtaa aacctgaaga
      661 aggcagagat atggcaaaca ggattggcgc ttttgggtac atggagtgtt cagcaaagac
      721 caaagacgga gtgagagagg tttttgagat ggccacgaga gctgctctgc aagctagacg
      781 cgggaagaaa aagtcggggt gcctcatctt gtgaagcctt gtgacgcgca gcctcatgcg
      841 gttaatttga agtgctgttt attaatctta gtgtatgatt actggccttt tcatttatct
      901 ataatttacc taagattaca aatcagaagt catcttgcta ccagtattta gaagccaacc
      961 atgattatta atgatgtcca gcctgtctga ccagccaggg tccttctgac actgctctaa
     1021 cgccctctct gcactccacc tgacaccagg cgctcattca aagaatttct taacttcctg
     1081 cttctttcta gaaagagaaa cagttggtaa cttttgtgaa ttaggctgta actactttat
     1141 aactaacatg tcctgcctat tttctgtcag ctgcgaggaa ctctggtgag tcactacttc
     1201 agagctttac tccttaacag attccattgg cagagctctg gggtgggcac ccagtgtttg
     1261 gaaacttgat cagccagaaa ggcccaagtc cacgcagctg tggcagagtt acagttctgt
     1321 ggtctcatgt tagttacctt atagttactg tgtaattagt gccacttaat gtatgttacc
     1381 aaaaataaat atatctaccc cagactagat gtagtatttt ttgtataatt ggatttccta
     1441 attctgatat ttgtcattcc cacagaaagt gtattgcttt tttttttttt taagaaagta
     1501 tttggaaata aagtcagatg gaaaattcat ttttaaaatt cccattttgt cactttctct
     1561 gataaaatat ggccatatct cccctattta gccctatata tcattccagt gcccctttcc
     1621 agactggact gaggaaatag gaattggttt catgcctgag gctgttagac tttggaggtg
     1681 gcatagcctt tctcacctgg actgcagggc ctggctctaa gtcacagtgc tcctttctcc
     1741 acactgttat ccaagtcgcc tcccagagga gccaccagtt cttatgggtg gcaatgggtg
     1801 ggtgggtggg gggtctcctc tctccagctg actaaacttt tttctgtacc agttaatttt
     1861 tccaactaat agaataaagg cagttttcta aa
//
LOCUS       NM_001436650            3112 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus SPARC/osteonectin, cwcv and kazal like domains
            proteoglycan 3 (Spock3), transcript variant 2, mRNA.
ACCESSION   NM_001436650 XM_017600105
VERSION     NM_001436650.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Nakada,M., Yamada,A., Takino,T., Miyamori,H., Takahashi,T.,
            Yamashita,J. and Sato,H.
  TITLE     Suppression of membrane-type 1 matrix metalloproteinase
            (MMP)-mediated MMP-2 activation and tumor invasion by testican 3
            and its splicing variant gene product, N-Tes
  JOURNAL   Cancer Res 61 (24), 8896-8902 (2001)
   PUBMED   11751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_017600105.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.475668.1,
                                           SRR26360194.1486073.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000016.1  31581818-31581929   c
            113-301             JAXUCZ010000016.1  31581357-31581545   c
            302-347             JAXUCZ010000016.1  31413059-31413104   c
            348-462             JAXUCZ010000016.1  31380705-31380819   c
            463-586             JAXUCZ010000016.1  31300481-31300604   c
            587-701             JAXUCZ010000016.1  31266027-31266141   c
            702-821             JAXUCZ010000016.1  31173617-31173736   c
            822-1043            JAXUCZ010000016.1  31159816-31160037   c
            1044-1106           JAXUCZ010000016.1  31156710-31156772   c
            1107-1244           JAXUCZ010000016.1  31154089-31154226   c
            1245-3112           JAXUCZ010000016.1  31149698-31151565   c
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..3112
                     /gene="Spock3"
                     /note="SPARC/osteonectin, cwcv and kazal like domains
                     proteoglycan 3"
                     /db_xref="GeneID:306404"
                     /db_xref="RGD:1305672"
     exon            1..112
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1411
                     /gene="Spock3"
                     /note="testican-3; sparc/osteonectin, cwcv and kazal-like
                     domains proteoglycan 3; sparc/osteonectin, cwcv and
                     kazal-like domains proteoglycan (testican) 3"
                     /codon_start=1
                     /product="testican-3 precursor"
                     /protein_id="NP_001423579.1"
                     /db_xref="GeneID:306404"
                     /db_xref="RGD:1305672"
                     /translation="MLKVSALLCVCAAAWCSQTLAAAAAVAVAGGRSDGGNFLDEKQW
                     LTTVSQYDKEVGQWNKFRDDDYFRTWNPGKPIDQALDPARDPCLKTKCSRHKVCITQD
                     AQTALCISHRRLTHSMKEVGGSHKQWRGLPSSTCKQCPIAYASPVCGSDGHSYSSQCK
                     LEYQACVLGKQISIKCEGRCPCPSDKSMSTGRNVKRACSDLEFREVANRLRDWFKALH
                     ESGSQNKRTKALLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYLD
                     KNEHCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCHTELSKIQKRQGIKKLLGQY
                     LPLCDEDGFYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADCAIDFEISGDFASGDF
                     REWTDDEGEEDDMNDKDDIEDDDEDEGDDDDDGDDHDGYI"
     sig_peptide     113..175
                     /gene="Spock3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    512..652
                     /gene="Spock3"
                     /note="Kazal-type serine protease inhibitor domain;
                     Region: Kazal_2; pfam07648"
                     /db_xref="CDD:400135"
     misc_feature    512..652
                     /gene="Spock3"
                     /note="Kazal-type serine protease inhibitor domain;
                     Region: Kazal_2; pfam07648"
                     /db_xref="CDD:400135"
     misc_feature    704..1042
                     /gene="Spock3"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in testican-3 (TICN3); Region: EFh_SPARC_TICN3;
                     cd16239"
                     /db_xref="CDD:320018"
     misc_feature    704..1042
                     /gene="Spock3"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in testican-3 (TICN3); Region: EFh_SPARC_TICN3;
                     cd16239"
                     /db_xref="CDD:320018"
     misc_feature    848..943
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    848..943
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    order(884..886,896..898,917..919)
                     /gene="Spock3"
                     /note="putative Ca binding site [ion binding]; other site"
                     /db_xref="CDD:320018"
     misc_feature    order(884..886,896..898,917..919)
                     /gene="Spock3"
                     /note="putative Ca binding site [ion binding]; other site"
                     /db_xref="CDD:320018"
     misc_feature    944..1042
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    944..1042
                     /gene="Spock3"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320018"
     misc_feature    1052..1243
                     /gene="Spock3"
                     /note="Thyroglobulin type-1 repeat; Region:
                     Thyroglobulin_1; pfam00086"
                     /db_xref="CDD:459665"
     misc_feature    1052..1243
                     /gene="Spock3"
                     /note="Thyroglobulin type-1 repeat; Region:
                     Thyroglobulin_1; pfam00086"
                     /db_xref="CDD:459665"
     misc_feature    order(1064..1066,1109..1111,1163..1165,1175..1177)
                     /gene="Spock3"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     misc_feature    order(1064..1066,1109..1111,1163..1165,1175..1177)
                     /gene="Spock3"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     exon            113..301
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..347
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            348..462
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..586
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..701
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..821
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1043
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1106
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1244
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..3112
                     /gene="Spock3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggacgg ctgagacggc ggcgcgtgca gcagctccag cgagaagcga gttgccagag
       61 ccaggctgca tttccatcag gagctgcgag ctccgtgccc gctcccagca agatgctcaa
      121 ggtgtcagcc ttattgtgtg tgtgtgcagc ggcttggtgc agccagactc ttgcagctgc
      181 tgcggcggtg gctgtggccg gggggcggtc ggacggcggt aattttctgg atgaaaaaca
      241 atggctcacc acagtctctc agtatgacaa ggaagtcgga cagtggaaca aattccgaga
      301 cgatgattat ttccgcactt ggaatcctgg aaaaccaatt gatcaagctt tagatcctgc
      361 tagggaccca tgcttaaaga cgaaatgcag ccgccacaaa gtctgcatta ctcaagatgc
      421 tcagactgca ctgtgcatca gtcaccggag gctcacacac agtatgaaag aagtaggagg
      481 aagccataag caatggagag gtctcccgtc atctacctgt aagcagtgcc ctatagccta
      541 tgccagcccg gtctgtggtt ccgatgggca ttcttactct tcacagtgca aactagaata
      601 tcaggcatgt gtcttaggaa aacagatctc tatcaaatgt gaagggcgat gcccgtgtcc
      661 ctccgataag tccatgagca caggcagaaa tgtaaagaga gcctgcagtg acctggaatt
      721 cagagaagtg gcaaacagac tgcgagactg gttcaaggcg cttcatgaga gtggaagcca
      781 gaacaagagg acaaaagcat tgctgaggcc tgagagaagc aggtttgata ccagtatttt
      841 gccaatttgc aaggattcac ttggctggat gtttaataga cttgatacaa actacgacct
      901 gttattggac cagtcagagc ttggcagcat ttaccttgat aagaatgagc attgcaccaa
      961 ggcgttcttc aactcttgtg atacatacaa ggacagtttg atatctaaca atgaatggtg
     1021 ctactgcttc cagagacagc aagacccacc ttgccacact gagctcagca aaattcagaa
     1081 gcgacaaggg ataaagaagc tcctaggaca gtacctccca ctctgtgatg aagatggttt
     1141 ctacaagcca acacaatgcc atggaagtgt agggcagtgc tggtgtgttg acagatatgg
     1201 aaatgaagtt gtgggatcta gaataaatgg tgttgcagat tgtgctatag actttgagat
     1261 ttctggagac tttgcaagtg gagattttcg tgaatggact gatgatgaag gtgaagaaga
     1321 tgacatgaat gataaggatg atattgaaga cgatgatgaa gatgaagggg atgatgatga
     1381 tgatggggat gaccacgatg gatatatctg accagtgaca actaatgtca atgaattcta
     1441 catttttaat atttacaata ataatagcat attgagaatt tccttcttat ccctaaacaa
     1501 agtgattcta aacccgacat atattttgta taattatttc aaatattgaa gctaaaatca
     1561 tagaacttta tgtttaaatt agaattattt agtttcagtt ttcatatgcc ttagaaaaaa
     1621 aggaaacaca tatgggttgc agcctgaata taaaagttgt aaagattact gtaacaaaat
     1681 ttcataagaa aatacagaca aataaaataa caatgaatgt gtgcttggga tcctgtgtgt
     1741 tgcttttaat gacagatttt ataagttaaa tttatggtag cttgctaatg acatgaacca
     1801 caataatttc atcaattaat tcctaatgta gatttcaatt caaacttaac atcttcccaa
     1861 actaatggtt ggcatattaa gaaaaatggc tcatggtaaa atggaatggt tttcatttta
     1921 attatgaaat tattctgggt attattagat attacatgca atgcaacgtg tggtaatcct
     1981 tgggtgctga aagttaaaac cttagtcttt ctttctactt tgtaatttta atggcattgc
     2041 ttatcaggta gaattttaaa aatattccta gacatcctca tttctagatt tctctctctg
     2101 actagtaatt atgtatagaa tttcagttag aaagaaacag actcatttca acaactgttc
     2161 cattaaatat attttatttg caccaaggtc aattttgaaa ccatggactc tcagttttag
     2221 ttttcatttt ctatgagatt ttgcatttga tcttggaatc atgccatttt tttagtggta
     2281 ctaaaattag agaccgtgtt gtatggtgcc ttgcaaaaat agaaatagaa agggttagca
     2341 tgtatatcag tataagagac taggcaatgt gtaagcacac ataattaaca aattattgat
     2401 attaaaatag tgctgaaatg aagaaaaatg gaatatgttt ctttcttttt ttctattgtt
     2461 acataatccc atatggactt gtttataatt attgtgaaga atagcattta agattaactg
     2521 taccaaaagt tactttgctc actatacatc agttagcatg ttaattgtgt agatattttg
     2581 acataccacc acctttgggt atatcagacc aatagttttg tgctcataac agaagtggga
     2641 aaacctgttg aaatttacac attgatatct ttcacttcaa cattgaattt acagatttcc
     2701 tggaatatta ttcataagaa cacaaatttg gtgaactctt gccatttaat ttatatacaa
     2761 gaaataaaaa ctttaatctt gaacttacat ataatattta agctataatg tattttcttt
     2821 tttattgttt atgtatagtt tacgaaataa agaatcttgt aaccaaagta aacagttctt
     2881 aatgattttc tgggatatat atataatagc atgaagagtt tttaatttat tccttaactc
     2941 tacaaaataa catgccacac cagagtcaag aaatatttct gagtttactt ttacagtttg
     3001 taaatctgag ttgttattgt attaagtaca ataagattat ctatctttgt tggtttattt
     3061 taacccgttt atttgtcata atattgcaaa ataaatactt ttctttccaa aa
//
LOCUS       NM_133573               2354 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled estrogen receptor 1 (Gper1),
            transcript variant 2, mRNA.
ACCESSION   NM_133573 XM_006248914
VERSION     NM_133573.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Zhang,Y.Q., Sun,T., Zhao,Z., Fu,J., Yang,L., Xu,Y., Zhao,J.F.,
            Tang,X.L., Liu,A. and Zhao,M.G.
  TITLE     Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion
            Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling
            Pathway
  JOURNAL   Neuromolecular Med 26 (1), 33 (2024)
   PUBMED   39138706
  REMARK    GeneRIF: Activation of GPR30 Ameliorates Cerebral
            Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through
            Nrf2/GPX4 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Grubic Kezele,T., Omrcen,H., Baticic,L., Sucurovic,S. and Zoricic
            Cvek,S.
  TITLE     Joint Inflammation Correlates with Joint GPR30 Expression in Males
            and Hippocampal GPR30 Expression in Females in a Rat Model of
            Rheumatoid Arthritis
  JOURNAL   Int J Mol Sci 25 (14), 7864 (2024)
   PUBMED   39063107
  REMARK    GeneRIF: Joint Inflammation Correlates with Joint GPR30 Expression
            in Males and Hippocampal GPR30 Expression in Females in a Rat Model
            of Rheumatoid Arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Azizian,H., Farhadi,Z., Bader,M., Alizadeh Ghalenoei,J.,
            Ghafari,M.A. and Mahmoodzadeh,S.
  TITLE     GPER activation attenuates cardiac dysfunction by upregulating the
            SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats
  JOURNAL   PLoS One 18 (12), e0293630 (2023)
   PUBMED   38134189
  REMARK    GeneRIF: GPER activation attenuates cardiac dysfunction by
            upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   Hu,J., Huang,Y., Gao,F., Sun,W., Liu,H., Ma,H., Yuan,T., Liu,Z.,
            Tang,L., Ma,Y., Zhang,X., Bai,J. and Wang,R.
  TITLE     Brain-derived estrogen: a critical player in maintaining cognitive
            health of aged female rats, possibly involving GPR30
  JOURNAL   Neurobiol Aging 129, 15-27 (2023)
   PUBMED   37257405
  REMARK    GeneRIF: Brain-derived estrogen: a critical player in maintaining
            cognitive health of aged female rats, possibly involving GPR30.
REFERENCE   5  (bases 1 to 2354)
  AUTHORS   Xu,X., Wang,J., Guo,X., Chen,Y., Ding,S., Zou,G., Zhu,L., Li,T. and
            Zhang,X.
  TITLE     GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2
  JOURNAL   Front Immunol 14, 1106771 (2023)
   PUBMED   36845134
  REMARK    GeneRIF: GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2354)
  AUTHORS   Sakamoto,H., Matsuda,K., Hosokawa,K., Nishi,M., Morris,J.F.,
            Prossnitz,E.R. and Kawata,M.
  TITLE     Expression of G protein-coupled receptor-30, a G protein-coupled
            membrane estrogen receptor, in oxytocin neurons of the rat
            paraventricular and supraoptic nuclei
  JOURNAL   Endocrinology 148 (12), 5842-5850 (2007)
   PUBMED   17872373
  REMARK    GeneRIF: Results suggest that GPR30 may serve primarily as a
            nongenomic transducer of estrogen actions in the
            hypothalamo-neurohypophyseal system.
REFERENCE   7  (bases 1 to 2354)
  AUTHORS   Funakoshi,T., Yanai,A., Shinoda,K., Kawano,M.M. and Mizukami,Y.
  TITLE     G protein-coupled receptor 30 is an estrogen receptor in the plasma
            membrane
  JOURNAL   Biochem Biophys Res Commun 346 (3), 904-910 (2006)
   PUBMED   16780796
  REMARK    GeneRIF: GPR30, a transmembrane receptor for estrogen, is localized
            to the plasma membrane of CA2 pyramidal neuronal cells of the
            hippocampus in rat brain
REFERENCE   8  (bases 1 to 2354)
  AUTHORS   Revankar,C.M., Cimino,D.F., Sklar,L.A., Arterburn,J.B. and
            Prossnitz,E.R.
  TITLE     A transmembrane intracellular estrogen receptor mediates rapid cell
            signaling
  JOURNAL   Science 307 (5715), 1625-1630 (2005)
   PUBMED   15705806
REFERENCE   9  (bases 1 to 2354)
  AUTHORS   Thomas,P., Pang,Y., Filardo,E.J. and Dong,J.
  TITLE     Identity of an estrogen membrane receptor coupled to a G protein in
            human breast cancer cells
  JOURNAL   Endocrinology 146 (2), 624-632 (2005)
   PUBMED   15539556
REFERENCE   10 (bases 1 to 2354)
  AUTHORS   Bonini,J.A., Anderson,S.M. and Steiner,D.F.
  TITLE     Molecular cloning and tissue expression of a novel orphan G
            protein-coupled receptor from rat lung
  JOURNAL   Biochem Biophys Res Commun 234 (1), 190-193 (1997)
   PUBMED   9168987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 12, 2025 this sequence version replaced
            XM_006248914.5, NM_133573.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2159302.1,
                                           SRR26643298.79811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000012.1  20335552-20335727   c
            177-2354            JAXUCZ010000012.1  20331073-20333250   c
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2354
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
     exon            1..176
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     exon            177..2354
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    382..384
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="upstream in-frame stop codon"
     CDS             403..1530
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="mER; chemokine receptor-like 2; membrane estrogen
                     receptor; G-protein coupled receptor 30; G-protein coupled
                     receptor 41; chemoattractant receptor-like 2"
                     /codon_start=1
                     /product="G-protein coupled estrogen receptor 1"
                     /protein_id="NP_598257.2"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
                     /translation="MAATTPAQDVGVEIYLGPVWPAPSNSTPLALNLSLALREDAPGN
                     LTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLA
                     AADLILVADSLIEVFNLDEQYYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALA
                     KAMRCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLRHTEEACFCFADVREVQWLE
                     VTLGFIVPFAIIGLCYSLIVRALIRAHRHRGLRPRRQKALRMIFAVVLVFFICWLPEN
                     VFISVHLLQWAQPGDTPCKQSFRHAYPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDK
                     LRLYVAQKTSLPALNRFCHATLKAVIPDSTEQSDVKFSSAV"
     misc_feature    403..405
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q99527; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); acetylation site"
     misc_feature    496..498
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); glycosylation site"
     misc_feature    532..534
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08878.1); glycosylation site"
     misc_feature    580..1407
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPER1; cd14989"
                     /db_xref="CDD:320120"
     misc_feature    580..1407
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPER1; cd14989"
                     /db_xref="CDD:320120"
     misc_feature    583..663
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320120"
     misc_feature    583..663
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320120"
     misc_feature    589..654
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    682..759
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320120"
     misc_feature    682..759
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320120"
     misc_feature    691..762
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    order(745..747,754..759,790..807,811..816,823..825,
                     958..960,964..978,1033..1035,1042..1050,1054..1062,
                     1066..1071,1216..1218,1225..1230,1234..1239,1246..1248,
                     1306..1311,1315..1323,1330..1332,1339..1344)
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320120"
     misc_feature    order(745..747,754..759,790..807,811..816,823..825,
                     958..960,964..978,1033..1035,1042..1050,1054..1062,
                     1066..1071,1216..1218,1225..1230,1234..1239,1246..1248,
                     1306..1311,1315..1323,1330..1332,1339..1344)
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320120"
     misc_feature    790..882
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320120"
     misc_feature    790..882
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320120"
     misc_feature    799..861
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    919..984
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320120"
     misc_feature    919..984
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320120"
     misc_feature    928..984
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1033..1116
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320120"
     misc_feature    1033..1116
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320120"
     misc_feature    1063..1110
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1156..1248
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320120"
     misc_feature    1156..1248
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320120"
     misc_feature    1180..1242
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
     misc_feature    1309..1386
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320120"
     misc_feature    1309..1386
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320120"
     misc_feature    1321..1383
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="propagated from UniProtKB/Swiss-Prot (O08878.1);
                     transmembrane region"
ORIGIN      
        1 acaggcatcc acaggcatgg tgagcctgct cccttccaga cctgacactc ttcttttcct
       61 ctcctgctgt atccctgctg ggcaccatcc ccaaggtgct acgagtccag ggacaatccc
      121 tgtgagcaac ctccagaagc acctccagca gatggttcag tgactccatg gcccaggtcc
      181 tcagaaggta agcaggcagc aggcgttcct gcccggcacc agcccagacg ccctgtctgc
      241 ccttctggtt ttctgagaca aacaggctcc caggacgatt cttcctgcct cacgcatgcc
      301 tggctcactt cccagggaat cacctttgtg aagatggagc tgtcacgtaa aacagacttc
      361 tgtgaccctt tcagcaagtc ctgaaagctt ctacgggaag ccatggctgc aactactcca
      421 gcacaagatg ttggcgtaga gatctaccta ggtcccgtgt ggccagcccc ttccaacagc
      481 acccctctgg ccctcaacct gtccctggcg ctgcgggaag atgccccggg gaacctcact
      541 ggggacctct ctgaacatca gcaatatgtg atcgctctct tcctctcctg cctctacacc
      601 atcttcctct tccccatcgg ctttgtgggc aacatcctca tcttggtggt gaacatcagc
      661 ttccgggaga agatgactat cccagacctg tacttcatca acctggcagc ggccgacctc
      721 atcctggtgg ccgactccct gatcgaggtg ttcaacctgg acgagcagta ctacgatatc
      781 gccgtgctct gcaccttcat gtccctcttc ctgcagatca acatgtacag cagcgtcttc
      841 ttcctcacct ggatgagctt cgacaggtac ctggcgctgg ccaaagccat gcgctgtggc
      901 ctcttccgca ccaagcacca cgcgcggctc agctgtggcc tcatctggat ggcctcagtg
      961 tccgccacgc tggtgccctt cacggccgtg catctgcggc acaccgagga ggcctgcttc
     1021 tgctttgccg atgtcaggga ggtgcagtgg ctggaggtca cgctgggctt cattgtgccc
     1081 ttcgccatca tcggcctgtg ctattccctc atcgtgcggg ccctcatccg ggcccacagg
     1141 catcgtggcc tgcgcccacg caggcagaaa gccctgagga tgatcttcgc agtggtcctt
     1201 gtcttcttca tctgctggct gccggagaac gtcttcatca gcgtccacct actgcagtgg
     1261 gcgcagccag gggacactcc ctgcaagcag tctttccgtc atgcctaccc cttgacaggc
     1321 cacatagtca acctggcagc cttctccaac agctgcctga atcccctcat ctatagcttc
     1381 ctgggagaga ccttcaggga caagctcagg ctgtatgtgg cgcagaagac gagcctgcca
     1441 gctctcaacc gcttctgcca tgccacgctc aaggcagtca taccagacag cacggagcag
     1501 tcagatgtca agttcagcag tgctgtatga gaggtacctc ctagaggaaa acggacaggg
     1561 gagcaggcgt gcccaggagc tgcacactcc tagcacaggt ggtgggcgag ctgagccatg
     1621 tcatactcta aaccccagtg gctaggggga aatgtcacat ggctgggtca cctctggggc
     1681 tgctgggatt cttcctgact gcccagctca tggatactgc catccagatt caaggcagtg
     1741 ggccacatga cattgacctc tgccctcaaa gggcaccacg aaggcctgac gcttggtttt
     1801 ctttccatac cctatgtttc cagaagacaa gtctgttgtt gattaagtaa cagcccaaag
     1861 gacaggccac cctatggcac taccatggtt atatcttctg ttacgtgcct gctacacgga
     1921 agagcctaga aacagagcat atgtaccaga cccaaactgg ctacgttccc tttgcttgtg
     1981 acgtgtgatt gatcatgtac actctgtcca gtgcagccaa agctaaggac cccagagcct
     2041 tcttcctgtc ttccagaagg ctgtgaggtc atcccagatg ccactcctaa ctcctcagtg
     2101 aacagcatgt ctgagctgag aaaggccctt taacaaacca cctccctgct ctgggatgct
     2161 cctctcacaa agcttgttta caaaggtgtt tgcccttctg tgaaggtgga aggagaccgt
     2221 gggtgctgct gtgcaggctg ctgggaatcc catcataaga catttgtcgg aaggacttga
     2281 ctccacagaa aataatactg ggaacggtga gctgtaaacg gatctcatta aaatgtaaaa
     2341 agaaagaaca agaa
//
LOCUS       NM_022592               2086 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus transketolase (Tkt), transcript variant 4, mRNA.
ACCESSION   NM_022592
VERSION     NM_022592.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2086)
  AUTHORS   Zhao,Y., Wu,Y., Hu,H., Cai,J., Ning,M., Ni,X. and Zhong,C.
  TITLE     Downregulation of transketolase activity is related to inhibition
            of hippocampal progenitor cell proliferation induced by thiamine
            deficiency
  JOURNAL   Biomed Res Int 2014, 572915 (2014)
   PUBMED   25028661
  REMARK    GeneRIF: results suggest that modulation of transketolase activity
            might be one of the mechanisms by which thiamine regulates the
            proliferation of hippocampal progenitor cells.
REFERENCE   2  (bases 1 to 2086)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2086)
  AUTHORS   Mitschke,L., Parthier,C., Schroder-Tittmann,K., Coy,J., Ludtke,S.
            and Tittmann,K.
  TITLE     The crystal structure of human transketolase and new insights into
            its mode of action
  JOURNAL   J Biol Chem 285 (41), 31559-31570 (2010)
   PUBMED   20667822
REFERENCE   4  (bases 1 to 2086)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 2086)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2086)
  AUTHORS   Wang,J.J., Martin,P.R. and Singleton,C.K.
  TITLE     Aspartate 155 of human transketolase is essential for thiamine
            diphosphate-magnesium binding, and cofactor binding is required for
            dimer formation
  JOURNAL   Biochim Biophys Acta 1341 (2), 165-172 (1997)
   PUBMED   9357955
REFERENCE   7  (bases 1 to 2086)
  AUTHORS   McCool,B.A., Plonk,S.G., Martin,P.R. and Singleton,C.K.
  TITLE     Cloning of human transketolase cDNAs and comparison of the
            nucleotide sequence of the coding region in Wernicke-Korsakoff and
            non-Wernicke-Korsakoff individuals
  JOURNAL   J Biol Chem 268 (2), 1397-1404 (1993)
   PUBMED   8419340
REFERENCE   8  (bases 1 to 2086)
  AUTHORS   Abedinia,M., Layfield,R., Jones,S.M., Nixon,P.F. and Mattick,J.S.
  TITLE     Nucleotide and predicted amino acid sequence of a cDNA clone
            encoding part of human transketolase
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1159-1166 (1992)
   PUBMED   1567394
REFERENCE   9  (bases 1 to 2086)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   10 (bases 1 to 2086)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09256.1, SRR26643295.51883.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000016.1  5730232-5730308
            78-210              JAXUCZ010000016.1  5730932-5731064
            211-328             JAXUCZ010000016.1  5740422-5740539
            329-442             JAXUCZ010000016.1  5741405-5741518
            443-540             JAXUCZ010000016.1  5742133-5742230
            541-732             JAXUCZ010000016.1  5747104-5747295
            733-851             JAXUCZ010000016.1  5748625-5748743
            852-1045            JAXUCZ010000016.1  5749659-5749852
            1046-1210           JAXUCZ010000016.1  5750484-5750648
            1211-1367           JAXUCZ010000016.1  5751274-5751430
            1368-1498           JAXUCZ010000016.1  5751544-5751674
            1499-1582           JAXUCZ010000016.1  5752336-5752419
            1583-1676           JAXUCZ010000016.1  5752527-5752620
            1677-1799           JAXUCZ010000016.1  5753474-5753596
            1800-2086           JAXUCZ010000016.1  5754882-5755168
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2086
                     /gene="Tkt"
                     /note="transketolase"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
     exon            1..77
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1975
                     /gene="Tkt"
                     /EC_number="2.2.1.1"
                     /note="isoform 4 is encoded by transcript variant 4; TK"
                     /codon_start=1
                     /product="transketolase isoform 4"
                     /protein_id="NP_072114.2"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
                     /translation="MDPVRQIQCDREGKRFPFLSAPPASTSSPDRAMEGYHKPDQQKL
                     QALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDR
                     FVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQG
                     LGAACGMAYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINR
                     LGQSDPAPLQHQVDVYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFK
                     GRGITGIEDKEAWHGKPLPKNMAEQIIQEIYSQVQSKKKILATPPQEDAPSVDIANIR
                     MPTPPNYKVGDKIATRKAYGLALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFI
                     ECYIAEQNMVSIAVGCATRDRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCG
                     VSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPE
                     NAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAEMLKKEKIGVRVLDP
                     FTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAAVVGEPGVTVTRLAVSQV
                     PRSGKPAELLKMFGIDKDAIVQAVKGLVTKG"
     misc_feature    125..1963
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    125..1963
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     exon            78..210
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            211..328
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            329..442
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            443..540
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            541..732
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            733..851
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1045
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1210
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1367
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1498
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1582
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1676
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1799
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2086
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatgtcatg gatccagtga gacagatcca gtgcgaccgt gaaggcaaac gctttccgtt
       61 cctctcagct ccaccagctt ccacgtcctc gcccgaccgc gccatggagg gttaccataa
      121 gccagatcag cagaagctcc aggccctgaa ggacacagcc aatcgcctgc gcatcagctc
      181 catccaggcc accaccgcgg caggctcggg acaccccaca tcatgctgca gcgctgccga
      241 gatcatggct gtcctgtttt tccataccat gcgctacaag gccctggatc cccgaaaccc
      301 tcacaatgat cgctttgtgc tctccaaggg ccatgcagct cccatcttat atgcagtctg
      361 ggctgaagct ggcttcctgc ctgaggcaga gctgctgaac ctgaggaaaa tcagctctga
      421 cttggatggg catcctgtcc cgaaacaagc cttcaccgat gtggccactg gctccctggg
      481 ccaggggctg ggagctgcgt gcgggatggc atacacaggc aaatacttcg acaaagccag
      541 ctaccgagtc tattgcatgc tgggagacgg ggaggtgtcc gagggctccg tttgggaggc
      601 catggccttc gctggaattt acaagctgga caacctcgtt gccatttttg acatcaaccg
      661 tctgggccag agcgacccag ccccgctgca gcaccaagtg gacgtctacc agaagcgctg
      721 tgaggccttt ggctggcatg ccatcatcgt ggatgggcac agtgtggagg agctgtgcaa
      781 ggcctttggt caggccaagc accaaccaac agccatcatt gccaagacct tcaagggccg
      841 cgggatcaca gggattgaag acaaggaggc gtggcatggg aagcccctcc ccaaaaacat
      901 ggctgagcag attatccagg agatttacag ccaggttcag agcaaaaaga agatcctcgc
      961 cacgccccct caggaggatg ccccttccgt ggacattgcc aacatccgaa tgcctacccc
     1021 acccaactac aaagtggggg acaagatagc cacacggaaa gcctatggat tggcccttgc
     1081 caagctgggc cacgccagtg accgcatcat cgccctggat ggagacacca aaaattccac
     1141 cttctcagag ctcttcaaaa aggagcaccc agaccgtttc atcgagtgct acattgctga
     1201 gcagaacatg gtgagcattg ctgtgggctg tgccacacgt gacaggacag tgcccttctg
     1261 cagcactttt gcggccttct tcacacgcgc cttcgaccag atccgcatgg ccgccatctc
     1321 cgagagcaac atcaacctct gtggctccca ttgcggcgtg tccattgggg aagacgggcc
     1381 ctcgcagatg gccctggaag acctggccat gtttcggtcg gtccctatgt ccaccgtctt
     1441 ttacccaagt gatggagttg ccacagagaa ggcagtggaa ttagcagcca atacaaaggg
     1501 catctgcttc attcggacca gccgcccaga aaatgccatt atctatagca acaacgagga
     1561 tttccaggtt ggccaagcca aggtggtcct gaagagcaag gacgaccaag tgacggtgat
     1621 cggggctggc gtaactctgc acgaggctct ggctgctgca gagatgttga agaaagagaa
     1681 gatcggcgtc cgtgtactgg accccttcac catcaagccc ctggacaaaa agctcattct
     1741 cgactgtgcc agagcaacca aaggcaggat cctcaccgtg gaggaccact actatgaagg
     1801 tggcataggc gaggcagtat ctgctgcggt agtgggcgaa cctggagtca cagtcactcg
     1861 cctggcggtc agccaagtac cacgaagtgg gaagccagct gagctgctga agatgtttgg
     1921 tattgacaaa gacgccattg tgcaagctgt gaagggcctt gtcaccaagg gctaggaagg
     1981 acatgggatg ccgggtgggt gaactacaca ttccagggat gttctggcaa aggtgctcaa
     2041 gggtgtaccg agtggaaagg taaatatatg ttttgagaaa aaaatt
//
LOCUS       NM_001436618            5564 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 2
            (Cdk5rap2), transcript variant 1, mRNA.
ACCESSION   NM_001436618 XM_063287224
VERSION     NM_001436618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5564)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   2  (bases 1 to 5564)
  AUTHORS   Gao,F.J., Shi,L., Hines,T., Hebbar,S., Neufeld,K.L. and Smith,D.S.
  TITLE     Insulin signaling regulates a functional interaction between
            adenomatous polyposis coli and cytoplasmic dynein
  JOURNAL   Mol Biol Cell 28 (5), 587-599 (2017)
   PUBMED   28057765
REFERENCE   3  (bases 1 to 5564)
  AUTHORS   Park,J.S., Lee,M.K., Kang,S., Jin,Y., Fu,S., Rosales,J.L. and
            Lee,K.Y.
  TITLE     Species-Specific Expression of Full-Length and Alternatively
            Spliced Variant Forms of CDK5RAP2
  JOURNAL   PLoS One 10 (11), e0142577 (2015)
   PUBMED   26550838
  REMARK    GeneRIF: mouse expresses only one form of CDK5RAP2 that is
            equivalent to the human and rat alternatively spliced variant forms
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5564)
  AUTHORS   Mori,Y., Inoue,Y., Tanaka,S., Doda,S., Yamanaka,S., Fukuchi,H. and
            Terada,Y.
  TITLE     Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein,
            Binds to CDK5RAP2 and Regulates Microtubule Stability
  JOURNAL   PLoS One 10 (10), e0140968 (2015)
   PUBMED   26485573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5564)
  AUTHORS   Yigit,G., Brown,K.E., Kayserili,H., Pohl,E., Caliebe,A.,
            Zahnleiter,D., Rosser,E., Bogershausen,N., Uyguner,Z.O.,
            Altunoglu,U., Nurnberg,G., Nurnberg,P., Rauch,A., Li,Y., Thiel,C.T.
            and Wollnik,B.
  TITLE     Mutations in CDK5RAP2 cause Seckel syndrome
  JOURNAL   Mol Genet Genomic Med 3 (5), 467-480 (2015)
   PUBMED   26436113
REFERENCE   6  (bases 1 to 5564)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   7  (bases 1 to 5564)
  AUTHORS   Hassan,M.J., Khurshid,M., Azeem,Z., John,P., Ali,G., Chishti,M.S.
            and Ahmad,W.
  TITLE     Previously described sequence variant in CDK5RAP2 gene in a
            Pakistani family with autosomal recessive primary microcephaly
  JOURNAL   BMC Med Genet 8, 58 (2007)
   PUBMED   17764569
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5564)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 5564)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 5564)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_063287224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.156251.1,
                                           SRR26360181.1307425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               JAXUCZ010000005.1  88975683-88975909   c
            228-295             JAXUCZ010000005.1  88969093-88969160   c
            296-363             JAXUCZ010000005.1  88966558-88966625   c
            364-474             JAXUCZ010000005.1  88946102-88946212   c
            475-551             JAXUCZ010000005.1  88942797-88942873   c
            552-675             JAXUCZ010000005.1  88937564-88937687   c
            676-830             JAXUCZ010000005.1  88934516-88934670   c
            831-993             JAXUCZ010000005.1  88929034-88929196   c
            994-1035            JAXUCZ010000005.1  88927960-88928001   c
            1036-1155           JAXUCZ010000005.1  88927024-88927143   c
            1156-1248           JAXUCZ010000005.1  88924497-88924589   c
            1249-1467           JAXUCZ010000005.1  88919655-88919873   c
            1468-1638           JAXUCZ010000005.1  88901850-88902020   c
            1639-1779           JAXUCZ010000005.1  88897081-88897221   c
            1780-1877           JAXUCZ010000005.1  88888818-88888915   c
            1878-2002           JAXUCZ010000005.1  88883900-88884024   c
            2003-2112           JAXUCZ010000005.1  88882346-88882455   c
            2113-2241           JAXUCZ010000005.1  88880533-88880661   c
            2242-2426           JAXUCZ010000005.1  88871901-88872085   c
            2427-2859           JAXUCZ010000005.1  88863091-88863523   c
            2860-3091           JAXUCZ010000005.1  88858297-88858528   c
            3092-3223           JAXUCZ010000005.1  88855227-88855358   c
            3224-3797           JAXUCZ010000005.1  88849516-88850089   c
            3798-4030           JAXUCZ010000005.1  88847494-88847726   c
            4031-4079           JAXUCZ010000005.1  88840480-88840528   c
            4080-4258           JAXUCZ010000005.1  88837752-88837930   c
            4259-4378           JAXUCZ010000005.1  88833532-88833651   c
            4379-4495           JAXUCZ010000005.1  88830175-88830291   c
            4496-4685           JAXUCZ010000005.1  88827768-88827957   c
            4686-4810           JAXUCZ010000005.1  88826829-88826953   c
            4811-4888           JAXUCZ010000005.1  88823666-88823743   c
            4889-5154           JAXUCZ010000005.1  88822582-88822847   c
            5155-5298           JAXUCZ010000005.1  88819717-88819860   c
            5299-5425           JAXUCZ010000005.1  88812938-88813064   c
            5426-5472           JAXUCZ010000005.1  88807902-88807948   c
            5473-5564           JAXUCZ010000005.1  88807402-88807493   c
FEATURES             Location/Qualifiers
     source          1..5564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..5564
                     /gene="Cdk5rap2"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
     exon            1..227
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="Cdk5rap2"
                     /note="upstream in-frame stop codon"
     CDS             169..5529
                     /gene="Cdk5rap2"
                     /note="isoform 1 is encoded by transcript variant 1; CDK5
                     activator-binding protein C48"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2
                     isoform 1"
                     /protein_id="NP_001423547.1"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
                     /translation="MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVL
                     PIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKK
                     NIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELL
                     TKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEE
                     KDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEE
                     RQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEVEELN
                     SIIKELTADSTQSREAPLKTQVSEFEESENCEAALAEKEALLAKLHSENVTKNTENHR
                     LLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCERE
                     KAVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYLMT
                     AEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKTEQNVYAHLAKNLQ
                     DTDSKLQAELKRVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQTSY
                     LSICLEEHSQFQLEHFSQEEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQGND
                     RLESTKQAEIMEDYAEGGGKDGYVRHMDSNILDHDGAHTPDTSEDHSLEDELLSLLAT
                     FFSKKATPSLESRPDLLKALGALLLERICLAEQGSPGDHSDSKAEKALEQVAVRLRDE
                     LGHSCLANSFSKSHSELKSPRGTWLVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERK
                     REAWAGKPEEAVFSTELESEALGEMPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELL
                     ENLYNLPASQEVVAQLQGQVLELQKELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTP
                     VNVPAAQAVVRTAFQGKPGEQEGHETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLAL
                     LPACKENLEDFLGPPSIATYLDSKSQLSVKVSVVGTDQSENINLPDDTEALKQKIHDL
                     QTELEGYRNIIVQLQKHSQCSEAIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQV
                     RYVKHMKILRPLTPEIIDGKMLESLKQQLVEQEQELQKEQDLNLELFGEIHNLQNKFR
                     DLSPSRYDSLVQSQARELSLQRQQIKDSHDICVVCHQHMSTMIKAFEELLQASDVDSC
                     VAEGFREQLTQCAGLLEQLEKLFLHGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPE
                     SPEPSASHALSDDEMSEKSFLSREPKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRK
                     HLEESIKTNEKLRKQLERQGCETDQGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTM
                     LEKGSKEKQKENEKLRESLARKTESLEHLQLEYASVREENERLRRDISEKERQNQQLT
                     QEVCSSLQELSRVQEEAKSRQQLLLQKDELLQSLQMELKVYEKLAEEHQKLQQDVNKC
                     PEASDNSFDLFESTQAMAPKSASETPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRH
                     LWASKSGHHMLCLIEDYDALYKQISWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVP
                     LSKFLSSMNTAKLILEKASRLLKLFWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLF
                     EQEKKLQNTAKLLQQSKHQEKIIFDQLVITHQVLRKARGNLELRPRAAHPGTSSPSRP
                     GS"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    349..555
                     /gene="Cdk5rap2"
                     /note="Centrosomin N-terminal motif 1; Region: Cnn_1N;
                     pfam07989"
                     /db_xref="CDD:462333"
     misc_feature    604..>1533
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    604..>1533
                     /gene="Cdk5rap2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    4279..>4821
                     /gene="Cdk5rap2"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; Region: EnvC; COG4942"
                     /db_xref="CDD:443969"
     misc_feature    4279..>4821
                     /gene="Cdk5rap2"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; Region: EnvC; COG4942"
                     /db_xref="CDD:443969"
     exon            228..295
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..363
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..830
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..993
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1035
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1155
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1248
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1467
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1638
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1779
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1877
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2002
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2112
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2241
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2426
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2859
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3091
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3223
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3797
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..4030
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4079
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4258
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4378
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4495
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..4685
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4810
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4811..4888
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..5154
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5298
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5425
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5472
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5564
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccggga aagatggcgg cggctgcggt ttgaattcca gcggcgccgc ttgactgaga
       61 acaagagctg ggttggaggg ggcgggacct ggggaaccga gcgcgccgcg actgcggggt
      121 aaccagtggc gctgctgctg cagacaccgg tgccacctct ttgtgttcat gatggactca
      181 gggatggaag aggacgtcac cctgcctggg accctcagcg gctgcagtgg ccttcaccct
      241 gttctaccaa gtgatctgga tgtcatcagt gacactactg gcttgggaaa tggagtgctc
      301 ccaatcatgt cagaagaaaa ggtctctccc accagagccc ggaacatgaa ggactttgaa
      361 aaccaaatca ctgagctgaa gaaggagaac ttcaatctaa agctccggat ctacttcctt
      421 gaggagagga tacagcagga gtttgctggc cccacagagc acatctacaa gaagaacatt
      481 gaactcaagg tggaagtgga aagtctgaag cgtgagctcc aggagagaga tcagttgctc
      541 gtcaaagcct ccaaagccgt ggagagccta gcagaagggg gtggttctga aatccagcgg
      601 gtgaaagaag atgcaaggaa gaaggtgcag caggtggaag aactcctaac taaaaggata
      661 catcttctag aagaagatgt gaaagccgcc caagcagaac tggagaaggc ctttgcaggg
      721 acagaaacag agaaggctct tcggctcagc ttagaaagca agctctcggc gatgaagaag
      781 atgcaggagg gggacctgga gatgactctg gctctggaag agaaggacag actgattgag
      841 gagttgaagc tgtctttgaa gagcaaagaa gctttaattc agtgccttaa agaggaaaaa
      901 tctcagatgg catctcctga cgagaacgtg tcatctggag aactccgagg actttctgcc
      961 actctaagag aagaaaaaga gagagacgct gaggaacggc agaaggagag aaaccacttt
     1021 gaagagagga tccaggcact tcaggaggac ctgagagaga aggaaagaga aattgctaca
     1081 gagaagaaaa atagcttaaa gagggataaa gccattcagg gtctaaccat ggcattaaaa
     1141 tcaaaggaaa aagaggttga agaacttaat tccataatca aagaactcac tgctgactcc
     1201 acccaaagta gagaggctcc cttgaaaacc caggtctccg aattcgagga gtctgagaac
     1261 tgtgaggctg cgctggcaga gaaggaagcc ctgttggcca agctgcactc ggaaaatgtc
     1321 acaaagaata ctgagaacca taggttgctc aggaatgtta aaaaggtcac ccaggagttg
     1381 aatgacctga agaaggagaa gctgagacta gagcgggacc tggaggaagc ccaccgagaa
     1441 gggaacagag gagcccgaac catccatgac cttagaaatg aagttgagaa actacgcaag
     1501 gaagtgtgtg agagagagaa ggctgtggag aagcattaca agagtcttcc aggcgaaagc
     1561 agttcaaagt tccattctca agaacaagtg gtcaaaggtc tgacagaaag tgccagtcag
     1621 gaggacctgc tgctgcagaa atccaatgaa aaagatttgg aagcaataca gcagaactgt
     1681 tatttaatga ctgcagagga gctcaagttt gggagcgatg gcttaataac agaaaagtgt
     1741 tctcagcagt caccagacag caaactcatc ttctccaagg aaaagcaaca atcagagtat
     1801 gaagggctga ctggggactt aaagacagaa cagaacgtct atgcccatct ggcaaagaat
     1861 ctgcaggaca cagacagcaa actgcaggct gaattgaaaa gggttcttgc cctccggaag
     1921 cagctggagc aggatgtgct tgcctatcgg aatctgcaga cggccctgca ggagcagctc
     1981 agtgaaattc ggaagcggga agaagagccg ttttcatttt atagcgatca aacatcatat
     2041 ctaagtattt gccttgaaga gcacagtcag tttcaattgg agcatttttc tcaagaagaa
     2101 atcaagaaaa aggtcattga cctcatacag cttgtgaagg acctgcatgc agacaaccag
     2161 cacctgaaga aaaccatttt tgatatctct tgcatgggtg tccagggaaa tgacagactt
     2221 gagtcaacaa aacaagcaga gatcatggag gactatgctg agggtggcgg caaggatgga
     2281 tatgtaaggc acatggattc caatatttta gaccatgatg gggcccacac acctgatacc
     2341 tctgaagacc atagcctaga ggatgagctc ctgagcctac tcgccacttt cttcagtaag
     2401 aaggctacac cgtcgctgga gtccaggccg gatctgctga aagcacttgg tgccctgctt
     2461 ttggaacgga tatgcttggc agaacaggga agtcctggag atcactctga tagtaaagct
     2521 gagaaggcac ttgagcaagt agctgttcgg ttgagagatg aacttggcca ttcctgccta
     2581 gccaactcat tctccaagtc acacagtgag ctcaagtcac cgcggggcac ctggctagta
     2641 aagacaggtg atgaagccaa ggtggagctg aagagtgtct cagtgcagac catgaccata
     2701 gaggacagca cccgtggatt caaacctgag aggaagagag aagcttgggc agggaaacca
     2761 gaagaggccg ttttcagcac tgagcttgag tcagaggcgt tgggtgagat gccagggcta
     2821 caggccactc acctctcatt ccccagtgcc atcgacaagg atgaccagaa gacaggcttg
     2881 ctgatccaat taaaaacacc tgagttattg gaaaatttgt ataatcttcc tgcctcccaa
     2941 gaggtggtag ctcaactcca gggccaggtt ctagagctgc agaaagagct gaaagagtat
     3001 aagatccgca acaagcaact ccttgataag ctaattctgg cagaggcaat gatggagggg
     3061 atggcagtgc ccaactctac tccggtaaac gtgcctgcag cccaggctgt tgtgagaaca
     3121 gccttccaag gcaagccagg cgagcaagaa ggacatgaaa ccacacattc tgccggaaga
     3181 gacaaggaag tagacagtga ccaatataca agctttgaga ttgattctga aatctgccca
     3241 cctgatgacc ttgccttatt accagcatgc aaagagaacc ttgaagactt cttaggccca
     3301 ccctccatag ccacttacct ggattccaag agtcagctct ctgttaaagt cagtgtggtt
     3361 ggaactgacc agtctgagaa tatcaatctc cctgatgata cagaagcctt aaaacagaaa
     3421 atccatgact tgcaaactga gctggaaggc taccggaaca tcattgtcca gctacagaag
     3481 cattctcagt gcagtgaggc tattattaca gttttgtgtg ggacagaagg ggcccaagat
     3541 ggcctgaaca agcctaaggg ccacatcgat gaagaagaga tgacattttc aagtttgcac
     3601 caagtaagat atgtgaagca catgaaaatc ctccgtccac taaccccaga aataattgat
     3661 ggcaagatgc tagagagcct caagcagcag ctggtagaac aggagcagga gctacagaag
     3721 gagcaggatt tgaacttgga acttttcggt gaaatccata acctgcagaa caagttccga
     3781 gacctctcgc catcaagata cgattcattg gttcagtccc aagcaaggga gctctctctt
     3841 cagcggcagc aaattaagga tagtcatgat atctgtgtcg tttgccatca acacatgagc
     3901 accatgatca aggcatttga ggaacttctg caggccagtg atgtggacag ttgtgtggct
     3961 gagggcttcc gcgagcagct aacacagtgt gctggactgc tagagcaact ggagaagctg
     4021 tttctccatg gaaagtcagc cagagtggaa ccacataccc agactgaact gctaaggagg
     4081 ttaagaactg aagaagacaa cttaccttac caacatctcc tgcctgaatc tcctgagcct
     4141 tctgcctctc atgctctgtc agatgatgaa atgtctgaga agtccttcct gtccagagaa
     4201 ccgaagccag acagtgagac tgagaagtac ccaacaatag cgagccgttt tcctcaagac
     4261 ttactaatgg aacacataca ggaaattcga actttgagaa agcatttgga agaatctatt
     4321 aaaacaaatg agaagctccg gaaacagctg gaacggcagg gatgtgagac tgaccaaggc
     4381 tctacaaatg tttctgctta cagctcagaa ctgcataatt ctctgacatc agaaatacag
     4441 ttcctgagga agcagaatga ggccctcagt acgatgctcg agaaggggtc caaagaaaaa
     4501 cagaaagaga atgaaaaatt gcgtgagtcc ctggccagga agactgagag tcttgagcac
     4561 cttcagctag agtatgccag tgtaagggaa gaaaatgaaa gactgcggag agacatcagt
     4621 gagaaggaga gacaaaacca gcagttgact caggaggtct gcagcagcct ccaagagctg
     4681 agcagggtac aggaagaggc aaagtcaaga cagcagctgc tcttacagaa agacgagctg
     4741 cttcagtccc tccaaatgga gcttaaggtg tatgagaagc tggccgagga gcatcagaag
     4801 ctacagcaag atgtcaacaa atgtcctgag gccagcgata attcatttga tctatttgaa
     4861 tctacccagg caatggcacc taaatcagct tctgagactc ctgtcctttc tggaactgat
     4921 gttgattccc tctcctgtga cagtaccagt tctgccacca gcccctcttg catgccctgc
     4981 ctggttgctg gccgccacct gtgggccagc aagagtggcc accacatgct gtgcctgatt
     5041 gaggactatg atgccctcta taagcagatc agctggggcc agacactgct tgccaagatg
     5101 gatattcaaa cccaagaggc tctgagcccc acaagtcaga agctgggacc aaaggcttca
     5161 ttctctgtgc ctctgagcaa gtttctctcc agcatgaaca cagccaagct gatcctggaa
     5221 aaagcctcca ggttgctgaa gctcttctgg agggtctctg tccccaccaa cggccagtgt
     5281 tcccttcact gtgaccagat tggagaaatg aaggcagaga tcaccaaact acacaaaaaa
     5341 ttgtttgaac aagaaaagaa gctgcagaac acagcaaaac ttctgcagca gagcaagcac
     5401 caggagaaaa tcatctttga tcagttggtc atcacccacc aagtccttcg gaaagccagg
     5461 ggaaacctgg agctcaggcc tagagctgcc catccaggaa catccagtcc cagcagaccg
     5521 ggctcatgag aagagctttc agctaataaa gcttgtgatc ctga
//
LOCUS       NM_001105912            2605 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus sorting nexin 8 (Snx8), mRNA.
ACCESSION   NM_001105912 XM_001065004 XM_006248920 XM_221947
VERSION     NM_001105912.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   van Weering,J.R., Sessions,R.B., Traer,C.J., Kloer,D.P.,
            Bhatia,V.K., Stamou,D., Carlsson,S.R., Hurley,J.H. and Cullen,P.J.
  TITLE     Molecular basis for SNX-BAR-mediated assembly of distinct endosomal
            sorting tubules
  JOURNAL   EMBO J 31 (23), 4466-4480 (2012)
   PUBMED   23085988
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Dyve,A.B., Bergan,J., Utskarpen,A. and Sandvig,K.
  TITLE     Sorting nexin 8 regulates endosome-to-Golgi transport
  JOURNAL   Biochem Biophys Res Commun 390 (1), 109-114 (2009)
   PUBMED   19782049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 13, 2025 this sequence version replaced
            XM_006248920.5, NM_001105912.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.45737.1,
                                           SRR26643285.56527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000012.1  19365763-19365876
            115-305             JAXUCZ010000012.1  19392571-19392761
            306-423             JAXUCZ010000012.1  19395231-19395348
            424-545             JAXUCZ010000012.1  19397141-19397262
            546-626             JAXUCZ010000012.1  19399999-19400079
            627-787             JAXUCZ010000012.1  19400328-19400488
            788-920             JAXUCZ010000012.1  19401248-19401380
            921-989             JAXUCZ010000012.1  19407792-19407860
            990-1136            JAXUCZ010000012.1  19409469-19409615
            1137-1286           JAXUCZ010000012.1  19409878-19410027
            1287-2605           JAXUCZ010000012.1  19413020-19414338
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2605
                     /gene="Snx8"
                     /note="sorting nexin 8"
                     /db_xref="GeneID:288504"
                     /db_xref="RGD:1305791"
     exon            1..114
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1400
                     /gene="Snx8"
                     /codon_start=1
                     /product="sorting nexin-8"
                     /protein_id="NP_001099382.2"
                     /db_xref="GeneID:288504"
                     /db_xref="RGD:1305791"
                     /translation="MTGRAMDPLPSPAVAAAAEAEADEEADPPATGPQTSQVTEWRNL
                     DPRRMQMPQGNPLLLSYTLQELLAKDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVY
                     RRYNDFVVFHEVLLHKFPYRMVPALPPKRVLGADREFIEGRRRALKRFINLVARHPPF
                     SEDVLLKLFLSFSGSDVQHKLKEAAQCVGDEFTNCKLAARAKDFLPADIQTQFAMSRE
                     LIRNVYNSFYKLRDRAERIASRAIDNAADLLIFGKELSALGSDTTPLPSWAALHLSTW
                     GSLKQALKGLSVEFALLADKAAQQGKKEENDVVEKLNLFLDLLQSYKDLCERHEKGVL
                     HKHQRALHKYGLMKRQMMSAAHGREPESVEQLESRIVEQENVIQTMELRNYFSLYCLH
                     QETQLVHVYLPLTSHILGAFVNSQIQGHKEMSKVWNDLKPKLSCLFAGPHSVLTPPRS
                     PQEDGMCPH"
     misc_feature    228..539
                     /gene="Snx8"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 8 and yeast Mvp1p; Region:
                     PX_SNX8_Mvp1p_like; cd06866"
                     /db_xref="CDD:132776"
     misc_feature    228..539
                     /gene="Snx8"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 8 and yeast Mvp1p; Region:
                     PX_SNX8_Mvp1p_like; cd06866"
                     /db_xref="CDD:132776"
     misc_feature    order(330..338,408..413,447..449)
                     /gene="Snx8"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132776"
     misc_feature    order(330..338,408..413,447..449)
                     /gene="Snx8"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132776"
     misc_feature    588..1322
                     /gene="Snx8"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 8; Region: BAR_SNX8; cd07597"
                     /db_xref="CDD:153281"
     misc_feature    588..1322
                     /gene="Snx8"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 8; Region: BAR_SNX8; cd07597"
                     /db_xref="CDD:153281"
     misc_feature    order(654..656,663..668,678..680,684..689,696..701,
                     705..710,759..764,768..773,780..785,789..794,801..803,
                     888..890,897..902,1203..1205,1212..1217,1221..1223,
                     1236..1238,1245..1250,1254..1259,1266..1271,1278..1283,
                     1287..1292,1299..1304,1308..1313)
                     /gene="Snx8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153281"
     misc_feature    order(654..656,663..668,678..680,684..689,696..701,
                     705..710,759..764,768..773,780..785,789..794,801..803,
                     888..890,897..902,1203..1205,1212..1217,1221..1223,
                     1236..1238,1245..1250,1254..1259,1266..1271,1278..1283,
                     1287..1292,1299..1304,1308..1313)
                     /gene="Snx8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153281"
     misc_feature    order(654..656,663..668,678..680,684..689,696..698,
                     705..710,759..764,768..773,780..782,789..794,801..803,
                     888..890,1203..1205,1212..1217,1221..1223,1236..1238,
                     1245..1250,1254..1262,1266..1271,1278..1283,1287..1292,
                     1302..1304,1308..1313)
                     /gene="Snx8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153281"
     misc_feature    order(654..656,663..668,678..680,684..689,696..698,
                     705..710,759..764,768..773,780..782,789..794,801..803,
                     888..890,1203..1205,1212..1217,1221..1223,1236..1238,
                     1245..1250,1254..1262,1266..1271,1278..1283,1287..1292,
                     1302..1304,1308..1313)
                     /gene="Snx8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153281"
     exon            115..305
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            306..423
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            424..545
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            546..626
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            627..787
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            788..920
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            921..989
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1136
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1286
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..2605
                     /gene="Snx8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgggcga gcgggctcac atgactggcc gcgcgatgga cccgctgccc tcgccggcag
       61 tcgctgcagc agctgaggcg gaggctgacg aggaggcgga tccgccggcg acaggcccac
      121 aaacatccca ggtcaccgag tggaggaacc tggaccccag gcgaatgcag atgcctcagg
      181 ggaatccgtt gctgctgtcc tacaccctgc aggagctgct ggccaaggac acggtgcagg
      241 tggagctcat ccctgagaag aagggcctgt tccttaagca tgtggagtac gaggtttcca
      301 gccagcgctt caagtcctcc gtgtacagac gctacaatga cttcgtggtc ttccatgaag
      361 tgctgcttca caagttcccg taccgcatgg taccagccct tccacccaag agagtgctgg
      421 gagccgaccg ggagttcatc gagggccgcc ggagggccct gaagcgcttc atcaacctgg
      481 tggcccggca cccgcccttc tctgaggatg tgctcctgaa gctcttcctc tccttcagtg
      541 gctcagatgt tcagcacaag ctcaaggagg cggcccagtg cgtgggagat gagttcacga
      601 actgtaagct ggctgctagg gccaaggact tcctcccagc tgacatccag actcaatttg
      661 ccatgagccg ggagctgatt cgaaatgtct acaacagctt ctacaaactt cgagacagag
      721 ccgagcggat tgcgtcccgg gccattgaca acgctgctga tcttctcata ttcgggaagg
      781 agctcagtgc tttgggttcc gacaccaccc ctctgccctc ctgggctgct ctgcacctca
      841 gcacgtgggg ctccctgaag caagcgctca agggcctgtc cgtggagttt gctttgcttg
      901 cagacaaagc tgcacagcag ggtaagaagg aggagaatga tgtggtggag aagctgaacc
      961 tcttcttgga tttgctgcag tcctacaaag acctgtgtga gcggcatgag aagggcgtgc
     1021 ttcacaagca tcagcgagca ctgcacaagt acggcctgat gaagaggcag atgatgagtg
     1081 cggcacatgg ccgagagccc gagtctgtgg agcagctgga gtcacgaatt gtggagcagg
     1141 agaacgtgat ccagactatg gaactccgaa actacttctc cctgtactgt ctgcaccagg
     1201 agactcagct tgtccatgtc tacctgcctc tcacctctca catcctgggg gccttcgtga
     1261 actcccagat ccaagggcac aaggagatga gcaaggtgtg gaatgacctg aagccaaagc
     1321 tgagctgcct ctttgctgga cctcacagtg tgctgacacc accacgctcc ccgcaggagg
     1381 atggcatgtg tccccactag tgacaaggcc cacgacagag ctccctgtgg cctcactaaa
     1441 acctctttgc aaacagtgtg tccctggctg attccctcta ggcagcagcc attcccccga
     1501 gctgcctgtg ggctgtgctg gccatctttg tgtctccctg ttcctgggca ggaggtcttc
     1561 gtgcccccag cccgcccctt ggcctgtttc tcaggtcggt agtgggaaac gagggtgctt
     1621 tggactggat tgtgcccgat gcccagtgct aagggccttt tgtacccagt aagtggcatc
     1681 taggggagcc taggggttaa cctagcagca aagaaatggg aggactggcc ctgtccggtg
     1741 tggcctggca aggagctggt caatctctga ggaacccaag tacactaggc ctgcagacat
     1801 tcttcgaggg gtattcaagg ccaggcgagt ggtctcacac aggaggaggg gttgagtgtg
     1861 cagtgtgtgg agcttaggag gacatattgc actccagtac gatccttcga ggtccagggc
     1921 ctgtcagggt ccaatggatg agtttcctgt gttgagtgag gaagggttgt tggggcactg
     1981 gagatgggca tccctgttgg gctgtccgtc agcaggctct gcgtggacga gagttgtttc
     2041 ctctgccggc cgctcactgg ctgtgcgctg caggcctgtg gccctcaaag ctggcgtaga
     2101 gcctgccttt tctcatgcag tctttccctg actgggctgt aggtgcccga ctccaaactt
     2161 gaggttcctc tccagggttc aaaggaatgc agagtccctg tacccttctg ggcatcctgc
     2221 tgtccgagcc tgtgctgcac cacagccatg cttggggctg ctagaaagac ggagaagcac
     2281 aagtatcacc ggatctcccg cctgcctgtc ccttttcctg ggctgggtgg ggcccagctg
     2341 tagccttaac tggacggtcc tggggccatc agagtaagag tgaagggaag agcttttttt
     2401 tttttttttt tttttttttg atgccactct gactgaagaa gctgacagca ggggcagagg
     2461 ggctctggga cactgctgtg tggactctgg gttaagggcg tgaagaggct ggtgctgtgg
     2521 gattcggctc gatgaatgaa gcactttatg gactgcggga atcagttact gccacaccca
     2581 ataaactgga agtgtttaca gatgg
//
LOCUS       NM_001436514            6354 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 38
            (Zbtb38), transcript variant 1, mRNA.
ACCESSION   NM_001436514 XM_063265576
VERSION     NM_001436514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6354)
  AUTHORS   Miotto,B., Chibi,M., Xie,P., Koundrioukoff,S., Moolman-Smook,H.,
            Pugh,D., Debatisse,M., He,F., Zhang,L. and Defossez,P.A.
  TITLE     The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common
            fragile site stability
  JOURNAL   Cell Rep 7 (2), 575-587 (2014)
   PUBMED   24726359
REFERENCE   2  (bases 1 to 6354)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   3  (bases 1 to 6354)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 6354)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
REFERENCE   5  (bases 1 to 6354)
  AUTHORS   Kiefer,H., Chatail-Hermitte,F., Ravassard,P., Bayard,E., Brunet,I.
            and Mallet,J.
  TITLE     ZENON, a novel POZ Kruppel-like DNA binding protein associated with
            differentiation and/or survival of late postmitotic neurons
  JOURNAL   Mol Cell Biol 25 (5), 1713-1729 (2005)
   PUBMED   15713629
  REMARK    GeneRIF: ZENON is involved in the maintenance of panneuronal
            features and/or in the survival of mature neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 13, 2025 this sequence version replaced XM_063265576.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1342618.1,
                                           SRR26643287.20999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000008.1  106196835-106196891 c
            58-161              JAXUCZ010000008.1  106195399-106195502 c
            162-6354            JAXUCZ010000008.1  106161802-106167994 c
FEATURES             Location/Qualifiers
     source          1..6354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..6354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
     exon            1..57
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     exon            58..161
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    138..140
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="upstream in-frame stop codon"
     exon            162..6354
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3773
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="zenon; zinc finger protein expressed in neurons;
                     zinc finger transcription factor Kaiso"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001423443.1"
                     /db_xref="GeneID:315936"
                     /db_xref="RGD:1310136"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQE
                     TVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTN
                     GPRITNAFSIIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTL
                     AEHSYAVSSITEAYRSQPLREHDSSSSSGKTGKENGEALTTKAKPCRKPKTQTQDSDS
                     TTENMPLPLVTCPEVNQERSPQPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAA
                     EVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQIC
                     MRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRIGELSSAGSALSDADHMV
                     KFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIW
                     HTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYR
                     LLPMRCKRAPYKSYRNSSYESAQGNRQRNESPPDTFVIPNLPSSEMPTLNFQDGRNSL
                     TSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQALKTDLVDSAEVSISSIGNSVSTTL
                     QAEPVCVSSGEHSASVISYSGSVPSVIVHSSQFSSVIKHSNAIACLANSNHQSPSQPV
                     ASPSLIKDSKPEADKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLGGSSGKTT
                     NVVEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGR
                     KPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNY
                     KPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELDRCAEVKL
                     PPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHLTLKPYICELCAKQFQSSS
                     TLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETL
                     KIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKICKTAAA
                     LRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDSEDSDQKDDIKKPLLKMSFE"
     misc_feature    204..545
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    204..545
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 38 (ZBTB38); Region:
                     BTB_POZ_ZBTB38_CIBZ; cd18223"
                     /db_xref="CDD:349532"
     misc_feature    549..551
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3; propagated from
                     UniProtKB/Swiss-Prot (Q5EXX3.1); phosphorylation site"
     misc_feature    849..1163
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1056..1727
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Interaction with CBFA2T3.
                     /evidence=ECO:0000250|UniProtKB:Q8NAP3"
     misc_feature    1083..1364
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1083..1364
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2-type zinc ribbon; Region: zf-C2H2_8;
                     pfam15909"
                     /db_xref="CDD:464935"
     misc_feature    1188..1250
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1188..1250
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1188..1190,1197..1199,1236..1238,1248..1250)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1188..1190,1197..1199,1236..1238,1248..1250)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1275..1334
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1275..1334
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1542..1604
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1542..1604
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1542..1544,1551..1553,1590..1592,1602..1604)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1542..1544,1551..1553,1590..1592,1602..1604)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1557..1559,1563..1565,1569..1571,1575..1580,
                     1587..1592,1599..1601,1641..1643,1647..1649,1659..1664,
                     1671..1676,1683..1685,1725..1727,1731..1733,1737..1739,
                     1743..1748,1755..1760)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1557..1559,1563..1565,1569..1571,1575..1580,
                     1587..1592,1599..1601,1641..1643,1647..1649,1659..1664,
                     1671..1676,1683..1685,1725..1727,1731..1733,1737..1739,
                     1743..1748,1755..1760)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1626..1688
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1626..1688
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1710..1766
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1710..1766
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1902..2093
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2352..2489
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2730..2807
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2844..2903
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3216..3278
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3216..3278
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3216..3218,3225..3227,3264..3266,3276..3278)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3216..3218,3225..3227,3264..3266,3276..3278)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3231..3233,3237..3239,3243..3245,3249..3254,
                     3261..3266,3273..3275,3315..3317,3321..3323,3333..3338,
                     3345..3350,3357..3359,3399..3401,3405..3407,3411..3413,
                     3417..3422,3429..3434,3441..3443)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3231..3233,3237..3239,3243..3245,3249..3254,
                     3261..3266,3273..3275,3315..3317,3321..3323,3333..3338,
                     3345..3350,3357..3359,3399..3401,3405..3407,3411..3413,
                     3417..3422,3429..3434,3441..3443)
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3255..3326
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3255..3326
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3294..3362
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3294..3362
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    3300..3362
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3300..3362
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3384..3446
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3384..3446
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3423..>3479
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3423..>3479
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    3468..3530
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3468..3530
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3561..3623
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3561..3623
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3675..3770
                     /gene="Zbtb38"
                     /gene_synonym="RGD1310136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EXX3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 aggtccggaa gcgccatgga ccccgcggga agcgcgcggg cggcggagcg gagccccatc
       61 ttgctgtgga agacatggag ggcccagaac caaggatttc caagtgattt ctgccaaagc
      121 acagaagcta actctgttaa ggctggcatg ttctaactga gatgacagtc atgtccctct
      181 ccagggacct caaggacgac tttcacagtg acacggtgct ctccatccta aatgagcagc
      241 gcattcgggg catcttatgt gatgtcacca tcattgtgga ggacaccaag tttaaagccc
      301 acagcaatgt cctggccgcc tcaagccttt atttcaaaaa catcttttgg agccatacga
      361 tctgtatttc cagtcatgtc ctagagctgg atgatctgaa agccgaagtg tttacagaga
      421 ttcttaatta catctacagc tccaccgtgg tggtcaggag acaggaaacc gtcactgacc
      481 ttgcagctgc agggaaaagg ctgggaatat cattcttaga ggaccttagt gaccgcaact
      541 tctcaaattc cccaggtcct tacgtagttt gcatcactga aaagggcgtg gttaaagaag
      601 aaaaaaatga aaaaaggcac gaagagccag ctgtcactaa tgggcccagg atcacaaacg
      661 cattttccat cattgagacg gaaaatagca atagcatgtt ttctcccctg gacttgaggg
      721 caagcttcaa aaaagtgtca gatgccatga gaaccactag cctttgccag gagagagcca
      781 gtgtctgccc cgaggcagag cctgtccgca cgcttgccga acactcatat gccgtttctt
      841 ccatcactga ggcctacagg agtcagcctc tgagggaaca tgacagcagc agttcatctg
      901 gtaaaacggg aaaagaaaat ggcgaagctc tcaccacaaa agcaaagcca tgccgaaagc
      961 caaagaccca aacccaggat tctgactcaa ccacagagaa catgccactc cctctagtaa
     1021 cctgcccaga ggtgaatcaa gaaagaagcc cacagccagc tccaattctg tcacactcag
     1081 aacctcccag cagtgaagga gatgtccatt ttcccagaga agatgaaaac cagccctctg
     1141 agactcctgg tcccccagca gcagaggtcc cgcccctcgt ttataattgt agctgctgct
     1201 ccaaatcctt cgacagcagc acactgctcg gggcccacat gcagctgcac aagccgacgc
     1261 aggacccctt tgtgtgcaag tactgcaaca agcagttcac caccctcaac aggctggacc
     1321 ggcacgagca gatctgcatg aggtcgagcc acatgcccat gccaggagga aaccaaccct
     1381 tcttagaaaa ctaccccacc attggacaag atggaggttc attcacaagc ccagattcat
     1441 tggtgccaga aagtaggatt ggtgaactat ccagcgctgg gagtgccttg tcagacgcgg
     1501 accacatggt gaaatttgtg aatgggcaga tgctttacag ctgcgttgtg tgcaaacgta
     1561 gctatgtgac tttgtccagc ctccggaggc acgcaaatgt ccactcgtgg agaagaacgt
     1621 acccttgtca ttactgcaac aaggtcttcg cactggctga gtacaggaca cgacatgaga
     1681 tctggcacac tggagagagg cggtaccagt gcattttctg tcttgaaacg tttatgacct
     1741 actacatact gaaaaaccat cagaagtctt ttcatgccat agatcacaga ctctccatca
     1801 gtaaaaaaac agcaaatgga ggcttgaagc ccaccgtcta cccatacaaa ctttacaggc
     1861 tcttgcctat gagatgcaag cgggcacctt ataagagcta ccggaattct tcctatgaaa
     1921 gtgctcaagg aaaccgtcaa aggaatgaat ccccacctga caccttcgtc attccgaatc
     1981 tgccaagctc tgaaatgccc acactgaact tccaagatgg cagaaactcg ttgaccagca
     2041 gccctgccat cccagtggaa acaccttcat ggcagggtac acccacttct gccaaagtaa
     2101 aaaatgcaga aggcctcaaa tggaggaagc aggcactgaa aaccgatctc gtcgattcgg
     2161 ctgaggtgtc gatttcttcc attggaaact ctgtcagcac caccctgcag gcagagcccg
     2221 tgtgtgtttc gagtggggag cactcggcct ccgtgatcag ctacagcggc tcggtgccct
     2281 ctgtcattgt gcacagcagc cagttctcgt cggtgatcaa gcacagcaat gccattgcct
     2341 gcctggccaa cagcaaccac cagtcccctt cacagcctgt ggcgagtccg tccctgatca
     2401 aggatagcaa gcctgaggca gataaagcca gtaaactcgc aagcagaccc aaaaactcta
     2461 aggagaaaaa gaaaaccgtt ccatgtaaca ggggagaaat aacagaggag gcaaaatatg
     2521 ttgctgatct cggaggatct tcgggcaaaa ccacaaatgt cgtcgaagaa accagtaaga
     2581 ttgaaactta tatagcaaaa cccgctctgc ccggcacctc cacaaatagc aatgttgcac
     2641 ccctttgcca aataacagtg aaaattggga acgaagccat cgtgaaaagg catatccttg
     2701 ggtctaagct gttttacaaa agagggagaa aacccaagta tcaaatgcag gaagagacat
     2761 tgcctcggga gagtgacccc gaaacccgtg gagacagccc tcttgggctc tgccaagctg
     2821 actgtgtgga gatgagtgaa gcatttgatg aagtgagtga ccaggactcc accgataagc
     2881 cgtggcgccc atactacaac tacaagccca agaagaaatc caaacagtta agaaaaataa
     2941 ggaaagtcaa gtggaggaag gaacgaggga gcagaagccc cgtgggtcgg cgcaggtatc
     3001 cagctgagct ggatcgcgca gagatgggtc ggcgcaggta cccagctgaa ctagatcgct
     3061 gcgcagaggt gaaattgccc ccagataagg cctctgaaga agaggagaat aaagagatgc
     3121 ccaagctgca gtgcgagctc tgtgacggtg acaaagcagc aggggcggga gccgaaggca
     3181 agccccacca gcatctcact ctgaagcctt acatctgcga gctctgtgcg aagcagttcc
     3241 agagctcctc cacgctcaag atgcacatga gatgccacac tggcgagaag ccctaccagt
     3301 gcaagacctg tgggcggcgc ttctcagtgc agggcaacct acagaagcac gagcgcattc
     3361 acctgggcgt gaaggagttc atctgtcagt attgtaacaa ggctttcacg ctgaacgaga
     3421 cactcaagat ccacgaaaga atccacacag gggagaagcg ttaccactgt cagttctgct
     3481 ttcagggttt cttatatctc tccacaaaaa ggaaccacga gcggaggcat gtccgggagc
     3541 atgacgggaa aggctttgct tgcttccagt gccccaaaat atgcaaaaca gctgctgccc
     3601 tcagaatgca ccaaaagaag cacttattca agaccttgac taagcaagag gaaacagatg
     3661 acctttgcca cgaaaactcc gatctcttgg agagtcaacc ttgcactgat tcggaagaca
     3721 gcgaccaaaa ggatgacata aaaaaacctt tgctgaaaat gtcctttgag tgacaacagt
     3781 tagaaaggtc ttcaaaattg tttgtgattt tttttatttt tagtttttta agttttttta
     3841 agcttagttt tgttcacata atattctcaa aggatggggg gttgttaatt ttcctttgtg
     3901 taaactcccc ccaaaaagga tcctaacaac tattttgggt tttatcattc actctacaca
     3961 gaatgcataa aaacaaacta gctgaatcct ctaacgaccg agtattttgt gaaggctaat
     4021 gaagttctga gctgtgggat tttgaacagt ggaaagagca gctggatttt agcctaattt
     4081 aagcctttct ctcgcgcact aatgaggtct gctgaactgt tgttagtcac tggagagagt
     4141 aagggtcagg atcgtgcaga tggcatcttt gagacatgct aaacgagcta tgacagtatt
     4201 tattgccatt gagtttctgc actattaatc tttggtaaac tgatgggtat ttacaaaata
     4261 tctaacaata taactgaaca tatgtaatgg gtaacctaaa gtaggacatt ctcatatcac
     4321 ctagagacac ttttctgcag cataaacctt gtaaagtacg tatatgaatc actataacgt
     4381 ttagctgtct gtctgtccct agtagagaac cacaagagca atagacctca gataacacgg
     4441 actgctgtag aaatcagtag aacatttgga atctggctga cgagcatgtg tgtgcttctc
     4501 gatggagtgc tgtgctgttc tcctgaagta tggctgagct gttagttgaa ctggtccact
     4561 caagtcacac agaacatagg tcatgcctta tctatgagaa aaccttccta gacttacctg
     4621 agattaccta tgccacacag tcctctgcag tggcctcacc tcagaatgaa gaatgatcac
     4681 attcttcaga actctgcagt cttccagtca tcccaaggcc atggatgttg gggggctatc
     4741 ccacccaact tctgtggtca aataatcctg gtccctccca ttccactgaa gcagcagctg
     4801 gaggctgagg gagagacaca cctctgtggt aatcaatctc agtcccttgg aaaggccgaa
     4861 agcctgattc ctcaggttta catctccttg gagctaatgc agcacacagg tacatagtag
     4921 tgaaaagggc cacagactcc ttacccccac tgataacatg aggacagggg gacctgatgc
     4981 ctccaacagc agcattgttt ttgagggatg gggagataga atgtggaatg acagtgttct
     5041 gccccttaca aacatgactc gaaacaccca caaagccaga tgcccctcct tcgtgttcgc
     5101 agacattagc tctctgttaa agccccactt ttacttctaa atccttctaa atattgactc
     5161 agactgtcaa cattgccctc aaaagtctcc ttgccctaca ggtatttttt catgggaact
     5221 agggtcctgg aaagctggaa ctcaaaagat tcttactgtt aacactggca gaataggagg
     5281 gagggagaac acagcctacc cttccagcac cagaatgggc aaaactcaga acaggttaag
     5341 tagtcgttcc cgctcgttgg attgagtagg tggaaagcca aggctggaag gttatcagag
     5401 gactctggtt tctcccaccc agtgttgtgt tgcctccacg aagaaggctt agcatggttt
     5461 ggggtaggca acatttaaac acccagaaaa aaggacatga ttcaaggtga cctttatact
     5521 gtagcacttt gctgttaccc ccaatatgta tctgcatttg tcatttgttc atctcccttt
     5581 acctacatac agtattatat agaggacatg gggaaacgca agcaattgaa ctttgttttg
     5641 tccattgtat atatgtgcac ccacaccatt tgagttttat tgaagtagtc acaaagggct
     5701 tatgaaaatc acttttgaat taataaccag atgacaagca atcctgtgat ccactaatat
     5761 gttttatctc agttatgatt ataaaacaat tatggattta agttgttttg atttaactac
     5821 aaataaagtt atatgtattg atgtctccca tcaatatgtg gatatttttt aagtggactt
     5881 gtatgctgat aattctagac caaagtaaat atggcagaat atttatacat acaaataatt
     5941 ttgcaaatat tttctataat tgtattattc atttaaaatg ttgatagctt gtgttagttt
     6001 cagggagggg gtgtatattt tgataaaata cttgactttg taattctgta tattctatac
     6061 aatttatagc agagccattt taagacaact ggttacattt ttttgttgat tgtgtaaatg
     6121 ttatgagtgg tgtttaagta tgcatcaagt acataatgac caagtagaat taaagtgtaa
     6181 acagtgaaca tactgtatgc tgtaaagata tattgtaact tgctgttttt agcatctgta
     6241 ttttggttag gaaatatgat taaatgcaga tgttaagggt tggaaaggtc taattttatt
     6301 tttagaaata atgaatataa atttgttttg cttgattaaa atagctcatt ccta
//
LOCUS       NM_001436533            2933 bp    mRNA    linear   ROD 20-MAR-2025
DEFINITION  Rattus norvegicus cysteine and serine rich nuclear protein 1
            (Csrnp1), transcript variant 1, mRNA.
ACCESSION   NM_001436533 XM_006244121
VERSION     NM_001436533.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2933)
  AUTHORS   Ye,X., Lin,J., Lin,Z., Xue,A., Li,L., Zhao,Z., Liu,L., Shen,Y. and
            Cong,B.
  TITLE     Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes
            apoptosis through activating Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 359 (2), 441-448 (2017)
   PUBMED   28830684
  REMARK    GeneRIF: Axud1 mediated stress-induced cardiomyocytes apoptosis
            through activating Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 2933)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2933)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 14, 2025 this sequence version replaced XM_006244121.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.35941.1,
                                           SRR26643284.11898.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680412,
                                           SAMN06680413 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000008.1  128589244-128589373 c
            131-366             JAXUCZ010000008.1  128588091-128588326 c
            367-626             JAXUCZ010000008.1  128585270-128585529 c
            627-941             JAXUCZ010000008.1  128584548-128584862 c
            942-2933            JAXUCZ010000008.1  128582364-128584355 c
FEATURES             Location/Qualifiers
     source          1..2933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2933
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="cysteine and serine rich nuclear protein 1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
     exon            1..130
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    60..62
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="upstream in-frame stop codon"
     exon            131..366
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1916
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="AXIN1 up-regulated 1"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1"
                     /protein_id="NP_001423462.1"
                     /db_xref="GeneID:363165"
                     /db_xref="RGD:1305999"
                     /translation="MAGIQKRKFDQLEEDDCSSSSLSSGDLSPSPPSSSASPAWTSEE
                     EGLGDQPPQPDQDSSGIQSLMPPSILKRAPRERPGHVAFDGITVYYFPRCQGFTSVPS
                     HGGCTLGMASRHSTCRLFSLAEFKQEQFRARREKLRRRLKEEKLEMLKWKLSVSGVPE
                     AGADVPLTVDAIDDASVEEDLAVAVAGGRLEEANFLQPYPPRQRRALLRASGVRRIDR
                     EEKRELQALRQSREDCGCHCDGVCDPETCSCILAGIKCQMDHTSFPCGCCSEGCENPH
                     GRVEFNQARVQTHFIHTLTRLQMEQGAESLGDPESPMEDVPVEQTVVSPFPPSKPTMS
                     NDLGDSSCGSDMTDSSTTYSSGGSGSRSEAPNHLAHPSLPGSSFRSGIDEDSLEQILN
                     FSDSDLGIEEEEEEGGSVGNLDNLSCFHLADIFGTGDPGSLASWTHSQFGSSLPSGIL
                     DENANLDASCFLSSGLEGLREGSLPSSSGSPEGEAAQSSSLDLSLSSCDSFELLQSLP
                     DYSLGPHYTSRRVSGSLDSLETFHPSPSFSPPRDASFLDSLIGLSEPVTDVLAPLLES
                     QFEDTAVVPLDPVPV"
     misc_feature    399..1073
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     misc_feature    399..1073
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /note="Cysteine/serine-rich nuclear protein N-terminus;
                     Region: CSRNP_N; pfam16019"
                     /db_xref="CDD:464977"
     exon            367..626
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..941
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2933
                     /gene="Csrnp1"
                     /gene_synonym="Axud1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagactcaa gccagcctca cggcaggtag ctgcactcag ccaccatcct tgaaccctct
       61 gagggtcccc aagtcctgga aagactgtta cttgtccaag cactggaggg ttagggaagg
      121 agcctgactg gccgtctgtc ctcagctgct tggaacccct acatcccacc atggctggga
      181 tacagaagag gaagtttgac cagctggaag aggacgactg cagctcctcc tccttgtcct
      241 ctggcgatct ctctccctct cctcccagct cttctgcctc ccctgcctgg acctctgagg
      301 aggagggact gggtgatcag ccaccccagc ctgatcagga ctccagtggc atccagagtt
      361 taatgccccc atccatcctg aagcgggctc ctcgggagcg tccgggtcac gtggccttcg
      421 atggcatcac tgtctactat ttcccgcggt gccagggatt caccagtgtg cccagccatg
      481 gtggctgtac cctgggcatg gcttctcgtc atagcacctg ccgcctcttc tccttagccg
      541 agtttaaaca ggagcagttc cgggctcggc gtgagaagct ccgtcggcgt ttaaaggagg
      601 agaagctaga gatgctgaaa tggaagcttt cagtgtccgg agttccggag gcaggggcag
      661 acgtgccgct cacagtggac gccatcgatg acgcttctgt agaggaggac ttggcagtgg
      721 ccgtggcagg tggccgcctg gaggaagcga atttcctaca gccctatcca cctcggcagc
      781 gacgggccct acttcgcgct tccggtgttc gaaggattga ccgagaggag aagcgcgagc
      841 tgcaggcgct acgccaatcc cgggaggatt gtggttgtca ctgtgatggc gtctgtgacc
      901 ctgagacctg cagttgcatc ctggccggca ttaaatgcca gatggatcac acgtccttcc
      961 cctgtggctg ctgcagcgag ggctgtgaga acccccatgg tcgagtggaa ttcaatcagg
     1021 cgagagttca gacacacttc atccacacgc tcacccgcct gcagatggag cagggtgcgg
     1081 agagtttggg ggacccggag tcccccatgg aggacgttcc tgtcgaacaa accgtggttt
     1141 ccccctttcc tccttccaaa cccactatga gcaatgacct gggggacagc agctgtggca
     1201 gcgacatgac agactcttcc acgacctact cctctggcgg cagtggcagc cgcagcgagg
     1261 ctccgaacca tcttgcccac cccagcctgc caggttccag cttccggtct ggcatagatg
     1321 aagacagcct ggaacagatc ctgaatttca gtgactctga cctcggtatt gaggaagaag
     1381 aggaggaggg agggagtgtg ggcaacttgg ataacctcag ctgttttcat ttggctgaca
     1441 tctttggtac cggtgacccc ggcagcctgg ctagctggac acacagccag tttggctcta
     1501 gccttccatc gggcatccta gatgagaatg ccaacctgga cgccagctgc ttcctaagca
     1561 gcggactcga agggttgaga gaaggtagcc tccccagcag ttctgggtcc cctgaggggg
     1621 aagccgccca gagcagctcc ttggacctca gtttatcctc ctgtgactcc tttgagcttc
     1681 tccaatctct gccagattat agtctggggc ctcactatac ttcccgaagg gtatctggca
     1741 gcctggacag ccttgagacc ttccaccctt cgcccagctt ctctccaccg agggatgcca
     1801 gcttcctgga ttctctcata ggcctgtctg agccggttac agatgtcctg gcgccccttc
     1861 tggagagcca gtttgaggac actgctgtgg tgcctttgga ccctgtgcct gtgtaaggat
     1921 tgagatgact ttttcctgcc ctgagaccct gttgctgctt tttatgtgat cttggtgtcc
     1981 cccaaggtct gtgtatgtaa cggtctcccg tgggctggtt ctgcccccgt gccatgtggg
     2041 caatcctcta tttttacagt aacactctag atttatttat ttttttatgt ttttctgtac
     2101 tgaagggagg gtgggaaggg tatccctctt tcaatgcctg gcctctatgt ccaaacagag
     2161 gtctcccacc tcctactgta tgcctggagg aggaaggggc agggttcaca tcccctcttt
     2221 ctgtactgta aaatgctcct tggtccaaag acagctgaaa agcaggcctt agggtttcct
     2281 gtggaccgtg ggagctaggt cttctggact gtgaagatgt aatttatttc tgtaatttat
     2341 ttggggactg agacagcagt ggttgggcct ctctggcagg tgggcggtgt tgaggcaaag
     2401 tcttcggtgt cccccgccgg tctgggcttc ggtgtggcgt gtaggttcga gctgagcaga
     2461 cggaggctgt gcttgaccat cggtgatcaa aactccctct gccccctgcc cagacgctct
     2521 aacatgccct ctgtccattt ccctctcccc aaggccatgg gttataaagg ccctatgtag
     2581 gatggggagc cagaggccct aagacatgaa gcacacccca gatcactgtc tctagccttt
     2641 ctgggcactg aatccatcct gacccaccac acaccccccg gccagttggc aagaaagagg
     2701 tggctcttgg gggcttttat gcccttcatt agctgatgtt ggattttata tgcattttta
     2761 tattgtctct aagtgtcaga actataattt attcatttct ctgtgtgtgt gtgtgccaag
     2821 aaacgcaggc tctgggcctg cctccttgcc caggaggcct tgccagcctg tgtgcttgtg
     2881 agaacacatt gtacctgagc tgacaggtac caataaagac actctatttt taa
//
LOCUS       NM_001436780            3336 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 6, mRNA.
ACCESSION   NM_001436780 XM_063275195
VERSION     NM_001436780.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3336)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3336)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3336)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275195.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.320967.1,
                                           SRR26360181.1153706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000016.1  19500545-19500690
            147-248             JAXUCZ010000016.1  19508790-19508891
            249-506             JAXUCZ010000016.1  19523772-19524029
            507-639             JAXUCZ010000016.1  19543122-19543254
            640-771             JAXUCZ010000016.1  19543358-19543489
            772-861             JAXUCZ010000016.1  19543675-19543764
            862-1002            JAXUCZ010000016.1  19544907-19545047
            1003-1167           JAXUCZ010000016.1  19545145-19545309
            1168-1447           JAXUCZ010000016.1  19546706-19546985
            1448-1749           JAXUCZ010000016.1  19548553-19548854
            1750-1824           JAXUCZ010000016.1  19549511-19549585
            1825-2017           JAXUCZ010000016.1  19549883-19550075
            2018-3336           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3336
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..146
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            249..506
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2148
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 2 is encoded by transcript variant 6; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 2"
                     /protein_id="NP_001423709.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKL
                     AFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGR
                     HSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRS
                     IPQSATWK"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1504..1605
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1504..1605
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            507..639
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            640..771
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            772..861
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1002
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1167
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1447
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1749
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1824
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2017
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..3336
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgttcctt tagctcccgt aggagcagaa cctagatacg cttcctccag cttggtgggg
       61 tgaccctcct caagcccctg aaaacaccag gaaatattgg ggagagtctt aggtcttcca
      121 actgccctgc ttaggggggg tcacaggttg gccagcacat tgagccagca catccacata
      181 agttgccttt tgacagagct gtggccatga cggcatggta ggaccagcgt cacggaccct
      241 gaggccagaa tgagtgaaga agcatgccga acccgcagtc agaagcgagc ctttgaacct
      301 gacctaacgg aggatgatgt ggagagcaag aaaatgaaaa tggagagagg accatcagaa
      361 ctgccggtgg atggagacag cagggtgatg ccagagccca gtgcaggccc agcccagggg
      421 ttgctgagga caacagaggc catgggcaca ggatctggcg aagggctgtt aggagacggg
      481 cctgtggaca tgcgtacctc acacagtgac atgaagtctg agaagagacc tccctcgcct
      541 gatgtgattg tgctctctga cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc
      601 acagtggcct tgaaagacac cagcactgag gcgctcttga aaagcagccc agaagagcga
      661 gaacggatga tcaagcagct gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg
      721 ttgaagaagc tgcgacagag tcaaatacag aaggaagcca ctgcccagaa gcctacagct
      781 tcctcaggga gcactgtgac cacccctccc ccactcgtgc ggggtcccca gaacattcct
      841 gctggcaagc catcactcca gacctcctcc actcggatac ccggcagcat catcccacca
      901 ccactggtcc gaggtgggca gcaggtgtct gccaaactgg gaccacaggc cagctctcaa
      961 gtagtcatgc caccacttgt caggggagcc caggtgagtc agattcacaa catcagacag
     1021 cattcctcca cggggccacc acccctcctc ctggcccccc gtgcctcagt gcccagcatg
     1081 cagattcagg gacagaggat catccagcag ggactcatcc gggtcgccaa tgtccccaac
     1141 accagtctgc tcgtcaatat ccctcagcct acggcagcct cactgaaggg gacaacagtt
     1201 ggctctgctc aggcaaactc cactcccagc agtgtggctt ctgtggttgc ctctgctgag
     1261 tccccagcta gccggcaggc tgctgccaag ctagcgctgc gcaagcagtt ggagaagaca
     1321 ctgctggaga tccccccacc caagccccct gctccggaga tgaacttctt gcccagtgct
     1381 gccaacaatg aattcatcta tctggtcggc ttggaggaag tggtgcagaa cctgctggag
     1441 acgcaagcgg gcaggatttc tgccacctca gctgctgccg tgttatcccg ggagccttac
     1501 atgtgtgtgc agtgtaagac agacttcaca tgccgctggc gagagaaggg tggagctgtc
     1561 atgtgtgaga actgcatgac atccaaccaa aagaaggcac taaaagtgga gcacaccagt
     1621 cgcctgaagg ccgccttcgt gaaggcgcta caacaagagc aggagatgga gcagcgactg
     1681 ctgcagcagg gcgtaggcac cgccagcatc aaggctgaga ccgcagctcc acatccctcg
     1741 ctgaagcagg tcataaagcc ccgacgtaag ttggcgttcc gctcaggaga ggcccgtgac
     1801 tggaataacg ggtccgtact acagacttcc agccagctgt cccggggttc agccacaaca
     1861 cctcgtggtg ttctgcacac tttcagccag tcacccaaac tgcagaacgc agcctcagct
     1921 acggccctgg taagcaggac tggcagacat tccgagagag tcgtgggcac cagcaagggc
     1981 accgcctcca actggaaaaa gacacctctg agcacaggtg ggacgcttgc cttcgtcagc
     2041 ccaagcttgg cagtgcacaa gagctcctcg gccgtggacc gacagcgaga gtacctcctg
     2101 gacatgattc ctccacgctc catcccccag tcagccacat ggaaatagtg ggagccggcc
     2161 cagccgagga caggccctct gctctcccga ggcccttggt ctaggacacg cagactaccc
     2221 tcctagcaag ttgcctgaga cagctcaggc cttggctctt gccttgctgt ggccaggaga
     2281 gtaccaccat ggtgcccagg atcagaacca gggaccttcc ctatgggcct tctccttcct
     2341 ttttgccttt agtttgcccg acaccagcag aaactcggac cttggggcca gctctgcctg
     2401 gccagcgtgg gtgggagctc accctggaca ctgtgacaca cccgggccag actggcaccg
     2461 ggggctcccg aagttgagcc gggatttcgt tttcttttgg cttttcccat cttagctccc
     2521 cagtctctgc ctcttcatgg ccatctatag gttgaagttt gggttttatt gggttttttg
     2581 tttttgtttt ttttataatc acctcataat gatgatggaa ttaaagtgaa ctgcatagac
     2641 ccagggtcat ggttgtgcac agtgcagtct ggcaggctct accccagagg atgctcagag
     2701 tggcagcagc agagatggca ggtgccaccc tggctctggt cgtgtttgtt gctgctcact
     2761 gcagtccctg gcttccacac ttagcagaat gaaccgcagc ccagatctgt ctgacatcca
     2821 gaggctccag agggatgctg gggtccgcca tgctggagtc agagctgact gctggctggg
     2881 aggctgctgg gttacttttc gtggtttatt ttattaaaaa tttctatcct ttttctcttc
     2941 attttgatgg acacaatctc aagatgccca tgcctgccaa gaggcatcca agtagggccc
     3001 agccagaacc cttaggtctg gagtcagcag ggcttactcc ctcttagcca cagggatgtc
     3061 tgaaagggct gagtctactt ttgttctgtt ttgtttcctt ctccctccac tcttaacaat
     3121 gggttccatg gtgaaaggca gaagcagctc tgtgtccagc acgcacggtg cggccttctg
     3181 ctcatgtgat tggtcgccgt cgtttcccca tccagccctg gtttcccttg acacaataca
     3241 gttagggact ttaatttaaa cccttgttct gcagaccatc gccctctgca gacatgcccc
     3301 tgcctcctcc taataaaggc tcatttaact ccgtga
//
LOCUS       NM_001436779            3386 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 5, mRNA.
ACCESSION   NM_001436779 XM_039094341
VERSION     NM_001436779.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039094341.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50362.1,
                                           SRR26643290.47731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000016.1  19484023-19484218
            197-298             JAXUCZ010000016.1  19508790-19508891
            299-556             JAXUCZ010000016.1  19523772-19524029
            557-689             JAXUCZ010000016.1  19543122-19543254
            690-821             JAXUCZ010000016.1  19543358-19543489
            822-911             JAXUCZ010000016.1  19543675-19543764
            912-1052            JAXUCZ010000016.1  19544907-19545047
            1053-1217           JAXUCZ010000016.1  19545145-19545309
            1218-1497           JAXUCZ010000016.1  19546706-19546985
            1498-1799           JAXUCZ010000016.1  19548553-19548854
            1800-1874           JAXUCZ010000016.1  19549511-19549585
            1875-2067           JAXUCZ010000016.1  19549883-19550075
            2068-3386           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3386
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..196
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            197..298
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    258..260
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            299..556
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2198
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 2 is encoded by transcript variant 5; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 2"
                     /protein_id="NP_001423708.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKL
                     AFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGR
                     HSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRS
                     IPQSATWK"
     misc_feature    696..815
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    696..815
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1554..1655
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1554..1655
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            557..689
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            690..821
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            822..911
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1052
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1217
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1497
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1874
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2067
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..3386
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgccggcg ccgggctcca tgtgtgcggc cgaggggcgc attatctggc cggcggcgcg
       61 ggcgggcgga gcggcggagc gagcgccgcg ggcccgagcg gcccctcagg cgcagcgagc
      121 acgcgcggcc ggcgcccccc gcccccagcc ccgtggacac gcgcgctacc cctgggcccg
      181 gtcggcgcgc ggccgggttg gccagcacat tgagccagca catccacata agttgccttt
      241 tgacagagct gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa
      301 tgagtgaaga agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg
      361 aggatgatgt ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg
      421 atggagacag cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga
      481 caacagaggc catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca
      541 tgcgtacctc acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg
      601 tgctctctga cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct
      661 tgaaagacac cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga
      721 tcaagcagct gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc
      781 tgcgacagag tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga
      841 gcactgtgac cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc
      901 catcactcca gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc
      961 gaggtgggca gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc
     1021 caccacttgt caggggagcc caggtgagtc agattcacaa catcagacag cattcctcca
     1081 cggggccacc acccctcctc ctggcccccc gtgcctcagt gcccagcatg cagattcagg
     1141 gacagaggat catccagcag ggactcatcc gggtcgccaa tgtccccaac accagtctgc
     1201 tcgtcaatat ccctcagcct acggcagcct cactgaaggg gacaacagtt ggctctgctc
     1261 aggcaaactc cactcccagc agtgtggctt ctgtggttgc ctctgctgag tccccagcta
     1321 gccggcaggc tgctgccaag ctagcgctgc gcaagcagtt ggagaagaca ctgctggaga
     1381 tccccccacc caagccccct gctccggaga tgaacttctt gcccagtgct gccaacaatg
     1441 aattcatcta tctggtcggc ttggaggaag tggtgcagaa cctgctggag acgcaagcgg
     1501 gcaggatttc tgccacctca gctgctgccg tgttatcccg ggagccttac atgtgtgtgc
     1561 agtgtaagac agacttcaca tgccgctggc gagagaaggg tggagctgtc atgtgtgaga
     1621 actgcatgac atccaaccaa aagaaggcac taaaagtgga gcacaccagt cgcctgaagg
     1681 ccgccttcgt gaaggcgcta caacaagagc aggagatgga gcagcgactg ctgcagcagg
     1741 gcgtaggcac cgccagcatc aaggctgaga ccgcagctcc acatccctcg ctgaagcagg
     1801 tcataaagcc ccgacgtaag ttggcgttcc gctcaggaga ggcccgtgac tggaataacg
     1861 ggtccgtact acagacttcc agccagctgt cccggggttc agccacaaca cctcgtggtg
     1921 ttctgcacac tttcagccag tcacccaaac tgcagaacgc agcctcagct acggccctgg
     1981 taagcaggac tggcagacat tccgagagag tcgtgggcac cagcaagggc accgcctcca
     2041 actggaaaaa gacacctctg agcacaggtg ggacgcttgc cttcgtcagc ccaagcttgg
     2101 cagtgcacaa gagctcctcg gccgtggacc gacagcgaga gtacctcctg gacatgattc
     2161 ctccacgctc catcccccag tcagccacat ggaaatagtg ggagccggcc cagccgagga
     2221 caggccctct gctctcccga ggcccttggt ctaggacacg cagactaccc tcctagcaag
     2281 ttgcctgaga cagctcaggc cttggctctt gccttgctgt ggccaggaga gtaccaccat
     2341 ggtgcccagg atcagaacca gggaccttcc ctatgggcct tctccttcct ttttgccttt
     2401 agtttgcccg acaccagcag aaactcggac cttggggcca gctctgcctg gccagcgtgg
     2461 gtgggagctc accctggaca ctgtgacaca cccgggccag actggcaccg ggggctcccg
     2521 aagttgagcc gggatttcgt tttcttttgg cttttcccat cttagctccc cagtctctgc
     2581 ctcttcatgg ccatctatag gttgaagttt gggttttatt gggttttttg tttttgtttt
     2641 ttttataatc acctcataat gatgatggaa ttaaagtgaa ctgcatagac ccagggtcat
     2701 ggttgtgcac agtgcagtct ggcaggctct accccagagg atgctcagag tggcagcagc
     2761 agagatggca ggtgccaccc tggctctggt cgtgtttgtt gctgctcact gcagtccctg
     2821 gcttccacac ttagcagaat gaaccgcagc ccagatctgt ctgacatcca gaggctccag
     2881 agggatgctg gggtccgcca tgctggagtc agagctgact gctggctggg aggctgctgg
     2941 gttacttttc gtggtttatt ttattaaaaa tttctatcct ttttctcttc attttgatgg
     3001 acacaatctc aagatgccca tgcctgccaa gaggcatcca agtagggccc agccagaacc
     3061 cttaggtctg gagtcagcag ggcttactcc ctcttagcca cagggatgtc tgaaagggct
     3121 gagtctactt ttgttctgtt ttgtttcctt ctccctccac tcttaacaat gggttccatg
     3181 gtgaaaggca gaagcagctc tgtgtccagc acgcacggtg cggccttctg ctcatgtgat
     3241 tggtcgccgt cgtttcccca tccagccctg gtttcccttg acacaataca gttagggact
     3301 ttaatttaaa cccttgttct gcagaccatc gccctctgca gacatgcccc tgcctcctcc
     3361 taataaaggc tcatttaact ccgtga
//
LOCUS       NM_001436788            3319 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 15, mRNA.
ACCESSION   NM_001436788 XM_063275204
VERSION     NM_001436788.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3319)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275204.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-564             JAXUCZ010000016.1  19523772-19524029
            565-697             JAXUCZ010000016.1  19543122-19543254
            698-829             JAXUCZ010000016.1  19543358-19543489
            830-919             JAXUCZ010000016.1  19543675-19543764
            920-1060            JAXUCZ010000016.1  19544907-19545047
            1061-1225           JAXUCZ010000016.1  19545145-19545309
            1226-1505           JAXUCZ010000016.1  19546706-19546985
            1506-1807           JAXUCZ010000016.1  19548553-19548854
            1808-2000           JAXUCZ010000016.1  19549883-19550075
            2001-3319           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3319
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            307..564
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2131
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 5 is encoded by transcript variant 15; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 5"
                     /protein_id="NP_001423717.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQTSSQLSRG
                     SATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSERVVGTSKGTASNWKKTPLSTGG
                     TLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1562..1663
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1562..1663
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            565..697
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            698..829
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1060
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1225
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1505
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1807
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2000
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..3319
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcgaatg agtgaagaag catgccgaac ccgcagtcag aagcgagcct ttgaacctga
      361 cctaacggag gatgatgtgg agagcaagaa aatgaaaatg gagagaggac catcagaact
      421 gccggtggat ggagacagca gggtgatgcc agagcccagt gcaggcccag cccaggggtt
      481 gctgaggaca acagaggcca tgggcacagg atctggcgaa gggctgttag gagacgggcc
      541 tgtggacatg cgtacctcac acagtgacat gaagtctgag aagagacctc cctcgcctga
      601 tgtgattgtg ctctctgaca gcgagcagcc atcaagcccg agggtgaatg gcctgaccac
      661 agtggccttg aaagacacca gcactgaggc gctcttgaaa agcagcccag aagagcgaga
      721 acggatgatc aagcagctga aggaggaatt gaggctagag gaagcaaagc tggtcttgtt
      781 gaagaagctg cgacagagtc aaatacagaa ggaagccact gcccagaagc ctacagcttc
      841 ctcagggagc actgtgacca cccctccccc actcgtgcgg ggtccccaga acattcctgc
      901 tggcaagcca tcactccaga cctcctccac tcggataccc ggcagcatca tcccaccacc
      961 actggtccga ggtgggcagc aggtgtctgc caaactggga ccacaggcca gctctcaagt
     1021 agtcatgcca ccacttgtca ggggagccca ggtgagtcag attcacaaca tcagacagca
     1081 ttcctccacg gggccaccac ccctcctcct ggccccccgt gcctcagtgc ccagcatgca
     1141 gattcaggga cagaggatca tccagcaggg actcatccgg gtcgccaatg tccccaacac
     1201 cagtctgctc gtcaatatcc ctcagcctac ggcagcctca ctgaagggga caacagttgg
     1261 ctctgctcag gcaaactcca ctcccagcag tgtggcttct gtggttgcct ctgctgagtc
     1321 cccagctagc cggcaggctg ctgccaagct agcgctgcgc aagcagttgg agaagacact
     1381 gctggagatc cccccaccca agccccctgc tccggagatg aacttcttgc ccagtgctgc
     1441 caacaatgaa ttcatctatc tggtcggctt ggaggaagtg gtgcagaacc tgctggagac
     1501 gcaagcgggc aggatttctg ccacctcagc tgctgccgtg ttatcccggg agccttacat
     1561 gtgtgtgcag tgtaagacag acttcacatg ccgctggcga gagaagggtg gagctgtcat
     1621 gtgtgagaac tgcatgacat ccaaccaaaa gaaggcacta aaagtggagc acaccagtcg
     1681 cctgaaggcc gccttcgtga aggcgctaca acaagagcag gagatggagc agcgactgct
     1741 gcagcagggc gtaggcaccg ccagcatcaa ggctgagacc gcagctccac atccctcgct
     1801 gaagcagact tccagccagc tgtcccgggg ttcagccaca acacctcgtg gtgttctgca
     1861 cactttcagc cagtcaccca aactgcagaa cgcagcctca gctacggccc tggtaagcag
     1921 gactggcaga cattccgaga gagtcgtggg caccagcaag ggcaccgcct ccaactggaa
     1981 aaagacacct ctgagcacag gtgggacgct tgccttcgtc agcccaagct tggcagtgca
     2041 caagagctcc tcggccgtgg accgacagcg agagtacctc ctggacatga ttcctccacg
     2101 ctccatcccc cagtcagcca catggaaata gtgggagccg gcccagccga ggacaggccc
     2161 tctgctctcc cgaggccctt ggtctaggac acgcagacta ccctcctagc aagttgcctg
     2221 agacagctca ggccttggct cttgccttgc tgtggccagg agagtaccac catggtgccc
     2281 aggatcagaa ccagggacct tccctatggg ccttctcctt cctttttgcc tttagtttgc
     2341 ccgacaccag cagaaactcg gaccttgggg ccagctctgc ctggccagcg tgggtgggag
     2401 ctcaccctgg acactgtgac acacccgggc cagactggca ccgggggctc ccgaagttga
     2461 gccgggattt cgttttcttt tggcttttcc catcttagct ccccagtctc tgcctcttca
     2521 tggccatcta taggttgaag tttgggtttt attgggtttt ttgtttttgt tttttttata
     2581 atcacctcat aatgatgatg gaattaaagt gaactgcata gacccagggt catggttgtg
     2641 cacagtgcag tctggcaggc tctaccccag aggatgctca gagtggcagc agcagagatg
     2701 gcaggtgcca ccctggctct ggtcgtgttt gttgctgctc actgcagtcc ctggcttcca
     2761 cacttagcag aatgaaccgc agcccagatc tgtctgacat ccagaggctc cagagggatg
     2821 ctggggtccg ccatgctgga gtcagagctg actgctggct gggaggctgc tgggttactt
     2881 ttcgtggttt attttattaa aaatttctat cctttttctc ttcattttga tggacacaat
     2941 ctcaagatgc ccatgcctgc caagaggcat ccaagtaggg cccagccaga acccttaggt
     3001 ctggagtcag cagggcttac tccctcttag ccacagggat gtctgaaagg gctgagtcta
     3061 cttttgttct gttttgtttc cttctccctc cactcttaac aatgggttcc atggtgaaag
     3121 gcagaagcag ctctgtgtcc agcacgcacg gtgcggcctt ctgctcatgt gattggtcgc
     3181 cgtcgtttcc ccatccagcc ctggtttccc ttgacacaat acagttaggg actttaattt
     3241 aaacccttgt tctgcagacc atcgccctct gcagacatgc ccctgcctcc tcctaataaa
     3301 ggctcattta actccgtga
//
LOCUS       NM_001436771            1860 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 4, mRNA.
ACCESSION   NM_001436771 XM_039109887
VERSION     NM_001436771.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 1860)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 1860)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 1860)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039109887.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.254249.1,
                                           SRR22399489.587421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1256           JAXUCZ010000005.1  102900532-102900653 c
            1257-1860           JAXUCZ010000005.1  102898944-102899547 c
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1860
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1281
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 4 is encoded by transcript variant 4; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 4"
                     /protein_id="NP_001423700.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKQKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEHQTTCNLQ"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    <607..>1254
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <607..>1254
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1256
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1860
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagcagaag
     1141 agaaagggtg gaagaaactt ccaggctgct cacaggagga acatgctaaa aggccaacat
     1201 gagaaagaag ctgcagatcg gaaacgcaag caggaggaac aaatggagac tgagcaccaa
     1261 acaacatgta atctacagta ataaaaatat atctcatttt gggctcaaag cattaatcca
     1321 gtaactgaaa agagaatacg agtggagcat acaagcgatg aagatcttga gacagactca
     1381 ttggactgaa ttttcccctc cccccttgat ggaagaaatg ttccagattc taaattgagg
     1441 acttcactat taatggcatt attaactgtg ttatgattgt taacaaaata tcctgtaagg
     1501 tacacactac atattaaggt tggccatcat tcctgttttt ttttttagcc aagcttaaaa
     1561 tgaagctttg tgtttgaagt tataacaaac atagatgaag tcggtggttg tacattattt
     1621 catttagaaa atatgaaaac tcattttgtt ttgaagatag gtattaaact gaaatagcta
     1681 ttacgttctt gaaaaatggg gcaggtgtgc ccttcccttg acattctttt gttgttaagt
     1741 tctttagagt cttgtttttt tttttctttt taatcctgag agattaaaca gtagacttgt
     1801 taagtaaaaa tatgaaactg taaccaaaat tttaaaataa agtttttttt aaaaaaaaaa
//
LOCUS       NM_001436813            5206 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 8, mRNA.
ACCESSION   NM_001436813
VERSION     NM_001436813.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5206)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 5206)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2870990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000016.1  52867643-52867789   c
            148-256             JAXUCZ010000016.1  52866109-52866217   c
            257-709             JAXUCZ010000016.1  52856986-52857438   c
            710-1806            JAXUCZ010000016.1  52848306-52849402   c
            1807-2075           JAXUCZ010000016.1  52836572-52836840   c
            2076-2226           JAXUCZ010000016.1  52822585-52822735   c
            2227-5206           JAXUCZ010000016.1  52818692-52821671   c
FEATURES             Location/Qualifiers
     source          1..5206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..5206
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..147
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            148..256
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2354
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 5 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 5"
                     /protein_id="NP_001423742.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MWTRLVWTPSEICLPLLSEYWNQRITRLQHLCRKPSQMSKPTAA
                     SWLYEQVMPWTAGRPWRSPFHEPPSLLEALPRSCRPYSAGLITVTGSLGTMDDRSAAR
                     TIFGRDSVPRSPRLSPSAESLPRSFRPRSRVRESPLASNAWEGEMWCGCACAERTRTR
                     TLGAARESVAATVPRYTFGIMDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQND
                     DDFKEGINKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKP
                     KFPSKEQHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYY
                     TDGEESSDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIG
                     SDMQNKPDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPAS
                     TPDSSPAQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQN
                     FAPKSSVLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNY
                     SFTREEVRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQR
                     IERENMALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRG
                     ASRTSSATSGLSCKTDRSVLDTSSGFLLRPKPPNVRTAWL"
     misc_feature    1788..2096
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1788..2096
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            257..709
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1806
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2075
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2226
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..5206
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccggta ctcacccgca gcggacagcg gacggccgcc gccagccggc tccaggaaga
       61 ggcgaagtcc ggcggctggg cgcgcgggct ccagcagacg agcgcgacca gtgtccccag
      121 cagcaaggcg gccgcggcgc agctcagggt ctctctgtgt aaacctggct atcctgaaac
      181 tcactatgtg gaccaggcta gtctggactc cctcagagat ctgcttgcct ctgctttcag
      241 agtactggaa tcaaagaatt acaagattac agcatctttg taggaaacca tcccagatgt
      301 ctaaacctac cgcagcgtcg tggctgtacg agcaggtgat gccctggaca gcagggaggc
      361 cctggcggtc tcctttccac gagcccccaa gtcttctcga ggccctgccg agaagctgtc
      421 gcccctacag tgcaggcctc atcactgtga cggggtctct tggaactatg gacgacagga
      481 gcgctgccag gaccatcttc ggcagagact ccgttccgcg atcgccccgc ctttcccctt
      541 ccgctgagtc tctccccagg agcttccgcc cgcgctcacg tgtgcgcgag tctccgctag
      601 cttccaacgc gtgggaggga gaaatgtggt gtggctgcgc gtgcgcagag cgaacgagaa
      661 cccgaacgct cggcgcggcg cgagagtcgg tagcggccac agttcccaga tatacttttg
      721 gcatcatgga tcggtttggc gatatctcag aaggtgaagt ggaccattct ttctttgaca
      781 gtgattttga agacacaaag aaatgtgaaa gtaattccat ttttgacaag caaaatgatg
      841 atgactttaa ggaaggaata aataaggaca tcaaaaattt aaacttgaaa tttggagtac
      901 aaaatgataa ccttaaagag aaaatagata atgacacaga aaatgtgaac gtgaaacttg
      961 ggatacaaac aaaggaaaat taccttactc agaagggaaa tgaaaggaaa ccaaaatttc
     1021 cctcaaagga acaacatgta gaaaatgacc ctatacaaac aagaagtccc tcattgttga
     1081 cttcttcaag gtcaaaaaaa ctgtgtgata ccacaaaagg aaataaacta catttgcctg
     1141 ttccaaatag aattcctaaa attgtgaaag gtgaggatga ctactacaca gatggagagg
     1201 aaagcagtga cgatgggaag aagtaccacg tgaggtctaa gtcagcgaag ccctctagta
     1261 acttaaaaaa gaacaacaca agtaagaagt attccaaagc cagttcctcc tctctgtctt
     1321 cctcatcttc acgatcaagc tcagactgct cagatatagg atctgacatg caaaataaac
     1381 ctgattcagg ttcatcaggg aaacgagttt ctagtgtaac cccctcatca ccaaagcaga
     1441 agtgtaagtc aggaagaaaa tcaagtgcta aacagaaggc aggtgactat aatgcagagt
     1501 cagaagacaa cgtaacagac gtaactcccg cgtcaactcc agacagcagc cctgcccagc
     1561 catttgagtt gagccaatca cagaatcaaa aagtaaaagt taaaagacaa gaaaatgtga
     1621 gccgggatgt gtatgaggat gtggaggctt taaagaatga ttcaagatgt ctgaaatcag
     1681 ccaaaaggaa agaaaagcat ggacagaatt ttgctccaaa atcatcagtg ttagatgcaa
     1741 atctagaccg tagatccaag caaaaagtct tacatgacac aatggacctt aatcatctgt
     1801 tgaaagcttt cctgcagtta gataaaaagg gaccacagaa acatcacttt gagcagcctt
     1861 caataatacc taggaaaaac tactctttca caagagaaga ggtgagacag attgatcggg
     1921 agaatcagag gcttttgaaa gaactgtcaa gacaggctga aaaaccagga aacaaaagta
     1981 caattcctgg aagatcgctc ggccatccac ctaagttgta tcacagtgct ctcaacagac
     2041 agagggaaca gcaaaggatt gaaagagaaa atatggcttt attgaaacgg cttgaagctg
     2101 tgaagccaac agttggcatg aaacgctctg aacagctgat ggactaccat cggaatatca
     2161 gttacctcaa cccttcaccg tccgtcagac gagtgagatc tactcttggc cattacagcc
     2221 cactgagagg agcttccagg acatccagtg caaccagtgg tctcagttgt aagactgatc
     2281 gatcagtgtt ggacacatcc agtggctttt tgctaagacc gaaacccccg aatgttcgta
     2341 ctgcttggtt gtaaaacctt tttttatgat atacattgtt catctgttgg tcctgtttta
     2401 acgatgtatt tttctgtact actataacta tttgcaaaca tctgtcatac ttttccaaca
     2461 atttatacag caatgagtat aatttattgt tattcagtgc aaattgttat caaaagacac
     2521 tttgatgtaa aatcagtgtt tcatgcagtg gcatatttat aggagccata tgtctatttc
     2581 atagagaaag gtgtatgcat gaatgtttct tcgatatagg aattcagctg ttgtgctgac
     2641 aaagcagcag tggtggtaat ccatgttgaa accaagacgc tcactatata gttcttaatc
     2701 tatatgagtt tcagttattg taagcgttaa ggtgctttac cttgtaaact taagcgcctc
     2761 atgcttctgt ctgctttaga ctgtctgtaa cacgagtcag cacttgctta tgtgagtgtt
     2821 ccactccaaa tgaaaaaaac ttgaaatttg ttttcatgga gaagctggtg tagtcttgat
     2881 gaggagcatg agcagcttgt atcagtgcag ctcttgcttg actaacgacg cttctcccta
     2941 agtctgatta tctattccaa accgtttcac cccatgaatg aggggttcac tttagaagcg
     3001 tctgtttcat gtttatatgc agtctggtaa aataccctta aggattctga ggcaagagag
     3061 aggctttaac agcttcgagt cttgtgactt gtgactggtt tggatccaga tcatttgcat
     3121 cattaacaaa agcatgtgtt tatggatcag ggagcaacat tcccagcttg aagaccaggg
     3181 tgtgttagag cagtgtttga aatgatactg ttagtgtgtg tgctgtcgtt gtgtatttat
     3241 tgtattaata gaatgcttag agtaaggaag aaatgattag agaaaccaaa tacaaacaag
     3301 aaagaaacta atcacacatt ggtcacagct actgccttaa tgttagtgaa tgtccttggc
     3361 ttgctttagc tgagtcctgg aagcaccagt cttcagtctc atgtttgaag gtctgttaat
     3421 cctcatggac ttgctagtga cccacagatg tgaaatagtt gactatgaaa aactagaata
     3481 ttttcctgtc aacctagagg ctgttctttt gtagaacaaa gtgtgtgata tttcatagtc
     3541 atagcctttc attgctggtc ttgtcagtat gcctttagta aatacctttt atattcaatg
     3601 acacgctttt cttaaaatat gaattttccc tgaccacaga gagatctgtc tggttcagtg
     3661 ctcagcactg gagcatgtgg gccacacctg cttcgccttc cgtagcaggg aggccgactg
     3721 cccttaccaa gcaccaggtc acacattgtt agtctcactt taatggatgg tgttccagat
     3781 agagcagtga tggtaggaaa tggtgagacc acaacaatgc tgatatacat agcatacaca
     3841 cacatacact ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     3901 ctcacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacgactaag
     3961 ggtttttctg ctgcttttgg aggactgtaa cattctataa caatttattt ctttgtttta
     4021 gtgaacaaga ttttgtacct gctctatata ccccttttaa tgtttttgta acaacttaaa
     4081 tttaaaatgc aacattttgg catttgctca gtagtgaatc actttaaagc agatttttgt
     4141 gggaaaaaaa cttgtatatg taaaaccttc tatgttcaca gtggcattag cctaggcaca
     4201 tttttgttgg tctctccaag ttccatagat aaactagaat ttgattttaa atgctaattt
     4261 atgtcttagt ttttactgtt tggaagaagt ttaactaagt gttactgatg acaaggattc
     4321 aacctcaagt aaagggcaac catcttttaa aagcaattta gcttgttata ttgtaggtgc
     4381 atagatctgg tgactgtaga gatgggtagg agttatactc agaactcact gatggacgtc
     4441 aaggtactgt taggtaggat taggaagcct ttgcaatgga ggagtcatga gtacattaat
     4501 ctcttcagcc tcaccaacac aaacatgtac tcttagcact gttgcatggt tggctggctg
     4561 gtccttacca agcatacttg gaaggcccac atctgtagct agaaagcgtg ctggtctgct
     4621 gcctagagac agatctgaga actgttttca tctctgtcaa atgttatctc cttttctagt
     4681 aagtttttgt gagatttcaa attattaaaa ttacttctta aggagtagct actacctcat
     4741 cctccccaac tgactctttc agtccccatc aaaacctgct ctaactgcta ttccagttaa
     4801 cactctatgg cttgcttgtt taataacatc atgcacttgt gctcaaccca agtatcagaa
     4861 acgcgactcg cggctttgag aggtgattgt gataggtctg cttctcatct gcagatacaa
     4921 tgcagcaact ccaaagtatt aagatcacac taagctgaag atgcaccttt gccctggtta
     4981 gcaacgcaaa accgtatcgt catacatgcc aaggccttag cgtgtagatg tctgtacacc
     5041 ggcacagcga atgagctcac tgctaatggc tgagttgctt attttcatga acaaagatta
     5101 gcaagaaact gttaaaccat ctttttaaaa actgttctag tttgtcatat tttaggcatg
     5161 aagaactagc ttggcttact gaagaaataa aagatttaaa gagaac
//
LOCUS       NM_001436840            3754 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 10, mRNA.
ACCESSION   NM_001436840
VERSION     NM_001436840.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20636.1,
                                           SRR26360186.1521925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-389             JAXUCZ010000005.1  152869903-152870032 c
            390-560             JAXUCZ010000005.1  152868094-152868264 c
            561-676             JAXUCZ010000005.1  152867543-152867658 c
            677-880             JAXUCZ010000005.1  152866067-152866270 c
            881-1069            JAXUCZ010000005.1  152864590-152864778 c
            1070-1189           JAXUCZ010000005.1  152864177-152864296 c
            1190-1464           JAXUCZ010000005.1  152861132-152861406 c
            1465-1545           JAXUCZ010000005.1  152855768-152855848 c
            1546-1632           JAXUCZ010000005.1  152855321-152855407 c
            1633-1777           JAXUCZ010000005.1  152852539-152852683 c
            1778-1906           JAXUCZ010000005.1  152850411-152850539 c
            1907-2368           JAXUCZ010000005.1  152847583-152848044 c
            2369-2564           JAXUCZ010000005.1  152846792-152846987 c
            2565-2774           JAXUCZ010000005.1  152844978-152845187 c
            2775-3754           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3754
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..389
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Srrm1"
                     /note="upstream in-frame stop codon"
     exon            390..560
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2882
                     /gene="Srrm1"
                     /note="isoform 10 is encoded by transcript variant 10;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 10"
                     /protein_id="NP_001423769.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELK
                     KEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRR
                     SSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKSPELPEPSVRMKDSSVQEATSTSD
                     ILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHR
                     SRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSS
                     SSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSSPATPPPKTRHSPTPQQ
                     SNRARKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAAD
                     SVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRK
                     RQKETSPRSRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRRSPTPPPRRRTPSPPPR
                     RRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRS
                     PPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPRPRAPQTSSPPPVRRGA
                     SASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPTAK
                     KPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHK
                     KDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPRKETESEAED
                     DNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    <405..500
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <405..500
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    1347..>2384
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1347..>2384
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    <1983..2570
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1983..2570
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            561..676
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..880
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1069
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1189
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1464
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1545
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1632
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1777
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1906
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2368
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2564
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2774
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..3754
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaagg cctgaaccaa aatggaagtt attccttgcg tctgaagtat
      301 agcaccatca ccttattagg tcacagcaga gtgagtgtcc caatgtcgct ctgacccaac
      361 tcccttgatg acgcagtgtg tgtttggaga acccagattc caaaatgatg caaatcaacc
      421 tgactggatt tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc
      481 tgttaagtgc acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg
      541 aagagataaa gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg
      601 aagataaaga taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt
      661 ctcgcagccc aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg
      721 tcaggagaga gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga
      781 gcccttcccc tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga
      841 gaatgaaaga ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca
      901 agcctgagcc tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa
      961 aggaaaagac tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc
     1021 ggtcaccttc tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc
     1081 ctagaaggcg accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac
     1141 ggatgcctcc tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt
     1201 cttccgcatc gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc
     1261 caaagaagcc tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt
     1321 cggcaagtcc tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa
     1381 ctcgccattc cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt
     1441 ctccaggaag aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac
     1501 cttctccagc acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca
     1561 gcaaaatggc tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc
     1621 agtcttcatc tgactctggc tcctcttcca cctcagaaga tgagcggccc aagagatccc
     1681 atgtgaagaa tggtgaggta ggcaggcggc ggagacattc tccttctcgg agtgcctctc
     1741 catcacctcg aaagcgccaa aaagagactt cccctcgtag tagaaggagg agaagtcctt
     1801 ccccacctcc tgccagaaga cgacgatctc cttctccagc ccctcctccc cctcctcccc
     1861 cacctcctcg gcggcgcaga tctcccaccc caccaccacg acgaaggacc ccttctcctc
     1921 ccccacgccg ccgctcaccg tctccaagaa gatactctcc tcccatccag aggagatact
     1981 ctccttcccc acctccaaag aggagaactg cctcgccccc acccccaccc aagcgaaggg
     2041 catcgccatc tcctccacca aagcgccggg tttcccactc tccacctcct aaacaaagaa
     2101 gccccccagt caccaagaga cgctcaccct ccttatcttc aaagcatagg aaagggtctt
     2161 ccccaggccg ctccactcgg gaggcccggt caccacaacc aaacaaaagg cactcgccct
     2221 caccacgacc tcgggcgcct cagacctcaa gccctccccc tgttcgaaga ggagcttcag
     2281 cgtctcccca aggaaggcag tccccgtctc cgagtactag gcctattagg agagtctcca
     2341 ggactccgga acccaaaaag ataaaaaagg ctgcctcacc aagccctcag tccgtaagaa
     2401 gggtttcatc ttcccgctct gtctctggat ctcctgagcc aacagctaaa aagcctccag
     2461 cacccccctc tcctgtgcag tctcagtcac cctccacaaa ctggtcacct gcagcaccag
     2521 ccaagaaggc taaaagccca acaccaagcc cgtcccctgc caggaattct gatcaagaag
     2581 gaggtggaaa gaagaagaag aagaagaagg acaagaaaca taagaaggat aagaaacaca
     2641 agaagcacaa aaaacacaag aaggagaagg ctgtggccgt agccacccca gctcctgctg
     2701 cccctgcagc tgtctctgct gccgccactc catcagccca ggaagagcct gcggcagcac
     2761 cagagcccag gaaggagact gagagtgaag ctgaagatga caaccttgat gacttagaga
     2821 ggcaccttcg ggagaaggcc cttcgatcca tgcggaaggc ccaagtgtcc ccacagtcct
     2881 aggcggacat gtttgttacg ttgtaaattt tatttggttt gtactcaatt caatttcaaa
     2941 attgctaaaa tgtgtttgag ctttagacta taacatttgt tgtaataatt gctaggttga
     3001 agttcaccat gttaaaaaag gggggcatgg atttacatta caaaggtgtc cacggtgtat
     3061 tagtgacaat tcttccattg acatttagag tgaaatattt taagccaaaa aaaaatctct
     3121 tttttaaaaa agggggtttg aatattgttg gcatttttgt ggttccttta aatgccctcg
     3181 cctctcccaa aaggttgggg tcttttcttt ttctccctat tctcttgaat cttagcaccc
     3241 atgtaaatta tgcttccaac cttgtatagg tttgtaagct tgcccagaag tgagagcact
     3301 gttgaagtac cacagaggtt tgggcgagtg agtgttgact ctgttgccca tggagtctgc
     3361 tgtcctggca gcatcccagc tctagagcgc cgcactcctg agctacaggg ctgccccatg
     3421 gaacagttcc taaactgact aggaactctg ggttttctcc ttccggttgt gttgttttgt
     3481 ttccttctcc ccttttcttc ctcttttgta aaggcgattc actagaccca ggaaggaccc
     3541 ttcagttaca taaatttgtt ttatgaaaca tggtggctcc cattcatggt ttcccttact
     3601 cttccaattg gtacacacaa ctgaggagct cctgtatttg gccggctgga agggcctgga
     3661 cagtgtcttg atttcacttg ttttatttta ttttattttt taactaaagc tatataaagc
     3721 ttgtggatta aacagaataa atttctaaat ttaa
//
LOCUS       NM_001436765            4272 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 2
            (Lingo2), transcript variant 3, mRNA.
ACCESSION   NM_001436765 XM_063287599
VERSION     NM_001436765.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287599.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.298814.1,
                                           SRR26360172.766690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000005.1  55310716-55310907   c
            193-4272            JAXUCZ010000005.1  55166250-55170329   c
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21-q22"
     gene            1..4272
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine rich repeat and Ig domain containing 2"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
     exon            1..192
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            193..4272
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="upstream in-frame stop codon"
     CDS             228..2048
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2
                     precursor"
                     /protein_id="NP_001423694.1"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
                     /translation="MLHTAIPCWQPFLGLAMVLLFMGSTIGCPARCECSAQNKSVSCH
                     RRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFN
                     NLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV
                     GDNDLVYISHRAFSGLFSLEQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNINNMPV
                     YAFKRLFHLKQLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLT
                     HLNLSYNPISTIEAGMFSDLIRLQELHVVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE
                     TLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQATLQFGGQQPMCAGPDTIRERS
                     FKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRR
                     FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRF
                     LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVW
                     SRGKGKHKNSIDLEYVPRKNNGAVAEGEVAGPRRFNMKMI"
     sig_peptide     228..308
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    306..407
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    306..407
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    342..398
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    342..398
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    369..>1247
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    369..>1247
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    402..473
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    402..473
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    474..545
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    474..545
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    546..617
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    546..617
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    618..689
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    618..689
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    690..761
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    690..761
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    762..833
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    762..833
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    834..977
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    834..977
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    978..1049
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    978..1049
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1050..1121
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1050..1121
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1122..1193
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1122..1193
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1194..1256
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1194..1256
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1206..>1400
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1206..>1400
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1458..1727
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1458..1727
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1509..1523
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1509..1523
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1548..1562
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1548..1562
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1623..1637
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1623..1637
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1665..1682
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1665..1682
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1704..1715
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1704..1715
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
ORIGIN      
        1 agggcactct agaaacccag cctgcatgta gacagccctg cctactgcag aagatgattc
       61 ctgccccggg ttaaacgtgt acaactcgtg gaaatgccag taccttccac ctgaaggcac
      121 ttagtggcta gaaaaccagc aatctacccc gaaacacact gtactaaaca cagcaagaga
      181 ccacaatgat tggcccataa ccaaggtgta gaataaacag tggagtcatg cttcacacgg
      241 ctataccatg ctggcagcca ttcctgggtc tggctatggt gttactcttc atgggatcca
      301 ccattggctg tcctgctcgc tgtgagtgct ctgcccagaa caaatctgtt agctgccaca
      361 gaagacgctt gatcgcgatc cccgaaggca ttcccattga gaccaaaatc ttggacctga
      421 gcaaaaatcg actaaagagc ataaaccccg aagaattcat ctcatatcct ctgttggagg
      481 agatagactt gagcgacaac atcatcgcca atgtagaacc tggggcattt aacaatctct
      541 ttaacctgcg ttccctccgc ctaaaaggca atcgccttaa gttggtccct ttgggagtat
      601 tcacgggact gtccaacctc accaagcttg acattagtga gaataagatt gtcattttgc
      661 tggactacat gttccaggat ctgcataacc tgaagtctct agaagtgggg gacaatgatt
      721 tggtttatat atcacacagg gccttcagtg gactatttag cttggagcag ctcaccctgg
      781 agaagtgcaa cttgacagcg gtaccaacag aagccctttc ccatctccgc agcctcatca
      841 ccctgcatct gaagcatctc aatatcaaca atatgcctgt gtatgccttt aaaagattat
      901 tccacctgaa acaactagag atcgactatt ggccattgct ggatatgatg ccagccaata
      961 gcctctatgg tctcaacctc acatccctct cgatcactaa caccaacctg tccactgtcc
     1021 ctttcctcgc ctttaaacac cttgtatacc tgacccacct taacctctcc tacaatccca
     1081 tcagcactat tgaagcaggc atgttctctg acctgatccg cctacaggag cttcatgtag
     1141 tcggggccca gctccgcacc attgaacctc actccttcca agggctccgc ttcctccgcg
     1201 tgctcaatgt atctcagaac ctgctggaaa cattggaaga gaatgtcttc tcttccccta
     1261 gggctttgga ggtcctgagc attaacaata acccactagc gtgcgactgc cgacttctct
     1321 ggctcctgca gcgacaggcc accctgcagt ttggaggcca gcagcccatg tgtgccgggc
     1381 cagacaccat acgtgagagg tcatttaagg atttccatag cactgctctt tctttttatt
     1441 ttacctgcaa aaaacccaaa atccgtgaaa agaagttaca gcacctccta gtggacgaag
     1501 gacagacggt ccagctggag tgcaacgcgg atggagaccc ccagcccgtg atttcctggg
     1561 tgacacctcg aaggcgtttt atcaccacca agtccaacgg aagggccact gtgttgggtg
     1621 atggcacctt agaaatccgt ttcgcccagg atcaagacag tgggatgtat gtttgcatag
     1681 ctagcaatgc tgctgggaat gacaccttca cggcatctct cactgtgaag ggattcactt
     1741 cagaccgctt cctttacgca aacaggaccc ctatgtacat gactgactcc aatgacaccg
     1801 tttccaacgg cactaatgcc aatacttttt ccctggacct taaaacaata ctggtatcta
     1861 cagccatggg ctgtttcaca ttcctgggag tggttttatt ttgttttctc cttctttttg
     1921 tgtggagccg aggaaagggc aaacacaaaa acagcattga ccttgagtat gtgccccgaa
     1981 aaaacaatgg tgctgttgca gaaggggagg tggctggacc caggaggttc aacatgaaaa
     2041 tgatataagg gcccaccaca cacacactac tactgtctct gtgttactgt tggtaatgag
     2101 taagacgtct gatatagcga gtccatcaca aggtgatcag gcagcttcac acagctgccc
     2161 ctgtgtcaaa gcagggtcca tggaagctgg aagacttctc atggacactg gctgattaga
     2221 ggcaggcagg catgtgtcag agcccttcac acagtgggat actaattgtt tgcattgcaa
     2281 atattggcat tctggggatc tcagtaatga ccctgaacct ttggctcatg ctgacggaca
     2341 aaaattcaac attttctacc actgcaaaac taaaagaaaa aaaatttaaa aggaacaacc
     2401 tacagtgtag gatttacata ttaaaaaaag acacatttgt ctaaaacata ctctacggta
     2461 aaatttgtat ttattatcat ttgttaaaac cttgcatcat acaatactgt tggttcagca
     2521 ccaaaaaaaa aaaaaaaaaa aaaaagagag atcaatatat tcttttttga aacatatatg
     2581 ctgtatatgt tttaaagcaa tatgaatgag aggttgtgct tttagttact caccagtata
     2641 gatccaagtg tggtctcact ttccttttat ccgcagagaa acctgagaat agatccctgg
     2701 aataataggc tgagatgtgt tgagatgtgt atgtctgatg taggatgcca agatacaaga
     2761 gcccagtcaa aactgctcaa ctctgttaac ttctgttact ataaataaag gcatgtgcct
     2821 agttttgata cagaatggaa tattttttat atgtacacta ccaacctgga ccagtttact
     2881 gtaacagaag cccttggttt ctccagaagg tggtacgtct ctagatgtgc ctgtagaatg
     2941 caaggtaggt gccactcata aaagtgatcc atttagctac tgcttagttt tacttttgcc
     3001 agtcactgct aaggggttaa tgaccaatgg aaaagagaat attgatcata tagatttggc
     3061 aatagtcgcc aatgtctaat gtcaataatt ctgttaccca aaagctctct ggataaagag
     3121 gtttcagaag tcaataggaa gcagggtgag acaagtgcgt cacagtagtg atcctgccaa
     3181 tgatcctttt caaatgtgac agctgctgac agacggctac agatcaaagg gaacacatag
     3241 cacatgacat cccaattcta tccaatacac agtagggcca cgattaggca acttcaggat
     3301 atttccctgc ttcctgatca agatttttag cttcatattg gaaactatat tacatagata
     3361 agaggaattt gttttgtgtg aagtagcaaa agaaaaacca ttatagatct aaaaagcaat
     3421 gttttgttcc ttcactgggg aagagttaag cctatagttc tacaaatatg taatgctatg
     3481 ctgcttcttt taccttcctg acctgagcat atttacccag ttaagcagtt aatgtcacca
     3541 ctccaaaaca aacaaacaaa aaaaaaaaca gaaaaaaagg aaaaaaggaa agaaagatag
     3601 aaaatagcat tattatcata agtgacctgg ttaaaggaag cataatttca tttggctcag
     3661 tcctggataa ctttcaaagc acatatccat atggccagaa aaatattgga tgcagactat
     3721 attcttgaag tgacatgtat gtaatcaata taaagaaagt ctctatactt ttcacatttt
     3781 gagaggatct tgaggaaggt cttctttagg ttatattgta agatatgtac aaggattctg
     3841 ggatttcttc cttttagtat tgtgggtctg accctcaaaa gcctagcttt gttaaatatt
     3901 tgaaaatatg aagaacttta atactattaa attggccttt atttctaaaa tttttcatag
     3961 actcttttgc aaattgagtg tcaatacttc taaacccatt tatcctttgc cagtgggtag
     4021 gaactgagtt gtagatttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt aagattgaat
     4081 agttgcctgc tttgagttag attttattca attatcatga cgattatcac aaatgtttta
     4141 caaatttaat ttacatttaa agactaattc atttctagta atttgtatca acctcaacta
     4201 aactctatca aaatttcaac tcttgaaaaa ttaaatgctt tcttcttaca ataaagaaag
     4261 ttaaagtgga aa
//
LOCUS       NM_001436776            3499 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 2, mRNA.
ACCESSION   NM_001436776 XM_039094339
VERSION     NM_001436776.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039094339.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50360.1,
                                           SRR26643285.50322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1162           JAXUCZ010000016.1  19544907-19545047
            1163-1330           JAXUCZ010000016.1  19545142-19545309
            1331-1610           JAXUCZ010000016.1  19546706-19546985
            1611-1912           JAXUCZ010000016.1  19548553-19548854
            1913-1987           JAXUCZ010000016.1  19549511-19549585
            1988-2180           JAXUCZ010000016.1  19549883-19550075
            2181-3499           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3499
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2311
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 1 is encoded by transcript variant 2; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 1"
                     /protein_id="NP_001423705.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQQIHNIRQHSSTGPPPLLLAPRASVP
                     SMQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVV
                     ASAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEV
                     VQNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKK
                     ALKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRK
                     LAFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTG
                     RHSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPR
                     SIPQSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1667..1768
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1667..1768
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1162
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1330
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1610
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1912
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1987
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2180
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..3499
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc caggtgagtc agcagattca caacatcaga cagcattcct ccacggggcc
     1201 accacccctc ctcctggccc cccgtgcctc agtgcccagc atgcagattc agggacagag
     1261 gatcatccag cagggactca tccgggtcgc caatgtcccc aacaccagtc tgctcgtcaa
     1321 tatccctcag cctacggcag cctcactgaa ggggacaaca gttggctctg ctcaggcaaa
     1381 ctccactccc agcagtgtgg cttctgtggt tgcctctgct gagtccccag ctagccggca
     1441 ggctgctgcc aagctagcgc tgcgcaagca gttggagaag acactgctgg agatcccccc
     1501 acccaagccc cctgctccgg agatgaactt cttgcccagt gctgccaaca atgaattcat
     1561 ctatctggtc ggcttggagg aagtggtgca gaacctgctg gagacgcaag cgggcaggat
     1621 ttctgccacc tcagctgctg ccgtgttatc ccgggagcct tacatgtgtg tgcagtgtaa
     1681 gacagacttc acatgccgct ggcgagagaa gggtggagct gtcatgtgtg agaactgcat
     1741 gacatccaac caaaagaagg cactaaaagt ggagcacacc agtcgcctga aggccgcctt
     1801 cgtgaaggcg ctacaacaag agcaggagat ggagcagcga ctgctgcagc agggcgtagg
     1861 caccgccagc atcaaggctg agaccgcagc tccacatccc tcgctgaagc aggtcataaa
     1921 gccccgacgt aagttggcgt tccgctcagg agaggcccgt gactggaata acgggtccgt
     1981 actacagact tccagccagc tgtcccgggg ttcagccaca acacctcgtg gtgttctgca
     2041 cactttcagc cagtcaccca aactgcagaa cgcagcctca gctacggccc tggtaagcag
     2101 gactggcaga cattccgaga gagtcgtggg caccagcaag ggcaccgcct ccaactggaa
     2161 aaagacacct ctgagcacag gtgggacgct tgccttcgtc agcccaagct tggcagtgca
     2221 caagagctcc tcggccgtgg accgacagcg agagtacctc ctggacatga ttcctccacg
     2281 ctccatcccc cagtcagcca catggaaata gtgggagccg gcccagccga ggacaggccc
     2341 tctgctctcc cgaggccctt ggtctaggac acgcagacta ccctcctagc aagttgcctg
     2401 agacagctca ggccttggct cttgccttgc tgtggccagg agagtaccac catggtgccc
     2461 aggatcagaa ccagggacct tccctatggg ccttctcctt cctttttgcc tttagtttgc
     2521 ccgacaccag cagaaactcg gaccttgggg ccagctctgc ctggccagcg tgggtgggag
     2581 ctcaccctgg acactgtgac acacccgggc cagactggca ccgggggctc ccgaagttga
     2641 gccgggattt cgttttcttt tggcttttcc catcttagct ccccagtctc tgcctcttca
     2701 tggccatcta taggttgaag tttgggtttt attgggtttt ttgtttttgt tttttttata
     2761 atcacctcat aatgatgatg gaattaaagt gaactgcata gacccagggt catggttgtg
     2821 cacagtgcag tctggcaggc tctaccccag aggatgctca gagtggcagc agcagagatg
     2881 gcaggtgcca ccctggctct ggtcgtgttt gttgctgctc actgcagtcc ctggcttcca
     2941 cacttagcag aatgaaccgc agcccagatc tgtctgacat ccagaggctc cagagggatg
     3001 ctggggtccg ccatgctgga gtcagagctg actgctggct gggaggctgc tgggttactt
     3061 ttcgtggttt attttattaa aaatttctat cctttttctc ttcattttga tggacacaat
     3121 ctcaagatgc ccatgcctgc caagaggcat ccaagtaggg cccagccaga acccttaggt
     3181 ctggagtcag cagggcttac tccctcttag ccacagggat gtctgaaagg gctgagtcta
     3241 cttttgttct gttttgtttc cttctccctc cactcttaac aatgggttcc atggtgaaag
     3301 gcagaagcag ctctgtgtcc agcacgcacg gtgcggcctt ctgctcatgt gattggtcgc
     3361 cgtcgtttcc ccatccagcc ctggtttccc ttgacacaat acagttaggg actttaattt
     3421 aaacccttgt tctgcagacc atcgccctct gcagacatgc ccctgcctcc tcctaataaa
     3481 ggctcattta actccgtga
//
LOCUS       NM_001436777            3496 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 3, mRNA.
ACCESSION   NM_001436777 XM_063275194
VERSION     NM_001436777.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3496)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3496)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3496)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275194.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55837.1,
                                           SRR26643298.71134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1162           JAXUCZ010000016.1  19544907-19545047
            1163-1327           JAXUCZ010000016.1  19545145-19545309
            1328-1607           JAXUCZ010000016.1  19546706-19546985
            1608-1909           JAXUCZ010000016.1  19548553-19548854
            1910-1984           JAXUCZ010000016.1  19549511-19549585
            1985-2177           JAXUCZ010000016.1  19549883-19550075
            2178-3496           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3496
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2308
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 2 is encoded by transcript variant 3; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 2"
                     /protein_id="NP_001423706.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKL
                     AFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGR
                     HSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRS
                     IPQSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1664..1765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1664..1765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1162
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1327
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1607
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1909
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1984
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2177
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..3496
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc caggtgagtc agattcacaa catcagacag cattcctcca cggggccacc
     1201 acccctcctc ctggcccccc gtgcctcagt gcccagcatg cagattcagg gacagaggat
     1261 catccagcag ggactcatcc gggtcgccaa tgtccccaac accagtctgc tcgtcaatat
     1321 ccctcagcct acggcagcct cactgaaggg gacaacagtt ggctctgctc aggcaaactc
     1381 cactcccagc agtgtggctt ctgtggttgc ctctgctgag tccccagcta gccggcaggc
     1441 tgctgccaag ctagcgctgc gcaagcagtt ggagaagaca ctgctggaga tccccccacc
     1501 caagccccct gctccggaga tgaacttctt gcccagtgct gccaacaatg aattcatcta
     1561 tctggtcggc ttggaggaag tggtgcagaa cctgctggag acgcaagcgg gcaggatttc
     1621 tgccacctca gctgctgccg tgttatcccg ggagccttac atgtgtgtgc agtgtaagac
     1681 agacttcaca tgccgctggc gagagaaggg tggagctgtc atgtgtgaga actgcatgac
     1741 atccaaccaa aagaaggcac taaaagtgga gcacaccagt cgcctgaagg ccgccttcgt
     1801 gaaggcgcta caacaagagc aggagatgga gcagcgactg ctgcagcagg gcgtaggcac
     1861 cgccagcatc aaggctgaga ccgcagctcc acatccctcg ctgaagcagg tcataaagcc
     1921 ccgacgtaag ttggcgttcc gctcaggaga ggcccgtgac tggaataacg ggtccgtact
     1981 acagacttcc agccagctgt cccggggttc agccacaaca cctcgtggtg ttctgcacac
     2041 tttcagccag tcacccaaac tgcagaacgc agcctcagct acggccctgg taagcaggac
     2101 tggcagacat tccgagagag tcgtgggcac cagcaagggc accgcctcca actggaaaaa
     2161 gacacctctg agcacaggtg ggacgcttgc cttcgtcagc ccaagcttgg cagtgcacaa
     2221 gagctcctcg gccgtggacc gacagcgaga gtacctcctg gacatgattc ctccacgctc
     2281 catcccccag tcagccacat ggaaatagtg ggagccggcc cagccgagga caggccctct
     2341 gctctcccga ggcccttggt ctaggacacg cagactaccc tcctagcaag ttgcctgaga
     2401 cagctcaggc cttggctctt gccttgctgt ggccaggaga gtaccaccat ggtgcccagg
     2461 atcagaacca gggaccttcc ctatgggcct tctccttcct ttttgccttt agtttgcccg
     2521 acaccagcag aaactcggac cttggggcca gctctgcctg gccagcgtgg gtgggagctc
     2581 accctggaca ctgtgacaca cccgggccag actggcaccg ggggctcccg aagttgagcc
     2641 gggatttcgt tttcttttgg cttttcccat cttagctccc cagtctctgc ctcttcatgg
     2701 ccatctatag gttgaagttt gggttttatt gggttttttg tttttgtttt ttttataatc
     2761 acctcataat gatgatggaa ttaaagtgaa ctgcatagac ccagggtcat ggttgtgcac
     2821 agtgcagtct ggcaggctct accccagagg atgctcagag tggcagcagc agagatggca
     2881 ggtgccaccc tggctctggt cgtgtttgtt gctgctcact gcagtccctg gcttccacac
     2941 ttagcagaat gaaccgcagc ccagatctgt ctgacatcca gaggctccag agggatgctg
     3001 gggtccgcca tgctggagtc agagctgact gctggctggg aggctgctgg gttacttttc
     3061 gtggtttatt ttattaaaaa tttctatcct ttttctcttc attttgatgg acacaatctc
     3121 aagatgccca tgcctgccaa gaggcatcca agtagggccc agccagaacc cttaggtctg
     3181 gagtcagcag ggcttactcc ctcttagcca cagggatgtc tgaaagggct gagtctactt
     3241 ttgttctgtt ttgtttcctt ctccctccac tcttaacaat gggttccatg gtgaaaggca
     3301 gaagcagctc tgtgtccagc acgcacggtg cggccttctg ctcatgtgat tggtcgccgt
     3361 cgtttcccca tccagccctg gtttcccttg acacaataca gttagggact ttaatttaaa
     3421 cccttgttct gcagaccatc gccctctgca gacatgcccc tgcctcctcc taataaaggc
     3481 tcatttaact ccgtga
//
LOCUS       NM_001436798            4718 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 3, mRNA.
ACCESSION   NM_001436798
VERSION     NM_001436798.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4718)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4718)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4718)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.19794.1,
                                           SRR26643290.19817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  123105380-123105468
            90-190              JAXUCZ010000005.1  123106498-123106598
            191-264             JAXUCZ010000005.1  123109161-123109234
            265-289             JAXUCZ010000005.1  123118303-123118327
            290-435             JAXUCZ010000005.1  123122432-123122577
            436-597             JAXUCZ010000005.1  123130554-123130715
            598-730             JAXUCZ010000005.1  123131303-123131435
            731-795             JAXUCZ010000005.1  123132010-123132074
            796-868             JAXUCZ010000005.1  123134055-123134127
            869-1020            JAXUCZ010000005.1  123138897-123139048
            1021-1102           JAXUCZ010000005.1  123139751-123139832
            1103-1197           JAXUCZ010000005.1  123141269-123141363
            1198-1325           JAXUCZ010000005.1  123146672-123146799
            1326-1465           JAXUCZ010000005.1  123150654-123150793
            1466-4718           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4718
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..89
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            90..190
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="upstream in-frame stop codon"
     exon            191..264
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1794
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform b is encoded by transcript variant 3;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform b"
                     /protein_id="NP_001423727.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MFMFNWFTDCLWILFLSNYKPSVESSSPGGSAASEDHEFDPSAD
                     MLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEE
                     EEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQD
                     AQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKE
                     NEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYE
                     LVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRT
                     RSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRA
                     PSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGN
                     KKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGS
                     SEFFQEAVSHGKFEEHENTND"
     misc_feature    799..948
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    799..948
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1117..1251
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1117..1251
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1117..1119,1207..1212,1216..1221,1225..1233,
                     1237..1245)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1117..1119,1207..1212,1216..1221,1225..1233,
                     1237..1245)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1279..>1719
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1279..>1719
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            265..289
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            290..435
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            436..597
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            598..730
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            731..795
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            796..868
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1020
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1102
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1197
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1325
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1465
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..4718
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgag tctcccggct gcaggcggat ggatggggcg tctccaggcg gcggcggcag
       61 cagcggaggc ggcggtagcg gcggcggcta tggtgtggtg gctcgattct cccagtgcct
      121 ggctgagttt cggacgtggt taagaaccaa ctggttgagg ttcaatgcag acaagacgga
      181 tgtgatgctg aaaatgtgca tcagatgttt atgtttaatt ggtttacaga ctgtctctgg
      241 attcttttcc tgtcaaatta caagccatct gttgagtctt caagtccagg gggctcagca
      301 gcgtcagagg accatgagtt tgatccgtca gctgacatgc tggttcatga ttttgatgat
      361 gagcgaacat tagaagaaga agaaatgatg gaaggagaga caaacttcag ttctgaaata
      421 gaggatcttg cgagggaagg cgacatgcca atcgacgagc ttctcagcct ctatggttat
      481 ggcagcactg ttcagttacc tgaagaggag gaggaggagg aagaagagga ggaagaaggt
      541 gaagatgatg aagatgcgga caatgatgac aacagtggct gcagtgggga aaataaagaa
      601 gagaatataa aggattcatc gggtcaggag gatgaaactc agtcttccaa tgatgatccc
      661 tcacagtctg ttacttccca agatgctcag gaaataatcc gcccacgtcg atgtaaatat
      721 tttgatacaa atagtgaaat agaagaagaa tctgaagaag atgaagatta tattccctca
      781 gaagactgga aaaaggaaat catggtaggc tccatgtttc aagctgagat tccagttggc
      841 gtttgtagat acaaagaaaa tgaaaaagtg tatgaaaatg atgatcagct tctgtgggat
      901 ccagaatatt taccagaaga taaagtgatt gtctttctta aggatgcatc tagaagaaca
      961 ggggatgaga aaggtgtaga agcaattcct gaaggatctc atataaaaga caatgaacag
     1021 gctttatatg aattggttaa atgcagtttt gatacagaag aagccttgag aagactgaga
     1081 tttaatgtca aagcagctcg agaggaatta tctgtgtgga cagaggaaga atgtagaaat
     1141 tttgaacaag ggctgaaggc ctatgggaaa gattttcatc tgattcaggc taataaagtc
     1201 cgaacaagat cagttggtga atgtgtagca ttctattaca tgtggaaaaa gtctgagcgt
     1261 tatgatttct ttgctcagca aacaaggttt ggaaaaaaga aatataatct tcatcctggt
     1321 gtaacggatt acatggatcg tcttttggat gaaagtgaaa gtgctgcttc tagccgagca
     1381 ccatcccctc ctcccaccgc ctcaaacagt agtaccagcc agtcggagaa agaagacggc
     1441 acgctcagca atagcaatca gaatggtgtg tcatctaatg gaccaggaga aatactaaac
     1501 aaagaagaag taaaagttga aggcttacat gttaatggac caacaggtgg aaataagaaa
     1561 ccacttctta cagatgtgga cactaatggt tacgaagaaa ataaccttgc cactgaccca
     1621 aaacttgccc atatgactgc aagaaatgaa aatgattttg atgaaaaaaa tgagagacct
     1681 gccaaaaggc ggcggataaa cagcagtggg aaagaaagtc cgggttcgtc tgagtttttc
     1741 caggaagcag tctcacatgg gaagtttgag gaacatgaaa acacaaatga ctaactctta
     1801 ggcctatttt actttctttg cagtaaagtc tggtttgact acaattttca gggttggggg
     1861 ggtgaccttt agaaagctga tttccttgaa gcagttgtta actcttgaaa ttggaattag
     1921 gtcctaactt taagaaatgg gattcataat tctacttttt gcaagttctt ttacttcaaa
     1981 ttttgaagcc ctctttaagg atataaaaac attggtaaat ttgaatgacc caaagactta
     2041 actgcacctt ctcctttgag aaacaagtca tatttgacta aaaggtaatc tttccttatt
     2101 ctttatgagg aagaaaaaag tttgtttctg ttcaacacca atttttttta ttatctagaa
     2161 atgtctttac aacagacatt tttctctcca tacaaattga acatcgtcat taaggaaacc
     2221 ctcatgaatc ctgaaggtta tgctagcatg atttttatat gtagaagttt aaaaataaac
     2281 caagtcaggt ttgtatttgt aaaattgttg acatcaatga tgtctttcca tattcttatc
     2341 tgggcttaag aaatacattc tgtatttttc cagattcttt gtagcctttg aaagattttt
     2401 acagtacata tgtcttgact gagctgtcct ttcttaatac aaaaaaagct tgtataattt
     2461 tcttaacttg tacagttggt aaacttttat gagaggaact gatattctga gtctgtcagc
     2521 tttcatttta ttttgctaag atttttctaa tgaattttta agtgtgtgtg tagttaacca
     2581 agtcatgttt cttatccagg tggtaaaagc attcataaag aattatgtta ttttcaaact
     2641 tctacttact gacataattt gggacttcta aatttcagca tgatactcag attacaagct
     2701 tgtttgcatt tgctataatt ttataaatta attgtgaaac aaaacaaaga cttactgtca
     2761 gcttaagtgt gtagatgtat cgtgctgaat agaatcctgt tcagttactc tcatgtgccc
     2821 tacaagattt ctcattgttt cagtcaacag aaagggaagg tcacgtgatg ttgcaatatt
     2881 gccacatcca aggagtaact gttgacaggt agcaatattc atttttatga gaaaatagtg
     2941 gttttaagaa ttttcagatc tttccagttg taatccagtt tgtcacattt gatacttttt
     3001 ccaaaatgaa acacatacaa aataaccatt gttctgtgtg actttaaaaa gggttattgc
     3061 actagccttg taagaatgga tgccatttta ttgttagtgc aaaattcttc ttacaaaatg
     3121 tagttttata cagctgatag accaatctat ctctggactg ttttttagtg aatgatgatt
     3181 aactaccttt tctcacacag gcacatcccc aaatgctgcc ttcagtttga tctcagccgt
     3241 cagttcaaga gccactgctt tcaaagacag atctgtgtcc ttttagtggc tcagttgtct
     3301 gatgcagggt gggttaaggt ttgcactgag aatgatcgcc caggcctctc cctcatagta
     3361 ttcttacatt tgtccagact gcttcccttc acaatgggta caaacttttc tttccccaaa
     3421 tcagtattag aagccacctt gacagcacat cataataata cgcatttact gttttctgca
     3481 gaaatagtcc agtgagttgc cttcaggtgg aagtgctgag aagcacgaga gggtttagtt
     3541 tgttttattg aaaacattaa tttatccaga atggcagtag gtcaagtacc tttagcagat
     3601 ggtcatagct tgtctccctg cccaccccca cagagtctca ctgtgtagcc caggctggcc
     3661 tggaacttaa caacccttct acctcagccc gctaatgctg agattggagg tgtttcccac
     3721 cacacccagc aacagtctat tttctaaagc aggttttatt atatgagtcc aggccatccc
     3781 agctccttgt cacaggtgat ctttaagtga tgctatgctt tttaatcatt acactatgga
     3841 agatgtcagt ccgcctttta aaggatgcct ctgctcgaca cgttcttgga cttctcgaaa
     3901 ctgttgtaac aggaacgttt taaggaaatt ctcaggcatg ttggcaaatg tgccaggtgt
     3961 ataagtgttc ataaatcttt tctttttaaa gtatgcataa tgaaacattc ctctaataca
     4021 caaggctcag cttttcccaa ctatattctg tgtttgtata ggtatttcac cctttgttca
     4081 aaaaatgcag ccactgaaac ttaagtcatt gcacttttaa acagtttgac aatatcatga
     4141 gtaatctgct taagatttgg tgtatttcct aactgttgaa cacttaagta actgagatga
     4201 gaaaataagc attcatgagt agggatgtag ctcagttgct ggaatgctta cccaacatgc
     4261 atgcaaaatg ggttccatcc ccagtaccac aggaactggg tatagtggtg catgcctgtc
     4321 atcctaagca cttgggaggt ggaggcagga gaatcagaag ttcaaggcca tcctcattac
     4381 ctggtgagtt gaggccagcc tgatatgctg actcagatag aaatggctct gttggtagtt
     4441 attaggtcct agccaagcac tgtcattttc atctggaaca tacaatgatg atgtatttat
     4501 gatgtattct cactaaggtt cacaatctgt aactcagttc aacacagatc tcttgagctt
     4561 taaaaggtat ttgaagtaat ttaagtaggc attcaaaatt atgaattaga tgtttttaaa
     4621 tttctgcata ataattttgc actgtaaaat atgtcctttc tcccatttcc ttctgccatt
     4681 ctgatatgct cattaaaata tttttgtaag catactca
//
LOCUS       NM_001131012            4576 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 4, mRNA.
ACCESSION   NM_001131012 XM_001058293 XM_233245
VERSION     NM_001131012.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4576)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4576)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4576)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001131012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168252.1, SRR26360194.741127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000005.1  123110307-123110428
            123-147             JAXUCZ010000005.1  123118303-123118327
            148-293             JAXUCZ010000005.1  123122432-123122577
            294-455             JAXUCZ010000005.1  123130554-123130715
            456-588             JAXUCZ010000005.1  123131303-123131435
            589-653             JAXUCZ010000005.1  123132010-123132074
            654-726             JAXUCZ010000005.1  123134055-123134127
            727-878             JAXUCZ010000005.1  123138897-123139048
            879-960             JAXUCZ010000005.1  123139751-123139832
            961-1055            JAXUCZ010000005.1  123141269-123141363
            1056-1183           JAXUCZ010000005.1  123146672-123146799
            1184-1323           JAXUCZ010000005.1  123150654-123150793
            1324-4576           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4576
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..122
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    93..95
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="upstream in-frame stop codon"
     CDS             114..1652
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform c is encoded by transcript variant 4;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform c"
                     /protein_id="NP_001124484.2"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MAEPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEM
                     MEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDAD
                     NDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNS
                     EIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEY
                     LPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRF
                     NVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSE
                     RYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEK
                     EDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENN
                     LATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHE
                     NTND"
     misc_feature    657..806
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    657..806
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    975..1109
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    975..1109
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(975..977,1065..1070,1074..1079,1083..1091,
                     1095..1103)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(975..977,1065..1070,1074..1079,1083..1091,
                     1095..1103)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1137..>1577
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1137..>1577
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            123..147
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            148..293
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            294..455
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            456..588
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            589..653
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            654..726
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            727..878
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            879..960
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1055
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1183
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1323
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..4576
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttcccgc cgaagcggcg gcggagacag cagcgggagc cccgcggccc aggcgcacat
       61 ccgggttctg gccacgaccc gccgcggcga tgtgacccgg tggcgcggcc aacatggcgg
      121 agccatctgt tgagtcttca agtccagggg gctcagcagc gtcagaggac catgagtttg
      181 atccgtcagc tgacatgctg gttcatgatt ttgatgatga gcgaacatta gaagaagaag
      241 aaatgatgga aggagagaca aacttcagtt ctgaaataga ggatcttgcg agggaaggcg
      301 acatgccaat cgacgagctt ctcagcctct atggttatgg cagcactgtt cagttacctg
      361 aagaggagga ggaggaggaa gaagaggagg aagaaggtga agatgatgaa gatgcggaca
      421 atgatgacaa cagtggctgc agtggggaaa ataaagaaga gaatataaag gattcatcgg
      481 gtcaggagga tgaaactcag tcttccaatg atgatccctc acagtctgtt acttcccaag
      541 atgctcagga aataatccgc ccacgtcgat gtaaatattt tgatacaaat agtgaaatag
      601 aagaagaatc tgaagaagat gaagattata ttccctcaga agactggaaa aaggaaatca
      661 tggtaggctc catgtttcaa gctgagattc cagttggcgt ttgtagatac aaagaaaatg
      721 aaaaagtgta tgaaaatgat gatcagcttc tgtgggatcc agaatattta ccagaagata
      781 aagtgattgt ctttcttaag gatgcatcta gaagaacagg ggatgagaaa ggtgtagaag
      841 caattcctga aggatctcat ataaaagaca atgaacaggc tttatatgaa ttggttaaat
      901 gcagttttga tacagaagaa gccttgagaa gactgagatt taatgtcaaa gcagctcgag
      961 aggaattatc tgtgtggaca gaggaagaat gtagaaattt tgaacaaggg ctgaaggcct
     1021 atgggaaaga ttttcatctg attcaggcta ataaagtccg aacaagatca gttggtgaat
     1081 gtgtagcatt ctattacatg tggaaaaagt ctgagcgtta tgatttcttt gctcagcaaa
     1141 caaggtttgg aaaaaagaaa tataatcttc atcctggtgt aacggattac atggatcgtc
     1201 ttttggatga aagtgaaagt gctgcttcta gccgagcacc atcccctcct cccaccgcct
     1261 caaacagtag taccagccag tcggagaaag aagacggcac gctcagcaat agcaatcaga
     1321 atggtgtgtc atctaatgga ccaggagaaa tactaaacaa agaagaagta aaagttgaag
     1381 gcttacatgt taatggacca acaggtggaa ataagaaacc acttcttaca gatgtggaca
     1441 ctaatggtta cgaagaaaat aaccttgcca ctgacccaaa acttgcccat atgactgcaa
     1501 gaaatgaaaa tgattttgat gaaaaaaatg agagacctgc caaaaggcgg cggataaaca
     1561 gcagtgggaa agaaagtccg ggttcgtctg agtttttcca ggaagcagtc tcacatggga
     1621 agtttgagga acatgaaaac acaaatgact aactcttagg cctattttac tttctttgca
     1681 gtaaagtctg gtttgactac aattttcagg gttggggggg tgacctttag aaagctgatt
     1741 tccttgaagc agttgttaac tcttgaaatt ggaattaggt cctaacttta agaaatggga
     1801 ttcataattc tactttttgc aagttctttt acttcaaatt ttgaagccct ctttaaggat
     1861 ataaaaacat tggtaaattt gaatgaccca aagacttaac tgcaccttct cctttgagaa
     1921 acaagtcata tttgactaaa aggtaatctt tccttattct ttatgaggaa gaaaaaagtt
     1981 tgtttctgtt caacaccaat tttttttatt atctagaaat gtctttacaa cagacatttt
     2041 tctctccata caaattgaac atcgtcatta aggaaaccct catgaatcct gaaggttatg
     2101 ctagcatgat ttttatatgt agaagtttaa aaataaacca agtcaggttt gtatttgtaa
     2161 aattgttgac atcaatgatg tctttccata ttcttatctg ggcttaagaa atacattctg
     2221 tatttttcca gattctttgt agcctttgaa agatttttac agtacatatg tcttgactga
     2281 gctgtccttt cttaatacaa aaaaagcttg tataattttc ttaacttgta cagttggtaa
     2341 acttttatga gaggaactga tattctgagt ctgtcagctt tcattttatt ttgctaagat
     2401 ttttctaatg aatttttaag tgtgtgtgta gttaaccaag tcatgtttct tatccaggtg
     2461 gtaaaagcat tcataaagaa ttatgttatt ttcaaacttc tacttactga cataatttgg
     2521 gacttctaaa tttcagcatg atactcagat tacaagcttg tttgcatttg ctataatttt
     2581 ataaattaat tgtgaaacaa aacaaagact tactgtcagc ttaagtgtgt agatgtatcg
     2641 tgctgaatag aatcctgttc agttactctc atgtgcccta caagatttct cattgtttca
     2701 gtcaacagaa agggaaggtc acgtgatgtt gcaatattgc cacatccaag gagtaactgt
     2761 tgacaggtag caatattcat ttttatgaga aaatagtggt tttaagaatt ttcagatctt
     2821 tccagttgta atccagtttg tcacatttga tactttttcc aaaatgaaac acatacaaaa
     2881 taaccattgt tctgtgtgac tttaaaaagg gttattgcac tagccttgta agaatggatg
     2941 ccattttatt gttagtgcaa aattcttctt acaaaatgta gttttataca gctgatagac
     3001 caatctatct ctggactgtt ttttagtgaa tgatgattaa ctaccttttc tcacacaggc
     3061 acatccccaa atgctgcctt cagtttgatc tcagccgtca gttcaagagc cactgctttc
     3121 aaagacagat ctgtgtcctt ttagtggctc agttgtctga tgcagggtgg gttaaggttt
     3181 gcactgagaa tgatcgccca ggcctctccc tcatagtatt cttacatttg tccagactgc
     3241 ttcccttcac aatgggtaca aacttttctt tccccaaatc agtattagaa gccaccttga
     3301 cagcacatca taataatacg catttactgt tttctgcaga aatagtccag tgagttgcct
     3361 tcaggtggaa gtgctgagaa gcacgagagg gtttagtttg ttttattgaa aacattaatt
     3421 tatccagaat ggcagtaggt caagtacctt tagcagatgg tcatagcttg tctccctgcc
     3481 cacccccaca gagtctcact gtgtagccca ggctggcctg gaacttaaca acccttctac
     3541 ctcagcccgc taatgctgag attggaggtg tttcccacca cacccagcaa cagtctattt
     3601 tctaaagcag gttttattat atgagtccag gccatcccag ctccttgtca caggtgatct
     3661 ttaagtgatg ctatgctttt taatcattac actatggaag atgtcagtcc gccttttaaa
     3721 ggatgcctct gctcgacacg ttcttggact tctcgaaact gttgtaacag gaacgtttta
     3781 aggaaattct caggcatgtt ggcaaatgtg ccaggtgtat aagtgttcat aaatcttttc
     3841 tttttaaagt atgcataatg aaacattcct ctaatacaca aggctcagct tttcccaact
     3901 atattctgtg tttgtatagg tatttcaccc tttgttcaaa aaatgcagcc actgaaactt
     3961 aagtcattgc acttttaaac agtttgacaa tatcatgagt aatctgctta agatttggtg
     4021 tatttcctaa ctgttgaaca cttaagtaac tgagatgaga aaataagcat tcatgagtag
     4081 ggatgtagct cagttgctgg aatgcttacc caacatgcat gcaaaatggg ttccatcccc
     4141 agtaccacag gaactgggta tagtggtgca tgcctgtcat cctaagcact tgggaggtgg
     4201 aggcaggaga atcagaagtt caaggccatc ctcattacct ggtgagttga ggccagcctg
     4261 atatgctgac tcagatagaa atggctctgt tggtagttat taggtcctag ccaagcactg
     4321 tcattttcat ctggaacata caatgatgat gtatttatga tgtattctca ctaaggttca
     4381 caatctgtaa ctcagttcaa cacagatctc ttgagcttta aaaggtattt gaagtaattt
     4441 aagtaggcat tcaaaattat gaattagatg tttttaaatt tctgcataat aattttgcac
     4501 tgtaaaatat gtcctttctc ccatttcctt ctgccattct gatatgctca ttaaaatatt
     4561 tttgtaagca tactca
//
LOCUS       NM_001436774            1937 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 7, mRNA.
ACCESSION   NM_001436774 XM_017593366
VERSION     NM_001436774.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017593366.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.15199.1,
                                           SRR22399489.1781504.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1253           JAXUCZ010000005.1  102900532-102900650 c
            1254-1937           JAXUCZ010000005.1  102898944-102899627 c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1937
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1266
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 7 is encoded by transcript variant 7; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 7"
                     /protein_id="NP_001423703.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEHFAL"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    <535..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="DNA topoisomerase 2-like protein; Provisional;
                     Region: PTZ00108"
                     /db_xref="CDD:240271"
     misc_feature    <535..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="DNA topoisomerase 2-like protein; Provisional;
                     Region: PTZ00108"
                     /db_xref="CDD:240271"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1253
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1937
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagaagaga
     1141 aagggtggaa gaaacttcca ggctgctcac aggaggaaca tgctaaaagg ccaacatgag
     1201 aaagaagctg cagatcggaa acgcaagcag gaggaacaaa tggagactga gcattttgct
     1261 ctgtaaagca tttcagatgc aacttgtgtg aaatgcatta tgcaaaataa agtttattgt
     1321 attgtattcc cagccaaaca acatgtaatc tacagtaata aaaatatatc tcattttggg
     1381 ctcaaagcat taatccagta actgaaaaga gaatacgagt ggagcataca agcgatgaag
     1441 atcttgagac agactcattg gactgaattt tcccctcccc ccttgatgga agaaatgttc
     1501 cagattctaa attgaggact tcactattaa tggcattatt aactgtgtta tgattgttaa
     1561 caaaatatcc tgtaaggtac acactacata ttaaggttgg ccatcattcc tgtttttttt
     1621 tttagccaag cttaaaatga agctttgtgt ttgaagttat aacaaacata gatgaagtcg
     1681 gtggttgtac attatttcat ttagaaaata tgaaaactca ttttgttttg aagataggta
     1741 ttaaactgaa atagctatta cgttcttgaa aaatggggca ggtgtgccct tcccttgaca
     1801 ttcttttgtt gttaagttct ttagagtctt gttttttttt ttctttttaa tcctgagaga
     1861 ttaaacagta gacttgttaa gtaaaaatat gaaactgtaa ccaaaatttt aaaataaagt
     1921 tttttttaaa aaaaaaa
//
LOCUS       NM_001436831            1363 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus C1q and TNF related 7 (C1qtnf7), transcript
            variant 3, mRNA.
ACCESSION   NM_001436831 XM_039091942
VERSION     NM_001436831.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Bi,J., Duan,Y., Wang,M., He,C., Li,X., Zhang,X., Tao,Y., Du,Y. and
            Liu,H.
  TITLE     Deletion of large-conductance calcium-activated potassium channels
            promotes vascular remodelling through the CTRP7-mediated PI3K/Akt
            signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (12), 1-11 (2022)
   PUBMED   36514218
  REMARK    GeneRIF: Deletion of large-conductance calcium-activated potassium
            channels promotes vascular remodelling through the CTRP7-mediated
            PI3K/Akt signaling pathway.
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Rohrbach,S., Aurich,A.C., Li,L. and Niemann,B.
  TITLE     Age-associated loss in adiponectin-activation by caloric
            restriction: lack of compensation by enhanced inducibility of
            adiponectin paralogs CTRP2 and CTRP7
  JOURNAL   Mol Cell Endocrinol 277 (1-2), 26-34 (2007)
   PUBMED   17716811
  REMARK    GeneRIF: The purpose of the current study was to investigate
            age-dependent effects of caloric restriction on the release of
            adiponectin, expression and activation of adiponectin-related
            signaling and on parameters of altered insulin sensitivity.
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039091942.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35039.1,
                                           SRR26643299.54756.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000014.1  71792727-71792877   c
            152-397             JAXUCZ010000014.1  71686790-71687035   c
            398-1363            JAXUCZ010000014.1  71680478-71681443   c
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1363
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q and TNF related 7"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
     exon            1..151
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    151..153
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="upstream in-frame stop codon"
     exon            152..397
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1029
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; complement C1q tumor necrosis factor-related
                     protein 7; C1q and tumor necrosis factor related protein
                     7; adiponectin g"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 7 isoform 1 precursor"
                     /protein_id="NP_001423760.1"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
                     /translation="MIVLLYVTSLAICASGQPRGNQAKGESYSPRYICSIPGLPGPPG
                     PPGANGSPGPHGRIGLPGRDGRDGRKGEKGEKGTAGLKGKTGPLGLAGEKGDQGETGK
                     KGPIGPEGEKGEVGPAGPPGPKGDRGDQGDPGLPGVCRCGSIVLKSAFSVGITTSYPE
                     ERLPIIFNKVLFNEGEHYNPATGKFICAFPGIYYFSYDITLANKHLAIGLVHNGQYRI
                     RTFDANTGNHDVASGSTVIYLQPEDEVWLEIFFNDQNGLFSDPGWADSLFSGFLLYVD
                     TDYLDSISEDDEL"
     sig_peptide     160..207
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <325..>570
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <325..>570
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    604..978
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     misc_feature    604..978
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     exon            398..1363
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtgcacc cagcgatggc tgcagagaga cggaaaatcc tccagatacc tgaggctctt
       61 gctttgcgtc tgcctctgtc tgcggtttgc agaagaacct tgcccactcc tcctcattcg
      121 taacgagtgt atatagtaaa ctctttgaaa tagcccaaga tgattgtcct gctctacgtg
      181 acaagtcttg ccatctgtgc aagtggacaa cctcggggca atcaggctaa gggggagagc
      241 tactctccaa ggtacatctg cagcatccct ggcttacctg ggcccccagg tcctcctgga
      301 gcaaatggct cccctggacc ccatggtcgc attggccttc ctggaaggga tggtagagat
      361 ggcagaaaag gagagaaggg ggaaaagggc actgcaggtc taaaaggtaa gactggaccc
      421 ctgggccttg ctggtgagaa aggagaccaa ggagagactg ggaagaaagg acccatagga
      481 ccagagggtg agaaaggaga agttggtcca gctgggcctc ctgggccaaa gggagaccga
      541 ggagatcaag gggacccagg actgcctgga gtgtgcagat gtggaagcat cgtgctcaaa
      601 tctgcctttt cagttggcat cacaaccagc tacccagaag aaagactacc catcatattt
      661 aacaaagtcc tcttcaatga gggggagcac tacaaccctg caacagggaa gttcatttgt
      721 gctttcccag ggatctatta tttttcttat gatatcacgt tggccaataa gcacctagcc
      781 atcgggctgg tgcacaatgg gcagtaccgg ataaggacct ttgatgccaa cacagggaac
      841 cacgatgtgg cttcagggtc cacagtcatc tacctgcagc cagaagatga ggtctggctg
      901 gagattttct tcaatgacca gaatggcctc ttctcagatc caggctgggc agacagcttg
      961 ttctccgggt ttctcctcta tgttgataca gattacctgg attctatatc agaagacgat
     1021 gagttgtgat ccggactgca ggcctgaatg ttgcaacatg agttccacag tggcttacac
     1081 tctgatctaa tctggagtgc tggaaggtgg agcaagtgat actgggattc agaacacatt
     1141 ttttttacag atggctctgg cagagttaac aaaataagac aaaccaccaa ccagttgaaa
     1201 tcacaccaaa atgaacggca tgcaataacc ccagacatgg accccctgaa gtaaagatcc
     1261 taaatattta agcaaattaa gatgatgtta acaaatttga atgcccttgg caatacaacc
     1321 agcgggtagt gacactgcct cattaaatat tcataaaact cca
//
LOCUS       NM_001013881            3490 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 7, mRNA.
ACCESSION   NM_001013881 XM_214308
VERSION     NM_001013881.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001013881.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74318.1,
                                           SRR26643296.35378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1153           JAXUCZ010000016.1  19544907-19545038
            1154-1321           JAXUCZ010000016.1  19545142-19545309
            1322-1601           JAXUCZ010000016.1  19546706-19546985
            1602-1903           JAXUCZ010000016.1  19548553-19548854
            1904-1978           JAXUCZ010000016.1  19549511-19549585
            1979-2171           JAXUCZ010000016.1  19549883-19550075
            2172-3490           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3490
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2302
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 3 is encoded by transcript variant 7; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 3"
                     /protein_id="NP_001013903.2"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQQIHNIRQHSSTGPPPLLLAPRASVPSMQ
                     IQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASA
                     ESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQN
                     LLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALK
                     VEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAF
                     RSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHS
                     ERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIP
                     QSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1658..1759
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1658..1759
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1153
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1321
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1601
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1903
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1978
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2171
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..3490
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc cagcagattc acaacatcag acagcattcc tccacggggc caccacccct
     1201 cctcctggcc ccccgtgcct cagtgcccag catgcagatt cagggacaga ggatcatcca
     1261 gcagggactc atccgggtcg ccaatgtccc caacaccagt ctgctcgtca atatccctca
     1321 gcctacggca gcctcactga aggggacaac agttggctct gctcaggcaa actccactcc
     1381 cagcagtgtg gcttctgtgg ttgcctctgc tgagtcccca gctagccggc aggctgctgc
     1441 caagctagcg ctgcgcaagc agttggagaa gacactgctg gagatccccc cacccaagcc
     1501 ccctgctccg gagatgaact tcttgcccag tgctgccaac aatgaattca tctatctggt
     1561 cggcttggag gaagtggtgc agaacctgct ggagacgcaa gcgggcagga tttctgccac
     1621 ctcagctgct gccgtgttat cccgggagcc ttacatgtgt gtgcagtgta agacagactt
     1681 cacatgccgc tggcgagaga agggtggagc tgtcatgtgt gagaactgca tgacatccaa
     1741 ccaaaagaag gcactaaaag tggagcacac cagtcgcctg aaggccgcct tcgtgaaggc
     1801 gctacaacaa gagcaggaga tggagcagcg actgctgcag cagggcgtag gcaccgccag
     1861 catcaaggct gagaccgcag ctccacatcc ctcgctgaag caggtcataa agccccgacg
     1921 taagttggcg ttccgctcag gagaggcccg tgactggaat aacgggtccg tactacagac
     1981 ttccagccag ctgtcccggg gttcagccac aacacctcgt ggtgttctgc acactttcag
     2041 ccagtcaccc aaactgcaga acgcagcctc agctacggcc ctggtaagca ggactggcag
     2101 acattccgag agagtcgtgg gcaccagcaa gggcaccgcc tccaactgga aaaagacacc
     2161 tctgagcaca ggtgggacgc ttgccttcgt cagcccaagc ttggcagtgc acaagagctc
     2221 ctcggccgtg gaccgacagc gagagtacct cctggacatg attcctccac gctccatccc
     2281 ccagtcagcc acatggaaat agtgggagcc ggcccagccg aggacaggcc ctctgctctc
     2341 ccgaggccct tggtctagga cacgcagact accctcctag caagttgcct gagacagctc
     2401 aggccttggc tcttgccttg ctgtggccag gagagtacca ccatggtgcc caggatcaga
     2461 accagggacc ttccctatgg gccttctcct tcctttttgc ctttagtttg cccgacacca
     2521 gcagaaactc ggaccttggg gccagctctg cctggccagc gtgggtggga gctcaccctg
     2581 gacactgtga cacacccggg ccagactggc accgggggct cccgaagttg agccgggatt
     2641 tcgttttctt ttggcttttc ccatcttagc tccccagtct ctgcctcttc atggccatct
     2701 ataggttgaa gtttgggttt tattgggttt tttgtttttg ttttttttat aatcacctca
     2761 taatgatgat ggaattaaag tgaactgcat agacccaggg tcatggttgt gcacagtgca
     2821 gtctggcagg ctctacccca gaggatgctc agagtggcag cagcagagat ggcaggtgcc
     2881 accctggctc tggtcgtgtt tgttgctgct cactgcagtc cctggcttcc acacttagca
     2941 gaatgaaccg cagcccagat ctgtctgaca tccagaggct ccagagggat gctggggtcc
     3001 gccatgctgg agtcagagct gactgctggc tgggaggctg ctgggttact tttcgtggtt
     3061 tattttatta aaaatttcta tcctttttct cttcattttg atggacacaa tctcaagatg
     3121 cccatgcctg ccaagaggca tccaagtagg gcccagccag aacccttagg tctggagtca
     3181 gcagggctta ctccctctta gccacaggga tgtctgaaag ggctgagtct acttttgttc
     3241 tgttttgttt ccttctccct ccactcttaa caatgggttc catggtgaaa ggcagaagca
     3301 gctctgtgtc cagcacgcac ggtgcggcct tctgctcatg tgattggtcg ccgtcgtttc
     3361 cccatccagc cctggtttcc cttgacacaa tacagttagg gactttaatt taaacccttg
     3421 ttctgcagac catcgccctc tgcagacatg cccctgcctc ctcctaataa aggctcattt
     3481 aactccgtga
//
LOCUS       NM_001436784            3385 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 11, mRNA.
ACCESSION   NM_001436784 XM_063275202
VERSION     NM_001436784.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3385)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3385)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3385)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275202.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.58574.1,
                                           SRR26643297.46808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-564             JAXUCZ010000016.1  19523772-19524029
            565-697             JAXUCZ010000016.1  19543122-19543254
            698-829             JAXUCZ010000016.1  19543358-19543489
            830-919             JAXUCZ010000016.1  19543675-19543764
            920-1051            JAXUCZ010000016.1  19544907-19545038
            1052-1216           JAXUCZ010000016.1  19545145-19545309
            1217-1496           JAXUCZ010000016.1  19546706-19546985
            1497-1798           JAXUCZ010000016.1  19548553-19548854
            1799-1873           JAXUCZ010000016.1  19549511-19549585
            1874-2066           JAXUCZ010000016.1  19549883-19550075
            2067-3385           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3385
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            307..564
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2197
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 4 is encoded by transcript variant 11; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 4"
                     /protein_id="NP_001423713.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAFR
                     SGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSE
                     RVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQ
                     SATWK"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1553..1654
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1553..1654
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            565..697
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            698..829
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1051
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1216
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1496
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1798
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1873
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2066
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..3385
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcgaatg agtgaagaag catgccgaac ccgcagtcag aagcgagcct ttgaacctga
      361 cctaacggag gatgatgtgg agagcaagaa aatgaaaatg gagagaggac catcagaact
      421 gccggtggat ggagacagca gggtgatgcc agagcccagt gcaggcccag cccaggggtt
      481 gctgaggaca acagaggcca tgggcacagg atctggcgaa gggctgttag gagacgggcc
      541 tgtggacatg cgtacctcac acagtgacat gaagtctgag aagagacctc cctcgcctga
      601 tgtgattgtg ctctctgaca gcgagcagcc atcaagcccg agggtgaatg gcctgaccac
      661 agtggccttg aaagacacca gcactgaggc gctcttgaaa agcagcccag aagagcgaga
      721 acggatgatc aagcagctga aggaggaatt gaggctagag gaagcaaagc tggtcttgtt
      781 gaagaagctg cgacagagtc aaatacagaa ggaagccact gcccagaagc ctacagcttc
      841 ctcagggagc actgtgacca cccctccccc actcgtgcgg ggtccccaga acattcctgc
      901 tggcaagcca tcactccaga cctcctccac tcggataccc ggcagcatca tcccaccacc
      961 actggtccga ggtgggcagc aggtgtctgc caaactggga ccacaggcca gctctcaagt
     1021 agtcatgcca ccacttgtca ggggagccca gattcacaac atcagacagc attcctccac
     1081 ggggccacca cccctcctcc tggccccccg tgcctcagtg cccagcatgc agattcaggg
     1141 acagaggatc atccagcagg gactcatccg ggtcgccaat gtccccaaca ccagtctgct
     1201 cgtcaatatc cctcagccta cggcagcctc actgaagggg acaacagttg gctctgctca
     1261 ggcaaactcc actcccagca gtgtggcttc tgtggttgcc tctgctgagt ccccagctag
     1321 ccggcaggct gctgccaagc tagcgctgcg caagcagttg gagaagacac tgctggagat
     1381 ccccccaccc aagccccctg ctccggagat gaacttcttg cccagtgctg ccaacaatga
     1441 attcatctat ctggtcggct tggaggaagt ggtgcagaac ctgctggaga cgcaagcggg
     1501 caggatttct gccacctcag ctgctgccgt gttatcccgg gagccttaca tgtgtgtgca
     1561 gtgtaagaca gacttcacat gccgctggcg agagaagggt ggagctgtca tgtgtgagaa
     1621 ctgcatgaca tccaaccaaa agaaggcact aaaagtggag cacaccagtc gcctgaaggc
     1681 cgccttcgtg aaggcgctac aacaagagca ggagatggag cagcgactgc tgcagcaggg
     1741 cgtaggcacc gccagcatca aggctgagac cgcagctcca catccctcgc tgaagcaggt
     1801 cataaagccc cgacgtaagt tggcgttccg ctcaggagag gcccgtgact ggaataacgg
     1861 gtccgtacta cagacttcca gccagctgtc ccggggttca gccacaacac ctcgtggtgt
     1921 tctgcacact ttcagccagt cacccaaact gcagaacgca gcctcagcta cggccctggt
     1981 aagcaggact ggcagacatt ccgagagagt cgtgggcacc agcaagggca ccgcctccaa
     2041 ctggaaaaag acacctctga gcacaggtgg gacgcttgcc ttcgtcagcc caagcttggc
     2101 agtgcacaag agctcctcgg ccgtggaccg acagcgagag tacctcctgg acatgattcc
     2161 tccacgctcc atcccccagt cagccacatg gaaatagtgg gagccggccc agccgaggac
     2221 aggccctctg ctctcccgag gcccttggtc taggacacgc agactaccct cctagcaagt
     2281 tgcctgagac agctcaggcc ttggctcttg ccttgctgtg gccaggagag taccaccatg
     2341 gtgcccagga tcagaaccag ggaccttccc tatgggcctt ctccttcctt tttgccttta
     2401 gtttgcccga caccagcaga aactcggacc ttggggccag ctctgcctgg ccagcgtggg
     2461 tgggagctca ccctggacac tgtgacacac ccgggccaga ctggcaccgg gggctcccga
     2521 agttgagccg ggatttcgtt ttcttttggc ttttcccatc ttagctcccc agtctctgcc
     2581 tcttcatggc catctatagg ttgaagtttg ggttttattg ggttttttgt ttttgttttt
     2641 tttataatca cctcataatg atgatggaat taaagtgaac tgcatagacc cagggtcatg
     2701 gttgtgcaca gtgcagtctg gcaggctcta ccccagagga tgctcagagt ggcagcagca
     2761 gagatggcag gtgccaccct ggctctggtc gtgtttgttg ctgctcactg cagtccctgg
     2821 cttccacact tagcagaatg aaccgcagcc cagatctgtc tgacatccag aggctccaga
     2881 gggatgctgg ggtccgccat gctggagtca gagctgactg ctggctggga ggctgctggg
     2941 ttacttttcg tggtttattt tattaaaaat ttctatcctt tttctcttca ttttgatgga
     3001 cacaatctca agatgcccat gcctgccaag aggcatccaa gtagggccca gccagaaccc
     3061 ttaggtctgg agtcagcagg gcttactccc tcttagccac agggatgtct gaaagggctg
     3121 agtctacttt tgttctgttt tgtttccttc tccctccact cttaacaatg ggttccatgg
     3181 tgaaaggcag aagcagctct gtgtccagca cgcacggtgc ggccttctgc tcatgtgatt
     3241 ggtcgccgtc gtttccccat ccagccctgg tttcccttga cacaatacag ttagggactt
     3301 taatttaaac ccttgttctg cagaccatcg ccctctgcag acatgcccct gcctcctcct
     3361 aataaaggct catttaactc cgtga
//
LOCUS       NM_001436839            3573 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 9, mRNA.
ACCESSION   NM_001436839 XM_063287767
VERSION     NM_001436839.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287767.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29592.1,
                                           SRR26360194.275228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-660             JAXUCZ010000005.1  152866067-152866180 c
            661-849             JAXUCZ010000005.1  152864590-152864778 c
            850-969             JAXUCZ010000005.1  152864177-152864296 c
            970-1244            JAXUCZ010000005.1  152861132-152861406 c
            1245-1325           JAXUCZ010000005.1  152855768-152855848 c
            1326-1412           JAXUCZ010000005.1  152855321-152855407 c
            1413-1557           JAXUCZ010000005.1  152852539-152852683 c
            1558-1599           JAXUCZ010000005.1  152852153-152852194 c
            1600-1725           JAXUCZ010000005.1  152850411-152850536 c
            1726-2187           JAXUCZ010000005.1  152847583-152848044 c
            2188-2383           JAXUCZ010000005.1  152846792-152846987 c
            2384-2593           JAXUCZ010000005.1  152844978-152845187 c
            2594-3573           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3573
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2701
                     /gene="Srrm1"
                     /note="isoform 9 is encoded by transcript variant 9;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 9"
                     /protein_id="NP_001423768.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRTKSRSPSPAPEKKEKSPELPEPSVRMKDSSVQEATSTSDILKAP
                     KPEPVPEPKEPSPEKNSKKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRS
                     YSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSSSSSSR
                     SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSSPATPPPKTRHSPTPQQSNRAR
                     KSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQR
                     RQYRRQNQQSSSDSGSSSTSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKET
                     SPRMQMGKRWQSPVTKSRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRRSPTPPPRR
                     RTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSH
                     SPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPRPRAPQTSS
                     PPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVS
                     GSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKKK
                     KKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPRK
                     ETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    1067..>2110
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1067..>2110
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    <1802..2389
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1802..2389
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..660
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..849
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..969
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1244
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1325
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1412
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1557
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1599
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1725
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..2187
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2383
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2593
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..3573
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagaacc aagagccgga gcccttcccc tgccccagaa aagaaggaga aatctccaga
      601 gctcccagaa ccatcagtga gaatgaaaga ctcttcagta caagaggcca catctacaag
      661 tgacatcttg aaagctccca agcctgagcc tgtaccagag cccaaagaac catctccaga
      721 aaaaaattcc aaaaaggaaa aggaaaagac tcgaccaaga tctcggtcac gttccaaatc
      781 acggtcccgg actcgttctc ggtcaccttc tcatacgaga cccagacggc gacatagatc
      841 ccgatcaaga tcatactctc ctagaaggcg accaagcccc agacgacgac catctccccg
      901 aagaagaact ccaccaagac ggatgcctcc tccaccacgg cacaggagga gtaggtctcc
      961 agggagacga aggagacgtt cttccgcatc gctgtctgga agtagctcgt cgtcctcttc
     1021 atctcgttcc cggtcaccgc caaagaagcc tcccaagagg acatccagcc ctcctcggaa
     1081 aactcgtagg ttatcacctt cggcaagtcc tccgaggcga aggcaccggc cgtcatctcc
     1141 agcaactccg ccacccaaaa ctcgccattc cccaactccc cagcagtcaa accgtgcaag
     1201 aaaaagtcgt gtgtctgtgt ctccaggaag aacctcgggt aaagtgacaa aacataaagg
     1261 cactgagaaa agagagtcac cttctccagc acccaagcct agaaaagtgg agctgtctga
     1321 gtctgaggaa gacaaaggca gcaaaatggc tgcagctgat tctgtgcagc agaggcgaca
     1381 atatagacga cagaaccagc agtcttcatc tgactctggc tcctcttcca cctcagaaga
     1441 tgagcggccc aagagatccc atgtgaagaa tggtgaggta ggcaggcggc ggagacattc
     1501 tccttctcgg agtgcctctc catcacctcg aaagcgccaa aaagagactt cccctcggat
     1561 gcagatggga aagcgatggc agtcgccagt gactaaaagt agaaggagga gaagtccttc
     1621 cccacctcct gccagaagac gacgatctcc ttctccagcc cctcctcccc ctcctccccc
     1681 acctcctcgg cggcgcagat ctcccacccc accaccacga cgaaggaccc cttctcctcc
     1741 cccacgccgc cgctcaccgt ctccaagaag atactctcct cccatccaga ggagatactc
     1801 tccttcccca cctccaaaga ggagaactgc ctcgccccca cccccaccca agcgaagggc
     1861 atcgccatct cctccaccaa agcgccgggt ttcccactct ccacctccta aacaaagaag
     1921 ccccccagtc accaagagac gctcaccctc cttatcttca aagcatagga aagggtcttc
     1981 cccaggccgc tccactcggg aggcccggtc accacaacca aacaaaaggc actcgccctc
     2041 accacgacct cgggcgcctc agacctcaag ccctccccct gttcgaagag gagcttcagc
     2101 gtctccccaa ggaaggcagt ccccgtctcc gagtactagg cctattagga gagtctccag
     2161 gactccggaa cccaaaaaga taaaaaaggc tgcctcacca agccctcagt ccgtaagaag
     2221 ggtttcatct tcccgctctg tctctggatc tcctgagcca acagctaaaa agcctccagc
     2281 acccccctct cctgtgcagt ctcagtcacc ctccacaaac tggtcacctg cagcaccagc
     2341 caagaaggct aaaagcccaa caccaagccc gtcccctgcc aggaattctg atcaagaagg
     2401 aggtggaaag aagaagaaga agaagaagga caagaaacat aagaaggata agaaacacaa
     2461 gaagcacaaa aaacacaaga aggagaaggc tgtggccgta gccaccccag ctcctgctgc
     2521 ccctgcagct gtctctgctg ccgccactcc atcagcccag gaagagcctg cggcagcacc
     2581 agagcccagg aaggagactg agagtgaagc tgaagatgac aaccttgatg acttagagag
     2641 gcaccttcgg gagaaggccc ttcgatccat gcggaaggcc caagtgtccc cacagtccta
     2701 ggcggacatg tttgttacgt tgtaaatttt atttggtttg tactcaattc aatttcaaaa
     2761 ttgctaaaat gtgtttgagc tttagactat aacatttgtt gtaataattg ctaggttgaa
     2821 gttcaccatg ttaaaaaagg ggggcatgga tttacattac aaaggtgtcc acggtgtatt
     2881 agtgacaatt cttccattga catttagagt gaaatatttt aagccaaaaa aaaatctctt
     2941 ttttaaaaaa gggggtttga atattgttgg catttttgtg gttcctttaa atgccctcgc
     3001 ctctcccaaa aggttggggt cttttctttt tctccctatt ctcttgaatc ttagcaccca
     3061 tgtaaattat gcttccaacc ttgtataggt ttgtaagctt gcccagaagt gagagcactg
     3121 ttgaagtacc acagaggttt gggcgagtga gtgttgactc tgttgcccat ggagtctgct
     3181 gtcctggcag catcccagct ctagagcgcc gcactcctga gctacagggc tgccccatgg
     3241 aacagttcct aaactgacta ggaactctgg gttttctcct tccggttgtg ttgttttgtt
     3301 tccttctccc cttttcttcc tcttttgtaa aggcgattca ctagacccag gaaggaccct
     3361 tcagttacat aaatttgttt tatgaaacat ggtggctccc attcatggtt tcccttactc
     3421 ttccaattgg tacacacaac tgaggagctc ctgtatttgg ccggctggaa gggcctggac
     3481 agtgtcttga tttcacttgt tttattttat tttatttttt aactaaagct atataaagct
     3541 tgtggattaa acagaataaa tttctaaatt taa
//
LOCUS       NM_001436773            1940 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 6, mRNA.
ACCESSION   NM_001436773 XM_039109888
VERSION     NM_001436773.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039109888.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.21683.1,
                                           SRR26643298.27719.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1256           JAXUCZ010000005.1  102900532-102900653 c
            1257-1940           JAXUCZ010000005.1  102898944-102899627 c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1940
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1269
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 6 is encoded by transcript variant 6; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 6"
                     /protein_id="NP_001423702.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKQKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEHFAL"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    <607..>1254
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <607..>1254
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1256
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1940
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagcagaag
     1141 agaaagggtg gaagaaactt ccaggctgct cacaggagga acatgctaaa aggccaacat
     1201 gagaaagaag ctgcagatcg gaaacgcaag caggaggaac aaatggagac tgagcatttt
     1261 gctctgtaaa gcatttcaga tgcaacttgt gtgaaatgca ttatgcaaaa taaagtttat
     1321 tgtattgtat tcccagccaa acaacatgta atctacagta ataaaaatat atctcatttt
     1381 gggctcaaag cattaatcca gtaactgaaa agagaatacg agtggagcat acaagcgatg
     1441 aagatcttga gacagactca ttggactgaa ttttcccctc cccccttgat ggaagaaatg
     1501 ttccagattc taaattgagg acttcactat taatggcatt attaactgtg ttatgattgt
     1561 taacaaaata tcctgtaagg tacacactac atattaaggt tggccatcat tcctgttttt
     1621 ttttttagcc aagcttaaaa tgaagctttg tgtttgaagt tataacaaac atagatgaag
     1681 tcggtggttg tacattattt catttagaaa atatgaaaac tcattttgtt ttgaagatag
     1741 gtattaaact gaaatagcta ttacgttctt gaaaaatggg gcaggtgtgc ccttcccttg
     1801 acattctttt gttgttaagt tctttagagt cttgtttttt tttttctttt taatcctgag
     1861 agattaaaca gtagacttgt taagtaaaaa tatgaaactg taaccaaaat tttaaaataa
     1921 agtttttttt aaaaaaaaaa
//
LOCUS       NM_001436789            3415 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 16, mRNA.
ACCESSION   NM_001436789 XM_063275205
VERSION     NM_001436789.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3415)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275205.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1153           JAXUCZ010000016.1  19544907-19545038
            1154-1321           JAXUCZ010000016.1  19545142-19545309
            1322-1601           JAXUCZ010000016.1  19546706-19546985
            1602-1903           JAXUCZ010000016.1  19548553-19548854
            1904-2096           JAXUCZ010000016.1  19549883-19550075
            2097-3415           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3415
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2227
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 6 is encoded by transcript variant 16; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 6"
                     /protein_id="NP_001423718.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQQIHNIRQHSSTGPPPLLLAPRASVPSMQ
                     IQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASA
                     ESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQN
                     LLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALK
                     VEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQTSSQLSRGSA
                     TTPRGVLHTFSQSPKLQNAASATALVSRTGRHSERVVGTSKGTASNWKKTPLSTGGTL
                     AFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1658..1759
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1658..1759
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1153
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1321
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1601
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1903
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2096
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..3415
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc cagcagattc acaacatcag acagcattcc tccacggggc caccacccct
     1201 cctcctggcc ccccgtgcct cagtgcccag catgcagatt cagggacaga ggatcatcca
     1261 gcagggactc atccgggtcg ccaatgtccc caacaccagt ctgctcgtca atatccctca
     1321 gcctacggca gcctcactga aggggacaac agttggctct gctcaggcaa actccactcc
     1381 cagcagtgtg gcttctgtgg ttgcctctgc tgagtcccca gctagccggc aggctgctgc
     1441 caagctagcg ctgcgcaagc agttggagaa gacactgctg gagatccccc cacccaagcc
     1501 ccctgctccg gagatgaact tcttgcccag tgctgccaac aatgaattca tctatctggt
     1561 cggcttggag gaagtggtgc agaacctgct ggagacgcaa gcgggcagga tttctgccac
     1621 ctcagctgct gccgtgttat cccgggagcc ttacatgtgt gtgcagtgta agacagactt
     1681 cacatgccgc tggcgagaga agggtggagc tgtcatgtgt gagaactgca tgacatccaa
     1741 ccaaaagaag gcactaaaag tggagcacac cagtcgcctg aaggccgcct tcgtgaaggc
     1801 gctacaacaa gagcaggaga tggagcagcg actgctgcag cagggcgtag gcaccgccag
     1861 catcaaggct gagaccgcag ctccacatcc ctcgctgaag cagacttcca gccagctgtc
     1921 ccggggttca gccacaacac ctcgtggtgt tctgcacact ttcagccagt cacccaaact
     1981 gcagaacgca gcctcagcta cggccctggt aagcaggact ggcagacatt ccgagagagt
     2041 cgtgggcacc agcaagggca ccgcctccaa ctggaaaaag acacctctga gcacaggtgg
     2101 gacgcttgcc ttcgtcagcc caagcttggc agtgcacaag agctcctcgg ccgtggaccg
     2161 acagcgagag tacctcctgg acatgattcc tccacgctcc atcccccagt cagccacatg
     2221 gaaatagtgg gagccggccc agccgaggac aggccctctg ctctcccgag gcccttggtc
     2281 taggacacgc agactaccct cctagcaagt tgcctgagac agctcaggcc ttggctcttg
     2341 ccttgctgtg gccaggagag taccaccatg gtgcccagga tcagaaccag ggaccttccc
     2401 tatgggcctt ctccttcctt tttgccttta gtttgcccga caccagcaga aactcggacc
     2461 ttggggccag ctctgcctgg ccagcgtggg tgggagctca ccctggacac tgtgacacac
     2521 ccgggccaga ctggcaccgg gggctcccga agttgagccg ggatttcgtt ttcttttggc
     2581 ttttcccatc ttagctcccc agtctctgcc tcttcatggc catctatagg ttgaagtttg
     2641 ggttttattg ggttttttgt ttttgttttt tttataatca cctcataatg atgatggaat
     2701 taaagtgaac tgcatagacc cagggtcatg gttgtgcaca gtgcagtctg gcaggctcta
     2761 ccccagagga tgctcagagt ggcagcagca gagatggcag gtgccaccct ggctctggtc
     2821 gtgtttgttg ctgctcactg cagtccctgg cttccacact tagcagaatg aaccgcagcc
     2881 cagatctgtc tgacatccag aggctccaga gggatgctgg ggtccgccat gctggagtca
     2941 gagctgactg ctggctggga ggctgctggg ttacttttcg tggtttattt tattaaaaat
     3001 ttctatcctt tttctcttca ttttgatgga cacaatctca agatgcccat gcctgccaag
     3061 aggcatccaa gtagggccca gccagaaccc ttaggtctgg agtcagcagg gcttactccc
     3121 tcttagccac agggatgtct gaaagggctg agtctacttt tgttctgttt tgtttccttc
     3181 tccctccact cttaacaatg ggttccatgg tgaaaggcag aagcagctct gtgtccagca
     3241 cgcacggtgc ggccttctgc tcatgtgatt ggtcgccgtc gtttccccat ccagccctgg
     3301 tttcccttga cacaatacag ttagggactt taatttaaac ccttgttctg cagaccatcg
     3361 ccctctgcag acatgcccct gcctcctcct aataaaggct catttaactc cgtga
//
LOCUS       NM_001436778            3394 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 4, mRNA.
ACCESSION   NM_001436778 XM_063275197
VERSION     NM_001436778.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3394)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3394)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3394)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275197.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.53660.1,
                                           SRR26643284.18527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-564             JAXUCZ010000016.1  19523772-19524029
            565-697             JAXUCZ010000016.1  19543122-19543254
            698-829             JAXUCZ010000016.1  19543358-19543489
            830-919             JAXUCZ010000016.1  19543675-19543764
            920-1060            JAXUCZ010000016.1  19544907-19545047
            1061-1225           JAXUCZ010000016.1  19545145-19545309
            1226-1505           JAXUCZ010000016.1  19546706-19546985
            1506-1807           JAXUCZ010000016.1  19548553-19548854
            1808-1882           JAXUCZ010000016.1  19549511-19549585
            1883-2075           JAXUCZ010000016.1  19549883-19550075
            2076-3394           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3394
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            307..564
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2206
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 2 is encoded by transcript variant 4; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 2"
                     /protein_id="NP_001423707.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKL
                     AFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGR
                     HSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRS
                     IPQSATWK"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1562..1663
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1562..1663
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            565..697
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            698..829
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1060
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1225
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1505
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1807
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1882
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2075
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..3394
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcgaatg agtgaagaag catgccgaac ccgcagtcag aagcgagcct ttgaacctga
      361 cctaacggag gatgatgtgg agagcaagaa aatgaaaatg gagagaggac catcagaact
      421 gccggtggat ggagacagca gggtgatgcc agagcccagt gcaggcccag cccaggggtt
      481 gctgaggaca acagaggcca tgggcacagg atctggcgaa gggctgttag gagacgggcc
      541 tgtggacatg cgtacctcac acagtgacat gaagtctgag aagagacctc cctcgcctga
      601 tgtgattgtg ctctctgaca gcgagcagcc atcaagcccg agggtgaatg gcctgaccac
      661 agtggccttg aaagacacca gcactgaggc gctcttgaaa agcagcccag aagagcgaga
      721 acggatgatc aagcagctga aggaggaatt gaggctagag gaagcaaagc tggtcttgtt
      781 gaagaagctg cgacagagtc aaatacagaa ggaagccact gcccagaagc ctacagcttc
      841 ctcagggagc actgtgacca cccctccccc actcgtgcgg ggtccccaga acattcctgc
      901 tggcaagcca tcactccaga cctcctccac tcggataccc ggcagcatca tcccaccacc
      961 actggtccga ggtgggcagc aggtgtctgc caaactggga ccacaggcca gctctcaagt
     1021 agtcatgcca ccacttgtca ggggagccca ggtgagtcag attcacaaca tcagacagca
     1081 ttcctccacg gggccaccac ccctcctcct ggccccccgt gcctcagtgc ccagcatgca
     1141 gattcaggga cagaggatca tccagcaggg actcatccgg gtcgccaatg tccccaacac
     1201 cagtctgctc gtcaatatcc ctcagcctac ggcagcctca ctgaagggga caacagttgg
     1261 ctctgctcag gcaaactcca ctcccagcag tgtggcttct gtggttgcct ctgctgagtc
     1321 cccagctagc cggcaggctg ctgccaagct agcgctgcgc aagcagttgg agaagacact
     1381 gctggagatc cccccaccca agccccctgc tccggagatg aacttcttgc ccagtgctgc
     1441 caacaatgaa ttcatctatc tggtcggctt ggaggaagtg gtgcagaacc tgctggagac
     1501 gcaagcgggc aggatttctg ccacctcagc tgctgccgtg ttatcccggg agccttacat
     1561 gtgtgtgcag tgtaagacag acttcacatg ccgctggcga gagaagggtg gagctgtcat
     1621 gtgtgagaac tgcatgacat ccaaccaaaa gaaggcacta aaagtggagc acaccagtcg
     1681 cctgaaggcc gccttcgtga aggcgctaca acaagagcag gagatggagc agcgactgct
     1741 gcagcagggc gtaggcaccg ccagcatcaa ggctgagacc gcagctccac atccctcgct
     1801 gaagcaggtc ataaagcccc gacgtaagtt ggcgttccgc tcaggagagg cccgtgactg
     1861 gaataacggg tccgtactac agacttccag ccagctgtcc cggggttcag ccacaacacc
     1921 tcgtggtgtt ctgcacactt tcagccagtc acccaaactg cagaacgcag cctcagctac
     1981 ggccctggta agcaggactg gcagacattc cgagagagtc gtgggcacca gcaagggcac
     2041 cgcctccaac tggaaaaaga cacctctgag cacaggtggg acgcttgcct tcgtcagccc
     2101 aagcttggca gtgcacaaga gctcctcggc cgtggaccga cagcgagagt acctcctgga
     2161 catgattcct ccacgctcca tcccccagtc agccacatgg aaatagtggg agccggccca
     2221 gccgaggaca ggccctctgc tctcccgagg cccttggtct aggacacgca gactaccctc
     2281 ctagcaagtt gcctgagaca gctcaggcct tggctcttgc cttgctgtgg ccaggagagt
     2341 accaccatgg tgcccaggat cagaaccagg gaccttccct atgggccttc tccttccttt
     2401 ttgcctttag tttgcccgac accagcagaa actcggacct tggggccagc tctgcctggc
     2461 cagcgtgggt gggagctcac cctggacact gtgacacacc cgggccagac tggcaccggg
     2521 ggctcccgaa gttgagccgg gatttcgttt tcttttggct tttcccatct tagctcccca
     2581 gtctctgcct cttcatggcc atctataggt tgaagtttgg gttttattgg gttttttgtt
     2641 tttgtttttt ttataatcac ctcataatga tgatggaatt aaagtgaact gcatagaccc
     2701 agggtcatgg ttgtgcacag tgcagtctgg caggctctac cccagaggat gctcagagtg
     2761 gcagcagcag agatggcagg tgccaccctg gctctggtcg tgtttgttgc tgctcactgc
     2821 agtccctggc ttccacactt agcagaatga accgcagccc agatctgtct gacatccaga
     2881 ggctccagag ggatgctggg gtccgccatg ctggagtcag agctgactgc tggctgggag
     2941 gctgctgggt tacttttcgt ggtttatttt attaaaaatt tctatccttt ttctcttcat
     3001 tttgatggac acaatctcaa gatgcccatg cctgccaaga ggcatccaag tagggcccag
     3061 ccagaaccct taggtctgga gtcagcaggg cttactccct cttagccaca gggatgtctg
     3121 aaagggctga gtctactttt gttctgtttt gtttccttct ccctccactc ttaacaatgg
     3181 gttccatggt gaaaggcaga agcagctctg tgtccagcac gcacggtgcg gccttctgct
     3241 catgtgattg gtcgccgtcg tttccccatc cagccctggt ttcccttgac acaatacagt
     3301 tagggacttt aatttaaacc cttgttctgc agaccatcgc cctctgcaga catgcccctg
     3361 cctcctccta ataaaggctc atttaactcc gtga
//
LOCUS       NM_001436766            2101 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus DEAD-box helicase 49 (Ddx49), transcript variant
            2, mRNA.
ACCESSION   NM_001436766
VERSION     NM_001436766.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Awasthi,S., Verma,M., Mahesh,A., K Khan,M.I., Govindaraju,G.,
            Rajavelu,A., Chavali,P.L., Chavali,S. and Dhayalan,A.
  TITLE     DDX49 is an RNA helicase that affects translation by regulating
            mRNA export and the levels of pre-ribosomal RNA
  JOURNAL   Nucleic Acids Res 46 (12), 6304-6317 (2018)
   PUBMED   29618122
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1234396.1,
                                           SRR26360176.227984.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000016.1  19159349-19159493
            146-269             JAXUCZ010000016.1  19160495-19160618
            270-355             JAXUCZ010000016.1  19162513-19162598
            356-477             JAXUCZ010000016.1  19162681-19162802
            478-665             JAXUCZ010000016.1  19163352-19163539
            666-806             JAXUCZ010000016.1  19163622-19163762
            807-882             JAXUCZ010000016.1  19164230-19164305
            883-959             JAXUCZ010000016.1  19165054-19165130
            960-1057            JAXUCZ010000016.1  19165222-19165319
            1058-1132           JAXUCZ010000016.1  19165844-19165918
            1133-1200           JAXUCZ010000016.1  19166381-19166448
            1201-1272           JAXUCZ010000016.1  19166550-19166621
            1273-2101           JAXUCZ010000016.1  19166753-19167581
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2101
                     /gene="Ddx49"
                     /note="DEAD-box helicase 49"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
     exon            1..145
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Ddx49"
                     /note="upstream in-frame stop codon"
     CDS             31..1452
                     /gene="Ddx49"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable ATP-dependent RNA helicase DDX49; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 49"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX49
                     isoform 2"
                     /protein_id="NP_001423695.1"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
                     /translation="MAGFAELRLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLG
                     CAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC
                     IIVGGMDMVTQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIRFLVLDEADRLLEQ
                     GCTDFTADLETILSAVPARRQTLLFSATLTDTLKELQGLATNQPFFWEAQATVRTVEQ
                     LDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTV
                     ALHSMMKQKERFAALARFKSSTYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIH
                     RVGRTARAGRQGQAITLVTQYDIHLLHAIEEEIKQQLAELAVEEAQVLQILTQVNVKL
                     EASHFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKVEQTLRQQKAG
                     STGRRSRPPRPRPQEPARAEAQN"
     misc_feature    31..1332
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     misc_feature    31..1332
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     exon            146..269
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            270..355
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            356..477
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            478..665
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            666..806
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            807..882
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            883..959
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1057
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1132
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1200
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1272
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..2101
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accactaggt tctctacact agtctgaagc atggcggggt tcgctgagct ccggctatcg
       61 tcgtggctgg tggaacagtg tcgacagctg gggttgaagc agcccacgcc ggtgcagctc
      121 gggtgcatcc cggccatcct ggaaggtcgg gactgcttgg gttgtgcaaa aacaggaagt
      181 ggcaagacag cagcctttgt acttcccatc ctgcagaagc tgtctgagga cccttatggc
      241 atcttctgcc tggttttgac acccactaga gagctggcct accagatagc tgagcagttc
      301 cgagtgctgg ggaagcctct gggcctaaag gactgcatca tcgttggtgg catggacatg
      361 gtgactcagg ccctggagct ctctcggaag ccacacgtgg ttattgccac ccctgggcgc
      421 ctggctgacc acctgcgcag ttccaacact ttcaacatga agaaaatcag attcttggtg
      481 ttggacgagg ccgataggct gctggagcag ggttgcaccg acttcactgc agacctggag
      541 accatcctgt cagctgttcc agcacgcagg caaaccctcc tgttcagtgc cacactgaca
      601 gacacactca aggagctgca gggcctggct accaaccagc ccttcttttg ggaggcacag
      661 gccacggttc gcacggtgga gcagcttgac cagcgctatc tgctggtgcc tgagaaggtg
      721 aaggacgcct acctggttca cctggtccag accttccagg accagctgga ggactgctcc
      781 atcatcatct tcaccaatac ctgcaagacc tgccagatcc tttgtatgat gcttcgaaag
      841 ttcaacttcc ccacagtggc actgcactcc atgatgaagc agaaagagcg ctttgcagcc
      901 ctggccagat tcaagtccag cacctatcgg attcttattg ctactgacgt ggcctccaga
      961 ggcctggaca tccccactgt gcaggtggtc atcaaccaca acacccctgg gctccccaag
     1021 atctacatcc atagggtcgg tcgcacagcc cgtgcaggga ggcagggaca ggccatcaca
     1081 ctggtgacgc agtacgacat ccacctgttg catgccatcg aggaggagat caaacagcag
     1141 ctggctgaat tggcagtgga ggaggcccag gtcctgcaga tcctcacaca ggtcaacgtg
     1201 aaactggagg cttcgcattt tgatgaaaag aaggagatca acaagcggaa acagatgatc
     1261 ctggagggga aggacccgga cctggaggcc aagcgcaaag ctgagctggc caagattaag
     1321 caacagaacc ggcgcttcaa ggagaaagtg gagcagacgc ttcggcagca gaaagcaggg
     1381 agcacaggcc ggcggtcgcg tcctcccaga cctcgtcccc aagagccagc cagggctgag
     1441 gctcagaact gagctgtaaa cctactgcag gtggcccctg acttcagtaa atgctctttg
     1501 aacctgtcag tcagacttga aaatggggca ggatgagtgt agagccttcc ggtcacagga
     1561 ccccaatgcc tctgttgccc catgaggata accggtgcag ccttccctca cagtgtccct
     1621 ggggtgcaag gcagcagcag ccaaggacag caggtgtcaa caacgccaca cgtagaaatg
     1681 ttacctgggc agaagcactg cccaaggatt ctagaaaatt ctacacggtg caaagctcag
     1741 agacagctgg ggccccctgg tccctgccag ggtgccttgg ggccgcaggc ctccagagca
     1801 aactagggtg ctgcctctgc caggcgagcc aggccctcgc gcagctcgct cagctcgaac
     1861 agccgcacgt ccaacagctg cgcagcccgg cccacctctg ctcgtgcgcg ctcccgctcg
     1921 gcccgcgcct cctccaggtt gctttccatc gcccgcagct gctgctccag ttctgcattc
     1981 cgggtctcca ggtcctgcag cgggaggcaa ggggtgggac aacctgtgaa gctttggttg
     2041 ccagtcctct ctgatgcggt ctgtgtcttc acggggtcag taaaggacca cggaagtatg
     2101 a
//
LOCUS       NM_001013136            1200 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus regulatory factor X-associated ankyrin-containing
            protein (Rfxank), transcript variant 3, mRNA.
ACCESSION   NM_001013136 XM_224739
VERSION     NM_001013136.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Wiszniewski,W., Fondaneche,M.C., Louise-Plence,P.,
            Prochnicka-Chalufour,A., Selz,F., Picard,C., Le Deist,F.,
            Eliaou,J.F., Fischer,A. and Lisowska-Grospierre,B.
  TITLE     Novel mutations in the RFXANK gene: RFX complex containing
            in-vitro-generated RFXANK mutant binds the promoter without
            transactivating MHC II
  JOURNAL   Immunogenetics 54 (11), 747-755 (2003)
   PUBMED   12618906
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Lin,J.H., Makris,A., McMahon,C., Bear,S.E., Patriotis,C.,
            Prasad,V.R., Brent,R., Golemis,E.A. and Tsichlis,P.N.
  TITLE     The ankyrin repeat-containing adaptor protein Tvl-1 is a novel
            substrate and regulator of Raf-1
  JOURNAL   J Biol Chem 274 (21), 14706-14715 (1999)
   PUBMED   10329666
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Masternak,K., Barras,E., Zufferey,M., Conrad,B., Corthals,G.,
            Aebersold,R., Sanchez,J.C., Hochstrasser,D.F., Mach,B. and Reith,W.
  TITLE     A gene encoding a novel RFX-associated transactivator is mutated in
            the majority of MHC class II deficiency patients
  JOURNAL   Nat Genet 20 (3), 273-277 (1998)
   PUBMED   9806546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001013136.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087111.1, SRR26360194.2550749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000016.1  19315505-19315709
            206-400             JAXUCZ010000016.1  19316487-19316681
            401-556             JAXUCZ010000016.1  19319861-19320016
            557-622             JAXUCZ010000016.1  19320608-19320673
            623-723             JAXUCZ010000016.1  19320847-19320947
            724-849             JAXUCZ010000016.1  19321077-19321202
            850-916             JAXUCZ010000016.1  19321578-19321644
            917-997             JAXUCZ010000016.1  19321972-19322052
            998-1200            JAXUCZ010000016.1  19322625-19322827
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1200
                     /gene="Rfxank"
                     /note="regulatory factor X-associated ankyrin-containing
                     protein"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
     exon            1..205
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    136..138
                     /gene="Rfxank"
                     /note="upstream in-frame stop codon"
     exon            206..400
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1068
                     /gene="Rfxank"
                     /note="isoform 2 is encoded by transcript variant 3;
                     DNA-binding protein RFXANK"
                     /codon_start=1
                     /product="DNA-binding protein RFXANK isoform 2"
                     /protein_id="NP_001013154.1"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
                     /translation="MEPTQVAENLIPNQQSLAPDLEDPEDRRDESPDSSDTVVLSLFP
                     CTPDAVNPEADASASSLQVPAASVWTPLAQAQTPGEQALPLLAGSFLKHSTTLTNRQR
                     GNEVSALPATLDSLSIHQLAAQGELSQLKDHLRKGDNLVNKPDERGFTPLIWASAFGE
                     IETVRFLLDWGADPHILAKERESALSLASMGGYTDIVRLLLDRDVDINIYDWNGGTPL
                     LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVMESHILKLFQG
                     TLGPADPE"
     misc_feature    427..1032
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    427..1032
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    565..648
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    565..648
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(652..654,658..660,670..675,682..690,694..699,
                     709..711,718..720,745..747,751..753,757..759,769..774,
                     781..789,793..798,808..810,817..819,844..846,850..852,
                     856..858,868..873,880..888,892..897,907..909,916..918)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(652..654,658..660,670..675,682..690,694..699,
                     709..711,718..720,745..747,751..753,757..759,769..774,
                     781..789,793..798,808..810,817..819,844..846,850..852,
                     856..858,868..873,880..888,892..897,907..909,916..918)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    652..747
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    652..747
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    751..846
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    751..846
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    850..936
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    850..936
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            401..556
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            557..622
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            623..723
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            724..849
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            850..916
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            917..997
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1200
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggaggag ttctcctgta ggaatagtcc tggcgtatta agttgctgct ctatgtccca
       61 gcagaagaag ctagaggact gggcgtccgg tcaccaactt gctcctcacg agatctactg
      121 gactagaaaa gtttgtgaac agagcttccc gagttttggg agagccaggc tggcagcgta
      181 agggaacgga ggaggctgga gggagcttcc tcgatggagc ccactcaggt tgcagagaac
      241 ctcatcccaa accagcagtc ccttgctcct gacctagagg atcctgagga ccgcagagat
      301 gaatccccag atagctctga cactgtcgtc ctcagtctgt tcccctgcac cccagacgct
      361 gtgaatcctg aggcagatgc cagtgcatcc tcactacagg ttcctgcagc atctgtctgg
      421 acacccttgg cacaagccca aacaccaggg gaacaagccc ttcctctcct cgcaggaagt
      481 ttcttgaagc actccacaac cctcacaaac cggcaacgtg ggaatgaggt ctcagctctg
      541 ccagccaccc tggactccct gtctatccac cagcttgcag cccaggggga gctgagtcaa
      601 ctgaaggatc acctgcgaaa gggtgacaac ctggtcaaca agccggatga acgtggcttc
      661 acccccctca tctgggcctc agcctttgga gaaattgaga cagtacgctt cctgctagac
      721 tggggtgctg acccccacat cctggccaag gagcgggaaa gcgctctgtc gcttgccagt
      781 atgggtggtt acacggacat cgtgaggttg ctgcttgacc gtgatgtgga catcaacatc
      841 tatgactgga atggggggac accactgctc tacgctgtgc gtgggaacca tgtgaagtgt
      901 gtggaggcct tactcgcccg aggtgctgac ctcaccacag aggccgactc tggctacacc
      961 ccaatggacc tcgccgtggc cctaggatac cgcaaagtgc aacaggtgat ggagagccac
     1021 atcctcaaac tgttccaggg taccctgggg cctgcggacc cggagtgaag acagcctgtt
     1081 gggaacccag gcactcaggg acaaaccagt cagcccacaa ctggcttgga aggcagctcc
     1141 tggacagtgg tgggaagagc cctccccaac aggaaccaat aaatctgtgc agaacttgaa
//
LOCUS       NM_001436767            2092 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus DEAD-box helicase 49 (Ddx49), transcript variant
            3, mRNA.
ACCESSION   NM_001436767
VERSION     NM_001436767.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Awasthi,S., Verma,M., Mahesh,A., K Khan,M.I., Govindaraju,G.,
            Rajavelu,A., Chavali,P.L., Chavali,S. and Dhayalan,A.
  TITLE     DDX49 is an RNA helicase that affects translation by regulating
            mRNA export and the levels of pre-ribosomal RNA
  JOURNAL   Nucleic Acids Res 46 (12), 6304-6317 (2018)
   PUBMED   29618122
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1351704.1,
                                           SRR21887623.2151621.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000016.1  19159349-19159493
            146-269             JAXUCZ010000016.1  19160495-19160618
            270-355             JAXUCZ010000016.1  19162513-19162598
            356-477             JAXUCZ010000016.1  19162681-19162802
            478-665             JAXUCZ010000016.1  19163352-19163539
            666-806             JAXUCZ010000016.1  19163622-19163762
            807-882             JAXUCZ010000016.1  19164230-19164305
            883-959             JAXUCZ010000016.1  19165054-19165130
            960-1057            JAXUCZ010000016.1  19165222-19165319
            1058-1132           JAXUCZ010000016.1  19165844-19165918
            1133-1191           JAXUCZ010000016.1  19166381-19166439
            1192-1263           JAXUCZ010000016.1  19166550-19166621
            1264-2092           JAXUCZ010000016.1  19166753-19167581
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2092
                     /gene="Ddx49"
                     /note="DEAD-box helicase 49"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
     exon            1..145
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Ddx49"
                     /note="upstream in-frame stop codon"
     CDS             31..1443
                     /gene="Ddx49"
                     /EC_number="3.6.4.13"
                     /note="isoform 3 is encoded by transcript variant 3;
                     probable ATP-dependent RNA helicase DDX49; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 49"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX49
                     isoform 3"
                     /protein_id="NP_001423696.1"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
                     /translation="MAGFAELRLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLG
                     CAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC
                     IIVGGMDMVTQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIRFLVLDEADRLLEQ
                     GCTDFTADLETILSAVPARRQTLLFSATLTDTLKELQGLATNQPFFWEAQATVRTVEQ
                     LDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTV
                     ALHSMMKQKERFAALARFKSSTYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIH
                     RVGRTARAGRQGQAITLVTQYDIHLLHAIEEEIKQQLAELAVEEAQVLQILTQKLEAS
                     HFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKVEQTLRQQKAGSTG
                     RRSRPPRPRPQEPARAEAQN"
     misc_feature    31..1323
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     misc_feature    31..1323
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     exon            146..269
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            270..355
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            356..477
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            478..665
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            666..806
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            807..882
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            883..959
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1057
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1132
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1191
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1263
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..2092
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accactaggt tctctacact agtctgaagc atggcggggt tcgctgagct ccggctatcg
       61 tcgtggctgg tggaacagtg tcgacagctg gggttgaagc agcccacgcc ggtgcagctc
      121 gggtgcatcc cggccatcct ggaaggtcgg gactgcttgg gttgtgcaaa aacaggaagt
      181 ggcaagacag cagcctttgt acttcccatc ctgcagaagc tgtctgagga cccttatggc
      241 atcttctgcc tggttttgac acccactaga gagctggcct accagatagc tgagcagttc
      301 cgagtgctgg ggaagcctct gggcctaaag gactgcatca tcgttggtgg catggacatg
      361 gtgactcagg ccctggagct ctctcggaag ccacacgtgg ttattgccac ccctgggcgc
      421 ctggctgacc acctgcgcag ttccaacact ttcaacatga agaaaatcag attcttggtg
      481 ttggacgagg ccgataggct gctggagcag ggttgcaccg acttcactgc agacctggag
      541 accatcctgt cagctgttcc agcacgcagg caaaccctcc tgttcagtgc cacactgaca
      601 gacacactca aggagctgca gggcctggct accaaccagc ccttcttttg ggaggcacag
      661 gccacggttc gcacggtgga gcagcttgac cagcgctatc tgctggtgcc tgagaaggtg
      721 aaggacgcct acctggttca cctggtccag accttccagg accagctgga ggactgctcc
      781 atcatcatct tcaccaatac ctgcaagacc tgccagatcc tttgtatgat gcttcgaaag
      841 ttcaacttcc ccacagtggc actgcactcc atgatgaagc agaaagagcg ctttgcagcc
      901 ctggccagat tcaagtccag cacctatcgg attcttattg ctactgacgt ggcctccaga
      961 ggcctggaca tccccactgt gcaggtggtc atcaaccaca acacccctgg gctccccaag
     1021 atctacatcc atagggtcgg tcgcacagcc cgtgcaggga ggcagggaca ggccatcaca
     1081 ctggtgacgc agtacgacat ccacctgttg catgccatcg aggaggagat caaacagcag
     1141 ctggctgaat tggcagtgga ggaggcccag gtcctgcaga tcctcacaca gaaactggag
     1201 gcttcgcatt ttgatgaaaa gaaggagatc aacaagcgga aacagatgat cctggagggg
     1261 aaggacccgg acctggaggc caagcgcaaa gctgagctgg ccaagattaa gcaacagaac
     1321 cggcgcttca aggagaaagt ggagcagacg cttcggcagc agaaagcagg gagcacaggc
     1381 cggcggtcgc gtcctcccag acctcgtccc caagagccag ccagggctga ggctcagaac
     1441 tgagctgtaa acctactgca ggtggcccct gacttcagta aatgctcttt gaacctgtca
     1501 gtcagacttg aaaatggggc aggatgagtg tagagccttc cggtcacagg accccaatgc
     1561 ctctgttgcc ccatgaggat aaccggtgca gccttccctc acagtgtccc tggggtgcaa
     1621 ggcagcagca gccaaggaca gcaggtgtca acaacgccac acgtagaaat gttacctggg
     1681 cagaagcact gcccaaggat tctagaaaat tctacacggt gcaaagctca gagacagctg
     1741 gggccccctg gtccctgcca gggtgccttg gggccgcagg cctccagagc aaactagggt
     1801 gctgcctctg ccaggcgagc caggccctcg cgcagctcgc tcagctcgaa cagccgcacg
     1861 tccaacagct gcgcagcccg gcccacctct gctcgtgcgc gctcccgctc ggcccgcgcc
     1921 tcctccaggt tgctttccat cgcccgcagc tgctgctcca gttctgcatt ccgggtctcc
     1981 aggtcctgca gcgggaggca aggggtggga caacctgtga agctttggtt gccagtcctc
     2041 tctgatgcgg tctgtgtctt cacggggtca gtaaaggacc acggaagtat ga
//
LOCUS       NM_001436809            2063 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 4, mRNA.
ACCESSION   NM_001436809 XM_008771264
VERSION     NM_001436809.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_008771264.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2795976.1,
                                           SRR26360181.138198.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000016.1  52867643-52867789   c
            148-1244            JAXUCZ010000016.1  52848306-52849402   c
            1245-1513           JAXUCZ010000016.1  52836572-52836840   c
            1514-1664           JAXUCZ010000016.1  52822585-52822735   c
            1665-1771           JAXUCZ010000016.1  52821565-52821671   c
            1772-2063           JAXUCZ010000016.1  52818692-52818983   c
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2063
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..147
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            148..1244
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1810
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 2"
                     /protein_id="NP_001423738.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQNDDDFKEG
                     INKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKPKFPSKE
                     QHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYYTDGEES
                     SDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIGSDMQNK
                     PDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPASTPDSSP
                     AQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQNFAPKSS
                     VLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNYSFTREE
                     VRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQRIERENM
                     ALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRGASRTSS
                     ATSGLSCKTDRSVLDTSSGFLLRPKPPNIQCSNSKVLRSH"
     misc_feature    185..187
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    218..220
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    416..1054
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    626..628
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    641..643
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    644..646
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    866..868
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    938..940
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    1226..1534
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1226..1534
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1382..1456
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1652..1807
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1245..1513
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1664
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1771
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2063
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccggta ctcacccgca gcggacagcg gacggccgcc gccagccggc tccaggaaga
       61 ggcgaagtcc ggcggctggg cgcgcgggct ccagcagacg agcgcgacca gtgtccccag
      121 cagcaaggcg gccgcggcgc agctcagata tacttttggc atcatggatc ggtttggcga
      181 tatctcagaa ggtgaagtgg accattcttt ctttgacagt gattttgaag acacaaagaa
      241 atgtgaaagt aattccattt ttgacaagca aaatgatgat gactttaagg aaggaataaa
      301 taaggacatc aaaaatttaa acttgaaatt tggagtacaa aatgataacc ttaaagagaa
      361 aatagataat gacacagaaa atgtgaacgt gaaacttggg atacaaacaa aggaaaatta
      421 ccttactcag aagggaaatg aaaggaaacc aaaatttccc tcaaaggaac aacatgtaga
      481 aaatgaccct atacaaacaa gaagtccctc attgttgact tcttcaaggt caaaaaaact
      541 gtgtgatacc acaaaaggaa ataaactaca tttgcctgtt ccaaatagaa ttcctaaaat
      601 tgtgaaaggt gaggatgact actacacaga tggagaggaa agcagtgacg atgggaagaa
      661 gtaccacgtg aggtctaagt cagcgaagcc ctctagtaac ttaaaaaaga acaacacaag
      721 taagaagtat tccaaagcca gttcctcctc tctgtcttcc tcatcttcac gatcaagctc
      781 agactgctca gatataggat ctgacatgca aaataaacct gattcaggtt catcagggaa
      841 acgagtttct agtgtaaccc cctcatcacc aaagcagaag tgtaagtcag gaagaaaatc
      901 aagtgctaaa cagaaggcag gtgactataa tgcagagtca gaagacaacg taacagacgt
      961 aactcccgcg tcaactccag acagcagccc tgcccagcca tttgagttga gccaatcaca
     1021 gaatcaaaaa gtaaaagtta aaagacaaga aaatgtgagc cgggatgtgt atgaggatgt
     1081 ggaggcttta aagaatgatt caagatgtct gaaatcagcc aaaaggaaag aaaagcatgg
     1141 acagaatttt gctccaaaat catcagtgtt agatgcaaat ctagaccgta gatccaagca
     1201 aaaagtctta catgacacaa tggaccttaa tcatctgttg aaagctttcc tgcagttaga
     1261 taaaaaggga ccacagaaac atcactttga gcagccttca ataataccta ggaaaaacta
     1321 ctctttcaca agagaagagg tgagacagat tgatcgggag aatcagaggc ttttgaaaga
     1381 actgtcaaga caggctgaaa aaccaggaaa caaaagtaca attcctggaa gatcgctcgg
     1441 ccatccacct aagttgtatc acagtgctct caacagacag agggaacagc aaaggattga
     1501 aagagaaaat atggctttat tgaaacggct tgaagctgtg aagccaacag ttggcatgaa
     1561 acgctctgaa cagctgatgg actaccatcg gaatatcagt tacctcaacc cttcaccgtc
     1621 cgtcagacga gtgagatcta ctcttggcca ttacagccca ctgagaggag cttccaggac
     1681 atccagtgca accagtggtc tcagttgtaa gactgatcga tcagtgttgg acacatccag
     1741 tggctttttg ctaagaccga aacccccgaa tatacaatgc agcaactcca aagtattaag
     1801 atcacactaa gctgaagatg cacctttgcc ctggttagca acgcaaaacc gtatcgtcat
     1861 acatgccaag gccttagcgt gtagatgtct gtacaccggc acagcgaatg agctcactgc
     1921 taatggctga gttgcttatt ttcatgaaca aagattagca agaaactgtt aaaccatctt
     1981 tttaaaaact gttctagttt gtcatatttt aggcatgaag aactagcttg gcttactgaa
     2041 gaaataaaag atttaaagag aac
//
LOCUS       NM_001436781            3388 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 8, mRNA.
ACCESSION   NM_001436781 XM_063275199
VERSION     NM_001436781.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3388)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3388)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3388)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.52413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-564             JAXUCZ010000016.1  19523772-19524029
            565-697             JAXUCZ010000016.1  19543122-19543254
            698-829             JAXUCZ010000016.1  19543358-19543489
            830-919             JAXUCZ010000016.1  19543675-19543764
            920-1051            JAXUCZ010000016.1  19544907-19545038
            1052-1219           JAXUCZ010000016.1  19545142-19545309
            1220-1499           JAXUCZ010000016.1  19546706-19546985
            1500-1801           JAXUCZ010000016.1  19548553-19548854
            1802-1876           JAXUCZ010000016.1  19549511-19549585
            1877-2069           JAXUCZ010000016.1  19549883-19550075
            2070-3388           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3388
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            307..564
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2200
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 3 is encoded by transcript variant 8; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 3"
                     /protein_id="NP_001423710.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQQIHNIRQHSSTGPPPLLLAPRASVPSMQ
                     IQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASA
                     ESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQN
                     LLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALK
                     VEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAF
                     RSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHS
                     ERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIP
                     QSATWK"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1556..1657
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1556..1657
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            565..697
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            698..829
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1051
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1219
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1499
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1801
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1876
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2069
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3388
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcgaatg agtgaagaag catgccgaac ccgcagtcag aagcgagcct ttgaacctga
      361 cctaacggag gatgatgtgg agagcaagaa aatgaaaatg gagagaggac catcagaact
      421 gccggtggat ggagacagca gggtgatgcc agagcccagt gcaggcccag cccaggggtt
      481 gctgaggaca acagaggcca tgggcacagg atctggcgaa gggctgttag gagacgggcc
      541 tgtggacatg cgtacctcac acagtgacat gaagtctgag aagagacctc cctcgcctga
      601 tgtgattgtg ctctctgaca gcgagcagcc atcaagcccg agggtgaatg gcctgaccac
      661 agtggccttg aaagacacca gcactgaggc gctcttgaaa agcagcccag aagagcgaga
      721 acggatgatc aagcagctga aggaggaatt gaggctagag gaagcaaagc tggtcttgtt
      781 gaagaagctg cgacagagtc aaatacagaa ggaagccact gcccagaagc ctacagcttc
      841 ctcagggagc actgtgacca cccctccccc actcgtgcgg ggtccccaga acattcctgc
      901 tggcaagcca tcactccaga cctcctccac tcggataccc ggcagcatca tcccaccacc
      961 actggtccga ggtgggcagc aggtgtctgc caaactggga ccacaggcca gctctcaagt
     1021 agtcatgcca ccacttgtca ggggagccca gcagattcac aacatcagac agcattcctc
     1081 cacggggcca ccacccctcc tcctggcccc ccgtgcctca gtgcccagca tgcagattca
     1141 gggacagagg atcatccagc agggactcat ccgggtcgcc aatgtcccca acaccagtct
     1201 gctcgtcaat atccctcagc ctacggcagc ctcactgaag gggacaacag ttggctctgc
     1261 tcaggcaaac tccactccca gcagtgtggc ttctgtggtt gcctctgctg agtccccagc
     1321 tagccggcag gctgctgcca agctagcgct gcgcaagcag ttggagaaga cactgctgga
     1381 gatcccccca cccaagcccc ctgctccgga gatgaacttc ttgcccagtg ctgccaacaa
     1441 tgaattcatc tatctggtcg gcttggagga agtggtgcag aacctgctgg agacgcaagc
     1501 gggcaggatt tctgccacct cagctgctgc cgtgttatcc cgggagcctt acatgtgtgt
     1561 gcagtgtaag acagacttca catgccgctg gcgagagaag ggtggagctg tcatgtgtga
     1621 gaactgcatg acatccaacc aaaagaaggc actaaaagtg gagcacacca gtcgcctgaa
     1681 ggccgccttc gtgaaggcgc tacaacaaga gcaggagatg gagcagcgac tgctgcagca
     1741 gggcgtaggc accgccagca tcaaggctga gaccgcagct ccacatccct cgctgaagca
     1801 ggtcataaag ccccgacgta agttggcgtt ccgctcagga gaggcccgtg actggaataa
     1861 cgggtccgta ctacagactt ccagccagct gtcccggggt tcagccacaa cacctcgtgg
     1921 tgttctgcac actttcagcc agtcacccaa actgcagaac gcagcctcag ctacggccct
     1981 ggtaagcagg actggcagac attccgagag agtcgtgggc accagcaagg gcaccgcctc
     2041 caactggaaa aagacacctc tgagcacagg tgggacgctt gccttcgtca gcccaagctt
     2101 ggcagtgcac aagagctcct cggccgtgga ccgacagcga gagtacctcc tggacatgat
     2161 tcctccacgc tccatccccc agtcagccac atggaaatag tgggagccgg cccagccgag
     2221 gacaggccct ctgctctccc gaggcccttg gtctaggaca cgcagactac cctcctagca
     2281 agttgcctga gacagctcag gccttggctc ttgccttgct gtggccagga gagtaccacc
     2341 atggtgccca ggatcagaac cagggacctt ccctatgggc cttctccttc ctttttgcct
     2401 ttagtttgcc cgacaccagc agaaactcgg accttggggc cagctctgcc tggccagcgt
     2461 gggtgggagc tcaccctgga cactgtgaca cacccgggcc agactggcac cgggggctcc
     2521 cgaagttgag ccgggatttc gttttctttt ggcttttccc atcttagctc cccagtctct
     2581 gcctcttcat ggccatctat aggttgaagt ttgggtttta ttgggttttt tgtttttgtt
     2641 ttttttataa tcacctcata atgatgatgg aattaaagtg aactgcatag acccagggtc
     2701 atggttgtgc acagtgcagt ctggcaggct ctaccccaga ggatgctcag agtggcagca
     2761 gcagagatgg caggtgccac cctggctctg gtcgtgtttg ttgctgctca ctgcagtccc
     2821 tggcttccac acttagcaga atgaaccgca gcccagatct gtctgacatc cagaggctcc
     2881 agagggatgc tggggtccgc catgctggag tcagagctga ctgctggctg ggaggctgct
     2941 gggttacttt tcgtggttta ttttattaaa aatttctatc ctttttctct tcattttgat
     3001 ggacacaatc tcaagatgcc catgcctgcc aagaggcatc caagtagggc ccagccagaa
     3061 cccttaggtc tggagtcagc agggcttact ccctcttagc cacagggatg tctgaaaggg
     3121 ctgagtctac ttttgttctg ttttgtttcc ttctccctcc actcttaaca atgggttcca
     3181 tggtgaaagg cagaagcagc tctgtgtcca gcacgcacgg tgcggccttc tgctcatgtg
     3241 attggtcgcc gtcgtttccc catccagccc tggtttccct tgacacaata cagttaggga
     3301 ctttaattta aacccttgtt ctgcagacca tcgccctctg cagacatgcc cctgcctcct
     3361 cctaataaag gctcatttaa ctccgtga
//
LOCUS       NM_001436769            3234 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 2, mRNA.
ACCESSION   NM_001436769 XM_006238353
VERSION     NM_001436769.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3234)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 3234)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3234)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3234)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 3234)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 3234)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 3234)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 3234)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 3234)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 3234)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238353.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19296.1,
                                           SRR26643295.21680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1256           JAXUCZ010000005.1  102900532-102900653 c
            1257-1312           JAXUCZ010000005.1  102898250-102898305 c
            1313-1383           JAXUCZ010000005.1  102897525-102897595 c
            1384-1485           JAXUCZ010000005.1  102897223-102897324 c
            1486-1699           JAXUCZ010000005.1  102896915-102897128 c
            1700-1811           JAXUCZ010000005.1  102895418-102895529 c
            1812-3234           JAXUCZ010000005.1  102892929-102894351 c
FEATURES             Location/Qualifiers
     source          1..3234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..3234
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1872
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 2 is encoded by transcript variant 2; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 2"
                     /protein_id="NP_001423698.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKQKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEQQTKDEGKKP
                     EVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKH
                     TEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHE
                     EANKTKDQGKKGPNKKLEKEQTGTKSLNGGSDAQESNHPQHNGDSAEESKDSREAGSK
                     TKTPGEEREAEVSLKESTLDN"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    <607..1854
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <607..1854
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1297..1530
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Integrase-binding domain (IBD).
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    1324..1629
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Lens epithelium-derived growth factor (LEDGF);
                     Region: LEDGF; pfam11467"
                     /db_xref="CDD:463284"
     misc_feature    1324..1629
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Lens epithelium-derived growth factor (LEDGF);
                     Region: LEDGF; pfam11467"
                     /db_xref="CDD:463284"
     misc_feature    1579..1581
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1588..1590
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1606..1608
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1615..1869
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1843..1845
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1858..1860
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1256
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1312
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1383
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1485
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1699
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1811
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..3234
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagcagaag
     1141 agaaagggtg gaagaaactt ccaggctgct cacaggagga acatgctaaa aggccaacat
     1201 gagaaagaag ctgcagatcg gaaacgcaag caggaggaac aaatggagac tgagcagcag
     1261 actaaagatg aaggaaagaa gccagaagtt aagaaagtgg agaagaagcg agaaacatca
     1321 atggattctc gacttcaaag gatacatgct gaaattaaaa attcactcaa aattgataat
     1381 ctagatgtga acagatgcat tgaggcactg gatgaactcg cttcacttca ggtaacaatg
     1441 caacaagctc agaaacacac agagatgatc acaaccctga agaaaatccg gcggttcaaa
     1501 gtcagtcaag ttatcatgga gaagtctaca atgttgtata acaagtttaa gaatatgttt
     1561 ttggttggtg aaggggattc cgtcatcacc caagtgctaa acaaatctct tgctgaacaa
     1621 agacagcatg aggaagcaaa taaaaccaaa gatcaaggga agaaagggcc aaacaaaaag
     1681 ctagaaaagg aacaaacagg tacaaagagc ctaaatggag gatctgatgc tcaggaaagt
     1741 aatcatccac aacataatgg tgacagtgcg gaagaaagca aagacagccg tgaggccggc
     1801 agtaagacaa agacacctgg agaagagaga gaggctgaag tatctctgaa ggagtctacc
     1861 ctagataact aggtctgcag acttcagatg taaagagtgt gagaagtctg ttgtgagtgg
     1921 cttcatttga aatacttagg ctgctgaaag gtttaaagtt ttataagcat aggttttgat
     1981 gtttaagtag ttgggggata gaaaaaccct ttatatttgt gtaaaagtca attattgcta
     2041 attttctgtg tgcagtatta acagctccgc catctagttt gagtaaggaa acctacttag
     2101 aaaggttaac ctgctttata gacatgactg tagtgaattt ttggttagtg tgtcaatgtg
     2161 taattagtag tagggcagtt acattttaaa actgctactt gtataaatct ttcctctttt
     2221 cccaaatact gtgcgttttg tgcatagttt ttacaaatat tggatttacc agactgtctt
     2281 ttcactgtgt gggtgtttta gaagttgagc atttttatgg atgataaaat gaatgttact
     2341 tctaagtact cactcccttt tatcaacagt tataacctca gtccattgtg ctacattagc
     2401 gtgcctcttt gtaataatgt gtagtatgac agctagatgc ctattgggtt gttatagaag
     2461 gtacaaattt gtttactttt aaaagtaatt tagttttagg actgggattt cagtggtgtt
     2521 agaactagag agaacagact ggttatatat acatatagga agtccatcta caatccttta
     2581 taaaggtact aatcacacaa acctaaaatt agtttgtttt aatcttatac tcattaaggt
     2641 gtgttttttt ttctttcttt tttaattaga atcaatccat gatgcttata agtaataaat
     2701 aaggaaatta acctaattga agacatggcc atattgtaat gggatttttg tttctctatc
     2761 aaacataatc agatgattac agaaaaaaca aacatcagtt gttccaaggt agtaaccaga
     2821 tagtccatat acacaaacat ggactattgc tctgttaaat taaggcataa catttcaaag
     2881 atattctgag taatcaggtc agttgttggt ctctggtagg tagaaaagtt tatccttatg
     2941 ctttgaaatt ttgtaggaag gtgacttaat accagtgttt ctgtgcgata cgattaaata
     3001 tgttcttgat ttctcagata gttattttta cctatgtaaa actttaatta ctccaattgg
     3061 actttgcttt gatagctctt acaattcact actgttttga gcaagtgctg tacattattt
     3121 acgccagtct tctgttttgt ccttagtaca tttttaactt ggacaaaaat tatcctagtt
     3181 aagccataag tgtcaatgtg taaattgttt taattaaaag gtttttctac caaa
//
LOCUS       NM_001436793            3999 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus nuclear receptor binding SET domain protein 3
            (Nsd3), transcript variant 3, mRNA.
ACCESSION   NM_001436793 XM_008771350
VERSION     NM_001436793.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3999)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   2  (bases 1 to 3999)
  AUTHORS   Rahman,S., Sowa,M.E., Ottinger,M., Smith,J.A., Shi,Y., Harper,J.W.
            and Howley,P.M.
  TITLE     The Brd4 extraterminal domain confers transcription activation
            independent of pTEFb by recruiting multiple proteins, including
            NSD3
  JOURNAL   Mol Cell Biol 31 (13), 2641-2652 (2011)
   PUBMED   21555454
REFERENCE   3  (bases 1 to 3999)
  AUTHORS   Kim,S.M., Kee,H.J., Eom,G.H., Choe,N.W., Kim,J.Y., Kim,Y.S.,
            Kim,S.K., Kook,H., Kook,H. and Seo,S.B.
  TITLE     Characterization of a novel WHSC1-associated SET domain protein
            with H3K4 and H3K27 methyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 345 (1), 318-323 (2006)
   PUBMED   16682010
REFERENCE   4  (bases 1 to 3999)
  AUTHORS   Rosati,R., La Starza,R., Veronese,A., Aventin,A., Schwienbacher,C.,
            Vallespi,T., Negrini,M., Martelli,M.F. and Mecucci,C.
  TITLE     NUP98 is fused to the NSD3 gene in acute myeloid leukemia
            associated with t(8;11)(p11.2;p15)
  JOURNAL   Blood 99 (10), 3857-3860 (2002)
   PUBMED   11986249
  REMARK    Erratum:[Blood 2002 Aug 15;100(4):1132]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_008771350.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.50999.1,
                                           SRR26643429.50972.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               JAXUCZ010000016.1  73166975-73167454   c
            481-1220            JAXUCZ010000016.1  73133777-73134516   c
            1221-1292           JAXUCZ010000016.1  73125115-73125186   c
            1293-1455           JAXUCZ010000016.1  73123928-73124090   c
            1456-1610           JAXUCZ010000016.1  73113202-73113356   c
            1611-2126           JAXUCZ010000016.1  73109120-73109635   c
            2127-2253           JAXUCZ010000016.1  73106339-73106465   c
            2254-2354           JAXUCZ010000016.1  73099673-73099773   c
            2355-2400           JAXUCZ010000016.1  73097292-73097337   c
            2401-3999           JAXUCZ010000016.1  73094784-73096382   c
FEATURES             Location/Qualifiers
     source          1..3999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..3999
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="nuclear receptor binding SET domain protein 3"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
     exon            1..480
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1220
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    504..506
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="upstream in-frame stop codon"
     CDS             525..2483
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /EC_number="2.1.1.354"
                     /note="isoform 2 is encoded by transcript variant 3;
                     histone-lysine N-methyltransferase NSD3; Wolf-Hirschhorn
                     syndrome candidate 1-like 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD3 isoform
                     2"
                     /protein_id="NP_001423722.1"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
                     /translation="MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDG
                     GPTPFEATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGA
                     VRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEI
                     KLKITKTIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEER
                     KSHKVPKLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQ
                     VGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRV
                     REYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREE
                     RVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQS
                     STDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVV
                     KIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSA
                     SPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQVETSPQASLKTGLQ
                     KGSADRGAQGSVRFSDLSVSAAKEETVD"
     misc_feature    1347..1736
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    1347..1736
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    order(1386..1388,1395..1397,1479..1481)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1386..1388,1395..1397,1479..1481)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    1389..1400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    1389..1400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1590..1598,1605..1610)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1590..1598,1605..1610)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     exon            1221..1292
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1455
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1610
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..2126
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2253
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2354
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3999
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcggag gcggcggcgg cggcgacggc agcgggagct ggcggcgcgg agatccggac
       61 ggaggccgag gctggggctg ggtgccgggc gtctgggaaa ggtgtgcagc tttctatcgg
      121 agccccggga ccccgctgcc gtttggggcc gccaacctcc ggctcctctc aggcaccagc
      181 agctacgcgg cgacccccgt ccggccgcct ccccttcgct ccgcgtcgcc cgcagccttc
      241 cgtctgcccg caaacgagcc cggccggccg ggccgtggcc ctcctcagtg ccggccgcca
      301 tggcaggggt gctcggcgcg ggggaaatct agtccgagga tttcatgcgg cctagctcgg
      361 ttccgtctcc tgcgcccgcg gtcccggcag ctgccggcaa cccagcccca cttcgggcct
      421 ccgtgtctct cctgtgatcg tactgacacg gcaggggggt tagaatggaa caaactgaag
      481 gctcgatgag agaaagggaa agttaaggat gctggagcag aacaatggat ttctctttct
      541 ctttcatgca agggatcatg ggaaacacaa ttcagcaacc acctcaactc attgactcgg
      601 ccaatatccg ccaggaggat gcctttgata acaacagtga cattgttgaa gatggtggcc
      661 cgacaccctt cgaagctact ttgcaacaag gtttccaatg tccacctgca acagaagacc
      721 ttcctccact cacaaacggc tacccaccgt ccatcagctt gtatgagact caaaccaaat
      781 acccgccata tagccagtat cccaatgggt cagccaacgg ttttggtgca gttagaaact
      841 ttagtcctac tgactattac cattcagaaa ttccaaacac aagaccacat gaaattctgg
      901 aaaaaccgtc tcccccacag cctcctcctc ctcctcttct tcctcctcct cctcctccgg
      961 taccacaaac tgtgattcca aagaagacag gctcacccga gattaaacta aaaataacca
     1021 aaactatcca gaatggcagg gaattgtttg agtcctccct ctgtggagac cttttaaacg
     1081 aagtacaggc cagtgagcac ttaaagtcaa agcacgaaag cagaaaggaa aagaggaaaa
     1141 aaagcagcag acacgagtca tcgagatccg aagagcgaaa gtcacacaag gtccccaagt
     1201 tagagccaga ggggcagaat agaccaaatg agagggtgga ccctgcacca gaaaagccaa
     1261 gagaagagcc agtgctcaaa gaggccgtcc cggttcagcc aatactgtct tctgttccaa
     1321 caacagaaac gtccactggt gttaagttcc aggttggtga tcttgtttgg tccaaggtgg
     1381 gaacctatcc ttggtggcct tgtatggttt caagtgatcc ccagcttgag gtccatacca
     1441 aaattaacac aagaggtgcc cgggagtatc atgtccagtt ttttagcaac cagccagaga
     1501 gggcatgggt tcatgagaag cgggtacggg agtataaagg tcacgaacag tatgaagagt
     1561 tactagcaga ggcagccaaa caagccagca accattctga aaagcaaaag attcggaaac
     1621 cccgacctca gagagaacgc gcccagtggg atattggcat tgctcacgca gagaaagcat
     1681 tgcagatgac acgagaggaa agggtagaac agtacacgtt catctatatc gataagcagc
     1741 cagaagagtc tccgtcccaa gcaaagaaga gtgttacctc taaggcggaa gtcaagaaac
     1801 cccgaaggcc cagatctgtg gggaacagtc agccagaaca gaccagtgct ggggaggtgg
     1861 cttccccaca gtcgagtact gaccctcgca ggcagagcca gaggcggcac accagtgtgg
     1921 aagaggacgg gccgcctccc gttaaaatag cctggagaac agccgccgcc aggaagtcct
     1981 taccagcctc catcacaatg cacaagggga gcctagatct gcacaagtgt aatatgtctc
     2041 cagttgtgaa aattgaacaa gtgtttgctc tccagaatgc aacaggagat gggaagttta
     2101 ttgatcagtt tgtttattca acgaagggaa ttggtaacaa aacagaaata agtgtcaggg
     2161 ggcaagacag gcttataatc tcttcaccaa gtcagagaaa cgagaagtcg actccgagcg
     2221 cgtcacctcc ggaggccaca tctggttctg caggcccagt agaaaagaag cagcagagaa
     2281 gatcaatcag gactcgatct gagtcagaga aatccaccga ggttgtgtca aagaagaaga
     2341 tcaaaaagga gcaggttgaa acatctcctc aggcttccct gaagaccgga ttacagaaag
     2401 ggtcggcgga ccgaggagcg cagggctctg tccgattcag tgacctctcc gtctccgcag
     2461 cgaaagagga aactgtggac tgagactcct gtacaatttc atcccagaaa ctccagactt
     2521 ggagtctccg agcaagaatt ctttgtcggc ggctcgataa agttcctttt gttttgattt
     2581 tgattttgcc aatcatcatt attggcgctc tctggcctgg tttcttcttc aagactgaac
     2641 aattgcttta acattcagat gatttctctc tatctttttt tttttttttt ttttgtccga
     2701 gctggatggg tacagcttaa atcatgggtc cagcctaaaa aaccaccatt taacttaccc
     2761 tgatcgattc caacatggac tgttttggtt tttgttttta aataaagcat cattaataca
     2821 catctgcagg gttttgccaa atggcccaaa ctgtatacat tgcaatcatt aaaagctctt
     2881 attgtttttt taacattagt gccgttatca tggagaacaa caggacagcc gccttcagcg
     2941 gtctgtcatt tttctagcat tttcagaaac tcatcggaat tggcgggacc cgtgtttccc
     3001 ttcgcaagcc tctcagtaca gcactcctgt tcttctgtta aagctccttg ttaattcagt
     3061 gatctcttag gccaaggaag tactttgtgg tggtgttctg gtcccacaca ccagcagtga
     3121 aagagtagat gtgtgtactt gtgttttcta atcagcacta acatgggcag gcaccctcat
     3181 tcgtagctgt caggcagctc tcagtgcaaa cttgtaggaa ggggtgtgct aagaaggttc
     3241 cagtaaccag agcagtctcg agaggcccac atcctcctcc acagaacgtg gccgctaaac
     3301 accaagcgct cccattcagc ctgttgcgga tctacatggc cttaggagac ttgtttctcc
     3361 acggtctctt ctggactgca cacttccgcc atagcttgct gggctgagct agatgtctgt
     3421 tcggaaagtt tgggggaagt ctaaaacaga ccgtgggtgg agatcttacc gtctccttgg
     3481 ttccttggta ttcaccgtgc ctgatctgca cagttcatcg tggctgtctc tgtatagcct
     3541 accgcattag cccaagagat tgttgctttg taactttttg cactattgtt ttggctggat
     3601 ttgtattaca cgcagtttta aaagaaaatt tccacactct tctctggctt ctttttccat
     3661 atatatatat atatttcttc tttccctcac aaagtccaga ggcctctcat ctagtccttg
     3721 gtgatttatt gcacttggac cctgattgtc catcacagcc ctcagtgatg tgcctcccac
     3781 atggcatgac atgtgtagat gtgccgcagc acttgttaac ggtcacaata aatgccactt
     3841 taccaagaaa gaacaattat gaaaatccaa aattttattg gggggataat caaccgaatt
     3901 gcaaaattgg ggggttgaaa tggcactatc cgtgtacgaa tcgaatacaa atcaaagatt
     3961 tgtcacatcc ctaataaagc aagatggaga tgtctctgc
//
LOCUS       NM_001436827            2194 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus R-spondin 1 (Rspo1), transcript variant 3, mRNA.
ACCESSION   NM_001436827
VERSION     NM_001436827.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Li,J.Y., Wu,X., Lee,A., Zhou,S.Y. and Owyang,C.
  TITLE     Altered R-spondin 1/CART neurocircuit in the hypothalamus
            contributes to hyperphagia in diabetes
  JOURNAL   J Neurophysiol 121 (3), 928-939 (2019)
   PUBMED   30649980
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Szenker-Ravi,E., Altunoglu,U., Leushacke,M., Bosso-Lefevre,C.,
            Khatoo,M., Thi Tran,H., Naert,T., Noelanders,R., Hajamohideen,A.,
            Beneteau,C., de Sousa,S.B., Karaman,B., Latypova,X., Basaran,S.,
            Yucel,E.B., Tan,T.T., Vlaminck,L., Nayak,S.S., Shukla,A.,
            Girisha,K.M., Le Caignec,C., Soshnikova,N., Uyguner,Z.O.,
            Vleminckx,K., Barker,N., Kayserili,H. and Reversade,B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. doi:
            10.1038/s41586-018-0296-7. PMID: 29977062]
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Li,J.Y., Chai,B., Zhang,W., Fritze,D.M., Zhang,C. and
            Mulholland,M.W.
  TITLE     LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food
            intake in the hypothalamus of male rats
  JOURNAL   Endocrinology 155 (2), 429-440 (2014)
   PUBMED   24280058
  REMARK    GeneRIF: These data indicate that Rspo1 and Rspo3 and their
            receptor LGR4 form novel circuits in the brain to regulate energy
            homeostasis.
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Niehrs,C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   5  (bases 1 to 2194)
  AUTHORS   Ruffner,H., Sprunger,J., Charlat,O., Leighton-Davies,J.,
            Grosshans,B., Salathe,A., Zietzling,S., Beck,V., Therier,M.,
            Isken,A., Xie,Y., Zhang,Y., Hao,H., Shi,X., Liu,D., Song,Q.,
            Clay,I., Hintzen,G., Tchorz,J., Bouchez,L.C., Michaud,G., Finan,P.,
            Myer,V.E., Bouwmeester,T., Porter,J., Hild,M., Bassilana,F.,
            Parker,C.N. and Cong,F.
  TITLE     R-Spondin potentiates Wnt/beta-catenin signaling through orphan
            receptors LGR4 and LGR5
  JOURNAL   PLoS One 7 (7), e40976 (2012)
   PUBMED   22815884
REFERENCE   6  (bases 1 to 2194)
  AUTHORS   Carmon,K.S., Gong,X., Lin,Q., Thomas,A. and Liu,Q.
  TITLE     R-spondins function as ligands of the orphan receptors LGR4 and
            LGR5 to regulate Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11452-11457 (2011)
   PUBMED   21693646
REFERENCE   7  (bases 1 to 2194)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2194)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   9  (bases 1 to 2194)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 2194)
  AUTHORS   Kamata,T., Katsube,K., Michikawa,M., Yamada,M., Takada,S. and
            Mizusawa,H.
  TITLE     R-spondin, a novel gene with thrombospondin type 1 domain, was
            expressed in the dorsal neural tube and affected in Wnts mutants
  JOURNAL   Biochim Biophys Acta 1676 (1), 51-62 (2004)
   PUBMED   14732490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1530093.1,
                                           SRR21887623.3215805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-578               JAXUCZ010000005.1  142536344-142536921
            579-923             JAXUCZ010000005.1  142540850-142541194
            924-1115            JAXUCZ010000005.1  142553443-142553634
            1116-1265           JAXUCZ010000005.1  142555616-142555765
            1266-1454           JAXUCZ010000005.1  142556063-142556251
            1455-2194           JAXUCZ010000005.1  142556872-142557611
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2194
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="R-spondin 1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
     exon            1..578
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            579..923
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    761..763
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="upstream in-frame stop codon"
     CDS             830..1618
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /codon_start=1
                     /product="R-spondin-1 precursor"
                     /protein_id="NP_001423756.1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
                     /translation="MRLGLCVVALVLSWTHLAVGSRGIKGKRQRRISAEGSQSCAKGC
                     ELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHC
                     EACFSHNFCTKCQEGLYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCS
                     KKRKLCGFRKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRRTPCPEGQKRKKASQG
                     RRENANRHPTRKNSKEPGSNSRRHKGQQQPQPGTAGPLTSVGPT"
     sig_peptide     830..889
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    953..1255
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    953..1255
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    1271..1438
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    1271..1438
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     exon            924..1115
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1265
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1454
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..2194
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccggg cggcggactg cggggcccgc gcgggccgcc ccagcaccaa tgcgccgggc
       61 ggggcgctgg cggccgagaa ggcattgagc aaccgggcag cgggcggagc gcggggccga
      121 cggcaacgcg ggacccaata gccgcgccgt cgcccctccg ggctgccccg ccacggccgc
      181 tgcgccaggt gagtcccgcg gcccgcgcgg tctgccccga ggtcctgggt cccggtcgga
      241 gcgcagccgg agccagggag gcagggcaga acccgacccc atcccttcgt cccgcatcag
      301 cccgggacac cccgccccga gtccccagcc gcgacattcc cgccccagcc gtgcccccac
      361 gcaccgcagc ggcaacccag ctgtgaccca accctgaccc acgcgaccca gccccgcctc
      421 aagtccccag ccccaaccca gtcccccccc acccagcctt gcccacatcc cagatgcaac
      481 ccagctgcga cccagcccca tctggagtcc ctagcctcga cccacgcgac ccacgcaccc
      541 tagctgcgac ccagccccga cccacgcgac ctagtccggt ctgtcttgag ggtggttctc
      601 tgctggcgtg agaagacttc tcatgtgacc ctctgaggtg gcttcaagca ggacaggacc
      661 tccctttgga ccgatggaga acctggctcc attccccctc agatcccagc tgaggttatg
      721 gtggatctgg cctgcagcct gggcctgggt cccctgccac tgacccagcc tcagagccta
      781 tagcaagaga ccacccctcc tgcaaggggc ccggggctgg ccagtgacta tgcggcttgg
      841 gctgtgtgtg gtggccctgg ttctgagctg gacacacctc gctgtgggca gccgggggat
      901 caagggcaag agacagaggc ggatcagtgc tgaggggagc caatcttgtg ccaagggctg
      961 tgagctctgt tcagaagtca acggttgcct caaatgctcg cccaagctct tcattctgct
     1021 ggagaggaac gacatccgcc aggtgggcgt ctgcctgccg tcctgcccgc ctggatactt
     1081 tgatgcccgc aaccccgaca tgaacaaatg catcaaatgc aagattgagc actgtgaggc
     1141 ctgcttcagc cacaacttct gcaccaagtg tcaggagggc ttgtacttac acaagggccg
     1201 ctgctatcca gcctgtcccg agggttccac agcagccaac agcaccatgg agtgcggcag
     1261 tcctgcacaa tgtgaaatga gcgagtggtc accgtggggc ccctgctcca agaagaggaa
     1321 gctgtgtggt ttccggaagg gatcggaaga gcggacacgc agggtgctcc atgctcctgg
     1381 aggagaccaa accaactgct cagacaccaa agagacccgg aagtgtaccg tgcgcaggac
     1441 gccctgccct gaggggcaga agaggaagaa ggcgagccag ggccggaggg agaatgccaa
     1501 taggcacccg accaggaaga acagcaagga gccaggctcc aactctcgga gacacaaagg
     1561 ccagcagcag ccacagccag ggacagcagg gccactcaca tcagtaggcc ccacctaggc
     1621 acagtgacca gtctccagtt acgtgtggaa gaatccagtg ctgtgagaac tttccagaac
     1681 tggagcatct gggaaagaaa gtccacacat accccattca cccacccatc catctatcca
     1741 tgcatccatg cacacatatg gccacatctg aaaacttcca cacacgcgcg cacacacaca
     1801 cacacacaca cacacacaca cacacacaca cacacacaca cacactcttg aggtcacaga
     1861 agatatttcc attctgtggc ccagctgtat attcagccta ggatgctctt agaaggcgta
     1921 actgagagaa cctttcccag cacctgaagc taaacttcaa tgcgtggaac cttctggagg
     1981 aacttctggg acagcatctg ccagatggac ggcagattgg aaccaaaact ggagcagctg
     2041 ccgaggggaa gaatgctctc cctgtcctga gaggcactcc cagcttcgag acttgattgt
     2101 tggagaatca ttacacatcc ggggtgcacg tcacggctga cctgacttgg aaactgcgta
     2161 aaggtttatt tcaaattaaa aagagagaaa caaa
//
LOCUS       NM_001436810            4543 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus lysine demethylase 4A (Kdm4a), transcript variant
            2, mRNA.
ACCESSION   NM_001436810 XM_006238668
VERSION     NM_001436810.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4543)
  AUTHORS   Li,L., Ding,Z., Ma,F., Zhang,K., Lu,D., Wang,H. and Yang,K.
  TITLE     Spinal nerve transection-induced upregulation of KDM4A in the
            dorsal root ganglia contributes to the development and maintenance
            of neuropathic pain via promoting CCL2 expression in rats
  JOURNAL   Eur J Neurosci 60 (6), 5169-5188 (2024)
   PUBMED   39136140
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of KDM4A in
            the dorsal root ganglia contributes to the development and
            maintenance of neuropathic pain via promoting CCL2 expression in
            rats.
REFERENCE   2  (bases 1 to 4543)
  AUTHORS   Li,W., Zhang,Y., Lv,J., Zhang,Y., Bai,J., Zhen,L. and He,X.
  TITLE     MicroRNA-137-mediated lysine demethylase 4A regulates the recovery
            of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis
  JOURNAL   Int J Neurosci 133 (1), 37-50 (2023)
   PUBMED   33499717
  REMARK    GeneRIF: MicroRNA-137-mediated lysine demethylase 4A regulates the
            recovery of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis.
REFERENCE   3  (bases 1 to 4543)
  AUTHORS   Liu,Y., Zhao,L., Zhang,J., Lv,L., Han,K., Huang,C. and Xu,Z.
  TITLE     Histone Demethylase KDM4A Inhibition Represses Neuroinflammation
            and Improves Functional Recovery in Ischemic Stroke
  JOURNAL   Curr Pharm Des 27 (21), 2528-2536 (2021)
   PUBMED   33402077
  REMARK    GeneRIF: Histone Demethylase KDM4A Inhibition Represses
            Neuroinflammation and Improves Functional Recovery in Ischemic
            Stroke.
REFERENCE   4  (bases 1 to 4543)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   5  (bases 1 to 4543)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 4543)
  AUTHORS   Sohi,G., Marchand,K., Revesz,A., Arany,E. and Hardy,D.B.
  TITLE     Maternal protein restriction elevates cholesterol in adult rat
            offspring due to repressive changes in histone modifications at the
            cholesterol 7alpha-hydroxylase promoter
  JOURNAL   Mol Endocrinol 25 (5), 785-798 (2011)
   PUBMED   21372147
REFERENCE   7  (bases 1 to 4543)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 4543)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 4543)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
REFERENCE   10 (bases 1 to 4543)
  AUTHORS   Zhang,D., Yoon,H.G. and Wong,J.
  TITLE     JMJD2A is a novel N-CoR-interacting protein and is involved in
            repression of the human transcription factor achaete scute-like
            homologue 2 (ASCL2/Hash2)
  JOURNAL   Mol Cell Biol 25 (15), 6404-6414 (2005)
   PUBMED   16024779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238668.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28610.1,
                                           SRR26643295.22389.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000005.1  137004508-137004563 c
            57-238              JAXUCZ010000005.1  137002124-137002305 c
            239-414             JAXUCZ010000005.1  137000421-137000596 c
            415-529             JAXUCZ010000005.1  136994699-136994813 c
            530-723             JAXUCZ010000005.1  136993217-136993410 c
            724-773             JAXUCZ010000005.1  136991038-136991087 c
            774-877             JAXUCZ010000005.1  136989469-136989572 c
            878-1015            JAXUCZ010000005.1  136988994-136989131 c
            1016-1260           JAXUCZ010000005.1  136986918-136987162 c
            1261-1460           JAXUCZ010000005.1  136986178-136986377 c
            1461-1828           JAXUCZ010000005.1  136983358-136983725 c
            1829-1949           JAXUCZ010000005.1  136975431-136975551 c
            1950-2131           JAXUCZ010000005.1  136971303-136971484 c
            2132-2336           JAXUCZ010000005.1  136969629-136969833 c
            2337-2413           JAXUCZ010000005.1  136969129-136969205 c
            2414-2469           JAXUCZ010000005.1  136968639-136968694 c
            2470-2578           JAXUCZ010000005.1  136966908-136967016 c
            2579-2764           JAXUCZ010000005.1  136966445-136966630 c
            2765-2935           JAXUCZ010000005.1  136963305-136963475 c
            2936-3055           JAXUCZ010000005.1  136960072-136960191 c
            3056-3148           JAXUCZ010000005.1  136959687-136959779 c
            3149-4543           JAXUCZ010000005.1  136958178-136959572 c
FEATURES             Location/Qualifiers
     source          1..4543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4543
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="lysine demethylase 4A"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
     exon            1..56
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            57..238
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3289
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /EC_number="1.14.11.-"
                     /note="isoform a is encoded by transcript variant 2;
                     lysine-specific demethylase 4A; jumonji domain containing
                     2A; lysine (K)-specific demethylase 4A"
                     /codon_start=1
                     /product="lysine-specific demethylase 4A isoform a"
                     /protein_id="NP_001423739.1"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
                     /translation="MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGL
                     AKVVPPKEWKPRTSYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIAN
                     SDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLV
                     EKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKR
                     LERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYH
                     AGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKA
                     GKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEECPEEDSEAAEQGEEGDVKRSLAKHR
                     IGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECQATLAPVRPTHSSVRQVEDSL
                     PFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAALDLSVNPESVEGRLVFSGSKKKAS
                     SSLGSSSSQDSVSSDSETTESVSCQGQEKTVLTVHSYSRGDGKAAPGEPSVKRQRSAP
                     RSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTP
                     EEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNELMAQQAPHCAVCMIFQTYHQVEFGG
                     FSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCS
                     VRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAV
                     AILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHV
                     SCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQ
                     CEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYG
                     AKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTE
                     KEVKQEKKRQRVINSRYREDYIEPALYRAIME"
     misc_feature    137..265
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Small domain found in the jumonji family of
                     transcription factors; Region: JmjN; smart00545"
                     /db_xref="CDD:128818"
     misc_feature    137..265
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Small domain found in the jumonji family of
                     transcription factors; Region: JmjN; smart00545"
                     /db_xref="CDD:128818"
     misc_feature    623..973
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    623..973
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    2093..2392
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    2093..2392
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    order(2093..2095,2294..2308,2318..2320,2375..2377)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    order(2093..2095,2294..2308,2318..2320,2375..2377)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    2417..2746
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    2417..2746
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    order(2579..2581,2621..2635,2651..2653,2729..2731)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    order(2579..2581,2621..2635,2651..2653,2729..2731)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    2789..2953
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    2789..2953
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    order(2885..2890,2894..2905,2909..2911)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    order(2885..2890,2894..2905,2909..2911)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    2960..3127
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    2960..3127
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    order(2993..3001,3011..3013)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     misc_feature    order(2993..3001,3011..3013)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     exon            239..414
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            415..529
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            530..723
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            724..773
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            774..877
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1015
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1260
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1460
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1828
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1949
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2131
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2336
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2413
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2469
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2578
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2764
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2935
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3055
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3148
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..4543
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcctgcgg ccgggcctcc ctcgtctagg cggtggggcc gggaggggca gtgtctggtt
       61 ttatctgagc ctcaaaaaag aagaacaaaa gaagaacaaa atggcttctg aatcggaaac
      121 tttgaacccc agcgctcgga tcatgacgtt ttaccccacc atggaagagt ttcgaaactt
      181 cagccgatac attgcctaca ttgaatccca aggagctcat cgggctgggc tagccaaggt
      241 tgttcctccc aaagaatgga agcctcgaac ctcctatgat gacatcgacg atctggtcat
      301 ccctgcaccc atccagcagc tggtgactgg ccagtccggc ctcttcactc agtacaatat
      361 acagaagaaa gccatgactg ttcgtgagtt ccgcaagatc gccaatagtg acaagtactg
      421 tactccacgg tatagtgaat ttgaagaact tgagcgtaaa tactggaaaa acctcacatt
      481 caatcctccc atctatggag cagatgtgaa tggtactctc tatgaacagc acgttgatga
      541 gtggaacatc ggccggctga agaccatcct ggacctggtg gagaaggaga gtgggatcac
      601 catcgagggc gtgaacaccc cctacctgta ctttggcatg tggaagacgt cctttgcctg
      661 gcacacggaa gacatggatc tgtacagcat caactacctg cactttggag agccaaagtc
      721 ttggtactct gttccacctg agcatgggaa acgcctggag cggctcgcca aaggcttttt
      781 cccaggaagt gctcaaagct gtgaggcttt tctccgccac aagatgaccc tgatctcccc
      841 attaatgctg aagaagtatg gcattccctt tgacaaggtg acccaagaag ccggggagtt
      901 tatgatcact tttccatatg ggtaccatgc tggtttcaac catggcttca actgtgcaga
      961 gtctaccaat tttgctaccc gtcggtggat tgaatatggc aagcaggctg tactgtgttc
     1021 ctgcagaaaa gatatggtga agatctctat ggacgtgttt gtcaggaggt tccagccgga
     1081 acgctacaaa ctttggaaag ctgggaaaga cagcactgtt attgaccaca ctctgcccac
     1141 accggaagca gctgagtttc tgaaggacag tggactaacc ccaagagctg ggaatgagga
     1201 gtgcccagag gaggactcgg aagcggcgga gcagggagag gagggggatg tgaagagaag
     1261 cctggctaag caccgaatag ggacaaagag acaccgagtc tgtctggaaa taccacagga
     1321 ggtcagtcag agcgagctct tccccaagga agagctgagt tctggacagt atgagatgac
     1381 agagtgccag gccaccctcg ccccagtgag gcccacccac agctccgtgc ggcaagttga
     1441 ggacagcctt cccttcccag attactccga ccccactgag gtcaaattcg aagagctgaa
     1501 gaacgtcaaa ctagaagagg aggatgagga tgaggagccg gaagcagctg cactggacct
     1561 ttctgtgaat cccgagtctg tagaaggacg cctcgtcttc tcgggctcca aaaagaaagc
     1621 ctcctccagc ctaggctcca gttcctctca ggattcagtt tcttcagatt ccgaaaccac
     1681 cgagtctgtc tcttgccagg gccaagagaa aacagttctc acggtgcaca gctactccag
     1741 aggagatggc aaggctgccc caggcgagcc gagtgtgaag aggcagcgca gcgccccccg
     1801 cagcatcagc gagcaggagc tggcagaggt tgcagatgag tacatgctct ccctggagga
     1861 gaataagaag accaagggtc gccgccagcc cttgagcaag ctcccacgcc atcacccgct
     1921 ggtgttgcag gagtgcggca gcgatgacga gacttctgaa cagctgacac ccgaggaaga
     1981 ggctgaggag accgaggctt gggctaagcc tctgagccag ctgtggcaga accgacctcc
     2041 aaactttgag gctgaaaagg aattcaatga gctcatggcc cagcaggccc ctcactgtgc
     2101 tgtgtgtatg atcttccaga cctaccatca ggtggaattt ggaggcttca gtcagagctg
     2161 tgggaatgct tcagaaccag ctgcccaacc tcagaggact aagccattga tccccgaaat
     2221 gtgctttacc acaactggct gcagcacaga catcaatctg tccacccctt acctagagga
     2281 ggatggcacc agcatgctgg tgtcttgtaa gaagtgcagt gtccgggtcc acgccagttg
     2341 ctatggcgtc ccccctgcaa aggcttctga agaatggatg tgctctcgat gttcagccaa
     2401 tgccctggag gaagactgct gtttatgctc actgcgtgga ggggccctgc agagagcaaa
     2461 cgacgacaga tgggttcatg tttcatgtgc tgtggcaatt ctagaagcaa ggtttgtcaa
     2521 cattgctgaa agaagtccag tggatgtgag caaaatccct ctgccccgct tcaaactgaa
     2581 gtgtgtcttt tgtaagaagc gaagaaaacg gaatgctggc tgttgtgtgc agtgctctca
     2641 cggccgctgc cccactgcct tccatgtgag ctgtgcccag gctgccgggg tgatgatgca
     2701 acccgatgac tggccttttg ttgtcttcat cacgtgcttc cgccacaaga ttcccaattt
     2761 ggagcgagct aagggagcct tgctgagcat cacggccggc cagaaggtca tcagcaagca
     2821 caagaacggc cgcttctacc agtgcgaggt ggtcagactc accaccgaaa ccttctacga
     2881 agtcaacttt gatgacggct ccttcagcga caacctttat cctgaggaca tagtgagtca
     2941 ggactgtctc caactggggc ctcctgctga aggcgaagtg gttcaagtca gatggacaga
     3001 tggtcaagtc tatggggcta agtttgtggc ctcccacccc atccagatgt accaggtgga
     3061 gttcgaggat ggctcgcagc tggtggttaa gagagatgat gtatacacac tggatgaaga
     3121 gcttcccaag agagtcaagt ctagactgtc agtagcttca gacatgcggt tcaatgagat
     3181 tttcacagag aaggaagtaa agcaagaaaa gaaaaggcaa cgggtcatca actcaaggta
     3241 ccgggaggat tacatcgagc cagcactgta tcgggccatc atggagtaga cgtttcccgg
     3301 gtctgagagg tcccagccat caaggcgaga acactctcgg gttccacagc acagcagaca
     3361 cttggaactc agaagtctta gaaagagaag ctgtacaaag aaaaggaatg acatgtctga
     3421 cccatcacct tctcactcct ccttcaatga attctgccgt gaaaagacaa gccgggcgct
     3481 tggcagcagc tgacgctgac actgggatgc tgtgactcca tcagcgccca gtccaaaccg
     3541 gtcagctgtt cctgctgggc ggattgttgt ttcttagcct aggactagct tcctaccacc
     3601 cacctgcacc agcaaggcag agaggtgctg gtgctcaacc caatcccctt ttgtatttat
     3661 gtatgagtgt gtgagtgcac gcatgtacag gtgtgtacct gtgtgagagc gctcgagtgt
     3721 gcacctgtgt gcttgagaat gtgtgggtgt gcaagcacgt gtgtgtgtgt gtgcgcgagt
     3781 gcctgtgtgc atgagtgcat gagtgtgtgt gtgggagtgt gcttgatctg gactagcttc
     3841 agccagcccc tgggcttcac tttctccttt gcctctgcag ggcaaacaaa atgtgaaatt
     3901 ctgccctcag ctaagctgag taagggccct gggggatggc tagaggttgg ttgccatctg
     3961 tcccttcctg gaccgatttc aagagagtgc tggcaaagct gcagtattgg gatgctaagg
     4021 agctgactgc cacctctgtc cacccttgga gtagaactca gaggttctgt actatgagcc
     4081 cacaaacttc aggcacggaa gcccctgtgg cagtgttaga gggtgtgggt ggggcctacc
     4141 ttgaagggag aattttaatg atggaaacag gcagagcctg gtgggtaatt tttgtgcagg
     4201 ggaaaaaatt gcagttatgc aggggctatc tgtgggttag gatgaactgg ggccactgga
     4261 ggccaagggc aggtgtagcc acgcccttgg tcaggggtgg ggtggggctg attgagggtg
     4321 ggggggtggg actggagggc aacattgaag gggttaaaca ggtttttgct cctcttgaat
     4381 ttgtttgcct gggcccaata ttggagggct tcataccttg ctctgtatac aggagtcaga
     4441 tttataatac ttcccctttt ttgttacgta tgaactctat aaaccaaatt attttgaaaa
     4501 ctggtgcatt accttgtcct tagcaataaa atgtattgag cag
//
LOCUS       NM_001014001            2083 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 5, mRNA.
ACCESSION   NM_001014001 XM_224861
VERSION     NM_001014001.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2083)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001014001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082052.1, SRR26643293.74872.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000016.1  52856873-52857039   c
            168-1264            JAXUCZ010000016.1  52848306-52849402   c
            1265-1533           JAXUCZ010000016.1  52836572-52836840   c
            1534-1684           JAXUCZ010000016.1  52822585-52822735   c
            1685-1791           JAXUCZ010000016.1  52821565-52821671   c
            1792-2083           JAXUCZ010000016.1  52818692-52818983   c
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2083
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..167
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            168..1264
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1830
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 2"
                     /protein_id="NP_001014023.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQNDDDFKEG
                     INKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKPKFPSKE
                     QHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYYTDGEES
                     SDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIGSDMQNK
                     PDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPASTPDSSP
                     AQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQNFAPKSS
                     VLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNYSFTREE
                     VRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQRIERENM
                     ALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRGASRTSS
                     ATSGLSCKTDRSVLDTSSGFLLRPKPPNIQCSNSKVLRSH"
     misc_feature    205..207
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    238..240
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    436..1074
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    646..648
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    661..663
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    664..666
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    886..888
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    958..960
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    1246..1554
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1246..1554
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1402..1476
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1672..1827
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1265..1533
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1684
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1791
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2083
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaacccga acgctcggcg cggcgcgaga gtcggtagcg gccacagttc ccaggtgagc
       61 ggctcacggg cttccgcatc cggtcggtct ccagcgggcg agacgccctc ctctgcgttc
      121 ggggtccgtt tccccggttc ggtgcccgac ggaggcgagc acccaggata tacttttggc
      181 atcatggatc ggtttggcga tatctcagaa ggtgaagtgg accattcttt ctttgacagt
      241 gattttgaag acacaaagaa atgtgaaagt aattccattt ttgacaagca aaatgatgat
      301 gactttaagg aaggaataaa taaggacatc aaaaatttaa acttgaaatt tggagtacaa
      361 aatgataacc ttaaagagaa aatagataat gacacagaaa atgtgaacgt gaaacttggg
      421 atacaaacaa aggaaaatta ccttactcag aagggaaatg aaaggaaacc aaaatttccc
      481 tcaaaggaac aacatgtaga aaatgaccct atacaaacaa gaagtccctc attgttgact
      541 tcttcaaggt caaaaaaact gtgtgatacc acaaaaggaa ataaactaca tttgcctgtt
      601 ccaaatagaa ttcctaaaat tgtgaaaggt gaggatgact actacacaga tggagaggaa
      661 agcagtgacg atgggaagaa gtaccacgtg aggtctaagt cagcgaagcc ctctagtaac
      721 ttaaaaaaga acaacacaag taagaagtat tccaaagcca gttcctcctc tctgtcttcc
      781 tcatcttcac gatcaagctc agactgctca gatataggat ctgacatgca aaataaacct
      841 gattcaggtt catcagggaa acgagtttct agtgtaaccc cctcatcacc aaagcagaag
      901 tgtaagtcag gaagaaaatc aagtgctaaa cagaaggcag gtgactataa tgcagagtca
      961 gaagacaacg taacagacgt aactcccgcg tcaactccag acagcagccc tgcccagcca
     1021 tttgagttga gccaatcaca gaatcaaaaa gtaaaagtta aaagacaaga aaatgtgagc
     1081 cgggatgtgt atgaggatgt ggaggcttta aagaatgatt caagatgtct gaaatcagcc
     1141 aaaaggaaag aaaagcatgg acagaatttt gctccaaaat catcagtgtt agatgcaaat
     1201 ctagaccgta gatccaagca aaaagtctta catgacacaa tggaccttaa tcatctgttg
     1261 aaagctttcc tgcagttaga taaaaaggga ccacagaaac atcactttga gcagccttca
     1321 ataataccta ggaaaaacta ctctttcaca agagaagagg tgagacagat tgatcgggag
     1381 aatcagaggc ttttgaaaga actgtcaaga caggctgaaa aaccaggaaa caaaagtaca
     1441 attcctggaa gatcgctcgg ccatccacct aagttgtatc acagtgctct caacagacag
     1501 agggaacagc aaaggattga aagagaaaat atggctttat tgaaacggct tgaagctgtg
     1561 aagccaacag ttggcatgaa acgctctgaa cagctgatgg actaccatcg gaatatcagt
     1621 tacctcaacc cttcaccgtc cgtcagacga gtgagatcta ctcttggcca ttacagccca
     1681 ctgagaggag cttccaggac atccagtgca accagtggtc tcagttgtaa gactgatcga
     1741 tcagtgttgg acacatccag tggctttttg ctaagaccga aacccccgaa tatacaatgc
     1801 agcaactcca aagtattaag atcacactaa gctgaagatg cacctttgcc ctggttagca
     1861 acgcaaaacc gtatcgtcat acatgccaag gccttagcgt gtagatgtct gtacaccggc
     1921 acagcgaatg agctcactgc taatggctga gttgcttatt ttcatgaaca aagattagca
     1981 agaaactgtt aaaccatctt tttaaaaact gttctagttt gtcatatttt aggcatgaag
     2041 aactagcttg gcttactgaa gaaataaaag atttaaagag aac
//
LOCUS       NM_001436790            3412 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 17, mRNA.
ACCESSION   NM_001436790 XM_063275207
VERSION     NM_001436790.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3412)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3412)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3412)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275207.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74317.1,
                                           SRR26643429.50357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1153           JAXUCZ010000016.1  19544907-19545038
            1154-1318           JAXUCZ010000016.1  19545145-19545309
            1319-1598           JAXUCZ010000016.1  19546706-19546985
            1599-1900           JAXUCZ010000016.1  19548553-19548854
            1901-2093           JAXUCZ010000016.1  19549883-19550075
            2094-3412           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3412
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2224
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 7 is encoded by transcript variant 17; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 7"
                     /protein_id="NP_001423719.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQTSSQLSRGSAT
                     TPRGVLHTFSQSPKLQNAASATALVSRTGRHSERVVGTSKGTASNWKKTPLSTGGTLA
                     FVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1655..1756
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1655..1756
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1153
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1318
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1598
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1900
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2093
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..3412
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc cagattcaca acatcagaca gcattcctcc acggggccac cacccctcct
     1201 cctggccccc cgtgcctcag tgcccagcat gcagattcag ggacagagga tcatccagca
     1261 gggactcatc cgggtcgcca atgtccccaa caccagtctg ctcgtcaata tccctcagcc
     1321 tacggcagcc tcactgaagg ggacaacagt tggctctgct caggcaaact ccactcccag
     1381 cagtgtggct tctgtggttg cctctgctga gtccccagct agccggcagg ctgctgccaa
     1441 gctagcgctg cgcaagcagt tggagaagac actgctggag atccccccac ccaagccccc
     1501 tgctccggag atgaacttct tgcccagtgc tgccaacaat gaattcatct atctggtcgg
     1561 cttggaggaa gtggtgcaga acctgctgga gacgcaagcg ggcaggattt ctgccacctc
     1621 agctgctgcc gtgttatccc gggagcctta catgtgtgtg cagtgtaaga cagacttcac
     1681 atgccgctgg cgagagaagg gtggagctgt catgtgtgag aactgcatga catccaacca
     1741 aaagaaggca ctaaaagtgg agcacaccag tcgcctgaag gccgccttcg tgaaggcgct
     1801 acaacaagag caggagatgg agcagcgact gctgcagcag ggcgtaggca ccgccagcat
     1861 caaggctgag accgcagctc cacatccctc gctgaagcag acttccagcc agctgtcccg
     1921 gggttcagcc acaacacctc gtggtgttct gcacactttc agccagtcac ccaaactgca
     1981 gaacgcagcc tcagctacgg ccctggtaag caggactggc agacattccg agagagtcgt
     2041 gggcaccagc aagggcaccg cctccaactg gaaaaagaca cctctgagca caggtgggac
     2101 gcttgccttc gtcagcccaa gcttggcagt gcacaagagc tcctcggccg tggaccgaca
     2161 gcgagagtac ctcctggaca tgattcctcc acgctccatc ccccagtcag ccacatggaa
     2221 atagtgggag ccggcccagc cgaggacagg ccctctgctc tcccgaggcc cttggtctag
     2281 gacacgcaga ctaccctcct agcaagttgc ctgagacagc tcaggccttg gctcttgcct
     2341 tgctgtggcc aggagagtac caccatggtg cccaggatca gaaccaggga ccttccctat
     2401 gggccttctc cttccttttt gcctttagtt tgcccgacac cagcagaaac tcggaccttg
     2461 gggccagctc tgcctggcca gcgtgggtgg gagctcaccc tggacactgt gacacacccg
     2521 ggccagactg gcaccggggg ctcccgaagt tgagccggga tttcgttttc ttttggcttt
     2581 tcccatctta gctccccagt ctctgcctct tcatggccat ctataggttg aagtttgggt
     2641 tttattgggt tttttgtttt tgtttttttt ataatcacct cataatgatg atggaattaa
     2701 agtgaactgc atagacccag ggtcatggtt gtgcacagtg cagtctggca ggctctaccc
     2761 cagaggatgc tcagagtggc agcagcagag atggcaggtg ccaccctggc tctggtcgtg
     2821 tttgttgctg ctcactgcag tccctggctt ccacacttag cagaatgaac cgcagcccag
     2881 atctgtctga catccagagg ctccagaggg atgctggggt ccgccatgct ggagtcagag
     2941 ctgactgctg gctgggaggc tgctgggtta cttttcgtgg tttattttat taaaaatttc
     3001 tatccttttt ctcttcattt tgatggacac aatctcaaga tgcccatgcc tgccaagagg
     3061 catccaagta gggcccagcc agaaccctta ggtctggagt cagcagggct tactccctct
     3121 tagccacagg gatgtctgaa agggctgagt ctacttttgt tctgttttgt ttccttctcc
     3181 ctccactctt aacaatgggt tccatggtga aaggcagaag cagctctgtg tccagcacgc
     3241 acggtgcggc cttctgctca tgtgattggt cgccgtcgtt tccccatcca gccctggttt
     3301 cccttgacac aatacagtta gggactttaa tttaaaccct tgttctgcag accatcgccc
     3361 tctgcagaca tgcccctgcc tcctcctaat aaaggctcat ttaactccgt ga
//
LOCUS       NM_001436792            3923 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus nuclear receptor binding SET domain protein 3
            (Nsd3), transcript variant 2, mRNA.
ACCESSION   NM_001436792
VERSION     NM_001436792.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Rahman,S., Sowa,M.E., Ottinger,M., Smith,J.A., Shi,Y., Harper,J.W.
            and Howley,P.M.
  TITLE     The Brd4 extraterminal domain confers transcription activation
            independent of pTEFb by recruiting multiple proteins, including
            NSD3
  JOURNAL   Mol Cell Biol 31 (13), 2641-2652 (2011)
   PUBMED   21555454
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Kim,S.M., Kee,H.J., Eom,G.H., Choe,N.W., Kim,J.Y., Kim,Y.S.,
            Kim,S.K., Kook,H., Kook,H. and Seo,S.B.
  TITLE     Characterization of a novel WHSC1-associated SET domain protein
            with H3K4 and H3K27 methyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 345 (1), 318-323 (2006)
   PUBMED   16682010
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Rosati,R., La Starza,R., Veronese,A., Aventin,A., Schwienbacher,C.,
            Vallespi,T., Negrini,M., Martelli,M.F. and Mecucci,C.
  TITLE     NUP98 is fused to the NSD3 gene in acute myeloid leukemia
            associated with t(8;11)(p11.2;p15)
  JOURNAL   Blood 99 (10), 3857-3860 (2002)
   PUBMED   11986249
  REMARK    Erratum:[Blood 2002 Aug 15;100(4):1132]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1488534.1,
                                           SRR26360186.2158604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               JAXUCZ010000016.1  73167710-73168113   c
            405-1144            JAXUCZ010000016.1  73133777-73134516   c
            1145-1216           JAXUCZ010000016.1  73125115-73125186   c
            1217-1379           JAXUCZ010000016.1  73123928-73124090   c
            1380-1534           JAXUCZ010000016.1  73113202-73113356   c
            1535-2050           JAXUCZ010000016.1  73109120-73109635   c
            2051-2177           JAXUCZ010000016.1  73106339-73106465   c
            2178-2278           JAXUCZ010000016.1  73099673-73099773   c
            2279-2324           JAXUCZ010000016.1  73097292-73097337   c
            2325-3923           JAXUCZ010000016.1  73094784-73096382   c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..3923
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="nuclear receptor binding SET domain protein 3"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
     exon            1..404
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..1144
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    428..430
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="upstream in-frame stop codon"
     CDS             449..2407
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /EC_number="2.1.1.354"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone-lysine N-methyltransferase NSD3; Wolf-Hirschhorn
                     syndrome candidate 1-like 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD3 isoform
                     2"
                     /protein_id="NP_001423721.1"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
                     /translation="MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDG
                     GPTPFEATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGA
                     VRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEI
                     KLKITKTIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEER
                     KSHKVPKLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQ
                     VGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRV
                     REYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREE
                     RVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQS
                     STDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVV
                     KIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSA
                     SPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQVETSPQASLKTGLQ
                     KGSADRGAQGSVRFSDLSVSAAKEETVD"
     misc_feature    1271..1660
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    1271..1660
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    order(1310..1312,1319..1321,1403..1405)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1310..1312,1319..1321,1403..1405)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    1313..1324
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    1313..1324
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1514..1522,1529..1534)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1514..1522,1529..1534)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     exon            1145..1216
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1379
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1534
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..2050
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2177
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2278
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2324
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..3923
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgggat gcagtcgcgc tgacgtcctc ctggttaccc acaagcctct gtaccccagt
       61 gcgggcagga agagggcaac cgggtccagt gcctgcccgg gaggacgggg tgccttctga
      121 gccggacgcg aactctgccc agtacccccc agtacttgta aactggcagc cacccgtctc
      181 tcactgcccc ggctcaggct ctcgtcctaa cgtactaccc ggtgtctggg acgcggaggc
      241 cagggcgctc tgctgacagc tgtcaggctg tcatcgactc ccaagcctcg gctctccccg
      301 gtctgcgtca ttgcgtaccg gtcattaggt tcttcctaac atctaggaat tgtagagcag
      361 ggccactcga ataccatatg gcgtctagta cgtgctgccg tttagctcga tgagagaaag
      421 ggaaagttaa ggatgctgga gcagaacaat ggatttctct ttctctttca tgcaagggat
      481 catgggaaac acaattcagc aaccacctca actcattgac tcggccaata tccgccagga
      541 ggatgccttt gataacaaca gtgacattgt tgaagatggt ggcccgacac ccttcgaagc
      601 tactttgcaa caaggtttcc aatgtccacc tgcaacagaa gaccttcctc cactcacaaa
      661 cggctaccca ccgtccatca gcttgtatga gactcaaacc aaatacccgc catatagcca
      721 gtatcccaat gggtcagcca acggttttgg tgcagttaga aactttagtc ctactgacta
      781 ttaccattca gaaattccaa acacaagacc acatgaaatt ctggaaaaac cgtctccccc
      841 acagcctcct cctcctcctc ttcttcctcc tcctcctcct ccggtaccac aaactgtgat
      901 tccaaagaag acaggctcac ccgagattaa actaaaaata accaaaacta tccagaatgg
      961 cagggaattg tttgagtcct ccctctgtgg agacctttta aacgaagtac aggccagtga
     1021 gcacttaaag tcaaagcacg aaagcagaaa ggaaaagagg aaaaaaagca gcagacacga
     1081 gtcatcgaga tccgaagagc gaaagtcaca caaggtcccc aagttagagc cagaggggca
     1141 gaatagacca aatgagaggg tggaccctgc accagaaaag ccaagagaag agccagtgct
     1201 caaagaggcc gtcccggttc agccaatact gtcttctgtt ccaacaacag aaacgtccac
     1261 tggtgttaag ttccaggttg gtgatcttgt ttggtccaag gtgggaacct atccttggtg
     1321 gccttgtatg gtttcaagtg atccccagct tgaggtccat accaaaatta acacaagagg
     1381 tgcccgggag tatcatgtcc agttttttag caaccagcca gagagggcat gggttcatga
     1441 gaagcgggta cgggagtata aaggtcacga acagtatgaa gagttactag cagaggcagc
     1501 caaacaagcc agcaaccatt ctgaaaagca aaagattcgg aaaccccgac ctcagagaga
     1561 acgcgcccag tgggatattg gcattgctca cgcagagaaa gcattgcaga tgacacgaga
     1621 ggaaagggta gaacagtaca cgttcatcta tatcgataag cagccagaag agtctccgtc
     1681 ccaagcaaag aagagtgtta cctctaaggc ggaagtcaag aaaccccgaa ggcccagatc
     1741 tgtggggaac agtcagccag aacagaccag tgctggggag gtggcttccc cacagtcgag
     1801 tactgaccct cgcaggcaga gccagaggcg gcacaccagt gtggaagagg acgggccgcc
     1861 tcccgttaaa atagcctgga gaacagccgc cgccaggaag tccttaccag cctccatcac
     1921 aatgcacaag gggagcctag atctgcacaa gtgtaatatg tctccagttg tgaaaattga
     1981 acaagtgttt gctctccaga atgcaacagg agatgggaag tttattgatc agtttgttta
     2041 ttcaacgaag ggaattggta acaaaacaga aataagtgtc agggggcaag acaggcttat
     2101 aatctcttca ccaagtcaga gaaacgagaa gtcgactccg agcgcgtcac ctccggaggc
     2161 cacatctggt tctgcaggcc cagtagaaaa gaagcagcag agaagatcaa tcaggactcg
     2221 atctgagtca gagaaatcca ccgaggttgt gtcaaagaag aagatcaaaa aggagcaggt
     2281 tgaaacatct cctcaggctt ccctgaagac cggattacag aaagggtcgg cggaccgagg
     2341 agcgcagggc tctgtccgat tcagtgacct ctccgtctcc gcagcgaaag aggaaactgt
     2401 ggactgagac tcctgtacaa tttcatccca gaaactccag acttggagtc tccgagcaag
     2461 aattctttgt cggcggctcg ataaagttcc ttttgttttg attttgattt tgccaatcat
     2521 cattattggc gctctctggc ctggtttctt cttcaagact gaacaattgc tttaacattc
     2581 agatgatttc tctctatctt tttttttttt ttttttttgt ccgagctgga tgggtacagc
     2641 ttaaatcatg ggtccagcct aaaaaaccac catttaactt accctgatcg attccaacat
     2701 ggactgtttt ggtttttgtt tttaaataaa gcatcattaa tacacatctg cagggttttg
     2761 ccaaatggcc caaactgtat acattgcaat cattaaaagc tcttattgtt tttttaacat
     2821 tagtgccgtt atcatggaga acaacaggac agccgccttc agcggtctgt catttttcta
     2881 gcattttcag aaactcatcg gaattggcgg gacccgtgtt tcccttcgca agcctctcag
     2941 tacagcactc ctgttcttct gttaaagctc cttgttaatt cagtgatctc ttaggccaag
     3001 gaagtacttt gtggtggtgt tctggtccca cacaccagca gtgaaagagt agatgtgtgt
     3061 acttgtgttt tctaatcagc actaacatgg gcaggcaccc tcattcgtag ctgtcaggca
     3121 gctctcagtg caaacttgta ggaaggggtg tgctaagaag gttccagtaa ccagagcagt
     3181 ctcgagaggc ccacatcctc ctccacagaa cgtggccgct aaacaccaag cgctcccatt
     3241 cagcctgttg cggatctaca tggccttagg agacttgttt ctccacggtc tcttctggac
     3301 tgcacacttc cgccatagct tgctgggctg agctagatgt ctgttcggaa agtttggggg
     3361 aagtctaaaa cagaccgtgg gtggagatct taccgtctcc ttggttcctt ggtattcacc
     3421 gtgcctgatc tgcacagttc atcgtggctg tctctgtata gcctaccgca ttagcccaag
     3481 agattgttgc tttgtaactt tttgcactat tgttttggct ggatttgtat tacacgcagt
     3541 tttaaaagaa aatttccaca ctcttctctg gcttcttttt ccatatatat atatatattt
     3601 cttctttccc tcacaaagtc cagaggcctc tcatctagtc cttggtgatt tattgcactt
     3661 ggaccctgat tgtccatcac agccctcagt gatgtgcctc ccacatggca tgacatgtgt
     3721 agatgtgccg cagcacttgt taacggtcac aataaatgcc actttaccaa gaaagaacaa
     3781 ttatgaaaat ccaaaatttt attgggggga taatcaaccg aattgcaaaa ttggggggtt
     3841 gaaatggcac tatccgtgta cgaatcgaat acaaatcaaa gatttgtcac atccctaata
     3901 aagcaagatg gagatgtctc tgc
//
LOCUS       NM_001436803            1466 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 9, mRNA.
ACCESSION   NM_001436803 XM_063287697
VERSION     NM_001436803.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 1466)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287697.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.22222.1,
                                           SRR26360194.1671406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000005.1  123105696-123105769
            75-175              JAXUCZ010000005.1  123106498-123106598
            176-200             JAXUCZ010000005.1  123118303-123118327
            201-346             JAXUCZ010000005.1  123122432-123122577
            347-508             JAXUCZ010000005.1  123130554-123130715
            509-641             JAXUCZ010000005.1  123131303-123131435
            642-706             JAXUCZ010000005.1  123132010-123132074
            707-779             JAXUCZ010000005.1  123134055-123134127
            780-931             JAXUCZ010000005.1  123138897-123139048
            932-1013            JAXUCZ010000005.1  123139751-123139832
            1014-1108           JAXUCZ010000005.1  123141269-123141363
            1109-1236           JAXUCZ010000005.1  123146672-123146799
            1237-1466           JAXUCZ010000005.1  123149294-123149523
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1466
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..74
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            75..175
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1300
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform h is encoded by transcript variant 9;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform h"
                     /protein_id="NP_001423732.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMM
                     EGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADN
                     DDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSE
                     IEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYL
                     PEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFN
                     VKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSER
                     YDFFAQQTRFGKKKYNLHPGVTMKRICPCCPQPLRAPLQGRD"
     misc_feature    710..859
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    710..859
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1028..1162
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1028..1162
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1028..1030,1118..1123,1127..1132,1136..1144,
                     1148..1156)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1028..1030,1118..1123,1127..1132,1136..1144,
                     1148..1156)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1190..>1249
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1190..>1249
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            176..200
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            201..346
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            347..508
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            509..641
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            642..706
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            707..779
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            780..931
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1013
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1108
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1236
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1466
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcggcct tcgcggtggc ggcggcggcg cgagtcttcg ctgcttccgc ggcgcgccgg
       61 gactacgctg cggaatggtg tggtggctcg attctcccag tgcctggctg agtttcggac
      121 gtggttaaga accaactggt tgaggttcaa tgcagacaag acggatgtga tgctgccatc
      181 tgttgagtct tcaagtccag ggggctcagc agcgtcagag gaccatgagt ttgatccgtc
      241 agctgacatg ctggttcatg attttgatga tgagcgaaca ttagaagaag aagaaatgat
      301 ggaaggagag acaaacttca gttctgaaat agaggatctt gcgagggaag gcgacatgcc
      361 aatcgacgag cttctcagcc tctatggtta tggcagcact gttcagttac ctgaagagga
      421 ggaggaggag gaagaagagg aggaagaagg tgaagatgat gaagatgcgg acaatgatga
      481 caacagtggc tgcagtgggg aaaataaaga agagaatata aaggattcat cgggtcagga
      541 ggatgaaact cagtcttcca atgatgatcc ctcacagtct gttacttccc aagatgctca
      601 ggaaataatc cgcccacgtc gatgtaaata ttttgataca aatagtgaaa tagaagaaga
      661 atctgaagaa gatgaagatt atattccctc agaagactgg aaaaaggaaa tcatggtagg
      721 ctccatgttt caagctgaga ttccagttgg cgtttgtaga tacaaagaaa atgaaaaagt
      781 gtatgaaaat gatgatcagc ttctgtggga tccagaatat ttaccagaag ataaagtgat
      841 tgtctttctt aaggatgcat ctagaagaac aggggatgag aaaggtgtag aagcaattcc
      901 tgaaggatct catataaaag acaatgaaca ggctttatat gaattggtta aatgcagttt
      961 tgatacagaa gaagccttga gaagactgag atttaatgtc aaagcagctc gagaggaatt
     1021 atctgtgtgg acagaggaag aatgtagaaa ttttgaacaa gggctgaagg cctatgggaa
     1081 agattttcat ctgattcagg ctaataaagt ccgaacaaga tcagttggtg aatgtgtagc
     1141 attctattac atgtggaaaa agtctgagcg ttatgatttc tttgctcagc aaacaaggtt
     1201 tggaaaaaag aaatataatc ttcatcctgg tgtaacaatg aagcgcattt gcccttgctg
     1261 cccacagcct ctgagagctc cactacaggg gagggattga gagccacatt cacattggag
     1321 agcttgctat tccgaataat acttaaaact ccagttacct gaactccagc gcttttaact
     1381 cctcaattgt tcgacccgac tttcttccta agcatttggg atttcattga taaaaataaa
     1441 gatgataatg gctatctgtc acagta
//
LOCUS       NM_001436775            3397 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 1, mRNA.
ACCESSION   NM_001436775 XM_017600035
VERSION     NM_001436775.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017600035.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.55452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-564             JAXUCZ010000016.1  19523772-19524029
            565-697             JAXUCZ010000016.1  19543122-19543254
            698-829             JAXUCZ010000016.1  19543358-19543489
            830-919             JAXUCZ010000016.1  19543675-19543764
            920-1060            JAXUCZ010000016.1  19544907-19545047
            1061-1228           JAXUCZ010000016.1  19545142-19545309
            1229-1508           JAXUCZ010000016.1  19546706-19546985
            1509-1810           JAXUCZ010000016.1  19548553-19548854
            1811-1885           JAXUCZ010000016.1  19549511-19549585
            1886-2078           JAXUCZ010000016.1  19549883-19550075
            2079-3397           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3397
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            307..564
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2209
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 1 is encoded by transcript variant 1; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 1"
                     /protein_id="NP_001423704.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQQIHNIRQHSSTGPPPLLLAPRASVP
                     SMQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVV
                     ASAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEV
                     VQNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKK
                     ALKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRK
                     LAFRSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTG
                     RHSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPR
                     SIPQSATWK"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    704..823
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1565..1666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1565..1666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            565..697
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            698..829
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1060
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1228
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1508
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1810
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1885
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2078
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..3397
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcgaatg agtgaagaag catgccgaac ccgcagtcag aagcgagcct ttgaacctga
      361 cctaacggag gatgatgtgg agagcaagaa aatgaaaatg gagagaggac catcagaact
      421 gccggtggat ggagacagca gggtgatgcc agagcccagt gcaggcccag cccaggggtt
      481 gctgaggaca acagaggcca tgggcacagg atctggcgaa gggctgttag gagacgggcc
      541 tgtggacatg cgtacctcac acagtgacat gaagtctgag aagagacctc cctcgcctga
      601 tgtgattgtg ctctctgaca gcgagcagcc atcaagcccg agggtgaatg gcctgaccac
      661 agtggccttg aaagacacca gcactgaggc gctcttgaaa agcagcccag aagagcgaga
      721 acggatgatc aagcagctga aggaggaatt gaggctagag gaagcaaagc tggtcttgtt
      781 gaagaagctg cgacagagtc aaatacagaa ggaagccact gcccagaagc ctacagcttc
      841 ctcagggagc actgtgacca cccctccccc actcgtgcgg ggtccccaga acattcctgc
      901 tggcaagcca tcactccaga cctcctccac tcggataccc ggcagcatca tcccaccacc
      961 actggtccga ggtgggcagc aggtgtctgc caaactggga ccacaggcca gctctcaagt
     1021 agtcatgcca ccacttgtca ggggagccca ggtgagtcag cagattcaca acatcagaca
     1081 gcattcctcc acggggccac cacccctcct cctggccccc cgtgcctcag tgcccagcat
     1141 gcagattcag ggacagagga tcatccagca gggactcatc cgggtcgcca atgtccccaa
     1201 caccagtctg ctcgtcaata tccctcagcc tacggcagcc tcactgaagg ggacaacagt
     1261 tggctctgct caggcaaact ccactcccag cagtgtggct tctgtggttg cctctgctga
     1321 gtccccagct agccggcagg ctgctgccaa gctagcgctg cgcaagcagt tggagaagac
     1381 actgctggag atccccccac ccaagccccc tgctccggag atgaacttct tgcccagtgc
     1441 tgccaacaat gaattcatct atctggtcgg cttggaggaa gtggtgcaga acctgctgga
     1501 gacgcaagcg ggcaggattt ctgccacctc agctgctgcc gtgttatccc gggagcctta
     1561 catgtgtgtg cagtgtaaga cagacttcac atgccgctgg cgagagaagg gtggagctgt
     1621 catgtgtgag aactgcatga catccaacca aaagaaggca ctaaaagtgg agcacaccag
     1681 tcgcctgaag gccgccttcg tgaaggcgct acaacaagag caggagatgg agcagcgact
     1741 gctgcagcag ggcgtaggca ccgccagcat caaggctgag accgcagctc cacatccctc
     1801 gctgaagcag gtcataaagc cccgacgtaa gttggcgttc cgctcaggag aggcccgtga
     1861 ctggaataac gggtccgtac tacagacttc cagccagctg tcccggggtt cagccacaac
     1921 acctcgtggt gttctgcaca ctttcagcca gtcacccaaa ctgcagaacg cagcctcagc
     1981 tacggccctg gtaagcagga ctggcagaca ttccgagaga gtcgtgggca ccagcaaggg
     2041 caccgcctcc aactggaaaa agacacctct gagcacaggt gggacgcttg ccttcgtcag
     2101 cccaagcttg gcagtgcaca agagctcctc ggccgtggac cgacagcgag agtacctcct
     2161 ggacatgatt cctccacgct ccatccccca gtcagccaca tggaaatagt gggagccggc
     2221 ccagccgagg acaggccctc tgctctcccg aggcccttgg tctaggacac gcagactacc
     2281 ctcctagcaa gttgcctgag acagctcagg ccttggctct tgccttgctg tggccaggag
     2341 agtaccacca tggtgcccag gatcagaacc agggaccttc cctatgggcc ttctccttcc
     2401 tttttgcctt tagtttgccc gacaccagca gaaactcgga ccttggggcc agctctgcct
     2461 ggccagcgtg ggtgggagct caccctggac actgtgacac acccgggcca gactggcacc
     2521 gggggctccc gaagttgagc cgggatttcg ttttcttttg gcttttccca tcttagctcc
     2581 ccagtctctg cctcttcatg gccatctata ggttgaagtt tgggttttat tgggtttttt
     2641 gtttttgttt tttttataat cacctcataa tgatgatgga attaaagtga actgcataga
     2701 cccagggtca tggttgtgca cagtgcagtc tggcaggctc taccccagag gatgctcaga
     2761 gtggcagcag cagagatggc aggtgccacc ctggctctgg tcgtgtttgt tgctgctcac
     2821 tgcagtccct ggcttccaca cttagcagaa tgaaccgcag cccagatctg tctgacatcc
     2881 agaggctcca gagggatgct ggggtccgcc atgctggagt cagagctgac tgctggctgg
     2941 gaggctgctg ggttactttt cgtggtttat tttattaaaa atttctatcc tttttctctt
     3001 cattttgatg gacacaatct caagatgccc atgcctgcca agaggcatcc aagtagggcc
     3061 cagccagaac ccttaggtct ggagtcagca gggcttactc cctcttagcc acagggatgt
     3121 ctgaaagggc tgagtctact tttgttctgt tttgtttcct tctccctcca ctcttaacaa
     3181 tgggttccat ggtgaaaggc agaagcagct ctgtgtccag cacgcacggt gcggccttct
     3241 gctcatgtga ttggtcgccg tcgtttcccc atccagccct ggtttccctt gacacaatac
     3301 agttagggac tttaatttaa acccttgttc tgcagaccat cgccctctgc agacatgccc
     3361 ctgcctcctc ctaataaagg ctcatttaac tccgtga
//
LOCUS       NM_001107926            4379 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 2
            (Lingo2), transcript variant 2, mRNA.
ACCESSION   NM_001107926 XM_001057633 XM_001057690 XR_006940
VERSION     NM_001107926.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4379)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   2  (bases 1 to 4379)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107926.1.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000005.1  55310716-55310907   c
            193-299             JAXUCZ010000005.1  55230368-55230474   c
            300-4379            JAXUCZ010000005.1  55166250-55170329   c
FEATURES             Location/Qualifiers
     source          1..4379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21-q22"
     gene            1..4379
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine rich repeat and Ig domain containing 2"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
     exon            1..192
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            193..299
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            300..4379
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="upstream in-frame stop codon"
     CDS             335..2155
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2
                     precursor"
                     /protein_id="NP_001101396.1"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
                     /translation="MLHTAIPCWQPFLGLAMVLLFMGSTIGCPARCECSAQNKSVSCH
                     RRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFN
                     NLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV
                     GDNDLVYISHRAFSGLFSLEQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNINNMPV
                     YAFKRLFHLKQLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLT
                     HLNLSYNPISTIEAGMFSDLIRLQELHVVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE
                     TLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQATLQFGGQQPMCAGPDTIRERS
                     FKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRR
                     FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRF
                     LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVW
                     SRGKGKHKNSIDLEYVPRKNNGAVAEGEVAGPRRFNMKMI"
     sig_peptide     335..415
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    413..514
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    413..514
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    449..505
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    449..505
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    476..>1354
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    476..>1354
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    509..580
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    509..580
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    581..652
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    581..652
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    653..724
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    653..724
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..796
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    725..796
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    797..868
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    797..868
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    869..940
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    869..940
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    941..1084
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    941..1084
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1085..1156
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1085..1156
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1157..1228
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1157..1228
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1229..1300
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1229..1300
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1301..1363
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1301..1363
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1313..>1507
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1313..>1507
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1565..1834
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1565..1834
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1616..1630
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1616..1630
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1655..1669
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1655..1669
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1730..1744
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1730..1744
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1772..1789
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1772..1789
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1811..1822
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1811..1822
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
ORIGIN      
        1 agggcactct agaaacccag cctgcatgta gacagccctg cctactgcag aagatgattc
       61 ctgccccggg ttaaacgtgt acaactcgtg gaaatgccag taccttccac ctgaaggcac
      121 ttagtggcta gaaaaccagc aatctacccc gaaacacact gtactaaaca cagcaagaga
      181 ccacaatgat tggacataga cctataagga tacactttga gaaagatgcc agttgttcct
      241 caggatgcac tttgaaaatg cagtcattct agctggtacc gcaaaatgag tgcattaagg
      301 cccataacca aggtgtagaa taaacagtgg agtcatgctt cacacggcta taccatgctg
      361 gcagccattc ctgggtctgg ctatggtgtt actcttcatg ggatccacca ttggctgtcc
      421 tgctcgctgt gagtgctctg cccagaacaa atctgttagc tgccacagaa gacgcttgat
      481 cgcgatcccc gaaggcattc ccattgagac caaaatcttg gacctgagca aaaatcgact
      541 aaagagcata aaccccgaag aattcatctc atatcctctg ttggaggaga tagacttgag
      601 cgacaacatc atcgccaatg tagaacctgg ggcatttaac aatctcttta acctgcgttc
      661 cctccgccta aaaggcaatc gccttaagtt ggtccctttg ggagtattca cgggactgtc
      721 caacctcacc aagcttgaca ttagtgagaa taagattgtc attttgctgg actacatgtt
      781 ccaggatctg cataacctga agtctctaga agtgggggac aatgatttgg tttatatatc
      841 acacagggcc ttcagtggac tatttagctt ggagcagctc accctggaga agtgcaactt
      901 gacagcggta ccaacagaag ccctttccca tctccgcagc ctcatcaccc tgcatctgaa
      961 gcatctcaat atcaacaata tgcctgtgta tgcctttaaa agattattcc acctgaaaca
     1021 actagagatc gactattggc cattgctgga tatgatgcca gccaatagcc tctatggtct
     1081 caacctcaca tccctctcga tcactaacac caacctgtcc actgtccctt tcctcgcctt
     1141 taaacacctt gtatacctga cccaccttaa cctctcctac aatcccatca gcactattga
     1201 agcaggcatg ttctctgacc tgatccgcct acaggagctt catgtagtcg gggcccagct
     1261 ccgcaccatt gaacctcact ccttccaagg gctccgcttc ctccgcgtgc tcaatgtatc
     1321 tcagaacctg ctggaaacat tggaagagaa tgtcttctct tcccctaggg ctttggaggt
     1381 cctgagcatt aacaataacc cactagcgtg cgactgccga cttctctggc tcctgcagcg
     1441 acaggccacc ctgcagtttg gaggccagca gcccatgtgt gccgggccag acaccatacg
     1501 tgagaggtca tttaaggatt tccatagcac tgctctttct ttttatttta cctgcaaaaa
     1561 acccaaaatc cgtgaaaaga agttacagca cctcctagtg gacgaaggac agacggtcca
     1621 gctggagtgc aacgcggatg gagaccccca gcccgtgatt tcctgggtga cacctcgaag
     1681 gcgttttatc accaccaagt ccaacggaag ggccactgtg ttgggtgatg gcaccttaga
     1741 aatccgtttc gcccaggatc aagacagtgg gatgtatgtt tgcatagcta gcaatgctgc
     1801 tgggaatgac accttcacgg catctctcac tgtgaaggga ttcacttcag accgcttcct
     1861 ttacgcaaac aggaccccta tgtacatgac tgactccaat gacaccgttt ccaacggcac
     1921 taatgccaat actttttccc tggaccttaa aacaatactg gtatctacag ccatgggctg
     1981 tttcacattc ctgggagtgg ttttattttg ttttctcctt ctttttgtgt ggagccgagg
     2041 aaagggcaaa cacaaaaaca gcattgacct tgagtatgtg ccccgaaaaa acaatggtgc
     2101 tgttgcagaa ggggaggtgg ctggacccag gaggttcaac atgaaaatga tataagggcc
     2161 caccacacac acactactac tgtctctgtg ttactgttgg taatgagtaa gacgtctgat
     2221 atagcgagtc catcacaagg tgatcaggca gcttcacaca gctgcccctg tgtcaaagca
     2281 gggtccatgg aagctggaag acttctcatg gacactggct gattagaggc aggcaggcat
     2341 gtgtcagagc ccttcacaca gtgggatact aattgtttgc attgcaaata ttggcattct
     2401 ggggatctca gtaatgaccc tgaacctttg gctcatgctg acggacaaaa attcaacatt
     2461 ttctaccact gcaaaactaa aagaaaaaaa atttaaaagg aacaacctac agtgtaggat
     2521 ttacatatta aaaaaagaca catttgtcta aaacatactc tacggtaaaa tttgtattta
     2581 ttatcatttg ttaaaacctt gcatcataca atactgttgg ttcagcacca aaaaaaaaaa
     2641 aaaaaaaaaa aagagagatc aatatattct tttttgaaac atatatgctg tatatgtttt
     2701 aaagcaatat gaatgagagg ttgtgctttt agttactcac cagtatagat ccaagtgtgg
     2761 tctcactttc cttttatccg cagagaaacc tgagaataga tccctggaat aataggctga
     2821 gatgtgttga gatgtgtatg tctgatgtag gatgccaaga tacaagagcc cagtcaaaac
     2881 tgctcaactc tgttaacttc tgttactata aataaaggca tgtgcctagt tttgatacag
     2941 aatggaatat tttttatatg tacactacca acctggacca gtttactgta acagaagccc
     3001 ttggtttctc cagaaggtgg tacgtctcta gatgtgcctg tagaatgcaa ggtaggtgcc
     3061 actcataaaa gtgatccatt tagctactgc ttagttttac ttttgccagt cactgctaag
     3121 gggttaatga ccaatggaaa agagaatatt gatcatatag atttggcaat agtcgccaat
     3181 gtctaatgtc aataattctg ttacccaaaa gctctctgga taaagaggtt tcagaagtca
     3241 ataggaagca gggtgagaca agtgcgtcac agtagtgatc ctgccaatga tccttttcaa
     3301 atgtgacagc tgctgacaga cggctacaga tcaaagggaa cacatagcac atgacatccc
     3361 aattctatcc aatacacagt agggccacga ttaggcaact tcaggatatt tccctgcttc
     3421 ctgatcaaga tttttagctt catattggaa actatattac atagataaga ggaatttgtt
     3481 ttgtgtgaag tagcaaaaga aaaaccatta tagatctaaa aagcaatgtt ttgttccttc
     3541 actggggaag agttaagcct atagttctac aaatatgtaa tgctatgctg cttcttttac
     3601 cttcctgacc tgagcatatt tacccagtta agcagttaat gtcaccactc caaaacaaac
     3661 aaacaaaaaa aaaaacagaa aaaaaggaaa aaaggaaaga aagatagaaa atagcattat
     3721 tatcataagt gacctggtta aaggaagcat aatttcattt ggctcagtcc tggataactt
     3781 tcaaagcaca tatccatatg gccagaaaaa tattggatgc agactatatt cttgaagtga
     3841 catgtatgta atcaatataa agaaagtctc tatacttttc acattttgag aggatcttga
     3901 ggaaggtctt ctttaggtta tattgtaaga tatgtacaag gattctggga tttcttcctt
     3961 ttagtattgt gggtctgacc ctcaaaagcc tagctttgtt aaatatttga aaatatgaag
     4021 aactttaata ctattaaatt ggcctttatt tctaaaattt ttcatagact cttttgcaaa
     4081 ttgagtgtca atacttctaa acccatttat cctttgccag tgggtaggaa ctgagttgta
     4141 gatttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtaag attgaatagt tgcctgcttt
     4201 gagttagatt ttattcaatt atcatgacga ttatcacaaa tgttttacaa atttaattta
     4261 catttaaaga ctaattcatt tctagtaatt tgtatcaacc tcaactaaac tctatcaaaa
     4321 tttcaactct tgaaaaatta aatgctttct tcttacaata aagaaagtta aagtggaaa
//
LOCUS       NM_001436782            3330 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 9, mRNA.
ACCESSION   NM_001436782 XM_063275198
VERSION     NM_001436782.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3330)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3330)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3330)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3074312.1,
                                           SRR26360181.594807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000016.1  19500545-19500690
            147-248             JAXUCZ010000016.1  19508790-19508891
            249-506             JAXUCZ010000016.1  19523772-19524029
            507-639             JAXUCZ010000016.1  19543122-19543254
            640-771             JAXUCZ010000016.1  19543358-19543489
            772-861             JAXUCZ010000016.1  19543675-19543764
            862-993             JAXUCZ010000016.1  19544907-19545038
            994-1161            JAXUCZ010000016.1  19545142-19545309
            1162-1441           JAXUCZ010000016.1  19546706-19546985
            1442-1743           JAXUCZ010000016.1  19548553-19548854
            1744-1818           JAXUCZ010000016.1  19549511-19549585
            1819-2011           JAXUCZ010000016.1  19549883-19550075
            2012-3330           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3330
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..146
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            249..506
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2142
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 3 is encoded by transcript variant 9; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 3"
                     /protein_id="NP_001423711.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQQIHNIRQHSSTGPPPLLLAPRASVPSMQ
                     IQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASA
                     ESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQN
                     LLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALK
                     VEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAF
                     RSGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHS
                     ERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIP
                     QSATWK"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1498..1599
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1498..1599
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            507..639
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            640..771
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            772..861
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            862..993
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1161
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1441
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1743
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1818
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2011
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..3330
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgttcctt tagctcccgt aggagcagaa cctagatacg cttcctccag cttggtgggg
       61 tgaccctcct caagcccctg aaaacaccag gaaatattgg ggagagtctt aggtcttcca
      121 actgccctgc ttaggggggg tcacaggttg gccagcacat tgagccagca catccacata
      181 agttgccttt tgacagagct gtggccatga cggcatggta ggaccagcgt cacggaccct
      241 gaggccagaa tgagtgaaga agcatgccga acccgcagtc agaagcgagc ctttgaacct
      301 gacctaacgg aggatgatgt ggagagcaag aaaatgaaaa tggagagagg accatcagaa
      361 ctgccggtgg atggagacag cagggtgatg ccagagccca gtgcaggccc agcccagggg
      421 ttgctgagga caacagaggc catgggcaca ggatctggcg aagggctgtt aggagacggg
      481 cctgtggaca tgcgtacctc acacagtgac atgaagtctg agaagagacc tccctcgcct
      541 gatgtgattg tgctctctga cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc
      601 acagtggcct tgaaagacac cagcactgag gcgctcttga aaagcagccc agaagagcga
      661 gaacggatga tcaagcagct gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg
      721 ttgaagaagc tgcgacagag tcaaatacag aaggaagcca ctgcccagaa gcctacagct
      781 tcctcaggga gcactgtgac cacccctccc ccactcgtgc ggggtcccca gaacattcct
      841 gctggcaagc catcactcca gacctcctcc actcggatac ccggcagcat catcccacca
      901 ccactggtcc gaggtgggca gcaggtgtct gccaaactgg gaccacaggc cagctctcaa
      961 gtagtcatgc caccacttgt caggggagcc cagcagattc acaacatcag acagcattcc
     1021 tccacggggc caccacccct cctcctggcc ccccgtgcct cagtgcccag catgcagatt
     1081 cagggacaga ggatcatcca gcagggactc atccgggtcg ccaatgtccc caacaccagt
     1141 ctgctcgtca atatccctca gcctacggca gcctcactga aggggacaac agttggctct
     1201 gctcaggcaa actccactcc cagcagtgtg gcttctgtgg ttgcctctgc tgagtcccca
     1261 gctagccggc aggctgctgc caagctagcg ctgcgcaagc agttggagaa gacactgctg
     1321 gagatccccc cacccaagcc ccctgctccg gagatgaact tcttgcccag tgctgccaac
     1381 aatgaattca tctatctggt cggcttggag gaagtggtgc agaacctgct ggagacgcaa
     1441 gcgggcagga tttctgccac ctcagctgct gccgtgttat cccgggagcc ttacatgtgt
     1501 gtgcagtgta agacagactt cacatgccgc tggcgagaga agggtggagc tgtcatgtgt
     1561 gagaactgca tgacatccaa ccaaaagaag gcactaaaag tggagcacac cagtcgcctg
     1621 aaggccgcct tcgtgaaggc gctacaacaa gagcaggaga tggagcagcg actgctgcag
     1681 cagggcgtag gcaccgccag catcaaggct gagaccgcag ctccacatcc ctcgctgaag
     1741 caggtcataa agccccgacg taagttggcg ttccgctcag gagaggcccg tgactggaat
     1801 aacgggtccg tactacagac ttccagccag ctgtcccggg gttcagccac aacacctcgt
     1861 ggtgttctgc acactttcag ccagtcaccc aaactgcaga acgcagcctc agctacggcc
     1921 ctggtaagca ggactggcag acattccgag agagtcgtgg gcaccagcaa gggcaccgcc
     1981 tccaactgga aaaagacacc tctgagcaca ggtgggacgc ttgccttcgt cagcccaagc
     2041 ttggcagtgc acaagagctc ctcggccgtg gaccgacagc gagagtacct cctggacatg
     2101 attcctccac gctccatccc ccagtcagcc acatggaaat agtgggagcc ggcccagccg
     2161 aggacaggcc ctctgctctc ccgaggccct tggtctagga cacgcagact accctcctag
     2221 caagttgcct gagacagctc aggccttggc tcttgccttg ctgtggccag gagagtacca
     2281 ccatggtgcc caggatcaga accagggacc ttccctatgg gccttctcct tcctttttgc
     2341 ctttagtttg cccgacacca gcagaaactc ggaccttggg gccagctctg cctggccagc
     2401 gtgggtggga gctcaccctg gacactgtga cacacccggg ccagactggc accgggggct
     2461 cccgaagttg agccgggatt tcgttttctt ttggcttttc ccatcttagc tccccagtct
     2521 ctgcctcttc atggccatct ataggttgaa gtttgggttt tattgggttt tttgtttttg
     2581 ttttttttat aatcacctca taatgatgat ggaattaaag tgaactgcat agacccaggg
     2641 tcatggttgt gcacagtgca gtctggcagg ctctacccca gaggatgctc agagtggcag
     2701 cagcagagat ggcaggtgcc accctggctc tggtcgtgtt tgttgctgct cactgcagtc
     2761 cctggcttcc acacttagca gaatgaaccg cagcccagat ctgtctgaca tccagaggct
     2821 ccagagggat gctggggtcc gccatgctgg agtcagagct gactgctggc tgggaggctg
     2881 ctgggttact tttcgtggtt tattttatta aaaatttcta tcctttttct cttcattttg
     2941 atggacacaa tctcaagatg cccatgcctg ccaagaggca tccaagtagg gcccagccag
     3001 aacccttagg tctggagtca gcagggctta ctccctctta gccacaggga tgtctgaaag
     3061 ggctgagtct acttttgttc tgttttgttt ccttctccct ccactcttaa caatgggttc
     3121 catggtgaaa ggcagaagca gctctgtgtc cagcacgcac ggtgcggcct tctgctcatg
     3181 tgattggtcg ccgtcgtttc cccatccagc cctggtttcc cttgacacaa tacagttagg
     3241 gactttaatt taaacccttg ttctgcagac catcgccctc tgcagacatg cccctgcctc
     3301 ctcctaataa aggctcattt aactccgtga
//
LOCUS       NM_001107929            4263 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus ring finger protein 20 (Rnf20), transcript
            variant 2, mRNA.
ACCESSION   NM_001107929 XM_001053340 XM_001053415 XM_001053479 XM_001053543
            XM_001053616 XM_232995
VERSION     NM_001107929.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4263)
  AUTHORS   Lai,C.Y., Hsieh,M.C., Ho,Y.C., Wang,H.H., Chou,D., Wen,Y.C.,
            Yang,P.S., Cheng,J.K. and Peng,H.Y.
  TITLE     Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates
            mGluR5 Transcription for Neuropathic Allodynia
  JOURNAL   J Neurosci 38 (43), 9160-9174 (2018)
   PUBMED   30201771
  REMARK    GeneRIF: RNF20-drive H2B monoubiquitination, which facilitates
            phosphorylated mGluR5 transcription in the dorsal horn in the
            development of neuropathic allodynia.
REFERENCE   2  (bases 1 to 4263)
  AUTHORS   Stracker,T.H., Roig,I., Knobel,P.A. and Marjanovic,M.
  TITLE     The ATM signaling network in development and disease
  JOURNAL   Front Genet 4, 37 (2013)
   PUBMED   23532176
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4263)
  AUTHORS   Wang,E., Kawaoka,S., Yu,M., Shi,J., Ni,T., Yang,W., Zhu,J.,
            Roeder,R.G. and Vakoc,C.R.
  TITLE     Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3901-3906 (2013)
   PUBMED   23412334
REFERENCE   4  (bases 1 to 4263)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   5  (bases 1 to 4263)
  AUTHORS   Liu,Z., Oh,S.M., Okada,M., Liu,X., Cheng,D., Peng,J., Brat,D.J.,
            Sun,S.Y., Zhou,W., Gu,W. and Ye,K.
  TITLE     Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor
  JOURNAL   Mol Biol Cell 20 (3), 757-768 (2009)
   PUBMED   19037095
REFERENCE   6  (bases 1 to 4263)
  AUTHORS   Shema,E., Tirosh,I., Aylon,Y., Huang,J., Ye,C., Moskovits,N.,
            Raver-Shapira,N., Minsky,N., Pirngruber,J., Tarcic,G.,
            Hublarova,P., Moyal,L., Gana-Weisz,M., Shiloh,Y., Yarden,Y.,
            Johnsen,S.A., Vojtesek,B., Berger,S.L. and Oren,M.
  TITLE     The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a
            putative tumor suppressor through selective regulation of gene
            expression
  JOURNAL   Genes Dev 22 (19), 2664-2676 (2008)
   PUBMED   18832071
  REMARK    Erratum:[Genes Dev. 2017 Sep 15;31(18):1926. doi:
            10.1101/gad.307207.117. PMID: 29051390]
REFERENCE   7  (bases 1 to 4263)
  AUTHORS   Tan,L.B., Chen,K.T., Tyan,Y.C., Liao,P.C. and Guo,H.R.
  TITLE     Proteomic analysis for human urinary proteins associated with
            arsenic intoxication
  JOURNAL   Proteomics Clin Appl 2 (7-8), 1087-1098 (2008)
   PUBMED   21136906
REFERENCE   8  (bases 1 to 4263)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   9  (bases 1 to 4263)
  AUTHORS   Kim,J., Hake,S.B. and Roeder,R.G.
  TITLE     The human homolog of yeast BRE1 functions as a transcriptional
            coactivator through direct activator interactions
  JOURNAL   Mol Cell 20 (5), 759-770 (2005)
   PUBMED   16337599
REFERENCE   10 (bases 1 to 4263)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107929.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643292.21664.1, SRR26643289.15248.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               JAXUCZ010000005.1  68771586-68772008
            424-579             JAXUCZ010000005.1  68772781-68772936
            580-747             JAXUCZ010000005.1  68777806-68777973
            748-895             JAXUCZ010000005.1  68778083-68778230
            896-1078            JAXUCZ010000005.1  68778519-68778701
            1079-1197           JAXUCZ010000005.1  68781319-68781437
            1198-1344           JAXUCZ010000005.1  68783751-68783897
            1345-1422           JAXUCZ010000005.1  68784871-68784948
            1423-1542           JAXUCZ010000005.1  68785120-68785239
            1543-1722           JAXUCZ010000005.1  68788897-68789076
            1723-1858           JAXUCZ010000005.1  68790139-68790274
            1859-1980           JAXUCZ010000005.1  68790590-68790711
            1981-2345           JAXUCZ010000005.1  68790829-68791193
            2346-2463           JAXUCZ010000005.1  68792266-68792383
            2464-2613           JAXUCZ010000005.1  68793353-68793502
            2614-2826           JAXUCZ010000005.1  68793892-68794104
            2827-2952           JAXUCZ010000005.1  68794789-68794914
            2953-3093           JAXUCZ010000005.1  68795036-68795176
            3094-3195           JAXUCZ010000005.1  68795789-68795890
            3196-4263           JAXUCZ010000005.1  68796173-68797240
FEATURES             Location/Qualifiers
     source          1..4263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4263
                     /gene="Rnf20"
                     /note="ring finger protein 20"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
     exon            1..423
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            424..579
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    430..432
                     /gene="Rnf20"
                     /note="upstream in-frame stop codon"
     CDS             451..3372
                     /gene="Rnf20"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 20, E3 ubiquitin protein
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1A"
                     /protein_id="NP_001101399.2"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
                     /translation="MSGIGNKRAAGEPGTSVPPEKKTAVEDSGTTVETIKLGGVSSTE
                     ELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE
                     NIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLA
                     TLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIMEEAV
                     QELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQW
                     DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE
                     NKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLY
                     NESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRK
                     EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL
                     NKTRLRSGSALLQSQSSTEDAKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEE
                     RERERREKEREREREREKEKEREREKQKLKESEKERDPVKDKDKGKHDDGRKKEAEII
                     KQLKTELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDL
                     EDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAVAKQEEEALLSEMDVTGQAFEDM
                     QEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQ
                     VVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKL
                     HDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDY
                     KARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI
                     G"
     misc_feature    <1408..3252
                     /gene="Rnf20"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <1408..3252
                     /gene="Rnf20"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    3148..3369
                     /gene="Rnf20"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 20 (RNF20); Region: RING-HC_RNF20; cd16814"
                     /db_xref="CDD:438463"
     misc_feature    3148..3369
                     /gene="Rnf20"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 20 (RNF20); Region: RING-HC_RNF20; cd16814"
                     /db_xref="CDD:438463"
     exon            580..747
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            748..895
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1078
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1197
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1344
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1422
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1542
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1722
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1858
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1980
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2345
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2463
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2613
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2826
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2952
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3093
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3195
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..4263
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccctgc ctccgcctcc gtgaagctca atccctcttg gagcaggtcc gaaatgaggg
       61 attgaatccc gcaccgccct tcgtaaataa cccctggaag ctgcgcgccc gcggcgggag
      121 ttgctagagc ccaggtttgc tctgttgtcc ggtgctcctg ggccctgagt ggcgaggtcc
      181 catcttcccg gcctgtggct tgccacgccg gaggttgcgg ccagcgcttt ccattcaagt
      241 tgcgctccct cctcatctct tgtttcctct ctttccaggc gagatccaac tcagattgct
      301 gcttgccata ggttccttgt cctggagttt gaattggaag ccggcggggt gtagactcgt
      361 gatggtcgcg tttctcgcga tctagcatcc attcctcctc ctttaagcat cggaaccagt
      421 cagaaaaaat agctgtcatc ttataccaag atgtcaggga ttggaaataa aagagcggct
      481 ggagagccag gcacatctgt gcccccagag aagaagacag ctgtcgaaga ttcagggacc
      541 acagtggaaa caattaaact aggaggtgtc tcttcaacgg aggaattaga cattcgaaca
      601 ctgcaatcga aaaatcgtaa gctagcagaa atgctagatc agcggcaggc cattgaagat
      661 gagcttcggg agcacattga gaagctggag cgacgccagg ccaccgacga tgcctcactg
      721 ttgatcgtga accggtactg gagccagttt gatgaaaaca tccgcatcat ccttaaacgt
      781 tatgatctgg accagggttt gggagaccta ctcacagaaa ggaaagcctt ggttgtgcca
      841 gagcctgagc ccgactctga cagtaatcag gagcgcaaag atgaccgtga gagaggggaa
      901 gggcaagagc cagctttctc tttccttgct actttggcta gcagttccag tgaggagatg
      961 gagtcccagc ttcaggagcg cgtggagtcc tcccgccgtg ctgtgtctca gattgtgacc
     1021 gtctatgata aattgcaaga aaaagtggat ctcttgtccc ggaaactgaa cagtggagat
     1081 aacctgataa tggaggaagc agtacaggag ctgaactcct tccttgcgca agagaatgtg
     1141 aggctccagg aactgacaga tctccttcag gagaagcatc acaccatgtc tcaggagttc
     1201 tgtaagctgc agggtaaagt agagacagca gagtcacgag tgtccgtctt ggagtccatg
     1261 attgatgacc tgcagtggga tattgacaaa attcgaaaaa gagaacagcg gctcaaccgg
     1321 catttggctg aagtcctaga gcgggtgaac tcaaaaggct ataaagtgta cggagcaggg
     1381 agcagtctct atggaggcac aatcaccatc aatgcccgga agtttgagga aatgaatgct
     1441 gagcttgagg agaacaaaga gttggctcag aaccgacatt gtgagctaga gaaacttcgt
     1501 caagactttg aagaggtcac tacacagaat gaaaagttga aggtggagtt gcggagcgca
     1561 gtggaggaag tggttaagga aaccccagaa tatcgctgca tgcagtcaca gttctctgtc
     1621 ctgtacaatg agagtctaca gttgaaagct cacttggatg aagctcggac cctgcttcat
     1681 ggcacccggg gaactcacca gcgccaggtt gaactcattg agcgagatga ggttagtctg
     1741 cataagaagc tgagaactga agtgattcag ctggaggata ccttggccca ggtccgcaag
     1801 gagtatgaga tgttgaggat agagtttgag cagacccttg cggccaatga acaagcaggc
     1861 cccataaacc gggagatgcg gcacctcatt agcagtctcc agaaccataa ccaccagctg
     1921 aagggggagg tcctgaggta taagcggaaa ctcagagagg cacagtctga cctgaacaag
     1981 acgcgtctgc gcagtggcag tgccctcctg cagtcgcagt ctagtactga ggacgccaag
     2041 gatgaaccca cagagctgaa gcaagactct gaggacctcg ccactcattc ctcagcattg
     2101 aaggcctctc aggaggatga agtgaagtct aagcgggatg aggaagagag agaacgagaa
     2161 aggagggaga aagaaagaga gagagaacga gaacgggaaa aggaaaagga gagagaacga
     2221 gagaaacaga aactgaaaga gtcggaaaaa gagagagatc ctgttaagga taaggacaaa
     2281 gggaagcacg atgacgggag gaagaaggag gcagagatca tcaagcagct gaagactgag
     2341 ctcaagaaag cacaagagag ccagaaggag atgaagctgc tcctggacat gtaccgctct
     2401 gcccccaagg agcagagaga caaagtgcag ctaatggcgg ccgagaagaa gtcaaaggca
     2461 gagttggagg atctcaggca aagactcaag gatctggaag ataaggagaa gaaggagaat
     2521 aagaaaatgg ctgatgagga cgccttgagg aagatccggg cagtggaaga gcagatcgaa
     2581 tacctgcaga agaagctggc tgtggccaag caggaggaag aagctctcct gtctgagatg
     2641 gatgtcacag gacaggcctt tgaggacatg caggagcaga acatccgttt gatgcagcag
     2701 ttgcgggaga aggatgatgc aaacttcaag ctcatgtcag agcggatcaa gtctaatcag
     2761 atccataagt tgcttaaaga ggaaaaggaa gagttagctg accaggtttt gacactgaag
     2821 actcaggtag atgcccagtt acaggtagta agaaagctgg aagagaagga gcacctgctt
     2881 cagagtaaca ttggcacagg ggagaaggag ctgggtctta ggactcaagc cttagagatg
     2941 aataaacgca aggccatgga ggcggcccag cttgcagatg acctcaaagc acagctggaa
     3001 ctggctcaga agaagctcca tgattttcag gatgaaattg tggagaacag tgtcaccaag
     3061 gaaaaggact tgttcaattt caaacgcgca caggaagaca tctctaggct ccgaagaaag
     3121 ctggagacaa ccaagaagcc agacaacgtg cccaaatgtg acgagattct gatggaggag
     3181 ataaaggact acaaggcgcg gctgacctgc ccttgctgta acatgcgtaa aaaggatgca
     3241 gtacttacca agtgttttca cgttttctgc tttgagtgtg tgaagacgcg ctatgacact
     3301 cgccagcgca agtgtcccaa gtgtaacgct gctttcggtg ccaatgattt ccatcgcatc
     3361 tacattggct gagtgcagtc aagagagaga actggctagg caagcactta ctcatcagtc
     3421 accaggcctc tacctctccc tctgtgacag ctggccggct ccctgctccc cggactgtcc
     3481 aggttctctt cgccagtagc cagagaacat tcgtgaaaaa gactgcaagt cttggggttt
     3541 agaatgaact agaagctact agtgtttgtc ttcctatcag ctttctttat gtcctttcag
     3601 agttttcagc attttcttct tgggcaaagc ctgtaaactt ggatttaccc atcctcctga
     3661 agaagtcagg ttgatggttt tgacactgag aagggaatgt catagagtga acatatacta
     3721 ttatggagta gtgaactttt agaaataagc tatcgatggg ccccaaattc ttgatttggt
     3781 aataaacctt tctaaactta ggttgtaaaa tggtataatt gtgatagtct ctcctggaag
     3841 gttcgaagcc ttaatgaaat tatatccagg ataagtctat ctctcatttc tagtaaactg
     3901 actttttggg tcagttggac ttcttgctaa agttatttat gttttaagta ttcaaatatt
     3961 aataggtttt tttttttaat ttcttaaggc cagaatgatt tcaaacatga tagttcctat
     4021 ggttttgctt tttgtttttt tcctcctgaa atcagactta gtacttaaga agcagcagga
     4081 atggattatg aagagatcta ggtagtctag gataagatcc agagagggtt ggtgaattat
     4141 gaattactgt catcatcctc tcagagggac tctttgattt ctgttttcca gaagattctc
     4201 agtaatgttt ctgtaggatt ttaatattcc atatactttc aattaaagca ggattcagct
     4261 ttc
//
LOCUS       NM_001436818            9393 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus storkhead box 2 (Stox2), transcript variant 4,
            mRNA.
ACCESSION   NM_001436818
VERSION     NM_001436818.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9393)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 9393)
  AUTHORS   Fenstad,M.H., Johnson,M.P., Loset,M., Mundal,S.B., Roten,L.T.,
            Eide,I.P., Bjorge,L., Sande,R.K., Johansson,A.K., Dyer,T.D.,
            Forsmo,S., Blangero,J., Moses,E.K. and Austgulen,R.
  TITLE     STOX2 but not STOX1 is differentially expressed in decidua from
            pre-eclamptic women: data from the Second Nord-Trondelag Health
            Study
  JOURNAL   Mol Hum Reprod 16 (12), 960-968 (2010)
   PUBMED   20643876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3091468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               JAXUCZ010000016.1  51779138-51779660
            524-676             JAXUCZ010000016.1  51796410-51796562
            677-2942            JAXUCZ010000016.1  51806139-51808404
            2943-9393           JAXUCZ010000016.1  51813459-51819909
FEATURES             Location/Qualifiers
     source          1..9393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..9393
                     /gene="Stox2"
                     /note="storkhead box 2"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
     exon            1..523
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    508..510
                     /gene="Stox2"
                     /note="upstream in-frame stop codon"
     exon            524..676
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..3138
                     /gene="Stox2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     knockout CG10573-PA related; storkhead-box protein 2;
                     spinelinin"
                     /codon_start=1
                     /product="storkhead-box protein 2 isoform 4"
                     /protein_id="NP_001423747.1"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
                     /translation="MSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLTTCFP
                     GVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHLDERV
                     PDRSQCTSPQPGTITPSASGCVRERTLPRKHCDSCHCCREDMHSMHASTLQRKPAKDC
                     KDPYCPPPLCQVPPTDKSKSTINFSYKTETLSKPKDGEKQSKKFGLKLFRLSFKKDKT
                     KQLANFSAQFPPEEWPLRDEDTPTTIPREVEMEIIRRINPDLTVENVMRHTALMKKLE
                     EEKAHRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIPGERE
                     YEFCDPLTRAPREGCFIIEHKGDNFIMHSNTNVIESHFPMTPEWDVSGELAKRRTEMP
                     FPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGTPEDL
                     AEGCSQDDQTASQSYIDDSTLRPAQTIGHQRAHIPSASYKEVCIPEIVGGSKEPSSAC
                     SLLEPGKSPESMPSYGELSPCPAKTAVDDYFQCNTSSETVLTAPSPLGKNKEDHDTLT
                     LVEGVKKLSPSERQTPHSSRDPVGHKEESPKGPGGGPAASGGVAEGLANGRLVQHHSA
                     EPSNLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKSPADTLPGRCEKMEP
                     SLGTSAAQAMPPSQRQQEPGGNQEASFDYYNVSDDDDSEEGANKNTEEEKNRDDVGTM
                     QWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDSMDSSSITVDSGFNS
                     PRTRESLASNTSSIVESNRRQNPALSPAHGGAGPTFNFRASTDPPTSEAEKLQKPSNC
                     LQASVTSV"
     misc_feature    544..780
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     misc_feature    544..780
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     exon            677..2942
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..9393
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtcagca gttgtctctc ctcagttgag cctctttgga aacctctctt agacacacct
       61 tgtctcctag gtgattccag acaatgaaga ctgaccttca tggacgaact gggtagattt
      121 gggtggcttt ataatgaagg atccagccaa attgaaagat aattgattaa ttgggggggg
      181 cattggtaga aggctccact cctgagacac aagttcagtc tacagtgact gaccatgagg
      241 aaagagttaa gtatgtattg gaaaggaaat tcacaaccaa gccatgtctt aaaaagcaca
      301 aaaggtataa gttatggggt tgttttatta agtgcataag gccatgatag tcaaagcatt
      361 acctggttta gtaacagcta cagagggatt gtcagtgata tataatagct aacgtctatt
      421 acactcaaag attagtggat gctgagtcca tgatgtagcc agagtagtat ggcaaggaga
      481 accctggtgt ccacagcatg gagaaagtga gcttggtggt caggtgatgt gtcaccaatc
      541 agtatgtccc ccatcagtca atctcagttt attccactcg gggaaatcct ttgcttggcc
      601 atctcggcaa tgaactctgc gagaaagcct gtcacccagg aggcgctgat ggaacacctg
      661 acgacgtgtt tcccaggtgt tccaacccca agccaagaaa ttctacggca taccctaaac
      721 acactggtac gggagaggaa aatctatccg actccggatg gctatttcat tgtgacccca
      781 cagacttatt tcattactcc ttccctcata agaactaaca gtaagtggta ccacttggac
      841 gagagggtac ctgacaggtc tcagtgtacc tctccacaac caggaaccat aacgccctct
      901 gcctcaggct gtgtcaggga aaggacatta cccagaaagc actgcgactc ttgccactgc
      961 tgccgagaag acatgcacag catgcatgcc tccactctgc agaggaagcc cgccaaggac
     1021 tgcaaagacc cttactgccc tcctccgctg tgccaggtgc cacccactga taaaagcaaa
     1081 agtactataa atttctctta taagacggaa actctctcta aacctaaaga tggtgaaaag
     1141 cagtccaaga aattcggcct taagttattc cggctgagtt ttaaaaaaga caagaccaaa
     1201 cagctggcca atttctctgc ccagtttcct cctgaggagt ggcctctgcg agacgaggac
     1261 acgcccacga ctatcccccg ggaggtggag atggagatca tccgtcgtat caacccggac
     1321 ttgacggtgg aaaatgtcat gaggcacact gcactgatga agaaacttga agaagaaaaa
     1381 gctcaccgga gcaaagccgg gtcctccgcc caccacagtg gaaggagtaa aaagagccgg
     1441 actcaccgaa agtcccacgg gaagtctcgg tcacacagca agactcgagt gtccaaagga
     1501 gatccttcgg atggctcgca tctggatatc cctggtgaga gggagtatga attttgcgac
     1561 cctctaacca gggcccccag agagggctgc ttcatcattg aacacaaagg agacaacttc
     1621 atcatgcaca gcaacacgaa cgtgatcgag tcccatttcc ccatgacgcc agaatgggat
     1681 gtgtctggcg aactggccaa aaggagaacg gagatgccct ttcccgaacc ttccagggga
     1741 agctcccact ccaaagtgca ccgaagccac agccataccc aggaccggag gtccaggaat
     1801 gagaggtcca acaaggccaa ggagagatcc aggtcaatgg ataactccaa aggccccctg
     1861 ggcgcttctt ctctcgggac tccggaagac ctggctgaag gctgcagcca agatgaccaa
     1921 acagccagcc aatcatacat tgacgacagt acgttaaggc ctgcgcaaac gattggtcat
     1981 caaagggctc atattccttc tgccagctat aaagaggtgt gcattccaga aatagttggt
     2041 ggcagcaagg aaccttctag tgcttgtagc cttttggagc caggcaaatc ccctgagagt
     2101 atgccgtctt atggggaact cagcccttgc ccggcaaaaa cagctgtgga tgactatttt
     2161 cagtgcaaca cttctagtga gactgtgctc acagcaccgt ctcctttagg gaagaataag
     2221 gaggaccacg acactttgac cttggtggag ggggtaaaaa agctgtctcc atctgagagg
     2281 cagacccccc actcttccag ggatcctgtt gggcacaagg aggagtcacc aaaagggcca
     2341 ggtgggggcc ctgcagcttc tggtggtgtg gcagaggggt tggccaatgg ccgtcttgtc
     2401 caacatcata gtgcagaacc cagcaacttg gacaaaagga aagaaatatt cagcaaagac
     2461 acactgttca aacctctaca cagcaccttg tctgtaaaca gctatcacaa atccagcttg
     2521 tccctcctca aatctcaccc gaagtcacct gctgacacac tgccaggccg atgtgagaaa
     2581 atggaacctt cccttgggac gtctgcggcc caagccatgc ctccgtccca gcgtcagcag
     2641 gagcctggag ggaaccagga ggcctccttt gactattaca acgtctccga cgacgacgac
     2701 tctgaggaag gggccaacaa aaacacagag gaggagaaaa acagagatga tgtgggcacc
     2761 atgcagtggc tcctcgagag ggagaaggaa agagacttgc agaggaagtt tgagaagaac
     2821 ctcaccctcc tcgccccaaa ggaaaccgat agcagcagca accagagagc cacccactca
     2881 gcccggctcg acagcatgga cagtagcagc atcaccgtgg acagcggatt caactcccca
     2941 cgcactcggg aaagcctggc ttccaacaca tcaagcattg ttgaaagcaa ccgccgtcag
     3001 aatcctgctt tgagtccggc ccatggcgga gctggtccaa ccttcaactt ccgcgccagt
     3061 acggatcccc cgaccagcga agctgagaaa ttacagaaac cttccaactg cttgcaagct
     3121 tctgttacta gtgtatgatt gtccttctgc ctcagatctt ctgtctcatt cgatacagca
     3181 acgtttacga cgattgggac tgatgtttac atctcttcaa aggcaaacat ctcaagcaca
     3241 ggttgggggt tacttgagct gtgctgctaa gtaggctagg gcaaaaaaaa aaatcttcat
     3301 ttcagagtat tgcttttcac atgtatggct ctgtagctac caaatagcag tatgggagat
     3361 acgtacactt ccgcttcact aattgtatct gagcacacat aggaaagtct aaacactgta
     3421 agtggaacat gcatttttcg atgtcataca gttgccaatt ccattctgaa aatgccacag
     3481 agatgtgttg ctccctgccg gcctacgggg tacgggccgt gggactcatc cttgataacc
     3541 ccgccccctc aaacccccgc cccctcaaaa aaaagccaag ccgccacaaa atgtaaatgt
     3601 aggggtgtgt ccattgtgag aaaaaacagt gccaaactgg gcagaaggga ccccagccct
     3661 ttatgtgtga gtcctttaaa gtaccagtca tttttcactg tgagttttca cgacactctt
     3721 gcaggagccc atggaagtgg gtcagaggtc ccaatggaag ttgttggggt atttgttttt
     3781 actgttttcc agctcactaa atgcttgtct tgagtttttt gtttttttaa ccttccctaa
     3841 tcacaaacag gaatataggc ctttgaggtg gacaaaggaa aggaaatgcg gtctcatggg
     3901 ggcacagcac tgagtgctgg agaagggtgt gtggatgacc aggagggatg aatcagatac
     3961 tggagaagga tgcttccctc cttgggacac ttaggatgat cgagctgact atattagatg
     4021 cggtgattaa tctgttggga agtaaaatgt tctttatgat acaaatgaag aatgtggccc
     4081 gagggtgtta ttctttctaa tggaagggac ataaatctat tttatgtagt tttaaataga
     4141 atgcctaaat taggctgtgg agatgatttt tagtggttgt aggaaaagag caaatttagg
     4201 gagagttaaa cttcaggcct tttattcctg ggaagatatc tatagagaca acatttaaag
     4261 taatttttga ttagaaatat acatgggccc atgtaatgaa cagcagaatg tcctcattct
     4321 gctggcgtgg tatattctta atttgtactc ccctaaagtg tatcagaatg acacttatgc
     4381 attcatgaac tatgccagag taatgtttac agatactttg tagtgatttc aggaggcgcc
     4441 ttttgggtgg acatcatctt tgcaatgact tctccaagct ctgctttggt ttaagacgtc
     4501 atgctcagta tcccaaggct ttgcaggagg gggaccacta accattacac ttcagtccta
     4561 ccagaaaggc tctcttcaaa agtcccttga tcttattttc tgagacgcgt ggcatacctc
     4621 tgtaggttct gaaaatctta tctgcacgtg ggttaggtct gatctcagaa aatggtctga
     4681 aacaaaatta cattcagttg agtgtcaaat gatttttgga gccatatgct ttaatgaatt
     4741 tatagataaa taacttaaaa atcagtataa aatattttca ctcaagattt cagcaatgag
     4801 cataagtttg tgagctactt ctttttctgt gtcaggctga atcactagca aggtgtctaa
     4861 gggagcacag tcatatgaag cagttggaaa catgtacatt cattttgtct gctatttgga
     4921 agttgtacta ttgggtcaaa ctgggctcct taagcttggt ataaatttct ttttcttgct
     4981 tattgtaatg aagcttaagc acagttctca gtatactgct acattgttga aatgcttaag
     5041 ggaattggct tcgaatccca tactctactt cctcctggca tgcctcagtt gttcagaagc
     5101 acattgtttc tctgattact taagtaatgt ccagaaagag caaccatgta tctgattact
     5161 acatagtctg tttgcttaag gagccgtaca ccataagatt cctggatctg gtctaaatca
     5221 atttgccccc cccaccccgc gccctaaaaa aacctgctct gaaacttttg gcatactcag
     5281 ttcataaata acagaactgt taaaacaata cactaatctc tgattgacct ctgaacatag
     5341 tagccattga aagaattgag tgccgtgcga gcaggagagg acataattat gttttaagcg
     5401 aagctttaaa atatgcattt ttgatagttc accaaaaaca ggtttacaga agacattttc
     5461 caaacaaaat gtgtacacta tttgcctaat cactatggag tacaagattt aaaaaaataa
     5521 taagtggata agcaaaagaa cttcccttag accagcagcc attagcactg aacgatgggc
     5581 tttaaagatg atgtaacaca tacacagaca ttccgtggag aaacactctc gtctgaatct
     5641 aatctggatt cttgaatgga gaggcattgg tggtaggagg cacatggcag tgtgatgcgt
     5701 acatgtgtct aagatggtct cctcaaaatg gtgagactct ttgactctca cagcctcgag
     5761 actctctcca ggcttcgtca gttttctcca ctggaaccat agctctgtgt tctgtgacgg
     5821 catgtctagt tttagagttt atcaacggaa aggtttacaa aactgaatct ggttgaatct
     5881 ctgtgaggca ttcaacttta aagggtcaac acatctgtcg gcattttgca cacgtatgta
     5941 ttattatgat acagcatatt actttatggt aatttttatt ttttacatat aactacctcc
     6001 atgaatttga tgaaatggca gcagtgtgtt taagtgtgtt cttcagaaaa agcaatgttg
     6061 caaacgtgtt tcagcggtag gccatggcgt ggcgtgtgtg tcggtgactt acccattgga
     6121 ctcatgacct tttcattgcc gtgattttct ttcacaacat tctttggctc ccaactgtaa
     6181 gcctgttgtc ctctttttct ctctcccttc tcccccatga aagcacattt gatttgttac
     6241 aaatgaacga acattttaaa attactgtct tccctgcttc tacacgctca ctattagaga
     6301 aaaaaaaaag tcttctctgg caaagagcca cttggtaaac atttaggaag ttattaattc
     6361 ctatagaaat tacattgaat tgttagggtg tttttttccc cagtaacaaa agatatgtga
     6421 aaattttgga ctgccaactt gaagcacttt gggcctctct gcctctatgc taccctatgg
     6481 agcccaaact tttttttatt aaaagaactg tgccatgcat tctgagatgt ctgttaagta
     6541 atttgtctac cctttgattg cacatctcag gagactttaa tgagtgcaag aatagggtgt
     6601 gtgtgcaccc aatagagaaa accaatgtga gagctgaaat gggagtagcc gggtagaaat
     6661 aagaaatgcc ggtgtctttg atgttggaga attcaagttc aggaaatatg aatggaaaga
     6721 gaatgtggag gagcagtgat ttgaacacca gctgttccta aatgtctctt ttctgagaac
     6781 tcagccaata ttgttacaat gtcaccaaga caggaaaggc agtaaggaca gaagaacata
     6841 gtttctcttt taggttagca tagctttgta aagtcctacc taggattatc cactggtcac
     6901 cacaaagtgt acttgaagat aaagtttgta acttcagtga taggcacagt tctcacaaaa
     6961 ccatttggga ggggtagcgt tctgagcttg cactaacaac caacgactgg taatgttctg
     7021 cagctcatct ggcgatctca aagtgcttcc gaggcattag gcgtacaatt gcagggcagg
     7081 tccagtttct catacccagg cttgacagga gcaaacaaat ggagtgtctt gagatcaccc
     7141 ataaacacaa tggcagctct cagtgaccta ttttctatct gtttgatagg ccatggtgag
     7201 aaatcactaa gatgctattt ttatgatgtg tgctaataaa gaaaacaaat acagcttgac
     7261 accttgtcca tttcattcaa agaggtatgg gtgtttggaa tctcagcacc tcagcacccc
     7321 ttactggtat tgagttatga cgtgggagag gagcaaatcc acaccaatgc cactgtcatc
     7381 caaagccagt ccaggcatcc acctttgttt acagctcctt attaggtccc tgtcatatct
     7441 gtgttaaaac aaaaccccat ctccaggaac attggctgct ccaggcagtg gaaggtgctg
     7501 aaacagttgt gttttttttc tcttaatttt cctttaaaat attcatcaag cactcctcac
     7561 agtgttcagc aacataccac tcactacgtt atatcaagcc ctgcttcgta gaatctggga
     7621 agctgatcca gttccaagag ttttgtcaaa ttatgagata gaaggtcttt gacttctgct
     7681 ttctcctttc ccacagacca gacccacacc caactagcag tgcagtgcag accacagtag
     7741 actcgaagtg gtgcttcctc ccccgacccc cgacccccat ccattgtcaa agccatccaa
     7801 taatgtcctg tgagcgaggg actctttggc ccgtgtttaa ggcttgggga aattagaaac
     7861 aagaaaaatg aatgcaaaaa gccatgggag gcattggttt cctttgggct agttaaacat
     7921 ggtggcaagg gattgctatt gtatgagctt tgccaagaaa tacaaaagac tcagccatca
     7981 ccccatcctt ctcgaagaag gttttatagt attaatgata caagtgatat tttcccatgg
     8041 agttttcctt aggatacatt tcataaatta tacacatgag acattttagc attagatctc
     8101 atgtgtttgc caaaggtact ggcttctccc tggcttggag tccatcctct tgtcttgcat
     8161 cagcaacgca gaggggctcc tcggtgatgg cttctagaat acatatgcct gtgtctttat
     8221 tgttgtgcac aggcttaaca tttgcaaaat tgagaattcg gcaaagctcc aggggaacta
     8281 agcggtcttg tgattgtatg caggcagtca gaggccttta atggctcatt gtcggcttca
     8341 cttgtgaaca catacaccct cccgactagg aaaagggtgt ttccaggtga ggtaccaatg
     8401 gcttggaaag gcagaaatgg aaggttagag cttggctggt ccttgtgcac ctgcctacct
     8461 ccctgtccaa aggctgacct tggtacccgc ccccccccca ttccccttct ctcaccccaa
     8521 aagaggtacc aaatctgaga cccgagctct ccttcaatcc cagtcctcta cagctccagg
     8581 accttcatat agaacattct cgacagcccc gccttccttt cctctgagcg ttaccctctc
     8641 cgcctcccca ccaccaccag atacctaccc caccaccact ctttccacat tggaagaaca
     8701 gaatactgtg tagtattgtg cacgcatgcc agttaggagt agaactgccc tagggtcacc
     8761 ttcacatcag tgtcaacagc tacaaacata aagtccttag agcagtcaca tccatactct
     8821 ctggaagaga attcaatttg accatctaag ttccaaggga tcgtggctct gcgggcgtct
     8881 ttctctgtgt ggctgactgt gactattaca ttagggtcag tgagctaaga agtacgtgtg
     8941 ggattcactg tgttaggaag gagttttgca gccaagactg ccttgaataa aaatgttttt
     9001 gcactgaaaa aaaaaaactt taaatgactt ggtctctggt tgctgtaaag gtcatccaag
     9061 atggatgttc tgtttatatt gtatagtatt tcataagaaa taactgcagt tcatgaaacg
     9121 tcttccctaa tgttactgat ttctaacagc acatttgtaa catggttttt atcgtgtccg
     9181 tgtaccatac tgtaaatgat gattccttgt catgcttagt ataataagtt aaaaggaaaa
     9241 aaaaaaagga cagggatttt tgtaagtcta tatttgaaag tccctccata tggtaatatt
     9301 gtgttcatgt tgtttatgta gtgttgtgtg aaatatccat tttggattgt gttacttttt
     9361 aagatattaa ataacatttg gttatatgtg taa
//
LOCUS       NM_001436820            2508 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus zinc finger, MYND-type containing 12 (Zmynd12),
            transcript variant 2, mRNA.
ACCESSION   NM_001436820 XM_017593392
VERSION     NM_001436820.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017593392.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29785.1,
                                           SRR26360190.2313279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000005.1  138312324-138312458
            136-277             JAXUCZ010000005.1  138324301-138324442
            278-449             JAXUCZ010000005.1  138327713-138327884
            450-619             JAXUCZ010000005.1  138333334-138333503
            620-742             JAXUCZ010000005.1  138336285-138336407
            743-854             JAXUCZ010000005.1  138339497-138339608
            855-1000            JAXUCZ010000005.1  138341575-138341720
            1001-2508           JAXUCZ010000005.1  138343762-138345269
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2508
                     /gene="Zmynd12"
                     /note="zinc finger, MYND-type containing 12"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
     exon            1..135
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1093
                     /gene="Zmynd12"
                     /note="isoform b is encoded by transcript variant 2; zinc
                     finger MYND domain-containing protein 12; zinc finger,
                     MYND domain containing 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform b"
                     /protein_id="NP_001423749.1"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
                     /translation="MNVIYPLAVPKGRRLCCEVCEAPAERMCTACTVTYYCGPVHQKA
                     DWGSIHAKICQLLIPLRTSMPFFNSEEERQHGLQQLQRRQEHLIEFCYTVAQKYLFEG
                     RHEDAVPAALHSLRFRMNVHGLSSVELVPAYLLLAEASLGLGRIVQAEEYLSQAQWTV
                     LKSTDCSNATHSLLHRNLGLLYIAKKNLEEARYHLANDIYFASCAFGTEDVRTSGGYF
                     HLANIFYSLKKMELADTLYTKVSEIWYTYLSSHYQALLHARTQQTDLLGKQFMNDTGL
                     DEAQEAEAIRILTSILIIQESTSTQAPQKGILILKTLGILYYLMLEFSKVWACFASAL
                     GVSRHQHGPGWKEGKETCLGG"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    254..>817
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    254..>817
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    419..511
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    419..511
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(425..430,437..442,446..448,542..544,551..556,
                     563..568,572..577,668..670,677..682,689..694,701..703)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(425..430,437..442,446..448,542..544,551..556,
                     563..568,572..577,668..670,677..682,689..694,701..703)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    536..628
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    536..628
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    665..751
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    665..751
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            136..277
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            278..449
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..619
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            620..742
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            743..854
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1000
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..2508
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagactgac gccgctggcc acaccatgaa cgtgatctac ccgctggcgg tgcccaaggg
       61 gcgccggctc tgctgtgagg tgtgcgaagc cccggctgag cggatgtgca cggcctgtac
      121 agtcacttat tactgtggtc ctgtgcatca gaaggctgac tggggcagca tccatgcaaa
      181 gatatgccag ctgctgatcc ctctgcgcac cagcatgccc ttcttcaact cagaggagga
      241 gaggcagcat ggtctgcagc agctgcagag gcggcaggag cacttgattg aattctgcta
      301 cactgttgcc cagaaatatc tctttgaagg aagacatgaa gatgccgtcc ctgcagcttt
      361 gcactccctt cgcttccgca tgaatgtgca tggcctgagc tcagtcgagc ttgtgcctgc
      421 ttacctgctc ctggctgagg ccagccttgg tctgggccgg atagtgcagg ctgaagaata
      481 tctatcccaa gctcaatgga cagtcctcaa gtcaactgac tgtagtaacg ccacccactc
      541 tttactgcat cggaacctgg gccttctcta catagccaag aagaacctcg aggaagcccg
      601 gtaccatctg gctaatgata tttattttgc cagttgtgca tttgggacag aagacgtcag
      661 gacctcagga ggctacttcc acctggccaa cattttctat agccttaaga aaatggagct
      721 ggctgacaca ctgtatacaa aggtctcgga gatttggtac acatatctga gcagtcacta
      781 tcaagccctc ttgcatgctc gtacccaaca gacagattta ctgggcaaac agtttatgaa
      841 tgacaccggc ttggatgaag cccaggaagc agaagccatt cggatcctaa cttcaatcct
      901 gatcattcag gaatctactt ccactcaagc gccccaaaaa ggcatcctta ttcttaagac
      961 tctgggcata ctttactatc tgatgttgga gttttcaaag gtgtgggcct gctttgcttc
     1021 tgctcttgga gtatccaggc accaacatgg acctggctgg aaggaaggga aagagacttg
     1081 tctgggtggt tgacttcccg ggtccttggt ccagcctagt gagtgctcgg ggagaaagcc
     1141 ttctccgtga agattttcag tgttacagct cttctctaca gctcttctct accgtgggac
     1201 ggggacatga catggctttt ctagacgatg ttctgtgaaa gagcccctct ttacttgtag
     1261 gtaaccggct atataaacct tggggagtgg gtaggggttt gtgggagatt atatacatta
     1321 taggctgggg ctgaggggct gggcatgctt tatctgcatg aagagggatt ccaggtactt
     1381 tggccatcaa ggctgatgaa ggtggaggaa gtggggaggt cagggctaca aaggcatgca
     1441 ggcctagaac aactagggag tgatccttac tcttgttggt ctcaagatga gattggacac
     1501 atcctaacct cactcttgct tcaggcccat gttgtgccca ccctgccacc cacctcccac
     1561 ccacacccac cctcctaccc tctactctcc cacccccatg ctcccttgac ccacactcag
     1621 gaggtagaga cagtaggacc ataaattcaa ggtcattctc aactatacag caagtttgag
     1681 gtcagtctgg gctatgagag aacctgtctc aaaataaccc ctagtatcat cgtgtttttc
     1741 ttatcgtgct gtctgtcttt cctgttctgt gtatggttca caaggacacg ggtttctgtc
     1801 tgcgtcccct ggcagatagc agccatctga taacgagaaa agggcaaagg ggatagaaac
     1861 cagagactgc cctgaggtag atagcccacg aagcctctgt ccaagtcaga actcagggcc
     1921 ccaaggtctc cgggacattc tgcttctggc acctgtgagc cctctgcctc ctggttctgc
     1981 tccacggctt aagaccatcc cggctagttc tcactctgct aaggaggtct acctgcctgt
     2041 cactttctgg tcaagtcagg tgagctttcc ctggctgggg agagaaggcg atcgatcgat
     2101 ctctccccag tttctgagct aagcacaaaa tcctttctca ttgttactct tccctgtggc
     2161 agcttccact cagcactgca attctgtttc aggcgaagga atatgccacg aaagccctca
     2221 gtctagctga ggtgtatctc agtgaggagg agcaaggggt tattcaagag ttgctgagtg
     2281 ccatcttggc tgaggagaag cagctcacga cctagaggcc accttgctgg tgctgccgtg
     2341 ggctgtgggc tgtgggctgt gggctgacta gtggtgcaga gctgctcaca ggtcctctgg
     2401 cctgctccca cccctccctg gggaccgcct gaggggctgt gatcctgtca gctggtgacc
     2461 tagagctttg ggcgcagtgt tcaataaaat ttgtttatca tgaccttg
//
LOCUS       NM_001436807            4666 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 3, mRNA.
ACCESSION   NM_001436807
VERSION     NM_001436807.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4666)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4666)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74882.1,
                                           SRR26360181.148505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000016.1  52858368-52858535   c
            169-1265            JAXUCZ010000016.1  52848306-52849402   c
            1266-1534           JAXUCZ010000016.1  52836572-52836840   c
            1535-1685           JAXUCZ010000016.1  52822585-52822735   c
            1686-4666           JAXUCZ010000016.1  52818691-52821671   c
FEATURES             Location/Qualifiers
     source          1..4666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..4666
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..168
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    137..139
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="upstream in-frame stop codon"
     exon            169..1265
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1813
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 1"
                     /protein_id="NP_001423736.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQNDDDFKEG
                     INKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKPKFPSKE
                     QHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYYTDGEES
                     SDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIGSDMQNK
                     PDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPASTPDSSP
                     AQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQNFAPKSS
                     VLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNYSFTREE
                     VRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQRIERENM
                     ALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRGASRTSS
                     ATSGLSCKTDRSVLDTSSGFLLRPKPPNVRTAWL"
     misc_feature    206..208
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    239..241
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    437..1075
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    647..649
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    662..664
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    665..667
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    887..889
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    959..961
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    1247..1555
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1247..1555
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1403..1477
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1266..1534
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1685
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..4666
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattagcagg cagtgaaagg caggaggtgg ggcctaggtg gaagaaggtc actagaggta
       61 tcgctataga ggttggcctg gcctcttcat gtaggccaga ttctccaacc ttacaattac
      121 atgaactgct gctctgtagt gccatgaagg actgaaccct ctaaaaatat atacttttgg
      181 catcatggat cggtttggcg atatctcaga aggtgaagtg gaccattctt tctttgacag
      241 tgattttgaa gacacaaaga aatgtgaaag taattccatt tttgacaagc aaaatgatga
      301 tgactttaag gaaggaataa ataaggacat caaaaattta aacttgaaat ttggagtaca
      361 aaatgataac cttaaagaga aaatagataa tgacacagaa aatgtgaacg tgaaacttgg
      421 gatacaaaca aaggaaaatt accttactca gaagggaaat gaaaggaaac caaaatttcc
      481 ctcaaaggaa caacatgtag aaaatgaccc tatacaaaca agaagtccct cattgttgac
      541 ttcttcaagg tcaaaaaaac tgtgtgatac cacaaaagga aataaactac atttgcctgt
      601 tccaaataga attcctaaaa ttgtgaaagg tgaggatgac tactacacag atggagagga
      661 aagcagtgac gatgggaaga agtaccacgt gaggtctaag tcagcgaagc cctctagtaa
      721 cttaaaaaag aacaacacaa gtaagaagta ttccaaagcc agttcctcct ctctgtcttc
      781 ctcatcttca cgatcaagct cagactgctc agatatagga tctgacatgc aaaataaacc
      841 tgattcaggt tcatcaggga aacgagtttc tagtgtaacc ccctcatcac caaagcagaa
      901 gtgtaagtca ggaagaaaat caagtgctaa acagaaggca ggtgactata atgcagagtc
      961 agaagacaac gtaacagacg taactcccgc gtcaactcca gacagcagcc ctgcccagcc
     1021 atttgagttg agccaatcac agaatcaaaa agtaaaagtt aaaagacaag aaaatgtgag
     1081 ccgggatgtg tatgaggatg tggaggcttt aaagaatgat tcaagatgtc tgaaatcagc
     1141 caaaaggaaa gaaaagcatg gacagaattt tgctccaaaa tcatcagtgt tagatgcaaa
     1201 tctagaccgt agatccaagc aaaaagtctt acatgacaca atggacctta atcatctgtt
     1261 gaaagctttc ctgcagttag ataaaaaggg accacagaaa catcactttg agcagccttc
     1321 aataatacct aggaaaaact actctttcac aagagaagag gtgagacaga ttgatcggga
     1381 gaatcagagg cttttgaaag aactgtcaag acaggctgaa aaaccaggaa acaaaagtac
     1441 aattcctgga agatcgctcg gccatccacc taagttgtat cacagtgctc tcaacagaca
     1501 gagggaacag caaaggattg aaagagaaaa tatggcttta ttgaaacggc ttgaagctgt
     1561 gaagccaaca gttggcatga aacgctctga acagctgatg gactaccatc ggaatatcag
     1621 ttacctcaac ccttcaccgt ccgtcagacg agtgagatct actcttggcc attacagccc
     1681 actgagagga gcttccagga catccagtgc aaccagtggt ctcagttgta agactgatcg
     1741 atcagtgttg gacacatcca gtggcttttt gctaagaccg aaacccccga atgttcgtac
     1801 tgcttggttg taaaaccttt ttttatgata tacattgttc atctgttggt cctgttttaa
     1861 cgatgtattt ttctgtacta ctataactat ttgcaaacat ctgtcatact tttccaacaa
     1921 tttatacagc aatgagtata atttattgtt attcagtgca aattgttatc aaaagacact
     1981 ttgatgtaaa atcagtgttt catgcagtgg catatttata ggagccatat gtctatttca
     2041 tagagaaagg tgtatgcatg aatgtttctt cgatatagga attcagctgt tgtgctgaca
     2101 aagcagcagt ggtggtaatc catgttgaaa ccaagacgct cactatatag ttcttaatct
     2161 atatgagttt cagttattgt aagcgttaag gtgctttacc ttgtaaactt aagcgcctca
     2221 tgcttctgtc tgctttagac tgtctgtaac acgagtcagc acttgcttat gtgagtgttc
     2281 cactccaaat gaaaaaaact tgaaatttgt tttcatggag aagctggtgt agtcttgatg
     2341 aggagcatga gcagcttgta tcagtgcagc tcttgcttga ctaacgacgc ttctccctaa
     2401 gtctgattat ctattccaaa ccgtttcacc ccatgaatga ggggttcact ttagaagcgt
     2461 ctgtttcatg tttatatgca gtctggtaaa atacccttaa ggattctgag gcaagagaga
     2521 ggctttaaca gcttcgagtc ttgtgacttg tgactggttt ggatccagat catttgcatc
     2581 attaacaaaa gcatgtgttt atggatcagg gagcaacatt cccagcttga agaccagggt
     2641 gtgttagagc agtgtttgaa atgatactgt tagtgtgtgt gctgtcgttg tgtatttatt
     2701 gtattaatag aatgcttaga gtaaggaaga aatgattaga gaaaccaaat acaaacaaga
     2761 aagaaactaa tcacacattg gtcacagcta ctgccttaat gttagtgaat gtccttggct
     2821 tgctttagct gagtcctgga agcaccagtc ttcagtctca tgtttgaagg tctgttaatc
     2881 ctcatggact tgctagtgac ccacagatgt gaaatagttg actatgaaaa actagaatat
     2941 tttcctgtca acctagaggc tgttcttttg tagaacaaag tgtgtgatat ttcatagtca
     3001 tagcctttca ttgctggtct tgtcagtatg cctttagtaa atacctttta tattcaatga
     3061 cacgcttttc ttaaaatatg aattttccct gaccacagag agatctgtct ggttcagtgc
     3121 tcagcactgg agcatgtggg ccacacctgc ttcgccttcc gtagcaggga ggccgactgc
     3181 ccttaccaag caccaggtca cacattgtta gtctcacttt aatggatggt gttccagata
     3241 gagcagtgat ggtaggaaat ggtgagacca caacaatgct gatatacata gcatacacac
     3301 acatacactc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     3361 tcacacacac acacacacac acacacacac acacacacac acacacacac acgactaagg
     3421 gtttttctgc tgcttttgga ggactgtaac attctataac aatttatttc tttgttttag
     3481 tgaacaagat tttgtacctg ctctatatac cccttttaat gtttttgtaa caacttaaat
     3541 ttaaaatgca acattttggc atttgctcag tagtgaatca ctttaaagca gatttttgtg
     3601 ggaaaaaaac ttgtatatgt aaaaccttct atgttcacag tggcattagc ctaggcacat
     3661 ttttgttggt ctctccaagt tccatagata aactagaatt tgattttaaa tgctaattta
     3721 tgtcttagtt tttactgttt ggaagaagtt taactaagtg ttactgatga caaggattca
     3781 acctcaagta aagggcaacc atcttttaaa agcaatttag cttgttatat tgtaggtgca
     3841 tagatctggt gactgtagag atgggtagga gttatactca gaactcactg atggacgtca
     3901 aggtactgtt aggtaggatt aggaagcctt tgcaatggag gagtcatgag tacattaatc
     3961 tcttcagcct caccaacaca aacatgtact cttagcactg ttgcatggtt ggctggctgg
     4021 tccttaccaa gcatacttgg aaggcccaca tctgtagcta gaaagcgtgc tggtctgctg
     4081 cctagagaca gatctgagaa ctgttttcat ctctgtcaaa tgttatctcc ttttctagta
     4141 agtttttgtg agatttcaaa ttattaaaat tacttcttaa ggagtagcta ctacctcatc
     4201 ctccccaact gactctttca gtccccatca aaacctgctc taactgctat tccagttaac
     4261 actctatggc ttgcttgttt aataacatca tgcacttgtg ctcaacccaa gtatcagaaa
     4321 cgcgactcgc ggctttgaga ggtgattgtg ataggtctgc ttctcatctg cagatacaat
     4381 gcagcaactc caaagtatta agatcacact aagctgaaga tgcacctttg ccctggttag
     4441 caacgcaaaa ccgtatcgtc atacatgcca aggccttagc gtgtagatgt ctgtacaccg
     4501 gcacagcgaa tgagctcact gctaatggct gagttgctta ttttcatgaa caaagattag
     4561 caagaaactg ttaaaccatc tttttaaaaa ctgttctagt ttgtcatatt ttaggcatga
     4621 agaactagct tggcttactg aagaaataaa agatttaaag agaacc
//
LOCUS       NM_001436814            2546 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 9, mRNA.
ACCESSION   NM_001436814
VERSION     NM_001436814.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74840.1,
                                           SRR26360181.1778769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  52866894-52866960   c
            68-176              JAXUCZ010000016.1  52866109-52866217   c
            177-629             JAXUCZ010000016.1  52856986-52857438   c
            630-1726            JAXUCZ010000016.1  52848306-52849402   c
            1727-1995           JAXUCZ010000016.1  52836572-52836840   c
            1996-2146           JAXUCZ010000016.1  52822585-52822735   c
            2147-2253           JAXUCZ010000016.1  52821565-52821671   c
            2254-2546           JAXUCZ010000016.1  52818691-52818983   c
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2546
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..67
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="upstream in-frame stop codon"
     exon            68..176
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2292
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 6 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 6"
                     /protein_id="NP_001423743.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MWTRLVWTPSEICLPLLSEYWNQRITRLQHLCRKPSQMSKPTAA
                     SWLYEQVMPWTAGRPWRSPFHEPPSLLEALPRSCRPYSAGLITVTGSLGTMDDRSAAR
                     TIFGRDSVPRSPRLSPSAESLPRSFRPRSRVRESPLASNAWEGEMWCGCACAERTRTR
                     TLGAARESVAATVPRYTFGIMDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQND
                     DDFKEGINKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKP
                     KFPSKEQHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYY
                     TDGEESSDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIG
                     SDMQNKPDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPAS
                     TPDSSPAQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQN
                     FAPKSSVLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNY
                     SFTREEVRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQR
                     IERENMALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRG
                     ASRTSSATSGLSCKTDRSVLDTSSGFLLRPKPPNIQCSNSKVLRSH"
     misc_feature    1708..2016
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1708..2016
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            177..629
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1726
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1995
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2146
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2253
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2546
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaccgcg tctgttcgtg gaaaattttg ctgcaggtgt cagaagcttg agtactgctc
       61 ggctcagggt ctctctgtgt aaacctggct atcctgaaac tcactatgtg gaccaggcta
      121 gtctggactc cctcagagat ctgcttgcct ctgctttcag agtactggaa tcaaagaatt
      181 acaagattac agcatctttg taggaaacca tcccagatgt ctaaacctac cgcagcgtcg
      241 tggctgtacg agcaggtgat gccctggaca gcagggaggc cctggcggtc tcctttccac
      301 gagcccccaa gtcttctcga ggccctgccg agaagctgtc gcccctacag tgcaggcctc
      361 atcactgtga cggggtctct tggaactatg gacgacagga gcgctgccag gaccatcttc
      421 ggcagagact ccgttccgcg atcgccccgc ctttcccctt ccgctgagtc tctccccagg
      481 agcttccgcc cgcgctcacg tgtgcgcgag tctccgctag cttccaacgc gtgggaggga
      541 gaaatgtggt gtggctgcgc gtgcgcagag cgaacgagaa cccgaacgct cggcgcggcg
      601 cgagagtcgg tagcggccac agttcccaga tatacttttg gcatcatgga tcggtttggc
      661 gatatctcag aaggtgaagt ggaccattct ttctttgaca gtgattttga agacacaaag
      721 aaatgtgaaa gtaattccat ttttgacaag caaaatgatg atgactttaa ggaaggaata
      781 aataaggaca tcaaaaattt aaacttgaaa tttggagtac aaaatgataa ccttaaagag
      841 aaaatagata atgacacaga aaatgtgaac gtgaaacttg ggatacaaac aaaggaaaat
      901 taccttactc agaagggaaa tgaaaggaaa ccaaaatttc cctcaaagga acaacatgta
      961 gaaaatgacc ctatacaaac aagaagtccc tcattgttga cttcttcaag gtcaaaaaaa
     1021 ctgtgtgata ccacaaaagg aaataaacta catttgcctg ttccaaatag aattcctaaa
     1081 attgtgaaag gtgaggatga ctactacaca gatggagagg aaagcagtga cgatgggaag
     1141 aagtaccacg tgaggtctaa gtcagcgaag ccctctagta acttaaaaaa gaacaacaca
     1201 agtaagaagt attccaaagc cagttcctcc tctctgtctt cctcatcttc acgatcaagc
     1261 tcagactgct cagatatagg atctgacatg caaaataaac ctgattcagg ttcatcaggg
     1321 aaacgagttt ctagtgtaac cccctcatca ccaaagcaga agtgtaagtc aggaagaaaa
     1381 tcaagtgcta aacagaaggc aggtgactat aatgcagagt cagaagacaa cgtaacagac
     1441 gtaactcccg cgtcaactcc agacagcagc cctgcccagc catttgagtt gagccaatca
     1501 cagaatcaaa aagtaaaagt taaaagacaa gaaaatgtga gccgggatgt gtatgaggat
     1561 gtggaggctt taaagaatga ttcaagatgt ctgaaatcag ccaaaaggaa agaaaagcat
     1621 ggacagaatt ttgctccaaa atcatcagtg ttagatgcaa atctagaccg tagatccaag
     1681 caaaaagtct tacatgacac aatggacctt aatcatctgt tgaaagcttt cctgcagtta
     1741 gataaaaagg gaccacagaa acatcacttt gagcagcctt caataatacc taggaaaaac
     1801 tactctttca caagagaaga ggtgagacag attgatcggg agaatcagag gcttttgaaa
     1861 gaactgtcaa gacaggctga aaaaccagga aacaaaagta caattcctgg aagatcgctc
     1921 ggccatccac ctaagttgta tcacagtgct ctcaacagac agagggaaca gcaaaggatt
     1981 gaaagagaaa atatggcttt attgaaacgg cttgaagctg tgaagccaac agttggcatg
     2041 aaacgctctg aacagctgat ggactaccat cggaatatca gttacctcaa cccttcaccg
     2101 tccgtcagac gagtgagatc tactcttggc cattacagcc cactgagagg agcttccagg
     2161 acatccagtg caaccagtgg tctcagttgt aagactgatc gatcagtgtt ggacacatcc
     2221 agtggctttt tgctaagacc gaaacccccg aatatacaat gcagcaactc caaagtatta
     2281 agatcacact aagctgaaga tgcacctttg ccctggttag caacgcaaaa ccgtatcgtc
     2341 atacatgcca aggccttagc gtgtagatgt ctgtacaccg gcacagcgaa tgagctcact
     2401 gctaatggct gagttgctta ttttcatgaa caaagattag caagaaactg ttaaaccatc
     2461 tttttaaaaa ctgttctagt ttgtcatatt ttaggcatga agaactagct tggcttactg
     2521 aagaaataaa agatttaaag agaacc
//
LOCUS       NM_001436799            4629 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 5, mRNA.
ACCESSION   NM_001436799 XM_039109957
VERSION     NM_001436799.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4629)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4629)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4629)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039109957.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.22223.1,
                                           SRR26643297.19507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000005.1  123105696-123105769
            75-175              JAXUCZ010000005.1  123106498-123106598
            176-200             JAXUCZ010000005.1  123118303-123118327
            201-346             JAXUCZ010000005.1  123122432-123122577
            347-508             JAXUCZ010000005.1  123130554-123130715
            509-641             JAXUCZ010000005.1  123131303-123131435
            642-706             JAXUCZ010000005.1  123132010-123132074
            707-779             JAXUCZ010000005.1  123134055-123134127
            780-931             JAXUCZ010000005.1  123138897-123139048
            932-1013            JAXUCZ010000005.1  123139751-123139832
            1014-1108           JAXUCZ010000005.1  123141269-123141363
            1109-1236           JAXUCZ010000005.1  123146672-123146799
            1237-1376           JAXUCZ010000005.1  123150654-123150793
            1377-4629           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4629
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..74
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            75..175
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1705
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform d is encoded by transcript variant 5;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform d"
                     /protein_id="NP_001423728.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMM
                     EGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADN
                     DDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSE
                     IEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYL
                     PEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFN
                     VKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSER
                     YDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKE
                     DGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNL
                     ATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHEN
                     TND"
     misc_feature    710..859
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    710..859
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1028..1162
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1028..1162
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1028..1030,1118..1123,1127..1132,1136..1144,
                     1148..1156)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1028..1030,1118..1123,1127..1132,1136..1144,
                     1148..1156)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1190..>1630
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1190..>1630
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            176..200
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            201..346
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            347..508
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            509..641
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            642..706
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            707..779
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            780..931
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1013
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1108
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1236
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1376
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..4629
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcggcct tcgcggtggc ggcggcggcg cgagtcttcg ctgcttccgc ggcgcgccgg
       61 gactacgctg cggaatggtg tggtggctcg attctcccag tgcctggctg agtttcggac
      121 gtggttaaga accaactggt tgaggttcaa tgcagacaag acggatgtga tgctgccatc
      181 tgttgagtct tcaagtccag ggggctcagc agcgtcagag gaccatgagt ttgatccgtc
      241 agctgacatg ctggttcatg attttgatga tgagcgaaca ttagaagaag aagaaatgat
      301 ggaaggagag acaaacttca gttctgaaat agaggatctt gcgagggaag gcgacatgcc
      361 aatcgacgag cttctcagcc tctatggtta tggcagcact gttcagttac ctgaagagga
      421 ggaggaggag gaagaagagg aggaagaagg tgaagatgat gaagatgcgg acaatgatga
      481 caacagtggc tgcagtgggg aaaataaaga agagaatata aaggattcat cgggtcagga
      541 ggatgaaact cagtcttcca atgatgatcc ctcacagtct gttacttccc aagatgctca
      601 ggaaataatc cgcccacgtc gatgtaaata ttttgataca aatagtgaaa tagaagaaga
      661 atctgaagaa gatgaagatt atattccctc agaagactgg aaaaaggaaa tcatggtagg
      721 ctccatgttt caagctgaga ttccagttgg cgtttgtaga tacaaagaaa atgaaaaagt
      781 gtatgaaaat gatgatcagc ttctgtggga tccagaatat ttaccagaag ataaagtgat
      841 tgtctttctt aaggatgcat ctagaagaac aggggatgag aaaggtgtag aagcaattcc
      901 tgaaggatct catataaaag acaatgaaca ggctttatat gaattggtta aatgcagttt
      961 tgatacagaa gaagccttga gaagactgag atttaatgtc aaagcagctc gagaggaatt
     1021 atctgtgtgg acagaggaag aatgtagaaa ttttgaacaa gggctgaagg cctatgggaa
     1081 agattttcat ctgattcagg ctaataaagt ccgaacaaga tcagttggtg aatgtgtagc
     1141 attctattac atgtggaaaa agtctgagcg ttatgatttc tttgctcagc aaacaaggtt
     1201 tggaaaaaag aaatataatc ttcatcctgg tgtaacggat tacatggatc gtcttttgga
     1261 tgaaagtgaa agtgctgctt ctagccgagc accatcccct cctcccaccg cctcaaacag
     1321 tagtaccagc cagtcggaga aagaagacgg cacgctcagc aatagcaatc agaatggtgt
     1381 gtcatctaat ggaccaggag aaatactaaa caaagaagaa gtaaaagttg aaggcttaca
     1441 tgttaatgga ccaacaggtg gaaataagaa accacttctt acagatgtgg acactaatgg
     1501 ttacgaagaa aataaccttg ccactgaccc aaaacttgcc catatgactg caagaaatga
     1561 aaatgatttt gatgaaaaaa atgagagacc tgccaaaagg cggcggataa acagcagtgg
     1621 gaaagaaagt ccgggttcgt ctgagttttt ccaggaagca gtctcacatg ggaagtttga
     1681 ggaacatgaa aacacaaatg actaactctt aggcctattt tactttcttt gcagtaaagt
     1741 ctggtttgac tacaattttc agggttgggg gggtgacctt tagaaagctg atttccttga
     1801 agcagttgtt aactcttgaa attggaatta ggtcctaact ttaagaaatg ggattcataa
     1861 ttctactttt tgcaagttct tttacttcaa attttgaagc cctctttaag gatataaaaa
     1921 cattggtaaa tttgaatgac ccaaagactt aactgcacct tctcctttga gaaacaagtc
     1981 atatttgact aaaaggtaat ctttccttat tctttatgag gaagaaaaaa gtttgtttct
     2041 gttcaacacc aatttttttt attatctaga aatgtcttta caacagacat ttttctctcc
     2101 atacaaattg aacatcgtca ttaaggaaac cctcatgaat cctgaaggtt atgctagcat
     2161 gatttttata tgtagaagtt taaaaataaa ccaagtcagg tttgtatttg taaaattgtt
     2221 gacatcaatg atgtctttcc atattcttat ctgggcttaa gaaatacatt ctgtattttt
     2281 ccagattctt tgtagccttt gaaagatttt tacagtacat atgtcttgac tgagctgtcc
     2341 tttcttaata caaaaaaagc ttgtataatt ttcttaactt gtacagttgg taaactttta
     2401 tgagaggaac tgatattctg agtctgtcag ctttcatttt attttgctaa gatttttcta
     2461 atgaattttt aagtgtgtgt gtagttaacc aagtcatgtt tcttatccag gtggtaaaag
     2521 cattcataaa gaattatgtt attttcaaac ttctacttac tgacataatt tgggacttct
     2581 aaatttcagc atgatactca gattacaagc ttgtttgcat ttgctataat tttataaatt
     2641 aattgtgaaa caaaacaaag acttactgtc agcttaagtg tgtagatgta tcgtgctgaa
     2701 tagaatcctg ttcagttact ctcatgtgcc ctacaagatt tctcattgtt tcagtcaaca
     2761 gaaagggaag gtcacgtgat gttgcaatat tgccacatcc aaggagtaac tgttgacagg
     2821 tagcaatatt catttttatg agaaaatagt ggttttaaga attttcagat ctttccagtt
     2881 gtaatccagt ttgtcacatt tgatactttt tccaaaatga aacacataca aaataaccat
     2941 tgttctgtgt gactttaaaa agggttattg cactagcctt gtaagaatgg atgccatttt
     3001 attgttagtg caaaattctt cttacaaaat gtagttttat acagctgata gaccaatcta
     3061 tctctggact gttttttagt gaatgatgat taactacctt ttctcacaca ggcacatccc
     3121 caaatgctgc cttcagtttg atctcagccg tcagttcaag agccactgct ttcaaagaca
     3181 gatctgtgtc cttttagtgg ctcagttgtc tgatgcaggg tgggttaagg tttgcactga
     3241 gaatgatcgc ccaggcctct ccctcatagt attcttacat ttgtccagac tgcttccctt
     3301 cacaatgggt acaaactttt ctttccccaa atcagtatta gaagccacct tgacagcaca
     3361 tcataataat acgcatttac tgttttctgc agaaatagtc cagtgagttg ccttcaggtg
     3421 gaagtgctga gaagcacgag agggtttagt ttgttttatt gaaaacatta atttatccag
     3481 aatggcagta ggtcaagtac ctttagcaga tggtcatagc ttgtctccct gcccaccccc
     3541 acagagtctc actgtgtagc ccaggctggc ctggaactta acaacccttc tacctcagcc
     3601 cgctaatgct gagattggag gtgtttccca ccacacccag caacagtcta ttttctaaag
     3661 caggttttat tatatgagtc caggccatcc cagctccttg tcacaggtga tctttaagtg
     3721 atgctatgct ttttaatcat tacactatgg aagatgtcag tccgcctttt aaaggatgcc
     3781 tctgctcgac acgttcttgg acttctcgaa actgttgtaa caggaacgtt ttaaggaaat
     3841 tctcaggcat gttggcaaat gtgccaggtg tataagtgtt cataaatctt ttctttttaa
     3901 agtatgcata atgaaacatt cctctaatac acaaggctca gcttttccca actatattct
     3961 gtgtttgtat aggtatttca ccctttgttc aaaaaatgca gccactgaaa cttaagtcat
     4021 tgcactttta aacagtttga caatatcatg agtaatctgc ttaagatttg gtgtatttcc
     4081 taactgttga acacttaagt aactgagatg agaaaataag cattcatgag tagggatgta
     4141 gctcagttgc tggaatgctt acccaacatg catgcaaaat gggttccatc cccagtacca
     4201 caggaactgg gtatagtggt gcatgcctgt catcctaagc acttgggagg tggaggcagg
     4261 agaatcagaa gttcaaggcc atcctcatta cctggtgagt tgaggccagc ctgatatgct
     4321 gactcagata gaaatggctc tgttggtagt tattaggtcc tagccaagca ctgtcatttt
     4381 catctggaac atacaatgat gatgtattta tgatgtattc tcactaaggt tcacaatctg
     4441 taactcagtt caacacagat ctcttgagct ttaaaaggta tttgaagtaa tttaagtagg
     4501 cattcaaaat tatgaattag atgtttttaa atttctgcat aataattttg cactgtaaaa
     4561 tatgtccttt ctcccatttc cttctgccat tctgatatgc tcattaaaat atttttgtaa
     4621 gcatactca
//
LOCUS       NM_001436837            3597 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 7, mRNA.
ACCESSION   NM_001436837 XM_039110051
VERSION     NM_001436837.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3597)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039110051.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.20885.1,
                                           SRR26643297.20639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1623           JAXUCZ010000005.1  152852539-152852659 c
            1624-1749           JAXUCZ010000005.1  152850411-152850536 c
            1750-2211           JAXUCZ010000005.1  152847583-152848044 c
            2212-2407           JAXUCZ010000005.1  152846792-152846987 c
            2408-2617           JAXUCZ010000005.1  152844978-152845187 c
            2618-3597           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3597
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2725
                     /gene="Srrm1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 7"
                     /protein_id="NP_001423766.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSEDERPKRSHVKNGEVG
                     RRRRHSPSRSASPSPRKRQKETSPRRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRR
                     SPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSP
                     PPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPR
                     PRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRR
                     VSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQ
                     EGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEP
                     AAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    1220..>2227
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1220..>2227
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    <1826..2413
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1826..2413
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1623
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1749
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2211
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2407
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2617
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..3597
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgaagatgag cggcccaaga gatcccatgt gaagaatggt gaggtaggca ggcggcggag
     1561 acattctcct tctcggagtg cctctccatc acctcgaaag cgccaaaaag agacttcccc
     1621 tcgtagaagg aggagaagtc cttccccacc tcctgccaga agacgacgat ctccttctcc
     1681 agcccctcct ccccctcctc ccccacctcc tcggcggcgc agatctccca ccccaccacc
     1741 acgacgaagg accccttctc ctcccccacg ccgccgctca ccgtctccaa gaagatactc
     1801 tcctcccatc cagaggagat actctccttc cccacctcca aagaggagaa ctgcctcgcc
     1861 cccaccccca cccaagcgaa gggcatcgcc atctcctcca ccaaagcgcc gggtttccca
     1921 ctctccacct cctaaacaaa gaagcccccc agtcaccaag agacgctcac cctccttatc
     1981 ttcaaagcat aggaaagggt cttccccagg ccgctccact cgggaggccc ggtcaccaca
     2041 accaaacaaa aggcactcgc cctcaccacg acctcgggcg cctcagacct caagccctcc
     2101 ccctgttcga agaggagctt cagcgtctcc ccaaggaagg cagtccccgt ctccgagtac
     2161 taggcctatt aggagagtct ccaggactcc ggaacccaaa aagataaaaa aggctgcctc
     2221 accaagccct cagtccgtaa gaagggtttc atcttcccgc tctgtctctg gatctcctga
     2281 gccaacagct aaaaagcctc cagcaccccc ctctcctgtg cagtctcagt caccctccac
     2341 aaactggtca cctgcagcac cagccaagaa ggctaaaagc ccaacaccaa gcccgtcccc
     2401 tgccaggaat tctgatcaag aaggaggtgg aaagaagaag aagaagaaga aggacaagaa
     2461 acataagaag gataagaaac acaagaagca caaaaaacac aagaaggaga aggctgtggc
     2521 cgtagccacc ccagctcctg ctgcccctgc agctgtctct gctgccgcca ctccatcagc
     2581 ccaggaagag cctgcggcag caccagagcc caggaaggag actgagagtg aagctgaaga
     2641 tgacaacctt gatgacttag agaggcacct tcgggagaag gcccttcgat ccatgcggaa
     2701 ggcccaagtg tccccacagt cctaggcgga catgtttgtt acgttgtaaa ttttatttgg
     2761 tttgtactca attcaatttc aaaattgcta aaatgtgttt gagctttaga ctataacatt
     2821 tgttgtaata attgctaggt tgaagttcac catgttaaaa aaggggggca tggatttaca
     2881 ttacaaaggt gtccacggtg tattagtgac aattcttcca ttgacattta gagtgaaata
     2941 ttttaagcca aaaaaaaatc tcttttttaa aaaagggggt ttgaatattg ttggcatttt
     3001 tgtggttcct ttaaatgccc tcgcctctcc caaaaggttg gggtcttttc tttttctccc
     3061 tattctcttg aatcttagca cccatgtaaa ttatgcttcc aaccttgtat aggtttgtaa
     3121 gcttgcccag aagtgagagc actgttgaag taccacagag gtttgggcga gtgagtgttg
     3181 actctgttgc ccatggagtc tgctgtcctg gcagcatccc agctctagag cgccgcactc
     3241 ctgagctaca gggctgcccc atggaacagt tcctaaactg actaggaact ctgggttttc
     3301 tccttccggt tgtgttgttt tgtttccttc tccccttttc ttcctctttt gtaaaggcga
     3361 ttcactagac ccaggaagga cccttcagtt acataaattt gttttatgaa acatggtggc
     3421 tcccattcat ggtttccctt actcttccaa ttggtacaca caactgagga gctcctgtat
     3481 ttggccggct ggaagggcct ggacagtgtc ttgatttcac ttgttttatt ttattttatt
     3541 ttttaactaa agctatataa agcttgtgga ttaaacagaa taaatttcta aatttaa
//
LOCUS       NM_001107986            3624 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 4, mRNA.
ACCESSION   NM_001107986 XM_001069368 XM_233556
VERSION     NM_001107986.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3624)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3624)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3624)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3624)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3624)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107986.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166715.1, SRR26643287.14617.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1647           JAXUCZ010000005.1  152852539-152852683 c
            1648-1776           JAXUCZ010000005.1  152850411-152850539 c
            1777-2238           JAXUCZ010000005.1  152847583-152848044 c
            2239-2434           JAXUCZ010000005.1  152846792-152846987 c
            2435-2644           JAXUCZ010000005.1  152844978-152845187 c
            2645-3624           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3624
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2752
                     /gene="Srrm1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 4"
                     /protein_id="NP_001101456.2"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRS
                     HVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRSRRRRSPSPPPARRRRSPSPAPPPP
                     PPPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPP
                     PKRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQP
                     NKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAA
                     SPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPS
                     PSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAA
                     ATPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1190..2452
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1190..2452
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1853..>2443
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1853..>2443
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1647
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1776
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2238
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2434
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2644
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..3624
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgactctggc tcctcttcca cctcagaaga tgagcggccc aagagatccc atgtgaagaa
     1561 tggtgaggta ggcaggcggc ggagacattc tccttctcgg agtgcctctc catcacctcg
     1621 aaagcgccaa aaagagactt cccctcgtag tagaaggagg agaagtcctt ccccacctcc
     1681 tgccagaaga cgacgatctc cttctccagc ccctcctccc cctcctcccc cacctcctcg
     1741 gcggcgcaga tctcccaccc caccaccacg acgaaggacc ccttctcctc ccccacgccg
     1801 ccgctcaccg tctccaagaa gatactctcc tcccatccag aggagatact ctccttcccc
     1861 acctccaaag aggagaactg cctcgccccc acccccaccc aagcgaaggg catcgccatc
     1921 tcctccacca aagcgccggg tttcccactc tccacctcct aaacaaagaa gccccccagt
     1981 caccaagaga cgctcaccct ccttatcttc aaagcatagg aaagggtctt ccccaggccg
     2041 ctccactcgg gaggcccggt caccacaacc aaacaaaagg cactcgccct caccacgacc
     2101 tcgggcgcct cagacctcaa gccctccccc tgttcgaaga ggagcttcag cgtctcccca
     2161 aggaaggcag tccccgtctc cgagtactag gcctattagg agagtctcca ggactccgga
     2221 acccaaaaag ataaaaaagg ctgcctcacc aagccctcag tccgtaagaa gggtttcatc
     2281 ttcccgctct gtctctggat ctcctgagcc aacagctaaa aagcctccag cacccccctc
     2341 tcctgtgcag tctcagtcac cctccacaaa ctggtcacct gcagcaccag ccaagaaggc
     2401 taaaagccca acaccaagcc cgtcccctgc caggaattct gatcaagaag gaggtggaaa
     2461 gaagaagaag aagaagaagg acaagaaaca taagaaggat aagaaacaca agaagcacaa
     2521 aaaacacaag aaggagaagg ctgtggccgt agccacccca gctcctgctg cccctgcagc
     2581 tgtctctgct gccgccactc catcagccca ggaagagcct gcggcagcac cagagcccag
     2641 gaaggagact gagagtgaag ctgaagatga caaccttgat gacttagaga ggcaccttcg
     2701 ggagaaggcc cttcgatcca tgcggaaggc ccaagtgtcc ccacagtcct aggcggacat
     2761 gtttgttacg ttgtaaattt tatttggttt gtactcaatt caatttcaaa attgctaaaa
     2821 tgtgtttgag ctttagacta taacatttgt tgtaataatt gctaggttga agttcaccat
     2881 gttaaaaaag gggggcatgg atttacatta caaaggtgtc cacggtgtat tagtgacaat
     2941 tcttccattg acatttagag tgaaatattt taagccaaaa aaaaatctct tttttaaaaa
     3001 agggggtttg aatattgttg gcatttttgt ggttccttta aatgccctcg cctctcccaa
     3061 aaggttgggg tcttttcttt ttctccctat tctcttgaat cttagcaccc atgtaaatta
     3121 tgcttccaac cttgtatagg tttgtaagct tgcccagaag tgagagcact gttgaagtac
     3181 cacagaggtt tgggcgagtg agtgttgact ctgttgccca tggagtctgc tgtcctggca
     3241 gcatcccagc tctagagcgc cgcactcctg agctacaggg ctgccccatg gaacagttcc
     3301 taaactgact aggaactctg ggttttctcc ttccggttgt gttgttttgt ttccttctcc
     3361 ccttttcttc ctcttttgta aaggcgattc actagaccca ggaaggaccc ttcagttaca
     3421 taaatttgtt ttatgaaaca tggtggctcc cattcatggt ttcccttact cttccaattg
     3481 gtacacacaa ctgaggagct cctgtatttg gccggctgga agggcctgga cagtgtcttg
     3541 atttcacttg ttttatttta ttttattttt taactaaagc tatataaagc ttgtggatta
     3601 aacagaataa atttctaaat ttaa
//
LOCUS       NM_001436812            5119 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 7, mRNA.
ACCESSION   NM_001436812
VERSION     NM_001436812.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5119)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 5119)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2088701.1,
                                           SRR26643293.74877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000016.1  52858368-52858535   c
            169-621             JAXUCZ010000016.1  52856986-52857438   c
            622-1718            JAXUCZ010000016.1  52848306-52849402   c
            1719-1987           JAXUCZ010000016.1  52836572-52836840   c
            1988-2138           JAXUCZ010000016.1  52822585-52822735   c
            2139-5119           JAXUCZ010000016.1  52818691-52821671   c
FEATURES             Location/Qualifiers
     source          1..5119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..5119
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..168
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    137..139
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="upstream in-frame stop codon"
     exon            169..621
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2266
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 4 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 4"
                     /protein_id="NP_001423741.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MSKPTAASWLYEQVMPWTAGRPWRSPFHEPPSLLEALPRSCRPY
                     SAGLITVTGSLGTMDDRSAARTIFGRDSVPRSPRLSPSAESLPRSFRPRSRVRESPLA
                     SNAWEGEMWCGCACAERTRTRTLGAARESVAATVPRYTFGIMDRFGDISEGEVDHSFF
                     DSDFEDTKKCESNSIFDKQNDDDFKEGINKDIKNLNLKFGVQNDNLKEKIDNDTENVN
                     VKLGIQTKENYLTQKGNERKPKFPSKEQHVENDPIQTRSPSLLTSSRSKKLCDTTKGN
                     KLHLPVPNRIPKIVKGEDDYYTDGEESSDDGKKYHVRSKSAKPSSNLKKNNTSKKYSK
                     ASSSSLSSSSSRSSSDCSDIGSDMQNKPDSGSSGKRVSSVTPSSPKQKCKSGRKSSAK
                     QKAGDYNAESEDNVTDVTPASTPDSSPAQPFELSQSQNQKVKVKRQENVSRDVYEDVE
                     ALKNDSRCLKSAKRKEKHGQNFAPKSSVLDANLDRRSKQKVLHDTMDLNHLLKAFLQL
                     DKKGPQKHHFEQPSIIPRKNYSFTREEVRQIDRENQRLLKELSRQAEKPGNKSTIPGR
                     SLGHPPKLYHSALNRQREQQRIERENMALLKRLEAVKPTVGMKRSEQLMDYHRNISYL
                     NPSPSVRRVRSTLGHYSPLRGASRTSSATSGLSCKTDRSVLDTSSGFLLRPKPPNVRT
                     AWL"
     misc_feature    1700..2008
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1700..2008
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            622..1718
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1987
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2138
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..5119
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattagcagg cagtgaaagg caggaggtgg ggcctaggtg gaagaaggtc actagaggta
       61 tcgctataga ggttggcctg gcctcttcat gtaggccaga ttctccaacc ttacaattac
      121 atgaactgct gctctgtagt gccatgaagg actgaaccct ctaaaaataa ttacaagatt
      181 acagcatctt tgtaggaaac catcccagat gtctaaacct accgcagcgt cgtggctgta
      241 cgagcaggtg atgccctgga cagcagggag gccctggcgg tctcctttcc acgagccccc
      301 aagtcttctc gaggccctgc cgagaagctg tcgcccctac agtgcaggcc tcatcactgt
      361 gacggggtct cttggaacta tggacgacag gagcgctgcc aggaccatct tcggcagaga
      421 ctccgttccg cgatcgcccc gcctttcccc ttccgctgag tctctcccca ggagcttccg
      481 cccgcgctca cgtgtgcgcg agtctccgct agcttccaac gcgtgggagg gagaaatgtg
      541 gtgtggctgc gcgtgcgcag agcgaacgag aacccgaacg ctcggcgcgg cgcgagagtc
      601 ggtagcggcc acagttccca gatatacttt tggcatcatg gatcggtttg gcgatatctc
      661 agaaggtgaa gtggaccatt ctttctttga cagtgatttt gaagacacaa agaaatgtga
      721 aagtaattcc atttttgaca agcaaaatga tgatgacttt aaggaaggaa taaataagga
      781 catcaaaaat ttaaacttga aatttggagt acaaaatgat aaccttaaag agaaaataga
      841 taatgacaca gaaaatgtga acgtgaaact tgggatacaa acaaaggaaa attaccttac
      901 tcagaaggga aatgaaagga aaccaaaatt tccctcaaag gaacaacatg tagaaaatga
      961 ccctatacaa acaagaagtc cctcattgtt gacttcttca aggtcaaaaa aactgtgtga
     1021 taccacaaaa ggaaataaac tacatttgcc tgttccaaat agaattccta aaattgtgaa
     1081 aggtgaggat gactactaca cagatggaga ggaaagcagt gacgatggga agaagtacca
     1141 cgtgaggtct aagtcagcga agccctctag taacttaaaa aagaacaaca caagtaagaa
     1201 gtattccaaa gccagttcct cctctctgtc ttcctcatct tcacgatcaa gctcagactg
     1261 ctcagatata ggatctgaca tgcaaaataa acctgattca ggttcatcag ggaaacgagt
     1321 ttctagtgta accccctcat caccaaagca gaagtgtaag tcaggaagaa aatcaagtgc
     1381 taaacagaag gcaggtgact ataatgcaga gtcagaagac aacgtaacag acgtaactcc
     1441 cgcgtcaact ccagacagca gccctgccca gccatttgag ttgagccaat cacagaatca
     1501 aaaagtaaaa gttaaaagac aagaaaatgt gagccgggat gtgtatgagg atgtggaggc
     1561 tttaaagaat gattcaagat gtctgaaatc agccaaaagg aaagaaaagc atggacagaa
     1621 ttttgctcca aaatcatcag tgttagatgc aaatctagac cgtagatcca agcaaaaagt
     1681 cttacatgac acaatggacc ttaatcatct gttgaaagct ttcctgcagt tagataaaaa
     1741 gggaccacag aaacatcact ttgagcagcc ttcaataata cctaggaaaa actactcttt
     1801 cacaagagaa gaggtgagac agattgatcg ggagaatcag aggcttttga aagaactgtc
     1861 aagacaggct gaaaaaccag gaaacaaaag tacaattcct ggaagatcgc tcggccatcc
     1921 acctaagttg tatcacagtg ctctcaacag acagagggaa cagcaaagga ttgaaagaga
     1981 aaatatggct ttattgaaac ggcttgaagc tgtgaagcca acagttggca tgaaacgctc
     2041 tgaacagctg atggactacc atcggaatat cagttacctc aacccttcac cgtccgtcag
     2101 acgagtgaga tctactcttg gccattacag cccactgaga ggagcttcca ggacatccag
     2161 tgcaaccagt ggtctcagtt gtaagactga tcgatcagtg ttggacacat ccagtggctt
     2221 tttgctaaga ccgaaacccc cgaatgttcg tactgcttgg ttgtaaaacc tttttttatg
     2281 atatacattg ttcatctgtt ggtcctgttt taacgatgta tttttctgta ctactataac
     2341 tatttgcaaa catctgtcat acttttccaa caatttatac agcaatgagt ataatttatt
     2401 gttattcagt gcaaattgtt atcaaaagac actttgatgt aaaatcagtg tttcatgcag
     2461 tggcatattt ataggagcca tatgtctatt tcatagagaa aggtgtatgc atgaatgttt
     2521 cttcgatata ggaattcagc tgttgtgctg acaaagcagc agtggtggta atccatgttg
     2581 aaaccaagac gctcactata tagttcttaa tctatatgag tttcagttat tgtaagcgtt
     2641 aaggtgcttt accttgtaaa cttaagcgcc tcatgcttct gtctgcttta gactgtctgt
     2701 aacacgagtc agcacttgct tatgtgagtg ttccactcca aatgaaaaaa acttgaaatt
     2761 tgttttcatg gagaagctgg tgtagtcttg atgaggagca tgagcagctt gtatcagtgc
     2821 agctcttgct tgactaacga cgcttctccc taagtctgat tatctattcc aaaccgtttc
     2881 accccatgaa tgaggggttc actttagaag cgtctgtttc atgtttatat gcagtctggt
     2941 aaaataccct taaggattct gaggcaagag agaggcttta acagcttcga gtcttgtgac
     3001 ttgtgactgg tttggatcca gatcatttgc atcattaaca aaagcatgtg tttatggatc
     3061 agggagcaac attcccagct tgaagaccag ggtgtgttag agcagtgttt gaaatgatac
     3121 tgttagtgtg tgtgctgtcg ttgtgtattt attgtattaa tagaatgctt agagtaagga
     3181 agaaatgatt agagaaacca aatacaaaca agaaagaaac taatcacaca ttggtcacag
     3241 ctactgcctt aatgttagtg aatgtccttg gcttgcttta gctgagtcct ggaagcacca
     3301 gtcttcagtc tcatgtttga aggtctgtta atcctcatgg acttgctagt gacccacaga
     3361 tgtgaaatag ttgactatga aaaactagaa tattttcctg tcaacctaga ggctgttctt
     3421 ttgtagaaca aagtgtgtga tatttcatag tcatagcctt tcattgctgg tcttgtcagt
     3481 atgcctttag taaatacctt ttatattcaa tgacacgctt ttcttaaaat atgaattttc
     3541 cctgaccaca gagagatctg tctggttcag tgctcagcac tggagcatgt gggccacacc
     3601 tgcttcgcct tccgtagcag ggaggccgac tgcccttacc aagcaccagg tcacacattg
     3661 ttagtctcac tttaatggat ggtgttccag atagagcagt gatggtagga aatggtgaga
     3721 ccacaacaat gctgatatac atagcataca cacacataca ctctctctct ctctctctct
     3781 ctctctctct ctctctctct ctctctctct ctctcacaca cacacacaca cacacacaca
     3841 cacacacaca cacacacaca cacacgacta agggtttttc tgctgctttt ggaggactgt
     3901 aacattctat aacaatttat ttctttgttt tagtgaacaa gattttgtac ctgctctata
     3961 tacccctttt aatgtttttg taacaactta aatttaaaat gcaacatttt ggcatttgct
     4021 cagtagtgaa tcactttaaa gcagattttt gtgggaaaaa aacttgtata tgtaaaacct
     4081 tctatgttca cagtggcatt agcctaggca catttttgtt ggtctctcca agttccatag
     4141 ataaactaga atttgatttt aaatgctaat ttatgtctta gtttttactg tttggaagaa
     4201 gtttaactaa gtgttactga tgacaaggat tcaacctcaa gtaaagggca accatctttt
     4261 aaaagcaatt tagcttgtta tattgtaggt gcatagatct ggtgactgta gagatgggta
     4321 ggagttatac tcagaactca ctgatggacg tcaaggtact gttaggtagg attaggaagc
     4381 ctttgcaatg gaggagtcat gagtacatta atctcttcag cctcaccaac acaaacatgt
     4441 actcttagca ctgttgcatg gttggctggc tggtccttac caagcatact tggaaggccc
     4501 acatctgtag ctagaaagcg tgctggtctg ctgcctagag acagatctga gaactgtttt
     4561 catctctgtc aaatgttatc tccttttcta gtaagttttt gtgagatttc aaattattaa
     4621 aattacttct taaggagtag ctactacctc atcctcccca actgactctt tcagtcccca
     4681 tcaaaacctg ctctaactgc tattccagtt aacactctat ggcttgcttg tttaataaca
     4741 tcatgcactt gtgctcaacc caagtatcag aaacgcgact cgcggctttg agaggtgatt
     4801 gtgataggtc tgcttctcat ctgcagatac aatgcagcaa ctccaaagta ttaagatcac
     4861 actaagctga agatgcacct ttgccctggt tagcaacgca aaaccgtatc gtcatacatg
     4921 ccaaggcctt agcgtgtaga tgtctgtaca ccggcacagc gaatgagctc actgctaatg
     4981 gctgagttgc ttattttcat gaacaaagat tagcaagaaa ctgttaaacc atctttttaa
     5041 aaactgttct agtttgtcat attttaggca tgaagaacta gcttggctta ctgaagaaat
     5101 aaaagattta aagagaacc
//
LOCUS       NM_001436801            1481 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 7, mRNA.
ACCESSION   NM_001436801 XM_063287698
VERSION     NM_001436801.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287698.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.22214.1,
                                           SRR26643294.21731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  123105380-123105468
            90-190              JAXUCZ010000005.1  123106498-123106598
            191-215             JAXUCZ010000005.1  123118303-123118327
            216-361             JAXUCZ010000005.1  123122432-123122577
            362-523             JAXUCZ010000005.1  123130554-123130715
            524-656             JAXUCZ010000005.1  123131303-123131435
            657-721             JAXUCZ010000005.1  123132010-123132074
            722-794             JAXUCZ010000005.1  123134055-123134127
            795-946             JAXUCZ010000005.1  123138897-123139048
            947-1028            JAXUCZ010000005.1  123139751-123139832
            1029-1123           JAXUCZ010000005.1  123141269-123141363
            1124-1251           JAXUCZ010000005.1  123146672-123146799
            1252-1481           JAXUCZ010000005.1  123149294-123149523
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1481
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..89
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1315
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform f is encoded by transcript variant 7;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform f"
                     /protein_id="NP_001423730.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MDGASPGGGGSSGGGGSGGGYGVVARFSQCLAEFRTWLRTNWLR
                     FNADKTDVMLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNF
                     SSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGC
                     SGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESE
                     EDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVI
                     VFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAARE
                     ELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQ
                     QTRFGKKKYNLHPGVTMKRICPCCPQPLRAPLQGRD"
     misc_feature    725..874
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    725..874
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1043..1177
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1043..1177
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1043..1045,1133..1138,1142..1147,1151..1159,
                     1163..1171)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1043..1045,1133..1138,1142..1147,1151..1159,
                     1163..1171)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1205..>1264
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1205..>1264
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            90..190
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            191..215
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            216..361
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            362..523
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            524..656
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            657..721
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            722..794
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            795..946
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1028
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1123
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1251
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1481
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgag tctcccggct gcaggcggat ggatggggcg tctccaggcg gcggcggcag
       61 cagcggaggc ggcggtagcg gcggcggcta tggtgtggtg gctcgattct cccagtgcct
      121 ggctgagttt cggacgtggt taagaaccaa ctggttgagg ttcaatgcag acaagacgga
      181 tgtgatgctg ccatctgttg agtcttcaag tccagggggc tcagcagcgt cagaggacca
      241 tgagtttgat ccgtcagctg acatgctggt tcatgatttt gatgatgagc gaacattaga
      301 agaagaagaa atgatggaag gagagacaaa cttcagttct gaaatagagg atcttgcgag
      361 ggaaggcgac atgccaatcg acgagcttct cagcctctat ggttatggca gcactgttca
      421 gttacctgaa gaggaggagg aggaggaaga agaggaggaa gaaggtgaag atgatgaaga
      481 tgcggacaat gatgacaaca gtggctgcag tggggaaaat aaagaagaga atataaagga
      541 ttcatcgggt caggaggatg aaactcagtc ttccaatgat gatccctcac agtctgttac
      601 ttcccaagat gctcaggaaa taatccgccc acgtcgatgt aaatattttg atacaaatag
      661 tgaaatagaa gaagaatctg aagaagatga agattatatt ccctcagaag actggaaaaa
      721 ggaaatcatg gtaggctcca tgtttcaagc tgagattcca gttggcgttt gtagatacaa
      781 agaaaatgaa aaagtgtatg aaaatgatga tcagcttctg tgggatccag aatatttacc
      841 agaagataaa gtgattgtct ttcttaagga tgcatctaga agaacagggg atgagaaagg
      901 tgtagaagca attcctgaag gatctcatat aaaagacaat gaacaggctt tatatgaatt
      961 ggttaaatgc agttttgata cagaagaagc cttgagaaga ctgagattta atgtcaaagc
     1021 agctcgagag gaattatctg tgtggacaga ggaagaatgt agaaattttg aacaagggct
     1081 gaaggcctat gggaaagatt ttcatctgat tcaggctaat aaagtccgaa caagatcagt
     1141 tggtgaatgt gtagcattct attacatgtg gaaaaagtct gagcgttatg atttctttgc
     1201 tcagcaaaca aggtttggaa aaaagaaata taatcttcat cctggtgtaa caatgaagcg
     1261 catttgccct tgctgcccac agcctctgag agctccacta caggggaggg attgagagcc
     1321 acattcacat tggagagctt gctattccga ataatactta aaactccagt tacctgaact
     1381 ccagcgcttt taactcctca attgttcgac ccgactttct tcctaagcat ttgggatttc
     1441 attgataaaa ataaagatga taatggctat ctgtcacagt a
//
LOCUS       NM_001436835            3621 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 5, mRNA.
ACCESSION   NM_001436835 XM_006239185
VERSION     NM_001436835.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3621)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3621)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3621)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3621)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3621)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3621)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006239185.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16603.1,
                                           SRR26643298.29591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1647           JAXUCZ010000005.1  152852539-152852683 c
            1648-1773           JAXUCZ010000005.1  152850411-152850536 c
            1774-2235           JAXUCZ010000005.1  152847583-152848044 c
            2236-2431           JAXUCZ010000005.1  152846792-152846987 c
            2432-2641           JAXUCZ010000005.1  152844978-152845187 c
            2642-3621           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3621
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2749
                     /gene="Srrm1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 5"
                     /protein_id="NP_001423764.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRS
                     HVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRRRRRSPSPPPARRRRSPSPAPPPPP
                     PPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPP
                     KRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPN
                     KRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAAS
                     PSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSP
                     SPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAA
                     TPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1190..2431
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1190..2431
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1850..2437
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1850..2437
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1647
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1773
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2235
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2431
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2641
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..3621
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgactctggc tcctcttcca cctcagaaga tgagcggccc aagagatccc atgtgaagaa
     1561 tggtgaggta ggcaggcggc ggagacattc tccttctcgg agtgcctctc catcacctcg
     1621 aaagcgccaa aaagagactt cccctcgtag aaggaggaga agtccttccc cacctcctgc
     1681 cagaagacga cgatctcctt ctccagcccc tcctccccct cctcccccac ctcctcggcg
     1741 gcgcagatct cccaccccac caccacgacg aaggacccct tctcctcccc cacgccgccg
     1801 ctcaccgtct ccaagaagat actctcctcc catccagagg agatactctc cttccccacc
     1861 tccaaagagg agaactgcct cgcccccacc cccacccaag cgaagggcat cgccatctcc
     1921 tccaccaaag cgccgggttt cccactctcc acctcctaaa caaagaagcc ccccagtcac
     1981 caagagacgc tcaccctcct tatcttcaaa gcataggaaa gggtcttccc caggccgctc
     2041 cactcgggag gcccggtcac cacaaccaaa caaaaggcac tcgccctcac cacgacctcg
     2101 ggcgcctcag acctcaagcc ctccccctgt tcgaagagga gcttcagcgt ctccccaagg
     2161 aaggcagtcc ccgtctccga gtactaggcc tattaggaga gtctccagga ctccggaacc
     2221 caaaaagata aaaaaggctg cctcaccaag ccctcagtcc gtaagaaggg tttcatcttc
     2281 ccgctctgtc tctggatctc ctgagccaac agctaaaaag cctccagcac ccccctctcc
     2341 tgtgcagtct cagtcaccct ccacaaactg gtcacctgca gcaccagcca agaaggctaa
     2401 aagcccaaca ccaagcccgt cccctgccag gaattctgat caagaaggag gtggaaagaa
     2461 gaagaagaag aagaaggaca agaaacataa gaaggataag aaacacaaga agcacaaaaa
     2521 acacaagaag gagaaggctg tggccgtagc caccccagct cctgctgccc ctgcagctgt
     2581 ctctgctgcc gccactccat cagcccagga agagcctgcg gcagcaccag agcccaggaa
     2641 ggagactgag agtgaagctg aagatgacaa ccttgatgac ttagagaggc accttcggga
     2701 gaaggccctt cgatccatgc ggaaggccca agtgtcccca cagtcctagg cggacatgtt
     2761 tgttacgttg taaattttat ttggtttgta ctcaattcaa tttcaaaatt gctaaaatgt
     2821 gtttgagctt tagactataa catttgttgt aataattgct aggttgaagt tcaccatgtt
     2881 aaaaaagggg ggcatggatt tacattacaa aggtgtccac ggtgtattag tgacaattct
     2941 tccattgaca tttagagtga aatattttaa gccaaaaaaa aatctctttt ttaaaaaagg
     3001 gggtttgaat attgttggca tttttgtggt tcctttaaat gccctcgcct ctcccaaaag
     3061 gttggggtct tttctttttc tccctattct cttgaatctt agcacccatg taaattatgc
     3121 ttccaacctt gtataggttt gtaagcttgc ccagaagtga gagcactgtt gaagtaccac
     3181 agaggtttgg gcgagtgagt gttgactctg ttgcccatgg agtctgctgt cctggcagca
     3241 tcccagctct agagcgccgc actcctgagc tacagggctg ccccatggaa cagttcctaa
     3301 actgactagg aactctgggt tttctccttc cggttgtgtt gttttgtttc cttctcccct
     3361 tttcttcctc ttttgtaaag gcgattcact agacccagga aggacccttc agttacataa
     3421 atttgtttta tgaaacatgg tggctcccat tcatggtttc ccttactctt ccaattggta
     3481 cacacaactg aggagctcct gtatttggcc ggctggaagg gcctggacag tgtcttgatt
     3541 tcacttgttt tattttattt tattttttaa ctaaagctat ataaagcttg tggattaaac
     3601 agaataaatt tctaaattta a
//
LOCUS       NM_001436841            3764 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 11, mRNA.
ACCESSION   NM_001436841
VERSION     NM_001436841.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.163883.1,
                                           SRR26360186.1469989.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000005.1  152875116-152875174 c
            60-149              JAXUCZ010000005.1  152870802-152870891 c
            150-272             JAXUCZ010000005.1  152870321-152870443 c
            273-402             JAXUCZ010000005.1  152869903-152870032 c
            403-573             JAXUCZ010000005.1  152868094-152868264 c
            574-689             JAXUCZ010000005.1  152867543-152867658 c
            690-893             JAXUCZ010000005.1  152866067-152866270 c
            894-1082            JAXUCZ010000005.1  152864590-152864778 c
            1083-1202           JAXUCZ010000005.1  152864177-152864296 c
            1203-1477           JAXUCZ010000005.1  152861132-152861406 c
            1478-1558           JAXUCZ010000005.1  152855768-152855848 c
            1559-1645           JAXUCZ010000005.1  152855321-152855407 c
            1646-1790           JAXUCZ010000005.1  152852539-152852683 c
            1791-1916           JAXUCZ010000005.1  152850411-152850536 c
            1917-2378           JAXUCZ010000005.1  152847583-152848044 c
            2379-2574           JAXUCZ010000005.1  152846792-152846987 c
            2575-2784           JAXUCZ010000005.1  152844978-152845187 c
            2785-3764           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3764
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..59
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..149
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..272
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..402
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    382..384
                     /gene="Srrm1"
                     /note="upstream in-frame stop codon"
     exon            403..573
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2892
                     /gene="Srrm1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 11"
                     /protein_id="NP_001423770.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELK
                     KEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRR
                     SSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKSPELPEPSVRMKDSSVQEATSTSD
                     ILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHR
                     SRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSS
                     SSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSSPATPPPKTRHSPTPQQ
                     SNRARKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAAD
                     SVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRK
                     RQKETSPRRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRRSPTPPPRRRTPSPPPRR
                     RSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSP
                     PVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPRPRAPQTSSPPPVRRGAS
                     ASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPTAKK
                     PPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHKK
                     DKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPRKETESEAEDD
                     NLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    <418..513
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <418..513
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1333..2574
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1333..2574
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1993..2580
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1993..2580
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            574..689
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..893
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1082
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1202
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1477
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1558
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1645
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1790
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1916
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2378
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2574
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2784
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3764
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggtggcc ggaaaatggc ggcgggaatg ggctagagcc gaacctcacc ggccgtctgg
       61 gaacaagtgc ggagcaggat aatcgattca gcaacaaaca gaagaaactc ctcaagcagc
      121 tgaaatttgc agaatgtcta gaaaaaaagg tggacatgag caaagtaaat ttggaggtta
      181 taaagccttg gataacaaaa agagtgactg agatccttgg attcgaagat gatgttgtga
      241 ttgagtttat attcaaccag ctggaagtga aggcctgaac caaaatggaa gttattcctt
      301 gcgtctgaag tatagcacca tcaccttatt aggtcacagc agagtgagtg tcccaatgtc
      361 gctctgaccc aactcccttg atgacgcagt gtgtgtttgg agaacccaga ttccaaaatg
      421 atgcaaatca acctgactgg atttttgaat gggaagaatg ctagagagtt catgggagaa
      481 ctgtggcctc tgctgttaag tgcacaagaa aatatcgccg gaatcccttc tgctttccta
      541 gagttgaaga aggaagagat aaagcagaga caaattgaac aagaaaaatt ggcgtctctg
      601 aaaaaacaag atgaagataa agataagagg gataaggaag aaaaagaaag cagcagagag
      661 aagagggagc ggtctcgcag cccaagaaga cgcaaatcca gatctccttc ccctagaaga
      721 cgatcttccc ctgtcaggag agagagaaag cgcagtcact ctcgatctcc ccgtcacaga
      781 accaagagcc ggagcccttc ccctgcccca gaaaagaagg agaaatctcc agagctccca
      841 gaaccatcag tgagaatgaa agactcttca gtacaagagg ccacatctac aagtgacatc
      901 ttgaaagctc ccaagcctga gcctgtacca gagcccaaag aaccatctcc agaaaaaaat
      961 tccaaaaagg aaaaggaaaa gactcgacca agatctcggt cacgttccaa atcacggtcc
     1021 cggactcgtt ctcggtcacc ttctcatacg agacccagac ggcgacatag atcccgatca
     1081 agatcatact ctcctagaag gcgaccaagc cccagacgac gaccatctcc ccgaagaaga
     1141 actccaccaa gacggatgcc tcctccacca cggcacagga ggagtaggtc tccagggaga
     1201 cgaaggagac gttcttccgc atcgctgtct ggaagtagct cgtcgtcctc ttcatctcgt
     1261 tcccggtcac cgccaaagaa gcctcccaag aggacatcca gccctcctcg gaaaactcgt
     1321 aggttatcac cttcggcaag tcctccgagg cgaaggcacc ggccgtcatc tccagcaact
     1381 ccgccaccca aaactcgcca ttccccaact ccccagcagt caaaccgtgc aagaaaaagt
     1441 cgtgtgtctg tgtctccagg aagaacctcg ggtaaagtga caaaacataa aggcactgag
     1501 aaaagagagt caccttctcc agcacccaag cctagaaaag tggagctgtc tgagtctgag
     1561 gaagacaaag gcagcaaaat ggctgcagct gattctgtgc agcagaggcg acaatataga
     1621 cgacagaacc agcagtcttc atctgactct ggctcctctt ccacctcaga agatgagcgg
     1681 cccaagagat cccatgtgaa gaatggtgag gtaggcaggc ggcggagaca ttctccttct
     1741 cggagtgcct ctccatcacc tcgaaagcgc caaaaagaga cttcccctcg tagaaggagg
     1801 agaagtcctt ccccacctcc tgccagaaga cgacgatctc cttctccagc ccctcctccc
     1861 cctcctcccc cacctcctcg gcggcgcaga tctcccaccc caccaccacg acgaaggacc
     1921 ccttctcctc ccccacgccg ccgctcaccg tctccaagaa gatactctcc tcccatccag
     1981 aggagatact ctccttcccc acctccaaag aggagaactg cctcgccccc acccccaccc
     2041 aagcgaaggg catcgccatc tcctccacca aagcgccggg tttcccactc tccacctcct
     2101 aaacaaagaa gccccccagt caccaagaga cgctcaccct ccttatcttc aaagcatagg
     2161 aaagggtctt ccccaggccg ctccactcgg gaggcccggt caccacaacc aaacaaaagg
     2221 cactcgccct caccacgacc tcgggcgcct cagacctcaa gccctccccc tgttcgaaga
     2281 ggagcttcag cgtctcccca aggaaggcag tccccgtctc cgagtactag gcctattagg
     2341 agagtctcca ggactccgga acccaaaaag ataaaaaagg ctgcctcacc aagccctcag
     2401 tccgtaagaa gggtttcatc ttcccgctct gtctctggat ctcctgagcc aacagctaaa
     2461 aagcctccag cacccccctc tcctgtgcag tctcagtcac cctccacaaa ctggtcacct
     2521 gcagcaccag ccaagaaggc taaaagccca acaccaagcc cgtcccctgc caggaattct
     2581 gatcaagaag gaggtggaaa gaagaagaag aagaagaagg acaagaaaca taagaaggat
     2641 aagaaacaca agaagcacaa aaaacacaag aaggagaagg ctgtggccgt agccacccca
     2701 gctcctgctg cccctgcagc tgtctctgct gccgccactc catcagccca ggaagagcct
     2761 gcggcagcac cagagcccag gaaggagact gagagtgaag ctgaagatga caaccttgat
     2821 gacttagaga ggcaccttcg ggagaaggcc cttcgatcca tgcggaaggc ccaagtgtcc
     2881 ccacagtcct aggcggacat gtttgttacg ttgtaaattt tatttggttt gtactcaatt
     2941 caatttcaaa attgctaaaa tgtgtttgag ctttagacta taacatttgt tgtaataatt
     3001 gctaggttga agttcaccat gttaaaaaag gggggcatgg atttacatta caaaggtgtc
     3061 cacggtgtat tagtgacaat tcttccattg acatttagag tgaaatattt taagccaaaa
     3121 aaaaatctct tttttaaaaa agggggtttg aatattgttg gcatttttgt ggttccttta
     3181 aatgccctcg cctctcccaa aaggttgggg tcttttcttt ttctccctat tctcttgaat
     3241 cttagcaccc atgtaaatta tgcttccaac cttgtatagg tttgtaagct tgcccagaag
     3301 tgagagcact gttgaagtac cacagaggtt tgggcgagtg agtgttgact ctgttgccca
     3361 tggagtctgc tgtcctggca gcatcccagc tctagagcgc cgcactcctg agctacaggg
     3421 ctgccccatg gaacagttcc taaactgact aggaactctg ggttttctcc ttccggttgt
     3481 gttgttttgt ttccttctcc ccttttcttc ctcttttgta aaggcgattc actagaccca
     3541 ggaaggaccc ttcagttaca taaatttgtt ttatgaaaca tggtggctcc cattcatggt
     3601 ttcccttact cttccaattg gtacacacaa ctgaggagct cctgtatttg gccggctgga
     3661 agggcctgga cagtgtcttg atttcacttg ttttatttta ttttattttt taactaaagc
     3721 tatataaagc ttgtggatta aacagaataa atttctaaat ttaa
//
LOCUS       NM_001436838            3576 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 8, mRNA.
ACCESSION   NM_001436838 XM_017593406
VERSION     NM_001436838.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3576)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3576)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3576)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3576)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3576)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3576)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017593406.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.20886.1,
                                           SRR26643296.16389.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-660             JAXUCZ010000005.1  152866067-152866180 c
            661-849             JAXUCZ010000005.1  152864590-152864778 c
            850-969             JAXUCZ010000005.1  152864177-152864296 c
            970-1244            JAXUCZ010000005.1  152861132-152861406 c
            1245-1325           JAXUCZ010000005.1  152855768-152855848 c
            1326-1412           JAXUCZ010000005.1  152855321-152855407 c
            1413-1557           JAXUCZ010000005.1  152852539-152852683 c
            1558-1599           JAXUCZ010000005.1  152852153-152852194 c
            1600-1728           JAXUCZ010000005.1  152850411-152850539 c
            1729-2190           JAXUCZ010000005.1  152847583-152848044 c
            2191-2386           JAXUCZ010000005.1  152846792-152846987 c
            2387-2596           JAXUCZ010000005.1  152844978-152845187 c
            2597-3576           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3576
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2704
                     /gene="Srrm1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 8"
                     /protein_id="NP_001423767.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRTKSRSPSPAPEKKEKSPELPEPSVRMKDSSVQEATSTSDILKAP
                     KPEPVPEPKEPSPEKNSKKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRS
                     YSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSSSSSSR
                     SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSSPATPPPKTRHSPTPQQSNRAR
                     KSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQR
                     RQYRRQNQQSSSDSGSSSTSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKET
                     SPRMQMGKRWQSPVTKSSRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRRRSPTPPPR
                     RRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVS
                     HSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSPRPRAPQTS
                     SPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSV
                     SGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKK
                     KKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPR
                     KETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1100..2386
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1100..2386
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..660
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..849
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..969
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1244
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1325
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1412
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1557
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1599
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1728
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..2190
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2386
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2596
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..3576
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagaacc aagagccgga gcccttcccc tgccccagaa aagaaggaga aatctccaga
      601 gctcccagaa ccatcagtga gaatgaaaga ctcttcagta caagaggcca catctacaag
      661 tgacatcttg aaagctccca agcctgagcc tgtaccagag cccaaagaac catctccaga
      721 aaaaaattcc aaaaaggaaa aggaaaagac tcgaccaaga tctcggtcac gttccaaatc
      781 acggtcccgg actcgttctc ggtcaccttc tcatacgaga cccagacggc gacatagatc
      841 ccgatcaaga tcatactctc ctagaaggcg accaagcccc agacgacgac catctccccg
      901 aagaagaact ccaccaagac ggatgcctcc tccaccacgg cacaggagga gtaggtctcc
      961 agggagacga aggagacgtt cttccgcatc gctgtctgga agtagctcgt cgtcctcttc
     1021 atctcgttcc cggtcaccgc caaagaagcc tcccaagagg acatccagcc ctcctcggaa
     1081 aactcgtagg ttatcacctt cggcaagtcc tccgaggcga aggcaccggc cgtcatctcc
     1141 agcaactccg ccacccaaaa ctcgccattc cccaactccc cagcagtcaa accgtgcaag
     1201 aaaaagtcgt gtgtctgtgt ctccaggaag aacctcgggt aaagtgacaa aacataaagg
     1261 cactgagaaa agagagtcac cttctccagc acccaagcct agaaaagtgg agctgtctga
     1321 gtctgaggaa gacaaaggca gcaaaatggc tgcagctgat tctgtgcagc agaggcgaca
     1381 atatagacga cagaaccagc agtcttcatc tgactctggc tcctcttcca cctcagaaga
     1441 tgagcggccc aagagatccc atgtgaagaa tggtgaggta ggcaggcggc ggagacattc
     1501 tccttctcgg agtgcctctc catcacctcg aaagcgccaa aaagagactt cccctcggat
     1561 gcagatggga aagcgatggc agtcgccagt gactaaaagt agtagaagga ggagaagtcc
     1621 ttccccacct cctgccagaa gacgacgatc tccttctcca gcccctcctc cccctcctcc
     1681 cccacctcct cggcggcgca gatctcccac cccaccacca cgacgaagga ccccttctcc
     1741 tcccccacgc cgccgctcac cgtctccaag aagatactct cctcccatcc agaggagata
     1801 ctctccttcc ccacctccaa agaggagaac tgcctcgccc ccacccccac ccaagcgaag
     1861 ggcatcgcca tctcctccac caaagcgccg ggtttcccac tctccacctc ctaaacaaag
     1921 aagcccccca gtcaccaaga gacgctcacc ctccttatct tcaaagcata ggaaagggtc
     1981 ttccccaggc cgctccactc gggaggcccg gtcaccacaa ccaaacaaaa ggcactcgcc
     2041 ctcaccacga cctcgggcgc ctcagacctc aagccctccc cctgttcgaa gaggagcttc
     2101 agcgtctccc caaggaaggc agtccccgtc tccgagtact aggcctatta ggagagtctc
     2161 caggactccg gaacccaaaa agataaaaaa ggctgcctca ccaagccctc agtccgtaag
     2221 aagggtttca tcttcccgct ctgtctctgg atctcctgag ccaacagcta aaaagcctcc
     2281 agcacccccc tctcctgtgc agtctcagtc accctccaca aactggtcac ctgcagcacc
     2341 agccaagaag gctaaaagcc caacaccaag cccgtcccct gccaggaatt ctgatcaaga
     2401 aggaggtgga aagaagaaga agaagaagaa ggacaagaaa cataagaagg ataagaaaca
     2461 caagaagcac aaaaaacaca agaaggagaa ggctgtggcc gtagccaccc cagctcctgc
     2521 tgcccctgca gctgtctctg ctgccgccac tccatcagcc caggaagagc ctgcggcagc
     2581 accagagccc aggaaggaga ctgagagtga agctgaagat gacaaccttg atgacttaga
     2641 gaggcacctt cgggagaagg cccttcgatc catgcggaag gcccaagtgt ccccacagtc
     2701 ctaggcggac atgtttgtta cgttgtaaat tttatttggt ttgtactcaa ttcaatttca
     2761 aaattgctaa aatgtgtttg agctttagac tataacattt gttgtaataa ttgctaggtt
     2821 gaagttcacc atgttaaaaa aggggggcat ggatttacat tacaaaggtg tccacggtgt
     2881 attagtgaca attcttccat tgacatttag agtgaaatat tttaagccaa aaaaaaatct
     2941 cttttttaaa aaagggggtt tgaatattgt tggcattttt gtggttcctt taaatgccct
     3001 cgcctctccc aaaaggttgg ggtcttttct ttttctccct attctcttga atcttagcac
     3061 ccatgtaaat tatgcttcca accttgtata ggtttgtaag cttgcccaga agtgagagca
     3121 ctgttgaagt accacagagg tttgggcgag tgagtgttga ctctgttgcc catggagtct
     3181 gctgtcctgg cagcatccca gctctagagc gccgcactcc tgagctacag ggctgcccca
     3241 tggaacagtt cctaaactga ctaggaactc tgggttttct ccttccggtt gtgttgtttt
     3301 gtttccttct ccccttttct tcctcttttg taaaggcgat tcactagacc caggaaggac
     3361 ccttcagtta cataaatttg ttttatgaaa catggtggct cccattcatg gtttccctta
     3421 ctcttccaat tggtacacac aactgaggag ctcctgtatt tggccggctg gaagggcctg
     3481 gacagtgtct tgatttcact tgttttattt tattttattt tttaactaaa gctatataaa
     3541 gcttgtggat taaacagaat aaatttctaa atttaa
//
LOCUS       NM_001134863           10394 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus storkhead box 2 (Stox2), transcript variant 2,
            mRNA.
ACCESSION   NM_001134863 NM_173107 XM_224852
VERSION     NM_001134863.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10394)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 10394)
  AUTHORS   Fenstad,M.H., Johnson,M.P., Loset,M., Mundal,S.B., Roten,L.T.,
            Eide,I.P., Bjorge,L., Sande,R.K., Johansson,A.K., Dyer,T.D.,
            Forsmo,S., Blangero,J., Moses,E.K. and Austgulen,R.
  TITLE     STOX2 but not STOX1 is differentially expressed in decidua from
            pre-eclamptic women: data from the Second Nord-Trondelag Health
            Study
  JOURNAL   Mol Hum Reprod 16 (12), 960-968 (2010)
   PUBMED   20643876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001134863.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2312063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1524              JAXUCZ010000016.1  51707212-51708735
            1525-1677           JAXUCZ010000016.1  51796410-51796562
            1678-3943           JAXUCZ010000016.1  51806139-51808404
            3944-10394          JAXUCZ010000016.1  51813459-51819909
FEATURES             Location/Qualifiers
     source          1..10394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..10394
                     /gene="Stox2"
                     /note="storkhead box 2"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
     exon            1..1524
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1317..1319
                     /gene="Stox2"
                     /note="upstream in-frame stop codon"
     CDS             1359..4139
                     /gene="Stox2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     knockout CG10573-PA related; storkhead-box protein 2;
                     spinelinin"
                     /codon_start=1
                     /product="storkhead-box protein 2 isoform 2"
                     /protein_id="NP_001128335.1"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
                     /translation="MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAF
                     APQASRGYMTSGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLT
                     TCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHL
                     DERVPDRSQCTSPQPGTITPSASGCVRERTLPRKHCDSCHCCREDMHSMHASTLQRKP
                     AKDCKDPYCPPPLCQVPPTDKSKSTINFSYKTETLSKPKDGEKQSKKFGLKLFRLSFK
                     KDKTKQLANFSAQFPPEEWPLRDEDTPTTIPREVEMEIIRRINPDLTVENVMRHTALM
                     KKLEEEKAHRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIP
                     GEREYEFCDPLTRAPREGCFIIEHKGDNFIMHSNTNVIESHFPMTPEWDVSGELAKRR
                     TEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSKGPLGASSLGT
                     PEDLAEGCSQDDQTASQSYIDDSTLRPAQTIGHQRAHIPSASYKEVCIPEIVGGSKEP
                     SSACSLLEPGKSPESMPSYGELSPCPAKTAVDDYFQCNTSSETVLTAPSPLGKNKEDH
                     DTLTLVEGVKKLSPSERQTPHSSRDPVGHKEESPKGPGGGPAASGGVAEGLANGRLVQ
                     HHSAEPSNLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKSPADTLPGRCE
                     KMEPSLGTSAAQAMPPSQRQQEPGGNQEASFDYYNVSDDDDSEEGANKNTEEEKNRDD
                     VGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDSMDSSSITVDS
                     GFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPTFNFRASTDPPTSEAEKLQK
                     PSNCLQASVTSV"
     misc_feature    1545..1781
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     misc_feature    1545..1781
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     exon            1525..1677
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3943
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..10394
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagctgtg cagggcccgg cggtgcagag gccccgggcc cgccagcgca gcaaggccac
       61 tggggagtga cttccactca ggatcgcgga gggcgcaggc cgttggcgcg tggcagtcgg
      121 cgtgggcctg gcgtccccgc gcgttcgcgg cgccccgtgt ctccggctgg gcgcaggtgg
      181 gccaggccgg gcgccgcaaa tcggcgcgtt cccacgaagg ctagccctcg gagcgagggg
      241 gagggaccat cggaaagacg tggaacgatc cgcgcggtgt catccgcagg gcccaggccc
      301 cgcgccaccg ccgccgtcgc cgccgccgtc gccgccgctg gggcttggct gcggggatcc
      361 acgcagagcc tccgcgcagc cccgagatta gcatgacact gggtagccat cccgcttccg
      421 gcggtgccag agcgcaacgc gctagtcccc gagccgcgat ggccccgcgc gggggccgat
      481 cgccgggctc cgcggccgcc gcggcccgtg agtaggagta tgcctgcggc gggggaccca
      541 cgcgtgtcgg cacgcgcccc caccctcccg cgcccccgcc agccttggaa ggaggaagcc
      601 tgacgccacg ccgcggtcgc cagcacccaa ccgggctctt cctgcgttgt cgcagcggcg
      661 gtcccggtgc tcccgcgcgc cccccgttcg agcctctgga atgaagactg actcccgagg
      721 actgcgagag agaagcagag gcagcgggcg ctggagactg cgggcctcgc ggctggaagg
      781 tccgggggga cgcgactcgg acgctgtcat ccccacgcct cgcgctgaag cctcctagtg
      841 cggttggggc tgccgcccac cggtcaagct gccggggcgt gcgacccggg gtcggccccc
      901 agaggcctcg gcttcctcat ttgtttgggt cttttgtgct gtggcgcaca gttggctaag
      961 cactcctgcg ctgaatcggg ccattgtctg cgctcccatt gcttccacgc tgcaagtctc
     1021 ggcgccccca ccccggccgc cccctcccgg acgccgagcc tcccaacgtg ccttcccccc
     1081 caggaatctg gaagctgaaa gcccggcgga ttgcaaatga agtggaatgc attgtgggac
     1141 gagtgtaaaa tccgagcctt ctccgtgggg gtgtgggggg gcgtggggag ggccggacct
     1201 gccgccggcg gtgtagacac cgaggagaag agggtctggg gaaaaaaaat gtgcgcagag
     1261 tcctcccggg tcgtggccgc ggtagacgga tgaagctgcg cgctgcgccc tggcgctgag
     1321 gccctactat tggggcacca gggtcgccct tccccaccat gaagaagacc cggagcacaa
     1381 ccttgcggcg agcctggcct agctcggatt tctcggaccg ggcctcggac cgcatgaggt
     1441 cccgcagcga gaaggactac cgcctgcaca agcgcttccc cgcggccttc gcgccccagg
     1501 cttctagggg ttacatgaca tcaggtgatg tgtcaccaat cagtatgtcc cccatcagtc
     1561 aatctcagtt tattccactc ggggaaatcc tttgcttggc catctcggca atgaactctg
     1621 cgagaaagcc tgtcacccag gaggcgctga tggaacacct gacgacgtgt ttcccaggtg
     1681 ttccaacccc aagccaagaa attctacggc ataccctaaa cacactggta cgggagagga
     1741 aaatctatcc gactccggat ggctatttca ttgtgacccc acagacttat ttcattactc
     1801 cttccctcat aagaactaac agtaagtggt accacttgga cgagagggta cctgacaggt
     1861 ctcagtgtac ctctccacaa ccaggaacca taacgccctc tgcctcaggc tgtgtcaggg
     1921 aaaggacatt acccagaaag cactgcgact cttgccactg ctgccgagaa gacatgcaca
     1981 gcatgcatgc ctccactctg cagaggaagc ccgccaagga ctgcaaagac ccttactgcc
     2041 ctcctccgct gtgccaggtg ccacccactg ataaaagcaa aagtactata aatttctctt
     2101 ataagacgga aactctctct aaacctaaag atggtgaaaa gcagtccaag aaattcggcc
     2161 ttaagttatt ccggctgagt tttaaaaaag acaagaccaa acagctggcc aatttctctg
     2221 cccagtttcc tcctgaggag tggcctctgc gagacgagga cacgcccacg actatccccc
     2281 gggaggtgga gatggagatc atccgtcgta tcaacccgga cttgacggtg gaaaatgtca
     2341 tgaggcacac tgcactgatg aagaaacttg aagaagaaaa agctcaccgg agcaaagccg
     2401 ggtcctccgc ccaccacagt ggaaggagta aaaagagccg gactcaccga aagtcccacg
     2461 ggaagtctcg gtcacacagc aagactcgag tgtccaaagg agatccttcg gatggctcgc
     2521 atctggatat ccctggtgag agggagtatg aattttgcga ccctctaacc agggccccca
     2581 gagagggctg cttcatcatt gaacacaaag gagacaactt catcatgcac agcaacacga
     2641 acgtgatcga gtcccatttc cccatgacgc cagaatggga tgtgtctggc gaactggcca
     2701 aaaggagaac ggagatgccc tttcccgaac cttccagggg aagctcccac tccaaagtgc
     2761 accgaagcca cagccatacc caggaccgga ggtccaggaa tgagaggtcc aacaaggcca
     2821 aggagagatc caggtcaatg gataactcca aaggccccct gggcgcttct tctctcggga
     2881 ctccggaaga cctggctgaa ggctgcagcc aagatgacca aacagccagc caatcataca
     2941 ttgacgacag tacgttaagg cctgcgcaaa cgattggtca tcaaagggct catattcctt
     3001 ctgccagcta taaagaggtg tgcattccag aaatagttgg tggcagcaag gaaccttcta
     3061 gtgcttgtag ccttttggag ccaggcaaat cccctgagag tatgccgtct tatggggaac
     3121 tcagcccttg cccggcaaaa acagctgtgg atgactattt tcagtgcaac acttctagtg
     3181 agactgtgct cacagcaccg tctcctttag ggaagaataa ggaggaccac gacactttga
     3241 ccttggtgga gggggtaaaa aagctgtctc catctgagag gcagaccccc cactcttcca
     3301 gggatcctgt tgggcacaag gaggagtcac caaaagggcc aggtgggggc cctgcagctt
     3361 ctggtggtgt ggcagagggg ttggccaatg gccgtcttgt ccaacatcat agtgcagaac
     3421 ccagcaactt ggacaaaagg aaagaaatat tcagcaaaga cacactgttc aaacctctac
     3481 acagcacctt gtctgtaaac agctatcaca aatccagctt gtccctcctc aaatctcacc
     3541 cgaagtcacc tgctgacaca ctgccaggcc gatgtgagaa aatggaacct tcccttggga
     3601 cgtctgcggc ccaagccatg cctccgtccc agcgtcagca ggagcctgga gggaaccagg
     3661 aggcctcctt tgactattac aacgtctccg acgacgacga ctctgaggaa ggggccaaca
     3721 aaaacacaga ggaggagaaa aacagagatg atgtgggcac catgcagtgg ctcctcgaga
     3781 gggagaagga aagagacttg cagaggaagt ttgagaagaa cctcaccctc ctcgccccaa
     3841 aggaaaccga tagcagcagc aaccagagag ccacccactc agcccggctc gacagcatgg
     3901 acagtagcag catcaccgtg gacagcggat tcaactcccc acgcactcgg gaaagcctgg
     3961 cttccaacac atcaagcatt gttgaaagca accgccgtca gaatcctgct ttgagtccgg
     4021 cccatggcgg agctggtcca accttcaact tccgcgccag tacggatccc ccgaccagcg
     4081 aagctgagaa attacagaaa ccttccaact gcttgcaagc ttctgttact agtgtatgat
     4141 tgtccttctg cctcagatct tctgtctcat tcgatacagc aacgtttacg acgattggga
     4201 ctgatgttta catctcttca aaggcaaaca tctcaagcac aggttggggg ttacttgagc
     4261 tgtgctgcta agtaggctag ggcaaaaaaa aaaatcttca tttcagagta ttgcttttca
     4321 catgtatggc tctgtagcta ccaaatagca gtatgggaga tacgtacact tccgcttcac
     4381 taattgtatc tgagcacaca taggaaagtc taaacactgt aagtggaaca tgcatttttc
     4441 gatgtcatac agttgccaat tccattctga aaatgccaca gagatgtgtt gctccctgcc
     4501 ggcctacggg gtacgggccg tgggactcat ccttgataac cccgccccct caaacccccg
     4561 ccccctcaaa aaaaagccaa gccgccacaa aatgtaaatg taggggtgtg tccattgtga
     4621 gaaaaaacag tgccaaactg ggcagaaggg accccagccc tttatgtgtg agtcctttaa
     4681 agtaccagtc atttttcact gtgagttttc acgacactct tgcaggagcc catggaagtg
     4741 ggtcagaggt cccaatggaa gttgttgggg tatttgtttt tactgttttc cagctcacta
     4801 aatgcttgtc ttgagttttt tgttttttta accttcccta atcacaaaca ggaatatagg
     4861 cctttgaggt ggacaaagga aaggaaatgc ggtctcatgg gggcacagca ctgagtgctg
     4921 gagaagggtg tgtggatgac caggagggat gaatcagata ctggagaagg atgcttccct
     4981 ccttgggaca cttaggatga tcgagctgac tatattagat gcggtgatta atctgttggg
     5041 aagtaaaatg ttctttatga tacaaatgaa gaatgtggcc cgagggtgtt attctttcta
     5101 atggaaggga cataaatcta ttttatgtag ttttaaatag aatgcctaaa ttaggctgtg
     5161 gagatgattt ttagtggttg taggaaaaga gcaaatttag ggagagttaa acttcaggcc
     5221 ttttattcct gggaagatat ctatagagac aacatttaaa gtaatttttg attagaaata
     5281 tacatgggcc catgtaatga acagcagaat gtcctcattc tgctggcgtg gtatattctt
     5341 aatttgtact cccctaaagt gtatcagaat gacacttatg cattcatgaa ctatgccaga
     5401 gtaatgttta cagatacttt gtagtgattt caggaggcgc cttttgggtg gacatcatct
     5461 ttgcaatgac ttctccaagc tctgctttgg tttaagacgt catgctcagt atcccaaggc
     5521 tttgcaggag ggggaccact aaccattaca cttcagtcct accagaaagg ctctcttcaa
     5581 aagtcccttg atcttatttt ctgagacgcg tggcatacct ctgtaggttc tgaaaatctt
     5641 atctgcacgt gggttaggtc tgatctcaga aaatggtctg aaacaaaatt acattcagtt
     5701 gagtgtcaaa tgatttttgg agccatatgc tttaatgaat ttatagataa ataacttaaa
     5761 aatcagtata aaatattttc actcaagatt tcagcaatga gcataagttt gtgagctact
     5821 tctttttctg tgtcaggctg aatcactagc aaggtgtcta agggagcaca gtcatatgaa
     5881 gcagttggaa acatgtacat tcattttgtc tgctatttgg aagttgtact attgggtcaa
     5941 actgggctcc ttaagcttgg tataaatttc tttttcttgc ttattgtaat gaagcttaag
     6001 cacagttctc agtatactgc tacattgttg aaatgcttaa gggaattggc ttcgaatccc
     6061 atactctact tcctcctggc atgcctcagt tgttcagaag cacattgttt ctctgattac
     6121 ttaagtaatg tccagaaaga gcaaccatgt atctgattac tacatagtct gtttgcttaa
     6181 ggagccgtac accataagat tcctggatct ggtctaaatc aatttgcccc ccccaccccg
     6241 cgccctaaaa aaacctgctc tgaaactttt ggcatactca gttcataaat aacagaactg
     6301 ttaaaacaat acactaatct ctgattgacc tctgaacata gtagccattg aaagaattga
     6361 gtgccgtgcg agcaggagag gacataatta tgttttaagc gaagctttaa aatatgcatt
     6421 tttgatagtt caccaaaaac aggtttacag aagacatttt ccaaacaaaa tgtgtacact
     6481 atttgcctaa tcactatgga gtacaagatt taaaaaaata ataagtggat aagcaaaaga
     6541 acttccctta gaccagcagc cattagcact gaacgatggg ctttaaagat gatgtaacac
     6601 atacacagac attccgtgga gaaacactct cgtctgaatc taatctggat tcttgaatgg
     6661 agaggcattg gtggtaggag gcacatggca gtgtgatgcg tacatgtgtc taagatggtc
     6721 tcctcaaaat ggtgagactc tttgactctc acagcctcga gactctctcc aggcttcgtc
     6781 agttttctcc actggaacca tagctctgtg ttctgtgacg gcatgtctag ttttagagtt
     6841 tatcaacgga aaggtttaca aaactgaatc tggttgaatc tctgtgaggc attcaacttt
     6901 aaagggtcaa cacatctgtc ggcattttgc acacgtatgt attattatga tacagcatat
     6961 tactttatgg taatttttat tttttacata taactacctc catgaatttg atgaaatggc
     7021 agcagtgtgt ttaagtgtgt tcttcagaaa aagcaatgtt gcaaacgtgt ttcagcggta
     7081 ggccatggcg tggcgtgtgt gtcggtgact tacccattgg actcatgacc ttttcattgc
     7141 cgtgattttc tttcacaaca ttctttggct cccaactgta agcctgttgt cctctttttc
     7201 tctctccctt ctcccccatg aaagcacatt tgatttgtta caaatgaacg aacattttaa
     7261 aattactgtc ttccctgctt ctacacgctc actattagag aaaaaaaaaa gtcttctctg
     7321 gcaaagagcc acttggtaaa catttaggaa gttattaatt cctatagaaa ttacattgaa
     7381 ttgttagggt gtttttttcc ccagtaacaa aagatatgtg aaaattttgg actgccaact
     7441 tgaagcactt tgggcctctc tgcctctatg ctaccctatg gagcccaaac ttttttttat
     7501 taaaagaact gtgccatgca ttctgagatg tctgttaagt aatttgtcta ccctttgatt
     7561 gcacatctca ggagacttta atgagtgcaa gaatagggtg tgtgtgcacc caatagagaa
     7621 aaccaatgtg agagctgaaa tgggagtagc cgggtagaaa taagaaatgc cggtgtcttt
     7681 gatgttggag aattcaagtt caggaaatat gaatggaaag agaatgtgga ggagcagtga
     7741 tttgaacacc agctgttcct aaatgtctct tttctgagaa ctcagccaat attgttacaa
     7801 tgtcaccaag acaggaaagg cagtaaggac agaagaacat agtttctctt ttaggttagc
     7861 atagctttgt aaagtcctac ctaggattat ccactggtca ccacaaagtg tacttgaaga
     7921 taaagtttgt aacttcagtg ataggcacag ttctcacaaa accatttggg aggggtagcg
     7981 ttctgagctt gcactaacaa ccaacgactg gtaatgttct gcagctcatc tggcgatctc
     8041 aaagtgcttc cgaggcatta ggcgtacaat tgcagggcag gtccagtttc tcatacccag
     8101 gcttgacagg agcaaacaaa tggagtgtct tgagatcacc cataaacaca atggcagctc
     8161 tcagtgacct attttctatc tgtttgatag gccatggtga gaaatcacta agatgctatt
     8221 tttatgatgt gtgctaataa agaaaacaaa tacagcttga caccttgtcc atttcattca
     8281 aagaggtatg ggtgtttgga atctcagcac ctcagcaccc cttactggta ttgagttatg
     8341 acgtgggaga ggagcaaatc cacaccaatg ccactgtcat ccaaagccag tccaggcatc
     8401 cacctttgtt tacagctcct tattaggtcc ctgtcatatc tgtgttaaaa caaaacccca
     8461 tctccaggaa cattggctgc tccaggcagt ggaaggtgct gaaacagttg tgtttttttt
     8521 ctcttaattt tcctttaaaa tattcatcaa gcactcctca cagtgttcag caacatacca
     8581 ctcactacgt tatatcaagc cctgcttcgt agaatctggg aagctgatcc agttccaaga
     8641 gttttgtcaa attatgagat agaaggtctt tgacttctgc tttctccttt cccacagacc
     8701 agacccacac ccaactagca gtgcagtgca gaccacagta gactcgaagt ggtgcttcct
     8761 cccccgaccc ccgaccccca tccattgtca aagccatcca ataatgtcct gtgagcgagg
     8821 gactctttgg cccgtgttta aggcttgggg aaattagaaa caagaaaaat gaatgcaaaa
     8881 agccatggga ggcattggtt tcctttgggc tagttaaaca tggtggcaag ggattgctat
     8941 tgtatgagct ttgccaagaa atacaaaaga ctcagccatc accccatcct tctcgaagaa
     9001 ggttttatag tattaatgat acaagtgata ttttcccatg gagttttcct taggatacat
     9061 ttcataaatt atacacatga gacattttag cattagatct catgtgtttg ccaaaggtac
     9121 tggcttctcc ctggcttgga gtccatcctc ttgtcttgca tcagcaacgc agaggggctc
     9181 ctcggtgatg gcttctagaa tacatatgcc tgtgtcttta ttgttgtgca caggcttaac
     9241 atttgcaaaa ttgagaattc ggcaaagctc caggggaact aagcggtctt gtgattgtat
     9301 gcaggcagtc agaggccttt aatggctcat tgtcggcttc acttgtgaac acatacaccc
     9361 tcccgactag gaaaagggtg tttccaggtg aggtaccaat ggcttggaaa ggcagaaatg
     9421 gaaggttaga gcttggctgg tccttgtgca cctgcctacc tccctgtcca aaggctgacc
     9481 ttggtacccg cccccccccc attccccttc tctcacccca aaagaggtac caaatctgag
     9541 acccgagctc tccttcaatc ccagtcctct acagctccag gaccttcata tagaacattc
     9601 tcgacagccc cgccttcctt tcctctgagc gttaccctct ccgcctcccc accaccacca
     9661 gatacctacc ccaccaccac tctttccaca ttggaagaac agaatactgt gtagtattgt
     9721 gcacgcatgc cagttaggag tagaactgcc ctagggtcac cttcacatca gtgtcaacag
     9781 ctacaaacat aaagtcctta gagcagtcac atccatactc tctggaagag aattcaattt
     9841 gaccatctaa gttccaaggg atcgtggctc tgcgggcgtc tttctctgtg tggctgactg
     9901 tgactattac attagggtca gtgagctaag aagtacgtgt gggattcact gtgttaggaa
     9961 ggagttttgc agccaagact gccttgaata aaaatgtttt tgcactgaaa aaaaaaaact
    10021 ttaaatgact tggtctctgg ttgctgtaaa ggtcatccaa gatggatgtt ctgtttatat
    10081 tgtatagtat ttcataagaa ataactgcag ttcatgaaac gtcttcccta atgttactga
    10141 tttctaacag cacatttgta acatggtttt tatcgtgtcc gtgtaccata ctgtaaatga
    10201 tgattccttg tcatgcttag tataataagt taaaaggaaa aaaaaaaagg acagggattt
    10261 ttgtaagtct atatttgaaa gtccctccat atggtaatat tgtgttcatg ttgtttatgt
    10321 agtgttgtgt gaaatatcca ttttggattg tgttactttt taagatatta aataacattt
    10381 ggttatatgt gtaa
//
LOCUS       NM_001436817            9174 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus storkhead box 2 (Stox2), transcript variant 3,
            mRNA.
ACCESSION   NM_001436817 XM_039094520
VERSION     NM_001436817.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9174)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 9174)
  AUTHORS   Fenstad,M.H., Johnson,M.P., Loset,M., Mundal,S.B., Roten,L.T.,
            Eide,I.P., Bjorge,L., Sande,R.K., Johansson,A.K., Dyer,T.D.,
            Forsmo,S., Blangero,J., Moses,E.K. and Austgulen,R.
  TITLE     STOX2 but not STOX1 is differentially expressed in decidua from
            pre-eclamptic women: data from the Second Nord-Trondelag Health
            Study
  JOURNAL   Mol Hum Reprod 16 (12), 960-968 (2010)
   PUBMED   20643876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039094520.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1395442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000016.1  51779138-51779441
            305-457             JAXUCZ010000016.1  51796410-51796562
            458-2723            JAXUCZ010000016.1  51806139-51808404
            2724-9174           JAXUCZ010000016.1  51813459-51819909
FEATURES             Location/Qualifiers
     source          1..9174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..9174
                     /gene="Stox2"
                     /note="storkhead box 2"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
     exon            1..304
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    226..228
                     /gene="Stox2"
                     /note="upstream in-frame stop codon"
     CDS             235..2919
                     /gene="Stox2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     knockout CG10573-PA related; storkhead-box protein 2;
                     spinelinin"
                     /codon_start=1
                     /product="storkhead-box protein 2 isoform 3"
                     /protein_id="NP_001423746.1"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
                     /translation="MRKELSMYWKGNSQPSHVLKSTKGDVSPISMSPISQSQFIPLGE
                     ILCLAISAMNSARKPVTQEALMEHLTTCFPGVPTPSQEILRHTLNTLVRERKIYPTPD
                     GYFIVTPQTYFITPSLIRTNSKWYHLDERVPDRSQCTSPQPGTITPSASGCVRERTLP
                     RKHCDSCHCCREDMHSMHASTLQRKPAKDCKDPYCPPPLCQVPPTDKSKSTINFSYKT
                     ETLSKPKDGEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDEDTPTTIPR
                     EVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAHRSKAGSSAHHSGRSKKSRTHRKS
                     HGKSRSHSKTRVSKGDPSDGSHLDIPGEREYEFCDPLTRAPREGCFIIEHKGDNFIMH
                     SNTNVIESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNE
                     RSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTASQSYIDDSTLRPAQTIG
                     HQRAHIPSASYKEVCIPEIVGGSKEPSSACSLLEPGKSPESMPSYGELSPCPAKTAVD
                     DYFQCNTSSETVLTAPSPLGKNKEDHDTLTLVEGVKKLSPSERQTPHSSRDPVGHKEE
                     SPKGPGGGPAASGGVAEGLANGRLVQHHSAEPSNLDKRKEIFSKDTLFKPLHSTLSVN
                     SYHKSSLSLLKSHPKSPADTLPGRCEKMEPSLGTSAAQAMPPSQRQQEPGGNQEASFD
                     YYNVSDDDDSEEGANKNTEEEKNRDDVGTMQWLLEREKERDLQRKFEKNLTLLAPKET
                     DSSSNQRATHSARLDSMDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPA
                     HGGAGPTFNFRASTDPPTSEAEKLQKPSNCLQASVTSV"
     misc_feature    325..561
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     misc_feature    325..561
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     exon            305..457
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..2723
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..9174
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtcagca gttgtctctc ctcagttgag cctctttgga aacctctctt agacacacct
       61 tgtctcctag gtgattccag acaatgaaga ctgaccttca tggacgaact gggtagattt
      121 gggtggcttt ataatgaagg atccagccaa attgaaagat aattgattaa ttgggggggg
      181 cattggtaga aggctccact cctgagacac aagttcagtc tacagtgact gaccatgagg
      241 aaagagttaa gtatgtattg gaaaggaaat tcacaaccaa gccatgtctt aaaaagcaca
      301 aaaggtgatg tgtcaccaat cagtatgtcc cccatcagtc aatctcagtt tattccactc
      361 ggggaaatcc tttgcttggc catctcggca atgaactctg cgagaaagcc tgtcacccag
      421 gaggcgctga tggaacacct gacgacgtgt ttcccaggtg ttccaacccc aagccaagaa
      481 attctacggc ataccctaaa cacactggta cgggagagga aaatctatcc gactccggat
      541 ggctatttca ttgtgacccc acagacttat ttcattactc cttccctcat aagaactaac
      601 agtaagtggt accacttgga cgagagggta cctgacaggt ctcagtgtac ctctccacaa
      661 ccaggaacca taacgccctc tgcctcaggc tgtgtcaggg aaaggacatt acccagaaag
      721 cactgcgact cttgccactg ctgccgagaa gacatgcaca gcatgcatgc ctccactctg
      781 cagaggaagc ccgccaagga ctgcaaagac ccttactgcc ctcctccgct gtgccaggtg
      841 ccacccactg ataaaagcaa aagtactata aatttctctt ataagacgga aactctctct
      901 aaacctaaag atggtgaaaa gcagtccaag aaattcggcc ttaagttatt ccggctgagt
      961 tttaaaaaag acaagaccaa acagctggcc aatttctctg cccagtttcc tcctgaggag
     1021 tggcctctgc gagacgagga cacgcccacg actatccccc gggaggtgga gatggagatc
     1081 atccgtcgta tcaacccgga cttgacggtg gaaaatgtca tgaggcacac tgcactgatg
     1141 aagaaacttg aagaagaaaa agctcaccgg agcaaagccg ggtcctccgc ccaccacagt
     1201 ggaaggagta aaaagagccg gactcaccga aagtcccacg ggaagtctcg gtcacacagc
     1261 aagactcgag tgtccaaagg agatccttcg gatggctcgc atctggatat ccctggtgag
     1321 agggagtatg aattttgcga ccctctaacc agggccccca gagagggctg cttcatcatt
     1381 gaacacaaag gagacaactt catcatgcac agcaacacga acgtgatcga gtcccatttc
     1441 cccatgacgc cagaatggga tgtgtctggc gaactggcca aaaggagaac ggagatgccc
     1501 tttcccgaac cttccagggg aagctcccac tccaaagtgc accgaagcca cagccatacc
     1561 caggaccgga ggtccaggaa tgagaggtcc aacaaggcca aggagagatc caggtcaatg
     1621 gataactcca aaggccccct gggcgcttct tctctcggga ctccggaaga cctggctgaa
     1681 ggctgcagcc aagatgacca aacagccagc caatcataca ttgacgacag tacgttaagg
     1741 cctgcgcaaa cgattggtca tcaaagggct catattcctt ctgccagcta taaagaggtg
     1801 tgcattccag aaatagttgg tggcagcaag gaaccttcta gtgcttgtag ccttttggag
     1861 ccaggcaaat cccctgagag tatgccgtct tatggggaac tcagcccttg cccggcaaaa
     1921 acagctgtgg atgactattt tcagtgcaac acttctagtg agactgtgct cacagcaccg
     1981 tctcctttag ggaagaataa ggaggaccac gacactttga ccttggtgga gggggtaaaa
     2041 aagctgtctc catctgagag gcagaccccc cactcttcca gggatcctgt tgggcacaag
     2101 gaggagtcac caaaagggcc aggtgggggc cctgcagctt ctggtggtgt ggcagagggg
     2161 ttggccaatg gccgtcttgt ccaacatcat agtgcagaac ccagcaactt ggacaaaagg
     2221 aaagaaatat tcagcaaaga cacactgttc aaacctctac acagcacctt gtctgtaaac
     2281 agctatcaca aatccagctt gtccctcctc aaatctcacc cgaagtcacc tgctgacaca
     2341 ctgccaggcc gatgtgagaa aatggaacct tcccttggga cgtctgcggc ccaagccatg
     2401 cctccgtccc agcgtcagca ggagcctgga gggaaccagg aggcctcctt tgactattac
     2461 aacgtctccg acgacgacga ctctgaggaa ggggccaaca aaaacacaga ggaggagaaa
     2521 aacagagatg atgtgggcac catgcagtgg ctcctcgaga gggagaagga aagagacttg
     2581 cagaggaagt ttgagaagaa cctcaccctc ctcgccccaa aggaaaccga tagcagcagc
     2641 aaccagagag ccacccactc agcccggctc gacagcatgg acagtagcag catcaccgtg
     2701 gacagcggat tcaactcccc acgcactcgg gaaagcctgg cttccaacac atcaagcatt
     2761 gttgaaagca accgccgtca gaatcctgct ttgagtccgg cccatggcgg agctggtcca
     2821 accttcaact tccgcgccag tacggatccc ccgaccagcg aagctgagaa attacagaaa
     2881 ccttccaact gcttgcaagc ttctgttact agtgtatgat tgtccttctg cctcagatct
     2941 tctgtctcat tcgatacagc aacgtttacg acgattggga ctgatgttta catctcttca
     3001 aaggcaaaca tctcaagcac aggttggggg ttacttgagc tgtgctgcta agtaggctag
     3061 ggcaaaaaaa aaaatcttca tttcagagta ttgcttttca catgtatggc tctgtagcta
     3121 ccaaatagca gtatgggaga tacgtacact tccgcttcac taattgtatc tgagcacaca
     3181 taggaaagtc taaacactgt aagtggaaca tgcatttttc gatgtcatac agttgccaat
     3241 tccattctga aaatgccaca gagatgtgtt gctccctgcc ggcctacggg gtacgggccg
     3301 tgggactcat ccttgataac cccgccccct caaacccccg ccccctcaaa aaaaagccaa
     3361 gccgccacaa aatgtaaatg taggggtgtg tccattgtga gaaaaaacag tgccaaactg
     3421 ggcagaaggg accccagccc tttatgtgtg agtcctttaa agtaccagtc atttttcact
     3481 gtgagttttc acgacactct tgcaggagcc catggaagtg ggtcagaggt cccaatggaa
     3541 gttgttgggg tatttgtttt tactgttttc cagctcacta aatgcttgtc ttgagttttt
     3601 tgttttttta accttcccta atcacaaaca ggaatatagg cctttgaggt ggacaaagga
     3661 aaggaaatgc ggtctcatgg gggcacagca ctgagtgctg gagaagggtg tgtggatgac
     3721 caggagggat gaatcagata ctggagaagg atgcttccct ccttgggaca cttaggatga
     3781 tcgagctgac tatattagat gcggtgatta atctgttggg aagtaaaatg ttctttatga
     3841 tacaaatgaa gaatgtggcc cgagggtgtt attctttcta atggaaggga cataaatcta
     3901 ttttatgtag ttttaaatag aatgcctaaa ttaggctgtg gagatgattt ttagtggttg
     3961 taggaaaaga gcaaatttag ggagagttaa acttcaggcc ttttattcct gggaagatat
     4021 ctatagagac aacatttaaa gtaatttttg attagaaata tacatgggcc catgtaatga
     4081 acagcagaat gtcctcattc tgctggcgtg gtatattctt aatttgtact cccctaaagt
     4141 gtatcagaat gacacttatg cattcatgaa ctatgccaga gtaatgttta cagatacttt
     4201 gtagtgattt caggaggcgc cttttgggtg gacatcatct ttgcaatgac ttctccaagc
     4261 tctgctttgg tttaagacgt catgctcagt atcccaaggc tttgcaggag ggggaccact
     4321 aaccattaca cttcagtcct accagaaagg ctctcttcaa aagtcccttg atcttatttt
     4381 ctgagacgcg tggcatacct ctgtaggttc tgaaaatctt atctgcacgt gggttaggtc
     4441 tgatctcaga aaatggtctg aaacaaaatt acattcagtt gagtgtcaaa tgatttttgg
     4501 agccatatgc tttaatgaat ttatagataa ataacttaaa aatcagtata aaatattttc
     4561 actcaagatt tcagcaatga gcataagttt gtgagctact tctttttctg tgtcaggctg
     4621 aatcactagc aaggtgtcta agggagcaca gtcatatgaa gcagttggaa acatgtacat
     4681 tcattttgtc tgctatttgg aagttgtact attgggtcaa actgggctcc ttaagcttgg
     4741 tataaatttc tttttcttgc ttattgtaat gaagcttaag cacagttctc agtatactgc
     4801 tacattgttg aaatgcttaa gggaattggc ttcgaatccc atactctact tcctcctggc
     4861 atgcctcagt tgttcagaag cacattgttt ctctgattac ttaagtaatg tccagaaaga
     4921 gcaaccatgt atctgattac tacatagtct gtttgcttaa ggagccgtac accataagat
     4981 tcctggatct ggtctaaatc aatttgcccc ccccaccccg cgccctaaaa aaacctgctc
     5041 tgaaactttt ggcatactca gttcataaat aacagaactg ttaaaacaat acactaatct
     5101 ctgattgacc tctgaacata gtagccattg aaagaattga gtgccgtgcg agcaggagag
     5161 gacataatta tgttttaagc gaagctttaa aatatgcatt tttgatagtt caccaaaaac
     5221 aggtttacag aagacatttt ccaaacaaaa tgtgtacact atttgcctaa tcactatgga
     5281 gtacaagatt taaaaaaata ataagtggat aagcaaaaga acttccctta gaccagcagc
     5341 cattagcact gaacgatggg ctttaaagat gatgtaacac atacacagac attccgtgga
     5401 gaaacactct cgtctgaatc taatctggat tcttgaatgg agaggcattg gtggtaggag
     5461 gcacatggca gtgtgatgcg tacatgtgtc taagatggtc tcctcaaaat ggtgagactc
     5521 tttgactctc acagcctcga gactctctcc aggcttcgtc agttttctcc actggaacca
     5581 tagctctgtg ttctgtgacg gcatgtctag ttttagagtt tatcaacgga aaggtttaca
     5641 aaactgaatc tggttgaatc tctgtgaggc attcaacttt aaagggtcaa cacatctgtc
     5701 ggcattttgc acacgtatgt attattatga tacagcatat tactttatgg taatttttat
     5761 tttttacata taactacctc catgaatttg atgaaatggc agcagtgtgt ttaagtgtgt
     5821 tcttcagaaa aagcaatgtt gcaaacgtgt ttcagcggta ggccatggcg tggcgtgtgt
     5881 gtcggtgact tacccattgg actcatgacc ttttcattgc cgtgattttc tttcacaaca
     5941 ttctttggct cccaactgta agcctgttgt cctctttttc tctctccctt ctcccccatg
     6001 aaagcacatt tgatttgtta caaatgaacg aacattttaa aattactgtc ttccctgctt
     6061 ctacacgctc actattagag aaaaaaaaaa gtcttctctg gcaaagagcc acttggtaaa
     6121 catttaggaa gttattaatt cctatagaaa ttacattgaa ttgttagggt gtttttttcc
     6181 ccagtaacaa aagatatgtg aaaattttgg actgccaact tgaagcactt tgggcctctc
     6241 tgcctctatg ctaccctatg gagcccaaac ttttttttat taaaagaact gtgccatgca
     6301 ttctgagatg tctgttaagt aatttgtcta ccctttgatt gcacatctca ggagacttta
     6361 atgagtgcaa gaatagggtg tgtgtgcacc caatagagaa aaccaatgtg agagctgaaa
     6421 tgggagtagc cgggtagaaa taagaaatgc cggtgtcttt gatgttggag aattcaagtt
     6481 caggaaatat gaatggaaag agaatgtgga ggagcagtga tttgaacacc agctgttcct
     6541 aaatgtctct tttctgagaa ctcagccaat attgttacaa tgtcaccaag acaggaaagg
     6601 cagtaaggac agaagaacat agtttctctt ttaggttagc atagctttgt aaagtcctac
     6661 ctaggattat ccactggtca ccacaaagtg tacttgaaga taaagtttgt aacttcagtg
     6721 ataggcacag ttctcacaaa accatttggg aggggtagcg ttctgagctt gcactaacaa
     6781 ccaacgactg gtaatgttct gcagctcatc tggcgatctc aaagtgcttc cgaggcatta
     6841 ggcgtacaat tgcagggcag gtccagtttc tcatacccag gcttgacagg agcaaacaaa
     6901 tggagtgtct tgagatcacc cataaacaca atggcagctc tcagtgacct attttctatc
     6961 tgtttgatag gccatggtga gaaatcacta agatgctatt tttatgatgt gtgctaataa
     7021 agaaaacaaa tacagcttga caccttgtcc atttcattca aagaggtatg ggtgtttgga
     7081 atctcagcac ctcagcaccc cttactggta ttgagttatg acgtgggaga ggagcaaatc
     7141 cacaccaatg ccactgtcat ccaaagccag tccaggcatc cacctttgtt tacagctcct
     7201 tattaggtcc ctgtcatatc tgtgttaaaa caaaacccca tctccaggaa cattggctgc
     7261 tccaggcagt ggaaggtgct gaaacagttg tgtttttttt ctcttaattt tcctttaaaa
     7321 tattcatcaa gcactcctca cagtgttcag caacatacca ctcactacgt tatatcaagc
     7381 cctgcttcgt agaatctggg aagctgatcc agttccaaga gttttgtcaa attatgagat
     7441 agaaggtctt tgacttctgc tttctccttt cccacagacc agacccacac ccaactagca
     7501 gtgcagtgca gaccacagta gactcgaagt ggtgcttcct cccccgaccc ccgaccccca
     7561 tccattgtca aagccatcca ataatgtcct gtgagcgagg gactctttgg cccgtgttta
     7621 aggcttgggg aaattagaaa caagaaaaat gaatgcaaaa agccatggga ggcattggtt
     7681 tcctttgggc tagttaaaca tggtggcaag ggattgctat tgtatgagct ttgccaagaa
     7741 atacaaaaga ctcagccatc accccatcct tctcgaagaa ggttttatag tattaatgat
     7801 acaagtgata ttttcccatg gagttttcct taggatacat ttcataaatt atacacatga
     7861 gacattttag cattagatct catgtgtttg ccaaaggtac tggcttctcc ctggcttgga
     7921 gtccatcctc ttgtcttgca tcagcaacgc agaggggctc ctcggtgatg gcttctagaa
     7981 tacatatgcc tgtgtcttta ttgttgtgca caggcttaac atttgcaaaa ttgagaattc
     8041 ggcaaagctc caggggaact aagcggtctt gtgattgtat gcaggcagtc agaggccttt
     8101 aatggctcat tgtcggcttc acttgtgaac acatacaccc tcccgactag gaaaagggtg
     8161 tttccaggtg aggtaccaat ggcttggaaa ggcagaaatg gaaggttaga gcttggctgg
     8221 tccttgtgca cctgcctacc tccctgtcca aaggctgacc ttggtacccg cccccccccc
     8281 attccccttc tctcacccca aaagaggtac caaatctgag acccgagctc tccttcaatc
     8341 ccagtcctct acagctccag gaccttcata tagaacattc tcgacagccc cgccttcctt
     8401 tcctctgagc gttaccctct ccgcctcccc accaccacca gatacctacc ccaccaccac
     8461 tctttccaca ttggaagaac agaatactgt gtagtattgt gcacgcatgc cagttaggag
     8521 tagaactgcc ctagggtcac cttcacatca gtgtcaacag ctacaaacat aaagtcctta
     8581 gagcagtcac atccatactc tctggaagag aattcaattt gaccatctaa gttccaaggg
     8641 atcgtggctc tgcgggcgtc tttctctgtg tggctgactg tgactattac attagggtca
     8701 gtgagctaag aagtacgtgt gggattcact gtgttaggaa ggagttttgc agccaagact
     8761 gccttgaata aaaatgtttt tgcactgaaa aaaaaaaact ttaaatgact tggtctctgg
     8821 ttgctgtaaa ggtcatccaa gatggatgtt ctgtttatat tgtatagtat ttcataagaa
     8881 ataactgcag ttcatgaaac gtcttcccta atgttactga tttctaacag cacatttgta
     8941 acatggtttt tatcgtgtcc gtgtaccata ctgtaaatga tgattccttg tcatgcttag
     9001 tataataagt taaaaggaaa aaaaaaaagg acagggattt ttgtaagtct atatttgaaa
     9061 gtccctccat atggtaatat tgtgttcatg ttgtttatgt agtgttgtgt gaaatatcca
     9121 ttttggattg tgttactttt taagatatta aataacattt ggttatatgt gtaa
//
LOCUS       NM_001436795            1343 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus regulatory factor X-associated ankyrin-containing
            protein (Rfxank), transcript variant 2, mRNA.
ACCESSION   NM_001436795 XM_063275377
VERSION     NM_001436795.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Wiszniewski,W., Fondaneche,M.C., Louise-Plence,P.,
            Prochnicka-Chalufour,A., Selz,F., Picard,C., Le Deist,F.,
            Eliaou,J.F., Fischer,A. and Lisowska-Grospierre,B.
  TITLE     Novel mutations in the RFXANK gene: RFX complex containing
            in-vitro-generated RFXANK mutant binds the promoter without
            transactivating MHC II
  JOURNAL   Immunogenetics 54 (11), 747-755 (2003)
   PUBMED   12618906
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Lin,J.H., Makris,A., McMahon,C., Bear,S.E., Patriotis,C.,
            Prasad,V.R., Brent,R., Golemis,E.A. and Tsichlis,P.N.
  TITLE     The ankyrin repeat-containing adaptor protein Tvl-1 is a novel
            substrate and regulator of Raf-1
  JOURNAL   J Biol Chem 274 (21), 14706-14715 (1999)
   PUBMED   10329666
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Masternak,K., Barras,E., Zufferey,M., Conrad,B., Corthals,G.,
            Aebersold,R., Sanchez,J.C., Hochstrasser,D.F., Mach,B. and Reith,W.
  TITLE     A gene encoding a novel RFX-associated transactivator is mutated in
            the majority of MHC class II deficiency patients
  JOURNAL   Nat Genet 20 (3), 273-277 (1998)
   PUBMED   9806546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275377.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1261487.1,
                                           SRR26360186.526449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000016.1  19314735-19314933
            200-423             JAXUCZ010000016.1  19315486-19315709
            424-618             JAXUCZ010000016.1  19316487-19316681
            619-699             JAXUCZ010000016.1  19319936-19320016
            700-765             JAXUCZ010000016.1  19320608-19320673
            766-866             JAXUCZ010000016.1  19320847-19320947
            867-992             JAXUCZ010000016.1  19321077-19321202
            993-1059            JAXUCZ010000016.1  19321578-19321644
            1060-1140           JAXUCZ010000016.1  19321972-19322052
            1141-1343           JAXUCZ010000016.1  19322625-19322827
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1343
                     /gene="Rfxank"
                     /note="regulatory factor X-associated ankyrin-containing
                     protein"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
     exon            1..199
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            200..423
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    354..356
                     /gene="Rfxank"
                     /note="upstream in-frame stop codon"
     exon            424..618
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1211
                     /gene="Rfxank"
                     /note="isoform 1 is encoded by transcript variant 2;
                     DNA-binding protein RFXANK"
                     /codon_start=1
                     /product="DNA-binding protein RFXANK isoform 1"
                     /protein_id="NP_001423724.1"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
                     /translation="MEPTQVAENLIPNQQSLAPDLEDPEDRRDESPDSSDTVVLSLFP
                     CTPDAVNPEADASASSLQGSFLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGEL
                     SQLKDHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAKERESAL
                     SLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE
                     ADSGYTPMDLAVALGYRKVQQVMESHILKLFQGTLGPADPE"
     misc_feature    <708..1175
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <708..1175
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    708..791
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    708..791
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(795..797,801..803,813..818,825..833,837..842,
                     852..854,861..863,888..890,894..896,900..902,912..917,
                     924..932,936..941,951..953,960..962,987..989,993..995,
                     999..1001,1011..1016,1023..1031,1035..1040,1050..1052,
                     1059..1061)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(795..797,801..803,813..818,825..833,837..842,
                     852..854,861..863,888..890,894..896,900..902,912..917,
                     924..932,936..941,951..953,960..962,987..989,993..995,
                     999..1001,1011..1016,1023..1031,1035..1040,1050..1052,
                     1059..1061)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    795..890
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    795..890
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    894..989
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    894..989
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    993..1079
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    993..1079
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            619..699
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            700..765
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            766..866
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            867..992
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1140
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1343
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttccgcc gaacccgggc ggttggggtt ctaaagcggt tctctctgcc atgaaccttc
       61 ccgcgttgcc ctctctaggc ccctctagcc cttccggggt cccgcaacac ctttctttcc
      121 tttcagttgc atctcaggtt cttccatagc gaaggtagcc agtagagcca aaaaaacgga
      181 accggaagtc ggaaggctgg acaggggtgc gcaggcgcag tggaggagtt ctcctgtagg
      241 aatagtcctg gcgtattaag ttgctgctct atgtcccagc agaagaagct agaggactgg
      301 gcgtccggtc accaacttgc tcctcacgag atctactgga ctagaaaagt ttgtgaacag
      361 agcttcccga gttttgggag agccaggctg gcagcgtaag ggaacggagg aggctggagg
      421 gagcttcctc gatggagccc actcaggttg cagagaacct catcccaaac cagcagtccc
      481 ttgctcctga cctagaggat cctgaggacc gcagagatga atccccagat agctctgaca
      541 ctgtcgtcct cagtctgttc ccctgcaccc cagacgctgt gaatcctgag gcagatgcca
      601 gtgcatcctc actacaggga agtttcttga agcactccac aaccctcaca aaccggcaac
      661 gtgggaatga ggtctcagct ctgccagcca ccctggactc cctgtctatc caccagcttg
      721 cagcccaggg ggagctgagt caactgaagg atcacctgcg aaagggtgac aacctggtca
      781 acaagccgga tgaacgtggc ttcacccccc tcatctgggc ctcagccttt ggagaaattg
      841 agacagtacg cttcctgcta gactggggtg ctgaccccca catcctggcc aaggagcggg
      901 aaagcgctct gtcgcttgcc agtatgggtg gttacacgga catcgtgagg ttgctgcttg
      961 accgtgatgt ggacatcaac atctatgact ggaatggggg gacaccactg ctctacgctg
     1021 tgcgtgggaa ccatgtgaag tgtgtggagg ccttactcgc ccgaggtgct gacctcacca
     1081 cagaggccga ctctggctac accccaatgg acctcgccgt ggccctagga taccgcaaag
     1141 tgcaacaggt gatggagagc cacatcctca aactgttcca gggtaccctg gggcctgcgg
     1201 acccggagtg aagacagcct gttgggaacc caggcactca gggacaaacc agtcagccca
     1261 caactggctt ggaaggcagc tcctggacag tggtgggaag agccctcccc aacaggaacc
     1321 aataaatctg tgcagaactt gaa
//
LOCUS       NM_001436797            4721 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 2, mRNA.
ACCESSION   NM_001436797
VERSION     NM_001436797.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4721)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4721)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4721)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28084.1,
                                           SRR26643289.15646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  123105380-123105468
            90-190              JAXUCZ010000005.1  123106498-123106598
            191-267             JAXUCZ010000005.1  123109158-123109234
            268-292             JAXUCZ010000005.1  123118303-123118327
            293-438             JAXUCZ010000005.1  123122432-123122577
            439-600             JAXUCZ010000005.1  123130554-123130715
            601-733             JAXUCZ010000005.1  123131303-123131435
            734-798             JAXUCZ010000005.1  123132010-123132074
            799-871             JAXUCZ010000005.1  123134055-123134127
            872-1023            JAXUCZ010000005.1  123138897-123139048
            1024-1105           JAXUCZ010000005.1  123139751-123139832
            1106-1200           JAXUCZ010000005.1  123141269-123141363
            1201-1328           JAXUCZ010000005.1  123146672-123146799
            1329-1468           JAXUCZ010000005.1  123150654-123150793
            1469-4721           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4721
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..89
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            90..190
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="upstream in-frame stop codon"
     exon            191..267
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1797
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform b is encoded by transcript variant 2;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform b"
                     /protein_id="NP_001423726.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MFMFNWFTDCLWILFLSNYKPSVESSSPGGSAASEDHEFDPSAD
                     MLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEE
                     EEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQD
                     AQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKE
                     NEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYE
                     LVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRT
                     RSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRA
                     PSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGN
                     KKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGS
                     SEFFQEAVSHGKFEEHENTND"
     misc_feature    802..951
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    802..951
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1120..1254
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1120..1254
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1120..1122,1210..1215,1219..1224,1228..1236,
                     1240..1248)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1120..1122,1210..1215,1219..1224,1228..1236,
                     1240..1248)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1282..>1722
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1282..>1722
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            268..292
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            293..438
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            439..600
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            601..733
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            734..798
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            799..871
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1023
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1105
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1200
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1328
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1468
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..4721
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgag tctcccggct gcaggcggat ggatggggcg tctccaggcg gcggcggcag
       61 cagcggaggc ggcggtagcg gcggcggcta tggtgtggtg gctcgattct cccagtgcct
      121 ggctgagttt cggacgtggt taagaaccaa ctggttgagg ttcaatgcag acaagacgga
      181 tgtgatgctg tagaaaatgt gcatcagatg tttatgttta attggtttac agactgtctc
      241 tggattcttt tcctgtcaaa ttacaagcca tctgttgagt cttcaagtcc agggggctca
      301 gcagcgtcag aggaccatga gtttgatccg tcagctgaca tgctggttca tgattttgat
      361 gatgagcgaa cattagaaga agaagaaatg atggaaggag agacaaactt cagttctgaa
      421 atagaggatc ttgcgaggga aggcgacatg ccaatcgacg agcttctcag cctctatggt
      481 tatggcagca ctgttcagtt acctgaagag gaggaggagg aggaagaaga ggaggaagaa
      541 ggtgaagatg atgaagatgc ggacaatgat gacaacagtg gctgcagtgg ggaaaataaa
      601 gaagagaata taaaggattc atcgggtcag gaggatgaaa ctcagtcttc caatgatgat
      661 ccctcacagt ctgttacttc ccaagatgct caggaaataa tccgcccacg tcgatgtaaa
      721 tattttgata caaatagtga aatagaagaa gaatctgaag aagatgaaga ttatattccc
      781 tcagaagact ggaaaaagga aatcatggta ggctccatgt ttcaagctga gattccagtt
      841 ggcgtttgta gatacaaaga aaatgaaaaa gtgtatgaaa atgatgatca gcttctgtgg
      901 gatccagaat atttaccaga agataaagtg attgtctttc ttaaggatgc atctagaaga
      961 acaggggatg agaaaggtgt agaagcaatt cctgaaggat ctcatataaa agacaatgaa
     1021 caggctttat atgaattggt taaatgcagt tttgatacag aagaagcctt gagaagactg
     1081 agatttaatg tcaaagcagc tcgagaggaa ttatctgtgt ggacagagga agaatgtaga
     1141 aattttgaac aagggctgaa ggcctatggg aaagattttc atctgattca ggctaataaa
     1201 gtccgaacaa gatcagttgg tgaatgtgta gcattctatt acatgtggaa aaagtctgag
     1261 cgttatgatt tctttgctca gcaaacaagg tttggaaaaa agaaatataa tcttcatcct
     1321 ggtgtaacgg attacatgga tcgtcttttg gatgaaagtg aaagtgctgc ttctagccga
     1381 gcaccatccc ctcctcccac cgcctcaaac agtagtacca gccagtcgga gaaagaagac
     1441 ggcacgctca gcaatagcaa tcagaatggt gtgtcatcta atggaccagg agaaatacta
     1501 aacaaagaag aagtaaaagt tgaaggctta catgttaatg gaccaacagg tggaaataag
     1561 aaaccacttc ttacagatgt ggacactaat ggttacgaag aaaataacct tgccactgac
     1621 ccaaaacttg cccatatgac tgcaagaaat gaaaatgatt ttgatgaaaa aaatgagaga
     1681 cctgccaaaa ggcggcggat aaacagcagt gggaaagaaa gtccgggttc gtctgagttt
     1741 ttccaggaag cagtctcaca tgggaagttt gaggaacatg aaaacacaaa tgactaactc
     1801 ttaggcctat tttactttct ttgcagtaaa gtctggtttg actacaattt tcagggttgg
     1861 gggggtgacc tttagaaagc tgatttcctt gaagcagttg ttaactcttg aaattggaat
     1921 taggtcctaa ctttaagaaa tgggattcat aattctactt tttgcaagtt cttttacttc
     1981 aaattttgaa gccctcttta aggatataaa aacattggta aatttgaatg acccaaagac
     2041 ttaactgcac cttctccttt gagaaacaag tcatatttga ctaaaaggta atctttcctt
     2101 attctttatg aggaagaaaa aagtttgttt ctgttcaaca ccaatttttt ttattatcta
     2161 gaaatgtctt tacaacagac atttttctct ccatacaaat tgaacatcgt cattaaggaa
     2221 accctcatga atcctgaagg ttatgctagc atgattttta tatgtagaag tttaaaaata
     2281 aaccaagtca ggtttgtatt tgtaaaattg ttgacatcaa tgatgtcttt ccatattctt
     2341 atctgggctt aagaaataca ttctgtattt ttccagattc tttgtagcct ttgaaagatt
     2401 tttacagtac atatgtcttg actgagctgt cctttcttaa tacaaaaaaa gcttgtataa
     2461 ttttcttaac ttgtacagtt ggtaaacttt tatgagagga actgatattc tgagtctgtc
     2521 agctttcatt ttattttgct aagatttttc taatgaattt ttaagtgtgt gtgtagttaa
     2581 ccaagtcatg tttcttatcc aggtggtaaa agcattcata aagaattatg ttattttcaa
     2641 acttctactt actgacataa tttgggactt ctaaatttca gcatgatact cagattacaa
     2701 gcttgtttgc atttgctata attttataaa ttaattgtga aacaaaacaa agacttactg
     2761 tcagcttaag tgtgtagatg tatcgtgctg aatagaatcc tgttcagtta ctctcatgtg
     2821 ccctacaaga tttctcattg tttcagtcaa cagaaaggga aggtcacgtg atgttgcaat
     2881 attgccacat ccaaggagta actgttgaca ggtagcaata ttcattttta tgagaaaata
     2941 gtggttttaa gaattttcag atctttccag ttgtaatcca gtttgtcaca tttgatactt
     3001 tttccaaaat gaaacacata caaaataacc attgttctgt gtgactttaa aaagggttat
     3061 tgcactagcc ttgtaagaat ggatgccatt ttattgttag tgcaaaattc ttcttacaaa
     3121 atgtagtttt atacagctga tagaccaatc tatctctgga ctgtttttta gtgaatgatg
     3181 attaactacc ttttctcaca caggcacatc cccaaatgct gccttcagtt tgatctcagc
     3241 cgtcagttca agagccactg ctttcaaaga cagatctgtg tccttttagt ggctcagttg
     3301 tctgatgcag ggtgggttaa ggtttgcact gagaatgatc gcccaggcct ctccctcata
     3361 gtattcttac atttgtccag actgcttccc ttcacaatgg gtacaaactt ttctttcccc
     3421 aaatcagtat tagaagccac cttgacagca catcataata atacgcattt actgttttct
     3481 gcagaaatag tccagtgagt tgccttcagg tggaagtgct gagaagcacg agagggttta
     3541 gtttgtttta ttgaaaacat taatttatcc agaatggcag taggtcaagt acctttagca
     3601 gatggtcata gcttgtctcc ctgcccaccc ccacagagtc tcactgtgta gcccaggctg
     3661 gcctggaact taacaaccct tctacctcag cccgctaatg ctgagattgg aggtgtttcc
     3721 caccacaccc agcaacagtc tattttctaa agcaggtttt attatatgag tccaggccat
     3781 cccagctcct tgtcacaggt gatctttaag tgatgctatg ctttttaatc attacactat
     3841 ggaagatgtc agtccgcctt ttaaaggatg cctctgctcg acacgttctt ggacttctcg
     3901 aaactgttgt aacaggaacg ttttaaggaa attctcaggc atgttggcaa atgtgccagg
     3961 tgtataagtg ttcataaatc ttttcttttt aaagtatgca taatgaaaca ttcctctaat
     4021 acacaaggct cagcttttcc caactatatt ctgtgtttgt ataggtattt caccctttgt
     4081 tcaaaaaatg cagccactga aacttaagtc attgcacttt taaacagttt gacaatatca
     4141 tgagtaatct gcttaagatt tggtgtattt cctaactgtt gaacacttaa gtaactgaga
     4201 tgagaaaata agcattcatg agtagggatg tagctcagtt gctggaatgc ttacccaaca
     4261 tgcatgcaaa atgggttcca tccccagtac cacaggaact gggtatagtg gtgcatgcct
     4321 gtcatcctaa gcacttggga ggtggaggca ggagaatcag aagttcaagg ccatcctcat
     4381 tacctggtga gttgaggcca gcctgatatg ctgactcaga tagaaatggc tctgttggta
     4441 gttattaggt cctagccaag cactgtcatt ttcatctgga acatacaatg atgatgtatt
     4501 tatgatgtat tctcactaag gttcacaatc tgtaactcag ttcaacacag atctcttgag
     4561 ctttaaaagg tatttgaagt aatttaagta ggcattcaaa attatgaatt agatgttttt
     4621 aaatttctgc ataataattt tgcactgtaa aatatgtcct ttctcccatt tccttctgcc
     4681 attctgatat gctcattaaa atatttttgt aagcatactc a
//
LOCUS       NM_001436806            4644 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 2, mRNA.
ACCESSION   NM_001436806
VERSION     NM_001436806.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4644)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4644)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.271386.1,
                                           SRR26643293.74850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000016.1  52867643-52867789   c
            148-1244            JAXUCZ010000016.1  52848306-52849402   c
            1245-1513           JAXUCZ010000016.1  52836572-52836840   c
            1514-1664           JAXUCZ010000016.1  52822585-52822735   c
            1665-4644           JAXUCZ010000016.1  52818692-52821671   c
FEATURES             Location/Qualifiers
     source          1..4644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..4644
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..147
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            148..1244
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1792
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 1"
                     /protein_id="NP_001423735.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQNDDDFKEG
                     INKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKPKFPSKE
                     QHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYYTDGEES
                     SDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIGSDMQNK
                     PDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPASTPDSSP
                     AQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQNFAPKSS
                     VLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNYSFTREE
                     VRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQRIERENM
                     ALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRGASRTSS
                     ATSGLSCKTDRSVLDTSSGFLLRPKPPNVRTAWL"
     misc_feature    185..187
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    218..220
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    416..1054
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    626..628
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    641..643
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    644..646
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    866..868
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    938..940
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    1226..1534
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1226..1534
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1382..1456
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1245..1513
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1664
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..4644
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccggta ctcacccgca gcggacagcg gacggccgcc gccagccggc tccaggaaga
       61 ggcgaagtcc ggcggctggg cgcgcgggct ccagcagacg agcgcgacca gtgtccccag
      121 cagcaaggcg gccgcggcgc agctcagata tacttttggc atcatggatc ggtttggcga
      181 tatctcagaa ggtgaagtgg accattcttt ctttgacagt gattttgaag acacaaagaa
      241 atgtgaaagt aattccattt ttgacaagca aaatgatgat gactttaagg aaggaataaa
      301 taaggacatc aaaaatttaa acttgaaatt tggagtacaa aatgataacc ttaaagagaa
      361 aatagataat gacacagaaa atgtgaacgt gaaacttggg atacaaacaa aggaaaatta
      421 ccttactcag aagggaaatg aaaggaaacc aaaatttccc tcaaaggaac aacatgtaga
      481 aaatgaccct atacaaacaa gaagtccctc attgttgact tcttcaaggt caaaaaaact
      541 gtgtgatacc acaaaaggaa ataaactaca tttgcctgtt ccaaatagaa ttcctaaaat
      601 tgtgaaaggt gaggatgact actacacaga tggagaggaa agcagtgacg atgggaagaa
      661 gtaccacgtg aggtctaagt cagcgaagcc ctctagtaac ttaaaaaaga acaacacaag
      721 taagaagtat tccaaagcca gttcctcctc tctgtcttcc tcatcttcac gatcaagctc
      781 agactgctca gatataggat ctgacatgca aaataaacct gattcaggtt catcagggaa
      841 acgagtttct agtgtaaccc cctcatcacc aaagcagaag tgtaagtcag gaagaaaatc
      901 aagtgctaaa cagaaggcag gtgactataa tgcagagtca gaagacaacg taacagacgt
      961 aactcccgcg tcaactccag acagcagccc tgcccagcca tttgagttga gccaatcaca
     1021 gaatcaaaaa gtaaaagtta aaagacaaga aaatgtgagc cgggatgtgt atgaggatgt
     1081 ggaggcttta aagaatgatt caagatgtct gaaatcagcc aaaaggaaag aaaagcatgg
     1141 acagaatttt gctccaaaat catcagtgtt agatgcaaat ctagaccgta gatccaagca
     1201 aaaagtctta catgacacaa tggaccttaa tcatctgttg aaagctttcc tgcagttaga
     1261 taaaaaggga ccacagaaac atcactttga gcagccttca ataataccta ggaaaaacta
     1321 ctctttcaca agagaagagg tgagacagat tgatcgggag aatcagaggc ttttgaaaga
     1381 actgtcaaga caggctgaaa aaccaggaaa caaaagtaca attcctggaa gatcgctcgg
     1441 ccatccacct aagttgtatc acagtgctct caacagacag agggaacagc aaaggattga
     1501 aagagaaaat atggctttat tgaaacggct tgaagctgtg aagccaacag ttggcatgaa
     1561 acgctctgaa cagctgatgg actaccatcg gaatatcagt tacctcaacc cttcaccgtc
     1621 cgtcagacga gtgagatcta ctcttggcca ttacagccca ctgagaggag cttccaggac
     1681 atccagtgca accagtggtc tcagttgtaa gactgatcga tcagtgttgg acacatccag
     1741 tggctttttg ctaagaccga aacccccgaa tgttcgtact gcttggttgt aaaacctttt
     1801 tttatgatat acattgttca tctgttggtc ctgttttaac gatgtatttt tctgtactac
     1861 tataactatt tgcaaacatc tgtcatactt ttccaacaat ttatacagca atgagtataa
     1921 tttattgtta ttcagtgcaa attgttatca aaagacactt tgatgtaaaa tcagtgtttc
     1981 atgcagtggc atatttatag gagccatatg tctatttcat agagaaaggt gtatgcatga
     2041 atgtttcttc gatataggaa ttcagctgtt gtgctgacaa agcagcagtg gtggtaatcc
     2101 atgttgaaac caagacgctc actatatagt tcttaatcta tatgagtttc agttattgta
     2161 agcgttaagg tgctttacct tgtaaactta agcgcctcat gcttctgtct gctttagact
     2221 gtctgtaaca cgagtcagca cttgcttatg tgagtgttcc actccaaatg aaaaaaactt
     2281 gaaatttgtt ttcatggaga agctggtgta gtcttgatga ggagcatgag cagcttgtat
     2341 cagtgcagct cttgcttgac taacgacgct tctccctaag tctgattatc tattccaaac
     2401 cgtttcaccc catgaatgag gggttcactt tagaagcgtc tgtttcatgt ttatatgcag
     2461 tctggtaaaa tacccttaag gattctgagg caagagagag gctttaacag cttcgagtct
     2521 tgtgacttgt gactggtttg gatccagatc atttgcatca ttaacaaaag catgtgttta
     2581 tggatcaggg agcaacattc ccagcttgaa gaccagggtg tgttagagca gtgtttgaaa
     2641 tgatactgtt agtgtgtgtg ctgtcgttgt gtatttattg tattaataga atgcttagag
     2701 taaggaagaa atgattagag aaaccaaata caaacaagaa agaaactaat cacacattgg
     2761 tcacagctac tgccttaatg ttagtgaatg tccttggctt gctttagctg agtcctggaa
     2821 gcaccagtct tcagtctcat gtttgaaggt ctgttaatcc tcatggactt gctagtgacc
     2881 cacagatgtg aaatagttga ctatgaaaaa ctagaatatt ttcctgtcaa cctagaggct
     2941 gttcttttgt agaacaaagt gtgtgatatt tcatagtcat agcctttcat tgctggtctt
     3001 gtcagtatgc ctttagtaaa taccttttat attcaatgac acgcttttct taaaatatga
     3061 attttccctg accacagaga gatctgtctg gttcagtgct cagcactgga gcatgtgggc
     3121 cacacctgct tcgccttccg tagcagggag gccgactgcc cttaccaagc accaggtcac
     3181 acattgttag tctcacttta atggatggtg ttccagatag agcagtgatg gtaggaaatg
     3241 gtgagaccac aacaatgctg atatacatag catacacaca catacactct ctctctctct
     3301 ctctctctct ctctctctct ctctctctct ctctctctct cacacacaca cacacacaca
     3361 cacacacaca cacacacaca cacacacaca cgactaaggg tttttctgct gcttttggag
     3421 gactgtaaca ttctataaca atttatttct ttgttttagt gaacaagatt ttgtacctgc
     3481 tctatatacc ccttttaatg tttttgtaac aacttaaatt taaaatgcaa cattttggca
     3541 tttgctcagt agtgaatcac tttaaagcag atttttgtgg gaaaaaaact tgtatatgta
     3601 aaaccttcta tgttcacagt ggcattagcc taggcacatt tttgttggtc tctccaagtt
     3661 ccatagataa actagaattt gattttaaat gctaatttat gtcttagttt ttactgtttg
     3721 gaagaagttt aactaagtgt tactgatgac aaggattcaa cctcaagtaa agggcaacca
     3781 tcttttaaaa gcaatttagc ttgttatatt gtaggtgcat agatctggtg actgtagaga
     3841 tgggtaggag ttatactcag aactcactga tggacgtcaa ggtactgtta ggtaggatta
     3901 ggaagccttt gcaatggagg agtcatgagt acattaatct cttcagcctc accaacacaa
     3961 acatgtactc ttagcactgt tgcatggttg gctggctggt ccttaccaag catacttgga
     4021 aggcccacat ctgtagctag aaagcgtgct ggtctgctgc ctagagacag atctgagaac
     4081 tgttttcatc tctgtcaaat gttatctcct tttctagtaa gtttttgtga gatttcaaat
     4141 tattaaaatt acttcttaag gagtagctac tacctcatcc tccccaactg actctttcag
     4201 tccccatcaa aacctgctct aactgctatt ccagttaaca ctctatggct tgcttgttta
     4261 ataacatcat gcacttgtgc tcaacccaag tatcagaaac gcgactcgcg gctttgagag
     4321 gtgattgtga taggtctgct tctcatctgc agatacaatg cagcaactcc aaagtattaa
     4381 gatcacacta agctgaagat gcacctttgc cctggttagc aacgcaaaac cgtatcgtca
     4441 tacatgccaa ggccttagcg tgtagatgtc tgtacaccgg cacagcgaat gagctcactg
     4501 ctaatggctg agttgcttat tttcatgaac aaagattagc aagaaactgt taaaccatct
     4561 ttttaaaaac tgttctagtt tgtcatattt taggcatgaa gaactagctt ggcttactga
     4621 agaaataaaa gatttaaaga gaac
//
LOCUS       NM_001436772            1857 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 5, mRNA.
ACCESSION   NM_001436772 XM_008763779
VERSION     NM_001436772.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_008763779.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093606.1, SRR26643293.28361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1253           JAXUCZ010000005.1  102900532-102900650 c
            1254-1857           JAXUCZ010000005.1  102898944-102899547 c
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1857
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1278
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 5 is encoded by transcript variant 5; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 5"
                     /protein_id="NP_001423701.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEHQTTCNLQ"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    <535..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="DNA topoisomerase 2-like protein; Provisional;
                     Region: PTZ00108"
                     /db_xref="CDD:240271"
     misc_feature    <535..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="DNA topoisomerase 2-like protein; Provisional;
                     Region: PTZ00108"
                     /db_xref="CDD:240271"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1253
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1857
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagaagaga
     1141 aagggtggaa gaaacttcca ggctgctcac aggaggaaca tgctaaaagg ccaacatgag
     1201 aaagaagctg cagatcggaa acgcaagcag gaggaacaaa tggagactga gcaccaaaca
     1261 acatgtaatc tacagtaata aaaatatatc tcattttggg ctcaaagcat taatccagta
     1321 actgaaaaga gaatacgagt ggagcataca agcgatgaag atcttgagac agactcattg
     1381 gactgaattt tcccctcccc ccttgatgga agaaatgttc cagattctaa attgaggact
     1441 tcactattaa tggcattatt aactgtgtta tgattgttaa caaaatatcc tgtaaggtac
     1501 acactacata ttaaggttgg ccatcattcc tgtttttttt tttagccaag cttaaaatga
     1561 agctttgtgt ttgaagttat aacaaacata gatgaagtcg gtggttgtac attatttcat
     1621 ttagaaaata tgaaaactca ttttgttttg aagataggta ttaaactgaa atagctatta
     1681 cgttcttgaa aaatggggca ggtgtgccct tcccttgaca ttcttttgtt gttaagttct
     1741 ttagagtctt gttttttttt ttctttttaa tcctgagaga ttaaacagta gacttgttaa
     1801 gtaaaaatat gaaactgtaa ccaaaatttt aaaataaagt tttttttaaa aaaaaaa
//
LOCUS       NM_001107965            2143 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus beta-1,4-galactosyltransferase 2 (B4galt2),
            transcript variant 2, mRNA.
ACCESSION   NM_001107965 XM_001072098 XM_242992
VERSION     NM_001107965.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Yoshihara,T., Sugihara,K., Kizuka,Y., Oka,S. and Asano,M.
  TITLE     Learning/memory impairment and reduced expression of the HNK-1
            carbohydrate in beta4-galactosyltransferase-II-deficient mice
  JOURNAL   J Biol Chem 284 (18), 12550-12561 (2009)
   PUBMED   19265195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107965.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360172.16374.1, SRR26360194.270561.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000005.1  136706315-136706452 c
            139-494             JAXUCZ010000005.1  136705851-136706206 c
            495-730             JAXUCZ010000005.1  136705403-136705638 c
            731-921             JAXUCZ010000005.1  136702152-136702342 c
            922-1044            JAXUCZ010000005.1  136701810-136701932 c
            1045-1149           JAXUCZ010000005.1  136701595-136701699 c
            1150-2143           JAXUCZ010000005.1  136697857-136698850 c
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2143
                     /gene="B4galt2"
                     /note="beta-1,4-galactosyltransferase 2"
                     /db_xref="GeneID:313536"
                     /db_xref="RGD:1305358"
     exon            1..138
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    125..127
                     /gene="B4galt2"
                     /note="upstream in-frame stop codon"
     exon            139..494
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1300
                     /gene="B4galt2"
                     /EC_number="2.4.1.38"
                     /note="UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
                     polypeptide 2"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 2"
                     /protein_id="NP_001101435.1"
                     /db_xref="GeneID:313536"
                     /db_xref="RGD:1305358"
                     /translation="MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSR
                     FSTRSPAHALYPAASSSTNCSRPNTTAASSGLPEVPSARPGPTAPVIPPCPDVPPGLV
                     GRVVIEFTSPMPLERVQRENPGVLLGGRYSPPDCTPAQTVAVIIPFRHREHHLRYWLH
                     YLHPMLRRQRLRYGVYVINQHGEETFNRAKLLNVGFLEALKEDATYDCFIFSDVDLVP
                     MDDRNLYRCGDQPRHFAIAMDKFGFRLPYASYFGGVSGLSKAQFLRINGFPNEYWGWG
                     GEDDDIFNRISLTGMKISRPDVRIGRYRMIKHDRDKHNEPNPQRFNKIQNTKMSMKWD
                     GIGSVRYRVLEVSRQPLFTNITVDIGQPMSWLTQG"
     misc_feature    614..1264
                     /gene="B4galt2"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    614..1264
                     /gene="B4galt2"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    order(629..631,635..637,641..643,746..748,827..835)
                     /gene="B4galt2"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(629..631,635..637,641..643,746..748,827..835)
                     /gene="B4galt2"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(827..829,833..835,1112..1114)
                     /gene="B4galt2"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(827..829,833..835,1112..1114)
                     /gene="B4galt2"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     exon            495..730
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..921
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1044
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1149
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..2143
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttgtaca gtgagggttt gtgtgcatgt ctaggtggct tagtgctggg gtgtgcctag
       61 gatagcagac actgagtcgc cagcggctgc tggtgtgtct gcaggtagaa tagaaacaag
      121 ccggtgagtg tttgaaaggc tggcagccgg atgcttggtc ccattgggcg ggccattggc
      181 cacctgcggg atgagcagac tgctgggggg tacgctggag cgggtctgta aggctgtgct
      241 ccttctctgc ctgctgcact tccttgtggc tgtcatcctc tactttgacg tctacgccca
      301 gcacctggcc tttttcagcc gcttcagtac ccgaagccca gcccatgccc tctaccctgc
      361 agccagcagc agtaccaact gctctcggcc caacaccact gctgccagct ccgggctccc
      421 tgaagtgccc agtgccaggc ctggccccac agctccagtc attccaccct gtcctgatgt
      481 gccgcctggt cttgtgggcc gagtggtcat cgaattcacc tcacccatgc ctctggaacg
      541 ggtgcagagg gagaacccag gcgtgctcct gggcggccgc tattctccac ctgactgcac
      601 cccagcccaa acggtggcag tcatcatccc ctttagacac cgggagcacc acctacgcta
      661 ttggctccac tatctgcacc ccatgttgag gcgacagcgg ctgcgctacg gtgtctatgt
      721 catcaaccag catggcgagg agaccttcaa ccgagccaag ctgctcaacg tgggcttcct
      781 agaggcactg aaagaggatg ccacctatga ctgcttcatc ttcagtgatg tggacctggt
      841 ccctatggat gaccgcaatc tgtaccgttg tggtgaccag ccccgccact tcgccattgc
      901 catggacaag tttggcttcc ggttgcccta tgccagctac tttggaggtg tgtcaggcct
      961 gagcaaggcc cagtttctga ggattaatgg ttttcccaac gagtactggg gctggggcgg
     1021 cgaggacgat gacatcttca accggatctc cctgactggg atgaagatct cacgcccaga
     1081 cgtccggata ggccgctacc gcatgatcaa gcacgaccgg gacaaacata acgagcccaa
     1141 ccctcagagg tttaataaga ttcaaaacac aaagatgagc atgaagtggg acggcattgg
     1201 atccgtgcgg taccgcgtct tggaagtatc tcggcaacca ctcttcacca acatcacagt
     1261 ggacattggg cagcccatgt catggctcac tcaaggctga cactaacgga caaaggccct
     1321 ccatgccctt ctggtatgga aggctgcctg ccagaggact gacctataac ctggctgaca
     1381 gctgctctag gggtgtcccc aagactgaga ctgtgagctg ttttctgagt cttaatagcc
     1441 agcgcaccta gaagtttcag aactcacttt gaggggcgtt tgggcaagcc cctcttacgg
     1501 ccctctctgg ggtcaaccct tcttcctgtc ctacttttcc cagcccaaac ctcctcactg
     1561 ttagggttgg gccagcccct gcactgcctc gcggagtggc ctgagctagg tcactccacc
     1621 tctctgtgcc tcagtttccc cactcccctc gagtccccta gggcctggaa aggtgggagg
     1681 tttaactagg gggcaatgtc tcttccaggg gggaattctc agatctggag acccctcatg
     1741 cttccagggg aggggaaacc tttttcattc aatattgtag ggggcaagct ttggcaagcc
     1801 acctactgag gagcgccccc aggaggggac cagaaggggt gctgtgttgt ttcctgggat
     1861 catggggttg gcctttgcat gggggacagg tgggcctgga tcagtcagtg gttctggcct
     1921 ccctccctta gagaggaggc aggagcccca gggcctactc tgtttttatg ttgcacagaa
     1981 acttgtgtgg gtgctttagt aaaaaacgtt aacggagcag ctccttgtct gtttgtgaaa
     2041 gggatctggt tccctgaagc tagtttgtgt tgtgggaggt gacctgggta ggggtcttct
     2101 agtgacttaa taaatttcct agccccgtcc tagggggaaa gtt
//
LOCUS       NM_001436821            1193 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus zinc finger, MYND-type containing 12 (Zmynd12),
            transcript variant 3, mRNA.
ACCESSION   NM_001436821 XM_063287741
VERSION     NM_001436821.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287741.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29786.1,
                                           SRR26360181.3044217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000005.1  138312324-138312458
            136-277             JAXUCZ010000005.1  138324301-138324442
            278-449             JAXUCZ010000005.1  138327713-138327884
            450-619             JAXUCZ010000005.1  138333334-138333503
            620-731             JAXUCZ010000005.1  138339497-138339608
            732-877             JAXUCZ010000005.1  138341575-138341720
            878-1193            JAXUCZ010000005.1  138344954-138345269
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1193
                     /gene="Zmynd12"
                     /note="zinc finger, MYND-type containing 12"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
     exon            1..135
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1000
                     /gene="Zmynd12"
                     /note="isoform c is encoded by transcript variant 3; zinc
                     finger MYND domain-containing protein 12; zinc finger,
                     MYND domain containing 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform c"
                     /protein_id="NP_001423750.1"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
                     /translation="MNVIYPLAVPKGRRLCCEVCEAPAERMCTACTVTYYCGPVHQKA
                     DWGSIHAKICQLLIPLRTSMPFFNSEEERQHGLQQLQRRQEHLIEFCYTVAQKYLFEG
                     RHEDAVPAALHSLRFRMNVHGLSSVELVPAYLLLAEASLGLGRIVQAEEYLSQAQWTV
                     LKSTDCSNATHSLLHRNLGLLYIAKKNLEEARYHLANDVSEIWYTYLSSHYQALLHAR
                     TQQTDLLGKQFMNDTGLDEAQEAEAIRILTSILIIQESTSTQAPQKGILILKTLGILY
                     YLMLEFSKAKEYATKALSLAEVYLSEEEQGVIQELLSAILAEEKQLTT"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    254..>610
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    254..>610
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    287..373
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    287..373
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(290..292,299..304,311..316,320..322,416..418,
                     425..430,437..442,446..451,542..544,551..556,563..568,
                     575..577)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(290..292,299..304,311..316,320..322,416..418,
                     425..430,437..442,446..451,542..544,551..556,563..568,
                     575..577)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    386..514
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    386..514
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    <392..916
                     /gene="Zmynd12"
                     /note="MalT-like TPR region; Region: TPR_MalT; pfam17874"
                     /db_xref="CDD:436107"
     misc_feature    <392..916
                     /gene="Zmynd12"
                     /note="MalT-like TPR region; Region: TPR_MalT; pfam17874"
                     /db_xref="CDD:436107"
     misc_feature    539..610
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    539..610
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            136..277
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            278..449
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..619
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            620..731
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            732..877
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1193
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagactgac gccgctggcc acaccatgaa cgtgatctac ccgctggcgg tgcccaaggg
       61 gcgccggctc tgctgtgagg tgtgcgaagc cccggctgag cggatgtgca cggcctgtac
      121 agtcacttat tactgtggtc ctgtgcatca gaaggctgac tggggcagca tccatgcaaa
      181 gatatgccag ctgctgatcc ctctgcgcac cagcatgccc ttcttcaact cagaggagga
      241 gaggcagcat ggtctgcagc agctgcagag gcggcaggag cacttgattg aattctgcta
      301 cactgttgcc cagaaatatc tctttgaagg aagacatgaa gatgccgtcc ctgcagcttt
      361 gcactccctt cgcttccgca tgaatgtgca tggcctgagc tcagtcgagc ttgtgcctgc
      421 ttacctgctc ctggctgagg ccagccttgg tctgggccgg atagtgcagg ctgaagaata
      481 tctatcccaa gctcaatgga cagtcctcaa gtcaactgac tgtagtaacg ccacccactc
      541 tttactgcat cggaacctgg gccttctcta catagccaag aagaacctcg aggaagcccg
      601 gtaccatctg gctaatgatg tctcggagat ttggtacaca tatctgagca gtcactatca
      661 agccctcttg catgctcgta cccaacagac agatttactg ggcaaacagt ttatgaatga
      721 caccggcttg gatgaagccc aggaagcaga agccattcgg atcctaactt caatcctgat
      781 cattcaggaa tctacttcca ctcaagcgcc ccaaaaaggc atccttattc ttaagactct
      841 gggcatactt tactatctga tgttggagtt ttcaaaggcg aaggaatatg ccacgaaagc
      901 cctcagtcta gctgaggtgt atctcagtga ggaggagcaa ggggttattc aagagttgct
      961 gagtgccatc ttggctgagg agaagcagct cacgacctag aggccacctt gctggtgctg
     1021 ccgtgggctg tgggctgtgg gctgtgggct gactagtggt gcagagctgc tcacaggtcc
     1081 tctggcctgc tcccacccct ccctggggac cgcctgaggg gctgtgatcc tgtcagctgg
     1141 tgacctagag ctttgggcgc agtgttcaat aaaatttgtt tatcatgacc ttg
//
LOCUS       NM_001107970            1156 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus zinc finger, MYND-type containing 12 (Zmynd12),
            transcript variant 4, mRNA.
ACCESSION   NM_001107970 XM_001073920 XM_233458
VERSION     NM_001107970.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107970.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000005.1  138312324-138312458
            136-281             JAXUCZ010000005.1  138324301-138324446
            282-478             JAXUCZ010000005.1  138327688-138327884
            479-648             JAXUCZ010000005.1  138333334-138333503
            649-771             JAXUCZ010000005.1  138336285-138336407
            772-883             JAXUCZ010000005.1  138339497-138339608
            884-1029            JAXUCZ010000005.1  138341575-138341720
            1030-1156           JAXUCZ010000005.1  138345143-138345269
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1156
                     /gene="Zmynd12"
                     /note="zinc finger, MYND-type containing 12"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
     exon            1..135
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            136..281
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="Zmynd12"
                     /note="upstream in-frame stop codon"
     CDS             184..1080
                     /gene="Zmynd12"
                     /note="isoform 4 is encoded by transcript variant 4; zinc
                     finger MYND domain-containing protein 12; zinc finger,
                     MYND domain containing 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform 4"
                     /protein_id="NP_001101440.1"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
                     /translation="MPAADPSAHQHALLQLRGGEAAWSAAAAEAAGKVHISVFPQEHL
                     IEFCYTVAQKYLFEGRHEDAVPAALHSLRFRMNVHGLSSVELVPAYLLLAEASLGLGR
                     IVQAEEYLSQAQWTVLKSTDCSNATHSLLHRNLGLLYIAKKNLEEARYHLANDIYFAS
                     CAFGTEDVRTSGGYFHLANIFYSLKKMELADTLYTKVSEIWYTYLSSHYQALLHARTQ
                     QTDLLGKQFMNDTGLDEAQEAEAIRILTSILIIQESTSTQAPQKGILILKTLGILYYL
                     MLEFSKLLTGPLACSHPSLGTA"
     misc_feature    205..>846
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    205..>846
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    448..540
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    448..540
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(454..459,466..471,475..477,571..573,580..585,
                     592..597,601..606,697..699,706..711,718..723,730..732)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(454..459,466..471,475..477,571..573,580..585,
                     592..597,601..606,697..699,706..711,718..723,730..732)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    565..657
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    565..657
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    694..780
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    694..780
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            282..478
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            479..648
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            649..771
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            772..883
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1029
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1156
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagactgac gccgctggcc acaccatgaa cgtgatctac ccgctggcgg tgcccaaggg
       61 gcgccggctc tgctgtgagg tgtgcgaagc cccggctgag cggatgtgca cggcctgtac
      121 agtcacttat tactgtggtc ctgtgcatca gaaggctgac tggggcagca tccatgcaaa
      181 gatatgccag ctgctgatcc ctctgcgcac cagcatgccc ttcttcaact cagaggagga
      241 gaggcagcat ggtctgcagc agctgcagag gcggcaggca aagtgcatat ttctgtcttt
      301 ccacaggagc acttgattga attctgctac actgttgccc agaaatatct ctttgaagga
      361 agacatgaag atgccgtccc tgcagctttg cactcccttc gcttccgcat gaatgtgcat
      421 ggcctgagct cagtcgagct tgtgcctgct tacctgctcc tggctgaggc cagccttggt
      481 ctgggccgga tagtgcaggc tgaagaatat ctatcccaag ctcaatggac agtcctcaag
      541 tcaactgact gtagtaacgc cacccactct ttactgcatc ggaacctggg ccttctctac
      601 atagccaaga agaacctcga ggaagcccgg taccatctgg ctaatgatat ttattttgcc
      661 agttgtgcat ttgggacaga agacgtcagg acctcaggag gctacttcca cctggccaac
      721 attttctata gccttaagaa aatggagctg gctgacacac tgtatacaaa ggtctcggag
      781 atttggtaca catatctgag cagtcactat caagccctct tgcatgctcg tacccaacag
      841 acagatttac tgggcaaaca gtttatgaat gacaccggct tggatgaagc ccaggaagca
      901 gaagccattc ggatcctaac ttcaatcctg atcattcagg aatctacttc cactcaagcg
      961 ccccaaaaag gcatccttat tcttaagact ctgggcatac tttactatct gatgttggag
     1021 ttttcaaagc tgctcacagg tcctctggcc tgctcccacc cctccctggg gaccgcctga
     1081 ggggctgtga tcctgtcagc tggtgaccta gagctttggg cgcagtgttc aataaaattt
     1141 gtttatcatg accttg
//
LOCUS       NM_001436802            1413 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 8, mRNA.
ACCESSION   NM_001436802 XM_063287703
VERSION     NM_001436802.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287703.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.22225.1,
                                           SRR26643294.21734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000005.1  123110307-123110428
            123-147             JAXUCZ010000005.1  123118303-123118327
            148-293             JAXUCZ010000005.1  123122432-123122577
            294-455             JAXUCZ010000005.1  123130554-123130715
            456-588             JAXUCZ010000005.1  123131303-123131435
            589-653             JAXUCZ010000005.1  123132010-123132074
            654-726             JAXUCZ010000005.1  123134055-123134127
            727-878             JAXUCZ010000005.1  123138897-123139048
            879-960             JAXUCZ010000005.1  123139751-123139832
            961-1055            JAXUCZ010000005.1  123141269-123141363
            1056-1183           JAXUCZ010000005.1  123146672-123146799
            1184-1413           JAXUCZ010000005.1  123149294-123149523
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1413
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..122
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    93..95
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="upstream in-frame stop codon"
     CDS             114..1247
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform g is encoded by transcript variant 8;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform g"
                     /protein_id="NP_001423731.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MAEPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEM
                     MEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDAD
                     NDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNS
                     EIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEY
                     LPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRF
                     NVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSE
                     RYDFFAQQTRFGKKKYNLHPGVTMKRICPCCPQPLRAPLQGRD"
     misc_feature    657..806
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    657..806
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    975..1109
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    975..1109
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(975..977,1065..1070,1074..1079,1083..1091,
                     1095..1103)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(975..977,1065..1070,1074..1079,1083..1091,
                     1095..1103)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1137..>1196
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1137..>1196
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            123..147
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            148..293
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            294..455
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            456..588
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            589..653
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            654..726
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            727..878
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            879..960
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1055
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1183
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1413
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgttcccgc cgaagcggcg gcggagacag cagcgggagc cccgcggccc aggcgcacat
       61 ccgggttctg gccacgaccc gccgcggcga tgtgacccgg tggcgcggcc aacatggcgg
      121 agccatctgt tgagtcttca agtccagggg gctcagcagc gtcagaggac catgagtttg
      181 atccgtcagc tgacatgctg gttcatgatt ttgatgatga gcgaacatta gaagaagaag
      241 aaatgatgga aggagagaca aacttcagtt ctgaaataga ggatcttgcg agggaaggcg
      301 acatgccaat cgacgagctt ctcagcctct atggttatgg cagcactgtt cagttacctg
      361 aagaggagga ggaggaggaa gaagaggagg aagaaggtga agatgatgaa gatgcggaca
      421 atgatgacaa cagtggctgc agtggggaaa ataaagaaga gaatataaag gattcatcgg
      481 gtcaggagga tgaaactcag tcttccaatg atgatccctc acagtctgtt acttcccaag
      541 atgctcagga aataatccgc ccacgtcgat gtaaatattt tgatacaaat agtgaaatag
      601 aagaagaatc tgaagaagat gaagattata ttccctcaga agactggaaa aaggaaatca
      661 tggtaggctc catgtttcaa gctgagattc cagttggcgt ttgtagatac aaagaaaatg
      721 aaaaagtgta tgaaaatgat gatcagcttc tgtgggatcc agaatattta ccagaagata
      781 aagtgattgt ctttcttaag gatgcatcta gaagaacagg ggatgagaaa ggtgtagaag
      841 caattcctga aggatctcat ataaaagaca atgaacaggc tttatatgaa ttggttaaat
      901 gcagttttga tacagaagaa gccttgagaa gactgagatt taatgtcaaa gcagctcgag
      961 aggaattatc tgtgtggaca gaggaagaat gtagaaattt tgaacaaggg ctgaaggcct
     1021 atgggaaaga ttttcatctg attcaggcta ataaagtccg aacaagatca gttggtgaat
     1081 gtgtagcatt ctattacatg tggaaaaagt ctgagcgtta tgatttcttt gctcagcaaa
     1141 caaggtttgg aaaaaagaaa tataatcttc atcctggtgt aacaatgaag cgcatttgcc
     1201 cttgctgccc acagcctctg agagctccac tacaggggag ggattgagag ccacattcac
     1261 attggagagc ttgctattcc gaataatact taaaactcca gttacctgaa ctccagcgct
     1321 tttaactcct caattgttcg acccgacttt cttcctaagc atttgggatt tcattgataa
     1381 aaataaagat gataatggct atctgtcaca gta
//
LOCUS       NM_001107980            1667 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus R-spondin 1 (Rspo1), transcript variant 2, mRNA.
ACCESSION   NM_001107980 XM_001056937 XM_233520
VERSION     NM_001107980.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Li,J.Y., Wu,X., Lee,A., Zhou,S.Y. and Owyang,C.
  TITLE     Altered R-spondin 1/CART neurocircuit in the hypothalamus
            contributes to hyperphagia in diabetes
  JOURNAL   J Neurophysiol 121 (3), 928-939 (2019)
   PUBMED   30649980
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Szenker-Ravi,E., Altunoglu,U., Leushacke,M., Bosso-Lefevre,C.,
            Khatoo,M., Thi Tran,H., Naert,T., Noelanders,R., Hajamohideen,A.,
            Beneteau,C., de Sousa,S.B., Karaman,B., Latypova,X., Basaran,S.,
            Yucel,E.B., Tan,T.T., Vlaminck,L., Nayak,S.S., Shukla,A.,
            Girisha,K.M., Le Caignec,C., Soshnikova,N., Uyguner,Z.O.,
            Vleminckx,K., Barker,N., Kayserili,H. and Reversade,B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. doi:
            10.1038/s41586-018-0296-7. PMID: 29977062]
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Li,J.Y., Chai,B., Zhang,W., Fritze,D.M., Zhang,C. and
            Mulholland,M.W.
  TITLE     LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food
            intake in the hypothalamus of male rats
  JOURNAL   Endocrinology 155 (2), 429-440 (2014)
   PUBMED   24280058
  REMARK    GeneRIF: These data indicate that Rspo1 and Rspo3 and their
            receptor LGR4 form novel circuits in the brain to regulate energy
            homeostasis.
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Niehrs,C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Ruffner,H., Sprunger,J., Charlat,O., Leighton-Davies,J.,
            Grosshans,B., Salathe,A., Zietzling,S., Beck,V., Therier,M.,
            Isken,A., Xie,Y., Zhang,Y., Hao,H., Shi,X., Liu,D., Song,Q.,
            Clay,I., Hintzen,G., Tchorz,J., Bouchez,L.C., Michaud,G., Finan,P.,
            Myer,V.E., Bouwmeester,T., Porter,J., Hild,M., Bassilana,F.,
            Parker,C.N. and Cong,F.
  TITLE     R-Spondin potentiates Wnt/beta-catenin signaling through orphan
            receptors LGR4 and LGR5
  JOURNAL   PLoS One 7 (7), e40976 (2012)
   PUBMED   22815884
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Carmon,K.S., Gong,X., Lin,Q., Thomas,A. and Liu,Q.
  TITLE     R-spondins function as ligands of the orphan receptors LGR4 and
            LGR5 to regulate Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11452-11457 (2011)
   PUBMED   21693646
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Kamata,T., Katsube,K., Michikawa,M., Yamada,M., Takada,S. and
            Mizusawa,H.
  TITLE     R-spondin, a novel gene with thrombospondin type 1 domain, was
            expressed in the dorsal neural tube and affected in Wnts mutants
  JOURNAL   Biochim Biophys Acta 1676 (1), 51-62 (2004)
   PUBMED   14732490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: EV779428.1, SRR21887622.4007006.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000005.1  142536344-142536394
            52-396              JAXUCZ010000005.1  142540850-142541194
            397-588             JAXUCZ010000005.1  142553443-142553634
            589-738             JAXUCZ010000005.1  142555616-142555765
            739-927             JAXUCZ010000005.1  142556063-142556251
            928-1667            JAXUCZ010000005.1  142556872-142557611
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1667
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="R-spondin 1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
     exon            1..51
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            52..396
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    234..236
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="upstream in-frame stop codon"
     CDS             303..1091
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /codon_start=1
                     /product="R-spondin-1 precursor"
                     /protein_id="NP_001101450.1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
                     /translation="MRLGLCVVALVLSWTHLAVGSRGIKGKRQRRISAEGSQSCAKGC
                     ELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHC
                     EACFSHNFCTKCQEGLYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCS
                     KKRKLCGFRKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRRTPCPEGQKRKKASQG
                     RRENANRHPTRKNSKEPGSNSRRHKGQQQPQPGTAGPLTSVGPT"
     sig_peptide     303..362
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    426..728
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    426..728
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    744..911
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    744..911
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     exon            397..588
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            589..738
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            739..927
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1667
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccggg cggcggactg cggggcccgc gcgggccgcc ccagcaccaa tgtctgtctt
       61 gagggtggtt ctctgctggc gtgagaagac ttctcatgtg accctctgag gtggcttcaa
      121 gcaggacagg acctcccttt ggaccgatgg agaacctggc tccattcccc ctcagatccc
      181 agctgaggtt atggtggatc tggcctgcag cctgggcctg ggtcccctgc cactgaccca
      241 gcctcagagc ctatagcaag agaccacccc tcctgcaagg ggcccggggc tggccagtga
      301 ctatgcggct tgggctgtgt gtggtggccc tggttctgag ctggacacac ctcgctgtgg
      361 gcagccgggg gatcaagggc aagagacaga ggcggatcag tgctgagggg agccaatctt
      421 gtgccaaggg ctgtgagctc tgttcagaag tcaacggttg cctcaaatgc tcgcccaagc
      481 tcttcattct gctggagagg aacgacatcc gccaggtggg cgtctgcctg ccgtcctgcc
      541 cgcctggata ctttgatgcc cgcaaccccg acatgaacaa atgcatcaaa tgcaagattg
      601 agcactgtga ggcctgcttc agccacaact tctgcaccaa gtgtcaggag ggcttgtact
      661 tacacaaggg ccgctgctat ccagcctgtc ccgagggttc cacagcagcc aacagcacca
      721 tggagtgcgg cagtcctgca caatgtgaaa tgagcgagtg gtcaccgtgg ggcccctgct
      781 ccaagaagag gaagctgtgt ggtttccgga agggatcgga agagcggaca cgcagggtgc
      841 tccatgctcc tggaggagac caaaccaact gctcagacac caaagagacc cggaagtgta
      901 ccgtgcgcag gacgccctgc cctgaggggc agaagaggaa gaaggcgagc cagggccgga
      961 gggagaatgc caataggcac ccgaccagga agaacagcaa ggagccaggc tccaactctc
     1021 ggagacacaa aggccagcag cagccacagc cagggacagc agggccactc acatcagtag
     1081 gccccaccta ggcacagtga ccagtctcca gttacgtgtg gaagaatcca gtgctgtgag
     1141 aactttccag aactggagca tctgggaaag aaagtccaca cataccccat tcacccaccc
     1201 atccatctat ccatgcatcc atgcacacat atggccacat ctgaaaactt ccacacacgc
     1261 gcgcacacac acacacacac acacacacac acacacacac acacacacac acacacactc
     1321 ttgaggtcac agaagatatt tccattctgt ggcccagctg tatattcagc ctaggatgct
     1381 cttagaaggc gtaactgaga gaacctttcc cagcacctga agctaaactt caatgcgtgg
     1441 aaccttctgg aggaacttct gggacagcat ctgccagatg gacggcagat tggaaccaaa
     1501 actggagcag ctgccgaggg gaagaatgct ctccctgtcc tgagaggcac tcccagcttc
     1561 gagacttgat tgttggagaa tcattacaca tccggggtgc acgtcacggc tgacctgact
     1621 tggaaactgc gtaaaggttt atttcaaatt aaaaagagag aaacaaa
//
LOCUS       NM_001436833            3663 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 2, mRNA.
ACCESSION   NM_001436833 XM_006239183
VERSION     NM_001436833.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3663)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3663)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3663)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006239183.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14616.1,
                                           SRR26643298.29590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1647           JAXUCZ010000005.1  152852539-152852683 c
            1648-1689           JAXUCZ010000005.1  152852153-152852194 c
            1690-1815           JAXUCZ010000005.1  152850411-152850536 c
            1816-2277           JAXUCZ010000005.1  152847583-152848044 c
            2278-2473           JAXUCZ010000005.1  152846792-152846987 c
            2474-2683           JAXUCZ010000005.1  152844978-152845187 c
            2684-3663           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3663
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2791
                     /gene="Srrm1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 2"
                     /protein_id="NP_001423762.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRS
                     HVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSRRRRSPSPPPA
                     RRRRSPSPAPPPPPPPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPS
                     PPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSS
                     PGRSTREARSPQPNKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRV
                     SRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSP
                     AAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVA
                     TPAPAAPAAVSAAATPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRK
                     AQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    1157..>2200
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1157..>2200
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    <1892..2479
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1892..2479
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1647
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1689
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1815
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2277
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2473
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2683
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..3663
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgactctggc tcctcttcca cctcagaaga tgagcggccc aagagatccc atgtgaagaa
     1561 tggtgaggta ggcaggcggc ggagacattc tccttctcgg agtgcctctc catcacctcg
     1621 aaagcgccaa aaagagactt cccctcggat gcagatggga aagcgatggc agtcgccagt
     1681 gactaaaagt agaaggagga gaagtccttc cccacctcct gccagaagac gacgatctcc
     1741 ttctccagcc cctcctcccc ctcctccccc acctcctcgg cggcgcagat ctcccacccc
     1801 accaccacga cgaaggaccc cttctcctcc cccacgccgc cgctcaccgt ctccaagaag
     1861 atactctcct cccatccaga ggagatactc tccttcccca cctccaaaga ggagaactgc
     1921 ctcgccccca cccccaccca agcgaagggc atcgccatct cctccaccaa agcgccgggt
     1981 ttcccactct ccacctccta aacaaagaag ccccccagtc accaagagac gctcaccctc
     2041 cttatcttca aagcatagga aagggtcttc cccaggccgc tccactcggg aggcccggtc
     2101 accacaacca aacaaaaggc actcgccctc accacgacct cgggcgcctc agacctcaag
     2161 ccctccccct gttcgaagag gagcttcagc gtctccccaa ggaaggcagt ccccgtctcc
     2221 gagtactagg cctattagga gagtctccag gactccggaa cccaaaaaga taaaaaaggc
     2281 tgcctcacca agccctcagt ccgtaagaag ggtttcatct tcccgctctg tctctggatc
     2341 tcctgagcca acagctaaaa agcctccagc acccccctct cctgtgcagt ctcagtcacc
     2401 ctccacaaac tggtcacctg cagcaccagc caagaaggct aaaagcccaa caccaagccc
     2461 gtcccctgcc aggaattctg atcaagaagg aggtggaaag aagaagaaga agaagaagga
     2521 caagaaacat aagaaggata agaaacacaa gaagcacaaa aaacacaaga aggagaaggc
     2581 tgtggccgta gccaccccag ctcctgctgc ccctgcagct gtctctgctg ccgccactcc
     2641 atcagcccag gaagagcctg cggcagcacc agagcccagg aaggagactg agagtgaagc
     2701 tgaagatgac aaccttgatg acttagagag gcaccttcgg gagaaggccc ttcgatccat
     2761 gcggaaggcc caagtgtccc cacagtccta ggcggacatg tttgttacgt tgtaaatttt
     2821 atttggtttg tactcaattc aatttcaaaa ttgctaaaat gtgtttgagc tttagactat
     2881 aacatttgtt gtaataattg ctaggttgaa gttcaccatg ttaaaaaagg ggggcatgga
     2941 tttacattac aaaggtgtcc acggtgtatt agtgacaatt cttccattga catttagagt
     3001 gaaatatttt aagccaaaaa aaaatctctt ttttaaaaaa gggggtttga atattgttgg
     3061 catttttgtg gttcctttaa atgccctcgc ctctcccaaa aggttggggt cttttctttt
     3121 tctccctatt ctcttgaatc ttagcaccca tgtaaattat gcttccaacc ttgtataggt
     3181 ttgtaagctt gcccagaagt gagagcactg ttgaagtacc acagaggttt gggcgagtga
     3241 gtgttgactc tgttgcccat ggagtctgct gtcctggcag catcccagct ctagagcgcc
     3301 gcactcctga gctacagggc tgccccatgg aacagttcct aaactgacta ggaactctgg
     3361 gttttctcct tccggttgtg ttgttttgtt tccttctccc cttttcttcc tcttttgtaa
     3421 aggcgattca ctagacccag gaaggaccct tcagttacat aaatttgttt tatgaaacat
     3481 ggtggctccc attcatggtt tcccttactc ttccaattgg tacacacaac tgaggagctc
     3541 ctgtatttgg ccggctggaa gggcctggac agtgtcttga tttcacttgt tttattttat
     3601 tttatttttt aactaaagct atataaagct tgtggattaa acagaataaa tttctaaatt
     3661 taa
//
LOCUS       NM_001436787            3421 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 14, mRNA.
ACCESSION   NM_001436787 XM_063275203
VERSION     NM_001436787.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3421)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3421)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3421)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275203.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1162           JAXUCZ010000016.1  19544907-19545047
            1163-1327           JAXUCZ010000016.1  19545145-19545309
            1328-1607           JAXUCZ010000016.1  19546706-19546985
            1608-1909           JAXUCZ010000016.1  19548553-19548854
            1910-2102           JAXUCZ010000016.1  19549883-19550075
            2103-3421           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3421
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2233
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 5 is encoded by transcript variant 14; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 5"
                     /protein_id="NP_001423716.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQVSQIHNIRQHSSTGPPPLLLAPRASVPS
                     MQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVA
                     SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV
                     QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKA
                     LKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQTSSQLSRG
                     SATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSERVVGTSKGTASNWKKTPLSTGG
                     TLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1664..1765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1664..1765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1162
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1327
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1607
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1909
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2102
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..3421
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc caggtgagtc agattcacaa catcagacag cattcctcca cggggccacc
     1201 acccctcctc ctggcccccc gtgcctcagt gcccagcatg cagattcagg gacagaggat
     1261 catccagcag ggactcatcc gggtcgccaa tgtccccaac accagtctgc tcgtcaatat
     1321 ccctcagcct acggcagcct cactgaaggg gacaacagtt ggctctgctc aggcaaactc
     1381 cactcccagc agtgtggctt ctgtggttgc ctctgctgag tccccagcta gccggcaggc
     1441 tgctgccaag ctagcgctgc gcaagcagtt ggagaagaca ctgctggaga tccccccacc
     1501 caagccccct gctccggaga tgaacttctt gcccagtgct gccaacaatg aattcatcta
     1561 tctggtcggc ttggaggaag tggtgcagaa cctgctggag acgcaagcgg gcaggatttc
     1621 tgccacctca gctgctgccg tgttatcccg ggagccttac atgtgtgtgc agtgtaagac
     1681 agacttcaca tgccgctggc gagagaaggg tggagctgtc atgtgtgaga actgcatgac
     1741 atccaaccaa aagaaggcac taaaagtgga gcacaccagt cgcctgaagg ccgccttcgt
     1801 gaaggcgcta caacaagagc aggagatgga gcagcgactg ctgcagcagg gcgtaggcac
     1861 cgccagcatc aaggctgaga ccgcagctcc acatccctcg ctgaagcaga cttccagcca
     1921 gctgtcccgg ggttcagcca caacacctcg tggtgttctg cacactttca gccagtcacc
     1981 caaactgcag aacgcagcct cagctacggc cctggtaagc aggactggca gacattccga
     2041 gagagtcgtg ggcaccagca agggcaccgc ctccaactgg aaaaagacac ctctgagcac
     2101 aggtgggacg cttgccttcg tcagcccaag cttggcagtg cacaagagct cctcggccgt
     2161 ggaccgacag cgagagtacc tcctggacat gattcctcca cgctccatcc cccagtcagc
     2221 cacatggaaa tagtgggagc cggcccagcc gaggacaggc cctctgctct cccgaggccc
     2281 ttggtctagg acacgcagac taccctccta gcaagttgcc tgagacagct caggccttgg
     2341 ctcttgcctt gctgtggcca ggagagtacc accatggtgc ccaggatcag aaccagggac
     2401 cttccctatg ggccttctcc ttcctttttg cctttagttt gcccgacacc agcagaaact
     2461 cggaccttgg ggccagctct gcctggccag cgtgggtggg agctcaccct ggacactgtg
     2521 acacacccgg gccagactgg caccgggggc tcccgaagtt gagccgggat ttcgttttct
     2581 tttggctttt cccatcttag ctccccagtc tctgcctctt catggccatc tataggttga
     2641 agtttgggtt ttattgggtt ttttgttttt gtttttttta taatcacctc ataatgatga
     2701 tggaattaaa gtgaactgca tagacccagg gtcatggttg tgcacagtgc agtctggcag
     2761 gctctacccc agaggatgct cagagtggca gcagcagaga tggcaggtgc caccctggct
     2821 ctggtcgtgt ttgttgctgc tcactgcagt ccctggcttc cacacttagc agaatgaacc
     2881 gcagcccaga tctgtctgac atccagaggc tccagaggga tgctggggtc cgccatgctg
     2941 gagtcagagc tgactgctgg ctgggaggct gctgggttac ttttcgtggt ttattttatt
     3001 aaaaatttct atcctttttc tcttcatttt gatggacaca atctcaagat gcccatgcct
     3061 gccaagaggc atccaagtag ggcccagcca gaacccttag gtctggagtc agcagggctt
     3121 actccctctt agccacaggg atgtctgaaa gggctgagtc tacttttgtt ctgttttgtt
     3181 tccttctccc tccactctta acaatgggtt ccatggtgaa aggcagaagc agctctgtgt
     3241 ccagcacgca cggtgcggcc ttctgctcat gtgattggtc gccgtcgttt ccccatccag
     3301 ccctggtttc ccttgacaca atacagttag ggactttaat ttaaaccctt gttctgcaga
     3361 ccatcgccct ctgcagacat gcccctgcct cctcctaata aaggctcatt taactccgtg
     3421 a
//
LOCUS       NM_001436822            1098 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus zinc finger, MYND-type containing 12 (Zmynd12),
            transcript variant 5, mRNA.
ACCESSION   NM_001436822
VERSION     NM_001436822.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.388059.1,
                                           SRR22399484.1657513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000005.1  138312324-138312458
            136-277             JAXUCZ010000005.1  138324301-138324442
            278-449             JAXUCZ010000005.1  138327713-138327884
            450-1098            JAXUCZ010000005.1  138333334-138333982
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1098
                     /gene="Zmynd12"
                     /note="zinc finger, MYND-type containing 12"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
     exon            1..135
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..637
                     /gene="Zmynd12"
                     /note="isoform 5 is encoded by transcript variant 5; zinc
                     finger MYND domain-containing protein 12; zinc finger,
                     MYND domain containing 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform 5"
                     /protein_id="NP_001423751.1"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
                     /translation="MNVIYPLAVPKGRRLCCEVCEAPAERMCTACTVTYYCGPVHQKA
                     DWGSIHAKICQLLIPLRTSMPFFNSEEERQHGLQQLQRRQEHLIEFCYTVAQKYLFEG
                     RHEDAVPAALHSLRFRMNVHGLSSVELVPAYLLLAEASLGLGRIVQAEEYLSQAQWTV
                     LKSTDCSNATHSLLHRNLGLLYIAKKNLEEARYHLANDVSERP"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    254..>610
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    254..>610
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    287..373
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    287..373
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(290..292,299..304,311..316,320..322,416..418,
                     425..430,437..442,446..451,542..544,551..556,563..568,
                     575..577)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(290..292,299..304,311..316,320..322,416..418,
                     425..430,437..442,446..451,542..544,551..556,563..568,
                     575..577)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    386..514
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    386..514
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    539..610
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    539..610
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            136..277
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            278..449
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..1098
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagactgac gccgctggcc acaccatgaa cgtgatctac ccgctggcgg tgcccaaggg
       61 gcgccggctc tgctgtgagg tgtgcgaagc cccggctgag cggatgtgca cggcctgtac
      121 agtcacttat tactgtggtc ctgtgcatca gaaggctgac tggggcagca tccatgcaaa
      181 gatatgccag ctgctgatcc ctctgcgcac cagcatgccc ttcttcaact cagaggagga
      241 gaggcagcat ggtctgcagc agctgcagag gcggcaggag cacttgattg aattctgcta
      301 cactgttgcc cagaaatatc tctttgaagg aagacatgaa gatgccgtcc ctgcagcttt
      361 gcactccctt cgcttccgca tgaatgtgca tggcctgagc tcagtcgagc ttgtgcctgc
      421 ttacctgctc ctggctgagg ccagccttgg tctgggccgg atagtgcagg ctgaagaata
      481 tctatcccaa gctcaatgga cagtcctcaa gtcaactgac tgtagtaacg ccacccactc
      541 tttactgcat cggaacctgg gccttctcta catagccaag aagaacctcg aggaagcccg
      601 gtaccatctg gctaatgatg tgagtgaacg cccttaagac acctgggtat tcccaagaat
      661 ggttctgctc agggtttctt taactgagca tctctctaac acttactgct tatactgacc
      721 atctggggag cagcagcaag aactcagctc taataacctc agttcaagcc tttctacttc
      781 ctgacgatgc aaatgtagcc aggccccatc tcttcccctc tccccctcag cggtctgagg
      841 ctaatctgaa aagacagagc tgcacagcgc taagagaagt ttttttccgg ctctgctagt
      901 tctgtgacaa attatttaac cttttccatc gcatgtaaga cacaaatcat aaactggccc
      961 ccaccacatc agcgcattgc agagatcaat aacagaagac tgtacgcact ggactttgtg
     1021 gctatctgtt aaaataatat taacgtctct tcttcagagt gtggttatta aatttaaatg
     1081 agtcagatct ataagaaa
//
LOCUS       NM_001436800            4679 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 6, mRNA.
ACCESSION   NM_001436800
VERSION     NM_001436800.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4679)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4679)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4679)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.23488.1,
                                           SRR26643287.13617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  123105380-123105468
            90-190              JAXUCZ010000005.1  123106498-123106598
            191-225             JAXUCZ010000005.1  123109200-123109234
            226-250             JAXUCZ010000005.1  123118303-123118327
            251-396             JAXUCZ010000005.1  123122432-123122577
            397-558             JAXUCZ010000005.1  123130554-123130715
            559-691             JAXUCZ010000005.1  123131303-123131435
            692-756             JAXUCZ010000005.1  123132010-123132074
            757-829             JAXUCZ010000005.1  123134055-123134127
            830-981             JAXUCZ010000005.1  123138897-123139048
            982-1063            JAXUCZ010000005.1  123139751-123139832
            1064-1158           JAXUCZ010000005.1  123141269-123141363
            1159-1286           JAXUCZ010000005.1  123146672-123146799
            1287-1426           JAXUCZ010000005.1  123150654-123150793
            1427-4679           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4679
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..89
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            90..190
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="upstream in-frame stop codon"
     exon            191..225
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            226..250
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            251..396
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1755
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform e is encoded by transcript variant 6;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform e"
                     /protein_id="NP_001423729.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLS
                     LYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQ
                     SSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSM
                     FQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIP
                     EGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAY
                     GKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMD
                     RLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEV
                     KVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAK
                     RRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND"
     misc_feature    760..909
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    760..909
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1078..1212
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1078..1212
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1078..1080,1168..1173,1177..1182,1186..1194,
                     1198..1206)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1078..1080,1168..1173,1177..1182,1186..1194,
                     1198..1206)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1240..>1680
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1240..>1680
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            397..558
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            559..691
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            692..756
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            757..829
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            830..981
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1063
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1158
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1286
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1426
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..4679
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgag tctcccggct gcaggcggat ggatggggcg tctccaggcg gcggcggcag
       61 cagcggaggc ggcggtagcg gcggcggcta tggtgtggtg gctcgattct cccagtgcct
      121 ggctgagttt cggacgtggt taagaaccaa ctggttgagg ttcaatgcag acaagacgga
      181 tgtgatgctg actgtctctg gattcttttc ctgtcaaatt acaagccatc tgttgagtct
      241 tcaagtccag ggggctcagc agcgtcagag gaccatgagt ttgatccgtc agctgacatg
      301 ctggttcatg attttgatga tgagcgaaca ttagaagaag aagaaatgat ggaaggagag
      361 acaaacttca gttctgaaat agaggatctt gcgagggaag gcgacatgcc aatcgacgag
      421 cttctcagcc tctatggtta tggcagcact gttcagttac ctgaagagga ggaggaggag
      481 gaagaagagg aggaagaagg tgaagatgat gaagatgcgg acaatgatga caacagtggc
      541 tgcagtgggg aaaataaaga agagaatata aaggattcat cgggtcagga ggatgaaact
      601 cagtcttcca atgatgatcc ctcacagtct gttacttccc aagatgctca ggaaataatc
      661 cgcccacgtc gatgtaaata ttttgataca aatagtgaaa tagaagaaga atctgaagaa
      721 gatgaagatt atattccctc agaagactgg aaaaaggaaa tcatggtagg ctccatgttt
      781 caagctgaga ttccagttgg cgtttgtaga tacaaagaaa atgaaaaagt gtatgaaaat
      841 gatgatcagc ttctgtggga tccagaatat ttaccagaag ataaagtgat tgtctttctt
      901 aaggatgcat ctagaagaac aggggatgag aaaggtgtag aagcaattcc tgaaggatct
      961 catataaaag acaatgaaca ggctttatat gaattggtta aatgcagttt tgatacagaa
     1021 gaagccttga gaagactgag atttaatgtc aaagcagctc gagaggaatt atctgtgtgg
     1081 acagaggaag aatgtagaaa ttttgaacaa gggctgaagg cctatgggaa agattttcat
     1141 ctgattcagg ctaataaagt ccgaacaaga tcagttggtg aatgtgtagc attctattac
     1201 atgtggaaaa agtctgagcg ttatgatttc tttgctcagc aaacaaggtt tggaaaaaag
     1261 aaatataatc ttcatcctgg tgtaacggat tacatggatc gtcttttgga tgaaagtgaa
     1321 agtgctgctt ctagccgagc accatcccct cctcccaccg cctcaaacag tagtaccagc
     1381 cagtcggaga aagaagacgg cacgctcagc aatagcaatc agaatggtgt gtcatctaat
     1441 ggaccaggag aaatactaaa caaagaagaa gtaaaagttg aaggcttaca tgttaatgga
     1501 ccaacaggtg gaaataagaa accacttctt acagatgtgg acactaatgg ttacgaagaa
     1561 aataaccttg ccactgaccc aaaacttgcc catatgactg caagaaatga aaatgatttt
     1621 gatgaaaaaa atgagagacc tgccaaaagg cggcggataa acagcagtgg gaaagaaagt
     1681 ccgggttcgt ctgagttttt ccaggaagca gtctcacatg ggaagtttga ggaacatgaa
     1741 aacacaaatg actaactctt aggcctattt tactttcttt gcagtaaagt ctggtttgac
     1801 tacaattttc agggttgggg gggtgacctt tagaaagctg atttccttga agcagttgtt
     1861 aactcttgaa attggaatta ggtcctaact ttaagaaatg ggattcataa ttctactttt
     1921 tgcaagttct tttacttcaa attttgaagc cctctttaag gatataaaaa cattggtaaa
     1981 tttgaatgac ccaaagactt aactgcacct tctcctttga gaaacaagtc atatttgact
     2041 aaaaggtaat ctttccttat tctttatgag gaagaaaaaa gtttgtttct gttcaacacc
     2101 aatttttttt attatctaga aatgtcttta caacagacat ttttctctcc atacaaattg
     2161 aacatcgtca ttaaggaaac cctcatgaat cctgaaggtt atgctagcat gatttttata
     2221 tgtagaagtt taaaaataaa ccaagtcagg tttgtatttg taaaattgtt gacatcaatg
     2281 atgtctttcc atattcttat ctgggcttaa gaaatacatt ctgtattttt ccagattctt
     2341 tgtagccttt gaaagatttt tacagtacat atgtcttgac tgagctgtcc tttcttaata
     2401 caaaaaaagc ttgtataatt ttcttaactt gtacagttgg taaactttta tgagaggaac
     2461 tgatattctg agtctgtcag ctttcatttt attttgctaa gatttttcta atgaattttt
     2521 aagtgtgtgt gtagttaacc aagtcatgtt tcttatccag gtggtaaaag cattcataaa
     2581 gaattatgtt attttcaaac ttctacttac tgacataatt tgggacttct aaatttcagc
     2641 atgatactca gattacaagc ttgtttgcat ttgctataat tttataaatt aattgtgaaa
     2701 caaaacaaag acttactgtc agcttaagtg tgtagatgta tcgtgctgaa tagaatcctg
     2761 ttcagttact ctcatgtgcc ctacaagatt tctcattgtt tcagtcaaca gaaagggaag
     2821 gtcacgtgat gttgcaatat tgccacatcc aaggagtaac tgttgacagg tagcaatatt
     2881 catttttatg agaaaatagt ggttttaaga attttcagat ctttccagtt gtaatccagt
     2941 ttgtcacatt tgatactttt tccaaaatga aacacataca aaataaccat tgttctgtgt
     3001 gactttaaaa agggttattg cactagcctt gtaagaatgg atgccatttt attgttagtg
     3061 caaaattctt cttacaaaat gtagttttat acagctgata gaccaatcta tctctggact
     3121 gttttttagt gaatgatgat taactacctt ttctcacaca ggcacatccc caaatgctgc
     3181 cttcagtttg atctcagccg tcagttcaag agccactgct ttcaaagaca gatctgtgtc
     3241 cttttagtgg ctcagttgtc tgatgcaggg tgggttaagg tttgcactga gaatgatcgc
     3301 ccaggcctct ccctcatagt attcttacat ttgtccagac tgcttccctt cacaatgggt
     3361 acaaactttt ctttccccaa atcagtatta gaagccacct tgacagcaca tcataataat
     3421 acgcatttac tgttttctgc agaaatagtc cagtgagttg ccttcaggtg gaagtgctga
     3481 gaagcacgag agggtttagt ttgttttatt gaaaacatta atttatccag aatggcagta
     3541 ggtcaagtac ctttagcaga tggtcatagc ttgtctccct gcccaccccc acagagtctc
     3601 actgtgtagc ccaggctggc ctggaactta acaacccttc tacctcagcc cgctaatgct
     3661 gagattggag gtgtttccca ccacacccag caacagtcta ttttctaaag caggttttat
     3721 tatatgagtc caggccatcc cagctccttg tcacaggtga tctttaagtg atgctatgct
     3781 ttttaatcat tacactatgg aagatgtcag tccgcctttt aaaggatgcc tctgctcgac
     3841 acgttcttgg acttctcgaa actgttgtaa caggaacgtt ttaaggaaat tctcaggcat
     3901 gttggcaaat gtgccaggtg tataagtgtt cataaatctt ttctttttaa agtatgcata
     3961 atgaaacatt cctctaatac acaaggctca gcttttccca actatattct gtgtttgtat
     4021 aggtatttca ccctttgttc aaaaaatgca gccactgaaa cttaagtcat tgcactttta
     4081 aacagtttga caatatcatg agtaatctgc ttaagatttg gtgtatttcc taactgttga
     4141 acacttaagt aactgagatg agaaaataag cattcatgag tagggatgta gctcagttgc
     4201 tggaatgctt acccaacatg catgcaaaat gggttccatc cccagtacca caggaactgg
     4261 gtatagtggt gcatgcctgt catcctaagc acttgggagg tggaggcagg agaatcagaa
     4321 gttcaaggcc atcctcatta cctggtgagt tgaggccagc ctgatatgct gactcagata
     4381 gaaatggctc tgttggtagt tattaggtcc tagccaagca ctgtcatttt catctggaac
     4441 atacaatgat gatgtattta tgatgtattc tcactaaggt tcacaatctg taactcagtt
     4501 caacacagat ctcttgagct ttaaaaggta tttgaagtaa tttaagtagg cattcaaaat
     4561 tatgaattag atgtttttaa atttctgcat aataattttg cactgtaaaa tatgtccttt
     4621 ctcccatttc cttctgccat tctgatatgc tcattaaaat atttttgtaa gcatactca
//
LOCUS       NM_001436770            1803 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 3, mRNA.
ACCESSION   NM_001436770 XM_017593365
VERSION     NM_001436770.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017593365.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.28362.1,
                                           SRR26643290.19595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1253           JAXUCZ010000005.1  102900532-102900650 c
            1254-1803           JAXUCZ010000005.1  102898944-102899493 c
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1803
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1332
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 3 is encoded by transcript variant 3; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 3"
                     /protein_id="NP_001423699.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEHINPVTEKRIR
                     VEHTSDEDLETDSLD"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    <550..>1278
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <550..>1278
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1253
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1803
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagaagaga
     1141 aagggtggaa gaaacttcca ggctgctcac aggaggaaca tgctaaaagg ccaacatgag
     1201 aaagaagctg cagatcggaa acgcaagcag gaggaacaaa tggagactga gcacattaat
     1261 ccagtaactg aaaagagaat acgagtggag catacaagcg atgaagatct tgagacagac
     1321 tcattggact gaattttccc ctcccccctt gatggaagaa atgttccaga ttctaaattg
     1381 aggacttcac tattaatggc attattaact gtgttatgat tgttaacaaa atatcctgta
     1441 aggtacacac tacatattaa ggttggccat cattcctgtt ttttttttta gccaagctta
     1501 aaatgaagct ttgtgtttga agttataaca aacatagatg aagtcggtgg ttgtacatta
     1561 tttcatttag aaaatatgaa aactcatttt gttttgaaga taggtattaa actgaaatag
     1621 ctattacgtt cttgaaaaat ggggcaggtg tgcccttccc ttgacattct tttgttgtta
     1681 agttctttag agtcttgttt ttttttttct ttttaatcct gagagattaa acagtagact
     1741 tgttaagtaa aaatatgaaa ctgtaaccaa aattttaaaa taaagttttt tttaaaaaaa
     1801 aaa
//
LOCUS       NM_001436786            3327 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 13, mRNA.
ACCESSION   NM_001436786 XM_063275201
VERSION     NM_001436786.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3327)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3327)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3327)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275201.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2189179.1,
                                           SRR26643293.74325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000016.1  19500545-19500690
            147-248             JAXUCZ010000016.1  19508790-19508891
            249-506             JAXUCZ010000016.1  19523772-19524029
            507-639             JAXUCZ010000016.1  19543122-19543254
            640-771             JAXUCZ010000016.1  19543358-19543489
            772-861             JAXUCZ010000016.1  19543675-19543764
            862-993             JAXUCZ010000016.1  19544907-19545038
            994-1158            JAXUCZ010000016.1  19545145-19545309
            1159-1438           JAXUCZ010000016.1  19546706-19546985
            1439-1740           JAXUCZ010000016.1  19548553-19548854
            1741-1815           JAXUCZ010000016.1  19549511-19549585
            1816-2008           JAXUCZ010000016.1  19549883-19550075
            2009-3327           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3327
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..146
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            249..506
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2139
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 4 is encoded by transcript variant 13; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 4"
                     /protein_id="NP_001423715.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAFR
                     SGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSE
                     RVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQ
                     SATWK"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    646..765
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1495..1596
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1495..1596
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            507..639
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            640..771
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            772..861
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            862..993
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1158
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1438
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1740
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1815
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2008
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..3327
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgttcctt tagctcccgt aggagcagaa cctagatacg cttcctccag cttggtgggg
       61 tgaccctcct caagcccctg aaaacaccag gaaatattgg ggagagtctt aggtcttcca
      121 actgccctgc ttaggggggg tcacaggttg gccagcacat tgagccagca catccacata
      181 agttgccttt tgacagagct gtggccatga cggcatggta ggaccagcgt cacggaccct
      241 gaggccagaa tgagtgaaga agcatgccga acccgcagtc agaagcgagc ctttgaacct
      301 gacctaacgg aggatgatgt ggagagcaag aaaatgaaaa tggagagagg accatcagaa
      361 ctgccggtgg atggagacag cagggtgatg ccagagccca gtgcaggccc agcccagggg
      421 ttgctgagga caacagaggc catgggcaca ggatctggcg aagggctgtt aggagacggg
      481 cctgtggaca tgcgtacctc acacagtgac atgaagtctg agaagagacc tccctcgcct
      541 gatgtgattg tgctctctga cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc
      601 acagtggcct tgaaagacac cagcactgag gcgctcttga aaagcagccc agaagagcga
      661 gaacggatga tcaagcagct gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg
      721 ttgaagaagc tgcgacagag tcaaatacag aaggaagcca ctgcccagaa gcctacagct
      781 tcctcaggga gcactgtgac cacccctccc ccactcgtgc ggggtcccca gaacattcct
      841 gctggcaagc catcactcca gacctcctcc actcggatac ccggcagcat catcccacca
      901 ccactggtcc gaggtgggca gcaggtgtct gccaaactgg gaccacaggc cagctctcaa
      961 gtagtcatgc caccacttgt caggggagcc cagattcaca acatcagaca gcattcctcc
     1021 acggggccac cacccctcct cctggccccc cgtgcctcag tgcccagcat gcagattcag
     1081 ggacagagga tcatccagca gggactcatc cgggtcgcca atgtccccaa caccagtctg
     1141 ctcgtcaata tccctcagcc tacggcagcc tcactgaagg ggacaacagt tggctctgct
     1201 caggcaaact ccactcccag cagtgtggct tctgtggttg cctctgctga gtccccagct
     1261 agccggcagg ctgctgccaa gctagcgctg cgcaagcagt tggagaagac actgctggag
     1321 atccccccac ccaagccccc tgctccggag atgaacttct tgcccagtgc tgccaacaat
     1381 gaattcatct atctggtcgg cttggaggaa gtggtgcaga acctgctgga gacgcaagcg
     1441 ggcaggattt ctgccacctc agctgctgcc gtgttatccc gggagcctta catgtgtgtg
     1501 cagtgtaaga cagacttcac atgccgctgg cgagagaagg gtggagctgt catgtgtgag
     1561 aactgcatga catccaacca aaagaaggca ctaaaagtgg agcacaccag tcgcctgaag
     1621 gccgccttcg tgaaggcgct acaacaagag caggagatgg agcagcgact gctgcagcag
     1681 ggcgtaggca ccgccagcat caaggctgag accgcagctc cacatccctc gctgaagcag
     1741 gtcataaagc cccgacgtaa gttggcgttc cgctcaggag aggcccgtga ctggaataac
     1801 gggtccgtac tacagacttc cagccagctg tcccggggtt cagccacaac acctcgtggt
     1861 gttctgcaca ctttcagcca gtcacccaaa ctgcagaacg cagcctcagc tacggccctg
     1921 gtaagcagga ctggcagaca ttccgagaga gtcgtgggca ccagcaaggg caccgcctcc
     1981 aactggaaaa agacacctct gagcacaggt gggacgcttg ccttcgtcag cccaagcttg
     2041 gcagtgcaca agagctcctc ggccgtggac cgacagcgag agtacctcct ggacatgatt
     2101 cctccacgct ccatccccca gtcagccaca tggaaatagt gggagccggc ccagccgagg
     2161 acaggccctc tgctctcccg aggcccttgg tctaggacac gcagactacc ctcctagcaa
     2221 gttgcctgag acagctcagg ccttggctct tgccttgctg tggccaggag agtaccacca
     2281 tggtgcccag gatcagaacc agggaccttc cctatgggcc ttctccttcc tttttgcctt
     2341 tagtttgccc gacaccagca gaaactcgga ccttggggcc agctctgcct ggccagcgtg
     2401 ggtgggagct caccctggac actgtgacac acccgggcca gactggcacc gggggctccc
     2461 gaagttgagc cgggatttcg ttttcttttg gcttttccca tcttagctcc ccagtctctg
     2521 cctcttcatg gccatctata ggttgaagtt tgggttttat tgggtttttt gtttttgttt
     2581 tttttataat cacctcataa tgatgatgga attaaagtga actgcataga cccagggtca
     2641 tggttgtgca cagtgcagtc tggcaggctc taccccagag gatgctcaga gtggcagcag
     2701 cagagatggc aggtgccacc ctggctctgg tcgtgtttgt tgctgctcac tgcagtccct
     2761 ggcttccaca cttagcagaa tgaaccgcag cccagatctg tctgacatcc agaggctcca
     2821 gagggatgct ggggtccgcc atgctggagt cagagctgac tgctggctgg gaggctgctg
     2881 ggttactttt cgtggtttat tttattaaaa atttctatcc tttttctctt cattttgatg
     2941 gacacaatct caagatgccc atgcctgcca agaggcatcc aagtagggcc cagccagaac
     3001 ccttaggtct ggagtcagca gggcttactc cctcttagcc acagggatgt ctgaaagggc
     3061 tgagtctact tttgttctgt tttgtttcct tctccctcca ctcttaacaa tgggttccat
     3121 ggtgaaaggc agaagcagct ctgtgtccag cacgcacggt gcggccttct gctcatgtga
     3181 ttggtcgccg tcgtttcccc atccagccct ggtttccctt gacacaatac agttagggac
     3241 tttaatttaa acccttgttc tgcagaccat cgccctctgc agacatgccc ctgcctcctc
     3301 ctaataaagg ctcatttaac tccgtga
//
LOCUS       NM_001436811            4674 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 6, mRNA.
ACCESSION   NM_001436811
VERSION     NM_001436811.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4674)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4674)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.74846.1,
                                           SRR26360181.3385779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  52866894-52866960   c
            68-176              JAXUCZ010000016.1  52866109-52866217   c
            177-1273            JAXUCZ010000016.1  52848306-52849402   c
            1274-1542           JAXUCZ010000016.1  52836572-52836840   c
            1543-1693           JAXUCZ010000016.1  52822585-52822735   c
            1694-4674           JAXUCZ010000016.1  52818691-52821671   c
FEATURES             Location/Qualifiers
     source          1..4674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..4674
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..67
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="upstream in-frame stop codon"
     exon            68..176
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1821
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 3"
                     /protein_id="NP_001423740.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MWTRLVWTPSEICLPLLSEYWNQRYTFGIMDRFGDISEGEVDHS
                     FFDSDFEDTKKCESNSIFDKQNDDDFKEGINKDIKNLNLKFGVQNDNLKEKIDNDTEN
                     VNVKLGIQTKENYLTQKGNERKPKFPSKEQHVENDPIQTRSPSLLTSSRSKKLCDTTK
                     GNKLHLPVPNRIPKIVKGEDDYYTDGEESSDDGKKYHVRSKSAKPSSNLKKNNTSKKY
                     SKASSSSLSSSSSRSSSDCSDIGSDMQNKPDSGSSGKRVSSVTPSSPKQKCKSGRKSS
                     AKQKAGDYNAESEDNVTDVTPASTPDSSPAQPFELSQSQNQKVKVKRQENVSRDVYED
                     VEALKNDSRCLKSAKRKEKHGQNFAPKSSVLDANLDRRSKQKVLHDTMDLNHLLKAFL
                     QLDKKGPQKHHFEQPSIIPRKNYSFTREEVRQIDRENQRLLKELSRQAEKPGNKSTIP
                     GRSLGHPPKLYHSALNRQREQQRIERENMALLKRLEAVKPTVGMKRSEQLMDYHRNIS
                     YLNPSPSVRRVRSTLGHYSPLRGASRTSSATSGLSCKTDRSVLDTSSGFLLRPKPPNV
                     RTAWL"
     misc_feature    1255..1563
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1255..1563
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            177..1273
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1542
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1693
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..4674
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaccgcg tctgttcgtg gaaaattttg ctgcaggtgt cagaagcttg agtactgctc
       61 ggctcagggt ctctctgtgt aaacctggct atcctgaaac tcactatgtg gaccaggcta
      121 gtctggactc cctcagagat ctgcttgcct ctgctttcag agtactggaa tcaaagatat
      181 acttttggca tcatggatcg gtttggcgat atctcagaag gtgaagtgga ccattctttc
      241 tttgacagtg attttgaaga cacaaagaaa tgtgaaagta attccatttt tgacaagcaa
      301 aatgatgatg actttaagga aggaataaat aaggacatca aaaatttaaa cttgaaattt
      361 ggagtacaaa atgataacct taaagagaaa atagataatg acacagaaaa tgtgaacgtg
      421 aaacttggga tacaaacaaa ggaaaattac cttactcaga agggaaatga aaggaaacca
      481 aaatttccct caaaggaaca acatgtagaa aatgacccta tacaaacaag aagtccctca
      541 ttgttgactt cttcaaggtc aaaaaaactg tgtgatacca caaaaggaaa taaactacat
      601 ttgcctgttc caaatagaat tcctaaaatt gtgaaaggtg aggatgacta ctacacagat
      661 ggagaggaaa gcagtgacga tgggaagaag taccacgtga ggtctaagtc agcgaagccc
      721 tctagtaact taaaaaagaa caacacaagt aagaagtatt ccaaagccag ttcctcctct
      781 ctgtcttcct catcttcacg atcaagctca gactgctcag atataggatc tgacatgcaa
      841 aataaacctg attcaggttc atcagggaaa cgagtttcta gtgtaacccc ctcatcacca
      901 aagcagaagt gtaagtcagg aagaaaatca agtgctaaac agaaggcagg tgactataat
      961 gcagagtcag aagacaacgt aacagacgta actcccgcgt caactccaga cagcagccct
     1021 gcccagccat ttgagttgag ccaatcacag aatcaaaaag taaaagttaa aagacaagaa
     1081 aatgtgagcc gggatgtgta tgaggatgtg gaggctttaa agaatgattc aagatgtctg
     1141 aaatcagcca aaaggaaaga aaagcatgga cagaattttg ctccaaaatc atcagtgtta
     1201 gatgcaaatc tagaccgtag atccaagcaa aaagtcttac atgacacaat ggaccttaat
     1261 catctgttga aagctttcct gcagttagat aaaaagggac cacagaaaca tcactttgag
     1321 cagccttcaa taatacctag gaaaaactac tctttcacaa gagaagaggt gagacagatt
     1381 gatcgggaga atcagaggct tttgaaagaa ctgtcaagac aggctgaaaa accaggaaac
     1441 aaaagtacaa ttcctggaag atcgctcggc catccaccta agttgtatca cagtgctctc
     1501 aacagacaga gggaacagca aaggattgaa agagaaaata tggctttatt gaaacggctt
     1561 gaagctgtga agccaacagt tggcatgaaa cgctctgaac agctgatgga ctaccatcgg
     1621 aatatcagtt acctcaaccc ttcaccgtcc gtcagacgag tgagatctac tcttggccat
     1681 tacagcccac tgagaggagc ttccaggaca tccagtgcaa ccagtggtct cagttgtaag
     1741 actgatcgat cagtgttgga cacatccagt ggctttttgc taagaccgaa acccccgaat
     1801 gttcgtactg cttggttgta aaaccttttt ttatgatata cattgttcat ctgttggtcc
     1861 tgttttaacg atgtattttt ctgtactact ataactattt gcaaacatct gtcatacttt
     1921 tccaacaatt tatacagcaa tgagtataat ttattgttat tcagtgcaaa ttgttatcaa
     1981 aagacacttt gatgtaaaat cagtgtttca tgcagtggca tatttatagg agccatatgt
     2041 ctatttcata gagaaaggtg tatgcatgaa tgtttcttcg atataggaat tcagctgttg
     2101 tgctgacaaa gcagcagtgg tggtaatcca tgttgaaacc aagacgctca ctatatagtt
     2161 cttaatctat atgagtttca gttattgtaa gcgttaaggt gctttacctt gtaaacttaa
     2221 gcgcctcatg cttctgtctg ctttagactg tctgtaacac gagtcagcac ttgcttatgt
     2281 gagtgttcca ctccaaatga aaaaaacttg aaatttgttt tcatggagaa gctggtgtag
     2341 tcttgatgag gagcatgagc agcttgtatc agtgcagctc ttgcttgact aacgacgctt
     2401 ctccctaagt ctgattatct attccaaacc gtttcacccc atgaatgagg ggttcacttt
     2461 agaagcgtct gtttcatgtt tatatgcagt ctggtaaaat acccttaagg attctgaggc
     2521 aagagagagg ctttaacagc ttcgagtctt gtgacttgtg actggtttgg atccagatca
     2581 tttgcatcat taacaaaagc atgtgtttat ggatcaggga gcaacattcc cagcttgaag
     2641 accagggtgt gttagagcag tgtttgaaat gatactgtta gtgtgtgtgc tgtcgttgtg
     2701 tatttattgt attaatagaa tgcttagagt aaggaagaaa tgattagaga aaccaaatac
     2761 aaacaagaaa gaaactaatc acacattggt cacagctact gccttaatgt tagtgaatgt
     2821 ccttggcttg ctttagctga gtcctggaag caccagtctt cagtctcatg tttgaaggtc
     2881 tgttaatcct catggacttg ctagtgaccc acagatgtga aatagttgac tatgaaaaac
     2941 tagaatattt tcctgtcaac ctagaggctg ttcttttgta gaacaaagtg tgtgatattt
     3001 catagtcata gcctttcatt gctggtcttg tcagtatgcc tttagtaaat accttttata
     3061 ttcaatgaca cgcttttctt aaaatatgaa ttttccctga ccacagagag atctgtctgg
     3121 ttcagtgctc agcactggag catgtgggcc acacctgctt cgccttccgt agcagggagg
     3181 ccgactgccc ttaccaagca ccaggtcaca cattgttagt ctcactttaa tggatggtgt
     3241 tccagataga gcagtgatgg taggaaatgg tgagaccaca acaatgctga tatacatagc
     3301 atacacacac atacactctc tctctctctc tctctctctc tctctctctc tctctctctc
     3361 tctctctctc acacacacac acacacacac acacacacac acacacacac acacacacac
     3421 gactaagggt ttttctgctg cttttggagg actgtaacat tctataacaa tttatttctt
     3481 tgttttagtg aacaagattt tgtacctgct ctatataccc cttttaatgt ttttgtaaca
     3541 acttaaattt aaaatgcaac attttggcat ttgctcagta gtgaatcact ttaaagcaga
     3601 tttttgtggg aaaaaaactt gtatatgtaa aaccttctat gttcacagtg gcattagcct
     3661 aggcacattt ttgttggtct ctccaagttc catagataaa ctagaatttg attttaaatg
     3721 ctaatttatg tcttagtttt tactgtttgg aagaagttta actaagtgtt actgatgaca
     3781 aggattcaac ctcaagtaaa gggcaaccat cttttaaaag caatttagct tgttatattg
     3841 taggtgcata gatctggtga ctgtagagat gggtaggagt tatactcaga actcactgat
     3901 ggacgtcaag gtactgttag gtaggattag gaagcctttg caatggagga gtcatgagta
     3961 cattaatctc ttcagcctca ccaacacaaa catgtactct tagcactgtt gcatggttgg
     4021 ctggctggtc cttaccaagc atacttggaa ggcccacatc tgtagctaga aagcgtgctg
     4081 gtctgctgcc tagagacaga tctgagaact gttttcatct ctgtcaaatg ttatctcctt
     4141 ttctagtaag tttttgtgag atttcaaatt attaaaatta cttcttaagg agtagctact
     4201 acctcatcct ccccaactga ctctttcagt ccccatcaaa acctgctcta actgctattc
     4261 cagttaacac tctatggctt gcttgtttaa taacatcatg cacttgtgct caacccaagt
     4321 atcagaaacg cgactcgcgg ctttgagagg tgattgtgat aggtctgctt ctcatctgca
     4381 gatacaatgc agcaactcca aagtattaag atcacactaa gctgaagatg cacctttgcc
     4441 ctggttagca acgcaaaacc gtatcgtcat acatgccaag gccttagcgt gtagatgtct
     4501 gtacaccggc acagcgaatg agctcactgc taatggctga gttgcttatt ttcatgaaca
     4561 aagattagca agaaactgtt aaaccatctt tttaaaaact gttctagttt gtcatatttt
     4621 aggcatgaag aactagcttg gcttactgaa gaaataaaag atttaaagag aacc
//
LOCUS       NM_001436834            3639 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 3, mRNA.
ACCESSION   NM_001436834 XM_063287766
VERSION     NM_001436834.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287766.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20647.1,
                                           SRR26360194.2074544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1623           JAXUCZ010000005.1  152852539-152852659 c
            1624-1665           JAXUCZ010000005.1  152852153-152852194 c
            1666-1791           JAXUCZ010000005.1  152850411-152850536 c
            1792-2253           JAXUCZ010000005.1  152847583-152848044 c
            2254-2449           JAXUCZ010000005.1  152846792-152846987 c
            2450-2659           JAXUCZ010000005.1  152844978-152845187 c
            2660-3639           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3639
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2767
                     /gene="Srrm1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 3"
                     /protein_id="NP_001423763.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSEDERPKRSHVKNGEVG
                     RRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSRRRRSPSPPPARRRRSPSP
                     APPPPPPPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA
                     SPPPPPKRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREA
                     RSPQPNKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKK
                     IKKAASPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAK
                     SPTPSPSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPA
                     AVSAAATPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    1157..>2176
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1157..>2176
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1868..>2659
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1868..>2659
                     /gene="Srrm1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1623
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1665
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1791
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2253
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2449
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2659
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..3639
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgaagatgag cggcccaaga gatcccatgt gaagaatggt gaggtaggca ggcggcggag
     1561 acattctcct tctcggagtg cctctccatc acctcgaaag cgccaaaaag agacttcccc
     1621 tcggatgcag atgggaaagc gatggcagtc gccagtgact aaaagtagaa ggaggagaag
     1681 tccttcccca cctcctgcca gaagacgacg atctccttct ccagcccctc ctccccctcc
     1741 tcccccacct cctcggcggc gcagatctcc caccccacca ccacgacgaa ggaccccttc
     1801 tcctccccca cgccgccgct caccgtctcc aagaagatac tctcctccca tccagaggag
     1861 atactctcct tccccacctc caaagaggag aactgcctcg cccccacccc cacccaagcg
     1921 aagggcatcg ccatctcctc caccaaagcg ccgggtttcc cactctccac ctcctaaaca
     1981 aagaagcccc ccagtcacca agagacgctc accctcctta tcttcaaagc ataggaaagg
     2041 gtcttcccca ggccgctcca ctcgggaggc ccggtcacca caaccaaaca aaaggcactc
     2101 gccctcacca cgacctcggg cgcctcagac ctcaagccct ccccctgttc gaagaggagc
     2161 ttcagcgtct ccccaaggaa ggcagtcccc gtctccgagt actaggccta ttaggagagt
     2221 ctccaggact ccggaaccca aaaagataaa aaaggctgcc tcaccaagcc ctcagtccgt
     2281 aagaagggtt tcatcttccc gctctgtctc tggatctcct gagccaacag ctaaaaagcc
     2341 tccagcaccc ccctctcctg tgcagtctca gtcaccctcc acaaactggt cacctgcagc
     2401 accagccaag aaggctaaaa gcccaacacc aagcccgtcc cctgccagga attctgatca
     2461 agaaggaggt ggaaagaaga agaagaagaa gaaggacaag aaacataaga aggataagaa
     2521 acacaagaag cacaaaaaac acaagaagga gaaggctgtg gccgtagcca ccccagctcc
     2581 tgctgcccct gcagctgtct ctgctgccgc cactccatca gcccaggaag agcctgcggc
     2641 agcaccagag cccaggaagg agactgagag tgaagctgaa gatgacaacc ttgatgactt
     2701 agagaggcac cttcgggaga aggcccttcg atccatgcgg aaggcccaag tgtccccaca
     2761 gtcctaggcg gacatgtttg ttacgttgta aattttattt ggtttgtact caattcaatt
     2821 tcaaaattgc taaaatgtgt ttgagcttta gactataaca tttgttgtaa taattgctag
     2881 gttgaagttc accatgttaa aaaagggggg catggattta cattacaaag gtgtccacgg
     2941 tgtattagtg acaattcttc cattgacatt tagagtgaaa tattttaagc caaaaaaaaa
     3001 tctctttttt aaaaaagggg gtttgaatat tgttggcatt tttgtggttc ctttaaatgc
     3061 cctcgcctct cccaaaaggt tggggtcttt tctttttctc cctattctct tgaatcttag
     3121 cacccatgta aattatgctt ccaaccttgt ataggtttgt aagcttgccc agaagtgaga
     3181 gcactgttga agtaccacag aggtttgggc gagtgagtgt tgactctgtt gcccatggag
     3241 tctgctgtcc tggcagcatc ccagctctag agcgccgcac tcctgagcta cagggctgcc
     3301 ccatggaaca gttcctaaac tgactaggaa ctctgggttt tctccttccg gttgtgttgt
     3361 tttgtttcct tctccccttt tcttcctctt ttgtaaaggc gattcactag acccaggaag
     3421 gacccttcag ttacataaat ttgttttatg aaacatggtg gctcccattc atggtttccc
     3481 ttactcttcc aattggtaca cacaactgag gagctcctgt atttggccgg ctggaagggc
     3541 ctggacagtg tcttgatttc acttgtttta ttttatttta ttttttaact aaagctatat
     3601 aaagcttgtg gattaaacag aataaatttc taaatttaa
//
LOCUS       NM_001436785            3487 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 12, mRNA.
ACCESSION   NM_001436785 XM_063275200
VERSION     NM_001436785.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275200.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.154926.1,
                                           SRR26360181.2537162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000016.1  19463631-19463936
            307-408             JAXUCZ010000016.1  19508790-19508891
            409-666             JAXUCZ010000016.1  19523772-19524029
            667-799             JAXUCZ010000016.1  19543122-19543254
            800-931             JAXUCZ010000016.1  19543358-19543489
            932-1021            JAXUCZ010000016.1  19543675-19543764
            1022-1153           JAXUCZ010000016.1  19544907-19545038
            1154-1318           JAXUCZ010000016.1  19545145-19545309
            1319-1598           JAXUCZ010000016.1  19546706-19546985
            1599-1900           JAXUCZ010000016.1  19548553-19548854
            1901-1975           JAXUCZ010000016.1  19549511-19549585
            1976-2168           JAXUCZ010000016.1  19549883-19550075
            2169-3487           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3487
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..306
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            307..408
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            409..666
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2299
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 4 is encoded by transcript variant 12; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 4"
                     /protein_id="NP_001423714.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAFR
                     SGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSE
                     RVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQ
                     SATWK"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    806..925
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1655..1756
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1655..1756
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            667..799
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            800..931
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1021
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1153
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1318
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1598
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1900
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1975
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2168
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..3487
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaagcggg caatttcagt gtgagaagga gcggtgagac cgagcggcgg ctccgagcgc
       61 gccgcggcag ctccttccgc ccggggtcag cgccccggcg cgcgcacgcg caccctcgct
      121 gcctgagcgc gccccgcgcc gcccgcgcag tcggtccgtc ggtcgtccgt cgtcctgtcg
      181 ccgccgccgc ctcaggcgcc acccgcggga gccgtcgccg tgggacgaga ccggaccgga
      241 cccgagcgct ctgcctgagg ctggcccggg gcccagctgc ggatcgcgcg gagctgagca
      301 acttcggttg gccagcacat tgagccagca catccacata agttgccttt tgacagagct
      361 gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa tgagtgaaga
      421 agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg aggatgatgt
      481 ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg atggagacag
      541 cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga caacagaggc
      601 catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca tgcgtacctc
      661 acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg tgctctctga
      721 cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct tgaaagacac
      781 cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga tcaagcagct
      841 gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc tgcgacagag
      901 tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga gcactgtgac
      961 cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc catcactcca
     1021 gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc gaggtgggca
     1081 gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc caccacttgt
     1141 caggggagcc cagattcaca acatcagaca gcattcctcc acggggccac cacccctcct
     1201 cctggccccc cgtgcctcag tgcccagcat gcagattcag ggacagagga tcatccagca
     1261 gggactcatc cgggtcgcca atgtccccaa caccagtctg ctcgtcaata tccctcagcc
     1321 tacggcagcc tcactgaagg ggacaacagt tggctctgct caggcaaact ccactcccag
     1381 cagtgtggct tctgtggttg cctctgctga gtccccagct agccggcagg ctgctgccaa
     1441 gctagcgctg cgcaagcagt tggagaagac actgctggag atccccccac ccaagccccc
     1501 tgctccggag atgaacttct tgcccagtgc tgccaacaat gaattcatct atctggtcgg
     1561 cttggaggaa gtggtgcaga acctgctgga gacgcaagcg ggcaggattt ctgccacctc
     1621 agctgctgcc gtgttatccc gggagcctta catgtgtgtg cagtgtaaga cagacttcac
     1681 atgccgctgg cgagagaagg gtggagctgt catgtgtgag aactgcatga catccaacca
     1741 aaagaaggca ctaaaagtgg agcacaccag tcgcctgaag gccgccttcg tgaaggcgct
     1801 acaacaagag caggagatgg agcagcgact gctgcagcag ggcgtaggca ccgccagcat
     1861 caaggctgag accgcagctc cacatccctc gctgaagcag gtcataaagc cccgacgtaa
     1921 gttggcgttc cgctcaggag aggcccgtga ctggaataac gggtccgtac tacagacttc
     1981 cagccagctg tcccggggtt cagccacaac acctcgtggt gttctgcaca ctttcagcca
     2041 gtcacccaaa ctgcagaacg cagcctcagc tacggccctg gtaagcagga ctggcagaca
     2101 ttccgagaga gtcgtgggca ccagcaaggg caccgcctcc aactggaaaa agacacctct
     2161 gagcacaggt gggacgcttg ccttcgtcag cccaagcttg gcagtgcaca agagctcctc
     2221 ggccgtggac cgacagcgag agtacctcct ggacatgatt cctccacgct ccatccccca
     2281 gtcagccaca tggaaatagt gggagccggc ccagccgagg acaggccctc tgctctcccg
     2341 aggcccttgg tctaggacac gcagactacc ctcctagcaa gttgcctgag acagctcagg
     2401 ccttggctct tgccttgctg tggccaggag agtaccacca tggtgcccag gatcagaacc
     2461 agggaccttc cctatgggcc ttctccttcc tttttgcctt tagtttgccc gacaccagca
     2521 gaaactcgga ccttggggcc agctctgcct ggccagcgtg ggtgggagct caccctggac
     2581 actgtgacac acccgggcca gactggcacc gggggctccc gaagttgagc cgggatttcg
     2641 ttttcttttg gcttttccca tcttagctcc ccagtctctg cctcttcatg gccatctata
     2701 ggttgaagtt tgggttttat tgggtttttt gtttttgttt tttttataat cacctcataa
     2761 tgatgatgga attaaagtga actgcataga cccagggtca tggttgtgca cagtgcagtc
     2821 tggcaggctc taccccagag gatgctcaga gtggcagcag cagagatggc aggtgccacc
     2881 ctggctctgg tcgtgtttgt tgctgctcac tgcagtccct ggcttccaca cttagcagaa
     2941 tgaaccgcag cccagatctg tctgacatcc agaggctcca gagggatgct ggggtccgcc
     3001 atgctggagt cagagctgac tgctggctgg gaggctgctg ggttactttt cgtggtttat
     3061 tttattaaaa atttctatcc tttttctctt cattttgatg gacacaatct caagatgccc
     3121 atgcctgcca agaggcatcc aagtagggcc cagccagaac ccttaggtct ggagtcagca
     3181 gggcttactc cctcttagcc acagggatgt ctgaaagggc tgagtctact tttgttctgt
     3241 tttgtttcct tctccctcca ctcttaacaa tgggttccat ggtgaaaggc agaagcagct
     3301 ctgtgtccag cacgcacggt gcggccttct gctcatgtga ttggtcgccg tcgtttcccc
     3361 atccagccct ggtttccctt gacacaatac agttagggac tttaatttaa acccttgttc
     3421 tgcagaccat cgccctctgc agacatgccc ctgcctcctc ctaataaagg ctcatttaac
     3481 tccgtga
//
LOCUS       NM_001107966            4397 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus lysine demethylase 4A (Kdm4a), transcript variant
            3, mRNA.
ACCESSION   NM_001107966 XM_001072204 XM_233441
VERSION     NM_001107966.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4397)
  AUTHORS   Li,L., Ding,Z., Ma,F., Zhang,K., Lu,D., Wang,H. and Yang,K.
  TITLE     Spinal nerve transection-induced upregulation of KDM4A in the
            dorsal root ganglia contributes to the development and maintenance
            of neuropathic pain via promoting CCL2 expression in rats
  JOURNAL   Eur J Neurosci 60 (6), 5169-5188 (2024)
   PUBMED   39136140
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of KDM4A in
            the dorsal root ganglia contributes to the development and
            maintenance of neuropathic pain via promoting CCL2 expression in
            rats.
REFERENCE   2  (bases 1 to 4397)
  AUTHORS   Li,W., Zhang,Y., Lv,J., Zhang,Y., Bai,J., Zhen,L. and He,X.
  TITLE     MicroRNA-137-mediated lysine demethylase 4A regulates the recovery
            of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis
  JOURNAL   Int J Neurosci 133 (1), 37-50 (2023)
   PUBMED   33499717
  REMARK    GeneRIF: MicroRNA-137-mediated lysine demethylase 4A regulates the
            recovery of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis.
REFERENCE   3  (bases 1 to 4397)
  AUTHORS   Liu,Y., Zhao,L., Zhang,J., Lv,L., Han,K., Huang,C. and Xu,Z.
  TITLE     Histone Demethylase KDM4A Inhibition Represses Neuroinflammation
            and Improves Functional Recovery in Ischemic Stroke
  JOURNAL   Curr Pharm Des 27 (21), 2528-2536 (2021)
   PUBMED   33402077
  REMARK    GeneRIF: Histone Demethylase KDM4A Inhibition Represses
            Neuroinflammation and Improves Functional Recovery in Ischemic
            Stroke.
REFERENCE   4  (bases 1 to 4397)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   5  (bases 1 to 4397)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 4397)
  AUTHORS   Sohi,G., Marchand,K., Revesz,A., Arany,E. and Hardy,D.B.
  TITLE     Maternal protein restriction elevates cholesterol in adult rat
            offspring due to repressive changes in histone modifications at the
            cholesterol 7alpha-hydroxylase promoter
  JOURNAL   Mol Endocrinol 25 (5), 785-798 (2011)
   PUBMED   21372147
REFERENCE   7  (bases 1 to 4397)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 4397)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 4397)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
REFERENCE   10 (bases 1 to 4397)
  AUTHORS   Zhang,D., Yoon,H.G. and Wong,J.
  TITLE     JMJD2A is a novel N-CoR-interacting protein and is involved in
            repression of the human transcription factor achaete scute-like
            homologue 2 (ASCL2/Hash2)
  JOURNAL   Mol Cell Biol 25 (15), 6404-6414 (2005)
   PUBMED   16024779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001107966.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760386, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000005.1  137004797-137004888 c
            93-268              JAXUCZ010000005.1  137000421-137000596 c
            269-383             JAXUCZ010000005.1  136994699-136994813 c
            384-577             JAXUCZ010000005.1  136993217-136993410 c
            578-627             JAXUCZ010000005.1  136991038-136991087 c
            628-731             JAXUCZ010000005.1  136989469-136989572 c
            732-869             JAXUCZ010000005.1  136988994-136989131 c
            870-1114            JAXUCZ010000005.1  136986918-136987162 c
            1115-1314           JAXUCZ010000005.1  136986178-136986377 c
            1315-1682           JAXUCZ010000005.1  136983358-136983725 c
            1683-1803           JAXUCZ010000005.1  136975431-136975551 c
            1804-1985           JAXUCZ010000005.1  136971303-136971484 c
            1986-2190           JAXUCZ010000005.1  136969629-136969833 c
            2191-2267           JAXUCZ010000005.1  136969129-136969205 c
            2268-2323           JAXUCZ010000005.1  136968639-136968694 c
            2324-2432           JAXUCZ010000005.1  136966908-136967016 c
            2433-2618           JAXUCZ010000005.1  136966445-136966630 c
            2619-2789           JAXUCZ010000005.1  136963305-136963475 c
            2790-2909           JAXUCZ010000005.1  136960072-136960191 c
            2910-3002           JAXUCZ010000005.1  136959687-136959779 c
            3003-4397           JAXUCZ010000005.1  136958178-136959572 c
FEATURES             Location/Qualifiers
     source          1..4397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4397
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="lysine demethylase 4A"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
     exon            1..92
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    75..77
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="upstream in-frame stop codon"
     exon            93..268
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3143
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /EC_number="1.14.11.-"
                     /note="isoform b is encoded by transcript variant 3;
                     lysine-specific demethylase 4A; jumonji domain containing
                     2A; lysine (K)-specific demethylase 4A"
                     /codon_start=1
                     /product="lysine-specific demethylase 4A isoform b"
                     /protein_id="NP_001101436.1"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
                     /translation="MTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGAD
                     VNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMD
                     LYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLK
                     KYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
                     KDMVKISMDVFVRRFQPERYKLWKAGKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEE
                     CPEEDSEAAEQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYE
                     MTECQATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAA
                     ALDLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETTESVSCQGQEKTVLT
                     VHSYSRGDGKAAPGEPSVKRQRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLS
                     KLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNE
                     LMAQQAPHCAVCMIFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCS
                     TDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDC
                     CLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFC
                     KKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLER
                     AKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQ
                     DCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLD
                     EELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME"
     misc_feature    477..827
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    477..827
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    1947..2246
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    1947..2246
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    order(1947..1949,2148..2162,2172..2174,2229..2231)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    order(1947..1949,2148..2162,2172..2174,2229..2231)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    2271..2600
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    2271..2600
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    order(2433..2435,2475..2489,2505..2507,2583..2585)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    order(2433..2435,2475..2489,2505..2507,2583..2585)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    2643..2807
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    2643..2807
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    order(2739..2744,2748..2759,2763..2765)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    order(2739..2744,2748..2759,2763..2765)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    2814..2981
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    2814..2981
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    order(2847..2855,2865..2867)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     misc_feature    order(2847..2855,2865..2867)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     exon            269..383
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            384..577
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            578..627
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            628..731
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            732..869
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1114
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1314
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1682
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1803
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1985
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2190
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2267
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2323
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2432
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2618
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2789
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2909
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3002
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..4397
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttgtctt tcgccctcaa gaaagacagt gggatcggcg agtggcgaca gcaggaatcg
       61 agcctgagcc ctgctagggc tttaggctcc aggttgttcc tcccaaagaa tggaagcctc
      121 gaacctccta tgatgacatc gacgatctgg tcatccctgc acccatccag cagctggtga
      181 ctggccagtc cggcctcttc actcagtaca atatacagaa gaaagccatg actgttcgtg
      241 agttccgcaa gatcgccaat agtgacaagt actgtactcc acggtatagt gaatttgaag
      301 aacttgagcg taaatactgg aaaaacctca cattcaatcc tcccatctat ggagcagatg
      361 tgaatggtac tctctatgaa cagcacgttg atgagtggaa catcggccgg ctgaagacca
      421 tcctggacct ggtggagaag gagagtggga tcaccatcga gggcgtgaac accccctacc
      481 tgtactttgg catgtggaag acgtcctttg cctggcacac ggaagacatg gatctgtaca
      541 gcatcaacta cctgcacttt ggagagccaa agtcttggta ctctgttcca cctgagcatg
      601 ggaaacgcct ggagcggctc gccaaaggct ttttcccagg aagtgctcaa agctgtgagg
      661 cttttctccg ccacaagatg accctgatct ccccattaat gctgaagaag tatggcattc
      721 cctttgacaa ggtgacccaa gaagccgggg agtttatgat cacttttcca tatgggtacc
      781 atgctggttt caaccatggc ttcaactgtg cagagtctac caattttgct acccgtcggt
      841 ggattgaata tggcaagcag gctgtactgt gttcctgcag aaaagatatg gtgaagatct
      901 ctatggacgt gtttgtcagg aggttccagc cggaacgcta caaactttgg aaagctggga
      961 aagacagcac tgttattgac cacactctgc ccacaccgga agcagctgag tttctgaagg
     1021 acagtggact aaccccaaga gctgggaatg aggagtgccc agaggaggac tcggaagcgg
     1081 cggagcaggg agaggagggg gatgtgaaga gaagcctggc taagcaccga atagggacaa
     1141 agagacaccg agtctgtctg gaaataccac aggaggtcag tcagagcgag ctcttcccca
     1201 aggaagagct gagttctgga cagtatgaga tgacagagtg ccaggccacc ctcgccccag
     1261 tgaggcccac ccacagctcc gtgcggcaag ttgaggacag ccttcccttc ccagattact
     1321 ccgaccccac tgaggtcaaa ttcgaagagc tgaagaacgt caaactagaa gaggaggatg
     1381 aggatgagga gccggaagca gctgcactgg acctttctgt gaatcccgag tctgtagaag
     1441 gacgcctcgt cttctcgggc tccaaaaaga aagcctcctc cagcctaggc tccagttcct
     1501 ctcaggattc agtttcttca gattccgaaa ccaccgagtc tgtctcttgc cagggccaag
     1561 agaaaacagt tctcacggtg cacagctact ccagaggaga tggcaaggct gccccaggcg
     1621 agccgagtgt gaagaggcag cgcagcgccc cccgcagcat cagcgagcag gagctggcag
     1681 aggttgcaga tgagtacatg ctctccctgg aggagaataa gaagaccaag ggtcgccgcc
     1741 agcccttgag caagctccca cgccatcacc cgctggtgtt gcaggagtgc ggcagcgatg
     1801 acgagacttc tgaacagctg acacccgagg aagaggctga ggagaccgag gcttgggcta
     1861 agcctctgag ccagctgtgg cagaaccgac ctccaaactt tgaggctgaa aaggaattca
     1921 atgagctcat ggcccagcag gcccctcact gtgctgtgtg tatgatcttc cagacctacc
     1981 atcaggtgga atttggaggc ttcagtcaga gctgtgggaa tgcttcagaa ccagctgccc
     2041 aacctcagag gactaagcca ttgatccccg aaatgtgctt taccacaact ggctgcagca
     2101 cagacatcaa tctgtccacc ccttacctag aggaggatgg caccagcatg ctggtgtctt
     2161 gtaagaagtg cagtgtccgg gtccacgcca gttgctatgg cgtcccccct gcaaaggctt
     2221 ctgaagaatg gatgtgctct cgatgttcag ccaatgccct ggaggaagac tgctgtttat
     2281 gctcactgcg tggaggggcc ctgcagagag caaacgacga cagatgggtt catgtttcat
     2341 gtgctgtggc aattctagaa gcaaggtttg tcaacattgc tgaaagaagt ccagtggatg
     2401 tgagcaaaat ccctctgccc cgcttcaaac tgaagtgtgt cttttgtaag aagcgaagaa
     2461 aacggaatgc tggctgttgt gtgcagtgct ctcacggccg ctgccccact gccttccatg
     2521 tgagctgtgc ccaggctgcc ggggtgatga tgcaacccga tgactggcct tttgttgtct
     2581 tcatcacgtg cttccgccac aagattccca atttggagcg agctaaggga gccttgctga
     2641 gcatcacggc cggccagaag gtcatcagca agcacaagaa cggccgcttc taccagtgcg
     2701 aggtggtcag actcaccacc gaaaccttct acgaagtcaa ctttgatgac ggctccttca
     2761 gcgacaacct ttatcctgag gacatagtga gtcaggactg tctccaactg gggcctcctg
     2821 ctgaaggcga agtggttcaa gtcagatgga cagatggtca agtctatggg gctaagtttg
     2881 tggcctccca ccccatccag atgtaccagg tggagttcga ggatggctcg cagctggtgg
     2941 ttaagagaga tgatgtatac acactggatg aagagcttcc caagagagtc aagtctagac
     3001 tgtcagtagc ttcagacatg cggttcaatg agattttcac agagaaggaa gtaaagcaag
     3061 aaaagaaaag gcaacgggtc atcaactcaa ggtaccggga ggattacatc gagccagcac
     3121 tgtatcgggc catcatggag tagacgtttc ccgggtctga gaggtcccag ccatcaaggc
     3181 gagaacactc tcgggttcca cagcacagca gacacttgga actcagaagt cttagaaaga
     3241 gaagctgtac aaagaaaagg aatgacatgt ctgacccatc accttctcac tcctccttca
     3301 atgaattctg ccgtgaaaag acaagccggg cgcttggcag cagctgacgc tgacactggg
     3361 atgctgtgac tccatcagcg cccagtccaa accggtcagc tgttcctgct gggcggattg
     3421 ttgtttctta gcctaggact agcttcctac cacccacctg caccagcaag gcagagaggt
     3481 gctggtgctc aacccaatcc ccttttgtat ttatgtatga gtgtgtgagt gcacgcatgt
     3541 acaggtgtgt acctgtgtga gagcgctcga gtgtgcacct gtgtgcttga gaatgtgtgg
     3601 gtgtgcaagc acgtgtgtgt gtgtgtgcgc gagtgcctgt gtgcatgagt gcatgagtgt
     3661 gtgtgtggga gtgtgcttga tctggactag cttcagccag cccctgggct tcactttctc
     3721 ctttgcctct gcagggcaaa caaaatgtga aattctgccc tcagctaagc tgagtaaggg
     3781 ccctggggga tggctagagg ttggttgcca tctgtccctt cctggaccga tttcaagaga
     3841 gtgctggcaa agctgcagta ttgggatgct aaggagctga ctgccacctc tgtccaccct
     3901 tggagtagaa ctcagaggtt ctgtactatg agcccacaaa cttcaggcac ggaagcccct
     3961 gtggcagtgt tagagggtgt gggtggggcc taccttgaag ggagaatttt aatgatggaa
     4021 acaggcagag cctggtgggt aatttttgtg caggggaaaa aattgcagtt atgcaggggc
     4081 tatctgtggg ttaggatgaa ctggggccac tggaggccaa gggcaggtgt agccacgccc
     4141 ttggtcaggg gtggggtggg gctgattgag ggtggggggg tgggactgga gggcaacatt
     4201 gaaggggtta aacaggtttt tgctcctctt gaatttgttt gcctgggccc aatattggag
     4261 ggcttcatac cttgctctgt atacaggagt cagatttata atacttcccc ttttttgtta
     4321 cgtatgaact ctataaacca aattattttg aaaactggtg cattaccttg tccttagcaa
     4381 taaaatgtat tgagcag
//
LOCUS       NM_001436836            3600 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 6, mRNA.
ACCESSION   NM_001436836 XM_039110050
VERSION     NM_001436836.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3600)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3600)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3600)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3600)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3600)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3600)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039110050.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.8150.1,
                                           SRR26643295.23231.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1623           JAXUCZ010000005.1  152852539-152852659 c
            1624-1752           JAXUCZ010000005.1  152850411-152850539 c
            1753-2214           JAXUCZ010000005.1  152847583-152848044 c
            2215-2410           JAXUCZ010000005.1  152846792-152846987 c
            2411-2620           JAXUCZ010000005.1  152844978-152845187 c
            2621-3600           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3600
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2728
                     /gene="Srrm1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 6"
                     /protein_id="NP_001423765.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSEDERPKRSHVKNGEVG
                     RRRRHSPSRSASPSPRKRQKETSPRSRRRRSPSPPPARRRRSPSPAPPPPPPPPPRRR
                     RSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPS
                     PPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQPNKRHSPSP
                     RPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVR
                     RVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSD
                     QEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEE
                     PAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1154..2200
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1154..2200
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1829..2416
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1829..2416
                     /gene="Srrm1"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1623
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1752
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..2214
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2410
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2620
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..3600
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgaagatgag cggcccaaga gatcccatgt gaagaatggt gaggtaggca ggcggcggag
     1561 acattctcct tctcggagtg cctctccatc acctcgaaag cgccaaaaag agacttcccc
     1621 tcgtagtaga aggaggagaa gtccttcccc acctcctgcc agaagacgac gatctccttc
     1681 tccagcccct cctccccctc ctcccccacc tcctcggcgg cgcagatctc ccaccccacc
     1741 accacgacga aggacccctt ctcctccccc acgccgccgc tcaccgtctc caagaagata
     1801 ctctcctccc atccagagga gatactctcc ttccccacct ccaaagagga gaactgcctc
     1861 gcccccaccc ccacccaagc gaagggcatc gccatctcct ccaccaaagc gccgggtttc
     1921 ccactctcca cctcctaaac aaagaagccc cccagtcacc aagagacgct caccctcctt
     1981 atcttcaaag cataggaaag ggtcttcccc aggccgctcc actcgggagg cccggtcacc
     2041 acaaccaaac aaaaggcact cgccctcacc acgacctcgg gcgcctcaga cctcaagccc
     2101 tccccctgtt cgaagaggag cttcagcgtc tccccaagga aggcagtccc cgtctccgag
     2161 tactaggcct attaggagag tctccaggac tccggaaccc aaaaagataa aaaaggctgc
     2221 ctcaccaagc cctcagtccg taagaagggt ttcatcttcc cgctctgtct ctggatctcc
     2281 tgagccaaca gctaaaaagc ctccagcacc cccctctcct gtgcagtctc agtcaccctc
     2341 cacaaactgg tcacctgcag caccagccaa gaaggctaaa agcccaacac caagcccgtc
     2401 ccctgccagg aattctgatc aagaaggagg tggaaagaag aagaagaaga agaaggacaa
     2461 gaaacataag aaggataaga aacacaagaa gcacaaaaaa cacaagaagg agaaggctgt
     2521 ggccgtagcc accccagctc ctgctgcccc tgcagctgtc tctgctgccg ccactccatc
     2581 agcccaggaa gagcctgcgg cagcaccaga gcccaggaag gagactgaga gtgaagctga
     2641 agatgacaac cttgatgact tagagaggca ccttcgggag aaggcccttc gatccatgcg
     2701 gaaggcccaa gtgtccccac agtcctaggc ggacatgttt gttacgttgt aaattttatt
     2761 tggtttgtac tcaattcaat ttcaaaattg ctaaaatgtg tttgagcttt agactataac
     2821 atttgttgta ataattgcta ggttgaagtt caccatgtta aaaaaggggg gcatggattt
     2881 acattacaaa ggtgtccacg gtgtattagt gacaattctt ccattgacat ttagagtgaa
     2941 atattttaag ccaaaaaaaa atctcttttt taaaaaaggg ggtttgaata ttgttggcat
     3001 ttttgtggtt cctttaaatg ccctcgcctc tcccaaaagg ttggggtctt ttctttttct
     3061 ccctattctc ttgaatctta gcacccatgt aaattatgct tccaaccttg tataggtttg
     3121 taagcttgcc cagaagtgag agcactgttg aagtaccaca gaggtttggg cgagtgagtg
     3181 ttgactctgt tgcccatgga gtctgctgtc ctggcagcat cccagctcta gagcgccgca
     3241 ctcctgagct acagggctgc cccatggaac agttcctaaa ctgactagga actctgggtt
     3301 ttctccttcc ggttgtgttg ttttgtttcc ttctcccctt ttcttcctct tttgtaaagg
     3361 cgattcacta gacccaggaa ggacccttca gttacataaa tttgttttat gaaacatggt
     3421 ggctcccatt catggtttcc cttactcttc caattggtac acacaactga ggagctcctg
     3481 tatttggccg gctggaaggg cctggacagt gtcttgattt cacttgtttt attttatttt
     3541 attttttaac taaagctata taaagcttgt ggattaaaca gaataaattt ctaaatttaa
//
LOCUS       NM_001436705            3088 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus poly(A) binding protein, cytoplasmic 4 (Pabpc4),
            transcript variant 1, mRNA.
ACCESSION   NM_001436705 XM_006238800
VERSION     NM_001436705.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   Kini,H.K., Kong,J. and Liebhaber,S.A.
  TITLE     Cytoplasmic poly(A) binding protein C4 serves a critical role in
            erythroid differentiation
  JOURNAL   Mol Cell Biol 34 (7), 1300-1309 (2014)
   PUBMED   24469397
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3088)
  AUTHORS   Burgess,H.M., Richardson,W.A., Anderson,R.C., Salaun,C.,
            Graham,S.V. and Gray,N.K.
  TITLE     Nuclear relocalisation of cytoplasmic poly(A)-binding proteins
            PABP1 and PABP4 in response to UV irradiation reveals
            mRNA-dependent export of metazoan PABPs
  JOURNAL   J Cell Sci 124 (Pt 19), 3344-3355 (2011)
   PUBMED   21940797
REFERENCE   5  (bases 1 to 3088)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   6  (bases 1 to 3088)
  AUTHORS   Yang,H., Duckett,C.S. and Lindsten,T.
  TITLE     iPABP, an inducible poly(A)-binding protein detected in activated
            human T cells
  JOURNAL   Mol Cell Biol 15 (12), 6770-6776 (1995)
   PUBMED   8524242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006238800.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19995.1,
                                           SRR26643298.28794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              JAXUCZ010000005.1  140848276-140849352
            1078-1271           JAXUCZ010000005.1  140852530-140852723
            1272-1387           JAXUCZ010000005.1  140854672-140854787
            1388-1527           JAXUCZ010000005.1  140855891-140856030
            1528-1622           JAXUCZ010000005.1  140856353-140856447
            1623-1760           JAXUCZ010000005.1  140857201-140857338
            1761-1856           JAXUCZ010000005.1  140858172-140858267
            1857-2129           JAXUCZ010000005.1  140859462-140859734
            2130-2217           JAXUCZ010000005.1  140859968-140860055
            2218-2337           JAXUCZ010000005.1  140860181-140860300
            2338-2465           JAXUCZ010000005.1  140860911-140861038
            2466-2559           JAXUCZ010000005.1  140862618-140862711
            2560-2690           JAXUCZ010000005.1  140862797-140862927
            2691-2787           JAXUCZ010000005.1  140863198-140863294
            2788-3088           JAXUCZ010000005.1  140863789-140864089
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3088
                     /gene="Pabpc4"
                     /note="poly(A) binding protein, cytoplasmic 4"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
     exon            1..1077
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    834..836
                     /gene="Pabpc4"
                     /note="upstream in-frame stop codon"
     CDS             885..2780
                     /gene="Pabpc4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     poly(A) binding protein, cytoplasmic 4 (inducible form);
                     polyadenylate-binding protein 4"
                     /codon_start=1
                     /product="polyadenylate-binding protein 4 isoform 1"
                     /protein_id="NP_001423634.1"
                     /db_xref="GeneID:298510"
                     /db_xref="RGD:1305015"
                     /translation="MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCR
                     DMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVF
                     IKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAANKAIEKMNG
                     MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDENLRELFSQFGKTL
                     SVKVMRDCSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKSIFVGRAQKKVERQAEL
                     KRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKG
                     FGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRAL
                     PANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMP
                     SALRQSGPRPALRHLAPTGNAPASRGLPTTAQRVGVPTAVPNLAPRATVAAAAPRAVA
                     PYKYASNVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLI
                     QTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVG
                     TVAAATS"
     misc_feature    915..2717
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    915..2717
                     /gene="Pabpc4"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            1078..1271
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1387
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1527
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1622
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1760
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1856
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2129
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2337
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2465
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2559
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2690
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2787
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..3088
                     /gene="Pabpc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgaccag cagcgcccgg ggcgggaggg tataaatgga gcggtggctg cttcagccgc
       61 ctctctccgc cccgggtcgc agtcgctagt gctgcgtttg ggctcagcaa gcctaaagca
      121 aaaaagagaa aaagcttaaa aaaaatttaa aaaagcctca aaaaacccta aaaaaaagaa
      181 aagaagaaaa gaagagaaaa aaaaagaaaa aggaaggaaa agaagaaaaa gaacgagacc
      241 gcgacttgtg ctgggagccc gcggggaagt gactttcaca gcttccggcc tgcctgtccg
      301 tcggcgtctg tctgtccgtc ccgtggtgag ccgtccccca ggcccggccc gcccccgcac
      361 gcctccgcgc cgcgtggcag ccccgcgccc cggctggccg caccacgtgt ccgcgctgcc
      421 cttcgccggc acccgcaaag atttggtttc ccccttcccg ggccgctgta attgtaaacc
      481 gccgggagcc cggggcctat atttatcgcg aaacgcgtgt ccccaaggcc gctgtgagcg
      541 cagcatctgg ctgcctctag aaaaaatttt tgccccctct gcaaggggat tccctacttc
      601 aatttttatc ttttaagctc caagccagga cagctggaga gtacaaactc caggagaggg
      661 ccatattgtt tttgagagcc ttttgtcttg gggcttttgc ggtccggtgt aagtcgtccc
      721 gcactccggt cccgcctcgg agcctccctg ctccagcctc tcccagcgtc gctggtgcca
      781 cctgtgcgct gcggcgcgtg ccacagctct tcggagcccc ttttgtcctg cagtaggccc
      841 tgcaagaagt cctggcgggg ctcggggtag tagggggtgg ggagatgaac gctgcggcca
      901 gcagctaccc catggcctcc ttatacgtgg gcgatctgca ctccgatgtc accgaagcca
      961 tgctgtatga aaagttcagc cctgcggggc ctgtgctgtc catccgggtc tgccgcgata
     1021 tgatcacccg ccgctctctg ggttatgcct acgtcaactt ccagcagcca gctgacgctg
     1081 agagggcctt ggacaccatg aactttgatg tgattaaggg gaagccaatc cggatcatgt
     1141 ggtctcagag ggacccctct ttgaggaagt ctggtgtggg aaatgtcttc atcaagaacc
     1201 tggacaagtc tatagacaac aaggcactgt atgacacttt ctctgccttc ggaaacatcc
     1261 tgtcctgtaa ggtggtctgt gatgagaacg gctctaaggg ttatgccttt gtccacttcg
     1321 agacccaaga ggctgccaac aaggccatcg agaagatgaa tggcatgctc ctcaatgacc
     1381 gcaaagtgtt cgtgggcaga ttcaagtctc gcaaagagcg ggaagccgag cttggagcca
     1441 aggccaagga attcaccaat gtttatatca aaaactttgg agaagaggtg gatgatgaga
     1501 atctgaggga gctattcagc cagtttggta agaccttaag tgtcaaggtg atgagagact
     1561 gcagtgggaa gtccaaaggc ttcggcttcg tgagctatga gaaacatgag gatgccaata
     1621 aggctgtgga agaaatgaat ggaaaagaaa tgagtgggaa atccatattt gtaggccgtg
     1681 ctcagaaaaa agtagaacgt caggcggagt taaaacggaa attcgaacag ctgaagcagg
     1741 agaggattag tcggtaccag ggagtgaatc tctacattaa gaacttggat gacaccattg
     1801 acgatgagaa gttaaggaaa gagttctcac cctttggatc aatcaccagt gcgaaggtga
     1861 tgctggaaga cgggagaagc aaagggtttg gctttgtctg tttctcctct cctgaagagg
     1921 caaccaaagc ggtcacggag atgaacggac gcattgtggg ctccaagcct ctgtacgtcg
     1981 ccctggccca gaggaaggag gagcggaagg ctcacctgac taaccagtat atgcagcgtg
     2041 tggcaggaat gagagcgctc cctgccaacg ccatcttaaa tcagttccag cctgcagctg
     2101 gtggctactt tgtgccggca gtgccacagg cccagggaag acctccatat tacacaccta
     2161 atcaattagc gcaaatgagg cctaatccac gctggcagca aggcgggaga cctcaaggct
     2221 tccaaggaat gccaagtgcc ctgcggcaat ctgggcctcg tccagctctt cggcatctgg
     2281 ctccaactgg taatgctccg gcctctcgtg gccttcctac taccgctcag agagtcggcg
     2341 tccctacggc tgtgccaaac cttgcacctc gtgctacagt cgctgctgct gctcccaggg
     2401 ctgtggctcc atacaagtat gcctccaatg tccgcagccc tcaccctgcc attcagccgc
     2461 tgcaggcccc ccagcctgca gtccatgtcc agggtcaaga acccctgact gcctccatgc
     2521 tggctgcagc tcctccccag gagcagaagc agatgctggg ggagcgtttg ttcccactta
     2581 tccaaacaat gcattcaaac ctggctggaa aaattacagg gatgctgcta gaaatcgaca
     2641 actctgagct gctccacatg ctggagtccc ccgagtccct ccgttccaag gtggatgaag
     2701 ctgtggcagt cctgcaggct catcatgcca agaaagaagc tgcccagaag gtgggcactg
     2761 ttgctgctgc tacctcttaa accagaagag tcaaaagcca aataacccct cacggcattc
     2821 agctgaggtc tgaagacttc ctagtttgtc tgtggacctc tttcaagaac caagttacaa
     2881 attcaacagg tcattttgta tcaaaaggtc aattatgaag cacctagaat ttttcaatta
     2941 taagaatata ttctctgggt tctgttgtgg cccagatgat ggtaactttt ttttctatta
     3001 tgagttctgt tttttttccc ctctcccaga aattggtttt gatgtaccca agacttaagt
     3061 ttctcaataa aggaaataaa atctccaa
//
LOCUS       NM_001436671            3433 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436671 XM_006252606
VERSION     NM_001436671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3433)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3433)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3433)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252606.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.58127.1,
                                           SRR26360172.421545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000016.1  6453402-6453566
            166-195             JAXUCZ010000016.1  6453662-6453691
            196-250             JAXUCZ010000016.1  6453812-6453866
            251-383             JAXUCZ010000016.1  6454871-6455003
            384-503             JAXUCZ010000016.1  6455366-6455485
            504-565             JAXUCZ010000016.1  6455976-6456037
            566-708             JAXUCZ010000016.1  6456213-6456355
            709-787             JAXUCZ010000016.1  6456604-6456682
            788-911             JAXUCZ010000016.1  6457065-6457188
            912-1059            JAXUCZ010000016.1  6457443-6457590
            1060-1244           JAXUCZ010000016.1  6458022-6458206
            1245-1372           JAXUCZ010000016.1  6458575-6458702
            1373-1851           JAXUCZ010000016.1  6459242-6459720
            1852-2012           JAXUCZ010000016.1  6459835-6459995
            2013-2105           JAXUCZ010000016.1  6460240-6460332
            2106-2178           JAXUCZ010000016.1  6460433-6460505
            2179-3433           JAXUCZ010000016.1  6460695-6461949
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3433
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..165
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Bap1"
                     /note="upstream in-frame stop codon"
     CDS             129..2312
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA1-associated protein 1; ubiquitin carboxyl-terminal
                     hydrolase BAP1; BRCA1 associated protein-1 (ubiquitin
                     carboxy-terminal hydrolase); Brca1 associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1
                     isoform 1"
                     /protein_id="NP_001423600.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVY
                     GFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLN
                     CSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLS
                     AVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLAT
                     AGEPYHDIRFNLMAVVPDRRVKYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKS
                     QESQLPEESKPASSKSPFGLEAGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKL
                     VVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQ
                     YSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKL
                     QESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSP
                     IRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDG
                     VLSPLALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEK
                     YSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQ
                     EGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ"
     misc_feature    141..827
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    141..827
                     /gene="Bap1"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5)
                     and BAP1; Region: Peptidase_C12_UCH37_BAP1; cd09617"
                     /db_xref="CDD:187738"
     misc_feature    294..308
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Arg-finger motif.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="cancer-causing mutation sites; other site"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    order(381..383,399..401,633..635,678..680)
                     /gene="Bap1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187738"
     misc_feature    381..383
                     /gene="Bap1"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01393; propagated
                     from UniProtKB/Swiss-Prot (D3ZHS6.2); other site"
     misc_feature    678..680
                     /gene="Bap1"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01393; propagated
                     from UniProtKB/Swiss-Prot (D3ZHS6.2); other site"
     misc_feature    945..1181
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1002..1004
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1215..1226
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: HBM-like motif.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    1233..1235
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1242..1433
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1308..1310
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1512..1694
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1599..1601
                     /gene="Bap1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1683..1685
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1731..1733
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1845..1994
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1875..1877
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    1908..2285
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with BRCA1.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    1911..1913
                     /gene="Bap1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92560; propagated from
                     UniProtKB/Swiss-Prot (D3ZHS6.2); phosphorylation site"
     misc_feature    2046..2180
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with YY1.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2049..2186
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2049..2186
                     /gene="Bap1"
                     /note="Ubiquitin carboxyl-terminal hydrolases; Region:
                     UCH_C; pfam18031"
                     /db_xref="CDD:465622"
     misc_feature    2217..2288
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Classical bipartite Nuclear localization signal
                     (NLS). /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2217..2225
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Interaction with nucleosomal DNA forming a DNA
                     clamp with ASXL1. /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2232..2309
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2259..2309
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Positively charged C-terminal extension (CTE).
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2271..2294
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Non-classical PY-nuclear localization signal
                     (PY-NLS). /evidence=ECO:0000250|UniProtKB:Q92560"
     misc_feature    2271..2288
                     /gene="Bap1"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZHS6.2);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q92560"
     exon            166..195
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..250
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..383
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..503
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..565
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..708
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..787
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..911
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1059
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1244
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1372
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1851
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2012
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2105
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2178
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..3433
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgt ggggctgaga agccccgagg gcggtgggcg
       61 ctcccggtgg gggcggcgcg gggttagcag ggcctggaca tggcgctgag agaccgctcc
      121 gcgggaagat gaataagggc tggctggagc tggagagtga cccgggcctc ttcaccctcc
      181 tggtggaaga tttcggtgtc aaaggggtgc aagtggagga gatctatgac cttcagagta
      241 aatgccaggg gcctgtatat ggatttatct tcctgttcaa atggatcgaa gagcgcaggt
      301 cccgccgcaa ggtttctacg ttggtggatg atacatctgt gattgatgat gacatcgtga
      361 atagcatgtt ctttgctcac cagctgattc ccaactcttg tgccactcac gccttgctga
      421 gcgtgcttct gaactgcagc aatgtggatt tggggcccac gctgagtcga atgaaggatt
      481 tcaccaaagg cttcagccct gagagcaaag gatatgcgat tggcaatgcc cctgaactgg
      541 ccaaggcaca taatagccat gccaggccag aaccacgtca ccttcctgag aaacagaatg
      601 gcctcagtgc agtgcggacc atggaggcgt ttcactttgt cagctatgtg cctatcacag
      661 gacggctctt tgaattggat gggttgaaag tctaccctat tgatcatggg ccctggggag
      721 aggatgagga gtggacagat aaagcccgaa gggtcatcat ggagcgaatc ggccttgcta
      781 ctgcagggga gccctaccat gacattcgct tcaacctgat ggcagtggtg cctgaccgca
      841 gggttaagta tgaggccagg ctgcatgtgc tgaaggggaa ccgacaaaca gtcctggagg
      901 ccctgcagca gctgattaga gtaacacagc cagagctgat tcagacccac aaatctcaag
      961 agtcacaact gcctgaggag agcaagccag ccagcagcaa gtctcccttt gggctagagg
     1021 cgggcagaac cccggcggcc tctgagtgca ctcacacaga tggtgcagag gaggtggctg
     1081 gttcgtgccc acaaactaca acccatagtc ctcccagcaa atctaagctg gtggtgaagc
     1141 cttcagggag cagcctcaat ggggttcccc caacccctac ccctattgtc cagcggctgc
     1201 cagcctttct agataatcac aattatgcca aatcccctat gcaggaggag gaagacctgg
     1261 cggcaggtgt gggccgcagc cgagttccag tccgacccca gcagtactct gatgatgagg
     1321 aggactatga ggatgaggag gaggatgtgc agaataccag ttctgccatc agatacaagc
     1381 ggaaggggac agggaagcca ggatcgttga gcaattcttc agatgggcag ctgtcagtgc
     1441 tgcagcccaa caccatcaat gtcttaactg agaagcttca agagtctcag aaagaccttt
     1501 caattcctct gtccatcaag actagcagtg gggctgggag tccagccgtg gctgtgccca
     1561 cacactcgca gccttcaccc acccctagca atgagagcac ggacacagcc tctgagattg
     1621 gcagtgcttt caactcaccc ttgcgctcac ccatccgctc agccaaccca acacggccct
     1681 ctagccctgt cacctctcac atctccaagg tgctctttgg agaagatgac agcctacttc
     1741 gtgttgactg catacgctac aaccgtgctg tccgtgacct gggtcctgtc attagcacgg
     1801 gcctgctgca ccttgctgag gatggtgtac tgagtcccct ggcactcaca gagggtggga
     1861 agggttcctc accttctacc agatcaagcc aaggcagcca ggggtccagc agcctagagg
     1921 agaaggaggt ggtggaagtc acagatagca gagacaagtc tgggctgaac aggtccagtg
     1981 agcccttgag tggagagaag tactcgccca aggagctgtt agcactgtta aagtgtgtag
     2041 aggccgagat tgcaaactat gaggcctgtc tcaaggagga ggtggagaaa aggaagaagt
     2101 tcaagattga tgaccagcga aggacccaca actatgatga gttcatctgc accttcatat
     2161 ccatgctggc tcaggaagga atgctggcca acctggtgga gcagaacatc tcagtgcggc
     2221 gccgccaagg ggtcagcatt ggtcggcttc acaagcagcg gaagcctgat aggcggaaac
     2281 gctctcgccc ctacaaggcc aaacgccagt gaggacctct agccctgact ctgcagcctc
     2341 tcttgccgca aggccctcac cagggccctt cactgttcga cttttccaag tattactgaa
     2401 tagttcagct agagctcagg ccctgggagt aggaatggga tgtgtattct gcattatgct
     2461 ctggggtctg gcagggacaa ggcagctcca taatgctcag gaagcagcag ctggaattgg
     2521 agggtgctgt ggcctccacg gccatctgag gagcagcagg atatatattc tacctgttgg
     2581 agatgtctat ttttttgact tttggccatc ttgccactgt attaacatgg ccagcttcct
     2641 gactctgctt tctctcccag cagctgtcat tctgctgggc ccaggtctct tataaccaca
     2701 gtaccagctg ggaaacccag aaggcattgg tcctggtgct ctagcaccag ccaccagcct
     2761 gtccttgttg tgaagaagct tggcctacta ctcttgattc cttctgggag agcgccaaac
     2821 tcagggacct ggctgctgag ctggaatggg catggggtat cctagtagga tgtacagcct
     2881 atcagggtcc cacagctatc gtggagacaa gtgtttgaac tgtcctcgta ccacccagac
     2941 ttgttagtga gtcagagcag ggctctgggg ctctttgcct tcagtgttgt ggccctggcc
     3001 gtgggcctac cttaggctcc taatctccgt ctctggggtc cagaggagcc actacttagc
     3061 ccctcagtat taccatgtct cctcttagga atgtcagagg cagggctgct cgaatgaggc
     3121 tggcactatt caattctccc gaccgtgcca gcttccttgg cctcatgcag gtactcaggg
     3181 taggggacag ggtcaagagg agttagaact tctgtgttcc catagggctt gatgccagtg
     3241 gggtagtaag cacagcactg cttcaagctc caggcccaga tagccctgtg ccctctgcta
     3301 gatacaggtg atccaagcag gccccttacc tgtacatagc aactgtcggg gggatggtac
     3361 agcagtccga cccgctatag tgtctgtaaa tactgaatca gtgagtgaag aataaaagtg
     3421 tgctaataag tga
//
LOCUS       NM_001436695            3116 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp),
            transcript variant 1, mRNA.
ACCESSION   NM_001436695 XM_063287407
VERSION     NM_001436695.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287407.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212041.1, SRR26360176.52831.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000005.1  135319012-135319175 c
            165-212             JAXUCZ010000005.1  135314949-135314996 c
            213-323             JAXUCZ010000005.1  135311284-135311394 c
            324-404             JAXUCZ010000005.1  135306753-135306833 c
            405-514             JAXUCZ010000005.1  135304577-135304686 c
            515-1495            JAXUCZ010000005.1  135302980-135303960 c
            1496-1575           JAXUCZ010000005.1  135298279-135298358 c
            1576-1661           JAXUCZ010000005.1  135297655-135297740 c
            1662-1735           JAXUCZ010000005.1  135297473-135297546 c
            1736-1924           JAXUCZ010000005.1  135296880-135297068 c
            1925-2091           JAXUCZ010000005.1  135296609-135296775 c
            2092-2148           JAXUCZ010000005.1  135296062-135296118 c
            2149-2226           JAXUCZ010000005.1  135295896-135295973 c
            2227-2355           JAXUCZ010000005.1  135295084-135295212 c
            2356-3116           JAXUCZ010000005.1  135294026-135294786 c
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3116
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..164
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2436
                     /gene="Nasp"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear autoantigenic sperm protein (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein isoform a"
                     /protein_id="NP_001423624.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAE
                     GQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIP
                     GLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETS
                     EDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLS
                     GQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSE
                     TKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANE
                     ETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWD
                     MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEA
                     HDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYE
                     KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMI
                     ASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSG
                     NEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     misc_feature    109..111
                     /gene="Nasp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    202..204
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    232..333
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    448..828
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    451..486
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    472..474
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    484..486
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    <493..1623
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <493..1623
                     /gene="Nasp"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    610..612
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    628..630
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    733..831
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    826..828
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    829..831
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    856..858
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    871..972
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    961..963
                     /gene="Nasp"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99MD9; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); acetylation site"
     misc_feature    1021..1023
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1066..1068
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1138..1596
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1240..1242
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1261..1263
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1297..1299
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1459..1461
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1474..1605
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
     misc_feature    1498..1500
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1507..1509
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1549..1551
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1558..1560
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    1600..1671
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1600..1671
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1687..1917
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1687..1917
                     /gene="Nasp"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    1693..1806
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1693..1806
                     /gene="Nasp"
                     /note="Region: SHNi-TPR; pfam10516"
                     /db_xref="CDD:402238"
     misc_feature    1693..1794
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    1693..1779
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1693..1779
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1696..1698,1705..1710,1717..1722,1726..1728,
                     1822..1824,1831..1836,1843..1848,1852..1857,1918..1920,
                     1927..1932,1939..1941)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1696..1698,1705..1710,1717..1722,1726..1728,
                     1822..1824,1831..1836,1843..1848,1852..1857,1918..1920,
                     1927..1932,1939..1941)
                     /gene="Nasp"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1792..1908
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1792..1908
                     /gene="Nasp"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1819..1920
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: TPR 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
     misc_feature    2053..2055
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2116..2118
                     /gene="Nasp"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2158..2433
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2182..2184
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2185..2187
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2215..2235
                     /gene="Nasp"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66HD3.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    2245..2247
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2302..2304
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2320..2322
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     misc_feature    2335..2337
                     /gene="Nasp"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q66HD3.1); phosphorylation site"
     exon            165..212
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            213..323
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            324..404
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            405..514
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1495
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1575
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1661
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1735
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1924
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2091
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2148
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2226
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2355
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..3116
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatctgcc attttctcta cctgagtaag tcatcgttgt ctggaattct ctcgttttct
       61 tcgcaggcag tatactgccc actggcccac cacctcaggg gaacgatggc cacagagtct
      121 acagccactg ctgccatcgc cgcggaactg gtttccgctg acaaagttga agatgctcct
      181 gctccttcta cctctgcaga taaaatggag agtctggatg tggatagtga agctaagaaa
      241 ctactgggat taggacagaa acatctggtg atgggtgaca ttccagcagc tgttaatgca
      301 ttccaagaag cagctagtct tttaggtaag aagtatggag aaacggctaa tgagtgtgga
      361 gaagccttct ttttttatgg gaagtcactt ctggagttgg ccagaatgga gaatggagtg
      421 ttgggaaatg ccttagaagg agtgcatgta gaagaggaag aaggagaaaa aacagaagat
      481 gaatctttgg tagaaaataa tgataatgta gatgaggaag caagggaaga gttgagagaa
      541 caggtttatg acgccatggg agaaaaagaa gccaaaaaag cagaaggcca gtctctgaca
      601 aagcctgaaa ctgataaaga acaggaaagt gaagtggaga agggtggaag agaagatatg
      661 gatataagtg agcctgcaga gaagctccag gaaaaagttg aatcgacttc aaagcagtta
      721 actgaatcct ctgaagaggc aaaagaagca gcaataccag gactgaatga agatgaggtc
      781 acttctggga agacagaaca ggaatcattg tgtactgagg aaggaaaatc catttctgga
      841 gtttatgttc aaaataaaga attcagagaa gcagtgcctc aggaggaggg agaggaaatg
      901 ataagcttag aaaaaaagcc aaaagaaact tcagaagatc agactattgg ggctccagaa
      961 aagcaggaca ctttaatgaa ggtggtagaa atagaagctg aaatagactc tgaagtcaag
     1021 tcagtggatg tgggtgggga ggagccgaag gatcagggag ctatctctga gagtgaacta
     1081 ggaaaggctg ttcttatgca actctcaggg caagatgttg aagtatcacc agtagtggct
     1141 gcagaggctg gatcagaagt ctctgagaag ccagggcagg agattacagt tcttcccaac
     1201 aatggtccag ttgttggaca atcatctgca ggagatcaaa ctcctagtga accacagaat
     1261 tctgcagaaa gactgtcaga aactaaagat ggcgcaagtg tagaggaggt caaggcagag
     1321 ctggttcctg aacaggagga agctatgcct cctgtagaag agtctgaggc agctggagat
     1381 ggggttgaga ccaaggtagc ccagagggcc acggagaaag cacctgaaga caaatttaag
     1441 atagctgcta atgaagagac acaagagaga gacgaacaga tgaaagaggg tgaagaaact
     1501 gaaggctcag aggaagaaga caaagaaaat gacaaggctg aagaaacaac aaatgaatca
     1561 gttcttgaaa aaaagactct tcaagaaaat gaagaagagg agattgggaa tttagaactt
     1621 gcctgggata tgctagattt agccaagatt atttttaaga ggcaagaaac aaaagaagcc
     1681 cagctttatg ctgcacaagc ccatcttaaa cttggagaag ttagtgttga atctgagaat
     1741 tatatccaag ctgtggagga gtttcaggct tgcctaagcc tgcaagagca gtatttggaa
     1801 gctcacgatc gtctccttgc ggagactcac taccagttgg gtttggccta tggttacaac
     1861 tctcagtatg atgaggctgt agcacagttt ggcaaatcta ttgacgtcat tgagaagaga
     1921 atggctgtac tacttgagca gatgaaggag gctgaaggat catttactga atacgagaaa
     1981 gaaatcgagg agctgaaaga actgctcccc gagattcggg agaagataga ggatgcaaag
     2041 gagtctcagc ggagtgggaa tgtagctgag ctggctctga aggccactct ggtcgagagc
     2101 tctacttcag gtttcactcc tagtggagct ggtgcctcgg tatccatgat tgccagtaga
     2161 aaaccaacag atggcgcttc ctcatcaaac tgtgtcactg atatttctca tcttgtcaga
     2221 aagaagagga aaccagagga agagagtccc cggaaagatg atgcaaagaa agctaaacca
     2281 gaaccagagg tgaatggagg cagtggagat gctgtctcca gtggaaatga agtttcagaa
     2341 aacatggagg cagaggctga gaatcaggct gagagccaga caacagcaga agggacagtg
     2401 gactctgcag ctacagttaa aagcactgca tgttaagagg cgagcagaac cttcctcctg
     2461 agggaaagtg gttttgtaca taatgtattt tttcactttt ggggattctt tttgtataac
     2521 tccaataaag attgtaggca acagctgaga ctttgatggc ttttttctta aaaatattgg
     2581 tggattgttt tggggcactc tatattgtgt atacatgcct tgtgttttgc tactgcacaa
     2641 cccacttcct gtctaatgtg gaggtgatca agttgatcaa ggcccttcat ctactggtgc
     2701 tatgtttcta tttccaaata tttggctgaa ttcaaatacc ttgtaagctt tccatggtgc
     2761 tgtccctgga tggggtctgc taaacaagaa ctggtagaaa tcagtttggt gctgaaaatg
     2821 gagcatggaa tatgacccag gtcttggttt gtgcctacct tctgttcacc tggtttccat
     2881 ttaaggccat aatatcctgc cctggcaaaa ctggcagaaa catgggaaat gattcctgag
     2941 gaaaactgtt gttagatact ccgtaggatc acactgtagt gggagacaag tagaagacta
     3001 tgattgagaa gtctgttacg ttattttctg tatagaaaga ttacaatatg tcaataagtg
     3061 gaattgttat attgtgcagt tttgtctata aaaataaata tgctaatttt aacaaa
//
LOCUS       NM_001436704            1557 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 163 (Ccdc163),
            transcript variant 3, mRNA.
ACCESSION   NM_001436704 XM_008763995
VERSION     NM_001436704.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_008763995.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.23862.1,
                                           SRR26360186.832014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               JAXUCZ010000005.1  135409506-135410015
            511-544             JAXUCZ010000005.1  135410176-135410209
            545-729             JAXUCZ010000005.1  135411011-135411195
            730-811             JAXUCZ010000005.1  135411301-135411382
            812-995             JAXUCZ010000005.1  135411658-135411841
            996-1063            JAXUCZ010000005.1  135412531-135412598
            1064-1131           JAXUCZ010000005.1  135413270-135413337
            1132-1235           JAXUCZ010000005.1  135413635-135413738
            1236-1297           JAXUCZ010000005.1  135414570-135414631
            1298-1557           JAXUCZ010000005.1  135415315-135415574
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1557
                     /gene="Ccdc163"
                     /note="coiled-coil domain containing 163"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
     exon            1..510
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="Ccdc163"
                     /note="upstream in-frame stop codon"
     CDS             433..1404
                     /gene="Ccdc163"
                     /note="isoform b is encoded by transcript variant 3;
                     transmembrane protein CCDC163"
                     /codon_start=1
                     /product="transmembrane protein CCDC163 isoform b"
                     /protein_id="NP_001423633.1"
                     /db_xref="GeneID:298442"
                     /db_xref="RGD:1564486"
                     /translation="MSRSSSWSDQLQAVLSSTDENMARIKQSLYPLRVSSTGDLADTW
                     ISPHHLPPQPGAQAQQPWALKTPILGESLSCTEAHSSSLWDEVTKLRSQLQTQTQVTE
                     ALRHSVQSLLKDREQQMFKISALEASLKLLQEGPKGRALLEQRLEGLRKELQGLRSQV
                     QELVQTQMRTRPGKFSTASGFHQELQNEHQLLWEESEILREELKLLRDQLSQHQELLL
                     EQMAEGRQVQARSWKTLEHLQSGQMGKVHTLEVTRTEAHDAQKEEPYLLSSEVSLPDC
                     DRSWELLKKLDRELQNNSLSNLEPSSSQFHAQDVGQEDLFLHGPRIF"
     misc_feature    <676..>1218
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <676..>1218
                     /gene="Ccdc163"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            511..544
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            545..729
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            730..811
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            812..995
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1063
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1131
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1235
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1297
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1557
                     /gene="Ccdc163"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgttgcc tgtggtctct gcaagaagtg gactcagttt cccgggtggc gctgcggcac
       61 cggttcgtaa atctcattct ccgcctacca gagtttgaac tcttgagcgg cacttgtcac
      121 tgatttagtg gtgataccgt ccttgatttg tggatgtctc aaccaaaatt cggttcattc
      181 tacactctgt atctgtgtat aatctaggtt tgttgttttg ttgttcttgt tgttttatct
      241 gctttccaag tactccgttc cgtagttcta gattcgcagt attggtatcg tactgtatct
      301 ggagccctag tatattcccg ctttcctcat ttccatctaa ctctgtggct tgtcctgggc
      361 tgttccgcgg gtatttcggt ctgggagagc aagaacagga gaagtcacgg acgcaatttc
      421 aagtgctcca ggatgagcag gagctctagc tggtctgatc agcttcaagc agttctcagt
      481 tcaactgatg aaaatatggc ccgaattaag cagagtttgt atcctcttcg agtttcctct
      541 acaggggacc tggctgacac ctggatttcc cctcatcact tgcctcctca gccaggggcc
      601 caagctcaac agccttgggc tctaaagact cccattcttg gtgagagtct gagctgtact
      661 gaagcccaca gctcctctct ctgggatgaa gttactaaac tccgctccca gcttcagact
      721 cagactcagg tgactgaggc actaaggcat tctgtgcaga gcctgttgaa ggatcgggag
      781 cagcagatgt tcaagatcag tgctctagaa gcatcactaa aactgctgca ggagggtcca
      841 aaagggagag ccctcctgga gcaacgcctg gaaggattga gaaaagaact gcaaggcctt
      901 cggagtcagg ttcaggagct agtccaaacc caaatgagaa caagaccagg aaagttcagc
      961 actgccagtg gctttcacca agagctgcag aacgagcacc aacttttgtg ggaagagtca
     1021 gagattcttc gggaggagct gaagttgctt cgagaccagc tgagccaaca tcaggagttg
     1081 ttactggaac agatggctga agggcgccag gttcaggccc gcagctggaa gacgttggaa
     1141 cacctacaga gtggccagat gggcaaggtt cataccttgg aggttaccag gacagaggcc
     1201 catgatgccc agaaggaaga gccctatctc ctcagctctg aagtcagtct cccagactgt
     1261 gaccgtagct gggaactttt aaagaaacta gatagggaac tccagaacaa ctccctttct
     1321 aacctggaac ccagcagctc tcagttccat gcccaggatg ttgggcaaga agacctgttc
     1381 cttcatggcc ccagaatctt ctagagtgac ctgtaagagc ttgtgagaaa atgagatgca
     1441 gcttctctcc aaggccgcct ttgcatcccc tctggtacgt gccctcttta cggaggcatc
     1501 tcactctcca gccattcctg ctccccagct aattcaaaat aaagtggctt agttctc
//
LOCUS       NM_001436700            6121 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus ERCC excision repair 6, chromatin remodeling
            factor (Ercc6), transcript variant 1, mRNA.
ACCESSION   NM_001436700 XM_006252734
VERSION     NM_001436700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6121)
  AUTHORS   Xu,Y., Wu,Z., Liu,L., Liu,J. and Wang,Y.
  TITLE     Rat Model of Cockayne Syndrome Neurological Disease
  JOURNAL   Cell Rep 29 (4), 800-809 (2019)
   PUBMED   31644904
  REMARK    GeneRIF: Rat Model of Cockayne Syndrome Neurological Disease.
REFERENCE   2  (bases 1 to 6121)
  AUTHORS   Yang,Z., Liu,C., Wu,H., Xie,Y., Gao,H. and Zhang,X.
  TITLE     CSB affected on the sensitivity of lung cancer cells to
            platinum-based drugs through the global decrease of let-7 and
            miR-29
  JOURNAL   BMC Cancer 19 (1), 948 (2019)
   PUBMED   31615563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6121)
  AUTHORS   West,H., Coffey,M., Wagner,M.J., McLeod,H.L., Colley,J.P.,
            Adams,R.A., Fleck,O., Maughan,T.S., Fisher,D., Kaplan,R.S.,
            Harris,R. and Cheadle,J.P.
  TITLE     Role for Nucleotide Excision Repair Gene Variants in
            Oxaliplatin-Induced Peripheral Neuropathy
  JOURNAL   JCO Precis Oncol 2, 1-18 (2018)
   PUBMED   35135151
REFERENCE   4  (bases 1 to 6121)
  AUTHORS   Luo,S.S., Liao,X.W. and Zhu,X.D.
  TITLE     Prognostic Value of Excision Repair Cross-Complementing mRNA
            Expression in Gastric Cancer
  JOURNAL   Biomed Res Int 2018, 6204684 (2018)
   PUBMED   30417012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6121)
  AUTHORS   Pascucci,B., Fragale,A., Marabitti,V., Leuzzi,G., Calcagnile,A.S.,
            Parlanti,E., Franchitto,A., Dogliotti,E. and D'Errico,M.
  TITLE     CSA and CSB play a role in the response to DNA breaks
  JOURNAL   Oncotarget 9 (14), 11581-11591 (2018)
   PUBMED   29545921
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6121)
  AUTHORS   Dianov,G., Bischoff,C., Sunesen,M. and Bohr,V.A.
  TITLE     Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome
            group B cells
  JOURNAL   Nucleic Acids Res 27 (5), 1365-1368 (1999)
   PUBMED   9973627
REFERENCE   7  (bases 1 to 6121)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Cockayne syndrome group B protein enhances elongation by RNA
            polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11205-11209 (1997)
   PUBMED   9326587
REFERENCE   8  (bases 1 to 6121)
  AUTHORS   van der Horst,G.T., van Steeg,H., Berg,R.J., van Gool,A.J., de
            Wit,J., Weeda,G., Morreau,H., Beems,R.B., van Kreijl,C.F., de
            Gruijl,F.R., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Defective transcription-coupled repair in Cockayne syndrome B mice
            is associated with skin cancer predisposition
  JOURNAL   Cell 89 (3), 425-435 (1997)
   PUBMED   9150142
REFERENCE   9  (bases 1 to 6121)
  AUTHORS   Selby,C.P. and Sancar,A.
  TITLE     Human transcription-repair coupling factor CSB/ERCC6 is a
            DNA-stimulated ATPase but is not a helicase and does not disrupt
            the ternary transcription complex of stalled RNA polymerase II
  JOURNAL   J Biol Chem 272 (3), 1885-1890 (1997)
   PUBMED   8999876
REFERENCE   10 (bases 1 to 6121)
  AUTHORS   Henning,K.A., Li,L., Iyer,N., McDaniel,L.D., Reagan,M.S.,
            Legerski,R., Schultz,R.A., Stefanini,M., Lehmann,A.R., Mayne,L.V.
            and Friedberg,E.C.
  TITLE     The Cockayne syndrome group A gene encodes a WD repeat protein that
            interacts with CSB protein and a subunit of RNA polymerase II TFIIH
  JOURNAL   Cell 82 (4), 555-564 (1995)
   PUBMED   7664335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252734.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.18370.1,
                                           SRR26360186.2394780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000016.1  7771357-7771417
            62-493              JAXUCZ010000016.1  7775249-7775680
            494-614             JAXUCZ010000016.1  7777319-7777439
            615-726             JAXUCZ010000016.1  7779273-7779384
            727-1453            JAXUCZ010000016.1  7785040-7785766
            1454-1579           JAXUCZ010000016.1  7797795-7797920
            1580-1738           JAXUCZ010000016.1  7803448-7803606
            1739-1874           JAXUCZ010000016.1  7809471-7809606
            1875-2045           JAXUCZ010000016.1  7816868-7817038
            2046-2222           JAXUCZ010000016.1  7817456-7817632
            2223-2339           JAXUCZ010000016.1  7821768-7821884
            2340-2435           JAXUCZ010000016.1  7823617-7823712
            2436-2651           JAXUCZ010000016.1  7827032-7827247
            2652-2762           JAXUCZ010000016.1  7827603-7827713
            2763-2882           JAXUCZ010000016.1  7828737-7828856
            2883-2977           JAXUCZ010000016.1  7829217-7829311
            2978-3123           JAXUCZ010000016.1  7830767-7830912
            3124-3798           JAXUCZ010000016.1  7830992-7831666
            3799-4003           JAXUCZ010000016.1  7836688-7836892
            4004-4076           JAXUCZ010000016.1  7837600-7837672
            4077-6121           JAXUCZ010000016.1  7838451-7840495
FEATURES             Location/Qualifiers
     source          1..6121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..6121
                     /gene="Ercc6"
                     /note="ERCC excision repair 6, chromatin remodeling
                     factor"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
     exon            1..61
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            62..493
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Ercc6"
                     /note="upstream in-frame stop codon"
     CDS             72..4496
                     /gene="Ercc6"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     excision repair protein ERCC-6; excision repair
                     cross-complementing rodent repair deficiency,
                     complementation group 6; excision repair
                     cross-complementation group 6"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6 isoform 1"
                     /protein_id="NP_001423629.1"
                     /db_xref="GeneID:306274"
                     /db_xref="RGD:1311509"
                     /translation="MPHEEIPNSTQPQGQDWLPGQHVSADRDIPAGQETAGDSEAGKC
                     LSSPSCDHGPSTSAEACVLAATRWGPALLHIDRHQIPAVEPSAQALELQGLGVDVYDQ
                     AVLEEGVLQQVDSAMHEASRVAQRADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQ
                     AASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAILGGAEVHVELDHGSLEEEDA
                     EPGPSCLGSMLMPAQESAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYL
                     ADQAQLSFKRKKQAANKRTAKKAVVVSESSRGPNETKPNQRSQALSQTDKRLKKHIRK
                     LQRRALQFQGKVGLQRGKRPLEPEERPGAEGDTEGEESGSSPTDGEEEEEQEEEGVAV
                     LSSDDISYELKPLRKGQKYEKKVPVQEIDDDFFPSSEEEDEAVEGRGGGRKVSRRPDD
                     GDEDYYKQRLRRWNRLRLQDKEKLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTG
                     VRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTLIV
                     CPTTVMHQWVKEFHTWWPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSYSYIRL
                     MQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSL
                     FDFTFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRM
                     KSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGENQIFSGLVALRK
                     ICNHPDLFSGGPKNTSALPEDGLEEEQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFS
                     QSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLG
                     VNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIF
                     KQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQGTETSAIFAGTGSNIQTLKCHF
                     KKRTPPVLQMDPKRKKPLVSDTSVNGATVMEEKSQGSGATGSVPSTESGPLKSDRHTD
                     GSRASSVGFGEEADAGSTLEHLSGLSGDSPAVDHTSRLSAVASTSEKQGSSYEGECCQ
                     AQTGPVHLSEQTEGHFSKHKSKRKHDAAEEETTEKCPQPKQKAKNSRHHRDAKFEGTR
                     VPHLVKKRRYHQQTTEQESGAKDRSSDDYVLEKLFKKSVGVHSVVKHDAIIDGSSPDY
                     VLVEAEANRVAQDALKALRLSRQQCLGATSGVPTWTGHRGISGAPAGVKKRFGQKRNS
                     SLPVQRPSSLTERTQNMKKEGEAHTAEHFSGKEDGASSSGAPSSSSLLARMRARNHMI
                     LPERLESDGEQLAGAAAAAAPPCSTEHDALLVDMRNFIAFQAQVDGQASTQEILQAFE
                     SKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEYC"
     misc_feature    318..548
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    318..548
                     /gene="Ercc6"
                     /note="coiled-coil domain located near the N-terminus of
                     human Excision Repair Cross Complementing 6 (ERCC-6) and
                     related proteins; Region: cc_ERCC-6_N; cd21397"
                     /db_xref="CDD:411064"
     misc_feature    order(411..413,423..425)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    order(411..413,423..425)
                     /gene="Ercc6"
                     /note="Mg binding site [ion binding]; other site"
                     /db_xref="CDD:411064"
     misc_feature    1017..3014
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    1017..3014
                     /gene="Ercc6"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    4275..4490
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    4275..4490
                     /gene="Ercc6"
                     /note="winged-helix domain (WHD) found in cockayne
                     syndrome group B (CSB) and similar proteins; Region:
                     CSB_WHD; cd22254"
                     /db_xref="CDD:439329"
     misc_feature    order(4275..4280,4287..4292,4296..4301,4308..4310,
                     4320..4325,4338..4343,4428..4430,4482..4490)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     misc_feature    order(4275..4280,4287..4292,4296..4301,4308..4310,
                     4320..4325,4338..4343,4428..4430,4482..4490)
                     /gene="Ercc6"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:439329"
     exon            494..614
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            615..726
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1453
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1579
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1738
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1874
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2045
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2222
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2339
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2435
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2651
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2762
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2882
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2977
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3123
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3798
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..4003
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4076
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..6121
                     /gene="Ercc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctacgctt tgtcgcggcc gtggcgacga agatttcgtc tgggcggccg cgtggtcctg
       61 gtttgtagag gatgccccat gaggaaatcc ccaactccac tcaacctcag ggccaagact
      121 ggttaccagg tcagcatgtc agtgctgaca gagacatacc agctgggcag gagactgctg
      181 gggactcaga ggcggggaag tgcctctcct ctccttcctg tgaccatggg ccgtccacat
      241 ctgctgaagc ttgtgtactg gcagccacaa ggtgggggcc cgccctgctg cacatcgacc
      301 ggcatcagat tcctgcggtg gagcccagtg ctcaggccct ggagctgcag ggcctgggtg
      361 tggacgtcta cgaccaggcc gtcctggagg aaggtgtgct tcagcaggtg gacagtgcaa
      421 tgcatgaggc cagccgtgtg gcccagcgtg ctgatgcgga gaaagagtat cagtcagtcc
      481 tggacgacct catgtcatgt acaacatccc tgaggcaaat caataaaatt atagagcaac
      541 ttagccctca agctgccagc aacagagaca tcaacaggaa actagattct gtgaaacgac
      601 agaagtacaa caaggaacaa cagctaaaga agataactgc aaaacagaaa cgtctccagg
      661 ccattctcgg aggagcggag gtccatgtgg aactggatca tggcagctta gaggaggaag
      721 atgcagagcc aggcccatca tgtctcggca gtatgctcat gcctgcccag gagagcgcct
      781 gggaagaact tatccgcact ggccagatga caccgttcgg taccccagcc cctcagaaac
      841 aggagaaaaa gcctagaaaa ataatgctca atgaagcatc aggctttgaa aaatatttgg
      901 cagaccaagc acaactttct tttaaaagga aaaaacaagc tgctaataaa agaacagcta
      961 aaaaagctgt ggttgtatct gagtcaagcc gaggaccaaa tgaaactaag ccaaaccaga
     1021 gaagccaagc gctctctcag acagacaagc gcctgaagaa gcacatcagg aagctccaga
     1081 ggagggcgct gcagttccag ggcaaagtgg gattgcaaag ggggaagaga cctctggagc
     1141 ctgaggagag gccaggggca gagggagaca ctgagggtga ggagtctggg tcctctccca
     1201 ctgatgggga ggaagaggaa gaacaagagg aggaaggggt agccgttctg tcttccgatg
     1261 acattagcta tgaactgaag cctcttcgga aaggacaaaa atacgagaag aaagtcccag
     1321 tgcaggagat cgacgatgac ttctttccaa gttctgagga ggaagatgaa gctgtggaag
     1381 gaagaggagg aggccgcaag gtctccaggc gcccagacga tggagatgag gattattata
     1441 aacaacgatt aaggaggtgg aataggctga ggctgcagga caaagagaag ctgaagcttg
     1501 aagacgattc tgaggagagc gatgctgagt ttgacgaagg tttcaaagtg ccgggttttc
     1561 tgttcaaaaa gctctttaag tatcagcaga caggtgttag gtggctgtgg gaattgcact
     1621 gccagcaggc aggaggaatt ctgggagacg aaatgggatt gggcaagacc atccagataa
     1681 ttgccttctt ggcaggtctg agctacagca agatcaggac tcgcggttca aattacaggt
     1741 tcgagggact cggccccact ctcattgtct gcccaacgac agtgatgcat cagtgggtga
     1801 aagaattcca cacgtggtgg cctccattca gagtggcgat tctgcacgaa acaggctcct
     1861 gtgcccacag aaaggagagg ctggttcgag atattgttca ttgtcatgga gttttgataa
     1921 cttcgtattc ctacattcga ctgatgcaag acgacattag caggcatgac tggcactacg
     1981 tcatcttaga cgaaggacat aaaattcgaa atccaaatgc tgcagtcacc cttgcttgca
     2041 aacagttccg gacaccccat cggatcatct tgtcgggctc accgatgcag aataacctgc
     2101 gagagctgtg gtcactcttc gactttacct tcccaggaaa gctaggcacg ttgcctgtgt
     2161 tcatggagca gttctctgtc cccatcacca tgggggggta ctccaatgct tccccagtac
     2221 aggttaaaac tgcctataag tgtgcgtgtg tcttgagaga cacgataaac ccgtacctac
     2281 tgcgaagaat gaaatcagat gtcaagatga gcctttcgct gccagataaa aatgaacagg
     2341 tcttattttg ccgtctaact gatgagcagc ataaagtcta ccagaatttc atcgattcca
     2401 aagcagttta caggattctc aatggagaga atcagatttt ctctggactt gtagctctga
     2461 ggaagatctg caaccaccct gacctctttt ctggcggtcc caagaacacc agtgctcttc
     2521 cagaggatgg actggaggag gagcagttcg gatactggaa acgctctggg aaaatgattg
     2581 ttgttgagtc tttgctgaaa atctggcaca agcagggtca gcgggtgctg ctgttttccc
     2641 agtcaaggca gatgctgcac atactggaag tgttcctgag agcccacaag tattcctatc
     2701 tcaagatgga tgggaccact accatagcat ccaggcagcc gctgattaca aaatacaatg
     2761 aggacacgtc catctttgtc tttcttctga ccacacgggt gggcggctta ggagtgaacc
     2821 tgaccggggc caacagagtc atcatctacg accctgactg gaatccaagc accgacacac
     2881 aggcacggga gcgagcatgg aggatcggcc agaagaagca ggtgactgtc tacaggcttc
     2941 tgacggccgg caccatagag gaaaagatct atcaccgaca aatcttcaag caatttttga
     3001 caaacagagt gctaaaagac cctaaacaaa ggcgcttttt caagtccaat gatctctatg
     3061 agctgtttac tctgactagt cctgatgcct cccagggcac tgaaacaagt gctatttttg
     3121 caggaaccgg atctaatatt cagacactga aatgccattt taaaaagagg actccgccag
     3181 tcctacaaat ggatcccaaa cgcaagaagc ccctggtttc tgacacatct gtaaatggtg
     3241 ccactgtgat ggaagaaaaa tctcaggggt caggagctac gggcagtgtc ccttctacag
     3301 aaagtggccc tttgaaaagt gaccgtcaca cagatgggag cagagccagc agtgttggtt
     3361 ttggagaaga ggcagatgca gggtccacgc tggagcatct ctcagggctg agtggagatt
     3421 ctccagcagt tgaccacaca tccaggctgt cagctgtggc gagcaccagt gagaagcagg
     3481 gctcttccta tgaaggggag tgctgccagg ctcagacggg acctgttcac ctgagtgaac
     3541 aaacggaagg tcatttctct aagcacaaat caaaaaggaa acatgatgca gcggaggaag
     3601 agaccacaga gaagtgtcca cagcccaagc aaaaggccaa gaactccagg catcacagag
     3661 atgctaagtt tgagggaact cgagtcccac acctggtgaa gaagaggcgg taccatcagc
     3721 aaaccactga gcaggagagc ggagccaagg accggagcag tgatgattat gttttggaaa
     3781 agcttttcaa aaaatcagtg ggcgtgcaca gcgtcgtgaa gcatgatgcc atcatagatg
     3841 ggtccagtcc ggattatgtg ctggtggagg cagaagccaa cagagtggct caggatgcct
     3901 tgaaagctct gaggctctct cgtcagcagt gcctgggggc aacatctggt gttcccacct
     3961 ggactggcca caggggtatt tccggtgcac cagcaggagt aaagaaaagg ttcggtcaga
     4021 aaaggaactc cagcctccct gtgcagcgtc cttcgtcgct aacagagaga actcagaaca
     4081 tgaagaagga gggggaagct cacaccgctg agcacttcag tggcaaagaa gatggagcat
     4141 cgtcgtctgg agcccccagt tcctcctcgc tcttggccag aatgcgagca cgaaaccaca
     4201 tgattttgcc ggagcgtttg gagagtgacg gcgagcagct tgctggggct gcggctgcgg
     4261 ctgcgcctcc ctgcagcaca gagcacgacg cccttctggt ggacatgagg aacttcattg
     4321 ctttccaggc tcaggtggat ggccaggcca gcactcagga aatcctacag gcgttcgaat
     4381 ccaagctgtc tgtggcacag tcctgtgtct tccgagaact actgaggaat ctgtgcaatt
     4441 tccatagaac tcctggtggt gaagggattt ggaaactgaa gccagagtac tgctaacagt
     4501 gctgcttcct gaactttttc aaataggaat cttggctcgt gtgtgtgtgt gtgtgtgtgt
     4561 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt aagtgtataa gagtatagct gcacttggtg
     4621 tttactgtgt catctacctc aagactaaaa cttgaagaag aaaataattg gagggttttt
     4681 gtttggtttg gttttctttt ggtggcacta tgaattgtta taaaaccagg gacctagcag
     4741 ttgtttaatg gagcaaatac attacttaac ccaagagatg ctgtcaggga gcacattctg
     4801 tctaagagta gatcttgatt cttcttattg gtgctgggaa cgtgtcttct ctttatccac
     4861 gccatcccat aggggacttc acggtatctg ataaccttag taccttgata cagtaagtat
     4921 ttatgaccca ctggccacat acagaaagat ccttgctatc tgtcaaatca ttccctacga
     4981 ttaattcttc acagtacttt taaagtagca ggtttgggtt ttactgttgg tctgttttaa
     5041 atgttgctaa cgacagtctg gtgccttgca cgtgctaagc gagctaagcg agcatgtgct
     5101 tcaccaccag gttccatcca gttcatacat acgcatcaac gaaggacgtc tggcttttct
     5161 tctctgtcat cattgtgtaa ggaaggggga ggggtttgtt taaataggtc agtaacgtct
     5221 ggacttcagc acttggctca gaaggcagtc acacattttt tcttctagtt gtcagcctac
     5281 aggggaatgg cgttgttctt gtcccaggct gactcctgat ctgactcact ggtgtgagct
     5341 tttgtgctgt gtctgtaatg cctgagatct acgtcagact gagctggaga aggtataaac
     5401 acctcttaga tggcaagtga cctcccatga gtaagggagg agtccatggt ccagctctgc
     5461 cactgacctg cccagcctgg ggaggttgac tctgtaaaca cggttttcca gccaagctgg
     5521 gaaactcaga gaccagtgct ctaggttaaa gtacttttta acaatgaaca atacctttat
     5581 acattaagct gcaatctgat tttttgaaca tgaaatactt tgtgtggtgt aaatagaatt
     5641 aatgtgttaa acatgttaaa taattgtaaa taaaagactt taaaattcca gcttttactg
     5701 tattgtcact gttaaagcct tcaagcgctc ctgccttccc accctgtgcc gatggagctg
     5761 cggttccgga gccctgtgca gttgcccagg catttgcatg gctgctggcg tgggctgctg
     5821 cttcgcttct gtgtgtcccc tgggccagtc actgctcagc tgacaatcgt ttctcagcct
     5881 ccctgcagcg aagtgtggcc gcatgacagt tccaggcagt gagatggaaa acgccaactt
     5941 gaagcttaca caaagtcatg gcatgcacgc ccctgaaagt tccctgtttt gctggtcggg
     6001 atgtgtatga aagcctcggg tttccgggta tttcaagaga gggtggttgg tctgccagtc
     6061 aagaacagct gtccgtgacc agatactttg gagtgaaata aatgaatctt atttaacact
     6121 g
//
LOCUS       NM_001436712            5275 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 3 receptor (Csf3r),
            transcript variant 1, mRNA.
ACCESSION   NM_001436712 XM_008764007
VERSION     NM_001436712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5275)
  AUTHORS   Zhang,E., Lee,S., Yi,M.H., Nan,Y., Xu,Y., Shin,N., Ko,Y., Lee,Y.H.,
            Lee,W. and Kim,D.W.
  TITLE     Expression of granulocyte colony-stimulating factor 3 receptor in
            the spinal dorsal horn following spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Mol Med Rep 16 (2), 2009-2015 (2017)
   PUBMED   28656207
  REMARK    GeneRIF: the expression of GCSFR in neurons following peripheral
            nerve injury may be involved in the induction and maintenance of
            neuropathic pain through the STAT3 and TRPV1 signaling pathway.
REFERENCE   2  (bases 1 to 5275)
  AUTHORS   Aref,S., El-Ghonemy,M., Abouzeid,T., El-Sabbagh,A. and El-Baiomy,M.
  TITLE     Prevalence and impact of colony stimulating factor 3 receptor
            (CSF3R) mutations among Egyptian acute myeloid leukemia patients
  JOURNAL   Leuk Res 38 (6), 722-725 (2014)
   PUBMED   24746896
REFERENCE   3  (bases 1 to 5275)
  AUTHORS   Fleischman,A.G., Maxson,J.E., Luty,S.B., Agarwal,A., Royer,L.R.,
            Abel,M.L., MacManiman,J.D., Loriaux,M.M., Druker,B.J. and
            Tyner,J.W.
  TITLE     The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in
            mice that is responsive to therapeutic JAK inhibition
  JOURNAL   Blood 122 (22), 3628-3631 (2013)
   PUBMED   24081659
REFERENCE   4  (bases 1 to 5275)
  AUTHORS   Kosmider,O., Itzykson,R., Chesnais,V., Lasho,T., Laborde,R.,
            Knudson,R., Gauthier,A., Merlevede,J., Ades,L., Morabito,M.,
            Fontenay,M., Tefferi,A., Droin,N. and Solary,E.
  TITLE     Mutation of the colony-stimulating factor-3 receptor gene is a rare
            event with poor prognosis in chronic myelomonocytic leukemia
  JOURNAL   Leukemia 27 (9), 1946-1949 (2013)
   PUBMED   23774674
REFERENCE   5  (bases 1 to 5275)
  AUTHORS   Hanumanthu,V.S. and Pirruccello,S.J.
  TITLE     GCSF-R expression in myelodysplastic and myeloproliferative
            disorders and blast dysmaturation in CML
  JOURNAL   Am J Clin Pathol 140 (2), 155-164 (2013)
   PUBMED   23897249
REFERENCE   6  (bases 1 to 5275)
  AUTHORS   Semerad,C.L., Poursine-Laurent,J., Liu,F. and Link,D.C.
  TITLE     A role for G-CSF receptor signaling in the regulation of
            hematopoietic cell function but not lineage commitment or
            differentiation
  JOURNAL   Immunity 11 (2), 153-161 (1999)
   PUBMED   10485650
REFERENCE   7  (bases 1 to 5275)
  AUTHORS   Otsuji,W., Tanase,S., Yoshida,S. and Bawden,J.W.
  TITLE     The immunohistochemical localization of the interferon-gamma and
            granulocyte colony-stimulating factor receptors during early
            amelogenesis in rat molars
  JOURNAL   Arch Oral Biol 44 (2), 173-181 (1999)
   PUBMED   10206335
REFERENCE   8  (bases 1 to 5275)
  AUTHORS   Hermans,M.H., Ward,A.C., Antonissen,C., Karis,A., Lowenberg,B. and
            Touw,I.P.
  TITLE     Perturbed granulopoiesis in mice with a targeted mutation in the
            granulocyte colony-stimulating factor receptor gene associated with
            severe chronic neutropenia
  JOURNAL   Blood 92 (1), 32-39 (1998)
   PUBMED   9639496
REFERENCE   9  (bases 1 to 5275)
  AUTHORS   Dong,F., Dale,D.C., Bonilla,M.A., Freedman,M., Fasth,A.,
            Neijens,H.J., Palmblad,J., Briars,G.L., Carlsson,G., Veerman,A.J.,
            Welte,K., Lowenberg,B. and Touw,I.P.
  TITLE     Mutations in the granulocyte colony-stimulating factor receptor
            gene in patients with severe congenital neutropenia
  JOURNAL   Leukemia 11 (1), 120-125 (1997)
   PUBMED   9001427
REFERENCE   10 (bases 1 to 5275)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_008764007.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7667.1,
                                           SRR26360194.2138570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JAXUCZ010000005.1  143583210-143583447
            239-329             JAXUCZ010000005.1  143584764-143584854
            330-413             JAXUCZ010000005.1  143586042-143586125
            414-713             JAXUCZ010000005.1  143588148-143588447
            714-837             JAXUCZ010000005.1  143590265-143590388
            838-1025            JAXUCZ010000005.1  143590587-143590774
            1026-1195           JAXUCZ010000005.1  143592025-143592194
            1196-1349           JAXUCZ010000005.1  143592279-143592432
            1350-1429           JAXUCZ010000005.1  143593262-143593341
            1430-1643           JAXUCZ010000005.1  143593661-143593874
            1644-1826           JAXUCZ010000005.1  143594985-143595167
            1827-1928           JAXUCZ010000005.1  143595483-143595584
            1929-2075           JAXUCZ010000005.1  143597332-143597478
            2076-2216           JAXUCZ010000005.1  143597586-143597726
            2217-2307           JAXUCZ010000005.1  143600615-143600705
            2308-2389           JAXUCZ010000005.1  143600867-143600948
            2390-5275           JAXUCZ010000005.1  143601497-143604382
FEATURES             Location/Qualifiers
     source          1..5275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5275
                     /gene="Csf3r"
                     /note="colony stimulating factor 3 receptor"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
     exon            1..238
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            239..329
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Csf3r"
                     /note="upstream in-frame stop codon"
     exon            330..413
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..2866
                     /gene="Csf3r"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; granulocyte colony-stimulating factor receptor;
                     colony stimulating factor 3 receptor (granulocyte)"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     isoform a precursor"
                     /protein_id="NP_001423641.1"
                     /db_xref="GeneID:298518"
                     /db_xref="RGD:1309114"
                     /translation="MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLA
                     SCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFC
                     LVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKL
                     CIDPMDVVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQECELRYQPQLE
                     GANWTLVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWSPGLQLRPTIKA
                     PTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCPDGQGRIMHLCN
                     TTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLHAMAQDLGSIWV
                     DWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHPFQLYRITVAPL
                     YPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIF
                     WTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNSTGLTLMTMALDS
                     SDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLSAWVPTIMTEET
                     FQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAYVLQGDPREISN
                     QFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPKSYENIWFHSRP
                     QETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     sig_peptide     350..424
                     /gene="Csf3r"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    419..682
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    419..682
                     /gene="Csf3r"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    716..1012
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    716..1012
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    1646..1912
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1646..1912
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1886..1891,1895..1900)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1886..1891,1895..1900)
                     /gene="Csf3r"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1934..1936,2126..2128,2171..2173)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1934..1936,2126..2128,2171..2173)
                     /gene="Csf3r"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    1943..2176
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1943..2176
                     /gene="Csf3r"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     exon            414..713
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            714..837
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1025
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1195
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1349
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1429
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1643
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1826
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1928
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2075
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2216
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2307
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2389
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..5275
                     /gene="Csf3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggagag gagacaagag aagagagagc aaacgtgggg gctgggcaca gcgccccagc
       61 cccaatgtaa gtagggggag ggcggagccc tgaaggcctc agaccattcc ccagccctga
      121 cagggtcaca tcagggggcc caagacaggg gatccttcgg aaatggaagg ctctctgtgt
      181 gtatagcatc aggaaagtca gacagctgga tctctttggg aacaggagct gagctcagca
      241 ttgctgagac atgagcataa gccccttttc ccaaatggag aaattgagac tcagaaaggt
      301 gaagtaaccc atccaagttc accaggcagg taaacaccaa gctggcgaaa tggtggggct
      361 gggagcctgc aacctgactg gagttaccct gattgtcttg ctactcccca gaagtctgga
      421 gggctgcggg caaatcagga tctcaccccc cattgtccat cttggggatc ctgtcctggc
      481 ctcctgcacc atcagcccaa actgcagcaa actggaccga cagccaaaga tcctatggag
      541 actgcaagat gaaccaaacc agcctgggga cagacagcat cacctgcctg acgggtccca
      601 ggagtccatc atcactctgc ctcatctgaa ctacactcag gccttcctct tctgcttggt
      661 gccatggaac aacagcttcc aggtcctgga tcaagctgag cttcgtgcag gctatcctcc
      721 tgccagcccc tccaacctat cctgcctcat gtacctcacc accaacagcc tggtctgcca
      781 gtgggagcca ggccccgaga cccacctgcc cactagcttc atcctaaaga gcttcaggag
      841 ccgcaccggc tgtcagtacc aggggggcac catcctggac tgtatgccca agaagagaca
      901 cagcaactgc tccatccccc gcaaacactt gcttctgtac cagaatatgg tcatctgggt
      961 gcaagcggag aatatgctag ggtccagcga gtccccaaag ctgtgcattg accccatgga
     1021 tgttgtgaaa ttggagcctc ccatgctgca ggccctggac attggccatg atatagtctc
     1081 tcgccagcct ggctgcctat ggctgagctg gaagccatgg aagcccagtg agttcatgga
     1141 gcaggagtgt gaactccgtt accagccaca gcttgaagga gccaactgga ccctggtgtc
     1201 ccacctgcct tccagcacgg accggttcga gctctgcagc cttcatcaag ccccagtcta
     1261 caccctacag ttgcgatgca tccgctcatc tctgcctgga ctctggagca gctggagccc
     1321 tggccttcag ctgaggccca ccattaaggc ccccaccatc agactggaca catggtggca
     1381 gaagaagcat ctggatcctg agacagtgag aatgcagctg ttctggaagc caacacccct
     1441 gcagaaagac agtggacaga tccagggcta cctgctctcc tggagttgcc cagatgggca
     1501 agggcggatc atgcacctct gtaacaccac agagctcagc tgcaccttcc acctgccctc
     1561 agaggcccag aacgtgaccc ttgtggccta caactcggcg gggacctcct cccctactct
     1621 ggtggttttc ctggagcacg aaggtccagc tgtgaccagc ctgcatgcca tggcccaaga
     1681 ccttggtagc atctgggtag actgggaagc ccccagcctt ctgcctcagg gctatctcat
     1741 tgagtggggc ccggattccc acaaatacag caataattcc tggaggatag agcccaatgg
     1801 gaacaccact ggaattctgt tagaggacaa tatacatccc tttcaactct acagaatcac
     1861 agtggctccc ctgtacccag gcaccgtggg accccctgta aatgtctaca cctactctgg
     1921 agagaaagcc cttcctcatg ctccagagct atatctaaag catgttggca ggacctgggc
     1981 acagttggag tgggtacctg agaccccttg gctggggatg atacccctca ccaactacac
     2041 catcttctgg accgatgctc gggaccactc cttctctgtc accctgaaca tctcctttca
     2101 tgactttgtc ctggaccacc tgaaacctgc cagtttgtat cacgtctacc tcatggccac
     2161 cagccgggca gggtccacca acagtacagg ccttaccctg atgaccatgg ccctagattc
     2221 atctgatgta aacattttcc tgggcatact ttgcttcgta cttttgtcca ttacctgtgc
     2281 aactgcctgg ttctgctgca agcaaagcag aaagactttc ttctggccaa atgtgccaga
     2341 cccagcccac agcagtctga gcgcctgggt gcccaccatc atgacagagg aaaccttcca
     2401 gctgcccagc ttctggggct ccagtgtgcc gtcaatcacc aagatcactg aactggagga
     2461 ggacaagaaa ccgacccact gggatcccag tgagagctct gggactggga gccttccagc
     2521 cgtggttcag gcttacgtgc tccaaggaga cccaagagaa atttccaacc agttccagcc
     2581 tccctctagc actaatgacc aggttctcta tggtcaggtg cttgggagcc ccaccagccc
     2641 agaagtagtg ggataccttc ggtgtgactc cactcagccc ctcttgggag gccccacacc
     2701 cagccctaaa tcctatgaaa acatctggtt ccattcaaga ccccaggaga cctttatacc
     2761 ccaacctcca agccaggaag atgactgtgt ctttggacct ccatttgatt tccccctctt
     2821 ccaggggctc caggtccatg gagttgaaga acaagggggt ttctaggact tttggggtcc
     2881 ttacatcctg aaggccctgg cctattcagg aaagatccca ccactaatat ctactggtcc
     2941 tgagggaaac agaaaggccc tatttgtctc cagctgtggc ccctaggacc tctccttcac
     3001 tctaacctcc acaggctaca cccctaggtc tttctcacac tccaaggtcc agatacatac
     3061 tgtttacagc ccactagtca ccttgtgtct ctcatataat ttcagtccgt taaactgagt
     3121 gtaggttttg agcagggact agcacgttca caaatcctgg ctggacgtag tgatacatgc
     3181 ctagcatccc aactcaaacg tttgggagga agatgcagga ggattgcaag ttccaggcca
     3241 gcctgggcta tatgaagaga tcctgcctca gaaattaagc aaaagccaaa taaaattttt
     3301 ttattacatt tactttttgt tggtggggtt gggggctcac aggcaaaggt cagacacctt
     3361 aagggaatta actctggcct ccagcctgtg gattttggga ggtgaacgta aggtttagtg
     3421 gcaagcatct ttccccaggg aggcatttca ctagtcccag agaggagtct cttaagtata
     3481 gctaagtgtc ttttacactt gtctgtctgt ctgtttttca aaaaaaggtt tctctgtgta
     3541 cctgtcctat ctgtcctgga actcactctg tagaacaggc tggcctcaaa ctcagagatc
     3601 cacctgcctc tgtcttctga atggtgggaa taaaggcctg cacaccacca cccagcagtg
     3661 tcatttcctc tcagggccca gcagtcatga agctatttct cagtcagtca tctgttccgt
     3721 tccttccctc ctcttcctcc ttccttcctt ccctcccttc ctctttcctt ccttccttcc
     3781 ttccctccct ccctccctcc ctccttcctt ccttccttcc ttccttcctt ccgtcctctt
     3841 gcctagcatc taagattcaa aagagacaac ccccatagac agctgctata ctggcaatgg
     3901 ggtcttaaaa ctgataatca gaaaacaagc aagagcttct tggaaggaac tggagtgtta
     3961 gggaacacag acctgggaag agaggagccc tgctgcagct gctgctgctg caatcccaac
     4021 atgtgagagg ctgaaacagg aaggctgtcc atttgaggtt aagttgtgat acacagcaag
     4081 tcaagagcct ctctctgctt ctgcctctct ccctctttgt gtatctgtct gtttcttgtg
     4141 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt tgattggttt
     4201 tggacttttt ccccttgggg agactccaat accgatttct gtggtgatta cacacacatt
     4261 cccagtagca atgtagaaga acgttttcag ctatgctcac gcctttaatc acagcactca
     4321 ggaggcagaa gaaagcagat gtctgagttt gagccagcct ggtctacaga gtgagtaaat
     4381 tccaggatac ccagggctat caaacaaaca tttcttgtca ctcagggtct tggtgacagt
     4441 catttctcct ggggtgagat ggcatttcaa tgtatttttc aatttgcatt tccattgtgg
     4501 ccaggtgtgt tgaatatttt ttccaatatc tattaacaat tcttttttta ttattattaa
     4561 atttacttaa tttctatttt ttattcattt attatatata agtacactgt agctgtcttc
     4621 acatacacca gaagagggta acagatctct ttacagatgg ctgtgagcca ccatgtggtt
     4681 gctgggaatt gaactcagga cctctggaag agcagtcggg tctcttaacc actgagccgt
     4741 ctctccagcc cctattaaca attcttatct cttcttttgg gaagtatctg accaattcat
     4801 ttgtccatgt attgaccaac gatctggtat tgggaattta aatactggag ttccttgtat
     4861 aatatacata attccattag ataatttttt ttttggttct ttttttcgga gctggggacc
     4921 gaacccaggg ccttgcactt cctaggcaag cgctctacca ctgagctaaa tccccaaccc
     4981 cctccattag ataattaact ggtcaaattt tctcccattc tgattgcccc acacacatgt
     5041 agagacgaaa ggttgaactc tccgtggttg tcagtttgcc ttgtcttgtt ttgttttgga
     5101 gacagaattt cactagttct gactggcctg aaacttgcta ggtaaaccag gctggcctca
     5161 aactcaccga gatatccccc tgcctctgcc tcctaagtgc tgagactaag acaagtgcta
     5221 ccatgcccat ccaccctact ttttctttta ttaaatattt gcttattttc ttgtg
//
LOCUS       NM_001436659            1047 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated 4 (Spata4), transcript
            variant 1, mRNA.
ACCESSION   NM_001436659 XM_006253095
VERSION     NM_001436659.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Liu,S.F., He,S., Liu,B.W., Zhao,Y. and Wang,Z.
  TITLE     Cloning and characterization of testis-specific spermatogenesis
            associated gene homologous to human SPATA4 in rat
  JOURNAL   Biol Pharm Bull 27 (11), 1867-1870 (2004)
   PUBMED   15516739
  REMARK    GeneRIF: expressed specifically in the testis only; expression
            occurs in a development stage-dependent pattern; cloned
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006253095.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2204439.1,
                                           SRR26360186.2083499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000016.1  43955989-43956211   c
            224-353             JAXUCZ010000016.1  43955091-43955220   c
            354-472             JAXUCZ010000016.1  43954509-43954627   c
            473-693             JAXUCZ010000016.1  43954179-43954399   c
            694-810             JAXUCZ010000016.1  43950649-43950765   c
            811-1047            JAXUCZ010000016.1  43946879-43947115   c
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1047
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
     exon            1..223
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..959
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis related gene 2; spermatogenesis-associated
                     protein 4"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4 isoform 1"
                     /protein_id="NP_001423588.1"
                     /db_xref="GeneID:306441"
                     /db_xref="RGD:1303065"
                     /translation="MAAAGRAEESLPLPAAESSKTTLPTPPAVPAARKPKKCLVYPHP
                     PRSSRLCPSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTS
                     LKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQ
                     DDFANFTDYSYQMRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQML
                     QRKLSRKLNPGWFDIKPTVGEITVGHLPAHSYKHKYKSKVSKERAVSSLSKSGNDVQP
                     HREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSCH"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     misc_feature    168..440
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /note="CH-like domain in sperm protein; Region: CH_2;
                     pfam06294"
                     /db_xref="CDD:461871"
     exon            224..353
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..472
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..693
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..810
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1047
                     /gene="Spata4"
                     /gene_synonym="Srg2; Tsarg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcatcat ggctgccgcc ggccgggcag aggagagttt accactgccg gcggcagaat
       61 catccaagac aaccttacct acaccaccag cagttcccgc cgcaaggaag cctaagaaat
      121 gtctggtgta tccacatccc ccgaggagct cccgcctgtg tccttccgtc ctgcgctggc
      181 tgcagggcct ggatctcagc ttcttcccga ggaatgttac cagggatttt tcaaatggct
      241 acctagttgc agagatattc tgtatatatt acccctggga ccttcgatta tcatcctttg
      301 aaaatggtac ttccttgaaa gtcaaattgg ataactgggc acaaatagag aagtttctag
      361 cgaaaaaaaa atttaaacta cctaaagaac tcatccatgg aacaattcac tgtaaggctg
      421 gggtgcctga aatactgatt caggagattt acactttact cacccatcaa gaaattagaa
      481 gcatccagga tgattttgct aatttcacag actatagtta tcagatgcgt ttgcccctgg
      541 ttcccaggag tacagtatca aagtctatta aaaataacat taggttatcg gaactactaa
      601 gcaatcctaa tattctcagc aatgaactca agatagaatt cctcttcctt ttgcaaatgc
      661 tgcaaagaaa attaagcaga aaattgaatc cagggtggtt tgatatcaaa ccaacagtgg
      721 gagaaatcac agttggccat cttcctgccc atagctataa gcacaaatac aaatcaaaag
      781 tttcaaagga aagagctgtg tcgtctttat caaaatcagg caatgatgtc caaccacata
      841 gagaaatcca tgtgaagcaa aatggaaaac cttgtgatgc cactgcaaaa cctatgataa
      901 atgtggaaga aacaatgaaa gacacggagg aagtagcttt gaagaagtca tgtcattaat
      961 gtctaccaca atctgggtat ataatgacac acccagtctt ggatgtattt aaataataaa
     1021 taacttaact tggtgtctta accataa
//
LOCUS       NM_001436715            2323 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1-like (Mtfr1l),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001436715
VERSION     NM_001436715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.16348.1,
                                           SRR26643298.29498.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on manual assertion,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  152030424-152030475 c
            53-178              JAXUCZ010000005.1  152027744-152027869 c
            179-283             JAXUCZ010000005.1  152027268-152027372 c
            284-393             JAXUCZ010000005.1  152025746-152025855 c
            394-605             JAXUCZ010000005.1  152025303-152025514 c
            606-927             JAXUCZ010000005.1  152024076-152024397 c
            928-2323            JAXUCZ010000005.1  152020175-152021570 c
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2323
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="mitochondrial fission regulator 1-like"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
     exon            1..52
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            53..178
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    89..91
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="upstream in-frame stop codon"
     CDS             164..1033
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM54B; family with sequence similarity 54, member
                     B"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1-like isoform
                     a"
                     /protein_id="NP_001423644.1"
                     /db_xref="GeneID:298549"
                     /db_xref="RGD:1305453"
                     /translation="MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPN
                     ISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVP
                     NLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSSG
                     SSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPTIPLLCSASPECCKSEHKTT
                     CSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRK
                     FALKEEDISRKGN"
     misc_feature    182..913
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    182..913
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Mitochondrial fission regulator; Region:
                     Mito_fiss_reg; pfam05308"
                     /db_xref="CDD:461620"
     misc_feature    242..244
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    275..277
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    461..463
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    482..484
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    824..826
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9CWE0; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    866..868
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    935..937
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     misc_feature    971..973
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H019; propagated from
                     UniProtKB/Swiss-Prot (Q5XII9.1); phosphorylation site"
     exon            179..283
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            284..393
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            394..605
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            606..927
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
     exon            928..2323
                     /gene="Mtfr1l"
                     /gene_synonym="Fam54b; RGD1305453"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgagg acgtttgagg cttggccgcc cactgtggta ggaggggctg aggaaaggaa
       61 gtctcatgct ccgggaaatg gcctgatatg aaggagtcac acctccagcc ttccctgtgg
      121 gtgccttgtc ctttgggtgc aggagctggc tgaaacatca ggaatggaag ccaatgtgac
      181 tatcccaatc tggcagaaca agccacatgg ggctgctcgc agtgtggtaa gaagaattgg
      241 gaccaatctg cccctgaaac cttgtccacg ggcatccttt gagaccctgc ccaacatctc
      301 tgacctgtgt ttgaaagatg tgcctccagt cccgactctg gctgacatcg cctggattgc
      361 cgcagatgaa gaggagacat atgctcgggt caggagcgat acacgccctc tgagacatac
      421 ctggaagccc agccctctga ttgtcatgca acggaatgcc tcagtgccca atctgcgtgg
      481 gtctgaggag aggctcctgg ccctgaagaa gccagccctg cctgccctaa gccgcaccac
      541 tgagctgcag gatgaactaa gccacctgcg cagccagatt gctaaaatag tggcagcaga
      601 tgcagcttcg gcctcattaa cgccagattt cttatcttca ggaagttcaa atgtctcctc
      661 tcctttgcct tgctttggat cctcattcca ctctacaact tcctttgtca ttagtgacat
      721 cactgaggag actgaggttg aggtccccga gcttccaaca atccccctgc tttgttctgc
      781 cagccctgaa tgttgcaaat cagaacacaa aactacctgc agctcgtctg aagaggatga
      841 ctgcatctct ctgtccaagg ccagcagctt tgcagacatg atgggcatcc tgaaggattt
      901 tcatcggata aaacagagcc aagacctgag ccggagttta ctgaaggaag aagaccctgc
      961 tgtccttatc tctgaggtcc ttaggaggaa gtttgccctg aaggaagaag acatcagtag
     1021 aaaaggaaac tgacagcact gactgcaaac tcttctcttg ctcctgaact ccttcaatag
     1081 ctgccttcct cactgcagat gtctgtctca gttgagatct gaacagtctt gctgactagg
     1141 gcttgggctg gaagagaaga gctggattat ttgttacctg cacttaaacc ctggcagagt
     1201 ctaaggtcta tggtttttgg agatgtgaca tttgttacag gtaattgggt agagtggagt
     1261 atctctgctt aaggcgtgaa gtttgttttt tcttgtctct gaaaaataag ccctctatga
     1321 atgacttaat taactcactg cattagactc cataattggt ctcactggac atgttgtgca
     1381 cagcagtcac tctcggcagc ttccctgcag caccacaggg ctgaggggga gcggctgtta
     1441 gttcatgctc acaggaaggt cttctgctgc ttcatcacag acatacacca gtgcccacag
     1501 tcaccctttc cctctagctg cagagggcag gccactgggc cagccaatat ctgggctgct
     1561 gcagggaggc ctggcctgtt ttttcttaaa cattttataa aactacaacc tgatctaccc
     1621 tccagggcct cattagttcc actgattgaa tttttttttc ttccatggac ttactaagtc
     1681 catcttggaa ggagaaatgt ggagacaaaa agagcatacc atccttctag gacagtgact
     1741 gatctctcta ggttgggtca agattttatt tactgcatca tgcatgactc aggtgccctc
     1801 agggcccttt tctctatggt atgaatactg tgtgttttga gttgaagcat tacctgatat
     1861 taaatgaagg atttggagaa atggtgtagt ttttctttat tctgtctctg aattttgacc
     1921 acagtggcct ctggtgaaga gagggctcct gttgattcta aggtatgtga acttttaaaa
     1981 aacaggctcc tgacttcctt tcttgccctc aggacagtgg tgctcactgt gaccctttaa
     2041 tacaagtcct tatgctatgg tgaccccctc tccccacatc cataaaattt tgttgctact
     2101 tcataactaa atttgctacc attaagagtt gtaatatggg ctgtatagac ggctcagtgg
     2161 ttgggagcac tgactgttct ttccggaggt tctgagttca aatcccagca atgacatcgt
     2221 ggctcaaaac catctgtaat gagatccgat gccctcttct ggtgtgtctg aagacagcta
     2281 cagtgtactt acatataata aataaataaa tcttaaaaaa aaa
//
LOCUS       NM_001107221            1336 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus C1q and TNF related 7 (C1qtnf7), transcript
            variant 1, mRNA.
ACCESSION   NM_001107221 XM_001060132 XM_223507
VERSION     NM_001107221.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Bi,J., Duan,Y., Wang,M., He,C., Li,X., Zhang,X., Tao,Y., Du,Y. and
            Liu,H.
  TITLE     Deletion of large-conductance calcium-activated potassium channels
            promotes vascular remodelling through the CTRP7-mediated PI3K/Akt
            signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (12), 1-11 (2022)
   PUBMED   36514218
  REMARK    GeneRIF: Deletion of large-conductance calcium-activated potassium
            channels promotes vascular remodelling through the CTRP7-mediated
            PI3K/Akt signaling pathway.
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Rohrbach,S., Aurich,A.C., Li,L. and Niemann,B.
  TITLE     Age-associated loss in adiponectin-activation by caloric
            restriction: lack of compensation by enhanced inducibility of
            adiponectin paralogs CTRP2 and CTRP7
  JOURNAL   Mol Cell Endocrinol 277 (1-2), 26-34 (2007)
   PUBMED   17716811
  REMARK    GeneRIF: The purpose of the current study was to investigate
            age-dependent effects of caloric restriction on the release of
            adiponectin, expression and activation of adiponectin-related
            signaling and on parameters of altered insulin sensitivity.
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060132.1, XM_223507.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM031994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1336
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q and TNF related 7"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
     exon            1..61
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            62..307
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..939
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement C1q tumor necrosis factor-related
                     protein 7; C1q and tumor necrosis factor related protein
                     7; adiponectin g"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 7 isoform 1 precursor"
                     /protein_id="NP_001100691.1"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
                     /translation="MIVLLYVTSLAICASGQPRGNQAKGESYSPRYICSIPGLPGPPG
                     PPGANGSPGPHGRIGLPGRDGRDGRKGEKGEKGTAGLKGKTGPLGLAGEKGDQGETGK
                     KGPIGPEGEKGEVGPAGPPGPKGDRGDQGDPGLPGVCRCGSIVLKSAFSVGITTSYPE
                     ERLPIIFNKVLFNEGEHYNPATGKFICAFPGIYYFSYDITLANKHLAIGLVHNGQYRI
                     RTFDANTGNHDVASGSTVIYLQPEDEVWLEIFFNDQNGLFSDPGWADSLFSGFLLYVD
                     TDYLDSISEDDEL"
     sig_peptide     70..117
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <235..>480
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <235..>480
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    514..888
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     misc_feature    514..888
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     exon            308..1336
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaagatc ctgacttttg tacactggga atcctgcagc aacctaccct cccagagcac
       61 gagcccaaga tgattgtcct gctctacgtg acaagtcttg ccatctgtgc aagtggacaa
      121 cctcggggca atcaggctaa gggggagagc tactctccaa ggtacatctg cagcatccct
      181 ggcttacctg ggcccccagg tcctcctgga gcaaatggct cccctggacc ccatggtcgc
      241 attggccttc ctggaaggga tggtagagat ggcagaaaag gagagaaggg ggaaaagggc
      301 actgcaggtc taaaaggtaa gactggaccc ctgggccttg ctggtgagaa aggagaccaa
      361 ggagagactg ggaagaaagg acccatagga ccagagggtg agaaaggaga agttggtcca
      421 gctgggcctc ctgggccaaa gggagaccga ggagatcaag gggacccagg actgcctgga
      481 gtgtgcagat gtggaagcat cgtgctcaaa tctgcctttt cagttggcat cacaaccagc
      541 tacccagaag aaagactacc catcatattt aacaaagtcc tcttcaatga gggggagcac
      601 tacaaccctg caacagggaa gttcatttgt gctttcccag ggatctatta tttttcttat
      661 gatatcacgt tggccaataa gcacctagcc atcgggctgg tgcacaatgg gcagtaccgg
      721 ataaggacct ttgatgccaa cacagggaac cacgatgtgg cttcagggtc cacagtcatc
      781 tacctgcagc cagaagatga ggtctggctg gagattttct tcaatgacca gaatggcctc
      841 ttctcagatc caggctgggc agacagcttg ttctccgggt ttctcctcta tgttgataca
      901 gattacctgg attctatatc agaagacgat gagttgtgat ccggactgca ggcctgaatg
      961 ttgcaacatg agttccacag tggcttacac tctgatctaa tctggagtgc tggaaggtgg
     1021 agcaagtgat actgggattc agaacacatt ttttttacag atggctctgg cagagttaac
     1081 aaaataagac aaaccaccaa ccagttgaaa tcacaccaaa atgaacggca tgcaataacc
     1141 ccagacatgg accccctgaa gtaaagatcc taaatattta agcaaattaa gatgatgtta
     1201 acaaatttga atgcccttgg caatacaacc agcgggtagt gacactgcct cattaaatat
     1261 tcataaaact ccagttgtgt ttgttattta gaatagtcat aacattttag tggaatttgt
     1321 tgacaattct caggag
//
LOCUS       NM_001436688            1983 bp    mRNA    linear   ROD 21-MAR-2025
DEFINITION  Rattus norvegicus oxidoreductase NAD-binding domain containing 1
            (Oxnad1), transcript variant 4, mRNA.
ACCESSION   NM_001436688 XM_006252623
VERSION     NM_001436688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 19, 2025 this sequence version replaced XM_006252623.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.47352.1,
                                           SRR26643291.37712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000016.1  7300191-7300434
            245-379             JAXUCZ010000016.1  7305050-7305184
            380-443             JAXUCZ010000016.1  7305489-7305552
            444-550             JAXUCZ010000016.1  7308347-7308453
            551-692             JAXUCZ010000016.1  7309595-7309736
            693-935             JAXUCZ010000016.1  7324014-7324256
            936-1044            JAXUCZ010000016.1  7326003-7326111
            1045-1983           JAXUCZ010000016.1  7327163-7328101
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1983
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="oxidoreductase NAD-binding domain containing 1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
     exon            1..244
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="upstream in-frame stop codon"
     exon            245..379
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1199
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="isoform 1 is encoded by transcript variant 4;
                     oxidoreductase NAD-binding domain-containing protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001423617.1"
                     /db_xref="GeneID:306270"
                     /db_xref="RGD:1311534"
                     /translation="MAHVLIPGLSRGSVGAICTQAASWALPTSTLRSLTLASVMRSRR
                     KTDHLERTATVLRREVMAAAKVCEITHESPSVKSLRLLVADKDFSFKAGQWVDFFIPG
                     VSVVGGFSICSSPQQLERERIIELAVKYTNHPPAVWVHNKCTLDSEVALRVGGEFFFD
                     PQPTDAPRNLVLIAGGVGINPLLSILRHSADLHRDHKEKRRGYDIGTIKLFYSAKNTS
                     ELLFKKNILDLVHEFPEKIACSFHVTKQTTQISSELKPYVTDGRITEKEIREHISAET
                     LFYVCGPPPMTDFFSKHLESSHVPKEHICFEKWW"
     misc_feature    468..1187
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    468..1187
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; Region: FNR_like;
                     cd00322"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674,795..797)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(549..551,585..596,645..653,663..674,795..797)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(585..587,591..596)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="conserved FAD binding motif [chemical binding];
                     other site"
                     /db_xref="CDD:99778"
     misc_feature    order(663..665,672..674,681..683,702..704)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(663..665,672..674,681..683,702..704)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(780..782,792..803,807..809)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(780..782,792..803,807..809)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(795..800,903..911,1110..1115)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     misc_feature    order(795..800,903..911,1110..1115)
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99778"
     exon            380..443
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            551..692
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            693..935
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1044
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1983
                     /gene="Oxnad1"
                     /gene_synonym="RGD1311534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgggc ttgggatata aacgagtgtt ttatgctggt ggtgtcgtgt cctccatcgc
       61 tgacttcaga gaacatttaa agagttgata gaggctactc cctcttaaga gggggtcagt
      121 gagactcagg gagccacaca gcgtcctctc cagtcctcct cgacacacag cgctcctgca
      181 gtagcgtttc aggcgacctt gagctctgag tgacgcctgg cctgttatga gttcctgcct
      241 gcagttccat ttgcccaggc agcaccatgg cccatgtctt gattcctggg ttgtctcgag
      301 gctctgtggg agccatctgc actcaggctg cttcgtgggc actgcctacc agcactctgc
      361 gttcccttac cttagccagc gtaatgagat ccagaaggaa aactgaccac ctagagagaa
      421 ccgccactgt cctccgccgg gaggtcatgg ctgcagctaa ggtgtgtgag atcactcacg
      481 agtctccatc agtgaagagc ctccgtttgc ttgttgctga taaagacttt tccttcaagg
      541 ctggccagtg ggttgatttc ttcatcccag gagtttcagt ggttggtggg ttttcaattt
      601 gctccagtcc ccaacagcta gaacgagaga gaataataga attggcagtg aaatacacga
      661 accatcctcc tgctgtctgg gttcacaata agtgcacact tgactcagaa gtggctctca
      721 gagtaggtgg agagttcttc tttgaccctc agcccacaga tgcccctcga aacctcgtct
      781 tgattgctgg aggggttggg attaaccccc tgctttctat cctgcgccac tcggcagatc
      841 tccaccggga ccacaaagaa aaaaggagag gctatgatat aggaacaata aaactgttct
      901 acagcgcaaa gaacaccagt gaactcctgt ttaagaaaaa tatcctcgac ttagtacatg
      961 agtttcctga gaagattgcc tgcagttttc acgttacaaa acagacgacc caaatcagtt
     1021 ctgaacttaa gccttatgtc acagatggaa gaataacaga gaaggagata agagagcaca
     1081 tttcggcaga gactctgttc tatgtctgcg gcccacctcc aatgacagac tttttctcta
     1141 agcatctgga aagcagccac gttcccaagg aacacatctg ctttgagaag tggtggtagg
     1201 agcaggcaca gaagacctga gagccgctca ggacagtgag aaccagcaac agagtcacac
     1261 gagaaacttc ccgcagactt cattggtggc actatttttc actatattga tttttctttc
     1321 attaattatc ctatgatagt tcattattac agaatttctg acctttgggg aaaagaccat
     1381 gctcaaccca attgtaatta aaagatttac tgatgagctg ctggcaggaa gacaggctga
     1441 gagccagatt tgagatggcc ataaataaaa gagggtgggg ggaaaggttt cccaaaggga
     1501 aaaccatggg gaggctcacg gtatctatgc aagcaggcag actctggcct gttctgccaa
     1561 gattaagtgg gtaaagcaac tggaaacaat ctgggtgtct gcacacgcaa gttacagaag
     1621 ctgaaaacgg cctccatagc caggagaagc tcacagctgt gcgtttctgg ggacccctga
     1681 gccagggctg ttttctggga ccccgtcttt ctggaatttt gagtctatgg cgagcagtca
     1741 tcagtactaa gatggaggga ggcctagaaa aaaatagttt ctcgagttgg cctttacacc
     1801 acgaactgat taatacaggt ttttcttttg ccctttgggg gcaaattagt ctaattatgt
     1861 taattaaagg aaagtgtggg ttttgtgtga actgtatact tctctaaata attggacaga
     1921 aattcataaa atttatgttt actgaattta taattttaaa tacattcttt attttgaaat
     1981 gtc
//
LOCUS       NM_001436722            2842 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22),
            transcript variant 1, mRNA.
ACCESSION   NM_001436722 XM_063275358
VERSION     NM_001436722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_063275358.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1619976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663602, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000016.1  8480038-8480302
            266-425             JAXUCZ010000016.1  8482820-8482979
            426-625             JAXUCZ010000016.1  8535616-8535815
            626-713             JAXUCZ010000016.1  8564932-8565019
            714-842             JAXUCZ010000016.1  8611088-8611216
            843-1050            JAXUCZ010000016.1  8626516-8626723
            1051-1183           JAXUCZ010000016.1  8630072-8630204
            1184-1257           JAXUCZ010000016.1  8630924-8630997
            1258-1379           JAXUCZ010000016.1  8631987-8632108
            1380-2265           JAXUCZ010000016.1  8634177-8635062
            2266-2842           JAXUCZ010000016.1  8637247-8637823
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2842
                     /gene="Arhgap22"
                     /note="Rho GTPase activating protein 22"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
     exon            1..265
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            266..425
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    284..286
                     /gene="Arhgap22"
                     /note="upstream in-frame stop codon"
     CDS             374..2494
                     /gene="Arhgap22"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 22"
                     /codon_start=1
                     /product="rho GTPase-activating protein 22 isoform 1"
                     /protein_id="NP_001423651.1"
                     /db_xref="GeneID:306279"
                     /db_xref="RGD:1307237"
                     /translation="MLPAASSKRRTFASRYFTRSKSLVMGEQSRSPGRPLAPHKLGPV
                     LKAGWLRKQKSIMKNWQQRWFVLRGDQLFYYKDKDEGKPQGFISLQGTQVTELLPDPD
                     DPGKHLFEITPGGAAEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFG
                     QRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDC
                     GEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELA
                     KQVSNLPQANYNLLRYICRFLDEVQAHSDVNKMSVQNLATVFGPNILRPQVEDPVTIM
                     EGTSLVQHLMTVLIRKHGQLFATPSFEEPASPRGTVQGTVEWGSEEVTRDHQGEPGSS
                     GLPTHRTSSLDGPAAAVLSRTSPPRLGSQAGPAATSPGKRMHTLPGWKSSFRQQGSRS
                     ESPKGVSSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPP
                     SSHLSSTASVASTAWSVASSSREASIGSCTACRASNSSACSSLHTEWALEPSPLPSSS
                     EGHPSPDLGHSLDEACVGSGSSEPNDPGSPSQAHVRRCRALQGQVAELRAELCHQRIE
                     YQRSLKSIEEGNSDLRKQMCRLEEELDQEKKKYAMLEIKLRNSERAREDAERRNQLLQ
                     REMEEFFATLGSLTAGTKGARAPE"
     misc_feature    497..844
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    497..844
                     /gene="Arhgap22"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    842..1438
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    842..1438
                     /gene="Arhgap22"
                     /note="GTPase-activator protein (GAP) domain for Rho-like
                     GTPases found in ARHGAP22, 24 and 25-like proteins; longer
                     isoforms of these proteins contain an additional
                     N-terminal pleckstrin homology (PH) domain. ARHGAP25
                     (KIA0053) has been identified as a GAP for...; Region:
                     RhoGAP_ARHGAP22_24_25; cd04390"
                     /db_xref="CDD:239855"
     misc_feature    order(974..976,1085..1087,1097..1099,1310..1312,
                     1319..1324,1394..1396)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    order(974..976,1085..1087,1097..1099,1310..1312,
                     1319..1324,1394..1396)
                     /gene="Arhgap22"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239855"
     misc_feature    974..976
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    974..976
                     /gene="Arhgap22"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239855"
     misc_feature    <1487..>2434
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <1487..>2434
                     /gene="Arhgap22"
                     /note="Domain of unknown function (DUF4670); Region:
                     DUF4670; pfam15709"
                     /db_xref="CDD:464815"
     misc_feature    <2165..>2437
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <2165..>2437
                     /gene="Arhgap22"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            426..625
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            626..713
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            714..842
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1050
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1183
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1257
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1379
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..2265
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2842
                     /gene="Arhgap22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcatcat ccccagaggc atcgaggaga caggaaacct gcatcctgcc tgatgatgtt
       61 cagcctgggt tgcatcccct ggtcctacca gcgggctcga cccatgggag ccaggggcag
      121 ggccaaaggc agggcgccca cagggtgaga agaggggcgg cagcccaagt gctccctccg
      181 ggcgccgaag aaggagcccc cggaggctcg ggcaaaggca gagaagcctg ctctccaggt
      241 ccagatgagc agaggtgaaa cccagatgct gatcgcccgc tgctgaaacc gggaattagc
      301 tcgtctctct gaggatgtgg ctgctgcctt ccagagaaga tacaggagaa atctgcacgc
      361 tgccagctta gagatgctgc cggcggcttc cagcaaaaga agaaccttcg cctccagata
      421 cttcactcgc tccaagagcc tggtgatggg ggaacagagc cggagcccag ggaggcccct
      481 ggccccccac aagctgggcc ctgtactcaa agccggctgg ctgaggaagc agaagagcat
      541 catgaagaac tggcagcagc ggtggtttgt gctgcgtggg gatcagctct tctactacaa
      601 agacaaagat gagggcaagc cccagggatt tatttctcta caagggacac aagtgactga
      661 gcttcttcca gaccctgacg acccaggaaa gcacctgttt gagattacac caggcggtgc
      721 cgcagagcgg gagaaggtgc cagccaatcc tgaggcgctc ctgctcatgg ccagctccca
      781 gcgtgatatg gaggactggg tgcaggccat ccgccgagtc atctgggccc cgctgggcgg
      841 agggatcttt gggcagcgac tggaggacac agtgcaccat gagcggaagt ttggtccccg
      901 gctggcacct ctgctggtgg agcagtgtgt ggacttcatc cgggagcgag gactcagtga
      961 agaggggctc ttccgtatgc ccggccaggc caacctggtg agggacctgc aggattcctt
     1021 cgactgtggg gagaagccgc tgtttgacag caccacagac gtgcacacag tggcctcctt
     1081 gctgaagctc taccttcggg agctcccgga gccggtcatc cctttcgcca ggtatgagga
     1141 cttcctcagc tgcgcccagc tgctcaccaa ggacgagggg gaggggaccg tggagttggc
     1201 gaaacaagtg agcaaccttc ctcaggccaa ctacaacctg ctcagataca tctgcaggtt
     1261 tctggatgaa gtgcaggccc actcagacgt caacaagatg agcgtccaga acttggcaac
     1321 tgtctttggc cctaacatcc tccggccaca ggtggaggat ccagtcacca tcatggaagg
     1381 cacatctttg gttcagcatc tgatgactgt cctcatccga aaacacggac agctctttgc
     1441 cacgccctcc tttgaagaac ctgcttcacc acgtggtact gtccagggca cagtagagtg
     1501 gggctctgaa gaggtcacca gagaccacca gggcgagcct gggagctctg gcttgcccac
     1561 acacaggact tcctctctgg atgggccagc tgcagcagtg ctctctagaa cttctccgcc
     1621 acgccttggc agccaagccg gccctgcggc caccagccct gggaagagga tgcatacttt
     1681 gcctggctgg aagtcttctt ttcggcagca ggggtcccgg tcagagagcc caaagggggt
     1741 cagctcatcc ttagaggtac ccatcatctc ctctggtggg aactggctca taaacgggct
     1801 atcgtctctt cgcagccacc gtcgggcctc atcaggggac cggcttaagg atacaggctc
     1861 agcacagaga ctctccacct atgataacgt gccaccatcc agccaccttt ctagcactgc
     1921 cagcgtggcc agcacggcat ggtctgtagc ctcatcctcc cgagaggcct ccatcggcag
     1981 ctgcactgcc tgccgggcca gcaactcttc tgcctgcagc tccttacaca ctgagtgggc
     2041 actcgagccc tctcctctcc ccagcagcag tgagggccac ccgtccccgg acctgggcca
     2101 cagcttggat gaggcatgtg tgggcagtgg cagcagtgag cccaatgacc cgggcagtcc
     2161 ctcacaggcc catgttcgcc gctgccgggc tctccagggc caggtggccg agctcagggc
     2221 ggagctgtgt caccagagga ttgagtacca gaggagcctg aaaagcatcg aggagggcaa
     2281 ttctgacctg cggaagcaga tgtgtcggtt ggaagaggag ctggaccagg agaagaagaa
     2341 gtatgccatg ctggagatca agcttcggaa ctccgagcga gcacgtgagg acgcagagcg
     2401 caggaaccag ttgctgcaga gggagatgga ggagttcttc gccaccctgg gaagcttgac
     2461 tgctgggacc aaaggggcca gagccccaga gtgaaaggag cggaagcgca tgtccaccta
     2521 tgtccactca ctttccctgc agggctggcc acaggctgca gaggaagccg ggagcttcaa
     2581 gtttgggcca ggccaccagc agggtcatct gcctccaagt gccagataga gaggggcctg
     2641 acgccagaat gggtactgtc aggatcccac atagtccagg caggatctgg atacttctcc
     2701 acacatacgg gtcccaggag gtgtcagggg cgatggtgcc aagatcatga gcatcagcct
     2761 ctcctccagg aagagtcagt ccccagtggc cacctggaga gccaggccac cgccaagaac
     2821 tattaaatgt gctctgaaag ca
//
LOCUS       NM_001436741            3306 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus transketolase (Tkt), transcript variant 1, mRNA.
ACCESSION   NM_001436741 XM_006252661
VERSION     NM_001436741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Zhao,Y., Wu,Y., Hu,H., Cai,J., Ning,M., Ni,X. and Zhong,C.
  TITLE     Downregulation of transketolase activity is related to inhibition
            of hippocampal progenitor cell proliferation induced by thiamine
            deficiency
  JOURNAL   Biomed Res Int 2014, 572915 (2014)
   PUBMED   25028661
  REMARK    GeneRIF: results suggest that modulation of transketolase activity
            might be one of the mechanisms by which thiamine regulates the
            proliferation of hippocampal progenitor cells.
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Mitschke,L., Parthier,C., Schroder-Tittmann,K., Coy,J., Ludtke,S.
            and Tittmann,K.
  TITLE     The crystal structure of human transketolase and new insights into
            its mode of action
  JOURNAL   J Biol Chem 285 (41), 31559-31570 (2010)
   PUBMED   20667822
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Wang,J.J., Martin,P.R. and Singleton,C.K.
  TITLE     Aspartate 155 of human transketolase is essential for thiamine
            diphosphate-magnesium binding, and cofactor binding is required for
            dimer formation
  JOURNAL   Biochim Biophys Acta 1341 (2), 165-172 (1997)
   PUBMED   9357955
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   McCool,B.A., Plonk,S.G., Martin,P.R. and Singleton,C.K.
  TITLE     Cloning of human transketolase cDNAs and comparison of the
            nucleotide sequence of the coding region in Wernicke-Korsakoff and
            non-Wernicke-Korsakoff individuals
  JOURNAL   J Biol Chem 268 (2), 1397-1404 (1993)
   PUBMED   8419340
REFERENCE   8  (bases 1 to 3306)
  AUTHORS   Abedinia,M., Layfield,R., Jones,S.M., Nixon,P.F. and Mattick,J.S.
  TITLE     Nucleotide and predicted amino acid sequence of a cDNA clone
            encoding part of human transketolase
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1159-1166 (1992)
   PUBMED   1567394
REFERENCE   9  (bases 1 to 3306)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   10 (bases 1 to 3306)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006252661.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55230.1,
                                           SRR22399484.1527130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000016.1  5730875-5731064
            191-308             JAXUCZ010000016.1  5740422-5740539
            309-422             JAXUCZ010000016.1  5741405-5741518
            423-520             JAXUCZ010000016.1  5742133-5742230
            521-712             JAXUCZ010000016.1  5747104-5747295
            713-831             JAXUCZ010000016.1  5748625-5748743
            832-1025            JAXUCZ010000016.1  5749659-5749852
            1026-1190           JAXUCZ010000016.1  5750484-5750648
            1191-1347           JAXUCZ010000016.1  5751274-5751430
            1348-1478           JAXUCZ010000016.1  5751544-5751674
            1479-1562           JAXUCZ010000016.1  5752336-5752419
            1563-1656           JAXUCZ010000016.1  5752527-5752620
            1657-1779           JAXUCZ010000016.1  5753474-5753596
            1780-3306           JAXUCZ010000016.1  5754882-5756408
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3306
                     /gene="Tkt"
                     /note="transketolase"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
     exon            1..190
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Tkt"
                     /note="upstream in-frame stop codon"
     CDS             84..1955
                     /gene="Tkt"
                     /EC_number="2.2.1.1"
                     /note="isoform 1 is encoded by transcript variant 1; TK"
                     /codon_start=1
                     /product="transketolase isoform 1"
                     /protein_id="NP_001423670.1"
                     /db_xref="GeneID:64524"
                     /db_xref="RGD:621036"
                     /translation="MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSA
                     AEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRK
                     ISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSE
                     GSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDVYQKRCEAFGWHAIIVDG
                     HSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYS
                     QVQSKKKILATPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYGLALAKLGHASDR
                     IIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAF
                     FTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSD
                     GVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGA
                     GVTLHEALAAAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEG
                     GIGEAVSAAVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTKG"
     misc_feature    84..86
                     /gene="Tkt"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    99..101
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    105..1943
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    105..1943
                     /gene="Tkt"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    114..116
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    192..194
                     /gene="Tkt"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); other site"
     misc_feature    393..395
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    513..515
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    693..695
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    777..779
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40142; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    804..806
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    855..857
                     /gene="Tkt"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); other site"
     misc_feature    861..863
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    906..908
                     /gene="Tkt"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    942..944
                     /gene="Tkt"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    966..968
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    1116..1118
                     /gene="Tkt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); phosphorylation site"
     misc_feature    1695..1697
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40142; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     misc_feature    1890..1892
                     /gene="Tkt"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P29401; propagated from
                     UniProtKB/Swiss-Prot (P50137.1); acetylation site"
     exon            191..308
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            309..422
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            423..520
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            521..712
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            713..831
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1025
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1190
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1347
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1478
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1562
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1656
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1779
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..3306
                     /gene="Tkt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggtcact gccggtcgct tcctgagcct cctctggctc tgtgtctctg tcctcagctt
       61 ccacgtcctc gcccgaccgc gccatggagg gttaccataa gccagatcag cagaagctcc
      121 aggccctgaa ggacacagcc aatcgcctgc gcatcagctc catccaggcc accaccgcgg
      181 caggctcggg acaccccaca tcatgctgca gcgctgccga gatcatggct gtcctgtttt
      241 tccataccat gcgctacaag gccctggatc cccgaaaccc tcacaatgat cgctttgtgc
      301 tctccaaggg ccatgcagct cccatcttat atgcagtctg ggctgaagct ggcttcctgc
      361 ctgaggcaga gctgctgaac ctgaggaaaa tcagctctga cttggatggg catcctgtcc
      421 cgaaacaagc cttcaccgat gtggccactg gctccctggg ccaggggctg ggagctgcgt
      481 gcgggatggc atacacaggc aaatacttcg acaaagccag ctaccgagtc tattgcatgc
      541 tgggagacgg ggaggtgtcc gagggctccg tttgggaggc catggccttc gctggaattt
      601 acaagctgga caacctcgtt gccatttttg acatcaaccg tctgggccag agcgacccag
      661 ccccgctgca gcaccaagtg gacgtctacc agaagcgctg tgaggccttt ggctggcatg
      721 ccatcatcgt ggatgggcac agtgtggagg agctgtgcaa ggcctttggt caggccaagc
      781 accaaccaac agccatcatt gccaagacct tcaagggccg cgggatcaca gggattgaag
      841 acaaggaggc gtggcatggg aagcccctcc ccaaaaacat ggctgagcag attatccagg
      901 agatttacag ccaggttcag agcaaaaaga agatcctcgc cacgccccct caggaggatg
      961 ccccttccgt ggacattgcc aacatccgaa tgcctacccc acccaactac aaagtggggg
     1021 acaagatagc cacacggaaa gcctatggat tggcccttgc caagctgggc cacgccagtg
     1081 accgcatcat cgccctggat ggagacacca aaaattccac cttctcagag ctcttcaaaa
     1141 aggagcaccc agaccgtttc atcgagtgct acattgctga gcagaacatg gtgagcattg
     1201 ctgtgggctg tgccacacgt gacaggacag tgcccttctg cagcactttt gcggccttct
     1261 tcacacgcgc cttcgaccag atccgcatgg ccgccatctc cgagagcaac atcaacctct
     1321 gtggctccca ttgcggcgtg tccattgggg aagacgggcc ctcgcagatg gccctggaag
     1381 acctggccat gtttcggtcg gtccctatgt ccaccgtctt ttacccaagt gatggagttg
     1441 ccacagagaa ggcagtggaa ttagcagcca atacaaaggg catctgcttc attcggacca
     1501 gccgcccaga aaatgccatt atctatagca acaacgagga tttccaggtt ggccaagcca
     1561 aggtggtcct gaagagcaag gacgaccaag tgacggtgat cggggctggc gtaactctgc
     1621 acgaggctct ggctgctgca gagatgttga agaaagagaa gatcggcgtc cgtgtactgg
     1681 accccttcac catcaagccc ctggacaaaa agctcattct cgactgtgcc agagcaacca
     1741 aaggcaggat cctcaccgtg gaggaccact actatgaagg tggcataggc gaggcagtat
     1801 ctgctgcggt agtgggcgaa cctggagtca cagtcactcg cctggcggtc agccaagtac
     1861 cacgaagtgg gaagccagct gagctgctga agatgtttgg tattgacaaa gacgccattg
     1921 tgcaagctgt gaagggcctt gtcaccaagg gctaggaagg acatgggatg ccgggtgggt
     1981 gaactacaca ttccagggat gttctggcaa aggtgctcaa gggtgtaccg agtggaaagg
     2041 taaatatatg ttttgagaaa aaaattaatc ctgactgttt tctttgatat gaacatatcc
     2101 agtataggaa gggagaaagg aagagagctg gctgtctaga cttggggggg tcaggatcta
     2161 aggtgtaccc tgggatcccc ttctccagtt cagcctctgc aaagccagaa ctactaccca
     2221 ctgtagcctg ccttttagcc agataggatc cagccccttt tctcaccact gtaccctaaa
     2281 ggactgtgga gttctccctg ccttataaaa ctttcctgat ccttcttagc cgcctcatgc
     2341 cccccaaggt cccgcaaggc ttccttttat aggtggccca ctggtaagct tcctaggaat
     2401 tcctcagtgt ccgtagggaa gatgaggccc atttgtggaa ctaggcacat gtctgctcct
     2461 tgaaaccgga gctgttcagc tggtgagctg cctggccaga tccttccgtg ccagggaact
     2521 gaatggtacc aactccagaa acagcagata aggtaggtct cagggagaag acggtgattc
     2581 ctcagtgggt ggtcttaggg caaaccctgg gagaaactct ccttcactga gaaaagaagg
     2641 caagtcatcg ccctgtgggg acagctgagg aacttcccag tcaagagttt ggagtttgga
     2701 cataattaca atgtattttc ttatgtagtc cataacaaca aaagggtaaa gcagaaaatc
     2761 agggattcgg ggtgcttggg caccacctgg tggccatctc tggtactaca gtgctaaaca
     2821 caccccacag caatctgtgg aaggtgctgt tttctgagat ctgggaagca actgctcgca
     2881 gaaggagatg gaggtgcccg tgacagtgct gaatgaactt cgtatgcatt ttatttgatc
     2941 cttactccaa gataccattt tagaagatat tcctcttggc ccagtgctga ggattggtct
     3001 gttgctttgt atcgtaacat caaatactgt acctgaaggt ctaaaagctt ttgttgtgca
     3061 aaccttcctt aatctaacac tattgtttaa ataaaaatga ctacagtcaa ttactggagg
     3121 gattagaggt aggccgcttt tgagtttcct ggttgggggt tgcggaggga ggagaggtga
     3181 gagaaggaag ccaccacagg aggaggtgac catgaacaag tattgggtac tctgccgggg
     3241 aagtagcaag tccagcagac aggaaagtag attagggatt acctccagta attgtcaata
     3301 aaacaa
//
LOCUS       NM_001436763            6891 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus caspase 8 associated protein 2 (Casp8ap2),
            transcript variant 1, mRNA.
ACCESSION   NM_001436763 XM_006237974
VERSION     NM_001436763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6891)
  AUTHORS   Wu,T.Y., Leng,Q. and Tian,L.Q.
  TITLE     The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy
  JOURNAL   Cytogenet Genome Res 161 (3-4), 132-142 (2021)
   PUBMED   33882492
  REMARK    GeneRIF: The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy.
REFERENCE   2  (bases 1 to 6891)
  AUTHORS   Li,K., Pan,J., Li,Q., Li,S., Li,K., Cheng,Y., Chai,L., Li,C.,
            Li,J., Fu,Z., Wang,D. and Bai,Y.
  TITLE     The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury
            in Myocardial Cells by Regulating Apoptosis and Autophagy
  JOURNAL   Heart Surg Forum 23 (6), E797-E802 (2020)
   PUBMED   33234216
  REMARK    GeneRIF: The MicroRNA-210/Casp8ap2 Pathway Alleviates
            Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis
            and Autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6891)
  AUTHORS   Li,T., Song,X., Zhang,J., Zhao,L., Shi,Y., Li,Z., Liu,J., Liu,N.,
            Yan,Y., Xiao,Y., Tian,X., Sun,W., Guan,Y. and Liu,B.
  TITLE     Protection of Human Umbilical Vein Endothelial Cells against
            Oxidative Stress by MicroRNA-210
  JOURNAL   Oxid Med Cell Longev 2017, 3565613 (2017)
   PUBMED   28367268
REFERENCE   4  (bases 1 to 6891)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   5  (bases 1 to 6891)
  AUTHORS   Kim,H.W., Mallick,F., Durrani,S., Ashraf,M., Jiang,S. and
            Haider,K.H.
  TITLE     Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2
            and their role in cytoprotection during ischemic preconditioning of
            stem cells
  JOURNAL   Antioxid Redox Signal 17 (8), 1053-1065 (2012)
   PUBMED   22482882
  REMARK    GeneRIF: The ischemic preconditioning (IPC) enhances stem cell
            survival via the combined participation of hypoxia responsive miRs
            miR-107 and miR-210 via their respective putative target genes
            Pdcd10 and Casp8ap2.
REFERENCE   6  (bases 1 to 6891)
  AUTHORS   Kim,H.W., Haider,H.K., Jiang,S. and Ashraf,M.
  TITLE     Ischemic preconditioning augments survival of stem cells via
            miR-210 expression by targeting caspase-8-associated protein 2
  JOURNAL   J Biol Chem 284 (48), 33161-33168 (2009)
   PUBMED   19721136
  REMARK    GeneRIF: Data identified FLICE-associated huge protein
            (FLASH)/caspase-8-associated protein-2 (Casp8ap2) in (PC)MSCs as
            the target gene of miR-210.
REFERENCE   7  (bases 1 to 6891)
  AUTHORS   Smith,A.J., Karpova,Y., D'Agostino,R. Jr., Willingham,M. and
            Kulik,G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6891)
  AUTHORS   Milovic-Holm,K., Krieghoff,E., Jensen,K., Will,H. and Hofmann,T.G.
  TITLE     FLASH links the CD95 signaling pathway to the cell nucleus and
            nuclear bodies
  JOURNAL   EMBO J 26 (2), 391-401 (2007)
   PUBMED   17245429
REFERENCE   9  (bases 1 to 6891)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J Biol Chem 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   10 (bases 1 to 6891)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006237974.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000005.1  51810971-51811251
            282-343             JAXUCZ010000005.1  51817157-51817218
            344-426             JAXUCZ010000005.1  51819117-51819199
            427-495             JAXUCZ010000005.1  51824615-51824683
            496-596             JAXUCZ010000005.1  51825356-51825456
            597-671             JAXUCZ010000005.1  51826025-51826099
            672-787             JAXUCZ010000005.1  51828889-51829004
            788-2982            JAXUCZ010000005.1  51833247-51835441
            2983-6103           JAXUCZ010000005.1  51837496-51840616
            6104-6203           JAXUCZ010000005.1  51843874-51843973
            6204-6289           JAXUCZ010000005.1  51844824-51844909
            6290-6891           JAXUCZ010000005.1  51848025-51848626
FEATURES             Location/Qualifiers
     source          1..6891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..6891
                     /gene="Casp8ap2"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
     exon            1..281
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..343
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..426
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    354..356
                     /gene="Casp8ap2"
                     /note="upstream in-frame stop codon"
     CDS             372..6260
                     /gene="Casp8ap2"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001423692.1"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
                     /translation="MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDST
                     ARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEYGKCQQQMKDLMKRFKEIQTQNL
                     NLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
                     KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTN
                     NVWSRSPYQVSEGNSNEDNRRGRNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAAS
                     RLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKETSRERPHTRVEPQND
                     KNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMK
                     YYGFNKYHPEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQW
                     ENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTANGKRQT
                     EQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLSPAKKQP
                     VCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSAT
                     SQPRTSIPENKVKEENRLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEV
                     EETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDINSCDISEGGKKKVVLSPKAA
                     AASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPS
                     PQKTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSM
                     ESSCTIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVD
                     ELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTVHVHKDNGRTVVK
                     LPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKH
                     VRKNYMKFKIKFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESN
                     LKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVKHENDSS
                     EGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKHQDQN
                     KTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQ
                     HACVKSERGFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELK
                     TPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNWSLLSSEKGPSLSSGLSLP
                     VHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGH
                     LSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTS
                     RSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGMVAEESLTPLPRT
                     GKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQTQVPDIYEFL
                     KDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTK
                     DPATETKSLELMDVTVLDIDHLEHSKPNLDQDAQITCTSLQHDAVDAFIDLTHDVSNE
                     SKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGKVNSSLECTVEETCIDLTSESAGSF
                     EVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKTKR
                     LSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIK
                     KKGEIIVSWTRNDDREILLECQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEK
                     SKCR"
     misc_feature    <579..797
                     /gene="Casp8ap2"
                     /note="Afadin- and alpha -actinin-Binding; Region: ADIP;
                     pfam11559"
                     /db_xref="CDD:463295"
     misc_feature    <579..797
                     /gene="Casp8ap2"
                     /note="Afadin- and alpha -actinin-Binding; Region: ADIP;
                     pfam11559"
                     /db_xref="CDD:463295"
     misc_feature    6057..6251
                     /gene="Casp8ap2"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     misc_feature    6057..6251
                     /gene="Casp8ap2"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     exon            427..495
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..596
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..671
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..787
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..2982
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..6103
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6104..6203
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6204..6289
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6290..6891
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacagcggc cgctgtgcgg ggctggccgg ccgggtaagt tcctgagggc ctgtcgcggg
       61 gctgctgggg agaggcagcg gggtgccgcc tgggatggct tgcgccgtgg gcgaagggtt
      121 gtgcctggct gggcctcaag gagccagctg ctgtcctcgg ggaccgccct ttggagagtc
      181 tcgaggggct ctggggcgag cacacggagc atcgcccggt ctacactgcg cccctcccct
      241 cccccacccg tgtctcctag gtccctactt ccgagctttt gaatgtgaag aaaccgaggc
      301 ttaagccctt gtgagacaaa gtctggctgt attgagagaa aagatggcac ctatgaaaag
      361 gatataggac catggcagca gatgatgaca atggtgatgg aacgggtttg tttgatgtct
      421 gtcctgcctc tcctcttaaa aataatgatg aaggctcatt ggacatatat gctgggttgg
      481 acagtactgt ttctgacagt actgctaggt cctgcgtgtc gttcagaaac tgtctggatt
      541 tgtatgaaga gatcctgact gaagaaggaa ctgcaaagga ggcaacatac agtgacttgc
      601 agatagaata tgggaaatgt cagcagcaaa tgaaagatct gatgaaaaga tttaaggaaa
      661 tacagacaca gaacttgaac ttaaaaaatg aaaaccagtc tcttaagaag aatatctcag
      721 cacttatcaa aactgccaga gtggagataa accgtaagga tgaagagata aatcatcttc
      781 accaaagatt gtctgagttt ccacattttc gaaataacca taaaactgca agaacaaaag
      841 attcacgatc caaatctccc catttggaca attgttcaaa gactgatcat ggagttaaaa
      901 gtgatgttca gaaagatata catcctaaca cttcacaacc aaacttggaa aaggaaggga
      961 aatcacattc tgaagcacag aattctttgc acttgtctac gggtattgag aaacattgta
     1021 caaacaatgt ctggtcacgt tctccttacc aggttagtga aggtaactca aatgaagata
     1081 atagaagagg aaggaatggc gtcagacata gccaaggtag cagaggaact gacagaacac
     1141 agaaagactt gaatagcagc tgtaatgatg gcgagccaag ggacaaagag gctgcttcca
     1201 gactacacgg aaaccctgag aaacatggaa gcagtgaagc aagggctgag aacaaaattt
     1261 cagagattaa aagtagcact ggtttgggaa ataaaagcga gcgcagtgcc tcttcttggg
     1321 aaaaagaaac ttccagagaa aggccacata ctcgagtgga acctcaaaat gacaaaaatc
     1381 tagagagaca aaatgaaaga ttacaaaata cacacagaaa agagcttcag tctcaggaca
     1441 aagcagaaag aaaaggtgat gtgaagttta aaccagcagg agaggagcag gggcatcggg
     1501 gaagagtgga ccgtgcatta cctcctcatt ccaagaatga catgaaatat tatggcttca
     1561 ataagtatca tccagaagag agaaggggaa gggaagatgg taaacgagac agaggcatga
     1621 gcagtcatgg ctttcaagat agaagatgtt catcttctct ttcaagcaac agaaatagca
     1681 aatacccaca ctccaaggaa gtcagtgttg cacaccagtg ggaaaataca cctttcaaag
     1741 cagaaagaca tagaactgag gacaggagga aaagagaacg agaaaacaaa gaagaaagta
     1801 gacatgtgaa aagtgacaaa aaatcacctc cagaacactt gcaaaggact cataaagaca
     1861 ctaagaaaag tactgctaat ggaaagagac agacggagca gaaacacggt aaaggtccag
     1921 tctctaccag cgagctttct aaagggacag acaatagaga gtgtacaatg aaagtggaga
     1981 atgggccaaa tgaagcaaag ggcaaggact taaagttaag cttcatggag aagctgaact
     2041 taactctttc tcctgctaaa aagcagcctg tttgtcaaga taacgagcat caaataattg
     2101 gtgttcccaa gcccagtggc gtgtgtgact cacagtcctt ggagaagact gaaacagtgg
     2161 catgtcttcc ttctgtcagt gaacaagata gagaggaacc caaatcagag ttaccagagc
     2221 caaaggaggc tctttcagca acatctcaac ccaggaccag cattccagaa aataaagtga
     2281 aggaagaaaa tagattgtta tttaaatctg ttgagaatac tgtgccttgt gaactgcttg
     2341 cttgtggcac ggaaatttcc ttcccagcac ctgtagaaat tgagcaagca agatgtttgg
     2401 tccaatcaat ggaagtggaa gagacatgtg ctggtgcaag ggcagctgct tctgtggtga
     2461 tgcgtgtatt accagaacat gcttctgaag acttcagcca agaattgggc accaaaagac
     2521 atgatgatat aaattcgtgt gatatttctg aaggtgggaa aaaaaaggtg gttctttcac
     2581 caaaagcagc agcagccagt gagagccatc tggagcctgt ggttgaagaa cctagcattt
     2641 caccagtaaa ctgttcggga gacaataatc ctaaacttga accttctctt gaagagagac
     2701 ctaaggttga gaataaatct tctcctttgg agccttgttt acctaaagag atgtttgtac
     2761 cttcaccaca gaagactgag ttgattgacc acaaaataga tactggagaa tcaaactcgg
     2821 tatatcaaga tgatgataac tcagttttga gtattgactt taataatttg agacctattc
     2881 cagaacccat cagccctctg aatagtccag tgagaccggt atccaaagtt cttagcatgg
     2941 agagctcatg tacaattcca ctgtatgata gcagccataa agatgagttt ccatccaatt
     3001 caactctttc taccttcaag agtcagtctg atctaaataa ggaaaatgaa aaaccagttc
     3061 ccaaattgga caaatgttca gaagcagaat cctgtaagaa tttgtctgta gatgaattag
     3121 aagaagggga aattagaagt gatgatgaag aatctgtagc acaaaagcgt ttggaaaaga
     3181 gtgcaagacc cagaacttct actgaagtgc cgccaggtaa aatcagccca ggaagcagga
     3241 ggagcactgt gcatgtgcat aaggataacg ggaggacagt tgtaaaactc cctcgggaca
     3301 gaatcacatg gagccaaaga tcaaatgaat ctagaccctc aaacaccgaa aggaaaagta
     3361 aaacaatgag catctccagc ttggaaaaaa tacttccgct tattcttgca ccctcctccg
     3421 tatgggaagt tatgcatatg ttacggttgc taggaaaaca tgtaaggaaa aattacatga
     3481 aattcaagat aaaattttca ttgacacaat ttcatagaat tattgaatcg gcaattttga
     3541 gtttcacatc actaattaga taccttgatt tgtctaagat ctgtaaatca gtaagtactt
     3601 tacagaagag tctttgtgac gttatagaat ctaaccttaa acaagtgaag aagaatggca
     3661 tagttgaccg tttatttgaa caacaacaaa cagatatgaa aaaaaaattg tggaagtttg
     3721 tggatgaaca acttgattat ttgtttgaaa aacttaaaaa aatcctacta aagttttgtg
     3781 attctgtaaa gcatgaaaat gacagtagtg aaggaaaact tggaaaaaaa tataaagaga
     3841 gagcccaaca ttcaaattgt cagaagaaga aaatggacaa caaagaaata cggagagaaa
     3901 aagtgctaaa atcagaaaat actgtgaatt ttaaatcttc actggggtgt gaaaaatttg
     3961 aagaaaaaca tcaagaccaa aataaaacca atactactac agtaaagcat gatgtgaaaa
     4021 gaacttttag cacttgcact gataataata caaagaactc tgaatgtaaa gagcagtttc
     4081 tgggaatgaa ctgcccgagt acccccaggc caggagaaac tgaaggcaat gtggaggagg
     4141 ggacaccggc ggcacagcac gcctgcgtta agtcagagcg gggctttgag atcctcaccg
     4201 agcagcaggc gtccagcctt acttttaact tagtgagtga cgcacagatg ggtgagatat
     4261 ttaaaagttt gctacaaggt tctgatctgt tggacacagg tggcactgaa aaagcggagt
     4321 gggaattaaa gactccagag aaacagctgc tagagagcct caagtgtgag tctgcaccag
     4381 cttgtacaac agaagagcta gtttcagagg cggcttctct ctgtccaaag gtgatcagtg
     4441 atgataattg gtctttatta tcatctgaaa agggcccatc tctatcttca gggctttcac
     4501 tgccagttca tcctgatgtg ttagatgaaa attgtatgtt tgaagtatct tctaaccttg
     4561 ctttaagtaa agataatgta tacagctcag aaaagagtaa gccctgcatt tcttccatac
     4621 tcttagaaga tcttgcggtc tctttaacag taccgtcacc tctgaagtca gatggccatt
     4681 tgagtttctt aaagcctgaa gttttgtcaa cttcaactcc tgaagaagtt attagtgcac
     4741 attttagtga ggatgctttg cttgaggaag aggatgcatc tgaacaggac attcacttag
     4801 ctctagagtc tgataactca agcagtaagt caagctgttc ctcatggaca agccggtctg
     4861 ttgcttcagg ctttcagtac caccctaatc ttcccatgca tgctgtcatt atggaaaagt
     4921 ccaatgatca tttcattgtg aaaatacggc gtgcaacacc atctacctcc cctggcctta
     4981 aacatggtat ggtagctgag gagtcgttga cacctttgcc tagaactgga aaagaagctg
     5041 atggggcagc agagaaagaa cctaccctgt ttcagagtac agttttaaac cctgtccaag
     5101 acttggaaaa ttccgacaaa agtattgata agagcaaacc aactcatgaa gatcagaact
     5161 ctatagtaca aacacaggtt ccagatatat acgaatttct taaagatgct tcaaataagg
     5221 tggttcattg tgatcaagtg gttgatgatt gcttcaagtt gcatcaagta tgggaaccaa
     5281 aagtttctga gagccttcaa gaattgcctt caatggaaaa aaatgcacac tctgttgatg
     5341 atcatcttcc taatacacac atagatctaa caaaagatcc agctactgag actaaaagct
     5401 tggagctaat ggatgtaaca gttttagata tcgatcactt ggaacattct aaacccaact
     5461 tagatcaaga tgcacagata acgtgtactt cgttacagca tgatgctgta gatgctttta
     5521 ttgatttgac acatgatgtt tcaaatgaga gtaaaaacga aagtaatgaa cctgtgttaa
     5581 ctgttgaagg tgtgggatgc caggtaatat gtatagatga cgataaccac aaagaaggaa
     5641 aagtggggaa ggtaaacagt tccttagaat gtactgttga ggaaacctgt attgacttga
     5701 cctcagagtc tgctggctcc tttgaagtaa agagacacac tttaaagtca gagcctccat
     5761 caaagtcgga ttgtttagag ttgcctgaga ctctggggaa tggtcacaag aagagaaaga
     5821 acagtcctgc tgtgagtcac tcttctcaga aaaagcaaag aaaggacatg gacttaagta
     5881 gtgaaaagac caagagactt agtcctaatt ctgatagaac tggtgatgct cacagaaagc
     5941 atggcagcaa gaagagggaa cctgcagtaa gtgacacatc cttgtcatca gaggtcaacc
     6001 cagaggtgaa gggctcaaca gcaccacttg ctacttttcc aggaagcctt tctgcaaaaa
     6061 atgttatcaa aaagaaagga gaaattatag tttcatggac aagaaatgac gacagggaaa
     6121 ttttactgga atgtcagaaa agaatgccgt ccctgaaaac atttacccac ttggctgtca
     6181 aactgaataa aaatccaaat caggtttcag agaggttcca gcaactgaaa aagctttttg
     6241 agaagtcaaa atgcaggtag tagtgggtcc atcgcaggat gctaatgcta tgagttgctg
     6301 gatttcatgg tgcctcactg ataattcttc tacaaagaag cttcgattcc tcgtgtttta
     6361 aatggggaac taggtggagg ttttgtctca gttttggtga ctagatgatc atctaccttt
     6421 tttttacttt cctggtcatt gtgcttggct tattcagatc aacagtctga ttcactttcc
     6481 tgttattggt cagaatattt atttttaatc attaaaagtt gttatcaaat gaaagaataa
     6541 aagcaacctc aatgtaatac tgaaacctta gttttgatat tggatgaaat aacttcttta
     6601 gattttaaaa aacaattttg tagcatttta aatgtaatga ctatttagtt cacctttcta
     6661 ttcatttttg tttttataat tgcctcattt tggaaaattg tgaaataatt taaatagtat
     6721 atttgtatat atgtataatt attgtaatgt aaaatactat gactgtatgt gtcttgagtg
     6781 tatgtatgca catgaatggc tttgctagcc aaagggtttt tttatctata taaaatattt
     6841 tgtataaact ttcctttcag ttagtcatgt ataataaaaa catgtaaagt c
//
LOCUS       NM_001436762            9453 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus vir like m6A methyltransferase associated
            (Virma), transcript variant 1, mRNA.
ACCESSION   NM_001436762 XM_063287575
VERSION     NM_001436762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9453)
  AUTHORS   Hong,H., Xu,G., Bao,G., Zhang,J., Chen,C., Chen,J., Wu,C.,
            Jiang,J., Huang,J., Huang,H. and Cui,Z.
  TITLE     VIRMA promotes neuron apoptosis via inducing m6A methylation of
            STK10 in spinal cord injury animal models
  JOURNAL   CNS Neurosci Ther 30 (3), e14453 (2024)
   PUBMED   37721438
  REMARK    GeneRIF: VIRMA promotes neuron apoptosis via inducing m6A
            methylation of STK10 in spinal cord injury animal models.
REFERENCE   2  (bases 1 to 9453)
  AUTHORS   Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
            Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   3  (bases 1 to 9453)
  AUTHORS   Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
            Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
            and Liu,J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9453)
  AUTHORS   Schwartz,S., Mumbach,M.R., Jovanovic,M., Wang,T., Maciag,K.,
            Bushkin,G.G., Mertins,P., Ter-Ovanesyan,D., Habib,N.,
            Cacchiarelli,D., Sanjana,N.E., Freinkman,E., Pacold,M.E.,
            Satija,R., Mikkelsen,T.S., Hacohen,N., Zhang,F., Carr,S.A.,
            Lander,E.S. and Regev,A.
  TITLE     Perturbation of m6A writers reveals two distinct classes of mRNA
            methylation at internal and 5' sites
  JOURNAL   Cell Rep 8 (1), 284-296 (2014)
   PUBMED   24981863
REFERENCE   5  (bases 1 to 9453)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   6  (bases 1 to 9453)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_063287575.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.14777.1,
                                           SRR26643295.20652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000005.1  29758623-29758709
            88-203              JAXUCZ010000005.1  29766057-29766172
            204-290             JAXUCZ010000005.1  29769768-29769854
            291-339             JAXUCZ010000005.1  29777954-29778002
            340-508             JAXUCZ010000005.1  29782461-29782629
            509-631             JAXUCZ010000005.1  29783958-29784080
            632-904             JAXUCZ010000005.1  29784916-29785188
            905-2045            JAXUCZ010000005.1  29788126-29789266
            2046-2534           JAXUCZ010000005.1  29794315-29794803
            2535-2689           JAXUCZ010000005.1  29796379-29796533
            2690-2772           JAXUCZ010000005.1  29797906-29797988
            2773-2866           JAXUCZ010000005.1  29801477-29801570
            2867-3411           JAXUCZ010000005.1  29801711-29802255
            3412-3647           JAXUCZ010000005.1  29802767-29803002
            3648-3900           JAXUCZ010000005.1  29803600-29803852
            3901-4118           JAXUCZ010000005.1  29806594-29806811
            4119-4251           JAXUCZ010000005.1  29809114-29809246
            4252-4404           JAXUCZ010000005.1  29811502-29811654
            4405-4565           JAXUCZ010000005.1  29812069-29812229
            4566-4662           JAXUCZ010000005.1  29813736-29813832
            4663-4829           JAXUCZ010000005.1  29815947-29816113
            4830-5161           JAXUCZ010000005.1  29816841-29817172
            5162-5305           JAXUCZ010000005.1  29819674-29819817
            5306-9453           JAXUCZ010000005.1  29820557-29824704
FEATURES             Location/Qualifiers
     source          1..9453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..9453
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="vir like m6A methyltransferase associated"
                     /db_xref="GeneID:313061"
                     /db_xref="RGD:1559904"
     exon            1..87
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..5460
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein virilizer homolog isoform 1"
                     /protein_id="NP_001423691.1"
                     /db_xref="GeneID:313061"
                     /db_xref="RGD:1559904"
                     /translation="MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIP
                     PGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRP
                     NSKVNTDGLVLRGWYNCLTLAIYGSVDRVLSHDRDSPPPPPPPPPPPQPQPTLKRSLK
                     HADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYF
                     EPISPDRNSVPQEGQYSDEGEVEEEQQEEGEDDEDDVDVDEEEDEDEDDCHTVDSIPD
                     DDEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVP
                     PMTYDPYDRELVPLLYFSCPYKTTFEIEINRMKDQGPDKENSGAIEASLKLTELLDLY
                     HEDRGAKWVTALEEVPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVAFRQPIA
                     LNVRQLKAGTKLVTSLAECGAPGVTELLQAGVISVLFDLLFADHVSSSLKLNAFKALD
                     SVISMTEGMEAFLRSTQSEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEI
                     KRLGDHIAEKTSSVPNPSEPDHDTDAVLERANPDYENEVEASMDMDLLESSNISEGEI
                     EKLINLLEEVFHLMETAPHTMIQPPVKSFPTIARITGPPERDDPYPVLFRYLHSHHFL
                     ELVTLLLSIPITSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYD
                     QDEEEGLQSDGVDDAFALWLQDSTQTLQCVTELFSHFQRCTASEETDHSDLLGTLHNL
                     YLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILILV
                     VVQSSSDVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYV
                     KQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFI
                     RVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDM
                     RVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANN
                     TWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLW
                     SMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVE
                     DLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDEKYAEIFQDL
                     LALVRSPGDSVIRQQCVEYVTSILQSLCDQDIALILPSPSEGPGSELEQLSNSLPSKE
                     LMAAICDCLLATLANSESTYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLL
                     KRVVSTFSKDTGELTSASLDFMRQILNSDAMGCCGDDSGLMEVESAHPPRTMSINAAE
                     LKQLLQSKEESPESLFLELEKLVLEHSKEDDSLESLLDNVIGLKQMLESSGDPLPLSD
                     QDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLI
                     ELSEKCCSDFDLHSELERSFLSEPSSPGRAKTTKGFKLGKHKHETFITSSGKSEYIEP
                     AKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQD
                     GIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSW
                     SAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWAST
                     NSGSGGSRGKFVSGGSGRGRHVRSFTR"
     misc_feature    37..729
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="Virilizer, N-terminal; Region: VIR_N; pfam15912"
                     /db_xref="CDD:464938"
     misc_feature    37..729
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /note="Virilizer, N-terminal; Region: VIR_N; pfam15912"
                     /db_xref="CDD:464938"
     exon            88..203
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            204..290
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            291..339
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            340..508
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            509..631
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            632..904
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            905..2045
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2534
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2689
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2772
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2866
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3411
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3647
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3900
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4118
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4251
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4404
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4565
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4566..4662
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4829
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..5161
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5305
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..9453
                     /gene="Virma"
                     /gene_synonym="RGD1559904"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggtcccc cgcccgcggc gaacatggcg gtggactcgt ccatggagct gctattttta
       61 gatactttta aacatccaag cgctgagcaa agttctcata tagatgtggt tcgttttcca
      121 tgtgtggttt atatcaatga agtccgagtt atacccccgg gagtacgagc ccatagtggc
      181 ttacctgaca acagagcata tggggaaaca tctcctcaca catttcaact agacttattt
      241 ttcaataacg taagcaaacc aagtgctcca gtttttgata ggttgggaag tctggaatat
      301 gatgagaata cgtctatcat ctttagacca aactcgaagg taaatactga tggtctggtg
      361 ctaagaggct ggtacaactg tctgaccctg gcaatatatg gatcggtgga tagagtgcta
      421 agccatgaca gagactctcc tccacctcct cctccacctc caccccctcc ccagccacag
      481 ccgacactga aaaggagcct aaaacacgct gatggtgaga aagaagatca gtttaatgga
      541 agtcctccaa gacctcagcc ccggggacca agaactcctc ccggacctcc tccacccgat
      601 gacgatgagg atgaccctat gtctttgcca gtgtctggtg acaaagaaga agatgttccc
      661 cacagagaag attactttga gcccatttct cctgatagga attccgtccc gcaggaaggt
      721 cagtattccg atgaggggga ggtcgaagaa gaacagcagg aagagggaga agatgatgaa
      781 gatgatgtgg atgtagacga agaagaggat gaagatgagg atgactgcca tacagtggac
      841 agtatccctg atgatgatga ggaagatgaa gaggaggagg gtgaagaaga tgaagaaggt
      901 gaaggggacg atggctacga gcagatctcc agtgatgaag atgggattgc tgacttggaa
      961 cgtgaaactt tcaagtatcc aaacttcgat gttgaataca ctccggaaga cctggcgtct
     1021 gttcctccta tgacatacga cccctatgac agggagctgg taccactctt gtatttcagc
     1081 tgcccataca aaactacttt tgaaattgaa atcaatagaa tgaaggatca gggtccagat
     1141 aaagagaatt caggggcaat agaagcttcg ttgaagttaa ctgagctgct agatctgtat
     1201 cacgaagaca ggggcgcaaa gtgggtgaca gctctagaag aagtcccaag tttaattata
     1261 aaaggattaa gctatttgca gttgaagaac acaaaacaag actcccttgg ccagttggta
     1321 gactggacaa tgcaagcttt aaatttacaa gtagcctttc gccagcccat agccttaaat
     1381 gtcagacagc tcaaagctgg gaccaagcta gtgacctcat tagcagaatg tggggctcca
     1441 ggagtcacag aattgctaca agcaggagtg atcagtgtat tgtttgatct cctatttgct
     1501 gatcatgtct catcgtccct taagttaaat gcttttaaag ctttggacag tgtcattagc
     1561 atgaccgaag gaatggaggc ctttttaaga agcacccaaa gtgagaaaag tggctatcaa
     1621 aaactgctgg agctcatact tctagatcag acggtgaggg ttgtcactgc tggctcagct
     1681 attcttcaaa aatgccattt ctatgaagtc ttgtcagaga ttaaaagact cggtgaccat
     1741 atagcagaga agacttcatc tgttcccaac cccagcgagc ctgatcacga cacagatgct
     1801 gtactggaga gagcaaaccc agattatgag aatgaagtag aagcttctat ggacatggat
     1861 ctattggaat cctcaaatat aagcgaaggc gaaatagaaa agcttattaa tcttttagag
     1921 gaggtttttc atctaatgga aactgcacct cacacaatga tccaacctcc tgttaagtct
     1981 ttcccaacaa tagcacggat tactggacct ccagagaggg atgacccata tcctgttctc
     2041 tttaggtatc ttcacagcca tcacttcctg gagttggtca ccttgcttct gtcgattcca
     2101 ataacaagtg cccatcccgg agtgctgcaa gccaccaagg acgttttaaa gtttctcgca
     2161 cagtcacaaa agggccttct cttttttatg tcagaatatg aagcaacaaa cttgttgatc
     2221 cgagctctgt gccaccttta cgatcaagac gaagaggagg gccttcagtc tgacggggtt
     2281 gacgatgcct ttgccttgtg gctgcaggac tcaactcaga ctctccagtg cgtcacagaa
     2341 ctgttcagcc attttcagcg ttgtacagcc agtgaggaaa ctgaccattc ggatctcctg
     2401 ggcaccctcc acaatcttta tttgattact tttaatcctg ttggaagatc agctgttggc
     2461 catgttttca gccttgacaa aaaccttcag agtctcatta ctctaatgga gtactattcc
     2521 aaagaagccc taggtgattc caagtctaag aagtcagtag cttataatta tgcatgcata
     2581 cttattctgg tggtggttca gtcttccagt gatgtccaga tgctggagca gcatgcagca
     2641 tctctcttga agctttgcaa agcagatgaa aataatgcta aactgcaaga acttggcaag
     2701 tggcttgaac ctctgaaaaa cctcagattt gaaattaact gcatcccaaa tctaattgaa
     2761 tatgttaaac agaatattga taacttgatg actgcagaag gagttggcct taccactgcc
     2821 ttacgtgttc tctgtaatgt ggcttgtcca ccacctcctg tagaaggtca acaaaaagac
     2881 ctgaagtgga accttgctgt tattcagctt ttttctgctg aaggaatgga cacctttatt
     2941 cgggttctgc aaaagttgaa cagtattttg acacagcctt ggaggctcca tgtgaacatg
     3001 gggactaccc tgcacagagt tactaccatt tcaatggctc gctgcacgct cacccttctt
     3061 aaaactatgc tgacagagct cctgcgaggc ggatcctttg agtttaagga catgcgagtt
     3121 ccttcagcac tcgttacttt acacatgctc ctgtgctcta tccctctctc aggtcgtttg
     3181 gatagcgatg aacagaaaat tcagaatgat atcattgata tcttattgac ttttacacaa
     3241 ggagttaatg agaagctcac aatctctgaa gagactctgg ccaataatac ttggtcttta
     3301 atgttaaagg aagttctctc ttccatcttg aaggttcctg aaggcttctt ctctggactc
     3361 atactccttt cagagctgct gcctcttccc ttgcccatgc agaccacgca ggttattgag
     3421 ccacatgata tatcagtggc actcaacacc cgaaaattgt ggagcatgca ccttcatgtt
     3481 caagcaaagt tgctccaaga aatagttcgt tctttctctg gcacaacctg ccagcccatt
     3541 cagcatatgt tacggcgtat ttgtgttcag ttgtgtgacc ttgcctctcc aactgctctt
     3601 ctgatcatga gaactgtgtt ggatttgatt gtagaagact tgcaaagcac ttcagaagat
     3661 aaggaaaagc agtatactag ccaaaccacc aggttgcttg ctcttctcga tgctctggct
     3721 tcacacaaag cttgtaaatt agctattttg catctaatta atggaactat taaaggcgat
     3781 gaaaagtatg cagagatatt ccaggatctt ttagctttgg tgcgatctcc tggggacagt
     3841 gttattcgcc agcagtgtgt ggaatatgtc acatccattt tgcagtctct ctgtgaccag
     3901 gacatcgcac tcatcttgcc gagcccttct gaaggtcccg gctctgagct ggagcagctt
     3961 tccaactccc tcccgagtaa agagctgatg gctgccatct gtgactgtct gctggccaca
     4021 ctagccaact ccgaaagcac ttacaactgt ctgctgacgt gtgtgcgcac aatgatgttt
     4081 cttgcagagc atgattatgg gttgtttcac ttaaaaagtt ctttaaggaa gaacagtagt
     4141 gctctgcata gcttgctgaa gcgagtggtc agcacattca gtaaggacac tggcgagctt
     4201 acgtcagcgt ctctggactt catgagacag atcctcaact ctgatgcaat gggctgttgt
     4261 ggagacgaca gtggtctcat ggaggtagag agcgctcacc caccccggac gatgagtatt
     4321 aacgctgcag agctaaaaca gctcctacag agcaaagaag agagtccaga gagtctgttt
     4381 cttgaactag agaagctcgt tttggaacac tcaaaagagg atgacagtct ggagtccctg
     4441 ctggataacg taattgggct gaagcagatg ctggagtctt caggtgaccc tttgcctctc
     4501 agtgaccagg atgtagagcc agtcctgtca gctccagagt ctctccagaa tctattcaac
     4561 aacaggactg cgtatgtgtt ggctgatgtc atggatgatc agttgaaatc tatgtggttt
     4621 actccatttc aggctgaaga gatcgataca gatctggatt tggtaaaggt tgacttaatt
     4681 gagctctcgg aaaagtgctg cagtgacttt gacctgcact cagaattgga gcgctccttt
     4741 ttgtcagaac cgtcatctcc aggaagagcc aagaccacga aggggtttaa actagggaag
     4801 cataagcacg agacgttcat aacttcaagt ggaaaatctg aatacattga acccgccaaa
     4861 cgagctcacg ttgtgccccc accaagaggc cggggccggg gaggatttgg ccagggcatc
     4921 cggccgcatg atattttccg tcagagaaag cagaacacga gtaggccacc gtctatgcat
     4981 gtggatgact ttgttgcagc cgaaagtaaa gaagtggttc ctcaagatgg aatacctcca
     5041 cccaaacggc cgctcaaggt ctctcagaag atttcctccc gcggtggatt ttcaggcaac
     5101 cgaggagggc ggggtgcttt tcacagtcag aacaggtttt tcacaccgcc tgcttcgaaa
     5161 ggaaactaca gtcgtcggga aggaacaaga ggctccagtt ggagtgctca gaatactccg
     5221 agaggaaatt ataacgaaag ccgagggggc cagagcaact tcaacagggg ccctcttccg
     5281 ccattacggc cacttagctc cacaggttac cgccctagtc cccgggatcg agcttctcgg
     5341 ggccgtgggg ggctcggacc gtcctgggcc agtacaaata gcggcagtgg aggctcacga
     5401 ggaaagtttg ttagtggagg cagtggtaga ggccgtcatg tacggtcctt tactcgatag
     5461 acgtgctctt gggaacaccc caagtaaatg gacatttcat gaggacaaaa aacagacaga
     5521 ccttgaagga ccaatttaga cttagcagtt atatctggat tcatctgaga gaatattttt
     5581 atctgaagaa agcagatttt gtttgatact taatgagatt tcaataaaaa tccaaacttt
     5641 gtatatatgt ttgtatatat ttttcccatt tttatatggt atttatttag aaaatttcta
     5701 ggtagaaaga ggaaaactaa ataatttgtt ttgtattttt cttgcttata ctatagatat
     5761 ttccaaactt tcttcgcctg tgacaccctt tagtgtgtct cagggatttt ttcacagtgt
     5821 ccctaggcca aaagcaaact taatactttt gtttattaaa cagttaggtc caagcaaccg
     5881 aagactttcc accatcacca ctagtaactg gacaccactc gctcaaggcc tcacccttgg
     5941 aaacagcagc cttccctgtc cgggtccccg agcagtactg tttatcacac tgctgaacat
     6001 ttgtcacagt tgtgtgctgt catggaaagt catccagtgc tacccacgct gaaaatgtga
     6061 actacctcaa actagtagtt tgtgtggtcc agcagatgtt gctgtttcct caaaaattca
     6121 aaacgctcat gctcatttac gaaggtgccc accacacagt ttagtcatca tcattgctgc
     6181 accagaagaa gcaaaacacc tccttatgtt agagagaaat gcagactttg cttcaagttt
     6241 ggacctactg atgctatttt ataacatagt tatttaaagc ctaaaagttg gcttatccta
     6301 atatggttat tttgggaatc aagcatctac tttatattca gaaataaaac ttataacttt
     6361 gaccaaggag ccatatttcc cccaagatat gtcttaattc attgagccta tatacatggc
     6421 ataaaatata gagttctctt aaacaaaact aagtgtatga gtctcattcc atcccaacag
     6481 cctctgttct ggggaatcac ttgagtgcat ttaatatctg tttattaggc aaaaaggcct
     6541 tgaaaagttc agctttagaa ttgagggttt agcttactgg tagaagtact tgcctagcat
     6601 gtgtgataac cactagaagt gtgtatgtgt gtgtctctat gtgcacgtct ttgtgtatgc
     6661 acatgcatat gtgcgtgcgt gcatgcacgc atacatgcat gtgcatggaa agttcagccg
     6721 taaggattct gatgcttatg tacaaggtga tgaaaatttt cttaatagtc tggaacaatt
     6781 caagctctta gtctgctcac gctgctataa catagttaaa tagattagat ggatagtaac
     6841 aaaaatctct tagttccatg gtcaggcctt tggtataatc aggttctggt gaggcactcc
     6901 ttgaagattt ttcacatgct ctttctgtag ttgaggacct cttctatcat ggacagatgg
     6961 tttaaggagt ttgccaacct agattttgaa tcgtatttct acaccatctg aatcaagtac
     7021 ctacctttct ccactcatag catcagaatg tacctctttt gctgggctgt agagtgaatg
     7081 gcacatctgt aaggagtctt gacttctttt ctcatttatt tgaaccctgc atttaggata
     7141 ttttcagttt gtatcagttt gtgtctgtac tgtgatggtt agtgttgtcc acttgatagt
     7201 atttagaatt acgggaggtc ctggggtctc tggataagcc ggatggggga taatttaaat
     7261 taattacact gcagtaggat tactagccat catggttggc acagttccct gggtgagatc
     7321 ctgcctggac cacagaagta gagaaaggag atgaatgcta gcaggctatg tagaatgtaa
     7381 ggattaattc accatgtaga aatagaattc caaacaccta ttgtgatttg tcatttcaaa
     7441 aatgagtcag atgtgcatgt acatttagat ccgtgtataa ctgcacttct tcagaatgag
     7501 tgactatgag tgtattttgt ctcagtgatg tatatgttta cattagacat ttcagtggtg
     7561 tcgtttggta tttgggaatt aaagctgcag aatatctttg gggacaaagt taatttcatc
     7621 tctagcacaa atagaggata ggatcatttg tattcattcc ataaaaatag aaaatactaa
     7681 aatactgatg ggcaggattg gggatttagt tcagtggtaa agcacttgcc tagcaagtac
     7741 aaggccctgg gttcggtccc cagctccgaa aaaaagaaaa aagaaggagt ttgtaaaaac
     7801 tgatggcctt tattttagac ttgctggtat tagtttcaga cagtagaagt tcagttaggt
     7861 tagttttatt gtacaaaacc ttgggaaaac ctccaagatg caatcaaaag atagaacttg
     7921 tctcctgagc ttgtctcaac ttgtcttggt gccttagttc agtccttaat attaaagcaa
     7981 ggtattggct tctttttatg ctttatttac ttattgtatg tcggtctgcg tgatgtatgg
     8041 gggtctgtgc cacagcatgt ctatgtaggt cagagggcaa cttggtagag ttggcacttc
     8101 ctttctgtga gttctgggga tcaaactcag gcttggcaag ctctttaccc actgagccat
     8161 cttaccagcc taaagccagg tattttctgc ctttgccagg aagtgtacaa tgtattgaag
     8221 acaatgactg cataaacagt gaacttaaaa agagaaataa taaaatctta ggttatcagt
     8281 atgaaatgac ccagaattct taagtaatcc aaccagtaca tttcaatgta attgtattat
     8341 aggtgtttta cagtagctaa cttcaaaata gctaaatagg tataatggga gagcatcttg
     8401 atgtcacact tttataattt cagactaata tccttttttg gaactatata tggaggcaaa
     8461 gatggaaaat aatgcacttt ttagtttcgt aaatttagga ctgggtgtgg tggtagacat
     8521 ttctaatctc agtacctggg aggccgaggc aggcagcagt gggttccagg tgacataacg
     8581 ggaccctgta taaacaaaat aattttaaag gaagtaatgc agagatgtta aaggggccat
     8641 aaaagcccat agtctagaga aatgacacag gctgaaatac tagcagagta gcaaatggaa
     8701 ggcagcaggt gagagctagg gaagaggcca gttgacacca gttgatacca gtgggggggg
     8761 gggcagctaa acaatgggaa ctttacagtg ataggtggga ggtctgaact tcccacctgc
     8821 ttcatagaat tacaaagttt ttgtggtaaa taagacctat ggttgtaacc attttcttaa
     8881 aatctttaaa aaaaataaat gtatgtgtgg atattgtgca ctcaagtgca gatgcccagg
     8941 gtcagaggta aagggtcctg gagttgtgag atacaggcag ttgtgagcta ctctgtagtg
     9001 gtcctgggaa ccaaacttat gtcctccaag atttacagca gcaagtattc ctaaccactg
     9061 agccatcttt cagcccttct tgttttttaa aaaaaaaaaa aaaagtctgg ttgtaggcac
     9121 ctttcactgc tgagctctct ctggccctgt ccttaatttt tgacataggg tctctgactg
     9181 aaactggagc tcactgatct tagtgtctct atctccctgg cacttagatt ccgtgtgagt
     9241 cactgcacct gacattgtgt gggtgctagg gatccaaact ctggtcctaa tgattgtgtg
     9301 gcaaacactt tcccagctga gccagcttcc aaatctgtga aatgtaactt ttgacaacgt
     9361 ggttattgtt agcgtgtcat ttacattttg gaggttttaa aataaatttt tgcacacttt
     9421 tcattttcaa gcaaaataaa atagtgaaat gta
//
LOCUS       NM_001436757            2467 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 68 (Tmem68), transcript
            variant 1, mRNA.
ACCESSION   NM_001436757 XM_006237827
VERSION     NM_001436757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006237827.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.443737.1,
                                           SRR26643286.15762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000005.1  21322310-21322426   c
            118-204             JAXUCZ010000005.1  21318760-21318846   c
            205-593             JAXUCZ010000005.1  21316424-21316812   c
            594-758             JAXUCZ010000005.1  21304734-21304898   c
            759-952             JAXUCZ010000005.1  21301659-21301852   c
            953-1013            JAXUCZ010000005.1  21296573-21296633   c
            1014-1153           JAXUCZ010000005.1  21294405-21294544   c
            1154-2467           JAXUCZ010000005.1  21291897-21293210   c
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2467
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
     exon            1..117
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            118..204
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            205..593
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1258
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="isoform a is encoded by transcript variant 1;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform a"
                     /protein_id="NP_001423686.1"
                     /db_xref="GeneID:312946"
                     /db_xref="RGD:1309006"
                     /translation="MINNNQTCAAGQDSVPYVTCMLHVLEEWLGVEQLEDYLNFANHL
                     LWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDG
                     HAAVWHGYEVHGMEKIPEGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVF
                     KIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKG
                     FAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTF
                     LGDPIPYDPEVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAN"
     misc_feature    575..1195
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    575..1195
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: MGAT-like; Region:
                     LPLAT_MGAT-like; cd07987"
                     /db_xref="CDD:153249"
     misc_feature    order(653..655,662..664,671..673,716..727,860..868)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     misc_feature    order(653..655,662..664,671..673,716..727,860..868)
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     exon            594..758
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            759..952
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1013
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1153
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2467
                     /gene="Tmem68"
                     /gene_synonym="RGD1309006"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcaggtg tttaaagaaa gccggcgcta tctgagagtc cgcctctccg gggtcaaccg
       61 cggactagct gccgacgtcg ccgaggataa cctgatcttc tgtgacttcc ttgtcaggtt
      121 cacccccgct gcagcagggc tctgctctct gactgagtgg tgctgtgtta catggatctg
      181 tcatttctat tcagtcatca gttggcattg cagtaacacc tatggcaatg aagaaagaga
      241 cagaatttgg gattttcatc taaggaaaat gataaataac aaccagacgt gtgctgcagg
      301 gcaggactcc gtgccctacg tgacctgtat gcttcacgtg ctggaagagt ggttgggtgt
      361 ggaacagttg gaggactacc tgaattttgc gaaccatctc ttgtgggtct tcaccccgct
      421 gatcctttta atacttccgt actttaccat cttccttctc taccttacta ttattttcct
      481 ccacatctat aagaggaaga atgtgttaaa agaagcctac tctcacaact tgtgggatgg
      541 cgcgaggaaa acagtggcaa ccctgtggga tggacatgcg gcggtttggc atggttatga
      601 agttcacggg atggaaaaga taccagaagg accagcactt ataatttttt atcatggagc
      661 tattcccata gacttttact acttcatggc taaaattttc atccacaaag gcagaacttg
      721 ccgagtggta gctgaccact ttgtctttaa aatcccaggg ttcagtttat tacttgatgt
      781 attttgtgct cttcatggac caagagaaaa atgtgttgaa atcttgagga gtggtcactt
      841 gttagctatt tcaccgggtg gagttcgaga agccttactt agtgatgaaa cctacaacat
      901 catatggggt aatcgtaaag gctttgctca ggttgcaatc gatgcaaaag tgcccattat
      961 tcctatgttt acacaaaaca tccgagaagg atttagatca ctcggaggaa caagattgtt
     1021 taaatggctt tatgaaaaat tccgctatcc gtttgctcca atgtatggag gttttcctgt
     1081 gaagttgcgg accttcttgg gtgatcctat tccgtatgac ccagaggtaa cagcagaaga
     1141 attagctgaa aagactaaga acgctgttca agctttgatc gacaagcacc aaaggatacc
     1201 ggggaacatt aggagtgctt tgctggaccg ctttcataaa gagcagaagg ctaattgaca
     1261 gataatttcg tgtgtctcta atgccaagtt tgcatctgtg gtactgcctt ttaaactttt
     1321 gtaggttgta taatagtctt tttaaaacct gctaatgagc atctttcttt agaatttaaa
     1381 ctttctatgg ttaatcttac cctttcaatc agttttgtca aatgtagtaa gtaactcacc
     1441 atttgcttga ctcagaagat gatcatgttg catttgcaat ccttagtagt atatgatagg
     1501 cacaagtctt cctggatacc agcagtctag gttaggcaga cttcactaaa ttatgcttct
     1561 gtgtttgtgt ctgttgtgcc aatgggatgg tgagaggtac ctgagctggg gtgtagcact
     1621 tgcttagttt aggtgagcgg tgcctttgta tccatccttc attccactca caactgctgg
     1681 taagttgtga aacgcttttg cacctccgtg gtttatgtta agcatggtaa tactgtggtg
     1741 gtgaacatta agttgcttat gtctactgtg atatatccgt atctatatat ctgatagata
     1801 tctgtagtga gaaatctgta attgaattga ttcctgaatc ctttaggagt tatgtacatt
     1861 tttgtttatt gggtattgaa attactcctt cagggatgat gtccagttgc caagcacaat
     1921 gaaagagatg tactattttg taaatcaaat cattgttatt tgtagtattt attaacagag
     1981 ttgtttggta tttattttaa acaaggatct aagtaaatgt ataggatgga ttgtcagcac
     2041 gtgtcttaca cggtgtaaag ataaaatcgt gggcacgctc tgcagtttat gttagagcag
     2101 atcctaggct gaggagtgac aactgaggaa gctctgcctc gcttgtccca gggctcgctt
     2161 ccgtgctctg cagccagtca cgtggttata tctgtaaaat gtacttgaat gatgaatttc
     2221 tgtaaacatg gagtcctctg aaaatgtaat tactttgaat tgttgtcttc ttgaaaactt
     2281 attttaaaag tatttaaaca gccaagtatc atgaattcat cgcagtgtgt cttccccctt
     2341 tgcagtactt gggttttata tggacttttt aactacaagt gtatatttgt gatatgtata
     2401 atgtatgtat aatgtatata gaaatggtgt gaaaataaag ctgaactgca actcctctct
     2461 agtaaaa
//
LOCUS       NM_001436736            2413 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus pleckstrin homology domain containing N1
            (Plekhn1), transcript variant 1, mRNA.
ACCESSION   NM_001436736 XM_006239565
VERSION     NM_001436736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Kuriyama,S., Tsuji,T., Sakuma,T., Yamamoto,T. and Tanaka,M.
  TITLE     PLEKHN1 promotes apoptosis by enhancing Bax-Bak
            hetro-oligomerization through interaction with Bid in human colon
            cancer
  JOURNAL   Cell Death Discov 4, 11 (2018)
   PUBMED   29531808
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Maeda,A., Uchida,M., Nishikawa,S., Nishino,T. and Konishi,H.
  TITLE     Role of N-myristoylation in stability and subcellular localization
            of the CLPABP protein
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1249-1256 (2018)
   PUBMED   29180010
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Nishino,T., Matsunaga,R., Jikihara,H., Uchida,M., Maeda,A., Qi,G.,
            Abe,T., Kiyonari,H., Tashiro,S., Inagaki-Ohara,K., Shimamoto,F. and
            Konishi,H.
  TITLE     Antagonizing effect of CLPABP on the function of HuR as a regulator
            of ARE-containing leptin mRNA stability and the effect of its
            depletion on obesity in old male mouse
  JOURNAL   Biochim Biophys Acta 1861 (11), 1816-1827 (2016)
   PUBMED   27616329
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Sano,E., Shono,S., Tashiro,K., Konishi,H., Yamauchi,E. and
            Taniguchi,H.
  TITLE     Novel tyrosine phosphorylated and cardiolipin-binding protein
            CLPABP functions as mitochondrial RNA granule
  JOURNAL   Biochim Biophys Acta 1783 (6), 1036-1047 (2008)
   PUBMED   18191643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006239565.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.25210.1,
                                           SRR26643294.24142.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000005.1  172094731-172094855 c
            126-225             JAXUCZ010000005.1  172094539-172094638 c
            226-372             JAXUCZ010000005.1  172091810-172091956 c
            373-453             JAXUCZ010000005.1  172091631-172091711 c
            454-526             JAXUCZ010000005.1  172091478-172091550 c
            527-651             JAXUCZ010000005.1  172091200-172091324 c
            652-765             JAXUCZ010000005.1  172091015-172091128 c
            766-846             JAXUCZ010000005.1  172090828-172090908 c
            847-922             JAXUCZ010000005.1  172090143-172090218 c
            923-1071            JAXUCZ010000005.1  172089852-172090000 c
            1072-1212           JAXUCZ010000005.1  172089578-172089718 c
            1213-1359           JAXUCZ010000005.1  172089217-172089363 c
            1360-1500           JAXUCZ010000005.1  172088916-172089056 c
            1501-1728           JAXUCZ010000005.1  172088527-172088754 c
            1729-1777           JAXUCZ010000005.1  172088244-172088292 c
            1778-2413           JAXUCZ010000005.1  172087524-172088159 c
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2413
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="pleckstrin homology domain containing N1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
     exon            1..125
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="upstream in-frame stop codon"
     CDS             43..1881
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology domain containing, family N member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family N
                     member 1 isoform 1"
                     /protein_id="NP_001423665.1"
                     /db_xref="GeneID:298694"
                     /db_xref="RGD:1311019"
                     /translation="MGNSHCVPQTPRRLRASFSRKPSLKGNREDSARKLAGLFGTEAR
                     PDGDTAANKIFHYIPGTDILGPENHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKV
                     QLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELSICPIDGSREHAFQI
                     TGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLRQCHSAPPQGSLGDKLPWTQLWRA
                     HGCEPMNSAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLNFKGELPLSAI
                     HINLEEKEKEIRSFLIEGRLINTIRVVCASYEDYSQWLLCLRTVSHRDGAHLLPGPES
                     FPGLQRPTQVLGRGRGSLSSNGRTSRKLECPVFPTSQSLPEPSVPTTIGVPAHPVPNQ
                     TNSNCVSTGQTKVELRHSGSSQFPRGKAQREVSGSTAPLPLHLDLTKMSVLNLDSGPE
                     AQDCSPDIPHSPLYADPYTPPAIAHHKITDIQGLDEFLCAVQTSPGPELSSPFPSVSV
                     SVPVSDSNSGISSSPRPLGSHLLSKKGALQSRASQRHRGSIKSRAPQPSDFPQLVTPA
                     REGTPSSLPPPPDEEAPIWNKTSSPSHQKWSHPRKPAVEGGFIQWI"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    328..606
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     misc_feature    706..1065
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /note="Pleckstrin homology domain containing family N
                     member 1Pleckstrin homology-like domain; Region:
                     PH_PLEKHN1; cd13323"
                     /db_xref="CDD:270132"
     exon            126..225
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            226..372
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            373..453
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            454..526
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            527..651
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            652..765
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            766..846
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            847..922
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1071
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1212
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1359
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1500
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1728
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1777
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2413
                     /gene="Plekhn1"
                     /gene_synonym="RGD1311019"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgtcg acctgccctg cccaagctag cagctgccat ccatggggaa cagccactgc
       61 gtccctcaga cccccaggag gctacgggcc tccttttcca gaaaaccctc gctcaaggga
      121 aacagagaag acagcgccag gaagctggct ggcctgtttg gcaccgaggc taggcctgat
      181 ggggacaccg cagctaacaa gatcttccac tacatccctg ggacggacat cctgggccca
      241 gaaaatcatc cagaaaacct ggaacagcca ttcctgagtg tattcaaaaa agggtggcgg
      301 aggacacctg tgaggaacct aggcaaggtg gtgcactatt ccaaggttca gctgcggttc
      361 cagcacagcc aggacatcag tgactgctat ctggaactgt tcccctccca cctgtacttc
      421 caggcccatg gttctgaagg acttacattc caggggctgc taccactgac ggaattgagc
      481 atctgcccga ttgatgggtc cagagagcat gccttccaga ttacaggccc actgcctgcc
      541 ccactccttg ttctctgcca cagtgaggcc gagctcagcc attggctcta ccacctggaa
      601 aagcaaatgg ctctcctggg tctgcggcaa tgccactcag cacccccaca gggttctcta
      661 ggagataaac tcccctggac ccagctatgg cgagcgcacg ggtgtgaacc catgaacagc
      721 gcaatctgtg cctcaagggt caagctgcag catctgccct cccaggagca gtgggaccgg
      781 cttctggtac tgtacccagc atccctggcc atcttctctg aggagccaga aggccttaac
      841 tttaaggggg agcttccact aagtgccatc catatcaact tagaagagaa ggaaaaagag
      901 atccgctcct ttctcatcga aggccgtctc atcaacacca tccgagtggt gtgtgccagt
      961 tatgaggatt acagtcaatg gctgctgtgc ctcaggacgg tctctcacag ggatggggcc
     1021 cacctgctgc ctggcccaga gagtttccca ggactacaga gacccacaca ggttttaggt
     1081 agaggccgag gttcactctc ttccaatgga cgaaccagcc ggaaattaga gtgtccagtg
     1141 ttccctacca gccaatccct ccctgagccc tcagtgccaa ccaccatagg tgtccctgcc
     1201 catcctgtgc ctaaccagac caactctaac tgtgtcagca ctggccaaac gaaggtagag
     1261 ctgaggcaca gtggcagtag ccagttcccc aggggcaaag ctcaaagaga agtatctggc
     1321 tcaactgccc cactgcccct gcacctggac ctgacgaaga tgagtgtcct gaacctagat
     1381 agtggcccag aggctcagga ttgctctcca gacattccac actccccgct ctatgctgat
     1441 ccctacacac caccagctat agctcaccac aagattacag acatccaagg cctggatgag
     1501 ttcctctgtg cagtacagac atcacctgga cctgaactat caagcccgtt cccctcagtc
     1561 tctgtgtctg tgcctgtctc tgactccaac tctggaatct ccagctcccc ccggcctctg
     1621 ggctcacact tgctctccaa gaaaggagcc ctgcagtcca gagcttccca gagacaccgg
     1681 ggttccatca agagcagggc cccacagccc tcagacttcc ctcagcttgt cacacctgcc
     1741 agagaaggta cacccagttc cctgccacct cccccagatg aagaggctcc tatctggaac
     1801 aagacttcct ctccctccca ccagaagtgg tcacatccca ggaagcctgc ggtggaaggg
     1861 ggattcatcc agtggatctg atggcccccg agtgagctgc tgcttctcaa aaaacacaaa
     1921 cagccagcac caaccgggat aagagtatgc agttcggcca gtcctttgac ttatattaaa
     1981 tacaccaggg cctaacccca tcaggtcgag ggtgtttcta gaattttgag gatagaggca
     2041 cctctcacca ggctctagct actcagcttt agcagttgga acaaatgaaa ggaggtaacc
     2101 ctaggaacga accagtgagg gacatcagta agattctgta caaccccaga agctatacct
     2161 ctagggggag aggtgggggt gctagtgcag gtctttactt agaagtgggg aacagcatgc
     2221 gtgtgaaata cagagcactg aaaaagtcag gttgtcaaac ccagcctgtg aagccagaag
     2281 gcatgagggt cagagatcat tagggtgaga gctattacaa gaagcaaagg agtataggaa
     2341 aagctagtac tgttgggtgc acagggtaag gttggtcaga aaaatgaaca ccataaacaa
     2401 gaaagagatt tta
//
LOCUS       NM_001436738            8520 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 5A1 (Slco5a1), transcript variant 1, mRNA.
ACCESSION   NM_001436738 XM_008763495
VERSION     NM_001436738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8520)
  AUTHORS   Kindla,J., Rau,T.T., Jung,R., Fasching,P.A., Strick,R., Stoehr,R.,
            Hartmann,A., Fromm,M.F. and Konig,J.
  TITLE     Expression and localization of the uptake transporters OATP2B1,
            OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
  JOURNAL   Cancer Biol Ther 11 (6), 584-591 (2011)
   PUBMED   21278488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_008763495.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14590.1,
                                           SRR26643289.14626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000005.1  11012033-11012246
            215-1605            JAXUCZ010000005.1  11013846-11015236
            1606-1738           JAXUCZ010000005.1  11063474-11063606
            1739-1950           JAXUCZ010000005.1  11066263-11066474
            1951-2115           JAXUCZ010000005.1  11081668-11081832
            2116-2314           JAXUCZ010000005.1  11108164-11108362
            2315-2474           JAXUCZ010000005.1  11121564-11121723
            2475-2716           JAXUCZ010000005.1  11123494-11123735
            2717-2781           JAXUCZ010000005.1  11129083-11129147
            2782-8520           JAXUCZ010000005.1  11135442-11141180
FEATURES             Location/Qualifiers
     source          1..8520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..8520
                     /gene="Slco5a1"
                     /note="solute carrier organic anion transporter family,
                     member 5A1"
                     /db_xref="GeneID:312907"
                     /db_xref="RGD:1307132"
     exon            1..214
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1605
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    639..641
                     /gene="Slco5a1"
                     /note="upstream in-frame stop codon"
     CDS             690..3242
                     /gene="Slco5a1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 5A1 isoform 1"
                     /protein_id="NP_001423667.1"
                     /db_xref="GeneID:312907"
                     /db_xref="RGD:1307132"
                     /translation="MDEGAAQSRAQEQLEAPSLVGAVQENFESESFRSKSLPVLHSAS
                     CRQNLSAGNADGKLALGSIEASGHQETHPGRNLIVPSPSAPSTSAGTTTELMDCNHRR
                     DPSKTVSVSSTLATLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIE
                     RRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALP
                     HFISPPYQIQELNASASNDGLCQNGNSTAILEPPPCPKDSGGNSHWIYVALFVCAQVL
                     IGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPR
                     NPVLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKFSADVVSD
                     DDIIKEKSNTSEQVNKKVSSMGFGKNVRDLPRAAVRILSNMTFLFVSLSYTAESAIVT
                     AFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLA
                     MICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHE
                     YEPVCGSDGITYFNPCLAGCINSGNLTTGVRNYTECTCVQSRQVITPPTVGQRSQLRV
                     VIVKTYLNENGYAVSGKCKRACNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEE
                     RPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYF
                     GLAAGLKFVGFIFIFLAWYSIKYKEDELQRRRCRDFPLSTVSEHVGRPSKAEKYSRTT
                     SCPAFSTQGESHEETALQKGFPGTTLTYPGPFSEAESSSADRGLDESLDAAL"
     misc_feature    1080..2717
                     /gene="Slco5a1"
                     /note="Solute carrier organic anion transporter 5 family
                     of the Major Facilitator Superfamily of transporters;
                     Region: MFS_SLCO5_OATP5; cd17404"
                     /db_xref="CDD:340962"
     misc_feature    1080..2717
                     /gene="Slco5a1"
                     /note="Solute carrier organic anion transporter 5 family
                     of the Major Facilitator Superfamily of transporters;
                     Region: MFS_SLCO5_OATP5; cd17404"
                     /db_xref="CDD:340962"
     misc_feature    order(1122..1127,1134..1139,1146..1148,1242..1244,
                     1530..1535,1539..1547,1554..1556,1614..1616,1623..1628,
                     1635..1637,2013..2015,2022..2027,2034..2042,2049..2051,
                     2136..2138,2148..2150,2271..2276,2286..2288,2298..2300,
                     2484..2486,2493..2498,2505..2510,2517..2519)
                     /gene="Slco5a1"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340962"
     misc_feature    order(1122..1127,1134..1139,1146..1148,1242..1244,
                     1530..1535,1539..1547,1554..1556,1614..1616,1623..1628,
                     1635..1637,2013..2015,2022..2027,2034..2042,2049..2051,
                     2136..2138,2148..2150,2271..2276,2286..2288,2298..2300,
                     2484..2486,2493..2498,2505..2510,2517..2519)
                     /gene="Slco5a1"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340962"
     exon            1606..1738
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1950
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2115
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2314
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2474
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2716
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2781
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..8520
                     /gene="Slco5a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcccgtgt gtctgtctgg ggaaaagagg cttgggtgac agaccagagg ttgggagaag
       61 agttagccag ctggactcgc agtctcactc cctgatttct cggcggcggg accgagaccg
      121 cctctgcagg aggctggccc atcttcccgc accgccgtcg tcctcctgtg gccgctcctc
      181 tcccagccag gcagattggt cgtcaccctc gctagtcggc agctttacga ccccatgtgt
      241 ctcaagcctt gcagtgggca ccgaacaccc ctgggaccac aaagtgggat gttgttcgga
      301 caatcgcctt aagtgacccg gtactgggcc caggtcgctc cagcttctgg ccaccgtctg
      361 agagacggcg gcggagggga tgagcaccgg acgcgcaaag cgcctaccgc gagctatccc
      421 cgggaggtgg acacctagca gggctcctcg aaggaccgcg cggaccttta cctcccccgg
      481 tacaaggtgg agaaaacttc ctgttgtgcc tcggggatag atgctctggg cacctcccta
      541 ctgctgagat gttctgcttt caggttctgc catcctcagc ccgggtctct ggaggggacg
      601 actgagtggg tccgacatca gcccatcctg caggtggatg aaaattgccg gaggccttgt
      661 atgggatcag caatcacatt ttaagagcca tggacgaagg ggctgcgcag tcccgggccc
      721 aagaacagct agaggcacct tccctggtag gagctgtcca agagaacttc gagtcggagt
      781 ccttcaggtc caagagttta ccggtcctgc acagcgcctc ctgccggcag aatctcagtg
      841 ctgggaatgc agatggcaaa ctggccttgg gcagcattga agcttcaggt caccaggaga
      901 cacatcctgg acggaacttg atagtcccta gcccttctgc tccatctact tctgcaggca
      961 ctacaacgga actcatggac tgtaatcaca ggagggaccc cagcaaaact gtgtcagtat
     1021 cttccacttt ggccacactc caggagagaa ggtgtcttta cgtggtcctt acggattctc
     1081 gctgcttcct agtgtgcatg tgttttctga ctttcatcca ggcgttaatg gtctcgggct
     1141 atctgagcag cgtcatcacc accatcgaaa ggcgctatag cctgaagagt tcggagtcag
     1201 ggctgctggt cagctgcttt gatataggaa acctagtggt ggtggtgttc gtcagctact
     1261 ttggtggccg tgggagaagg cccctgtggc tggccgtggg tggacttctt atcgccatcg
     1321 gggctgcgct cttcgcctta cctcacttca tctcgcctcc ctatcaaatc caagagttga
     1381 atgcttcggc ctccaatgat ggcctttgtc agaatggcaa ctccacagcc atcttggagc
     1441 ctcctccctg tcccaaggac tcgggaggaa acagtcactg gatctacgtg gctttatttg
     1501 tctgtgcaca ggttctcatt ggaatgggct ccacgccgat ttacaccctg ggaccaacct
     1561 atttagatga caacgtcaag aaagacaatg cgtccttgta cctagccatc atgtacgtca
     1621 tgggtgcact tggccctgca gtgggatact tactaggtgg gctactcatt ggcttttatg
     1681 tggatcccag aaatcccgtt ctccttgatc agaatgaccc tcgtttcatc ggaaactggt
     1741 ggagtggatt ccttctttgt gccattgcaa tgtttcttgt gatattccca atgtttactt
     1801 ttccaaaaaa gcttccacct cgacacaaga aaaagaaaaa attttctgcc gatgttgtta
     1861 gcgacgatga catcatcaag gagaaatcaa acacaagcga gcaagtgaac aaaaaagttt
     1921 cctcaatggg ctttggaaag aatgtcagag acctaccgag agcagctgtc aggatcttaa
     1981 gcaacatgac attccttttt gtgagtctgt catacacagc cgagagtgcc attgtcaccg
     2041 ctttcattac cttcatcccc aagttcatcg agtcacagtt tggtatcccg gcttccaatg
     2101 ccagcatcta cactggtgtc atcattgtcc ccagcgctgg tgttggcatt gtcctgggag
     2161 gctacatcat aaaaaaactg aagctcggtg ccagggaatc tgcaaaactc gcaatgatct
     2221 gcagtggggt gtctttgctg tgcttctcaa ccctgttcat tgttggatgt gaaagcatta
     2281 acctgggagg cataaacatc ccttacacaa cgggaccgtc tctgaccatg ccccatagga
     2341 atctgacagg aagttgtaat gttaattgtg gttgtaaaat acatgaatat gaaccagtct
     2401 gtggatcaga tgggatcacg tacttcaacc cttgtctggc tggctgcatt aacagtggca
     2461 atcttaccac gggggtccga aattacacag agtgcacttg tgtccaaagc cgacaagtga
     2521 tcaccccgcc cacagtgggg cagcgcagcc aacttcgagt ggtcatcgtg aagacctatc
     2581 tcaatgagaa cggctacgct gtgtctggga aatgcaagcg agcctgcaat accctcatcc
     2641 ccttcttggt cttccttttc atagttacct tcatcacagc gtgtgctcaa ccgtcagcca
     2701 ttatagtgac actcaggtcc gtggaagatg aggaaaggcc cttcgcattg gggatgcagt
     2761 ttgttctgct gcgaacactt gcatacattc ctactccgat ttactttgga gccgtgattg
     2821 acaccacctg tatgctctgg cagcaggagt gcggagtgca gggctcctgc tgggagtaca
     2881 acgtgacgtc atttcgtttc gtctactttg gcctggcggc tggcctcaag tttgttggct
     2941 ttattttcat tttcctggcc tggtactcta tcaagtacaa agaggacgag ctgcagaggc
     3001 ggcggtgcag agacttcccg ctgagcactg tgagcgagca tgtgggccgg cccagcaaag
     3061 ccgagaaata ctcccggact acatcgtgcc cagccttcag cacccagggg gaatcccacg
     3121 aggaaactgc tctgcagaag ggattcccgg gcaccacact gacatatcct ggacctttct
     3181 cagaagcaga aagttcctct gcagaccgag ggctggacga gagcctcgat gccgctctgt
     3241 agcatccctg ctggagcctg gagaaggaag acttgtgttg ttggttgagt tgaacacggc
     3301 aagttgagaa acacctgtgc cttctttcct tttgtaaacc tccacagaca caatcctcaa
     3361 accaacaata ctcagtacac acagccactg ttgctgaggg ctcggtacct caacgggacg
     3421 gacagcttcc ccctccaggg aggagtttag ctggatctgc cgccatgtct gctaggttca
     3481 cttaatgttc acagtccctt tgggtagaag cccgaggtcc acggttaacc gcgggaaagg
     3541 ctatgaccat acatatcatt agcatacact ccagacaaag gtgagcttca ccaggacttt
     3601 gcatttgcaa gtcaagagtt tttagatttg agcacctact gtgagctctg cagcaaagca
     3661 caactgaatt tgcctcaact atgcaatttg attggaaata gaaaagtgtg gcatgtccct
     3721 ttggctttca gagagcaaag cagaaacgtt tttccttagt ggaagctgaa tgttccctaa
     3781 agcactgtta atcgcaattt aagccataac agacttatca atcaggtaaa aaaaaaaaaa
     3841 ccttcaaatg cttcaatgct tcaaagaact gtattattgt gcaatggaag ggtttcttga
     3901 gaagtatttt ctctaagtcc attcactcca tcttaaggta gaccaagagg ctgctgagtc
     3961 gcacgtctgc tggcttgaat atataaacta cagtattctt tcctaagggg ctttaaaact
     4021 agtgtgctaa acagtacggc tggaaactaa tctgagatgc tcgatgggga ggaaatgatg
     4081 atcttctctt ccgaggaact ctcgcagctc taagggccca ctgaaactcg ctaagagtta
     4141 ctgctacttt gacatacaaa gtagttgata aagaaaatcc tgaggtaaga tggagtccca
     4201 actagggaac ttcacttctc tcttaacata ctggcaaatc tctactgatt gttttctctg
     4261 tgtggaaggt ggtcatggtt gccttggaga atgaatgatt cagtcatgaa agctgtaccg
     4321 tggatatgaa aatcactgcc cagcagacgg gaggtttgtc agctgaacac agaatatgat
     4381 catacttaaa taacgagttg gaatgtaaag aaagccagtc tgccatactg aatcctgtat
     4441 ggcaggattc atcgtttcac ggtgcccttt gcatggccgt tcttctgtct ttcctcaagt
     4501 ggctctgaga caggataatt cccttcctaa aggcacctca ggtccactga cagctgttta
     4561 tctttgtctc tcggctttag gctgctcagg atgctttctg tatggtgttc ttacgtcaga
     4621 ggcctcttgg caaacctttg tgcatccaac agttggtaac tcatgggatc tggctacact
     4681 ggaccaagat gtccaatgca ccataaaatt atagcctctc tgtcaaagaa ctcatgtcat
     4741 gtaaggtgac ctcaggaaat gtttcctcgt ctggaagaga ggtggctgac agaagggcca
     4801 tgatccattc aatcttggca gggcacacag gtagaattat gaatattctt attacagttc
     4861 ctggtataga attgacttcc tgcccgtgta ggaagcccac aagtcaagtg gttttctggg
     4921 taatgtctat aagaggcaga gctagtgcct aggtgaaaag aatcttcttt gactcctggg
     4981 cttggctgcc atggaggtgg gatgcttagc taggatagat tgtgaatgct gggtgtcaga
     5041 tttttgacca gagtaacaaa catgagaggt tttcataaag tcttgcaggt cagcccacgg
     5101 tgtactcttg ggagttggtg tccctcactg gcctctgtgg gtgactgtca ttctttagaa
     5161 gggataataa gtgtcctttg gtgttgatgc taagctgatt aggttgtaga gaggtggtgc
     5221 tttcttaatt tttttctgtg atattaagat attttattaa gaaacttctg gtggaattgg
     5281 tcctgttttg gtactaagat tgatgggctc accaagggtg attagaacgc ttctggtccc
     5341 ttcctctacc ttgaattcag ttcagcagtt tctgactgag cactggttat gtgttgatgc
     5401 cattcattgc tccttgagat cctatgggat gcagaggtca gaactcgaag accttggaag
     5461 tgcactacag catgcaaata ttaaatattg atattaagta gcaggtgtat cattaatgta
     5521 ctagtggtga ttgtacacta ggtcctgaaa gtcatgaggg aatgaagttc tgcattctat
     5581 atcagttaaa gattgctccc cagatgtctt agctccagta gcatcatctg aatattgcat
     5641 agccacggag tgagtatttc ataggcagtg ccattcaatt gtgctgatag aagaggtctt
     5701 ccgtttctgg caaactggtt gctttccttg tggccgcagc tcgtaacaga aactaactgc
     5761 tttctgagca taggcttttg ggttgttttg acaaaaggca agttgttctt gtatcatctc
     5821 tataaattaa attgtcttgt ttggcttcag tatgccaatc taatacgaag cttatggact
     5881 tagaaactcc caagggcaga gggaggaagg tggtggagga accttctttt gattttcttc
     5941 ctagtatgag gttcttgtgt tgtggaggtg ccctcacagg ttgaagagag ttaaaagtca
     6001 tttggaacac catgaggatg gggagaaaga gagcatttgt tggggtgaat atttgcagga
     6061 tggtttccca gcattcaaca cccactgcat tttccagttt aagagcgggc gaggaaacac
     6121 ggtttccttc agtggcgcag gcctgagctc aggaccttgc atatgacctc aggcccatgt
     6181 tccctgagca gcaccccagt cttctctgga gagcattttt tatttgtttg tttaaaaagc
     6241 agatttgaaa ccctaggctc agaaagttga agccagttct tcgggtggct cagagtagca
     6301 gtgacagggg atgagtgata tgtccactgt aaaataggtt agcacctatc actgtttgat
     6361 gtactattgt ttttgaagtt atagagacat tctttagaga catttatttc cttgtatgaa
     6421 tagaggaaac atagcacacg cccgtgtgaa ccacccacac ttcatgttta actagattct
     6481 caaagtaaat gttatttatg tagccaagta taatactaaa atcattcatt ataacttact
     6541 tcaaatgttt atttatgggt tgagtttaat tgagaacaca cccagtttgg ttattaatta
     6601 ggatcttagc agaatttcct aaagtgaaat gttatgaaga aagggttaat tctggctggt
     6661 tgaatctgag ctttgggtgt ttcaggtgta ttatttattt ctttctcttg tcagtagatt
     6721 aacatttctg ctaactcata gacagccgtg ggttttcaga gtcttagtga agatttaaaa
     6781 agaacataga aaatggacta caaaccacag actccgtctg tcacctcagg tgactgtgat
     6841 ggtaaactat atctttgcac tcagggaagc cagcacccac aggagttgct agagtggggc
     6901 tcccagaggt ctcagaaatc ctgtctcacc aaccatccaa aacttctgtt cggtccacag
     6961 ttctagctca cagtctttga tgaacttcta gccaggaagt gtcttctttg ttttgttttt
     7021 gaggctgctt cgtagaaccc tgtgtgcacc aaggaacatc actacagtgt ggagggaccc
     7081 aaagccccca tgggaactct cccatgagct ctgtagcaag gcaagcactt gcctaaggtg
     7141 ctagctgata ataacttgtg acagtacgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     7201 tctagaggtg cagagtgtga aggtatctgt tgctacatag gtacatgctg agtattctac
     7261 gtagcagata gaaaccagaa tgttgtaagt ccctgaaaag ccagattcgc taattctgtt
     7321 ctgcagactt gtgagtagcc ttccgcggtc aggagggatg gctggcaggt gaggctagtg
     7381 gcctcgtgta ctttgccttt tccctcttct gtcaactcac ctttactggt agtttgtggt
     7441 ctacctgact gtcgaaggcc aagaagatac tgctggcgtt gtctgtccca gacttcctgt
     7501 tgtgctgctt caaccagatt tgtgtttgtc tgaagaggtt taatttaagc agttcatttg
     7561 tcctcagcct tatggagggt caaatgtgac cagaaactca ccttactgct gttggctttg
     7621 gcaacattaa atataaaatg cctcggtgct aaagtgtttg cagacgcatg ttcctctctg
     7681 aagtcagtgt ttcagtgctt tgcgtttgga aatctggggg ttcccccgag aggacaaacc
     7741 ccgctgactt catttccaca gtccagaaac tctaatgcaa aactgggaag tgtactgggg
     7801 agtcctcttc tacacaaagg tcagtgggag aatgatcaga tgctaaaaaa taatttcaga
     7861 gagataaaaa cacatttaga taatcttcta tcttctacgg aaagtttcaa gccctgggag
     7921 ctgctcttca gctctgggtt ggatgctgtt gtctctgact ggtagtttac tctatatatg
     7981 gaaagtaaag aaactaatgt tattgaaaac aaaagtaatg gtaaggctgt tctaaagtaa
     8041 accgaggagt aagactcccc agtgggcatt tgtcttcagt atatacctct accccaaact
     8101 taaatgatga tctagagaat gaagtccaag gccagccttt actttgtagt gtaaggaaat
     8161 gtgaaactgt gtcaaactgg tattaggata tctgtggagt gtgcgtatgt gcgtgtgtgt
     8221 gtgtgtgtgt gtgcgtgtgt gtatctttct ggctgtgtgt ctatgtgctt ctctgtagag
     8281 gcatgtttgt gatgaaaggc tgctttgagt cataatgtag agtttcattt ttgtggtttt
     8341 tagaacaaat atttatttgg agatctgcta tggtaagggc cgtatgactt acttctttat
     8401 gtctaatgaa actgattgtc aaaggactaa taaacctggg tttacaacat catgaatact
     8461 tgattattga aaattaaggg ggggaaaagt tcaaaaaaaa taaagtgtgt tggattgaaa
//
LOCUS       NM_001436731            1756 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), transcript variant 1, mRNA.
ACCESSION   NM_001436731 XM_006239177
VERSION     NM_001436731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1756)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1756)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1756)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1756)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1756)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1756)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_006239177.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2784071.1,
                                           SRR22399481.1200869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  156718904-156719005
            103-192             JAXUCZ010000005.1  156766717-156766806
            193-314             JAXUCZ010000005.1  156784207-156784328
            315-428             JAXUCZ010000005.1  156788909-156789022
            429-570             JAXUCZ010000005.1  156806838-156806979
            571-687             JAXUCZ010000005.1  156807266-156807382
            688-753             JAXUCZ010000005.1  156813995-156814060
            754-830             JAXUCZ010000005.1  156814589-156814665
            831-943             JAXUCZ010000005.1  156815640-156815752
            944-1756            JAXUCZ010000005.1  156817811-156818623
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1756
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..102
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..933
                     /gene="Capzb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-actin-capping protein subunit beta; capZ beta; F-actin
                     capping protein beta subunit; capping protein (actin
                     filament) muscle Z-line, beta; capping actin protein of
                     muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta isoform 1"
                     /protein_id="NP_001423660.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVD
                     QPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANN
                     AFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKS
                     SGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE
                     DMENKIRSTLNEIYFGKTKDIVNGLRSLDAIPDNHKFKQLQRELSQVLTQRQVYIQPD
                     N"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     misc_feature    130..816
                     /gene="Capzb"
                     /note="F-actin capping protein, beta subunit; Region:
                     F_actin_cap_B; pfam01115"
                     /db_xref="CDD:460070"
     exon            103..192
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            193..314
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            315..428
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            429..570
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            571..687
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            688..753
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            754..830
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            831..943
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1756
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcactctt gggcacccgg ggaagtggaa gcgccgggcc ctgctgcggg ggggagagcc
       61 acagacgccg ggactgggac cgtcgccgcc gccgccacca tgagcgatca gcagctggac
      121 tgcgccttgg acctgatgag gcgcctgcct ccacagcaga ttgagaaaaa cctcagcgat
      181 ctgatcgacc tggtccccag tctgtgtgaa gatctcctgt cttctgttga ccagcccctg
      241 aaaattgcca gagacaaggt ggtgggcaag gactaccttt tgtgtgacta caacagagac
      301 ggggactcct ataggtcacc atggagtaac aagtatgacc ctcctttgga agatggggcc
      361 atgccatctg ctcggctcag aaagctggag gtagaggcca acaatgcctt cgaccaatac
      421 cgagacctgt attttgaagg tggtgtctca tcagtctacc tctgggatct cgatcatggc
      481 tttgctggag tgatcctcat aaagaaggct ggggatggat caaagaagat caaaggctgc
      541 tgggattcca tccacgtggt ggaagtgcag gagaagtcca gtggccgtac tgcccattac
      601 aagttgacct ccacagtgat gctatggctg caaaccaaca aatccggctc aggcaccatg
      661 aacctgggag gcagcctaac cagacagatg gagaaggacg aaactgtgag tgactgttcc
      721 ccacacatag ccaacattgg gcgcctggtg gaggacatgg aaaacaaaat cagaagcacg
      781 ctgaatgaga tctactttgg aaaaacaaag gacatcgtca acgggctgag atctcttgac
      841 gctatccccg acaaccacaa gtttaagcag ttgcagaggg aactttctca agtgctgacc
      901 cagcgccagg tctacatcca gcctgataat tgagccgacc caggtctgtg cagacgtttg
      961 cagacaaatc aaagcaggaa gcccttaaga atgacctggt ggaagccttg aagagaaagc
     1021 agcagtgtta aagacctgct tcacgctaac cggacacgcc atgcactcgt taggttcctt
     1081 tctttagaaa actcgttttc tgctcctttt ccctcttcct ttccctccct gacggtcaca
     1141 taacagtttg catcgaccac gcagcgccat ctctccccca aaataaagtc caataaccac
     1201 cctctggctc caaggcctgc ttcccacgac gtttccatag agaccgtgtg gctttgttcg
     1261 cctgtcccct tccttccctt gcccgtttgt aggcacaggc gcactgtctg acatcctccc
     1321 tccgtctttt tgttacattg gtgtaaaaaa tgtaaaacaa aaaaatttta tgaactaact
     1381 ggtgtgtgaa agaagggaaa ctggagctct gatccgtgtg tgtttggggg ttgcttggag
     1441 ccgggggccg ggggacaggg gacagctatg gaggaaggag acatgtcctc agcactgtcc
     1501 tgcgcagagc aggtgtgccc ttgtcccaag gagaccgcgg tgggggtggg ggcggggctg
     1561 gcgaccgctg ctctctggcc aggtgctttt ctgtcaaatt tttatggaat gcaaaaggag
     1621 ttttttgttt tattttgttt tttgtaaagc ttaaacagac aaaaaaaatc tacatcttct
     1681 acttgagcct ccatacttaa aaaaaaaaaa ggaaaaaaag aacaaaaaaa ataaataaaa
     1741 agaaactggg acacaa
//
LOCUS       NM_145767               2403 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus dorsal root ganglia homeobox (Drgx), transcript
            variant 2, mRNA.
ACCESSION   NM_145767
VERSION     NM_145767.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Ito,T., Sakai,A., Maruyama,M., Miyagawa,Y., Okada,T., Fukayama,H.
            and Suzuki,H.
  TITLE     Dorsal Root Ganglia Homeobox downregulation in primary sensory
            neurons contributes to neuropathic pain in rats
  JOURNAL   Mol Pain 16, 1744806920904462 (2020)
   PUBMED   32000573
  REMARK    GeneRIF: Dorsal Root Ganglia Homeobox downregulation in primary
            sensory neurons contributes to neuropathic pain in rats.
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   Rebelo,S., Chen,Z.F., Anderson,D.J. and Lima,D.
  TITLE     Involvement of DRG11 in the development of the primary afferent
            nociceptive system
  JOURNAL   Mol Cell Neurosci 33 (3), 236-246 (2006)
   PUBMED   16978876
REFERENCE   3  (bases 1 to 2403)
  AUTHORS   Ding,Y.Q., Yin,J., Kania,A., Zhao,Z.Q., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b controls the differentiation and migration of the superficial
            dorsal horn neurons of the spinal cord
  JOURNAL   Development 131 (15), 3693-3703 (2004)
   PUBMED   15229182
  REMARK    Erratum:[Development. 2009 Jun;136(11):1961]
REFERENCE   4  (bases 1 to 2403)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
REFERENCE   5  (bases 1 to 2403)
  AUTHORS   Ding,Y.Q., Yin,J., Xu,H.M., Jacquin,M.F. and Chen,Z.F.
  TITLE     Formation of whisker-related principal sensory nucleus-based
            lemniscal pathway requires a paired homeodomain transcription
            factor, Drg11
  JOURNAL   J Neurosci 23 (19), 7246-7254 (2003)
   PUBMED   12917357
REFERENCE   6  (bases 1 to 2403)
  AUTHORS   Chen,Z.F., Rebelo,S., White,F., Malmberg,A.B., Baba,H., Lima,D.,
            Woolf,C.J., Basbaum,A.I. and Anderson,D.J.
  TITLE     The paired homeodomain protein DRG11 is required for the projection
            of cutaneous sensory afferent fibers to the dorsal spinal cord
  JOURNAL   Neuron 31 (1), 59-73 (2001)
   PUBMED   11498051
REFERENCE   7  (bases 1 to 2403)
  AUTHORS   Saito,T., Greenwood,A., Sun,Q. and Anderson,D.J.
  TITLE     Identification by differential RT-PCR of a novel paired homeodomain
            protein specifically expressed in sensory neurons and a subset of
            their CNS targets
  JOURNAL   Mol Cell Neurosci 6 (3), 280-292 (1995)
   PUBMED   7496632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145767.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050747, SAMN17050756
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000016.1  7861157-7861349
            194-312             JAXUCZ010000016.1  7861578-7861696
            313-410             JAXUCZ010000016.1  7865563-7865660
            411-512             JAXUCZ010000016.1  7866794-7866895
            513-691             JAXUCZ010000016.1  7869636-7869814
            692-804             JAXUCZ010000016.1  7869900-7870012
            805-2403            JAXUCZ010000016.1  7889111-7890709
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2403
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="dorsal root ganglia homeobox"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
     exon            1..193
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    162..164
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="upstream in-frame stop codon"
     exon            194..312
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1070
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="homeobox protein DRG11; dorsal root ganglion 11;
                     paired-related homeobox protein-like 1; paired-like
                     homeodomain trancription factor Drg11"
                     /codon_start=1
                     /product="dorsal root ganglia homeobox protein"
                     /protein_id="NP_665710.2"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
                     /translation="MFYFHCPPQLEGTAPFGNHSTGDFDDGFLRRKQRRNRTTFTLQQ
                     LEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGA
                     KEPMAEVTPPPVRNINSPPPGDQARGKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLN
                     TATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVAALRMKAREHSE
                     AVLQSANLLPSTSSSPGPASKQVPPEGSQDKPSPTKEQSEGEKSV"
     misc_feature    378..548
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    378..548
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    540..683
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    879..932
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     misc_feature    879..932
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     misc_feature    888..929
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
     misc_feature    933..1067
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            313..410
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..512
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..691
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..804
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2403
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggtag gcagggttcc cgagccgctc tcccggctcc ctgctctggg ccttggggct
       61 ccaccggctt cttggcccga gctgctgcgc gtgcagatgg ccttgcgcga tcgccggacc
      121 ccgctgcggt ggccaagtgc agggcttgtg gctgggaccc ctgagaacca ggagccagac
      181 tgtgctcagc ttgccaggcc ggagccacgc acgggcacaa gtctgtcagg ccgccatcag
      241 tcctggtcca gccgtcaggg cccatccgac cgtcggcgat gttttatttc cactgcccgc
      301 cacagctaga gggcacagcg ccttttggta accactctac gggggatttt gatgatgggt
      361 ttcttagaag aaaacagcgc agaaatcgga caaccttcac tcttcagcag ttggaagctc
      421 tggaggcagt ctttgcccaa acacactacc cagatgtctt caccagagaa gagctagcca
      481 tgaaaataaa cctcacagaa gccagagtgc aggtttggtt ccagaaccga agagccaagt
      541 ggaggaagac agagagaggg gcctctgacc aggaaccagg ggctaaggaa cccatggcag
      601 aggtgacacc acccccagtg aggaacatca actctccacc cccaggggac caggcccggg
      661 gcaagaagga ggccctggag gcccagcaga gcctgggacg cacagtgggc cccgccgggc
      721 ctttcttccc ctcctgcttg ccagggaccc tcctgaacac agccacttat gcccaggccc
      781 tgtcccatgt ggcatctctg aaagggggcc cactgtgctc ttgctgcgtc ccagacccta
      841 tggggctctc cttcctcccc acttacggtt gccagagtaa ccgcacagcc agcgtggctg
      901 ccctgcgcat gaaggcccgc gagcattcag aagcggtcct gcagtctgcc aaccttctgc
      961 cgtccaccag cagcagcccc ggccctgcct ccaagcaggt gcctccagaa ggcagccagg
     1021 acaagccctc cccaacgaag gaacagagcg agggagagaa gagcgtatga gggtccggag
     1081 aacccagctg ggagccctgc ccacccctgc ttctctcagc ctcagccctg ccagcctctg
     1141 aaccacaagg agtagccacc tcctcatgga tctgacaggg caaacgggac ctgcaagctg
     1201 gttgagacct gaagagtccc tctagaattc tgctggtagg ctgtgttgtt ctcgcttttc
     1261 ctttggtgac attttccgat ggctcttagt gactctggac actgctctgt gatgaggtcc
     1321 ctgttttttg ctttttgttt tgtctctttt ttttttttgt tttgttttgt tttattttcc
     1381 aggccaagca gccttggagc aaagcagatt agtttattcc accatccttc ttgagatatc
     1441 tgggaaggtc ttgtcaattc caaggactgt ggcaaggatc atccgtgaaa gatgccaaga
     1501 agtgacatct catgacagga aatgagacgg gcactcccat attgcttaag aaccacagaa
     1561 ctggtggact atcagccagt tctcactccc ttcagccagg actggcatcg gcctcctttg
     1621 tcttgtttaa aggaattagc tgaggttttg gctaggaagt gacaagatat gggctgaaga
     1681 cattgtggtc ctgaccctag cagatctccc tgggcacatc tgacctggtc cagtcaggca
     1741 ggttgtcagt tcggggatgg gggctgctct gctgattctg tgtgtgggtt ccctgcaatt
     1801 agagtgttca cttgcaggcc ccgcctctct tcagaagagt gatgggaagt tcaccaatca
     1861 gaatgtagct ttgtggccca ggaaaggacc agagtccttg aagcggtagg aaatccctag
     1921 gaaggtccct taaatactta tgcccagatg agctgccctt cttcctatcc ccgtatgtcg
     1981 agaggttgac gagacaggaa agccaggaag atgactccgt gtggcagaag agaatggagt
     2041 ccaaagggcc aactttcaca gagatttctg ccgcagtcta gcgtggctgt gttctttcac
     2101 gcgatggtga cttcggagag atcagaggga gatgtgcaat agcatgagcc ccgctcctgg
     2161 cccgggtcct ggaaaggttg tggttgtttg gtggctttgg ctgataatgt ttccacgcaa
     2221 acagatattg ctttcatgat ggctgttctc atttcagttc tgataatcga gacgctgtgc
     2281 tcccaggcgc tctgcctccc cttaactctt caggagcacc ccctcccctg taatactcct
     2341 aagtgtatcg tgcctcactt acggttactg caacacattt gatggaacac actgtctcct
     2401 tta
//
LOCUS       NM_001436744            3014 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus dorsal root ganglia homeobox (Drgx), transcript
            variant 1, mRNA.
ACCESSION   NM_001436744 XM_063275063
VERSION     NM_001436744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Ito,T., Sakai,A., Maruyama,M., Miyagawa,Y., Okada,T., Fukayama,H.
            and Suzuki,H.
  TITLE     Dorsal Root Ganglia Homeobox downregulation in primary sensory
            neurons contributes to neuropathic pain in rats
  JOURNAL   Mol Pain 16, 1744806920904462 (2020)
   PUBMED   32000573
  REMARK    GeneRIF: Dorsal Root Ganglia Homeobox downregulation in primary
            sensory neurons contributes to neuropathic pain in rats.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Rebelo,S., Chen,Z.F., Anderson,D.J. and Lima,D.
  TITLE     Involvement of DRG11 in the development of the primary afferent
            nociceptive system
  JOURNAL   Mol Cell Neurosci 33 (3), 236-246 (2006)
   PUBMED   16978876
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Ding,Y.Q., Yin,J., Kania,A., Zhao,Z.Q., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b controls the differentiation and migration of the superficial
            dorsal horn neurons of the spinal cord
  JOURNAL   Development 131 (15), 3693-3703 (2004)
   PUBMED   15229182
  REMARK    Erratum:[Development. 2009 Jun;136(11):1961]
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Ding,Y.Q., Yin,J., Xu,H.M., Jacquin,M.F. and Chen,Z.F.
  TITLE     Formation of whisker-related principal sensory nucleus-based
            lemniscal pathway requires a paired homeodomain transcription
            factor, Drg11
  JOURNAL   J Neurosci 23 (19), 7246-7254 (2003)
   PUBMED   12917357
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Chen,Z.F., Rebelo,S., White,F., Malmberg,A.B., Baba,H., Lima,D.,
            Woolf,C.J., Basbaum,A.I. and Anderson,D.J.
  TITLE     The paired homeodomain protein DRG11 is required for the projection
            of cutaneous sensory afferent fibers to the dorsal spinal cord
  JOURNAL   Neuron 31 (1), 59-73 (2001)
   PUBMED   11498051
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Saito,T., Greenwood,A., Sun,Q. and Anderson,D.J.
  TITLE     Identification by differential RT-PCR of a novel paired homeodomain
            protein specifically expressed in sensory neurons and a subset of
            their CNS targets
  JOURNAL   Mol Cell Neurosci 6 (3), 280-292 (1995)
   PUBMED   7496632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced XM_063275063.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN17050747,
                              SAMN17050755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000016.1  7861008-7861162
            156-274             JAXUCZ010000016.1  7861578-7861696
            275-372             JAXUCZ010000016.1  7865563-7865660
            373-474             JAXUCZ010000016.1  7866794-7866895
            475-653             JAXUCZ010000016.1  7869636-7869814
            654-766             JAXUCZ010000016.1  7869900-7870012
            767-3014            JAXUCZ010000016.1  7889111-7891358
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3014
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="dorsal root ganglia homeobox"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
     exon            1..155
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    112..114
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="upstream in-frame stop codon"
     exon            156..274
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1032
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="homeobox protein DRG11; dorsal root ganglion 11;
                     paired-related homeobox protein-like 1; paired-like
                     homeodomain trancription factor Drg11"
                     /codon_start=1
                     /product="dorsal root ganglia homeobox protein"
                     /protein_id="NP_001423673.1"
                     /db_xref="GeneID:252880"
                     /db_xref="RGD:628616"
                     /translation="MFYFHCPPQLEGTAPFGNHSTGDFDDGFLRRKQRRNRTTFTLQQ
                     LEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGA
                     KEPMAEVTPPPVRNINSPPPGDQARGKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLN
                     TATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVAALRMKAREHSE
                     AVLQSANLLPSTSSSPGPASKQVPPEGSQDKPSPTKEQSEGEKSV"
     misc_feature    340..510
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    340..510
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    502..645
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    841..894
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     misc_feature    841..894
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     misc_feature    850..891
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
     misc_feature    895..1029
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62798.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            275..372
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..474
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..653
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..766
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..3014
                     /gene="Drgx"
                     /gene_synonym="Drg11; Prrxl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtagaca gacagcaaga catctggcca cttccccagt cacttctctg gtcctgcggg
       61 cgccagcagc gccaagcccc gcccgccgcc agccgagccc cgcgtgcgga ctagaggcga
      121 gcgcactccg gccttctcgt ccgcctcccg cagagccagg ccggagccac gcacgggcac
      181 aagtctgtca ggccgccatc agtcctggtc cagccgtcag ggcccatccg accgtcggcg
      241 atgttttatt tccactgccc gccacagcta gagggcacag cgccttttgg taaccactct
      301 acgggggatt ttgatgatgg gtttcttaga agaaaacagc gcagaaatcg gacaaccttc
      361 actcttcagc agttggaagc tctggaggca gtctttgccc aaacacacta cccagatgtc
      421 ttcaccagag aagagctagc catgaaaata aacctcacag aagccagagt gcaggtttgg
      481 ttccagaacc gaagagccaa gtggaggaag acagagagag gggcctctga ccaggaacca
      541 ggggctaagg aacccatggc agaggtgaca ccacccccag tgaggaacat caactctcca
      601 cccccagggg accaggcccg gggcaagaag gaggccctgg aggcccagca gagcctggga
      661 cgcacagtgg gccccgccgg gcctttcttc ccctcctgct tgccagggac cctcctgaac
      721 acagccactt atgcccaggc cctgtcccat gtggcatctc tgaaaggggg cccactgtgc
      781 tcttgctgcg tcccagaccc tatggggctc tccttcctcc ccacttacgg ttgccagagt
      841 aaccgcacag ccagcgtggc tgccctgcgc atgaaggccc gcgagcattc agaagcggtc
      901 ctgcagtctg ccaaccttct gccgtccacc agcagcagcc ccggccctgc ctccaagcag
      961 gtgcctccag aaggcagcca ggacaagccc tccccaacga aggaacagag cgagggagag
     1021 aagagcgtat gagggtccgg agaacccagc tgggagccct gcccacccct gcttctctca
     1081 gcctcagccc tgccagcctc tgaaccacaa ggagtagcca cctcctcatg gatctgacag
     1141 ggcaaacggg acctgcaagc tggttgagac ctgaagagtc cctctagaat tctgctggta
     1201 ggctgtgttg ttctcgcttt tcctttggtg acattttccg atggctctta gtgactctgg
     1261 acactgctct gtgatgaggt ccctgttttt tgctttttgt tttgtctctt tttttttttt
     1321 gttttgtttt gttttatttt ccaggccaag cagccttgga gcaaagcaga ttagtttatt
     1381 ccaccatcct tcttgagata tctgggaagg tcttgtcaat tccaaggact gtggcaagga
     1441 tcatccgtga aagatgccaa gaagtgacat ctcatgacag gaaatgagac gggcactccc
     1501 atattgctta agaaccacag aactggtgga ctatcagcca gttctcactc ccttcagcca
     1561 ggactggcat cggcctcctt tgtcttgttt aaaggaatta gctgaggttt tggctaggaa
     1621 gtgacaagat atgggctgaa gacattgtgg tcctgaccct agcagatctc cctgggcaca
     1681 tctgacctgg tccagtcagg caggttgtca gttcggggat gggggctgct ctgctgattc
     1741 tgtgtgtggg ttccctgcaa ttagagtgtt cacttgcagg ccccgcctct cttcagaaga
     1801 gtgatgggaa gttcaccaat cagaatgtag ctttgtggcc caggaaagga ccagagtcct
     1861 tgaagcggta ggaaatccct aggaaggtcc cttaaatact tatgcccaga tgagctgccc
     1921 ttcttcctat ccccgtatgt cgagaggttg acgagacagg aaagccagga agatgactcc
     1981 gtgtggcaga agagaatgga gtccaaaggg ccaactttca cagagatttc tgccgcagtc
     2041 tagcgtggct gtgttctttc acgcgatggt gacttcggag agatcagagg gagatgtgca
     2101 atagcatgag ccccgctcct ggcccgggtc ctggaaaggt tgtggttgtt tggtggcttt
     2161 ggctgataat gtttccacgc aaacagatat tgctttcatg atggctgttc tcatttcagt
     2221 tctgataatc gagacgctgt gctcccaggc gctctgcctc cccttaactc ttcaggagca
     2281 ccccctcccc tgtaatactc ctaagtgtat cgtgcctcac ttacggttac tgcaacacat
     2341 ttgatggaac acactgtctc ctttaaaaaa gaaaaaaaga aaaaaaaaaa agccagaccc
     2401 ccgttcttgc tgtattttgc ttgttgagta caaagatgaa gcgatttgcc aaaaagcggc
     2461 caagttgctc ccatttccct gtaattacga aggtttggtt gggcgatgta cgctccagcc
     2521 ctcatgcaca ctaactcttc aatctaattg tttgattaaa ctcgtatttc ctccagaaag
     2581 gtacataaat aagtgaactg ttgggcaaat taagaatact taacagcatt gcatccgaaa
     2641 agtagttatg ctgattaaat tttgtgtcct tgaggacttt caggaaatta cttttgatcg
     2701 tcaataacac aattaagtaa actacacaga cattagcatg aataattgat aagaaattat
     2761 gtattaccac gaagcactga tttaataatt catgacgcaa cactccagtg actgtgcaaa
     2821 actggataac attgaaaagt ctgcctgacg ttctggaaag aaaggaaaaa aaaaaaaaaa
     2881 aaaaagcaag agccaaacct ttgcagagat atctgagcac ttaagttctg ttgtacaaaa
     2941 gggcaaaagg taaccgatgc atgatgtcgt ttctgttcgt ataaacacct gaataaattt
     3001 agactttaaa gacc
//
LOCUS       NM_001436677            5737 bp    mRNA    linear   ROD 23-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 268 (Tmem268), transcript
            variant 1, mRNA.
ACCESSION   NM_001436677 XM_063287353
VERSION     NM_001436677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced XM_063287353.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.21924.1,
                                           SRR26360190.76421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2235              JAXUCZ010000005.1  81991410-81993644
            2236-2425           JAXUCZ010000005.1  81995120-81995309
            2426-2535           JAXUCZ010000005.1  81998175-81998284
            2536-2643           JAXUCZ010000005.1  82002470-82002577
            2644-2793           JAXUCZ010000005.1  82003984-82004133
            2794-2904           JAXUCZ010000005.1  82008206-82008316
            2905-2985           JAXUCZ010000005.1  82010409-82010489
            2986-3165           JAXUCZ010000005.1  82010883-82011062
            3166-5737           JAXUCZ010000005.1  82014399-82016970
FEATURES             Location/Qualifiers
     source          1..5737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5737
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
     exon            1..2235
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2425
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2290..2292
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="upstream in-frame stop codon"
     CDS             2317..3345
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="transmembrane protein C9orf91 homolog"
                     /codon_start=1
                     /product="transmembrane protein 268"
                     /protein_id="NP_001423606.1"
                     /db_xref="GeneID:298104"
                     /db_xref="RGD:1304595"
                     /translation="MACEPPSDPGGAAGPLPTSTLGCSTLPQGNPPGWGEELHNGQVL
                     SVLRIDNTCAPISFDLRVAEEQLQAWGIQVPAEQYRSLAESALLEPQVRRYIIYNSRP
                     MRLAFAVVFYVLVWANIYSTSQMFALGNQWAGVLLATLAAVSLTLTLVLVFERQQRKA
                     NTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEM
                     KRSQESLLRSRLSQLCVVMETGVSPVVERPEDLEDSPLLPRTPGPQERPLTQTELYQL
                     VPEAEPEEMARQLLAVFGGYYTRLLVTSQLPQPMGTRHMDSARIPCPCQLIEVHILGT
                     GCCPFLAR"
     misc_feature    2431..3300
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     misc_feature    2431..3300
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /note="Domain of unknown function (DUF4481); Region:
                     DUF4481; pfam14800"
                     /db_xref="CDD:464322"
     exon            2426..2535
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2643
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2793
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2904
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2985
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3165
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..5737
                     /gene="Tmem268"
                     /gene_synonym="RGD1304595"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgtcc ctccgctaag gctcgggtga tcttttcccg ccccacgcgt caggcgtggg
       61 atctgcaggg cagggcgggt gatttctggg gtgaaggaac cctaaggcca gagggcagag
      121 acccgggagc cagctgccta aggccgaggc caggtacggt gggagacgcc gggccgcgcg
      181 gcgccgagcc ggctttctgt tttggctccc tccgggtttt gctccctgac cttggatagt
      241 cagctttctc ttccggggct taatgttctc atcattgaaa tggggtgttt ggaccccttg
      301 tctagccagg tttttctgcc ctaaactttt ggggactgct gcttctctga tgtgttggac
      361 ttgcagtgtt attaacgaag ctgagaagaa ggaaagccgt ttttttcttt cctttcagga
      421 tgttaggcgc tcagttgttg gtgaggctgg caggcactat gcagagttag cacctctggg
      481 ggcttgagtc tgcacagacc gcgactggaa aatctggctg caaggcgggt tcccaaaggg
      541 actgtcagga gtctcagcag gcacttgctc cccctgggct ttgcttacct tcgtgtaggg
      601 ctccctgact tgtgtgctga agactggagc ggggctgagg ggggtggtaa atggttagca
      661 ttttcccttg ggggcctgcc tgcaccctct cagccttgta gcttcattgc tggatgagga
      721 tctacttggg gtgggggtgg ggctggaccc attctgacct ctggttcaaa tccatttagt
      781 tctgcatggc tcctttcagt ctcctccttg gttcagccta ggaacatcta gttcgtcctc
      841 tatcgaagtt gctcgccttt gctgcctggt ttcctcctca cctccctggc agttctctct
      901 cagtgcattt tccccagagg atggtgattc ctgaagggga gggctgagca aacgcttggt
      961 gttgtactcc tggttttaca gtccagggtc tgaccctaga ggcttctcag ggaacgtttg
     1021 cggttactgc cttcttgcag taatcaacct ttttctaagt gtgaatcttg tgaacatgga
     1081 accataggac aatcctaagt ttctgtcctt gtctcctctc taggaaacag aggcaaagga
     1141 gagtaccttg ctcaaggcca cccagatggg aagtagttgg gctgggcagg ttacttttag
     1201 ccaacacaca caaccttggg tgtgtggctc tgctgattgg ttctctgtgg gcagctgagg
     1261 gggctgatgt gggtgctgtg atttctgccc ccaacacaat gctgcttttg tgggattttg
     1321 caaccagtgg atccttctgt gcagcctcag gcttgagcaa ctccagcctg tgtcagctcc
     1381 tcccggcctt ttgaacactc cagtactgtg aggcttcact gagagggcct gagtcctccg
     1441 ccaggagtac agatgtcaag gttgtatctg cctggtggcc tagaagttga tcagaggcag
     1501 caggggagca caaccttgca tctgtttcac ggtttttgtg cctgttgggt gtatagaagg
     1561 aggaggtacg ataaagtagg ctggtaagta ctttgtttga gactgctgtt gtgaattggg
     1621 ctgaggacga ggagaccctg tcgtcccatt agaagtcttg caggctgact ggaatttgtt
     1681 tctgtatcat gtctaggaaa catgctttct tctgatccac tcaaaggtga tttcatgaat
     1741 tagctgcaag gaagccagac caggcccaca gatatgagag ctcgggtgct gtgggctgag
     1801 accctggagc cacatgctag aatcttctac aactctcctt ctactgatag ctttggaagg
     1861 agcatgtctt gaccataaac aggaaaacca tgttgaggaa agaacggaac ctgggctgtg
     1921 ggcagagtac tgaacaccag gggaacactg ccgttgtaga cactctggca ccaggggaac
     1981 actgccgttg tagacactcc tgcctcctca cctgcttttt ccatgggggc accttggggt
     2041 agaacttggg gaaccagggc ttgtgcagca agtgctttta cctgtggagt catccccctg
     2101 accccagatc cttctgttcc gaacaggaat ccccacactc ccactttgca ggtcatccca
     2161 gcctcgtgta actgctcctg ttgaagcctt gagctacaca gcgaagaggc cagaaggctc
     2221 agtgcctccc tgaaggcaag tggaggtgag acgctgcccg gtgtgaactg cacccctaga
     2281 aacaggaagt agaagctaga ccgctgtctg tctgccatgg cttgtgaacc tccctcagat
     2341 cctggtgggg cagctggtcc tctgcccacc tccaccctgg gctgcagcac cctgcctcag
     2401 gggaaccctc ctggctgggg ggaagagcta cacaatggcc aggtcctctc agtcctccgg
     2461 atcgacaaca cctgtgcacc catctccttt gacctgagag ttgcagaaga acagctgcag
     2521 gcctggggca ttcaggtccc tgctgagcag tataggagct tggctgagag tgcgcttttg
     2581 gagcctcaag tgaggaggta catcatctac aactccaggc ccatgaggct ggcctttgct
     2641 gtggtgttct atgtgttggt gtgggccaac atctactcca ccagccaaat gtttgcccta
     2701 ggcaaccagt gggcaggtgt gctgcttgcg accctggccg ctgtcagcct gaccctgact
     2761 cttgtgctgg tctttgagag gcagcagagg aaggctaaca ctaacacaga cctgaggctg
     2821 gtggctgcca atggagccct tctgagacac cgagtgctgc tgggggtgac agataccgtg
     2881 gagggatgcc agagtgtgat acagctctgg tttgtctact ttgacctgga gaactgtgtg
     2941 cagttcttgt ccgatcatgt ccaagaaatg aagaggagtc aggagtcctt gctgagaagc
     3001 agattaagcc agctatgtgt tgtcatggag actggagtga gccccgtggt ggaaaggcct
     3061 gaggacttgg aagattctcc cctcctgccc agaactcctg gtcctcagga gagaccactc
     3121 acacagactg aactctatca gcttgttcca gaggctgagc cagaggagat ggcccggcaa
     3181 ctgctggcag tgtttggtgg ctactacacc cggctcctgg tgacctctca gctccctcag
     3241 ccaatgggaa cacgacacat ggactctgca aggatcccat gcccctgcca gctcatagaa
     3301 gtacacattt tgggcacagg atgttgccca ttcctggcca ggtgacctag ggatgaaggt
     3361 gttcatcttc ctccaagact aagaagtagg ggaggagtca ggagcccagc atggccacca
     3421 gtgagctcag atgaggtcag cgtttggaga cactttctca agtgtcagtc atgtaggcct
     3481 ttgggtcatc aagtgcacac cagatgtctt cttggcatca tactctgtcc tggccttgct
     3541 gaatctggtg gctgagctgg tggctggcct tgcagcctgg atggaggata ctgtctgttg
     3601 cctgtcaagg cctagggacc tgcagctgac tccacagggc aagtgcctga ccctggggtc
     3661 agaaagtgag accaaggctc caaggagacg cccatctttc agcggtgcct cagtctgccg
     3721 gtcacaacct acctgccctc aatgtgaggg aagattcttg gaagggtgag ctagcttgtg
     3781 agtgacagta ccgtctggga ttgttgtctg ttagcaccaa ggttagagag ggctagggtt
     3841 ggaggatggg tgaggagaca aaagcctggc agatgaccat caacaagggg cactggaaaa
     3901 gaagctcctg ttatactcag tgactttgca ctggcttgct gcttgtgaat gtgtttctct
     3961 tctgccaagc agcagtggtg ttttctgaca ctaacattgt tctggaatga ggtatgatta
     4021 gacactctgg gtttatgtga agaactcagc gactttccca aagttggaag actgtctaca
     4081 gccctatgcc cagagccctg gactcgtgta aaggtcctgc tccatgaacc agcctttgtg
     4141 gtttttgtcc tccacaaatc atcattataa gttggaactc ttcctggaac tggctggcat
     4201 atgcattcat tcctgttgga ctcttattca tccttcaaaa ccctactttt catatccttc
     4261 ctgctgcttt ctgtctcact gaaattctga tggaactgcc ccccttatgg atgttttatg
     4321 ttattcagtg tttctcctgt acatacctct ttttctatca agactgtaaa ctcctcaagg
     4381 tccaacactg cacccacctt ccttttggga atgacttgga cttgtttaga aaaaaaaaac
     4441 aattttgaaa agtcccatgg attggtcgcc ttgccctctc cacccattgt ggcaaatgct
     4501 tctggaagac atggttgaat ggtaaggccc aggtcgtgat ggaccagagg tctggtctgc
     4561 agctgtgtca ctctatttgt gcaccctctg tttgcccatc tctacagctg gatgattttg
     4621 gtgatttcca gcttgtgctg tttgttattc ttacctccgt gcacaaagtg ctctcctgcc
     4681 cccaaactga ggggtccttg gtggggactg acctaaaata gtaacctgga ttcttgttgc
     4741 acacctgcca catccagggc tgcgtgacca tggctgagtg cactgcttct ctgtgtgtcc
     4801 aatgattcct ttatagattg atgcagtgaa ccacagtggc acagctcagg agattttctg
     4861 ggtgagacat gccctacttc cttgcattct ttgtgtccaa gatggaggag tcccccagcc
     4921 atgtgtcatg gcagctttgc tcagtgcagt tattcactgt cttttgagcc acagaaaatg
     4981 tcactgtgaa gttgatcaag ggaagcctgt gcttgtcctc tgttcacaga ctcttgagca
     5041 tgatggtgga aactaaaact gtttggtgag tgagagagtt gctcatggag gcttggtatg
     5101 gtccttccac agttttcctg cctgccggat gggacttatg gggtgagccc acagtagacc
     5161 ttctttgtgt gtgcctcggt ttcctcattt gtaaaatcca cgtgtctcac ctgcttcaca
     5221 aagtcgtcat gaggatgagc catccagcct tttttttttt tttttttttg aaaaaatatc
     5281 tttaatccta tccctgtgca ggtgaggtct gggagttaaa ctgaggtcct cagtaagagt
     5341 ggtttatgcc cttacttcag caccatctct acagccgagt gctcctaagt cttaaggctc
     5401 aatacccata agaggcagga accatggaca aaccgccatg caggtaggaa cagtcaaagc
     5461 caagtcctgc ctgccatctt gtctctgtcc cttcagacac cggggaggaa agcacatcct
     5521 ccagatgttt caacctgaat agcaacaacc ttcagtgctt gcaacaccaa agctgtcaca
     5581 aagccggagc aggaactcca taacctgtcg ccatttctca tttattcttg ttgtctggta
     5641 tacagtaggt gctcatatgt gtttgactct tgcctcatgc tcaattattc cagtacctca
     5701 gggttatgta tgcaaataaa gatttatcaa atctcaa
//
LOCUS       NM_001436764            5231 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 2
            (Lingo2), transcript variant 1, mRNA.
ACCESSION   NM_001436764 XM_063287591
VERSION     NM_001436764.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Loh,K.H., Stawski,P.S., Draycott,A.S., Udeshi,N.D., Lehrman,E.K.,
            Wilton,D.K., Svinkina,T., Deerinck,T.J., Ellisman,M.H., Stevens,B.,
            Carr,S.A. and Ting,A.Y.
  TITLE     Proteomic Analysis of Unbounded Cellular Compartments: Synaptic
            Clefts
  JOURNAL   Cell 166 (5), 1295-1307 (2016)
   PUBMED   27565350
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063287591.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840105
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               JAXUCZ010000005.1  56481186-56481842   c
            658-754             JAXUCZ010000005.1  56203865-56203961   c
            755-835             JAXUCZ010000005.1  55940273-55940353   c
            836-918             JAXUCZ010000005.1  55742987-55743069   c
            919-951             JAXUCZ010000005.1  55615058-55615090   c
            952-991             JAXUCZ010000005.1  55599598-55599637   c
            992-1151            JAXUCZ010000005.1  55528324-55528483   c
            1152-5231           JAXUCZ010000005.1  55166250-55170329   c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21-q22"
     gene            1..5231
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine rich repeat and Ig domain containing 2"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
     exon            1..657
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            658..754
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            755..835
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            836..918
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            919..951
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            952..991
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1151
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..5231
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1157..1159
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="upstream in-frame stop codon"
     CDS             1187..3007
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2
                     precursor"
                     /protein_id="NP_001423693.1"
                     /db_xref="GeneID:313156"
                     /db_xref="RGD:1310773"
                     /translation="MLHTAIPCWQPFLGLAMVLLFMGSTIGCPARCECSAQNKSVSCH
                     RRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFN
                     NLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV
                     GDNDLVYISHRAFSGLFSLEQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNINNMPV
                     YAFKRLFHLKQLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLT
                     HLNLSYNPISTIEAGMFSDLIRLQELHVVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE
                     TLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQATLQFGGQQPMCAGPDTIRERS
                     FKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRR
                     FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRF
                     LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVW
                     SRGKGKHKNSIDLEYVPRKNNGAVAEGEVAGPRRFNMKMI"
     sig_peptide     1187..1267
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    1265..1366
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    1265..1366
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    1301..1357
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1301..1357
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1328..>2206
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1328..>2206
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1361..1432
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1361..1432
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1433..1504
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1433..1504
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1505..1576
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1505..1576
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1577..1648
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1577..1648
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1649..1720
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1649..1720
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1721..1792
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1721..1792
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1793..1936
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1793..1936
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1937..2008
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1937..2008
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2009..2080
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2009..2080
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2081..2152
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2081..2152
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2153..2215
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2153..2215
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2165..>2359
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    2165..>2359
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    2417..2686
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    2417..2686
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    2468..2482
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    2468..2482
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    2507..2521
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    2507..2521
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    2582..2596
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    2582..2596
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    2624..2641
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    2624..2641
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    2663..2674
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    2663..2674
                     /gene="Lingo2"
                     /gene_synonym="RGD1310773"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
ORIGIN      
        1 gcaattcgcg cgctgagtgt ggccgccggg acccagcagc ccgccgcccg cccggtgtcc
       61 ctccttccca gctcctcagc cgcctcactg gagccttcct tccaccaccc attctttggc
      121 ttcgccgcct ccacttaaag tttccttggc gcagaggttt aggcgcaacg gctggagcca
      181 agacgctgtg gtggagggcg atcctcggcg tggctctgct gccagcacct gctccgcacc
      241 gaacccgcct gagcgcaggt ttttcttccc acttggcggg agcaggggga ggggtgcagt
      301 ggcgagaatc acagaggaac cccgtctcct gacggcatac acagcttggc tacccaacgc
      361 atttgtgggg tcacggaaga aagccggatc cgcagccaag ttgcctgagc ggggacaggg
      421 gaggtttcca aggccgccaa ggttgtttct gtctcagttg ccacaggcgt gagggtttgg
      481 agacgcttag actgccaggg ctttagaact gacattccct ccctgatccc tttgaaagga
      541 aaagctgaca gagctgaggc aggaggacgc ccgaaagaag ccccgggact cctgtgagct
      601 tcatcctcct tggctttgga ttttaaggac acgaaggggc atggacaaca tgtcaaggaa
      661 atctgctgct gatggtttca agatgtagaa tccttatatg tgaagtatcc caaatgaagt
      721 cttggaatct gcactgaaag tacttcatgt tgtggaactg gagagtgaca caggaagaca
      781 gcatcatgaa ctcttggggc ttctaatctt ctctgtggac ttttaaacac atgagcatag
      841 tgaaataatc ataaaaaaaa gaggatctga gatcaagagc acaggcagtc accagcatga
      901 ggagcccagt tcatcttgat gaagtgaaag aagcaaaatg cagtattcaa gggatttgaa
      961 gttcttgtca ttcagatctt tcacttgctt ggcatgtttc gagcagttgg ctggtgggat
     1021 tttgagagat gctgctgcct gtgacgtggt ggagttatca tgatcaacca ctcagttcgg
     1081 atttcaccca gtggccatga gctttgtctg acagacggca ggggttggat ctttaaaaag
     1141 gagcaaacca ggcccataac caaggtgtag aataaacagt ggagtcatgc ttcacacggc
     1201 tataccatgc tggcagccat tcctgggtct ggctatggtg ttactcttca tgggatccac
     1261 cattggctgt cctgctcgct gtgagtgctc tgcccagaac aaatctgtta gctgccacag
     1321 aagacgcttg atcgcgatcc ccgaaggcat tcccattgag accaaaatct tggacctgag
     1381 caaaaatcga ctaaagagca taaaccccga agaattcatc tcatatcctc tgttggagga
     1441 gatagacttg agcgacaaca tcatcgccaa tgtagaacct ggggcattta acaatctctt
     1501 taacctgcgt tccctccgcc taaaaggcaa tcgccttaag ttggtccctt tgggagtatt
     1561 cacgggactg tccaacctca ccaagcttga cattagtgag aataagattg tcattttgct
     1621 ggactacatg ttccaggatc tgcataacct gaagtctcta gaagtggggg acaatgattt
     1681 ggtttatata tcacacaggg ccttcagtgg actatttagc ttggagcagc tcaccctgga
     1741 gaagtgcaac ttgacagcgg taccaacaga agccctttcc catctccgca gcctcatcac
     1801 cctgcatctg aagcatctca atatcaacaa tatgcctgtg tatgccttta aaagattatt
     1861 ccacctgaaa caactagaga tcgactattg gccattgctg gatatgatgc cagccaatag
     1921 cctctatggt ctcaacctca catccctctc gatcactaac accaacctgt ccactgtccc
     1981 tttcctcgcc tttaaacacc ttgtatacct gacccacctt aacctctcct acaatcccat
     2041 cagcactatt gaagcaggca tgttctctga cctgatccgc ctacaggagc ttcatgtagt
     2101 cggggcccag ctccgcacca ttgaacctca ctccttccaa gggctccgct tcctccgcgt
     2161 gctcaatgta tctcagaacc tgctggaaac attggaagag aatgtcttct cttcccctag
     2221 ggctttggag gtcctgagca ttaacaataa cccactagcg tgcgactgcc gacttctctg
     2281 gctcctgcag cgacaggcca ccctgcagtt tggaggccag cagcccatgt gtgccgggcc
     2341 agacaccata cgtgagaggt catttaagga tttccatagc actgctcttt ctttttattt
     2401 tacctgcaaa aaacccaaaa tccgtgaaaa gaagttacag cacctcctag tggacgaagg
     2461 acagacggtc cagctggagt gcaacgcgga tggagacccc cagcccgtga tttcctgggt
     2521 gacacctcga aggcgtttta tcaccaccaa gtccaacgga agggccactg tgttgggtga
     2581 tggcacctta gaaatccgtt tcgcccagga tcaagacagt gggatgtatg tttgcatagc
     2641 tagcaatgct gctgggaatg acaccttcac ggcatctctc actgtgaagg gattcacttc
     2701 agaccgcttc ctttacgcaa acaggacccc tatgtacatg actgactcca atgacaccgt
     2761 ttccaacggc actaatgcca atactttttc cctggacctt aaaacaatac tggtatctac
     2821 agccatgggc tgtttcacat tcctgggagt ggttttattt tgttttctcc ttctttttgt
     2881 gtggagccga ggaaagggca aacacaaaaa cagcattgac cttgagtatg tgccccgaaa
     2941 aaacaatggt gctgttgcag aaggggaggt ggctggaccc aggaggttca acatgaaaat
     3001 gatataaggg cccaccacac acacactact actgtctctg tgttactgtt ggtaatgagt
     3061 aagacgtctg atatagcgag tccatcacaa ggtgatcagg cagcttcaca cagctgcccc
     3121 tgtgtcaaag cagggtccat ggaagctgga agacttctca tggacactgg ctgattagag
     3181 gcaggcaggc atgtgtcaga gcccttcaca cagtgggata ctaattgttt gcattgcaaa
     3241 tattggcatt ctggggatct cagtaatgac cctgaacctt tggctcatgc tgacggacaa
     3301 aaattcaaca ttttctacca ctgcaaaact aaaagaaaaa aaatttaaaa ggaacaacct
     3361 acagtgtagg atttacatat taaaaaaaga cacatttgtc taaaacatac tctacggtaa
     3421 aatttgtatt tattatcatt tgttaaaacc ttgcatcata caatactgtt ggttcagcac
     3481 caaaaaaaaa aaaaaaaaaa aaaagagaga tcaatatatt cttttttgaa acatatatgc
     3541 tgtatatgtt ttaaagcaat atgaatgaga ggttgtgctt ttagttactc accagtatag
     3601 atccaagtgt ggtctcactt tccttttatc cgcagagaaa cctgagaata gatccctgga
     3661 ataataggct gagatgtgtt gagatgtgta tgtctgatgt aggatgccaa gatacaagag
     3721 cccagtcaaa actgctcaac tctgttaact tctgttacta taaataaagg catgtgccta
     3781 gttttgatac agaatggaat attttttata tgtacactac caacctggac cagtttactg
     3841 taacagaagc ccttggtttc tccagaaggt ggtacgtctc tagatgtgcc tgtagaatgc
     3901 aaggtaggtg ccactcataa aagtgatcca tttagctact gcttagtttt acttttgcca
     3961 gtcactgcta aggggttaat gaccaatgga aaagagaata ttgatcatat agatttggca
     4021 atagtcgcca atgtctaatg tcaataattc tgttacccaa aagctctctg gataaagagg
     4081 tttcagaagt caataggaag cagggtgaga caagtgcgtc acagtagtga tcctgccaat
     4141 gatccttttc aaatgtgaca gctgctgaca gacggctaca gatcaaaggg aacacatagc
     4201 acatgacatc ccaattctat ccaatacaca gtagggccac gattaggcaa cttcaggata
     4261 tttccctgct tcctgatcaa gatttttagc ttcatattgg aaactatatt acatagataa
     4321 gaggaatttg ttttgtgtga agtagcaaaa gaaaaaccat tatagatcta aaaagcaatg
     4381 ttttgttcct tcactgggga agagttaagc ctatagttct acaaatatgt aatgctatgc
     4441 tgcttctttt accttcctga cctgagcata tttacccagt taagcagtta atgtcaccac
     4501 tccaaaacaa acaaacaaaa aaaaaaacag aaaaaaagga aaaaaggaaa gaaagataga
     4561 aaatagcatt attatcataa gtgacctggt taaaggaagc ataatttcat ttggctcagt
     4621 cctggataac tttcaaagca catatccata tggccagaaa aatattggat gcagactata
     4681 ttcttgaagt gacatgtatg taatcaatat aaagaaagtc tctatacttt tcacattttg
     4741 agaggatctt gaggaaggtc ttctttaggt tatattgtaa gatatgtaca aggattctgg
     4801 gatttcttcc ttttagtatt gtgggtctga ccctcaaaag cctagctttg ttaaatattt
     4861 gaaaatatga agaactttaa tactattaaa ttggccttta tttctaaaat ttttcataga
     4921 ctcttttgca aattgagtgt caatacttct aaacccattt atcctttgcc agtgggtagg
     4981 aactgagttg tagatttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta agattgaata
     5041 gttgcctgct ttgagttaga ttttattcaa ttatcatgac gattatcaca aatgttttac
     5101 aaatttaatt tacatttaaa gactaattca tttctagtaa tttgtatcaa cctcaactaa
     5161 actctatcaa aatttcaact cttgaaaaat taaatgcttt cttcttacaa taaagaaagt
     5221 taaagtggaa a
//
LOCUS       NM_001436826            1804 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus R-spondin 1 (Rspo1), transcript variant 1, mRNA.
ACCESSION   NM_001436826 XM_008764019
VERSION     NM_001436826.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Li,J.Y., Wu,X., Lee,A., Zhou,S.Y. and Owyang,C.
  TITLE     Altered R-spondin 1/CART neurocircuit in the hypothalamus
            contributes to hyperphagia in diabetes
  JOURNAL   J Neurophysiol 121 (3), 928-939 (2019)
   PUBMED   30649980
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Szenker-Ravi,E., Altunoglu,U., Leushacke,M., Bosso-Lefevre,C.,
            Khatoo,M., Thi Tran,H., Naert,T., Noelanders,R., Hajamohideen,A.,
            Beneteau,C., de Sousa,S.B., Karaman,B., Latypova,X., Basaran,S.,
            Yucel,E.B., Tan,T.T., Vlaminck,L., Nayak,S.S., Shukla,A.,
            Girisha,K.M., Le Caignec,C., Soshnikova,N., Uyguner,Z.O.,
            Vleminckx,K., Barker,N., Kayserili,H. and Reversade,B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. doi:
            10.1038/s41586-018-0296-7. PMID: 29977062]
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Li,J.Y., Chai,B., Zhang,W., Fritze,D.M., Zhang,C. and
            Mulholland,M.W.
  TITLE     LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food
            intake in the hypothalamus of male rats
  JOURNAL   Endocrinology 155 (2), 429-440 (2014)
   PUBMED   24280058
  REMARK    GeneRIF: These data indicate that Rspo1 and Rspo3 and their
            receptor LGR4 form novel circuits in the brain to regulate energy
            homeostasis.
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Niehrs,C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Ruffner,H., Sprunger,J., Charlat,O., Leighton-Davies,J.,
            Grosshans,B., Salathe,A., Zietzling,S., Beck,V., Therier,M.,
            Isken,A., Xie,Y., Zhang,Y., Hao,H., Shi,X., Liu,D., Song,Q.,
            Clay,I., Hintzen,G., Tchorz,J., Bouchez,L.C., Michaud,G., Finan,P.,
            Myer,V.E., Bouwmeester,T., Porter,J., Hild,M., Bassilana,F.,
            Parker,C.N. and Cong,F.
  TITLE     R-Spondin potentiates Wnt/beta-catenin signaling through orphan
            receptors LGR4 and LGR5
  JOURNAL   PLoS One 7 (7), e40976 (2012)
   PUBMED   22815884
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Carmon,K.S., Gong,X., Lin,Q., Thomas,A. and Liu,Q.
  TITLE     R-spondins function as ligands of the orphan receptors LGR4 and
            LGR5 to regulate Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11452-11457 (2011)
   PUBMED   21693646
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Kamata,T., Katsube,K., Michikawa,M., Yamada,M., Takada,S. and
            Mizusawa,H.
  TITLE     R-spondin, a novel gene with thrombospondin type 1 domain, was
            expressed in the dorsal neural tube and affected in Wnts mutants
  JOURNAL   Biochim Biophys Acta 1676 (1), 51-62 (2004)
   PUBMED   14732490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_008764019.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168963.1, SRR26643290.20365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  142536344-142536531
            189-533             JAXUCZ010000005.1  142540850-142541194
            534-725             JAXUCZ010000005.1  142553443-142553634
            726-875             JAXUCZ010000005.1  142555616-142555765
            876-1064            JAXUCZ010000005.1  142556063-142556251
            1065-1804           JAXUCZ010000005.1  142556872-142557611
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1804
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="R-spondin 1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
     exon            1..188
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            189..533
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    371..373
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="upstream in-frame stop codon"
     CDS             440..1228
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /codon_start=1
                     /product="R-spondin-1 precursor"
                     /protein_id="NP_001423755.1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
                     /translation="MRLGLCVVALVLSWTHLAVGSRGIKGKRQRRISAEGSQSCAKGC
                     ELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHC
                     EACFSHNFCTKCQEGLYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCS
                     KKRKLCGFRKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRRTPCPEGQKRKKASQG
                     RRENANRHPTRKNSKEPGSNSRRHKGQQQPQPGTAGPLTSVGPT"
     sig_peptide     440..499
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    563..865
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    563..865
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Furin-like repeat, cysteine-rich; Region:
                     Furin-like_2; pfam15913"
                     /db_xref="CDD:464939"
     misc_feature    881..1048
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    881..1048
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     exon            534..725
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            726..875
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1064
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1804
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccggg cggcggactg cggggcccgc gcgggccgcc ccagcaccaa tgcgccgggc
       61 ggggcgctgg cggccgagaa ggcattgagc aaccgggcag cgggcggagc gcggggccga
      121 cggcaacgcg ggacccaata gccgcgccgt cgcccctccg ggctgccccg ccacggccgc
      181 tgcgccaggt ctgtcttgag ggtggttctc tgctggcgtg agaagacttc tcatgtgacc
      241 ctctgaggtg gcttcaagca ggacaggacc tccctttgga ccgatggaga acctggctcc
      301 attccccctc agatcccagc tgaggttatg gtggatctgg cctgcagcct gggcctgggt
      361 cccctgccac tgacccagcc tcagagccta tagcaagaga ccacccctcc tgcaaggggc
      421 ccggggctgg ccagtgacta tgcggcttgg gctgtgtgtg gtggccctgg ttctgagctg
      481 gacacacctc gctgtgggca gccgggggat caagggcaag agacagaggc ggatcagtgc
      541 tgaggggagc caatcttgtg ccaagggctg tgagctctgt tcagaagtca acggttgcct
      601 caaatgctcg cccaagctct tcattctgct ggagaggaac gacatccgcc aggtgggcgt
      661 ctgcctgccg tcctgcccgc ctggatactt tgatgcccgc aaccccgaca tgaacaaatg
      721 catcaaatgc aagattgagc actgtgaggc ctgcttcagc cacaacttct gcaccaagtg
      781 tcaggagggc ttgtacttac acaagggccg ctgctatcca gcctgtcccg agggttccac
      841 agcagccaac agcaccatgg agtgcggcag tcctgcacaa tgtgaaatga gcgagtggtc
      901 accgtggggc ccctgctcca agaagaggaa gctgtgtggt ttccggaagg gatcggaaga
      961 gcggacacgc agggtgctcc atgctcctgg aggagaccaa accaactgct cagacaccaa
     1021 agagacccgg aagtgtaccg tgcgcaggac gccctgccct gaggggcaga agaggaagaa
     1081 ggcgagccag ggccggaggg agaatgccaa taggcacccg accaggaaga acagcaagga
     1141 gccaggctcc aactctcgga gacacaaagg ccagcagcag ccacagccag ggacagcagg
     1201 gccactcaca tcagtaggcc ccacctaggc acagtgacca gtctccagtt acgtgtggaa
     1261 gaatccagtg ctgtgagaac tttccagaac tggagcatct gggaaagaaa gtccacacat
     1321 accccattca cccacccatc catctatcca tgcatccatg cacacatatg gccacatctg
     1381 aaaacttcca cacacgcgcg cacacacaca cacacacaca cacacacaca cacacacaca
     1441 cacacacaca cacactcttg aggtcacaga agatatttcc attctgtggc ccagctgtat
     1501 attcagccta ggatgctctt agaaggcgta actgagagaa cctttcccag cacctgaagc
     1561 taaacttcaa tgcgtggaac cttctggagg aacttctggg acagcatctg ccagatggac
     1621 ggcagattgg aaccaaaact ggagcagctg ccgaggggaa gaatgctctc cctgtcctga
     1681 gaggcactcc cagcttcgag acttgattgt tggagaatca ttacacatcc ggggtgcacg
     1741 tcacggctga cctgacttgg aaactgcgta aaggtttatt tcaaattaaa aagagagaaa
     1801 caaa
//
LOCUS       NM_001436808            4579 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus lysine demethylase 4A (Kdm4a), transcript variant
            1, mRNA.
ACCESSION   NM_001436808 XM_017593391
VERSION     NM_001436808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4579)
  AUTHORS   Li,L., Ding,Z., Ma,F., Zhang,K., Lu,D., Wang,H. and Yang,K.
  TITLE     Spinal nerve transection-induced upregulation of KDM4A in the
            dorsal root ganglia contributes to the development and maintenance
            of neuropathic pain via promoting CCL2 expression in rats
  JOURNAL   Eur J Neurosci 60 (6), 5169-5188 (2024)
   PUBMED   39136140
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of KDM4A in
            the dorsal root ganglia contributes to the development and
            maintenance of neuropathic pain via promoting CCL2 expression in
            rats.
REFERENCE   2  (bases 1 to 4579)
  AUTHORS   Li,W., Zhang,Y., Lv,J., Zhang,Y., Bai,J., Zhen,L. and He,X.
  TITLE     MicroRNA-137-mediated lysine demethylase 4A regulates the recovery
            of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis
  JOURNAL   Int J Neurosci 133 (1), 37-50 (2023)
   PUBMED   33499717
  REMARK    GeneRIF: MicroRNA-137-mediated lysine demethylase 4A regulates the
            recovery of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis.
REFERENCE   3  (bases 1 to 4579)
  AUTHORS   Liu,Y., Zhao,L., Zhang,J., Lv,L., Han,K., Huang,C. and Xu,Z.
  TITLE     Histone Demethylase KDM4A Inhibition Represses Neuroinflammation
            and Improves Functional Recovery in Ischemic Stroke
  JOURNAL   Curr Pharm Des 27 (21), 2528-2536 (2021)
   PUBMED   33402077
  REMARK    GeneRIF: Histone Demethylase KDM4A Inhibition Represses
            Neuroinflammation and Improves Functional Recovery in Ischemic
            Stroke.
REFERENCE   4  (bases 1 to 4579)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   5  (bases 1 to 4579)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 4579)
  AUTHORS   Sohi,G., Marchand,K., Revesz,A., Arany,E. and Hardy,D.B.
  TITLE     Maternal protein restriction elevates cholesterol in adult rat
            offspring due to repressive changes in histone modifications at the
            cholesterol 7alpha-hydroxylase promoter
  JOURNAL   Mol Endocrinol 25 (5), 785-798 (2011)
   PUBMED   21372147
REFERENCE   7  (bases 1 to 4579)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 4579)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 4579)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
REFERENCE   10 (bases 1 to 4579)
  AUTHORS   Zhang,D., Yoon,H.G. and Wong,J.
  TITLE     JMJD2A is a novel N-CoR-interacting protein and is involved in
            repression of the human transcription factor achaete scute-like
            homologue 2 (ASCL2/Hash2)
  JOURNAL   Mol Cell Biol 25 (15), 6404-6414 (2005)
   PUBMED   16024779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017593391.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.20536.1,
                                           SRR26643298.28609.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000005.1  137004797-137004888 c
            93-274              JAXUCZ010000005.1  137002124-137002305 c
            275-450             JAXUCZ010000005.1  137000421-137000596 c
            451-565             JAXUCZ010000005.1  136994699-136994813 c
            566-759             JAXUCZ010000005.1  136993217-136993410 c
            760-809             JAXUCZ010000005.1  136991038-136991087 c
            810-913             JAXUCZ010000005.1  136989469-136989572 c
            914-1051            JAXUCZ010000005.1  136988994-136989131 c
            1052-1296           JAXUCZ010000005.1  136986918-136987162 c
            1297-1496           JAXUCZ010000005.1  136986178-136986377 c
            1497-1864           JAXUCZ010000005.1  136983358-136983725 c
            1865-1985           JAXUCZ010000005.1  136975431-136975551 c
            1986-2167           JAXUCZ010000005.1  136971303-136971484 c
            2168-2372           JAXUCZ010000005.1  136969629-136969833 c
            2373-2449           JAXUCZ010000005.1  136969129-136969205 c
            2450-2505           JAXUCZ010000005.1  136968639-136968694 c
            2506-2614           JAXUCZ010000005.1  136966908-136967016 c
            2615-2800           JAXUCZ010000005.1  136966445-136966630 c
            2801-2971           JAXUCZ010000005.1  136963305-136963475 c
            2972-3091           JAXUCZ010000005.1  136960072-136960191 c
            3092-3184           JAXUCZ010000005.1  136959687-136959779 c
            3185-4579           JAXUCZ010000005.1  136958178-136959572 c
FEATURES             Location/Qualifiers
     source          1..4579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4579
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="lysine demethylase 4A"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
     exon            1..92
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    83..85
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="upstream in-frame stop codon"
     exon            93..274
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3325
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /EC_number="1.14.11.-"
                     /note="isoform a is encoded by transcript variant 1;
                     lysine-specific demethylase 4A; jumonji domain containing
                     2A; lysine (K)-specific demethylase 4A"
                     /codon_start=1
                     /product="lysine-specific demethylase 4A isoform a"
                     /protein_id="NP_001423737.1"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
                     /translation="MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGL
                     AKVVPPKEWKPRTSYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIAN
                     SDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLV
                     EKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKR
                     LERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYH
                     AGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKA
                     GKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEECPEEDSEAAEQGEEGDVKRSLAKHR
                     IGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECQATLAPVRPTHSSVRQVEDSL
                     PFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAALDLSVNPESVEGRLVFSGSKKKAS
                     SSLGSSSSQDSVSSDSETTESVSCQGQEKTVLTVHSYSRGDGKAAPGEPSVKRQRSAP
                     RSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTP
                     EEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNELMAQQAPHCAVCMIFQTYHQVEFGG
                     FSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCS
                     VRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAV
                     AILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHV
                     SCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQ
                     CEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYG
                     AKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTE
                     KEVKQEKKRQRVINSRYREDYIEPALYRAIME"
     misc_feature    173..301
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Small domain found in the jumonji family of
                     transcription factors; Region: JmjN; smart00545"
                     /db_xref="CDD:128818"
     misc_feature    173..301
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Small domain found in the jumonji family of
                     transcription factors; Region: JmjN; smart00545"
                     /db_xref="CDD:128818"
     misc_feature    659..1009
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    659..1009
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
                     /db_xref="CDD:396791"
     misc_feature    2129..2428
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    2129..2428
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2A (JMJD2A); Region: PHD_JMJD2A; cd15575"
                     /db_xref="CDD:277050"
     misc_feature    order(2129..2131,2330..2344,2354..2356,2411..2413)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    order(2129..2131,2330..2344,2354..2356,2411..2413)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277050"
     misc_feature    2453..2782
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    2453..2782
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="Extended PHD finger (ePHD) found in Jumonji
                     domain-containing protein 2A (JMJD2A); Region:
                     ePHD_JMJD2A; cd15713"
                     /db_xref="CDD:277183"
     misc_feature    order(2615..2617,2657..2671,2687..2689,2765..2767)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    order(2615..2617,2657..2671,2687..2689,2765..2767)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277183"
     misc_feature    2825..2989
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    2825..2989
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt1; cd20463"
                     /db_xref="CDD:410534"
     misc_feature    order(2921..2926,2930..2941,2945..2947)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    order(2921..2926,2930..2941,2945..2947)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410534"
     misc_feature    2996..3163
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    2996..3163
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2A (JMJD2A) and similar
                     proteins; Region: Tudor_JMJD2A_rpt2; cd20466"
                     /db_xref="CDD:410537"
     misc_feature    order(3029..3037,3047..3049)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     misc_feature    order(3029..3037,3047..3049)
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410537"
     exon            275..450
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            451..565
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            566..759
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            760..809
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            810..913
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1051
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1296
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1496
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1864
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1985
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2167
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2372
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2449
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2505
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2614
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2800
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2971
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3091
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3184
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..4579
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttgtctt tcgccctcaa gaaagacagt gggatcggcg agtggcgaca gcaggaatcg
       61 agcctgagcc ctgctagggc tttaggctcc agggttttat ctgagcctca aaaaagaaga
      121 acaaaagaag aacaaaatgg cttctgaatc ggaaactttg aaccccagcg ctcggatcat
      181 gacgttttac cccaccatgg aagagtttcg aaacttcagc cgatacattg cctacattga
      241 atcccaagga gctcatcggg ctgggctagc caaggttgtt cctcccaaag aatggaagcc
      301 tcgaacctcc tatgatgaca tcgacgatct ggtcatccct gcacccatcc agcagctggt
      361 gactggccag tccggcctct tcactcagta caatatacag aagaaagcca tgactgttcg
      421 tgagttccgc aagatcgcca atagtgacaa gtactgtact ccacggtata gtgaatttga
      481 agaacttgag cgtaaatact ggaaaaacct cacattcaat cctcccatct atggagcaga
      541 tgtgaatggt actctctatg aacagcacgt tgatgagtgg aacatcggcc ggctgaagac
      601 catcctggac ctggtggaga aggagagtgg gatcaccatc gagggcgtga acacccccta
      661 cctgtacttt ggcatgtgga agacgtcctt tgcctggcac acggaagaca tggatctgta
      721 cagcatcaac tacctgcact ttggagagcc aaagtcttgg tactctgttc cacctgagca
      781 tgggaaacgc ctggagcggc tcgccaaagg ctttttccca ggaagtgctc aaagctgtga
      841 ggcttttctc cgccacaaga tgaccctgat ctccccatta atgctgaaga agtatggcat
      901 tccctttgac aaggtgaccc aagaagccgg ggagtttatg atcacttttc catatgggta
      961 ccatgctggt ttcaaccatg gcttcaactg tgcagagtct accaattttg ctacccgtcg
     1021 gtggattgaa tatggcaagc aggctgtact gtgttcctgc agaaaagata tggtgaagat
     1081 ctctatggac gtgtttgtca ggaggttcca gccggaacgc tacaaacttt ggaaagctgg
     1141 gaaagacagc actgttattg accacactct gcccacaccg gaagcagctg agtttctgaa
     1201 ggacagtgga ctaaccccaa gagctgggaa tgaggagtgc ccagaggagg actcggaagc
     1261 ggcggagcag ggagaggagg gggatgtgaa gagaagcctg gctaagcacc gaatagggac
     1321 aaagagacac cgagtctgtc tggaaatacc acaggaggtc agtcagagcg agctcttccc
     1381 caaggaagag ctgagttctg gacagtatga gatgacagag tgccaggcca ccctcgcccc
     1441 agtgaggccc acccacagct ccgtgcggca agttgaggac agccttccct tcccagatta
     1501 ctccgacccc actgaggtca aattcgaaga gctgaagaac gtcaaactag aagaggagga
     1561 tgaggatgag gagccggaag cagctgcact ggacctttct gtgaatcccg agtctgtaga
     1621 aggacgcctc gtcttctcgg gctccaaaaa gaaagcctcc tccagcctag gctccagttc
     1681 ctctcaggat tcagtttctt cagattccga aaccaccgag tctgtctctt gccagggcca
     1741 agagaaaaca gttctcacgg tgcacagcta ctccagagga gatggcaagg ctgccccagg
     1801 cgagccgagt gtgaagaggc agcgcagcgc cccccgcagc atcagcgagc aggagctggc
     1861 agaggttgca gatgagtaca tgctctccct ggaggagaat aagaagacca agggtcgccg
     1921 ccagcccttg agcaagctcc cacgccatca cccgctggtg ttgcaggagt gcggcagcga
     1981 tgacgagact tctgaacagc tgacacccga ggaagaggct gaggagaccg aggcttgggc
     2041 taagcctctg agccagctgt ggcagaaccg acctccaaac tttgaggctg aaaaggaatt
     2101 caatgagctc atggcccagc aggcccctca ctgtgctgtg tgtatgatct tccagaccta
     2161 ccatcaggtg gaatttggag gcttcagtca gagctgtggg aatgcttcag aaccagctgc
     2221 ccaacctcag aggactaagc cattgatccc cgaaatgtgc tttaccacaa ctggctgcag
     2281 cacagacatc aatctgtcca ccccttacct agaggaggat ggcaccagca tgctggtgtc
     2341 ttgtaagaag tgcagtgtcc gggtccacgc cagttgctat ggcgtccccc ctgcaaaggc
     2401 ttctgaagaa tggatgtgct ctcgatgttc agccaatgcc ctggaggaag actgctgttt
     2461 atgctcactg cgtggagggg ccctgcagag agcaaacgac gacagatggg ttcatgtttc
     2521 atgtgctgtg gcaattctag aagcaaggtt tgtcaacatt gctgaaagaa gtccagtgga
     2581 tgtgagcaaa atccctctgc cccgcttcaa actgaagtgt gtcttttgta agaagcgaag
     2641 aaaacggaat gctggctgtt gtgtgcagtg ctctcacggc cgctgcccca ctgccttcca
     2701 tgtgagctgt gcccaggctg ccggggtgat gatgcaaccc gatgactggc cttttgttgt
     2761 cttcatcacg tgcttccgcc acaagattcc caatttggag cgagctaagg gagccttgct
     2821 gagcatcacg gccggccaga aggtcatcag caagcacaag aacggccgct tctaccagtg
     2881 cgaggtggtc agactcacca ccgaaacctt ctacgaagtc aactttgatg acggctcctt
     2941 cagcgacaac ctttatcctg aggacatagt gagtcaggac tgtctccaac tggggcctcc
     3001 tgctgaaggc gaagtggttc aagtcagatg gacagatggt caagtctatg gggctaagtt
     3061 tgtggcctcc caccccatcc agatgtacca ggtggagttc gaggatggct cgcagctggt
     3121 ggttaagaga gatgatgtat acacactgga tgaagagctt cccaagagag tcaagtctag
     3181 actgtcagta gcttcagaca tgcggttcaa tgagattttc acagagaagg aagtaaagca
     3241 agaaaagaaa aggcaacggg tcatcaactc aaggtaccgg gaggattaca tcgagccagc
     3301 actgtatcgg gccatcatgg agtagacgtt tcccgggtct gagaggtccc agccatcaag
     3361 gcgagaacac tctcgggttc cacagcacag cagacacttg gaactcagaa gtcttagaaa
     3421 gagaagctgt acaaagaaaa ggaatgacat gtctgaccca tcaccttctc actcctcctt
     3481 caatgaattc tgccgtgaaa agacaagccg ggcgcttggc agcagctgac gctgacactg
     3541 ggatgctgtg actccatcag cgcccagtcc aaaccggtca gctgttcctg ctgggcggat
     3601 tgttgtttct tagcctagga ctagcttcct accacccacc tgcaccagca aggcagagag
     3661 gtgctggtgc tcaacccaat ccccttttgt atttatgtat gagtgtgtga gtgcacgcat
     3721 gtacaggtgt gtacctgtgt gagagcgctc gagtgtgcac ctgtgtgctt gagaatgtgt
     3781 gggtgtgcaa gcacgtgtgt gtgtgtgtgc gcgagtgcct gtgtgcatga gtgcatgagt
     3841 gtgtgtgtgg gagtgtgctt gatctggact agcttcagcc agcccctggg cttcactttc
     3901 tcctttgcct ctgcagggca aacaaaatgt gaaattctgc cctcagctaa gctgagtaag
     3961 ggccctgggg gatggctaga ggttggttgc catctgtccc ttcctggacc gatttcaaga
     4021 gagtgctggc aaagctgcag tattgggatg ctaaggagct gactgccacc tctgtccacc
     4081 cttggagtag aactcagagg ttctgtacta tgagcccaca aacttcaggc acggaagccc
     4141 ctgtggcagt gttagagggt gtgggtgggg cctaccttga agggagaatt ttaatgatgg
     4201 aaacaggcag agcctggtgg gtaatttttg tgcaggggaa aaaattgcag ttatgcaggg
     4261 gctatctgtg ggttaggatg aactggggcc actggaggcc aagggcaggt gtagccacgc
     4321 ccttggtcag gggtggggtg gggctgattg agggtggggg ggtgggactg gagggcaaca
     4381 ttgaaggggt taaacaggtt tttgctcctc ttgaatttgt ttgcctgggc ccaatattgg
     4441 agggcttcat accttgctct gtatacagga gtcagattta taatacttcc ccttttttgt
     4501 tacgtatgaa ctctataaac caaattattt tgaaaactgg tgcattacct tgtccttagc
     4561 aataaaatgt attgagcag
//
LOCUS       NM_001115023            2122 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus DEAD-box helicase 49 (Ddx49), transcript variant
            1, mRNA.
ACCESSION   NM_001115023
VERSION     NM_001115023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Awasthi,S., Verma,M., Mahesh,A., K Khan,M.I., Govindaraju,G.,
            Rajavelu,A., Chavali,P.L., Chavali,S. and Dhayalan,A.
  TITLE     DDX49 is an RNA helicase that affects translation by regulating
            mRNA export and the levels of pre-ribosomal RNA
  JOURNAL   Nucleic Acids Res 46 (12), 6304-6317 (2018)
   PUBMED   29618122
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced NM_001115023.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158855.1, SRR26643298.71041.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000016.1  19159349-19159493
            146-269             JAXUCZ010000016.1  19160495-19160618
            270-355             JAXUCZ010000016.1  19162513-19162598
            356-477             JAXUCZ010000016.1  19162681-19162802
            478-665             JAXUCZ010000016.1  19163352-19163539
            666-806             JAXUCZ010000016.1  19163622-19163762
            807-882             JAXUCZ010000016.1  19164230-19164305
            883-959             JAXUCZ010000016.1  19165054-19165130
            960-1057            JAXUCZ010000016.1  19165222-19165319
            1058-1132           JAXUCZ010000016.1  19165844-19165918
            1133-1221           JAXUCZ010000016.1  19166381-19166469
            1222-1293           JAXUCZ010000016.1  19166550-19166621
            1294-2122           JAXUCZ010000016.1  19166753-19167581
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2122
                     /gene="Ddx49"
                     /note="DEAD-box helicase 49"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
     exon            1..145
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Ddx49"
                     /note="upstream in-frame stop codon"
     CDS             31..1473
                     /gene="Ddx49"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ATP-dependent RNA helicase DDX49; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 49"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX49
                     isoform 1"
                     /protein_id="NP_001108495.2"
                     /db_xref="GeneID:290660"
                     /db_xref="RGD:1311124"
                     /translation="MAGFAELRLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLG
                     CAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDC
                     IIVGGMDMVTQALELSRKPHVVIATPGRLADHLRSSNTFNMKKIRFLVLDEADRLLEQ
                     GCTDFTADLETILSAVPARRQTLLFSATLTDTLKELQGLATNQPFFWEAQATVRTVEQ
                     LDQRYLLVPEKVKDAYLVHLVQTFQDQLEDCSIIIFTNTCKTCQILCMMLRKFNFPTV
                     ALHSMMKQKERFAALARFKSSTYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIH
                     RVGRTARAGRQGQAITLVTQYDIHLLHAIEEEIKQQLAELAVEEAQVLQILTQVNVVR
                     RECEIKLEASHFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQQNRRFKEKVEQT
                     LRQQKAGSTGRRSRPPRPRPQEPARAEAQN"
     misc_feature    31..1170
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     misc_feature    31..1170
                     /gene="Ddx49"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; Region: SrmB; COG0513"
                     /db_xref="CDD:440279"
     misc_feature    <1105..>1410
                     /gene="Ddx49"
                     /note="Spc7 kinetochore protein; Region: Spc7; smart00787"
                     /db_xref="CDD:197874"
     misc_feature    <1105..>1410
                     /gene="Ddx49"
                     /note="Spc7 kinetochore protein; Region: Spc7; smart00787"
                     /db_xref="CDD:197874"
     exon            146..269
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            270..355
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            356..477
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            478..665
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            666..806
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            807..882
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            883..959
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1057
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1132
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1221
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1293
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2122
                     /gene="Ddx49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accactaggt tctctacact agtctgaagc atggcggggt tcgctgagct ccggctatcg
       61 tcgtggctgg tggaacagtg tcgacagctg gggttgaagc agcccacgcc ggtgcagctc
      121 gggtgcatcc cggccatcct ggaaggtcgg gactgcttgg gttgtgcaaa aacaggaagt
      181 ggcaagacag cagcctttgt acttcccatc ctgcagaagc tgtctgagga cccttatggc
      241 atcttctgcc tggttttgac acccactaga gagctggcct accagatagc tgagcagttc
      301 cgagtgctgg ggaagcctct gggcctaaag gactgcatca tcgttggtgg catggacatg
      361 gtgactcagg ccctggagct ctctcggaag ccacacgtgg ttattgccac ccctgggcgc
      421 ctggctgacc acctgcgcag ttccaacact ttcaacatga agaaaatcag attcttggtg
      481 ttggacgagg ccgataggct gctggagcag ggttgcaccg acttcactgc agacctggag
      541 accatcctgt cagctgttcc agcacgcagg caaaccctcc tgttcagtgc cacactgaca
      601 gacacactca aggagctgca gggcctggct accaaccagc ccttcttttg ggaggcacag
      661 gccacggttc gcacggtgga gcagcttgac cagcgctatc tgctggtgcc tgagaaggtg
      721 aaggacgcct acctggttca cctggtccag accttccagg accagctgga ggactgctcc
      781 atcatcatct tcaccaatac ctgcaagacc tgccagatcc tttgtatgat gcttcgaaag
      841 ttcaacttcc ccacagtggc actgcactcc atgatgaagc agaaagagcg ctttgcagcc
      901 ctggccagat tcaagtccag cacctatcgg attcttattg ctactgacgt ggcctccaga
      961 ggcctggaca tccccactgt gcaggtggtc atcaaccaca acacccctgg gctccccaag
     1021 atctacatcc atagggtcgg tcgcacagcc cgtgcaggga ggcagggaca ggccatcaca
     1081 ctggtgacgc agtacgacat ccacctgttg catgccatcg aggaggagat caaacagcag
     1141 ctggctgaat tggcagtgga ggaggcccag gtcctgcaga tcctcacaca ggtcaacgtg
     1201 gtgcgcaggg agtgtgaaat caaactggag gcttcgcatt ttgatgaaaa gaaggagatc
     1261 aacaagcgga aacagatgat cctggagggg aaggacccgg acctggaggc caagcgcaaa
     1321 gctgagctgg ccaagattaa gcaacagaac cggcgcttca aggagaaagt ggagcagacg
     1381 cttcggcagc agaaagcagg gagcacaggc cggcggtcgc gtcctcccag acctcgtccc
     1441 caagagccag ccagggctga ggctcagaac tgagctgtaa acctactgca ggtggcccct
     1501 gacttcagta aatgctcttt gaacctgtca gtcagacttg aaaatggggc aggatgagtg
     1561 tagagccttc cggtcacagg accccaatgc ctctgttgcc ccatgaggat aaccggtgca
     1621 gccttccctc acagtgtccc tggggtgcaa ggcagcagca gccaaggaca gcaggtgtca
     1681 acaacgccac acgtagaaat gttacctggg cagaagcact gcccaaggat tctagaaaat
     1741 tctacacggt gcaaagctca gagacagctg gggccccctg gtccctgcca gggtgccttg
     1801 gggccgcagg cctccagagc aaactagggt gctgcctctg ccaggcgagc caggccctcg
     1861 cgcagctcgc tcagctcgaa cagccgcacg tccaacagct gcgcagcccg gcccacctct
     1921 gctcgtgcgc gctcccgctc ggcccgcgcc tcctccaggt tgctttccat cgcccgcagc
     1981 tgctgctcca gttctgcatt ccgggtctcc aggtcctgca gcgggaggca aggggtggga
     2041 caacctgtga agctttggtt gccagtcctc tctgatgcgg tctgtgtctt cacggggtca
     2101 gtaaaggacc acggaagtat ga
//
LOCUS       NM_001191612            3117 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger protein 362 (Zfp362), transcript
            variant 1, mRNA.
ACCESSION   NM_001191612 XM_006238922 XM_216345
VERSION     NM_001191612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 18, 2025 this sequence version replaced
            XM_006238922.4, NM_001191612.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.20499.1,
                                           SRR26643429.20918.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000005.1  146437569-146437882 c
            315-440             JAXUCZ010000005.1  146426100-146426225 c
            441-504             JAXUCZ010000005.1  146421491-146421554 c
            505-751             JAXUCZ010000005.1  146421103-146421349 c
            752-1079            JAXUCZ010000005.1  146417641-146417968 c
            1080-1304           JAXUCZ010000005.1  146416686-146416910 c
            1305-1383           JAXUCZ010000005.1  146407848-146407926 c
            1384-1542           JAXUCZ010000005.1  146407561-146407719 c
            1543-3117           JAXUCZ010000005.1  146403469-146405043 c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3117
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="zinc finger protein 362"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
     exon            1..314
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            315..440
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    397..399
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="upstream in-frame stop codon"
     CDS             403..1659
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 362 isoform a"
                     /protein_id="NP_001178541.1"
                     /db_xref="GeneID:297879"
                     /db_xref="RGD:1306498"
                     /translation="MSRSSPSGKGPSRMAEPRFNNPYFWPPPPTMPSQLDNLVLINKI
                     KEQLMAEKIRPPHLPPTSASSQQPLLVPPAPAESSQAVMSLPKLQQVPGLHPQSVPQP
                     DVALHARPATSTVTGLGLSSRTPAVSTSESTPGTGTGTSTPSTPTTTSQSRLIASSPT
                     LISGITSPPLLDSIKTIQGHGLLGPPKSERGRKKIKAENPGGPPVLVVPYPILASGET
                     AKEGKTYRCKVCPLTFFTKSEMQIHSKSHTEAKPHKCPHCSKSFANASYLAQHLRIHL
                     GVKPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHN
                     KDKPYKCPNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHT
                     VVEHLVSHHSPQRTESPGIPVRISLI"
     misc_feature    <481..>795
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <481..>795
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    1081..1143
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1081..1143
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1117..1194
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1117..1194
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1159..1227
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1159..1227
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1165..1227
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1165..1227
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1180..1182,1186..1188,1192..1194,1198..1203,
                     1210..1215,1222..1224,1264..1266,1270..1272,1282..1287,
                     1294..1299,1306..1308,1354..1356,1360..1362,1366..1368,
                     1372..1377,1384..1389,1396..1398)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1180..1182,1186..1188,1192..1194,1198..1203,
                     1210..1215,1222..1224,1264..1266,1270..1272,1282..1287,
                     1294..1299,1306..1308,1354..1356,1360..1362,1366..1368,
                     1372..1377,1384..1389,1396..1398)
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1201..1278
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1201..1278
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1249..1311
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1249..1311
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    <1315..1473
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    <1315..1473
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; Region: SFP1; COG5189"
                     /db_xref="CDD:227516"
     misc_feature    1333..1401
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1333..1401
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1423..1485
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1423..1485
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1519..1575
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1519..1575
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            441..504
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            505..751
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1079
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1304
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1383
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1542
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..3117
                     /gene="Zfp362"
                     /gene_synonym="RGD1306498"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactcgcc ggagccccgg ggccgggcgg gctgcgcagc cgagaggcgg ggggccggac
       61 gcggctcgct cgccgggccc agcgcaccgg ggccgcgcgg ctgcacagcc ggcctccgcc
      121 gccgcggcgc ctgcagaacc cagaagtgaa cagcaggcga cccggaaggt ttgcgcgccg
      181 ctccgcaccg agccccagcc gcgcgccgcc gctaccgccg ccgccgccga agccgggagc
      241 ccccagcccg gccctactcg ggccgccggg ctcggggctg cggccgcgtc ccggagcgcc
      301 gccagcactg ccaggtgccg ttgggaacac agaggaagtg actgactggg ggttcaggga
      361 aagctccgta gaagagggaa cacttgagct gggtcttgaa ggatgagtag aagttcacca
      421 agtgggaaag gaccctctag gatggccgaa cctcgattta acaacccata cttctggccc
      481 cctcctccca ccatgcccag ccagctggac aacctggtcc tgattaacaa gatcaaagag
      541 cagctgatgg ccgagaaaat ccggccgcct cacctgccac ccacctcagc ctcgtcacag
      601 cagccactgc tagtgccccc cgcgcccgcc gagagcagtc aggcggtcat gtcgctgccc
      661 aagctgcagc aggtgcccgg gctgcacccg cagtccgtgc cgcagcccga cgtggcgctg
      721 cacgcgaggc cggccaccag cactgtcaca ggtctggggc tttcctctcg gacccccgct
      781 gtgagtacat ctgagtcaac cccaggcacg ggcacaggca ccagtacccc atccacaccc
      841 accaccacca gccagagccg cctcatcgcc tcatccccca ccctcatctc agggatcacc
      901 agcccccccc tcctggactc catcaagaca atccagggcc acggcctgct tggccccccc
      961 aagtctgaac gcggccgcaa aaagatcaag gcagagaacc cagggggtcc ccctgtcctt
     1021 gttgtcccct accccatcct ggcctccggt gagaccgcca aggagggcaa gacatacagg
     1081 tgtaaggtat gcccgctcac ctttttcacc aagtctgaga tgcagatcca ctccaagtcg
     1141 cacaccgagg ccaagcccca caagtgccca cactgctcca agtcctttgc caatgcctcc
     1201 tacctggccc agcatctgcg catccacctg ggtgtcaagc cctaccactg ctcctactgt
     1261 gacaagtcct tccggcagct ctcccacctc cagcagcaca ccagaatcca cacaggcgac
     1321 agaccctaca agtgcccaca tcctggctgc gaaaaggctt tcactcaact ctccaacctc
     1381 cagtctcacc agcgtcagca caataaggac aagccctaca aatgtcccaa ctgctaccgg
     1441 gcctactcag actccgcctc cctccagatc cacctctccg cccatgccat caagcacgcc
     1501 aaggcctact gctgcagcat gtgcgggcgg gcctacacct cggagaccta cctgatgaag
     1561 cacatgtcca aacacacagt ggtggaacac ctggtgagcc atcactcacc ccagaggacc
     1621 gagtcccccg gcatcccggt gcgaatctct ctgatctgag cccacctgtg gtgccgcccc
     1681 gcccacttgg cagcacccag cctaactccc gctggggcct ccaggaacca ccaagctctc
     1741 tcacgaccta cccaacctgc cagaaagctt ggtccataga agccctgcct gatccggctc
     1801 ctgggcagcc aggccaactg caagattctg ggctgttctg gtggcatcca aagacgatct
     1861 cagagcactt tgaacctgtc tgtcgggttt tctttctttt tttttttttt ttttgttccc
     1921 cctccctcac ttgcttcact gtctcttgtt tttttttttt ttaaagtttg ttttggaaat
     1981 aacaaaaagg atatttattg gccagaatgt tggtgctgct aagaacgaga gattcaaagg
     2041 actggacgga cggatacaga gagaaccaga gggcagcgtg ggaacttctc tgaccacaac
     2101 ctcaggtctt gaggggaggc ctggggttct ggacttcaaa ggggactccc tccctcaggt
     2161 gggaagagac aggaggcagc tggagtgagc ccttcgtccc tgtcacccag tcaaactgcc
     2221 tgagctttgc cctagccctt gtgagcagcg ggtacagcag ctgccacctg cctggcttta
     2281 ggggatggaa aatgagagag gtctggagag ccgcgggacc aaagggtgca gtgacggctg
     2341 ggtggcgagc ccagggaatg ggctgggggt gtgccaggtg agacctggcc cctcccctgc
     2401 tgccctgaag accaccccag tctacctcgg tgctggccag gaaacctatc ggctacctct
     2461 cccaccactc cagactgtgg gcaaggggat ggagagggag ggggcctggg actaagtgcc
     2521 cttcccagaa tttcctccag aagggtacag tgcccaggga ggggttgtcc ttctctccac
     2581 ggatgagacg gggactcccc caacccagac cccaggccct gcggcaggga taggagcctc
     2641 tgaaggaggc cccaggagca gaccctgccc ccagcccccc aagacatatc ccaatccgaa
     2701 agccatgcgt gtccgtgtat ataggaacta tgtacagaac ccagagaagc ccccttccac
     2761 atcaccccca gagaagaaaa ctagacaaaa ctcatctata tattctgtat ctggagtccg
     2821 tttgaatatt aactgtgtta tttttataca ctttttaagc cttaactcgc cattgattta
     2881 ccagtttaac gtttcctggg gtttcttttc cactgggagg ggtctcagcc ccccacccac
     2941 cccaacccct tcgtttgact tgcgtcgtct gatactcagt attgtagctt tcgtccgcat
     3001 gttactaccc tgtaaatatg ctgttccaat accgttggca tcctttgctt ttttctatgg
     3061 gacctccagg ccaccatatt tagaaatagt taccttatta aaaaagagaa aacagtc
//
LOCUS       NM_001436794            1125 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus regulatory factor X-associated ankyrin-containing
            protein (Rfxank), transcript variant 1, mRNA.
ACCESSION   NM_001436794 XM_006252900
VERSION     NM_001436794.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Wiszniewski,W., Fondaneche,M.C., Louise-Plence,P.,
            Prochnicka-Chalufour,A., Selz,F., Picard,C., Le Deist,F.,
            Eliaou,J.F., Fischer,A. and Lisowska-Grospierre,B.
  TITLE     Novel mutations in the RFXANK gene: RFX complex containing
            in-vitro-generated RFXANK mutant binds the promoter without
            transactivating MHC II
  JOURNAL   Immunogenetics 54 (11), 747-755 (2003)
   PUBMED   12618906
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   Lin,J.H., Makris,A., McMahon,C., Bear,S.E., Patriotis,C.,
            Prasad,V.R., Brent,R., Golemis,E.A. and Tsichlis,P.N.
  TITLE     The ankyrin repeat-containing adaptor protein Tvl-1 is a novel
            substrate and regulator of Raf-1
  JOURNAL   J Biol Chem 274 (21), 14706-14715 (1999)
   PUBMED   10329666
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Masternak,K., Barras,E., Zufferey,M., Conrad,B., Corthals,G.,
            Aebersold,R., Sanchez,J.C., Hochstrasser,D.F., Mach,B. and Reith,W.
  TITLE     A gene encoding a novel RFX-associated transactivator is mutated in
            the majority of MHC class II deficiency patients
  JOURNAL   Nat Genet 20 (3), 273-277 (1998)
   PUBMED   9806546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006252900.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231410.1, SRR26643296.35371.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000016.1  19315505-19315709
            206-400             JAXUCZ010000016.1  19316487-19316681
            401-481             JAXUCZ010000016.1  19319936-19320016
            482-547             JAXUCZ010000016.1  19320608-19320673
            548-648             JAXUCZ010000016.1  19320847-19320947
            649-774             JAXUCZ010000016.1  19321077-19321202
            775-841             JAXUCZ010000016.1  19321578-19321644
            842-922             JAXUCZ010000016.1  19321972-19322052
            923-1125            JAXUCZ010000016.1  19322625-19322827
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1125
                     /gene="Rfxank"
                     /note="regulatory factor X-associated ankyrin-containing
                     protein"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
     exon            1..205
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    136..138
                     /gene="Rfxank"
                     /note="upstream in-frame stop codon"
     exon            206..400
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..993
                     /gene="Rfxank"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein RFXANK"
                     /codon_start=1
                     /product="DNA-binding protein RFXANK isoform 1"
                     /protein_id="NP_001423723.1"
                     /db_xref="GeneID:306353"
                     /db_xref="RGD:1311390"
                     /translation="MEPTQVAENLIPNQQSLAPDLEDPEDRRDESPDSSDTVVLSLFP
                     CTPDAVNPEADASASSLQGSFLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGEL
                     SQLKDHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAKERESAL
                     SLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE
                     ADSGYTPMDLAVALGYRKVQQVMESHILKLFQGTLGPADPE"
     misc_feature    <490..957
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <490..957
                     /gene="Rfxank"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    490..573
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    490..573
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(577..579,583..585,595..600,607..615,619..624,
                     634..636,643..645,670..672,676..678,682..684,694..699,
                     706..714,718..723,733..735,742..744,769..771,775..777,
                     781..783,793..798,805..813,817..822,832..834,841..843)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(577..579,583..585,595..600,607..615,619..624,
                     634..636,643..645,670..672,676..678,682..684,694..699,
                     706..714,718..723,733..735,742..744,769..771,775..777,
                     781..783,793..798,805..813,817..822,832..834,841..843)
                     /gene="Rfxank"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    577..672
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    577..672
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    676..771
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    676..771
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    775..861
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    775..861
                     /gene="Rfxank"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            401..481
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            482..547
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            548..648
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            649..774
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            775..841
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            842..922
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1125
                     /gene="Rfxank"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggaggag ttctcctgta ggaatagtcc tggcgtatta agttgctgct ctatgtccca
       61 gcagaagaag ctagaggact gggcgtccgg tcaccaactt gctcctcacg agatctactg
      121 gactagaaaa gtttgtgaac agagcttccc gagttttggg agagccaggc tggcagcgta
      181 agggaacgga ggaggctgga gggagcttcc tcgatggagc ccactcaggt tgcagagaac
      241 ctcatcccaa accagcagtc ccttgctcct gacctagagg atcctgagga ccgcagagat
      301 gaatccccag atagctctga cactgtcgtc ctcagtctgt tcccctgcac cccagacgct
      361 gtgaatcctg aggcagatgc cagtgcatcc tcactacagg gaagtttctt gaagcactcc
      421 acaaccctca caaaccggca acgtgggaat gaggtctcag ctctgccagc caccctggac
      481 tccctgtcta tccaccagct tgcagcccag ggggagctga gtcaactgaa ggatcacctg
      541 cgaaagggtg acaacctggt caacaagccg gatgaacgtg gcttcacccc cctcatctgg
      601 gcctcagcct ttggagaaat tgagacagta cgcttcctgc tagactgggg tgctgacccc
      661 cacatcctgg ccaaggagcg ggaaagcgct ctgtcgcttg ccagtatggg tggttacacg
      721 gacatcgtga ggttgctgct tgaccgtgat gtggacatca acatctatga ctggaatggg
      781 gggacaccac tgctctacgc tgtgcgtggg aaccatgtga agtgtgtgga ggccttactc
      841 gcccgaggtg ctgacctcac cacagaggcc gactctggct acaccccaat ggacctcgcc
      901 gtggccctag gataccgcaa agtgcaacag gtgatggaga gccacatcct caaactgttc
      961 cagggtaccc tggggcctgc ggacccggag tgaagacagc ctgttgggaa cccaggcact
     1021 cagggacaaa ccagtcagcc cacaactggc ttggaaggca gctcctggac agtggtggga
     1081 agagccctcc ccaacaggaa ccaataaatc tgtgcagaac ttgaa
//
LOCUS       NM_001107914            5443 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor B2 (Adgrb2),
            mRNA.
ACCESSION   NM_001107914 XM_001062170 XM_001062231 XM_001062290 XM_006238934
            XM_232778
VERSION     NM_001107914.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5443)
  AUTHORS   Purcell,R.H., Toro,C., Gahl,W.A. and Hall,R.A.
  TITLE     A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2)
            increases receptor signaling activity
  JOURNAL   Hum Mutat 38 (12), 1751-1760 (2017)
   PUBMED   28891236
REFERENCE   2  (bases 1 to 5443)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   3  (bases 1 to 5443)
  AUTHORS   Kee,H.J., Koh,J.T., Kim,M.Y., Ahn,K.Y., Kim,J.K., Bae,C.S.,
            Park,S.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in
            normal and ischemic brain: involvement of BAI2 in the
            ischemia-induced brain angiogenesis
  JOURNAL   J Cereb Blood Flow Metab 22 (9), 1054-1067 (2002)
   PUBMED   12218411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 20, 2025 this sequence version replaced
            XM_006238934.3, NM_001107914.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               JAXUCZ010000005.1  147608445-147608882
            439-1261            JAXUCZ010000005.1  147615512-147616334
            1262-1345           JAXUCZ010000005.1  147629319-147629402
            1346-1510           JAXUCZ010000005.1  147629687-147629851
            1511-1675           JAXUCZ010000005.1  147631073-147631237
            1676-1840           JAXUCZ010000005.1  147631868-147632032
            1841-2008           JAXUCZ010000005.1  147632124-147632291
            2009-2110           JAXUCZ010000005.1  147632371-147632472
            2111-2217           JAXUCZ010000005.1  147632745-147632851
            2218-2412           JAXUCZ010000005.1  147633689-147633883
            2413-2481           JAXUCZ010000005.1  147633963-147634031
            2482-2590           JAXUCZ010000005.1  147634120-147634228
            2591-2927           JAXUCZ010000005.1  147634518-147634854
            2928-3033           JAXUCZ010000005.1  147635567-147635672
            3034-3077           JAXUCZ010000005.1  147635768-147635811
            3078-3204           JAXUCZ010000005.1  147636028-147636154
            3205-3308           JAXUCZ010000005.1  147636484-147636587
            3309-3411           JAXUCZ010000005.1  147636687-147636789
            3412-3562           JAXUCZ010000005.1  147637668-147637818
            3563-3632           JAXUCZ010000005.1  147638001-147638070
            3633-3699           JAXUCZ010000005.1  147638468-147638534
            3700-3785           JAXUCZ010000005.1  147638698-147638783
            3786-3884           JAXUCZ010000005.1  147639081-147639179
            3885-4056           JAXUCZ010000005.1  147641211-147641382
            4057-4152           JAXUCZ010000005.1  147641663-147641758
            4153-4192           JAXUCZ010000005.1  147642042-147642081
            4193-4812           JAXUCZ010000005.1  147642749-147643368
            4813-4848           JAXUCZ010000005.1  147645258-147645293
            4849-4947           JAXUCZ010000005.1  147645618-147645716
            4948-5443           JAXUCZ010000005.1  147646235-147646730
FEATURES             Location/Qualifiers
     source          1..5443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5443
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="adhesion G protein-coupled receptor B2"
                     /db_xref="GeneID:313058"
                     /db_xref="RGD:1309431"
     exon            1..438
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    364..366
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="upstream in-frame stop codon"
     exon            439..1261
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..5136
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="brain-specific angiogenesis inhibitor 2"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B2
                     precursor"
                     /protein_id="NP_001101384.1"
                     /db_xref="GeneID:313058"
                     /db_xref="RGD:1309431"
                     /translation="MTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQD
                     LFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCTHFAPRLLPLDHYLVNFTCLRPGP
                     EEATARAESEVGRPEEEAEAEAAATGLELCGGSGPFTFLHFDKNFVQLCLSAEPSEAP
                     RLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGE
                     AGASPATTTPPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEE
                     PKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTL
                     CSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACE
                     GPELQTKLCSMAACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSVAGPAWATCAGAL
                     TDTRECSNFDCPATDGKWGPWNAWSLCSKTCDTGWQRRFRMCQASGTQGYPCEGTGEE
                     VKPCSEKRCPAFHEMCRDEYVMLMTWKRAAAGEIIYNKCPPNASGSASRRCLLSAQGV
                     AYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSG
                     DLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDSENKDKWDDAQQVSPGSV
                     HLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFPMRGRRGMKD
                     WVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGPAHQRLLPA
                     DPEESSSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELS
                     YIINGTTDPHCASWDYSRADASLGDWNTESCQTLETQAAHTRCQCQHLSTFAVLAQPP
                     KDLTLELAGAPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILAS
                     NILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKR
                     FLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIG
                     IIVFNKLMARDGVSDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMAS
                     LWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQD
                     VVKCQMGVCRTDESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITG
                     TLSRLSLDEDEEPKSCLVGPEGGLSFSPLPGNILVPMAASPGLGEPPPPQETNPVYMC
                     GEGGLRQLDLTWLRPSEPGSEGDYMVLPRRTLSLQPGGGGTGGEEAPRARPEGTPRRA
                     AKTVAHTEGYPSFLSVEHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSR
                     TMPRTVPGSTMKLGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQ
                     SSAKEKPSPPGGRPGLSQHRRHQSWSTFKSMTLGSLPPKPRERLALHRTAAWEPTEPP
                     DGDFQTEV"
     sig_peptide     454..513
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    529..1113
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Adhesion GPCR B N-terminal region; Region: AGRB_N;
                     pfam19188"
                     /db_xref="CDD:465991"
     misc_feature    529..1113
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Adhesion GPCR B N-terminal region; Region: AGRB_N;
                     pfam19188"
                     /db_xref="CDD:465991"
     misc_feature    1363..1509
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1363..1509
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1522..1674
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1522..1674
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1687..1839
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1687..1839
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1855..2007
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1855..2007
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    2014..2208
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Domain present in hormone receptors; Region: HormR;
                     smart00008"
                     /db_xref="CDD:214468"
     misc_feature    2014..2208
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="Domain present in hormone receptors; Region: HormR;
                     smart00008"
                     /db_xref="CDD:214468"
     misc_feature    2263..>2730
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="GPCR-Autoproteolysis INducing (GAIN) domain;
                     Region: GAIN; pfam16489"
                     /db_xref="CDD:465137"
     misc_feature    2263..>2730
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="GPCR-Autoproteolysis INducing (GAIN) domain;
                     Region: GAIN; pfam16489"
                     /db_xref="CDD:465137"
     misc_feature    3040..3201
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="G-protein-coupled receptor proteolytic site domain;
                     Region: GPS; smart00303"
                     /db_xref="CDD:197639"
     misc_feature    3040..3201
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="G-protein-coupled receptor proteolytic site domain;
                     Region: GPS; smart00303"
                     /db_xref="CDD:197639"
     misc_feature    3217..4089
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="brain-specific angiogenesis inhibitor 2, a group
                     VII adhesion GPCR, member of the class B2 family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmB2_BAI2; cd15988"
                     /db_xref="CDD:320654"
     misc_feature    3217..4089
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="brain-specific angiogenesis inhibitor 2, a group
                     VII adhesion GPCR, member of the class B2 family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmB2_BAI2; cd15988"
                     /db_xref="CDD:320654"
     misc_feature    3223..3300
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320654"
     misc_feature    3223..3300
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320654"
     misc_feature    order(3238..3240,3250..3252,3379..3381,3388..3393,
                     3400..3402,3421..3423,3442..3444,3658..3663,3667..3669,
                     3673..3675,3934..3936,3943..3945,3982..3984,3994..3996)
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]; other site"
                     /db_xref="CDD:320654"
     misc_feature    order(3238..3240,3250..3252,3379..3381,3388..3393,
                     3400..3402,3421..3423,3442..3444,3658..3663,3667..3669,
                     3673..3675,3934..3936,3943..3945,3982..3984,3994..3996)
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]; other site"
                     /db_xref="CDD:320654"
     misc_feature    3328..3396
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320654"
     misc_feature    3328..3396
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320654"
     misc_feature    3421..3507
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320654"
     misc_feature    3421..3507
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320654"
     misc_feature    3535..3597
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320654"
     misc_feature    3535..3597
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320654"
     misc_feature    3649..3738
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320654"
     misc_feature    3649..3738
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320654"
     misc_feature    3877..3960
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320654"
     misc_feature    3877..3960
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320654"
     misc_feature    3973..4050
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320654"
     misc_feature    3973..4050
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320654"
     exon            1262..1345
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1510
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1675
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1840
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2008
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2110
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2217
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2412
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2481
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2590
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2927
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3033
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3077
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3204
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3308
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3411
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3562
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3632
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3699
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3785
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3884
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..4056
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4152
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4192
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4812
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..4848
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..4947
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4948..5443
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcggcccg gcgcgcgctg cgggcagcgg ccggagcggc cggaggaatc cggttcggtg
       61 gcagcggcgg cgctgggagg cagagaggag gatgcggcac cggcgattag aggctggggc
      121 tgcggccgcc gcccgcgaat aggaggcggc gcgcggcgcg ggcggtgctc ggggcgggga
      181 gcggggggcg gcgcggcgag gaggcggcgg cggcggcagg agcccgcgcc cggcccggcg
      241 cccgcccgcc cgccccgtgc agctccgcgg cgcttgctct gcacccgccg ctcggcggag
      301 cgggagcctc gggcctcggc gcggctgcgg cgagctgccc tgcgcccggc ccggcccccg
      361 ccttagggat ggcaaacttg cgccccgcgg ccgcctccac cagcgccggc ccccgctcct
      421 gctgctgacg gcgcccaggg caagggacat aggatgaccc cagcctgtcc cctcttactg
      481 tctgtgattc tgtccctgcg cctggccacg gccttcgacc ctgcccccag tgcctgctct
      541 gccctggcct cgggcgtgct ctacggggcc ttctcactgc aggacctctt tcccaccatc
      601 gcctcgggct gctcctggac cctggagaac ccagacccca ccaagtactc gctctacctg
      661 cgcttcaacc gacaggagca ggtgtgcaca cactttgccc cgcgcctgct gcccctggac
      721 cactacctgg tcaactttac gtgtctgcgg cctggtccgg aggaagccac agcccgggcg
      781 gaatcagaag tggggcggcc agaggaggaa gcggaggccg aggcagcagc cacgggcttg
      841 gagctgtgtg gtggctcagg ccctttcacc tttctgcact tcgacaagaa cttcgtgcag
      901 ctgtgcctgt cggctgagcc ctcggaggcc ccacgtctgc tagcgcctgc tgccctggcc
      961 ttccgctttg tggaggtttt gcttatcaac aacaacaact ccagccagtt cacctgcggc
     1021 gtgctctgcc gctggagtga ggagtgtggt cgggctgcag gcagggcttg tggctttgct
     1081 cagccagggt gtagctgccc tggggaggct ggggccagcc ctgccaccac cacacctccg
     1141 gggcctccag ctgcccacac cctgtccaat gccttggtgc ctgggggccc agcccctcct
     1201 gctgaggccg acttgcactc ggggagcagc aatgacctgt tcaccaccga gatgagatac
     1261 ggtgaggagc cggaagagga accgaaggtg aaaacccagt ggccaaggtc tgcagatgag
     1321 cctgggctat acatggcgca gacaggcgac ccagcagctg aggagtggtc cccgtggagc
     1381 gtgtgttccc tgacgtgtgg gcagggtctg caggtgcgga cccgctcctg cgtgtcctcc
     1441 ccctatggga ccctgtgcag cgggcccctt cgggagaccc ggccttgcaa caattcagcc
     1501 acctgcccag tgcacggcgt gtgggaggag tgggggtcct ggagcctgtg ctcccgcagc
     1561 tgcgggcggg ggtcccggag tcggatgcgg acctgcgtgc ccccccagca cggcggcaag
     1621 gcctgcgagg gtcccgagct gcagactaaa ctctgcagta tggccgcctg cccggtggaa
     1681 ggccagtggc tagaatgggg tccctggggc ccatgctcct catcttgtgc caatgggacc
     1741 cagcagcgca gccggaagtg cagtgtggcc ggtccagcct gggccacgtg cgcaggtgcc
     1801 ctcaccgata cccgtgagtg cagcaacttc gactgtccag ccactgatgg caagtggggg
     1861 ccatggaacg catggagcct gtgctccaag acgtgtgaca cgggctggca acgccgcttc
     1921 cgcatgtgcc aggcttccgg cacgcagggc tacccttgcg agggcacggg agaggaggtg
     1981 aaaccctgca gtgagaagag gtgtccagcc ttccatgaga tgtgcagaga cgagtacgtc
     2041 atgctcatga cgtggaagag ggcagcggct ggcgagatca tttacaacaa atgtccccct
     2101 aatgcctcgg gttctgctag ccgccgctgt ctcctcagtg cccagggcgt ggcatactgg
     2161 ggactgccca gtttcgctcg ttgtatatct catgaatacc gatacctgta cctgtcactt
     2221 cgggagcacc tggctaaggg ccagcgcatg ctggcaggtg agggcatgtc gcaggtggtg
     2281 cggagcctac aggagctcct ggctcggcgt acttactaca gcggggacct gctcttctct
     2341 gtggacattc taaggaacgt cactgacacc ttcaagaggg ccacctatgt cccttccgct
     2401 gatgacgtgc agcgtttctt ccaggtggtg agctttatgg tggactcaga aaacaaggat
     2461 aagtgggacg acgctcagca ggtgtcgcct ggctctgtgc acttgctgcg tgttgtggaa
     2521 gatttcattc acctcgtggg cgacgctctc aaggccttcc agagctctct gattgtcacg
     2581 gacaacctgg tgatcagcat tcagagagag cctatctcag cggtgtccag tgacatcaca
     2641 tttcccatgc ggggccgcag gggcatgaag gactgggtac gacattcaga ggatcgcctc
     2701 ttcctaccca aggaggtgct cagcctgtcc tccccaggga agccagccac acctggggca
     2761 gccacagcgg gcagcccggg cagggggagg ggcccaggaa cggtgccccc tggcccaggc
     2821 cccgcccacc agcgccttct cccagctgac cccgaagagt cctcctccta ctttgtgatc
     2881 ggtgctgtgc tctaccgcac ccttggcctc atcctgccgc cccccaggcc tccacttgct
     2941 gtcacctccc gggtgatgac agtgactgtg cgtcccccca cccagcctcc agcggagccc
     3001 ctcattacag tagagctctc gtacatcatc aatggcacca ctgatcccca ctgtgccagc
     3061 tgggactact cgagagcaga tgccagcttg ggggactgga acactgagag ctgccagacc
     3121 ttggagaccc aagcagctca cacccgctgc cagtgccagc acctgtccac ctttgccgtc
     3181 ctggcccagc cacccaagga cctgactctg gagctggcgg gtgctccctc tgtccccctg
     3241 gtgatcggct gtgcggtgtc ctgcatggcc ctgctcacgt tgctggccat ctatgcagcc
     3301 ttctggaggt ttataaagtc agaacgctcc atcatcttgc tgaacttctg cctgtccatc
     3361 ctggcttcca acatcctgat cctcgtgggc cagtcccggg tgctgagcaa gggcgtatgc
     3421 accatgacag ctgccttcct acacttcttc tttctgtcct ccttttgctg ggtgcttaca
     3481 gaggcctggc aatcctatct ggctgtcatc gggcggatgc gcacccgcct ggttcgcaag
     3541 cgcttcctct gcctgggctg gggtctgcct gccctggtgg tggctgtgtc tgttggcttt
     3601 actcgcacca aaggatacgg cacatccagc tactgctggc tgtccctaga gggtggcctg
     3661 ctctacgcct ttgtgggtcc agcagcagtc atcgtcctgg tgaacatgct catcggaatc
     3721 atcgtcttca acaagctcat ggctcgagat ggcgtctcag acaagtctaa gaagcagagg
     3781 gccgggtcgg agcggtgccc ctgggccagc ctgctcctcc cctgctcagc gtgtggagcg
     3841 gtccccagcc ccctgctcag ctcagcctcg gccaggaatg ccatggcttc cctctggagt
     3901 tcctgcgtgg tactgcctct cctggcgctt acctggatgt ccgctgtcct ggccatgaca
     3961 gatcgccgct ccgtcctctt ccaggcgctc tttgctgttt tcaactctgc acaaggcttt
     4021 gtcatcaccg ccgtgcactg cttcctgcgc cgagaggtcc aggatgtggt aaagtgccag
     4081 atgggtgtgt gtcggactga tgagagtgaa gactccccag actcgtgcaa gaacggacag
     4141 ctgcagatcc tgtcagactt tgaaaaggac gtggatctgg cttgtcagac agttctgttc
     4201 aaggaggtca acacttgcaa cccgtccacc atcaccggca ctttgtcccg cctgtctctg
     4261 gatgaggatg aggagcccaa gtcctgtctc gtgggtcctg agggtggcct cagcttctca
     4321 ccactgcctg ggaacatcct agtacccatg gcagcctcgc caggtctggg ggagccacca
     4381 ccaccacagg agaccaaccc tgtgtacatg tgtggggagg gtggcctgcg gcaattggac
     4441 cttacatggc tacggccaag tgaaccaggc tctgaggggg actacatggt gctgccccgg
     4501 cggactttga gcctgcagcc tggcggtggg ggtacagggg gtgaggaggc accaagggcc
     4561 cggcctgagg ggaccccccg gcgggctgcc aagacagtgg cccacactga aggctacccc
     4621 agcttcttgt ctgtggagca ctcgggtcta gggctgggcc ctgcctatgg gtctctccag
     4681 aacccatatg ggatgacctt ccaaccacca ccaccaacac ccagcgcccg ccaagtacca
     4741 gagccaggag aacgtagccg gaccatgccc cgtacagtgc ctggttccac catgaagctg
     4801 ggctcccttg agcgaaagaa gcttcggtat tctgacttgg actttgagaa ggtgatgcat
     4861 acccggaaac ggcactcgga actctaccac gaactcaacc agaagttcca cactttcgac
     4921 cgctaccgta gccagtcctc agccaaggag aaacccagcc cccctggggg acgccctggc
     4981 ttgtcccagc acaggaggca tcaaagctgg agcactttca aatctatgac actgggctca
     5041 ctgcccccca aacctcgaga acggctggct ctgcaccgga cagcagcctg ggagcccaca
     5101 gaaccgccag acggcgactt ccagacagag gtgtgagtgc cacgccggac tgcccactgc
     5161 acagaaatat atatctattt tcacactcca ctttggaact accaggagcc agcgcccctc
     5221 cccctcccga ggctgggcag gaggtgcaga ggactcagcc tggctggggg cagccagact
     5281 ggcagggcct gggggccagg gcccctcctg gttctcagag gtcccttagc cactcaccag
     5341 agcctcatct ttgccccagc ctgtctgtcc ctgtcctggg ctggggaggg gggagggaaa
     5401 ctttgttggg aataaacttc actctgtgga tttgcctgct gaa
//
LOCUS       NM_001436819            1316 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger, MYND-type containing 12 (Zmynd12),
            transcript variant 1, mRNA.
ACCESSION   NM_001436819 XM_006238760
VERSION     NM_001436819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238760.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.485705.1,
                                           SRR26360181.3349888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000005.1  138312324-138312458
            136-277             JAXUCZ010000005.1  138324301-138324442
            278-449             JAXUCZ010000005.1  138327713-138327884
            450-619             JAXUCZ010000005.1  138333334-138333503
            620-742             JAXUCZ010000005.1  138336285-138336407
            743-854             JAXUCZ010000005.1  138339497-138339608
            855-1000            JAXUCZ010000005.1  138341575-138341720
            1001-1316           JAXUCZ010000005.1  138344954-138345269
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1316
                     /gene="Zmynd12"
                     /note="zinc finger, MYND-type containing 12"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
     exon            1..135
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1123
                     /gene="Zmynd12"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger MYND domain-containing protein 12; zinc finger,
                     MYND domain containing 12"
                     /codon_start=1
                     /product="zinc finger MYND domain-containing protein 12
                     isoform a"
                     /protein_id="NP_001423748.1"
                     /db_xref="GeneID:313552"
                     /db_xref="RGD:1307175"
                     /translation="MNVIYPLAVPKGRRLCCEVCEAPAERMCTACTVTYYCGPVHQKA
                     DWGSIHAKICQLLIPLRTSMPFFNSEEERQHGLQQLQRRQEHLIEFCYTVAQKYLFEG
                     RHEDAVPAALHSLRFRMNVHGLSSVELVPAYLLLAEASLGLGRIVQAEEYLSQAQWTV
                     LKSTDCSNATHSLLHRNLGLLYIAKKNLEEARYHLANDIYFASCAFGTEDVRTSGGYF
                     HLANIFYSLKKMELADTLYTKVSEIWYTYLSSHYQALLHARTQQTDLLGKQFMNDTGL
                     DEAQEAEAIRILTSILIIQESTSTQAPQKGILILKTLGILYYLMLEFSKAKEYATKAL
                     SLAEVYLSEEEQGVIQELLSAILAEEKQLTT"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    74..187
                     /gene="Zmynd12"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    254..>817
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    254..>817
                     /gene="Zmynd12"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; Region: Spy; COG3914"
                     /db_xref="CDD:443119"
     misc_feature    419..511
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    419..511
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(425..430,437..442,446..448,542..544,551..556,
                     563..568,572..577,668..670,677..682,689..694,701..703)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(425..430,437..442,446..448,542..544,551..556,
                     563..568,572..577,668..670,677..682,689..694,701..703)
                     /gene="Zmynd12"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    536..628
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    536..628
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    665..751
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    665..751
                     /gene="Zmynd12"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            136..277
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            278..449
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            450..619
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            620..742
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            743..854
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1000
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1316
                     /gene="Zmynd12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagactgac gccgctggcc acaccatgaa cgtgatctac ccgctggcgg tgcccaaggg
       61 gcgccggctc tgctgtgagg tgtgcgaagc cccggctgag cggatgtgca cggcctgtac
      121 agtcacttat tactgtggtc ctgtgcatca gaaggctgac tggggcagca tccatgcaaa
      181 gatatgccag ctgctgatcc ctctgcgcac cagcatgccc ttcttcaact cagaggagga
      241 gaggcagcat ggtctgcagc agctgcagag gcggcaggag cacttgattg aattctgcta
      301 cactgttgcc cagaaatatc tctttgaagg aagacatgaa gatgccgtcc ctgcagcttt
      361 gcactccctt cgcttccgca tgaatgtgca tggcctgagc tcagtcgagc ttgtgcctgc
      421 ttacctgctc ctggctgagg ccagccttgg tctgggccgg atagtgcagg ctgaagaata
      481 tctatcccaa gctcaatgga cagtcctcaa gtcaactgac tgtagtaacg ccacccactc
      541 tttactgcat cggaacctgg gccttctcta catagccaag aagaacctcg aggaagcccg
      601 gtaccatctg gctaatgata tttattttgc cagttgtgca tttgggacag aagacgtcag
      661 gacctcagga ggctacttcc acctggccaa cattttctat agccttaaga aaatggagct
      721 ggctgacaca ctgtatacaa aggtctcgga gatttggtac acatatctga gcagtcacta
      781 tcaagccctc ttgcatgctc gtacccaaca gacagattta ctgggcaaac agtttatgaa
      841 tgacaccggc ttggatgaag cccaggaagc agaagccatt cggatcctaa cttcaatcct
      901 gatcattcag gaatctactt ccactcaagc gccccaaaaa ggcatcctta ttcttaagac
      961 tctgggcata ctttactatc tgatgttgga gttttcaaag gcgaaggaat atgccacgaa
     1021 agccctcagt ctagctgagg tgtatctcag tgaggaggag caaggggtta ttcaagagtt
     1081 gctgagtgcc atcttggctg aggagaagca gctcacgacc tagaggccac cttgctggtg
     1141 ctgccgtggg ctgtgggctg tgggctgtgg gctgactagt ggtgcagagc tgctcacagg
     1201 tcctctggcc tgctcccacc cctccctggg gaccgcctga ggggctgtga tcctgtcagc
     1261 tggtgaccta gagctttggg cgcagtgttc aataaaattt gtttatcatg accttg
//
LOCUS       NM_001436783            3377 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 10, mRNA.
ACCESSION   NM_001436783 XM_039094342
VERSION     NM_001436783.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3377)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 3377)
  AUTHORS   Marino,S. and Nusse,R.
  TITLE     Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic
            lethal
  JOURNAL   PLoS One 2 (6), e519 (2007)
   PUBMED   17565372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3377)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_039094342.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.864705.1,
                                           SRR21887622.3468384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000016.1  19484023-19484218
            197-298             JAXUCZ010000016.1  19508790-19508891
            299-556             JAXUCZ010000016.1  19523772-19524029
            557-689             JAXUCZ010000016.1  19543122-19543254
            690-821             JAXUCZ010000016.1  19543358-19543489
            822-911             JAXUCZ010000016.1  19543675-19543764
            912-1043            JAXUCZ010000016.1  19544907-19545038
            1044-1208           JAXUCZ010000016.1  19545145-19545309
            1209-1488           JAXUCZ010000016.1  19546706-19546985
            1489-1790           JAXUCZ010000016.1  19548553-19548854
            1791-1865           JAXUCZ010000016.1  19549511-19549585
            1866-2058           JAXUCZ010000016.1  19549883-19550075
            2059-3377           JAXUCZ010000016.1  19551290-19552608
FEATURES             Location/Qualifiers
     source          1..3377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3377
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
     exon            1..196
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            197..298
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    258..260
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="upstream in-frame stop codon"
     exon            299..556
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2189
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="isoform 4 is encoded by transcript variant 10; p66
                     alpha; transcriptional repressor p66-alpha"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 4"
                     /protein_id="NP_001423712.1"
                     /db_xref="GeneID:290669"
                     /db_xref="RGD:1310596"
                     /translation="MSEEACRTRSQKRAFEPDLTEDDVESKKMKMERGPSELPVDGDS
                     RVMPEPSAGPAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASLKGTTVGSAQANSTPSSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAETAAPHPSLKQVIKPRRKLAFR
                     SGEARDWNNGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGRHSE
                     RVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQ
                     SATWK"
     misc_feature    696..815
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    696..815
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Coiled-coil and interaction region of P66A and P66B
                     with MBD2; Region: P66_CC; pfam16563"
                     /db_xref="CDD:465178"
     misc_feature    1545..1646
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     misc_feature    1545..1646
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     Region: ZnF_GATA; cl29608"
                     /db_xref="CDD:453031"
     exon            557..689
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            690..821
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            822..911
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1043
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1208
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1488
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1790
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1865
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2058
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..3377
                     /gene="Gatad2a"
                     /gene_synonym="RGD1310596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgccggcg ccgggctcca tgtgtgcggc cgaggggcgc attatctggc cggcggcgcg
       61 ggcgggcgga gcggcggagc gagcgccgcg ggcccgagcg gcccctcagg cgcagcgagc
      121 acgcgcggcc ggcgcccccc gcccccagcc ccgtggacac gcgcgctacc cctgggcccg
      181 gtcggcgcgc ggccgggttg gccagcacat tgagccagca catccacata agttgccttt
      241 tgacagagct gtggccatga cggcatggta ggaccagcgt cacggaccct gaggccagaa
      301 tgagtgaaga agcatgccga acccgcagtc agaagcgagc ctttgaacct gacctaacgg
      361 aggatgatgt ggagagcaag aaaatgaaaa tggagagagg accatcagaa ctgccggtgg
      421 atggagacag cagggtgatg ccagagccca gtgcaggccc agcccagggg ttgctgagga
      481 caacagaggc catgggcaca ggatctggcg aagggctgtt aggagacggg cctgtggaca
      541 tgcgtacctc acacagtgac atgaagtctg agaagagacc tccctcgcct gatgtgattg
      601 tgctctctga cagcgagcag ccatcaagcc cgagggtgaa tggcctgacc acagtggcct
      661 tgaaagacac cagcactgag gcgctcttga aaagcagccc agaagagcga gaacggatga
      721 tcaagcagct gaaggaggaa ttgaggctag aggaagcaaa gctggtcttg ttgaagaagc
      781 tgcgacagag tcaaatacag aaggaagcca ctgcccagaa gcctacagct tcctcaggga
      841 gcactgtgac cacccctccc ccactcgtgc ggggtcccca gaacattcct gctggcaagc
      901 catcactcca gacctcctcc actcggatac ccggcagcat catcccacca ccactggtcc
      961 gaggtgggca gcaggtgtct gccaaactgg gaccacaggc cagctctcaa gtagtcatgc
     1021 caccacttgt caggggagcc cagattcaca acatcagaca gcattcctcc acggggccac
     1081 cacccctcct cctggccccc cgtgcctcag tgcccagcat gcagattcag ggacagagga
     1141 tcatccagca gggactcatc cgggtcgcca atgtccccaa caccagtctg ctcgtcaata
     1201 tccctcagcc tacggcagcc tcactgaagg ggacaacagt tggctctgct caggcaaact
     1261 ccactcccag cagtgtggct tctgtggttg cctctgctga gtccccagct agccggcagg
     1321 ctgctgccaa gctagcgctg cgcaagcagt tggagaagac actgctggag atccccccac
     1381 ccaagccccc tgctccggag atgaacttct tgcccagtgc tgccaacaat gaattcatct
     1441 atctggtcgg cttggaggaa gtggtgcaga acctgctgga gacgcaagcg ggcaggattt
     1501 ctgccacctc agctgctgcc gtgttatccc gggagcctta catgtgtgtg cagtgtaaga
     1561 cagacttcac atgccgctgg cgagagaagg gtggagctgt catgtgtgag aactgcatga
     1621 catccaacca aaagaaggca ctaaaagtgg agcacaccag tcgcctgaag gccgccttcg
     1681 tgaaggcgct acaacaagag caggagatgg agcagcgact gctgcagcag ggcgtaggca
     1741 ccgccagcat caaggctgag accgcagctc cacatccctc gctgaagcag gtcataaagc
     1801 cccgacgtaa gttggcgttc cgctcaggag aggcccgtga ctggaataac gggtccgtac
     1861 tacagacttc cagccagctg tcccggggtt cagccacaac acctcgtggt gttctgcaca
     1921 ctttcagcca gtcacccaaa ctgcagaacg cagcctcagc tacggccctg gtaagcagga
     1981 ctggcagaca ttccgagaga gtcgtgggca ccagcaaggg caccgcctcc aactggaaaa
     2041 agacacctct gagcacaggt gggacgcttg ccttcgtcag cccaagcttg gcagtgcaca
     2101 agagctcctc ggccgtggac cgacagcgag agtacctcct ggacatgatt cctccacgct
     2161 ccatccccca gtcagccaca tggaaatagt gggagccggc ccagccgagg acaggccctc
     2221 tgctctcccg aggcccttgg tctaggacac gcagactacc ctcctagcaa gttgcctgag
     2281 acagctcagg ccttggctct tgccttgctg tggccaggag agtaccacca tggtgcccag
     2341 gatcagaacc agggaccttc cctatgggcc ttctccttcc tttttgcctt tagtttgccc
     2401 gacaccagca gaaactcgga ccttggggcc agctctgcct ggccagcgtg ggtgggagct
     2461 caccctggac actgtgacac acccgggcca gactggcacc gggggctccc gaagttgagc
     2521 cgggatttcg ttttcttttg gcttttccca tcttagctcc ccagtctctg cctcttcatg
     2581 gccatctata ggttgaagtt tgggttttat tgggtttttt gtttttgttt tttttataat
     2641 cacctcataa tgatgatgga attaaagtga actgcataga cccagggtca tggttgtgca
     2701 cagtgcagtc tggcaggctc taccccagag gatgctcaga gtggcagcag cagagatggc
     2761 aggtgccacc ctggctctgg tcgtgtttgt tgctgctcac tgcagtccct ggcttccaca
     2821 cttagcagaa tgaaccgcag cccagatctg tctgacatcc agaggctcca gagggatgct
     2881 ggggtccgcc atgctggagt cagagctgac tgctggctgg gaggctgctg ggttactttt
     2941 cgtggtttat tttattaaaa atttctatcc tttttctctt cattttgatg gacacaatct
     3001 caagatgccc atgcctgcca agaggcatcc aagtagggcc cagccagaac ccttaggtct
     3061 ggagtcagca gggcttactc cctcttagcc acagggatgt ctgaaagggc tgagtctact
     3121 tttgttctgt tttgtttcct tctccctcca ctcttaacaa tgggttccat ggtgaaaggc
     3181 agaagcagct ctgtgtccag cacgcacggt gcggccttct gctcatgtga ttggtcgccg
     3241 tcgtttcccc atccagccct ggtttccctt gacacaatac agttagggac tttaatttaa
     3301 acccttgttc tgcagaccat cgccctctgc agacatgccc ctgcctcctc ctaataaagg
     3361 ctcatttaac tccgtga
//
LOCUS       NM_001436791           10077 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus nuclear receptor binding SET domain protein 3
            (Nsd3), transcript variant 1, mRNA.
ACCESSION   NM_001436791 XM_006253307
VERSION     NM_001436791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10077)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   2  (bases 1 to 10077)
  AUTHORS   Rahman,S., Sowa,M.E., Ottinger,M., Smith,J.A., Shi,Y., Harper,J.W.
            and Howley,P.M.
  TITLE     The Brd4 extraterminal domain confers transcription activation
            independent of pTEFb by recruiting multiple proteins, including
            NSD3
  JOURNAL   Mol Cell Biol 31 (13), 2641-2652 (2011)
   PUBMED   21555454
REFERENCE   3  (bases 1 to 10077)
  AUTHORS   Kim,S.M., Kee,H.J., Eom,G.H., Choe,N.W., Kim,J.Y., Kim,Y.S.,
            Kim,S.K., Kook,H., Kook,H. and Seo,S.B.
  TITLE     Characterization of a novel WHSC1-associated SET domain protein
            with H3K4 and H3K27 methyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 345 (1), 318-323 (2006)
   PUBMED   16682010
REFERENCE   4  (bases 1 to 10077)
  AUTHORS   Rosati,R., La Starza,R., Veronese,A., Aventin,A., Schwienbacher,C.,
            Vallespi,T., Negrini,M., Martelli,M.F. and Mecucci,C.
  TITLE     NUP98 is fused to the NSD3 gene in acute myeloid leukemia
            associated with t(8;11)(p11.2;p15)
  JOURNAL   Blood 99 (10), 3857-3860 (2002)
   PUBMED   11986249
  REMARK    Erratum:[Blood 2002 Aug 15;100(4):1132]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006253307.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               JAXUCZ010000016.1  73166975-73167454   c
            481-1220            JAXUCZ010000016.1  73133777-73134516   c
            1221-1292           JAXUCZ010000016.1  73125115-73125186   c
            1293-1455           JAXUCZ010000016.1  73123928-73124090   c
            1456-1610           JAXUCZ010000016.1  73113202-73113356   c
            1611-2126           JAXUCZ010000016.1  73109120-73109635   c
            2127-2253           JAXUCZ010000016.1  73106339-73106465   c
            2254-2354           JAXUCZ010000016.1  73099673-73099773   c
            2355-2400           JAXUCZ010000016.1  73097292-73097337   c
            2401-2531           JAXUCZ010000016.1  73094278-73094408   c
            2532-2660           JAXUCZ010000016.1  73093182-73093310   c
            2661-2787           JAXUCZ010000016.1  73092433-73092559   c
            2788-2985           JAXUCZ010000016.1  73090215-73090412   c
            2986-3156           JAXUCZ010000016.1  73089594-73089764   c
            3157-3303           JAXUCZ010000016.1  73081993-73082139   c
            3304-3460           JAXUCZ010000016.1  73078771-73078927   c
            3461-3663           JAXUCZ010000016.1  73075315-73075517   c
            3664-3776           JAXUCZ010000016.1  73074628-73074740   c
            3777-4046           JAXUCZ010000016.1  73074003-73074272   c
            4047-4163           JAXUCZ010000016.1  73068735-73068851   c
            4164-4305           JAXUCZ010000016.1  73066716-73066857   c
            4306-4412           JAXUCZ010000016.1  73064878-73064984   c
            4413-4614           JAXUCZ010000016.1  73062820-73063021   c
            4615-10077          JAXUCZ010000016.1  73056751-73062213   c
FEATURES             Location/Qualifiers
     source          1..10077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..10077
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="nuclear receptor binding SET domain protein 3"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
     exon            1..480
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1220
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    504..506
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="upstream in-frame stop codon"
     CDS             525..4856
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase NSD3; Wolf-Hirschhorn
                     syndrome candidate 1-like 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD3 isoform
                     1"
                     /protein_id="NP_001423720.1"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
                     /translation="MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDG
                     GPTPFEATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGA
                     VRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEI
                     KLKITKTIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEER
                     KSHKVPKLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQ
                     VGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRV
                     REYKGHEQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREE
                     RVEQYTFIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQS
                     STDPRRQSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVV
                     KIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSA
                     SPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQVETSPQASLKTGLQ
                     KGASEISDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGPSDGQVGFGKQVDSPSAA
                     ADADASDAQSVDSSLSRRGVGLSKKDTVCQVCENTGDSLVACEGECCRHFHPECLGLA
                     AVPEGRFTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKG
                     FRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILICSN
                     HSKRSSHSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMI
                     PSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVW
                     VKLGNYRWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGRVFPYVEGD
                     TNFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKTSRKPPPYKHIKANKV
                     IGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVCPAGDRCQNQCF
                     TKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVT
                     NFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGM
                     ELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAADEKTKNAKLKKRRRGKA
                     EAKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECGS
                     AAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVSPEYWSKMRCKWESQD
                     GGEEVKE"
     misc_feature    1347..1736
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    1347..1736
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="first PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt1; cd20163"
                     /db_xref="CDD:438991"
     misc_feature    order(1386..1388,1395..1397,1479..1481)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1386..1388,1395..1397,1479..1481)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438991"
     misc_feature    1389..1400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    1389..1400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1590..1598,1605..1610)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     misc_feature    order(1590..1598,1605..1610)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438991"
     misc_feature    2652..2780
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 1 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD1_NSD3; cd15649"
                     /db_xref="CDD:277119"
     misc_feature    2652..2780
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 1 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD1_NSD3; cd15649"
                     /db_xref="CDD:277119"
     misc_feature    order(2652..2654,2682..2696,2709..2711,2763..2765)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277119"
     misc_feature    order(2652..2654,2682..2696,2709..2711,2763..2765)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277119"
     misc_feature    2796..2936
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 2 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD2_NSD3; cd15652"
                     /db_xref="CDD:277122"
     misc_feature    2796..2936
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 2 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD2_NSD3; cd15652"
                     /db_xref="CDD:277122"
     misc_feature    order(2796..2798,2826..2840,2856..2858,2919..2921)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277122"
     misc_feature    order(2796..2798,2826..2840,2856..2858,2919..2921)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277122"
     misc_feature    2937..3095
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger superfamily; Region: PHD_SF; cl22851"
                     /db_xref="CDD:473978"
     misc_feature    2937..3095
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger superfamily; Region: PHD_SF; cl22851"
                     /db_xref="CDD:473978"
     misc_feature    order(2937..2939,2991..3002,3012..3014,3078..3080)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="histone H3 binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:276966"
     misc_feature    order(2937..2939,2991..3002,3012..3014,3078..3080)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="histone H3 binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:276966"
     misc_feature    3294..3401
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 4 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD4_NSD3; cd15658"
                     /db_xref="CDD:277128"
     misc_feature    3294..3401
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 4 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD4_NSD3; cd15658"
                     /db_xref="CDD:277128"
     misc_feature    order(3309..3323,3333..3335,3384..3386)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277128"
     misc_feature    order(3309..3323,3333..3335,3384..3386)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277128"
     misc_feature    3420..3704
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="second PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt2; cd20166"
                     /db_xref="CDD:438994"
     misc_feature    3420..3704
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="second PWWP domain found in nuclear SET
                     domain-containing protein 3 (NSD3) and similar proteins;
                     Region: PWWP_NSD3_rpt2; cd20166"
                     /db_xref="CDD:438994"
     misc_feature    order(3456..3458,3465..3467,3549..3551)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438994"
     misc_feature    order(3456..3458,3465..3467,3549..3551)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438994"
     misc_feature    3459..3470
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438994"
     misc_feature    3459..3470
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438994"
     misc_feature    3855..3971
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="AWS domain; Region: AWS; pfam17907"
                     /db_xref="CDD:465559"
     misc_feature    3855..3971
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="AWS domain; Region: AWS; pfam17907"
                     /db_xref="CDD:465559"
     misc_feature    3975..4400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="SET domain (including post-SET domain) found in
                     nuclear receptor-binding SET domain-containing protein 3
                     (NSD3) and similar proteins; Region: SET_NSD3; cd19212"
                     /db_xref="CDD:380989"
     misc_feature    3975..4400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="SET domain (including post-SET domain) found in
                     nuclear receptor-binding SET domain-containing protein 3
                     (NSD3) and similar proteins; Region: SET_NSD3; cd19212"
                     /db_xref="CDD:380989"
     misc_feature    order(4008..4016,4065..4067,4095..4097,4107..4109,
                     4134..4154,4203..4217,4236..4244,4287..4289,4320..4352,
                     4356..4370,4395..4397)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative active site [active]"
                     /db_xref="CDD:380989"
     misc_feature    order(4008..4016,4065..4067,4095..4097,4107..4109,
                     4134..4154,4203..4217,4236..4244,4287..4289,4320..4352,
                     4356..4370,4395..4397)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative active site [active]"
                     /db_xref="CDD:380989"
     misc_feature    order(4008..4016,4134..4145,4203..4217,4326..4328,
                     4347..4349,4359..4370,4395..4397)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="SAM binding site; other site"
                     /db_xref="CDD:380989"
     misc_feature    order(4008..4016,4134..4145,4203..4217,4326..4328,
                     4347..4349,4359..4370,4395..4397)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="SAM binding site; other site"
                     /db_xref="CDD:380989"
     misc_feature    order(4065..4067,4095..4097,4107..4109,4140..4154,
                     4236..4244,4287..4289,4320..4334)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:380989"
     misc_feature    order(4065..4067,4095..4097,4107..4109,4140..4154,
                     4236..4244,4287..4289,4320..4334)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:380989"
     misc_feature    order(4221..4223,4362..4364,4368..4370,4383..4385)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:380989"
     misc_feature    order(4221..4223,4362..4364,4368..4370,4383..4385)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:380989"
     misc_feature    4509..4637
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 5 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD5_NSD3; cd15661"
                     /db_xref="CDD:277131"
     misc_feature    4509..4637
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="PHD finger 5 found in nuclear SET domain-containing
                     protein 3 (NSD3); Region: PHD5_NSD3; cd15661"
                     /db_xref="CDD:277131"
     misc_feature    order(4509..4511,4536..4550,4566..4568,4620..4622)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277131"
     misc_feature    order(4509..4511,4536..4550,4566..4568,4620..4622)
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277131"
     misc_feature    4632..4781
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="NSD Cys-His rich domain; Region: C5HCH; pfam17982"
                     /db_xref="CDD:465605"
     misc_feature    4632..4781
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="NSD Cys-His rich domain; Region: C5HCH; pfam17982"
                     /db_xref="CDD:465605"
     exon            1221..1292
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1455
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1610
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..2126
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2253
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2354
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2400
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2531
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2660
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2787
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2985
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3156
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3303
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3460
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3663
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3776
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..4046
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4163
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4164..4305
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4412
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4614
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4615..10077
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcggag gcggcggcgg cggcgacggc agcgggagct ggcggcgcgg agatccggac
       61 ggaggccgag gctggggctg ggtgccgggc gtctgggaaa ggtgtgcagc tttctatcgg
      121 agccccggga ccccgctgcc gtttggggcc gccaacctcc ggctcctctc aggcaccagc
      181 agctacgcgg cgacccccgt ccggccgcct ccccttcgct ccgcgtcgcc cgcagccttc
      241 cgtctgcccg caaacgagcc cggccggccg ggccgtggcc ctcctcagtg ccggccgcca
      301 tggcaggggt gctcggcgcg ggggaaatct agtccgagga tttcatgcgg cctagctcgg
      361 ttccgtctcc tgcgcccgcg gtcccggcag ctgccggcaa cccagcccca cttcgggcct
      421 ccgtgtctct cctgtgatcg tactgacacg gcaggggggt tagaatggaa caaactgaag
      481 gctcgatgag agaaagggaa agttaaggat gctggagcag aacaatggat ttctctttct
      541 ctttcatgca agggatcatg ggaaacacaa ttcagcaacc acctcaactc attgactcgg
      601 ccaatatccg ccaggaggat gcctttgata acaacagtga cattgttgaa gatggtggcc
      661 cgacaccctt cgaagctact ttgcaacaag gtttccaatg tccacctgca acagaagacc
      721 ttcctccact cacaaacggc tacccaccgt ccatcagctt gtatgagact caaaccaaat
      781 acccgccata tagccagtat cccaatgggt cagccaacgg ttttggtgca gttagaaact
      841 ttagtcctac tgactattac cattcagaaa ttccaaacac aagaccacat gaaattctgg
      901 aaaaaccgtc tcccccacag cctcctcctc ctcctcttct tcctcctcct cctcctccgg
      961 taccacaaac tgtgattcca aagaagacag gctcacccga gattaaacta aaaataacca
     1021 aaactatcca gaatggcagg gaattgtttg agtcctccct ctgtggagac cttttaaacg
     1081 aagtacaggc cagtgagcac ttaaagtcaa agcacgaaag cagaaaggaa aagaggaaaa
     1141 aaagcagcag acacgagtca tcgagatccg aagagcgaaa gtcacacaag gtccccaagt
     1201 tagagccaga ggggcagaat agaccaaatg agagggtgga ccctgcacca gaaaagccaa
     1261 gagaagagcc agtgctcaaa gaggccgtcc cggttcagcc aatactgtct tctgttccaa
     1321 caacagaaac gtccactggt gttaagttcc aggttggtga tcttgtttgg tccaaggtgg
     1381 gaacctatcc ttggtggcct tgtatggttt caagtgatcc ccagcttgag gtccatacca
     1441 aaattaacac aagaggtgcc cgggagtatc atgtccagtt ttttagcaac cagccagaga
     1501 gggcatgggt tcatgagaag cgggtacggg agtataaagg tcacgaacag tatgaagagt
     1561 tactagcaga ggcagccaaa caagccagca accattctga aaagcaaaag attcggaaac
     1621 cccgacctca gagagaacgc gcccagtggg atattggcat tgctcacgca gagaaagcat
     1681 tgcagatgac acgagaggaa agggtagaac agtacacgtt catctatatc gataagcagc
     1741 cagaagagtc tccgtcccaa gcaaagaaga gtgttacctc taaggcggaa gtcaagaaac
     1801 cccgaaggcc cagatctgtg gggaacagtc agccagaaca gaccagtgct ggggaggtgg
     1861 cttccccaca gtcgagtact gaccctcgca ggcagagcca gaggcggcac accagtgtgg
     1921 aagaggacgg gccgcctccc gttaaaatag cctggagaac agccgccgcc aggaagtcct
     1981 taccagcctc catcacaatg cacaagggga gcctagatct gcacaagtgt aatatgtctc
     2041 cagttgtgaa aattgaacaa gtgtttgctc tccagaatgc aacaggagat gggaagttta
     2101 ttgatcagtt tgtttattca acgaagggaa ttggtaacaa aacagaaata agtgtcaggg
     2161 ggcaagacag gcttataatc tcttcaccaa gtcagagaaa cgagaagtcg actccgagcg
     2221 cgtcacctcc ggaggccaca tctggttctg caggcccagt agaaaagaag cagcagagaa
     2281 gatcaatcag gactcgatct gagtcagaga aatccaccga ggttgtgtca aagaagaaga
     2341 tcaaaaagga gcaggttgaa acatctcctc aggcttccct gaagaccgga ttacagaaag
     2401 gtgccagcga gatttcagat tcctgtaaac ctctaaagaa aaggagtcgc gcctcgactg
     2461 atgtggaaac ggccagttgc acgtacagag acacatctga ctccgattcc agaggaccga
     2521 gtgatgggca ggtaggcttt ggaaaacaag tagatagccc gtcagcagct gctgatgcag
     2581 atgcttctga tgcacagtcg gtggactcga gcctgtcacg gagaggcgtc ggcctgagta
     2641 agaaggacac tgtgtgtcag gtctgtgaga acactggaga ctctctcgtt gcttgtgagg
     2701 gggaatgctg cagacacttt catccggagt gcttggggct ggctgcggtc cctgagggac
     2761 gcttcacctg tgaggagtgt gagacagggc agcacccatg tttttcatgt aaagtgtctg
     2821 gtaaggatgt gaaacgttgt tctgttagtg tttgtggaaa gttttatcat gaagcctgtg
     2881 tccgcaaatt ccccactgcc atctttgagt caaaaggatt ccgctgtccc cagcactgtt
     2941 gttcttcctg ctccatggag aaggacatcc acaaagcgag caaaggccgg atgatgaagt
     3001 gcttgagatg cccaatcgcc taccactttg gagatgcgtg tgtcgctgct ggaagtgtat
     3061 ctgtgtcctc ccacattctc atctgtagta accattccaa gcggagtagt cattctgctg
     3121 ctataaacgt aggcttttgt ttcgtttgtg ccagagggct gatagttcag gaccattcag
     3181 accccatgtt cagttcctat gcctataaat cccactacct actgagtgaa tcaaaccgtg
     3241 ctgagttgat gaaattacct atgattcctt cttcgtcagc ttccaaaaag agatgtgaga
     3301 aaggtggaag attgctctgc tgtgaatcgt gccctgcttc cttccaccca gaatgcctga
     3361 gcatagacat gcccgaaggc tgctggaatt gcaatgactg taaagctggc aagaagctgc
     3421 attacaaaca gattgtttgg gtcaaattgg gaaattacag atggtggcct gcagagacct
     3481 gcagtcccag gtctgtgccg ctgaacatcc agggccttaa gcacggcgtg ggcgacttcc
     3541 ctgtgctctt ctttggctct catgactact actgggtcca ccaaggcaga gtgtttccct
     3601 atgttgaagg agacacaaac tttgctgagg gacagactag cattaacaag accttcaaaa
     3661 aagcactgga agaagctgca aaacgtttcc aggagttgaa agcgcagcga gagagtaagg
     3721 aggctttgga gatagagaaa acctcaagaa aaccccctcc ctacaaacac atcaaggcca
     3781 acaaagtcat agggaaggtg cagatccagg tggctgacct gtcggagatc ccgcgctgta
     3841 actgcaagcc tggtgatgaa aacccatgtg gcctggagtc ggagtgtcta aacagaatgt
     3901 cacagtacga gtgtcacccg caggtgtgcc ctgctgggga ccgctgtcag aaccagtgct
     3961 ttacaaagag gctgtacccc gatgcagaga tcatcaaaac tgagcggaga ggatggggcc
     4021 tcagaaccaa aagaagtatt aaaaaggggg aatttgtaaa cgaatatgtc ggtgaactaa
     4081 tcgacgagga agagtgcaga cttcgaatca agcgagccca cgagaacagt gtaactaatt
     4141 tttatatgtt aactgttacc aaggaccgta taattgatgc tggaccaaag ggaaattatt
     4201 ctcgtttcat gaaccacagt tgtaatccaa actgtgagac acagaagtgg accgtgaatg
     4261 gagatgtccg agtcgggctg ttcgctcttt gtgacatccc tgcagggatg gagttaacat
     4321 ttaattacaa cttggactgt ctgggcaatg gcaggacagt atgccactgc ggagcagaca
     4381 actgcagtgg tttcctagga gtgcggccaa agtctgcatg tacgtcagca gctgacgaga
     4441 agacaaaaaa tgccaagtta aagaagaggc ggagaggcaa agcagaggcc aagcaaatcc
     4501 atgaggatta ttgttttcag tgtggggatg gtggagagtt ggtcatgtgt gacaaaaaag
     4561 actgtcccaa agcgtaccac ctcctatgcc ttaacctgac tcagccaccc tacggaaagt
     4621 gggagtgccc gtggcatcag tgtgacgagt gtggcagtgc agccatttcc ttctgtgaat
     4681 tctgtccaca ctccttctgt aaggctcatg aaaagggggc tctggtaccc tctgcactag
     4741 aaggtcgtct ctgctgctcc aaccatgacc ctgcatctcc tgtgtcaccg gaatactgga
     4801 gcaagatgag atgtaaatgg gaatcccaag atggtgggga agaagtaaag gagtgagagg
     4861 tggtgacttc cttccctgca gctcgcagtc ccagaggcaa cagagcacgc actgtgcttg
     4921 ccaccatcca caccgccttc taaccgatgg gagctggctc acacaggcta aagcacggtg
     4981 gtgtttccta ttgtgttgtt tgggggataa tttgtggaca gcagaattcc cttggtcttt
     5041 tcttgcctat tattgtgctt cagtgtcttt gcagtcagca aaagaggtgt cctcgttctt
     5101 agagttgaaa gttaaaagaa tgttttgtcg ataagatcgg tgtaaagcct gaaatgtaaa
     5161 tcctgggttg tgtaaagcga aagcagccac tcctgtattt atttcctttt tttaggaatt
     5221 ctgagaagtg tagttgaaac agtctaacct ctgtgagcgt gcatgggtgc gtgcgtgcgt
     5281 gactaccttt atatacctct ttactgagcc gtagattggc taacttctct ttcccttttc
     5341 acatgccttt tcttgtgtca gagaaggctc tcagcaagta ttcagactgg cctcttggaa
     5401 acaaactgct cgacagcatt tacctctgtg gtgggcttca cagtgcgcca actctaccta
     5461 gaagcatcct gtagggaaaa ggaatgagtg cactcactca ttgtgaaatg tcacccgttc
     5521 acagactttt ctgatacatt tgagggacgt ggatgcacag gaaaatgctc ctttctgctc
     5581 ctcaccactg ggaaggggct aagaaagatt aaggcacaga ccaaaagttg ggtcatatat
     5641 gcaccacttt ctgaccagtt taatgtagac tccagtctaa cctggaactt aagggcattt
     5701 tattttctgt ctttccctct gccgaccccg ttcccttgca ggctgggtca ctcagtcatg
     5761 ctttctggca aagctatgta attgaatctg aattatattt taatagactt tctcagttga
     5821 tttcctaact tagggatggt gcaagtggac agaaacatcc ccaagttata tgtgaacaat
     5881 ttctacttag tattacgcaa tacttaagat tgtccccatt gcctaagggg aagaagttgc
     5941 tctttcacag ggtatgtagg agccacagag gcgttcctgt tagaaagcac ttgaaaatgc
     6001 cccccagaaa gtcagtgttt gcaaacatgg ctgtgacgtt tgaatcgttt gaatagtaca
     6061 gacccagcat accaaggtgt ctgcccacag aattcacttg catctagcac ttaggaatat
     6121 atctattcca gtattacttg tctgaaatca tggtggacat ggtgacatta gactaaatgg
     6181 cagtctggtg ttaccatgaa acatgaactt tctcagtgag ttctaactgc ttactggagg
     6241 tacccagtag gacttattgt ccttaagaac caagtacttt actagtgtag gagatgctct
     6301 acgacaccct gaggttgtgt taggtgtgtt ctgatccttt cttaatttta tacaagtcaa
     6361 ttcagacctc ttctctgaac aaaagaaaga gcaatttttg tgcctctttt taaaatatat
     6421 ataaatgtgc aatttatagg caacaaacac tacagttcct ctctctaagc tcctaaactg
     6481 ccattttcct agttgtagca attctagtag ttctgctggt tggacaggct ccgtgaggag
     6541 ggaggcgggg tggaacagca tctagtgagt gcggtcacca cgactggagt gaggcactgc
     6601 ctacacaaac actaaagcaa ttatgaagtt tgatgtcctt taaaaaaata atgtaagagt
     6661 atctgggttt tatcatatta aattttattt tatacagaca tgataacatt ttttaaactc
     6721 cttaataagg gactttgata ctccaaatgt aacccttatg agaacaatat ccgatgtgag
     6781 attgtatctt ctttcctttt tgacctcatg ctttttagta tctgataact tttatagagt
     6841 aagccccggg gtgcatcgtg tatttataaa taccttaccc cgacctgtct ctgttctgct
     6901 tctctgggat ggcttacttg tgtttatatc cataaaaggg gtttgcactt tccaagtctg
     6961 ttcttgctaa acggctcata ggtttgctcc cagaagcact catgctccaa acttgccttt
     7021 gctgtgccag tgcaagggtt tcttcctgtg ccattgtggc ctgggtctta gaatggagtg
     7081 ttaagaaaac agaaagtgta catacactgt cctttcatgt cctatgtcag tgacattcca
     7141 aaaggcactg tgcttacaga gtctgaagct ggtagttgtt agctttgaaa tatgattttg
     7201 gtatacagta tttgtggtcg attttattca gcccagaaat caaggaccta aagcagcatg
     7261 ggataatagt ggtatttcct aacctcagga ggaagatgag attctgatta tcagtgtaaa
     7321 gctttagaag gttggccgga aagagctaga aatgatagtg ccaggtcagc ataggctgtg
     7381 ccttggaggc ctcactgggc tgccagtgta gctgcctgtg cctggctgct taggacaggg
     7441 ccaaagctct tcactacccg tgtgccgcag ccaccgctga cttgagtcaa gctgtcttga
     7501 gtcaggcttg gagagcagag gggggtaggg ttatcttcac ttgctctgcg agccctactc
     7561 tatttttaat tctcaaaaat gacctttcct aagctgtaga atagactgag ttttctgtgt
     7621 gttatataat tgacattata tatgtacata tataatgttt tatttatata tatatgagat
     7681 gcacacacac acacacacac acacacacac acacacacac aaagtaggaa gtatttgaaa
     7741 ctaaagacct aagaagggcc ctgcagcccg ctgctttctg tcagtgtctc tcgctgcagt
     7801 gtttgcagaa gtgtgtgtag gtgatgtgga tctgagattc tgaggcgctc tccgtctgct
     7861 catctgaagt actcggggac tggtaggcag cttctctgca gtagttcctg ttctgagcac
     7921 gttcttacag gatgtgttct gtcagggtca aagccagact agtttgaaat cctaacgttc
     7981 tctgttcaga acatagtgcc tggctctcca ggagccactg ctgaccttgt caagacaaca
     8041 ctcatcttgc cttcgtccgc acagagctaa gatgctgcca gccaggtacc atgtcctgat
     8101 tggagaggaa aacaagttgc ctttgtctct aagctctaac aacttgcagt gtctctgttc
     8161 ctcaggagat gacaaggctt tgctttattt ctagacttga gttccttttc actgcatccg
     8221 accaccccat actctgccaa gttgctaagg gcagcaccag aagtgatggg atggcgaggt
     8281 ccttcaaagg agtgcccaca cttggtctct gcttatattc ataacagaac ggttacaaaa
     8341 agggttggtc cattttcaga tggaccaaca ggacgaatgt agactgctct gcagtgggtt
     8401 agcaaataca gaaagctggg catttgtatg aactgaaata tcacagcttt gacctcgggg
     8461 aggtactgga aatcttggga gaaagggagg gaaaagcaca ctacagttcc cgtgacactg
     8521 agacccctgc cccattgatt tcaggctcct caagtacttg ggacttcaga ttctcatttt
     8581 acattttata tttttaaaat tatgaagtag aaagcatcat tctgtatcct gtcaaaaatg
     8641 aagtctcccg acgggagcat agacctctga ggaaggggct cctgcatgag ctgtgagcag
     8701 cagtttgaga agtgatttcc ctagtttttg ttttgctttt ttcccccttt gtttgcctca
     8761 tccccgagta cctcttcttt ctgtttaaca tgtgcctgtg tggggaggag gggagcattt
     8821 atgttattcc cctgaaatgc tttgtataac ctgtttcaaa acccatttct tctgggcatg
     8881 gttgcacagg cctttaaccc tagcactgca gaagcagagg cagccatact ctgtgagttc
     8941 aaggcctacg taatgagttc ccaatcagcc agggctatgg agagagacct tgtctcaaaa
     9001 gaagaaaaag aaaaaaattg tttggctttt atcaatccat tgcacaagtg gcagatgtga
     9061 gcacttgtac ctgtgtgggg gagggggaaa aaaggatcac ttgtccttca gtaggctccc
     9121 aaagtcatta acatgtacgt taaagggaaa atagaagttg ccaaagtcag tattcggtcc
     9181 tgggttttct tgtgacttca ctgcgtctac taagagatga gaagcttcct tacctgctga
     9241 ctgatcctgc ctgtgtgcaa tggctttcac ctgtctgcca gtttgctcaa ttgggtcttc
     9301 tctgtcagct gaaagcagtg agggaaatta cacttttgtt gttagttaac atctcatatt
     9361 ttgtacccta tggtaactgt gttgctgcca ataaccaaga tgctaaatga ttactgctgg
     9421 ctaaaagacc tttttatata caaagacgtg tgtattttca actgatatgg caagttcatg
     9481 tgtgtccatt tgaatattac acaataaaca catactgtgg attccatctt cactttgtgt
     9541 tctttgaata acgtccttga gattgtttac gtctgtgttt acctgtaatg aactctgtgg
     9601 acctgtgaaa tatccaagtg tcaacatcca ctagtcagtc tctttagctt ctgtgacttg
     9661 gagctcctaa cactaaggga ttagtgttcg ttttccccag gggtatttga ctagggcatt
     9721 actgtttaat gacttcaaga catattttaa ggactttgtt tattgaccaa tgtcttattg
     9781 caaagtatga gcctaccagt cgtggttacc ctgtacagag atagctgtta acgagtcgta
     9841 gtgtatgtga gatcgcttgt aacatttaag ctgctttctg atgtgtgctg gtgggacagt
     9901 ttttgtacac tgtatttact agaactttgc ctttttaatc ttacagatac tttagaattc
     9961 aaatatgttt tctgcttctg taagaatgtg ggaaagcttt taataatggc attccaaatt
    10021 gatttcaggt cttgcttgag gttgacttta ataaattgtc ctgtatggtc tacttaa
//
LOCUS       NM_001436832            3666 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine repetitive matrix 1 (Srrm1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436832 XM_006239182
VERSION     NM_001436832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Lapolla,A., Porcu,S., Roverso,M., Desoye,G., Cosma,C.,
            Nardelli,G.B., Bogana,G., Carrozzini,M. and Traldi,P.
  TITLE     A preliminary investigation on placenta protein profile reveals
            only modest changes in well controlled gestational diabetes
            mellitus
  JOURNAL   Eur J Mass Spectrom (Chichester) 19 (3), 211-223 (2013)
   PUBMED   24308201
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Tange,T.O., Nott,A. and Moore,M.J.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   6  (bases 1 to 3666)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006239182.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1866106.1,
                                           SRR26643284.8149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000005.1  152875390-152875435 c
            47-136              JAXUCZ010000005.1  152870802-152870891 c
            137-259             JAXUCZ010000005.1  152870321-152870443 c
            260-430             JAXUCZ010000005.1  152868094-152868264 c
            431-546             JAXUCZ010000005.1  152867543-152867658 c
            547-750             JAXUCZ010000005.1  152866067-152866270 c
            751-939             JAXUCZ010000005.1  152864590-152864778 c
            940-1059            JAXUCZ010000005.1  152864177-152864296 c
            1060-1334           JAXUCZ010000005.1  152861132-152861406 c
            1335-1415           JAXUCZ010000005.1  152855768-152855848 c
            1416-1502           JAXUCZ010000005.1  152855321-152855407 c
            1503-1647           JAXUCZ010000005.1  152852539-152852683 c
            1648-1689           JAXUCZ010000005.1  152852153-152852194 c
            1690-1818           JAXUCZ010000005.1  152850411-152850539 c
            1819-2280           JAXUCZ010000005.1  152847583-152848044 c
            2281-2476           JAXUCZ010000005.1  152846792-152846987 c
            2477-2686           JAXUCZ010000005.1  152844978-152845187 c
            2687-3666           JAXUCZ010000005.1  152843167-152844146 c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3666
                     /gene="Srrm1"
                     /note="serine and arginine repetitive matrix 1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
     exon            1..46
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2794
                     /gene="Srrm1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/arginine repetitive matrix protein 1;
                     serine/arginine repetitive matrix 1"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 1
                     isoform 1"
                     /protein_id="NP_001423761.1"
                     /db_xref="GeneID:313620"
                     /db_xref="RGD:1311258"
                     /translation="MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVN
                     LEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFM
                     GELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKE
                     SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKE
                     KSPELPEPSVRMKDSSVQEATSTSDILKAPKPEPVPEPKEPSPEKNSKKEKEKTRPRS
                     RSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPP
                     RHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP
                     PRRRHRPSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPS
                     PAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKRS
                     HVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSSRRRRSPSPPP
                     ARRRRSPSPAPPPPPPPPPRRRRSPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSP
                     SPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSPPVTKRRSPSLSSKHRKGS
                     SPGRSTREARSPQPNKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRR
                     VSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWS
                     PAAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAV
                     ATPAPAAPAAVSAAATPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMR
                     KAQVSPQS"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    161..370
                     /gene="Srrm1"
                     /note="PWI domain; Region: PWI; pfam01480"
                     /db_xref="CDD:460224"
     misc_feature    <1190..2476
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1190..2476
                     /gene="Srrm1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            47..136
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..259
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..430
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..939
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1059
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1334
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1415
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1502
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1647
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1689
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1818
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2280
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2476
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2686
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..3666
                     /gene="Srrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgatctcc gagcgaggca gcaagatgga cgcgggattc ttccgcggaa caagtgcgga
       61 gcaggataat cgattcagca acaaacagaa gaaactcctc aagcagctga aatttgcaga
      121 atgtctagaa aaaaaggtgg acatgagcaa agtaaatttg gaggttataa agccttggat
      181 aacaaaaaga gtgactgaga tccttggatt cgaagatgat gttgtgattg agtttatatt
      241 caaccagctg gaagtgaaga acccagattc caaaatgatg caaatcaacc tgactggatt
      301 tttgaatggg aagaatgcta gagagttcat gggagaactg tggcctctgc tgttaagtgc
      361 acaagaaaat atcgccggaa tcccttctgc tttcctagag ttgaagaagg aagagataaa
      421 gcagagacaa attgaacaag aaaaattggc gtctctgaaa aaacaagatg aagataaaga
      481 taagagggat aaggaagaaa aagaaagcag cagagagaag agggagcggt ctcgcagccc
      541 aagaagacgc aaatccagat ctccttcccc tagaagacga tcttcccctg tcaggagaga
      601 gagaaagcgc agtcactctc gatctccccg tcacagaacc aagagccgga gcccttcccc
      661 tgccccagaa aagaaggaga aatctccaga gctcccagaa ccatcagtga gaatgaaaga
      721 ctcttcagta caagaggcca catctacaag tgacatcttg aaagctccca agcctgagcc
      781 tgtaccagag cccaaagaac catctccaga aaaaaattcc aaaaaggaaa aggaaaagac
      841 tcgaccaaga tctcggtcac gttccaaatc acggtcccgg actcgttctc ggtcaccttc
      901 tcatacgaga cccagacggc gacatagatc ccgatcaaga tcatactctc ctagaaggcg
      961 accaagcccc agacgacgac catctccccg aagaagaact ccaccaagac ggatgcctcc
     1021 tccaccacgg cacaggagga gtaggtctcc agggagacga aggagacgtt cttccgcatc
     1081 gctgtctgga agtagctcgt cgtcctcttc atctcgttcc cggtcaccgc caaagaagcc
     1141 tcccaagagg acatccagcc ctcctcggaa aactcgtagg ttatcacctt cggcaagtcc
     1201 tccgaggcga aggcaccggc cgtcatctcc agcaactccg ccacccaaaa ctcgccattc
     1261 cccaactccc cagcagtcaa accgtgcaag aaaaagtcgt gtgtctgtgt ctccaggaag
     1321 aacctcgggt aaagtgacaa aacataaagg cactgagaaa agagagtcac cttctccagc
     1381 acccaagcct agaaaagtgg agctgtctga gtctgaggaa gacaaaggca gcaaaatggc
     1441 tgcagctgat tctgtgcagc agaggcgaca atatagacga cagaaccagc agtcttcatc
     1501 tgactctggc tcctcttcca cctcagaaga tgagcggccc aagagatccc atgtgaagaa
     1561 tggtgaggta ggcaggcggc ggagacattc tccttctcgg agtgcctctc catcacctcg
     1621 aaagcgccaa aaagagactt cccctcggat gcagatggga aagcgatggc agtcgccagt
     1681 gactaaaagt agtagaagga ggagaagtcc ttccccacct cctgccagaa gacgacgatc
     1741 tccttctcca gcccctcctc cccctcctcc cccacctcct cggcggcgca gatctcccac
     1801 cccaccacca cgacgaagga ccccttctcc tcccccacgc cgccgctcac cgtctccaag
     1861 aagatactct cctcccatcc agaggagata ctctccttcc ccacctccaa agaggagaac
     1921 tgcctcgccc ccacccccac ccaagcgaag ggcatcgcca tctcctccac caaagcgccg
     1981 ggtttcccac tctccacctc ctaaacaaag aagcccccca gtcaccaaga gacgctcacc
     2041 ctccttatct tcaaagcata ggaaagggtc ttccccaggc cgctccactc gggaggcccg
     2101 gtcaccacaa ccaaacaaaa ggcactcgcc ctcaccacga cctcgggcgc ctcagacctc
     2161 aagccctccc cctgttcgaa gaggagcttc agcgtctccc caaggaaggc agtccccgtc
     2221 tccgagtact aggcctatta ggagagtctc caggactccg gaacccaaaa agataaaaaa
     2281 ggctgcctca ccaagccctc agtccgtaag aagggtttca tcttcccgct ctgtctctgg
     2341 atctcctgag ccaacagcta aaaagcctcc agcacccccc tctcctgtgc agtctcagtc
     2401 accctccaca aactggtcac ctgcagcacc agccaagaag gctaaaagcc caacaccaag
     2461 cccgtcccct gccaggaatt ctgatcaaga aggaggtgga aagaagaaga agaagaagaa
     2521 ggacaagaaa cataagaagg ataagaaaca caagaagcac aaaaaacaca agaaggagaa
     2581 ggctgtggcc gtagccaccc cagctcctgc tgcccctgca gctgtctctg ctgccgccac
     2641 tccatcagcc caggaagagc ctgcggcagc accagagccc aggaaggaga ctgagagtga
     2701 agctgaagat gacaaccttg atgacttaga gaggcacctt cgggagaagg cccttcgatc
     2761 catgcggaag gcccaagtgt ccccacagtc ctaggcggac atgtttgtta cgttgtaaat
     2821 tttatttggt ttgtactcaa ttcaatttca aaattgctaa aatgtgtttg agctttagac
     2881 tataacattt gttgtaataa ttgctaggtt gaagttcacc atgttaaaaa aggggggcat
     2941 ggatttacat tacaaaggtg tccacggtgt attagtgaca attcttccat tgacatttag
     3001 agtgaaatat tttaagccaa aaaaaaatct cttttttaaa aaagggggtt tgaatattgt
     3061 tggcattttt gtggttcctt taaatgccct cgcctctccc aaaaggttgg ggtcttttct
     3121 ttttctccct attctcttga atcttagcac ccatgtaaat tatgcttcca accttgtata
     3181 ggtttgtaag cttgcccaga agtgagagca ctgttgaagt accacagagg tttgggcgag
     3241 tgagtgttga ctctgttgcc catggagtct gctgtcctgg cagcatccca gctctagagc
     3301 gccgcactcc tgagctacag ggctgcccca tggaacagtt cctaaactga ctaggaactc
     3361 tgggttttct ccttccggtt gtgttgtttt gtttccttct ccccttttct tcctcttttg
     3421 taaaggcgat tcactagacc caggaaggac ccttcagtta cataaatttg ttttatgaaa
     3481 catggtggct cccattcatg gtttccctta ctcttccaat tggtacacac aactgaggag
     3541 ctcctgtatt tggccggctg gaagggcctg gacagtgtct tgatttcact tgttttattt
     3601 tattttattt tttaactaaa gctatataaa gcttgtggat taaacagaat aaatttctaa
     3661 atttaa
//
LOCUS       NM_001436830            1413 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C1q and TNF related 7 (C1qtnf7), transcript
            variant 2, mRNA.
ACCESSION   NM_001436830 XM_006251073
VERSION     NM_001436830.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Bi,J., Duan,Y., Wang,M., He,C., Li,X., Zhang,X., Tao,Y., Du,Y. and
            Liu,H.
  TITLE     Deletion of large-conductance calcium-activated potassium channels
            promotes vascular remodelling through the CTRP7-mediated PI3K/Akt
            signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (12), 1-11 (2022)
   PUBMED   36514218
  REMARK    GeneRIF: Deletion of large-conductance calcium-activated potassium
            channels promotes vascular remodelling through the CTRP7-mediated
            PI3K/Akt signaling pathway.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Rohrbach,S., Aurich,A.C., Li,L. and Niemann,B.
  TITLE     Age-associated loss in adiponectin-activation by caloric
            restriction: lack of compensation by enhanced inducibility of
            adiponectin paralogs CTRP2 and CTRP7
  JOURNAL   Mol Cell Endocrinol 277 (1-2), 26-34 (2007)
   PUBMED   17716811
  REMARK    GeneRIF: The purpose of the current study was to investigate
            age-dependent effects of caloric restriction on the release of
            adiponectin, expression and activation of adiponectin-related
            signaling and on parameters of altered insulin sensitivity.
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Wong,G.W., Wang,J., Hug,C., Tsao,T.S. and Lodish,H.F.
  TITLE     A family of Acrp30/adiponectin structural and functional paralogs
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10302-10307 (2004)
   PUBMED   15231994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006251073.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166720.1, FQ220553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000014.1  71792417-71792617   c
            202-447             JAXUCZ010000014.1  71686790-71687035   c
            448-1413            JAXUCZ010000014.1  71680478-71681443   c
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1413
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q and TNF related 7"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
     exon            1..201
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    126..128
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="upstream in-frame stop codon"
     CDS             189..1079
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; complement C1q tumor necrosis factor-related
                     protein 7; C1q and tumor necrosis factor related protein
                     7; adiponectin g"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 7 isoform 2 precursor"
                     /protein_id="NP_001423759.1"
                     /db_xref="GeneID:305423"
                     /db_xref="RGD:1306978"
                     /translation="MPRKEPKMIVLLYVTSLAICASGQPRGNQAKGESYSPRYICSIP
                     GLPGPPGPPGANGSPGPHGRIGLPGRDGRDGRKGEKGEKGTAGLKGKTGPLGLAGEKG
                     DQGETGKKGPIGPEGEKGEVGPAGPPGPKGDRGDQGDPGLPGVCRCGSIVLKSAFSVG
                     ITTSYPEERLPIIFNKVLFNEGEHYNPATGKFICAFPGIYYFSYDITLANKHLAIGLV
                     HNGQYRIRTFDANTGNHDVASGSTVIYLQPEDEVWLEIFFNDQNGLFSDPGWADSLFS
                     GFLLYVDTDYLDSISEDDEL"
     sig_peptide     189..257
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <375..>620
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <375..>620
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    654..1028
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     misc_feature    654..1028
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     exon            202..447
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1413
                     /gene="C1qtnf7"
                     /gene_synonym="Adig; Ctrp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgacagc atgagctcgc gctccacaca catccttcac ttttcttcaa gacacttctc
       61 tgcattgttg tggagcagct tgggtaataa acatatttct gctctgaata atttttaatg
      121 gtttctaaat tcatgggaga accaaagcaa ggaagtctga tgtttgggga ggacgtctga
      181 acccagcaat gcccaggaaa gagcccaaga tgattgtcct gctctacgtg acaagtcttg
      241 ccatctgtgc aagtggacaa cctcggggca atcaggctaa gggggagagc tactctccaa
      301 ggtacatctg cagcatccct ggcttacctg ggcccccagg tcctcctgga gcaaatggct
      361 cccctggacc ccatggtcgc attggccttc ctggaaggga tggtagagat ggcagaaaag
      421 gagagaaggg ggaaaagggc actgcaggtc taaaaggtaa gactggaccc ctgggccttg
      481 ctggtgagaa aggagaccaa ggagagactg ggaagaaagg acccatagga ccagagggtg
      541 agaaaggaga agttggtcca gctgggcctc ctgggccaaa gggagaccga ggagatcaag
      601 gggacccagg actgcctgga gtgtgcagat gtggaagcat cgtgctcaaa tctgcctttt
      661 cagttggcat cacaaccagc tacccagaag aaagactacc catcatattt aacaaagtcc
      721 tcttcaatga gggggagcac tacaaccctg caacagggaa gttcatttgt gctttcccag
      781 ggatctatta tttttcttat gatatcacgt tggccaataa gcacctagcc atcgggctgg
      841 tgcacaatgg gcagtaccgg ataaggacct ttgatgccaa cacagggaac cacgatgtgg
      901 cttcagggtc cacagtcatc tacctgcagc cagaagatga ggtctggctg gagattttct
      961 tcaatgacca gaatggcctc ttctcagatc caggctgggc agacagcttg ttctccgggt
     1021 ttctcctcta tgttgataca gattacctgg attctatatc agaagacgat gagttgtgat
     1081 ccggactgca ggcctgaatg ttgcaacatg agttccacag tggcttacac tctgatctaa
     1141 tctggagtgc tggaaggtgg agcaagtgat actgggattc agaacacatt ttttttacag
     1201 atggctctgg cagagttaac aaaataagac aaaccaccaa ccagttgaaa tcacaccaaa
     1261 atgaacggca tgcaataacc ccagacatgg accccctgaa gtaaagatcc taaatattta
     1321 agcaaattaa gatgatgtta acaaatttga atgcccttgg caatacaacc agcgggtagt
     1381 gacactgcct cattaaatat tcataaaact cca
//
LOCUS       NM_001436804            2372 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus beta-1,4-galactosyltransferase 2 (B4galt2),
            transcript variant 1, mRNA.
ACCESSION   NM_001436804 XM_006238667
VERSION     NM_001436804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Yoshihara,T., Sugihara,K., Kizuka,Y., Oka,S. and Asano,M.
  TITLE     Learning/memory impairment and reduced expression of the HNK-1
            carbohydrate in beta4-galactosyltransferase-II-deficient mice
  JOURNAL   J Biol Chem 284 (18), 12550-12561 (2009)
   PUBMED   19265195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238667.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.20525.1,
                                           SRR21887621.63796.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               JAXUCZ010000005.1  136707610-136707976 c
            368-723             JAXUCZ010000005.1  136705851-136706206 c
            724-959             JAXUCZ010000005.1  136705403-136705638 c
            960-1150            JAXUCZ010000005.1  136702152-136702342 c
            1151-1273           JAXUCZ010000005.1  136701810-136701932 c
            1274-1378           JAXUCZ010000005.1  136701595-136701699 c
            1379-2372           JAXUCZ010000005.1  136697857-136698850 c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2372
                     /gene="B4galt2"
                     /note="beta-1,4-galactosyltransferase 2"
                     /db_xref="GeneID:313536"
                     /db_xref="RGD:1305358"
     exon            1..367
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    153..155
                     /gene="B4galt2"
                     /note="upstream in-frame stop codon"
     exon            368..723
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..1529
                     /gene="B4galt2"
                     /EC_number="2.4.1.38"
                     /note="UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
                     polypeptide 2"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 2"
                     /protein_id="NP_001423733.1"
                     /db_xref="GeneID:313536"
                     /db_xref="RGD:1305358"
                     /translation="MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSR
                     FSTRSPAHALYPAASSSTNCSRPNTTAASSGLPEVPSARPGPTAPVIPPCPDVPPGLV
                     GRVVIEFTSPMPLERVQRENPGVLLGGRYSPPDCTPAQTVAVIIPFRHREHHLRYWLH
                     YLHPMLRRQRLRYGVYVINQHGEETFNRAKLLNVGFLEALKEDATYDCFIFSDVDLVP
                     MDDRNLYRCGDQPRHFAIAMDKFGFRLPYASYFGGVSGLSKAQFLRINGFPNEYWGWG
                     GEDDDIFNRISLTGMKISRPDVRIGRYRMIKHDRDKHNEPNPQRFNKIQNTKMSMKWD
                     GIGSVRYRVLEVSRQPLFTNITVDIGQPMSWLTQG"
     misc_feature    843..1493
                     /gene="B4galt2"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    843..1493
                     /gene="B4galt2"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    order(858..860,864..866,870..872,975..977,1056..1064)
                     /gene="B4galt2"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(858..860,864..866,870..872,975..977,1056..1064)
                     /gene="B4galt2"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(1056..1058,1062..1064,1341..1343)
                     /gene="B4galt2"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(1056..1058,1062..1064,1341..1343)
                     /gene="B4galt2"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     exon            724..959
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1150
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1273
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1378
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2372
                     /gene="B4galt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagccgt agcgcgggag ggaggcggca gcgcagtggt ccgtcggtcc gccggtccgt
       61 gggtctgccc ggccccgccc tgcctcccgg ggcggctcgg ctccatggcc cgcggcggcg
      121 gcgggaggtg gcccgggagc ctcggggacc gctgaccggg cggtggggcc gggccatggg
      181 ggacagagcg gtccacagca gctggagccg ggatccctac ccgagctgga gcggcgcccc
      241 ctgctgagcc ccgagcgctg cgtgagagga gggcgcgcgc ggccccccac ccagggcccc
      301 gacattccag acccggcccg gctagggggc cgcccgcgcg ccgccacaga tcccagtcca
      361 ggacccggct ggcagccgga tgcttggtcc cattgggcgg gccattggcc acctgcggga
      421 tgagcagact gctggggggt acgctggagc gggtctgtaa ggctgtgctc cttctctgcc
      481 tgctgcactt ccttgtggct gtcatcctct actttgacgt ctacgcccag cacctggcct
      541 ttttcagccg cttcagtacc cgaagcccag cccatgccct ctaccctgca gccagcagca
      601 gtaccaactg ctctcggccc aacaccactg ctgccagctc cgggctccct gaagtgccca
      661 gtgccaggcc tggccccaca gctccagtca ttccaccctg tcctgatgtg ccgcctggtc
      721 ttgtgggccg agtggtcatc gaattcacct cacccatgcc tctggaacgg gtgcagaggg
      781 agaacccagg cgtgctcctg ggcggccgct attctccacc tgactgcacc ccagcccaaa
      841 cggtggcagt catcatcccc tttagacacc gggagcacca cctacgctat tggctccact
      901 atctgcaccc catgttgagg cgacagcggc tgcgctacgg tgtctatgtc atcaaccagc
      961 atggcgagga gaccttcaac cgagccaagc tgctcaacgt gggcttccta gaggcactga
     1021 aagaggatgc cacctatgac tgcttcatct tcagtgatgt ggacctggtc cctatggatg
     1081 accgcaatct gtaccgttgt ggtgaccagc cccgccactt cgccattgcc atggacaagt
     1141 ttggcttccg gttgccctat gccagctact ttggaggtgt gtcaggcctg agcaaggccc
     1201 agtttctgag gattaatggt tttcccaacg agtactgggg ctggggcggc gaggacgatg
     1261 acatcttcaa ccggatctcc ctgactggga tgaagatctc acgcccagac gtccggatag
     1321 gccgctaccg catgatcaag cacgaccggg acaaacataa cgagcccaac cctcagaggt
     1381 ttaataagat tcaaaacaca aagatgagca tgaagtggga cggcattgga tccgtgcggt
     1441 accgcgtctt ggaagtatct cggcaaccac tcttcaccaa catcacagtg gacattgggc
     1501 agcccatgtc atggctcact caaggctgac actaacggac aaaggccctc catgcccttc
     1561 tggtatggaa ggctgcctgc cagaggactg acctataacc tggctgacag ctgctctagg
     1621 ggtgtcccca agactgagac tgtgagctgt tttctgagtc ttaatagcca gcgcacctag
     1681 aagtttcaga actcactttg aggggcgttt gggcaagccc ctcttacggc cctctctggg
     1741 gtcaaccctt cttcctgtcc tacttttccc agcccaaacc tcctcactgt tagggttggg
     1801 ccagcccctg cactgcctcg cggagtggcc tgagctaggt cactccacct ctctgtgcct
     1861 cagtttcccc actcccctcg agtcccctag ggcctggaaa ggtgggaggt ttaactaggg
     1921 ggcaatgtct cttccagggg ggaattctca gatctggaga cccctcatgc ttccagggga
     1981 ggggaaacct ttttcattca atattgtagg gggcaagctt tggcaagcca cctactgagg
     2041 agcgccccca ggaggggacc agaaggggtg ctgtgttgtt tcctgggatc atggggttgg
     2101 cctttgcatg ggggacaggt gggcctggat cagtcagtgg ttctggcctc cctcccttag
     2161 agaggaggca ggagccccag ggcctactct gtttttatgt tgcacagaaa cttgtgtggg
     2221 tgctttagta aaaaacgtta acggagcagc tccttgtctg tttgtgaaag ggatctggtt
     2281 ccctgaagct agtttgtgtt gtgggaggtg acctgggtag gggtcttcta gtgacttaat
     2341 aaatttccta gccccgtcct agggggaaag tt
//
LOCUS       NM_001436816            9579 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus storkhead box 2 (Stox2), transcript variant 1,
            mRNA.
ACCESSION   NM_001436816 XM_017600114
VERSION     NM_001436816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9579)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 9579)
  AUTHORS   Fenstad,M.H., Johnson,M.P., Loset,M., Mundal,S.B., Roten,L.T.,
            Eide,I.P., Bjorge,L., Sande,R.K., Johansson,A.K., Dyer,T.D.,
            Forsmo,S., Blangero,J., Moses,E.K. and Austgulen,R.
  TITLE     STOX2 but not STOX1 is differentially expressed in decidua from
            pre-eclamptic women: data from the Second Nord-Trondelag Health
            Study
  JOURNAL   Mol Hum Reprod 16 (12), 960-968 (2010)
   PUBMED   20643876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_017600114.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000016.1  51580823-51581091
            270-709             JAXUCZ010000016.1  51581286-51581725
            710-862             JAXUCZ010000016.1  51796410-51796562
            863-3128            JAXUCZ010000016.1  51806139-51808404
            3129-9579           JAXUCZ010000016.1  51813459-51819909
FEATURES             Location/Qualifiers
     source          1..9579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..9579
                     /gene="Stox2"
                     /note="storkhead box 2"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
     exon            1..269
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..709
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    319..321
                     /gene="Stox2"
                     /note="upstream in-frame stop codon"
     CDS             340..3324
                     /gene="Stox2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     knockout CG10573-PA related; storkhead-box protein 2;
                     spinelinin"
                     /codon_start=1
                     /product="storkhead-box protein 2 isoform 1"
                     /protein_id="NP_001423745.1"
                     /db_xref="GeneID:306459"
                     /db_xref="RGD:708477"
                     /translation="MPGKMEKFLQIAPHSLAIVLGPADCPAEEKPGTIQPSPQVPTQP
                     RQLARHHIGYEIFADFKAENMQHFWNKKVTAAVAETFFLGWIDEQVLLIQGKEEHLEA
                     LREGWTRRALRPPSGFQIRCLGDVSPISMSPISQSQFIPLGEILCLAISAMNSARKPV
                     TQEALMEHLTTCFPGVPTPSQEILRHTLNTLVRERKIYPTPDGYFIVTPQTYFITPSL
                     IRTNSKWYHLDERVPDRSQCTSPQPGTITPSASGCVRERTLPRKHCDSCHCCREDMHS
                     MHASTLQRKPAKDCKDPYCPPPLCQVPPTDKSKSTINFSYKTETLSKPKDGEKQSKKF
                     GLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDEDTPTTIPREVEMEIIRRINPDLTV
                     ENVMRHTALMKKLEEEKAHRSKAGSSAHHSGRSKKSRTHRKSHGKSRSHSKTRVSKGD
                     PSDGSHLDIPGEREYEFCDPLTRAPREGCFIIEHKGDNFIMHSNTNVIESHFPMTPEW
                     DVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSRNERSNKAKERSRSMDNSK
                     GPLGASSLGTPEDLAEGCSQDDQTASQSYIDDSTLRPAQTIGHQRAHIPSASYKEVCI
                     PEIVGGSKEPSSACSLLEPGKSPESMPSYGELSPCPAKTAVDDYFQCNTSSETVLTAP
                     SPLGKNKEDHDTLTLVEGVKKLSPSERQTPHSSRDPVGHKEESPKGPGGGPAASGGVA
                     EGLANGRLVQHHSAEPSNLDKRKEIFSKDTLFKPLHSTLSVNSYHKSSLSLLKSHPKS
                     PADTLPGRCEKMEPSLGTSAAQAMPPSQRQQEPGGNQEASFDYYNVSDDDDSEEGANK
                     NTEEEKNRDDVGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATHSARLDS
                     MDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPTFNFRASTDP
                     PTSEAEKLQKPSNCLQASVTSV"
     misc_feature    730..966
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     misc_feature    730..966
                     /gene="Stox2"
                     /note="Winged helix Storkhead-box1 domain; Region:
                     Stork_head; pfam10264"
                     /db_xref="CDD:431182"
     exon            710..862
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..3128
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..9579
                     /gene="Stox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccccctc cggatctgcc cggggctggg cgcttaaact caactctccc agctaaggtc
       61 gccgccttca cgctgtccgg taccggcctt cttggaattc ctctggccgg gtccagccaa
      121 gggaattccc cggatcacgg cgaaccgccc gccccctcgg cacccttcct ccggctctcc
      181 gcccccgctg gggttaccgg gtgccaagcg aggctagggt gccagggttg gaaaatgagc
      241 ggtgcccgga gggtggcccg gggctgcagt cactgtccgg tgccggttcc ctccagcagc
      301 ccgcagcggc ggcacccgtg agtgcagtcc gcgcggcgga tgcctggtaa gatggagaag
      361 tttctgcaga tcgcgccaca ctctctggcc atcgtcctgg gcccggccga ctgccccgca
      421 gaggagaagc ccgggacgat tcagccctcg cctcaggttc ccacccaacc ccggcagctt
      481 gcccgacacc acatcgggta cgagatcttc gcagatttca aagcggagaa catgcaacac
      541 ttctggaaca agaaggtcac agccgcggtg gctgagactt ttttcctagg ctggatcgac
      601 gagcaggtct tgctgatcca gggcaaggag gagcatcttg aggcgctgcg ggagggctgg
      661 acgcgcaggg ctctgcgacc cccttctggc ttccagattc gctgcttggg tgatgtgtca
      721 ccaatcagta tgtcccccat cagtcaatct cagtttattc cactcgggga aatcctttgc
      781 ttggccatct cggcaatgaa ctctgcgaga aagcctgtca cccaggaggc gctgatggaa
      841 cacctgacga cgtgtttccc aggtgttcca accccaagcc aagaaattct acggcatacc
      901 ctaaacacac tggtacggga gaggaaaatc tatccgactc cggatggcta tttcattgtg
      961 accccacaga cttatttcat tactccttcc ctcataagaa ctaacagtaa gtggtaccac
     1021 ttggacgaga gggtacctga caggtctcag tgtacctctc cacaaccagg aaccataacg
     1081 ccctctgcct caggctgtgt cagggaaagg acattaccca gaaagcactg cgactcttgc
     1141 cactgctgcc gagaagacat gcacagcatg catgcctcca ctctgcagag gaagcccgcc
     1201 aaggactgca aagaccctta ctgccctcct ccgctgtgcc aggtgccacc cactgataaa
     1261 agcaaaagta ctataaattt ctcttataag acggaaactc tctctaaacc taaagatggt
     1321 gaaaagcagt ccaagaaatt cggccttaag ttattccggc tgagttttaa aaaagacaag
     1381 accaaacagc tggccaattt ctctgcccag tttcctcctg aggagtggcc tctgcgagac
     1441 gaggacacgc ccacgactat cccccgggag gtggagatgg agatcatccg tcgtatcaac
     1501 ccggacttga cggtggaaaa tgtcatgagg cacactgcac tgatgaagaa acttgaagaa
     1561 gaaaaagctc accggagcaa agccgggtcc tccgcccacc acagtggaag gagtaaaaag
     1621 agccggactc accgaaagtc ccacgggaag tctcggtcac acagcaagac tcgagtgtcc
     1681 aaaggagatc cttcggatgg ctcgcatctg gatatccctg gtgagaggga gtatgaattt
     1741 tgcgaccctc taaccagggc ccccagagag ggctgcttca tcattgaaca caaaggagac
     1801 aacttcatca tgcacagcaa cacgaacgtg atcgagtccc atttccccat gacgccagaa
     1861 tgggatgtgt ctggcgaact ggccaaaagg agaacggaga tgccctttcc cgaaccttcc
     1921 aggggaagct cccactccaa agtgcaccga agccacagcc atacccagga ccggaggtcc
     1981 aggaatgaga ggtccaacaa ggccaaggag agatccaggt caatggataa ctccaaaggc
     2041 cccctgggcg cttcttctct cgggactccg gaagacctgg ctgaaggctg cagccaagat
     2101 gaccaaacag ccagccaatc atacattgac gacagtacgt taaggcctgc gcaaacgatt
     2161 ggtcatcaaa gggctcatat tccttctgcc agctataaag aggtgtgcat tccagaaata
     2221 gttggtggca gcaaggaacc ttctagtgct tgtagccttt tggagccagg caaatcccct
     2281 gagagtatgc cgtcttatgg ggaactcagc ccttgcccgg caaaaacagc tgtggatgac
     2341 tattttcagt gcaacacttc tagtgagact gtgctcacag caccgtctcc tttagggaag
     2401 aataaggagg accacgacac tttgaccttg gtggaggggg taaaaaagct gtctccatct
     2461 gagaggcaga ccccccactc ttccagggat cctgttgggc acaaggagga gtcaccaaaa
     2521 gggccaggtg ggggccctgc agcttctggt ggtgtggcag aggggttggc caatggccgt
     2581 cttgtccaac atcatagtgc agaacccagc aacttggaca aaaggaaaga aatattcagc
     2641 aaagacacac tgttcaaacc tctacacagc accttgtctg taaacagcta tcacaaatcc
     2701 agcttgtccc tcctcaaatc tcacccgaag tcacctgctg acacactgcc aggccgatgt
     2761 gagaaaatgg aaccttccct tgggacgtct gcggcccaag ccatgcctcc gtcccagcgt
     2821 cagcaggagc ctggagggaa ccaggaggcc tcctttgact attacaacgt ctccgacgac
     2881 gacgactctg aggaaggggc caacaaaaac acagaggagg agaaaaacag agatgatgtg
     2941 ggcaccatgc agtggctcct cgagagggag aaggaaagag acttgcagag gaagtttgag
     3001 aagaacctca ccctcctcgc cccaaaggaa accgatagca gcagcaacca gagagccacc
     3061 cactcagccc ggctcgacag catggacagt agcagcatca ccgtggacag cggattcaac
     3121 tccccacgca ctcgggaaag cctggcttcc aacacatcaa gcattgttga aagcaaccgc
     3181 cgtcagaatc ctgctttgag tccggcccat ggcggagctg gtccaacctt caacttccgc
     3241 gccagtacgg atcccccgac cagcgaagct gagaaattac agaaaccttc caactgcttg
     3301 caagcttctg ttactagtgt atgattgtcc ttctgcctca gatcttctgt ctcattcgat
     3361 acagcaacgt ttacgacgat tgggactgat gtttacatct cttcaaaggc aaacatctca
     3421 agcacaggtt gggggttact tgagctgtgc tgctaagtag gctagggcaa aaaaaaaaat
     3481 cttcatttca gagtattgct tttcacatgt atggctctgt agctaccaaa tagcagtatg
     3541 ggagatacgt acacttccgc ttcactaatt gtatctgagc acacatagga aagtctaaac
     3601 actgtaagtg gaacatgcat ttttcgatgt catacagttg ccaattccat tctgaaaatg
     3661 ccacagagat gtgttgctcc ctgccggcct acggggtacg ggccgtggga ctcatccttg
     3721 ataaccccgc cccctcaaac ccccgccccc tcaaaaaaaa gccaagccgc cacaaaatgt
     3781 aaatgtaggg gtgtgtccat tgtgagaaaa aacagtgcca aactgggcag aagggacccc
     3841 agccctttat gtgtgagtcc tttaaagtac cagtcatttt tcactgtgag ttttcacgac
     3901 actcttgcag gagcccatgg aagtgggtca gaggtcccaa tggaagttgt tggggtattt
     3961 gtttttactg ttttccagct cactaaatgc ttgtcttgag ttttttgttt ttttaacctt
     4021 ccctaatcac aaacaggaat ataggccttt gaggtggaca aaggaaagga aatgcggtct
     4081 catgggggca cagcactgag tgctggagaa gggtgtgtgg atgaccagga gggatgaatc
     4141 agatactgga gaaggatgct tccctccttg ggacacttag gatgatcgag ctgactatat
     4201 tagatgcggt gattaatctg ttgggaagta aaatgttctt tatgatacaa atgaagaatg
     4261 tggcccgagg gtgttattct ttctaatgga agggacataa atctatttta tgtagtttta
     4321 aatagaatgc ctaaattagg ctgtggagat gatttttagt ggttgtagga aaagagcaaa
     4381 tttagggaga gttaaacttc aggcctttta ttcctgggaa gatatctata gagacaacat
     4441 ttaaagtaat ttttgattag aaatatacat gggcccatgt aatgaacagc agaatgtcct
     4501 cattctgctg gcgtggtata ttcttaattt gtactcccct aaagtgtatc agaatgacac
     4561 ttatgcattc atgaactatg ccagagtaat gtttacagat actttgtagt gatttcagga
     4621 ggcgcctttt gggtggacat catctttgca atgacttctc caagctctgc tttggtttaa
     4681 gacgtcatgc tcagtatccc aaggctttgc aggaggggga ccactaacca ttacacttca
     4741 gtcctaccag aaaggctctc ttcaaaagtc ccttgatctt attttctgag acgcgtggca
     4801 tacctctgta ggttctgaaa atcttatctg cacgtgggtt aggtctgatc tcagaaaatg
     4861 gtctgaaaca aaattacatt cagttgagtg tcaaatgatt tttggagcca tatgctttaa
     4921 tgaatttata gataaataac ttaaaaatca gtataaaata ttttcactca agatttcagc
     4981 aatgagcata agtttgtgag ctacttcttt ttctgtgtca ggctgaatca ctagcaaggt
     5041 gtctaaggga gcacagtcat atgaagcagt tggaaacatg tacattcatt ttgtctgcta
     5101 tttggaagtt gtactattgg gtcaaactgg gctccttaag cttggtataa atttcttttt
     5161 cttgcttatt gtaatgaagc ttaagcacag ttctcagtat actgctacat tgttgaaatg
     5221 cttaagggaa ttggcttcga atcccatact ctacttcctc ctggcatgcc tcagttgttc
     5281 agaagcacat tgtttctctg attacttaag taatgtccag aaagagcaac catgtatctg
     5341 attactacat agtctgtttg cttaaggagc cgtacaccat aagattcctg gatctggtct
     5401 aaatcaattt gcccccccca ccccgcgccc taaaaaaacc tgctctgaaa cttttggcat
     5461 actcagttca taaataacag aactgttaaa acaatacact aatctctgat tgacctctga
     5521 acatagtagc cattgaaaga attgagtgcc gtgcgagcag gagaggacat aattatgttt
     5581 taagcgaagc tttaaaatat gcatttttga tagttcacca aaaacaggtt tacagaagac
     5641 attttccaaa caaaatgtgt acactatttg cctaatcact atggagtaca agatttaaaa
     5701 aaataataag tggataagca aaagaacttc ccttagacca gcagccatta gcactgaacg
     5761 atgggcttta aagatgatgt aacacataca cagacattcc gtggagaaac actctcgtct
     5821 gaatctaatc tggattcttg aatggagagg cattggtggt aggaggcaca tggcagtgtg
     5881 atgcgtacat gtgtctaaga tggtctcctc aaaatggtga gactctttga ctctcacagc
     5941 ctcgagactc tctccaggct tcgtcagttt tctccactgg aaccatagct ctgtgttctg
     6001 tgacggcatg tctagtttta gagtttatca acggaaaggt ttacaaaact gaatctggtt
     6061 gaatctctgt gaggcattca actttaaagg gtcaacacat ctgtcggcat tttgcacacg
     6121 tatgtattat tatgatacag catattactt tatggtaatt tttatttttt acatataact
     6181 acctccatga atttgatgaa atggcagcag tgtgtttaag tgtgttcttc agaaaaagca
     6241 atgttgcaaa cgtgtttcag cggtaggcca tggcgtggcg tgtgtgtcgg tgacttaccc
     6301 attggactca tgaccttttc attgccgtga ttttctttca caacattctt tggctcccaa
     6361 ctgtaagcct gttgtcctct ttttctctct cccttctccc ccatgaaagc acatttgatt
     6421 tgttacaaat gaacgaacat tttaaaatta ctgtcttccc tgcttctaca cgctcactat
     6481 tagagaaaaa aaaaagtctt ctctggcaaa gagccacttg gtaaacattt aggaagttat
     6541 taattcctat agaaattaca ttgaattgtt agggtgtttt tttccccagt aacaaaagat
     6601 atgtgaaaat tttggactgc caacttgaag cactttgggc ctctctgcct ctatgctacc
     6661 ctatggagcc caaacttttt tttattaaaa gaactgtgcc atgcattctg agatgtctgt
     6721 taagtaattt gtctaccctt tgattgcaca tctcaggaga ctttaatgag tgcaagaata
     6781 gggtgtgtgt gcacccaata gagaaaacca atgtgagagc tgaaatggga gtagccgggt
     6841 agaaataaga aatgccggtg tctttgatgt tggagaattc aagttcagga aatatgaatg
     6901 gaaagagaat gtggaggagc agtgatttga acaccagctg ttcctaaatg tctcttttct
     6961 gagaactcag ccaatattgt tacaatgtca ccaagacagg aaaggcagta aggacagaag
     7021 aacatagttt ctcttttagg ttagcatagc tttgtaaagt cctacctagg attatccact
     7081 ggtcaccaca aagtgtactt gaagataaag tttgtaactt cagtgatagg cacagttctc
     7141 acaaaaccat ttgggagggg tagcgttctg agcttgcact aacaaccaac gactggtaat
     7201 gttctgcagc tcatctggcg atctcaaagt gcttccgagg cattaggcgt acaattgcag
     7261 ggcaggtcca gtttctcata cccaggcttg acaggagcaa acaaatggag tgtcttgaga
     7321 tcacccataa acacaatggc agctctcagt gacctatttt ctatctgttt gataggccat
     7381 ggtgagaaat cactaagatg ctatttttat gatgtgtgct aataaagaaa acaaatacag
     7441 cttgacacct tgtccatttc attcaaagag gtatgggtgt ttggaatctc agcacctcag
     7501 caccccttac tggtattgag ttatgacgtg ggagaggagc aaatccacac caatgccact
     7561 gtcatccaaa gccagtccag gcatccacct ttgtttacag ctccttatta ggtccctgtc
     7621 atatctgtgt taaaacaaaa ccccatctcc aggaacattg gctgctccag gcagtggaag
     7681 gtgctgaaac agttgtgttt tttttctctt aattttcctt taaaatattc atcaagcact
     7741 cctcacagtg ttcagcaaca taccactcac tacgttatat caagccctgc ttcgtagaat
     7801 ctgggaagct gatccagttc caagagtttt gtcaaattat gagatagaag gtctttgact
     7861 tctgctttct cctttcccac agaccagacc cacacccaac tagcagtgca gtgcagacca
     7921 cagtagactc gaagtggtgc ttcctccccc gacccccgac ccccatccat tgtcaaagcc
     7981 atccaataat gtcctgtgag cgagggactc tttggcccgt gtttaaggct tggggaaatt
     8041 agaaacaaga aaaatgaatg caaaaagcca tgggaggcat tggtttcctt tgggctagtt
     8101 aaacatggtg gcaagggatt gctattgtat gagctttgcc aagaaataca aaagactcag
     8161 ccatcacccc atccttctcg aagaaggttt tatagtatta atgatacaag tgatattttc
     8221 ccatggagtt ttccttagga tacatttcat aaattataca catgagacat tttagcatta
     8281 gatctcatgt gtttgccaaa ggtactggct tctccctggc ttggagtcca tcctcttgtc
     8341 ttgcatcagc aacgcagagg ggctcctcgg tgatggcttc tagaatacat atgcctgtgt
     8401 ctttattgtt gtgcacaggc ttaacatttg caaaattgag aattcggcaa agctccaggg
     8461 gaactaagcg gtcttgtgat tgtatgcagg cagtcagagg cctttaatgg ctcattgtcg
     8521 gcttcacttg tgaacacata caccctcccg actaggaaaa gggtgtttcc aggtgaggta
     8581 ccaatggctt ggaaaggcag aaatggaagg ttagagcttg gctggtcctt gtgcacctgc
     8641 ctacctccct gtccaaaggc tgaccttggt acccgccccc cccccattcc ccttctctca
     8701 ccccaaaaga ggtaccaaat ctgagacccg agctctcctt caatcccagt cctctacagc
     8761 tccaggacct tcatatagaa cattctcgac agccccgcct tcctttcctc tgagcgttac
     8821 cctctccgcc tccccaccac caccagatac ctaccccacc accactcttt ccacattgga
     8881 agaacagaat actgtgtagt attgtgcacg catgccagtt aggagtagaa ctgccctagg
     8941 gtcaccttca catcagtgtc aacagctaca aacataaagt ccttagagca gtcacatcca
     9001 tactctctgg aagagaattc aatttgacca tctaagttcc aagggatcgt ggctctgcgg
     9061 gcgtctttct ctgtgtggct gactgtgact attacattag ggtcagtgag ctaagaagta
     9121 cgtgtgggat tcactgtgtt aggaaggagt tttgcagcca agactgcctt gaataaaaat
     9181 gtttttgcac tgaaaaaaaa aaactttaaa tgacttggtc tctggttgct gtaaaggtca
     9241 tccaagatgg atgttctgtt tatattgtat agtatttcat aagaaataac tgcagttcat
     9301 gaaacgtctt ccctaatgtt actgatttct aacagcacat ttgtaacatg gtttttatcg
     9361 tgtccgtgta ccatactgta aatgatgatt ccttgtcatg cttagtataa taagttaaaa
     9421 ggaaaaaaaa aaaggacagg gatttttgta agtctatatt tgaaagtccc tccatatggt
     9481 aatattgtgt tcatgttgtt tatgtagtgt tgtgtgaaat atccattttg gattgtgtta
     9541 ctttttaaga tattaaataa catttggtta tatgtgtaa
//
LOCUS       NM_001436796            4644 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus MIER1 transcriptional regulator (Mier1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436796 XM_006238479
VERSION     NM_001436796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4644)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4644)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   3  (bases 1 to 4644)
  AUTHORS   Ding,Z., Gillespie,L.L. and Paterno,G.D.
  TITLE     Human MI-ER1 alpha and beta function as transcriptional repressors
            by recruitment of histone deacetylase 1 to their conserved ELM2
            domain
  JOURNAL   Mol Cell Biol 23 (1), 250-258 (2003)
   PUBMED   12482978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238479.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.15368.1,
                                           SRR26643429.20124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  123105380-123105468
            90-190              JAXUCZ010000005.1  123106498-123106598
            191-215             JAXUCZ010000005.1  123118303-123118327
            216-361             JAXUCZ010000005.1  123122432-123122577
            362-523             JAXUCZ010000005.1  123130554-123130715
            524-656             JAXUCZ010000005.1  123131303-123131435
            657-721             JAXUCZ010000005.1  123132010-123132074
            722-794             JAXUCZ010000005.1  123134055-123134127
            795-946             JAXUCZ010000005.1  123138897-123139048
            947-1028            JAXUCZ010000005.1  123139751-123139832
            1029-1123           JAXUCZ010000005.1  123141269-123141363
            1124-1251           JAXUCZ010000005.1  123146672-123146799
            1252-1391           JAXUCZ010000005.1  123150654-123150793
            1392-4644           JAXUCZ010000005.1  123153405-123156657
FEATURES             Location/Qualifiers
     source          1..4644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4644
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="MIER1 transcriptional regulator"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
     exon            1..89
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1720
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="isoform a is encoded by transcript variant 1;
                     mesoderm induction early response protein 1; mesoderm
                     induction early response 1 homolog; mesoderm induction
                     early response 1, transcriptional regulator"
                     /codon_start=1
                     /product="mesoderm induction early response protein 1
                     isoform a"
                     /protein_id="NP_001423725.1"
                     /db_xref="GeneID:313418"
                     /db_xref="RGD:1562337"
                     /translation="MDGASPGGGGSSGGGGSGGGYGVVARFSQCLAEFRTWLRTNWLR
                     FNADKTDVMLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNF
                     SSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGC
                     SGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESE
                     EDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVI
                     VFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAARE
                     ELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQ
                     QTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSN
                     SNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKL
                     AHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND"
     misc_feature    725..874
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    725..874
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="ELM2 domain; Region: ELM2; pfam01448"
                     /db_xref="CDD:460214"
     misc_feature    1043..1177
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    1043..1177
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; Region: SANT_MTA3_like; cd11661"
                     /db_xref="CDD:212559"
     misc_feature    order(1043..1045,1133..1138,1142..1147,1151..1159,
                     1163..1171)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1043..1045,1133..1138,1142..1147,1151..1159,
                     1163..1171)
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    1205..>1645
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     misc_feature    1205..>1645
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /note="Mesoderm induction early response protein 1/3
                     C-terminal; Region: MIER1_3_C; pfam19426"
                     /db_xref="CDD:437258"
     exon            90..190
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            191..215
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            216..361
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            362..523
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            524..656
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            657..721
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            722..794
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            795..946
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1028
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1123
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1251
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1391
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..4644
                     /gene="Mier1"
                     /gene_synonym="RGD1562337"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgag tctcccggct gcaggcggat ggatggggcg tctccaggcg gcggcggcag
       61 cagcggaggc ggcggtagcg gcggcggcta tggtgtggtg gctcgattct cccagtgcct
      121 ggctgagttt cggacgtggt taagaaccaa ctggttgagg ttcaatgcag acaagacgga
      181 tgtgatgctg ccatctgttg agtcttcaag tccagggggc tcagcagcgt cagaggacca
      241 tgagtttgat ccgtcagctg acatgctggt tcatgatttt gatgatgagc gaacattaga
      301 agaagaagaa atgatggaag gagagacaaa cttcagttct gaaatagagg atcttgcgag
      361 ggaaggcgac atgccaatcg acgagcttct cagcctctat ggttatggca gcactgttca
      421 gttacctgaa gaggaggagg aggaggaaga agaggaggaa gaaggtgaag atgatgaaga
      481 tgcggacaat gatgacaaca gtggctgcag tggggaaaat aaagaagaga atataaagga
      541 ttcatcgggt caggaggatg aaactcagtc ttccaatgat gatccctcac agtctgttac
      601 ttcccaagat gctcaggaaa taatccgccc acgtcgatgt aaatattttg atacaaatag
      661 tgaaatagaa gaagaatctg aagaagatga agattatatt ccctcagaag actggaaaaa
      721 ggaaatcatg gtaggctcca tgtttcaagc tgagattcca gttggcgttt gtagatacaa
      781 agaaaatgaa aaagtgtatg aaaatgatga tcagcttctg tgggatccag aatatttacc
      841 agaagataaa gtgattgtct ttcttaagga tgcatctaga agaacagggg atgagaaagg
      901 tgtagaagca attcctgaag gatctcatat aaaagacaat gaacaggctt tatatgaatt
      961 ggttaaatgc agttttgata cagaagaagc cttgagaaga ctgagattta atgtcaaagc
     1021 agctcgagag gaattatctg tgtggacaga ggaagaatgt agaaattttg aacaagggct
     1081 gaaggcctat gggaaagatt ttcatctgat tcaggctaat aaagtccgaa caagatcagt
     1141 tggtgaatgt gtagcattct attacatgtg gaaaaagtct gagcgttatg atttctttgc
     1201 tcagcaaaca aggtttggaa aaaagaaata taatcttcat cctggtgtaa cggattacat
     1261 ggatcgtctt ttggatgaaa gtgaaagtgc tgcttctagc cgagcaccat cccctcctcc
     1321 caccgcctca aacagtagta ccagccagtc ggagaaagaa gacggcacgc tcagcaatag
     1381 caatcagaat ggtgtgtcat ctaatggacc aggagaaata ctaaacaaag aagaagtaaa
     1441 agttgaaggc ttacatgtta atggaccaac aggtggaaat aagaaaccac ttcttacaga
     1501 tgtggacact aatggttacg aagaaaataa ccttgccact gacccaaaac ttgcccatat
     1561 gactgcaaga aatgaaaatg attttgatga aaaaaatgag agacctgcca aaaggcggcg
     1621 gataaacagc agtgggaaag aaagtccggg ttcgtctgag tttttccagg aagcagtctc
     1681 acatgggaag tttgaggaac atgaaaacac aaatgactaa ctcttaggcc tattttactt
     1741 tctttgcagt aaagtctggt ttgactacaa ttttcagggt tgggggggtg acctttagaa
     1801 agctgatttc cttgaagcag ttgttaactc ttgaaattgg aattaggtcc taactttaag
     1861 aaatgggatt cataattcta ctttttgcaa gttcttttac ttcaaatttt gaagccctct
     1921 ttaaggatat aaaaacattg gtaaatttga atgacccaaa gacttaactg caccttctcc
     1981 tttgagaaac aagtcatatt tgactaaaag gtaatctttc cttattcttt atgaggaaga
     2041 aaaaagtttg tttctgttca acaccaattt tttttattat ctagaaatgt ctttacaaca
     2101 gacatttttc tctccataca aattgaacat cgtcattaag gaaaccctca tgaatcctga
     2161 aggttatgct agcatgattt ttatatgtag aagtttaaaa ataaaccaag tcaggtttgt
     2221 atttgtaaaa ttgttgacat caatgatgtc tttccatatt cttatctggg cttaagaaat
     2281 acattctgta tttttccaga ttctttgtag cctttgaaag atttttacag tacatatgtc
     2341 ttgactgagc tgtcctttct taatacaaaa aaagcttgta taattttctt aacttgtaca
     2401 gttggtaaac ttttatgaga ggaactgata ttctgagtct gtcagctttc attttatttt
     2461 gctaagattt ttctaatgaa tttttaagtg tgtgtgtagt taaccaagtc atgtttctta
     2521 tccaggtggt aaaagcattc ataaagaatt atgttatttt caaacttcta cttactgaca
     2581 taatttggga cttctaaatt tcagcatgat actcagatta caagcttgtt tgcatttgct
     2641 ataattttat aaattaattg tgaaacaaaa caaagactta ctgtcagctt aagtgtgtag
     2701 atgtatcgtg ctgaatagaa tcctgttcag ttactctcat gtgccctaca agatttctca
     2761 ttgtttcagt caacagaaag ggaaggtcac gtgatgttgc aatattgcca catccaagga
     2821 gtaactgttg acaggtagca atattcattt ttatgagaaa atagtggttt taagaatttt
     2881 cagatctttc cagttgtaat ccagtttgtc acatttgata ctttttccaa aatgaaacac
     2941 atacaaaata accattgttc tgtgtgactt taaaaagggt tattgcacta gccttgtaag
     3001 aatggatgcc attttattgt tagtgcaaaa ttcttcttac aaaatgtagt tttatacagc
     3061 tgatagacca atctatctct ggactgtttt ttagtgaatg atgattaact accttttctc
     3121 acacaggcac atccccaaat gctgccttca gtttgatctc agccgtcagt tcaagagcca
     3181 ctgctttcaa agacagatct gtgtcctttt agtggctcag ttgtctgatg cagggtgggt
     3241 taaggtttgc actgagaatg atcgcccagg cctctccctc atagtattct tacatttgtc
     3301 cagactgctt cccttcacaa tgggtacaaa cttttctttc cccaaatcag tattagaagc
     3361 caccttgaca gcacatcata ataatacgca tttactgttt tctgcagaaa tagtccagtg
     3421 agttgccttc aggtggaagt gctgagaagc acgagagggt ttagtttgtt ttattgaaaa
     3481 cattaattta tccagaatgg cagtaggtca agtaccttta gcagatggtc atagcttgtc
     3541 tccctgccca cccccacaga gtctcactgt gtagcccagg ctggcctgga acttaacaac
     3601 ccttctacct cagcccgcta atgctgagat tggaggtgtt tcccaccaca cccagcaaca
     3661 gtctattttc taaagcaggt tttattatat gagtccaggc catcccagct ccttgtcaca
     3721 ggtgatcttt aagtgatgct atgcttttta atcattacac tatggaagat gtcagtccgc
     3781 cttttaaagg atgcctctgc tcgacacgtt cttggacttc tcgaaactgt tgtaacagga
     3841 acgttttaag gaaattctca ggcatgttgg caaatgtgcc aggtgtataa gtgttcataa
     3901 atcttttctt tttaaagtat gcataatgaa acattcctct aatacacaag gctcagcttt
     3961 tcccaactat attctgtgtt tgtataggta tttcaccctt tgttcaaaaa atgcagccac
     4021 tgaaacttaa gtcattgcac ttttaaacag tttgacaata tcatgagtaa tctgcttaag
     4081 atttggtgta tttcctaact gttgaacact taagtaactg agatgagaaa ataagcattc
     4141 atgagtaggg atgtagctca gttgctggaa tgcttaccca acatgcatgc aaaatgggtt
     4201 ccatccccag taccacagga actgggtata gtggtgcatg cctgtcatcc taagcacttg
     4261 ggaggtggag gcaggagaat cagaagttca aggccatcct cattacctgg tgagttgagg
     4321 ccagcctgat atgctgactc agatagaaat ggctctgttg gtagttatta ggtcctagcc
     4381 aagcactgtc attttcatct ggaacataca atgatgatgt atttatgatg tattctcact
     4441 aaggttcaca atctgtaact cagttcaaca cagatctctt gagctttaaa aggtatttga
     4501 agtaatttaa gtaggcattc aaaattatga attagatgtt tttaaatttc tgcataataa
     4561 ttttgcactg taaaatatgt cctttctccc atttccttct gccattctga tatgctcatt
     4621 aaaatatttt tgtaagcata ctca
//
LOCUS       NM_001436768            4119 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus ring finger protein 20 (Rnf20), transcript
            variant 1, mRNA.
ACCESSION   NM_001436768 XM_006238154
VERSION     NM_001436768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4119)
  AUTHORS   Lai,C.Y., Hsieh,M.C., Ho,Y.C., Wang,H.H., Chou,D., Wen,Y.C.,
            Yang,P.S., Cheng,J.K. and Peng,H.Y.
  TITLE     Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates
            mGluR5 Transcription for Neuropathic Allodynia
  JOURNAL   J Neurosci 38 (43), 9160-9174 (2018)
   PUBMED   30201771
  REMARK    GeneRIF: RNF20-drive H2B monoubiquitination, which facilitates
            phosphorylated mGluR5 transcription in the dorsal horn in the
            development of neuropathic allodynia.
REFERENCE   2  (bases 1 to 4119)
  AUTHORS   Stracker,T.H., Roig,I., Knobel,P.A. and Marjanovic,M.
  TITLE     The ATM signaling network in development and disease
  JOURNAL   Front Genet 4, 37 (2013)
   PUBMED   23532176
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4119)
  AUTHORS   Wang,E., Kawaoka,S., Yu,M., Shi,J., Ni,T., Yang,W., Zhu,J.,
            Roeder,R.G. and Vakoc,C.R.
  TITLE     Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3901-3906 (2013)
   PUBMED   23412334
REFERENCE   4  (bases 1 to 4119)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   5  (bases 1 to 4119)
  AUTHORS   Liu,Z., Oh,S.M., Okada,M., Liu,X., Cheng,D., Peng,J., Brat,D.J.,
            Sun,S.Y., Zhou,W., Gu,W. and Ye,K.
  TITLE     Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor
  JOURNAL   Mol Biol Cell 20 (3), 757-768 (2009)
   PUBMED   19037095
REFERENCE   6  (bases 1 to 4119)
  AUTHORS   Shema,E., Tirosh,I., Aylon,Y., Huang,J., Ye,C., Moskovits,N.,
            Raver-Shapira,N., Minsky,N., Pirngruber,J., Tarcic,G.,
            Hublarova,P., Moyal,L., Gana-Weisz,M., Shiloh,Y., Yarden,Y.,
            Johnsen,S.A., Vojtesek,B., Berger,S.L. and Oren,M.
  TITLE     The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a
            putative tumor suppressor through selective regulation of gene
            expression
  JOURNAL   Genes Dev 22 (19), 2664-2676 (2008)
   PUBMED   18832071
  REMARK    Erratum:[Genes Dev. 2017 Sep 15;31(18):1926. doi:
            10.1101/gad.307207.117. PMID: 29051390]
REFERENCE   7  (bases 1 to 4119)
  AUTHORS   Tan,L.B., Chen,K.T., Tyan,Y.C., Liao,P.C. and Guo,H.R.
  TITLE     Proteomic analysis for human urinary proteins associated with
            arsenic intoxication
  JOURNAL   Proteomics Clin Appl 2 (7-8), 1087-1098 (2008)
   PUBMED   21136906
REFERENCE   8  (bases 1 to 4119)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   9  (bases 1 to 4119)
  AUTHORS   Kim,J., Hake,S.B. and Roeder,R.G.
  TITLE     The human homolog of yeast BRE1 functions as a transcriptional
            coactivator through direct activator interactions
  JOURNAL   Mol Cell 20 (5), 759-770 (2005)
   PUBMED   16337599
REFERENCE   10 (bases 1 to 4119)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 21, 2025 this sequence version replaced XM_006238154.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.14878.1,
                                           SRR26643298.27323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000005.1  68771586-68771719
            135-279             JAXUCZ010000005.1  68771864-68772008
            280-435             JAXUCZ010000005.1  68772781-68772936
            436-603             JAXUCZ010000005.1  68777806-68777973
            604-751             JAXUCZ010000005.1  68778083-68778230
            752-934             JAXUCZ010000005.1  68778519-68778701
            935-1053            JAXUCZ010000005.1  68781319-68781437
            1054-1200           JAXUCZ010000005.1  68783751-68783897
            1201-1278           JAXUCZ010000005.1  68784871-68784948
            1279-1398           JAXUCZ010000005.1  68785120-68785239
            1399-1578           JAXUCZ010000005.1  68788897-68789076
            1579-1714           JAXUCZ010000005.1  68790139-68790274
            1715-1836           JAXUCZ010000005.1  68790590-68790711
            1837-2201           JAXUCZ010000005.1  68790829-68791193
            2202-2319           JAXUCZ010000005.1  68792266-68792383
            2320-2469           JAXUCZ010000005.1  68793353-68793502
            2470-2682           JAXUCZ010000005.1  68793892-68794104
            2683-2808           JAXUCZ010000005.1  68794789-68794914
            2809-2949           JAXUCZ010000005.1  68795036-68795176
            2950-3051           JAXUCZ010000005.1  68795789-68795890
            3052-4119           JAXUCZ010000005.1  68796173-68797240
FEATURES             Location/Qualifiers
     source          1..4119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4119
                     /gene="Rnf20"
                     /note="ring finger protein 20"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
     exon            1..134
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            135..279
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            280..435
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Rnf20"
                     /note="upstream in-frame stop codon"
     CDS             307..3228
                     /gene="Rnf20"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 20, E3 ubiquitin protein
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1A"
                     /protein_id="NP_001423697.1"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
                     /translation="MSGIGNKRAAGEPGTSVPPEKKTAVEDSGTTVETIKLGGVSSTE
                     ELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE
                     NIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLA
                     TLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIMEEAV
                     QELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQW
                     DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE
                     NKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLY
                     NESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRK
                     EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL
                     NKTRLRSGSALLQSQSSTEDAKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEE
                     RERERREKEREREREREKEKEREREKQKLKESEKERDPVKDKDKGKHDDGRKKEAEII
                     KQLKTELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDL
                     EDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAVAKQEEEALLSEMDVTGQAFEDM
                     QEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQ
                     VVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKL
                     HDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDY
                     KARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI
                     G"
     misc_feature    <1264..3108
                     /gene="Rnf20"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <1264..3108
                     /gene="Rnf20"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    3004..3225
                     /gene="Rnf20"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 20 (RNF20); Region: RING-HC_RNF20; cd16814"
                     /db_xref="CDD:438463"
     misc_feature    3004..3225
                     /gene="Rnf20"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 20 (RNF20); Region: RING-HC_RNF20; cd16814"
                     /db_xref="CDD:438463"
     exon            436..603
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            604..751
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            752..934
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1053
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1200
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1278
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1398
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1578
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1714
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1836
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2201
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2319
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2469
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2682
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2808
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2949
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3051
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..4119
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccctgc ctccgcctcc gtgaagctca atccctcttg gagcaggtcc gaaatgaggg
       61 attgaatccc gcaccgccct tcgtaaataa cccctggaag ctgcgcgccc gcggcgggag
      121 ttgctagagc ccaggcgaga tccaactcag attgctgctt gccataggtt ccttgtcctg
      181 gagtttgaat tggaagccgg cggggtgtag actcgtgatg gtcgcgtttc tcgcgatcta
      241 gcatccattc ctcctccttt aagcatcgga accagtcaga aaaaatagct gtcatcttat
      301 accaagatgt cagggattgg aaataaaaga gcggctggag agccaggcac atctgtgccc
      361 ccagagaaga agacagctgt cgaagattca gggaccacag tggaaacaat taaactagga
      421 ggtgtctctt caacggagga attagacatt cgaacactgc aatcgaaaaa tcgtaagcta
      481 gcagaaatgc tagatcagcg gcaggccatt gaagatgagc ttcgggagca cattgagaag
      541 ctggagcgac gccaggccac cgacgatgcc tcactgttga tcgtgaaccg gtactggagc
      601 cagtttgatg aaaacatccg catcatcctt aaacgttatg atctggacca gggtttggga
      661 gacctactca cagaaaggaa agccttggtt gtgccagagc ctgagcccga ctctgacagt
      721 aatcaggagc gcaaagatga ccgtgagaga ggggaagggc aagagccagc tttctctttc
      781 cttgctactt tggctagcag ttccagtgag gagatggagt cccagcttca ggagcgcgtg
      841 gagtcctccc gccgtgctgt gtctcagatt gtgaccgtct atgataaatt gcaagaaaaa
      901 gtggatctct tgtcccggaa actgaacagt ggagataacc tgataatgga ggaagcagta
      961 caggagctga actccttcct tgcgcaagag aatgtgaggc tccaggaact gacagatctc
     1021 cttcaggaga agcatcacac catgtctcag gagttctgta agctgcaggg taaagtagag
     1081 acagcagagt cacgagtgtc cgtcttggag tccatgattg atgacctgca gtgggatatt
     1141 gacaaaattc gaaaaagaga acagcggctc aaccggcatt tggctgaagt cctagagcgg
     1201 gtgaactcaa aaggctataa agtgtacgga gcagggagca gtctctatgg aggcacaatc
     1261 accatcaatg cccggaagtt tgaggaaatg aatgctgagc ttgaggagaa caaagagttg
     1321 gctcagaacc gacattgtga gctagagaaa cttcgtcaag actttgaaga ggtcactaca
     1381 cagaatgaaa agttgaaggt ggagttgcgg agcgcagtgg aggaagtggt taaggaaacc
     1441 ccagaatatc gctgcatgca gtcacagttc tctgtcctgt acaatgagag tctacagttg
     1501 aaagctcact tggatgaagc tcggaccctg cttcatggca cccggggaac tcaccagcgc
     1561 caggttgaac tcattgagcg agatgaggtt agtctgcata agaagctgag aactgaagtg
     1621 attcagctgg aggatacctt ggcccaggtc cgcaaggagt atgagatgtt gaggatagag
     1681 tttgagcaga cccttgcggc caatgaacaa gcaggcccca taaaccggga gatgcggcac
     1741 ctcattagca gtctccagaa ccataaccac cagctgaagg gggaggtcct gaggtataag
     1801 cggaaactca gagaggcaca gtctgacctg aacaagacgc gtctgcgcag tggcagtgcc
     1861 ctcctgcagt cgcagtctag tactgaggac gccaaggatg aacccacaga gctgaagcaa
     1921 gactctgagg acctcgccac tcattcctca gcattgaagg cctctcagga ggatgaagtg
     1981 aagtctaagc gggatgagga agagagagaa cgagaaagga gggagaaaga aagagagaga
     2041 gaacgagaac gggaaaagga aaaggagaga gaacgagaga aacagaaact gaaagagtcg
     2101 gaaaaagaga gagatcctgt taaggataag gacaaaggga agcacgatga cgggaggaag
     2161 aaggaggcag agatcatcaa gcagctgaag actgagctca agaaagcaca agagagccag
     2221 aaggagatga agctgctcct ggacatgtac cgctctgccc ccaaggagca gagagacaaa
     2281 gtgcagctaa tggcggccga gaagaagtca aaggcagagt tggaggatct caggcaaaga
     2341 ctcaaggatc tggaagataa ggagaagaag gagaataaga aaatggctga tgaggacgcc
     2401 ttgaggaaga tccgggcagt ggaagagcag atcgaatacc tgcagaagaa gctggctgtg
     2461 gccaagcagg aggaagaagc tctcctgtct gagatggatg tcacaggaca ggcctttgag
     2521 gacatgcagg agcagaacat ccgtttgatg cagcagttgc gggagaagga tgatgcaaac
     2581 ttcaagctca tgtcagagcg gatcaagtct aatcagatcc ataagttgct taaagaggaa
     2641 aaggaagagt tagctgacca ggttttgaca ctgaagactc aggtagatgc ccagttacag
     2701 gtagtaagaa agctggaaga gaaggagcac ctgcttcaga gtaacattgg cacaggggag
     2761 aaggagctgg gtcttaggac tcaagcctta gagatgaata aacgcaaggc catggaggcg
     2821 gcccagcttg cagatgacct caaagcacag ctggaactgg ctcagaagaa gctccatgat
     2881 tttcaggatg aaattgtgga gaacagtgtc accaaggaaa aggacttgtt caatttcaaa
     2941 cgcgcacagg aagacatctc taggctccga agaaagctgg agacaaccaa gaagccagac
     3001 aacgtgccca aatgtgacga gattctgatg gaggagataa aggactacaa ggcgcggctg
     3061 acctgccctt gctgtaacat gcgtaaaaag gatgcagtac ttaccaagtg ttttcacgtt
     3121 ttctgctttg agtgtgtgaa gacgcgctat gacactcgcc agcgcaagtg tcccaagtgt
     3181 aacgctgctt tcggtgccaa tgatttccat cgcatctaca ttggctgagt gcagtcaaga
     3241 gagagaactg gctaggcaag cacttactca tcagtcacca ggcctctacc tctccctctg
     3301 tgacagctgg ccggctccct gctccccgga ctgtccaggt tctcttcgcc agtagccaga
     3361 gaacattcgt gaaaaagact gcaagtcttg gggtttagaa tgaactagaa gctactagtg
     3421 tttgtcttcc tatcagcttt ctttatgtcc tttcagagtt ttcagcattt tcttcttggg
     3481 caaagcctgt aaacttggat ttacccatcc tcctgaagaa gtcaggttga tggttttgac
     3541 actgagaagg gaatgtcata gagtgaacat atactattat ggagtagtga acttttagaa
     3601 ataagctatc gatgggcccc aaattcttga tttggtaata aacctttcta aacttaggtt
     3661 gtaaaatggt ataattgtga tagtctctcc tggaaggttc gaagccttaa tgaaattata
     3721 tccaggataa gtctatctct catttctagt aaactgactt tttgggtcag ttggacttct
     3781 tgctaaagtt atttatgttt taagtattca aatattaata ggtttttttt tttaatttct
     3841 taaggccaga atgatttcaa acatgatagt tcctatggtt ttgctttttg tttttttcct
     3901 cctgaaatca gacttagtac ttaagaagca gcaggaatgg attatgaaga gatctaggta
     3961 gtctaggata agatccagag agggttggtg aattatgaat tactgtcatc atcctctcag
     4021 agggactctt tgatttctgt tttccagaag attctcagta atgtttctgt aggattttaa
     4081 tattccatat actttcaatt aaagcaggat tcagctttc
//
LOCUS       NM_001015008            1236 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus transcription elongation factor A3 (Tcea3), mRNA.
ACCESSION   NM_001015008 XM_216552
VERSION     NM_001015008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Kwak,H. and Lis,J.T.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001015008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091180.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000005.1  153760407-153760578
            173-235             JAXUCZ010000005.1  153769363-153769425
            236-341             JAXUCZ010000005.1  153770246-153770351
            342-483             JAXUCZ010000005.1  153770944-153771085
            484-546             JAXUCZ010000005.1  153773557-153773619
            547-710             JAXUCZ010000005.1  153780542-153780705
            711-767             JAXUCZ010000005.1  153780847-153780903
            768-922             JAXUCZ010000005.1  153784770-153784924
            923-1069            JAXUCZ010000005.1  153788160-153788306
            1070-1141           JAXUCZ010000005.1  153791701-153791772
            1142-1236           JAXUCZ010000005.1  153792840-153792934
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1236
                     /gene="Tcea3"
                     /note="transcription elongation factor A3"
                     /db_xref="GeneID:298559"
                     /db_xref="RGD:1311369"
     exon            1..172
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    77..79
                     /gene="Tcea3"
                     /note="upstream in-frame stop codon"
     CDS             104..1150
                     /gene="Tcea3"
                     /note="transcription elongation factor A (SII), 3"
                     /codon_start=1
                     /product="transcription elongation factor A protein 3"
                     /protein_id="NP_001015008.1"
                     /db_xref="GeneID:298559"
                     /db_xref="RGD:1311369"
                     /translation="MGLEEELLRIAKKLEKMVARKKTEGALDLLKKLNSCQMSIQLLQ
                     TTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPRTTKGEREAREKAKKKEKGL
                     GSSGWKPEAGLSPPRKKEGGEPKTRRDSVDSRSSTTSSPKRPSLERSNSSRSKVETPK
                     TPSSPSTPTFAPAVCLLASCYLTGDSVRDKCVEMLSAALKAEDDFKDYGVNCDKLASE
                     IEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGTISPELIAKMTAEEMA
                     SDELRELRNAMTQEAIREHQMAKTGGTTTDLLRCSKCKKKNCTYNQVQTRSADEPMTT
                     FVLCNECGNRWKFC"
     misc_feature    116..1147
                     /gene="Tcea3"
                     /note="transcription elongation factor S-II; Region:
                     TFSII; TIGR01385"
                     /db_xref="CDD:273592"
     misc_feature    116..1147
                     /gene="Tcea3"
                     /note="transcription elongation factor S-II; Region:
                     TFSII; TIGR01385"
                     /db_xref="CDD:273592"
     exon            173..235
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            236..341
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..483
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            484..546
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..710
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..767
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..922
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1069
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1141
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1236
                     /gene="Tcea3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccggact cgagtgtccg gtgtgtttgc ggcccgtgcc gctcgcgctt tggcgcccgc
       61 tgctgccctg agcccctaac cccaccgagc gtcgtggacc aacatgggct tggaagaaga
      121 gctgctgagg atcgccaaaa aactggagaa gatggtggcc cggaagaaga cggaaggggc
      181 cctggacctt ctgaagaaac tgaacagttg ccagatgtcc atccagctgc tacagaccac
      241 caggatcgga gtcgctgtca atggagttcg caagcactgc tcagacaagg aggtggtgtc
      301 cttggccaaa gtcctcatta aaaactggaa gcggctgctg gattccccca gaaccaccaa
      361 aggagagaga gaagcaagag aaaaagcaaa gaagaaggag aaaggactcg gctcttcagg
      421 ctggaaacca gaagcaggtc tttccccacc aaggaagaaa gaaggaggag agcccaaaac
      481 caggagagac tccgtagact ccaggtcatc caccacctcc tctccaaaaa ggccttcgct
      541 ggaaagatcc aacagcagca gatctaaagt ggaaaccccc aagaccccca gcagcccctc
      601 aactcccaca ttcgcccccg ctgtctgtct cctggcctcc tgctatctca ccggggactc
      661 tgtccgggac aagtgtgtgg agatgctgtc agccgctctg aaggcggaag atgatttcaa
      721 ggactatgga gtcaactgtg acaagctggc ctcagaaata gaagaccata tctaccaaga
      781 actcaagagc acggacatga agtaccggaa ccgtgtgcgc agccgcatca gcaacctgaa
      841 ggaccccagg aacccgggcc tgaggcggaa cgtgctcagc gggaccatct ccccagagct
      901 cattgccaag atgacagccg aggaaatggc cagtgacgag ctgagggagc tgaggaacgc
      961 catgactcaa gaggccatcc gcgagcacca gatggccaag acaggcggta ccaccactga
     1021 cctcttgcgg tgtagcaagt gcaagaagaa gaattgtacc tataaccagg tgcagacacg
     1081 cagtgctgat gagcccatga ccacctttgt cttatgcaat gaatgtggga atcgctggaa
     1141 gttctgctga ctgaaccacc tgccaggaga ggaagacgga gcaggaagca cagaccccat
     1201 gacctggaac aaaataaaag ttcaaaagat ggaaaa
//
LOCUS       NM_053358               3076 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus single stranded DNA binding protein 3 (Ssbp3),
            transcript variant 1, mRNA.
ACCESSION   NM_053358
VERSION     NM_053358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Nishioka,N., Nagano,S., Nakayama,R., Kiyonari,H., Ijiri,T.,
            Taniguchi,K., Shawlot,W., Hayashizaki,Y., Westphal,H.,
            Behringer,R.R., Matsuda,Y., Sakoda,S., Kondoh,H. and Sasaki,H.
  TITLE     Ssdp1 regulates head morphogenesis of mouse embryos by activating
            the Lim1-Ldb1 complex
  JOURNAL   Development 132 (11), 2535-2546 (2005)
   PUBMED   15857913
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A. and Rome,L.H.
  TITLE     Cloning of a cDNA encoding a sequence-specific
            single-stranded-DNA-binding protein from Rattus norvegicus
  JOURNAL   Gene 237 (1), 201-207 (1999)
   PUBMED   10524251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced NM_053358.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107666.1, AF121893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               JAXUCZ010000005.1  126920187-126920601
            416-488             JAXUCZ010000005.1  126921562-126921634
            489-550             JAXUCZ010000005.1  126921854-126921915
            551-635             JAXUCZ010000005.1  126924241-126924325
            636-725             JAXUCZ010000005.1  127018017-127018106
            726-785             JAXUCZ010000005.1  127037215-127037274
            786-852             JAXUCZ010000005.1  127040034-127040100
            853-929             JAXUCZ010000005.1  127040190-127040266
            930-994             JAXUCZ010000005.1  127045623-127045687
            995-1043            JAXUCZ010000005.1  127046262-127046310
            1044-1079           JAXUCZ010000005.1  127046896-127046931
            1080-1134           JAXUCZ010000005.1  127047469-127047523
            1135-1205           JAXUCZ010000005.1  127048676-127048746
            1206-1284           JAXUCZ010000005.1  127054592-127054670
            1285-1313           JAXUCZ010000005.1  127055509-127055537
            1314-1415           JAXUCZ010000005.1  127055633-127055734
            1416-3076           JAXUCZ010000005.1  127056308-127057968
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3076
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="single stranded DNA binding protein 3"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
     exon            1..415
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="upstream in-frame stop codon"
     CDS             360..1445
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="isoform a is encoded by transcript variant 1;
                     sequence-specific single-stranded-DNA-binding protein"
                     /codon_start=1
                     /product="single-stranded DNA-binding protein 3 isoform a"
                     /protein_id="NP_445810.2"
                     /db_xref="GeneID:84354"
                     /db_xref="RGD:621502"
                     /translation="MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEI
                     RWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVL
                     GNIPPNDGMPGGPIPPGFFQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLLPNSMDP
                     TRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINMGPGAGR
                     PWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPP
                     GGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGISNPPGTP
                     RDDGELGGNFLHSFQNDNYSPSMTMSV"
     misc_feature    360..362
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); acetylation site"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    408..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Lissencephaly type-1-like homology motif; Region:
                     LisH; smart00667"
                     /db_xref="CDD:128913"
     misc_feature    600..1373
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    600..1373
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Single-stranded DNA binding protein, SSDP; Region:
                     SSDP; pfam04503"
                     /db_xref="CDD:461334"
     misc_feature    741..743
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); methylation site"
     misc_feature    759..761
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); methylation site"
     misc_feature    771..773
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); methylation site"
     misc_feature    777..857
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R050.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    909..1442
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R050.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1317..1319
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     misc_feature    1332..1334
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     misc_feature    1341..1343
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D032; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     misc_feature    1356..1358
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     misc_feature    1419..1421
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BWW4; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     misc_feature    1437..1439
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9R050.1); phosphorylation site"
     exon            416..488
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..550
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..635
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..725
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..785
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            786..852
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..929
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            930..994
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1043
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1079
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1134
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1205
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1284
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1313
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1415
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..3076
                     /gene="Ssbp3"
                     /gene_synonym="Ssdp; Ssdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagaccag cggcggcggc ggcagaggca gcggtgctga aggcgcagag ggcggcgcag
       61 gcggagccgg gtggcgggcg cgcgggccgc gagcaagcga gctgcaggct tcgggcgggc
      121 ggcggcgcag ctcaggccga gccggcgcgg gaggagttcc agggcgatgg ggccgcggcc
      181 ggggctgacg ctttgacagc tggaaagagc gcggagccag cgccggggag ggagggagcg
      241 cggcgagcgg agtgcgagcg agcgggcgag cgccgggagg gggccgggag cagggcagct
      301 cgggagaccg gacggtagcg gcggcggcgg cgggctcggc gccctcttct ctgcaagcca
      361 tgtttgccaa aggcaaaggc tcggcggtgc cctcggacgg gcaggctcgg gaaaagttag
      421 ctttatatgt ctacgaatat ttactgcacg taggagcaca gaaatctgca cagaccttct
      481 tatcagagat tcgatgggaa aaaaacatca cactgggtga accgcctggg tttctgcact
      541 cgtggtggtg tgtattttgg gacctttact gtgcagctcc tgaaaggaga gacacttgtg
      601 aacattcaag tgaagcaaaa gcctttcatg attacagtgc agcagctgcc ccaagtcctg
      661 tgcttggcaa cattcccccc aatgatggga tgcctggagg ccccatccca ccaggtttct
      721 ttcagccttt tatgtcaccg agatatgcag gcggccccag gcccccgatc agaatgggaa
      781 accagcctcc aggaggagtt cctgggacac agccattgct gcccaattcc atggatccca
      841 cacgacaaca aggtcacccc aacatgggag ggtcaatgca gagaatgaac cctccccgag
      901 gcatggggcc catggggcct ggcccacaga attacggcag cggcatgaga ccaccaccca
      961 actccctcgg ccccgccatg cctgggatta acatgggccc aggagctggc agaccctggc
     1021 ccaatcccaa cagtgctaac tcaatcccgt actcctcctc atcacccgga acctatgtgg
     1081 gaccccctgg tggtggcggc cctcctggaa cccccatcat gcctagtcct gcggattcaa
     1141 caaattccag tgacaacatc tacacaatga ttaatcctgt gccgcctgga ggcagccggt
     1201 ctaactttcc aatgggtcct ggctcagatg gcccaatggg cggcatggga ggcatggagc
     1261 cacaccacat gaatggatcc ttaggatcag gcgacataga tggacttcca aaaaattctc
     1321 ctaacaacat aagtggcatt agcaaccctc caggcacccc tcgggatgac ggcgagctgg
     1381 gggggaactt cctccactcc ttccagaacg acaattattc tccaagcatg acgatgagtg
     1441 tgtgatccct tctccacaac gctgagagcc ggcattgcag gcagaagatg ccagaaatta
     1501 tgcaagaaga agtgaggtgt cgataccagg agctggggga gggcgtctcc tgctcccctc
     1561 catccctccc attctctccc ccacctttcc caattttagt ttcatgcaat aaaaaggcca
     1621 aactttttat tccgtcaaac atgaaggaca aaactcagaa atatatttca agtcaacgac
     1681 cagaaaaatc tcaccttctc cctgcccaaa aggacctttc tgtacatgac actttttgtt
     1741 gggttttttt gtttgtttgt ttgtttgttt gtttgggatt ttactgttgc tgggatttta
     1801 aatttgtttt tttgggggga ttctttgggg gaattttttt aatggaagct tctagcaagc
     1861 cctatgccca cccaatcaac ctcattgctt tcttctttaa taaaaggaaa aaaggaaaaa
     1921 gaaaaaaaag gccaaaaaaa aaaaaaaagg aagaaaaacc cacaagccct gctgtctatc
     1981 cccaagtcct accaccagaa aagctagtct aggtgtgcaa tatcacactg atgttgtagc
     2041 catctaaaaa taataataat aaactggaca gtttacaatt ggtggtttct ttcaaaagct
     2101 gtttggggag aaggaactga agtcaacggt ttccacgtgg gcctttgggg tttgtgctgg
     2161 gcaaggagat gcaggtgtcc actttgctct ggctgggctg gccatcacaa cacactgggc
     2221 cagaggaccc agagccccca acttgccgtc acccaacaga gaccatcgct gtgacccagc
     2281 gtacacactg ttccaggatg gctgcctctt ctccaaacct ctcatgccca gccacagggg
     2341 cctccagtcc ctcggtcccc accgtttcct ggcaagaatc ctgctggctg ggtagtggcc
     2401 caggctgtgt aggagaggcc ccaccaacag gatgactaca atctgggcca tagaactgac
     2461 ctccatgttc tggtcccgag ctcctcacat agtgcgcact ggcagggcgg gctgaagttg
     2521 tgtttttctt tttttctcct gtttgtcctt tttcaaagat gggtgttggt tggaattgct
     2581 ctgtatttgc ttggaactgg atggacagac ttcagcattg ctgtggggtg gggggagcac
     2641 cagcaaccaa acagacactg tttctggtcc tgtttttatt ttcaaaaact gatgaacctg
     2701 atggtggagc ctgtcccctc tgaggagggg tgacttggct gccctggcct ctccccgtgg
     2761 caaccattgt gtcttgctcc ggaagacact gagttctttg tacatttacc ccctctgtgc
     2821 cccgcccatc ctcgtagctg gtctttgttt tcttacctcc cctttctgac ccatgtatat
     2881 catattatgt gagataccat ctgcctgaca aaagacttgt gcggatcctt gggaacattg
     2941 tagctgtttc tgtgtttttt cttaccttgt agtctggttc tgaattatga gaggaaaaaa
     3001 agtaattatg atacattgta gtttgtgtac gatatatgtt gataacgttt tattaaaggg
     3061 acatcttttt tccgca
//
LOCUS       NM_001106061            3639 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 3
            (Arhgef3), transcript variant 5, mRNA.
ACCESSION   NM_001106061 XM_001055379 XM_224588
VERSION     NM_001106061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 20, 2025 this sequence version replaced NM_001106061.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.49700.1,
                                           SRR26360186.1447654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000016.1  2519197-2519424
            229-336             JAXUCZ010000016.1  2546487-2546594
            337-507             JAXUCZ010000016.1  2562094-2562264
            508-570             JAXUCZ010000016.1  2566684-2566746
            571-667             JAXUCZ010000016.1  2568438-2568534
            668-744             JAXUCZ010000016.1  2568687-2568763
            745-1002            JAXUCZ010000016.1  2576216-2576473
            1003-1173           JAXUCZ010000016.1  2582072-2582242
            1174-1360           JAXUCZ010000016.1  2584906-2585092
            1361-3639           JAXUCZ010000016.1  2586356-2588634
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3639
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
     exon            1..228
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1710
                     /gene="Arhgef3"
                     /note="isoform 3 is encoded by transcript variant 5; Rho
                     guanine nucleotide exchange factor (GEF) 3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 3 isoform
                     3"
                     /protein_id="NP_001099531.1"
                     /db_xref="GeneID:290541"
                     /db_xref="RGD:1310672"
                     /translation="MVAKDYPFYLTVKRANCSLEAPLGSGVAKDEEPSNKRVKPLSRV
                     TSLANLIPPVKTTPLKRFSQTLQRSISFRNESRPDILAPRAWSRNATSSSTKRRDSKL
                     WSETFDVCVSQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQ
                     ELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQV
                     AAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHT
                     PNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVL
                     CCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGE
                     VRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV
                     LSAAGQAGLLDSESLSQSPGTENRELRGETKLEQMDQSDSESDCSMDTSEVSLECERM
                     EQTDASCANSRPEENV"
     misc_feature    508..1038
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    508..1038
                     /gene="Arhgef3"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1078..1476
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     misc_feature    1078..1476
                     /gene="Arhgef3"
                     /note="Rho guanine nucleotide exchange factor 3 Pleckstrin
                     homology (PH) domain; Region: PH_RhoGEF3_XPLN; cd10572"
                     /db_xref="CDD:269976"
     exon            229..336
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..507
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..570
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..667
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..744
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1002
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1173
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1360
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..3639
                     /gene="Arhgef3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctgctag aagccgttgt aggtgttcgc gtcgccgccg ccggcatcgt ggagctcggg
       61 ccctctttta cccgggattt ttgttgtcgc ctgggatcag cggtgacatc gcaaagggca
      121 ggcccggcag ctgccatggt ggccaaggat taccccttct acctcactgt caagagggca
      181 aactgcagct tggaggcgcc cctgggcagc ggggtggcca aggacgagga acctagtaac
      241 aaaagggtca aacccctttc cagagtcaca tcgctagcaa acctcatccc acctgtgaag
      301 accacaccgt taaagcgctt cagccaaacc ttgcagcggt ccatcagctt ccgcaatgag
      361 agccgccccg acatcctcgc ccctagagcc tggtccagaa atgccacctc ctcaagcacg
      421 aagcggaggg acagcaaact ctggagtgag accttcgatg tgtgtgtcag tcaggtgctc
      481 acagccaagg agatcaagag acaggaggca atttttgagc tttctcaagg tgaagaggat
      541 ttgatagagg acttgaaatt agcaaaaaag gcctaccatg accccatgct gaaactctca
      601 ataatgacag aacaagagct gaatcagatt tttggaacac tggactctct aatccctctc
      661 catgaagacc tccttagtca gcttcgagat gttcggaagc ccgatggctc gacggaacac
      721 gttggtccca tcctcgtggg ctggctgcct tgtctcagct cctatgacag ctactgcagc
      781 aatcaagttg ctgccaaagc cctgctggac cacaagaagc aggaccacag agtgcaggat
      841 ttcctccagc gctgcttaga atcacccttc agccgcaaac tcgacctctg gaatttcctt
      901 gatattcccc ggagccggct agtgaagtac cctctgctcc ttcgagaaat cctgaggcat
      961 acgccaaacg ataatccaga ccagcagcac ctggaagaag ctataaacat cattcaggga
     1021 attgtggcag aaatcaacac caagactggg gaatcggaat gccgttatta caaagagcgg
     1081 cttctttact tggaagaagg ccagaaagat tccctgattg acagctcaag ggtcctgtgt
     1141 tgtcatggag agctgaaaaa taaccggggt gtgaaactcc atgttttcct gttccaagaa
     1201 gtgctggtga ttactcgagc tgtcacgcac aatgagcaac tctgctatca gttgtaccgg
     1261 cagcccatcc ctgtgaagga cctcactctg gaagacctgc aggatggaga agtgcggctg
     1321 ggtggctccc tgcgtggggc cttcagcaac aatgagagaa ttaaaaactt cttcagagtc
     1381 agtttcaaga acggatccca aagtcagacc cactcactgc aagccaacga caccttcaac
     1441 aaacaacagt ggctcaactg tatccgtcag gccaaagaaa cggttctgtc tgctgccggg
     1501 caggctggct tgcttgactc cgagagcctg tcccagagtc ctggcactga gaacagggag
     1561 ctgcggggag aaacaaaact tgagcagatg gaccaatcgg acagtgagtc ggactgcagt
     1621 atggacacaa gcgaggtcag cctcgaatgc gagcggatgg aacagacaga cgcttcctgt
     1681 gcaaacagta ggcccgagga gaacgtctga cagaggctgt gaccctgcca gcagcaggcc
     1741 cgtgtcttac ctgtacagtg tttgtattcc acacgggaac agtttggaga ggcactttgt
     1801 aatactcctg tgcctgtgtt ggcctagccc ctgtgtctac tccttgtccc tagcactgta
     1861 actgccaccc agtctgtgtc agcttgcagc agcccttacc ctgttgctgt atcccacaag
     1921 catctggatg agtgcggagg aatggaccat gttacttcga gttgtcctac attcaaaaca
     1981 gaaagactct ctaaactact gttgtgcatg gcaaggcctt tgtctcatgc ttgcctagtg
     2041 ttcctctagc tctgacatag tcgctgaagt cctggcactg ggagagctct gcagaatact
     2101 gagatcgcat tgaagggaag gcagaaagtc tgattaaccc ttggagggaa ctccagtttt
     2161 gagttaattc aactagaaag catgaaaagc atctctgggg gtttctgagg ttggattttt
     2221 gcaaaggagg aagccttgtt ttgaagcctg tggtttcatc cagtgcaagt tgaatgtgaa
     2281 taatctgtga agacctgaaa cagaggtggc tttagaaagg gccaagacaa gagcagctgc
     2341 cggacaggca agcagaggca ggaagatgcg gagttcaaga acagccttgg ctacttacca
     2401 aattctagtt caaactgaat tccaccgtaa aaacaaaaca aagctaaaag caccagccag
     2461 ctctgaatat tcagctgaag ttgggggtgg atattggagg cgtttgtcat ggccaatggc
     2521 ttgccattag aagagccctt tctagcctac aacatcagga ttgccaggac cagagaagat
     2581 ctgccagggt catgtgaccc catcagcatt atgtttcatc ctcctcagcc actcctcttt
     2641 tccagtggta atagggggct gggggatagg gacacagaga ctgtgactgc atccagtgac
     2701 tgttgacaaa caagagagaa ggacttgggg gtgagaaatg tgtcactgtc acccaaggct
     2761 cctgcgtgaa ccacagaaat tgaagttact ccggagggtc tcaagatttc ctgctctgct
     2821 tttgggcctg gttctagagc tacagacgga ctggtggtta attcccctcg aggctggttt
     2881 cattagctct tattaactag aaccggctag ccaaactgga aagttctttg ttaaagcctt
     2941 gctttacaga gcaaggatgg gtaaaaagac cttgagggcg tggtggaaaa aaccgttcac
     3001 aaactagaca gagcagcttc tgcaagtgta aatacttaga ggatttgtat aaaattatac
     3061 ccacaccagc actagtagta atgattctaa attattgcca aaaagttttt tttgtttgtt
     3121 gttgttaatt tttgcatcta tcaaaagttt acagaaaaga aagcaaaatg caaagttgtc
     3181 cctttactat gcacatgtgt cgtgcgcact gaaagaagcc gtgtggcaag agcaaccaat
     3241 agaaaaacaa ggtatatgac attattattt ttcaagacct attttgacca gtttctaccc
     3301 tgtaaagcct atttctgtat ttatagtttt taaccatggt gaaaattttt ttctattatg
     3361 agtttattta aaaccatttt gtctctcaag ttgctgatgt agcgaataaa cctgctccgg
     3421 gcagacacag taggaagctg agacggaccg ggcactggac gatagagaaa agcctgaaat
     3481 gttctctaca gagccattgt gaccagcgag ttaaggaagg gtctctgtca gggtcagcct
     3541 gtgggaagag agtgaatgaa tgttctggtg aaatgaatac ttttgtataa tggccttaaa
     3601 cttttctgga agcatttcaa ataaattgca ttaagaata
//
LOCUS       NM_001436805            4664 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus cilia and flagella associated protein 97
            (Cfap97), transcript variant 1, mRNA.
ACCESSION   NM_001436805 XM_063275427
VERSION     NM_001436805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 21, 2025 this sequence version replaced XM_063275427.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50596.1,
                                           SRR26643293.74849.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000016.1  52856873-52857039   c
            168-1264            JAXUCZ010000016.1  52848306-52849402   c
            1265-1533           JAXUCZ010000016.1  52836572-52836840   c
            1534-1684           JAXUCZ010000016.1  52822585-52822735   c
            1685-4664           JAXUCZ010000016.1  52818692-52821671   c
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..4664
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
     exon            1..167
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            168..1264
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1812
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 1"
                     /protein_id="NP_001423734.1"
                     /db_xref="GeneID:306469"
                     /db_xref="RGD:1307325"
                     /translation="MDRFGDISEGEVDHSFFDSDFEDTKKCESNSIFDKQNDDDFKEG
                     INKDIKNLNLKFGVQNDNLKEKIDNDTENVNVKLGIQTKENYLTQKGNERKPKFPSKE
                     QHVENDPIQTRSPSLLTSSRSKKLCDTTKGNKLHLPVPNRIPKIVKGEDDYYTDGEES
                     SDDGKKYHVRSKSAKPSSNLKKNNTSKKYSKASSSSLSSSSSRSSSDCSDIGSDMQNK
                     PDSGSSGKRVSSVTPSSPKQKCKSGRKSSAKQKAGDYNAESEDNVTDVTPASTPDSSP
                     AQPFELSQSQNQKVKVKRQENVSRDVYEDVEALKNDSRCLKSAKRKEKHGQNFAPKSS
                     VLDANLDRRSKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFEQPSIIPRKNYSFTREE
                     VRQIDRENQRLLKELSRQAEKPGNKSTIPGRSLGHPPKLYHSALNRQREQQRIERENM
                     ALLKRLEAVKPTVGMKRSEQLMDYHRNISYLNPSPSVRRVRSTLGHYSPLRGASRTSS
                     ATSGLSCKTDRSVLDTSSGFLLRPKPPNVRTAWL"
     misc_feature    205..207
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    238..240
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    436..1074
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    646..648
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    661..663
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    664..666
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    886..888
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9P2B7; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    958..960
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H34.1); phosphorylation site"
     misc_feature    1246..1554
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1246..1554
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    1402..1476
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H34.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1265..1533
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1684
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..4664
                     /gene="Cfap97"
                     /gene_synonym="RGD1307325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaacccga acgctcggcg cggcgcgaga gtcggtagcg gccacagttc ccaggtgagc
       61 ggctcacggg cttccgcatc cggtcggtct ccagcgggcg agacgccctc ctctgcgttc
      121 ggggtccgtt tccccggttc ggtgcccgac ggaggcgagc acccaggata tacttttggc
      181 atcatggatc ggtttggcga tatctcagaa ggtgaagtgg accattcttt ctttgacagt
      241 gattttgaag acacaaagaa atgtgaaagt aattccattt ttgacaagca aaatgatgat
      301 gactttaagg aaggaataaa taaggacatc aaaaatttaa acttgaaatt tggagtacaa
      361 aatgataacc ttaaagagaa aatagataat gacacagaaa atgtgaacgt gaaacttggg
      421 atacaaacaa aggaaaatta ccttactcag aagggaaatg aaaggaaacc aaaatttccc
      481 tcaaaggaac aacatgtaga aaatgaccct atacaaacaa gaagtccctc attgttgact
      541 tcttcaaggt caaaaaaact gtgtgatacc acaaaaggaa ataaactaca tttgcctgtt
      601 ccaaatagaa ttcctaaaat tgtgaaaggt gaggatgact actacacaga tggagaggaa
      661 agcagtgacg atgggaagaa gtaccacgtg aggtctaagt cagcgaagcc ctctagtaac
      721 ttaaaaaaga acaacacaag taagaagtat tccaaagcca gttcctcctc tctgtcttcc
      781 tcatcttcac gatcaagctc agactgctca gatataggat ctgacatgca aaataaacct
      841 gattcaggtt catcagggaa acgagtttct agtgtaaccc cctcatcacc aaagcagaag
      901 tgtaagtcag gaagaaaatc aagtgctaaa cagaaggcag gtgactataa tgcagagtca
      961 gaagacaacg taacagacgt aactcccgcg tcaactccag acagcagccc tgcccagcca
     1021 tttgagttga gccaatcaca gaatcaaaaa gtaaaagtta aaagacaaga aaatgtgagc
     1081 cgggatgtgt atgaggatgt ggaggcttta aagaatgatt caagatgtct gaaatcagcc
     1141 aaaaggaaag aaaagcatgg acagaatttt gctccaaaat catcagtgtt agatgcaaat
     1201 ctagaccgta gatccaagca aaaagtctta catgacacaa tggaccttaa tcatctgttg
     1261 aaagctttcc tgcagttaga taaaaaggga ccacagaaac atcactttga gcagccttca
     1321 ataataccta ggaaaaacta ctctttcaca agagaagagg tgagacagat tgatcgggag
     1381 aatcagaggc ttttgaaaga actgtcaaga caggctgaaa aaccaggaaa caaaagtaca
     1441 attcctggaa gatcgctcgg ccatccacct aagttgtatc acagtgctct caacagacag
     1501 agggaacagc aaaggattga aagagaaaat atggctttat tgaaacggct tgaagctgtg
     1561 aagccaacag ttggcatgaa acgctctgaa cagctgatgg actaccatcg gaatatcagt
     1621 tacctcaacc cttcaccgtc cgtcagacga gtgagatcta ctcttggcca ttacagccca
     1681 ctgagaggag cttccaggac atccagtgca accagtggtc tcagttgtaa gactgatcga
     1741 tcagtgttgg acacatccag tggctttttg ctaagaccga aacccccgaa tgttcgtact
     1801 gcttggttgt aaaacctttt tttatgatat acattgttca tctgttggtc ctgttttaac
     1861 gatgtatttt tctgtactac tataactatt tgcaaacatc tgtcatactt ttccaacaat
     1921 ttatacagca atgagtataa tttattgtta ttcagtgcaa attgttatca aaagacactt
     1981 tgatgtaaaa tcagtgtttc atgcagtggc atatttatag gagccatatg tctatttcat
     2041 agagaaaggt gtatgcatga atgtttcttc gatataggaa ttcagctgtt gtgctgacaa
     2101 agcagcagtg gtggtaatcc atgttgaaac caagacgctc actatatagt tcttaatcta
     2161 tatgagtttc agttattgta agcgttaagg tgctttacct tgtaaactta agcgcctcat
     2221 gcttctgtct gctttagact gtctgtaaca cgagtcagca cttgcttatg tgagtgttcc
     2281 actccaaatg aaaaaaactt gaaatttgtt ttcatggaga agctggtgta gtcttgatga
     2341 ggagcatgag cagcttgtat cagtgcagct cttgcttgac taacgacgct tctccctaag
     2401 tctgattatc tattccaaac cgtttcaccc catgaatgag gggttcactt tagaagcgtc
     2461 tgtttcatgt ttatatgcag tctggtaaaa tacccttaag gattctgagg caagagagag
     2521 gctttaacag cttcgagtct tgtgacttgt gactggtttg gatccagatc atttgcatca
     2581 ttaacaaaag catgtgttta tggatcaggg agcaacattc ccagcttgaa gaccagggtg
     2641 tgttagagca gtgtttgaaa tgatactgtt agtgtgtgtg ctgtcgttgt gtatttattg
     2701 tattaataga atgcttagag taaggaagaa atgattagag aaaccaaata caaacaagaa
     2761 agaaactaat cacacattgg tcacagctac tgccttaatg ttagtgaatg tccttggctt
     2821 gctttagctg agtcctggaa gcaccagtct tcagtctcat gtttgaaggt ctgttaatcc
     2881 tcatggactt gctagtgacc cacagatgtg aaatagttga ctatgaaaaa ctagaatatt
     2941 ttcctgtcaa cctagaggct gttcttttgt agaacaaagt gtgtgatatt tcatagtcat
     3001 agcctttcat tgctggtctt gtcagtatgc ctttagtaaa taccttttat attcaatgac
     3061 acgcttttct taaaatatga attttccctg accacagaga gatctgtctg gttcagtgct
     3121 cagcactgga gcatgtgggc cacacctgct tcgccttccg tagcagggag gccgactgcc
     3181 cttaccaagc accaggtcac acattgttag tctcacttta atggatggtg ttccagatag
     3241 agcagtgatg gtaggaaatg gtgagaccac aacaatgctg atatacatag catacacaca
     3301 catacactct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     3361 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgactaaggg
     3421 tttttctgct gcttttggag gactgtaaca ttctataaca atttatttct ttgttttagt
     3481 gaacaagatt ttgtacctgc tctatatacc ccttttaatg tttttgtaac aacttaaatt
     3541 taaaatgcaa cattttggca tttgctcagt agtgaatcac tttaaagcag atttttgtgg
     3601 gaaaaaaact tgtatatgta aaaccttcta tgttcacagt ggcattagcc taggcacatt
     3661 tttgttggtc tctccaagtt ccatagataa actagaattt gattttaaat gctaatttat
     3721 gtcttagttt ttactgtttg gaagaagttt aactaagtgt tactgatgac aaggattcaa
     3781 cctcaagtaa agggcaacca tcttttaaaa gcaatttagc ttgttatatt gtaggtgcat
     3841 agatctggtg actgtagaga tgggtaggag ttatactcag aactcactga tggacgtcaa
     3901 ggtactgtta ggtaggatta ggaagccttt gcaatggagg agtcatgagt acattaatct
     3961 cttcagcctc accaacacaa acatgtactc ttagcactgt tgcatggttg gctggctggt
     4021 ccttaccaag catacttgga aggcccacat ctgtagctag aaagcgtgct ggtctgctgc
     4081 ctagagacag atctgagaac tgttttcatc tctgtcaaat gttatctcct tttctagtaa
     4141 gtttttgtga gatttcaaat tattaaaatt acttcttaag gagtagctac tacctcatcc
     4201 tccccaactg actctttcag tccccatcaa aacctgctct aactgctatt ccagttaaca
     4261 ctctatggct tgcttgttta ataacatcat gcacttgtgc tcaacccaag tatcagaaac
     4321 gcgactcgcg gctttgagag gtgattgtga taggtctgct tctcatctgc agatacaatg
     4381 cagcaactcc aaagtattaa gatcacacta agctgaagat gcacctttgc cctggttagc
     4441 aacgcaaaac cgtatcgtca tacatgccaa ggccttagcg tgtagatgtc tgtacaccgg
     4501 cacagcgaat gagctcactg ctaatggctg agttgcttat tttcatgaac aaagattagc
     4561 aagaaactgt taaaccatct ttttaaaaac tgttctagtt tgtcatattt taggcatgaa
     4621 gaactagctt ggcttactga agaaataaaa gatttaaaga gaac
//
LOCUS       NM_001436896            2129 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus nephrocystin 4 (Nphp4), transcript variant 3,
            mRNA.
ACCESSION   NM_001436896
VERSION     NM_001436896.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Borgal,L., Habbig,S., Hatzold,J., Liebau,M.C., Dafinger,C.,
            Sacarea,I., Hammerschmidt,M., Benzing,T. and Schermer,B.
  TITLE     The ciliary protein nephrocystin-4 translocates the canonical Wnt
            regulator Jade-1 to the nucleus to negatively regulate beta-catenin
            signaling
  JOURNAL   J Biol Chem 287 (30), 25370-25380 (2012)
   PUBMED   22654112
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   French,V.M., van de Laar,I.M., Wessels,M.W., Rohe,C.,
            Roos-Hesselink,J.W., Wang,G., Frohn-Mulder,I.M., Severijnen,L.A.,
            de Graaf,B.M., Schot,R., Breedveld,G., Mientjes,E., van
            Tienhoven,M., Jadot,E., Jiang,Z., Verkerk,A., Swagemakers,S.,
            Venselaar,H., Rahimi,Z., Najmabadi,H., Meijers-Heijboer,H., de
            Graaff,E., Helbing,W.A., Willemsen,R., Devriendt,K., Belmont,J.W.,
            Oostra,B.A., Amack,J.D. and Bertoli-Avella,A.M.
  TITLE     NPHP4 variants are associated with pleiotropic heart malformations
  JOURNAL   Circ Res 110 (12), 1564-1574 (2012)
   PUBMED   22550138
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Hoefele,J., Wolf,M.T., O'Toole,J.F., Otto,E.A., Schultheiss,U.,
            Deschenes,G., Attanasio,M., Utsch,B., Antignac,C. and
            Hildebrandt,F.
  TITLE     Evidence of oligogenic inheritance in nephronophthisis
  JOURNAL   J Am Soc Nephrol 18 (10), 2789-2795 (2007)
   PUBMED   17855640
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Arts,H.H., Doherty,D., van Beersum,S.E., Parisi,M.A.,
            Letteboer,S.J., Gorden,N.T., Peters,T.A., Marker,T., Voesenek,K.,
            Kartono,A., Ozyurek,H., Farin,F.M., Kroes,H.Y., Wolfrum,U.,
            Brunner,H.G., Cremers,F.P., Glass,I.A., Knoers,N.V. and Roepman,R.
  TITLE     Mutations in the gene encoding the basal body protein RPGRIP1L, a
            nephrocystin-4 interactor, cause Joubert syndrome
  JOURNAL   Nat Genet 39 (7), 882-888 (2007)
   PUBMED   17558407
REFERENCE   8  (bases 1 to 2129)
  AUTHORS   Hoefele,J., Sudbrak,R., Reinhardt,R., Lehrack,S., Hennig,S.,
            Imm,A., Muerb,U., Utsch,B., Attanasio,M., O'Toole,J.F., Otto,E. and
            Hildebrandt,F.
  TITLE     Mutational analysis of the NPHP4 gene in 250 patients with
            nephronophthisis
  JOURNAL   Hum Mutat 25 (4), 411 (2005)
   PUBMED   15776426
REFERENCE   9  (bases 1 to 2129)
  AUTHORS   Hoefele,J., Otto,E., Felten,H., Kuhn,K., Bley,T.A., Zauner,I.,
            Hildebrandt,F. and Neumann,H.P.
  TITLE     Clinical and histological presentation of 3 siblings with mutations
            in the NPHP4 gene
  JOURNAL   Am J Kidney Dis 43 (2), 358-364 (2004)
   PUBMED   14750102
REFERENCE   10 (bases 1 to 2129)
  AUTHORS   Otto,E., Hoefele,J., Ruf,R., Mueller,A.M., Hiller,K.S., Wolf,M.T.,
            Schuermann,M.J., Becker,A., Birkenhager,R., Sudbrak,R.,
            Hennies,H.C., Nurnberg,P. and Hildebrandt,F.
  TITLE     A gene mutated in nephronophthisis and retinitis pigmentosa encodes
            a novel protein, nephroretinin, conserved in evolution
  JOURNAL   Am J Hum Genet 71 (5), 1161-1167 (2002)
   PUBMED   12205563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1094807.1,
                                           SRR26643299.25723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  168270670-168270849
            181-361             JAXUCZ010000005.1  168277437-168277617
            362-514             JAXUCZ010000005.1  168282813-168282965
            515-687             JAXUCZ010000005.1  168290128-168290300
            688-752             JAXUCZ010000005.1  168291652-168291716
            753-908             JAXUCZ010000005.1  168292620-168292775
            909-1045            JAXUCZ010000005.1  168297120-168297256
            1046-1227           JAXUCZ010000005.1  168300379-168300560
            1228-1354           JAXUCZ010000005.1  168301228-168301354
            1355-1537           JAXUCZ010000005.1  168309203-168309385
            1538-2129           JAXUCZ010000005.1  168311674-168312265
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2129
                     /gene="Nphp4"
                     /note="nephrocystin 4"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
     exon            1..180
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            181..361
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    209..211
                     /gene="Nphp4"
                     /note="upstream in-frame stop codon"
     CDS             227..1573
                     /gene="Nphp4"
                     /note="isoform b is encoded by transcript variant 3;
                     nephronophthisis 4 (juvenile) homolog"
                     /codon_start=1
                     /product="nephrocystin-4 isoform b"
                     /protein_id="NP_001423825.1"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
                     /translation="MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIK
                     QGILDMLSELECHLRVSLFDVTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHT
                     TLSHPSIVAVIEVVAEGRKRDGALQVLSCGFGILRIFGNKPESPTSAGQDKRLRLYHG
                     TPRALLHPLLQDPIEQNRYMTMMENCSLQYTLKPHPPLEPAFHLLPENFLISGLQQIP
                     GLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLEKFEEELVQLLISDHFREGVG
                     LLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRSASFSRRITASSKSS
                     SGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLSSLACMHMV
                     RWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEESVFGCIPIIRH"
     misc_feature    389..>1528
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     misc_feature    389..>1528
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     exon            362..514
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..687
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..752
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..908
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1045
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1227
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1354
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1537
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2129
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagtgag cggtatccct caggtcggga ctcctcgcgt gggtggcggc ggattgggcg
       61 accccctgga ccagcactgg atccacgaga cctcgggttc cgctgggcac cggcagcccg
      121 atcgctggat ccacggtgcg ggacctgttc cgtagcgtgg atctcgtgcc cgtctcctag
      181 atggtgcagg gagtcccgga gacccacgtg aggttggaca ggcagcatgg atgactggca
      241 cagagccttc acccagaaca cactggtccc tccccacccg cagagagcgc ggcagtttgg
      301 gaaggagtcc acggcgttcc agtgcatcct gaagtggctt gatgggccac tcattaagca
      361 gggaatccta gacatgctgt ctgagcttga atgccacctg cgagtgtctc tcttcgacgt
      421 cacctacaaa catttcttcg ggaggacgtg gaaaaccaca gtgaagccca ccaatcagct
      481 ctctaagcag ccacccagga tcctcttcaa tgagcccttg tacttccaca caaccttgag
      541 ccaccccagc atcgtggctg taatagaagt ggtcgctgaa ggcaggaaga gggacggtgc
      601 cctgcaggtg ctgtcctgtg ggtttggaat tcttcgaatt tttggcaata agccggaatc
      661 tcccacctct gcaggccagg acaaacggtt gaggctgtat catggtaccc ccagagccct
      721 tctgcaccca cttctccagg atcccataga acagaacagg tacatgacaa tgatggaaaa
      781 ctgtagcctg cagtataccc tgaagccaca cccgcccctg gagcccgcct tccacctgct
      841 ccccgagaac ttcctgatct ccggtctcca gcagatccct ggcctcctcc cacctcatgg
      901 agacacgggt gatgccctga ggaagcctcg cttccagaag cccaccacat tgcacctaga
      961 tgacctcttc ttcaccctgt acccctccct ggagaagttt gaggaggaac ttgtgcagct
     1021 gctcatcagc gaccacttcc gggagggggt tggcctgcta gatagcggca ccctagaggt
     1081 cttggagcgg cgcctgcatg tctgtgtcca caacggtctg ggcttcgtgc acaggccaca
     1141 ggtggttgtg cttgtacctg agatggacat gaccttgacg cgctcggcca gcttcagcag
     1201 gagaatcact gcctcttcta agagcagctc tggaaatcag gctctggttt tgagaagcca
     1261 cctgagactc ccggagatgg tcaatcaccc atcgtttgcc atcgtcttcc agctggagta
     1321 cgtgttcaac agcccctcag gagcggacgg cagtgccagc tcatccacct ctctgtccag
     1381 cttggcgtgc atgcacatgg ttcgatgggc tgtttggaac cccgatctgg aagcaggccc
     1441 gggaaaggtg acgctgcctc ttcagggtgg ggtacagcac aacccctcac gatgtctggt
     1501 ctataaggtg ccttcggcta gcatgagctc tgaggagagt gtgtttggct gcatccccat
     1561 catccgccac tagatgtcag tggagtcccc agttgtggct gcaagcatct acagaccttg
     1621 ctgaaggctt tttgggccag aagtgcctgt ggttgaggac cagcaccctg agcagacatc
     1681 gtgaatgaca gcagtgtgat gtcgtgggac ctgctctgtc tctgctcctg cgctgggaaa
     1741 gcaccatggc ttctctgcga gtttcttcct ggtgtctcca accctggcca agtcggacca
     1801 gctggaatgg gggtgtgcct tacccatgcc ctcgcccagc gggctctgcg gacctttgga
     1861 cactgagagg gaagctgagc agaaatggca gctgccagtc ggggaaaaca gcactcatgg
     1921 agaagctgca ttgtttctgg gaagctgttc tggggctcat gttgcccact gttatttcac
     1981 tgtttgccgt gaagcaagcc tccatctcat gccgtgtttc cttttcttgt ctcgtccttt
     2041 tcctttggat gaataattct ttaaaagtat ttctatctcc agaagcctgc acttccagct
     2101 cctggctgtg atttacagtt atttacctc
//
LOCUS       NM_001436945             514 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 13, mRNA.
ACCESSION   NM_001436945
VERSION     NM_001436945.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 514)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 514)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 514)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 514)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 514)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 514)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 514)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2002041.1,
                                           SRR26360190.74433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000005.1  61741152-61741221   c
            71-514              JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..514
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..70
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..227
                     /gene="Ccl27"
                     /note="isoform g is encoded by transcript variant 13; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform g"
                     /protein_id="NP_001423874.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MWRRERSSAHPREQKLEPLRGLMSCLSSGLRPAPQRSGRGLLCR
                     TPTAAAQTAGALKI"
     exon            71..514
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctttgcag gatctactgg ggctgcttct acttttttcc ttggctgcga atgtggcgca
       61 gggagcggag ctcggcgcac ccccgggagc agaagctgga gcctctgcgg ggcctaatga
      121 gctgtttgtc gagcggcctg aggcctgctc cccagcgctc aggtcgcggt ctcctctgtc
      181 gcacccccac cgctgctgca cagacagccg gtgcattaaa gatttaaagt cacgcccact
      241 gccttcctga ctttaccgcc gcagccgcca ctggtgctgg gaatcccact ccacacctgc
      301 tgtttcttag cccacagggc atccctccct ggtaggaagc ccttgcatgt ctaagcctcc
      361 aatgtcccta aaggtcaagc tgccaattac tatcagtgac tggctccctg ccacgccctc
      421 cccaaaagca cccacactga gagtgtaggc cacatctgtc caccacttcc cagtattccc
      481 acaacttcag ctattaccat cttcctctag ccgt
//
LOCUS       NM_001436856            3174 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 6, mRNA.
ACCESSION   NM_001436856 XM_063287789
VERSION     NM_001436856.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287789.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.704735.1,
                                           SRR26360186.1852656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000005.1  155719734-155719766
            34-222              JAXUCZ010000005.1  155724378-155724566
            223-322             JAXUCZ010000005.1  155724942-155725041
            323-476             JAXUCZ010000005.1  155726205-155726358
            477-636             JAXUCZ010000005.1  155728962-155729121
            637-780             JAXUCZ010000005.1  155732660-155732803
            781-858             JAXUCZ010000005.1  155734814-155734891
            859-1010            JAXUCZ010000005.1  155735359-155735510
            1011-1101           JAXUCZ010000005.1  155738870-155738960
            1102-1261           JAXUCZ010000005.1  155740995-155741154
            1262-1373           JAXUCZ010000005.1  155742543-155742654
            1374-1490           JAXUCZ010000005.1  155743955-155744071
            1491-3174           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3174
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..33
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            34..222
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    220..222
                     /gene="Hp1bp3"
                     /note="upstream in-frame stop codon"
     exon            223..322
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1788
                     /gene="Hp1bp3"
                     /note="isoform b is encoded by transcript variant 6"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform b"
                     /protein_id="NP_001423785.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPE
                     NETPPAPSREAEQPKGEPESGEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLS
                     ASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLER
                     RGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVK
                     LEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQ
                     ITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPG
                     TNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSE
                     DEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRG
                     KVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKK
                     KSFKTKK"
     misc_feature    589..843
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    589..843
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(610..612,646..648,742..744,784..786)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(610..612,646..648,742..744,784..786)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    727..762
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    727..762
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    916..1098
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    916..1098
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1144..1347
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1144..1347
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1531..>1755
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1531..>1755
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            323..476
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..636
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..780
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..858
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1010
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1101
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1261
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1373
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1490
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..3174
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgtgg ccgccattac ggagttccca gtggttgact cttcaccaca ctgaagccat
       61 taggaaaccc ctgtgattaa cagcagaggc ttcagagtct caccagtatt caggcctaga
      121 ctttatttta aatggcaact gatatgtctc aaggtgaact catccatcct aaggcactcc
      181 cacttatagt aggagctcag ctgatccacg cggacaagtt agaaagcaga cgatagcacc
      241 atgcctatcc gtcgggctgt gaattctact cgggaaactc cgcccaaaag caaacttgct
      301 gaaggggaag aagaaaaacc agaaccagat gggagttcag aggagtctat ctctacggta
      361 gaagaaccag agaatgagac tccacctgct ccatccaggg aggcagagca gcccaagggg
      421 gagcctgaga gtggagagaa ggaagagagc aagtctgctg aggaaaccaa gaaagaagag
      481 aaggatcagt ctaaagaaaa ggagaagaaa gtgaagaaaa ccatccctgc ctgggccact
      541 ctgtctgcca gccagctagc cagggcccag aaacaaaccc caatggcttc ctccccacgg
      601 ccaaagatgg atgcaatctt aactgaggcc attaaggcat gcttccagaa gagcggtgcc
      661 tccgtggttg ctatccggaa gtacatcatt cataagtacc cttctctgga tctggagaga
      721 aggggctatc tcctcaagca agcactgaaa agagagttaa acagaggagt catcaaacag
      781 gtaaaaggaa aaggtgcatc tggcagtttt gtcgtggtcc agaaatcaaa aacacctcag
      841 aaatccaaaa acagaaagaa gggctctgca gtggatccag aaccacaagt aaaactggaa
      901 gatgttctcc cattggcttt tacccgactc tgtgaaccta aggaagcctc ctacagtctc
      961 atcaggaaat acgtgtctca gtattaccct aagcttcgag tggacatcag gccccagttg
     1021 ttgaagaatg ctctgcagag agcagtggag agaggccagt tagagcagat aactggcaag
     1081 ggtgcttcgg ggacattcca gctgaagaaa tccggggaga aacccctgct tggtggaagc
     1141 ctgatggaat atgcaatctt gtctgccatt gctgccatga atgaacctaa gacctgctcc
     1201 accactgctc tgaagaagta tgtcctggag aaccacccag ggaccaattc taactaccaa
     1261 atgcatttgc tgaaaaaaac tctgcagaaa tgtgagaaga atgggtggct ggagcagatc
     1321 tctgggaagg ggttcagcgg caccttccag ctgtgcttcc cctattaccc cagcccagga
     1381 gttctgtttc caaagaaagt gtcagatggc tctgaggatg aggatgagga ggaggatgaa
     1441 gaggagtcat cagaggactc tgaggatgaa gagccgccac ccaagaggag cttacagaag
     1501 aaaacaccag ccaagcccca agggaagacg gcctccatga agcagagagg ggctaagcct
     1561 gcgcgtaaag tccctgctgc ccagagaggg aaggtgaggc cgctgcctaa gaaagctccg
     1621 cccaaggcta agacccctgc caggaaaggc agacccgcac cctcagccgt caagaagcct
     1681 agcgggagca cctccaaaaa gcctgtagcc aatgcacgaa aggaagcgaa actgcccggt
     1741 aagggcaaat ctgccatgaa gaagaagtct ttcaagacaa aaaagtaaat tttataggaa
     1801 aaagggtatc atgattgaat tcagaatctt attttataag gtcagtgtgc atttgtttta
     1861 gttataatgc ttttaaattt tacatttttc ttcccatacg aacactgtgg gaaggaatgt
     1921 aaacaaacca gtgtagacat ttgttggctt aggtgctgtt ctcagtgcct gcttcttcat
     1981 cattttaatt tctgccgtaa tcctggactt ggctgaactg tgtaactacc ctgctccctt
     2041 tgttcatctt aacccaaccc tcattctctt ctttttgtga tccaatttgg ggttttcttt
     2101 tcctcctcga agttaatcca aacagttgca aagatgcatt tgtagtgagt acctccaggt
     2161 ctggtgctga agccagacgg agcgggagca ctacagggac agcattgctt cctgcctggg
     2221 gacttgctga ttgaccctgg ctgtgaaatc actccactaa cctttctcca gcgtgggcca
     2281 gggacattat aactttggaa agaagcccca gtctgccatc catagattct gaagatctct
     2341 tctcctttgc tgtctgccca gttgccaagc acgccctgct gcccagagcg ttgttccctt
     2401 aacagcaagc gcacgtctgc gccacctgct ttctgactga aggggaagta caggaatatg
     2461 tggaatctga ttgcttatta ccaaaaatga cagaatattc ttgatcaaag gcctagatat
     2521 atttttaata tttggggcat gagcttcccc tgtttgagag ttcccattac tgaggtagaa
     2581 atgttaattt gctaaacata atttgctaaa atgaccagtt ttcagattca cctgtgcgtg
     2641 tgcccccact cgcaccccac cccattctct ccatagaacg tttgctgtca gctcggcggt
     2701 ctccatttcg aggtgtttat cagaagcgag gaggggagca aatgaagccg tgctgcccag
     2761 ccctcctcgt cttgtatttg tttaggttgt gaggttgtgt aaatagtagc ttcctacttg
     2821 agaactacag ctcctgctta tcattgatcc tttcctgtgg cacttaatat tttaattgtc
     2881 ttaagctttt gatgtacatc ctctggcccc ttacacgctg ccagaggaga aggtgtttga
     2941 gattcattcc acttgaagtg tctttcctgg gctccccaca gctgcagatg gctgggaagt
     3001 ggacttgagg aatgggctcg aattggtggt tcatgcctgt gaggacccat catgagtcat
     3061 cgggatttgt gttgcatgga aggcaatctt tcctgttgta aatcttcctt ttttatgtac
     3121 atatattttg aaaatatgaa taaacatgaa attttaaaag ctgctgaact acaa
//
LOCUS       NM_001108660             821 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 2, mRNA.
ACCESSION   NM_001108660 XM_001061271 XM_342823
VERSION     NM_001108660.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 821)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 821)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 821)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 821)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 821)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 821)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 821)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 821)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 821)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001108660.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2337140.1,
                                           SRR26360181.3322328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000005.1  61741422-61741766   c
            346-405             JAXUCZ010000005.1  61741152-61741211   c
            406-503             JAXUCZ010000005.1  61738859-61738956   c
            504-636             JAXUCZ010000005.1  61737621-61737753   c
            637-821             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..821
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..345
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             299..793
                     /gene="Ccl27"
                     /note="isoform a is encoded by transcript variant 2; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform a"
                     /protein_id="NP_001102130.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSPMPPTSQR
                     LSLEPPRLPLTGWHPWNKTKEKQEALPLPSSTSCCTQLYRQPLPTRLLRRIVRVELQE
                     ADGDCHLQAVVLHLTRRSVCVHPQNRSLARWLERHGKRLQGTLPSLNPVLQKKMCPSP
                     QKQK"
     misc_feature    524..706
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    524..706
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            346..405
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..503
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            504..636
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            637..821
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaatc tccattcagg gcctaaacgt cccagctata ctgccgctag acccctctcc
       61 ttggtgactc cacgttccgg tccctagata gccatcctcc taacgcttta acttgtagtg
      121 atttccatat catccatccc atcctgtccc gatgtgacca ttggcttccg ggagggccac
      181 ctgcctcagt gtacctgagt attcagactt gtcctgggaa tgatggaaaa gggaacttgc
      241 aactgggaat aagtgttcct atcatgctgc tccccaggaa ccgttcggag ctcgagacat
      301 gtcgcgattg aggagatacg aggtggcgct ggaagcggag gaggagatct actggggctg
      361 cttctacttt tttccttggc tgcgaatgtg gcgcagggag cggagtccga tgcctccaac
      421 aagccagaga ctaagtctgg aaccccccag gctcccgctg acaggctggc atccgtggaa
      481 caagactaag gagaagcaag aagccttgcc actgccctcc agcactagct gctgtactca
      541 gctctatagg caaccactcc caaccagact actgaggagg atcgtccgtg tggagctgca
      601 ggaggctgac ggggactgcc acctccaagc tgttgtgctt cacctgactc ggcgcagtgt
      661 ctgtgttcat ccccagaacc gtagcctggc tcggtggtta gaacgccatg ggaaaaggct
      721 ccaggggacc ctacccagtt taaatccggt actacaaaag aaaatgtgcc cgagccccca
      781 aaagcaaaag taataaagca acattagacg ataatctcca a
//
LOCUS       NM_001436857            3053 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 7, mRNA.
ACCESSION   NM_001436857
VERSION     NM_001436857.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2180327.1,
                                           SRR26360176.1831048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000005.1  155719134-155719237
            105-204             JAXUCZ010000005.1  155724942-155725041
            205-358             JAXUCZ010000005.1  155726205-155726358
            359-518             JAXUCZ010000005.1  155728962-155729121
            519-662             JAXUCZ010000005.1  155732660-155732803
            663-740             JAXUCZ010000005.1  155734814-155734891
            741-889             JAXUCZ010000005.1  155735362-155735510
            890-980             JAXUCZ010000005.1  155738870-155738960
            981-1140            JAXUCZ010000005.1  155740995-155741154
            1141-1252           JAXUCZ010000005.1  155742543-155742654
            1253-1369           JAXUCZ010000005.1  155743955-155744071
            1370-3053           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3053
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..104
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..204
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1667
                     /gene="Hp1bp3"
                     /note="isoform c is encoded by transcript variant 7"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform c"
                     /protein_id="NP_001423786.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPE
                     NETPPAPSREAEQPKGEPESGEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLS
                     ASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLER
                     RGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNRKGSAVDPEPQVKL
                     EDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQI
                     TGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGT
                     NSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSED
                     EDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRGK
                     VRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKKK
                     SFKTKK"
     misc_feature    471..725
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    471..725
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(492..494,528..530,624..626,666..668)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(492..494,528..530,624..626,666..668)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    609..644
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    609..644
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    795..977
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    795..977
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1023..1226
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1023..1226
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1410..>1634
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1410..>1634
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            205..358
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..518
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            519..662
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..740
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..889
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..980
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1140
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1252
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1369
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..3053
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcggt gcccggcctg gaggacagcg gtgtcggagt cagcgatcgg tggtccgcag
       61 caacgctgag gggccgtacg ggacgcaggc gccggagctc agagaaagca gacgatagca
      121 ccatgcctat ccgtcgggct gtgaattcta ctcgggaaac tccgcccaaa agcaaacttg
      181 ctgaagggga agaagaaaaa ccagaaccag atgggagttc agaggagtct atctctacgg
      241 tagaagaacc agagaatgag actccacctg ctccatccag ggaggcagag cagcccaagg
      301 gggagcctga gagtggagag aaggaagaga gcaagtctgc tgaggaaacc aagaaagaag
      361 agaaggatca gtctaaagaa aaggagaaga aagtgaagaa aaccatccct gcctgggcca
      421 ctctgtctgc cagccagcta gccagggccc agaaacaaac cccaatggct tcctccccac
      481 ggccaaagat ggatgcaatc ttaactgagg ccattaaggc atgcttccag aagagcggtg
      541 cctccgtggt tgctatccgg aagtacatca ttcataagta cccttctctg gatctggaga
      601 gaaggggcta tctcctcaag caagcactga aaagagagtt aaacagagga gtcatcaaac
      661 aggtaaaagg aaaaggtgca tctggcagtt ttgtcgtggt ccagaaatca aaaacacctc
      721 agaaatccaa aaacagaaag ggctctgcag tggatccaga accacaagta aaactggaag
      781 atgttctccc attggctttt acccgactct gtgaacctaa ggaagcctcc tacagtctca
      841 tcaggaaata cgtgtctcag tattacccta agcttcgagt ggacatcagg ccccagttgt
      901 tgaagaatgc tctgcagaga gcagtggaga gaggccagtt agagcagata actggcaagg
      961 gtgcttcggg gacattccag ctgaagaaat ccggggagaa acccctgctt ggtggaagcc
     1021 tgatggaata tgcaatcttg tctgccattg ctgccatgaa tgaacctaag acctgctcca
     1081 ccactgctct gaagaagtat gtcctggaga accacccagg gaccaattct aactaccaaa
     1141 tgcatttgct gaaaaaaact ctgcagaaat gtgagaagaa tgggtggctg gagcagatct
     1201 ctgggaaggg gttcagcggc accttccagc tgtgcttccc ctattacccc agcccaggag
     1261 ttctgtttcc aaagaaagtg tcagatggct ctgaggatga ggatgaggag gaggatgaag
     1321 aggagtcatc agaggactct gaggatgaag agccgccacc caagaggagc ttacagaaga
     1381 aaacaccagc caagccccaa gggaagacgg cctccatgaa gcagagaggg gctaagcctg
     1441 cgcgtaaagt ccctgctgcc cagagaggga aggtgaggcc gctgcctaag aaagctccgc
     1501 ccaaggctaa gacccctgcc aggaaaggca gacccgcacc ctcagccgtc aagaagccta
     1561 gcgggagcac ctccaaaaag cctgtagcca atgcacgaaa ggaagcgaaa ctgcccggta
     1621 agggcaaatc tgccatgaag aagaagtctt tcaagacaaa aaagtaaatt ttataggaaa
     1681 aagggtatca tgattgaatt cagaatctta ttttataagg tcagtgtgca tttgttttag
     1741 ttataatgct tttaaatttt acatttttct tcccatacga acactgtggg aaggaatgta
     1801 aacaaaccag tgtagacatt tgttggctta ggtgctgttc tcagtgcctg cttcttcatc
     1861 attttaattt ctgccgtaat cctggacttg gctgaactgt gtaactaccc tgctcccttt
     1921 gttcatctta acccaaccct cattctcttc tttttgtgat ccaatttggg gttttctttt
     1981 cctcctcgaa gttaatccaa acagttgcaa agatgcattt gtagtgagta cctccaggtc
     2041 tggtgctgaa gccagacgga gcgggagcac tacagggaca gcattgcttc ctgcctgggg
     2101 acttgctgat tgaccctggc tgtgaaatca ctccactaac ctttctccag cgtgggccag
     2161 ggacattata actttggaaa gaagccccag tctgccatcc atagattctg aagatctctt
     2221 ctcctttgct gtctgcccag ttgccaagca cgccctgctg cccagagcgt tgttccctta
     2281 acagcaagcg cacgtctgcg ccacctgctt tctgactgaa ggggaagtac aggaatatgt
     2341 ggaatctgat tgcttattac caaaaatgac agaatattct tgatcaaagg cctagatata
     2401 tttttaatat ttggggcatg agcttcccct gtttgagagt tcccattact gaggtagaaa
     2461 tgttaatttg ctaaacataa tttgctaaaa tgaccagttt tcagattcac ctgtgcgtgt
     2521 gcccccactc gcaccccacc ccattctctc catagaacgt ttgctgtcag ctcggcggtc
     2581 tccatttcga ggtgtttatc agaagcgagg aggggagcaa atgaagccgt gctgcccagc
     2641 cctcctcgtc ttgtatttgt ttaggttgtg aggttgtgta aatagtagct tcctacttga
     2701 gaactacagc tcctgcttat cattgatcct ttcctgtggc acttaatatt ttaattgtct
     2761 taagcttttg atgtacatcc tctggcccct tacacgctgc cagaggagaa ggtgtttgag
     2821 attcattcca cttgaagtgt ctttcctggg ctccccacag ctgcagatgg ctgggaagtg
     2881 gacttgagga atgggctcga attggtggtt catgcctgtg aggacccatc atgagtcatc
     2941 gggatttgtg ttgcatggaa ggcaatcttt cctgttgtaa atcttccttt tttatgtaca
     3001 tatattttga aaatatgaat aaacatgaaa ttttaaaagc tgctgaacta caa
//
LOCUS       NM_001436851            9073 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 2, mRNA.
ACCESSION   NM_001436851 XM_006253223
VERSION     NM_001436851.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9073)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006253223.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3021924.1,
                                           SRR26360172.2759995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840122 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000016.1  62495328-62495479   c
            153-377             JAXUCZ010000016.1  62494663-62494887   c
            378-566             JAXUCZ010000016.1  62470460-62470648   c
            567-721             JAXUCZ010000016.1  62460835-62460989   c
            722-895             JAXUCZ010000016.1  62453208-62453381   c
            896-9073            JAXUCZ010000016.1  62439625-62447802   c
FEATURES             Location/Qualifiers
     source          1..9073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..9073
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..152
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            153..377
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            378..566
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    559..561
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="upstream in-frame stop codon"
     exon            567..721
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..1908
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /codon_start=1
                     /product="probable tRNA methyltransferase 9B"
                     /protein_id="NP_001423780.1"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
                     /translation="MDPEAVQLEKQHVHKVYESTAPYFSDLQNKAWPRVRQFLQDQKP
                     GSLIADIGCGTGKYLKVNSQVHTLGCDYCGPLVEIARNRGCEVMVCDNLNLPFRDQGF
                     DAIISIGVIHHFSTKQRRIRAIKEMARVLAPGGQLMIYVWAMEQKNRHFEKQDVLVPW
                     NRALCSRLLSESHQSWGHSCEHPTSQGYQGPGSACSCAVCFKGRCDSKRSHSMDYGPA
                     VARTCCEAISKEGQQENGLYSNFGKSFRSWFFSRSLDESTLRKQIERVRPMKIEGWAN
                     STVSHQPSRYPSVDLHAQEPFSTKRPNLDEVFVDASSQRHVGCLGVPSTSDNFIGHKG
                     GESRRKEGGNFLDTTDTGNSVAARNGGDRSARKILRRVSAFDSTDSTSEDPSFVEGQQ
                     DGPDSKAFMRYYHVFREGELSSLLQECVSELQVLSSGNDHGNWCIIAEKKRSWD"
     misc_feature    655..996
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     misc_feature    655..996
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     exon            722..895
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            896..9073
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggccgaccc atggaagttg catcctggac
      181 agtccgggct gcgacgctga agagcaccga gccagtgctc ggccgagcct cccgcccgga
      241 tcccgggcaa agaccgccca aaacctgctg ttgaccttcg tctgcactgc tcaatggtga
      301 cccgagtctt cgctgtccta gttgcagcca tttggcatcc ccaagactgc cagagcaccc
      361 gggatctgca aacctggggc ttggattctc ttcagagact catactgagt ggtggatctt
      421 gtgaagggct cactaactca attcctgctc ctttcatgtg tgttatatac tgagagccct
      481 gagaaggaac tgttcctccc tgaggaagga aactgccgtg atttaccaaa accagaaata
      541 atccacatga tcacaaaatg agtcaggatg gatcccgaag ccgtgcagct ggagaagcag
      601 cacgtgcaca aggtctatga gagcaccgcc ccctacttca gtgaccttca aaacaaagct
      661 tggccccgcg tccgccagtt cctgcaggac cagaagccag gcagcctcat cgctgacatt
      721 ggttgtggaa ctggaaagta tcttaaagtg aatagccaag tacatactct gggctgtgac
      781 tactgtggcc ctctggtaga gattgcccgg aatagagggt gtgaagtcat ggtatgtgac
      841 aaccttaatc tcccctttag ggaccagggc ttcgatgcta tcatctccat aggagtcata
      901 catcatttct ctacaaaaca gagaagaatc agagcaataa aggaaatggc cagggtctta
      961 gctcccggag gccagctgat gatttacgtc tgggcaatgg aacagaagaa ccgacacttt
     1021 gagaaacagg atgtgcttgt gccatggaac agggcactct gttcccggct gctgtcagaa
     1081 tcccaccagt cgtgggggca ttcgtgtgag catcccacga gccaaggcta ccagggccct
     1141 ggctccgcgt gcagctgtgc agtgtgtttt aagggcagat gtgattccaa gcggtcgcac
     1201 agcatggact acgggcctgc ggtggccaga acctgctgcg aagctatttc gaaggaagga
     1261 cagcaagaga atggattata tagcaatttt ggaaaatcct ttcgctcctg gtttttttcc
     1321 aggtctttgg atgaatcaac cctgaggaag caaattgaaa gggtcaggcc gatgaaaatc
     1381 gagggctggg ccaacagcac cgtgtcccac cagccttccc gataccccag cgtagacttg
     1441 catgcccagg agccgttttc aacaaaaaga ccgaacttag atgaggtgtt cgtagacgca
     1501 tcttctcaaa gacacgtggg ctgcctggga gtacccagca cttcagacaa cttcattgga
     1561 cacaagggag gagagagtag gaggaaggag gggggcaatt ttctggacac cactgatacc
     1621 gggaacagtg tggctgcaag aaatggcggt gatcgttctg ccagaaaaat attaaggagg
     1681 gtttctgcat tcgactccac ggactccacc tcagaagacc caagctttgt ggaagggcaa
     1741 caggatggcc cagattccaa agccttcatg cgttactacc acgtgttccg ggaaggtgag
     1801 ctgtccagcc tgctgcagga gtgtgtgtct gagctgcagg ttctgagctc cggcaatgac
     1861 catggtaact ggtgcatcat cgcagagaaa aagaggagct gggattaact acatcgctca
     1921 aggcagaggc tacagcccat catctgctca atggggctga tgtggacacc agaatcggca
     1981 ccctagttca ttgctttcaa atccaggtat gagtcggacc gtgagcactg tgccctcatc
     2041 ctccgaactg ttgagtaagc atgaaggctg gcatgtcctg cctctgctgc gggatctgcc
     2101 tgctgaagtt tcaatcaaag gatccgagga agcagtagaa agtaaactta agtacagact
     2161 tgatcttatt cctcccagag atgaaattat tacgatacgt gtacgtcaag tgtcagtatt
     2221 atcttttggt ttttaaataa tcccctgtta aatatacctt ttaaaagtag taatttttaa
     2281 aaataaatta tgttggttct caggtagtta cttagatccc tgtggaaggt aacagagaca
     2341 cctgtgctgt tgctgggcat gtgtttaagg ttcgctgtgg tggtatctcg tttccggact
     2401 tcgttgctaa ctacatcaac ccttccagta tagcccagac cctctaaatt acatgcaaac
     2461 gcccttaggg atgatcgatg ttactaatac tgtcttcagc attgctctga ggcttttaca
     2521 aggcgctatt agcagagggt tggtgttaaa gcagacagtt tgcatgcggc ggaatcagca
     2581 aacatccatg gcaccattga cagaagaaaa agtaaacaaa ggattgttag cgtgcagagt
     2641 gctttacagg ggtagcagat ggtatgtccc ctggtcacat tttccccaaa ggcattagga
     2701 gcataaatat ctaactgagg ttgtcccaaa gttatccaga gttttcaact aggaagtgca
     2761 tatctgagtt agctaagagt ctaattggag ccgttttact ttggctgtga ggacagatct
     2821 ggaaatcgtc atgtatttag tggacacatt actgggattc gctgctgcat gccatggcat
     2881 ttattccctt gaaggtgacc acattagatc attgtatcag tgacctggac ggaatcaaag
     2941 cttggtcaca agttgaattt ctggtattct agagtgcaat gattagactg ggtatggtac
     3001 aaatcaatac tcttttattt ttaaagactt aatcatgagt ctgattaatt ctatgttgtg
     3061 gatcccaata acaattatga cagaattcaa gactgaactc aggagaaaca aaaataagtt
     3121 ggccaaggaa tatggttcca gataattcgt taacaagcag gaaatcaaat agtcattgta
     3181 ctttctggac cgatataatg atggagattg gattaaaatc caatcttcac tttctttttt
     3241 tctcccacta caaagttaac aaaaattgca atggatcata tttatttggt gtttaccctc
     3301 ttcagagatt ttgctggact gtatgaaaat gaagctactt ttgaaaaaca caactcaaaa
     3361 ggtgctttga aaatgcaaag tatatcttgt aaactttaga atgaatcaga taattcctga
     3421 ggttctttca agtccaagtt ccgtctcttc aaccctgctg tggaagtggc atgtgtgtct
     3481 tgtactttcc agcgtacact ttgtacaggg aggcatgaaa ataggcatag gggtaaagca
     3541 tagattaaaa tttactgtgc cttccacttc ttcaaatgaa gatattaaac tccatgtacg
     3601 gtggcttcct gggagaagcg gtgactctga actagtcagc agtaatgacc tctttattat
     3661 ggtttcccgc ttctctgagg tctgtgtcac tttgacttgg ctttcgctgc tggatgtcta
     3721 agcctgacat caccctggtt ggaatgtgct acctaaaggt cattctatgg aactcagttc
     3781 atcaggctgt gacaggatgg tttaccagct gatatgtctg aacaagctca caaaataaac
     3841 acacacccca tcttgtatta aaaagccttc ggaatggtta ttgggataga gagagatttt
     3901 tcctacaatg atagagctgt gagcgctaat aacaccaacc ttgttaagtg caagaattcc
     3961 atgcatccag atgttttatt gtctatttag caaaatctgt ggctggtaag cttcctggga
     4021 tccttgtgca aaagcagtct tccattcagt gtttgccttt tgatgataaa aagccattga
     4081 gaactagtgt aaatatctta accgtttaaa aggttgttct cctttgggat tgtcctcaga
     4141 aggaaacaca agtcctaaat gtatataaat ggagacggtg tatgtccgtc ggccttaatc
     4201 agcttgtggg tggatctcac tgatctgtct aaagtgatgg aaaaaacctt ctccacgtta
     4261 agacaaaatg gtgtttttct aattccctcc tggcatccac acatgagtcc cactgtctga
     4321 cggagggaaa gttcagggaa gtcattagat aattgttaga ggttggacta gcagtacctc
     4381 cccggcttgt gtggggcact ttgtggaaac agacaagtga tttgggggga aaagtgattg
     4441 acttgaacga aagatgcaat caaagtaaca gtttcctggg aggcgagtga ttggcaagct
     4501 tctctggtta ttgggtttta gtgttcatgt gggggtgggg gggtgttctt tgttggcaga
     4561 gagacgaagt atgaccagag tgctgcagtg cttcaggctg gctatgcaca cacactggct
     4621 gccatgctga ttgatccttt cctctaacct tgctgtacgc catccccata ctgtctgtca
     4681 ctcattttgc ctacccctca tcctgattct ggaggccaaa gactcccatg tgctcaactg
     4741 accttcattt gagtcagcaa aaaaacaaaa aaacaaaaaa caaaacaaaa aaaaaaacaa
     4801 aaaacaaaac aaaaaaacaa aaaaaaactg aaggtgattc aggtgggaaa ggatccaaat
     4861 gtaaatcagg atttcaaaag tacttgacta ctattggcca tggaacaaat gaatgctggt
     4921 agatctttca aatacgtggg ctcccaggag aacaggaaat gggaccctag ttgtactcat
     4981 tatgtgagtg aatgccttag aaacaaggtg tgagggccta ctgggtggct tgctggttta
     5041 gagtgctgtc ctgcagatgg cctgaaagtg gctcctagca ccatgtcaga cagctcacaa
     5101 gtgcctcttc aggatgccga gggtacctgc actctcgtgt gcacagacct aagcatacat
     5161 gcacagacac agacacagac acacacacac acacacacac acacacacac acacatacac
     5221 agacacatgc acacacagac agacacagac acacacacag acacatacac agacacacac
     5281 acacacaggc acacacacag gcacacacac agacacacac acaggcacaa acacacagac
     5341 agacagacac acagacagac agacagacac acagacacac acacacacac acacacacac
     5401 acaccaaaaa taaatatttt ttaagaacag gctatgcatg cccagcctga atgaggaaac
     5461 tgaagtaact gttcactact tggttcttca gagcctgttg tgatggtgca gaaaaaagta
     5521 agccaagtct cacttttcct gaacagaaga agggatgggt aacaatagca gctgactaat
     5581 atttatcacg ttatgtgtgt aacccccaat agctgtctca aacaaatata atccccaatt
     5641 tgcagataag aaaggcagaa aaggaaaaag ataataatgc gctaagatat cagaatctac
     5701 acaagcagta aacatcaccc atttagtgaa aaacagctaa gattcagtcc tagactgtct
     5761 ggatccggtc taagttcata accacctgcc aggtcccaga ctctatgcca agtaagcaac
     5821 agagtgtgca aggttaagtg tgactgtccc ctgcacaaat gcattaagca ggttaggaaa
     5881 agactacacc tctctttccc cttcgtgctg tcttttcagt atttcacatg tacttgtctg
     5941 tgcatctgtc cctgaggagg tcggaagata gcttgcaaga gttagttcat tcctctaaga
     6001 tctatatgtc ccctgagccc tcttgccagc cctgttttgt ttctttgttt gttttataat
     6061 tctatttcta tttgactaga atttaaaaag ctcttgatca cagggcactc tgatcacttt
     6121 ctacaattcc caaaccctcc aaaaagcata gctctgtttt cctgttttaa tcaatgaaga
     6181 acttagggac taacacaggt attccttttt tttttttttt ttttgttcag aaccgtttgg
     6241 tgtctctaga tacaagtgat gaaagccagg acatatctgg ggtattgggt tatacacaat
     6301 atgaagactt aatgaccaaa aattcaagtg tcctgctgga acacattttg tttttgctgt
     6361 atgtctgtga tcacatgaca ttgttagttt tgtaaaacac aatattcaaa cccccttcct
     6421 ggggtggggg aagagaggat cacgatgcat ataattaaca tggagaatgc ctgtctgaca
     6481 cacttagatt tcatttaact gaggctaccc tgggccaatt gacacagcct ccagcacaag
     6541 tgctcagtaa acgtatttca gaaaaggatg tgtcctgtag ggacagatat gaagtcattc
     6601 ggaaggcatg caggccccta gtaaccaact caagttctgt ttcagactcg tttcctacaa
     6661 ttgcacctgt tttctgttct gcaatcagct attttaaaca atgatttcat taaaactaca
     6721 taatagcaag tcattatccc atcccttgaa gggatctaat atattcagac tagaaatgct
     6781 gttaattata aactttcctc aaagacagac gcaccagcag gctcattcca tcaatagaca
     6841 caggaatgct agcactcatc tggcaaaggg agccctggga aagtgagagg atcagaagcc
     6901 ccacttgata tttcaagtcc tctggtccca gccttgggtc agaaaccaga actctgtttt
     6961 gacaccatgg actccatccc caagtctcca gttatattca aaactggggt aagaacttaa
     7021 aaaaaaaaaa aagctcttag caaccaagaa ctgagatcaa agcacaaata gcattccaag
     7081 ggagggaaga ctggaaaccc aagagaatga tgaaacaaaa cgcaggctat gaagtgtaca
     7141 gtttttcatc ttgtttgaaa cagggtctca tgtatcctaa actggccctg aacttgctgt
     7201 gtacttgagg ataaccttaa cttctgatcc tcctggtttc tatgagacag gagatccagt
     7261 gcaaggcctg atgcataata ggcaggaact caacccattg agcctcatct ccagccccaa
     7321 gctgtgtaac gcattattca ccctgagtcc cacagtgtac cccagtagta gaagtgtttc
     7381 attggagtgt taccctactg tctgcccctc cactatgacg gttctccttc gatggattat
     7441 aaacagacaa tagatcactt catgttgcta cgtaatctgg ctaatccaat ggaccacttg
     7501 tgagaactga tatccgatca gatactcaac tggcaaatac acgctttgtc tcctttcgac
     7561 tagagctggg aaaaaaataa agcagactct agtataatta agtgttaatt caaccacatg
     7621 aaaacacctg attttctcct tagttatttg tcgaaggctc ctatctcatg ggggaaagtg
     7681 agtgccttag tttcggtttt attgctgtga ccatggcaac tcttgtaaat gtaaacattt
     7741 gatgagggct ggcttacagt ttcaaaggtc cattatcatc atagcaggaa gcatggcagc
     7801 aggcatggtg ctggaagagc caagagttct acatcttggt ctgcaggtag cagaaggaga
     7861 ctggcctcca caggcagtca ggaggaggct ctgattccac actggatgta gtttgagctt
     7921 ttatatgaga ccggaaagcc tgcccccaca gtgacacact tccttcaaca aggccacacc
     7981 tcctaatagt atccctccct gtgggccaag cattcaaaca catgaatcta tgtcagtcaa
     8041 acctattcca accagcacgg tgagtcatgg taattccttt atggcaagtg tagccagata
     8101 tcaaaagtcc ttagacgaag tatccacaaa tttgcattca tacaggagaa aaactatgaa
     8161 acacaagctt cctcttatgc actaatccta aaacttctcc ttagatggtg tatggtaaga
     8221 actcaaaatt ctcctgtttg tttatccagg acattggcaa tatttaagac ccacatgtaa
     8281 gatctaagac attctgaata tgtatgtgaa catgtcccat gttcttcaga tgctcttcaa
     8341 tatgtatgta tgtaatatat atgtgcatac gcatatttgt agactcccag tgtttgttgt
     8401 cattactgac caggaaaaga gttctcttgt gtgcttgcag aagacattaa attagcaatt
     8461 accataggaa cgcatctcat tgaattggcc tttattgttg cttcaggagc atttaagaag
     8521 actgctagat gctttcatgc cttccctggt gttgacatat gtatttgtgt caaaagtgtg
     8581 aagctttttt ccccttaaat atagttattt taatctcccc cccccagggg gaactagcaa
     8641 tagatctaga gcacaaattg atgtaagaca tcttgactct tacaataacc taaagatatt
     8701 tatttacgtg aaccaacagt ggccaggatc tttttgtaac agctatttaa aatagcataa
     8761 tttgtatgcc tgtgatatgt agttgattat ttatgtgttt gtgtattctt taataatagt
     8821 ctcaaacaaa caggattgga gttttcttcc tcccgaatgt gtcagggcag gtgctgttag
     8881 gctcgctcac atgatgcttg ttacacttca atgaaactca accagtctgt acttgaattc
     8941 tgttcccgtt gtctggaagc tgggttagcc gtctaatgat acagcatctt ttatgggttg
     9001 atagaaagga tattatctac tttttaaaag acatatttta agactaataa aagacgtagt
     9061 agaccacccc aaa
//
LOCUS       NM_001436865            4301 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus SH3 domain and tetratricopeptide repeats 1
            (Sh3tc1), mRNA.
ACCESSION   NM_001436865 XM_006251127
VERSION     NM_001436865.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4301)
  AUTHORS   Senderek,J., Bergmann,C., Stendel,C., Kirfel,J., Verpoorten,N., De
            Jonghe,P., Timmerman,V., Chrast,R., Verheijen,M.H., Lemke,G.,
            Battaloglu,E., Parman,Y., Erdem,S., Tan,E., Topaloglu,H., Hahn,A.,
            Muller-Felber,W., Rizzuto,N., Fabrizi,G.M., Stuhrmann,M.,
            Rudnik-Schoneborn,S., Zuchner,S., Michael Schroder,J., Buchheim,E.,
            Straub,V., Klepper,J., Huehne,K., Rautenstrauss,B., Buttner,R.,
            Nelis,E. and Zerres,K.
  TITLE     Mutations in a gene encoding a novel SH3/TPR domain protein cause
            autosomal recessive Charcot-Marie-Tooth type 4C neuropathy
  JOURNAL   Am J Hum Genet 73 (5), 1106-1119 (2003)
   PUBMED   14574644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006251127.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.54899.1,
                                           SRR26643297.43714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000014.1  79230383-79230461
            80-307              JAXUCZ010000014.1  79245678-79245905
            308-382             JAXUCZ010000014.1  79247962-79248036
            383-510             JAXUCZ010000014.1  79250383-79250510
            511-616             JAXUCZ010000014.1  79250842-79250947
            617-763             JAXUCZ010000014.1  79252155-79252301
            764-974             JAXUCZ010000014.1  79252901-79253111
            975-1051            JAXUCZ010000014.1  79254113-79254189
            1052-1247           JAXUCZ010000014.1  79254965-79255160
            1248-1381           JAXUCZ010000014.1  79258759-79258892
            1382-1423           JAXUCZ010000014.1  79260358-79260399
            1424-3103           JAXUCZ010000014.1  79263174-79264853
            3104-3284           JAXUCZ010000014.1  79268013-79268193
            3285-3435           JAXUCZ010000014.1  79269560-79269710
            3436-3558           JAXUCZ010000014.1  79270972-79271094
            3559-3709           JAXUCZ010000014.1  79271275-79271425
            3710-3906           JAXUCZ010000014.1  79272325-79272521
            3907-4301           JAXUCZ010000014.1  79274229-79274623
FEATURES             Location/Qualifiers
     source          1..4301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4301
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats 1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
     exon            1..79
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..307
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="Sh3tc1"
                     /note="upstream in-frame stop codon"
     CDS             127..4164
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats-containing
                     protein 1"
                     /codon_start=1
                     /product="SH3 domain and tetratricopeptide
                     repeat-containing protein 1"
                     /protein_id="NP_001423794.1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
                     /translation="MRSFREEEATSEDLSTMGQGPEEPPGGCSLEDKIQSISMGLPTS
                     QERTGPEEAEATTVRGDVAPPCGMVGQAAEPPSNQMAVYPTDLTLQLLAVRRKSGLRS
                     PSLQQTLRSRLRLLENDSREVARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTY
                     HALGFTHHCLENLLVDQTFWLLSPSEEEETAILIYVNKDALKQTHKSLLAQEGSFFVL
                     CPDHCVRRTKEPQGAGKGPQTLRRASGVTLGVPVVETVSSSPTPSMSSKAEAVEAEPE
                     PLTPFHQWTLRVPWDPIDESMSGPGTPDAQFMRFGLASAIADFQGSGPEEMSFSVGDV
                     IEIVGAQVPGLPWCLGQHMASGQVGFVRTGLVRMQGPASDLESSIFLSEEERSFFRSE
                     AHFSDEDARRLLCRTSGTDVCTTCSLDWLEEAEGEQLEQQEMSLPHLNPEPHESLHMV
                     KNVLEKCKACPDHPEDPVSWSLGAVSSRVSSPDLEEPPFCLDPDDDWTDPEPPDSLLQ
                     VLSAPGYRAQFRSLYDISLPCLSTALYSFDDEEELAERLAQARGVAKKVDLGMALARL
                     CLLLGRLCARKLKLSQARVYFEEALGALEGSFGDLSLVAAVYSSLATVYLKQKNGEKC
                     VQLAPKAAALLLGTPGHSCSTDAELLKYALRRVVCGLSPQAEARACFLLARHYTHLKQ
                     PEEALPYLERLLRLNRDVGTPQASWPEDCYLLLADIYGRKCLPHLALSCLKVSSLWTR
                     CSLAGSLRSVDLVLQNAPGPNSQRSTGHSLPSQIAHYLRQALASLPPGTGQTLRGPLY
                     ASLAQLYSYHQQYGQAIAFMSQAAEADTAAGVHPVVDRLVALAWLHLLCGKSLVAMDI
                     LKCVSDAAVANKDQECVMMNMVAMALKRMGRTRQAAEGYFRALHMAYSQGHLQSQAVV
                     LANFGALCLQAGARSLAQHYLREAVGLFSQLPSGVCGRDFTQVLLWLGQLCTRRTLPQ
                     QAKCYYEWAFLVAVETDHLESQLQAVQKLCHFYSKVMPNEVRCVIYHEFQLALARKTA
                     DKVLEGQLLEAISQLYLSLGTERAYKSALDYTKRSLGIFIDLQQKEKEARAWLQAGKI
                     YYILRQNELVDLYIQVAQNAALYTGDPKLGLELFEAAGDIFFNGTWEREKAVSFYRDR
                     ALPLAVTVGDQEVELRLCNKLVALLSALEAPQEGLEFAHEALALSITLGDRLNERVAY
                     HRLATLHHRLGHGELAEHFFLKALSLCTSPLEFDEETLYYVKVYLVLGDIIFYELKDP
                     FDAAGYYQLALAAAVDLGHKKAQLKIYTRLATIYHNFLMDREMSLFFYQKARTFASEL
                     NLRRTNLVPQHFCSRAPWLAPGYPS"
     misc_feature    1060..1224
                     /gene="Sh3tc1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    1060..1224
                     /gene="Sh3tc1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(1075..1077,1081..1083,1090..1092,1102..1104,
                     1162..1167,1210..1212,1216..1221)
                     /gene="Sh3tc1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212818"
     misc_feature    order(1075..1077,1081..1083,1090..1092,1102..1104,
                     1162..1167,1210..1212,1216..1221)
                     /gene="Sh3tc1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212818"
     misc_feature    1939..2091
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1939..2091
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1942..1944,1951..1956,1963..1968,1972..1974,
                     2128..2130,2137..2142,2149..2154,2158..2163,2254..2256,
                     2263..2268,2275..2280,2287..2289)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1942..1944,1951..1956,1963..1968,1972..1974,
                     2128..2130,2137..2142,2149..2154,2158..2163,2254..2256,
                     2263..2268,2275..2280,2287..2289)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    <2122..2826
                     /gene="Sh3tc1"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    <2122..2826
                     /gene="Sh3tc1"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    2122..2214
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2122..2214
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2227..2325
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2227..2325
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    <2449..3816
                     /gene="Sh3tc1"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3899"
                     /db_xref="CDD:443106"
     misc_feature    <2449..3816
                     /gene="Sh3tc1"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3899"
                     /db_xref="CDD:443106"
     misc_feature    order(3610..3612,3619..3624,3631..3636,3640..3642,
                     3712..3714,3739..3744,3751..3756,3760..3765,3862..3864,
                     3871..3876,3886..3891,3898..3900)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(3610..3612,3619..3624,3631..3636,3640..3642,
                     3712..3714,3739..3744,3751..3756,3760..3765,3862..3864,
                     3871..3876,3886..3891,3898..3900)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    3610..3693
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3610..3693
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3619..3825
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3619..3825
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3706..3816
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3706..3816
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3733..3954
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3733..3954
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3859..3948
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3859..3948
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            308..382
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..510
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..616
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..763
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..974
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1051
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1247
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1381
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1423
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..3103
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3284
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3435
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3558
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3709
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3906
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4301
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttacccag tgaaggtaaa ggaggcccgg agggccccta cccacctttc tccttagcag
       61 cagctgctct actggcaaga aggccagcaa catgcccagc tcttggcctt gaggccactg
      121 tgagtcatga ggagcttcag ggaggaggag gcgacttctg aggatctgtc caccatgggg
      181 cagggccctg aggagcctcc aggaggctgt agcctggaag acaagatcca gagtatatcc
      241 atgggcttac ctactagtca ggagagaaca gggcctgagg aggctgaggc aacaacagtc
      301 agaggtgacg ttgctcctcc ctgtggcatg gttgggcaag ctgctgaacc cccttccaat
      361 caaatggcag tgtatccgac agacctcacc ctgcaattgt tggctgtgag gcggaagagt
      421 ggactgcgga gccccagcct acagcagacc ctgagaagcc gactccgcct gctggagaat
      481 gacagccggg aagtggcccg agtacttgga gaactgtcag ccaggctgct gtccatccac
      541 agtgaccagg accggatcgt ggtgacgttt aagacttttg aagaaatctg gaagttttcc
      601 acctatcatg ctcttggctt cacacatcac tgcctggaga acctgctggt ggaccagacc
      661 ttctggctgc tttcccccag tgaggaggag gagactgcca tcctcatata tgtaaacaag
      721 gatgccttga agcagacaca caagagcctt ctcgcacaag aagggtcctt cttcgttctg
      781 tgtcccgacc actgtgtgag gaggacaaag gaaccccaag gtgcagggaa gggcccccag
      841 accctcagac gggcttccgg ggtcactctg ggagtaccag ttgtggaaac agtctcctca
      901 tcccccacac ccagcatgtc ctccaaagca gaagcagtag aggctgagcc agagcccttg
      961 actccatttc accagtggac tctcagggtc ccatgggatc ccatcgatga atccatgagt
     1021 ggacctggga cgcctgatgc ccagttcatg aggtttggcc tggcctctgc aatagctgac
     1081 ttccagggct caggcccgga agagatgtcc ttcagcgttg gtgatgtcat cgagatcgtc
     1141 ggtgcccagg tgcctggcct gccctggtgt ttgggccagc acatggcctc tggccaggtg
     1201 ggctttgtga ggactggcct tgtccgcatg cagggcccgg catctgacct ggaaagttca
     1261 attttcctca gcgaggaaga aaggtcattc ttcagaagtg aggctcactt ctcagacgag
     1321 gatgcccggc ggctcctgtg caggacatct ggcacagatg tgtgtaccac atgcagcctg
     1381 gactggttag aagaagctga gggagaacag ctggagcaac aagaaatgtc tctgcctcac
     1441 ctgaacccag agccacatga gagtctgcac atggtaaaga acgttttaga gaagtgcaag
     1501 gcctgccctg accaccctga agaccctgta tcctggagcc ttggagcggt gtccagcaga
     1561 gtgagttcac cggaccttga ggagcccccc ttctgcctgg atcctgacga tgactggaca
     1621 gaccctgagc ctccggactc actgctgcag gtcctgagtg cccctggtta tagggcccag
     1681 ttccggagcc tgtatgatat ctcacttccc tgcctgagca ccgcactcta tagctttgat
     1741 gatgaagaag agttggctga acgcttggca caggcccgag gagttgccaa gaaagtcgat
     1801 ttgggcatgg ccctggcaag gctctgcctc ctgctggggc ggctgtgtgc ccgaaagctc
     1861 aaactatccc aggcccgggt gtactttgaa gaggccctgg gggctctgga gggaagtttt
     1921 ggggacctct ccctggtggc ggccgtgtat agcagcttgg ctactgtgta cctgaagcag
     1981 aagaacgggg agaagtgtgt gcagctggca cccaaagccg cagcgctgct cctgggaacg
     2041 cccggccact cctgcagcac agatgccgag ctcctgaagt acgcactgcg cagggtcgtc
     2101 tgtggcctca gcccacaggc cgaggcccgg gcctgcttcc tgctggcccg gcactacacc
     2161 cacctcaaac agcctgagga ggcactgcca tacttggaga gactgcttcg cctcaacagg
     2221 gatgtgggga ccccgcaggc ctcgtggcct gaagactgtt acctgcttct ggcggacatc
     2281 tatggccgga agtgcctgcc gcacctggca ttgagctgcc tcaaggtgtc ctcactgtgg
     2341 acaagatgct ctctggctgg ctccttgagg agtgtggacc tggtactcca gaatgctcct
     2401 gggccaaaca gccaaaggag cacaggtcat agccttccct cccagattgc tcactacctc
     2461 agacaggcat tggcctctct gcctcccggc acgggacaga cactgcgagg gccactctat
     2521 gccagcctgg ctcaattgta cagttaccac cagcagtacg gccaggccat agccttcatg
     2581 tctcaggctg cagaagctga cactgcagct ggggtccacc ctgtcgtgga ccgcttggtg
     2641 gcgctcgcct ggctgcacct gctttgtggg aaaagcttag tagccatgga catcctgaag
     2701 tgcgtctcag acgcggccgt ggccaataag gaccaggaat gtgttatgat gaacatggtg
     2761 gccatggccc tgaagaggat gggcaggacc cggcaggctg ctgaaggcta cttccgagct
     2821 ctgcacatgg cctacagcca gggccacctg cagagccagg cagtggtcct agctaacttt
     2881 ggggccctgt gcctgcaagc tggcgcacgc agcttggccc agcactacct gcgggaggcc
     2941 gtggggctct tctcccagct gcccagtggc gtgtgtggcc gtgacttcac ccaggtgctc
     3001 ctgtggttgg gccaactgtg tacgcgccgg accctccccc agcaggccaa gtgctactat
     3061 gagtgggcct ttctggtggc tgtggagacg gaccatctgg agagtcagtt acaggcggtg
     3121 caaaagctgt gccacttcta cagtaaggtc atgcccaacg aggtgcgatg tgtcatctac
     3181 catgagttcc aactggctct ggcacgcaag accgctgaca aggtgctgga ggggcagctc
     3241 ctggaggcca tcagtcagct ctacctgtcg ctgggcactg agcgggccta caagtcggct
     3301 ctggattaca ctaaacggag cctggggatt ttcatcgacc tgcagcagaa ggagaaggag
     3361 gcacgcgcct ggctgcaggc agggaagatc tactatatcc tccgtcagaa tgagctggtg
     3421 gacttgtaca tccaggtggc acagaatgca gccctgtata ccggggaccc taagctgggg
     3481 ctggaactgt ttgaggcagc tggggacatc ttcttcaatg ggacctggga gcgggagaaa
     3541 gctgtgtcct tctaccggga ccgggcactg cccctggctg tgactgtagg agaccaagaa
     3601 gtggagctgc gcctgtgcaa caagctggtg gccctgctgt ctgcactgga ggcaccccag
     3661 gagggcctag agttcgccca tgaggcccta gcactcagca tcaccctagg tgaccggctg
     3721 aatgagcgag tggcctacca caggctagcc accctgcacc accggctggg ccacggggaa
     3781 ctggccgagc acttcttcct gaaggctctg tcgctctgca cctcgcccct ggaatttgat
     3841 gaggagaccc tgtactatgt gaaggtctac ctggtactgg gtgacatcat cttctatgag
     3901 ctgaaggacc ccttcgatgc agctgggtat taccagctgg ctctggcagc agccgtggac
     3961 ctgggccaca agaaggctca gttgaagatc tatacacgcc tggctaccat ctaccacaac
     4021 ttcctcatgg accgagaaat gtccctcttc ttctaccaaa aagcaaggac ctttgcctca
     4081 gaactgaatc tccgcaggac caacctggta ccccagcact tctgtagccg ggcaccctgg
     4141 ttggcccctg gctacccatc ctgacaacct gagaaggggc acgtacaacg ggactcttcc
     4201 tcttcttggg gtatgggcaa cctattgtta ttattattat tcttttgctg agggttgggg
     4261 gtaactgaag gaccaaacag tagtaaatat ttttcagcaa c
//
LOCUS       NM_001007092            4414 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus calsyntenin 1 (Clstn1), transcript variant 4,
            mRNA.
ACCESSION   NM_001007092 XM_001075647 XM_243040
VERSION     NM_001007092.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4414)
  AUTHORS   Zhou,F., Hu,R., Wang,Y., Wu,X., Chen,X., Xi,Z. and Zeng,K.
  TITLE     Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models
  JOURNAL   Synapse 78 (5), e22307 (2024)
   PUBMED   39171546
  REMARK    GeneRIF: Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models.
REFERENCE   2  (bases 1 to 4414)
  AUTHORS   Ster,J., Steuble,M., Orlando,C., Diep,T.M., Akhmedov,A.,
            Raineteau,O., Pernet,V., Sonderegger,P. and Gerber,U.
  TITLE     Calsyntenin-1 regulates targeting of dendritic NMDA receptors and
            dendritic spine maturation in CA1 hippocampal pyramidal cells
            during postnatal development
  JOURNAL   J Neurosci 34 (26), 8716-8727 (2014)
   PUBMED   24966372
REFERENCE   3  (bases 1 to 4414)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   4  (bases 1 to 4414)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4414)
  AUTHORS   Vagnoni,A., Perkinton,M.S., Gray,E.H., Francis,P.T., Noble,W. and
            Miller,C.C.
  TITLE     Calsyntenin-1 mediates axonal transport of the amyloid precursor
            protein and regulates Abeta production
  JOURNAL   Hum Mol Genet 21 (13), 2845-2854 (2012)
   PUBMED   22434822
  REMARK    GeneRIF: findings show that amyloid precursor protein (APP) and
            calsyntenin-1 are co-transported through axons, that loss of
            calsyntenin-1 disrupts axonal transport of APP and that
            calsyntenin-1 loss also leads to altered APP processing and
            increased production of Abeta
REFERENCE   6  (bases 1 to 4414)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4414)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
  REMARK    GeneRIF: Calsyntenin-1 links a certain type of vesicular and
            tubulovesicular organelles to the Kinesin-1 motor.
REFERENCE   8  (bases 1 to 4414)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   9  (bases 1 to 4414)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4414)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001007092.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY569014.1, SRR26643429.21974.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000005.1  165314338-165314634
            298-420             JAXUCZ010000005.1  165347091-165347213
            421-616             JAXUCZ010000005.1  165357948-165358143
            617-825             JAXUCZ010000005.1  165359104-165359312
            826-975             JAXUCZ010000005.1  165361662-165361811
            976-1161            JAXUCZ010000005.1  165362057-165362242
            1162-1410           JAXUCZ010000005.1  165364336-165364584
            1411-1532           JAXUCZ010000005.1  165364894-165365015
            1533-1695           JAXUCZ010000005.1  165367642-165367804
            1696-1853           JAXUCZ010000005.1  165372011-165372168
            1854-2002           JAXUCZ010000005.1  165372364-165372512
            2003-2229           JAXUCZ010000005.1  165372762-165372988
            2230-2400           JAXUCZ010000005.1  165373487-165373657
            2401-2546           JAXUCZ010000005.1  165373961-165374106
            2547-2682           JAXUCZ010000005.1  165375061-165375196
            2683-2867           JAXUCZ010000005.1  165375492-165375676
            2868-4414           JAXUCZ010000005.1  165376081-165377627
FEATURES             Location/Qualifiers
     source          1..4414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4414
                     /gene="Clstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
     exon            1..297
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3065
                     /gene="Clstn1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; alc-alpha; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 4 precursor"
                     /protein_id="NP_001007093.1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
                     /translation="MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGIIRS
                     KEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYK
                     AAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYG
                     KEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPS
                     IHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSS
                     FNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKE
                     TILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHH
                     FVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQGGDLHMTQFFRG
                     NLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQAVLTLEGENV
                     GELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEP
                     KISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAEDPTVQESLVSE
                     EIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVFTGVETMASYE
                     EVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAA
                     QPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAA
                     HQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEE
                     DITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY"
     sig_peptide     207..290
                     /gene="Clstn1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     291..3062
                     /gene="Clstn1"
                     /product="Calsyntenin-1. /id=PRO_0000323601"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1)"
     mat_peptide     291..2594
                     /gene="Clstn1"
                     /product="Soluble Alc-alpha. /evidence=ECO:0000250.
                     /id=PRO_0000323602"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1)"
     misc_feature    327..653
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    327..653
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,525..527,531..533,642..644,648..653)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,525..527,531..533,642..644,648..653)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    678..950
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    678..950
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1269..1751
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1269..1751
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1272..1274
                     /gene="Clstn1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6Q0N0.1); glycosylation site"
     misc_feature    1815..2873
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    1815..2873
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    2589..2594
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     mat_peptide     2595..3062
                     /gene="Clstn1"
                     /product="CTF1-alpha. /evidence=ECO:0000250.
                     /id=PRO_0000323603"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1)"
     misc_feature    2676..2681
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     misc_feature    2697..2759
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     transmembrane region"
     misc_feature    2862..3062
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            298..420
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..616
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..825
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..975
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1161
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1410
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1532
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1695
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1853
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2002
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2229
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2400
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2546
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2682
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2867
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..4414
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccgcc gccgccgcct ccagcgcagc gctgccgacg aggggagggc gcgcgcggcc
       61 cagcagcacg gcggctgccg ctcacatccc ggtgctcgcc gcgccgccca gccgctggcc
      121 cccggctgcc cgcacccctc tcggcgtccc gcgcgactcc ctgctgcttc cgcgtcgggc
      181 cggccgcggc gctccgagcc cgagcgatgc tgcgccgccc tgcgcccgcg ctggcccggg
      241 ctgtccggct gctgctggcg gggctgctgt acggcggcgg ggtctgggcc gcgcgagtta
      301 acaagcacaa gccatggctg gagcccacct accacgggat cgtcaccgag aacgataaca
      361 cggtgctgct cgaccccccc ctcatcgccc tggacaaaga ctcaccgctg cgctttgcag
      421 gtgagatttg tggctttaaa atccacgggc agaatgtccc cttcgatgcc gtggtagtgg
      481 ataagtccac gggtgaggga ataatccgat caaaagagaa actggactgt gagttgcaga
      541 aagactatac attcaccatc caggcctacg actgcgggaa gggacccgat ggcaccggtg
      601 tgaaaaaatc tcacaaagca accgtgcaca tccaggtgaa cgacgtgaat gagtacgccc
      661 ccgtgttcaa ggagaagtcg tacaaggcgg ccgtggtgga gggcaagcag cacggcagca
      721 tcctcagggt ggaggccgtg gatgcagact gctcgcccca gttcagccag atctgcagct
      781 atgagattct caccccagat gtgccgttca ctgtggacaa agacggttac atcaaaaaca
      841 cagagaagct taactacggc aaagagcatc agtataagct cactgtcacc gcctatgact
      901 gtgggaagaa aagagccacg gaggacgtcc tggtgaagat cagcgttaag cccacctgca
      961 gccccgggtg gcaaggctgg agcagcagaa ttgaatatga gcccggcaca ggcgctttgg
     1021 ccgtcttccc gagcatccac ttggagacct gcgacgagcc tgtcgcctct gtgcaggcca
     1081 cagtggagct ggagaccagc cacataggga aaggctgcga ccgagacacc tactccgaga
     1141 agtccctcca ccggctctgt ggggctgctg ctggtacctc agagctgctc ccgtcgccca
     1201 gtagctcctt caattggacc gtcggcctcc ccactgacaa cggccatgac agtgaccagg
     1261 tctttgagtt caatggcaca caggcggtgc ggatcccaga cggtgttgtg acccttgacc
     1321 ccaaagagcc ttttacaatt tccgtgtgga tgcggcatgg gccttttggc cggaagaagg
     1381 agacaattct ctgcagttcg gataaaacag atatgaaccg acaccattat tcgctctatg
     1441 tccacgggtg cagactcatt ttcctcctcc gtcaggaccc gtctgaggag aagaagtaca
     1501 ggcctgcgga gttccactgg aagctgaacc aagtctgtga tgaggattgg caccactttg
     1561 tcctcaatgt ggaagtccca agtgtgaccc tctatgtgga cggcgtctct catgagccct
     1621 tctccgtgac cgaggactac ccacttcatc caaccaaaat agaaactcag cttgtggtcg
     1681 gagcttgctg gcaaggtggt gacctgcaca tgacgcagtt tttccgaggt aacctggctg
     1741 gcctcacagt ccgttctggg aaactggcag ataagaaagt gatcgactgt ctgtacacct
     1801 gcaaagaggg gctggacctg caggtccctg aggatggcaa cagaggggtg cagatccaaa
     1861 caagctccag tcaggcggta ttgaccttgg agggggagaa tgtcggagag ttggataagg
     1921 ccatgcagca catttcttac ctcaactcaa ggcagttccc cacaccaggc atccgcaggc
     1981 tgaaaatcac cagcaccgtc aagtgcttta atgaggcggc ttgcatcgag gtgcctccgg
     2041 tggagggcta cgtgatggtt ttacagccag aagaacccaa gatcagcctg agtggggtcc
     2101 accactttgc ccgcgcagct tccgagtttg agagcccgga gggtgtttcc cttttccctg
     2161 agctgaaaat cataagcacc atcaccagag aggtggagcc cgaggcggac ggggctgagg
     2221 accccacagt gcaagagtcc ctggtgtcgg aggagattgt gcacgacctg gacacctgtg
     2281 aggtcacggt ggaaggggag gagctgaacg cagagcagga gagcctagag gtggacgtgg
     2341 cccgcctcca gcagaagggc atcgaagtga accactctga cctgggcgtg gtcttcacag
     2401 gtgtggaaac catggcaagc tacgaggagg ttctgcacct cctgcgctat cggaattggc
     2461 acaccaggtc cctgctggac cggaagttca agctcatttg ctcggaacta aatggtcgtt
     2521 acctcagcaa cgagttcaag gtggaggtga atgtgatcca cacagccaac cccgtggaac
     2581 acgctaatca catggccgcc cagccacagt ttgtccaccc tgaacaccga tccttcgtgg
     2641 acctgtctgg tcacaacttg gccagtcctc acccatttgc agttgtcccc agcacggcga
     2701 ctgtcgtgat tgtggtatgt gtcagcttcc tggttttcat gatcatcctg ggggtgtttc
     2761 ggatccgagc tgcacatcag cgaacgatgc gggaccagga caccgggaag gagaacgaga
     2821 tggactggga tgactctgcc ttgaccatca ctgtcaaccc catggagacg tacgaggacc
     2881 agcacagcag tgaggaggag gaagaagagg aagaggagga ggagagtgaa gacggggagg
     2941 aggaggagga catcaccagt gccgagtcag agagcagtga ggaggaggaa ggcggccccg
     3001 gggacggcca gaacaccacc cggcagcagc agctagaatg ggactactcc acactcagct
     3061 actaaacacg cgctcgccca gcacctgctc tccagactct cccagccatc ttccagcccc
     3121 acgggtccac gatgtacaaa tcattttgac cagcaggtct gcagacccct cccccattgc
     3181 tgaaagtcct cccgtgcttg gtgtgtggga ccacaggctc cgccctccct gcccatcacg
     3241 cttgcagttt tgcttaggag ctggcccttc ctcccagtgc aggggcccca cagcacctca
     3301 gaccccaagt gtgtctggag tcccctgtca gccagggaga ggacaccagc acctgggacc
     3361 tccagagaag ccgcagtgag cggacttgtc gacagagggt aaaaaattac tcccacgcag
     3421 tcatcatttt tcttcatttt taaaagtttt tatttttatt ttccaatata gtgcatgtat
     3481 aaagtgggag agcggggagg gggggttaat atgtagatga ccaactgact ttttaatatt
     3541 ttgtaaataa attgggattc tttgtgtcct ttgtgctagt gtagtccagg acaggaatgt
     3601 gaagtcagaa catggggcca ggaagagctc ttcctccctt ttccctccca agaaaccagg
     3661 ttggaaaggt ccaagtcaca gtggcccatg ctggggtttc tgtacagcca tgtggccagg
     3721 gccataggtt ttgagtgctg cctgggggag ccagacccac gcgctcccac cacattagag
     3781 gctgggaaca gccaggatgg tgccaaagcc cctggccttc cttgtacacg cctgtgacca
     3841 gcctcgtggc ttctgctaat tagcgtgtct ccctgttggt gaaaacctgt agctgggaac
     3901 tgatggcaaa gatggacaac agttctgagc agtctgcact acagcaccca agaggagaac
     3961 ctgaggcccg aaaacaaact gctacaatgt ttcaaaacga gctgcgctct cctccccaga
     4021 gaccccacgg gatgcccccg ggatgccccc ttgctgtcgg gttttggcta agacctaaga
     4081 cccagcagag gagagccagc cggcttgggg ggtgggggtg ggggaggaga cagcagctaa
     4141 aacccacaca gcacggcttg tcattcacag tcacagttta gactcctcca gctggggaat
     4201 ccggtcctcg ctgctagtcc taaggatgtt gacgctgtgc tgcctgtggc caccctcccg
     4261 tgtcctgttc cctgtagtcg ctttatagat ggaaacaggc tatgaagagg gacactgtcg
     4321 tgtgttggta gccgcaggct ccccttaaga tgtgtatatt gaccccaggt caggaagtgt
     4381 atgcgttata ataaagttct ggttctaact ccaa
//
LOCUS       NM_001436907            1760 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus ring finger protein 215 (Rnf215), transcript
            variant 2, mRNA.
ACCESSION   NM_001436907 XM_063273206
VERSION     NM_001436907.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063273206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.1602318.1,
                                           SRR26360194.598409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000014.1  83230282-83230636
            356-499             JAXUCZ010000014.1  83230878-83231021
            500-571             JAXUCZ010000014.1  83231620-83231691
            572-657             JAXUCZ010000014.1  83231772-83231857
            658-814             JAXUCZ010000014.1  83232255-83232411
            815-958             JAXUCZ010000014.1  83234888-83235031
            959-1061            JAXUCZ010000014.1  83235186-83235288
            1062-1760           JAXUCZ010000014.1  83235375-83236073
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1760
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="ring finger protein 215"
                     /db_xref="GeneID:305478"
                     /db_xref="RGD:1310738"
     exon            1..355
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1084
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="RING finger protein 215 isoform 2 precursor"
                     /protein_id="NP_001423836.1"
                     /db_xref="GeneID:305478"
                     /db_xref="RGD:1310738"
                     /translation="MGPADRPALRSPSSPPPPPSPPSPLLLLLPLLPLWLGLMGPGAA
                     ADGSEPEARAGRGGARAVRVDVKLPRQDALVLEGVRIGSEASPEPLLGGRLLLMDVVD
                     AEQEIPADGWIAVAYVGKEQVAQFHQENQGSSQKAYPKALVQQMRRALFLGASALLLL
                     ILNHSVVRELDISQLLLRPVIVLHYSSNVTKLLEALLQRTQATAEISSGESLSANIEW
                     KLTLWTTCGLSKDGYGGWQDLVCLGGAQAQEQEDLFKRRVVRRLASLKTRRCRLSRAA
                     HSLPEPGAETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGN
                     HYSDD"
     sig_peptide     65..199
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    917..1066
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 215 (RNF215) and similar proteins; Region:
                     RING-H2_RNF215; cd16670"
                     /db_xref="CDD:438332"
     misc_feature    917..1066
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 215 (RNF215) and similar proteins; Region:
                     RING-H2_RNF215; cd16670"
                     /db_xref="CDD:438332"
     exon            356..499
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            500..571
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            572..657
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            658..814
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            815..958
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1061
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1760
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcggttct cctggccccc ccgcggacct tagactacgg cctcaccacc tctccggtcc
       61 ggtcatgggc ccggccgatc gcccggcact gaggtcgcca tcttcgccgc cccctccccc
      121 atcgccgccg tcgccgctgc tgctactgtt gcccctgctg cctttgtggc tgggcctgat
      181 gggtcccgga gccgcggcgg acggcagcga gccggaggcc cgggctgggc ggggcggagc
      241 ccgcgcagtg cgggtggatg tgaagctgcc gcggcaggac gccctggttt tggagggtgt
      301 caggatcggt tccgaagcga gtccggaacc tctactgggc ggccgcctgc tgctgatgga
      361 tgtcgtggat gctgagcaag agatacccgc agatggctgg attgcagtgg catatgtggg
      421 caaagagcag gtcgcccagt tccaccagga gaatcaaggc agtagccaga aggcatatcc
      481 caaggctctg gtccagcaga tgcgccgagc ccttttcctg ggagcctctg ccctgcttct
      541 cctcatccta aaccacagtg tagtccgaga gttggacata tcccagctcc tgctcaggcc
      601 agtgattgtt ctccattact cttcaaatgt caccaagctg ttggaagctc ttctgcagag
      661 gacccaggct actgctgaga tcagcagtgg agagtccctt tcagccaaca tcgagtggaa
      721 gctgacattg tggaccacct gtggtctctc caaggatggc tacggtggct ggcaggactt
      781 ggtgtgcctg ggaggtgctc aagcccagga gcaggaggat ttgttcaaac gccgtgtggt
      841 tcggagacta gcatccctca agacccggcg gtgccggctg agcagggcag cacacagcct
      901 tccagagcct ggcgctgaga cttgcgctgt ctgtcttgat tacttctgta acaagcagtg
      961 gctccgggta ctgccctgta agcatgagtt ccaccgagac tgcgtagacc cctggctgat
     1021 gctacaacag acctgcccac tgtgcaagtt caatgtcctg gggaaccact actcagatga
     1081 ctaactcccc agtggagagt ctgcacatcg ggatggaccc ttcccagcct acactacagg
     1141 agagtgggat gggcagacca gctagccctg tgggcaaagg aaaggttccc accatgccca
     1201 tgatggatag gagggactcg cacctccagg ctgaagacac agagccagga cccagcaggc
     1261 aaggagaaat cattagagcc cttctctgca aacctggggt attgtgtctg tcctcatagg
     1321 cagctcccac aactctggga aagaaaatat ggccactaca tctgtccaca gcactctgga
     1381 gcttcggtgt tgaattttat gctatttatt gagggagaat atgtgtggcc atgggaccca
     1441 ctggcatgac cgtgtctttc gggccatggc ctaatcaaat caaagatgac gttaaagtga
     1501 gcctgctcca ctccctgctg cccgtccagc tggattcctc cagtctgact gggatcagag
     1561 gccttagaaa ccatctagtg ctgtatttct tggttggcct aaatgttact gcaggatact
     1621 tgaggccaca gaatacatgt ggtgcatctg ccaagggcat cattacaaga aaaaaacaaa
     1681 aacacaaaaa caaatgtttg ggtagggaag ttttaatagt aaaataaaca tggagtatat
     1741 tttaacatat aagacataaa
//
LOCUS       NM_001436884            4234 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 10, mRNA.
ACCESSION   NM_001436884 XM_039094620
VERSION     NM_001436884.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4234)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 4234)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039094620.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2681282.1,
                                           SRR26360176.1269646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-4234           JAXUCZ010000016.1  17513109-17515061
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4234
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2341
                     /gene="Eps15l1"
                     /note="isoform 10 is encoded by transcript variant 10;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 10"
                     /protein_id="NP_001423813.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKLPGPVGRLLKTAALHPAPE"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..4234
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 gctcccaggc cctgtgggaa gacttttaaa aacagcagcc ttacatccag cacctgagta
     2341 ggaaagagcc agttccagag actgagaagc ctaatactgt cagaacagct ccaagggggc
     2401 ccaatctcag cacctgggag gcaaaggcag gtggatctct gtgagatcaa ggctagcctg
     2461 gtctacataa tgatttagac catccaagga tacacagtga gacatttcca aaaaagaaag
     2521 aaagaaaata ataaagtgaa cttggagtgg aatattgcct ggcgttgtgg acagagcccg
     2581 tatgagggga gccaggctga cacagtcaag cctgtccctt tcaaggtaac agatagttcg
     2641 gtggacttaa gcccccaggg gaggtgacat ctgtctggcc tgggacgttg cagccacctg
     2701 gtgagtcaag caatactggg tcctgtgtgg attagaaagt agaactgctt aggccctcat
     2761 cctcctgcct gtgactcagg agacctgtcc caagaaacat cctaagacca agaaacctca
     2821 tctgtactgc agccttctct gccgttaggc tcctggattt cagaccctgg actcaggacc
     2881 gagtacacac gggcttgagc gcttacgcac cgtcagctaa cgagtacctt tttttctttt
     2941 ttcttttttt cggagctggg gaccgaaccc agggccttgc gcttgctagg caagtgctct
     3001 accactgagc taaatcccca accccacgag tacctttttg ttttctttat taaattgcat
     3061 ttctttgggg gcagggtatc atggcaccca tgtgccaagc ttgagtcaat attttttttc
     3121 caccatgtga acccagggat tcaggtcact aggcctgctt gcaagtttat tgagccatct
     3181 ctccagcatc aaaagatact gagtggtaca catctctcat cctgcatctt gtctggaggc
     3241 tagagtagca tgcatttgag ggcagcctca ggttatagca agaccctgtc tccaaaaaac
     3301 aaaacaaaac aaaaacaacc actaacctgt agatgaccct gttctatctc ttcccagtcc
     3361 ccaaggcagg aggagttgag agtctgtaga cataagcttc agaaagaggt gggatcgccc
     3421 acatgcctca cgatacagaa gtgtcctctt agcctgtgag gacccatctt gggagccctc
     3481 ccccagtgga tgcctgaccc tgtgttcact gctccctttg cacttctgga aaagcatgac
     3541 ttgtaaacaa ggaacagttg gcaagtggaa gagtcacagc atgctgcagt aaaagttatt
     3601 tcagactcag gaactgtttt tctggaacct tttcctcttc atgttctcag catgatggac
     3661 catgacatga caaggtgggg cagctgtagt cactgtgcca tctctgctgg tctgtccgtc
     3721 acagtacaga tggggaagca agcaaggcac aggcagttgg actgggattt cagcccaggt
     3781 tgagtaaccc agctcacctc tgaccacagg ggcctgcagc ctgaccagga tgatctggaa
     3841 acttccgtgg acaagctttg aattaagatt ctgccatttg tgtataaaga cttgagagtg
     3901 ttcttagtag agtctctact cctccctgct ctgcagcctg acagcccgcc aggccttcct
     3961 gcatgaagct cctagctcta cagaataagg atttgggggc gggggagggg gggtctggtt
     4021 aggtctgtga atctagaggg gtgggggtgg gggctggaga gatggctcag tggttaagag
     4081 cactgactgc tcttccagag gtcctgagtt caattcccag caaccacatg gtggctcaca
     4141 accatctgta atgggacctg atgccctctt ctggtgtgtc tgaagacagc cacaatgtat
     4201 ttatatataa taaataaatc tgtttttaaa aaga
//
LOCUS       NM_001436916            7424 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 4, mRNA.
ACCESSION   NM_001436916 XM_008763548
VERSION     NM_001436916.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7424)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7424)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7424)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7424)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7424)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7424)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_008763548.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.334257.1,
                                           SRR26360176.363230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000005.1  31992696-31993092
            398-535             JAXUCZ010000005.1  32078977-32079114
            536-777             JAXUCZ010000005.1  32081132-32081373
            778-867             JAXUCZ010000005.1  32085402-32085491
            868-1049            JAXUCZ010000005.1  32089757-32089938
            1050-1300           JAXUCZ010000005.1  32102023-32102273
            1301-1386           JAXUCZ010000005.1  32107640-32107725
            1387-1588           JAXUCZ010000005.1  32108284-32108485
            1589-1657           JAXUCZ010000005.1  32117199-32117267
            1658-1848           JAXUCZ010000005.1  32122846-32123036
            1849-7424           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7424
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..397
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2124
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform b is encoded by transcript variant 4;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform b"
                     /protein_id="NP_001423845.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MNTKRRCGGRAAGRLARSPPEGNLRGRAGGGGAGRGVGAAPQRS
                     RADKSQGSEDVTCYRELLLAARGNLHLKITEGEGEDLPFVVLGEEEAAALASLLSPNT
                     SAIQTGTRGDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTN
                     GTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQF
                     GNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQR
                     ELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENG
                     FDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHH
                     YRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMV
                     EKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSGSSSHSRQQSPVNPDPVAL
                     DAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERA
                     KMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHK
                     DWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIE
                     TTPR"
     misc_feature    673..942
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    673..942
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1318..1518
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1318..1518
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1636..>1800
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1636..>1800
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1852..1962
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1852..1962
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            398..535
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..777
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..867
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1049
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1300
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1386
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1588
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1657
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1848
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..7424
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcacacac aatgtgccat ccccaccagc cctttacttc tgataagctc cgatgtgtgt
       61 ttaatgaata caaagcggcg gtgtgggggc cgcgcggccg gccgcctcgc gcgctcgccg
      121 ccggaaggta atctccgcgg ccgggctggg ggcggcgggg cggggcgcgg cgtgggggcg
      181 gccccccaac gatcccgagc agataagagc cagggaagtg aagatgtaac ctgttatcgg
      241 gagctcctct tagctgccag agggaattta catttaaaga ttacagaggg agagggagag
      301 gatctgcctt ttgttgtgct gggtgaggag gaggcagcgg ccctggcctc cctgctatct
      361 cccaacacct ctgctatcca gacggggact cgcggagatc gtaccgagaa gcactccacg
      421 atgccagact cacctgtgga tgtgaagacg cagtctaggc tgactccccc agcaatgccg
      481 cctcctccga ccactcaagg agccccgaga accagttcgt ttacgccaac gacattaacg
      541 aatggcacca gccattcacc cacggccttg aatggcgccc cctcaccgcc taatggcttt
      601 agcaacgggc cttcctcttc ctcttcctct tctctggcta atcaacagct gcccccagcc
      661 tgtggtgcta gacaactgag caagctgaag cgatttctta ctaccctgca gcagtttggc
      721 aatgacattt caccagagat tggagaaaga gttcgcactc ttgtactagg actggtgaac
      781 tctactttga caattgaaga atttcattcc aaacttcaag aagctactaa cttcccactg
      841 agaccttttg tcatcccgtt tttgaaggcc aacctgcccc tgctacagcg tgaactcctc
      901 cactgcgcaa ggctagccaa acagaaccct gcccagtacc tcgctcagca cgaacagctg
      961 cttctggatg ccagcaccac ctcccctgtc gactcctcag agctgcttct cgatgtgaac
     1021 gaaaacggga agaggcgaac tccagacaga accaaagaaa atggctttga cagagagcct
     1081 ttgcactcag aacatccaag caagcgacca tgcactatta gcccaggcca gcggtacagt
     1141 ccaaataatg gcttatccta ccagccaaat ggcctgcctc accccacccc acctccacct
     1201 cagcattacc gtttggatga tatggccatt gcccaccact acagggactc ctatcgacac
     1261 cccagccaca gggacctcag ggacagaaat agacctatgg ggttacatgg cacacgtcaa
     1321 gaagaaatga ttgaccacag actaacagac agagaatggg cagaagagtg gaagcatctc
     1381 gatcatctgt taaactgcat aatggacatg gtagagaaga cgaggcgatc cctcactgta
     1441 ctaagacgat gtcaggaagc agaccgggaa gaactgaatt actggatccg gaggtacagt
     1501 gatgctgagg acttgaaaaa gggcggcagc ggtagcagca gccactccag gcaacagagc
     1561 cccgtcaatc cggacccagt cgcattagat gcacatcggg aattccttca caggcctgcg
     1621 tctggatacg tgccagagga gatctggaag aaagctgagg aggctgtgaa tgaggtgaag
     1681 cgacaggcaa tgacggagct gcagaaagcc gtgtctgaag ccgagaggaa agcccatgac
     1741 atgatcacca cagagcgagc caaaatggaa cgcacggtgg ctgaagccaa gcggcaggcc
     1801 gcagaggatg ctctggcagt catcaaccag caggaagact ccagtgagag ttgctggaac
     1861 tgtggccgga aagcaagtga gacctgcagc ggctgtaaca cggcccgata ctgtggctct
     1921 ttttgccagc ataaagactg ggagaagcat caccacatct gtggacagac cctgcaggcc
     1981 ccacagcagg gagaaacgcc tgctgtcagc tcctcagtca cgcccagcag tggggctggg
     2041 agcccaatgg acacaccacc agcagccact ccgaggtcta ccacccccgg aaccccctcc
     2101 accatagaga cgacgcctcg ctagacctaa actcagactg tcagaggaaa gacaccacaa
     2161 ccaacacgaa agcaattcct catcctcaga tgctcaaagt cccttttctg tttgtttgtt
     2221 tatagatgaa ctatctatct tatttcagta cttcggcaag agagaaccta actgtatctt
     2281 tgaggcgata gtaaaacaca gaggccagta acgggtcgta atgacttact gtggaaaaca
     2341 aagatatctt ttctttagag aactgaaaag agaggaaaga atataacgtg aaatgctaga
     2401 tttgacctcc tccctgttat tttcaagtag ctgggatttt aaactagatg acctcattaa
     2461 ccaatgcttt accaaacagc aaaccaagag attgctaatt gctgttgaaa gcaaaaatgc
     2521 taatattaaa agtcacagtg ttctttatat acaataatgg aaagaaaaaa aaaaaagagg
     2581 caattcctca agggcacgag cgttggatac agcagtagac attttaacaa gaagatgaat
     2641 ggcgtctgtg ggttgctaac tgaactttga agaccggctg caaaacgcac agatgtgcag
     2701 cagattggaa ggagacacag atgttcgttt tttttccccc gtttctgaaa aagaaataat
     2761 aatatccagg tcaacagaat gaaaaatgaa agatgatttc cagtggggtg tatgactaca
     2821 gcagcaagaa aaaaaaaatt gccataatac aaaggctcct ttttatatca cacacacaca
     2881 cacacacaca cacacacaca cacacacaca cacacacact cactctctct ctccctctct
     2941 ctctctctta agagactcag cctgcagtta attagcattc tggcagcttc caagtcagcc
     3001 agctgcccta aataaccctt caacgtttct tcacttttgc aaggttccac agagtaagac
     3061 attgaatcta ttccagctta ttcattttat atcgaaaaac caattttttt aaaaaaaaaa
     3121 atggcggctt cagctccagc ccctttccaa aatttttcaa ccccaccctg tttgggtttt
     3181 taattaaaat ctagtagttc tcttggtatt aaaacacttc tgtcctgtga ggttttccca
     3241 atggtgtttt tcttgtaaat gtgttggaca aatgtgaaga tgcgttgtag ttgatccata
     3301 tgcccacatt tagtctcttt attcctagtt ggtgagagaa accagtatct ttctatgctg
     3361 cttttatatc tgtatgtatt agtgatattt ctctagtagt taaaaaaaaa aaatgaaaag
     3421 aaaagaaaaa aaaaaaccac actttttttg gttgtcctca agaaaagaag aaaagaaaag
     3481 aaaagaaaaa gctatctttt ggagctgcta actcactctc ttataggatt tttttcctgg
     3541 aaaccagcat gcttcatgga atgctagcac atggatgttt ttaagaggga tgtacataaa
     3601 tgtattttgc actgtcacaa tgactcccta ggcatgcttt ttttttttca aaccaacttt
     3661 ttaaatatgc tagagccatt tcaccaattt tagctgtagc atagagtagt agtggaattt
     3721 ttcttttatc ctttttttta tgaaaaaaaa aattattagg gactttttaa aaaaaaataa
     3781 aataagatat cctactttaa aaaaaaagga cagtgcatgc atattgctgt aaggttgttt
     3841 aagtatttct aattttacaa aaaaaaaatg aaaaaaaaaa tcattagctc tccaaatgct
     3901 gaggtgtaga cggacagctt tagccctgct gagtgccagg ttatacagta ttcttacaaa
     3961 agggaagtca gccaaagact gatctgatgg accaaaatcg gaatttttga aaagcaccag
     4021 taatcctttc caaatgatca gcaggttaaa catgttcagt gtgactccat taacccttcg
     4081 ttgtccaggg tccagaccag aactacttgt tagttttgaa acacattatt agcccaggat
     4141 gtggttgtgt gctttaagag tcggcagtgc tgcaggctgt gtagacaacc aaagttgaaa
     4201 ggctgggaag acacttttcc acatacacat acaccaggca tttctttaca aaattgagta
     4261 caatccatta gcttgtggga ggggggagcg ggtaatgtag cccttggata cagttttaag
     4321 tggttgtgtt ttaagttttc tgcatagatg caatcctcac gggattgctt catgtctcgc
     4381 aaatctaagg tttccttaaa ccatttcccc tgtattttca tataccagtc ggttttgatt
     4441 ttgtcccggt agtgttgtgt tcttttctct tgtcgtcgtc gtcgttgttt tcaatggcct
     4501 tttagtttag gaagttctga tgagcgaatc aatgcatcta tctatctgca tgttggaagt
     4561 ccatctgcca gcacacccgc taaggcaaag agaagcgcat aaccaggctg cgaatgggtt
     4621 ctattttacc atggtgctcc cagaatcctt tgacctcatt ctgctttcta gtctgcttgt
     4681 gacactggac agtcctttct tagagctatt atatgttcta ggctacgaag ggttaaataa
     4741 tcccaaaaaa aataacaaaa aaaaatgagg tatgtcatac cctcgcgtct cgatctcaag
     4801 aagctgtgat gtatgtggaa cagcactgtt attctgaaca ctagtgtgta aaataaggat
     4861 tagtacagta cgtctcattc cttttttaat tcagggcacc ctgagtgaaa accaatacaa
     4921 aaaaaaaaaa aaatccctaa ctctgagctc tgtctctaat tcctcttcct ccttcccctc
     4981 ttcctcctcc tcttcctcta ctcctgtttt gctacattct cctcagtggc aaaaagtttc
     5041 actctacctc tgacagcatg tatattgcac cagtcgctaa cgaaaactgg tctagtcaaa
     5101 ccaaatgggc acaaaagaac caggatacca aaagttaagc tcatacagct gcgaaccata
     5161 tcacttcttg gtaacaatgc agacctcata aacctaaaaa aaaagagaaa gaaaagaaaa
     5221 cttttgttac tttccttttt tgcttgtcac ttatatacag gctatgtgag agtattcatt
     5281 tgtaggtatt acacattaaa aaaaaaaagc tatcttcatt ggatagaact gaatggtggt
     5341 cgctgatagg aatagggcgt cctctatctc ttatctctgt ctcttttctc tttctctttc
     5401 tctgtcatga gactgtgtgt gacagggcta cctgtctttt taatttgttt tctgaacttt
     5461 ttttttttaa tgtgtaggtg catgtcttgg ggatttaaaa atttcaaggc tggtttactt
     5521 atgcaaagca tgcctatgtc tggaatactt agggaaagaa agtgactcca tgttgtccga
     5581 attcctcaag ggacagaaaa acaaattgga gactgttgaa atgcagattt gaagtaattt
     5641 tatttttaat tattttgggt tctgcgacat tattgtgaaa aattaaagtc gttgtgcaat
     5701 acttaattca gacacgtgcc acaagttaac ggtagactaa cactgggggg cgggggctag
     5761 gcatcacgct tttgtctgca tactcttgag cttttaagtc tactatgtct gaactgtggt
     5821 ttcttgttta tccttttttg ttttttcctt agttggactg taatgtatgg tctgtcaacc
     5881 tgtgaatctt taaagtatga ttcaggtatt gttgtactct ttaccgtgta ataaaaatgc
     5941 ttaaaaaaaa aagtcagtag tccgtctccc ttatctttac tgtgtgcccg ccaaggctac
     6001 cactcaggaa cctcattctt gaagggcagt tcttcatgga gcatgcccag agtctagtca
     6061 gctacagagt atgtctctaa cgtgttaatt cgcccacgag tgatgaggga gaaggagaga
     6121 acacagagga catttctgag gtcatagtag tccaatatag aaggatactc caagtcctcc
     6181 ataagaaagg atagcttatg ctaggggtca ccgtctccag aaaggtccaa ttgccatctt
     6241 tttaaactct ggcttgcagc atgtttcttt cattctcagc tgcaggatgt acccactaag
     6301 gcagatctct tcctccatct gtcctggatc ctcaccgcct ttaattagaa gttgccagca
     6361 tgttcacact tggttttgta catttgtaaa tacacagtat gttgtgtcca tcttgtttct
     6421 gagacccatg ttgtccattt aacacgcacc agtatatttt ttttcatgca ctagctataa
     6481 aaaataactt agactttgga gaacctattg gtcatctacc atagaaactc agtcaatttt
     6541 cacgtacttt acacaacaca ttttttaatg actgtatata ctgcattgta gcagaatttc
     6601 tgatttgctt ggaagattcc cgctatggcc taaaactagc ttaaagggat caagtgaaat
     6661 gcaagaactg aatctggaga gacagagaag tcacatagac gctgtcgagt gggaggataa
     6721 cctagggcct tctcttcagt ttcctttgta cgccagctag gcccctatgc ctgtcctgag
     6781 gcctggcttc tccaaatgat gttgagaaat gcagcctatt ttacagagtg aggaagggag
     6841 cggggaaggg agggagggag gagggagaaa gagagagaga gagagagaga gagagagaga
     6901 gagtttaaaa gcatagctag tgcgtatctt attcctacaa aataaacagg ctgagtattt
     6961 agttttgtag ttaatttttc ccctcactcc aaagcctgac cagcgtggct caacttgctt
     7021 ttcttatttg tacagataca ttttcttttt cttttcaaag tggaacagac cagaaaccag
     7081 aagacatgga ggacataact gagatgcctt gaagtagccc ctttataagc tgtccttgaa
     7141 aaacagctct gtgacctatt tgtatgactg gattgctaga caaatgagta atgagtttag
     7201 tttagaggaa gaatgtgaac aaaatcagct tctgggtggt aagcaccatt ttttaaaaga
     7261 atgtaattga tgtatttgat aatataaaaa tgatgtttgc catgaaagaa cactaagtta
     7321 tttccccaga ttggaagggg aagaaatgat caaagaggtg cttttctgta tgggtattta
     7381 tatctttatt tcaaggtgaa tgaataaagt tgtacttgcc taaa
//
LOCUS       NM_001436909            3917 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus thymocyte selection-associated high mobility
            group box (Tox), transcript variant 3, mRNA.
ACCESSION   NM_001436909 XM_006237844
VERSION     NM_001436909.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3917)
  AUTHORS   Artegiani,B., de Jesus Domingues,A.M., Bragado Alonso,S.,
            Brandl,E., Massalini,S., Dahl,A. and Calegari,F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
REFERENCE   2  (bases 1 to 3917)
  AUTHORS   Yun,S., Lee,S.H., Yoon,S.R., Kim,M.S., Piao,Z.H., Myung,P.K.,
            Kim,T.D., Jung,H. and Choi,I.
  TITLE     TOX regulates the differentiation of human natural killer cells
            from hematopoietic stem cells in vitro
  JOURNAL   Immunol Lett 136 (1), 29-36 (2011)
   PUBMED   21126536
REFERENCE   3  (bases 1 to 3917)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   4  (bases 1 to 3917)
  AUTHORS   Aliahmad,P. and Kaye,J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
REFERENCE   5  (bases 1 to 3917)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   6  (bases 1 to 3917)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006237844.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.26530.1,
                                           SRR26643429.18799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000005.1  24967949-24968025   c
            78-213              JAXUCZ010000005.1  24967582-24967717   c
            214-279             JAXUCZ010000005.1  24822463-24822528   c
            280-522             JAXUCZ010000005.1  24803320-24803562   c
            523-804             JAXUCZ010000005.1  24722995-24723276   c
            805-1035            JAXUCZ010000005.1  24706495-24706725   c
            1036-1116           JAXUCZ010000005.1  24694150-24694230   c
            1117-1500           JAXUCZ010000005.1  24681968-24682351   c
            1501-1652           JAXUCZ010000005.1  24674144-24674295   c
            1653-3917           JAXUCZ010000005.1  24671564-24673828   c
FEATURES             Location/Qualifiers
     source          1..3917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3917
                     /gene="Tox"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
     exon            1..77
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            78..213
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    97..99
                     /gene="Tox"
                     /note="upstream in-frame stop codon"
     CDS             112..1689
                     /gene="Tox"
                     /note="thymocyte selection-associated HMG box"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_001423838.1"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
                     /translation="MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPVSQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMQEIGNAEGAQYSSHPQLAAMRP
                     RGQPTDLRQQASMMQHGQLTTINQSQLSAQLGLNMGGTNVPHNSPSPPGSKSATPSPS
                     SSVHEDECEDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYNDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQPLVQQPLASQLPM
                     QVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWST
                     DYCSSGGMQRDKALYLT"
     misc_feature    895..1104
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    895..1104
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    order(895..900,904..918,925..930,949..951,985..990,
                     997..999,1006..1011,1030..1032,1042..1044,1051..1053,
                     1063..1065,1072..1074)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     misc_feature    order(895..900,904..918,925..930,949..951,985..990,
                     997..999,1006..1011,1030..1032,1042..1044,1051..1053,
                     1063..1065,1072..1074)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     exon            214..279
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            280..522
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            523..804
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1035
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1116
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1500
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1652
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..3917
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttacct gcccggcggc gggccgagag cgccggggcc gagcggacca ggcaggctgc
       61 gcgctcggcg tggacgggaa aagaaaagga gttgcttgat gtgagagtga aatggacgta
      121 agattttatc cacctccagc ccagcccgct gctgcgcccg ccgctccctg tctgggacct
      181 tctccctgcc tggaccccta ctattgcaac aagtttgacg gtgagaacat gtatatgagc
      241 atgacagagc cgagccagga ctatgtgcca gtcagccagt cctaccctgg cccaagtctg
      301 gaaagtgaag actttaacat cccacccatt actcctccct cactccctga ccactctctg
      361 gtgcacctga atgaggtgga gtccggttac cactctctgt gtcaccccat gaaccacaat
      421 ggcctgcttc cattccatcc acaaaacatg gacctgccag agatcaccgt gtccaacatg
      481 ctgggccagg atggcacact gctctccaat tccatctctg tgatgcaaga gattggaaat
      541 gctgaaggag ctcagtacag ttcccatcct cagctggcag ccatgaggcc gagaggccag
      601 cctacagacc tcagacagca ggcaagcatg atgcagcacg gccagctgac caccatcaac
      661 cagtcacagc tgagcgcaca gttgggcttg aacatgggag gaaccaacgt cccacacaac
      721 tccccttctc cacctgggag caagtctgca accccttcgc cttccagctc ggtgcatgag
      781 gatgagtgtg aggatacctc caagatcaat ggaggagaga agcggcctgc ctctgatatg
      841 ggaaaaaaac caaaaactcc taaaaagaag aagaagaagg atcctaatga gccccagaag
      901 cctgtgtctg cctatgcttt gttctttcgt gatacccagg ctgccatcaa gggccaaaat
      961 ccaaatgcta cttttggtga agtctctaag attgtggcat ccatgtggga tggcctagga
     1021 gaagagcaga aacaggtcta caagaagaaa actgaggctg caaaaaagga atacctgaag
     1081 cagctagcag catacagagc cagccttgta tccaagagct acaatgaccc tgtggatgtt
     1141 aagacatctc agccacccca gctggtcaac tccaagccgt cagtgttcca tgggcccagc
     1201 caggcccact cagctctgta cctaagttct cactatcacc aacaaccagg aatgactcct
     1261 cagctcaccg ccatgcatcc gagcctcccc agaaacatag cacctaagcc caataaccaa
     1321 atgccagtga ctgtctccat agccaacatg gctgtgtccc caccaccgcc cctccaaatc
     1381 agcccacctc ttcatcagca tctcagcatg cagcagcatc agccacttgt gcagcagcct
     1441 cttgcgagtc agctccccat gcaggtccag accgccttac actcgcccac catgcagcaa
     1501 ggatttactc tccaacccga ctatcagact attatcaacc ctacatctac agccgcacaa
     1561 gttgtcaccc aagcgatgga gtacgtgcgt tctgggtgca gaaatcctcc cccacagccg
     1621 gtggactgga gtaccgacta ctgcagtagt gggggcatgc agagggacaa agcgctgtac
     1681 ctcacctgaa aatctcaaca cctctccttt ccactgagga attcagggaa accttttcac
     1741 cacggattgc tttggccgct caaagcagtt cttcatttta ttagaaaata caagttgcta
     1801 agcacttagg accatgtgag cttgtgggtc acccacgctg gaagaaatag tcatgcttct
     1861 ttattatttt tttaatcttt tatggacatt gtccctcttc cctgaaggaa gtatgggcca
     1921 ttcagatttc tgttggtttt gctgtgaagt gctgccgctc tagtaactgc cttagcaacg
     1981 gtagatgtct ggggtaaaac ggtcctgggt tttccattgg ttttcataat gggtgtttat
     2041 atgaaactac taaagacttt ttaaatggct tgatgtagca gtcatagcaa gtttgtaaat
     2101 agcatatatg ttacactctc ctagagtata aaatgtgaat gtttttgtag ctaaattgta
     2161 atttgaaact ggctcacccc agtttgttga tttcagaggg gttaaattgg caaacattca
     2221 tatttttact tcatttttaa aaagaaaaaa aacaactgac tgatagttct atattttcaa
     2281 aagacttgaa aactattccc aaatcatttt aatttaaaaa caaattggct ttgtcttatt
     2341 gatcagacaa aaggaagctc tcgtgtggag ggaagcgcaa acacatttat tttgtattgc
     2401 aggaaaaaaa ttcttttttg tatcactttt gtgtaatggt tagtaagcgt catctaagtc
     2461 cttttatgta taaaactgcc aaatgctcgc ctggtatctt agctgcagaa acaggtcaaa
     2521 cagcgctaag tgatcaccgt tacctgtggc tctgtgttac tgttccctca tccgtgtctg
     2581 tatttaatcg ttttcttctc tttttttttt aatgaaactt gtttcgctta tttatgaaat
     2641 aataaatata ggtgtttgta agtaaatttg ttagtatttg aaagaggttt tgttgatgct
     2701 ttaatttttg ctggcaaaaa agaaaaaaaa tccatgcttg gtgtgaatat ttagttttta
     2761 cagtgacatg aataaaacca aaactgcttt tcatttagta gcaaaataga gtgacgaatc
     2821 tgtatttttg catatctttt gttgacataa atgaaaaaca attctactta gccatcttct
     2881 tctcttgaac aatacaacag aaaattgccc tggagatctc acacttgcca agcctaagca
     2941 aacaccagtg catcccgttc ctaaaaagat acgaagagct atttttcact tctccattcc
     3001 aaaacattta accaccacca ccacaccaca cacacccgct aaaaaccaaa ttcaagttga
     3061 gtcactcaaa attcctcaag ccacatgctt ctcatagcat gcagaaaaca tttaagaatt
     3121 gaccaagggt tcaggaagag gtcaaagaag gatatcatgt ctaggatcaa tctagaaatg
     3181 aaggactagt aaccagatca gctatagaaa taggaaaaac atggaaaccg gaagcagttg
     3241 ctagaaactg tgaaatctgc tgtccctctc ccctctactc tcttcttcct cttctatgca
     3301 tcctgagtcc ctgtaagaga tttgcctgaa ggtgtttgca tagttctgat agcagaaggg
     3361 aagggtgagg aaatgtttcc cttccacggg cttctgtcac gtaaattcat ctggctggac
     3421 atgaagagaa tgattgtttt gcggaatgaa ataacctcaa caatttaaat acaaatatat
     3481 catgtaatcc agtcaaaatt aaaaagacaa aagtcttgct tgctttggat tggtttttca
     3541 gacactgtgc gagttgaatc acttggcatg taatgactaa taaataatgc acattcagtg
     3601 ttattattaa aatggccggg gtcgagagct caaattttcc tgtcttgata ctgtataaga
     3661 attcgtgtga ttaacttccc agtttattgt ttggctgttt agtattttag aaatatacca
     3721 gcattattaa ttaactaatg ccttttatta ttgtattatg ataaaatatt actttctcct
     3781 acattaagtc caaactgaga agagtccgac cagctaagat aagaggtgta tcaggagatt
     3841 gtctgcagct tttcctggca ggcgaaaaga aaaaaataca tcaaatgtga aataaattat
     3901 caattaaact ctcactg
//
LOCUS       NM_001436939            1093 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 7, mRNA.
ACCESSION   NM_001436939 XM_006238081
VERSION     NM_001436939.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1093)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 1093)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 1093)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 1093)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 1093)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 1093)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 1093)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 1093)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 1093)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006238081.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228666.1, AW530079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-775               JAXUCZ010000005.1  61737892-61738666   c
            776-908             JAXUCZ010000005.1  61737621-61737753   c
            909-1093            JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1093
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..775
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    649..651
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             706..1065
                     /gene="Ccl27"
                     /note="isoform d precursor is encoded by transcript
                     variant 7; C-C motif chemokine 27; chemokine (C-C motif)
                     ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform d precursor"
                     /protein_id="NP_001423868.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MEGLSLTGSLPLILLLLSPVPEAALPLPSSTSCCTQLYRQPLPT
                     RLLRRIVRVELQEADGDCHLQAVVLHLTRRSVCVHPQNRSLARWLERHGKRLQGTLPS
                     LNPVLQKKMCPSPQKQK"
     sig_peptide     706..774
                     /gene="Ccl27"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    796..978
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    796..978
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            776..908
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1093
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcaccaa agaacttttc tcttcctcgt ctgcctcagt ttccctcctt catggtaaac
       61 atctccccat tagccaaaaa gtctgtttta gggtcccagt cccatcaatt tctcctgatt
      121 aaaaaaatgc aggctggggc agggtgtagg gaggaggaga taaaggcagg ttagtgctgg
      181 cctgccttct gttcctaccc acacacaaac ttccatcaga aatacgtgtg tactaatatg
      241 ggtcagcagg acaattgtgg aaggcaaatg gatcacagtg gggcttttgg gtataactgg
      301 atctgtgtaa cttttgtctg tgggcacaca ttcatgggtg tgactttctg aggttacatg
      361 accaatgtat gactgtgaat gtgtggctat gggtatgagt gtaagtggct attaggagat
      421 gccacagtgg gtcatggctg tcctaagctt ctgtaacatc agacccctac accattccct
      481 agccctctcc catcttctct gttcagggct tagaaacctg tagagaaacc gcagttcggg
      541 aaggggatag ggtcacagaa acaggccaag attaggactc agtatcacaa gataagccag
      601 gcatcaccgc ctgtgtctga ctcacctcga gcccgaggca aagacagcta gataaaagct
      661 aggggagcca gagaaagaaa ggaaggaacc tccaggctga gcagcatgga ggggctctcc
      721 ctgacgggca gcctcccgct gatactgttg cttctgagcc cagttcctga agcagccttg
      781 ccactgccct ccagcactag ctgctgtact cagctctata ggcaaccact cccaaccaga
      841 ctactgagga ggatcgtccg tgtggagctg caggaggctg acggggactg ccacctccaa
      901 gctgttgtgc ttcacctgac tcggcgcagt gtctgtgttc atccccagaa ccgtagcctg
      961 gctcggtggt tagaacgcca tgggaaaagg ctccagggga ccctacccag tttaaatccg
     1021 gtactacaaa agaaaatgtg cccgagcccc caaaagcaaa agtaataaag caacattaga
     1081 cgataatctc caa
//
LOCUS       NM_001436943             643 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 11, mRNA.
ACCESSION   NM_001436943
VERSION     NM_001436943.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 643)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 643)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 643)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 643)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 643)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW528290.1, CR464309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000005.1  61741780-61741850   c
            72-139              JAXUCZ010000005.1  61741422-61741489   c
            140-199             JAXUCZ010000005.1  61741152-61741211   c
            200-643             JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..643
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..71
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     exon            72..139
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..356
                     /gene="Ccl27"
                     /note="isoform f is encoded by transcript variant 11; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform f"
                     /protein_id="NP_001423872.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSSAHPREQK
                     LEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQTAGALKI"
     exon            140..199
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            200..643
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccgtttc cggggcggag ccagggaggg cggggagttt aggctgtacc gacccctgag
       61 ccccccttca ggaaccgttc ggagctcgag acatgtcgcg attgaggaga tacgaggtgg
      121 cgctggaagc ggaggaggag atctactggg gctgcttcta cttttttcct tggctgcgaa
      181 tgtggcgcag ggagcggagc tcggcgcacc cccgggagca gaagctggag cctctgcggg
      241 gcctaatgag ctgtttgtcg agcggcctga ggcctgctcc ccagcgctca ggtcgcggtc
      301 tcctctgtcg cacccccacc gctgctgcac agacagccgg tgcattaaag atttaaagtc
      361 acgcccactg ccttcctgac tttaccgccg cagccgccac tggtgctggg aatcccactc
      421 cacacctgct gtttcttagc ccacagggca tccctccctg gtaggaagcc cttgcatgtc
      481 taagcctcca atgtccctaa aggtcaagct gccaattact atcagtgact ggctccctgc
      541 cacgccctcc ccaaaagcac ccacactgag agtgtaggcc acatctgtcc accacttccc
      601 agtattccca caacttcagc tattaccatc ttcctctagc cgt
//
LOCUS       NM_001436874            3166 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 2, mRNA.
ACCESSION   NM_001436874 XM_017600166
VERSION     NM_001436874.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3166)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3166)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3166)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017600166.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1703719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1831           JAXUCZ010000016.1  17498298-17498468
            1832-1955           JAXUCZ010000016.1  17503674-17503797
            1956-2006           JAXUCZ010000016.1  17504488-17504538
            2007-2143           JAXUCZ010000016.1  17505392-17505528
            2144-2204           JAXUCZ010000016.1  17508313-17508373
            2205-2287           JAXUCZ010000016.1  17509056-17509138
            2288-2420           JAXUCZ010000016.1  17518938-17519070
            2421-2626           JAXUCZ010000016.1  17531082-17531287
            2627-3166           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..3166
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3166
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2770
                     /gene="Eps15l1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 2"
                     /protein_id="NP_001423803.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMVKDDPFKNKALLFSNNSQELHPDPFQA
                     EDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKK
                     QTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSA
                     EGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGQS
                     TPVSQLGSSAFPESPDPFQPLEADSGDPFQNKKGFGDPFSGKDPFAPSSSAKPPKASS
                     SGFADFTSFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPA"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1828
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1828
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1831
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1955
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2006
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2143
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2204
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2287
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2420
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2626
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..3166
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggtaaa ggatgatcct ttcaaaaaca aagccttgtt
     1861 gtttagcaac aactctcaag agctgcatcc agaccccttc caggcagagg accccttcaa
     1921 gtctgaccca tttaaaggag ctgatccctt caaaggtgac cctttccaga gtgatccctt
     1981 ctcagagcag cagacagcag ttacagaccc atttggaggg gaccctttca aagaaagtga
     2041 cccattccat agctcaacca gtgatgactt cttcaagaaa cagacaaaga atgacccgtt
     2101 tacctcagac cccttcacaa agaacccttc cttaccttca aagctcgacc cattcgagtc
     2161 cagtgatccc ttctcatcct ccagcatctc ctcgaaaggt tcagatccct tcggaacact
     2221 agaccccttt ggaagcagct ccttcagcag tgccgagggt ttcgctgact tcagtcagat
     2281 gtccaagccc ccaccttctg gccccttctc ctcctccttg ggaggcacag gattctcaga
     2341 tgaccccttt aaaagtaaac aggacactcc tgctctgcct ccgaagaagc ccgctcctcc
     2401 acggcccaaa ccgcccagcg gtcagagtac acctgtaagc cagctgggtt cttcagcctt
     2461 ccctgaatcc cctgatccat tccagccact cgaggctgac agcggcgacc cgttccaaaa
     2521 taaaaagggg tttggggacc catttagtgg caaagatcca tttgcccctt cctcttcagc
     2581 taaacctcct aaggcctctt cttccggctt tgccgacttc acctcttttg gcaatgagga
     2641 gcagcagctg gcctgggcca aacgggagag tgagaaagcg gagcaggagc ggctggcgag
     2701 gcttcggcga caggaacagg aggacctgga gctggccatc gccctcagca aggccgatat
     2761 gccggcctag gtgacacagg ggaagccgca gctgtctgta tgtccacatc atgctcagag
     2821 cgtgccccct tcaagccaag ccatgccaca gccaaggaca gctggccaca gggcctcagg
     2881 ccacagggac cttgttgaga ggtagcagac acagcccacg cctgtgggtg ggccaggaag
     2941 gcagccttcg gtaaaaggcc tggaacctgc ctgtctctga ggtgtcagtc aggctcttcc
     3001 ttccaatcat tcagtgactg acggagaagg cctccagtct cctagctaca gacaagctcc
     3061 accccaaccc ttcctcacat ccacaagaca ccctgcacac atgatgtatg cattcgttgt
     3121 ataaaaatga agtttgaatg attaatataa aatattttaa tacaaa
//
LOCUS       NM_001436936             776 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 4, mRNA.
ACCESSION   NM_001436936
VERSION     NM_001436936.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 776)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 776)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 776)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 776)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1614177.1,
                                           SRR26360194.522045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000005.1  61741422-61741766   c
            346-405             JAXUCZ010000005.1  61741152-61741211   c
            406-458             JAXUCZ010000005.1  61738859-61738911   c
            459-591             JAXUCZ010000005.1  61737621-61737753   c
            592-776             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..776
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..345
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             299..748
                     /gene="Ccl27"
                     /note="isoform b is encoded by transcript variant 4; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform b"
                     /protein_id="NP_001423865.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERRLPLTGWHP
                     WNKTKEKQEALPLPSSTSCCTQLYRQPLPTRLLRRIVRVELQEADGDCHLQAVVLHLT
                     RRSVCVHPQNRSLARWLERHGKRLQGTLPSLNPVLQKKMCPSPQKQK"
     misc_feature    479..661
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    479..661
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            346..405
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..458
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            459..591
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            592..776
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaatc tccattcagg gcctaaacgt cccagctata ctgccgctag acccctctcc
       61 ttggtgactc cacgttccgg tccctagata gccatcctcc taacgcttta acttgtagtg
      121 atttccatat catccatccc atcctgtccc gatgtgacca ttggcttccg ggagggccac
      181 ctgcctcagt gtacctgagt attcagactt gtcctgggaa tgatggaaaa gggaacttgc
      241 aactgggaat aagtgttcct atcatgctgc tccccaggaa ccgttcggag ctcgagacat
      301 gtcgcgattg aggagatacg aggtggcgct ggaagcggag gaggagatct actggggctg
      361 cttctacttt tttccttggc tgcgaatgtg gcgcagggag cggaggctcc cgctgacagg
      421 ctggcatccg tggaacaaga ctaaggagaa gcaagaagcc ttgccactgc cctccagcac
      481 tagctgctgt actcagctct ataggcaacc actcccaacc agactactga ggaggatcgt
      541 ccgtgtggag ctgcaggagg ctgacgggga ctgccacctc caagctgttg tgcttcacct
      601 gactcggcgc agtgtctgtg ttcatcccca gaaccgtagc ctggctcggt ggttagaacg
      661 ccatgggaaa aggctccagg ggaccctacc cagtttaaat ccggtactac aaaagaaaat
      721 gtgcccgagc ccccaaaagc aaaagtaata aagcaacatt agacgataat ctccaa
//
LOCUS       NM_001436879            2821 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 6, mRNA.
ACCESSION   NM_001436879 XM_063275495
VERSION     NM_001436879.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275495.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.305029.1,
                                           SRR26360186.2885249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-2821           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2821
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2425
                     /gene="Eps15l1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 6"
                     /protein_id="NP_001423808.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPA"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2821
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 gtttggcaat gaggagcagc agctggcctg ggccaaacgg gagagtgaga aagcggagca
     2341 ggagcggctg gcgaggcttc ggcgacagga acaggaggac ctggagctgg ccatcgccct
     2401 cagcaaggcc gatatgccgg cctaggtgac acaggggaag ccgcagctgt ctgtatgtcc
     2461 acatcatgct cagagcgtgc ccccttcaag ccaagccatg ccacagccaa ggacagctgg
     2521 ccacagggcc tcaggccaca gggaccttgt tgagaggtag cagacacagc ccacgcctgt
     2581 gggtgggcca ggaaggcagc cttcggtaaa aggcctggaa cctgcctgtc tctgaggtgt
     2641 cagtcaggct cttccttcca atcattcagt gactgacgga gaaggcctcc agtctcctag
     2701 ctacagacaa gctccacccc aacccttcct cacatccaca agacaccctg cacacatgat
     2761 gtatgcattc gttgtataaa aatgaagttt gaatgattaa tataaaatat tttaatacaa
     2821 a
//
LOCUS       NM_001436942             635 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 10, mRNA.
ACCESSION   NM_001436942 XM_039110225
VERSION     NM_001436942.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 635)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 635)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 635)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 635)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 635)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 635)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 635)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 635)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 635)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110225.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1454908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000005.1  61741704-61741766   c
            64-131              JAXUCZ010000005.1  61741422-61741489   c
            132-191             JAXUCZ010000005.1  61741152-61741211   c
            192-635             JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..635
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..63
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            64..131
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..348
                     /gene="Ccl27"
                     /note="isoform f is encoded by transcript variant 10; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform f"
                     /protein_id="NP_001423871.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSSAHPREQK
                     LEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQTAGALKI"
     exon            132..191
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            192..635
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaatc tccattcagg gcctaaacgt cccagctata ctgccgctag acccctctcc
       61 ttggaaccgt tcggagctcg agacatgtcg cgattgagga gatacgaggt ggcgctggaa
      121 gcggaggagg agatctactg gggctgcttc tacttttttc cttggctgcg aatgtggcgc
      181 agggagcgga gctcggcgca cccccgggag cagaagctgg agcctctgcg gggcctaatg
      241 agctgtttgt cgagcggcct gaggcctgct ccccagcgct caggtcgcgg tctcctctgt
      301 cgcaccccca ccgctgctgc acagacagcc ggtgcattaa agatttaaag tcacgcccac
      361 tgccttcctg actttaccgc cgcagccgcc actggtgctg ggaatcccac tccacacctg
      421 ctgtttctta gcccacaggg catccctccc tggtaggaag cccttgcatg tctaagcctc
      481 caatgtccct aaaggtcaag ctgccaatta ctatcagtga ctggctccct gccacgccct
      541 ccccaaaagc acccacactg agagtgtagg ccacatctgt ccaccacttc ccagtattcc
      601 cacaacttca gctattacca tcttcctcta gccgt
//
LOCUS       NM_001436880            2954 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 7, mRNA.
ACCESSION   NM_001436880 XM_063275494
VERSION     NM_001436880.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275494.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.652970.1,
                                           SRR26643297.46656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-2414           JAXUCZ010000016.1  17518938-17519070
            2415-2954           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2954
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2425
                     /gene="Eps15l1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 7"
                     /protein_id="NP_001423809.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKPAPPRPKPPSVWQ"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2414
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2954
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 gcccccacct tctggcccct tctcctcctc cttgggaggc acaggattct cagatgaccc
     2341 ctttaaaagt aaacaggaca ctcctgctct gcctccgaag aagcccgctc ctccacggcc
     2401 caaaccgccc agcgtttggc aatgaggagc agcagctggc ctgggccaaa cgggagagtg
     2461 agaaagcgga gcaggagcgg ctggcgaggc ttcggcgaca ggaacaggag gacctggagc
     2521 tggccatcgc cctcagcaag gccgatatgc cggcctaggt gacacagggg aagccgcagc
     2581 tgtctgtatg tccacatcat gctcagagcg tgcccccttc aagccaagcc atgccacagc
     2641 caaggacagc tggccacagg gcctcaggcc acagggacct tgttgagagg tagcagacac
     2701 agcccacgcc tgtgggtggg ccaggaaggc agccttcggt aaaaggcctg gaacctgcct
     2761 gtctctgagg tgtcagtcag gctcttcctt ccaatcattc agtgactgac ggagaaggcc
     2821 tccagtctcc tagctacaga caagctccac cccaaccctt cctcacatcc acaagacacc
     2881 ctgcacacat gatgtatgca ttcgttgtat aaaaatgaag tttgaatgat taatataaaa
     2941 tattttaata caaa
//
LOCUS       NM_001012038            5730 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3),
            transcript variant 1, mRNA.
ACCESSION   NM_001012038 XM_223569
VERSION     NM_001012038.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5730)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 5730)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 5730)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 5730)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 5730)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 5730)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001012038.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  83684312-83684495   c
            185-233             JAXUCZ010000014.1  83628633-83628681   c
            234-323             JAXUCZ010000014.1  83611592-83611681   c
            324-440             JAXUCZ010000014.1  83611102-83611218   c
            441-523             JAXUCZ010000014.1  83604938-83605020   c
            524-690             JAXUCZ010000014.1  83602356-83602522   c
            691-787             JAXUCZ010000014.1  83592224-83592320   c
            788-901             JAXUCZ010000014.1  83588725-83588838   c
            902-1107            JAXUCZ010000014.1  83583226-83583431   c
            1108-1239           JAXUCZ010000014.1  83582300-83582431   c
            1240-1351           JAXUCZ010000014.1  83581721-83581832   c
            1352-1547           JAXUCZ010000014.1  83575932-83576127   c
            1548-1733           JAXUCZ010000014.1  83575039-83575224   c
            1734-1904           JAXUCZ010000014.1  83574230-83574400   c
            1905-2050           JAXUCZ010000014.1  83572847-83572992   c
            2051-3455           JAXUCZ010000014.1  83570317-83571721   c
            3456-3566           JAXUCZ010000014.1  83568961-83569071   c
            3567-3655           JAXUCZ010000014.1  83568438-83568526   c
            3656-5730           JAXUCZ010000014.1  83564065-83566139   c
FEATURES             Location/Qualifiers
     source          1..5730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5730
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..184
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..233
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Mtmr3"
                     /note="upstream in-frame stop codon"
     exon            234..323
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..3827
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 1"
                     /protein_id="NP_001012038.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEYVGRA
                     EDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQ
                     CQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNE
                     VERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVI
                     YRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRG
                     FPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEY
                     YPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAL
                     LVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGH
                     KFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCL
                     FGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
                     LWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNMVPLA
                     SRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAAGVAE
                     GQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQEPQLD
                     DATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVENIAE
                     DRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSESGPQ
                     LHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAPCALP
                     LDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLSA
                     TSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQRLRQI
                     ESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNCLSR
                     CSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCS
                     SCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN"
     misc_feature    252..254
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    297..578
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    297..578
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    735..1685
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    735..1685
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    1989..2069
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2067..2069
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    2127..2129
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    2169..2171
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    2181..2183
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    2319..2435
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2415..2417
                     /gene="Mtmr3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    2796..2855
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2868..2933
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2952..2954
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13615; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    3036..3155
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3204..3293
                     /gene="Mtmr3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5PQT2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3420..3422
                     /gene="Mtmr3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8K296; propagated from
                     UniProtKB/Swiss-Prot (Q5PQT2.1); phosphorylation site"
     misc_feature    3573..3755
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    3573..3755
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    order(3576..3578,3585..3587,3639..3656,3660..3665,
                     3735..3743)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     misc_feature    order(3576..3578,3585..3587,3639..3656,3660..3665,
                     3735..3743)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     exon            324..440
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..523
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..690
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..787
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..901
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1107
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1239
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1351
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1547
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1733
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1904
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2050
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..3455
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3566
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3655
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..5730
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccgc tgccgccatg ttgttgtggt tgtgagaagg cggcggcggc agcggtggcg
       61 gcggagcagc cggtggagac gctccagcgg cccaggcgct gccccccgcc gaccctggct
      121 ggcagcctcc tggggtggcg gaggaggccg tgcggtggcg ggcctcgcca tgtcctgcct
      181 cccgatttcc ttgtaaaacc ttgtagaaga aaaagttctc aggaagatac ttggatgaag
      241 agatgcggca tagccttgag tgcatccagg ccaatcagat ctttcccagg aagcagctga
      301 ttcgggagga tgaaaatctt caggttcctt tccttgaact ccatggagag agcacagagt
      361 atgtgggccg tgctgaggat gccatcattg ccctctctaa ttacagactt cacatcaagt
      421 ttaaggagtc tcttgtgaat gttccattac agcttataga aagcgttgaa tgccgtgata
      481 tatttcagct tcacttgaca tgcaaagact gcaaagttat caggtgtcag ttcccaacct
      541 ttgagcagtg tcaagattgg cttaagagat taaacaatgc aatccgacca cctggaaaaa
      601 tagaagatct cttctcattt gcataccatg cttggtgcat ggaggtctat gccagtgaaa
      661 aagagcagca tggagacctg tgcagaccag gggaacatgt aacgtcaagg tttaagaatg
      721 aagtggagcg gatgggtttt gatatgaaca atgcctggag gatttccaac atcaatgaga
      781 aatacaaatt atgtggtagt tatccacaag agctcatagt acctgcctgg atcactgaca
      841 aagaactaga aagcgtggca ggcttcagat cctggaagcg catccccgcc gtcatctaca
      901 ggcaccagag caatggagcc gtcattgccc gctgcggaca gcccgaggtt agctggtggg
      961 gctggcggaa tgctgatgat gaacatctgg tgcagtcagt ggccaaggct tgtgcttctg
     1021 actctcagtc aagtgttggc aaggtttcca ctcggaacag ttgtcggggc tttcccaatg
     1081 caggggatct ttctgatgtg gagttcgatg cctctctgtc aaatgcttca ggaacagaaa
     1141 gtttagctct ccagccacag aagcttttga tcttggacgc acgctcctat gcagcagctg
     1201 tggcaaatcg agccaaagga gggggctgtg agtgtccaga gtattatcca aactgtgaag
     1261 ttgtgtttat gggaatggca aacatacatt ctatccggag gagtttccag tctctgcgac
     1321 tgctgtgcac acagatgcca gatcctggaa attggctttc tgctcttgaa agtacgaagt
     1381 ggctccacca cctgtctgtg cttctgaagt cggcacttct cgtggtgcat gctgtggacc
     1441 gagatcagcg accagtgctg gtgcactgct cagatggctg ggatcgcact ccccaaatcg
     1501 tggccctggc taagcttctg ctggaccctt attaccgaac cgtagagggt ttccaagtcc
     1561 ttgtggagat ggaatggctg gattttggcc ataagtttgc tgatcggtgt ggtcatgggg
     1621 agaactcaga tgacctgaat gagcgttgcc cagtgtttct ccaatggctt gactgtgttc
     1681 atcaactcca gaggcaattt ccttgctctt ttgagttcaa cgaagcattc cttgtgaagc
     1741 tggttcagca cacctattcc tgtctctttg ggacattcct gtgcaacaac gccaaggaga
     1801 ggggggagaa gcagactcag gaacggacat gctcggtgtg gtcgcttctg cgggccggca
     1861 acaaggcctt caaaaacctg ctatattcat cccagtcaga agccgtgctg taccctgtgt
     1921 gccatgtgcg gaatctgatg ctgtggagtg cagtgtacct tccctgcccg tccccatcca
     1981 cccccacaga cgacagctgt gcaccatacc cagccccagg caccagccct gatgagcctc
     2041 cactgagccg gctacccaag actagatcat ttgacaatct gaccacaacc tgtgacaaca
     2101 tggtgccgct ggccagccgg cgcagcagtg accccagcct gaatgagaag tggcaggagc
     2161 acgggcgctc gctggagttg agcagctttg ctggctctgg ggaagaggtg cctgccatag
     2221 acagcctgcg caggcccagc aggctgctcg gaggagccga gctatctgtg gcagctggtg
     2281 tggctgaagg gcagatggag aatattttgc aagaggccac caaagaggag agtggggtag
     2341 aagagcccac ccacagggag cacactgagg tgccagaggt caaagaggag gcacccctag
     2401 caaaagagag taggacggca gctcagggct caggtgtact ttaccaagaa ccacagctgg
     2461 atgatgctac tctaaggagc catttaggcc ccagcctgtc ttcgttctcc cagggtattc
     2521 ctgagcatcg ggaggtgggg cacagtgttc tctctagttc actcccagct tctctcaggg
     2581 gagaggactc ccaggaggtc cctgtagaac agcctcaagt agagaacatt gcagaggaca
     2641 gggagaatgt agtccctgct gtcccagtag atgtaaaaat tggccttggt acctcagagt
     2701 ctagtcctct gctgccttcc caagtcccat tcgagacaag aggaccacac atgaacaact
     2761 ccgtgcacat gttattagaa gataaggtga agtccgagag tgggccccag ctccatcaca
     2821 gaccctgcct ggcaagcagt ggtagattca gtggcaagga catgcttcct atagcaccag
     2881 agcccaggtc tgctgagagg ccccagtggg actctgtgct acacaggact tcttcccctg
     2941 gcaacaccct cagcctgatg atgcaggctc cttgtgcctt gccattagac aaatgtagac
     3001 agagaattgt gtgcaacggt gccctagaga ctgaaaacaa ggcctcagaa cagcctgcag
     3061 ggtttgacac ccttcagaag taccccacac ccaatgggca ttgtgccaat ggggagactg
     3121 ggaggagtaa ggactcactg agccaccagc tgtctgccac aagctatagc tctgctcact
     3181 cgtgctcaag gaacttgcac cacaagtggc tgaatagcca ctcggggagg ccatccacta
     3241 ccaacagccc tgagcagcct tcccgcagcc acctggatga tgacggcatg cctgtgtaca
     3301 cagacacgat ccaacagcgc ctgcgacaga tagagtctgg tcaccagcag gaagtggaga
     3361 ccttgaagaa acaagtccag gaactgaaga gtcgcctgga gagccagtac ctgaccagct
     3421 ctctgcgctt caatggggac tttggagatg aagtgacttc aatccccgac tcggaaagca
     3481 atctggatca gaactgtttg tctcgctgca gcacagagat tttctctgaa gccagctggg
     3541 agcaggtgga taaacaggac acagagatga cccgttggct acctgaccac ttggctgccc
     3601 actgctatgc ctgtgacagt gccttctggc ttgccagtag gaagcaccac tgcaggaatt
     3661 gtgggaacgt attctgctcc agttgttgta accagaaggt tccagttccc agccagcagc
     3721 tctttgaacc cagtcgagtg tgcaagtctt gctatagcag cctccatccc acaagctcca
     3781 gcattgacct tgaactggat aagcctattg ctgccacttc aaactgaagc tcagtgacct
     3841 ggggtgacag aggccatgct gctgtccctg taacaggctc acacacagcc tgggcagtcc
     3901 gagaagccca tacattttgg atgggggcat ggaacaacct gtacagagat tggggtgtac
     3961 cactggatcg tagatcgatt ttcctttcct tccccttccc tttccatcct cctctttgcc
     4021 ttctaaaaag aaaaatgtcc cagttgtctt aatttttttt aatggaagcc cagaggttac
     4081 caggctctta gaactgctga gtggcttgct gtcgggcact ctgtgacatc actcagtgct
     4141 tccctatgga aggaggcaca atgaaggcct gagacagcag gacagaaagc cagcctacca
     4201 ttaatgaccg ttctccacat gaagctgtgc cacagttgac tggtgcacct ttgcagctgg
     4261 ggaggctgga agcccttttc ttgagtactg ttcctcagag ggatagatag ggccatccta
     4321 cctcacagac aaaaagcagg atggtgttga gaggaagcac acagtgaagt gctccacagg
     4381 cctcactttg aaaagagagg tatgtgcttc ttttgagtta ctgagggcct agatggctga
     4441 catgttggcc caggtggatc catctttaac aagattgggt agggctttct ttgcttcttt
     4501 aggcttccag accaaaaggt acagactggc cagaaagcag tatcctgctg cagtggtcaa
     4561 ggcctgcact gagctgggca cctgaggtcc ccctctgggt cctagtccca taagcaatct
     4621 cttcctcagc caacacaggg aaatccagac tcagggttcc acagtctcct gttcccaaag
     4681 caaaccaatc atgcatctcc ccttgaggga cagatcccca cagttccgaa gctctccaca
     4741 caatcagcct tcctctctta cttctgggca gcaggaagga cccaggagtc ccttgtcctg
     4801 cttttggctg cctgagtggg cacatgtctg gctcttgcta tcagtgaaga gcccttggtg
     4861 attgtagggt tcttagaaga tgacatggct gaggagattc ggggtacctt cccgtagtga
     4921 gctttgatgt ggtccaaaaa gagccttaag tctgtagtta tctgtgctgg aggtgggtat
     4981 gaagggtaga gagcagtttt ggtttgtact ttgaattgtt ggcatctgtc tgtgcccacc
     5041 ccatccccca agggtgatgc ttggctctgc caaaagctgc aatctggtaa cagagcagat
     5101 tatagtgttg gggctgggtg aggctgggtg aggctggggg acacctaatt ttagcctggc
     5161 ctatgtcctt gctcctctcc tctggaagct gttacctggc catgggcctt ccgtgtctca
     5221 ggaaggtggc ttctgcatgt tcctcagtat gactggagaa gccagagcct tcccagcagt
     5281 tgtgtgctga agggaaggct gcagtctccg agtattgctg gtccttcagg agcaggccgg
     5341 gcagaggccg agtttagtga aacagggtga agttctccaa gctcgctgtg gtctggagtt
     5401 gcgggtgggg aaggtcggca taactgaaga ctgcagttcc tagtgagagg tgccaagagg
     5461 ttatgatacg ggtgtcttgg gtctgttgta cagtgtgaat aagtgcttgc agctcttagc
     5521 cctttttgat caatgaagca cttttttatt aatattttct ttgtatgtaa aggaggaacc
     5581 gtaactctcc atagctgtac atataacccc tttctcctaa agaggagtcc gtgctcctat
     5641 atttttcatt ttttgtcaaa gcaagaagta aatactttag aattgttaaa tacatagata
     5701 aagtgaataa agttgagtgt cagcaaggtg
//
LOCUS       NM_001436877            3025 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus splA/ryanodine receptor domain and SOCS box
            containing 1 (Spsb1), transcript variant 2, mRNA.
ACCESSION   NM_001436877
VERSION     NM_001436877.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Nishiya,T., Matsumoto,K., Maekawa,S., Kajita,E., Horinouchi,T.,
            Fujimuro,M., Ogasawara,K., Uehara,T. and Miwa,S.
  TITLE     Regulation of inducible nitric-oxide synthase by the SPRY domain-
            and SOCS box-containing proteins
  JOURNAL   J Biol Chem 286 (11), 9009-9019 (2011)
   PUBMED   21199876
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.21509.1,
                                           SRR26360176.2055833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000005.1  165666989-165667199 c
            212-1053            JAXUCZ010000005.1  165650886-165651727 c
            1054-3025           JAXUCZ010000005.1  165641255-165643226 c
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3025
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
     exon            1..211
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     exon            212..1053
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    336..338
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="upstream in-frame stop codon"
     CDS             360..1181
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 1"
                     /protein_id="NP_001423806.1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
                     /translation="MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMP
                     PVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQI
                     TWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKT
                     YPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWG
                     HCEIRMRYVNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ"
     misc_feature    519..1040
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    519..1040
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    order(588..590,594..596,690..692,744..746,1005..1013)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    order(588..590,594..596,690..692,744..746,1005..1013)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    1053..1178
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    1053..1178
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    order(1056..1073,1089..1091,1119..1121,1137..1139)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     misc_feature    order(1056..1073,1089..1091,1119..1121,1137..1139)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     exon            1054..3025
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccggcca ggactgatcc acgcagctca ggcacggcag gcctggggac ctgtgtgaca
       61 gccacattca ggactatacc cagatctcag cagcccggtg ctttcactgt gctccaaatc
      121 ctacccccct ggtggtgaag acccaccaac tttcctcctg gcttttctcc aaggcacttg
      181 cctggaacat tccagaactc tggattttgt ggcaatacag agcgcttcac aacctttgga
      241 aatcgcctag caacctccct taggggttct gtgtggccct gactagaaat ctggaatcaa
      301 cgccccaaga ttgatgagtt tgccttggga gtcagtgaaa aggtgaaaga aaggccaaca
      361 tgggtcaaaa ggtgacggga gggatcaaga ctgtggacat gcgggacccc acataccgac
      421 ctctaaagca ggagctccag ggtttggatt attgcaagcc cacccggctg gacctgctgc
      481 tcgacatgcc ccccgtgtcc tacgatgtcc agctgctcca ctcctggaac aacaatgacc
      541 gttcgctcaa cgtctttgtg aaggaagatg acaagttgat ctttcaccgg catccggtgg
      601 cccagagcac ggacgccatc aggggcaaag ttgggtacac acgtggacta cacgtatggc
      661 agatcacatg ggccatgagg caacgaggca cgcatgccgt ggtgggggtg gccacagcag
      721 acgccccttt gcattctgtt gggtacacaa cccttgtagg aaataaccat gaatcctggg
      781 gctgggacct ggggcgtaac cgtctctacc acgacggcaa gaaccagcca agtaaaacat
      841 acccagcctt cctggagcca gatgagactt tcattgtccc agactccttc cttgtggccc
      901 tggacatgga tgatgggacc ttgagtttca tcgtggatgg acagtacatg ggagtggctt
      961 tccggggact caagggtaaa aagctgtatc ctgtagtgag tgccgtctgg ggccactgtg
     1021 agatccgcat gcgctacgtg aacggacttg atcctgagcc cctgccactc atggacctgt
     1081 gccggcgttc ggtgcgccta gcgctaggaa aggaacgtct gggtgccatc cccgctctgc
     1141 cgctacctgc ctccctcaaa gcctacctcc tctaccagtg atccgcatcc caggatcgcc
     1201 gtatgacagc cacctggtgc caactcactg agcctttggg gtccaccgac ccctgcgcct
     1261 gggatggacg cccaccctca ggcatgggca gacgtaccct ctcatcccac cagctgcctc
     1321 tgctgggtgg accaatgcca acggacttct cccttcccaa cactggctga agcagcagca
     1381 tccaggccct tccctgaacc agatgcagag aataaactat gagaacctct ctcaggcgcc
     1441 tctgctctcc agtggagtgg gctgcccccc cactactccc tgaagagaga gtctacagcc
     1501 acctgggggg gttcctggga ggtgagacga gtgggagatg ccggggcaga tcccaaaagc
     1561 aggaatatgc aggaccaggc cacaccgatg aagctcagga tgtcacatac catggacact
     1621 gagacagaac cccaggctgg acctccctcg ggccagctct agtgtcagct gccggtgctc
     1681 cgtgccctgt atttattctt taaacagtag caaaggccgt ttatttattc cactgagaaa
     1741 ggaaaccttg ttgggtggct tccctcgatg tgctctgttg ctttcccccc acctgccacc
     1801 tccctggaat gtgtgtgcca cacccgtcct tctcctgggg ccaggcctgt ggcacgtgag
     1861 ctggtgtgca cagatacaag tatgtcattg tgtacgacct ttgaccccgt tcccaagtag
     1921 ctctgcgcca agcaccagag cagaacctga gtccccaggt acctgctcct gttacctgga
     1981 gcgtccatac accatcacac gtgttttgat ctctcgtctt ccgtgtgctt tgaattttgc
     2041 ccccccccaa tttttctgat atttcctgtt gaatcctcca aagttctaga cctggaggac
     2101 catcgggaca ccgggggtga ggggaggggt ctccagcccc tgggaaagcc acaggcaagg
     2161 caggattaga ccttgtctca cacacacacc ctcaagcctc agcagtggct gtagggtgga
     2221 caggacgggt gcctgtctcc tgcagcacac caatggagca ccactgctcc ggctctctgg
     2281 gcatgtggtc ggttgggaga gggcttgcct agcacgcagg aagctcaggt tccatcccct
     2341 gcaccaagga gaatcaaagc tcaggaggct gaggcagggg gattgctgtt cagtgctgta
     2401 cagaggtcgt ggacatcccg ggctgtatta aatcttgtcc tttaagaaaa aaagaaaaga
     2461 aaccaacttc catcgaatct gagttctgtt catttctgca caggtacagt agatgacttt
     2521 atttgttgaa aatgtttaat atatttacat agatatattt gtaagaatca ttttaagcag
     2581 ctgctgtagg gtaccttttt taaaaaataa ataaacatct tccagtagag tataattttt
     2641 aaggcacaga ggtggtgccg agactagata aagaatctaa gtcattccct ctgcgttttg
     2701 aggtccttct ccttttttgg gaggggggcc ttttgtcaga cagaaatctt actcgttctg
     2761 gttttggagc ggatcacatt cagccgcata gatcccagct tgatctccac ccggccgtac
     2821 cctcacggat gctggcgaac agcaaggctc tcctgtgtcc cccatactcc gccgccccag
     2881 gactcaccac acctccctgc cgtcccggca ccatcaccgt aaagccttgt ggcatgtata
     2941 gttctgaaat ccccgttctg ttctgtttta tgatgactca tatcagtcag taacctaata
     3001 aaggaaagtt tgttaaaata tgaaa
//
LOCUS       NM_001107314            9220 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 3, mRNA.
ACCESSION   NM_001107314 XM_001066385 XM_224905
VERSION     NM_001107314.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9220)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001107314.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643429.50752.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000016.1  62495181-62495479   c
            300-524             JAXUCZ010000016.1  62494663-62494887   c
            525-713             JAXUCZ010000016.1  62470460-62470648   c
            714-868             JAXUCZ010000016.1  62460835-62460989   c
            869-1042            JAXUCZ010000016.1  62453208-62453381   c
            1043-9220           JAXUCZ010000016.1  62439625-62447802   c
FEATURES             Location/Qualifiers
     source          1..9220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..9220
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..299
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            300..524
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            525..713
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    706..708
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="upstream in-frame stop codon"
     exon            714..868
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     CDS             715..2055
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /codon_start=1
                     /product="probable tRNA methyltransferase 9B"
                     /protein_id="NP_001100784.1"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
                     /translation="MDPEAVQLEKQHVHKVYESTAPYFSDLQNKAWPRVRQFLQDQKP
                     GSLIADIGCGTGKYLKVNSQVHTLGCDYCGPLVEIARNRGCEVMVCDNLNLPFRDQGF
                     DAIISIGVIHHFSTKQRRIRAIKEMARVLAPGGQLMIYVWAMEQKNRHFEKQDVLVPW
                     NRALCSRLLSESHQSWGHSCEHPTSQGYQGPGSACSCAVCFKGRCDSKRSHSMDYGPA
                     VARTCCEAISKEGQQENGLYSNFGKSFRSWFFSRSLDESTLRKQIERVRPMKIEGWAN
                     STVSHQPSRYPSVDLHAQEPFSTKRPNLDEVFVDASSQRHVGCLGVPSTSDNFIGHKG
                     GESRRKEGGNFLDTTDTGNSVAARNGGDRSARKILRRVSAFDSTDSTSEDPSFVEGQQ
                     DGPDSKAFMRYYHVFREGELSSLLQECVSELQVLSSGNDHGNWCIIAEKKRSWD"
     misc_feature    802..1143
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     misc_feature    802..1143
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     exon            869..1042
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..9220
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggtgagaga caggaaggtc atcctgattc
      181 cagcctcagg cacgtccggg cgcggcgatc gcaggggaca gacagagcgg ccacaccgct
      241 tgggctctgc cgcgcgcccg cgccgcaccg agccgactcc gaggcgcccc gggcttgcgg
      301 ccgacccatg gaagttgcat cctggacagt ccgggctgcg acgctgaaga gcaccgagcc
      361 agtgctcggc cgagcctccc gcccggatcc cgggcaaaga ccgcccaaaa cctgctgttg
      421 accttcgtct gcactgctca atggtgaccc gagtcttcgc tgtcctagtt gcagccattt
      481 ggcatcccca agactgccag agcacccggg atctgcaaac ctggggcttg gattctcttc
      541 agagactcat actgagtggt ggatcttgtg aagggctcac taactcaatt cctgctcctt
      601 tcatgtgtgt tatatactga gagccctgag aaggaactgt tcctccctga ggaaggaaac
      661 tgccgtgatt taccaaaacc agaaataatc cacatgatca caaaatgagt caggatggat
      721 cccgaagccg tgcagctgga gaagcagcac gtgcacaagg tctatgagag caccgccccc
      781 tacttcagtg accttcaaaa caaagcttgg ccccgcgtcc gccagttcct gcaggaccag
      841 aagccaggca gcctcatcgc tgacattggt tgtggaactg gaaagtatct taaagtgaat
      901 agccaagtac atactctggg ctgtgactac tgtggccctc tggtagagat tgcccggaat
      961 agagggtgtg aagtcatggt atgtgacaac cttaatctcc cctttaggga ccagggcttc
     1021 gatgctatca tctccatagg agtcatacat catttctcta caaaacagag aagaatcaga
     1081 gcaataaagg aaatggccag ggtcttagct cccggaggcc agctgatgat ttacgtctgg
     1141 gcaatggaac agaagaaccg acactttgag aaacaggatg tgcttgtgcc atggaacagg
     1201 gcactctgtt cccggctgct gtcagaatcc caccagtcgt gggggcattc gtgtgagcat
     1261 cccacgagcc aaggctacca gggccctggc tccgcgtgca gctgtgcagt gtgttttaag
     1321 ggcagatgtg attccaagcg gtcgcacagc atggactacg ggcctgcggt ggccagaacc
     1381 tgctgcgaag ctatttcgaa ggaaggacag caagagaatg gattatatag caattttgga
     1441 aaatcctttc gctcctggtt tttttccagg tctttggatg aatcaaccct gaggaagcaa
     1501 attgaaaggg tcaggccgat gaaaatcgag ggctgggcca acagcaccgt gtcccaccag
     1561 ccttcccgat accccagcgt agacttgcat gcccaggagc cgttttcaac aaaaagaccg
     1621 aacttagatg aggtgttcgt agacgcatct tctcaaagac acgtgggctg cctgggagta
     1681 cccagcactt cagacaactt cattggacac aagggaggag agagtaggag gaaggagggg
     1741 ggcaattttc tggacaccac tgataccggg aacagtgtgg ctgcaagaaa tggcggtgat
     1801 cgttctgcca gaaaaatatt aaggagggtt tctgcattcg actccacgga ctccacctca
     1861 gaagacccaa gctttgtgga agggcaacag gatggcccag attccaaagc cttcatgcgt
     1921 tactaccacg tgttccggga aggtgagctg tccagcctgc tgcaggagtg tgtgtctgag
     1981 ctgcaggttc tgagctccgg caatgaccat ggtaactggt gcatcatcgc agagaaaaag
     2041 aggagctggg attaactaca tcgctcaagg cagaggctac agcccatcat ctgctcaatg
     2101 gggctgatgt ggacaccaga atcggcaccc tagttcattg ctttcaaatc caggtatgag
     2161 tcggaccgtg agcactgtgc cctcatcctc cgaactgttg agtaagcatg aaggctggca
     2221 tgtcctgcct ctgctgcggg atctgcctgc tgaagtttca atcaaaggat ccgaggaagc
     2281 agtagaaagt aaacttaagt acagacttga tcttattcct cccagagatg aaattattac
     2341 gatacgtgta cgtcaagtgt cagtattatc ttttggtttt taaataatcc cctgttaaat
     2401 atacctttta aaagtagtaa tttttaaaaa taaattatgt tggttctcag gtagttactt
     2461 agatccctgt ggaaggtaac agagacacct gtgctgttgc tgggcatgtg tttaaggttc
     2521 gctgtggtgg tatctcgttt ccggacttcg ttgctaacta catcaaccct tccagtatag
     2581 cccagaccct ctaaattaca tgcaaacgcc cttagggatg atcgatgtta ctaatactgt
     2641 cttcagcatt gctctgaggc ttttacaagg cgctattagc agagggttgg tgttaaagca
     2701 gacagtttgc atgcggcgga atcagcaaac atccatggca ccattgacag aagaaaaagt
     2761 aaacaaagga ttgttagcgt gcagagtgct ttacaggggt agcagatggt atgtcccctg
     2821 gtcacatttt ccccaaaggc attaggagca taaatatcta actgaggttg tcccaaagtt
     2881 atccagagtt ttcaactagg aagtgcatat ctgagttagc taagagtcta attggagccg
     2941 ttttactttg gctgtgagga cagatctgga aatcgtcatg tatttagtgg acacattact
     3001 gggattcgct gctgcatgcc atggcattta ttcccttgaa ggtgaccaca ttagatcatt
     3061 gtatcagtga cctggacgga atcaaagctt ggtcacaagt tgaatttctg gtattctaga
     3121 gtgcaatgat tagactgggt atggtacaaa tcaatactct tttattttta aagacttaat
     3181 catgagtctg attaattcta tgttgtggat cccaataaca attatgacag aattcaagac
     3241 tgaactcagg agaaacaaaa ataagttggc caaggaatat ggttccagat aattcgttaa
     3301 caagcaggaa atcaaatagt cattgtactt tctggaccga tataatgatg gagattggat
     3361 taaaatccaa tcttcacttt ctttttttct cccactacaa agttaacaaa aattgcaatg
     3421 gatcatattt atttggtgtt taccctcttc agagattttg ctggactgta tgaaaatgaa
     3481 gctacttttg aaaaacacaa ctcaaaaggt gctttgaaaa tgcaaagtat atcttgtaaa
     3541 ctttagaatg aatcagataa ttcctgaggt tctttcaagt ccaagttccg tctcttcaac
     3601 cctgctgtgg aagtggcatg tgtgtcttgt actttccagc gtacactttg tacagggagg
     3661 catgaaaata ggcatagggg taaagcatag attaaaattt actgtgcctt ccacttcttc
     3721 aaatgaagat attaaactcc atgtacggtg gcttcctggg agaagcggtg actctgaact
     3781 agtcagcagt aatgacctct ttattatggt ttcccgcttc tctgaggtct gtgtcacttt
     3841 gacttggctt tcgctgctgg atgtctaagc ctgacatcac cctggttgga atgtgctacc
     3901 taaaggtcat tctatggaac tcagttcatc aggctgtgac aggatggttt accagctgat
     3961 atgtctgaac aagctcacaa aataaacaca caccccatct tgtattaaaa agccttcgga
     4021 atggttattg ggatagagag agatttttcc tacaatgata gagctgtgag cgctaataac
     4081 accaaccttg ttaagtgcaa gaattccatg catccagatg ttttattgtc tatttagcaa
     4141 aatctgtggc tggtaagctt cctgggatcc ttgtgcaaaa gcagtcttcc attcagtgtt
     4201 tgccttttga tgataaaaag ccattgagaa ctagtgtaaa tatcttaacc gtttaaaagg
     4261 ttgttctcct ttgggattgt cctcagaagg aaacacaagt cctaaatgta tataaatgga
     4321 gacggtgtat gtccgtcggc cttaatcagc ttgtgggtgg atctcactga tctgtctaaa
     4381 gtgatggaaa aaaccttctc cacgttaaga caaaatggtg tttttctaat tccctcctgg
     4441 catccacaca tgagtcccac tgtctgacgg agggaaagtt cagggaagtc attagataat
     4501 tgttagaggt tggactagca gtacctcccc ggcttgtgtg gggcactttg tggaaacaga
     4561 caagtgattt ggggggaaaa gtgattgact tgaacgaaag atgcaatcaa agtaacagtt
     4621 tcctgggagg cgagtgattg gcaagcttct ctggttattg ggttttagtg ttcatgtggg
     4681 ggtggggggg tgttctttgt tggcagagag acgaagtatg accagagtgc tgcagtgctt
     4741 caggctggct atgcacacac actggctgcc atgctgattg atcctttcct ctaaccttgc
     4801 tgtacgccat ccccatactg tctgtcactc attttgccta cccctcatcc tgattctgga
     4861 ggccaaagac tcccatgtgc tcaactgacc ttcatttgag tcagcaaaaa aacaaaaaaa
     4921 caaaaaacaa aacaaaaaaa aaaacaaaaa acaaaacaaa aaaacaaaaa aaaactgaag
     4981 gtgattcagg tgggaaagga tccaaatgta aatcaggatt tcaaaagtac ttgactacta
     5041 ttggccatgg aacaaatgaa tgctggtaga tctttcaaat acgtgggctc ccaggagaac
     5101 aggaaatggg accctagttg tactcattat gtgagtgaat gccttagaaa caaggtgtga
     5161 gggcctactg ggtggcttgc tggtttagag tgctgtcctg cagatggcct gaaagtggct
     5221 cctagcacca tgtcagacag ctcacaagtg cctcttcagg atgccgaggg tacctgcact
     5281 ctcgtgtgca cagacctaag catacatgca cagacacaga cacagacaca cacacacaca
     5341 cacacacaca cacacacaca catacacaga cacatgcaca cacagacaga cacagacaca
     5401 cacacagaca catacacaga cacacacaca cacaggcaca cacacaggca cacacacaga
     5461 cacacacaca ggcacaaaca cacagacaga cagacacaca gacagacaga cagacacaca
     5521 gacacacaca cacacacaca cacacacaca ccaaaaataa atatttttta agaacaggct
     5581 atgcatgccc agcctgaatg aggaaactga agtaactgtt cactacttgg ttcttcagag
     5641 cctgttgtga tggtgcagaa aaaagtaagc caagtctcac ttttcctgaa cagaagaagg
     5701 gatgggtaac aatagcagct gactaatatt tatcacgtta tgtgtgtaac ccccaatagc
     5761 tgtctcaaac aaatataatc cccaatttgc agataagaaa ggcagaaaag gaaaaagata
     5821 ataatgcgct aagatatcag aatctacaca agcagtaaac atcacccatt tagtgaaaaa
     5881 cagctaagat tcagtcctag actgtctgga tccggtctaa gttcataacc acctgccagg
     5941 tcccagactc tatgccaagt aagcaacaga gtgtgcaagg ttaagtgtga ctgtcccctg
     6001 cacaaatgca ttaagcaggt taggaaaaga ctacacctct ctttcccctt cgtgctgtct
     6061 tttcagtatt tcacatgtac ttgtctgtgc atctgtccct gaggaggtcg gaagatagct
     6121 tgcaagagtt agttcattcc tctaagatct atatgtcccc tgagccctct tgccagccct
     6181 gttttgtttc tttgtttgtt ttataattct atttctattt gactagaatt taaaaagctc
     6241 ttgatcacag ggcactctga tcactttcta caattcccaa accctccaaa aagcatagct
     6301 ctgttttcct gttttaatca atgaagaact tagggactaa cacaggtatt cctttttttt
     6361 tttttttttt tgttcagaac cgtttggtgt ctctagatac aagtgatgaa agccaggaca
     6421 tatctggggt attgggttat acacaatatg aagacttaat gaccaaaaat tcaagtgtcc
     6481 tgctggaaca cattttgttt ttgctgtatg tctgtgatca catgacattg ttagttttgt
     6541 aaaacacaat attcaaaccc ccttcctggg gtgggggaag agaggatcac gatgcatata
     6601 attaacatgg agaatgcctg tctgacacac ttagatttca tttaactgag gctaccctgg
     6661 gccaattgac acagcctcca gcacaagtgc tcagtaaacg tatttcagaa aaggatgtgt
     6721 cctgtaggga cagatatgaa gtcattcgga aggcatgcag gcccctagta accaactcaa
     6781 gttctgtttc agactcgttt cctacaattg cacctgtttt ctgttctgca atcagctatt
     6841 ttaaacaatg atttcattaa aactacataa tagcaagtca ttatcccatc ccttgaaggg
     6901 atctaatata ttcagactag aaatgctgtt aattataaac tttcctcaaa gacagacgca
     6961 ccagcaggct cattccatca atagacacag gaatgctagc actcatctgg caaagggagc
     7021 cctgggaaag tgagaggatc agaagcccca cttgatattt caagtcctct ggtcccagcc
     7081 ttgggtcaga aaccagaact ctgttttgac accatggact ccatccccaa gtctccagtt
     7141 atattcaaaa ctggggtaag aacttaaaaa aaaaaaaaag ctcttagcaa ccaagaactg
     7201 agatcaaagc acaaatagca ttccaaggga gggaagactg gaaacccaag agaatgatga
     7261 aacaaaacgc aggctatgaa gtgtacagtt tttcatcttg tttgaaacag ggtctcatgt
     7321 atcctaaact ggccctgaac ttgctgtgta cttgaggata accttaactt ctgatcctcc
     7381 tggtttctat gagacaggag atccagtgca aggcctgatg cataataggc aggaactcaa
     7441 cccattgagc ctcatctcca gccccaagct gtgtaacgca ttattcaccc tgagtcccac
     7501 agtgtacccc agtagtagaa gtgtttcatt ggagtgttac cctactgtct gcccctccac
     7561 tatgacggtt ctccttcgat ggattataaa cagacaatag atcacttcat gttgctacgt
     7621 aatctggcta atccaatgga ccacttgtga gaactgatat ccgatcagat actcaactgg
     7681 caaatacacg ctttgtctcc tttcgactag agctgggaaa aaaataaagc agactctagt
     7741 ataattaagt gttaattcaa ccacatgaaa acacctgatt ttctccttag ttatttgtcg
     7801 aaggctccta tctcatgggg gaaagtgagt gccttagttt cggttttatt gctgtgacca
     7861 tggcaactct tgtaaatgta aacatttgat gagggctggc ttacagtttc aaaggtccat
     7921 tatcatcata gcaggaagca tggcagcagg catggtgctg gaagagccaa gagttctaca
     7981 tcttggtctg caggtagcag aaggagactg gcctccacag gcagtcagga ggaggctctg
     8041 attccacact ggatgtagtt tgagctttta tatgagaccg gaaagcctgc ccccacagtg
     8101 acacacttcc ttcaacaagg ccacacctcc taatagtatc cctccctgtg ggccaagcat
     8161 tcaaacacat gaatctatgt cagtcaaacc tattccaacc agcacggtga gtcatggtaa
     8221 ttcctttatg gcaagtgtag ccagatatca aaagtcctta gacgaagtat ccacaaattt
     8281 gcattcatac aggagaaaaa ctatgaaaca caagcttcct cttatgcact aatcctaaaa
     8341 cttctcctta gatggtgtat ggtaagaact caaaattctc ctgtttgttt atccaggaca
     8401 ttggcaatat ttaagaccca catgtaagat ctaagacatt ctgaatatgt atgtgaacat
     8461 gtcccatgtt cttcagatgc tcttcaatat gtatgtatgt aatatatatg tgcatacgca
     8521 tatttgtaga ctcccagtgt ttgttgtcat tactgaccag gaaaagagtt ctcttgtgtg
     8581 cttgcagaag acattaaatt agcaattacc ataggaacgc atctcattga attggccttt
     8641 attgttgctt caggagcatt taagaagact gctagatgct ttcatgcctt ccctggtgtt
     8701 gacatatgta tttgtgtcaa aagtgtgaag cttttttccc cttaaatata gttattttaa
     8761 tctccccccc ccagggggaa ctagcaatag atctagagca caaattgatg taagacatct
     8821 tgactcttac aataacctaa agatatttat ttacgtgaac caacagtggc caggatcttt
     8881 ttgtaacagc tatttaaaat agcataattt gtatgcctgt gatatgtagt tgattattta
     8941 tgtgtttgtg tattctttaa taatagtctc aaacaaacag gattggagtt ttcttcctcc
     9001 cgaatgtgtc agggcaggtg ctgttaggct cgctcacatg atgcttgtta cacttcaatg
     9061 aaactcaacc agtctgtact tgaattctgt tcccgttgtc tggaagctgg gttagccgtc
     9121 taatgataca gcatctttta tgggttgata gaaaggatat tatctacttt ttaaaagaca
     9181 tattttaaga ctaataaaag acgtagtaga ccaccccaaa
//
LOCUS       NM_019249               7604 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, F
            (Ptprf), transcript variant 3, mRNA.
ACCESSION   NM_019249 XM_039110163 XM_346987
VERSION     NM_019249.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7604)
  AUTHORS   Dyck,S., Kataria,H., Akbari-Kelachayeh,K., Silver,J. and
            Karimi-Abdolrezaee,S.
  TITLE     LAR and PTPsigma receptors are negative regulators of
            oligodendrogenesis and oligodendrocyte integrity in spinal cord
            injury
  JOURNAL   Glia 67 (1), 125-145 (2019)
   PUBMED   30394599
  REMARK    GeneRIF: In a spinal cord injury model, blocking LAR and PTPalpha
            receptors promotes oligodendrogenesis.
REFERENCE   2  (bases 1 to 7604)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: This study showed that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 7604)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7604)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   5  (bases 1 to 7604)
  AUTHORS   Song,Y.S., Lee,H.J., Prosselkov,P., Itohara,S. and Kim,E.
  TITLE     Trans-induced cis interaction in the tripartite NGL-1, netrin-G1
            and LAR adhesion complex promotes development of excitatory
            synapses
  JOURNAL   J Cell Sci 126 (Pt 21), 4926-4938 (2013)
   PUBMED   23986473
REFERENCE   6  (bases 1 to 7604)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Increased abundance of specific skeletal muscle protein-tyrosine
            phosphatases in a genetic model of insulin-resistant obesity and
            diabetes mellitus
  JOURNAL   Metabolism 44 (9), 1175-1184 (1995)
   PUBMED   7666792
REFERENCE   7  (bases 1 to 7604)
  AUTHORS   Ahmad,F., Considine,R.V. and Goldstein,B.J.
  TITLE     Increased abundance of the receptor-type protein-tyrosine
            phosphatase LAR accounts for the elevated insulin receptor
            dephosphorylating activity in adipose tissue of obese human
            subjects
  JOURNAL   J Clin Invest 95 (6), 2806-2812 (1995)
   PUBMED   7769120
REFERENCE   8  (bases 1 to 7604)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 7604)
  AUTHORS   Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E.
  TITLE     Cloning, bacterial expression, purification, and characterization
            of the cytoplasmic domain of rat LAR, a receptor-like protein
            tyrosine phosphatase
  JOURNAL   J Biol Chem 266 (29), 19688-19696 (1991)
   PUBMED   1918076
REFERENCE   10 (bases 1 to 7604)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 24, 2025 this sequence version replaced
            XM_039110163.2, NM_019249.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19839.1,
                                           SRR26643295.22390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  137109266-137109453 c
            189-268             JAXUCZ010000005.1  137102816-137102895 c
            269-403             JAXUCZ010000005.1  137095316-137095450 c
            404-549             JAXUCZ010000005.1  137087255-137087400 c
            550-691             JAXUCZ010000005.1  137086942-137087083 c
            692-880             JAXUCZ010000005.1  137074901-137075089 c
            881-991             JAXUCZ010000005.1  137066584-137066694 c
            992-1261            JAXUCZ010000005.1  137056469-137056738 c
            1262-1843           JAXUCZ010000005.1  137054602-137055183 c
            1844-1980           JAXUCZ010000005.1  137054243-137054379 c
            1981-2125           JAXUCZ010000005.1  137053623-137053767 c
            2126-2431           JAXUCZ010000005.1  137049945-137050250 c
            2432-2625           JAXUCZ010000005.1  137049152-137049345 c
            2626-2743           JAXUCZ010000005.1  137045007-137045124 c
            2744-3322           JAXUCZ010000005.1  137044353-137044931 c
            3323-3420           JAXUCZ010000005.1  137043586-137043683 c
            3421-3674           JAXUCZ010000005.1  137043147-137043400 c
            3675-3768           JAXUCZ010000005.1  137042968-137043061 c
            3769-3987           JAXUCZ010000005.1  137042165-137042383 c
            3988-4142           JAXUCZ010000005.1  137041639-137041793 c
            4143-4258           JAXUCZ010000005.1  137039093-137039208 c
            4259-4356           JAXUCZ010000005.1  137035917-137036014 c
            4357-4480           JAXUCZ010000005.1  137032859-137032982 c
            4481-4656           JAXUCZ010000005.1  137032561-137032736 c
            4657-4776           JAXUCZ010000005.1  137031787-137031906 c
            4777-4931           JAXUCZ010000005.1  137031401-137031555 c
            4932-5217           JAXUCZ010000005.1  137031039-137031324 c
            5218-5396           JAXUCZ010000005.1  137030760-137030938 c
            5397-5523           JAXUCZ010000005.1  137030412-137030538 c
            5524-5649           JAXUCZ010000005.1  137030057-137030182 c
            5650-5804           JAXUCZ010000005.1  137029744-137029898 c
            5805-5940           JAXUCZ010000005.1  137029514-137029649 c
            5941-7604           JAXUCZ010000005.1  137027376-137029039 c
FEATURES             Location/Qualifiers
     source          1..7604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7604
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="protein tyrosine phosphatase, receptor type, F"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
     exon            1..188
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="upstream in-frame stop codon"
     exon            189..268
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..403
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..6009
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; receptor-type tyrosine-protein phosphatase F;
                     leukocyte antigen-related (LAR) PTP receptor; leukocyte
                     common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     isoform 3 precursor"
                     /protein_id="NP_062122.2"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
                     /translation="MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSS
                     YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVR
                     VSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQ
                     IRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGA
                     RSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARP
                     NTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAPSGFPQNLR
                     VTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVHLTLLGLKPD
                     TTYDIKVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYK
                     SAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAP
                     DLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPE
                     ELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRP
                     LSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAV
                     ILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH
                     PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAY
                     DHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT
                     VVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEK
                     RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVI
                     DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARN
                     LYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYE
                     LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
                     VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSR
                     TIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFIT
                     LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT"
     sig_peptide     313..399
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     400..6006
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /product="Receptor-type tyrosine-protein phosphatase F.
                     /id=PRO_5000142152"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1)"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..663
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1060..1062
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1197
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    2086..3462
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2086..3462
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2389..2451
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2473..2475
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3133..3135
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3181..3183
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    4075..4137
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     transmembrane region"
     misc_feature    4198..4200
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10586; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); phosphorylation site"
     misc_feature    4288..5115
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    4288..5115
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    5119..5991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     misc_feature    5119..5991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     exon            404..549
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            550..691
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            692..880
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            881..991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1261
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1843
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1980
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2431
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2625
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2743
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..3322
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3420
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3674
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3768
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4142
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4258
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4356
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4480
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4656
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..4776
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4931
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..5217
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5396
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5523
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5524..5649
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5650..5804
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5805..5940
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5941..7604
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcggtg gcggcggcgg cagaggcggc ggctccggct ccagctccgg ctccggctcc
       61 tgttagggcg gcggtggagg tggcggtggc ggtggcggga gcgggcgacg gcggcagcgg
      121 cggactgaga acggcggcct cagcggcgcg aggcggggac atgcagaccg acggcccccg
      181 gagaggcgga aggagcggag gccctggtgc cctgccctca gtgctgactg cccagcgaga
      241 gtgactggta taaacaagaa gagaccgggt gattgtcttg ggctgtggct ggctgtggag
      301 ctagaaccct ggatggcccc cgagccagcg ccagggagga ggatggtgcc ccttgtgcct
      361 gccctcgtga tgctgggttt gatggcaggt gctcatggcg acagcaaacc tgtctttgtt
      421 aaggtccccg aggaccagat cgggctgtcg ggaggggtgg cctccttcgt gtgccaagcc
      481 acaggggaac ccaagcctcg aatcacatgg atgaagaagg gaaagaaagt cagctcccag
      541 cgctttgagg taattgagtt tgacgacgga gcagggtcag tgctgcggat ccagccatta
      601 cgagtgcagc gagacgaagc catctatgag tgcacggcca cgaacagtct cggcgagatc
      661 aacacaagtg ccaagctgtc agtacttgaa gaggaccagc tgccgtctgg gttcccgact
      721 atcgacatgg gacctcaact gaaggtggtg gagaaggctc gcactgccac catgctgtgt
      781 gcagctggtg gaaatccaga ccctgagatc tcttggttca aagacttcct tcctgtggac
      841 cctgcttcaa gcaacggtcg tatcaagcag ctgcgttcag gtgcattgca gattgagagc
      901 agcgaggagt ctgaccaagg caagtacgag tgtgtggcaa ccaactcggc aggcacacgc
      961 tactcggccc ccgccaacct gtatgtgcga gtgcgccgcg tggctcctcg tttctccatc
     1021 cctcccagca gccaagaggt aatgccgggc ggcaacgtga acctcacgtg tgtggcagtg
     1081 ggagcaccca tgccgtatgt gaagtggatg atgggcgccg aggaacttac caaagaggac
     1141 gagatgccag ttggccgcaa tgtgctggag ctcagcaatg tcatgcggtc tgccaactat
     1201 acctgtgtgg ccatctcttc actgggcatg atagaggcca cagcccaggt cacagtaaaa
     1261 gctctgccaa agcctccaat tgatcttgtg gtgacagaga caactgccac cagtgttacc
     1321 ctgacatggg actctggaaa taccgagcct gtgtctttct acggcatcca gtaccgtgca
     1381 gctggcacag atggcccctt ccaggaagtg gatggtgtgg ccagcacccg atacagcatt
     1441 ggtggcctca gccctttttc agaatatgcc ttccgtgtgt tggctgttaa cagcattggg
     1501 cgaggaccac ccagtgaggc agtgcgagcg cgcacgggtg agcaggcacc ctccagccct
     1561 ccacgccgtg tgcaggcccg aatgctgagc gccagcacca tgctggtaca gtgggaaccc
     1621 cctgaagagc ccaatggcct ggtacgggga tatcgagtct actacacccc agactctcga
     1681 cgccccttga gcgcctggca caagcataac accgacgcag gactccttac caccgtgggc
     1741 agcctgctac ctggcatcac ctacagcctc cgcgtcctgg cctttactgc cgtgggcgac
     1801 ggccctccca gccccaccat ccaagtcaag acacagcagg gagtgcctgc acagcctgca
     1861 gacttccagg ccaaagccga gtcggacacc aggatccagc tatcatggct gctgcccccg
     1921 caggagcgga tcatcaagta tgagctggtg tactgggcag cagaggatga aggccagcag
     1981 cacaaggtga ccttcgaccc cacctcctcc tacactctgg aggacctgaa gcctgacaca
     2041 ctgtaccact tccagctggc tgctcgctca gatttggggg tgggcgtctt cactcccacc
     2101 gtagaggccc gtacagcaca gtccacccca tccgcccctc cccagaaggt gacatgtgtg
     2161 agcacgggct ccaccacggt ccgggtaagt tgggttccac cgccggctga cagccgcaac
     2221 ggcattatca cccagtactc cgtggcctat gaggcagtgg acggcgagga ccgtaaacgg
     2281 catgtggtgg atggcatcag ccgtgagcat tccagctggg acctgttggg cctggagaag
     2341 tggacggagt accgggtgtg ggtgcgggca cacacagatg tgggccctgg ccctgagagc
     2401 agcccggtgc tggtgcgcac cgacgaggac gtgcctagcg ggccaccacg gaaggtggag
     2461 gttgagcctc tgaactccac tgctgtgcat gtctcctgga agctgcccgt ccccaacaag
     2521 cagcacggac agattcgtgg ctaccaggtc acctatgtgc ggctggagaa tggggagccc
     2581 cgaggccagc ccatcatcca ggatgtcatg ctggctgagg ctcaggaaac caccatcagc
     2641 ggcctcaccc ccgagaccac ctactccatt actgttgctg cctacaccac taagggggac
     2701 ggtgcccgaa gcaagcccaa agtggttact accacagggg cagtcccagg acggcccacc
     2761 atgatggtca gcaccacggc catgcacacc gcgctgctgc agtggcaccc acccaaggag
     2821 ctgcctggag agctgctggg ctaccggcta caataccgtc gggccgacga ggcgcggccc
     2881 aacaccatag attttggcaa ggatgaccag cattttacag tcaccggtct gcacaaaggg
     2941 gccacctaca tcttccggct ggctgccaag aaccgggctg gcccaggtga agagtttgag
     3001 aaagagatca cgacccccga ggatgcgccc agtggctttc ctcaaaacct ccgagtgaca
     3061 ggactgacca cgtctaccac ggaactggcc tgggacccgc cggtgctggc agagaggaat
     3121 ggtcgcatca ccaactatac cgtggtctac cgtgacatca acagccagca tgaactccag
     3181 aatgtcactg gtgatgtaca ccttacactc ttgggcctca aaccggacac cacttatgac
     3241 atcaaggtcc gtgcacatac cagcaaaggc gccggcccac tcagccccag catccagtcc
     3301 cagaccatgc ccatggagca agtgtttgcc aagaatttcc gtgtggccgc tgcaatgaag
     3361 acatctgtgc tgctcagttg ggaggtcccc gactcttaca agtcagctgt acccttcaag
     3421 atcctgtaca atgggcagag cgtggaggtg gatgggcact ccatgcggaa gctgattgca
     3481 gacctgcaac ccaacacgga gtactccttc gtcctgatga accgcggcag cagcgctggg
     3541 ggcctacagc acctggtgtc catccgcact gccccagacc tcctgcctca gaagccactg
     3601 cctgcctctg cctttataga ggatggccgc ttctccctct ccatgcctca agtgcaggac
     3661 ccctcgctag tcaggtggtt ctacattgtg gtggtgccca ttgaccgtgt gggcgggaac
     3721 ctgctggcac caagatggag cacaccagag gagctggagc tggacgagct tctggaggcc
     3781 atcgagcagg gtgaggagaa acagcggagg cgtcggcgcc aagcagagcg gctgaagcct
     3841 tacgtggcag ctcaagtgga cgagctccct gagaccttca ccctggggga caagaagaac
     3901 taccgtggct tctacaaccg gcccctgtct ccggatctga gttaccagtg ctttgtgctc
     3961 gcctccctca aggaacccat ggaccagaag cgctatgcct ccagccccta ctcggacgag
     4021 atcgtagtcc aggtgacacc agcccagcag caggaggagc ccgagatgct gtgggtgaca
     4081 ggccctgtcc tggcagtcat tctcatcata ctcattgtca tcgctatcct cctattcaag
     4141 aggaagagaa cacattcccc atcgtcaaag gatgagcagt caatcgggct gaaggactcc
     4201 ctgttggccc actcttctga ccctgtggaa atgcgaaggc ttaactacca gaccccaggt
     4261 atgcgagacc acccgcccat ccccatcact gacctggcag acaatattga acgtctcaaa
     4321 gccaatgatg ggctcaagtt ctcccaggag tatgagtcca ttgaccctgg acagcagttc
     4381 acgtgggaga attccaactc agaggtgaac aagcccaaga accgctatgc aaacgtcatt
     4441 gcctatgacc actctcgagt cctcctcacc tccattgatg gtgttcctgg gagtgactac
     4501 atcaatgcca actacattga tggctaccga aagcagaatg cctacatcgc cacacagggt
     4561 ccgctgcctg agaccatggg tgatttctgg aggatggtgt gggaacagcg tacagccaca
     4621 gtggtcatga tgaccaggct agaggagaaa tcccgggtga agtgtgatca gtattggcca
     4681 gcccgtggca ctgagaccta tggcctcatt caggtgaccc tggtggacac tgtggagttg
     4741 gccacgtaca ccatgcgcac cttcgcactc cataagagcg gctccagtga gaagcgtgag
     4801 ctgcgtcagt tccagttcat ggcctggcca gaccatgggg ttcctgagta ccccactccc
     4861 atcttggcct tcctgagacg ggtcaaggcc tgtaacccgc tagatgcagg acccatggtg
     4921 gtgcattgca gtgctggtgt gggccgcacg ggctgcttca ttgtcatcga cgcaatgctg
     4981 gagcgtatga agcacgagaa gacagttgac atctatggcc acgtgacgtg catgcgctcg
     5041 caaaggaact acatggtgca gacagaggac cagtatgtgt tcatccacga ggcactgtta
     5101 gaggctgcca tgtgcggaca cactgaggtg cttgctcgaa acctctatgc ccacatccag
     5161 aagctaggcc aagtgcctcc cggggagagt gtcactgcca tggagcttga gttcaagttg
     5221 ctggccaact ccaaggccca cacgtctcgc ttcattagtg ccaacctgcc ctgcaacaag
     5281 ttcaagaacc gcctggtgaa catcatgccc tatgagctga ctcgagtgtg cctgcaaccc
     5341 atccgtggtg tggagggctc tgactacatc aatgccagct ttctagatgg ctacagacag
     5401 cagaaggcct acatagctac acaggggcct ctggccgaga gcaccgagga cttctggcgc
     5461 atgttatggg agcacaattc caccatcatc gtcatgctga cgaagcttcg ggagatgggc
     5521 agggagaaat gtcaccagta ctggccagca gagcgctctg ctcgctatca atactttgtc
     5581 gttgacccga tggctgagta caacatgccc cagtatatcc tgcgtgaatt caaagtcaca
     5641 gatgcccggg atgggcagtc aaggacaatc cgacagttcc agtttacaga ctggccagag
     5701 caaggagtac ccaagacggg ggaaggcttc atcgacttca tcgggcaggt gcacaagaca
     5761 aaggagcagt ttggacagga tgggcccatc acagtacact gcagtgctgg tgtgggccgc
     5821 acaggggtgt ttatcaccct gagcattgtc ctggagcgca tgcggtacga gggcgtggtt
     5881 gacatgttcc agaccgtgaa gaccctccgc acacagcgcc ctgcaatggt gcagacagag
     5941 gaccaatacc agctgtgcta ccgtgcggcc ctggaatacc tcggcagctt tgatcactat
     6001 gcaacgtaac tactgctccc ctctcctccg ccgctcccct gaggggctcc ggaggggacc
     6061 cagctcctct gagccatacc gaccatcgtc cagccctcct gcacggatgc tgttgccggc
     6121 agagcacagc ccactgggat cacagcattt cgggaacatt gccacaccag tcagagagcc
     6181 cagaacacct gggcaagtag gcggactggc agcctggctc tgggccctcg tccaccgggc
     6241 ccaagtggag ccctgcttca agctctctgt tcagctccgc gattctcatg cttctcatgg
     6301 ggtgggaaag ggggcagagc cccccacgtt ttatacattt aggcggggta gactgcgggg
     6361 tcctagcctc ttcctccgac tttccttttg caggtctttc actacagatt gggctgctgt
     6421 gggagttggg acttacttgt tttccttttt gagttcacgt tggatccttg tacaacttct
     6481 gcggaaggac acagtacacg ctttccttcc tcgagcagag ctagggccct acctgagcaa
     6541 gtcggctgtg gcccgggagg cagctgagac tcctgctgtc ctccagcctt tcagaggaga
     6601 tcctattcca gccaaatgca gggaaacact ttattttgtt ttaggttttg tttttccttg
     6661 agagcctttt tttaggcccc acagacagtg gtgggcgggg aggcgatagg aaacacatcc
     6721 ccagtgtgca tttaacattc atagcctaca accacagacg tgtctggggg gagcctggca
     6781 aggcgttcct cgtcaccatc gtgtttgcaa aggttcaaaa aagcaaaaat taaaaaaaaa
     6841 aaacataaaa atattttttt ttaaaaaaaa gaaataaaga ttcatcccct ggcctctcct
     6901 tctgctccga agtgggaggc aactcaatgt gcctggggct cgttgtgggc ccacagagtc
     6961 ttgctgtcat ccccagcggt gcagtgtggc aggtgtttgt aagctgtggg ttctggccac
     7021 ctcggtaact gaatggcaca ggtgagggcc tgtgccacgc cccacacacc tcagggccaa
     7081 gcgggggcgt ggccggccct tcaggtctag gccagtgggc ctggtagcac atgtctgtcc
     7141 tcagcgggac agatgctttc tctcctggtt tgcagctgtc ttcaaatccc ccatgactcg
     7201 cccttcccac tccttcaagt cgccctcaca aaccaatgtg gcaagactac tggacttgta
     7261 tccatggtac tctactcagt cctcttatct cagcttgctg aggggcaggg agagggtctc
     7321 ttcctctggg cagcactatc taggtagtaa gtgggggcgg gaaagggtgc atagctgttt
     7381 tagccgaagg actcgatgtg gacgtcctca gatatagcta ggctaagcgg agatcgacgg
     7441 tccggggttg gtggtgttgg atgagacatt catttttacc ttgtggacgc tagtgctgta
     7501 gagttcactg ttgtacacag tctgttttct atttgttaag gaaaactaca gcatcattgc
     7561 atacttcttg atggtaataa atttgaataa tcagatttct taca
//
LOCUS       NM_001007703            1937 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus ceramide-1-phosphate transfer protein (Cptp),
            transcript variant 2, mRNA.
ACCESSION   NM_001007703 XM_233718
VERSION     NM_001007703.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Mishra,S.K., Gao,Y.G., Deng,Y., Chalfant,C.E., Hinchcliffe,E.H. and
            Brown,R.E.
  TITLE     CPTP: A sphingolipid transfer protein that regulates autophagy and
            inflammasome activation
  JOURNAL   Autophagy 14 (5), 862-879 (2018)
   PUBMED   29164996
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Simanshu,D.K., Kamlekar,R.K., Wijesinghe,D.S., Zou,X., Zhai,X.,
            Mishra,S.K., Molotkovsky,J.G., Malinina,L., Hinchcliffe,E.H.,
            Chalfant,C.E., Brown,R.E. and Patel,D.J.
  TITLE     Non-vesicular trafficking by a ceramide-1-phosphate transfer
            protein regulates eicosanoids
  JOURNAL   Nature 500 (7463), 463-467 (2013)
   PUBMED   23863933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001007703.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083599.1, SRR26643295.24081.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000005.1  171760996-171761230 c
            236-370             JAXUCZ010000005.1  171758958-171759092 c
            371-1937            JAXUCZ010000005.1  171757181-171758747 c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1937
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="ceramide-1-phosphate transfer protein"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
     exon            1..235
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    162..164
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="upstream in-frame stop codon"
     exon            236..370
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..899
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="isoform a is encoded by transcript variant 2;
                     glycolipid transfer protein domain-containing protein 1;
                     glycolipid transfer protein domain containing 1"
                     /codon_start=1
                     /product="ceramide-1-phosphate transfer protein isoform a"
                     /protein_id="NP_001007704.1"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
                     /translation="MDGPERDFNLKVVLISFKKCLTDKGEVLLDHYTASWKGLVRFLN
                     SLGAVFSFISKDVVSKLQIMEHLRSGPQSEHYISLQSMVAYEVSNKLVDRDSRSRPRH
                     PNSGCRTVLRLHRALHWLQLFLEGLRTSSEDARTSTLCSEAYNATLAAYHSWIVRQAV
                     NVAFHALPPRKVFLEAMNMGSSEQAVEMLGEALPFIEQVYDISQKLYAEHSLLDLP"
     misc_feature    327..773
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
     misc_feature    327..773
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
     exon            371..1937
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccgcaggc tgcgagcttg ggggaaagca tagggatggg agctcttacc tgacagtgaa
       61 ctaggcagca gagccatgcc tctgtagacc accggaacgg agggcaaaga ttcgtcaccc
      121 acagcagcct aattatagct ttgatcaacc ccccccatca ctgaccttcc ctgcaccctt
      181 tgccctccgc gggagtaaag aaccaccact caccccccac cggaacccgt ctcagttcgt
      241 gttggaagat ggatggccca gagagagatt tcaaccttaa ggttgtcctg atcagcttca
      301 agaagtgtct cactgacaag ggagaggtgc tgctggacca ctatactgcc agctggaagg
      361 ggcttgtcag gtttctgaac agcctagggg ctgtcttttc attcatctcc aaggatgtgg
      421 tctcaaagct tcagattatg gagcatctga gaagtggccc acagtctgaa cactacatta
      481 gcttgcaatc catggtagcc tacgaggtga gcaacaagct ggtggacaga gacagccgct
      541 cacgtccccg acaccctaac tcaggctgcc ggactgtgct gcgcctacac cgtgctctgc
      601 attggctaca gctgttcctg gaaggcctgc gcaccagctc tgaggatgct cgtacctcca
      661 ccctctgcag tgaggcctac aatgccacac tggctgccta tcactcctgg atagtacgtc
      721 aagctgtcaa tgtggccttc catgccttgc ccccacgcaa ggtcttcctt gaggccatga
      781 atatggggtc ctctgagcaa gcagtggaga tgctgggaga ggccctgccc ttcattgagc
      841 aagtgtatga catctcccag aagctctatg ctgaacattc cctgctagac ctgccctagt
      901 agtggtaacc atactgtgtg gacttcccct gctcagaact gggtttgggc aatctagggc
      961 tactcccaca gcagggcttt ctggaaacta ctgtcacccc tgtaagctga actggtggaa
     1021 agccagtctg tgaaaagaaa ggtcgtgggc agctgaacca agaaaggtga atgctagtca
     1081 tcctcttggt tcaggatgag acagttgaac tccagttttg ccctccactt cagtcatgtg
     1141 ttcagtcagg cttgattgaa gtgcagatgg aaaatggaga agtggggggc ggtgtcatgt
     1201 atctgcaaca acccaaggtt gctctacctc tcctgtatag aatctgaaat ggtataagga
     1261 cccaggaccc aggagctgtc ttccctacag ccaacatgcc cagccaatgt gtatcctaca
     1321 tgtctggggc cccttcatat tccaaaagct gtaacatggg taacatgaag ttcctctggc
     1381 agtggcatga gtccctgccc ttcacctgct tccttgttag tctctctgca taccaaacag
     1441 gcccttgcct ccttggaaat ggaaactgta tgaaaccaat agctgaggct tctctaagaa
     1501 agcctgccct ggtcagtgca gcctgttcca cagcttctcc agtatagtac cgtcagcctt
     1561 ctgaaggtgg cttcttacaa cacatgtacc cccaggattc taagatgtca atactaactg
     1621 gccaaaccat acctctctct agccagccct gctgctcctg ttgccataat acgcagatga
     1681 cttaggacat gacttgtggg aggagactag gcccctttgt ctgacagatg gccataccta
     1741 gcatggctaa tacccagtgt ataagaccat aagctttccc actgggtctt aatgttaaac
     1801 ccgaggacaa tgccctcagc gtagctgatg tgtgcaaatg caaactttgg ggggcacatc
     1861 tctttcctta agaattgtga tctatgtatt tccaacataa ataaattaca cctacatgat
     1921 tgggtatagc actctgg
//
LOCUS       NM_001436872            4444 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus calsyntenin 1 (Clstn1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436872 XM_039110102
VERSION     NM_001436872.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4444)
  AUTHORS   Zhou,F., Hu,R., Wang,Y., Wu,X., Chen,X., Xi,Z. and Zeng,K.
  TITLE     Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models
  JOURNAL   Synapse 78 (5), e22307 (2024)
   PUBMED   39171546
  REMARK    GeneRIF: Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models.
REFERENCE   2  (bases 1 to 4444)
  AUTHORS   Ster,J., Steuble,M., Orlando,C., Diep,T.M., Akhmedov,A.,
            Raineteau,O., Pernet,V., Sonderegger,P. and Gerber,U.
  TITLE     Calsyntenin-1 regulates targeting of dendritic NMDA receptors and
            dendritic spine maturation in CA1 hippocampal pyramidal cells
            during postnatal development
  JOURNAL   J Neurosci 34 (26), 8716-8727 (2014)
   PUBMED   24966372
REFERENCE   3  (bases 1 to 4444)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   4  (bases 1 to 4444)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4444)
  AUTHORS   Vagnoni,A., Perkinton,M.S., Gray,E.H., Francis,P.T., Noble,W. and
            Miller,C.C.
  TITLE     Calsyntenin-1 mediates axonal transport of the amyloid precursor
            protein and regulates Abeta production
  JOURNAL   Hum Mol Genet 21 (13), 2845-2854 (2012)
   PUBMED   22434822
  REMARK    GeneRIF: findings show that amyloid precursor protein (APP) and
            calsyntenin-1 are co-transported through axons, that loss of
            calsyntenin-1 disrupts axonal transport of APP and that
            calsyntenin-1 loss also leads to altered APP processing and
            increased production of Abeta
REFERENCE   6  (bases 1 to 4444)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4444)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
  REMARK    GeneRIF: Calsyntenin-1 links a certain type of vesicular and
            tubulovesicular organelles to the Kinesin-1 motor.
REFERENCE   8  (bases 1 to 4444)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   9  (bases 1 to 4444)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4444)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110102.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.15012.1,
                                           SRR26643295.23837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000005.1  165314338-165314634
            298-420             JAXUCZ010000005.1  165347091-165347213
            421-450             JAXUCZ010000005.1  165356823-165356852
            451-646             JAXUCZ010000005.1  165357948-165358143
            647-855             JAXUCZ010000005.1  165359104-165359312
            856-1005            JAXUCZ010000005.1  165361662-165361811
            1006-1191           JAXUCZ010000005.1  165362057-165362242
            1192-1440           JAXUCZ010000005.1  165364336-165364584
            1441-1562           JAXUCZ010000005.1  165364894-165365015
            1563-1725           JAXUCZ010000005.1  165367642-165367804
            1726-1883           JAXUCZ010000005.1  165372011-165372168
            1884-2032           JAXUCZ010000005.1  165372364-165372512
            2033-2259           JAXUCZ010000005.1  165372762-165372988
            2260-2430           JAXUCZ010000005.1  165373487-165373657
            2431-2576           JAXUCZ010000005.1  165373961-165374106
            2577-2712           JAXUCZ010000005.1  165375061-165375196
            2713-2897           JAXUCZ010000005.1  165375492-165375676
            2898-4444           JAXUCZ010000005.1  165376081-165377627
FEATURES             Location/Qualifiers
     source          1..4444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4444
                     /gene="Clstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
     exon            1..297
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3095
                     /gene="Clstn1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; alc-alpha; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 3 precursor"
                     /protein_id="NP_001423801.1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
                     /translation="MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVD
                     KSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEY
                     APVFKEKSYKAAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGY
                     IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEP
                     GTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGT
                     SELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWM
                     RHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKL
                     NQVCDEDWHHFVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQGG
                     DLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQ
                     AVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEG
                     YVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAED
                     PTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVF
                     TGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTAN
                     PVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMI
                     ILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEE
                     EESEDGEEEEDITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY"
     sig_peptide     207..290
                     /gene="Clstn1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    327..683
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    327..683
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,555..557,561..563,672..674,678..683)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,555..557,561..563,672..674,678..683)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    708..980
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    708..980
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1299..1781
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1299..1781
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1302..1304
                     /gene="Clstn1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6Q0N0.1); glycosylation site"
     misc_feature    1845..2903
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    1845..2903
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    2619..2624
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     mat_peptide     2625..3092
                     /gene="Clstn1"
                     /product="CTF1-alpha. /evidence=ECO:0000250.
                     /id=PRO_0000323603"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1)"
     misc_feature    2706..2711
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     misc_feature    2727..2789
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     transmembrane region"
     misc_feature    2892..3092
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            298..420
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..450
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..646
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..855
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1005
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1191
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1440
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1562
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1725
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1883
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2032
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2259
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2430
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2576
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2712
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2897
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..4444
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccgcc gccgccgcct ccagcgcagc gctgccgacg aggggagggc gcgcgcggcc
       61 cagcagcacg gcggctgccg ctcacatccc ggtgctcgcc gcgccgccca gccgctggcc
      121 cccggctgcc cgcacccctc tcggcgtccc gcgcgactcc ctgctgcttc cgcgtcgggc
      181 cggccgcggc gctccgagcc cgagcgatgc tgcgccgccc tgcgcccgcg ctggcccggg
      241 ctgtccggct gctgctggcg gggctgctgt acggcggcgg ggtctgggcc gcgcgagtta
      301 acaagcacaa gccatggctg gagcccacct accacgggat cgtcaccgag aacgataaca
      361 cggtgctgct cgaccccccc ctcatcgccc tggacaaaga ctcaccgctg cgctttgcag
      421 agagttttga ggtgacagtc accaaagaag gtgagatttg tggctttaaa atccacgggc
      481 agaatgtccc cttcgatgcc gtggtagtgg ataagtccac gggtgaggga ataatccgat
      541 caaaagagaa actggactgt gagttgcaga aagactatac attcaccatc caggcctacg
      601 actgcgggaa gggacccgat ggcaccggtg tgaaaaaatc tcacaaagca accgtgcaca
      661 tccaggtgaa cgacgtgaat gagtacgccc ccgtgttcaa ggagaagtcg tacaaggcgg
      721 ccgtggtgga gggcaagcag cacggcagca tcctcagggt ggaggccgtg gatgcagact
      781 gctcgcccca gttcagccag atctgcagct atgagattct caccccagat gtgccgttca
      841 ctgtggacaa agacggttac atcaaaaaca cagagaagct taactacggc aaagagcatc
      901 agtataagct cactgtcacc gcctatgact gtgggaagaa aagagccacg gaggacgtcc
      961 tggtgaagat cagcgttaag cccacctgca gccccgggtg gcaaggctgg agcagcagaa
     1021 ttgaatatga gcccggcaca ggcgctttgg ccgtcttccc gagcatccac ttggagacct
     1081 gcgacgagcc tgtcgcctct gtgcaggcca cagtggagct ggagaccagc cacataggga
     1141 aaggctgcga ccgagacacc tactccgaga agtccctcca ccggctctgt ggggctgctg
     1201 ctggtacctc agagctgctc ccgtcgccca gtagctcctt caattggacc gtcggcctcc
     1261 ccactgacaa cggccatgac agtgaccagg tctttgagtt caatggcaca caggcggtgc
     1321 ggatcccaga cggtgttgtg acccttgacc ccaaagagcc ttttacaatt tccgtgtgga
     1381 tgcggcatgg gccttttggc cggaagaagg agacaattct ctgcagttcg gataaaacag
     1441 atatgaaccg acaccattat tcgctctatg tccacgggtg cagactcatt ttcctcctcc
     1501 gtcaggaccc gtctgaggag aagaagtaca ggcctgcgga gttccactgg aagctgaacc
     1561 aagtctgtga tgaggattgg caccactttg tcctcaatgt ggaagtccca agtgtgaccc
     1621 tctatgtgga cggcgtctct catgagccct tctccgtgac cgaggactac ccacttcatc
     1681 caaccaaaat agaaactcag cttgtggtcg gagcttgctg gcaaggtggt gacctgcaca
     1741 tgacgcagtt tttccgaggt aacctggctg gcctcacagt ccgttctggg aaactggcag
     1801 ataagaaagt gatcgactgt ctgtacacct gcaaagaggg gctggacctg caggtccctg
     1861 aggatggcaa cagaggggtg cagatccaaa caagctccag tcaggcggta ttgaccttgg
     1921 agggggagaa tgtcggagag ttggataagg ccatgcagca catttcttac ctcaactcaa
     1981 ggcagttccc cacaccaggc atccgcaggc tgaaaatcac cagcaccgtc aagtgcttta
     2041 atgaggcggc ttgcatcgag gtgcctccgg tggagggcta cgtgatggtt ttacagccag
     2101 aagaacccaa gatcagcctg agtggggtcc accactttgc ccgcgcagct tccgagtttg
     2161 agagcccgga gggtgtttcc cttttccctg agctgaaaat cataagcacc atcaccagag
     2221 aggtggagcc cgaggcggac ggggctgagg accccacagt gcaagagtcc ctggtgtcgg
     2281 aggagattgt gcacgacctg gacacctgtg aggtcacggt ggaaggggag gagctgaacg
     2341 cagagcagga gagcctagag gtggacgtgg cccgcctcca gcagaagggc atcgaagtga
     2401 accactctga cctgggcgtg gtcttcacag gtgtggaaac catggcaagc tacgaggagg
     2461 ttctgcacct cctgcgctat cggaattggc acaccaggtc cctgctggac cggaagttca
     2521 agctcatttg ctcggaacta aatggtcgtt acctcagcaa cgagttcaag gtggaggtga
     2581 atgtgatcca cacagccaac cccgtggaac acgctaatca catggccgcc cagccacagt
     2641 ttgtccaccc tgaacaccga tccttcgtgg acctgtctgg tcacaacttg gccagtcctc
     2701 acccatttgc agttgtcccc agcacggcga ctgtcgtgat tgtggtatgt gtcagcttcc
     2761 tggttttcat gatcatcctg ggggtgtttc ggatccgagc tgcacatcag cgaacgatgc
     2821 gggaccagga caccgggaag gagaacgaga tggactggga tgactctgcc ttgaccatca
     2881 ctgtcaaccc catggagacg tacgaggacc agcacagcag tgaggaggag gaagaagagg
     2941 aagaggagga ggagagtgaa gacggggagg aggaggagga catcaccagt gccgagtcag
     3001 agagcagtga ggaggaggaa ggcggccccg gggacggcca gaacaccacc cggcagcagc
     3061 agctagaatg ggactactcc acactcagct actaaacacg cgctcgccca gcacctgctc
     3121 tccagactct cccagccatc ttccagcccc acgggtccac gatgtacaaa tcattttgac
     3181 cagcaggtct gcagacccct cccccattgc tgaaagtcct cccgtgcttg gtgtgtggga
     3241 ccacaggctc cgccctccct gcccatcacg cttgcagttt tgcttaggag ctggcccttc
     3301 ctcccagtgc aggggcccca cagcacctca gaccccaagt gtgtctggag tcccctgtca
     3361 gccagggaga ggacaccagc acctgggacc tccagagaag ccgcagtgag cggacttgtc
     3421 gacagagggt aaaaaattac tcccacgcag tcatcatttt tcttcatttt taaaagtttt
     3481 tatttttatt ttccaatata gtgcatgtat aaagtgggag agcggggagg gggggttaat
     3541 atgtagatga ccaactgact ttttaatatt ttgtaaataa attgggattc tttgtgtcct
     3601 ttgtgctagt gtagtccagg acaggaatgt gaagtcagaa catggggcca ggaagagctc
     3661 ttcctccctt ttccctccca agaaaccagg ttggaaaggt ccaagtcaca gtggcccatg
     3721 ctggggtttc tgtacagcca tgtggccagg gccataggtt ttgagtgctg cctgggggag
     3781 ccagacccac gcgctcccac cacattagag gctgggaaca gccaggatgg tgccaaagcc
     3841 cctggccttc cttgtacacg cctgtgacca gcctcgtggc ttctgctaat tagcgtgtct
     3901 ccctgttggt gaaaacctgt agctgggaac tgatggcaaa gatggacaac agttctgagc
     3961 agtctgcact acagcaccca agaggagaac ctgaggcccg aaaacaaact gctacaatgt
     4021 ttcaaaacga gctgcgctct cctccccaga gaccccacgg gatgcccccg ggatgccccc
     4081 ttgctgtcgg gttttggcta agacctaaga cccagcagag gagagccagc cggcttgggg
     4141 ggtgggggtg ggggaggaga cagcagctaa aacccacaca gcacggcttg tcattcacag
     4201 tcacagttta gactcctcca gctggggaat ccggtcctcg ctgctagtcc taaggatgtt
     4261 gacgctgtgc tgcctgtggc caccctcccg tgtcctgttc cctgtagtcg ctttatagat
     4321 ggaaacaggc tatgaagagg gacactgtcg tgtgttggta gccgcaggct ccccttaaga
     4381 tgtgtatatt gaccccaggt caggaagtgt atgcgttata ataaagttct ggttctaact
     4441 ccaa
//
LOCUS       NM_031647               7975 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus Scm-like with four mbt domains 1 (Sfmbt1),
            transcript variant 2, mRNA.
ACCESSION   NM_031647
VERSION     NM_031647.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7975)
  AUTHORS   Zhang,J., Bonasio,R., Strino,F., Kluger,Y., Holloway,J.K.,
            Modzelewski,A.J., Cohen,P.E. and Reinberg,D.
  TITLE     SFMBT1 functions with LSD1 to regulate expression of canonical
            histone genes and chromatin-related factors
  JOURNAL   Genes Dev 27 (7), 749-766 (2013)
   PUBMED   23592795
REFERENCE   2  (bases 1 to 7975)
  AUTHORS   Lin,S., Shen,H., Li,J.L., Tang,S., Gu,Y., Chen,Z., Hu,C.,
            Rice,J.C., Lu,J. and Wu,L.
  TITLE     Proteomic and functional analyses reveal the role of chromatin
            reader SFMBT1 in regulating epigenetic silencing and the myogenic
            gene program
  JOURNAL   J Biol Chem 288 (9), 6238-6247 (2013)
   PUBMED   23349461
REFERENCE   3  (bases 1 to 7975)
  AUTHORS   Wu,S., Trievel,R.C. and Rice,J.C.
  TITLE     Human SFMBT is a transcriptional repressor protein that selectively
            binds the N-terminal tail of histone H3
  JOURNAL   FEBS Lett 581 (17), 3289-3296 (2007)
   PUBMED   17599839
REFERENCE   4  (bases 1 to 7975)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 7975)
  AUTHORS   Usui,H., Ichikawa,T., Kobayashi,K. and Kumanishi,T.
  TITLE     Cloning of a novel murine gene Sfmbt, Scm-related gene containing
            four mbt domains, structurally belonging to the Polycomb group of
            genes
  JOURNAL   Gene 248 (1-2), 127-135 (2000)
   PUBMED   10806358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced NM_031647.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               JAXUCZ010000016.1  5897677-5898077
            402-540             JAXUCZ010000016.1  5958632-5958770
            541-635             JAXUCZ010000016.1  5963348-5963442
            636-876             JAXUCZ010000016.1  5967243-5967483
            877-965             JAXUCZ010000016.1  5972540-5972628
            966-1212            JAXUCZ010000016.1  5974739-5974985
            1213-1301           JAXUCZ010000016.1  5975505-5975593
            1302-1403           JAXUCZ010000016.1  5976527-5976628
            1404-1554           JAXUCZ010000016.1  5978323-5978473
            1555-1637           JAXUCZ010000016.1  5981717-5981799
            1638-1764           JAXUCZ010000016.1  5994334-5994460
            1765-1878           JAXUCZ010000016.1  5995394-5995507
            1879-1921           JAXUCZ010000016.1  5997510-5997552
            1922-1983           JAXUCZ010000016.1  5999669-5999730
            1984-2123           JAXUCZ010000016.1  6000440-6000579
            2124-2233           JAXUCZ010000016.1  6004687-6004796
            2234-2409           JAXUCZ010000016.1  6005740-6005915
            2410-2588           JAXUCZ010000016.1  6008847-6009025
            2589-2834           JAXUCZ010000016.1  6009199-6009444
            2835-2963           JAXUCZ010000016.1  6010622-6010750
            2964-7975           JAXUCZ010000016.1  6011300-6016311
FEATURES             Location/Qualifiers
     source          1..7975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..7975
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Scm-like with four mbt domains 1"
                     /db_xref="GeneID:58967"
                     /db_xref="RGD:61999"
     exon            1..401
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            402..540
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    429..431
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="upstream in-frame stop codon"
     CDS             513..3104
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Scm-related gene containing four mbt domains"
                     /codon_start=1
                     /product="scm-like with four MBT domains protein 1"
                     /protein_id="NP_113835.2"
                     /db_xref="GeneID:58967"
                     /db_xref="RGD:61999"
                     /translation="MNGEQQLDADLGSGVEVEEFSWEDYLEETGATTAPYASFKHVDI
                     CLQSGFAPGMKLEVALRKDPETYWVATVITACEQLLLLRYEGYGEDRKADFWCDIRRA
                     GLYPIGWCQQNKKTLEAPEGIRDKVSDWSAFLQRTLTGACGPPVALLEGLRNGRNPLD
                     LIAPGSRLECQDFRDSVSTWIVTVVENIGGRLKLQYEGLERHDGFEHWLYYLDPFLHH
                     IGWAAQQGYELQPPLAIRHLKNEADWQEILARVKEEEPLPSYLFKDKQVIRTHEFSIN
                     MKLEAVDPWSPFGISPATIAKVFDDKYFLVEIDDLRPEDHARRSFVCHANSPGIFPVQ
                     WSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSVSEHQFKENMKLEAVN
                     PLFPEEVSIATVTAVRGSYLWLQLEGSKKPVPEFIVSVESMNIFPLGWCETNGHPLST
                     PRRARGHKLRKIAVVQPEKQILSSRTVHEGLKNQLNSPHSVMINGKYCCPKIYFNHRC
                     FSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHG
                     CGEVLKAKYKGKSYRATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENC
                     SVLTKTKYTHYYGKKKNKRIGRPPGGHSNLSCALKKTSKRRKRRKNIFVHKKKRSSAS
                     VDNTPVGSPQGSGGEDEDDADDGDDDSLTEGSTSEQQDELHEESEVSEKKSCSPSPTQ
                     SEMSTPLPPDTQTDKREAQTSSLSDGENKPPSPKEIRIEVDERLHLDSNPLKWSVADV
                     VRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFA
                     FYEQFAN"
     misc_feature    570..872
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 1"
     misc_feature    651..932
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    651..932
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    order(690..692,699..701,708..710,714..716,762..764,
                     771..773,789..791)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    order(690..692,699..701,708..710,714..716,762..764,
                     771..773,789..791)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    894..1208
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 2"
     misc_feature    987..1277
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="second malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt2; cd20113"
                     /db_xref="CDD:439103"
     misc_feature    987..1277
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="second malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt2; cd20113"
                     /db_xref="CDD:439103"
     misc_feature    order(1026..1028,1035..1037,1044..1046,1050..1052,
                     1098..1100,1107..1109,1125..1127)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439103"
     misc_feature    order(1026..1028,1035..1037,1044..1046,1050..1052,
                     1098..1100,1107..1109,1125..1127)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439103"
     misc_feature    1236..1550
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 3"
     misc_feature    1323..1604
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="third malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt3; cd20115"
                     /db_xref="CDD:439105"
     misc_feature    1323..1604
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="third malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt3; cd20115"
                     /db_xref="CDD:439105"
     misc_feature    1572..1865
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 4"
     misc_feature    1650..1919
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    1650..1919
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    order(1686..1688,1695..1697,1704..1706,1710..1712,
                     1758..1760,1767..1769,1782..1784)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    order(1686..1688,1695..1697,1704..1706,1710..1712,
                     1758..1760,1767..1769,1782..1784)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    2007..2354
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SLED domain; Region: SLED; pfam12140"
                     /db_xref="CDD:463469"
     misc_feature    2007..2354
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SLED domain; Region: SLED; pfam12140"
                     /db_xref="CDD:463469"
     misc_feature    2424..2831
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2802..2804
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JMD2.2); phosphorylation site"
     misc_feature    2826..2828
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JMD2.2); phosphorylation site"
     misc_feature    2847..3101
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SAM domain of Scm-like-4MBT1,2 proteins of Polycomb
                     group; Region: SAM_Scm-like-4MBT1,2; cd09581"
                     /db_xref="CDD:188980"
     misc_feature    2847..3101
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SAM domain of Scm-like-4MBT1,2 proteins of Polycomb
                     group; Region: SAM_Scm-like-4MBT1,2; cd09581"
                     /db_xref="CDD:188980"
     misc_feature    order(2964..2972,2976..2981,2988..2993,3000..3005,
                     3018..3020)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface ML [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(2964..2972,2976..2981,2988..2993,3000..3005,
                     3018..3020)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface ML [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(3027..3038,3042..3047,3054..3056,3063..3065)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface EH [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(3027..3038,3042..3047,3054..3056,3063..3065)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface EH [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     exon            541..635
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            636..876
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            877..965
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1212
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1301
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1403
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1554
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1637
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1764
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1878
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1921
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1983
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2123
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2233
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2409
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2588
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2834
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2963
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..7975
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacgcgccc gggcacctcg cggccgcggc ggaggccggc ggcgccggga gagagaacgg
       61 gcgagcggcg cgcgtcagcc cagctgggcg cgagaggcca aagtggccgg gtggcggcag
      121 cgggcgccca acttgcaggc tccagtcccc tgcccccatc gagcgccctc ccgccgagcc
      181 cccgcggacc cgcccccccg ggctcgctcc gggcggggcg cgaacccgca gcccgcgcgg
      241 ccgctcaact tcgcagggcc caggcagcag cagcgcggtg accgagagtc taagcctccg
      301 ccgcaaccgg tggctccggc ctcctaggcg cttcgcctgg ggaggcatcg ccgcccgacc
      361 ccctgcgcgg acctggttag cgtctcgagg ccgctgggca ggtccttggg tgccactggg
      421 tagaaacgtg acacttcagg tcatctgtgt atcgcagcag agccctcagc ctgctcatca
      481 ctcggggaag agaacaccca tgtgctgtgg agatgaacgg cgagcagcag cttgatgcag
      541 atctcgggtc tggtgtagaa gtagaggagt tcagctggga agattatctg gaagagacag
      601 gcgccaccac agctccctat gcatcgttta aacatgtgga tatatgtttg caaagtgggt
      661 ttgcccctgg gatgaagctg gaggtggctc tgaggaagga ccctgaaact tactgggtgg
      721 ccaccgtcat tacggcctgt gagcagctgc tcctgctccg ctacgaaggc tatggggagg
      781 accggaaggc agacttctgg tgcgacatca ggagagctgg cctctacccc atcggctggt
      841 gtcagcagaa caagaagacc ctcgaagctc ccgaaggcat cagagataaa gtgtctgact
      901 ggagtgcatt cctacagcgg accctgacag gagcctgtgg tccccctgtg gctctgctag
      961 agggcctccg taacggaagg aatcctttag atctcattgc tccgggatcc agactagaat
     1021 gccaagattt tcgggactct gtaagcacgt ggatagttac tgttgtggag aacattggag
     1081 gacggttgaa gctgcagtat gaaggacttg aaaggcatga tggttttgaa cactggctat
     1141 attacttaga tccgtttctt catcacattg gctgggctgc tcagcaagga tacgaactcc
     1201 agcccccatt agccatcagg catctgaaaa atgaagctga ctggcaagag attttggcca
     1261 gagtgaaaga ggaggagcca ttaccctctt acttatttaa ggataagcaa gttattagaa
     1321 cccatgagtt ttctataaac atgaagttgg aagctgtgga cccatggtct ccttttggga
     1381 tttctcctgc tacaattgct aaggtttttg atgataagta ctttctagtg gaaatagatg
     1441 accttcgacc agaagaccac gcaaggcggt catttgtgtg ccatgctaac agtcctggca
     1501 tctttcctgt gcagtggagt ctaaagaatg gtttacacat caaccctcct ccaggcttcc
     1561 ggagccagga ctttgactgg gccgactacc tcaagcagtg tggtgctgaa gccgctcccc
     1621 agaagtgctt cccgcagtca gtgtctgagc accagttcaa ggagaacatg aagctggagg
     1681 cagtgaaccc tctcttccct gaagaagtga gcatagccac cgtgactgca gtgagaggct
     1741 cttacctgtg gctccagctg gaaggttcta agaagcctgt acccgagttt attgtaagtg
     1801 tggagtcgat gaatatattt cctttgggct ggtgtgaaac caatggccat cctctcagta
     1861 ctcctcgccg ggcacgaggg cataaactga ggaaaattgc agtggttcaa cccgaaaaac
     1921 aaatactgtc ttcaagaact gtccatgaag gcctgaagaa tcagctgaac tccccccact
     1981 cagtgatgat caatggaaaa tactgttgtc caaagatata cttcaaccac cgttgcttct
     2041 cagggccgta tcttaataaa ggaagaattg ctgagctgcc tcagtgtgta ggacctggga
     2101 actgtgttct ggtccttaga gaggtcctta ctttgcttat caacgcagca tacaagccca
     2161 gccgtgtcct ccgagagctc cagctggaca aagactctgt gtggcatggg tgtggagaag
     2221 tcctgaaggc caaatataaa gggaagagct accgagctac tgttgagata gtgagaacag
     2281 cggaccgagt gacggaattc tgccggcaaa catgtatcaa actggaatgc tgtcccaacc
     2341 tctttggtcc acgcatggtt ctggacacat gctctgagaa ctgctctgtc ctgacgaaga
     2401 ccaaatacac acactattat ggaaagaaga aaaataaaag aattgggaga ccacccggtg
     2461 ggcatagtaa tttatcttgt gccctgaaaa aaaccagtaa gaggagaaaa aggcggaaaa
     2521 atatttttgt tcataagaag aaacgctctt ctgcatctgt tgacaatacc ccagtgggct
     2581 caccccaggg aagcgggggt gaggatgagg atgatgccga tgacggagat gatgattcgc
     2641 tcactgaggg cagtacatct gagcaacagg acgagttaca tgaagagtct gaggtgtcag
     2701 aaaaaaaatc atgctcccct tctcccaccc agagtgagat gtccacccca ctgcccccag
     2761 acacacagac ggataaaaga gaggcccaga cttcctcact ctcagatggt gaaaacaagc
     2821 ctccttcacc aaaggaaata agaattgaag ttgatgaaag gcttcacctg gacagtaacc
     2881 cactgaagtg gagtgtggcc gacgtcgtgc ggttcatcag gtccaccgac tgcgctccgt
     2941 tggcaagaat attccttgat caggaaattg atgggcaggc cctcttgctc cttaccctcc
     3001 ccactgttca agagtgcatg gacttaaagt tgggccccgc catcaagctc tgccatcaca
     3061 tagagagaat caagtttgcg ttctatgagc agtttgccaa ctgagaagga caagcagact
     3121 gagctgggtc tttgaagcac agtgcagcaa gccctttgcc ctgctctacg ggcagctgca
     3181 gtcgtcctgg gctatcggcc tgcaagtgct ggcttgctat ctttgcactt tcagggaagg
     3241 agggagcaaa aagagcacaa aatggctctc ctgcaatgga attgtggact tctgtttaga
     3301 agattccagt ttaaaagtcg tgaggaagaa aaaaaaccct taaaagtctg agtgaccatt
     3361 aacgggacct gaaatcaaag aatgactgtg acagctggac cacaccaatt tggttatttt
     3421 cattctgttc cttccctctg tagattgaac tctgttctct gctttctctt tgttgaaaaa
     3481 agaggacata gctttaagtc ggcactggct tgggatggtg cctaaggcac ggcagtgccc
     3541 cactgttgtt gtgtttttaa gcttttctaa attaaagcag ttcattttgg ggatactgaa
     3601 gtggctctag ggttttgaat gtatagtcac acttcgatcc attttaaaat ctgtcttagg
     3661 agttcctttg tttactacct ctgttgatga ctgcgcttac agccatgagt gacatttttt
     3721 gtacgatgcc atttttaagc tgaatgctaa aactatgaca gaaattagag acggcactgc
     3781 ctgctttttt aaaggtatcg tgtcagcacc tacaccccag ccccttcacc agctgtccta
     3841 ggaattccac tcttgtgtcc tccattgtca cccagttttg gccaccgctg ttaagtggct
     3901 ttacaaagta tttcagtctt cactcccccc cccccacccg ttatttctga aaggtattta
     3961 agtggctttg gttttatgct tagttttctg tagagttgtt taactacctc tgtttaattt
     4021 ctggaatttc tactctcagt gaaaatgagt gtgtgttctt tggacccact gtcgagccca
     4081 tttttctggt tttctgggta tgtccaagta gacacatggc agagaaatgt gtctttgggg
     4141 atggcacaaa gtatgaagtt tgttaacagt gtcctcggtt gtgagtactg agaggtagtt
     4201 aagagtctat gaccacgcta cccgaaatgt ccccatcttc tctcctctgg aaagctaagc
     4261 agggcctggt tggtacttgg atgggagatg tggttaagaa gtctagaaat ctctgtctag
     4321 ccacggttat gcctgtcttc agttaagcca atttaaattg aatgtcatta cagtctgaag
     4381 attcccactc agtagctcat tcttttgaag tttttctttt tctttttaat taaactcaag
     4441 ttgacatgaa gctccaggtg aattttcact tacaatggcg ttgttcagtt attaccgaag
     4501 aatagcattt gatctaccac agccaggagt aaagaaagac atgcagacac agttgcctcc
     4561 tttaaagttt tccttgttga ttatttattt atttattttt gattacccta atccctacag
     4621 atttataccc taaacatttt tcctcaagaa ttgaaaatgt tttaaaactg caaacggagt
     4681 aaattctgaa caagcataca aatataaggt catatcatta caaacttaaa ttgtgatttt
     4741 ttttcttttc tcacctcaac tccacctgtt tttatggacc ctgggaacgt ctgtagtgtg
     4801 gatccccctc ttccttggat aaccgtctaa ccgagtctta aagcagcagc tcttcacata
     4861 ggccaccagc aggtgtctct gggaagaagc ttcatttaag taatggttca gttatttgag
     4921 ctttcttaga gatccatctt ctaaaaacat aattctctga tgccatggag agaggcagac
     4981 atggtactag ggagcagatt ggcagactga catgcgtggc tcttcttaga atctccggag
     5041 actgcaggag ttgagtcact gatacaaagg ggagtcatga gaggacatag aacccatgcc
     5101 tacagggtct cacactgtta ccttagtgaa atgaaagggg acagcattga ctctaattta
     5161 cctctctcct tgactcagat cacagaacgt agagctacca gagataacag gtattctgtc
     5221 tggaaggtga agcacacgac ccaaggcctg agtggggctg ggggctgggg ggaaacacaa
     5281 cagtcttgtc ttaggctacc ataattactc aatctctgtg taagttagac aagaggaggg
     5341 cttccctgaa tatgtcttgc acttgtgttg ggataccata cacttgacag tcctagcaaa
     5401 gaatcatcta tcccaacttt cttcacacag aagaggacaa ttaaatgggg attttgcaga
     5461 ggacctttaa gtataaaatt ctaatctcaa actgggtacg gtgatattca cctttaatcc
     5521 caatatttgg gaagaggaaa tggggaatca gaagtctaag atcaaccttg gctacatagt
     5581 gaattctagg ctagcccagg ttatgtgcga tcctgccttt tttaaagatt gttttcattt
     5641 catgtatcta taaagataca aaggttaggc taggtagcag taatggttat gatgctgggg
     5701 tgttttaagt ttgatgatag cttgcattgt tggggtaaat agtttacatg ttacacattt
     5761 gtatgggaaa ctgtctctga gacagccagc ctcaaaattc atagatgttt gctgtaagga
     5821 gactctttgt ctagagttca cctgcagttg ttctcatagc ttgcctgcag tcaagttttt
     5881 tatgatccac cttaaacctg gttgacaaac ttagaaatac atgaacagac tatattgtcc
     5941 tcctagacct caagacttaa cagacccaaa ctagacttta cagctatatt ggtcttctag
     6001 ggaaaccttc aactgtatgt gcagattagt tctgatattt tgactatata tgctgtttcc
     6061 ctttgtgaaa tgtctttgtc ctttttaaat ataggagata cattaatgga gccctttaat
     6121 tacatcttta gcctttcttt agcaatgtac acagctccct gtttttataa tacaggcgta
     6181 ggaagggtac tagccaagct ctagaagtga agatcttggt aaatatttat tgaattttaa
     6241 tagaggcagg catagaaaac cagttcagag tttgaccttt gtatgtctct tcgagagata
     6301 aaagtatttt cactgtgagg gaaagggcat tcgaccaaag cttcctgaag acttgaatac
     6361 cttttacatg ctctttggaa ccactgtagt tactaatgtg aagcctgaag aaggcagata
     6421 ggactcaaaa catcccaccc ctcgcaagcc aacactgttt ccaagagaca cagaaaatga
     6481 ggcagtctaa accataggtg gtagcactgt aaaaactatt gtagaatcat gaaaactgtt
     6541 actgggactt attcttagct ggcacctctc accaaagctt acattgaaga gatcttgtcc
     6601 agtctgagtg actgccacca gtgctgggag agtccttaga ctgtgaaagt aacactgagt
     6661 ttgaacttgc cttacacact gggaatattc tctgtgtaca aagtcacaca cgttcctacg
     6721 cgttcttgtg aagaagtgaa gtagagaact tgggcagaca agatgatcac tttgtaaact
     6781 tggatgtctc tggtcctagg accttggtaa gttctgtgtc ttgtgaccgt gatgctggct
     6841 cagaaactct gtaagaacag agcctcctgt acaaccaaga aatgatggtc actttcctgc
     6901 cattggcttc attttaaatg ttttactcgt gaacattgat gactgctttg tgtgagaatg
     6961 tatgtacttg gggagtttga atttattcta ataagctacc tgttgacctg gagtttcatt
     7021 ctaaggattc taagctcaaa gcgcagtcca gatggatctg gttccaggtg cactcacttg
     7081 tactgtcttc agccacaaag gtcagaatca caagaaccag caacaccagg gtgaaggttt
     7141 gtaggggagg ttgggggatt aaagtagctc taaaactctc ttactttttc tgatgaggct
     7201 ggtgtggtgg gtacaatggc ctaccatggc gaagtgttat gaaagagaca agcaacggat
     7261 tcaccagaca gttgtcatta ccagcagtaa agtgtggaat ggagccatgg gaaacaagga
     7321 agcaagcaag ggagggaggg aacttctgac agagaaacag tgtcaccatt gctgaggtgt
     7381 gagagaggaa cttctctccg tgtgtggaaa ctcaggccgt agggctcctg tagggcttat
     7441 tctgtctagc ttggcagaat tgagggggtc acataatgtc acaacaaggt tatagacttt
     7501 aagggcaggt cacaacgcag atgatcagca gaggacacag acatttacaa agcccaggct
     7561 ggggtaaagc aggcagtctc ctgtcccctt ttgtaagagt tttaagtgct cgtgtttccc
     7621 tcccacttcc ctccctaaag acaatcaggg gctcgccagg atgggactcc aggctgcttc
     7681 cagcaccgtc cttagccctc tctccagtac tctctctttg gaagaaatgc actttgttta
     7741 atgtatttgc ctttaaaaaa ccaaaacaag ttgcttgtct ggaacaaaat gagatgcttt
     7801 tggcactgta tcattcctgc ttgctgtttt tcctcttaat ttaaaatttt atgcattgaa
     7861 gacaaagtac atttaaggag aaatatgcac aagaatacct attaaaataa ctcccatcag
     7921 gtttgatggt ataattttaa aggattaaaa acaaaacaaa actattttga atgaa
//
LOCUS       NM_001436883            3158 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 9, mRNA.
ACCESSION   NM_001436883 XM_063275496
VERSION     NM_001436883.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3158)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3158)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275496.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2299230.1,
                                           SRR21887623.1466001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-3158           JAXUCZ010000016.1  17514185-17515061
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3158
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2383
                     /gene="Eps15l1"
                     /note="isoform 9 is encoded by transcript variant 9;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 9"
                     /protein_id="NP_001423812.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKSPRQEELRVCRHKLQKEVGSPTCLTIQKCPLSL"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..3158
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 gtccccaagg caggaggagt tgagagtctg tagacataag cttcagaaag aggtgggatc
     2341 gcccacatgc ctcacgatac agaagtgtcc tcttagcctg tgaggaccca tcttgggagc
     2401 cctcccccag tggatgcctg accctgtgtt cactgctccc tttgcacttc tggaaaagca
     2461 tgacttgtaa acaaggaaca gttggcaagt ggaagagtca cagcatgctg cagtaaaagt
     2521 tatttcagac tcaggaactg tttttctgga accttttcct cttcatgttc tcagcatgat
     2581 ggaccatgac atgacaaggt ggggcagctg tagtcactgt gccatctctg ctggtctgtc
     2641 cgtcacagta cagatgggga agcaagcaag gcacaggcag ttggactggg atttcagccc
     2701 aggttgagta acccagctca cctctgacca caggggcctg cagcctgacc aggatgatct
     2761 ggaaacttcc gtggacaagc tttgaattaa gattctgcca tttgtgtata aagacttgag
     2821 agtgttctta gtagagtctc tactcctccc tgctctgcag cctgacagcc cgccaggcct
     2881 tcctgcatga agctcctagc tctacagaat aaggatttgg gggcggggga gggggggtct
     2941 ggttaggtct gtgaatctag aggggtgggg gtgggggctg gagagatggc tcagtggtta
     3001 agagcactga ctgctcttcc agaggtcctg agttcaattc ccagcaacca catggtggct
     3061 cacaaccatc tgtaatggga cctgatgccc tcttctggtg tgtctgaaga cagccacaat
     3121 gtatttatat ataataaata aatctgtttt taaaaaga
//
LOCUS       NM_001108657            7414 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 7, mRNA.
ACCESSION   NM_001108657 XM_001053893 XM_342808
VERSION     NM_001108657.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7414)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7414)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7414)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7414)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7414)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7414)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001108657.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26545.1,
                                           SRR26360172.1727209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000005.1  32026962-32027348
            388-525             JAXUCZ010000005.1  32078977-32079114
            526-767             JAXUCZ010000005.1  32081132-32081373
            768-857             JAXUCZ010000005.1  32085402-32085491
            858-1039            JAXUCZ010000005.1  32089757-32089938
            1040-1290           JAXUCZ010000005.1  32102023-32102273
            1291-1376           JAXUCZ010000005.1  32107640-32107725
            1377-1578           JAXUCZ010000005.1  32108284-32108485
            1579-1647           JAXUCZ010000005.1  32117199-32117267
            1648-1838           JAXUCZ010000005.1  32122846-32123036
            1839-7414           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7414
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..387
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    315..317
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="upstream in-frame stop codon"
     CDS             381..2114
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform e is encoded by transcript variant 7;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform e"
                     /protein_id="NP_001102127.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MPDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSF
                     TPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRF
                     LTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKA
                     NLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTP
                     DRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLD
                     DMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLL
                     NCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSGSSSHSRQQSPV
                     NPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHD
                     MITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYC
                     GSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAATPRSTTP
                     GTPSTIETTPR"
     misc_feature    663..932
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    663..932
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1308..1508
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1308..1508
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1626..>1790
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1626..>1790
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1842..1952
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1842..1952
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            388..525
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..767
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..857
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1039
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1290
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1376
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1578
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1647
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1838
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..7414
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttcact ttctgctttt tggtgctctg gaactggggc aggaggaaga gtggagaaag
       61 ggagacagga gttgtgatac tttgtacaca cgtccctgtc cttgttctgc ctgaagagac
      121 agggctgggt tcaaggccac atgtgttcct gtcatcctgc acatttctgc tccaagtgca
      181 atcccgagtg tcagttctcc atctgtctct gcctggcagg cgcacgcgcc cagcaccctg
      241 cctcgggcca tgccgcccca gcccctctga tggccctcct ctccaccgcc ccgcacattc
      301 cagaacagga ggcatgagcc cgcatcgcgc gccctcttaa cacagacttg ctttcactgt
      361 gttacaggct ggattccggg atgcctgatc gtaccgagaa gcactccacg atgccagact
      421 cacctgtgga tgtgaagacg cagtctaggc tgactccccc agcaatgccg cctcctccga
      481 ccactcaagg agccccgaga accagttcgt ttacgccaac gacattaacg aatggcacca
      541 gccattcacc cacggccttg aatggcgccc cctcaccgcc taatggcttt agcaacgggc
      601 cttcctcttc ctcttcctct tctctggcta atcaacagct gcccccagcc tgtggtgcta
      661 gacaactgag caagctgaag cgatttctta ctaccctgca gcagtttggc aatgacattt
      721 caccagagat tggagaaaga gttcgcactc ttgtactagg actggtgaac tctactttga
      781 caattgaaga atttcattcc aaacttcaag aagctactaa cttcccactg agaccttttg
      841 tcatcccgtt tttgaaggcc aacctgcccc tgctacagcg tgaactcctc cactgcgcaa
      901 ggctagccaa acagaaccct gcccagtacc tcgctcagca cgaacagctg cttctggatg
      961 ccagcaccac ctcccctgtc gactcctcag agctgcttct cgatgtgaac gaaaacggga
     1021 agaggcgaac tccagacaga accaaagaaa atggctttga cagagagcct ttgcactcag
     1081 aacatccaag caagcgacca tgcactatta gcccaggcca gcggtacagt ccaaataatg
     1141 gcttatccta ccagccaaat ggcctgcctc accccacccc acctccacct cagcattacc
     1201 gtttggatga tatggccatt gcccaccact acagggactc ctatcgacac cccagccaca
     1261 gggacctcag ggacagaaat agacctatgg ggttacatgg cacacgtcaa gaagaaatga
     1321 ttgaccacag actaacagac agagaatggg cagaagagtg gaagcatctc gatcatctgt
     1381 taaactgcat aatggacatg gtagagaaga cgaggcgatc cctcactgta ctaagacgat
     1441 gtcaggaagc agaccgggaa gaactgaatt actggatccg gaggtacagt gatgctgagg
     1501 acttgaaaaa gggcggcagc ggtagcagca gccactccag gcaacagagc cccgtcaatc
     1561 cggacccagt cgcattagat gcacatcggg aattccttca caggcctgcg tctggatacg
     1621 tgccagagga gatctggaag aaagctgagg aggctgtgaa tgaggtgaag cgacaggcaa
     1681 tgacggagct gcagaaagcc gtgtctgaag ccgagaggaa agcccatgac atgatcacca
     1741 cagagcgagc caaaatggaa cgcacggtgg ctgaagccaa gcggcaggcc gcagaggatg
     1801 ctctggcagt catcaaccag caggaagact ccagtgagag ttgctggaac tgtggccgga
     1861 aagcaagtga gacctgcagc ggctgtaaca cggcccgata ctgtggctct ttttgccagc
     1921 ataaagactg ggagaagcat caccacatct gtggacagac cctgcaggcc ccacagcagg
     1981 gagaaacgcc tgctgtcagc tcctcagtca cgcccagcag tggggctggg agcccaatgg
     2041 acacaccacc agcagccact ccgaggtcta ccacccccgg aaccccctcc accatagaga
     2101 cgacgcctcg ctagacctaa actcagactg tcagaggaaa gacaccacaa ccaacacgaa
     2161 agcaattcct catcctcaga tgctcaaagt cccttttctg tttgtttgtt tatagatgaa
     2221 ctatctatct tatttcagta cttcggcaag agagaaccta actgtatctt tgaggcgata
     2281 gtaaaacaca gaggccagta acgggtcgta atgacttact gtggaaaaca aagatatctt
     2341 ttctttagag aactgaaaag agaggaaaga atataacgtg aaatgctaga tttgacctcc
     2401 tccctgttat tttcaagtag ctgggatttt aaactagatg acctcattaa ccaatgcttt
     2461 accaaacagc aaaccaagag attgctaatt gctgttgaaa gcaaaaatgc taatattaaa
     2521 agtcacagtg ttctttatat acaataatgg aaagaaaaaa aaaaaagagg caattcctca
     2581 agggcacgag cgttggatac agcagtagac attttaacaa gaagatgaat ggcgtctgtg
     2641 ggttgctaac tgaactttga agaccggctg caaaacgcac agatgtgcag cagattggaa
     2701 ggagacacag atgttcgttt tttttccccc gtttctgaaa aagaaataat aatatccagg
     2761 tcaacagaat gaaaaatgaa agatgatttc cagtggggtg tatgactaca gcagcaagaa
     2821 aaaaaaaatt gccataatac aaaggctcct ttttatatca cacacacaca cacacacaca
     2881 cacacacaca cacacacaca cacacacact cactctctct ctccctctct ctctctctta
     2941 agagactcag cctgcagtta attagcattc tggcagcttc caagtcagcc agctgcccta
     3001 aataaccctt caacgtttct tcacttttgc aaggttccac agagtaagac attgaatcta
     3061 ttccagctta ttcattttat atcgaaaaac caattttttt aaaaaaaaaa atggcggctt
     3121 cagctccagc ccctttccaa aatttttcaa ccccaccctg tttgggtttt taattaaaat
     3181 ctagtagttc tcttggtatt aaaacacttc tgtcctgtga ggttttccca atggtgtttt
     3241 tcttgtaaat gtgttggaca aatgtgaaga tgcgttgtag ttgatccata tgcccacatt
     3301 tagtctcttt attcctagtt ggtgagagaa accagtatct ttctatgctg cttttatatc
     3361 tgtatgtatt agtgatattt ctctagtagt taaaaaaaaa aaatgaaaag aaaagaaaaa
     3421 aaaaaaccac actttttttg gttgtcctca agaaaagaag aaaagaaaag aaaagaaaaa
     3481 gctatctttt ggagctgcta actcactctc ttataggatt tttttcctgg aaaccagcat
     3541 gcttcatgga atgctagcac atggatgttt ttaagaggga tgtacataaa tgtattttgc
     3601 actgtcacaa tgactcccta ggcatgcttt ttttttttca aaccaacttt ttaaatatgc
     3661 tagagccatt tcaccaattt tagctgtagc atagagtagt agtggaattt ttcttttatc
     3721 ctttttttta tgaaaaaaaa aattattagg gactttttaa aaaaaaataa aataagatat
     3781 cctactttaa aaaaaaagga cagtgcatgc atattgctgt aaggttgttt aagtatttct
     3841 aattttacaa aaaaaaaatg aaaaaaaaaa tcattagctc tccaaatgct gaggtgtaga
     3901 cggacagctt tagccctgct gagtgccagg ttatacagta ttcttacaaa agggaagtca
     3961 gccaaagact gatctgatgg accaaaatcg gaatttttga aaagcaccag taatcctttc
     4021 caaatgatca gcaggttaaa catgttcagt gtgactccat taacccttcg ttgtccaggg
     4081 tccagaccag aactacttgt tagttttgaa acacattatt agcccaggat gtggttgtgt
     4141 gctttaagag tcggcagtgc tgcaggctgt gtagacaacc aaagttgaaa ggctgggaag
     4201 acacttttcc acatacacat acaccaggca tttctttaca aaattgagta caatccatta
     4261 gcttgtggga ggggggagcg ggtaatgtag cccttggata cagttttaag tggttgtgtt
     4321 ttaagttttc tgcatagatg caatcctcac gggattgctt catgtctcgc aaatctaagg
     4381 tttccttaaa ccatttcccc tgtattttca tataccagtc ggttttgatt ttgtcccggt
     4441 agtgttgtgt tcttttctct tgtcgtcgtc gtcgttgttt tcaatggcct tttagtttag
     4501 gaagttctga tgagcgaatc aatgcatcta tctatctgca tgttggaagt ccatctgcca
     4561 gcacacccgc taaggcaaag agaagcgcat aaccaggctg cgaatgggtt ctattttacc
     4621 atggtgctcc cagaatcctt tgacctcatt ctgctttcta gtctgcttgt gacactggac
     4681 agtcctttct tagagctatt atatgttcta ggctacgaag ggttaaataa tcccaaaaaa
     4741 aataacaaaa aaaaatgagg tatgtcatac cctcgcgtct cgatctcaag aagctgtgat
     4801 gtatgtggaa cagcactgtt attctgaaca ctagtgtgta aaataaggat tagtacagta
     4861 cgtctcattc cttttttaat tcagggcacc ctgagtgaaa accaatacaa aaaaaaaaaa
     4921 aaatccctaa ctctgagctc tgtctctaat tcctcttcct ccttcccctc ttcctcctcc
     4981 tcttcctcta ctcctgtttt gctacattct cctcagtggc aaaaagtttc actctacctc
     5041 tgacagcatg tatattgcac cagtcgctaa cgaaaactgg tctagtcaaa ccaaatgggc
     5101 acaaaagaac caggatacca aaagttaagc tcatacagct gcgaaccata tcacttcttg
     5161 gtaacaatgc agacctcata aacctaaaaa aaaagagaaa gaaaagaaaa cttttgttac
     5221 tttccttttt tgcttgtcac ttatatacag gctatgtgag agtattcatt tgtaggtatt
     5281 acacattaaa aaaaaaaagc tatcttcatt ggatagaact gaatggtggt cgctgatagg
     5341 aatagggcgt cctctatctc ttatctctgt ctcttttctc tttctctttc tctgtcatga
     5401 gactgtgtgt gacagggcta cctgtctttt taatttgttt tctgaacttt ttttttttaa
     5461 tgtgtaggtg catgtcttgg ggatttaaaa atttcaaggc tggtttactt atgcaaagca
     5521 tgcctatgtc tggaatactt agggaaagaa agtgactcca tgttgtccga attcctcaag
     5581 ggacagaaaa acaaattgga gactgttgaa atgcagattt gaagtaattt tatttttaat
     5641 tattttgggt tctgcgacat tattgtgaaa aattaaagtc gttgtgcaat acttaattca
     5701 gacacgtgcc acaagttaac ggtagactaa cactgggggg cgggggctag gcatcacgct
     5761 tttgtctgca tactcttgag cttttaagtc tactatgtct gaactgtggt ttcttgttta
     5821 tccttttttg ttttttcctt agttggactg taatgtatgg tctgtcaacc tgtgaatctt
     5881 taaagtatga ttcaggtatt gttgtactct ttaccgtgta ataaaaatgc ttaaaaaaaa
     5941 aagtcagtag tccgtctccc ttatctttac tgtgtgcccg ccaaggctac cactcaggaa
     6001 cctcattctt gaagggcagt tcttcatgga gcatgcccag agtctagtca gctacagagt
     6061 atgtctctaa cgtgttaatt cgcccacgag tgatgaggga gaaggagaga acacagagga
     6121 catttctgag gtcatagtag tccaatatag aaggatactc caagtcctcc ataagaaagg
     6181 atagcttatg ctaggggtca ccgtctccag aaaggtccaa ttgccatctt tttaaactct
     6241 ggcttgcagc atgtttcttt cattctcagc tgcaggatgt acccactaag gcagatctct
     6301 tcctccatct gtcctggatc ctcaccgcct ttaattagaa gttgccagca tgttcacact
     6361 tggttttgta catttgtaaa tacacagtat gttgtgtcca tcttgtttct gagacccatg
     6421 ttgtccattt aacacgcacc agtatatttt ttttcatgca ctagctataa aaaataactt
     6481 agactttgga gaacctattg gtcatctacc atagaaactc agtcaatttt cacgtacttt
     6541 acacaacaca ttttttaatg actgtatata ctgcattgta gcagaatttc tgatttgctt
     6601 ggaagattcc cgctatggcc taaaactagc ttaaagggat caagtgaaat gcaagaactg
     6661 aatctggaga gacagagaag tcacatagac gctgtcgagt gggaggataa cctagggcct
     6721 tctcttcagt ttcctttgta cgccagctag gcccctatgc ctgtcctgag gcctggcttc
     6781 tccaaatgat gttgagaaat gcagcctatt ttacagagtg aggaagggag cggggaaggg
     6841 agggagggag gagggagaaa gagagagaga gagagagaga gagagagaga gagtttaaaa
     6901 gcatagctag tgcgtatctt attcctacaa aataaacagg ctgagtattt agttttgtag
     6961 ttaatttttc ccctcactcc aaagcctgac cagcgtggct caacttgctt ttcttatttg
     7021 tacagataca ttttcttttt cttttcaaag tggaacagac cagaaaccag aagacatgga
     7081 ggacataact gagatgcctt gaagtagccc ctttataagc tgtccttgaa aaacagctct
     7141 gtgacctatt tgtatgactg gattgctaga caaatgagta atgagtttag tttagaggaa
     7201 gaatgtgaac aaaatcagct tctgggtggt aagcaccatt ttttaaaaga atgtaattga
     7261 tgtatttgat aatataaaaa tgatgtttgc catgaaagaa cactaagtta tttccccaga
     7321 ttggaagggg aagaaatgat caaagaggtg cttttctgta tgggtattta tatctttatt
     7381 tcaaggtgaa tgaataaagt tgtacttgcc taaa
//
LOCUS       NM_001436903            7631 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, F
            (Ptprf), transcript variant 2, mRNA.
ACCESSION   NM_001436903 XM_039110161
VERSION     NM_001436903.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7631)
  AUTHORS   Dyck,S., Kataria,H., Akbari-Kelachayeh,K., Silver,J. and
            Karimi-Abdolrezaee,S.
  TITLE     LAR and PTPsigma receptors are negative regulators of
            oligodendrogenesis and oligodendrocyte integrity in spinal cord
            injury
  JOURNAL   Glia 67 (1), 125-145 (2019)
   PUBMED   30394599
  REMARK    GeneRIF: In a spinal cord injury model, blocking LAR and PTPalpha
            receptors promotes oligodendrogenesis.
REFERENCE   2  (bases 1 to 7631)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: This study showed that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 7631)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7631)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   5  (bases 1 to 7631)
  AUTHORS   Song,Y.S., Lee,H.J., Prosselkov,P., Itohara,S. and Kim,E.
  TITLE     Trans-induced cis interaction in the tripartite NGL-1, netrin-G1
            and LAR adhesion complex promotes development of excitatory
            synapses
  JOURNAL   J Cell Sci 126 (Pt 21), 4926-4938 (2013)
   PUBMED   23986473
REFERENCE   6  (bases 1 to 7631)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Increased abundance of specific skeletal muscle protein-tyrosine
            phosphatases in a genetic model of insulin-resistant obesity and
            diabetes mellitus
  JOURNAL   Metabolism 44 (9), 1175-1184 (1995)
   PUBMED   7666792
REFERENCE   7  (bases 1 to 7631)
  AUTHORS   Ahmad,F., Considine,R.V. and Goldstein,B.J.
  TITLE     Increased abundance of the receptor-type protein-tyrosine
            phosphatase LAR accounts for the elevated insulin receptor
            dephosphorylating activity in adipose tissue of obese human
            subjects
  JOURNAL   J Clin Invest 95 (6), 2806-2812 (1995)
   PUBMED   7769120
REFERENCE   8  (bases 1 to 7631)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 7631)
  AUTHORS   Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E.
  TITLE     Cloning, bacterial expression, purification, and characterization
            of the cytoplasmic domain of rat LAR, a receptor-like protein
            tyrosine phosphatase
  JOURNAL   J Biol Chem 266 (29), 19688-19696 (1991)
   PUBMED   1918076
REFERENCE   10 (bases 1 to 7631)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19842.1,
                                           SRR26643299.23919.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  137109266-137109453 c
            189-268             JAXUCZ010000005.1  137102816-137102895 c
            269-403             JAXUCZ010000005.1  137095316-137095450 c
            404-549             JAXUCZ010000005.1  137087255-137087400 c
            550-691             JAXUCZ010000005.1  137086942-137087083 c
            692-880             JAXUCZ010000005.1  137074901-137075089 c
            881-991             JAXUCZ010000005.1  137066584-137066694 c
            992-1261            JAXUCZ010000005.1  137056469-137056738 c
            1262-1843           JAXUCZ010000005.1  137054602-137055183 c
            1844-1980           JAXUCZ010000005.1  137054243-137054379 c
            1981-2125           JAXUCZ010000005.1  137053623-137053767 c
            2126-2431           JAXUCZ010000005.1  137049945-137050250 c
            2432-2625           JAXUCZ010000005.1  137049152-137049345 c
            2626-2652           JAXUCZ010000005.1  137046437-137046463 c
            2653-2770           JAXUCZ010000005.1  137045007-137045124 c
            2771-3349           JAXUCZ010000005.1  137044353-137044931 c
            3350-3447           JAXUCZ010000005.1  137043586-137043683 c
            3448-3701           JAXUCZ010000005.1  137043147-137043400 c
            3702-3795           JAXUCZ010000005.1  137042968-137043061 c
            3796-4014           JAXUCZ010000005.1  137042165-137042383 c
            4015-4169           JAXUCZ010000005.1  137041639-137041793 c
            4170-4285           JAXUCZ010000005.1  137039093-137039208 c
            4286-4383           JAXUCZ010000005.1  137035917-137036014 c
            4384-4507           JAXUCZ010000005.1  137032859-137032982 c
            4508-4683           JAXUCZ010000005.1  137032561-137032736 c
            4684-4803           JAXUCZ010000005.1  137031787-137031906 c
            4804-4958           JAXUCZ010000005.1  137031401-137031555 c
            4959-5244           JAXUCZ010000005.1  137031039-137031324 c
            5245-5423           JAXUCZ010000005.1  137030760-137030938 c
            5424-5550           JAXUCZ010000005.1  137030412-137030538 c
            5551-5676           JAXUCZ010000005.1  137030057-137030182 c
            5677-5831           JAXUCZ010000005.1  137029744-137029898 c
            5832-5967           JAXUCZ010000005.1  137029514-137029649 c
            5968-7631           JAXUCZ010000005.1  137027376-137029039 c
FEATURES             Location/Qualifiers
     source          1..7631
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7631
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="protein tyrosine phosphatase, receptor type, F"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
     exon            1..188
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="upstream in-frame stop codon"
     exon            189..268
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..403
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..6036
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor-type tyrosine-protein phosphatase F;
                     leukocyte antigen-related (LAR) PTP receptor; leukocyte
                     common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     isoform 2 precursor"
                     /protein_id="NP_001423832.1"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
                     /translation="MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSS
                     YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVR
                     VSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQ
                     IRGYQVTYVRLENGEPRGQPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSITVA
                     AYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQ
                     YRRADEARPNTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDA
                     PSGFPQNLRVTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVH
                     LTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAMKTSVLL
                     SWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQ
                     HLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNL
                     LAPRWSTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKK
                     NYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEML
                     WVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
                     YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPK
                     NRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWR
                     MVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFA
                     LHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGV
                     GRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMC
                     GHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKN
                     RLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRM
                     LWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV
                     TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAG
                     VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
                     SFDHYAT"
     sig_peptide     313..399
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..663
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1060..1062
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1197
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    2086..3489
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2086..3489
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2389..2451
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2473..2475
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3160..3162
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3208..3210
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    4102..4164
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     transmembrane region"
     misc_feature    4225..4227
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10586; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); phosphorylation site"
     misc_feature    4315..5142
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    4315..5142
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    5146..6018
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     misc_feature    5146..6018
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     exon            404..549
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            550..691
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            692..880
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            881..991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1261
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1843
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1980
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2431
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2625
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2652
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2770
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..3349
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3447
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3701
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3795
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..4014
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4169
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4285
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..4383
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4507
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4683
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4803
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4958
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4959..5244
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5423
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5424..5550
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..5676
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5677..5831
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5832..5967
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5968..7631
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcggtg gcggcggcgg cagaggcggc ggctccggct ccagctccgg ctccggctcc
       61 tgttagggcg gcggtggagg tggcggtggc ggtggcggga gcgggcgacg gcggcagcgg
      121 cggactgaga acggcggcct cagcggcgcg aggcggggac atgcagaccg acggcccccg
      181 gagaggcgga aggagcggag gccctggtgc cctgccctca gtgctgactg cccagcgaga
      241 gtgactggta taaacaagaa gagaccgggt gattgtcttg ggctgtggct ggctgtggag
      301 ctagaaccct ggatggcccc cgagccagcg ccagggagga ggatggtgcc ccttgtgcct
      361 gccctcgtga tgctgggttt gatggcaggt gctcatggcg acagcaaacc tgtctttgtt
      421 aaggtccccg aggaccagat cgggctgtcg ggaggggtgg cctccttcgt gtgccaagcc
      481 acaggggaac ccaagcctcg aatcacatgg atgaagaagg gaaagaaagt cagctcccag
      541 cgctttgagg taattgagtt tgacgacgga gcagggtcag tgctgcggat ccagccatta
      601 cgagtgcagc gagacgaagc catctatgag tgcacggcca cgaacagtct cggcgagatc
      661 aacacaagtg ccaagctgtc agtacttgaa gaggaccagc tgccgtctgg gttcccgact
      721 atcgacatgg gacctcaact gaaggtggtg gagaaggctc gcactgccac catgctgtgt
      781 gcagctggtg gaaatccaga ccctgagatc tcttggttca aagacttcct tcctgtggac
      841 cctgcttcaa gcaacggtcg tatcaagcag ctgcgttcag gtgcattgca gattgagagc
      901 agcgaggagt ctgaccaagg caagtacgag tgtgtggcaa ccaactcggc aggcacacgc
      961 tactcggccc ccgccaacct gtatgtgcga gtgcgccgcg tggctcctcg tttctccatc
     1021 cctcccagca gccaagaggt aatgccgggc ggcaacgtga acctcacgtg tgtggcagtg
     1081 ggagcaccca tgccgtatgt gaagtggatg atgggcgccg aggaacttac caaagaggac
     1141 gagatgccag ttggccgcaa tgtgctggag ctcagcaatg tcatgcggtc tgccaactat
     1201 acctgtgtgg ccatctcttc actgggcatg atagaggcca cagcccaggt cacagtaaaa
     1261 gctctgccaa agcctccaat tgatcttgtg gtgacagaga caactgccac cagtgttacc
     1321 ctgacatggg actctggaaa taccgagcct gtgtctttct acggcatcca gtaccgtgca
     1381 gctggcacag atggcccctt ccaggaagtg gatggtgtgg ccagcacccg atacagcatt
     1441 ggtggcctca gccctttttc agaatatgcc ttccgtgtgt tggctgttaa cagcattggg
     1501 cgaggaccac ccagtgaggc agtgcgagcg cgcacgggtg agcaggcacc ctccagccct
     1561 ccacgccgtg tgcaggcccg aatgctgagc gccagcacca tgctggtaca gtgggaaccc
     1621 cctgaagagc ccaatggcct ggtacgggga tatcgagtct actacacccc agactctcga
     1681 cgccccttga gcgcctggca caagcataac accgacgcag gactccttac caccgtgggc
     1741 agcctgctac ctggcatcac ctacagcctc cgcgtcctgg cctttactgc cgtgggcgac
     1801 ggccctccca gccccaccat ccaagtcaag acacagcagg gagtgcctgc acagcctgca
     1861 gacttccagg ccaaagccga gtcggacacc aggatccagc tatcatggct gctgcccccg
     1921 caggagcgga tcatcaagta tgagctggtg tactgggcag cagaggatga aggccagcag
     1981 cacaaggtga ccttcgaccc cacctcctcc tacactctgg aggacctgaa gcctgacaca
     2041 ctgtaccact tccagctggc tgctcgctca gatttggggg tgggcgtctt cactcccacc
     2101 gtagaggccc gtacagcaca gtccacccca tccgcccctc cccagaaggt gacatgtgtg
     2161 agcacgggct ccaccacggt ccgggtaagt tgggttccac cgccggctga cagccgcaac
     2221 ggcattatca cccagtactc cgtggcctat gaggcagtgg acggcgagga ccgtaaacgg
     2281 catgtggtgg atggcatcag ccgtgagcat tccagctggg acctgttggg cctggagaag
     2341 tggacggagt accgggtgtg ggtgcgggca cacacagatg tgggccctgg ccctgagagc
     2401 agcccggtgc tggtgcgcac cgacgaggac gtgcctagcg ggccaccacg gaaggtggag
     2461 gttgagcctc tgaactccac tgctgtgcat gtctcctgga agctgcccgt ccccaacaag
     2521 cagcacggac agattcgtgg ctaccaggtc acctatgtgc ggctggagaa tggggagccc
     2581 cgaggccagc ccatcatcca ggatgtcatg ctggctgagg ctcagtggag accagaggag
     2641 tccgaggact atgaaaccac catcagcggc ctcacccccg agaccaccta ctccattact
     2701 gttgctgcct acaccactaa gggggacggt gcccgaagca agcccaaagt ggttactacc
     2761 acaggggcag tcccaggacg gcccaccatg atggtcagca ccacggccat gcacaccgcg
     2821 ctgctgcagt ggcacccacc caaggagctg cctggagagc tgctgggcta ccggctacaa
     2881 taccgtcggg ccgacgaggc gcggcccaac accatagatt ttggcaagga tgaccagcat
     2941 tttacagtca ccggtctgca caaaggggcc acctacatct tccggctggc tgccaagaac
     3001 cgggctggcc caggtgaaga gtttgagaaa gagatcacga cccccgagga tgcgcccagt
     3061 ggctttcctc aaaacctccg agtgacagga ctgaccacgt ctaccacgga actggcctgg
     3121 gacccgccgg tgctggcaga gaggaatggt cgcatcacca actataccgt ggtctaccgt
     3181 gacatcaaca gccagcatga actccagaat gtcactggtg atgtacacct tacactcttg
     3241 ggcctcaaac cggacaccac ttatgacatc aaggtccgtg cacataccag caaaggcgcc
     3301 ggcccactca gccccagcat ccagtcccag accatgccca tggagcaagt gtttgccaag
     3361 aatttccgtg tggccgctgc aatgaagaca tctgtgctgc tcagttggga ggtccccgac
     3421 tcttacaagt cagctgtacc cttcaagatc ctgtacaatg ggcagagcgt ggaggtggat
     3481 gggcactcca tgcggaagct gattgcagac ctgcaaccca acacggagta ctccttcgtc
     3541 ctgatgaacc gcggcagcag cgctgggggc ctacagcacc tggtgtccat ccgcactgcc
     3601 ccagacctcc tgcctcagaa gccactgcct gcctctgcct ttatagagga tggccgcttc
     3661 tccctctcca tgcctcaagt gcaggacccc tcgctagtca ggtggttcta cattgtggtg
     3721 gtgcccattg accgtgtggg cgggaacctg ctggcaccaa gatggagcac accagaggag
     3781 ctggagctgg acgagcttct ggaggccatc gagcagggtg aggagaaaca gcggaggcgt
     3841 cggcgccaag cagagcggct gaagccttac gtggcagctc aagtggacga gctccctgag
     3901 accttcaccc tgggggacaa gaagaactac cgtggcttct acaaccggcc cctgtctccg
     3961 gatctgagtt accagtgctt tgtgctcgcc tccctcaagg aacccatgga ccagaagcgc
     4021 tatgcctcca gcccctactc ggacgagatc gtagtccagg tgacaccagc ccagcagcag
     4081 gaggagcccg agatgctgtg ggtgacaggc cctgtcctgg cagtcattct catcatactc
     4141 attgtcatcg ctatcctcct attcaagagg aagagaacac attccccatc gtcaaaggat
     4201 gagcagtcaa tcgggctgaa ggactccctg ttggcccact cttctgaccc tgtggaaatg
     4261 cgaaggctta actaccagac cccaggtatg cgagaccacc cgcccatccc catcactgac
     4321 ctggcagaca atattgaacg tctcaaagcc aatgatgggc tcaagttctc ccaggagtat
     4381 gagtccattg accctggaca gcagttcacg tgggagaatt ccaactcaga ggtgaacaag
     4441 cccaagaacc gctatgcaaa cgtcattgcc tatgaccact ctcgagtcct cctcacctcc
     4501 attgatggtg ttcctgggag tgactacatc aatgccaact acattgatgg ctaccgaaag
     4561 cagaatgcct acatcgccac acagggtccg ctgcctgaga ccatgggtga tttctggagg
     4621 atggtgtggg aacagcgtac agccacagtg gtcatgatga ccaggctaga ggagaaatcc
     4681 cgggtgaagt gtgatcagta ttggccagcc cgtggcactg agacctatgg cctcattcag
     4741 gtgaccctgg tggacactgt ggagttggcc acgtacacca tgcgcacctt cgcactccat
     4801 aagagcggct ccagtgagaa gcgtgagctg cgtcagttcc agttcatggc ctggccagac
     4861 catggggttc ctgagtaccc cactcccatc ttggccttcc tgagacgggt caaggcctgt
     4921 aacccgctag atgcaggacc catggtggtg cattgcagtg ctggtgtggg ccgcacgggc
     4981 tgcttcattg tcatcgacgc aatgctggag cgtatgaagc acgagaagac agttgacatc
     5041 tatggccacg tgacgtgcat gcgctcgcaa aggaactaca tggtgcagac agaggaccag
     5101 tatgtgttca tccacgaggc actgttagag gctgccatgt gcggacacac tgaggtgctt
     5161 gctcgaaacc tctatgccca catccagaag ctaggccaag tgcctcccgg ggagagtgtc
     5221 actgccatgg agcttgagtt caagttgctg gccaactcca aggcccacac gtctcgcttc
     5281 attagtgcca acctgccctg caacaagttc aagaaccgcc tggtgaacat catgccctat
     5341 gagctgactc gagtgtgcct gcaacccatc cgtggtgtgg agggctctga ctacatcaat
     5401 gccagctttc tagatggcta cagacagcag aaggcctaca tagctacaca ggggcctctg
     5461 gccgagagca ccgaggactt ctggcgcatg ttatgggagc acaattccac catcatcgtc
     5521 atgctgacga agcttcggga gatgggcagg gagaaatgtc accagtactg gccagcagag
     5581 cgctctgctc gctatcaata ctttgtcgtt gacccgatgg ctgagtacaa catgccccag
     5641 tatatcctgc gtgaattcaa agtcacagat gcccgggatg ggcagtcaag gacaatccga
     5701 cagttccagt ttacagactg gccagagcaa ggagtaccca agacggggga aggcttcatc
     5761 gacttcatcg ggcaggtgca caagacaaag gagcagtttg gacaggatgg gcccatcaca
     5821 gtacactgca gtgctggtgt gggccgcaca ggggtgttta tcaccctgag cattgtcctg
     5881 gagcgcatgc ggtacgaggg cgtggttgac atgttccaga ccgtgaagac cctccgcaca
     5941 cagcgccctg caatggtgca gacagaggac caataccagc tgtgctaccg tgcggccctg
     6001 gaatacctcg gcagctttga tcactatgca acgtaactac tgctcccctc tcctccgccg
     6061 ctcccctgag gggctccgga ggggacccag ctcctctgag ccataccgac catcgtccag
     6121 ccctcctgca cggatgctgt tgccggcaga gcacagccca ctgggatcac agcatttcgg
     6181 gaacattgcc acaccagtca gagagcccag aacacctggg caagtaggcg gactggcagc
     6241 ctggctctgg gccctcgtcc accgggccca agtggagccc tgcttcaagc tctctgttca
     6301 gctccgcgat tctcatgctt ctcatggggt gggaaagggg gcagagcccc ccacgtttta
     6361 tacatttagg cggggtagac tgcggggtcc tagcctcttc ctccgacttt ccttttgcag
     6421 gtctttcact acagattggg ctgctgtggg agttgggact tacttgtttt cctttttgag
     6481 ttcacgttgg atccttgtac aacttctgcg gaaggacaca gtacacgctt tccttcctcg
     6541 agcagagcta gggccctacc tgagcaagtc ggctgtggcc cgggaggcag ctgagactcc
     6601 tgctgtcctc cagcctttca gaggagatcc tattccagcc aaatgcaggg aaacacttta
     6661 ttttgtttta ggttttgttt ttccttgaga gccttttttt aggccccaca gacagtggtg
     6721 ggcggggagg cgataggaaa cacatcccca gtgtgcattt aacattcata gcctacaacc
     6781 acagacgtgt ctggggggag cctggcaagg cgttcctcgt caccatcgtg tttgcaaagg
     6841 ttcaaaaaag caaaaattaa aaaaaaaaaa cataaaaata ttttttttta aaaaaaagaa
     6901 ataaagattc atcccctggc ctctccttct gctccgaagt gggaggcaac tcaatgtgcc
     6961 tggggctcgt tgtgggccca cagagtcttg ctgtcatccc cagcggtgca gtgtggcagg
     7021 tgtttgtaag ctgtgggttc tggccacctc ggtaactgaa tggcacaggt gagggcctgt
     7081 gccacgcccc acacacctca gggccaagcg ggggcgtggc cggcccttca ggtctaggcc
     7141 agtgggcctg gtagcacatg tctgtcctca gcgggacaga tgctttctct cctggtttgc
     7201 agctgtcttc aaatccccca tgactcgccc ttcccactcc ttcaagtcgc cctcacaaac
     7261 caatgtggca agactactgg acttgtatcc atggtactct actcagtcct cttatctcag
     7321 cttgctgagg ggcagggaga gggtctcttc ctctgggcag cactatctag gtagtaagtg
     7381 ggggcgggaa agggtgcata gctgttttag ccgaaggact cgatgtggac gtcctcagat
     7441 atagctaggc taagcggaga tcgacggtcc ggggttggtg gtgttggatg agacattcat
     7501 ttttaccttg tggacgctag tgctgtagag ttcactgttg tacacagtct gttttctatt
     7561 tgttaaggaa aactacagca tcattgcata cttcttgatg gtaataaatt tgaataatca
     7621 gatttcttac a
//
LOCUS       NM_001436914            7324 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 2, mRNA.
ACCESSION   NM_001436914 XM_008763550
VERSION     NM_001436914.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7324)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7324)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7324)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7324)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7324)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7324)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_008763550.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2692079.1,
                                           SRR26360172.2446015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000005.1  31992696-31992822
            128-297             JAXUCZ010000005.1  32013271-32013440
            298-435             JAXUCZ010000005.1  32078977-32079114
            436-677             JAXUCZ010000005.1  32081132-32081373
            678-767             JAXUCZ010000005.1  32085402-32085491
            768-949             JAXUCZ010000005.1  32089757-32089938
            950-1200            JAXUCZ010000005.1  32102023-32102273
            1201-1286           JAXUCZ010000005.1  32107640-32107725
            1287-1488           JAXUCZ010000005.1  32108284-32108485
            1489-1557           JAXUCZ010000005.1  32117199-32117267
            1558-1748           JAXUCZ010000005.1  32122846-32123036
            1749-7324           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7324
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..127
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..297
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    189..191
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="upstream in-frame stop codon"
     CDS             210..2024
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform a is encoded by transcript variant 2;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform a"
                     /protein_id="NP_001423843.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MISIKRNTWRALSVVIGDCRKKANFEYCQDRTEKHSTMPDSPVD
                     VKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPS
                     SSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTL
                     TIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLL
                     LDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRY
                     SPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHG
                     TRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYW
                     IRRYSDAEDLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAE
                     EAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQ
                     EDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAV
                     SSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR"
     misc_feature    573..842
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    573..842
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1218..1418
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1218..1418
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1536..>1700
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1536..>1700
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1752..1862
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1752..1862
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            298..435
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..677
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..767
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..949
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1200
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1286
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1488
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1557
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1748
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..7324
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcacacac aatgtgccat ccccaccagc cctttacttc tgataagctc cgatgtgtgt
       61 ttaatgaata caaagcggcg gtgtgggggc cgcgcggccg gccgcctcgc gcgctcgccg
      121 ccggaagaaa agattgatct gtgggctggt gaacttatct gggtcccagt ccgagcagca
      181 gaggaagtta gcacagcgct tgctggagaa tgatatctat caaaagaaac acttggagag
      241 cactgagtgt agtgataggt gactgccgga aaaaggcgaa ctttgaatat tgtcaagatc
      301 gtaccgagaa gcactccacg atgccagact cacctgtgga tgtgaagacg cagtctaggc
      361 tgactccccc agcaatgccg cctcctccga ccactcaagg agccccgaga accagttcgt
      421 ttacgccaac gacattaacg aatggcacca gccattcacc cacggccttg aatggcgccc
      481 cctcaccgcc taatggcttt agcaacgggc cttcctcttc ctcttcctct tctctggcta
      541 atcaacagct gcccccagcc tgtggtgcta gacaactgag caagctgaag cgatttctta
      601 ctaccctgca gcagtttggc aatgacattt caccagagat tggagaaaga gttcgcactc
      661 ttgtactagg actggtgaac tctactttga caattgaaga atttcattcc aaacttcaag
      721 aagctactaa cttcccactg agaccttttg tcatcccgtt tttgaaggcc aacctgcccc
      781 tgctacagcg tgaactcctc cactgcgcaa ggctagccaa acagaaccct gcccagtacc
      841 tcgctcagca cgaacagctg cttctggatg ccagcaccac ctcccctgtc gactcctcag
      901 agctgcttct cgatgtgaac gaaaacggga agaggcgaac tccagacaga accaaagaaa
      961 atggctttga cagagagcct ttgcactcag aacatccaag caagcgacca tgcactatta
     1021 gcccaggcca gcggtacagt ccaaataatg gcttatccta ccagccaaat ggcctgcctc
     1081 accccacccc acctccacct cagcattacc gtttggatga tatggccatt gcccaccact
     1141 acagggactc ctatcgacac cccagccaca gggacctcag ggacagaaat agacctatgg
     1201 ggttacatgg cacacgtcaa gaagaaatga ttgaccacag actaacagac agagaatggg
     1261 cagaagagtg gaagcatctc gatcatctgt taaactgcat aatggacatg gtagagaaga
     1321 cgaggcgatc cctcactgta ctaagacgat gtcaggaagc agaccgggaa gaactgaatt
     1381 actggatccg gaggtacagt gatgctgagg acttgaaaaa gggcggcagc ggtagcagca
     1441 gccactccag gcaacagagc cccgtcaatc cggacccagt cgcattagat gcacatcggg
     1501 aattccttca caggcctgcg tctggatacg tgccagagga gatctggaag aaagctgagg
     1561 aggctgtgaa tgaggtgaag cgacaggcaa tgacggagct gcagaaagcc gtgtctgaag
     1621 ccgagaggaa agcccatgac atgatcacca cagagcgagc caaaatggaa cgcacggtgg
     1681 ctgaagccaa gcggcaggcc gcagaggatg ctctggcagt catcaaccag caggaagact
     1741 ccagtgagag ttgctggaac tgtggccgga aagcaagtga gacctgcagc ggctgtaaca
     1801 cggcccgata ctgtggctct ttttgccagc ataaagactg ggagaagcat caccacatct
     1861 gtggacagac cctgcaggcc ccacagcagg gagaaacgcc tgctgtcagc tcctcagtca
     1921 cgcccagcag tggggctggg agcccaatgg acacaccacc agcagccact ccgaggtcta
     1981 ccacccccgg aaccccctcc accatagaga cgacgcctcg ctagacctaa actcagactg
     2041 tcagaggaaa gacaccacaa ccaacacgaa agcaattcct catcctcaga tgctcaaagt
     2101 cccttttctg tttgtttgtt tatagatgaa ctatctatct tatttcagta cttcggcaag
     2161 agagaaccta actgtatctt tgaggcgata gtaaaacaca gaggccagta acgggtcgta
     2221 atgacttact gtggaaaaca aagatatctt ttctttagag aactgaaaag agaggaaaga
     2281 atataacgtg aaatgctaga tttgacctcc tccctgttat tttcaagtag ctgggatttt
     2341 aaactagatg acctcattaa ccaatgcttt accaaacagc aaaccaagag attgctaatt
     2401 gctgttgaaa gcaaaaatgc taatattaaa agtcacagtg ttctttatat acaataatgg
     2461 aaagaaaaaa aaaaaagagg caattcctca agggcacgag cgttggatac agcagtagac
     2521 attttaacaa gaagatgaat ggcgtctgtg ggttgctaac tgaactttga agaccggctg
     2581 caaaacgcac agatgtgcag cagattggaa ggagacacag atgttcgttt tttttccccc
     2641 gtttctgaaa aagaaataat aatatccagg tcaacagaat gaaaaatgaa agatgatttc
     2701 cagtggggtg tatgactaca gcagcaagaa aaaaaaaatt gccataatac aaaggctcct
     2761 ttttatatca cacacacaca cacacacaca cacacacaca cacacacaca cacacacact
     2821 cactctctct ctccctctct ctctctctta agagactcag cctgcagtta attagcattc
     2881 tggcagcttc caagtcagcc agctgcccta aataaccctt caacgtttct tcacttttgc
     2941 aaggttccac agagtaagac attgaatcta ttccagctta ttcattttat atcgaaaaac
     3001 caattttttt aaaaaaaaaa atggcggctt cagctccagc ccctttccaa aatttttcaa
     3061 ccccaccctg tttgggtttt taattaaaat ctagtagttc tcttggtatt aaaacacttc
     3121 tgtcctgtga ggttttccca atggtgtttt tcttgtaaat gtgttggaca aatgtgaaga
     3181 tgcgttgtag ttgatccata tgcccacatt tagtctcttt attcctagtt ggtgagagaa
     3241 accagtatct ttctatgctg cttttatatc tgtatgtatt agtgatattt ctctagtagt
     3301 taaaaaaaaa aaatgaaaag aaaagaaaaa aaaaaaccac actttttttg gttgtcctca
     3361 agaaaagaag aaaagaaaag aaaagaaaaa gctatctttt ggagctgcta actcactctc
     3421 ttataggatt tttttcctgg aaaccagcat gcttcatgga atgctagcac atggatgttt
     3481 ttaagaggga tgtacataaa tgtattttgc actgtcacaa tgactcccta ggcatgcttt
     3541 ttttttttca aaccaacttt ttaaatatgc tagagccatt tcaccaattt tagctgtagc
     3601 atagagtagt agtggaattt ttcttttatc ctttttttta tgaaaaaaaa aattattagg
     3661 gactttttaa aaaaaaataa aataagatat cctactttaa aaaaaaagga cagtgcatgc
     3721 atattgctgt aaggttgttt aagtatttct aattttacaa aaaaaaaatg aaaaaaaaaa
     3781 tcattagctc tccaaatgct gaggtgtaga cggacagctt tagccctgct gagtgccagg
     3841 ttatacagta ttcttacaaa agggaagtca gccaaagact gatctgatgg accaaaatcg
     3901 gaatttttga aaagcaccag taatcctttc caaatgatca gcaggttaaa catgttcagt
     3961 gtgactccat taacccttcg ttgtccaggg tccagaccag aactacttgt tagttttgaa
     4021 acacattatt agcccaggat gtggttgtgt gctttaagag tcggcagtgc tgcaggctgt
     4081 gtagacaacc aaagttgaaa ggctgggaag acacttttcc acatacacat acaccaggca
     4141 tttctttaca aaattgagta caatccatta gcttgtggga ggggggagcg ggtaatgtag
     4201 cccttggata cagttttaag tggttgtgtt ttaagttttc tgcatagatg caatcctcac
     4261 gggattgctt catgtctcgc aaatctaagg tttccttaaa ccatttcccc tgtattttca
     4321 tataccagtc ggttttgatt ttgtcccggt agtgttgtgt tcttttctct tgtcgtcgtc
     4381 gtcgttgttt tcaatggcct tttagtttag gaagttctga tgagcgaatc aatgcatcta
     4441 tctatctgca tgttggaagt ccatctgcca gcacacccgc taaggcaaag agaagcgcat
     4501 aaccaggctg cgaatgggtt ctattttacc atggtgctcc cagaatcctt tgacctcatt
     4561 ctgctttcta gtctgcttgt gacactggac agtcctttct tagagctatt atatgttcta
     4621 ggctacgaag ggttaaataa tcccaaaaaa aataacaaaa aaaaatgagg tatgtcatac
     4681 cctcgcgtct cgatctcaag aagctgtgat gtatgtggaa cagcactgtt attctgaaca
     4741 ctagtgtgta aaataaggat tagtacagta cgtctcattc cttttttaat tcagggcacc
     4801 ctgagtgaaa accaatacaa aaaaaaaaaa aaatccctaa ctctgagctc tgtctctaat
     4861 tcctcttcct ccttcccctc ttcctcctcc tcttcctcta ctcctgtttt gctacattct
     4921 cctcagtggc aaaaagtttc actctacctc tgacagcatg tatattgcac cagtcgctaa
     4981 cgaaaactgg tctagtcaaa ccaaatgggc acaaaagaac caggatacca aaagttaagc
     5041 tcatacagct gcgaaccata tcacttcttg gtaacaatgc agacctcata aacctaaaaa
     5101 aaaagagaaa gaaaagaaaa cttttgttac tttccttttt tgcttgtcac ttatatacag
     5161 gctatgtgag agtattcatt tgtaggtatt acacattaaa aaaaaaaagc tatcttcatt
     5221 ggatagaact gaatggtggt cgctgatagg aatagggcgt cctctatctc ttatctctgt
     5281 ctcttttctc tttctctttc tctgtcatga gactgtgtgt gacagggcta cctgtctttt
     5341 taatttgttt tctgaacttt ttttttttaa tgtgtaggtg catgtcttgg ggatttaaaa
     5401 atttcaaggc tggtttactt atgcaaagca tgcctatgtc tggaatactt agggaaagaa
     5461 agtgactcca tgttgtccga attcctcaag ggacagaaaa acaaattgga gactgttgaa
     5521 atgcagattt gaagtaattt tatttttaat tattttgggt tctgcgacat tattgtgaaa
     5581 aattaaagtc gttgtgcaat acttaattca gacacgtgcc acaagttaac ggtagactaa
     5641 cactgggggg cgggggctag gcatcacgct tttgtctgca tactcttgag cttttaagtc
     5701 tactatgtct gaactgtggt ttcttgttta tccttttttg ttttttcctt agttggactg
     5761 taatgtatgg tctgtcaacc tgtgaatctt taaagtatga ttcaggtatt gttgtactct
     5821 ttaccgtgta ataaaaatgc ttaaaaaaaa aagtcagtag tccgtctccc ttatctttac
     5881 tgtgtgcccg ccaaggctac cactcaggaa cctcattctt gaagggcagt tcttcatgga
     5941 gcatgcccag agtctagtca gctacagagt atgtctctaa cgtgttaatt cgcccacgag
     6001 tgatgaggga gaaggagaga acacagagga catttctgag gtcatagtag tccaatatag
     6061 aaggatactc caagtcctcc ataagaaagg atagcttatg ctaggggtca ccgtctccag
     6121 aaaggtccaa ttgccatctt tttaaactct ggcttgcagc atgtttcttt cattctcagc
     6181 tgcaggatgt acccactaag gcagatctct tcctccatct gtcctggatc ctcaccgcct
     6241 ttaattagaa gttgccagca tgttcacact tggttttgta catttgtaaa tacacagtat
     6301 gttgtgtcca tcttgtttct gagacccatg ttgtccattt aacacgcacc agtatatttt
     6361 ttttcatgca ctagctataa aaaataactt agactttgga gaacctattg gtcatctacc
     6421 atagaaactc agtcaatttt cacgtacttt acacaacaca ttttttaatg actgtatata
     6481 ctgcattgta gcagaatttc tgatttgctt ggaagattcc cgctatggcc taaaactagc
     6541 ttaaagggat caagtgaaat gcaagaactg aatctggaga gacagagaag tcacatagac
     6601 gctgtcgagt gggaggataa cctagggcct tctcttcagt ttcctttgta cgccagctag
     6661 gcccctatgc ctgtcctgag gcctggcttc tccaaatgat gttgagaaat gcagcctatt
     6721 ttacagagtg aggaagggag cggggaaggg agggagggag gagggagaaa gagagagaga
     6781 gagagagaga gagagagaga gagtttaaaa gcatagctag tgcgtatctt attcctacaa
     6841 aataaacagg ctgagtattt agttttgtag ttaatttttc ccctcactcc aaagcctgac
     6901 cagcgtggct caacttgctt ttcttatttg tacagataca ttttcttttt cttttcaaag
     6961 tggaacagac cagaaaccag aagacatgga ggacataact gagatgcctt gaagtagccc
     7021 ctttataagc tgtccttgaa aaacagctct gtgacctatt tgtatgactg gattgctaga
     7081 caaatgagta atgagtttag tttagaggaa gaatgtgaac aaaatcagct tctgggtggt
     7141 aagcaccatt ttttaaaaga atgtaattga tgtatttgat aatataaaaa tgatgtttgc
     7201 catgaaagaa cactaagtta tttccccaga ttggaagggg aagaaatgat caaagaggtg
     7261 cttttctgta tgggtattta tatctttatt tcaaggtgaa tgaataaagt tgtacttgcc
     7321 taaa
//
LOCUS       NM_001436878            2827 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 5, mRNA.
ACCESSION   NM_001436878 XM_017600169
VERSION     NM_001436878.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017600169.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.162120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1831           JAXUCZ010000016.1  17498298-17498468
            1832-1955           JAXUCZ010000016.1  17503674-17503797
            1956-2006           JAXUCZ010000016.1  17504488-17504538
            2007-2143           JAXUCZ010000016.1  17505392-17505528
            2144-2204           JAXUCZ010000016.1  17508313-17508373
            2205-2287           JAXUCZ010000016.1  17509056-17509138
            2288-2827           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2827
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2431
                     /gene="Eps15l1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 5"
                     /protein_id="NP_001423807.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMVKDDPFKNKALLFSNNSQELHPDPFQA
                     EDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKK
                     QTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSA
                     EGFADFSQMSKFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALSKADMPA
                     "
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1831
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1955
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2006
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2143
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2204
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2287
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2827
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggtaaa ggatgatcct ttcaaaaaca aagccttgtt
     1861 gtttagcaac aactctcaag agctgcatcc agaccccttc caggcagagg accccttcaa
     1921 gtctgaccca tttaaaggag ctgatccctt caaaggtgac cctttccaga gtgatccctt
     1981 ctcagagcag cagacagcag ttacagaccc atttggaggg gaccctttca aagaaagtga
     2041 cccattccat agctcaacca gtgatgactt cttcaagaaa cagacaaaga atgacccgtt
     2101 tacctcagac cccttcacaa agaacccttc cttaccttca aagctcgacc cattcgagtc
     2161 cagtgatccc ttctcatcct ccagcatctc ctcgaaaggt tcagatccct tcggaacact
     2221 agaccccttt ggaagcagct ccttcagcag tgccgagggt ttcgctgact tcagtcagat
     2281 gtccaagttt ggcaatgagg agcagcagct ggcctgggcc aaacgggaga gtgagaaagc
     2341 ggagcaggag cggctggcga ggcttcggcg acaggaacag gaggacctgg agctggccat
     2401 cgccctcagc aaggccgata tgccggccta ggtgacacag gggaagccgc agctgtctgt
     2461 atgtccacat catgctcaga gcgtgccccc ttcaagccaa gccatgccac agccaaggac
     2521 agctggccac agggcctcag gccacaggga ccttgttgag aggtagcaga cacagcccac
     2581 gcctgtgggt gggccaggaa ggcagccttc ggtaaaaggc ctggaacctg cctgtctctg
     2641 aggtgtcagt caggctcttc cttccaatca ttcagtgact gacggagaag gcctccagtc
     2701 tcctagctac agacaagctc caccccaacc cttcctcaca tccacaagac accctgcaca
     2761 catgatgtat gcattcgttg tataaaaatg aagtttgaat gattaatata aaatatttta
     2821 atacaaa
//
LOCUS       NM_001436935             607 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 3, mRNA.
ACCESSION   NM_001436935 XM_063287904
VERSION     NM_001436935.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287904.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.1724433.1,
                                           SRR26360172.1265873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000005.1  61741704-61741766   c
            64-131              JAXUCZ010000005.1  61741422-61741489   c
            132-191             JAXUCZ010000005.1  61741152-61741211   c
            192-289             JAXUCZ010000005.1  61738859-61738956   c
            290-422             JAXUCZ010000005.1  61737621-61737753   c
            423-607             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..607
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..63
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            64..131
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..579
                     /gene="Ccl27"
                     /note="isoform a is encoded by transcript variant 3; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform a"
                     /protein_id="NP_001423864.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSPMPPTSQR
                     LSLEPPRLPLTGWHPWNKTKEKQEALPLPSSTSCCTQLYRQPLPTRLLRRIVRVELQE
                     ADGDCHLQAVVLHLTRRSVCVHPQNRSLARWLERHGKRLQGTLPSLNPVLQKKMCPSP
                     QKQK"
     misc_feature    310..492
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    310..492
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            132..191
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            192..289
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            290..422
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            423..607
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaatc tccattcagg gcctaaacgt cccagctata ctgccgctag acccctctcc
       61 ttggaaccgt tcggagctcg agacatgtcg cgattgagga gatacgaggt ggcgctggaa
      121 gcggaggagg agatctactg gggctgcttc tacttttttc cttggctgcg aatgtggcgc
      181 agggagcgga gtccgatgcc tccaacaagc cagagactaa gtctggaacc ccccaggctc
      241 ccgctgacag gctggcatcc gtggaacaag actaaggaga agcaagaagc cttgccactg
      301 ccctccagca ctagctgctg tactcagctc tataggcaac cactcccaac cagactactg
      361 aggaggatcg tccgtgtgga gctgcaggag gctgacgggg actgccacct ccaagctgtt
      421 gtgcttcacc tgactcggcg cagtgtctgt gttcatcccc agaaccgtag cctggctcgg
      481 tggttagaac gccatgggaa aaggctccag gggaccctac ccagtttaaa tccggtacta
      541 caaaagaaaa tgtgcccgag cccccaaaag caaaagtaat aaagcaacat tagacgataa
      601 tctccaa
//
LOCUS       NM_001436905            5350 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus DEP domain containing 5, GATOR1 subcomplex
            subunit (Depdc5), transcript variant 2, mRNA.
ACCESSION   NM_001436905 XM_063273165
VERSION     NM_001436905.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5350)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   2  (bases 1 to 5350)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   3  (bases 1 to 5350)
  AUTHORS   Marsan,E., Ishida,S., Schramm,A., Weckhuysen,S., Muraca,G.,
            Lecas,S., Liang,N., Treins,C., Pende,M., Roussel,D., Le Van
            Quyen,M., Mashimo,T., Kaneko,T., Yamamoto,T., Sakuma,T., Mahon,S.,
            Miles,R., Leguern,E., Charpier,S. and Baulac,S.
  TITLE     Depdc5 knockout rat: A novel model of mTORopathy
  JOURNAL   Neurobiol Dis 89, 180-189 (2016)
   PUBMED   26873552
  REMARK    GeneRIF: DEP-domain containing 5 knockout rats exhibit multiple
            features of rodent models of mechanistic target of rapamycin
            complex 1 (mTOR) mTORopathies, and thus, stand as a relevant model
            to study their underlying pathogenic mechanisms.
REFERENCE   4  (bases 1 to 5350)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   5  (bases 1 to 5350)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   6  (bases 1 to 5350)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   7  (bases 1 to 5350)
  AUTHORS   Dibbens,L.M., de Vries,B., Donatello,S., Heron,S.E., Hodgson,B.L.,
            Chintawar,S., Crompton,D.E., Hughes,J.N., Bellows,S.T., Klein,K.M.,
            Callenbach,P.M., Corbett,M.A., Gardner,A.E., Kivity,S., Iona,X.,
            Regan,B.M., Weller,C.M., Crimmins,D., O'Brien,T.J.,
            Guerrero-Lopez,R., Mulley,J.C., Dubeau,F., Licchetta,L.,
            Bisulli,F., Cossette,P., Thomas,P.Q., Gecz,J., Serratosa,J.,
            Brouwer,O.F., Andermann,F., Andermann,E., van den Maagdenberg,A.M.,
            Pandolfo,M., Berkovic,S.F. and Scheffer,I.E.
  TITLE     Mutations in DEPDC5 cause familial focal epilepsy with variable
            foci
  JOURNAL   Nat Genet 45 (5), 546-551 (2013)
   PUBMED   23542697
REFERENCE   8  (bases 1 to 5350)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063273165.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.55086.1,
                                           SRR26360181.2667518.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000014.1  82087256-82087292   c
            38-160              JAXUCZ010000014.1  82086314-82086436   c
            161-248             JAXUCZ010000014.1  82082754-82082841   c
            249-295             JAXUCZ010000014.1  82081990-82082036   c
            296-381             JAXUCZ010000014.1  82076632-82076717   c
            382-465             JAXUCZ010000014.1  82075101-82075184   c
            466-515             JAXUCZ010000014.1  82073810-82073859   c
            516-585             JAXUCZ010000014.1  82065166-82065235   c
            586-664             JAXUCZ010000014.1  82059994-82060072   c
            665-726             JAXUCZ010000014.1  82057813-82057874   c
            727-796             JAXUCZ010000014.1  82054640-82054709   c
            797-869             JAXUCZ010000014.1  82053717-82053789   c
            870-973             JAXUCZ010000014.1  82051584-82051687   c
            974-1048            JAXUCZ010000014.1  82050570-82050644   c
            1049-1183           JAXUCZ010000014.1  82048741-82048875   c
            1184-1245           JAXUCZ010000014.1  82048313-82048374   c
            1246-1319           JAXUCZ010000014.1  82048015-82048088   c
            1320-1389           JAXUCZ010000014.1  82041033-82041102   c
            1390-1426           JAXUCZ010000014.1  82039384-82039420   c
            1427-1547           JAXUCZ010000014.1  82038588-82038708   c
            1548-1768           JAXUCZ010000014.1  82034655-82034875   c
            1769-1972           JAXUCZ010000014.1  82028524-82028727   c
            1973-2108           JAXUCZ010000014.1  82026612-82026747   c
            2109-2203           JAXUCZ010000014.1  82025608-82025702   c
            2204-2269           JAXUCZ010000014.1  82017612-82017677   c
            2270-2453           JAXUCZ010000014.1  82013892-82014075   c
            2454-2614           JAXUCZ010000014.1  82013290-82013450   c
            2615-2732           JAXUCZ010000014.1  82007658-82007775   c
            2733-2900           JAXUCZ010000014.1  82007016-82007183   c
            2901-3120           JAXUCZ010000014.1  82006023-82006242   c
            3121-3254           JAXUCZ010000014.1  82004307-82004440   c
            3255-3360           JAXUCZ010000014.1  81995949-81996054   c
            3361-3426           JAXUCZ010000014.1  81992899-81992964   c
            3427-3578           JAXUCZ010000014.1  81987025-81987176   c
            3579-3656           JAXUCZ010000014.1  81984251-81984328   c
            3657-3789           JAXUCZ010000014.1  81983350-81983482   c
            3790-3898           JAXUCZ010000014.1  81976926-81977034   c
            3899-4126           JAXUCZ010000014.1  81975276-81975503   c
            4127-4296           JAXUCZ010000014.1  81971181-81971350   c
            4297-4468           JAXUCZ010000014.1  81967616-81967787   c
            4469-4529           JAXUCZ010000014.1  81964695-81964755   c
            4530-4612           JAXUCZ010000014.1  81960418-81960500   c
            4613-5350           JAXUCZ010000014.1  81959560-81960297   c
FEATURES             Location/Qualifiers
     source          1..5350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5350
                     /gene="Depdc5"
                     /note="DEP domain containing 5, GATOR1 subcomplex subunit"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
     exon            1..37
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            38..160
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..4905
                     /gene="Depdc5"
                     /note="isoform 2 is encoded by transcript variant 2; DEP
                     domain-containing protein 5; GATOR complex protein DEPDC5;
                     GATOR1 complex protein DEPDC5"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform 2"
                     /protein_id="NP_001423834.1"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
                     /translation="MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHP
                     NDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
                     TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEET
                     RVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTV
                     VLFSRTFYDAKSIDEFPEVNRASIQQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKK
                     LFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSV
                     VITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPRDSR
                     LGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSATEKTKNGRDTSLGAPKESE
                     NTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHNRKSASSCDVSSSPSLPS
                     RALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIEPPQ
                     RDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVG
                     PSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDSMSL
                     NFSGTEELSVSLLSNSGTGMNPRNQNKDSLEDGVSTSPDPILTLSAPPVVPGFCCTVG
                     VDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVF
                     EEFICQRLMQGYQIIVQPKTQKPSTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMG
                     RTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFCHERLEE
                     YKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKP
                     RADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLESTGP
                     PVGKKGTSALSALLEMEASQKSLGEQQTSVHGKSSTQPAENSSVAMTPTYVDSPRKDG
                     AFFMEFVRSPRTASSAFYPQASVDQTAPLVLDSTSLGVSTCQSVDRGNNQTFGNSQNI
                     EQAFPSTGSGDGSSQQHIASSLTSSSTLVEILEAMKHPSTGVQLLSEQKGLSPCCFIS
                     AEVVHWLMNNVEGVQTQAMGIDIMQKMLEEQLIAHASGEAWRTFVYGFYFYKIVTDRE
                     PERVAMQQPSAPWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASY
                     ASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLN
                     AAFEIKLHWMAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQL
                     FIPLNLGCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAE
                     NKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLT
                     KTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTNCLEKMHASAP"
     misc_feature    403..1245
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    403..1245
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    3628..3873
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3628..3873
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3925..4848
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     misc_feature    3925..4848
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     exon            161..248
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            249..295
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            296..381
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..465
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            466..515
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..585
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            586..664
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            665..726
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            727..796
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..869
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            870..973
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1048
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1183
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1245
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1319
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1389
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1426
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1547
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1768
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1972
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2108
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2203
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2269
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2453
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2614
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2732
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2900
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3120
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3254
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3360
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3426
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3578
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3656
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3789
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3898
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4126
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4296
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4468
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4469..4529
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4612
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4613..5350
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcggggc ggagcctccg gagcggcgcg ggctcagtag caggaaggca agatgacttc
       61 cctgctccaa gatcggaaca gctgaagaaa ccacaagaca aaatgagaac cacaaaggtc
      121 tacaaacttg tcatccacaa gaagggcttt gggggcagtg atgatgagct ggtcgtgaac
      181 cctaaagtct ttcctcacat caaacttgga gacattgtgg agatcgctca ccccaatgat
      241 gaatacagtc ctttgctttt gcaagtcaag tctcttaagg aagatttaca gaaagaaact
      301 atcagtgtgg accagactgt gacacaagta ttccggctaa gaccttatca agatgtctat
      361 gtaaacgttg tagaccccaa ggatgtgact cttgacctag tggaattgac ttttaaggat
      421 cagtatatag gccgggggga tatgtggcga ctaaagaaaa gtttggtgag cacctgtgcc
      481 tatatcaccc agaaagtgga atttgctggc atcagggcac aggctggtga gctgtgggtc
      541 aagaatgaga aggtcatgtg tggttacatt agtgaagaga ccagggtggt gttccgttct
      601 acgtcggcta tggtttacat atttattcag atgagctgtg aaatgtggga ttttgatatt
      661 tatggggatc tgtactttga gaaagctgtg aatggtttcc ttgccgacct gtttactaag
      721 tggaaggaga agaactgtag ccatgaagtg actgtggttc tgttttctag aactttttat
      781 gatgcaaaat ctattgatga atttcctgaa gtaaaccgag cttcaattca acaggatcat
      841 aaagggagat tctacgagga cttttacaaa gtggtggtgc agaacgagag aagggaagag
      901 tggacgtcac tccttgtgac cattaagaaa ctcttcatcc agtatccagt gttggttcga
      961 ctggaacagg cagggggctt tcctcaagga gacaattcta cctcagcaca aggaaactac
     1021 ctagaggcca tcaacttgtc attcaatgtg tttgacaagc actacatcaa ccgaaacttt
     1081 gaccgaactg ggcagatgtc cgtggtgatc acgccggggg tgggtgtctt tgaagtggac
     1141 cgcctcctca tgatcttgac caagcagcgg atgatcgata atggaattgg tgtggactta
     1201 gtgtgcatgg gagagcagcc attacacgct gtgccattat tcaagctgca caaccggagt
     1261 gtgccacggg attctcggct gggcgatgac tataatattc ctcactggat aaaccacagt
     1321 ttctacacat ccaaaagcca gctgttttgt aacagtttca ctccaaggat aaaactggca
     1381 ggaaagaagt ctgccactga gaaaaccaaa aatggccgtg atacatctct tggggctcca
     1441 aaggaatctg aaaacaccct tcccatccaa gtagattatg atgcctacga tgcccaagta
     1501 ttccggctgc ctggtccatc ccgggcccag cgactcgcca cctgcaggtc tgtgagagag
     1561 caggaaaatc acaatcgcaa aagtgccagc tcctgtgacg tctcctccag cccttccttg
     1621 ccaagccgtg cactgcccac tgaggaagtg aggagccagg cttcagacga cagctccctg
     1681 ggcaagagca ccaacatcct gatgatccct aacccccatc tgcaccagta tgaagtcagc
     1741 agctcactgg gctacaccag cacccgagat gtcctggaga acatgataga accaccacag
     1801 cgggactcta gtgcacctgg aaggttccac gtgggcagtg cagagtccat gctacatgtt
     1861 cgacctggag gctacacccc tcagagagca ctgattaacc ccttcgcccc ctcaagaatg
     1921 cccatgaagc tcacctccaa cagaaggcgc tggatgcata cttttcctgt aggaccatct
     1981 ggagaggcca tccagatcca tcatcaaacc cggcaaaaca tggcagagct gcagggcagc
     2041 aggcagcggg accccaccca ctcctctgca gaactgttgg agctggcata tcatgaagcc
     2101 gcaggaaggc acagcacttc ccgacagcct ggtgacagca tgtccttgaa cttcagtgga
     2161 acggaagagc tttctgtcag cctgcttagc aacagcggca caggtatgaa tcctaggaac
     2221 cagaataagg actctctaga ggatggtgtt tctacctctc cagacccaat tctgacactg
     2281 tctgctcccc ctgtagtgcc aggcttctgt tgcacagttg gagtggattg gaagtctctt
     2341 actactcctg catgccttcc cctcaccact gactacttcc cggaccgtca gggcctgcag
     2401 aatgactaca cagagggctg ctatgatctc ctcccagaag cagacatgga caggagggac
     2461 gaggagggcg ttcaaatgac agcccagcaa gtgtttgaag agttcatctg ccagcgtctc
     2521 atgcagggtt accaaatcat agtacagcca aagacccaga agcccagcac tacagtccca
     2581 cccccgctga gcagtagccc actctatagc agaggccttg tgtcccgaaa ccgccctgaa
     2641 gaggagggcc agtattggct gagtatgggc agaaccttcc ataaggtgac acttaaggac
     2701 aagatgatca cagtgactcg ttaccttccc aagtaccctt atgaatctgc ccagatccat
     2761 tacacctaca gcctctgccc ttcccactct gactcagagt ttgtctcctg ttgggtggaa
     2821 ttctgccatg aacggctaga ggaatacaag tggaattact tagatcagta catttgttct
     2881 gccggctccg aagatttcag cttaatcgag tctctgaagt tctggagaac ccgatttcta
     2941 ctactgccag cctgtgtcac tgccaccaag cgcatcacag aaggggaagt gcactgtgac
     3001 atctacgggg acaaaccccg tgcagatgaa gatgagtggc agcttctaga tggctttatt
     3061 cgctttgtag agggcttgaa ccgcatccgc aggcgccacc ggtcagaccg catgattcgg
     3121 aaagggactg ccatgaaagg cttgcagatg accgggccca tctccgcaca ctctctcgag
     3181 tcaacgggcc ccccagtcgg gaagaaagga acctcagctc tgtctgccct gctggagatg
     3241 gaggctagtc agaagagcct aggagaacag cagacaagtg tgcatgggaa aagctctact
     3301 cagccagctg agaacagcag tgttgccatg actcccacct atgtggacag cccacgcaag
     3361 gacggggcct tctttatgga gtttgtccgc agcccacgca cagcatcatc tgccttctac
     3421 cctcaggcat ctgtggacca aacagctcct ctggtgttgg acagcaccag tttaggggtc
     3481 agcacgtgcc agtccgtgga tagaggcaat aaccagacct ttgggaactc ccagaacata
     3541 gaacaggcct ttccctctac aggctctgga gacggcagct ctcagcagca catagccagc
     3601 tctctgacat cgtcctctac cctggtggag atcctggaag ccatgaagca tccctcgaca
     3661 ggagtccagc tgctgtctga gcagaagggc ctttcgccgt gctgcttcat cagtgcggag
     3721 gtcgtacact ggctgatgaa caatgtggag ggggtccaga cgcaggcgat gggcatcgac
     3781 atcatgcaga aaatgctgga agagcagctc atagcgcatg catctggaga agcatggcga
     3841 accttcgtct acggcttcta tttctacaag atagtcacgg acagagagcc cgaacgagtg
     3901 gctatgcagc agccctctgc cccatggcac acagcaggag tggatgactt tgccagcttc
     3961 caacgcaagt ggtttgaggt ggcctttgtg gcagaagagc ttgtgcactc cgagattcct
     4021 gccttcctcc tgccctggct acctagccgg ccagcctctt acgcaagcag gcacagctcc
     4081 tttagccgaa gttttggagg acggagccag gcagctgcac tgttagctgc cactgtccca
     4141 gagcagagga ctgtgaccct ggatgtcgat gtgaacaacc gaacggaccg gctggagtgg
     4201 tgcagctgtt actaccacgg aaacttctct ctcaacgcag cctttgaaat caagctacac
     4261 tggatggcag tgactgccac agtgctgttt gagatggtcc aaggttggca tcgaaaagct
     4321 acatcctgcg gcttcttgtt agtcccggtt ttggagggtc cttttgcact gcccagttac
     4381 ctgtacggtg accccttgag ggcccagctc ttcatcccgc tcaacctcgg ctgcttgctc
     4441 aaggagggca gcgagcacct gttcgatagc tttgaaccag agacatattg ggatcgaatg
     4501 caccttttcc aggaagccat tgcacacagg tttggatttg tgcaagataa atattctgcc
     4561 tccgcgttta acttccctgc tgagaataaa ccacagtata tccacgtcac aggaacagtg
     4621 tttcttcagc tgccgtactc caaacgcaag ttttctgggc agcagcggcg gcgacggaac
     4681 tctaccagct ccaccaacca aaacatgttc tgtgaggagc gggttggcta caactgggcc
     4741 tataacacca tgctgaccaa gacatggcgc tctagtgcca cgggggatga gaagtttgcc
     4801 gatcggctgc tgaaggactt cacggatttc tgtatcaacc gtgacaaccg cctggtcaca
     4861 ttctggacaa actgcctgga gaagatgcac gccagcgctc cctgacgcca ggctgctcca
     4921 ttaggagagg ctgtgggtat cctggagctg gctgtccagc taggctctgg gcatcaggtg
     4981 tcaggctgct cctgtcagcg agtggggcca ctgctgatat ttggcctctt gcacaagtgt
     5041 gagtgaggag aaagactgga agcagctgct gttgctacca ccacccagat ctcgccatca
     5101 cgtgcccgag gcagggggag gcacagattg tccgtgggag ggagtcagtg tctgggaatg
     5161 gggtaggcag cttccattaa ggtccttttt cctcaccagc agtgggatat ttggaacaga
     5221 aagaacctcc tgctttctgc ccaagaatgt gtgtgtatag gataattctg tgacatagtg
     5281 taccattgcc tcataccagc tgtacatacg tgtacatagc agaagtgaat aaagcccccc
     5341 acacagtgtc
//
LOCUS       NM_001436891            3417 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 17, mRNA.
ACCESSION   NM_001436891
VERSION     NM_001436891.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3417)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50080.1,
                                           SRR26643298.70772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-3417           JAXUCZ010000016.1  17498298-17500054
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3417
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1840
                     /gene="Eps15l1"
                     /note="isoform 17 is encoded by transcript variant 17;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 17"
                     /protein_id="NP_001423820.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMVKVE"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..3417
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggtaaa ggtcgagtaa gagtctccag gtccacgtgg
     1861 gctctgctgc agctgtagat ctgcttacaa caatatctgg ctatctgcct gcgcagggcc
     1921 cagggctggt ggccaagttc ctcctgtcat ctagaaactg tgaggcccag gagttccatc
     1981 tcctcagaag tgtttctttt gggccaattg cccaaatgtg gagggcaaac ctaaccaaag
     2041 ctagtgtggt cccatgctat gggagcccgg tgctctactg atacagcctt gggtgtaaat
     2101 gtatgtcatt cacgtcaagt gattctgaga tggagaaaca ggctgcatgt gcagctccgg
     2161 tggtgagcac tgcacgctcc agttctttca ccctgcacca ctcactaagc accatagcac
     2221 atctgccctc cagatgctgt gcggtcaact gttggctggc ctctgggagg acctcagcac
     2281 tgtgtggcca cactgcatcg atgctcagcg atgtgatcct tctctaaggt tgtcagtgcc
     2341 ccttgttgca atcatcagcc ccaactcagg gaagtctgtg gttgaacctg caggtcctgg
     2401 tatctggggt attatgctac tcttaacctc ttggctgcct catcttccag ggctctgctt
     2461 tgctctagcc ctgctgcttt ctttcttcgt ccctcccctc ctgtggtcgc cacttacctt
     2521 gcactctaaa cacagccacc ttccctctct cttctctttc tttcccattc aagaactcag
     2581 gagaagcctg tgcttcccct gaaccactta ggaggtgctg tttgtacttc tgcccgtctc
     2641 tagtgtctgc ccacctggag gcctccttta ctcttaaact cataagtagg tggctcctgc
     2701 ctaccatggg catctgtcca tggacttccc atggattcct tgctttttgg cctatggcca
     2761 atgcgtgttt ccatcttaca actgcggtct ccagctccat cccatcactg tcccctgtgc
     2821 agctggctta ccagaggctc actgtgttct gggccaggga aatgctccct ctaagcctcc
     2881 ccttgtggat tgtttggtcg gtcagtcagt gggctggtct gtctgtctgc ctgtctgcct
     2941 gcctttctct ctctctctct ctctctctct ctctctctct ctctctctct ctttcttggt
     3001 ttgtctgtct gctttctttc ctcttcctcc tcttcctccc ttcccctcct cctttttctc
     3061 tttctgagac ggcatcactg tgcagcccag gctgcggtgg gactcgggag atcccagttg
     3121 cagggattaa aggtgtgtgc caggttctcc tgtagctttt atcacatcct aggctgcatc
     3181 ttagcagtgg gtgacagttt acaggtagtg tcatttctac caccgccaga gccttttgta
     3241 catggttatt tttgtccatt gtctaaccag gtagagtttg catggctaac tgtcatttgt
     3301 acagtgtaac catcagataa cctagaaact caagacttgt ttctgaagga acccacatct
     3361 tgtatttaaa aaaaaaaaaa atgggttgtt tccatttctt aataaacagt ttgaagc
//
LOCUS       NM_001436915            7594 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 3, mRNA.
ACCESSION   NM_001436915
VERSION     NM_001436915.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7594)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7594)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7594)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7594)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7594)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7594)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2232071.1,
                                           SRR26360176.736893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000005.1  31992696-31993092
            398-567             JAXUCZ010000005.1  32013271-32013440
            568-705             JAXUCZ010000005.1  32078977-32079114
            706-947             JAXUCZ010000005.1  32081132-32081373
            948-1037            JAXUCZ010000005.1  32085402-32085491
            1038-1219           JAXUCZ010000005.1  32089757-32089938
            1220-1470           JAXUCZ010000005.1  32102023-32102273
            1471-1556           JAXUCZ010000005.1  32107640-32107725
            1557-1758           JAXUCZ010000005.1  32108284-32108485
            1759-1827           JAXUCZ010000005.1  32117199-32117267
            1828-2018           JAXUCZ010000005.1  32122846-32123036
            2019-7594           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7594
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..397
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..567
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    459..461
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="upstream in-frame stop codon"
     CDS             480..2294
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform a is encoded by transcript variant 3;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform a"
                     /protein_id="NP_001423844.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MISIKRNTWRALSVVIGDCRKKANFEYCQDRTEKHSTMPDSPVD
                     VKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPS
                     SSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTL
                     TIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLL
                     LDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRY
                     SPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHG
                     TRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYW
                     IRRYSDAEDLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAE
                     EAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQ
                     EDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAV
                     SSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR"
     misc_feature    843..1112
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    843..1112
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1488..1688
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1488..1688
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1806..>1970
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1806..>1970
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    2022..2132
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    2022..2132
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            568..705
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..947
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1037
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1219
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1470
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1556
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1758
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1827
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2018
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..7594
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcacacac aatgtgccat ccccaccagc cctttacttc tgataagctc cgatgtgtgt
       61 ttaatgaata caaagcggcg gtgtgggggc cgcgcggccg gccgcctcgc gcgctcgccg
      121 ccggaaggta atctccgcgg ccgggctggg ggcggcgggg cggggcgcgg cgtgggggcg
      181 gccccccaac gatcccgagc agataagagc cagggaagtg aagatgtaac ctgttatcgg
      241 gagctcctct tagctgccag agggaattta catttaaaga ttacagaggg agagggagag
      301 gatctgcctt ttgttgtgct gggtgaggag gaggcagcgg ccctggcctc cctgctatct
      361 cccaacacct ctgctatcca gacggggact cgcggagaaa agattgatct gtgggctggt
      421 gaacttatct gggtcccagt ccgagcagca gaggaagtta gcacagcgct tgctggagaa
      481 tgatatctat caaaagaaac acttggagag cactgagtgt agtgataggt gactgccgga
      541 aaaaggcgaa ctttgaatat tgtcaagatc gtaccgagaa gcactccacg atgccagact
      601 cacctgtgga tgtgaagacg cagtctaggc tgactccccc agcaatgccg cctcctccga
      661 ccactcaagg agccccgaga accagttcgt ttacgccaac gacattaacg aatggcacca
      721 gccattcacc cacggccttg aatggcgccc cctcaccgcc taatggcttt agcaacgggc
      781 cttcctcttc ctcttcctct tctctggcta atcaacagct gcccccagcc tgtggtgcta
      841 gacaactgag caagctgaag cgatttctta ctaccctgca gcagtttggc aatgacattt
      901 caccagagat tggagaaaga gttcgcactc ttgtactagg actggtgaac tctactttga
      961 caattgaaga atttcattcc aaacttcaag aagctactaa cttcccactg agaccttttg
     1021 tcatcccgtt tttgaaggcc aacctgcccc tgctacagcg tgaactcctc cactgcgcaa
     1081 ggctagccaa acagaaccct gcccagtacc tcgctcagca cgaacagctg cttctggatg
     1141 ccagcaccac ctcccctgtc gactcctcag agctgcttct cgatgtgaac gaaaacggga
     1201 agaggcgaac tccagacaga accaaagaaa atggctttga cagagagcct ttgcactcag
     1261 aacatccaag caagcgacca tgcactatta gcccaggcca gcggtacagt ccaaataatg
     1321 gcttatccta ccagccaaat ggcctgcctc accccacccc acctccacct cagcattacc
     1381 gtttggatga tatggccatt gcccaccact acagggactc ctatcgacac cccagccaca
     1441 gggacctcag ggacagaaat agacctatgg ggttacatgg cacacgtcaa gaagaaatga
     1501 ttgaccacag actaacagac agagaatggg cagaagagtg gaagcatctc gatcatctgt
     1561 taaactgcat aatggacatg gtagagaaga cgaggcgatc cctcactgta ctaagacgat
     1621 gtcaggaagc agaccgggaa gaactgaatt actggatccg gaggtacagt gatgctgagg
     1681 acttgaaaaa gggcggcagc ggtagcagca gccactccag gcaacagagc cccgtcaatc
     1741 cggacccagt cgcattagat gcacatcggg aattccttca caggcctgcg tctggatacg
     1801 tgccagagga gatctggaag aaagctgagg aggctgtgaa tgaggtgaag cgacaggcaa
     1861 tgacggagct gcagaaagcc gtgtctgaag ccgagaggaa agcccatgac atgatcacca
     1921 cagagcgagc caaaatggaa cgcacggtgg ctgaagccaa gcggcaggcc gcagaggatg
     1981 ctctggcagt catcaaccag caggaagact ccagtgagag ttgctggaac tgtggccgga
     2041 aagcaagtga gacctgcagc ggctgtaaca cggcccgata ctgtggctct ttttgccagc
     2101 ataaagactg ggagaagcat caccacatct gtggacagac cctgcaggcc ccacagcagg
     2161 gagaaacgcc tgctgtcagc tcctcagtca cgcccagcag tggggctggg agcccaatgg
     2221 acacaccacc agcagccact ccgaggtcta ccacccccgg aaccccctcc accatagaga
     2281 cgacgcctcg ctagacctaa actcagactg tcagaggaaa gacaccacaa ccaacacgaa
     2341 agcaattcct catcctcaga tgctcaaagt cccttttctg tttgtttgtt tatagatgaa
     2401 ctatctatct tatttcagta cttcggcaag agagaaccta actgtatctt tgaggcgata
     2461 gtaaaacaca gaggccagta acgggtcgta atgacttact gtggaaaaca aagatatctt
     2521 ttctttagag aactgaaaag agaggaaaga atataacgtg aaatgctaga tttgacctcc
     2581 tccctgttat tttcaagtag ctgggatttt aaactagatg acctcattaa ccaatgcttt
     2641 accaaacagc aaaccaagag attgctaatt gctgttgaaa gcaaaaatgc taatattaaa
     2701 agtcacagtg ttctttatat acaataatgg aaagaaaaaa aaaaaagagg caattcctca
     2761 agggcacgag cgttggatac agcagtagac attttaacaa gaagatgaat ggcgtctgtg
     2821 ggttgctaac tgaactttga agaccggctg caaaacgcac agatgtgcag cagattggaa
     2881 ggagacacag atgttcgttt tttttccccc gtttctgaaa aagaaataat aatatccagg
     2941 tcaacagaat gaaaaatgaa agatgatttc cagtggggtg tatgactaca gcagcaagaa
     3001 aaaaaaaatt gccataatac aaaggctcct ttttatatca cacacacaca cacacacaca
     3061 cacacacaca cacacacaca cacacacact cactctctct ctccctctct ctctctctta
     3121 agagactcag cctgcagtta attagcattc tggcagcttc caagtcagcc agctgcccta
     3181 aataaccctt caacgtttct tcacttttgc aaggttccac agagtaagac attgaatcta
     3241 ttccagctta ttcattttat atcgaaaaac caattttttt aaaaaaaaaa atggcggctt
     3301 cagctccagc ccctttccaa aatttttcaa ccccaccctg tttgggtttt taattaaaat
     3361 ctagtagttc tcttggtatt aaaacacttc tgtcctgtga ggttttccca atggtgtttt
     3421 tcttgtaaat gtgttggaca aatgtgaaga tgcgttgtag ttgatccata tgcccacatt
     3481 tagtctcttt attcctagtt ggtgagagaa accagtatct ttctatgctg cttttatatc
     3541 tgtatgtatt agtgatattt ctctagtagt taaaaaaaaa aaatgaaaag aaaagaaaaa
     3601 aaaaaaccac actttttttg gttgtcctca agaaaagaag aaaagaaaag aaaagaaaaa
     3661 gctatctttt ggagctgcta actcactctc ttataggatt tttttcctgg aaaccagcat
     3721 gcttcatgga atgctagcac atggatgttt ttaagaggga tgtacataaa tgtattttgc
     3781 actgtcacaa tgactcccta ggcatgcttt ttttttttca aaccaacttt ttaaatatgc
     3841 tagagccatt tcaccaattt tagctgtagc atagagtagt agtggaattt ttcttttatc
     3901 ctttttttta tgaaaaaaaa aattattagg gactttttaa aaaaaaataa aataagatat
     3961 cctactttaa aaaaaaagga cagtgcatgc atattgctgt aaggttgttt aagtatttct
     4021 aattttacaa aaaaaaaatg aaaaaaaaaa tcattagctc tccaaatgct gaggtgtaga
     4081 cggacagctt tagccctgct gagtgccagg ttatacagta ttcttacaaa agggaagtca
     4141 gccaaagact gatctgatgg accaaaatcg gaatttttga aaagcaccag taatcctttc
     4201 caaatgatca gcaggttaaa catgttcagt gtgactccat taacccttcg ttgtccaggg
     4261 tccagaccag aactacttgt tagttttgaa acacattatt agcccaggat gtggttgtgt
     4321 gctttaagag tcggcagtgc tgcaggctgt gtagacaacc aaagttgaaa ggctgggaag
     4381 acacttttcc acatacacat acaccaggca tttctttaca aaattgagta caatccatta
     4441 gcttgtggga ggggggagcg ggtaatgtag cccttggata cagttttaag tggttgtgtt
     4501 ttaagttttc tgcatagatg caatcctcac gggattgctt catgtctcgc aaatctaagg
     4561 tttccttaaa ccatttcccc tgtattttca tataccagtc ggttttgatt ttgtcccggt
     4621 agtgttgtgt tcttttctct tgtcgtcgtc gtcgttgttt tcaatggcct tttagtttag
     4681 gaagttctga tgagcgaatc aatgcatcta tctatctgca tgttggaagt ccatctgcca
     4741 gcacacccgc taaggcaaag agaagcgcat aaccaggctg cgaatgggtt ctattttacc
     4801 atggtgctcc cagaatcctt tgacctcatt ctgctttcta gtctgcttgt gacactggac
     4861 agtcctttct tagagctatt atatgttcta ggctacgaag ggttaaataa tcccaaaaaa
     4921 aataacaaaa aaaaatgagg tatgtcatac cctcgcgtct cgatctcaag aagctgtgat
     4981 gtatgtggaa cagcactgtt attctgaaca ctagtgtgta aaataaggat tagtacagta
     5041 cgtctcattc cttttttaat tcagggcacc ctgagtgaaa accaatacaa aaaaaaaaaa
     5101 aaatccctaa ctctgagctc tgtctctaat tcctcttcct ccttcccctc ttcctcctcc
     5161 tcttcctcta ctcctgtttt gctacattct cctcagtggc aaaaagtttc actctacctc
     5221 tgacagcatg tatattgcac cagtcgctaa cgaaaactgg tctagtcaaa ccaaatgggc
     5281 acaaaagaac caggatacca aaagttaagc tcatacagct gcgaaccata tcacttcttg
     5341 gtaacaatgc agacctcata aacctaaaaa aaaagagaaa gaaaagaaaa cttttgttac
     5401 tttccttttt tgcttgtcac ttatatacag gctatgtgag agtattcatt tgtaggtatt
     5461 acacattaaa aaaaaaaagc tatcttcatt ggatagaact gaatggtggt cgctgatagg
     5521 aatagggcgt cctctatctc ttatctctgt ctcttttctc tttctctttc tctgtcatga
     5581 gactgtgtgt gacagggcta cctgtctttt taatttgttt tctgaacttt ttttttttaa
     5641 tgtgtaggtg catgtcttgg ggatttaaaa atttcaaggc tggtttactt atgcaaagca
     5701 tgcctatgtc tggaatactt agggaaagaa agtgactcca tgttgtccga attcctcaag
     5761 ggacagaaaa acaaattgga gactgttgaa atgcagattt gaagtaattt tatttttaat
     5821 tattttgggt tctgcgacat tattgtgaaa aattaaagtc gttgtgcaat acttaattca
     5881 gacacgtgcc acaagttaac ggtagactaa cactgggggg cgggggctag gcatcacgct
     5941 tttgtctgca tactcttgag cttttaagtc tactatgtct gaactgtggt ttcttgttta
     6001 tccttttttg ttttttcctt agttggactg taatgtatgg tctgtcaacc tgtgaatctt
     6061 taaagtatga ttcaggtatt gttgtactct ttaccgtgta ataaaaatgc ttaaaaaaaa
     6121 aagtcagtag tccgtctccc ttatctttac tgtgtgcccg ccaaggctac cactcaggaa
     6181 cctcattctt gaagggcagt tcttcatgga gcatgcccag agtctagtca gctacagagt
     6241 atgtctctaa cgtgttaatt cgcccacgag tgatgaggga gaaggagaga acacagagga
     6301 catttctgag gtcatagtag tccaatatag aaggatactc caagtcctcc ataagaaagg
     6361 atagcttatg ctaggggtca ccgtctccag aaaggtccaa ttgccatctt tttaaactct
     6421 ggcttgcagc atgtttcttt cattctcagc tgcaggatgt acccactaag gcagatctct
     6481 tcctccatct gtcctggatc ctcaccgcct ttaattagaa gttgccagca tgttcacact
     6541 tggttttgta catttgtaaa tacacagtat gttgtgtcca tcttgtttct gagacccatg
     6601 ttgtccattt aacacgcacc agtatatttt ttttcatgca ctagctataa aaaataactt
     6661 agactttgga gaacctattg gtcatctacc atagaaactc agtcaatttt cacgtacttt
     6721 acacaacaca ttttttaatg actgtatata ctgcattgta gcagaatttc tgatttgctt
     6781 ggaagattcc cgctatggcc taaaactagc ttaaagggat caagtgaaat gcaagaactg
     6841 aatctggaga gacagagaag tcacatagac gctgtcgagt gggaggataa cctagggcct
     6901 tctcttcagt ttcctttgta cgccagctag gcccctatgc ctgtcctgag gcctggcttc
     6961 tccaaatgat gttgagaaat gcagcctatt ttacagagtg aggaagggag cggggaaggg
     7021 agggagggag gagggagaaa gagagagaga gagagagaga gagagagaga gagtttaaaa
     7081 gcatagctag tgcgtatctt attcctacaa aataaacagg ctgagtattt agttttgtag
     7141 ttaatttttc ccctcactcc aaagcctgac cagcgtggct caacttgctt ttcttatttg
     7201 tacagataca ttttcttttt cttttcaaag tggaacagac cagaaaccag aagacatgga
     7261 ggacataact gagatgcctt gaagtagccc ctttataagc tgtccttgaa aaacagctct
     7321 gtgacctatt tgtatgactg gattgctaga caaatgagta atgagtttag tttagaggaa
     7381 gaatgtgaac aaaatcagct tctgggtggt aagcaccatt ttttaaaaga atgtaattga
     7441 tgtatttgat aatataaaaa tgatgtttgc catgaaagaa cactaagtta tttccccaga
     7501 ttggaagggg aagaaatgat caaagaggtg cttttctgta tgggtattta tatctttatt
     7561 tcaaggtgaa tgaataaagt tgtacttgcc taaa
//
LOCUS       NM_001436938             441 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 6, mRNA.
ACCESSION   NM_001436938
VERSION     NM_001436938.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 441)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 441)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 441)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 441)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 441)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 441)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 441)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.190457.1,
                                           SRR26360194.1854877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840124
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000005.1  61741152-61741221   c
            71-123              JAXUCZ010000005.1  61738859-61738911   c
            124-256             JAXUCZ010000005.1  61737621-61737753   c
            257-441             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..441
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..70
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..413
                     /gene="Ccl27"
                     /note="isoform c is encoded by transcript variant 6; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform c"
                     /protein_id="NP_001423867.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MWRRERRLPLTGWHPWNKTKEKQEALPLPSSTSCCTQLYRQPLP
                     TRLLRRIVRVELQEADGDCHLQAVVLHLTRRSVCVHPQNRSLARWLERHGKRLQGTLP
                     SLNPVLQKKMCPSPQKQK"
     misc_feature    144..326
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    144..326
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            71..123
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            124..256
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            257..441
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctttgcag gatctactgg ggctgcttct acttttttcc ttggctgcga atgtggcgca
       61 gggagcggag gctcccgctg acaggctggc atccgtggaa caagactaag gagaagcaag
      121 aagccttgcc actgccctcc agcactagct gctgtactca gctctatagg caaccactcc
      181 caaccagact actgaggagg atcgtccgtg tggagctgca ggaggctgac ggggactgcc
      241 acctccaagc tgttgtgctt cacctgactc ggcgcagtgt ctgtgttcat ccccagaacc
      301 gtagcctggc tcggtggtta gaacgccatg ggaaaaggct ccaggggacc ctacccagtt
      361 taaatccggt actacaaaag aaaatgtgcc cgagccccca aaagcaaaag taataaagca
      421 acattagacg ataatctcca a
//
LOCUS       NM_001436937             570 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 5, mRNA.
ACCESSION   NM_001436937
VERSION     NM_001436937.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 570)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 570)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 570)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 570)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 570)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 570)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 570)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 570)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 570)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB715300.1, SRR26360186.437627.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000005.1  61741780-61741850   c
            72-139              JAXUCZ010000005.1  61741422-61741489   c
            140-199             JAXUCZ010000005.1  61741152-61741211   c
            200-252             JAXUCZ010000005.1  61738859-61738911   c
            253-385             JAXUCZ010000005.1  61737621-61737753   c
            386-570             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..570
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..71
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     exon            72..139
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..542
                     /gene="Ccl27"
                     /note="isoform b is encoded by transcript variant 5; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform b"
                     /protein_id="NP_001423866.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERRLPLTGWHP
                     WNKTKEKQEALPLPSSTSCCTQLYRQPLPTRLLRRIVRVELQEADGDCHLQAVVLHLT
                     RRSVCVHPQNRSLARWLERHGKRLQGTLPSLNPVLQKKMCPSPQKQK"
     misc_feature    273..455
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    273..455
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            140..199
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            200..252
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            253..385
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            386..570
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccgtttc cggggcggag ccagggaggg cggggagttt aggctgtacc gacccctgag
       61 ccccccttca ggaaccgttc ggagctcgag acatgtcgcg attgaggaga tacgaggtgg
      121 cgctggaagc ggaggaggag atctactggg gctgcttcta cttttttcct tggctgcgaa
      181 tgtggcgcag ggagcggagg ctcccgctga caggctggca tccgtggaac aagactaagg
      241 agaagcaaga agccttgcca ctgccctcca gcactagctg ctgtactcag ctctataggc
      301 aaccactccc aaccagacta ctgaggagga tcgtccgtgt ggagctgcag gaggctgacg
      361 gggactgcca cctccaagct gttgtgcttc acctgactcg gcgcagtgtc tgtgttcatc
      421 cccagaaccg tagcctggct cggtggttag aacgccatgg gaaaaggctc caggggaccc
      481 tacccagttt aaatccggta ctacaaaaga aaatgtgccc gagcccccaa aagcaaaagt
      541 aataaagcaa cattagacga taatctccaa
//
LOCUS       NM_001436904            7025 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, F
            (Ptprf), transcript variant 4, mRNA.
ACCESSION   NM_001436904 XM_063287877
VERSION     NM_001436904.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7025)
  AUTHORS   Dyck,S., Kataria,H., Akbari-Kelachayeh,K., Silver,J. and
            Karimi-Abdolrezaee,S.
  TITLE     LAR and PTPsigma receptors are negative regulators of
            oligodendrogenesis and oligodendrocyte integrity in spinal cord
            injury
  JOURNAL   Glia 67 (1), 125-145 (2019)
   PUBMED   30394599
  REMARK    GeneRIF: In a spinal cord injury model, blocking LAR and PTPalpha
            receptors promotes oligodendrogenesis.
REFERENCE   2  (bases 1 to 7025)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: This study showed that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 7025)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7025)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   5  (bases 1 to 7025)
  AUTHORS   Song,Y.S., Lee,H.J., Prosselkov,P., Itohara,S. and Kim,E.
  TITLE     Trans-induced cis interaction in the tripartite NGL-1, netrin-G1
            and LAR adhesion complex promotes development of excitatory
            synapses
  JOURNAL   J Cell Sci 126 (Pt 21), 4926-4938 (2013)
   PUBMED   23986473
REFERENCE   6  (bases 1 to 7025)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Increased abundance of specific skeletal muscle protein-tyrosine
            phosphatases in a genetic model of insulin-resistant obesity and
            diabetes mellitus
  JOURNAL   Metabolism 44 (9), 1175-1184 (1995)
   PUBMED   7666792
REFERENCE   7  (bases 1 to 7025)
  AUTHORS   Ahmad,F., Considine,R.V. and Goldstein,B.J.
  TITLE     Increased abundance of the receptor-type protein-tyrosine
            phosphatase LAR accounts for the elevated insulin receptor
            dephosphorylating activity in adipose tissue of obese human
            subjects
  JOURNAL   J Clin Invest 95 (6), 2806-2812 (1995)
   PUBMED   7769120
REFERENCE   8  (bases 1 to 7025)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 7025)
  AUTHORS   Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E.
  TITLE     Cloning, bacterial expression, purification, and characterization
            of the cytoplasmic domain of rat LAR, a receptor-like protein
            tyrosine phosphatase
  JOURNAL   J Biol Chem 266 (29), 19688-19696 (1991)
   PUBMED   1918076
REFERENCE   10 (bases 1 to 7025)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  137109266-137109453 c
            189-268             JAXUCZ010000005.1  137102816-137102895 c
            269-403             JAXUCZ010000005.1  137095316-137095450 c
            404-549             JAXUCZ010000005.1  137087255-137087400 c
            550-691             JAXUCZ010000005.1  137086942-137087083 c
            692-880             JAXUCZ010000005.1  137074901-137075089 c
            881-991             JAXUCZ010000005.1  137066584-137066694 c
            992-1261            JAXUCZ010000005.1  137056469-137056738 c
            1262-1843           JAXUCZ010000005.1  137054602-137055183 c
            1844-1980           JAXUCZ010000005.1  137054243-137054379 c
            1981-2125           JAXUCZ010000005.1  137053623-137053767 c
            2126-2431           JAXUCZ010000005.1  137049945-137050250 c
            2432-2625           JAXUCZ010000005.1  137049152-137049345 c
            2626-2743           JAXUCZ010000005.1  137045007-137045124 c
            2744-2841           JAXUCZ010000005.1  137043586-137043683 c
            2842-3095           JAXUCZ010000005.1  137043147-137043400 c
            3096-3189           JAXUCZ010000005.1  137042968-137043061 c
            3190-3408           JAXUCZ010000005.1  137042165-137042383 c
            3409-3563           JAXUCZ010000005.1  137041639-137041793 c
            3564-3679           JAXUCZ010000005.1  137039093-137039208 c
            3680-3777           JAXUCZ010000005.1  137035917-137036014 c
            3778-3901           JAXUCZ010000005.1  137032859-137032982 c
            3902-4077           JAXUCZ010000005.1  137032561-137032736 c
            4078-4197           JAXUCZ010000005.1  137031787-137031906 c
            4198-4352           JAXUCZ010000005.1  137031401-137031555 c
            4353-4638           JAXUCZ010000005.1  137031039-137031324 c
            4639-4817           JAXUCZ010000005.1  137030760-137030938 c
            4818-4944           JAXUCZ010000005.1  137030412-137030538 c
            4945-5070           JAXUCZ010000005.1  137030057-137030182 c
            5071-5225           JAXUCZ010000005.1  137029744-137029898 c
            5226-5361           JAXUCZ010000005.1  137029514-137029649 c
            5362-7025           JAXUCZ010000005.1  137027376-137029039 c
FEATURES             Location/Qualifiers
     source          1..7025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7025
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="protein tyrosine phosphatase, receptor type, F"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
     exon            1..188
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="upstream in-frame stop codon"
     exon            189..268
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..403
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..5430
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /EC_number="3.1.3.48"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; receptor-type tyrosine-protein phosphatase F;
                     leukocyte antigen-related (LAR) PTP receptor; leukocyte
                     common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     isoform 4 precursor"
                     /protein_id="NP_001423833.1"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
                     /translation="MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSS
                     YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVR
                     VSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQ
                     IRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGA
                     RSKPKVVTTTGAVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGH
                     SMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRF
                     SLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPEELELDELLEAIEQGEEKQR
                     RRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPM
                     DQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTH
                     SPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKAND
                     GLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYI
                     NANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW
                     PARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEY
                     PTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHV
                     TCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTA
                     MELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYIN
                     ASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP
                     AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTG
                     EGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT
                     VKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT"
     sig_peptide     313..399
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    2440..2733
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    2440..2733
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(2698..2703,2707..2712)
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2698..2703,2707..2712)
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2752..>2931
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    2752..>2931
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    3709..4536
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    3709..4536
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    4540..5412
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     misc_feature    4540..5412
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     exon            404..549
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            550..691
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            692..880
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            881..991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1261
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1843
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1980
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2431
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2625
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2743
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2841
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3095
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3189
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3408
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3563
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3679
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3777
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3901
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4077
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4197
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4352
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4638
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4639..4817
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4944
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4945..5070
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5071..5225
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5226..5361
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5362..7025
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcggtg gcggcggcgg cagaggcggc ggctccggct ccagctccgg ctccggctcc
       61 tgttagggcg gcggtggagg tggcggtggc ggtggcggga gcgggcgacg gcggcagcgg
      121 cggactgaga acggcggcct cagcggcgcg aggcggggac atgcagaccg acggcccccg
      181 gagaggcgga aggagcggag gccctggtgc cctgccctca gtgctgactg cccagcgaga
      241 gtgactggta taaacaagaa gagaccgggt gattgtcttg ggctgtggct ggctgtggag
      301 ctagaaccct ggatggcccc cgagccagcg ccagggagga ggatggtgcc ccttgtgcct
      361 gccctcgtga tgctgggttt gatggcaggt gctcatggcg acagcaaacc tgtctttgtt
      421 aaggtccccg aggaccagat cgggctgtcg ggaggggtgg cctccttcgt gtgccaagcc
      481 acaggggaac ccaagcctcg aatcacatgg atgaagaagg gaaagaaagt cagctcccag
      541 cgctttgagg taattgagtt tgacgacgga gcagggtcag tgctgcggat ccagccatta
      601 cgagtgcagc gagacgaagc catctatgag tgcacggcca cgaacagtct cggcgagatc
      661 aacacaagtg ccaagctgtc agtacttgaa gaggaccagc tgccgtctgg gttcccgact
      721 atcgacatgg gacctcaact gaaggtggtg gagaaggctc gcactgccac catgctgtgt
      781 gcagctggtg gaaatccaga ccctgagatc tcttggttca aagacttcct tcctgtggac
      841 cctgcttcaa gcaacggtcg tatcaagcag ctgcgttcag gtgcattgca gattgagagc
      901 agcgaggagt ctgaccaagg caagtacgag tgtgtggcaa ccaactcggc aggcacacgc
      961 tactcggccc ccgccaacct gtatgtgcga gtgcgccgcg tggctcctcg tttctccatc
     1021 cctcccagca gccaagaggt aatgccgggc ggcaacgtga acctcacgtg tgtggcagtg
     1081 ggagcaccca tgccgtatgt gaagtggatg atgggcgccg aggaacttac caaagaggac
     1141 gagatgccag ttggccgcaa tgtgctggag ctcagcaatg tcatgcggtc tgccaactat
     1201 acctgtgtgg ccatctcttc actgggcatg atagaggcca cagcccaggt cacagtaaaa
     1261 gctctgccaa agcctccaat tgatcttgtg gtgacagaga caactgccac cagtgttacc
     1321 ctgacatggg actctggaaa taccgagcct gtgtctttct acggcatcca gtaccgtgca
     1381 gctggcacag atggcccctt ccaggaagtg gatggtgtgg ccagcacccg atacagcatt
     1441 ggtggcctca gccctttttc agaatatgcc ttccgtgtgt tggctgttaa cagcattggg
     1501 cgaggaccac ccagtgaggc agtgcgagcg cgcacgggtg agcaggcacc ctccagccct
     1561 ccacgccgtg tgcaggcccg aatgctgagc gccagcacca tgctggtaca gtgggaaccc
     1621 cctgaagagc ccaatggcct ggtacgggga tatcgagtct actacacccc agactctcga
     1681 cgccccttga gcgcctggca caagcataac accgacgcag gactccttac caccgtgggc
     1741 agcctgctac ctggcatcac ctacagcctc cgcgtcctgg cctttactgc cgtgggcgac
     1801 ggccctccca gccccaccat ccaagtcaag acacagcagg gagtgcctgc acagcctgca
     1861 gacttccagg ccaaagccga gtcggacacc aggatccagc tatcatggct gctgcccccg
     1921 caggagcgga tcatcaagta tgagctggtg tactgggcag cagaggatga aggccagcag
     1981 cacaaggtga ccttcgaccc cacctcctcc tacactctgg aggacctgaa gcctgacaca
     2041 ctgtaccact tccagctggc tgctcgctca gatttggggg tgggcgtctt cactcccacc
     2101 gtagaggccc gtacagcaca gtccacccca tccgcccctc cccagaaggt gacatgtgtg
     2161 agcacgggct ccaccacggt ccgggtaagt tgggttccac cgccggctga cagccgcaac
     2221 ggcattatca cccagtactc cgtggcctat gaggcagtgg acggcgagga ccgtaaacgg
     2281 catgtggtgg atggcatcag ccgtgagcat tccagctggg acctgttggg cctggagaag
     2341 tggacggagt accgggtgtg ggtgcgggca cacacagatg tgggccctgg ccctgagagc
     2401 agcccggtgc tggtgcgcac cgacgaggac gtgcctagcg ggccaccacg gaaggtggag
     2461 gttgagcctc tgaactccac tgctgtgcat gtctcctgga agctgcccgt ccccaacaag
     2521 cagcacggac agattcgtgg ctaccaggtc acctatgtgc ggctggagaa tggggagccc
     2581 cgaggccagc ccatcatcca ggatgtcatg ctggctgagg ctcaggaaac caccatcagc
     2641 ggcctcaccc ccgagaccac ctactccatt actgttgctg cctacaccac taagggggac
     2701 ggtgcccgaa gcaagcccaa agtggttact accacagggg cagtgtttgc caagaatttc
     2761 cgtgtggccg ctgcaatgaa gacatctgtg ctgctcagtt gggaggtccc cgactcttac
     2821 aagtcagctg tacccttcaa gatcctgtac aatgggcaga gcgtggaggt ggatgggcac
     2881 tccatgcgga agctgattgc agacctgcaa cccaacacgg agtactcctt cgtcctgatg
     2941 aaccgcggca gcagcgctgg gggcctacag cacctggtgt ccatccgcac tgccccagac
     3001 ctcctgcctc agaagccact gcctgcctct gcctttatag aggatggccg cttctccctc
     3061 tccatgcctc aagtgcagga cccctcgcta gtcaggtggt tctacattgt ggtggtgccc
     3121 attgaccgtg tgggcgggaa cctgctggca ccaagatgga gcacaccaga ggagctggag
     3181 ctggacgagc ttctggaggc catcgagcag ggtgaggaga aacagcggag gcgtcggcgc
     3241 caagcagagc ggctgaagcc ttacgtggca gctcaagtgg acgagctccc tgagaccttc
     3301 accctggggg acaagaagaa ctaccgtggc ttctacaacc ggcccctgtc tccggatctg
     3361 agttaccagt gctttgtgct cgcctccctc aaggaaccca tggaccagaa gcgctatgcc
     3421 tccagcccct actcggacga gatcgtagtc caggtgacac cagcccagca gcaggaggag
     3481 cccgagatgc tgtgggtgac aggccctgtc ctggcagtca ttctcatcat actcattgtc
     3541 atcgctatcc tcctattcaa gaggaagaga acacattccc catcgtcaaa ggatgagcag
     3601 tcaatcgggc tgaaggactc cctgttggcc cactcttctg accctgtgga aatgcgaagg
     3661 cttaactacc agaccccagg tatgcgagac cacccgccca tccccatcac tgacctggca
     3721 gacaatattg aacgtctcaa agccaatgat gggctcaagt tctcccagga gtatgagtcc
     3781 attgaccctg gacagcagtt cacgtgggag aattccaact cagaggtgaa caagcccaag
     3841 aaccgctatg caaacgtcat tgcctatgac cactctcgag tcctcctcac ctccattgat
     3901 ggtgttcctg ggagtgacta catcaatgcc aactacattg atggctaccg aaagcagaat
     3961 gcctacatcg ccacacaggg tccgctgcct gagaccatgg gtgatttctg gaggatggtg
     4021 tgggaacagc gtacagccac agtggtcatg atgaccaggc tagaggagaa atcccgggtg
     4081 aagtgtgatc agtattggcc agcccgtggc actgagacct atggcctcat tcaggtgacc
     4141 ctggtggaca ctgtggagtt ggccacgtac accatgcgca ccttcgcact ccataagagc
     4201 ggctccagtg agaagcgtga gctgcgtcag ttccagttca tggcctggcc agaccatggg
     4261 gttcctgagt accccactcc catcttggcc ttcctgagac gggtcaaggc ctgtaacccg
     4321 ctagatgcag gacccatggt ggtgcattgc agtgctggtg tgggccgcac gggctgcttc
     4381 attgtcatcg acgcaatgct ggagcgtatg aagcacgaga agacagttga catctatggc
     4441 cacgtgacgt gcatgcgctc gcaaaggaac tacatggtgc agacagagga ccagtatgtg
     4501 ttcatccacg aggcactgtt agaggctgcc atgtgcggac acactgaggt gcttgctcga
     4561 aacctctatg cccacatcca gaagctaggc caagtgcctc ccggggagag tgtcactgcc
     4621 atggagcttg agttcaagtt gctggccaac tccaaggccc acacgtctcg cttcattagt
     4681 gccaacctgc cctgcaacaa gttcaagaac cgcctggtga acatcatgcc ctatgagctg
     4741 actcgagtgt gcctgcaacc catccgtggt gtggagggct ctgactacat caatgccagc
     4801 tttctagatg gctacagaca gcagaaggcc tacatagcta cacaggggcc tctggccgag
     4861 agcaccgagg acttctggcg catgttatgg gagcacaatt ccaccatcat cgtcatgctg
     4921 acgaagcttc gggagatggg cagggagaaa tgtcaccagt actggccagc agagcgctct
     4981 gctcgctatc aatactttgt cgttgacccg atggctgagt acaacatgcc ccagtatatc
     5041 ctgcgtgaat tcaaagtcac agatgcccgg gatgggcagt caaggacaat ccgacagttc
     5101 cagtttacag actggccaga gcaaggagta cccaagacgg gggaaggctt catcgacttc
     5161 atcgggcagg tgcacaagac aaaggagcag tttggacagg atgggcccat cacagtacac
     5221 tgcagtgctg gtgtgggccg cacaggggtg tttatcaccc tgagcattgt cctggagcgc
     5281 atgcggtacg agggcgtggt tgacatgttc cagaccgtga agaccctccg cacacagcgc
     5341 cctgcaatgg tgcagacaga ggaccaatac cagctgtgct accgtgcggc cctggaatac
     5401 ctcggcagct ttgatcacta tgcaacgtaa ctactgctcc cctctcctcc gccgctcccc
     5461 tgaggggctc cggaggggac ccagctcctc tgagccatac cgaccatcgt ccagccctcc
     5521 tgcacggatg ctgttgccgg cagagcacag cccactggga tcacagcatt tcgggaacat
     5581 tgccacacca gtcagagagc ccagaacacc tgggcaagta ggcggactgg cagcctggct
     5641 ctgggccctc gtccaccggg cccaagtgga gccctgcttc aagctctctg ttcagctccg
     5701 cgattctcat gcttctcatg gggtgggaaa gggggcagag ccccccacgt tttatacatt
     5761 taggcggggt agactgcggg gtcctagcct cttcctccga ctttcctttt gcaggtcttt
     5821 cactacagat tgggctgctg tgggagttgg gacttacttg ttttcctttt tgagttcacg
     5881 ttggatcctt gtacaacttc tgcggaagga cacagtacac gctttccttc ctcgagcaga
     5941 gctagggccc tacctgagca agtcggctgt ggcccgggag gcagctgaga ctcctgctgt
     6001 cctccagcct ttcagaggag atcctattcc agccaaatgc agggaaacac tttattttgt
     6061 tttaggtttt gtttttcctt gagagccttt ttttaggccc cacagacagt ggtgggcggg
     6121 gaggcgatag gaaacacatc cccagtgtgc atttaacatt catagcctac aaccacagac
     6181 gtgtctgggg ggagcctggc aaggcgttcc tcgtcaccat cgtgtttgca aaggttcaaa
     6241 aaagcaaaaa ttaaaaaaaa aaaacataaa aatatttttt tttaaaaaaa agaaataaag
     6301 attcatcccc tggcctctcc ttctgctccg aagtgggagg caactcaatg tgcctggggc
     6361 tcgttgtggg cccacagagt cttgctgtca tccccagcgg tgcagtgtgg caggtgtttg
     6421 taagctgtgg gttctggcca cctcggtaac tgaatggcac aggtgagggc ctgtgccacg
     6481 ccccacacac ctcagggcca agcgggggcg tggccggccc ttcaggtcta ggccagtggg
     6541 cctggtagca catgtctgtc ctcagcggga cagatgcttt ctctcctggt ttgcagctgt
     6601 cttcaaatcc cccatgactc gcccttccca ctccttcaag tcgccctcac aaaccaatgt
     6661 ggcaagacta ctggacttgt atccatggta ctctactcag tcctcttatc tcagcttgct
     6721 gaggggcagg gagagggtct cttcctctgg gcagcactat ctaggtagta agtgggggcg
     6781 ggaaagggtg catagctgtt ttagccgaag gactcgatgt ggacgtcctc agatatagct
     6841 aggctaagcg gagatcgacg gtccggggtt ggtggtgttg gatgagacat tcatttttac
     6901 cttgtggacg ctagtgctgt agagttcact gttgtacaca gtctgttttc tatttgttaa
     6961 ggaaaactac agcatcattg catacttctt gatggtaata aatttgaata atcagatttc
     7021 ttaca
//
LOCUS       NM_001436918            7397 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 6, mRNA.
ACCESSION   NM_001436918 XM_006237904
VERSION     NM_001436918.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7397)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7397)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7397)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7397)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7397)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7397)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006237904.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14727.1,
                                           SRR26643299.22048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               JAXUCZ010000005.1  31984712-31985081
            371-508             JAXUCZ010000005.1  32078977-32079114
            509-750             JAXUCZ010000005.1  32081132-32081373
            751-840             JAXUCZ010000005.1  32085402-32085491
            841-1022            JAXUCZ010000005.1  32089757-32089938
            1023-1273           JAXUCZ010000005.1  32102023-32102273
            1274-1359           JAXUCZ010000005.1  32107640-32107725
            1360-1561           JAXUCZ010000005.1  32108284-32108485
            1562-1630           JAXUCZ010000005.1  32117199-32117267
            1631-1821           JAXUCZ010000005.1  32122846-32123036
            1822-7397           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7397
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..370
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="upstream in-frame stop codon"
     CDS             343..2097
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform d is encoded by transcript variant 6;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform d"
                     /protein_id="NP_001423847.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MVGLFSLVQYRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQG
                     APRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQ
                     LSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPF
                     VIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNE
                     NGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPP
                     PQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEW
                     KHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSGSSSH
                     SRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSE
                     AERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSG
                     CNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAA
                     TPRSTTPGTPSTIETTPR"
     misc_feature    646..915
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    646..915
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1291..1491
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1291..1491
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1609..>1773
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1609..>1773
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1825..1935
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1825..1935
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            371..508
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..750
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..840
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1022
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1273
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1359
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1561
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1630
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1821
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..7397
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcacatt tgtctgccac agcagcaaca acagagagga gcggagggag ggagcgaggc
       61 gggaggaggg ggagctgagc tcggcgcgcg ccgggctccg cgtcgcagcc tgcgtctgcc
      121 tggcgtccgc caccccgggc tcctcgccct gcatctcgct gtgcgaagcg gctgtccgca
      181 atcctcaaga ctaggcggtc ggtctctggg cgagcgcgag tgggcgagtg gccacggaca
      241 ttctggcatc gcgagggagg cggcgccgcg ccctggtcct ctggccccgc cggccagcac
      301 cgaccgcagg aagttttatt tgcagctggg agcccgcggc ggatggtggg actcttcagc
      361 cttgtgcagt atcgtaccga gaagcactcc acgatgccag actcacctgt ggatgtgaag
      421 acgcagtcta ggctgactcc cccagcaatg ccgcctcctc cgaccactca aggagccccg
      481 agaaccagtt cgtttacgcc aacgacatta acgaatggca ccagccattc acccacggcc
      541 ttgaatggcg ccccctcacc gcctaatggc tttagcaacg ggccttcctc ttcctcttcc
      601 tcttctctgg ctaatcaaca gctgccccca gcctgtggtg ctagacaact gagcaagctg
      661 aagcgatttc ttactaccct gcagcagttt ggcaatgaca tttcaccaga gattggagaa
      721 agagttcgca ctcttgtact aggactggtg aactctactt tgacaattga agaatttcat
      781 tccaaacttc aagaagctac taacttccca ctgagacctt ttgtcatccc gtttttgaag
      841 gccaacctgc ccctgctaca gcgtgaactc ctccactgcg caaggctagc caaacagaac
      901 cctgcccagt acctcgctca gcacgaacag ctgcttctgg atgccagcac cacctcccct
      961 gtcgactcct cagagctgct tctcgatgtg aacgaaaacg ggaagaggcg aactccagac
     1021 agaaccaaag aaaatggctt tgacagagag cctttgcact cagaacatcc aagcaagcga
     1081 ccatgcacta ttagcccagg ccagcggtac agtccaaata atggcttatc ctaccagcca
     1141 aatggcctgc ctcaccccac cccacctcca cctcagcatt accgtttgga tgatatggcc
     1201 attgcccacc actacaggga ctcctatcga caccccagcc acagggacct cagggacaga
     1261 aatagaccta tggggttaca tggcacacgt caagaagaaa tgattgacca cagactaaca
     1321 gacagagaat gggcagaaga gtggaagcat ctcgatcatc tgttaaactg cataatggac
     1381 atggtagaga agacgaggcg atccctcact gtactaagac gatgtcagga agcagaccgg
     1441 gaagaactga attactggat ccggaggtac agtgatgctg aggacttgaa aaagggcggc
     1501 agcggtagca gcagccactc caggcaacag agccccgtca atccggaccc agtcgcatta
     1561 gatgcacatc gggaattcct tcacaggcct gcgtctggat acgtgccaga ggagatctgg
     1621 aagaaagctg aggaggctgt gaatgaggtg aagcgacagg caatgacgga gctgcagaaa
     1681 gccgtgtctg aagccgagag gaaagcccat gacatgatca ccacagagcg agccaaaatg
     1741 gaacgcacgg tggctgaagc caagcggcag gccgcagagg atgctctggc agtcatcaac
     1801 cagcaggaag actccagtga gagttgctgg aactgtggcc ggaaagcaag tgagacctgc
     1861 agcggctgta acacggcccg atactgtggc tctttttgcc agcataaaga ctgggagaag
     1921 catcaccaca tctgtggaca gaccctgcag gccccacagc agggagaaac gcctgctgtc
     1981 agctcctcag tcacgcccag cagtggggct gggagcccaa tggacacacc accagcagcc
     2041 actccgaggt ctaccacccc cggaaccccc tccaccatag agacgacgcc tcgctagacc
     2101 taaactcaga ctgtcagagg aaagacacca caaccaacac gaaagcaatt cctcatcctc
     2161 agatgctcaa agtccctttt ctgtttgttt gtttatagat gaactatcta tcttatttca
     2221 gtacttcggc aagagagaac ctaactgtat ctttgaggcg atagtaaaac acagaggcca
     2281 gtaacgggtc gtaatgactt actgtggaaa acaaagatat cttttcttta gagaactgaa
     2341 aagagaggaa agaatataac gtgaaatgct agatttgacc tcctccctgt tattttcaag
     2401 tagctgggat tttaaactag atgacctcat taaccaatgc tttaccaaac agcaaaccaa
     2461 gagattgcta attgctgttg aaagcaaaaa tgctaatatt aaaagtcaca gtgttcttta
     2521 tatacaataa tggaaagaaa aaaaaaaaag aggcaattcc tcaagggcac gagcgttgga
     2581 tacagcagta gacattttaa caagaagatg aatggcgtct gtgggttgct aactgaactt
     2641 tgaagaccgg ctgcaaaacg cacagatgtg cagcagattg gaaggagaca cagatgttcg
     2701 ttttttttcc cccgtttctg aaaaagaaat aataatatcc aggtcaacag aatgaaaaat
     2761 gaaagatgat ttccagtggg gtgtatgact acagcagcaa gaaaaaaaaa attgccataa
     2821 tacaaaggct cctttttata tcacacacac acacacacac acacacacac acacacacac
     2881 acacacacac actcactctc tctctccctc tctctctctc ttaagagact cagcctgcag
     2941 ttaattagca ttctggcagc ttccaagtca gccagctgcc ctaaataacc cttcaacgtt
     3001 tcttcacttt tgcaaggttc cacagagtaa gacattgaat ctattccagc ttattcattt
     3061 tatatcgaaa aaccaatttt tttaaaaaaa aaaatggcgg cttcagctcc agcccctttc
     3121 caaaattttt caaccccacc ctgtttgggt ttttaattaa aatctagtag ttctcttggt
     3181 attaaaacac ttctgtcctg tgaggttttc ccaatggtgt ttttcttgta aatgtgttgg
     3241 acaaatgtga agatgcgttg tagttgatcc atatgcccac atttagtctc tttattccta
     3301 gttggtgaga gaaaccagta tctttctatg ctgcttttat atctgtatgt attagtgata
     3361 tttctctagt agttaaaaaa aaaaaatgaa aagaaaagaa aaaaaaaaac cacacttttt
     3421 ttggttgtcc tcaagaaaag aagaaaagaa aagaaaagaa aaagctatct tttggagctg
     3481 ctaactcact ctcttatagg atttttttcc tggaaaccag catgcttcat ggaatgctag
     3541 cacatggatg tttttaagag ggatgtacat aaatgtattt tgcactgtca caatgactcc
     3601 ctaggcatgc tttttttttt tcaaaccaac tttttaaata tgctagagcc atttcaccaa
     3661 ttttagctgt agcatagagt agtagtggaa tttttctttt atcctttttt ttatgaaaaa
     3721 aaaaattatt agggactttt taaaaaaaaa taaaataaga tatcctactt taaaaaaaaa
     3781 ggacagtgca tgcatattgc tgtaaggttg tttaagtatt tctaatttta caaaaaaaaa
     3841 atgaaaaaaa aaatcattag ctctccaaat gctgaggtgt agacggacag ctttagccct
     3901 gctgagtgcc aggttataca gtattcttac aaaagggaag tcagccaaag actgatctga
     3961 tggaccaaaa tcggaatttt tgaaaagcac cagtaatcct ttccaaatga tcagcaggtt
     4021 aaacatgttc agtgtgactc cattaaccct tcgttgtcca gggtccagac cagaactact
     4081 tgttagtttt gaaacacatt attagcccag gatgtggttg tgtgctttaa gagtcggcag
     4141 tgctgcaggc tgtgtagaca accaaagttg aaaggctggg aagacacttt tccacataca
     4201 catacaccag gcatttcttt acaaaattga gtacaatcca ttagcttgtg ggagggggga
     4261 gcgggtaatg tagcccttgg atacagtttt aagtggttgt gttttaagtt ttctgcatag
     4321 atgcaatcct cacgggattg cttcatgtct cgcaaatcta aggtttcctt aaaccatttc
     4381 ccctgtattt tcatatacca gtcggttttg attttgtccc ggtagtgttg tgttcttttc
     4441 tcttgtcgtc gtcgtcgttg ttttcaatgg ccttttagtt taggaagttc tgatgagcga
     4501 atcaatgcat ctatctatct gcatgttgga agtccatctg ccagcacacc cgctaaggca
     4561 aagagaagcg cataaccagg ctgcgaatgg gttctatttt accatggtgc tcccagaatc
     4621 ctttgacctc attctgcttt ctagtctgct tgtgacactg gacagtcctt tcttagagct
     4681 attatatgtt ctaggctacg aagggttaaa taatcccaaa aaaaataaca aaaaaaaatg
     4741 aggtatgtca taccctcgcg tctcgatctc aagaagctgt gatgtatgtg gaacagcact
     4801 gttattctga acactagtgt gtaaaataag gattagtaca gtacgtctca ttcctttttt
     4861 aattcagggc accctgagtg aaaaccaata caaaaaaaaa aaaaaatccc taactctgag
     4921 ctctgtctct aattcctctt cctccttccc ctcttcctcc tcctcttcct ctactcctgt
     4981 tttgctacat tctcctcagt ggcaaaaagt ttcactctac ctctgacagc atgtatattg
     5041 caccagtcgc taacgaaaac tggtctagtc aaaccaaatg ggcacaaaag aaccaggata
     5101 ccaaaagtta agctcataca gctgcgaacc atatcacttc ttggtaacaa tgcagacctc
     5161 ataaacctaa aaaaaaagag aaagaaaaga aaacttttgt tactttcctt ttttgcttgt
     5221 cacttatata caggctatgt gagagtattc atttgtaggt attacacatt aaaaaaaaaa
     5281 agctatcttc attggataga actgaatggt ggtcgctgat aggaataggg cgtcctctat
     5341 ctcttatctc tgtctctttt ctctttctct ttctctgtca tgagactgtg tgtgacaggg
     5401 ctacctgtct ttttaatttg ttttctgaac tttttttttt taatgtgtag gtgcatgtct
     5461 tggggattta aaaatttcaa ggctggttta cttatgcaaa gcatgcctat gtctggaata
     5521 cttagggaaa gaaagtgact ccatgttgtc cgaattcctc aagggacaga aaaacaaatt
     5581 ggagactgtt gaaatgcaga tttgaagtaa ttttattttt aattattttg ggttctgcga
     5641 cattattgtg aaaaattaaa gtcgttgtgc aatacttaat tcagacacgt gccacaagtt
     5701 aacggtagac taacactggg gggcgggggc taggcatcac gcttttgtct gcatactctt
     5761 gagcttttaa gtctactatg tctgaactgt ggtttcttgt ttatcctttt ttgttttttc
     5821 cttagttgga ctgtaatgta tggtctgtca acctgtgaat ctttaaagta tgattcaggt
     5881 attgttgtac tctttaccgt gtaataaaaa tgcttaaaaa aaaaagtcag tagtccgtct
     5941 cccttatctt tactgtgtgc ccgccaaggc taccactcag gaacctcatt cttgaagggc
     6001 agttcttcat ggagcatgcc cagagtctag tcagctacag agtatgtctc taacgtgtta
     6061 attcgcccac gagtgatgag ggagaaggag agaacacaga ggacatttct gaggtcatag
     6121 tagtccaata tagaaggata ctccaagtcc tccataagaa aggatagctt atgctagggg
     6181 tcaccgtctc cagaaaggtc caattgccat ctttttaaac tctggcttgc agcatgtttc
     6241 tttcattctc agctgcagga tgtacccact aaggcagatc tcttcctcca tctgtcctgg
     6301 atcctcaccg cctttaatta gaagttgcca gcatgttcac acttggtttt gtacatttgt
     6361 aaatacacag tatgttgtgt ccatcttgtt tctgagaccc atgttgtcca tttaacacgc
     6421 accagtatat tttttttcat gcactagcta taaaaaataa cttagacttt ggagaaccta
     6481 ttggtcatct accatagaaa ctcagtcaat tttcacgtac tttacacaac acatttttta
     6541 atgactgtat atactgcatt gtagcagaat ttctgatttg cttggaagat tcccgctatg
     6601 gcctaaaact agcttaaagg gatcaagtga aatgcaagaa ctgaatctgg agagacagag
     6661 aagtcacata gacgctgtcg agtgggagga taacctaggg ccttctcttc agtttccttt
     6721 gtacgccagc taggccccta tgcctgtcct gaggcctggc ttctccaaat gatgttgaga
     6781 aatgcagcct attttacaga gtgaggaagg gagcggggaa gggagggagg gaggagggag
     6841 aaagagagag agagagagag agagagagag agagagttta aaagcatagc tagtgcgtat
     6901 cttattccta caaaataaac aggctgagta tttagttttg tagttaattt ttcccctcac
     6961 tccaaagcct gaccagcgtg gctcaacttg cttttcttat ttgtacagat acattttctt
     7021 tttcttttca aagtggaaca gaccagaaac cagaagacat ggaggacata actgagatgc
     7081 cttgaagtag cccctttata agctgtcctt gaaaaacagc tctgtgacct atttgtatga
     7141 ctggattgct agacaaatga gtaatgagtt tagtttagag gaagaatgtg aacaaaatca
     7201 gcttctgggt ggtaagcacc attttttaaa agaatgtaat tgatgtattt gataatataa
     7261 aaatgatgtt tgccatgaaa gaacactaag ttatttcccc agattggaag gggaagaaat
     7321 gatcaaagag gtgcttttct gtatgggtat ttatatcttt atttcaaggt gaatgaataa
     7381 agttgtactt gcctaaa
//
LOCUS       NM_001436852            3179 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 2, mRNA.
ACCESSION   NM_001436852 XM_039110062
VERSION     NM_001436852.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110062.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16713.1,
                                           SRR26643429.21496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000005.1  155719734-155719766
            34-227              JAXUCZ010000005.1  155724378-155724571
            228-327             JAXUCZ010000005.1  155724942-155725041
            328-481             JAXUCZ010000005.1  155726205-155726358
            482-641             JAXUCZ010000005.1  155728962-155729121
            642-785             JAXUCZ010000005.1  155732660-155732803
            786-863             JAXUCZ010000005.1  155734814-155734891
            864-1015            JAXUCZ010000005.1  155735359-155735510
            1016-1106           JAXUCZ010000005.1  155738870-155738960
            1107-1266           JAXUCZ010000005.1  155740995-155741154
            1267-1378           JAXUCZ010000005.1  155742543-155742654
            1379-1495           JAXUCZ010000005.1  155743955-155744071
            1496-3179           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3179
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..33
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            34..227
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    129..131
                     /gene="Hp1bp3"
                     /note="upstream in-frame stop codon"
     CDS             132..1793
                     /gene="Hp1bp3"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform a"
                     /protein_id="NP_001423781.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MATDMSQGELIHPKALPLIVGAQLIHADKLGEKADDSTMPIRRA
                     VNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPENETPPAPSREAEQPKGEPES
                     GEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLSASQLARAQKQTPMASSPRPK
                     MDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLERRGYLLKQALKRELNRGVIKQ
                     VKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVKLEDVLPLAFTRLCEPKEASY
                     SLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPL
                     LGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKN
                     GWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSEDEDEEEDEEESSEDSEDEEP
                     PPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRGKVRPLPKKAPPKAKTPARKG
                     RPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKKKSFKTKK"
     misc_feature    135..137
                     /gene="Hp1bp3"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); acetylation site"
     misc_feature    147..149
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    219..524
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    282..284
                     /gene="Hp1bp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    384..386
                     /gene="Hp1bp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    555..557
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    594..848
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    594..848
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    594..596
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    597..599
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    order(615..617,651..653,747..749,789..791)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(615..617,651..653,747..749,789..791)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    699..701
                     /gene="Hp1bp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q3TEA8; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); acetylation site"
     misc_feature    732..767
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    732..767
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    822..884
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    870..872
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    888..902
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: PxVxL motif.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5"
     misc_feature    921..1103
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    921..1103
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1149..1352
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1149..1352
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1395..1790
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1452..1454
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    1455..1457
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    1464..1466
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    <1536..>1760
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1536..>1760
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            228..327
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            328..481
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            482..641
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..785
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            786..863
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1015
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1106
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1266
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1378
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1495
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..3179
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgtgg ccgccattac ggagttccca gtggttgact cttcaccaca ctgaagccat
       61 taggaaaccc ctgtgattaa cagcagaggc ttcagagtct caccagtatt caggcctaga
      121 ctttatttta aatggcaact gatatgtctc aaggtgaact catccatcct aaggcactcc
      181 cacttatagt aggagctcag ctgatccacg cggacaagtt aggtgagaaa gcagacgata
      241 gcaccatgcc tatccgtcgg gctgtgaatt ctactcggga aactccgccc aaaagcaaac
      301 ttgctgaagg ggaagaagaa aaaccagaac cagatgggag ttcagaggag tctatctcta
      361 cggtagaaga accagagaat gagactccac ctgctccatc cagggaggca gagcagccca
      421 agggggagcc tgagagtgga gagaaggaag agagcaagtc tgctgaggaa accaagaaag
      481 aagagaagga tcagtctaaa gaaaaggaga agaaagtgaa gaaaaccatc cctgcctggg
      541 ccactctgtc tgccagccag ctagccaggg cccagaaaca aaccccaatg gcttcctccc
      601 cacggccaaa gatggatgca atcttaactg aggccattaa ggcatgcttc cagaagagcg
      661 gtgcctccgt ggttgctatc cggaagtaca tcattcataa gtacccttct ctggatctgg
      721 agagaagggg ctatctcctc aagcaagcac tgaaaagaga gttaaacaga ggagtcatca
      781 aacaggtaaa aggaaaaggt gcatctggca gttttgtcgt ggtccagaaa tcaaaaacac
      841 ctcagaaatc caaaaacaga aagaagggct ctgcagtgga tccagaacca caagtaaaac
      901 tggaagatgt tctcccattg gcttttaccc gactctgtga acctaaggaa gcctcctaca
      961 gtctcatcag gaaatacgtg tctcagtatt accctaagct tcgagtggac atcaggcccc
     1021 agttgttgaa gaatgctctg cagagagcag tggagagagg ccagttagag cagataactg
     1081 gcaagggtgc ttcggggaca ttccagctga agaaatccgg ggagaaaccc ctgcttggtg
     1141 gaagcctgat ggaatatgca atcttgtctg ccattgctgc catgaatgaa cctaagacct
     1201 gctccaccac tgctctgaag aagtatgtcc tggagaacca cccagggacc aattctaact
     1261 accaaatgca tttgctgaaa aaaactctgc agaaatgtga gaagaatggg tggctggagc
     1321 agatctctgg gaaggggttc agcggcacct tccagctgtg cttcccctat taccccagcc
     1381 caggagttct gtttccaaag aaagtgtcag atggctctga ggatgaggat gaggaggagg
     1441 atgaagagga gtcatcagag gactctgagg atgaagagcc gccacccaag aggagcttac
     1501 agaagaaaac accagccaag ccccaaggga agacggcctc catgaagcag agaggggcta
     1561 agcctgcgcg taaagtccct gctgcccaga gagggaaggt gaggccgctg cctaagaaag
     1621 ctccgcccaa ggctaagacc cctgccagga aaggcagacc cgcaccctca gccgtcaaga
     1681 agcctagcgg gagcacctcc aaaaagcctg tagccaatgc acgaaaggaa gcgaaactgc
     1741 ccggtaaggg caaatctgcc atgaagaaga agtctttcaa gacaaaaaag taaattttat
     1801 aggaaaaagg gtatcatgat tgaattcaga atcttatttt ataaggtcag tgtgcatttg
     1861 ttttagttat aatgctttta aattttacat ttttcttccc atacgaacac tgtgggaagg
     1921 aatgtaaaca aaccagtgta gacatttgtt ggcttaggtg ctgttctcag tgcctgcttc
     1981 ttcatcattt taatttctgc cgtaatcctg gacttggctg aactgtgtaa ctaccctgct
     2041 ccctttgttc atcttaaccc aaccctcatt ctcttctttt tgtgatccaa tttggggttt
     2101 tcttttcctc ctcgaagtta atccaaacag ttgcaaagat gcatttgtag tgagtacctc
     2161 caggtctggt gctgaagcca gacggagcgg gagcactaca gggacagcat tgcttcctgc
     2221 ctggggactt gctgattgac cctggctgtg aaatcactcc actaaccttt ctccagcgtg
     2281 ggccagggac attataactt tggaaagaag ccccagtctg ccatccatag attctgaaga
     2341 tctcttctcc tttgctgtct gcccagttgc caagcacgcc ctgctgccca gagcgttgtt
     2401 cccttaacag caagcgcacg tctgcgccac ctgctttctg actgaagggg aagtacagga
     2461 atatgtggaa tctgattgct tattaccaaa aatgacagaa tattcttgat caaaggccta
     2521 gatatatttt taatatttgg ggcatgagct tcccctgttt gagagttccc attactgagg
     2581 tagaaatgtt aatttgctaa acataatttg ctaaaatgac cagttttcag attcacctgt
     2641 gcgtgtgccc ccactcgcac cccaccccat tctctccata gaacgtttgc tgtcagctcg
     2701 gcggtctcca tttcgaggtg tttatcagaa gcgaggaggg gagcaaatga agccgtgctg
     2761 cccagccctc ctcgtcttgt atttgtttag gttgtgaggt tgtgtaaata gtagcttcct
     2821 acttgagaac tacagctcct gcttatcatt gatcctttcc tgtggcactt aatattttaa
     2881 ttgtcttaag cttttgatgt acatcctctg gccccttaca cgctgccaga ggagaaggtg
     2941 tttgagattc attccacttg aagtgtcttt cctgggctcc ccacagctgc agatggctgg
     3001 gaagtggact tgaggaatgg gctcgaattg gtggttcatg cctgtgagga cccatcatga
     3061 gtcatcggga tttgtgttgc atggaaggca atctttcctg ttgtaaatct tcctttttta
     3121 tgtacatata ttttgaaaat atgaataaac atgaaatttt aaaagctgct gaactacaa
//
LOCUS       NM_001436871            4471 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus calsyntenin 1 (Clstn1), transcript variant 2,
            mRNA.
ACCESSION   NM_001436871 XM_039110101
VERSION     NM_001436871.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4471)
  AUTHORS   Zhou,F., Hu,R., Wang,Y., Wu,X., Chen,X., Xi,Z. and Zeng,K.
  TITLE     Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models
  JOURNAL   Synapse 78 (5), e22307 (2024)
   PUBMED   39171546
  REMARK    GeneRIF: Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models.
REFERENCE   2  (bases 1 to 4471)
  AUTHORS   Ster,J., Steuble,M., Orlando,C., Diep,T.M., Akhmedov,A.,
            Raineteau,O., Pernet,V., Sonderegger,P. and Gerber,U.
  TITLE     Calsyntenin-1 regulates targeting of dendritic NMDA receptors and
            dendritic spine maturation in CA1 hippocampal pyramidal cells
            during postnatal development
  JOURNAL   J Neurosci 34 (26), 8716-8727 (2014)
   PUBMED   24966372
REFERENCE   3  (bases 1 to 4471)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   4  (bases 1 to 4471)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4471)
  AUTHORS   Vagnoni,A., Perkinton,M.S., Gray,E.H., Francis,P.T., Noble,W. and
            Miller,C.C.
  TITLE     Calsyntenin-1 mediates axonal transport of the amyloid precursor
            protein and regulates Abeta production
  JOURNAL   Hum Mol Genet 21 (13), 2845-2854 (2012)
   PUBMED   22434822
  REMARK    GeneRIF: findings show that amyloid precursor protein (APP) and
            calsyntenin-1 are co-transported through axons, that loss of
            calsyntenin-1 disrupts axonal transport of APP and that
            calsyntenin-1 loss also leads to altered APP processing and
            increased production of Abeta
REFERENCE   6  (bases 1 to 4471)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4471)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
  REMARK    GeneRIF: Calsyntenin-1 links a certain type of vesicular and
            tubulovesicular organelles to the Kinesin-1 motor.
REFERENCE   8  (bases 1 to 4471)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   9  (bases 1 to 4471)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4471)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110101.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21973.1,
                                           SRR26643297.21146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000005.1  165314338-165314634
            298-420             JAXUCZ010000005.1  165347091-165347213
            421-616             JAXUCZ010000005.1  165357948-165358143
            617-825             JAXUCZ010000005.1  165359104-165359312
            826-975             JAXUCZ010000005.1  165361662-165361811
            976-1161            JAXUCZ010000005.1  165362057-165362242
            1162-1410           JAXUCZ010000005.1  165364336-165364584
            1411-1532           JAXUCZ010000005.1  165364894-165365015
            1533-1695           JAXUCZ010000005.1  165367642-165367804
            1696-1752           JAXUCZ010000005.1  165370536-165370592
            1753-1910           JAXUCZ010000005.1  165372011-165372168
            1911-2059           JAXUCZ010000005.1  165372364-165372512
            2060-2286           JAXUCZ010000005.1  165372762-165372988
            2287-2457           JAXUCZ010000005.1  165373487-165373657
            2458-2603           JAXUCZ010000005.1  165373961-165374106
            2604-2739           JAXUCZ010000005.1  165375061-165375196
            2740-2924           JAXUCZ010000005.1  165375492-165375676
            2925-4471           JAXUCZ010000005.1  165376081-165377627
FEATURES             Location/Qualifiers
     source          1..4471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4471
                     /gene="Clstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
     exon            1..297
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3122
                     /gene="Clstn1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; alc-alpha; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 2 precursor"
                     /protein_id="NP_001423800.1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
                     /translation="MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGIIRS
                     KEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYK
                     AAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYG
                     KEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPS
                     IHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSS
                     FNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKE
                     TILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHH
                     FVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQEYSGVESGNETE
                     PVTMASAGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRG
                     VQIQTSSSQAVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAA
                     CIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPELKIISTITREV
                     EPEADGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEV
                     NHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKV
                     EVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVV
                     CVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSS
                     EEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY"
     sig_peptide     207..290
                     /gene="Clstn1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    327..653
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    327..653
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,525..527,531..533,642..644,648..653)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,525..527,531..533,642..644,648..653)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    678..950
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    678..950
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1269..>1607
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1269..>1607
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1272..1274
                     /gene="Clstn1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6Q0N0.1); glycosylation site"
     misc_feature    1872..2930
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    1872..2930
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    2646..2651
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     mat_peptide     2652..3119
                     /gene="Clstn1"
                     /product="CTF1-alpha. /evidence=ECO:0000250.
                     /id=PRO_0000323603"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1)"
     misc_feature    2733..2738
                     /gene="Clstn1"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26479776;
                     propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1); cleavage
                     site"
     misc_feature    2754..2816
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     transmembrane region"
     misc_feature    2919..3119
                     /gene="Clstn1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q0N0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            298..420
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..616
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..825
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..975
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1161
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1410
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1532
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1695
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1752
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1910
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2059
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2286
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2457
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2603
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2739
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2924
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..4471
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccgcc gccgccgcct ccagcgcagc gctgccgacg aggggagggc gcgcgcggcc
       61 cagcagcacg gcggctgccg ctcacatccc ggtgctcgcc gcgccgccca gccgctggcc
      121 cccggctgcc cgcacccctc tcggcgtccc gcgcgactcc ctgctgcttc cgcgtcgggc
      181 cggccgcggc gctccgagcc cgagcgatgc tgcgccgccc tgcgcccgcg ctggcccggg
      241 ctgtccggct gctgctggcg gggctgctgt acggcggcgg ggtctgggcc gcgcgagtta
      301 acaagcacaa gccatggctg gagcccacct accacgggat cgtcaccgag aacgataaca
      361 cggtgctgct cgaccccccc ctcatcgccc tggacaaaga ctcaccgctg cgctttgcag
      421 gtgagatttg tggctttaaa atccacgggc agaatgtccc cttcgatgcc gtggtagtgg
      481 ataagtccac gggtgaggga ataatccgat caaaagagaa actggactgt gagttgcaga
      541 aagactatac attcaccatc caggcctacg actgcgggaa gggacccgat ggcaccggtg
      601 tgaaaaaatc tcacaaagca accgtgcaca tccaggtgaa cgacgtgaat gagtacgccc
      661 ccgtgttcaa ggagaagtcg tacaaggcgg ccgtggtgga gggcaagcag cacggcagca
      721 tcctcagggt ggaggccgtg gatgcagact gctcgcccca gttcagccag atctgcagct
      781 atgagattct caccccagat gtgccgttca ctgtggacaa agacggttac atcaaaaaca
      841 cagagaagct taactacggc aaagagcatc agtataagct cactgtcacc gcctatgact
      901 gtgggaagaa aagagccacg gaggacgtcc tggtgaagat cagcgttaag cccacctgca
      961 gccccgggtg gcaaggctgg agcagcagaa ttgaatatga gcccggcaca ggcgctttgg
     1021 ccgtcttccc gagcatccac ttggagacct gcgacgagcc tgtcgcctct gtgcaggcca
     1081 cagtggagct ggagaccagc cacataggga aaggctgcga ccgagacacc tactccgaga
     1141 agtccctcca ccggctctgt ggggctgctg ctggtacctc agagctgctc ccgtcgccca
     1201 gtagctcctt caattggacc gtcggcctcc ccactgacaa cggccatgac agtgaccagg
     1261 tctttgagtt caatggcaca caggcggtgc ggatcccaga cggtgttgtg acccttgacc
     1321 ccaaagagcc ttttacaatt tccgtgtgga tgcggcatgg gccttttggc cggaagaagg
     1381 agacaattct ctgcagttcg gataaaacag atatgaaccg acaccattat tcgctctatg
     1441 tccacgggtg cagactcatt ttcctcctcc gtcaggaccc gtctgaggag aagaagtaca
     1501 ggcctgcgga gttccactgg aagctgaacc aagtctgtga tgaggattgg caccactttg
     1561 tcctcaatgt ggaagtccca agtgtgaccc tctatgtgga cggcgtctct catgagccct
     1621 tctccgtgac cgaggactac ccacttcatc caaccaaaat agaaactcag cttgtggtcg
     1681 gagcttgctg gcaagagtac tcaggagtcg aaagtggcaa tgagactgag cctgtgacga
     1741 tggcctctgc aggtggtgac ctgcacatga cgcagttttt ccgaggtaac ctggctggcc
     1801 tcacagtccg ttctgggaaa ctggcagata agaaagtgat cgactgtctg tacacctgca
     1861 aagaggggct ggacctgcag gtccctgagg atggcaacag aggggtgcag atccaaacaa
     1921 gctccagtca ggcggtattg accttggagg gggagaatgt cggagagttg gataaggcca
     1981 tgcagcacat ttcttacctc aactcaaggc agttccccac accaggcatc cgcaggctga
     2041 aaatcaccag caccgtcaag tgctttaatg aggcggcttg catcgaggtg cctccggtgg
     2101 agggctacgt gatggtttta cagccagaag aacccaagat cagcctgagt ggggtccacc
     2161 actttgcccg cgcagcttcc gagtttgaga gcccggaggg tgtttccctt ttccctgagc
     2221 tgaaaatcat aagcaccatc accagagagg tggagcccga ggcggacggg gctgaggacc
     2281 ccacagtgca agagtccctg gtgtcggagg agattgtgca cgacctggac acctgtgagg
     2341 tcacggtgga aggggaggag ctgaacgcag agcaggagag cctagaggtg gacgtggccc
     2401 gcctccagca gaagggcatc gaagtgaacc actctgacct gggcgtggtc ttcacaggtg
     2461 tggaaaccat ggcaagctac gaggaggttc tgcacctcct gcgctatcgg aattggcaca
     2521 ccaggtccct gctggaccgg aagttcaagc tcatttgctc ggaactaaat ggtcgttacc
     2581 tcagcaacga gttcaaggtg gaggtgaatg tgatccacac agccaacccc gtggaacacg
     2641 ctaatcacat ggccgcccag ccacagtttg tccaccctga acaccgatcc ttcgtggacc
     2701 tgtctggtca caacttggcc agtcctcacc catttgcagt tgtccccagc acggcgactg
     2761 tcgtgattgt ggtatgtgtc agcttcctgg ttttcatgat catcctgggg gtgtttcgga
     2821 tccgagctgc acatcagcga acgatgcggg accaggacac cgggaaggag aacgagatgg
     2881 actgggatga ctctgccttg accatcactg tcaaccccat ggagacgtac gaggaccagc
     2941 acagcagtga ggaggaggaa gaagaggaag aggaggagga gagtgaagac ggggaggagg
     3001 aggaggacat caccagtgcc gagtcagaga gcagtgagga ggaggaaggc ggccccgggg
     3061 acggccagaa caccacccgg cagcagcagc tagaatggga ctactccaca ctcagctact
     3121 aaacacgcgc tcgcccagca cctgctctcc agactctccc agccatcttc cagccccacg
     3181 ggtccacgat gtacaaatca ttttgaccag caggtctgca gacccctccc ccattgctga
     3241 aagtcctccc gtgcttggtg tgtgggacca caggctccgc cctccctgcc catcacgctt
     3301 gcagttttgc ttaggagctg gcccttcctc ccagtgcagg ggccccacag cacctcagac
     3361 cccaagtgtg tctggagtcc cctgtcagcc agggagagga caccagcacc tgggacctcc
     3421 agagaagccg cagtgagcgg acttgtcgac agagggtaaa aaattactcc cacgcagtca
     3481 tcatttttct tcatttttaa aagtttttat ttttattttc caatatagtg catgtataaa
     3541 gtgggagagc ggggaggggg ggttaatatg tagatgacca actgactttt taatattttg
     3601 taaataaatt gggattcttt gtgtcctttg tgctagtgta gtccaggaca ggaatgtgaa
     3661 gtcagaacat ggggccagga agagctcttc ctcccttttc cctcccaaga aaccaggttg
     3721 gaaaggtcca agtcacagtg gcccatgctg gggtttctgt acagccatgt ggccagggcc
     3781 ataggttttg agtgctgcct gggggagcca gacccacgcg ctcccaccac attagaggct
     3841 gggaacagcc aggatggtgc caaagcccct ggccttcctt gtacacgcct gtgaccagcc
     3901 tcgtggcttc tgctaattag cgtgtctccc tgttggtgaa aacctgtagc tgggaactga
     3961 tggcaaagat ggacaacagt tctgagcagt ctgcactaca gcacccaaga ggagaacctg
     4021 aggcccgaaa acaaactgct acaatgtttc aaaacgagct gcgctctcct ccccagagac
     4081 cccacgggat gcccccggga tgcccccttg ctgtcgggtt ttggctaaga cctaagaccc
     4141 agcagaggag agccagccgg cttggggggt gggggtgggg gaggagacag cagctaaaac
     4201 ccacacagca cggcttgtca ttcacagtca cagtttagac tcctccagct ggggaatccg
     4261 gtcctcgctg ctagtcctaa ggatgttgac gctgtgctgc ctgtggccac cctcccgtgt
     4321 cctgttccct gtagtcgctt tatagatgga aacaggctat gaagagggac actgtcgtgt
     4381 gttggtagcc gcaggctccc cttaagatgt gtatattgac cccaggtcag gaagtgtatg
     4441 cgttataata aagttctggt tctaactcca a
//
LOCUS       NM_001436910            3966 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus thymocyte selection-associated high mobility
            group box (Tox), transcript variant 4, mRNA.
ACCESSION   NM_001436910 XM_017593467
VERSION     NM_001436910.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3966)
  AUTHORS   Artegiani,B., de Jesus Domingues,A.M., Bragado Alonso,S.,
            Brandl,E., Massalini,S., Dahl,A. and Calegari,F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
REFERENCE   2  (bases 1 to 3966)
  AUTHORS   Yun,S., Lee,S.H., Yoon,S.R., Kim,M.S., Piao,Z.H., Myung,P.K.,
            Kim,T.D., Jung,H. and Choi,I.
  TITLE     TOX regulates the differentiation of human natural killer cells
            from hematopoietic stem cells in vitro
  JOURNAL   Immunol Lett 136 (1), 29-36 (2011)
   PUBMED   21126536
REFERENCE   3  (bases 1 to 3966)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   4  (bases 1 to 3966)
  AUTHORS   Aliahmad,P. and Kaye,J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
REFERENCE   5  (bases 1 to 3966)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   6  (bases 1 to 3966)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017593467.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1602773.1,
                                           SRR26360190.1790262.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000005.1  24967900-24968025   c
            127-262             JAXUCZ010000005.1  24967582-24967717   c
            263-328             JAXUCZ010000005.1  24822463-24822528   c
            329-571             JAXUCZ010000005.1  24803320-24803562   c
            572-853             JAXUCZ010000005.1  24722995-24723276   c
            854-1084            JAXUCZ010000005.1  24706495-24706725   c
            1085-1165           JAXUCZ010000005.1  24694150-24694230   c
            1166-1549           JAXUCZ010000005.1  24681968-24682351   c
            1550-1701           JAXUCZ010000005.1  24674144-24674295   c
            1702-3966           JAXUCZ010000005.1  24671564-24673828   c
FEATURES             Location/Qualifiers
     source          1..3966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3966
                     /gene="Tox"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
     exon            1..126
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            127..262
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    146..148
                     /gene="Tox"
                     /note="upstream in-frame stop codon"
     CDS             161..1738
                     /gene="Tox"
                     /note="thymocyte selection-associated HMG box"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_001423839.1"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
                     /translation="MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPVSQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMQEIGNAEGAQYSSHPQLAAMRP
                     RGQPTDLRQQASMMQHGQLTTINQSQLSAQLGLNMGGTNVPHNSPSPPGSKSATPSPS
                     SSVHEDECEDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYNDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQPLVQQPLASQLPM
                     QVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWST
                     DYCSSGGMQRDKALYLT"
     misc_feature    944..1153
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    944..1153
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    order(944..949,953..967,974..979,998..1000,1034..1039,
                     1046..1048,1055..1060,1079..1081,1091..1093,1100..1102,
                     1112..1114,1121..1123)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     misc_feature    order(944..949,953..967,974..979,998..1000,1034..1039,
                     1046..1048,1055..1060,1079..1081,1091..1093,1100..1102,
                     1112..1114,1121..1123)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     exon            263..328
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            329..571
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            572..853
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1084
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1165
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1549
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1701
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..3966
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttacct gcccggcggc gggccgagag cgccggggcc gagcggacca ggcaggctgc
       61 gcgctcggcg tggacgggtg cgcgccgcgg cttagggggg gagagttgag cacttttcca
      121 ccctctgaaa agaaaaggag ttgcttgatg tgagagtgaa atggacgtaa gattttatcc
      181 acctccagcc cagcccgctg ctgcgcccgc cgctccctgt ctgggacctt ctccctgcct
      241 ggacccctac tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc
      301 gagccaggac tatgtgccag tcagccagtc ctaccctggc ccaagtctgg aaagtgaaga
      361 ctttaacatc ccacccatta ctcctccctc actccctgac cactctctgg tgcacctgaa
      421 tgaggtggag tccggttacc actctctgtg tcaccccatg aaccacaatg gcctgcttcc
      481 attccatcca caaaacatgg acctgccaga gatcaccgtg tccaacatgc tgggccagga
      541 tggcacactg ctctccaatt ccatctctgt gatgcaagag attggaaatg ctgaaggagc
      601 tcagtacagt tcccatcctc agctggcagc catgaggccg agaggccagc ctacagacct
      661 cagacagcag gcaagcatga tgcagcacgg ccagctgacc accatcaacc agtcacagct
      721 gagcgcacag ttgggcttga acatgggagg aaccaacgtc ccacacaact ccccttctcc
      781 acctgggagc aagtctgcaa ccccttcgcc ttccagctcg gtgcatgagg atgagtgtga
      841 ggatacctcc aagatcaatg gaggagagaa gcggcctgcc tctgatatgg gaaaaaaacc
      901 aaaaactcct aaaaagaaga agaagaagga tcctaatgag ccccagaagc ctgtgtctgc
      961 ctatgctttg ttctttcgtg atacccaggc tgccatcaag ggccaaaatc caaatgctac
     1021 ttttggtgaa gtctctaaga ttgtggcatc catgtgggat ggcctaggag aagagcagaa
     1081 acaggtctac aagaagaaaa ctgaggctgc aaaaaaggaa tacctgaagc agctagcagc
     1141 atacagagcc agccttgtat ccaagagcta caatgaccct gtggatgtta agacatctca
     1201 gccaccccag ctggtcaact ccaagccgtc agtgttccat gggcccagcc aggcccactc
     1261 agctctgtac ctaagttctc actatcacca acaaccagga atgactcctc agctcaccgc
     1321 catgcatccg agcctcccca gaaacatagc acctaagccc aataaccaaa tgccagtgac
     1381 tgtctccata gccaacatgg ctgtgtcccc accaccgccc ctccaaatca gcccacctct
     1441 tcatcagcat ctcagcatgc agcagcatca gccacttgtg cagcagcctc ttgcgagtca
     1501 gctccccatg caggtccaga ccgccttaca ctcgcccacc atgcagcaag gatttactct
     1561 ccaacccgac tatcagacta ttatcaaccc tacatctaca gccgcacaag ttgtcaccca
     1621 agcgatggag tacgtgcgtt ctgggtgcag aaatcctccc ccacagccgg tggactggag
     1681 taccgactac tgcagtagtg ggggcatgca gagggacaaa gcgctgtacc tcacctgaaa
     1741 atctcaacac ctctcctttc cactgaggaa ttcagggaaa ccttttcacc acggattgct
     1801 ttggccgctc aaagcagttc ttcattttat tagaaaatac aagttgctaa gcacttagga
     1861 ccatgtgagc ttgtgggtca cccacgctgg aagaaatagt catgcttctt tattattttt
     1921 ttaatctttt atggacattg tccctcttcc ctgaaggaag tatgggccat tcagatttct
     1981 gttggttttg ctgtgaagtg ctgccgctct agtaactgcc ttagcaacgg tagatgtctg
     2041 gggtaaaacg gtcctgggtt ttccattggt tttcataatg ggtgtttata tgaaactact
     2101 aaagactttt taaatggctt gatgtagcag tcatagcaag tttgtaaata gcatatatgt
     2161 tacactctcc tagagtataa aatgtgaatg tttttgtagc taaattgtaa tttgaaactg
     2221 gctcacccca gtttgttgat ttcagagggg ttaaattggc aaacattcat atttttactt
     2281 catttttaaa aagaaaaaaa acaactgact gatagttcta tattttcaaa agacttgaaa
     2341 actattccca aatcatttta atttaaaaac aaattggctt tgtcttattg atcagacaaa
     2401 aggaagctct cgtgtggagg gaagcgcaaa cacatttatt ttgtattgca ggaaaaaaat
     2461 tcttttttgt atcacttttg tgtaatggtt agtaagcgtc atctaagtcc ttttatgtat
     2521 aaaactgcca aatgctcgcc tggtatctta gctgcagaaa caggtcaaac agcgctaagt
     2581 gatcaccgtt acctgtggct ctgtgttact gttccctcat ccgtgtctgt atttaatcgt
     2641 tttcttctct ttttttttta atgaaacttg tttcgcttat ttatgaaata ataaatatag
     2701 gtgtttgtaa gtaaatttgt tagtatttga aagaggtttt gttgatgctt taatttttgc
     2761 tggcaaaaaa gaaaaaaaat ccatgcttgg tgtgaatatt tagtttttac agtgacatga
     2821 ataaaaccaa aactgctttt catttagtag caaaatagag tgacgaatct gtatttttgc
     2881 atatcttttg ttgacataaa tgaaaaacaa ttctacttag ccatcttctt ctcttgaaca
     2941 atacaacaga aaattgccct ggagatctca cacttgccaa gcctaagcaa acaccagtgc
     3001 atcccgttcc taaaaagata cgaagagcta tttttcactt ctccattcca aaacatttaa
     3061 ccaccaccac cacaccacac acacccgcta aaaaccaaat tcaagttgag tcactcaaaa
     3121 ttcctcaagc cacatgcttc tcatagcatg cagaaaacat ttaagaattg accaagggtt
     3181 caggaagagg tcaaagaagg atatcatgtc taggatcaat ctagaaatga aggactagta
     3241 accagatcag ctatagaaat aggaaaaaca tggaaaccgg aagcagttgc tagaaactgt
     3301 gaaatctgct gtccctctcc cctctactct cttcttcctc ttctatgcat cctgagtccc
     3361 tgtaagagat ttgcctgaag gtgtttgcat agttctgata gcagaaggga agggtgagga
     3421 aatgtttccc ttccacgggc ttctgtcacg taaattcatc tggctggaca tgaagagaat
     3481 gattgttttg cggaatgaaa taacctcaac aatttaaata caaatatatc atgtaatcca
     3541 gtcaaaatta aaaagacaaa agtcttgctt gctttggatt ggtttttcag acactgtgcg
     3601 agttgaatca cttggcatgt aatgactaat aaataatgca cattcagtgt tattattaaa
     3661 atggccgggg tcgagagctc aaattttcct gtcttgatac tgtataagaa ttcgtgtgat
     3721 taacttccca gtttattgtt tggctgttta gtattttaga aatataccag cattattaat
     3781 taactaatgc cttttattat tgtattatga taaaatatta ctttctccta cattaagtcc
     3841 aaactgagaa gagtccgacc agctaagata agaggtgtat caggagattg tctgcagctt
     3901 ttcctggcag gcgaaaagaa aaaaatacat caaatgtgaa ataaattatc aattaaactc
     3961 tcactg
//
LOCUS       NM_001436900            2650 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus caspase 3 (Casp3), transcript variant 3, mRNA.
ACCESSION   NM_001436900
VERSION     NM_001436900.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Niedermeyer,S., Yun,X., Trujillo,M., Jiang,H., Andrade,M.R.,
            Kolb,T.M., Suresh,K., Damarla,M. and Shimoda,L.A.
  TITLE     A novel interaction between aquaporin 1 and caspase-3 in pulmonary
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L638-L645 (2024)
   PUBMED   38375595
  REMARK    GeneRIF: A novel interaction between aquaporin 1 and caspase-3 in
            pulmonary arterial smooth muscle cells.
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   Holota,R., Decmanova,V., Alexovic Matiasova,A., Kosuth,J.,
            Slovinska,L., Pacut,L., Tomori,Z., Daxnerova,Z. and Sevc,J.
  TITLE     Cleaved caspase-3 is present in the majority of glial cells in the
            intact rat spinal cord during postnatal life
  JOURNAL   Histochem Cell Biol 161 (3), 269-286 (2024)
   PUBMED   37938347
  REMARK    GeneRIF: Cleaved caspase-3 is present in the majority of glial
            cells in the intact rat spinal cord during postnatal life.
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Galichanin,K. and Yu,Z.
  TITLE     Expression of active caspase 3 in the rat lens after in vivo
            exposure to subthreshold dose of UVR-B
  JOURNAL   BMC Ophthalmol 24 (1), 29 (2024)
   PUBMED   38254051
  REMARK    GeneRIF: Expression of active caspase 3 in the rat lens after in
            vivo exposure to subthreshold dose of UVR-B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Li,C., Zhang,H., Mo,J., Zuo,J. and Ye,L.
  TITLE     Caspase-3/GSDME dependent pyroptosis contributes to offspring lung
            injury induced by gestational PFOS exposure via PERK/ATF4 signaling
  JOURNAL   Arch Toxicol 98 (1), 207-221 (2024)
   PUBMED   37955688
  REMARK    GeneRIF: Caspase-3/GSDME dependent pyroptosis contributes to
            offspring lung injury induced by gestational PFOS exposure via
            PERK/ATF4 signaling.
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Vito,P., Ghayur,T. and D'Adamio,L.
  TITLE     Generation of anti-apoptotic presenilin-2 polypeptides by
            alternative transcription, proteolysis, and caspase-3 cleavage
  JOURNAL   J Biol Chem 272 (45), 28315-28320 (1997)
   PUBMED   9353287
REFERENCE   7  (bases 1 to 2650)
  AUTHORS   Ni,B., Wu,X., Du,Y., Su,Y., Hamilton-Byrd,E., Rockey,P.K.,
            Rosteck,P. Jr., Poirier,G.G. and Paul,S.M.
  TITLE     Cloning and expression of a rat brain interleukin-1beta-converting
            enzyme (ICE)-related protease (IRP) and its possible role in
            apoptosis of cultured cerebellar granule neurons
  JOURNAL   J Neurosci 17 (5), 1561-1569 (1997)
   PUBMED   9030616
REFERENCE   8  (bases 1 to 2650)
  AUTHORS   Juan,T.S., McNiece,I.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Fletcher,F.A.
  TITLE     Molecular characterization of mouse and rat CPP32 beta gene
            encoding a cysteine protease resembling interleukin-1 beta
            converting enzyme and CED-3
  JOURNAL   Oncogene 13 (4), 749-755 (1996)
   PUBMED   8761296
REFERENCE   9  (bases 1 to 2650)
  AUTHORS   Liu,X., Kim,C.N., Yang,J., Jemmerson,R. and Wang,X.
  TITLE     Induction of apoptotic program in cell-free extracts: requirement
            for dATP and cytochrome c
  JOURNAL   Cell 86 (1), 147-157 (1996)
   PUBMED   8689682
REFERENCE   10 (bases 1 to 2650)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.532354.1,
                                           SRR26643299.58847.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000016.1  52413320-52413549   c
            231-298             JAXUCZ010000016.1  52405106-52405173   c
            299-423             JAXUCZ010000016.1  52402552-52402676   c
            424-552             JAXUCZ010000016.1  52400663-52400791   c
            553-728             JAXUCZ010000016.1  52399499-52399674   c
            729-849             JAXUCZ010000016.1  52398718-52398838   c
            850-2650            JAXUCZ010000016.1  52395539-52397339   c
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2650
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="caspase 3"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
     exon            1..230
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    51..53
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="upstream in-frame stop codon"
     exon            231..298
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1079
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /EC_number="3.4.22.56"
                     /note="IRP; SCA-1; CASP-3; CPP-32; apopain; cysteine
                     protease CPP32; SREBP cleavage activity 1; protein Yama;
                     Caspase 3, apoptosis related cysteine protease (ICE-like
                     cysteine protease); CPP32beta; cysteine protease p32-beta"
                     /codon_start=1
                     /product="caspase-3"
                     /protein_id="NP_001423829.1"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
                     /translation="MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEM
                     GLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDS
                     VSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFII
                     QACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQS
                     LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFY
                     H"
     misc_feature    246..248
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    276..278
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P70677; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    321..323
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); phosphorylation site"
     mat_peptide     330..770
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p17.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004591"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     misc_feature    354..1076
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    354..1076
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    order(435..437,609..611,726..728,747..749,855..872,
                     882..887)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(435..437,609..611,726..728,747..749,855..872,
                     882..887)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(606..608,732..734)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(606..608,732..734)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(750..752,810..815,834..836,843..845,852..854,
                     921..923,945..947,963..965,1023..1025,1038..1043,
                     1047..1049,1056..1061)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(750..752,810..815,834..836,843..845,852..854,
                     921..923,945..947,963..965,1023..1025,1038..1043,
                     1047..1049,1056..1061)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(753..755,807..809)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(753..755,807..809)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     mat_peptide     771..1076
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p12.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004592"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     exon            299..423
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            424..552
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            553..728
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            729..849
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            850..2650
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcttgctc aggcaagcac tgaaggcaga gaagctggaa acagcgccgg tagcgtggtc
       61 tggagctggg agcccagacc cgggaggcca agctggtgtc cctaaacctg ggtgaaccgg
      121 ggcaggactc agaccctcga atatggcgca ggggccgcgc cgaggcgcaa aaggcggagt
      181 ccggggatcc ggagattgcc ctgggcaccg agcttcaggg gtgggagggg cgaagaaaag
      241 tgaccatgga caacaacgaa acctccgtgg attcaaaatc cattaataat tttgaaacaa
      301 agactatcca tggaagcaag tcgatggact ctggaatata tctggacagc agttacaaaa
      361 tggattaccc tgaaatgggc ttgtgtataa taattaataa taagaacttc cataaaagca
      421 ctggaatgtc agctcgcaat ggtaccgatg tcgatgcagc taacctcaga gagacattca
      481 tggccctgaa atacgaagtc aggaataaaa atgaccttac tcgtgaagaa attatggaat
      541 tgatggatag tgtttctaag gaagatcaca gcaaaaggag cagttttgtg tgtgtgattc
      601 taagtcatgg agatgaagga gtaatttttg gaacgaacgg acctgtggac ctgaaaaaac
      661 taactagttt cttcagaggc gactactgcc ggagtctgac tggaaagccg aaactcttca
      721 tcattcaggc ctgccgaggt acagagctgg actgcggtat tgagacagac agtggaactg
      781 acgatgatat ggcatgccag aagataccag tggaggccga cttcctgtat gcttactcta
      841 ccgcacccgg ttactattcc tggagaaatt caagggacgg gtcatggttc atccagtcac
      901 tttgcgccat gctgaaactg tacgcgcaca agctggaatt catgcacatc ctcactcgtg
      961 ttaaccggaa ggtggccacg gaatttgagt ccttctccct ggacgccact ttccatgcaa
     1021 agaaacagat cccgtgtatt gtgtcaatgc tcacaaaaga actgtacttt tatcactaaa
     1081 ggaatgactg ggagtggggt aggggcatgt ttctgttttg gttttttttt ttggtttttg
     1141 ttttttgttt tttttttttt atttgaatgc caaatgagaa aactgtcagg gagacttttt
     1201 ttttcccctc tcatttaaat caaatccgat gttccaggtc gtcattgaac aataccactg
     1261 cctgcaatgc agccacaata caatacctca gctttgatat caggtagttg aaatgaaatt
     1321 taattaggaa caaataaatg tcaataatgg tacaaccatc atagaagaaa ttggaaagtc
     1381 acactttggt aattagagag atttggtgcc actatgaatt tgaaattacg aagcagtgat
     1441 gatcttatac cccctcctca catctagaat gtcactttag ttttcgttaa gcataggaac
     1501 gataatgtca agtggtatgt cttagaactt gaatccacga gcagagtcaa aggctggttt
     1561 tggaactgat ctgtggaaat gaagagttgg agcactgtag cacacattat agctactggt
     1621 tttgtgacag ttgaccaggt cacatattta ttatttaaga caaaagtcgt gttttattat
     1681 tggaacaaaa ataactttat atgagaggaa aaccatgtgt gaacttggtt ggcttgttga
     1741 aggctaccat ccttcagtgg tggacatgac gacagggtgc tacgatccac cagcatttgt
     1801 ttcttactta ttcttatgca aatcagccta attttacaga ccagcaaaat atctaaagag
     1861 cgattatgca gcagcctcaa attgttgact attagaatgg aataaaggaa ttctacagga
     1921 acagaccata ataccagctg tcagtcagag cgtaaggaaa ggagaggtgg catctcctgt
     1981 gattggagag aagatggttt gagccggagc agagccatgg gcacgtcttc agaaaaggcc
     2041 tgctagttgg acccaccttg tgagcactgg tctgtgtgga tgatgtccaa gttaccacat
     2101 gagactgaac cagatcagaa gctcctgcaa aaaggctttc ccagagtgct gagcatctca
     2161 agaaagttca ctggactcca tgtacagagt ctgtagcatg ctgacttttc tgttgaagtt
     2221 tacaatgaaa ggaaaatgat ggtgatattt gtaccgtcac tagaaatgaa gggccctggc
     2281 acacgggact tggaaagcat ccagcaatag gccctgcagc ccatgtggag gagctgcaga
     2341 ctggagtcca cccctcctcc ccatcagggc gtctgtgctc caggcttcct taatcatgga
     2401 ggtgctgagt catcgctggc tctccctgtg ggtccagcat ttcccataag cctccttatt
     2461 gcacaaagaa aggaaggaac tcacattata actgatagta ggttcttgtt tagactggat
     2521 ttactgttaa ctcttttcta agtaaataca gcatgtggtg gtattttaaa atgtgttccc
     2581 atgtgacaat tttataaaag tcagatatct tgcattttta tttcaaaaca taaattcaga
     2641 tttaaaatta
//
LOCUS       NM_001436885            2861 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 11, mRNA.
ACCESSION   NM_001436885 XM_063275497
VERSION     NM_001436885.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275497.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.274648.1,
                                           SRR26360172.1021774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1732           JAXUCZ010000016.1  17498298-17498369
            1733-1856           JAXUCZ010000016.1  17503674-17503797
            1857-1907           JAXUCZ010000016.1  17504488-17504538
            1908-2044           JAXUCZ010000016.1  17505392-17505528
            2045-2105           JAXUCZ010000016.1  17508313-17508373
            2106-2188           JAXUCZ010000016.1  17509056-17509138
            2189-2321           JAXUCZ010000016.1  17518938-17519070
            2322-2861           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2861
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2332
                     /gene="Eps15l1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 11"
                     /protein_id="NP_001423814.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     DDPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVT
                     DPFGGDPFKESDPFHSSTSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSS
                     SSISSKGSDPFGTLDPFGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFK
                     SKQDTPALPPKKPAPPRPKPPSVWQ"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1732
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1907
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2044
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2105
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2188
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2321
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2861
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggatgatcc
     1741 tttcaaaaac aaagccttgt tgtttagcaa caactctcaa gagctgcatc cagacccctt
     1801 ccaggcagag gaccccttca agtctgaccc atttaaagga gctgatccct tcaaaggtga
     1861 ccctttccag agtgatccct tctcagagca gcagacagca gttacagacc catttggagg
     1921 ggaccctttc aaagaaagtg acccattcca tagctcaacc agtgatgact tcttcaagaa
     1981 acagacaaag aatgacccgt ttacctcaga ccccttcaca aagaaccctt ccttaccttc
     2041 aaagctcgac ccattcgagt ccagtgatcc cttctcatcc tccagcatct cctcgaaagg
     2101 ttcagatccc ttcggaacac tagacccctt tggaagcagc tccttcagca gtgccgaggg
     2161 tttcgctgac ttcagtcaga tgtccaagcc cccaccttct ggccccttct cctcctcctt
     2221 gggaggcaca ggattctcag atgacccctt taaaagtaaa caggacactc ctgctctgcc
     2281 tccgaagaag cccgctcctc cacggcccaa accgcccagc gtttggcaat gaggagcagc
     2341 agctggcctg ggccaaacgg gagagtgaga aagcggagca ggagcggctg gcgaggcttc
     2401 ggcgacagga acaggaggac ctggagctgg ccatcgccct cagcaaggcc gatatgccgg
     2461 cctaggtgac acaggggaag ccgcagctgt ctgtatgtcc acatcatgct cagagcgtgc
     2521 ccccttcaag ccaagccatg ccacagccaa ggacagctgg ccacagggcc tcaggccaca
     2581 gggaccttgt tgagaggtag cagacacagc ccacgcctgt gggtgggcca ggaaggcagc
     2641 cttcggtaaa aggcctggaa cctgcctgtc tctgaggtgt cagtcaggct cttccttcca
     2701 atcattcagt gactgacgga gaaggcctcc agtctcctag ctacagacaa gctccacccc
     2761 aacccttcct cacatccaca agacaccctg cacacatgat gtatgcattc gttgtataaa
     2821 aatgaagttt gaatgattaa tataaaatat tttaatacaa a
//
LOCUS       NM_001029921            3067 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 4, mRNA.
ACCESSION   NM_001029921 XM_341407
VERSION     NM_001029921.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001029921.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098004.1, SRR26360194.1809503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1732           JAXUCZ010000016.1  17498298-17498369
            1733-1856           JAXUCZ010000016.1  17503674-17503797
            1857-1907           JAXUCZ010000016.1  17504488-17504538
            1908-2044           JAXUCZ010000016.1  17505392-17505528
            2045-2105           JAXUCZ010000016.1  17508313-17508373
            2106-2188           JAXUCZ010000016.1  17509056-17509138
            2189-2321           JAXUCZ010000016.1  17518938-17519070
            2322-2527           JAXUCZ010000016.1  17531082-17531287
            2528-3067           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3067
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2671
                     /gene="Eps15l1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 4"
                     /protein_id="NP_001025092.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     DDPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVT
                     DPFGGDPFKESDPFHSSTSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSS
                     SSISSKGSDPFGTLDPFGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFK
                     SKQDTPALPPKKPAPPRPKPPSGQSTPVSQLGSSAFPESPDPFQPLEADSGDPFQNKK
                     GFGDPFSGKDPFAPSSSAKPPKASSSGFADFTSFGNEEQQLAWAKRESEKAEQERLAR
                     LRRQEQEDLELAIALSKADMPA"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1732
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1907
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2044
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2105
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2188
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2321
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2527
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..3067
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggatgatcc
     1741 tttcaaaaac aaagccttgt tgtttagcaa caactctcaa gagctgcatc cagacccctt
     1801 ccaggcagag gaccccttca agtctgaccc atttaaagga gctgatccct tcaaaggtga
     1861 ccctttccag agtgatccct tctcagagca gcagacagca gttacagacc catttggagg
     1921 ggaccctttc aaagaaagtg acccattcca tagctcaacc agtgatgact tcttcaagaa
     1981 acagacaaag aatgacccgt ttacctcaga ccccttcaca aagaaccctt ccttaccttc
     2041 aaagctcgac ccattcgagt ccagtgatcc cttctcatcc tccagcatct cctcgaaagg
     2101 ttcagatccc ttcggaacac tagacccctt tggaagcagc tccttcagca gtgccgaggg
     2161 tttcgctgac ttcagtcaga tgtccaagcc cccaccttct ggccccttct cctcctcctt
     2221 gggaggcaca ggattctcag atgacccctt taaaagtaaa caggacactc ctgctctgcc
     2281 tccgaagaag cccgctcctc cacggcccaa accgcccagc ggtcagagta cacctgtaag
     2341 ccagctgggt tcttcagcct tccctgaatc ccctgatcca ttccagccac tcgaggctga
     2401 cagcggcgac ccgttccaaa ataaaaaggg gtttggggac ccatttagtg gcaaagatcc
     2461 atttgcccct tcctcttcag ctaaacctcc taaggcctct tcttccggct ttgccgactt
     2521 cacctctttt ggcaatgagg agcagcagct ggcctgggcc aaacgggaga gtgagaaagc
     2581 ggagcaggag cggctggcga ggcttcggcg acaggaacag gaggacctgg agctggccat
     2641 cgccctcagc aaggccgata tgccggccta ggtgacacag gggaagccgc agctgtctgt
     2701 atgtccacat catgctcaga gcgtgccccc ttcaagccaa gccatgccac agccaaggac
     2761 agctggccac agggcctcag gccacaggga ccttgttgag aggtagcaga cacagcccac
     2821 gcctgtgggt gggccaggaa ggcagccttc ggtaaaaggc ctggaacctg cctgtctctg
     2881 aggtgtcagt caggctcttc cttccaatca ttcagtgact gacggagaag gcctccagtc
     2941 tcctagctac agacaagctc caccccaacc cttcctcaca tccacaagac accctgcaca
     3001 catgatgtat gcattcgttg tataaaaatg aagtttgaat gattaatata aaatatttta
     3061 atacaaa
//
LOCUS       NM_001436888            3065 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 14, mRNA.
ACCESSION   NM_001436888 XM_063275501
VERSION     NM_001436888.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275501.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3177135.1,
                                           SRR26360181.737804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1732           JAXUCZ010000016.1  17498298-17498369
            1733-1856           JAXUCZ010000016.1  17503674-17503797
            1857-1907           JAXUCZ010000016.1  17504488-17504538
            1908-2044           JAXUCZ010000016.1  17505392-17505528
            2045-2105           JAXUCZ010000016.1  17508313-17508373
            2106-2188           JAXUCZ010000016.1  17509056-17509138
            2189-3065           JAXUCZ010000016.1  17514185-17515061
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3065
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2290
                     /gene="Eps15l1"
                     /note="isoform 14 is encoded by transcript variant 14;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 14"
                     /protein_id="NP_001423817.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     DDPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVT
                     DPFGGDPFKESDPFHSSTSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSS
                     SSISSKGSDPFGTLDPFGSSSFSSAEGFADFSQMSKSPRQEELRVCRHKLQKEVGSPT
                     CLTIQKCPLSL"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1732
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1907
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2044
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2105
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2188
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..3065
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggatgatcc
     1741 tttcaaaaac aaagccttgt tgtttagcaa caactctcaa gagctgcatc cagacccctt
     1801 ccaggcagag gaccccttca agtctgaccc atttaaagga gctgatccct tcaaaggtga
     1861 ccctttccag agtgatccct tctcagagca gcagacagca gttacagacc catttggagg
     1921 ggaccctttc aaagaaagtg acccattcca tagctcaacc agtgatgact tcttcaagaa
     1981 acagacaaag aatgacccgt ttacctcaga ccccttcaca aagaaccctt ccttaccttc
     2041 aaagctcgac ccattcgagt ccagtgatcc cttctcatcc tccagcatct cctcgaaagg
     2101 ttcagatccc ttcggaacac tagacccctt tggaagcagc tccttcagca gtgccgaggg
     2161 tttcgctgac ttcagtcaga tgtccaagtc cccaaggcag gaggagttga gagtctgtag
     2221 acataagctt cagaaagagg tgggatcgcc cacatgcctc acgatacaga agtgtcctct
     2281 tagcctgtga ggacccatct tgggagccct cccccagtgg atgcctgacc ctgtgttcac
     2341 tgctcccttt gcacttctgg aaaagcatga cttgtaaaca aggaacagtt ggcaagtgga
     2401 agagtcacag catgctgcag taaaagttat ttcagactca ggaactgttt ttctggaacc
     2461 ttttcctctt catgttctca gcatgatgga ccatgacatg acaaggtggg gcagctgtag
     2521 tcactgtgcc atctctgctg gtctgtccgt cacagtacag atggggaagc aagcaaggca
     2581 caggcagttg gactgggatt tcagcccagg ttgagtaacc cagctcacct ctgaccacag
     2641 gggcctgcag cctgaccagg atgatctgga aacttccgtg gacaagcttt gaattaagat
     2701 tctgccattt gtgtataaag acttgagagt gttcttagta gagtctctac tcctccctgc
     2761 tctgcagcct gacagcccgc caggccttcc tgcatgaagc tcctagctct acagaataag
     2821 gatttggggg cgggggaggg ggggtctggt taggtctgtg aatctagagg ggtgggggtg
     2881 ggggctggag agatggctca gtggttaaga gcactgactg ctcttccaga ggtcctgagt
     2941 tcaattccca gcaaccacat ggtggctcac aaccatctgt aatgggacct gatgccctct
     3001 tctggtgtgt ctgaagacag ccacaatgta tttatatata ataaataaat ctgtttttaa
     3061 aaaga
//
LOCUS       NM_001436930            5945 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3),
            transcript variant 4, mRNA.
ACCESSION   NM_001436930 XM_039092047
VERSION     NM_001436930.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5945)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 5945)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 5945)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 5945)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 5945)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 5945)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039092047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.49476.1,
                                           SRR26643296.33374.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  83684312-83684495   c
            185-320             JAXUCZ010000014.1  83674558-83674693   c
            321-369             JAXUCZ010000014.1  83628633-83628681   c
            370-454             JAXUCZ010000014.1  83627427-83627511   c
            455-532             JAXUCZ010000014.1  83614191-83614268   c
            533-622             JAXUCZ010000014.1  83611592-83611681   c
            623-739             JAXUCZ010000014.1  83611102-83611218   c
            740-822             JAXUCZ010000014.1  83604938-83605020   c
            823-989             JAXUCZ010000014.1  83602356-83602522   c
            990-1086            JAXUCZ010000014.1  83592224-83592320   c
            1087-1200           JAXUCZ010000014.1  83588725-83588838   c
            1201-1406           JAXUCZ010000014.1  83583226-83583431   c
            1407-1538           JAXUCZ010000014.1  83582300-83582431   c
            1539-1650           JAXUCZ010000014.1  83581721-83581832   c
            1651-1846           JAXUCZ010000014.1  83575932-83576127   c
            1847-2032           JAXUCZ010000014.1  83575039-83575224   c
            2033-2203           JAXUCZ010000014.1  83574230-83574400   c
            2204-2349           JAXUCZ010000014.1  83572847-83572992   c
            2350-3754           JAXUCZ010000014.1  83570317-83571721   c
            3755-3843           JAXUCZ010000014.1  83568438-83568526   c
            3844-3870           JAXUCZ010000014.1  83567729-83567755   c
            3871-5945           JAXUCZ010000014.1  83564065-83566139   c
FEATURES             Location/Qualifiers
     source          1..5945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5945
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..184
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..320
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..369
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..454
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..532
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    515..517
                     /gene="Mtmr3"
                     /note="upstream in-frame stop codon"
     CDS             530..4042
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="isoform 4 is encoded by transcript variant 4;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 4"
                     /protein_id="NP_001423859.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MDEEMRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEY
                     VGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFP
                     TFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRN
                     SCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWL
                     DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNM
                     VPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQE
                     PQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVE
                     NIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSE
                     SGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAP
                     CALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSH
                     QLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQR
                     LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVMTRWLPDHLAAHC
                     YACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSC
                     YSSLHPTSSSIDLELDKPIAATSN"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    3761..3970
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    3761..3970
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    order(3764..3766,3773..3775,3827..3844,3875..3880,
                     3950..3958)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     misc_feature    order(3764..3766,3773..3775,3827..3844,3875..3880,
                     3950..3958)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     exon            533..622
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..739
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..989
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1086
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1200
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1406
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1538
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1650
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1846
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2032
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2203
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2349
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3754
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3843
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3870
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..5945
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccgc tgccgccatg ttgttgtggt tgtgagaagg cggcggcggc agcggtggcg
       61 gcggagcagc cggtggagac gctccagcgg cccaggcgct gccccccgcc gaccctggct
      121 ggcagcctcc tggggtggcg gaggaggccg tgcggtggcg ggcctcgcca tgtcctgcct
      181 cccgagtacc tggtgacctg ttttgactct ccatttggaa gggcctggtc tgtaccattg
      241 taaacatgct ttaccgagtt gtgatgactg ctcctcctcc ttgtttttgg cctgggaact
      301 gagcccaagg tcttatccag atttccttgt aaaaccttgt agaagaaaaa gttctcagga
      361 agatacttgt gcatcggagt cagaggctgg tgcaagctgg ctagccagag aaccaaatca
      421 gtgaaccccc agttctacag cagatcctgc cttagtctca agcagaagag aaagaagaac
      481 cttgtcagag actggagaag gacggggtct ctcctgacct ggtctggtca tggatgaaga
      541 gatgcggcat agccttgagt gcatccaggc caatcagatc tttcccagga agcagctgat
      601 tcgggaggat gaaaatcttc aggttccttt ccttgaactc catggagaga gcacagagta
      661 tgtgggccgt gctgaggatg ccatcattgc cctctctaat tacagacttc acatcaagtt
      721 taaggagtct cttgtgaatg ttccattaca gcttatagaa agcgttgaat gccgtgatat
      781 atttcagctt cacttgacat gcaaagactg caaagttatc aggtgtcagt tcccaacctt
      841 tgagcagtgt caagattggc ttaagagatt aaacaatgca atccgaccac ctggaaaaat
      901 agaagatctc ttctcatttg cataccatgc ttggtgcatg gaggtctatg ccagtgaaaa
      961 agagcagcat ggagacctgt gcagaccagg ggaacatgta acgtcaaggt ttaagaatga
     1021 agtggagcgg atgggttttg atatgaacaa tgcctggagg atttccaaca tcaatgagaa
     1081 atacaaatta tgtggtagtt atccacaaga gctcatagta cctgcctgga tcactgacaa
     1141 agaactagaa agcgtggcag gcttcagatc ctggaagcgc atccccgccg tcatctacag
     1201 gcaccagagc aatggagccg tcattgcccg ctgcggacag cccgaggtta gctggtgggg
     1261 ctggcggaat gctgatgatg aacatctggt gcagtcagtg gccaaggctt gtgcttctga
     1321 ctctcagtca agtgttggca aggtttccac tcggaacagt tgtcggggct ttcccaatgc
     1381 aggggatctt tctgatgtgg agttcgatgc ctctctgtca aatgcttcag gaacagaaag
     1441 tttagctctc cagccacaga agcttttgat cttggacgca cgctcctatg cagcagctgt
     1501 ggcaaatcga gccaaaggag ggggctgtga gtgtccagag tattatccaa actgtgaagt
     1561 tgtgtttatg ggaatggcaa acatacattc tatccggagg agtttccagt ctctgcgact
     1621 gctgtgcaca cagatgccag atcctggaaa ttggctttct gctcttgaaa gtacgaagtg
     1681 gctccaccac ctgtctgtgc ttctgaagtc ggcacttctc gtggtgcatg ctgtggaccg
     1741 agatcagcga ccagtgctgg tgcactgctc agatggctgg gatcgcactc cccaaatcgt
     1801 ggccctggct aagcttctgc tggaccctta ttaccgaacc gtagagggtt tccaagtcct
     1861 tgtggagatg gaatggctgg attttggcca taagtttgct gatcggtgtg gtcatgggga
     1921 gaactcagat gacctgaatg agcgttgccc agtgtttctc caatggcttg actgtgttca
     1981 tcaactccag aggcaatttc cttgctcttt tgagttcaac gaagcattcc ttgtgaagct
     2041 ggttcagcac acctattcct gtctctttgg gacattcctg tgcaacaacg ccaaggagag
     2101 gggggagaag cagactcagg aacggacatg ctcggtgtgg tcgcttctgc gggccggcaa
     2161 caaggccttc aaaaacctgc tatattcatc ccagtcagaa gccgtgctgt accctgtgtg
     2221 ccatgtgcgg aatctgatgc tgtggagtgc agtgtacctt ccctgcccgt ccccatccac
     2281 ccccacagac gacagctgtg caccataccc agccccaggc accagccctg atgagcctcc
     2341 actgagccgg ctacccaaga ctagatcatt tgacaatctg accacaacct gtgacaacat
     2401 ggtgccgctg gccagccggc gcagcagtga ccccagcctg aatgagaagt ggcaggagca
     2461 cgggcgctcg ctggagttga gcagctttgc tggctctggg gaagaggtgc ctgccataga
     2521 cagcctgcgc aggcccagca ggctgctcgg aggagccgag ctatctgtgg cagctggtgt
     2581 ggctgaaggg cagatggaga atattttgca agaggccacc aaagaggaga gtggggtaga
     2641 agagcccacc cacagggagc acactgaggt gccagaggtc aaagaggagg cacccctagc
     2701 aaaagagagt aggacggcag ctcagggctc aggtgtactt taccaagaac cacagctgga
     2761 tgatgctact ctaaggagcc atttaggccc cagcctgtct tcgttctccc agggtattcc
     2821 tgagcatcgg gaggtggggc acagtgttct ctctagttca ctcccagctt ctctcagggg
     2881 agaggactcc caggaggtcc ctgtagaaca gcctcaagta gagaacattg cagaggacag
     2941 ggagaatgta gtccctgctg tcccagtaga tgtaaaaatt ggccttggta cctcagagtc
     3001 tagtcctctg ctgccttccc aagtcccatt cgagacaaga ggaccacaca tgaacaactc
     3061 cgtgcacatg ttattagaag ataaggtgaa gtccgagagt gggccccagc tccatcacag
     3121 accctgcctg gcaagcagtg gtagattcag tggcaaggac atgcttccta tagcaccaga
     3181 gcccaggtct gctgagaggc cccagtggga ctctgtgcta cacaggactt cttcccctgg
     3241 caacaccctc agcctgatga tgcaggctcc ttgtgccttg ccattagaca aatgtagaca
     3301 gagaattgtg tgcaacggtg ccctagagac tgaaaacaag gcctcagaac agcctgcagg
     3361 gtttgacacc cttcagaagt accccacacc caatgggcat tgtgccaatg gggagactgg
     3421 gaggagtaag gactcactga gccaccagct gtctgccaca agctatagct ctgctcactc
     3481 gtgctcaagg aacttgcacc acaagtggct gaatagccac tcggggaggc catccactac
     3541 caacagccct gagcagcctt cccgcagcca cctggatgat gacggcatgc ctgtgtacac
     3601 agacacgatc caacagcgcc tgcgacagat agagtctggt caccagcagg aagtggagac
     3661 cttgaagaaa caagtccagg aactgaagag tcgcctggag agccagtacc tgaccagctc
     3721 tctgcgcttc aatggggact ttggagatga agtgatgacc cgttggctac ctgaccactt
     3781 ggctgcccac tgctatgcct gtgacagtgc cttctggctt gccagtagga agcaccactg
     3841 cagggacact gaccgtgttg atcaaacgtg gaattgtggg aacgtattct gctccagttg
     3901 ttgtaaccag aaggttccag ttcccagcca gcagctcttt gaacccagtc gagtgtgcaa
     3961 gtcttgctat agcagcctcc atcccacaag ctccagcatt gaccttgaac tggataagcc
     4021 tattgctgcc acttcaaact gaagctcagt gacctggggt gacagaggcc atgctgctgt
     4081 ccctgtaaca ggctcacaca cagcctgggc agtccgagaa gcccatacat tttggatggg
     4141 ggcatggaac aacctgtaca gagattgggg tgtaccactg gatcgtagat cgattttcct
     4201 ttccttcccc ttccctttcc atcctcctct ttgccttcta aaaagaaaaa tgtcccagtt
     4261 gtcttaattt tttttaatgg aagcccagag gttaccaggc tcttagaact gctgagtggc
     4321 ttgctgtcgg gcactctgtg acatcactca gtgcttccct atggaaggag gcacaatgaa
     4381 ggcctgagac agcaggacag aaagccagcc taccattaat gaccgttctc cacatgaagc
     4441 tgtgccacag ttgactggtg cacctttgca gctggggagg ctggaagccc ttttcttgag
     4501 tactgttcct cagagggata gatagggcca tcctacctca cagacaaaaa gcaggatggt
     4561 gttgagagga agcacacagt gaagtgctcc acaggcctca ctttgaaaag agaggtatgt
     4621 gcttcttttg agttactgag ggcctagatg gctgacatgt tggcccaggt ggatccatct
     4681 ttaacaagat tgggtagggc tttctttgct tctttaggct tccagaccaa aaggtacaga
     4741 ctggccagaa agcagtatcc tgctgcagtg gtcaaggcct gcactgagct gggcacctga
     4801 ggtccccctc tgggtcctag tcccataagc aatctcttcc tcagccaaca cagggaaatc
     4861 cagactcagg gttccacagt ctcctgttcc caaagcaaac caatcatgca tctccccttg
     4921 agggacagat ccccacagtt ccgaagctct ccacacaatc agccttcctc tcttacttct
     4981 gggcagcagg aaggacccag gagtcccttg tcctgctttt ggctgcctga gtgggcacat
     5041 gtctggctct tgctatcagt gaagagccct tggtgattgt agggttctta gaagatgaca
     5101 tggctgagga gattcggggt accttcccgt agtgagcttt gatgtggtcc aaaaagagcc
     5161 ttaagtctgt agttatctgt gctggaggtg ggtatgaagg gtagagagca gttttggttt
     5221 gtactttgaa ttgttggcat ctgtctgtgc ccaccccatc ccccaagggt gatgcttggc
     5281 tctgccaaaa gctgcaatct ggtaacagag cagattatag tgttggggct gggtgaggct
     5341 gggtgaggct gggggacacc taattttagc ctggcctatg tccttgctcc tctcctctgg
     5401 aagctgttac ctggccatgg gccttccgtg tctcaggaag gtggcttctg catgttcctc
     5461 agtatgactg gagaagccag agccttccca gcagttgtgt gctgaaggga aggctgcagt
     5521 ctccgagtat tgctggtcct tcaggagcag gccgggcaga ggccgagttt agtgaaacag
     5581 ggtgaagttc tccaagctcg ctgtggtctg gagttgcggg tggggaaggt cggcataact
     5641 gaagactgca gttcctagtg agaggtgcca agaggttatg atacgggtgt cttgggtctg
     5701 ttgtacagtg tgaataagtg cttgcagctc ttagcccttt ttgatcaatg aagcactttt
     5761 ttattaatat tttctttgta tgtaaaggag gaaccgtaac tctccatagc tgtacatata
     5821 acccctttct cctaaagagg agtccgtgct cctatatttt tcattttttg tcaaagcaag
     5881 aagtaaatac tttagaattg ttaaatacat agataaagtg aataaagttg agtgtcagca
     5941 aggtg
//
LOCUS       NM_001436889            2614 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 16, mRNA.
ACCESSION   NM_001436889 XM_063275502
VERSION     NM_001436889.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275502.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55533.1,
                                           SRR26360194.1360841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-2614           JAXUCZ010000016.1  17573493-17573825
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2614
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2287
                     /gene="Eps15l1"
                     /note="isoform 16 is encoded by transcript variant 16;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 16"
                     /protein_id="NP_001423818.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKD"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1669
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2614
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 ggattgaact acagctgctg gttcgagcct ggagtctgcc cgcctagagg actggtctgc
     2341 agctgctgag ttgtatttgg tgtttgctgt gggactgaac tgctgcccaa gaagatcgag
     2401 ctcgcccccc acggactatt ggctggacag gttcacttcc cctatatcct aatggttttt
     2461 ctcttccatg acctctgctg ggtggtgggc tagaggagag gttgatatct tattaaaagt
     2521 aggttgaaaa tatgcctaca ggctgggggc atggctcaga ctctgagttc catctacagc
     2581 actgaataaa acagtaaaaa gattttaaaa ccaa
//
LOCUS       NM_001012105            2720 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 3, mRNA.
ACCESSION   NM_001012105 XM_233676
VERSION     NM_001012105.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2720)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001012105.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-412             JAXUCZ010000005.1  159052105-159052311
            413-601             JAXUCZ010000005.1  159052950-159053138
            602-763             JAXUCZ010000005.1  159053643-159053804
            764-886             JAXUCZ010000005.1  159054043-159054165
            887-1128            JAXUCZ010000005.1  159054558-159054799
            1129-1271           JAXUCZ010000005.1  159054883-159055025
            1272-1572           JAXUCZ010000005.1  159055113-159055413
            1573-1660           JAXUCZ010000005.1  159055678-159055765
            1661-1777           JAXUCZ010000005.1  159055850-159055966
            1778-1898           JAXUCZ010000005.1  159056048-159056168
            1899-2029           JAXUCZ010000005.1  159056301-159056431
            2030-2239           JAXUCZ010000005.1  159056701-159056910
            2240-2329           JAXUCZ010000005.1  159057023-159057112
            2330-2720           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2720
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            206..412
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2613
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform b is encoded by transcript variant 3; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform b"
                     /protein_id="NP_001012105.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEVCCVLSPGGDKRAKEEKAAATVLSRLDQA
                     RSSSSAGPGRELKEEWGGQAESASRGAEQTEKADAPREPPPVELKPDPTSSMAAAEAE
                     ALSESSEQEMEVEPASKGEEGQEEEGPGPATVKEEGVHLENGEPPEENEESAGTDSGH
                     ELGMEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSC
                     RECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGD
                     CGKLFTTSGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCD
                     KKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQ
                     FADPGALQRHVRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFV
                     QSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRV
                     DNLRSHVKTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVG
                     AAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQ
                     ALVMFQTDADFYQQYGPGGAWPAGQMLQAGELVFRPRDGTEGQPTLAETPPTAPDCLP
                     PAE"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1117..2112
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1117..2112
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1123..1185
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1123..1185
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1207..1269
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1207..1269
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1291..1353
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1291..1353
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1306..1308,1312..1314,1318..1320,1324..1329,
                     1336..1341,1348..1350,1390..1392,1396..1398,1408..1413,
                     1420..1425,1432..1434,1474..1476,1480..1482,1486..1488,
                     1492..1497,1504..1509,1516..1518)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1306..1308,1312..1314,1318..1320,1324..1329,
                     1336..1341,1348..1350,1390..1392,1396..1398,1408..1413,
                     1420..1425,1432..1434,1474..1476,1480..1482,1486..1488,
                     1492..1497,1504..1509,1516..1518)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1375..1437
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1375..1437
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1459..1521
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1459..1521
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1543..1605
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1543..1605
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1627..1689
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1627..1689
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1642..1644,1648..1650,1654..1656,1660..1665,
                     1672..1677,1684..1686,1726..1728,1732..1734,1744..1749,
                     1756..1761,1768..1770,1810..1812,1816..1818,1822..1824,
                     1828..1833,1840..1845,1852..1854)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1642..1644,1648..1650,1654..1656,1660..1665,
                     1672..1677,1684..1686,1726..1728,1732..1734,1744..1749,
                     1756..1761,1768..1770,1810..1812,1816..1818,1822..1824,
                     1828..1833,1840..1845,1852..1854)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1711..1773
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1711..1773
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1795..1857
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1795..1857
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1879..1941
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1879..1941
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1963..2025
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1963..2025
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2047..2106
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2047..2106
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            413..601
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            602..763
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            764..886
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1128
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1271
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1572
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1660
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1777
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1898
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2029
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2239
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2329
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2720
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagccatg gacttccccc agcacagcca gcgtgtcttg
      241 gagcagctga accagcagcg gcaaatgggc ctcctctgtg actgcacctt tgtggtggac
      301 ggcgttgact tcaaagctca caaggcggtg ctggcagcct gcagcgagta cttcaagatg
      361 ctctttgtgg accagaagga tgtggtgcac ctggacatca gtaatgcggc aggcctgggg
      421 caggtgctgg agttcatgta cactgctaaa ctgcacctta gccctgagaa cgtggatgat
      481 gttctggctg tggccagctt cctccagatg caggacatta tcacagcctg ccacaccctg
      541 aagtccctcg ctgagcccac cagcaccact ggggagagtg cagacgcctc ggccgaggaa
      601 gtctgttgtg ttctgtctcc aggaggagac aagcgagcca aagaagagaa ggctgccgcc
      661 accgtgctga gcaggctgga ccaagcaaga agcagttcat ccgcaggccc aggcagagag
      721 ctcaaagagg agtggggtgg tcaggcagag agtgcatcca ggggcgcaga acagacggag
      781 aaggccgacg cgccccggga gcctccacct gtggagctca agccggaccc cacgagcagc
      841 atggctgctg cagaagcgga agccttatca gagagctcag agcaagaaat ggaagtggaa
      901 ccagccagca aaggagaaga gggccaagag gaagagggcc cagggcctgc cacggtcaag
      961 gaagagggcg ttcacctgga gaacggggag cctcctgagg agaatgaaga gtctgcgggc
     1021 acagactctg ggcacgagct tggcatggag ggccagaacc tgcgctcggg cacctacggg
     1081 gaccgcactg agtccaaggc ttatggctcc atcatccaca agtgcgagga ctgcgggaag
     1141 gagttcacgc acacagggaa cttcaaacgg cacatccgca tccacacggg tgagaagcca
     1201 ttctcctgtc gggagtgcag caaggctttc tcggaccccg cagcctgcaa ggctcacgag
     1261 aagacacaca gcccgttgaa accctatggg tgcgaggagt gcggcaagag ctacaggctc
     1321 atcagcctgc tgaacctgca caagaagagg cactcggggg aggcgcgcta ccgctgcggg
     1381 gactgcggca agctcttcac cacttccggc aacctcaagc gccaccagct ggtacacagt
     1441 ggccagaaac cctaccagtg cgactactgt ggccgttcat tctccgaccc cacgtccaag
     1501 atgcgccacc tggagaccca tgacactgac aaggagcaca agtgccctca ctgtgacaag
     1561 aagttcaacc aggtggggaa cctgaaggcc cacttgaaga tccacattgc tgacggccct
     1621 ctcaagtgcc gggagtgcgg gaagcaattc accacctcag ggaacctcaa gcggcacctg
     1681 cggatccaca gcggggagaa gccgtatgta tgcacccact gtcagcggca gtttgctgac
     1741 ccaggcgcgc tgcagcggca cgtacggatc cacacgggtg agaagccgtg tcagtgcgtg
     1801 atatgtggca aggccttcac ccaagccagc tccctcatcg cccacgtacg ccagcacacg
     1861 ggggagaagc cctatgtctg tgaacgctgt ggcaagagat ttgtccagtc aagccagttg
     1921 gccaatcaca ttcgtcacca tgacaacatc cgcccacaca agtgcagcgt gtgtagcaag
     1981 gccttcgtga atgtggggga cctgtccaag cacattatca tccacactgg agagaagcct
     2041 tacttatgtg acaagtgtgg ccgtggtttc aaccgggtag acaacctgcg ttctcacgta
     2101 aagaccgtgc atcagggcaa ggcgggcatc aagatcctgg agccagaaga gggtggtgag
     2161 gtcagcgtgg tcactgtgga cgacatggtc acactggcca ctgaggcact ggcagcgaca
     2221 gcggtcactc agctcacagt ggtaccagtc ggggccgcag tgacagctga tgagacggag
     2281 gttctcaaag ctgagatcag caaagctgtc aagcaagtgc aggaagaaga tcccaacacc
     2341 cacatcctgt atgcgtgtga ttcctgtggg gacaagttcc tggatgccaa tagcctggcc
     2401 cagcacgttc ggatccacac agcacaggca ctggtcatgt tccagacgga tgcggacttc
     2461 taccagcagt acgggccagg tggcgcgtgg ccagccgggc agatgctgca ggctggagag
     2521 ctggtcttcc gtcctaggga tgggactgag ggccagccca cactggcaga aactccaccc
     2581 acagctcctg attgcctacc acctgccgag taagcaggtg gccctctgac tgtttattta
     2641 aggatgggtg gcaccccagg actcgaattc cggtgctcct gccccattcc ctagagagaa
     2701 taaatttgat tattttctaa
//
LOCUS       NM_001436886            2728 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 12, mRNA.
ACCESSION   NM_001436886 XM_008771122
VERSION     NM_001436886.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_008771122.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55529.1,
                                           SRR26643298.70777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1732           JAXUCZ010000016.1  17498298-17498369
            1733-1856           JAXUCZ010000016.1  17503674-17503797
            1857-1907           JAXUCZ010000016.1  17504488-17504538
            1908-2044           JAXUCZ010000016.1  17505392-17505528
            2045-2105           JAXUCZ010000016.1  17508313-17508373
            2106-2188           JAXUCZ010000016.1  17509056-17509138
            2189-2728           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2728
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2332
                     /gene="Eps15l1"
                     /note="isoform 12 is encoded by transcript variant 12;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 12"
                     /protein_id="NP_001423815.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     DDPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVT
                     DPFGGDPFKESDPFHSSTSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSS
                     SSISSKGSDPFGTLDPFGSSSFSSAEGFADFSQMSKFGNEEQQLAWAKRESEKAEQER
                     LARLRRQEQEDLELAIALSKADMPA"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1187..>1732
                     /gene="Eps15l1"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1732
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1907
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2044
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2105
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2188
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2728
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggatgatcc
     1741 tttcaaaaac aaagccttgt tgtttagcaa caactctcaa gagctgcatc cagacccctt
     1801 ccaggcagag gaccccttca agtctgaccc atttaaagga gctgatccct tcaaaggtga
     1861 ccctttccag agtgatccct tctcagagca gcagacagca gttacagacc catttggagg
     1921 ggaccctttc aaagaaagtg acccattcca tagctcaacc agtgatgact tcttcaagaa
     1981 acagacaaag aatgacccgt ttacctcaga ccccttcaca aagaaccctt ccttaccttc
     2041 aaagctcgac ccattcgagt ccagtgatcc cttctcatcc tccagcatct cctcgaaagg
     2101 ttcagatccc ttcggaacac tagacccctt tggaagcagc tccttcagca gtgccgaggg
     2161 tttcgctgac ttcagtcaga tgtccaagtt tggcaatgag gagcagcagc tggcctgggc
     2221 caaacgggag agtgagaaag cggagcagga gcggctggcg aggcttcggc gacaggaaca
     2281 ggaggacctg gagctggcca tcgccctcag caaggccgat atgccggcct aggtgacaca
     2341 ggggaagccg cagctgtctg tatgtccaca tcatgctcag agcgtgcccc cttcaagcca
     2401 agccatgcca cagccaagga cagctggcca cagggcctca ggccacaggg accttgttga
     2461 gaggtagcag acacagccca cgcctgtggg tgggccagga aggcagcctt cggtaaaagg
     2521 cctggaacct gcctgtctct gaggtgtcag tcaggctctt ccttccaatc attcagtgac
     2581 tgacggagaa ggcctccagt ctcctagcta cagacaagct ccaccccaac ccttcctcac
     2641 atccacaaga caccctgcac acatgatgta tgcattcgtt gtataaaaat gaagtttgaa
     2701 tgattaatat aaaatatttt aatacaaa
//
LOCUS       NM_001436931            5918 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3),
            transcript variant 5, mRNA.
ACCESSION   NM_001436931 XM_039092048
VERSION     NM_001436931.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5918)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 5918)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 5918)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 5918)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 5918)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 5918)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039092048.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47256.1,
                                           SRR26643287.30689.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  83684312-83684495   c
            185-320             JAXUCZ010000014.1  83674558-83674693   c
            321-369             JAXUCZ010000014.1  83628633-83628681   c
            370-454             JAXUCZ010000014.1  83627427-83627511   c
            455-532             JAXUCZ010000014.1  83614191-83614268   c
            533-622             JAXUCZ010000014.1  83611592-83611681   c
            623-739             JAXUCZ010000014.1  83611102-83611218   c
            740-822             JAXUCZ010000014.1  83604938-83605020   c
            823-989             JAXUCZ010000014.1  83602356-83602522   c
            990-1086            JAXUCZ010000014.1  83592224-83592320   c
            1087-1200           JAXUCZ010000014.1  83588725-83588838   c
            1201-1406           JAXUCZ010000014.1  83583226-83583431   c
            1407-1538           JAXUCZ010000014.1  83582300-83582431   c
            1539-1650           JAXUCZ010000014.1  83581721-83581832   c
            1651-1846           JAXUCZ010000014.1  83575932-83576127   c
            1847-2032           JAXUCZ010000014.1  83575039-83575224   c
            2033-2203           JAXUCZ010000014.1  83574230-83574400   c
            2204-2349           JAXUCZ010000014.1  83572847-83572992   c
            2350-3754           JAXUCZ010000014.1  83570317-83571721   c
            3755-3843           JAXUCZ010000014.1  83568438-83568526   c
            3844-5918           JAXUCZ010000014.1  83564065-83566139   c
FEATURES             Location/Qualifiers
     source          1..5918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5918
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..184
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..320
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..369
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..454
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..532
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    515..517
                     /gene="Mtmr3"
                     /note="upstream in-frame stop codon"
     CDS             530..4015
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="isoform 5 is encoded by transcript variant 5;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 5"
                     /protein_id="NP_001423860.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MDEEMRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEY
                     VGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFP
                     TFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRN
                     SCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWL
                     DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNM
                     VPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQE
                     PQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVE
                     NIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSE
                     SGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAP
                     CALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSH
                     QLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQR
                     LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVMTRWLPDHLAAHC
                     YACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSS
                     SIDLELDKPIAATSN"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    3761..3943
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    3761..3943
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    order(3764..3766,3773..3775,3827..3844,3848..3853,
                     3923..3931)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     misc_feature    order(3764..3766,3773..3775,3827..3844,3848..3853,
                     3923..3931)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     exon            533..622
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..739
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..989
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1086
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1200
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1406
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1538
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1650
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1846
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2032
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2203
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2349
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3754
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3843
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..5918
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccgc tgccgccatg ttgttgtggt tgtgagaagg cggcggcggc agcggtggcg
       61 gcggagcagc cggtggagac gctccagcgg cccaggcgct gccccccgcc gaccctggct
      121 ggcagcctcc tggggtggcg gaggaggccg tgcggtggcg ggcctcgcca tgtcctgcct
      181 cccgagtacc tggtgacctg ttttgactct ccatttggaa gggcctggtc tgtaccattg
      241 taaacatgct ttaccgagtt gtgatgactg ctcctcctcc ttgtttttgg cctgggaact
      301 gagcccaagg tcttatccag atttccttgt aaaaccttgt agaagaaaaa gttctcagga
      361 agatacttgt gcatcggagt cagaggctgg tgcaagctgg ctagccagag aaccaaatca
      421 gtgaaccccc agttctacag cagatcctgc cttagtctca agcagaagag aaagaagaac
      481 cttgtcagag actggagaag gacggggtct ctcctgacct ggtctggtca tggatgaaga
      541 gatgcggcat agccttgagt gcatccaggc caatcagatc tttcccagga agcagctgat
      601 tcgggaggat gaaaatcttc aggttccttt ccttgaactc catggagaga gcacagagta
      661 tgtgggccgt gctgaggatg ccatcattgc cctctctaat tacagacttc acatcaagtt
      721 taaggagtct cttgtgaatg ttccattaca gcttatagaa agcgttgaat gccgtgatat
      781 atttcagctt cacttgacat gcaaagactg caaagttatc aggtgtcagt tcccaacctt
      841 tgagcagtgt caagattggc ttaagagatt aaacaatgca atccgaccac ctggaaaaat
      901 agaagatctc ttctcatttg cataccatgc ttggtgcatg gaggtctatg ccagtgaaaa
      961 agagcagcat ggagacctgt gcagaccagg ggaacatgta acgtcaaggt ttaagaatga
     1021 agtggagcgg atgggttttg atatgaacaa tgcctggagg atttccaaca tcaatgagaa
     1081 atacaaatta tgtggtagtt atccacaaga gctcatagta cctgcctgga tcactgacaa
     1141 agaactagaa agcgtggcag gcttcagatc ctggaagcgc atccccgccg tcatctacag
     1201 gcaccagagc aatggagccg tcattgcccg ctgcggacag cccgaggtta gctggtgggg
     1261 ctggcggaat gctgatgatg aacatctggt gcagtcagtg gccaaggctt gtgcttctga
     1321 ctctcagtca agtgttggca aggtttccac tcggaacagt tgtcggggct ttcccaatgc
     1381 aggggatctt tctgatgtgg agttcgatgc ctctctgtca aatgcttcag gaacagaaag
     1441 tttagctctc cagccacaga agcttttgat cttggacgca cgctcctatg cagcagctgt
     1501 ggcaaatcga gccaaaggag ggggctgtga gtgtccagag tattatccaa actgtgaagt
     1561 tgtgtttatg ggaatggcaa acatacattc tatccggagg agtttccagt ctctgcgact
     1621 gctgtgcaca cagatgccag atcctggaaa ttggctttct gctcttgaaa gtacgaagtg
     1681 gctccaccac ctgtctgtgc ttctgaagtc ggcacttctc gtggtgcatg ctgtggaccg
     1741 agatcagcga ccagtgctgg tgcactgctc agatggctgg gatcgcactc cccaaatcgt
     1801 ggccctggct aagcttctgc tggaccctta ttaccgaacc gtagagggtt tccaagtcct
     1861 tgtggagatg gaatggctgg attttggcca taagtttgct gatcggtgtg gtcatgggga
     1921 gaactcagat gacctgaatg agcgttgccc agtgtttctc caatggcttg actgtgttca
     1981 tcaactccag aggcaatttc cttgctcttt tgagttcaac gaagcattcc ttgtgaagct
     2041 ggttcagcac acctattcct gtctctttgg gacattcctg tgcaacaacg ccaaggagag
     2101 gggggagaag cagactcagg aacggacatg ctcggtgtgg tcgcttctgc gggccggcaa
     2161 caaggccttc aaaaacctgc tatattcatc ccagtcagaa gccgtgctgt accctgtgtg
     2221 ccatgtgcgg aatctgatgc tgtggagtgc agtgtacctt ccctgcccgt ccccatccac
     2281 ccccacagac gacagctgtg caccataccc agccccaggc accagccctg atgagcctcc
     2341 actgagccgg ctacccaaga ctagatcatt tgacaatctg accacaacct gtgacaacat
     2401 ggtgccgctg gccagccggc gcagcagtga ccccagcctg aatgagaagt ggcaggagca
     2461 cgggcgctcg ctggagttga gcagctttgc tggctctggg gaagaggtgc ctgccataga
     2521 cagcctgcgc aggcccagca ggctgctcgg aggagccgag ctatctgtgg cagctggtgt
     2581 ggctgaaggg cagatggaga atattttgca agaggccacc aaagaggaga gtggggtaga
     2641 agagcccacc cacagggagc acactgaggt gccagaggtc aaagaggagg cacccctagc
     2701 aaaagagagt aggacggcag ctcagggctc aggtgtactt taccaagaac cacagctgga
     2761 tgatgctact ctaaggagcc atttaggccc cagcctgtct tcgttctccc agggtattcc
     2821 tgagcatcgg gaggtggggc acagtgttct ctctagttca ctcccagctt ctctcagggg
     2881 agaggactcc caggaggtcc ctgtagaaca gcctcaagta gagaacattg cagaggacag
     2941 ggagaatgta gtccctgctg tcccagtaga tgtaaaaatt ggccttggta cctcagagtc
     3001 tagtcctctg ctgccttccc aagtcccatt cgagacaaga ggaccacaca tgaacaactc
     3061 cgtgcacatg ttattagaag ataaggtgaa gtccgagagt gggccccagc tccatcacag
     3121 accctgcctg gcaagcagtg gtagattcag tggcaaggac atgcttccta tagcaccaga
     3181 gcccaggtct gctgagaggc cccagtggga ctctgtgcta cacaggactt cttcccctgg
     3241 caacaccctc agcctgatga tgcaggctcc ttgtgccttg ccattagaca aatgtagaca
     3301 gagaattgtg tgcaacggtg ccctagagac tgaaaacaag gcctcagaac agcctgcagg
     3361 gtttgacacc cttcagaagt accccacacc caatgggcat tgtgccaatg gggagactgg
     3421 gaggagtaag gactcactga gccaccagct gtctgccaca agctatagct ctgctcactc
     3481 gtgctcaagg aacttgcacc acaagtggct gaatagccac tcggggaggc catccactac
     3541 caacagccct gagcagcctt cccgcagcca cctggatgat gacggcatgc ctgtgtacac
     3601 agacacgatc caacagcgcc tgcgacagat agagtctggt caccagcagg aagtggagac
     3661 cttgaagaaa caagtccagg aactgaagag tcgcctggag agccagtacc tgaccagctc
     3721 tctgcgcttc aatggggact ttggagatga agtgatgacc cgttggctac ctgaccactt
     3781 ggctgcccac tgctatgcct gtgacagtgc cttctggctt gccagtagga agcaccactg
     3841 caggaattgt gggaacgtat tctgctccag ttgttgtaac cagaaggttc cagttcccag
     3901 ccagcagctc tttgaaccca gtcgagtgtg caagtcttgc tatagcagcc tccatcccac
     3961 aagctccagc attgaccttg aactggataa gcctattgct gccacttcaa actgaagctc
     4021 agtgacctgg ggtgacagag gccatgctgc tgtccctgta acaggctcac acacagcctg
     4081 ggcagtccga gaagcccata cattttggat gggggcatgg aacaacctgt acagagattg
     4141 gggtgtacca ctggatcgta gatcgatttt cctttccttc cccttccctt tccatcctcc
     4201 tctttgcctt ctaaaaagaa aaatgtccca gttgtcttaa ttttttttaa tggaagccca
     4261 gaggttacca ggctcttaga actgctgagt ggcttgctgt cgggcactct gtgacatcac
     4321 tcagtgcttc cctatggaag gaggcacaat gaaggcctga gacagcagga cagaaagcca
     4381 gcctaccatt aatgaccgtt ctccacatga agctgtgcca cagttgactg gtgcaccttt
     4441 gcagctgggg aggctggaag cccttttctt gagtactgtt cctcagaggg atagataggg
     4501 ccatcctacc tcacagacaa aaagcaggat ggtgttgaga ggaagcacac agtgaagtgc
     4561 tccacaggcc tcactttgaa aagagaggta tgtgcttctt ttgagttact gagggcctag
     4621 atggctgaca tgttggccca ggtggatcca tctttaacaa gattgggtag ggctttcttt
     4681 gcttctttag gcttccagac caaaaggtac agactggcca gaaagcagta tcctgctgca
     4741 gtggtcaagg cctgcactga gctgggcacc tgaggtcccc ctctgggtcc tagtcccata
     4801 agcaatctct tcctcagcca acacagggaa atccagactc agggttccac agtctcctgt
     4861 tcccaaagca aaccaatcat gcatctcccc ttgagggaca gatccccaca gttccgaagc
     4921 tctccacaca atcagccttc ctctcttact tctgggcagc aggaaggacc caggagtccc
     4981 ttgtcctgct tttggctgcc tgagtgggca catgtctggc tcttgctatc agtgaagagc
     5041 ccttggtgat tgtagggttc ttagaagatg acatggctga ggagattcgg ggtaccttcc
     5101 cgtagtgagc tttgatgtgg tccaaaaaga gccttaagtc tgtagttatc tgtgctggag
     5161 gtgggtatga agggtagaga gcagttttgg tttgtacttt gaattgttgg catctgtctg
     5221 tgcccacccc atcccccaag ggtgatgctt ggctctgcca aaagctgcaa tctggtaaca
     5281 gagcagatta tagtgttggg gctgggtgag gctgggtgag gctgggggac acctaatttt
     5341 agcctggcct atgtccttgc tcctctcctc tggaagctgt tacctggcca tgggccttcc
     5401 gtgtctcagg aaggtggctt ctgcatgttc ctcagtatga ctggagaagc cagagccttc
     5461 ccagcagttg tgtgctgaag ggaaggctgc agtctccgag tattgctggt ccttcaggag
     5521 caggccgggc agaggccgag tttagtgaaa cagggtgaag ttctccaagc tcgctgtggt
     5581 ctggagttgc gggtggggaa ggtcggcata actgaagact gcagttccta gtgagaggtg
     5641 ccaagaggtt atgatacggg tgtcttgggt ctgttgtaca gtgtgaataa gtgcttgcag
     5701 ctcttagccc tttttgatca atgaagcact tttttattaa tattttcttt gtatgtaaag
     5761 gaggaaccgt aactctccat agctgtacat ataacccctt tctcctaaag aggagtccgt
     5821 gctcctatat ttttcatttt ttgtcaaagc aagaagtaaa tactttagaa ttgttaaata
     5881 catagataaa gtgaataaag ttgagtgtca gcaaggtg
//
LOCUS       NM_001436940             822 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 8, mRNA.
ACCESSION   NM_001436940 XM_017593471
VERSION     NM_001436940.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 822)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 822)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 822)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 822)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 822)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017593471.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2349994.1,
                                           SRR26360181.87742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000005.1  61744292-61744375   c
            85-211              JAXUCZ010000005.1  61743399-61743525   c
            212-250             JAXUCZ010000005.1  61743164-61743202   c
            251-318             JAXUCZ010000005.1  61741422-61741489   c
            319-378             JAXUCZ010000005.1  61741152-61741211   c
            379-822             JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..822
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..84
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            85..211
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    143..145
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             209..535
                     /gene="Ccl27"
                     /note="isoform e is encoded by transcript variant 8; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform e"
                     /protein_id="NP_001423869.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MEEWSSEDGCAGPAEPFGARDMSRLRRYEVALEAEEEIYWGCFY
                     FFPWLRMWRRERSSAHPREQKLEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQT
                     AGALKI"
     exon            212..250
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            251..318
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            319..378
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            379..822
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaatagag gagaaagaaa agtggccagc acgaacagaa acagccctca agaaatctac
       61 ttcatagagc tgtcatgaga caagtagact cagacaagtt gcatcctgga cctgcttccc
      121 atgtctctca tccctacttc cctaaattct ctgtgaactg accaacatct ctcctcaaaa
      181 acccctcaac cctcaagaaa gggagagcat ggaggagtgg agttcagagg atggctgcgc
      241 aggccctgca gaaccgttcg gagctcgaga catgtcgcga ttgaggagat acgaggtggc
      301 gctggaagcg gaggaggaga tctactgggg ctgcttctac ttttttcctt ggctgcgaat
      361 gtggcgcagg gagcggagct cggcgcaccc ccgggagcag aagctggagc ctctgcgggg
      421 cctaatgagc tgtttgtcga gcggcctgag gcctgctccc cagcgctcag gtcgcggtct
      481 cctctgtcgc acccccaccg ctgctgcaca gacagccggt gcattaaaga tttaaagtca
      541 cgcccactgc cttcctgact ttaccgccgc agccgccact ggtgctggga atcccactcc
      601 acacctgctg tttcttagcc cacagggcat ccctccctgg taggaagccc ttgcatgtct
      661 aagcctccaa tgtccctaaa ggtcaagctg ccaattacta tcagtgactg gctccctgcc
      721 acgccctccc caaaagcacc cacactgaga gtgtaggcca catctgtcca ccacttccca
      781 gtattcccac aacttcagct attaccatct tcctctagcc gt
//
LOCUS       NM_001436863            2995 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 2, mRNA.
ACCESSION   NM_001436863 XM_063287815
VERSION     NM_001436863.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2995)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2995)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2995)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287815.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-329             JAXUCZ010000005.1  159039733-159039856
            330-426             JAXUCZ010000005.1  159042847-159042943
            427-633             JAXUCZ010000005.1  159052105-159052311
            634-822             JAXUCZ010000005.1  159052950-159053138
            823-963             JAXUCZ010000005.1  159053664-159053804
            964-1161            JAXUCZ010000005.1  159053968-159054165
            1162-1403           JAXUCZ010000005.1  159054558-159054799
            1404-1546           JAXUCZ010000005.1  159054883-159055025
            1547-1847           JAXUCZ010000005.1  159055113-159055413
            1848-1935           JAXUCZ010000005.1  159055678-159055765
            1936-2052           JAXUCZ010000005.1  159055850-159055966
            2053-2173           JAXUCZ010000005.1  159056048-159056168
            2174-2304           JAXUCZ010000005.1  159056301-159056431
            2305-2514           JAXUCZ010000005.1  159056701-159056910
            2515-2604           JAXUCZ010000005.1  159057023-159057112
            2605-2995           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2995
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2995
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            206..329
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            330..426
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    384..386
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            427..633
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..2888
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform a"
                     /protein_id="NP_001423792.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEGGDKRAKEEKAAATVLSRLDQARSSSSAG
                     PGRELKEEWGGQAESASRGFVPAMEETHLTSAQSPNPASHPSSGAEQTEKADAPREPP
                     PVELKPDPTSSMAAAEAEALSESSEQEMEVEPASKGEEGQEEEGPGPATVKEEGVHLE
                     NGEPPEENEESAGTDSGHELGMEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHT
                     GNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISL
                     LNLHKKRHSGEARYRCGDCGKLFTTSGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKM
                     RHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRH
                     LRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTGEKPCQCVICGKAFTQASSLIAHVR
                     QHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIH
                     TGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLA
                     TEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGD
                     KFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGAWPAGQMLQAGELVFRPRDGT
                     EGQPTLAETPPTAPDCLPPAE"
     misc_feature    432..767
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    432..767
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(435..440,444..461,465..470,477..479,492..497,
                     540..542,546..548,555..563,576..578,654..659,666..677,
                     735..737)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(435..440,444..461,465..470,477..479,492..497,
                     540..542,546..548,555..563,576..578,654..659,666..677,
                     735..737)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(489..491,498..524,528..530,534..536,543..545,
                     603..608,612..617,621..623)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(489..491,498..524,528..530,534..536,543..545,
                     603..608,612..617,621..623)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1392..2387
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1392..2387
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1398..1460
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1398..1460
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1482..1544
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1482..1544
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1566..1628
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1566..1628
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1581..1583,1587..1589,1593..1595,1599..1604,
                     1611..1616,1623..1625,1665..1667,1671..1673,1683..1688,
                     1695..1700,1707..1709,1749..1751,1755..1757,1761..1763,
                     1767..1772,1779..1784,1791..1793)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1581..1583,1587..1589,1593..1595,1599..1604,
                     1611..1616,1623..1625,1665..1667,1671..1673,1683..1688,
                     1695..1700,1707..1709,1749..1751,1755..1757,1761..1763,
                     1767..1772,1779..1784,1791..1793)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1650..1712
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1650..1712
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1734..1796
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1734..1796
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1818..1880
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1818..1880
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1902..1964
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1902..1964
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1917..1919,1923..1925,1929..1931,1935..1940,
                     1947..1952,1959..1961,2001..2003,2007..2009,2019..2024,
                     2031..2036,2043..2045,2085..2087,2091..2093,2097..2099,
                     2103..2108,2115..2120,2127..2129)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1917..1919,1923..1925,1929..1931,1935..1940,
                     1947..1952,1959..1961,2001..2003,2007..2009,2019..2024,
                     2031..2036,2043..2045,2085..2087,2091..2093,2097..2099,
                     2103..2108,2115..2120,2127..2129)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1986..2048
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1986..2048
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2070..2132
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2070..2132
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2154..2216
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2154..2216
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2238..2300
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2238..2300
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2322..2381
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2322..2381
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            634..822
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            823..963
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1161
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1403
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1847
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1935
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2052
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2173
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2304
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2514
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2604
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2995
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagtgtct ctacccatgg ctgtctagtc cttcccggct
      241 tcacaatcac agaggtctgt tggtgcttcc caggggctgg gattaaaggc atacgtcacc
      301 acactcggct tttatcttat tttaattaga ttctatcctc ggagccatct ctccaactgg
      361 aaaagaaagc ctcagtttcc atgtaacttc tcagtccttt ctttggtgct cgcactttct
      421 gcttagccat ggacttcccc cagcacagcc agcgtgtctt ggagcagctg aaccagcagc
      481 ggcaaatggg cctcctctgt gactgcacct ttgtggtgga cggcgttgac ttcaaagctc
      541 acaaggcggt gctggcagcc tgcagcgagt acttcaagat gctctttgtg gaccagaagg
      601 atgtggtgca cctggacatc agtaatgcgg caggcctggg gcaggtgctg gagttcatgt
      661 acactgctaa actgcacctt agccctgaga acgtggatga tgttctggct gtggccagct
      721 tcctccagat gcaggacatt atcacagcct gccacaccct gaagtccctc gctgagccca
      781 ccagcaccac tggggagagt gcagacgcct cggccgagga aggaggagac aagcgagcca
      841 aagaagagaa ggctgccgcc accgtgctga gcaggctgga ccaagcaaga agcagttcat
      901 ccgcaggccc aggcagagag ctcaaagagg agtggggtgg tcaggcagag agtgcatcca
      961 gggggtttgt tccagccatg gaagagaccc atttgacctc tgcacagagt cccaatccag
     1021 cctcccatcc ctcctcaggc gcagaacaga cggagaaggc cgacgcgccc cgggagcctc
     1081 cacctgtgga gctcaagccg gaccccacga gcagcatggc tgctgcagaa gcggaagcct
     1141 tatcagagag ctcagagcaa gaaatggaag tggaaccagc cagcaaagga gaagagggcc
     1201 aagaggaaga gggcccaggg cctgccacgg tcaaggaaga gggcgttcac ctggagaacg
     1261 gggagcctcc tgaggagaat gaagagtctg cgggcacaga ctctgggcac gagcttggca
     1321 tggagggcca gaacctgcgc tcgggcacct acggggaccg cactgagtcc aaggcttatg
     1381 gctccatcat ccacaagtgc gaggactgcg ggaaggagtt cacgcacaca gggaacttca
     1441 aacggcacat ccgcatccac acgggtgaga agccattctc ctgtcgggag tgcagcaagg
     1501 ctttctcgga ccccgcagcc tgcaaggctc acgagaagac acacagcccg ttgaaaccct
     1561 atgggtgcga ggagtgcggc aagagctaca ggctcatcag cctgctgaac ctgcacaaga
     1621 agaggcactc gggggaggcg cgctaccgct gcggggactg cggcaagctc ttcaccactt
     1681 ccggcaacct caagcgccac cagctggtac acagtggcca gaaaccctac cagtgcgact
     1741 actgtggccg ttcattctcc gaccccacgt ccaagatgcg ccacctggag acccatgaca
     1801 ctgacaagga gcacaagtgc cctcactgtg acaagaagtt caaccaggtg gggaacctga
     1861 aggcccactt gaagatccac attgctgacg gccctctcaa gtgccgggag tgcgggaagc
     1921 aattcaccac ctcagggaac ctcaagcggc acctgcggat ccacagcggg gagaagccgt
     1981 atgtatgcac ccactgtcag cggcagtttg ctgacccagg cgcgctgcag cggcacgtac
     2041 ggatccacac gggtgagaag ccgtgtcagt gcgtgatatg tggcaaggcc ttcacccaag
     2101 ccagctccct catcgcccac gtacgccagc acacggggga gaagccctat gtctgtgaac
     2161 gctgtggcaa gagatttgtc cagtcaagcc agttggccaa tcacattcgt caccatgaca
     2221 acatccgccc acacaagtgc agcgtgtgta gcaaggcctt cgtgaatgtg ggggacctgt
     2281 ccaagcacat tatcatccac actggagaga agccttactt atgtgacaag tgtggccgtg
     2341 gtttcaaccg ggtagacaac ctgcgttctc acgtaaagac cgtgcatcag ggcaaggcgg
     2401 gcatcaagat cctggagcca gaagagggtg gtgaggtcag cgtggtcact gtggacgaca
     2461 tggtcacact ggccactgag gcactggcag cgacagcggt cactcagctc acagtggtac
     2521 cagtcggggc cgcagtgaca gctgatgaga cggaggttct caaagctgag atcagcaaag
     2581 ctgtcaagca agtgcaggaa gaagatccca acacccacat cctgtatgcg tgtgattcct
     2641 gtggggacaa gttcctggat gccaatagcc tggcccagca cgttcggatc cacacagcac
     2701 aggcactggt catgttccag acggatgcgg acttctacca gcagtacggg ccaggtggcg
     2761 cgtggccagc cgggcagatg ctgcaggctg gagagctggt cttccgtcct agggatggga
     2821 ctgagggcca gcccacactg gcagaaactc cacccacagc tcctgattgc ctaccacctg
     2881 ccgagtaagc aggtggccct ctgactgttt atttaaggat gggtggcacc ccaggactcg
     2941 aattccggtg ctcctgcccc attccctaga gagaataaat ttgattattt tctaa
//
LOCUS       NM_001436949            4336 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript
            variant 3, mRNA.
ACCESSION   NM_001436949 XM_008770315
VERSION     NM_001436949.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4336)
  AUTHORS   Young,G.P., Symonds,E.L., Nielsen,H.J., Ferm,L., Christensen,I.J.,
            Dekker,E., van der Vlugt,M., Mallant-Hent,R.C., Boulter,N., Yu,B.,
            Chan,M., Tevz,G., LaPointe,L.C. and Pedersen,S.K.
  TITLE     Evaluation of a panel of tumor-specific differentially-methylated
            DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of
            colorectal cancer
  JOURNAL   Clin Epigenetics 13 (1), 14 (2021)
   PUBMED   33478584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4336)
  AUTHORS   Sharma,B., Shah,R., Jamwal,R.S., Verma,S., Bhat,A., Bhat,G.R.,
            Bakshi,D., Singh,S., Angurana,S., Bhat,A., Vaishnavi,S. and
            Kumar,R.
  TITLE     Evaluation of newly identified Ikaros family zinc finger 1 loci in
            colorectal cancer
  JOURNAL   J Cancer Res Ther 17 (1), 46-50 (2021)
   PUBMED   33723131
REFERENCE   3  (bases 1 to 4336)
  AUTHORS   Musher,B.L., Melson,J.E., Amato,G., Chan,D., Hill,M., Khan,I.,
            Kochuparambil,S.T., Lyons,S.E., Orsini,J. Jr., Pedersen,S.K.,
            Robb,B., Saltzman,J., Silinsky,J., Gaur,S., Tuck,M.K.,
            LaPointe,L.C. and Young,G.P.
  TITLE     Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1
            to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC)
  JOURNAL   Cancer Epidemiol Biomarkers Prev 29 (12), 2702-2709 (2020)
   PUBMED   32958500
REFERENCE   4  (bases 1 to 4336)
  AUTHORS   Zhao,W., Chen,T.B. and Wang,H.
  TITLE     Ikaros is heterogeneously expressed in lung adenocarcinoma and is
            involved in its progression
  JOURNAL   J Int Med Res 48 (8), 300060520945860 (2020)
   PUBMED   32787735
REFERENCE   5  (bases 1 to 4336)
  AUTHORS   Symonds,E.L., Pedersen,S.K., Murray,D., Byrne,S.E., Roy,A.,
            Karapetis,C., Hollington,P., Rabbitt,P., Jones,F.S., LaPointe,L.,
            Segelov,E. and Young,G.P.
  TITLE     Circulating epigenetic biomarkers for detection of recurrent
            colorectal cancer
  JOURNAL   Cancer 126 (7), 1460-1469 (2020)
   PUBMED   31909823
REFERENCE   6  (bases 1 to 4336)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
REFERENCE   7  (bases 1 to 4336)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   8  (bases 1 to 4336)
  AUTHORS   Boggs,S.S., Trevisan,M., Patrene,K. and Geogopoulos,K.
  TITLE     Lack of natural killer cell precursors in fetal liver of Ikaros
            knockout mutant mice
  JOURNAL   Nat Immun 16 (4), 137-145 (1998)
   PUBMED   10366784
REFERENCE   9  (bases 1 to 4336)
  AUTHORS   Molnar,A. and Georgopoulos,K.
  TITLE     The Ikaros gene encodes a family of functionally diverse zinc
            finger DNA-binding proteins
  JOURNAL   Mol Cell Biol 14 (12), 8292-8303 (1994)
   PUBMED   7969165
REFERENCE   10 (bases 1 to 4336)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_008770315.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.17390.1,
                                           SRR26643292.52730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000014.1  90469387-90469437
            52-105              JAXUCZ010000014.1  90483799-90483852
            106-222             JAXUCZ010000014.1  90491020-90491136
            223-390             JAXUCZ010000014.1  90537327-90537494
            391-513             JAXUCZ010000014.1  90541436-90541558
            514-648             JAXUCZ010000014.1  90544514-90544648
            649-4336            JAXUCZ010000014.1  90552834-90556521
FEATURES             Location/Qualifiers
     source          1..4336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4336
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
     exon            1..51
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            52..105
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1352
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="isoform 1 is encoded by transcript variant 3;
                     DNA-binding protein Ikaros"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros isoform 1"
                     /protein_id="NP_001423878.1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
                     /translation="MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQ
                     NSKSDRGMGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTG
                     HLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGMYPVIKEETNHSEM
                     AEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSANYEKDEMMTSH
                     VMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQD
                     SAVENLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHITPHARNG
                     LALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGC
                     HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS"
     misc_feature    <66..>455
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <66..>455
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    234..302
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    234..302
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    240..302
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    240..302
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(255..257,261..263,267..269,273..278,285..290,
                     297..299,339..341,345..347,357..362,369..374,381..383,
                     423..425,429..431,435..437,441..446,453..458,468..470)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(255..257,261..263,267..269,273..278,285..290,
                     297..299,339..341,345..347,357..362,369..374,381..383,
                     423..425,429..431,435..437,441..446,453..458,468..470)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    276..353
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    276..353
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    324..386
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    324..386
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    408..473
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    408..473
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            106..222
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            223..390
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            391..513
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            514..648
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            649..4336
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggccc ggcgcgggca agcgggctgc agccgccggc ggcgccagca gataatctga
       61 agacaatgga tgtcgatgag ggtcaagaca tgtcccaagt ttcaggaaag gagagccctc
      121 cagtcagtga cactccggat gaaggggatg aacccatgcc tgtccccgag gacctgtcca
      181 cctctggagc acagcagaac tccaagagtg atcgaggcat gggtgaacgg cctttccagt
      241 gcaaccagtg tggggcctcc tttacccaga aaggcaacct actgcggcac atcaagctgc
      301 actcgggcga gaagcccttc aaatgccatc tctgcaacta tgcctgccgc cggagggacg
      361 ccctcaccgg ccacctaagg acgcactccg ttggtaagcc tcacaaatgt ggatattgtg
      421 gccggagcta taaacagcga agctctttag aagaacataa agagcgatgc cacaactact
      481 tggaaagcat gggcctcccg ggcatgtacc cagtcattaa ggaagaaact aaccacagcg
      541 aaatggcaga ggacctgtgc aagataggag cagagaggtc ccttgttctg gacaggctgg
      601 ccagcaacgt cgccaaacgt aagagctcta tgcctcagaa atttcttgga gacaagtgcc
      661 tgtcagacat gccctatgac agtgccaact atgagaagga tgagatgatg acatcccacg
      721 tgatggacca ggccatcaac aatgccatta actacctggg ggctgagtcc ctgcgcccgt
      781 tggtgcagac accccctggt agctccgagg tggtgccggt catcagttcc atgtaccagc
      841 tgcacaagcc cccctcagac ggcccaccac ggtccaacca ctcagcacag gacagcgccg
      901 tggagaactt gctgctgctg tccaaggcca agtccgtgtc atcagagcgg gaggcctccc
      961 caagcaacag ctgccaagac tccacggata cagagagcaa cgcggaggaa cagcgcagcg
     1021 gtctcatcta cctaaccaac cacatcactc cgcatgcgcg caacgggctg gctctcaagg
     1081 aggagcagcg cgcctacgag gtgctgaggg cagcctcaga gaactcgcag gacgccttcc
     1141 gtgtggtcag cacgagtggt gagcagctga aggtgtacaa gtgcgaacac tgccgcgtgc
     1201 tcttcctgga tcatgtcatg tacaccatcc acatgggctg ccatggcttc cgggatccct
     1261 ttgagtgtaa catgtgtggt tatcacagcc aggacaggta cgagttctct tcccacatca
     1321 cacgggggga gcatcgctac cacctgagct aaacccagcc aggccccact gaagcacaaa
     1381 gatagctggg catgcctctt tcccagcagc tggacccacg gcggacaatg ttgggagtgg
     1441 atttgcaggc agcatttgtt cttttacgtt ggttgtttga gatttgattt gcgtttagaa
     1501 gacaagtttt taatgttaga gacaggattc cattgcatca ggaacgttca gaacacccat
     1561 ccttctagac ggttttgttg actgctagct gagatttccc tggtatgtgg cttcctaacg
     1621 ctctccctac ccgccccacc cccaaaacag agcccgaatc ttcagagaaa ttaattaaac
     1681 aattacccaa gtaggagcaa ggtggatttt tccctaagca gagtttatac cacaaagatt
     1741 ctccaagtcc tccaaaacag cacagggaca tcagcctgtg cagagaccag ggccgaaggc
     1801 tgaacttaga aagctactat taggccatgt attgcacggc aatgcggtgt cggaacaaga
     1861 tgtttgaggt gctgaaggga agggattgga gagccatgtg gctcttcttc atttgcctga
     1921 tcacactcag cctcctgagg gcttgatgcc cagtaagatg agctcactgc tcttgtgatc
     1981 gtttttctat cagttccgtg cctttaatgg ccccaaagct catcactgca ttttagaacc
     2041 caatcctgaa attgagacct tgttttaaac ttctgatact gtaaaacttc ttggaagcca
     2101 aagctttctt ccaagcccca tccccagtta tcttggttcc tgttcttccc tgggctgata
     2161 gttccgggac ctgctattcc atgaaaacaa gcacaaccca cccttcactt caactgaacc
     2221 cctgttctga ttatagctat ggactcggct gtcttgataa atgtctttcc ctgctctgga
     2281 tgtatgttat tttctttgaa aacctgtgac accattatcc agaatgacca tttttagatg
     2341 gaagaaatat gtgagcccag catctcagtg gctaaaacac aaaatatcca tactttcaaa
     2401 caaaattttt aaatattcca aagctctctt ctatagacac ccagtagcac atgttttcac
     2461 ataaatagga tacgggacca tgcaaccttt atcaagtaga ggtattagaa tggtgtgagg
     2521 tttggaggca gagtgtgacc agtacaggtt cccagagaac ctgtatagcc agaccaagac
     2581 agagatgtca cgctgaagac aagtcaatta gctagaggtt ctcagcagaa aggcctctct
     2641 caagagtcag tattagggtt gctaccctct atcagctcaa cagaaataat tgtaaatgtt
     2701 tacagcactg tcttcacaga aacttgttgc tgtaaaatta taaaaaatgc tgtcttctcc
     2761 cctgcactag gtcaagcact gcagcgcccc aagatagctg gtagatactt catctcagtc
     2821 agcaaagcgt ctcacccgct cttctccatc ccatatcaca cagacaatgg ctactctctg
     2881 agcctggcaa caatctctct gcccatctag ttgtcaaggc aggttgccac catgccagac
     2941 atacacatcc caattccatg gtggcccagt gtctccacca ccacaaactc tctttaactt
     3001 aaatcgccct atgaaagaac acacaacaca atgacctctg atccaattga tgagatataa
     3061 tttgctcatc tagacacaaa aaaccctgta cacatccacc ccttaagaat attcataaca
     3121 acctgtaaat gtgcagagag gaatcttaac atccgcctcc atgttctctc ctctgcttct
     3181 cctgcctcct ccagtctcct cctctctcta aaatatttct cctgcccatc cttccttctc
     3241 atccaatgac aggcctcctt ctctcttgta cctgccttca cctgaatgac atcctacaga
     3301 aactttctga ggtgattcca cagaactgga ggagagattg tctataacag cttttgagct
     3361 aaaatgacgt tcttagtcgc agctctcctg acatacaggg catgatcatc actggtgggg
     3421 gtcgttctgt gaaatgcagc ttgcttagta ctacccctgg tcactcccca ctagatgcca
     3481 ggagcaccct agctgatacc caaaactgtc ttcccgggtg ctccatgggc ggaaaactac
     3541 tgatctaaac tctaaatgag tgcaaagtac ggaagttttc caaaaagtaa aaagcacttg
     3601 aagcctttcc cggtcagcag cctcaagctg tactgtgtct ttgcagtgct gatgaattct
     3661 ataaatcagc attggcaaat acacttcaga tacttctgag ttcaagtgaa gggacagagt
     3721 tcacaaaggt atccctctta agtctgtgtt tctttgtttc cagaacaaca tggcatttcg
     3781 aaagcgaaag taaaattaca aatataacga cgtacagtga ataaagggag agaatttgag
     3841 gaactagagc tgtggacagt ttttgttcca tatgcaatta taggactggc cttacccaaa
     3901 ttcacatatt ccaggtgaca accttccaag cctacaattt gctggcagct tttactcact
     3961 cttgttctta gcaatgagag ccattaagta tggtccaagg aagatggctc caaaccccac
     4021 cgccaccccc gcccccaccc ctgacactgg taatcaaagg ttaaagcgga attgtaaata
     4081 gtggcttcag gagctgtttt ttagaatgct ttgccctttc ctctcactgc cttttttagc
     4141 caatataaat gtctatttgc acaccttttg ttgtggtttt atattgtaac agcatttttt
     4201 tgaaactatt gtatttaaga taaggtttca tattatgccc acaagtaatt aaattatgtt
     4261 tgaaggtggc tatattctgt atcaaaagtt gataatgttt ttctttagct ggtaaagtag
     4321 ggttttgcat gagctc
//
LOCUS       NM_001436854            3056 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 4, mRNA.
ACCESSION   NM_001436854 XM_039110063
VERSION     NM_001436854.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3056)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110063.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217687.1, SRR26643288.24451.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000005.1  155719134-155719237
            105-204             JAXUCZ010000005.1  155724942-155725041
            205-358             JAXUCZ010000005.1  155726205-155726358
            359-518             JAXUCZ010000005.1  155728962-155729121
            519-662             JAXUCZ010000005.1  155732660-155732803
            663-740             JAXUCZ010000005.1  155734814-155734891
            741-892             JAXUCZ010000005.1  155735359-155735510
            893-983             JAXUCZ010000005.1  155738870-155738960
            984-1143            JAXUCZ010000005.1  155740995-155741154
            1144-1255           JAXUCZ010000005.1  155742543-155742654
            1256-1372           JAXUCZ010000005.1  155743955-155744071
            1373-3056           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3056
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..104
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..204
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1670
                     /gene="Hp1bp3"
                     /note="isoform b is encoded by transcript variant 4"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform b"
                     /protein_id="NP_001423783.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPE
                     NETPPAPSREAEQPKGEPESGEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLS
                     ASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLER
                     RGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVK
                     LEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQ
                     ITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPG
                     TNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSE
                     DEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRG
                     KVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKK
                     KSFKTKK"
     misc_feature    471..725
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    471..725
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(492..494,528..530,624..626,666..668)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(492..494,528..530,624..626,666..668)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    609..644
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    609..644
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    798..980
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    798..980
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1026..1229
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1026..1229
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1413..>1637
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1413..>1637
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            205..358
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..518
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            519..662
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..740
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..892
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..983
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1143
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1255
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1372
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..3056
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcggt gcccggcctg gaggacagcg gtgtcggagt cagcgatcgg tggtccgcag
       61 caacgctgag gggccgtacg ggacgcaggc gccggagctc agagaaagca gacgatagca
      121 ccatgcctat ccgtcgggct gtgaattcta ctcgggaaac tccgcccaaa agcaaacttg
      181 ctgaagggga agaagaaaaa ccagaaccag atgggagttc agaggagtct atctctacgg
      241 tagaagaacc agagaatgag actccacctg ctccatccag ggaggcagag cagcccaagg
      301 gggagcctga gagtggagag aaggaagaga gcaagtctgc tgaggaaacc aagaaagaag
      361 agaaggatca gtctaaagaa aaggagaaga aagtgaagaa aaccatccct gcctgggcca
      421 ctctgtctgc cagccagcta gccagggccc agaaacaaac cccaatggct tcctccccac
      481 ggccaaagat ggatgcaatc ttaactgagg ccattaaggc atgcttccag aagagcggtg
      541 cctccgtggt tgctatccgg aagtacatca ttcataagta cccttctctg gatctggaga
      601 gaaggggcta tctcctcaag caagcactga aaagagagtt aaacagagga gtcatcaaac
      661 aggtaaaagg aaaaggtgca tctggcagtt ttgtcgtggt ccagaaatca aaaacacctc
      721 agaaatccaa aaacagaaag aagggctctg cagtggatcc agaaccacaa gtaaaactgg
      781 aagatgttct cccattggct tttacccgac tctgtgaacc taaggaagcc tcctacagtc
      841 tcatcaggaa atacgtgtct cagtattacc ctaagcttcg agtggacatc aggccccagt
      901 tgttgaagaa tgctctgcag agagcagtgg agagaggcca gttagagcag ataactggca
      961 agggtgcttc ggggacattc cagctgaaga aatccgggga gaaacccctg cttggtggaa
     1021 gcctgatgga atatgcaatc ttgtctgcca ttgctgccat gaatgaacct aagacctgct
     1081 ccaccactgc tctgaagaag tatgtcctgg agaaccaccc agggaccaat tctaactacc
     1141 aaatgcattt gctgaaaaaa actctgcaga aatgtgagaa gaatgggtgg ctggagcaga
     1201 tctctgggaa ggggttcagc ggcaccttcc agctgtgctt cccctattac cccagcccag
     1261 gagttctgtt tccaaagaaa gtgtcagatg gctctgagga tgaggatgag gaggaggatg
     1321 aagaggagtc atcagaggac tctgaggatg aagagccgcc acccaagagg agcttacaga
     1381 agaaaacacc agccaagccc caagggaaga cggcctccat gaagcagaga ggggctaagc
     1441 ctgcgcgtaa agtccctgct gcccagagag ggaaggtgag gccgctgcct aagaaagctc
     1501 cgcccaaggc taagacccct gccaggaaag gcagacccgc accctcagcc gtcaagaagc
     1561 ctagcgggag cacctccaaa aagcctgtag ccaatgcacg aaaggaagcg aaactgcccg
     1621 gtaagggcaa atctgccatg aagaagaagt ctttcaagac aaaaaagtaa attttatagg
     1681 aaaaagggta tcatgattga attcagaatc ttattttata aggtcagtgt gcatttgttt
     1741 tagttataat gcttttaaat tttacatttt tcttcccata cgaacactgt gggaaggaat
     1801 gtaaacaaac cagtgtagac atttgttggc ttaggtgctg ttctcagtgc ctgcttcttc
     1861 atcattttaa tttctgccgt aatcctggac ttggctgaac tgtgtaacta ccctgctccc
     1921 tttgttcatc ttaacccaac cctcattctc ttctttttgt gatccaattt ggggttttct
     1981 tttcctcctc gaagttaatc caaacagttg caaagatgca tttgtagtga gtacctccag
     2041 gtctggtgct gaagccagac ggagcgggag cactacaggg acagcattgc ttcctgcctg
     2101 gggacttgct gattgaccct ggctgtgaaa tcactccact aacctttctc cagcgtgggc
     2161 cagggacatt ataactttgg aaagaagccc cagtctgcca tccatagatt ctgaagatct
     2221 cttctccttt gctgtctgcc cagttgccaa gcacgccctg ctgcccagag cgttgttccc
     2281 ttaacagcaa gcgcacgtct gcgccacctg ctttctgact gaaggggaag tacaggaata
     2341 tgtggaatct gattgcttat taccaaaaat gacagaatat tcttgatcaa aggcctagat
     2401 atatttttaa tatttggggc atgagcttcc cctgtttgag agttcccatt actgaggtag
     2461 aaatgttaat ttgctaaaca taatttgcta aaatgaccag ttttcagatt cacctgtgcg
     2521 tgtgccccca ctcgcacccc accccattct ctccatagaa cgtttgctgt cagctcggcg
     2581 gtctccattt cgaggtgttt atcagaagcg aggaggggag caaatgaagc cgtgctgccc
     2641 agccctcctc gtcttgtatt tgtttaggtt gtgaggttgt gtaaatagta gcttcctact
     2701 tgagaactac agctcctgct tatcattgat cctttcctgt ggcacttaat attttaattg
     2761 tcttaagctt ttgatgtaca tcctctggcc ccttacacgc tgccagagga gaaggtgttt
     2821 gagattcatt ccacttgaag tgtctttcct gggctcccca cagctgcaga tggctgggaa
     2881 gtggacttga ggaatgggct cgaattggtg gttcatgcct gtgaggaccc atcatgagtc
     2941 atcgggattt gtgttgcatg gaaggcaatc tttcctgttg taaatcttcc ttttttatgt
     3001 acatatattt tgaaaatatg aataaacatg aaattttaaa agctgctgaa ctacaa
//
LOCUS       NM_001436898            1802 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus ceramide-1-phosphate transfer protein (Cptp),
            transcript variant 3, mRNA.
ACCESSION   NM_001436898 XM_039110121
VERSION     NM_001436898.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Mishra,S.K., Gao,Y.G., Deng,Y., Chalfant,C.E., Hinchcliffe,E.H. and
            Brown,R.E.
  TITLE     CPTP: A sphingolipid transfer protein that regulates autophagy and
            inflammasome activation
  JOURNAL   Autophagy 14 (5), 862-879 (2018)
   PUBMED   29164996
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Simanshu,D.K., Kamlekar,R.K., Wijesinghe,D.S., Zou,X., Zhai,X.,
            Mishra,S.K., Molotkovsky,J.G., Malinina,L., Hinchcliffe,E.H.,
            Chalfant,C.E., Brown,R.E. and Patel,D.J.
  TITLE     Non-vesicular trafficking by a ceramide-1-phosphate transfer
            protein regulates eicosanoids
  JOURNAL   Nature 500 (7463), 463-467 (2013)
   PUBMED   23863933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110121.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.25887.1,
                                           SRR26643285.21769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000005.1  171760996-171761230 c
            236-1802            JAXUCZ010000005.1  171757181-171758747 c
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1802
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="ceramide-1-phosphate transfer protein"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
     exon            1..235
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    162..164
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="upstream in-frame stop codon"
     exon            236..1802
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..764
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="isoform b is encoded by transcript variant 3;
                     glycolipid transfer protein domain-containing protein 1;
                     glycolipid transfer protein domain containing 1"
                     /codon_start=1
                     /product="ceramide-1-phosphate transfer protein isoform b"
                     /protein_id="NP_001423827.1"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
                     /translation="MEHLRSGPQSEHYISLQSMVAYEVSNKLVDRDSRSRPRHPNSGC
                     RTVLRLHRALHWLQLFLEGLRTSSEDARTSTLCSEAYNATLAAYHSWIVRQAVNVAFH
                     ALPPRKVFLEAMNMGSSEQAVEMLGEALPFIEQVYDISQKLYAEHSLLDLP"
     misc_feature    <306..638
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
     misc_feature    <306..638
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
ORIGIN      
        1 aaccgcaggc tgcgagcttg ggggaaagca tagggatggg agctcttacc tgacagtgaa
       61 ctaggcagca gagccatgcc tctgtagacc accggaacgg agggcaaaga ttcgtcaccc
      121 acagcagcct aattatagct ttgatcaacc ccccccatca ctgaccttcc ctgcaccctt
      181 tgccctccgc gggagtaaag aaccaccact caccccccac cggaacccgt ctcaggtttc
      241 tgaacagcct aggggctgtc ttttcattca tctccaagga tgtggtctca aagcttcaga
      301 ttatggagca tctgagaagt ggcccacagt ctgaacacta cattagcttg caatccatgg
      361 tagcctacga ggtgagcaac aagctggtgg acagagacag ccgctcacgt ccccgacacc
      421 ctaactcagg ctgccggact gtgctgcgcc tacaccgtgc tctgcattgg ctacagctgt
      481 tcctggaagg cctgcgcacc agctctgagg atgctcgtac ctccaccctc tgcagtgagg
      541 cctacaatgc cacactggct gcctatcact cctggatagt acgtcaagct gtcaatgtgg
      601 ccttccatgc cttgccccca cgcaaggtct tccttgaggc catgaatatg gggtcctctg
      661 agcaagcagt ggagatgctg ggagaggccc tgcccttcat tgagcaagtg tatgacatct
      721 cccagaagct ctatgctgaa cattccctgc tagacctgcc ctagtagtgg taaccatact
      781 gtgtggactt cccctgctca gaactgggtt tgggcaatct agggctactc ccacagcagg
      841 gctttctgga aactactgtc acccctgtaa gctgaactgg tggaaagcca gtctgtgaaa
      901 agaaaggtcg tgggcagctg aaccaagaaa ggtgaatgct agtcatcctc ttggttcagg
      961 atgagacagt tgaactccag ttttgccctc cacttcagtc atgtgttcag tcaggcttga
     1021 ttgaagtgca gatggaaaat ggagaagtgg ggggcggtgt catgtatctg caacaaccca
     1081 aggttgctct acctctcctg tatagaatct gaaatggtat aaggacccag gacccaggag
     1141 ctgtcttccc tacagccaac atgcccagcc aatgtgtatc ctacatgtct ggggcccctt
     1201 catattccaa aagctgtaac atgggtaaca tgaagttcct ctggcagtgg catgagtccc
     1261 tgcccttcac ctgcttcctt gttagtctct ctgcatacca aacaggccct tgcctccttg
     1321 gaaatggaaa ctgtatgaaa ccaatagctg aggcttctct aagaaagcct gccctggtca
     1381 gtgcagcctg ttccacagct tctccagtat agtaccgtca gccttctgaa ggtggcttct
     1441 tacaacacat gtacccccag gattctaaga tgtcaatact aactggccaa accatacctc
     1501 tctctagcca gccctgctgc tcctgttgcc ataatacgca gatgacttag gacatgactt
     1561 gtgggaggag actaggcccc tttgtctgac agatggccat acctagcatg gctaataccc
     1621 agtgtataag accataagct ttcccactgg gtcttaatgt taaacccgag gacaatgccc
     1681 tcagcgtagc tgatgtgtgc aaatgcaaac tttggggggc acatctcttt ccttaagaat
     1741 tgtgatctat gtatttccaa cataaataaa ttacacctac atgattgggt atagcactct
     1801 gg
//
LOCUS       NM_001436928            6056 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3),
            transcript variant 2, mRNA.
ACCESSION   NM_001436928 XM_006251302
VERSION     NM_001436928.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6056)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 6056)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 6056)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 6056)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 6056)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 6056)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006251302.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.17304.1,
                                           SRR26643429.47255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  83684312-83684495   c
            185-320             JAXUCZ010000014.1  83674558-83674693   c
            321-369             JAXUCZ010000014.1  83628633-83628681   c
            370-454             JAXUCZ010000014.1  83627427-83627511   c
            455-532             JAXUCZ010000014.1  83614191-83614268   c
            533-622             JAXUCZ010000014.1  83611592-83611681   c
            623-739             JAXUCZ010000014.1  83611102-83611218   c
            740-822             JAXUCZ010000014.1  83604938-83605020   c
            823-989             JAXUCZ010000014.1  83602356-83602522   c
            990-1086            JAXUCZ010000014.1  83592224-83592320   c
            1087-1200           JAXUCZ010000014.1  83588725-83588838   c
            1201-1406           JAXUCZ010000014.1  83583226-83583431   c
            1407-1538           JAXUCZ010000014.1  83582300-83582431   c
            1539-1650           JAXUCZ010000014.1  83581721-83581832   c
            1651-1846           JAXUCZ010000014.1  83575932-83576127   c
            1847-2032           JAXUCZ010000014.1  83575039-83575224   c
            2033-2203           JAXUCZ010000014.1  83574230-83574400   c
            2204-2349           JAXUCZ010000014.1  83572847-83572992   c
            2350-3754           JAXUCZ010000014.1  83570317-83571721   c
            3755-3865           JAXUCZ010000014.1  83568961-83569071   c
            3866-3954           JAXUCZ010000014.1  83568438-83568526   c
            3955-3981           JAXUCZ010000014.1  83567729-83567755   c
            3982-6056           JAXUCZ010000014.1  83564065-83566139   c
FEATURES             Location/Qualifiers
     source          1..6056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..6056
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..184
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..320
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..369
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..454
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..532
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    515..517
                     /gene="Mtmr3"
                     /note="upstream in-frame stop codon"
     CDS             530..4153
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 2"
                     /protein_id="NP_001423857.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MDEEMRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEY
                     VGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFP
                     TFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRN
                     SCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWL
                     DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNM
                     VPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQE
                     PQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVE
                     NIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSE
                     SGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAP
                     CALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSH
                     QLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQR
                     LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQN
                     CLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRDTDR
                     VDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAA
                     TSN"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    3872..4081
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    3872..4081
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    order(3875..3877,3884..3886,3938..3955,3986..3991,
                     4061..4069)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     misc_feature    order(3875..3877,3884..3886,3938..3955,3986..3991,
                     4061..4069)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     exon            533..622
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..739
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..989
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1086
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1200
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1406
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1538
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1650
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1846
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2032
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2203
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2349
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3754
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3865
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..3954
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..3981
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..6056
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccgc tgccgccatg ttgttgtggt tgtgagaagg cggcggcggc agcggtggcg
       61 gcggagcagc cggtggagac gctccagcgg cccaggcgct gccccccgcc gaccctggct
      121 ggcagcctcc tggggtggcg gaggaggccg tgcggtggcg ggcctcgcca tgtcctgcct
      181 cccgagtacc tggtgacctg ttttgactct ccatttggaa gggcctggtc tgtaccattg
      241 taaacatgct ttaccgagtt gtgatgactg ctcctcctcc ttgtttttgg cctgggaact
      301 gagcccaagg tcttatccag atttccttgt aaaaccttgt agaagaaaaa gttctcagga
      361 agatacttgt gcatcggagt cagaggctgg tgcaagctgg ctagccagag aaccaaatca
      421 gtgaaccccc agttctacag cagatcctgc cttagtctca agcagaagag aaagaagaac
      481 cttgtcagag actggagaag gacggggtct ctcctgacct ggtctggtca tggatgaaga
      541 gatgcggcat agccttgagt gcatccaggc caatcagatc tttcccagga agcagctgat
      601 tcgggaggat gaaaatcttc aggttccttt ccttgaactc catggagaga gcacagagta
      661 tgtgggccgt gctgaggatg ccatcattgc cctctctaat tacagacttc acatcaagtt
      721 taaggagtct cttgtgaatg ttccattaca gcttatagaa agcgttgaat gccgtgatat
      781 atttcagctt cacttgacat gcaaagactg caaagttatc aggtgtcagt tcccaacctt
      841 tgagcagtgt caagattggc ttaagagatt aaacaatgca atccgaccac ctggaaaaat
      901 agaagatctc ttctcatttg cataccatgc ttggtgcatg gaggtctatg ccagtgaaaa
      961 agagcagcat ggagacctgt gcagaccagg ggaacatgta acgtcaaggt ttaagaatga
     1021 agtggagcgg atgggttttg atatgaacaa tgcctggagg atttccaaca tcaatgagaa
     1081 atacaaatta tgtggtagtt atccacaaga gctcatagta cctgcctgga tcactgacaa
     1141 agaactagaa agcgtggcag gcttcagatc ctggaagcgc atccccgccg tcatctacag
     1201 gcaccagagc aatggagccg tcattgcccg ctgcggacag cccgaggtta gctggtgggg
     1261 ctggcggaat gctgatgatg aacatctggt gcagtcagtg gccaaggctt gtgcttctga
     1321 ctctcagtca agtgttggca aggtttccac tcggaacagt tgtcggggct ttcccaatgc
     1381 aggggatctt tctgatgtgg agttcgatgc ctctctgtca aatgcttcag gaacagaaag
     1441 tttagctctc cagccacaga agcttttgat cttggacgca cgctcctatg cagcagctgt
     1501 ggcaaatcga gccaaaggag ggggctgtga gtgtccagag tattatccaa actgtgaagt
     1561 tgtgtttatg ggaatggcaa acatacattc tatccggagg agtttccagt ctctgcgact
     1621 gctgtgcaca cagatgccag atcctggaaa ttggctttct gctcttgaaa gtacgaagtg
     1681 gctccaccac ctgtctgtgc ttctgaagtc ggcacttctc gtggtgcatg ctgtggaccg
     1741 agatcagcga ccagtgctgg tgcactgctc agatggctgg gatcgcactc cccaaatcgt
     1801 ggccctggct aagcttctgc tggaccctta ttaccgaacc gtagagggtt tccaagtcct
     1861 tgtggagatg gaatggctgg attttggcca taagtttgct gatcggtgtg gtcatgggga
     1921 gaactcagat gacctgaatg agcgttgccc agtgtttctc caatggcttg actgtgttca
     1981 tcaactccag aggcaatttc cttgctcttt tgagttcaac gaagcattcc ttgtgaagct
     2041 ggttcagcac acctattcct gtctctttgg gacattcctg tgcaacaacg ccaaggagag
     2101 gggggagaag cagactcagg aacggacatg ctcggtgtgg tcgcttctgc gggccggcaa
     2161 caaggccttc aaaaacctgc tatattcatc ccagtcagaa gccgtgctgt accctgtgtg
     2221 ccatgtgcgg aatctgatgc tgtggagtgc agtgtacctt ccctgcccgt ccccatccac
     2281 ccccacagac gacagctgtg caccataccc agccccaggc accagccctg atgagcctcc
     2341 actgagccgg ctacccaaga ctagatcatt tgacaatctg accacaacct gtgacaacat
     2401 ggtgccgctg gccagccggc gcagcagtga ccccagcctg aatgagaagt ggcaggagca
     2461 cgggcgctcg ctggagttga gcagctttgc tggctctggg gaagaggtgc ctgccataga
     2521 cagcctgcgc aggcccagca ggctgctcgg aggagccgag ctatctgtgg cagctggtgt
     2581 ggctgaaggg cagatggaga atattttgca agaggccacc aaagaggaga gtggggtaga
     2641 agagcccacc cacagggagc acactgaggt gccagaggtc aaagaggagg cacccctagc
     2701 aaaagagagt aggacggcag ctcagggctc aggtgtactt taccaagaac cacagctgga
     2761 tgatgctact ctaaggagcc atttaggccc cagcctgtct tcgttctccc agggtattcc
     2821 tgagcatcgg gaggtggggc acagtgttct ctctagttca ctcccagctt ctctcagggg
     2881 agaggactcc caggaggtcc ctgtagaaca gcctcaagta gagaacattg cagaggacag
     2941 ggagaatgta gtccctgctg tcccagtaga tgtaaaaatt ggccttggta cctcagagtc
     3001 tagtcctctg ctgccttccc aagtcccatt cgagacaaga ggaccacaca tgaacaactc
     3061 cgtgcacatg ttattagaag ataaggtgaa gtccgagagt gggccccagc tccatcacag
     3121 accctgcctg gcaagcagtg gtagattcag tggcaaggac atgcttccta tagcaccaga
     3181 gcccaggtct gctgagaggc cccagtggga ctctgtgcta cacaggactt cttcccctgg
     3241 caacaccctc agcctgatga tgcaggctcc ttgtgccttg ccattagaca aatgtagaca
     3301 gagaattgtg tgcaacggtg ccctagagac tgaaaacaag gcctcagaac agcctgcagg
     3361 gtttgacacc cttcagaagt accccacacc caatgggcat tgtgccaatg gggagactgg
     3421 gaggagtaag gactcactga gccaccagct gtctgccaca agctatagct ctgctcactc
     3481 gtgctcaagg aacttgcacc acaagtggct gaatagccac tcggggaggc catccactac
     3541 caacagccct gagcagcctt cccgcagcca cctggatgat gacggcatgc ctgtgtacac
     3601 agacacgatc caacagcgcc tgcgacagat agagtctggt caccagcagg aagtggagac
     3661 cttgaagaaa caagtccagg aactgaagag tcgcctggag agccagtacc tgaccagctc
     3721 tctgcgcttc aatggggact ttggagatga agtgacttca atccccgact cggaaagcaa
     3781 tctggatcag aactgtttgt ctcgctgcag cacagagatt ttctctgaag ccagctggga
     3841 gcaggtggat aaacaggaca cagagatgac ccgttggcta cctgaccact tggctgccca
     3901 ctgctatgcc tgtgacagtg ccttctggct tgccagtagg aagcaccact gcagggacac
     3961 tgaccgtgtt gatcaaacgt ggaattgtgg gaacgtattc tgctccagtt gttgtaacca
     4021 gaaggttcca gttcccagcc agcagctctt tgaacccagt cgagtgtgca agtcttgcta
     4081 tagcagcctc catcccacaa gctccagcat tgaccttgaa ctggataagc ctattgctgc
     4141 cacttcaaac tgaagctcag tgacctgggg tgacagaggc catgctgctg tccctgtaac
     4201 aggctcacac acagcctggg cagtccgaga agcccataca ttttggatgg gggcatggaa
     4261 caacctgtac agagattggg gtgtaccact ggatcgtaga tcgattttcc tttccttccc
     4321 cttccctttc catcctcctc tttgccttct aaaaagaaaa atgtcccagt tgtcttaatt
     4381 ttttttaatg gaagcccaga ggttaccagg ctcttagaac tgctgagtgg cttgctgtcg
     4441 ggcactctgt gacatcactc agtgcttccc tatggaagga ggcacaatga aggcctgaga
     4501 cagcaggaca gaaagccagc ctaccattaa tgaccgttct ccacatgaag ctgtgccaca
     4561 gttgactggt gcacctttgc agctggggag gctggaagcc cttttcttga gtactgttcc
     4621 tcagagggat agatagggcc atcctacctc acagacaaaa agcaggatgg tgttgagagg
     4681 aagcacacag tgaagtgctc cacaggcctc actttgaaaa gagaggtatg tgcttctttt
     4741 gagttactga gggcctagat ggctgacatg ttggcccagg tggatccatc tttaacaaga
     4801 ttgggtaggg ctttctttgc ttctttaggc ttccagacca aaaggtacag actggccaga
     4861 aagcagtatc ctgctgcagt ggtcaaggcc tgcactgagc tgggcacctg aggtccccct
     4921 ctgggtccta gtcccataag caatctcttc ctcagccaac acagggaaat ccagactcag
     4981 ggttccacag tctcctgttc ccaaagcaaa ccaatcatgc atctcccctt gagggacaga
     5041 tccccacagt tccgaagctc tccacacaat cagccttcct ctcttacttc tgggcagcag
     5101 gaaggaccca ggagtccctt gtcctgcttt tggctgcctg agtgggcaca tgtctggctc
     5161 ttgctatcag tgaagagccc ttggtgattg tagggttctt agaagatgac atggctgagg
     5221 agattcgggg taccttcccg tagtgagctt tgatgtggtc caaaaagagc cttaagtctg
     5281 tagttatctg tgctggaggt gggtatgaag ggtagagagc agttttggtt tgtactttga
     5341 attgttggca tctgtctgtg cccaccccat cccccaaggg tgatgcttgg ctctgccaaa
     5401 agctgcaatc tggtaacaga gcagattata gtgttggggc tgggtgaggc tgggtgaggc
     5461 tgggggacac ctaattttag cctggcctat gtccttgctc ctctcctctg gaagctgtta
     5521 cctggccatg ggccttccgt gtctcaggaa ggtggcttct gcatgttcct cagtatgact
     5581 ggagaagcca gagccttccc agcagttgtg tgctgaaggg aaggctgcag tctccgagta
     5641 ttgctggtcc ttcaggagca ggccgggcag aggccgagtt tagtgaaaca gggtgaagtt
     5701 ctccaagctc gctgtggtct ggagttgcgg gtggggaagg tcggcataac tgaagactgc
     5761 agttcctagt gagaggtgcc aagaggttat gatacgggtg tcttgggtct gttgtacagt
     5821 gtgaataagt gcttgcagct cttagccctt tttgatcaat gaagcacttt tttattaata
     5881 ttttctttgt atgtaaagga ggaaccgtaa ctctccatag ctgtacatat aacccctttc
     5941 tcctaaagag gagtccgtgc tcctatattt ttcatttttt gtcaaagcaa gaagtaaata
     6001 ctttagaatt gttaaataca tagataaagt gaataaagtt gagtgtcagc aaggtg
//
LOCUS       NM_199108               3250 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 1, mRNA.
ACCESSION   NM_199108 XM_233579
VERSION     NM_199108.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_199108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061837.1, SRR26360194.2463005.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000005.1  155719134-155719237
            105-298             JAXUCZ010000005.1  155724378-155724571
            299-398             JAXUCZ010000005.1  155724942-155725041
            399-552             JAXUCZ010000005.1  155726205-155726358
            553-712             JAXUCZ010000005.1  155728962-155729121
            713-856             JAXUCZ010000005.1  155732660-155732803
            857-934             JAXUCZ010000005.1  155734814-155734891
            935-1086            JAXUCZ010000005.1  155735359-155735510
            1087-1177           JAXUCZ010000005.1  155738870-155738960
            1178-1337           JAXUCZ010000005.1  155740995-155741154
            1338-1449           JAXUCZ010000005.1  155742543-155742654
            1450-1566           JAXUCZ010000005.1  155743955-155744071
            1567-3250           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3250
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..104
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..298
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    200..202
                     /gene="Hp1bp3"
                     /note="upstream in-frame stop codon"
     CDS             203..1864
                     /gene="Hp1bp3"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform a"
                     /protein_id="NP_954539.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MATDMSQGELIHPKALPLIVGAQLIHADKLGEKADDSTMPIRRA
                     VNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPENETPPAPSREAEQPKGEPES
                     GEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLSASQLARAQKQTPMASSPRPK
                     MDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLERRGYLLKQALKRELNRGVIKQ
                     VKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVKLEDVLPLAFTRLCEPKEASY
                     SLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPL
                     LGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKN
                     GWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSEDEDEEEDEEESSEDSEDEEP
                     PPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRGKVRPLPKKAPPKAKTPARKG
                     RPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKKKSFKTKK"
     misc_feature    206..208
                     /gene="Hp1bp3"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); acetylation site"
     misc_feature    218..220
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    290..595
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    353..355
                     /gene="Hp1bp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    455..457
                     /gene="Hp1bp3"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    626..628
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    665..919
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    665..919
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    665..667
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    668..670
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    order(686..688,722..724,818..820,860..862)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(686..688,722..724,818..820,860..862)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    770..772
                     /gene="Hp1bp3"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q3TEA8; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); acetylation site"
     misc_feature    803..838
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    803..838
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    893..955
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    941..943
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    959..973
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: PxVxL motif.
                     /evidence=ECO:0000250|UniProtKB:Q5SSJ5"
     misc_feature    992..1174
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    992..1174
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1220..1423
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1220..1423
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1466..1861
                     /gene="Hp1bp3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P747.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1523..1525
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    1526..1528
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    1535..1537
                     /gene="Hp1bp3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6P747.1); phosphorylation site"
     misc_feature    <1607..>1831
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1607..>1831
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            299..398
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..552
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..712
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..856
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            857..934
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1086
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1177
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1337
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1449
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1566
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..3250
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcggt gcccggcctg gaggacagcg gtgtcggagt cagcgatcgg tggtccgcag
       61 caacgctgag gggccgtacg ggacgcaggc gccggagctc agaggttgac tcttcaccac
      121 actgaagcca ttaggaaacc cctgtgatta acagcagagg cttcagagtc tcaccagtat
      181 tcaggcctag actttatttt aaatggcaac tgatatgtct caaggtgaac tcatccatcc
      241 taaggcactc ccacttatag taggagctca gctgatccac gcggacaagt taggtgagaa
      301 agcagacgat agcaccatgc ctatccgtcg ggctgtgaat tctactcggg aaactccgcc
      361 caaaagcaaa cttgctgaag gggaagaaga aaaaccagaa ccagatggga gttcagagga
      421 gtctatctct acggtagaag aaccagagaa tgagactcca cctgctccat ccagggaggc
      481 agagcagccc aagggggagc ctgagagtgg agagaaggaa gagagcaagt ctgctgagga
      541 aaccaagaaa gaagagaagg atcagtctaa agaaaaggag aagaaagtga agaaaaccat
      601 ccctgcctgg gccactctgt ctgccagcca gctagccagg gcccagaaac aaaccccaat
      661 ggcttcctcc ccacggccaa agatggatgc aatcttaact gaggccatta aggcatgctt
      721 ccagaagagc ggtgcctccg tggttgctat ccggaagtac atcattcata agtacccttc
      781 tctggatctg gagagaaggg gctatctcct caagcaagca ctgaaaagag agttaaacag
      841 aggagtcatc aaacaggtaa aaggaaaagg tgcatctggc agttttgtcg tggtccagaa
      901 atcaaaaaca cctcagaaat ccaaaaacag aaagaagggc tctgcagtgg atccagaacc
      961 acaagtaaaa ctggaagatg ttctcccatt ggcttttacc cgactctgtg aacctaagga
     1021 agcctcctac agtctcatca ggaaatacgt gtctcagtat taccctaagc ttcgagtgga
     1081 catcaggccc cagttgttga agaatgctct gcagagagca gtggagagag gccagttaga
     1141 gcagataact ggcaagggtg cttcggggac attccagctg aagaaatccg gggagaaacc
     1201 cctgcttggt ggaagcctga tggaatatgc aatcttgtct gccattgctg ccatgaatga
     1261 acctaagacc tgctccacca ctgctctgaa gaagtatgtc ctggagaacc acccagggac
     1321 caattctaac taccaaatgc atttgctgaa aaaaactctg cagaaatgtg agaagaatgg
     1381 gtggctggag cagatctctg ggaaggggtt cagcggcacc ttccagctgt gcttccccta
     1441 ttaccccagc ccaggagttc tgtttccaaa gaaagtgtca gatggctctg aggatgagga
     1501 tgaggaggag gatgaagagg agtcatcaga ggactctgag gatgaagagc cgccacccaa
     1561 gaggagctta cagaagaaaa caccagccaa gccccaaggg aagacggcct ccatgaagca
     1621 gagaggggct aagcctgcgc gtaaagtccc tgctgcccag agagggaagg tgaggccgct
     1681 gcctaagaaa gctccgccca aggctaagac ccctgccagg aaaggcagac ccgcaccctc
     1741 agccgtcaag aagcctagcg ggagcacctc caaaaagcct gtagccaatg cacgaaagga
     1801 agcgaaactg cccggtaagg gcaaatctgc catgaagaag aagtctttca agacaaaaaa
     1861 gtaaatttta taggaaaaag ggtatcatga ttgaattcag aatcttattt tataaggtca
     1921 gtgtgcattt gttttagtta taatgctttt aaattttaca tttttcttcc catacgaaca
     1981 ctgtgggaag gaatgtaaac aaaccagtgt agacatttgt tggcttaggt gctgttctca
     2041 gtgcctgctt cttcatcatt ttaatttctg ccgtaatcct ggacttggct gaactgtgta
     2101 actaccctgc tccctttgtt catcttaacc caaccctcat tctcttcttt ttgtgatcca
     2161 atttggggtt ttcttttcct cctcgaagtt aatccaaaca gttgcaaaga tgcatttgta
     2221 gtgagtacct ccaggtctgg tgctgaagcc agacggagcg ggagcactac agggacagca
     2281 ttgcttcctg cctggggact tgctgattga ccctggctgt gaaatcactc cactaacctt
     2341 tctccagcgt gggccaggga cattataact ttggaaagaa gccccagtct gccatccata
     2401 gattctgaag atctcttctc ctttgctgtc tgcccagttg ccaagcacgc cctgctgccc
     2461 agagcgttgt tcccttaaca gcaagcgcac gtctgcgcca cctgctttct gactgaaggg
     2521 gaagtacagg aatatgtgga atctgattgc ttattaccaa aaatgacaga atattcttga
     2581 tcaaaggcct agatatattt ttaatatttg gggcatgagc ttcccctgtt tgagagttcc
     2641 cattactgag gtagaaatgt taatttgcta aacataattt gctaaaatga ccagttttca
     2701 gattcacctg tgcgtgtgcc cccactcgca ccccacccca ttctctccat agaacgtttg
     2761 ctgtcagctc ggcggtctcc atttcgaggt gtttatcaga agcgaggagg ggagcaaatg
     2821 aagccgtgct gcccagccct cctcgtcttg tatttgttta ggttgtgagg ttgtgtaaat
     2881 agtagcttcc tacttgagaa ctacagctcc tgcttatcat tgatcctttc ctgtggcact
     2941 taatatttta attgtcttaa gcttttgatg tacatcctct ggccccttac acgctgccag
     3001 aggagaaggt gtttgagatt cattccactt gaagtgtctt tcctgggctc cccacagctg
     3061 cagatggctg ggaagtggac ttgaggaatg ggctcgaatt ggtggttcat gcctgtgagg
     3121 acccatcatg agtcatcggg atttgtgttg catggaaggc aatctttcct gttgtaaatc
     3181 ttcctttttt atgtacatat attttgaaaa tatgaataaa catgaaattt taaaagctgc
     3241 tgaactacaa
//
LOCUS       NM_001107228            1965 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 53, member A
            (Fam53a), mRNA.
ACCESSION   NM_001107228 XM_001062281 XM_223544
VERSION     NM_001107228.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1965)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1965)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001107228.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168895.1, SRR26643286.39035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000014.1  81315414-81315676
            264-389             JAXUCZ010000014.1  81316037-81316162
            390-622             JAXUCZ010000014.1  81330648-81330880
            623-677             JAXUCZ010000014.1  81335761-81335815
            678-1441            JAXUCZ010000014.1  81338425-81339188
            1442-1965           JAXUCZ010000014.1  81348407-81348930
FEATURES             Location/Qualifiers
     source          1..1965
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1965
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="family with sequence similarity 53, member A"
                     /db_xref="GeneID:305461"
                     /db_xref="RGD:1563315"
     exon            1..263
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            264..389
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            390..622
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    527..529
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="upstream in-frame stop codon"
     CDS             545..1753
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /codon_start=1
                     /product="protein FAM53A"
                     /protein_id="NP_001100698.1"
                     /db_xref="GeneID:305461"
                     /db_xref="RGD:1563315"
                     /translation="MVTLITEKLQNQSLDDLTRRACEAVPYSAEKLDKSGHLFPLEIG
                     VDKSPWKASHGGWPFRSRAASGPFSVGPHGVSHTEGLKWQLESPGPMAVGRFLDLRES
                     TGPPAAPPTKRHCRSLSEPEELARCRSPWRPGSSKVWTPISKRRCNSGGSATLQCCSG
                     LGNPALQGSLAPGLPRKPVSPTGPTSPMTPRPASASSGFVDGSEGSTSSGPPWLSTGP
                     CPFSSRRRLSLSQEHLVDAGACLPSASSTPTSTPELGRHHGLLRCRSQPCVLDGRRVR
                     RKRRREEDARWTRPSLDFLKMTRTLKNSKSLCSLDYEDDEDDTQAKTVVSSPCNSQGL
                     VGIITPSSSPRIPRPGPASPSVWASGEPETSTGEGGSSGEPSDWDSAGEEGIFPLDHG
                     DLDLEQIENN"
     misc_feature    545..1441
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="Family of FAM53; Region: FAM53; pfam15242"
                     /db_xref="CDD:464582"
     misc_feature    545..1441
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="Family of FAM53; Region: FAM53; pfam15242"
                     /db_xref="CDD:464582"
     exon            623..677
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1441
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1965
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcggag cgcggcctgc gcggccggcg ccttgcccca gctacggagc ccggtgctca
       61 cccgtcgcgc ggacattgct ctgtgccgtc gttcgcctgc ccatcgctaa gagctccatc
      121 caccggaacg ccgtgtcctt gcgctgtaag cccggaatct ccgtacgtcg gccggcgccg
      181 cgcagccgca cgtcgagagc cgggtgcatc gccacagcgc gcggaacacc ctctaggtcc
      241 ggccggcacc tcagcacctt aaggaagcag gaagtttgac gagatatgat ggtcccttaa
      301 gagaatccca agagcagatc ctccccgacg tcctgtggaa ggtgacttgg aagtgtattc
      361 cgaagccact tttctgcgta gactgaaggt gacaaagccc tgaagagtct gcaaatgggt
      421 cagcatcttt aagtcagagc tataaccctg agctttggct cagacctgat ggcttgagcc
      481 tgctgatgtc caggcttctg gaaatccagt gcccatagat gtggactaag gaagagcccc
      541 gaccatggtc actctcatca cggagaagct gcagaaccag agtttggatg accttacccg
      601 aagggcctgt gaggctgtcc cgtattctgc tgagaaactg gacaaaagtg gccatttgtt
      661 ccctttggag attggcgtgg ataaaagtcc ctggaaggcc tcacatggag gatggccctt
      721 tcgaagccgg gcagcctcag gccccttctc agtgggccca catggtgtgt ctcataccga
      781 aggtctcaag tggcagctgg aatccccagg gcccatggct gtgggccgct tcctggacct
      841 ccgtgagagc acagggccac ccgcagctcc accaaccaag cgacactgcc ggtccctgtc
      901 agagccagag gagctggctc gatgccgttc cccatggcgc cctggtagct ccaaggtgtg
      961 gactcccatc tctaagagga gatgcaacag tggcgggagt gccacgctgc agtgctgcag
     1021 tggtctcggc aaccctgcac tgcagggcag tctagccccc ggcctaccca ggaagcctgt
     1081 gtcgcccacc ggccctacct caccgatgac gccccggcca gcttcagcca gcagtggctt
     1141 tgtggatggc agtgagggca gtacgagctc aggtccaccc tggctttcta caggaccctg
     1201 cccattttcc tccaggcgcc gactgtccct ctcacaagag caccttgtag atgcaggtgc
     1261 ctgcctgcct tccgccagca gcacccccac ttccacacct gagctaggcc ggcaccatgg
     1321 cctgctccgg tgccgctcac agccttgtgt gttggatggg aggagggttc ggcgcaagcg
     1381 gagacgggag gaggatgcca ggtggacgcg cccatccttg gactttctga aaatgactcg
     1441 gactttaaaa aactcaaaga gcctttgttc cctggactat gaagatgatg aggatgacac
     1501 ccaggcgaag acggttgtgt cctctccgtg taactcgcag ggcctcgtgg gcatcatcac
     1561 tcccagctct agcccaagga ttcccaggcc tggccctgcc agccccagtg tctgggcttc
     1621 aggggagcca gagactagca ccggtgaggg tgggagcagt ggggaaccca gtgactggga
     1681 cagtgcagga gaggagggca ttttcccgct ggaccacggc gacctggact tggagcagat
     1741 tgagaacaac tgattttggc tgagcagtgg ctgctgtctg tcaccttggt gcctgaccag
     1801 tggaaagaac ttgtgtgtta ttttgaaaat tgaggtgtaa ttttgattca gtttttccta
     1861 aagaagtatt ttgcattttt atggcttcta cagtttggga gagcatctct attttgaaat
     1921 gggtttttag agggcattct attaaacatg gttctacgta cattc
//
LOCUS       NM_001108654            4016 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus thymocyte selection-associated high mobility
            group box (Tox), transcript variant 2, mRNA.
ACCESSION   NM_001108654 XM_001063218 XM_342800
VERSION     NM_001108654.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Artegiani,B., de Jesus Domingues,A.M., Bragado Alonso,S.,
            Brandl,E., Massalini,S., Dahl,A. and Calegari,F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Yun,S., Lee,S.H., Yoon,S.R., Kim,M.S., Piao,Z.H., Myung,P.K.,
            Kim,T.D., Jung,H. and Choi,I.
  TITLE     TOX regulates the differentiation of human natural killer cells
            from hematopoietic stem cells in vitro
  JOURNAL   Immunol Lett 136 (1), 29-36 (2011)
   PUBMED   21126536
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Aliahmad,P. and Kaye,J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001108654.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.248158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000005.1  24968579-24968754   c
            177-312             JAXUCZ010000005.1  24967582-24967717   c
            313-378             JAXUCZ010000005.1  24822463-24822528   c
            379-621             JAXUCZ010000005.1  24803320-24803562   c
            622-903             JAXUCZ010000005.1  24722995-24723276   c
            904-1134            JAXUCZ010000005.1  24706495-24706725   c
            1135-1215           JAXUCZ010000005.1  24694150-24694230   c
            1216-1599           JAXUCZ010000005.1  24681968-24682351   c
            1600-1751           JAXUCZ010000005.1  24674144-24674295   c
            1752-4016           JAXUCZ010000005.1  24671564-24673828   c
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..4016
                     /gene="Tox"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
     exon            1..176
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            177..312
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    196..198
                     /gene="Tox"
                     /note="upstream in-frame stop codon"
     CDS             211..1788
                     /gene="Tox"
                     /note="thymocyte selection-associated HMG box"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_001102124.1"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
                     /translation="MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPVSQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMQEIGNAEGAQYSSHPQLAAMRP
                     RGQPTDLRQQASMMQHGQLTTINQSQLSAQLGLNMGGTNVPHNSPSPPGSKSATPSPS
                     SSVHEDECEDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYNDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQPLVQQPLASQLPM
                     QVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWST
                     DYCSSGGMQRDKALYLT"
     misc_feature    994..1203
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    994..1203
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    order(994..999,1003..1017,1024..1029,1048..1050,
                     1084..1089,1096..1098,1105..1110,1129..1131,1141..1143,
                     1150..1152,1162..1164,1171..1173)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     misc_feature    order(994..999,1003..1017,1024..1029,1048..1050,
                     1084..1089,1096..1098,1105..1110,1129..1131,1141..1143,
                     1150..1152,1162..1164,1171..1173)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     exon            313..378
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            379..621
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            622..903
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1134
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1215
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1599
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1751
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..4016
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taactccagg agcactgctc atcgcactgc gatcagctgg ggtcccttgg tcagttgccc
       61 actagcatga agcagaggtt gcgctccctg caggctccgg agcagcgcta cgggacaccc
      121 tctcctctac ctcccgcgtg gtacagaggt tggcagtgca gctactccag gcgggagaaa
      181 agaaaaggag ttgcttgatg tgagagtgaa atggacgtaa gattttatcc acctccagcc
      241 cagcccgctg ctgcgcccgc cgctccctgt ctgggacctt ctccctgcct ggacccctac
      301 tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc gagccaggac
      361 tatgtgccag tcagccagtc ctaccctggc ccaagtctgg aaagtgaaga ctttaacatc
      421 ccacccatta ctcctccctc actccctgac cactctctgg tgcacctgaa tgaggtggag
      481 tccggttacc actctctgtg tcaccccatg aaccacaatg gcctgcttcc attccatcca
      541 caaaacatgg acctgccaga gatcaccgtg tccaacatgc tgggccagga tggcacactg
      601 ctctccaatt ccatctctgt gatgcaagag attggaaatg ctgaaggagc tcagtacagt
      661 tcccatcctc agctggcagc catgaggccg agaggccagc ctacagacct cagacagcag
      721 gcaagcatga tgcagcacgg ccagctgacc accatcaacc agtcacagct gagcgcacag
      781 ttgggcttga acatgggagg aaccaacgtc ccacacaact ccccttctcc acctgggagc
      841 aagtctgcaa ccccttcgcc ttccagctcg gtgcatgagg atgagtgtga ggatacctcc
      901 aagatcaatg gaggagagaa gcggcctgcc tctgatatgg gaaaaaaacc aaaaactcct
      961 aaaaagaaga agaagaagga tcctaatgag ccccagaagc ctgtgtctgc ctatgctttg
     1021 ttctttcgtg atacccaggc tgccatcaag ggccaaaatc caaatgctac ttttggtgaa
     1081 gtctctaaga ttgtggcatc catgtgggat ggcctaggag aagagcagaa acaggtctac
     1141 aagaagaaaa ctgaggctgc aaaaaaggaa tacctgaagc agctagcagc atacagagcc
     1201 agccttgtat ccaagagcta caatgaccct gtggatgtta agacatctca gccaccccag
     1261 ctggtcaact ccaagccgtc agtgttccat gggcccagcc aggcccactc agctctgtac
     1321 ctaagttctc actatcacca acaaccagga atgactcctc agctcaccgc catgcatccg
     1381 agcctcccca gaaacatagc acctaagccc aataaccaaa tgccagtgac tgtctccata
     1441 gccaacatgg ctgtgtcccc accaccgccc ctccaaatca gcccacctct tcatcagcat
     1501 ctcagcatgc agcagcatca gccacttgtg cagcagcctc ttgcgagtca gctccccatg
     1561 caggtccaga ccgccttaca ctcgcccacc atgcagcaag gatttactct ccaacccgac
     1621 tatcagacta ttatcaaccc tacatctaca gccgcacaag ttgtcaccca agcgatggag
     1681 tacgtgcgtt ctgggtgcag aaatcctccc ccacagccgg tggactggag taccgactac
     1741 tgcagtagtg ggggcatgca gagggacaaa gcgctgtacc tcacctgaaa atctcaacac
     1801 ctctcctttc cactgaggaa ttcagggaaa ccttttcacc acggattgct ttggccgctc
     1861 aaagcagttc ttcattttat tagaaaatac aagttgctaa gcacttagga ccatgtgagc
     1921 ttgtgggtca cccacgctgg aagaaatagt catgcttctt tattattttt ttaatctttt
     1981 atggacattg tccctcttcc ctgaaggaag tatgggccat tcagatttct gttggttttg
     2041 ctgtgaagtg ctgccgctct agtaactgcc ttagcaacgg tagatgtctg gggtaaaacg
     2101 gtcctgggtt ttccattggt tttcataatg ggtgtttata tgaaactact aaagactttt
     2161 taaatggctt gatgtagcag tcatagcaag tttgtaaata gcatatatgt tacactctcc
     2221 tagagtataa aatgtgaatg tttttgtagc taaattgtaa tttgaaactg gctcacccca
     2281 gtttgttgat ttcagagggg ttaaattggc aaacattcat atttttactt catttttaaa
     2341 aagaaaaaaa acaactgact gatagttcta tattttcaaa agacttgaaa actattccca
     2401 aatcatttta atttaaaaac aaattggctt tgtcttattg atcagacaaa aggaagctct
     2461 cgtgtggagg gaagcgcaaa cacatttatt ttgtattgca ggaaaaaaat tcttttttgt
     2521 atcacttttg tgtaatggtt agtaagcgtc atctaagtcc ttttatgtat aaaactgcca
     2581 aatgctcgcc tggtatctta gctgcagaaa caggtcaaac agcgctaagt gatcaccgtt
     2641 acctgtggct ctgtgttact gttccctcat ccgtgtctgt atttaatcgt tttcttctct
     2701 ttttttttta atgaaacttg tttcgcttat ttatgaaata ataaatatag gtgtttgtaa
     2761 gtaaatttgt tagtatttga aagaggtttt gttgatgctt taatttttgc tggcaaaaaa
     2821 gaaaaaaaat ccatgcttgg tgtgaatatt tagtttttac agtgacatga ataaaaccaa
     2881 aactgctttt catttagtag caaaatagag tgacgaatct gtatttttgc atatcttttg
     2941 ttgacataaa tgaaaaacaa ttctacttag ccatcttctt ctcttgaaca atacaacaga
     3001 aaattgccct ggagatctca cacttgccaa gcctaagcaa acaccagtgc atcccgttcc
     3061 taaaaagata cgaagagcta tttttcactt ctccattcca aaacatttaa ccaccaccac
     3121 cacaccacac acacccgcta aaaaccaaat tcaagttgag tcactcaaaa ttcctcaagc
     3181 cacatgcttc tcatagcatg cagaaaacat ttaagaattg accaagggtt caggaagagg
     3241 tcaaagaagg atatcatgtc taggatcaat ctagaaatga aggactagta accagatcag
     3301 ctatagaaat aggaaaaaca tggaaaccgg aagcagttgc tagaaactgt gaaatctgct
     3361 gtccctctcc cctctactct cttcttcctc ttctatgcat cctgagtccc tgtaagagat
     3421 ttgcctgaag gtgtttgcat agttctgata gcagaaggga agggtgagga aatgtttccc
     3481 ttccacgggc ttctgtcacg taaattcatc tggctggaca tgaagagaat gattgttttg
     3541 cggaatgaaa taacctcaac aatttaaata caaatatatc atgtaatcca gtcaaaatta
     3601 aaaagacaaa agtcttgctt gctttggatt ggtttttcag acactgtgcg agttgaatca
     3661 cttggcatgt aatgactaat aaataatgca cattcagtgt tattattaaa atggccgggg
     3721 tcgagagctc aaattttcct gtcttgatac tgtataagaa ttcgtgtgat taacttccca
     3781 gtttattgtt tggctgttta gtattttaga aatataccag cattattaat taactaatgc
     3841 cttttattat tgtattatga taaaatatta ctttctccta cattaagtcc aaactgagaa
     3901 gagtccgacc agctaagata agaggtgtat caggagattg tctgcagctt ttcctggcag
     3961 gcgaaaagaa aaaaatacat caaatgtgaa ataaattatc aattaaactc tcactg
//
LOCUS       NM_001436858            3054 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 8, mRNA.
ACCESSION   NM_001436858
VERSION     NM_001436858.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.132270.1,
                                           SRR26360194.2137449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050754, SAMN17050766
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000005.1  155719134-155719237
            105-204             JAXUCZ010000005.1  155724942-155725041
            205-358             JAXUCZ010000005.1  155726205-155726358
            359-516             JAXUCZ010000005.1  155728964-155729121
            517-660             JAXUCZ010000005.1  155732660-155732803
            661-738             JAXUCZ010000005.1  155734814-155734891
            739-890             JAXUCZ010000005.1  155735359-155735510
            891-981             JAXUCZ010000005.1  155738870-155738960
            982-1141            JAXUCZ010000005.1  155740995-155741154
            1142-1253           JAXUCZ010000005.1  155742543-155742654
            1254-1370           JAXUCZ010000005.1  155743955-155744071
            1371-3054           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3054
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..104
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..204
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            205..358
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    241..243
                     /gene="Hp1bp3"
                     /note="upstream in-frame stop codon"
     CDS             256..1668
                     /gene="Hp1bp3"
                     /note="isoform d is encoded by transcript variant 8"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform d"
                     /protein_id="NP_001423787.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MRLHLLHPGRQSSPRGSLRVERRKRASLLRKPRKKKDQSKEKEK
                     KVKKTIPAWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRK
                     YIIHKYPSLDLERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNR
                     KKGSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKN
                     ALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCST
                     TALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSP
                     GVLFPKKVSDGSEDEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRG
                     AKPARKVPAAQRGKVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKE
                     AKLPGKGKSAMKKKSFKTKK"
     misc_feature    469..723
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    469..723
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(490..492,526..528,622..624,664..666)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(490..492,526..528,622..624,664..666)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    607..642
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    607..642
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    796..978
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    796..978
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1024..1227
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1024..1227
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1366..1596
                     /gene="Hp1bp3"
                     /note="valyl-tRNA synthetase; Provisional; Region: valS;
                     PRK14900"
                     /db_xref="CDD:237855"
     misc_feature    <1366..1596
                     /gene="Hp1bp3"
                     /note="valyl-tRNA synthetase; Provisional; Region: valS;
                     PRK14900"
                     /db_xref="CDD:237855"
     exon            359..516
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..660
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..738
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            739..890
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..981
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1141
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1253
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1370
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..3054
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcggt gcccggcctg gaggacagcg gtgtcggagt cagcgatcgg tggtccgcag
       61 caacgctgag gggccgtacg ggacgcaggc gccggagctc agagaaagca gacgatagca
      121 ccatgcctat ccgtcgggct gtgaattcta ctcgggaaac tccgcccaaa agcaaacttg
      181 ctgaagggga agaagaaaaa ccagaaccag atgggagttc agaggagtct atctctacgg
      241 tagaagaacc agagaatgag actccacctg ctccatccag ggaggcagag cagcccaagg
      301 gggagcctga gagtggagag aaggaagaga gcaagtctgc tgaggaaacc aagaaagaag
      361 aaggatcagt ctaaagaaaa ggagaagaaa gtgaagaaaa ccatccctgc ctgggccact
      421 ctgtctgcca gccagctagc cagggcccag aaacaaaccc caatggcttc ctccccacgg
      481 ccaaagatgg atgcaatctt aactgaggcc attaaggcat gcttccagaa gagcggtgcc
      541 tccgtggttg ctatccggaa gtacatcatt cataagtacc cttctctgga tctggagaga
      601 aggggctatc tcctcaagca agcactgaaa agagagttaa acagaggagt catcaaacag
      661 gtaaaaggaa aaggtgcatc tggcagtttt gtcgtggtcc agaaatcaaa aacacctcag
      721 aaatccaaaa acagaaagaa gggctctgca gtggatccag aaccacaagt aaaactggaa
      781 gatgttctcc cattggcttt tacccgactc tgtgaaccta aggaagcctc ctacagtctc
      841 atcaggaaat acgtgtctca gtattaccct aagcttcgag tggacatcag gccccagttg
      901 ttgaagaatg ctctgcagag agcagtggag agaggccagt tagagcagat aactggcaag
      961 ggtgcttcgg ggacattcca gctgaagaaa tccggggaga aacccctgct tggtggaagc
     1021 ctgatggaat atgcaatctt gtctgccatt gctgccatga atgaacctaa gacctgctcc
     1081 accactgctc tgaagaagta tgtcctggag aaccacccag ggaccaattc taactaccaa
     1141 atgcatttgc tgaaaaaaac tctgcagaaa tgtgagaaga atgggtggct ggagcagatc
     1201 tctgggaagg ggttcagcgg caccttccag ctgtgcttcc cctattaccc cagcccagga
     1261 gttctgtttc caaagaaagt gtcagatggc tctgaggatg aggatgagga ggaggatgaa
     1321 gaggagtcat cagaggactc tgaggatgaa gagccgccac ccaagaggag cttacagaag
     1381 aaaacaccag ccaagcccca agggaagacg gcctccatga agcagagagg ggctaagcct
     1441 gcgcgtaaag tccctgctgc ccagagaggg aaggtgaggc cgctgcctaa gaaagctccg
     1501 cccaaggcta agacccctgc caggaaaggc agacccgcac cctcagccgt caagaagcct
     1561 agcgggagca cctccaaaaa gcctgtagcc aatgcacgaa aggaagcgaa actgcccggt
     1621 aagggcaaat ctgccatgaa gaagaagtct ttcaagacaa aaaagtaaat tttataggaa
     1681 aaagggtatc atgattgaat tcagaatctt attttataag gtcagtgtgc atttgtttta
     1741 gttataatgc ttttaaattt tacatttttc ttcccatacg aacactgtgg gaaggaatgt
     1801 aaacaaacca gtgtagacat ttgttggctt aggtgctgtt ctcagtgcct gcttcttcat
     1861 cattttaatt tctgccgtaa tcctggactt ggctgaactg tgtaactacc ctgctccctt
     1921 tgttcatctt aacccaaccc tcattctctt ctttttgtga tccaatttgg ggttttcttt
     1981 tcctcctcga agttaatcca aacagttgca aagatgcatt tgtagtgagt acctccaggt
     2041 ctggtgctga agccagacgg agcgggagca ctacagggac agcattgctt cctgcctggg
     2101 gacttgctga ttgaccctgg ctgtgaaatc actccactaa cctttctcca gcgtgggcca
     2161 gggacattat aactttggaa agaagcccca gtctgccatc catagattct gaagatctct
     2221 tctcctttgc tgtctgccca gttgccaagc acgccctgct gcccagagcg ttgttccctt
     2281 aacagcaagc gcacgtctgc gccacctgct ttctgactga aggggaagta caggaatatg
     2341 tggaatctga ttgcttatta ccaaaaatga cagaatattc ttgatcaaag gcctagatat
     2401 atttttaata tttggggcat gagcttcccc tgtttgagag ttcccattac tgaggtagaa
     2461 atgttaattt gctaaacata atttgctaaa atgaccagtt ttcagattca cctgtgcgtg
     2521 tgcccccact cgcaccccac cccattctct ccatagaacg tttgctgtca gctcggcggt
     2581 ctccatttcg aggtgtttat cagaagcgag gaggggagca aatgaagccg tgctgcccag
     2641 ccctcctcgt cttgtatttg tttaggttgt gaggttgtgt aaatagtagc ttcctacttg
     2701 agaactacag ctcctgctta tcattgatcc tttcctgtgg cacttaatat tttaattgtc
     2761 ttaagctttt gatgtacatc ctctggcccc ttacacgctg ccagaggaga aggtgtttga
     2821 gattcattcc acttgaagtg tctttcctgg gctccccaca gctgcagatg gctgggaagt
     2881 ggacttgagg aatgggctcg aattggtggt tcatgcctgt gaggacccat catgagtcat
     2941 cgggatttgt gttgcatgga aggcaatctt tcctgttgta aatcttcctt ttttatgtac
     3001 atatattttg aaaatatgaa taaacatgaa attttaaaag ctgctgaact acaa
//
LOCUS       NM_001436867            2796 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 6, mRNA.
ACCESSION   NM_001436867 XM_063287817
VERSION     NM_001436867.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2796)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2796)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2796)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2796)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2796)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287817.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.23594.1,
                                           SRR26643296.16622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-302             JAXUCZ010000005.1  159042847-159042943
            303-509             JAXUCZ010000005.1  159052105-159052311
            510-698             JAXUCZ010000005.1  159052950-159053138
            699-839             JAXUCZ010000005.1  159053664-159053804
            840-962             JAXUCZ010000005.1  159054043-159054165
            963-1204            JAXUCZ010000005.1  159054558-159054799
            1205-1347           JAXUCZ010000005.1  159054883-159055025
            1348-1648           JAXUCZ010000005.1  159055113-159055413
            1649-1736           JAXUCZ010000005.1  159055678-159055765
            1737-1853           JAXUCZ010000005.1  159055850-159055966
            1854-1974           JAXUCZ010000005.1  159056048-159056168
            1975-2105           JAXUCZ010000005.1  159056301-159056431
            2106-2315           JAXUCZ010000005.1  159056701-159056910
            2316-2405           JAXUCZ010000005.1  159057023-159057112
            2406-2796           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2796
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            206..302
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    260..262
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            303..509
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..2689
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform c is encoded by transcript variant 6; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform c"
                     /protein_id="NP_001423796.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEGGDKRAKEEKAAATVLSRLDQARSSSSAG
                     PGRELKEEWGGQAESASRGAEQTEKADAPREPPPVELKPDPTSSMAAAEAEALSESSE
                     QEMEVEPASKGEEGQEEEGPGPATVKEEGVHLENGEPPEENEESAGTDSGHELGMEGQ
                     NLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAF
                     SDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTT
                     SGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG
                     NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGAL
                     QRHVRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLAN
                     HIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHV
                     KTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADE
                     TEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQT
                     DADFYQQYGPGGAWPAGQMLQAGELVFRPRDGTEGQPTLAETPPTAPDCLPPAE"
     misc_feature    308..643
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    308..643
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(311..316,320..337,341..346,353..355,368..373,
                     416..418,422..424,431..439,452..454,530..535,542..553,
                     611..613)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(311..316,320..337,341..346,353..355,368..373,
                     416..418,422..424,431..439,452..454,530..535,542..553,
                     611..613)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(365..367,374..400,404..406,410..412,419..421,
                     479..484,488..493,497..499)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(365..367,374..400,404..406,410..412,419..421,
                     479..484,488..493,497..499)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1193..2188
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1193..2188
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1199..1261
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1199..1261
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1283..1345
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1283..1345
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1367..1429
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1367..1429
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1382..1384,1388..1390,1394..1396,1400..1405,
                     1412..1417,1424..1426,1466..1468,1472..1474,1484..1489,
                     1496..1501,1508..1510,1550..1552,1556..1558,1562..1564,
                     1568..1573,1580..1585,1592..1594)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1382..1384,1388..1390,1394..1396,1400..1405,
                     1412..1417,1424..1426,1466..1468,1472..1474,1484..1489,
                     1496..1501,1508..1510,1550..1552,1556..1558,1562..1564,
                     1568..1573,1580..1585,1592..1594)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1451..1513
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1451..1513
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1535..1597
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1535..1597
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1619..1681
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1619..1681
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1703..1765
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1703..1765
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1718..1720,1724..1726,1730..1732,1736..1741,
                     1748..1753,1760..1762,1802..1804,1808..1810,1820..1825,
                     1832..1837,1844..1846,1886..1888,1892..1894,1898..1900,
                     1904..1909,1916..1921,1928..1930)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1718..1720,1724..1726,1730..1732,1736..1741,
                     1748..1753,1760..1762,1802..1804,1808..1810,1820..1825,
                     1832..1837,1844..1846,1886..1888,1892..1894,1898..1900,
                     1904..1909,1916..1921,1928..1930)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1787..1849
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1787..1849
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1871..1933
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1871..1933
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1955..2017
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1955..2017
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2039..2101
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2039..2101
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2123..2182
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2123..2182
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            510..698
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            699..839
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            840..962
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1204
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1347
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1648
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1736
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1853
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1974
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2105
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2315
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2405
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2796
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagattct atcctcggag ccatctctcc aactggaaaa
      241 gaaagcctca gtttccatgt aacttctcag tcctttcttt ggtgctcgca ctttctgctt
      301 agccatggac ttcccccagc acagccagcg tgtcttggag cagctgaacc agcagcggca
      361 aatgggcctc ctctgtgact gcacctttgt ggtggacggc gttgacttca aagctcacaa
      421 ggcggtgctg gcagcctgca gcgagtactt caagatgctc tttgtggacc agaaggatgt
      481 ggtgcacctg gacatcagta atgcggcagg cctggggcag gtgctggagt tcatgtacac
      541 tgctaaactg caccttagcc ctgagaacgt ggatgatgtt ctggctgtgg ccagcttcct
      601 ccagatgcag gacattatca cagcctgcca caccctgaag tccctcgctg agcccaccag
      661 caccactggg gagagtgcag acgcctcggc cgaggaagga ggagacaagc gagccaaaga
      721 agagaaggct gccgccaccg tgctgagcag gctggaccaa gcaagaagca gttcatccgc
      781 aggcccaggc agagagctca aagaggagtg gggtggtcag gcagagagtg catccagggg
      841 cgcagaacag acggagaagg ccgacgcgcc ccgggagcct ccacctgtgg agctcaagcc
      901 ggaccccacg agcagcatgg ctgctgcaga agcggaagcc ttatcagaga gctcagagca
      961 agaaatggaa gtggaaccag ccagcaaagg agaagagggc caagaggaag agggcccagg
     1021 gcctgccacg gtcaaggaag agggcgttca cctggagaac ggggagcctc ctgaggagaa
     1081 tgaagagtct gcgggcacag actctgggca cgagcttggc atggagggcc agaacctgcg
     1141 ctcgggcacc tacggggacc gcactgagtc caaggcttat ggctccatca tccacaagtg
     1201 cgaggactgc gggaaggagt tcacgcacac agggaacttc aaacggcaca tccgcatcca
     1261 cacgggtgag aagccattct cctgtcggga gtgcagcaag gctttctcgg accccgcagc
     1321 ctgcaaggct cacgagaaga cacacagccc gttgaaaccc tatgggtgcg aggagtgcgg
     1381 caagagctac aggctcatca gcctgctgaa cctgcacaag aagaggcact cgggggaggc
     1441 gcgctaccgc tgcggggact gcggcaagct cttcaccact tccggcaacc tcaagcgcca
     1501 ccagctggta cacagtggcc agaaacccta ccagtgcgac tactgtggcc gttcattctc
     1561 cgaccccacg tccaagatgc gccacctgga gacccatgac actgacaagg agcacaagtg
     1621 ccctcactgt gacaagaagt tcaaccaggt ggggaacctg aaggcccact tgaagatcca
     1681 cattgctgac ggccctctca agtgccggga gtgcgggaag caattcacca cctcagggaa
     1741 cctcaagcgg cacctgcgga tccacagcgg ggagaagccg tatgtatgca cccactgtca
     1801 gcggcagttt gctgacccag gcgcgctgca gcggcacgta cggatccaca cgggtgagaa
     1861 gccgtgtcag tgcgtgatat gtggcaaggc cttcacccaa gccagctccc tcatcgccca
     1921 cgtacgccag cacacggggg agaagcccta tgtctgtgaa cgctgtggca agagatttgt
     1981 ccagtcaagc cagttggcca atcacattcg tcaccatgac aacatccgcc cacacaagtg
     2041 cagcgtgtgt agcaaggcct tcgtgaatgt gggggacctg tccaagcaca ttatcatcca
     2101 cactggagag aagccttact tatgtgacaa gtgtggccgt ggtttcaacc gggtagacaa
     2161 cctgcgttct cacgtaaaga ccgtgcatca gggcaaggcg ggcatcaaga tcctggagcc
     2221 agaagagggt ggtgaggtca gcgtggtcac tgtggacgac atggtcacac tggccactga
     2281 ggcactggca gcgacagcgg tcactcagct cacagtggta ccagtcgggg ccgcagtgac
     2341 agctgatgag acggaggttc tcaaagctga gatcagcaaa gctgtcaagc aagtgcagga
     2401 agaagatccc aacacccaca tcctgtatgc gtgtgattcc tgtggggaca agttcctgga
     2461 tgccaatagc ctggcccagc acgttcggat ccacacagca caggcactgg tcatgttcca
     2521 gacggatgcg gacttctacc agcagtacgg gccaggtggc gcgtggccag ccgggcagat
     2581 gctgcaggct ggagagctgg tcttccgtcc tagggatggg actgagggcc agcccacact
     2641 ggcagaaact ccacccacag ctcctgattg cctaccacct gccgagtaag caggtggccc
     2701 tctgactgtt tatttaagga tgggtggcac cccaggactc gaattccggt gctcctgccc
     2761 cattccctag agagaataaa tttgattatt ttctaa
//
LOCUS       NM_001436917            7154 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 5, mRNA.
ACCESSION   NM_001436917 XM_006237903
VERSION     NM_001436917.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7154)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7154)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7154)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7154)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7154)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7154)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006237903.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1254603.1,
                                           SRR26360172.1554205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000005.1  31992696-31992822
            128-265             JAXUCZ010000005.1  32078977-32079114
            266-507             JAXUCZ010000005.1  32081132-32081373
            508-597             JAXUCZ010000005.1  32085402-32085491
            598-779             JAXUCZ010000005.1  32089757-32089938
            780-1030            JAXUCZ010000005.1  32102023-32102273
            1031-1116           JAXUCZ010000005.1  32107640-32107725
            1117-1318           JAXUCZ010000005.1  32108284-32108485
            1319-1387           JAXUCZ010000005.1  32117199-32117267
            1388-1578           JAXUCZ010000005.1  32122846-32123036
            1579-7154           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7154
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..127
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1854
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform c is encoded by transcript variant 5;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform c"
                     /protein_id="NP_001423846.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MNTKRRCGGRAAGRLARSPPEDRTEKHSTMPDSPVDVKTQSRLT
                     PPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLA
                     NQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSK
                     LQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSP
                     VDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSY
                     QPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMID
                     HRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAE
                     DLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKR
                     QAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCW
                     NCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSS
                     GAGSPMDTPPAATPRSTTPGTPSTIETTPR"
     misc_feature    403..672
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    403..672
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1048..1248
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1048..1248
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1366..>1530
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1366..>1530
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1582..1692
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1582..1692
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            128..265
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..507
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..597
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..779
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1030
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1116
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1318
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1387
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1578
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..7154
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcacacac aatgtgccat ccccaccagc cctttacttc tgataagctc cgatgtgtgt
       61 ttaatgaata caaagcggcg gtgtgggggc cgcgcggccg gccgcctcgc gcgctcgccg
      121 ccggaagatc gtaccgagaa gcactccacg atgccagact cacctgtgga tgtgaagacg
      181 cagtctaggc tgactccccc agcaatgccg cctcctccga ccactcaagg agccccgaga
      241 accagttcgt ttacgccaac gacattaacg aatggcacca gccattcacc cacggccttg
      301 aatggcgccc cctcaccgcc taatggcttt agcaacgggc cttcctcttc ctcttcctct
      361 tctctggcta atcaacagct gcccccagcc tgtggtgcta gacaactgag caagctgaag
      421 cgatttctta ctaccctgca gcagtttggc aatgacattt caccagagat tggagaaaga
      481 gttcgcactc ttgtactagg actggtgaac tctactttga caattgaaga atttcattcc
      541 aaacttcaag aagctactaa cttcccactg agaccttttg tcatcccgtt tttgaaggcc
      601 aacctgcccc tgctacagcg tgaactcctc cactgcgcaa ggctagccaa acagaaccct
      661 gcccagtacc tcgctcagca cgaacagctg cttctggatg ccagcaccac ctcccctgtc
      721 gactcctcag agctgcttct cgatgtgaac gaaaacggga agaggcgaac tccagacaga
      781 accaaagaaa atggctttga cagagagcct ttgcactcag aacatccaag caagcgacca
      841 tgcactatta gcccaggcca gcggtacagt ccaaataatg gcttatccta ccagccaaat
      901 ggcctgcctc accccacccc acctccacct cagcattacc gtttggatga tatggccatt
      961 gcccaccact acagggactc ctatcgacac cccagccaca gggacctcag ggacagaaat
     1021 agacctatgg ggttacatgg cacacgtcaa gaagaaatga ttgaccacag actaacagac
     1081 agagaatggg cagaagagtg gaagcatctc gatcatctgt taaactgcat aatggacatg
     1141 gtagagaaga cgaggcgatc cctcactgta ctaagacgat gtcaggaagc agaccgggaa
     1201 gaactgaatt actggatccg gaggtacagt gatgctgagg acttgaaaaa gggcggcagc
     1261 ggtagcagca gccactccag gcaacagagc cccgtcaatc cggacccagt cgcattagat
     1321 gcacatcggg aattccttca caggcctgcg tctggatacg tgccagagga gatctggaag
     1381 aaagctgagg aggctgtgaa tgaggtgaag cgacaggcaa tgacggagct gcagaaagcc
     1441 gtgtctgaag ccgagaggaa agcccatgac atgatcacca cagagcgagc caaaatggaa
     1501 cgcacggtgg ctgaagccaa gcggcaggcc gcagaggatg ctctggcagt catcaaccag
     1561 caggaagact ccagtgagag ttgctggaac tgtggccgga aagcaagtga gacctgcagc
     1621 ggctgtaaca cggcccgata ctgtggctct ttttgccagc ataaagactg ggagaagcat
     1681 caccacatct gtggacagac cctgcaggcc ccacagcagg gagaaacgcc tgctgtcagc
     1741 tcctcagtca cgcccagcag tggggctggg agcccaatgg acacaccacc agcagccact
     1801 ccgaggtcta ccacccccgg aaccccctcc accatagaga cgacgcctcg ctagacctaa
     1861 actcagactg tcagaggaaa gacaccacaa ccaacacgaa agcaattcct catcctcaga
     1921 tgctcaaagt cccttttctg tttgtttgtt tatagatgaa ctatctatct tatttcagta
     1981 cttcggcaag agagaaccta actgtatctt tgaggcgata gtaaaacaca gaggccagta
     2041 acgggtcgta atgacttact gtggaaaaca aagatatctt ttctttagag aactgaaaag
     2101 agaggaaaga atataacgtg aaatgctaga tttgacctcc tccctgttat tttcaagtag
     2161 ctgggatttt aaactagatg acctcattaa ccaatgcttt accaaacagc aaaccaagag
     2221 attgctaatt gctgttgaaa gcaaaaatgc taatattaaa agtcacagtg ttctttatat
     2281 acaataatgg aaagaaaaaa aaaaaagagg caattcctca agggcacgag cgttggatac
     2341 agcagtagac attttaacaa gaagatgaat ggcgtctgtg ggttgctaac tgaactttga
     2401 agaccggctg caaaacgcac agatgtgcag cagattggaa ggagacacag atgttcgttt
     2461 tttttccccc gtttctgaaa aagaaataat aatatccagg tcaacagaat gaaaaatgaa
     2521 agatgatttc cagtggggtg tatgactaca gcagcaagaa aaaaaaaatt gccataatac
     2581 aaaggctcct ttttatatca cacacacaca cacacacaca cacacacaca cacacacaca
     2641 cacacacact cactctctct ctccctctct ctctctctta agagactcag cctgcagtta
     2701 attagcattc tggcagcttc caagtcagcc agctgcccta aataaccctt caacgtttct
     2761 tcacttttgc aaggttccac agagtaagac attgaatcta ttccagctta ttcattttat
     2821 atcgaaaaac caattttttt aaaaaaaaaa atggcggctt cagctccagc ccctttccaa
     2881 aatttttcaa ccccaccctg tttgggtttt taattaaaat ctagtagttc tcttggtatt
     2941 aaaacacttc tgtcctgtga ggttttccca atggtgtttt tcttgtaaat gtgttggaca
     3001 aatgtgaaga tgcgttgtag ttgatccata tgcccacatt tagtctcttt attcctagtt
     3061 ggtgagagaa accagtatct ttctatgctg cttttatatc tgtatgtatt agtgatattt
     3121 ctctagtagt taaaaaaaaa aaatgaaaag aaaagaaaaa aaaaaaccac actttttttg
     3181 gttgtcctca agaaaagaag aaaagaaaag aaaagaaaaa gctatctttt ggagctgcta
     3241 actcactctc ttataggatt tttttcctgg aaaccagcat gcttcatgga atgctagcac
     3301 atggatgttt ttaagaggga tgtacataaa tgtattttgc actgtcacaa tgactcccta
     3361 ggcatgcttt ttttttttca aaccaacttt ttaaatatgc tagagccatt tcaccaattt
     3421 tagctgtagc atagagtagt agtggaattt ttcttttatc ctttttttta tgaaaaaaaa
     3481 aattattagg gactttttaa aaaaaaataa aataagatat cctactttaa aaaaaaagga
     3541 cagtgcatgc atattgctgt aaggttgttt aagtatttct aattttacaa aaaaaaaatg
     3601 aaaaaaaaaa tcattagctc tccaaatgct gaggtgtaga cggacagctt tagccctgct
     3661 gagtgccagg ttatacagta ttcttacaaa agggaagtca gccaaagact gatctgatgg
     3721 accaaaatcg gaatttttga aaagcaccag taatcctttc caaatgatca gcaggttaaa
     3781 catgttcagt gtgactccat taacccttcg ttgtccaggg tccagaccag aactacttgt
     3841 tagttttgaa acacattatt agcccaggat gtggttgtgt gctttaagag tcggcagtgc
     3901 tgcaggctgt gtagacaacc aaagttgaaa ggctgggaag acacttttcc acatacacat
     3961 acaccaggca tttctttaca aaattgagta caatccatta gcttgtggga ggggggagcg
     4021 ggtaatgtag cccttggata cagttttaag tggttgtgtt ttaagttttc tgcatagatg
     4081 caatcctcac gggattgctt catgtctcgc aaatctaagg tttccttaaa ccatttcccc
     4141 tgtattttca tataccagtc ggttttgatt ttgtcccggt agtgttgtgt tcttttctct
     4201 tgtcgtcgtc gtcgttgttt tcaatggcct tttagtttag gaagttctga tgagcgaatc
     4261 aatgcatcta tctatctgca tgttggaagt ccatctgcca gcacacccgc taaggcaaag
     4321 agaagcgcat aaccaggctg cgaatgggtt ctattttacc atggtgctcc cagaatcctt
     4381 tgacctcatt ctgctttcta gtctgcttgt gacactggac agtcctttct tagagctatt
     4441 atatgttcta ggctacgaag ggttaaataa tcccaaaaaa aataacaaaa aaaaatgagg
     4501 tatgtcatac cctcgcgtct cgatctcaag aagctgtgat gtatgtggaa cagcactgtt
     4561 attctgaaca ctagtgtgta aaataaggat tagtacagta cgtctcattc cttttttaat
     4621 tcagggcacc ctgagtgaaa accaatacaa aaaaaaaaaa aaatccctaa ctctgagctc
     4681 tgtctctaat tcctcttcct ccttcccctc ttcctcctcc tcttcctcta ctcctgtttt
     4741 gctacattct cctcagtggc aaaaagtttc actctacctc tgacagcatg tatattgcac
     4801 cagtcgctaa cgaaaactgg tctagtcaaa ccaaatgggc acaaaagaac caggatacca
     4861 aaagttaagc tcatacagct gcgaaccata tcacttcttg gtaacaatgc agacctcata
     4921 aacctaaaaa aaaagagaaa gaaaagaaaa cttttgttac tttccttttt tgcttgtcac
     4981 ttatatacag gctatgtgag agtattcatt tgtaggtatt acacattaaa aaaaaaaagc
     5041 tatcttcatt ggatagaact gaatggtggt cgctgatagg aatagggcgt cctctatctc
     5101 ttatctctgt ctcttttctc tttctctttc tctgtcatga gactgtgtgt gacagggcta
     5161 cctgtctttt taatttgttt tctgaacttt ttttttttaa tgtgtaggtg catgtcttgg
     5221 ggatttaaaa atttcaaggc tggtttactt atgcaaagca tgcctatgtc tggaatactt
     5281 agggaaagaa agtgactcca tgttgtccga attcctcaag ggacagaaaa acaaattgga
     5341 gactgttgaa atgcagattt gaagtaattt tatttttaat tattttgggt tctgcgacat
     5401 tattgtgaaa aattaaagtc gttgtgcaat acttaattca gacacgtgcc acaagttaac
     5461 ggtagactaa cactgggggg cgggggctag gcatcacgct tttgtctgca tactcttgag
     5521 cttttaagtc tactatgtct gaactgtggt ttcttgttta tccttttttg ttttttcctt
     5581 agttggactg taatgtatgg tctgtcaacc tgtgaatctt taaagtatga ttcaggtatt
     5641 gttgtactct ttaccgtgta ataaaaatgc ttaaaaaaaa aagtcagtag tccgtctccc
     5701 ttatctttac tgtgtgcccg ccaaggctac cactcaggaa cctcattctt gaagggcagt
     5761 tcttcatgga gcatgcccag agtctagtca gctacagagt atgtctctaa cgtgttaatt
     5821 cgcccacgag tgatgaggga gaaggagaga acacagagga catttctgag gtcatagtag
     5881 tccaatatag aaggatactc caagtcctcc ataagaaagg atagcttatg ctaggggtca
     5941 ccgtctccag aaaggtccaa ttgccatctt tttaaactct ggcttgcagc atgtttcttt
     6001 cattctcagc tgcaggatgt acccactaag gcagatctct tcctccatct gtcctggatc
     6061 ctcaccgcct ttaattagaa gttgccagca tgttcacact tggttttgta catttgtaaa
     6121 tacacagtat gttgtgtcca tcttgtttct gagacccatg ttgtccattt aacacgcacc
     6181 agtatatttt ttttcatgca ctagctataa aaaataactt agactttgga gaacctattg
     6241 gtcatctacc atagaaactc agtcaatttt cacgtacttt acacaacaca ttttttaatg
     6301 actgtatata ctgcattgta gcagaatttc tgatttgctt ggaagattcc cgctatggcc
     6361 taaaactagc ttaaagggat caagtgaaat gcaagaactg aatctggaga gacagagaag
     6421 tcacatagac gctgtcgagt gggaggataa cctagggcct tctcttcagt ttcctttgta
     6481 cgccagctag gcccctatgc ctgtcctgag gcctggcttc tccaaatgat gttgagaaat
     6541 gcagcctatt ttacagagtg aggaagggag cggggaaggg agggagggag gagggagaaa
     6601 gagagagaga gagagagaga gagagagaga gagtttaaaa gcatagctag tgcgtatctt
     6661 attcctacaa aataaacagg ctgagtattt agttttgtag ttaatttttc ccctcactcc
     6721 aaagcctgac cagcgtggct caacttgctt ttcttatttg tacagataca ttttcttttt
     6781 cttttcaaag tggaacagac cagaaaccag aagacatgga ggacataact gagatgcctt
     6841 gaagtagccc ctttataagc tgtccttgaa aaacagctct gtgacctatt tgtatgactg
     6901 gattgctaga caaatgagta atgagtttag tttagaggaa gaatgtgaac aaaatcagct
     6961 tctgggtggt aagcaccatt ttttaaaaga atgtaattga tgtatttgat aatataaaaa
     7021 tgatgtttgc catgaaagaa cactaagtta tttccccaga ttggaagggg aagaaatgat
     7081 caaagaggtg cttttctgta tgggtattta tatctttatt tcaaggtgaa tgaataaagt
     7141 tgtacttgcc taaa
//
LOCUS       NM_001436862            2774 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 1, mRNA.
ACCESSION   NM_001436862 XM_039110079
VERSION     NM_001436862.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2774)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2774)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2774)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2774)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2774)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2774)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110079.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21641.1,
                                           SRR26643293.31324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-412             JAXUCZ010000005.1  159052105-159052311
            413-601             JAXUCZ010000005.1  159052950-159053138
            602-742             JAXUCZ010000005.1  159053664-159053804
            743-940             JAXUCZ010000005.1  159053968-159054165
            941-1182            JAXUCZ010000005.1  159054558-159054799
            1183-1325           JAXUCZ010000005.1  159054883-159055025
            1326-1626           JAXUCZ010000005.1  159055113-159055413
            1627-1714           JAXUCZ010000005.1  159055678-159055765
            1715-1831           JAXUCZ010000005.1  159055850-159055966
            1832-1952           JAXUCZ010000005.1  159056048-159056168
            1953-2083           JAXUCZ010000005.1  159056301-159056431
            2084-2293           JAXUCZ010000005.1  159056701-159056910
            2294-2383           JAXUCZ010000005.1  159057023-159057112
            2384-2774           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2774
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            206..412
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2667
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform a"
                     /protein_id="NP_001423791.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEGGDKRAKEEKAAATVLSRLDQARSSSSAG
                     PGRELKEEWGGQAESASRGFVPAMEETHLTSAQSPNPASHPSSGAEQTEKADAPREPP
                     PVELKPDPTSSMAAAEAEALSESSEQEMEVEPASKGEEGQEEEGPGPATVKEEGVHLE
                     NGEPPEENEESAGTDSGHELGMEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHT
                     GNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISL
                     LNLHKKRHSGEARYRCGDCGKLFTTSGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKM
                     RHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRH
                     LRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTGEKPCQCVICGKAFTQASSLIAHVR
                     QHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIH
                     TGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLA
                     TEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGD
                     KFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGAWPAGQMLQAGELVFRPRDGT
                     EGQPTLAETPPTAPDCLPPAE"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1171..2166
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1171..2166
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1177..1239
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1177..1239
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1261..1323
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1261..1323
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1345..1407
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1345..1407
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1360..1362,1366..1368,1372..1374,1378..1383,
                     1390..1395,1402..1404,1444..1446,1450..1452,1462..1467,
                     1474..1479,1486..1488,1528..1530,1534..1536,1540..1542,
                     1546..1551,1558..1563,1570..1572)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1360..1362,1366..1368,1372..1374,1378..1383,
                     1390..1395,1402..1404,1444..1446,1450..1452,1462..1467,
                     1474..1479,1486..1488,1528..1530,1534..1536,1540..1542,
                     1546..1551,1558..1563,1570..1572)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1429..1491
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1429..1491
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1513..1575
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1513..1575
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1597..1659
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1597..1659
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1681..1743
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1681..1743
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1696..1698,1702..1704,1708..1710,1714..1719,
                     1726..1731,1738..1740,1780..1782,1786..1788,1798..1803,
                     1810..1815,1822..1824,1864..1866,1870..1872,1876..1878,
                     1882..1887,1894..1899,1906..1908)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1696..1698,1702..1704,1708..1710,1714..1719,
                     1726..1731,1738..1740,1780..1782,1786..1788,1798..1803,
                     1810..1815,1822..1824,1864..1866,1870..1872,1876..1878,
                     1882..1887,1894..1899,1906..1908)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1765..1827
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1765..1827
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1849..1911
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1849..1911
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1933..1995
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1933..1995
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2017..2079
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2017..2079
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2101..2160
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2101..2160
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            413..601
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            602..742
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            743..940
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1182
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1325
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1626
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1714
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1831
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1952
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2083
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2293
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2383
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2774
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagccatg gacttccccc agcacagcca gcgtgtcttg
      241 gagcagctga accagcagcg gcaaatgggc ctcctctgtg actgcacctt tgtggtggac
      301 ggcgttgact tcaaagctca caaggcggtg ctggcagcct gcagcgagta cttcaagatg
      361 ctctttgtgg accagaagga tgtggtgcac ctggacatca gtaatgcggc aggcctgggg
      421 caggtgctgg agttcatgta cactgctaaa ctgcacctta gccctgagaa cgtggatgat
      481 gttctggctg tggccagctt cctccagatg caggacatta tcacagcctg ccacaccctg
      541 aagtccctcg ctgagcccac cagcaccact ggggagagtg cagacgcctc ggccgaggaa
      601 ggaggagaca agcgagccaa agaagagaag gctgccgcca ccgtgctgag caggctggac
      661 caagcaagaa gcagttcatc cgcaggccca ggcagagagc tcaaagagga gtggggtggt
      721 caggcagaga gtgcatccag ggggtttgtt ccagccatgg aagagaccca tttgacctct
      781 gcacagagtc ccaatccagc ctcccatccc tcctcaggcg cagaacagac ggagaaggcc
      841 gacgcgcccc gggagcctcc acctgtggag ctcaagccgg accccacgag cagcatggct
      901 gctgcagaag cggaagcctt atcagagagc tcagagcaag aaatggaagt ggaaccagcc
      961 agcaaaggag aagagggcca agaggaagag ggcccagggc ctgccacggt caaggaagag
     1021 ggcgttcacc tggagaacgg ggagcctcct gaggagaatg aagagtctgc gggcacagac
     1081 tctgggcacg agcttggcat ggagggccag aacctgcgct cgggcaccta cggggaccgc
     1141 actgagtcca aggcttatgg ctccatcatc cacaagtgcg aggactgcgg gaaggagttc
     1201 acgcacacag ggaacttcaa acggcacatc cgcatccaca cgggtgagaa gccattctcc
     1261 tgtcgggagt gcagcaaggc tttctcggac cccgcagcct gcaaggctca cgagaagaca
     1321 cacagcccgt tgaaacccta tgggtgcgag gagtgcggca agagctacag gctcatcagc
     1381 ctgctgaacc tgcacaagaa gaggcactcg ggggaggcgc gctaccgctg cggggactgc
     1441 ggcaagctct tcaccacttc cggcaacctc aagcgccacc agctggtaca cagtggccag
     1501 aaaccctacc agtgcgacta ctgtggccgt tcattctccg accccacgtc caagatgcgc
     1561 cacctggaga cccatgacac tgacaaggag cacaagtgcc ctcactgtga caagaagttc
     1621 aaccaggtgg ggaacctgaa ggcccacttg aagatccaca ttgctgacgg ccctctcaag
     1681 tgccgggagt gcgggaagca attcaccacc tcagggaacc tcaagcggca cctgcggatc
     1741 cacagcgggg agaagccgta tgtatgcacc cactgtcagc ggcagtttgc tgacccaggc
     1801 gcgctgcagc ggcacgtacg gatccacacg ggtgagaagc cgtgtcagtg cgtgatatgt
     1861 ggcaaggcct tcacccaagc cagctccctc atcgcccacg tacgccagca cacgggggag
     1921 aagccctatg tctgtgaacg ctgtggcaag agatttgtcc agtcaagcca gttggccaat
     1981 cacattcgtc accatgacaa catccgccca cacaagtgca gcgtgtgtag caaggccttc
     2041 gtgaatgtgg gggacctgtc caagcacatt atcatccaca ctggagagaa gccttactta
     2101 tgtgacaagt gtggccgtgg tttcaaccgg gtagacaacc tgcgttctca cgtaaagacc
     2161 gtgcatcagg gcaaggcggg catcaagatc ctggagccag aagagggtgg tgaggtcagc
     2221 gtggtcactg tggacgacat ggtcacactg gccactgagg cactggcagc gacagcggtc
     2281 actcagctca cagtggtacc agtcggggcc gcagtgacag ctgatgagac ggaggttctc
     2341 aaagctgaga tcagcaaagc tgtcaagcaa gtgcaggaag aagatcccaa cacccacatc
     2401 ctgtatgcgt gtgattcctg tggggacaag ttcctggatg ccaatagcct ggcccagcac
     2461 gttcggatcc acacagcaca ggcactggtc atgttccaga cggatgcgga cttctaccag
     2521 cagtacgggc caggtggcgc gtggccagcc gggcagatgc tgcaggctgg agagctggtc
     2581 ttccgtccta gggatgggac tgagggccag cccacactgg cagaaactcc acccacagct
     2641 cctgattgcc taccacctgc cgagtaagca ggtggccctc tgactgttta tttaaggatg
     2701 ggtggcaccc caggactcga attccggtgc tcctgcccca ttccctagag agaataaatt
     2761 tgattatttt ctaa
//
LOCUS       NM_001436887            2706 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 13, mRNA.
ACCESSION   NM_001436887 XM_063275499
VERSION     NM_001436887.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275499.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50078.1,
                                           SRR26643287.32330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-2706           JAXUCZ010000016.1  17514637-17515061
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2706
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2296
                     /gene="Eps15l1"
                     /note="isoform 13 is encoded by transcript variant 13;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 13"
                     /protein_id="NP_001423816.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFSNNSQELHPDPFQAED
                     PFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKKQT
                     KNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSAEG
                     FADFSQMSKGPAA"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1822
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1822
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2706
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 ggggcctgca gcctgaccag gatgatctgg aaacttccgt ggacaagctt tgaattaaga
     2341 ttctgccatt tgtgtataaa gacttgagag tgttcttagt agagtctcta ctcctccctg
     2401 ctctgcagcc tgacagcccg ccaggccttc ctgcatgaag ctcctagctc tacagaataa
     2461 ggatttgggg gcgggggagg gggggtctgg ttaggtctgt gaatctagag gggtgggggt
     2521 gggggctgga gagatggctc agtggttaag agcactgact gctcttccag aggtcctgag
     2581 ttcaattccc agcaaccaca tggtggctca caaccatctg taatgggacc tgatgccctc
     2641 ttctggtgtg tctgaagaca gccacaatgt atttatatat aataaataaa tctgttttta
     2701 aaaaga
//
LOCUS       NM_001436859            3248 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 9, mRNA.
ACCESSION   NM_001436859
VERSION     NM_001436859.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1139717.1,
                                           SRR26360194.2033830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050754, SAMN17050766
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000005.1  155719134-155719237
            105-298             JAXUCZ010000005.1  155724378-155724571
            299-398             JAXUCZ010000005.1  155724942-155725041
            399-552             JAXUCZ010000005.1  155726205-155726358
            553-710             JAXUCZ010000005.1  155728964-155729121
            711-854             JAXUCZ010000005.1  155732660-155732803
            855-932             JAXUCZ010000005.1  155734814-155734891
            933-1084            JAXUCZ010000005.1  155735359-155735510
            1085-1175           JAXUCZ010000005.1  155738870-155738960
            1176-1335           JAXUCZ010000005.1  155740995-155741154
            1336-1447           JAXUCZ010000005.1  155742543-155742654
            1448-1564           JAXUCZ010000005.1  155743955-155744071
            1565-3248           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3248
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..104
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..298
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            299..398
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..552
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    435..437
                     /gene="Hp1bp3"
                     /note="upstream in-frame stop codon"
     CDS             450..1862
                     /gene="Hp1bp3"
                     /note="isoform d is encoded by transcript variant 9"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform d"
                     /protein_id="NP_001423788.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MRLHLLHPGRQSSPRGSLRVERRKRASLLRKPRKKKDQSKEKEK
                     KVKKTIPAWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRK
                     YIIHKYPSLDLERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNR
                     KKGSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKN
                     ALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCST
                     TALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSP
                     GVLFPKKVSDGSEDEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRG
                     AKPARKVPAAQRGKVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKE
                     AKLPGKGKSAMKKKSFKTKK"
     misc_feature    663..917
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    663..917
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(684..686,720..722,816..818,858..860)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(684..686,720..722,816..818,858..860)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    801..836
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    801..836
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    990..1172
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    990..1172
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1218..1421
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1218..1421
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1560..1790
                     /gene="Hp1bp3"
                     /note="valyl-tRNA synthetase; Provisional; Region: valS;
                     PRK14900"
                     /db_xref="CDD:237855"
     misc_feature    <1560..1790
                     /gene="Hp1bp3"
                     /note="valyl-tRNA synthetase; Provisional; Region: valS;
                     PRK14900"
                     /db_xref="CDD:237855"
     exon            553..710
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..854
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..932
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1084
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1175
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1335
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1447
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1564
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..3248
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcggt gcccggcctg gaggacagcg gtgtcggagt cagcgatcgg tggtccgcag
       61 caacgctgag gggccgtacg ggacgcaggc gccggagctc agaggttgac tcttcaccac
      121 actgaagcca ttaggaaacc cctgtgatta acagcagagg cttcagagtc tcaccagtat
      181 tcaggcctag actttatttt aaatggcaac tgatatgtct caaggtgaac tcatccatcc
      241 taaggcactc ccacttatag taggagctca gctgatccac gcggacaagt taggtgagaa
      301 agcagacgat agcaccatgc ctatccgtcg ggctgtgaat tctactcggg aaactccgcc
      361 caaaagcaaa cttgctgaag gggaagaaga aaaaccagaa ccagatggga gttcagagga
      421 gtctatctct acggtagaag aaccagagaa tgagactcca cctgctccat ccagggaggc
      481 agagcagccc aagggggagc ctgagagtgg agagaaggaa gagagcaagt ctgctgagga
      541 aaccaagaaa gaagaaggat cagtctaaag aaaaggagaa gaaagtgaag aaaaccatcc
      601 ctgcctgggc cactctgtct gccagccagc tagccagggc ccagaaacaa accccaatgg
      661 cttcctcccc acggccaaag atggatgcaa tcttaactga ggccattaag gcatgcttcc
      721 agaagagcgg tgcctccgtg gttgctatcc ggaagtacat cattcataag tacccttctc
      781 tggatctgga gagaaggggc tatctcctca agcaagcact gaaaagagag ttaaacagag
      841 gagtcatcaa acaggtaaaa ggaaaaggtg catctggcag ttttgtcgtg gtccagaaat
      901 caaaaacacc tcagaaatcc aaaaacagaa agaagggctc tgcagtggat ccagaaccac
      961 aagtaaaact ggaagatgtt ctcccattgg cttttacccg actctgtgaa cctaaggaag
     1021 cctcctacag tctcatcagg aaatacgtgt ctcagtatta ccctaagctt cgagtggaca
     1081 tcaggcccca gttgttgaag aatgctctgc agagagcagt ggagagaggc cagttagagc
     1141 agataactgg caagggtgct tcggggacat tccagctgaa gaaatccggg gagaaacccc
     1201 tgcttggtgg aagcctgatg gaatatgcaa tcttgtctgc cattgctgcc atgaatgaac
     1261 ctaagacctg ctccaccact gctctgaaga agtatgtcct ggagaaccac ccagggacca
     1321 attctaacta ccaaatgcat ttgctgaaaa aaactctgca gaaatgtgag aagaatgggt
     1381 ggctggagca gatctctggg aaggggttca gcggcacctt ccagctgtgc ttcccctatt
     1441 accccagccc aggagttctg tttccaaaga aagtgtcaga tggctctgag gatgaggatg
     1501 aggaggagga tgaagaggag tcatcagagg actctgagga tgaagagccg ccacccaaga
     1561 ggagcttaca gaagaaaaca ccagccaagc cccaagggaa gacggcctcc atgaagcaga
     1621 gaggggctaa gcctgcgcgt aaagtccctg ctgcccagag agggaaggtg aggccgctgc
     1681 ctaagaaagc tccgcccaag gctaagaccc ctgccaggaa aggcagaccc gcaccctcag
     1741 ccgtcaagaa gcctagcggg agcacctcca aaaagcctgt agccaatgca cgaaaggaag
     1801 cgaaactgcc cggtaagggc aaatctgcca tgaagaagaa gtctttcaag acaaaaaagt
     1861 aaattttata ggaaaaaggg tatcatgatt gaattcagaa tcttatttta taaggtcagt
     1921 gtgcatttgt tttagttata atgcttttaa attttacatt tttcttccca tacgaacact
     1981 gtgggaagga atgtaaacaa accagtgtag acatttgttg gcttaggtgc tgttctcagt
     2041 gcctgcttct tcatcatttt aatttctgcc gtaatcctgg acttggctga actgtgtaac
     2101 taccctgctc cctttgttca tcttaaccca accctcattc tcttcttttt gtgatccaat
     2161 ttggggtttt cttttcctcc tcgaagttaa tccaaacagt tgcaaagatg catttgtagt
     2221 gagtacctcc aggtctggtg ctgaagccag acggagcggg agcactacag ggacagcatt
     2281 gcttcctgcc tggggacttg ctgattgacc ctggctgtga aatcactcca ctaacctttc
     2341 tccagcgtgg gccagggaca ttataacttt ggaaagaagc cccagtctgc catccataga
     2401 ttctgaagat ctcttctcct ttgctgtctg cccagttgcc aagcacgccc tgctgcccag
     2461 agcgttgttc ccttaacagc aagcgcacgt ctgcgccacc tgctttctga ctgaagggga
     2521 agtacaggaa tatgtggaat ctgattgctt attaccaaaa atgacagaat attcttgatc
     2581 aaaggcctag atatattttt aatatttggg gcatgagctt cccctgtttg agagttccca
     2641 ttactgaggt agaaatgtta atttgctaaa cataatttgc taaaatgacc agttttcaga
     2701 ttcacctgtg cgtgtgcccc cactcgcacc ccaccccatt ctctccatag aacgtttgct
     2761 gtcagctcgg cggtctccat ttcgaggtgt ttatcagaag cgaggagggg agcaaatgaa
     2821 gccgtgctgc ccagccctcc tcgtcttgta tttgtttagg ttgtgaggtt gtgtaaatag
     2881 tagcttccta cttgagaact acagctcctg cttatcattg atcctttcct gtggcactta
     2941 atattttaat tgtcttaagc ttttgatgta catcctctgg ccccttacac gctgccagag
     3001 gagaaggtgt ttgagattca ttccacttga agtgtctttc ctgggctccc cacagctgca
     3061 gatggctggg aagtggactt gaggaatggg ctcgaattgg tggttcatgc ctgtgaggac
     3121 ccatcatgag tcatcgggat ttgtgttgca tggaaggcaa tctttcctgt tgtaaatctt
     3181 ccttttttat gtacatatat tttgaaaata tgaataaaca tgaaatttta aaagctgctg
     3241 aactacaa
//
LOCUS       NM_001436866            2823 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 5, mRNA.
ACCESSION   NM_001436866 XM_063287816
VERSION     NM_001436866.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2823)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2823)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2823)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2823)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2823)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287816.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29983.1,
                                           SRR26360181.1164224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-329             JAXUCZ010000005.1  159039733-159039856
            330-536             JAXUCZ010000005.1  159052105-159052311
            537-725             JAXUCZ010000005.1  159052950-159053138
            726-866             JAXUCZ010000005.1  159053664-159053804
            867-989             JAXUCZ010000005.1  159054043-159054165
            990-1231            JAXUCZ010000005.1  159054558-159054799
            1232-1374           JAXUCZ010000005.1  159054883-159055025
            1375-1675           JAXUCZ010000005.1  159055113-159055413
            1676-1763           JAXUCZ010000005.1  159055678-159055765
            1764-1880           JAXUCZ010000005.1  159055850-159055966
            1881-2001           JAXUCZ010000005.1  159056048-159056168
            2002-2132           JAXUCZ010000005.1  159056301-159056431
            2133-2342           JAXUCZ010000005.1  159056701-159056910
            2343-2432           JAXUCZ010000005.1  159057023-159057112
            2433-2823           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2823
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            206..329
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    323..325
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            330..536
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..2716
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform c is encoded by transcript variant 5; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform c"
                     /protein_id="NP_001423795.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEGGDKRAKEEKAAATVLSRLDQARSSSSAG
                     PGRELKEEWGGQAESASRGAEQTEKADAPREPPPVELKPDPTSSMAAAEAEALSESSE
                     QEMEVEPASKGEEGQEEEGPGPATVKEEGVHLENGEPPEENEESAGTDSGHELGMEGQ
                     NLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAF
                     SDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTT
                     SGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG
                     NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGAL
                     QRHVRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLAN
                     HIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHV
                     KTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADE
                     TEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQT
                     DADFYQQYGPGGAWPAGQMLQAGELVFRPRDGTEGQPTLAETPPTAPDCLPPAE"
     misc_feature    335..670
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    335..670
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(338..343,347..364,368..373,380..382,395..400,
                     443..445,449..451,458..466,479..481,557..562,569..580,
                     638..640)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(338..343,347..364,368..373,380..382,395..400,
                     443..445,449..451,458..466,479..481,557..562,569..580,
                     638..640)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(392..394,401..427,431..433,437..439,446..448,
                     506..511,515..520,524..526)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(392..394,401..427,431..433,437..439,446..448,
                     506..511,515..520,524..526)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1220..2215
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1220..2215
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1226..1288
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1226..1288
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1310..1372
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1310..1372
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1394..1456
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1394..1456
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1409..1411,1415..1417,1421..1423,1427..1432,
                     1439..1444,1451..1453,1493..1495,1499..1501,1511..1516,
                     1523..1528,1535..1537,1577..1579,1583..1585,1589..1591,
                     1595..1600,1607..1612,1619..1621)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1409..1411,1415..1417,1421..1423,1427..1432,
                     1439..1444,1451..1453,1493..1495,1499..1501,1511..1516,
                     1523..1528,1535..1537,1577..1579,1583..1585,1589..1591,
                     1595..1600,1607..1612,1619..1621)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1478..1540
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1478..1540
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1562..1624
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1562..1624
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1646..1708
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1730..1792
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1730..1792
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1745..1747,1751..1753,1757..1759,1763..1768,
                     1775..1780,1787..1789,1829..1831,1835..1837,1847..1852,
                     1859..1864,1871..1873,1913..1915,1919..1921,1925..1927,
                     1931..1936,1943..1948,1955..1957)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1745..1747,1751..1753,1757..1759,1763..1768,
                     1775..1780,1787..1789,1829..1831,1835..1837,1847..1852,
                     1859..1864,1871..1873,1913..1915,1919..1921,1925..1927,
                     1931..1936,1943..1948,1955..1957)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1814..1876
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1814..1876
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1898..1960
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1898..1960
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1982..2044
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1982..2044
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2066..2128
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2066..2128
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2150..2209
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2150..2209
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            537..725
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            726..866
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            867..989
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1231
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1374
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1675
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1763
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1880
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2001
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2132
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2342
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2432
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2823
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagtgtct ctacccatgg ctgtctagtc cttcccggct
      241 tcacaatcac agaggtctgt tggtgcttcc caggggctgg gattaaaggc atacgtcacc
      301 acactcggct tttatcttat tttaattagc catggacttc ccccagcaca gccagcgtgt
      361 cttggagcag ctgaaccagc agcggcaaat gggcctcctc tgtgactgca cctttgtggt
      421 ggacggcgtt gacttcaaag ctcacaaggc ggtgctggca gcctgcagcg agtacttcaa
      481 gatgctcttt gtggaccaga aggatgtggt gcacctggac atcagtaatg cggcaggcct
      541 ggggcaggtg ctggagttca tgtacactgc taaactgcac cttagccctg agaacgtgga
      601 tgatgttctg gctgtggcca gcttcctcca gatgcaggac attatcacag cctgccacac
      661 cctgaagtcc ctcgctgagc ccaccagcac cactggggag agtgcagacg cctcggccga
      721 ggaaggagga gacaagcgag ccaaagaaga gaaggctgcc gccaccgtgc tgagcaggct
      781 ggaccaagca agaagcagtt catccgcagg cccaggcaga gagctcaaag aggagtgggg
      841 tggtcaggca gagagtgcat ccaggggcgc agaacagacg gagaaggccg acgcgccccg
      901 ggagcctcca cctgtggagc tcaagccgga ccccacgagc agcatggctg ctgcagaagc
      961 ggaagcctta tcagagagct cagagcaaga aatggaagtg gaaccagcca gcaaaggaga
     1021 agagggccaa gaggaagagg gcccagggcc tgccacggtc aaggaagagg gcgttcacct
     1081 ggagaacggg gagcctcctg aggagaatga agagtctgcg ggcacagact ctgggcacga
     1141 gcttggcatg gagggccaga acctgcgctc gggcacctac ggggaccgca ctgagtccaa
     1201 ggcttatggc tccatcatcc acaagtgcga ggactgcggg aaggagttca cgcacacagg
     1261 gaacttcaaa cggcacatcc gcatccacac gggtgagaag ccattctcct gtcgggagtg
     1321 cagcaaggct ttctcggacc ccgcagcctg caaggctcac gagaagacac acagcccgtt
     1381 gaaaccctat gggtgcgagg agtgcggcaa gagctacagg ctcatcagcc tgctgaacct
     1441 gcacaagaag aggcactcgg gggaggcgcg ctaccgctgc ggggactgcg gcaagctctt
     1501 caccacttcc ggcaacctca agcgccacca gctggtacac agtggccaga aaccctacca
     1561 gtgcgactac tgtggccgtt cattctccga ccccacgtcc aagatgcgcc acctggagac
     1621 ccatgacact gacaaggagc acaagtgccc tcactgtgac aagaagttca accaggtggg
     1681 gaacctgaag gcccacttga agatccacat tgctgacggc cctctcaagt gccgggagtg
     1741 cgggaagcaa ttcaccacct cagggaacct caagcggcac ctgcggatcc acagcgggga
     1801 gaagccgtat gtatgcaccc actgtcagcg gcagtttgct gacccaggcg cgctgcagcg
     1861 gcacgtacgg atccacacgg gtgagaagcc gtgtcagtgc gtgatatgtg gcaaggcctt
     1921 cacccaagcc agctccctca tcgcccacgt acgccagcac acgggggaga agccctatgt
     1981 ctgtgaacgc tgtggcaaga gatttgtcca gtcaagccag ttggccaatc acattcgtca
     2041 ccatgacaac atccgcccac acaagtgcag cgtgtgtagc aaggccttcg tgaatgtggg
     2101 ggacctgtcc aagcacatta tcatccacac tggagagaag ccttacttat gtgacaagtg
     2161 tggccgtggt ttcaaccggg tagacaacct gcgttctcac gtaaagaccg tgcatcaggg
     2221 caaggcgggc atcaagatcc tggagccaga agagggtggt gaggtcagcg tggtcactgt
     2281 ggacgacatg gtcacactgg ccactgaggc actggcagcg acagcggtca ctcagctcac
     2341 agtggtacca gtcggggccg cagtgacagc tgatgagacg gaggttctca aagctgagat
     2401 cagcaaagct gtcaagcaag tgcaggaaga agatcccaac acccacatcc tgtatgcgtg
     2461 tgattcctgt ggggacaagt tcctggatgc caatagcctg gcccagcacg ttcggatcca
     2521 cacagcacag gcactggtca tgttccagac ggatgcggac ttctaccagc agtacgggcc
     2581 aggtggcgcg tggccagccg ggcagatgct gcaggctgga gagctggtct tccgtcctag
     2641 ggatgggact gagggccagc ccacactggc agaaactcca cccacagctc ctgattgcct
     2701 accacctgcc gagtaagcag gtggccctct gactgtttat ttaaggatgg gtggcacccc
     2761 aggactcgaa ttccggtgct cctgccccat tccctagaga gaataaattt gattattttc
     2821 taa
//
LOCUS       NM_001436882            3164 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 8, mRNA.
ACCESSION   NM_001436882 XM_017600170
VERSION     NM_001436882.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017600170.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1029982.1,
                                           SRR26360190.2964261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1831           JAXUCZ010000016.1  17498298-17498468
            1832-1955           JAXUCZ010000016.1  17503674-17503797
            1956-2006           JAXUCZ010000016.1  17504488-17504538
            2007-2143           JAXUCZ010000016.1  17505392-17505528
            2144-2204           JAXUCZ010000016.1  17508313-17508373
            2205-2287           JAXUCZ010000016.1  17509056-17509138
            2288-3164           JAXUCZ010000016.1  17514185-17515061
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3164
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2389
                     /gene="Eps15l1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     epidermal growth factor receptor substrate 15-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate
                     15-like 1 isoform 8"
                     /protein_id="NP_001423811.1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
                     /translation="MAAPLLPLSQQIPSGNPLYESYYKQVDPAYTGRVGASEAALFLK
                     KSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLGLTMPPPK
                     FHDTSSPLMATQSSAEAHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSKLP
                     LDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVLPPPLIPPSKRKKTV
                     FAGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSVKQTQPPVAWVVPVADK
                     MRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFA
                     LAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPIPDSSSALGSGEFTGVKELDDISQE
                     IAQLQREKYSLEQDIREKEEAIRQKASEVQELQNDLDRETSSLQELEAQKQDAQDRLD
                     EMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQEDDLNRAKSELNRL
                     QQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRSLEQYDQ
                     VPDGVSGTSLPDLATLNEGILLAERGGFGAMVKDDPFKNKALLFSNNSQELHPDPFQA
                     EDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPFKESDPFHSSTSDDFFKK
                     QTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLDPFGSSSFSSA
                     EGFADFSQMSKSPRQEELRVCRHKLQKEVGSPTCLTIQKCPLSL"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    89..289
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; found in proteins implicated
                     in endocytosis, vesicle transport, and signal
                     transduction. The alignment contains a pair of EF-hand
                     motifs, typically one of them is canonical and binds to
                     Ca2+, while the other may not bind to Ca2+. A...; Region:
                     EH; cd00052"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(107..115,134..148)
                     /gene="Eps15l1"
                     /note="pseudo EF-hand loop [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(161..163,191..193,203..205)
                     /gene="Eps15l1"
                     /note="peptide binding pocket [active]"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    order(215..217,221..223,227..229,248..250)
                     /gene="Eps15l1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238009"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    395..676
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    836..1126
                     /gene="Eps15l1"
                     /note="Eps15 homology domain; Region: EH; smart00027"
                     /db_xref="CDD:197477"
     misc_feature    1175..>1828
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     misc_feature    1175..>1828
                     /gene="Eps15l1"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]; Region: COG4372"
                     /db_xref="CDD:443500"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1831
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1955
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2006
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2143
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2204
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2287
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..3164
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggtaaa ggatgatcct ttcaaaaaca aagccttgtt
     1861 gtttagcaac aactctcaag agctgcatcc agaccccttc caggcagagg accccttcaa
     1921 gtctgaccca tttaaaggag ctgatccctt caaaggtgac cctttccaga gtgatccctt
     1981 ctcagagcag cagacagcag ttacagaccc atttggaggg gaccctttca aagaaagtga
     2041 cccattccat agctcaacca gtgatgactt cttcaagaaa cagacaaaga atgacccgtt
     2101 tacctcagac cccttcacaa agaacccttc cttaccttca aagctcgacc cattcgagtc
     2161 cagtgatccc ttctcatcct ccagcatctc ctcgaaaggt tcagatccct tcggaacact
     2221 agaccccttt ggaagcagct ccttcagcag tgccgagggt ttcgctgact tcagtcagat
     2281 gtccaagtcc ccaaggcagg aggagttgag agtctgtaga cataagcttc agaaagaggt
     2341 gggatcgccc acatgcctca cgatacagaa gtgtcctctt agcctgtgag gacccatctt
     2401 gggagccctc ccccagtgga tgcctgaccc tgtgttcact gctccctttg cacttctgga
     2461 aaagcatgac ttgtaaacaa ggaacagttg gcaagtggaa gagtcacagc atgctgcagt
     2521 aaaagttatt tcagactcag gaactgtttt tctggaacct tttcctcttc atgttctcag
     2581 catgatggac catgacatga caaggtgggg cagctgtagt cactgtgcca tctctgctgg
     2641 tctgtccgtc acagtacaga tggggaagca agcaaggcac aggcagttgg actgggattt
     2701 cagcccaggt tgagtaaccc agctcacctc tgaccacagg ggcctgcagc ctgaccagga
     2761 tgatctggaa acttccgtgg acaagctttg aattaagatt ctgccatttg tgtataaaga
     2821 cttgagagtg ttcttagtag agtctctact cctccctgct ctgcagcctg acagcccgcc
     2881 aggccttcct gcatgaagct cctagctcta cagaataagg atttgggggc gggggagggg
     2941 gggtctggtt aggtctgtga atctagaggg gtgggggtgg gggctggaga gatggctcag
     3001 tggttaagag cactgactgc tcttccagag gtcctgagtt caattcccag caaccacatg
     3061 gtggctcaca accatctgta atgggacctg atgccctctt ctggtgtgtc tgaagacagc
     3121 cacaatgtat ttatatataa taaataaatc tgtttttaaa aaga
//
LOCUS       NM_017184                902 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus troponin I1, slow skeletal type (Tnni1),
            transcript variant 2, mRNA.
ACCESSION   NM_017184
VERSION     NM_017184.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 902)
  AUTHORS   Lin,Y.H., Schmidt,W., Fritz,K.S., Jeong,M.Y., Cammarato,A.,
            Foster,D.B., Biesiadecki,B.J., McKinsey,T.A. and Woulfe,K.C.
  TITLE     Site-specific acetyl-mimetic modification of cardiac troponin I
            modulates myofilament relaxation and calcium sensitivity
  JOURNAL   J Mol Cell Cardiol 139, 135-147 (2020)
   PUBMED   31981571
  REMARK    GeneRIF: Site-specific acetyl-mimetic modification of cardiac
            troponin I modulates myofilament relaxation and calcium
            sensitivity.
REFERENCE   2  (bases 1 to 902)
  AUTHORS   Liu,W., Kuang,H., Xia,Y., Pope,Z.C., Wang,Z., Tang,C. and Yin,D.
  TITLE     Regular aerobic exercise-ameliorated troponin I carbonylation to
            mitigate aged rat soleus muscle functional recession
  JOURNAL   Exp Physiol 104 (5), 715-728 (2019)
   PUBMED   30820991
  REMARK    GeneRIF: regular aerobic exercise appeared to have antioxidant
            effects in the muscle that reduced TNNI1 slow carbonylation and
            promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and
            TNNI1 expression for skeletal muscle contraction regulation
REFERENCE   3  (bases 1 to 902)
  AUTHORS   Potluri,P.R., Chamoun,J., Cooke,J.A., Badr,M., Guse,J.A., Rayes,R.,
            Cordina,N.M., McCamey,D., Fajer,P.G. and Brown,L.J.
  TITLE     The concerted movement of the switch region of Troponin I in
            cardiac muscle thin filaments as tracked by conventional and pulsed
            (DEER) EPR
  JOURNAL   J Struct Biol 200 (3), 376-387 (2017)
   PUBMED   28864299
  REMARK    GeneRIF: Troponin I interaction with calcium and Troponin C in
            cardiac muscle
REFERENCE   4  (bases 1 to 902)
  AUTHORS   Cheng,Y., Rao,V., Tu,A.Y., Lindert,S., Wang,D., Oxenford,L.,
            McCulloch,A.D., McCammon,J.A. and Regnier,M.
  TITLE     Troponin I Mutations R146G and R21C Alter Cardiac Troponin
            Function, Contractile Properties, and Modulation by Protein Kinase
            A (PKA)-mediated Phosphorylation
  JOURNAL   J Biol Chem 290 (46), 27749-27766 (2015)
   PUBMED   26391394
  REMARK    GeneRIF: these results suggest that cTnI(R146G) and cTnI(R21C)
            blunt PKA modulation of activation and relaxation kinetics by
            prohibiting cardiac-specific N-terminal interaction with the cTnI
            inhibitory peptide.
REFERENCE   5  (bases 1 to 902)
  AUTHORS   Christopher,B., Pizarro,G.O., Nicholson,B., Yuen,S., Hoit,B.D. and
            Ogut,O.
  TITLE     Reduced force production during low blood flow to the heart
            correlates with altered troponin I phosphorylation
  JOURNAL   J Muscle Res Cell Motil 30 (3-4), 111-123 (2009)
   PUBMED   19507043
  REMARK    GeneRIF: These findings suggest that altered TnI function, due to
            changes in the distribution of phosphorylated sites, is an early
            contributor to reduced contractility of the heart.
REFERENCE   6  (bases 1 to 902)
  AUTHORS   Takimoto,E., Soergel,D.G., Janssen,P.M., Stull,L.B., Kass,D.A. and
            Murphy,A.M.
  TITLE     Frequency- and afterload-dependent cardiac modulation in vivo by
            troponin I with constitutively active protein kinase A
            phosphorylation sites
  JOURNAL   Circ Res 94 (4), 496-504 (2004)
   PUBMED   14726477
  REMARK    GeneRIF: A novel role is described for cardiac TnI PKA
            phosphorylation in the rate-dependent enhancement of systolic &
            diastolic function in vivo & afterload sensitivity of relaxation.
            This has implications for cardiac failure.
REFERENCE   7  (bases 1 to 902)
  AUTHORS   Westfall,M.V. and Borton,A.R.
  TITLE     Role of troponin I phosphorylation in protein kinase C-mediated
            enhanced contractile performance of rat myocytes
  JOURNAL   J Biol Chem 278 (36), 33694-33700 (2003)
   PUBMED   12815045
  REMARK    GeneRIF: troponin I phosphorylation has a role in protein kinase
            C-mediated enhanced contractile performance of myocytes
REFERENCE   8  (bases 1 to 902)
  AUTHORS   Metzger,J.M., Michele,D.E., Rust,E.M., Borton,A.R. and
            Westfall,M.V.
  TITLE     Sarcomere thin filament regulatory isoforms. Evidence of a dominant
            effect of slow skeletal troponin I on cardiac contraction
  JOURNAL   J Biol Chem 278 (15), 13118-13123 (2003)
   PUBMED   12551900
REFERENCE   9  (bases 1 to 902)
  AUTHORS   Huang,X., Pi,Y., Lee,K.J., Henkel,A.S., Gregg,R.G., Powers,P.A. and
            Walker,J.W.
  TITLE     Cardiac troponin I gene knockout: a mouse model of myocardial
            troponin I deficiency
  JOURNAL   Circ Res 84 (1), 1-8 (1999)
   PUBMED   9915769
REFERENCE   10 (bases 1 to 902)
  AUTHORS   Koppe,R.I., Hallauer,P.L., Karpati,G. and Hastings,K.E.
  TITLE     cDNA clone and expression analysis of rodent fast and slow skeletal
            muscle troponin I mRNAs
  JOURNAL   J Biol Chem 264 (24), 14327-14333 (1989)
   PUBMED   2760067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 24, 2025 this sequence version replaced NM_017184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217411.1, CR756258.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000013.1  49780993-49781048
            57-104              JAXUCZ010000013.1  49781506-49781553
            105-134             JAXUCZ010000013.1  49784766-49784795
            135-138             JAXUCZ010000013.1  49785490-49785493
            139-180             JAXUCZ010000013.1  49787394-49787435
            181-312             JAXUCZ010000013.1  49787901-49788032
            313-402             JAXUCZ010000013.1  49789943-49790032
            403-579             JAXUCZ010000013.1  49791065-49791241
            580-902             JAXUCZ010000013.1  49792024-49792346
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..902
                     /gene="Tnni1"
                     /note="troponin I1, slow skeletal type"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
     exon            1..56
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Tnni1"
                     /note="upstream in-frame stop codon"
     exon            57..104
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..134
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..687
                     /gene="Tnni1"
                     /note="troponin I, skeletal, slow 1; troponin I type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin I, slow skeletal muscle"
                     /protein_id="NP_058880.2"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
                     /translation="MPEVERKSKITASRKLMLKSLMLAKAKECWEQEHEEREAEKVRY
                     LSERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVL
                     DLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGD
                     WRKNVEAMSGMEGRKKMFDAAKSPTSQ"
     misc_feature    127..267
                     /gene="Tnni1"
                     /note="propagated from UniProtKB/Swiss-Prot (P13413.2);
                     Region: Involved in binding TNC"
     misc_feature    127..129
                     /gene="Tnni1"
                     /note="N-acetylproline.
                     /evidence=ECO:0000250|UniProtKB:P02645; propagated from
                     UniProtKB/Swiss-Prot (P13413.2); acetylation site"
     misc_feature    166..561
                     /gene="Tnni1"
                     /note="Region: Troponin; pfam00992"
                     /db_xref="CDD:460018"
     misc_feature    166..561
                     /gene="Tnni1"
                     /note="Region: Troponin; pfam00992"
                     /db_xref="CDD:460018"
     misc_feature    295..297
                     /gene="Tnni1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P13413.2); phosphorylation site"
     misc_feature    412..477
                     /gene="Tnni1"
                     /note="propagated from UniProtKB/Swiss-Prot (P13413.2);
                     Region: Involved in binding TNC and actin"
     exon            135..138
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..180
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..312
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..402
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..579
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..902
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctgccgt ctgtggtgag gctcgggcca gcctagctcc acgaggacta aactaggtgc
       61 tttgagctct cttcacccgt ctcatctgca caggacacca acaggtgctg ccttgttacc
      121 accatgccgg aagttgagag gaaatctaag atcactgcct cccgtaaact catgctgaag
      181 agcctgatgc tagccaaggc caaggagtgc tgggagcagg agcacgagga gcgagaggct
      241 gagaaggtgc gttacctctc ggagcgcatc cctacgctgc agacccgcgg tctttccctc
      301 agcgcccttc aggacttatg ccgagagctc catgccaagg tggaggtggt ggatgaggag
      361 cgctatgata tcgaagccaa atgcctccac aacacgagag agatcaagga cctgaagctg
      421 aaggtgctgg acctccgtgg gaagttcaag cgtccacccc tgcgccgggt ccgtgtctca
      481 gccgacgcca tgctccgagc cctactgggt tccaaacaca aggtgtccat ggatctgcgg
      541 gccaacctca agtctgtgaa gaaagaagac acagaaaagg agcggccagt ggaggtggga
      601 gactggagga agaacgtgga ggccatgtct ggcatggaag gccgcaagaa gatgttcgat
      661 gctgccaagt ccccaacctc gcagtagagg tgcttagagt gctcttcttg gtgcccctca
      721 gaatcttggg gcactcagga gaagggatgg gaggctgacc caacgtacag aactcttagg
      781 agtcagctct cttgggttca agcctactgc agtgtcttca gacactgggc acagcatgcc
      841 tgtgtcaggt ctttttttgc tgttgttgtt ccctcatcaa taaaacttgg gcttgtatgt
      901 ga
//
LOCUS       NM_001107994            2990 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus splA/ryanodine receptor domain and SOCS box
            containing 1 (Spsb1), transcript variant 3, mRNA.
ACCESSION   NM_001107994 XM_001075317 XM_233686
VERSION     NM_001107994.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Nishiya,T., Matsumoto,K., Maekawa,S., Kajita,E., Horinouchi,T.,
            Fujimuro,M., Ogasawara,K., Uehara,T. and Miwa,S.
  TITLE     Regulation of inducible nitric-oxide synthase by the SPRY domain-
            and SOCS box-containing proteins
  JOURNAL   J Biol Chem 286 (11), 9009-9019 (2011)
   PUBMED   21199876
REFERENCE   2  (bases 1 to 2990)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001107994.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158603.1, SRR26643293.31629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000005.1  165654050-165654225 c
            177-1018            JAXUCZ010000005.1  165650886-165651727 c
            1019-2990           JAXUCZ010000005.1  165641255-165643226 c
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2990
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
     exon            1..176
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     exon            177..1018
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    301..303
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="upstream in-frame stop codon"
     CDS             325..1146
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 1"
                     /protein_id="NP_001101464.1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
                     /translation="MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMP
                     PVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQI
                     TWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKT
                     YPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWG
                     HCEIRMRYVNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ"
     misc_feature    484..1005
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    484..1005
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    order(553..555,559..561,655..657,709..711,970..978)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    order(553..555,559..561,655..657,709..711,970..978)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    1018..1143
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    1018..1143
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    order(1021..1038,1054..1056,1084..1086,1102..1104)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     misc_feature    order(1021..1038,1054..1056,1084..1086,1102..1104)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     exon            1019..2990
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttcagata agcatgtgac gcacgggcgg cacccacgtt gtagatgaac agagggaaac
       61 tgggacaaac caaaatcgaa tcgtagtcgg tgtacaaggc acggtgtcct gagtgagttt
      121 gggagccttg gagacaggtc tggggacatg ccctgcgggc tacagcccag ggagaggcaa
      181 tacagagcgc ttcacaacct ttggaaatcg cctagcaacc tcccttaggg gttctgtgtg
      241 gccctgacta gaaatctgga atcaacgccc caagattgat gagtttgcct tgggagtcag
      301 tgaaaaggtg aaagaaaggc caacatgggt caaaaggtga cgggagggat caagactgtg
      361 gacatgcggg accccacata ccgacctcta aagcaggagc tccagggttt ggattattgc
      421 aagcccaccc ggctggacct gctgctcgac atgccccccg tgtcctacga tgtccagctg
      481 ctccactcct ggaacaacaa tgaccgttcg ctcaacgtct ttgtgaagga agatgacaag
      541 ttgatctttc accggcatcc ggtggcccag agcacggacg ccatcagggg caaagttggg
      601 tacacacgtg gactacacgt atggcagatc acatgggcca tgaggcaacg aggcacgcat
      661 gccgtggtgg gggtggccac agcagacgcc cctttgcatt ctgttgggta cacaaccctt
      721 gtaggaaata accatgaatc ctggggctgg gacctggggc gtaaccgtct ctaccacgac
      781 ggcaagaacc agccaagtaa aacataccca gccttcctgg agccagatga gactttcatt
      841 gtcccagact ccttccttgt ggccctggac atggatgatg ggaccttgag tttcatcgtg
      901 gatggacagt acatgggagt ggctttccgg ggactcaagg gtaaaaagct gtatcctgta
      961 gtgagtgccg tctggggcca ctgtgagatc cgcatgcgct acgtgaacgg acttgatcct
     1021 gagcccctgc cactcatgga cctgtgccgg cgttcggtgc gcctagcgct aggaaaggaa
     1081 cgtctgggtg ccatccccgc tctgccgcta cctgcctccc tcaaagccta cctcctctac
     1141 cagtgatccg catcccagga tcgccgtatg acagccacct ggtgccaact cactgagcct
     1201 ttggggtcca ccgacccctg cgcctgggat ggacgcccac cctcaggcat gggcagacgt
     1261 accctctcat cccaccagct gcctctgctg ggtggaccaa tgccaacgga cttctccctt
     1321 cccaacactg gctgaagcag cagcatccag gcccttccct gaaccagatg cagagaataa
     1381 actatgagaa cctctctcag gcgcctctgc tctccagtgg agtgggctgc ccccccacta
     1441 ctccctgaag agagagtcta cagccacctg ggggggttcc tgggaggtga gacgagtggg
     1501 agatgccggg gcagatccca aaagcaggaa tatgcaggac caggccacac cgatgaagct
     1561 caggatgtca cataccatgg acactgagac agaaccccag gctggacctc cctcgggcca
     1621 gctctagtgt cagctgccgg tgctccgtgc cctgtattta ttctttaaac agtagcaaag
     1681 gccgtttatt tattccactg agaaaggaaa ccttgttggg tggcttccct cgatgtgctc
     1741 tgttgctttc cccccacctg ccacctccct ggaatgtgtg tgccacaccc gtccttctcc
     1801 tggggccagg cctgtggcac gtgagctggt gtgcacagat acaagtatgt cattgtgtac
     1861 gacctttgac cccgttccca agtagctctg cgccaagcac cagagcagaa cctgagtccc
     1921 caggtacctg ctcctgttac ctggagcgtc catacaccat cacacgtgtt ttgatctctc
     1981 gtcttccgtg tgctttgaat tttgcccccc cccaattttt ctgatatttc ctgttgaatc
     2041 ctccaaagtt ctagacctgg aggaccatcg ggacaccggg ggtgagggga ggggtctcca
     2101 gcccctggga aagccacagg caaggcagga ttagaccttg tctcacacac acaccctcaa
     2161 gcctcagcag tggctgtagg gtggacagga cgggtgcctg tctcctgcag cacaccaatg
     2221 gagcaccact gctccggctc tctgggcatg tggtcggttg ggagagggct tgcctagcac
     2281 gcaggaagct caggttccat cccctgcacc aaggagaatc aaagctcagg aggctgaggc
     2341 agggggattg ctgttcagtg ctgtacagag gtcgtggaca tcccgggctg tattaaatct
     2401 tgtcctttaa gaaaaaaaga aaagaaacca acttccatcg aatctgagtt ctgttcattt
     2461 ctgcacaggt acagtagatg actttatttg ttgaaaatgt ttaatatatt tacatagata
     2521 tatttgtaag aatcatttta agcagctgct gtagggtacc ttttttaaaa aataaataaa
     2581 catcttccag tagagtataa tttttaaggc acagaggtgg tgccgagact agataaagaa
     2641 tctaagtcat tccctctgcg ttttgaggtc cttctccttt tttgggaggg gggccttttg
     2701 tcagacagaa atcttactcg ttctggtttt ggagcggatc acattcagcc gcatagatcc
     2761 cagcttgatc tccacccggc cgtaccctca cggatgctgg cgaacagcaa ggctctcctg
     2821 tgtcccccat actccgccgc cccaggactc accacacctc cctgccgtcc cggcaccatc
     2881 accgtaaagc cttgtggcat gtatagttct gaaatccccg ttctgttctg ttttatgatg
     2941 actcatatca gtcagtaacc taataaagga aagtttgtta aaatatgaaa
//
LOCUS       NM_012922               2481 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus caspase 3 (Casp3), transcript variant 2, mRNA.
ACCESSION   NM_012922
VERSION     NM_012922.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Niedermeyer,S., Yun,X., Trujillo,M., Jiang,H., Andrade,M.R.,
            Kolb,T.M., Suresh,K., Damarla,M. and Shimoda,L.A.
  TITLE     A novel interaction between aquaporin 1 and caspase-3 in pulmonary
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L638-L645 (2024)
   PUBMED   38375595
  REMARK    GeneRIF: A novel interaction between aquaporin 1 and caspase-3 in
            pulmonary arterial smooth muscle cells.
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Holota,R., Decmanova,V., Alexovic Matiasova,A., Kosuth,J.,
            Slovinska,L., Pacut,L., Tomori,Z., Daxnerova,Z. and Sevc,J.
  TITLE     Cleaved caspase-3 is present in the majority of glial cells in the
            intact rat spinal cord during postnatal life
  JOURNAL   Histochem Cell Biol 161 (3), 269-286 (2024)
   PUBMED   37938347
  REMARK    GeneRIF: Cleaved caspase-3 is present in the majority of glial
            cells in the intact rat spinal cord during postnatal life.
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Galichanin,K. and Yu,Z.
  TITLE     Expression of active caspase 3 in the rat lens after in vivo
            exposure to subthreshold dose of UVR-B
  JOURNAL   BMC Ophthalmol 24 (1), 29 (2024)
   PUBMED   38254051
  REMARK    GeneRIF: Expression of active caspase 3 in the rat lens after in
            vivo exposure to subthreshold dose of UVR-B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Li,C., Zhang,H., Mo,J., Zuo,J. and Ye,L.
  TITLE     Caspase-3/GSDME dependent pyroptosis contributes to offspring lung
            injury induced by gestational PFOS exposure via PERK/ATF4 signaling
  JOURNAL   Arch Toxicol 98 (1), 207-221 (2024)
   PUBMED   37955688
  REMARK    GeneRIF: Caspase-3/GSDME dependent pyroptosis contributes to
            offspring lung injury induced by gestational PFOS exposure via
            PERK/ATF4 signaling.
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Vito,P., Ghayur,T. and D'Adamio,L.
  TITLE     Generation of anti-apoptotic presenilin-2 polypeptides by
            alternative transcription, proteolysis, and caspase-3 cleavage
  JOURNAL   J Biol Chem 272 (45), 28315-28320 (1997)
   PUBMED   9353287
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Ni,B., Wu,X., Du,Y., Su,Y., Hamilton-Byrd,E., Rockey,P.K.,
            Rosteck,P. Jr., Poirier,G.G. and Paul,S.M.
  TITLE     Cloning and expression of a rat brain interleukin-1beta-converting
            enzyme (ICE)-related protease (IRP) and its possible role in
            apoptosis of cultured cerebellar granule neurons
  JOURNAL   J Neurosci 17 (5), 1561-1569 (1997)
   PUBMED   9030616
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Juan,T.S., McNiece,I.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Fletcher,F.A.
  TITLE     Molecular characterization of mouse and rat CPP32 beta gene
            encoding a cysteine protease resembling interleukin-1 beta
            converting enzyme and CED-3
  JOURNAL   Oncogene 13 (4), 749-755 (1996)
   PUBMED   8761296
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Liu,X., Kim,C.N., Yang,J., Jemmerson,R. and Wang,X.
  TITLE     Induction of apoptotic program in cell-free extracts: requirement
            for dATP and cytochrome c
  JOURNAL   Cell 86 (1), 147-157 (1996)
   PUBMED   8689682
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced NM_012922.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081854.1, SRR26360172.2159321.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000016.1  52413692-52413752   c
            62-129              JAXUCZ010000016.1  52405106-52405173   c
            130-254             JAXUCZ010000016.1  52402552-52402676   c
            255-383             JAXUCZ010000016.1  52400663-52400791   c
            384-559             JAXUCZ010000016.1  52399499-52399674   c
            560-680             JAXUCZ010000016.1  52398718-52398838   c
            681-2481            JAXUCZ010000016.1  52395539-52397339   c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2481
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="caspase 3"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
     exon            1..61
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    41..43
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="upstream in-frame stop codon"
     exon            62..129
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..910
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /EC_number="3.4.22.56"
                     /note="IRP; SCA-1; CASP-3; CPP-32; apopain; cysteine
                     protease CPP32; SREBP cleavage activity 1; protein Yama;
                     Caspase 3, apoptosis related cysteine protease (ICE-like
                     cysteine protease); CPP32beta; cysteine protease p32-beta"
                     /codon_start=1
                     /product="caspase-3"
                     /protein_id="NP_037054.1"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
                     /translation="MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEM
                     GLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDS
                     VSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFII
                     QACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQS
                     LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFY
                     H"
     misc_feature    77..79
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    107..109
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P70677; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    152..154
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); phosphorylation site"
     mat_peptide     161..601
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p17.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004591"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     misc_feature    185..907
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    185..907
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    order(266..268,440..442,557..559,578..580,686..703,
                     713..718)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(266..268,440..442,557..559,578..580,686..703,
                     713..718)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(437..439,563..565)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(437..439,563..565)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(581..583,641..646,665..667,674..676,683..685,
                     752..754,776..778,794..796,854..856,869..874,878..880,
                     887..892)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(581..583,641..646,665..667,674..676,683..685,
                     752..754,776..778,794..796,854..856,869..874,878..880,
                     887..892)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(584..586,638..640)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(584..586,638..640)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     mat_peptide     602..907
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p12.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004592"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     exon            130..254
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            255..383
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            384..559
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            560..680
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            681..2481
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgcagtgt tggtgttggt gggatcaaag cttagtgtcc tgaggtgcgg agcttggaac
       61 gcgaagaaaa gtgaccatgg acaacaacga aacctccgtg gattcaaaat ccattaataa
      121 ttttgaaaca aagactatcc atggaagcaa gtcgatggac tctggaatat atctggacag
      181 cagttacaaa atggattacc ctgaaatggg cttgtgtata ataattaata ataagaactt
      241 ccataaaagc actggaatgt cagctcgcaa tggtaccgat gtcgatgcag ctaacctcag
      301 agagacattc atggccctga aatacgaagt caggaataaa aatgacctta ctcgtgaaga
      361 aattatggaa ttgatggata gtgtttctaa ggaagatcac agcaaaagga gcagttttgt
      421 gtgtgtgatt ctaagtcatg gagatgaagg agtaattttt ggaacgaacg gacctgtgga
      481 cctgaaaaaa ctaactagtt tcttcagagg cgactactgc cggagtctga ctggaaagcc
      541 gaaactcttc atcattcagg cctgccgagg tacagagctg gactgcggta ttgagacaga
      601 cagtggaact gacgatgata tggcatgcca gaagatacca gtggaggccg acttcctgta
      661 tgcttactct accgcacccg gttactattc ctggagaaat tcaagggacg ggtcatggtt
      721 catccagtca ctttgcgcca tgctgaaact gtacgcgcac aagctggaat tcatgcacat
      781 cctcactcgt gttaaccgga aggtggccac ggaatttgag tccttctccc tggacgccac
      841 tttccatgca aagaaacaga tcccgtgtat tgtgtcaatg ctcacaaaag aactgtactt
      901 ttatcactaa aggaatgact gggagtgggg taggggcatg tttctgtttt ggtttttttt
      961 tttggttttt gttttttgtt tttttttttt tatttgaatg ccaaatgaga aaactgtcag
     1021 ggagactttt tttttcccct ctcatttaaa tcaaatccga tgttccaggt cgtcattgaa
     1081 caataccact gcctgcaatg cagccacaat acaatacctc agctttgata tcaggtagtt
     1141 gaaatgaaat ttaattagga acaaataaat gtcaataatg gtacaaccat catagaagaa
     1201 attggaaagt cacactttgg taattagaga gatttggtgc cactatgaat ttgaaattac
     1261 gaagcagtga tgatcttata ccccctcctc acatctagaa tgtcacttta gttttcgtta
     1321 agcataggaa cgataatgtc aagtggtatg tcttagaact tgaatccacg agcagagtca
     1381 aaggctggtt ttggaactga tctgtggaaa tgaagagttg gagcactgta gcacacatta
     1441 tagctactgg ttttgtgaca gttgaccagg tcacatattt attatttaag acaaaagtcg
     1501 tgttttatta ttggaacaaa aataacttta tatgagagga aaaccatgtg tgaacttggt
     1561 tggcttgttg aaggctacca tccttcagtg gtggacatga cgacagggtg ctacgatcca
     1621 ccagcatttg tttcttactt attcttatgc aaatcagcct aattttacag accagcaaaa
     1681 tatctaaaga gcgattatgc agcagcctca aattgttgac tattagaatg gaataaagga
     1741 attctacagg aacagaccat aataccagct gtcagtcaga gcgtaaggaa aggagaggtg
     1801 gcatctcctg tgattggaga gaagatggtt tgagccggag cagagccatg ggcacgtctt
     1861 cagaaaaggc ctgctagttg gacccacctt gtgagcactg gtctgtgtgg atgatgtcca
     1921 agttaccaca tgagactgaa ccagatcaga agctcctgca aaaaggcttt cccagagtgc
     1981 tgagcatctc aagaaagttc actggactcc atgtacagag tctgtagcat gctgactttt
     2041 ctgttgaagt ttacaatgaa aggaaaatga tggtgatatt tgtaccgtca ctagaaatga
     2101 agggccctgg cacacgggac ttggaaagca tccagcaata ggccctgcag cccatgtgga
     2161 ggagctgcag actggagtcc acccctcctc cccatcaggg cgtctgtgct ccaggcttcc
     2221 ttaatcatgg aggtgctgag tcatcgctgg ctctccctgt gggtccagca tttcccataa
     2281 gcctccttat tgcacaaaga aaggaaggaa ctcacattat aactgatagt aggttcttgt
     2341 ttagactgga tttactgtta actcttttct aagtaaatac agcatgtggt ggtattttaa
     2401 aatgtgttcc catgtgacaa ttttataaaa gtcagatatc ttgcattttt atttcaaaac
     2461 ataaattcag atttaaaatt a
//
LOCUS       NM_001436941             819 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 9, mRNA.
ACCESSION   NM_001436941 XM_063287907
VERSION     NM_001436941.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 819)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 819)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 819)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 819)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 819)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 819)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 819)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 819)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 819)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063287907.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.991906.1,
                                           SRR26360181.1773401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000005.1  61744292-61744375   c
            85-208              JAXUCZ010000005.1  61743399-61743522   c
            209-247             JAXUCZ010000005.1  61743164-61743202   c
            248-315             JAXUCZ010000005.1  61741422-61741489   c
            316-375             JAXUCZ010000005.1  61741152-61741211   c
            376-819             JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..819
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..84
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            85..208
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             206..532
                     /gene="Ccl27"
                     /note="isoform e is encoded by transcript variant 9; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform e"
                     /protein_id="NP_001423870.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MEEWSSEDGCAGPAEPFGARDMSRLRRYEVALEAEEEIYWGCFY
                     FFPWLRMWRRERSSAHPREQKLEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQT
                     AGALKI"
     exon            209..247
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            248..315
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            316..375
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            376..819
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaatagag gagaaagaaa agtggccagc acgaacagaa acagccctca agaaatctac
       61 ttcatagagc tgtcatgaga caagactcag acaagttgca tcctggacct gcttcccatg
      121 tctctcatcc ctacttccct aaattctctg tgaactgacc aacatctctc ctcaaaaacc
      181 cctcaaccct caagaaaggg agagcatgga ggagtggagt tcagaggatg gctgcgcagg
      241 ccctgcagaa ccgttcggag ctcgagacat gtcgcgattg aggagatacg aggtggcgct
      301 ggaagcggag gaggagatct actggggctg cttctacttt tttccttggc tgcgaatgtg
      361 gcgcagggag cggagctcgg cgcacccccg ggagcagaag ctggagcctc tgcggggcct
      421 aatgagctgt ttgtcgagcg gcctgaggcc tgctccccag cgctcaggtc gcggtctcct
      481 ctgtcgcacc cccaccgctg ctgcacagac agccggtgca ttaaagattt aaagtcacgc
      541 ccactgcctt cctgacttta ccgccgcagc cgccactggt gctgggaatc ccactccaca
      601 cctgctgttt cttagcccac agggcatccc tccctggtag gaagcccttg catgtctaag
      661 cctccaatgt ccctaaaggt caagctgcca attactatca gtgactggct ccctgccacg
      721 ccctccccaa aagcacccac actgagagtg taggccacat ctgtccacca cttcccagta
      781 ttcccacaac ttcagctatt accatcttcc tctagccgt
//
LOCUS       NM_001436944             849 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 12, mRNA.
ACCESSION   NM_001436944
VERSION     NM_001436944.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 849)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1920693.1,
                                           SRR26360181.2473773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000005.1  61741422-61741766   c
            346-405             JAXUCZ010000005.1  61741152-61741211   c
            406-849             JAXUCZ010000005.1  61740594-61741037   c
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..849
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..345
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     CDS             299..562
                     /gene="Ccl27"
                     /note="isoform f is encoded by transcript variant 12; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform f"
                     /protein_id="NP_001423873.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSSAHPREQK
                     LEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQTAGALKI"
     exon            346..405
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..849
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaaatc tccattcagg gcctaaacgt cccagctata ctgccgctag acccctctcc
       61 ttggtgactc cacgttccgg tccctagata gccatcctcc taacgcttta acttgtagtg
      121 atttccatat catccatccc atcctgtccc gatgtgacca ttggcttccg ggagggccac
      181 ctgcctcagt gtacctgagt attcagactt gtcctgggaa tgatggaaaa gggaacttgc
      241 aactgggaat aagtgttcct atcatgctgc tccccaggaa ccgttcggag ctcgagacat
      301 gtcgcgattg aggagatacg aggtggcgct ggaagcggag gaggagatct actggggctg
      361 cttctacttt tttccttggc tgcgaatgtg gcgcagggag cggagctcgg cgcacccccg
      421 ggagcagaag ctggagcctc tgcggggcct aatgagctgt ttgtcgagcg gcctgaggcc
      481 tgctccccag cgctcaggtc gcggtctcct ctgtcgcacc cccaccgctg ctgcacagac
      541 agccggtgca ttaaagattt aaagtcacgc ccactgcctt cctgacttta ccgccgcagc
      601 cgccactggt gctgggaatc ccactccaca cctgctgttt cttagcccac agggcatccc
      661 tccctggtag gaagcccttg catgtctaag cctccaatgt ccctaaaggt caagctgcca
      721 attactatca gtgactggct ccctgccacg ccctccccaa aagcacccac actgagagtg
      781 taggccacat ctgtccacca cttcccagta ttcccacaac ttcagctatt accatcttcc
      841 tctagccgt
//
LOCUS       NR_199185               2934 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 18, non-coding
            RNA.
ACCESSION   NR_199185
VERSION     NR_199185.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2934)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2934)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2934)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2052116.1,
                                           SRR26643292.55530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1732           JAXUCZ010000016.1  17498298-17498369
            1733-1856           JAXUCZ010000016.1  17503674-17503797
            1857-1907           JAXUCZ010000016.1  17504488-17504538
            1908-2044           JAXUCZ010000016.1  17505392-17505528
            2045-2105           JAXUCZ010000016.1  17508313-17508373
            2106-2188           JAXUCZ010000016.1  17509056-17509138
            2189-2394           JAXUCZ010000016.1  17531082-17531287
            2395-2934           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..2934
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2934
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     misc_RNA        1..2934
                     /gene="Eps15l1"
                     /product="epidermal growth factor receptor pathway
                     substrate 15-like 1, transcript variant 18"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..2206
                     /gene="Eps15l1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001029921.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1732
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1907
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2044
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2105
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2188
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2394
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2934
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggatgatcc
     1741 tttcaaaaac aaagccttgt tgtttagcaa caactctcaa gagctgcatc cagacccctt
     1801 ccaggcagag gaccccttca agtctgaccc atttaaagga gctgatccct tcaaaggtga
     1861 ccctttccag agtgatccct tctcagagca gcagacagca gttacagacc catttggagg
     1921 ggaccctttc aaagaaagtg acccattcca tagctcaacc agtgatgact tcttcaagaa
     1981 acagacaaag aatgacccgt ttacctcaga ccccttcaca aagaaccctt ccttaccttc
     2041 aaagctcgac ccattcgagt ccagtgatcc cttctcatcc tccagcatct cctcgaaagg
     2101 ttcagatccc ttcggaacac tagacccctt tggaagcagc tccttcagca gtgccgaggg
     2161 tttcgctgac ttcagtcaga tgtccaaggt cagagtacac ctgtaagcca gctgggttct
     2221 tcagccttcc ctgaatcccc tgatccattc cagccactcg aggctgacag cggcgacccg
     2281 ttccaaaata aaaaggggtt tggggaccca tttagtggca aagatccatt tgccccttcc
     2341 tcttcagcta aacctcctaa ggcctcttct tccggctttg ccgacttcac ctcttttggc
     2401 aatgaggagc agcagctggc ctgggccaaa cgggagagtg agaaagcgga gcaggagcgg
     2461 ctggcgaggc ttcggcgaca ggaacaggag gacctggagc tggccatcgc cctcagcaag
     2521 gccgatatgc cggcctaggt gacacagggg aagccgcagc tgtctgtatg tccacatcat
     2581 gctcagagcg tgcccccttc aagccaagcc atgccacagc caaggacagc tggccacagg
     2641 gcctcaggcc acagggacct tgttgagagg tagcagacac agcccacgcc tgtgggtggg
     2701 ccaggaaggc agccttcggt aaaaggcctg gaacctgcct gtctctgagg tgtcagtcag
     2761 gctcttcctt ccaatcattc agtgactgac ggagaaggcc tccagtctcc tagctacaga
     2821 caagctccac cccaaccctt cctcacatcc acaagacacc ctgcacacat gatgtatgca
     2881 ttcgttgtat aaaaatgaag tttgaatgat taatataaaa tattttaata caaa
//
LOCUS       NR_199181                767 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 4, non-coding RNA.
ACCESSION   NR_199181
VERSION     NR_199181.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 767)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.531145.1,
                                           SRR26643298.71756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000016.1  62495163-62495479   c
            318-542             JAXUCZ010000016.1  62494663-62494887   c
            543-767             JAXUCZ010000016.1  62493153-62493377   c
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..767
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     misc_RNA        1..767
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /product="tRNA methyltransferase 9B (putative), transcript
                     variant 4"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..317
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            318..542
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            543..767
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggtgagaga caggaaggtc atcctgattc
      181 cagcctcagg cacgtccggg cgcggcgatc gcaggggaca gacagagcgg ccacaccgct
      241 tgggctctgc cgcgcgcccg cgccgcaccg agccgactcc gaggcgcccc gggcttgcgg
      301 tcagagcctg gggagaggcc gacccatgga agttgcatcc tggacagtcc gggctgcgac
      361 gctgaagagc accgagccag tgctcggccg agcctcccgc ccggatcccg ggcaaagacc
      421 gcccaaaacc tgctgttgac cttcgtctgc actgctcaat ggtgacccga gtcttcgctg
      481 tcctagttgc agccatttgg catccccaag actgccagag cacccgggat ctgcaaacct
      541 ggcctaatct tactgatgct tggaggactg taaacaagaa gtgctaactg ggcttagtcc
      601 tgaaggaccc tgcttctgac tctcaaggtt cagtcactgc tttgaagacg tcacaagccg
      661 gacccagctg gcaatacaca gcatcttaac attgagagaa aagttcgtgg tggtgctctg
      721 gctgagcgtt ttaaacagga cctgagtaaa agatgtcatt gaaatga
//
LOCUS       NR_199184               2497 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 7, non-coding RNA.
ACCESSION   NR_199184
VERSION     NR_199184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71755.1, CK842271.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000016.1  62495163-62495479   c
            318-542             JAXUCZ010000016.1  62494663-62494887   c
            543-731             JAXUCZ010000016.1  62470460-62470648   c
            732-2497            JAXUCZ010000016.1  62459224-62460989   c
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2497
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     misc_RNA        1..2497
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /product="tRNA methyltransferase 9B (putative), transcript
                     variant 7"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..317
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            318..542
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            543..731
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            732..2497
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggtgagaga caggaaggtc atcctgattc
      181 cagcctcagg cacgtccggg cgcggcgatc gcaggggaca gacagagcgg ccacaccgct
      241 tgggctctgc cgcgcgcccg cgccgcaccg agccgactcc gaggcgcccc gggcttgcgg
      301 tcagagcctg gggagaggcc gacccatgga agttgcatcc tggacagtcc gggctgcgac
      361 gctgaagagc accgagccag tgctcggccg agcctcccgc ccggatcccg ggcaaagacc
      421 gcccaaaacc tgctgttgac cttcgtctgc actgctcaat ggtgacccga gtcttcgctg
      481 tcctagttgc agccatttgg catccccaag actgccagag cacccgggat ctgcaaacct
      541 ggggcttgga ttctcttcag agactcatac tgagtggtgg atcttgtgaa gggctcacta
      601 actcaattcc tgctcctttc atgtgtgtta tatactgaga gccctgagaa ggaactgttc
      661 ctccctgagg aaggaaactg ccgtgattta ccaaaaccag aaataatcca catgatcaca
      721 aaatgagtca ggatggatcc cgaagccgtg cagctggaga agcagcacgt gcacaaggtc
      781 tatgagagca ccgcccccta cttcagtgac cttcaaaaca aagcttggcc ccgcgtccgc
      841 cagttcctgc aggaccagaa gccaggcagc ctcatcgctg acattggtaa cccatacttc
      901 tgttttgccg tatgtgatct cttattaaac cgacacaacc ttcctaatgc cgcagtcctt
      961 taatacagtt cctcgtgttg tggtgacccc caccccaacc ataaaattat tttgttgcta
     1021 cttcatagct gcaactttgc tactgttatg aatcgtaatg tgaatatctg atatgcagcg
     1081 tatctgagat gtgacccgca ggttgaaaac ggctgcttta aagtgttcac tttagagcaa
     1141 aaattcacgt catcaaagac accaagcaga aaacatctcc caactatact tagagatcct
     1201 ttatgtacat cctgcatcaa caccaacctg tcacagatag aatcaaataa ggacggaaac
     1261 gatgccacgt tagacgtttt cagtttagag actctcacat ttggaggacg agttttgtat
     1321 tcttggctca tgttgagtgg ttccatattc ttttatgaaa gaaccagact tgtgagatta
     1381 tgaacaaagt cttacaccct ttcatttctc tgatggatct ctccttcccc aacccctgtt
     1441 tataggcatc ttattgctag ggtatgcctt taattgagta gtacctccat aattgttgat
     1501 ttatctggag aacttcagca tctttctgaa ttgagaagta gtcaaccaca gttgaagact
     1561 gaggtttaag gtgtgattgg actccacgtt ccaggaatca caagcttgct acagttaact
     1621 cactcttagt ctgggttgac atcagtctta atactgacag gagaaactgc tgggtgtgtg
     1681 cccagcatat gacagaggat ataagcagtc cagagtttaa aaagaggtac ctaccatgct
     1741 gaaggtgaga gtccaaagaa gctctctagc atgtcagttt ttaaaaccaa atacggtttc
     1801 ctggggtcag ggatgtggct cagggatggt atgcgtgctc tctgtgttca gagccctgcg
     1861 ttcaaatccc actgccacaa aatggagaaa ggtatctgat tttagagact gcaacaagct
     1921 caaaggtcct actgtccact gtccggtgtc catgcaaagt gtaagacttt cacacggctg
     1981 gggaggaaag gggcaattca ctaaggaggt ttaggagagc agcatataaa ataaggtggt
     2041 gtttttctta tatcttatgt ctaaataaat tctaaaatgc agcaaaggtt taagtgtaag
     2101 aaaatgaaat taagaaggtt agtgaagggc tggagagatg actcagccat taaaggctag
     2161 gctcacaacc aaatatataa gaaggttagt gaaattacct ttaaaattat cctgatacat
     2221 aaggcttctc tgtgcctttt gtatgtttgt ttgtttggtt ggttggttgg tttttggttt
     2281 tgggaacggg gcttcccttg tagccctggc tgtcctgaat cccactaccc agatcagtct
     2341 ggcctctctg ccacagagaa cgtcctgcct ttgcctccca agtgctggga ctaaaggtgt
     2401 gcactactct ctcccagtgc ctctctctac cggtatgcgt ctctcttgcc catgctttaa
     2461 aaatcgtctc taagaaaaat aaattggttg tcatact
//
LOCUS       NR_199182                602 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 5, non-coding RNA.
ACCESSION   NR_199182
VERSION     NR_199182.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 602)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ208443.1, SRR26360190.1556893.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000016.1  62495328-62495479   c
            153-377             JAXUCZ010000016.1  62494663-62494887   c
            378-602             JAXUCZ010000016.1  62493153-62493377   c
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..602
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     misc_RNA        1..602
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /product="tRNA methyltransferase 9B (putative), transcript
                     variant 5"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..152
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            153..377
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            378..602
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggccgaccc atggaagttg catcctggac
      181 agtccgggct gcgacgctga agagcaccga gccagtgctc ggccgagcct cccgcccgga
      241 tcccgggcaa agaccgccca aaacctgctg ttgaccttcg tctgcactgc tcaatggtga
      301 cccgagtctt cgctgtccta gttgcagcca tttggcatcc ccaagactgc cagagcaccc
      361 gggatctgca aacctggcct aatcttactg atgcttggag gactgtaaac aagaagtgct
      421 aactgggctt agtcctgaag gaccctgctt ctgactctca aggttcagtc actgctttga
      481 agacgtcaca agccggaccc agctggcaat acacagcatc ttaacattga gagaaaagtt
      541 cgtggtggtg ctctggctga gcgttttaaa caggacctga gtaaaagatg tcattgaaat
      601 ga
//
LOCUS       NR_199183               2332 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 6, non-coding RNA.
ACCESSION   NR_199183
VERSION     NR_199183.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2332)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71754.1,
                                           SRR26360194.1558210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000016.1  62495328-62495479   c
            153-377             JAXUCZ010000016.1  62494663-62494887   c
            378-566             JAXUCZ010000016.1  62470460-62470648   c
            567-2332            JAXUCZ010000016.1  62459224-62460989   c
FEATURES             Location/Qualifiers
     source          1..2332
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2332
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     misc_RNA        1..2332
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /product="tRNA methyltransferase 9B (putative), transcript
                     variant 6"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..152
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            153..377
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            378..566
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            567..2332
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggccgaccc atggaagttg catcctggac
      181 agtccgggct gcgacgctga agagcaccga gccagtgctc ggccgagcct cccgcccgga
      241 tcccgggcaa agaccgccca aaacctgctg ttgaccttcg tctgcactgc tcaatggtga
      301 cccgagtctt cgctgtccta gttgcagcca tttggcatcc ccaagactgc cagagcaccc
      361 gggatctgca aacctggggc ttggattctc ttcagagact catactgagt ggtggatctt
      421 gtgaagggct cactaactca attcctgctc ctttcatgtg tgttatatac tgagagccct
      481 gagaaggaac tgttcctccc tgaggaagga aactgccgtg atttaccaaa accagaaata
      541 atccacatga tcacaaaatg agtcaggatg gatcccgaag ccgtgcagct ggagaagcag
      601 cacgtgcaca aggtctatga gagcaccgcc ccctacttca gtgaccttca aaacaaagct
      661 tggccccgcg tccgccagtt cctgcaggac cagaagccag gcagcctcat cgctgacatt
      721 ggtaacccat acttctgttt tgccgtatgt gatctcttat taaaccgaca caaccttcct
      781 aatgccgcag tcctttaata cagttcctcg tgttgtggtg acccccaccc caaccataaa
      841 attattttgt tgctacttca tagctgcaac tttgctactg ttatgaatcg taatgtgaat
      901 atctgatatg cagcgtatct gagatgtgac ccgcaggttg aaaacggctg ctttaaagtg
      961 ttcactttag agcaaaaatt cacgtcatca aagacaccaa gcagaaaaca tctcccaact
     1021 atacttagag atcctttatg tacatcctgc atcaacacca acctgtcaca gatagaatca
     1081 aataaggacg gaaacgatgc cacgttagac gttttcagtt tagagactct cacatttgga
     1141 ggacgagttt tgtattcttg gctcatgttg agtggttcca tattctttta tgaaagaacc
     1201 agacttgtga gattatgaac aaagtcttac accctttcat ttctctgatg gatctctcct
     1261 tccccaaccc ctgtttatag gcatcttatt gctagggtat gcctttaatt gagtagtacc
     1321 tccataattg ttgatttatc tggagaactt cagcatcttt ctgaattgag aagtagtcaa
     1381 ccacagttga agactgaggt ttaaggtgtg attggactcc acgttccagg aatcacaagc
     1441 ttgctacagt taactcactc ttagtctggg ttgacatcag tcttaatact gacaggagaa
     1501 actgctgggt gtgtgcccag catatgacag aggatataag cagtccagag tttaaaaaga
     1561 ggtacctacc atgctgaagg tgagagtcca aagaagctct ctagcatgtc agtttttaaa
     1621 accaaatacg gtttcctggg gtcagggatg tggctcaggg atggtatgcg tgctctctgt
     1681 gttcagagcc ctgcgttcaa atcccactgc cacaaaatgg agaaaggtat ctgattttag
     1741 agactgcaac aagctcaaag gtcctactgt ccactgtccg gtgtccatgc aaagtgtaag
     1801 actttcacac ggctggggag gaaaggggca attcactaag gaggtttagg agagcagcat
     1861 ataaaataag gtggtgtttt tcttatatct tatgtctaaa taaattctaa aatgcagcaa
     1921 aggtttaagt gtaagaaaat gaaattaaga aggttagtga agggctggag agatgactca
     1981 gccattaaag gctaggctca caaccaaata tataagaagg ttagtgaaat tacctttaaa
     2041 attatcctga tacataaggc ttctctgtgc cttttgtatg tttgtttgtt tggttggttg
     2101 gttggttttt ggttttggga acggggcttc ccttgtagcc ctggctgtcc tgaatcccac
     2161 tacccagatc agtctggcct ctctgccaca gagaacgtcc tgcctttgcc tcccaagtgc
     2221 tgggactaaa ggtgtgcact actctctccc agtgcctctc tctaccggta tgcgtctctc
     2281 ttgcccatgc tttaaaaatc gtctctaaga aaaataaatt ggttgtcata ct
//
LOCUS       NR_199186               3027 bp    RNA     linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15-like 1 (Eps15l1), transcript variant 19, non-coding
            RNA.
ACCESSION   NR_199186
VERSION     NR_199186.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3027)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3027)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3027)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50077.1,
                                           SRR26643290.47520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000016.1  17460466-17460532
            68-109              JAXUCZ010000016.1  17475200-17475241
            110-199             JAXUCZ010000016.1  17475660-17475749
            200-247             JAXUCZ010000016.1  17476358-17476405
            248-343             JAXUCZ010000016.1  17480016-17480111
            344-406             JAXUCZ010000016.1  17480725-17480787
            407-532             JAXUCZ010000016.1  17484548-17484673
            533-592             JAXUCZ010000016.1  17487957-17488016
            593-826             JAXUCZ010000016.1  17490212-17490445
            827-984             JAXUCZ010000016.1  17492273-17492430
            985-1141            JAXUCZ010000016.1  17494375-17494531
            1142-1227           JAXUCZ010000016.1  17494770-17494855
            1228-1300           JAXUCZ010000016.1  17495977-17496049
            1301-1462           JAXUCZ010000016.1  17496416-17496577
            1463-1660           JAXUCZ010000016.1  17497016-17497213
            1661-1825           JAXUCZ010000016.1  17498298-17498462
            1826-1949           JAXUCZ010000016.1  17503674-17503797
            1950-2000           JAXUCZ010000016.1  17504488-17504538
            2001-2137           JAXUCZ010000016.1  17505392-17505528
            2138-2198           JAXUCZ010000016.1  17508313-17508373
            2199-2281           JAXUCZ010000016.1  17509056-17509138
            2282-2487           JAXUCZ010000016.1  17531082-17531287
            2488-3027           JAXUCZ010000016.1  17535167-17535706
FEATURES             Location/Qualifiers
     source          1..3027
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3027
                     /gene="Eps15l1"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     misc_RNA        1..3027
                     /gene="Eps15l1"
                     /product="epidermal growth factor receptor pathway
                     substrate 15-like 1, transcript variant 19"
                     /db_xref="GeneID:361120"
                     /db_xref="RGD:1565708"
     exon            1..67
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..2299
                     /gene="Eps15l1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001029921.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            68..109
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..199
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..247
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..343
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..406
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..532
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..826
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..984
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1300
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1462
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1660
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1825
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1949
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2000
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2137
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2198
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2281
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2487
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..3027
                     /gene="Eps15l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttggcgc tcgggaggcc gagtccgcac gaagatggcg gctccactcc tacccctctc
       61 gcagcagatt cccagtggaa acccattata cgagtcttac tacaagcagg tggaccctgc
      121 ctacacaggg agagttgggg caagcgaggc tgcactgttt ctgaagaagt cagggctctc
      181 agacatcgtc ctgggaaaga tatgggactt ggcagacccc gaaggtaaag ggttcttgga
      241 caaacagggt ttctatgttg cactgagact ggtggcctgt gcacagagtg ggcacgaagt
      301 taccttgagc aacctgggcc tcaccatgcc accaccaaaa ttccatgata ccagcagccc
      361 actgatggcc acacagtcat ctgcagaggc ccactgggcc gtgcgggtgg aggagaaggc
      421 aaagtttgat ggcatctttg aaagccttct accagtcaat ggactactct ctggagacaa
      481 ggtcaagccg gtcctcatga actcaaaact acctctggat gtgctgggca gggtctggga
      541 cctcagtgac attgacaagg atggacattt ggaccgagat gagtttgctg tggctatgca
      601 cttggtatac cgcgccctgg agaaggaacc agtgccctcc gttctgcccc cgcccctcat
      661 cccaccctcc aagaggaaga agacggtatt tgcaggcgct gtgcctgtct tgcctgccag
      721 ccccccaccc aaagacagcc tccgctccac accatcccat ggcagtgtaa gcagcctcaa
      781 cagcacaggc agcctgtccc caaagcacag cgtcaagcag actcagccac cagtggcctg
      841 ggttgtgcct gtagctgata agatgcgctt tgacgagatc ttcttgaaga cagacctgga
      901 ccttgatggc tatgtgagtg gccaggaagt taaggagatc ttcatgcact caggcctcac
      961 acagaacctt ctagcacaca tctgggccct ggccgataca agacaaacgg gcaagttaag
     1021 caaagagcaa tttgcgctag caatgtattt cattcagcag aaggtcagta aaggcatcga
     1081 ccctcctcaa gtcctctcgc ctgacatggt gccaccctcg gagagaggca ctcccattcc
     1141 agacagttca agtgctcttg ggtcaggaga gttcactggt gtgaaagagc tggatgacat
     1201 cagccaggag atcgcacagc tgcagagaga gaaatattca ctggaacaag acatcagaga
     1261 aaaggaagag gcaatcagac agaaagccag cgaagtacag gaattacaaa atgacctgga
     1321 ccgagaaact agtagtctgc aggaacttga ggctcagaaa caggatgctc aggaccgcct
     1381 ggatgagatg gaccagcaga aggctaagct gcgggacatg ctgagtgacg tgcggcagaa
     1441 atgccaggat gagacccaga cgatctcatc attgaaaacc cagatccagt ctcaggagtc
     1501 agacttgaag tcccaggagg atgacctgaa ccgggccaag tcagagctga atcggctgca
     1561 gcaggaggag acacagctgg agcagagcat ccaggctggg cgcgcgcagc tggagaccat
     1621 cctcaggtcc ctgaagtgca cacaggatga catcaaccag gcaagaagca agctgtccca
     1681 gctacaggaa agccacctag aagctcaccg gagcctggaa cagtacgacc aggtgcctga
     1741 tggggtctct ggtaccagcc tgcctgacct ggccaccttg aatgaaggca tcttgctggc
     1801 agagaggggc ggctttggag ccatggatga tcctttcaaa aacaaagcct tgttgtttag
     1861 caacaactct caagagctgc atccagaccc cttccaggca gaggacccct tcaagtctga
     1921 cccatttaaa ggagctgatc ccttcaaagg tgaccctttc cagagtgatc ccttctcaga
     1981 gcagcagaca gcagttacag acccatttgg aggggaccct ttcaaagaaa gtgacccatt
     2041 ccatagctca accagtgatg acttcttcaa gaaacagaca aagaatgacc cgtttacctc
     2101 agaccccttc acaaagaacc cttccttacc ttcaaagctc gacccattcg agtccagtga
     2161 tcccttctca tcctccagca tctcctcgaa aggttcagat cccttcggaa cactagaccc
     2221 ctttggaagc agctccttca gcagtgccga gggtttcgct gacttcagtc agatgtccaa
     2281 ggtcagagta cacctgtaag ccagctgggt tcttcagcct tccctgaatc ccctgatcca
     2341 ttccagccac tcgaggctga cagcggcgac ccgttccaaa ataaaaaggg gtttggggac
     2401 ccatttagtg gcaaagatcc atttgcccct tcctcttcag ctaaacctcc taaggcctct
     2461 tcttccggct ttgccgactt cacctctttt ggcaatgagg agcagcagct ggcctgggcc
     2521 aaacgggaga gtgagaaagc ggagcaggag cggctggcga ggcttcggcg acaggaacag
     2581 gaggacctgg agctggccat cgccctcagc aaggccgata tgccggccta ggtgacacag
     2641 gggaagccgc agctgtctgt atgtccacat catgctcaga gcgtgccccc ttcaagccaa
     2701 gccatgccac agccaaggac agctggccac agggcctcag gccacaggga ccttgttgag
     2761 aggtagcaga cacagcccac gcctgtgggt gggccaggaa ggcagccttc ggtaaaaggc
     2821 ctggaacctg cctgtctctg aggtgtcagt caggctcttc cttccaatca ttcagtgact
     2881 gacggagaag gcctccagtc tcctagctac agacaagctc caccccaacc cttcctcaca
     2941 tccacaagac accctgcaca catgatgtat gcattcgttg tataaaaatg aagtttgaat
     3001 gattaatata aaatatttta atacaaa
//
LOCUS       NM_001107229            8076 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus DEP domain containing 5, GATOR1 subcomplex
            subunit (Depdc5), transcript variant 1, mRNA.
ACCESSION   NM_001107229 XM_001065993 XM_223584
VERSION     NM_001107229.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8076)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   2  (bases 1 to 8076)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   3  (bases 1 to 8076)
  AUTHORS   Marsan,E., Ishida,S., Schramm,A., Weckhuysen,S., Muraca,G.,
            Lecas,S., Liang,N., Treins,C., Pende,M., Roussel,D., Le Van
            Quyen,M., Mashimo,T., Kaneko,T., Yamamoto,T., Sakuma,T., Mahon,S.,
            Miles,R., Leguern,E., Charpier,S. and Baulac,S.
  TITLE     Depdc5 knockout rat: A novel model of mTORopathy
  JOURNAL   Neurobiol Dis 89, 180-189 (2016)
   PUBMED   26873552
  REMARK    GeneRIF: DEP-domain containing 5 knockout rats exhibit multiple
            features of rodent models of mechanistic target of rapamycin
            complex 1 (mTOR) mTORopathies, and thus, stand as a relevant model
            to study their underlying pathogenic mechanisms.
REFERENCE   4  (bases 1 to 8076)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   5  (bases 1 to 8076)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   6  (bases 1 to 8076)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   7  (bases 1 to 8076)
  AUTHORS   Dibbens,L.M., de Vries,B., Donatello,S., Heron,S.E., Hodgson,B.L.,
            Chintawar,S., Crompton,D.E., Hughes,J.N., Bellows,S.T., Klein,K.M.,
            Callenbach,P.M., Corbett,M.A., Gardner,A.E., Kivity,S., Iona,X.,
            Regan,B.M., Weller,C.M., Crimmins,D., O'Brien,T.J.,
            Guerrero-Lopez,R., Mulley,J.C., Dubeau,F., Licchetta,L.,
            Bisulli,F., Cossette,P., Thomas,P.Q., Gecz,J., Serratosa,J.,
            Brouwer,O.F., Andermann,F., Andermann,E., van den Maagdenberg,A.M.,
            Pandolfo,M., Berkovic,S.F. and Scheffer,I.E.
  TITLE     Mutations in DEPDC5 cause familial focal epilepsy with variable
            foci
  JOURNAL   Nat Genet 45 (5), 546-551 (2013)
   PUBMED   23542697
REFERENCE   8  (bases 1 to 8076)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223584.4, XM_001065993.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..8076
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..8076
                     /gene="Depdc5"
                     /note="DEP domain containing 5, GATOR1 subcomplex subunit"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
     exon            1..69
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            70..192
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            193..280
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            281..327
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            328..417
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    403..405
                     /gene="Depdc5"
                     /note="upstream in-frame stop codon"
     exon            418..501
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..4848
                     /gene="Depdc5"
                     /note="isoform 1 is encoded by transcript variant 1; DEP
                     domain-containing protein 5; GATOR complex protein DEPDC5;
                     GATOR1 complex protein DEPDC5"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform 1"
                     /protein_id="NP_001100699.1"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
                     /translation="MWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYIS
                     EETRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHE
                     VTVVLFSRTFYDAKSIDEFPEVNRASIQQDHKGRFYEDFYKVVVQNERREEWTSLLVT
                     IKKLFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQ
                     MSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPR
                     DSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSATEKTKNGRDTSLGAPK
                     ESENTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHNRKSASSCDVSSSPS
                     LPSRALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIE
                     PPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTF
                     PVGPSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDS
                     MSLNFSGTEELSVSLLSNSGTGMNPRNQNKDSLEDGVSTSPDPMPGFCCTVGVDWKSL
                     TTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVFEEFICQ
                     RLMQGYQIIVQPKTQKPSTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMGRTFHKV
                     TLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFCHERLEEYKWNYL
                     DQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKPRADEDE
                     WQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLESTGPPVGKKG
                     TSALSALLEMEASQKSLGEQQTSVHGKSSTQPAENSSVAMTPTYVDSPRKASVDQTAP
                     LVLDSTSLGVSTCQSVDRGNNQTFGNSQNIEQAFPSTGSGDGSSQQHIASSLTSSSTL
                     VEILEAMKHPSTGVQLLSEQKGLSPCCFISAEVVHWLMNNVEGVQTQAMGIDIMQKML
                     EEQLIAHASGEAWRTFVYGFYFYKIVTDREPERVAMQQPSAPWHTAGVDDFASFQRKW
                     FEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ
                     RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTATVLFEMVQGWHRKA
                     TSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNLGCLLKEGSEHLFDSFEPETYWD
                     RMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQR
                     RRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINR
                     DNRLVTFWTNCLEKMHASAP"
     misc_feature    478..1281
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    478..1281
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    3571..3816
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3571..3816
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3868..4791
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     misc_feature    3868..4791
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     exon            502..551
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            552..621
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            622..700
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            701..762
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            763..832
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            833..905
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1009
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1084
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1219
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1281
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1355
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1425
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1462
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1583
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1804
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2008
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2144
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2239
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2305
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2462
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2623
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2741
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2909
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3129
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3263
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3369
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3521
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3599
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3732
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3841
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..4069
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4070..4239
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..4411
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4412..4472
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4555
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..8076
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcggcggt gctgtctgtc tggctcctag agctctggtg cggaagctgc gcgaactgtg
       61 ggggctcagt agcaggaagg caagatgact tccctgctcc aagatcggaa cagctgaaga
      121 aaccacaaga caaaatgaga accacaaagg tctacaaact tgtcatccac aagaagggct
      181 ttgggggcag tgatgatgag ctggtcgtga accctaaagt ctttcctcac atcaaacttg
      241 gagacattgt ggagatcgct caccccaatg atgaatacag tcctttgctt ttgcaagtca
      301 agtctcttaa ggaagattta cagaaagaaa ctatcagtgt ggaccagact gtgacacaag
      361 tattccggct aagaccttat caagatgtct atgtaaacgt tgtagacccc aaggcaagat
      421 gtgactcttg acctagtgga attgactttt aaggatcagt atataggccg gggggatatg
      481 tggcgactaa agaaaagttt ggtgagcacc tgtgcctata tcacccagaa agtggaattt
      541 gctggcatca gggcacaggc tggtgagctg tgggtcaaga atgagaaggt catgtgtggt
      601 tacattagtg aagagaccag ggtggtgttc cgttctacgt cggctatggt ttacatattt
      661 attcagatga gctgtgaaat gtgggatttt gatatttatg gggatctgta ctttgagaaa
      721 gctgtgaatg gtttccttgc cgacctgttt actaagtgga aggagaagaa ctgtagccat
      781 gaagtgactg tggttctgtt ttctagaact ttttatgatg caaaatctat tgatgaattt
      841 cctgaagtaa accgagcttc aattcaacag gatcataaag ggagattcta cgaggacttt
      901 tacaaagtgg tggtgcagaa cgagagaagg gaagagtgga cgtcactcct tgtgaccatt
      961 aagaaactct tcatccagta tccagtgttg gttcgactgg aacaggcagg gggctttcct
     1021 caaggagaca attctacctc agcacaagga aactacctag aggccatcaa cttgtcattc
     1081 aatgtgtttg acaagcacta catcaaccga aactttgacc gaactgggca gatgtccgtg
     1141 gtgatcacgc cgggggtggg tgtctttgaa gtggaccgcc tcctcatgat cttgaccaag
     1201 cagcggatga tcgataatgg aattggtgtg gacttagtgt gcatgggaga gcagccatta
     1261 cacgctgtgc cattattcaa gctgcacaac cggagtgtgc cacgggattc tcggctgggc
     1321 gatgactata atattcctca ctggataaac cacagtttct acacatccaa aagccagctg
     1381 ttttgtaaca gtttcactcc aaggataaaa ctggcaggaa agaagtctgc cactgagaaa
     1441 accaaaaatg gccgtgatac atctcttggg gctccaaagg aatctgaaaa cacccttccc
     1501 atccaagtag attatgatgc ctacgatgcc caagtattcc ggctgcctgg tccatcccgg
     1561 gcccagcgac tcgccacctg caggtctgtg agagagcagg aaaatcacaa tcgcaaaagt
     1621 gccagctcct gtgacgtctc ctccagccct tccttgccaa gccgtgcact gcccactgag
     1681 gaagtgagga gccaggcttc agacgacagc tccctgggca agagcaccaa catcctgatg
     1741 atccctaacc cccatctgca ccagtatgaa gtcagcagct cactgggcta caccagcacc
     1801 cgagatgtcc tggagaacat gatagaacca ccacagcggg actctagtgc acctggaagg
     1861 ttccacgtgg gcagtgcaga gtccatgcta catgttcgac ctggaggcta cacccctcag
     1921 agagcactga ttaacccctt cgccccctca agaatgccca tgaagctcac ctccaacaga
     1981 aggcgctgga tgcatacttt tcctgtagga ccatctggag aggccatcca gatccatcat
     2041 caaacccggc aaaacatggc agagctgcag ggcagcaggc agcgggaccc cacccactcc
     2101 tctgcagaac tgttggagct ggcatatcat gaagccgcag gaaggcacag cacttcccga
     2161 cagcctggtg acagcatgtc cttgaacttc agtggaacgg aagagctttc tgtcagcctg
     2221 cttagcaaca gcggcacagg tatgaatcct aggaaccaga ataaggactc tctagaggat
     2281 ggtgtttcta cctctccaga cccaatgcca ggcttctgtt gcacagttgg agtggattgg
     2341 aagtctctta ctactcctgc atgccttccc ctcaccactg actacttccc ggaccgtcag
     2401 ggcctgcaga atgactacac agagggctgc tatgatctcc tcccagaagc agacatggac
     2461 aggagggacg aggagggcgt tcaaatgaca gcccagcaag tgtttgaaga gttcatctgc
     2521 cagcgtctca tgcagggtta ccaaatcata gtacagccaa agacccagaa gcccagcact
     2581 acagtcccac ccccgctgag cagtagccca ctctatagca gaggccttgt gtcccgaaac
     2641 cgccctgaag aggagggcca gtattggctg agtatgggca gaaccttcca taaggtgaca
     2701 cttaaggaca agatgatcac agtgactcgt taccttccca agtaccctta tgaatctgcc
     2761 cagatccatt acacctacag cctctgccct tcccactctg actcagagtt tgtctcctgt
     2821 tgggtggaat tctgccatga acggctagag gaatacaagt ggaattactt agatcagtac
     2881 atttgttctg ccggctccga agatttcagc ttaatcgagt ctctgaagtt ctggagaacc
     2941 cgatttctac tactgccagc ctgtgtcact gccaccaagc gcatcacaga aggggaagtg
     3001 cactgtgaca tctacgggga caaaccccgt gcagatgaag atgagtggca gcttctagat
     3061 ggctttattc gctttgtaga gggcttgaac cgcatccgca ggcgccaccg gtcagaccgc
     3121 atgattcgga aagggactgc catgaaaggc ttgcagatga ccgggcccat ctccgcacac
     3181 tctctcgagt caacgggccc cccagtcggg aagaaaggaa cctcagctct gtctgccctg
     3241 ctggagatgg aggctagtca gaagagccta ggagaacagc agacaagtgt gcatgggaaa
     3301 agctctactc agccagctga gaacagcagt gttgccatga ctcccaccta tgtggacagc
     3361 ccacgcaagg catctgtgga ccaaacagct cctctggtgt tggacagcac cagtttaggg
     3421 gtcagcacgt gccagtccgt ggatagaggc aataaccaga cctttgggaa ctcccagaac
     3481 atagaacagg cctttccctc tacaggctct ggagacggca gctctcagca gcacatagcc
     3541 agctctctga catcgtcctc taccctggtg gagatcctgg aagccatgaa gcatccctcg
     3601 acaggagtcc agctgctgtc tgagcagaag ggcctttcgc cgtgctgctt catcagtgcg
     3661 gaggtcgtac actggctgat gaacaatgtg gagggggtcc agacgcaggc gatgggcatc
     3721 gacatcatgc agaaaatgct ggaagagcag ctcatagcgc atgcatctgg agaagcatgg
     3781 cgaaccttcg tctacggctt ctatttctac aagatagtca cggacagaga gcccgaacga
     3841 gtggctatgc agcagccctc tgccccatgg cacacagcag gagtggatga ctttgccagc
     3901 ttccaacgca agtggtttga ggtggccttt gtggcagaag agcttgtgca ctccgagatt
     3961 cctgccttcc tcctgccctg gctacctagc cggccagcct cttacgcaag caggcacagc
     4021 tcctttagcc gaagttttgg aggacggagc caggcagctg cactgttagc tgccactgtc
     4081 ccagagcaga ggactgtgac cctggatgtc gatgtgaaca accgaacgga ccggctggag
     4141 tggtgcagct gttactacca cggaaacttc tctctcaacg cagcctttga aatcaagcta
     4201 cactggatgg cagtgactgc cacagtgctg tttgagatgg tccaaggttg gcatcgaaaa
     4261 gctacatcct gcggcttctt gttagtcccg gttttggagg gtccttttgc actgcccagt
     4321 tacctgtacg gtgacccctt gagggcccag ctcttcatcc cgctcaacct cggctgcttg
     4381 ctcaaggagg gcagcgagca cctgttcgat agctttgaac cagagacata ttgggatcga
     4441 atgcaccttt tccaggaagc cattgcacac aggtttggat ttgtgcaaga taaatattct
     4501 gcctccgcgt ttaacttccc tgctgagaat aaaccacagt atatccacgt cacaggaaca
     4561 gtgtttcttc agctgccgta ctccaaacgc aagttttctg ggcagcagcg gcggcgacgg
     4621 aactctacca gctccaccaa ccaaaacatg ttctgtgagg agcgggttgg ctacaactgg
     4681 gcctataaca ccatgctgac caagacatgg cgctctagtg ccacggggga tgagaagttt
     4741 gccgatcggc tgctgaagga cttcacggat ttctgtatca accgtgacaa ccgcctggtc
     4801 acattctgga caaactgcct ggagaagatg cacgccagcg ctccctgacg ccaggctgct
     4861 ccattaggag aggctgtggg tatcctggag ctggctgtcc agctaggctc tgggcatcag
     4921 gtgtcaggct gctcctgtca gcgagtgggg ccactgctga tatttggcct cttgcacaag
     4981 tgtgagtgag gagaaagact ggaagcagct gctgttgcta ccaccaccca gatctcgcca
     5041 tcacgtgccc gaggcagggg gaggcacaga ttgtccgtgg gagggagtca gtgtctggga
     5101 atggggtagg cagcttccat taaggtcctt tttcctcacc agcagtggga tatttggaac
     5161 agaaagaacc tcctgctttc tgcccaagaa tgtgtgtgta taggataatt ctgtgacata
     5221 gtgtaccatt gcctcatacc agctgtacat acgtgtacat agcagaagtg aataaagccc
     5281 cccacacagt gtctgttccc agccttgttc atagcagcag tcccatcatg gctggcagct
     5341 ggccaggcag gtcacctggt ggcgagaggg ctgcgggaca cacgggtctt gagtctgcct
     5401 atgagttgac tggtaggttt ctttttaaaa gtccttttgc aggaacaagg atcctgtgga
     5461 cagtattact cagtacaaca cagtactaga cttgtgttgt cagagagagg cctcgttgag
     5521 gggctgtacc agctcagggg agcagacatc atggcatttc tgacatccaa ggaaagctct
     5581 tggctctaga ctgctcgggg gaggcaaagg cctagaggag cgtctggtag ttgtggctgc
     5641 tgctccctca cgtgctagag cttatcacac tccccattga tgtaccttct aaccagcttt
     5701 cccatccttt acctctcctg ggcctgtgtg cagctgcagg cccagccctc ctgtctttct
     5761 cttacctcta ggaaaaccta acttgtctct ggatcatcct actgtattct cctgggaaac
     5821 tgggtttttg ttgtttattt gtcaacaaca aaagcaggat acagcggctt gtacctgtaa
     5881 tatcagtgtt tcggaggcta aggcaggagg attatggagt tccaggccag gctggcctcc
     5941 acagtgtgtg ttcttagcaa ggtcgagctc tgcagtgaga ctgccttaga aagtctcact
     6001 ttgggctgga aagatgactc cgttaagagc acttgactga tcttacagag gacctgagtt
     6061 cagtgccagc acccatgagg tcactcacga ccatccataa ctggagttcc aagggacccc
     6121 acaccctctt ctgacctcct ttggcatcag gcacacatgt aaacaaacat atatccacat
     6181 gcaaacaaag tactcatcac ataacacaaa aataaatctt aaaaacgaac aggcagctcc
     6241 actacattta gacttagaat tctcctcact acctagtcca aaacccttag gtagggtgct
     6301 ggatttgcag atcagagcca acacaatagg caccaggccc tggactcaat tcatagcatc
     6361 acagaagtat agcggtgaag cattgtctag cctgatgggc tttttcactg ctgccttggg
     6421 agtagcgcat ccttcaaacc agacttaacc agctcaaatc tgcatatacc gtgccaagct
     6481 gtactcacct ggaacttcta atcacaagta ttaagtcctg tgtgcaaagg ctttttcttt
     6541 taaggttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacgca
     6601 cgcgcacgta catcagatcc cctggagcta gagtctagat gtttgtgagc caccatgtag
     6661 gtgctgggaa gtgagcctgc aagtgctctc agtggctgag ccacgtccct ggcttgtgca
     6721 tgtgaagctt ttgagagagt aagctgctaa cgtgggaaag tgtgattcat gggaagctta
     6781 gcttttccca ccccccaccc tttcttctga atattactcc tctcactgtc agtcttcttg
     6841 tcagtaggag ctgtccagag tagctgggtt gaggcaggta cagctgactt gtggcgtgta
     6901 cctgtaaccg aagcacttga gagacccagg gagaggggag aagcctgctg tggacttgag
     6961 gccactccag gacacacaca caaaggacag cttcatttga aagaactgag aagacagcaa
     7021 atctctagtt ctcgctctcc cagatgggcc tgttcagggt gccatgccag ccttctctgt
     7081 gatagtgctg gtcactgttg gccaggcctg accaggtgat ctgctgtggt cctgttatcc
     7141 atcctgcaaa accaccaatt gcctcttcac atacagtttt tgtcatagtc cagaggtaac
     7201 ttggaagaca atgatctgac agaagatcaa ctgatgaatt ggaaccaggt cacttgcctg
     7261 tcagctgatt ctgaggcgtt cctgaccttg agctccagtt cctgcagtct agcattccag
     7321 attccagtgc actgccctct tccatcaaca cctacttagc cagccagaca acttggctac
     7381 ctccccccat ccctggtgcc cgacttcaga gccttgcctc aggggagcta cagtctaaaa
     7441 tgtgtcccca ctaaggtctc atgcattaga agcttaaccc tgagcctggt atggtgacac
     7501 aggactctaa tcccagtact agggaggcaa agactaatga ctaagaggtc tctgtgagct
     7561 cgaggttagc ctgatcaaca agctgagtcc caggacagaa gagcacacca actatgtata
     7621 agcccctgga tccatccaca gctctaacat atatgtttca aaacaaactt ggggttgggg
     7681 atttagctca gtggtagagc gtttgcctag caagcgcaag gccctgggtt cggtccccag
     7741 ctccgaaaaa aaaaaaaaaa aaggaaaaaa gagaagaaga aaaaagttaa aaacaagctc
     7801 agcattaaag ggaatgaggg gccagctcaa taaatagagg tgcttgcctt cggtgattta
     7861 agttcagttc ctcagaccca tatggtggaa agaatcaacc tcagaaagtt ctctgacatc
     7921 cacacacaag ttgtggtacc catgtatcca catatataca tacatgcaca aattaattga
     7981 attttttaaa ataaaatata ttgaggtctg cgaaggttca caaaagtgga tagaaaatag
     8041 gagggaagca gaatgcaagc cagttcatag ttctct
//
LOCUS       NM_001108351            3197 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus SERTA domain containing 4 (Sertad4), transcript
            variant 2, mRNA.
ACCESSION   NM_001108351 XM_001069683 XM_341174
VERSION     NM_001108351.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341174.3, XM_001069683.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00155308, SAMD00155321
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..3197
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA domain containing 4"
                     /db_xref="GeneID:360899"
                     /db_xref="RGD:1565408"
     exon            1..175
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     exon            176..367
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1293
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /codon_start=1
                     /product="SERTA domain-containing protein 4"
                     /protein_id="NP_001101821.1"
                     /db_xref="GeneID:360899"
                     /db_xref="RGD:1565408"
                     /translation="MTLVLSMNRFCEPIVSEGAAEIAGYHTLWEADSYGGASPPGPAH
                     VPSQGDRGAGPQLAGSHYRGISNPVSTPKVTYFKRKYAEEEELPTPLSSCSHKTISIF
                     EERAHILYMSLEKLRFIDDPEVYLRRSVLINNLMKRIHGEIVMQNSWYLPACSLSGTS
                     AQEWFLAQDCPYRKRPRVAKQEWEKFHTCCFYQECGGHCLNLPLSVSDGVGSASAAAV
                     ASPASSSSSPSTSSPSSPSSSSSSLSSPLPLPSCSHHVDFDVGSAPIYKSQVPASEIF
                     VTNVRSLGVQEKIKFNSDGKVSHETSRDGNALGQEPVGNDLDFECKGQFYDYFETGYT
                     ERNRMSESWKKSLRKKELSPSNKLCCSRGGKM"
     misc_feature    514..618
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA motif; Region: SERTA; pfam06031"
                     /db_xref="CDD:461806"
     misc_feature    514..618
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA motif; Region: SERTA; pfam06031"
                     /db_xref="CDD:461806"
     exon            368..483
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     exon            484..3197
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccacgccc ccgcctttac cagcctcctc ggccccgcaa ctttcccgag cgccccacat
       61 caggagcggg gcaccaaggt ccaccctagc tctagcggcg cgcacagcgc gggcggcagc
      121 agctcggcga aggaccaggg cagctgcggg ctggagtgtg gccctgccag ccgctatcta
      181 aggctgttag agatgacgct ggttctgtcc atgaatagat tctgcgagcc cattgtctca
      241 gaaggagctg ctgaaattgc cgggtaccac acactatggg aggctgacag ctacggaggt
      301 gcgagccccc cagggccagc acatgttcct tcacagggag accggggagc cggcccacaa
      361 ctggcaggat cacattacag ggggatttca aaccctgtaa gcacacccaa ggtcacgtac
      421 ttcaagagga agtatgcgga agaagaggag cttcccacac cgctcagcag ctgcagccat
      481 aagaccatct ccatttttga ggagcgagca cacatccttt acatgtcctt ggagaaactc
      541 aggttcatcg atgacccaga agtgtacctg cgaaggtcag tccttatcaa caatctgatg
      601 aagaggatcc acggggagat cgtcatgcag aacagctggt acctccctgc ctgctccctc
      661 agtggcacct ctgcccaaga gtggttcctg gctcaagact gtccttaccg gaaacggccc
      721 cgggtggcca aacaggagtg ggaaaagttc cacacttgct gtttttacca ggagtgtggc
      781 ggtcactgcc tgaacctacc cctctctgtc agtgatggtg tcggaagcgc ttcggccgct
      841 gccgtggcct cacctgcttc ttcctcttcc tccccatcca cctcttctcc atcctcccca
      901 tcctcctcgt cctcgtcctt gtcctcccct ctgcctctgc ccagttgttc ccaccacgtg
      961 gactttgacg taggcagtgc gcctatttac aagagccaag ttcctgccag cgaaatcttt
     1021 gtcactaacg ttaggtcgct tggtgtccag gaaaagatca agttcaacag cgacgggaaa
     1081 gtaagtcacg aaaccagcag agatggcaac gccctgggcc aagaacctgt gggaaacgac
     1141 ctcgattttg agtgcaaagg ccaattttat gattatttcg agactggata taccgagaga
     1201 aaccgtatga gtgagtcttg gaaaaagtct ttgaggaaaa aggagctttc cccaagcaac
     1261 aaactgtgct gcagcagagg gggtaaaatg tgaccccccc tcccccaccc ccaactggcg
     1321 cagaagcacg cacagcatga tcggttttta ctttgggttt tgtagttttg tacaaccgat
     1381 aaaatcacgc agtgaacacg cccggtcgtc tcactgcccg gagagcagat tgcacaaaac
     1441 atctgtacag taggcatcca caagccactt attaatgtga tttttgccaa ggaaagccaa
     1501 cttcatgttt caaagtatat cctagtttcc tttttttcta aaaaaaaaaa aattaaaaaa
     1561 aaaaatcagt agagtagatc gaagacaaca tgcccttgtt atgttcccac tgcccctcca
     1621 cggagcctgc cgctagccaa gttcaacatg tttgccggtt aattaggtag ttacttggta
     1681 aacaaatcaa tataaccagc aaaggtgcct gcttcgatgt gatacggtat tttttccccc
     1741 tgagtgaaag actgaaggca ggaagctaga tgaagtggtt tcgtgagctg tgacatgttt
     1801 gtactggaca ggttggggcg aaatgaagca cacctgtcag gcagcagtct aggctctgtg
     1861 gagtcagttc cctacaagct cctggcttgc ctgtgatggc tagtgggtgg ctagagaggg
     1921 gtgtgcaggg ccacctctga cggggtcaca gggaggtgat gtacagagcc gtctctgatg
     1981 gggcgagtag gaggtggcac acagagccat ctttgatggg gtggctagag aggtggcgta
     2041 cagggccatc ttggtgatgg ggtgataggt ggcgtatagg gccatcttgg gtgccttact
     2101 ttatcttaat ttttgccagt gtgaaaatta aggacgaatc agagttacag cagggatttg
     2161 acaaaacaca gggtggatcc atgcagtttg gaagcttaac tttgaactat cgtgttcaac
     2221 tttcaagtta ccctccccct ttttcctttg tttatgacta agcccagtgg ctgtgagtct
     2281 gatatttttg cgtagagacg gagaagacag tggggaaggc catcaggaac agagaaggct
     2341 gcctgggttc tccatggcaa cgagcggttg ctgggtctgg actctcccag ctttgggctg
     2401 ttttgtttcc ttgtccagtg acattcacag cccgtgcgtg gcatgcgtta tatttttgac
     2461 ctgtttttgc atcatttcat gcgtttagac tcttaagagc atgtggtttc tatatacgaa
     2521 tttttgctgt tgattgagaa gcacaatgtt aatagattat gtggtgatca atatgtttta
     2581 tcttaaagaa tgtaaaggtt tgtaggttgc tgaacgttat tttggagaaa tggggctctc
     2641 tcgtcattga tactgttgtg tatttggccg acacactcct caataccttg aatttgcaca
     2701 ttggcaagtg tcctcagtgc tactctggag cagtcccacc agctccccgt gaactactcc
     2761 catctccaag gccaaggact ggtctgggtg acctgggtct cttaaaaacc attatttaca
     2821 ggaaacaaat gccaaaagga agaaataggt aagttctccc actttctcca agatgaagct
     2881 ttttaattat tgctattgat attaaatagg tctcattcat acagtgtatg agtagatcgt
     2941 ttgggcaatt gtccgcaagg accaattttc taaagatgtt cctgtgttat ggctgaatag
     3001 tctagtaatg tctcgtcctt tattttcaat atttgatgaa cattttggtg ttggaaattt
     3061 agctgataga tgcttgtaca tgactgtgtt gtaatatagt gaggttttct tgatatatat
     3121 ttattaaaac gatcaaaatt cattacgttt ttacaaattt cattttagtg gctatttctc
     3181 tttttcgtgt ttttctg
//
LOCUS       NM_001106068            2160 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 3 (B3gnt3), transcript
            variant 2, mRNA.
ACCESSION   NM_001106068 XM_001069599 XM_224719
VERSION     NM_001106068.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Shiraishi,N., Natsume,A., Togayachi,A., Endo,T., Akashima,T.,
            Yamada,Y., Imai,N., Nakagawa,S., Koizumi,S., Sekine,S.,
            Narimatsu,H. and Sasaki,K.
  TITLE     Identification and characterization of three novel beta
            1,3-N-acetylglucosaminyltransferases structurally related to the
            beta 1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 276 (5), 3498-3507 (2001)
   PUBMED   11042166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474031.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_224719.2, XM_001069599.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132295
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2160
                     /gene="B3gnt3"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /db_xref="GeneID:290638"
                     /db_xref="RGD:1305151"
     exon            1..75
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            76..650
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1229
                     /gene="B3gnt3"
                     /EC_number="2.4.1.146"
                     /note="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 3 precursor"
                     /protein_id="NP_001099538.1"
                     /db_xref="GeneID:290638"
                     /db_xref="RGD:1305151"
                     /translation="MRLPRLRPVVSLLLALAALLLLLTCQSPPSCPAPESPTEPKDDP
                     AWAPDLSRAHAAPCRANLSVSAHPAFARLPSHVRDFLLYRHCRDFAVLREPKATKCAQ
                     PAFLLLAIKSSPANYGRRQVLRTTWARERRVRGASLRRLFLVGSDRDPQQARKFNRLL
                     ELEAKAYGDILQWDFHDSFFNLTLKQVLFLEWQRTHCTNASFVLNGDDDVFAHTDNMV
                     TYLQGRDPDQHLFVGHLIQNVGPIRVPWSKYFIPTLVTAEDKYPPYCGGGGFLLSRFT
                     MAALHRAARVLPIFPIDDVFLGMCLQQQGLAPGAHSGVRTAGVLPPSPRVSSFDPCFY
                     RDLLLVHRFLPFEMLLMWDALSRPQLACGRQSPPLLTGLGGRHP"
     sig_peptide     93..164
                     /gene="B3gnt3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    447..1016
                     /gene="B3gnt3"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     misc_feature    447..1016
                     /gene="B3gnt3"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     exon            651..2160
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtaagga aagagaacgg ggaaagaggc ggagtaaggc gagctgccaa gagccagggc
       61 gaggcggacg cccaggcccc gtctcccacg ccatgcggct gccgcggctg cgccctgtcg
      121 tgagcctcct cctggccttg gccgccttgc tgctgctcct gacctgccag tcaccaccca
      181 gctgccccgc ccccgagagt cccacggagc ctaaggatga ccccgcgtgg gccccggacc
      241 tctcccgcgc gcacgccgcc ccgtgccggg ccaatctgtc ggtgtccgca caccccgcct
      301 tcgcgcggtt gccctcgcac gtgcgcgact tcctgctcta ccgccactgc cgcgacttcg
      361 cggtgcttcg ggagccgaag gcgaccaagt gcgcgcagcc cgcgttcctg ctgctcgcta
      421 tcaagtcctc gcccgcgaac tacgggcgcc gccaggtgct gcgcacgacg tgggcgcgtg
      481 agagacgagt acgcggggcg tcgctgcgcc gcctcttcct cgtgggctca gaccgcgatc
      541 cccagcaggc gcgcaaattc aaccggctgc tagagctgga ggcaaaggca tacggcgaca
      601 ttctccagtg ggatttccat gactccttct ttaacctgac acttaagcag gtccttttcc
      661 tggagtggca gcgaacccac tgtaccaacg ccagtttcgt gctcaacggg gacgacgacg
      721 tgttcgccca tacggacaac atggtcacct acctgcaggg ccgcgacccg gaccaacacc
      781 tcttcgtggg gcacctgatc cagaacgtgg gtcccattcg agtgccctgg agcaagtact
      841 tcatccccac tctggtgaca gctgaggaca agtacccgcc ctactgcggc ggcggcggct
      901 tcctgctgtc acgctttacc atggccgcgc tacatcgcgc agcgcgcgtc ctccccatct
      961 tccccatcga cgacgtgttc ctgggcatgt gtctgcagca gcaggggttg gcgcccgggg
     1021 cgcatagcgg agtgcgcacg gcgggtgtgc tcccccctag cccgcgtgtg tcatccttcg
     1081 acccctgctt ctaccgtgac ctgctcctcg tgcaccgctt cctgcccttc gagatgctgc
     1141 tgatgtggga tgcgctgagc cggcctcagc tcgcctgcgg caggcagagc ccccccctac
     1201 tgacaggttt ggggggtcga cacccctgac tcctgtcctc attcaagtgc aaagggttaa
     1261 ctaactacaa ggagaggttc aaagtgagga gcagcaaggt gggtctgagc cggctaccgt
     1321 ctgccgggca aactcctaag tacacttgga aaccctcctc gtactgctca gggcacactc
     1381 tgagtgggct ctgagaggct gctaagcaaa aagtgctgtg ggtagagccc atgggtgtca
     1441 ggctcccgcc tcagactggg ccatggcctt tctcaggtct cgaagaaatt ggggcagagg
     1501 aacaaggtga atttcaaatt gaggagctca caaatcttga cttgaccccc actagtgtcc
     1561 tccaagaact aggagaacca caggggtagg aagggtcctg tgtcccacag atggagatgg
     1621 caggaaataa agaccataga aggctgaagg tgacagtgta ctgtgtgttg tgggtgtgtg
     1681 tgatgtaacc cggggctctg ccatcttttt attttattat ttaggaaagg agccgggtcc
     1741 tgccttcctc tgcgtgcctc ctggggctta aactcggatc ctcatgcttg gcaacaggca
     1801 ccttcattca ctgagccctc tcaccagccc cttttagttt cccacactac tcaaatttta
     1861 acaccatctg ccctgcccca cctctctctg accttcaata ttaactaaag aaacaaacaa
     1921 atcctcaggt gtcactgtaa cacattccca tctacagcat ggctgtatgt gtctccagtc
     1981 cccctcctct cctgtagcta ctttgtggtt tcttttgctt ccaaccttgc aatgccccct
     2041 aacaccagtt aagagaggga aaaaggatag agaggaagga aaggagatct ctgaataaag
     2101 cctcaggact tggaaagagg tgacactatt gttagattcc ttgggggcga gtttcatctt
//
LOCUS       NM_001107237            2023 bp    mRNA    linear   ROD 24-MAR-2025
DEFINITION  Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001107237 XM_001056046 XM_223600
VERSION     NM_001107237.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Young,G.P., Symonds,E.L., Nielsen,H.J., Ferm,L., Christensen,I.J.,
            Dekker,E., van der Vlugt,M., Mallant-Hent,R.C., Boulter,N., Yu,B.,
            Chan,M., Tevz,G., LaPointe,L.C. and Pedersen,S.K.
  TITLE     Evaluation of a panel of tumor-specific differentially-methylated
            DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of
            colorectal cancer
  JOURNAL   Clin Epigenetics 13 (1), 14 (2021)
   PUBMED   33478584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Sharma,B., Shah,R., Jamwal,R.S., Verma,S., Bhat,A., Bhat,G.R.,
            Bakshi,D., Singh,S., Angurana,S., Bhat,A., Vaishnavi,S. and
            Kumar,R.
  TITLE     Evaluation of newly identified Ikaros family zinc finger 1 loci in
            colorectal cancer
  JOURNAL   J Cancer Res Ther 17 (1), 46-50 (2021)
   PUBMED   33723131
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Musher,B.L., Melson,J.E., Amato,G., Chan,D., Hill,M., Khan,I.,
            Kochuparambil,S.T., Lyons,S.E., Orsini,J. Jr., Pedersen,S.K.,
            Robb,B., Saltzman,J., Silinsky,J., Gaur,S., Tuck,M.K.,
            LaPointe,L.C. and Young,G.P.
  TITLE     Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1
            to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC)
  JOURNAL   Cancer Epidemiol Biomarkers Prev 29 (12), 2702-2709 (2020)
   PUBMED   32958500
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Zhao,W., Chen,T.B. and Wang,H.
  TITLE     Ikaros is heterogeneously expressed in lung adenocarcinoma and is
            involved in its progression
  JOURNAL   J Int Med Res 48 (8), 300060520945860 (2020)
   PUBMED   32787735
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Symonds,E.L., Pedersen,S.K., Murray,D., Byrne,S.E., Roy,A.,
            Karapetis,C., Hollington,P., Rabbitt,P., Jones,F.S., LaPointe,L.,
            Segelov,E. and Young,G.P.
  TITLE     Circulating epigenetic biomarkers for detection of recurrent
            colorectal cancer
  JOURNAL   Cancer 126 (7), 1460-1469 (2020)
   PUBMED   31909823
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Boggs,S.S., Trevisan,M., Patrene,K. and Geogopoulos,K.
  TITLE     Lack of natural killer cell precursors in fetal liver of Ikaros
            knockout mutant mice
  JOURNAL   Nat Immun 16 (4), 137-145 (1998)
   PUBMED   10366784
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Molnar,A. and Georgopoulos,K.
  TITLE     The Ikaros gene encodes a family of functionally diverse zinc
            finger DNA-binding proteins
  JOURNAL   Mol Cell Biol 14 (12), 8292-8303 (1994)
   PUBMED   7969165
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474055.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056046.1, XM_223600.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680417 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2023
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
     exon            1..198
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    144..146
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="upstream in-frame stop codon"
     exon            199..252
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1499
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein Ikaros"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros isoform 1"
                     /protein_id="NP_001100707.1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
                     /translation="MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQ
                     NSKSDRGMGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTG
                     HLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGMYPVIKEETNHSEM
                     AEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSANYEKDEMMTSH
                     VMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQD
                     SAVENLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHITPHARNG
                     LALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGC
                     HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS"
     misc_feature    <213..>602
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <213..>602
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    381..449
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    381..449
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    387..449
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    387..449
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(402..404,408..410,414..416,420..425,432..437,
                     444..446,486..488,492..494,504..509,516..521,528..530,
                     570..572,576..578,582..584,588..593,600..605,615..617)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(402..404,408..410,414..416,420..425,432..437,
                     444..446,486..488,492..494,504..509,516..521,528..530,
                     570..572,576..578,582..584,588..593,600..605,615..617)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    423..500
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    423..500
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    471..533
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    471..533
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    555..620
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    555..620
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            253..369
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            370..537
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            538..660
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            661..795
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            796..2023
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcctgac tctacgcagg cactcagtgc ctgacatgcc tgggagaggt ctgcggagcc
       61 gtggagcgtg gtgcaggatt gccttgctcc cacctctgcc cacagacccc ttccacgctg
      121 gcgcgtgcac acaggccggg atgtaaggcg ccatcctaac ttctgccgta agcaggtggg
      181 agggaagaga cgcgagagat aatctgaaga caatggatgt cgatgagggt caagacatgt
      241 cccaagtttc aggaaaggag agccctccag tcagtgacac tccggatgaa ggggatgaac
      301 ccatgcctgt ccccgaggac ctgtccacct ctggagcaca gcagaactcc aagagtgatc
      361 gaggcatggg tgaacggcct ttccagtgca accagtgtgg ggcctccttt acccagaaag
      421 gcaacctact gcggcacatc aagctgcact cgggcgagaa gcccttcaaa tgccatctct
      481 gcaactatgc ctgccgccgg agggacgccc tcaccggcca cctaaggacg cactccgttg
      541 gtaagcctca caaatgtgga tattgtggcc ggagctataa acagcgaagc tctttagaag
      601 aacataaaga gcgatgccac aactacttgg aaagcatggg cctcccgggc atgtacccag
      661 tcattaagga agaaactaac cacagcgaaa tggcagagga cctgtgcaag ataggagcag
      721 agaggtccct tgttctggac aggctggcca gcaacgtcgc caaacgtaag agctctatgc
      781 ctcagaaatt tcttggagac aagtgcctgt cagacatgcc ctatgacagt gccaactatg
      841 agaaggatga gatgatgaca tcccacgtga tggaccaggc catcaacaat gccattaact
      901 acctgggggc tgagtccctg cgcccgttgg tgcagacacc ccctggtagc tccgaggtgg
      961 tgccggtcat cagttccatg taccagctgc acaagccccc ctcagacggc ccaccacggt
     1021 ccaaccactc agcacaggac agcgccgtgg agaacttgct gctgctgtcc aaggccaagt
     1081 ccgtgtcatc agagcgggag gcctccccaa gcaacagctg ccaagactcc acggatacag
     1141 agagcaacgc ggaggaacag cgcagcggtc tcatctacct aaccaaccac atcactccgc
     1201 atgcgcgcaa cgggctggct ctcaaggagg agcagcgcgc ctacgaggtg ctgagggcag
     1261 cctcagagaa ctcgcaggac gccttccgtg tggtcagcac gagtggtgag cagctgaagg
     1321 tgtacaagtg cgaacactgc cgcgtgctct tcctggatca tgtcatgtac accatccaca
     1381 tgggctgcca tggcttccgg gatccctttg agtgtaacat gtgtggttat cacagccagg
     1441 acaggtacga gttctcttcc cacatcacac ggggggagca tcgctaccac ctgagctaaa
     1501 cccagccagg ccccactgaa gcacaaagat agctgggcat gcctctttcc cagcagctgg
     1561 acccacggcg gacaatgttg ggagtggatt tgcaggcagc atttgttctt ttacgttggt
     1621 tgtttgagat ttgatttgcg tttagaagac aagtttttaa tgttagagac aggattccat
     1681 tgcatcagga acgttcagaa cacccatcct tctagacggt tttgttgact gctagctgag
     1741 atttccctgg tatgtggctt cctaacgctc tccctacccg ccccaccccc aaaacagagc
     1801 ccgaatcttc agagaaatta attaaacaat tacccaagta ggagcaaggt ggatttttcc
     1861 ctaagcagag tttataccac aaagattctc caagtcctcc aaaacagcac agggacatca
     1921 gcctgtgcag agaccagggc cgaaggctga acttagaaag ctactattag gccatgtatt
     1981 gcacggcaat gcggtgtcgg aacaagatgt ttgaggtgct gaa
//
LOCUS       NM_001436966            4705 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 5, mRNA.
ACCESSION   NM_001436966 XM_063287911
VERSION     NM_001436966.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4705)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287911.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1520231.1,
                                           SRR26360194.149824.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000005.1  65211340-65211573   c
            235-439             JAXUCZ010000005.1  65207932-65208136   c
            440-753             JAXUCZ010000005.1  65204444-65204757   c
            754-874             JAXUCZ010000005.1  65202357-65202477   c
            875-1000            JAXUCZ010000005.1  65198348-65198473   c
            1001-1106           JAXUCZ010000005.1  65197553-65197658   c
            1107-1225           JAXUCZ010000005.1  65194234-65194352   c
            1226-1384           JAXUCZ010000005.1  65193640-65193798   c
            1385-1523           JAXUCZ010000005.1  65192934-65193072   c
            1524-1652           JAXUCZ010000005.1  65182204-65182332   c
            1653-1720           JAXUCZ010000005.1  65181732-65181799   c
            1721-4705           JAXUCZ010000005.1  65167375-65170359   c
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4705
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..234
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            235..439
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             275..1702
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform b is encoded by transcript variant 5;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform b"
                     /protein_id="NP_001423895.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSGSGKSGLWREQWTKSSSGYDKSRSLCPQHPQHIL
                     KLKNLPGSVYLSDPLPSFHTMSCSP"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     exon            440..753
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1000
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1106
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1225
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1523
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1652
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1720
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..4705
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcacgacg cctgccggaa gcgcgagcgg agaggcaccg gatgggtttc gcggtggaag
       61 gccggcgtct gcaagtccaa gctcagccgc ctcctccggc tttccactct gggaccttcc
      121 ggacggcgag ctaaattatc cgggctgcaa cgatcccgcc tcagctttgc acaggcccag
      181 cagtattttc ccggcggccc ctgcgccgac gactttggag acttccggag atagatactt
      241 gactgaaagg gatccatccc actgataaaa ccagatgcct tctcccactt cagcagacga
      301 agaggatggc ctggagacct gtgttttaaa gacttttgat ctggatttaa aagaatcaaa
      361 tattgttact ccaagcaata gtctcaaagc agagttagat ggcagtacaa agaagaaata
      421 ctcgtttgca aagaaaaagg cctttgccct ttttgtcaaa accaaacaag ttccagtgcc
      481 ttcttatgaa gttaaggaaa gacggtggcg atgttgtcag cagctgtttg cagagcagac
      541 cagcatccac agacatgtgg ccacacagca cgctgaagac gtgtaccagc agactgcttc
      601 cattctcaag cagctcactg cagcactgag gaccccacag agtcttacgc ccacagaccg
      661 gaggagctcc ccaaaagact gtctccctcc tagtcaggat gtgtctgctt ggctccctga
      721 tgtgagccac gttagcccgc aagagctgag gagtggccag ggcaatgagg aaggagaggt
      781 gctcctgtat tactgctact gtgacttgga ggaccccgac tgggtctgtg cctggcaggc
      841 agctctgtgc cgtcacctgc accttacagg caagattcgg atcgcgacag aaggaatcaa
      901 tggaaccgtt ggaggaagca aagtggccac ccgactctac atggaagtca tgctttcttg
      961 cccattattt aaggattacc tgagcgagga tgattttaag agcagcaaag gagggtctca
     1021 ctgcttcccg gaattgcgag tcggtgtgtt cgaagagatc gtgcccatgg ggatcagccc
     1081 cagtgaggtc tcctacaaga accccggaat ccatttatcc cctggagaat ttcataaaga
     1141 aatagaaaaa ctattgtcac aggcaaatca ggaacaaggt gatactctcc tactggactg
     1201 caggaacttc tatgaaagca aaataggacg attccagggc tgcttagcac cagacatcag
     1261 gaagttcagt tacttcccta gctacgttga caaaaacctt gacattttca ggcagaagag
     1321 ggtgctgatg tactgcactg ggggcattcg ctgcgaacgg ggttctgcat acctcagagc
     1381 caagggagtg tgtaaggaag tgtttcagct caagggtggc atccacaagt atctagaaga
     1441 gtttcctgat ggatttttca aagggaagct gtttgttttt gatgagcggt ttgccctggc
     1501 ctacaacagt gctgtggtct caggctctgg aaaaagtggc ctgtggcgtg agcagtggac
     1561 aaagagctct tcaggttatg ataagagcag gagtctgtgt ccccagcatc ctcagcacat
     1621 cctgaagttg aagaacttgc ctggaagtgt gtatttgtca gacccactgc cttcgtttca
     1681 caccatgtcc tgttctcctt agtagcatca ggaacacgtg acaaccaaga ccaaaagagt
     1741 tgcccccagg agaaatgagg aaaccacaga actcaaacaa gcaggagcta actccacagg
     1801 ataaagacag aaccacccag agaggaggag caacaggaag gagacttcaa agccaggtca
     1861 aatggaaaca ctgagggaga caggctgctc ctggtgaaca gcaccaccgt ttatgggatc
     1921 cgtgcactct gaactctacg tctcaggttc cttgacagaa cagctgaggc gacctgcagg
     1981 gcttggaagg aagctcgttt gttctgggtc taagaaagga caccctcaaa gccaaggcat
     2041 aaagctgatg ctgaggagag acccaacacg tggggacaca aagaagttgg cagagcacat
     2101 ggctagaaag aaagcaggca gtgttgatgg agggtctgcc cgggaacaca gtgggctctg
     2161 gggcatctgt catcagtgtc ctctgctctg cctagcaacg agtgggcagg tgctcactac
     2221 cctgtgtggg gaacgcacga gcagaccgct gcctgactca cctggttgtc gattttcagt
     2281 tcgaccagag aagtgttgtg ggggagagct tccaccaggc acaggatccc agctccggag
     2341 atgaagttgg actcgacatt cagcgtcttc aacaccttgt tcaccttcag catttcagca
     2401 agagccttga cggcaagaga aaagcagggc ctcctgaatg cccttgggca agggttgagc
     2461 agacccacaa ccacaccaag cagctcagcc ggacagtctc acgcactacc tttctaagcg
     2521 cgtctctgtc tctgctctcc tgcatcctgc gtggctcccc gacacccctg ctggagaatg
     2581 ctcatcagca ggcccgagtc tctgggccac gtctcctccc ctgggctgcc ttggctctct
     2641 gggtctactg catatacgca gagccttttc atttgaccac ttggaaggtt ccacttcacc
     2701 tgtcaagtct agttcatcct tcaaggccct tctcaacgcc tctcgctcca agagctttgc
     2761 tgacatctcc ggccacccag ggcctgttct ctggaacctt gcagaactta cccacaattc
     2821 cttcatggag cctacattcc tcaaatctct agttgttgtt cttgttgtgt gtgcatgcgt
     2881 gttcattcat acgcaggcgt gtgcatgtat tcgtattcct gtgttcgcat gttcactaag
     2941 gtacaggtat atgtatgtgt gtgcatgtgg cagtcagaag tcaactccaa cgtcatcttc
     3001 ataaacgcca tctactcccc ttgagacagc ctctctcact ggcctggaca gagctcatca
     3061 gctagtctag attgggtggt cagagggcct cagagcttgt cctgtgccca cctctccagc
     3121 actttggaga gccactctgc ccagtttttt acacagtgtt tgggactttg ctcaggttct
     3181 cgtgtttgta aggcaagtac cctaccgacg ggtatctcgg caacgttccc acgcccttcc
     3241 atttttctca ttggcgtgcc tccaccacca gactatctac gcttgtgggc tgaaaatgca
     3301 ccttaatgtc tgatattacc acagagtgcc cagcacatag tagggcatca agcagtgacc
     3361 actgaggccc ctggggagtc tccatctccc cgtgtatgtg ctcatctcgt ctcctctatg
     3421 ccacatggtc ttcctctgag ccccagagag tacagggcca gcctgcagag tagggctcag
     3481 atggccctca gcacgtttga gagggatctt gctgatgggg gtggggaagg ggagggtgta
     3541 gatgacaatc ggagcctctg aaggaaatga ggtaattagc agctggtgga aacgatgtgt
     3601 catggggaaa aacgatccca gcagctgaga ggcctgggac accgtgatgg ttgtgccagg
     3661 gtgtcagaag tgatgccagg aatggctgcc ctattgtgct cccccagctt gctgaaccct
     3721 gccagaggcc cagctcccag gaagccttca tgctgaaact ctctctctcc tttggctcct
     3781 tcattcgagc atgcccagag gtggtgtgtc agcttctcta tgacctgtgg ttgtctccaa
     3841 tctgtgtaag gtggcctctc agaggaatac ccctctccca ggaaaagtct ggtctgacca
     3901 ttaaccctgt ctgacagttc gcagacaggt gtaccaagcc ttgtacaggc tggtaactgg
     3961 acaggccctg gggtccggtt gtgccatgtg tcagatcctg tgtgttgggt cacactagag
     4021 gaacagaagg taggaggtag gtaccagggc aggcagtgtg tgtgggggaa ggggggactc
     4081 taagggctct ggcacctggt ctagcaacag gccagaaaca tttcagcact tggtaataag
     4141 tatgcaggta tgaagggcct gccatcagct gtcagcctgg catggagtcc gtgcctccaa
     4201 accttccgtg gcatggagct gagtgccagc ctgtcgagcc tggtttctga accatgaaca
     4261 agtagtacat ggggttttgc cagctatgtc actacagaca gaggcaggat tcactgaggt
     4321 cagacagagg tcatagatct agacattccc agactggcag gctatgaaat gcctttgtgg
     4381 acacacacac acacacacac acacacacac acacacacac acacacgtga gcccattcag
     4441 ttatttcatt ttaaaattgg gaagagctct attgctgctc ccattcctcc ttggaaagct
     4501 aattcctgcg tctcccctgc tccctgtggt agagcagcca ccccaggcta tacctctcag
     4561 ctgtcttcaa gacaagacag atgggtatga tcgtgaatgt gggatatgag gctagttaca
     4621 ggaaggttcc cagagtctaa ttcggtaaat tcagtattat gcatagactg ttggacgttt
     4681 aaaaaaaata aaagttactt tacaa
//
LOCUS       NM_001108359            4161 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 4 (Dcun1d4), transcript variant 1, mRNA.
ACCESSION   NM_001108359 XM_001068939 XM_341206
VERSION     NM_001108359.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4161)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001108359.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2194291.1,
                                           SRR26360190.3167530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000014.1  35077179-35077311   c
            134-204             JAXUCZ010000014.1  35057754-35057824   c
            205-244             JAXUCZ010000014.1  35057543-35057582   c
            245-359             JAXUCZ010000014.1  35049628-35049742   c
            360-451             JAXUCZ010000014.1  35047027-35047118   c
            452-522             JAXUCZ010000014.1  35037634-35037704   c
            523-614             JAXUCZ010000014.1  35034530-35034621   c
            615-723             JAXUCZ010000014.1  35024657-35024765   c
            724-828             JAXUCZ010000014.1  35012393-35012497   c
            829-931             JAXUCZ010000014.1  35010391-35010493   c
            932-4161            JAXUCZ010000014.1  35006799-35010028   c
FEATURES             Location/Qualifiers
     source          1..4161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4161
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="defective in cullin neddylation 1 domain containing
                     4"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
     exon            1..133
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..987
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DCN1-like protein 4; DCN1, defective in cullin neddylation
                     1, domain containing 4"
                     /codon_start=1
                     /product="DCN1-like protein 4 isoform 1"
                     /protein_id="NP_001101829.1"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
                     /translation="MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDVGQDDHQ
                     TGSLRSCSSSDCFSKVMPPRKKRRPASGDDLSAKKSRHDSMYRKYESTRIKTEEEAFS
                     SKRCLEWFYEYAGTEDAVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQE
                     WLKGMTSLQCDTTEKLRTTLDYLRSLLNDTTNFKLIYRYAFDFAREKDQRSLDINTAK
                     CMLGLLLGKIWPLFPVFHQFLEQSKYKVINKDQWCNVLEFSRTISLDLSNYDEDGAWP
                     VLLDEFVEWYKDKQMS"
     misc_feature    631..963
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    631..963
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     exon            134..204
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            205..244
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            245..359
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            360..451
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            452..522
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            523..614
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            615..723
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            724..828
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            829..931
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            932..4161
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaggagccg ccggtcctct gttgagagct aaggtttggg gagtcggtag ggggaccgcg
       61 agtggagcgc gggagcccgg gcggcaggcg ggtgtgagct gcccgaaaat gcactcggat
      121 gctgcagctg tcaactttca gctgaactct catctctcaa cactggcaaa cattcataag
      181 atctaccaca cccttaacaa gctaaatctg acagaagacg ttggccaaga cgatcaccaa
      241 acaggaagcc tgcggtcttg cagttcttcg gactgcttta gcaaagtgat gccgcccagg
      301 aaaaagagaa gacctgcctc tggagacgac ttatctgcca aaaaaagcag gcatgacagc
      361 atgtatagga aatacgagtc aactagaata aagactgaag aagaggcctt ctccagtaag
      421 cggtgcctgg agtggtttta tgaatatgca ggaactgagg atgcggtggg tcctgaaggc
      481 atggagaagt tctgtgaaga cattggtgtt gagccagaga acgtggttat gcttgtccta
      541 gcttggaaat tggatgcaca aaacatgggc tattttactc tgcaggaatg gctgaaagga
      601 atgacttccc tacaatgtga tacaacagaa aaactcagaa ctactttgga ttacttaaga
      661 tcattattaa acgatacaac aaactttaag ctcatttaca gatacgcgtt tgactttgca
      721 cgggaaaagg accagcgcag cctagacata aacactgcca agtgcatgtt gggactgtta
      781 ttaggaaaaa tctggcccct ttttccagtt tttcaccaat tcttagagca atcgaaatat
      841 aaagtgataa acaaagacca gtggtgcaat gtgctggagt tcagcaggac aataagtctc
      901 gacctcagca actacgatga agacggagca tggccagttt tgttggacga atttgtggaa
      961 tggtataaag acaagcagat gtcctaggac cttatgcata gcagcgcgag agtcactgtt
     1021 accacggtca tgtcacccat tagccataaa ctgctgtttg tatcgaagcg catgctgctt
     1081 ttcttgcact gtctgcctct cgcaggggtg tttggtgttt gctattggat gggccgctct
     1141 gcttgatgtg tagcattgtt ctcttggagg ctgctctgca gtccattttc acactacaga
     1201 ttggtgaatt gccaacgtcc tcactgtgat tatgtgtata ttgctgttta aatttgtata
     1261 tgtgtataaa atgaaaagct tcacctagag attatttctg caaaaatgta ttgtaaaaat
     1321 aattttgtgg catattttta gtccccccct ttttttttca aatgaaccag ttatacttta
     1381 tttggtctca aatgtagcat ttcagaaaac attacaactg tccccataag caagtattgc
     1441 cagaatcaac ctcactgctt aagaggccaa cttctggaag aagtaggagc cgtgactttc
     1501 tgtggcataa gctaaatatg acttggttcc cttggcaact ttgatatttt aaagtgacaa
     1561 aagttataat ttatttgagc gcacagacat atgacatgct acaaagcatt tctaacacaa
     1621 aaagtacagg tttatggggg tttttccttc ctcctcctct tcctcctcct taagttgctc
     1681 ctcatttaaa ttgaaaatta agtttccatc aatctttcac tgtttcccgc tttgtgttcc
     1741 tctagcagtg tttggtcagc tgaagctctc tgtgccactg tgagtaaaat gtcccatgag
     1801 cctcctggtt tgctggcggc ataagcactt tgaactatgg cttgagactt tagttcttct
     1861 tgtatggcgt ctgtagccca cgagggtttt ggagtttttt ggtttgtttg ttgttgttgt
     1921 tgttgttgtt gttttaaacc acaagtgaga agtgtttgtt ttctgtctgt ttcttctgtg
     1981 ctgggctttt cctggcaaca cgtccattgc aggcagtgga cttgaaacca ccagcattga
     2041 gctaaccctg ttcatattgg gacctttctc agaggggcca cttgtcattc ccggagtcac
     2101 atgtacagag ggtggtagcc attatgtgga tgagaaacca gagccaacac agtggtagtt
     2161 gtgcatttgt accttacgtc ttatttttag ggtttgtact tgctcgcctt gcccctcttg
     2221 cagaagctta cagttacaag tttttccaac tatttggtgc tatgactcac tcagtccctg
     2281 aagtttgtga acacgtctga gatttaaccc agtaaagagc catggcttgt ttgctgggta
     2341 aacggtgtag tgggataaga tccgtgcctg cccaggctgc tgatgactgg aggatattgg
     2401 gattatctgc caaaaagaaa aaaaaatgtc ctctacatta aatgtgaacc tttaaatggc
     2461 attaaatgat cagagcacac agacaatgct accccgacca ccgtcctata gttccttttc
     2521 agagtgttgc tattttcata tttctttccc tgattgaacc accaaagaca gaaatgttta
     2581 tgtatgtacc gtgtgcgtgc atatgcaaaa tcatggtgtg atagaatgtt tatgtatata
     2641 ccgtgtgcgt gcatatgcag aatcatggtg tggtagaagg caaatacttg ccttttccca
     2701 ccaaataatg cgatttggtt tgctgtgaaa aataaatcag aagtttgaaa aaccaacaaa
     2761 acaagccaac gtttcttcag catagttaat catcctttgt ccgcagtctc acagatttgt
     2821 atctgaacac aatgtagact tcttggaaaa ccacagctgt tgagactgct ctgtgaaagg
     2881 cattccagtg catatgggtg tgtgacagtg gggactgcta aagacaggca cggctctgtg
     2941 gagaagggtt ccttgtcggg tgtcccaagg ttacagaatc attctctcag ggcgctgttc
     3001 tggaggtaga tcaactgttg atcgcctcat tgcaaggatg gaccgtagat gggattgttt
     3061 taaacgctgt gtgggaatgg agagaatgtt ttaaacacta agcacagtgg atctgtgaat
     3121 aaagggttgt taccagggtg agaaattcca tttcatctac agtgagcatt ttggtaatag
     3181 tgactcaagt aagaaccacc atgatgtata cggtatggaa gttcgaattc tggaggggat
     3241 aaccaatatt tagaactcca gataatgtct ggactgcctg aagaaacaaa ccactgtgac
     3301 gtggcttgcc tttggatttc tcgattttac agagctattt ttaagggagt cagacacagt
     3361 aataagacac cttttcttga agaatcgcca agttacgcaa gttgaacgat caccaagagc
     3421 acttatggcc agcgtaggaa gaagccaggg cgccttcggt tctccagtac ctgagctcca
     3481 gccacccttc ctcccttcac ctgtgtttca gggcgctgcg actcgtcttg ttggggtacg
     3541 cgacttgtag acatttccac tgcactaggt agaagttacg tggcaagatt tgctggatac
     3601 ccattgtagc cttaggtgcg cctcttttga agcctgaact cttgagttca gtattgatat
     3661 ctgattagac aaacctctag attctggttt aacagatttc tgttgcctct aagtctccat
     3721 cctaaccata cttttgaagt ttatacagaa agctttaaga gtttagtttg tgtccttggt
     3781 ttttattttt acaactgcta aaatacctct gtaagcctta tcctttattc tttcatagtt
     3841 gtataaaatt gtatagaatt cattgaccaa ctgaaatgtt gggtatctgt aaatgagacc
     3901 aaaatgtggt tgcttttttc cataaactga tttccattgg gcgctgctgt gatgtgagca
     3961 gcagccagcc tgtgactgtg aatgcctcgt gtcgtcagta tttgcattac attcatacaa
     4021 gtgtgcaagt cctgtgactc ccagcttaac taaaatactg tcatgccatt taatgagcac
     4081 agaaaactgg tttaggtttt aatggagttg atgtaaaatg atagcccata aataaacaga
     4141 tatttgtgtt tggtttccga a
//
LOCUS       NM_001436967            8122 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 6, mRNA.
ACCESSION   NM_001436967 XM_063287910
VERSION     NM_001436967.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8122)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287910.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2251424.1,
                                           SRR26360190.72806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000005.1  65211340-65211573   c
            235-439             JAXUCZ010000005.1  65207932-65208136   c
            440-753             JAXUCZ010000005.1  65204444-65204757   c
            754-874             JAXUCZ010000005.1  65202357-65202477   c
            875-1000            JAXUCZ010000005.1  65198348-65198473   c
            1001-1106           JAXUCZ010000005.1  65197553-65197658   c
            1107-1225           JAXUCZ010000005.1  65194234-65194352   c
            1226-1384           JAXUCZ010000005.1  65193640-65193798   c
            1385-1523           JAXUCZ010000005.1  65192934-65193072   c
            1524-1652           JAXUCZ010000005.1  65182204-65182332   c
            1653-8122           JAXUCZ010000005.1  65175330-65181799   c
FEATURES             Location/Qualifiers
     source          1..8122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..8122
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..234
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            235..439
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             275..1702
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform b is encoded by transcript variant 6;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform b"
                     /protein_id="NP_001423896.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSGSGKSGLWREQWTKSSSGYDKSRSLCPQHPQHIL
                     KLKNLPGSVYLSDPLPSFHTMSCSP"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     exon            440..753
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1000
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1106
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1225
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1523
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1652
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..8122
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcacgacg cctgccggaa gcgcgagcgg agaggcaccg gatgggtttc gcggtggaag
       61 gccggcgtct gcaagtccaa gctcagccgc ctcctccggc tttccactct gggaccttcc
      121 ggacggcgag ctaaattatc cgggctgcaa cgatcccgcc tcagctttgc acaggcccag
      181 cagtattttc ccggcggccc ctgcgccgac gactttggag acttccggag atagatactt
      241 gactgaaagg gatccatccc actgataaaa ccagatgcct tctcccactt cagcagacga
      301 agaggatggc ctggagacct gtgttttaaa gacttttgat ctggatttaa aagaatcaaa
      361 tattgttact ccaagcaata gtctcaaagc agagttagat ggcagtacaa agaagaaata
      421 ctcgtttgca aagaaaaagg cctttgccct ttttgtcaaa accaaacaag ttccagtgcc
      481 ttcttatgaa gttaaggaaa gacggtggcg atgttgtcag cagctgtttg cagagcagac
      541 cagcatccac agacatgtgg ccacacagca cgctgaagac gtgtaccagc agactgcttc
      601 cattctcaag cagctcactg cagcactgag gaccccacag agtcttacgc ccacagaccg
      661 gaggagctcc ccaaaagact gtctccctcc tagtcaggat gtgtctgctt ggctccctga
      721 tgtgagccac gttagcccgc aagagctgag gagtggccag ggcaatgagg aaggagaggt
      781 gctcctgtat tactgctact gtgacttgga ggaccccgac tgggtctgtg cctggcaggc
      841 agctctgtgc cgtcacctgc accttacagg caagattcgg atcgcgacag aaggaatcaa
      901 tggaaccgtt ggaggaagca aagtggccac ccgactctac atggaagtca tgctttcttg
      961 cccattattt aaggattacc tgagcgagga tgattttaag agcagcaaag gagggtctca
     1021 ctgcttcccg gaattgcgag tcggtgtgtt cgaagagatc gtgcccatgg ggatcagccc
     1081 cagtgaggtc tcctacaaga accccggaat ccatttatcc cctggagaat ttcataaaga
     1141 aatagaaaaa ctattgtcac aggcaaatca ggaacaaggt gatactctcc tactggactg
     1201 caggaacttc tatgaaagca aaataggacg attccagggc tgcttagcac cagacatcag
     1261 gaagttcagt tacttcccta gctacgttga caaaaacctt gacattttca ggcagaagag
     1321 ggtgctgatg tactgcactg ggggcattcg ctgcgaacgg ggttctgcat acctcagagc
     1381 caagggagtg tgtaaggaag tgtttcagct caagggtggc atccacaagt atctagaaga
     1441 gtttcctgat ggatttttca aagggaagct gtttgttttt gatgagcggt ttgccctggc
     1501 ctacaacagt gctgtggtct caggctctgg aaaaagtggc ctgtggcgtg agcagtggac
     1561 aaagagctct tcaggttatg ataagagcag gagtctgtgt ccccagcatc ctcagcacat
     1621 cctgaagttg aagaacttgc ctggaagtgt gtatttgtca gacccactgc cttcgtttca
     1681 caccatgtcc tgttctcctt agtagcatca ggaacacgtg gtaagtgact ccacctggga
     1741 ctcgtgagca gttagcacgt gggaacaggt gggggaccca tgttgccttt cattctgaga
     1801 actatgcgcg tgcttgatga agaggacaga ctttttccct ctttgtggaa aaggagtcaa
     1861 aggatgccct gaacagacac tgaggggatg tgacttactt tcacgtttta tttttattat
     1921 tagtgttaca tgtgcatgtg gaggtcaaag ggcaacttta tgggttctag ggattgaact
     1981 cagttcacca aagcatattc agtgagcgca ttcactcacc gagccatctt gcttgctctg
     2041 catttacttt tctatgaact acacatttct gactttccct tgggagccac atggagtctc
     2101 ctgggcagtg gcatttgatg atggtgttgg cttttggtga tggcattagc tgagagcttt
     2161 gggaaatcag tgtgacctag agaagggtct tctaaagagg agcagaccct agattagcct
     2221 gtgcacccca acatttcatt tcctctagct gacatgctga actcttggcc cagtcagtgc
     2281 tgagctgggc taggaaggag aggccttttc tcttggtcct gaaggcaggc agctcacaga
     2341 cttgggggga gggggagatg tgttttaaca cagaacaaga tgtgataccc atgaaagtca
     2401 ggagtgtgac cccgtaaacc tctcctggag tgcggtgggt agataagatg gcagaataca
     2461 ggcatgtact caccaaggtc gttgttgttc atcatggcgt tggatgcccg cagccggggc
     2521 ccctgctggg taaagtggta gccaaatttg aggagtgttg tgtttttctc caacatgttc
     2581 acgatctcca tttccacttt gttgcccaaa ggctggctct ttggtttttt gaaaaaaaga
     2641 aaaacaaatc agtaattaca caagtgcttt tacctaagct acctctccac atggaagccc
     2701 tcagtgtttg tgtgcagagt gttacctgct ctcaaagagt gaagctgtgc agagaagccg
     2761 acataaaaag aaagctggtg tcattcagca tgcttaaagg caggacgatt tccccagttc
     2821 cccagaagca ggaaaatgcc accatgccta cttttaacag aactgctcta gaggtcctgg
     2881 ccagaaaact gagcaagaaa agaaagacat ctaagctaaa gacgagggca cctattagga
     2941 tcatctaatc ttggatctag agaatcccaa tacacacaca cacagacaca cacacacaca
     3001 cacacacact catacacaca cagacataca cattcataca cacatacact catacacaca
     3061 cacactcata cacacacaca ctcatacaca cacagacata cacattcata cacacacaca
     3121 ctcatacaca cacacataca cattcataca cacattcact catacacaca cacatacact
     3181 cacacacaca ttcacacata cacacactca tacacataca cactcataca cacacataca
     3241 cacactcata cacatacact cacacacata cacacataca cacacactca tacacacaca
     3301 ctcatacaca cacatacaca cactcataca catacactca cacacataca cacacacata
     3361 cacacactca cacatacaca catacatata cacactacat acacatacac acacactcac
     3421 acacacatac acacacacat atgcacgcgt gcgccaattt gtttcatcaa gcatatagaa
     3481 aataaaagca acaaataaaa cacatctgca tgtcaagtat taattcaaga aaaaaactac
     3541 aagacagcat tgagtgccat caaaggacac ctatgaatta acctatgaag tataaagcca
     3601 gcagcccatg cccacgggcc agaaatctgc tactgctaat gaggtgatgc caaactgatc
     3661 catggtatca gtggggtctt ttattaaaat ttccacattc atttttctta tccctcaaaa
     3721 atggacaagg tgatctagaa atctcatgtc aatgcaagtg atcttaaaac agtgtgagga
     3781 ctcaaacact tctgatttca aagttaacta tcaaatctgt ggtagacttt gtaatgctgg
     3841 ggtaaggcag acatgagact gaaggaaaca gaagcgagtc cagccgtgag cctgtacatc
     3901 tcttcagatg gctttacaag ggggagctga gaaaacagaa tgaagccatg tggtggcaca
     3961 agcaaaagaa cggatttagc cccttgactc accaatacat caatatcaat tcacaatgtt
     4021 tccgagaggg ctgaggcagt gactcagtgc ataagtgtgc ttgctgtaca ggcaaaaagg
     4081 gactgagtgc agatcccagc accctgaaac agccagccat gaccatgtgt gtctgtaact
     4141 ccagtgctgc gtgctgagtg gagaccggaa gagctctccc gtctcaaagg aataaagaag
     4201 gtaaaggaca cccaaaggcc tcctctggcc tgcggatcaa agatctaacg ataagaacta
     4261 atgctatgat accctcaaaa catttgttca aacgtttgtg accttagcaa tggttcgtta
     4321 ggtacgacag ctatagcaca aacatcagaa ggagaaaatg aattagtgtt atgctaatag
     4381 aacactacca aagaagttcc catctacgct catgcaagca actctaatta aacccagtgg
     4441 gtgacactct gaaagacgac atgaaggtag gagggtgaca tgttggaaag aagacatatt
     4501 ccagtggaag acagaggggg acgagctagc agggagatgt gaaaactatt cattataaac
     4561 atatacacgg ctgtcaaata atttaagaat gggtggtggt ggtagtggtg gtggcaaaaa
     4621 gacaggccag gaagatgacc ccatgtaaag tttttactgc atcagcatga gttcaggtgc
     4681 ccggctctga tgtcaaggcc acacacagca aggagcatgc tcagaaccca cgtgctgagg
     4741 ggcagaaact ggcagaccct gaaagttcac aggccagcca ctctagccaa agtgaggttt
     4801 acagattcaa caggaaaacc tgtctcaaaa gatacagggc aatagagaga gctgttgttg
     4861 acctctgggt tcacacatga gtgcacagca catgtacttt catatacaca cccacacata
     4921 tatcacacac acacacatgc atcacacaca cacatgcaca tacatcacac acgcaccaca
     4981 cacacacatg ccacacacat gcatcacaca caaacacacc cacatgcaca cacacacatg
     5041 catcacacac aaacataccc acacacatgc atcacacaca catgcatcac acacacacca
     5101 cacacacaca catacatcac acacacacat gcatcacaca cacatgcatc acacacacac
     5161 accacacaca caccatacac aaacacacac atatatcaca cacatacatc acacataaac
     5221 atacccacat gcacacaccc acacacacgc atcacacaca catgcatcac acacacacca
     5281 cacacacata catcacacac acacatgcat cacacacaca catacatcat acacatacat
     5341 gcatcacaca tacaccacac acacatacat cacacacata catcacacac acatgcatca
     5401 cacacacatg catcacacac acacatacat cacacacaaa cacaccccca cacccacaca
     5461 cacacataca tcacacacac atgcatcaca cacacatgca tcacgcacac acaccacaca
     5521 cacatacatc acacacacat gcatcgcaca cacacataca tcatacacat acatgcatca
     5581 cacatacacc acacacacat acatcacaca cacatgcatc acacacacac atacatcaca
     5641 cacaaacaca cccccacacc ctcacacaca catacatcac acacacacat gcatcacaca
     5701 cacaccatac acaaacacac acatatatca cacacataca tcacacataa acatacccac
     5761 atgcacacac ccacacacac gcatcacaca cacatgcatc acacacacac cacacacaca
     5821 tacatcacac acacacatgc atcacacaca cacatacatc atacacatac atgcatcaca
     5881 catacaccac acacacatac atcacacaca catacatcac acacacatgc atcacacaca
     5941 catacatcac acacccccac acccccacac ccacacacac acacatacat cacacacaca
     6001 catgcatcac acacaaacac acccccacac acacaccaca cacatacatc acacacacat
     6061 gcatcacaca cacacacaca cacaccacac atacatcaca cacacatgca tcacacacac
     6121 acacacacac acacacacac gaatgcaccg gagtggaaag gataacatgg aatggagaag
     6181 gttgtaaagg tatagtatat ctggtaaggg ctagtatata aagatgcaaa taaataaatt
     6241 agaaatagac aaagcatttg aacagaaatt ccgtaaagta gatgtatgag gggctgagag
     6301 aaggctcagt ggttaagagc actggctacc cttccagagg acctgggctc aatatccagc
     6361 acccacacgg tgtctcacaa actctggaac tccagttcca ggggatcaaa tgcctccacg
     6421 ggcaccaggt atgcataagt gtatagacct atacattgag agttcatgca gtgaagaact
     6481 gtccaatgag ggaagattcc ctaagtggaa ggtagctgcc tctctctaga gtcttcctta
     6541 acatcattag tagggaaggc tggggcttca tgatctctag acgtcatggg ctgtgggctg
     6601 tgaccctgtg agtaacttgc ttgggtggaa taaaaagagt ggacaaaaga cagcaagaag
     6661 ccccgagcga gagggctggg ctgagctggg ctgggcgggg actaaactgg cagagttcgg
     6721 tcagtgaaga actctggcct cctttcagat ttactggggg attagataaa tcccttgtgg
     6781 ataaattaat ctaagttttc acatcaaatg attggatgga gagaagcaga gccttccttc
     6841 atatcgcccc cctttctatc tcccctgtcc atggatgtac cccaccccca tgcccatggc
     6901 tgcaccccct gcccccatgc ccatggctgc accccctgct cccatgccca tggctgcacc
     6961 ccctgctccc atgcccatgg cttcacttct gggcataaaa tccagggcag aaatagacag
     7021 ggctggcctg ttttgttgcc ttttccccct aaatagattt atatcatatt tattttctgc
     7081 aacttcccat tctgtttact attttgcaga aaattcccaa gctagtactg gagaaccacc
     7141 accttgtttt ttttgtttgt ttgtttgttt tttgtttttt tttgtttttg tttttttttg
     7201 tttttgtttt aaactgcttc ttggggtgcc cctgagatgc tgcagtgcag acagctgtct
     7261 gcatccacac ctcgtcccac acaaggcagt gcagtggact ctgccggaga agagagatta
     7321 ttctacagtt gactagtgtt gggttgagag agaagcacac ttcggtggta gcagcttatg
     7381 tcctcgcctg cttacagcga ctgagggttt tcagtttgat gagattgtga caaaagcctc
     7441 aggtgttgag gtctatgatg agggcctggt ggctgtgacc ctggatgtca gaccattcct
     7501 tcgctcattt gacagtccac tttatcgtga cctagaggac atgtgcagct ggagcaccga
     7561 aaatacatcc tcgtgccagg tgcggtgtca cacaccttta atcccagcac gagcagatct
     7621 ctgtgagttc aaggccagcg tgctctacat agtgaattcc agaacagcca aaactatata
     7681 gtgagactat atatacttag tctcaaaaaa aaaaaaaaaa aaaagaagaa gaaagaaaag
     7741 aaagaagaga catcagccag gtatcctgga agtacttggc caacaccagg gccatatgcc
     7801 acctctcact ggcataagca tcactctgtt tgcaagctgc caattctgct ctgccgacac
     7861 accactgggg aagaagctca ccacctgagg gacacctgct ttgtcctggg gtagcgctgc
     7921 tgattagaaa ggccttcctc accaaagtgc tacaacgtag aagagtacag gggacgagta
     7981 tggcagtgat ttaaggtagt ctgcatcgag gagtggagag ggataactga cttgaagtat
     8041 attttgaaaa aaagaaatca catgagaatg cttgccccag acgccatagg ttgctgaata
     8101 aaaatcccag tgccagatat ga
//
LOCUS       NM_001436968            2568 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 7, mRNA.
ACCESSION   NM_001436968 XM_006238090
VERSION     NM_001436968.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006238090.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1176755.1,
                                           SRR26360176.1415762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000005.1  65211224-65211292   c
            70-274              JAXUCZ010000005.1  65207932-65208136   c
            275-588             JAXUCZ010000005.1  65204444-65204757   c
            589-709             JAXUCZ010000005.1  65202357-65202477   c
            710-835             JAXUCZ010000005.1  65198348-65198473   c
            836-941             JAXUCZ010000005.1  65197553-65197658   c
            942-1060            JAXUCZ010000005.1  65194234-65194352   c
            1061-1219           JAXUCZ010000005.1  65193640-65193798   c
            1220-1358           JAXUCZ010000005.1  65192934-65193072   c
            1359-1487           JAXUCZ010000005.1  65182204-65182332   c
            1488-1555           JAXUCZ010000005.1  65181732-65181799   c
            1556-2568           JAXUCZ010000005.1  65175330-65176342   c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2568
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..69
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            70..274
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             110..1537
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform b is encoded by transcript variant 7;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform b"
                     /protein_id="NP_001423897.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSGSGKSGLWREQWTKSSSGYDKSRSLCPQHPQHIL
                     KLKNLPGSVYLSDPLPSFHTMSCSP"
     misc_feature    614..>1324
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     misc_feature    614..>1324
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     exon            275..588
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            589..709
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            710..835
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            836..941
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1060
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1358
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1487
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1555
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..2568
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggctcca gggcggggag cagcgccaag ttggagaagg gagacccagg aaaggcctag
       61 gtattgcgga tacttgactg aaagggatcc atcccactga taaaaccaga tgccttctcc
      121 cacttcagca gacgaagagg atggcctgga gacctgtgtt ttaaagactt ttgatctgga
      181 tttaaaagaa tcaaatattg ttactccaag caatagtctc aaagcagagt tagatggcag
      241 tacaaagaag aaatactcgt ttgcaaagaa aaaggccttt gccctttttg tcaaaaccaa
      301 acaagttcca gtgccttctt atgaagttaa ggaaagacgg tggcgatgtt gtcagcagct
      361 gtttgcagag cagaccagca tccacagaca tgtggccaca cagcacgctg aagacgtgta
      421 ccagcagact gcttccattc tcaagcagct cactgcagca ctgaggaccc cacagagtct
      481 tacgcccaca gaccggagga gctccccaaa agactgtctc cctcctagtc aggatgtgtc
      541 tgcttggctc cctgatgtga gccacgttag cccgcaagag ctgaggagtg gccagggcaa
      601 tgaggaagga gaggtgctcc tgtattactg ctactgtgac ttggaggacc ccgactgggt
      661 ctgtgcctgg caggcagctc tgtgccgtca cctgcacctt acaggcaaga ttcggatcgc
      721 gacagaagga atcaatggaa ccgttggagg aagcaaagtg gccacccgac tctacatgga
      781 agtcatgctt tcttgcccat tatttaagga ttacctgagc gaggatgatt ttaagagcag
      841 caaaggaggg tctcactgct tcccggaatt gcgagtcggt gtgttcgaag agatcgtgcc
      901 catggggatc agccccagtg aggtctccta caagaacccc ggaatccatt tatcccctgg
      961 agaatttcat aaagaaatag aaaaactatt gtcacaggca aatcaggaac aaggtgatac
     1021 tctcctactg gactgcagga acttctatga aagcaaaata ggacgattcc agggctgctt
     1081 agcaccagac atcaggaagt tcagttactt ccctagctac gttgacaaaa accttgacat
     1141 tttcaggcag aagagggtgc tgatgtactg cactgggggc attcgctgcg aacggggttc
     1201 tgcatacctc agagccaagg gagtgtgtaa ggaagtgttt cagctcaagg gtggcatcca
     1261 caagtatcta gaagagtttc ctgatggatt tttcaaaggg aagctgtttg tttttgatga
     1321 gcggtttgcc ctggcctaca acagtgctgt ggtctcaggc tctggaaaaa gtggcctgtg
     1381 gcgtgagcag tggacaaaga gctcttcagg ttatgataag agcaggagtc tgtgtcccca
     1441 gcatcctcag cacatcctga agttgaagaa cttgcctgga agtgtgtatt tgtcagaccc
     1501 actgccttcg tttcacacca tgtcctgttc tccttagtag catcaggaac acgtgaaaat
     1561 tcccaagcta gtactggaga accaccacct tgtttttttt gtttgtttgt ttgttttttg
     1621 tttttttttg tttttgtttt tttttgtttt tgttttaaac tgcttcttgg ggtgcccctg
     1681 agatgctgca gtgcagacag ctgtctgcat ccacacctcg tcccacacaa ggcagtgcag
     1741 tggactctgc cggagaagag agattattct acagttgact agtgttgggt tgagagagaa
     1801 gcacacttcg gtggtagcag cttatgtcct cgcctgctta cagcgactga gggttttcag
     1861 tttgatgaga ttgtgacaaa agcctcaggt gttgaggtct atgatgaggg cctggtggct
     1921 gtgaccctgg atgtcagacc attccttcgc tcatttgaca gtccacttta tcgtgaccta
     1981 gaggacatgt gcagctggag caccgaaaat acatcctcgt gccaggtgcg gtgtcacaca
     2041 cctttaatcc cagcacgagc agatctctgt gagttcaagg ccagcgtgct ctacatagtg
     2101 aattccagaa cagccaaaac tatatagtga gactatatat acttagtctc aaaaaaaaaa
     2161 aaaaaaaaaa gaagaagaaa gaaaagaaag aagagacatc agccaggtat cctggaagta
     2221 cttggccaac accagggcca tatgccacct ctcactggca taagcatcac tctgtttgca
     2281 agctgccaat tctgctctgc cgacacacca ctggggaaga agctcaccac ctgagggaca
     2341 cctgctttgt cctggggtag cgctgctgat tagaaaggcc ttcctcacca aagtgctaca
     2401 acgtagaaga gtacagggga cgagtatggc agtgatttaa ggtagtctgc atcgaggagt
     2461 ggagagggat aactgacttg aagtatattt tgaaaaaaag aaatcacatg agaatgcttg
     2521 ccccagacgc cataggttgc tgaataaaaa tcccagtgcc agatatga
//
LOCUS       NM_001437005            5979 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 3, mRNA.
ACCESSION   NM_001437005 XM_063287921
VERSION     NM_001437005.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5979)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5979)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5979)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5979)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5979)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5979)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5979)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5979)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5979)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5979)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287921.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18996.1,
                                           SRR26643287.13259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000005.1  73135386-73135393
            9-218               JAXUCZ010000005.1  73140265-73140474
            219-421             JAXUCZ010000005.1  73142997-73143199
            422-481             JAXUCZ010000005.1  73151592-73151651
            482-685             JAXUCZ010000005.1  73152711-73152914
            686-963             JAXUCZ010000005.1  73158194-73158471
            964-1096            JAXUCZ010000005.1  73160426-73160558
            1097-1226           JAXUCZ010000005.1  73165478-73165607
            1227-1360           JAXUCZ010000005.1  73169494-73169627
            1361-1488           JAXUCZ010000005.1  73170920-73171047
            1489-5979           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5979
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..8
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            9..218
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    200..202
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            219..421
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1702
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 3;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423934.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    317..1150
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    317..1150
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1181..>1297
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1181..>1297
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            422..481
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            482..685
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            686..963
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1096
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1226
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1360
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1488
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..5979
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttagat tcagattgtg tgtgtggatt gtttcaaagc tccgcacaaa gacttaggac
       61 tttaattaaa atggcagagt gaaaatactt gtactttatt caatctgaag ttaccctgaa
      121 aaaaacatga aaaatggaag atggatctta acacagcttc cccaacgcaa atattgctgt
      181 gaccccaaac tgaaatgttt gagaggtggt tgccacagaa gtacctctgt tgacaggaaa
      241 caagattctg tttcataaag aagatgaaaa caactgggtt cctgttaaca aacacccaag
      301 agaccagcat agaccaatga gcagagtcaa taagaacgtg gtcttggccc ttctaacact
      361 gatgagctgt gccttcctgc tgtttcagct gtactactac aagcactact tgtcagcacg
      421 gaatggaacg ggttcatcaa aatccaaagg aaatcgagtt ggatttgata gcacacaatg
      481 gcgtgcagtt aagaaattta ttatgctgac atccagccaa aatgtgccgg tgttccttat
      541 tgacccttgg attctggaat caattaataa aaatttcgaa caagtgaaaa atgcctctca
      601 aggctcggcc tcagaatgca gatttttctg tgttccgaga gacttcactg cgttcgcgct
      661 gcagtatcac ctgtggaaga atgaggatgg atggtttcag atggctgaga acatgggatt
      721 ccagtgcctg aagattgaaa gcaaagatcc tcggctggat ggaatagact cgctttccgg
      781 aactgagatc cctctgcact atgtctgtaa gctggccact cacgccatcc acttggtcgt
      841 ctttcacgag aggagtggca actacctctg gcatggtcac ctacgactca aagggcacat
      901 ggataggaag tttgttcctt ttcgaaggct acaatttggt cgttatcctg gagcctttga
      961 caggccggag ttacagcagg ttactgttga tggactcgac atgcttattc caaaagaccc
     1021 agggcgcttt ctagaagaag tacctcactc cagatttatc gagtgcaggt ataaagaagc
     1081 ccgggcattc cttcagcagt acgtcgatga caacactgtg gatgccatgg cctttcggaa
     1141 gagggcaaag gagttactgc aactagcggc caagacgctg aaggcgctgg gagtgccctt
     1201 ctggctgagc agtgggacgt gtctaggatg gtatcggcaa tgcagtatca ttccttatag
     1261 caaagatgtc gacctaggaa ttttcattca agattacaaa cctgatattg ttttggcatt
     1321 tcaggatgca ggacttccac tcaaacacaa gtttgggaag gtggaggaca gcttggaact
     1381 ctccttccag ggacaagctg atgtaaaact tgatattttt ttcttctatg aagagactga
     1441 ccatatgtgg aatggaggca cgcaggccag aacaggaaag aagtttaagt atctgttccc
     1501 caagtttaca ctgtgctgga cggagtttgt agacataaaa gtccatgttc cctgtgaaac
     1561 agttgactac attgaagcca actatggcaa ggcctggaag atccctgtca agacctggga
     1621 ctggaagagc tcacccccga atgtgcagcc caatggggtc tggcctattt cggagtggga
     1681 tgaagttatc cagttgtact gagaacactg agctcatgtg ggacgtttcc cagaaagaag
     1741 gtaggcagct gttgaaagca ctatgttttc tgcctgatgt gagagccaaa gaggagaaat
     1801 gacgagttgg aagacagaaa aggttttctg actcatgggc catctaatca gttctgccac
     1861 tcagcattta ctgaggagtt tatacaccag gtgaagtact aggatctggt gaacaggcag
     1921 agaggaatga gaggccagct tctctcttgc cctgttggta agcactacaa ttttatgtta
     1981 agggaaacta acccactctc tgaagaggtg tacagtagaa tgtattccat aatgattttt
     2041 aaaatgttaa ttaatgttta aaccggaaag tgagctcatc agacaaagct aacaaaggat
     2101 gtgttagttg agagtagttc atttctgcct gccctcggga tttaagctgc tgtgttagtg
     2161 ttaaggttgt gggatatgag ttaatattcc agtgagtgat tagactttgt ctcacagaga
     2221 aaagacagtg gccaactcat tttacaagca gtgtgataca cagttgactt caagcactgg
     2281 gcattctata agggaggatg agagccgata gcagctcttg tcaagacgta cactgttttc
     2341 atctttgaga tgaacatgga tgcttagatg gtgcttgaat ccctgacatc ataaggatat
     2401 tttcactgac ctgcagtagt acttcctgat aaatcattca gtcgtgctat ccaaaagttg
     2461 tgacatctca aagcttccgt tccttatttc attcttagtc actcttaaac tcaaaaatgg
     2521 aagttactca tgaatatttt tatattttat gaatgtataa cttttctgcc tttaatttta
     2581 atattgacac taagtaataa tagacatacc tcttaatttt ttaaaaatac cctttattta
     2641 tttatcaacc atagttccat gtgtttaatt tatggcctac acactaattt atttagcaca
     2701 agatatgcct gttcttctat ccaatattac ttcacggttc caaaatgaag ggttaacgtg
     2761 aacctggcca ttactccttt tcccagatta ctgtctttaa agcctgtgtc catctctaga
     2821 ttttcattct gctgagtgta atagggcaag ggcttcctac ccacaagtac tgcacaagtg
     2881 ggacccttga cctacactcc tgagtccatt gtagtggctg cacataagcc atgcagtctc
     2941 agagagagat gacacagtga gtgcctgcct gccttgcctg ggaggggagg gtccactccc
     3001 tgctgcttag ggatgtgctt catggcaacc tggcagattt cccttggcac gtgtagttac
     3061 tacagcagaa accaggatag atgagagaat gggctggcag aaagaaaaga aaaaagaaag
     3121 aaaaagaaaa acttggagga agtaacttga agccacctat ttccaaattt aaacttcaac
     3181 atgaaaactg tctttgttgg atgatatgca gcagtctcca tgcagcctcc aagtaggaat
     3241 attgtctctc cataagcatc atctaatcag agtgttacag ttattagcac acatgtaccc
     3301 aaatgacaaa tcataatcag ctctttccta gaaaataagt ccatagaata cgtacccaag
     3361 ttgtagatac ccaaccctac atatttttct gtgtgcgcat gcgtgtgcac gcacacaccc
     3421 ccactcgcac acaccagata atagtgtttt tgaggacaaa cccaccctac ctggagagga
     3481 tcatttactt gtactcaata tcaagaagta tgtttatatc gtgttccttg agagctccca
     3541 ccttctgcca ggagatctta cccacccctg tttaagtttc ttctctcata cctgtcgttg
     3601 gagtgcaagg tctgccagtg tccataatac aagctcttgg tcctgggcac agaggttctg
     3661 tagtcttccc ttcatagagg atgggtacct gttttccctc tggtttggct ttaggtttta
     3721 ggttccgccc accgtggaga aattttccca gaatttgcag gtgaggttta cctctaaaaa
     3781 tgactccatg attcagtcat actgaagtca gtgcttctta actcttgaac tctgctgagt
     3841 gtcccgagat cttgggtcag gtctgcccac cacctgaacc ttttcagatc acttctcttc
     3901 cctccctgaa tatgctaact gttattctcc taatatgagt gctttctggt cccatttgcc
     3961 tggactgctt gaagatacct ttacattaac tcattggtag ttctgctgcc gaggatcttt
     4021 cagagggacc ctgagaagca gatgctttct cggtttacga cagccatcta cttccctaag
     4081 cgtggaggac ttgccccgct cttggttaca gttactgaca ttggccactg agatgaaata
     4141 atagtaacta aaactggcct ccctgagagt acctgagatc cgttcttagt gtggcctcca
     4201 tgacactcca gtgcttggtg agtcctccag tgcctcagtg cctgccattc cccacggaag
     4261 gcctgaggcg acagaaaatg ctgaggaggg atgtttcctc ttgtccagaa ttctcaggct
     4321 accgtctcac ctttgtctgg ggagggttca ggaggtgggc caagggaggg gaagccttat
     4381 ctacaaaaaa tagaacagtt tatgtctgaa gacatcacca gaagtcagtt tctgactctt
     4441 gaaatgttta aaggatttaa tgatgcatac agtgcttcca ttcaggccca gcgttaagta
     4501 agtactcgcc atttcctagt tctcggttcc tttgtaacgt ggaaggctgc acgacagagt
     4561 tgcttagaac taaaattggg gcactgctga gatggcttag caggcaaaag cccttgtcac
     4621 caaaagtgac atgagtttga ttcccaggac ccatgtaatg gaaggaaaga atctcaaatt
     4681 gcttgtcatc caatacacag actctgatgt gcttggagct cctctctagc atgagaggac
     4741 accacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     4801 cactaagtaa atataatgga aagtttttat tttatctaag cattacaggt cgaattatgt
     4861 gatttttgag tcattgccat attccctcca cctgaaacag agctggttct cacttagttg
     4921 accaagtggt tgtcttctaa tcctatccta ttgtactata ccctttaagc acagtcagat
     4981 tgctcttaag ttttgtgcct tgattttcaa tagtccagct ttgggcagct aacatcacta
     5041 tatataatga tttggagaac caaagatttt ggaatgctta gttttattta cctgcctagt
     5101 ctgtatagaa atgtgggcta gttagtctaa ttgcccagca tgtgtgaggt ctggattcag
     5161 tacaaagcac cagaagtctg agacagaaga cttagcacat gctgaaggcc agcttgggct
     5221 acctagtgag taccagccta tcctgggcta cagtgtaaga ccctatattg attgaggaca
     5281 caggagggaa gagagaaaca gagacagaat gagaatatac tcctgtcagc catctgccca
     5341 tagatgtatg ttttaatcta agcgaggcaa aatcaggata tatagtgtgg atttttaaat
     5401 agttaattgt agacaattaa cagccaattc gatattgatg ctttttgtat aggaccaata
     5461 ggcaagtgta atgtgttgag aaacgtattt ccaaacactc agaacaccta ggctaaagcc
     5521 tgctcctgta actcctggac ctaacgtaga aggatcgaag aatctctgtg agggagggcc
     5581 catgtagtga cgcagacttc cgtctactta tgagtaactt tcgcggaagg gaaagctttg
     5641 tcatataaag tattctgtca agcgctttaa gaatgataag cctgtacaaa cttatgacaa
     5701 tgtgttctaa gcatgggaac cagttcatga gtttgttaaa tgtagttctg tcaacatggg
     5761 acatatgacg atgacatgtg tattgtatgt gaactttcta gacaaagtta tgttttaaac
     5821 aagataaaac tggtatatgc ttaccaggtt aagatttggt tttgtcctca ggtatagttt
     5881 atggtactac tgaaatagtt ttaatgttat tactctgatc tgaatttgta atatatagtc
     5941 tactttggga tgattaataa aaatttttaa tctcttgtg
//
LOCUS       NM_001436985            4050 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 4 (Dcun1d4), transcript variant 4, mRNA.
ACCESSION   NM_001436985 XM_006250907
VERSION     NM_001436985.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4050)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006250907.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.43230.1,
                                           SRR26643290.44242.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000014.1  35077179-35077311   c
            134-248             JAXUCZ010000014.1  35049628-35049742   c
            249-340             JAXUCZ010000014.1  35047027-35047118   c
            341-411             JAXUCZ010000014.1  35037634-35037704   c
            412-503             JAXUCZ010000014.1  35034530-35034621   c
            504-612             JAXUCZ010000014.1  35024657-35024765   c
            613-717             JAXUCZ010000014.1  35012393-35012497   c
            718-820             JAXUCZ010000014.1  35010391-35010493   c
            821-4050            JAXUCZ010000014.1  35006799-35010028   c
FEATURES             Location/Qualifiers
     source          1..4050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4050
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="defective in cullin neddylation 1 domain containing
                     4"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
     exon            1..133
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..876
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="isoform 4 is encoded by transcript variant 4;
                     DCN1-like protein 4; DCN1, defective in cullin neddylation
                     1, domain containing 4"
                     /codon_start=1
                     /product="DCN1-like protein 4 isoform 4"
                     /protein_id="NP_001423914.1"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
                     /translation="MHSDAAAVRSLRSCSSSDCFSKVMPPRKKRRPASGDDLSAKKSR
                     HDSMYRKYESTRIKTEEEAFSSKRCLEWFYEYAGTEDAVGPEGMEKFCEDIGVEPENV
                     VMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRTTLDYLRSLLNDTTNFKLIY
                     RYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLEQSKYKVINKDQWCNV
                     LEFSRTISLDLSNYDEDGAWPVLLDEFVEWYKDKQMS"
     misc_feature    520..852
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    520..852
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     exon            134..248
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            249..340
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            341..411
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            412..503
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            504..612
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            613..717
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            718..820
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            821..4050
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaggagccg ccggtcctct gttgagagct aaggtttggg gagtcggtag ggggaccgcg
       61 agtggagcgc gggagcccgg gcggcaggcg ggtgtgagct gcccgaaaat gcactcggat
      121 gctgcagctg tcagaagcct gcggtcttgc agttcttcgg actgctttag caaagtgatg
      181 ccgcccagga aaaagagaag acctgcctct ggagacgact tatctgccaa aaaaagcagg
      241 catgacagca tgtataggaa atacgagtca actagaataa agactgaaga agaggccttc
      301 tccagtaagc ggtgcctgga gtggttttat gaatatgcag gaactgagga tgcggtgggt
      361 cctgaaggca tggagaagtt ctgtgaagac attggtgttg agccagagaa cgtggttatg
      421 cttgtcctag cttggaaatt ggatgcacaa aacatgggct attttactct gcaggaatgg
      481 ctgaaaggaa tgacttccct acaatgtgat acaacagaaa aactcagaac tactttggat
      541 tacttaagat cattattaaa cgatacaaca aactttaagc tcatttacag atacgcgttt
      601 gactttgcac gggaaaagga ccagcgcagc ctagacataa acactgccaa gtgcatgttg
      661 ggactgttat taggaaaaat ctggcccctt tttccagttt ttcaccaatt cttagagcaa
      721 tcgaaatata aagtgataaa caaagaccag tggtgcaatg tgctggagtt cagcaggaca
      781 ataagtctcg acctcagcaa ctacgatgaa gacggagcat ggccagtttt gttggacgaa
      841 tttgtggaat ggtataaaga caagcagatg tcctaggacc ttatgcatag cagcgcgaga
      901 gtcactgtta ccacggtcat gtcacccatt agccataaac tgctgtttgt atcgaagcgc
      961 atgctgcttt tcttgcactg tctgcctctc gcaggggtgt ttggtgtttg ctattggatg
     1021 ggccgctctg cttgatgtgt agcattgttc tcttggaggc tgctctgcag tccattttca
     1081 cactacagat tggtgaattg ccaacgtcct cactgtgatt atgtgtatat tgctgtttaa
     1141 atttgtatat gtgtataaaa tgaaaagctt cacctagaga ttatttctgc aaaaatgtat
     1201 tgtaaaaata attttgtggc atatttttag tccccccctt tttttttcaa atgaaccagt
     1261 tatactttat ttggtctcaa atgtagcatt tcagaaaaca ttacaactgt ccccataagc
     1321 aagtattgcc agaatcaacc tcactgctta agaggccaac ttctggaaga agtaggagcc
     1381 gtgactttct gtggcataag ctaaatatga cttggttccc ttggcaactt tgatatttta
     1441 aagtgacaaa agttataatt tatttgagcg cacagacata tgacatgcta caaagcattt
     1501 ctaacacaaa aagtacaggt ttatgggggt ttttccttcc tcctcctctt cctcctcctt
     1561 aagttgctcc tcatttaaat tgaaaattaa gtttccatca atctttcact gtttcccgct
     1621 ttgtgttcct ctagcagtgt ttggtcagct gaagctctct gtgccactgt gagtaaaatg
     1681 tcccatgagc ctcctggttt gctggcggca taagcacttt gaactatggc ttgagacttt
     1741 agttcttctt gtatggcgtc tgtagcccac gagggttttg gagttttttg gtttgtttgt
     1801 tgttgttgtt gttgttgttg ttttaaacca caagtgagaa gtgtttgttt tctgtctgtt
     1861 tcttctgtgc tgggcttttc ctggcaacac gtccattgca ggcagtggac ttgaaaccac
     1921 cagcattgag ctaaccctgt tcatattggg acctttctca gaggggccac ttgtcattcc
     1981 cggagtcaca tgtacagagg gtggtagcca ttatgtggat gagaaaccag agccaacaca
     2041 gtggtagttg tgcatttgta ccttacgtct tatttttagg gtttgtactt gctcgccttg
     2101 cccctcttgc agaagcttac agttacaagt ttttccaact atttggtgct atgactcact
     2161 cagtccctga agtttgtgaa cacgtctgag atttaaccca gtaaagagcc atggcttgtt
     2221 tgctgggtaa acggtgtagt gggataagat ccgtgcctgc ccaggctgct gatgactgga
     2281 ggatattggg attatctgcc aaaaagaaaa aaaaatgtcc tctacattaa atgtgaacct
     2341 ttaaatggca ttaaatgatc agagcacaca gacaatgcta ccccgaccac cgtcctatag
     2401 ttccttttca gagtgttgct attttcatat ttctttccct gattgaacca ccaaagacag
     2461 aaatgtttat gtatgtaccg tgtgcgtgca tatgcaaaat catggtgtga tagaatgttt
     2521 atgtatatac cgtgtgcgtg catatgcaga atcatggtgt ggtagaaggc aaatacttgc
     2581 cttttcccac caaataatgc gatttggttt gctgtgaaaa ataaatcaga agtttgaaaa
     2641 accaacaaaa caagccaacg tttcttcagc atagttaatc atcctttgtc cgcagtctca
     2701 cagatttgta tctgaacaca atgtagactt cttggaaaac cacagctgtt gagactgctc
     2761 tgtgaaaggc attccagtgc atatgggtgt gtgacagtgg ggactgctaa agacaggcac
     2821 ggctctgtgg agaagggttc cttgtcgggt gtcccaaggt tacagaatca ttctctcagg
     2881 gcgctgttct ggaggtagat caactgttga tcgcctcatt gcaaggatgg accgtagatg
     2941 ggattgtttt aaacgctgtg tgggaatgga gagaatgttt taaacactaa gcacagtgga
     3001 tctgtgaata aagggttgtt accagggtga gaaattccat ttcatctaca gtgagcattt
     3061 tggtaatagt gactcaagta agaaccacca tgatgtatac ggtatggaag ttcgaattct
     3121 ggaggggata accaatattt agaactccag ataatgtctg gactgcctga agaaacaaac
     3181 cactgtgacg tggcttgcct ttggatttct cgattttaca gagctatttt taagggagtc
     3241 agacacagta ataagacacc ttttcttgaa gaatcgccaa gttacgcaag ttgaacgatc
     3301 accaagagca cttatggcca gcgtaggaag aagccagggc gccttcggtt ctccagtacc
     3361 tgagctccag ccacccttcc tcccttcacc tgtgtttcag ggcgctgcga ctcgtcttgt
     3421 tggggtacgc gacttgtaga catttccact gcactaggta gaagttacgt ggcaagattt
     3481 gctggatacc cattgtagcc ttaggtgcgc ctcttttgaa gcctgaactc ttgagttcag
     3541 tattgatatc tgattagaca aacctctaga ttctggttta acagatttct gttgcctcta
     3601 agtctccatc ctaaccatac ttttgaagtt tatacagaaa gctttaagag tttagtttgt
     3661 gtccttggtt tttattttta caactgctaa aatacctctg taagccttat cctttattct
     3721 ttcatagttg tataaaattg tatagaattc attgaccaac tgaaatgttg ggtatctgta
     3781 aatgagacca aaatgtggtt gcttttttcc ataaactgat ttccattggg cgctgctgtg
     3841 atgtgagcag cagccagcct gtgactgtga atgcctcgtg tcgtcagtat ttgcattaca
     3901 ttcatacaag tgtgcaagtc ctgtgactcc cagcttaact aaaatactgt catgccattt
     3961 aatgagcaca gaaaactggt ttaggtttta atggagttga tgtaaaatga tagcccataa
     4021 ataaacagat atttgtgttt ggtttccgaa
//
LOCUS       NM_001436988            3055 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus Meis homeobox 1 (Meis1), transcript variant 2,
            mRNA.
ACCESSION   NM_001436988 XM_063273628
VERSION     NM_001436988.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Yao,M.Z., Ge,X.Y., Liu,T., Huang,N., Liu,H., Chen,Y., Zhang,Z. and
            Hu,C.P.
  TITLE     MEIS1 regulated proliferation and migration of pulmonary artery
            smooth muscle cells in hypoxia-induced pulmonary hypertension
  JOURNAL   Life Sci 255, 117822 (2020)
   PUBMED   32450174
  REMARK    GeneRIF: MEIS1 regulated the proliferation and migration of
            pulmonary artery smooth muscle cells during hypoxia-induced
            pulmonary hypertension
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Zhang,Y., Si,Y. and Ma,N.
  TITLE     Meis1 promotes poly (rC)-binding protein 2 expression and inhibits
            angiotensin II-induced cardiomyocyte hypertrophy
  JOURNAL   IUBMB Life 68 (1), 13-22 (2016)
   PUBMED   26597775
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Pandey,R., Yang,Y., Jackson,L. and Ahmed,R.P.
  TITLE     MicroRNAs regulating meis1 expression and inducing cardiomyocyte
            proliferation
  JOURNAL   Cardiovasc Regen Med 3 (2016)
   PUBMED   28111633
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Jolma,A., Yin,Y., Nitta,K.R., Dave,K., Popov,A., Taipale,M.,
            Enge,M., Kivioja,T., Morgunova,E. and Taipale,J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Spieler,D., Kaffe,M., Knauf,F., Bessa,J., Tena,J.J., Giesert,F.,
            Schormair,B., Tilch,E., Lee,H., Horsch,M., Czamara,D., Karbalai,N.,
            von Toerne,C., Waldenberger,M., Gieger,C., Lichtner,P.,
            Claussnitzer,M., Naumann,R., Muller-Myhsok,B., Torres,M.,
            Garrett,L., Rozman,J., Klingenspor,M., Gailus-Durner,V., Fuchs,H.,
            Hrabe de Angelis,M., Beckers,J., Holter,S.M., Meitinger,T.,
            Hauck,S.M., Laumen,H., Wurst,W., Casares,F., Gomez-Skarmeta,J.L.
            and Winkelmann,J.
  TITLE     Restless legs syndrome-associated intronic common variant in Meis1
            alters enhancer function in the developing telencephalon
  JOURNAL   Genome Res 24 (4), 592-603 (2014)
   PUBMED   24642863
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063273628.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.62063.1,
                                           SRR21887623.80887.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               JAXUCZ010000014.1  97495016-97495753   c
            739-965             JAXUCZ010000014.1  97492951-97493177   c
            966-1107            JAXUCZ010000014.1  97491002-97491143   c
            1108-1158           JAXUCZ010000014.1  97490403-97490453   c
            1159-1209           JAXUCZ010000014.1  97489567-97489617   c
            1210-1356           JAXUCZ010000014.1  97487995-97488141   c
            1357-1468           JAXUCZ010000014.1  97465280-97465391   c
            1469-1614           JAXUCZ010000014.1  97417611-97417756   c
            1615-1691           JAXUCZ010000014.1  97381432-97381508   c
            1692-1754           JAXUCZ010000014.1  97361888-97361950   c
            1755-1840           JAXUCZ010000014.1  97360731-97360816   c
            1841-3055           JAXUCZ010000014.1  97356949-97358163   c
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..3055
                     /gene="Meis1"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
     exon            1..738
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    388..390
                     /gene="Meis1"
                     /note="upstream in-frame stop codon"
     CDS             727..2124
                     /gene="Meis1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     homeobox protein Meis1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog"
                     /codon_start=1
                     /product="homeobox protein Meis1 isoform 2"
                     /protein_id="NP_001423917.1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRAANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAGNQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMG
                     QPSYTQAQMPPHPAQLRHGPPMHTYIPGHPHHPAVMMHGGQPHPGMPMSASSPSVLNT
                     GDPTMSGQVMNIHAQ"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    <1702..2073
                     /gene="Meis1"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    <1702..2073
                     /gene="Meis1"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     exon            739..965
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1107
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1158
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1209
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1356
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1468
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1614
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1691
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1754
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1840
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..3055
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctggtcg gaatccacct ctccgcctgt gcaacacaca ctttacacac gcacggcgac
       61 tgcaagcggg cagcatcgat cgtggctcct ttaagacaaa ctcagacaga cattttttta
      121 accctcctct ctaatctccc ttcagtgcag cagttgcaaa gagggagaga gaaagagaaa
      181 gagagcgaga gaagagagaa actgattggg aattaggact gattcaagga aagcgggcgc
      241 tagggctttg tgcatttgaa tattaacatt tgaggtgttc tgaccagaag aagacagaac
      301 ggatgatcat tcattcacca cgttgacaac ctcgcctgtg attgacagct ggagtggcag
      361 aaagccatga gatttggtag ttggttctga ggggcgctct tttttttctt tttcttttct
      421 tttctttctt tttttttaac tgattttttt gggggggaag agaagatctg cttttttttc
      481 cctcccactg ctgtcttggt ggaaccagag cgcttttatg ctcagcgacg cgggcgcctt
      541 gcttcaggtc cggtagaccg aagatctggg accagtaatt cacactgctg gagacgcaaa
      601 gggatttttt tgttactgtt gtgctttatt tttttttccg agggagtttg catatttgtt
      661 tcttttcaca ctggccttaa agaggatata ttagaagttg aagaaggaag ggaggcagag
      721 aggccgatgg cgcaaaggta cgacgatcta ccccattatg ggggcatgga tggagtaggc
      781 atcccctcca cgatgtatgg ggacccgcat gcagccaggt ctatgcagcc ggtccaccac
      841 ctgaaccacg ggcctcctct gcactctcat cagtacccgc acacagctca taccaacgcc
      901 atggccccca gcatgggctc ctcagtcaat gacgctttaa agagagataa agatgccatt
      961 tatggacacc ccctcttccc tctcttagca ctgatttttg agaaatgtga attagctact
     1021 tgtacccccc gcgagccggg ggtggcgggc ggggacgtct gctcgtcaga gtcattcaat
     1081 gaagatatag cggtgttcgc caaacagatt cgtgcagaaa aacctctatt ctcttctaat
     1141 ccagaactgg ataacttgat gatccaagcc atacaagtat taaggtttca tctgttggaa
     1201 ttagagaagg tacacgaatt atgtgacaat ttctgccacc ggtatattag ctgtttgaaa
     1261 gggaaaatgc ctatcgattt ggtgatagat gatagagaag gcggatcaaa atcagacagt
     1321 gaagatgtaa caagagcagc aaatctaact gaccagccct cttggaatag agaccatgat
     1381 gacacggcat ccactcgttc aggaggaacc ccgggccctt ccagcggtgg ccacacttca
     1441 cacagtgggg ataacagcag tgagcaaggt gatggcttgg acaacagtgt agcttccccc
     1501 agcacaggtg acgatgatga ccctgataag gacaaaaagc gtcacaaaaa gcgtggcatc
     1561 tttcccaaag tagccaccaa tatcatgagg gcgtggctgt tccagcatct aacacaccct
     1621 tacccttctg aagagcagaa aaagcagttg gcacaagata cgggactcac catccttcaa
     1681 gtgaacaatt ggtttattaa tgcgcggaga agaatagtgc agcccatgat agatcagtcc
     1741 aaccgagcag gcaaccaagg gacaccttat aaccccgatg gacagccaat gggaggtttt
     1801 gtaatggacg gtcagcagca catgggcatc agagcgccag ggctgcaaag tatgccaggg
     1861 gagtatgtag cccggggtgg tccaatgggt gtgagtatgg gacagccgag ttatacccaa
     1921 gcccagatgc ccccccatcc tgctcagctg cgtcatgggc cccccatgca tacgtacatt
     1981 cctggacatc ctcaccaccc cgcagtgatg atgcatggag gacagcccca ccctggaatg
     2041 ccaatgtcag cgtcaagccc ctcggttctt aatacaggag acccgacaat gagtggacaa
     2101 gtcatgaaca ttcacgctca gtagcttaag ggaatatgca ttgtctgcaa tggtgactga
     2161 tctcgaatca tgtctttttc tgcaatgact atggagttcc attcttgaca tctactttgg
     2221 accaaggagc atccctaatt cttcataggg actcttaaaa atgcaggaaa accaaccgaa
     2281 gtcaatttgg gggacatgca aaaataacta tataagacat taaaagaaca aagagtgaaa
     2341 tattgtaaat gctattatac tgttatccat attacgttgt ttcttataga ttttttaaaa
     2401 aaaatgtgaa atttttccac actatgtgtg ttgtttccat agctcttcac ttcctccaga
     2461 agcctcctta cattaaaaag ccttacagtc atcctgcaag ggacaggaag gtctgatttg
     2521 caggattttt agagcattaa aataactatc aggcagaaga atctttcttc tcgcctagga
     2581 tttcagccat gtgcgcgctc tctctctctc tcctctctct ctcttctcct ctctctccct
     2641 ctctctagcc tggggcttga atttgcatgt ctaattcatt tactcaccat atttgaattg
     2701 gcctgaacag atgtaaatcg ggaaggatgg gaaaaactgc agtcacccaa caatgattaa
     2761 tcagctgttg caggcagtgt cttaaggaga ctggtagaag gagccatgga aacccaaagg
     2821 ccgtgtgttt agaagcctaa ctgtcacgtc aagcgtcatc gtccccatgc gacaacaacc
     2881 atcaccttat acatcacttc ctgttttatg cagctcaaaa aaacatagac tgaagattta
     2941 tttttaatat gttgactttg tttctcagca aagcattggt catgtgtgta tttttccata
     3001 gtcccacctt ggagcattta tgtagacatt gtaaataaat tttgtgcaaa aagga
//
LOCUS       NM_001436984            4056 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 4 (Dcun1d4), transcript variant 3, mRNA.
ACCESSION   NM_001436984 XM_063273337
VERSION     NM_001436984.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4056)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063273337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.54138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000014.1  35077179-35077311   c
            134-204             JAXUCZ010000014.1  35057754-35057824   c
            205-244             JAXUCZ010000014.1  35057543-35057582   c
            245-359             JAXUCZ010000014.1  35049628-35049742   c
            360-451             JAXUCZ010000014.1  35047027-35047118   c
            452-522             JAXUCZ010000014.1  35037634-35037704   c
            523-614             JAXUCZ010000014.1  35034530-35034621   c
            615-723             JAXUCZ010000014.1  35024657-35024765   c
            724-826             JAXUCZ010000014.1  35010391-35010493   c
            827-4056            JAXUCZ010000014.1  35006799-35010028   c
FEATURES             Location/Qualifiers
     source          1..4056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4056
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="defective in cullin neddylation 1 domain containing
                     4"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
     exon            1..133
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..882
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="isoform 3 is encoded by transcript variant 3;
                     DCN1-like protein 4; DCN1, defective in cullin neddylation
                     1, domain containing 4"
                     /codon_start=1
                     /product="DCN1-like protein 4 isoform 3"
                     /protein_id="NP_001423913.1"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
                     /translation="MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDVGQDDHQ
                     TGSLRSCSSSDCFSKVMPPRKKRRPASGDDLSAKKSRHDSMYRKYESTRIKTEEEAFS
                     SKRCLEWFYEYAGTEDAVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQE
                     WLKGMTSLQCDTTEKLRTTLDYLRSLLNDTTNFKLIYRYAFDFARQSKYKVINKDQWC
                     NVLEFSRTISLDLSNYDEDGAWPVLLDEFVEWYKDKQMS"
     misc_feature    631..858
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    631..858
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     exon            134..204
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            205..244
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            245..359
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            360..451
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            452..522
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            523..614
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            615..723
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            724..826
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            827..4056
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaggagccg ccggtcctct gttgagagct aaggtttggg gagtcggtag ggggaccgcg
       61 agtggagcgc gggagcccgg gcggcaggcg ggtgtgagct gcccgaaaat gcactcggat
      121 gctgcagctg tcaactttca gctgaactct catctctcaa cactggcaaa cattcataag
      181 atctaccaca cccttaacaa gctaaatctg acagaagacg ttggccaaga cgatcaccaa
      241 acaggaagcc tgcggtcttg cagttcttcg gactgcttta gcaaagtgat gccgcccagg
      301 aaaaagagaa gacctgcctc tggagacgac ttatctgcca aaaaaagcag gcatgacagc
      361 atgtatagga aatacgagtc aactagaata aagactgaag aagaggcctt ctccagtaag
      421 cggtgcctgg agtggtttta tgaatatgca ggaactgagg atgcggtggg tcctgaaggc
      481 atggagaagt tctgtgaaga cattggtgtt gagccagaga acgtggttat gcttgtccta
      541 gcttggaaat tggatgcaca aaacatgggc tattttactc tgcaggaatg gctgaaagga
      601 atgacttccc tacaatgtga tacaacagaa aaactcagaa ctactttgga ttacttaaga
      661 tcattattaa acgatacaac aaactttaag ctcatttaca gatacgcgtt tgactttgca
      721 cggcaatcga aatataaagt gataaacaaa gaccagtggt gcaatgtgct ggagttcagc
      781 aggacaataa gtctcgacct cagcaactac gatgaagacg gagcatggcc agttttgttg
      841 gacgaatttg tggaatggta taaagacaag cagatgtcct aggaccttat gcatagcagc
      901 gcgagagtca ctgttaccac ggtcatgtca cccattagcc ataaactgct gtttgtatcg
      961 aagcgcatgc tgcttttctt gcactgtctg cctctcgcag gggtgtttgg tgtttgctat
     1021 tggatgggcc gctctgcttg atgtgtagca ttgttctctt ggaggctgct ctgcagtcca
     1081 ttttcacact acagattggt gaattgccaa cgtcctcact gtgattatgt gtatattgct
     1141 gtttaaattt gtatatgtgt ataaaatgaa aagcttcacc tagagattat ttctgcaaaa
     1201 atgtattgta aaaataattt tgtggcatat ttttagtccc cccctttttt tttcaaatga
     1261 accagttata ctttatttgg tctcaaatgt agcatttcag aaaacattac aactgtcccc
     1321 ataagcaagt attgccagaa tcaacctcac tgcttaagag gccaacttct ggaagaagta
     1381 ggagccgtga ctttctgtgg cataagctaa atatgacttg gttcccttgg caactttgat
     1441 attttaaagt gacaaaagtt ataatttatt tgagcgcaca gacatatgac atgctacaaa
     1501 gcatttctaa cacaaaaagt acaggtttat gggggttttt ccttcctcct cctcttcctc
     1561 ctccttaagt tgctcctcat ttaaattgaa aattaagttt ccatcaatct ttcactgttt
     1621 cccgctttgt gttcctctag cagtgtttgg tcagctgaag ctctctgtgc cactgtgagt
     1681 aaaatgtccc atgagcctcc tggtttgctg gcggcataag cactttgaac tatggcttga
     1741 gactttagtt cttcttgtat ggcgtctgta gcccacgagg gttttggagt tttttggttt
     1801 gtttgttgtt gttgttgttg ttgttgtttt aaaccacaag tgagaagtgt ttgttttctg
     1861 tctgtttctt ctgtgctggg cttttcctgg caacacgtcc attgcaggca gtggacttga
     1921 aaccaccagc attgagctaa ccctgttcat attgggacct ttctcagagg ggccacttgt
     1981 cattcccgga gtcacatgta cagagggtgg tagccattat gtggatgaga aaccagagcc
     2041 aacacagtgg tagttgtgca tttgtacctt acgtcttatt tttagggttt gtacttgctc
     2101 gccttgcccc tcttgcagaa gcttacagtt acaagttttt ccaactattt ggtgctatga
     2161 ctcactcagt ccctgaagtt tgtgaacacg tctgagattt aacccagtaa agagccatgg
     2221 cttgtttgct gggtaaacgg tgtagtggga taagatccgt gcctgcccag gctgctgatg
     2281 actggaggat attgggatta tctgccaaaa agaaaaaaaa atgtcctcta cattaaatgt
     2341 gaacctttaa atggcattaa atgatcagag cacacagaca atgctacccc gaccaccgtc
     2401 ctatagttcc ttttcagagt gttgctattt tcatatttct ttccctgatt gaaccaccaa
     2461 agacagaaat gtttatgtat gtaccgtgtg cgtgcatatg caaaatcatg gtgtgataga
     2521 atgtttatgt atataccgtg tgcgtgcata tgcagaatca tggtgtggta gaaggcaaat
     2581 acttgccttt tcccaccaaa taatgcgatt tggtttgctg tgaaaaataa atcagaagtt
     2641 tgaaaaacca acaaaacaag ccaacgtttc ttcagcatag ttaatcatcc tttgtccgca
     2701 gtctcacaga tttgtatctg aacacaatgt agacttcttg gaaaaccaca gctgttgaga
     2761 ctgctctgtg aaaggcattc cagtgcatat gggtgtgtga cagtggggac tgctaaagac
     2821 aggcacggct ctgtggagaa gggttccttg tcgggtgtcc caaggttaca gaatcattct
     2881 ctcagggcgc tgttctggag gtagatcaac tgttgatcgc ctcattgcaa ggatggaccg
     2941 tagatgggat tgttttaaac gctgtgtggg aatggagaga atgttttaaa cactaagcac
     3001 agtggatctg tgaataaagg gttgttacca gggtgagaaa ttccatttca tctacagtga
     3061 gcattttggt aatagtgact caagtaagaa ccaccatgat gtatacggta tggaagttcg
     3121 aattctggag gggataacca atatttagaa ctccagataa tgtctggact gcctgaagaa
     3181 acaaaccact gtgacgtggc ttgcctttgg atttctcgat tttacagagc tatttttaag
     3241 ggagtcagac acagtaataa gacacctttt cttgaagaat cgccaagtta cgcaagttga
     3301 acgatcacca agagcactta tggccagcgt aggaagaagc cagggcgcct tcggttctcc
     3361 agtacctgag ctccagccac ccttcctccc ttcacctgtg tttcagggcg ctgcgactcg
     3421 tcttgttggg gtacgcgact tgtagacatt tccactgcac taggtagaag ttacgtggca
     3481 agatttgctg gatacccatt gtagccttag gtgcgcctct tttgaagcct gaactcttga
     3541 gttcagtatt gatatctgat tagacaaacc tctagattct ggtttaacag atttctgttg
     3601 cctctaagtc tccatcctaa ccatactttt gaagtttata cagaaagctt taagagttta
     3661 gtttgtgtcc ttggttttta tttttacaac tgctaaaata cctctgtaag ccttatcctt
     3721 tattctttca tagttgtata aaattgtata gaattcattg accaactgaa atgttgggta
     3781 tctgtaaatg agaccaaaat gtggttgctt ttttccataa actgatttcc attgggcgct
     3841 gctgtgatgt gagcagcagc cagcctgtga ctgtgaatgc ctcgtgtcgt cagtatttgc
     3901 attacattca tacaagtgtg caagtcctgt gactcccagc ttaactaaaa tactgtcatg
     3961 ccatttaatg agcacagaaa actggtttag gttttaatgg agttgatgta aaatgatagc
     4021 ccataaataa acagatattt gtgtttggtt tccgaa
//
LOCUS       NM_001437011            6530 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 8, mRNA.
ACCESSION   NM_001437011
VERSION     NM_001437011.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6530)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6530)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6530)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 6530)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 6530)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 6530)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 6530)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 6530)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 6530)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 6530)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2410013.1,
                                           SRR22582419.714723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN17050752
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000005.1  73135386-73135944
            560-769             JAXUCZ010000005.1  73140265-73140474
            770-972             JAXUCZ010000005.1  73142997-73143199
            973-1032            JAXUCZ010000005.1  73151592-73151651
            1033-1236           JAXUCZ010000005.1  73152711-73152914
            1237-1514           JAXUCZ010000005.1  73158194-73158471
            1515-1647           JAXUCZ010000005.1  73160426-73160558
            1648-1777           JAXUCZ010000005.1  73165478-73165607
            1778-1911           JAXUCZ010000005.1  73169494-73169627
            1912-2039           JAXUCZ010000005.1  73170920-73171047
            2040-6530           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..6530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6530
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..559
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            560..769
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    751..753
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            770..972
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             868..2253
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 8;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423940.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    868..1701
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    868..1701
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1732..>1848
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1732..>1848
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            973..1032
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1236
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1514
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1647
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1777
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1911
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2039
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..6530
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg caggtacgcg agcttgctgc
      181 cgccacaggg acagatgggt ctcacatgcc catgctgttc gttgatcatc ctgacaccgc
      241 ttcgattttt ggaggttcat ggagacgctt gtagaggccg ggttggaaca gtgatgtttg
      301 agctgggcgg cgagagcgaa ccacgcgagt agaacgatcg gtcgggtgtg aggaccaatt
      361 ccttgccaag gttcctccgc aggggaggaa ctgctgcagc ccgctgctct gagtgcatcc
      421 tccgcggtgg ctggaggcat gaactcactg ggaaaggaag ggagaatggc cacccaggga
      481 gggttccacg aggcgaattt tggtcctgcg cgaaagacaa gttctgtgta gagcagccat
      541 ctgccaccct tcgaagggaa ttcagattgt gtgtgtggat tgtttcaaag ctccgcacaa
      601 agacttagga ctttaattaa aatggcagag tgaaaatact tgtactttat tcaatctgaa
      661 gttaccctga aaaaaacatg aaaaatggaa gatggatctt aacacagctt ccccaacgca
      721 aatattgctg tgaccccaaa ctgaaatgtt tgagaggtgg ttgccacaga agtacctctg
      781 ttgacaggaa acaagattct gtttcataaa gaagatgaaa acaactgggt tcctgttaac
      841 aaacacccaa gagaccagca tagaccaatg agcagagtca ataagaacgt ggtcttggcc
      901 cttctaacac tgatgagctg tgccttcctg ctgtttcagc tgtactacta caagcactac
      961 ttgtcagcac ggaatggaac gggttcatca aaatccaaag gaaatcgagt tggatttgat
     1021 agcacacaat ggcgtgcagt taagaaattt attatgctga catccagcca aaatgtgccg
     1081 gtgttcctta ttgacccttg gattctggaa tcaattaata aaaatttcga acaagtgaaa
     1141 aatgcctctc aaggctcggc ctcagaatgc agatttttct gtgttccgag agacttcact
     1201 gcgttcgcgc tgcagtatca cctgtggaag aatgaggatg gatggtttca gatggctgag
     1261 aacatgggat tccagtgcct gaagattgaa agcaaagatc ctcggctgga tggaatagac
     1321 tcgctttccg gaactgagat ccctctgcac tatgtctgta agctggccac tcacgccatc
     1381 cacttggtcg tctttcacga gaggagtggc aactacctct ggcatggtca cctacgactc
     1441 aaagggcaca tggataggaa gtttgttcct tttcgaaggc tacaatttgg tcgttatcct
     1501 ggagcctttg acaggccgga gttacagcag gttactgttg atggactcga catgcttatt
     1561 ccaaaagacc cagggcgctt tctagaagaa gtacctcact ccagatttat cgagtgcagg
     1621 tataaagaag cccgggcatt ccttcagcag tacgtcgatg acaacactgt ggatgccatg
     1681 gcctttcgga agagggcaaa ggagttactg caactagcgg ccaagacgct gaaggcgctg
     1741 ggagtgccct tctggctgag cagtgggacg tgtctaggat ggtatcggca atgcagtatc
     1801 attccttata gcaaagatgt cgacctagga attttcattc aagattacaa acctgatatt
     1861 gttttggcat ttcaggatgc aggacttcca ctcaaacaca agtttgggaa ggtggaggac
     1921 agcttggaac tctccttcca gggacaagct gatgtaaaac ttgatatttt tttcttctat
     1981 gaagagactg accatatgtg gaatggaggc acgcaggcca gaacaggaaa gaagtttaag
     2041 tatctgttcc ccaagtttac actgtgctgg acggagtttg tagacataaa agtccatgtt
     2101 ccctgtgaaa cagttgacta cattgaagcc aactatggca aggcctggaa gatccctgtc
     2161 aagacctggg actggaagag ctcacccccg aatgtgcagc ccaatggggt ctggcctatt
     2221 tcggagtggg atgaagttat ccagttgtac tgagaacact gagctcatgt gggacgtttc
     2281 ccagaaagaa ggtaggcagc tgttgaaagc actatgtttt ctgcctgatg tgagagccaa
     2341 agaggagaaa tgacgagttg gaagacagaa aaggttttct gactcatggg ccatctaatc
     2401 agttctgcca ctcagcattt actgaggagt ttatacacca ggtgaagtac taggatctgg
     2461 tgaacaggca gagaggaatg agaggccagc ttctctcttg ccctgttggt aagcactaca
     2521 attttatgtt aagggaaact aacccactct ctgaagaggt gtacagtaga atgtattcca
     2581 taatgatttt taaaatgtta attaatgttt aaaccggaaa gtgagctcat cagacaaagc
     2641 taacaaagga tgtgttagtt gagagtagtt catttctgcc tgccctcggg atttaagctg
     2701 ctgtgttagt gttaaggttg tgggatatga gttaatattc cagtgagtga ttagactttg
     2761 tctcacagag aaaagacagt ggccaactca ttttacaagc agtgtgatac acagttgact
     2821 tcaagcactg ggcattctat aagggaggat gagagccgat agcagctctt gtcaagacgt
     2881 acactgtttt catctttgag atgaacatgg atgcttagat ggtgcttgaa tccctgacat
     2941 cataaggata ttttcactga cctgcagtag tacttcctga taaatcattc agtcgtgcta
     3001 tccaaaagtt gtgacatctc aaagcttccg ttccttattt cattcttagt cactcttaaa
     3061 ctcaaaaatg gaagttactc atgaatattt ttatatttta tgaatgtata acttttctgc
     3121 ctttaatttt aatattgaca ctaagtaata atagacatac ctcttaattt tttaaaaata
     3181 ccctttattt atttatcaac catagttcca tgtgtttaat ttatggccta cacactaatt
     3241 tatttagcac aagatatgcc tgttcttcta tccaatatta cttcacggtt ccaaaatgaa
     3301 gggttaacgt gaacctggcc attactcctt ttcccagatt actgtcttta aagcctgtgt
     3361 ccatctctag attttcattc tgctgagtgt aatagggcaa gggcttccta cccacaagta
     3421 ctgcacaagt gggacccttg acctacactc ctgagtccat tgtagtggct gcacataagc
     3481 catgcagtct cagagagaga tgacacagtg agtgcctgcc tgccttgcct gggaggggag
     3541 ggtccactcc ctgctgctta gggatgtgct tcatggcaac ctggcagatt tcccttggca
     3601 cgtgtagtta ctacagcaga aaccaggata gatgagagaa tgggctggca gaaagaaaag
     3661 aaaaaagaaa gaaaaagaaa aacttggagg aagtaacttg aagccaccta tttccaaatt
     3721 taaacttcaa catgaaaact gtctttgttg gatgatatgc agcagtctcc atgcagcctc
     3781 caagtaggaa tattgtctct ccataagcat catctaatca gagtgttaca gttattagca
     3841 cacatgtacc caaatgacaa atcataatca gctctttcct agaaaataag tccatagaat
     3901 acgtacccaa gttgtagata cccaacccta catatttttc tgtgtgcgca tgcgtgtgca
     3961 cgcacacacc cccactcgca cacaccagat aatagtgttt ttgaggacaa acccacccta
     4021 cctggagagg atcatttact tgtactcaat atcaagaagt atgtttatat cgtgttcctt
     4081 gagagctccc accttctgcc aggagatctt acccacccct gtttaagttt cttctctcat
     4141 acctgtcgtt ggagtgcaag gtctgccagt gtccataata caagctcttg gtcctgggca
     4201 cagaggttct gtagtcttcc cttcatagag gatgggtacc tgttttccct ctggtttggc
     4261 tttaggtttt aggttccgcc caccgtggag aaattttccc agaatttgca ggtgaggttt
     4321 acctctaaaa atgactccat gattcagtca tactgaagtc agtgcttctt aactcttgaa
     4381 ctctgctgag tgtcccgaga tcttgggtca ggtctgccca ccacctgaac cttttcagat
     4441 cacttctctt ccctccctga atatgctaac tgttattctc ctaatatgag tgctttctgg
     4501 tcccatttgc ctggactgct tgaagatacc tttacattaa ctcattggta gttctgctgc
     4561 cgaggatctt tcagagggac cctgagaagc agatgctttc tcggtttacg acagccatct
     4621 acttccctaa gcgtggagga cttgccccgc tcttggttac agttactgac attggccact
     4681 gagatgaaat aatagtaact aaaactggcc tccctgagag tacctgagat ccgttcttag
     4741 tgtggcctcc atgacactcc agtgcttggt gagtcctcca gtgcctcagt gcctgccatt
     4801 ccccacggaa ggcctgaggc gacagaaaat gctgaggagg gatgtttcct cttgtccaga
     4861 attctcaggc taccgtctca cctttgtctg gggagggttc aggaggtggg ccaagggagg
     4921 ggaagcctta tctacaaaaa atagaacagt ttatgtctga agacatcacc agaagtcagt
     4981 ttctgactct tgaaatgttt aaaggattta atgatgcata cagtgcttcc attcaggccc
     5041 agcgttaagt aagtactcgc catttcctag ttctcggttc ctttgtaacg tggaaggctg
     5101 cacgacagag ttgcttagaa ctaaaattgg ggcactgctg agatggctta gcaggcaaaa
     5161 gcccttgtca ccaaaagtga catgagtttg attcccagga cccatgtaat ggaaggaaag
     5221 aatctcaaat tgcttgtcat ccaatacaca gactctgatg tgcttggagc tcctctctag
     5281 catgagagga caccacacac acacacacac acacacacac acacacacac acacacacac
     5341 acacacacac acactaagta aatataatgg aaagttttta ttttatctaa gcattacagg
     5401 tcgaattatg tgatttttga gtcattgcca tattccctcc acctgaaaca gagctggttc
     5461 tcacttagtt gaccaagtgg ttgtcttcta atcctatcct attgtactat accctttaag
     5521 cacagtcaga ttgctcttaa gttttgtgcc ttgattttca atagtccagc tttgggcagc
     5581 taacatcact atatataatg atttggagaa ccaaagattt tggaatgctt agttttattt
     5641 acctgcctag tctgtataga aatgtgggct agttagtcta attgcccagc atgtgtgagg
     5701 tctggattca gtacaaagca ccagaagtct gagacagaag acttagcaca tgctgaaggc
     5761 cagcttgggc tacctagtga gtaccagcct atcctgggct acagtgtaag accctatatt
     5821 gattgaggac acaggaggga agagagaaac agagacagaa tgagaatata ctcctgtcag
     5881 ccatctgccc atagatgtat gttttaatct aagcgaggca aaatcaggat atatagtgtg
     5941 gatttttaaa tagttaattg tagacaatta acagccaatt cgatattgat gctttttgta
     6001 taggaccaat aggcaagtgt aatgtgttga gaaacgtatt tccaaacact cagaacacct
     6061 aggctaaagc ctgctcctgt aactcctgga cctaacgtag aaggatcgaa gaatctctgt
     6121 gagggagggc ccatgtagtg acgcagactt ccgtctactt atgagtaact ttcgcggaag
     6181 ggaaagcttt gtcatataaa gtattctgtc aagcgcttta agaatgataa gcctgtacaa
     6241 acttatgaca atgtgttcta agcatgggaa ccagttcatg agtttgttaa atgtagttct
     6301 gtcaacatgg gacatatgac gatgacatgt gtattgtatg tgaactttct agacaaagtt
     6361 atgttttaaa caagataaaa ctggtatatg cttaccaggt taagatttgg ttttgtcctc
     6421 aggtatagtt tatggtacta ctgaaatagt tttaatgtta ttactctgat ctgaatttgt
     6481 aatatatagt ctactttggg atgattaata aaaattttta atctcttgtg
//
LOCUS       NM_001436965            2733 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 4, mRNA.
ACCESSION   NM_001436965 XM_063287912
VERSION     NM_001436965.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287912.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.19197.1,
                                           SRR26643429.19404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000005.1  65211340-65211573   c
            235-439             JAXUCZ010000005.1  65207932-65208136   c
            440-753             JAXUCZ010000005.1  65204444-65204757   c
            754-874             JAXUCZ010000005.1  65202357-65202477   c
            875-1000            JAXUCZ010000005.1  65198348-65198473   c
            1001-1106           JAXUCZ010000005.1  65197553-65197658   c
            1107-1225           JAXUCZ010000005.1  65194234-65194352   c
            1226-1384           JAXUCZ010000005.1  65193640-65193798   c
            1385-1523           JAXUCZ010000005.1  65192934-65193072   c
            1524-1652           JAXUCZ010000005.1  65182204-65182332   c
            1653-1720           JAXUCZ010000005.1  65181732-65181799   c
            1721-2733           JAXUCZ010000005.1  65175330-65176342   c
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2733
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..234
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            235..439
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             275..1702
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform b is encoded by transcript variant 4;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform b"
                     /protein_id="NP_001423894.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSGSGKSGLWREQWTKSSSGYDKSRSLCPQHPQHIL
                     KLKNLPGSVYLSDPLPSFHTMSCSP"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     misc_feature    779..>1489
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="tRNA U34 5'-hydroxylase TrhO, rhodanese family
                     [Translation, ribosomal structure and biogenesis]; Region:
                     TrhO; COG1054"
                     /db_xref="CDD:440674"
     exon            440..753
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1000
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1106
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1225
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1523
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1652
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1720
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..2733
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcacgacg cctgccggaa gcgcgagcgg agaggcaccg gatgggtttc gcggtggaag
       61 gccggcgtct gcaagtccaa gctcagccgc ctcctccggc tttccactct gggaccttcc
      121 ggacggcgag ctaaattatc cgggctgcaa cgatcccgcc tcagctttgc acaggcccag
      181 cagtattttc ccggcggccc ctgcgccgac gactttggag acttccggag atagatactt
      241 gactgaaagg gatccatccc actgataaaa ccagatgcct tctcccactt cagcagacga
      301 agaggatggc ctggagacct gtgttttaaa gacttttgat ctggatttaa aagaatcaaa
      361 tattgttact ccaagcaata gtctcaaagc agagttagat ggcagtacaa agaagaaata
      421 ctcgtttgca aagaaaaagg cctttgccct ttttgtcaaa accaaacaag ttccagtgcc
      481 ttcttatgaa gttaaggaaa gacggtggcg atgttgtcag cagctgtttg cagagcagac
      541 cagcatccac agacatgtgg ccacacagca cgctgaagac gtgtaccagc agactgcttc
      601 cattctcaag cagctcactg cagcactgag gaccccacag agtcttacgc ccacagaccg
      661 gaggagctcc ccaaaagact gtctccctcc tagtcaggat gtgtctgctt ggctccctga
      721 tgtgagccac gttagcccgc aagagctgag gagtggccag ggcaatgagg aaggagaggt
      781 gctcctgtat tactgctact gtgacttgga ggaccccgac tgggtctgtg cctggcaggc
      841 agctctgtgc cgtcacctgc accttacagg caagattcgg atcgcgacag aaggaatcaa
      901 tggaaccgtt ggaggaagca aagtggccac ccgactctac atggaagtca tgctttcttg
      961 cccattattt aaggattacc tgagcgagga tgattttaag agcagcaaag gagggtctca
     1021 ctgcttcccg gaattgcgag tcggtgtgtt cgaagagatc gtgcccatgg ggatcagccc
     1081 cagtgaggtc tcctacaaga accccggaat ccatttatcc cctggagaat ttcataaaga
     1141 aatagaaaaa ctattgtcac aggcaaatca ggaacaaggt gatactctcc tactggactg
     1201 caggaacttc tatgaaagca aaataggacg attccagggc tgcttagcac cagacatcag
     1261 gaagttcagt tacttcccta gctacgttga caaaaacctt gacattttca ggcagaagag
     1321 ggtgctgatg tactgcactg ggggcattcg ctgcgaacgg ggttctgcat acctcagagc
     1381 caagggagtg tgtaaggaag tgtttcagct caagggtggc atccacaagt atctagaaga
     1441 gtttcctgat ggatttttca aagggaagct gtttgttttt gatgagcggt ttgccctggc
     1501 ctacaacagt gctgtggtct caggctctgg aaaaagtggc ctgtggcgtg agcagtggac
     1561 aaagagctct tcaggttatg ataagagcag gagtctgtgt ccccagcatc ctcagcacat
     1621 cctgaagttg aagaacttgc ctggaagtgt gtatttgtca gacccactgc cttcgtttca
     1681 caccatgtcc tgttctcctt agtagcatca ggaacacgtg aaaattccca agctagtact
     1741 ggagaaccac caccttgttt tttttgtttg tttgtttgtt ttttgttttt ttttgttttt
     1801 gttttttttt gtttttgttt taaactgctt cttggggtgc ccctgagatg ctgcagtgca
     1861 gacagctgtc tgcatccaca cctcgtccca cacaaggcag tgcagtggac tctgccggag
     1921 aagagagatt attctacagt tgactagtgt tgggttgaga gagaagcaca cttcggtggt
     1981 agcagcttat gtcctcgcct gcttacagcg actgagggtt ttcagtttga tgagattgtg
     2041 acaaaagcct caggtgttga ggtctatgat gagggcctgg tggctgtgac cctggatgtc
     2101 agaccattcc ttcgctcatt tgacagtcca ctttatcgtg acctagagga catgtgcagc
     2161 tggagcaccg aaaatacatc ctcgtgccag gtgcggtgtc acacaccttt aatcccagca
     2221 cgagcagatc tctgtgagtt caaggccagc gtgctctaca tagtgaattc cagaacagcc
     2281 aaaactatat agtgagacta tatatactta gtctcaaaaa aaaaaaaaaa aaaaagaaga
     2341 agaaagaaaa gaaagaagag acatcagcca ggtatcctgg aagtacttgg ccaacaccag
     2401 ggccatatgc cacctctcac tggcataagc atcactctgt ttgcaagctg ccaattctgc
     2461 tctgccgaca caccactggg gaagaagctc accacctgag ggacacctgc tttgtcctgg
     2521 ggtagcgctg ctgattagaa aggccttcct caccaaagtg ctacaacgta gaagagtaca
     2581 ggggacgagt atggcagtga tttaaggtag tctgcatcga ggagtggaga gggataactg
     2641 acttgaagta tattttgaaa aaaagaaatc acatgagaat gcttgcccca gacgccatag
     2701 gttgctgaat aaaaatccca gtgccagata tga
//
LOCUS       NM_001436964            3390 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 3, mRNA.
ACCESSION   NM_001436964 XM_063287909
VERSION     NM_001436964.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287909.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18847.1,
                                           SRR26643296.15133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               JAXUCZ010000005.1  65211053-65211292   c
            241-445             JAXUCZ010000005.1  65207932-65208136   c
            446-759             JAXUCZ010000005.1  65204444-65204757   c
            760-880             JAXUCZ010000005.1  65202357-65202477   c
            881-1006            JAXUCZ010000005.1  65198348-65198473   c
            1007-1112           JAXUCZ010000005.1  65197553-65197658   c
            1113-1231           JAXUCZ010000005.1  65194234-65194352   c
            1232-1390           JAXUCZ010000005.1  65193640-65193798   c
            1391-1529           JAXUCZ010000005.1  65192934-65193072   c
            1530-3390           JAXUCZ010000005.1  65188829-65190689   c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3390
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..240
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            241..445
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    272..274
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             281..1762
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform a is encoded by transcript variant 3;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform a"
                     /protein_id="NP_001423893.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSECSYCGAPWDQYKLCSTPQCRQLVLTCSACQGQG
                     FTACCVMCQDKGGKQASDPTQDSFKEECECTARRPRIPQEQRA"
     misc_feature    785..1657
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    785..1657
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    1340..1342
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     misc_feature    1340..1342
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     exon            446..759
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            760..880
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1006
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1112
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1231
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1390
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1529
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..3390
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggctcca gggcggggag cagcgccaag ttggagaagg gagacccagg aaaggcctag
       61 gtattgcggg tacgtgttct cgcttttgcc gtctggctgt agacgtctcg ggaaaactga
      121 gcggggaaga agggcaagcc actctcagcg gtaggggagc caggcccgcc cggccgagcc
      181 tgcttactgc cgtcctactg ctcacctctt ccagctgacg ggcgcctcag ctattgatcg
      241 atacttgact gaaagggatc catcccactg ataaaaccag atgccttctc ccacttcagc
      301 agacgaagag gatggcctgg agacctgtgt tttaaagact tttgatctgg atttaaaaga
      361 atcaaatatt gttactccaa gcaatagtct caaagcagag ttagatggca gtacaaagaa
      421 gaaatactcg tttgcaaaga aaaaggcctt tgcccttttt gtcaaaacca aacaagttcc
      481 agtgccttct tatgaagtta aggaaagacg gtggcgatgt tgtcagcagc tgtttgcaga
      541 gcagaccagc atccacagac atgtggccac acagcacgct gaagacgtgt accagcagac
      601 tgcttccatt ctcaagcagc tcactgcagc actgaggacc ccacagagtc ttacgcccac
      661 agaccggagg agctccccaa aagactgtct ccctcctagt caggatgtgt ctgcttggct
      721 ccctgatgtg agccacgtta gcccgcaaga gctgaggagt ggccagggca atgaggaagg
      781 agaggtgctc ctgtattact gctactgtga cttggaggac cccgactggg tctgtgcctg
      841 gcaggcagct ctgtgccgtc acctgcacct tacaggcaag attcggatcg cgacagaagg
      901 aatcaatgga accgttggag gaagcaaagt ggccacccga ctctacatgg aagtcatgct
      961 ttcttgccca ttatttaagg attacctgag cgaggatgat tttaagagca gcaaaggagg
     1021 gtctcactgc ttcccggaat tgcgagtcgg tgtgttcgaa gagatcgtgc ccatggggat
     1081 cagccccagt gaggtctcct acaagaaccc cggaatccat ttatcccctg gagaatttca
     1141 taaagaaata gaaaaactat tgtcacaggc aaatcaggaa caaggtgata ctctcctact
     1201 ggactgcagg aacttctatg aaagcaaaat aggacgattc cagggctgct tagcaccaga
     1261 catcaggaag ttcagttact tccctagcta cgttgacaaa aaccttgaca ttttcaggca
     1321 gaagagggtg ctgatgtact gcactggggg cattcgctgc gaacggggtt ctgcatacct
     1381 cagagccaag ggagtgtgta aggaagtgtt tcagctcaag ggtggcatcc acaagtatct
     1441 agaagagttt cctgatggat ttttcaaagg gaagctgttt gtttttgatg agcggtttgc
     1501 cctggcctac aacagtgctg tggtctcaga atgttcatat tgtggagccc cgtgggacca
     1561 atataaactc tgttctactc ctcaatgccg ccagcttgtg ttgacctgtt ctgcctgtca
     1621 aggacaagga ttcacagcct gttgtgtcat gtgtcaagac aaagggggca agcaggcttc
     1681 agaccccacc caggacagtt ttaaagaaga gtgtgagtgc acagcccgga ggccacgcat
     1741 tccgcaggag cagcgtgcgt gaccccctga gcctgggccc ggagcctgcg gctgctgagg
     1801 ctgaactgct cgttcagcag tcactggctt cacgacgtag agttacatag ccatgtgcag
     1861 atggtgaagg ttgtagaaac aaatggagag tgtccatgct ggtcactacc accctagcag
     1921 atagatggcc acagcaaagg accaggaagt ccagcgtagg ctacctaatt tacctgcttt
     1981 gattgagaag atgctagagc ctgggaaaag gtaaaccatg tgggatccca gtgttgatga
     2041 gagattgtct tgagcttggt ggctcctcgg ccgtgcagca gggaggcccc ggcgccactc
     2101 tagtcccctg tactgtccat agccttacag tttggtgtca gcaaaccttc accctggcag
     2161 caaaagtata aaagttgggc cctgggtatg gactcttaaa ccagaccagc ttctatctcc
     2221 ccctgcctca ttctcttccc tgactgcccg aaggctctgt ggctttgacc acctcgtgcc
     2281 ttggagcatt aatgaatctg ccaacccatc cctttatatg tgatcatggc actactgagt
     2341 agggccagag accacgtggc cttcagaatc taaagcaatt acactttgtt ccttcacgga
     2401 ggtctttgga aagaggtggc ccatgcttct attgattagg tttctttaaa gatggtcttc
     2461 taacagctct gcattcccca gcagtccctc tctctgcttg taagcatcct cagggatcca
     2521 gatgagcagc aggcttacgt cacatgtggc acacaggaca ttcattagtg agctcataca
     2581 gcacggtagc gacctaacct cctggccttt gggcacatgt tcctgtctca caattcttaa
     2641 gaagcacaca ggccatacat acaccaaatg gctttaatat tattttgcag tttccagtga
     2701 tgcagaatgc agctgcagtt gtgtttcaag gagaagctga gtggagctgg ctgtccctgc
     2761 agcttggtgc cactcctggg cctcagtgac cactcacagt gctgaggccc cgatgccact
     2821 ctagttaccc tgtgctgtcc atggccttac agtccggtgt gcaggtctta ggtcagaagc
     2881 ccctggctgt gctctgcagc ttttgagcca tcactgtcat atcggctgaa tccctaagga
     2941 aaacactccc caaagcaaca aaagtactag tttaactggc actgtggtct attaaaaggc
     3001 acaagaacag tgtattttaa catttttact ggctcccatg gtgttaaagg gatccagtag
     3061 gaatgccaag attaggtttc agaataattc cttgtgttgt atgtccagga tctcctaatt
     3121 ccttaccatt gggatgttgt actctgctgt ccttcagagg cttcgtgtgt gatttgattt
     3181 gtctcctaag tgaccgggca ggcacttggt gtctgtaagc agggccatgc taaataccac
     3241 aggcatggtg gactggaaat tcacccaatg gtgttgatct cacataagcc gttggctcac
     3301 tgcggtattg gaagatgttt ttatgtggtt gtaagttttc atccatcatg aagttggcat
     3361 tcaataaaga agaaatgatt tctgactaca
//
LOCUS       NM_001436973            5229 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus Myb/SANT DNA binding domain containing 3
            (Msantd3), transcript variant 3, mRNA.
ACCESSION   NM_001436973 XM_039110242
VERSION     NM_001436973.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5229)
  AUTHORS   Oleskevich,S., Leck,K.J., Matthaei,K. and Hendry,I.A.
  TITLE     Enhanced serotonin response in the hippocampus of Galphaz protein
            knock-out mice
  JOURNAL   Neuroreport 16 (9), 921-925 (2005)
   PUBMED   15931062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_039110242.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.21273.1,
                                           SRR26360186.1742771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000005.1  67661616-67661728
            114-564             JAXUCZ010000005.1  67673780-67674230
            565-5229            JAXUCZ010000005.1  67683307-67687971
FEATURES             Location/Qualifiers
     source          1..5229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5229
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT DNA binding domain containing 3"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
     exon            1..113
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="upstream in-frame stop codon"
     exon            114..564
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..974
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain containing 3"
                     /codon_start=1
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 3"
                     /protein_id="NP_001423902.1"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
                     /translation="MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIAL
                     KQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSGSPLLS
                     THVLDKEKIGSMLPEQLYFLQSPPEEEPEYHQDAAAQESFAVSNRELCDDEKEFVHFP
                     VCEGTSQPEPSCSAVRITANKNYRSKTPQEGALKKMHEEEHHQQMSILQLQLIQMNEV
                     HVAKIQQIERECEMAEEEHRIKMEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP"
     misc_feature    174..407
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     misc_feature    174..407
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     exon            565..5229
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaaaaggg ctcgcgctaa ctcgtgcggg tgactgccac atcccgggtg tgggaaaatg
       61 cgttcttttg ttgttggcgg agacgggccc cctttcgcag cttccgggcc aaggctagcc
      121 aacgaccagg agaaatagag tggaaaatgc aaaacaacga aatcattaaa cctgccaagt
      181 acttctcaga gctggagaag agcatcttgc ttgccttagt agagaagtac aagtatgtgc
      241 tggagtgcaa gaaaagcgac gcgcggacta ttgctctcaa gcagcggacc tggcaggcct
      301 tggcccatga gtacaactcg cagcccagcg tgtcgctgcg ggacttcaaa cagctgaaga
      361 agtgttggga gaacatcaag gctcggacca aaaaaattat ggcccacgag aggagggaga
      421 aggtgaagcg cagcgggagt ccgctgctga gcacgcacgt cctggacaag gagaagatcg
      481 gcagcatgct accggagcag ctctacttcc ttcagagccc gcccgaggag gagcccgagt
      541 accaccagga cgcagccgcc caagagtcct ttgctgtttc aaatcgagaa ctgtgcgacg
      601 atgagaaaga gtttgtccac tttcctgtat gtgaggggac ctcacaacct gaaccttcgt
      661 gttcagccgt cagaataaca gccaataaga actacaggag caaaacccct caggaaggtg
      721 ctttaaaaaa gatgcacgag gaggagcacc atcagcagat gtccatcctg cagctccagc
      781 tgatccagat gaatgaggtg cacgtggcca aaatccagca gatagaacgg gaatgtgaga
      841 tggccgagga ggaacaccgg atcaagatgg aggtcctcaa caagaagaag atgtactggg
      901 agagaaagct acagactttc accaaggagt ggcccgtctc ctcatttaac cgaccctttc
      961 ccaattcacc ctgagactgg gggatggctc cctgtagtta acctgtattg gcaaggcagt
     1021 gtgggatgtg gcctgcgtgg tcagtagccc gtgacagacc tacggctagg tgaattagag
     1081 tggtactagt cacttattaa gaacacattc aggtaaacag ctgcaccccg tctaccccta
     1141 aagtggccaa gaagctgtta cagtcttcta gaagtcacca ctacgcgtgc tataattctg
     1201 aatgtaatgt tcttaattag aattcataga ggaaccatgt gcgagtgttg tatttttttt
     1261 ttaagacatg caagtgtggt gatataggag tgaggctggt ggttctgacc tcatctgtca
     1321 gtggggtttt gtttgttttc agctgacagt ggcgcttttc cacacaggtg tgaagcccac
     1381 ccattgtgtg gctgtacctt ggctgtttct ccacctttca gtgtactctg agtgtgggcg
     1441 tttgaagagc ccagccttta gaagggtgtt tcctaatgtg ggttaccaac tgccttttta
     1501 gacttttccc cacagaggct ttccaaccag ggctccagcc gtggcggttt cagtagaagt
     1561 agggatgtaa caactggagg gcttaatgtt catttaggta tctacatcct gttggttttt
     1621 tattaaaaat gtcttaaaat tttatagtta cactgtgtat gtttttaaag gtgctgctat
     1681 cccagcccgg atccctccca actttttact gctgagtgaa tggttgtctg gactttttag
     1741 tctctcactc ccttaggaga ggccccgccc tcgctgtgtt catgctgtat gctggtgttg
     1801 accaccgatc agggttaggg tgaccaacat gtttggaaac gtggatggat aaatgggtgt
     1861 tttgatggag ctgtgatgtt tctgctgtaa cctgatgctt taaaaaaaat tttttttgtt
     1921 tttaagagtt gggacagtag tagctggagg cggcaggggg acccttaaga gccagtgttc
     1981 taagtgtggc tctggctaac tccctaaaac ctcaagctgg tgcttcctgt ccgcagaatg
     2041 agggagttga ggagacattt ggagcctgtt tcagctcctt agccacgttg cggcttgtgc
     2101 gactctctgc atgcactctg acttcatggc agcccggagg gcatgagtct acacagagtt
     2161 gtctctagaa atggccaagc tttggaattt ttcgtcccgg gcctgttagg ttttgtatgg
     2221 ttcacaccga ctcacagttt gtgcactgca tataatgtaa gcagatatca attttgtaca
     2281 ttgaatctat tttaaatatc ttagaggaat tagtccgtta ttttagatat atcctgcagt
     2341 gagagactag aagtaggatc cttccatgag gatttctgtc gttcattttt atcagatgaa
     2401 gccttcagag agtgaatggt ttgaaagtca cgttcgatgg tacgcagaag gtaggactcc
     2461 actccctgtg tcctgcctcc ggatagacag ggatggacag cacaaatcta ggtgcagagg
     2521 gctgcctttg cttcacgtac tgatctaaac atcctcttaa tatcacatcc agagtaaggc
     2581 atgaggtctg ttctcacaag ctcccagatt aggcctgatc tgatgctctg ctcaacacat
     2641 ctctgaatga caaggactta aagggacctt aggaagtttt ccatctctta catacataga
     2701 tgtggtggtt acgattttct aaaaattcat gacttaaact cacaaacagc cacatagaat
     2761 aacaaaaatt gcaacgcatt ttaattggac tataaaagca ttgaactaat tcctgtctga
     2821 acaaatacag gataattaag ccagagcata aaaccccttg ctgtactgct aatggtattt
     2881 atgagtttac aatagtagct tgcgatattt ggctatgtgt taggaataat attttataaa
     2941 taattagtcc cactgggtct cacttccaga gggttctgag tcagttgact tggggcgggg
     3001 ctggctgttg ggtatttttg gaagctttct aggtgattag gatgcagagt tgagattgag
     3061 agccactttg tacggcttac gaatgtattt cagttgcttc ttaattccac aaagccatgg
     3121 agaaggaagg aattgatgtt cggagaagag cccacctggc accaggcctg tagccagtaa
     3181 atagcaaaga agaacttcgg gctgggtctc ttggttccga gatgcacagc cccacctgct
     3241 gtctttaccc tttcttttga agccgagcca aggatgcttg attctgaggc tcgaatgacg
     3301 ttacacagtt gcttgctgaa gcagcttcat tcatgaacag acagcacatc ccagttcatt
     3361 ttgcttttga gctttttatt tcctgaggta gaaaagcaat aaccatttct tgacaggaat
     3421 cgtgggccag atacacataa aaaaatatta agacgtggtt ctacatcgtg ggcattgccc
     3481 gggagggagg gaagaatgga gggagggagg gctggttcgc agctggctgt agactcagcc
     3541 ggtgcacatc ttcaaatgct ctctcagttg agggcaggga gctaagaaaa tggagagcgg
     3601 aatcgtagaa gcgtggtatt tgagttgagt ctgtggggct gacattttgg caggtaggga
     3661 aagcagagaa catcaccaga tgacacacaa atgggagaga gaagagtgag ctagagggga
     3721 gttttcaaat ctgatcagaa ccgtgcacca ggagggaagt tagaagctgg aatggagggg
     3781 agaggagact gcagttggga tgacaggaag gagggcttgg ctttggtagc cgggatgaca
     3841 ggatccagag gaggtcgtgg aaaggagacc agggtcctga gcgagtggat ggtgattgtt
     3901 tttgttagag aggagtggaa ggtgttcaca gctagacttg tgagagaaca atactgataa
     3961 taaccccgaa atgaggggac gatacaaatg tcctctagga tatttgatgt cctagatgtg
     4021 cctaggcaca gacactggta tttgctccca attctttgtc tacctcatct ctgcagcgac
     4081 ttcctccttg tcacctgctg ttgttccttc tgcctgttca cttgaactgg ccctactcag
     4141 tcctcggtca cctgactatt tggtacttcc tctgtctcca atccctccat tgttattagg
     4201 ggcacctcat tcagtatcgt ctatgtcggg ttgcactaag atggccagag gacgttgctc
     4261 tttgttgttt gtttttgatt tttgtttttg tcttcgtttt tggtcccaag ttgaataaca
     4321 aatccgtggc tggaaaagat tggtgacttc catgtttgca tatcacagcc ctttaaaaaa
     4381 aatcaaatat ggaaccctac ccaatgggtc catgctttag gaatgtttca agggagatgc
     4441 caggacaatc tttagatgca ttttcttttg tttcgcttca gggggcagag atggcatggt
     4501 aggagaatgc attggagttg tcaacagtct ctgccgtgtc aggtcaatta catcagcact
     4561 tggtctagac cagaggaaag gaatgattgt gcctcctggg aatgtcacaa ggacctgata
     4621 attatatttg gcaaagccat gaggagtggc tcgtaatgtc attactaaga attacccttt
     4681 cagtagcatt tctggacgcc tgagctttgc acagggatgg tacttcattt ctgtgccttc
     4741 cttcctgctg ggcctcttcc caggtggtcc ccctactccc cctgcccttg ctggctggct
     4801 gtattctccc tccaacccaa tccccacctc ccaagcccac cttctgccct cacagtcgct
     4861 ttcactgtcc agtggtagag gtgaaagcta catgggatgc tcttcctgcg gatgcccaga
     4921 gggcagctcc ctcagctcct gcggcagccc ctggacagag ctgatttatt tccatgctgc
     4981 agtcgctacc tttgtctacc tttgtgctcg tgggactcaa agagtcgtgg gaaaggtgac
     5041 caggaacctg tgacagcaac cagttctttc ccgactgtgc catatattat gctcttccac
     5101 acagtttact aatctctgcc tcagtttctc catctgtaag tgatgtaata cttatctacc
     5161 tcccttggat gttgtgaaga ttagtatgtg ttggtaaagc acttctgaaa taaagaatga
     5221 taccaagca
//
LOCUS       NM_001436970            1048 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 9, mRNA.
ACCESSION   NM_001436970
VERSION     NM_001436970.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1048)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO768849.1, SRR26360176.573906.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840132,
                                           SAMN16676784 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000005.1  65211224-65211292   c
            70-274              JAXUCZ010000005.1  65207932-65208136   c
            275-588             JAXUCZ010000005.1  65204444-65204757   c
            589-709             JAXUCZ010000005.1  65202357-65202477   c
            710-835             JAXUCZ010000005.1  65198348-65198473   c
            836-1048            JAXUCZ010000005.1  65197446-65197658   c
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1048
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..69
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            70..274
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             110..1012
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform c is encoded by transcript variant 9;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform c"
                     /protein_id="NP_001423899.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGMLMFYRSVTLRHRYKVYKKVKY"
     misc_feature    614..>910
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    614..>910
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     exon            275..588
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            589..709
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            710..835
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1048
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggctcca gggcggggag cagcgccaag ttggagaagg gagacccagg aaaggcctag
       61 gtattgcgga tacttgactg aaagggatcc atcccactga taaaaccaga tgccttctcc
      121 cacttcagca gacgaagagg atggcctgga gacctgtgtt ttaaagactt ttgatctgga
      181 tttaaaagaa tcaaatattg ttactccaag caatagtctc aaagcagagt tagatggcag
      241 tacaaagaag aaatactcgt ttgcaaagaa aaaggccttt gccctttttg tcaaaaccaa
      301 acaagttcca gtgccttctt atgaagttaa ggaaagacgg tggcgatgtt gtcagcagct
      361 gtttgcagag cagaccagca tccacagaca tgtggccaca cagcacgctg aagacgtgta
      421 ccagcagact gcttccattc tcaagcagct cactgcagca ctgaggaccc cacagagtct
      481 tacgcccaca gaccggagga gctccccaaa agactgtctc cctcctagtc aggatgtgtc
      541 tgcttggctc cctgatgtga gccacgttag cccgcaagag ctgaggagtg gccagggcaa
      601 tgaggaagga gaggtgctcc tgtattactg ctactgtgac ttggaggacc ccgactgggt
      661 ctgtgcctgg caggcagctc tgtgccgtca cctgcacctt acaggcaaga ttcggatcgc
      721 gacagaagga atcaatggaa ccgttggagg aagcaaagtg gccacccgac tctacatgga
      781 agtcatgctt tcttgcccat tatttaagga ttacctgagc gaggatgatt ttaagagcag
      841 caaaggaggg tctcactgct tcccggaatt gcgagtcggt gtgttcgaag agatcgtgcc
      901 catggggatc agccccagtg aggtctccta caagaacccc ggtatgctta tgttttacag
      961 aagtgttact cttcgtcata gatataaagt gtataagaaa gttaaatact gattagcaaa
     1021 aactgtaata aaccttctct ttaaaata
//
LOCUS       NM_001437010            5842 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 7, mRNA.
ACCESSION   NM_001437010
VERSION     NM_001437010.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5842)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5842)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5842)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5842)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5842)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5842)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5842)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5842)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5842)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5842)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.21333.1,
                                           SRR26643297.18991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000005.1  73135386-73135393
            9-81                JAXUCZ010000005.1  73141847-73141919
            82-284              JAXUCZ010000005.1  73142997-73143199
            285-344             JAXUCZ010000005.1  73151592-73151651
            345-548             JAXUCZ010000005.1  73152711-73152914
            549-826             JAXUCZ010000005.1  73158194-73158471
            827-959             JAXUCZ010000005.1  73160426-73160558
            960-1089            JAXUCZ010000005.1  73165478-73165607
            1090-1223           JAXUCZ010000005.1  73169494-73169627
            1224-1351           JAXUCZ010000005.1  73170920-73171047
            1352-5842           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5842
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..8
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            9..81
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            82..284
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1565
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 7;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423939.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    180..1013
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    180..1013
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1044..>1160
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1044..>1160
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            285..344
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            345..548
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            549..826
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            827..959
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1089
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1223
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1351
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..5842
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttagct gcagaggtga gtgggcaaag agtatggcaa tagagtcacc gtgggacact
       61 ggagtaaaag cgaaataaca gaagtacctc tgttgacagg aaacaagatt ctgtttcata
      121 aagaagatga aaacaactgg gttcctgtta acaaacaccc aagagaccag catagaccaa
      181 tgagcagagt caataagaac gtggtcttgg cccttctaac actgatgagc tgtgccttcc
      241 tgctgtttca gctgtactac tacaagcact acttgtcagc acggaatgga acgggttcat
      301 caaaatccaa aggaaatcga gttggatttg atagcacaca atggcgtgca gttaagaaat
      361 ttattatgct gacatccagc caaaatgtgc cggtgttcct tattgaccct tggattctgg
      421 aatcaattaa taaaaatttc gaacaagtga aaaatgcctc tcaaggctcg gcctcagaat
      481 gcagattttt ctgtgttccg agagacttca ctgcgttcgc gctgcagtat cacctgtgga
      541 agaatgagga tggatggttt cagatggctg agaacatggg attccagtgc ctgaagattg
      601 aaagcaaaga tcctcggctg gatggaatag actcgctttc cggaactgag atccctctgc
      661 actatgtctg taagctggcc actcacgcca tccacttggt cgtctttcac gagaggagtg
      721 gcaactacct ctggcatggt cacctacgac tcaaagggca catggatagg aagtttgttc
      781 cttttcgaag gctacaattt ggtcgttatc ctggagcctt tgacaggccg gagttacagc
      841 aggttactgt tgatggactc gacatgctta ttccaaaaga cccagggcgc tttctagaag
      901 aagtacctca ctccagattt atcgagtgca ggtataaaga agcccgggca ttccttcagc
      961 agtacgtcga tgacaacact gtggatgcca tggcctttcg gaagagggca aaggagttac
     1021 tgcaactagc ggccaagacg ctgaaggcgc tgggagtgcc cttctggctg agcagtggga
     1081 cgtgtctagg atggtatcgg caatgcagta tcattcctta tagcaaagat gtcgacctag
     1141 gaattttcat tcaagattac aaacctgata ttgttttggc atttcaggat gcaggacttc
     1201 cactcaaaca caagtttggg aaggtggagg acagcttgga actctccttc cagggacaag
     1261 ctgatgtaaa acttgatatt tttttcttct atgaagagac tgaccatatg tggaatggag
     1321 gcacgcaggc cagaacagga aagaagttta agtatctgtt ccccaagttt acactgtgct
     1381 ggacggagtt tgtagacata aaagtccatg ttccctgtga aacagttgac tacattgaag
     1441 ccaactatgg caaggcctgg aagatccctg tcaagacctg ggactggaag agctcacccc
     1501 cgaatgtgca gcccaatggg gtctggccta tttcggagtg ggatgaagtt atccagttgt
     1561 actgagaaca ctgagctcat gtgggacgtt tcccagaaag aaggtaggca gctgttgaaa
     1621 gcactatgtt ttctgcctga tgtgagagcc aaagaggaga aatgacgagt tggaagacag
     1681 aaaaggtttt ctgactcatg ggccatctaa tcagttctgc cactcagcat ttactgagga
     1741 gtttatacac caggtgaagt actaggatct ggtgaacagg cagagaggaa tgagaggcca
     1801 gcttctctct tgccctgttg gtaagcacta caattttatg ttaagggaaa ctaacccact
     1861 ctctgaagag gtgtacagta gaatgtattc cataatgatt tttaaaatgt taattaatgt
     1921 ttaaaccgga aagtgagctc atcagacaaa gctaacaaag gatgtgttag ttgagagtag
     1981 ttcatttctg cctgccctcg ggatttaagc tgctgtgtta gtgttaaggt tgtgggatat
     2041 gagttaatat tccagtgagt gattagactt tgtctcacag agaaaagaca gtggccaact
     2101 cattttacaa gcagtgtgat acacagttga cttcaagcac tgggcattct ataagggagg
     2161 atgagagccg atagcagctc ttgtcaagac gtacactgtt ttcatctttg agatgaacat
     2221 ggatgcttag atggtgcttg aatccctgac atcataagga tattttcact gacctgcagt
     2281 agtacttcct gataaatcat tcagtcgtgc tatccaaaag ttgtgacatc tcaaagcttc
     2341 cgttccttat ttcattctta gtcactctta aactcaaaaa tggaagttac tcatgaatat
     2401 ttttatattt tatgaatgta taacttttct gcctttaatt ttaatattga cactaagtaa
     2461 taatagacat acctcttaat tttttaaaaa taccctttat ttatttatca accatagttc
     2521 catgtgttta atttatggcc tacacactaa tttatttagc acaagatatg cctgttcttc
     2581 tatccaatat tacttcacgg ttccaaaatg aagggttaac gtgaacctgg ccattactcc
     2641 ttttcccaga ttactgtctt taaagcctgt gtccatctct agattttcat tctgctgagt
     2701 gtaatagggc aagggcttcc tacccacaag tactgcacaa gtgggaccct tgacctacac
     2761 tcctgagtcc attgtagtgg ctgcacataa gccatgcagt ctcagagaga gatgacacag
     2821 tgagtgcctg cctgccttgc ctgggagggg agggtccact ccctgctgct tagggatgtg
     2881 cttcatggca acctggcaga tttcccttgg cacgtgtagt tactacagca gaaaccagga
     2941 tagatgagag aatgggctgg cagaaagaaa agaaaaaaga aagaaaaaga aaaacttgga
     3001 ggaagtaact tgaagccacc tatttccaaa tttaaacttc aacatgaaaa ctgtctttgt
     3061 tggatgatat gcagcagtct ccatgcagcc tccaagtagg aatattgtct ctccataagc
     3121 atcatctaat cagagtgtta cagttattag cacacatgta cccaaatgac aaatcataat
     3181 cagctctttc ctagaaaata agtccataga atacgtaccc aagttgtaga tacccaaccc
     3241 tacatatttt tctgtgtgcg catgcgtgtg cacgcacaca cccccactcg cacacaccag
     3301 ataatagtgt ttttgaggac aaacccaccc tacctggaga ggatcattta cttgtactca
     3361 atatcaagaa gtatgtttat atcgtgttcc ttgagagctc ccaccttctg ccaggagatc
     3421 ttacccaccc ctgtttaagt ttcttctctc atacctgtcg ttggagtgca aggtctgcca
     3481 gtgtccataa tacaagctct tggtcctggg cacagaggtt ctgtagtctt cccttcatag
     3541 aggatgggta cctgttttcc ctctggtttg gctttaggtt ttaggttccg cccaccgtgg
     3601 agaaattttc ccagaatttg caggtgaggt ttacctctaa aaatgactcc atgattcagt
     3661 catactgaag tcagtgcttc ttaactcttg aactctgctg agtgtcccga gatcttgggt
     3721 caggtctgcc caccacctga accttttcag atcacttctc ttccctccct gaatatgcta
     3781 actgttattc tcctaatatg agtgctttct ggtcccattt gcctggactg cttgaagata
     3841 cctttacatt aactcattgg tagttctgct gccgaggatc tttcagaggg accctgagaa
     3901 gcagatgctt tctcggttta cgacagccat ctacttccct aagcgtggag gacttgcccc
     3961 gctcttggtt acagttactg acattggcca ctgagatgaa ataatagtaa ctaaaactgg
     4021 cctccctgag agtacctgag atccgttctt agtgtggcct ccatgacact ccagtgcttg
     4081 gtgagtcctc cagtgcctca gtgcctgcca ttccccacgg aaggcctgag gcgacagaaa
     4141 atgctgagga gggatgtttc ctcttgtcca gaattctcag gctaccgtct cacctttgtc
     4201 tggggagggt tcaggaggtg ggccaaggga ggggaagcct tatctacaaa aaatagaaca
     4261 gtttatgtct gaagacatca ccagaagtca gtttctgact cttgaaatgt ttaaaggatt
     4321 taatgatgca tacagtgctt ccattcaggc ccagcgttaa gtaagtactc gccatttcct
     4381 agttctcggt tcctttgtaa cgtggaaggc tgcacgacag agttgcttag aactaaaatt
     4441 ggggcactgc tgagatggct tagcaggcaa aagcccttgt caccaaaagt gacatgagtt
     4501 tgattcccag gacccatgta atggaaggaa agaatctcaa attgcttgtc atccaataca
     4561 cagactctga tgtgcttgga gctcctctct agcatgagag gacaccacac acacacacac
     4621 acacacacac acacacacac acacacacac acacacacac acacactaag taaatataat
     4681 ggaaagtttt tattttatct aagcattaca ggtcgaatta tgtgattttt gagtcattgc
     4741 catattccct ccacctgaaa cagagctggt tctcacttag ttgaccaagt ggttgtcttc
     4801 taatcctatc ctattgtact atacccttta agcacagtca gattgctctt aagttttgtg
     4861 ccttgatttt caatagtcca gctttgggca gctaacatca ctatatataa tgatttggag
     4921 aaccaaagat tttggaatgc ttagttttat ttacctgcct agtctgtata gaaatgtggg
     4981 ctagttagtc taattgccca gcatgtgtga ggtctggatt cagtacaaag caccagaagt
     5041 ctgagacaga agacttagca catgctgaag gccagcttgg gctacctagt gagtaccagc
     5101 ctatcctggg ctacagtgta agaccctata ttgattgagg acacaggagg gaagagagaa
     5161 acagagacag aatgagaata tactcctgtc agccatctgc ccatagatgt atgttttaat
     5221 ctaagcgagg caaaatcagg atatatagtg tggattttta aatagttaat tgtagacaat
     5281 taacagccaa ttcgatattg atgctttttg tataggacca ataggcaagt gtaatgtgtt
     5341 gagaaacgta tttccaaaca ctcagaacac ctaggctaaa gcctgctcct gtaactcctg
     5401 gacctaacgt agaaggatcg aagaatctct gtgagggagg gcccatgtag tgacgcagac
     5461 ttccgtctac ttatgagtaa ctttcgcgga agggaaagct ttgtcatata aagtattctg
     5521 tcaagcgctt taagaatgat aagcctgtac aaacttatga caatgtgttc taagcatggg
     5581 aaccagttca tgagtttgtt aaatgtagtt ctgtcaacat gggacatatg acgatgacat
     5641 gtgtattgta tgtgaacttt ctagacaaag ttatgtttta aacaagataa aactggtata
     5701 tgcttaccag gttaagattt ggttttgtcc tcaggtatag tttatggtac tactgaaata
     5761 gttttaatgt tattactctg atctgaattt gtaatatata gtctactttg ggatgattaa
     5821 taaaaatttt taatctcttg tg
//
LOCUS       NM_001437007            6134 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 5, mRNA.
ACCESSION   NM_001437007 XM_008763712
VERSION     NM_001437007.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6134)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6134)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6134)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 6134)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 6134)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 6134)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 6134)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 6134)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 6134)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 6134)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_008763712.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18992.1,
                                           SRR26360176.1245506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  73135386-73135548
            164-373             JAXUCZ010000005.1  73140265-73140474
            374-576             JAXUCZ010000005.1  73142997-73143199
            577-636             JAXUCZ010000005.1  73151592-73151651
            637-840             JAXUCZ010000005.1  73152711-73152914
            841-1118            JAXUCZ010000005.1  73158194-73158471
            1119-1251           JAXUCZ010000005.1  73160426-73160558
            1252-1381           JAXUCZ010000005.1  73165478-73165607
            1382-1515           JAXUCZ010000005.1  73169494-73169627
            1516-1643           JAXUCZ010000005.1  73170920-73171047
            1644-6134           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..6134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6134
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..163
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            164..373
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    355..357
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            374..576
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1857
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 5;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423936.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    472..1305
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    472..1305
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1336..>1452
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1336..>1452
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            577..636
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            637..840
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1118
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1251
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1381
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1515
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1643
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..6134
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg cagattcaga ttgtgtgtgt
      181 ggattgtttc aaagctccgc acaaagactt aggactttaa ttaaaatggc agagtgaaaa
      241 tacttgtact ttattcaatc tgaagttacc ctgaaaaaaa catgaaaaat ggaagatgga
      301 tcttaacaca gcttccccaa cgcaaatatt gctgtgaccc caaactgaaa tgtttgagag
      361 gtggttgcca cagaagtacc tctgttgaca ggaaacaaga ttctgtttca taaagaagat
      421 gaaaacaact gggttcctgt taacaaacac ccaagagacc agcatagacc aatgagcaga
      481 gtcaataaga acgtggtctt ggcccttcta acactgatga gctgtgcctt cctgctgttt
      541 cagctgtact actacaagca ctacttgtca gcacggaatg gaacgggttc atcaaaatcc
      601 aaaggaaatc gagttggatt tgatagcaca caatggcgtg cagttaagaa atttattatg
      661 ctgacatcca gccaaaatgt gccggtgttc cttattgacc cttggattct ggaatcaatt
      721 aataaaaatt tcgaacaagt gaaaaatgcc tctcaaggct cggcctcaga atgcagattt
      781 ttctgtgttc cgagagactt cactgcgttc gcgctgcagt atcacctgtg gaagaatgag
      841 gatggatggt ttcagatggc tgagaacatg ggattccagt gcctgaagat tgaaagcaaa
      901 gatcctcggc tggatggaat agactcgctt tccggaactg agatccctct gcactatgtc
      961 tgtaagctgg ccactcacgc catccacttg gtcgtctttc acgagaggag tggcaactac
     1021 ctctggcatg gtcacctacg actcaaaggg cacatggata ggaagtttgt tccttttcga
     1081 aggctacaat ttggtcgtta tcctggagcc tttgacaggc cggagttaca gcaggttact
     1141 gttgatggac tcgacatgct tattccaaaa gacccagggc gctttctaga agaagtacct
     1201 cactccagat ttatcgagtg caggtataaa gaagcccggg cattccttca gcagtacgtc
     1261 gatgacaaca ctgtggatgc catggccttt cggaagaggg caaaggagtt actgcaacta
     1321 gcggccaaga cgctgaaggc gctgggagtg cccttctggc tgagcagtgg gacgtgtcta
     1381 ggatggtatc ggcaatgcag tatcattcct tatagcaaag atgtcgacct aggaattttc
     1441 attcaagatt acaaacctga tattgttttg gcatttcagg atgcaggact tccactcaaa
     1501 cacaagtttg ggaaggtgga ggacagcttg gaactctcct tccagggaca agctgatgta
     1561 aaacttgata tttttttctt ctatgaagag actgaccata tgtggaatgg aggcacgcag
     1621 gccagaacag gaaagaagtt taagtatctg ttccccaagt ttacactgtg ctggacggag
     1681 tttgtagaca taaaagtcca tgttccctgt gaaacagttg actacattga agccaactat
     1741 ggcaaggcct ggaagatccc tgtcaagacc tgggactgga agagctcacc cccgaatgtg
     1801 cagcccaatg gggtctggcc tatttcggag tgggatgaag ttatccagtt gtactgagaa
     1861 cactgagctc atgtgggacg tttcccagaa agaaggtagg cagctgttga aagcactatg
     1921 ttttctgcct gatgtgagag ccaaagagga gaaatgacga gttggaagac agaaaaggtt
     1981 ttctgactca tgggccatct aatcagttct gccactcagc atttactgag gagtttatac
     2041 accaggtgaa gtactaggat ctggtgaaca ggcagagagg aatgagaggc cagcttctct
     2101 cttgccctgt tggtaagcac tacaatttta tgttaaggga aactaaccca ctctctgaag
     2161 aggtgtacag tagaatgtat tccataatga tttttaaaat gttaattaat gtttaaaccg
     2221 gaaagtgagc tcatcagaca aagctaacaa aggatgtgtt agttgagagt agttcatttc
     2281 tgcctgccct cgggatttaa gctgctgtgt tagtgttaag gttgtgggat atgagttaat
     2341 attccagtga gtgattagac tttgtctcac agagaaaaga cagtggccaa ctcattttac
     2401 aagcagtgtg atacacagtt gacttcaagc actgggcatt ctataaggga ggatgagagc
     2461 cgatagcagc tcttgtcaag acgtacactg ttttcatctt tgagatgaac atggatgctt
     2521 agatggtgct tgaatccctg acatcataag gatattttca ctgacctgca gtagtacttc
     2581 ctgataaatc attcagtcgt gctatccaaa agttgtgaca tctcaaagct tccgttcctt
     2641 atttcattct tagtcactct taaactcaaa aatggaagtt actcatgaat atttttatat
     2701 tttatgaatg tataactttt ctgcctttaa ttttaatatt gacactaagt aataatagac
     2761 atacctctta attttttaaa aatacccttt atttatttat caaccatagt tccatgtgtt
     2821 taatttatgg cctacacact aatttattta gcacaagata tgcctgttct tctatccaat
     2881 attacttcac ggttccaaaa tgaagggtta acgtgaacct ggccattact ccttttccca
     2941 gattactgtc tttaaagcct gtgtccatct ctagattttc attctgctga gtgtaatagg
     3001 gcaagggctt cctacccaca agtactgcac aagtgggacc cttgacctac actcctgagt
     3061 ccattgtagt ggctgcacat aagccatgca gtctcagaga gagatgacac agtgagtgcc
     3121 tgcctgcctt gcctgggagg ggagggtcca ctccctgctg cttagggatg tgcttcatgg
     3181 caacctggca gatttccctt ggcacgtgta gttactacag cagaaaccag gatagatgag
     3241 agaatgggct ggcagaaaga aaagaaaaaa gaaagaaaaa gaaaaacttg gaggaagtaa
     3301 cttgaagcca cctatttcca aatttaaact tcaacatgaa aactgtcttt gttggatgat
     3361 atgcagcagt ctccatgcag cctccaagta ggaatattgt ctctccataa gcatcatcta
     3421 atcagagtgt tacagttatt agcacacatg tacccaaatg acaaatcata atcagctctt
     3481 tcctagaaaa taagtccata gaatacgtac ccaagttgta gatacccaac cctacatatt
     3541 tttctgtgtg cgcatgcgtg tgcacgcaca cacccccact cgcacacacc agataatagt
     3601 gtttttgagg acaaacccac cctacctgga gaggatcatt tacttgtact caatatcaag
     3661 aagtatgttt atatcgtgtt ccttgagagc tcccaccttc tgccaggaga tcttacccac
     3721 ccctgtttaa gtttcttctc tcatacctgt cgttggagtg caaggtctgc cagtgtccat
     3781 aatacaagct cttggtcctg ggcacagagg ttctgtagtc ttcccttcat agaggatggg
     3841 tacctgtttt ccctctggtt tggctttagg ttttaggttc cgcccaccgt ggagaaattt
     3901 tcccagaatt tgcaggtgag gtttacctct aaaaatgact ccatgattca gtcatactga
     3961 agtcagtgct tcttaactct tgaactctgc tgagtgtccc gagatcttgg gtcaggtctg
     4021 cccaccacct gaaccttttc agatcacttc tcttccctcc ctgaatatgc taactgttat
     4081 tctcctaata tgagtgcttt ctggtcccat ttgcctggac tgcttgaaga tacctttaca
     4141 ttaactcatt ggtagttctg ctgccgagga tctttcagag ggaccctgag aagcagatgc
     4201 tttctcggtt tacgacagcc atctacttcc ctaagcgtgg aggacttgcc ccgctcttgg
     4261 ttacagttac tgacattggc cactgagatg aaataatagt aactaaaact ggcctccctg
     4321 agagtacctg agatccgttc ttagtgtggc ctccatgaca ctccagtgct tggtgagtcc
     4381 tccagtgcct cagtgcctgc cattccccac ggaaggcctg aggcgacaga aaatgctgag
     4441 gagggatgtt tcctcttgtc cagaattctc aggctaccgt ctcacctttg tctggggagg
     4501 gttcaggagg tgggccaagg gaggggaagc cttatctaca aaaaatagaa cagtttatgt
     4561 ctgaagacat caccagaagt cagtttctga ctcttgaaat gtttaaagga tttaatgatg
     4621 catacagtgc ttccattcag gcccagcgtt aagtaagtac tcgccatttc ctagttctcg
     4681 gttcctttgt aacgtggaag gctgcacgac agagttgctt agaactaaaa ttggggcact
     4741 gctgagatgg cttagcaggc aaaagccctt gtcaccaaaa gtgacatgag tttgattccc
     4801 aggacccatg taatggaagg aaagaatctc aaattgcttg tcatccaata cacagactct
     4861 gatgtgcttg gagctcctct ctagcatgag aggacaccac acacacacac acacacacac
     4921 acacacacac acacacacac acacacacac acacacacta agtaaatata atggaaagtt
     4981 tttattttat ctaagcatta caggtcgaat tatgtgattt ttgagtcatt gccatattcc
     5041 ctccacctga aacagagctg gttctcactt agttgaccaa gtggttgtct tctaatccta
     5101 tcctattgta ctataccctt taagcacagt cagattgctc ttaagttttg tgccttgatt
     5161 ttcaatagtc cagctttggg cagctaacat cactatatat aatgatttgg agaaccaaag
     5221 attttggaat gcttagtttt atttacctgc ctagtctgta tagaaatgtg ggctagttag
     5281 tctaattgcc cagcatgtgt gaggtctgga ttcagtacaa agcaccagaa gtctgagaca
     5341 gaagacttag cacatgctga aggccagctt gggctaccta gtgagtacca gcctatcctg
     5401 ggctacagtg taagacccta tattgattga ggacacagga gggaagagag aaacagagac
     5461 agaatgagaa tatactcctg tcagccatct gcccatagat gtatgtttta atctaagcga
     5521 ggcaaaatca ggatatatag tgtggatttt taaatagtta attgtagaca attaacagcc
     5581 aattcgatat tgatgctttt tgtataggac caataggcaa gtgtaatgtg ttgagaaacg
     5641 tatttccaaa cactcagaac acctaggcta aagcctgctc ctgtaactcc tggacctaac
     5701 gtagaaggat cgaagaatct ctgtgaggga gggcccatgt agtgacgcag acttccgtct
     5761 acttatgagt aactttcgcg gaagggaaag ctttgtcata taaagtattc tgtcaagcgc
     5821 tttaagaatg ataagcctgt acaaacttat gacaatgtgt tctaagcatg ggaaccagtt
     5881 catgagtttg ttaaatgtag ttctgtcaac atgggacata tgacgatgac atgtgtattg
     5941 tatgtgaact ttctagacaa agttatgttt taaacaagat aaaactggta tatgcttacc
     6001 aggttaagat ttggttttgt cctcaggtat agtttatggt actactgaaa tagttttaat
     6061 gttattactc tgatctgaat ttgtaatata tagtctactt tgggatgatt aataaaaatt
     6121 tttaatctct tgtg
//
LOCUS       NM_001108663            3384 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 2, mRNA.
ACCESSION   NM_001108663 XM_001071828 XM_342832
VERSION     NM_001108663.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001108663.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.21183.1,
                                           SRR26643287.13162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000005.1  65211340-65211573   c
            235-439             JAXUCZ010000005.1  65207932-65208136   c
            440-753             JAXUCZ010000005.1  65204444-65204757   c
            754-874             JAXUCZ010000005.1  65202357-65202477   c
            875-1000            JAXUCZ010000005.1  65198348-65198473   c
            1001-1106           JAXUCZ010000005.1  65197553-65197658   c
            1107-1225           JAXUCZ010000005.1  65194234-65194352   c
            1226-1384           JAXUCZ010000005.1  65193640-65193798   c
            1385-1523           JAXUCZ010000005.1  65192934-65193072   c
            1524-3384           JAXUCZ010000005.1  65188829-65190689   c
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..234
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            235..439
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             275..1756
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform a is encoded by transcript variant 2;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform a"
                     /protein_id="NP_001102133.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSECSYCGAPWDQYKLCSTPQCRQLVLTCSACQGQG
                     FTACCVMCQDKGGKQASDPTQDSFKEECECTARRPRIPQEQRA"
     misc_feature    779..1651
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    779..1651
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    1334..1336
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     misc_feature    1334..1336
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     exon            440..753
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1000
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1106
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1225
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1523
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..3384
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcacgacg cctgccggaa gcgcgagcgg agaggcaccg gatgggtttc gcggtggaag
       61 gccggcgtct gcaagtccaa gctcagccgc ctcctccggc tttccactct gggaccttcc
      121 ggacggcgag ctaaattatc cgggctgcaa cgatcccgcc tcagctttgc acaggcccag
      181 cagtattttc ccggcggccc ctgcgccgac gactttggag acttccggag atagatactt
      241 gactgaaagg gatccatccc actgataaaa ccagatgcct tctcccactt cagcagacga
      301 agaggatggc ctggagacct gtgttttaaa gacttttgat ctggatttaa aagaatcaaa
      361 tattgttact ccaagcaata gtctcaaagc agagttagat ggcagtacaa agaagaaata
      421 ctcgtttgca aagaaaaagg cctttgccct ttttgtcaaa accaaacaag ttccagtgcc
      481 ttcttatgaa gttaaggaaa gacggtggcg atgttgtcag cagctgtttg cagagcagac
      541 cagcatccac agacatgtgg ccacacagca cgctgaagac gtgtaccagc agactgcttc
      601 cattctcaag cagctcactg cagcactgag gaccccacag agtcttacgc ccacagaccg
      661 gaggagctcc ccaaaagact gtctccctcc tagtcaggat gtgtctgctt ggctccctga
      721 tgtgagccac gttagcccgc aagagctgag gagtggccag ggcaatgagg aaggagaggt
      781 gctcctgtat tactgctact gtgacttgga ggaccccgac tgggtctgtg cctggcaggc
      841 agctctgtgc cgtcacctgc accttacagg caagattcgg atcgcgacag aaggaatcaa
      901 tggaaccgtt ggaggaagca aagtggccac ccgactctac atggaagtca tgctttcttg
      961 cccattattt aaggattacc tgagcgagga tgattttaag agcagcaaag gagggtctca
     1021 ctgcttcccg gaattgcgag tcggtgtgtt cgaagagatc gtgcccatgg ggatcagccc
     1081 cagtgaggtc tcctacaaga accccggaat ccatttatcc cctggagaat ttcataaaga
     1141 aatagaaaaa ctattgtcac aggcaaatca ggaacaaggt gatactctcc tactggactg
     1201 caggaacttc tatgaaagca aaataggacg attccagggc tgcttagcac cagacatcag
     1261 gaagttcagt tacttcccta gctacgttga caaaaacctt gacattttca ggcagaagag
     1321 ggtgctgatg tactgcactg ggggcattcg ctgcgaacgg ggttctgcat acctcagagc
     1381 caagggagtg tgtaaggaag tgtttcagct caagggtggc atccacaagt atctagaaga
     1441 gtttcctgat ggatttttca aagggaagct gtttgttttt gatgagcggt ttgccctggc
     1501 ctacaacagt gctgtggtct cagaatgttc atattgtgga gccccgtggg accaatataa
     1561 actctgttct actcctcaat gccgccagct tgtgttgacc tgttctgcct gtcaaggaca
     1621 aggattcaca gcctgttgtg tcatgtgtca agacaaaggg ggcaagcagg cttcagaccc
     1681 cacccaggac agttttaaag aagagtgtga gtgcacagcc cggaggccac gcattccgca
     1741 ggagcagcgt gcgtgacccc ctgagcctgg gcccggagcc tgcggctgct gaggctgaac
     1801 tgctcgttca gcagtcactg gcttcacgac gtagagttac atagccatgt gcagatggtg
     1861 aaggttgtag aaacaaatgg agagtgtcca tgctggtcac taccacccta gcagatagat
     1921 ggccacagca aaggaccagg aagtccagcg taggctacct aatttacctg ctttgattga
     1981 gaagatgcta gagcctggga aaaggtaaac catgtgggat cccagtgttg atgagagatt
     2041 gtcttgagct tggtggctcc tcggccgtgc agcagggagg ccccggcgcc actctagtcc
     2101 cctgtactgt ccatagcctt acagtttggt gtcagcaaac cttcaccctg gcagcaaaag
     2161 tataaaagtt gggccctggg tatggactct taaaccagac cagcttctat ctccccctgc
     2221 ctcattctct tccctgactg cccgaaggct ctgtggcttt gaccacctcg tgccttggag
     2281 cattaatgaa tctgccaacc catcccttta tatgtgatca tggcactact gagtagggcc
     2341 agagaccacg tggccttcag aatctaaagc aattacactt tgttccttca cggaggtctt
     2401 tggaaagagg tggcccatgc ttctattgat taggtttctt taaagatggt cttctaacag
     2461 ctctgcattc cccagcagtc cctctctctg cttgtaagca tcctcaggga tccagatgag
     2521 cagcaggctt acgtcacatg tggcacacag gacattcatt agtgagctca tacagcacgg
     2581 tagcgaccta acctcctggc ctttgggcac atgttcctgt ctcacaattc ttaagaagca
     2641 cacaggccat acatacacca aatggcttta atattatttt gcagtttcca gtgatgcaga
     2701 atgcagctgc agttgtgttt caaggagaag ctgagtggag ctggctgtcc ctgcagcttg
     2761 gtgccactcc tgggcctcag tgaccactca cagtgctgag gccccgatgc cactctagtt
     2821 accctgtgct gtccatggcc ttacagtccg gtgtgcaggt cttaggtcag aagcccctgg
     2881 ctgtgctctg cagcttttga gccatcactg tcatatcggc tgaatcccta aggaaaacac
     2941 tccccaaagc aacaaaagta ctagtttaac tggcactgtg gtctattaaa aggcacaaga
     3001 acagtgtatt ttaacatttt tactggctcc catggtgtta aagggatcca gtaggaatgc
     3061 caagattagg tttcagaata attccttgtg ttgtatgtcc aggatctcct aattccttac
     3121 cattgggatg ttgtactctg ctgtccttca gaggcttcgt gtgtgatttg atttgtctcc
     3181 taagtgaccg ggcaggcact tggtgtctgt aagcagggcc atgctaaata ccacaggcat
     3241 ggtggactgg aaattcaccc aatggtgttg atctcacata agccgttggc tcactgcggt
     3301 attggaagat gtttttatgt ggttgtaagt tttcatccat catgaagttg gcattcaata
     3361 aagaagaaat gatttctgac taca
//
LOCUS       NM_001108664            5145 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus Myb/SANT DNA binding domain containing 3
            (Msantd3), transcript variant 2, mRNA.
ACCESSION   NM_001108664 XM_001055826 XM_342834
VERSION     NM_001108664.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5145)
  AUTHORS   Oleskevich,S., Leck,K.J., Matthaei,K. and Hendry,I.A.
  TITLE     Enhanced serotonin response in the hippocampus of Galphaz protein
            knock-out mice
  JOURNAL   Neuroreport 16 (9), 921-925 (2005)
   PUBMED   15931062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001108664.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643285.19280.1, CB585133.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN12840111, SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000005.1  67661616-67661644
            30-480              JAXUCZ010000005.1  67673780-67674230
            481-5145            JAXUCZ010000005.1  67683307-67687971
FEATURES             Location/Qualifiers
     source          1..5145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5145
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT DNA binding domain containing 3"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
     exon            1..29
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="upstream in-frame stop codon"
     exon            30..480
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..890
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain containing 3"
                     /codon_start=1
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 3"
                     /protein_id="NP_001102134.1"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
                     /translation="MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIAL
                     KQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSGSPLLS
                     THVLDKEKIGSMLPEQLYFLQSPPEEEPEYHQDAAAQESFAVSNRELCDDEKEFVHFP
                     VCEGTSQPEPSCSAVRITANKNYRSKTPQEGALKKMHEEEHHQQMSILQLQLIQMNEV
                     HVAKIQQIERECEMAEEEHRIKMEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP"
     misc_feature    90..323
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     misc_feature    90..323
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     exon            481..5145
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaaaaggg ctcgcgctaa ctcgtgcggg ctagccaacg accaggagaa atagagtgga
       61 aaatgcaaaa caacgaaatc attaaacctg ccaagtactt ctcagagctg gagaagagca
      121 tcttgcttgc cttagtagag aagtacaagt atgtgctgga gtgcaagaaa agcgacgcgc
      181 ggactattgc tctcaagcag cggacctggc aggccttggc ccatgagtac aactcgcagc
      241 ccagcgtgtc gctgcgggac ttcaaacagc tgaagaagtg ttgggagaac atcaaggctc
      301 ggaccaaaaa aattatggcc cacgagagga gggagaaggt gaagcgcagc gggagtccgc
      361 tgctgagcac gcacgtcctg gacaaggaga agatcggcag catgctaccg gagcagctct
      421 acttccttca gagcccgccc gaggaggagc ccgagtacca ccaggacgca gccgcccaag
      481 agtcctttgc tgtttcaaat cgagaactgt gcgacgatga gaaagagttt gtccactttc
      541 ctgtatgtga ggggacctca caacctgaac cttcgtgttc agccgtcaga ataacagcca
      601 ataagaacta caggagcaaa acccctcagg aaggtgcttt aaaaaagatg cacgaggagg
      661 agcaccatca gcagatgtcc atcctgcagc tccagctgat ccagatgaat gaggtgcacg
      721 tggccaaaat ccagcagata gaacgggaat gtgagatggc cgaggaggaa caccggatca
      781 agatggaggt cctcaacaag aagaagatgt actgggagag aaagctacag actttcacca
      841 aggagtggcc cgtctcctca tttaaccgac cctttcccaa ttcaccctga gactggggga
      901 tggctccctg tagttaacct gtattggcaa ggcagtgtgg gatgtggcct gcgtggtcag
      961 tagcccgtga cagacctacg gctaggtgaa ttagagtggt actagtcact tattaagaac
     1021 acattcaggt aaacagctgc accccgtcta cccctaaagt ggccaagaag ctgttacagt
     1081 cttctagaag tcaccactac gcgtgctata attctgaatg taatgttctt aattagaatt
     1141 catagaggaa ccatgtgcga gtgttgtatt ttttttttaa gacatgcaag tgtggtgata
     1201 taggagtgag gctggtggtt ctgacctcat ctgtcagtgg ggttttgttt gttttcagct
     1261 gacagtggcg cttttccaca caggtgtgaa gcccacccat tgtgtggctg taccttggct
     1321 gtttctccac ctttcagtgt actctgagtg tgggcgtttg aagagcccag cctttagaag
     1381 ggtgtttcct aatgtgggtt accaactgcc tttttagact tttccccaca gaggctttcc
     1441 aaccagggct ccagccgtgg cggtttcagt agaagtaggg atgtaacaac tggagggctt
     1501 aatgttcatt taggtatcta catcctgttg gttttttatt aaaaatgtct taaaatttta
     1561 tagttacact gtgtatgttt ttaaaggtgc tgctatccca gcccggatcc ctcccaactt
     1621 tttactgctg agtgaatggt tgtctggact ttttagtctc tcactccctt aggagaggcc
     1681 ccgccctcgc tgtgttcatg ctgtatgctg gtgttgacca ccgatcaggg ttagggtgac
     1741 caacatgttt ggaaacgtgg atggataaat gggtgttttg atggagctgt gatgtttctg
     1801 ctgtaacctg atgctttaaa aaaaattttt tttgttttta agagttggga cagtagtagc
     1861 tggaggcggc agggggaccc ttaagagcca gtgttctaag tgtggctctg gctaactccc
     1921 taaaacctca agctggtgct tcctgtccgc agaatgaggg agttgaggag acatttggag
     1981 cctgtttcag ctccttagcc acgttgcggc ttgtgcgact ctctgcatgc actctgactt
     2041 catggcagcc cggagggcat gagtctacac agagttgtct ctagaaatgg ccaagctttg
     2101 gaatttttcg tcccgggcct gttaggtttt gtatggttca caccgactca cagtttgtgc
     2161 actgcatata atgtaagcag atatcaattt tgtacattga atctatttta aatatcttag
     2221 aggaattagt ccgttatttt agatatatcc tgcagtgaga gactagaagt aggatccttc
     2281 catgaggatt tctgtcgttc atttttatca gatgaagcct tcagagagtg aatggtttga
     2341 aagtcacgtt cgatggtacg cagaaggtag gactccactc cctgtgtcct gcctccggat
     2401 agacagggat ggacagcaca aatctaggtg cagagggctg cctttgcttc acgtactgat
     2461 ctaaacatcc tcttaatatc acatccagag taaggcatga ggtctgttct cacaagctcc
     2521 cagattaggc ctgatctgat gctctgctca acacatctct gaatgacaag gacttaaagg
     2581 gaccttagga agttttccat ctcttacata catagatgtg gtggttacga ttttctaaaa
     2641 attcatgact taaactcaca aacagccaca tagaataaca aaaattgcaa cgcattttaa
     2701 ttggactata aaagcattga actaattcct gtctgaacaa atacaggata attaagccag
     2761 agcataaaac cccttgctgt actgctaatg gtatttatga gtttacaata gtagcttgcg
     2821 atatttggct atgtgttagg aataatattt tataaataat tagtcccact gggtctcact
     2881 tccagagggt tctgagtcag ttgacttggg gcggggctgg ctgttgggta tttttggaag
     2941 ctttctaggt gattaggatg cagagttgag attgagagcc actttgtacg gcttacgaat
     3001 gtatttcagt tgcttcttaa ttccacaaag ccatggagaa ggaaggaatt gatgttcgga
     3061 gaagagccca cctggcacca ggcctgtagc cagtaaatag caaagaagaa cttcgggctg
     3121 ggtctcttgg ttccgagatg cacagcccca cctgctgtct ttaccctttc ttttgaagcc
     3181 gagccaagga tgcttgattc tgaggctcga atgacgttac acagttgctt gctgaagcag
     3241 cttcattcat gaacagacag cacatcccag ttcattttgc ttttgagctt tttatttcct
     3301 gaggtagaaa agcaataacc atttcttgac aggaatcgtg ggccagatac acataaaaaa
     3361 atattaagac gtggttctac atcgtgggca ttgcccggga gggagggaag aatggaggga
     3421 gggagggctg gttcgcagct ggctgtagac tcagccggtg cacatcttca aatgctctct
     3481 cagttgaggg cagggagcta agaaaatgga gagcggaatc gtagaagcgt ggtatttgag
     3541 ttgagtctgt ggggctgaca ttttggcagg tagggaaagc agagaacatc accagatgac
     3601 acacaaatgg gagagagaag agtgagctag aggggagttt tcaaatctga tcagaaccgt
     3661 gcaccaggag ggaagttaga agctggaatg gaggggagag gagactgcag ttgggatgac
     3721 aggaaggagg gcttggcttt ggtagccggg atgacaggat ccagaggagg tcgtggaaag
     3781 gagaccaggg tcctgagcga gtggatggtg attgtttttg ttagagagga gtggaaggtg
     3841 ttcacagcta gacttgtgag agaacaatac tgataataac cccgaaatga ggggacgata
     3901 caaatgtcct ctaggatatt tgatgtccta gatgtgccta ggcacagaca ctggtatttg
     3961 ctcccaattc tttgtctacc tcatctctgc agcgacttcc tccttgtcac ctgctgttgt
     4021 tccttctgcc tgttcacttg aactggccct actcagtcct cggtcacctg actatttggt
     4081 acttcctctg tctccaatcc ctccattgtt attaggggca cctcattcag tatcgtctat
     4141 gtcgggttgc actaagatgg ccagaggacg ttgctctttg ttgtttgttt ttgatttttg
     4201 tttttgtctt cgtttttggt cccaagttga ataacaaatc cgtggctgga aaagattggt
     4261 gacttccatg tttgcatatc acagcccttt aaaaaaaatc aaatatggaa ccctacccaa
     4321 tgggtccatg ctttaggaat gtttcaaggg agatgccagg acaatcttta gatgcatttt
     4381 cttttgtttc gcttcagggg gcagagatgg catggtagga gaatgcattg gagttgtcaa
     4441 cagtctctgc cgtgtcaggt caattacatc agcacttggt ctagaccaga ggaaaggaat
     4501 gattgtgcct cctgggaatg tcacaaggac ctgataatta tatttggcaa agccatgagg
     4561 agtggctcgt aatgtcatta ctaagaatta ccctttcagt agcatttctg gacgcctgag
     4621 ctttgcacag ggatggtact tcatttctgt gccttccttc ctgctgggcc tcttcccagg
     4681 tggtccccct actccccctg cccttgctgg ctggctgtat tctccctcca acccaatccc
     4741 cacctcccaa gcccaccttc tgccctcaca gtcgctttca ctgtccagtg gtagaggtga
     4801 aagctacatg ggatgctctt cctgcggatg cccagagggc agctccctca gctcctgcgg
     4861 cagcccctgg acagagctga tttatttcca tgctgcagtc gctacctttg tctacctttg
     4921 tgctcgtggg actcaaagag tcgtgggaaa ggtgaccagg aacctgtgac agcaaccagt
     4981 tctttcccga ctgtgccata tattatgctc ttccacacag tttactaatc tctgcctcag
     5041 tttctccatc tgtaagtgat gtaatactta tctacctccc ttggatgttg tgaagattag
     5101 tatgtgttgg taaagcactt ctgaaataaa gaatgatacc aagca
//
LOCUS       NM_001134702            3150 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus Meis homeobox 1 (Meis1), transcript variant 1,
            mRNA.
ACCESSION   NM_001134702 XM_001054791 XM_001054850 XM_001054906 XM_001054960
            XM_001055028 XM_001070142 XM_001070196 XM_001070244 XM_001070286
            XM_001070326
VERSION     NM_001134702.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Yao,M.Z., Ge,X.Y., Liu,T., Huang,N., Liu,H., Chen,Y., Zhang,Z. and
            Hu,C.P.
  TITLE     MEIS1 regulated proliferation and migration of pulmonary artery
            smooth muscle cells in hypoxia-induced pulmonary hypertension
  JOURNAL   Life Sci 255, 117822 (2020)
   PUBMED   32450174
  REMARK    GeneRIF: MEIS1 regulated the proliferation and migration of
            pulmonary artery smooth muscle cells during hypoxia-induced
            pulmonary hypertension
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Zhang,Y., Si,Y. and Ma,N.
  TITLE     Meis1 promotes poly (rC)-binding protein 2 expression and inhibits
            angiotensin II-induced cardiomyocyte hypertrophy
  JOURNAL   IUBMB Life 68 (1), 13-22 (2016)
   PUBMED   26597775
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Pandey,R., Yang,Y., Jackson,L. and Ahmed,R.P.
  TITLE     MicroRNAs regulating meis1 expression and inducing cardiomyocyte
            proliferation
  JOURNAL   Cardiovasc Regen Med 3 (2016)
   PUBMED   28111633
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Jolma,A., Yin,Y., Nitta,K.R., Dave,K., Popov,A., Taipale,M.,
            Enge,M., Kivioja,T., Morgunova,E. and Taipale,J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Spieler,D., Kaffe,M., Knauf,F., Bessa,J., Tena,J.J., Giesert,F.,
            Schormair,B., Tilch,E., Lee,H., Horsch,M., Czamara,D., Karbalai,N.,
            von Toerne,C., Waldenberger,M., Gieger,C., Lichtner,P.,
            Claussnitzer,M., Naumann,R., Muller-Myhsok,B., Torres,M.,
            Garrett,L., Rozman,J., Klingenspor,M., Gailus-Durner,V., Fuchs,H.,
            Hrabe de Angelis,M., Beckers,J., Holter,S.M., Meitinger,T.,
            Hauck,S.M., Laumen,H., Wurst,W., Casares,F., Gomez-Skarmeta,J.L.
            and Winkelmann,J.
  TITLE     Restless legs syndrome-associated intronic common variant in Meis1
            alters enhancer function in the developing telencephalon
  JOURNAL   Genome Res 24 (4), 592-603 (2014)
   PUBMED   24642863
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   7  (bases 1 to 3150)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   8  (bases 1 to 3150)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 3150)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   10 (bases 1 to 3150)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001134702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161984.1, SRR26643291.36107.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               JAXUCZ010000014.1  97495016-97495753   c
            739-965             JAXUCZ010000014.1  97492951-97493177   c
            966-1107            JAXUCZ010000014.1  97491002-97491143   c
            1108-1158           JAXUCZ010000014.1  97490403-97490453   c
            1159-1209           JAXUCZ010000014.1  97489567-97489617   c
            1210-1356           JAXUCZ010000014.1  97487995-97488141   c
            1357-1468           JAXUCZ010000014.1  97465280-97465391   c
            1469-1614           JAXUCZ010000014.1  97417611-97417756   c
            1615-1691           JAXUCZ010000014.1  97381432-97381508   c
            1692-1750           JAXUCZ010000014.1  97361892-97361950   c
            1751-1840           JAXUCZ010000014.1  97360731-97360820   c
            1841-1935           JAXUCZ010000014.1  97360339-97360433   c
            1936-3150           JAXUCZ010000014.1  97356949-97358163   c
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..3150
                     /gene="Meis1"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
     exon            1..738
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    388..390
                     /gene="Meis1"
                     /note="upstream in-frame stop codon"
     CDS             727..1899
                     /gene="Meis1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein Meis1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog"
                     /codon_start=1
                     /product="homeobox protein Meis1 isoform 1"
                     /protein_id="NP_001128174.1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRAANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            739..965
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1107
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1158
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1209
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1356
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1468
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1614
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1691
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1750
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1840
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1935
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..3150
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctggtcg gaatccacct ctccgcctgt gcaacacaca ctttacacac gcacggcgac
       61 tgcaagcggg cagcatcgat cgtggctcct ttaagacaaa ctcagacaga cattttttta
      121 accctcctct ctaatctccc ttcagtgcag cagttgcaaa gagggagaga gaaagagaaa
      181 gagagcgaga gaagagagaa actgattggg aattaggact gattcaagga aagcgggcgc
      241 tagggctttg tgcatttgaa tattaacatt tgaggtgttc tgaccagaag aagacagaac
      301 ggatgatcat tcattcacca cgttgacaac ctcgcctgtg attgacagct ggagtggcag
      361 aaagccatga gatttggtag ttggttctga ggggcgctct tttttttctt tttcttttct
      421 tttctttctt tttttttaac tgattttttt gggggggaag agaagatctg cttttttttc
      481 cctcccactg ctgtcttggt ggaaccagag cgcttttatg ctcagcgacg cgggcgcctt
      541 gcttcaggtc cggtagaccg aagatctggg accagtaatt cacactgctg gagacgcaaa
      601 gggatttttt tgttactgtt gtgctttatt tttttttccg agggagtttg catatttgtt
      661 tcttttcaca ctggccttaa agaggatata ttagaagttg aagaaggaag ggaggcagag
      721 aggccgatgg cgcaaaggta cgacgatcta ccccattatg ggggcatgga tggagtaggc
      781 atcccctcca cgatgtatgg ggacccgcat gcagccaggt ctatgcagcc ggtccaccac
      841 ctgaaccacg ggcctcctct gcactctcat cagtacccgc acacagctca taccaacgcc
      901 atggccccca gcatgggctc ctcagtcaat gacgctttaa agagagataa agatgccatt
      961 tatggacacc ccctcttccc tctcttagca ctgatttttg agaaatgtga attagctact
     1021 tgtacccccc gcgagccggg ggtggcgggc ggggacgtct gctcgtcaga gtcattcaat
     1081 gaagatatag cggtgttcgc caaacagatt cgtgcagaaa aacctctatt ctcttctaat
     1141 ccagaactgg ataacttgat gatccaagcc atacaagtat taaggtttca tctgttggaa
     1201 ttagagaagg tacacgaatt atgtgacaat ttctgccacc ggtatattag ctgtttgaaa
     1261 gggaaaatgc ctatcgattt ggtgatagat gatagagaag gcggatcaaa atcagacagt
     1321 gaagatgtaa caagagcagc aaatctaact gaccagccct cttggaatag agaccatgat
     1381 gacacggcat ccactcgttc aggaggaacc ccgggccctt ccagcggtgg ccacacttca
     1441 cacagtgggg ataacagcag tgagcaaggt gatggcttgg acaacagtgt agcttccccc
     1501 agcacaggtg acgatgatga ccctgataag gacaaaaagc gtcacaaaaa gcgtggcatc
     1561 tttcccaaag tagccaccaa tatcatgagg gcgtggctgt tccagcatct aacacaccct
     1621 tacccttctg aagagcagaa aaagcagttg gcacaagata cgggactcac catccttcaa
     1681 gtgaacaatt ggtttattaa tgcgcggaga agaatagtgc agcccatgat agatcagtcc
     1741 aaccgagcag tcagccaagg gacaccttat aaccccgatg gacagccaat gggaggtttt
     1801 gtaatggacg gtcagcagca catgggcatc agagcgccag gacctatgag tggaatgggc
     1861 atgaatatgg gcatggaggg gcagtggcac tacatgtaac gttcatctag ttaaccaatc
     1921 gaaagccagg gggaaggctg caaagtatgc caggggagta tgtagcccgg ggtggtccaa
     1981 tgggtgtgag tatgggacag ccgagttata cccaagccca gatgcccccc catcctgctc
     2041 agctgcgtca tgggcccccc atgcatacgt acattcctgg acatcctcac caccccgcag
     2101 tgatgatgca tggaggacag ccccaccctg gaatgccaat gtcagcgtca agcccctcgg
     2161 ttcttaatac aggagacccg acaatgagtg gacaagtcat gaacattcac gctcagtagc
     2221 ttaagggaat atgcattgtc tgcaatggtg actgatctcg aatcatgtct ttttctgcaa
     2281 tgactatgga gttccattct tgacatctac tttggaccaa ggagcatccc taattcttca
     2341 tagggactct taaaaatgca ggaaaaccaa ccgaagtcaa tttgggggac atgcaaaaat
     2401 aactatataa gacattaaaa gaacaaagag tgaaatattg taaatgctat tatactgtta
     2461 tccatattac gttgtttctt atagattttt taaaaaaaat gtgaaatttt tccacactat
     2521 gtgtgttgtt tccatagctc ttcacttcct ccagaagcct ccttacatta aaaagcctta
     2581 cagtcatcct gcaagggaca ggaaggtctg atttgcagga tttttagagc attaaaataa
     2641 ctatcaggca gaagaatctt tcttctcgcc taggatttca gccatgtgcg cgctctctct
     2701 ctctctcctc tctctctctt ctcctctctc tccctctctc tagcctgggg cttgaatttg
     2761 catgtctaat tcatttactc accatatttg aattggcctg aacagatgta aatcgggaag
     2821 gatgggaaaa actgcagtca cccaacaatg attaatcagc tgttgcaggc agtgtcttaa
     2881 ggagactggt agaaggagcc atggaaaccc aaaggccgtg tgtttagaag cctaactgtc
     2941 acgtcaagcg tcatcgtccc catgcgacaa caaccatcac cttatacatc acttcctgtt
     3001 ttatgcagct caaaaaaaca tagactgaag atttattttt aatatgttga ctttgtttct
     3061 cagcaaagca ttggtcatgt gtgtattttt ccatagtccc accttggagc atttatgtag
     3121 acattgtaaa taaattttgt gcaaaaagga
//
LOCUS       NM_001108667            5769 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 2, mRNA.
ACCESSION   NM_001108667 XM_001057514 XM_342838
VERSION     NM_001108667.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5769)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5769)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5769)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5769)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5769)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5769)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5769)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5769)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5769)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5769)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001108667.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2284575.1,
                                           SRR26360172.159457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000005.1  73135386-73135393
            9-211               JAXUCZ010000005.1  73142997-73143199
            212-271             JAXUCZ010000005.1  73151592-73151651
            272-475             JAXUCZ010000005.1  73152711-73152914
            476-753             JAXUCZ010000005.1  73158194-73158471
            754-886             JAXUCZ010000005.1  73160426-73160558
            887-1016            JAXUCZ010000005.1  73165478-73165607
            1017-1150           JAXUCZ010000005.1  73169494-73169627
            1151-1278           JAXUCZ010000005.1  73170920-73171047
            1279-5769           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5769
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..8
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            9..211
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1492
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 2;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001102137.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    107..940
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    107..940
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    971..>1087
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    971..>1087
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            212..271
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            272..475
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            476..753
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            754..886
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1016
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1150
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1278
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..5769
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttagaa gtacctctgt tgacaggaaa caagattctg tttcataaag aagatgaaaa
       61 caactgggtt cctgttaaca aacacccaag agaccagcat agaccaatga gcagagtcaa
      121 taagaacgtg gtcttggccc ttctaacact gatgagctgt gccttcctgc tgtttcagct
      181 gtactactac aagcactact tgtcagcacg gaatggaacg ggttcatcaa aatccaaagg
      241 aaatcgagtt ggatttgata gcacacaatg gcgtgcagtt aagaaattta ttatgctgac
      301 atccagccaa aatgtgccgg tgttccttat tgacccttgg attctggaat caattaataa
      361 aaatttcgaa caagtgaaaa atgcctctca aggctcggcc tcagaatgca gatttttctg
      421 tgttccgaga gacttcactg cgttcgcgct gcagtatcac ctgtggaaga atgaggatgg
      481 atggtttcag atggctgaga acatgggatt ccagtgcctg aagattgaaa gcaaagatcc
      541 tcggctggat ggaatagact cgctttccgg aactgagatc cctctgcact atgtctgtaa
      601 gctggccact cacgccatcc acttggtcgt ctttcacgag aggagtggca actacctctg
      661 gcatggtcac ctacgactca aagggcacat ggataggaag tttgttcctt ttcgaaggct
      721 acaatttggt cgttatcctg gagcctttga caggccggag ttacagcagg ttactgttga
      781 tggactcgac atgcttattc caaaagaccc agggcgcttt ctagaagaag tacctcactc
      841 cagatttatc gagtgcaggt ataaagaagc ccgggcattc cttcagcagt acgtcgatga
      901 caacactgtg gatgccatgg cctttcggaa gagggcaaag gagttactgc aactagcggc
      961 caagacgctg aaggcgctgg gagtgccctt ctggctgagc agtgggacgt gtctaggatg
     1021 gtatcggcaa tgcagtatca ttccttatag caaagatgtc gacctaggaa ttttcattca
     1081 agattacaaa cctgatattg ttttggcatt tcaggatgca ggacttccac tcaaacacaa
     1141 gtttgggaag gtggaggaca gcttggaact ctccttccag ggacaagctg atgtaaaact
     1201 tgatattttt ttcttctatg aagagactga ccatatgtgg aatggaggca cgcaggccag
     1261 aacaggaaag aagtttaagt atctgttccc caagtttaca ctgtgctgga cggagtttgt
     1321 agacataaaa gtccatgttc cctgtgaaac agttgactac attgaagcca actatggcaa
     1381 ggcctggaag atccctgtca agacctggga ctggaagagc tcacccccga atgtgcagcc
     1441 caatggggtc tggcctattt cggagtggga tgaagttatc cagttgtact gagaacactg
     1501 agctcatgtg ggacgtttcc cagaaagaag gtaggcagct gttgaaagca ctatgttttc
     1561 tgcctgatgt gagagccaaa gaggagaaat gacgagttgg aagacagaaa aggttttctg
     1621 actcatgggc catctaatca gttctgccac tcagcattta ctgaggagtt tatacaccag
     1681 gtgaagtact aggatctggt gaacaggcag agaggaatga gaggccagct tctctcttgc
     1741 cctgttggta agcactacaa ttttatgtta agggaaacta acccactctc tgaagaggtg
     1801 tacagtagaa tgtattccat aatgattttt aaaatgttaa ttaatgttta aaccggaaag
     1861 tgagctcatc agacaaagct aacaaaggat gtgttagttg agagtagttc atttctgcct
     1921 gccctcggga tttaagctgc tgtgttagtg ttaaggttgt gggatatgag ttaatattcc
     1981 agtgagtgat tagactttgt ctcacagaga aaagacagtg gccaactcat tttacaagca
     2041 gtgtgataca cagttgactt caagcactgg gcattctata agggaggatg agagccgata
     2101 gcagctcttg tcaagacgta cactgttttc atctttgaga tgaacatgga tgcttagatg
     2161 gtgcttgaat ccctgacatc ataaggatat tttcactgac ctgcagtagt acttcctgat
     2221 aaatcattca gtcgtgctat ccaaaagttg tgacatctca aagcttccgt tccttatttc
     2281 attcttagtc actcttaaac tcaaaaatgg aagttactca tgaatatttt tatattttat
     2341 gaatgtataa cttttctgcc tttaatttta atattgacac taagtaataa tagacatacc
     2401 tcttaatttt ttaaaaatac cctttattta tttatcaacc atagttccat gtgtttaatt
     2461 tatggcctac acactaattt atttagcaca agatatgcct gttcttctat ccaatattac
     2521 ttcacggttc caaaatgaag ggttaacgtg aacctggcca ttactccttt tcccagatta
     2581 ctgtctttaa agcctgtgtc catctctaga ttttcattct gctgagtgta atagggcaag
     2641 ggcttcctac ccacaagtac tgcacaagtg ggacccttga cctacactcc tgagtccatt
     2701 gtagtggctg cacataagcc atgcagtctc agagagagat gacacagtga gtgcctgcct
     2761 gccttgcctg ggaggggagg gtccactccc tgctgcttag ggatgtgctt catggcaacc
     2821 tggcagattt cccttggcac gtgtagttac tacagcagaa accaggatag atgagagaat
     2881 gggctggcag aaagaaaaga aaaaagaaag aaaaagaaaa acttggagga agtaacttga
     2941 agccacctat ttccaaattt aaacttcaac atgaaaactg tctttgttgg atgatatgca
     3001 gcagtctcca tgcagcctcc aagtaggaat attgtctctc cataagcatc atctaatcag
     3061 agtgttacag ttattagcac acatgtaccc aaatgacaaa tcataatcag ctctttccta
     3121 gaaaataagt ccatagaata cgtacccaag ttgtagatac ccaaccctac atatttttct
     3181 gtgtgcgcat gcgtgtgcac gcacacaccc ccactcgcac acaccagata atagtgtttt
     3241 tgaggacaaa cccaccctac ctggagagga tcatttactt gtactcaata tcaagaagta
     3301 tgtttatatc gtgttccttg agagctccca ccttctgcca ggagatctta cccacccctg
     3361 tttaagtttc ttctctcata cctgtcgttg gagtgcaagg tctgccagtg tccataatac
     3421 aagctcttgg tcctgggcac agaggttctg tagtcttccc ttcatagagg atgggtacct
     3481 gttttccctc tggtttggct ttaggtttta ggttccgccc accgtggaga aattttccca
     3541 gaatttgcag gtgaggttta cctctaaaaa tgactccatg attcagtcat actgaagtca
     3601 gtgcttctta actcttgaac tctgctgagt gtcccgagat cttgggtcag gtctgcccac
     3661 cacctgaacc ttttcagatc acttctcttc cctccctgaa tatgctaact gttattctcc
     3721 taatatgagt gctttctggt cccatttgcc tggactgctt gaagatacct ttacattaac
     3781 tcattggtag ttctgctgcc gaggatcttt cagagggacc ctgagaagca gatgctttct
     3841 cggtttacga cagccatcta cttccctaag cgtggaggac ttgccccgct cttggttaca
     3901 gttactgaca ttggccactg agatgaaata atagtaacta aaactggcct ccctgagagt
     3961 acctgagatc cgttcttagt gtggcctcca tgacactcca gtgcttggtg agtcctccag
     4021 tgcctcagtg cctgccattc cccacggaag gcctgaggcg acagaaaatg ctgaggaggg
     4081 atgtttcctc ttgtccagaa ttctcaggct accgtctcac ctttgtctgg ggagggttca
     4141 ggaggtgggc caagggaggg gaagccttat ctacaaaaaa tagaacagtt tatgtctgaa
     4201 gacatcacca gaagtcagtt tctgactctt gaaatgttta aaggatttaa tgatgcatac
     4261 agtgcttcca ttcaggccca gcgttaagta agtactcgcc atttcctagt tctcggttcc
     4321 tttgtaacgt ggaaggctgc acgacagagt tgcttagaac taaaattggg gcactgctga
     4381 gatggcttag caggcaaaag cccttgtcac caaaagtgac atgagtttga ttcccaggac
     4441 ccatgtaatg gaaggaaaga atctcaaatt gcttgtcatc caatacacag actctgatgt
     4501 gcttggagct cctctctagc atgagaggac accacacaca cacacacaca cacacacaca
     4561 cacacacaca cacacacaca cacacacaca cactaagtaa atataatgga aagtttttat
     4621 tttatctaag cattacaggt cgaattatgt gatttttgag tcattgccat attccctcca
     4681 cctgaaacag agctggttct cacttagttg accaagtggt tgtcttctaa tcctatccta
     4741 ttgtactata ccctttaagc acagtcagat tgctcttaag ttttgtgcct tgattttcaa
     4801 tagtccagct ttgggcagct aacatcacta tatataatga tttggagaac caaagatttt
     4861 ggaatgctta gttttattta cctgcctagt ctgtatagaa atgtgggcta gttagtctaa
     4921 ttgcccagca tgtgtgaggt ctggattcag tacaaagcac cagaagtctg agacagaaga
     4981 cttagcacat gctgaaggcc agcttgggct acctagtgag taccagccta tcctgggcta
     5041 cagtgtaaga ccctatattg attgaggaca caggagggaa gagagaaaca gagacagaat
     5101 gagaatatac tcctgtcagc catctgccca tagatgtatg ttttaatcta agcgaggcaa
     5161 aatcaggata tatagtgtgg atttttaaat agttaattgt agacaattaa cagccaattc
     5221 gatattgatg ctttttgtat aggaccaata ggcaagtgta atgtgttgag aaacgtattt
     5281 ccaaacactc agaacaccta ggctaaagcc tgctcctgta actcctggac ctaacgtaga
     5341 aggatcgaag aatctctgtg agggagggcc catgtagtga cgcagacttc cgtctactta
     5401 tgagtaactt tcgcggaagg gaaagctttg tcatataaag tattctgtca agcgctttaa
     5461 gaatgataag cctgtacaaa cttatgacaa tgtgttctaa gcatgggaac cagttcatga
     5521 gtttgttaaa tgtagttctg tcaacatggg acatatgacg atgacatgtg tattgtatgt
     5581 gaactttcta gacaaagtta tgttttaaac aagataaaac tggtatatgc ttaccaggtt
     5641 aagatttggt tttgtcctca ggtatagttt atggtactac tgaaatagtt ttaatgttat
     5701 tactctgatc tgaatttgta atatatagtc tactttggga tgattaataa aaatttttaa
     5761 tctcttgtg
//
LOCUS       NM_001437014            5662 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 11, mRNA.
ACCESSION   NM_001437014 XM_039110248
VERSION     NM_001437014.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5662)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5662)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5662)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5662)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5662)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5662)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5662)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5662)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5662)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5662)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_039110248.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2233762.1,
                                           SRR26643297.18997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  73135386-73135548
            164-366             JAXUCZ010000005.1  73142997-73143199
            367-426             JAXUCZ010000005.1  73151592-73151651
            427-630             JAXUCZ010000005.1  73152711-73152914
            631-908             JAXUCZ010000005.1  73158194-73158471
            909-1041            JAXUCZ010000005.1  73160426-73160558
            1042-1171           JAXUCZ010000005.1  73165478-73165607
            1172-5662           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5662
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..163
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    70..72
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            164..366
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1215
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform c is encoded by transcript variant 11;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform c"
                     /protein_id="NP_001423943.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGICSPSLHCAGRSL"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     exon            367..426
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            427..630
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            631..908
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1041
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1171
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..5662
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg cagaagtacc tctgttgaca
      181 ggaaacaaga ttctgtttca taaagaagat gaaaacaact gggttcctgt taacaaacac
      241 ccaagagacc agcatagacc aatgagcaga gtcaataaga acgtggtctt ggcccttcta
      301 acactgatga gctgtgcctt cctgctgttt cagctgtact actacaagca ctacttgtca
      361 gcacggaatg gaacgggttc atcaaaatcc aaaggaaatc gagttggatt tgatagcaca
      421 caatggcgtg cagttaagaa atttattatg ctgacatcca gccaaaatgt gccggtgttc
      481 cttattgacc cttggattct ggaatcaatt aataaaaatt tcgaacaagt gaaaaatgcc
      541 tctcaaggct cggcctcaga atgcagattt ttctgtgttc cgagagactt cactgcgttc
      601 gcgctgcagt atcacctgtg gaagaatgag gatggatggt ttcagatggc tgagaacatg
      661 ggattccagt gcctgaagat tgaaagcaaa gatcctcggc tggatggaat agactcgctt
      721 tccggaactg agatccctct gcactatgtc tgtaagctgg ccactcacgc catccacttg
      781 gtcgtctttc acgagaggag tggcaactac ctctggcatg gtcacctacg actcaaaggg
      841 cacatggata ggaagtttgt tccttttcga aggctacaat ttggtcgtta tcctggagcc
      901 tttgacaggc cggagttaca gcaggttact gttgatggac tcgacatgct tattccaaaa
      961 gacccagggc gctttctaga agaagtacct cactccagat ttatcgagtg caggtataaa
     1021 gaagcccggg cattccttca gcagtacgtc gatgacaaca ctgtggatgc catggccttt
     1081 cggaagaggg caaaggagtt actgcaacta gcggccaaga cgctgaaggc gctgggagtg
     1141 cccttctggc tgagcagtgg gacgtgtcta ggtatctgtt ccccaagttt acactgtgct
     1201 ggacggagtt tgtagacata aaagtccatg ttccctgtga aacagttgac tacattgaag
     1261 ccaactatgg caaggcctgg aagatccctg tcaagacctg ggactggaag agctcacccc
     1321 cgaatgtgca gcccaatggg gtctggccta tttcggagtg ggatgaagtt atccagttgt
     1381 actgagaaca ctgagctcat gtgggacgtt tcccagaaag aaggtaggca gctgttgaaa
     1441 gcactatgtt ttctgcctga tgtgagagcc aaagaggaga aatgacgagt tggaagacag
     1501 aaaaggtttt ctgactcatg ggccatctaa tcagttctgc cactcagcat ttactgagga
     1561 gtttatacac caggtgaagt actaggatct ggtgaacagg cagagaggaa tgagaggcca
     1621 gcttctctct tgccctgttg gtaagcacta caattttatg ttaagggaaa ctaacccact
     1681 ctctgaagag gtgtacagta gaatgtattc cataatgatt tttaaaatgt taattaatgt
     1741 ttaaaccgga aagtgagctc atcagacaaa gctaacaaag gatgtgttag ttgagagtag
     1801 ttcatttctg cctgccctcg ggatttaagc tgctgtgtta gtgttaaggt tgtgggatat
     1861 gagttaatat tccagtgagt gattagactt tgtctcacag agaaaagaca gtggccaact
     1921 cattttacaa gcagtgtgat acacagttga cttcaagcac tgggcattct ataagggagg
     1981 atgagagccg atagcagctc ttgtcaagac gtacactgtt ttcatctttg agatgaacat
     2041 ggatgcttag atggtgcttg aatccctgac atcataagga tattttcact gacctgcagt
     2101 agtacttcct gataaatcat tcagtcgtgc tatccaaaag ttgtgacatc tcaaagcttc
     2161 cgttccttat ttcattctta gtcactctta aactcaaaaa tggaagttac tcatgaatat
     2221 ttttatattt tatgaatgta taacttttct gcctttaatt ttaatattga cactaagtaa
     2281 taatagacat acctcttaat tttttaaaaa taccctttat ttatttatca accatagttc
     2341 catgtgttta atttatggcc tacacactaa tttatttagc acaagatatg cctgttcttc
     2401 tatccaatat tacttcacgg ttccaaaatg aagggttaac gtgaacctgg ccattactcc
     2461 ttttcccaga ttactgtctt taaagcctgt gtccatctct agattttcat tctgctgagt
     2521 gtaatagggc aagggcttcc tacccacaag tactgcacaa gtgggaccct tgacctacac
     2581 tcctgagtcc attgtagtgg ctgcacataa gccatgcagt ctcagagaga gatgacacag
     2641 tgagtgcctg cctgccttgc ctgggagggg agggtccact ccctgctgct tagggatgtg
     2701 cttcatggca acctggcaga tttcccttgg cacgtgtagt tactacagca gaaaccagga
     2761 tagatgagag aatgggctgg cagaaagaaa agaaaaaaga aagaaaaaga aaaacttgga
     2821 ggaagtaact tgaagccacc tatttccaaa tttaaacttc aacatgaaaa ctgtctttgt
     2881 tggatgatat gcagcagtct ccatgcagcc tccaagtagg aatattgtct ctccataagc
     2941 atcatctaat cagagtgtta cagttattag cacacatgta cccaaatgac aaatcataat
     3001 cagctctttc ctagaaaata agtccataga atacgtaccc aagttgtaga tacccaaccc
     3061 tacatatttt tctgtgtgcg catgcgtgtg cacgcacaca cccccactcg cacacaccag
     3121 ataatagtgt ttttgaggac aaacccaccc tacctggaga ggatcattta cttgtactca
     3181 atatcaagaa gtatgtttat atcgtgttcc ttgagagctc ccaccttctg ccaggagatc
     3241 ttacccaccc ctgtttaagt ttcttctctc atacctgtcg ttggagtgca aggtctgcca
     3301 gtgtccataa tacaagctct tggtcctggg cacagaggtt ctgtagtctt cccttcatag
     3361 aggatgggta cctgttttcc ctctggtttg gctttaggtt ttaggttccg cccaccgtgg
     3421 agaaattttc ccagaatttg caggtgaggt ttacctctaa aaatgactcc atgattcagt
     3481 catactgaag tcagtgcttc ttaactcttg aactctgctg agtgtcccga gatcttgggt
     3541 caggtctgcc caccacctga accttttcag atcacttctc ttccctccct gaatatgcta
     3601 actgttattc tcctaatatg agtgctttct ggtcccattt gcctggactg cttgaagata
     3661 cctttacatt aactcattgg tagttctgct gccgaggatc tttcagaggg accctgagaa
     3721 gcagatgctt tctcggttta cgacagccat ctacttccct aagcgtggag gacttgcccc
     3781 gctcttggtt acagttactg acattggcca ctgagatgaa ataatagtaa ctaaaactgg
     3841 cctccctgag agtacctgag atccgttctt agtgtggcct ccatgacact ccagtgcttg
     3901 gtgagtcctc cagtgcctca gtgcctgcca ttccccacgg aaggcctgag gcgacagaaa
     3961 atgctgagga gggatgtttc ctcttgtcca gaattctcag gctaccgtct cacctttgtc
     4021 tggggagggt tcaggaggtg ggccaaggga ggggaagcct tatctacaaa aaatagaaca
     4081 gtttatgtct gaagacatca ccagaagtca gtttctgact cttgaaatgt ttaaaggatt
     4141 taatgatgca tacagtgctt ccattcaggc ccagcgttaa gtaagtactc gccatttcct
     4201 agttctcggt tcctttgtaa cgtggaaggc tgcacgacag agttgcttag aactaaaatt
     4261 ggggcactgc tgagatggct tagcaggcaa aagcccttgt caccaaaagt gacatgagtt
     4321 tgattcccag gacccatgta atggaaggaa agaatctcaa attgcttgtc atccaataca
     4381 cagactctga tgtgcttgga gctcctctct agcatgagag gacaccacac acacacacac
     4441 acacacacac acacacacac acacacacac acacacacac acacactaag taaatataat
     4501 ggaaagtttt tattttatct aagcattaca ggtcgaatta tgtgattttt gagtcattgc
     4561 catattccct ccacctgaaa cagagctggt tctcacttag ttgaccaagt ggttgtcttc
     4621 taatcctatc ctattgtact atacccttta agcacagtca gattgctctt aagttttgtg
     4681 ccttgatttt caatagtcca gctttgggca gctaacatca ctatatataa tgatttggag
     4741 aaccaaagat tttggaatgc ttagttttat ttacctgcct agtctgtata gaaatgtggg
     4801 ctagttagtc taattgccca gcatgtgtga ggtctggatt cagtacaaag caccagaagt
     4861 ctgagacaga agacttagca catgctgaag gccagcttgg gctacctagt gagtaccagc
     4921 ctatcctggg ctacagtgta agaccctata ttgattgagg acacaggagg gaagagagaa
     4981 acagagacag aatgagaata tactcctgtc agccatctgc ccatagatgt atgttttaat
     5041 ctaagcgagg caaaatcagg atatatagtg tggattttta aatagttaat tgtagacaat
     5101 taacagccaa ttcgatattg atgctttttg tataggacca ataggcaagt gtaatgtgtt
     5161 gagaaacgta tttccaaaca ctcagaacac ctaggctaaa gcctgctcct gtaactcctg
     5221 gacctaacgt agaaggatcg aagaatctct gtgagggagg gcccatgtag tgacgcagac
     5281 ttccgtctac ttatgagtaa ctttcgcgga agggaaagct ttgtcatata aagtattctg
     5341 tcaagcgctt taagaatgat aagcctgtac aaacttatga caatgtgttc taagcatggg
     5401 aaccagttca tgagtttgtt aaatgtagtt ctgtcaacat gggacatatg acgatgacat
     5461 gtgtattgta tgtgaacttt ctagacaaag ttatgtttta aacaagataa aactggtata
     5521 tgcttaccag gttaagattt ggttttgtcc tcaggtatag tttatggtac tactgaaata
     5581 gttttaatgt tattactctg atctgaattt gtaatatata gtctactttg ggatgattaa
     5641 taaaaatttt taatctcttg tg
//
LOCUS       NM_001437013            5507 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 10, mRNA.
ACCESSION   NM_001437013 XM_063287927
VERSION     NM_001437013.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5507)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5507)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5507)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5507)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5507)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5507)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5507)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5507)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5507)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5507)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287927.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.948531.1,
                                           SRR26643299.22863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000005.1  73135386-73135393
            9-211               JAXUCZ010000005.1  73142997-73143199
            212-271             JAXUCZ010000005.1  73151592-73151651
            272-475             JAXUCZ010000005.1  73152711-73152914
            476-753             JAXUCZ010000005.1  73158194-73158471
            754-886             JAXUCZ010000005.1  73160426-73160558
            887-1016            JAXUCZ010000005.1  73165478-73165607
            1017-5507           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5507
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..8
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            9..211
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1060
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform c is encoded by transcript variant 10;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform c"
                     /protein_id="NP_001423942.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGICSPSLHCAGRSL"
     misc_feature    107..940
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    107..940
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     exon            212..271
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            272..475
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            476..753
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            754..886
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1016
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..5507
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttagaa gtacctctgt tgacaggaaa caagattctg tttcataaag aagatgaaaa
       61 caactgggtt cctgttaaca aacacccaag agaccagcat agaccaatga gcagagtcaa
      121 taagaacgtg gtcttggccc ttctaacact gatgagctgt gccttcctgc tgtttcagct
      181 gtactactac aagcactact tgtcagcacg gaatggaacg ggttcatcaa aatccaaagg
      241 aaatcgagtt ggatttgata gcacacaatg gcgtgcagtt aagaaattta ttatgctgac
      301 atccagccaa aatgtgccgg tgttccttat tgacccttgg attctggaat caattaataa
      361 aaatttcgaa caagtgaaaa atgcctctca aggctcggcc tcagaatgca gatttttctg
      421 tgttccgaga gacttcactg cgttcgcgct gcagtatcac ctgtggaaga atgaggatgg
      481 atggtttcag atggctgaga acatgggatt ccagtgcctg aagattgaaa gcaaagatcc
      541 tcggctggat ggaatagact cgctttccgg aactgagatc cctctgcact atgtctgtaa
      601 gctggccact cacgccatcc acttggtcgt ctttcacgag aggagtggca actacctctg
      661 gcatggtcac ctacgactca aagggcacat ggataggaag tttgttcctt ttcgaaggct
      721 acaatttggt cgttatcctg gagcctttga caggccggag ttacagcagg ttactgttga
      781 tggactcgac atgcttattc caaaagaccc agggcgcttt ctagaagaag tacctcactc
      841 cagatttatc gagtgcaggt ataaagaagc ccgggcattc cttcagcagt acgtcgatga
      901 caacactgtg gatgccatgg cctttcggaa gagggcaaag gagttactgc aactagcggc
      961 caagacgctg aaggcgctgg gagtgccctt ctggctgagc agtgggacgt gtctaggtat
     1021 ctgttcccca agtttacact gtgctggacg gagtttgtag acataaaagt ccatgttccc
     1081 tgtgaaacag ttgactacat tgaagccaac tatggcaagg cctggaagat ccctgtcaag
     1141 acctgggact ggaagagctc acccccgaat gtgcagccca atggggtctg gcctatttcg
     1201 gagtgggatg aagttatcca gttgtactga gaacactgag ctcatgtggg acgtttccca
     1261 gaaagaaggt aggcagctgt tgaaagcact atgttttctg cctgatgtga gagccaaaga
     1321 ggagaaatga cgagttggaa gacagaaaag gttttctgac tcatgggcca tctaatcagt
     1381 tctgccactc agcatttact gaggagttta tacaccaggt gaagtactag gatctggtga
     1441 acaggcagag aggaatgaga ggccagcttc tctcttgccc tgttggtaag cactacaatt
     1501 ttatgttaag ggaaactaac ccactctctg aagaggtgta cagtagaatg tattccataa
     1561 tgatttttaa aatgttaatt aatgtttaaa ccggaaagtg agctcatcag acaaagctaa
     1621 caaaggatgt gttagttgag agtagttcat ttctgcctgc cctcgggatt taagctgctg
     1681 tgttagtgtt aaggttgtgg gatatgagtt aatattccag tgagtgatta gactttgtct
     1741 cacagagaaa agacagtggc caactcattt tacaagcagt gtgatacaca gttgacttca
     1801 agcactgggc attctataag ggaggatgag agccgatagc agctcttgtc aagacgtaca
     1861 ctgttttcat ctttgagatg aacatggatg cttagatggt gcttgaatcc ctgacatcat
     1921 aaggatattt tcactgacct gcagtagtac ttcctgataa atcattcagt cgtgctatcc
     1981 aaaagttgtg acatctcaaa gcttccgttc cttatttcat tcttagtcac tcttaaactc
     2041 aaaaatggaa gttactcatg aatattttta tattttatga atgtataact tttctgcctt
     2101 taattttaat attgacacta agtaataata gacatacctc ttaatttttt aaaaataccc
     2161 tttatttatt tatcaaccat agttccatgt gtttaattta tggcctacac actaatttat
     2221 ttagcacaag atatgcctgt tcttctatcc aatattactt cacggttcca aaatgaaggg
     2281 ttaacgtgaa cctggccatt actccttttc ccagattact gtctttaaag cctgtgtcca
     2341 tctctagatt ttcattctgc tgagtgtaat agggcaaggg cttcctaccc acaagtactg
     2401 cacaagtggg acccttgacc tacactcctg agtccattgt agtggctgca cataagccat
     2461 gcagtctcag agagagatga cacagtgagt gcctgcctgc cttgcctggg aggggagggt
     2521 ccactccctg ctgcttaggg atgtgcttca tggcaacctg gcagatttcc cttggcacgt
     2581 gtagttacta cagcagaaac caggatagat gagagaatgg gctggcagaa agaaaagaaa
     2641 aaagaaagaa aaagaaaaac ttggaggaag taacttgaag ccacctattt ccaaatttaa
     2701 acttcaacat gaaaactgtc tttgttggat gatatgcagc agtctccatg cagcctccaa
     2761 gtaggaatat tgtctctcca taagcatcat ctaatcagag tgttacagtt attagcacac
     2821 atgtacccaa atgacaaatc ataatcagct ctttcctaga aaataagtcc atagaatacg
     2881 tacccaagtt gtagataccc aaccctacat atttttctgt gtgcgcatgc gtgtgcacgc
     2941 acacaccccc actcgcacac accagataat agtgtttttg aggacaaacc caccctacct
     3001 ggagaggatc atttacttgt actcaatatc aagaagtatg tttatatcgt gttccttgag
     3061 agctcccacc ttctgccagg agatcttacc cacccctgtt taagtttctt ctctcatacc
     3121 tgtcgttgga gtgcaaggtc tgccagtgtc cataatacaa gctcttggtc ctgggcacag
     3181 aggttctgta gtcttccctt catagaggat gggtacctgt tttccctctg gtttggcttt
     3241 aggttttagg ttccgcccac cgtggagaaa ttttcccaga atttgcaggt gaggtttacc
     3301 tctaaaaatg actccatgat tcagtcatac tgaagtcagt gcttcttaac tcttgaactc
     3361 tgctgagtgt cccgagatct tgggtcaggt ctgcccacca cctgaacctt ttcagatcac
     3421 ttctcttccc tccctgaata tgctaactgt tattctccta atatgagtgc tttctggtcc
     3481 catttgcctg gactgcttga agataccttt acattaactc attggtagtt ctgctgccga
     3541 ggatctttca gagggaccct gagaagcaga tgctttctcg gtttacgaca gccatctact
     3601 tccctaagcg tggaggactt gccccgctct tggttacagt tactgacatt ggccactgag
     3661 atgaaataat agtaactaaa actggcctcc ctgagagtac ctgagatccg ttcttagtgt
     3721 ggcctccatg acactccagt gcttggtgag tcctccagtg cctcagtgcc tgccattccc
     3781 cacggaaggc ctgaggcgac agaaaatgct gaggagggat gtttcctctt gtccagaatt
     3841 ctcaggctac cgtctcacct ttgtctgggg agggttcagg aggtgggcca agggagggga
     3901 agccttatct acaaaaaata gaacagttta tgtctgaaga catcaccaga agtcagtttc
     3961 tgactcttga aatgtttaaa ggatttaatg atgcatacag tgcttccatt caggcccagc
     4021 gttaagtaag tactcgccat ttcctagttc tcggttcctt tgtaacgtgg aaggctgcac
     4081 gacagagttg cttagaacta aaattggggc actgctgaga tggcttagca ggcaaaagcc
     4141 cttgtcacca aaagtgacat gagtttgatt cccaggaccc atgtaatgga aggaaagaat
     4201 ctcaaattgc ttgtcatcca atacacagac tctgatgtgc ttggagctcc tctctagcat
     4261 gagaggacac cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     4321 cacacacaca ctaagtaaat ataatggaaa gtttttattt tatctaagca ttacaggtcg
     4381 aattatgtga tttttgagtc attgccatat tccctccacc tgaaacagag ctggttctca
     4441 cttagttgac caagtggttg tcttctaatc ctatcctatt gtactatacc ctttaagcac
     4501 agtcagattg ctcttaagtt ttgtgccttg attttcaata gtccagcttt gggcagctaa
     4561 catcactata tataatgatt tggagaacca aagattttgg aatgcttagt tttatttacc
     4621 tgcctagtct gtatagaaat gtgggctagt tagtctaatt gcccagcatg tgtgaggtct
     4681 ggattcagta caaagcacca gaagtctgag acagaagact tagcacatgc tgaaggccag
     4741 cttgggctac ctagtgagta ccagcctatc ctgggctaca gtgtaagacc ctatattgat
     4801 tgaggacaca ggagggaaga gagaaacaga gacagaatga gaatatactc ctgtcagcca
     4861 tctgcccata gatgtatgtt ttaatctaag cgaggcaaaa tcaggatata tagtgtggat
     4921 ttttaaatag ttaattgtag acaattaaca gccaattcga tattgatgct ttttgtatag
     4981 gaccaatagg caagtgtaat gtgttgagaa acgtatttcc aaacactcag aacacctagg
     5041 ctaaagcctg ctcctgtaac tcctggacct aacgtagaag gatcgaagaa tctctgtgag
     5101 ggagggccca tgtagtgacg cagacttccg tctacttatg agtaactttc gcggaaggga
     5161 aagctttgtc atataaagta ttctgtcaag cgctttaaga atgataagcc tgtacaaact
     5221 tatgacaatg tgttctaagc atgggaacca gttcatgagt ttgttaaatg tagttctgtc
     5281 aacatgggac atatgacgat gacatgtgta ttgtatgtga actttctaga caaagttatg
     5341 ttttaaacaa gataaaactg gtatatgctt accaggttaa gatttggttt tgtcctcagg
     5401 tatagtttat ggtactactg aaatagtttt aatgttatta ctctgatctg aatttgtaat
     5461 atatagtcta ctttgggatg attaataaaa atttttaatc tcttgtg
//
LOCUS       NM_001437008            6320 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 6, mRNA.
ACCESSION   NM_001437008 XM_063287923
VERSION     NM_001437008.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6320)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6320)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6320)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 6320)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 6320)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 6320)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 6320)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 6320)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 6320)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 6320)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_063287923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.27356.1,
                                           SRR26360194.384153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000005.1  73135386-73135944
            560-762             JAXUCZ010000005.1  73142997-73143199
            763-822             JAXUCZ010000005.1  73151592-73151651
            823-1026            JAXUCZ010000005.1  73152711-73152914
            1027-1304           JAXUCZ010000005.1  73158194-73158471
            1305-1437           JAXUCZ010000005.1  73160426-73160558
            1438-1567           JAXUCZ010000005.1  73165478-73165607
            1568-1701           JAXUCZ010000005.1  73169494-73169627
            1702-1829           JAXUCZ010000005.1  73170920-73171047
            1830-6320           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..6320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6320
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..559
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    529..531
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            560..762
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..2043
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 6;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423937.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    658..1491
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    658..1491
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1522..>1638
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1522..>1638
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            763..822
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1026
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1304
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1437
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1567
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1701
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1829
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..6320
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg caggtacgcg agcttgctgc
      181 cgccacaggg acagatgggt ctcacatgcc catgctgttc gttgatcatc ctgacaccgc
      241 ttcgattttt ggaggttcat ggagacgctt gtagaggccg ggttggaaca gtgatgtttg
      301 agctgggcgg cgagagcgaa ccacgcgagt agaacgatcg gtcgggtgtg aggaccaatt
      361 ccttgccaag gttcctccgc aggggaggaa ctgctgcagc ccgctgctct gagtgcatcc
      421 tccgcggtgg ctggaggcat gaactcactg ggaaaggaag ggagaatggc cacccaggga
      481 gggttccacg aggcgaattt tggtcctgcg cgaaagacaa gttctgtgta gagcagccat
      541 ctgccaccct tcgaagggaa agtacctctg ttgacaggaa acaagattct gtttcataaa
      601 gaagatgaaa acaactgggt tcctgttaac aaacacccaa gagaccagca tagaccaatg
      661 agcagagtca ataagaacgt ggtcttggcc cttctaacac tgatgagctg tgccttcctg
      721 ctgtttcagc tgtactacta caagcactac ttgtcagcac ggaatggaac gggttcatca
      781 aaatccaaag gaaatcgagt tggatttgat agcacacaat ggcgtgcagt taagaaattt
      841 attatgctga catccagcca aaatgtgccg gtgttcctta ttgacccttg gattctggaa
      901 tcaattaata aaaatttcga acaagtgaaa aatgcctctc aaggctcggc ctcagaatgc
      961 agatttttct gtgttccgag agacttcact gcgttcgcgc tgcagtatca cctgtggaag
     1021 aatgaggatg gatggtttca gatggctgag aacatgggat tccagtgcct gaagattgaa
     1081 agcaaagatc ctcggctgga tggaatagac tcgctttccg gaactgagat ccctctgcac
     1141 tatgtctgta agctggccac tcacgccatc cacttggtcg tctttcacga gaggagtggc
     1201 aactacctct ggcatggtca cctacgactc aaagggcaca tggataggaa gtttgttcct
     1261 tttcgaaggc tacaatttgg tcgttatcct ggagcctttg acaggccgga gttacagcag
     1321 gttactgttg atggactcga catgcttatt ccaaaagacc cagggcgctt tctagaagaa
     1381 gtacctcact ccagatttat cgagtgcagg tataaagaag cccgggcatt ccttcagcag
     1441 tacgtcgatg acaacactgt ggatgccatg gcctttcgga agagggcaaa ggagttactg
     1501 caactagcgg ccaagacgct gaaggcgctg ggagtgccct tctggctgag cagtgggacg
     1561 tgtctaggat ggtatcggca atgcagtatc attccttata gcaaagatgt cgacctagga
     1621 attttcattc aagattacaa acctgatatt gttttggcat ttcaggatgc aggacttcca
     1681 ctcaaacaca agtttgggaa ggtggaggac agcttggaac tctccttcca gggacaagct
     1741 gatgtaaaac ttgatatttt tttcttctat gaagagactg accatatgtg gaatggaggc
     1801 acgcaggcca gaacaggaaa gaagtttaag tatctgttcc ccaagtttac actgtgctgg
     1861 acggagtttg tagacataaa agtccatgtt ccctgtgaaa cagttgacta cattgaagcc
     1921 aactatggca aggcctggaa gatccctgtc aagacctggg actggaagag ctcacccccg
     1981 aatgtgcagc ccaatggggt ctggcctatt tcggagtggg atgaagttat ccagttgtac
     2041 tgagaacact gagctcatgt gggacgtttc ccagaaagaa ggtaggcagc tgttgaaagc
     2101 actatgtttt ctgcctgatg tgagagccaa agaggagaaa tgacgagttg gaagacagaa
     2161 aaggttttct gactcatggg ccatctaatc agttctgcca ctcagcattt actgaggagt
     2221 ttatacacca ggtgaagtac taggatctgg tgaacaggca gagaggaatg agaggccagc
     2281 ttctctcttg ccctgttggt aagcactaca attttatgtt aagggaaact aacccactct
     2341 ctgaagaggt gtacagtaga atgtattcca taatgatttt taaaatgtta attaatgttt
     2401 aaaccggaaa gtgagctcat cagacaaagc taacaaagga tgtgttagtt gagagtagtt
     2461 catttctgcc tgccctcggg atttaagctg ctgtgttagt gttaaggttg tgggatatga
     2521 gttaatattc cagtgagtga ttagactttg tctcacagag aaaagacagt ggccaactca
     2581 ttttacaagc agtgtgatac acagttgact tcaagcactg ggcattctat aagggaggat
     2641 gagagccgat agcagctctt gtcaagacgt acactgtttt catctttgag atgaacatgg
     2701 atgcttagat ggtgcttgaa tccctgacat cataaggata ttttcactga cctgcagtag
     2761 tacttcctga taaatcattc agtcgtgcta tccaaaagtt gtgacatctc aaagcttccg
     2821 ttccttattt cattcttagt cactcttaaa ctcaaaaatg gaagttactc atgaatattt
     2881 ttatatttta tgaatgtata acttttctgc ctttaatttt aatattgaca ctaagtaata
     2941 atagacatac ctcttaattt tttaaaaata ccctttattt atttatcaac catagttcca
     3001 tgtgtttaat ttatggccta cacactaatt tatttagcac aagatatgcc tgttcttcta
     3061 tccaatatta cttcacggtt ccaaaatgaa gggttaacgt gaacctggcc attactcctt
     3121 ttcccagatt actgtcttta aagcctgtgt ccatctctag attttcattc tgctgagtgt
     3181 aatagggcaa gggcttccta cccacaagta ctgcacaagt gggacccttg acctacactc
     3241 ctgagtccat tgtagtggct gcacataagc catgcagtct cagagagaga tgacacagtg
     3301 agtgcctgcc tgccttgcct gggaggggag ggtccactcc ctgctgctta gggatgtgct
     3361 tcatggcaac ctggcagatt tcccttggca cgtgtagtta ctacagcaga aaccaggata
     3421 gatgagagaa tgggctggca gaaagaaaag aaaaaagaaa gaaaaagaaa aacttggagg
     3481 aagtaacttg aagccaccta tttccaaatt taaacttcaa catgaaaact gtctttgttg
     3541 gatgatatgc agcagtctcc atgcagcctc caagtaggaa tattgtctct ccataagcat
     3601 catctaatca gagtgttaca gttattagca cacatgtacc caaatgacaa atcataatca
     3661 gctctttcct agaaaataag tccatagaat acgtacccaa gttgtagata cccaacccta
     3721 catatttttc tgtgtgcgca tgcgtgtgca cgcacacacc cccactcgca cacaccagat
     3781 aatagtgttt ttgaggacaa acccacccta cctggagagg atcatttact tgtactcaat
     3841 atcaagaagt atgtttatat cgtgttcctt gagagctccc accttctgcc aggagatctt
     3901 acccacccct gtttaagttt cttctctcat acctgtcgtt ggagtgcaag gtctgccagt
     3961 gtccataata caagctcttg gtcctgggca cagaggttct gtagtcttcc cttcatagag
     4021 gatgggtacc tgttttccct ctggtttggc tttaggtttt aggttccgcc caccgtggag
     4081 aaattttccc agaatttgca ggtgaggttt acctctaaaa atgactccat gattcagtca
     4141 tactgaagtc agtgcttctt aactcttgaa ctctgctgag tgtcccgaga tcttgggtca
     4201 ggtctgccca ccacctgaac cttttcagat cacttctctt ccctccctga atatgctaac
     4261 tgttattctc ctaatatgag tgctttctgg tcccatttgc ctggactgct tgaagatacc
     4321 tttacattaa ctcattggta gttctgctgc cgaggatctt tcagagggac cctgagaagc
     4381 agatgctttc tcggtttacg acagccatct acttccctaa gcgtggagga cttgccccgc
     4441 tcttggttac agttactgac attggccact gagatgaaat aatagtaact aaaactggcc
     4501 tccctgagag tacctgagat ccgttcttag tgtggcctcc atgacactcc agtgcttggt
     4561 gagtcctcca gtgcctcagt gcctgccatt ccccacggaa ggcctgaggc gacagaaaat
     4621 gctgaggagg gatgtttcct cttgtccaga attctcaggc taccgtctca cctttgtctg
     4681 gggagggttc aggaggtggg ccaagggagg ggaagcctta tctacaaaaa atagaacagt
     4741 ttatgtctga agacatcacc agaagtcagt ttctgactct tgaaatgttt aaaggattta
     4801 atgatgcata cagtgcttcc attcaggccc agcgttaagt aagtactcgc catttcctag
     4861 ttctcggttc ctttgtaacg tggaaggctg cacgacagag ttgcttagaa ctaaaattgg
     4921 ggcactgctg agatggctta gcaggcaaaa gcccttgtca ccaaaagtga catgagtttg
     4981 attcccagga cccatgtaat ggaaggaaag aatctcaaat tgcttgtcat ccaatacaca
     5041 gactctgatg tgcttggagc tcctctctag catgagagga caccacacac acacacacac
     5101 acacacacac acacacacac acacacacac acacacacac acactaagta aatataatgg
     5161 aaagttttta ttttatctaa gcattacagg tcgaattatg tgatttttga gtcattgcca
     5221 tattccctcc acctgaaaca gagctggttc tcacttagtt gaccaagtgg ttgtcttcta
     5281 atcctatcct attgtactat accctttaag cacagtcaga ttgctcttaa gttttgtgcc
     5341 ttgattttca atagtccagc tttgggcagc taacatcact atatataatg atttggagaa
     5401 ccaaagattt tggaatgctt agttttattt acctgcctag tctgtataga aatgtgggct
     5461 agttagtcta attgcccagc atgtgtgagg tctggattca gtacaaagca ccagaagtct
     5521 gagacagaag acttagcaca tgctgaaggc cagcttgggc tacctagtga gtaccagcct
     5581 atcctgggct acagtgtaag accctatatt gattgaggac acaggaggga agagagaaac
     5641 agagacagaa tgagaatata ctcctgtcag ccatctgccc atagatgtat gttttaatct
     5701 aagcgaggca aaatcaggat atatagtgtg gatttttaaa tagttaattg tagacaatta
     5761 acagccaatt cgatattgat gctttttgta taggaccaat aggcaagtgt aatgtgttga
     5821 gaaacgtatt tccaaacact cagaacacct aggctaaagc ctgctcctgt aactcctgga
     5881 cctaacgtag aaggatcgaa gaatctctgt gagggagggc ccatgtagtg acgcagactt
     5941 ccgtctactt atgagtaact ttcgcggaag ggaaagcttt gtcatataaa gtattctgtc
     6001 aagcgcttta agaatgataa gcctgtacaa acttatgaca atgtgttcta agcatgggaa
     6061 ccagttcatg agtttgttaa atgtagttct gtcaacatgg gacatatgac gatgacatgt
     6121 gtattgtatg tgaactttct agacaaagtt atgttttaaa caagataaaa ctggtatatg
     6181 cttaccaggt taagatttgg ttttgtcctc aggtatagtt tatggtacta ctgaaatagt
     6241 tttaatgtta ttactctgat ctgaatttgt aatatatagt ctactttggg atgattaata
     6301 aaaattttta atctcttgtg
//
LOCUS       NM_001436969            1219 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 8, mRNA.
ACCESSION   NM_001436969
VERSION     NM_001436969.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.770443.1,
                                           SRR26360194.841120.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840117,
                                           SAMN12840132 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               JAXUCZ010000005.1  65211053-65211292   c
            241-445             JAXUCZ010000005.1  65207932-65208136   c
            446-759             JAXUCZ010000005.1  65204444-65204757   c
            760-880             JAXUCZ010000005.1  65202357-65202477   c
            881-1006            JAXUCZ010000005.1  65198348-65198473   c
            1007-1219           JAXUCZ010000005.1  65197446-65197658   c
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..240
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            241..445
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    272..274
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             281..1183
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform c is encoded by transcript variant 8;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform c"
                     /protein_id="NP_001423898.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGMLMFYRSVTLRHRYKVYKKVKY"
     misc_feature    785..>1081
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    785..>1081
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     exon            446..759
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            760..880
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1006
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggctcca gggcggggag cagcgccaag ttggagaagg gagacccagg aaaggcctag
       61 gtattgcggg tacgtgttct cgcttttgcc gtctggctgt agacgtctcg ggaaaactga
      121 gcggggaaga agggcaagcc actctcagcg gtaggggagc caggcccgcc cggccgagcc
      181 tgcttactgc cgtcctactg ctcacctctt ccagctgacg ggcgcctcag ctattgatcg
      241 atacttgact gaaagggatc catcccactg ataaaaccag atgccttctc ccacttcagc
      301 agacgaagag gatggcctgg agacctgtgt tttaaagact tttgatctgg atttaaaaga
      361 atcaaatatt gttactccaa gcaatagtct caaagcagag ttagatggca gtacaaagaa
      421 gaaatactcg tttgcaaaga aaaaggcctt tgcccttttt gtcaaaacca aacaagttcc
      481 agtgccttct tatgaagtta aggaaagacg gtggcgatgt tgtcagcagc tgtttgcaga
      541 gcagaccagc atccacagac atgtggccac acagcacgct gaagacgtgt accagcagac
      601 tgcttccatt ctcaagcagc tcactgcagc actgaggacc ccacagagtc ttacgcccac
      661 agaccggagg agctccccaa aagactgtct ccctcctagt caggatgtgt ctgcttggct
      721 ccctgatgtg agccacgtta gcccgcaaga gctgaggagt ggccagggca atgaggaagg
      781 agaggtgctc ctgtattact gctactgtga cttggaggac cccgactggg tctgtgcctg
      841 gcaggcagct ctgtgccgtc acctgcacct tacaggcaag attcggatcg cgacagaagg
      901 aatcaatgga accgttggag gaagcaaagt ggccacccga ctctacatgg aagtcatgct
      961 ttcttgccca ttatttaagg attacctgag cgaggatgat tttaagagca gcaaaggagg
     1021 gtctcactgc ttcccggaat tgcgagtcgg tgtgttcgaa gagatcgtgc ccatggggat
     1081 cagccccagt gaggtctcct acaagaaccc cggtatgctt atgttttaca gaagtgttac
     1141 tcttcgtcat agatataaag tgtataagaa agttaaatac tgattagcaa aaactgtaat
     1201 aaaccttctc tttaaaata
//
LOCUS       NM_001437006            6052 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 4, mRNA.
ACCESSION   NM_001437006 XM_006238166
VERSION     NM_001437006.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 6052)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 6052)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 6052)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 6052)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 6052)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 6052)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 6052)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006238166.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18993.1,
                                           SRR26643293.27878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000005.1  73135386-73135393
            9-218               JAXUCZ010000005.1  73140265-73140474
            219-291             JAXUCZ010000005.1  73141847-73141919
            292-494             JAXUCZ010000005.1  73142997-73143199
            495-554             JAXUCZ010000005.1  73151592-73151651
            555-758             JAXUCZ010000005.1  73152711-73152914
            759-1036            JAXUCZ010000005.1  73158194-73158471
            1037-1169           JAXUCZ010000005.1  73160426-73160558
            1170-1299           JAXUCZ010000005.1  73165478-73165607
            1300-1433           JAXUCZ010000005.1  73169494-73169627
            1434-1561           JAXUCZ010000005.1  73170920-73171047
            1562-6052           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6052
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..8
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            9..218
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            219..291
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            292..494
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1775
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 4;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423935.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    390..1223
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    390..1223
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1254..>1370
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1254..>1370
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            495..554
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            555..758
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1036
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1169
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1299
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1433
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1561
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..6052
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttagat tcagattgtg tgtgtggatt gtttcaaagc tccgcacaaa gacttaggac
       61 tttaattaaa atggcagagt gaaaatactt gtactttatt caatctgaag ttaccctgaa
      121 aaaaacatga aaaatggaag atggatctta acacagcttc cccaacgcaa atattgctgt
      181 gaccccaaac tgaaatgttt gagaggtggt tgccacagct gcagaggtga gtgggcaaag
      241 agtatggcaa tagagtcacc gtgggacact ggagtaaaag cgaaataaca gaagtacctc
      301 tgttgacagg aaacaagatt ctgtttcata aagaagatga aaacaactgg gttcctgtta
      361 acaaacaccc aagagaccag catagaccaa tgagcagagt caataagaac gtggtcttgg
      421 cccttctaac actgatgagc tgtgccttcc tgctgtttca gctgtactac tacaagcact
      481 acttgtcagc acggaatgga acgggttcat caaaatccaa aggaaatcga gttggatttg
      541 atagcacaca atggcgtgca gttaagaaat ttattatgct gacatccagc caaaatgtgc
      601 cggtgttcct tattgaccct tggattctgg aatcaattaa taaaaatttc gaacaagtga
      661 aaaatgcctc tcaaggctcg gcctcagaat gcagattttt ctgtgttccg agagacttca
      721 ctgcgttcgc gctgcagtat cacctgtgga agaatgagga tggatggttt cagatggctg
      781 agaacatggg attccagtgc ctgaagattg aaagcaaaga tcctcggctg gatggaatag
      841 actcgctttc cggaactgag atccctctgc actatgtctg taagctggcc actcacgcca
      901 tccacttggt cgtctttcac gagaggagtg gcaactacct ctggcatggt cacctacgac
      961 tcaaagggca catggatagg aagtttgttc cttttcgaag gctacaattt ggtcgttatc
     1021 ctggagcctt tgacaggccg gagttacagc aggttactgt tgatggactc gacatgctta
     1081 ttccaaaaga cccagggcgc tttctagaag aagtacctca ctccagattt atcgagtgca
     1141 ggtataaaga agcccgggca ttccttcagc agtacgtcga tgacaacact gtggatgcca
     1201 tggcctttcg gaagagggca aaggagttac tgcaactagc ggccaagacg ctgaaggcgc
     1261 tgggagtgcc cttctggctg agcagtggga cgtgtctagg atggtatcgg caatgcagta
     1321 tcattcctta tagcaaagat gtcgacctag gaattttcat tcaagattac aaacctgata
     1381 ttgttttggc atttcaggat gcaggacttc cactcaaaca caagtttggg aaggtggagg
     1441 acagcttgga actctccttc cagggacaag ctgatgtaaa acttgatatt tttttcttct
     1501 atgaagagac tgaccatatg tggaatggag gcacgcaggc cagaacagga aagaagttta
     1561 agtatctgtt ccccaagttt acactgtgct ggacggagtt tgtagacata aaagtccatg
     1621 ttccctgtga aacagttgac tacattgaag ccaactatgg caaggcctgg aagatccctg
     1681 tcaagacctg ggactggaag agctcacccc cgaatgtgca gcccaatggg gtctggccta
     1741 tttcggagtg ggatgaagtt atccagttgt actgagaaca ctgagctcat gtgggacgtt
     1801 tcccagaaag aaggtaggca gctgttgaaa gcactatgtt ttctgcctga tgtgagagcc
     1861 aaagaggaga aatgacgagt tggaagacag aaaaggtttt ctgactcatg ggccatctaa
     1921 tcagttctgc cactcagcat ttactgagga gtttatacac caggtgaagt actaggatct
     1981 ggtgaacagg cagagaggaa tgagaggcca gcttctctct tgccctgttg gtaagcacta
     2041 caattttatg ttaagggaaa ctaacccact ctctgaagag gtgtacagta gaatgtattc
     2101 cataatgatt tttaaaatgt taattaatgt ttaaaccgga aagtgagctc atcagacaaa
     2161 gctaacaaag gatgtgttag ttgagagtag ttcatttctg cctgccctcg ggatttaagc
     2221 tgctgtgtta gtgttaaggt tgtgggatat gagttaatat tccagtgagt gattagactt
     2281 tgtctcacag agaaaagaca gtggccaact cattttacaa gcagtgtgat acacagttga
     2341 cttcaagcac tgggcattct ataagggagg atgagagccg atagcagctc ttgtcaagac
     2401 gtacactgtt ttcatctttg agatgaacat ggatgcttag atggtgcttg aatccctgac
     2461 atcataagga tattttcact gacctgcagt agtacttcct gataaatcat tcagtcgtgc
     2521 tatccaaaag ttgtgacatc tcaaagcttc cgttccttat ttcattctta gtcactctta
     2581 aactcaaaaa tggaagttac tcatgaatat ttttatattt tatgaatgta taacttttct
     2641 gcctttaatt ttaatattga cactaagtaa taatagacat acctcttaat tttttaaaaa
     2701 taccctttat ttatttatca accatagttc catgtgttta atttatggcc tacacactaa
     2761 tttatttagc acaagatatg cctgttcttc tatccaatat tacttcacgg ttccaaaatg
     2821 aagggttaac gtgaacctgg ccattactcc ttttcccaga ttactgtctt taaagcctgt
     2881 gtccatctct agattttcat tctgctgagt gtaatagggc aagggcttcc tacccacaag
     2941 tactgcacaa gtgggaccct tgacctacac tcctgagtcc attgtagtgg ctgcacataa
     3001 gccatgcagt ctcagagaga gatgacacag tgagtgcctg cctgccttgc ctgggagggg
     3061 agggtccact ccctgctgct tagggatgtg cttcatggca acctggcaga tttcccttgg
     3121 cacgtgtagt tactacagca gaaaccagga tagatgagag aatgggctgg cagaaagaaa
     3181 agaaaaaaga aagaaaaaga aaaacttgga ggaagtaact tgaagccacc tatttccaaa
     3241 tttaaacttc aacatgaaaa ctgtctttgt tggatgatat gcagcagtct ccatgcagcc
     3301 tccaagtagg aatattgtct ctccataagc atcatctaat cagagtgtta cagttattag
     3361 cacacatgta cccaaatgac aaatcataat cagctctttc ctagaaaata agtccataga
     3421 atacgtaccc aagttgtaga tacccaaccc tacatatttt tctgtgtgcg catgcgtgtg
     3481 cacgcacaca cccccactcg cacacaccag ataatagtgt ttttgaggac aaacccaccc
     3541 tacctggaga ggatcattta cttgtactca atatcaagaa gtatgtttat atcgtgttcc
     3601 ttgagagctc ccaccttctg ccaggagatc ttacccaccc ctgtttaagt ttcttctctc
     3661 atacctgtcg ttggagtgca aggtctgcca gtgtccataa tacaagctct tggtcctggg
     3721 cacagaggtt ctgtagtctt cccttcatag aggatgggta cctgttttcc ctctggtttg
     3781 gctttaggtt ttaggttccg cccaccgtgg agaaattttc ccagaatttg caggtgaggt
     3841 ttacctctaa aaatgactcc atgattcagt catactgaag tcagtgcttc ttaactcttg
     3901 aactctgctg agtgtcccga gatcttgggt caggtctgcc caccacctga accttttcag
     3961 atcacttctc ttccctccct gaatatgcta actgttattc tcctaatatg agtgctttct
     4021 ggtcccattt gcctggactg cttgaagata cctttacatt aactcattgg tagttctgct
     4081 gccgaggatc tttcagaggg accctgagaa gcagatgctt tctcggttta cgacagccat
     4141 ctacttccct aagcgtggag gacttgcccc gctcttggtt acagttactg acattggcca
     4201 ctgagatgaa ataatagtaa ctaaaactgg cctccctgag agtacctgag atccgttctt
     4261 agtgtggcct ccatgacact ccagtgcttg gtgagtcctc cagtgcctca gtgcctgcca
     4321 ttccccacgg aaggcctgag gcgacagaaa atgctgagga gggatgtttc ctcttgtcca
     4381 gaattctcag gctaccgtct cacctttgtc tggggagggt tcaggaggtg ggccaaggga
     4441 ggggaagcct tatctacaaa aaatagaaca gtttatgtct gaagacatca ccagaagtca
     4501 gtttctgact cttgaaatgt ttaaaggatt taatgatgca tacagtgctt ccattcaggc
     4561 ccagcgttaa gtaagtactc gccatttcct agttctcggt tcctttgtaa cgtggaaggc
     4621 tgcacgacag agttgcttag aactaaaatt ggggcactgc tgagatggct tagcaggcaa
     4681 aagcccttgt caccaaaagt gacatgagtt tgattcccag gacccatgta atggaaggaa
     4741 agaatctcaa attgcttgtc atccaataca cagactctga tgtgcttgga gctcctctct
     4801 agcatgagag gacaccacac acacacacac acacacacac acacacacac acacacacac
     4861 acacacacac acacactaag taaatataat ggaaagtttt tattttatct aagcattaca
     4921 ggtcgaatta tgtgattttt gagtcattgc catattccct ccacctgaaa cagagctggt
     4981 tctcacttag ttgaccaagt ggttgtcttc taatcctatc ctattgtact atacccttta
     5041 agcacagtca gattgctctt aagttttgtg ccttgatttt caatagtcca gctttgggca
     5101 gctaacatca ctatatataa tgatttggag aaccaaagat tttggaatgc ttagttttat
     5161 ttacctgcct agtctgtata gaaatgtggg ctagttagtc taattgccca gcatgtgtga
     5221 ggtctggatt cagtacaaag caccagaagt ctgagacaga agacttagca catgctgaag
     5281 gccagcttgg gctacctagt gagtaccagc ctatcctggg ctacagtgta agaccctata
     5341 ttgattgagg acacaggagg gaagagagaa acagagacag aatgagaata tactcctgtc
     5401 agccatctgc ccatagatgt atgttttaat ctaagcgagg caaaatcagg atatatagtg
     5461 tggattttta aatagttaat tgtagacaat taacagccaa ttcgatattg atgctttttg
     5521 tataggacca ataggcaagt gtaatgtgtt gagaaacgta tttccaaaca ctcagaacac
     5581 ctaggctaaa gcctgctcct gtaactcctg gacctaacgt agaaggatcg aagaatctct
     5641 gtgagggagg gcccatgtag tgacgcagac ttccgtctac ttatgagtaa ctttcgcgga
     5701 agggaaagct ttgtcatata aagtattctg tcaagcgctt taagaatgat aagcctgtac
     5761 aaacttatga caatgtgttc taagcatggg aaccagttca tgagtttgtt aaatgtagtt
     5821 ctgtcaacat gggacatatg acgatgacat gtgtattgta tgtgaacttt ctagacaaag
     5881 ttatgtttta aacaagataa aactggtata tgcttaccag gttaagattt ggttttgtcc
     5941 tcaggtatag tttatggtac tactgaaata gttttaatgt tattactctg atctgaattt
     6001 gtaatatata gtctactttg ggatgattaa taaaaatttt taatctcttg tg
//
LOCUS       NM_001437012            5796 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 9, mRNA.
ACCESSION   NM_001437012 XM_039110247
VERSION     NM_001437012.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5796)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5796)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5796)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5796)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5796)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5796)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5796)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5796)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5796)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5796)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_039110247.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.13262.1,
                                           SRR26643297.19000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  73135386-73135548
            164-366             JAXUCZ010000005.1  73142997-73143199
            367-426             JAXUCZ010000005.1  73151592-73151651
            427-630             JAXUCZ010000005.1  73152711-73152914
            631-908             JAXUCZ010000005.1  73158194-73158471
            909-1041            JAXUCZ010000005.1  73160426-73160558
            1042-1171           JAXUCZ010000005.1  73165478-73165607
            1172-1305           JAXUCZ010000005.1  73169494-73169627
            1306-5796           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5796
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..163
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    70..72
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            164..366
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1374
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform b is encoded by transcript variant 9;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform b"
                     /protein_id="NP_001423941.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVSVPQVYTVLDGVCRHKSPCSL"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1126..>1242
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1126..>1242
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            367..426
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            427..630
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            631..908
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1041
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1171
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1305
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..5796
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg cagaagtacc tctgttgaca
      181 ggaaacaaga ttctgtttca taaagaagat gaaaacaact gggttcctgt taacaaacac
      241 ccaagagacc agcatagacc aatgagcaga gtcaataaga acgtggtctt ggcccttcta
      301 acactgatga gctgtgcctt cctgctgttt cagctgtact actacaagca ctacttgtca
      361 gcacggaatg gaacgggttc atcaaaatcc aaaggaaatc gagttggatt tgatagcaca
      421 caatggcgtg cagttaagaa atttattatg ctgacatcca gccaaaatgt gccggtgttc
      481 cttattgacc cttggattct ggaatcaatt aataaaaatt tcgaacaagt gaaaaatgcc
      541 tctcaaggct cggcctcaga atgcagattt ttctgtgttc cgagagactt cactgcgttc
      601 gcgctgcagt atcacctgtg gaagaatgag gatggatggt ttcagatggc tgagaacatg
      661 ggattccagt gcctgaagat tgaaagcaaa gatcctcggc tggatggaat agactcgctt
      721 tccggaactg agatccctct gcactatgtc tgtaagctgg ccactcacgc catccacttg
      781 gtcgtctttc acgagaggag tggcaactac ctctggcatg gtcacctacg actcaaaggg
      841 cacatggata ggaagtttgt tccttttcga aggctacaat ttggtcgtta tcctggagcc
      901 tttgacaggc cggagttaca gcaggttact gttgatggac tcgacatgct tattccaaaa
      961 gacccagggc gctttctaga agaagtacct cactccagat ttatcgagtg caggtataaa
     1021 gaagcccggg cattccttca gcagtacgtc gatgacaaca ctgtggatgc catggccttt
     1081 cggaagaggg caaaggagtt actgcaacta gcggccaaga cgctgaaggc gctgggagtg
     1141 cccttctggc tgagcagtgg gacgtgtcta ggatggtatc ggcaatgcag tatcattcct
     1201 tatagcaaag atgtcgacct aggaattttc attcaagatt acaaacctga tattgttttg
     1261 gcatttcagg atgcaggact tccactcaaa cacaagtttg ggaaggtatc tgttccccaa
     1321 gtttacactg tgctggacgg agtttgtaga cataaaagtc catgttccct gtgaaacagt
     1381 tgactacatt gaagccaact atggcaaggc ctggaagatc cctgtcaaga cctgggactg
     1441 gaagagctca cccccgaatg tgcagcccaa tggggtctgg cctatttcgg agtgggatga
     1501 agttatccag ttgtactgag aacactgagc tcatgtggga cgtttcccag aaagaaggta
     1561 ggcagctgtt gaaagcacta tgttttctgc ctgatgtgag agccaaagag gagaaatgac
     1621 gagttggaag acagaaaagg ttttctgact catgggccat ctaatcagtt ctgccactca
     1681 gcatttactg aggagtttat acaccaggtg aagtactagg atctggtgaa caggcagaga
     1741 ggaatgagag gccagcttct ctcttgccct gttggtaagc actacaattt tatgttaagg
     1801 gaaactaacc cactctctga agaggtgtac agtagaatgt attccataat gatttttaaa
     1861 atgttaatta atgtttaaac cggaaagtga gctcatcaga caaagctaac aaaggatgtg
     1921 ttagttgaga gtagttcatt tctgcctgcc ctcgggattt aagctgctgt gttagtgtta
     1981 aggttgtggg atatgagtta atattccagt gagtgattag actttgtctc acagagaaaa
     2041 gacagtggcc aactcatttt acaagcagtg tgatacacag ttgacttcaa gcactgggca
     2101 ttctataagg gaggatgaga gccgatagca gctcttgtca agacgtacac tgttttcatc
     2161 tttgagatga acatggatgc ttagatggtg cttgaatccc tgacatcata aggatatttt
     2221 cactgacctg cagtagtact tcctgataaa tcattcagtc gtgctatcca aaagttgtga
     2281 catctcaaag cttccgttcc ttatttcatt cttagtcact cttaaactca aaaatggaag
     2341 ttactcatga atatttttat attttatgaa tgtataactt ttctgccttt aattttaata
     2401 ttgacactaa gtaataatag acatacctct taatttttta aaaataccct ttatttattt
     2461 atcaaccata gttccatgtg tttaatttat ggcctacaca ctaatttatt tagcacaaga
     2521 tatgcctgtt cttctatcca atattacttc acggttccaa aatgaagggt taacgtgaac
     2581 ctggccatta ctccttttcc cagattactg tctttaaagc ctgtgtccat ctctagattt
     2641 tcattctgct gagtgtaata gggcaagggc ttcctaccca caagtactgc acaagtggga
     2701 cccttgacct acactcctga gtccattgta gtggctgcac ataagccatg cagtctcaga
     2761 gagagatgac acagtgagtg cctgcctgcc ttgcctggga ggggagggtc cactccctgc
     2821 tgcttaggga tgtgcttcat ggcaacctgg cagatttccc ttggcacgtg tagttactac
     2881 agcagaaacc aggatagatg agagaatggg ctggcagaaa gaaaagaaaa aagaaagaaa
     2941 aagaaaaact tggaggaagt aacttgaagc cacctatttc caaatttaaa cttcaacatg
     3001 aaaactgtct ttgttggatg atatgcagca gtctccatgc agcctccaag taggaatatt
     3061 gtctctccat aagcatcatc taatcagagt gttacagtta ttagcacaca tgtacccaaa
     3121 tgacaaatca taatcagctc tttcctagaa aataagtcca tagaatacgt acccaagttg
     3181 tagataccca accctacata tttttctgtg tgcgcatgcg tgtgcacgca cacaccccca
     3241 ctcgcacaca ccagataata gtgtttttga ggacaaaccc accctacctg gagaggatca
     3301 tttacttgta ctcaatatca agaagtatgt ttatatcgtg ttccttgaga gctcccacct
     3361 tctgccagga gatcttaccc acccctgttt aagtttcttc tctcatacct gtcgttggag
     3421 tgcaaggtct gccagtgtcc ataatacaag ctcttggtcc tgggcacaga ggttctgtag
     3481 tcttcccttc atagaggatg ggtacctgtt ttccctctgg tttggcttta ggttttaggt
     3541 tccgcccacc gtggagaaat tttcccagaa tttgcaggtg aggtttacct ctaaaaatga
     3601 ctccatgatt cagtcatact gaagtcagtg cttcttaact cttgaactct gctgagtgtc
     3661 ccgagatctt gggtcaggtc tgcccaccac ctgaaccttt tcagatcact tctcttccct
     3721 ccctgaatat gctaactgtt attctcctaa tatgagtgct ttctggtccc atttgcctgg
     3781 actgcttgaa gataccttta cattaactca ttggtagttc tgctgccgag gatctttcag
     3841 agggaccctg agaagcagat gctttctcgg tttacgacag ccatctactt ccctaagcgt
     3901 ggaggacttg ccccgctctt ggttacagtt actgacattg gccactgaga tgaaataata
     3961 gtaactaaaa ctggcctccc tgagagtacc tgagatccgt tcttagtgtg gcctccatga
     4021 cactccagtg cttggtgagt cctccagtgc ctcagtgcct gccattcccc acggaaggcc
     4081 tgaggcgaca gaaaatgctg aggagggatg tttcctcttg tccagaattc tcaggctacc
     4141 gtctcacctt tgtctgggga gggttcagga ggtgggccaa gggaggggaa gccttatcta
     4201 caaaaaatag aacagtttat gtctgaagac atcaccagaa gtcagtttct gactcttgaa
     4261 atgtttaaag gatttaatga tgcatacagt gcttccattc aggcccagcg ttaagtaagt
     4321 actcgccatt tcctagttct cggttccttt gtaacgtgga aggctgcacg acagagttgc
     4381 ttagaactaa aattggggca ctgctgagat ggcttagcag gcaaaagccc ttgtcaccaa
     4441 aagtgacatg agtttgattc ccaggaccca tgtaatggaa ggaaagaatc tcaaattgct
     4501 tgtcatccaa tacacagact ctgatgtgct tggagctcct ctctagcatg agaggacacc
     4561 acacacacac acacacacac acacacacac acacacacac acacacacac acacacacac
     4621 taagtaaata taatggaaag tttttatttt atctaagcat tacaggtcga attatgtgat
     4681 ttttgagtca ttgccatatt ccctccacct gaaacagagc tggttctcac ttagttgacc
     4741 aagtggttgt cttctaatcc tatcctattg tactataccc tttaagcaca gtcagattgc
     4801 tcttaagttt tgtgccttga ttttcaatag tccagctttg ggcagctaac atcactatat
     4861 ataatgattt ggagaaccaa agattttgga atgcttagtt ttatttacct gcctagtctg
     4921 tatagaaatg tgggctagtt agtctaattg cccagcatgt gtgaggtctg gattcagtac
     4981 aaagcaccag aagtctgaga cagaagactt agcacatgct gaaggccagc ttgggctacc
     5041 tagtgagtac cagcctatcc tgggctacag tgtaagaccc tatattgatt gaggacacag
     5101 gagggaagag agaaacagag acagaatgag aatatactcc tgtcagccat ctgcccatag
     5161 atgtatgttt taatctaagc gaggcaaaat caggatatat agtgtggatt tttaaatagt
     5221 taattgtaga caattaacag ccaattcgat attgatgctt tttgtatagg accaataggc
     5281 aagtgtaatg tgttgagaaa cgtatttcca aacactcaga acacctaggc taaagcctgc
     5341 tcctgtaact cctggaccta acgtagaagg atcgaagaat ctctgtgagg gagggcccat
     5401 gtagtgacgc agacttccgt ctacttatga gtaactttcg cggaagggaa agctttgtca
     5461 tataaagtat tctgtcaagc gctttaagaa tgataagcct gtacaaactt atgacaatgt
     5521 gttctaagca tgggaaccag ttcatgagtt tgttaaatgt agttctgtca acatgggaca
     5581 tatgacgatg acatgtgtat tgtatgtgaa ctttctagac aaagttatgt tttaaacaag
     5641 ataaaactgg tatatgctta ccaggttaag atttggtttt gtcctcaggt atagtttatg
     5701 gtactactga aatagtttta atgttattac tctgatctga atttgtaata tatagtctac
     5761 tttgggatga ttaataaaaa tttttaatct cttgtg
//
LOCUS       NM_001011973            1976 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus actin-like 7a (Actl7a), mRNA.
ACCESSION   NM_001011973 XM_232920
VERSION     NM_001011973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Afsharpad,M., Nowroozi,M.R., Mobasheri,M.B., Ayati,M.,
            Nekoohesh,L., Saffari,M., Zendehdel,K. and Modarressi,M.H.
  TITLE     Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for
            Transitional Cell Carcinoma of Bladder
  JOURNAL   Pathol Oncol Res 25 (1), 191-199 (2019)
   PUBMED   29058301
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Fu,J., Yao,R., Luo,Y., Yang,D., Cao,Y., Qiu,Y., Song,W., Miao,S.,
            Gu,Y. and Wang,L.
  TITLE     Immune Infertility Should Be Positively Diagnosed Using an Accurate
            Method by Monitoring the Level of Anti-ACTL7a Antibody
  JOURNAL   Sci Rep 6, 22844 (2016)
   PUBMED   26957350
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Boeda,B., Knowles,P.P., Briggs,D.C., Murray-Rust,J., Soriano,E.,
            Garvalov,B.K., McDonald,N.Q. and Way,M.
  TITLE     Molecular recognition of the Tes LIM2-3 domains by the
            actin-related protein Arp7A
  JOURNAL   J Biol Chem 286 (13), 11543-11554 (2011)
   PUBMED   21278383
  REMARK    GeneRIF: Molecular recognition of the Tes LIM2-3 domains by the
            actin-related protein Arp7A.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Tanaka,H., Iguchi,N., Egydio de Carvalho,C., Tadokoro,Y.,
            Yomogida,K. and Nishimune,Y.
  TITLE     Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are
            differentially expressed in the cytoplasm and nucleus of mouse
            haploid germ cells
  JOURNAL   Biol Reprod 69 (2), 475-482 (2003)
   PUBMED   12672658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 19, 2025 this sequence version replaced NM_001011973.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360186.1932091.1, BC082101.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1976              JAXUCZ010000005.1  76244141-76246116
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..1976
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="actin-like 7a"
                     /db_xref="GeneID:298017"
                     /db_xref="RGD:1304697"
     exon            1..1976
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1370
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /codon_start=1
                     /product="actin-like protein 7A"
                     /protein_id="NP_001011973.1"
                     /db_xref="GeneID:298017"
                     /db_xref="RGD:1304697"
                     /translation="MSLDAVWAPQTANIGDGPAKKASDQTSMQTQVLQTASLRDGPAK
                     RAVWVRRDNAEKEEPVKSAVSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKIST
                     TVGKPYMETAKTGDNRKETFVGRELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFR
                     QEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTS
                     GLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTNYLMNLMNNCGKHFSEDHLSI
                     VEDIKTKCCFVALDPIEEKKIPPSEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIK
                     SMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTP
                     QVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF"
     misc_feature    48..128
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q641W9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    63..257
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="Actin-like protein 7A N-terminus; Region: ACTL7A_N;
                     pfam16840"
                     /db_xref="CDD:465280"
     misc_feature    63..257
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="Actin-like protein 7A N-terminus; Region: ACTL7A_N;
                     pfam16840"
                     /db_xref="CDD:465280"
     misc_feature    153..215
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q641W9.1);
                     Region: Required for interaction with TES.
                     /evidence=ECO:0000250|UniProtKB:Q9Y615"
     misc_feature    261..1364
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="nucleotide-binding domain (NBD) of the actin-like
                     protein 7 (ACTL7)-like family; Region: ASKHA_NBD_ACTL7;
                     cd10214"
                     /db_xref="CDD:466819"
     misc_feature    261..1364
                     /gene="Actl7a"
                     /gene_synonym="Arp7a; T-actin 2; Tact2"
                     /note="nucleotide-binding domain (NBD) of the actin-like
                     protein 7 (ACTL7)-like family; Region: ASKHA_NBD_ACTL7;
                     cd10214"
                     /db_xref="CDD:466819"
ORIGIN      
        1 ctttcaggcc ttgtagccag caggatcgag agctttctga gagcagtatg tctctggatg
       61 ctgtgtgggc tccacagaca gcaaacatcg gggacgggcc tgccaagaaa gctagtgacc
      121 agacctccat gcagacacag gtcctccaga ctgcctccct aagagatggc ccagcaaaga
      181 gggcagtatg ggtccgtcgg gacaatgctg agaaagaaga gcctgttaag tcagctgtgt
      241 ccaaggatag gccaaggcta gaggtgacca aagcagtggt tgtggaccta ggtactggct
      301 tctgtaaatg tggctttgct ggcctgccaa agcccactca taagatctca acaacagtgg
      361 gcaagcccta catggagaca gccaagactg gggataatcg caaagagacc tttgtggggc
      421 gtgagctctt taacccagat atacatctca aactggtcaa ccccctgcgt catggcatca
      481 ttgtggactg ggacacagta caggacatct gggaatacct cttccgacag gagatgaaga
      541 tcgccccaga ggaacatgcg gtcctggttt cagacccacc actgagtcct cacaccaaca
      601 gagagaagta cgccgagatg ctgtttgaga ccttcaacac gcctgcaatg cacatcgcct
      661 accagtcccg cctgtccatg tactcctacg gacgcacctc tggcctggtg gtggaggtcg
      721 gacatggtgt gtcctatgtg gtccccatct atgagggtta tcctttgccc agcatcacag
      781 ggaggctaga ctacgcggga tctgacctaa cgaactacct gatgaacctg atgaacaact
      841 gtggaaaaca cttctctgag gaccacctta gtattgtgga agacatcaag acgaaatgct
      901 gctttgtggc cctggacccc attgaagaga agaaaatccc tcccagtgaa cacgagatcc
      961 attatactct gcctgatggg aaagagatcc gtctgggtca ggagaggttc ctctgctcag
     1021 agatgttctt caagccatct ctaatcaagt ccatgcagct gggcctccac acccaaaccg
     1081 tgtcctgcct taacaagtgt gacattgcac tcaaacgaga cctcatgggg aacatcctgc
     1141 tctgtggggg cagcactatg ctcaggggtt tccccaaccg tctgcagaag gaactgagca
     1201 gcatgtgtcc caacgacacc ccacaggtaa atgtgctgcc cgagagagac accgcagtct
     1261 ggactggtgg ttctatcctg gcctcgctcc agggttttca accactgtgg gtccatcgcc
     1321 ttgaatacga ggaacatggg cctttcttcc tctacagaag gtgcttctga acaggtgcaa
     1381 cacgtacgct gtggtgacca tgtgctagct ttaccgtccg agggctgaac ctttcacacg
     1441 tggtgtcaag ctggcatgtt catttctgta gcattaaaaa ccccttgtgt ctgtcccctt
     1501 cccttcagag tgtgtccgta tttcctgaca tagtaagagc cacatggatg cgtgcatcgt
     1561 cttaaaaagt gcgaaagcct gggcgtggaa gggctgtatg aaagaatcac acgcacgaat
     1621 gctaactgct cagaaagtct ctcccaggag aaacttgctc taacattagt ctgcccgttg
     1681 tgcttcccac aacgttgttg ttaaaatata cttaaggaaa aatgtcatca aaacaaatta
     1741 agagtaaatg atgttgaagg ataaagaggc tctccatcca cagtaccctg cggaatgcta
     1801 aacgggttta ttctccggca aaagcagcac cgtatctcag ctaagtattc ttgctaattg
     1861 aggcatcaac acaggatgtg acttttgtgc ttaaaagctc gcactttggg actacactca
     1921 ggtcctgaac acccagttta gttgccagtt aataaagact ttatggcttg aatcca
//
LOCUS       NM_001013035            1373 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus prohibitin 2 (Phb2), mRNA.
ACCESSION   NM_001013035 XM_342755
VERSION     NM_001013035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Liu,S., Zhang,R., Zhang,L., Yang,A., Guo,Y., Jiang,L., Wang,H.,
            Xu,S. and Zhou,H.
  TITLE     Oxidative stress suppresses PHB2-mediated mitophagy in beta-cells
            via the Nrf2/PHB2 pathway
  JOURNAL   J Diabetes Investig 15 (5), 559-571 (2024)
   PUBMED   38260951
  REMARK    GeneRIF: Oxidative stress suppresses PHB2-mediated mitophagy in
            beta-cells via the Nrf2/PHB2 pathway.
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Zheng,X., Liu,K., Xie,Q., Xin,H., Chen,W., Lin,S., Feng,D. and
            Zhu,T.
  TITLE     PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106-126 via
            PINK1/Parkin-Dependent Mitophagy
  JOURNAL   Int J Mol Sci 24 (21), 15919 (2023)
   PUBMED   37958902
  REMARK    GeneRIF: PHB2 Alleviates Neurotoxicity of Prion Peptide
            PrP[106-126] via PINK1/Parkin-Dependent Mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Vila,E., Pinacho,R., Prades,R., Tarrago,T., Castro,E.,
            Munarriz-Cuezva,E., Meana,J.J., Eugui-Anta,A., Roldan,M.,
            Vera-Montecinos,A. and Ramos,B.
  TITLE     Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in
            Psychosis Models: Relationship to Cognitive Deficits in
            Schizophrenia
  JOURNAL   Int J Mol Sci 24 (7), 6016 (2023)
   PUBMED   37046989
  REMARK    GeneRIF: Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2
            Levels in Psychosis Models: Relationship to Cognitive Deficits in
            Schizophrenia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Jia,Y., Wang,M., Mao,C., Yu,F., Wang,Y., Xiao,R., Jiang,C.,
            Zheng,L., Xu,Q., Zheng,M., Fu,Y., Hu,Q. and Kong,W.
  TITLE     COMP-prohibitin 2 interaction maintains mitochondrial homeostasis
            and controls smooth muscle cell identity
  JOURNAL   Cell Death Dis 9 (6), 676 (2018)
   PUBMED   29867124
  REMARK    GeneRIF: COMP-prohibitin 2 interaction in mitochondria plays an
            important role in maintaining the contractile phenotype of Vascular
            smooth muscle cells by regulating mitochondrial oxidative
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Zhou,T.B., Ou,C., Rong,L. and Drummen,G.P.
  TITLE     Effect of all-trans retinoic acid treatment on prohibitin and
            renin-angiotensin-aldosterone system expression in hypoxia-induced
            renal tubular epithelial cell injury
  JOURNAL   J Renin Angiotensin Aldosterone Syst 15 (3), 243-249 (2014)
   PUBMED   25031298
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Kurtev,V., Margueron,R., Kroboth,K., Ogris,E., Cavailles,V. and
            Seiser,C.
  TITLE     Transcriptional regulation by the repressor of estrogen receptor
            activity via recruitment of histone deacetylases
  JOURNAL   J Biol Chem 279 (23), 24834-24843 (2004)
   PUBMED   15140878
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Coates,P.J., Nenutil,R., McGregor,A., Picksley,S.M., Crouch,D.H.,
            Hall,P.A. and Wright,E.G.
  TITLE     Mammalian prohibitin proteins respond to mitochondrial stress and
            decrease during cellular senescence
  JOURNAL   Exp Cell Res 265 (2), 262-273 (2001)
   PUBMED   11302691
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Montano,M.M., Ekena,K., Delage-Mourroux,R., Chang,W., Martini,P.
            and Katzenellenbogen,B.S.
  TITLE     An estrogen receptor-selective coregulator that potentiates the
            effectiveness of antiestrogens and represses the activity of
            estrogens
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6947-6952 (1999)
   PUBMED   10359819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083705.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342755.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083705.1, CF110063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1373
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="prohibitin 2"
                     /db_xref="GeneID:114766"
                     /db_xref="RGD:620203"
     exon            1..253
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    91..93
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="upstream in-frame stop codon"
     CDS             127..1026
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="B-cell receptor associated protein 37; B-cell
                     receptor-associated protein BAP37"
                     /codon_start=1
                     /product="prohibitin-2"
                     /protein_id="NP_001013053.1"
                     /db_xref="GeneID:114766"
                     /db_xref="RGD:620203"
                     /translation="MAQNLKDLAGRLPSGPRGMGTALKLLLGAGAVAYGVRESVFTVE
                     GGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMV
                     NISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQV
                     SLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAK
                     QEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTAD
                     NLVLNLQDESFTRGSDSLIKGKK"
     misc_feature    130..132
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     misc_feature    181..273
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIH7.1);
                     Region: Necessary for transcriptional repression.
                     /evidence=ECO:0000250|UniProtKB:Q99623"
     misc_feature    244..831
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="Prohibitin family; SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; Region:
                     SPFH_prohibitin; cd03401"
                     /db_xref="CDD:259799"
     misc_feature    244..831
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="Prohibitin family; SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; Region:
                     SPFH_prohibitin; cd03401"
                     /db_xref="CDD:259799"
     misc_feature    508..510
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); phosphorylation site"
     misc_feature    565..567
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O35129; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     misc_feature    574..648
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIH7.1);
                     Region: Necessary for transcriptional repression.
                     /evidence=ECO:0000250|UniProtKB:Q99623"
     misc_feature    577..579
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); phosphorylation site"
     misc_feature    724..726
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O35129; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     misc_feature    832..834
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O35129; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     misc_feature    874..876
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     misc_feature    910..912
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O35129; propagated from
                     UniProtKB/Swiss-Prot (Q5XIH7.1); acetylation site"
     exon            254..338
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            339..418
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            419..603
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            604..733
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            734..837
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            838..915
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            916..992
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            993..998
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1350
                     /gene="Phb2"
                     /gene_synonym="Bap; Bap-37; Bap37; Bcap27; Bcap37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctcccgcg agctctaagg cctccaatcc tcgtgtgcaa ggcgaggtgt gtaaactgga
       61 gtggggtaga agctggcggg caccccctcc tgaccactgg tgccgccgcc ttcaggagaa
      121 tcagacatgg cccagaactt aaaggaccta gcgggacgcc tgccctccgg gcctcggggc
      181 atgggcacgg cgctgaagct gctgctgggg gccggggctg tggcctacgg cgtccgtgag
      241 tccgtattca ctgtggaagg tggtcacaga gccatcttct ttaatcgtat tggtggcgta
      301 caacaggaca caatcctagc cgaaggcctt cacttcagga ttccctggtt ccagtacccc
      361 atcatctatg acattcgggc cagacctcga aaaatctcct cccccacagg ctccaaagac
      421 ctgcagatgg tgaacatctc cctgcgtgta ctgtctcggc ccaatgccca ggagctcccc
      481 agcatgtacc agcgcctagg cctagactat gaggagcgag tgctgccgtc cattgttaat
      541 gaggtgctca agagtgtggt ggccaagttc aacgcctcgc agctcattac ccagcgggct
      601 caggtgtctc tgttgatccg aagagagctg acagagcgtg ccaaggactt cagcctcatc
      661 ctggacgatg tagctatcac agagctaagc ttcagccgag agtacacagc tgctgtagaa
      721 gccaaacaag tggcccagca ggaagcccag agggcccagt ttttggtgga gaaagcaaag
      781 caggaacaac gacagaagat tgtgcaggct gagggggagg cggaggctgc taagatgctt
      841 ggagaagcac tgagcaagaa tcctggctat atcaagctcc gaaagatccg ggctgcccag
      901 aacatctcta aaacgatcgc cacatcacag aaccggatct atctcacagc tgacaacctt
      961 gtgctgaatc tgcaggatga aagctttact cggggaagtg acagcctcat taagggtaag
     1021 aagtgagtgt ggacatcaag aaccccacca ccagagaagt tggcacactt ctccagtttg
     1081 gaggggccag ctagggggtc aagcataccc caccctgacc caagcatcat gtgatggatt
     1141 cttctgtatc tgctctcttg gattaaggaa gactgaagac caaccctttc agaggggttt
     1201 tcctccttct tgtattggct gggaaggggg ggggacagga gacagtgtga tttctcagtg
     1261 atttcctgta gtgttgtccc tctccctgaa tggggggaga taaccaccat gccaggaagt
     1321 ctcaataaaa tttttattac ttaaactaaa aaaaaaaaaa aaaaaaaaaa aaa
//
LOCUS       NM_019318               1945 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus MAF bZIP transcription factor (Maf), transcript
            variant 2, mRNA.
ACCESSION   NM_019318 XM_001078144
VERSION     NM_019318.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Kim,M., Wende,H., Walcher,J., Kuhnemund,J., Cheret,C., Kempa,S.,
            McShane,E., Selbach,M., Lewin,G.R. and Birchmeier,C.
  TITLE     Maf links Neuregulin1 signaling to cholesterol synthesis in
            myelinating Schwann cells
  JOURNAL   Genes Dev 32 (9-10), 645-657 (2018)
   PUBMED   29748249
  REMARK    GeneRIF: a crucial role of the transcription factor Maf in
            myelination and cholesterol biosynthesis and show that Maf acts
            downstream from Neuregulin1
            Erratum:[Genes Dev. 2018 Aug 1;32(15-16):1101. doi:
            10.1101/gad.318477.118. PMID: 30068704]
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Narumi,Y., Nishina,S., Tokimitsu,M., Aoki,Y., Kosaki,R., Wakui,K.,
            Azuma,N., Murata,T., Takada,F., Fukushima,Y. and Kosho,T.
  TITLE     Identification of a novel missense mutation of MAF in a Japanese
            family with congenital cataract by whole exome sequencing: a
            clinical report and review of literature
  JOURNAL   Am J Med Genet A 164A (5), 1272-1276 (2014)
   PUBMED   24664492
  REMARK    Review article
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Aguayo-Mazzucato,C., Zavacki,A.M., Marinelarena,A.,
            Hollister-Lock,J., El Khattabi,I., Marsili,A., Weir,G.C.,
            Sharma,A., Larsen,P.R. and Bonner-Weir,S.
  TITLE     Thyroid hormone promotes postnatal rat pancreatic beta-cell
            development and glucose-responsive insulin secretion through MAFA
  JOURNAL   Diabetes 62 (5), 1569-1580 (2013)
   PUBMED   23305647
  REMARK    GeneRIF: Data suggest that triiodothyronine (T3) acts as
            physiological regulator of functional maturation of islet
            beta-cells via induction of MAFA/c-Maf; T3 has a direct
            receptor-ligand interaction with MAFA/c-Maf promoter.
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Motomura,Y., Kitamura,H., Hijikata,A., Matsunaga,Y., Matsumoto,K.,
            Inoue,H., Atarashi,K., Hori,S., Watarai,H., Zhu,J., Taniguchi,M.
            and Kubo,M.
  TITLE     The transcription factor E4BP4 regulates the production of IL-10
            and IL-13 in CD4+ T cells
  JOURNAL   Nat Immunol 12 (5), 450-459 (2011)
   PUBMED   21460847
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Ring,B.Z., Cordes,S.P., Overbeek,P.A. and Barsh,G.S.
  TITLE     Regulation of mouse lens fiber cell development and differentiation
            by the Maf gene
  JOURNAL   Development 127 (2), 307-317 (2000)
   PUBMED   10603348
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Kawauchi,S., Takahashi,S., Nakajima,O., Ogino,H., Morita,M.,
            Nishizawa,M., Yasuda,K. and Yamamoto,M.
  TITLE     Regulation of lens fiber cell differentiation by transcription
            factor c-Maf
  JOURNAL   J Biol Chem 274 (27), 19254-19260 (1999)
   PUBMED   10383433
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Kim,J.I., Ho,I.C., Grusby,M.J. and Glimcher,L.H.
  TITLE     The transcription factor c-Maf controls the production of
            interleukin-4 but not other Th2 cytokines
  JOURNAL   Immunity 10 (6), 745-751 (1999)
   PUBMED   10403649
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Matsushima-Hibiya,Y., Nishi,S. and Sakai,M.
  TITLE     Rat maf-related factors: the specificities of DNA binding and
            heterodimer formation
  JOURNAL   Biochem Biophys Res Commun 245 (2), 412-418 (1998)
   PUBMED   9571165
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Sakai,M., Imaki,J., Yoshida,K., Ogata,A., Matsushima-Hibaya,Y.,
            Kuboki,Y., Nishizawa,M. and Nishi,S.
  TITLE     Rat maf related genes: specific expression in chondrocytes, lens
            and spinal cord
  JOURNAL   Oncogene 14 (6), 745-750 (1997)
   PUBMED   9038383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019318.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U56242.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1945              JAXUCZ010000019.1  60619412-60621356   c
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1945
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="MAF bZIP transcription factor"
                     /db_xref="GeneID:54267"
                     /db_xref="RGD:3034"
     exon            1..1945
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="upstream in-frame stop codon"
     CDS             178..1287
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor Maf; C-Maf; proto-oncogene c-maf;
                     transcription factor Maf-2; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog; bZip transcription factor
                     c-maf"
                     /codon_start=1
                     /product="transcription factor Maf isoform 2"
                     /protein_id="NP_062191.2"
                     /db_xref="GeneID:54267"
                     /db_xref="RGD:3034"
                     /translation="MASELAMNNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIIS
                     QCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLN
                     PEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPA
                     AAVVSAVIAAAAAQSGGAPHYHHHHHHATGHHHHPTAGAPGAAGSASASASGAGGAGG
                     GGPASAGGGGGGGGGGTAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRG
                     VSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLV
                     RERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFM"
     misc_feature    346..423
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    433..534
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Maf N-terminal region; Region: Maf_N; pfam08383"
                     /db_xref="CDD:462456"
     misc_feature    433..534
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Maf N-terminal region; Region: Maf_N; pfam08383"
                     /db_xref="CDD:462456"
     misc_feature    553..1284
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Represses ARE-mediated transcription.
                     /evidence=ECO:0000250"
     misc_feature    700..906
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1012..1218
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; Region:
                     bZIP_Maf_large; cd14718"
                     /db_xref="CDD:269866"
     misc_feature    1012..1218
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; Region:
                     bZIP_Maf_large; cd14718"
                     /db_xref="CDD:269866"
     misc_feature    1012..1218
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269866"
     misc_feature    1012..1218
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269866"
     misc_feature    1027..1104
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     misc_feature    order(1033..1035,1042..1050,1054..1062,1066..1074,
                     1078..1083,1087..1092)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     misc_feature    order(1033..1035,1042..1050,1054..1062,1066..1074,
                     1078..1083,1087..1092)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     misc_feature    order(1090..1092,1111..1113,1120..1125,1132..1137,
                     1141..1146,1153..1158,1162..1167,1174..1176,1183..1188,
                     1195..1200,1204..1209)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269866"
     misc_feature    order(1090..1092,1111..1113,1120..1125,1132..1137,
                     1141..1146,1153..1158,1162..1167,1174..1176,1183..1188,
                     1195..1200,1204..1209)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269866"
     misc_feature    1111..1176
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
ORIGIN      
        1 gggcagggcg gggggtgtgt gcacgctcga gctttcgggc cacagccacc gccgcgcgag
       61 ctagaagcgc cctagcccgg caagctggct cacccgctgg ccacccagca cagcccgctg
      121 gcccctctcc tgcagcccat ctggcggagc ggcggcggcg gtggcggagg caggaggatg
      181 gcttcagaac tggcaatgaa caattccgac ctgcccacca gtcccctggc catggaatat
      241 gttaatgact tcgatctgat gaagtttgaa gtgaaaaagg aaccggtgga gaccgaccgc
      301 atcatcagcc agtgcggccg tctcatcgcc gggggctcgc tgtcctccac ccccatgagc
      361 acgccctgca gctcggtgcc cccgtccccc agcttctcgg cgcccagccc gggctcgggc
      421 agcgaacaga aggcgcacct ggaagactac tactggatga ccggctaccc gcagcagctc
      481 aacccggagg cgctgggctt cagcccggag gacgcagtcg aggcgctcat cagcaatagc
      541 caccagctcc agggtggctt cgatggctat gcgcggggag cgcagcagct ggccgcggca
      601 gcgggggccg gcgccggcgc ctccctgggc ggcagcggcg aggagatggg ccccgccgcc
      661 gccgtggtgt ccgccgtgat cgccgcggcc gccgcgcaga gcggcggggc acctcactac
      721 catcaccacc accaccacgc cacggggcac caccaccacc cgacggccgg cgccccggga
      781 gccgcgggta gcgcgtccgc ctctgcgagc ggcgcgggtg gcgcgggcgg cggtggcccg
      841 gccagcgccg ggggcggcgg cggcggcggc ggcgggggca cggcgggggc ggggggcgcc
      901 ctgcacccgc accatgccgc gggaggcctg cacttcgacg accgcttctc ggacgagcag
      961 ttggtgacca tgtcggtgcg tgagctgaac cggcagctgc gcggggtcag caaggaggag
     1021 gtgatccgac tgaagcagaa gaggcggacc ctgaaaaacc gcggctatgc ccagtcctgc
     1081 cgcttcaaga gggtgcagca gagacacgtc ctggagtcgg agaagaacca gctgctgcag
     1141 caggtcgacc acctcaagca ggagatctcc aggctggtgc gcgaaaggga cgcctacaag
     1201 gagaaatacg agaagttggt gagcagcggg ttccgagaaa acggctcgag cagcgacaac
     1261 ccttcctctc ccgaattttt catgtgagtg tgacacgcga tcccagctag ccaccttgtt
     1321 aaatgctccg tgggggtccg gctcctgagt gggcttgcca gtttgcaggg ccacgctcgc
     1381 caccacctcg ccccctcccc tggcgagttt gctccccttg gccctgcacg cacacacaca
     1441 cacacacaca cacacacaca cacacacaca cacacacaca cacacacata cacacacaca
     1501 cacacacagc aagcttgtgg tggtggtggt ggctcttttg agttggggag ggaaagggta
     1561 tctggctcat ggattgccaa cctgaattcc cctgtaactt gctagcttgg ttgttttggt
     1621 cttttttatt attattatta ctctttttac accgcctacc ccacacatac cctggacttg
     1681 cacaagggtc aaagatctga gcaggatact tcatgtagga cataactcac ctttgaaccc
     1741 ggccatcaag cgcctgtata ttttttttct tcttcttctt tagttcatga gctggtgttc
     1801 attctctgtg tgtgtgtttt tttattttgt ttggattttc ttttttcttc tttgtttttg
     1861 tttattatta ctaatttttt tggagcttgc tgtgtttccc agcctctgcc ctccctccct
     1921 ctgcaccatg ttcttgagat aaaag
//
LOCUS       NM_182670               1399 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus ras homolog family member A like 1 (Rhoal1),
            mRNA.
ACCESSION   NM_182670
VERSION     NM_182670.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Zhang,N., Liang,J., Tian,Y., Yuan,L., Wu,L., Miao,S., Zong,S. and
            Wang,L.
  TITLE     A novel testis-specific GTPase serves as a link to proteasome
            biogenesis: functional characterization of RhoS/RSA-14-44 in
            spermatogenesis
  JOURNAL   Mol Biol Cell 21 (24), 4312-4324 (2010)
   PUBMED   20980621
  REMARK    GeneRIF: RSA-14-44 associates with PSMB5, a catalytic subunit of
            the proteasome, in a series of stage-specific spermatogenic cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK603687.1 and BC083656.1.
            
            On Nov 23, 2005 this sequence version replaced NM_182670.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC083656.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CK603687.1         6-16
            12-1399             BC083656.1         1-1388
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..1399
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="ras homolog family member A like 1"
                     /db_xref="GeneID:297173"
                     /db_xref="RGD:735071"
     exon            1..1373
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    98..100
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="upstream in-frame stop codon"
     CDS             146..727
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /codon_start=1
                     /product="ras homolog gene family, member A"
                     /protein_id="NP_872611.2"
                     /db_xref="GeneID:297173"
                     /db_xref="RGD:735071"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVLLICFSIGNPDSFGNIPHKWIPE
                     VKHFCPNVPIILVGSKKDLRNDLNTIQELAKRKQEPVKPEQGRDLANSIGAFEYVECS
                     AKTKDGVRKVFEKATRAALQTNRVKKKTGCFVF"
     misc_feature    158..682
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    158..682
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Ras homology family A (RhoA)-like includes RhoA,
                     RhoB and RhoC; Region: RhoA_like; cd01870"
                     /db_xref="CDD:206662"
     misc_feature    order(158..160,245..247,254..259,266..268,272..274,
                     278..280,305..307,317..322,326..334,341..343,347..349,
                     359..361)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(158..160,245..247,254..259,266..268,272..274,
                     278..280,305..307,317..322,326..334,341..343,347..349,
                     359..361)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    179..202
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    179..202
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G1 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(188..205,245..250,254..256,320..325,497..499,
                     503..505,626..631)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(188..205,245..250,254..256,320..325,497..499,
                     503..505,626..631)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206662"
     misc_feature    order(212..214,218..232,269..274,278..286,299..307,
                     632..637,647..652,659..661)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(212..214,218..232,269..274,278..286,299..307,
                     632..637,647..652,659..661)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="PKN/PRK1 effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(245..247,251..253,257..262,332..343,350..352,
                     359..361,425..427)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(245..247,251..253,257..262,332..343,350..352,
                     359..361,425..427)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GAP (GTPase-activating protein) interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    245..271
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    245..271
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(254..259,326..328,341..343,347..352,356..361,
                     368..370,458..463,467..469)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(254..259,326..328,341..343,347..352,356..361,
                     368..370,458..463,467..469)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="GDI (guanine nucleotide dissociation inhibitor)
                     interaction site [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    254..256
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    254..256
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G2 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(260..262,338..352,359..361,434..436,446..448,
                     458..460)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(260..262,338..352,359..361,434..436,446..448,
                     458..460)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Mdia effector interaction site [active]"
                     /db_xref="CDD:206662"
     misc_feature    order(260..265,338..343,347..352,359..361)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    order(260..265,338..343,347..352,359..361)
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Rho kinase (ROCK) effector interaction site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:206662"
     misc_feature    320..331
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    320..331
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G3 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    329..382
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    329..382
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206662"
     misc_feature    494..505
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    494..505
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G4 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    623..631
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
     misc_feature    623..631
                     /gene="Rhoal1"
                     /gene_synonym="RSA-14-44"
                     /note="G5 box; other site"
                     /db_xref="CDD:206662"
ORIGIN      
        1 ttggttttct cttgactctg ccacctcctg ctgagctggg cttcaaaggt ggtggctcag
       61 gataggtgtc ctctgcacta ataggcctac ctgggtgtag tctgacagcc tgtggtctga
      121 gaagtcccag gtgctttgta cagcaatggc tgccatccgg aagaaactgg tgattgtggg
      181 agatggagct tgtggaaaaa catgcttgct catcgtcttc agcaaggacc agtttcctga
      241 tgtttatgtg cccacagtgt ttgagaacta tgtggctgat atcgaagtgg atggaaaaca
      301 ggtggagttg gccctctggg acacagctgg tcaagaagat tatgatcgct tgaggccact
      361 ctcctatccg gacactgatg tcctcttgat atgtttctcc attggcaacc ctgatagctt
      421 tgggaacatc ccacacaaat ggataccaga agtaaagcat ttctgtccca acgtgcccat
      481 catcctggtc gggagcaaga aggatcttcg gaatgacttg aacacaatac aagagttagc
      541 caagaggaaa caagagccgg tgaaacctga acaaggccga gatttggcga acagcattgg
      601 cgctttcgag tatgtggagt gttctgcaaa gaccaaagat ggagtgagaa aggtctttga
      661 aaaagccacc agggctgctc tgcaaacgaa ccgtgtgaag aaaaagactg gctgctttgt
      721 cttttgaagt ctttgtgcaa acacagccct agtacagtta attttcaagt gctatttacg
      781 aatgttattg tgtaattgct agcctttttg tttatttata tatccaagat tacaggtcag
      841 aagtcatctt gctactaatg tttggaaatc aactgtgatt attaatgaca ttcattctgt
      901 ctgaccttcc agggtcctga ctcttctgta acagaccatt ctgcatttca cctgaaaccc
      961 aaggcactaa ttgaagaact tattatctgt agaaagagag atggtaactt catcatttag
     1021 actgtaacta ctttctgacc accctaccat ccatatatga gctgagaaga aagctgttga
     1081 gtcaccactt gagtgtttac tccctaacaa ctttaatcac catccttatt ctcttcgaaa
     1141 tgtctctcca tgcatctgtg gtagagtaac agctctgtgg ctccatgtta gctaccttat
     1201 agttactgtg caattagtgc cacttaatgt atgtcaccag aagaactaag atctacccca
     1261 gactagatgt agcatttttg gaatacttgg attttctgat actgatattt gtcattcccg
     1321 cagcaagtat actggttgaa agaatttgga aataaagtca tatggaaaat tgaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaa
//
LOCUS       NM_017009               2714 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus glial fibrillary acidic protein (Gfap), mRNA.
ACCESSION   NM_017009 XM_346410
VERSION     NM_017009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Dandi,Epsilon., Theotokis,P., Petri,M.C., Sideropoulou,V.,
            Spandou,E. and Tata,D.A.
  TITLE     Environmental enrichment initiated in adolescence restores the
            reduced expression of synaptophysin and GFAP in the hippocampus of
            chronically stressed rats in a sex-specific manner
  JOURNAL   Dev Psychobiol 65 (7), e22422 (2023)
   PUBMED   37796476
  REMARK    GeneRIF: Environmental enrichment initiated in adolescence restores
            the reduced expression of synaptophysin and GFAP in the hippocampus
            of chronically stressed rats in a sex-specific manner.
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Gok,E. and Deveci,E.
  TITLE     Histopathological evaluation of IBA-1, GFAP activity in the brain
            cortex of rats administered cadmium chloride
  JOURNAL   Arch Ital Biol 160 (1-2), 20-27 (2022)
   PUBMED   35913387
  REMARK    GeneRIF: Histopathological evaluation of IBA-1, GFAP activity in
            the brain cortex of rats administered cadmium chloride.
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Aamodt,A.H., Hogestol,E.A., Popperud,T.H., Holter,J.C.,
            Dyrhol-Riise,A.M., Tonby,K., Stiksrud,B., Quist-Paulsen,E.,
            Berge,T., Barratt-Due,A., Aukrust,P., Heggelund,L., Blennow,K.,
            Zetterberg,H. and Harbo,H.F.
  TITLE     Blood neurofilament light concentration at admittance: a potential
            prognostic marker in COVID-19
  JOURNAL   J Neurol 268 (10), 3574-3583 (2021)
   PUBMED   33743046
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Othman,H., Lopez-Furelos,A., Leiro-Vidal,J.M., Ammari,M., Sakly,M.,
            Abdelmelek,H., Salas-Sanchez,A.A., Ares-Pena,F. and Lopez-Martin,E.
  TITLE     Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70,
            Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
  JOURNAL   Int J Mol Sci 22 (10), 5103 (2021)
   PUBMED   34065959
  REMARK    GeneRIF: Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70,
            Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Tsyba,D.L., Kirik,O.V., Kolpakova,M.E., Yakovleva,A.A. and
            Korzhevskii,D.E.
  TITLE     Expression of Nestin and Glial Fibrillary Acidic Protein in the
            Marginal Ischemic Zone of the Brain in SHR Rats
  JOURNAL   Bull Exp Biol Med 169 (4), 576-581 (2020)
   PUBMED   32910393
  REMARK    GeneRIF: Expression of Nestin and Glial Fibrillary Acidic Protein
            in the Marginal Ischemic Zone of the Brain in SHR Rats.
REFERENCE   6  (bases 1 to 2714)
  AUTHORS   McCall,M.A., Gregg,R.G., Behringer,R.R., Brenner,M., Delaney,C.L.,
            Galbreath,E.J., Zhang,C.L., Pearce,R.A., Chiu,S.Y. and Messing,A.
  TITLE     Targeted deletion in astrocyte intermediate filament (Gfap) alters
            neuronal physiology
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6361-6366 (1996)
   PUBMED   8692820
REFERENCE   7  (bases 1 to 2714)
  AUTHORS   Molthagen,M., Schachner,M. and Bartsch,U.
  TITLE     Apoptotic cell death of photoreceptor cells in mice deficient for
            the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na,
            K-ATPase)
  JOURNAL   J Neurocytol 25 (4), 243-255 (1996)
   PUBMED   8793730
REFERENCE   8  (bases 1 to 2714)
  AUTHORS   Condorelli,D.F., Nicoletti,V.G., Barresi,V., Caruso,A.,
            Conticello,S., de Vellis,J. and Giuffrida Stella,A.M.
  TITLE     Tissue-specific DNA methylation patterns of the rat glial
            fibrillary acidic protein gene
  JOURNAL   J Neurosci Res 39 (6), 694-707 (1994)
   PUBMED   7897704
REFERENCE   9  (bases 1 to 2714)
  AUTHORS   Feinstein,D.L., Weinmaster,G.A. and Milner,R.J.
  TITLE     Isolation of cDNA clones encoding rat glial fibrillary acidic
            protein: expression in astrocytes and in Schwann cells
  JOURNAL   J Neurosci Res 32 (1), 1-14 (1992)
   PUBMED   1629938
REFERENCE   10 (bases 1 to 2714)
  AUTHORS   Nichols,N.R., Osterburg,H.H., Masters,J.N., Millar,S.L. and
            Finch,C.E.
  TITLE     Messenger RNA for glial fibrillary acidic protein is decreased in
            rat brain following acute and chronic corticosterone treatment
  JOURNAL   Brain Res Mol Brain Res 7 (1), 1-7 (1990)
   PUBMED   2153890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088851.1.
            
            On Oct 12, 2007 this sequence version replaced NM_017009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088851.1, U03700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2714
                     /gene="Gfap"
                     /note="glial fibrillary acidic protein"
                     /db_xref="GeneID:24387"
                     /db_xref="RGD:2679"
     exon            1..456
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1294
                     /gene="Gfap"
                     /note="intermediate filament; glial fibrillary acidic
                     protein alpha; glial fibrillary acidic protein delta"
                     /codon_start=1
                     /product="glial fibrillary acidic protein"
                     /protein_id="NP_058705.2"
                     /db_xref="GeneID:24387"
                     /db_xref="RGD:2679"
                     /translation="MERRRITSARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPL
                     PARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQL
                     RAKEPTKLADVYQAELRELRLRLDQLTTNSARLEVERDNLTQDLGTLRQKLQDETNLR
                     LEAENNLAVYRQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQV
                     HVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQA
                     KHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQ
                     SLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSL
                     DTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM"
     misc_feature    2..211
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Head"
     misc_feature    2..94
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    11..193
                     /gene="Gfap"
                     /note="Intermediate filament head (DNA binding) region;
                     Region: Filament_head; pfam04732"
                     /db_xref="CDD:461414"
     misc_feature    11..193
                     /gene="Gfap"
                     /note="Intermediate filament head (DNA binding) region;
                     Region: Filament_head; pfam04732"
                     /db_xref="CDD:461414"
     misc_feature    20..22
                     /gene="Gfap"
                     /note="Phosphothreonine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    32..34
                     /gene="Gfap"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P03995; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); methylation site"
     misc_feature    35..37
                     /gene="Gfap"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    62..64
                     /gene="Gfap"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P03995; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); methylation site"
     misc_feature    107..109
                     /gene="Gfap"
                     /note="Phosphoserine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    122..124
                     /gene="Gfap"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P03995; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    197..1123
                     /gene="Gfap"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    197..1123
                     /gene="Gfap"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    212..307
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Coil 1A"
     misc_feature    239..241
                     /gene="Gfap"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    308..340
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Linker 1"
     misc_feature    323..325
                     /gene="Gfap"
                     /note="Phosphothreonine. /evidence=ECO:0000269|Ref.9;
                     propagated from UniProtKB/Swiss-Prot (P47819.2);
                     phosphorylation site"
     misc_feature    341..637
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Coil 1B"
     misc_feature    443..445
                     /gene="Gfap"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    638..685
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Linker 12"
     misc_feature    686..751
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Coil 2A"
     misc_feature    752..763
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Linker 2"
     misc_feature    764..1126
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Coil 2B"
     misc_feature    800..802
                     /gene="Gfap"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    962..964
                     /gene="Gfap"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     misc_feature    1127..1291
                     /gene="Gfap"
                     /note="propagated from UniProtKB/Swiss-Prot (P47819.2);
                     Region: Tail"
     misc_feature    1142..1144
                     /gene="Gfap"
                     /note="Phosphothreonine. /evidence=ECO:0000269|Ref.9;
                     propagated from UniProtKB/Swiss-Prot (P47819.2);
                     phosphorylation site"
     misc_feature    1148..1150
                     /gene="Gfap"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
     exon            457..517
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            518..613
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            614..775
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            776..901
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1122
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1166
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1252
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..2688
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggagcgg agacgtatca cctctgcacg ccgctcctat gcctcctccg agacgatggt
       61 caggggccat ggtcctacca gacacctggg taccattccg cgcctctccc tgtctcgaat
      121 gacgcctcca ctccctgcca gggtagactt ctccctggcc ggggcgctca atgccggctt
      181 caaagagact cgggccagcg agcgtgcgga gatgatggag ctcaatgacc gctttgctag
      241 ctacatcgag aaggtccgct tcctggaaca gcaaaacaag gcgctggcag ctgagctgaa
      301 ccagcttcga gccaaggagc ccaccaaact ggctgacgtt taccaggcag aacttcggga
      361 gctgcggctg cgtctggacc agcttactac caacagtgcc cggctggagg tggagaggga
      421 caatctcaca caggacctcg gcaccctgag gcagaagctc caagatgaaa ccaacctgag
      481 gctggaggcg gagaacaacc tggctgtgta cagacaggag gcggatgaag ccaccttggc
      541 tcgtgtggat ctggagagga aggttgagtc gctggaggag gagatccagt tcttgaggaa
      601 gatccatgag gaggaagttc gagaactcca ggagcagctg gcccagcagc aggtccacgt
      661 ggagatggat gtggccaagc cagacctcac agcggctctg agagagattc gcactcagta
      721 cgaggcagtg gccaccagta acatgcaaga aacagaagag tggtatcggt ccaagtttgc
      781 agacctcaca gacgttgctt cccgcaacgc agagctgctc cgccaggcca agcacgaggc
      841 taatgactat cgccgccaac tgcaggcctt gacctgcgac cttgagtcct tgcgcggcac
      901 gaacgagtcc ttggagaggc aaatgcgcga acaggaggag cgccacgcgc gggagtcggc
      961 gagttaccag gaggcactcg ctcggctgga ggaggagggc caaagcctca aggaggagat
     1021 ggcccgccac ctgcaggagt accaggatct actcaacgtt aagctagccc tggacatcga
     1081 gatcgccacc tacaggaaat tgctggaggg cgaagaaaac cgcatcacca ttcctgtaca
     1141 gactttctcc aacctccaga tccgagaaac cagcctggac accaaatctg tgtcagaagg
     1201 ccacctcaag aggaacatcg tggtaaagac ggtggagatg cgggatggcg aggtcattaa
     1261 ggagtcgaag caggagcaca aggatgtgat gtgaggtgtg cccagctggc agcccttgcc
     1321 atacagtgtg agggcctaaa gctccctcct cagatagtct tgtttgctag gcccaattcc
     1381 catccacacc agtgctcccc ttccttctgt ttttatgccc acggctcggt cagtgcggag
     1441 tctcatggac ggcacagacc accctgcatc tccaactaac aggatactca ccccaaaggg
     1501 gcaatcagga ggggaggacc cccctccccc cagctgggtt agaactggaa gaaagaggaa
     1561 agacaggggc agggagactt aacaaatccc ttccttcatc cttgttgtta tggaaaccgt
     1621 tgccagagct ggaggtctct gggaactgga ctttgagttt tcataggctg ctggagcaag
     1681 acaaacattc agacagaaag gaaaagatcc cgaggcaaag aatctctagc cagaggccta
     1741 ggcatctgga agaaccctga cgatgtagga gtgggtaggg cagacttgct acctggaatg
     1801 gccactaagg cagtcctgaa gggcccccct ccggagggat gaccctcgtg tatcggcccc
     1861 actgagcagc cctgcaggtt gatgccccac gagcgtgtga aaacttggtt cttggcatgt
     1921 ggcaggctct atagcataag tggagaggga aggtgtactg gagggtatag aggagggctc
     1981 tctggcccct aagtatggat gcggagaggg gggagcccag gaaggctacc ccgctcaggc
     2041 tgcaggggtg ccatggcgga ggaaccggtg gagataactt ggacaatgga gttggaagtt
     2101 gtaggcaact agttacactt ggctctgaat ccttggaatc aaggaaatga cctgttctct
     2161 caaagacact gaaacaggag agagggactt ccatccactg ggcagggtac aggcgcgtct
     2221 cagttgtgaa ggtctattcc tggttgctca gtccccaact gcgcatcacc ctgggcttct
     2281 caacctggaa gagtccacaa ccatccttct gaggccctcc atccccacaa ccactagctg
     2341 ttgttctcca agccaagggc cccattccct ttcttatgca tgtacggagt atcgcctaga
     2401 ctttaagcgt ccatcctgtt tgaaagtttg ggaaactgac acacgttgtg ttcaagcagc
     2461 ctggtgtgga gtgccttcgt attagtgtac cctctcggaa gctggttggt gggcaggtga
     2521 ggaagaaatg gagctgaaag tgtcccctca gttgtccttt cctccccctc taaggtccct
     2581 cccttttccc aggacatcgt acactccccc ccttgtcacc tctgctaacc ttcagagcag
     2641 tactgtcacc tttactcact gggcagaaat aaagacagtg tcagaggcaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaa
//
LOCUS       NM_001270796            2992 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus phospholipase A2 group VI (Pla2g6), transcript
            variant 2, mRNA.
ACCESSION   NM_001270796
VERSION     NM_001270796.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Kuwata,H., Yuzurihara,C., Kinoshita,N., Taki,Y., Ikegami,Y.,
            Washio,S., Hirakawa,Y., Yoda,E., Aiuchi,T., Itabe,H., Nakatani,Y.
            and Hara,S.
  TITLE     The group VIA calcium-independent phospholipase A2 and NFATc4
            pathway mediates IL-1beta-induced expression of chemokines CCL2 and
            CXCL10 in rat fibroblasts
  JOURNAL   FEBS J 285 (11), 2056-2070 (2018)
   PUBMED   29637744
  REMARK    GeneRIF: the transcriptional activation of nuclear factor of
            activated T-cell proteins (NFATs), but not nuclear factor-kappaB,
            by IL-1beta stimulation was markedly attenuated by the iPLA2
            inhibitor bromoenol lactone, and NFATc4 knockdown markedly
            attenuated the IL-1beta-induced expression of both CCL2 and CXCL10.
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Zhou,Z., Wang,Z., Guan,Q., Qiu,F., Li,Y., Liu,Z., Zhang,H., Dong,H.
            and Zhang,Z.
  TITLE     PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia
            Cardiomyocytes through PEDF Receptor/Phospholipase A2
  JOURNAL   Int J Mol Sci 17 (12), 2064 (2016)
   PUBMED   27973457
  REMARK    GeneRIF: PEDF can protect against hypoxia-induced activation of the
            NLRP3 inflammasome by inhibiting mitochondrial fission though
            PEDFR/iPLA2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Caporarello,N., Salmeri,M., Scalia,M., Motta,C., Parrino,C.,
            Frittitta,L., Olivieri,M., Toscano,M.A., Anfuso,C.D. and Lupo,G.
  TITLE     Role of cytosolic and calcium independent phospholipases A(2) in
            insulin secretion impairment of INS-1E cells infected by S. aureus
  JOURNAL   FEBS Lett 589 (24 Pt B), 3969-3976 (2015)
   PUBMED   26632509
  REMARK    GeneRIF: Data suggest glucose-induced insulin secretion is first
            up-regulated (acute infection), then down-regulated (chronic
            infection) in beta cells infected with S. aureus; Pla2g4a is
            up-regulated in acute infection; Pla2g6 is up-regulated in chronic
            infection.
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Rauckhorst,A.J., Pfeiffer,D.R. and Broekemeier,K.M.
  TITLE     The iPLA(2)gamma is identified as the membrane potential sensitive
            phospholipase in liver mitochondria
  JOURNAL   FEBS Lett 589 (18), 2367-2371 (2015)
   PUBMED   26206229
  REMARK    GeneRIF: membrane potential sensitive activity is the iPLA2gamma
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Takatani-Nakase,T. and Takahashi,K.
  TITLE     Leptin suppresses non-apoptotic cell death in ischemic rat
            cardiomyocytes by reduction of iPLA(2) activity
  JOURNAL   Biochem Biophys Res Commun 463 (1-2), 13-17 (2015)
   PUBMED   25979360
  REMARK    GeneRIF: Leptin was shown to significantly inhibit the activity of
            iPLA2, which is considered to play crucial roles in non-apoptotic
            cell death, resulting in effective prevention of ischemia-induced
            myocyte death.
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   Jenkins,C.M., Han,X., Mancuso,D.J. and Gross,R.W.
  TITLE     Identification of calcium-independent phospholipase A2 (iPLA2)
            beta, and not iPLA2gamma, as the mediator of arginine
            vasopressin-induced arachidonic acid release in A-10 smooth muscle
            cells. Enantioselective mechanism-based discrimination of mammalian
            iPLA2s
  JOURNAL   J Biol Chem 277 (36), 32807-32814 (2002)
   PUBMED   12089145
  REMARK    GeneRIF: The agonist-stimulated release of arachidonic acid (AA)
            from cellular phospholipids in many cell types (e.g. myocytes,
            beta-cells, and neurons) has been demonstrated to be primarily
            mediated by calcium-independent phospholipases A(2) (iPLA(2)s).
REFERENCE   7  (bases 1 to 2992)
  AUTHORS   Seegers,H.C., Gross,R.W. and Boyle,W.A.
  TITLE     Calcium-independent phospholipase A(2)-derived arachidonic acid is
            essential for endothelium-dependent relaxation by acetylcholine
  JOURNAL   J Pharmacol Exp Ther 302 (3), 918-923 (2002)
   PUBMED   12183647
REFERENCE   8  (bases 1 to 2992)
  AUTHORS   Bloch-Shilderman,E., Abu-Raya,S., Trembovler,V., Boschwitz,H.,
            Gruzman,A., Linial,M. and Lazarovici,P.
  TITLE     Pardaxin stimulation of phospholipases A2 and their involvement in
            exocytosis in PC-12 cells
  JOURNAL   J Pharmacol Exp Ther 301 (3), 953-962 (2002)
   PUBMED   12023524
REFERENCE   9  (bases 1 to 2992)
  AUTHORS   Ma,Z., Ramanadham,S., Wohltmann,M., Bohrer,A., Hsu,F.F. and Turk,J.
  TITLE     Studies of insulin secretory responses and of arachidonic acid
            incorporation into phospholipids of stably transfected insulinoma
            cells that overexpress group VIA phospholipase A2 (iPLA2beta)
            indicate a signaling rather than a housekeeping role for iPLA2beta
  JOURNAL   J Biol Chem 276 (16), 13198-13208 (2001)
   PUBMED   11278673
REFERENCE   10 (bases 1 to 2992)
  AUTHORS   Ma,Z., Ramanadham,S., Kempe,K., Chi,X.S., Ladenson,J. and Turk,J.
  TITLE     Pancreatic islets express a Ca2+-independent phospholipase A2
            enzyme that contains a repeated structural motif homologous to the
            integral membrane protein binding domain of ankyrin
  JOURNAL   J Biol Chem 272 (17), 11118-11127 (1997)
   PUBMED   9111008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and BC081916.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061866.1, SRR26643429.28019.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000007.1  112771438-112771496 c
            60-131              JAXUCZ010000007.1  112770999-112771070 c
            132-1358            BC081916.1         53-1279
            1359-2992           BC081916.1         1445-3078
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2992
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="phospholipase A2 group VI"
                     /db_xref="GeneID:360426"
                     /db_xref="RGD:628867"
     exon            1..59
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            60..131
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    95..97
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="upstream in-frame stop codon"
     exon            132..381
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2431
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2; 85
                     kDa calcium-independent phospholipase A2; patatin-like
                     phospholipase domain-containing protein 9; intracellular
                     membrane-associated calcium-independent phospholipase A2
                     beta; 85/88 kDa calcium-independent phospholipase A2;
                     phospholipase A2, group VI (cytosolic,
                     calcium-independent); palmitoyl-CoA hydrolase;
                     2-lysophosphatidylcholine acylhydrolase"
                     /codon_start=1
                     /product="85/88 kDa calcium-independent phospholipase A2
                     isoform 2"
                     /protein_id="NP_001257725.1"
                     /db_xref="GeneID:360426"
                     /db_xref="RGD:628867"
                     /translation="MQFFGRLVNTLSSVTNLFSNPFRVKEVSLADYASSERVREEGQL
                     ILLQNASNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQYSSQLPPFYESSVQVL
                     HVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLAC
                     RKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNN
                     QGLTPLHLACQMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDS
                     NQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSASGNTALHVAVTRNRFDCVM
                     VLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIASK
                     ISKQLQDLMPVSRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKAS
                     GVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEE
                     FLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLK
                     PPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRK
                     GQGNKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCT
                     DPDGRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHRE
                     EFQKLVQLLLSP"
     misc_feature    476..1348
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    476..1348
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    527..619
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    527..619
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(623..625,629..631,641..646,653..661,665..670,
                     680..682,689..691,719..721,725..727,731..733,743..748,
                     755..763,767..772,782..784,791..793,821..823,827..829,
                     833..835,845..850,857..865,869..874,884..886,893..895)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(623..625,629..631,641..646,653..661,665..670,
                     680..682,689..691,719..721,725..727,731..733,743..748,
                     755..763,767..772,782..784,791..793,821..823,827..829,
                     833..835,845..850,857..865,869..874,884..886,893..895)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    623..721
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    623..721
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    725..823
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    725..823
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    827..916
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    827..916
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(1028..1030,1034..1036,1046..1051,1055..1057,
                     1061..1066,1076..1078,1085..1087,1112..1114,1118..1120,
                     1124..1126,1136..1141,1148..1156,1160..1165,1175..1177,
                     1184..1186,1211..1213,1217..1219,1223..1225,1235..1240,
                     1247..1255,1259..1264,1274..1276,1283..1285,1310..1312)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1028..1030,1034..1036,1046..1051,1055..1057,
                     1061..1066,1076..1078,1085..1087,1112..1114,1118..1120,
                     1124..1126,1136..1141,1148..1156,1160..1165,1175..1177,
                     1184..1186,1211..1213,1217..1219,1223..1225,1235..1240,
                     1247..1255,1259..1264,1274..1276,1283..1285,1310..1312)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1028..1114
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1028..1114
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1118..1213
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1118..1213
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1217..1312
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1217..1312
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1448..2389
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Patatin-like phospholipase domain containing
                     protein 9; Region: Pat_PNPLA9; cd07212"
                     /db_xref="CDD:132851"
     misc_feature    1448..2389
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Patatin-like phospholipase domain containing
                     protein 9; Region: Pat_PNPLA9; cd07212"
                     /db_xref="CDD:132851"
     misc_feature    order(1466..1471,1475..1477,1565..1567,1964..1966)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="active site"
                     /db_xref="CDD:132851"
     misc_feature    order(1466..1471,1475..1477,1565..1567,1964..1966)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="active site"
                     /db_xref="CDD:132851"
     misc_feature    1559..1573
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132851"
     misc_feature    1559..1573
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132851"
     exon            382..597
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            598..781
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            782..969
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1066
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1249
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1358
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1437
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1601
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1752
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1889
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2044
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2212
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2286
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2991
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttggatg tcgtcacctg gaccctgctt aggaccgccc tcgtgtccgc gactctgagc
       61 gtccagtcct gggttcacct ctagctccca cagatgacct ggaagctggt ggcagggagc
      121 ctgtgaccca gagcacaggg gcaggctggg tcgcctacct gtcccacata ggatgcagtt
      181 ctttggacgc ctcgttaaca ccctcagtag tgtcaccaac ttgttctcaa acccattccg
      241 ggtaaaggag gtgtccttgg ctgactatgc ctcaagtgaa cgtgttcgag aggaagggca
      301 gctgatcctg ttgcagaatg cttccaatcg tacctgggac tgtgtcctgg tcagccctag
      361 gaacccacag agtggcttcc gactcttcca actggagtca gaggcagacg ccctggtgaa
      421 cttccagcag tattcctccc agctgccacc gttctatgag agctctgtgc aggtcctgca
      481 tgtggaggtg ctgcagcacc tgacggacct cattcggaac caccccagct ggacagtgac
      541 gcacctggcc gtggaacttg gcattcggga gtgtttccat cacagccgca tcatcagctg
      601 cgccaacagc acagagaatg aggagggctg taccccacta catctggcct gccgcaaggg
      661 tgacagtgag attctggtgg agttggtaca gtactgccac gcccagatgg atgtcactga
      721 caacaaagga gagaccgcct tccattatgc tgtgcaaggg gacaatcccc aggtgctaca
      781 gctcctagga aagaatgcct cagccggcct gaaccaggtg aacaaccaag ggctgacgcc
      841 gctgcacctg gcctgccaga tggggaagca ggagatggtg cgtgtcctgc tgctctgcaa
      901 tgcccgctgc aacatcatgg ggcccggtgg cttccccatc cacacagcca tgaagttttc
      961 ccagaagggg tgtgctgaaa tgattatcag catggacagt aaccagatcc acagcaagga
     1021 tcctcgctat ggagccagcc cgctccactg ggccaagaac gctgagatgg cccgaatgct
     1081 tctgaagagg ggctgtgacg tggacagcac aagtgcctcg gggaacacag ccctgcacgt
     1141 ggcggtgacg cgcaaccgct ttgactgtgt catggtgctg ctgacctatg gggccaacgc
     1201 aggtgcccga ggagagcatg ggaacacacc actgcatctg gccatgtcga aagataacat
     1261 ggagatggtc aaagccctca ttgtatttgg ggcagaagta gacaccccga atgactttgg
     1321 ggagactcct gcattcatag cttccaagat cagcaagcag cttcaggacc tcatgcccgt
     1381 ctcccgagcc cggaagccag cgttcatcct gagctccatg agggatgaga agcgaagcca
     1441 tgaccacctg ctctgcttgg atggaggggg cgtgaagggc ctggtcatca tccagcttct
     1501 cattgccatt gagaaggcct caggtgtggc taccaaggac ctcttcgact gggtggcagg
     1561 aaccagcaca ggcggcatcc tggccctggc cattctacac agtaaatcca tggcctatat
     1621 gcgtggcgtg tacttccgta tgaaggatga ggtgtttcgg ggctcacggc cctatgagtc
     1681 tgggcccctg gaggagttcc tgaagcgtga gtttggggag cacaccaaga tgacagatgt
     1741 caagaaaccc aaggtgatgc tgacagggac actgtcagac cggcagccag cagagctcca
     1801 cctcttccgg aattacgacg ccccagaggc cgttcgggaa cctcgctgta ccccaaacat
     1861 taacctgaag ccgcccaccc agcctgcaga ccagttagta tggcgggcag cccggagcag
     1921 tggggcagcc ccaacctatt tccggcccaa tggacgcttc ttggatggtg ggctgctggc
     1981 caacaacccc acactggatg ccatgactga aatccatgag tacaatcagg atatgatccg
     2041 caagggccag ggcaacaagg tgaagaaact ctccatagtc gtgtctctgg ggacaggaaa
     2101 gtcccctcaa gtgcctgtaa cctgtgtaga tgtctttcgt cccagcaacc cttgggaact
     2161 ggccaagact gtttttggag ccaaggaact gggcaagatg gtggtggact gttgcacaga
     2221 tccagatggg cgggctgtgg atcgtgcccg ggcctggtgt gagatggtcg gtatccagta
     2281 cttcaggctg aacccccagc taggctcaga catcatgctg gacgaggtca gtgatgcagt
     2341 gctggtcaac gccctctggg agaccgaggt ctacatctat gagcaccggg aggagttcca
     2401 gaagcttgtc cagctgctgc tatctccctg agcccggccc tgctggcagg agtgcgccgg
     2461 gccgcctggc acactgcggg ccaggctggc ctgccgctcc atgtccatct gagactaggg
     2521 ctcggagcaa acaggttccc catgaggcac ctctcctgat ccatccgcac tttactactc
     2581 caggctgaaa gcccagagtt ccctcggccc cttcccctga ctatgaagga caactgattc
     2641 catctactac cccatatatc agagatcaac actaaggggc cagtgtgccc agagggccct
     2701 cccaggctcc ctggccactg ctgcccaccc cctctcccac ttcctgatgt cagggattag
     2761 agaaatgggg ttccaccccg tcatcaggtg aaatccaggc taatgaaacc cagcgccatt
     2821 ccgccattcg actttgcccc tcgcacctgc agcctctcca ccctgcagcc gccccacaag
     2881 gagcgctcct agctcccaaa ggtcaatcct gtgcacatgc tcttctctgg aaggagagtg
     2941 gggaggggct caaggccacc tcaactgtga aataaacggt tttacactca aa
//
LOCUS       NM_017178               1451 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus bone morphogenetic protein 2 (Bmp2), mRNA.
ACCESSION   NM_017178
VERSION     NM_017178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Zheng,Z., Wang,D., Zhang,W., Yu,H., Zhang,Y., Feng,T. and Zhong,X.
  TITLE     MiR-20 promotes cartilage repair in knee osteoarthritis rats via
            BMP2/Smad1 signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 256-261 (2023)
   PUBMED   38063098
  REMARK    GeneRIF: MiR-20 promotes cartilage repair in knee osteoarthritis
            rats via BMP2/Smad1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Deng,J., Zhao,H.J., Zhong,Y., Hu,C., Meng,J., Wang,C., Lan,X.,
            Wang,X., Chen,Z.J., Yan,J., Wang,W. and Li,Y.
  TITLE     H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement
            compensates for shallow trophoblast invasion in preeclampsia
  JOURNAL   EBioMedicine 93, 104664 (2023)
   PUBMED   37331163
  REMARK    GeneRIF: H3K27me3-modulated Hofbauer cell BMP2 signalling
            enhancement compensates for shallow trophoblast invasion in
            preeclampsia.
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Wang,M., Qiu,Y., Gao,L., Qi,F. and Bi,L.
  TITLE     The impact of IGF-1 on alveolar bone remodeling and BMP-2
            expression in orthodontic tooth movement in diabetic rats
  JOURNAL   Adv Clin Exp Med 32 (3), 349-356 (2023)
   PUBMED   36421043
  REMARK    GeneRIF: The impact of IGF-1 on alveolar bone remodeling and BMP-2
            expression in orthodontic tooth movement in diabetic rats.
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Manzano-Lista,F.J., Sanz-Gomez,M., Gonzalez-Moreno,D.,
            Vega-Martin,E., Gil-Ortega,M., Schulz,A., Rubio,M.A.,
            Ruiz-Hurtado,G., Ruilope,L.M., Aranguez,I., Kreutz,R. and
            Fernandez-Alfonso,M.S.
  TITLE     Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with
            Renal and Cardiovascular Damage in Chronic Kidney Disease
  JOURNAL   Int J Mol Sci 24 (1), 40 (2022)
   PUBMED   36613483
  REMARK    GeneRIF: Imbalance in Bone Morphogenic Proteins 2 and 7 Is
            Associated with Renal and Cardiovascular Damage in Chronic Kidney
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Howard,M.T., Wang,S., Berger,A.G., Martin,J.R.,
            Jalili-Firoozinezhad,S., Padera,R.F. and Hammond,P.T.
  TITLE     Sustained release of BMP-2 using self-assembled layer-by-layer
            film-coated implants enhances bone regeneration over burst release
  JOURNAL   Biomaterials 288, 121721 (2022)
   PUBMED   35981926
  REMARK    GeneRIF: Sustained release of BMP-2 using self-assembled
            layer-by-layer film-coated implants enhances bone regeneration over
            burst release.
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Begue-Kirn,C., Smith,A.J., Loriot,M., Kupferle,C., Ruch,J.V. and
            Lesot,H.
  TITLE     Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin,
            osteonectin and bone sialoprotein gene expression during normal and
            in vitro-induced odontoblast differentiation
  JOURNAL   Int J Dev Biol 38 (3), 405-420 (1994)
   PUBMED   7848824
REFERENCE   8  (bases 1 to 1451)
  AUTHORS   Ohta,S., Hiraki,Y., Shigeno,C., Suzuki,F., Kasai,R., Ikeda,T.,
            Kohno,H., Lee,K., Kikuchi,H., Konishi,J. et al.
  TITLE     Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase
            expression of the proto-oncogene c-fos in murine osteoblastic
            MC3T3-E1 cells
  JOURNAL   FEBS Lett 314 (3), 356-360 (1992)
   PUBMED   1468569
REFERENCE   9  (bases 1 to 1451)
  AUTHORS   Kaplan,F.S., Tabas,J.A. and Zasloff,M.A.
  TITLE     Fibrodysplasia ossificans progressiva: a clue from the fly?
  JOURNAL   Calcif Tissue Int 47 (2), 117-125 (1990)
   PUBMED   2117991
  REMARK    Review article
REFERENCE   10 (bases 1 to 1451)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_017178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z25868.1, L20678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000003.1  141265524-141265767
            245-594             JAXUCZ010000003.1  141266820-141267169
            595-1451            JAXUCZ010000003.1  141273381-141274237
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1451
                     /gene="Bmp2"
                     /note="bone morphogenetic protein 2"
                     /db_xref="GeneID:29373"
                     /db_xref="RGD:2211"
     exon            1..244
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    240..242
                     /gene="Bmp2"
                     /note="upstream in-frame stop codon"
     exon            245..594
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1436
                     /gene="Bmp2"
                     /note="BMP-2; BMP-2A; bone morphogenetic protein 2A"
                     /codon_start=1
                     /product="bone morphogenetic protein 2 precursor"
                     /protein_id="NP_058874.2"
                     /db_xref="GeneID:29373"
                     /db_xref="RGD:2211"
                     /translation="MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAGASGRPLSRP
                     SDDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAA
                     SRANTVRSFHHEEAIEELPEMSGKTSRRFFFNLSSVPTDEFLTSAELQIFREQMQEAL
                     GNSSFQHRINIYEIIKPATASSKFPVTRLLDTRLVTQNTSQWESFDVTPAVMRWTAQG
                     HTNHGFVVEVAHLEEKPGVSKRHVRISRSLHQDEHSWSQVRPLLVTFGHDGKGHPLHK
                     REKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH
                     LNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCG
                     CR"
     sig_peptide     252..308
                     /gene="Bmp2"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49001.1)"
     misc_feature    402..1046
                     /gene="Bmp2"
                     /note="TGF-beta propeptide; Region: TGFb_propeptide;
                     pfam00688"
                     /db_xref="CDD:459906"
     misc_feature    402..1046
                     /gene="Bmp2"
                     /note="TGF-beta propeptide; Region: TGFb_propeptide;
                     pfam00688"
                     /db_xref="CDD:459906"
     misc_feature    507..509
                     /gene="Bmp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P12644; propagated from
                     UniProtKB/Swiss-Prot (P49001.1); phosphorylation site"
     misc_feature    651..653
                     /gene="Bmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49001.1); glycosylation site"
     misc_feature    735..737
                     /gene="Bmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49001.1); glycosylation site"
     misc_feature    843..845
                     /gene="Bmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49001.1); glycosylation site"
     misc_feature    1056..1124
                     /gene="Bmp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P49001.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     mat_peptide     1092..1433
                     /gene="Bmp2"
                     /product="Bone morphogenetic protein 2.
                     /id=PRO_0000033831"
                     /note="propagated from UniProtKB/Swiss-Prot (P49001.1)"
     misc_feature    1125..1433
                     /gene="Bmp2"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in bone morphogenetic protein 2 (BMP-2) and
                     similar proteins; Region: TGF_beta_BMP2; cd19390"
                     /db_xref="CDD:381660"
     misc_feature    1125..1433
                     /gene="Bmp2"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in bone morphogenetic protein 2 (BMP-2) and
                     similar proteins; Region: TGF_beta_BMP2; cd19390"
                     /db_xref="CDD:381660"
     misc_feature    order(1131..1244,1248..1304,1308..1373,1377..1433)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1131..1244,1248..1304,1308..1373,1377..1433)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1146..1148,1152..1154,1164..1169,1173..1175,
                     1203..1205,1209..1217,1266..1271,1278..1283,1287..1292,
                     1299..1301,1308..1316,1323..1325,1329..1334,1341..1343,
                     1401..1409,1413..1415,1431..1433)
                     /gene="Bmp2"
                     /note="putative homodimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1146..1148,1152..1154,1164..1169,1173..1175,
                     1203..1205,1209..1217,1266..1271,1278..1283,1287..1292,
                     1299..1301,1308..1316,1323..1325,1329..1334,1341..1343,
                     1401..1409,1413..1415,1431..1433)
                     /gene="Bmp2"
                     /note="putative homodimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1164..1169,1173..1175,1182..1184,1188..1199,
                     1344..1346,1353..1361,1377..1385,1389..1391,1395..1400,
                     1404..1409,1416..1418)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 3 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1164..1169,1173..1175,1182..1184,1188..1199,
                     1344..1346,1353..1361,1377..1385,1389..1391,1395..1400,
                     1404..1409,1416..1418)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 3 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1173..1175,1182..1184,1191..1196,1209..1217,
                     1263..1271,1275..1283,1287..1289,1311..1316,1323..1325,
                     1329..1334,1353..1355,1359..1361,1383..1409,1413..1415,
                     1431..1433)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 1 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    order(1173..1175,1182..1184,1191..1196,1209..1217,
                     1263..1271,1275..1283,1287..1289,1311..1316,1323..1325,
                     1329..1334,1353..1355,1359..1361,1383..1409,1413..1415,
                     1431..1433)
                     /gene="Bmp2"
                     /note="polypeptide substrate binding site 1 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381660"
     misc_feature    1257..1259
                     /gene="Bmp2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49001.1); glycosylation site"
     exon            595..1451
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcccggcg gatccagtct tgccgccgcc tccagcccgg tcacctctct gttccttggc
       61 cggctgggcc caccccaaga cacggttccc ttcggggaga acacccggag aaggaggagg
      121 tgaagaaagg caacagaagc ccagtcgctg ctccaggtcc ctcggacaga gctttttcca
      181 tgtggagact ctctcaatgg acgtgccccc tagtgcttct tagacggact gcggtctcct
      241 aaaggtcgac catggtggcc gggacccgct gtcttctagt gttgctgctt ccccaggtcc
      301 tcctgggcgg cgcggccggc ctcattccgg agctgggccg caagaagttc gccggggcat
      361 ccggccgccc cttgtcccgg ccttcggacg acgtcctcag cgagtttgag ttgaggctgc
      421 tcagcatgtt tggcctgaag cagagaccca cccccagcaa ggacgtcgtg gtgcccccct
      481 atatgctcga cctgtaccgc cggcactcgg gccagccagg agcgcccgcc ccagaccacc
      541 ggctggagag ggcagccagc cgcgccaaca ccgtgcgcag cttccatcac gaagaagcca
      601 tcgaggaact tccagaaatg agtgggaaaa cgtcccgacg cttcttcttc aatttaagtt
      661 ctgtccctac tgatgagttt ctcacatctg cggagctcca gatttttcgg gaacaaatgc
      721 aggaagcttt gggaaatagt agtttccagc accgaattaa tatttatgaa attataaagc
      781 ctgccacagc cagctcaaaa tttcctgtga ccagactatt ggacaccagg ttagtgactc
      841 agaacacaag tcagtgggag agctttgatg tcaccccggc tgtgatgcga tggacagcac
      901 agggacacac caaccatggg tttgtggtgg aagtggccca cttagaggag aagccaggtg
      961 tctccaagag acatgtgagg attagcaggt ctttgcacca agatgaacac agctggtctc
     1021 aggtaagacc actgctagtg acttttggcc acgacggaaa aggacatcca ctccacaaac
     1081 gagaaaagcg tcaagccaaa cacaaacagc ggaagcgtct taagtccagc tgcaaaaggc
     1141 accctttgta tgtggacttc agtgatgtgg ggtggaatga ctggatcgtg gcccctccag
     1201 gctatcatgc cttttactgc catggggaat gtccttttcc cctggctgat cacctgaact
     1261 ccaccaacca tgccatagtg cagactctgg taaactctgt gaattccaaa atccctaagg
     1321 catgctgtgt ccccactgag cttagcgcaa tctccatgtt gtacctagat gaaaacgaaa
     1381 aggttgtgct aaaaaactat caggacatgg ttgtggaggg ttgcgggtgt cgctagcaca
     1441 gcaagaacaa a
//
LOCUS       NM_019178               3341 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus toll-like receptor 4 (Tlr4), mRNA.
ACCESSION   NM_019178
VERSION     NM_019178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Tao,X., Hu,Y., Mao,N., Shen,M., Fang,M., Zhang,M., Lou,J., Fang,Y.,
            Guo,X. and Lin,Z.
  TITLE     Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 136, 112372 (2024)
   PUBMED   38850784
  REMARK    GeneRIF: Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB
            pathway.
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Xu,L., Zhang,Y., Yu,J., Huo,W., Xu,J., Yang,H., Zhang,M., Yu,S.,
            Wu,Y. and Wang,M.
  TITLE     miR-708-5p deficiency involves the degeneration of mandibular
            condylar chondrocytes via the TLR4/NF-kappaB pathway
  JOURNAL   Osteoarthritis Cartilage 32 (6), 666-679 (2024)
   PUBMED   38403153
  REMARK    GeneRIF: miR-708-5p deficiency involves the degeneration of
            mandibular condylar chondrocytes via the TLR4/NF-kappaB pathway.
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Cao,W., Zeng,Y., Su,Y., Gong,H., He,J., Liu,Y. and Li,C.
  TITLE     The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3
            pathway in acute lung injury induced by high-altitude hypoxia
  JOURNAL   Immunobiology 229 (3), 152809 (2024)
   PUBMED   38788361
  REMARK    GeneRIF: The involvement of oxidative stress and the
            TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by
            high-altitude hypoxia.
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   de Oliveira,A.A., Elder,E., Spaans,F., Graton,M.E., Quon,A.,
            Kirschenman,R., Wooldridge,A.L., Cooke,C.M. and Davidge,S.T.
  TITLE     Excessive hypercholesterolemia in pregnancy impairs rat uterine
            artery function via activation of Toll-like receptor 4
  JOURNAL   Clin Sci (Lond) 138 (4), 137-151 (2024)
   PUBMED   38299431
  REMARK    GeneRIF: Excessive hypercholesterolemia in pregnancy impairs rat
            uterine artery function via activation of Toll-like receptor 4.
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Khomula,E.V., Araldi,D., Green,P.G. and Levine,J.D.
  TITLE     Sensitization of human and rat nociceptors by low dose morphine is
            toll-like receptor 4-dependent
  JOURNAL   Mol Pain 20, 17448069241227922 (2024)
   PUBMED   38195088
  REMARK    GeneRIF: Sensitization of human and rat nociceptors by low dose
            morphine is toll-like receptor 4-dependent.
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Ohashi,K., Burkart,V., Flohe,S. and Kolb,H.
  TITLE     Cutting edge: heat shock protein 60 is a putative endogenous ligand
            of the toll-like receptor-4 complex
  JOURNAL   J Immunol 164 (2), 558-561 (2000)
   PUBMED   10623794
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Takeuchi,O., Takeda,K., Hoshino,K., Adachi,O., Ogawa,T. and
            Akira,S.
  TITLE     Cellular responses to bacterial cell wall components are mediated
            through MyD88-dependent signaling cascades
  JOURNAL   Int Immunol 12 (1), 113-117 (2000)
   PUBMED   10607756
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Takeuchi,O., Hoshino,K., Kawai,T., Sanjo,H., Takada,H., Ogawa,T.,
            Takeda,K. and Akira,S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Frantz,S., Kobzik,L., Kim,Y.D., Fukazawa,R., Medzhitov,R., Lee,R.T.
            and Kelly,R.A.
  TITLE     Toll4 (TLR4) expression in cardiac myocytes in normal and failing
            myocardium
  JOURNAL   J Clin Invest 104 (3), 271-280 (1999)
   PUBMED   10430608
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Vogel,S.N., Johnson,D., Perera,P.Y., Medvedev,A., Lariviere,L.,
            Qureshi,S.T. and Malo,D.
  TITLE     Cutting edge: functional characterization of the effect of the
            C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for
            a dominant negative mutation
  JOURNAL   J Immunol 162 (10), 5666-5670 (1999)
   PUBMED   10229796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019178.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            22 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ175880.1, AF057025.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000005.1  85161247-85161573
            328-494             JAXUCZ010000005.1  85166812-85166978
            495-3341            JAXUCZ010000005.1  85172036-85174882
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3341
                     /gene="Tlr4"
                     /note="toll-like receptor 4"
                     /db_xref="GeneID:29260"
                     /db_xref="RGD:3870"
     exon            1..327
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tlr4"
                     /note="upstream in-frame stop codon"
     CDS             238..2745
                     /gene="Tlr4"
                     /EC_number="3.2.2.6"
                     /note="toll4"
                     /codon_start=1
                     /product="toll-like receptor 4 precursor"
                     /protein_id="NP_062051.2"
                     /db_xref="GeneID:29260"
                     /db_xref="RGD:3870"
                     /translation="MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNL
                     SKIPHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQ
                     LSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNL
                     IHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQ
                     AQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVM
                     EGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLS
                     IIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYS
                     DFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYL
                     DISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQ
                     ISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPK
                     SLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNST
                     CYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQN
                     EDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFI
                     QSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDN
                     ALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT"
     sig_peptide     238..312
                     /gene="Tlr4"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1)"
     misc_feature    304..>1605
                     /gene="Tlr4"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional; Region: PLN00113"
                     /db_xref="CDD:215061"
     misc_feature    304..>1605
                     /gene="Tlr4"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional; Region: PLN00113"
                     /db_xref="CDD:215061"
     mat_peptide     313..2742
                     /gene="Tlr4"
                     /product="Toll-like receptor 4. /id=PRO_0000034728"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1)"
     misc_feature    337..339
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    364..366
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    397..462
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 1"
     misc_feature    409..471
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    409..471
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    460..462
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    469..534
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 2"
     misc_feature    472..543
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    472..543
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    541..606
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 3"
     misc_feature    544..615
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    544..615
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    613..678
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 4"
     misc_feature    616..687
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    616..687
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    685..750
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 5"
     misc_feature    688..762
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    688..762
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    751..753
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    760..831
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 6"
     misc_feature    763..849
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    763..849
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    847..909
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 7"
     misc_feature    847..849
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    850..915
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    850..915
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    913..978
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 8"
     misc_feature    946..948
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    979..981
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1003..1167
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1003..1167
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1078..1080
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1156..1158
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    <1345..>1971
                     /gene="Tlr4"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <1345..>1971
                     /gene="Tlr4"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1351..1380
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 9"
     misc_feature    1354..1431
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1354..1431
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1429..1497
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 10"
     misc_feature    1432..1500
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1432..1500
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1498..1563
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 11"
     misc_feature    1501..1575
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1501..1575
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1573..1638
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 12"
     misc_feature    1576..1647
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1576..1647
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1645..1710
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 13"
     misc_feature    1648..1722
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1648..1722
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1711..1713
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1720..1785
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 14"
     misc_feature    1720..1722
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1723..1794
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1723..1794
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1792..1857
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 15"
     misc_feature    1795..1866
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1795..1866
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1807..1809
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1864..1929
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     Region: LRR 16"
     misc_feature    1867..1938
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1867..1938
                     /gene="Tlr4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1951..1953
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    1960..1962
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    2101..2103
                     /gene="Tlr4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QX05.1); glycosylation site"
     misc_feature    2152..2214
                     /gene="Tlr4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QX05.1);
                     transmembrane region"
     misc_feature    2251..2676
                     /gene="Tlr4"
                     /note="Toll - interleukin 1 - resistance; Region: TIR;
                     smart00255"
                     /db_xref="CDD:214587"
     misc_feature    2251..2676
                     /gene="Tlr4"
                     /note="Toll - interleukin 1 - resistance; Region: TIR;
                     smart00255"
                     /db_xref="CDD:214587"
     exon            328..494
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
     exon            495..3341
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctaacttc cctcctgaga tgggcttatt aattctagaa caaaaccaaa agtgagaatg
       61 ctaaggttgg cactctcact tcctcttgct ctctagccag tatacctttg aatacaatat
      121 ttacagaggg gcaaccgctg ggagagaagg ggcaggggcc ccagggactc tgccctgcca
      181 ccatttacag ttcgtcatgc tttctcacgg cctccgctgg ttgcagaaaa tgccaggatg
      241 atgcctctct tgcatctggc tgggactctg atcatggcat tgttcctttc ctgcctgaga
      301 ccaggaagct tgaatccctg catagaggta cttcctaata ttacctacca atgcatggat
      361 cagaatctca gcaaaatccc tcatgacatc ccttattcaa ccaagaacct agatctgagc
      421 ttcaaccccc tgaagatctt aagaagctat agcttctcca atttctcaca acttcagtgg
      481 ctggatttat ccaggtgtga aattgagaca attgaagaca aggcatggca tggcttaaac
      541 cagctctcaa ccttggtact gacaggaaac cctatcaaga gtttttcccc aggaagtttt
      601 tctggactaa caaatttaga gaatctggtg gctgtggaga caaaaatgac ctctctagag
      661 ggtttccata ttggacagct tatatcctta aagaaactaa atgtggctca taatcttata
      721 cattccttta agttacctga atatttttct aatctgacaa acctagaaca tgtggatctt
      781 tcttataact atattcaaac tatttctgtc aaagacttac agtttctacg tgaaaatccc
      841 caagtcaatc tctctttaga cctgtcttta aacccaattg actccattca agcccaagcc
      901 tttcagggaa ttaggctcca tgaattgact ctaagaagta attttaatag ctcaaatgta
      961 ctgaaaatgt gccttcaaaa catgactggt ttacatgtcc atcggttgat cttgggagaa
     1021 tttaaaaatg aaaggaatct ggaaagtttt gaccgttctg tcatggaagg actatgcaat
     1081 gtgagcattg atgagttcag gttaacatat ataaatcatt tttcagatga tatttataat
     1141 ctcaattgct tggcaaatat ttctgcaatg tctttcacag gtgtacatat aaaacacata
     1201 gcagatgttc ctagacattt caaatggcaa tccttatcaa tcattagatg tcatcttaag
     1261 ccttttccaa agctgagtct accttttctt aaaagttgga ctttaactac caacagagag
     1321 gatatcagct ttggtcagtt ggctctgcca agtctcagat atctagatct tagtagaaat
     1381 gccatgagct ttagaggttg ctgttcttat tctgattttg gaacaaacaa cctgaagtac
     1441 ttagacctca gcttcaatgg tgtcatcctg atgagtgcca acttcatggg tctagaagag
     1501 ctggaatacc tggactttca gcactccact ttaaaaaagg tcacagaatt ctcagtgttc
     1561 ttatctcttg aaaaacttct ttaccttgac atctcttaca ctaataccaa aattgacttt
     1621 gatggcatat ttcttggctt gatcagtctc aacactttaa aaatggctgg caattctttc
     1681 aaagacaaca ccctttcaaa tgtctttaca aacacaacaa acttaacatt cctggatctt
     1741 tctaaatgcc aactggaaca gatatctagg ggggtatttg acacactcta cagactccag
     1801 ttattaaaca tgagtcacaa caacctactg tttctggatc catcccatta taaacagctg
     1861 tactccctca ggactcttga ttgcagtttc aatcgcatag agacatccaa aggaatactg
     1921 caacattttc caaagagtct agccgtcttc aatctgacta ataattctgt tgcttgtata
     1981 tgtgaatatc agaatttctt gcagtgggtc aaggaccaga aaatgttctt ggtgaatgtt
     2041 gaacaaatga aatgtgcatc acctatagac atgaaggcct ccctggtgtt ggattttacg
     2101 aattccacct gttatatata caagactatc atcagtgtat cggtggtcag tgtgcttgtg
     2161 gtagccactg tagcatttct gatataccac ttctattttc acctgatact tattgctggc
     2221 tgtaaaaagt acagcagagg agaaagcatc tatgatgcat ttgtgatcta ctcgagccag
     2281 aatgaggact gggtgagaaa cgagctggta aagaatttag aagaaggagt gccccgcttt
     2341 cagctttgcc ttcattacag ggactttatt cctggtgtag ccattgctgc caacatcatc
     2401 caggaaggct tccacaagag ccggaaagtt attgtggtgg tgtctagaca ctttatccag
     2461 agccgttggt gtatctttga atatgagatt gctcagacat ggcagtttct gagtagccgc
     2521 tctggcatca tcttcattgt ccttgagaaa gtggagaagt ccttgctgag gcagcaggtc
     2581 gaattgtatc gccttcttag cagaaacacc tacctcgagt gggaggacaa tgctctgggg
     2641 aggcacatct tctggagaag actcaaaaaa gccctgttgg atggaaaagc cttgaatcca
     2701 gatgaaacat cagaggaaga acaagaagca acaactttga cctgaggagt acaaaactct
     2761 gcgcctaaaa cccattatgt ttacaatttc cgaatgctac agttcatctg ggtttctgct
     2821 gtggacaggg agtccaggga gcacgaggct tctaacctca acgacctcac agggcacaag
     2881 gaagtagcaa tgtgatgaaa ccccatactt tccatgtgta tcaggtgtat gaattaagca
     2941 actcaggcaa agaatcataa tcagcaaagt ttactcttat aaaacctaag gagaggaggc
     3001 taaggcccag tgagaacaga aaggaacatc attcttctct ggatctttga atataagcac
     3061 aacatgtagt gtgctgcagt taccttagaa gagttttgat catttaaact gaagtgaatg
     3121 tttccttcct ttcccttttt ctattgaata taatttaaat ggcactgact ctttttgaga
     3181 gaccctcatt caaatttctt cttccatttt ctgtcagttt ctttttttaa atctagttct
     3241 acaagaaata tgactgatac atgctcaaag atatcctggt caatccttag aatgctatat
     3301 ttataaaata aaaaatttta gtgtactttt attttttaaa a
//
LOCUS       NM_001278483            5635 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus RUNX family transcription factor 2 (Runx2),
            transcript variant 1, mRNA.
ACCESSION   NM_001278483
VERSION     NM_001278483.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5635)
  AUTHORS   Gopinathan,G., Luan,X. and Diekwisch,T.G.H.
  TITLE     Epigenetic Repression of RUNX2 and OSX Promoters Controls the
            Nonmineralized State of the Periodontal Ligament
  JOURNAL   Genes (Basel) 14 (1), 201 (2023)
   PUBMED   36672941
  REMARK    GeneRIF: Epigenetic Repression of RUNX2 and OSX Promoters Controls
            the Nonmineralized State of the Periodontal Ligament.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5635)
  AUTHORS   Ma,Z., Wang,Y., Xue,Y., Zhang,W., Li,D., Li,Y., Li,G., Zhou,H.,
            Hu,X., Deng,T. and Hu,K.
  TITLE     Traumatic temporomandibular joint bony ankylosis in growing rats
  JOURNAL   BMC Oral Health 22 (1), 585 (2022)
   PUBMED   36494653
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5635)
  AUTHORS   Xie,S., Chen,M., Fang,W., Liu,S., Wu,Q., Liu,C., Xing,Y., Shi,W.,
            Xu,M., Zhang,M., Chen,S., Zeng,X., Wang,S., Deng,W. and Tang,Q.
  TITLE     Diminished arachidonate 5-lipoxygenase perturbs phase separation
            and transcriptional response of Runx2 to reverse pathological
            ventricular remodeling
  JOURNAL   EBioMedicine 86, 104359 (2022)
   PUBMED   36395739
  REMARK    GeneRIF: Diminished arachidonate 5-lipoxygenase perturbs phase
            separation and transcriptional response of Runx2 to reverse
            pathological ventricular remodeling.
REFERENCE   4  (bases 1 to 5635)
  AUTHORS   Zhou,W., Feng,Q., Cheng,M., Zhang,D., Jin,J., Zhang,S., Bai,Y. and
            Xu,J.
  TITLE     LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2
  JOURNAL   Cell Signal 91, 110220 (2022)
   PUBMED   34923106
  REMARK    GeneRIF: LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2.
REFERENCE   5  (bases 1 to 5635)
  AUTHORS   Wang,G., Wang,Z., Gao,S., Wang,Y. and Li,Q.
  TITLE     Curcumin enhances the proliferation and myelinization of Schwann
            cells through Runx2 to repair sciatic nerve injury
  JOURNAL   Neurosci Lett 770, 136391 (2022)
   PUBMED   34902518
REFERENCE   6  (bases 1 to 5635)
  AUTHORS   Xiao,Z.S., Thomas,R., Hinson,T.K. and Quarles,L.D.
  TITLE     Genomic structure and isoform expression of the mouse, rat and
            human Cbfa1/Osf2 transcription factor
  JOURNAL   Gene 214 (1-2), 187-197 (1998)
   PUBMED   9651525
REFERENCE   7  (bases 1 to 5635)
  AUTHORS   Thirunavukkarasu,K., Mahajan,M., McLarren,K.W., Stifani,S. and
            Karsenty,G.
  TITLE     Two domains unique to osteoblast-specific transcription factor
            Osf2/Cbfa1 contribute to its transactivation function and its
            inability to heterodimerize with Cbfbeta
  JOURNAL   Mol Cell Biol 18 (7), 4197-4208 (1998)
   PUBMED   9632804
REFERENCE   8  (bases 1 to 5635)
  AUTHORS   Mundlos,S., Otto,F., Mundlos,C., Mulliken,J.B., Aylsworth,A.S.,
            Albright,S., Lindhout,D., Cole,W.G., Henn,W., Knoll,J.H.,
            Owen,M.J., Mertelsmann,R., Zabel,B.U. and Olsen,B.R.
  TITLE     Mutations involving the transcription factor CBFA1 cause
            cleidocranial dysplasia
  JOURNAL   Cell 89 (5), 773-779 (1997)
   PUBMED   9182765
REFERENCE   9  (bases 1 to 5635)
  AUTHORS   Ducy,P., Zhang,R., Geoffroy,V., Ridall,A.L. and Karsenty,G.
  TITLE     Osf2/Cbfa1: a transcriptional activator of osteoblast
            differentiation
  JOURNAL   Cell 89 (5), 747-754 (1997)
   PUBMED   9182762
REFERENCE   10 (bases 1 to 5635)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 29, 2022 this sequence version replaced NM_001278483.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.49330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:9632804)
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000009.1  23665058-23665199
            143-266             JAXUCZ010000009.1  23665397-23665520
            267-655             JAXUCZ010000009.1  23743281-23743669
            656-812             JAXUCZ010000009.1  23753580-23753736
            813-917             JAXUCZ010000009.1  23760516-23760620
            918-1091            JAXUCZ010000009.1  23818195-23818368
            1092-1253           JAXUCZ010000009.1  23837869-23838030
            1254-1319           JAXUCZ010000009.1  23867080-23867145
            1320-5635           JAXUCZ010000009.1  23868867-23873182
FEATURES             Location/Qualifiers
     source          1..5635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5635
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="RUNX family transcription factor 2"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
     exon            1..142
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2..4
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="upstream in-frame stop codon"
     misc_feature    5..7
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MLHSPHKQPQNHKCGANFLQEDSKEALVFKWLISAGHYQPPRPTESFKAASSIYNRGH
                     KFYLEKKGGT"
     exon            143..266
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1798
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     core-binding factor subunit alpha-1; osteoblast-specific
                     transcription factor 2; runt-related transcription factor
                     2"
                     /codon_start=1
                     /product="runt-related transcription factor 2 isoform 1"
                     /protein_id="NP_001265412.1"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
                     /translation="MASNSLFSAVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSP
                     VVAAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLR
                     PPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGT
                     VVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQV
                     ATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRP
                     SLNSAPSPFNPQGQSQITDPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRG
                     TGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPGISSLTE
                     SRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSST
                     PYLYYGTSSASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSH
                     SSSPTVLNSSGRMDESVWRPY"
     misc_feature    536..922
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    536..922
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    <1028..1675
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1028..1675
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1520..1795
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     misc_feature    1520..1795
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     exon            267..655
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..812
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..917
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1091
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1253
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1319
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..5635
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaatgctt cattcgcctc acaaacaacc acagaaccac aagtgcggtg caaactttct
       61 ccaggaggac agcaaggagg ccctggtgtt taaatggtta atctctgcag gtcactacca
      121 gccaccgaga ccaaccgagt catttaaggc tgcaagcagt atttacaaca gagggcacaa
      181 gttctatctg gaaaaaaaag gagggactat ggcgtcaaac agcctcttca gtgcagtgac
      241 accgtgtcag caaaacttct tttgggatcc gagcaccagc cggcgcttca gccccccctc
      301 cagcagcctg cagcccggca agatgagcga cgtgagcccg gtagtggctg ctcagcagca
      361 gcagcagcag cagcagcagc agcagcagca gcaacagcag caacagcagc agcagcagca
      421 gcaacagcag cagcagcagc agcaggaggc ggccgcagca gcagcagcgg cagcggcggc
      481 ggcagcagcg gcggcagccg tgccccggtt gaggccgccg cacgacaacc gcaccatggt
      541 ggagatcatc gcggaccacc cggccgaact ggtccgcacc gacagcccca acttcctgtg
      601 ctccgtgctg ccctcgcact ggcggtgcaa caagaccctg cccgtggcct tcaaggttgt
      661 agccctcgga gaggtacccg atgggaccgt ggttaccgtc atggccggga atgatgagaa
      721 ctactctgcc gagctacgaa atgcctctgc tgttatgaaa aaccaagtgg ccaggttcaa
      781 cgatctgaga tttgtaggcc ggagcggacg aggcaagagt ttcactttga ccataacggt
      841 cttcacaaat cctccccaag tggccactta ccacagagct attaaagtga cagtggacgg
      901 tccccgggaa ccaagaaggc acagacagaa gcttgatgac tctaaaccta gtttgttctc
      961 tgaccgcctc agtgatttag ggcgcattcc tcatcccagt atgagagtag gtgtcccgcc
     1021 tcagaaccca cggccctccc tgaactcagc accaagtcct tttaatccac aaggacagag
     1081 tcagattaca gatcccaggc agacacaatc ctccccaccg tggtcctatg accagtctta
     1141 cccctcttat ctgagccaga tgacgtcccc atccatccat tccaccacgc cgctgtcttc
     1201 cacacggggc actgggctgc cagccatcac cgacgtaccc aggcgtattt cagatgatga
     1261 cactgccacc tctgacttct gcctctggcc ttcctctctc agtaagaaga gccaggcagg
     1321 tgcttcagaa ctgggccctt tttcagaccc caggcagttc ccaggcattt catccctcac
     1381 tgagagccgc ttctccaacc cacgaatgca ctatccagcc accttcactt acaccccgcc
     1441 agtcacgtca ggcatgtccc tgggcatgtc cgccaccact cactaccaca cgtacctgcc
     1501 accaccctac cccggctctt cccaaagcca gagcggaccc ttccagacca gcagcactcc
     1561 atatctctac tatggtactt cgtcagcgtc ctatcagttc ccaatggtcc ccgggggaga
     1621 ccggtctcct tccaggatgg tcccaccgtg cacgaccacc tcgaatggca gcacgctatt
     1681 aaatccaaat ttgcctaacc agaatgatgg tgttgacgct gatggaagcc acagcagctc
     1741 cccaaccgtt ttgaattcta gcggcagaat ggatgagtct gtctggcgac cctattgaag
     1801 tctgtcaacc gtgcatggcc cagtggcatg cagtggccac gtcccacatg tgttaatata
     1861 tacatatata aagagagtgc ctatatatgt atattgatta gctatctaga agatttctca
     1921 ttcactcccc agttgtgatc tggcaaccct aagagtgtgg ggacagtcat tactgggttt
     1981 catattgttt actatttaag atgtctcctc taccaaggag cagaccgtca aaggtgttat
     2041 ctggtctggt ttcgtaagtg acctgttccc acaacaattc agagaggtgg actctgggtc
     2101 cgggaggaag aacggccact tcctccctgt gctttgcaac caaatcaagg cctctgctgt
     2161 gtggaggcct gtgcactctg cagaccagct tacaaagctg tggtgcactc ggaaagggac
     2221 gagaggcagc gtggctgctt cccctaccgt ccactctgaa tacctgttcc aaagcttccc
     2281 ttcagacttg atgcaggtat gcgtttgaac ttttgagttc actctttttt tttttttttt
     2341 tctattctaa gaaagtgact tcaaaaatac tgatcaggac agattatttt attttacttt
     2401 tttaaaatat tccctcactt cccccattta accaaaaaat aagtcccatt cccctccccc
     2461 gtgcctcctg cttctccctt tatgcaaaac tgaaaatggc aatatcttat tatagccata
     2521 atgatatagt gtttgagttg gctgtgtgtt gtttgttttt actttctttt tttccttttt
     2581 taagttatga atatgtgtaa aatctgaagt aacttgctaa cgtgaatggt catataactt
     2641 taaagatata tttataatta tttaatgaca tttggacatt tggaacattt cttagtgtaa
     2701 tggtctgttg acttcggtct ctaaaagtgc ttcttcttaa ataacaagtt tcttcagtgg
     2761 gctagagcca tatcggaaat attgctaagc aatttcaatt ccttcaggca taatgtgatt
     2821 tttttttttt atgataactc ccatttccaa atattttagt tgtagttttg tttccatgat
     2881 gtatgaagga aatgctatgc ttctttcttt caggtgtttg attgcctctg acacggcttt
     2941 acctgttaaa gcaataatta gggattaaaa aacaaaacaa aacaaaacaa aaaccaccta
     3001 taaccctgca gccctttgac gcttaatgcg gcctctttgc tagcattgaa atgctggaga
     3061 catgtggttt cctaatttct tcatttttgg ggggtggggg gttggccatt atgagtcttg
     3121 tcatattaaa aagccaagca caagtgattg gccgaactgc agaaaagtgt tctgtggtct
     3181 cagagttgag cagaactcta aattgcaggc ttcgtggttg agggcctagg cagctgaaag
     3241 ccacacgtgt agtaaaggct caaccatgac acgtacagcc taggaacaca gatgcattag
     3301 gagtctgcac ccccccccca gccttaccac acagccattc aggggaaccc aaaagtgcct
     3361 tacccaagga gcccccaccc ccaacagcag ctttgcagga agtggaatga agtcaatgtc
     3421 ctaggggagc tggtcagctg aagtagtagc tgatgtcagt agacacagag cctgtgggga
     3481 cctccaggaa gcctttgata ctcaaggctc tcactaggga gggccgtaga gagcagggaa
     3541 gacaatgtat gtagcagttg gtgtctgcca tcgtgtgtga acataagatc cagccctcct
     3601 aggaggacgt actgtgatca ttcctggcac cttgtggcca atccctgagt gtgactccct
     3661 aatccaagcc agagatcatt cagtgacacc accaggcaag tgctagcatt cctcctgcac
     3721 aaagtgtgtt tgttgggggt tggggttggg ggccaccttc ctttgaatcc agagccattc
     3781 taagagtcct tcaggctttt gcctttagcc cctacacccc cttgctctct gttccttctc
     3841 aggttgacct ttgtcccaat gtgggacagt ccaggggcag atggggaact tatgtgtgcc
     3901 tccaacctgt gttttccctc aggattcatc ctgactcctt ctgacacaaa ttgaggggga
     3961 aagaaaccca cccagtagca aaccgaaaca ctttgccttc taaaggttgt gtaccaagta
     4021 tgcacagata gatggtcagg ccacctttgt gtttcttgag atggaatttg tagctgatgc
     4081 tatttattgt ctgtgtgtgg tagcttgaag cacaccacgg tccgtgtgtt tgtctgatgc
     4141 ctatttcagc agcatttaca aaagtcagtg tctggttaca ctttttagtt ttcattaatc
     4201 gacatggaaa tgttaccacc ggtgccagct gcaccctatt taacttcttt tcaaaggcac
     4261 tatatttgta cattattatt tttttcttta acgttaaagg gcttcttaaa gtttacaata
     4321 cagttattaa gggactagag gggatgcctt agtgcccaaa tgttattaca gtggctgcag
     4381 gcagcaaccc agaaacattt ttgaaaacag gttgtttccc tccatcctcc cttatttggg
     4441 aaaaattcaa gtgctttctt cacccttcag ccacctcaca gggtgactcc cgttacaaca
     4501 gtctccccca ttcccccact atgttttaaa ttttcccctt cccctccctt tatctcttaa
     4561 actcttcatt tgcactgggt cacatgtatg atttgtggtt ttaagaccaa agcaatgtct
     4621 taatactctc ctgggactgt tttcgtgtac aaacttccct gggcttagat ggacatggtt
     4681 ctcgaaggag cacaaacatg gctgagattt gcagtgggac cgacacagcc atataaaaaa
     4741 aaatgctctt cagttatctc agaattttaa cctaggccac agttcctaac gggcaccatg
     4801 gctttggttt caggttaggg aatgaggcgc acccagccca taatagaaag acttaccaga
     4861 tttaactagt tggctctcat ccttccctcc gagaccctaa gaaaacgaac agagcaacat
     4921 ctccacatca ttagagactg tccacagtag gttcagaagg gagcagccat gttgggggtt
     4981 ctccttgctc caaggaaagg cactgactga cctagtttta gagaacagta gcgggagcat
     5041 ttgcatccac agtgtttgag agggtaataa acaataaaag atgattctcc cagcctttga
     5101 attcattgtt cttaaagatg atgatgcatc taaaacaaag attttttttt tctcctccta
     5161 tgtgggaact ttcttcgttg tctgtttact tcatgtttac aaataattgt ttgcttttta
     5221 atgcagtact ttaaaaatat atcagccaaa accataacgt acagtaattt cttaggtatt
     5281 ctgaataaaa ttccatgtct ttcgatatgc ctactgttct taggtttctg cggaacaaca
     5341 acaacaacaa caacaaaaaa attgtagcat tttgtgtaaa taacagcttt cgttcttatt
     5401 tttttatttc tctgattgct attgcccaag atttgctttc catgcacata ttgtacaaat
     5461 tctgctttgt accacacagg tcacgattgt ggatgagttt actctgaact tcaaagggac
     5521 tatttgtatt gtatgttgca actgtaaatt gaattatttg gcattttctc ccctcatgat
     5581 tgtaatatta atttgaagtt tgaatttaat tttcaataaa aaggcttttt ttttc
//
LOCUS       NM_057149               2251 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus TNF superfamily member 11 (Tnfsf11), mRNA.
ACCESSION   NM_057149 XM_003751521 XM_006252374
VERSION     NM_057149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Wu,Z., Duan,S., Li,M., Zhang,A., Yang,H., Luo,J., Cheng,R. and
            Hu,T.
  TITLE     Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an
            experimental rat apical periodontitis model
  JOURNAL   Int Endod J 57 (9), 1315-1325 (2024)
   PUBMED   38923421
  REMARK    GeneRIF: Autophagy regulates bone loss via the RANKL/RANK/OPG axis
            in an experimental rat apical periodontitis model.
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Lim,J.H., Kim,H.Y., Kang,H.G., Jeong,H.J. and Kim,H.M.
  TITLE     RANKL down-regulates the mast cell proliferation through inducing
            senescence
  JOURNAL   Cytokine 159, 156018 (2022)
   PUBMED   36054965
  REMARK    GeneRIF: RANKL down-regulates the mast cell proliferation through
            inducing senescence.
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Zhou,J., Guo,L., Yang,Y., Liu,Y. and Zhang,C.
  TITLE     Mechanical force regulates root resorption in rats through RANKL
            and OPG
  JOURNAL   BMC Oral Health 22 (1), 290 (2022)
   PUBMED   35842599
  REMARK    GeneRIF: Mechanical force regulates root resorption in rats through
            RANKL and OPG.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2251)
  AUTHORS   Han,S.Y. and Kim,Y.K.
  TITLE     Yukmijihwang-Tang Suppresses Receptor Activator of Nuclear Factor
            Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation and
            Prevents Ovariectomy (OVX)-Mediated Bone Loss
  JOURNAL   Molecules 26 (24), 7579 (2021)
   PUBMED   34946658
  REMARK    GeneRIF: Yukmijihwang-Tang Suppresses Receptor Activator of Nuclear
            Factor Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation
            and Prevents Ovariectomy (OVX)-Mediated Bone Loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2251)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P., Puzio,I.,
            Kushnir,V., Brezvyn,O., Muzyka,V. and Kotsyumbas,I.
  TITLE     The Influence of Prenatal Fumonisin Exposure on Bone Properties, as
            well as OPG and RANKL Expression and Immunolocalization, in Newborn
            Offspring Is Sex and Dose Dependent
  JOURNAL   Int J Mol Sci 22 (24), 13234 (2021)
   PUBMED   34948030
  REMARK    GeneRIF: The Influence of Prenatal Fumonisin Exposure on Bone
            Properties, as well as OPG and RANKL Expression and
            Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2251)
  AUTHORS   Odgren,P.R., Kim,N., van Wesenbeeck,L., MacKay,C., Mason-Savas,A.,
            Safadi,F.F., Popoff,S.N., Lengner,C., van-Hul,W., Choi,Y. and
            Marks,S.C. Jr.
  TITLE     Evidence that the rat osteopetrotic mutation toothless (tl) is not
            in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene
  JOURNAL   Int J Dev Biol 45 (8), 853-859 (2001)
   PUBMED   11804028
  REMARK    GeneRIF: the toothless (tl) osteopetrotic rat mutation is not in
            the TNFSF11 locus
REFERENCE   7  (bases 1 to 2251)
  AUTHORS   Xu,J., Tan,J.W., Huang,L., Gao,X.H., Laird,R., Liu,D., Wysocki,S.
            and Zheng,M.H.
  TITLE     Cloning, sequencing, and functional characterization of the rat
            homologue of receptor activator of NF-kappaB ligand
  JOURNAL   J Bone Miner Res 15 (11), 2178-2186 (2000)
   PUBMED   11092398
REFERENCE   8  (bases 1 to 2251)
  AUTHORS   Fata,J.E., Kong,Y.Y., Li,J., Sasaki,T., Irie-Sasaki,J.,
            Moorehead,R.A., Elliott,R., Scully,S., Voura,E.B., Lacey,D.L.,
            Boyle,W.J., Khokha,R. and Penninger,J.M.
  TITLE     The osteoclast differentiation factor osteoprotegerin-ligand is
            essential for mammary gland development
  JOURNAL   Cell 103 (1), 41-50 (2000)
   PUBMED   11051546
REFERENCE   9  (bases 1 to 2251)
  AUTHORS   Kong,Y.Y., Yoshida,H., Sarosi,I., Tan,H.L., Timms,E.,
            Capparelli,C., Morony,S., Oliveira-dos-Santos,A.J., Van,G.,
            Itie,A., Khoo,W., Wakeham,A., Dunstan,C.R., Lacey,D.L., Mak,T.W.,
            Boyle,W.J. and Penninger,J.M.
  TITLE     OPGL is a key regulator of osteoclastogenesis, lymphocyte
            development and lymph-node organogenesis
  JOURNAL   Nature 397 (6717), 315-323 (1999)
   PUBMED   9950424
REFERENCE   10 (bases 1 to 2251)
  AUTHORS   Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
            Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
            Galibert,L.
  TITLE     A homologue of the TNF receptor and its ligand enhance T-cell
            growth and dendritic-cell function
  JOURNAL   Nature 390 (6656), 175-179 (1997)
   PUBMED   9367155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_057149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.54384.1,
                                           SRR26643292.54782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680414, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               JAXUCZ010000015.1  60114104-60114479   c
            377-544             JAXUCZ010000015.1  60105734-60105901   c
            545-590             JAXUCZ010000015.1  60090136-60090181   c
            591-689             JAXUCZ010000015.1  60089958-60090056   c
            690-2251            JAXUCZ010000015.1  60083008-60084569   c
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..2251
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="TNF superfamily member 11"
                     /db_xref="GeneID:117516"
                     /db_xref="RGD:620784"
     exon            1..376
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="upstream in-frame stop codon"
     CDS             155..1111
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="osteoprotegerin ligand; osteoclast differentiation
                     factor; TNF-related activation-induced cytokine; receptor
                     activator of nuclear factor kappa-B ligand; tumor necrosis
                     factor (ligand) superfamily, member 11; tumor necrosis
                     factor superfamily member 11"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     11"
                     /protein_id="NP_476490.2"
                     /db_xref="GeneID:117516"
                     /db_xref="RGD:620784"
                     /translation="MRRASRDYGKYLRGSEEMGSCPGVPHEGPLHPAPSAPAPAPPPA
                     ASRFMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTRCFYRILRLRENTGLQD
                     STLESEDTEALPDSCRRMKQAFQGAVQRELQHIVGPQRFSGVPAMMEGSWLDVARRGK
                     PEAQPFAHLTINAANIPSGSHKVSLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLY
                     ANICFRHHETSGSVPADYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSI
                     NVGGFFKLRAGEEISVQVSNPSLLDPDQDATYFGAFKVQDID"
     misc_feature    191..277
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESE2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    296..358
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESE2.1);
                     transmembrane region"
     misc_feature    572..577
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="Cleavage. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9ESE2.1); cleavage site"
     misc_feature    order(656..658,800..802,806..808,983..985,998..1000,
                     1076..1078,1088..1090)
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238108"
     misc_feature    order(656..658,800..802,806..808,983..985,998..1000,
                     1076..1078,1088..1090)
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238108"
     misc_feature    710..1096
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="TNF(Tumour Necrosis Factor) family; Region: TNF;
                     pfam00229"
                     /db_xref="CDD:425540"
     misc_feature    710..1096
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="TNF(Tumour Necrosis Factor) family; Region: TNF;
                     pfam00229"
                     /db_xref="CDD:425540"
     misc_feature    order(719..724,737..739,872..874,893..895,908..910)
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     misc_feature    order(719..724,737..739,872..874,893..895,908..910)
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     misc_feature    749..751
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ESE2.1); glycosylation site"
     misc_feature    944..946
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ESE2.1); glycosylation site"
     exon            377..544
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            545..590
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            591..689
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2251
                     /gene="Tnfsf11"
                     /gene_synonym="ODF; OPGL; RANKL; TRANCE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatctctc ctgagtccca gagagtcact gtctggacct cggtgaaccg gtcggggcgg
       61 gggccgcctg gccgggagtc tgctcggcgg cgggaagccg aggaagggag agagcgatcg
      121 cggagcaggg cgcccgaact ccgggcgccg cgccatgcgc cgggccagcc gagactacgg
      181 caagtacctg cgcggctcgg aggagatggg cagttgccct ggcgtcccac acgagggtcc
      241 gctgcatccc gcgccttcag caccggctcc agcgccgccc cccgccgcct cccgcttcat
      301 gttcctggcg ctcctggggc tgggactggg tcaggtggtc tgcagcatcg ctctgttcct
      361 gtactttcga gcgcagatgg atcctaacag aatatcagaa gacagcacgc gctgcttcta
      421 cagaattctg agactccgtg aaaatacagg tttgcaggac tcgactctgg agagcgaaga
      481 cacagaagca ctacctgact catgcaggag aatgaaacaa gcctttcaag gggccgtgca
      541 aagggaatta caacacattg tggggccaca gcgcttctca ggagttccag ctatgatgga
      601 aggttcgtgg ctcgatgtgg cccggcgggg caagcctgag gctcagccgt ttgctcacct
      661 caccatcaat gctgccaaca tcccatcggg ttcccataaa gtcagtctgt cctcttggta
      721 ccatgatcga ggctgggcca agatctctaa catgacgtta agcaacggaa aactaagggt
      781 taaccaagat ggcttctatt acctgtacgc caacatttgc ttcaggcatc atgaaacctc
      841 agggagcgta cctgcggact atcttcagct gatggtatat gtcgttaaaa ccagcatcaa
      901 aatcccaagt tcgcataacc tgatgaaagg ggggagcact aagaactggt cagggaattc
      961 tgaattccac ttttattcca taaacgttgg aggatttttc aagctccggg ctggtgagga
     1021 aattagcgtc caggtgtcca acccttccct gttggatccg gatcaagatg cgacgtactt
     1081 tggggctttc aaagttcaag acatagactg agacttgttt tgtggagcct tagcatggat
     1141 atgctagatg tttggaaggt tcttaaaaca tggatgatgt agatacatgt gtaagactac
     1201 taagagacgt ggcccacgtt gtacaaaact cacggtcctc tctcgaccct gtacaggtca
     1261 tgtatataca aagtccatag gggatattag actcatggtg atcacacaat ggtttttaca
     1321 attttgaaat gaattcctag aattaaacca aattggaaga ggtataccca tgcttataaa
     1381 aaaaatcgca tgtgagctat ggaagggtca tacatagtct ctgggtctaa ctcctgggcc
     1441 tgtgccactg agaacctcga aattaagagg gtaccgttac attgcagaga aatgatggtt
     1501 tgaaaggtta agttcttttg aattgttaca ttgcgctgga acctgcaaat aagttctttt
     1561 ttctaatgag gagagaaaaa tatatgtatt tttatataat atctaaagtt atatttcagg
     1621 tgtaatgttt tctgtgcaaa atattgtaaa ttatatttgt gctatagtat ttgattcaaa
     1681 atatttaaaa atgtctcact gttgacatat ttaatgtttt aaatgtacag atgtatttaa
     1741 ctggtgcact ttgtaattcc cccccccccc gagggtactt gtagttaagg gggaagaatt
     1801 ctggttctgg tgaccacatg tagtttgttt ctttattctt tttaacttaa tagagttttc
     1861 agacttgtca agcctatgca aacaaaaaaa attaaaatga atatcttgaa taacaagtag
     1921 gatgttggtc accaggtgcc tttcaaattt agaagctaat tgactttagg agctgacata
     1981 gtcaaaaagg attcacaata ggctactgag atctgtcagg agtatttatg taattatcga
     2041 acaggtgtct ttttctacaa gagctacaaa ttgtaaattt tgtttctttc tttctttttt
     2101 tttttaatag aaaaggtact gtggtttatc agccaaaaca caatctactt tttaaatttt
     2161 agtgaaagtt attttattat acctgtacaa taaaagcatt gtctctgaat gttaattttt
     2221 ttggtacaaa aataaatttg tacaaaacct g
//
LOCUS       NM_013063               3571 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase 1 (Parp1), mRNA.
ACCESSION   NM_013063
VERSION     NM_013063.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Wen,J.J., Dejesus,J.E., Radhakrishnan,G.L. and Radhakrishnan,R.S.
  TITLE     PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory
            Response and Cardiac Function
  JOURNAL   J Am Coll Surg 236 (4), 783-802 (2023)
   PUBMED   36728307
  REMARK    GeneRIF: PARP1 Inhibition and Effect on Burn Injury-Induced
            Inflammatory Response and Cardiac Function.
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Chen,Q., Zhang,E., Wang,C., Zhang,P. and Huang,L.
  TITLE     PARP-1 Inhibition Repressed Imbalance of Th17 and Treg Cells in
            Preterm Rats with Intrauterine Infection-Induced Acute Respiratory
            Distress Syndrome by Reducing the Expression Level of IL-6
  JOURNAL   J Healthc Eng 2022, 1255674 (2022)
   PUBMED   35190759
  REMARK    GeneRIF: PARP-1 Inhibition Repressed Imbalance of Th17 and Treg
            Cells in Preterm Rats with Intrauterine Infection-Induced Acute
            Respiratory Distress Syndrome by Reducing the Expression Level of
            IL-6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Wang,L., Wang,P., Xu,S., Li,Z., Duan,D.D., Ye,J., Li,J., Ding,Y.,
            Zhang,W., Lu,J. and Liu,P.
  TITLE     The cross-talk between PARylation and SUMOylation in C/EBPbeta at
            K134 site participates in pathological cardiac hypertrophy
  JOURNAL   Int J Biol Sci 18 (2), 783-799 (2022)
   PUBMED   35002525
  REMARK    GeneRIF: The cross-talk between PARylation and SUMOylation in
            C/EBPbeta at K134 site participates in pathological cardiac
            hypertrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Zhao,R., Jin,X., Li,A., Xu,B., Shen,Y., Wang,W., Huang,J., Zhang,Y.
            and Li,X.
  TITLE     Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent
            Cells via DPP4 Targeting and PARP1 Activation
  JOURNAL   Adv Sci (Weinh) 9 (1), e2104128 (2022)
   PUBMED   34738744
  REMARK    GeneRIF: Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate
            Senescent Cells via DPP4 Targeting and PARP1 Activation.
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Kuchmerovska,T., Guzyk,M., Tykhonenko,T., Yanitska,L.,
            Pryvrotska,I. and Diakun,K.
  TITLE     The parp-1 and bax genes as potential targets for treatment of the
            heart functioning impairments induced by type 1 diabetes mellitus
  JOURNAL   Endocr Regul 55 (2), 61-71 (2021)
   PUBMED   34020532
  REMARK    GeneRIF: The parp-1 and bax genes as potential targets for
            treatment of the heart functioning impairments induced by type 1
            diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Endres,M., Wang,Z.Q., Namura,S., Waeber,C. and Moskowitz,M.A.
  TITLE     Ischemic brain injury is mediated by the activation of
            poly(ADP-ribose)polymerase
  JOURNAL   J Cereb Blood Flow Metab 17 (11), 1143-1151 (1997)
   PUBMED   9390645
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Beneke,S., Meyer,R. and Burkle,A.
  TITLE     Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly
            (ADP-ribose) polymerase
  JOURNAL   Biochem Mol Biol Int 43 (4), 755-761 (1997)
   PUBMED   9385436
  REMARK    Erratum:[Biochem Mol Biol Int 1998 May;44(6):1273]
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Marsischky,G.T., Wilson,B.A. and Collier,R.J.
  TITLE     Role of glutamic acid 988 of human poly-ADP-ribose polymerase in
            polymer formation. Evidence for active site similarities to the
            ADP-ribosylating toxins
  JOURNAL   J Biol Chem 270 (7), 3247-3254 (1995)
   PUBMED   7852410
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Potvin,F., Thibodeau,J., Kirkland,J.B., Dandenault,B., Duchaine,C.
            and Poirier,G.G.
  TITLE     Structural analysis of the putative regulatory region of the rat
            gene encoding poly(ADP-ribose) polymerase
  JOURNAL   FEBS Lett 302 (3), 269-273 (1992)
   PUBMED   1601134
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Thibodeau,J., Gradwohl,G., Dumas,C., Clairoux-Moreau,S., Brunet,G.,
            Penning,C., Poirier,G.G. and Moreau,P.
  TITLE     Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase
            catalytic domain and analysis of mRNA levels during the cell cycle
  JOURNAL   Biochem Cell Biol 67 (9), 653-660 (1989)
   PUBMED   2508731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085765.1.
            
            On Nov 15, 2004 this sequence version replaced NM_013063.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085765.1, U94340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3571
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="poly (ADP-ribose) polymerase 1"
                     /db_xref="GeneID:25591"
                     /db_xref="RGD:2053"
     exon            1..182
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    9..11
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="upstream in-frame stop codon"
     CDS             63..3107
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /EC_number="2.4.2.30"
                     /note="poly[ADP-ribose] synthetase 1; NAD(+)
                     ADP-ribosyltransferase 1; ADPRT 1; DNA
                     ADP-ribosyltransferase PARP1; protein
                     poly-ADP-ribosyltransferase PARP1; poly[ADP-ribose]
                     synthase 1; ADP-ribosyltransferase (NAD+; poly
                     (ADP-ribose) polymerase); poly(ADP-ribose) polymerase
                     PARP-1; poly (ADP-ribose) polymerase family, member 1;
                     ADP-ribosyltransferase diphtheria toxin-like 1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 1"
                     /protein_id="NP_037195.1"
                     /db_xref="GeneID:25591"
                     /db_xref="RGD:2053"
                     /translation="MAEATERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
                     DGKVPHWYHFSCFWKVGHSIRQPDTEVDGFSELRWDDQQKVKKTAEAGGVAGKGQHGG
                     GGKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQMRLSKKMLDPEKPQLGMIDRWYHP
                     TCFVKNRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAVKSEGKRKCDEVDGIDE
                     VAKKKSKKGKDKESSKLEKALKAQNELVWNIKDELKKACSTNDLKELLIFNQQQVPSG
                     ESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEW
                     VTPKEFREISYLKKLKIKKQDRLFPPESSAPAPPAPPVSITSAPTAVNSSAPADKPLS
                     NMKILTLGKLSQNKDEAKAMIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAA
                     NVRVVCEDFLQDVSASAKSLQELLSAHSLSSWGAEVKVEPGEVVVPKGKSAAPSKKSK
                     GAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
                     NSYYKLQLLESDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGN
                     AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLAVKPGTKSKLPKPVQELVGMIFDVESM
                     KKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLI
                     PHDFGMKKPPLLNNTDSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
                     TDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHN
                     RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
                     PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTAPDPSASITLDGVEVPLG
                     TGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
     misc_feature    66..68
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    87..3092
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="poly [ADP-ribose] polymerase; Provisional; Region:
                     PLN03123"
                     /db_xref="CDD:215590"
     misc_feature    87..3092
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="poly [ADP-ribose] polymerase; Provisional; Region:
                     PLN03123"
                     /db_xref="CDD:215590"
     misc_feature    183..185
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    351..353
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    375..377
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    453..455
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    591..593
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    597..599
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    615..617
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    681..689
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P09874"
     misc_feature    702..707
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Cleavage, by caspase-3 and caspase-7.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); cleavage site"
     misc_feature    723..740
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P09874"
     misc_feature    885..887
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    894..896
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    933..1061
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Zinc ribbon.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01351"
     misc_feature    1131..1223
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1182..1634
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Automodification domain.
                     /evidence=ECO:0000250|UniProtKB:P09874"
     misc_feature    1548..1619
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P27008.4);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1842..1844
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    1860..1862
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    1923..1925
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); acetylation site"
     misc_feature    2406..2408
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     misc_feature    2418..2420
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09874; propagated from
                     UniProtKB/Swiss-Prot (P27008.4); phosphorylation site"
     exon            183..348
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..464
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..679
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..782
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..899
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1076
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1224
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1365
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1605
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1674
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1807
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2003
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2132
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2216
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2339
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2468
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2567
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2720
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2848
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2910
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3025
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3536
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacacgtta gcggagcgga ccggcggcgg cgtctgcctg ccgctgcggc acgagaggga
       61 ggatggcgga ggccacggag aggctttacc gagtggagta cgctaagagc gggcgcgcct
      121 cttgcaagaa atgcagcgag agtatcccca aggactcgct ccgcatggcc atcatggtgc
      181 agtcacccat gttcgatgga aaagtcccac actggtatca cttctcctgc ttctggaagg
      241 tgggccactc catccggcag cctgacacag aggtggacgg gttctctgag ctgcggtggg
      301 atgaccagca gaaggtcaag aagaccgcag aggctggagg cgtggcaggc aaaggccagc
      361 atggaggtgg cggcaaggcg gagaagacgc tgggcgactt tgcggcagag tatgccaagt
      421 ccaacaggag cacatgcaag ggctgcatgg agaagataga gaagggtcag atgcgcctgt
      481 ccaagaagat gctggatcca gagaagccgc aactgggtat gattgaccgc tggtaccatc
      541 caacttgctt tgtcaagaac cgggacgagc tgggcttccg gcctgagtac agtgccagcc
      601 agctcaaggg ctttagcctc ctctctgcag aagacaaaga agctctgaag aagcagctcc
      661 cggcagtcaa gagtgaagga aagagaaaat gtgacgaggt ggatggaata gatgaagtag
      721 ccaaaaagaa atctaaaaaa ggaaaggaca aggagagtag taaactggaa aaggcgctca
      781 aggctcagaa cgagctggtc tggaatatca aagatgagct gaagaaagcc tgctccacca
      841 acgacctgaa ggagttgctc atcttcaacc agcagcaagt accatctgga gagtccgcaa
      901 tcctggaccg agttgctgat ggcatggcgt ttggggccct tctgccctgc aaggagtgtt
      961 caggacagct ggtttttaag agcgacgctt attactgtac tggggatgtc actgcctgga
     1021 ccaagtgcat ggtcaagaca cagaatccca gccgaaagga atgggtaact ccaaaggaat
     1081 tccgagaaat atcctacctc aagaaattaa agatcaaaaa gcaggaccgg ctgttccctc
     1141 cagagagcag cgccccagca ccaccagcac ctcccgtctc gatcacctcc gcacccacag
     1201 ctgtgaactc ctctgcacca gcagacaaac ccctgtctaa catgaagatc ctgactcttg
     1261 gtaagctctc ccagaacaag gacgaagcaa aggccatgat tgagaaactc ggaggcaagc
     1321 tgacaggatc tgccaacaag gcctccttgt gtatcagcac taagaaggag gtggagaaga
     1381 tgagtaagaa gatggaggaa gtgaaagcag ccaatgttcg agtcgtgtgt gaggacttcc
     1441 tccaggatgt gtctgcctca gctaagagcc tccaagagct gctctcagcc catagcttgt
     1501 cctcgtgggg ggctgaggtg aaggtagagc ctggtgaagt ggtggtcccc aaggggaagt
     1561 cagctgcacc ctccaagaag agcaagggtg ctgtcaagga ggaaggtgtc aacaagtctg
     1621 aaaagaggat gaaactaact ctgaagggag gagcagccgt tgatcctgac tctggtctgg
     1681 aacactctgc acatgtcctg gagaaaggcg ggaaggtgtt cagtgccacg cttggcctgg
     1741 tggacattgt gaaagggact aactcctatt acaaactgca acttctggag tccgacaagg
     1801 agagcaggta ttggatcttc cggtcctggg gccgagtggg cacagttatc ggcagtaaca
     1861 agcttgagca gatgccgtcc aaagaggatg ctgttgaaca cttcatgaag ttatacgaag
     1921 agaagactgg aaatgcctgg cactcgaaaa acttcacaaa gtatcccaag aagttctacc
     1981 ctctggagat tgactatggc caggacgaag aggcagtaaa gaagctggcg gtgaagcctg
     2041 gcactaagtc gaagctgccg aagccggtgc aggagctcgt cgggatgatc ttcgacgtgg
     2101 agagcatgaa gaaggccttg gtggagtacg agattgacct tcagaagatg cccttgggga
     2161 aactgagcag aaggcagatc caggccgcct actctatcct cagtgaggtc cagcaggcag
     2221 tgtcccaagg cagcagtgaa tctcagatcc tggatctctc caatcgcttc tacaccctca
     2281 tcccccatga ctttggaatg aagaagcccc cacttctgaa caacacagac agtgtgcagg
     2341 ccaaggtgga gatgctggac aacctcctgg acatcgaggt tgcctatagt cttctcaggg
     2401 gtgggtctga tgacagcagt aaggacccca tcgatgtcaa ctatgagaag ctcaaaactg
     2461 acattaaggt ggttgacaga gattctgaag aggctgaggt catcaggaag tatgtgaaga
     2521 acactcacgc gaccacgcac aatgcctatg acctggaagt gatagacatc tttaagatag
     2581 agcgagaggg agagagccaa cgctacaagc ccttcaggca gcttcacaac cggagactgc
     2641 tgtggcacgg gtccaggacc accaacttcg caggcatcct gtcacagggt ctgcggatag
     2701 ccccacctga agcacctgtg acaggctaca tgtttgggaa aggaatctac tttgctgata
     2761 tggtgtccaa aagtgcgaac tactgccaca cgtctcaggg agacccgatt ggcttaatac
     2821 tgttgggaga agttgccctt ggaaacatgt acgaactcaa gcatgcttct cacatcagca
     2881 agttacccaa gggcaagcac agtgtcaaag gtttgggcaa aaccgcccct gacccttcgg
     2941 ccagcatcac cctggatggt gtagaggttc cgctgggaac agggattccg tctggtgtta
     3001 atgacacctg cctgctgtat aacgagtaca ttgtctacga cattgctcag gtgaatctga
     3061 agtacctact gaaactgaag ttcaatttca agacctcctt gtggtagagt gaaggcgggc
     3121 tttgccagca cccggggcct aggggataat gcccctagtg cctctgcacc aaacaccaca
     3181 acacctcagc catgctgccg cctcagggtg gcaccctcac cgaatctcct taggaaggac
     3241 tttacacaga taggttgcgc tggagtggga cggctgtttg tggtttgtcc aaccaggcac
     3301 agccgtgaca gacagctggc agtagaggga aagttgggga gaggtttttg ttgtttgcct
     3361 agactagtcc tgagggaaga aaccgccacg tcacagtcac aatgtctgcc ttactggctt
     3421 ccccagggaa ggaaaatgtg cttcctccct tctttcaagg gttcatcttt ggtttgattt
     3481 tggcaaaatg ttaagcattt attttgagct aaaaaataaa aactaatttc atactaaaaa
     3541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
LOCUS       NM_144744               1487 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus adiponectin, C1Q and collagen domain containing
            (Adipoq), mRNA.
ACCESSION   NM_144744
VERSION     NM_144744.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   Zhou,Y., Zhang,S., Jia,Y., Wang,X., Liu,Y., Zhang,H., Yuan,Z.,
            Han,Y. and Weng,Q.
  TITLE     Regulation and Role of Adiponectin Secretion in Rat Ovarian
            Granulosa Cells
  JOURNAL   Int J Mol Sci 25 (10), 5155 (2024)
   PUBMED   38791193
  REMARK    GeneRIF: Regulation and Role of Adiponectin Secretion in Rat
            Ovarian Granulosa Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1487)
  AUTHORS   Khoramipour,K., Bejeshk,M.A., Rajizadeh,M.A., Najafipour,H.,
            Dehghan,P. and Farahmand,F.
  TITLE     High-Intensity Interval Training Ameliorates Molecular Changes in
            the Hippocampus of Male Rats with the Diabetic Brain: the Role of
            Adiponectin
  JOURNAL   Mol Neurobiol 60 (6), 3486-3495 (2023)
   PUBMED   36877358
  REMARK    GeneRIF: High-Intensity Interval Training Ameliorates Molecular
            Changes in the Hippocampus of Male Rats with the Diabetic Brain:
            the Role of Adiponectin.
REFERENCE   3  (bases 1 to 1487)
  AUTHORS   Cheng,R., Xu,X., Yang,S., Mi,Z., Zhao,Y., Wang,C., Shi,X., Gao,J.,
            Yu,F. and Ren,X.
  TITLE     The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
  JOURNAL   BMC Oral Health 23 (1), 85 (2023)
   PUBMED   36765308
  REMARK    GeneRIF: The effect of APN, hs-CRP and APN/hs-CRP in periodontitis
            with DAA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1487)
  AUTHORS   Marine-Casado,R., Domenech-Coca,C., Crescenti,A., Rodriguez
            Gomez,M.A., Del Bas,J.M., Arola,L., Boque,N. and Caimari,A.
  TITLE     Maternal Supplementation with a Cocoa Extract during Lactation
            Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring
  JOURNAL   Nutrients 14 (23), 5134 (2022)
   PUBMED   36501173
  REMARK    GeneRIF: Maternal Supplementation with a Cocoa Extract during
            Lactation Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1487)
  AUTHORS   Qiao,N., Zhang,J., Zhang,Y. and Liu,X.
  TITLE     Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation
  JOURNAL   Ann Clin Lab Sci 52 (4), 634-641 (2022)
   PUBMED   36197773
  REMARK    GeneRIF: Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation.
REFERENCE   6  (bases 1 to 1487)
  AUTHORS   Yokota,T., Oritani,K., Takahashi,I., Ishikawa,J., Matsuyama,A.,
            Ouchi,N., Kihara,S., Funahashi,T., Tenner,A.J., Tomiyama,Y. and
            Matsuzawa,Y.
  TITLE     Adiponectin, a new member of the family of soluble defense
            collagens, negatively regulates the growth of myelomonocytic
            progenitors and the functions of macrophages
  JOURNAL   Blood 96 (5), 1723-1732 (2000)
   PUBMED   10961870
REFERENCE   7  (bases 1 to 1487)
  AUTHORS   Ouchi,N., Kihara,S., Arita,Y., Maeda,K., Kuriyama,H., Okamoto,Y.,
            Hotta,K., Nishida,M., Takahashi,M., Nakamura,T., Yamashita,S.,
            Funahashi,T. and Matsuzawa,Y.
  TITLE     Novel modulator for endothelial adhesion molecules:
            adipocyte-derived plasma protein adiponectin
  JOURNAL   Circulation 100 (25), 2473-2476 (1999)
   PUBMED   10604883
REFERENCE   8  (bases 1 to 1487)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   9  (bases 1 to 1487)
  AUTHORS   Schaffler,A., Orso,E., Palitzsch,K.D., Buchler,C., Drobnik,W.,
            Furst,A., Scholmerich,J. and Schmitz,G.
  TITLE     The human apM-1, an adipocyte-specific gene linked to the family of
            TNF's and to genes expressed in activated T cells, is mapped to
            chromosome 1q21.3-q23, a susceptibility locus identified for
            familial combined hyperlipidaemia (FCH)
  JOURNAL   Biochem Biophys Res Commun 260 (2), 416-425 (1999)
   PUBMED   10403784
REFERENCE   10 (bases 1 to 1487)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM047633.1 and JAXUCZ010000011.1.
            
            On Mar 23, 2011 this sequence version replaced NM_144744.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078720.1, FM047633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               FM047633.1         1-568
            569-1487            JAXUCZ010000011.1  91226524-91227442   c
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1487
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="adiponectin, C1Q and collagen domain containing"
                     /db_xref="GeneID:246253"
                     /db_xref="RGD:628748"
     exon            1..71
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
     exon            72..299
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..820
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="adipocyte complement related protein of 30 kDa;
                     adiponectin d"
                     /codon_start=1
                     /product="adiponectin precursor"
                     /protein_id="NP_653345.1"
                     /db_xref="GeneID:246253"
                     /db_xref="RGD:628748"
                     /translation="MLLLQALLFLLILPSHEGITATEGPGALVPPPKETCAGWMAGIP
                     GYPGHNGIPGRDGRDGTPGEKGEKGDAGVLGPKGDPGDAGMTGAEGPRGFPGTPGRKG
                     EPGEAAYMYHSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYF
                     SYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSMLLHLEVGDQVWLQVYGE
                     GDNNGLYADNVNDSTFTGFLLYHDTN"
     sig_peptide     86..139
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    236..406
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="Collagen triple helix repeat (20 copies); Region:
                     Collagen; pfam01391"
                     /db_xref="CDD:460189"
     misc_feature    236..406
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="Collagen triple helix repeat (20 copies); Region:
                     Collagen; pfam01391"
                     /db_xref="CDD:460189"
     misc_feature    410..811
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="Complement component C1q domain; Region: C1Q;
                     smart00110"
                     /db_xref="CDD:128420"
     misc_feature    410..811
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="Complement component C1q domain; Region: C1Q;
                     smart00110"
                     /db_xref="CDD:128420"
     exon            300..1487
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaggagac ctggcgattt tctcttcatt cctgtctgta cgagtgccag tggatctgat
       61 tacaccaaaa gttccaggac tcaggatgct actgttgcaa gcgctcctgt tcctcttaat
      121 cctgcccagt catgaaggga ttactgcaac cgaagggcca ggagctttgg tccctccacc
      181 caaggaaact tgtgcaggtt ggatggcagg catcccagga tatcctggtc acaatgggat
      241 accgggccgt gatggcagag atggcactcc tggagagaag ggagagaagg gagacgcagg
      301 tgttcttggt cctaagggtg acccaggaga tgctggaatg acaggagcgg aagggccacg
      361 gggctttccc ggaacccctg gcaggaaagg agagcccgga gaagccgctt acatgtatca
      421 ctcagcattc agcgtagggc tggagacccg cgtcactgtc cccaatgttc ccattcgctt
      481 tactaagatc ttctacaacc aacagaatca ttatgacggc agcactggca aattccactg
      541 caacattccg gggctctact acttttccta ccacatcacg gtgtacatga aggatgtgaa
      601 agtgagcctc ttcaagaagg acaaggccgt tctcttcacc tacgaccagt atcaggaaaa
      661 aaatgtggac caggcctctg gctccatgct cctccatctg gaggtgggag accaagtctg
      721 gctccaagtg tatggggaag gggacaacaa tggactctat gcagataatg tcaatgactc
      781 tacatttaca ggcttccttc tctaccatga taccaactga ctgccactaa ttcagagcag
      841 cccgtagccc cgagaatcaa agaacaggcg acaggctttc agcttagttt gagaggttga
      901 ttgtattgct tactttgagg gttctgagtg ttatccccat gagtactcat ttgttcatta
      961 aatgacttta taaaaaataa tttctgtgtt cctagttgag aaaaaaagca ctccctagtc
     1021 tccgcgcctc tttttttttt tgatcatcaa caactatttt ttattacaac tatattgcca
     1081 ctttgacatt gcagtgtaat tagaggtact caggattatt ttgtctccac agtcttttaa
     1141 ccaaagtttc atatttagtc cttttgtatt ctggttaata cttattatag aattgatatt
     1201 tagccatgtg ggaaaaagta accaatctta agaatcagca tctagccaca tctgtgagat
     1261 agcatcttca gtcaagactg atgtgagaag gcccatctca ctgtgggctg aaccaggacc
     1321 tggacgtaag tgcattgaca gtctaagaaa gcaagctgag tgttcaccag ccagctagcc
     1381 agtaagcagc atttcaccat ggcttctgcg ttagttcctg cctgatttca ctctcgattg
     1441 tctataacct ggaattataa gttgaaataa atccttccct tacctaa
//
LOCUS       NM_001415755            5668 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus RUNX family transcription factor 2 (Runx2),
            transcript variant 3, mRNA.
ACCESSION   NM_001415755
VERSION     NM_001415755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5668)
  AUTHORS   Gopinathan,G., Luan,X. and Diekwisch,T.G.H.
  TITLE     Epigenetic Repression of RUNX2 and OSX Promoters Controls the
            Nonmineralized State of the Periodontal Ligament
  JOURNAL   Genes (Basel) 14 (1), 201 (2023)
   PUBMED   36672941
  REMARK    GeneRIF: Epigenetic Repression of RUNX2 and OSX Promoters Controls
            the Nonmineralized State of the Periodontal Ligament.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5668)
  AUTHORS   Ma,Z., Wang,Y., Xue,Y., Zhang,W., Li,D., Li,Y., Li,G., Zhou,H.,
            Hu,X., Deng,T. and Hu,K.
  TITLE     Traumatic temporomandibular joint bony ankylosis in growing rats
  JOURNAL   BMC Oral Health 22 (1), 585 (2022)
   PUBMED   36494653
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5668)
  AUTHORS   Xie,S., Chen,M., Fang,W., Liu,S., Wu,Q., Liu,C., Xing,Y., Shi,W.,
            Xu,M., Zhang,M., Chen,S., Zeng,X., Wang,S., Deng,W. and Tang,Q.
  TITLE     Diminished arachidonate 5-lipoxygenase perturbs phase separation
            and transcriptional response of Runx2 to reverse pathological
            ventricular remodeling
  JOURNAL   EBioMedicine 86, 104359 (2022)
   PUBMED   36395739
  REMARK    GeneRIF: Diminished arachidonate 5-lipoxygenase perturbs phase
            separation and transcriptional response of Runx2 to reverse
            pathological ventricular remodeling.
REFERENCE   4  (bases 1 to 5668)
  AUTHORS   Zhou,W., Feng,Q., Cheng,M., Zhang,D., Jin,J., Zhang,S., Bai,Y. and
            Xu,J.
  TITLE     LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2
  JOURNAL   Cell Signal 91, 110220 (2022)
   PUBMED   34923106
  REMARK    GeneRIF: LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2.
REFERENCE   5  (bases 1 to 5668)
  AUTHORS   Wang,G., Wang,Z., Gao,S., Wang,Y. and Li,Q.
  TITLE     Curcumin enhances the proliferation and myelinization of Schwann
            cells through Runx2 to repair sciatic nerve injury
  JOURNAL   Neurosci Lett 770, 136391 (2022)
   PUBMED   34902518
REFERENCE   6  (bases 1 to 5668)
  AUTHORS   Xiao,Z.S., Thomas,R., Hinson,T.K. and Quarles,L.D.
  TITLE     Genomic structure and isoform expression of the mouse, rat and
            human Cbfa1/Osf2 transcription factor
  JOURNAL   Gene 214 (1-2), 187-197 (1998)
   PUBMED   9651525
REFERENCE   7  (bases 1 to 5668)
  AUTHORS   Thirunavukkarasu,K., Mahajan,M., McLarren,K.W., Stifani,S. and
            Karsenty,G.
  TITLE     Two domains unique to osteoblast-specific transcription factor
            Osf2/Cbfa1 contribute to its transactivation function and its
            inability to heterodimerize with Cbfbeta
  JOURNAL   Mol Cell Biol 18 (7), 4197-4208 (1998)
   PUBMED   9632804
REFERENCE   8  (bases 1 to 5668)
  AUTHORS   Mundlos,S., Otto,F., Mundlos,C., Mulliken,J.B., Aylsworth,A.S.,
            Albright,S., Lindhout,D., Cole,W.G., Henn,W., Knoll,J.H.,
            Owen,M.J., Mertelsmann,R., Zabel,B.U. and Olsen,B.R.
  TITLE     Mutations involving the transcription factor CBFA1 cause
            cleidocranial dysplasia
  JOURNAL   Cell 89 (5), 773-779 (1997)
   PUBMED   9182765
REFERENCE   9  (bases 1 to 5668)
  AUTHORS   Ducy,P., Zhang,R., Geoffroy,V., Ridall,A.L. and Karsenty,G.
  TITLE     Osf2/Cbfa1: a transcriptional activator of osteoblast
            differentiation
  JOURNAL   Cell 89 (5), 747-754 (1997)
   PUBMED   9182762
REFERENCE   10 (bases 1 to 5668)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.49329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000009.1  23665058-23665232
            176-299             JAXUCZ010000009.1  23665397-23665520
            300-688             JAXUCZ010000009.1  23743281-23743669
            689-845             JAXUCZ010000009.1  23753580-23753736
            846-950             JAXUCZ010000009.1  23760516-23760620
            951-1124            JAXUCZ010000009.1  23818195-23818368
            1125-1286           JAXUCZ010000009.1  23837869-23838030
            1287-1352           JAXUCZ010000009.1  23867080-23867145
            1353-5668           JAXUCZ010000009.1  23868867-23873182
FEATURES             Location/Qualifiers
     source          1..5668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5668
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="RUNX family transcription factor 2"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
     exon            1..175
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2..4
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="upstream in-frame stop codon"
     misc_feature    5..7
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MLHSPHKQPQNHKCGANFLQEDSKEALVFKWLISAGHYQPPRPTESVSALSTVHAVIF
                     KAASSIYNRGHKFYLEKKGGT"
     exon            176..299
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1831
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     core-binding factor subunit alpha-1; osteoblast-specific
                     transcription factor 2; runt-related transcription factor
                     2"
                     /codon_start=1
                     /product="runt-related transcription factor 2 isoform 1"
                     /protein_id="NP_001402684.1"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
                     /translation="MASNSLFSAVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSP
                     VVAAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLR
                     PPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGT
                     VVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQV
                     ATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRP
                     SLNSAPSPFNPQGQSQITDPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRG
                     TGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPGISSLTE
                     SRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSST
                     PYLYYGTSSASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSH
                     SSSPTVLNSSGRMDESVWRPY"
     misc_feature    569..955
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    569..955
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    <1061..1708
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1061..1708
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1553..1828
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     misc_feature    1553..1828
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     exon            300..688
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..845
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..950
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1124
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1286
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1352
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..5668
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaatgctt cattcgcctc acaaacaacc acagaaccac aagtgcggtg caaactttct
       61 ccaggaggac agcaaggagg ccctggtgtt taaatggtta atctctgcag gtcactacca
      121 gccaccgaga ccaaccgagt cagtgagtgc tctgagcaca gtccatgcag taatatttaa
      181 ggctgcaagc agtatttaca acagagggca caagttctat ctggaaaaaa aaggagggac
      241 tatggcgtca aacagcctct tcagtgcagt gacaccgtgt cagcaaaact tcttttggga
      301 tccgagcacc agccggcgct tcagcccccc ctccagcagc ctgcagcccg gcaagatgag
      361 cgacgtgagc ccggtagtgg ctgctcagca gcagcagcag cagcagcagc agcagcagca
      421 gcagcaacag cagcaacagc agcagcagca gcagcaacag cagcagcagc agcagcagga
      481 ggcggccgca gcagcagcag cggcagcggc ggcggcagca gcggcggcag ccgtgccccg
      541 gttgaggccg ccgcacgaca accgcaccat ggtggagatc atcgcggacc acccggccga
      601 actggtccgc accgacagcc ccaacttcct gtgctccgtg ctgccctcgc actggcggtg
      661 caacaagacc ctgcccgtgg ccttcaaggt tgtagccctc ggagaggtac ccgatgggac
      721 cgtggttacc gtcatggccg ggaatgatga gaactactct gccgagctac gaaatgcctc
      781 tgctgttatg aaaaaccaag tggccaggtt caacgatctg agatttgtag gccggagcgg
      841 acgaggcaag agtttcactt tgaccataac ggtcttcaca aatcctcccc aagtggccac
      901 ttaccacaga gctattaaag tgacagtgga cggtccccgg gaaccaagaa ggcacagaca
      961 gaagcttgat gactctaaac ctagtttgtt ctctgaccgc ctcagtgatt tagggcgcat
     1021 tcctcatccc agtatgagag taggtgtccc gcctcagaac ccacggccct ccctgaactc
     1081 agcaccaagt ccttttaatc cacaaggaca gagtcagatt acagatccca ggcagacaca
     1141 atcctcccca ccgtggtcct atgaccagtc ttacccctct tatctgagcc agatgacgtc
     1201 cccatccatc cattccacca cgccgctgtc ttccacacgg ggcactgggc tgccagccat
     1261 caccgacgta cccaggcgta tttcagatga tgacactgcc acctctgact tctgcctctg
     1321 gccttcctct ctcagtaaga agagccaggc aggtgcttca gaactgggcc ctttttcaga
     1381 ccccaggcag ttcccaggca tttcatccct cactgagagc cgcttctcca acccacgaat
     1441 gcactatcca gccaccttca cttacacccc gccagtcacg tcaggcatgt ccctgggcat
     1501 gtccgccacc actcactacc acacgtacct gccaccaccc taccccggct cttcccaaag
     1561 ccagagcgga cccttccaga ccagcagcac tccatatctc tactatggta cttcgtcagc
     1621 gtcctatcag ttcccaatgg tccccggggg agaccggtct ccttccagga tggtcccacc
     1681 gtgcacgacc acctcgaatg gcagcacgct attaaatcca aatttgccta accagaatga
     1741 tggtgttgac gctgatggaa gccacagcag ctccccaacc gttttgaatt ctagcggcag
     1801 aatggatgag tctgtctggc gaccctattg aagtctgtca accgtgcatg gcccagtggc
     1861 atgcagtggc cacgtcccac atgtgttaat atatacatat ataaagagag tgcctatata
     1921 tgtatattga ttagctatct agaagatttc tcattcactc cccagttgtg atctggcaac
     1981 cctaagagtg tggggacagt cattactggg tttcatattg tttactattt aagatgtctc
     2041 ctctaccaag gagcagaccg tcaaaggtgt tatctggtct ggtttcgtaa gtgacctgtt
     2101 cccacaacaa ttcagagagg tggactctgg gtccgggagg aagaacggcc acttcctccc
     2161 tgtgctttgc aaccaaatca aggcctctgc tgtgtggagg cctgtgcact ctgcagacca
     2221 gcttacaaag ctgtggtgca ctcggaaagg gacgagaggc agcgtggctg cttcccctac
     2281 cgtccactct gaatacctgt tccaaagctt cccttcagac ttgatgcagg tatgcgtttg
     2341 aacttttgag ttcactcttt tttttttttt ttttctattc taagaaagtg acttcaaaaa
     2401 tactgatcag gacagattat tttattttac ttttttaaaa tattccctca cttcccccat
     2461 ttaaccaaaa aataagtccc attcccctcc cccgtgcctc ctgcttctcc ctttatgcaa
     2521 aactgaaaat ggcaatatct tattatagcc ataatgatat agtgtttgag ttggctgtgt
     2581 gttgtttgtt tttactttct ttttttcctt ttttaagtta tgaatatgtg taaaatctga
     2641 agtaacttgc taacgtgaat ggtcatataa ctttaaagat atatttataa ttatttaatg
     2701 acatttggac atttggaaca tttcttagtg taatggtctg ttgacttcgg tctctaaaag
     2761 tgcttcttct taaataacaa gtttcttcag tgggctagag ccatatcgga aatattgcta
     2821 agcaatttca attccttcag gcataatgtg attttttttt tttatgataa ctcccatttc
     2881 caaatatttt agttgtagtt ttgtttccat gatgtatgaa ggaaatgcta tgcttctttc
     2941 tttcaggtgt ttgattgcct ctgacacggc tttacctgtt aaagcaataa ttagggatta
     3001 aaaaacaaaa caaaacaaaa caaaaaccac ctataaccct gcagcccttt gacgcttaat
     3061 gcggcctctt tgctagcatt gaaatgctgg agacatgtgg tttcctaatt tcttcatttt
     3121 tggggggtgg ggggttggcc attatgagtc ttgtcatatt aaaaagccaa gcacaagtga
     3181 ttggccgaac tgcagaaaag tgttctgtgg tctcagagtt gagcagaact ctaaattgca
     3241 ggcttcgtgg ttgagggcct aggcagctga aagccacacg tgtagtaaag gctcaaccat
     3301 gacacgtaca gcctaggaac acagatgcat taggagtctg cacccccccc ccagccttac
     3361 cacacagcca ttcaggggaa cccaaaagtg ccttacccaa ggagccccca cccccaacag
     3421 cagctttgca ggaagtggaa tgaagtcaat gtcctagggg agctggtcag ctgaagtagt
     3481 agctgatgtc agtagacaca gagcctgtgg ggacctccag gaagcctttg atactcaagg
     3541 ctctcactag ggagggccgt agagagcagg gaagacaatg tatgtagcag ttggtgtctg
     3601 ccatcgtgtg tgaacataag atccagccct cctaggagga cgtactgtga tcattcctgg
     3661 caccttgtgg ccaatccctg agtgtgactc cctaatccaa gccagagatc attcagtgac
     3721 accaccaggc aagtgctagc attcctcctg cacaaagtgt gtttgttggg ggttggggtt
     3781 gggggccacc ttcctttgaa tccagagcca ttctaagagt ccttcaggct tttgccttta
     3841 gcccctacac ccccttgctc tctgttcctt ctcaggttga cctttgtccc aatgtgggac
     3901 agtccagggg cagatgggga acttatgtgt gcctccaacc tgtgttttcc ctcaggattc
     3961 atcctgactc cttctgacac aaattgaggg ggaaagaaac ccacccagta gcaaaccgaa
     4021 acactttgcc ttctaaaggt tgtgtaccaa gtatgcacag atagatggtc aggccacctt
     4081 tgtgtttctt gagatggaat ttgtagctga tgctatttat tgtctgtgtg tggtagcttg
     4141 aagcacacca cggtccgtgt gtttgtctga tgcctatttc agcagcattt acaaaagtca
     4201 gtgtctggtt acacttttta gttttcatta atcgacatgg aaatgttacc accggtgcca
     4261 gctgcaccct atttaacttc ttttcaaagg cactatattt gtacattatt atttttttct
     4321 ttaacgttaa agggcttctt aaagtttaca atacagttat taagggacta gaggggatgc
     4381 cttagtgccc aaatgttatt acagtggctg caggcagcaa cccagaaaca tttttgaaaa
     4441 caggttgttt ccctccatcc tcccttattt gggaaaaatt caagtgcttt cttcaccctt
     4501 cagccacctc acagggtgac tcccgttaca acagtctccc ccattccccc actatgtttt
     4561 aaattttccc cttcccctcc ctttatctct taaactcttc atttgcactg ggtcacatgt
     4621 atgatttgtg gttttaagac caaagcaatg tcttaatact ctcctgggac tgttttcgtg
     4681 tacaaacttc cctgggctta gatggacatg gttctcgaag gagcacaaac atggctgaga
     4741 tttgcagtgg gaccgacaca gccatataaa aaaaaatgct cttcagttat ctcagaattt
     4801 taacctaggc cacagttcct aacgggcacc atggctttgg tttcaggtta gggaatgagg
     4861 cgcacccagc ccataataga aagacttacc agatttaact agttggctct catccttccc
     4921 tccgagaccc taagaaaacg aacagagcaa catctccaca tcattagaga ctgtccacag
     4981 taggttcaga agggagcagc catgttgggg gttctccttg ctccaaggaa aggcactgac
     5041 tgacctagtt ttagagaaca gtagcgggag catttgcatc cacagtgttt gagagggtaa
     5101 taaacaataa aagatgattc tcccagcctt tgaattcatt gttcttaaag atgatgatgc
     5161 atctaaaaca aagatttttt ttttctcctc ctatgtggga actttcttcg ttgtctgttt
     5221 acttcatgtt tacaaataat tgtttgcttt ttaatgcagt actttaaaaa tatatcagcc
     5281 aaaaccataa cgtacagtaa tttcttaggt attctgaata aaattccatg tctttcgata
     5341 tgcctactgt tcttaggttt ctgcggaaca acaacaacaa caacaacaaa aaaattgtag
     5401 cattttgtgt aaataacagc tttcgttctt atttttttat ttctctgatt gctattgccc
     5461 aagatttgct ttccatgcac atattgtaca aattctgctt tgtaccacac aggtcacgat
     5521 tgtggatgag tttactctga acttcaaagg gactatttgt attgtatgtt gcaactgtaa
     5581 attgaattat ttggcatttt ctcccctcat gattgtaata ttaatttgaa gtttgaattt
     5641 aattttcaat aaaaaggctt tttttttc
//
LOCUS       NM_001039035            1051 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 7
            (Srsf7), mRNA.
ACCESSION   NM_001039035 XM_343003
VERSION     NM_001039035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Ding,S., Shi,J., Qian,W., Iqbal,K., Grundke-Iqbal,I., Gong,C.X. and
            Liu,F.
  TITLE     Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
  JOURNAL   Neurobiol Aging 33 (7), 1389-1399 (2012)
   PUBMED   21215488
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Piekielko-Witkowska,A., Wiszomirska,H., Wojcicka,A., Poplawski,P.,
            Boguslawska,J., Tanski,Z. and Nauman,A.
  TITLE     Disturbed expression of splicing factors in renal cancer affects
            alternative splicing of apoptosis regulators, oncogenes, and tumor
            suppressors
  JOURNAL   PLoS One 5 (10), e13690 (2010)
   PUBMED   21082031
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Wang,J., Gao,Q.S., Wang,Y., Lafyatis,R., Stamm,S. and Andreadis,A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Zhang,H., Wada,J., Kanwar,Y.S., Tsuchiyama,Y., Hiragushi,K.,
            Hida,K., Shikata,K. and Makino,H.
  TITLE     Screening for genes up-regulated in 5/6 nephrectomized mouse kidney
  JOURNAL   Kidney Int 56 (2), 549-558 (1999)
   PUBMED   10432394
REFERENCE   10 (bases 1 to 1051)
  AUTHORS   Cavaloc,Y., Popielarz,M., Fuchs,J.P., Gattoni,R. and Stevenin,J.
  TITLE     Characterization and cloning of the human splicing factor 9G8: a
            novel 35 kDa factor of the serine/arginine protein family
  JOURNAL   EMBO J 13 (11), 2639-2649 (1994)
   PUBMED   8013463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM084661.1, FM085512.1, JAXUCZ010000006.1, FM092264.1 and
            FM079490.1.
            
            On Sep 14, 2010 this sequence version replaced NM_001039035.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.1186195.1,
                                           SRR22399492.812506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               FM084661.1         1-395
            396-481             FM085512.1         390-475
            482-516             JAXUCZ010000006.1  20566878-20566912
            517-658             FM092264.1         1-142
            659-667             JAXUCZ010000006.1  20567136-20567144
            668-845             FM079490.1         65-242
            846-1051            FM092264.1         321-526
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1051
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="serine and arginine rich splicing factor 7"
                     /db_xref="GeneID:362687"
                     /db_xref="RGD:1307425"
     exon            1..123
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="upstream in-frame stop codon"
     CDS             96..812
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="splicing factor, arginine/serine-rich 7, 35kDa"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 7"
                     /protein_id="NP_001034124.2"
                     /db_xref="GeneID:362687"
                     /db_xref="RGD:1307425"
                     /translation="MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIAR
                     NPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDP
                     NDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASP
                     RRSRSVSLRRSRSASLRRSRSGSIIGSRYFQSRSRSRSRSRSISRPRSSRSKSRSPSP
                     KRSRSPSGSPHRSASPERMD"
     misc_feature    129..359
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     serine/arginine-rich splicing factor 7 (SRSF7); Region:
                     RRM_SRSF7; cd12646"
                     /db_xref="CDD:410050"
     misc_feature    129..359
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     serine/arginine-rich splicing factor 7 (SRSF7); Region:
                     RRM_SRSF7; cd12646"
                     /db_xref="CDD:410050"
     misc_feature    order(216..218,222..230,240..242,246..248,339..341,
                     345..347)
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:410050"
     misc_feature    order(216..218,222..230,240..242,246..248,339..341,
                     345..347)
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:410050"
     exon            124..304
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            305..481
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            482..556
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            557..667
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            668..721
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            722..757
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1051
                     /gene="Srsf7"
                     /gene_synonym="Sfrs7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggatca ctggcagagg aggttgtgta gccgcttccg tgctactcgc gctgtgagca
       61 ttgcaagcta gagccgagta cgcgggccgg ccatcatgtc acgttacggg cggtatggag
      121 gagaaaccaa ggtatatgtt ggtaacctgg gaactggcgc tggtaaagga gagttagaaa
      181 gggcattcag ttactatggg cccttaagaa ctgtatggat tgccagaaat cctccaggat
      241 ttgcctttgt ggaatttgaa gaccctagag atgcagagga tgcagttcga ggattggatg
      301 ggaaagtgat ttgtggttct cgagtgaggg ttgaattatc aacaggcatg cctcggagat
      361 ctcggtttga taggccacct gcccgtcgtc cctttgatcc taatgataga tgctatgagt
      421 gtggtgaaaa gggacattat gcttatgact gtcatcgcta tagccgacga agaagaagca
      481 ggtcacgatc tagatcacat tcccgatcca ggggaaggcg atactctcgc tcacgtagta
      541 ggagccgcgg taggaggtca agatcagcat ctcctcgacg atcaaggtcc gtgtctcttc
      601 gtagatcaag atcagcttca ctcagaagat ctaggtctgg ttctataata ggatcgaggt
      661 atttccaatc ccgctcaagg tcgagatcaa gatccaggtc tatttcacga ccaagaagca
      721 gccgatcaaa atccagatct ccatctccta aaagaagtcg ttccccatca ggaagtccac
      781 acagaagtgc aagtccagaa agaatggact gaagttctca agttcacccg ttagggaaaa
      841 gttattttgt ttacattatt ataagggatt tgttatgtct gtaaagtgta acctaggaag
      901 gttcatcaac catctaatca aaatggatct ggattattac tctgtaaaat tcacagcagt
      961 aaatattgtt tttgttgaat gtattaacat cttatggtct ggaaatgtag gtttttattt
     1021 gacacattta aataaaatgt ttctaactag a
//
LOCUS       NM_012870               2832 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus TNF receptor superfamily member 11B (Tnfrsf11b),
            mRNA.
ACCESSION   NM_012870
VERSION     NM_012870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Wu,Z., Duan,S., Li,M., Zhang,A., Yang,H., Luo,J., Cheng,R. and
            Hu,T.
  TITLE     Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an
            experimental rat apical periodontitis model
  JOURNAL   Int Endod J 57 (9), 1315-1325 (2024)
   PUBMED   38923421
  REMARK    GeneRIF: Autophagy regulates bone loss via the RANKL/RANK/OPG axis
            in an experimental rat apical periodontitis model.
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Zhou,J., Guo,L., Yang,Y., Liu,Y. and Zhang,C.
  TITLE     Mechanical force regulates root resorption in rats through RANKL
            and OPG
  JOURNAL   BMC Oral Health 22 (1), 290 (2022)
   PUBMED   35842599
  REMARK    GeneRIF: Mechanical force regulates root resorption in rats through
            RANKL and OPG.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Tomaszewska,E., Rudyk,H., Swietlicka,I., Hulas-Stasiak,M.,
            Donaldson,J., Arczewska,M., Muszynski,S., Dobrowolski,P., Puzio,I.,
            Kushnir,V., Brezvyn,O., Muzyka,V. and Kotsyumbas,I.
  TITLE     The Influence of Prenatal Fumonisin Exposure on Bone Properties, as
            well as OPG and RANKL Expression and Immunolocalization, in Newborn
            Offspring Is Sex and Dose Dependent
  JOURNAL   Int J Mol Sci 22 (24), 13234 (2021)
   PUBMED   34948030
  REMARK    GeneRIF: The Influence of Prenatal Fumonisin Exposure on Bone
            Properties, as well as OPG and RANKL Expression and
            Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Sabry,M., Mostafa,S., Kamar,S., Rashed,L. and Estaphan,S.
  TITLE     The cross-talk between matrix metalloproteinase-9, RANKL/OPG system
            and cardiovascular risk factors in ovariectomized rat model of
            postmenopausal osteoporosis
  JOURNAL   PLoS One 16 (10), e0258254 (2021)
   PUBMED   34610044
  REMARK    GeneRIF: The cross-talk between matrix metalloproteinase-9,
            RANKL/OPG system and cardiovascular risk factors in ovariectomized
            rat model of postmenopausal osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   Wang,L.Y., Wang,B., Cong,B.B., Cui,T., Du,Y.Q. and Song,Y.
  TITLE     [Effect of different orthodontic forces on the expression of T
            helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats]
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 39 (2), 143-152 (2021)
   PUBMED   33834668
  REMARK    GeneRIF: [Effect of different orthodontic forces on the expression
            of T helper cell 17 cell-related cytokines in the pressure side of
            periodontal tissue in rats].
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Cundy,T., Hegde,M., Naot,D., Chong,B., King,A., Wallace,R.,
            Mulley,J., Love,D.R., Seidel,J., Fawkner,M., Banovic,T.,
            Callon,K.E., Grey,A.B., Reid,I.R., Middleton-Hardie,C.A. and
            Cornish,J.
  TITLE     A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an
            idiopathic hyperphosphatasia phenotype
  JOURNAL   Hum Mol Genet 11 (18), 2119-2127 (2002)
   PUBMED   12189164
REFERENCE   7  (bases 1 to 2832)
  AUTHORS   Wise,G.E., Yao,S., Zhang,Q. and Ren,Y.
  TITLE     Inhibition of osteoclastogenesis by the secretion of
            osteoprotegerin in vitro by rat dental follicle cells and its
            implications for tooth eruption
  JOURNAL   Arch Oral Biol 47 (3), 247-254 (2002)
   PUBMED   11839361
  REMARK    GeneRIF: except for the period of time in tooth eruption, where
            osteoclast formation is needed to form an eruption pathway,
            secretion of OPG (osteoprotegerin) prevents resorption of alveolar
            bone and subsequent disruption of the periodontal ligament
REFERENCE   8  (bases 1 to 2832)
  AUTHORS   Yang,X., Halladay,D., Onyia,J.E., Martin,T.J. and Chandrasekhar,S.
  TITLE     Protein Kinase C is a mediator of the synthesis and secretion of
            osteoprotegerin in osteoblast-like cells
  JOURNAL   Biochem Biophys Res Commun 290 (1), 42-46 (2002)
   PUBMED   11779130
REFERENCE   9  (bases 1 to 2832)
  AUTHORS   Gold,B.G., Zeleny-Pooley,M., Chaturvedi,P. and Wang,M.S.
  TITLE     Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds
            nerve regeneration
  JOURNAL   Neuroreport 9 (3), 553-558 (1998)
   PUBMED   9512405
REFERENCE   10 (bases 1 to 2832)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R. and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081830.1.
            
            On Sep 16, 2004 this sequence version replaced NM_012870.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081830.1, U94330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..2832
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="TNF receptor superfamily member 11B"
                     /db_xref="GeneID:25341"
                     /db_xref="RGD:619802"
     exon            1..137
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    84..86
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="upstream in-frame stop codon"
     CDS             105..1310
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Osteoprotegerin"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11B precursor"
                     /protein_id="NP_037002.1"
                     /db_xref="GeneID:25341"
                     /db_xref="RGD:619802"
                     /translation="MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKC
                     APGTYLKQHCTVRRKTLCVPCPDYSYTDSWHTSDECVYCSPVCKELQTVKQECNRTHN
                     RVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNTVCKRCPDGFFSGETSSKAPC
                     RKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFAVPTKIIPN
                     WLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDL
                     CESSVQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRI
                     KNGDQDTLKGLMYALKHLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQ
                     VQSVKISCL"
     sig_peptide     105..167
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    123..557
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Tumor necrosis factor receptor superfamily member
                     11B (TNFRSF11B), also known as Osteoprotegerin (OPG);
                     Region: TNFRSF11B; cd10581"
                     /db_xref="CDD:276907"
     misc_feature    123..557
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Tumor necrosis factor receptor superfamily member
                     11B (TNFRSF11B), also known as Osteoprotegerin (OPG);
                     Region: TNFRSF11B; cd10581"
                     /db_xref="CDD:276907"
     misc_feature    123..290
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD1 [structural motif]; Region: CRD1"
                     /db_xref="CDD:276907"
     misc_feature    123..290
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD1 [structural motif]; Region: CRD1"
                     /db_xref="CDD:276907"
     mat_peptide     168..1307
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /product="Tumor necrosis factor receptor superfamily
                     member 11B. /id=PRO_0000034589"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1)"
     misc_feature    174..290
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1);
                     Region: TNFR-Cys 1"
     misc_feature    297..419
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD2 [structural motif]; Region: CRD2"
                     /db_xref="CDD:276907"
     misc_feature    297..419
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD2 [structural motif]; Region: CRD2"
                     /db_xref="CDD:276907"
     misc_feature    297..419
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1);
                     Region: TNFR-Cys 2"
     misc_feature    396..398
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1); glycosylation site"
     misc_feature    423..539
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD3 [structural motif]; Region: CRD3"
                     /db_xref="CDD:276907"
     misc_feature    423..539
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD3 [structural motif]; Region: CRD3"
                     /db_xref="CDD:276907"
     misc_feature    423..530
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1);
                     Region: TNFR-Cys 3"
     misc_feature    474..>665
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); Region: TNFRSF; cl22855"
                     /db_xref="CDD:473981"
     misc_feature    474..>665
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); Region: TNFRSF; cl22855"
                     /db_xref="CDD:473981"
     misc_feature    537..662
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD2 [structural motif]; Region: CRD2"
                     /db_xref="CDD:276924"
     misc_feature    537..662
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="CRD2 [structural motif]; Region: CRD2"
                     /db_xref="CDD:276924"
     misc_feature    537..659
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="propagated from UniProtKB/Swiss-Prot (O08727.1);
                     Region: TNFR-Cys 4"
     misc_feature    597..599
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1); glycosylation site"
     misc_feature    636..638
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1); glycosylation site"
     misc_feature    936..1199
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Death domain; Region: Death; pfam00531"
                     /db_xref="CDD:459845"
     misc_feature    936..1199
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Death domain; Region: Death; pfam00531"
                     /db_xref="CDD:459845"
     misc_feature    969..971
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08727.1); glycosylation site"
     misc_feature    1302..1304
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /note="Involved in dimerization. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (O08727.1); other
                     site"
     exon            138..504
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            505..696
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            697..921
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
     exon            922..2786
                     /gene="Tnfrsf11b"
                     /gene_synonym="Opg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgttgcc cagaccttat ataaaacgtc atgttcgcct gggcagcaga gaagcaccta
       61 gcactggccc agcggctgcc gcctgaggtt tccagaggac cacaatgaac aagtggctgt
      121 gctgtgcact cctggtgttc ttggacatca ttgaatggac aacccaggaa acctttcctc
      181 caaaatactt gcattatgac ccagaaaccg gacgtcagct cttgtgtgac aaatgtgctc
      241 ctggcaccta cctaaaacag cactgcacag tcaggaggaa gacactgtgt gtcccttgcc
      301 ctgactactc ttatacagac agctggcaca cgagtgatga atgcgtgtac tgcagccccg
      361 tgtgcaagga actgcagacc gtgaaacagg agtgcaaccg cacccacaac cgagtgtgcg
      421 aatgtgagga agggcgctac ctggagctcg aattctgctt gaagcaccgg agctgtcccc
      481 caggcttggg tgtgctgcag gctgggaccc cagagcgaaa cacggtttgc aaaagatgtc
      541 cggatgggtt cttctcaggt gagacgtcat cgaaagcacc ctgtaggaaa cacaccaact
      601 gcagctcact tggcctcctg ctaattcaga aaggaaatgc aacacatgac aatgtatgtt
      661 ccggaaacag agaagcaact caaaattgtg gaatagatgt caccctgtgc gaagaggcat
      721 tcttcaggtt tgctgtgcct accaagatta taccgaattg gctgagtgtt ctggtggaca
      781 gtttgcctgg gaccaaagtg aatgcagaga gtgtagagag gataaaacgg agacacagct
      841 cgcaagagca aactttccag ctacttaagc tgtggaagca tcaaaacaga gaccaggaaa
      901 tggtgaagaa gatcatccaa gacattgacc tctgtgaaag cagtgtgcaa cggcatatcg
      961 gccacgcgaa cctcaccaca gagcagctcc gcatcttgat ggagagcttg cctgggaaga
     1021 agatcagccc agacgagatt gagagaacga gaaagacctg caaacccagc gagcagctcc
     1081 tgaagctact gagcttgtgg aggatcaaaa atggagacca agacaccttg aagggcctga
     1141 tgtacgcact caagcacttg aaagcatacc actttcccaa aaccgtcacc cacagtctga
     1201 ggaagaccat caggttcttg cacagcttca ccatgtaccg attgtatcag aaactctttc
     1261 tagaaatgat agggaatcag gttcaatcag tgaagataag ctgcttatag ttaggaatgg
     1321 tcactgggct gtttcttcag gatgggccaa cactgatgga gcagatggct gcttctccgg
     1381 ctcttgaaat ggcagttgat tcctttctca tcagttggtg ggaatgaaga tcctccagcc
     1441 caacacacac actggggagt ctgagtcagg agagtgaggc aggctatttg ataattgtgc
     1501 aaagctgcca ggtgtacacc tagaaagtca agcaccctga gaaagaggat atttttataa
     1561 cctcaaacat aggccctttc cttcctctcc ttatggatga gtactcagaa ggcttctact
     1621 atcttctgtg tcatccctag atgaaggcct cttttattta tttttttatt ctttttttcg
     1681 gagctgggga ccgaacccag ggccttgcgc ttgcgaggca agtgctctac cactgagcta
     1741 aatctccaac ccctgaaggc ctctttcttt ctgcctctga tagtctatga cattcttttt
     1801 tctacaattc gtatcaggtg cacgagcctt atcccatttg taggtttcta ggcaagttga
     1861 ccgttagcta tttttccctc tgaagatttg attcgagttg cagacttggc tagacaagca
     1921 ggggtaggtt atggtagttt atttaacaga ctgccaccag gagtccagtg tttcttgttc
     1981 ctctgtagtt gtacctaagc tgactccaag tacatttagt atgaaaaata atcaacaaat
     2041 tttattcctt ctatcaacat tggctagctt tgtttcaggg cactaaaaga aactactata
     2101 tggagaaaga attgatattg cccccaacgt tcaacaaccc aatagtttat ccagctgtca
     2161 tgcctggttc agtgtctact gactatgcgc cctcttatta ctgcatgcag taattcaact
     2221 ggaaatagta ataataataa tagaaataaa atctagactc cattggatct ctctgaatat
     2281 gggaatatct aacttaagaa gctttgagat ttcagttgtg ttaaaggctt ttattaaaaa
     2341 gctgatgctc ttctgtaaaa gttactaata tatctgtaag actattacag tattgctatt
     2401 tatatccatc cagatatatt ttgtacatat tataatccta gagagaaatg tcgtaggatt
     2461 taattttaga aagaaaaaaa ttctgtttac tattgtgaca aataaaagag ataaaatata
     2521 tttttaatag aaactttgta gtgttttcca ataggtacta tcaggtttcc agtgtggaat
     2581 gtttttataa tataatttta tctgtataaa atgtaatatc attttataga aaaatgtatt
     2641 atgtactcag ttgtttgtca gaaagtgtat gaactataaa ttatctaaat attagatgct
     2701 ctgagaaatt gaatgtacct ttatttaagg atttttgtga tcgcactata taaataacat
     2761 cattaaagtt ttcaaattat ttttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa aa
//
LOCUS       NM_001278484            5410 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus RUNX family transcription factor 2 (Runx2),
            transcript variant 2, mRNA.
ACCESSION   NM_001278484
VERSION     NM_001278484.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5410)
  AUTHORS   Gopinathan,G., Luan,X. and Diekwisch,T.G.H.
  TITLE     Epigenetic Repression of RUNX2 and OSX Promoters Controls the
            Nonmineralized State of the Periodontal Ligament
  JOURNAL   Genes (Basel) 14 (1), 201 (2023)
   PUBMED   36672941
  REMARK    GeneRIF: Epigenetic Repression of RUNX2 and OSX Promoters Controls
            the Nonmineralized State of the Periodontal Ligament.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5410)
  AUTHORS   Ma,Z., Wang,Y., Xue,Y., Zhang,W., Li,D., Li,Y., Li,G., Zhou,H.,
            Hu,X., Deng,T. and Hu,K.
  TITLE     Traumatic temporomandibular joint bony ankylosis in growing rats
  JOURNAL   BMC Oral Health 22 (1), 585 (2022)
   PUBMED   36494653
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5410)
  AUTHORS   Xie,S., Chen,M., Fang,W., Liu,S., Wu,Q., Liu,C., Xing,Y., Shi,W.,
            Xu,M., Zhang,M., Chen,S., Zeng,X., Wang,S., Deng,W. and Tang,Q.
  TITLE     Diminished arachidonate 5-lipoxygenase perturbs phase separation
            and transcriptional response of Runx2 to reverse pathological
            ventricular remodeling
  JOURNAL   EBioMedicine 86, 104359 (2022)
   PUBMED   36395739
  REMARK    GeneRIF: Diminished arachidonate 5-lipoxygenase perturbs phase
            separation and transcriptional response of Runx2 to reverse
            pathological ventricular remodeling.
REFERENCE   4  (bases 1 to 5410)
  AUTHORS   Zhou,W., Feng,Q., Cheng,M., Zhang,D., Jin,J., Zhang,S., Bai,Y. and
            Xu,J.
  TITLE     LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2
  JOURNAL   Cell Signal 91, 110220 (2022)
   PUBMED   34923106
  REMARK    GeneRIF: LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2.
REFERENCE   5  (bases 1 to 5410)
  AUTHORS   Wang,G., Wang,Z., Gao,S., Wang,Y. and Li,Q.
  TITLE     Curcumin enhances the proliferation and myelinization of Schwann
            cells through Runx2 to repair sciatic nerve injury
  JOURNAL   Neurosci Lett 770, 136391 (2022)
   PUBMED   34902518
REFERENCE   6  (bases 1 to 5410)
  AUTHORS   Xiao,Z.S., Thomas,R., Hinson,T.K. and Quarles,L.D.
  TITLE     Genomic structure and isoform expression of the mouse, rat and
            human Cbfa1/Osf2 transcription factor
  JOURNAL   Gene 214 (1-2), 187-197 (1998)
   PUBMED   9651525
REFERENCE   7  (bases 1 to 5410)
  AUTHORS   Thirunavukkarasu,K., Mahajan,M., McLarren,K.W., Stifani,S. and
            Karsenty,G.
  TITLE     Two domains unique to osteoblast-specific transcription factor
            Osf2/Cbfa1 contribute to its transactivation function and its
            inability to heterodimerize with Cbfbeta
  JOURNAL   Mol Cell Biol 18 (7), 4197-4208 (1998)
   PUBMED   9632804
REFERENCE   8  (bases 1 to 5410)
  AUTHORS   Mundlos,S., Otto,F., Mundlos,C., Mulliken,J.B., Aylsworth,A.S.,
            Albright,S., Lindhout,D., Cole,W.G., Henn,W., Knoll,J.H.,
            Owen,M.J., Mertelsmann,R., Zabel,B.U. and Olsen,B.R.
  TITLE     Mutations involving the transcription factor CBFA1 cause
            cleidocranial dysplasia
  JOURNAL   Cell 89 (5), 773-779 (1997)
   PUBMED   9182765
REFERENCE   9  (bases 1 to 5410)
  AUTHORS   Ducy,P., Zhang,R., Geoffroy,V., Ridall,A.L. and Karsenty,G.
  TITLE     Osf2/Cbfa1: a transcriptional activator of osteoblast
            differentiation
  JOURNAL   Cell 89 (5), 747-754 (1997)
   PUBMED   9182762
REFERENCE   10 (bases 1 to 5410)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 29, 2022 this sequence version replaced NM_001278484.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1250638.1,
                                           SRR26360181.250837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               JAXUCZ010000009.1  23743240-23743669
            431-587             JAXUCZ010000009.1  23753580-23753736
            588-692             JAXUCZ010000009.1  23760516-23760620
            693-866             JAXUCZ010000009.1  23818195-23818368
            867-1028            JAXUCZ010000009.1  23837869-23838030
            1029-1094           JAXUCZ010000009.1  23867080-23867145
            1095-5410           JAXUCZ010000009.1  23868867-23873182
FEATURES             Location/Qualifiers
     source          1..5410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5410
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="RUNX family transcription factor 2"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
     exon            1..430
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="upstream in-frame stop codon"
     CDS             26..1573
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     core-binding factor subunit alpha-1; osteoblast-specific
                     transcription factor 2; runt-related transcription factor
                     2"
                     /codon_start=1
                     /product="runt-related transcription factor 2 isoform 2"
                     /protein_id="NP_001265413.1"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
                     /translation="MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQ
                     QQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIAD
                     HPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSA
                     ELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGP
                     REPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQ
                     SQITDPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRIS
                     DDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPGISSLTESRFSNPRMHYPATF
                     TYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSASYQF
                     PMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMD
                     ESVWRPY"
     misc_feature    311..697
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    311..697
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runt domain; Region: Runt; pfam00853"
                     /db_xref="CDD:459963"
     misc_feature    <803..1450
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <803..1450
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    1295..1570
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     misc_feature    1295..1570
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="Runx inhibition domain; Region: RunxI; pfam08504"
                     /db_xref="CDD:430037"
     exon            431..587
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..692
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..866
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1028
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1094
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..5410
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcgctaa cttgtggctg ttgtgatgcg tattcccgta gatccgagca ccagccggcg
       61 cttcagcccc ccctccagca gcctgcagcc cggcaagatg agcgacgtga gcccggtagt
      121 ggctgctcag cagcagcagc agcagcagca gcagcagcag cagcagcaac agcagcaaca
      181 gcagcagcag cagcagcaac agcagcagca gcagcagcag gaggcggccg cagcagcagc
      241 agcggcagcg gcggcggcag cagcggcggc agccgtgccc cggttgaggc cgccgcacga
      301 caaccgcacc atggtggaga tcatcgcgga ccacccggcc gaactggtcc gcaccgacag
      361 ccccaacttc ctgtgctccg tgctgccctc gcactggcgg tgcaacaaga ccctgcccgt
      421 ggccttcaag gttgtagccc tcggagaggt acccgatggg accgtggtta ccgtcatggc
      481 cgggaatgat gagaactact ctgccgagct acgaaatgcc tctgctgtta tgaaaaacca
      541 agtggccagg ttcaacgatc tgagatttgt aggccggagc ggacgaggca agagtttcac
      601 tttgaccata acggtcttca caaatcctcc ccaagtggcc acttaccaca gagctattaa
      661 agtgacagtg gacggtcccc gggaaccaag aaggcacaga cagaagcttg atgactctaa
      721 acctagtttg ttctctgacc gcctcagtga tttagggcgc attcctcatc ccagtatgag
      781 agtaggtgtc ccgcctcaga acccacggcc ctccctgaac tcagcaccaa gtccttttaa
      841 tccacaagga cagagtcaga ttacagatcc caggcagaca caatcctccc caccgtggtc
      901 ctatgaccag tcttacccct cttatctgag ccagatgacg tccccatcca tccattccac
      961 cacgccgctg tcttccacac ggggcactgg gctgccagcc atcaccgacg tacccaggcg
     1021 tatttcagat gatgacactg ccacctctga cttctgcctc tggccttcct ctctcagtaa
     1081 gaagagccag gcaggtgctt cagaactggg ccctttttca gaccccaggc agttcccagg
     1141 catttcatcc ctcactgaga gccgcttctc caacccacga atgcactatc cagccacctt
     1201 cacttacacc ccgccagtca cgtcaggcat gtccctgggc atgtccgcca ccactcacta
     1261 ccacacgtac ctgccaccac cctaccccgg ctcttcccaa agccagagcg gacccttcca
     1321 gaccagcagc actccatatc tctactatgg tacttcgtca gcgtcctatc agttcccaat
     1381 ggtccccggg ggagaccggt ctccttccag gatggtccca ccgtgcacga ccacctcgaa
     1441 tggcagcacg ctattaaatc caaatttgcc taaccagaat gatggtgttg acgctgatgg
     1501 aagccacagc agctccccaa ccgttttgaa ttctagcggc agaatggatg agtctgtctg
     1561 gcgaccctat tgaagtctgt caaccgtgca tggcccagtg gcatgcagtg gccacgtccc
     1621 acatgtgtta atatatacat atataaagag agtgcctata tatgtatatt gattagctat
     1681 ctagaagatt tctcattcac tccccagttg tgatctggca accctaagag tgtggggaca
     1741 gtcattactg ggtttcatat tgtttactat ttaagatgtc tcctctacca aggagcagac
     1801 cgtcaaaggt gttatctggt ctggtttcgt aagtgacctg ttcccacaac aattcagaga
     1861 ggtggactct gggtccggga ggaagaacgg ccacttcctc cctgtgcttt gcaaccaaat
     1921 caaggcctct gctgtgtgga ggcctgtgca ctctgcagac cagcttacaa agctgtggtg
     1981 cactcggaaa gggacgagag gcagcgtggc tgcttcccct accgtccact ctgaatacct
     2041 gttccaaagc ttcccttcag acttgatgca ggtatgcgtt tgaacttttg agttcactct
     2101 tttttttttt ttttttctat tctaagaaag tgacttcaaa aatactgatc aggacagatt
     2161 attttatttt acttttttaa aatattccct cacttccccc atttaaccaa aaaataagtc
     2221 ccattcccct cccccgtgcc tcctgcttct ccctttatgc aaaactgaaa atggcaatat
     2281 cttattatag ccataatgat atagtgtttg agttggctgt gtgttgtttg tttttacttt
     2341 ctttttttcc ttttttaagt tatgaatatg tgtaaaatct gaagtaactt gctaacgtga
     2401 atggtcatat aactttaaag atatatttat aattatttaa tgacatttgg acatttggaa
     2461 catttcttag tgtaatggtc tgttgacttc ggtctctaaa agtgcttctt cttaaataac
     2521 aagtttcttc agtgggctag agccatatcg gaaatattgc taagcaattt caattccttc
     2581 aggcataatg tgattttttt tttttatgat aactcccatt tccaaatatt ttagttgtag
     2641 ttttgtttcc atgatgtatg aaggaaatgc tatgcttctt tctttcaggt gtttgattgc
     2701 ctctgacacg gctttacctg ttaaagcaat aattagggat taaaaaacaa aacaaaacaa
     2761 aacaaaaacc acctataacc ctgcagccct ttgacgctta atgcggcctc tttgctagca
     2821 ttgaaatgct ggagacatgt ggtttcctaa tttcttcatt tttggggggt ggggggttgg
     2881 ccattatgag tcttgtcata ttaaaaagcc aagcacaagt gattggccga actgcagaaa
     2941 agtgttctgt ggtctcagag ttgagcagaa ctctaaattg caggcttcgt ggttgagggc
     3001 ctaggcagct gaaagccaca cgtgtagtaa aggctcaacc atgacacgta cagcctagga
     3061 acacagatgc attaggagtc tgcacccccc ccccagcctt accacacagc cattcagggg
     3121 aacccaaaag tgccttaccc aaggagcccc cacccccaac agcagctttg caggaagtgg
     3181 aatgaagtca atgtcctagg ggagctggtc agctgaagta gtagctgatg tcagtagaca
     3241 cagagcctgt ggggacctcc aggaagcctt tgatactcaa ggctctcact agggagggcc
     3301 gtagagagca gggaagacaa tgtatgtagc agttggtgtc tgccatcgtg tgtgaacata
     3361 agatccagcc ctcctaggag gacgtactgt gatcattcct ggcaccttgt ggccaatccc
     3421 tgagtgtgac tccctaatcc aagccagaga tcattcagtg acaccaccag gcaagtgcta
     3481 gcattcctcc tgcacaaagt gtgtttgttg ggggttgggg ttgggggcca ccttcctttg
     3541 aatccagagc cattctaaga gtccttcagg cttttgcctt tagcccctac acccccttgc
     3601 tctctgttcc ttctcaggtt gacctttgtc ccaatgtggg acagtccagg ggcagatggg
     3661 gaacttatgt gtgcctccaa cctgtgtttt ccctcaggat tcatcctgac tccttctgac
     3721 acaaattgag ggggaaagaa acccacccag tagcaaaccg aaacactttg ccttctaaag
     3781 gttgtgtacc aagtatgcac agatagatgg tcaggccacc tttgtgtttc ttgagatgga
     3841 atttgtagct gatgctattt attgtctgtg tgtggtagct tgaagcacac cacggtccgt
     3901 gtgtttgtct gatgcctatt tcagcagcat ttacaaaagt cagtgtctgg ttacactttt
     3961 tagttttcat taatcgacat ggaaatgtta ccaccggtgc cagctgcacc ctatttaact
     4021 tcttttcaaa ggcactatat ttgtacatta ttattttttt ctttaacgtt aaagggcttc
     4081 ttaaagttta caatacagtt attaagggac tagaggggat gccttagtgc ccaaatgtta
     4141 ttacagtggc tgcaggcagc aacccagaaa catttttgaa aacaggttgt ttccctccat
     4201 cctcccttat ttgggaaaaa ttcaagtgct ttcttcaccc ttcagccacc tcacagggtg
     4261 actcccgtta caacagtctc ccccattccc ccactatgtt ttaaattttc cccttcccct
     4321 ccctttatct cttaaactct tcatttgcac tgggtcacat gtatgatttg tggttttaag
     4381 accaaagcaa tgtcttaata ctctcctggg actgttttcg tgtacaaact tccctgggct
     4441 tagatggaca tggttctcga aggagcacaa acatggctga gatttgcagt gggaccgaca
     4501 cagccatata aaaaaaaatg ctcttcagtt atctcagaat tttaacctag gccacagttc
     4561 ctaacgggca ccatggcttt ggtttcaggt tagggaatga ggcgcaccca gcccataata
     4621 gaaagactta ccagatttaa ctagttggct ctcatccttc cctccgagac cctaagaaaa
     4681 cgaacagagc aacatctcca catcattaga gactgtccac agtaggttca gaagggagca
     4741 gccatgttgg gggttctcct tgctccaagg aaaggcactg actgacctag ttttagagaa
     4801 cagtagcggg agcatttgca tccacagtgt ttgagagggt aataaacaat aaaagatgat
     4861 tctcccagcc tttgaattca ttgttcttaa agatgatgat gcatctaaaa caaagatttt
     4921 ttttttctcc tcctatgtgg gaactttctt cgttgtctgt ttacttcatg tttacaaata
     4981 attgtttgct ttttaatgca gtactttaaa aatatatcag ccaaaaccat aacgtacagt
     5041 aatttcttag gtattctgaa taaaattcca tgtctttcga tatgcctact gttcttaggt
     5101 ttctgcggaa caacaacaac aacaacaaca aaaaaattgt agcattttgt gtaaataaca
     5161 gctttcgttc ttattttttt atttctctga ttgctattgc ccaagatttg ctttccatgc
     5221 acatattgta caaattctgc tttgtaccac acaggtcacg attgtggatg agtttactct
     5281 gaacttcaaa gggactattt gtattgtatg ttgcaactgt aaattgaatt atttggcatt
     5341 ttctcccctc atgattgtaa tattaatttg aagtttgaat ttaattttca ataaaaaggc
     5401 tttttttttc
//
LOCUS       NM_017196                686 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus allograft inflammatory factor 1 (Aif1), mRNA.
ACCESSION   NM_017196 NM_022283 XM_346597
VERSION     NM_017196.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 686)
  AUTHORS   Wu,Q., Qin,B., Wu,X., Zhang,M., Gan,Z., Lan,Y., Ma,C. and Fu,W.
  TITLE     Allograft inflammatory factor-1 enhances inflammation and oxidative
            stress via the NF-kappaB pathway of bladder urothelium in diabetic
            rat model
  JOURNAL   Cytokine 173, 156438 (2024)
   PUBMED   37976702
  REMARK    GeneRIF: Allograft inflammatory factor-1 enhances inflammation and
            oxidative stress via the NF-kappaB pathway of bladder urothelium in
            diabetic rat model.
REFERENCE   2  (bases 1 to 686)
  AUTHORS   Gheorghe,R.O., Grosu,A.V., Magercu,M., Ghenghea,M.S., Zbarcea,C.E.,
            Tanase,A., Negres,S., Filippi,A., Chiritoiu,G., Gherghiceanu,M.,
            Dinescu,S., Gaina,G., Sapunar,D. and Ristoiu,V.
  TITLE     Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1
            Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain
  JOURNAL   Int J Mol Sci 24 (21), 15831 (2023)
   PUBMED   37958812
  REMARK    GeneRIF: Switching Rat Resident Macrophages from M1 to M2 Phenotype
            by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic
            Pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 686)
  AUTHORS   Jeong,S., Yoon,K.S., Lee,J.M., Jo,E.S., Kim,D. and Choi,S.O.
  TITLE     Neurotoxic and cardiotoxic effects of
            N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and
            1-phenyl-2-pyrrolidinylpentane (prolintane)
  JOURNAL   Drug Chem Toxicol 46 (3), 430-440 (2023)
   PUBMED   35296205
  REMARK    GeneRIF: Neurotoxic and cardiotoxic effects of
            N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and
            1-phenyl-2-pyrrolidinylpentane (prolintane).
REFERENCE   4  (bases 1 to 686)
  AUTHORS   Gok,E. and Deveci,E.
  TITLE     Histopathological evaluation of IBA-1, GFAP activity in the brain
            cortex of rats administered cadmium chloride
  JOURNAL   Arch Ital Biol 160 (1-2), 20-27 (2022)
   PUBMED   35913387
  REMARK    GeneRIF: Histopathological evaluation of IBA-1, GFAP activity in
            the brain cortex of rats administered cadmium chloride.
REFERENCE   5  (bases 1 to 686)
  AUTHORS   Hung,T.W., Wu,K.J., Wang,Y.S., Bae,E.K., Song,Y., Yoon,J. and
            Yu,S.J.
  TITLE     Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke
  JOURNAL   Int J Mol Sci 22 (18), 9881 (2021)
   PUBMED   34576050
  REMARK    GeneRIF: Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 686)
  AUTHORS   Chen,Z.W., Ahren,B., Ostenson,C.G., Cintra,A., Bergman,T.,
            Moller,C., Fuxe,K., Mutt,V., Jornvall,H. and Efendic,S.
  TITLE     Identification, isolation, and characterization of daintain
            (allograft inflammatory factor 1), a macrophage polypeptide with
            effects on insulin secretion and abundantly present in the pancreas
            of prediabetic BB rats
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13879-13884 (1997)
   PUBMED   9391121
REFERENCE   7  (bases 1 to 686)
  AUTHORS   Imai,Y., Ibata,I., Ito,D., Ohsawa,K. and Kohsaka,S.
  TITLE     A novel gene iba1 in the major histocompatibility complex class III
            region encoding an EF hand protein expressed in a monocytic lineage
  JOURNAL   Biochem Biophys Res Commun 224 (3), 855-862 (1996)
   PUBMED   8713135
REFERENCE   8  (bases 1 to 686)
  AUTHORS   Autieri,M.V., Prystowsky,M.B. and Ohlstein,E.H.
  TITLE     Isolation and characterization of BART-1: A novel balloon
            angioplasty responsive transcript in rat carotid arteries
  JOURNAL   DNA Cell Biol 15 (4), 297-304 (1996)
   PUBMED   8639266
REFERENCE   9  (bases 1 to 686)
  AUTHORS   Autieri,M.V., Feuerstein,G.Z., Yue,T.L., Ohlstein,E.H. and
            Douglas,S.A.
  TITLE     Use of differential display to identify differentially expressed
            mRNAs induced by rat carotid artery balloon angioplasty
  JOURNAL   Lab Invest 72 (6), 656-661 (1995)
   PUBMED   7783423
REFERENCE   10 (bases 1 to 686)
  AUTHORS   Utans,U., Arceci,R.J., Yamashita,Y. and Russell,M.E.
  TITLE     Cloning and characterization of allograft inflammatory factor-1: a
            novel macrophage factor identified in rat cardiac allografts with
            chronic rejection
  JOURNAL   J Clin Invest 95 (6), 2954-2962 (1995)
   PUBMED   7769138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883046.1, FM053942.1 and BC081822.1.
            
            On Oct 1, 2009 this sequence version replaced NM_017196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000818.1, FQ231499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BX883046.1         23514-23526         c
            14-577              FM053942.1         1-564
            578-686             BC081822.1         1425-1533
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..686
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="allograft inflammatory factor 1"
                     /db_xref="GeneID:29427"
                     /db_xref="RGD:61924"
     exon            1..123
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    90..92
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="upstream in-frame stop codon"
     CDS             99..542
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="protein BART-1; balloon angioplasty responsive
                     transcript; ionized calcium binding adapter molecule 1;
                     AIF-1; microglia response factor; balloon
                     angioplasty-responsive transcript 1"
                     /codon_start=1
                     /product="allograft inflammatory factor 1"
                     /protein_id="NP_058892.1"
                     /db_xref="GeneID:29427"
                     /db_xref="RGD:61924"
                     /translation="MSQSKDLQGGKAFGLLKAQQEERLDGINKHFLDDPKYSSDEDLQ
                     SKLEAFKTKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIREVSSGSEETFS
                     YSDFLRMMLGKRSAILRMILMYEEKNKEHQKPTGPPAKKAISELP"
     misc_feature    102..104
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (P55009.1); acetylation site"
     misc_feature    129..131
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (P55009.1); acetylation site"
     misc_feature    210..>437
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="calmodulin; Provisional; Region: PTZ00184"
                     /db_xref="CDD:185504"
     misc_feature    210..>437
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="calmodulin; Provisional; Region: PTZ00184"
                     /db_xref="CDD:185504"
     misc_feature    213..215
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (P55009.1); phosphorylation site"
     misc_feature    477..539
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P55009.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            124..185
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..252
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..294
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..457
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..657
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaaggga ctggggagct ggtggagaga ggagccagcc aacacactgc agcctcatcg
       61 tcatctcccc acctaaggcc accagcgtct gaggagctat gagccagagc aaggatttgc
      121 agggaggaaa agcttttgga ctgctgaaag cccaacagga agagaggttg gatgggatca
      181 acaagcactt cctcgatgat cccaagtaca gcagtgatga ggatctgcag tccaaactgg
      241 aggccttcaa gacgaagtac atggagtttg atctgaatgg caatggagat atcgatatta
      301 tgtccttgaa gcgaatgctg gagaaacttg gggttcccaa gacccatcta gagctgaaga
      361 aattaattag agaggtgtcc agtggctccg aggagacgtt cagttactct gactttctca
      421 gaatgatgct gggcaagaga tctgccatct tgagaatgat tctgatgtat gaggagaaaa
      481 acaaagaaca ccagaagcca actggtcccc cagccaagaa agctatttct gagttgccct
      541 aattggaggt ggatataaca cggtgggacc gaggaccttc taatgacagc agcatgggaa
      601 aagaagaagc agttgtgagc cagagtcaaa ctaaataaat aatgctccct agtgcaaaaa
      661 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
LOCUS       NM_001025409            2035 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus histone deacetylase 1 (Hdac1), mRNA.
ACCESSION   NM_001025409 XM_216349
VERSION     NM_001025409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Dunaway,L.S., Cook,A.K., Kellum,C.E., Edell,C., Botta,D.,
            Molina,P.A., Sedaka,R.S., d'Uscio,L.V., Katusic,Z.S., Pollock,D.M.,
            Inscho,E.W. and Pollock,J.S.
  TITLE     Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14201 (2024)
   PUBMED   39007513
  REMARK    GeneRIF: Endothelial histone deacetylase 1 activity impairs kidney
            microvascular NO signaling in rats fed a high-salt diet.
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Yang,H.T., Wang,G., Zhu,P.C. and Xiao,Z.Y.
  TITLE     Silencing EIF3A ameliorates pulmonary arterial hypertension through
            HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
  JOURNAL   Exp Cell Res 426 (1), 113555 (2023)
   PUBMED   36921705
  REMARK    GeneRIF: Silencing EIF3A ameliorates pulmonary arterial
            hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and
            in vivo.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Chen,Y., Cai,K., Du,Y., Liu,Z. and Gong,Y.
  TITLE     HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21
            expression in metabolic syndrome-related liver injury
  JOURNAL   Biochem Cell Biol 101 (1), 52-63 (2023)
   PUBMED   36542845
  REMARK    GeneRIF: HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits
            FGF21 expression in metabolic syndrome-related liver injury.
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Pascoal,T.A., Chamoun,M., Lax,E., Wey,H.Y., Shin,M., Ng,K.P.,
            Kang,M.S., Mathotaarachchi,S., Benedet,A.L., Therriault,J.,
            Lussier,F.Z., Schroeder,F.A., DuBois,J.M., Hightower,B.G.,
            Gilbert,T.M., Zurcher,N.R., Wang,C., Hopewell,R., Chakravarty,M.,
            Savard,M., Thomas,E., Mohaddes,S., Farzin,S., Salaciak,A.,
            Tullo,S., Cuello,A.C., Soucy,J.P., Massarweh,G., Hwang,H.,
            Kobayashi,E., Hyman,B.T., Dickerson,B.C., Guiot,M.C., Szyf,M.,
            Gauthier,S., Hooker,J.M. and Rosa-Neto,P.
  TITLE     [11C]Martinostat PET analysis reveals reduced HDAC I availability
            in Alzheimer's disease
  JOURNAL   Nat Commun 13 (1), 4171 (2022)
   PUBMED   35853847
  REMARK    GeneRIF: [(11)C]Martinostat PET analysis reveals reduced HDAC I
            availability in Alzheimer's disease.
            Erratum:[Nat Commun. 2022 Oct 3;13(1):5833. doi:
            10.1038/s41467-022-33668-0. PMID: 36192402]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Grabowska,A., Sas-Nowosielska,H., Wojtas,B., Holm-Kaczmarek,D.,
            Januszewicz,E., Yushkevich,Y., Czaban,I., Trzaskoma,P.,
            Krawczyk,K., Gielniewski,B., Martin-Gonzalez,A., Filipkowski,R.K.,
            Olszynski,K.H., Bernas,T., Szczepankiewicz,A.A., Sliwinska,M.A.,
            Kanhema,T., Bramham,C.R., Bokota,G., Plewczynski,D.,
            Wilczynski,G.M. and Magalska,A.
  TITLE     Activation-induced chromatin reorganization in neurons depends on
            HDAC1 activity
  JOURNAL   Cell Rep 38 (7), 110352 (2022)
   PUBMED   35172152
  REMARK    GeneRIF: Activation-induced chromatin reorganization in neurons
            depends on HDAC1 activity.
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Cai,R.L., Yan-Neale,Y., Cueto,M.A., Xu,H. and Cohen,D.
  TITLE     HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9,
            two G2/M checkpoint Rad proteins
  JOURNAL   J Biol Chem 275 (36), 27909-27916 (2000)
   PUBMED   10846170
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Fuks,F., Burgers,W.A., Brehm,A., Hughes-Davies,L. and Kouzarides,T.
  TITLE     DNA methyltransferase Dnmt1 associates with histone deacetylase
            activity
  JOURNAL   Nat Genet 24 (1), 88-91 (2000)
   PUBMED   10615135
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Huang,Y., Myers,S.J. and Dingledine,R.
  TITLE     Transcriptional repression by REST: recruitment of Sin3A and
            histone deacetylase to neuronal genes
  JOURNAL   Nat Neurosci 2 (10), 867-872 (1999)
   PUBMED   10491605
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Bartl,S., Taplick,J., Lagger,G., Khier,H., Kuchler,K. and Seiser,C.
  TITLE     Identification of mouse histone deacetylase 1 as a growth
            factor-inducible gene
  JOURNAL   Mol Cell Biol 17 (9), 5033-5043 (1997)
   PUBMED   9271381
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097943.1.
            
            On Jul 15, 2005 this sequence version replaced XM_216349.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097943.1, BC107476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2035
                     /gene="Hdac1"
                     /note="histone deacetylase 1"
                     /db_xref="GeneID:297893"
                     /db_xref="RGD:1309799"
     exon            1..67
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1467
                     /gene="Hdac1"
                     /EC_number="3.5.1.98"
                     /note="HD1; protein deacetylase HDAC1; protein
                     decrotonylase HDAC1; protein deacylase HDAC1"
                     /codon_start=1
                     /product="histone deacetylase 1"
                     /protein_id="NP_001020580.1"
                     /db_xref="GeneID:297893"
                     /db_xref="RGD:1309799"
                     /translation="MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLN
                     YGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV
                     FDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI
                     LELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGK
                     GKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNL
                     TIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYF
                     EYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEE
                     SGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKE
                     KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKMA"
     misc_feature    28..1140
                     /gene="Hdac1"
                     /note="Histone deacetylase 1 (HDAC1); Region: HDAC1;
                     cd10010"
                     /db_xref="CDD:212534"
     misc_feature    28..1140
                     /gene="Hdac1"
                     /note="Histone deacetylase 1 (HDAC1); Region: HDAC1;
                     cd10010"
                     /db_xref="CDD:212534"
     misc_feature    43..981
                     /gene="Hdac1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QQW4.1);
                     Region: Histone deacetylase"
     misc_feature    238..240
                     /gene="Hdac1"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); acetylation site"
     misc_feature    order(436..441,463..468,544..546,550..552,808..810,
                     829..831,919..921,925..927)
                     /gene="Hdac1"
                     /note="active site"
                     /db_xref="CDD:212534"
     misc_feature    order(436..441,463..468,544..546,550..552,808..810,
                     829..831,919..921,925..927)
                     /gene="Hdac1"
                     /note="active site"
                     /db_xref="CDD:212534"
     misc_feature    676..678
                     /gene="Hdac1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); acetylation site"
     misc_feature    1186..1464
                     /gene="Hdac1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4QQW4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1195..1197
                     /gene="Hdac1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); phosphorylation site"
     misc_feature    1234..1236
                     /gene="Hdac1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92769; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); phosphorylation site"
     misc_feature    1243..1245
                     /gene="Hdac1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); phosphorylation site"
     misc_feature    1279..1281
                     /gene="Hdac1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); phosphorylation site"
     misc_feature    1285..1287
                     /gene="Hdac1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); phosphorylation site"
     misc_feature    1312..1314
                     /gene="Hdac1"
                     /note="N6-methylated lysine, by EHMT2.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (Q4QQW4.1); methylation site"
     exon            68..180
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..298
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..373
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..512
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..654
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..747
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..856
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..997
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1106
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1237
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1390
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1439
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..2010
                     /gene="Hdac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgggcgg cgagcaagat ggcgcagact cagggcacca agaggaaagt ctgttactac
       61 tacgacgggg atgttggaaa ctactattat ggacaagggc acccaatgaa gcctcaccga
      121 atccgaatga ctcataattt gctgctcaac tatggtctct accgaaaaat ggaaatctat
      181 cgtcctcaca aagccaacgc tgaggagatg accaagtacc acagcgacga ctacatcaag
      241 ttcttgcgtt ctattcgccc agacaatatg tctgaataca gcaagcagat gcagagattc
      301 aacgtgggtg aggactgtcc ggtatttgat ggcttgtttg agttctgtca gttgtccacg
      361 ggtggctctg tcgcgagtgc tgtgaaactc aataagcagc agacggacat cgctgtgaac
      421 tgggctgggg gcctgcacca tgcgaagaag tctgaagcat ccggcttctg ttacgtcaat
      481 gatattgtct tggccatcct ggaactgcta aagtatcacc agagggtgct gtatattgac
      541 attgacattc accatggcga tggcgtggaa gaggccttct ataccacaga ccgggtcatg
      601 actgtgtcct ttcataaata cggagagtac ttcccaggaa ctggggacct acgggatatt
      661 ggggctggca aaggcaagta ctacgccgtt aactacccac tgcgagatgg cattgatgat
      721 gagtcctatg aagccatctt taagccagtc atgtccaaag taatggagat gttccagcct
      781 agtgcagtgg tcctacagtg cggctcagac tccctgtctg gggatcggct aggttgcttc
      841 aatctgacca tcaaaggaca tgccaagtgt gtggagttcg tgaagagttt caacttgccg
      901 atgctaatgt tgggaggagg tggctatacc atccgtaatg tcgctcggtg ctggacttac
      961 gagacagctg tggccctgga cacagagatc cctaatgagc taccatacaa tgactacttt
     1021 gaatactttg gaccagattt caagcttcac atcagccctt ccaatatgac taaccagaac
     1081 actaatgaat acctggagaa gatcaagcag cggctctttg agaacttgag aatgctgccc
     1141 catgcccctg gggtccaaat gcaggccatc ccagaggatg ccatcccaga agagagcggt
     1201 gatgaggatg aggaagaccc tgacaaacga atttccatct gctcctctga caaacgcatt
     1261 gcctgtgagg aggaattctc tgattctgat gaggagggag aaggaggtcg caagaactct
     1321 tctaacttca aaaaagccaa aagagtcaaa acagaagatg aaaaagaaaa agatcccgag
     1381 gagaaaaaag aagtcacaga agaggagaaa accaaggagg agaagccaga agccaaaggg
     1441 gtcaaagaag aggtcaagat ggcctgagca aggtctgcag ctccatcttc tctccaagtc
     1501 ccttactttc cctcaatttc tcagatttta tattttctat tcctgtgtat ttatataaaa
     1561 tatattaaat ataacgtccc cagggactag atagggacca gcgcacaggg cagtggtact
     1621 gggagaactc ttcttcccag agctcccttg tccgtcctgc cctaggtctg agttttgaac
     1681 cacgtagggt ccaggtgaaa agaaaacaac cggaagacta aatcctgaac tgcaagtgcc
     1741 tgcttaggag ctctgctagg atggccttgt taagcttttc agcaggggcg actgtgtctt
     1801 ctggggcccc ttttcaggct tgggtaatat cagccatttt tagattggtt ctgtttctac
     1861 cttcccaccc accccgggca agcagaaaaa cttacactgc cccgtcttcc cccaattctg
     1921 caggtggagg ttgttagcct agcttccttt ttgagatatt ttcatttttg tgagactctt
     1981 tgtaataaaa cagcgcgttt ctataccttc aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_013414                487 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus bone gamma-carboxyglutamate protein (Bglap),
            mRNA.
ACCESSION   NM_013414
VERSION     NM_013414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Pinheiro,G.V.V.D.S., Sabino-Silva,R., Araujo,M.R., Gomes,S.P.,
            Oliveira,S.W., Aguiar,E.M.G., Cardoso-Sousa,L., Gonzaga,C.C. and
            Claudino,M.
  TITLE     Experimental Acute Sepsis Reduced Number of Osteocalcin
            Immunolabeled Cells in Periodontal Ligament
  JOURNAL   Braz Dent J 31 (2), 143-151 (2020)
   PUBMED   32556013
  REMARK    GeneRIF: acute sepsis induction resulted in reduced number of
            osteocalcin labelled cells in periodontal ligament region.
            Moreover, no significant histological differences were observed in
            the periodontium of rats under acute sepsis
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Sadek,N.B., Gamal,S.M., Aboulhoda,B.E., Rashed,L.A., Shawky,H.M.
            and Gamal El-Din,M.M.
  TITLE     The Potential Role of Undercarboxylated Osteocalcin Upregulation in
            Microvascular Insufficiency in a Rat Model of Diabetic
            Cardiomyopathy
  JOURNAL   J Cardiovasc Pharmacol Ther 25 (1), 86-97 (2020)
   PUBMED   31533469
  REMARK    GeneRIF: The Potential Role of Undercarboxylated Osteocalcin
            Upregulation in Microvascular Insufficiency in a Rat Model of
            Diabetic Cardiomyopathy.
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Qi,S., He,J., Zheng,H., Chen,C. and Lan,S.
  TITLE     Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing
            Blood Glucose and Suppressing Bone Turnover
  JOURNAL   Molecules 24 (10), 1871 (2019)
   PUBMED   31096652
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Wu,J.Z., Liu,P.C., Liu,R. and Cai,M.
  TITLE     Icariin Restores Bone Structure and Strength in a Rat Model of
            Chronic High-Dose Alcohol-Induced Osteopenia
  JOURNAL   Cell Physiol Biochem 46 (4), 1727-1736 (2018)
   PUBMED   29698972
REFERENCE   5  (bases 1 to 487)
  AUTHORS   Gao,J., Bai,T., Ren,L., Ding,Y., Zhong,X., Wang,H., Guo,Y., Li,J.,
            Liu,Y. and Zhang,Y.
  TITLE     The PLC/PKC/Ras/MEK/Kv channel pathway is involved in
            uncarboxylated osteocalcin-regulated insulin secretion in rats
  JOURNAL   Peptides 86, 72-79 (2016)
   PUBMED   27746193
  REMARK    GeneRIF: Uncarboxylated osteocalcin potentiates insulin secretion,
            inhibits Kv channels and increases [Ca(2+)]i.
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Thomas,S., Movsowitz,C., Epstein,S., Jowell,P. and Ismail,F.
  TITLE     The response of circulating parameters of bone mineral metabolism
            to ethanol- and EDTA-induced hypocalcemia in the rat
  JOURNAL   Bone Miner 8 (1), 1-6 (1990)
   PUBMED   2106357
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Theofan,G., Haberstroh,L.M. and Price,P.A.
  TITLE     Molecular structure of the rat bone Gla protein gene and
            identification of putative regulatory elements
  JOURNAL   DNA 8 (3), 213-221 (1989)
   PUBMED   2785907
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Lian,J., Stewart,C., Puchacz,E., Mackowiak,S., Shalhoub,V.,
            Collart,D., Zambetti,G. and Stein,G.
  TITLE     Structure of the rat osteocalcin gene and regulation of vitamin
            D-dependent expression
  JOURNAL   Proc Natl Acad Sci U S A 86 (4), 1143-1147 (1989)
   PUBMED   2784002
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Wientroub,S., Price,P.A. and Reddi,A.H.
  TITLE     The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and
            24,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic
            acid-containing protein in serum and bone in vitamin D-deficient
            rats
  JOURNAL   Calcif Tissue Int 40 (3), 166-172 (1987)
   PUBMED   3105848
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Celeste,A.J., Rosen,V., Buecker,J.L., Kriz,R., Wang,E.A. and
            Wozney,J.M.
  TITLE     Isolation of the human gene for bone gla protein utilizing mouse
            and rat cDNA clones
  JOURNAL   EMBO J 5 (8), 1885-1890 (1986)
   PUBMED   3019668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M25490.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11777.1, X04141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680429, SAMN06680433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..487
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="bone gamma-carboxyglutamate protein"
                     /db_xref="GeneID:25295"
                     /db_xref="RGD:2206"
     exon            1..113
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..349
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="gamma-carboxyglutamic acid-containing protein; bone
                     Gla-protein; osteocalcin; bone gamma-carboxyglutamate
                     protein 2; bone gamma-carboxyglutamate (gla) protein
                     (osteocalcin); bone gamma-carboxyglutamic acid (Gla)
                     protein (osteocalcin)"
                     /codon_start=1
                     /product="osteocalcin preproprotein"
                     /protein_id="NP_038200.1"
                     /db_xref="GeneID:25295"
                     /db_xref="RGD:2206"
                     /translation="MRTLSLLTLLALTAFCLSDLAGAKPSDSESDKAFMSKQEGSKVV
                     NRLRRYLNNGLGAPAPYPDPLEPHREVCELNPNCDELADHIGFQDAYKRIYGTTV"
     sig_peptide     50..118
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    140..334
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     misc_feature    140..334
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     mat_peptide     197..346
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /product="osteocalcin"
     misc_feature    221..223
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="Hydroxyproline.
                     /evidence=ECO:0000269|PubMed:3875856; propagated from
                     UniProtKB/Swiss-Prot (P04640.1); hydroxylation site"
     misc_feature    245..247
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="4-carboxyglutamate.
                     /evidence=ECO:0000250|UniProtKB:P02818,
                     ECO:0000255|PROSITE-ProRule:PRU00463; propagated from
                     UniProtKB/Swiss-Prot (P04640.1);
                     gamma-carboxyglutamic-acid site"
     misc_feature    257..259
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="4-carboxyglutamate.
                     /evidence=ECO:0000250|UniProtKB:P83489,
                     ECO:0000255|PROSITE-ProRule:PRU00463; propagated from
                     UniProtKB/Swiss-Prot (P04640.1);
                     gamma-carboxyglutamic-acid site"
     misc_feature    266..268
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="4-carboxyglutamate.
                     /evidence=ECO:0000250|UniProtKB:P83489,
                     ECO:0000255|PROSITE-ProRule:PRU00463; propagated from
                     UniProtKB/Swiss-Prot (P04640.1);
                     gamma-carboxyglutamic-acid site"
     exon            114..146
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     exon            147..216
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     exon            217..487
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagaca agtcccacac agcaactcgg tgcagaccta gcagacacca tgaggaccct
       61 ctctctgctc actctgctgg ccctgactgc attctgcctc tctgacctgg caggtgcaaa
      121 gcccagcgac tctgagtctg acaaagcctt catgtccaag caggagggca gtaaggtggt
      181 gaatagactc cggcgctacc tcaacaatgg acttggagcc ccagccccct acccagatcc
      241 cctggagcct cacagggagg tgtgtgagct caaccccaat tgtgacgagc tagcggacca
      301 cattggcttc caggacgcct acaagcgcat ctatggcacc accgtttagg gcatgtgttg
      361 ccctggagcc caacggcagc ttcagctttg gctactctcc aggactcgac cctccctgtt
      421 ccctctctct gcctcgaaag tatggacggc acagctgctc caaaataaag tccagatgag
      481 gaacggt
//
LOCUS       NM_022960               1740 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus aquaporin 9 (Aqp9), mRNA.
ACCESSION   NM_022960
VERSION     NM_022960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Wu,J., Wang,C. and Ding,H.
  TITLE     LncRNA MALAT1 promotes neuropathic pain progression through the
            miR-154-5p/AQP9 axis in CCI rat models
  JOURNAL   Mol Med Rep 21 (1), 291-303 (2020)
   PUBMED   31746418
  REMARK    GeneRIF: LncRNA MALAT1 promotes neuropathic pain progression
            through the miR1545p/AQP9 axis in CCI rat models.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Huang,X., Yu,X., Li,H., Han,L. and Yang,X.
  TITLE     Regulation mechanism of aquaporin 9 gene on inflammatory response
            and cardiac function in rats with myocardial infarction through
            extracellular signal-regulated kinase1/2 pathway
  JOURNAL   Heart Vessels 34 (12), 2041-2051 (2019)
   PUBMED   31218464
  REMARK    GeneRIF: the combination of AQP9 gene knock-down and U0126 showed
            no further effect. Silencing AQP9 gene can inhibit the activation
            of ERK1/2 signaling pathway, attenuate the inflammatory response in
            rats with MI, inhibit apoptosis of myocardial cells, and improve
            cardiac function
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   de Mello Santos,T., Cavariani,M.M., Pereira,D.N., Schimming,B.C.,
            Chuffa,L.G.A. and Domeniconi,R.F.
  TITLE     Maternal Protein Restriction Modulates Angiogenesis and AQP9
            Expression Leading to a Delay in Postnatal Epididymal Development
            in Rat
  JOURNAL   Cells 8 (9), 1094 (2019)
   PUBMED   31533210
  REMARK    GeneRIF: The maternal low-protein diet decreased AQP9 and VEGFr-2
            expression, decreased epididymal microvascularity and altered the
            morphometric features of the epididymal epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Liu,J.Y., Chen,X.X., Chen,H.Y., Shi,J., Leung,G.P., Tang,S.C.,
            Lao,L.X., Yip,H.K., Lee,K.F., Sze,S.C., Zhang,Z.J. and Zhang,K.Y.
  TITLE     Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced
            Neurotoxicity in Alzheimer's Disease Models In vitro and In vivo
  JOURNAL   Neuroscience 394, 72-82 (2018)
   PUBMED   30266683
  REMARK    GeneRIF: Downregulation of aquaporin 9 exacerbates
            beta-amyloid-induced neurotoxicity in Alzheimer's disease models in
            vitro and in vivo.
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Gotfryd,K., Mosca,A.F., Missel,J.W., Truelsen,S.F., Wang,K.,
            Spulber,M., Krabbe,S., Helix-Nielsen,C., Laforenza,U., Soveral,G.,
            Pedersen,P.A. and Gourdon,P.
  TITLE     Human adipose glycerol flux is regulated by a pH gate in AQP10
  JOURNAL   Nat Commun 9 (1), 4749 (2018)
   PUBMED   30420639
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Kuriyama,H., Kawamoto,S., Ishida,N., Ohno,I., Mita,S.,
            Matsuzawa,Y., Matsubara,K. and Okubo,K.
  TITLE     Molecular cloning and expression of a novel human aquaporin from
            adipose tissue with glycerol permeability
  JOURNAL   Biochem Biophys Res Commun 241 (1), 53-58 (1997)
   PUBMED   9405233
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085731.1.
            
            On Nov 15, 2004 this sequence version replaced NM_022960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1740
                     /gene="Aqp9"
                     /note="aquaporin 9"
                     /db_xref="GeneID:65054"
                     /db_xref="RGD:68433"
     exon            1..25
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            26..182
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            183..224
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            225..400
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            401..574
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    401..403
                     /gene="Aqp9"
                     /note="upstream in-frame stop codon"
     CDS             464..1351
                     /gene="Aqp9"
                     /note="AQP-9; aquaglyceroporin-9; neutral solute channel
                     aquaporin 9"
                     /codon_start=1
                     /product="aquaporin-9"
                     /protein_id="NP_075249.1"
                     /db_xref="GeneID:65054"
                     /db_xref="RGD:68433"
                     /translation="MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSI
                     AQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKF
                     PFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPG
                     AFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPA
                     RDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPD
                     MKAEPSENNLEKHELSVIM"
     misc_feature    473..1261
                     /gene="Aqp9"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    473..1261
                     /gene="Aqp9"
                     /note="Major intrinsic protein (MIP) superfamily. Members
                     of the MIP superfamily function as membrane channels that
                     selectively transport water, small neutral molecules, and
                     ions out of and between cells. The channel proteins share
                     a common fold: the N-terminal...; Region: MIP; cl00200"
                     /db_xref="CDD:444743"
     misc_feature    536..592
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     misc_feature    635..694
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     misc_feature    order(653..655,707..715,1097..1102,1109..1111,1118..1120)
                     /gene="Aqp9"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(653..655,707..715,1097..1102,1109..1111,1118..1120)
                     /gene="Aqp9"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     misc_feature    order(713..721,1109..1117)
                     /gene="Aqp9"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    order(713..721,1109..1117)
                     /gene="Aqp9"
                     /note="Asn-Pro-Ala signature motifs; other site"
                     /db_xref="CDD:238204"
     misc_feature    713..721
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     Region: NPA 1. /evidence=ECO:0000250|UniProtKB:Q96PS8"
     misc_feature    758..832
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     misc_feature    944..997
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     misc_feature    1034..1084
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     misc_feature    1109..1117
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     Region: NPA 2. /evidence=ECO:0000250|UniProtKB:Q96PS8"
     misc_feature    1193..1255
                     /gene="Aqp9"
                     /note="propagated from UniProtKB/Swiss-Prot (P56627.1);
                     transmembrane region"
     exon            575..701
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            702..839
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            840..958
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1176
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1718
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaggaagt ccccacagtt gcctggggaa gtcaatacaa ttatatgagt ttccctcata
       61 tcatccagct gtctgaggag agaagacttg aggaaaaacc catggccaag cgtacccaga
      121 gttgggcttg ggtatcaagg gtatagacaa gagccagcag gtcagtggaa ctcaagatgc
      181 agcctgcctc ctcagctgga aatgattgag gacctcctgc aaaggagaaa acaaatcatc
      241 agaaggctgg aattgtgtaa cacgaaaatc tcttctggac cgaggcccat ctctggtttg
      301 gcaacacaac caaagcagca tctcttttct catctcctgg gaaaaaaaaa aaaaaaagaa
      361 aggcaacaga gaaaaagtag ccagagacca gagaataaag tgaaggcagg gaaccgagca
      421 agcagacctt ggtggaaagt gtacctctgg cagaaacccc aagatgcctt ctgagaagga
      481 cggtgccaag aagagcctca tgcagaggct ggccctgaag agccggatag cgaaggagac
      541 actctccgag ttcctgggca cctttataat gattgtcctt ggatgtagct ctattgccca
      601 agcggtcctc agtcgagaac gttttggcgg gatcatcact atcaatattg gatttgcatc
      661 ggcagtcgtg atggctctct atgtgacatt tggtatctct gggggccaca tcaacccagc
      721 tgtgtctttt gcaatgtgcg cctttggaag gatggagtgg ttcaagttcc cattttatgt
      781 gggagcccag tttttgggag cctttgttgg ggctgcaacg gtctttggca tttattatga
      841 tggactcatg gcctttgctg gcggaaaact gctcgtcgta ggagaaaatg caacagcatt
      901 catttttgca acatatccag ctccattcat atccacgcca ggtgcctttg tagaccaagt
      961 ggtgtctacc atgttcctcc ttctgatcgt ctttgccatg tttgactcca gaaacctggg
     1021 tgtccccaga ggcctggagc ctgttgtcat tggcctcctg atcattgtcc tttcctgttc
     1081 tctcggactc aactctggct gtgccatgaa cccagctcga gacctcagtc ccaggctctt
     1141 cactgcactg gcaggatggg ggtttgaggt cttcacagtt ggaaataact tctggtggat
     1201 acctgtcgtg ggtcctatga ttggtgcttt cctgggaggt cttatctaca ttctttttat
     1261 ccaaatgcat cactcgaagc tcgacccaga catgaaggca gagccatctg agaacaacct
     1321 agagaaacac gagctcagtg tcatcatgta gtgggatggc cagatctgca gttaccgttc
     1381 atccagttct ttcttcagag aagatgtcac ctgtgtgcct atgcagactt ggggcggggg
     1441 aatctacctg tctgctagtt ttctctagcc aactgggaca aaaaaattac aaaggcatcc
     1501 gtggaaaact ccaccagtca cccctcccca gaatagcact gactgtttat gatgggtatt
     1561 tgatggaagt ccttactcct aggtgattgc taagaatttt gaaacttgac catgtgcttg
     1621 gctggatagc ctcagagacc tttttttacc ctgtatgaaa ttgtgtcatc aaaggctctg
     1681 tcttcacaat ctataaatac aacattctaa aactgaaaaa aaaaaaaaaa aaaaaaaaaa
//
LOCUS       NM_022668               1598 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus myelin oligodendrocyte glycoprotein (Mog), mRNA.
ACCESSION   NM_022668
VERSION     NM_022668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Ntountaniotis,D., Vanioti,Mu., Kordopati,G.G., Kellici,T.F.,
            Marousis,K.D., Mavromoustakos,T., Spyroulias,G.A., Golic
            Grdadolnik,S. and Tselios,T.V.
  TITLE     A combined NMR and molecular dynamics simulation study to determine
            the conformational properties of rat/mouse 35-55 myelin
            oligodendrocyte glycoprotein epitope implicated in the induction of
            experimental autoimmune encephalomyelitis
  JOURNAL   J Biomol Struct Dyn 35 (7), 1559-1567 (2017)
   PUBMED   27483998
  REMARK    GeneRIF: The aim of this work was to explore the conformational
            characteristics of rat/mouse MOG35-55 immunodominant epitope. The
            results are discussed in terms of rational design of altered
            peptide ligands or non-peptide mimetics based on rat MOG35-55 that
            could be served as potential inhibitors of experimental autoimmune
            encephalomyelitis.
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   von Budingen,H.C., Mei,F., Greenfield,A., Jahn,S., Shen,Y.A.,
            Reid,H.H., McKemy,D.D. and Chan,J.R.
  TITLE     The myelin oligodendrocyte glycoprotein directly binds nerve growth
            factor to modulate central axon circuitry
  JOURNAL   J Cell Biol 210 (6), 891-898 (2015)
   PUBMED   26347141
  REMARK    GeneRIF: Identify nerve growth factor as a binding partner for MOG
            and demonstrate that this interaction is capable of sequestering
            NGF from TrkA-expressing neurons to modulate axon growth and
            survival.
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Mony,J.T., Khorooshi,R. and Owens,T.
  TITLE     MOG extracellular domain (p1-125) triggers elevated frequency of
            CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater
            incidence of severe EAE
  JOURNAL   Mult Scler 20 (10), 1312-1321 (2014)
   PUBMED   24552747
  REMARK    GeneRIF: MOG(1-125) immunization resulted in an increased incidence
            of severe experimental autoimmune encephalomyelitis and was
            accompanied by an increased percentage of CXCR3-expressing CD4+ T
            cells producing IFNgamma in the CNS.
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Kitley,J., Waters,P., Woodhall,M., Leite,M.I., Murchison,A.,
            George,J., Kuker,W., Chandratre,S., Vincent,A. and Palace,J.
  TITLE     Neuromyelitis optica spectrum disorders with aquaporin-4 and
            myelin-oligodendrocyte glycoprotein antibodies: a comparative study
  JOURNAL   JAMA Neurol 71 (3), 276-283 (2014)
   PUBMED   24425068
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Salvati,S., Sanchez,M., Campeggi,L.M., Suchanek,G., Breitschop,H.
            and Lassmann,H.
  TITLE     Accelerated myelinogenesis by dietary lipids in rat brain
  JOURNAL   J Neurochem 67 (4), 1744-1750 (1996)
   PUBMED   8858961
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Birling,M.C. and Nussbaum,J.L.
  TITLE     Comparative immunohistochemical study of C1G5F2 antigen and
            myelin/oligodendrocyte glycoprotein (MOG) expression in brain of
            several animal species
  JOURNAL   Neurosci Lett 185 (1), 9-12 (1995)
   PUBMED   7731558
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Pham-Dinh,D., Mattei,M.G., Nussbaum,J.L., Roussel,G.,
            Pontarotti,P., Roeckel,N., Mather,I.H., Artzt,K., Lindahl,K.F. and
            Dautigny,A.
  TITLE     Myelin/oligodendrocyte glycoprotein is a member of a subset of the
            immunoglobulin superfamily encoded within the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 7990-7994 (1993)
   PUBMED   8367453
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Gardinier,M.V., Amiguet,P., Linington,C. and Matthieu,J.M.
  TITLE     Myelin/oligodendrocyte glycoprotein is a unique member of the
            immunoglobulin superfamily
  JOURNAL   J Neurosci Res 33 (1), 177-187 (1992)
   PUBMED   1453482
REFERENCE   10 (bases 1 to 1598)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087717.1.
            
            On Oct 13, 2007 this sequence version replaced NM_022668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087717.1, FQ214199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1598
                     /gene="Mog"
                     /note="myelin oligodendrocyte glycoprotein"
                     /db_xref="GeneID:24558"
                     /db_xref="RGD:3102"
     exon            1..170
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    38..40
                     /gene="Mog"
                     /note="upstream in-frame stop codon"
     CDS             89..826
                     /gene="Mog"
                     /note="dystonia 2, torsion (autosomal recessive)"
                     /codon_start=1
                     /product="myelin-oligodendrocyte glycoprotein precursor"
                     /protein_id="NP_073159.2"
                     /db_xref="GeneID:24558"
                     /db_xref="RGD:3102"
                     /translation="MAGVWSLSLPSCLLSLLLLLQLSCSYAGQFRVIGPGHPIRALVG
                     DEAELPCRISPGKNATGMEVGWYRSPFSRVVHLYRNGKDQDAEQAPEYRGRTELLKES
                     IGEGKVALRIQNVRFSDEGGYTCFFRDHSYQEEAAVELKVEDPFYWINPGVLALIALV
                     PMLLLQVSVGLVFLFLQHRLRGKLRAEVENLHRTFDPHFLRVPCWKITLFVIVPVLGP
                     LVALIICYNWLHRRLAGQFLEELRNPF"
     sig_peptide     89..169
                     /gene="Mog"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     170..823
                     /gene="Mog"
                     /product="Myelin-oligodendrocyte glycoprotein.
                     /id=PRO_0000014890"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63345.1)"
     misc_feature    176..514
                     /gene="Mog"
                     /note="Immunoglobulin (Ig)-like domain of myelin
                     oligodendrocyte glycoprotein (MOG); Region: IgV_MOG_like;
                     cd05713"
                     /db_xref="CDD:409378"
     misc_feature    176..514
                     /gene="Mog"
                     /note="Immunoglobulin (Ig)-like domain of myelin
                     oligodendrocyte glycoprotein (MOG); Region: IgV_MOG_like;
                     cd05713"
                     /db_xref="CDD:409378"
     misc_feature    176..247
                     /gene="Mog"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409378"
     misc_feature    176..247
                     /gene="Mog"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409378"
     misc_feature    179..193
                     /gene="Mog"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409378"
     misc_feature    179..193
                     /gene="Mog"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409378"
     misc_feature    200..214
                     /gene="Mog"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409378"
     misc_feature    200..214
                     /gene="Mog"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409378"
     misc_feature    221..247
                     /gene="Mog"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409378"
     misc_feature    221..247
                     /gene="Mog"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409378"
     misc_feature    248..274
                     /gene="Mog"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409378"
     misc_feature    248..274
                     /gene="Mog"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409378"
     misc_feature    260..262
                     /gene="Mog"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (Q63345.1); glycosylation site"
     misc_feature    order(266..271,326..328,359..361,470..475,479..484,
                     488..493)
                     /gene="Mog"
                     /note="Fab binding site [polypeptide binding]; other site"
                     /db_xref="CDD:409378"
     misc_feature    order(266..271,326..328,359..361,470..475,479..484,
                     488..493)
                     /gene="Mog"
                     /note="Fab binding site [polypeptide binding]; other site"
                     /db_xref="CDD:409378"
     misc_feature    272..289
                     /gene="Mog"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409378"
     misc_feature    272..289
                     /gene="Mog"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409378"
     misc_feature    275..289
                     /gene="Mog"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409378"
     misc_feature    275..289
                     /gene="Mog"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409378"
     misc_feature    290..346
                     /gene="Mog"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409378"
     misc_feature    290..346
                     /gene="Mog"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409378"
     misc_feature    302..328
                     /gene="Mog"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409378"
     misc_feature    302..328
                     /gene="Mog"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409378"
     misc_feature    329..340
                     /gene="Mog"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409378"
     misc_feature    329..340
                     /gene="Mog"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409378"
     misc_feature    350..472
                     /gene="Mog"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409378"
     misc_feature    350..472
                     /gene="Mog"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409378"
     misc_feature    371..388
                     /gene="Mog"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409378"
     misc_feature    371..388
                     /gene="Mog"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409378"
     misc_feature    404..430
                     /gene="Mog"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409378"
     misc_feature    404..430
                     /gene="Mog"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409378"
     misc_feature    449..475
                     /gene="Mog"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409378"
     misc_feature    449..475
                     /gene="Mog"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409378"
     misc_feature    473..481
                     /gene="Mog"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409378"
     misc_feature    473..481
                     /gene="Mog"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409378"
     misc_feature    479..514
                     /gene="Mog"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409378"
     misc_feature    479..514
                     /gene="Mog"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409378"
     misc_feature    482..514
                     /gene="Mog"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409378"
     misc_feature    482..514
                     /gene="Mog"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409378"
     misc_feature    554..616
                     /gene="Mog"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63345.1);
                     transmembrane region"
     misc_feature    713..775
                     /gene="Mog"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63345.1);
                     transmembrane region"
     exon            171..518
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            519..632
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            633..653
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            654..674
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            675..791
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            792..812
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1575
                     /gene="Mog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcttgg ggtaagggac atgcagccag agggccttag cttggcctga tcctgctgtc
       61 agggaccctg tccccagtaa ccataaagat ggccggtgtg tggagccttt ctctgcccag
      121 ctgcctcctg tccctgctcc tcctcctcca gttgtcatgc agctacgcag gacagttcag
      181 agtgataggg ccagggcatc ccatccgggc tttagttggg gatgaagcag aactgccgtg
      241 ccgtatatct cctgggaaga atgccacggg catggaggtg gggtggtacc gttctccctt
      301 ttcaagagtg gttcatctgt accgaaatgg caaggaccaa gacgcagagc aagcgcctga
      361 ataccgggga cgcacagagc ttctgaaaga gtctatcggc gagggaaagg ttgccctcag
      421 gatccagaac gtgaggttct cggatgaagg aggctacaca tgcttcttca gagaccactc
      481 ctaccaagaa gaagccgccg tggagttgaa agtagaagat cccttctact ggatcaaccc
      541 tggcgtgctg gctctcattg cccttgtgcc tatgctgctc ctgcaggtct ctgtaggcct
      601 tgtattcctc ttcctgcagc acagactgag aggaaaactc cgtgcagaag tcgagaatct
      661 ccatcggact tttgatcctc acttcctgag agtgccctgc tggaagataa cactgtttgt
      721 tattgtccct gttcttggac ccctggttgc tttgatcatc tgctacaact ggctgcaccg
      781 aagactggca ggacagtttc ttgaagagct aagaaacccc ttttgagtga tggtgcatct
      841 tcctggagcg aaggaaagcc tggcaggtcc ttggggatgt ctctcactgg cctctctgtt
      901 atggacacat tccaatctac atctacagaa acactcggga tcctgagtag aacttgattt
      961 tcctcccaca actgtctttc tttcctcagc tccttcctct aaatcttttt tgactcctgt
     1021 cttagtctgc ctctagaaaa caccccatga ctaaggccag ggagtctatc aggagacacc
     1081 tatgtaccag agtaatacag gagtgattct gccaaccagg acacccagcg cttcaacatt
     1141 acgatctaca gaacatcagc tctgcaaatg gtggatattt cttccagagc cacagtcttg
     1201 actgggaaga atatcagtgg ggagagtaag ggggtgaggg acagaagaac ccacaacatg
     1261 agggaaagct aaatgagcca gggtatgaat atgggagcct gaaccaaaac ctggagatta
     1321 aaaaaaaaag tcaaaagaat actgactgga tcagagcaac accatcttgc tttggcagcc
     1381 tggtgggagg accttgagaa gcaagggtcg agaactgggt ctgttctctc atttttctcc
     1441 tatcttattt gagtacccac tgtttggttt tttttttttt tttcttcttc gttttttcaa
     1501 caattactac ttggtggtgt atcagacaca aacaagctag gtgctaatta ataataatac
     1561 aagtttcttt gtgcaaaaaa aaaaaaaaaa aaaaaaaa
//
LOCUS       NM_001005560            3100 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus phospholipase A2 group VI (Pla2g6), transcript
            variant 1, mRNA.
ACCESSION   NM_001005560 NM_053892 XM_346803
VERSION     NM_001005560.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3100)
  AUTHORS   Kuwata,H., Yuzurihara,C., Kinoshita,N., Taki,Y., Ikegami,Y.,
            Washio,S., Hirakawa,Y., Yoda,E., Aiuchi,T., Itabe,H., Nakatani,Y.
            and Hara,S.
  TITLE     The group VIA calcium-independent phospholipase A2 and NFATc4
            pathway mediates IL-1beta-induced expression of chemokines CCL2 and
            CXCL10 in rat fibroblasts
  JOURNAL   FEBS J 285 (11), 2056-2070 (2018)
   PUBMED   29637744
  REMARK    GeneRIF: the transcriptional activation of nuclear factor of
            activated T-cell proteins (NFATs), but not nuclear factor-kappaB,
            by IL-1beta stimulation was markedly attenuated by the iPLA2
            inhibitor bromoenol lactone, and NFATc4 knockdown markedly
            attenuated the IL-1beta-induced expression of both CCL2 and CXCL10.
REFERENCE   2  (bases 1 to 3100)
  AUTHORS   Zhou,Z., Wang,Z., Guan,Q., Qiu,F., Li,Y., Liu,Z., Zhang,H., Dong,H.
            and Zhang,Z.
  TITLE     PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia
            Cardiomyocytes through PEDF Receptor/Phospholipase A2
  JOURNAL   Int J Mol Sci 17 (12), 2064 (2016)
   PUBMED   27973457
  REMARK    GeneRIF: PEDF can protect against hypoxia-induced activation of the
            NLRP3 inflammasome by inhibiting mitochondrial fission though
            PEDFR/iPLA2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3100)
  AUTHORS   Caporarello,N., Salmeri,M., Scalia,M., Motta,C., Parrino,C.,
            Frittitta,L., Olivieri,M., Toscano,M.A., Anfuso,C.D. and Lupo,G.
  TITLE     Role of cytosolic and calcium independent phospholipases A(2) in
            insulin secretion impairment of INS-1E cells infected by S. aureus
  JOURNAL   FEBS Lett 589 (24 Pt B), 3969-3976 (2015)
   PUBMED   26632509
  REMARK    GeneRIF: Data suggest glucose-induced insulin secretion is first
            up-regulated (acute infection), then down-regulated (chronic
            infection) in beta cells infected with S. aureus; Pla2g4a is
            up-regulated in acute infection; Pla2g6 is up-regulated in chronic
            infection.
REFERENCE   4  (bases 1 to 3100)
  AUTHORS   Rauckhorst,A.J., Pfeiffer,D.R. and Broekemeier,K.M.
  TITLE     The iPLA(2)gamma is identified as the membrane potential sensitive
            phospholipase in liver mitochondria
  JOURNAL   FEBS Lett 589 (18), 2367-2371 (2015)
   PUBMED   26206229
  REMARK    GeneRIF: membrane potential sensitive activity is the iPLA2gamma
REFERENCE   5  (bases 1 to 3100)
  AUTHORS   Takatani-Nakase,T. and Takahashi,K.
  TITLE     Leptin suppresses non-apoptotic cell death in ischemic rat
            cardiomyocytes by reduction of iPLA(2) activity
  JOURNAL   Biochem Biophys Res Commun 463 (1-2), 13-17 (2015)
   PUBMED   25979360
  REMARK    GeneRIF: Leptin was shown to significantly inhibit the activity of
            iPLA2, which is considered to play crucial roles in non-apoptotic
            cell death, resulting in effective prevention of ischemia-induced
            myocyte death.
REFERENCE   6  (bases 1 to 3100)
  AUTHORS   Jenkins,C.M., Han,X., Mancuso,D.J. and Gross,R.W.
  TITLE     Identification of calcium-independent phospholipase A2 (iPLA2)
            beta, and not iPLA2gamma, as the mediator of arginine
            vasopressin-induced arachidonic acid release in A-10 smooth muscle
            cells. Enantioselective mechanism-based discrimination of mammalian
            iPLA2s
  JOURNAL   J Biol Chem 277 (36), 32807-32814 (2002)
   PUBMED   12089145
  REMARK    GeneRIF: The agonist-stimulated release of arachidonic acid (AA)
            from cellular phospholipids in many cell types (e.g. myocytes,
            beta-cells, and neurons) has been demonstrated to be primarily
            mediated by calcium-independent phospholipases A(2) (iPLA(2)s).
REFERENCE   7  (bases 1 to 3100)
  AUTHORS   Seegers,H.C., Gross,R.W. and Boyle,W.A.
  TITLE     Calcium-independent phospholipase A(2)-derived arachidonic acid is
            essential for endothelium-dependent relaxation by acetylcholine
  JOURNAL   J Pharmacol Exp Ther 302 (3), 918-923 (2002)
   PUBMED   12183647
REFERENCE   8  (bases 1 to 3100)
  AUTHORS   Bloch-Shilderman,E., Abu-Raya,S., Trembovler,V., Boschwitz,H.,
            Gruzman,A., Linial,M. and Lazarovici,P.
  TITLE     Pardaxin stimulation of phospholipases A2 and their involvement in
            exocytosis in PC-12 cells
  JOURNAL   J Pharmacol Exp Ther 301 (3), 953-962 (2002)
   PUBMED   12023524
REFERENCE   9  (bases 1 to 3100)
  AUTHORS   Ma,Z., Ramanadham,S., Wohltmann,M., Bohrer,A., Hsu,F.F. and Turk,J.
  TITLE     Studies of insulin secretory responses and of arachidonic acid
            incorporation into phospholipids of stably transfected insulinoma
            cells that overexpress group VIA phospholipase A2 (iPLA2beta)
            indicate a signaling rather than a housekeeping role for iPLA2beta
  JOURNAL   J Biol Chem 276 (16), 13198-13208 (2001)
   PUBMED   11278673
REFERENCE   10 (bases 1 to 3100)
  AUTHORS   Ma,Z., Ramanadham,S., Kempe,K., Chi,X.S., Ladenson,J. and Turk,J.
  TITLE     Pancreatic islets express a Ca2+-independent phospholipase A2
            enzyme that contains a repeated structural motif homologous to the
            integral membrane protein binding domain of ankyrin
  JOURNAL   J Biol Chem 272 (17), 11118-11127 (1997)
   PUBMED   9111008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081916.1.
            
            On or before Oct 14, 2004 this sequence version replaced
            NM_053892.1, XM_346803.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3100
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="phospholipase A2 group VI"
                     /db_xref="GeneID:360426"
                     /db_xref="RGD:628867"
     exon            1..52
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="upstream in-frame stop codon"
     exon            53..302
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2517
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1; 85
                     kDa calcium-independent phospholipase A2; patatin-like
                     phospholipase domain-containing protein 9; intracellular
                     membrane-associated calcium-independent phospholipase A2
                     beta; 85/88 kDa calcium-independent phospholipase A2;
                     phospholipase A2, group VI (cytosolic,
                     calcium-independent); palmitoyl-CoA hydrolase;
                     2-lysophosphatidylcholine acylhydrolase"
                     /codon_start=1
                     /product="85/88 kDa calcium-independent phospholipase A2
                     isoform 1"
                     /protein_id="NP_001005560.1"
                     /db_xref="GeneID:360426"
                     /db_xref="RGD:628867"
                     /translation="MQFFGRLVNTLSSVTNLFSNPFRVKEVSLADYASSERVREEGQL
                     ILLQNASNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQYSSQLPPFYESSVQVL
                     HVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLAC
                     RKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNN
                     QGLTPLHLACQMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDS
                     NQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSASGNTALHVAVTRNRFDCVM
                     VLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIASK
                     ISKLITRKALLTLLKTVGADYHFPFIQGVSTEQSSAAGPHPFFSLDRTQPPTISLNNL
                     ELQDLMPVSRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVA
                     TKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLK
                     REFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLKPPT
                     QPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQG
                     NKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPD
                     GRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQ
                     KLVQLLLSP"
     misc_feature    130..132
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P97570.2); phosphorylation site"
     misc_feature    397..1314
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    397..1314
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    448..540
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    448..540
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    451..534
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8"
     misc_feature    order(544..546,550..552,562..567,574..582,586..591,
                     601..603,610..612,640..642,646..648,652..654,664..669,
                     676..684,688..693,703..705,712..714,742..744,748..750,
                     754..756,766..771,778..786,790..795,805..807,814..816)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(544..546,550..552,562..567,574..582,586..591,
                     601..603,610..612,640..642,646..648,652..654,664..669,
                     676..684,688..693,703..705,712..714,742..744,748..750,
                     754..756,766..771,778..786,790..795,805..807,814..816)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    544..642
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    544..642
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    544..636
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 1. /evidence=ECO:0000255"
     misc_feature    646..744
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    646..744
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    646..738
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 2. /evidence=ECO:0000255"
     misc_feature    748..837
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    748..837
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    748..837
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 3. /evidence=ECO:0000255"
     misc_feature    844..936
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 4. /evidence=ECO:0000255"
     misc_feature    order(949..951,955..957,967..972,976..978,982..987,
                     997..999,1006..1008,1033..1035,1039..1041,1045..1047,
                     1057..1062,1069..1077,1081..1086,1096..1098,1105..1107,
                     1132..1134,1138..1140,1144..1146,1156..1161,1168..1176,
                     1180..1185,1195..1197,1204..1206,1231..1233)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(949..951,955..957,967..972,976..978,982..987,
                     997..999,1006..1008,1033..1035,1039..1041,1045..1047,
                     1057..1062,1069..1077,1081..1086,1096..1098,1105..1107,
                     1132..1134,1138..1140,1144..1146,1156..1161,1168..1176,
                     1180..1185,1195..1197,1204..1206,1231..1233)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    949..1035
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    949..1035
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    949..1029
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 5. /evidence=ECO:0000255"
     misc_feature    1039..1134
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1039..1134
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1039..1128
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 6. /evidence=ECO:0000255"
     misc_feature    1138..1233
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1138..1233
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1138..1227
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 7. /evidence=ECO:0000255"
     misc_feature    1237..1302
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8"
     misc_feature    1534..2475
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Patatin-like phospholipase domain containing
                     protein 9; Region: Pat_PNPLA9; cd07212"
                     /db_xref="CDD:132851"
     misc_feature    1534..2475
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="Patatin-like phospholipase domain containing
                     protein 9; Region: Pat_PNPLA9; cd07212"
                     /db_xref="CDD:132851"
     misc_feature    1534..1596
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     transmembrane region"
     misc_feature    1549..1566
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: GXGXXG.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01161"
     misc_feature    order(1552..1557,1561..1563,1651..1653,2050..2052)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="active site"
                     /db_xref="CDD:132851"
     misc_feature    order(1552..1557,1561..1563,1651..1653,2050..2052)
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="active site"
                     /db_xref="CDD:132851"
     misc_feature    1627..1689
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     transmembrane region"
     misc_feature    1645..1659
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: GXSXG.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01161"
     misc_feature    1645..1659
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132851"
     misc_feature    1645..1659
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132851"
     misc_feature    2050..2058
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: DGA/G.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01161"
     misc_feature    2125..2154
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: Calmodulin-binding (1-9-14 motif).
                     /evidence=ECO:0000269|PubMed:11118454"
     misc_feature    2338..2373
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /note="propagated from UniProtKB/Swiss-Prot (P97570.2);
                     Region: Calmodulin-binding (IQ motif).
                     /evidence=ECO:0000269|PubMed:11118454"
     exon            303..518
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            519..702
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            703..890
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            891..987
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1170
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1279
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1444
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1523
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1687
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1838
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1975
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2130
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2298
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2372
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..3077
                     /gene="Pla2g6"
                     /gene_synonym="caI-PLA2; GVI PLA2; iPla2; iPLA2-beta;
                     PNPLA9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgtttgt ttgcggaagt taggagtgct gagaagtgct gagtaagctg agagcacagg
       61 ggcaggctgg gtcgcctacc tgtcccacat aggatgcagt tctttggacg cctcgttaac
      121 accctcagta gtgtcaccaa cttgttctca aacccattcc gggtaaagga ggtgtccttg
      181 gctgactatg cctcaagtga acgtgttcga gaggaagggc agctgatcct gttgcagaat
      241 gcttccaatc gtacctggga ctgtgtcctg gtcagcccta ggaacccaca gagtggcttc
      301 cgactcttcc aactggagtc agaggcagac gccctggtga acttccagca gtattcctcc
      361 cagctgccac cgttctatga gagctctgtg caggtcctgc atgtggaggt gctgcagcac
      421 ctgacggacc tcattcggaa ccaccccagc tggacagtga cgcacctggc cgtggaactt
      481 ggcattcggg agtgtttcca tcacagccgc atcatcagct gcgccaacag cacagagaat
      541 gaggagggct gtaccccact acatctggcc tgccgcaagg gtgacagtga gattctggtg
      601 gagttggtac agtactgcca cgcccagatg gatgtcactg acaacaaagg agagaccgcc
      661 ttccattatg ctgtgcaagg ggacaatccc caggtgctac agctcctagg aaagaatgcc
      721 tcagccggcc tgaaccaggt gaacaaccaa gggctgacgc cgctgcacct ggcctgccag
      781 atggggaagc aggagatggt gcgtgtcctg ctgctctgca atgcccgctg caacatcatg
      841 gggcccggtg gcttccccat ccacacagcc atgaagtttt cccagaaggg gtgtgctgaa
      901 atgattatca gcatggacag taaccagatc cacagcaagg atcctcgcta tggagccagc
      961 ccgctccact gggccaagaa cgctgagatg gcccgaatgc ttctgaagag gggctgtgac
     1021 gtggacagca caagtgcctc ggggaacaca gccctgcacg tggcggtgac gcgcaaccgc
     1081 tttgactgtg tcatggtgct gctgacctat ggggccaacg caggtgcccg aggagagcat
     1141 gggaacacac cactgcatct ggccatgtcg aaagataaca tggagatggt caaagccctc
     1201 attgtatttg gggcagaagt agacaccccg aatgactttg gggagactcc tgcattcata
     1261 gcttccaaga tcagcaagct gattaccagg aaggcgctct tgactctgct gaaaacggtg
     1321 ggggccgact accacttccc attcatacaa ggggtctcca cggagcagag ctctgcagct
     1381 ggacctcacc ccttcttctc cctggacaga actcagcctc caacgatcag cttaaacaac
     1441 ctagagcttc aggacctcat gcccgtctcc cgagcccgga agccagcgtt catcctgagc
     1501 tccatgaggg atgagaagcg aagccatgac cacctgctct gcttggatgg agggggcgtg
     1561 aagggcctgg tcatcatcca gcttctcatt gccattgaga aggcctcagg tgtggctacc
     1621 aaggacctct tcgactgggt ggcaggaacc agcacaggcg gcatcctggc cctggccatt
     1681 ctacacagta aatccatggc ctatatgcgt ggcgtgtact tccgtatgaa ggatgaggtg
     1741 tttcggggct cacggcccta tgagtctggg cccctggagg agttcctgaa gcgtgagttt
     1801 ggggagcaca ccaagatgac agatgtcaag aaacccaagg tgatgctgac agggacactg
     1861 tcagaccggc agccagcaga gctccacctc ttccggaatt acgacgcccc agaggccgtt
     1921 cgggaacctc gctgtacccc aaacattaac ctgaagccgc ccacccagcc tgcagaccag
     1981 ttagtatggc gggcagcccg gagcagtggg gcagccccaa cctatttccg gcccaatgga
     2041 cgcttcttgg atggtgggct gctggccaac aaccccacac tggatgccat gactgaaatc
     2101 catgagtaca atcaggatat gatccgcaag ggccagggca acaaggtgaa gaaactctcc
     2161 atagtcgtgt ctctggggac aggaaagtcc cctcaagtgc ctgtaacctg tgtagatgtc
     2221 tttcgtccca gcaacccttg ggaactggcc aagactgttt ttggagccaa ggaactgggc
     2281 aagatggtgg tggactgttg cacagatcca gatgggcggg ctgtggatcg tgcccgggcc
     2341 tggtgtgaga tggtcggtat ccagtacttc aggctgaacc cccagctagg ctcagacatc
     2401 atgctggacg aggtcagtga tgcagtgctg gtcaacgccc tctgggagac cgaggtctac
     2461 atctatgagc accgggagga gttccagaag cttgtccagc tgctgctatc tccctgagcc
     2521 cggccctgct ggcaggagtg cgccgggccg cctggcacac tgcgggccag gctggcctgc
     2581 cgctccatgt ccatctgaga ctagggctcg gagcaaacag gttccccatg aggcacctct
     2641 cctgatccat ccgcacttta ctactccagg ctgaaagccc agagttccct cggccccttc
     2701 ccctgactat gaaggacaac tgattccatc tactacccca tatatcagag atcaacacta
     2761 aggggccagt gtgcccagag ggccctccca ggctccctgg ccactgctgc ccaccccctc
     2821 tcccacttcc tgatgtcagg gattagagaa atggggttcc accccgtcat caggtgaaat
     2881 ccaggctaat gaaacccagc gccattccgc cattcgactt tgcccctcgc acctgcagcc
     2941 tctccaccct gcagccgccc cacaaggagc gctcctagct cccaaaggtc aatcctgtgc
     3001 acatgctctt ctctggaagg agagtgggga ggggctcaag gccacctcaa ctgtgaaata
     3061 aacggtttta cactcaaaaa aaaaaaaaaa aaaaaaaaaa
//
LOCUS       NM_133551               2855 bp    mRNA    linear   ROD 25-MAR-2025
DEFINITION  Rattus norvegicus phospholipase A2 group 4A (Pla2g4a), mRNA.
ACCESSION   NM_133551
VERSION     NM_133551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Yao,H.H., Min,Y.J., Hong,D.Y., Wang,L., Lu,X.Y. and Yang,Y.H.
  TITLE     [Electroacupuncture improves limb motor function by down-regulating
            cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells
            in rats with spinal cord injury]
  JOURNAL   Zhen Ci Yan Jiu 48 (8), 782-790 (2023)
   PUBMED   37614136
  REMARK    GeneRIF: [Electroacupuncture improves limb motor function by
            down-regulating cytosolic phospholi-pase A2 and reducing apoptosis
            of nerve cells in rats with spinal cord injury].
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Bera,A., Srivastava,A., Dubey,V., Dixit,A.B., Tripathi,M.,
            Sharma,M.C., Lalwani,S., Chandra,P.S. and Banerjee,J.
  TITLE     Altered hippocampal expression and function of cytosolic
            phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE)
  JOURNAL   Neurol Res 44 (8), 748-753 (2022)
   PUBMED   35285418
  REMARK    GeneRIF: Altered hippocampal expression and function of cytosolic
            phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Santerre-Anderson,J.L. and Werner,D.F.
  TITLE     Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent
            Neuronal cPLA2 Activity in Immature Cultured Cortical Preparations
  JOURNAL   Neurochem Res 45 (7), 1592-1601 (2020)
   PUBMED   32274627
  REMARK    GeneRIF: Ethanol Stimulation of Microglia Release Increases
            ERK1/2-Dependent Neuronal cPLA2 Activity in Immature Cultured
            Cortical Preparations.
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Rajagopal,S., Fitzgerald,A.A., Deep,S.N., Paul,S. and Poddar,R.
  TITLE     Role of GluN2A NMDA receptor in homocysteine-induced prostaglandin
            E2 release from neurons
  JOURNAL   J Neurochem 150 (1), 44-55 (2019)
   PUBMED   31125437
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Villamil-Ortiz,J.G. and Cardona-Gomez,G.P.
  TITLE     cPLA2 and desaturases underlie the tau hyperphosphorylation offset
            induced by BACE knock-down in neuronal primary cultures
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (11), 3696-3707 (2018)
   PUBMED   30251689
  REMARK    GeneRIF: Study utilizing glutamate excitotoxicity model in rat
            cortical primary cell cultures suggests for the first time a more
            direct action of BACE1 on the hyperphosphorylation state of tau
            (implemented in Alzheimer's disease pathogenesis) that is mediated
            through cPLA2 and desaturases SCD1 and FADS6 modulation during
            glutamate excitotoxicity.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Xia,P., Kramer,R.M. and King,G.L.
  TITLE     Identification of the mechanism for the inhibition of
            Na+,K(+)-adenosine triphosphatase by hyperglycemia involving
            activation of protein kinase C and cytosolic phospholipase A2
  JOURNAL   J Clin Invest 96 (2), 733-740 (1995)
   PUBMED   7635966
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Hanel,A.M. and Gelb,M.H.
  TITLE     Multiple enzymatic activities of the human cytosolic 85-kDa
            phospholipase A2: hydrolytic reactions and acyl transfer to
            glycerol
  JOURNAL   Biochemistry 34 (24), 7807-7818 (1995)
   PUBMED   7794891
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Owada,Y., Tominaga,T., Yoshimoto,T. and Kondo,H.
  TITLE     Molecular cloning of rat cDNA for cytosolic phospholipase A2 and
            the increased gene expression in the dentate gyrus following
            transient forebrain ischemia
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 364-368 (1994)
   PUBMED   7808237
  REMARK    Erratum:[Brain Res Mol Brain Res. 1994 Dec;27(2):355. doi:
            10.1016/0169-328x(94)90023-x. PMID: 7898324]
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Kitayama,S., Shimada,S. and Uhl,G.R.
  TITLE     Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in
            nonneuronal COS cells expressing dopamine transporter cDNA
  JOURNAL   Ann Neurol 32 (1), 109-111 (1992)
   PUBMED   1642464
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Tovey,J.A., Sundar,A.S., Ikram,S., Smith,S. and Penny,W.J.
  TITLE     Human cardiac muscle magnesium and potassium concentrations: can
            skeletal muscle, mononuclear blood cells, erythrocyte and plasma
            concentrations provide a surrogate measure?
  JOURNAL   Ann Clin Biochem 29 (Pt 4), 461-462 (1992)
   PUBMED   1642455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070940.1.
            
            On Mar 8, 2007 this sequence version replaced NM_133551.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070940.1, U38376.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2855              BC070940.1         1-2855
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2855
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="phospholipase A2 group 4A"
                     /db_xref="GeneID:24653"
                     /db_xref="RGD:67366"
     exon            1..105
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            106..204
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2430
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2 cytosolic; phospholipase A2, group
                     IVA (cytosolic, calcium-dependent); cytosolic
                     phospholipase A2-like; phospholipase A2 group IVA"
                     /codon_start=1
                     /product="cytosolic phospholipase A2"
                     /protein_id="NP_598235.2"
                     /db_xref="GeneID:24653"
                     /db_xref="RGD:67366"
                     /translation="MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDP
                     YVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETL
                     GTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQ
                     RKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGIL
                     DCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYV
                     ESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSTTLSSLKEKVSAARCPLPLFTCLHV
                     KPDVSELMFADWVEFSPYEIGMAKYGTFMTPDLFGSKFFMGTVVKKYEENPLHFLMGV
                     WGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENE
                     DAEREYQNDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLR
                     DFSPQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQR
                     GVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK
                     PKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFN
                     FQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFN
                     KEFLSKPTAESI"
     misc_feature    172..705
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="propagated from UniProtKB/Swiss-Prot (P50393.1);
                     Region: Phospholipid binding. /evidence=ECO:0000305"
     misc_feature    175..177
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47712; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    229..585
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); Region: C2_cPLA2; cd04036"
                     /db_xref="CDD:176001"
     misc_feature    229..585
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); Region: C2_cPLA2; cd04036"
                     /db_xref="CDD:176001"
     misc_feature    order(289..291,298..300,364..366,448..450,454..456)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:176001"
     misc_feature    order(289..291,298..300,364..366,448..450,454..456)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:176001"
     misc_feature    601..2361
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Group IVA cytosolic phospholipase A2; catalytic
                     domain; Ca-dependent; Region: cPLA2_Grp-IVA; cd07200"
                     /db_xref="CDD:132839"
     misc_feature    601..2361
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Group IVA cytosolic phospholipase A2; catalytic
                     domain; Ca-dependent; Region: cPLA2_Grp-IVA; cd07200"
                     /db_xref="CDD:132839"
     misc_feature    order(760..765,769..771,853..855,1816..1818)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="active site"
                     /db_xref="CDD:132839"
     misc_feature    order(760..765,769..771,853..855,1816..1818)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="active site"
                     /db_xref="CDD:132839"
     misc_feature    847..861
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132839"
     misc_feature    847..861
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="nucleophile elbow; other site"
                     /db_xref="CDD:132839"
     misc_feature    973..975
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47712; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    order(1378..1380,1627..1629)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="flexible lid region; other site"
                     /db_xref="CDD:132839"
     misc_feature    order(1378..1380,1627..1629)
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="flexible lid region; other site"
                     /db_xref="CDD:132839"
     misc_feature    1450..1542
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="propagated from UniProtKB/Swiss-Prot (P50393.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1471..1473
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    1474..1476
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47712; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    1480..1482
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    1684..1686
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:P47712; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    1702..1704
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    1714..1716
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    2350..2352
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     misc_feature    2356..2358
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47712; propagated from
                     UniProtKB/Swiss-Prot (P50393.1); phosphorylation site"
     exon            205..286
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            287..435
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            436..549
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..587
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            588..729
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..866
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1089
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1204
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1342
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1435
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1507
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1750
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1935
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2131
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2289
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2833
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttctcaaa gtcggaactg tgaagggctc ccatcagggc tcccgactga cagagagcta
       61 gaaggcacag agaaacctga ggattctcat ttaactctgg gaactgcttc aagaagctat
      121 agtaccagag aacacctggg aagtgtgaga attcctgcag ctgggaccaa aatgtctttc
      181 atagatcctt atcagcacat aatagtggaa caccagtatt cccataagtt tacagtagtg
      241 gttctacgtg ccaccaaagt aaccaagggg acctttggcg atatgctgga cactcctgat
      301 ccttatgtgg aacttttcat ctctacaacc cctgacagca ggaagcgaac aagacacttc
      361 aataatgata taaaccctgt gtggaatgag acctttgagt tcattttgga tcctaatcag
      421 gaaaatgttt tggagatcac attgatggat gccaattacg tcatggatga aaccctaggc
      481 acagctacat ttcctgtatc ttctatgaag gtgggagaga agaaagaagt cccttttatt
      541 ttcaaccaag tcacagaaat gattctggaa atgtctcttg aagtttgctc atgcccagac
      601 ctacggttca gcatggcact gtgtgatcag gagaaaacat tcaggcagca gaggaaagag
      661 aacataaaag agaacatgaa gaaacttttg ggtccaaaaa agagcgaggg gctttattcc
      721 acacgtgatg tgcctgtggt ggccattttg ggttccggcg ggggtttccg ggccatggtg
      781 ggattctccg gtgtgatgaa ggcgctctat gaatcaggga ttttggattg tgcgacctac
      841 gttgctggtc tgtccggctc cacatggtac atgtcaacct tgtactccca ccctgatttt
      901 ccagagaaag gtcctgagga gattaatgaa gagctaatga aaaatgttag ccacaaccct
      961 ctcttacttc ttacgccaca gaaagttaaa agatatgttg agtctttatg gaagaagaaa
     1021 agttctggcc aacctgtcac ctttactgac atctttggaa tgttaatagg agaaacacta
     1081 attcaaaata gaatgagtac gaccttgagt agcttgaagg aaaaggtcag cgccgcccgg
     1141 tgtcctctgc ctctcttcac ctgtctccat gtcaaaccgg acgtgtcaga gctgatgttt
     1201 gccgattggg tagaatttag tccatacgaa attggcatgg caaaatatgg tacctttatg
     1261 actcctgacc tgtttggaag caaatttttt atgggaacag ttgtaaaaaa atatgaagaa
     1321 aaccccttgc atttcttaat gggtgtctgg ggcagtgcct tttctatact gttcaacaga
     1381 gttttgggag tttctggctc acagaataaa ggttctacaa tggaggagga attagaaaat
     1441 attacagcaa agcacattgt gagtaacgac agctctgaca gcgatgacga ggcccaagga
     1501 cccaaaggca ccgagaatga agatgcggaa agagagtacc aaaatgacaa ccaagcaagt
     1561 tgggtccatc ggatgctaat ggccttggtg agtgactcag ctttattcaa tacccgagaa
     1621 ggacgtgctg ggaaggtgca taacttcatg ttgggcttga atctcaacac atcgtatcca
     1681 ctgtctcccc tgagagactt cagcccccaa gattccttcg atgatgatga actcgacgca
     1741 gcggtagcag atccagatga atttgaacga atatatgaac cactggatgt caaaagtaaa
     1801 aagattcatg ttgtagacag tgggctcacg tttaacctgc cgtatccctt gattctgcga
     1861 cctcagagag gtgtggatct catcatttcc tttgactttt ctgcaaggcc aagtgacacc
     1921 agccctccat tcaaggaact tctgcttgca gagaagtggg ctaaaatgaa caagctccct
     1981 tttccaaaga ttgatcctta cgtgtttgat cgggaaggat tgaaggaatg ctatgtgttt
     2041 aaacctaaga atcctgatgt ggagaaggat tgcccaacca ttatccactt tgttctggcc
     2101 aacatcaact tcagaaagta caaggcccca ggtgttctga gggaaaccaa ggaagagaaa
     2161 gaaatagctg actttgacat tttcgatgac cccgaatcgc cattttcaac cttcaacttc
     2221 cagtatccaa atcaagcatt caaaaggcta catgatctga tgtacttcaa cacactgaac
     2281 aacattgatg tgataaagga tgccattgtt gagagcattg aatacagaag acagaaccca
     2341 tctcgttgct ctgtttccct cagtaatgtt gaggcaagaa aattcttcaa caaggagttc
     2401 ctaagtaaac ccacagcaga gtccatttga attccatgac tactggagtt cagagcacat
     2461 gagagatcat cttactatgc acaagagact gactgctact cagagttgtg gggacggagg
     2521 cgtgtgttag gtgaaaatgg tgttgattat gcaatacttg gcaacagttt ctgacagtat
     2581 gaattttttg acataagcat agggctatat actgtatttt aaacattcct cacattttta
     2641 cctgagcatt tttatatata tataaaaata tcctttcctt ttataaatat ttaatagttt
     2701 aactcagtaa aaaaaagctt cccattgtgt gtgaatgtta ttctgaacta gatttgttca
     2761 tgccatgtta caacactatt tttatttaaa tgttcatatc tacacatgcg aaataaatac
     2821 tttgatatac aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_001437066            7136 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            4, mRNA.
ACCESSION   NM_001437066 XM_063277621
VERSION     NM_001437066.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.526075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000018.1  65218587-65218749
            164-255             JAXUCZ010000018.1  65219645-65219736
            256-328             JAXUCZ010000018.1  65221421-65221493
            329-390             JAXUCZ010000018.1  65334541-65334602
            391-487             JAXUCZ010000018.1  65337982-65338078
            488-549             JAXUCZ010000018.1  65391770-65391831
            550-679             JAXUCZ010000018.1  65437939-65438068
            680-729             JAXUCZ010000018.1  65438528-65438577
            730-835             JAXUCZ010000018.1  65507173-65507278
            836-966             JAXUCZ010000018.1  65511025-65511155
            967-1099            JAXUCZ010000018.1  65516916-65517048
            1100-1167           JAXUCZ010000018.1  65525175-65525242
            1168-1246           JAXUCZ010000018.1  65526319-65526397
            1247-1320           JAXUCZ010000018.1  65528844-65528917
            1321-1524           JAXUCZ010000018.1  65531547-65531750
            1525-1660           JAXUCZ010000018.1  65551334-65551469
            1661-1811           JAXUCZ010000018.1  65553405-65553555
            1812-2041           JAXUCZ010000018.1  65556812-65557041
            2042-2182           JAXUCZ010000018.1  65557878-65558018
            2183-7136           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7136
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..163
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            164..255
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2178
                     /gene="Tcf4"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 4"
                     /protein_id="NP_001423995.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDD
                     AIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGA
                     HREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSS
                     EIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMAN
                     NARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLN
                     PKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    424..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    424..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1846..2100
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1846..2100
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1870..1872,1882..1884,1888..1896,1900..1902,
                     1915..1917,1978..1983)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1870..1872,1882..1884,1888..1896,1900..1902,
                     1915..1917,1978..1983)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1909..1914,1921..1926,1930..1935,1942..1944,
                     1954..1956,1984..1986,1993..1995,2005..2007,2014..2016,
                     2023..2040)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1909..1914,1921..1926,1930..1935,1942..1944,
                     1954..1956,1984..1986,1993..1995,2005..2007,2014..2016,
                     2023..2040)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            256..328
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..390
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..679
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..729
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..835
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1099
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1167
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1320
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1524
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1660
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1811
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2041
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2182
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..7136
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcgg atcggcggcg gcggcggcgg cggcggcggg gaagccggag cgggcgcggg
       61 cgccggccgt tggaggaggt ggtggtggcg gaggcagggg gatagacatg accgccgcct
      121 gggcgccggc gctgcaccgg gagcccctcg tcgcgcgcgg gcggtttgtg tgattttgct
      181 aaaatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct gagtgattta
      241 ctggatttca gtgcgatgtt ttcgcctcct gtaagcagtg ggaaaaatgg accaacttct
      301 ttggcgagtg gacattttac gggctcaaat gtagaagaca gaagtagctc agggtcctgg
      361 gggaatggag gtcatccaag cccgtccagg aactatggag atgggactcc ctatgaccac
      421 atgactagca gggatcttgg gtcacatgac aatctctctc caccttttgt caattccaga
      481 atacaaagta aaacagaaag gggttcatac tcatcttatg ggagagaaaa cgtacagggt
      541 tgccaccagc agagtctcct cggaggggac atggatatgg gcaacccagg aaccctttcg
      601 cccaccaaac ctggctccca gtactaccca tattccagca ataacgcccg acggaggcct
      661 cttcacagta gtaccatgga ggtgcagaca aagaaagtca gaaaagttcc tccaggcttg
      721 ccatcttcag tctacgctcc ttcagccagc actgccgact acaacaggga ctcaccaggc
      781 tattcttcct ccaagccagc agccagcact ttctccagct ccttcttcat gcaagatggc
      841 catcacagca gtgacccttg gagctcctcc agtggaatga atcagcccgg ctatggaggg
      901 atgctaggca actctcatat cccacagtct agcagctact gtagcctgca tccacatgaa
      961 cgtctgagct atccatcgca ctcctcggca gacatcaact ccagtcttcc tccgatgtcc
     1021 acgttccatc gaagtggcac aaaccattac agcacctctt cctgcacacc tcctgccaac
     1081 ggaacagaca gtataatggc aaacagagga actggggcag caggcagctc ccagactgga
     1141 gacgctctgg ggaaagccct ggcttcgatc tattctcctg atcacacgaa caacagcttc
     1201 tcctccaacc cttcaactcc tgttggctcc cctccttcac tctcaggcac agctgtttgg
     1261 tctcgaaacg gaggacaggc ctcgtcatct cccaattacg aaggaccctt gcactccttg
     1321 cagagccgaa ttgaagaccg tttagaaaga ctggacgacg cgattcatgt tctccggaac
     1381 cacgcggtgg gcccatccac agctgtgccc ggtggccatg gggacatgca tgggatcatc
     1441 ggaccctctc acaatggagc aatgggcagt ctgggctcag gatatggaac tggccttctc
     1501 tcagccaaca gacattcact catggtcggg gcccaccgtg aagatggcgt ggcactgaga
     1561 ggcagccatt ctctcctgcc aaaccaggtt ccggttccac agcttccagt ccagtctgca
     1621 acttcccctg acttgaaccc accccaagac ccttacagag ggatgccacc aggcctccag
     1681 ggacagagtg tgtcttccgg cagctctgag atcaagtccg acgacgaggg cgatgagaac
     1741 ctacaggaca caaaatcttc cgaggacaag aaactagacg acgacaagaa ggatatcaaa
     1801 tcaattacta gcaataacga tgatgaggac ctgaccccgg agcagaaggc cgagcgtgag
     1861 aaggagcgga ggatggccaa taacgcccgt gagcgcctga gggtccgtga tatcaacgag
     1921 gctttcaagg agctgggccg catggtacag ctccacctga agagcgacaa gccccagacc
     1981 aagctcctga ttctccacca ggcagtggct gtcatcctca gcctggagca gcaagtgcga
     2041 gaaaggaacc tgaacccaaa agctgcctgt ctgaaaagaa gggaggaaga gaaggtgtcc
     2101 tcagagcctc ccccgctctc cttggctggc ccacaccctg ggatgggaga cgcagcgaat
     2161 cacatgggtc agatgtgaaa gggtccaagt tgccaccttg cttcattaaa acaagagacc
     2221 acttccttaa cagctgtatt atcctaaacc cacataaaca ctgctcctta accccgtttt
     2281 ttttgtaata taagacaagt ctgagtagtt atgaatcgca gacgcaagag gtttcagcat
     2341 tcccaattat caaaaaacag aaaaacaaac acaaaaaaaa aatgaatgaa agaaagaaag
     2401 aaagagaaaa tgcaacttga gggacgactt ctttaacata tcactctgaa tgtgcgaagc
     2461 ggtatgtaca ggctgagacg cagcccagag actgaatggc aatccttcca cactgtggag
     2521 caatgcattt gtgcctaaac ttcttttgga aaaaaaaata taattaattt gtaagtctga
     2581 aaaaaaatat ttaatttaaa aaaaattgta aacttgcaat aatgaaaaag tgtacttctg
     2641 aagaaaaacg acatgaacgt ttttgttggt attcaagtca gctagtgttt ctaattaccg
     2701 gatattgaat agaggaagcc cggctaccct cataacaaaa ccagcaaccg tcctgatggc
     2761 aaccgaaatg atgacattag ccattcctta gggtaggagg gacagatgga tgttatagac
     2821 ctatgacaaa tatatatata aatatatata taaatatata ttaaaaattt agtgactatg
     2881 gtaagctttt gttcatttgt ttcagacttt tttctcctgt aaaaaaatag tactgattaa
     2941 cttttttaaa agaaagattt tactgtaaat atggattttt ttttgtctga tttttgtccc
     3001 ttcccccagt ttgttatcgt gacctgtagt gccaactctg cttccggagg ggcagtgcag
     3061 gacgaaatgc tgaccctgat gttgcttctc attcataaat agtagaaagt tgtttctcca
     3121 gtcttttggg aacacaggac ttaaaagtca catcatgtgt agaaattaca tgcagcattg
     3181 cccgggcaag gcaaaaagag tttgtctggc ttgtggcact gtgcttgtta ccctctcctg
     3241 ggattttcag aggtacacgg ttagaatgct acaatgttac cactgtgcct tccaatgttt
     3301 atatcatcgg aaacatgaca taatcaaagt ggctgtgatt taacaaaaaa aaaaaaagat
     3361 tcaagtgtta cctacctgtg tagcggaagt agtgtgcagt gagacgtttc tgaatacatg
     3421 gtcagatttt ttttggaaaa aatacaaaaa caaaaaaaaa aaacaaaaaa atttaaaaaa
     3481 aaaagtcaag ttcaaaaacc gtcaaatgag aaaatcgcaa ggagtgtgac agctgattga
     3541 ttttgttgct tttcttgatt tttttttttt tgtttccaaa tgggtttact aaaaagtaca
     3601 tgacttacct gcctcctcct tcgtctgaaa acaaaaaaca aaaaaacaat gccaacctat
     3661 cccacagcat tatagcaagc cttataagcc ctaaagcatt aagttgcact ttggtgagga
     3721 ggggtagcgc agtattctct ctggccagta tgagtgaagt ttatacttaa catttgatag
     3781 aaacatagat caaactgtgg cacagtaact catcagatag ctagcgttga ctctgggcac
     3841 aattgaacca attcccatcc taaatctttc caacaattga ctttggtgta cagtgcagtg
     3901 aacacataga actcctactt aagtattcgt cagcatcctt ttgtctctaa ctcggttctg
     3961 ttttgacagc cacacaatct tggcatgtat taagtaaaaa aaaaaaaaaa atccctgttg
     4021 aagtagtttt cccacctatc agcactgagt aattgccgta actcaatgga aatggtctaa
     4081 acgcccccca tctcttgtcc tgtaccacca gttacacagt gacaaaacac atctgtaaat
     4141 tttatgcaac caatggcaaa cctatcatta ttttgaaact gtgtatgtaa aagttatatt
     4201 tttacatgta gactcttgtt attatgtgtt ttaatacatt gtatcagttt tttgtttcct
     4261 ttttttttta actgtgtggt tttaaaaagt catttaaatg aaatagcgag ctacaagaat
     4321 ctgaaattta tgttcatttc tgaaaatgta agaacaaata agatagttat cacgtggtca
     4381 ccttttacaa acccatcgat gttttgacta gctgtgtgta tgtgtgtgtg tgcgcatgtg
     4441 tgcgtgtgtg tgtatgtgtg ttgaaaactg taaatatgtt cagtagcgat aaaacgacaa
     4501 tgctttgatt tgttgagaag ttcctaaaat gtggaggtgg attgaaaatg taggggaata
     4561 gcagaaatca gatttcatga agagctcttc tcttcggggg ctttcctgtg gaatggtcaa
     4621 acagaggtgc tccaagaagg gcaaggaaga cagtaacttc ccctcctccc tgaacgacgg
     4681 aaaccatgtg tacgtggtct ctcaccatgt taaagatttt ctttccgtga tacattctgc
     4741 actctttttg tatagtctac caaggcgggt atccctggga acaatattat gatataggaa
     4801 gcagtatact ctgatcacat tcaggagaat tgtatagaag agaatatggt gtttactctt
     4861 tagggaactg gaaattctcc ctgcattgat gtacatcttc agagcggccc ttttgataca
     4921 cgttatcata aaggtgctga ctaaagcaga attaaagttt ttcaaatctg taaacaaagc
     4981 aaaaaattaa attacagtca ttcgattgtt tgtttttttt tttttccaat tggtgctttt
     5041 atattttgtt ctcactcaga cagaaaaggc tgcaatttct tgttcaccag ctttgatgta
     5101 ttcattactc ggtaatgtaa tacggctatt gtcaaattcc ttttggaaat aagcaaaagg
     5161 cttccccaag gcctgcagca gctgctggct actttctgct tggcgcagaa acatgatctg
     5221 accctctctg tagtaatcga gttgtatctc cagttttaaa aagaaggaaa aagggaatgt
     5281 ggccgtttta atgtgttttt ttttttcttt tcttgttgtt attttgtaat tctcaaaccc
     5341 aggtaagata ttggtattcc tgcactggat ttttgaaaga aacttagcag aagacaggat
     5401 cgagatacta tagaagcatt tcccaagtgt tcatactata ctagacataa atgataacgg
     5461 cgatgtatag gttcaggatc ggtttaagag actcagactt tgaaagcaac ttggaacggt
     5521 tgatccacct ccacattcga gtaattaata attctgcaga attagggatc tgtccatcta
     5581 ggagttgtta cccatttgtc ttctgtgtgg ctgcgaggaa cactaacgct tttacaactg
     5641 tcagttcacc cagtggtaca actgattctg actcagtctt ccgattcctg ttttgtattt
     5701 tgtttttcca cttttttcct atctcttgat tttattgttg ttgttattgc tattgttatt
     5761 attattattc gtgatcttta tttcgatgag gggttgggaa gtgggaggga gtcgaactga
     5821 gactaggggt tgagaggatt tttttggttt ggttttcttt tctttttttt ttgttttttt
     5881 ttttttttgt ttgtttgttt catctttgcg tccaacaggc agaatatggt ctgtgtccaa
     5941 aacggaactt aagtcaggaa ggaaaccatt cagcgtaaac aagcacaaca tgtagtctgt
     6001 cggctgtctg gaagcaaaaa taaattaata aataaataat aaataagtaa aagacacaca
     6061 cggaggtgaa gatgaaatgt gatggattcc gagacaatgg ggcaccaagg cctgtaggcc
     6121 tcctcttgat tttgctttgg ttatgtttgt tttccttaga gatgtttttt tcctcacggg
     6181 acttgaagtg actcatctct gtgcagtaat ggtttcgcca tatgctcatt tcaagtatta
     6241 tagacatatg taatggtgaa atatatgaac tgtggccttt ttcattcttg ttatttgtga
     6301 tgcaattaag tgaagagaag aaaaaaaaaa gcagagattt accatgtatc agtgcctggc
     6361 tttttgttat aaagcttcgt ctgtctagtg ctctttttgc tataaaaata gactgtagta
     6421 caccctagta ggaaaaaaaa accctaaatt taaaaataaa aaaatatatt tggcttattt
     6481 ttcgcaggag caatcctttt ataccatgga tattacaaaa aaaaaaattg tcagattctg
     6541 aatatttctt ctttgtagat ttttggaatc attataagta aaagtttgtt actttatttt
     6601 actatttaaa agatgttatt ttgccatgtg ttactgagat gaaactgtat ggtatagctt
     6661 cttctgttcg ttttttgttt ccggtttttt gtttgttcgt ttttggtttt tttttttttt
     6721 gtttgtttgt tttgttttgt ttttttttct tagttgtagg tcgcagtaag gacttttcct
     6781 tttgtttttg ttttttcgtt atgttttgtt ttgtttttgc gactgtacac atagctgcag
     6841 cattaaaaac ttttaaaaaa atctgttaaa aaaaaaagaa aaaaaaggga aaacgtttaa
     6901 aaaaaaaaga taaacagtta caccttgttt tcaacgtgtg gctgagtgcc tcgatttttt
     6961 catgtttttg gtgtatttct gatttgtaga agtgtccaaa caggttgtgt cctggacttc
     7021 cttcaagagg cgaacaaccc agcttggtct aggccatgac ctgttcccat ctgtagttac
     7081 tcgatgaagt catgtacatg accgttctgt agcaataaat gtgccatttt tataaa
//
LOCUS       NM_001437084            5078 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 10, mRNA.
ACCESSION   NM_001437084 XM_063288051
VERSION     NM_001437084.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5078)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5078)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5078)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5078)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5078)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5078)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5078)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5078)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5078)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5078)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288051.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16354.1,
                                           SRR26643292.23340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1467           JAXUCZ010000005.1  148197680-148197781
            1468-1619           JAXUCZ010000005.1  148200975-148201126
            1620-1758           JAXUCZ010000005.1  148203568-148203706
            1759-1902           JAXUCZ010000005.1  148205552-148205695
            1903-2199           JAXUCZ010000005.1  148206678-148206974
            2200-2467           JAXUCZ010000005.1  148218465-148218732
            2468-2597           JAXUCZ010000005.1  148219783-148219912
            2598-2726           JAXUCZ010000005.1  148221617-148221745
            2727-2864           JAXUCZ010000005.1  148225153-148225290
            2865-2990           JAXUCZ010000005.1  148228732-148228857
            2991-3112           JAXUCZ010000005.1  148229514-148229635
            3113-3305           JAXUCZ010000005.1  148231206-148231398
            3306-5078           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5078
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3437
                     /gene="Pum1"
                     /note="isoform 10 is encoded by transcript variant 10;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 10"
                     /protein_id="NP_001424013.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAAT
                     LGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGA
                     SQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALV
                     VNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLG
                     TQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLG
                     ATLGSALGGFGTAGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRY
                     GMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAE
                     RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGC
                     RVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAF
                     KGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLE
                     HGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPH
                     SALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKY
                     YMKNGVDLGPICGPPNGII"
     misc_feature    2403..3368
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2403..3368
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2571..2576,2583..2585,2679..2684,2691..2693,
                     2790..2792,2799..2801,2895..2900,2907..2909,2994..2999,
                     3003..3008,3015..3017,3102..3107,3111..3116,3123..3125,
                     3231..3236,3240..3245,3252..3254,3342..3344,3351..3353)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2571..2576,2583..2585,2679..2684,2691..2693,
                     2790..2792,2799..2801,2895..2900,2907..2909,2994..2999,
                     3003..3008,3015..3017,3102..3107,3111..3116,3123..3125,
                     3231..3236,3240..3245,3252..3254,3342..3344,3351..3353)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1619
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1758
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1902
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2199
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2597
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2726
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2864
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2990
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3112
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3305
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..5078
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggttta gctcccgctg
     1381 cgtttgtccc caacccatac atcatcagcg ctgctccccc agggacggac ccctacacag
     1441 ctggattggc tgcagcagcg acactcggcc cagctgtggt ccctcaccaa tattatggag
     1501 tcacgccatg gggtgtctat cctgctagtc ttttccagca acaagctgct gcagctgcag
     1561 cagcaacaaa ttcagctact cagcagagtg ccccacaggc ccagcaggga cagcagcagg
     1621 ttcttcgtgg aggagctagc cagcgtcctt tgaccccaaa tcagaaccag cagggacaac
     1681 aaacagatcc ccttgtagca gctgcagcag tgaactctgc tcttgccttt ggacaaggat
     1741 tggctgcagg tatgccaggt tatccagtct tggcacctgc tgcttactat gaccaaactg
     1801 gtgcccttgt ggtgaatgca ggggcaagaa atggcctcgg agctccagtt cggcttgttg
     1861 ctccagcccc agtcatcatt agctcctcag ctgcacaagc agctgttgca gcggctgcag
     1921 cttcagcaaa tggagcagcc ggtggtcttg caggaactac aaatggacca tttcgacctt
     1981 taggcaccca gcagccccag ccccagcccc agcagcagcc cagtaacaat ctggcttcca
     2041 gctctttcta tggcaacaac tctctgagca gtaactccca gagcagctcc ctcttctctc
     2101 agggctccgc ccagcctgcc aacacgtcct tgggattcgg aagcagcagt tcccttggtg
     2161 ccaccctagg atcggccctt ggagggtttg gaacagcagg aggactcacg aacggcagtg
     2221 gaagatacat ctctgctgct cctggtgccg aagccaagta ccgcagtgcg agcagtgcct
     2281 ccagcctttt cagccccagc agcacccttt tttcttcctc tcgtttgaga tacggaatgt
     2341 ctgatgttat gccctctggc aggagcagac ttctggaaga ctttcgaaac aaccggtacc
     2401 ctaatttaca actgcgggag attgccgggc atataatgga attttcccaa gaccagcatg
     2461 gttctagatt cattcagctg aaactagagc gagccacagc agctgagcgc cagcttgtct
     2521 tcaacgaaat cctgcaggct gcgtaccaac ttatggtgga tgtgtttgga aattacgtca
     2581 ttcagaagtt ctttgaattt ggcagccatg aacagaagct ggctttggct gaacggattc
     2641 gaggccacgt cctatcattg gcactgcaga tgtatggctg ccgagtcatc cagaaagctt
     2701 tggaatttat tccctcagac cagcagaacg agatggtgcg ggagctagat ggccatgtcc
     2761 tgaagtgtgt gaaagaccag aatggcaacc atgtggttca gaagtgcatt gaatgtgtac
     2821 agccccagtc tttgcagttc atcatcgatg cattcaaggg gcaggtgttt gctttgtcta
     2881 cgcacccata tggctgtagg gtgatccaga ggatcctgga acactgtctc cccgaccaga
     2941 ccctccctat cctggaggag cttcaccagc acacggagca gctcgtgcag gatcagtatg
     3001 gaaattatgt aatccaacat gtcctggagc atggtcgtcc tgaggataaa agcaaaattg
     3061 tagcagagat ccgaggcaat gtacttgtat tgagtcagca caaattcgca agcaatgttg
     3121 tggagaagtg tgtcactcac gcctcacgta cagagcgtgc tgtgctcatt gatgaggtat
     3181 gcaccatgaa tgacggtccc cacagtgcct tatacaccat gatgaaggat cagtatgcca
     3241 attatgtggt ccagaagatg atcgatgtgg ctgagccggg gcagcggaag attgtcatgc
     3301 acaagatccg gccacacatc gcgactcttc ggaagtacac ctatggcaag cacatcctgg
     3361 ccaagcttga gaagtactac atgaagaatg gtgtggactt ggggcccatt tgtggtcccc
     3421 ctaatgggat catctgagca gtgcacccat ccctgtcccg ctgacctcac tgaccctggc
     3481 agatccaacc agcaaccaga gatgcccagc tcagagtcga aagtgggcga tggttgctcc
     3541 gggattgctc cctcctccaa aaatggaatc ggatccactt gtggaaaggc ctttgtaaat
     3601 ttcattttat tacacataac atgtactaat tatttttttt aattgactaa ttgccctgct
     3661 gtttactggt gtataggaac ttgtacatag gtaatcagtg tacatgagag gccacatgct
     3721 ttgttcaatg ttgtatctat attccacatg tggacacttt cagggtggtt ggtttaacaa
     3781 aaaaagtttt aaaaaaagac aaaaaaaggt ttttaactca tttgccttgt ggcaagtttt
     3841 gcaaatagct cttccccacc ccattttatt aaaaaaagaa acctgagaaa tttgaatttt
     3901 agttaaataa tctcaaactg gcatttaaca ctgtttataa aatatatata tatatataca
     3961 tatatacata tgaaatggga acgtttccga gttgctaaag catcagcctg tgatacggag
     4021 tttatgacgc tctttggaga tgacctcatg ctgagggagg tggtagctgc agatccagga
     4081 ggagcgggaa gcacagagac aggccggagg ccagtgggca tggccacttg ctctatgggt
     4141 tgccttctgt gaacactggg aagcagaatc tgattatcta gcatgagaga acccagctct
     4201 gctcctggtc tggcttctat agatacatag tgtatacttg tgtagacttt gcatatatac
     4261 ggatttgtag tattttcctg ttttgatgtc taatctgtat ctataatgta ccctagtagt
     4321 cggacatact tttgattgta caattgtaca tttgtatacc tgtaatgtaa atgtggagaa
     4381 gtttgaatca acatgaacac gtttttggta agaagagaac cggccagccc gtgcactctg
     4441 tatatcccac cttttatggt tgtagcagat agtgttgtat attgtaaatt gtaatttcaa
     4501 acagaagtaa atttttttct tttgaaggaa taaatgttct ttatacagcc tagttaatgt
     4561 ttaaaaagaa aaaatagctt ggtttatttg tcagctagtc aagacggtag tgagagcctt
     4621 tctaaatgtt acttcagatg attcagttca cactagtgtt cctttttttt tttttatcct
     4681 aagaaaaggt aatgtttcgc ttattttgtg acagtcaaaa ggatgtgcag aagtttcgcc
     4741 tgccccttcc ctgctcacca cctccccttg taaagtgact caccctccgt tttgtacaga
     4801 tgagctgtat tttgcatttt gtctacttgt aagtgaatgt aacatactgt caatcctcgt
     4861 ttgaatatag actgtaacac tacacggtgt acatttccag agccttgtgt atatttccaa
     4921 tgaacttttt gcaagcacac ttgtaaccat atgtgtataa ttaacaaacc tgtgtatgct
     4981 tatgcctggg caactatttt ttgtaactct tgtgtagatt gtctctaaac aatgtgtgat
     5041 ctttattttg aaaaaaatac agaactttgg aatctgaa
//
LOCUS       NM_001437099            7266 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            23, mRNA.
ACCESSION   NM_001437099 XM_039097157
VERSION     NM_001437099.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7266)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7266)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7266)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7266)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7266)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7266)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7266)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7266)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7266)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7266)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097157.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.63244.1,
                                           SRR26643298.74595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000018.1  65218060-65218337
            279-370             JAXUCZ010000018.1  65219645-65219736
            371-443             JAXUCZ010000018.1  65221421-65221493
            444-505             JAXUCZ010000018.1  65334541-65334602
            506-602             JAXUCZ010000018.1  65337982-65338078
            603-664             JAXUCZ010000018.1  65391770-65391831
            665-794             JAXUCZ010000018.1  65437939-65438068
            795-844             JAXUCZ010000018.1  65438528-65438577
            845-950             JAXUCZ010000018.1  65507173-65507278
            951-1081            JAXUCZ010000018.1  65511025-65511155
            1082-1214           JAXUCZ010000018.1  65516916-65517048
            1215-1282           JAXUCZ010000018.1  65525175-65525242
            1283-1361           JAXUCZ010000018.1  65526319-65526397
            1362-1438           JAXUCZ010000018.1  65528841-65528917
            1439-1642           JAXUCZ010000018.1  65531547-65531750
            1643-1778           JAXUCZ010000018.1  65551334-65551469
            1779-1941           JAXUCZ010000018.1  65553405-65553567
            1942-2171           JAXUCZ010000018.1  65556812-65557041
            2172-2312           JAXUCZ010000018.1  65557878-65558018
            2313-7266           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7266
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            279..370
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2308
                     /gene="Tcf4"
                     /note="isoform 21 is encoded by transcript variant 23;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 21"
                     /protein_id="NP_001424028.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLD
                     DAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVG
                     AHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS
                     SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKE
                     RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR
                     ERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    701..>1186
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    701..>1186
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1976..2230
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1976..2230
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2000..2002,2012..2014,2018..2026,2030..2032,
                     2045..2047,2108..2113)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2000..2002,2012..2014,2018..2026,2030..2032,
                     2045..2047,2108..2113)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2039..2044,2051..2056,2060..2065,2072..2074,
                     2084..2086,2114..2116,2123..2125,2135..2137,2144..2146,
                     2153..2170)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2039..2044,2051..2056,2060..2065,2072..2074,
                     2084..2086,2114..2116,2123..2125,2135..2137,2144..2146,
                     2153..2170)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            371..443
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..505
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            506..602
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..664
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            665..794
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            795..844
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            845..950
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1081
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1214
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1282
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1361
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1438
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1642
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1778
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1941
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2171
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2312
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..7266
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaaagcaa aacttgcttt gcagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
       61 tgtgtgtgtg tgagagagag agagagagag agagagagag agagagagag agttacagag
      121 acagacagag agacagacag aagtgagagg ggatgtaaac tcgaatcaat ttcaaagtgc
      181 ctccggtgga tgaacccggc aaatcctcaa ctgttcaggc ttcagattgt aactggcgat
      241 ctgaggggga aaatgaggtg ctgggtgaat tttccttggt ttgtgtgatt ttgctaaaat
      301 gcatcaccaa cagcgaatgg ctgccttagg gacggacaaa gagctgagtg atttactgga
      361 tttcagtgcg atgttttcgc ctcctgtaag cagtgggaaa aatggaccaa cttctttggc
      421 gagtggacat tttacgggct caaatgtaga agacagaagt agctcagggt cctgggggaa
      481 tggaggtcat ccaagcccgt ccaggaacta tggagatggg actccctatg accacatgac
      541 tagcagggat cttgggtcac atgacaatct ctctccacct tttgtcaatt ccagaataca
      601 aagtaaaaca gaaaggggtt catactcatc ttatgggaga gaaaacgtac agggttgcca
      661 ccagcagagt ctcctcggag gggacatgga tatgggcaac ccaggaaccc tttcgcccac
      721 caaacctggc tcccagtact acccatattc cagcaataac gcccgacgga ggcctcttca
      781 cagtagtacc atggaggtgc agacaaagaa agtcagaaaa gttcctccag gcttgccatc
      841 ttcagtctac gctccttcag ccagcactgc cgactacaac agggactcac caggctattc
      901 ttcctccaag ccagcagcca gcactttctc cagctccttc ttcatgcaag atggccatca
      961 cagcagtgac ccttggagct cctccagtgg aatgaatcag cccggctatg gagggatgct
     1021 aggcaactct catatcccac agtctagcag ctactgtagc ctgcatccac atgaacgtct
     1081 gagctatcca tcgcactcct cggcagacat caactccagt cttcctccga tgtccacgtt
     1141 ccatcgaagt ggcacaaacc attacagcac ctcttcctgc acacctcctg ccaacggaac
     1201 agacagtata atggcaaaca gaggaactgg ggcagcaggc agctcccaga ctggagacgc
     1261 tctggggaaa gccctggctt cgatctattc tcctgatcac acgaacaaca gcttctcctc
     1321 caacccttca actcctgttg gctcccctcc ttcactctca gcaggcacag ctgtttggtc
     1381 tcgaaacgga ggacaggcct cgtcatctcc caattacgaa ggacccttgc actccttgca
     1441 gagccgaatt gaagaccgtt tagaaagact ggacgacgcg attcatgttc tccggaacca
     1501 cgcggtgggc ccatccacag ctgtgcccgg tggccatggg gacatgcatg ggatcatcgg
     1561 accctctcac aatggagcaa tgggcagtct gggctcagga tatggaactg gccttctctc
     1621 agccaacaga cattcactca tggtcggggc ccaccgtgaa gatggcgtgg cactgagagg
     1681 cagccattct ctcctgccaa accaggttcc ggttccacag cttccagtcc agtctgcaac
     1741 ttcccctgac ttgaacccac cccaagaccc ttacagaggg atgccaccag gcctccaggg
     1801 acagagtgtg tcttccggca gctctgagat caagtccgac gacgagggcg atgagaacct
     1861 acaggacaca aaatcttccg aggacaagaa actagacgac gacaagaagg atatcaaatc
     1921 aattactagg tcaagatcta gcaataacga tgatgaggac ctgaccccgg agcagaaggc
     1981 cgagcgtgag aaggagcgga ggatggccaa taacgcccgt gagcgcctga gggtccgtga
     2041 tatcaacgag gctttcaagg agctgggccg catggtacag ctccacctga agagcgacaa
     2101 gccccagacc aagctcctga ttctccacca ggcagtggct gtcatcctca gcctggagca
     2161 gcaagtgcga gaaaggaacc tgaacccaaa agctgcctgt ctgaaaagaa gggaggaaga
     2221 gaaggtgtcc tcagagcctc ccccgctctc cttggctggc ccacaccctg ggatgggaga
     2281 cgcagcgaat cacatgggtc agatgtgaaa gggtccaagt tgccaccttg cttcattaaa
     2341 acaagagacc acttccttaa cagctgtatt atcctaaacc cacataaaca ctgctcctta
     2401 accccgtttt ttttgtaata taagacaagt ctgagtagtt atgaatcgca gacgcaagag
     2461 gtttcagcat tcccaattat caaaaaacag aaaaacaaac acaaaaaaaa aatgaatgaa
     2521 agaaagaaag aaagagaaaa tgcaacttga gggacgactt ctttaacata tcactctgaa
     2581 tgtgcgaagc ggtatgtaca ggctgagacg cagcccagag actgaatggc aatccttcca
     2641 cactgtggag caatgcattt gtgcctaaac ttcttttgga aaaaaaaata taattaattt
     2701 gtaagtctga aaaaaaatat ttaatttaaa aaaaattgta aacttgcaat aatgaaaaag
     2761 tgtacttctg aagaaaaacg acatgaacgt ttttgttggt attcaagtca gctagtgttt
     2821 ctaattaccg gatattgaat agaggaagcc cggctaccct cataacaaaa ccagcaaccg
     2881 tcctgatggc aaccgaaatg atgacattag ccattcctta gggtaggagg gacagatgga
     2941 tgttatagac ctatgacaaa tatatatata aatatatata taaatatata ttaaaaattt
     3001 agtgactatg gtaagctttt gttcatttgt ttcagacttt tttctcctgt aaaaaaatag
     3061 tactgattaa cttttttaaa agaaagattt tactgtaaat atggattttt ttttgtctga
     3121 tttttgtccc ttcccccagt ttgttatcgt gacctgtagt gccaactctg cttccggagg
     3181 ggcagtgcag gacgaaatgc tgaccctgat gttgcttctc attcataaat agtagaaagt
     3241 tgtttctcca gtcttttggg aacacaggac ttaaaagtca catcatgtgt agaaattaca
     3301 tgcagcattg cccgggcaag gcaaaaagag tttgtctggc ttgtggcact gtgcttgtta
     3361 ccctctcctg ggattttcag aggtacacgg ttagaatgct acaatgttac cactgtgcct
     3421 tccaatgttt atatcatcgg aaacatgaca taatcaaagt ggctgtgatt taacaaaaaa
     3481 aaaaaaagat tcaagtgtta cctacctgtg tagcggaagt agtgtgcagt gagacgtttc
     3541 tgaatacatg gtcagatttt ttttggaaaa aatacaaaaa caaaaaaaaa aaacaaaaaa
     3601 atttaaaaaa aaaagtcaag ttcaaaaacc gtcaaatgag aaaatcgcaa ggagtgtgac
     3661 agctgattga ttttgttgct tttcttgatt tttttttttt tgtttccaaa tgggtttact
     3721 aaaaagtaca tgacttacct gcctcctcct tcgtctgaaa acaaaaaaca aaaaaacaat
     3781 gccaacctat cccacagcat tatagcaagc cttataagcc ctaaagcatt aagttgcact
     3841 ttggtgagga ggggtagcgc agtattctct ctggccagta tgagtgaagt ttatacttaa
     3901 catttgatag aaacatagat caaactgtgg cacagtaact catcagatag ctagcgttga
     3961 ctctgggcac aattgaacca attcccatcc taaatctttc caacaattga ctttggtgta
     4021 cagtgcagtg aacacataga actcctactt aagtattcgt cagcatcctt ttgtctctaa
     4081 ctcggttctg ttttgacagc cacacaatct tggcatgtat taagtaaaaa aaaaaaaaaa
     4141 atccctgttg aagtagtttt cccacctatc agcactgagt aattgccgta actcaatgga
     4201 aatggtctaa acgcccccca tctcttgtcc tgtaccacca gttacacagt gacaaaacac
     4261 atctgtaaat tttatgcaac caatggcaaa cctatcatta ttttgaaact gtgtatgtaa
     4321 aagttatatt tttacatgta gactcttgtt attatgtgtt ttaatacatt gtatcagttt
     4381 tttgtttcct ttttttttta actgtgtggt tttaaaaagt catttaaatg aaatagcgag
     4441 ctacaagaat ctgaaattta tgttcatttc tgaaaatgta agaacaaata agatagttat
     4501 cacgtggtca ccttttacaa acccatcgat gttttgacta gctgtgtgta tgtgtgtgtg
     4561 tgcgcatgtg tgcgtgtgtg tgtatgtgtg ttgaaaactg taaatatgtt cagtagcgat
     4621 aaaacgacaa tgctttgatt tgttgagaag ttcctaaaat gtggaggtgg attgaaaatg
     4681 taggggaata gcagaaatca gatttcatga agagctcttc tcttcggggg ctttcctgtg
     4741 gaatggtcaa acagaggtgc tccaagaagg gcaaggaaga cagtaacttc ccctcctccc
     4801 tgaacgacgg aaaccatgtg tacgtggtct ctcaccatgt taaagatttt ctttccgtga
     4861 tacattctgc actctttttg tatagtctac caaggcgggt atccctggga acaatattat
     4921 gatataggaa gcagtatact ctgatcacat tcaggagaat tgtatagaag agaatatggt
     4981 gtttactctt tagggaactg gaaattctcc ctgcattgat gtacatcttc agagcggccc
     5041 ttttgataca cgttatcata aaggtgctga ctaaagcaga attaaagttt ttcaaatctg
     5101 taaacaaagc aaaaaattaa attacagtca ttcgattgtt tgtttttttt tttttccaat
     5161 tggtgctttt atattttgtt ctcactcaga cagaaaaggc tgcaatttct tgttcaccag
     5221 ctttgatgta ttcattactc ggtaatgtaa tacggctatt gtcaaattcc ttttggaaat
     5281 aagcaaaagg cttccccaag gcctgcagca gctgctggct actttctgct tggcgcagaa
     5341 acatgatctg accctctctg tagtaatcga gttgtatctc cagttttaaa aagaaggaaa
     5401 aagggaatgt ggccgtttta atgtgttttt ttttttcttt tcttgttgtt attttgtaat
     5461 tctcaaaccc aggtaagata ttggtattcc tgcactggat ttttgaaaga aacttagcag
     5521 aagacaggat cgagatacta tagaagcatt tcccaagtgt tcatactata ctagacataa
     5581 atgataacgg cgatgtatag gttcaggatc ggtttaagag actcagactt tgaaagcaac
     5641 ttggaacggt tgatccacct ccacattcga gtaattaata attctgcaga attagggatc
     5701 tgtccatcta ggagttgtta cccatttgtc ttctgtgtgg ctgcgaggaa cactaacgct
     5761 tttacaactg tcagttcacc cagtggtaca actgattctg actcagtctt ccgattcctg
     5821 ttttgtattt tgtttttcca cttttttcct atctcttgat tttattgttg ttgttattgc
     5881 tattgttatt attattattc gtgatcttta tttcgatgag gggttgggaa gtgggaggga
     5941 gtcgaactga gactaggggt tgagaggatt tttttggttt ggttttcttt tctttttttt
     6001 ttgttttttt ttttttttgt ttgtttgttt catctttgcg tccaacaggc agaatatggt
     6061 ctgtgtccaa aacggaactt aagtcaggaa ggaaaccatt cagcgtaaac aagcacaaca
     6121 tgtagtctgt cggctgtctg gaagcaaaaa taaattaata aataaataat aaataagtaa
     6181 aagacacaca cggaggtgaa gatgaaatgt gatggattcc gagacaatgg ggcaccaagg
     6241 cctgtaggcc tcctcttgat tttgctttgg ttatgtttgt tttccttaga gatgtttttt
     6301 tcctcacggg acttgaagtg actcatctct gtgcagtaat ggtttcgcca tatgctcatt
     6361 tcaagtatta tagacatatg taatggtgaa atatatgaac tgtggccttt ttcattcttg
     6421 ttatttgtga tgcaattaag tgaagagaag aaaaaaaaaa gcagagattt accatgtatc
     6481 agtgcctggc tttttgttat aaagcttcgt ctgtctagtg ctctttttgc tataaaaata
     6541 gactgtagta caccctagta ggaaaaaaaa accctaaatt taaaaataaa aaaatatatt
     6601 tggcttattt ttcgcaggag caatcctttt ataccatgga tattacaaaa aaaaaaattg
     6661 tcagattctg aatatttctt ctttgtagat ttttggaatc attataagta aaagtttgtt
     6721 actttatttt actatttaaa agatgttatt ttgccatgtg ttactgagat gaaactgtat
     6781 ggtatagctt cttctgttcg ttttttgttt ccggtttttt gtttgttcgt ttttggtttt
     6841 tttttttttt gtttgtttgt tttgttttgt ttttttttct tagttgtagg tcgcagtaag
     6901 gacttttcct tttgtttttg ttttttcgtt atgttttgtt ttgtttttgc gactgtacac
     6961 atagctgcag cattaaaaac ttttaaaaaa atctgttaaa aaaaaaagaa aaaaaaggga
     7021 aaacgtttaa aaaaaaaaga taaacagtta caccttgttt tcaacgtgtg gctgagtgcc
     7081 tcgatttttt catgtttttg gtgtatttct gatttgtaga agtgtccaaa caggttgtgt
     7141 cctggacttc cttcaagagg cgaacaaccc agcttggtct aggccatgac ctgttcccat
     7201 ctgtagttac tcgatgaagt catgtacatg accgttctgt agcaataaat gtgccatttt
     7261 tataaa
//
LOCUS       NM_001437100            7455 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            24, mRNA.
ACCESSION   NM_001437100 XM_039097169
VERSION     NM_001437100.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097169.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74593.1,
                                           SRR26643299.63243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-632             JAXUCZ010000018.1  65221421-65221493
            633-694             JAXUCZ010000018.1  65334541-65334602
            695-791             JAXUCZ010000018.1  65337982-65338078
            792-853             JAXUCZ010000018.1  65391770-65391831
            854-983             JAXUCZ010000018.1  65437939-65438068
            984-1033            JAXUCZ010000018.1  65438528-65438577
            1034-1139           JAXUCZ010000018.1  65507173-65507278
            1140-1270           JAXUCZ010000018.1  65511025-65511155
            1271-1403           JAXUCZ010000018.1  65516916-65517048
            1404-1471           JAXUCZ010000018.1  65525175-65525242
            1472-1550           JAXUCZ010000018.1  65526319-65526397
            1551-1627           JAXUCZ010000018.1  65528841-65528917
            1628-1831           JAXUCZ010000018.1  65531547-65531750
            1832-1967           JAXUCZ010000018.1  65551334-65551469
            1968-2130           JAXUCZ010000018.1  65553405-65553567
            2131-2360           JAXUCZ010000018.1  65556812-65557041
            2361-2501           JAXUCZ010000018.1  65557878-65558018
            2502-7455           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7455
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    536..538
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             560..2497
                     /gene="Tcf4"
                     /note="isoform 22 is encoded by transcript variant 24;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 22"
                     /protein_id="NP_001424029.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLL
                     GGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVY
                     APSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLG
                     NSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANG
                     TDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA
                     VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDM
                     HGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQ
                     LPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKL
                     DDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELG
                     RMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPP
                     PLSLAGPHPGMGDAANHMGQM"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2165..2419
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2165..2419
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2189..2191,2201..2203,2207..2215,2219..2221,
                     2234..2236,2297..2302)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2189..2191,2201..2203,2207..2215,2219..2221,
                     2234..2236,2297..2302)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2228..2233,2240..2245,2249..2254,2261..2263,
                     2273..2275,2303..2305,2312..2314,2324..2326,2333..2335,
                     2342..2359)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2228..2233,2240..2245,2249..2254,2261..2263,
                     2273..2275,2303..2305,2312..2314,2324..2326,2333..2335,
                     2342..2359)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            560..632
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..694
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..791
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..853
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..983
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1033
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1139
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1270
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1403
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1471
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1550
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1627
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1831
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2130
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2360
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2501
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..7455
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaaga tgttttcgcc tcctgtaagc agtgggaaaa atggaccaac
      601 ttctttggcg agtggacatt ttacgggctc aaatgtagaa gacagaagta gctcagggtc
      661 ctgggggaat ggaggtcatc caagcccgtc caggaactat ggagatggga ctccctatga
      721 ccacatgact agcagggatc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc
      781 cagaatacaa agtaaaacag aaaggggttc atactcatct tatgggagag aaaacgtaca
      841 gggttgccac cagcagagtc tcctcggagg ggacatggat atgggcaacc caggaaccct
      901 ttcgcccacc aaacctggct cccagtacta cccatattcc agcaataacg cccgacggag
      961 gcctcttcac agtagtacca tggaggtgca gacaaagaaa gtcagaaaag ttcctccagg
     1021 cttgccatct tcagtctacg ctccttcagc cagcactgcc gactacaaca gggactcacc
     1081 aggctattct tcctccaagc cagcagccag cactttctcc agctccttct tcatgcaaga
     1141 tggccatcac agcagtgacc cttggagctc ctccagtgga atgaatcagc ccggctatgg
     1201 agggatgcta ggcaactctc atatcccaca gtctagcagc tactgtagcc tgcatccaca
     1261 tgaacgtctg agctatccat cgcactcctc ggcagacatc aactccagtc ttcctccgat
     1321 gtccacgttc catcgaagtg gcacaaacca ttacagcacc tcttcctgca cacctcctgc
     1381 caacggaaca gacagtataa tggcaaacag aggaactggg gcagcaggca gctcccagac
     1441 tggagacgct ctggggaaag ccctggcttc gatctattct cctgatcaca cgaacaacag
     1501 cttctcctcc aacccttcaa ctcctgttgg ctcccctcct tcactctcag caggcacagc
     1561 tgtttggtct cgaaacggag gacaggcctc gtcatctccc aattacgaag gacccttgca
     1621 ctccttgcag agccgaattg aagaccgttt agaaagactg gacgacgcga ttcatgttct
     1681 ccggaaccac gcggtgggcc catccacagc tgtgcccggt ggccatgggg acatgcatgg
     1741 gatcatcgga ccctctcaca atggagcaat gggcagtctg ggctcaggat atggaactgg
     1801 ccttctctca gccaacagac attcactcat ggtcggggcc caccgtgaag atggcgtggc
     1861 actgagaggc agccattctc tcctgccaaa ccaggttccg gttccacagc ttccagtcca
     1921 gtctgcaact tcccctgact tgaacccacc ccaagaccct tacagaggga tgccaccagg
     1981 cctccaggga cagagtgtgt cttccggcag ctctgagatc aagtccgacg acgagggcga
     2041 tgagaaccta caggacacaa aatcttccga ggacaagaaa ctagacgacg acaagaagga
     2101 tatcaaatca attactaggt caagatctag caataacgat gatgaggacc tgaccccgga
     2161 gcagaaggcc gagcgtgaga aggagcggag gatggccaat aacgcccgtg agcgcctgag
     2221 ggtccgtgat atcaacgagg ctttcaagga gctgggccgc atggtacagc tccacctgaa
     2281 gagcgacaag ccccagacca agctcctgat tctccaccag gcagtggctg tcatcctcag
     2341 cctggagcag caagtgcgag aaaggaacct gaacccaaaa gctgcctgtc tgaaaagaag
     2401 ggaggaagag aaggtgtcct cagagcctcc cccgctctcc ttggctggcc cacaccctgg
     2461 gatgggagac gcagcgaatc acatgggtca gatgtgaaag ggtccaagtt gccaccttgc
     2521 ttcattaaaa caagagacca cttccttaac agctgtatta tcctaaaccc acataaacac
     2581 tgctccttaa ccccgttttt tttgtaatat aagacaagtc tgagtagtta tgaatcgcag
     2641 acgcaagagg tttcagcatt cccaattatc aaaaaacaga aaaacaaaca caaaaaaaaa
     2701 atgaatgaaa gaaagaaaga aagagaaaat gcaacttgag ggacgacttc tttaacatat
     2761 cactctgaat gtgcgaagcg gtatgtacag gctgagacgc agcccagaga ctgaatggca
     2821 atccttccac actgtggagc aatgcatttg tgcctaaact tcttttggaa aaaaaaatat
     2881 aattaatttg taagtctgaa aaaaaatatt taatttaaaa aaaattgtaa acttgcaata
     2941 atgaaaaagt gtacttctga agaaaaacga catgaacgtt tttgttggta ttcaagtcag
     3001 ctagtgtttc taattaccgg atattgaata gaggaagccc ggctaccctc ataacaaaac
     3061 cagcaaccgt cctgatggca accgaaatga tgacattagc cattccttag ggtaggaggg
     3121 acagatggat gttatagacc tatgacaaat atatatataa atatatatat aaatatatat
     3181 taaaaattta gtgactatgg taagcttttg ttcatttgtt tcagactttt ttctcctgta
     3241 aaaaaatagt actgattaac ttttttaaaa gaaagatttt actgtaaata tggatttttt
     3301 tttgtctgat ttttgtccct tcccccagtt tgttatcgtg acctgtagtg ccaactctgc
     3361 ttccggaggg gcagtgcagg acgaaatgct gaccctgatg ttgcttctca ttcataaata
     3421 gtagaaagtt gtttctccag tcttttggga acacaggact taaaagtcac atcatgtgta
     3481 gaaattacat gcagcattgc ccgggcaagg caaaaagagt ttgtctggct tgtggcactg
     3541 tgcttgttac cctctcctgg gattttcaga ggtacacggt tagaatgcta caatgttacc
     3601 actgtgcctt ccaatgttta tatcatcgga aacatgacat aatcaaagtg gctgtgattt
     3661 aacaaaaaaa aaaaaagatt caagtgttac ctacctgtgt agcggaagta gtgtgcagtg
     3721 agacgtttct gaatacatgg tcagattttt tttggaaaaa atacaaaaac aaaaaaaaaa
     3781 aacaaaaaaa tttaaaaaaa aaagtcaagt tcaaaaaccg tcaaatgaga aaatcgcaag
     3841 gagtgtgaca gctgattgat tttgttgctt ttcttgattt tttttttttt gtttccaaat
     3901 gggtttacta aaaagtacat gacttacctg cctcctcctt cgtctgaaaa caaaaaacaa
     3961 aaaaacaatg ccaacctatc ccacagcatt atagcaagcc ttataagccc taaagcatta
     4021 agttgcactt tggtgaggag gggtagcgca gtattctctc tggccagtat gagtgaagtt
     4081 tatacttaac atttgataga aacatagatc aaactgtggc acagtaactc atcagatagc
     4141 tagcgttgac tctgggcaca attgaaccaa ttcccatcct aaatctttcc aacaattgac
     4201 tttggtgtac agtgcagtga acacatagaa ctcctactta agtattcgtc agcatccttt
     4261 tgtctctaac tcggttctgt tttgacagcc acacaatctt ggcatgtatt aagtaaaaaa
     4321 aaaaaaaaaa tccctgttga agtagttttc ccacctatca gcactgagta attgccgtaa
     4381 ctcaatggaa atggtctaaa cgccccccat ctcttgtcct gtaccaccag ttacacagtg
     4441 acaaaacaca tctgtaaatt ttatgcaacc aatggcaaac ctatcattat tttgaaactg
     4501 tgtatgtaaa agttatattt ttacatgtag actcttgtta ttatgtgttt taatacattg
     4561 tatcagtttt ttgtttcctt ttttttttaa ctgtgtggtt ttaaaaagtc atttaaatga
     4621 aatagcgagc tacaagaatc tgaaatttat gttcatttct gaaaatgtaa gaacaaataa
     4681 gatagttatc acgtggtcac cttttacaaa cccatcgatg ttttgactag ctgtgtgtat
     4741 gtgtgtgtgt gcgcatgtgt gcgtgtgtgt gtatgtgtgt tgaaaactgt aaatatgttc
     4801 agtagcgata aaacgacaat gctttgattt gttgagaagt tcctaaaatg tggaggtgga
     4861 ttgaaaatgt aggggaatag cagaaatcag atttcatgaa gagctcttct cttcgggggc
     4921 tttcctgtgg aatggtcaaa cagaggtgct ccaagaaggg caaggaagac agtaacttcc
     4981 cctcctccct gaacgacgga aaccatgtgt acgtggtctc tcaccatgtt aaagattttc
     5041 tttccgtgat acattctgca ctctttttgt atagtctacc aaggcgggta tccctgggaa
     5101 caatattatg atataggaag cagtatactc tgatcacatt caggagaatt gtatagaaga
     5161 gaatatggtg tttactcttt agggaactgg aaattctccc tgcattgatg tacatcttca
     5221 gagcggccct tttgatacac gttatcataa aggtgctgac taaagcagaa ttaaagtttt
     5281 tcaaatctgt aaacaaagca aaaaattaaa ttacagtcat tcgattgttt gttttttttt
     5341 ttttccaatt ggtgctttta tattttgttc tcactcagac agaaaaggct gcaatttctt
     5401 gttcaccagc tttgatgtat tcattactcg gtaatgtaat acggctattg tcaaattcct
     5461 tttggaaata agcaaaaggc ttccccaagg cctgcagcag ctgctggcta ctttctgctt
     5521 ggcgcagaaa catgatctga ccctctctgt agtaatcgag ttgtatctcc agttttaaaa
     5581 agaaggaaaa agggaatgtg gccgttttaa tgtgtttttt tttttctttt cttgttgtta
     5641 ttttgtaatt ctcaaaccca ggtaagatat tggtattcct gcactggatt tttgaaagaa
     5701 acttagcaga agacaggatc gagatactat agaagcattt cccaagtgtt catactatac
     5761 tagacataaa tgataacggc gatgtatagg ttcaggatcg gtttaagaga ctcagacttt
     5821 gaaagcaact tggaacggtt gatccacctc cacattcgag taattaataa ttctgcagaa
     5881 ttagggatct gtccatctag gagttgttac ccatttgtct tctgtgtggc tgcgaggaac
     5941 actaacgctt ttacaactgt cagttcaccc agtggtacaa ctgattctga ctcagtcttc
     6001 cgattcctgt tttgtatttt gtttttccac ttttttccta tctcttgatt ttattgttgt
     6061 tgttattgct attgttatta ttattattcg tgatctttat ttcgatgagg ggttgggaag
     6121 tgggagggag tcgaactgag actaggggtt gagaggattt ttttggtttg gttttctttt
     6181 cttttttttt tgtttttttt tttttttgtt tgtttgtttc atctttgcgt ccaacaggca
     6241 gaatatggtc tgtgtccaaa acggaactta agtcaggaag gaaaccattc agcgtaaaca
     6301 agcacaacat gtagtctgtc ggctgtctgg aagcaaaaat aaattaataa ataaataata
     6361 aataagtaaa agacacacac ggaggtgaag atgaaatgtg atggattccg agacaatggg
     6421 gcaccaaggc ctgtaggcct cctcttgatt ttgctttggt tatgtttgtt ttccttagag
     6481 atgttttttt cctcacggga cttgaagtga ctcatctctg tgcagtaatg gtttcgccat
     6541 atgctcattt caagtattat agacatatgt aatggtgaaa tatatgaact gtggcctttt
     6601 tcattcttgt tatttgtgat gcaattaagt gaagagaaga aaaaaaaaag cagagattta
     6661 ccatgtatca gtgcctggct ttttgttata aagcttcgtc tgtctagtgc tctttttgct
     6721 ataaaaatag actgtagtac accctagtag gaaaaaaaaa ccctaaattt aaaaataaaa
     6781 aaatatattt ggcttatttt tcgcaggagc aatcctttta taccatggat attacaaaaa
     6841 aaaaaattgt cagattctga atatttcttc tttgtagatt tttggaatca ttataagtaa
     6901 aagtttgtta ctttatttta ctatttaaaa gatgttattt tgccatgtgt tactgagatg
     6961 aaactgtatg gtatagcttc ttctgttcgt tttttgtttc cggttttttg tttgttcgtt
     7021 tttggttttt tttttttttg tttgtttgtt ttgttttgtt tttttttctt agttgtaggt
     7081 cgcagtaagg acttttcctt ttgtttttgt tttttcgtta tgttttgttt tgtttttgcg
     7141 actgtacaca tagctgcagc attaaaaact tttaaaaaaa tctgttaaaa aaaaaagaaa
     7201 aaaaagggaa aacgtttaaa aaaaaaagat aaacagttac accttgtttt caacgtgtgg
     7261 ctgagtgcct cgattttttc atgtttttgg tgtatttctg atttgtagaa gtgtccaaac
     7321 aggttgtgtc ctggacttcc ttcaagaggc gaacaaccca gcttggtcta ggccatgacc
     7381 tgttcccatc tgtagttact cgatgaagtc atgtacatga ccgttctgta gcaataaatg
     7441 tgccattttt ataaa
//
LOCUS       NM_001437028            2231 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 15, mRNA.
ACCESSION   NM_001437028
VERSION     NM_001437028.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1661953.1,
                                           SRR26360176.2016860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-347              JAXUCZ010000016.1  6893598-6893876
            348-606             JAXUCZ010000016.1  6894275-6894533
            607-756             JAXUCZ010000016.1  6898222-6898371
            757-2231            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2231
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..347
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    262..264
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            348..606
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1929
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 15; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423957.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     364..438
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     439..1926
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    469..1380
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    469..1380
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(631..633,931..933,943..945,949..951,1030..1035,
                     1039..1044,1108..1110)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(631..633,931..933,943..945,949..951,1030..1035,
                     1039..1044,1108..1110)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(631..633,931..933,1030..1032)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(631..633,931..933,1030..1032)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    745..747
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    904..906
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(934..948,967..975,1033..1035,1039..1053,1060..1065,
                     1126..1131,1135..1143,1147..1152,1222..1227,1366..1380)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(934..948,967..975,1033..1035,1039..1053,1060..1065,
                     1126..1131,1135..1143,1147..1152,1222..1227,1366..1380)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1474..1923
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1474..1923
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1501..1503
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            607..756
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2231
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagaa aatcccatgt taccactatg agaaggattt tctttccaaa gcggtacgtc
      121 cttaagcaag tgattcggag tagcagacaa agcagaaaac agtgaaagcc gtgtgcggga
      181 ctctgacagg gagacttctt tatggctgcc ctgtgggtga cacagcagat gctagaattc
      241 caaaccgccc caaataaaaa ctgaagaata tcggctagga agctgccctg cgttcgggag
      301 cctcaggacc atcgcggctg tcctagaggg ctgacctgca atgctatatt tacggtctgc
      361 attatgtctg gagcccgcac tgcgcatgcg ctcgtcttcc tcctcggctg ttctgcgctt
      421 gcgttgggcg tctgctcagc ctccctggag cacggcgagg ctgagtacta cgtggctgcc
      481 gtgtacgaac accgatcggt cctgagccca aaccccctgg agctcagcag ccgccagcag
      541 gccctggagc tcatgaagca gaacctcgac gtctatgaac agcaagtgat ggctgcagcc
      601 cagaagggtg cgcacattat agtgttccca gaagacggta tccacggatt caacttcaca
      661 agaacatcca tttacccatt cttggacttg atgccatctc ccaggctggt cagttggaac
      721 ccgtgtctgg agccctttcg cttcaatgac acggaggtcc tccagcgcct gagttgcatg
      781 gccatcaagg gaaagatgtt cttggtggcc aatcttggga caaaacagcc ttgcctcggc
      841 agcgaccctg ggtgcccgca ggacgggaga taccagttta acacaaacgt cgcgttcagt
      901 gacaacggaa ccctcgtcgg ccgctaccgt aagcacaacc tgtactttga ggaagccttc
      961 gatagccctg ctgacgtgga cctcaccacc tttgatacgc cgttcgcggg caagttcggt
     1021 atgttcactt gctttgatat cctgttcttt gaccccgcgg tccggctcct cagagacttt
     1081 gaggtaaagc acattgcgta ccctacggcc tggatgaacc agctgccgct cttggcagcc
     1141 attgaaatcc agaaagcatt cgccaccgcc ttcggcgtca ccgttctggc agctaacatc
     1201 caccacccga ctctggggat gacgggcagt ggcatacaca cccctctgaa gtccttttgg
     1261 taccataaca tggacgaccc cgaaggtcac cttataattg cccgggtagc cacaaaccca
     1321 cagggcctcg ttgggacaga gaatacaact agtgaaatgg atccgtccca taggaagttc
     1381 ttaaaagtct tgtctgggga tccgtactgt gagaaggatg cccaggaagt gcgctgcgac
     1441 gaggctgcca agtggaacct gaacgcacca cctaccttcc actcggagat gatgtatgac
     1501 aatttcaccc tggtccccgt ctggggaaag gaaggccacc tccaggtgtg ctccaacagt
     1561 ctctgttgcc acttactttt cgagaggccc gccctgtcca aagagctata tgccctgggt
     1621 gtctttgacg gactccacac agtgcacggt acctactacg ttcaagcctg tgccctggtc
     1681 aagtgcgggg gcgctggctt tgaaacctgc gggcaggaga tctcggaggc cgagggcttg
     1741 tttgactttc atctgtgggg gaacttcagc accttgtatg tcttcccttt atttctcacc
     1801 tcggggatga ccctagacac ccctgaccag ctcgggtggg agagcgacca ctatttcttg
     1861 aggaagaggg gactgtcctc cggcctggtg acggcagctc tctatgggcg gttgtatgag
     1921 aggaattagg aaaactgtgg tcagcaggtt gggctctgca ggctggcctt gccttcccac
     1981 ggcccacaga tcccaaacac tgggaaaacc gccccgcccc tgtggcactg gatcccaccc
     2041 tggggaactg taagaagatg ggagaggcag ttcctccttc ctttctacat aatgactgag
     2101 atattttctg gtattttcta ttcacattat tctttttcaa gccacaccct cttaccacta
     2161 ctacacaatt ggttttaaag actaagccaa aaaaaaaaaa aaaaaataaa catcagctgc
     2221 cattctacaa a
//
LOCUS       NM_001437101            7174 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            25, mRNA.
ACCESSION   NM_001437101 XM_063277622
VERSION     NM_001437101.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7174)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7174)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7174)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7174)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7174)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7174)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7174)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7174)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7174)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7174)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277622.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.60182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000018.1  65218060-65218337
            279-351             JAXUCZ010000018.1  65221421-65221493
            352-413             JAXUCZ010000018.1  65334541-65334602
            414-510             JAXUCZ010000018.1  65337982-65338078
            511-572             JAXUCZ010000018.1  65391770-65391831
            573-702             JAXUCZ010000018.1  65437939-65438068
            703-752             JAXUCZ010000018.1  65438528-65438577
            753-858             JAXUCZ010000018.1  65507173-65507278
            859-989             JAXUCZ010000018.1  65511025-65511155
            990-1122            JAXUCZ010000018.1  65516916-65517048
            1123-1190           JAXUCZ010000018.1  65525175-65525242
            1191-1269           JAXUCZ010000018.1  65526319-65526397
            1270-1346           JAXUCZ010000018.1  65528841-65528917
            1347-1550           JAXUCZ010000018.1  65531547-65531750
            1551-1686           JAXUCZ010000018.1  65551334-65551469
            1687-1849           JAXUCZ010000018.1  65553405-65553567
            1850-2079           JAXUCZ010000018.1  65556812-65557041
            2080-2220           JAXUCZ010000018.1  65557878-65558018
            2221-7174           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7174
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..158
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             279..2216
                     /gene="Tcf4"
                     /note="isoform 22 is encoded by transcript variant 25;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 22"
                     /protein_id="NP_001424030.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLL
                     GGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVY
                     APSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLG
                     NSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANG
                     TDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA
                     VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDM
                     HGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQ
                     LPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKL
                     DDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELG
                     RMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPP
                     PLSLAGPHPGMGDAANHMGQM"
     misc_feature    609..>1094
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    609..>1094
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1884..2138
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1884..2138
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1908..1910,1920..1922,1926..1934,1938..1940,
                     1953..1955,2016..2021)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1908..1910,1920..1922,1926..1934,1938..1940,
                     1953..1955,2016..2021)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1947..1952,1959..1964,1968..1973,1980..1982,
                     1992..1994,2022..2024,2031..2033,2043..2045,2052..2054,
                     2061..2078)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1947..1952,1959..1964,1968..1973,1980..1982,
                     1992..1994,2022..2024,2031..2033,2043..2045,2052..2054,
                     2061..2078)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            279..351
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            352..413
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..510
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..572
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            573..702
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            703..752
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..858
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            859..989
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1122
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1190
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1269
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1346
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1550
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1686
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1849
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2079
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2220
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..7174
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaaagcaa aacttgcttt gcagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
       61 tgtgtgtgtg tgagagagag agagagagag agagagagag agagagagag agttacagag
      121 acagacagag agacagacag aagtgagagg ggatgtaaac tcgaatcaat ttcaaagtgc
      181 ctccggtgga tgaacccggc aaatcctcaa ctgttcaggc ttcagattgt aactggcgat
      241 ctgaggggga aaatgaggtg ctgggtgaat tttccttgat gttttcgcct cctgtaagca
      301 gtgggaaaaa tggaccaact tctttggcga gtggacattt tacgggctca aatgtagaag
      361 acagaagtag ctcagggtcc tgggggaatg gaggtcatcc aagcccgtcc aggaactatg
      421 gagatgggac tccctatgac cacatgacta gcagggatct tgggtcacat gacaatctct
      481 ctccaccttt tgtcaattcc agaatacaaa gtaaaacaga aaggggttca tactcatctt
      541 atgggagaga aaacgtacag ggttgccacc agcagagtct cctcggaggg gacatggata
      601 tgggcaaccc aggaaccctt tcgcccacca aacctggctc ccagtactac ccatattcca
      661 gcaataacgc ccgacggagg cctcttcaca gtagtaccat ggaggtgcag acaaagaaag
      721 tcagaaaagt tcctccaggc ttgccatctt cagtctacgc tccttcagcc agcactgccg
      781 actacaacag ggactcacca ggctattctt cctccaagcc agcagccagc actttctcca
      841 gctccttctt catgcaagat ggccatcaca gcagtgaccc ttggagctcc tccagtggaa
      901 tgaatcagcc cggctatgga gggatgctag gcaactctca tatcccacag tctagcagct
      961 actgtagcct gcatccacat gaacgtctga gctatccatc gcactcctcg gcagacatca
     1021 actccagtct tcctccgatg tccacgttcc atcgaagtgg cacaaaccat tacagcacct
     1081 cttcctgcac acctcctgcc aacggaacag acagtataat ggcaaacaga ggaactgggg
     1141 cagcaggcag ctcccagact ggagacgctc tggggaaagc cctggcttcg atctattctc
     1201 ctgatcacac gaacaacagc ttctcctcca acccttcaac tcctgttggc tcccctcctt
     1261 cactctcagc aggcacagct gtttggtctc gaaacggagg acaggcctcg tcatctccca
     1321 attacgaagg acccttgcac tccttgcaga gccgaattga agaccgttta gaaagactgg
     1381 acgacgcgat tcatgttctc cggaaccacg cggtgggccc atccacagct gtgcccggtg
     1441 gccatgggga catgcatggg atcatcggac cctctcacaa tggagcaatg ggcagtctgg
     1501 gctcaggata tggaactggc cttctctcag ccaacagaca ttcactcatg gtcggggccc
     1561 accgtgaaga tggcgtggca ctgagaggca gccattctct cctgccaaac caggttccgg
     1621 ttccacagct tccagtccag tctgcaactt cccctgactt gaacccaccc caagaccctt
     1681 acagagggat gccaccaggc ctccagggac agagtgtgtc ttccggcagc tctgagatca
     1741 agtccgacga cgagggcgat gagaacctac aggacacaaa atcttccgag gacaagaaac
     1801 tagacgacga caagaaggat atcaaatcaa ttactaggtc aagatctagc aataacgatg
     1861 atgaggacct gaccccggag cagaaggccg agcgtgagaa ggagcggagg atggccaata
     1921 acgcccgtga gcgcctgagg gtccgtgata tcaacgaggc tttcaaggag ctgggccgca
     1981 tggtacagct ccacctgaag agcgacaagc cccagaccaa gctcctgatt ctccaccagg
     2041 cagtggctgt catcctcagc ctggagcagc aagtgcgaga aaggaacctg aacccaaaag
     2101 ctgcctgtct gaaaagaagg gaggaagaga aggtgtcctc agagcctccc ccgctctcct
     2161 tggctggccc acaccctggg atgggagacg cagcgaatca catgggtcag atgtgaaagg
     2221 gtccaagttg ccaccttgct tcattaaaac aagagaccac ttccttaaca gctgtattat
     2281 cctaaaccca cataaacact gctccttaac cccgtttttt ttgtaatata agacaagtct
     2341 gagtagttat gaatcgcaga cgcaagaggt ttcagcattc ccaattatca aaaaacagaa
     2401 aaacaaacac aaaaaaaaaa tgaatgaaag aaagaaagaa agagaaaatg caacttgagg
     2461 gacgacttct ttaacatatc actctgaatg tgcgaagcgg tatgtacagg ctgagacgca
     2521 gcccagagac tgaatggcaa tccttccaca ctgtggagca atgcatttgt gcctaaactt
     2581 cttttggaaa aaaaaatata attaatttgt aagtctgaaa aaaaatattt aatttaaaaa
     2641 aaattgtaaa cttgcaataa tgaaaaagtg tacttctgaa gaaaaacgac atgaacgttt
     2701 ttgttggtat tcaagtcagc tagtgtttct aattaccgga tattgaatag aggaagcccg
     2761 gctaccctca taacaaaacc agcaaccgtc ctgatggcaa ccgaaatgat gacattagcc
     2821 attccttagg gtaggaggga cagatggatg ttatagacct atgacaaata tatatataaa
     2881 tatatatata aatatatatt aaaaatttag tgactatggt aagcttttgt tcatttgttt
     2941 cagacttttt tctcctgtaa aaaaatagta ctgattaact tttttaaaag aaagatttta
     3001 ctgtaaatat ggattttttt ttgtctgatt tttgtccctt cccccagttt gttatcgtga
     3061 cctgtagtgc caactctgct tccggagggg cagtgcagga cgaaatgctg accctgatgt
     3121 tgcttctcat tcataaatag tagaaagttg tttctccagt cttttgggaa cacaggactt
     3181 aaaagtcaca tcatgtgtag aaattacatg cagcattgcc cgggcaaggc aaaaagagtt
     3241 tgtctggctt gtggcactgt gcttgttacc ctctcctggg attttcagag gtacacggtt
     3301 agaatgctac aatgttacca ctgtgccttc caatgtttat atcatcggaa acatgacata
     3361 atcaaagtgg ctgtgattta acaaaaaaaa aaaaagattc aagtgttacc tacctgtgta
     3421 gcggaagtag tgtgcagtga gacgtttctg aatacatggt cagatttttt ttggaaaaaa
     3481 tacaaaaaca aaaaaaaaaa acaaaaaaat ttaaaaaaaa aagtcaagtt caaaaaccgt
     3541 caaatgagaa aatcgcaagg agtgtgacag ctgattgatt ttgttgcttt tcttgatttt
     3601 tttttttttg tttccaaatg ggtttactaa aaagtacatg acttacctgc ctcctccttc
     3661 gtctgaaaac aaaaaacaaa aaaacaatgc caacctatcc cacagcatta tagcaagcct
     3721 tataagccct aaagcattaa gttgcacttt ggtgaggagg ggtagcgcag tattctctct
     3781 ggccagtatg agtgaagttt atacttaaca tttgatagaa acatagatca aactgtggca
     3841 cagtaactca tcagatagct agcgttgact ctgggcacaa ttgaaccaat tcccatccta
     3901 aatctttcca acaattgact ttggtgtaca gtgcagtgaa cacatagaac tcctacttaa
     3961 gtattcgtca gcatcctttt gtctctaact cggttctgtt ttgacagcca cacaatcttg
     4021 gcatgtatta agtaaaaaaa aaaaaaaaat ccctgttgaa gtagttttcc cacctatcag
     4081 cactgagtaa ttgccgtaac tcaatggaaa tggtctaaac gccccccatc tcttgtcctg
     4141 taccaccagt tacacagtga caaaacacat ctgtaaattt tatgcaacca atggcaaacc
     4201 tatcattatt ttgaaactgt gtatgtaaaa gttatatttt tacatgtaga ctcttgttat
     4261 tatgtgtttt aatacattgt atcagttttt tgtttccttt tttttttaac tgtgtggttt
     4321 taaaaagtca tttaaatgaa atagcgagct acaagaatct gaaatttatg ttcatttctg
     4381 aaaatgtaag aacaaataag atagttatca cgtggtcacc ttttacaaac ccatcgatgt
     4441 tttgactagc tgtgtgtatg tgtgtgtgtg cgcatgtgtg cgtgtgtgtg tatgtgtgtt
     4501 gaaaactgta aatatgttca gtagcgataa aacgacaatg ctttgatttg ttgagaagtt
     4561 cctaaaatgt ggaggtggat tgaaaatgta ggggaatagc agaaatcaga tttcatgaag
     4621 agctcttctc ttcgggggct ttcctgtgga atggtcaaac agaggtgctc caagaagggc
     4681 aaggaagaca gtaacttccc ctcctccctg aacgacggaa accatgtgta cgtggtctct
     4741 caccatgtta aagattttct ttccgtgata cattctgcac tctttttgta tagtctacca
     4801 aggcgggtat ccctgggaac aatattatga tataggaagc agtatactct gatcacattc
     4861 aggagaattg tatagaagag aatatggtgt ttactcttta gggaactgga aattctccct
     4921 gcattgatgt acatcttcag agcggccctt ttgatacacg ttatcataaa ggtgctgact
     4981 aaagcagaat taaagttttt caaatctgta aacaaagcaa aaaattaaat tacagtcatt
     5041 cgattgtttg tttttttttt tttccaattg gtgcttttat attttgttct cactcagaca
     5101 gaaaaggctg caatttcttg ttcaccagct ttgatgtatt cattactcgg taatgtaata
     5161 cggctattgt caaattcctt ttggaaataa gcaaaaggct tccccaaggc ctgcagcagc
     5221 tgctggctac tttctgcttg gcgcagaaac atgatctgac cctctctgta gtaatcgagt
     5281 tgtatctcca gttttaaaaa gaaggaaaaa gggaatgtgg ccgttttaat gtgttttttt
     5341 ttttcttttc ttgttgttat tttgtaattc tcaaacccag gtaagatatt ggtattcctg
     5401 cactggattt ttgaaagaaa cttagcagaa gacaggatcg agatactata gaagcatttc
     5461 ccaagtgttc atactatact agacataaat gataacggcg atgtataggt tcaggatcgg
     5521 tttaagagac tcagactttg aaagcaactt ggaacggttg atccacctcc acattcgagt
     5581 aattaataat tctgcagaat tagggatctg tccatctagg agttgttacc catttgtctt
     5641 ctgtgtggct gcgaggaaca ctaacgcttt tacaactgtc agttcaccca gtggtacaac
     5701 tgattctgac tcagtcttcc gattcctgtt ttgtattttg tttttccact tttttcctat
     5761 ctcttgattt tattgttgtt gttattgcta ttgttattat tattattcgt gatctttatt
     5821 tcgatgaggg gttgggaagt gggagggagt cgaactgaga ctaggggttg agaggatttt
     5881 tttggtttgg ttttcttttc tttttttttt gttttttttt ttttttgttt gtttgtttca
     5941 tctttgcgtc caacaggcag aatatggtct gtgtccaaaa cggaacttaa gtcaggaagg
     6001 aaaccattca gcgtaaacaa gcacaacatg tagtctgtcg gctgtctgga agcaaaaata
     6061 aattaataaa taaataataa ataagtaaaa gacacacacg gaggtgaaga tgaaatgtga
     6121 tggattccga gacaatgggg caccaaggcc tgtaggcctc ctcttgattt tgctttggtt
     6181 atgtttgttt tccttagaga tgtttttttc ctcacgggac ttgaagtgac tcatctctgt
     6241 gcagtaatgg tttcgccata tgctcatttc aagtattata gacatatgta atggtgaaat
     6301 atatgaactg tggccttttt cattcttgtt atttgtgatg caattaagtg aagagaagaa
     6361 aaaaaaaagc agagatttac catgtatcag tgcctggctt tttgttataa agcttcgtct
     6421 gtctagtgct ctttttgcta taaaaataga ctgtagtaca ccctagtagg aaaaaaaaac
     6481 cctaaattta aaaataaaaa aatatatttg gcttattttt cgcaggagca atccttttat
     6541 accatggata ttacaaaaaa aaaaattgtc agattctgaa tatttcttct ttgtagattt
     6601 ttggaatcat tataagtaaa agtttgttac tttattttac tatttaaaag atgttatttt
     6661 gccatgtgtt actgagatga aactgtatgg tatagcttct tctgttcgtt ttttgtttcc
     6721 ggttttttgt ttgttcgttt ttggtttttt ttttttttgt ttgtttgttt tgttttgttt
     6781 ttttttctta gttgtaggtc gcagtaagga cttttccttt tgtttttgtt ttttcgttat
     6841 gttttgtttt gtttttgcga ctgtacacat agctgcagca ttaaaaactt ttaaaaaaat
     6901 ctgttaaaaa aaaaagaaaa aaaagggaaa acgtttaaaa aaaaaagata aacagttaca
     6961 ccttgttttc aacgtgtggc tgagtgcctc gattttttca tgtttttggt gtatttctga
     7021 tttgtagaag tgtccaaaca ggttgtgtcc tggacttcct tcaagaggcg aacaacccag
     7081 cttggtctag gccatgacct gttcccatct gtagttactc gatgaagtca tgtacatgac
     7141 cgttctgtag caataaatgt gccattttta taaa
//
LOCUS       NM_001437021            1952 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 7, mRNA.
ACCESSION   NM_001437021 XM_006252618
VERSION     NM_001437021.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252618.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.70558.1,
                                           SRR26643290.47341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-327              JAXUCZ010000016.1  6894275-6894533
            328-477             JAXUCZ010000016.1  6898222-6898371
            478-1952            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1952
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..327
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1650
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 7; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423950.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     85..159
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     160..1647
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    190..1101
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    190..1101
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(352..354,652..654,664..666,670..672,751..756,
                     760..765,829..831)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(352..354,652..654,664..666,670..672,751..756,
                     760..765,829..831)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(352..354,652..654,751..753)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(352..354,652..654,751..753)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    466..468
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    625..627
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(655..669,688..696,754..756,760..774,781..786,
                     847..852,856..864,868..873,943..948,1087..1101)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(655..669,688..696,754..756,760..774,781..786,
                     847..852,856..864,868..873,943..948,1087..1101)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1195..1644
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1195..1644
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1222..1224
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            328..477
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1952
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagat ttacggtctg cattatgtct ggagcccgca ctgcgcatgc gctcgtcttc
      121 ctcctcggct gttctgcgct tgcgttgggc gtctgctcag cctccctgga gcacggcgag
      181 gctgagtact acgtggctgc cgtgtacgaa caccgatcgg tcctgagccc aaaccccctg
      241 gagctcagca gccgccagca ggccctggag ctcatgaagc agaacctcga cgtctatgaa
      301 cagcaagtga tggctgcagc ccagaagggt gcgcacatta tagtgttccc agaagacggt
      361 atccacggat tcaacttcac aagaacatcc atttacccat tcttggactt gatgccatct
      421 cccaggctgg tcagttggaa cccgtgtctg gagccctttc gcttcaatga cacggaggtc
      481 ctccagcgcc tgagttgcat ggccatcaag ggaaagatgt tcttggtggc caatcttggg
      541 acaaaacagc cttgcctcgg cagcgaccct gggtgcccgc aggacgggag ataccagttt
      601 aacacaaacg tcgcgttcag tgacaacgga accctcgtcg gccgctaccg taagcacaac
      661 ctgtactttg aggaagcctt cgatagccct gctgacgtgg acctcaccac ctttgatacg
      721 ccgttcgcgg gcaagttcgg tatgttcact tgctttgata tcctgttctt tgaccccgcg
      781 gtccggctcc tcagagactt tgaggtaaag cacattgcgt accctacggc ctggatgaac
      841 cagctgccgc tcttggcagc cattgaaatc cagaaagcat tcgccaccgc cttcggcgtc
      901 accgttctgg cagctaacat ccaccacccg actctgggga tgacgggcag tggcatacac
      961 acccctctga agtccttttg gtaccataac atggacgacc ccgaaggtca ccttataatt
     1021 gcccgggtag ccacaaaccc acagggcctc gttgggacag agaatacaac tagtgaaatg
     1081 gatccgtccc ataggaagtt cttaaaagtc ttgtctgggg atccgtactg tgagaaggat
     1141 gcccaggaag tgcgctgcga cgaggctgcc aagtggaacc tgaacgcacc acctaccttc
     1201 cactcggaga tgatgtatga caatttcacc ctggtccccg tctggggaaa ggaaggccac
     1261 ctccaggtgt gctccaacag tctctgttgc cacttacttt tcgagaggcc cgccctgtcc
     1321 aaagagctat atgccctggg tgtctttgac ggactccaca cagtgcacgg tacctactac
     1381 gttcaagcct gtgccctggt caagtgcggg ggcgctggct ttgaaacctg cgggcaggag
     1441 atctcggagg ccgagggctt gtttgacttt catctgtggg ggaacttcag caccttgtat
     1501 gtcttccctt tatttctcac ctcggggatg accctagaca cccctgacca gctcgggtgg
     1561 gagagcgacc actatttctt gaggaagagg ggactgtcct ccggcctggt gacggcagct
     1621 ctctatgggc ggttgtatga gaggaattag gaaaactgtg gtcagcaggt tgggctctgc
     1681 aggctggcct tgccttccca cggcccacag atcccaaaca ctgggaaaac cgccccgccc
     1741 ctgtggcact ggatcccacc ctggggaact gtaagaagat gggagaggca gttcctcctt
     1801 cctttctaca taatgactga gatattttct ggtattttct attcacatta ttctttttca
     1861 agccacaccc tcttaccact actacacaat tggttttaaa gactaagcca aaaaaaaaaa
     1921 aaaaaaataa acatcagctg ccattctaca aa
//
LOCUS       NM_001437094            5027 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 15, mRNA.
ACCESSION   NM_001437094 XM_039110368
VERSION     NM_001437094.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039110368.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2371232.1,
                                           SRR26360172.2209461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-712             JAXUCZ010000005.1  148181206-148181372
            713-983             JAXUCZ010000005.1  148183570-148183840
            984-1077            JAXUCZ010000005.1  148195258-148195351
            1078-1179           JAXUCZ010000005.1  148197680-148197781
            1180-1331           JAXUCZ010000005.1  148200975-148201126
            1332-1470           JAXUCZ010000005.1  148203568-148203706
            1471-1614           JAXUCZ010000005.1  148205552-148205695
            1615-1911           JAXUCZ010000005.1  148206678-148206974
            1912-2148           JAXUCZ010000005.1  148208059-148208295
            2149-2416           JAXUCZ010000005.1  148218465-148218732
            2417-2546           JAXUCZ010000005.1  148219783-148219912
            2547-2675           JAXUCZ010000005.1  148221617-148221745
            2676-2813           JAXUCZ010000005.1  148225153-148225290
            2814-2939           JAXUCZ010000005.1  148228732-148228857
            2940-3061           JAXUCZ010000005.1  148229514-148229635
            3062-3254           JAXUCZ010000005.1  148231206-148231398
            3255-5027           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5027
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3386
                     /gene="Pum1"
                     /note="isoform 15 is encoded by transcript variant 15;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 15"
                     /protein_id="NP_001424023.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEGPRDADSDENDKGEKK
                     NKGAFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGP
                     NQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSA
                     AATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYI
                     ISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSA
                     TQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAG
                     MPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAAS
                     ANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFS
                     QGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRT
                     SSSLAPIGHSFYNSLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLT
                     NGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDF
                     RNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMV
                     DVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNE
                     MVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVI
                     QRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGN
                     VLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQ
                     KMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNG
                     II"
     misc_feature    2352..3317
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2352..3317
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2520..2525,2532..2534,2628..2633,2640..2642,
                     2739..2741,2748..2750,2844..2849,2856..2858,2943..2948,
                     2952..2957,2964..2966,3051..3056,3060..3065,3072..3074,
                     3180..3185,3189..3194,3201..3203,3291..3293,3300..3302)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2520..2525,2532..2534,2628..2633,2640..2642,
                     2739..2741,2748..2750,2844..2849,2856..2858,2943..2948,
                     2952..2957,2964..2966,3051..3056,3060..3065,3072..3074,
                     3180..3185,3189..3194,3201..3203,3291..3293,3300..3302)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..712
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1179
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1331
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1614
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1911
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2148
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2416
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2546
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2675
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2813
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2939
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3061
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3254
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..5027
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagggccc aagggatgca gacagtgatg aaaacgacaa aggtgaaaag aagaacaagg
      601 gtgcgtttga tggagataag ctaggagatt tgaaggagga gggagatgtg atggacaaga
      661 ccaatggttt gccagtgcag aatgggattg atgcagacgt caaagatttt agccgtaccc
      721 ctggtaattg ccagagctct gctaatgaag tggatcttct gggtccaaac cagaatggtt
      781 ctgagggctt agcccagctg accagcacca atggtgccaa gcctgtggag gatttctcca
      841 acatggagtc ccagagtgtc cccttggacc ccatggaaca tgtgggcatg gagcctctgc
      901 agtttgatta ttcaggcacg caggtacctg tggactcagc agcagcaaca gtgggacttt
      961 ttgactacaa ttctcaacaa cagctattcc aaagacccaa tgcgcttgct gttcagcagt
     1021 tgacagctgc ccagcagcag caatatgcac ttgcagcagc ccaccagcct cacatcggtt
     1081 tagctcccgc tgcgtttgtc cccaacccat acatcatcag cgctgctccc ccagggacgg
     1141 acccctacac agctggattg gctgcagcag cgacactcgg cccagctgtg gtccctcacc
     1201 aatattatgg agtcacgcca tggggtgtct atcctgctag tcttttccag caacaagctg
     1261 ctgcagctgc agcagcaaca aattcagcta ctcagcagag tgccccacag gcccagcagg
     1321 gacagcagca ggttcttcgt ggaggagcta gccagcgtcc tttgacccca aatcagaacc
     1381 agcagggaca acaaacagat ccccttgtag cagctgcagc agtgaactct gctcttgcct
     1441 ttggacaagg attggctgca ggtatgccag gttatccagt cttggcacct gctgcttact
     1501 atgaccaaac tggtgccctt gtggtgaatg caggggcaag aaatggcctc ggagctccag
     1561 ttcggcttgt tgctccagcc ccagtcatca ttagctcctc agctgcacaa gcagctgttg
     1621 cagcggctgc agcttcagca aatggagcag ccggtggtct tgcaggaact acaaatggac
     1681 catttcgacc tttaggcacc cagcagcccc agccccagcc ccagcagcag cccagtaaca
     1741 atctggcttc cagctctttc tatggcaaca actctctgag cagtaactcc cagagcagct
     1801 ccctcttctc tcagggctcc gcccagcctg ccaacacgtc cttgggattc ggaagcagca
     1861 gttcccttgg tgccacccta ggatcggccc ttggagggtt tggaacagca gttgcaaact
     1921 ccaacactgg cagtggctcc cgccgtgact ccctgactgg cagcagtgac ctttataaga
     1981 ggacatcgag cagcttggcc cccattggac acagttttta taacagcctt agcttttcct
     2041 cctctcctgg acccgtgggc atgcctctcc ctagtcaggg accaggacat tcacagacac
     2101 cacctccttc cctctcttca catggatcct cttcaagctt aaacctggga ggactcacga
     2161 acggcagtgg aagatacatc tctgctgctc ctggtgccga agccaagtac cgcagtgcga
     2221 gcagtgcctc cagccttttc agccccagca gcaccctttt ttcttcctct cgtttgagat
     2281 acggaatgtc tgatgttatg ccctctggca ggagcagact tctggaagac tttcgaaaca
     2341 accggtaccc taatttacaa ctgcgggaga ttgccgggca tataatggaa ttttcccaag
     2401 accagcatgg ttctagattc attcagctga aactagagcg agccacagca gctgagcgcc
     2461 agcttgtctt caacgaaatc ctgcaggctg cgtaccaact tatggtggat gtgtttggaa
     2521 attacgtcat tcagaagttc tttgaatttg gcagccatga acagaagctg gctttggctg
     2581 aacggattcg aggccacgtc ctatcattgg cactgcagat gtatggctgc cgagtcatcc
     2641 agaaagcttt ggaatttatt ccctcagacc agcagaacga gatggtgcgg gagctagatg
     2701 gccatgtcct gaagtgtgtg aaagaccaga atggcaacca tgtggttcag aagtgcattg
     2761 aatgtgtaca gccccagtct ttgcagttca tcatcgatgc attcaagggg caggtgtttg
     2821 ctttgtctac gcacccatat ggctgtaggg tgatccagag gatcctggaa cactgtctcc
     2881 ccgaccagac cctccctatc ctggaggagc ttcaccagca cacggagcag ctcgtgcagg
     2941 atcagtatgg aaattatgta atccaacatg tcctggagca tggtcgtcct gaggataaaa
     3001 gcaaaattgt agcagagatc cgaggcaatg tacttgtatt gagtcagcac aaattcgcaa
     3061 gcaatgttgt ggagaagtgt gtcactcacg cctcacgtac agagcgtgct gtgctcattg
     3121 atgaggtatg caccatgaat gacggtcccc acagtgcctt atacaccatg atgaaggatc
     3181 agtatgccaa ttatgtggtc cagaagatga tcgatgtggc tgagccgggg cagcggaaga
     3241 ttgtcatgca caagatccgg ccacacatcg cgactcttcg gaagtacacc tatggcaagc
     3301 acatcctggc caagcttgag aagtactaca tgaagaatgg tgtggacttg gggcccattt
     3361 gtggtccccc taatgggatc atctgagcag tgcacccatc cctgtcccgc tgacctcact
     3421 gaccctggca gatccaacca gcaaccagag atgcccagct cagagtcgaa agtgggcgat
     3481 ggttgctccg ggattgctcc ctcctccaaa aatggaatcg gatccacttg tggaaaggcc
     3541 tttgtaaatt tcattttatt acacataaca tgtactaatt atttttttta attgactaat
     3601 tgccctgctg tttactggtg tataggaact tgtacatagg taatcagtgt acatgagagg
     3661 ccacatgctt tgttcaatgt tgtatctata ttccacatgt ggacactttc agggtggttg
     3721 gtttaacaaa aaaagtttta aaaaaagaca aaaaaaggtt tttaactcat ttgccttgtg
     3781 gcaagttttg caaatagctc ttccccaccc cattttatta aaaaaagaaa cctgagaaat
     3841 ttgaatttta gttaaataat ctcaaactgg catttaacac tgtttataaa atatatatat
     3901 atatatacat atatacatat gaaatgggaa cgtttccgag ttgctaaagc atcagcctgt
     3961 gatacggagt ttatgacgct ctttggagat gacctcatgc tgagggaggt ggtagctgca
     4021 gatccaggag gagcgggaag cacagagaca ggccggaggc cagtgggcat ggccacttgc
     4081 tctatgggtt gccttctgtg aacactggga agcagaatct gattatctag catgagagaa
     4141 cccagctctg ctcctggtct ggcttctata gatacatagt gtatacttgt gtagactttg
     4201 catatatacg gatttgtagt attttcctgt tttgatgtct aatctgtatc tataatgtac
     4261 cctagtagtc ggacatactt ttgattgtac aattgtacat ttgtatacct gtaatgtaaa
     4321 tgtggagaag tttgaatcaa catgaacacg tttttggtaa gaagagaacc ggccagcccg
     4381 tgcactctgt atatcccacc ttttatggtt gtagcagata gtgttgtata ttgtaaattg
     4441 taatttcaaa cagaagtaaa tttttttctt ttgaaggaat aaatgttctt tatacagcct
     4501 agttaatgtt taaaaagaaa aaatagcttg gtttatttgt cagctagtca agacggtagt
     4561 gagagccttt ctaaatgtta cttcagatga ttcagttcac actagtgttc cttttttttt
     4621 ttttatccta agaaaaggta atgtttcgct tattttgtga cagtcaaaag gatgtgcaga
     4681 agtttcgcct gccccttccc tgctcaccac ctccccttgt aaagtgactc accctccgtt
     4741 ttgtacagat gagctgtatt ttgcattttg tctacttgta agtgaatgta acatactgtc
     4801 aatcctcgtt tgaatataga ctgtaacact acacggtgta catttccaga gccttgtgta
     4861 tatttccaat gaactttttg caagcacact tgtaaccata tgtgtataat taacaaacct
     4921 gtgtatgctt atgcctgggc aactattttt tgtaactctt gtgtagattg tctctaaaca
     4981 atgtgtgatc tttattttga aaaaaataca gaactttgga atctgaa
//
LOCUS       NM_001437076            5318 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 5, mRNA.
ACCESSION   NM_001437076 XM_063288030
VERSION     NM_001437076.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5318)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5318)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5318)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5318)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5318)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5318)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5318)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5318)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5318)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5318)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14440.1,
                                           SRR26643285.20653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1470           JAXUCZ010000005.1  148197677-148197781
            1471-1622           JAXUCZ010000005.1  148200975-148201126
            1623-1761           JAXUCZ010000005.1  148203568-148203706
            1762-1905           JAXUCZ010000005.1  148205552-148205695
            1906-2202           JAXUCZ010000005.1  148206678-148206974
            2203-2439           JAXUCZ010000005.1  148208059-148208295
            2440-2707           JAXUCZ010000005.1  148218465-148218732
            2708-2837           JAXUCZ010000005.1  148219783-148219912
            2838-2966           JAXUCZ010000005.1  148221617-148221745
            2967-3104           JAXUCZ010000005.1  148225153-148225290
            3105-3230           JAXUCZ010000005.1  148228732-148228857
            3231-3352           JAXUCZ010000005.1  148229514-148229635
            3353-3545           JAXUCZ010000005.1  148231206-148231398
            3546-5318           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5318
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3677
                     /gene="Pum1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 5"
                     /protein_id="NP_001424005.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAA
                     TLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGG
                     ASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGAL
                     VVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPL
                     GTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSL
                     GATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSS
                     SPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRS
                     ASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIME
                     FSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQ
                     KLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGN
                     HVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEEL
                     HQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVT
                     HASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIR
                     PHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2643..3608
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2643..3608
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2811..2816,2823..2825,2919..2924,2931..2933,
                     3030..3032,3039..3041,3135..3140,3147..3149,3234..3239,
                     3243..3248,3255..3257,3342..3347,3351..3356,3363..3365,
                     3471..3476,3480..3485,3492..3494,3582..3584,3591..3593)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2811..2816,2823..2825,2919..2924,2931..2933,
                     3030..3032,3039..3041,3135..3140,3147..3149,3234..3239,
                     3243..3248,3255..3257,3342..3347,3351..3356,3363..3365,
                     3471..3476,3480..3485,3492..3494,3582..3584,3591..3593)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1622
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1761
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1905
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2202
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2439
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2707
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2837
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2966
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3104
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3230
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3352
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..5318
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcgcaggt ttagctcccg
     1381 ctgcgtttgt ccccaaccca tacatcatca gcgctgctcc cccagggacg gacccctaca
     1441 cagctggatt ggctgcagca gcgacactcg gcccagctgt ggtccctcac caatattatg
     1501 gagtcacgcc atggggtgtc tatcctgcta gtcttttcca gcaacaagct gctgcagctg
     1561 cagcagcaac aaattcagct actcagcaga gtgccccaca ggcccagcag ggacagcagc
     1621 aggttcttcg tggaggagct agccagcgtc ctttgacccc aaatcagaac cagcagggac
     1681 aacaaacaga tccccttgta gcagctgcag cagtgaactc tgctcttgcc tttggacaag
     1741 gattggctgc aggtatgcca ggttatccag tcttggcacc tgctgcttac tatgaccaaa
     1801 ctggtgccct tgtggtgaat gcaggggcaa gaaatggcct cggagctcca gttcggcttg
     1861 ttgctccagc cccagtcatc attagctcct cagctgcaca agcagctgtt gcagcggctg
     1921 cagcttcagc aaatggagca gccggtggtc ttgcaggaac tacaaatgga ccatttcgac
     1981 ctttaggcac ccagcagccc cagccccagc cccagcagca gcccagtaac aatctggctt
     2041 ccagctcttt ctatggcaac aactctctga gcagtaactc ccagagcagc tccctcttct
     2101 ctcagggctc cgcccagcct gccaacacgt ccttgggatt cggaagcagc agttcccttg
     2161 gtgccaccct aggatcggcc cttggagggt ttggaacagc agttgcaaac tccaacactg
     2221 gcagtggctc ccgccgtgac tccctgactg gcagcagtga cctttataag aggacatcga
     2281 gcagcttggc ccccattgga cacagttttt ataacagcct tagcttttcc tcctctcctg
     2341 gacccgtggg catgcctctc cctagtcagg gaccaggaca ttcacagaca ccacctcctt
     2401 ccctctcttc acatggatcc tcttcaagct taaacctggg aggactcacg aacggcagtg
     2461 gaagatacat ctctgctgct cctggtgccg aagccaagta ccgcagtgcg agcagtgcct
     2521 ccagcctttt cagccccagc agcacccttt tttcttcctc tcgtttgaga tacggaatgt
     2581 ctgatgttat gccctctggc aggagcagac ttctggaaga ctttcgaaac aaccggtacc
     2641 ctaatttaca actgcgggag attgccgggc atataatgga attttcccaa gaccagcatg
     2701 gttctagatt cattcagctg aaactagagc gagccacagc agctgagcgc cagcttgtct
     2761 tcaacgaaat cctgcaggct gcgtaccaac ttatggtgga tgtgtttgga aattacgtca
     2821 ttcagaagtt ctttgaattt ggcagccatg aacagaagct ggctttggct gaacggattc
     2881 gaggccacgt cctatcattg gcactgcaga tgtatggctg ccgagtcatc cagaaagctt
     2941 tggaatttat tccctcagac cagcagaacg agatggtgcg ggagctagat ggccatgtcc
     3001 tgaagtgtgt gaaagaccag aatggcaacc atgtggttca gaagtgcatt gaatgtgtac
     3061 agccccagtc tttgcagttc atcatcgatg cattcaaggg gcaggtgttt gctttgtcta
     3121 cgcacccata tggctgtagg gtgatccaga ggatcctgga acactgtctc cccgaccaga
     3181 ccctccctat cctggaggag cttcaccagc acacggagca gctcgtgcag gatcagtatg
     3241 gaaattatgt aatccaacat gtcctggagc atggtcgtcc tgaggataaa agcaaaattg
     3301 tagcagagat ccgaggcaat gtacttgtat tgagtcagca caaattcgca agcaatgttg
     3361 tggagaagtg tgtcactcac gcctcacgta cagagcgtgc tgtgctcatt gatgaggtat
     3421 gcaccatgaa tgacggtccc cacagtgcct tatacaccat gatgaaggat cagtatgcca
     3481 attatgtggt ccagaagatg atcgatgtgg ctgagccggg gcagcggaag attgtcatgc
     3541 acaagatccg gccacacatc gcgactcttc ggaagtacac ctatggcaag cacatcctgg
     3601 ccaagcttga gaagtactac atgaagaatg gtgtggactt ggggcccatt tgtggtcccc
     3661 ctaatgggat catctgagca gtgcacccat ccctgtcccg ctgacctcac tgaccctggc
     3721 agatccaacc agcaaccaga gatgcccagc tcagagtcga aagtgggcga tggttgctcc
     3781 gggattgctc cctcctccaa aaatggaatc ggatccactt gtggaaaggc ctttgtaaat
     3841 ttcattttat tacacataac atgtactaat tatttttttt aattgactaa ttgccctgct
     3901 gtttactggt gtataggaac ttgtacatag gtaatcagtg tacatgagag gccacatgct
     3961 ttgttcaatg ttgtatctat attccacatg tggacacttt cagggtggtt ggtttaacaa
     4021 aaaaagtttt aaaaaaagac aaaaaaaggt ttttaactca tttgccttgt ggcaagtttt
     4081 gcaaatagct cttccccacc ccattttatt aaaaaaagaa acctgagaaa tttgaatttt
     4141 agttaaataa tctcaaactg gcatttaaca ctgtttataa aatatatata tatatataca
     4201 tatatacata tgaaatggga acgtttccga gttgctaaag catcagcctg tgatacggag
     4261 tttatgacgc tctttggaga tgacctcatg ctgagggagg tggtagctgc agatccagga
     4321 ggagcgggaa gcacagagac aggccggagg ccagtgggca tggccacttg ctctatgggt
     4381 tgccttctgt gaacactggg aagcagaatc tgattatcta gcatgagaga acccagctct
     4441 gctcctggtc tggcttctat agatacatag tgtatacttg tgtagacttt gcatatatac
     4501 ggatttgtag tattttcctg ttttgatgtc taatctgtat ctataatgta ccctagtagt
     4561 cggacatact tttgattgta caattgtaca tttgtatacc tgtaatgtaa atgtggagaa
     4621 gtttgaatca acatgaacac gtttttggta agaagagaac cggccagccc gtgcactctg
     4681 tatatcccac cttttatggt tgtagcagat agtgttgtat attgtaaatt gtaatttcaa
     4741 acagaagtaa atttttttct tttgaaggaa taaatgttct ttatacagcc tagttaatgt
     4801 ttaaaaagaa aaaatagctt ggtttatttg tcagctagtc aagacggtag tgagagcctt
     4861 tctaaatgtt acttcagatg attcagttca cactagtgtt cctttttttt tttttatcct
     4921 aagaaaaggt aatgtttcgc ttattttgtg acagtcaaaa ggatgtgcag aagtttcgcc
     4981 tgccccttcc ctgctcacca cctccccttg taaagtgact caccctccgt tttgtacaga
     5041 tgagctgtat tttgcatttt gtctacttgt aagtgaatgt aacatactgt caatcctcgt
     5101 ttgaatatag actgtaacac tacacggtgt acatttccag agccttgtgt atatttccaa
     5161 tgaacttttt gcaagcacac ttgtaaccat atgtgtataa ttaacaaacc tgtgtatgct
     5221 tatgcctggg caactatttt ttgtaactct tgtgtagatt gtctctaaac aatgtgtgat
     5281 ctttattttg aaaaaaatac agaactttgg aatctgaa
//
LOCUS       NM_023091               4508 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus gamma-aminobutyric acid type A receptor subunit
            epsilon (Gabre), mRNA.
ACCESSION   NM_023091
VERSION     NM_023091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4508)
  AUTHORS   Hengen,K.B., Nelson,N.R., Stang,K.M., Johnson,S.M., Smith,S.M.,
            Watters,J.J., Mitchell,G.S. and Behan,M.
  TITLE     Daily isoflurane exposure increases barbiturate insensitivity in
            medullary respiratory and cortical neurons via expression of
            epsilon-subunit containing GABA ARs
  JOURNAL   PLoS One 10 (3), e0119351 (2015)
   PUBMED   25748028
  REMARK    GeneRIF: Daily isoflurane exposure increases barbiturate
            insensitivity in medullary respiratory and cortical neurons via
            expression of epsilon-subunit containing GABA ARs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4508)
  AUTHORS   Hengen,K.B., Nelson,N.R., Stang,K.M., Johnson,S.M., Crader,S.M.,
            Watters,J.J., Mitchell,G.S. and Behan,M.
  TITLE     Increased GABA(A) receptor epsilon-subunit expression on ventral
            respiratory column neurons protects breathing during pregnancy
  JOURNAL   PLoS One 7 (1), e30608 (2012)
   PUBMED   22303446
  REMARK    GeneRIF: Increased epsilon subunit expression may be critical to
            preserve respiratory function (and life) despite increased
            neurosteroid levels during pregnancy.
REFERENCE   3  (bases 1 to 4508)
  AUTHORS   Belujon,P., Baufreton,J., Grandoso,L., Boue-Grabot,E., Batten,T.F.,
            Ugedo,L., Garret,M. and Taupignon,A.I.
  TITLE     Inhibitory transmission in locus coeruleus neurons expressing GABAA
            receptor epsilon subunit has a number of unique properties
  JOURNAL   J Neurophysiol 102 (4), 2312-2325 (2009)
   PUBMED   19625540
REFERENCE   4  (bases 1 to 4508)
  AUTHORS   Pape,J.R., Bertrand,S.S., Lafon,P., Odessa,M.F., Chaigniau,M.,
            Stiles,J.K. and Garret,M.
  TITLE     Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit
            mRNAs during rat CNS development and immunolocalization of the
            epsilon subunit in developing postnatal spinal cord
  JOURNAL   Neuroscience 160 (1), 85-96 (2009)
   PUBMED   19249336
  REMARK    GeneRIF: Our findings suggest that various combinations of GABA(A)
            alpha3-, theta- and epsilon-subunits may be assembled at a regional
            and developmental level in the brain.
REFERENCE   5  (bases 1 to 4508)
  AUTHORS   Sergeeva,O.A., Andreeva,N., Garret,M., Scherer,A. and Haas,H.L.
  TITLE     Pharmacological properties of GABAA receptors in rat hypothalamic
            neurons expressing the epsilon-subunit
  JOURNAL   J Neurosci 25 (1), 88-95 (2005)
   PUBMED   15634770
  REMARK    GeneRIF: We addressed the localization of the GABAA receptor
            epsilon subunit protein in two identified hypothalamic neuron
            groups, tuberomamillary and orexinergic, and the related functional
            properties.
REFERENCE   6  (bases 1 to 4508)
  AUTHORS   Moragues,N., Ciofi,P., Lafon,P., Tramu,G. and Garret,M.
  TITLE     GABAA receptor epsilon subunit expression in identified peptidergic
            neurons of the rat hypothalamus
  JOURNAL   Brain Res 967 (1-2), 285-289 (2003)
   PUBMED   12650990
  REMARK    GeneRIF: Expression of GABA-A receptors containing the epsilon
            subunit in neurons of the rat hypothalamus suggests that these
            receptors are likely to be involved in the GABAergic control of
            these neurons.
REFERENCE   7  (bases 1 to 4508)
  AUTHORS   Kasparov,S., Davies,K.A., Patel,U.A., Boscan,P., Garret,M. and
            Paton,J.F.
  TITLE     GABA(A) receptor epsilon-subunit may confer benzodiazepine
            insensitivity to the caudal aspect of the nucleus tractus solitarii
            of the rat
  JOURNAL   J Physiol 536 (Pt 3), 785-796 (2001)
   PUBMED   11691872
REFERENCE   8  (bases 1 to 4508)
  AUTHORS   Moragues,N., Ciofi,P., Lafon,P., Odessa,M.F., Tramu,G. and
            Garret,M.
  TITLE     cDNA cloning and expression of a gamma-aminobutyric acid A receptor
            epsilon-subunit in rat brain
  JOURNAL   Eur J Neurosci 12 (12), 4318-4330 (2000)
   PUBMED   11122342
REFERENCE   9  (bases 1 to 4508)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
REFERENCE   10 (bases 1 to 4508)
  AUTHORS   Davies,P.A., Hanna,M.C., Hales,T.G. and Kirkness,E.F.
  TITLE     Insensitivity to anaesthetic agents conferred by a class of GABA(A)
            receptor subunit
  JOURNAL   Nature 385 (6619), 820-823 (1997)
   PUBMED   9039914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 26, 2025 this sequence version replaced NM_023091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000021.1  155120646-155120751 c
            107-1776            JAXUCZ010000021.1  155115527-155117196 c
            1777-1844           JAXUCZ010000021.1  155115068-155115135 c
            1845-2065           JAXUCZ010000021.1  155110405-155110625 c
            2066-2148           JAXUCZ010000021.1  155109626-155109708 c
            2149-2286           JAXUCZ010000021.1  155108327-155108464 c
            2287-2439           JAXUCZ010000021.1  155104510-155104662 c
            2440-2639           JAXUCZ010000021.1  155104194-155104393 c
            2640-4508           JAXUCZ010000021.1  155102078-155103946 c
FEATURES             Location/Qualifiers
     source          1..4508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..4508
                     /gene="Gabre"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     epsilon"
                     /db_xref="GeneID:65191"
                     /db_xref="RGD:68320"
     exon            1..106
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3020
                     /gene="Gabre"
                     /note="gamma-aminobutyric acid receptor subunit epsilon;
                     GABA(A) receptor subunit epsilon; gamma-aminobutyric acid
                     (GABA-A) receptor, subunit epsilon; gamma-aminobutyric
                     acid A receptor, epsilon; gamma-aminobutyric acid type A
                     receptor epsilon subunit; gamma-aminobutyric acid (GABA) A
                     receptor, epsilon; GABAAR subunit epsilon"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit epsilon
                     precursor"
                     /protein_id="NP_075579.1"
                     /db_xref="GeneID:65191"
                     /db_xref="RGD:68320"
                     /translation="MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQP
                     VPQPLIPPESPAGDDVVFDSQPQPQSESPGHDDVFSSQPQPLPQPQPLPEPQPLPEPE
                     PQPQPQPQPQPQPQPLAGRQPLPQPLPWPLPQPQPEPEPQPEPQPEPQPEPQPEPQPE
                     PQPEPQPEPQPQPQPLAGRQPLPWPLPLPLPEPQPDPQPDPQPEPQPEPQPEPQPQPQ
                     TPGQVQAGRQPRPKPQPDPHPHPQPEPQPEPRLHPFHRLRLRPHPYPEPHPGPQPEPE
                     PEPEPEPQPEPQPEPQPEPQPEPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE
                     PEPEPEPEPQPEPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPEPEPQPEPQPEPEPE
                     PEPEPEPEPEPEPEPQPEPQPEPEPQPEPQPDPEPQPEPGPEPGPEPEPEPQLEPQPE
                     PEPEPQPEPESELDLEPEPEPQPLPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE
                     PEPEPELELEPQSQLEPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNY
                     DHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETL
                     ILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLH
                     MLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEI
                     ISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASVGV
                     SSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQ
                     ASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSP
                     RSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNSWQRGRICIHVYRLDNYSRVLFP
                     ITFFFFNVVYWVICLNL"
     sig_peptide     51..101
                     /gene="Gabre"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ES14.1)"
     misc_feature    <210..422
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <210..422
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <408..581
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <408..581
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <636..797
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <636..797
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <837..995
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <837..995
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <918..1121
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <918..1121
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1062..1265
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1062..1265
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1176..1379
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1176..1379
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1446..1607
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    <1446..1607
                     /gene="Gabre"
                     /note="Procyclic acidic repetitive protein (PARP); Region:
                     Trypan_PARP; pfam05887"
                     /db_xref="CDD:368653"
     misc_feature    1719..2999
                     /gene="Gabre"
                     /note="Cation transporter family protein; Region: LIC;
                     cl42365"
                     /db_xref="CDD:455710"
     misc_feature    1719..2999
                     /gene="Gabre"
                     /note="Cation transporter family protein; Region: LIC;
                     cl42365"
                     /db_xref="CDD:455710"
     misc_feature    1785..2330
                     /gene="Gabre"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit epsilon (GABRE); Region:
                     LGIC_ECD_GABAAR_E; cd19002"
                     /db_xref="CDD:349803"
     misc_feature    1785..2330
                     /gene="Gabre"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit epsilon (GABRE); Region:
                     LGIC_ECD_GABAAR_E; cd19002"
                     /db_xref="CDD:349803"
     misc_feature    order(1806..1808,1863..1865)
                     /gene="Gabre"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:349803"
     misc_feature    order(1806..1808,1863..1865)
                     /gene="Gabre"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:349803"
     misc_feature    order(1815..1817,1821..1826,1839..1844,1863..1865,
                     1869..1874,1923..1925,1929..1934,1959..1976,1983..1985,
                     1989..1991,1995..2000,2016..2024,2028..2030,2058..2066,
                     2148..2150,2328..2330)
                     /gene="Gabre"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349803"
     misc_feature    order(1815..1817,1821..1826,1839..1844,1863..1865,
                     1869..1874,1923..1925,1929..1934,1959..1976,1983..1985,
                     1989..1991,1995..2000,2016..2024,2028..2030,2058..2066,
                     2148..2150,2328..2330)
                     /gene="Gabre"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349803"
     misc_feature    2085..2129
                     /gene="Gabre"
                     /note="Cys-loop [structural motif]; Region: Cys-loop"
                     /db_xref="CDD:349803"
     misc_feature    2085..2129
                     /gene="Gabre"
                     /note="Cys-loop [structural motif]; Region: Cys-loop"
                     /db_xref="CDD:349803"
     exon            107..1776
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1844
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2065
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2148
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2286
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2439
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2639
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..4508
                     /gene="Gabre"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgcgc tgcgacctcc acacaggtgg tcgtgccagg caccgctgag atgttgccta
       61 aagttctcct gatgctcctc aacatgttcc tggccctcca gtggagggtt ggacctcaca
      121 ttaaactgga gaataaaccc cctgcccaag ataaggtagt ctttggccct cagcctcagc
      181 ctgtgccaca acctctgatt ccgcctgaat ctcctgctgg agatgatgta gtcttcgact
      241 ctcagcccca gccccagtcg gaatcccctg gccatgatga tgtctttagc tcccagcccc
      301 agcctctgcc ccagccccag cctctgccgg agccccagcc tctgccggag cctgagccac
      361 agccgcagcc acagccacag ccgcagccgc agccacagcc cctggctggg cgccagcctc
      421 tgccccagcc cctgccttgg cccctgcctc agcctcagcc cgaaccggag ccccagccgg
      481 agccccagcc ggagccccag cctgagcccc agccggagcc ccagcctgag ccccaaccag
      541 aaccccagcc agaaccccag cctcaacctc agcctctggc tgggcgccag cctttgcctt
      601 ggcccctgcc actgcccctg cccgagcccc aacctgatcc ccagcctgat ccccaaccgg
      661 agcctcagcc agaaccccaa cctgagcccc agcctcagcc ccagacccca ggccaggtcc
      721 aggctgggcg ccaaccccgc cccaaacctc agcctgatcc ccatccccat ccgcagcctg
      781 aacctcagcc tgagccacgt ctccatccct ttcaccgtct ccgtctccgt ccccatccct
      841 atcctgagcc ccatccagga ccccagccgg agcctgagcc tgagcctgag ccggagcccc
      901 agccggagcc ccagccggag ccccagccgg agccccaacc ggagcctgag ccccagccgg
      961 agccggagcc ggagcctgag cctgagcctg agcctgagcc tgagcccgag cccgagcccg
     1021 agcccgagcc tgagcctgag cctgagcctg agcctgagcc tgagcctgag cctgagcccc
     1081 agccggagcc ggagccggag ccggagccgg agcccgaacc tgagcccgag cccgagcccg
     1141 agcccgagcc tcagccagag ccccagccag aacctgagcc tgagcccgag ccccagcccg
     1201 agccccagcc cgagcccgag cccgagcccg agcccgagcc cgagcccgag cccgaacctg
     1261 aacctgagcc tcagccggag ccccagcctg agcctgagcc ccagcctgag ccccagccag
     1321 atcctgagcc tcagcctgag cccggacctg aacctggacc tgaacctgaa cctgagcctc
     1381 agctggagcc ccagccagag cctgagcctg agccacagcc ggagcctgag tcggagctgg
     1441 acctggagcc ggaaccagag ccccagcccc tgccggagcc ccagcctgag cctgagcctg
     1501 agcctgagcc ggagccggag ccggagccgg agccggagcc ggagccggag ccggagccgg
     1561 agccggagcc tgagccagaa ccggagccag agctggaact ggagccccag tcccagctgg
     1621 agcctcagcc tagtggaaag aagcttccag caagagaaac agaactcact gctgatcata
     1681 caactgaacg cccacgtgga aaactgacaa gagcttctca aatccttaac accatcctga
     1741 gcaactacga ccataaactg cgccctagca ttggagagaa gcctaccgtg gtcactgtta
     1801 aagtctttgt caacagcctc ggacctattt ccatcctaga catggaatat tccattgaca
     1861 tcatcttcta ccagacctgg tatgatgagc gtcttcgtta caatgacacc tttgagacac
     1921 ttattctaca tggcaacgtg gtgagccagt tgtggatccc ggatactttt tttaggaatt
     1981 ctaagaggac ccaagagtat gatatcacca tacccaacca gatggctctc atccataagg
     2041 atggaaaagt gttgtacaca gttaggatga ccattgatgc aagatgctca ctccacatgc
     2101 tcaattttcc aatggattct cactcttgcc ctctgtcttt ctctagcttt tcctatgatg
     2161 agcatgagat gatatacaag tgggagaatt tcaaactcaa aatcgatgcg aagaacactt
     2221 ggaagctatt ggagtttgat tttacaggag tgaacaacaa aactgaaatc atctccaccc
     2281 cagttggtga cttcatggtc atgacattct tcttcaatgt aagcaggagg tttggcttca
     2341 ttgtctttca aaactatatc ccttcatctg ttaccacaat gctttcctgg gtgtccttct
     2401 ggatcaagat agaagctgct gctgccaggg cctctgtagg ggtcagttct gtgctcacca
     2461 tggccacact gggtaccttt tctcgtaaga atttccctcg tgtctcctat ctcacagctt
     2521 tggacttcta tattgcaatt tgtttcgtct tgtgcttctg tactctacta gagttcactg
     2581 tgctcaactt cctgacctac aataatattg aacgacaggc ttctccaaag ttctaccaat
     2641 ttccaaccaa tagccgtgct aatgcacgta ctcgtgctcg tgcccgcact cgtgctcgtg
     2701 ctcgtgcccg tgctcgtcag cagcaggaag tgtttgtgtg tgagattgtt acctatgagg
     2761 aaaatgctga agagggttac cagtggtctc caagatcaag aagacctcag tgtccctgga
     2821 ggcgatgtgg ccgaagctat gtgtgcttca gggttctcag gaagtatttc tgcatggttc
     2881 ctggttgtga gggcaacagc tggcagcggg gccgcatctg catccacgtt tatcgcctgg
     2941 ataactactc gcgggtgctt ttccccatta cattcttctt ctttaatgtg gtctactggg
     3001 tgatttgcct taacctgtag gctccagctg gtagctcatg gggcaatcac ctcagttccc
     3061 caggaggtcc taagcccctt tgtcaaggga gttgggagac aatagcaaca gcagcaagcc
     3121 tgaggagagt ttgtctttgc tgctcctcct tttgttggcc ccttcactca atcttttaaa
     3181 cagcacttct caagtaacag cccacctctc tattcttcaa agagtatcca tgatgttcag
     3241 tgtgcccaca attgagcaga taagctatct cttggttgtg tttgcagtta ctgtttttcc
     3301 ccaggaggtc atggtaccat ttgtggtgct aaggggccca gctcaagctc agccctagaa
     3361 tgcacagagc aacaacagta tagcagaagg aaggtcctca tccttaagtc tttaagtcag
     3421 gctatttgat tttttctccc tgctctctct tcctctacac acacacacac acacacacac
     3481 acacacacac actcacacac acacacacac acgcacgcac gcacgcacgc acaccactat
     3541 ctgtaggagg agaggagcca gcaagtgggc ctgtttggga aagtaaccgt ctctgctgcc
     3601 atgtcatctc cttctccccc cccccccccc gcctccatct gcactcccaa ttcagttccc
     3661 ttcatctaat gggtatctat tcttgtgtgc aatgtttgta atttcccctg ctttgtatgc
     3721 ctccttcttc ctcttccttg atccctgtga ttctttctgt aacttcccca gtgactttcc
     3781 cagccctgat ccaggtgcta ggctttgtgt ctcccaggga ccaagaaacc aagagcactc
     3841 tgttgagcag ctgccattgc ctatcactga ttggtgctca cctcaggcac agtctaatgg
     3901 tttgattgct tccttggtcc ctggacccat aagccagtcc actgccatcc ctggggcact
     3961 cacacaattg caatcaattg aactccctta aatttgtata acattttccc tttgacaaag
     4021 tacttttgac aaaacatttc tatttggaaa cttgttatag ccccgtgaca tctttgggca
     4081 cagattgtca tgatacaaat ggcaaccttg agacacagat ttctatggga ctctggatct
     4141 ttctggaagc caatatggag ccccctgtca cctgttaaag ggtatggcag ggttaggcag
     4201 ctctggtcaa gcatgactca attttatttc tcttgctggc accccagtag caaggactaa
     4261 agcgacaggt ccctctcagc actggcttgc tctataacta ggcctgaggt gctcagactg
     4321 ctccacaggt ttaactcttt gactctaata acccactgag atgaatttgt atatgcccca
     4381 atgcttgtat atgctgaata gaatcagtgt ctgtatttta tgggggtggg tgggattggg
     4441 aaatccatct gcttctagtc atcaccatct gtaaagggga tatatatgaa taaaagtatc
     4501 agcaaaca
//
LOCUS       NM_001437090            5033 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 13, mRNA.
ACCESSION   NM_001437090 XM_006239038
VERSION     NM_001437090.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5033)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5033)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5033)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5033)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5033)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5033)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5033)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5033)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5033)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5033)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006239038.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2044449.1,
                                           SRR26360176.787075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-712             JAXUCZ010000005.1  148181206-148181372
            713-983             JAXUCZ010000005.1  148183570-148183840
            984-1077            JAXUCZ010000005.1  148195258-148195351
            1078-1179           JAXUCZ010000005.1  148197680-148197781
            1180-1331           JAXUCZ010000005.1  148200975-148201126
            1332-1470           JAXUCZ010000005.1  148203568-148203706
            1471-1614           JAXUCZ010000005.1  148205552-148205695
            1615-1911           JAXUCZ010000005.1  148206678-148206974
            1912-2148           JAXUCZ010000005.1  148208059-148208295
            2149-2416           JAXUCZ010000005.1  148218465-148218732
            2417-2546           JAXUCZ010000005.1  148219783-148219912
            2547-2681           JAXUCZ010000005.1  148221617-148221751
            2682-2819           JAXUCZ010000005.1  148225153-148225290
            2820-2945           JAXUCZ010000005.1  148228732-148228857
            2946-3067           JAXUCZ010000005.1  148229514-148229635
            3068-3260           JAXUCZ010000005.1  148231206-148231398
            3261-5033           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5033
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3392
                     /gene="Pum1"
                     /note="isoform 13 is encoded by transcript variant 13;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 13"
                     /protein_id="NP_001424019.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEGPRDADSDENDKGEKK
                     NKGAFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGP
                     NQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSA
                     AATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYI
                     ISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSA
                     TQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAG
                     MPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAAS
                     ANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFS
                     QGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRT
                     SSSLAPIGHSFYNSLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLT
                     NGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDF
                     RNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMV
                     DVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVI
                     NEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCR
                     VIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIR
                     GNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYV
                     VQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPP
                     NGII"
     misc_feature    2352..3323
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2352..3323
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2520..2525,2532..2534,2628..2633,2640..2642,
                     2745..2747,2754..2756,2850..2855,2862..2864,2949..2954,
                     2958..2963,2970..2972,3057..3062,3066..3071,3078..3080,
                     3186..3191,3195..3200,3207..3209,3297..3299,3306..3308)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2520..2525,2532..2534,2628..2633,2640..2642,
                     2745..2747,2754..2756,2850..2855,2862..2864,2949..2954,
                     2958..2963,2970..2972,3057..3062,3066..3071,3078..3080,
                     3186..3191,3195..3200,3207..3209,3297..3299,3306..3308)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..712
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1179
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1331
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1614
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1911
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2148
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2416
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2546
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2681
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2819
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2945
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3067
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3260
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..5033
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagggccc aagggatgca gacagtgatg aaaacgacaa aggtgaaaag aagaacaagg
      601 gtgcgtttga tggagataag ctaggagatt tgaaggagga gggagatgtg atggacaaga
      661 ccaatggttt gccagtgcag aatgggattg atgcagacgt caaagatttt agccgtaccc
      721 ctggtaattg ccagagctct gctaatgaag tggatcttct gggtccaaac cagaatggtt
      781 ctgagggctt agcccagctg accagcacca atggtgccaa gcctgtggag gatttctcca
      841 acatggagtc ccagagtgtc cccttggacc ccatggaaca tgtgggcatg gagcctctgc
      901 agtttgatta ttcaggcacg caggtacctg tggactcagc agcagcaaca gtgggacttt
      961 ttgactacaa ttctcaacaa cagctattcc aaagacccaa tgcgcttgct gttcagcagt
     1021 tgacagctgc ccagcagcag caatatgcac ttgcagcagc ccaccagcct cacatcggtt
     1081 tagctcccgc tgcgtttgtc cccaacccat acatcatcag cgctgctccc ccagggacgg
     1141 acccctacac agctggattg gctgcagcag cgacactcgg cccagctgtg gtccctcacc
     1201 aatattatgg agtcacgcca tggggtgtct atcctgctag tcttttccag caacaagctg
     1261 ctgcagctgc agcagcaaca aattcagcta ctcagcagag tgccccacag gcccagcagg
     1321 gacagcagca ggttcttcgt ggaggagcta gccagcgtcc tttgacccca aatcagaacc
     1381 agcagggaca acaaacagat ccccttgtag cagctgcagc agtgaactct gctcttgcct
     1441 ttggacaagg attggctgca ggtatgccag gttatccagt cttggcacct gctgcttact
     1501 atgaccaaac tggtgccctt gtggtgaatg caggggcaag aaatggcctc ggagctccag
     1561 ttcggcttgt tgctccagcc ccagtcatca ttagctcctc agctgcacaa gcagctgttg
     1621 cagcggctgc agcttcagca aatggagcag ccggtggtct tgcaggaact acaaatggac
     1681 catttcgacc tttaggcacc cagcagcccc agccccagcc ccagcagcag cccagtaaca
     1741 atctggcttc cagctctttc tatggcaaca actctctgag cagtaactcc cagagcagct
     1801 ccctcttctc tcagggctcc gcccagcctg ccaacacgtc cttgggattc ggaagcagca
     1861 gttcccttgg tgccacccta ggatcggccc ttggagggtt tggaacagca gttgcaaact
     1921 ccaacactgg cagtggctcc cgccgtgact ccctgactgg cagcagtgac ctttataaga
     1981 ggacatcgag cagcttggcc cccattggac acagttttta taacagcctt agcttttcct
     2041 cctctcctgg acccgtgggc atgcctctcc ctagtcaggg accaggacat tcacagacac
     2101 cacctccttc cctctcttca catggatcct cttcaagctt aaacctggga ggactcacga
     2161 acggcagtgg aagatacatc tctgctgctc ctggtgccga agccaagtac cgcagtgcga
     2221 gcagtgcctc cagccttttc agccccagca gcaccctttt ttcttcctct cgtttgagat
     2281 acggaatgtc tgatgttatg ccctctggca ggagcagact tctggaagac tttcgaaaca
     2341 accggtaccc taatttacaa ctgcgggaga ttgccgggca tataatggaa ttttcccaag
     2401 accagcatgg ttctagattc attcagctga aactagagcg agccacagca gctgagcgcc
     2461 agcttgtctt caacgaaatc ctgcaggctg cgtaccaact tatggtggat gtgtttggaa
     2521 attacgtcat tcagaagttc tttgaatttg gcagccatga acagaagctg gctttggctg
     2581 aacggattcg aggccacgtc ctatcattgg cactgcagat gtatggctgc cgagtcatcc
     2641 agaaagcttt ggaatttatt ccctcagacc agcaggtaat taacgagatg gtgcgggagc
     2701 tagatggcca tgtcctgaag tgtgtgaaag accagaatgg caaccatgtg gttcagaagt
     2761 gcattgaatg tgtacagccc cagtctttgc agttcatcat cgatgcattc aaggggcagg
     2821 tgtttgcttt gtctacgcac ccatatggct gtagggtgat ccagaggatc ctggaacact
     2881 gtctccccga ccagaccctc cctatcctgg aggagcttca ccagcacacg gagcagctcg
     2941 tgcaggatca gtatggaaat tatgtaatcc aacatgtcct ggagcatggt cgtcctgagg
     3001 ataaaagcaa aattgtagca gagatccgag gcaatgtact tgtattgagt cagcacaaat
     3061 tcgcaagcaa tgttgtggag aagtgtgtca ctcacgcctc acgtacagag cgtgctgtgc
     3121 tcattgatga ggtatgcacc atgaatgacg gtccccacag tgccttatac accatgatga
     3181 aggatcagta tgccaattat gtggtccaga agatgatcga tgtggctgag ccggggcagc
     3241 ggaagattgt catgcacaag atccggccac acatcgcgac tcttcggaag tacacctatg
     3301 gcaagcacat cctggccaag cttgagaagt actacatgaa gaatggtgtg gacttggggc
     3361 ccatttgtgg tccccctaat gggatcatct gagcagtgca cccatccctg tcccgctgac
     3421 ctcactgacc ctggcagatc caaccagcaa ccagagatgc ccagctcaga gtcgaaagtg
     3481 ggcgatggtt gctccgggat tgctccctcc tccaaaaatg gaatcggatc cacttgtgga
     3541 aaggcctttg taaatttcat tttattacac ataacatgta ctaattattt tttttaattg
     3601 actaattgcc ctgctgttta ctggtgtata ggaacttgta cataggtaat cagtgtacat
     3661 gagaggccac atgctttgtt caatgttgta tctatattcc acatgtggac actttcaggg
     3721 tggttggttt aacaaaaaaa gttttaaaaa aagacaaaaa aaggttttta actcatttgc
     3781 cttgtggcaa gttttgcaaa tagctcttcc ccaccccatt ttattaaaaa aagaaacctg
     3841 agaaatttga attttagtta aataatctca aactggcatt taacactgtt tataaaatat
     3901 atatatatat atacatatat acatatgaaa tgggaacgtt tccgagttgc taaagcatca
     3961 gcctgtgata cggagtttat gacgctcttt ggagatgacc tcatgctgag ggaggtggta
     4021 gctgcagatc caggaggagc gggaagcaca gagacaggcc ggaggccagt gggcatggcc
     4081 acttgctcta tgggttgcct tctgtgaaca ctgggaagca gaatctgatt atctagcatg
     4141 agagaaccca gctctgctcc tggtctggct tctatagata catagtgtat acttgtgtag
     4201 actttgcata tatacggatt tgtagtattt tcctgttttg atgtctaatc tgtatctata
     4261 atgtacccta gtagtcggac atacttttga ttgtacaatt gtacatttgt atacctgtaa
     4321 tgtaaatgtg gagaagtttg aatcaacatg aacacgtttt tggtaagaag agaaccggcc
     4381 agcccgtgca ctctgtatat cccacctttt atggttgtag cagatagtgt tgtatattgt
     4441 aaattgtaat ttcaaacaga agtaaatttt tttcttttga aggaataaat gttctttata
     4501 cagcctagtt aatgtttaaa aagaaaaaat agcttggttt atttgtcagc tagtcaagac
     4561 ggtagtgaga gcctttctaa atgttacttc agatgattca gttcacacta gtgttccttt
     4621 tttttttttt atcctaagaa aaggtaatgt ttcgcttatt ttgtgacagt caaaaggatg
     4681 tgcagaagtt tcgcctgccc cttccctgct caccacctcc ccttgtaaag tgactcaccc
     4741 tccgttttgt acagatgagc tgtattttgc attttgtcta cttgtaagtg aatgtaacat
     4801 actgtcaatc ctcgtttgaa tatagactgt aacactacac ggtgtacatt tccagagcct
     4861 tgtgtatatt tccaatgaac tttttgcaag cacacttgta accatatgtg tataattaac
     4921 aaacctgtgt atgcttatgc ctgggcaact attttttgta actcttgtgt agattgtctc
     4981 taaacaatgt gtgatcttta ttttgaaaaa aatacagaac tttggaatct gaa
//
LOCUS       NM_001437091            6579 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            17, mRNA.
ACCESSION   NM_001437091 XM_039097190
VERSION     NM_001437091.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6579)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6579)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6579)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6579)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6579)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6579)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6579)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6579)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6579)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6579)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097190.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2007875.1,
                                           SRR26643285.52655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-763             JAXUCZ010000018.1  65528844-65528917
            764-967             JAXUCZ010000018.1  65531547-65531750
            968-1103            JAXUCZ010000018.1  65551334-65551469
            1104-1254           JAXUCZ010000018.1  65553405-65553555
            1255-1484           JAXUCZ010000018.1  65556812-65557041
            1485-1625           JAXUCZ010000018.1  65557878-65558018
            1626-6579           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6579
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1621
                     /gene="Tcf4"
                     /note="isoform 17 is encoded by transcript variant 17;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 17"
                     /protein_id="NP_001424020.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSGTAVWSRNGGQASSSPNYEGPLH
                     SLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYG
                     TGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRG
                     MPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLT
                     PEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVA
                     VILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    1289..1543
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1289..1543
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1313..1315,1325..1327,1331..1339,1343..1345,
                     1358..1360,1421..1426)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1313..1315,1325..1327,1331..1339,1343..1345,
                     1358..1360,1421..1426)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1352..1357,1364..1369,1373..1378,1385..1387,
                     1397..1399,1427..1429,1436..1438,1448..1450,1457..1459,
                     1466..1483)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1352..1357,1364..1369,1373..1378,1385..1387,
                     1397..1399,1427..1429,1436..1438,1448..1450,1457..1459,
                     1466..1483)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..763
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1254
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1484
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1625
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..6579
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagg cacagctgtt tggtctcgaa acggaggaca
      721 ggcctcgtca tctcccaatt acgaaggacc cttgcactcc ttgcagagcc gaattgaaga
      781 ccgtttagaa agactggacg acgcgattca tgttctccgg aaccacgcgg tgggcccatc
      841 cacagctgtg cccggtggcc atggggacat gcatgggatc atcggaccct ctcacaatgg
      901 agcaatgggc agtctgggct caggatatgg aactggcctt ctctcagcca acagacattc
      961 actcatggtc ggggcccacc gtgaagatgg cgtggcactg agaggcagcc attctctcct
     1021 gccaaaccag gttccggttc cacagcttcc agtccagtct gcaacttccc ctgacttgaa
     1081 cccaccccaa gacccttaca gagggatgcc accaggcctc cagggacaga gtgtgtcttc
     1141 cggcagctct gagatcaagt ccgacgacga gggcgatgag aacctacagg acacaaaatc
     1201 ttccgaggac aagaaactag acgacgacaa gaaggatatc aaatcaatta ctagcaataa
     1261 cgatgatgag gacctgaccc cggagcagaa ggccgagcgt gagaaggagc ggaggatggc
     1321 caataacgcc cgtgagcgcc tgagggtccg tgatatcaac gaggctttca aggagctggg
     1381 ccgcatggta cagctccacc tgaagagcga caagccccag accaagctcc tgattctcca
     1441 ccaggcagtg gctgtcatcc tcagcctgga gcagcaagtg cgagaaagga acctgaaccc
     1501 aaaagctgcc tgtctgaaaa gaagggagga agagaaggtg tcctcagagc ctcccccgct
     1561 ctccttggct ggcccacacc ctgggatggg agacgcagcg aatcacatgg gtcagatgtg
     1621 aaagggtcca agttgccacc ttgcttcatt aaaacaagag accacttcct taacagctgt
     1681 attatcctaa acccacataa acactgctcc ttaaccccgt tttttttgta atataagaca
     1741 agtctgagta gttatgaatc gcagacgcaa gaggtttcag cattcccaat tatcaaaaaa
     1801 cagaaaaaca aacacaaaaa aaaaatgaat gaaagaaaga aagaaagaga aaatgcaact
     1861 tgagggacga cttctttaac atatcactct gaatgtgcga agcggtatgt acaggctgag
     1921 acgcagccca gagactgaat ggcaatcctt ccacactgtg gagcaatgca tttgtgccta
     1981 aacttctttt ggaaaaaaaa atataattaa tttgtaagtc tgaaaaaaaa tatttaattt
     2041 aaaaaaaatt gtaaacttgc aataatgaaa aagtgtactt ctgaagaaaa acgacatgaa
     2101 cgtttttgtt ggtattcaag tcagctagtg tttctaatta ccggatattg aatagaggaa
     2161 gcccggctac cctcataaca aaaccagcaa ccgtcctgat ggcaaccgaa atgatgacat
     2221 tagccattcc ttagggtagg agggacagat ggatgttata gacctatgac aaatatatat
     2281 ataaatatat atataaatat atattaaaaa tttagtgact atggtaagct tttgttcatt
     2341 tgtttcagac ttttttctcc tgtaaaaaaa tagtactgat taactttttt aaaagaaaga
     2401 ttttactgta aatatggatt tttttttgtc tgatttttgt cccttccccc agtttgttat
     2461 cgtgacctgt agtgccaact ctgcttccgg aggggcagtg caggacgaaa tgctgaccct
     2521 gatgttgctt ctcattcata aatagtagaa agttgtttct ccagtctttt gggaacacag
     2581 gacttaaaag tcacatcatg tgtagaaatt acatgcagca ttgcccgggc aaggcaaaaa
     2641 gagtttgtct ggcttgtggc actgtgcttg ttaccctctc ctgggatttt cagaggtaca
     2701 cggttagaat gctacaatgt taccactgtg ccttccaatg tttatatcat cggaaacatg
     2761 acataatcaa agtggctgtg atttaacaaa aaaaaaaaaa gattcaagtg ttacctacct
     2821 gtgtagcgga agtagtgtgc agtgagacgt ttctgaatac atggtcagat tttttttgga
     2881 aaaaatacaa aaacaaaaaa aaaaaacaaa aaaatttaaa aaaaaaagtc aagttcaaaa
     2941 accgtcaaat gagaaaatcg caaggagtgt gacagctgat tgattttgtt gcttttcttg
     3001 attttttttt ttttgtttcc aaatgggttt actaaaaagt acatgactta cctgcctcct
     3061 ccttcgtctg aaaacaaaaa acaaaaaaac aatgccaacc tatcccacag cattatagca
     3121 agccttataa gccctaaagc attaagttgc actttggtga ggaggggtag cgcagtattc
     3181 tctctggcca gtatgagtga agtttatact taacatttga tagaaacata gatcaaactg
     3241 tggcacagta actcatcaga tagctagcgt tgactctggg cacaattgaa ccaattccca
     3301 tcctaaatct ttccaacaat tgactttggt gtacagtgca gtgaacacat agaactccta
     3361 cttaagtatt cgtcagcatc cttttgtctc taactcggtt ctgttttgac agccacacaa
     3421 tcttggcatg tattaagtaa aaaaaaaaaa aaaatccctg ttgaagtagt tttcccacct
     3481 atcagcactg agtaattgcc gtaactcaat ggaaatggtc taaacgcccc ccatctcttg
     3541 tcctgtacca ccagttacac agtgacaaaa cacatctgta aattttatgc aaccaatggc
     3601 aaacctatca ttattttgaa actgtgtatg taaaagttat atttttacat gtagactctt
     3661 gttattatgt gttttaatac attgtatcag ttttttgttt cctttttttt ttaactgtgt
     3721 ggttttaaaa agtcatttaa atgaaatagc gagctacaag aatctgaaat ttatgttcat
     3781 ttctgaaaat gtaagaacaa ataagatagt tatcacgtgg tcacctttta caaacccatc
     3841 gatgttttga ctagctgtgt gtatgtgtgt gtgtgcgcat gtgtgcgtgt gtgtgtatgt
     3901 gtgttgaaaa ctgtaaatat gttcagtagc gataaaacga caatgctttg atttgttgag
     3961 aagttcctaa aatgtggagg tggattgaaa atgtagggga atagcagaaa tcagatttca
     4021 tgaagagctc ttctcttcgg gggctttcct gtggaatggt caaacagagg tgctccaaga
     4081 agggcaagga agacagtaac ttcccctcct ccctgaacga cggaaaccat gtgtacgtgg
     4141 tctctcacca tgttaaagat tttctttccg tgatacattc tgcactcttt ttgtatagtc
     4201 taccaaggcg ggtatccctg ggaacaatat tatgatatag gaagcagtat actctgatca
     4261 cattcaggag aattgtatag aagagaatat ggtgtttact ctttagggaa ctggaaattc
     4321 tccctgcatt gatgtacatc ttcagagcgg cccttttgat acacgttatc ataaaggtgc
     4381 tgactaaagc agaattaaag tttttcaaat ctgtaaacaa agcaaaaaat taaattacag
     4441 tcattcgatt gtttgttttt ttttttttcc aattggtgct tttatatttt gttctcactc
     4501 agacagaaaa ggctgcaatt tcttgttcac cagctttgat gtattcatta ctcggtaatg
     4561 taatacggct attgtcaaat tccttttgga aataagcaaa aggcttcccc aaggcctgca
     4621 gcagctgctg gctactttct gcttggcgca gaaacatgat ctgaccctct ctgtagtaat
     4681 cgagttgtat ctccagtttt aaaaagaagg aaaaagggaa tgtggccgtt ttaatgtgtt
     4741 tttttttttc ttttcttgtt gttattttgt aattctcaaa cccaggtaag atattggtat
     4801 tcctgcactg gatttttgaa agaaacttag cagaagacag gatcgagata ctatagaagc
     4861 atttcccaag tgttcatact atactagaca taaatgataa cggcgatgta taggttcagg
     4921 atcggtttaa gagactcaga ctttgaaagc aacttggaac ggttgatcca cctccacatt
     4981 cgagtaatta ataattctgc agaattaggg atctgtccat ctaggagttg ttacccattt
     5041 gtcttctgtg tggctgcgag gaacactaac gcttttacaa ctgtcagttc acccagtggt
     5101 acaactgatt ctgactcagt cttccgattc ctgttttgta ttttgttttt ccactttttt
     5161 cctatctctt gattttattg ttgttgttat tgctattgtt attattatta ttcgtgatct
     5221 ttatttcgat gaggggttgg gaagtgggag ggagtcgaac tgagactagg ggttgagagg
     5281 atttttttgg tttggttttc ttttcttttt tttttgtttt tttttttttt tgtttgtttg
     5341 tttcatcttt gcgtccaaca ggcagaatat ggtctgtgtc caaaacggaa cttaagtcag
     5401 gaaggaaacc attcagcgta aacaagcaca acatgtagtc tgtcggctgt ctggaagcaa
     5461 aaataaatta ataaataaat aataaataag taaaagacac acacggaggt gaagatgaaa
     5521 tgtgatggat tccgagacaa tggggcacca aggcctgtag gcctcctctt gattttgctt
     5581 tggttatgtt tgttttcctt agagatgttt ttttcctcac gggacttgaa gtgactcatc
     5641 tctgtgcagt aatggtttcg ccatatgctc atttcaagta ttatagacat atgtaatggt
     5701 gaaatatatg aactgtggcc tttttcattc ttgttatttg tgatgcaatt aagtgaagag
     5761 aagaaaaaaa aaagcagaga tttaccatgt atcagtgcct ggctttttgt tataaagctt
     5821 cgtctgtcta gtgctctttt tgctataaaa atagactgta gtacacccta gtaggaaaaa
     5881 aaaaccctaa atttaaaaat aaaaaaatat atttggctta tttttcgcag gagcaatcct
     5941 tttataccat ggatattaca aaaaaaaaaa ttgtcagatt ctgaatattt cttctttgta
     6001 gatttttgga atcattataa gtaaaagttt gttactttat tttactattt aaaagatgtt
     6061 attttgccat gtgttactga gatgaaactg tatggtatag cttcttctgt tcgttttttg
     6121 tttccggttt tttgtttgtt cgtttttggt tttttttttt tttgtttgtt tgttttgttt
     6181 tgtttttttt tcttagttgt aggtcgcagt aaggactttt ccttttgttt ttgttttttc
     6241 gttatgtttt gttttgtttt tgcgactgta cacatagctg cagcattaaa aacttttaaa
     6301 aaaatctgtt aaaaaaaaaa gaaaaaaaag ggaaaacgtt taaaaaaaaa agataaacag
     6361 ttacaccttg ttttcaacgt gtggctgagt gcctcgattt tttcatgttt ttggtgtatt
     6421 tctgatttgt agaagtgtcc aaacaggttg tgtcctggac ttccttcaag aggcgaacaa
     6481 cccagcttgg tctaggccat gacctgttcc catctgtagt tactcgatga agtcatgtac
     6541 atgaccgttc tgtagcaata aatgtgccat ttttataaa
//
LOCUS       NM_001437078            5315 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 6, mRNA.
ACCESSION   NM_001437078 XM_006239033
VERSION     NM_001437078.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5315)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5315)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5315)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5315)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5315)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5315)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5315)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5315)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5315)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5315)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006239033.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21068.1,
                                           SRR26643295.22933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1467           JAXUCZ010000005.1  148197680-148197781
            1468-1619           JAXUCZ010000005.1  148200975-148201126
            1620-1758           JAXUCZ010000005.1  148203568-148203706
            1759-1902           JAXUCZ010000005.1  148205552-148205695
            1903-2199           JAXUCZ010000005.1  148206678-148206974
            2200-2436           JAXUCZ010000005.1  148208059-148208295
            2437-2704           JAXUCZ010000005.1  148218465-148218732
            2705-2834           JAXUCZ010000005.1  148219783-148219912
            2835-2963           JAXUCZ010000005.1  148221617-148221745
            2964-3101           JAXUCZ010000005.1  148225153-148225290
            3102-3227           JAXUCZ010000005.1  148228732-148228857
            3228-3349           JAXUCZ010000005.1  148229514-148229635
            3350-3542           JAXUCZ010000005.1  148231206-148231398
            3543-5315           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5315
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3674
                     /gene="Pum1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 6"
                     /protein_id="NP_001424007.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAAT
                     LGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGA
                     SQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALV
                     VNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLG
                     TQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLG
                     ATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSSS
                     PGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSA
                     SSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEF
                     SQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQK
                     LALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNH
                     VVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELH
                     QHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTH
                     ASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRP
                     HIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2640..3605
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2640..3605
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2808..2813,2820..2822,2916..2921,2928..2930,
                     3027..3029,3036..3038,3132..3137,3144..3146,3231..3236,
                     3240..3245,3252..3254,3339..3344,3348..3353,3360..3362,
                     3468..3473,3477..3482,3489..3491,3579..3581,3588..3590)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2808..2813,2820..2822,2916..2921,2928..2930,
                     3027..3029,3036..3038,3132..3137,3144..3146,3231..3236,
                     3240..3245,3252..3254,3339..3344,3348..3353,3360..3362,
                     3468..3473,3477..3482,3489..3491,3579..3581,3588..3590)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1619
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1758
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1902
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2199
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2436
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2704
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2834
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2963
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3101
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3227
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3349
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3542
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..5315
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggttta gctcccgctg
     1381 cgtttgtccc caacccatac atcatcagcg ctgctccccc agggacggac ccctacacag
     1441 ctggattggc tgcagcagcg acactcggcc cagctgtggt ccctcaccaa tattatggag
     1501 tcacgccatg gggtgtctat cctgctagtc ttttccagca acaagctgct gcagctgcag
     1561 cagcaacaaa ttcagctact cagcagagtg ccccacaggc ccagcaggga cagcagcagg
     1621 ttcttcgtgg aggagctagc cagcgtcctt tgaccccaaa tcagaaccag cagggacaac
     1681 aaacagatcc ccttgtagca gctgcagcag tgaactctgc tcttgccttt ggacaaggat
     1741 tggctgcagg tatgccaggt tatccagtct tggcacctgc tgcttactat gaccaaactg
     1801 gtgcccttgt ggtgaatgca ggggcaagaa atggcctcgg agctccagtt cggcttgttg
     1861 ctccagcccc agtcatcatt agctcctcag ctgcacaagc agctgttgca gcggctgcag
     1921 cttcagcaaa tggagcagcc ggtggtcttg caggaactac aaatggacca tttcgacctt
     1981 taggcaccca gcagccccag ccccagcccc agcagcagcc cagtaacaat ctggcttcca
     2041 gctctttcta tggcaacaac tctctgagca gtaactccca gagcagctcc ctcttctctc
     2101 agggctccgc ccagcctgcc aacacgtcct tgggattcgg aagcagcagt tcccttggtg
     2161 ccaccctagg atcggccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca
     2221 gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca
     2281 gcttggcccc cattggacac agtttttata acagccttag cttttcctcc tctcctggac
     2341 ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc
     2401 tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaac ggcagtggaa
     2461 gatacatctc tgctgctcct ggtgccgaag ccaagtaccg cagtgcgagc agtgcctcca
     2521 gccttttcag ccccagcagc accctttttt cttcctctcg tttgagatac ggaatgtctg
     2581 atgttatgcc ctctggcagg agcagacttc tggaagactt tcgaaacaac cggtacccta
     2641 atttacaact gcgggagatt gccgggcata taatggaatt ttcccaagac cagcatggtt
     2701 ctagattcat tcagctgaaa ctagagcgag ccacagcagc tgagcgccag cttgtcttca
     2761 acgaaatcct gcaggctgcg taccaactta tggtggatgt gtttggaaat tacgtcattc
     2821 agaagttctt tgaatttggc agccatgaac agaagctggc tttggctgaa cggattcgag
     2881 gccacgtcct atcattggca ctgcagatgt atggctgccg agtcatccag aaagctttgg
     2941 aatttattcc ctcagaccag cagaacgaga tggtgcggga gctagatggc catgtcctga
     3001 agtgtgtgaa agaccagaat ggcaaccatg tggttcagaa gtgcattgaa tgtgtacagc
     3061 cccagtcttt gcagttcatc atcgatgcat tcaaggggca ggtgtttgct ttgtctacgc
     3121 acccatatgg ctgtagggtg atccagagga tcctggaaca ctgtctcccc gaccagaccc
     3181 tccctatcct ggaggagctt caccagcaca cggagcagct cgtgcaggat cagtatggaa
     3241 attatgtaat ccaacatgtc ctggagcatg gtcgtcctga ggataaaagc aaaattgtag
     3301 cagagatccg aggcaatgta cttgtattga gtcagcacaa attcgcaagc aatgttgtgg
     3361 agaagtgtgt cactcacgcc tcacgtacag agcgtgctgt gctcattgat gaggtatgca
     3421 ccatgaatga cggtccccac agtgccttat acaccatgat gaaggatcag tatgccaatt
     3481 atgtggtcca gaagatgatc gatgtggctg agccggggca gcggaagatt gtcatgcaca
     3541 agatccggcc acacatcgcg actcttcgga agtacaccta tggcaagcac atcctggcca
     3601 agcttgagaa gtactacatg aagaatggtg tggacttggg gcccatttgt ggtcccccta
     3661 atgggatcat ctgagcagtg cacccatccc tgtcccgctg acctcactga ccctggcaga
     3721 tccaaccagc aaccagagat gcccagctca gagtcgaaag tgggcgatgg ttgctccggg
     3781 attgctccct cctccaaaaa tggaatcgga tccacttgtg gaaaggcctt tgtaaatttc
     3841 attttattac acataacatg tactaattat tttttttaat tgactaattg ccctgctgtt
     3901 tactggtgta taggaacttg tacataggta atcagtgtac atgagaggcc acatgctttg
     3961 ttcaatgttg tatctatatt ccacatgtgg acactttcag ggtggttggt ttaacaaaaa
     4021 aagttttaaa aaaagacaaa aaaaggtttt taactcattt gccttgtggc aagttttgca
     4081 aatagctctt ccccacccca ttttattaaa aaaagaaacc tgagaaattt gaattttagt
     4141 taaataatct caaactggca tttaacactg tttataaaat atatatatat atatacatat
     4201 atacatatga aatgggaacg tttccgagtt gctaaagcat cagcctgtga tacggagttt
     4261 atgacgctct ttggagatga cctcatgctg agggaggtgg tagctgcaga tccaggagga
     4321 gcgggaagca cagagacagg ccggaggcca gtgggcatgg ccacttgctc tatgggttgc
     4381 cttctgtgaa cactgggaag cagaatctga ttatctagca tgagagaacc cagctctgct
     4441 cctggtctgg cttctataga tacatagtgt atacttgtgt agactttgca tatatacgga
     4501 tttgtagtat tttcctgttt tgatgtctaa tctgtatcta taatgtaccc tagtagtcgg
     4561 acatactttt gattgtacaa ttgtacattt gtatacctgt aatgtaaatg tggagaagtt
     4621 tgaatcaaca tgaacacgtt tttggtaaga agagaaccgg ccagcccgtg cactctgtat
     4681 atcccacctt ttatggttgt agcagatagt gttgtatatt gtaaattgta atttcaaaca
     4741 gaagtaaatt tttttctttt gaaggaataa atgttcttta tacagcctag ttaatgttta
     4801 aaaagaaaaa atagcttggt ttatttgtca gctagtcaag acggtagtga gagcctttct
     4861 aaatgttact tcagatgatt cagttcacac tagtgttcct tttttttttt ttatcctaag
     4921 aaaaggtaat gtttcgctta ttttgtgaca gtcaaaagga tgtgcagaag tttcgcctgc
     4981 cccttccctg ctcaccacct ccccttgtaa agtgactcac cctccgtttt gtacagatga
     5041 gctgtatttt gcattttgtc tacttgtaag tgaatgtaac atactgtcaa tcctcgtttg
     5101 aatatagact gtaacactac acggtgtaca tttccagagc cttgtgtata tttccaatga
     5161 actttttgca agcacacttg taaccatatg tgtataatta acaaacctgt gtatgcttat
     5221 gcctgggcaa ctattttttg taactcttgt gtagattgtc tctaaacaat gtgtgatctt
     5281 tattttgaaa aaaatacaga actttggaat ctgaa
//
LOCUS       NM_001437077            6787 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            11, mRNA.
ACCESSION   NM_001437077 XM_063277628
VERSION     NM_001437077.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6787)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6787)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6787)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6787)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6787)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6787)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6787)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6787)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6787)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6787)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277628.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.358023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000018.1  65393129-65393325
            198-327             JAXUCZ010000018.1  65437939-65438068
            328-377             JAXUCZ010000018.1  65438528-65438577
            378-483             JAXUCZ010000018.1  65507173-65507278
            484-614             JAXUCZ010000018.1  65511025-65511155
            615-747             JAXUCZ010000018.1  65516916-65517048
            748-815             JAXUCZ010000018.1  65525175-65525242
            816-894             JAXUCZ010000018.1  65526319-65526397
            895-971             JAXUCZ010000018.1  65528841-65528917
            972-1175            JAXUCZ010000018.1  65531547-65531750
            1176-1311           JAXUCZ010000018.1  65551334-65551469
            1312-1462           JAXUCZ010000018.1  65553405-65553555
            1463-1692           JAXUCZ010000018.1  65556812-65557041
            1693-1833           JAXUCZ010000018.1  65557878-65558018
            1834-6787           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6787
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..197
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    75..77
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            198..327
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1829
                     /gene="Tcf4"
                     /note="isoform 11 is encoded by transcript variant 11;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 11"
                     /protein_id="NP_001424006.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVR
                     KVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSG
                     MNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHY
                     STSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPV
                     GSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGP
                     STAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSH
                     SLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENL
                     QDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDIN
                     EAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEE
                     KVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    234..>719
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    234..>719
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1497..1751
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1497..1751
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1521..1523,1533..1535,1539..1547,1551..1553,
                     1566..1568,1629..1634)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1521..1523,1533..1535,1539..1547,1551..1553,
                     1566..1568,1629..1634)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1560..1565,1572..1577,1581..1586,1593..1595,
                     1605..1607,1635..1637,1644..1646,1656..1658,1665..1667,
                     1674..1691)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1560..1565,1572..1577,1581..1586,1593..1595,
                     1605..1607,1635..1637,1644..1646,1656..1658,1665..1667,
                     1674..1691)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            328..377
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            378..483
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            484..614
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..747
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..815
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..894
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..971
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1175
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1311
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1462
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1692
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1833
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..6787
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattttaaa agttgactcc tctggtccag ttgccaattc agtcatctcc cagcatctaa
       61 aagattcgtg gcgatgagct gcacagctct tggttgagaa gtcttccagg agggcagccc
      121 atggcagttt gtgtggaaag aattctgcag ggaagaaatt tacagccatt ctggtgcaac
      181 gggaacatct ttggaatcag agtctcctcg gaggggacat ggatatgggc aacccaggaa
      241 ccctttcgcc caccaaacct ggctcccagt actacccata ttccagcaat aacgcccgac
      301 ggaggcctct tcacagtagt accatggagg tgcagacaaa gaaagtcaga aaagttcctc
      361 caggcttgcc atcttcagtc tacgctcctt cagccagcac tgccgactac aacagggact
      421 caccaggcta ttcttcctcc aagccagcag ccagcacttt ctccagctcc ttcttcatgc
      481 aagatggcca tcacagcagt gacccttgga gctcctccag tggaatgaat cagcccggct
      541 atggagggat gctaggcaac tctcatatcc cacagtctag cagctactgt agcctgcatc
      601 cacatgaacg tctgagctat ccatcgcact cctcggcaga catcaactcc agtcttcctc
      661 cgatgtccac gttccatcga agtggcacaa accattacag cacctcttcc tgcacacctc
      721 ctgccaacgg aacagacagt ataatggcaa acagaggaac tggggcagca ggcagctccc
      781 agactggaga cgctctgggg aaagccctgg cttcgatcta ttctcctgat cacacgaaca
      841 acagcttctc ctccaaccct tcaactcctg ttggctcccc tccttcactc tcagcaggca
      901 cagctgtttg gtctcgaaac ggaggacagg cctcgtcatc tcccaattac gaaggaccct
      961 tgcactcctt gcagagccga attgaagacc gtttagaaag actggacgac gcgattcatg
     1021 ttctccggaa ccacgcggtg ggcccatcca cagctgtgcc cggtggccat ggggacatgc
     1081 atgggatcat cggaccctct cacaatggag caatgggcag tctgggctca ggatatggaa
     1141 ctggccttct ctcagccaac agacattcac tcatggtcgg ggcccaccgt gaagatggcg
     1201 tggcactgag aggcagccat tctctcctgc caaaccaggt tccggttcca cagcttccag
     1261 tccagtctgc aacttcccct gacttgaacc caccccaaga cccttacaga gggatgccac
     1321 caggcctcca gggacagagt gtgtcttccg gcagctctga gatcaagtcc gacgacgagg
     1381 gcgatgagaa cctacaggac acaaaatctt ccgaggacaa gaaactagac gacgacaaga
     1441 aggatatcaa atcaattact agcaataacg atgatgagga cctgaccccg gagcagaagg
     1501 ccgagcgtga gaaggagcgg aggatggcca ataacgcccg tgagcgcctg agggtccgtg
     1561 atatcaacga ggctttcaag gagctgggcc gcatggtaca gctccacctg aagagcgaca
     1621 agccccagac caagctcctg attctccacc aggcagtggc tgtcatcctc agcctggagc
     1681 agcaagtgcg agaaaggaac ctgaacccaa aagctgcctg tctgaaaaga agggaggaag
     1741 agaaggtgtc ctcagagcct cccccgctct ccttggctgg cccacaccct gggatgggag
     1801 acgcagcgaa tcacatgggt cagatgtgaa agggtccaag ttgccacctt gcttcattaa
     1861 aacaagagac cacttcctta acagctgtat tatcctaaac ccacataaac actgctcctt
     1921 aaccccgttt tttttgtaat ataagacaag tctgagtagt tatgaatcgc agacgcaaga
     1981 ggtttcagca ttcccaatta tcaaaaaaca gaaaaacaaa cacaaaaaaa aaatgaatga
     2041 aagaaagaaa gaaagagaaa atgcaacttg agggacgact tctttaacat atcactctga
     2101 atgtgcgaag cggtatgtac aggctgagac gcagcccaga gactgaatgg caatccttcc
     2161 acactgtgga gcaatgcatt tgtgcctaaa cttcttttgg aaaaaaaaat ataattaatt
     2221 tgtaagtctg aaaaaaaata tttaatttaa aaaaaattgt aaacttgcaa taatgaaaaa
     2281 gtgtacttct gaagaaaaac gacatgaacg tttttgttgg tattcaagtc agctagtgtt
     2341 tctaattacc ggatattgaa tagaggaagc ccggctaccc tcataacaaa accagcaacc
     2401 gtcctgatgg caaccgaaat gatgacatta gccattcctt agggtaggag ggacagatgg
     2461 atgttataga cctatgacaa atatatatat aaatatatat ataaatatat attaaaaatt
     2521 tagtgactat ggtaagcttt tgttcatttg tttcagactt ttttctcctg taaaaaaata
     2581 gtactgatta acttttttaa aagaaagatt ttactgtaaa tatggatttt tttttgtctg
     2641 atttttgtcc cttcccccag tttgttatcg tgacctgtag tgccaactct gcttccggag
     2701 gggcagtgca ggacgaaatg ctgaccctga tgttgcttct cattcataaa tagtagaaag
     2761 ttgtttctcc agtcttttgg gaacacagga cttaaaagtc acatcatgtg tagaaattac
     2821 atgcagcatt gcccgggcaa ggcaaaaaga gtttgtctgg cttgtggcac tgtgcttgtt
     2881 accctctcct gggattttca gaggtacacg gttagaatgc tacaatgtta ccactgtgcc
     2941 ttccaatgtt tatatcatcg gaaacatgac ataatcaaag tggctgtgat ttaacaaaaa
     3001 aaaaaaaaga ttcaagtgtt acctacctgt gtagcggaag tagtgtgcag tgagacgttt
     3061 ctgaatacat ggtcagattt tttttggaaa aaatacaaaa acaaaaaaaa aaaacaaaaa
     3121 aatttaaaaa aaaaagtcaa gttcaaaaac cgtcaaatga gaaaatcgca aggagtgtga
     3181 cagctgattg attttgttgc ttttcttgat tttttttttt ttgtttccaa atgggtttac
     3241 taaaaagtac atgacttacc tgcctcctcc ttcgtctgaa aacaaaaaac aaaaaaacaa
     3301 tgccaaccta tcccacagca ttatagcaag ccttataagc cctaaagcat taagttgcac
     3361 tttggtgagg aggggtagcg cagtattctc tctggccagt atgagtgaag tttatactta
     3421 acatttgata gaaacataga tcaaactgtg gcacagtaac tcatcagata gctagcgttg
     3481 actctgggca caattgaacc aattcccatc ctaaatcttt ccaacaattg actttggtgt
     3541 acagtgcagt gaacacatag aactcctact taagtattcg tcagcatcct tttgtctcta
     3601 actcggttct gttttgacag ccacacaatc ttggcatgta ttaagtaaaa aaaaaaaaaa
     3661 aatccctgtt gaagtagttt tcccacctat cagcactgag taattgccgt aactcaatgg
     3721 aaatggtcta aacgcccccc atctcttgtc ctgtaccacc agttacacag tgacaaaaca
     3781 catctgtaaa ttttatgcaa ccaatggcaa acctatcatt attttgaaac tgtgtatgta
     3841 aaagttatat ttttacatgt agactcttgt tattatgtgt tttaatacat tgtatcagtt
     3901 ttttgtttcc tttttttttt aactgtgtgg ttttaaaaag tcatttaaat gaaatagcga
     3961 gctacaagaa tctgaaattt atgttcattt ctgaaaatgt aagaacaaat aagatagtta
     4021 tcacgtggtc accttttaca aacccatcga tgttttgact agctgtgtgt atgtgtgtgt
     4081 gtgcgcatgt gtgcgtgtgt gtgtatgtgt gttgaaaact gtaaatatgt tcagtagcga
     4141 taaaacgaca atgctttgat ttgttgagaa gttcctaaaa tgtggaggtg gattgaaaat
     4201 gtaggggaat agcagaaatc agatttcatg aagagctctt ctcttcgggg gctttcctgt
     4261 ggaatggtca aacagaggtg ctccaagaag ggcaaggaag acagtaactt cccctcctcc
     4321 ctgaacgacg gaaaccatgt gtacgtggtc tctcaccatg ttaaagattt tctttccgtg
     4381 atacattctg cactcttttt gtatagtcta ccaaggcggg tatccctggg aacaatatta
     4441 tgatatagga agcagtatac tctgatcaca ttcaggagaa ttgtatagaa gagaatatgg
     4501 tgtttactct ttagggaact ggaaattctc cctgcattga tgtacatctt cagagcggcc
     4561 cttttgatac acgttatcat aaaggtgctg actaaagcag aattaaagtt tttcaaatct
     4621 gtaaacaaag caaaaaatta aattacagtc attcgattgt ttgttttttt ttttttccaa
     4681 ttggtgcttt tatattttgt tctcactcag acagaaaagg ctgcaatttc ttgttcacca
     4741 gctttgatgt attcattact cggtaatgta atacggctat tgtcaaattc cttttggaaa
     4801 taagcaaaag gcttccccaa ggcctgcagc agctgctggc tactttctgc ttggcgcaga
     4861 aacatgatct gaccctctct gtagtaatcg agttgtatct ccagttttaa aaagaaggaa
     4921 aaagggaatg tggccgtttt aatgtgtttt tttttttctt ttcttgttgt tattttgtaa
     4981 ttctcaaacc caggtaagat attggtattc ctgcactgga tttttgaaag aaacttagca
     5041 gaagacagga tcgagatact atagaagcat ttcccaagtg ttcatactat actagacata
     5101 aatgataacg gcgatgtata ggttcaggat cggtttaaga gactcagact ttgaaagcaa
     5161 cttggaacgg ttgatccacc tccacattcg agtaattaat aattctgcag aattagggat
     5221 ctgtccatct aggagttgtt acccatttgt cttctgtgtg gctgcgagga acactaacgc
     5281 ttttacaact gtcagttcac ccagtggtac aactgattct gactcagtct tccgattcct
     5341 gttttgtatt ttgtttttcc acttttttcc tatctcttga ttttattgtt gttgttattg
     5401 ctattgttat tattattatt cgtgatcttt atttcgatga ggggttggga agtgggaggg
     5461 agtcgaactg agactagggg ttgagaggat ttttttggtt tggttttctt ttcttttttt
     5521 tttgtttttt tttttttttg tttgtttgtt tcatctttgc gtccaacagg cagaatatgg
     5581 tctgtgtcca aaacggaact taagtcagga aggaaaccat tcagcgtaaa caagcacaac
     5641 atgtagtctg tcggctgtct ggaagcaaaa ataaattaat aaataaataa taaataagta
     5701 aaagacacac acggaggtga agatgaaatg tgatggattc cgagacaatg gggcaccaag
     5761 gcctgtaggc ctcctcttga ttttgctttg gttatgtttg ttttccttag agatgttttt
     5821 ttcctcacgg gacttgaagt gactcatctc tgtgcagtaa tggtttcgcc atatgctcat
     5881 ttcaagtatt atagacatat gtaatggtga aatatatgaa ctgtggcctt tttcattctt
     5941 gttatttgtg atgcaattaa gtgaagagaa gaaaaaaaaa agcagagatt taccatgtat
     6001 cagtgcctgg ctttttgtta taaagcttcg tctgtctagt gctctttttg ctataaaaat
     6061 agactgtagt acaccctagt aggaaaaaaa aaccctaaat ttaaaaataa aaaaatatat
     6121 ttggcttatt tttcgcagga gcaatccttt tataccatgg atattacaaa aaaaaaaatt
     6181 gtcagattct gaatatttct tctttgtaga tttttggaat cattataagt aaaagtttgt
     6241 tactttattt tactatttaa aagatgttat tttgccatgt gttactgaga tgaaactgta
     6301 tggtatagct tcttctgttc gttttttgtt tccggttttt tgtttgttcg tttttggttt
     6361 tttttttttt tgtttgtttg ttttgttttg tttttttttc ttagttgtag gtcgcagtaa
     6421 ggacttttcc ttttgttttt gttttttcgt tatgttttgt tttgtttttg cgactgtaca
     6481 catagctgca gcattaaaaa cttttaaaaa aatctgttaa aaaaaaaaga aaaaaaaggg
     6541 aaaacgttta aaaaaaaaag ataaacagtt acaccttgtt ttcaacgtgt ggctgagtgc
     6601 ctcgattttt tcatgttttt ggtgtatttc tgatttgtag aagtgtccaa acaggttgtg
     6661 tcctggactt ccttcaagag gcgaacaacc cagcttggtc taggccatga cctgttccca
     6721 tctgtagtta ctcgatgaag tcatgtacat gaccgttctg tagcaataaa tgtgccattt
     6781 ttataaa
//
LOCUS       NM_001437075            5330 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 3, mRNA.
ACCESSION   NM_001437075 XM_006239031
VERSION     NM_001437075.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5330)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5330)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5330)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5330)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5330)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5330)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5330)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5330)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5330)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006239031.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.30487.1,
                                           SRR26360176.502459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1482           JAXUCZ010000005.1  148197665-148197781
            1483-1634           JAXUCZ010000005.1  148200975-148201126
            1635-1773           JAXUCZ010000005.1  148203568-148203706
            1774-1917           JAXUCZ010000005.1  148205552-148205695
            1918-2214           JAXUCZ010000005.1  148206678-148206974
            2215-2451           JAXUCZ010000005.1  148208059-148208295
            2452-2719           JAXUCZ010000005.1  148218465-148218732
            2720-2849           JAXUCZ010000005.1  148219783-148219912
            2850-2978           JAXUCZ010000005.1  148221617-148221745
            2979-3116           JAXUCZ010000005.1  148225153-148225290
            3117-3242           JAXUCZ010000005.1  148228732-148228857
            3243-3364           JAXUCZ010000005.1  148229514-148229635
            3365-3557           JAXUCZ010000005.1  148231206-148231398
            3558-5330           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5330
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3689
                     /gene="Pum1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 3"
                     /protein_id="NP_001424004.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGMFPAGLAPAAFVPNPYIISAAPPGTDPYTAGL
                     AAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQV
                     LRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQ
                     TGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGP
                     FRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGS
                     SSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSL
                     SFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEA
                     KYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAG
                     HIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFG
                     SHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKD
                     QNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPI
                     LEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVE
                     KCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVM
                     HKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2655..3620
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2655..3620
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2823..2828,2835..2837,2931..2936,2943..2945,
                     3042..3044,3051..3053,3147..3152,3159..3161,3246..3251,
                     3255..3260,3267..3269,3354..3359,3363..3368,3375..3377,
                     3483..3488,3492..3497,3504..3506,3594..3596,3603..3605)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2823..2828,2835..2837,2931..2936,2943..2945,
                     3042..3044,3051..3053,3147..3152,3159..3161,3246..3251,
                     3255..3260,3267..3269,3354..3359,3363..3368,3375..3377,
                     3483..3488,3492..3497,3504..3506,3594..3596,3603..3605)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1482
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1634
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1773
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1917
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2214
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2451
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2719
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2849
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2978
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3116
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3242
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3364
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3557
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..5330
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggtatg tttccagcag
     1381 gtttagctcc cgctgcgttt gtccccaacc catacatcat cagcgctgct cccccaggga
     1441 cggaccccta cacagctgga ttggctgcag cagcgacact cggcccagct gtggtccctc
     1501 accaatatta tggagtcacg ccatggggtg tctatcctgc tagtcttttc cagcaacaag
     1561 ctgctgcagc tgcagcagca acaaattcag ctactcagca gagtgcccca caggcccagc
     1621 agggacagca gcaggttctt cgtggaggag ctagccagcg tcctttgacc ccaaatcaga
     1681 accagcaggg acaacaaaca gatccccttg tagcagctgc agcagtgaac tctgctcttg
     1741 cctttggaca aggattggct gcaggtatgc caggttatcc agtcttggca cctgctgctt
     1801 actatgacca aactggtgcc cttgtggtga atgcaggggc aagaaatggc ctcggagctc
     1861 cagttcggct tgttgctcca gccccagtca tcattagctc ctcagctgca caagcagctg
     1921 ttgcagcggc tgcagcttca gcaaatggag cagccggtgg tcttgcagga actacaaatg
     1981 gaccatttcg acctttaggc acccagcagc cccagcccca gccccagcag cagcccagta
     2041 acaatctggc ttccagctct ttctatggca acaactctct gagcagtaac tcccagagca
     2101 gctccctctt ctctcagggc tccgcccagc ctgccaacac gtccttggga ttcggaagca
     2161 gcagttccct tggtgccacc ctaggatcgg cccttggagg gtttggaaca gcagttgcaa
     2221 actccaacac tggcagtggc tcccgccgtg actccctgac tggcagcagt gacctttata
     2281 agaggacatc gagcagcttg gcccccattg gacacagttt ttataacagc cttagctttt
     2341 cctcctctcc tggacccgtg ggcatgcctc tccctagtca gggaccagga cattcacaga
     2401 caccacctcc ttccctctct tcacatggat cctcttcaag cttaaacctg ggaggactca
     2461 cgaacggcag tggaagatac atctctgctg ctcctggtgc cgaagccaag taccgcagtg
     2521 cgagcagtgc ctccagcctt ttcagcccca gcagcaccct tttttcttcc tctcgtttga
     2581 gatacggaat gtctgatgtt atgccctctg gcaggagcag acttctggaa gactttcgaa
     2641 acaaccggta ccctaattta caactgcggg agattgccgg gcatataatg gaattttccc
     2701 aagaccagca tggttctaga ttcattcagc tgaaactaga gcgagccaca gcagctgagc
     2761 gccagcttgt cttcaacgaa atcctgcagg ctgcgtacca acttatggtg gatgtgtttg
     2821 gaaattacgt cattcagaag ttctttgaat ttggcagcca tgaacagaag ctggctttgg
     2881 ctgaacggat tcgaggccac gtcctatcat tggcactgca gatgtatggc tgccgagtca
     2941 tccagaaagc tttggaattt attccctcag accagcagaa cgagatggtg cgggagctag
     3001 atggccatgt cctgaagtgt gtgaaagacc agaatggcaa ccatgtggtt cagaagtgca
     3061 ttgaatgtgt acagccccag tctttgcagt tcatcatcga tgcattcaag gggcaggtgt
     3121 ttgctttgtc tacgcaccca tatggctgta gggtgatcca gaggatcctg gaacactgtc
     3181 tccccgacca gaccctccct atcctggagg agcttcacca gcacacggag cagctcgtgc
     3241 aggatcagta tggaaattat gtaatccaac atgtcctgga gcatggtcgt cctgaggata
     3301 aaagcaaaat tgtagcagag atccgaggca atgtacttgt attgagtcag cacaaattcg
     3361 caagcaatgt tgtggagaag tgtgtcactc acgcctcacg tacagagcgt gctgtgctca
     3421 ttgatgaggt atgcaccatg aatgacggtc cccacagtgc cttatacacc atgatgaagg
     3481 atcagtatgc caattatgtg gtccagaaga tgatcgatgt ggctgagccg gggcagcgga
     3541 agattgtcat gcacaagatc cggccacaca tcgcgactct tcggaagtac acctatggca
     3601 agcacatcct ggccaagctt gagaagtact acatgaagaa tggtgtggac ttggggccca
     3661 tttgtggtcc ccctaatggg atcatctgag cagtgcaccc atccctgtcc cgctgacctc
     3721 actgaccctg gcagatccaa ccagcaacca gagatgccca gctcagagtc gaaagtgggc
     3781 gatggttgct ccgggattgc tccctcctcc aaaaatggaa tcggatccac ttgtggaaag
     3841 gcctttgtaa atttcatttt attacacata acatgtacta attatttttt ttaattgact
     3901 aattgccctg ctgtttactg gtgtatagga acttgtacat aggtaatcag tgtacatgag
     3961 aggccacatg ctttgttcaa tgttgtatct atattccaca tgtggacact ttcagggtgg
     4021 ttggtttaac aaaaaaagtt ttaaaaaaag acaaaaaaag gtttttaact catttgcctt
     4081 gtggcaagtt ttgcaaatag ctcttcccca ccccatttta ttaaaaaaag aaacctgaga
     4141 aatttgaatt ttagttaaat aatctcaaac tggcatttaa cactgtttat aaaatatata
     4201 tatatatata catatataca tatgaaatgg gaacgtttcc gagttgctaa agcatcagcc
     4261 tgtgatacgg agtttatgac gctctttgga gatgacctca tgctgaggga ggtggtagct
     4321 gcagatccag gaggagcggg aagcacagag acaggccgga ggccagtggg catggccact
     4381 tgctctatgg gttgccttct gtgaacactg ggaagcagaa tctgattatc tagcatgaga
     4441 gaacccagct ctgctcctgg tctggcttct atagatacat agtgtatact tgtgtagact
     4501 ttgcatatat acggatttgt agtattttcc tgttttgatg tctaatctgt atctataatg
     4561 taccctagta gtcggacata cttttgattg tacaattgta catttgtata cctgtaatgt
     4621 aaatgtggag aagtttgaat caacatgaac acgtttttgg taagaagaga accggccagc
     4681 ccgtgcactc tgtatatccc accttttatg gttgtagcag atagtgttgt atattgtaaa
     4741 ttgtaatttc aaacagaagt aaattttttt cttttgaagg aataaatgtt ctttatacag
     4801 cctagttaat gtttaaaaag aaaaaatagc ttggtttatt tgtcagctag tcaagacggt
     4861 agtgagagcc tttctaaatg ttacttcaga tgattcagtt cacactagtg ttcctttttt
     4921 tttttttatc ctaagaaaag gtaatgtttc gcttattttg tgacagtcaa aaggatgtgc
     4981 agaagtttcg cctgcccctt ccctgctcac cacctcccct tgtaaagtga ctcaccctcc
     5041 gttttgtaca gatgagctgt attttgcatt ttgtctactt gtaagtgaat gtaacatact
     5101 gtcaatcctc gtttgaatat agactgtaac actacacggt gtacatttcc agagccttgt
     5161 gtatatttcc aatgaacttt ttgcaagcac acttgtaacc atatgtgtat aattaacaaa
     5221 cctgtgtatg cttatgcctg ggcaactatt ttttgtaact cttgtgtaga ttgtctctaa
     5281 acaatgtgtg atctttattt tgaaaaaaat acagaacttt ggaatctgaa
//
LOCUS       NM_001437026            2411 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 12, mRNA.
ACCESSION   NM_001437026 XM_039094456
VERSION     NM_001437026.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039094456.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2454217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-248             JAXUCZ010000016.1  6871919-6872020
            249-527             JAXUCZ010000016.1  6893598-6893876
            528-786             JAXUCZ010000016.1  6894275-6894533
            787-936             JAXUCZ010000016.1  6898222-6898371
            937-2411            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2411
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            249..527
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    442..444
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            528..786
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..2109
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 12; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423955.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     544..618
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     619..2106
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    649..1560
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    649..1560
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(811..813,1111..1113,1123..1125,1129..1131,
                     1210..1215,1219..1224,1288..1290)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(811..813,1111..1113,1123..1125,1129..1131,
                     1210..1215,1219..1224,1288..1290)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(811..813,1111..1113,1210..1212)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(811..813,1111..1113,1210..1212)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    925..927
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    1084..1086
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(1114..1128,1147..1155,1213..1215,1219..1233,
                     1240..1245,1306..1311,1315..1323,1327..1332,1402..1407,
                     1546..1560)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(1114..1128,1147..1155,1213..1215,1219..1233,
                     1240..1245,1306..1311,1315..1323,1327..1332,1402..1407,
                     1546..1560)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1654..2103
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1654..2103
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1681..1683
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            787..936
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            937..2411
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaccc atgcttaact agatttctca tgcagcccag
      181 gccctccagc actggttaat agtcatcttc attcgtccct cgaagacgtg cccacagacc
      241 agcccaacaa aatcccatgt taccactatg agaaggattt tctttccaaa gcggtacgtc
      301 cttaagcaag tgattcggag tagcagacaa agcagaaaac agtgaaagcc gtgtgcggga
      361 ctctgacagg gagacttctt tatggctgcc ctgtgggtga cacagcagat gctagaattc
      421 caaaccgccc caaataaaaa ctgaagaata tcggctagga agctgccctg cgttcgggag
      481 cctcaggacc atcgcggctg tcctagaggg ctgacctgca atgctatatt tacggtctgc
      541 attatgtctg gagcccgcac tgcgcatgcg ctcgtcttcc tcctcggctg ttctgcgctt
      601 gcgttgggcg tctgctcagc ctccctggag cacggcgagg ctgagtacta cgtggctgcc
      661 gtgtacgaac accgatcggt cctgagccca aaccccctgg agctcagcag ccgccagcag
      721 gccctggagc tcatgaagca gaacctcgac gtctatgaac agcaagtgat ggctgcagcc
      781 cagaagggtg cgcacattat agtgttccca gaagacggta tccacggatt caacttcaca
      841 agaacatcca tttacccatt cttggacttg atgccatctc ccaggctggt cagttggaac
      901 ccgtgtctgg agccctttcg cttcaatgac acggaggtcc tccagcgcct gagttgcatg
      961 gccatcaagg gaaagatgtt cttggtggcc aatcttggga caaaacagcc ttgcctcggc
     1021 agcgaccctg ggtgcccgca ggacgggaga taccagttta acacaaacgt cgcgttcagt
     1081 gacaacggaa ccctcgtcgg ccgctaccgt aagcacaacc tgtactttga ggaagccttc
     1141 gatagccctg ctgacgtgga cctcaccacc tttgatacgc cgttcgcggg caagttcggt
     1201 atgttcactt gctttgatat cctgttcttt gaccccgcgg tccggctcct cagagacttt
     1261 gaggtaaagc acattgcgta ccctacggcc tggatgaacc agctgccgct cttggcagcc
     1321 attgaaatcc agaaagcatt cgccaccgcc ttcggcgtca ccgttctggc agctaacatc
     1381 caccacccga ctctggggat gacgggcagt ggcatacaca cccctctgaa gtccttttgg
     1441 taccataaca tggacgaccc cgaaggtcac cttataattg cccgggtagc cacaaaccca
     1501 cagggcctcg ttgggacaga gaatacaact agtgaaatgg atccgtccca taggaagttc
     1561 ttaaaagtct tgtctgggga tccgtactgt gagaaggatg cccaggaagt gcgctgcgac
     1621 gaggctgcca agtggaacct gaacgcacca cctaccttcc actcggagat gatgtatgac
     1681 aatttcaccc tggtccccgt ctggggaaag gaaggccacc tccaggtgtg ctccaacagt
     1741 ctctgttgcc acttactttt cgagaggccc gccctgtcca aagagctata tgccctgggt
     1801 gtctttgacg gactccacac agtgcacggt acctactacg ttcaagcctg tgccctggtc
     1861 aagtgcgggg gcgctggctt tgaaacctgc gggcaggaga tctcggaggc cgagggcttg
     1921 tttgactttc atctgtgggg gaacttcagc accttgtatg tcttcccttt atttctcacc
     1981 tcggggatga ccctagacac ccctgaccag ctcgggtggg agagcgacca ctatttcttg
     2041 aggaagaggg gactgtcctc cggcctggtg acggcagctc tctatgggcg gttgtatgag
     2101 aggaattagg aaaactgtgg tcagcaggtt gggctctgca ggctggcctt gccttcccac
     2161 ggcccacaga tcccaaacac tgggaaaacc gccccgcccc tgtggcactg gatcccaccc
     2221 tggggaactg taagaagatg ggagaggcag ttcctccttc ctttctacat aatgactgag
     2281 atattttctg gtattttcta ttcacattat tctttttcaa gccacaccct cttaccacta
     2341 ctacacaatt ggttttaaag actaagccaa aaaaaaaaaa aaaaaataaa catcagctgc
     2401 cattctacaa a
//
LOCUS       NM_001437074            6877 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            10, mRNA.
ACCESSION   NM_001437074 XM_063277627
VERSION     NM_001437074.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6877)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6877)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6877)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6877)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6877)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6877)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6877)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6877)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6877)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6877)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000018.1  65391441-65391665
            226-287             JAXUCZ010000018.1  65391770-65391831
            288-417             JAXUCZ010000018.1  65437939-65438068
            418-467             JAXUCZ010000018.1  65438528-65438577
            468-573             JAXUCZ010000018.1  65507173-65507278
            574-704             JAXUCZ010000018.1  65511025-65511155
            705-837             JAXUCZ010000018.1  65516916-65517048
            838-905             JAXUCZ010000018.1  65525175-65525242
            906-984             JAXUCZ010000018.1  65526319-65526397
            985-1061            JAXUCZ010000018.1  65528841-65528917
            1062-1265           JAXUCZ010000018.1  65531547-65531750
            1266-1401           JAXUCZ010000018.1  65551334-65551469
            1402-1552           JAXUCZ010000018.1  65553405-65553555
            1553-1782           JAXUCZ010000018.1  65556812-65557041
            1783-1923           JAXUCZ010000018.1  65557878-65558018
            1924-6877           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6877
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..225
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1919
                     /gene="Tcf4"
                     /note="isoform 10 is encoded by transcript variant 10;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 10"
                     /protein_id="NP_001424003.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MKDIFFQFLVARVRKRHSLSCLHTLPVVSPLRKTERGSYSSYGR
                     ENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKV
                     RKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSS
                     GMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNH
                     YSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTP
                     VGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVG
                     PSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGS
                     HSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDEN
                     LQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDI
                     NEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREE
                     EKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    324..>809
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    324..>809
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1587..1841
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1587..1841
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1611..1613,1623..1625,1629..1637,1641..1643,
                     1656..1658,1719..1724)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1611..1613,1623..1625,1629..1637,1641..1643,
                     1656..1658,1719..1724)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1650..1655,1662..1667,1671..1676,1683..1685,
                     1695..1697,1725..1727,1734..1736,1746..1748,1755..1757,
                     1764..1781)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1650..1655,1662..1667,1671..1676,1683..1685,
                     1695..1697,1725..1727,1734..1736,1746..1748,1755..1757,
                     1764..1781)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            226..287
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..417
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..467
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..573
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..704
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..837
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..905
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..984
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1061
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1265
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1401
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1552
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1782
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1923
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..6877
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaatggttc aaatttggtg agagaggaag aacgtgaaaa aaaaaggaat gacaatttgt
       61 ttgttagaga aagtggaggc cactggaatg acagtttttg gaagtgtgga gcagtttggc
      121 taagaatagg aatgaaagat atttttttcc agttccttgt cgccagagtg aggaagcgcc
      181 attccctgtc ttgcttgcat acattgccag ttgtgtctcc tctacgtaaa acagaaaggg
      241 gttcatactc atcttatggg agagaaaacg tacagggttg ccaccagcag agtctcctcg
      301 gaggggacat ggatatgggc aacccaggaa ccctttcgcc caccaaacct ggctcccagt
      361 actacccata ttccagcaat aacgcccgac ggaggcctct tcacagtagt accatggagg
      421 tgcagacaaa gaaagtcaga aaagttcctc caggcttgcc atcttcagtc tacgctcctt
      481 cagccagcac tgccgactac aacagggact caccaggcta ttcttcctcc aagccagcag
      541 ccagcacttt ctccagctcc ttcttcatgc aagatggcca tcacagcagt gacccttgga
      601 gctcctccag tggaatgaat cagcccggct atggagggat gctaggcaac tctcatatcc
      661 cacagtctag cagctactgt agcctgcatc cacatgaacg tctgagctat ccatcgcact
      721 cctcggcaga catcaactcc agtcttcctc cgatgtccac gttccatcga agtggcacaa
      781 accattacag cacctcttcc tgcacacctc ctgccaacgg aacagacagt ataatggcaa
      841 acagaggaac tggggcagca ggcagctccc agactggaga cgctctgggg aaagccctgg
      901 cttcgatcta ttctcctgat cacacgaaca acagcttctc ctccaaccct tcaactcctg
      961 ttggctcccc tccttcactc tcagcaggca cagctgtttg gtctcgaaac ggaggacagg
     1021 cctcgtcatc tcccaattac gaaggaccct tgcactcctt gcagagccga attgaagacc
     1081 gtttagaaag actggacgac gcgattcatg ttctccggaa ccacgcggtg ggcccatcca
     1141 cagctgtgcc cggtggccat ggggacatgc atgggatcat cggaccctct cacaatggag
     1201 caatgggcag tctgggctca ggatatggaa ctggccttct ctcagccaac agacattcac
     1261 tcatggtcgg ggcccaccgt gaagatggcg tggcactgag aggcagccat tctctcctgc
     1321 caaaccaggt tccggttcca cagcttccag tccagtctgc aacttcccct gacttgaacc
     1381 caccccaaga cccttacaga gggatgccac caggcctcca gggacagagt gtgtcttccg
     1441 gcagctctga gatcaagtcc gacgacgagg gcgatgagaa cctacaggac acaaaatctt
     1501 ccgaggacaa gaaactagac gacgacaaga aggatatcaa atcaattact agcaataacg
     1561 atgatgagga cctgaccccg gagcagaagg ccgagcgtga gaaggagcgg aggatggcca
     1621 ataacgcccg tgagcgcctg agggtccgtg atatcaacga ggctttcaag gagctgggcc
     1681 gcatggtaca gctccacctg aagagcgaca agccccagac caagctcctg attctccacc
     1741 aggcagtggc tgtcatcctc agcctggagc agcaagtgcg agaaaggaac ctgaacccaa
     1801 aagctgcctg tctgaaaaga agggaggaag agaaggtgtc ctcagagcct cccccgctct
     1861 ccttggctgg cccacaccct gggatgggag acgcagcgaa tcacatgggt cagatgtgaa
     1921 agggtccaag ttgccacctt gcttcattaa aacaagagac cacttcctta acagctgtat
     1981 tatcctaaac ccacataaac actgctcctt aaccccgttt tttttgtaat ataagacaag
     2041 tctgagtagt tatgaatcgc agacgcaaga ggtttcagca ttcccaatta tcaaaaaaca
     2101 gaaaaacaaa cacaaaaaaa aaatgaatga aagaaagaaa gaaagagaaa atgcaacttg
     2161 agggacgact tctttaacat atcactctga atgtgcgaag cggtatgtac aggctgagac
     2221 gcagcccaga gactgaatgg caatccttcc acactgtgga gcaatgcatt tgtgcctaaa
     2281 cttcttttgg aaaaaaaaat ataattaatt tgtaagtctg aaaaaaaata tttaatttaa
     2341 aaaaaattgt aaacttgcaa taatgaaaaa gtgtacttct gaagaaaaac gacatgaacg
     2401 tttttgttgg tattcaagtc agctagtgtt tctaattacc ggatattgaa tagaggaagc
     2461 ccggctaccc tcataacaaa accagcaacc gtcctgatgg caaccgaaat gatgacatta
     2521 gccattcctt agggtaggag ggacagatgg atgttataga cctatgacaa atatatatat
     2581 aaatatatat ataaatatat attaaaaatt tagtgactat ggtaagcttt tgttcatttg
     2641 tttcagactt ttttctcctg taaaaaaata gtactgatta acttttttaa aagaaagatt
     2701 ttactgtaaa tatggatttt tttttgtctg atttttgtcc cttcccccag tttgttatcg
     2761 tgacctgtag tgccaactct gcttccggag gggcagtgca ggacgaaatg ctgaccctga
     2821 tgttgcttct cattcataaa tagtagaaag ttgtttctcc agtcttttgg gaacacagga
     2881 cttaaaagtc acatcatgtg tagaaattac atgcagcatt gcccgggcaa ggcaaaaaga
     2941 gtttgtctgg cttgtggcac tgtgcttgtt accctctcct gggattttca gaggtacacg
     3001 gttagaatgc tacaatgtta ccactgtgcc ttccaatgtt tatatcatcg gaaacatgac
     3061 ataatcaaag tggctgtgat ttaacaaaaa aaaaaaaaga ttcaagtgtt acctacctgt
     3121 gtagcggaag tagtgtgcag tgagacgttt ctgaatacat ggtcagattt tttttggaaa
     3181 aaatacaaaa acaaaaaaaa aaaacaaaaa aatttaaaaa aaaaagtcaa gttcaaaaac
     3241 cgtcaaatga gaaaatcgca aggagtgtga cagctgattg attttgttgc ttttcttgat
     3301 tttttttttt ttgtttccaa atgggtttac taaaaagtac atgacttacc tgcctcctcc
     3361 ttcgtctgaa aacaaaaaac aaaaaaacaa tgccaaccta tcccacagca ttatagcaag
     3421 ccttataagc cctaaagcat taagttgcac tttggtgagg aggggtagcg cagtattctc
     3481 tctggccagt atgagtgaag tttatactta acatttgata gaaacataga tcaaactgtg
     3541 gcacagtaac tcatcagata gctagcgttg actctgggca caattgaacc aattcccatc
     3601 ctaaatcttt ccaacaattg actttggtgt acagtgcagt gaacacatag aactcctact
     3661 taagtattcg tcagcatcct tttgtctcta actcggttct gttttgacag ccacacaatc
     3721 ttggcatgta ttaagtaaaa aaaaaaaaaa aatccctgtt gaagtagttt tcccacctat
     3781 cagcactgag taattgccgt aactcaatgg aaatggtcta aacgcccccc atctcttgtc
     3841 ctgtaccacc agttacacag tgacaaaaca catctgtaaa ttttatgcaa ccaatggcaa
     3901 acctatcatt attttgaaac tgtgtatgta aaagttatat ttttacatgt agactcttgt
     3961 tattatgtgt tttaatacat tgtatcagtt ttttgtttcc tttttttttt aactgtgtgg
     4021 ttttaaaaag tcatttaaat gaaatagcga gctacaagaa tctgaaattt atgttcattt
     4081 ctgaaaatgt aagaacaaat aagatagtta tcacgtggtc accttttaca aacccatcga
     4141 tgttttgact agctgtgtgt atgtgtgtgt gtgcgcatgt gtgcgtgtgt gtgtatgtgt
     4201 gttgaaaact gtaaatatgt tcagtagcga taaaacgaca atgctttgat ttgttgagaa
     4261 gttcctaaaa tgtggaggtg gattgaaaat gtaggggaat agcagaaatc agatttcatg
     4321 aagagctctt ctcttcgggg gctttcctgt ggaatggtca aacagaggtg ctccaagaag
     4381 ggcaaggaag acagtaactt cccctcctcc ctgaacgacg gaaaccatgt gtacgtggtc
     4441 tctcaccatg ttaaagattt tctttccgtg atacattctg cactcttttt gtatagtcta
     4501 ccaaggcggg tatccctggg aacaatatta tgatatagga agcagtatac tctgatcaca
     4561 ttcaggagaa ttgtatagaa gagaatatgg tgtttactct ttagggaact ggaaattctc
     4621 cctgcattga tgtacatctt cagagcggcc cttttgatac acgttatcat aaaggtgctg
     4681 actaaagcag aattaaagtt tttcaaatct gtaaacaaag caaaaaatta aattacagtc
     4741 attcgattgt ttgttttttt ttttttccaa ttggtgcttt tatattttgt tctcactcag
     4801 acagaaaagg ctgcaatttc ttgttcacca gctttgatgt attcattact cggtaatgta
     4861 atacggctat tgtcaaattc cttttggaaa taagcaaaag gcttccccaa ggcctgcagc
     4921 agctgctggc tactttctgc ttggcgcaga aacatgatct gaccctctct gtagtaatcg
     4981 agttgtatct ccagttttaa aaagaaggaa aaagggaatg tggccgtttt aatgtgtttt
     5041 tttttttctt ttcttgttgt tattttgtaa ttctcaaacc caggtaagat attggtattc
     5101 ctgcactgga tttttgaaag aaacttagca gaagacagga tcgagatact atagaagcat
     5161 ttcccaagtg ttcatactat actagacata aatgataacg gcgatgtata ggttcaggat
     5221 cggtttaaga gactcagact ttgaaagcaa cttggaacgg ttgatccacc tccacattcg
     5281 agtaattaat aattctgcag aattagggat ctgtccatct aggagttgtt acccatttgt
     5341 cttctgtgtg gctgcgagga acactaacgc ttttacaact gtcagttcac ccagtggtac
     5401 aactgattct gactcagtct tccgattcct gttttgtatt ttgtttttcc acttttttcc
     5461 tatctcttga ttttattgtt gttgttattg ctattgttat tattattatt cgtgatcttt
     5521 atttcgatga ggggttggga agtgggaggg agtcgaactg agactagggg ttgagaggat
     5581 ttttttggtt tggttttctt ttcttttttt tttgtttttt tttttttttg tttgtttgtt
     5641 tcatctttgc gtccaacagg cagaatatgg tctgtgtcca aaacggaact taagtcagga
     5701 aggaaaccat tcagcgtaaa caagcacaac atgtagtctg tcggctgtct ggaagcaaaa
     5761 ataaattaat aaataaataa taaataagta aaagacacac acggaggtga agatgaaatg
     5821 tgatggattc cgagacaatg gggcaccaag gcctgtaggc ctcctcttga ttttgctttg
     5881 gttatgtttg ttttccttag agatgttttt ttcctcacgg gacttgaagt gactcatctc
     5941 tgtgcagtaa tggtttcgcc atatgctcat ttcaagtatt atagacatat gtaatggtga
     6001 aatatatgaa ctgtggcctt tttcattctt gttatttgtg atgcaattaa gtgaagagaa
     6061 gaaaaaaaaa agcagagatt taccatgtat cagtgcctgg ctttttgtta taaagcttcg
     6121 tctgtctagt gctctttttg ctataaaaat agactgtagt acaccctagt aggaaaaaaa
     6181 aaccctaaat ttaaaaataa aaaaatatat ttggcttatt tttcgcagga gcaatccttt
     6241 tataccatgg atattacaaa aaaaaaaatt gtcagattct gaatatttct tctttgtaga
     6301 tttttggaat cattataagt aaaagtttgt tactttattt tactatttaa aagatgttat
     6361 tttgccatgt gttactgaga tgaaactgta tggtatagct tcttctgttc gttttttgtt
     6421 tccggttttt tgtttgttcg tttttggttt tttttttttt tgtttgtttg ttttgttttg
     6481 tttttttttc ttagttgtag gtcgcagtaa ggacttttcc ttttgttttt gttttttcgt
     6541 tatgttttgt tttgtttttg cgactgtaca catagctgca gcattaaaaa cttttaaaaa
     6601 aatctgttaa aaaaaaaaga aaaaaaaggg aaaacgttta aaaaaaaaag ataaacagtt
     6661 acaccttgtt ttcaacgtgt ggctgagtgc ctcgattttt tcatgttttt ggtgtatttc
     6721 tgatttgtag aagtgtccaa acaggttgtg tcctggactt ccttcaagag gcgaacaacc
     6781 cagcttggtc taggccatga cctgttccca tctgtagtta ctcgatgaag tcatgtacat
     6841 gaccgttctg tagcaataaa tgtgccattt ttataaa
//
LOCUS       NM_001106000            1343 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor COX18
            (Cox18), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001106000 XM_001072704 XM_214011
VERSION     NM_001106000.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Bourens,M. and Barrientos,A.
  TITLE     Human mitochondrial cytochrome c oxidase assembly factor COX18 acts
            transiently as a membrane insertase within the subunit 2 maturation
            module
  JOURNAL   J Biol Chem 292 (19), 7774-7783 (2017)
   PUBMED   28330871
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Gaisne,M. and Bonnefoy,N.
  TITLE     The COX18 gene, involved in mitochondrial biogenesis, is
            functionally conserved and tightly regulated in humans and fission
            yeast
  JOURNAL   FEMS Yeast Res 6 (6), 869-882 (2006)
   PUBMED   16911509
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Sacconi,S., Trevisson,E., Pistollato,F., Baldoin,M.C.,
            Rezzonico,R., Bourget,I., Desnuelle,C., Tenconi,R., Basso,G.,
            DiMauro,S. and Salviati,L.
  TITLE     hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase
            assembly
  JOURNAL   Biochem Biophys Res Commun 337 (3), 832-839 (2005)
   PUBMED   16212937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001106000.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.364187.1,
                                           SRR26360186.2585082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000014.1  18149994-18150384
            392-492             JAXUCZ010000014.1  18151605-18151705
            493-656             JAXUCZ010000014.1  18155050-18155213
            657-778             JAXUCZ010000014.1  18155534-18155655
            779-886             JAXUCZ010000014.1  18158802-18158909
            887-1343            JAXUCZ010000014.1  18161166-18161622
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1343
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="cytochrome c oxidase assembly factor COX18"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
     exon            1..391
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="upstream in-frame stop codon"
     CDS             68..1063
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial inner membrane protein COX18; COX18
                     cytochrome c oxidase assembly homolog; cytochrome c
                     oxidase assembly homolog 18; cytochrome c oxidase assembly
                     protein 18; COX18, cytochrome c oxidase assembly factor"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein COX18
                     isoform 1"
                     /protein_id="NP_001099470.1"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
                     /translation="MLCGSCAGLLRSLRTLQLRAPGSLPAWSSARLPTLPVWAAASVS
                     AASPGGWYEALAASAPVHAAEEMLLSAQETTGLPWWGNILLSTVVLRGAVTLPLAAYQ
                     HYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNIRRLVSELYVRD
                     NCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDGISVQDQLAAGGTLWFPDLTAV
                     DSTWILPVSVGVVNLLIVEIFALQKIGKSRFQMYVTNFVRAVSVLMVPVAATVPSALV
                     LYWLCSSLMGLSQNLLLRSPGFRQLCRIPPSRSDSETPYRDLSAAFCAKFLSRKR"
     misc_feature    293..955
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="Five transmembrane core domain of mitochondrial
                     inner membrane protein Oxa1 and similar proteins; Region:
                     5TM_Oxa1-like; cd20069"
                     /db_xref="CDD:410993"
     misc_feature    293..955
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="Five transmembrane core domain of mitochondrial
                     inner membrane protein Oxa1 and similar proteins; Region:
                     5TM_Oxa1-like; cd20069"
                     /db_xref="CDD:410993"
     exon            392..492
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            493..656
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            657..778
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            779..886
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1343
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagcctc ctgatggcca aggtctaggt gtcttcctcg ctgacctgcc gcccgtcgtg
       61 tctagccatg ctatgcggat cgtgtgccgg gttgctccgg tcgctgcgca ccttgcagct
      121 ccgggcaccg ggatcactgc ccgcctggag cagcgcgcgg ctcccaaccc ttccggtatg
      181 ggcggccgcg tcggtttcgg cggcctctcc gggtggctgg tatgaggccc tggcagcgtc
      241 ggcgcccgtg catgcggcgg aggaaatgct gctgagcgcg caggagacca caggcctccc
      301 ttggtggggt aacatcttac tcagcaccgt tgtcctgcgt ggtgctgtca ctctgcccct
      361 ggccgcctat caacattaca tccttgctaa ggtggaaaac ttgcaaccag aaataaaaga
      421 catcgccaag cgccttaacc aagaagttgc agtctgtgca cgtcagtttg gttggtccaa
      481 gagagtggcc agactcactt acctgaagaa cattcgcaga cttgtgtcgg agctgtacgt
      541 tcgtgacaac tgccatcctt tcaaagccac ggtcctagtc tgggtccagc ttccaatgtg
      601 ggtcttcata tccgtcgccc tccggaacct tagcacaggg gccacacatt cagacggcat
      661 ttctgttcag gaccagttag ctgccggcgg gaccctgtgg tttcctgacc tcactgcagt
      721 ggattccacc tggattctgc ctgtctctgt tggtgttgtc aacttactga tagtggagat
      781 ttttgctctt caaaaaatcg ggaagtcacg ttttcaaatg tatgttacga attttgttcg
      841 agccgtctcg gtgttgatgg tcccagtggc tgccacagta ccctcggcgc ttgttctcta
      901 ctggctgtgc tccagcctca tgggcctctc tcagaacctt ctgctgcgct cccctggctt
      961 ccgacagctg tgccggatac caccaagcag gtcagactcg gagaccccgt acagagacct
     1021 ctctgctgcc ttttgcgcca agttcctttc aagaaaacga tgagttcgct cccagttccg
     1081 tgaaaaaatt acagatgtca ctgtcagctt catgcactga attttgaagc ttttatttaa
     1141 atatcatgaa gcacagtggg aaagatgtaa tttggatgta tttgacattt agtattaaaa
     1201 actaaatgtt cagttgtaag agtgtaaaaa taagacagga tgcctggcct tgttcataaa
     1261 aatcatagtt ttgctgagaa caggattaga tcctgtgtaa tctctgtgcc caactgtcca
     1321 caaataaagg tttataaatt aaa
//
LOCUS       NM_001437027            2392 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 13, mRNA.
ACCESSION   NM_001437027 XM_006252614
VERSION     NM_001437027.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2392)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2392)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2392)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2392)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252614.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2071364.1,
                                           SRR26643297.46336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-508             JAXUCZ010000016.1  6893598-6893959
            509-767             JAXUCZ010000016.1  6894275-6894533
            768-917             JAXUCZ010000016.1  6898222-6898371
            918-2392            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2392
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..508
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    402..404
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            509..767
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..2090
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 13; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423956.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     525..599
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     600..2087
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    630..1541
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    630..1541
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(792..794,1092..1094,1104..1106,1110..1112,
                     1191..1196,1200..1205,1269..1271)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(792..794,1092..1094,1104..1106,1110..1112,
                     1191..1196,1200..1205,1269..1271)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(792..794,1092..1094,1191..1193)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(792..794,1092..1094,1191..1193)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    906..908
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    1065..1067
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(1095..1109,1128..1136,1194..1196,1200..1214,
                     1221..1226,1287..1292,1296..1304,1308..1313,1383..1388,
                     1527..1541)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(1095..1109,1128..1136,1194..1196,1200..1214,
                     1221..1226,1287..1292,1296..1304,1308..1313,1383..1388,
                     1527..1541)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1635..2084
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1635..2084
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1662..1664
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            768..917
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            918..2392
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaaaa tcccatgtta ccactatgag aaggattttc
      181 tttccaaagc ggtacgtcct taagcaagtg attcggagta gcagacaaag cagaaaacag
      241 tgaaagccgt gtgcgggact ctgacaggga gacttcttta tggctgccct gtgggtgaca
      301 cagcagatgc tagaattcca aaccgcccca aataaaaact gaagaatatc ggctaggaag
      361 ctgccctgcg ttcgggagcc tcaggaccat cgcggctgtc ctagagggct gacctgcaat
      421 gctatgtatg taagaagact cgagcaaagc atcatcaaat atatcgcaga attgtgtcca
      481 aatttcagcc cagttcctgc ggcgcaggat ttacggtctg cattatgtct ggagcccgca
      541 ctgcgcatgc gctcgtcttc ctcctcggct gttctgcgct tgcgttgggc gtctgctcag
      601 cctccctgga gcacggcgag gctgagtact acgtggctgc cgtgtacgaa caccgatcgg
      661 tcctgagccc aaaccccctg gagctcagca gccgccagca ggccctggag ctcatgaagc
      721 agaacctcga cgtctatgaa cagcaagtga tggctgcagc ccagaagggt gcgcacatta
      781 tagtgttccc agaagacggt atccacggat tcaacttcac aagaacatcc atttacccat
      841 tcttggactt gatgccatct cccaggctgg tcagttggaa cccgtgtctg gagccctttc
      901 gcttcaatga cacggaggtc ctccagcgcc tgagttgcat ggccatcaag ggaaagatgt
      961 tcttggtggc caatcttggg acaaaacagc cttgcctcgg cagcgaccct gggtgcccgc
     1021 aggacgggag ataccagttt aacacaaacg tcgcgttcag tgacaacgga accctcgtcg
     1081 gccgctaccg taagcacaac ctgtactttg aggaagcctt cgatagccct gctgacgtgg
     1141 acctcaccac ctttgatacg ccgttcgcgg gcaagttcgg tatgttcact tgctttgata
     1201 tcctgttctt tgaccccgcg gtccggctcc tcagagactt tgaggtaaag cacattgcgt
     1261 accctacggc ctggatgaac cagctgccgc tcttggcagc cattgaaatc cagaaagcat
     1321 tcgccaccgc cttcggcgtc accgttctgg cagctaacat ccaccacccg actctgggga
     1381 tgacgggcag tggcatacac acccctctga agtccttttg gtaccataac atggacgacc
     1441 ccgaaggtca ccttataatt gcccgggtag ccacaaaccc acagggcctc gttgggacag
     1501 agaatacaac tagtgaaatg gatccgtccc ataggaagtt cttaaaagtc ttgtctgggg
     1561 atccgtactg tgagaaggat gcccaggaag tgcgctgcga cgaggctgcc aagtggaacc
     1621 tgaacgcacc acctaccttc cactcggaga tgatgtatga caatttcacc ctggtccccg
     1681 tctggggaaa ggaaggccac ctccaggtgt gctccaacag tctctgttgc cacttacttt
     1741 tcgagaggcc cgccctgtcc aaagagctat atgccctggg tgtctttgac ggactccaca
     1801 cagtgcacgg tacctactac gttcaagcct gtgccctggt caagtgcggg ggcgctggct
     1861 ttgaaacctg cgggcaggag atctcggagg ccgagggctt gtttgacttt catctgtggg
     1921 ggaacttcag caccttgtat gtcttccctt tatttctcac ctcggggatg accctagaca
     1981 cccctgacca gctcgggtgg gagagcgacc actatttctt gaggaagagg ggactgtcct
     2041 ccggcctggt gacggcagct ctctatgggc ggttgtatga gaggaattag gaaaactgtg
     2101 gtcagcaggt tgggctctgc aggctggcct tgccttccca cggcccacag atcccaaaca
     2161 ctgggaaaac cgccccgccc ctgtggcact ggatcccacc ctggggaact gtaagaagat
     2221 gggagaggca gttcctcctt cctttctaca taatgactga gatattttct ggtattttct
     2281 attcacatta ttctttttca agccacaccc tcttaccact actacacaat tggttttaaa
     2341 gactaagcca aaaaaaaaaa aaaaaaataa acatcagctg ccattctaca aa
//
LOCUS       NM_001437079            6969 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            12, mRNA.
ACCESSION   NM_001437079 XM_063277629
VERSION     NM_001437079.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6969)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6969)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6969)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6969)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6969)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6969)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6969)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6969)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6969)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6969)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277629.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1917391.1,
                                           SRR26360194.1990626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000018.1  65393471-65393849
            380-509             JAXUCZ010000018.1  65437939-65438068
            510-559             JAXUCZ010000018.1  65438528-65438577
            560-665             JAXUCZ010000018.1  65507173-65507278
            666-796             JAXUCZ010000018.1  65511025-65511155
            797-929             JAXUCZ010000018.1  65516916-65517048
            930-997             JAXUCZ010000018.1  65525175-65525242
            998-1076            JAXUCZ010000018.1  65526319-65526397
            1077-1153           JAXUCZ010000018.1  65528841-65528917
            1154-1357           JAXUCZ010000018.1  65531547-65531750
            1358-1493           JAXUCZ010000018.1  65551334-65551469
            1494-1644           JAXUCZ010000018.1  65553405-65553555
            1645-1874           JAXUCZ010000018.1  65556812-65557041
            1875-2015           JAXUCZ010000018.1  65557878-65558018
            2016-6969           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6969
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..379
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    176..178
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            380..509
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..2011
                     /gene="Tcf4"
                     /note="isoform 12 is encoded by transcript variant 12;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 12"
                     /protein_id="NP_001424008.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVR
                     KVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSG
                     MNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHY
                     STSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPV
                     GSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGP
                     STAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSH
                     SLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENL
                     QDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDIN
                     EAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEE
                     KVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    416..>901
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    416..>901
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1679..1933
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1679..1933
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1703..1705,1715..1717,1721..1729,1733..1735,
                     1748..1750,1811..1816)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1703..1705,1715..1717,1721..1729,1733..1735,
                     1748..1750,1811..1816)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1742..1747,1754..1759,1763..1768,1775..1777,
                     1787..1789,1817..1819,1826..1828,1838..1840,1847..1849,
                     1856..1873)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1742..1747,1754..1759,1763..1768,1775..1777,
                     1787..1789,1817..1819,1826..1828,1838..1840,1847..1849,
                     1856..1873)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            510..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            560..665
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..796
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            797..929
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            930..997
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1076
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1153
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1357
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1493
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1644
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1874
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2015
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..6969
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagaaga aagttaacaa catccttcct ctttgcagat ggtcatggca caggtctcta
       61 tttttcgctg ggcccctttt gctggtcatc gagagagtag gcttcctaga ccctgcatcc
      121 tttcttgcta acagaaattg gcataattcc tcacagacac agagatttcc tctgctgagt
      181 aagcctgagg cccctgaact tgggaaagca tcatccagac cgtgggagtc agtgtgtgta
      241 cagagcgcag tcccttctcc ctccgtgttt ttgtttttgt tttttttggg ggggggttgt
      301 ttgtttgttt gtttgggttt tttttttcca ggggaatact tccttcggtg aaactgaact
      361 tttttttttc aagcacaagc agagtctcct cggaggggac atggatatgg gcaacccagg
      421 aaccctttcg cccaccaaac ctggctccca gtactaccca tattccagca ataacgcccg
      481 acggaggcct cttcacagta gtaccatgga ggtgcagaca aagaaagtca gaaaagttcc
      541 tccaggcttg ccatcttcag tctacgctcc ttcagccagc actgccgact acaacaggga
      601 ctcaccaggc tattcttcct ccaagccagc agccagcact ttctccagct ccttcttcat
      661 gcaagatggc catcacagca gtgacccttg gagctcctcc agtggaatga atcagcccgg
      721 ctatggaggg atgctaggca actctcatat cccacagtct agcagctact gtagcctgca
      781 tccacatgaa cgtctgagct atccatcgca ctcctcggca gacatcaact ccagtcttcc
      841 tccgatgtcc acgttccatc gaagtggcac aaaccattac agcacctctt cctgcacacc
      901 tcctgccaac ggaacagaca gtataatggc aaacagagga actggggcag caggcagctc
      961 ccagactgga gacgctctgg ggaaagccct ggcttcgatc tattctcctg atcacacgaa
     1021 caacagcttc tcctccaacc cttcaactcc tgttggctcc cctccttcac tctcagcagg
     1081 cacagctgtt tggtctcgaa acggaggaca ggcctcgtca tctcccaatt acgaaggacc
     1141 cttgcactcc ttgcagagcc gaattgaaga ccgtttagaa agactggacg acgcgattca
     1201 tgttctccgg aaccacgcgg tgggcccatc cacagctgtg cccggtggcc atggggacat
     1261 gcatgggatc atcggaccct ctcacaatgg agcaatgggc agtctgggct caggatatgg
     1321 aactggcctt ctctcagcca acagacattc actcatggtc ggggcccacc gtgaagatgg
     1381 cgtggcactg agaggcagcc attctctcct gccaaaccag gttccggttc cacagcttcc
     1441 agtccagtct gcaacttccc ctgacttgaa cccaccccaa gacccttaca gagggatgcc
     1501 accaggcctc cagggacaga gtgtgtcttc cggcagctct gagatcaagt ccgacgacga
     1561 gggcgatgag aacctacagg acacaaaatc ttccgaggac aagaaactag acgacgacaa
     1621 gaaggatatc aaatcaatta ctagcaataa cgatgatgag gacctgaccc cggagcagaa
     1681 ggccgagcgt gagaaggagc ggaggatggc caataacgcc cgtgagcgcc tgagggtccg
     1741 tgatatcaac gaggctttca aggagctggg ccgcatggta cagctccacc tgaagagcga
     1801 caagccccag accaagctcc tgattctcca ccaggcagtg gctgtcatcc tcagcctgga
     1861 gcagcaagtg cgagaaagga acctgaaccc aaaagctgcc tgtctgaaaa gaagggagga
     1921 agagaaggtg tcctcagagc ctcccccgct ctccttggct ggcccacacc ctgggatggg
     1981 agacgcagcg aatcacatgg gtcagatgtg aaagggtcca agttgccacc ttgcttcatt
     2041 aaaacaagag accacttcct taacagctgt attatcctaa acccacataa acactgctcc
     2101 ttaaccccgt tttttttgta atataagaca agtctgagta gttatgaatc gcagacgcaa
     2161 gaggtttcag cattcccaat tatcaaaaaa cagaaaaaca aacacaaaaa aaaaatgaat
     2221 gaaagaaaga aagaaagaga aaatgcaact tgagggacga cttctttaac atatcactct
     2281 gaatgtgcga agcggtatgt acaggctgag acgcagccca gagactgaat ggcaatcctt
     2341 ccacactgtg gagcaatgca tttgtgccta aacttctttt ggaaaaaaaa atataattaa
     2401 tttgtaagtc tgaaaaaaaa tatttaattt aaaaaaaatt gtaaacttgc aataatgaaa
     2461 aagtgtactt ctgaagaaaa acgacatgaa cgtttttgtt ggtattcaag tcagctagtg
     2521 tttctaatta ccggatattg aatagaggaa gcccggctac cctcataaca aaaccagcaa
     2581 ccgtcctgat ggcaaccgaa atgatgacat tagccattcc ttagggtagg agggacagat
     2641 ggatgttata gacctatgac aaatatatat ataaatatat atataaatat atattaaaaa
     2701 tttagtgact atggtaagct tttgttcatt tgtttcagac ttttttctcc tgtaaaaaaa
     2761 tagtactgat taactttttt aaaagaaaga ttttactgta aatatggatt tttttttgtc
     2821 tgatttttgt cccttccccc agtttgttat cgtgacctgt agtgccaact ctgcttccgg
     2881 aggggcagtg caggacgaaa tgctgaccct gatgttgctt ctcattcata aatagtagaa
     2941 agttgtttct ccagtctttt gggaacacag gacttaaaag tcacatcatg tgtagaaatt
     3001 acatgcagca ttgcccgggc aaggcaaaaa gagtttgtct ggcttgtggc actgtgcttg
     3061 ttaccctctc ctgggatttt cagaggtaca cggttagaat gctacaatgt taccactgtg
     3121 ccttccaatg tttatatcat cggaaacatg acataatcaa agtggctgtg atttaacaaa
     3181 aaaaaaaaaa gattcaagtg ttacctacct gtgtagcgga agtagtgtgc agtgagacgt
     3241 ttctgaatac atggtcagat tttttttgga aaaaatacaa aaacaaaaaa aaaaaacaaa
     3301 aaaatttaaa aaaaaaagtc aagttcaaaa accgtcaaat gagaaaatcg caaggagtgt
     3361 gacagctgat tgattttgtt gcttttcttg attttttttt ttttgtttcc aaatgggttt
     3421 actaaaaagt acatgactta cctgcctcct ccttcgtctg aaaacaaaaa acaaaaaaac
     3481 aatgccaacc tatcccacag cattatagca agccttataa gccctaaagc attaagttgc
     3541 actttggtga ggaggggtag cgcagtattc tctctggcca gtatgagtga agtttatact
     3601 taacatttga tagaaacata gatcaaactg tggcacagta actcatcaga tagctagcgt
     3661 tgactctggg cacaattgaa ccaattccca tcctaaatct ttccaacaat tgactttggt
     3721 gtacagtgca gtgaacacat agaactccta cttaagtatt cgtcagcatc cttttgtctc
     3781 taactcggtt ctgttttgac agccacacaa tcttggcatg tattaagtaa aaaaaaaaaa
     3841 aaaatccctg ttgaagtagt tttcccacct atcagcactg agtaattgcc gtaactcaat
     3901 ggaaatggtc taaacgcccc ccatctcttg tcctgtacca ccagttacac agtgacaaaa
     3961 cacatctgta aattttatgc aaccaatggc aaacctatca ttattttgaa actgtgtatg
     4021 taaaagttat atttttacat gtagactctt gttattatgt gttttaatac attgtatcag
     4081 ttttttgttt cctttttttt ttaactgtgt ggttttaaaa agtcatttaa atgaaatagc
     4141 gagctacaag aatctgaaat ttatgttcat ttctgaaaat gtaagaacaa ataagatagt
     4201 tatcacgtgg tcacctttta caaacccatc gatgttttga ctagctgtgt gtatgtgtgt
     4261 gtgtgcgcat gtgtgcgtgt gtgtgtatgt gtgttgaaaa ctgtaaatat gttcagtagc
     4321 gataaaacga caatgctttg atttgttgag aagttcctaa aatgtggagg tggattgaaa
     4381 atgtagggga atagcagaaa tcagatttca tgaagagctc ttctcttcgg gggctttcct
     4441 gtggaatggt caaacagagg tgctccaaga agggcaagga agacagtaac ttcccctcct
     4501 ccctgaacga cggaaaccat gtgtacgtgg tctctcacca tgttaaagat tttctttccg
     4561 tgatacattc tgcactcttt ttgtatagtc taccaaggcg ggtatccctg ggaacaatat
     4621 tatgatatag gaagcagtat actctgatca cattcaggag aattgtatag aagagaatat
     4681 ggtgtttact ctttagggaa ctggaaattc tccctgcatt gatgtacatc ttcagagcgg
     4741 cccttttgat acacgttatc ataaaggtgc tgactaaagc agaattaaag tttttcaaat
     4801 ctgtaaacaa agcaaaaaat taaattacag tcattcgatt gtttgttttt ttttttttcc
     4861 aattggtgct tttatatttt gttctcactc agacagaaaa ggctgcaatt tcttgttcac
     4921 cagctttgat gtattcatta ctcggtaatg taatacggct attgtcaaat tccttttgga
     4981 aataagcaaa aggcttcccc aaggcctgca gcagctgctg gctactttct gcttggcgca
     5041 gaaacatgat ctgaccctct ctgtagtaat cgagttgtat ctccagtttt aaaaagaagg
     5101 aaaaagggaa tgtggccgtt ttaatgtgtt tttttttttc ttttcttgtt gttattttgt
     5161 aattctcaaa cccaggtaag atattggtat tcctgcactg gatttttgaa agaaacttag
     5221 cagaagacag gatcgagata ctatagaagc atttcccaag tgttcatact atactagaca
     5281 taaatgataa cggcgatgta taggttcagg atcggtttaa gagactcaga ctttgaaagc
     5341 aacttggaac ggttgatcca cctccacatt cgagtaatta ataattctgc agaattaggg
     5401 atctgtccat ctaggagttg ttacccattt gtcttctgtg tggctgcgag gaacactaac
     5461 gcttttacaa ctgtcagttc acccagtggt acaactgatt ctgactcagt cttccgattc
     5521 ctgttttgta ttttgttttt ccactttttt cctatctctt gattttattg ttgttgttat
     5581 tgctattgtt attattatta ttcgtgatct ttatttcgat gaggggttgg gaagtgggag
     5641 ggagtcgaac tgagactagg ggttgagagg atttttttgg tttggttttc ttttcttttt
     5701 tttttgtttt tttttttttt tgtttgtttg tttcatcttt gcgtccaaca ggcagaatat
     5761 ggtctgtgtc caaaacggaa cttaagtcag gaaggaaacc attcagcgta aacaagcaca
     5821 acatgtagtc tgtcggctgt ctggaagcaa aaataaatta ataaataaat aataaataag
     5881 taaaagacac acacggaggt gaagatgaaa tgtgatggat tccgagacaa tggggcacca
     5941 aggcctgtag gcctcctctt gattttgctt tggttatgtt tgttttcctt agagatgttt
     6001 ttttcctcac gggacttgaa gtgactcatc tctgtgcagt aatggtttcg ccatatgctc
     6061 atttcaagta ttatagacat atgtaatggt gaaatatatg aactgtggcc tttttcattc
     6121 ttgttatttg tgatgcaatt aagtgaagag aagaaaaaaa aaagcagaga tttaccatgt
     6181 atcagtgcct ggctttttgt tataaagctt cgtctgtcta gtgctctttt tgctataaaa
     6241 atagactgta gtacacccta gtaggaaaaa aaaaccctaa atttaaaaat aaaaaaatat
     6301 atttggctta tttttcgcag gagcaatcct tttataccat ggatattaca aaaaaaaaaa
     6361 ttgtcagatt ctgaatattt cttctttgta gatttttgga atcattataa gtaaaagttt
     6421 gttactttat tttactattt aaaagatgtt attttgccat gtgttactga gatgaaactg
     6481 tatggtatag cttcttctgt tcgttttttg tttccggttt tttgtttgtt cgtttttggt
     6541 tttttttttt tttgtttgtt tgttttgttt tgtttttttt tcttagttgt aggtcgcagt
     6601 aaggactttt ccttttgttt ttgttttttc gttatgtttt gttttgtttt tgcgactgta
     6661 cacatagctg cagcattaaa aacttttaaa aaaatctgtt aaaaaaaaaa gaaaaaaaag
     6721 ggaaaacgtt taaaaaaaaa agataaacag ttacaccttg ttttcaacgt gtggctgagt
     6781 gcctcgattt tttcatgttt ttggtgtatt tctgatttgt agaagtgtcc aaacaggttg
     6841 tgtcctggac ttccttcaag aggcgaacaa cccagcttgg tctaggccat gacctgttcc
     6901 catctgtagt tactcgatga agtcatgtac atgaccgttc tgtagcaata aatgtgccat
     6961 ttttataaa
//
LOCUS       NM_001437073            5336 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437073 XM_006239029
VERSION     NM_001437073.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5336)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5336)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5336)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5336)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5336)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5336)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5336)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5336)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5336)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006239029.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.493683.1,
                                           SRR26360186.2800755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1482           JAXUCZ010000005.1  148197665-148197781
            1483-1634           JAXUCZ010000005.1  148200975-148201126
            1635-1773           JAXUCZ010000005.1  148203568-148203706
            1774-1917           JAXUCZ010000005.1  148205552-148205695
            1918-2214           JAXUCZ010000005.1  148206678-148206974
            2215-2451           JAXUCZ010000005.1  148208059-148208295
            2452-2719           JAXUCZ010000005.1  148218465-148218732
            2720-2849           JAXUCZ010000005.1  148219783-148219912
            2850-2984           JAXUCZ010000005.1  148221617-148221751
            2985-3122           JAXUCZ010000005.1  148225153-148225290
            3123-3248           JAXUCZ010000005.1  148228732-148228857
            3249-3370           JAXUCZ010000005.1  148229514-148229635
            3371-3563           JAXUCZ010000005.1  148231206-148231398
            3564-5336           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5336
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3695
                     /gene="Pum1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 2"
                     /protein_id="NP_001424002.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGMFPAGLAPAAFVPNPYIISAAPPGTDPYTAGL
                     AAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQV
                     LRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQ
                     TGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGP
                     FRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGS
                     SSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSL
                     SFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEA
                     KYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAG
                     HIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFG
                     SHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGHVLKCV
                     KDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTL
                     PILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNV
                     VEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKI
                     VMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2655..3626
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2655..3626
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2823..2828,2835..2837,2931..2936,2943..2945,
                     3048..3050,3057..3059,3153..3158,3165..3167,3252..3257,
                     3261..3266,3273..3275,3360..3365,3369..3374,3381..3383,
                     3489..3494,3498..3503,3510..3512,3600..3602,3609..3611)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2823..2828,2835..2837,2931..2936,2943..2945,
                     3048..3050,3057..3059,3153..3158,3165..3167,3252..3257,
                     3261..3266,3273..3275,3360..3365,3369..3374,3381..3383,
                     3489..3494,3498..3503,3510..3512,3600..3602,3609..3611)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1482
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1634
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1773
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1917
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2214
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2451
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2719
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2849
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2984
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3122
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3248
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3370
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3563
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..5336
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggtatg tttccagcag
     1381 gtttagctcc cgctgcgttt gtccccaacc catacatcat cagcgctgct cccccaggga
     1441 cggaccccta cacagctgga ttggctgcag cagcgacact cggcccagct gtggtccctc
     1501 accaatatta tggagtcacg ccatggggtg tctatcctgc tagtcttttc cagcaacaag
     1561 ctgctgcagc tgcagcagca acaaattcag ctactcagca gagtgcccca caggcccagc
     1621 agggacagca gcaggttctt cgtggaggag ctagccagcg tcctttgacc ccaaatcaga
     1681 accagcaggg acaacaaaca gatccccttg tagcagctgc agcagtgaac tctgctcttg
     1741 cctttggaca aggattggct gcaggtatgc caggttatcc agtcttggca cctgctgctt
     1801 actatgacca aactggtgcc cttgtggtga atgcaggggc aagaaatggc ctcggagctc
     1861 cagttcggct tgttgctcca gccccagtca tcattagctc ctcagctgca caagcagctg
     1921 ttgcagcggc tgcagcttca gcaaatggag cagccggtgg tcttgcagga actacaaatg
     1981 gaccatttcg acctttaggc acccagcagc cccagcccca gccccagcag cagcccagta
     2041 acaatctggc ttccagctct ttctatggca acaactctct gagcagtaac tcccagagca
     2101 gctccctctt ctctcagggc tccgcccagc ctgccaacac gtccttggga ttcggaagca
     2161 gcagttccct tggtgccacc ctaggatcgg cccttggagg gtttggaaca gcagttgcaa
     2221 actccaacac tggcagtggc tcccgccgtg actccctgac tggcagcagt gacctttata
     2281 agaggacatc gagcagcttg gcccccattg gacacagttt ttataacagc cttagctttt
     2341 cctcctctcc tggacccgtg ggcatgcctc tccctagtca gggaccagga cattcacaga
     2401 caccacctcc ttccctctct tcacatggat cctcttcaag cttaaacctg ggaggactca
     2461 cgaacggcag tggaagatac atctctgctg ctcctggtgc cgaagccaag taccgcagtg
     2521 cgagcagtgc ctccagcctt ttcagcccca gcagcaccct tttttcttcc tctcgtttga
     2581 gatacggaat gtctgatgtt atgccctctg gcaggagcag acttctggaa gactttcgaa
     2641 acaaccggta ccctaattta caactgcggg agattgccgg gcatataatg gaattttccc
     2701 aagaccagca tggttctaga ttcattcagc tgaaactaga gcgagccaca gcagctgagc
     2761 gccagcttgt cttcaacgaa atcctgcagg ctgcgtacca acttatggtg gatgtgtttg
     2821 gaaattacgt cattcagaag ttctttgaat ttggcagcca tgaacagaag ctggctttgg
     2881 ctgaacggat tcgaggccac gtcctatcat tggcactgca gatgtatggc tgccgagtca
     2941 tccagaaagc tttggaattt attccctcag accagcaggt aattaacgag atggtgcggg
     3001 agctagatgg ccatgtcctg aagtgtgtga aagaccagaa tggcaaccat gtggttcaga
     3061 agtgcattga atgtgtacag ccccagtctt tgcagttcat catcgatgca ttcaaggggc
     3121 aggtgtttgc tttgtctacg cacccatatg gctgtagggt gatccagagg atcctggaac
     3181 actgtctccc cgaccagacc ctccctatcc tggaggagct tcaccagcac acggagcagc
     3241 tcgtgcagga tcagtatgga aattatgtaa tccaacatgt cctggagcat ggtcgtcctg
     3301 aggataaaag caaaattgta gcagagatcc gaggcaatgt acttgtattg agtcagcaca
     3361 aattcgcaag caatgttgtg gagaagtgtg tcactcacgc ctcacgtaca gagcgtgctg
     3421 tgctcattga tgaggtatgc accatgaatg acggtcccca cagtgcctta tacaccatga
     3481 tgaaggatca gtatgccaat tatgtggtcc agaagatgat cgatgtggct gagccggggc
     3541 agcggaagat tgtcatgcac aagatccggc cacacatcgc gactcttcgg aagtacacct
     3601 atggcaagca catcctggcc aagcttgaga agtactacat gaagaatggt gtggacttgg
     3661 ggcccatttg tggtccccct aatgggatca tctgagcagt gcacccatcc ctgtcccgct
     3721 gacctcactg accctggcag atccaaccag caaccagaga tgcccagctc agagtcgaaa
     3781 gtgggcgatg gttgctccgg gattgctccc tcctccaaaa atggaatcgg atccacttgt
     3841 ggaaaggcct ttgtaaattt cattttatta cacataacat gtactaatta ttttttttaa
     3901 ttgactaatt gccctgctgt ttactggtgt ataggaactt gtacataggt aatcagtgta
     3961 catgagaggc cacatgcttt gttcaatgtt gtatctatat tccacatgtg gacactttca
     4021 gggtggttgg tttaacaaaa aaagttttaa aaaaagacaa aaaaaggttt ttaactcatt
     4081 tgccttgtgg caagttttgc aaatagctct tccccacccc attttattaa aaaaagaaac
     4141 ctgagaaatt tgaattttag ttaaataatc tcaaactggc atttaacact gtttataaaa
     4201 tatatatata tatatacata tatacatatg aaatgggaac gtttccgagt tgctaaagca
     4261 tcagcctgtg atacggagtt tatgacgctc tttggagatg acctcatgct gagggaggtg
     4321 gtagctgcag atccaggagg agcgggaagc acagagacag gccggaggcc agtgggcatg
     4381 gccacttgct ctatgggttg ccttctgtga acactgggaa gcagaatctg attatctagc
     4441 atgagagaac ccagctctgc tcctggtctg gcttctatag atacatagtg tatacttgtg
     4501 tagactttgc atatatacgg atttgtagta ttttcctgtt ttgatgtcta atctgtatct
     4561 ataatgtacc ctagtagtcg gacatacttt tgattgtaca attgtacatt tgtatacctg
     4621 taatgtaaat gtggagaagt ttgaatcaac atgaacacgt ttttggtaag aagagaaccg
     4681 gccagcccgt gcactctgta tatcccacct tttatggttg tagcagatag tgttgtatat
     4741 tgtaaattgt aatttcaaac agaagtaaat ttttttcttt tgaaggaata aatgttcttt
     4801 atacagccta gttaatgttt aaaaagaaaa aatagcttgg tttatttgtc agctagtcaa
     4861 gacggtagtg agagcctttc taaatgttac ttcagatgat tcagttcaca ctagtgttcc
     4921 tttttttttt tttatcctaa gaaaaggtaa tgtttcgctt attttgtgac agtcaaaagg
     4981 atgtgcagaa gtttcgcctg ccccttccct gctcaccacc tccccttgta aagtgactca
     5041 ccctccgttt tgtacagatg agctgtattt tgcattttgt ctacttgtaa gtgaatgtaa
     5101 catactgtca atcctcgttt gaatatagac tgtaacacta cacggtgtac atttccagag
     5161 ccttgtgtat atttccaatg aactttttgc aagcacactt gtaaccatat gtgtataatt
     5221 aacaaacctg tgtatgctta tgcctgggca actatttttt gtaactcttg tgtagattgt
     5281 ctctaaacaa tgtgtgatct ttattttgaa aaaaatacag aactttggaa tctgaa
//
LOCUS       NM_001437022            2030 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 8, mRNA.
ACCESSION   NM_001437022 XM_006252622
VERSION     NM_001437022.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2030)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2030)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2030)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2030)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252622.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.51999.1,
                                           SRR26643285.49875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-405             JAXUCZ010000016.1  6894275-6894533
            406-555             JAXUCZ010000016.1  6898222-6898371
            556-2030            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2030
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..405
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1728
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 8; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423951.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     163..237
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     238..1725
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    268..1179
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    268..1179
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(430..432,730..732,742..744,748..750,829..834,
                     838..843,907..909)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(430..432,730..732,742..744,748..750,829..834,
                     838..843,907..909)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(430..432,730..732,829..831)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(430..432,730..732,829..831)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    544..546
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    703..705
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(733..747,766..774,832..834,838..852,859..864,
                     925..930,934..942,946..951,1021..1026,1165..1179)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(733..747,766..774,832..834,838..852,859..864,
                     925..930,934..942,946..951,1021..1026,1165..1179)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1273..1722
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1273..1722
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1300..1302
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            406..555
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2030
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagattt acggtctgca ttatgtctgg agcccgcact
      181 gcgcatgcgc tcgtcttcct cctcggctgt tctgcgcttg cgttgggcgt ctgctcagcc
      241 tccctggagc acggcgaggc tgagtactac gtggctgccg tgtacgaaca ccgatcggtc
      301 ctgagcccaa accccctgga gctcagcagc cgccagcagg ccctggagct catgaagcag
      361 aacctcgacg tctatgaaca gcaagtgatg gctgcagccc agaagggtgc gcacattata
      421 gtgttcccag aagacggtat ccacggattc aacttcacaa gaacatccat ttacccattc
      481 ttggacttga tgccatctcc caggctggtc agttggaacc cgtgtctgga gccctttcgc
      541 ttcaatgaca cggaggtcct ccagcgcctg agttgcatgg ccatcaaggg aaagatgttc
      601 ttggtggcca atcttgggac aaaacagcct tgcctcggca gcgaccctgg gtgcccgcag
      661 gacgggagat accagtttaa cacaaacgtc gcgttcagtg acaacggaac cctcgtcggc
      721 cgctaccgta agcacaacct gtactttgag gaagccttcg atagccctgc tgacgtggac
      781 ctcaccacct ttgatacgcc gttcgcgggc aagttcggta tgttcacttg ctttgatatc
      841 ctgttctttg accccgcggt ccggctcctc agagactttg aggtaaagca cattgcgtac
      901 cctacggcct ggatgaacca gctgccgctc ttggcagcca ttgaaatcca gaaagcattc
      961 gccaccgcct tcggcgtcac cgttctggca gctaacatcc accacccgac tctggggatg
     1021 acgggcagtg gcatacacac ccctctgaag tccttttggt accataacat ggacgacccc
     1081 gaaggtcacc ttataattgc ccgggtagcc acaaacccac agggcctcgt tgggacagag
     1141 aatacaacta gtgaaatgga tccgtcccat aggaagttct taaaagtctt gtctggggat
     1201 ccgtactgtg agaaggatgc ccaggaagtg cgctgcgacg aggctgccaa gtggaacctg
     1261 aacgcaccac ctaccttcca ctcggagatg atgtatgaca atttcaccct ggtccccgtc
     1321 tggggaaagg aaggccacct ccaggtgtgc tccaacagtc tctgttgcca cttacttttc
     1381 gagaggcccg ccctgtccaa agagctatat gccctgggtg tctttgacgg actccacaca
     1441 gtgcacggta cctactacgt tcaagcctgt gccctggtca agtgcggggg cgctggcttt
     1501 gaaacctgcg ggcaggagat ctcggaggcc gagggcttgt ttgactttca tctgtggggg
     1561 aacttcagca ccttgtatgt cttcccttta tttctcacct cggggatgac cctagacacc
     1621 cctgaccagc tcgggtggga gagcgaccac tatttcttga ggaagagggg actgtcctcc
     1681 ggcctggtga cggcagctct ctatgggcgg ttgtatgaga ggaattagga aaactgtggt
     1741 cagcaggttg ggctctgcag gctggccttg ccttcccacg gcccacagat cccaaacact
     1801 gggaaaaccg ccccgcccct gtggcactgg atcccaccct ggggaactgt aagaagatgg
     1861 gagaggcagt tcctccttcc tttctacata atgactgaga tattttctgg tattttctat
     1921 tcacattatt ctttttcaag ccacaccctc ttaccactac tacacaattg gttttaaaga
     1981 ctaagccaaa aaaaaaaaaa aaaaataaac atcagctgcc attctacaaa
//
LOCUS       NM_001437082            5081 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 9, mRNA.
ACCESSION   NM_001437082 XM_017593516
VERSION     NM_001437082.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5081)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5081)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5081)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5081)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5081)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5081)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5081)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5081)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5081)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5081)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_017593516.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.24530.1,
                                           SRR26360194.185885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1470           JAXUCZ010000005.1  148197677-148197781
            1471-1622           JAXUCZ010000005.1  148200975-148201126
            1623-1761           JAXUCZ010000005.1  148203568-148203706
            1762-1905           JAXUCZ010000005.1  148205552-148205695
            1906-2202           JAXUCZ010000005.1  148206678-148206974
            2203-2470           JAXUCZ010000005.1  148218465-148218732
            2471-2600           JAXUCZ010000005.1  148219783-148219912
            2601-2729           JAXUCZ010000005.1  148221617-148221745
            2730-2867           JAXUCZ010000005.1  148225153-148225290
            2868-2993           JAXUCZ010000005.1  148228732-148228857
            2994-3115           JAXUCZ010000005.1  148229514-148229635
            3116-3308           JAXUCZ010000005.1  148231206-148231398
            3309-5081           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5081
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3440
                     /gene="Pum1"
                     /note="isoform 9 is encoded by transcript variant 9;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 9"
                     /protein_id="NP_001424011.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAA
                     TLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGG
                     ASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGAL
                     VVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPL
                     GTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSL
                     GATLGSALGGFGTAGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLR
                     YGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAA
                     ERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYG
                     CRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDA
                     FKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVL
                     EHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGP
                     HSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEK
                     YYMKNGVDLGPICGPPNGII"
     misc_feature    2406..3371
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2406..3371
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2574..2579,2586..2588,2682..2687,2694..2696,
                     2793..2795,2802..2804,2898..2903,2910..2912,2997..3002,
                     3006..3011,3018..3020,3105..3110,3114..3119,3126..3128,
                     3234..3239,3243..3248,3255..3257,3345..3347,3354..3356)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2574..2579,2586..2588,2682..2687,2694..2696,
                     2793..2795,2802..2804,2898..2903,2910..2912,2997..3002,
                     3006..3011,3018..3020,3105..3110,3114..3119,3126..3128,
                     3234..3239,3243..3248,3255..3257,3345..3347,3354..3356)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1622
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1761
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1905
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2202
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2600
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2729
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2867
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2993
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3115
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3308
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..5081
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcgcaggt ttagctcccg
     1381 ctgcgtttgt ccccaaccca tacatcatca gcgctgctcc cccagggacg gacccctaca
     1441 cagctggatt ggctgcagca gcgacactcg gcccagctgt ggtccctcac caatattatg
     1501 gagtcacgcc atggggtgtc tatcctgcta gtcttttcca gcaacaagct gctgcagctg
     1561 cagcagcaac aaattcagct actcagcaga gtgccccaca ggcccagcag ggacagcagc
     1621 aggttcttcg tggaggagct agccagcgtc ctttgacccc aaatcagaac cagcagggac
     1681 aacaaacaga tccccttgta gcagctgcag cagtgaactc tgctcttgcc tttggacaag
     1741 gattggctgc aggtatgcca ggttatccag tcttggcacc tgctgcttac tatgaccaaa
     1801 ctggtgccct tgtggtgaat gcaggggcaa gaaatggcct cggagctcca gttcggcttg
     1861 ttgctccagc cccagtcatc attagctcct cagctgcaca agcagctgtt gcagcggctg
     1921 cagcttcagc aaatggagca gccggtggtc ttgcaggaac tacaaatgga ccatttcgac
     1981 ctttaggcac ccagcagccc cagccccagc cccagcagca gcccagtaac aatctggctt
     2041 ccagctcttt ctatggcaac aactctctga gcagtaactc ccagagcagc tccctcttct
     2101 ctcagggctc cgcccagcct gccaacacgt ccttgggatt cggaagcagc agttcccttg
     2161 gtgccaccct aggatcggcc cttggagggt ttggaacagc aggaggactc acgaacggca
     2221 gtggaagata catctctgct gctcctggtg ccgaagccaa gtaccgcagt gcgagcagtg
     2281 cctccagcct tttcagcccc agcagcaccc ttttttcttc ctctcgtttg agatacggaa
     2341 tgtctgatgt tatgccctct ggcaggagca gacttctgga agactttcga aacaaccggt
     2401 accctaattt acaactgcgg gagattgccg ggcatataat ggaattttcc caagaccagc
     2461 atggttctag attcattcag ctgaaactag agcgagccac agcagctgag cgccagcttg
     2521 tcttcaacga aatcctgcag gctgcgtacc aacttatggt ggatgtgttt ggaaattacg
     2581 tcattcagaa gttctttgaa tttggcagcc atgaacagaa gctggctttg gctgaacgga
     2641 ttcgaggcca cgtcctatca ttggcactgc agatgtatgg ctgccgagtc atccagaaag
     2701 ctttggaatt tattccctca gaccagcaga acgagatggt gcgggagcta gatggccatg
     2761 tcctgaagtg tgtgaaagac cagaatggca accatgtggt tcagaagtgc attgaatgtg
     2821 tacagcccca gtctttgcag ttcatcatcg atgcattcaa ggggcaggtg tttgctttgt
     2881 ctacgcaccc atatggctgt agggtgatcc agaggatcct ggaacactgt ctccccgacc
     2941 agaccctccc tatcctggag gagcttcacc agcacacgga gcagctcgtg caggatcagt
     3001 atggaaatta tgtaatccaa catgtcctgg agcatggtcg tcctgaggat aaaagcaaaa
     3061 ttgtagcaga gatccgaggc aatgtacttg tattgagtca gcacaaattc gcaagcaatg
     3121 ttgtggagaa gtgtgtcact cacgcctcac gtacagagcg tgctgtgctc attgatgagg
     3181 tatgcaccat gaatgacggt ccccacagtg ccttatacac catgatgaag gatcagtatg
     3241 ccaattatgt ggtccagaag atgatcgatg tggctgagcc ggggcagcgg aagattgtca
     3301 tgcacaagat ccggccacac atcgcgactc ttcggaagta cacctatggc aagcacatcc
     3361 tggccaagct tgagaagtac tacatgaaga atggtgtgga cttggggccc atttgtggtc
     3421 cccctaatgg gatcatctga gcagtgcacc catccctgtc ccgctgacct cactgaccct
     3481 ggcagatcca accagcaacc agagatgccc agctcagagt cgaaagtggg cgatggttgc
     3541 tccgggattg ctccctcctc caaaaatgga atcggatcca cttgtggaaa ggcctttgta
     3601 aatttcattt tattacacat aacatgtact aattattttt tttaattgac taattgccct
     3661 gctgtttact ggtgtatagg aacttgtaca taggtaatca gtgtacatga gaggccacat
     3721 gctttgttca atgttgtatc tatattccac atgtggacac tttcagggtg gttggtttaa
     3781 caaaaaaagt tttaaaaaaa gacaaaaaaa ggtttttaac tcatttgcct tgtggcaagt
     3841 tttgcaaata gctcttcccc accccatttt attaaaaaaa gaaacctgag aaatttgaat
     3901 tttagttaaa taatctcaaa ctggcattta acactgttta taaaatatat atatatatat
     3961 acatatatac atatgaaatg ggaacgtttc cgagttgcta aagcatcagc ctgtgatacg
     4021 gagtttatga cgctctttgg agatgacctc atgctgaggg aggtggtagc tgcagatcca
     4081 ggaggagcgg gaagcacaga gacaggccgg aggccagtgg gcatggccac ttgctctatg
     4141 ggttgccttc tgtgaacact gggaagcaga atctgattat ctagcatgag agaacccagc
     4201 tctgctcctg gtctggcttc tatagataca tagtgtatac ttgtgtagac tttgcatata
     4261 tacggatttg tagtattttc ctgttttgat gtctaatctg tatctataat gtaccctagt
     4321 agtcggacat acttttgatt gtacaattgt acatttgtat acctgtaatg taaatgtgga
     4381 gaagtttgaa tcaacatgaa cacgtttttg gtaagaagag aaccggccag cccgtgcact
     4441 ctgtatatcc caccttttat ggttgtagca gatagtgttg tatattgtaa attgtaattt
     4501 caaacagaag taaatttttt tcttttgaag gaataaatgt tctttataca gcctagttaa
     4561 tgtttaaaaa gaaaaaatag cttggtttat ttgtcagcta gtcaagacgg tagtgagagc
     4621 ctttctaaat gttacttcag atgattcagt tcacactagt gttccttttt ttttttttat
     4681 cctaagaaaa ggtaatgttt cgcttatttt gtgacagtca aaaggatgtg cagaagtttc
     4741 gcctgcccct tccctgctca ccacctcccc ttgtaaagtg actcaccctc cgttttgtac
     4801 agatgagctg tattttgcat tttgtctact tgtaagtgaa tgtaacatac tgtcaatcct
     4861 cgtttgaata tagactgtaa cactacacgg tgtacatttc cagagccttg tgtatatttc
     4921 caatgaactt tttgcaagca cacttgtaac catatgtgta taattaacaa acctgtgtat
     4981 gcttatgcct gggcaactat tttttgtaac tcttgtgtag attgtctcta aacaatgtgt
     5041 gatctttatt ttgaaaaaaa tacagaactt tggaatctga a
//
LOCUS       NM_001437042            5197 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transducin (beta)-like 1 X-linked (Tbl1x),
            transcript variant 2, mRNA.
ACCESSION   NM_001437042 XM_039099666
VERSION     NM_001437042.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5197)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   2  (bases 1 to 5197)
  AUTHORS   Oberoi,J., Fairall,L., Watson,P.J., Yang,J.C., Czimmerer,Z.,
            Kampmann,T., Goult,B.T., Greenwood,J.A., Gooch,J.T.,
            Kallenberger,B.C., Nagy,L., Neuhaus,D. and Schwabe,J.W.
  TITLE     Structural basis for the assembly of the SMRT/NCoR core
            transcriptional repression machinery
  JOURNAL   Nat Struct Mol Biol 18 (2), 177-184 (2011)
   PUBMED   21240272
REFERENCE   3  (bases 1 to 5197)
  AUTHORS   Perissi,V., Scafoglio,C., Zhang,J., Ohgi,K.A., Rose,D.W.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     TBL1 and TBLR1 phosphorylation on regulated gene promoters
            overcomes dual CtBP and NCoR/SMRT transcriptional repression
            checkpoints
  JOURNAL   Mol Cell 29 (6), 755-766 (2008)
   PUBMED   18374649
REFERENCE   4  (bases 1 to 5197)
  AUTHORS   Ishii,S., Kurasawa,Y., Wong,J. and Yu-Lee,L.Y.
  TITLE     Histone deacetylase 3 localizes to the mitotic spindle and is
            required for kinetochore-microtubule attachment
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4179-4184 (2008)
   PUBMED   18326024
REFERENCE   5  (bases 1 to 5197)
  AUTHORS   Li,J. and Wang,C.Y.
  TITLE     TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene
            promoter for transcription activation and oncogenesis
  JOURNAL   Nat Cell Biol 10 (2), 160-169 (2008)
   PUBMED   18193033
REFERENCE   6  (bases 1 to 5197)
  AUTHORS   Yoon,H.G., Choi,Y., Cole,P.A. and Wong,J.
  TITLE     Reading and function of a histone code involved in targeting
            corepressor complexes for repression
  JOURNAL   Mol Cell Biol 25 (1), 324-335 (2005)
   PUBMED   15601853
REFERENCE   7  (bases 1 to 5197)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
REFERENCE   8  (bases 1 to 5197)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
REFERENCE   9  (bases 1 to 5197)
  AUTHORS   Guenther,M.G., Lane,W.S., Fischle,W., Verdin,E., Lazar,M.A. and
            Shiekhattar,R.
  TITLE     A core SMRT corepressor complex containing HDAC3 and TBL1, a
            WD40-repeat protein linked to deafness
  JOURNAL   Genes Dev 14 (9), 1048-1057 (2000)
   PUBMED   10809664
REFERENCE   10 (bases 1 to 5197)
  AUTHORS   Bassi,M.T., Ramesar,R.S., Caciotti,B., Winship,I.M., De Grandi,A.,
            Riboni,M., Townes,P.L., Beighton,P., Ballabio,A. and Borsani,G.
  TITLE     X-linked late-onset sensorineural deafness caused by a deletion
            involving OA1 and a novel gene containing WD-40 repeats
  JOURNAL   Am J Hum Genet 64 (6), 1604-1616 (1999)
   PUBMED   10330347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039099666.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.31949.1,
                                           SRR26643285.22342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000021.1  45452800-45453005
            207-301             JAXUCZ010000021.1  45580881-45580975
            302-415             JAXUCZ010000021.1  45588384-45588497
            416-561             JAXUCZ010000021.1  45590125-45590270
            562-823             JAXUCZ010000021.1  45592879-45593140
            824-956             JAXUCZ010000021.1  45594504-45594636
            957-1098            JAXUCZ010000021.1  45594986-45595127
            1099-1162           JAXUCZ010000021.1  45595398-45595461
            1163-1260           JAXUCZ010000021.1  45595575-45595672
            1261-1321           JAXUCZ010000021.1  45596597-45596657
            1322-1443           JAXUCZ010000021.1  45597099-45597220
            1444-1518           JAXUCZ010000021.1  45600082-45600156
            1519-1646           JAXUCZ010000021.1  45600539-45600666
            1647-1812           JAXUCZ010000021.1  45601466-45601631
            1813-1914           JAXUCZ010000021.1  45605242-45605343
            1915-5197           JAXUCZ010000021.1  45606251-45609533
FEATURES             Location/Qualifiers
     source          1..5197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..5197
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="transducin (beta)-like 1 X-linked"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
     exon            1..206
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            207..301
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    259..261
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="upstream in-frame stop codon"
     exon            302..415
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1941
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1X"
                     /protein_id="NP_001423971.1"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
                     /translation="MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLV
                     PPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREK
                     LAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSK
                     PMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG
                     STQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLG
                     QHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT
                     FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK
                     QDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHT
                     LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARG
                     DKVGASASDGSVCVLDLRK"
     misc_feature    376..450
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="Region: LisH; pfam08513"
                     /db_xref="CDD:462501"
     misc_feature    376..450
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="Region: LisH; pfam08513"
                     /db_xref="CDD:462501"
     misc_feature    886..1806
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    886..1806
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    order(898..900,952..954,964..966,982..987,1051..1056,
                     1120..1122,1132..1134,1150..1152,1186..1191,1240..1242,
                     1255..1257,1273..1278,1315..1317,1363..1365,1378..1380,
                     1396..1401,1435..1440,1492..1494,1504..1506,1522..1527,
                     1561..1566,1642..1644,1657..1659,1675..1680,1714..1719,
                     1771..1773,1783..1785,1801..1806)
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    order(898..900,952..954,964..966,982..987,1051..1056,
                     1120..1122,1132..1134,1150..1152,1186..1191,1240..1242,
                     1255..1257,1273..1278,1315..1317,1363..1365,1378..1380,
                     1396..1401,1435..1440,1492..1494,1504..1506,1522..1527,
                     1561..1566,1642..1644,1657..1659,1675..1680,1714..1719,
                     1771..1773,1783..1785,1801..1806)
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    910..1053
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    910..1053
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1081..1188
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1081..1188
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1201..1311
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1201..1311
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1330..1434
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1330..1434
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1450..1560
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1450..1560
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1576..1713
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1576..1713
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    <1726..1938
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="eight-bladed beta-propeller heme-binding domain in
                     cytochrome cd1 and similar proteins; Region:
                     8prop_heme_binding_protein; cl49617"
                     /db_xref="CDD:483957"
     misc_feature    <1726..1938
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="eight-bladed beta-propeller heme-binding domain in
                     cytochrome cd1 and similar proteins; Region:
                     8prop_heme_binding_protein; cl49617"
                     /db_xref="CDD:483957"
     misc_feature    1729..1803
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1729..1803
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1735..1839
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="propeller blade [structural motif]; Region:
                     propeller blade"
                     /db_xref="CDD:467722"
     misc_feature    1735..1839
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="propeller blade [structural motif]; Region:
                     propeller blade"
                     /db_xref="CDD:467722"
     misc_feature    1852..1932
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1852..1932
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            416..561
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            562..823
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            824..956
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1098
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1162
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1260
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1321
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1443
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1518
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1646
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1812
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1914
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..5197
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggttgcat cacgagcggg ctcgggtttt cgatcgtacc cttcgtaata cctcagcatc
       61 agtctgcaca agctcaggag cccaagagct aagaagggca ggctcaaggg agccctacca
      121 agtcctctgg gggtggggtg ggggcttgaa tggcagctga tagctaataa gccagtgttc
      181 tgctgattca caattatgga gactgtggtg gtcctggact ttgtgcacac ctctcaagtt
      241 ctgtgattgg atgctgggta gcccactgct ccagaggtct acacatgcac tcactgtgac
      301 gagggtggct cacacttgat cgagacgaag acctcatcgc cgcaaggtga ggctaagatg
      361 agcattacca gcgacgaggt gaactttctg gtatatcgct acctccagga atcaggtttt
      421 tcccattccg ccttcacgtt tgggatcgaa agccacatta gccagtccaa catcaatggt
      481 acactagtgc caccggctgc cctaatctcc attcttcaga aaggactgca atatgtggag
      541 gcggagatca gcatcaacga ggatggcacg gtatttgatg ggcgtcccat tgagtcccta
      601 tcgttaattg atgctgtgat gcccgatgtg gtacagacaa gacagcaagc ttttcgggag
      661 aagctcgccc aacagcaagc caatgcagca gctgcagcag cagcagccgc agccacagcc
      721 acaagcacag cggccacaac accagcagct gctgctcagc aaaacccacc aaagaatgga
      781 gaagccaccg tgaatgggga agaaaatgga gcccatgcaa taaataatca ctcaaaacca
      841 atggaaatag atggagacgt tgaaattcca ccgagtaaag ccacagtcct tcgaggccat
      901 gagtctgaag tgttcatttg tgcctggaat cctgttagtg acctacttgc ttctggatct
      961 ggagactcta ctgcgaggat atggaacctt aatgagaaca gcaacggggg ctccacacag
     1021 cttgtgctga ggcactgcat ccgtgaaggt ggacatgatg ttcccagtaa taaggatgtc
     1081 acctcattgg actggaatag cgatgggaca ctgttggcaa caggttccta tgatggtttt
     1141 gcaagaatat ggacagaaga tggtaaccta gccagcacct tgggtcaaca caaaggcccc
     1201 atctttgcct tgaagtggaa caaaaagggg aattatattt tgagtgctgg tgtagacaag
     1261 acaacaataa tttgggacgc ccacacagga gaagccaaac aacagtttcc ttttcattca
     1321 gcacctgccc ttgatgtgga ctggcagaac aacactacct ttgcctcgtg cagcacagac
     1381 atgtgcattc atgtgtgcag gcttggctgt gatcgcccag tcaaaacctt ccaaggacat
     1441 actaatgagg tcaatgctat caaatgggat ccttctggaa tgttgctagc ctcctgctct
     1501 gatgacatga cattaaagat ctggagtatg aagcaggatg catgtgtcca tgacctccaa
     1561 gctcacagca aagagatata taccatcaag tggagtccca caggaccagc caccagcaac
     1621 ccgaactcca acatcatgtt agcaagtgct tcatttgact ctacggttcg actgtgggat
     1681 gtggagcgag gcgtttgcat ccacacactg accaagcatc aggagcctgt ctatagtgta
     1741 gcgttcagcc ctgacggaaa gtatttggcc agtggatcct ttgacaagtg tgtccatatc
     1801 tggaatactc agagtggaag tctcgtccac agctaccgag gaacaggcgg catatttgag
     1861 gtgtgctgga atgctcgagg agacaaagtg ggtgccagtg catctgatgg ctctgtctgt
     1921 gttttagatc tccgaaagta aacacaaaat gtagaaaaca aaaccattct aatggagcag
     1981 cagtgaatgt gtgggattgc agcacccttt cctatgatgg gctccaaact gtgtgaactt
     2041 gacttgttcg agtctacttg gaaatcacct gtccctggcc acaggattat ttccccccct
     2101 cccctaatct ccatccagaa gtttaaaaca caaacaaata caaagtcata cgcatggttg
     2161 tatcacagga atatggtttc tacctagaat gctcagctgg ggaaggatga agcaagccat
     2221 cagctacatg gtacatggtt ggtttccatc cagaacaggc tctaatgact gaacagggaa
     2281 ggaagaacac aaagctgtgc caaaaaataa tgaaaaggtt aaaaaatgaa agagaaaaaa
     2341 tgctgtgata aaccaaaagg gaggaaaaac ctgtccctta tggtgtttcc ctcctatcaa
     2401 tttggatact acagttgctc caaaagacca gtttgtacca atgaaatgtg tgactttgta
     2461 atcccaacgc tgtattttct agaaccttct ttggtggttt ttctatctgc taaaattctg
     2521 tggtctgggg gcttcccacc tcagatgaaa actgtttttg gcttattcct tctgtcctcc
     2581 cttgttgttt cccacccctt cctctgatgt ccttgctctg gtgtggtctc acttctaatg
     2641 aaatcctgca tagatatggc cacatgcaca cagtggatct ttgttggaca gcactctcct
     2701 tccctctctc ccactcctac ctattgctta ctctgtccct ttctcatagt tgcttcacat
     2761 taggtcccaa aggcactttc agagcatagt aagtgcttta tgtaagaagg cagggatggg
     2821 gactttttac agaaaaaaaa agacttactt ataagagaaa gaacctggag tattttttga
     2881 aaaaaatatt tttatgttaa aatgacttta aaatcctaaa atggccatca gacatagaga
     2941 gttttgtgaa attcatattt aaaagactaa gaagacactg gcagagtctg aggtgtctaa
     3001 ttaccccttt cccttcagct tcacgaaagg cagttaggca agccgtggat tgggaagcgt
     3061 cctatggaag aacaagggga ttgttttggc agctggtggg gaagaaagag cccactggtt
     3121 aggcatcaag cagaatgctg aactgtttgg tacacatttc cttcagcagc caataggaac
     3181 atagtgaaga agccaccctg accaggtgtg gctcatggca cctgccagct acatctttct
     3241 cacaacagtg tagctacaga tgggcacttt tatcaagagc atgcttggtg aatcttgcaa
     3301 aactgaccca aaggcctcag tgtcactcag tcttgtgaag acagtgagtc tcaagggaga
     3361 ctttcaattg taaaaatgaa ttatgaccca ggtagaatgt cactgatcat ttctgcccac
     3421 tttccaattt ctctgacaga agattaggac aaagctttct tttaaaaaat gagaaaaaaa
     3481 taggaaagaa atttcggcta ttttttaaaa acaaaataag gcatagtgtg cctggtaaag
     3541 tttgccatca ttgaatcagg tggcctttgt tcatttcttg tcataacttg acactgactt
     3601 gtttctttaa ttagtaatag gggacagacc agaagggggc tgcaagaggc agtatgaagg
     3661 gtccagtctg cagctgaggc aagtgttact tagagaaaag tatacatata tgaagccaaa
     3721 aatcaaccag caaggaaggt caggtgctcc ctacacaaca aatgttagca ccaaaacatg
     3781 tattggcctc cactttgcca tgtaaattat gtgagccctc aaaatctaaa gtgttgtgta
     3841 ttgagttgag tggtgaattt gggttctgcc acctaaatgc ttagcaaagt aagcccaagt
     3901 tgtgtggaaa tttgatcata gcagatgtct ctgtgtcagt ggatatgaag ttccctgccc
     3961 tgagactgct tttagcttta ggatgtaatt ttggaagtcc agataaatcc tatcattgtt
     4021 ccacaaatac atttctgttc atctctacag aagatcagct gttagatgtc agcctattgt
     4081 aaaggtatga ctttcatttg acaagttcta cattgctata tggtggtaat gggtaggtgg
     4141 cacatatggg gttcatcaga caatctctgg gtgtccaggc tacacccccc ctagatgaat
     4201 ctaagccaca taagaattat tattttggag tcaatggctg taagactagg acaaaaaggt
     4261 tcaatctaca taaacctgaa gaccattcat ttccctggcc ttacagctaa acatggacag
     4321 gaacttagtg ctggccacac aaggaccaag cagaagaatg cagcccacac ccctgaagtt
     4381 catccccata agacagctca gtctgcagct gtttctggag cggccagcat ttggacgcca
     4441 tcatttgcct gctgttacag ggcaggtgca tcatctttgt gatcaagggg tggcccatgt
     4501 gttatgctgt tacctaacat tgtttataac tcctaaaaac attgtgagga atggttagtc
     4561 ttgtgaccaa attcaacctt gaaagcagtg tagtcacata gcagcctttc caggtaattt
     4621 tccttgagtt tgaagtaacc atataccatt cctagcacat ccaggatgct gcctgtagag
     4681 gaccgaaggg ccagatggac attacaaagt tcaactctct gaccccactc aacaccatag
     4741 gacttgactt tttgttctgt ctgactaaga aatagaccat ggagccaagt gaagtgcact
     4801 ttgtcacatg taaggatctg ctttgttcct tgttgctttt ccctttataa acctttgtta
     4861 tatctttcca ttctgtttct tgtcaaatgc ataaatgtct gttctgcaac tcactgaagt
     4921 tttgaattct ggcttgtgca gtttttattg tctgtgtcag acgtacagcc agacatggtc
     4981 ctctttcaac attttccaca ttctgttaag caccatcaaa actcccctcc ccctctgtcc
     5041 tctcccccac ccccactccc attcacccca cacgctcttc gagaagaaaa aaaaaagaat
     5101 caccttgtgt gttgtagctc atttgtttca agagagaatc aacagatcat attcagtgtc
     5161 ttgaataaat tgctctattt tgatattaga gaacata
//
LOCUS       NM_001030052             540 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S5
            (Ndufs5), transcript variant 2, mRNA.
ACCESSION   NM_001030052 XM_342907
VERSION     NM_001030052.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 540)
  AUTHORS   Huang,G., Chen,Y., Lu,H. and Cao,X.
  TITLE     Coupling mitochondrial respiratory chain to cell death: an
            essential role of mitochondrial complex I in the interferon-beta
            and retinoic acid-induced cancer cell death
  JOURNAL   Cell Death Differ 14 (2), 327-337 (2007)
   PUBMED   16826196
REFERENCE   4  (bases 1 to 540)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 540)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 540)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001030052.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB716681.1, BC168721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000005.1  141264311-141264418 c
            109-326             JAXUCZ010000005.1  141261991-141262208 c
            327-540             JAXUCZ010000005.1  141258828-141259041 c
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..540
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="NADH:ubiquinone oxidoreductase subunit S5"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
     exon            1..108
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="upstream in-frame stop codon"
     exon            109..326
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..431
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 5b,
                     15kDa (NADH-coenzyme Q reductase)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 5"
                     /protein_id="NP_001025223.1"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
                     /translation="MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECA
                     HGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLMKEGKYTPPPHHLGKE
                     EPRP"
     misc_feature    111..398
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     misc_feature    111..398
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     exon            327..540
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtctgc gtcctcctta agccggcggt cgtgagctgc gcccagggac ctgagaaggg
       61 cattgctgag gtgcggtagg cgcttgctgt gtccggtcag ccaagaagtc atgcctttcc
      121 ttgatgtgca gaaaaggctg ggcattagcc tagatcgaca ctttatattc ctaagtgctg
      181 agcagcctta caagaatgcc gctcgatgcc acgcatttga aaaggagtgg atagaatgcg
      241 cacatgggat cggtgctacc cgggctaaaa aagagtgcaa gatagagtat gaagactttg
      301 aagaatgctt tcttcggttc aaaacgataa ggcggatgca tgaaatcaag aaacagcggg
      361 agaagctgat gaaagagggg aagtacaccc ctccgcctca ccatttgggc aaggaggagc
      421 ccaggccctg agcagagcag ctagaagctg ctctccatgc tctgttttcc gctggagaga
      481 atgtttaagg gaagcacctt catcaagtat gtacaaataa agaattactc aacctagaaa
//
LOCUS       NM_001437016            1997 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 2, mRNA.
ACCESSION   NM_001437016 XM_006252610
VERSION     NM_001437016.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252610.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.431981.1,
                                           SRR26643295.51997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-113              JAXUCZ010000016.1  6893598-6893642
            114-372             JAXUCZ010000016.1  6894275-6894533
            373-522             JAXUCZ010000016.1  6898222-6898371
            523-1997            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1997
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..113
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1695
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_001423945.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MRRIFFPKRFTVCIMSGARTAHALVFLLGCSALALGVCSASLEH
                     GEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVF
                     PEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMF
                     LVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPAD
                     VDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEI
                     QKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQ
                     GLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY
                     DNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQAC
                     ALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWES
                     DHYFLRKRGLSSGLVTAALYGRLYERN"
     sig_peptide     88..198
                     /gene="Btd"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    235..1146
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    235..1146
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(397..399,697..699,709..711,715..717,796..801,
                     805..810,874..876)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(397..399,697..699,709..711,715..717,796..801,
                     805..810,874..876)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(397..399,697..699,796..798)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(397..399,697..699,796..798)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(700..714,733..741,799..801,805..819,826..831,
                     892..897,901..909,913..918,988..993,1132..1146)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(700..714,733..741,799..801,805..819,826..831,
                     892..897,901..909,913..918,988..993,1132..1146)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1240..1689
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1240..1689
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            114..372
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            373..522
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1997
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagaa aatcccatgt taccactatg agaaggattt tctttccaaa gcgatttacg
      121 gtctgcatta tgtctggagc ccgcactgcg catgcgctcg tcttcctcct cggctgttct
      181 gcgcttgcgt tgggcgtctg ctcagcctcc ctggagcacg gcgaggctga gtactacgtg
      241 gctgccgtgt acgaacaccg atcggtcctg agcccaaacc ccctggagct cagcagccgc
      301 cagcaggccc tggagctcat gaagcagaac ctcgacgtct atgaacagca agtgatggct
      361 gcagcccaga agggtgcgca cattatagtg ttcccagaag acggtatcca cggattcaac
      421 ttcacaagaa catccattta cccattcttg gacttgatgc catctcccag gctggtcagt
      481 tggaacccgt gtctggagcc ctttcgcttc aatgacacgg aggtcctcca gcgcctgagt
      541 tgcatggcca tcaagggaaa gatgttcttg gtggccaatc ttgggacaaa acagccttgc
      601 ctcggcagcg accctgggtg cccgcaggac gggagatacc agtttaacac aaacgtcgcg
      661 ttcagtgaca acggaaccct cgtcggccgc taccgtaagc acaacctgta ctttgaggaa
      721 gccttcgata gccctgctga cgtggacctc accacctttg atacgccgtt cgcgggcaag
      781 ttcggtatgt tcacttgctt tgatatcctg ttctttgacc ccgcggtccg gctcctcaga
      841 gactttgagg taaagcacat tgcgtaccct acggcctgga tgaaccagct gccgctcttg
      901 gcagccattg aaatccagaa agcattcgcc accgccttcg gcgtcaccgt tctggcagct
      961 aacatccacc acccgactct ggggatgacg ggcagtggca tacacacccc tctgaagtcc
     1021 ttttggtacc ataacatgga cgaccccgaa ggtcacctta taattgcccg ggtagccaca
     1081 aacccacagg gcctcgttgg gacagagaat acaactagtg aaatggatcc gtcccatagg
     1141 aagttcttaa aagtcttgtc tggggatccg tactgtgaga aggatgccca ggaagtgcgc
     1201 tgcgacgagg ctgccaagtg gaacctgaac gcaccaccta ccttccactc ggagatgatg
     1261 tatgacaatt tcaccctggt ccccgtctgg ggaaaggaag gccacctcca ggtgtgctcc
     1321 aacagtctct gttgccactt acttttcgag aggcccgccc tgtccaaaga gctatatgcc
     1381 ctgggtgtct ttgacggact ccacacagtg cacggtacct actacgttca agcctgtgcc
     1441 ctggtcaagt gcgggggcgc tggctttgaa acctgcgggc aggagatctc ggaggccgag
     1501 ggcttgtttg actttcatct gtgggggaac ttcagcacct tgtatgtctt ccctttattt
     1561 ctcacctcgg ggatgaccct agacacccct gaccagctcg ggtgggagag cgaccactat
     1621 ttcttgagga agaggggact gtcctccggc ctggtgacgg cagctctcta tgggcggttg
     1681 tatgagagga attaggaaaa ctgtggtcag caggttgggc tctgcaggct ggccttgcct
     1741 tcccacggcc cacagatccc aaacactggg aaaaccgccc cgcccctgtg gcactggatc
     1801 ccaccctggg gaactgtaag aagatgggag aggcagttcc tccttccttt ctacataatg
     1861 actgagatat tttctggtat tttctattca cattattctt tttcaagcca caccctctta
     1921 ccactactac acaattggtt ttaaagacta agccaaaaaa aaaaaaaaaa aataaacatc
     1981 agctgccatt ctacaaa
//
LOCUS       NM_001437088            5036 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 12, mRNA.
ACCESSION   NM_001437088 XM_063288041
VERSION     NM_001437088.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5036)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5036)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5036)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5036)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5036)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5036)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5036)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5036)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5036)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.23334.1,
                                           SRR26643287.14444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-712             JAXUCZ010000005.1  148181206-148181372
            713-983             JAXUCZ010000005.1  148183570-148183840
            984-1077            JAXUCZ010000005.1  148195258-148195351
            1078-1182           JAXUCZ010000005.1  148197677-148197781
            1183-1334           JAXUCZ010000005.1  148200975-148201126
            1335-1473           JAXUCZ010000005.1  148203568-148203706
            1474-1617           JAXUCZ010000005.1  148205552-148205695
            1618-1914           JAXUCZ010000005.1  148206678-148206974
            1915-2151           JAXUCZ010000005.1  148208059-148208295
            2152-2419           JAXUCZ010000005.1  148218465-148218732
            2420-2549           JAXUCZ010000005.1  148219783-148219912
            2550-2684           JAXUCZ010000005.1  148221617-148221751
            2685-2822           JAXUCZ010000005.1  148225153-148225290
            2823-2948           JAXUCZ010000005.1  148228732-148228857
            2949-3070           JAXUCZ010000005.1  148229514-148229635
            3071-3263           JAXUCZ010000005.1  148231206-148231398
            3264-5036           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5036
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3395
                     /gene="Pum1"
                     /note="isoform 12 is encoded by transcript variant 12;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 12"
                     /protein_id="NP_001424017.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEGPRDADSDENDKGEKK
                     NKGAFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGP
                     NQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSA
                     AATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPY
                     IISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNS
                     ATQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAA
                     GMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAA
                     SANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLF
                     SQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKR
                     TSSSLAPIGHSFYNSLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGL
                     TNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLED
                     FRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLM
                     VDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQV
                     INEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGC
                     RVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEI
                     RGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANY
                     VVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGP
                     PNGII"
     misc_feature    2355..3326
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2355..3326
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2523..2528,2535..2537,2631..2636,2643..2645,
                     2748..2750,2757..2759,2853..2858,2865..2867,2952..2957,
                     2961..2966,2973..2975,3060..3065,3069..3074,3081..3083,
                     3189..3194,3198..3203,3210..3212,3300..3302,3309..3311)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2523..2528,2535..2537,2631..2636,2643..2645,
                     2748..2750,2757..2759,2853..2858,2865..2867,2952..2957,
                     2961..2966,2973..2975,3060..3065,3069..3074,3081..3083,
                     3189..3194,3198..3203,3210..3212,3300..3302,3309..3311)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..712
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1182
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1334
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1473
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1617
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1914
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2151
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2419
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2549
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2684
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2822
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2948
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3070
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3263
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..5036
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagggccc aagggatgca gacagtgatg aaaacgacaa aggtgaaaag aagaacaagg
      601 gtgcgtttga tggagataag ctaggagatt tgaaggagga gggagatgtg atggacaaga
      661 ccaatggttt gccagtgcag aatgggattg atgcagacgt caaagatttt agccgtaccc
      721 ctggtaattg ccagagctct gctaatgaag tggatcttct gggtccaaac cagaatggtt
      781 ctgagggctt agcccagctg accagcacca atggtgccaa gcctgtggag gatttctcca
      841 acatggagtc ccagagtgtc cccttggacc ccatggaaca tgtgggcatg gagcctctgc
      901 agtttgatta ttcaggcacg caggtacctg tggactcagc agcagcaaca gtgggacttt
      961 ttgactacaa ttctcaacaa cagctattcc aaagacccaa tgcgcttgct gttcagcagt
     1021 tgacagctgc ccagcagcag caatatgcac ttgcagcagc ccaccagcct cacatcgcag
     1081 gtttagctcc cgctgcgttt gtccccaacc catacatcat cagcgctgct cccccaggga
     1141 cggaccccta cacagctgga ttggctgcag cagcgacact cggcccagct gtggtccctc
     1201 accaatatta tggagtcacg ccatggggtg tctatcctgc tagtcttttc cagcaacaag
     1261 ctgctgcagc tgcagcagca acaaattcag ctactcagca gagtgcccca caggcccagc
     1321 agggacagca gcaggttctt cgtggaggag ctagccagcg tcctttgacc ccaaatcaga
     1381 accagcaggg acaacaaaca gatccccttg tagcagctgc agcagtgaac tctgctcttg
     1441 cctttggaca aggattggct gcaggtatgc caggttatcc agtcttggca cctgctgctt
     1501 actatgacca aactggtgcc cttgtggtga atgcaggggc aagaaatggc ctcggagctc
     1561 cagttcggct tgttgctcca gccccagtca tcattagctc ctcagctgca caagcagctg
     1621 ttgcagcggc tgcagcttca gcaaatggag cagccggtgg tcttgcagga actacaaatg
     1681 gaccatttcg acctttaggc acccagcagc cccagcccca gccccagcag cagcccagta
     1741 acaatctggc ttccagctct ttctatggca acaactctct gagcagtaac tcccagagca
     1801 gctccctctt ctctcagggc tccgcccagc ctgccaacac gtccttggga ttcggaagca
     1861 gcagttccct tggtgccacc ctaggatcgg cccttggagg gtttggaaca gcagttgcaa
     1921 actccaacac tggcagtggc tcccgccgtg actccctgac tggcagcagt gacctttata
     1981 agaggacatc gagcagcttg gcccccattg gacacagttt ttataacagc cttagctttt
     2041 cctcctctcc tggacccgtg ggcatgcctc tccctagtca gggaccagga cattcacaga
     2101 caccacctcc ttccctctct tcacatggat cctcttcaag cttaaacctg ggaggactca
     2161 cgaacggcag tggaagatac atctctgctg ctcctggtgc cgaagccaag taccgcagtg
     2221 cgagcagtgc ctccagcctt ttcagcccca gcagcaccct tttttcttcc tctcgtttga
     2281 gatacggaat gtctgatgtt atgccctctg gcaggagcag acttctggaa gactttcgaa
     2341 acaaccggta ccctaattta caactgcggg agattgccgg gcatataatg gaattttccc
     2401 aagaccagca tggttctaga ttcattcagc tgaaactaga gcgagccaca gcagctgagc
     2461 gccagcttgt cttcaacgaa atcctgcagg ctgcgtacca acttatggtg gatgtgtttg
     2521 gaaattacgt cattcagaag ttctttgaat ttggcagcca tgaacagaag ctggctttgg
     2581 ctgaacggat tcgaggccac gtcctatcat tggcactgca gatgtatggc tgccgagtca
     2641 tccagaaagc tttggaattt attccctcag accagcaggt aattaacgag atggtgcggg
     2701 agctagatgg ccatgtcctg aagtgtgtga aagaccagaa tggcaaccat gtggttcaga
     2761 agtgcattga atgtgtacag ccccagtctt tgcagttcat catcgatgca ttcaaggggc
     2821 aggtgtttgc tttgtctacg cacccatatg gctgtagggt gatccagagg atcctggaac
     2881 actgtctccc cgaccagacc ctccctatcc tggaggagct tcaccagcac acggagcagc
     2941 tcgtgcagga tcagtatgga aattatgtaa tccaacatgt cctggagcat ggtcgtcctg
     3001 aggataaaag caaaattgta gcagagatcc gaggcaatgt acttgtattg agtcagcaca
     3061 aattcgcaag caatgttgtg gagaagtgtg tcactcacgc ctcacgtaca gagcgtgctg
     3121 tgctcattga tgaggtatgc accatgaatg acggtcccca cagtgcctta tacaccatga
     3181 tgaaggatca gtatgccaat tatgtggtcc agaagatgat cgatgtggct gagccggggc
     3241 agcggaagat tgtcatgcac aagatccggc cacacatcgc gactcttcgg aagtacacct
     3301 atggcaagca catcctggcc aagcttgaga agtactacat gaagaatggt gtggacttgg
     3361 ggcccatttg tggtccccct aatgggatca tctgagcagt gcacccatcc ctgtcccgct
     3421 gacctcactg accctggcag atccaaccag caaccagaga tgcccagctc agagtcgaaa
     3481 gtgggcgatg gttgctccgg gattgctccc tcctccaaaa atggaatcgg atccacttgt
     3541 ggaaaggcct ttgtaaattt cattttatta cacataacat gtactaatta ttttttttaa
     3601 ttgactaatt gccctgctgt ttactggtgt ataggaactt gtacataggt aatcagtgta
     3661 catgagaggc cacatgcttt gttcaatgtt gtatctatat tccacatgtg gacactttca
     3721 gggtggttgg tttaacaaaa aaagttttaa aaaaagacaa aaaaaggttt ttaactcatt
     3781 tgccttgtgg caagttttgc aaatagctct tccccacccc attttattaa aaaaagaaac
     3841 ctgagaaatt tgaattttag ttaaataatc tcaaactggc atttaacact gtttataaaa
     3901 tatatatata tatatacata tatacatatg aaatgggaac gtttccgagt tgctaaagca
     3961 tcagcctgtg atacggagtt tatgacgctc tttggagatg acctcatgct gagggaggtg
     4021 gtagctgcag atccaggagg agcgggaagc acagagacag gccggaggcc agtgggcatg
     4081 gccacttgct ctatgggttg ccttctgtga acactgggaa gcagaatctg attatctagc
     4141 atgagagaac ccagctctgc tcctggtctg gcttctatag atacatagtg tatacttgtg
     4201 tagactttgc atatatacgg atttgtagta ttttcctgtt ttgatgtcta atctgtatct
     4261 ataatgtacc ctagtagtcg gacatacttt tgattgtaca attgtacatt tgtatacctg
     4321 taatgtaaat gtggagaagt ttgaatcaac atgaacacgt ttttggtaag aagagaaccg
     4381 gccagcccgt gcactctgta tatcccacct tttatggttg tagcagatag tgttgtatat
     4441 tgtaaattgt aatttcaaac agaagtaaat ttttttcttt tgaaggaata aatgttcttt
     4501 atacagccta gttaatgttt aaaaagaaaa aatagcttgg tttatttgtc agctagtcaa
     4561 gacggtagtg agagcctttc taaatgttac ttcagatgat tcagttcaca ctagtgttcc
     4621 tttttttttt tttatcctaa gaaaaggtaa tgtttcgctt attttgtgac agtcaaaagg
     4681 atgtgcagaa gtttcgcctg ccccttccct gctcaccacc tccccttgta aagtgactca
     4741 ccctccgttt tgtacagatg agctgtattt tgcattttgt ctacttgtaa gtgaatgtaa
     4801 catactgtca atcctcgttt gaatatagac tgtaacacta cacggtgtac atttccagag
     4861 ccttgtgtat atttccaatg aactttttgc aagcacactt gtaaccatat gtgtataatt
     4921 aacaaacctg tgtatgctta tgcctgggca actatttttt gtaactcttg tgtagattgt
     4981 ctctaaacaa tgtgtgatct ttattttgaa aaaaatacag aactttggaa tctgaa
//
LOCUS       NM_001437024            2465 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 10, mRNA.
ACCESSION   NM_001437024 XM_039094454
VERSION     NM_001437024.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2465)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2465)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2465)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039094454.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.561000.1,
                                           SRR26360186.2718100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-219             JAXUCZ010000016.1  6871948-6872020
            220-581             JAXUCZ010000016.1  6893598-6893959
            582-840             JAXUCZ010000016.1  6894275-6894533
            841-990             JAXUCZ010000016.1  6898222-6898371
            991-2465            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2465
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..219
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            220..581
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    475..477
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            582..840
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..2163
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 10; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423953.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     598..672
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     673..2160
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    703..1614
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    703..1614
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(865..867,1165..1167,1177..1179,1183..1185,
                     1264..1269,1273..1278,1342..1344)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(865..867,1165..1167,1177..1179,1183..1185,
                     1264..1269,1273..1278,1342..1344)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(865..867,1165..1167,1264..1266)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(865..867,1165..1167,1264..1266)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    979..981
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    1138..1140
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(1168..1182,1201..1209,1267..1269,1273..1287,
                     1294..1299,1360..1365,1369..1377,1381..1386,1456..1461,
                     1600..1614)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(1168..1182,1201..1209,1267..1269,1273..1287,
                     1294..1299,1360..1365,1369..1377,1381..1386,1456..1461,
                     1600..1614)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1708..2157
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1708..2157
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1735..1737
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            841..990
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2465
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagccca ggccctccag cactggttaa tagtcatctt
      181 cattcgtccc tcgaagacgt gcccacagac cagcccaaca aaatcccatg ttaccactat
      241 gagaaggatt ttctttccaa agcggtacgt ccttaagcaa gtgattcgga gtagcagaca
      301 aagcagaaaa cagtgaaagc cgtgtgcggg actctgacag ggagacttct ttatggctgc
      361 cctgtgggtg acacagcaga tgctagaatt ccaaaccgcc ccaaataaaa actgaagaat
      421 atcggctagg aagctgccct gcgttcggga gcctcaggac catcgcggct gtcctagagg
      481 gctgacctgc aatgctatgt atgtaagaag actcgagcaa agcatcatca aatatatcgc
      541 agaattgtgt ccaaatttca gcccagttcc tgcggcgcag gatttacggt ctgcattatg
      601 tctggagccc gcactgcgca tgcgctcgtc ttcctcctcg gctgttctgc gcttgcgttg
      661 ggcgtctgct cagcctccct ggagcacggc gaggctgagt actacgtggc tgccgtgtac
      721 gaacaccgat cggtcctgag cccaaacccc ctggagctca gcagccgcca gcaggccctg
      781 gagctcatga agcagaacct cgacgtctat gaacagcaag tgatggctgc agcccagaag
      841 ggtgcgcaca ttatagtgtt cccagaagac ggtatccacg gattcaactt cacaagaaca
      901 tccatttacc cattcttgga cttgatgcca tctcccaggc tggtcagttg gaacccgtgt
      961 ctggagccct ttcgcttcaa tgacacggag gtcctccagc gcctgagttg catggccatc
     1021 aagggaaaga tgttcttggt ggccaatctt gggacaaaac agccttgcct cggcagcgac
     1081 cctgggtgcc cgcaggacgg gagataccag tttaacacaa acgtcgcgtt cagtgacaac
     1141 ggaaccctcg tcggccgcta ccgtaagcac aacctgtact ttgaggaagc cttcgatagc
     1201 cctgctgacg tggacctcac cacctttgat acgccgttcg cgggcaagtt cggtatgttc
     1261 acttgctttg atatcctgtt ctttgacccc gcggtccggc tcctcagaga ctttgaggta
     1321 aagcacattg cgtaccctac ggcctggatg aaccagctgc cgctcttggc agccattgaa
     1381 atccagaaag cattcgccac cgccttcggc gtcaccgttc tggcagctaa catccaccac
     1441 ccgactctgg ggatgacggg cagtggcata cacacccctc tgaagtcctt ttggtaccat
     1501 aacatggacg accccgaagg tcaccttata attgcccggg tagccacaaa cccacagggc
     1561 ctcgttggga cagagaatac aactagtgaa atggatccgt cccataggaa gttcttaaaa
     1621 gtcttgtctg gggatccgta ctgtgagaag gatgcccagg aagtgcgctg cgacgaggct
     1681 gccaagtgga acctgaacgc accacctacc ttccactcgg agatgatgta tgacaatttc
     1741 accctggtcc ccgtctgggg aaaggaaggc cacctccagg tgtgctccaa cagtctctgt
     1801 tgccacttac ttttcgagag gcccgccctg tccaaagagc tatatgccct gggtgtcttt
     1861 gacggactcc acacagtgca cggtacctac tacgttcaag cctgtgccct ggtcaagtgc
     1921 gggggcgctg gctttgaaac ctgcgggcag gagatctcgg aggccgaggg cttgtttgac
     1981 tttcatctgt gggggaactt cagcaccttg tatgtcttcc ctttatttct cacctcgggg
     2041 atgaccctag acacccctga ccagctcggg tgggagagcg accactattt cttgaggaag
     2101 aggggactgt cctccggcct ggtgacggca gctctctatg ggcggttgta tgagaggaat
     2161 taggaaaact gtggtcagca ggttgggctc tgcaggctgg ccttgccttc ccacggccca
     2221 cagatcccaa acactgggaa aaccgccccg cccctgtggc actggatccc accctgggga
     2281 actgtaagaa gatgggagag gcagttcctc cttcctttct acataatgac tgagatattt
     2341 tctggtattt tctattcaca ttattctttt tcaagccaca ccctcttacc actactacac
     2401 aattggtttt aaagactaag ccaaaaaaaa aaaaaaaaaa taaacatcag ctgccattct
     2461 acaaa
//
LOCUS       NM_001437098            7547 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            22, mRNA.
ACCESSION   NM_001437098 XM_039097159
VERSION     NM_001437098.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7547)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7547)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7547)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7547)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7547)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7547)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7547)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7547)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7547)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7547)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097159.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.60178.1,
                                           SRR26643299.63242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-651             JAXUCZ010000018.1  65219645-65219736
            652-724             JAXUCZ010000018.1  65221421-65221493
            725-786             JAXUCZ010000018.1  65334541-65334602
            787-883             JAXUCZ010000018.1  65337982-65338078
            884-945             JAXUCZ010000018.1  65391770-65391831
            946-1075            JAXUCZ010000018.1  65437939-65438068
            1076-1125           JAXUCZ010000018.1  65438528-65438577
            1126-1231           JAXUCZ010000018.1  65507173-65507278
            1232-1362           JAXUCZ010000018.1  65511025-65511155
            1363-1495           JAXUCZ010000018.1  65516916-65517048
            1496-1563           JAXUCZ010000018.1  65525175-65525242
            1564-1642           JAXUCZ010000018.1  65526319-65526397
            1643-1719           JAXUCZ010000018.1  65528841-65528917
            1720-1923           JAXUCZ010000018.1  65531547-65531750
            1924-2059           JAXUCZ010000018.1  65551334-65551469
            2060-2222           JAXUCZ010000018.1  65553405-65553567
            2223-2452           JAXUCZ010000018.1  65556812-65557041
            2453-2593           JAXUCZ010000018.1  65557878-65558018
            2594-7547           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7547
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    511..513
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            560..651
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             580..2589
                     /gene="Tcf4"
                     /note="isoform 21 is encoded by transcript variant 22;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 21"
                     /protein_id="NP_001424027.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLD
                     DAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVG
                     AHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS
                     SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKE
                     RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR
                     ERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    982..>1467
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    982..>1467
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2257..2511
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2257..2511
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2281..2283,2293..2295,2299..2307,2311..2313,
                     2326..2328,2389..2394)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2281..2283,2293..2295,2299..2307,2311..2313,
                     2326..2328,2389..2394)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2320..2325,2332..2337,2341..2346,2353..2355,
                     2365..2367,2395..2397,2404..2406,2416..2418,2425..2427,
                     2434..2451)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2320..2325,2332..2337,2341..2346,2353..2355,
                     2365..2367,2395..2397,2404..2406,2416..2418,2425..2427,
                     2434..2451)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            652..724
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..786
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            787..883
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..945
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1075
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1125
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1231
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1362
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1495
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1563
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1642
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1719
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1923
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2059
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2222
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2452
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2593
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..7547
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaagg tttgtgtgat tttgctaaaa tgcatcacca acagcgaatg
      601 gctgccttag ggacggacaa agagctgagt gatttactgg atttcagtgc gatgttttcg
      661 cctcctgtaa gcagtgggaa aaatggacca acttctttgg cgagtggaca ttttacgggc
      721 tcaaatgtag aagacagaag tagctcaggg tcctggggga atggaggtca tccaagcccg
      781 tccaggaact atggagatgg gactccctat gaccacatga ctagcaggga tcttgggtca
      841 catgacaatc tctctccacc ttttgtcaat tccagaatac aaagtaaaac agaaaggggt
      901 tcatactcat cttatgggag agaaaacgta cagggttgcc accagcagag tctcctcgga
      961 ggggacatgg atatgggcaa cccaggaacc ctttcgccca ccaaacctgg ctcccagtac
     1021 tacccatatt ccagcaataa cgcccgacgg aggcctcttc acagtagtac catggaggtg
     1081 cagacaaaga aagtcagaaa agttcctcca ggcttgccat cttcagtcta cgctccttca
     1141 gccagcactg ccgactacaa cagggactca ccaggctatt cttcctccaa gccagcagcc
     1201 agcactttct ccagctcctt cttcatgcaa gatggccatc acagcagtga cccttggagc
     1261 tcctccagtg gaatgaatca gcccggctat ggagggatgc taggcaactc tcatatccca
     1321 cagtctagca gctactgtag cctgcatcca catgaacgtc tgagctatcc atcgcactcc
     1381 tcggcagaca tcaactccag tcttcctccg atgtccacgt tccatcgaag tggcacaaac
     1441 cattacagca cctcttcctg cacacctcct gccaacggaa cagacagtat aatggcaaac
     1501 agaggaactg gggcagcagg cagctcccag actggagacg ctctggggaa agccctggct
     1561 tcgatctatt ctcctgatca cacgaacaac agcttctcct ccaacccttc aactcctgtt
     1621 ggctcccctc cttcactctc agcaggcaca gctgtttggt ctcgaaacgg aggacaggcc
     1681 tcgtcatctc ccaattacga aggacccttg cactccttgc agagccgaat tgaagaccgt
     1741 ttagaaagac tggacgacgc gattcatgtt ctccggaacc acgcggtggg cccatccaca
     1801 gctgtgcccg gtggccatgg ggacatgcat gggatcatcg gaccctctca caatggagca
     1861 atgggcagtc tgggctcagg atatggaact ggccttctct cagccaacag acattcactc
     1921 atggtcgggg cccaccgtga agatggcgtg gcactgagag gcagccattc tctcctgcca
     1981 aaccaggttc cggttccaca gcttccagtc cagtctgcaa cttcccctga cttgaaccca
     2041 ccccaagacc cttacagagg gatgccacca ggcctccagg gacagagtgt gtcttccggc
     2101 agctctgaga tcaagtccga cgacgagggc gatgagaacc tacaggacac aaaatcttcc
     2161 gaggacaaga aactagacga cgacaagaag gatatcaaat caattactag gtcaagatct
     2221 agcaataacg atgatgagga cctgaccccg gagcagaagg ccgagcgtga gaaggagcgg
     2281 aggatggcca ataacgcccg tgagcgcctg agggtccgtg atatcaacga ggctttcaag
     2341 gagctgggcc gcatggtaca gctccacctg aagagcgaca agccccagac caagctcctg
     2401 attctccacc aggcagtggc tgtcatcctc agcctggagc agcaagtgcg agaaaggaac
     2461 ctgaacccaa aagctgcctg tctgaaaaga agggaggaag agaaggtgtc ctcagagcct
     2521 cccccgctct ccttggctgg cccacaccct gggatgggag acgcagcgaa tcacatgggt
     2581 cagatgtgaa agggtccaag ttgccacctt gcttcattaa aacaagagac cacttcctta
     2641 acagctgtat tatcctaaac ccacataaac actgctcctt aaccccgttt tttttgtaat
     2701 ataagacaag tctgagtagt tatgaatcgc agacgcaaga ggtttcagca ttcccaatta
     2761 tcaaaaaaca gaaaaacaaa cacaaaaaaa aaatgaatga aagaaagaaa gaaagagaaa
     2821 atgcaacttg agggacgact tctttaacat atcactctga atgtgcgaag cggtatgtac
     2881 aggctgagac gcagcccaga gactgaatgg caatccttcc acactgtgga gcaatgcatt
     2941 tgtgcctaaa cttcttttgg aaaaaaaaat ataattaatt tgtaagtctg aaaaaaaata
     3001 tttaatttaa aaaaaattgt aaacttgcaa taatgaaaaa gtgtacttct gaagaaaaac
     3061 gacatgaacg tttttgttgg tattcaagtc agctagtgtt tctaattacc ggatattgaa
     3121 tagaggaagc ccggctaccc tcataacaaa accagcaacc gtcctgatgg caaccgaaat
     3181 gatgacatta gccattcctt agggtaggag ggacagatgg atgttataga cctatgacaa
     3241 atatatatat aaatatatat ataaatatat attaaaaatt tagtgactat ggtaagcttt
     3301 tgttcatttg tttcagactt ttttctcctg taaaaaaata gtactgatta acttttttaa
     3361 aagaaagatt ttactgtaaa tatggatttt tttttgtctg atttttgtcc cttcccccag
     3421 tttgttatcg tgacctgtag tgccaactct gcttccggag gggcagtgca ggacgaaatg
     3481 ctgaccctga tgttgcttct cattcataaa tagtagaaag ttgtttctcc agtcttttgg
     3541 gaacacagga cttaaaagtc acatcatgtg tagaaattac atgcagcatt gcccgggcaa
     3601 ggcaaaaaga gtttgtctgg cttgtggcac tgtgcttgtt accctctcct gggattttca
     3661 gaggtacacg gttagaatgc tacaatgtta ccactgtgcc ttccaatgtt tatatcatcg
     3721 gaaacatgac ataatcaaag tggctgtgat ttaacaaaaa aaaaaaaaga ttcaagtgtt
     3781 acctacctgt gtagcggaag tagtgtgcag tgagacgttt ctgaatacat ggtcagattt
     3841 tttttggaaa aaatacaaaa acaaaaaaaa aaaacaaaaa aatttaaaaa aaaaagtcaa
     3901 gttcaaaaac cgtcaaatga gaaaatcgca aggagtgtga cagctgattg attttgttgc
     3961 ttttcttgat tttttttttt ttgtttccaa atgggtttac taaaaagtac atgacttacc
     4021 tgcctcctcc ttcgtctgaa aacaaaaaac aaaaaaacaa tgccaaccta tcccacagca
     4081 ttatagcaag ccttataagc cctaaagcat taagttgcac tttggtgagg aggggtagcg
     4141 cagtattctc tctggccagt atgagtgaag tttatactta acatttgata gaaacataga
     4201 tcaaactgtg gcacagtaac tcatcagata gctagcgttg actctgggca caattgaacc
     4261 aattcccatc ctaaatcttt ccaacaattg actttggtgt acagtgcagt gaacacatag
     4321 aactcctact taagtattcg tcagcatcct tttgtctcta actcggttct gttttgacag
     4381 ccacacaatc ttggcatgta ttaagtaaaa aaaaaaaaaa aatccctgtt gaagtagttt
     4441 tcccacctat cagcactgag taattgccgt aactcaatgg aaatggtcta aacgcccccc
     4501 atctcttgtc ctgtaccacc agttacacag tgacaaaaca catctgtaaa ttttatgcaa
     4561 ccaatggcaa acctatcatt attttgaaac tgtgtatgta aaagttatat ttttacatgt
     4621 agactcttgt tattatgtgt tttaatacat tgtatcagtt ttttgtttcc tttttttttt
     4681 aactgtgtgg ttttaaaaag tcatttaaat gaaatagcga gctacaagaa tctgaaattt
     4741 atgttcattt ctgaaaatgt aagaacaaat aagatagtta tcacgtggtc accttttaca
     4801 aacccatcga tgttttgact agctgtgtgt atgtgtgtgt gtgcgcatgt gtgcgtgtgt
     4861 gtgtatgtgt gttgaaaact gtaaatatgt tcagtagcga taaaacgaca atgctttgat
     4921 ttgttgagaa gttcctaaaa tgtggaggtg gattgaaaat gtaggggaat agcagaaatc
     4981 agatttcatg aagagctctt ctcttcgggg gctttcctgt ggaatggtca aacagaggtg
     5041 ctccaagaag ggcaaggaag acagtaactt cccctcctcc ctgaacgacg gaaaccatgt
     5101 gtacgtggtc tctcaccatg ttaaagattt tctttccgtg atacattctg cactcttttt
     5161 gtatagtcta ccaaggcggg tatccctggg aacaatatta tgatatagga agcagtatac
     5221 tctgatcaca ttcaggagaa ttgtatagaa gagaatatgg tgtttactct ttagggaact
     5281 ggaaattctc cctgcattga tgtacatctt cagagcggcc cttttgatac acgttatcat
     5341 aaaggtgctg actaaagcag aattaaagtt tttcaaatct gtaaacaaag caaaaaatta
     5401 aattacagtc attcgattgt ttgttttttt ttttttccaa ttggtgcttt tatattttgt
     5461 tctcactcag acagaaaagg ctgcaatttc ttgttcacca gctttgatgt attcattact
     5521 cggtaatgta atacggctat tgtcaaattc cttttggaaa taagcaaaag gcttccccaa
     5581 ggcctgcagc agctgctggc tactttctgc ttggcgcaga aacatgatct gaccctctct
     5641 gtagtaatcg agttgtatct ccagttttaa aaagaaggaa aaagggaatg tggccgtttt
     5701 aatgtgtttt tttttttctt ttcttgttgt tattttgtaa ttctcaaacc caggtaagat
     5761 attggtattc ctgcactgga tttttgaaag aaacttagca gaagacagga tcgagatact
     5821 atagaagcat ttcccaagtg ttcatactat actagacata aatgataacg gcgatgtata
     5881 ggttcaggat cggtttaaga gactcagact ttgaaagcaa cttggaacgg ttgatccacc
     5941 tccacattcg agtaattaat aattctgcag aattagggat ctgtccatct aggagttgtt
     6001 acccatttgt cttctgtgtg gctgcgagga acactaacgc ttttacaact gtcagttcac
     6061 ccagtggtac aactgattct gactcagtct tccgattcct gttttgtatt ttgtttttcc
     6121 acttttttcc tatctcttga ttttattgtt gttgttattg ctattgttat tattattatt
     6181 cgtgatcttt atttcgatga ggggttggga agtgggaggg agtcgaactg agactagggg
     6241 ttgagaggat ttttttggtt tggttttctt ttcttttttt tttgtttttt tttttttttg
     6301 tttgtttgtt tcatctttgc gtccaacagg cagaatatgg tctgtgtcca aaacggaact
     6361 taagtcagga aggaaaccat tcagcgtaaa caagcacaac atgtagtctg tcggctgtct
     6421 ggaagcaaaa ataaattaat aaataaataa taaataagta aaagacacac acggaggtga
     6481 agatgaaatg tgatggattc cgagacaatg gggcaccaag gcctgtaggc ctcctcttga
     6541 ttttgctttg gttatgtttg ttttccttag agatgttttt ttcctcacgg gacttgaagt
     6601 gactcatctc tgtgcagtaa tggtttcgcc atatgctcat ttcaagtatt atagacatat
     6661 gtaatggtga aatatatgaa ctgtggcctt tttcattctt gttatttgtg atgcaattaa
     6721 gtgaagagaa gaaaaaaaaa agcagagatt taccatgtat cagtgcctgg ctttttgtta
     6781 taaagcttcg tctgtctagt gctctttttg ctataaaaat agactgtagt acaccctagt
     6841 aggaaaaaaa aaccctaaat ttaaaaataa aaaaatatat ttggcttatt tttcgcagga
     6901 gcaatccttt tataccatgg atattacaaa aaaaaaaatt gtcagattct gaatatttct
     6961 tctttgtaga tttttggaat cattataagt aaaagtttgt tactttattt tactatttaa
     7021 aagatgttat tttgccatgt gttactgaga tgaaactgta tggtatagct tcttctgttc
     7081 gttttttgtt tccggttttt tgtttgttcg tttttggttt tttttttttt tgtttgtttg
     7141 ttttgttttg tttttttttc ttagttgtag gtcgcagtaa ggacttttcc ttttgttttt
     7201 gttttttcgt tatgttttgt tttgtttttg cgactgtaca catagctgca gcattaaaaa
     7261 cttttaaaaa aatctgttaa aaaaaaaaga aaaaaaaggg aaaacgttta aaaaaaaaag
     7321 ataaacagtt acaccttgtt ttcaacgtgt ggctgagtgc ctcgattttt tcatgttttt
     7381 ggtgtatttc tgatttgtag aagtgtccaa acaggttgtg tcctggactt ccttcaagag
     7441 gcgaacaacc cagcttggtc taggccatga cctgttccca tctgtagtta ctcgatgaag
     7501 tcatgtacat gaccgttctg tagcaataaa tgtgccattt ttataaa
//
LOCUS       NM_001012047            2132 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 14, mRNA.
ACCESSION   NM_001012047 XM_039094457 XM_224619
VERSION     NM_001012047.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 26, 2025 this sequence version replaced
            XM_039094457.2, NM_001012047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1506989.1,
                                           SRR26360190.3006068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-248             JAXUCZ010000016.1  6871919-6872020
            249-507             JAXUCZ010000016.1  6894275-6894533
            508-657             JAXUCZ010000016.1  6898222-6898371
            658-2132            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2132
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    160..162
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            249..507
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1830
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 14; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001012047.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     265..339
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     340..1827
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    370..1281
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    370..1281
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(532..534,832..834,844..846,850..852,931..936,
                     940..945,1009..1011)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(532..534,832..834,844..846,850..852,931..936,
                     940..945,1009..1011)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(532..534,832..834,931..933)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(532..534,832..834,931..933)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    646..648
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    805..807
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(835..849,868..876,934..936,940..954,961..966,
                     1027..1032,1036..1044,1048..1053,1123..1128,1267..1281)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(835..849,868..876,934..936,940..954,961..966,
                     1027..1032,1036..1044,1048..1053,1123..1128,1267..1281)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1375..1824
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1375..1824
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1402..1404
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            508..657
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            658..2132
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaccc atgcttaact agatttctca tgcagcccag
      181 gccctccagc actggttaat agtcatcttc attcgtccct cgaagacgtg cccacagacc
      241 agcccaacat ttacggtctg cattatgtct ggagcccgca ctgcgcatgc gctcgtcttc
      301 ctcctcggct gttctgcgct tgcgttgggc gtctgctcag cctccctgga gcacggcgag
      361 gctgagtact acgtggctgc cgtgtacgaa caccgatcgg tcctgagccc aaaccccctg
      421 gagctcagca gccgccagca ggccctggag ctcatgaagc agaacctcga cgtctatgaa
      481 cagcaagtga tggctgcagc ccagaagggt gcgcacatta tagtgttccc agaagacggt
      541 atccacggat tcaacttcac aagaacatcc atttacccat tcttggactt gatgccatct
      601 cccaggctgg tcagttggaa cccgtgtctg gagccctttc gcttcaatga cacggaggtc
      661 ctccagcgcc tgagttgcat ggccatcaag ggaaagatgt tcttggtggc caatcttggg
      721 acaaaacagc cttgcctcgg cagcgaccct gggtgcccgc aggacgggag ataccagttt
      781 aacacaaacg tcgcgttcag tgacaacgga accctcgtcg gccgctaccg taagcacaac
      841 ctgtactttg aggaagcctt cgatagccct gctgacgtgg acctcaccac ctttgatacg
      901 ccgttcgcgg gcaagttcgg tatgttcact tgctttgata tcctgttctt tgaccccgcg
      961 gtccggctcc tcagagactt tgaggtaaag cacattgcgt accctacggc ctggatgaac
     1021 cagctgccgc tcttggcagc cattgaaatc cagaaagcat tcgccaccgc cttcggcgtc
     1081 accgttctgg cagctaacat ccaccacccg actctgggga tgacgggcag tggcatacac
     1141 acccctctga agtccttttg gtaccataac atggacgacc ccgaaggtca ccttataatt
     1201 gcccgggtag ccacaaaccc acagggcctc gttgggacag agaatacaac tagtgaaatg
     1261 gatccgtccc ataggaagtt cttaaaagtc ttgtctgggg atccgtactg tgagaaggat
     1321 gcccaggaag tgcgctgcga cgaggctgcc aagtggaacc tgaacgcacc acctaccttc
     1381 cactcggaga tgatgtatga caatttcacc ctggtccccg tctggggaaa ggaaggccac
     1441 ctccaggtgt gctccaacag tctctgttgc cacttacttt tcgagaggcc cgccctgtcc
     1501 aaagagctat atgccctggg tgtctttgac ggactccaca cagtgcacgg tacctactac
     1561 gttcaagcct gtgccctggt caagtgcggg ggcgctggct ttgaaacctg cgggcaggag
     1621 atctcggagg ccgagggctt gtttgacttt catctgtggg ggaacttcag caccttgtat
     1681 gtcttccctt tatttctcac ctcggggatg accctagaca cccctgacca gctcgggtgg
     1741 gagagcgacc actatttctt gaggaagagg ggactgtcct ccggcctggt gacggcagct
     1801 ctctatgggc ggttgtatga gaggaattag gaaaactgtg gtcagcaggt tgggctctgc
     1861 aggctggcct tgccttccca cggcccacag atcccaaaca ctgggaaaac cgccccgccc
     1921 ctgtggcact ggatcccacc ctggggaact gtaagaagat gggagaggca gttcctcctt
     1981 cctttctaca taatgactga gatattttct ggtattttct attcacatta ttctttttca
     2041 agccacaccc tcttaccact actacacaat tggttttaaa gactaagcca aaaaaaaaaa
     2101 aaaaaaataa acatcagctg ccattctaca aa
//
LOCUS       NM_001437015            2148 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 1, mRNA.
ACCESSION   NM_001437015 XM_006252619
VERSION     NM_001437015.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252619.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.163488.1,
                                           SRR26643287.32219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-219             JAXUCZ010000016.1  6871948-6872020
            220-264             JAXUCZ010000016.1  6893598-6893642
            265-523             JAXUCZ010000016.1  6894275-6894533
            524-673             JAXUCZ010000016.1  6898222-6898371
            674-2148            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2148
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..219
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            220..264
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1846
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_001423944.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MRRIFFPKRFTVCIMSGARTAHALVFLLGCSALALGVCSASLEH
                     GEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVF
                     PEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMF
                     LVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPAD
                     VDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEI
                     QKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQ
                     GLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY
                     DNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQAC
                     ALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWES
                     DHYFLRKRGLSSGLVTAALYGRLYERN"
     sig_peptide     239..349
                     /gene="Btd"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    386..1297
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    386..1297
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(548..550,848..850,860..862,866..868,947..952,
                     956..961,1025..1027)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(548..550,848..850,860..862,866..868,947..952,
                     956..961,1025..1027)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(548..550,848..850,947..949)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(548..550,848..850,947..949)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(851..865,884..892,950..952,956..970,977..982,
                     1043..1048,1052..1060,1064..1069,1139..1144,1283..1297)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(851..865,884..892,950..952,956..970,977..982,
                     1043..1048,1052..1060,1064..1069,1139..1144,1283..1297)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1391..1840
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1391..1840
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            265..523
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            524..673
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            674..2148
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagccca ggccctccag cactggttaa tagtcatctt
      181 cattcgtccc tcgaagacgt gcccacagac cagcccaaca aaatcccatg ttaccactat
      241 gagaaggatt ttctttccaa agcgatttac ggtctgcatt atgtctggag cccgcactgc
      301 gcatgcgctc gtcttcctcc tcggctgttc tgcgcttgcg ttgggcgtct gctcagcctc
      361 cctggagcac ggcgaggctg agtactacgt ggctgccgtg tacgaacacc gatcggtcct
      421 gagcccaaac cccctggagc tcagcagccg ccagcaggcc ctggagctca tgaagcagaa
      481 cctcgacgtc tatgaacagc aagtgatggc tgcagcccag aagggtgcgc acattatagt
      541 gttcccagaa gacggtatcc acggattcaa cttcacaaga acatccattt acccattctt
      601 ggacttgatg ccatctccca ggctggtcag ttggaacccg tgtctggagc cctttcgctt
      661 caatgacacg gaggtcctcc agcgcctgag ttgcatggcc atcaagggaa agatgttctt
      721 ggtggccaat cttgggacaa aacagccttg cctcggcagc gaccctgggt gcccgcagga
      781 cgggagatac cagtttaaca caaacgtcgc gttcagtgac aacggaaccc tcgtcggccg
      841 ctaccgtaag cacaacctgt actttgagga agccttcgat agccctgctg acgtggacct
      901 caccaccttt gatacgccgt tcgcgggcaa gttcggtatg ttcacttgct ttgatatcct
      961 gttctttgac cccgcggtcc ggctcctcag agactttgag gtaaagcaca ttgcgtaccc
     1021 tacggcctgg atgaaccagc tgccgctctt ggcagccatt gaaatccaga aagcattcgc
     1081 caccgccttc ggcgtcaccg ttctggcagc taacatccac cacccgactc tggggatgac
     1141 gggcagtggc atacacaccc ctctgaagtc cttttggtac cataacatgg acgaccccga
     1201 aggtcacctt ataattgccc gggtagccac aaacccacag ggcctcgttg ggacagagaa
     1261 tacaactagt gaaatggatc cgtcccatag gaagttctta aaagtcttgt ctggggatcc
     1321 gtactgtgag aaggatgccc aggaagtgcg ctgcgacgag gctgccaagt ggaacctgaa
     1381 cgcaccacct accttccact cggagatgat gtatgacaat ttcaccctgg tccccgtctg
     1441 gggaaaggaa ggccacctcc aggtgtgctc caacagtctc tgttgccact tacttttcga
     1501 gaggcccgcc ctgtccaaag agctatatgc cctgggtgtc tttgacggac tccacacagt
     1561 gcacggtacc tactacgttc aagcctgtgc cctggtcaag tgcgggggcg ctggctttga
     1621 aacctgcggg caggagatct cggaggccga gggcttgttt gactttcatc tgtgggggaa
     1681 cttcagcacc ttgtatgtct tccctttatt tctcacctcg gggatgaccc tagacacccc
     1741 tgaccagctc gggtgggaga gcgaccacta tttcttgagg aagaggggac tgtcctccgg
     1801 cctggtgacg gcagctctct atgggcggtt gtatgagagg aattaggaaa actgtggtca
     1861 gcaggttggg ctctgcaggc tggccttgcc ttcccacggc ccacagatcc caaacactgg
     1921 gaaaaccgcc ccgcccctgt ggcactggat cccaccctgg ggaactgtaa gaagatggga
     1981 gaggcagttc ctccttcctt tctacataat gactgagata ttttctggta ttttctattc
     2041 acattattct ttttcaagcc acaccctctt accactacta cacaattggt tttaaagact
     2101 aagccaaaaa aaaaaaaaaa aaataaacat cagctgccat tctacaaa
//
LOCUS       NM_001437023            2314 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 9, mRNA.
ACCESSION   NM_001437023 XM_006252615
VERSION     NM_001437023.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2314)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006252615.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.51995.1,
                                           SRR26643290.47338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-430              JAXUCZ010000016.1  6893598-6893959
            431-689             JAXUCZ010000016.1  6894275-6894533
            690-839             JAXUCZ010000016.1  6898222-6898371
            840-2314            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2314
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..430
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    324..326
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            431..689
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..2012
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 9; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423952.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     447..521
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     522..2009
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    552..1463
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    552..1463
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(714..716,1014..1016,1026..1028,1032..1034,
                     1113..1118,1122..1127,1191..1193)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(714..716,1014..1016,1026..1028,1032..1034,
                     1113..1118,1122..1127,1191..1193)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(714..716,1014..1016,1113..1115)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(714..716,1014..1016,1113..1115)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    828..830
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    987..989
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(1017..1031,1050..1058,1116..1118,1122..1136,
                     1143..1148,1209..1214,1218..1226,1230..1235,1305..1310,
                     1449..1463)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(1017..1031,1050..1058,1116..1118,1122..1136,
                     1143..1148,1209..1214,1218..1226,1230..1235,1305..1310,
                     1449..1463)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1557..2006
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1557..2006
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1584..1586
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            690..839
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            840..2314
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagaa aatcccatgt taccactatg agaaggattt tctttccaaa gcggtacgtc
      121 cttaagcaag tgattcggag tagcagacaa agcagaaaac agtgaaagcc gtgtgcggga
      181 ctctgacagg gagacttctt tatggctgcc ctgtgggtga cacagcagat gctagaattc
      241 caaaccgccc caaataaaaa ctgaagaata tcggctagga agctgccctg cgttcgggag
      301 cctcaggacc atcgcggctg tcctagaggg ctgacctgca atgctatgta tgtaagaaga
      361 ctcgagcaaa gcatcatcaa atatatcgca gaattgtgtc caaatttcag cccagttcct
      421 gcggcgcagg atttacggtc tgcattatgt ctggagcccg cactgcgcat gcgctcgtct
      481 tcctcctcgg ctgttctgcg cttgcgttgg gcgtctgctc agcctccctg gagcacggcg
      541 aggctgagta ctacgtggct gccgtgtacg aacaccgatc ggtcctgagc ccaaaccccc
      601 tggagctcag cagccgccag caggccctgg agctcatgaa gcagaacctc gacgtctatg
      661 aacagcaagt gatggctgca gcccagaagg gtgcgcacat tatagtgttc ccagaagacg
      721 gtatccacgg attcaacttc acaagaacat ccatttaccc attcttggac ttgatgccat
      781 ctcccaggct ggtcagttgg aacccgtgtc tggagccctt tcgcttcaat gacacggagg
      841 tcctccagcg cctgagttgc atggccatca agggaaagat gttcttggtg gccaatcttg
      901 ggacaaaaca gccttgcctc ggcagcgacc ctgggtgccc gcaggacggg agataccagt
      961 ttaacacaaa cgtcgcgttc agtgacaacg gaaccctcgt cggccgctac cgtaagcaca
     1021 acctgtactt tgaggaagcc ttcgatagcc ctgctgacgt ggacctcacc acctttgata
     1081 cgccgttcgc gggcaagttc ggtatgttca cttgctttga tatcctgttc tttgaccccg
     1141 cggtccggct cctcagagac tttgaggtaa agcacattgc gtaccctacg gcctggatga
     1201 accagctgcc gctcttggca gccattgaaa tccagaaagc attcgccacc gccttcggcg
     1261 tcaccgttct ggcagctaac atccaccacc cgactctggg gatgacgggc agtggcatac
     1321 acacccctct gaagtccttt tggtaccata acatggacga ccccgaaggt caccttataa
     1381 ttgcccgggt agccacaaac ccacagggcc tcgttgggac agagaataca actagtgaaa
     1441 tggatccgtc ccataggaag ttcttaaaag tcttgtctgg ggatccgtac tgtgagaagg
     1501 atgcccagga agtgcgctgc gacgaggctg ccaagtggaa cctgaacgca ccacctacct
     1561 tccactcgga gatgatgtat gacaatttca ccctggtccc cgtctgggga aaggaaggcc
     1621 acctccaggt gtgctccaac agtctctgtt gccacttact tttcgagagg cccgccctgt
     1681 ccaaagagct atatgccctg ggtgtctttg acggactcca cacagtgcac ggtacctact
     1741 acgttcaagc ctgtgccctg gtcaagtgcg ggggcgctgg ctttgaaacc tgcgggcagg
     1801 agatctcgga ggccgagggc ttgtttgact ttcatctgtg ggggaacttc agcaccttgt
     1861 atgtcttccc tttatttctc acctcgggga tgaccctaga cacccctgac cagctcgggt
     1921 gggagagcga ccactatttc ttgaggaaga ggggactgtc ctccggcctg gtgacggcag
     1981 ctctctatgg gcggttgtat gagaggaatt aggaaaactg tggtcagcag gttgggctct
     2041 gcaggctggc cttgccttcc cacggcccac agatcccaaa cactgggaaa accgccccgc
     2101 ccctgtggca ctggatccca ccctggggaa ctgtaagaag atgggagagg cagttcctcc
     2161 ttcctttcta cataatgact gagatatttt ctggtatttt ctattcacat tattcttttt
     2221 caagccacac cctcttacca ctactacaca attggtttta aagactaagc caaaaaaaaa
     2281 aaaaaaaaat aaacatcagc tgccattcta caaa
//
LOCUS       NM_001437083            6594 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            13, mRNA.
ACCESSION   NM_001437083 XM_039097186
VERSION     NM_001437083.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6594)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6594)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6594)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6594)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6594)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6594)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6594)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6594)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6594)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6594)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097186.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54618.1,
                                           SRR26643298.74603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-766             JAXUCZ010000018.1  65528841-65528917
            767-970             JAXUCZ010000018.1  65531547-65531750
            971-1106            JAXUCZ010000018.1  65551334-65551469
            1107-1269           JAXUCZ010000018.1  65553405-65553567
            1270-1499           JAXUCZ010000018.1  65556812-65557041
            1500-1640           JAXUCZ010000018.1  65557878-65558018
            1641-6594           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6594
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1636
                     /gene="Tcf4"
                     /note="isoform 13 is encoded by transcript variant 13;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 13"
                     /protein_id="NP_001424012.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPL
                     HSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGY
                     GTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYR
                     GMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNND
                     DEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLIL
                     HQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMG
                     QM"
     misc_feature    1304..1558
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1304..1558
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1328..1330,1340..1342,1346..1354,1358..1360,
                     1373..1375,1436..1441)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1328..1330,1340..1342,1346..1354,1358..1360,
                     1373..1375,1436..1441)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1367..1372,1379..1384,1388..1393,1400..1402,
                     1412..1414,1442..1444,1451..1453,1463..1465,1472..1474,
                     1481..1498)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1367..1372,1379..1384,1388..1393,1400..1402,
                     1412..1414,1442..1444,1451..1453,1463..1465,1472..1474,
                     1481..1498)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..766
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..970
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1106
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1269
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1499
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1640
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..6594
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagc aggcacagct gtttggtctc gaaacggagg
      721 acaggcctcg tcatctccca attacgaagg acccttgcac tccttgcaga gccgaattga
      781 agaccgttta gaaagactgg acgacgcgat tcatgttctc cggaaccacg cggtgggccc
      841 atccacagct gtgcccggtg gccatgggga catgcatggg atcatcggac cctctcacaa
      901 tggagcaatg ggcagtctgg gctcaggata tggaactggc cttctctcag ccaacagaca
      961 ttcactcatg gtcggggccc accgtgaaga tggcgtggca ctgagaggca gccattctct
     1021 cctgccaaac caggttccgg ttccacagct tccagtccag tctgcaactt cccctgactt
     1081 gaacccaccc caagaccctt acagagggat gccaccaggc ctccagggac agagtgtgtc
     1141 ttccggcagc tctgagatca agtccgacga cgagggcgat gagaacctac aggacacaaa
     1201 atcttccgag gacaagaaac tagacgacga caagaaggat atcaaatcaa ttactaggtc
     1261 aagatctagc aataacgatg atgaggacct gaccccggag cagaaggccg agcgtgagaa
     1321 ggagcggagg atggccaata acgcccgtga gcgcctgagg gtccgtgata tcaacgaggc
     1381 tttcaaggag ctgggccgca tggtacagct ccacctgaag agcgacaagc cccagaccaa
     1441 gctcctgatt ctccaccagg cagtggctgt catcctcagc ctggagcagc aagtgcgaga
     1501 aaggaacctg aacccaaaag ctgcctgtct gaaaagaagg gaggaagaga aggtgtcctc
     1561 agagcctccc ccgctctcct tggctggccc acaccctggg atgggagacg cagcgaatca
     1621 catgggtcag atgtgaaagg gtccaagttg ccaccttgct tcattaaaac aagagaccac
     1681 ttccttaaca gctgtattat cctaaaccca cataaacact gctccttaac cccgtttttt
     1741 ttgtaatata agacaagtct gagtagttat gaatcgcaga cgcaagaggt ttcagcattc
     1801 ccaattatca aaaaacagaa aaacaaacac aaaaaaaaaa tgaatgaaag aaagaaagaa
     1861 agagaaaatg caacttgagg gacgacttct ttaacatatc actctgaatg tgcgaagcgg
     1921 tatgtacagg ctgagacgca gcccagagac tgaatggcaa tccttccaca ctgtggagca
     1981 atgcatttgt gcctaaactt cttttggaaa aaaaaatata attaatttgt aagtctgaaa
     2041 aaaaatattt aatttaaaaa aaattgtaaa cttgcaataa tgaaaaagtg tacttctgaa
     2101 gaaaaacgac atgaacgttt ttgttggtat tcaagtcagc tagtgtttct aattaccgga
     2161 tattgaatag aggaagcccg gctaccctca taacaaaacc agcaaccgtc ctgatggcaa
     2221 ccgaaatgat gacattagcc attccttagg gtaggaggga cagatggatg ttatagacct
     2281 atgacaaata tatatataaa tatatatata aatatatatt aaaaatttag tgactatggt
     2341 aagcttttgt tcatttgttt cagacttttt tctcctgtaa aaaaatagta ctgattaact
     2401 tttttaaaag aaagatttta ctgtaaatat ggattttttt ttgtctgatt tttgtccctt
     2461 cccccagttt gttatcgtga cctgtagtgc caactctgct tccggagggg cagtgcagga
     2521 cgaaatgctg accctgatgt tgcttctcat tcataaatag tagaaagttg tttctccagt
     2581 cttttgggaa cacaggactt aaaagtcaca tcatgtgtag aaattacatg cagcattgcc
     2641 cgggcaaggc aaaaagagtt tgtctggctt gtggcactgt gcttgttacc ctctcctggg
     2701 attttcagag gtacacggtt agaatgctac aatgttacca ctgtgccttc caatgtttat
     2761 atcatcggaa acatgacata atcaaagtgg ctgtgattta acaaaaaaaa aaaaagattc
     2821 aagtgttacc tacctgtgta gcggaagtag tgtgcagtga gacgtttctg aatacatggt
     2881 cagatttttt ttggaaaaaa tacaaaaaca aaaaaaaaaa acaaaaaaat ttaaaaaaaa
     2941 aagtcaagtt caaaaaccgt caaatgagaa aatcgcaagg agtgtgacag ctgattgatt
     3001 ttgttgcttt tcttgatttt tttttttttg tttccaaatg ggtttactaa aaagtacatg
     3061 acttacctgc ctcctccttc gtctgaaaac aaaaaacaaa aaaacaatgc caacctatcc
     3121 cacagcatta tagcaagcct tataagccct aaagcattaa gttgcacttt ggtgaggagg
     3181 ggtagcgcag tattctctct ggccagtatg agtgaagttt atacttaaca tttgatagaa
     3241 acatagatca aactgtggca cagtaactca tcagatagct agcgttgact ctgggcacaa
     3301 ttgaaccaat tcccatccta aatctttcca acaattgact ttggtgtaca gtgcagtgaa
     3361 cacatagaac tcctacttaa gtattcgtca gcatcctttt gtctctaact cggttctgtt
     3421 ttgacagcca cacaatcttg gcatgtatta agtaaaaaaa aaaaaaaaat ccctgttgaa
     3481 gtagttttcc cacctatcag cactgagtaa ttgccgtaac tcaatggaaa tggtctaaac
     3541 gccccccatc tcttgtcctg taccaccagt tacacagtga caaaacacat ctgtaaattt
     3601 tatgcaacca atggcaaacc tatcattatt ttgaaactgt gtatgtaaaa gttatatttt
     3661 tacatgtaga ctcttgttat tatgtgtttt aatacattgt atcagttttt tgtttccttt
     3721 tttttttaac tgtgtggttt taaaaagtca tttaaatgaa atagcgagct acaagaatct
     3781 gaaatttatg ttcatttctg aaaatgtaag aacaaataag atagttatca cgtggtcacc
     3841 ttttacaaac ccatcgatgt tttgactagc tgtgtgtatg tgtgtgtgtg cgcatgtgtg
     3901 cgtgtgtgtg tatgtgtgtt gaaaactgta aatatgttca gtagcgataa aacgacaatg
     3961 ctttgatttg ttgagaagtt cctaaaatgt ggaggtggat tgaaaatgta ggggaatagc
     4021 agaaatcaga tttcatgaag agctcttctc ttcgggggct ttcctgtgga atggtcaaac
     4081 agaggtgctc caagaagggc aaggaagaca gtaacttccc ctcctccctg aacgacggaa
     4141 accatgtgta cgtggtctct caccatgtta aagattttct ttccgtgata cattctgcac
     4201 tctttttgta tagtctacca aggcgggtat ccctgggaac aatattatga tataggaagc
     4261 agtatactct gatcacattc aggagaattg tatagaagag aatatggtgt ttactcttta
     4321 gggaactgga aattctccct gcattgatgt acatcttcag agcggccctt ttgatacacg
     4381 ttatcataaa ggtgctgact aaagcagaat taaagttttt caaatctgta aacaaagcaa
     4441 aaaattaaat tacagtcatt cgattgtttg tttttttttt tttccaattg gtgcttttat
     4501 attttgttct cactcagaca gaaaaggctg caatttcttg ttcaccagct ttgatgtatt
     4561 cattactcgg taatgtaata cggctattgt caaattcctt ttggaaataa gcaaaaggct
     4621 tccccaaggc ctgcagcagc tgctggctac tttctgcttg gcgcagaaac atgatctgac
     4681 cctctctgta gtaatcgagt tgtatctcca gttttaaaaa gaaggaaaaa gggaatgtgg
     4741 ccgttttaat gtgttttttt ttttcttttc ttgttgttat tttgtaattc tcaaacccag
     4801 gtaagatatt ggtattcctg cactggattt ttgaaagaaa cttagcagaa gacaggatcg
     4861 agatactata gaagcatttc ccaagtgttc atactatact agacataaat gataacggcg
     4921 atgtataggt tcaggatcgg tttaagagac tcagactttg aaagcaactt ggaacggttg
     4981 atccacctcc acattcgagt aattaataat tctgcagaat tagggatctg tccatctagg
     5041 agttgttacc catttgtctt ctgtgtggct gcgaggaaca ctaacgcttt tacaactgtc
     5101 agttcaccca gtggtacaac tgattctgac tcagtcttcc gattcctgtt ttgtattttg
     5161 tttttccact tttttcctat ctcttgattt tattgttgtt gttattgcta ttgttattat
     5221 tattattcgt gatctttatt tcgatgaggg gttgggaagt gggagggagt cgaactgaga
     5281 ctaggggttg agaggatttt tttggtttgg ttttcttttc tttttttttt gttttttttt
     5341 ttttttgttt gtttgtttca tctttgcgtc caacaggcag aatatggtct gtgtccaaaa
     5401 cggaacttaa gtcaggaagg aaaccattca gcgtaaacaa gcacaacatg tagtctgtcg
     5461 gctgtctgga agcaaaaata aattaataaa taaataataa ataagtaaaa gacacacacg
     5521 gaggtgaaga tgaaatgtga tggattccga gacaatgggg caccaaggcc tgtaggcctc
     5581 ctcttgattt tgctttggtt atgtttgttt tccttagaga tgtttttttc ctcacgggac
     5641 ttgaagtgac tcatctctgt gcagtaatgg tttcgccata tgctcatttc aagtattata
     5701 gacatatgta atggtgaaat atatgaactg tggccttttt cattcttgtt atttgtgatg
     5761 caattaagtg aagagaagaa aaaaaaaagc agagatttac catgtatcag tgcctggctt
     5821 tttgttataa agcttcgtct gtctagtgct ctttttgcta taaaaataga ctgtagtaca
     5881 ccctagtagg aaaaaaaaac cctaaattta aaaataaaaa aatatatttg gcttattttt
     5941 cgcaggagca atccttttat accatggata ttacaaaaaa aaaaattgtc agattctgaa
     6001 tatttcttct ttgtagattt ttggaatcat tataagtaaa agtttgttac tttattttac
     6061 tatttaaaag atgttatttt gccatgtgtt actgagatga aactgtatgg tatagcttct
     6121 tctgttcgtt ttttgtttcc ggttttttgt ttgttcgttt ttggtttttt ttttttttgt
     6181 ttgtttgttt tgttttgttt ttttttctta gttgtaggtc gcagtaagga cttttccttt
     6241 tgtttttgtt ttttcgttat gttttgtttt gtttttgcga ctgtacacat agctgcagca
     6301 ttaaaaactt ttaaaaaaat ctgttaaaaa aaaaagaaaa aaaagggaaa acgtttaaaa
     6361 aaaaaagata aacagttaca ccttgttttc aacgtgtggc tgagtgcctc gattttttca
     6421 tgtttttggt gtatttctga tttgtagaag tgtccaaaca ggttgtgtcc tggacttcct
     6481 tcaagaggcg aacaacccag cttggtctag gccatgacct gttcccatct gtagttactc
     6541 gatgaagtca tgtacatgac cgttctgtag caataaatgt gccattttta taaa
//
LOCUS       NM_001437020            2190 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 6, mRNA.
ACCESSION   NM_001437020 XM_063275350
VERSION     NM_001437020.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2190)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063275350.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.49873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-219             JAXUCZ010000016.1  6871948-6872020
            220-261             JAXUCZ010000016.1  6890885-6890926
            262-306             JAXUCZ010000016.1  6893598-6893642
            307-565             JAXUCZ010000016.1  6894275-6894533
            566-715             JAXUCZ010000016.1  6898222-6898371
            716-2190            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2190
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..219
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            220..261
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    260..262
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            262..306
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1888
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 6; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_001423949.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MRRIFFPKRFTVCIMSGARTAHALVFLLGCSALALGVCSASLEH
                     GEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVF
                     PEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMF
                     LVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPAD
                     VDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEI
                     QKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQ
                     GLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY
                     DNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQAC
                     ALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWES
                     DHYFLRKRGLSSGLVTAALYGRLYERN"
     sig_peptide     281..391
                     /gene="Btd"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    428..1339
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    428..1339
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(590..592,890..892,902..904,908..910,989..994,
                     998..1003,1067..1069)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(590..592,890..892,902..904,908..910,989..994,
                     998..1003,1067..1069)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(590..592,890..892,989..991)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(590..592,890..892,989..991)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(893..907,926..934,992..994,998..1012,1019..1024,
                     1085..1090,1094..1102,1106..1111,1181..1186,1325..1339)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(893..907,926..934,992..994,998..1012,1019..1024,
                     1085..1090,1094..1102,1106..1111,1181..1186,1325..1339)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1433..1882
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1433..1882
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            307..565
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            566..715
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            716..2190
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagccca ggccctccag cactggttaa tagtcatctt
      181 cattcgtccc tcgaagacgt gcccacagac cagcccaaca ctcttactgg accttgggtc
      241 agtggtgaga ctgattgact gaaaatccca tgttaccact atgagaagga ttttctttcc
      301 aaagcgattt acggtctgca ttatgtctgg agcccgcact gcgcatgcgc tcgtcttcct
      361 cctcggctgt tctgcgcttg cgttgggcgt ctgctcagcc tccctggagc acggcgaggc
      421 tgagtactac gtggctgccg tgtacgaaca ccgatcggtc ctgagcccaa accccctgga
      481 gctcagcagc cgccagcagg ccctggagct catgaagcag aacctcgacg tctatgaaca
      541 gcaagtgatg gctgcagccc agaagggtgc gcacattata gtgttcccag aagacggtat
      601 ccacggattc aacttcacaa gaacatccat ttacccattc ttggacttga tgccatctcc
      661 caggctggtc agttggaacc cgtgtctgga gccctttcgc ttcaatgaca cggaggtcct
      721 ccagcgcctg agttgcatgg ccatcaaggg aaagatgttc ttggtggcca atcttgggac
      781 aaaacagcct tgcctcggca gcgaccctgg gtgcccgcag gacgggagat accagtttaa
      841 cacaaacgtc gcgttcagtg acaacggaac cctcgtcggc cgctaccgta agcacaacct
      901 gtactttgag gaagccttcg atagccctgc tgacgtggac ctcaccacct ttgatacgcc
      961 gttcgcgggc aagttcggta tgttcacttg ctttgatatc ctgttctttg accccgcggt
     1021 ccggctcctc agagactttg aggtaaagca cattgcgtac cctacggcct ggatgaacca
     1081 gctgccgctc ttggcagcca ttgaaatcca gaaagcattc gccaccgcct tcggcgtcac
     1141 cgttctggca gctaacatcc accacccgac tctggggatg acgggcagtg gcatacacac
     1201 ccctctgaag tccttttggt accataacat ggacgacccc gaaggtcacc ttataattgc
     1261 ccgggtagcc acaaacccac agggcctcgt tgggacagag aatacaacta gtgaaatgga
     1321 tccgtcccat aggaagttct taaaagtctt gtctggggat ccgtactgtg agaaggatgc
     1381 ccaggaagtg cgctgcgacg aggctgccaa gtggaacctg aacgcaccac ctaccttcca
     1441 ctcggagatg atgtatgaca atttcaccct ggtccccgtc tggggaaagg aaggccacct
     1501 ccaggtgtgc tccaacagtc tctgttgcca cttacttttc gagaggcccg ccctgtccaa
     1561 agagctatat gccctgggtg tctttgacgg actccacaca gtgcacggta cctactacgt
     1621 tcaagcctgt gccctggtca agtgcggggg cgctggcttt gaaacctgcg ggcaggagat
     1681 ctcggaggcc gagggcttgt ttgactttca tctgtggggg aacttcagca ccttgtatgt
     1741 cttcccttta tttctcacct cggggatgac cctagacacc cctgaccagc tcgggtggga
     1801 gagcgaccac tatttcttga ggaagagggg actgtcctcc ggcctggtga cggcagctct
     1861 ctatgggcgg ttgtatgaga ggaattagga aaactgtggt cagcaggttg ggctctgcag
     1921 gctggccttg ccttcccacg gcccacagat cccaaacact gggaaaaccg ccccgcccct
     1981 gtggcactgg atcccaccct ggggaactgt aagaagatgg gagaggcagt tcctccttcc
     2041 tttctacata atgactgaga tattttctgg tattttctat tcacattatt ctttttcaag
     2101 ccacaccctc ttaccactac tacacaattg gttttaaaga ctaagccaaa aaaaaaaaaa
     2161 aaaaataaac atcagctgcc attctacaaa
//
LOCUS       NM_001437087            6591 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            15, mRNA.
ACCESSION   NM_001437087 XM_039097188
VERSION     NM_001437087.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6591)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6591)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6591)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6591)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6591)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6591)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6591)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6591)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6591)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6591)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097188.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1736198.1,
                                           SRR26360176.1170088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-763             JAXUCZ010000018.1  65528844-65528917
            764-967             JAXUCZ010000018.1  65531547-65531750
            968-1103            JAXUCZ010000018.1  65551334-65551469
            1104-1266           JAXUCZ010000018.1  65553405-65553567
            1267-1496           JAXUCZ010000018.1  65556812-65557041
            1497-1637           JAXUCZ010000018.1  65557878-65558018
            1638-6591           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6591
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1633
                     /gene="Tcf4"
                     /note="isoform 15 is encoded by transcript variant 15;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 15"
                     /protein_id="NP_001424016.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSGTAVWSRNGGQASSSPNYEGPLH
                     SLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYG
                     TGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRG
                     MPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDD
                     EDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILH
                     QAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQ
                     M"
     misc_feature    1301..1555
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1301..1555
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1325..1327,1337..1339,1343..1351,1355..1357,
                     1370..1372,1433..1438)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1325..1327,1337..1339,1343..1351,1355..1357,
                     1370..1372,1433..1438)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1364..1369,1376..1381,1385..1390,1397..1399,
                     1409..1411,1439..1441,1448..1450,1460..1462,1469..1471,
                     1478..1495)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1364..1369,1376..1381,1385..1390,1397..1399,
                     1409..1411,1439..1441,1448..1450,1460..1462,1469..1471,
                     1478..1495)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..763
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1266
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1496
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1637
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..6591
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagg cacagctgtt tggtctcgaa acggaggaca
      721 ggcctcgtca tctcccaatt acgaaggacc cttgcactcc ttgcagagcc gaattgaaga
      781 ccgtttagaa agactggacg acgcgattca tgttctccgg aaccacgcgg tgggcccatc
      841 cacagctgtg cccggtggcc atggggacat gcatgggatc atcggaccct ctcacaatgg
      901 agcaatgggc agtctgggct caggatatgg aactggcctt ctctcagcca acagacattc
      961 actcatggtc ggggcccacc gtgaagatgg cgtggcactg agaggcagcc attctctcct
     1021 gccaaaccag gttccggttc cacagcttcc agtccagtct gcaacttccc ctgacttgaa
     1081 cccaccccaa gacccttaca gagggatgcc accaggcctc cagggacaga gtgtgtcttc
     1141 cggcagctct gagatcaagt ccgacgacga gggcgatgag aacctacagg acacaaaatc
     1201 ttccgaggac aagaaactag acgacgacaa gaaggatatc aaatcaatta ctaggtcaag
     1261 atctagcaat aacgatgatg aggacctgac cccggagcag aaggccgagc gtgagaagga
     1321 gcggaggatg gccaataacg cccgtgagcg cctgagggtc cgtgatatca acgaggcttt
     1381 caaggagctg ggccgcatgg tacagctcca cctgaagagc gacaagcccc agaccaagct
     1441 cctgattctc caccaggcag tggctgtcat cctcagcctg gagcagcaag tgcgagaaag
     1501 gaacctgaac ccaaaagctg cctgtctgaa aagaagggag gaagagaagg tgtcctcaga
     1561 gcctcccccg ctctccttgg ctggcccaca ccctgggatg ggagacgcag cgaatcacat
     1621 gggtcagatg tgaaagggtc caagttgcca ccttgcttca ttaaaacaag agaccacttc
     1681 cttaacagct gtattatcct aaacccacat aaacactgct ccttaacccc gttttttttg
     1741 taatataaga caagtctgag tagttatgaa tcgcagacgc aagaggtttc agcattccca
     1801 attatcaaaa aacagaaaaa caaacacaaa aaaaaaatga atgaaagaaa gaaagaaaga
     1861 gaaaatgcaa cttgagggac gacttcttta acatatcact ctgaatgtgc gaagcggtat
     1921 gtacaggctg agacgcagcc cagagactga atggcaatcc ttccacactg tggagcaatg
     1981 catttgtgcc taaacttctt ttggaaaaaa aaatataatt aatttgtaag tctgaaaaaa
     2041 aatatttaat ttaaaaaaaa ttgtaaactt gcaataatga aaaagtgtac ttctgaagaa
     2101 aaacgacatg aacgtttttg ttggtattca agtcagctag tgtttctaat taccggatat
     2161 tgaatagagg aagcccggct accctcataa caaaaccagc aaccgtcctg atggcaaccg
     2221 aaatgatgac attagccatt ccttagggta ggagggacag atggatgtta tagacctatg
     2281 acaaatatat atataaatat atatataaat atatattaaa aatttagtga ctatggtaag
     2341 cttttgttca tttgtttcag acttttttct cctgtaaaaa aatagtactg attaactttt
     2401 ttaaaagaaa gattttactg taaatatgga tttttttttg tctgattttt gtcccttccc
     2461 ccagtttgtt atcgtgacct gtagtgccaa ctctgcttcc ggaggggcag tgcaggacga
     2521 aatgctgacc ctgatgttgc ttctcattca taaatagtag aaagttgttt ctccagtctt
     2581 ttgggaacac aggacttaaa agtcacatca tgtgtagaaa ttacatgcag cattgcccgg
     2641 gcaaggcaaa aagagtttgt ctggcttgtg gcactgtgct tgttaccctc tcctgggatt
     2701 ttcagaggta cacggttaga atgctacaat gttaccactg tgccttccaa tgtttatatc
     2761 atcggaaaca tgacataatc aaagtggctg tgatttaaca aaaaaaaaaa aagattcaag
     2821 tgttacctac ctgtgtagcg gaagtagtgt gcagtgagac gtttctgaat acatggtcag
     2881 attttttttg gaaaaaatac aaaaacaaaa aaaaaaaaca aaaaaattta aaaaaaaaag
     2941 tcaagttcaa aaaccgtcaa atgagaaaat cgcaaggagt gtgacagctg attgattttg
     3001 ttgcttttct tgattttttt ttttttgttt ccaaatgggt ttactaaaaa gtacatgact
     3061 tacctgcctc ctccttcgtc tgaaaacaaa aaacaaaaaa acaatgccaa cctatcccac
     3121 agcattatag caagccttat aagccctaaa gcattaagtt gcactttggt gaggaggggt
     3181 agcgcagtat tctctctggc cagtatgagt gaagtttata cttaacattt gatagaaaca
     3241 tagatcaaac tgtggcacag taactcatca gatagctagc gttgactctg ggcacaattg
     3301 aaccaattcc catcctaaat ctttccaaca attgactttg gtgtacagtg cagtgaacac
     3361 atagaactcc tacttaagta ttcgtcagca tccttttgtc tctaactcgg ttctgttttg
     3421 acagccacac aatcttggca tgtattaagt aaaaaaaaaa aaaaaatccc tgttgaagta
     3481 gttttcccac ctatcagcac tgagtaattg ccgtaactca atggaaatgg tctaaacgcc
     3541 ccccatctct tgtcctgtac caccagttac acagtgacaa aacacatctg taaattttat
     3601 gcaaccaatg gcaaacctat cattattttg aaactgtgta tgtaaaagtt atatttttac
     3661 atgtagactc ttgttattat gtgttttaat acattgtatc agttttttgt ttcctttttt
     3721 ttttaactgt gtggttttaa aaagtcattt aaatgaaata gcgagctaca agaatctgaa
     3781 atttatgttc atttctgaaa atgtaagaac aaataagata gttatcacgt ggtcaccttt
     3841 tacaaaccca tcgatgtttt gactagctgt gtgtatgtgt gtgtgtgcgc atgtgtgcgt
     3901 gtgtgtgtat gtgtgttgaa aactgtaaat atgttcagta gcgataaaac gacaatgctt
     3961 tgatttgttg agaagttcct aaaatgtgga ggtggattga aaatgtaggg gaatagcaga
     4021 aatcagattt catgaagagc tcttctcttc gggggctttc ctgtggaatg gtcaaacaga
     4081 ggtgctccaa gaagggcaag gaagacagta acttcccctc ctccctgaac gacggaaacc
     4141 atgtgtacgt ggtctctcac catgttaaag attttctttc cgtgatacat tctgcactct
     4201 ttttgtatag tctaccaagg cgggtatccc tgggaacaat attatgatat aggaagcagt
     4261 atactctgat cacattcagg agaattgtat agaagagaat atggtgttta ctctttaggg
     4321 aactggaaat tctccctgca ttgatgtaca tcttcagagc ggcccttttg atacacgtta
     4381 tcataaaggt gctgactaaa gcagaattaa agtttttcaa atctgtaaac aaagcaaaaa
     4441 attaaattac agtcattcga ttgtttgttt tttttttttt ccaattggtg cttttatatt
     4501 ttgttctcac tcagacagaa aaggctgcaa tttcttgttc accagctttg atgtattcat
     4561 tactcggtaa tgtaatacgg ctattgtcaa attccttttg gaaataagca aaaggcttcc
     4621 ccaaggcctg cagcagctgc tggctacttt ctgcttggcg cagaaacatg atctgaccct
     4681 ctctgtagta atcgagttgt atctccagtt ttaaaaagaa ggaaaaaggg aatgtggccg
     4741 ttttaatgtg tttttttttt tcttttcttg ttgttatttt gtaattctca aacccaggta
     4801 agatattggt attcctgcac tggatttttg aaagaaactt agcagaagac aggatcgaga
     4861 tactatagaa gcatttccca agtgttcata ctatactaga cataaatgat aacggcgatg
     4921 tataggttca ggatcggttt aagagactca gactttgaaa gcaacttgga acggttgatc
     4981 cacctccaca ttcgagtaat taataattct gcagaattag ggatctgtcc atctaggagt
     5041 tgttacccat ttgtcttctg tgtggctgcg aggaacacta acgcttttac aactgtcagt
     5101 tcacccagtg gtacaactga ttctgactca gtcttccgat tcctgttttg tattttgttt
     5161 ttccactttt ttcctatctc ttgattttat tgttgttgtt attgctattg ttattattat
     5221 tattcgtgat ctttatttcg atgaggggtt gggaagtggg agggagtcga actgagacta
     5281 ggggttgaga ggattttttt ggtttggttt tcttttcttt tttttttgtt tttttttttt
     5341 tttgtttgtt tgtttcatct ttgcgtccaa caggcagaat atggtctgtg tccaaaacgg
     5401 aacttaagtc aggaaggaaa ccattcagcg taaacaagca caacatgtag tctgtcggct
     5461 gtctggaagc aaaaataaat taataaataa ataataaata agtaaaagac acacacggag
     5521 gtgaagatga aatgtgatgg attccgagac aatggggcac caaggcctgt aggcctcctc
     5581 ttgattttgc tttggttatg tttgttttcc ttagagatgt ttttttcctc acgggacttg
     5641 aagtgactca tctctgtgca gtaatggttt cgccatatgc tcatttcaag tattatagac
     5701 atatgtaatg gtgaaatata tgaactgtgg cctttttcat tcttgttatt tgtgatgcaa
     5761 ttaagtgaag agaagaaaaa aaaaagcaga gatttaccat gtatcagtgc ctggcttttt
     5821 gttataaagc ttcgtctgtc tagtgctctt tttgctataa aaatagactg tagtacaccc
     5881 tagtaggaaa aaaaaaccct aaatttaaaa ataaaaaaat atatttggct tatttttcgc
     5941 aggagcaatc cttttatacc atggatatta caaaaaaaaa aattgtcaga ttctgaatat
     6001 ttcttctttg tagatttttg gaatcattat aagtaaaagt ttgttacttt attttactat
     6061 ttaaaagatg ttattttgcc atgtgttact gagatgaaac tgtatggtat agcttcttct
     6121 gttcgttttt tgtttccggt tttttgtttg ttcgtttttg gttttttttt tttttgtttg
     6181 tttgttttgt tttgtttttt tttcttagtt gtaggtcgca gtaaggactt ttccttttgt
     6241 ttttgttttt tcgttatgtt ttgttttgtt tttgcgactg tacacatagc tgcagcatta
     6301 aaaactttta aaaaaatctg ttaaaaaaaa aagaaaaaaa agggaaaacg tttaaaaaaa
     6361 aaagataaac agttacacct tgttttcaac gtgtggctga gtgcctcgat tttttcatgt
     6421 ttttggtgta tttctgattt gtagaagtgt ccaaacaggt tgtgtcctgg acttccttca
     6481 agaggcgaac aacccagctt ggtctaggcc atgacctgtt cccatctgta gttactcgat
     6541 gaagtcatgt acatgaccgt tctgtagcaa taaatgtgcc atttttataa a
//
LOCUS       NM_001437080            5312 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 7, mRNA.
ACCESSION   NM_001437080 XM_063288034
VERSION     NM_001437080.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5312)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5312)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5312)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5312)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5312)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5312)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5312)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5312)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5312)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288034.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1642106.1,
                                           SRR26360176.1182857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-651             JAXUCZ010000005.1  148171091-148171196
            652-830             JAXUCZ010000005.1  148172129-148172307
            831-997             JAXUCZ010000005.1  148181206-148181372
            998-1268            JAXUCZ010000005.1  148183570-148183840
            1269-1362           JAXUCZ010000005.1  148195258-148195351
            1363-1464           JAXUCZ010000005.1  148197680-148197781
            1465-1616           JAXUCZ010000005.1  148200975-148201126
            1617-1755           JAXUCZ010000005.1  148203568-148203706
            1756-1899           JAXUCZ010000005.1  148205552-148205695
            1900-2196           JAXUCZ010000005.1  148206678-148206974
            2197-2433           JAXUCZ010000005.1  148208059-148208295
            2434-2701           JAXUCZ010000005.1  148218465-148218732
            2702-2831           JAXUCZ010000005.1  148219783-148219912
            2832-2960           JAXUCZ010000005.1  148221617-148221745
            2961-3098           JAXUCZ010000005.1  148225153-148225290
            3099-3224           JAXUCZ010000005.1  148228732-148228857
            3225-3346           JAXUCZ010000005.1  148229514-148229635
            3347-3539           JAXUCZ010000005.1  148231206-148231398
            3540-5312           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5312
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3671
                     /gene="Pum1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 7"
                     /protein_id="NP_001424009.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGELLPGKKFWETDESSKD
                     GPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGV
                     SMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVMD
                     KTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPVE
                     DFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNA
                     LAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATL
                     GPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGAS
                     QRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVV
                     NAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGT
                     QQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLGA
                     TLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSSSP
                     GPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSAS
                     SASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFS
                     QDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQKL
                     ALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHV
                     VQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQ
                     HTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHA
                     SRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPH
                     IATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2637..3602
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2637..3602
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2805..2810,2817..2819,2913..2918,2925..2927,
                     3024..3026,3033..3035,3129..3134,3141..3143,3228..3233,
                     3237..3242,3249..3251,3336..3341,3345..3350,3357..3359,
                     3465..3470,3474..3479,3486..3488,3576..3578,3585..3587)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2805..2810,2817..2819,2913..2918,2925..2927,
                     3024..3026,3033..3035,3129..3134,3141..3143,3228..3233,
                     3237..3242,3249..3251,3336..3341,3345..3350,3357..3359,
                     3465..3470,3474..3479,3486..3488,3576..3578,3585..3587)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..651
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..830
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..997
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1268
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1362
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1464
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1616
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1755
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1899
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2196
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2433
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2701
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2831
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2960
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3098
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3224
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3346
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3539
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..5312
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagctctt gccaggtaaa aagttttggg aaacagatga atccagcaaa gatggaccaa
      601 aaggaatatt cctgggtgat caatggcgag acagtgcctg gggaacatca gatcattcag
      661 tttcccagcc aatcatggtg cagagaagac ctggtcagag tttccatgtg aacagtgagg
      721 tcaattctgt actgtcccca cgatcggaga gtgggggact aggcgttagc atggtggagt
      781 atgtgttgag ctcatccccg ggcgattcct gtctaagaaa aggaggattt ggcccaaggg
      841 atgcagacag tgatgaaaac gacaaaggtg aaaagaagaa caagggtgcg tttgatggag
      901 ataagctagg agatttgaag gaggagggag atgtgatgga caagaccaat ggtttgccag
      961 tgcagaatgg gattgatgca gacgtcaaag attttagccg tacccctggt aattgccaga
     1021 gctctgctaa tgaagtggat cttctgggtc caaaccagaa tggttctgag ggcttagccc
     1081 agctgaccag caccaatggt gccaagcctg tggaggattt ctccaacatg gagtcccaga
     1141 gtgtcccctt ggaccccatg gaacatgtgg gcatggagcc tctgcagttt gattattcag
     1201 gcacgcaggt acctgtggac tcagcagcag caacagtggg actttttgac tacaattctc
     1261 aacaacagct attccaaaga cccaatgcgc ttgctgttca gcagttgaca gctgcccagc
     1321 agcagcaata tgcacttgca gcagcccacc agcctcacat cggtttagct cccgctgcgt
     1381 ttgtccccaa cccatacatc atcagcgctg ctcccccagg gacggacccc tacacagctg
     1441 gattggctgc agcagcgaca ctcggcccag ctgtggtccc tcaccaatat tatggagtca
     1501 cgccatgggg tgtctatcct gctagtcttt tccagcaaca agctgctgca gctgcagcag
     1561 caacaaattc agctactcag cagagtgccc cacaggccca gcagggacag cagcaggttc
     1621 ttcgtggagg agctagccag cgtcctttga ccccaaatca gaaccagcag ggacaacaaa
     1681 cagatcccct tgtagcagct gcagcagtga actctgctct tgcctttgga caaggattgg
     1741 ctgcaggtat gccaggttat ccagtcttgg cacctgctgc ttactatgac caaactggtg
     1801 cccttgtggt gaatgcaggg gcaagaaatg gcctcggagc tccagttcgg cttgttgctc
     1861 cagccccagt catcattagc tcctcagctg cacaagcagc tgttgcagcg gctgcagctt
     1921 cagcaaatgg agcagccggt ggtcttgcag gaactacaaa tggaccattt cgacctttag
     1981 gcacccagca gccccagccc cagccccagc agcagcccag taacaatctg gcttccagct
     2041 ctttctatgg caacaactct ctgagcagta actcccagag cagctccctc ttctctcagg
     2101 gctccgccca gcctgccaac acgtccttgg gattcggaag cagcagttcc cttggtgcca
     2161 ccctaggatc ggcccttgga gggtttggaa cagcagttgc aaactccaac actggcagtg
     2221 gctcccgccg tgactccctg actggcagca gtgaccttta taagaggaca tcgagcagct
     2281 tggcccccat tggacacagt ttttataaca gccttagctt ttcctcctct cctggacccg
     2341 tgggcatgcc tctccctagt cagggaccag gacattcaca gacaccacct ccttccctct
     2401 cttcacatgg atcctcttca agcttaaacc tgggaggact cacgaacggc agtggaagat
     2461 acatctctgc tgctcctggt gccgaagcca agtaccgcag tgcgagcagt gcctccagcc
     2521 ttttcagccc cagcagcacc cttttttctt cctctcgttt gagatacgga atgtctgatg
     2581 ttatgccctc tggcaggagc agacttctgg aagactttcg aaacaaccgg taccctaatt
     2641 tacaactgcg ggagattgcc gggcatataa tggaattttc ccaagaccag catggttcta
     2701 gattcattca gctgaaacta gagcgagcca cagcagctga gcgccagctt gtcttcaacg
     2761 aaatcctgca ggctgcgtac caacttatgg tggatgtgtt tggaaattac gtcattcaga
     2821 agttctttga atttggcagc catgaacaga agctggcttt ggctgaacgg attcgaggcc
     2881 acgtcctatc attggcactg cagatgtatg gctgccgagt catccagaaa gctttggaat
     2941 ttattccctc agaccagcag aacgagatgg tgcgggagct agatggccat gtcctgaagt
     3001 gtgtgaaaga ccagaatggc aaccatgtgg ttcagaagtg cattgaatgt gtacagcccc
     3061 agtctttgca gttcatcatc gatgcattca aggggcaggt gtttgctttg tctacgcacc
     3121 catatggctg tagggtgatc cagaggatcc tggaacactg tctccccgac cagaccctcc
     3181 ctatcctgga ggagcttcac cagcacacgg agcagctcgt gcaggatcag tatggaaatt
     3241 atgtaatcca acatgtcctg gagcatggtc gtcctgagga taaaagcaaa attgtagcag
     3301 agatccgagg caatgtactt gtattgagtc agcacaaatt cgcaagcaat gttgtggaga
     3361 agtgtgtcac tcacgcctca cgtacagagc gtgctgtgct cattgatgag gtatgcacca
     3421 tgaatgacgg tccccacagt gccttataca ccatgatgaa ggatcagtat gccaattatg
     3481 tggtccagaa gatgatcgat gtggctgagc cggggcagcg gaagattgtc atgcacaaga
     3541 tccggccaca catcgcgact cttcggaagt acacctatgg caagcacatc ctggccaagc
     3601 ttgagaagta ctacatgaag aatggtgtgg acttggggcc catttgtggt ccccctaatg
     3661 ggatcatctg agcagtgcac ccatccctgt cccgctgacc tcactgaccc tggcagatcc
     3721 aaccagcaac cagagatgcc cagctcagag tcgaaagtgg gcgatggttg ctccgggatt
     3781 gctccctcct ccaaaaatgg aatcggatcc acttgtggaa aggcctttgt aaatttcatt
     3841 ttattacaca taacatgtac taattatttt ttttaattga ctaattgccc tgctgtttac
     3901 tggtgtatag gaacttgtac ataggtaatc agtgtacatg agaggccaca tgctttgttc
     3961 aatgttgtat ctatattcca catgtggaca ctttcagggt ggttggttta acaaaaaaag
     4021 ttttaaaaaa agacaaaaaa aggtttttaa ctcatttgcc ttgtggcaag ttttgcaaat
     4081 agctcttccc caccccattt tattaaaaaa agaaacctga gaaatttgaa ttttagttaa
     4141 ataatctcaa actggcattt aacactgttt ataaaatata tatatatata tacatatata
     4201 catatgaaat gggaacgttt ccgagttgct aaagcatcag cctgtgatac ggagtttatg
     4261 acgctctttg gagatgacct catgctgagg gaggtggtag ctgcagatcc aggaggagcg
     4321 ggaagcacag agacaggccg gaggccagtg ggcatggcca cttgctctat gggttgcctt
     4381 ctgtgaacac tgggaagcag aatctgatta tctagcatga gagaacccag ctctgctcct
     4441 ggtctggctt ctatagatac atagtgtata cttgtgtaga ctttgcatat atacggattt
     4501 gtagtatttt cctgttttga tgtctaatct gtatctataa tgtaccctag tagtcggaca
     4561 tacttttgat tgtacaattg tacatttgta tacctgtaat gtaaatgtgg agaagtttga
     4621 atcaacatga acacgttttt ggtaagaaga gaaccggcca gcccgtgcac tctgtatatc
     4681 ccacctttta tggttgtagc agatagtgtt gtatattgta aattgtaatt tcaaacagaa
     4741 gtaaattttt ttcttttgaa ggaataaatg ttctttatac agcctagtta atgtttaaaa
     4801 agaaaaaata gcttggttta tttgtcagct agtcaagacg gtagtgagag cctttctaaa
     4861 tgttacttca gatgattcag ttcacactag tgttcctttt ttttttttta tcctaagaaa
     4921 aggtaatgtt tcgcttattt tgtgacagtc aaaaggatgt gcagaagttt cgcctgcccc
     4981 ttccctgctc accacctccc cttgtaaagt gactcaccct ccgttttgta cagatgagct
     5041 gtattttgca ttttgtctac ttgtaagtga atgtaacata ctgtcaatcc tcgtttgaat
     5101 atagactgta acactacacg gtgtacattt ccagagcctt gtgtatattt ccaatgaact
     5161 ttttgcaagc acacttgtaa ccatatgtgt ataattaaca aacctgtgta tgcttatgcc
     5221 tgggcaacta ttttttgtaa ctcttgtgta gattgtctct aaacaatgtg tgatctttat
     5281 tttgaaaaaa atacagaact ttggaatctg aa
//
LOCUS       NM_001437085            6591 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            14, mRNA.
ACCESSION   NM_001437085 XM_039097187
VERSION     NM_001437085.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6591)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6591)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6591)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6591)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6591)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6591)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6591)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6591)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6591)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6591)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097187.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221525.1, SRR26643292.60189.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-766             JAXUCZ010000018.1  65528841-65528917
            767-967             JAXUCZ010000018.1  65531550-65531750
            968-1103            JAXUCZ010000018.1  65551334-65551469
            1104-1266           JAXUCZ010000018.1  65553405-65553567
            1267-1496           JAXUCZ010000018.1  65556812-65557041
            1497-1637           JAXUCZ010000018.1  65557878-65558018
            1638-6591           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6591
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1633
                     /gene="Tcf4"
                     /note="isoform 14 is encoded by transcript variant 14;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 14"
                     /protein_id="NP_001424014.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPL
                     HSLSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYG
                     TGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRG
                     MPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDD
                     EDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILH
                     QAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQ
                     M"
     misc_feature    1301..1555
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1301..1555
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1325..1327,1337..1339,1343..1351,1355..1357,
                     1370..1372,1433..1438)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1325..1327,1337..1339,1343..1351,1355..1357,
                     1370..1372,1433..1438)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1364..1369,1376..1381,1385..1390,1397..1399,
                     1409..1411,1439..1441,1448..1450,1460..1462,1469..1471,
                     1478..1495)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1364..1369,1376..1381,1385..1390,1397..1399,
                     1409..1411,1439..1441,1448..1450,1460..1462,1469..1471,
                     1478..1495)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..766
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1266
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1496
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1637
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..6591
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagc aggcacagct gtttggtctc gaaacggagg
      721 acaggcctcg tcatctccca attacgaagg acccttgcac tccttgagcc gaattgaaga
      781 ccgtttagaa agactggacg acgcgattca tgttctccgg aaccacgcgg tgggcccatc
      841 cacagctgtg cccggtggcc atggggacat gcatgggatc atcggaccct ctcacaatgg
      901 agcaatgggc agtctgggct caggatatgg aactggcctt ctctcagcca acagacattc
      961 actcatggtc ggggcccacc gtgaagatgg cgtggcactg agaggcagcc attctctcct
     1021 gccaaaccag gttccggttc cacagcttcc agtccagtct gcaacttccc ctgacttgaa
     1081 cccaccccaa gacccttaca gagggatgcc accaggcctc cagggacaga gtgtgtcttc
     1141 cggcagctct gagatcaagt ccgacgacga gggcgatgag aacctacagg acacaaaatc
     1201 ttccgaggac aagaaactag acgacgacaa gaaggatatc aaatcaatta ctaggtcaag
     1261 atctagcaat aacgatgatg aggacctgac cccggagcag aaggccgagc gtgagaagga
     1321 gcggaggatg gccaataacg cccgtgagcg cctgagggtc cgtgatatca acgaggcttt
     1381 caaggagctg ggccgcatgg tacagctcca cctgaagagc gacaagcccc agaccaagct
     1441 cctgattctc caccaggcag tggctgtcat cctcagcctg gagcagcaag tgcgagaaag
     1501 gaacctgaac ccaaaagctg cctgtctgaa aagaagggag gaagagaagg tgtcctcaga
     1561 gcctcccccg ctctccttgg ctggcccaca ccctgggatg ggagacgcag cgaatcacat
     1621 gggtcagatg tgaaagggtc caagttgcca ccttgcttca ttaaaacaag agaccacttc
     1681 cttaacagct gtattatcct aaacccacat aaacactgct ccttaacccc gttttttttg
     1741 taatataaga caagtctgag tagttatgaa tcgcagacgc aagaggtttc agcattccca
     1801 attatcaaaa aacagaaaaa caaacacaaa aaaaaaatga atgaaagaaa gaaagaaaga
     1861 gaaaatgcaa cttgagggac gacttcttta acatatcact ctgaatgtgc gaagcggtat
     1921 gtacaggctg agacgcagcc cagagactga atggcaatcc ttccacactg tggagcaatg
     1981 catttgtgcc taaacttctt ttggaaaaaa aaatataatt aatttgtaag tctgaaaaaa
     2041 aatatttaat ttaaaaaaaa ttgtaaactt gcaataatga aaaagtgtac ttctgaagaa
     2101 aaacgacatg aacgtttttg ttggtattca agtcagctag tgtttctaat taccggatat
     2161 tgaatagagg aagcccggct accctcataa caaaaccagc aaccgtcctg atggcaaccg
     2221 aaatgatgac attagccatt ccttagggta ggagggacag atggatgtta tagacctatg
     2281 acaaatatat atataaatat atatataaat atatattaaa aatttagtga ctatggtaag
     2341 cttttgttca tttgtttcag acttttttct cctgtaaaaa aatagtactg attaactttt
     2401 ttaaaagaaa gattttactg taaatatgga tttttttttg tctgattttt gtcccttccc
     2461 ccagtttgtt atcgtgacct gtagtgccaa ctctgcttcc ggaggggcag tgcaggacga
     2521 aatgctgacc ctgatgttgc ttctcattca taaatagtag aaagttgttt ctccagtctt
     2581 ttgggaacac aggacttaaa agtcacatca tgtgtagaaa ttacatgcag cattgcccgg
     2641 gcaaggcaaa aagagtttgt ctggcttgtg gcactgtgct tgttaccctc tcctgggatt
     2701 ttcagaggta cacggttaga atgctacaat gttaccactg tgccttccaa tgtttatatc
     2761 atcggaaaca tgacataatc aaagtggctg tgatttaaca aaaaaaaaaa aagattcaag
     2821 tgttacctac ctgtgtagcg gaagtagtgt gcagtgagac gtttctgaat acatggtcag
     2881 attttttttg gaaaaaatac aaaaacaaaa aaaaaaaaca aaaaaattta aaaaaaaaag
     2941 tcaagttcaa aaaccgtcaa atgagaaaat cgcaaggagt gtgacagctg attgattttg
     3001 ttgcttttct tgattttttt ttttttgttt ccaaatgggt ttactaaaaa gtacatgact
     3061 tacctgcctc ctccttcgtc tgaaaacaaa aaacaaaaaa acaatgccaa cctatcccac
     3121 agcattatag caagccttat aagccctaaa gcattaagtt gcactttggt gaggaggggt
     3181 agcgcagtat tctctctggc cagtatgagt gaagtttata cttaacattt gatagaaaca
     3241 tagatcaaac tgtggcacag taactcatca gatagctagc gttgactctg ggcacaattg
     3301 aaccaattcc catcctaaat ctttccaaca attgactttg gtgtacagtg cagtgaacac
     3361 atagaactcc tacttaagta ttcgtcagca tccttttgtc tctaactcgg ttctgttttg
     3421 acagccacac aatcttggca tgtattaagt aaaaaaaaaa aaaaaatccc tgttgaagta
     3481 gttttcccac ctatcagcac tgagtaattg ccgtaactca atggaaatgg tctaaacgcc
     3541 ccccatctct tgtcctgtac caccagttac acagtgacaa aacacatctg taaattttat
     3601 gcaaccaatg gcaaacctat cattattttg aaactgtgta tgtaaaagtt atatttttac
     3661 atgtagactc ttgttattat gtgttttaat acattgtatc agttttttgt ttcctttttt
     3721 ttttaactgt gtggttttaa aaagtcattt aaatgaaata gcgagctaca agaatctgaa
     3781 atttatgttc atttctgaaa atgtaagaac aaataagata gttatcacgt ggtcaccttt
     3841 tacaaaccca tcgatgtttt gactagctgt gtgtatgtgt gtgtgtgcgc atgtgtgcgt
     3901 gtgtgtgtat gtgtgttgaa aactgtaaat atgttcagta gcgataaaac gacaatgctt
     3961 tgatttgttg agaagttcct aaaatgtgga ggtggattga aaatgtaggg gaatagcaga
     4021 aatcagattt catgaagagc tcttctcttc gggggctttc ctgtggaatg gtcaaacaga
     4081 ggtgctccaa gaagggcaag gaagacagta acttcccctc ctccctgaac gacggaaacc
     4141 atgtgtacgt ggtctctcac catgttaaag attttctttc cgtgatacat tctgcactct
     4201 ttttgtatag tctaccaagg cgggtatccc tgggaacaat attatgatat aggaagcagt
     4261 atactctgat cacattcagg agaattgtat agaagagaat atggtgttta ctctttaggg
     4321 aactggaaat tctccctgca ttgatgtaca tcttcagagc ggcccttttg atacacgtta
     4381 tcataaaggt gctgactaaa gcagaattaa agtttttcaa atctgtaaac aaagcaaaaa
     4441 attaaattac agtcattcga ttgtttgttt tttttttttt ccaattggtg cttttatatt
     4501 ttgttctcac tcagacagaa aaggctgcaa tttcttgttc accagctttg atgtattcat
     4561 tactcggtaa tgtaatacgg ctattgtcaa attccttttg gaaataagca aaaggcttcc
     4621 ccaaggcctg cagcagctgc tggctacttt ctgcttggcg cagaaacatg atctgaccct
     4681 ctctgtagta atcgagttgt atctccagtt ttaaaaagaa ggaaaaaggg aatgtggccg
     4741 ttttaatgtg tttttttttt tcttttcttg ttgttatttt gtaattctca aacccaggta
     4801 agatattggt attcctgcac tggatttttg aaagaaactt agcagaagac aggatcgaga
     4861 tactatagaa gcatttccca agtgttcata ctatactaga cataaatgat aacggcgatg
     4921 tataggttca ggatcggttt aagagactca gactttgaaa gcaacttgga acggttgatc
     4981 cacctccaca ttcgagtaat taataattct gcagaattag ggatctgtcc atctaggagt
     5041 tgttacccat ttgtcttctg tgtggctgcg aggaacacta acgcttttac aactgtcagt
     5101 tcacccagtg gtacaactga ttctgactca gtcttccgat tcctgttttg tattttgttt
     5161 ttccactttt ttcctatctc ttgattttat tgttgttgtt attgctattg ttattattat
     5221 tattcgtgat ctttatttcg atgaggggtt gggaagtggg agggagtcga actgagacta
     5281 ggggttgaga ggattttttt ggtttggttt tcttttcttt tttttttgtt tttttttttt
     5341 tttgtttgtt tgtttcatct ttgcgtccaa caggcagaat atggtctgtg tccaaaacgg
     5401 aacttaagtc aggaaggaaa ccattcagcg taaacaagca caacatgtag tctgtcggct
     5461 gtctggaagc aaaaataaat taataaataa ataataaata agtaaaagac acacacggag
     5521 gtgaagatga aatgtgatgg attccgagac aatggggcac caaggcctgt aggcctcctc
     5581 ttgattttgc tttggttatg tttgttttcc ttagagatgt ttttttcctc acgggacttg
     5641 aagtgactca tctctgtgca gtaatggttt cgccatatgc tcatttcaag tattatagac
     5701 atatgtaatg gtgaaatata tgaactgtgg cctttttcat tcttgttatt tgtgatgcaa
     5761 ttaagtgaag agaagaaaaa aaaaagcaga gatttaccat gtatcagtgc ctggcttttt
     5821 gttataaagc ttcgtctgtc tagtgctctt tttgctataa aaatagactg tagtacaccc
     5881 tagtaggaaa aaaaaaccct aaatttaaaa ataaaaaaat atatttggct tatttttcgc
     5941 aggagcaatc cttttatacc atggatatta caaaaaaaaa aattgtcaga ttctgaatat
     6001 ttcttctttg tagatttttg gaatcattat aagtaaaagt ttgttacttt attttactat
     6061 ttaaaagatg ttattttgcc atgtgttact gagatgaaac tgtatggtat agcttcttct
     6121 gttcgttttt tgtttccggt tttttgtttg ttcgtttttg gttttttttt tttttgtttg
     6181 tttgttttgt tttgtttttt tttcttagtt gtaggtcgca gtaaggactt ttccttttgt
     6241 ttttgttttt tcgttatgtt ttgttttgtt tttgcgactg tacacatagc tgcagcatta
     6301 aaaactttta aaaaaatctg ttaaaaaaaa aagaaaaaaa agggaaaacg tttaaaaaaa
     6361 aaagataaac agttacacct tgttttcaac gtgtggctga gtgcctcgat tttttcatgt
     6421 ttttggtgta tttctgattt gtagaagtgt ccaaacaggt tgtgtcctgg acttccttca
     6481 agaggcgaac aacccagctt ggtctaggcc atgacctgtt cccatctgta gttactcgat
     6541 gaagtcatgt acatgaccgt tctgtagcaa taaatgtgcc atttttataa a
//
LOCUS       NM_001437067            7452 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            5, mRNA.
ACCESSION   NM_001437067 XM_063277624
VERSION     NM_001437067.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7452)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7452)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7452)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7452)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7452)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7452)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7452)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7452)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7452)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7452)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277624.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1776742.1,
                                           SRR26360186.1645629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-632             JAXUCZ010000018.1  65221421-65221493
            633-694             JAXUCZ010000018.1  65334541-65334602
            695-791             JAXUCZ010000018.1  65337982-65338078
            792-853             JAXUCZ010000018.1  65391770-65391831
            854-983             JAXUCZ010000018.1  65437939-65438068
            984-1033            JAXUCZ010000018.1  65438528-65438577
            1034-1139           JAXUCZ010000018.1  65507173-65507278
            1140-1270           JAXUCZ010000018.1  65511025-65511155
            1271-1403           JAXUCZ010000018.1  65516916-65517048
            1404-1471           JAXUCZ010000018.1  65525175-65525242
            1472-1550           JAXUCZ010000018.1  65526319-65526397
            1551-1624           JAXUCZ010000018.1  65528844-65528917
            1625-1828           JAXUCZ010000018.1  65531547-65531750
            1829-1964           JAXUCZ010000018.1  65551334-65551469
            1965-2127           JAXUCZ010000018.1  65553405-65553567
            2128-2357           JAXUCZ010000018.1  65556812-65557041
            2358-2498           JAXUCZ010000018.1  65557878-65558018
            2499-7452           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7452
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    536..538
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             560..2494
                     /gene="Tcf4"
                     /note="isoform 5 is encoded by transcript variant 5;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 5"
                     /protein_id="NP_001423996.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLL
                     GGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVY
                     APSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLG
                     NSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANG
                     TDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSGTAV
                     WSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMH
                     GIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQL
                     PVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLD
                     DDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGR
                     MVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPP
                     LSLAGPHPGMGDAANHMGQM"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2162..2416
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2162..2416
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2186..2188,2198..2200,2204..2212,2216..2218,
                     2231..2233,2294..2299)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2186..2188,2198..2200,2204..2212,2216..2218,
                     2231..2233,2294..2299)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2225..2230,2237..2242,2246..2251,2258..2260,
                     2270..2272,2300..2302,2309..2311,2321..2323,2330..2332,
                     2339..2356)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2225..2230,2237..2242,2246..2251,2258..2260,
                     2270..2272,2300..2302,2309..2311,2321..2323,2330..2332,
                     2339..2356)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            560..632
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..694
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..791
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..853
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..983
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1033
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1139
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1270
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1403
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1471
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1550
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1624
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1828
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1964
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2127
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2357
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2498
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..7452
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaaga tgttttcgcc tcctgtaagc agtgggaaaa atggaccaac
      601 ttctttggcg agtggacatt ttacgggctc aaatgtagaa gacagaagta gctcagggtc
      661 ctgggggaat ggaggtcatc caagcccgtc caggaactat ggagatggga ctccctatga
      721 ccacatgact agcagggatc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc
      781 cagaatacaa agtaaaacag aaaggggttc atactcatct tatgggagag aaaacgtaca
      841 gggttgccac cagcagagtc tcctcggagg ggacatggat atgggcaacc caggaaccct
      901 ttcgcccacc aaacctggct cccagtacta cccatattcc agcaataacg cccgacggag
      961 gcctcttcac agtagtacca tggaggtgca gacaaagaaa gtcagaaaag ttcctccagg
     1021 cttgccatct tcagtctacg ctccttcagc cagcactgcc gactacaaca gggactcacc
     1081 aggctattct tcctccaagc cagcagccag cactttctcc agctccttct tcatgcaaga
     1141 tggccatcac agcagtgacc cttggagctc ctccagtgga atgaatcagc ccggctatgg
     1201 agggatgcta ggcaactctc atatcccaca gtctagcagc tactgtagcc tgcatccaca
     1261 tgaacgtctg agctatccat cgcactcctc ggcagacatc aactccagtc ttcctccgat
     1321 gtccacgttc catcgaagtg gcacaaacca ttacagcacc tcttcctgca cacctcctgc
     1381 caacggaaca gacagtataa tggcaaacag aggaactggg gcagcaggca gctcccagac
     1441 tggagacgct ctggggaaag ccctggcttc gatctattct cctgatcaca cgaacaacag
     1501 cttctcctcc aacccttcaa ctcctgttgg ctcccctcct tcactctcag gcacagctgt
     1561 ttggtctcga aacggaggac aggcctcgtc atctcccaat tacgaaggac ccttgcactc
     1621 cttgcagagc cgaattgaag accgtttaga aagactggac gacgcgattc atgttctccg
     1681 gaaccacgcg gtgggcccat ccacagctgt gcccggtggc catggggaca tgcatgggat
     1741 catcggaccc tctcacaatg gagcaatggg cagtctgggc tcaggatatg gaactggcct
     1801 tctctcagcc aacagacatt cactcatggt cggggcccac cgtgaagatg gcgtggcact
     1861 gagaggcagc cattctctcc tgccaaacca ggttccggtt ccacagcttc cagtccagtc
     1921 tgcaacttcc cctgacttga acccacccca agacccttac agagggatgc caccaggcct
     1981 ccagggacag agtgtgtctt ccggcagctc tgagatcaag tccgacgacg agggcgatga
     2041 gaacctacag gacacaaaat cttccgagga caagaaacta gacgacgaca agaaggatat
     2101 caaatcaatt actaggtcaa gatctagcaa taacgatgat gaggacctga ccccggagca
     2161 gaaggccgag cgtgagaagg agcggaggat ggccaataac gcccgtgagc gcctgagggt
     2221 ccgtgatatc aacgaggctt tcaaggagct gggccgcatg gtacagctcc acctgaagag
     2281 cgacaagccc cagaccaagc tcctgattct ccaccaggca gtggctgtca tcctcagcct
     2341 ggagcagcaa gtgcgagaaa ggaacctgaa cccaaaagct gcctgtctga aaagaaggga
     2401 ggaagagaag gtgtcctcag agcctccccc gctctccttg gctggcccac accctgggat
     2461 gggagacgca gcgaatcaca tgggtcagat gtgaaagggt ccaagttgcc accttgcttc
     2521 attaaaacaa gagaccactt ccttaacagc tgtattatcc taaacccaca taaacactgc
     2581 tccttaaccc cgtttttttt gtaatataag acaagtctga gtagttatga atcgcagacg
     2641 caagaggttt cagcattccc aattatcaaa aaacagaaaa acaaacacaa aaaaaaaatg
     2701 aatgaaagaa agaaagaaag agaaaatgca acttgaggga cgacttcttt aacatatcac
     2761 tctgaatgtg cgaagcggta tgtacaggct gagacgcagc ccagagactg aatggcaatc
     2821 cttccacact gtggagcaat gcatttgtgc ctaaacttct tttggaaaaa aaaatataat
     2881 taatttgtaa gtctgaaaaa aaatatttaa tttaaaaaaa attgtaaact tgcaataatg
     2941 aaaaagtgta cttctgaaga aaaacgacat gaacgttttt gttggtattc aagtcagcta
     3001 gtgtttctaa ttaccggata ttgaatagag gaagcccggc taccctcata acaaaaccag
     3061 caaccgtcct gatggcaacc gaaatgatga cattagccat tccttagggt aggagggaca
     3121 gatggatgtt atagacctat gacaaatata tatataaata tatatataaa tatatattaa
     3181 aaatttagtg actatggtaa gcttttgttc atttgtttca gacttttttc tcctgtaaaa
     3241 aaatagtact gattaacttt tttaaaagaa agattttact gtaaatatgg attttttttt
     3301 gtctgatttt tgtcccttcc cccagtttgt tatcgtgacc tgtagtgcca actctgcttc
     3361 cggaggggca gtgcaggacg aaatgctgac cctgatgttg cttctcattc ataaatagta
     3421 gaaagttgtt tctccagtct tttgggaaca caggacttaa aagtcacatc atgtgtagaa
     3481 attacatgca gcattgcccg ggcaaggcaa aaagagtttg tctggcttgt ggcactgtgc
     3541 ttgttaccct ctcctgggat tttcagaggt acacggttag aatgctacaa tgttaccact
     3601 gtgccttcca atgtttatat catcggaaac atgacataat caaagtggct gtgatttaac
     3661 aaaaaaaaaa aaagattcaa gtgttaccta cctgtgtagc ggaagtagtg tgcagtgaga
     3721 cgtttctgaa tacatggtca gatttttttt ggaaaaaata caaaaacaaa aaaaaaaaac
     3781 aaaaaaattt aaaaaaaaaa gtcaagttca aaaaccgtca aatgagaaaa tcgcaaggag
     3841 tgtgacagct gattgatttt gttgcttttc ttgatttttt tttttttgtt tccaaatggg
     3901 tttactaaaa agtacatgac ttacctgcct cctccttcgt ctgaaaacaa aaaacaaaaa
     3961 aacaatgcca acctatccca cagcattata gcaagcctta taagccctaa agcattaagt
     4021 tgcactttgg tgaggagggg tagcgcagta ttctctctgg ccagtatgag tgaagtttat
     4081 acttaacatt tgatagaaac atagatcaaa ctgtggcaca gtaactcatc agatagctag
     4141 cgttgactct gggcacaatt gaaccaattc ccatcctaaa tctttccaac aattgacttt
     4201 ggtgtacagt gcagtgaaca catagaactc ctacttaagt attcgtcagc atccttttgt
     4261 ctctaactcg gttctgtttt gacagccaca caatcttggc atgtattaag taaaaaaaaa
     4321 aaaaaaatcc ctgttgaagt agttttccca cctatcagca ctgagtaatt gccgtaactc
     4381 aatggaaatg gtctaaacgc cccccatctc ttgtcctgta ccaccagtta cacagtgaca
     4441 aaacacatct gtaaatttta tgcaaccaat ggcaaaccta tcattatttt gaaactgtgt
     4501 atgtaaaagt tatattttta catgtagact cttgttatta tgtgttttaa tacattgtat
     4561 cagttttttg tttccttttt tttttaactg tgtggtttta aaaagtcatt taaatgaaat
     4621 agcgagctac aagaatctga aatttatgtt catttctgaa aatgtaagaa caaataagat
     4681 agttatcacg tggtcacctt ttacaaaccc atcgatgttt tgactagctg tgtgtatgtg
     4741 tgtgtgtgcg catgtgtgcg tgtgtgtgta tgtgtgttga aaactgtaaa tatgttcagt
     4801 agcgataaaa cgacaatgct ttgatttgtt gagaagttcc taaaatgtgg aggtggattg
     4861 aaaatgtagg ggaatagcag aaatcagatt tcatgaagag ctcttctctt cgggggcttt
     4921 cctgtggaat ggtcaaacag aggtgctcca agaagggcaa ggaagacagt aacttcccct
     4981 cctccctgaa cgacggaaac catgtgtacg tggtctctca ccatgttaaa gattttcttt
     5041 ccgtgataca ttctgcactc tttttgtata gtctaccaag gcgggtatcc ctgggaacaa
     5101 tattatgata taggaagcag tatactctga tcacattcag gagaattgta tagaagagaa
     5161 tatggtgttt actctttagg gaactggaaa ttctccctgc attgatgtac atcttcagag
     5221 cggccctttt gatacacgtt atcataaagg tgctgactaa agcagaatta aagtttttca
     5281 aatctgtaaa caaagcaaaa aattaaatta cagtcattcg attgtttgtt tttttttttt
     5341 tccaattggt gcttttatat tttgttctca ctcagacaga aaaggctgca atttcttgtt
     5401 caccagcttt gatgtattca ttactcggta atgtaatacg gctattgtca aattcctttt
     5461 ggaaataagc aaaaggcttc cccaaggcct gcagcagctg ctggctactt tctgcttggc
     5521 gcagaaacat gatctgaccc tctctgtagt aatcgagttg tatctccagt tttaaaaaga
     5581 aggaaaaagg gaatgtggcc gttttaatgt gttttttttt ttcttttctt gttgttattt
     5641 tgtaattctc aaacccaggt aagatattgg tattcctgca ctggattttt gaaagaaact
     5701 tagcagaaga caggatcgag atactataga agcatttccc aagtgttcat actatactag
     5761 acataaatga taacggcgat gtataggttc aggatcggtt taagagactc agactttgaa
     5821 agcaacttgg aacggttgat ccacctccac attcgagtaa ttaataattc tgcagaatta
     5881 gggatctgtc catctaggag ttgttaccca tttgtcttct gtgtggctgc gaggaacact
     5941 aacgctttta caactgtcag ttcacccagt ggtacaactg attctgactc agtcttccga
     6001 ttcctgtttt gtattttgtt tttccacttt tttcctatct cttgatttta ttgttgttgt
     6061 tattgctatt gttattatta ttattcgtga tctttatttc gatgaggggt tgggaagtgg
     6121 gagggagtcg aactgagact aggggttgag aggatttttt tggtttggtt ttcttttctt
     6181 ttttttttgt tttttttttt ttttgtttgt ttgtttcatc tttgcgtcca acaggcagaa
     6241 tatggtctgt gtccaaaacg gaacttaagt caggaaggaa accattcagc gtaaacaagc
     6301 acaacatgta gtctgtcggc tgtctggaag caaaaataaa ttaataaata aataataaat
     6361 aagtaaaaga cacacacgga ggtgaagatg aaatgtgatg gattccgaga caatggggca
     6421 ccaaggcctg taggcctcct cttgattttg ctttggttat gtttgttttc cttagagatg
     6481 tttttttcct cacgggactt gaagtgactc atctctgtgc agtaatggtt tcgccatatg
     6541 ctcatttcaa gtattataga catatgtaat ggtgaaatat atgaactgtg gcctttttca
     6601 ttcttgttat ttgtgatgca attaagtgaa gagaagaaaa aaaaaagcag agatttacca
     6661 tgtatcagtg cctggctttt tgttataaag cttcgtctgt ctagtgctct ttttgctata
     6721 aaaatagact gtagtacacc ctagtaggaa aaaaaaaccc taaatttaaa aataaaaaaa
     6781 tatatttggc ttatttttcg caggagcaat ccttttatac catggatatt acaaaaaaaa
     6841 aaattgtcag attctgaata tttcttcttt gtagattttt ggaatcatta taagtaaaag
     6901 tttgttactt tattttacta tttaaaagat gttattttgc catgtgttac tgagatgaaa
     6961 ctgtatggta tagcttcttc tgttcgtttt ttgtttccgg ttttttgttt gttcgttttt
     7021 ggtttttttt ttttttgttt gtttgttttg ttttgttttt ttttcttagt tgtaggtcgc
     7081 agtaaggact tttccttttg tttttgtttt ttcgttatgt tttgttttgt ttttgcgact
     7141 gtacacatag ctgcagcatt aaaaactttt aaaaaaatct gttaaaaaaa aaagaaaaaa
     7201 aagggaaaac gtttaaaaaa aaaagataaa cagttacacc ttgttttcaa cgtgtggctg
     7261 agtgcctcga ttttttcatg tttttggtgt atttctgatt tgtagaagtg tccaaacagg
     7321 ttgtgtcctg gacttccttc aagaggcgaa caacccagct tggtctaggc catgacctgt
     7381 tcccatctgt agttactcga tgaagtcatg tacatgaccg ttctgtagca ataaatgtgc
     7441 catttttata aa
//
LOCUS       NM_001437030            1693 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 17, mRNA.
ACCESSION   NM_001437030
VERSION     NM_001437030.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.53239.1,
                                           SRR26360194.1264410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-218              JAXUCZ010000016.1  6898222-6898371
            219-1693            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1693
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..218
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1391
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 3 is encoded by transcript variant 17;
                     biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 3"
                     /protein_id="NP_001423959.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGT
                     KQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFD
                     TPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATA
                     FGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTEN
                     TTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVP
                     VWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGG
                     AGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRK
                     RGLSSGLVTAALYGRLYERN"
     misc_feature    <171..842
                     /gene="Btd"
                     /note="Nitrilase superfamily, including nitrile- or
                     amide-hydrolyzing enzymes and amide-condensing enzymes;
                     Region: nitrilase; cl11424"
                     /db_xref="CDD:448250"
     misc_feature    <171..842
                     /gene="Btd"
                     /note="Nitrilase superfamily, including nitrile- or
                     amide-hydrolyzing enzymes and amide-condensing enzymes;
                     Region: nitrilase; cl11424"
                     /db_xref="CDD:448250"
     misc_feature    order(393..395,405..407,411..413,492..497,501..506,
                     570..572)
                     /gene="Btd"
                     /note="active site"
                     /db_xref="CDD:143591"
     misc_feature    order(393..395,405..407,411..413,492..497,501..506,
                     570..572)
                     /gene="Btd"
                     /note="active site"
                     /db_xref="CDD:143591"
     misc_feature    order(396..410,429..437,495..497,501..515,522..527,
                     588..593,597..605,609..614,684..689,828..839)
                     /gene="Btd"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143591"
     misc_feature    order(396..410,429..437,495..497,501..515,522..527,
                     588..593,597..605,609..614,684..689,828..839)
                     /gene="Btd"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143591"
     misc_feature    936..1385
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    936..1385
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            219..1693
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcaggg tgcgcacatt atagtgttcc cagaagacgg tatccacgga ttcaacttca
      121 caagaacatc catttaccca ttcttggact tgatgccatc tcccaggctg gtcagttgga
      181 acccgtgtct ggagcccttt cgcttcaatg acacggaggt cctccagcgc ctgagttgca
      241 tggccatcaa gggaaagatg ttcttggtgg ccaatcttgg gacaaaacag ccttgcctcg
      301 gcagcgaccc tgggtgcccg caggacggga gataccagtt taacacaaac gtcgcgttca
      361 gtgacaacgg aaccctcgtc ggccgctacc gtaagcacaa cctgtacttt gaggaagcct
      421 tcgatagccc tgctgacgtg gacctcacca cctttgatac gccgttcgcg ggcaagttcg
      481 gtatgttcac ttgctttgat atcctgttct ttgaccccgc ggtccggctc ctcagagact
      541 ttgaggtaaa gcacattgcg taccctacgg cctggatgaa ccagctgccg ctcttggcag
      601 ccattgaaat ccagaaagca ttcgccaccg ccttcggcgt caccgttctg gcagctaaca
      661 tccaccaccc gactctgggg atgacgggca gtggcataca cacccctctg aagtcctttt
      721 ggtaccataa catggacgac cccgaaggtc accttataat tgcccgggta gccacaaacc
      781 cacagggcct cgttgggaca gagaatacaa ctagtgaaat ggatccgtcc cataggaagt
      841 tcttaaaagt cttgtctggg gatccgtact gtgagaagga tgcccaggaa gtgcgctgcg
      901 acgaggctgc caagtggaac ctgaacgcac cacctacctt ccactcggag atgatgtatg
      961 acaatttcac cctggtcccc gtctggggaa aggaaggcca cctccaggtg tgctccaaca
     1021 gtctctgttg ccacttactt ttcgagaggc ccgccctgtc caaagagcta tatgccctgg
     1081 gtgtctttga cggactccac acagtgcacg gtacctacta cgttcaagcc tgtgccctgg
     1141 tcaagtgcgg gggcgctggc tttgaaacct gcgggcagga gatctcggag gccgagggct
     1201 tgtttgactt tcatctgtgg gggaacttca gcaccttgta tgtcttccct ttatttctca
     1261 cctcggggat gaccctagac acccctgacc agctcgggtg ggagagcgac cactatttct
     1321 tgaggaagag gggactgtcc tccggcctgg tgacggcagc tctctatggg cggttgtatg
     1381 agaggaatta ggaaaactgt ggtcagcagg ttgggctctg caggctggcc ttgccttccc
     1441 acggcccaca gatcccaaac actgggaaaa ccgccccgcc cctgtggcac tggatcccac
     1501 cctggggaac tgtaagaaga tgggagaggc agttcctcct tcctttctac ataatgactg
     1561 agatattttc tggtattttc tattcacatt attctttttc aagccacacc ctcttaccac
     1621 tactacacaa ttggttttaa agactaagcc aaaaaaaaaa aaaaaaaata aacatcagct
     1681 gccattctac aaa
//
LOCUS       NM_001437065            7139 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            3, mRNA.
ACCESSION   NM_001437065 XM_063277619
VERSION     NM_001437065.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7139)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7139)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7139)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7139)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7139)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7139)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7139)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7139)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7139)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7139)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74598.1,
                                           SRR21887620.904550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000018.1  65218587-65218749
            164-255             JAXUCZ010000018.1  65219645-65219736
            256-328             JAXUCZ010000018.1  65221421-65221493
            329-390             JAXUCZ010000018.1  65334541-65334602
            391-487             JAXUCZ010000018.1  65337982-65338078
            488-549             JAXUCZ010000018.1  65391770-65391831
            550-679             JAXUCZ010000018.1  65437939-65438068
            680-729             JAXUCZ010000018.1  65438528-65438577
            730-835             JAXUCZ010000018.1  65507173-65507278
            836-966             JAXUCZ010000018.1  65511025-65511155
            967-1099            JAXUCZ010000018.1  65516916-65517048
            1100-1167           JAXUCZ010000018.1  65525175-65525242
            1168-1246           JAXUCZ010000018.1  65526319-65526397
            1247-1323           JAXUCZ010000018.1  65528841-65528917
            1324-1527           JAXUCZ010000018.1  65531547-65531750
            1528-1663           JAXUCZ010000018.1  65551334-65551469
            1664-1814           JAXUCZ010000018.1  65553405-65553555
            1815-2044           JAXUCZ010000018.1  65556812-65557041
            2045-2185           JAXUCZ010000018.1  65557878-65558018
            2186-7139           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7139
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..163
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            164..255
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2181
                     /gene="Tcf4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 3"
                     /protein_id="NP_001423994.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLD
                     DAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVG
                     AHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS
                     SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMA
                     NNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNL
                     NPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    424..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    424..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1849..2103
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1849..2103
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1873..1875,1885..1887,1891..1899,1903..1905,
                     1918..1920,1981..1986)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1873..1875,1885..1887,1891..1899,1903..1905,
                     1918..1920,1981..1986)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1912..1917,1924..1929,1933..1938,1945..1947,
                     1957..1959,1987..1989,1996..1998,2008..2010,2017..2019,
                     2026..2043)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1912..1917,1924..1929,1933..1938,1945..1947,
                     1957..1959,1987..1989,1996..1998,2008..2010,2017..2019,
                     2026..2043)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            256..328
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..390
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..679
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..729
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..835
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1099
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1167
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1323
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1527
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1663
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1814
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2044
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2185
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..7139
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcgg atcggcggcg gcggcggcgg cggcggcggg gaagccggag cgggcgcggg
       61 cgccggccgt tggaggaggt ggtggtggcg gaggcagggg gatagacatg accgccgcct
      121 gggcgccggc gctgcaccgg gagcccctcg tcgcgcgcgg gcggtttgtg tgattttgct
      181 aaaatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct gagtgattta
      241 ctggatttca gtgcgatgtt ttcgcctcct gtaagcagtg ggaaaaatgg accaacttct
      301 ttggcgagtg gacattttac gggctcaaat gtagaagaca gaagtagctc agggtcctgg
      361 gggaatggag gtcatccaag cccgtccagg aactatggag atgggactcc ctatgaccac
      421 atgactagca gggatcttgg gtcacatgac aatctctctc caccttttgt caattccaga
      481 atacaaagta aaacagaaag gggttcatac tcatcttatg ggagagaaaa cgtacagggt
      541 tgccaccagc agagtctcct cggaggggac atggatatgg gcaacccagg aaccctttcg
      601 cccaccaaac ctggctccca gtactaccca tattccagca ataacgcccg acggaggcct
      661 cttcacagta gtaccatgga ggtgcagaca aagaaagtca gaaaagttcc tccaggcttg
      721 ccatcttcag tctacgctcc ttcagccagc actgccgact acaacaggga ctcaccaggc
      781 tattcttcct ccaagccagc agccagcact ttctccagct ccttcttcat gcaagatggc
      841 catcacagca gtgacccttg gagctcctcc agtggaatga atcagcccgg ctatggaggg
      901 atgctaggca actctcatat cccacagtct agcagctact gtagcctgca tccacatgaa
      961 cgtctgagct atccatcgca ctcctcggca gacatcaact ccagtcttcc tccgatgtcc
     1021 acgttccatc gaagtggcac aaaccattac agcacctctt cctgcacacc tcctgccaac
     1081 ggaacagaca gtataatggc aaacagagga actggggcag caggcagctc ccagactgga
     1141 gacgctctgg ggaaagccct ggcttcgatc tattctcctg atcacacgaa caacagcttc
     1201 tcctccaacc cttcaactcc tgttggctcc cctccttcac tctcagcagg cacagctgtt
     1261 tggtctcgaa acggaggaca ggcctcgtca tctcccaatt acgaaggacc cttgcactcc
     1321 ttgcagagcc gaattgaaga ccgtttagaa agactggacg acgcgattca tgttctccgg
     1381 aaccacgcgg tgggcccatc cacagctgtg cccggtggcc atggggacat gcatgggatc
     1441 atcggaccct ctcacaatgg agcaatgggc agtctgggct caggatatgg aactggcctt
     1501 ctctcagcca acagacattc actcatggtc ggggcccacc gtgaagatgg cgtggcactg
     1561 agaggcagcc attctctcct gccaaaccag gttccggttc cacagcttcc agtccagtct
     1621 gcaacttccc ctgacttgaa cccaccccaa gacccttaca gagggatgcc accaggcctc
     1681 cagggacaga gtgtgtcttc cggcagctct gagatcaagt ccgacgacga gggcgatgag
     1741 aacctacagg acacaaaatc ttccgaggac aagaaactag acgacgacaa gaaggatatc
     1801 aaatcaatta ctagcaataa cgatgatgag gacctgaccc cggagcagaa ggccgagcgt
     1861 gagaaggagc ggaggatggc caataacgcc cgtgagcgcc tgagggtccg tgatatcaac
     1921 gaggctttca aggagctggg ccgcatggta cagctccacc tgaagagcga caagccccag
     1981 accaagctcc tgattctcca ccaggcagtg gctgtcatcc tcagcctgga gcagcaagtg
     2041 cgagaaagga acctgaaccc aaaagctgcc tgtctgaaaa gaagggagga agagaaggtg
     2101 tcctcagagc ctcccccgct ctccttggct ggcccacacc ctgggatggg agacgcagcg
     2161 aatcacatgg gtcagatgtg aaagggtcca agttgccacc ttgcttcatt aaaacaagag
     2221 accacttcct taacagctgt attatcctaa acccacataa acactgctcc ttaaccccgt
     2281 tttttttgta atataagaca agtctgagta gttatgaatc gcagacgcaa gaggtttcag
     2341 cattcccaat tatcaaaaaa cagaaaaaca aacacaaaaa aaaaatgaat gaaagaaaga
     2401 aagaaagaga aaatgcaact tgagggacga cttctttaac atatcactct gaatgtgcga
     2461 agcggtatgt acaggctgag acgcagccca gagactgaat ggcaatcctt ccacactgtg
     2521 gagcaatgca tttgtgccta aacttctttt ggaaaaaaaa atataattaa tttgtaagtc
     2581 tgaaaaaaaa tatttaattt aaaaaaaatt gtaaacttgc aataatgaaa aagtgtactt
     2641 ctgaagaaaa acgacatgaa cgtttttgtt ggtattcaag tcagctagtg tttctaatta
     2701 ccggatattg aatagaggaa gcccggctac cctcataaca aaaccagcaa ccgtcctgat
     2761 ggcaaccgaa atgatgacat tagccattcc ttagggtagg agggacagat ggatgttata
     2821 gacctatgac aaatatatat ataaatatat atataaatat atattaaaaa tttagtgact
     2881 atggtaagct tttgttcatt tgtttcagac ttttttctcc tgtaaaaaaa tagtactgat
     2941 taactttttt aaaagaaaga ttttactgta aatatggatt tttttttgtc tgatttttgt
     3001 cccttccccc agtttgttat cgtgacctgt agtgccaact ctgcttccgg aggggcagtg
     3061 caggacgaaa tgctgaccct gatgttgctt ctcattcata aatagtagaa agttgtttct
     3121 ccagtctttt gggaacacag gacttaaaag tcacatcatg tgtagaaatt acatgcagca
     3181 ttgcccgggc aaggcaaaaa gagtttgtct ggcttgtggc actgtgcttg ttaccctctc
     3241 ctgggatttt cagaggtaca cggttagaat gctacaatgt taccactgtg ccttccaatg
     3301 tttatatcat cggaaacatg acataatcaa agtggctgtg atttaacaaa aaaaaaaaaa
     3361 gattcaagtg ttacctacct gtgtagcgga agtagtgtgc agtgagacgt ttctgaatac
     3421 atggtcagat tttttttgga aaaaatacaa aaacaaaaaa aaaaaacaaa aaaatttaaa
     3481 aaaaaaagtc aagttcaaaa accgtcaaat gagaaaatcg caaggagtgt gacagctgat
     3541 tgattttgtt gcttttcttg attttttttt ttttgtttcc aaatgggttt actaaaaagt
     3601 acatgactta cctgcctcct ccttcgtctg aaaacaaaaa acaaaaaaac aatgccaacc
     3661 tatcccacag cattatagca agccttataa gccctaaagc attaagttgc actttggtga
     3721 ggaggggtag cgcagtattc tctctggcca gtatgagtga agtttatact taacatttga
     3781 tagaaacata gatcaaactg tggcacagta actcatcaga tagctagcgt tgactctggg
     3841 cacaattgaa ccaattccca tcctaaatct ttccaacaat tgactttggt gtacagtgca
     3901 gtgaacacat agaactccta cttaagtatt cgtcagcatc cttttgtctc taactcggtt
     3961 ctgttttgac agccacacaa tcttggcatg tattaagtaa aaaaaaaaaa aaaatccctg
     4021 ttgaagtagt tttcccacct atcagcactg agtaattgcc gtaactcaat ggaaatggtc
     4081 taaacgcccc ccatctcttg tcctgtacca ccagttacac agtgacaaaa cacatctgta
     4141 aattttatgc aaccaatggc aaacctatca ttattttgaa actgtgtatg taaaagttat
     4201 atttttacat gtagactctt gttattatgt gttttaatac attgtatcag ttttttgttt
     4261 cctttttttt ttaactgtgt ggttttaaaa agtcatttaa atgaaatagc gagctacaag
     4321 aatctgaaat ttatgttcat ttctgaaaat gtaagaacaa ataagatagt tatcacgtgg
     4381 tcacctttta caaacccatc gatgttttga ctagctgtgt gtatgtgtgt gtgtgcgcat
     4441 gtgtgcgtgt gtgtgtatgt gtgttgaaaa ctgtaaatat gttcagtagc gataaaacga
     4501 caatgctttg atttgttgag aagttcctaa aatgtggagg tggattgaaa atgtagggga
     4561 atagcagaaa tcagatttca tgaagagctc ttctcttcgg gggctttcct gtggaatggt
     4621 caaacagagg tgctccaaga agggcaagga agacagtaac ttcccctcct ccctgaacga
     4681 cggaaaccat gtgtacgtgg tctctcacca tgttaaagat tttctttccg tgatacattc
     4741 tgcactcttt ttgtatagtc taccaaggcg ggtatccctg ggaacaatat tatgatatag
     4801 gaagcagtat actctgatca cattcaggag aattgtatag aagagaatat ggtgtttact
     4861 ctttagggaa ctggaaattc tccctgcatt gatgtacatc ttcagagcgg cccttttgat
     4921 acacgttatc ataaaggtgc tgactaaagc agaattaaag tttttcaaat ctgtaaacaa
     4981 agcaaaaaat taaattacag tcattcgatt gtttgttttt ttttttttcc aattggtgct
     5041 tttatatttt gttctcactc agacagaaaa ggctgcaatt tcttgttcac cagctttgat
     5101 gtattcatta ctcggtaatg taatacggct attgtcaaat tccttttgga aataagcaaa
     5161 aggcttcccc aaggcctgca gcagctgctg gctactttct gcttggcgca gaaacatgat
     5221 ctgaccctct ctgtagtaat cgagttgtat ctccagtttt aaaaagaagg aaaaagggaa
     5281 tgtggccgtt ttaatgtgtt tttttttttc ttttcttgtt gttattttgt aattctcaaa
     5341 cccaggtaag atattggtat tcctgcactg gatttttgaa agaaacttag cagaagacag
     5401 gatcgagata ctatagaagc atttcccaag tgttcatact atactagaca taaatgataa
     5461 cggcgatgta taggttcagg atcggtttaa gagactcaga ctttgaaagc aacttggaac
     5521 ggttgatcca cctccacatt cgagtaatta ataattctgc agaattaggg atctgtccat
     5581 ctaggagttg ttacccattt gtcttctgtg tggctgcgag gaacactaac gcttttacaa
     5641 ctgtcagttc acccagtggt acaactgatt ctgactcagt cttccgattc ctgttttgta
     5701 ttttgttttt ccactttttt cctatctctt gattttattg ttgttgttat tgctattgtt
     5761 attattatta ttcgtgatct ttatttcgat gaggggttgg gaagtgggag ggagtcgaac
     5821 tgagactagg ggttgagagg atttttttgg tttggttttc ttttcttttt tttttgtttt
     5881 tttttttttt tgtttgtttg tttcatcttt gcgtccaaca ggcagaatat ggtctgtgtc
     5941 caaaacggaa cttaagtcag gaaggaaacc attcagcgta aacaagcaca acatgtagtc
     6001 tgtcggctgt ctggaagcaa aaataaatta ataaataaat aataaataag taaaagacac
     6061 acacggaggt gaagatgaaa tgtgatggat tccgagacaa tggggcacca aggcctgtag
     6121 gcctcctctt gattttgctt tggttatgtt tgttttcctt agagatgttt ttttcctcac
     6181 gggacttgaa gtgactcatc tctgtgcagt aatggtttcg ccatatgctc atttcaagta
     6241 ttatagacat atgtaatggt gaaatatatg aactgtggcc tttttcattc ttgttatttg
     6301 tgatgcaatt aagtgaagag aagaaaaaaa aaagcagaga tttaccatgt atcagtgcct
     6361 ggctttttgt tataaagctt cgtctgtcta gtgctctttt tgctataaaa atagactgta
     6421 gtacacccta gtaggaaaaa aaaaccctaa atttaaaaat aaaaaaatat atttggctta
     6481 tttttcgcag gagcaatcct tttataccat ggatattaca aaaaaaaaaa ttgtcagatt
     6541 ctgaatattt cttctttgta gatttttgga atcattataa gtaaaagttt gttactttat
     6601 tttactattt aaaagatgtt attttgccat gtgttactga gatgaaactg tatggtatag
     6661 cttcttctgt tcgttttttg tttccggttt tttgtttgtt cgtttttggt tttttttttt
     6721 tttgtttgtt tgttttgttt tgtttttttt tcttagttgt aggtcgcagt aaggactttt
     6781 ccttttgttt ttgttttttc gttatgtttt gttttgtttt tgcgactgta cacatagctg
     6841 cagcattaaa aacttttaaa aaaatctgtt aaaaaaaaaa gaaaaaaaag ggaaaacgtt
     6901 taaaaaaaaa agataaacag ttacaccttg ttttcaacgt gtggctgagt gcctcgattt
     6961 tttcatgttt ttggtgtatt tctgatttgt agaagtgtcc aaacaggttg tgtcctggac
     7021 ttccttcaag aggcgaacaa cccagcttgg tctaggccat gacctgttcc catctgtagt
     7081 tactcgatga agtcatgtac atgaccgttc tgtagcaata aatgtgccat ttttataaa
//
LOCUS       NM_001437070            7440 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            8, mRNA.
ACCESSION   NM_001437070 XM_063277626
VERSION     NM_001437070.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7440)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7440)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7440)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7440)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7440)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7440)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7440)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7440)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7440)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7440)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277626.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1040193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-632             JAXUCZ010000018.1  65221421-65221493
            633-694             JAXUCZ010000018.1  65334541-65334602
            695-791             JAXUCZ010000018.1  65337982-65338078
            792-853             JAXUCZ010000018.1  65391770-65391831
            854-980             JAXUCZ010000018.1  65437942-65438068
            981-1030            JAXUCZ010000018.1  65438528-65438577
            1031-1136           JAXUCZ010000018.1  65507173-65507278
            1137-1267           JAXUCZ010000018.1  65511025-65511155
            1268-1400           JAXUCZ010000018.1  65516916-65517048
            1401-1468           JAXUCZ010000018.1  65525175-65525242
            1469-1547           JAXUCZ010000018.1  65526319-65526397
            1548-1624           JAXUCZ010000018.1  65528841-65528917
            1625-1828           JAXUCZ010000018.1  65531547-65531750
            1829-1964           JAXUCZ010000018.1  65551334-65551469
            1965-2115           JAXUCZ010000018.1  65553405-65553555
            2116-2345           JAXUCZ010000018.1  65556812-65557041
            2346-2486           JAXUCZ010000018.1  65557878-65558018
            2487-7440           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7440
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    536..538
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             560..2482
                     /gene="Tcf4"
                     /note="isoform 8 is encoded by transcript variant 8;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 8"
                     /protein_id="NP_001423999.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQSLLG
                     GDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVYA
                     PSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGN
                     SHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGT
                     DSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAV
                     WSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMH
                     GIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQL
                     PVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLD
                     DDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQL
                     HLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLA
                     GPHPGMGDAANHMGQM"
     misc_feature    728..>1372
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    728..>1372
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2150..2404
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2150..2404
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2174..2176,2186..2188,2192..2200,2204..2206,
                     2219..2221,2282..2287)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2174..2176,2186..2188,2192..2200,2204..2206,
                     2219..2221,2282..2287)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2213..2218,2225..2230,2234..2239,2246..2248,
                     2258..2260,2288..2290,2297..2299,2309..2311,2318..2320,
                     2327..2344)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2213..2218,2225..2230,2234..2239,2246..2248,
                     2258..2260,2288..2290,2297..2299,2309..2311,2318..2320,
                     2327..2344)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            560..632
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..694
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..791
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..853
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..980
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1030
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1136
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1267
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1400
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1468
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1547
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1624
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1828
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1964
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2115
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2345
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2486
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..7440
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaaga tgttttcgcc tcctgtaagc agtgggaaaa atggaccaac
      601 ttctttggcg agtggacatt ttacgggctc aaatgtagaa gacagaagta gctcagggtc
      661 ctgggggaat ggaggtcatc caagcccgtc caggaactat ggagatggga ctccctatga
      721 ccacatgact agcagggatc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc
      781 cagaatacaa agtaaaacag aaaggggttc atactcatct tatgggagag aaaacgtaca
      841 gggttgccac cagagtctcc tcggagggga catggatatg ggcaacccag gaaccctttc
      901 gcccaccaaa cctggctccc agtactaccc atattccagc aataacgccc gacggaggcc
      961 tcttcacagt agtaccatgg aggtgcagac aaagaaagtc agaaaagttc ctccaggctt
     1021 gccatcttca gtctacgctc cttcagccag cactgccgac tacaacaggg actcaccagg
     1081 ctattcttcc tccaagccag cagccagcac tttctccagc tccttcttca tgcaagatgg
     1141 ccatcacagc agtgaccctt ggagctcctc cagtggaatg aatcagcccg gctatggagg
     1201 gatgctaggc aactctcata tcccacagtc tagcagctac tgtagcctgc atccacatga
     1261 acgtctgagc tatccatcgc actcctcggc agacatcaac tccagtcttc ctccgatgtc
     1321 cacgttccat cgaagtggca caaaccatta cagcacctct tcctgcacac ctcctgccaa
     1381 cggaacagac agtataatgg caaacagagg aactggggca gcaggcagct cccagactgg
     1441 agacgctctg gggaaagccc tggcttcgat ctattctcct gatcacacga acaacagctt
     1501 ctcctccaac ccttcaactc ctgttggctc ccctccttca ctctcagcag gcacagctgt
     1561 ttggtctcga aacggaggac aggcctcgtc atctcccaat tacgaaggac ccttgcactc
     1621 cttgcagagc cgaattgaag accgtttaga aagactggac gacgcgattc atgttctccg
     1681 gaaccacgcg gtgggcccat ccacagctgt gcccggtggc catggggaca tgcatgggat
     1741 catcggaccc tctcacaatg gagcaatggg cagtctgggc tcaggatatg gaactggcct
     1801 tctctcagcc aacagacatt cactcatggt cggggcccac cgtgaagatg gcgtggcact
     1861 gagaggcagc cattctctcc tgccaaacca ggttccggtt ccacagcttc cagtccagtc
     1921 tgcaacttcc cctgacttga acccacccca agacccttac agagggatgc caccaggcct
     1981 ccagggacag agtgtgtctt ccggcagctc tgagatcaag tccgacgacg agggcgatga
     2041 gaacctacag gacacaaaat cttccgagga caagaaacta gacgacgaca agaaggatat
     2101 caaatcaatt actagcaata acgatgatga ggacctgacc ccggagcaga aggccgagcg
     2161 tgagaaggag cggaggatgg ccaataacgc ccgtgagcgc ctgagggtcc gtgatatcaa
     2221 cgaggctttc aaggagctgg gccgcatggt acagctccac ctgaagagcg acaagcccca
     2281 gaccaagctc ctgattctcc accaggcagt ggctgtcatc ctcagcctgg agcagcaagt
     2341 gcgagaaagg aacctgaacc caaaagctgc ctgtctgaaa agaagggagg aagagaaggt
     2401 gtcctcagag cctcccccgc tctccttggc tggcccacac cctgggatgg gagacgcagc
     2461 gaatcacatg ggtcagatgt gaaagggtcc aagttgccac cttgcttcat taaaacaaga
     2521 gaccacttcc ttaacagctg tattatccta aacccacata aacactgctc cttaaccccg
     2581 ttttttttgt aatataagac aagtctgagt agttatgaat cgcagacgca agaggtttca
     2641 gcattcccaa ttatcaaaaa acagaaaaac aaacacaaaa aaaaaatgaa tgaaagaaag
     2701 aaagaaagag aaaatgcaac ttgagggacg acttctttaa catatcactc tgaatgtgcg
     2761 aagcggtatg tacaggctga gacgcagccc agagactgaa tggcaatcct tccacactgt
     2821 ggagcaatgc atttgtgcct aaacttcttt tggaaaaaaa aatataatta atttgtaagt
     2881 ctgaaaaaaa atatttaatt taaaaaaaat tgtaaacttg caataatgaa aaagtgtact
     2941 tctgaagaaa aacgacatga acgtttttgt tggtattcaa gtcagctagt gtttctaatt
     3001 accggatatt gaatagagga agcccggcta ccctcataac aaaaccagca accgtcctga
     3061 tggcaaccga aatgatgaca ttagccattc cttagggtag gagggacaga tggatgttat
     3121 agacctatga caaatatata tataaatata tatataaata tatattaaaa atttagtgac
     3181 tatggtaagc ttttgttcat ttgtttcaga cttttttctc ctgtaaaaaa atagtactga
     3241 ttaacttttt taaaagaaag attttactgt aaatatggat ttttttttgt ctgatttttg
     3301 tcccttcccc cagtttgtta tcgtgacctg tagtgccaac tctgcttccg gaggggcagt
     3361 gcaggacgaa atgctgaccc tgatgttgct tctcattcat aaatagtaga aagttgtttc
     3421 tccagtcttt tgggaacaca ggacttaaaa gtcacatcat gtgtagaaat tacatgcagc
     3481 attgcccggg caaggcaaaa agagtttgtc tggcttgtgg cactgtgctt gttaccctct
     3541 cctgggattt tcagaggtac acggttagaa tgctacaatg ttaccactgt gccttccaat
     3601 gtttatatca tcggaaacat gacataatca aagtggctgt gatttaacaa aaaaaaaaaa
     3661 agattcaagt gttacctacc tgtgtagcgg aagtagtgtg cagtgagacg tttctgaata
     3721 catggtcaga ttttttttgg aaaaaataca aaaacaaaaa aaaaaaacaa aaaaatttaa
     3781 aaaaaaaagt caagttcaaa aaccgtcaaa tgagaaaatc gcaaggagtg tgacagctga
     3841 ttgattttgt tgcttttctt gatttttttt tttttgtttc caaatgggtt tactaaaaag
     3901 tacatgactt acctgcctcc tccttcgtct gaaaacaaaa aacaaaaaaa caatgccaac
     3961 ctatcccaca gcattatagc aagccttata agccctaaag cattaagttg cactttggtg
     4021 aggaggggta gcgcagtatt ctctctggcc agtatgagtg aagtttatac ttaacatttg
     4081 atagaaacat agatcaaact gtggcacagt aactcatcag atagctagcg ttgactctgg
     4141 gcacaattga accaattccc atcctaaatc tttccaacaa ttgactttgg tgtacagtgc
     4201 agtgaacaca tagaactcct acttaagtat tcgtcagcat ccttttgtct ctaactcggt
     4261 tctgttttga cagccacaca atcttggcat gtattaagta aaaaaaaaaa aaaaatccct
     4321 gttgaagtag ttttcccacc tatcagcact gagtaattgc cgtaactcaa tggaaatggt
     4381 ctaaacgccc cccatctctt gtcctgtacc accagttaca cagtgacaaa acacatctgt
     4441 aaattttatg caaccaatgg caaacctatc attattttga aactgtgtat gtaaaagtta
     4501 tatttttaca tgtagactct tgttattatg tgttttaata cattgtatca gttttttgtt
     4561 tccttttttt tttaactgtg tggttttaaa aagtcattta aatgaaatag cgagctacaa
     4621 gaatctgaaa tttatgttca tttctgaaaa tgtaagaaca aataagatag ttatcacgtg
     4681 gtcacctttt acaaacccat cgatgttttg actagctgtg tgtatgtgtg tgtgtgcgca
     4741 tgtgtgcgtg tgtgtgtatg tgtgttgaaa actgtaaata tgttcagtag cgataaaacg
     4801 acaatgcttt gatttgttga gaagttccta aaatgtggag gtggattgaa aatgtagggg
     4861 aatagcagaa atcagatttc atgaagagct cttctcttcg ggggctttcc tgtggaatgg
     4921 tcaaacagag gtgctccaag aagggcaagg aagacagtaa cttcccctcc tccctgaacg
     4981 acggaaacca tgtgtacgtg gtctctcacc atgttaaaga ttttctttcc gtgatacatt
     5041 ctgcactctt tttgtatagt ctaccaaggc gggtatccct gggaacaata ttatgatata
     5101 ggaagcagta tactctgatc acattcagga gaattgtata gaagagaata tggtgtttac
     5161 tctttaggga actggaaatt ctccctgcat tgatgtacat cttcagagcg gcccttttga
     5221 tacacgttat cataaaggtg ctgactaaag cagaattaaa gtttttcaaa tctgtaaaca
     5281 aagcaaaaaa ttaaattaca gtcattcgat tgtttgtttt tttttttttc caattggtgc
     5341 ttttatattt tgttctcact cagacagaaa aggctgcaat ttcttgttca ccagctttga
     5401 tgtattcatt actcggtaat gtaatacggc tattgtcaaa ttccttttgg aaataagcaa
     5461 aaggcttccc caaggcctgc agcagctgct ggctactttc tgcttggcgc agaaacatga
     5521 tctgaccctc tctgtagtaa tcgagttgta tctccagttt taaaaagaag gaaaaaggga
     5581 atgtggccgt tttaatgtgt tttttttttt cttttcttgt tgttattttg taattctcaa
     5641 acccaggtaa gatattggta ttcctgcact ggatttttga aagaaactta gcagaagaca
     5701 ggatcgagat actatagaag catttcccaa gtgttcatac tatactagac ataaatgata
     5761 acggcgatgt ataggttcag gatcggttta agagactcag actttgaaag caacttggaa
     5821 cggttgatcc acctccacat tcgagtaatt aataattctg cagaattagg gatctgtcca
     5881 tctaggagtt gttacccatt tgtcttctgt gtggctgcga ggaacactaa cgcttttaca
     5941 actgtcagtt cacccagtgg tacaactgat tctgactcag tcttccgatt cctgttttgt
     6001 attttgtttt tccacttttt tcctatctct tgattttatt gttgttgtta ttgctattgt
     6061 tattattatt attcgtgatc tttatttcga tgaggggttg ggaagtggga gggagtcgaa
     6121 ctgagactag gggttgagag gatttttttg gtttggtttt cttttctttt ttttttgttt
     6181 tttttttttt ttgtttgttt gtttcatctt tgcgtccaac aggcagaata tggtctgtgt
     6241 ccaaaacgga acttaagtca ggaaggaaac cattcagcgt aaacaagcac aacatgtagt
     6301 ctgtcggctg tctggaagca aaaataaatt aataaataaa taataaataa gtaaaagaca
     6361 cacacggagg tgaagatgaa atgtgatgga ttccgagaca atggggcacc aaggcctgta
     6421 ggcctcctct tgattttgct ttggttatgt ttgttttcct tagagatgtt tttttcctca
     6481 cgggacttga agtgactcat ctctgtgcag taatggtttc gccatatgct catttcaagt
     6541 attatagaca tatgtaatgg tgaaatatat gaactgtggc ctttttcatt cttgttattt
     6601 gtgatgcaat taagtgaaga gaagaaaaaa aaaagcagag atttaccatg tatcagtgcc
     6661 tggctttttg ttataaagct tcgtctgtct agtgctcttt ttgctataaa aatagactgt
     6721 agtacaccct agtaggaaaa aaaaacccta aatttaaaaa taaaaaaata tatttggctt
     6781 atttttcgca ggagcaatcc ttttatacca tggatattac aaaaaaaaaa attgtcagat
     6841 tctgaatatt tcttctttgt agatttttgg aatcattata agtaaaagtt tgttacttta
     6901 ttttactatt taaaagatgt tattttgcca tgtgttactg agatgaaact gtatggtata
     6961 gcttcttctg ttcgtttttt gtttccggtt ttttgtttgt tcgtttttgg tttttttttt
     7021 ttttgtttgt ttgttttgtt ttgttttttt ttcttagttg taggtcgcag taaggacttt
     7081 tccttttgtt tttgtttttt cgttatgttt tgttttgttt ttgcgactgt acacatagct
     7141 gcagcattaa aaacttttaa aaaaatctgt taaaaaaaaa agaaaaaaaa gggaaaacgt
     7201 ttaaaaaaaa aagataaaca gttacacctt gttttcaacg tgtggctgag tgcctcgatt
     7261 ttttcatgtt tttggtgtat ttctgatttg tagaagtgtc caaacaggtt gtgtcctgga
     7321 cttccttcaa gaggcgaaca acccagcttg gtctaggcca tgacctgttc ccatctgtag
     7381 ttactcgatg aagtcatgta catgaccgtt ctgtagcaat aaatgtgcca tttttataaa
//
LOCUS       NM_001437052            4975 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus RNA binding motif protein 47 (Rbm47), transcript
            variant 2, mRNA.
ACCESSION   NM_001437052 XM_063273126
VERSION     NM_001437052.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063273126.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2641049.1,
                                           SRR26643294.49972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000014.1  42408306-42408711
            407-487             JAXUCZ010000014.1  42466335-42466415
            488-607             JAXUCZ010000014.1  42515618-42515737
            608-1767            JAXUCZ010000014.1  42535100-42536259
            1768-1974           JAXUCZ010000014.1  42537071-42537277
            1975-2180           JAXUCZ010000014.1  42539399-42539604
            2181-4975           JAXUCZ010000014.1  42542510-42545304
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4975
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="RNA binding motif protein 47"
                     /db_xref="GeneID:305340"
                     /db_xref="RGD:1359713"
     exon            1..406
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            407..487
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            488..607
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    516..518
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="upstream in-frame stop codon"
     exon            608..1767
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     CDS             639..2411
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="hypothetical RNA binding protein RGD1359713"
                     /codon_start=1
                     /product="RNA-binding protein 47"
                     /protein_id="NP_001423981.1"
                     /db_xref="GeneID:305340"
                     /db_xref="RGD:1359713"
                     /translation="MTAEDSTTAMNSDPTVGSSTKVPEGVAGAPNEAALLALMERTGY
                     NMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRL
                     MMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPK
                     MKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGR
                     IQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKRSFGQFNPGCVER
                     VKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGG
                     GGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRT
                     PGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISAVNPVAIKPGTVAIPA
                     IGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVS
                     TPPPFQGRPITPVYTVAPNVPRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGG
                     YAGYIPQAFPAALQVPIHDVYQTY"
     misc_feature    639..716
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H68.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    669..2408
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    669..2408
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    1824..1826
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96; propagated from
                     UniProtKB/Swiss-Prot (Q66H68.1); methylation site"
     misc_feature    1857..1859
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96; propagated from
                     UniProtKB/Swiss-Prot (Q66H68.1); methylation site"
     exon            1768..1974
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2180
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..4975
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccggac tccgccgcgc tccccgggat ccgaccccgt gccgctccgc ccgggccgca
       61 gctgccccgc agcccgctcg tactacccag cctagccggt cgccgagctc cgggacccgg
      121 agaagctagg ctctgggtcc gggggaagtt tctctccgct ggtcgctcag gttaagaaat
      181 tgtgacaaac tggaattccc agagcctggg agagttaaag cctagagcga tctgttgctt
      241 taagccgcac ggtgggaagt agcttggaga ctctttaatt tggttttcta tttaaaagag
      301 ggcggccagc gaagatgttg taggtgactt cctagccttg tagattgcta ccgggctgtg
      361 aatggtatta atttctgaag tgggcgacgc caagtactta cggaagctca ggtaacaaac
      421 aagttagaag gacagcctgc gccctgccac ccagcctcac tagcagctcc cagctcactg
      481 aagtttgggt ttgcctcaaa gaatacttca agaactgaac agagaaatcc caagtgagct
      541 gcctgaatct tcgcgaattc tcttgttcta ccttccatag aaagaccaat caaattgctg
      601 acttttggtt tcctccagct gtggatgcct ttgacattat gactgcagaa gattccacca
      661 cagccatgaa cagcgatcca acagtggggt cctccaccaa ggtaccggag ggtgtggcgg
      721 gcgcgcccaa tgaggctgca ctgttggcac tgatggagcg caccggttac aacatggtac
      781 aggagaatgg gcagcgcaag tatggtggac ccccgcccgg ctgggagggc ccgcatcccc
      841 agcgtggctg tgaggtcttc gtgggcaaga tcccacgtga tgtgtatgaa gatgagctgg
      901 tgcctgtgtt tgagacggta ggtcgcatct acgagctgcg cctcatgatg gatttcgatg
      961 gcaagaaccg cggctatgcc ttcgtgatgt actgccacaa gcacgaggcc aagcgagctg
     1021 tccgtgagct caacaactat gagatccgcc cgggtcgtct gctgggagtg tgctgcagtg
     1081 tggacaactg ccgcctcttc atcggtggca tccccaagat gaagaagcgt ggggagatcc
     1141 tggaggagat cgccaaggtc accgagggcg tgctcaacgt gattgtgtat gccagtgcag
     1201 cagacaagat gaaaaaccga ggcttcgcct ttgtggaata tgagagccat cgggccgcag
     1261 caatggcccg tcgcaagctc atgccgggtc gtatccagct gtggggccac cagatagccg
     1321 tggactgggc cgagccagag attgatgtag atgaggatgt gatgcagacc gtgaagatcc
     1381 tctacgtgcg caacctcatg atcgagacca ccgaggagac catcaagagg agctttggcc
     1441 agttcaaccc aggctgtgtg gaaagagtca agaagatccg tgactacgcc ttcgtgcact
     1501 tcactagccg cgaggacgct gtgcacgcta tgaacaacct caatggcaca gagctggagg
     1561 gctcctgctt agaagtcacg ctggccaagc ctgtggacaa ggagcagtac tctcgctacc
     1621 agaaggcagc caagggtggc ggtggctcag ctgaggcagt ggcacaacag cccagctacg
     1681 tgtactcctg tgacccctac acgctggcct attatggcta cccctacaac gcgctcatcg
     1741 ggcccaaccg ggactacttc gtgaaaacag gcagcataag aggccgagga cgcggtgcag
     1801 ctgggaacag aaccccgggg cccaggggtt cctacctggg agggtattct gccggccgtg
     1861 gcatatatag ccgatatcac gaaggcaagg gcaaacagca ggagaaagga tacgagctcg
     1921 tgccgaacct ggaaatctct gccgtcaacc cagtggccat caaacctggc acagtggcca
     1981 tccctgccat tggtgcccag tactccatgt tccaggcagc cccggcccct aaaataattg
     2041 aagatggcaa gatccacaca atggaacaca tgatcagccc cattgcggtg cagccagacc
     2101 cggccactgc tgctgccgcc gccgctgccg ctgctgctgc tgctgtcatt cctgcggtat
     2161 ccacaccgcc gcctttccag ggccgtccaa taactcctgt gtacactgtg gcaccaaatg
     2221 ttccgagaat ccccaccgcc ggcatctacg gggccagcta tgtccccttt gctgctccgg
     2281 ccactgccac aatcgccaca ctacagaaga acgctgcagc cgccgtgtac gggggctacg
     2341 cgggctacat acctcaggcc ttccctgctg ctctccaggt gcccatccac gacgtctacc
     2401 agacttactg agaccgggga ccagaaaggc aagccaccaa accccgccga aggaacactc
     2461 tattatttat gaagaaagaa cgtgtcgggt tgacacacgt gtaaaacctg caagtgaaga
     2521 agaatgttat caaatagcac actgaaatat tttatatcca tgaagttttc actcatgttt
     2581 ttttgaaaat gacttttcaa tttagcaggc ccgcgttcat acatttctaa gagacttgcg
     2641 acgcctcatg ccttaacatc atcttttaaa gtttgtatgc tctactgtgt ttgtacagag
     2701 gtttggtttt gttttttaag gatatatttt cagtatgaag gttattttct taacttctgc
     2761 actccagagt tttctatttt gtagaacctt tcaaaatata tcagctctct ctatatatat
     2821 gtatatgtat atccaaaaaa aaaaaaaaaa agagcacgcc cgggcatcta gggaactatt
     2881 ttgaaaacta tattcaatat ttaaagacac aaactgtagt gttctgaaat gctacgcaaa
     2941 acattttatt tttaaggtga tgctggaaag tgcaatttta aaatgaggaa aaaaaggtct
     3001 ctactgtgtt tctactggca ttaagggttg acgatattgc catatattct tgtcatgttt
     3061 tctgggttta tgggggtttg ggtttggttt gtttgtttgt ttgtttgttt taataagtct
     3121 gttcttaagc caacatggaa aagactcccc acacccagag tcccaacact ggaaagctct
     3181 gacctgccct cagtaccctg ggctcaccct gtgtctctac tgttatctgc cccgccccac
     3241 cctcaaggag ggattctgcc tccttccctg gctcccgggc agctctgagg tttggcatat
     3301 ctaagaaaag tggataatcg aatggagagg actactgatg ccttttatgc ttcttcctgg
     3361 gattgtgttg gggtcttttt atatttaatt ttggattgtc tggggatgta ttttcttctc
     3421 catgtgtttt cagtagcaga atgcacccga gggcaagatt ttacctcgtt tgcctaaggc
     3481 atctttgcat agctatttgt tcagtacgga acttcaactt tctaatcctt tgtttttttg
     3541 gcgtgttttt ttttttttta agtctgagtt tttagagacc aagaatgtat gtgactatag
     3601 acaagacctt caagacttgt caacaggaag tttagcttct cgctgccttt ctgcgtttcc
     3661 tacaggatgc ctgttgtcat cagggatgtt agaagcactg tgtgtgttta acagggtttc
     3721 tctcagccgc cctgcgtttg gtaggcgaac agggggcata cccatccaag aggaggacct
     3781 gtaggttaag ggtagtttgt aaataacttc tgatgcttgc tcatacacac cttctgtgtt
     3841 gccaaagctc gtggcttgta gtgtaatgcg aaacgcagcc attttatttc aatgttatta
     3901 aaagtgtttg cttttttgtg ggggggggag taaatgcaca gaggcagggt tagggttttg
     3961 tgcctgtttt aaggctttta tttggcagtg aatgtaaaat acagtgaaat gataatattg
     4021 tcatctcttt tatgaattac atctttttaa aaggcttggt ccagggtgtg aagtgagcga
     4081 taaggtaaca gaggcatggt tgtattttat ggcataacag agtccatcag atttttcttc
     4141 cctccagagt tttgctaata ggcttaactc ttatttctgg attaatagta ggatcatgcc
     4201 cttagcaaat aattttctgt ttttaaatta agagattccc aaatgtcttt tccccccctt
     4261 atcttgatgg gatggatttt atatataaga aatatttatt tagctattct gtaaaattat
     4321 ctagtgcctg ctaaggcctt tgagcatccc tccatcctgt tgcgtggcat aaagcagcag
     4381 ctgtacggtg ttctgggggc tcactcagaa gctgcaccca ctcgggcccg tggggatgag
     4441 ggaccttatc aaaggtatca ggttctcatc ccttgacttg tgtgaggaaa aaagtgcttt
     4501 ccttcctgcc accacggact gacatggaag tcttcagatg gaacgctgac cccatgttct
     4561 tactgtattt ttcaagtgcc tggaaaaaaa tattttcaaa aacaatacta gtaataataa
     4621 aaggaaaaaa tatgcactaa cttaacatgg caactacctt aacaacaggc attggtggca
     4681 gccagttaag caccagtggc cctgctgtct gtgatcttac ctgttcctct tgtttctcaa
     4741 ccatttcaca cgtacactac tgaggtaagt ttataacttg aaatgtgaac tttttttttt
     4801 tttaggaata agaacaaact aatataaatg tttttaaacg ttttagagtt tgggttttag
     4861 acatgctact agtttagttt ttagcttcat atttgaaaag ctttttagat ctcgcttcat
     4921 ttacatacag tgcattctta aaatgtatgt ggtaaataaa gctttcttga aagca
//
LOCUS       NM_053369               7136 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            1, mRNA.
ACCESSION   NM_053369 XM_063277620
VERSION     NM_053369.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Mar 26, 2025 this sequence version replaced
            XM_063277620.1, NM_053369.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000018.1  65218587-65218749
            164-255             JAXUCZ010000018.1  65219645-65219736
            256-328             JAXUCZ010000018.1  65221421-65221493
            329-390             JAXUCZ010000018.1  65334541-65334602
            391-487             JAXUCZ010000018.1  65337982-65338078
            488-549             JAXUCZ010000018.1  65391770-65391831
            550-676             JAXUCZ010000018.1  65437942-65438068
            677-726             JAXUCZ010000018.1  65438528-65438577
            727-832             JAXUCZ010000018.1  65507173-65507278
            833-963             JAXUCZ010000018.1  65511025-65511155
            964-1096            JAXUCZ010000018.1  65516916-65517048
            1097-1164           JAXUCZ010000018.1  65525175-65525242
            1165-1243           JAXUCZ010000018.1  65526319-65526397
            1244-1320           JAXUCZ010000018.1  65528841-65528917
            1321-1524           JAXUCZ010000018.1  65531547-65531750
            1525-1660           JAXUCZ010000018.1  65551334-65551469
            1661-1811           JAXUCZ010000018.1  65553405-65553555
            1812-2041           JAXUCZ010000018.1  65556812-65557041
            2042-2182           JAXUCZ010000018.1  65557878-65558018
            2183-7136           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7136
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..163
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            164..255
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2178
                     /gene="Tcf4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 1"
                     /protein_id="NP_445821.2"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLH
                     SSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDG
                     HHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPP
                     MSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHT
                     NNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDD
                     AIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGA
                     HREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSS
                     EIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMAN
                     NARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLN
                     PKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    424..>1068
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    424..>1068
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1846..2100
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1846..2100
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1870..1872,1882..1884,1888..1896,1900..1902,
                     1915..1917,1978..1983)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1870..1872,1882..1884,1888..1896,1900..1902,
                     1915..1917,1978..1983)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1909..1914,1921..1926,1930..1935,1942..1944,
                     1954..1956,1984..1986,1993..1995,2005..2007,2014..2016,
                     2023..2040)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1909..1914,1921..1926,1930..1935,1942..1944,
                     1954..1956,1984..1986,1993..1995,2005..2007,2014..2016,
                     2023..2040)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            256..328
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..390
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..676
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            677..726
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            727..832
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            833..963
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1096
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1164
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1243
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1320
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1524
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1660
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1811
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2041
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2182
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..7136
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcgg atcggcggcg gcggcggcgg cggcggcggg gaagccggag cgggcgcggg
       61 cgccggccgt tggaggaggt ggtggtggcg gaggcagggg gatagacatg accgccgcct
      121 gggcgccggc gctgcaccgg gagcccctcg tcgcgcgcgg gcggtttgtg tgattttgct
      181 aaaatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct gagtgattta
      241 ctggatttca gtgcgatgtt ttcgcctcct gtaagcagtg ggaaaaatgg accaacttct
      301 ttggcgagtg gacattttac gggctcaaat gtagaagaca gaagtagctc agggtcctgg
      361 gggaatggag gtcatccaag cccgtccagg aactatggag atgggactcc ctatgaccac
      421 atgactagca gggatcttgg gtcacatgac aatctctctc caccttttgt caattccaga
      481 atacaaagta aaacagaaag gggttcatac tcatcttatg ggagagaaaa cgtacagggt
      541 tgccaccaga gtctcctcgg aggggacatg gatatgggca acccaggaac cctttcgccc
      601 accaaacctg gctcccagta ctacccatat tccagcaata acgcccgacg gaggcctctt
      661 cacagtagta ccatggaggt gcagacaaag aaagtcagaa aagttcctcc aggcttgcca
      721 tcttcagtct acgctccttc agccagcact gccgactaca acagggactc accaggctat
      781 tcttcctcca agccagcagc cagcactttc tccagctcct tcttcatgca agatggccat
      841 cacagcagtg acccttggag ctcctccagt ggaatgaatc agcccggcta tggagggatg
      901 ctaggcaact ctcatatccc acagtctagc agctactgta gcctgcatcc acatgaacgt
      961 ctgagctatc catcgcactc ctcggcagac atcaactcca gtcttcctcc gatgtccacg
     1021 ttccatcgaa gtggcacaaa ccattacagc acctcttcct gcacacctcc tgccaacgga
     1081 acagacagta taatggcaaa cagaggaact ggggcagcag gcagctccca gactggagac
     1141 gctctgggga aagccctggc ttcgatctat tctcctgatc acacgaacaa cagcttctcc
     1201 tccaaccctt caactcctgt tggctcccct ccttcactct cagcaggcac agctgtttgg
     1261 tctcgaaacg gaggacaggc ctcgtcatct cccaattacg aaggaccctt gcactccttg
     1321 cagagccgaa ttgaagaccg tttagaaaga ctggacgacg cgattcatgt tctccggaac
     1381 cacgcggtgg gcccatccac agctgtgccc ggtggccatg gggacatgca tgggatcatc
     1441 ggaccctctc acaatggagc aatgggcagt ctgggctcag gatatggaac tggccttctc
     1501 tcagccaaca gacattcact catggtcggg gcccaccgtg aagatggcgt ggcactgaga
     1561 ggcagccatt ctctcctgcc aaaccaggtt ccggttccac agcttccagt ccagtctgca
     1621 acttcccctg acttgaaccc accccaagac ccttacagag ggatgccacc aggcctccag
     1681 ggacagagtg tgtcttccgg cagctctgag atcaagtccg acgacgaggg cgatgagaac
     1741 ctacaggaca caaaatcttc cgaggacaag aaactagacg acgacaagaa ggatatcaaa
     1801 tcaattacta gcaataacga tgatgaggac ctgaccccgg agcagaaggc cgagcgtgag
     1861 aaggagcgga ggatggccaa taacgcccgt gagcgcctga gggtccgtga tatcaacgag
     1921 gctttcaagg agctgggccg catggtacag ctccacctga agagcgacaa gccccagacc
     1981 aagctcctga ttctccacca ggcagtggct gtcatcctca gcctggagca gcaagtgcga
     2041 gaaaggaacc tgaacccaaa agctgcctgt ctgaaaagaa gggaggaaga gaaggtgtcc
     2101 tcagagcctc ccccgctctc cttggctggc ccacaccctg ggatgggaga cgcagcgaat
     2161 cacatgggtc agatgtgaaa gggtccaagt tgccaccttg cttcattaaa acaagagacc
     2221 acttccttaa cagctgtatt atcctaaacc cacataaaca ctgctcctta accccgtttt
     2281 ttttgtaata taagacaagt ctgagtagtt atgaatcgca gacgcaagag gtttcagcat
     2341 tcccaattat caaaaaacag aaaaacaaac acaaaaaaaa aatgaatgaa agaaagaaag
     2401 aaagagaaaa tgcaacttga gggacgactt ctttaacata tcactctgaa tgtgcgaagc
     2461 ggtatgtaca ggctgagacg cagcccagag actgaatggc aatccttcca cactgtggag
     2521 caatgcattt gtgcctaaac ttcttttgga aaaaaaaata taattaattt gtaagtctga
     2581 aaaaaaatat ttaatttaaa aaaaattgta aacttgcaat aatgaaaaag tgtacttctg
     2641 aagaaaaacg acatgaacgt ttttgttggt attcaagtca gctagtgttt ctaattaccg
     2701 gatattgaat agaggaagcc cggctaccct cataacaaaa ccagcaaccg tcctgatggc
     2761 aaccgaaatg atgacattag ccattcctta gggtaggagg gacagatgga tgttatagac
     2821 ctatgacaaa tatatatata aatatatata taaatatata ttaaaaattt agtgactatg
     2881 gtaagctttt gttcatttgt ttcagacttt tttctcctgt aaaaaaatag tactgattaa
     2941 cttttttaaa agaaagattt tactgtaaat atggattttt ttttgtctga tttttgtccc
     3001 ttcccccagt ttgttatcgt gacctgtagt gccaactctg cttccggagg ggcagtgcag
     3061 gacgaaatgc tgaccctgat gttgcttctc attcataaat agtagaaagt tgtttctcca
     3121 gtcttttggg aacacaggac ttaaaagtca catcatgtgt agaaattaca tgcagcattg
     3181 cccgggcaag gcaaaaagag tttgtctggc ttgtggcact gtgcttgtta ccctctcctg
     3241 ggattttcag aggtacacgg ttagaatgct acaatgttac cactgtgcct tccaatgttt
     3301 atatcatcgg aaacatgaca taatcaaagt ggctgtgatt taacaaaaaa aaaaaaagat
     3361 tcaagtgtta cctacctgtg tagcggaagt agtgtgcagt gagacgtttc tgaatacatg
     3421 gtcagatttt ttttggaaaa aatacaaaaa caaaaaaaaa aaacaaaaaa atttaaaaaa
     3481 aaaagtcaag ttcaaaaacc gtcaaatgag aaaatcgcaa ggagtgtgac agctgattga
     3541 ttttgttgct tttcttgatt tttttttttt tgtttccaaa tgggtttact aaaaagtaca
     3601 tgacttacct gcctcctcct tcgtctgaaa acaaaaaaca aaaaaacaat gccaacctat
     3661 cccacagcat tatagcaagc cttataagcc ctaaagcatt aagttgcact ttggtgagga
     3721 ggggtagcgc agtattctct ctggccagta tgagtgaagt ttatacttaa catttgatag
     3781 aaacatagat caaactgtgg cacagtaact catcagatag ctagcgttga ctctgggcac
     3841 aattgaacca attcccatcc taaatctttc caacaattga ctttggtgta cagtgcagtg
     3901 aacacataga actcctactt aagtattcgt cagcatcctt ttgtctctaa ctcggttctg
     3961 ttttgacagc cacacaatct tggcatgtat taagtaaaaa aaaaaaaaaa atccctgttg
     4021 aagtagtttt cccacctatc agcactgagt aattgccgta actcaatgga aatggtctaa
     4081 acgcccccca tctcttgtcc tgtaccacca gttacacagt gacaaaacac atctgtaaat
     4141 tttatgcaac caatggcaaa cctatcatta ttttgaaact gtgtatgtaa aagttatatt
     4201 tttacatgta gactcttgtt attatgtgtt ttaatacatt gtatcagttt tttgtttcct
     4261 ttttttttta actgtgtggt tttaaaaagt catttaaatg aaatagcgag ctacaagaat
     4321 ctgaaattta tgttcatttc tgaaaatgta agaacaaata agatagttat cacgtggtca
     4381 ccttttacaa acccatcgat gttttgacta gctgtgtgta tgtgtgtgtg tgcgcatgtg
     4441 tgcgtgtgtg tgtatgtgtg ttgaaaactg taaatatgtt cagtagcgat aaaacgacaa
     4501 tgctttgatt tgttgagaag ttcctaaaat gtggaggtgg attgaaaatg taggggaata
     4561 gcagaaatca gatttcatga agagctcttc tcttcggggg ctttcctgtg gaatggtcaa
     4621 acagaggtgc tccaagaagg gcaaggaaga cagtaacttc ccctcctccc tgaacgacgg
     4681 aaaccatgtg tacgtggtct ctcaccatgt taaagatttt ctttccgtga tacattctgc
     4741 actctttttg tatagtctac caaggcgggt atccctggga acaatattat gatataggaa
     4801 gcagtatact ctgatcacat tcaggagaat tgtatagaag agaatatggt gtttactctt
     4861 tagggaactg gaaattctcc ctgcattgat gtacatcttc agagcggccc ttttgataca
     4921 cgttatcata aaggtgctga ctaaagcaga attaaagttt ttcaaatctg taaacaaagc
     4981 aaaaaattaa attacagtca ttcgattgtt tgtttttttt tttttccaat tggtgctttt
     5041 atattttgtt ctcactcaga cagaaaaggc tgcaatttct tgttcaccag ctttgatgta
     5101 ttcattactc ggtaatgtaa tacggctatt gtcaaattcc ttttggaaat aagcaaaagg
     5161 cttccccaag gcctgcagca gctgctggct actttctgct tggcgcagaa acatgatctg
     5221 accctctctg tagtaatcga gttgtatctc cagttttaaa aagaaggaaa aagggaatgt
     5281 ggccgtttta atgtgttttt ttttttcttt tcttgttgtt attttgtaat tctcaaaccc
     5341 aggtaagata ttggtattcc tgcactggat ttttgaaaga aacttagcag aagacaggat
     5401 cgagatacta tagaagcatt tcccaagtgt tcatactata ctagacataa atgataacgg
     5461 cgatgtatag gttcaggatc ggtttaagag actcagactt tgaaagcaac ttggaacggt
     5521 tgatccacct ccacattcga gtaattaata attctgcaga attagggatc tgtccatcta
     5581 ggagttgtta cccatttgtc ttctgtgtgg ctgcgaggaa cactaacgct tttacaactg
     5641 tcagttcacc cagtggtaca actgattctg actcagtctt ccgattcctg ttttgtattt
     5701 tgtttttcca cttttttcct atctcttgat tttattgttg ttgttattgc tattgttatt
     5761 attattattc gtgatcttta tttcgatgag gggttgggaa gtgggaggga gtcgaactga
     5821 gactaggggt tgagaggatt tttttggttt ggttttcttt tctttttttt ttgttttttt
     5881 ttttttttgt ttgtttgttt catctttgcg tccaacaggc agaatatggt ctgtgtccaa
     5941 aacggaactt aagtcaggaa ggaaaccatt cagcgtaaac aagcacaaca tgtagtctgt
     6001 cggctgtctg gaagcaaaaa taaattaata aataaataat aaataagtaa aagacacaca
     6061 cggaggtgaa gatgaaatgt gatggattcc gagacaatgg ggcaccaagg cctgtaggcc
     6121 tcctcttgat tttgctttgg ttatgtttgt tttccttaga gatgtttttt tcctcacggg
     6181 acttgaagtg actcatctct gtgcagtaat ggtttcgcca tatgctcatt tcaagtatta
     6241 tagacatatg taatggtgaa atatatgaac tgtggccttt ttcattcttg ttatttgtga
     6301 tgcaattaag tgaagagaag aaaaaaaaaa gcagagattt accatgtatc agtgcctggc
     6361 tttttgttat aaagcttcgt ctgtctagtg ctctttttgc tataaaaata gactgtagta
     6421 caccctagta ggaaaaaaaa accctaaatt taaaaataaa aaaatatatt tggcttattt
     6481 ttcgcaggag caatcctttt ataccatgga tattacaaaa aaaaaaattg tcagattctg
     6541 aatatttctt ctttgtagat ttttggaatc attataagta aaagtttgtt actttatttt
     6601 actatttaaa agatgttatt ttgccatgtg ttactgagat gaaactgtat ggtatagctt
     6661 cttctgttcg ttttttgttt ccggtttttt gtttgttcgt ttttggtttt tttttttttt
     6721 gtttgtttgt tttgttttgt ttttttttct tagttgtagg tcgcagtaag gacttttcct
     6781 tttgtttttg ttttttcgtt atgttttgtt ttgtttttgc gactgtacac atagctgcag
     6841 cattaaaaac ttttaaaaaa atctgttaaa aaaaaaagaa aaaaaaggga aaacgtttaa
     6901 aaaaaaaaga taaacagtta caccttgttt tcaacgtgtg gctgagtgcc tcgatttttt
     6961 catgtttttg gtgtatttct gatttgtaga agtgtccaaa caggttgtgt cctggacttc
     7021 cttcaagagg cgaacaaccc agcttggtct aggccatgac ctgttcccat ctgtagttac
     7081 tcgatgaagt catgtacatg accgttctgt agcaataaat gtgccatttt tataaa
//
LOCUS       NM_001437093            6579 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            18, mRNA.
ACCESSION   NM_001437093 XM_063277630
VERSION     NM_001437093.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6579)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6579)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6579)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6579)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6579)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6579)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6579)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6579)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6579)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6579)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277630.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.177477.1,
                                           SRR26360172.1400247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-766             JAXUCZ010000018.1  65528841-65528917
            767-967             JAXUCZ010000018.1  65531550-65531750
            968-1103            JAXUCZ010000018.1  65551334-65551469
            1104-1254           JAXUCZ010000018.1  65553405-65553555
            1255-1484           JAXUCZ010000018.1  65556812-65557041
            1485-1625           JAXUCZ010000018.1  65557878-65558018
            1626-6579           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6579
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1621
                     /gene="Tcf4"
                     /note="isoform 18 is encoded by transcript variant 18;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 18"
                     /protein_id="NP_001424022.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPL
                     HSLSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYG
                     TGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRG
                     MPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLT
                     PEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVA
                     VILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    1289..1543
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1289..1543
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1313..1315,1325..1327,1331..1339,1343..1345,
                     1358..1360,1421..1426)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1313..1315,1325..1327,1331..1339,1343..1345,
                     1358..1360,1421..1426)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1352..1357,1364..1369,1373..1378,1385..1387,
                     1397..1399,1427..1429,1436..1438,1448..1450,1457..1459,
                     1466..1483)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1352..1357,1364..1369,1373..1378,1385..1387,
                     1397..1399,1427..1429,1436..1438,1448..1450,1457..1459,
                     1466..1483)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..766
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1254
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1484
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1625
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..6579
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagc aggcacagct gtttggtctc gaaacggagg
      721 acaggcctcg tcatctccca attacgaagg acccttgcac tccttgagcc gaattgaaga
      781 ccgtttagaa agactggacg acgcgattca tgttctccgg aaccacgcgg tgggcccatc
      841 cacagctgtg cccggtggcc atggggacat gcatgggatc atcggaccct ctcacaatgg
      901 agcaatgggc agtctgggct caggatatgg aactggcctt ctctcagcca acagacattc
      961 actcatggtc ggggcccacc gtgaagatgg cgtggcactg agaggcagcc attctctcct
     1021 gccaaaccag gttccggttc cacagcttcc agtccagtct gcaacttccc ctgacttgaa
     1081 cccaccccaa gacccttaca gagggatgcc accaggcctc cagggacaga gtgtgtcttc
     1141 cggcagctct gagatcaagt ccgacgacga gggcgatgag aacctacagg acacaaaatc
     1201 ttccgaggac aagaaactag acgacgacaa gaaggatatc aaatcaatta ctagcaataa
     1261 cgatgatgag gacctgaccc cggagcagaa ggccgagcgt gagaaggagc ggaggatggc
     1321 caataacgcc cgtgagcgcc tgagggtccg tgatatcaac gaggctttca aggagctggg
     1381 ccgcatggta cagctccacc tgaagagcga caagccccag accaagctcc tgattctcca
     1441 ccaggcagtg gctgtcatcc tcagcctgga gcagcaagtg cgagaaagga acctgaaccc
     1501 aaaagctgcc tgtctgaaaa gaagggagga agagaaggtg tcctcagagc ctcccccgct
     1561 ctccttggct ggcccacacc ctgggatggg agacgcagcg aatcacatgg gtcagatgtg
     1621 aaagggtcca agttgccacc ttgcttcatt aaaacaagag accacttcct taacagctgt
     1681 attatcctaa acccacataa acactgctcc ttaaccccgt tttttttgta atataagaca
     1741 agtctgagta gttatgaatc gcagacgcaa gaggtttcag cattcccaat tatcaaaaaa
     1801 cagaaaaaca aacacaaaaa aaaaatgaat gaaagaaaga aagaaagaga aaatgcaact
     1861 tgagggacga cttctttaac atatcactct gaatgtgcga agcggtatgt acaggctgag
     1921 acgcagccca gagactgaat ggcaatcctt ccacactgtg gagcaatgca tttgtgccta
     1981 aacttctttt ggaaaaaaaa atataattaa tttgtaagtc tgaaaaaaaa tatttaattt
     2041 aaaaaaaatt gtaaacttgc aataatgaaa aagtgtactt ctgaagaaaa acgacatgaa
     2101 cgtttttgtt ggtattcaag tcagctagtg tttctaatta ccggatattg aatagaggaa
     2161 gcccggctac cctcataaca aaaccagcaa ccgtcctgat ggcaaccgaa atgatgacat
     2221 tagccattcc ttagggtagg agggacagat ggatgttata gacctatgac aaatatatat
     2281 ataaatatat atataaatat atattaaaaa tttagtgact atggtaagct tttgttcatt
     2341 tgtttcagac ttttttctcc tgtaaaaaaa tagtactgat taactttttt aaaagaaaga
     2401 ttttactgta aatatggatt tttttttgtc tgatttttgt cccttccccc agtttgttat
     2461 cgtgacctgt agtgccaact ctgcttccgg aggggcagtg caggacgaaa tgctgaccct
     2521 gatgttgctt ctcattcata aatagtagaa agttgtttct ccagtctttt gggaacacag
     2581 gacttaaaag tcacatcatg tgtagaaatt acatgcagca ttgcccgggc aaggcaaaaa
     2641 gagtttgtct ggcttgtggc actgtgcttg ttaccctctc ctgggatttt cagaggtaca
     2701 cggttagaat gctacaatgt taccactgtg ccttccaatg tttatatcat cggaaacatg
     2761 acataatcaa agtggctgtg atttaacaaa aaaaaaaaaa gattcaagtg ttacctacct
     2821 gtgtagcgga agtagtgtgc agtgagacgt ttctgaatac atggtcagat tttttttgga
     2881 aaaaatacaa aaacaaaaaa aaaaaacaaa aaaatttaaa aaaaaaagtc aagttcaaaa
     2941 accgtcaaat gagaaaatcg caaggagtgt gacagctgat tgattttgtt gcttttcttg
     3001 attttttttt ttttgtttcc aaatgggttt actaaaaagt acatgactta cctgcctcct
     3061 ccttcgtctg aaaacaaaaa acaaaaaaac aatgccaacc tatcccacag cattatagca
     3121 agccttataa gccctaaagc attaagttgc actttggtga ggaggggtag cgcagtattc
     3181 tctctggcca gtatgagtga agtttatact taacatttga tagaaacata gatcaaactg
     3241 tggcacagta actcatcaga tagctagcgt tgactctggg cacaattgaa ccaattccca
     3301 tcctaaatct ttccaacaat tgactttggt gtacagtgca gtgaacacat agaactccta
     3361 cttaagtatt cgtcagcatc cttttgtctc taactcggtt ctgttttgac agccacacaa
     3421 tcttggcatg tattaagtaa aaaaaaaaaa aaaatccctg ttgaagtagt tttcccacct
     3481 atcagcactg agtaattgcc gtaactcaat ggaaatggtc taaacgcccc ccatctcttg
     3541 tcctgtacca ccagttacac agtgacaaaa cacatctgta aattttatgc aaccaatggc
     3601 aaacctatca ttattttgaa actgtgtatg taaaagttat atttttacat gtagactctt
     3661 gttattatgt gttttaatac attgtatcag ttttttgttt cctttttttt ttaactgtgt
     3721 ggttttaaaa agtcatttaa atgaaatagc gagctacaag aatctgaaat ttatgttcat
     3781 ttctgaaaat gtaagaacaa ataagatagt tatcacgtgg tcacctttta caaacccatc
     3841 gatgttttga ctagctgtgt gtatgtgtgt gtgtgcgcat gtgtgcgtgt gtgtgtatgt
     3901 gtgttgaaaa ctgtaaatat gttcagtagc gataaaacga caatgctttg atttgttgag
     3961 aagttcctaa aatgtggagg tggattgaaa atgtagggga atagcagaaa tcagatttca
     4021 tgaagagctc ttctcttcgg gggctttcct gtggaatggt caaacagagg tgctccaaga
     4081 agggcaagga agacagtaac ttcccctcct ccctgaacga cggaaaccat gtgtacgtgg
     4141 tctctcacca tgttaaagat tttctttccg tgatacattc tgcactcttt ttgtatagtc
     4201 taccaaggcg ggtatccctg ggaacaatat tatgatatag gaagcagtat actctgatca
     4261 cattcaggag aattgtatag aagagaatat ggtgtttact ctttagggaa ctggaaattc
     4321 tccctgcatt gatgtacatc ttcagagcgg cccttttgat acacgttatc ataaaggtgc
     4381 tgactaaagc agaattaaag tttttcaaat ctgtaaacaa agcaaaaaat taaattacag
     4441 tcattcgatt gtttgttttt ttttttttcc aattggtgct tttatatttt gttctcactc
     4501 agacagaaaa ggctgcaatt tcttgttcac cagctttgat gtattcatta ctcggtaatg
     4561 taatacggct attgtcaaat tccttttgga aataagcaaa aggcttcccc aaggcctgca
     4621 gcagctgctg gctactttct gcttggcgca gaaacatgat ctgaccctct ctgtagtaat
     4681 cgagttgtat ctccagtttt aaaaagaagg aaaaagggaa tgtggccgtt ttaatgtgtt
     4741 tttttttttc ttttcttgtt gttattttgt aattctcaaa cccaggtaag atattggtat
     4801 tcctgcactg gatttttgaa agaaacttag cagaagacag gatcgagata ctatagaagc
     4861 atttcccaag tgttcatact atactagaca taaatgataa cggcgatgta taggttcagg
     4921 atcggtttaa gagactcaga ctttgaaagc aacttggaac ggttgatcca cctccacatt
     4981 cgagtaatta ataattctgc agaattaggg atctgtccat ctaggagttg ttacccattt
     5041 gtcttctgtg tggctgcgag gaacactaac gcttttacaa ctgtcagttc acccagtggt
     5101 acaactgatt ctgactcagt cttccgattc ctgttttgta ttttgttttt ccactttttt
     5161 cctatctctt gattttattg ttgttgttat tgctattgtt attattatta ttcgtgatct
     5221 ttatttcgat gaggggttgg gaagtgggag ggagtcgaac tgagactagg ggttgagagg
     5281 atttttttgg tttggttttc ttttcttttt tttttgtttt tttttttttt tgtttgtttg
     5341 tttcatcttt gcgtccaaca ggcagaatat ggtctgtgtc caaaacggaa cttaagtcag
     5401 gaaggaaacc attcagcgta aacaagcaca acatgtagtc tgtcggctgt ctggaagcaa
     5461 aaataaatta ataaataaat aataaataag taaaagacac acacggaggt gaagatgaaa
     5521 tgtgatggat tccgagacaa tggggcacca aggcctgtag gcctcctctt gattttgctt
     5581 tggttatgtt tgttttcctt agagatgttt ttttcctcac gggacttgaa gtgactcatc
     5641 tctgtgcagt aatggtttcg ccatatgctc atttcaagta ttatagacat atgtaatggt
     5701 gaaatatatg aactgtggcc tttttcattc ttgttatttg tgatgcaatt aagtgaagag
     5761 aagaaaaaaa aaagcagaga tttaccatgt atcagtgcct ggctttttgt tataaagctt
     5821 cgtctgtcta gtgctctttt tgctataaaa atagactgta gtacacccta gtaggaaaaa
     5881 aaaaccctaa atttaaaaat aaaaaaatat atttggctta tttttcgcag gagcaatcct
     5941 tttataccat ggatattaca aaaaaaaaaa ttgtcagatt ctgaatattt cttctttgta
     6001 gatttttgga atcattataa gtaaaagttt gttactttat tttactattt aaaagatgtt
     6061 attttgccat gtgttactga gatgaaactg tatggtatag cttcttctgt tcgttttttg
     6121 tttccggttt tttgtttgtt cgtttttggt tttttttttt tttgtttgtt tgttttgttt
     6181 tgtttttttt tcttagttgt aggtcgcagt aaggactttt ccttttgttt ttgttttttc
     6241 gttatgtttt gttttgtttt tgcgactgta cacatagctg cagcattaaa aacttttaaa
     6301 aaaatctgtt aaaaaaaaaa gaaaaaaaag ggaaaacgtt taaaaaaaaa agataaacag
     6361 ttacaccttg ttttcaacgt gtggctgagt gcctcgattt tttcatgttt ttggtgtatt
     6421 tctgatttgt agaagtgtcc aaacaggttg tgtcctggac ttccttcaag aggcgaacaa
     6481 cccagcttgg tctaggccat gacctgttcc catctgtagt tactcgatga agtcatgtac
     6541 atgaccgttc tgtagcaata aatgtgccat ttttataaa
//
LOCUS       NM_001437081            5084 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 8, mRNA.
ACCESSION   NM_001437081 XM_063288037
VERSION     NM_001437081.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5084)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5084)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5084)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5084)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5084)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5084)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5084)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5084)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5084)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5084)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.789757.1,
                                           SRR26643290.20647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1467           JAXUCZ010000005.1  148197680-148197781
            1468-1619           JAXUCZ010000005.1  148200975-148201126
            1620-1758           JAXUCZ010000005.1  148203568-148203706
            1759-1902           JAXUCZ010000005.1  148205552-148205695
            1903-2199           JAXUCZ010000005.1  148206678-148206974
            2200-2467           JAXUCZ010000005.1  148218465-148218732
            2468-2597           JAXUCZ010000005.1  148219783-148219912
            2598-2732           JAXUCZ010000005.1  148221617-148221751
            2733-2870           JAXUCZ010000005.1  148225153-148225290
            2871-2996           JAXUCZ010000005.1  148228732-148228857
            2997-3118           JAXUCZ010000005.1  148229514-148229635
            3119-3311           JAXUCZ010000005.1  148231206-148231398
            3312-5084           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5084
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3443
                     /gene="Pum1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 8"
                     /protein_id="NP_001424010.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAAT
                     LGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGA
                     SQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALV
                     VNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLG
                     TQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLG
                     ATLGSALGGFGTAGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRY
                     GMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAE
                     RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGC
                     RVIQKALEFIPSDQQVINEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIID
                     AFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHV
                     LEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDG
                     PHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLE
                     KYYMKNGVDLGPICGPPNGII"
     misc_feature    2403..3374
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2403..3374
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2571..2576,2583..2585,2679..2684,2691..2693,
                     2796..2798,2805..2807,2901..2906,2913..2915,3000..3005,
                     3009..3014,3021..3023,3108..3113,3117..3122,3129..3131,
                     3237..3242,3246..3251,3258..3260,3348..3350,3357..3359)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2571..2576,2583..2585,2679..2684,2691..2693,
                     2796..2798,2805..2807,2901..2906,2913..2915,3000..3005,
                     3009..3014,3021..3023,3108..3113,3117..3122,3129..3131,
                     3237..3242,3246..3251,3258..3260,3348..3350,3357..3359)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1619
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1758
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1902
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2199
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2597
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2732
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2870
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3118
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3311
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..5084
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggttta gctcccgctg
     1381 cgtttgtccc caacccatac atcatcagcg ctgctccccc agggacggac ccctacacag
     1441 ctggattggc tgcagcagcg acactcggcc cagctgtggt ccctcaccaa tattatggag
     1501 tcacgccatg gggtgtctat cctgctagtc ttttccagca acaagctgct gcagctgcag
     1561 cagcaacaaa ttcagctact cagcagagtg ccccacaggc ccagcaggga cagcagcagg
     1621 ttcttcgtgg aggagctagc cagcgtcctt tgaccccaaa tcagaaccag cagggacaac
     1681 aaacagatcc ccttgtagca gctgcagcag tgaactctgc tcttgccttt ggacaaggat
     1741 tggctgcagg tatgccaggt tatccagtct tggcacctgc tgcttactat gaccaaactg
     1801 gtgcccttgt ggtgaatgca ggggcaagaa atggcctcgg agctccagtt cggcttgttg
     1861 ctccagcccc agtcatcatt agctcctcag ctgcacaagc agctgttgca gcggctgcag
     1921 cttcagcaaa tggagcagcc ggtggtcttg caggaactac aaatggacca tttcgacctt
     1981 taggcaccca gcagccccag ccccagcccc agcagcagcc cagtaacaat ctggcttcca
     2041 gctctttcta tggcaacaac tctctgagca gtaactccca gagcagctcc ctcttctctc
     2101 agggctccgc ccagcctgcc aacacgtcct tgggattcgg aagcagcagt tcccttggtg
     2161 ccaccctagg atcggccctt ggagggtttg gaacagcagg aggactcacg aacggcagtg
     2221 gaagatacat ctctgctgct cctggtgccg aagccaagta ccgcagtgcg agcagtgcct
     2281 ccagcctttt cagccccagc agcacccttt tttcttcctc tcgtttgaga tacggaatgt
     2341 ctgatgttat gccctctggc aggagcagac ttctggaaga ctttcgaaac aaccggtacc
     2401 ctaatttaca actgcgggag attgccgggc atataatgga attttcccaa gaccagcatg
     2461 gttctagatt cattcagctg aaactagagc gagccacagc agctgagcgc cagcttgtct
     2521 tcaacgaaat cctgcaggct gcgtaccaac ttatggtgga tgtgtttgga aattacgtca
     2581 ttcagaagtt ctttgaattt ggcagccatg aacagaagct ggctttggct gaacggattc
     2641 gaggccacgt cctatcattg gcactgcaga tgtatggctg ccgagtcatc cagaaagctt
     2701 tggaatttat tccctcagac cagcaggtaa ttaacgagat ggtgcgggag ctagatggcc
     2761 atgtcctgaa gtgtgtgaaa gaccagaatg gcaaccatgt ggttcagaag tgcattgaat
     2821 gtgtacagcc ccagtctttg cagttcatca tcgatgcatt caaggggcag gtgtttgctt
     2881 tgtctacgca cccatatggc tgtagggtga tccagaggat cctggaacac tgtctccccg
     2941 accagaccct ccctatcctg gaggagcttc accagcacac ggagcagctc gtgcaggatc
     3001 agtatggaaa ttatgtaatc caacatgtcc tggagcatgg tcgtcctgag gataaaagca
     3061 aaattgtagc agagatccga ggcaatgtac ttgtattgag tcagcacaaa ttcgcaagca
     3121 atgttgtgga gaagtgtgtc actcacgcct cacgtacaga gcgtgctgtg ctcattgatg
     3181 aggtatgcac catgaatgac ggtccccaca gtgccttata caccatgatg aaggatcagt
     3241 atgccaatta tgtggtccag aagatgatcg atgtggctga gccggggcag cggaagattg
     3301 tcatgcacaa gatccggcca cacatcgcga ctcttcggaa gtacacctat ggcaagcaca
     3361 tcctggccaa gcttgagaag tactacatga agaatggtgt ggacttgggg cccatttgtg
     3421 gtccccctaa tgggatcatc tgagcagtgc acccatccct gtcccgctga cctcactgac
     3481 cctggcagat ccaaccagca accagagatg cccagctcag agtcgaaagt gggcgatggt
     3541 tgctccggga ttgctccctc ctccaaaaat ggaatcggat ccacttgtgg aaaggccttt
     3601 gtaaatttca ttttattaca cataacatgt actaattatt ttttttaatt gactaattgc
     3661 cctgctgttt actggtgtat aggaacttgt acataggtaa tcagtgtaca tgagaggcca
     3721 catgctttgt tcaatgttgt atctatattc cacatgtgga cactttcagg gtggttggtt
     3781 taacaaaaaa agttttaaaa aaagacaaaa aaaggttttt aactcatttg ccttgtggca
     3841 agttttgcaa atagctcttc cccaccccat tttattaaaa aaagaaacct gagaaatttg
     3901 aattttagtt aaataatctc aaactggcat ttaacactgt ttataaaata tatatatata
     3961 tatacatata tacatatgaa atgggaacgt ttccgagttg ctaaagcatc agcctgtgat
     4021 acggagttta tgacgctctt tggagatgac ctcatgctga gggaggtggt agctgcagat
     4081 ccaggaggag cgggaagcac agagacaggc cggaggccag tgggcatggc cacttgctct
     4141 atgggttgcc ttctgtgaac actgggaagc agaatctgat tatctagcat gagagaaccc
     4201 agctctgctc ctggtctggc ttctatagat acatagtgta tacttgtgta gactttgcat
     4261 atatacggat ttgtagtatt ttcctgtttt gatgtctaat ctgtatctat aatgtaccct
     4321 agtagtcgga catacttttg attgtacaat tgtacatttg tatacctgta atgtaaatgt
     4381 ggagaagttt gaatcaacat gaacacgttt ttggtaagaa gagaaccggc cagcccgtgc
     4441 actctgtata tcccaccttt tatggttgta gcagatagtg ttgtatattg taaattgtaa
     4501 tttcaaacag aagtaaattt ttttcttttg aaggaataaa tgttctttat acagcctagt
     4561 taatgtttaa aaagaaaaaa tagcttggtt tatttgtcag ctagtcaaga cggtagtgag
     4621 agcctttcta aatgttactt cagatgattc agttcacact agtgttcctt tttttttttt
     4681 tatcctaaga aaaggtaatg tttcgcttat tttgtgacag tcaaaaggat gtgcagaagt
     4741 ttcgcctgcc ccttccctgc tcaccacctc cccttgtaaa gtgactcacc ctccgttttg
     4801 tacagatgag ctgtattttg cattttgtct acttgtaagt gaatgtaaca tactgtcaat
     4861 cctcgtttga atatagactg taacactaca cggtgtacat ttccagagcc ttgtgtatat
     4921 ttccaatgaa ctttttgcaa gcacacttgt aaccatatgt gtataattaa caaacctgtg
     4981 tatgcttatg cctgggcaac tattttttgt aactcttgtg tagattgtct ctaaacaatg
     5041 tgtgatcttt attttgaaaa aaatacagaa ctttggaatc tgaa
//
LOCUS       NM_001437092            5030 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 14, mRNA.
ACCESSION   NM_001437092 XM_063288052
VERSION     NM_001437092.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.16250.1,
                                           SRR26643297.20302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-712             JAXUCZ010000005.1  148181206-148181372
            713-983             JAXUCZ010000005.1  148183570-148183840
            984-1077            JAXUCZ010000005.1  148195258-148195351
            1078-1182           JAXUCZ010000005.1  148197677-148197781
            1183-1334           JAXUCZ010000005.1  148200975-148201126
            1335-1473           JAXUCZ010000005.1  148203568-148203706
            1474-1617           JAXUCZ010000005.1  148205552-148205695
            1618-1914           JAXUCZ010000005.1  148206678-148206974
            1915-2151           JAXUCZ010000005.1  148208059-148208295
            2152-2419           JAXUCZ010000005.1  148218465-148218732
            2420-2549           JAXUCZ010000005.1  148219783-148219912
            2550-2678           JAXUCZ010000005.1  148221617-148221745
            2679-2816           JAXUCZ010000005.1  148225153-148225290
            2817-2942           JAXUCZ010000005.1  148228732-148228857
            2943-3064           JAXUCZ010000005.1  148229514-148229635
            3065-3257           JAXUCZ010000005.1  148231206-148231398
            3258-5030           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5030
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3389
                     /gene="Pum1"
                     /note="isoform 14 is encoded by transcript variant 14;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 14"
                     /protein_id="NP_001424021.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEGPRDADSDENDKGEKK
                     NKGAFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGP
                     NQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSA
                     AATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPY
                     IISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNS
                     ATQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAA
                     GMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAA
                     SANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLF
                     SQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKR
                     TSSSLAPIGHSFYNSLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGL
                     TNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLED
                     FRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLM
                     VDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQN
                     EMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRV
                     IQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRG
                     NVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVV
                     QKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPN
                     GII"
     misc_feature    2355..3320
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2355..3320
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2523..2528,2535..2537,2631..2636,2643..2645,
                     2742..2744,2751..2753,2847..2852,2859..2861,2946..2951,
                     2955..2960,2967..2969,3054..3059,3063..3068,3075..3077,
                     3183..3188,3192..3197,3204..3206,3294..3296,3303..3305)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2523..2528,2535..2537,2631..2636,2643..2645,
                     2742..2744,2751..2753,2847..2852,2859..2861,2946..2951,
                     2955..2960,2967..2969,3054..3059,3063..3068,3075..3077,
                     3183..3188,3192..3197,3204..3206,3294..3296,3303..3305)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..712
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1182
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1334
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1473
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1617
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1914
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2151
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2419
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2549
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2678
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2816
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2942
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3064
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3257
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..5030
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagggccc aagggatgca gacagtgatg aaaacgacaa aggtgaaaag aagaacaagg
      601 gtgcgtttga tggagataag ctaggagatt tgaaggagga gggagatgtg atggacaaga
      661 ccaatggttt gccagtgcag aatgggattg atgcagacgt caaagatttt agccgtaccc
      721 ctggtaattg ccagagctct gctaatgaag tggatcttct gggtccaaac cagaatggtt
      781 ctgagggctt agcccagctg accagcacca atggtgccaa gcctgtggag gatttctcca
      841 acatggagtc ccagagtgtc cccttggacc ccatggaaca tgtgggcatg gagcctctgc
      901 agtttgatta ttcaggcacg caggtacctg tggactcagc agcagcaaca gtgggacttt
      961 ttgactacaa ttctcaacaa cagctattcc aaagacccaa tgcgcttgct gttcagcagt
     1021 tgacagctgc ccagcagcag caatatgcac ttgcagcagc ccaccagcct cacatcgcag
     1081 gtttagctcc cgctgcgttt gtccccaacc catacatcat cagcgctgct cccccaggga
     1141 cggaccccta cacagctgga ttggctgcag cagcgacact cggcccagct gtggtccctc
     1201 accaatatta tggagtcacg ccatggggtg tctatcctgc tagtcttttc cagcaacaag
     1261 ctgctgcagc tgcagcagca acaaattcag ctactcagca gagtgcccca caggcccagc
     1321 agggacagca gcaggttctt cgtggaggag ctagccagcg tcctttgacc ccaaatcaga
     1381 accagcaggg acaacaaaca gatccccttg tagcagctgc agcagtgaac tctgctcttg
     1441 cctttggaca aggattggct gcaggtatgc caggttatcc agtcttggca cctgctgctt
     1501 actatgacca aactggtgcc cttgtggtga atgcaggggc aagaaatggc ctcggagctc
     1561 cagttcggct tgttgctcca gccccagtca tcattagctc ctcagctgca caagcagctg
     1621 ttgcagcggc tgcagcttca gcaaatggag cagccggtgg tcttgcagga actacaaatg
     1681 gaccatttcg acctttaggc acccagcagc cccagcccca gccccagcag cagcccagta
     1741 acaatctggc ttccagctct ttctatggca acaactctct gagcagtaac tcccagagca
     1801 gctccctctt ctctcagggc tccgcccagc ctgccaacac gtccttggga ttcggaagca
     1861 gcagttccct tggtgccacc ctaggatcgg cccttggagg gtttggaaca gcagttgcaa
     1921 actccaacac tggcagtggc tcccgccgtg actccctgac tggcagcagt gacctttata
     1981 agaggacatc gagcagcttg gcccccattg gacacagttt ttataacagc cttagctttt
     2041 cctcctctcc tggacccgtg ggcatgcctc tccctagtca gggaccagga cattcacaga
     2101 caccacctcc ttccctctct tcacatggat cctcttcaag cttaaacctg ggaggactca
     2161 cgaacggcag tggaagatac atctctgctg ctcctggtgc cgaagccaag taccgcagtg
     2221 cgagcagtgc ctccagcctt ttcagcccca gcagcaccct tttttcttcc tctcgtttga
     2281 gatacggaat gtctgatgtt atgccctctg gcaggagcag acttctggaa gactttcgaa
     2341 acaaccggta ccctaattta caactgcggg agattgccgg gcatataatg gaattttccc
     2401 aagaccagca tggttctaga ttcattcagc tgaaactaga gcgagccaca gcagctgagc
     2461 gccagcttgt cttcaacgaa atcctgcagg ctgcgtacca acttatggtg gatgtgtttg
     2521 gaaattacgt cattcagaag ttctttgaat ttggcagcca tgaacagaag ctggctttgg
     2581 ctgaacggat tcgaggccac gtcctatcat tggcactgca gatgtatggc tgccgagtca
     2641 tccagaaagc tttggaattt attccctcag accagcagaa cgagatggtg cgggagctag
     2701 atggccatgt cctgaagtgt gtgaaagacc agaatggcaa ccatgtggtt cagaagtgca
     2761 ttgaatgtgt acagccccag tctttgcagt tcatcatcga tgcattcaag gggcaggtgt
     2821 ttgctttgtc tacgcaccca tatggctgta gggtgatcca gaggatcctg gaacactgtc
     2881 tccccgacca gaccctccct atcctggagg agcttcacca gcacacggag cagctcgtgc
     2941 aggatcagta tggaaattat gtaatccaac atgtcctgga gcatggtcgt cctgaggata
     3001 aaagcaaaat tgtagcagag atccgaggca atgtacttgt attgagtcag cacaaattcg
     3061 caagcaatgt tgtggagaag tgtgtcactc acgcctcacg tacagagcgt gctgtgctca
     3121 ttgatgaggt atgcaccatg aatgacggtc cccacagtgc cttatacacc atgatgaagg
     3181 atcagtatgc caattatgtg gtccagaaga tgatcgatgt ggctgagccg gggcagcgga
     3241 agattgtcat gcacaagatc cggccacaca tcgcgactct tcggaagtac acctatggca
     3301 agcacatcct ggccaagctt gagaagtact acatgaagaa tggtgtggac ttggggccca
     3361 tttgtggtcc ccctaatggg atcatctgag cagtgcaccc atccctgtcc cgctgacctc
     3421 actgaccctg gcagatccaa ccagcaacca gagatgccca gctcagagtc gaaagtgggc
     3481 gatggttgct ccgggattgc tccctcctcc aaaaatggaa tcggatccac ttgtggaaag
     3541 gcctttgtaa atttcatttt attacacata acatgtacta attatttttt ttaattgact
     3601 aattgccctg ctgtttactg gtgtatagga acttgtacat aggtaatcag tgtacatgag
     3661 aggccacatg ctttgttcaa tgttgtatct atattccaca tgtggacact ttcagggtgg
     3721 ttggtttaac aaaaaaagtt ttaaaaaaag acaaaaaaag gtttttaact catttgcctt
     3781 gtggcaagtt ttgcaaatag ctcttcccca ccccatttta ttaaaaaaag aaacctgaga
     3841 aatttgaatt ttagttaaat aatctcaaac tggcatttaa cactgtttat aaaatatata
     3901 tatatatata catatataca tatgaaatgg gaacgtttcc gagttgctaa agcatcagcc
     3961 tgtgatacgg agtttatgac gctctttgga gatgacctca tgctgaggga ggtggtagct
     4021 gcagatccag gaggagcggg aagcacagag acaggccgga ggccagtggg catggccact
     4081 tgctctatgg gttgccttct gtgaacactg ggaagcagaa tctgattatc tagcatgaga
     4141 gaacccagct ctgctcctgg tctggcttct atagatacat agtgtatact tgtgtagact
     4201 ttgcatatat acggatttgt agtattttcc tgttttgatg tctaatctgt atctataatg
     4261 taccctagta gtcggacata cttttgattg tacaattgta catttgtata cctgtaatgt
     4321 aaatgtggag aagtttgaat caacatgaac acgtttttgg taagaagaga accggccagc
     4381 ccgtgcactc tgtatatccc accttttatg gttgtagcag atagtgttgt atattgtaaa
     4441 ttgtaatttc aaacagaagt aaattttttt cttttgaagg aataaatgtt ctttatacag
     4501 cctagttaat gtttaaaaag aaaaaatagc ttggtttatt tgtcagctag tcaagacggt
     4561 agtgagagcc tttctaaatg ttacttcaga tgattcagtt cacactagtg ttcctttttt
     4621 tttttttatc ctaagaaaag gtaatgtttc gcttattttg tgacagtcaa aaggatgtgc
     4681 agaagtttcg cctgcccctt ccctgctcac cacctcccct tgtaaagtga ctcaccctcc
     4741 gttttgtaca gatgagctgt attttgcatt ttgtctactt gtaagtgaat gtaacatact
     4801 gtcaatcctc gtttgaatat agactgtaac actacacggt gtacatttcc agagccttgt
     4861 gtatatttcc aatgaacttt ttgcaagcac acttgtaacc atatgtgtat aattaacaaa
     4921 cctgtgtatg cttatgcctg ggcaactatt ttttgtaact cttgtgtaga ttgtctctaa
     4981 acaatgtgtg atctttattt tgaaaaaaat acagaacttt ggaatctgaa
//
LOCUS       NM_001437068            7452 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            6, mRNA.
ACCESSION   NM_001437068 XM_063277623
VERSION     NM_001437068.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7452)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7452)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7452)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7452)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7452)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7452)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7452)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7452)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7452)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7452)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277623.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1463682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-632             JAXUCZ010000018.1  65221421-65221493
            633-694             JAXUCZ010000018.1  65334541-65334602
            695-791             JAXUCZ010000018.1  65337982-65338078
            792-853             JAXUCZ010000018.1  65391770-65391831
            854-980             JAXUCZ010000018.1  65437942-65438068
            981-1030            JAXUCZ010000018.1  65438528-65438577
            1031-1136           JAXUCZ010000018.1  65507173-65507278
            1137-1267           JAXUCZ010000018.1  65511025-65511155
            1268-1400           JAXUCZ010000018.1  65516916-65517048
            1401-1468           JAXUCZ010000018.1  65525175-65525242
            1469-1547           JAXUCZ010000018.1  65526319-65526397
            1548-1624           JAXUCZ010000018.1  65528841-65528917
            1625-1828           JAXUCZ010000018.1  65531547-65531750
            1829-1964           JAXUCZ010000018.1  65551334-65551469
            1965-2127           JAXUCZ010000018.1  65553405-65553567
            2128-2357           JAXUCZ010000018.1  65556812-65557041
            2358-2498           JAXUCZ010000018.1  65557878-65558018
            2499-7452           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7452
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    536..538
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             560..2494
                     /gene="Tcf4"
                     /note="isoform 6 is encoded by transcript variant 6;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 6"
                     /protein_id="NP_001423997.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQSLLG
                     GDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVYA
                     PSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGN
                     SHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGT
                     DSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAV
                     WSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMH
                     GIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQL
                     PVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLD
                     DDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGR
                     MVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPP
                     LSLAGPHPGMGDAANHMGQM"
     misc_feature    728..>1372
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    728..>1372
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2162..2416
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2162..2416
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2186..2188,2198..2200,2204..2212,2216..2218,
                     2231..2233,2294..2299)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2186..2188,2198..2200,2204..2212,2216..2218,
                     2231..2233,2294..2299)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2225..2230,2237..2242,2246..2251,2258..2260,
                     2270..2272,2300..2302,2309..2311,2321..2323,2330..2332,
                     2339..2356)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2225..2230,2237..2242,2246..2251,2258..2260,
                     2270..2272,2300..2302,2309..2311,2321..2323,2330..2332,
                     2339..2356)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            560..632
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..694
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..791
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..853
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..980
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1030
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1136
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1267
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1400
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1468
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1547
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1624
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1828
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1964
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2127
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2357
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2498
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..7452
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaaga tgttttcgcc tcctgtaagc agtgggaaaa atggaccaac
      601 ttctttggcg agtggacatt ttacgggctc aaatgtagaa gacagaagta gctcagggtc
      661 ctgggggaat ggaggtcatc caagcccgtc caggaactat ggagatggga ctccctatga
      721 ccacatgact agcagggatc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc
      781 cagaatacaa agtaaaacag aaaggggttc atactcatct tatgggagag aaaacgtaca
      841 gggttgccac cagagtctcc tcggagggga catggatatg ggcaacccag gaaccctttc
      901 gcccaccaaa cctggctccc agtactaccc atattccagc aataacgccc gacggaggcc
      961 tcttcacagt agtaccatgg aggtgcagac aaagaaagtc agaaaagttc ctccaggctt
     1021 gccatcttca gtctacgctc cttcagccag cactgccgac tacaacaggg actcaccagg
     1081 ctattcttcc tccaagccag cagccagcac tttctccagc tccttcttca tgcaagatgg
     1141 ccatcacagc agtgaccctt ggagctcctc cagtggaatg aatcagcccg gctatggagg
     1201 gatgctaggc aactctcata tcccacagtc tagcagctac tgtagcctgc atccacatga
     1261 acgtctgagc tatccatcgc actcctcggc agacatcaac tccagtcttc ctccgatgtc
     1321 cacgttccat cgaagtggca caaaccatta cagcacctct tcctgcacac ctcctgccaa
     1381 cggaacagac agtataatgg caaacagagg aactggggca gcaggcagct cccagactgg
     1441 agacgctctg gggaaagccc tggcttcgat ctattctcct gatcacacga acaacagctt
     1501 ctcctccaac ccttcaactc ctgttggctc ccctccttca ctctcagcag gcacagctgt
     1561 ttggtctcga aacggaggac aggcctcgtc atctcccaat tacgaaggac ccttgcactc
     1621 cttgcagagc cgaattgaag accgtttaga aagactggac gacgcgattc atgttctccg
     1681 gaaccacgcg gtgggcccat ccacagctgt gcccggtggc catggggaca tgcatgggat
     1741 catcggaccc tctcacaatg gagcaatggg cagtctgggc tcaggatatg gaactggcct
     1801 tctctcagcc aacagacatt cactcatggt cggggcccac cgtgaagatg gcgtggcact
     1861 gagaggcagc cattctctcc tgccaaacca ggttccggtt ccacagcttc cagtccagtc
     1921 tgcaacttcc cctgacttga acccacccca agacccttac agagggatgc caccaggcct
     1981 ccagggacag agtgtgtctt ccggcagctc tgagatcaag tccgacgacg agggcgatga
     2041 gaacctacag gacacaaaat cttccgagga caagaaacta gacgacgaca agaaggatat
     2101 caaatcaatt actaggtcaa gatctagcaa taacgatgat gaggacctga ccccggagca
     2161 gaaggccgag cgtgagaagg agcggaggat ggccaataac gcccgtgagc gcctgagggt
     2221 ccgtgatatc aacgaggctt tcaaggagct gggccgcatg gtacagctcc acctgaagag
     2281 cgacaagccc cagaccaagc tcctgattct ccaccaggca gtggctgtca tcctcagcct
     2341 ggagcagcaa gtgcgagaaa ggaacctgaa cccaaaagct gcctgtctga aaagaaggga
     2401 ggaagagaag gtgtcctcag agcctccccc gctctccttg gctggcccac accctgggat
     2461 gggagacgca gcgaatcaca tgggtcagat gtgaaagggt ccaagttgcc accttgcttc
     2521 attaaaacaa gagaccactt ccttaacagc tgtattatcc taaacccaca taaacactgc
     2581 tccttaaccc cgtttttttt gtaatataag acaagtctga gtagttatga atcgcagacg
     2641 caagaggttt cagcattccc aattatcaaa aaacagaaaa acaaacacaa aaaaaaaatg
     2701 aatgaaagaa agaaagaaag agaaaatgca acttgaggga cgacttcttt aacatatcac
     2761 tctgaatgtg cgaagcggta tgtacaggct gagacgcagc ccagagactg aatggcaatc
     2821 cttccacact gtggagcaat gcatttgtgc ctaaacttct tttggaaaaa aaaatataat
     2881 taatttgtaa gtctgaaaaa aaatatttaa tttaaaaaaa attgtaaact tgcaataatg
     2941 aaaaagtgta cttctgaaga aaaacgacat gaacgttttt gttggtattc aagtcagcta
     3001 gtgtttctaa ttaccggata ttgaatagag gaagcccggc taccctcata acaaaaccag
     3061 caaccgtcct gatggcaacc gaaatgatga cattagccat tccttagggt aggagggaca
     3121 gatggatgtt atagacctat gacaaatata tatataaata tatatataaa tatatattaa
     3181 aaatttagtg actatggtaa gcttttgttc atttgtttca gacttttttc tcctgtaaaa
     3241 aaatagtact gattaacttt tttaaaagaa agattttact gtaaatatgg attttttttt
     3301 gtctgatttt tgtcccttcc cccagtttgt tatcgtgacc tgtagtgcca actctgcttc
     3361 cggaggggca gtgcaggacg aaatgctgac cctgatgttg cttctcattc ataaatagta
     3421 gaaagttgtt tctccagtct tttgggaaca caggacttaa aagtcacatc atgtgtagaa
     3481 attacatgca gcattgcccg ggcaaggcaa aaagagtttg tctggcttgt ggcactgtgc
     3541 ttgttaccct ctcctgggat tttcagaggt acacggttag aatgctacaa tgttaccact
     3601 gtgccttcca atgtttatat catcggaaac atgacataat caaagtggct gtgatttaac
     3661 aaaaaaaaaa aaagattcaa gtgttaccta cctgtgtagc ggaagtagtg tgcagtgaga
     3721 cgtttctgaa tacatggtca gatttttttt ggaaaaaata caaaaacaaa aaaaaaaaac
     3781 aaaaaaattt aaaaaaaaaa gtcaagttca aaaaccgtca aatgagaaaa tcgcaaggag
     3841 tgtgacagct gattgatttt gttgcttttc ttgatttttt tttttttgtt tccaaatggg
     3901 tttactaaaa agtacatgac ttacctgcct cctccttcgt ctgaaaacaa aaaacaaaaa
     3961 aacaatgcca acctatccca cagcattata gcaagcctta taagccctaa agcattaagt
     4021 tgcactttgg tgaggagggg tagcgcagta ttctctctgg ccagtatgag tgaagtttat
     4081 acttaacatt tgatagaaac atagatcaaa ctgtggcaca gtaactcatc agatagctag
     4141 cgttgactct gggcacaatt gaaccaattc ccatcctaaa tctttccaac aattgacttt
     4201 ggtgtacagt gcagtgaaca catagaactc ctacttaagt attcgtcagc atccttttgt
     4261 ctctaactcg gttctgtttt gacagccaca caatcttggc atgtattaag taaaaaaaaa
     4321 aaaaaaatcc ctgttgaagt agttttccca cctatcagca ctgagtaatt gccgtaactc
     4381 aatggaaatg gtctaaacgc cccccatctc ttgtcctgta ccaccagtta cacagtgaca
     4441 aaacacatct gtaaatttta tgcaaccaat ggcaaaccta tcattatttt gaaactgtgt
     4501 atgtaaaagt tatattttta catgtagact cttgttatta tgtgttttaa tacattgtat
     4561 cagttttttg tttccttttt tttttaactg tgtggtttta aaaagtcatt taaatgaaat
     4621 agcgagctac aagaatctga aatttatgtt catttctgaa aatgtaagaa caaataagat
     4681 agttatcacg tggtcacctt ttacaaaccc atcgatgttt tgactagctg tgtgtatgtg
     4741 tgtgtgtgcg catgtgtgcg tgtgtgtgta tgtgtgttga aaactgtaaa tatgttcagt
     4801 agcgataaaa cgacaatgct ttgatttgtt gagaagttcc taaaatgtgg aggtggattg
     4861 aaaatgtagg ggaatagcag aaatcagatt tcatgaagag ctcttctctt cgggggcttt
     4921 cctgtggaat ggtcaaacag aggtgctcca agaagggcaa ggaagacagt aacttcccct
     4981 cctccctgaa cgacggaaac catgtgtacg tggtctctca ccatgttaaa gattttcttt
     5041 ccgtgataca ttctgcactc tttttgtata gtctaccaag gcgggtatcc ctgggaacaa
     5101 tattatgata taggaagcag tatactctga tcacattcag gagaattgta tagaagagaa
     5161 tatggtgttt actctttagg gaactggaaa ttctccctgc attgatgtac atcttcagag
     5221 cggccctttt gatacacgtt atcataaagg tgctgactaa agcagaatta aagtttttca
     5281 aatctgtaaa caaagcaaaa aattaaatta cagtcattcg attgtttgtt tttttttttt
     5341 tccaattggt gcttttatat tttgttctca ctcagacaga aaaggctgca atttcttgtt
     5401 caccagcttt gatgtattca ttactcggta atgtaatacg gctattgtca aattcctttt
     5461 ggaaataagc aaaaggcttc cccaaggcct gcagcagctg ctggctactt tctgcttggc
     5521 gcagaaacat gatctgaccc tctctgtagt aatcgagttg tatctccagt tttaaaaaga
     5581 aggaaaaagg gaatgtggcc gttttaatgt gttttttttt ttcttttctt gttgttattt
     5641 tgtaattctc aaacccaggt aagatattgg tattcctgca ctggattttt gaaagaaact
     5701 tagcagaaga caggatcgag atactataga agcatttccc aagtgttcat actatactag
     5761 acataaatga taacggcgat gtataggttc aggatcggtt taagagactc agactttgaa
     5821 agcaacttgg aacggttgat ccacctccac attcgagtaa ttaataattc tgcagaatta
     5881 gggatctgtc catctaggag ttgttaccca tttgtcttct gtgtggctgc gaggaacact
     5941 aacgctttta caactgtcag ttcacccagt ggtacaactg attctgactc agtcttccga
     6001 ttcctgtttt gtattttgtt tttccacttt tttcctatct cttgatttta ttgttgttgt
     6061 tattgctatt gttattatta ttattcgtga tctttatttc gatgaggggt tgggaagtgg
     6121 gagggagtcg aactgagact aggggttgag aggatttttt tggtttggtt ttcttttctt
     6181 ttttttttgt tttttttttt ttttgtttgt ttgtttcatc tttgcgtcca acaggcagaa
     6241 tatggtctgt gtccaaaacg gaacttaagt caggaaggaa accattcagc gtaaacaagc
     6301 acaacatgta gtctgtcggc tgtctggaag caaaaataaa ttaataaata aataataaat
     6361 aagtaaaaga cacacacgga ggtgaagatg aaatgtgatg gattccgaga caatggggca
     6421 ccaaggcctg taggcctcct cttgattttg ctttggttat gtttgttttc cttagagatg
     6481 tttttttcct cacgggactt gaagtgactc atctctgtgc agtaatggtt tcgccatatg
     6541 ctcatttcaa gtattataga catatgtaat ggtgaaatat atgaactgtg gcctttttca
     6601 ttcttgttat ttgtgatgca attaagtgaa gagaagaaaa aaaaaagcag agatttacca
     6661 tgtatcagtg cctggctttt tgttataaag cttcgtctgt ctagtgctct ttttgctata
     6721 aaaatagact gtagtacacc ctagtaggaa aaaaaaaccc taaatttaaa aataaaaaaa
     6781 tatatttggc ttatttttcg caggagcaat ccttttatac catggatatt acaaaaaaaa
     6841 aaattgtcag attctgaata tttcttcttt gtagattttt ggaatcatta taagtaaaag
     6901 tttgttactt tattttacta tttaaaagat gttattttgc catgtgttac tgagatgaaa
     6961 ctgtatggta tagcttcttc tgttcgtttt ttgtttccgg ttttttgttt gttcgttttt
     7021 ggtttttttt ttttttgttt gtttgttttg ttttgttttt ttttcttagt tgtaggtcgc
     7081 agtaaggact tttccttttg tttttgtttt ttcgttatgt tttgttttgt ttttgcgact
     7141 gtacacatag ctgcagcatt aaaaactttt aaaaaaatct gttaaaaaaa aaagaaaaaa
     7201 aagggaaaac gtttaaaaaa aaaagataaa cagttacacc ttgttttcaa cgtgtggctg
     7261 agtgcctcga ttttttcatg tttttggtgt atttctgatt tgtagaagtg tccaaacagg
     7321 ttgtgtcctg gacttccttc aagaggcgaa caacccagct tggtctaggc catgacctgt
     7381 tcccatctgt agttactcga tgaagtcatg tacatgaccg ttctgtagca ataaatgtgc
     7441 catttttata aa
//
LOCUS       NM_001437089            6582 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            16, mRNA.
ACCESSION   NM_001437089 XM_039097189
VERSION     NM_001437089.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6582)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6582)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6582)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6582)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6582)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6582)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6582)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6582)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6582)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6582)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097189.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54619.1,
                                           SRR26643299.63249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-766             JAXUCZ010000018.1  65528841-65528917
            767-970             JAXUCZ010000018.1  65531547-65531750
            971-1106            JAXUCZ010000018.1  65551334-65551469
            1107-1257           JAXUCZ010000018.1  65553405-65553555
            1258-1487           JAXUCZ010000018.1  65556812-65557041
            1488-1628           JAXUCZ010000018.1  65557878-65558018
            1629-6582           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6582
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1624
                     /gene="Tcf4"
                     /note="isoform 16 is encoded by transcript variant 16;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 16"
                     /protein_id="NP_001424018.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPL
                     HSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGY
                     GTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYR
                     GMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDL
                     TPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAV
                     AVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    1292..1546
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1292..1546
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1316..1318,1328..1330,1334..1342,1346..1348,
                     1361..1363,1424..1429)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1316..1318,1328..1330,1334..1342,1346..1348,
                     1361..1363,1424..1429)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1355..1360,1367..1372,1376..1381,1388..1390,
                     1400..1402,1430..1432,1439..1441,1451..1453,1460..1462,
                     1469..1486)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1355..1360,1367..1372,1376..1381,1388..1390,
                     1400..1402,1430..1432,1439..1441,1451..1453,1460..1462,
                     1469..1486)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..766
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..970
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1106
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1257
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1628
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..6582
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagc aggcacagct gtttggtctc gaaacggagg
      721 acaggcctcg tcatctccca attacgaagg acccttgcac tccttgcaga gccgaattga
      781 agaccgttta gaaagactgg acgacgcgat tcatgttctc cggaaccacg cggtgggccc
      841 atccacagct gtgcccggtg gccatgggga catgcatggg atcatcggac cctctcacaa
      901 tggagcaatg ggcagtctgg gctcaggata tggaactggc cttctctcag ccaacagaca
      961 ttcactcatg gtcggggccc accgtgaaga tggcgtggca ctgagaggca gccattctct
     1021 cctgccaaac caggttccgg ttccacagct tccagtccag tctgcaactt cccctgactt
     1081 gaacccaccc caagaccctt acagagggat gccaccaggc ctccagggac agagtgtgtc
     1141 ttccggcagc tctgagatca agtccgacga cgagggcgat gagaacctac aggacacaaa
     1201 atcttccgag gacaagaaac tagacgacga caagaaggat atcaaatcaa ttactagcaa
     1261 taacgatgat gaggacctga ccccggagca gaaggccgag cgtgagaagg agcggaggat
     1321 ggccaataac gcccgtgagc gcctgagggt ccgtgatatc aacgaggctt tcaaggagct
     1381 gggccgcatg gtacagctcc acctgaagag cgacaagccc cagaccaagc tcctgattct
     1441 ccaccaggca gtggctgtca tcctcagcct ggagcagcaa gtgcgagaaa ggaacctgaa
     1501 cccaaaagct gcctgtctga aaagaaggga ggaagagaag gtgtcctcag agcctccccc
     1561 gctctccttg gctggcccac accctgggat gggagacgca gcgaatcaca tgggtcagat
     1621 gtgaaagggt ccaagttgcc accttgcttc attaaaacaa gagaccactt ccttaacagc
     1681 tgtattatcc taaacccaca taaacactgc tccttaaccc cgtttttttt gtaatataag
     1741 acaagtctga gtagttatga atcgcagacg caagaggttt cagcattccc aattatcaaa
     1801 aaacagaaaa acaaacacaa aaaaaaaatg aatgaaagaa agaaagaaag agaaaatgca
     1861 acttgaggga cgacttcttt aacatatcac tctgaatgtg cgaagcggta tgtacaggct
     1921 gagacgcagc ccagagactg aatggcaatc cttccacact gtggagcaat gcatttgtgc
     1981 ctaaacttct tttggaaaaa aaaatataat taatttgtaa gtctgaaaaa aaatatttaa
     2041 tttaaaaaaa attgtaaact tgcaataatg aaaaagtgta cttctgaaga aaaacgacat
     2101 gaacgttttt gttggtattc aagtcagcta gtgtttctaa ttaccggata ttgaatagag
     2161 gaagcccggc taccctcata acaaaaccag caaccgtcct gatggcaacc gaaatgatga
     2221 cattagccat tccttagggt aggagggaca gatggatgtt atagacctat gacaaatata
     2281 tatataaata tatatataaa tatatattaa aaatttagtg actatggtaa gcttttgttc
     2341 atttgtttca gacttttttc tcctgtaaaa aaatagtact gattaacttt tttaaaagaa
     2401 agattttact gtaaatatgg attttttttt gtctgatttt tgtcccttcc cccagtttgt
     2461 tatcgtgacc tgtagtgcca actctgcttc cggaggggca gtgcaggacg aaatgctgac
     2521 cctgatgttg cttctcattc ataaatagta gaaagttgtt tctccagtct tttgggaaca
     2581 caggacttaa aagtcacatc atgtgtagaa attacatgca gcattgcccg ggcaaggcaa
     2641 aaagagtttg tctggcttgt ggcactgtgc ttgttaccct ctcctgggat tttcagaggt
     2701 acacggttag aatgctacaa tgttaccact gtgccttcca atgtttatat catcggaaac
     2761 atgacataat caaagtggct gtgatttaac aaaaaaaaaa aaagattcaa gtgttaccta
     2821 cctgtgtagc ggaagtagtg tgcagtgaga cgtttctgaa tacatggtca gatttttttt
     2881 ggaaaaaata caaaaacaaa aaaaaaaaac aaaaaaattt aaaaaaaaaa gtcaagttca
     2941 aaaaccgtca aatgagaaaa tcgcaaggag tgtgacagct gattgatttt gttgcttttc
     3001 ttgatttttt tttttttgtt tccaaatggg tttactaaaa agtacatgac ttacctgcct
     3061 cctccttcgt ctgaaaacaa aaaacaaaaa aacaatgcca acctatccca cagcattata
     3121 gcaagcctta taagccctaa agcattaagt tgcactttgg tgaggagggg tagcgcagta
     3181 ttctctctgg ccagtatgag tgaagtttat acttaacatt tgatagaaac atagatcaaa
     3241 ctgtggcaca gtaactcatc agatagctag cgttgactct gggcacaatt gaaccaattc
     3301 ccatcctaaa tctttccaac aattgacttt ggtgtacagt gcagtgaaca catagaactc
     3361 ctacttaagt attcgtcagc atccttttgt ctctaactcg gttctgtttt gacagccaca
     3421 caatcttggc atgtattaag taaaaaaaaa aaaaaaatcc ctgttgaagt agttttccca
     3481 cctatcagca ctgagtaatt gccgtaactc aatggaaatg gtctaaacgc cccccatctc
     3541 ttgtcctgta ccaccagtta cacagtgaca aaacacatct gtaaatttta tgcaaccaat
     3601 ggcaaaccta tcattatttt gaaactgtgt atgtaaaagt tatattttta catgtagact
     3661 cttgttatta tgtgttttaa tacattgtat cagttttttg tttccttttt tttttaactg
     3721 tgtggtttta aaaagtcatt taaatgaaat agcgagctac aagaatctga aatttatgtt
     3781 catttctgaa aatgtaagaa caaataagat agttatcacg tggtcacctt ttacaaaccc
     3841 atcgatgttt tgactagctg tgtgtatgtg tgtgtgtgcg catgtgtgcg tgtgtgtgta
     3901 tgtgtgttga aaactgtaaa tatgttcagt agcgataaaa cgacaatgct ttgatttgtt
     3961 gagaagttcc taaaatgtgg aggtggattg aaaatgtagg ggaatagcag aaatcagatt
     4021 tcatgaagag ctcttctctt cgggggcttt cctgtggaat ggtcaaacag aggtgctcca
     4081 agaagggcaa ggaagacagt aacttcccct cctccctgaa cgacggaaac catgtgtacg
     4141 tggtctctca ccatgttaaa gattttcttt ccgtgataca ttctgcactc tttttgtata
     4201 gtctaccaag gcgggtatcc ctgggaacaa tattatgata taggaagcag tatactctga
     4261 tcacattcag gagaattgta tagaagagaa tatggtgttt actctttagg gaactggaaa
     4321 ttctccctgc attgatgtac atcttcagag cggccctttt gatacacgtt atcataaagg
     4381 tgctgactaa agcagaatta aagtttttca aatctgtaaa caaagcaaaa aattaaatta
     4441 cagtcattcg attgtttgtt tttttttttt tccaattggt gcttttatat tttgttctca
     4501 ctcagacaga aaaggctgca atttcttgtt caccagcttt gatgtattca ttactcggta
     4561 atgtaatacg gctattgtca aattcctttt ggaaataagc aaaaggcttc cccaaggcct
     4621 gcagcagctg ctggctactt tctgcttggc gcagaaacat gatctgaccc tctctgtagt
     4681 aatcgagttg tatctccagt tttaaaaaga aggaaaaagg gaatgtggcc gttttaatgt
     4741 gttttttttt ttcttttctt gttgttattt tgtaattctc aaacccaggt aagatattgg
     4801 tattcctgca ctggattttt gaaagaaact tagcagaaga caggatcgag atactataga
     4861 agcatttccc aagtgttcat actatactag acataaatga taacggcgat gtataggttc
     4921 aggatcggtt taagagactc agactttgaa agcaacttgg aacggttgat ccacctccac
     4981 attcgagtaa ttaataattc tgcagaatta gggatctgtc catctaggag ttgttaccca
     5041 tttgtcttct gtgtggctgc gaggaacact aacgctttta caactgtcag ttcacccagt
     5101 ggtacaactg attctgactc agtcttccga ttcctgtttt gtattttgtt tttccacttt
     5161 tttcctatct cttgatttta ttgttgttgt tattgctatt gttattatta ttattcgtga
     5221 tctttatttc gatgaggggt tgggaagtgg gagggagtcg aactgagact aggggttgag
     5281 aggatttttt tggtttggtt ttcttttctt ttttttttgt tttttttttt ttttgtttgt
     5341 ttgtttcatc tttgcgtcca acaggcagaa tatggtctgt gtccaaaacg gaacttaagt
     5401 caggaaggaa accattcagc gtaaacaagc acaacatgta gtctgtcggc tgtctggaag
     5461 caaaaataaa ttaataaata aataataaat aagtaaaaga cacacacgga ggtgaagatg
     5521 aaatgtgatg gattccgaga caatggggca ccaaggcctg taggcctcct cttgattttg
     5581 ctttggttat gtttgttttc cttagagatg tttttttcct cacgggactt gaagtgactc
     5641 atctctgtgc agtaatggtt tcgccatatg ctcatttcaa gtattataga catatgtaat
     5701 ggtgaaatat atgaactgtg gcctttttca ttcttgttat ttgtgatgca attaagtgaa
     5761 gagaagaaaa aaaaaagcag agatttacca tgtatcagtg cctggctttt tgttataaag
     5821 cttcgtctgt ctagtgctct ttttgctata aaaatagact gtagtacacc ctagtaggaa
     5881 aaaaaaaccc taaatttaaa aataaaaaaa tatatttggc ttatttttcg caggagcaat
     5941 ccttttatac catggatatt acaaaaaaaa aaattgtcag attctgaata tttcttcttt
     6001 gtagattttt ggaatcatta taagtaaaag tttgttactt tattttacta tttaaaagat
     6061 gttattttgc catgtgttac tgagatgaaa ctgtatggta tagcttcttc tgttcgtttt
     6121 ttgtttccgg ttttttgttt gttcgttttt ggtttttttt ttttttgttt gtttgttttg
     6181 ttttgttttt ttttcttagt tgtaggtcgc agtaaggact tttccttttg tttttgtttt
     6241 ttcgttatgt tttgttttgt ttttgcgact gtacacatag ctgcagcatt aaaaactttt
     6301 aaaaaaatct gttaaaaaaa aaagaaaaaa aagggaaaac gtttaaaaaa aaaagataaa
     6361 cagttacacc ttgttttcaa cgtgtggctg agtgcctcga ttttttcatg tttttggtgt
     6421 atttctgatt tgtagaagtg tccaaacagg ttgtgtcctg gacttccttc aagaggcgaa
     6481 caacccagct tggtctaggc catgacctgt tcccatctgt agttactcga tgaagtcatg
     6541 tacatgaccg ttctgtagca ataaatgtgc catttttata aa
//
LOCUS       NM_001437095            6576 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            19, mRNA.
ACCESSION   NM_001437095 XM_063277631
VERSION     NM_001437095.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6576)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6576)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6576)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6576)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6576)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6576)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6576)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6576)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6576)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6576)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277631.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2240825.1,
                                           SRR26360176.2350447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000018.1  65468033-65468204
            173-278             JAXUCZ010000018.1  65507173-65507278
            279-409             JAXUCZ010000018.1  65511025-65511155
            410-542             JAXUCZ010000018.1  65516916-65517048
            543-610             JAXUCZ010000018.1  65525175-65525242
            611-689             JAXUCZ010000018.1  65526319-65526397
            690-763             JAXUCZ010000018.1  65528844-65528917
            764-964             JAXUCZ010000018.1  65531550-65531750
            965-1100            JAXUCZ010000018.1  65551334-65551469
            1101-1251           JAXUCZ010000018.1  65553405-65553555
            1252-1481           JAXUCZ010000018.1  65556812-65557041
            1482-1622           JAXUCZ010000018.1  65557878-65558018
            1623-6576           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6576
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             104..1618
                     /gene="Tcf4"
                     /note="isoform 19 is encoded by transcript variant 19;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 19"
                     /protein_id="NP_001424024.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYSSS
                     KPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERL
                     SYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTG
                     DALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSGTAVWSRNGGQASSSPNYEGPLH
                     SLSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGT
                     GLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGM
                     PPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTP
                     EQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAV
                     ILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    1286..1540
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1286..1540
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1310..1312,1322..1324,1328..1336,1340..1342,
                     1355..1357,1418..1423)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1310..1312,1322..1324,1328..1336,1340..1342,
                     1355..1357,1418..1423)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1349..1354,1361..1366,1370..1375,1382..1384,
                     1394..1396,1424..1426,1433..1435,1445..1447,1454..1456,
                     1463..1480)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1349..1354,1361..1366,1370..1375,1382..1384,
                     1394..1396,1424..1426,1433..1435,1445..1447,1454..1456,
                     1463..1480)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            173..278
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            279..409
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..542
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..610
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..689
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..763
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..964
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1100
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1251
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1481
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1622
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..6576
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtctacgc
      181 tccttcagcc agcactgccg actacaacag ggactcacca ggctattctt cctccaagcc
      241 agcagccagc actttctcca gctccttctt catgcaagat ggccatcaca gcagtgaccc
      301 ttggagctcc tccagtggaa tgaatcagcc cggctatgga gggatgctag gcaactctca
      361 tatcccacag tctagcagct actgtagcct gcatccacat gaacgtctga gctatccatc
      421 gcactcctcg gcagacatca actccagtct tcctccgatg tccacgttcc atcgaagtgg
      481 cacaaaccat tacagcacct cttcctgcac acctcctgcc aacggaacag acagtataat
      541 ggcaaacaga ggaactgggg cagcaggcag ctcccagact ggagacgctc tggggaaagc
      601 cctggcttcg atctattctc ctgatcacac gaacaacagc ttctcctcca acccttcaac
      661 tcctgttggc tcccctcctt cactctcagg cacagctgtt tggtctcgaa acggaggaca
      721 ggcctcgtca tctcccaatt acgaaggacc cttgcactcc ttgagccgaa ttgaagaccg
      781 tttagaaaga ctggacgacg cgattcatgt tctccggaac cacgcggtgg gcccatccac
      841 agctgtgccc ggtggccatg gggacatgca tgggatcatc ggaccctctc acaatggagc
      901 aatgggcagt ctgggctcag gatatggaac tggccttctc tcagccaaca gacattcact
      961 catggtcggg gcccaccgtg aagatggcgt ggcactgaga ggcagccatt ctctcctgcc
     1021 aaaccaggtt ccggttccac agcttccagt ccagtctgca acttcccctg acttgaaccc
     1081 accccaagac ccttacagag ggatgccacc aggcctccag ggacagagtg tgtcttccgg
     1141 cagctctgag atcaagtccg acgacgaggg cgatgagaac ctacaggaca caaaatcttc
     1201 cgaggacaag aaactagacg acgacaagaa ggatatcaaa tcaattacta gcaataacga
     1261 tgatgaggac ctgaccccgg agcagaaggc cgagcgtgag aaggagcgga ggatggccaa
     1321 taacgcccgt gagcgcctga gggtccgtga tatcaacgag gctttcaagg agctgggccg
     1381 catggtacag ctccacctga agagcgacaa gccccagacc aagctcctga ttctccacca
     1441 ggcagtggct gtcatcctca gcctggagca gcaagtgcga gaaaggaacc tgaacccaaa
     1501 agctgcctgt ctgaaaagaa gggaggaaga gaaggtgtcc tcagagcctc ccccgctctc
     1561 cttggctggc ccacaccctg ggatgggaga cgcagcgaat cacatgggtc agatgtgaaa
     1621 gggtccaagt tgccaccttg cttcattaaa acaagagacc acttccttaa cagctgtatt
     1681 atcctaaacc cacataaaca ctgctcctta accccgtttt ttttgtaata taagacaagt
     1741 ctgagtagtt atgaatcgca gacgcaagag gtttcagcat tcccaattat caaaaaacag
     1801 aaaaacaaac acaaaaaaaa aatgaatgaa agaaagaaag aaagagaaaa tgcaacttga
     1861 gggacgactt ctttaacata tcactctgaa tgtgcgaagc ggtatgtaca ggctgagacg
     1921 cagcccagag actgaatggc aatccttcca cactgtggag caatgcattt gtgcctaaac
     1981 ttcttttgga aaaaaaaata taattaattt gtaagtctga aaaaaaatat ttaatttaaa
     2041 aaaaattgta aacttgcaat aatgaaaaag tgtacttctg aagaaaaacg acatgaacgt
     2101 ttttgttggt attcaagtca gctagtgttt ctaattaccg gatattgaat agaggaagcc
     2161 cggctaccct cataacaaaa ccagcaaccg tcctgatggc aaccgaaatg atgacattag
     2221 ccattcctta gggtaggagg gacagatgga tgttatagac ctatgacaaa tatatatata
     2281 aatatatata taaatatata ttaaaaattt agtgactatg gtaagctttt gttcatttgt
     2341 ttcagacttt tttctcctgt aaaaaaatag tactgattaa cttttttaaa agaaagattt
     2401 tactgtaaat atggattttt ttttgtctga tttttgtccc ttcccccagt ttgttatcgt
     2461 gacctgtagt gccaactctg cttccggagg ggcagtgcag gacgaaatgc tgaccctgat
     2521 gttgcttctc attcataaat agtagaaagt tgtttctcca gtcttttggg aacacaggac
     2581 ttaaaagtca catcatgtgt agaaattaca tgcagcattg cccgggcaag gcaaaaagag
     2641 tttgtctggc ttgtggcact gtgcttgtta ccctctcctg ggattttcag aggtacacgg
     2701 ttagaatgct acaatgttac cactgtgcct tccaatgttt atatcatcgg aaacatgaca
     2761 taatcaaagt ggctgtgatt taacaaaaaa aaaaaaagat tcaagtgtta cctacctgtg
     2821 tagcggaagt agtgtgcagt gagacgtttc tgaatacatg gtcagatttt ttttggaaaa
     2881 aatacaaaaa caaaaaaaaa aaacaaaaaa atttaaaaaa aaaagtcaag ttcaaaaacc
     2941 gtcaaatgag aaaatcgcaa ggagtgtgac agctgattga ttttgttgct tttcttgatt
     3001 tttttttttt tgtttccaaa tgggtttact aaaaagtaca tgacttacct gcctcctcct
     3061 tcgtctgaaa acaaaaaaca aaaaaacaat gccaacctat cccacagcat tatagcaagc
     3121 cttataagcc ctaaagcatt aagttgcact ttggtgagga ggggtagcgc agtattctct
     3181 ctggccagta tgagtgaagt ttatacttaa catttgatag aaacatagat caaactgtgg
     3241 cacagtaact catcagatag ctagcgttga ctctgggcac aattgaacca attcccatcc
     3301 taaatctttc caacaattga ctttggtgta cagtgcagtg aacacataga actcctactt
     3361 aagtattcgt cagcatcctt ttgtctctaa ctcggttctg ttttgacagc cacacaatct
     3421 tggcatgtat taagtaaaaa aaaaaaaaaa atccctgttg aagtagtttt cccacctatc
     3481 agcactgagt aattgccgta actcaatgga aatggtctaa acgcccccca tctcttgtcc
     3541 tgtaccacca gttacacagt gacaaaacac atctgtaaat tttatgcaac caatggcaaa
     3601 cctatcatta ttttgaaact gtgtatgtaa aagttatatt tttacatgta gactcttgtt
     3661 attatgtgtt ttaatacatt gtatcagttt tttgtttcct ttttttttta actgtgtggt
     3721 tttaaaaagt catttaaatg aaatagcgag ctacaagaat ctgaaattta tgttcatttc
     3781 tgaaaatgta agaacaaata agatagttat cacgtggtca ccttttacaa acccatcgat
     3841 gttttgacta gctgtgtgta tgtgtgtgtg tgcgcatgtg tgcgtgtgtg tgtatgtgtg
     3901 ttgaaaactg taaatatgtt cagtagcgat aaaacgacaa tgctttgatt tgttgagaag
     3961 ttcctaaaat gtggaggtgg attgaaaatg taggggaata gcagaaatca gatttcatga
     4021 agagctcttc tcttcggggg ctttcctgtg gaatggtcaa acagaggtgc tccaagaagg
     4081 gcaaggaaga cagtaacttc ccctcctccc tgaacgacgg aaaccatgtg tacgtggtct
     4141 ctcaccatgt taaagatttt ctttccgtga tacattctgc actctttttg tatagtctac
     4201 caaggcgggt atccctggga acaatattat gatataggaa gcagtatact ctgatcacat
     4261 tcaggagaat tgtatagaag agaatatggt gtttactctt tagggaactg gaaattctcc
     4321 ctgcattgat gtacatcttc agagcggccc ttttgataca cgttatcata aaggtgctga
     4381 ctaaagcaga attaaagttt ttcaaatctg taaacaaagc aaaaaattaa attacagtca
     4441 ttcgattgtt tgtttttttt tttttccaat tggtgctttt atattttgtt ctcactcaga
     4501 cagaaaaggc tgcaatttct tgttcaccag ctttgatgta ttcattactc ggtaatgtaa
     4561 tacggctatt gtcaaattcc ttttggaaat aagcaaaagg cttccccaag gcctgcagca
     4621 gctgctggct actttctgct tggcgcagaa acatgatctg accctctctg tagtaatcga
     4681 gttgtatctc cagttttaaa aagaaggaaa aagggaatgt ggccgtttta atgtgttttt
     4741 ttttttcttt tcttgttgtt attttgtaat tctcaaaccc aggtaagata ttggtattcc
     4801 tgcactggat ttttgaaaga aacttagcag aagacaggat cgagatacta tagaagcatt
     4861 tcccaagtgt tcatactata ctagacataa atgataacgg cgatgtatag gttcaggatc
     4921 ggtttaagag actcagactt tgaaagcaac ttggaacggt tgatccacct ccacattcga
     4981 gtaattaata attctgcaga attagggatc tgtccatcta ggagttgtta cccatttgtc
     5041 ttctgtgtgg ctgcgaggaa cactaacgct tttacaactg tcagttcacc cagtggtaca
     5101 actgattctg actcagtctt ccgattcctg ttttgtattt tgtttttcca cttttttcct
     5161 atctcttgat tttattgttg ttgttattgc tattgttatt attattattc gtgatcttta
     5221 tttcgatgag gggttgggaa gtgggaggga gtcgaactga gactaggggt tgagaggatt
     5281 tttttggttt ggttttcttt tctttttttt ttgttttttt ttttttttgt ttgtttgttt
     5341 catctttgcg tccaacaggc agaatatggt ctgtgtccaa aacggaactt aagtcaggaa
     5401 ggaaaccatt cagcgtaaac aagcacaaca tgtagtctgt cggctgtctg gaagcaaaaa
     5461 taaattaata aataaataat aaataagtaa aagacacaca cggaggtgaa gatgaaatgt
     5521 gatggattcc gagacaatgg ggcaccaagg cctgtaggcc tcctcttgat tttgctttgg
     5581 ttatgtttgt tttccttaga gatgtttttt tcctcacggg acttgaagtg actcatctct
     5641 gtgcagtaat ggtttcgcca tatgctcatt tcaagtatta tagacatatg taatggtgaa
     5701 atatatgaac tgtggccttt ttcattcttg ttatttgtga tgcaattaag tgaagagaag
     5761 aaaaaaaaaa gcagagattt accatgtatc agtgcctggc tttttgttat aaagcttcgt
     5821 ctgtctagtg ctctttttgc tataaaaata gactgtagta caccctagta ggaaaaaaaa
     5881 accctaaatt taaaaataaa aaaatatatt tggcttattt ttcgcaggag caatcctttt
     5941 ataccatgga tattacaaaa aaaaaaattg tcagattctg aatatttctt ctttgtagat
     6001 ttttggaatc attataagta aaagtttgtt actttatttt actatttaaa agatgttatt
     6061 ttgccatgtg ttactgagat gaaactgtat ggtatagctt cttctgttcg ttttttgttt
     6121 ccggtttttt gtttgttcgt ttttggtttt tttttttttt gtttgtttgt tttgttttgt
     6181 ttttttttct tagttgtagg tcgcagtaag gacttttcct tttgtttttg ttttttcgtt
     6241 atgttttgtt ttgtttttgc gactgtacac atagctgcag cattaaaaac ttttaaaaaa
     6301 atctgttaaa aaaaaaagaa aaaaaaggga aaacgtttaa aaaaaaaaga taaacagtta
     6361 caccttgttt tcaacgtgtg gctgagtgcc tcgatttttt catgtttttg gtgtatttct
     6421 gatttgtaga agtgtccaaa caggttgtgt cctggacttc cttcaagagg cgaacaaccc
     6481 agcttggtct aggccatgac ctgttcccat ctgtagttac tcgatgaagt catgtacatg
     6541 accgttctgt agcaataaat gtgccatttt tataaa
//
LOCUS       NM_001437029            2309 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 16, mRNA.
ACCESSION   NM_001437029
VERSION     NM_001437029.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1649567.1,
                                           SRR21887622.2182944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-425             JAXUCZ010000016.1  6893598-6893876
            426-684             JAXUCZ010000016.1  6894275-6894533
            685-834             JAXUCZ010000016.1  6898222-6898371
            835-2309            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2309
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..425
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    340..342
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            426..684
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..2007
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 16; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 2 precursor"
                     /protein_id="NP_001423958.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     sig_peptide     442..516
                     /gene="Btd"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1)"
     mat_peptide     517..2004
                     /gene="Btd"
                     /product="Biotinidase. /evidence=ECO:0000255.
                     /id=PRO_0000292882"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVF9.1)"
     misc_feature    547..1458
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    547..1458
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(709..711,1009..1011,1021..1023,1027..1029,
                     1108..1113,1117..1122,1186..1188)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(709..711,1009..1011,1021..1023,1027..1029,
                     1108..1113,1117..1122,1186..1188)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(709..711,1009..1011,1108..1110)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(709..711,1009..1011,1108..1110)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    823..825
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    982..984
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     misc_feature    order(1012..1026,1045..1053,1111..1113,1117..1131,
                     1138..1143,1204..1209,1213..1221,1225..1230,1300..1305,
                     1444..1458)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(1012..1026,1045..1053,1111..1113,1117..1131,
                     1138..1143,1204..1209,1213..1221,1225..1230,1300..1305,
                     1444..1458)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1552..2001
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1552..2001
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1579..1581
                     /gene="Btd"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5FVF9.1); glycosylation site"
     exon            685..834
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            835..2309
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaaaa tcccatgtta ccactatgag aaggattttc
      181 tttccaaagc ggtacgtcct taagcaagtg attcggagta gcagacaaag cagaaaacag
      241 tgaaagccgt gtgcgggact ctgacaggga gacttcttta tggctgccct gtgggtgaca
      301 cagcagatgc tagaattcca aaccgcccca aataaaaact gaagaatatc ggctaggaag
      361 ctgccctgcg ttcgggagcc tcaggaccat cgcggctgtc ctagagggct gacctgcaat
      421 gctatattta cggtctgcat tatgtctgga gcccgcactg cgcatgcgct cgtcttcctc
      481 ctcggctgtt ctgcgcttgc gttgggcgtc tgctcagcct ccctggagca cggcgaggct
      541 gagtactacg tggctgccgt gtacgaacac cgatcggtcc tgagcccaaa ccccctggag
      601 ctcagcagcc gccagcaggc cctggagctc atgaagcaga acctcgacgt ctatgaacag
      661 caagtgatgg ctgcagccca gaagggtgcg cacattatag tgttcccaga agacggtatc
      721 cacggattca acttcacaag aacatccatt tacccattct tggacttgat gccatctccc
      781 aggctggtca gttggaaccc gtgtctggag ccctttcgct tcaatgacac ggaggtcctc
      841 cagcgcctga gttgcatggc catcaaggga aagatgttct tggtggccaa tcttgggaca
      901 aaacagcctt gcctcggcag cgaccctggg tgcccgcagg acgggagata ccagtttaac
      961 acaaacgtcg cgttcagtga caacggaacc ctcgtcggcc gctaccgtaa gcacaacctg
     1021 tactttgagg aagccttcga tagccctgct gacgtggacc tcaccacctt tgatacgccg
     1081 ttcgcgggca agttcggtat gttcacttgc tttgatatcc tgttctttga ccccgcggtc
     1141 cggctcctca gagactttga ggtaaagcac attgcgtacc ctacggcctg gatgaaccag
     1201 ctgccgctct tggcagccat tgaaatccag aaagcattcg ccaccgcctt cggcgtcacc
     1261 gttctggcag ctaacatcca ccacccgact ctggggatga cgggcagtgg catacacacc
     1321 cctctgaagt ccttttggta ccataacatg gacgaccccg aaggtcacct tataattgcc
     1381 cgggtagcca caaacccaca gggcctcgtt gggacagaga atacaactag tgaaatggat
     1441 ccgtcccata ggaagttctt aaaagtcttg tctggggatc cgtactgtga gaaggatgcc
     1501 caggaagtgc gctgcgacga ggctgccaag tggaacctga acgcaccacc taccttccac
     1561 tcggagatga tgtatgacaa tttcaccctg gtccccgtct ggggaaagga aggccacctc
     1621 caggtgtgct ccaacagtct ctgttgccac ttacttttcg agaggcccgc cctgtccaaa
     1681 gagctatatg ccctgggtgt ctttgacgga ctccacacag tgcacggtac ctactacgtt
     1741 caagcctgtg ccctggtcaa gtgcgggggc gctggctttg aaacctgcgg gcaggagatc
     1801 tcggaggccg agggcttgtt tgactttcat ctgtggggga acttcagcac cttgtatgtc
     1861 ttccctttat ttctcacctc ggggatgacc ctagacaccc ctgaccagct cgggtgggag
     1921 agcgaccact atttcttgag gaagagggga ctgtcctccg gcctggtgac ggcagctctc
     1981 tatgggcggt tgtatgagag gaattaggaa aactgtggtc agcaggttgg gctctgcagg
     2041 ctggccttgc cttcccacgg cccacagatc ccaaacactg ggaaaaccgc cccgcccctg
     2101 tggcactgga tcccaccctg gggaactgta agaagatggg agaggcagtt cctccttcct
     2161 ttctacataa tgactgagat attttctggt attttctatt cacattattc tttttcaagc
     2221 cacaccctct taccactact acacaattgg ttttaaagac taagccaaaa aaaaaaaaaa
     2281 aaaataaaca tcagctgcca ttctacaaa
//
LOCUS       NM_001437017            2075 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 3, mRNA.
ACCESSION   NM_001437017 XM_039094453
VERSION     NM_001437017.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039094453.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32220.1,
                                           SRR26643295.51996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-191             JAXUCZ010000016.1  6893598-6893642
            192-450             JAXUCZ010000016.1  6894275-6894533
            451-600             JAXUCZ010000016.1  6898222-6898371
            601-2075            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2075
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..191
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1773
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_001423946.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MRRIFFPKRFTVCIMSGARTAHALVFLLGCSALALGVCSASLEH
                     GEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVF
                     PEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMF
                     LVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPAD
                     VDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEI
                     QKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQ
                     GLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY
                     DNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQAC
                     ALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWES
                     DHYFLRKRGLSSGLVTAALYGRLYERN"
     sig_peptide     166..276
                     /gene="Btd"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    313..1224
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    313..1224
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(475..477,775..777,787..789,793..795,874..879,
                     883..888,952..954)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(475..477,775..777,787..789,793..795,874..879,
                     883..888,952..954)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(475..477,775..777,874..876)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(475..477,775..777,874..876)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(778..792,811..819,877..879,883..897,904..909,
                     970..975,979..987,991..996,1066..1071,1210..1224)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(778..792,811..819,877..879,883..897,904..909,
                     970..975,979..987,991..996,1066..1071,1210..1224)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1318..1767
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1318..1767
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            192..450
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            451..600
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            601..2075
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaaaa tcccatgtta ccactatgag aaggattttc
      181 tttccaaagc gatttacggt ctgcattatg tctggagccc gcactgcgca tgcgctcgtc
      241 ttcctcctcg gctgttctgc gcttgcgttg ggcgtctgct cagcctccct ggagcacggc
      301 gaggctgagt actacgtggc tgccgtgtac gaacaccgat cggtcctgag cccaaacccc
      361 ctggagctca gcagccgcca gcaggccctg gagctcatga agcagaacct cgacgtctat
      421 gaacagcaag tgatggctgc agcccagaag ggtgcgcaca ttatagtgtt cccagaagac
      481 ggtatccacg gattcaactt cacaagaaca tccatttacc cattcttgga cttgatgcca
      541 tctcccaggc tggtcagttg gaacccgtgt ctggagccct ttcgcttcaa tgacacggag
      601 gtcctccagc gcctgagttg catggccatc aagggaaaga tgttcttggt ggccaatctt
      661 gggacaaaac agccttgcct cggcagcgac cctgggtgcc cgcaggacgg gagataccag
      721 tttaacacaa acgtcgcgtt cagtgacaac ggaaccctcg tcggccgcta ccgtaagcac
      781 aacctgtact ttgaggaagc cttcgatagc cctgctgacg tggacctcac cacctttgat
      841 acgccgttcg cgggcaagtt cggtatgttc acttgctttg atatcctgtt ctttgacccc
      901 gcggtccggc tcctcagaga ctttgaggta aagcacattg cgtaccctac ggcctggatg
      961 aaccagctgc cgctcttggc agccattgaa atccagaaag cattcgccac cgccttcggc
     1021 gtcaccgttc tggcagctaa catccaccac ccgactctgg ggatgacggg cagtggcata
     1081 cacacccctc tgaagtcctt ttggtaccat aacatggacg accccgaagg tcaccttata
     1141 attgcccggg tagccacaaa cccacagggc ctcgttggga cagagaatac aactagtgaa
     1201 atggatccgt cccataggaa gttcttaaaa gtcttgtctg gggatccgta ctgtgagaag
     1261 gatgcccagg aagtgcgctg cgacgaggct gccaagtgga acctgaacgc accacctacc
     1321 ttccactcgg agatgatgta tgacaatttc accctggtcc ccgtctgggg aaaggaaggc
     1381 cacctccagg tgtgctccaa cagtctctgt tgccacttac ttttcgagag gcccgccctg
     1441 tccaaagagc tatatgccct gggtgtcttt gacggactcc acacagtgca cggtacctac
     1501 tacgttcaag cctgtgccct ggtcaagtgc gggggcgctg gctttgaaac ctgcgggcag
     1561 gagatctcgg aggccgaggg cttgtttgac tttcatctgt gggggaactt cagcaccttg
     1621 tatgtcttcc ctttatttct cacctcgggg atgaccctag acacccctga ccagctcggg
     1681 tgggagagcg accactattt cttgaggaag aggggactgt cctccggcct ggtgacggca
     1741 gctctctatg ggcggttgta tgagaggaat taggaaaact gtggtcagca ggttgggctc
     1801 tgcaggctgg ccttgccttc ccacggccca cagatcccaa acactgggaa aaccgccccg
     1861 cccctgtggc actggatccc accctgggga actgtaagaa gatgggagag gcagttcctc
     1921 cttcctttct acataatgac tgagatattt tctggtattt tctattcaca ttattctttt
     1981 tcaagccaca ccctcttacc actactacac aattggtttt aaagactaag ccaaaaaaaa
     2041 aaaaaaaaaa taaacatcag ctgccattct acaaa
//
LOCUS       NM_001437051             589 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S5
            (Ndufs5), transcript variant 3, mRNA.
ACCESSION   NM_001437051 XM_006238828
VERSION     NM_001437051.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 589)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 589)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 589)
  AUTHORS   Huang,G., Chen,Y., Lu,H. and Cao,X.
  TITLE     Coupling mitochondrial respiratory chain to cell death: an
            essential role of mitochondrial complex I in the interferon-beta
            and retinoic acid-induced cancer cell death
  JOURNAL   Cell Death Differ 14 (2), 327-337 (2007)
   PUBMED   16826196
REFERENCE   4  (bases 1 to 589)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 589)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 589)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006238828.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.2028829.1,
                                           SRR22399484.995025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000005.1  141264262-141264418 c
            158-375             JAXUCZ010000005.1  141261991-141262208 c
            376-589             JAXUCZ010000005.1  141258828-141259041 c
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..589
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="NADH:ubiquinone oxidoreductase subunit S5"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
     exon            1..157
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..117
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="upstream in-frame stop codon"
     exon            158..375
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..480
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 5b,
                     15kDa (NADH-coenzyme Q reductase)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 5"
                     /protein_id="NP_001423980.1"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
                     /translation="MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECA
                     HGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLMKEGKYTPPPHHLGKE
                     EPRP"
     misc_feature    160..447
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     misc_feature    160..447
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     exon            376..589
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtctgc gtcctcctta agccggcggt cgtgagctgc gcccagggac ctgagaaggg
       61 cattgctgag gtgcggtagg cgcttgctgt gtccggtcag ccaagaaggt tcgctaggga
      121 ttgctcctag acaaatttcc tctcgtgggt gacccagtca tgcctttcct tgatgtgcag
      181 aaaaggctgg gcattagcct agatcgacac tttatattcc taagtgctga gcagccttac
      241 aagaatgccg ctcgatgcca cgcatttgaa aaggagtgga tagaatgcgc acatgggatc
      301 ggtgctaccc gggctaaaaa agagtgcaag atagagtatg aagactttga agaatgcttt
      361 cttcggttca aaacgataag gcggatgcat gaaatcaaga aacagcggga gaagctgatg
      421 aaagagggga agtacacccc tccgcctcac catttgggca aggaggagcc caggccctga
      481 gcagagcagc tagaagctgc tctccatgct ctgttttccg ctggagagaa tgtttaaggg
      541 aagcaccttc atcaagtatg tacaaataaa gaattactca acctagaaa
//
LOCUS       NM_001437064            7148 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            2, mRNA.
ACCESSION   NM_001437064 XM_063277616
VERSION     NM_001437064.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7148)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7148)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7148)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7148)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7148)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7148)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7148)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7148)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7148)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7148)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360176.2345999.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000018.1  65218587-65218749
            164-255             JAXUCZ010000018.1  65219645-65219736
            256-328             JAXUCZ010000018.1  65221421-65221493
            329-390             JAXUCZ010000018.1  65334541-65334602
            391-487             JAXUCZ010000018.1  65337982-65338078
            488-549             JAXUCZ010000018.1  65391770-65391831
            550-679             JAXUCZ010000018.1  65437939-65438068
            680-729             JAXUCZ010000018.1  65438528-65438577
            730-835             JAXUCZ010000018.1  65507173-65507278
            836-966             JAXUCZ010000018.1  65511025-65511155
            967-1099            JAXUCZ010000018.1  65516916-65517048
            1100-1167           JAXUCZ010000018.1  65525175-65525242
            1168-1246           JAXUCZ010000018.1  65526319-65526397
            1247-1320           JAXUCZ010000018.1  65528844-65528917
            1321-1524           JAXUCZ010000018.1  65531547-65531750
            1525-1660           JAXUCZ010000018.1  65551334-65551469
            1661-1823           JAXUCZ010000018.1  65553405-65553567
            1824-2053           JAXUCZ010000018.1  65556812-65557041
            2054-2194           JAXUCZ010000018.1  65557878-65558018
            2195-7148           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7148
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..163
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            164..255
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2190
                     /gene="Tcf4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 2"
                     /protein_id="NP_001423993.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDD
                     AIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGA
                     HREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSS
                     EIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKER
                     RMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRE
                     RNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    586..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    586..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1858..2112
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1858..2112
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1882..1884,1894..1896,1900..1908,1912..1914,
                     1927..1929,1990..1995)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1882..1884,1894..1896,1900..1908,1912..1914,
                     1927..1929,1990..1995)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1921..1926,1933..1938,1942..1947,1954..1956,
                     1966..1968,1996..1998,2005..2007,2017..2019,2026..2028,
                     2035..2052)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1921..1926,1933..1938,1942..1947,1954..1956,
                     1966..1968,1996..1998,2005..2007,2017..2019,2026..2028,
                     2035..2052)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            256..328
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..390
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..679
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..729
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..835
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1099
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1167
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1320
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1524
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1660
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1823
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2053
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2194
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..7148
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcgg atcggcggcg gcggcggcgg cggcggcggg gaagccggag cgggcgcggg
       61 cgccggccgt tggaggaggt ggtggtggcg gaggcagggg gatagacatg accgccgcct
      121 gggcgccggc gctgcaccgg gagcccctcg tcgcgcgcgg gcggtttgtg tgattttgct
      181 aaaatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct gagtgattta
      241 ctggatttca gtgcgatgtt ttcgcctcct gtaagcagtg ggaaaaatgg accaacttct
      301 ttggcgagtg gacattttac gggctcaaat gtagaagaca gaagtagctc agggtcctgg
      361 gggaatggag gtcatccaag cccgtccagg aactatggag atgggactcc ctatgaccac
      421 atgactagca gggatcttgg gtcacatgac aatctctctc caccttttgt caattccaga
      481 atacaaagta aaacagaaag gggttcatac tcatcttatg ggagagaaaa cgtacagggt
      541 tgccaccagc agagtctcct cggaggggac atggatatgg gcaacccagg aaccctttcg
      601 cccaccaaac ctggctccca gtactaccca tattccagca ataacgcccg acggaggcct
      661 cttcacagta gtaccatgga ggtgcagaca aagaaagtca gaaaagttcc tccaggcttg
      721 ccatcttcag tctacgctcc ttcagccagc actgccgact acaacaggga ctcaccaggc
      781 tattcttcct ccaagccagc agccagcact ttctccagct ccttcttcat gcaagatggc
      841 catcacagca gtgacccttg gagctcctcc agtggaatga atcagcccgg ctatggaggg
      901 atgctaggca actctcatat cccacagtct agcagctact gtagcctgca tccacatgaa
      961 cgtctgagct atccatcgca ctcctcggca gacatcaact ccagtcttcc tccgatgtcc
     1021 acgttccatc gaagtggcac aaaccattac agcacctctt cctgcacacc tcctgccaac
     1081 ggaacagaca gtataatggc aaacagagga actggggcag caggcagctc ccagactgga
     1141 gacgctctgg ggaaagccct ggcttcgatc tattctcctg atcacacgaa caacagcttc
     1201 tcctccaacc cttcaactcc tgttggctcc cctccttcac tctcaggcac agctgtttgg
     1261 tctcgaaacg gaggacaggc ctcgtcatct cccaattacg aaggaccctt gcactccttg
     1321 cagagccgaa ttgaagaccg tttagaaaga ctggacgacg cgattcatgt tctccggaac
     1381 cacgcggtgg gcccatccac agctgtgccc ggtggccatg gggacatgca tgggatcatc
     1441 ggaccctctc acaatggagc aatgggcagt ctgggctcag gatatggaac tggccttctc
     1501 tcagccaaca gacattcact catggtcggg gcccaccgtg aagatggcgt ggcactgaga
     1561 ggcagccatt ctctcctgcc aaaccaggtt ccggttccac agcttccagt ccagtctgca
     1621 acttcccctg acttgaaccc accccaagac ccttacagag ggatgccacc aggcctccag
     1681 ggacagagtg tgtcttccgg cagctctgag atcaagtccg acgacgaggg cgatgagaac
     1741 ctacaggaca caaaatcttc cgaggacaag aaactagacg acgacaagaa ggatatcaaa
     1801 tcaattacta ggtcaagatc tagcaataac gatgatgagg acctgacccc ggagcagaag
     1861 gccgagcgtg agaaggagcg gaggatggcc aataacgccc gtgagcgcct gagggtccgt
     1921 gatatcaacg aggctttcaa ggagctgggc cgcatggtac agctccacct gaagagcgac
     1981 aagccccaga ccaagctcct gattctccac caggcagtgg ctgtcatcct cagcctggag
     2041 cagcaagtgc gagaaaggaa cctgaaccca aaagctgcct gtctgaaaag aagggaggaa
     2101 gagaaggtgt cctcagagcc tcccccgctc tccttggctg gcccacaccc tgggatggga
     2161 gacgcagcga atcacatggg tcagatgtga aagggtccaa gttgccacct tgcttcatta
     2221 aaacaagaga ccacttcctt aacagctgta ttatcctaaa cccacataaa cactgctcct
     2281 taaccccgtt ttttttgtaa tataagacaa gtctgagtag ttatgaatcg cagacgcaag
     2341 aggtttcagc attcccaatt atcaaaaaac agaaaaacaa acacaaaaaa aaaatgaatg
     2401 aaagaaagaa agaaagagaa aatgcaactt gagggacgac ttctttaaca tatcactctg
     2461 aatgtgcgaa gcggtatgta caggctgaga cgcagcccag agactgaatg gcaatccttc
     2521 cacactgtgg agcaatgcat ttgtgcctaa acttcttttg gaaaaaaaaa tataattaat
     2581 ttgtaagtct gaaaaaaaat atttaattta aaaaaaattg taaacttgca ataatgaaaa
     2641 agtgtacttc tgaagaaaaa cgacatgaac gtttttgttg gtattcaagt cagctagtgt
     2701 ttctaattac cggatattga atagaggaag cccggctacc ctcataacaa aaccagcaac
     2761 cgtcctgatg gcaaccgaaa tgatgacatt agccattcct tagggtagga gggacagatg
     2821 gatgttatag acctatgaca aatatatata taaatatata tataaatata tattaaaaat
     2881 ttagtgacta tggtaagctt ttgttcattt gtttcagact tttttctcct gtaaaaaaat
     2941 agtactgatt aactttttta aaagaaagat tttactgtaa atatggattt ttttttgtct
     3001 gatttttgtc ccttccccca gtttgttatc gtgacctgta gtgccaactc tgcttccgga
     3061 ggggcagtgc aggacgaaat gctgaccctg atgttgcttc tcattcataa atagtagaaa
     3121 gttgtttctc cagtcttttg ggaacacagg acttaaaagt cacatcatgt gtagaaatta
     3181 catgcagcat tgcccgggca aggcaaaaag agtttgtctg gcttgtggca ctgtgcttgt
     3241 taccctctcc tgggattttc agaggtacac ggttagaatg ctacaatgtt accactgtgc
     3301 cttccaatgt ttatatcatc ggaaacatga cataatcaaa gtggctgtga tttaacaaaa
     3361 aaaaaaaaag attcaagtgt tacctacctg tgtagcggaa gtagtgtgca gtgagacgtt
     3421 tctgaataca tggtcagatt ttttttggaa aaaatacaaa aacaaaaaaa aaaaacaaaa
     3481 aaatttaaaa aaaaaagtca agttcaaaaa ccgtcaaatg agaaaatcgc aaggagtgtg
     3541 acagctgatt gattttgttg cttttcttga tttttttttt tttgtttcca aatgggttta
     3601 ctaaaaagta catgacttac ctgcctcctc cttcgtctga aaacaaaaaa caaaaaaaca
     3661 atgccaacct atcccacagc attatagcaa gccttataag ccctaaagca ttaagttgca
     3721 ctttggtgag gaggggtagc gcagtattct ctctggccag tatgagtgaa gtttatactt
     3781 aacatttgat agaaacatag atcaaactgt ggcacagtaa ctcatcagat agctagcgtt
     3841 gactctgggc acaattgaac caattcccat cctaaatctt tccaacaatt gactttggtg
     3901 tacagtgcag tgaacacata gaactcctac ttaagtattc gtcagcatcc ttttgtctct
     3961 aactcggttc tgttttgaca gccacacaat cttggcatgt attaagtaaa aaaaaaaaaa
     4021 aaatccctgt tgaagtagtt ttcccaccta tcagcactga gtaattgccg taactcaatg
     4081 gaaatggtct aaacgccccc catctcttgt cctgtaccac cagttacaca gtgacaaaac
     4141 acatctgtaa attttatgca accaatggca aacctatcat tattttgaaa ctgtgtatgt
     4201 aaaagttata tttttacatg tagactcttg ttattatgtg ttttaataca ttgtatcagt
     4261 tttttgtttc cttttttttt taactgtgtg gttttaaaaa gtcatttaaa tgaaatagcg
     4321 agctacaaga atctgaaatt tatgttcatt tctgaaaatg taagaacaaa taagatagtt
     4381 atcacgtggt caccttttac aaacccatcg atgttttgac tagctgtgtg tatgtgtgtg
     4441 tgtgcgcatg tgtgcgtgtg tgtgtatgtg tgttgaaaac tgtaaatatg ttcagtagcg
     4501 ataaaacgac aatgctttga tttgttgaga agttcctaaa atgtggaggt ggattgaaaa
     4561 tgtaggggaa tagcagaaat cagatttcat gaagagctct tctcttcggg ggctttcctg
     4621 tggaatggtc aaacagaggt gctccaagaa gggcaaggaa gacagtaact tcccctcctc
     4681 cctgaacgac ggaaaccatg tgtacgtggt ctctcaccat gttaaagatt ttctttccgt
     4741 gatacattct gcactctttt tgtatagtct accaaggcgg gtatccctgg gaacaatatt
     4801 atgatatagg aagcagtata ctctgatcac attcaggaga attgtataga agagaatatg
     4861 gtgtttactc tttagggaac tggaaattct ccctgcattg atgtacatct tcagagcggc
     4921 ccttttgata cacgttatca taaaggtgct gactaaagca gaattaaagt ttttcaaatc
     4981 tgtaaacaaa gcaaaaaatt aaattacagt cattcgattg tttgtttttt tttttttcca
     5041 attggtgctt ttatattttg ttctcactca gacagaaaag gctgcaattt cttgttcacc
     5101 agctttgatg tattcattac tcggtaatgt aatacggcta ttgtcaaatt ccttttggaa
     5161 ataagcaaaa ggcttcccca aggcctgcag cagctgctgg ctactttctg cttggcgcag
     5221 aaacatgatc tgaccctctc tgtagtaatc gagttgtatc tccagtttta aaaagaagga
     5281 aaaagggaat gtggccgttt taatgtgttt ttttttttct tttcttgttg ttattttgta
     5341 attctcaaac ccaggtaaga tattggtatt cctgcactgg atttttgaaa gaaacttagc
     5401 agaagacagg atcgagatac tatagaagca tttcccaagt gttcatacta tactagacat
     5461 aaatgataac ggcgatgtat aggttcagga tcggtttaag agactcagac tttgaaagca
     5521 acttggaacg gttgatccac ctccacattc gagtaattaa taattctgca gaattaggga
     5581 tctgtccatc taggagttgt tacccatttg tcttctgtgt ggctgcgagg aacactaacg
     5641 cttttacaac tgtcagttca cccagtggta caactgattc tgactcagtc ttccgattcc
     5701 tgttttgtat tttgtttttc cacttttttc ctatctcttg attttattgt tgttgttatt
     5761 gctattgtta ttattattat tcgtgatctt tatttcgatg aggggttggg aagtgggagg
     5821 gagtcgaact gagactaggg gttgagagga tttttttggt ttggttttct tttctttttt
     5881 ttttgttttt tttttttttt gtttgtttgt ttcatctttg cgtccaacag gcagaatatg
     5941 gtctgtgtcc aaaacggaac ttaagtcagg aaggaaacca ttcagcgtaa acaagcacaa
     6001 catgtagtct gtcggctgtc tggaagcaaa aataaattaa taaataaata ataaataagt
     6061 aaaagacaca cacggaggtg aagatgaaat gtgatggatt ccgagacaat ggggcaccaa
     6121 ggcctgtagg cctcctcttg attttgcttt ggttatgttt gttttcctta gagatgtttt
     6181 tttcctcacg ggacttgaag tgactcatct ctgtgcagta atggtttcgc catatgctca
     6241 tttcaagtat tatagacata tgtaatggtg aaatatatga actgtggcct ttttcattct
     6301 tgttatttgt gatgcaatta agtgaagaga agaaaaaaaa aagcagagat ttaccatgta
     6361 tcagtgcctg gctttttgtt ataaagcttc gtctgtctag tgctcttttt gctataaaaa
     6421 tagactgtag tacaccctag taggaaaaaa aaaccctaaa tttaaaaata aaaaaatata
     6481 tttggcttat ttttcgcagg agcaatcctt ttataccatg gatattacaa aaaaaaaaat
     6541 tgtcagattc tgaatatttc ttctttgtag atttttggaa tcattataag taaaagtttg
     6601 ttactttatt ttactattta aaagatgtta ttttgccatg tgttactgag atgaaactgt
     6661 atggtatagc ttcttctgtt cgttttttgt ttccggtttt ttgtttgttc gtttttggtt
     6721 tttttttttt ttgtttgttt gttttgtttt gttttttttt cttagttgta ggtcgcagta
     6781 aggacttttc cttttgtttt tgttttttcg ttatgttttg ttttgttttt gcgactgtac
     6841 acatagctgc agcattaaaa acttttaaaa aaatctgtta aaaaaaaaag aaaaaaaagg
     6901 gaaaacgttt aaaaaaaaaa gataaacagt tacaccttgt tttcaacgtg tggctgagtg
     6961 cctcgatttt ttcatgtttt tggtgtattt ctgatttgta gaagtgtcca aacaggttgt
     7021 gtcctggact tccttcaaga ggcgaacaac ccagcttggt ctaggccatg acctgttccc
     7081 atctgtagtt actcgatgaa gtcatgtaca tgaccgttct gtagcaataa atgtgccatt
     7141 tttataaa
//
LOCUS       NM_001437069            7443 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            7, mRNA.
ACCESSION   NM_001437069 XM_063277625
VERSION     NM_001437069.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7443)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7443)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7443)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7443)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7443)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7443)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7443)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7443)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7443)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7443)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063277625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.63240.1,
                                           SRR26360186.1499892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               JAXUCZ010000018.1  65216839-65217397
            560-632             JAXUCZ010000018.1  65221421-65221493
            633-694             JAXUCZ010000018.1  65334541-65334602
            695-791             JAXUCZ010000018.1  65337982-65338078
            792-853             JAXUCZ010000018.1  65391770-65391831
            854-983             JAXUCZ010000018.1  65437939-65438068
            984-1033            JAXUCZ010000018.1  65438528-65438577
            1034-1139           JAXUCZ010000018.1  65507173-65507278
            1140-1270           JAXUCZ010000018.1  65511025-65511155
            1271-1403           JAXUCZ010000018.1  65516916-65517048
            1404-1471           JAXUCZ010000018.1  65525175-65525242
            1472-1550           JAXUCZ010000018.1  65526319-65526397
            1551-1627           JAXUCZ010000018.1  65528841-65528917
            1628-1831           JAXUCZ010000018.1  65531547-65531750
            1832-1967           JAXUCZ010000018.1  65551334-65551469
            1968-2118           JAXUCZ010000018.1  65553405-65553555
            2119-2348           JAXUCZ010000018.1  65556812-65557041
            2349-2489           JAXUCZ010000018.1  65557878-65558018
            2490-7443           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7443
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..559
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    536..538
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     CDS             560..2485
                     /gene="Tcf4"
                     /note="isoform 7 is encoded by transcript variant 7;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 7"
                     /protein_id="NP_001423998.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPS
                     RNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLL
                     GGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVY
                     APSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLG
                     NSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANG
                     TDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA
                     VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDM
                     HGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQ
                     LPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKL
                     DDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQ
                     LHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSL
                     AGPHPGMGDAANHMGQM"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    890..>1375
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    2153..2407
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    2153..2407
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(2177..2179,2189..2191,2195..2203,2207..2209,
                     2222..2224,2285..2290)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2177..2179,2189..2191,2195..2203,2207..2209,
                     2222..2224,2285..2290)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2216..2221,2228..2233,2237..2242,2249..2251,
                     2261..2263,2291..2293,2300..2302,2312..2314,2321..2323,
                     2330..2347)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(2216..2221,2228..2233,2237..2242,2249..2251,
                     2261..2263,2291..2293,2300..2302,2312..2314,2321..2323,
                     2330..2347)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            560..632
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..694
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..791
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..853
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..983
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1033
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1139
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1270
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1403
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1471
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1550
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1627
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1831
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1967
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2118
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2348
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2489
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..7443
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ctccccagtc attgtctggt ggagcagccg cggccgcagc gccttctctt
       61 tataagccgc agtgcccgga tgtgaatgga ttacaatgta tctttcaggg aaacctatta
      121 ttatcaatgt gactcctcgg gggagtcaat gatggtgttg aggatgatga tgatgatgag
      181 acgcctctaa acttggaaca agtttaggac tttgaaagag aagaaaaaaa tacaaccaac
      241 aagaccgaag aacaattata actatcctgt gttgattatt ttttataaac aataagaaaa
      301 agttgtcgga ttttttttta tgattacttt tttgggggag gggattttgt ttcagtttta
      361 tgatggaaaa tgcaaaaacc agagccaagt gcataatctt gtaatctgtg gctaaccctg
      421 gaacaggact gactactatt taaaatactc ttttggggga atacacatgt gagatactaa
      481 gtacttgcag aagatttttg tctctctttt taaagtctct ttccttggaa tattgtgagc
      541 atatttgtgg ccattgaaga tgttttcgcc tcctgtaagc agtgggaaaa atggaccaac
      601 ttctttggcg agtggacatt ttacgggctc aaatgtagaa gacagaagta gctcagggtc
      661 ctgggggaat ggaggtcatc caagcccgtc caggaactat ggagatggga ctccctatga
      721 ccacatgact agcagggatc ttgggtcaca tgacaatctc tctccacctt ttgtcaattc
      781 cagaatacaa agtaaaacag aaaggggttc atactcatct tatgggagag aaaacgtaca
      841 gggttgccac cagcagagtc tcctcggagg ggacatggat atgggcaacc caggaaccct
      901 ttcgcccacc aaacctggct cccagtacta cccatattcc agcaataacg cccgacggag
      961 gcctcttcac agtagtacca tggaggtgca gacaaagaaa gtcagaaaag ttcctccagg
     1021 cttgccatct tcagtctacg ctccttcagc cagcactgcc gactacaaca gggactcacc
     1081 aggctattct tcctccaagc cagcagccag cactttctcc agctccttct tcatgcaaga
     1141 tggccatcac agcagtgacc cttggagctc ctccagtgga atgaatcagc ccggctatgg
     1201 agggatgcta ggcaactctc atatcccaca gtctagcagc tactgtagcc tgcatccaca
     1261 tgaacgtctg agctatccat cgcactcctc ggcagacatc aactccagtc ttcctccgat
     1321 gtccacgttc catcgaagtg gcacaaacca ttacagcacc tcttcctgca cacctcctgc
     1381 caacggaaca gacagtataa tggcaaacag aggaactggg gcagcaggca gctcccagac
     1441 tggagacgct ctggggaaag ccctggcttc gatctattct cctgatcaca cgaacaacag
     1501 cttctcctcc aacccttcaa ctcctgttgg ctcccctcct tcactctcag caggcacagc
     1561 tgtttggtct cgaaacggag gacaggcctc gtcatctccc aattacgaag gacccttgca
     1621 ctccttgcag agccgaattg aagaccgttt agaaagactg gacgacgcga ttcatgttct
     1681 ccggaaccac gcggtgggcc catccacagc tgtgcccggt ggccatgggg acatgcatgg
     1741 gatcatcgga ccctctcaca atggagcaat gggcagtctg ggctcaggat atggaactgg
     1801 ccttctctca gccaacagac attcactcat ggtcggggcc caccgtgaag atggcgtggc
     1861 actgagaggc agccattctc tcctgccaaa ccaggttccg gttccacagc ttccagtcca
     1921 gtctgcaact tcccctgact tgaacccacc ccaagaccct tacagaggga tgccaccagg
     1981 cctccaggga cagagtgtgt cttccggcag ctctgagatc aagtccgacg acgagggcga
     2041 tgagaaccta caggacacaa aatcttccga ggacaagaaa ctagacgacg acaagaagga
     2101 tatcaaatca attactagca ataacgatga tgaggacctg accccggagc agaaggccga
     2161 gcgtgagaag gagcggagga tggccaataa cgcccgtgag cgcctgaggg tccgtgatat
     2221 caacgaggct ttcaaggagc tgggccgcat ggtacagctc cacctgaaga gcgacaagcc
     2281 ccagaccaag ctcctgattc tccaccaggc agtggctgtc atcctcagcc tggagcagca
     2341 agtgcgagaa aggaacctga acccaaaagc tgcctgtctg aaaagaaggg aggaagagaa
     2401 ggtgtcctca gagcctcccc cgctctcctt ggctggccca caccctggga tgggagacgc
     2461 agcgaatcac atgggtcaga tgtgaaaggg tccaagttgc caccttgctt cattaaaaca
     2521 agagaccact tccttaacag ctgtattatc ctaaacccac ataaacactg ctccttaacc
     2581 ccgttttttt tgtaatataa gacaagtctg agtagttatg aatcgcagac gcaagaggtt
     2641 tcagcattcc caattatcaa aaaacagaaa aacaaacaca aaaaaaaaat gaatgaaaga
     2701 aagaaagaaa gagaaaatgc aacttgaggg acgacttctt taacatatca ctctgaatgt
     2761 gcgaagcggt atgtacaggc tgagacgcag cccagagact gaatggcaat ccttccacac
     2821 tgtggagcaa tgcatttgtg cctaaacttc ttttggaaaa aaaaatataa ttaatttgta
     2881 agtctgaaaa aaaatattta atttaaaaaa aattgtaaac ttgcaataat gaaaaagtgt
     2941 acttctgaag aaaaacgaca tgaacgtttt tgttggtatt caagtcagct agtgtttcta
     3001 attaccggat attgaataga ggaagcccgg ctaccctcat aacaaaacca gcaaccgtcc
     3061 tgatggcaac cgaaatgatg acattagcca ttccttaggg taggagggac agatggatgt
     3121 tatagaccta tgacaaatat atatataaat atatatataa atatatatta aaaatttagt
     3181 gactatggta agcttttgtt catttgtttc agactttttt ctcctgtaaa aaaatagtac
     3241 tgattaactt ttttaaaaga aagattttac tgtaaatatg gatttttttt tgtctgattt
     3301 ttgtcccttc ccccagtttg ttatcgtgac ctgtagtgcc aactctgctt ccggaggggc
     3361 agtgcaggac gaaatgctga ccctgatgtt gcttctcatt cataaatagt agaaagttgt
     3421 ttctccagtc ttttgggaac acaggactta aaagtcacat catgtgtaga aattacatgc
     3481 agcattgccc gggcaaggca aaaagagttt gtctggcttg tggcactgtg cttgttaccc
     3541 tctcctggga ttttcagagg tacacggtta gaatgctaca atgttaccac tgtgccttcc
     3601 aatgtttata tcatcggaaa catgacataa tcaaagtggc tgtgatttaa caaaaaaaaa
     3661 aaaagattca agtgttacct acctgtgtag cggaagtagt gtgcagtgag acgtttctga
     3721 atacatggtc agattttttt tggaaaaaat acaaaaacaa aaaaaaaaaa caaaaaaatt
     3781 taaaaaaaaa agtcaagttc aaaaaccgtc aaatgagaaa atcgcaagga gtgtgacagc
     3841 tgattgattt tgttgctttt cttgattttt ttttttttgt ttccaaatgg gtttactaaa
     3901 aagtacatga cttacctgcc tcctccttcg tctgaaaaca aaaaacaaaa aaacaatgcc
     3961 aacctatccc acagcattat agcaagcctt ataagcccta aagcattaag ttgcactttg
     4021 gtgaggaggg gtagcgcagt attctctctg gccagtatga gtgaagttta tacttaacat
     4081 ttgatagaaa catagatcaa actgtggcac agtaactcat cagatagcta gcgttgactc
     4141 tgggcacaat tgaaccaatt cccatcctaa atctttccaa caattgactt tggtgtacag
     4201 tgcagtgaac acatagaact cctacttaag tattcgtcag catccttttg tctctaactc
     4261 ggttctgttt tgacagccac acaatcttgg catgtattaa gtaaaaaaaa aaaaaaaatc
     4321 cctgttgaag tagttttccc acctatcagc actgagtaat tgccgtaact caatggaaat
     4381 ggtctaaacg ccccccatct cttgtcctgt accaccagtt acacagtgac aaaacacatc
     4441 tgtaaatttt atgcaaccaa tggcaaacct atcattattt tgaaactgtg tatgtaaaag
     4501 ttatattttt acatgtagac tcttgttatt atgtgtttta atacattgta tcagtttttt
     4561 gtttcctttt ttttttaact gtgtggtttt aaaaagtcat ttaaatgaaa tagcgagcta
     4621 caagaatctg aaatttatgt tcatttctga aaatgtaaga acaaataaga tagttatcac
     4681 gtggtcacct tttacaaacc catcgatgtt ttgactagct gtgtgtatgt gtgtgtgtgc
     4741 gcatgtgtgc gtgtgtgtgt atgtgtgttg aaaactgtaa atatgttcag tagcgataaa
     4801 acgacaatgc tttgatttgt tgagaagttc ctaaaatgtg gaggtggatt gaaaatgtag
     4861 gggaatagca gaaatcagat ttcatgaaga gctcttctct tcgggggctt tcctgtggaa
     4921 tggtcaaaca gaggtgctcc aagaagggca aggaagacag taacttcccc tcctccctga
     4981 acgacggaaa ccatgtgtac gtggtctctc accatgttaa agattttctt tccgtgatac
     5041 attctgcact ctttttgtat agtctaccaa ggcgggtatc cctgggaaca atattatgat
     5101 ataggaagca gtatactctg atcacattca ggagaattgt atagaagaga atatggtgtt
     5161 tactctttag ggaactggaa attctccctg cattgatgta catcttcaga gcggcccttt
     5221 tgatacacgt tatcataaag gtgctgacta aagcagaatt aaagtttttc aaatctgtaa
     5281 acaaagcaaa aaattaaatt acagtcattc gattgtttgt tttttttttt ttccaattgg
     5341 tgcttttata ttttgttctc actcagacag aaaaggctgc aatttcttgt tcaccagctt
     5401 tgatgtattc attactcggt aatgtaatac ggctattgtc aaattccttt tggaaataag
     5461 caaaaggctt ccccaaggcc tgcagcagct gctggctact ttctgcttgg cgcagaaaca
     5521 tgatctgacc ctctctgtag taatcgagtt gtatctccag ttttaaaaag aaggaaaaag
     5581 ggaatgtggc cgttttaatg tgtttttttt tttcttttct tgttgttatt ttgtaattct
     5641 caaacccagg taagatattg gtattcctgc actggatttt tgaaagaaac ttagcagaag
     5701 acaggatcga gatactatag aagcatttcc caagtgttca tactatacta gacataaatg
     5761 ataacggcga tgtataggtt caggatcggt ttaagagact cagactttga aagcaacttg
     5821 gaacggttga tccacctcca cattcgagta attaataatt ctgcagaatt agggatctgt
     5881 ccatctagga gttgttaccc atttgtcttc tgtgtggctg cgaggaacac taacgctttt
     5941 acaactgtca gttcacccag tggtacaact gattctgact cagtcttccg attcctgttt
     6001 tgtattttgt ttttccactt ttttcctatc tcttgatttt attgttgttg ttattgctat
     6061 tgttattatt attattcgtg atctttattt cgatgagggg ttgggaagtg ggagggagtc
     6121 gaactgagac taggggttga gaggattttt ttggtttggt tttcttttct tttttttttg
     6181 tttttttttt tttttgtttg tttgtttcat ctttgcgtcc aacaggcaga atatggtctg
     6241 tgtccaaaac ggaacttaag tcaggaagga aaccattcag cgtaaacaag cacaacatgt
     6301 agtctgtcgg ctgtctggaa gcaaaaataa attaataaat aaataataaa taagtaaaag
     6361 acacacacgg aggtgaagat gaaatgtgat ggattccgag acaatggggc accaaggcct
     6421 gtaggcctcc tcttgatttt gctttggtta tgtttgtttt ccttagagat gtttttttcc
     6481 tcacgggact tgaagtgact catctctgtg cagtaatggt ttcgccatat gctcatttca
     6541 agtattatag acatatgtaa tggtgaaata tatgaactgt ggcctttttc attcttgtta
     6601 tttgtgatgc aattaagtga agagaagaaa aaaaaaagca gagatttacc atgtatcagt
     6661 gcctggcttt ttgttataaa gcttcgtctg tctagtgctc tttttgctat aaaaatagac
     6721 tgtagtacac cctagtagga aaaaaaaacc ctaaatttaa aaataaaaaa atatatttgg
     6781 cttatttttc gcaggagcaa tccttttata ccatggatat tacaaaaaaa aaaattgtca
     6841 gattctgaat atttcttctt tgtagatttt tggaatcatt ataagtaaaa gtttgttact
     6901 ttattttact atttaaaaga tgttattttg ccatgtgtta ctgagatgaa actgtatggt
     6961 atagcttctt ctgttcgttt tttgtttccg gttttttgtt tgttcgtttt tggttttttt
     7021 tttttttgtt tgtttgtttt gttttgtttt tttttcttag ttgtaggtcg cagtaaggac
     7081 ttttcctttt gtttttgttt tttcgttatg ttttgttttg tttttgcgac tgtacacata
     7141 gctgcagcat taaaaacttt taaaaaaatc tgttaaaaaa aaaagaaaaa aaagggaaaa
     7201 cgtttaaaaa aaaaagataa acagttacac cttgttttca acgtgtggct gagtgcctcg
     7261 attttttcat gtttttggtg tatttctgat ttgtagaagt gtccaaacag gttgtgtcct
     7321 ggacttcctt caagaggcga acaacccagc ttggtctagg ccatgacctg ttcccatctg
     7381 tagttactcg atgaagtcat gtacatgacc gttctgtagc aataaatgtg ccatttttat
     7441 aaa
//
LOCUS       NM_001437018            2117 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 4, mRNA.
ACCESSION   NM_001437018 XM_063275349
VERSION     NM_001437018.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063275349.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1850297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680435
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-188             JAXUCZ010000016.1  6890885-6890926
            189-233             JAXUCZ010000016.1  6893598-6893642
            234-492             JAXUCZ010000016.1  6894275-6894533
            493-642             JAXUCZ010000016.1  6898222-6898371
            643-2117            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2117
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..188
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    187..189
                     /gene="Btd"
                     /note="upstream in-frame stop codon"
     exon            189..233
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1815
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; biotinase"
                     /codon_start=1
                     /product="biotinidase isoform 1 precursor"
                     /protein_id="NP_001423947.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MRRIFFPKRFTVCIMSGARTAHALVFLLGCSALALGVCSASLEH
                     GEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVF
                     PEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMF
                     LVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPAD
                     VDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEI
                     QKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQ
                     GLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY
                     DNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQAC
                     ALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWES
                     DHYFLRKRGLSSGLVTAALYGRLYERN"
     sig_peptide     208..318
                     /gene="Btd"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    355..1266
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    355..1266
                     /gene="Btd"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     Region: biotinidase_like; cd07567"
                     /db_xref="CDD:143591"
     misc_feature    order(517..519,817..819,829..831,835..837,916..921,
                     925..930,994..996)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(517..519,817..819,829..831,835..837,916..921,
                     925..930,994..996)
                     /gene="Btd"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(517..519,817..819,916..918)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(517..519,817..819,916..918)
                     /gene="Btd"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     misc_feature    order(820..834,853..861,919..921,925..939,946..951,
                     1012..1017,1021..1029,1033..1038,1108..1113,1252..1266)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    order(820..834,853..861,919..921,925..939,946..951,
                     1012..1017,1021..1029,1033..1038,1108..1113,1252..1266)
                     /gene="Btd"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:143591"
     misc_feature    1360..1809
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     misc_feature    1360..1809
                     /gene="Btd"
                     /note="Vanin C-terminal domain; Region: Vanin_C;
                     pfam19018"
                     /db_xref="CDD:465946"
     exon            234..492
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            493..642
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            643..2117
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagactc ttactggacc ttgggtcagt ggtgagactg
      181 attgactgaa aatcccatgt taccactatg agaaggattt tctttccaaa gcgatttacg
      241 gtctgcatta tgtctggagc ccgcactgcg catgcgctcg tcttcctcct cggctgttct
      301 gcgcttgcgt tgggcgtctg ctcagcctcc ctggagcacg gcgaggctga gtactacgtg
      361 gctgccgtgt acgaacaccg atcggtcctg agcccaaacc ccctggagct cagcagccgc
      421 cagcaggccc tggagctcat gaagcagaac ctcgacgtct atgaacagca agtgatggct
      481 gcagcccaga agggtgcgca cattatagtg ttcccagaag acggtatcca cggattcaac
      541 ttcacaagaa catccattta cccattcttg gacttgatgc catctcccag gctggtcagt
      601 tggaacccgt gtctggagcc ctttcgcttc aatgacacgg aggtcctcca gcgcctgagt
      661 tgcatggcca tcaagggaaa gatgttcttg gtggccaatc ttgggacaaa acagccttgc
      721 ctcggcagcg accctgggtg cccgcaggac gggagatacc agtttaacac aaacgtcgcg
      781 ttcagtgaca acggaaccct cgtcggccgc taccgtaagc acaacctgta ctttgaggaa
      841 gccttcgata gccctgctga cgtggacctc accacctttg atacgccgtt cgcgggcaag
      901 ttcggtatgt tcacttgctt tgatatcctg ttctttgacc ccgcggtccg gctcctcaga
      961 gactttgagg taaagcacat tgcgtaccct acggcctgga tgaaccagct gccgctcttg
     1021 gcagccattg aaatccagaa agcattcgcc accgccttcg gcgtcaccgt tctggcagct
     1081 aacatccacc acccgactct ggggatgacg ggcagtggca tacacacccc tctgaagtcc
     1141 ttttggtacc ataacatgga cgaccccgaa ggtcacctta taattgcccg ggtagccaca
     1201 aacccacagg gcctcgttgg gacagagaat acaactagtg aaatggatcc gtcccatagg
     1261 aagttcttaa aagtcttgtc tggggatccg tactgtgaga aggatgccca ggaagtgcgc
     1321 tgcgacgagg ctgccaagtg gaacctgaac gcaccaccta ccttccactc ggagatgatg
     1381 tatgacaatt tcaccctggt ccccgtctgg ggaaaggaag gccacctcca ggtgtgctcc
     1441 aacagtctct gttgccactt acttttcgag aggcccgccc tgtccaaaga gctatatgcc
     1501 ctgggtgtct ttgacggact ccacacagtg cacggtacct actacgttca agcctgtgcc
     1561 ctggtcaagt gcgggggcgc tggctttgaa acctgcgggc aggagatctc ggaggccgag
     1621 ggcttgtttg actttcatct gtgggggaac ttcagcacct tgtatgtctt ccctttattt
     1681 ctcacctcgg ggatgaccct agacacccct gaccagctcg ggtgggagag cgaccactat
     1741 ttcttgagga agaggggact gtcctccggc ctggtgacgg cagctctcta tgggcggttg
     1801 tatgagagga attaggaaaa ctgtggtcag caggttgggc tctgcaggct ggccttgcct
     1861 tcccacggcc cacagatccc aaacactggg aaaaccgccc cgcccctgtg gcactggatc
     1921 ccaccctggg gaactgtaag aagatgggag aggcagttcc tccttccttt ctacataatg
     1981 actgagatat tttctggtat tttctattca cattattctt tttcaagcca caccctctta
     2041 ccactactac acaattggtt ttaaagacta agccaaaaaa aaaaaaaaaa aataaacatc
     2101 agctgccatt ctacaaa
//
LOCUS       NM_001427183            3155 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus cylicin 2 (Cylc2), mRNA.
ACCESSION   NM_001427183 XM_008763719
VERSION     NM_001427183.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3155)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001427183.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1454343.1,
                                           SRR26643293.27809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000005.1  70349791-70349847
            58-98               JAXUCZ010000005.1  70354753-70354793
            99-220              JAXUCZ010000005.1  70356967-70357088
            221-2703            JAXUCZ010000005.1  70362358-70364840
            2704-2809           JAXUCZ010000005.1  70366027-70366132
            2810-2994           JAXUCZ010000005.1  70371567-70371751
            2995-3155           JAXUCZ010000005.1  70384583-70384743
FEATURES             Location/Qualifiers
     source          1..3155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q23"
     gene            1..3155
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="cylicin 2"
                     /db_xref="GeneID:500458"
                     /db_xref="RGD:1562799"
     exon            1..57
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1999
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="cylicin, basic protein of sperm head cytoskeleton
                     2"
                     /codon_start=1
                     /product="cylicin-2"
                     /protein_id="NP_001414112.1"
                     /db_xref="GeneID:500458"
                     /db_xref="RGD:1562799"
                     /translation="MSIPRFLKVTYGAYDNYIPVSELSKKSWNQQYFSLAFPKPPRPG
                     KKRRSLPSQLQNNPAPVIDEQKLGIHKPPLWMHRSLMRISERPSVYLAARKSLPPKPP
                     RFGKGEFKRAGTTKTLASEKSKKEVKLKKDECEAKEKKALKTEKEENLKPVDTKISKD
                     SQKDKGKISSGSEGEKAGVKKDVTTSKKGTKGTDSASETGSDKPGVKKDIKTSKKGTK
                     GTDSASESGNEKASGKKEAKTSKKGPKAKDSASETGSEKAGGKKEAKSSKKGLKAKES
                     ASDSGSEKAGGKKEAKSSKKGLKAKESASDSGSEKAGGKKGVKGSKKGLKAKESASDS
                     GSEKAGGKKGVKGSKKGSKAKDSASETGSEKAGGKKDAKASKKVSKDKSSASESGGEK
                     AGGKKEAKASKKVSKDKSSASESGGEKAGGKKEAKASKKVSKDKASPSESEVAKAGGK
                     KEAKASKKVSKDKVSASESGGEKAGGKKEAKASKKVSKDKVSASESDGEKSGGKKEAR
                     ASKKGSKDKASASESGGEKAGGKKEAKADKKSPKQSKETLVSKAVDKDVGKKEEKSVK
                     QGSKGKDVVADSASEKGDAGKEAKKKEEKEKKKKGEGDAKEGSKKEKKDKKDKKDKKD
                     KKDKKDKKDKKDKKEKKDKKEKKEKKAK"
     misc_feature    62..379
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="Cylicin N-terminus; Region: Cylicin_N; pfam15241"
                     /db_xref="CDD:464581"
     misc_feature    62..379
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="Cylicin N-terminus; Region: Cylicin_N; pfam15241"
                     /db_xref="CDD:464581"
     misc_feature    <362..1756
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <362..1756
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     exon            58..98
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     exon            99..220
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     exon            221..2703
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2809
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2994
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3155
                     /gene="Cylc2"
                     /gene_synonym="RGD1562799"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaccaaac ttaggccctg gcacgtcaca ggtggaagaa atgtctatac caagattcct
       61 aaaagtaaca tatggagcat acgataatta tattccagtc agtgaattaa gcaaaaaatc
      121 atggaatcag caatactttt ccctggcatt tcccaaacca ccaaggccag gaaagaaacg
      181 gagatcacta ccttcccagt tacagaacaa tccagctcct gtaattgatg aacaaaaatt
      241 aggaattcac aaaccaccat tatggatgca ccgttccctg atgagaatat ctgagagacc
      301 atcagtttat ttggctgcca ggaagagcct tccaccaaaa ccacctcgtt ttggcaaggg
      361 agagtttaaa agagcgggca caaccaagac tttggcttca gaaaaatcaa agaaagaagt
      421 gaaactgaaa aaagatgaat gtgaagcaaa agagaagaaa gctctaaaga cagagaagga
      481 agaaaatctc aaaccagttg atacaaaaat ttcaaaggat tcacagaagg acaagggaaa
      541 aatatcttca ggctctgaag gtgaaaaggc tggtgtgaag aaagatgtca cgaccagtaa
      601 aaaaggcaca aagggtactg attcagcctc agaaaccgga agtgacaagc ctggtgtgaa
      661 gaaagacatc aagaccagta aaaaaggcac aaagggtact gattcagcct cagaatctgg
      721 aaatgaaaag gctagtggga agaaggaagc caagaccagt aaaaaaggcc caaaggctaa
      781 agattcagcc tcagaaacag gaagtgaaaa ggctggtgga aaaaaggaag ccaagagcag
      841 taagaaaggc ttaaaggcta aagagtcagc ctcagacagc ggaagtgaaa aggctggtgg
      901 gaagaaggaa gccaagagca gtaagaaagg cttaaaggct aaagagtcag cctcagacag
      961 cggaagtgaa aaggctggtg ggaagaaggg agtcaagggc agtaagaaag gcttaaaggc
     1021 taaagagtca gcctcagaca gcggaagtga aaaggctggt gggaagaagg gagtcaaggg
     1081 cagtaagaaa ggctcaaagg ctaaagattc agcctcagaa accggaagtg agaaggctgg
     1141 tgggaagaag gacgccaagg caagtaaaaa ggtctcaaag gataaatctt cagcctcaga
     1201 atctggaggt gaaaaggctg gtggcaagaa ggaagccaag gcaagtaaaa aggtctcaaa
     1261 ggataaatct tcagcctcag aatctggagg tgaaaaggct ggtggcaaga aggaagccaa
     1321 ggcaagtaaa aaggtctcaa aggacaaagc ttctccctca gaatctgaag ttgcaaaggc
     1381 tggagggaag aaggaagcca aggcaagtaa gaaggtctca aaggacaaag tttctgcctc
     1441 agaatctgga ggtgaaaagg ctggagggaa gaaggaagcc aaggcaagta agaaggtctc
     1501 aaaggacaaa gtttctgcct cagaatctga cggtgaaaag tctggtggga agaaggaagc
     1561 cagggcaagt aaaaagggct caaaggacaa agcttctgcc tcagaatctg gaggtgaaaa
     1621 ggctggtggg aagaaggaag ccaaagcaga taaaaaaagc ccaaagcagt caaaagaaac
     1681 acttgtaagt aaagcagttg acaaagatgt tggaaagaaa gaagaaaagt cagttaaaca
     1741 gggttcaaaa ggcaaagatg tggttgcaga ttctgcaagt gaaaagggag atgcagggaa
     1801 agaggccaag aagaaggaag agaaagagaa aaagaaaaag ggagagggag atgcaaaaga
     1861 gggtagtaag aaagagaaga aagacaagaa ggacaagaag gacaagaagg acaaaaagga
     1921 caagaaggac aagaaggaca agaaagacaa gaaagaaaag aaagacaaga aagaaaagaa
     1981 agaaaagaag gcaaagtaag tcttggttca gaaagcaaac cgaaggtaag aactccaaag
     2041 catagtcagt gaacccattt tgatagtctt aacattcatc gtgagataaa agaagtatgc
     2101 aaagattaat caaaccattt attaaagaga aggaaaatta cacggtgaaa tgaaagtata
     2161 ctcatggaat taaaaagagg actaagaacg ttcataggat tcactgaacc atgtggaaga
     2221 tacccatttt aaatgtgtag ctatggaggt attaaagtaa aatcactagg gagattcaaa
     2281 gaatatataa ataagaatgc agaaaataac aattggaaaa caaacaacaa caaaaaaaac
     2341 cctacaatat tccataagga ttttgtttta aaggcttaca agaaggcttg gtgctgtgtc
     2401 tagctttaat gatgtgcagc tgagcttgta cacctatgaa gcacaatagc caagaaaagc
     2461 caaacaacgc ttagacaaca gaacttgaac tgaataaata tcaaaaaatg gcttcacaag
     2521 gaaaacaagt agaagagcag gaagagaggg aggggatgaa gagaaagatg gaaggaaaga
     2581 caagagagca aagatcaccg tccatacgaa aaaggaggaa ggacaccttg agtttgttta
     2641 caggaccatc tgagtttcaa gtgcccacaa tgacccacct gtcatccctg atgaacattt
     2701 ttggcatctt caattcaaaa tggccacaac agaacacttg atatgaccac caacgattgt
     2761 ttcacaaatc tcaattccgg aatctaagtc agggcctcat ctaaaggtga atgtgaaaag
     2821 aaaagaagat gatgaaatca aagagacaac atcagctctg gaaatgagaa gcaaaaaaac
     2881 ccccaacaaa caaaaacaaa aagaaaaaaa caacagaaat ttatgaaggt catttaagaa
     2941 gtacagcaga accctggcaa tgaagacgtt gtataatttt attcaaaatc tatggtatac
     3001 tatgaagaac tgttcaaaat tctcattatg gaagagtgca acgtttcatt ctcttgatta
     3061 tcttcatgtc tgtgaagttg tcaggcagct ctaattttga aatgaatgaa ttttaacatc
     3121 agatgaaaac atccattaaa acatttcttc atgga
//
LOCUS       NM_001437096            7000 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            20, mRNA.
ACCESSION   NM_001437096 XM_039097191
VERSION     NM_001437096.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7000)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7000)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7000)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7000)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7000)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7000)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7000)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7000)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7000)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7000)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097191.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.419797.1,
                                           SRR26643429.54622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-578               JAXUCZ010000018.1  65468033-65468610
            579-684             JAXUCZ010000018.1  65507173-65507278
            685-815             JAXUCZ010000018.1  65511025-65511155
            816-948             JAXUCZ010000018.1  65516916-65517048
            949-1016            JAXUCZ010000018.1  65525175-65525242
            1017-1095           JAXUCZ010000018.1  65526319-65526397
            1096-1172           JAXUCZ010000018.1  65528841-65528917
            1173-1376           JAXUCZ010000018.1  65531547-65531750
            1377-1512           JAXUCZ010000018.1  65551334-65551469
            1513-1675           JAXUCZ010000018.1  65553405-65553567
            1676-1905           JAXUCZ010000018.1  65556812-65557041
            1906-2046           JAXUCZ010000018.1  65557878-65558018
            2047-7000           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7000
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..578
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    558..560
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            579..684
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             678..2042
                     /gene="Tcf4"
                     /note="isoform 20 is encoded by transcript variant 20;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 20"
                     /protein_id="NP_001424025.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHE
                     RLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQ
                     TGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEG
                     PLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGS
                     GYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDP
                     YRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSN
                     NDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLL
                     ILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANH
                     MGQM"
     misc_feature    1710..1964
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1710..1964
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1734..1736,1746..1748,1752..1760,1764..1766,
                     1779..1781,1842..1847)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1734..1736,1746..1748,1752..1760,1764..1766,
                     1779..1781,1842..1847)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1773..1778,1785..1790,1794..1799,1806..1808,
                     1818..1820,1848..1850,1857..1859,1869..1871,1878..1880,
                     1887..1904)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1773..1778,1785..1790,1794..1799,1806..1808,
                     1818..1820,1848..1850,1857..1859,1869..1871,1878..1880,
                     1887..1904)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            685..815
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..948
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1016
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1095
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1172
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1376
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1512
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1675
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1905
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2046
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..7000
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgggaaa atgcaactga aggaattgtt gtgaaaaaag ggacagcgag tttgaaataa
       61 aagttgttag agtggtactg aggagaaaaa agaatccgag gccatgtact gcgcatacac
      121 catcccgggc atgggcggca actctttgat gtactactat aatgggaaag cggtaagcga
      181 actcgggctg cgaggggcat tggggacaag ttttatggtc acagggatga gccttctagg
      241 cggggagcat tgtttgcgaa gttgtgcagg actgccgcac ctttctcggt gccatgaaat
      301 atttatcatc tgcgagtcct aggatgtttc cgttgccttc ttgctttttg ccttcccctc
      361 agtagggaac catcaaagct ttacaaagct cctgaaaagt agatcccaga gagaaaagtt
      421 tgcagtcagg tgaacttagg aggttgtacg atttaaaata atactaattt taaaaggatt
      481 tttggcaaaa atcctttttg cttttcaaat gattggaagg aggagcagat tatgaagaga
      541 accgagaaag cccaagttag cctgagagaa aattgggggt ctacgctcct tcagccagca
      601 ctgccgacta caacagggac tcaccaggct attcttcctc caagccagca gccagcactt
      661 tctccagctc cttcttcatg caagatggcc atcacagcag tgacccttgg agctcctcca
      721 gtggaatgaa tcagcccggc tatggaggga tgctaggcaa ctctcatatc ccacagtcta
      781 gcagctactg tagcctgcat ccacatgaac gtctgagcta tccatcgcac tcctcggcag
      841 acatcaactc cagtcttcct ccgatgtcca cgttccatcg aagtggcaca aaccattaca
      901 gcacctcttc ctgcacacct cctgccaacg gaacagacag tataatggca aacagaggaa
      961 ctggggcagc aggcagctcc cagactggag acgctctggg gaaagccctg gcttcgatct
     1021 attctcctga tcacacgaac aacagcttct cctccaaccc ttcaactcct gttggctccc
     1081 ctccttcact ctcagcaggc acagctgttt ggtctcgaaa cggaggacag gcctcgtcat
     1141 ctcccaatta cgaaggaccc ttgcactcct tgcagagccg aattgaagac cgtttagaaa
     1201 gactggacga cgcgattcat gttctccgga accacgcggt gggcccatcc acagctgtgc
     1261 ccggtggcca tggggacatg catgggatca tcggaccctc tcacaatgga gcaatgggca
     1321 gtctgggctc aggatatgga actggccttc tctcagccaa cagacattca ctcatggtcg
     1381 gggcccaccg tgaagatggc gtggcactga gaggcagcca ttctctcctg ccaaaccagg
     1441 ttccggttcc acagcttcca gtccagtctg caacttcccc tgacttgaac ccaccccaag
     1501 acccttacag agggatgcca ccaggcctcc agggacagag tgtgtcttcc ggcagctctg
     1561 agatcaagtc cgacgacgag ggcgatgaga acctacagga cacaaaatct tccgaggaca
     1621 agaaactaga cgacgacaag aaggatatca aatcaattac taggtcaaga tctagcaata
     1681 acgatgatga ggacctgacc ccggagcaga aggccgagcg tgagaaggag cggaggatgg
     1741 ccaataacgc ccgtgagcgc ctgagggtcc gtgatatcaa cgaggctttc aaggagctgg
     1801 gccgcatggt acagctccac ctgaagagcg acaagcccca gaccaagctc ctgattctcc
     1861 accaggcagt ggctgtcatc ctcagcctgg agcagcaagt gcgagaaagg aacctgaacc
     1921 caaaagctgc ctgtctgaaa agaagggagg aagagaaggt gtcctcagag cctcccccgc
     1981 tctccttggc tggcccacac cctgggatgg gagacgcagc gaatcacatg ggtcagatgt
     2041 gaaagggtcc aagttgccac cttgcttcat taaaacaaga gaccacttcc ttaacagctg
     2101 tattatccta aacccacata aacactgctc cttaaccccg ttttttttgt aatataagac
     2161 aagtctgagt agttatgaat cgcagacgca agaggtttca gcattcccaa ttatcaaaaa
     2221 acagaaaaac aaacacaaaa aaaaaatgaa tgaaagaaag aaagaaagag aaaatgcaac
     2281 ttgagggacg acttctttaa catatcactc tgaatgtgcg aagcggtatg tacaggctga
     2341 gacgcagccc agagactgaa tggcaatcct tccacactgt ggagcaatgc atttgtgcct
     2401 aaacttcttt tggaaaaaaa aatataatta atttgtaagt ctgaaaaaaa atatttaatt
     2461 taaaaaaaat tgtaaacttg caataatgaa aaagtgtact tctgaagaaa aacgacatga
     2521 acgtttttgt tggtattcaa gtcagctagt gtttctaatt accggatatt gaatagagga
     2581 agcccggcta ccctcataac aaaaccagca accgtcctga tggcaaccga aatgatgaca
     2641 ttagccattc cttagggtag gagggacaga tggatgttat agacctatga caaatatata
     2701 tataaatata tatataaata tatattaaaa atttagtgac tatggtaagc ttttgttcat
     2761 ttgtttcaga cttttttctc ctgtaaaaaa atagtactga ttaacttttt taaaagaaag
     2821 attttactgt aaatatggat ttttttttgt ctgatttttg tcccttcccc cagtttgtta
     2881 tcgtgacctg tagtgccaac tctgcttccg gaggggcagt gcaggacgaa atgctgaccc
     2941 tgatgttgct tctcattcat aaatagtaga aagttgtttc tccagtcttt tgggaacaca
     3001 ggacttaaaa gtcacatcat gtgtagaaat tacatgcagc attgcccggg caaggcaaaa
     3061 agagtttgtc tggcttgtgg cactgtgctt gttaccctct cctgggattt tcagaggtac
     3121 acggttagaa tgctacaatg ttaccactgt gccttccaat gtttatatca tcggaaacat
     3181 gacataatca aagtggctgt gatttaacaa aaaaaaaaaa agattcaagt gttacctacc
     3241 tgtgtagcgg aagtagtgtg cagtgagacg tttctgaata catggtcaga ttttttttgg
     3301 aaaaaataca aaaacaaaaa aaaaaaacaa aaaaatttaa aaaaaaaagt caagttcaaa
     3361 aaccgtcaaa tgagaaaatc gcaaggagtg tgacagctga ttgattttgt tgcttttctt
     3421 gatttttttt tttttgtttc caaatgggtt tactaaaaag tacatgactt acctgcctcc
     3481 tccttcgtct gaaaacaaaa aacaaaaaaa caatgccaac ctatcccaca gcattatagc
     3541 aagccttata agccctaaag cattaagttg cactttggtg aggaggggta gcgcagtatt
     3601 ctctctggcc agtatgagtg aagtttatac ttaacatttg atagaaacat agatcaaact
     3661 gtggcacagt aactcatcag atagctagcg ttgactctgg gcacaattga accaattccc
     3721 atcctaaatc tttccaacaa ttgactttgg tgtacagtgc agtgaacaca tagaactcct
     3781 acttaagtat tcgtcagcat ccttttgtct ctaactcggt tctgttttga cagccacaca
     3841 atcttggcat gtattaagta aaaaaaaaaa aaaaatccct gttgaagtag ttttcccacc
     3901 tatcagcact gagtaattgc cgtaactcaa tggaaatggt ctaaacgccc cccatctctt
     3961 gtcctgtacc accagttaca cagtgacaaa acacatctgt aaattttatg caaccaatgg
     4021 caaacctatc attattttga aactgtgtat gtaaaagtta tatttttaca tgtagactct
     4081 tgttattatg tgttttaata cattgtatca gttttttgtt tccttttttt tttaactgtg
     4141 tggttttaaa aagtcattta aatgaaatag cgagctacaa gaatctgaaa tttatgttca
     4201 tttctgaaaa tgtaagaaca aataagatag ttatcacgtg gtcacctttt acaaacccat
     4261 cgatgttttg actagctgtg tgtatgtgtg tgtgtgcgca tgtgtgcgtg tgtgtgtatg
     4321 tgtgttgaaa actgtaaata tgttcagtag cgataaaacg acaatgcttt gatttgttga
     4381 gaagttccta aaatgtggag gtggattgaa aatgtagggg aatagcagaa atcagatttc
     4441 atgaagagct cttctcttcg ggggctttcc tgtggaatgg tcaaacagag gtgctccaag
     4501 aagggcaagg aagacagtaa cttcccctcc tccctgaacg acggaaacca tgtgtacgtg
     4561 gtctctcacc atgttaaaga ttttctttcc gtgatacatt ctgcactctt tttgtatagt
     4621 ctaccaaggc gggtatccct gggaacaata ttatgatata ggaagcagta tactctgatc
     4681 acattcagga gaattgtata gaagagaata tggtgtttac tctttaggga actggaaatt
     4741 ctccctgcat tgatgtacat cttcagagcg gcccttttga tacacgttat cataaaggtg
     4801 ctgactaaag cagaattaaa gtttttcaaa tctgtaaaca aagcaaaaaa ttaaattaca
     4861 gtcattcgat tgtttgtttt tttttttttc caattggtgc ttttatattt tgttctcact
     4921 cagacagaaa aggctgcaat ttcttgttca ccagctttga tgtattcatt actcggtaat
     4981 gtaatacggc tattgtcaaa ttccttttgg aaataagcaa aaggcttccc caaggcctgc
     5041 agcagctgct ggctactttc tgcttggcgc agaaacatga tctgaccctc tctgtagtaa
     5101 tcgagttgta tctccagttt taaaaagaag gaaaaaggga atgtggccgt tttaatgtgt
     5161 tttttttttt cttttcttgt tgttattttg taattctcaa acccaggtaa gatattggta
     5221 ttcctgcact ggatttttga aagaaactta gcagaagaca ggatcgagat actatagaag
     5281 catttcccaa gtgttcatac tatactagac ataaatgata acggcgatgt ataggttcag
     5341 gatcggttta agagactcag actttgaaag caacttggaa cggttgatcc acctccacat
     5401 tcgagtaatt aataattctg cagaattagg gatctgtcca tctaggagtt gttacccatt
     5461 tgtcttctgt gtggctgcga ggaacactaa cgcttttaca actgtcagtt cacccagtgg
     5521 tacaactgat tctgactcag tcttccgatt cctgttttgt attttgtttt tccacttttt
     5581 tcctatctct tgattttatt gttgttgtta ttgctattgt tattattatt attcgtgatc
     5641 tttatttcga tgaggggttg ggaagtggga gggagtcgaa ctgagactag gggttgagag
     5701 gatttttttg gtttggtttt cttttctttt ttttttgttt tttttttttt ttgtttgttt
     5761 gtttcatctt tgcgtccaac aggcagaata tggtctgtgt ccaaaacgga acttaagtca
     5821 ggaaggaaac cattcagcgt aaacaagcac aacatgtagt ctgtcggctg tctggaagca
     5881 aaaataaatt aataaataaa taataaataa gtaaaagaca cacacggagg tgaagatgaa
     5941 atgtgatgga ttccgagaca atggggcacc aaggcctgta ggcctcctct tgattttgct
     6001 ttggttatgt ttgttttcct tagagatgtt tttttcctca cgggacttga agtgactcat
     6061 ctctgtgcag taatggtttc gccatatgct catttcaagt attatagaca tatgtaatgg
     6121 tgaaatatat gaactgtggc ctttttcatt cttgttattt gtgatgcaat taagtgaaga
     6181 gaagaaaaaa aaaagcagag atttaccatg tatcagtgcc tggctttttg ttataaagct
     6241 tcgtctgtct agtgctcttt ttgctataaa aatagactgt agtacaccct agtaggaaaa
     6301 aaaaacccta aatttaaaaa taaaaaaata tatttggctt atttttcgca ggagcaatcc
     6361 ttttatacca tggatattac aaaaaaaaaa attgtcagat tctgaatatt tcttctttgt
     6421 agatttttgg aatcattata agtaaaagtt tgttacttta ttttactatt taaaagatgt
     6481 tattttgcca tgtgttactg agatgaaact gtatggtata gcttcttctg ttcgtttttt
     6541 gtttccggtt ttttgtttgt tcgtttttgg tttttttttt ttttgtttgt ttgttttgtt
     6601 ttgttttttt ttcttagttg taggtcgcag taaggacttt tccttttgtt tttgtttttt
     6661 cgttatgttt tgttttgttt ttgcgactgt acacatagct gcagcattaa aaacttttaa
     6721 aaaaatctgt taaaaaaaaa agaaaaaaaa gggaaaacgt ttaaaaaaaa aagataaaca
     6781 gttacacctt gttttcaacg tgtggctgag tgcctcgatt ttttcatgtt tttggtgtat
     6841 ttctgatttg tagaagtgtc caaacaggtt gtgtcctgga cttccttcaa gaggcgaaca
     6901 acccagcttg gtctaggcca tgacctgttc ccatctgtag ttactcgatg aagtcatgta
     6961 catgaccgtt ctgtagcaat aaatgtgcca tttttataaa
//
LOCUS       NM_001108684            5324 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 4, mRNA.
ACCESSION   NM_001108684 XM_001063603 XM_342928
VERSION     NM_001108684.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5324)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5324)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5324)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5324)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5324)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5324)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5324)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5324)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5324)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5324)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001108684.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.22932.1,
                                           SRR26643299.24531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1470           JAXUCZ010000005.1  148197677-148197781
            1471-1622           JAXUCZ010000005.1  148200975-148201126
            1623-1761           JAXUCZ010000005.1  148203568-148203706
            1762-1905           JAXUCZ010000005.1  148205552-148205695
            1906-2202           JAXUCZ010000005.1  148206678-148206974
            2203-2439           JAXUCZ010000005.1  148208059-148208295
            2440-2707           JAXUCZ010000005.1  148218465-148218732
            2708-2837           JAXUCZ010000005.1  148219783-148219912
            2838-2972           JAXUCZ010000005.1  148221617-148221751
            2973-3110           JAXUCZ010000005.1  148225153-148225290
            3111-3236           JAXUCZ010000005.1  148228732-148228857
            3237-3358           JAXUCZ010000005.1  148229514-148229635
            3359-3551           JAXUCZ010000005.1  148231206-148231398
            3552-5324           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5324
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3683
                     /gene="Pum1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 4"
                     /protein_id="NP_001102154.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAA
                     TLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGG
                     ASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGAL
                     VVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPL
                     GTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSL
                     GATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSS
                     SPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRS
                     ASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIME
                     FSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQ
                     KLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGHVLKCVKDQN
                     GNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
                     ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKC
                     VTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHK
                     IRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2643..3614
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2643..3614
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2811..2816,2823..2825,2919..2924,2931..2933,
                     3036..3038,3045..3047,3141..3146,3153..3155,3240..3245,
                     3249..3254,3261..3263,3348..3353,3357..3362,3369..3371,
                     3477..3482,3486..3491,3498..3500,3588..3590,3597..3599)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2811..2816,2823..2825,2919..2924,2931..2933,
                     3036..3038,3045..3047,3141..3146,3153..3155,3240..3245,
                     3249..3254,3261..3263,3348..3353,3357..3362,3369..3371,
                     3477..3482,3486..3491,3498..3500,3588..3590,3597..3599)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1470
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1622
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1761
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1905
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2202
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2439
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2707
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2837
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2972
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3110
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3236
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3358
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3551
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..5324
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcgcaggt ttagctcccg
     1381 ctgcgtttgt ccccaaccca tacatcatca gcgctgctcc cccagggacg gacccctaca
     1441 cagctggatt ggctgcagca gcgacactcg gcccagctgt ggtccctcac caatattatg
     1501 gagtcacgcc atggggtgtc tatcctgcta gtcttttcca gcaacaagct gctgcagctg
     1561 cagcagcaac aaattcagct actcagcaga gtgccccaca ggcccagcag ggacagcagc
     1621 aggttcttcg tggaggagct agccagcgtc ctttgacccc aaatcagaac cagcagggac
     1681 aacaaacaga tccccttgta gcagctgcag cagtgaactc tgctcttgcc tttggacaag
     1741 gattggctgc aggtatgcca ggttatccag tcttggcacc tgctgcttac tatgaccaaa
     1801 ctggtgccct tgtggtgaat gcaggggcaa gaaatggcct cggagctcca gttcggcttg
     1861 ttgctccagc cccagtcatc attagctcct cagctgcaca agcagctgtt gcagcggctg
     1921 cagcttcagc aaatggagca gccggtggtc ttgcaggaac tacaaatgga ccatttcgac
     1981 ctttaggcac ccagcagccc cagccccagc cccagcagca gcccagtaac aatctggctt
     2041 ccagctcttt ctatggcaac aactctctga gcagtaactc ccagagcagc tccctcttct
     2101 ctcagggctc cgcccagcct gccaacacgt ccttgggatt cggaagcagc agttcccttg
     2161 gtgccaccct aggatcggcc cttggagggt ttggaacagc agttgcaaac tccaacactg
     2221 gcagtggctc ccgccgtgac tccctgactg gcagcagtga cctttataag aggacatcga
     2281 gcagcttggc ccccattgga cacagttttt ataacagcct tagcttttcc tcctctcctg
     2341 gacccgtggg catgcctctc cctagtcagg gaccaggaca ttcacagaca ccacctcctt
     2401 ccctctcttc acatggatcc tcttcaagct taaacctggg aggactcacg aacggcagtg
     2461 gaagatacat ctctgctgct cctggtgccg aagccaagta ccgcagtgcg agcagtgcct
     2521 ccagcctttt cagccccagc agcacccttt tttcttcctc tcgtttgaga tacggaatgt
     2581 ctgatgttat gccctctggc aggagcagac ttctggaaga ctttcgaaac aaccggtacc
     2641 ctaatttaca actgcgggag attgccgggc atataatgga attttcccaa gaccagcatg
     2701 gttctagatt cattcagctg aaactagagc gagccacagc agctgagcgc cagcttgtct
     2761 tcaacgaaat cctgcaggct gcgtaccaac ttatggtgga tgtgtttgga aattacgtca
     2821 ttcagaagtt ctttgaattt ggcagccatg aacagaagct ggctttggct gaacggattc
     2881 gaggccacgt cctatcattg gcactgcaga tgtatggctg ccgagtcatc cagaaagctt
     2941 tggaatttat tccctcagac cagcaggtaa ttaacgagat ggtgcgggag ctagatggcc
     3001 atgtcctgaa gtgtgtgaaa gaccagaatg gcaaccatgt ggttcagaag tgcattgaat
     3061 gtgtacagcc ccagtctttg cagttcatca tcgatgcatt caaggggcag gtgtttgctt
     3121 tgtctacgca cccatatggc tgtagggtga tccagaggat cctggaacac tgtctccccg
     3181 accagaccct ccctatcctg gaggagcttc accagcacac ggagcagctc gtgcaggatc
     3241 agtatggaaa ttatgtaatc caacatgtcc tggagcatgg tcgtcctgag gataaaagca
     3301 aaattgtagc agagatccga ggcaatgtac ttgtattgag tcagcacaaa ttcgcaagca
     3361 atgttgtgga gaagtgtgtc actcacgcct cacgtacaga gcgtgctgtg ctcattgatg
     3421 aggtatgcac catgaatgac ggtccccaca gtgccttata caccatgatg aaggatcagt
     3481 atgccaatta tgtggtccag aagatgatcg atgtggctga gccggggcag cggaagattg
     3541 tcatgcacaa gatccggcca cacatcgcga ctcttcggaa gtacacctat ggcaagcaca
     3601 tcctggccaa gcttgagaag tactacatga agaatggtgt ggacttgggg cccatttgtg
     3661 gtccccctaa tgggatcatc tgagcagtgc acccatccct gtcccgctga cctcactgac
     3721 cctggcagat ccaaccagca accagagatg cccagctcag agtcgaaagt gggcgatggt
     3781 tgctccggga ttgctccctc ctccaaaaat ggaatcggat ccacttgtgg aaaggccttt
     3841 gtaaatttca ttttattaca cataacatgt actaattatt ttttttaatt gactaattgc
     3901 cctgctgttt actggtgtat aggaacttgt acataggtaa tcagtgtaca tgagaggcca
     3961 catgctttgt tcaatgttgt atctatattc cacatgtgga cactttcagg gtggttggtt
     4021 taacaaaaaa agttttaaaa aaagacaaaa aaaggttttt aactcatttg ccttgtggca
     4081 agttttgcaa atagctcttc cccaccccat tttattaaaa aaagaaacct gagaaatttg
     4141 aattttagtt aaataatctc aaactggcat ttaacactgt ttataaaata tatatatata
     4201 tatacatata tacatatgaa atgggaacgt ttccgagttg ctaaagcatc agcctgtgat
     4261 acggagttta tgacgctctt tggagatgac ctcatgctga gggaggtggt agctgcagat
     4321 ccaggaggag cgggaagcac agagacaggc cggaggccag tgggcatggc cacttgctct
     4381 atgggttgcc ttctgtgaac actgggaagc agaatctgat tatctagcat gagagaaccc
     4441 agctctgctc ctggtctggc ttctatagat acatagtgta tacttgtgta gactttgcat
     4501 atatacggat ttgtagtatt ttcctgtttt gatgtctaat ctgtatctat aatgtaccct
     4561 agtagtcgga catacttttg attgtacaat tgtacatttg tatacctgta atgtaaatgt
     4621 ggagaagttt gaatcaacat gaacacgttt ttggtaagaa gagaaccggc cagcccgtgc
     4681 actctgtata tcccaccttt tatggttgta gcagatagtg ttgtatattg taaattgtaa
     4741 tttcaaacag aagtaaattt ttttcttttg aaggaataaa tgttctttat acagcctagt
     4801 taatgtttaa aaagaaaaaa tagcttggtt tatttgtcag ctagtcaaga cggtagtgag
     4861 agcctttcta aatgttactt cagatgattc agttcacact agtgttcctt tttttttttt
     4921 tatcctaaga aaaggtaatg tttcgcttat tttgtgacag tcaaaaggat gtgcagaagt
     4981 ttcgcctgcc ccttccctgc tcaccacctc cccttgtaaa gtgactcacc ctccgttttg
     5041 tacagatgag ctgtattttg cattttgtct acttgtaagt gaatgtaaca tactgtcaat
     5101 cctcgtttga atatagactg taacactaca cggtgtacat ttccagagcc ttgtgtatat
     5161 ttccaatgaa ctttttgcaa gcacacttgt aaccatatgt gtataattaa caaacctgtg
     5221 tatgcttatg cctgggcaac tattttttgt aactcttgtg tagattgtct ctaaacaatg
     5281 tgtgatcttt attttgaaaa aaatacagaa ctttggaatc tgaa
//
LOCUS       NM_001105951            7918 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 3-kinase,
            catalytic subunit type 2 beta (Pik3c2b), transcript variant 2,
            mRNA.
ACCESSION   NM_001105951 XM_001060466 XM_213879
VERSION     NM_001105951.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7918)
  AUTHORS   Kozhevnikova,O.S., Telegina,D.V., Devyatkin,V.A. and Kolosova,N.G.
  TITLE     Involvement of the autophagic pathway in the progression of
            AMD-like retinopathy in senescence-accelerated OXYS rats
  JOURNAL   Biogerontology 19 (3-4), 223-235 (2018)
   PUBMED   29492791
  REMARK    GeneRIF: Missense single-nucleotide polymorphism in the Pik3c2b
            gene associated with autophagy regulation in in the progression of
            Age-related macular degeneration was found.
REFERENCE   2  (bases 1 to 7918)
  AUTHORS   Devereaux,K., Dall'Armi,C., Alcazar-Roman,A., Ogasawara,Y.,
            Zhou,X., Wang,F., Yamamoto,A., De Camilli,P. and Di Paolo,G.
  TITLE     Regulation of mammalian autophagy by class II and III PI 3-kinases
            through PI3P synthesis
  JOURNAL   PLoS One 8 (10), e76405 (2013)
   PUBMED   24098492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7918)
  AUTHORS   Das,M., Scappini,E., Martin,N.P., Wong,K.A., Dunn,S., Chen,Y.J.,
            Miller,S.L., Domin,J. and O'Bryan,J.P.
  TITLE     Regulation of neuron survival through an
            intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway
  JOURNAL   Mol Cell Biol 27 (22), 7906-7917 (2007)
   PUBMED   17875942
REFERENCE   4  (bases 1 to 7918)
  AUTHORS   Sindic,A., Crljen,V., Matkovic,K., Lukinovic-Skudar,V., Visnjic,D.
            and Banfic,H.
  TITLE     Activation of phosphoinositide 3-kinase C2 beta in the nuclear
            matrix during compensatory liver growth
  JOURNAL   Adv Enzyme Regul 46, 280-287 (2006)
   PUBMED   16857245
  REMARK    GeneRIF: Activated during compensatory liver growth, which clearly
            demonstrates that different class II PI3K enzymes have different
            subnuclear localization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001105951.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               JAXUCZ010000013.1  47047074-47047506
            434-1457            JAXUCZ010000013.1  47066101-47067124
            1458-1558           JAXUCZ010000013.1  47070150-47070250
            1559-1713           JAXUCZ010000013.1  47071019-47071173
            1714-1834           JAXUCZ010000013.1  47071452-47071572
            1835-1946           JAXUCZ010000013.1  47074701-47074812
            1947-2026           JAXUCZ010000013.1  47074965-47075044
            2027-2090           JAXUCZ010000013.1  47075674-47075737
            2091-2237           JAXUCZ010000013.1  47077131-47077277
            2238-2431           JAXUCZ010000013.1  47079707-47079900
            2432-2554           JAXUCZ010000013.1  47081111-47081233
            2555-2722           JAXUCZ010000013.1  47085022-47085189
            2723-2834           JAXUCZ010000013.1  47085718-47085829
            2835-2977           JAXUCZ010000013.1  47087142-47087284
            2978-3166           JAXUCZ010000013.1  47088397-47088585
            3167-3260           JAXUCZ010000013.1  47090048-47090141
            3261-3355           JAXUCZ010000013.1  47090263-47090357
            3356-3536           JAXUCZ010000013.1  47090764-47090944
            3537-3644           JAXUCZ010000013.1  47091658-47091765
            3645-3737           JAXUCZ010000013.1  47092398-47092490
            3738-3867           JAXUCZ010000013.1  47092799-47092928
            3868-4004           JAXUCZ010000013.1  47093850-47093986
            4005-4174           JAXUCZ010000013.1  47097827-47097996
            4175-4331           JAXUCZ010000013.1  47098327-47098483
            4332-4441           JAXUCZ010000013.1  47098812-47098921
            4442-4643           JAXUCZ010000013.1  47100258-47100459
            4644-4768           JAXUCZ010000013.1  47100850-47100974
            4769-4886           JAXUCZ010000013.1  47101747-47101864
            4887-4968           JAXUCZ010000013.1  47102626-47102707
            4969-5075           JAXUCZ010000013.1  47103003-47103109
            5076-5204           JAXUCZ010000013.1  47104171-47104299
            5205-7918           JAXUCZ010000013.1  47105020-47107733
FEATURES             Location/Qualifiers
     source          1..7918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..7918
                     /gene="Pik3c2b"
                     /note="phosphatidylinositol-4-phosphate 3-kinase,
                     catalytic subunit type 2 beta"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
     exon            1..433
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1457
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    486..488
                     /gene="Pik3c2b"
                     /note="upstream in-frame stop codon"
     CDS             528..5393
                     /gene="Pik3c2b"
                     /EC_number="2.7.1.154"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphoinositide-3-kinase, class 2, beta polypeptide;
                     nuclear cap binding protein subunit 2;
                     phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta isoform 2"
                     /protein_id="NP_001099421.1"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
                     /translation="MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK
                     EESRAKQNTEPSLISWDEPALDFYSKPAGRRTELKLLRGLSGSDPTLNYNSISPPEEL
                     PNSTSQDPQPGTDPWPKGSQSGDYLYIFDGSDGRCSLSPVSGDTDGSCKKLSPPPLPP
                     RVSIWDAPPLPPRKGSPSPSKISQPDDINSFSLVEQPSDKLLGAQDPGEGELPNGGGQ
                     RHVLGSVDYDGINDAITRLNLKSTYDSEILSDATRGWKEGRGPLDFSKDTSGKPVARS
                     KTMPPQVPPRTYTPRYANRKNATPGKNRRISAAPVSSRTHTVTNGHELFEVSEERDEE
                     VAAFCHMLDILRTGSDTQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTF
                     TCNCSSTVDLLIYQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCR
                     KFDINIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFD
                     TYHNEVDAFLLAEGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQP
                     KIQKKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFSGALAFTVYG
                     THRIPIIWATSYEEFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFPVQ
                     VNRLPRETLLCATLYALPIPPPGSSSEANKQKRVPEALGWVTTPLFNFRQVLTCGRKL
                     LGLWPATQENSSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSL
                     REEDQRKLKDITQKESLYWLSDADKKQLWEKRYYCHTEVSSLPLVLASAPSWEWACLP
                     DIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALK
                     YECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQYLLAALLCCCGKG
                     LREEFNRQCWLVNTLAKLAQQVREATPSARQGILRAGLEEVRQFFALNGSCRLPLSPS
                     LLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIM
                     SKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADW
                     LQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRF
                     LGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLF
                     LNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNF
                     FIHNLAQMKFTGSDDRLTLSFAPRTHTLKSSGRIRDVFLCRHEKVFHPSKGYIYVVKV
                     MRENAHEATYIQRTFEEFQELHNKLRLLFPSSFLPSFPSRFVIGRSRGEAVAERRKEE
                     LNGYIWHLIHAAPEVAECDLVYTFFHPLPRDEKTSGPSPAPKSSDGTWARPVGKVGGE
                     VKLSISYKNNKLFIMVMHIRGLQPLQDGSDPDPYVKIYLLPDPQKATKRKTKVARKTC
                     NPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVHIRLRELDLAQEKTGW
                     FALGSRGHGTL"
     misc_feature    1614..1922
                     /gene="Pik3c2b"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1614..1922
                     /gene="Pik3c2b"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    2352..2870
                     /gene="Pik3c2b"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2A_PI3K_class_II; cd04012"
                     /db_xref="CDD:175979"
     misc_feature    2352..2870
                     /gene="Pik3c2b"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2A_PI3K_class_II; cd04012"
                     /db_xref="CDD:175979"
     misc_feature    2925..3431
                     /gene="Pik3c2b"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; Region: PI3Ka_II;
                     cd00869"
                     /db_xref="CDD:238441"
     misc_feature    2925..3431
                     /gene="Pik3c2b"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; Region: PI3Ka_II;
                     cd00869"
                     /db_xref="CDD:238441"
     misc_feature    3447..4508
                     /gene="Pik3c2b"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase beta; Region: PI3Kc_C2_beta; cd00895"
                     /db_xref="CDD:119421"
     misc_feature    3447..4508
                     /gene="Pik3c2b"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase beta; Region: PI3Kc_C2_beta; cd00895"
                     /db_xref="CDD:119421"
     misc_feature    order(3657..3659,3663..3671,3675..3677,3729..3731,
                     3735..3737,3744..3746,3837..3839,3873..3884,3897..3899,
                     3906..3908,4086..4088,4092..4094,4122..4127)
                     /gene="Pik3c2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119421"
     misc_feature    order(3657..3659,3663..3671,3675..3677,3729..3731,
                     3735..3737,3744..3746,3837..3839,3873..3884,3897..3899,
                     3906..3908,4086..4088,4092..4094,4122..4127)
                     /gene="Pik3c2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119421"
     misc_feature    4062..4088
                     /gene="Pik3c2b"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119421"
     misc_feature    4062..4088
                     /gene="Pik3c2b"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119421"
     misc_feature    4125..4199
                     /gene="Pik3c2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119421"
     misc_feature    4125..4199
                     /gene="Pik3c2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119421"
     misc_feature    4593..4919
                     /gene="Pik3c2b"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Beta Isoform of Class II Phosphoinositide
                     3-Kinases; Region: PX_PI3K_C2_beta; cd07290"
                     /db_xref="CDD:132823"
     misc_feature    4593..4919
                     /gene="Pik3c2b"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Beta Isoform of Class II Phosphoinositide
                     3-Kinases; Region: PX_PI3K_C2_beta; cd07290"
                     /db_xref="CDD:132823"
     misc_feature    order(4701..4709,4779..4784,4824..4826)
                     /gene="Pik3c2b"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132823"
     misc_feature    order(4701..4709,4779..4784,4824..4826)
                     /gene="Pik3c2b"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132823"
     misc_feature    5001..5369
                     /gene="Pik3c2b"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2B_PI3K_class_II; cd08381"
                     /db_xref="CDD:176027"
     misc_feature    5001..5369
                     /gene="Pik3c2b"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2B_PI3K_class_II; cd08381"
                     /db_xref="CDD:176027"
     misc_feature    5151..5183
                     /gene="Pik3c2b"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     misc_feature    5151..5183
                     /gene="Pik3c2b"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     exon            1458..1558
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1713
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1834
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1946
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2026
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2090
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2237
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2431
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2554
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2722
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2834
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2977
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3166
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3260
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3355
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3536
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3644
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3737
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3867
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4004
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4174
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4331
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4441
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4643
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4768
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4886
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..4968
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5075
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5204
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..7918
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgcccc gccctctggc tcccgcgacc aggcgattcg gtgttgcggc tgctgccggc
       61 ggcctgggcc gcggtcctgg caggagccgg tgagcctcgc gcgccgtgca gtgcgctggc
      121 tgtccgggag atggcttctc cccgctcgcc cgccgctcgc gctattgtct cacccggggc
      181 tgcctgactg cgagctcgtg cacgctttca gcagacagca ccgggccccg gaccgtcccc
      241 cacgcccgtt gcttgcccgt gtggtcccct gcagcgggga tcccagagcc gcggtgcggg
      301 cgaagggagc aggcgacact gaacatcacg cgggggctgg agccgggagc ctccgagcga
      361 ggcgggtcgg cggagcacta gacacccagc cacgacagtc agggtgtcgc ggcagaaccc
      421 gcgaccagcg caggtcccga gacaacatgt acctgctgcc ctccatgccg gacgctggca
      481 ggaagtagaa ggcttcgtcg tcgtctcctg tgcccctcgc cctcatcatg tcttcgactc
      541 agggcaatgg ggagcactgg aaatccctgg agtcggtggg catcagccgc aaagagctgg
      601 ctatggctga agccctgcag atggagtatg atgctctttc ccggctccga catcacaagg
      661 aggagagcag ggccaagcaa aacacagagc cctctcttat cagctgggat gagccagcct
      721 tggacttcta cagcaagcca gcaggcaggc ggacagagct caagctcttg cgtggtcttt
      781 ctggctctga tcccacccta aattacaact ccatttcccc accagaagag ctccccaact
      841 ctacctccca ggacccacag cctggcacag atccctggcc caagggctcc caatctggag
      901 actatctcta tatttttgat ggctcagatg ggagatgctc tctgtctcca gtatcaggtg
      961 acaccgatgg ctcttgtaag aaactatccc cacctcctct ccctcctcgg gtctctatct
     1021 gggatgcccc tcccttgcct cctaggaagg gatctccctc accctccaag atctctcagc
     1081 ctgatgacat caacagtttc tctttggtgg aacagccatc tgacaaactg ctaggggccc
     1141 aggacccagg agagggagag ctacccaatg gtgggggaca gcgacatgtg ctggggtccg
     1201 tggactatga cggcatcaat gatgcaatca cgaggctcaa cttgaagtcc acttacgatt
     1261 cggagatatt gtctgacgct accaggggct ggaaggaggg ccgaggaccc ctggacttta
     1321 gcaaggacac ctctgggaaa cctgtagccc ggagcaagac gatgccccct caagtgcccc
     1381 ctcgaaccta tacgccccga tacgccaacc gaaaaaacgc aacacctggc aagaaccgcc
     1441 ggatatctgc cgctccggtg agctctcgga cccacactgt caccaatggc catgaattgt
     1501 ttgaggtctc agaggagaga gatgaggaag ttgctgcgtt ctgccacatg ctagatatcc
     1561 tgcgcacggg ctctgatacc caggactatt ccctaactgg gtgtgtctgg agcactgtca
     1621 ccccgagccc agagcacctt ggggatgagg tcaacctgaa ggtgactgtg ttgtgtgaca
     1681 gtcttcggga gccactcacc tttacctgca actgttcctc caccgtggac ttgctcattt
     1741 accagaccct ctgctacacc cacgacgagc tgagggaggt ggatgtgggc gactttgtgc
     1801 tcaagccctg tgggctggag gaattcctgc aaaataagca cgccttggga agccatgagt
     1861 atatccaaca ctgccgcaag tttgacatca acatccgact acagctgatg gagcagaagg
     1921 ctatccggag cgacctggcc cggacggtga atgatgacca gagcccttcc accttgaact
     1981 acctcatcca tcttcaagag cggccagtca agcagaccat cagcaggcag gccttgagtc
     2041 ttctgtttga cacttaccac aatgaggtgg atgccttcct actggctgaa ggggatttcc
     2101 cactgaaggc tgacagggtg gtccagtctg tgaaggccat ctgcaatgct ctggctgctg
     2161 tggagactcc tgagatcacg agtgctctca accagctgcc tccctgcccg tcacgaatgc
     2221 agccgaaaat ccagaagaag gtggtagaag ccttgacagc agccatcttg gacttagtgg
     2281 agctgtactg cagcacattc aatgcagact tccagacagc cgtacctggg agccgaaagc
     2341 atgatttggt tcaagaggcc tgccacttct ctggggccct ggccttcact gtctatggca
     2401 ctcaccgtat tcccatcatc tgggctacca gctatgaaga gttctacctc tcctgctccc
     2461 tcagccacgg tggcaaggaa ctttgcagcc ctctgcagac ccggcgggct cacttctcca
     2521 agtacctgtt ccacctcatc atctgggacc agcagatctg ctttcccgtg caggtgaaca
     2581 ggctgcctcg ggagaccctg ctgtgtgcca cactctatgc cctgcccatt ccccctcccg
     2641 ggagttcctc cgaagccaat aagcagaagc gggtgcctga agctctgggt tgggtcacta
     2701 cccccctctt caacttcagg caagtcttga cctgtggccg aaagcttctg ggcttgtggc
     2761 cagcaacaca ggagaactcc agtgcccgtt ggagtgcacc aaatttccac cagccagaca
     2821 gtgtcatcct gcagattgac ttccccacct cggcctttga catcaagttc accagccccc
     2881 ctggagacaa gttcagcccc cgctatgagt ttggcagtct ccgggaggag gaccagcgca
     2941 aacttaaaga cattacgcag aaggagtccc tttactggct ctctgatgcc gacaagaagc
     3001 aactgtggga gaagcgctat tactgccaca ctgaggtgag ctcgctcccc ttggtgctcg
     3061 ccagtgcacc cagctgggag tgggcttgcc tgccggacat ctatgctctc ctgcaacagt
     3121 ggactcacat gaaccaccag gatgccctgg gactcctgca tgccaccttc ccggaccagg
     3181 aggtgcggcg catggccgtg cagtggatcg gctccctctc ggatgctgag ctgttggact
     3241 acctgcccca gctagtacag gccctgaagt acgagtgcta cctggatagc cccttggtgc
     3301 gctttctcct gaagcgagcc atctccgacc tgcgagtgac ccactacttt ttctggttac
     3361 tgaaggacag cctcaaggac tcccagttca gcatccgtta ccaatacctg ctagcggccc
     3421 tgctgtgctg ctgtggcaag ggactgaggg aggagtttaa ccgccagtgc tggcttgtca
     3481 ataccctggc caaactggcc cagcaggtcc gagaggccac cccatctgca cgccagggca
     3541 tccttcgtgc gggcttggag gaggtgaggc agttctttgc tctcaatggt tcgtgccgtc
     3601 tgccgcttag ccccagtctg ctggtgaaag gcattgtgcc cagggactgt tcctatttca
     3661 actccaatgc tgtccccctc aagcttgcct tccaaaatgt ggatccactg ggcgagaata
     3721 tcagagtcat cttcaagtgt ggagatgacc ttcgccagga catgctcacc ctgcagatga
     3781 ttcgcatcat gagcaagatc tgggtgcagg aggggctgga tatgcgcatg gtcattttcc
     3841 gctgcttctc cactggccga ggaaaaggga tggtggagat gatacccaat gccgagacac
     3901 tgcgtaagat ccaggtggag catggggtga ccggctcctt caaggaccgt cccctggctg
     3961 actggcttca gaagcacaac cctggggagg atgaatatga aaaggctgtg gagaacttca
     4021 tctactcttg tgccggctgc tgtgtggcta catacatctt gggcatctgt gacagacaca
     4081 atgacaacat catgctgaag accacgggcc acatgttcca tatagacttc ggccgcttcc
     4141 tgggccacgc gcagatgttc ggtaatatca agagggaccg cgccccgttt gtcttcacct
     4201 cagacatggc gtatgtcatc aacgggggtg acaagccttc cagccgcttc catgattttg
     4261 ttgacctttg ctgccaagcc tacaacctca ttcgcaagca cacccatctc ttcctcaacc
     4321 tcctgggcct gatgttgtcc tgtgggatcc ccgagctctc agacctggag gacctcaagt
     4381 atgtgtatga tgccctgaga cctcaggaca cggaggccaa tgccactacc tacttcacaa
     4441 ggttgattga gtccagcttg ggcagcgtag ctacgaaact caactttttc atccacaacc
     4501 tggctcagat gaagttcaca ggctcagacg accggctcac cctctccttt gccccccgaa
     4561 cacatactct caagagctct ggccgcatcc gtgatgtctt tctctgccga catgagaagg
     4621 tcttccaccc tagcaagggc tatatctatg tggtgaaggt gatgcgagag aacgctcacg
     4681 aggcaaccta catccagagg acgttcgagg agttccagga actgcacaat aagctgcgcc
     4741 tgctcttccc ttcctccttc ctgcccagct tccctagtcg gtttgtgatt ggccgctccc
     4801 ggggagaggc agtggctgag aggcggaagg aggagctaaa tggctacatc tggcacttga
     4861 ttcatgcagc ccctgaagtg gctgagtgtg acctggtata tactttcttc catcctctgc
     4921 cccgcgatga gaagacttca ggccctagcc cagccccgaa gtcatcagat gggacgtggg
     4981 cccggccggt tgggaaggtc ggtggggagg tgaagctgtc catttcctac aaaaacaaca
     5041 aactcttcat catggtgatg catattcggg gcttgcaacc gctccaggat ggcagtgacc
     5101 ctgacccata tgtaaagatt tacctccttc ctgaccctca gaaagccaca aagaggaaaa
     5161 ccaaagtagc ccggaaaacc tgcaacccta cctacaatga gatgttggtg tatgatggga
     5221 ttcccaaggg agacctacaa cagcgggagc tccagttgag tgtgctaagt gagcaaggat
     5281 tttgggagaa cgtgcttctc ggggaggtgc acatccgcct tcgggagctg gacctggccc
     5341 aggagaagac cggctggttt gcactgggat ctcgaggtca tggaacctta tgaacccact
     5401 tatggcccag acctgtggca gctgcccaga gctgggggag aagcctctcc ctcacctaac
     5461 tcctttgcta ggaaggggca gagctctcgg tggccttccc cacggtccaa gtggacctga
     5521 cctgggtgtt ggggctggaa gagtcaagtg ctgtccgctg ccccttcccc ccgcagacgg
     5581 caccggggtt ggctgtgacg aacagcccct tggaagctgt gggcttgcag ccgagtttta
     5641 tgtttacctt gtgtcaaggg agcaatgcct gctctggggt gtgtggagtg cgggcaatat
     5701 gaagtagcac ttagagaggg agggtgggtg gatattttat ttttattttt aaaaaatgaa
     5761 atagtaatgt tgtcctaact gggacaggaa gctttgtgtg agaggagcat gctgtgcctc
     5821 agaaggcaaa agagaaagac tgattttttt tttttttttt tttttttttt gtatgatgaa
     5881 agttcttatt ggactttttc tccagggttt tgggggtttt cttttctagc tataggaaat
     5941 attggggagg gccctggtgg gtcctcggtg aagccctccc tctctcaggc agactgggga
     6001 ggagtaggga ggactaaccg actgccggac tgacgctcac tctgggccat ccgattttgc
     6061 ctccaaagga gtgcatcgtg ataactacgt gtgtaaggaa gggccttcca tagtagggtt
     6121 ccgccaagga cctatattca gggacccatg ctctttaggg caaaggattt cctcctctct
     6181 tcccctgctg cttggactct gtgcgagcac cttcctttcc ccttccccac tctgttctct
     6241 cagccctctg tgggtcaccc agtcctggtg actacactgg ggtgcttcta tgccccatct
     6301 tgttcgatgg gacaaaatgc tgccaaccct tagctcgggg ccatgcctat agaggcaccg
     6361 tgccatttgc tgcagtttct gggaactgtc ccccgagacg gtctactact ttctcttcca
     6421 aaccctgttt ctgtcacact ttaaaaagaa cttcattggt tctttttttt ttttttgagc
     6481 tggggaccga acccagggcc ttgcgcttcc taggcaagcg ctctaccact gagctaaatc
     6541 cccaaaccca agaacttcat tctttagggc catgaagctg ttgagggtgt agacaaagag
     6601 gtgctcagtc catagctgca aagagtgagc attggtcaat gcaatcattt cttctggtta
     6661 gtttcctggc cagaaggaag ctggattaga gcatcttcct ctttggaaaa caagcaaaag
     6721 attatttcaa ccccttcctt ccttccttcc ttccttcctt ccttccttcc ttccttcctt
     6781 tttttttttt tctttttcaa gacagggttt ttctgtggag ccctggctgc cttggaacag
     6841 gcagagatcc aactgcctct gcctcccaag tgctgagatt aaaggcgttt gcagccacca
     6901 cctcctggct cacacagctt tcttacgagc tactaggggc caaacccagg gccctttgag
     6961 tactgcacca ccaagctgtg tctccagccc accttgcagt ctttgtttct caccagatga
     7021 atttaaaatc cactctcgag tttccaaaga gttgtctcat tttaaaggtg acaggtagga
     7081 ctcaatttaa ctttttgtat tttttaagac agggtctcac tatgtaccat aggctggcct
     7141 tgaactcaca gagatctgtc tgcctctgcc tctgcacggg aactaacttt taaaagaaga
     7201 gttagcaagg acacgacagt ttctctgtga ccccattact ggagagagaa aaagttccat
     7261 ggaagcttac atggaaacaa gaaacttttt ttgttttgct gttgtttatt ttgcttgttt
     7321 ttgtttatga gaggggatat catgtagccc aggttggctt caaactccta tgtagatgag
     7381 gatgaccctg agctcctgat ctacttgcct ttccaactcg caggtgctaa gattacaggc
     7441 atgagctgcc ccttccattt ttttcttaat ttaaaatggc gggcctgtga ggtggctcag
     7501 tgagtaaggg gacttgctct gtcaacttaa gtttgatcac tgagaccttc gagatggcgg
     7561 gagacgacca actcctacaa gttgttttct gtcctctgta tgcactacac aacatgtgtg
     7621 cacatacaca cacacacaca cacacacaca cacacacaca cacacacaca cacagataac
     7681 ataattttaa aatgccaaga ataaagcagc ctgctgaagg caggagacca gagcagaacc
     7741 ttccagatat ttggaccata gacgagcttc tggctttttg cctgcagctc attttatttt
     7801 gaccctttat gtccccgact taaagaggtc tgtgtactgt acccacttcc catgctcctt
     7861 tatcttctac tttctctgga attgtatttt ttaaataaac gacatttgag aaaacaaa
//
LOCUS       NM_001437071            6889 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            9, mRNA.
ACCESSION   NM_001437071 XM_039097173
VERSION     NM_001437071.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6889)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 6889)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 6889)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 6889)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 6889)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 6889)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 6889)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 6889)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 6889)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 6889)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097173.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2160421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000018.1  65391441-65391665
            226-287             JAXUCZ010000018.1  65391770-65391831
            288-417             JAXUCZ010000018.1  65437939-65438068
            418-467             JAXUCZ010000018.1  65438528-65438577
            468-573             JAXUCZ010000018.1  65507173-65507278
            574-704             JAXUCZ010000018.1  65511025-65511155
            705-837             JAXUCZ010000018.1  65516916-65517048
            838-905             JAXUCZ010000018.1  65525175-65525242
            906-984             JAXUCZ010000018.1  65526319-65526397
            985-1061            JAXUCZ010000018.1  65528841-65528917
            1062-1265           JAXUCZ010000018.1  65531547-65531750
            1266-1401           JAXUCZ010000018.1  65551334-65551469
            1402-1564           JAXUCZ010000018.1  65553405-65553567
            1565-1794           JAXUCZ010000018.1  65556812-65557041
            1795-1935           JAXUCZ010000018.1  65557878-65558018
            1936-6889           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..6889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6889
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..225
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1931
                     /gene="Tcf4"
                     /note="isoform 9 is encoded by transcript variant 9;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 9"
                     /protein_id="NP_001424000.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MKDIFFQFLVARVRKRHSLSCLHTLPVVSPLRKTERGSYSSYGR
                     ENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKV
                     RKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSS
                     GMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNH
                     YSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTP
                     VGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVG
                     PSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGS
                     HSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDEN
                     LQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLR
                     VRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLK
                     RREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    324..>809
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    324..>809
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1599..1853
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1599..1853
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1623..1625,1635..1637,1641..1649,1653..1655,
                     1668..1670,1731..1736)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1623..1625,1635..1637,1641..1649,1653..1655,
                     1668..1670,1731..1736)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1662..1667,1674..1679,1683..1688,1695..1697,
                     1707..1709,1737..1739,1746..1748,1758..1760,1767..1769,
                     1776..1793)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1662..1667,1674..1679,1683..1688,1695..1697,
                     1707..1709,1737..1739,1746..1748,1758..1760,1767..1769,
                     1776..1793)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            226..287
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..417
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..467
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..573
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..704
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            705..837
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..905
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..984
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1061
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1265
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1401
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1564
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1794
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1935
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..6889
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaatggttc aaatttggtg agagaggaag aacgtgaaaa aaaaaggaat gacaatttgt
       61 ttgttagaga aagtggaggc cactggaatg acagtttttg gaagtgtgga gcagtttggc
      121 taagaatagg aatgaaagat atttttttcc agttccttgt cgccagagtg aggaagcgcc
      181 attccctgtc ttgcttgcat acattgccag ttgtgtctcc tctacgtaaa acagaaaggg
      241 gttcatactc atcttatggg agagaaaacg tacagggttg ccaccagcag agtctcctcg
      301 gaggggacat ggatatgggc aacccaggaa ccctttcgcc caccaaacct ggctcccagt
      361 actacccata ttccagcaat aacgcccgac ggaggcctct tcacagtagt accatggagg
      421 tgcagacaaa gaaagtcaga aaagttcctc caggcttgcc atcttcagtc tacgctcctt
      481 cagccagcac tgccgactac aacagggact caccaggcta ttcttcctcc aagccagcag
      541 ccagcacttt ctccagctcc ttcttcatgc aagatggcca tcacagcagt gacccttgga
      601 gctcctccag tggaatgaat cagcccggct atggagggat gctaggcaac tctcatatcc
      661 cacagtctag cagctactgt agcctgcatc cacatgaacg tctgagctat ccatcgcact
      721 cctcggcaga catcaactcc agtcttcctc cgatgtccac gttccatcga agtggcacaa
      781 accattacag cacctcttcc tgcacacctc ctgccaacgg aacagacagt ataatggcaa
      841 acagaggaac tggggcagca ggcagctccc agactggaga cgctctgggg aaagccctgg
      901 cttcgatcta ttctcctgat cacacgaaca acagcttctc ctccaaccct tcaactcctg
      961 ttggctcccc tccttcactc tcagcaggca cagctgtttg gtctcgaaac ggaggacagg
     1021 cctcgtcatc tcccaattac gaaggaccct tgcactcctt gcagagccga attgaagacc
     1081 gtttagaaag actggacgac gcgattcatg ttctccggaa ccacgcggtg ggcccatcca
     1141 cagctgtgcc cggtggccat ggggacatgc atgggatcat cggaccctct cacaatggag
     1201 caatgggcag tctgggctca ggatatggaa ctggccttct ctcagccaac agacattcac
     1261 tcatggtcgg ggcccaccgt gaagatggcg tggcactgag aggcagccat tctctcctgc
     1321 caaaccaggt tccggttcca cagcttccag tccagtctgc aacttcccct gacttgaacc
     1381 caccccaaga cccttacaga gggatgccac caggcctcca gggacagagt gtgtcttccg
     1441 gcagctctga gatcaagtcc gacgacgagg gcgatgagaa cctacaggac acaaaatctt
     1501 ccgaggacaa gaaactagac gacgacaaga aggatatcaa atcaattact aggtcaagat
     1561 ctagcaataa cgatgatgag gacctgaccc cggagcagaa ggccgagcgt gagaaggagc
     1621 ggaggatggc caataacgcc cgtgagcgcc tgagggtccg tgatatcaac gaggctttca
     1681 aggagctggg ccgcatggta cagctccacc tgaagagcga caagccccag accaagctcc
     1741 tgattctcca ccaggcagtg gctgtcatcc tcagcctgga gcagcaagtg cgagaaagga
     1801 acctgaaccc aaaagctgcc tgtctgaaaa gaagggagga agagaaggtg tcctcagagc
     1861 ctcccccgct ctccttggct ggcccacacc ctgggatggg agacgcagcg aatcacatgg
     1921 gtcagatgtg aaagggtcca agttgccacc ttgcttcatt aaaacaagag accacttcct
     1981 taacagctgt attatcctaa acccacataa acactgctcc ttaaccccgt tttttttgta
     2041 atataagaca agtctgagta gttatgaatc gcagacgcaa gaggtttcag cattcccaat
     2101 tatcaaaaaa cagaaaaaca aacacaaaaa aaaaatgaat gaaagaaaga aagaaagaga
     2161 aaatgcaact tgagggacga cttctttaac atatcactct gaatgtgcga agcggtatgt
     2221 acaggctgag acgcagccca gagactgaat ggcaatcctt ccacactgtg gagcaatgca
     2281 tttgtgccta aacttctttt ggaaaaaaaa atataattaa tttgtaagtc tgaaaaaaaa
     2341 tatttaattt aaaaaaaatt gtaaacttgc aataatgaaa aagtgtactt ctgaagaaaa
     2401 acgacatgaa cgtttttgtt ggtattcaag tcagctagtg tttctaatta ccggatattg
     2461 aatagaggaa gcccggctac cctcataaca aaaccagcaa ccgtcctgat ggcaaccgaa
     2521 atgatgacat tagccattcc ttagggtagg agggacagat ggatgttata gacctatgac
     2581 aaatatatat ataaatatat atataaatat atattaaaaa tttagtgact atggtaagct
     2641 tttgttcatt tgtttcagac ttttttctcc tgtaaaaaaa tagtactgat taactttttt
     2701 aaaagaaaga ttttactgta aatatggatt tttttttgtc tgatttttgt cccttccccc
     2761 agtttgttat cgtgacctgt agtgccaact ctgcttccgg aggggcagtg caggacgaaa
     2821 tgctgaccct gatgttgctt ctcattcata aatagtagaa agttgtttct ccagtctttt
     2881 gggaacacag gacttaaaag tcacatcatg tgtagaaatt acatgcagca ttgcccgggc
     2941 aaggcaaaaa gagtttgtct ggcttgtggc actgtgcttg ttaccctctc ctgggatttt
     3001 cagaggtaca cggttagaat gctacaatgt taccactgtg ccttccaatg tttatatcat
     3061 cggaaacatg acataatcaa agtggctgtg atttaacaaa aaaaaaaaaa gattcaagtg
     3121 ttacctacct gtgtagcgga agtagtgtgc agtgagacgt ttctgaatac atggtcagat
     3181 tttttttgga aaaaatacaa aaacaaaaaa aaaaaacaaa aaaatttaaa aaaaaaagtc
     3241 aagttcaaaa accgtcaaat gagaaaatcg caaggagtgt gacagctgat tgattttgtt
     3301 gcttttcttg attttttttt ttttgtttcc aaatgggttt actaaaaagt acatgactta
     3361 cctgcctcct ccttcgtctg aaaacaaaaa acaaaaaaac aatgccaacc tatcccacag
     3421 cattatagca agccttataa gccctaaagc attaagttgc actttggtga ggaggggtag
     3481 cgcagtattc tctctggcca gtatgagtga agtttatact taacatttga tagaaacata
     3541 gatcaaactg tggcacagta actcatcaga tagctagcgt tgactctggg cacaattgaa
     3601 ccaattccca tcctaaatct ttccaacaat tgactttggt gtacagtgca gtgaacacat
     3661 agaactccta cttaagtatt cgtcagcatc cttttgtctc taactcggtt ctgttttgac
     3721 agccacacaa tcttggcatg tattaagtaa aaaaaaaaaa aaaatccctg ttgaagtagt
     3781 tttcccacct atcagcactg agtaattgcc gtaactcaat ggaaatggtc taaacgcccc
     3841 ccatctcttg tcctgtacca ccagttacac agtgacaaaa cacatctgta aattttatgc
     3901 aaccaatggc aaacctatca ttattttgaa actgtgtatg taaaagttat atttttacat
     3961 gtagactctt gttattatgt gttttaatac attgtatcag ttttttgttt cctttttttt
     4021 ttaactgtgt ggttttaaaa agtcatttaa atgaaatagc gagctacaag aatctgaaat
     4081 ttatgttcat ttctgaaaat gtaagaacaa ataagatagt tatcacgtgg tcacctttta
     4141 caaacccatc gatgttttga ctagctgtgt gtatgtgtgt gtgtgcgcat gtgtgcgtgt
     4201 gtgtgtatgt gtgttgaaaa ctgtaaatat gttcagtagc gataaaacga caatgctttg
     4261 atttgttgag aagttcctaa aatgtggagg tggattgaaa atgtagggga atagcagaaa
     4321 tcagatttca tgaagagctc ttctcttcgg gggctttcct gtggaatggt caaacagagg
     4381 tgctccaaga agggcaagga agacagtaac ttcccctcct ccctgaacga cggaaaccat
     4441 gtgtacgtgg tctctcacca tgttaaagat tttctttccg tgatacattc tgcactcttt
     4501 ttgtatagtc taccaaggcg ggtatccctg ggaacaatat tatgatatag gaagcagtat
     4561 actctgatca cattcaggag aattgtatag aagagaatat ggtgtttact ctttagggaa
     4621 ctggaaattc tccctgcatt gatgtacatc ttcagagcgg cccttttgat acacgttatc
     4681 ataaaggtgc tgactaaagc agaattaaag tttttcaaat ctgtaaacaa agcaaaaaat
     4741 taaattacag tcattcgatt gtttgttttt ttttttttcc aattggtgct tttatatttt
     4801 gttctcactc agacagaaaa ggctgcaatt tcttgttcac cagctttgat gtattcatta
     4861 ctcggtaatg taatacggct attgtcaaat tccttttgga aataagcaaa aggcttcccc
     4921 aaggcctgca gcagctgctg gctactttct gcttggcgca gaaacatgat ctgaccctct
     4981 ctgtagtaat cgagttgtat ctccagtttt aaaaagaagg aaaaagggaa tgtggccgtt
     5041 ttaatgtgtt tttttttttc ttttcttgtt gttattttgt aattctcaaa cccaggtaag
     5101 atattggtat tcctgcactg gatttttgaa agaaacttag cagaagacag gatcgagata
     5161 ctatagaagc atttcccaag tgttcatact atactagaca taaatgataa cggcgatgta
     5221 taggttcagg atcggtttaa gagactcaga ctttgaaagc aacttggaac ggttgatcca
     5281 cctccacatt cgagtaatta ataattctgc agaattaggg atctgtccat ctaggagttg
     5341 ttacccattt gtcttctgtg tggctgcgag gaacactaac gcttttacaa ctgtcagttc
     5401 acccagtggt acaactgatt ctgactcagt cttccgattc ctgttttgta ttttgttttt
     5461 ccactttttt cctatctctt gattttattg ttgttgttat tgctattgtt attattatta
     5521 ttcgtgatct ttatttcgat gaggggttgg gaagtgggag ggagtcgaac tgagactagg
     5581 ggttgagagg atttttttgg tttggttttc ttttcttttt tttttgtttt tttttttttt
     5641 tgtttgtttg tttcatcttt gcgtccaaca ggcagaatat ggtctgtgtc caaaacggaa
     5701 cttaagtcag gaaggaaacc attcagcgta aacaagcaca acatgtagtc tgtcggctgt
     5761 ctggaagcaa aaataaatta ataaataaat aataaataag taaaagacac acacggaggt
     5821 gaagatgaaa tgtgatggat tccgagacaa tggggcacca aggcctgtag gcctcctctt
     5881 gattttgctt tggttatgtt tgttttcctt agagatgttt ttttcctcac gggacttgaa
     5941 gtgactcatc tctgtgcagt aatggtttcg ccatatgctc atttcaagta ttatagacat
     6001 atgtaatggt gaaatatatg aactgtggcc tttttcattc ttgttatttg tgatgcaatt
     6061 aagtgaagag aagaaaaaaa aaagcagaga tttaccatgt atcagtgcct ggctttttgt
     6121 tataaagctt cgtctgtcta gtgctctttt tgctataaaa atagactgta gtacacccta
     6181 gtaggaaaaa aaaaccctaa atttaaaaat aaaaaaatat atttggctta tttttcgcag
     6241 gagcaatcct tttataccat ggatattaca aaaaaaaaaa ttgtcagatt ctgaatattt
     6301 cttctttgta gatttttgga atcattataa gtaaaagttt gttactttat tttactattt
     6361 aaaagatgtt attttgccat gtgttactga gatgaaactg tatggtatag cttcttctgt
     6421 tcgttttttg tttccggttt tttgtttgtt cgtttttggt tttttttttt tttgtttgtt
     6481 tgttttgttt tgtttttttt tcttagttgt aggtcgcagt aaggactttt ccttttgttt
     6541 ttgttttttc gttatgtttt gttttgtttt tgcgactgta cacatagctg cagcattaaa
     6601 aacttttaaa aaaatctgtt aaaaaaaaaa gaaaaaaaag ggaaaacgtt taaaaaaaaa
     6661 agataaacag ttacaccttg ttttcaacgt gtggctgagt gcctcgattt tttcatgttt
     6721 ttggtgtatt tctgatttgt agaagtgtcc aaacaggttg tgtcctggac ttccttcaag
     6781 aggcgaacaa cccagcttgg tctaggccat gacctgttcc catctgtagt tactcgatga
     6841 agtcatgtac atgaccgttc tgtagcaata aatgtgccat ttttataaa
//
LOCUS       NM_001437086            5042 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 11, mRNA.
ACCESSION   NM_001437086 XM_063288040
VERSION     NM_001437086.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5042)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5042)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5042)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5042)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5042)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5042)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5042)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5042)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5042)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5042)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_063288040.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3025406.1,
                                           SRR26360194.1825152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-712             JAXUCZ010000005.1  148181206-148181372
            713-983             JAXUCZ010000005.1  148183570-148183840
            984-1077            JAXUCZ010000005.1  148195258-148195351
            1078-1194           JAXUCZ010000005.1  148197665-148197781
            1195-1346           JAXUCZ010000005.1  148200975-148201126
            1347-1485           JAXUCZ010000005.1  148203568-148203706
            1486-1629           JAXUCZ010000005.1  148205552-148205695
            1630-1926           JAXUCZ010000005.1  148206678-148206974
            1927-2163           JAXUCZ010000005.1  148208059-148208295
            2164-2431           JAXUCZ010000005.1  148218465-148218732
            2432-2561           JAXUCZ010000005.1  148219783-148219912
            2562-2690           JAXUCZ010000005.1  148221617-148221745
            2691-2828           JAXUCZ010000005.1  148225153-148225290
            2829-2954           JAXUCZ010000005.1  148228732-148228857
            2955-3076           JAXUCZ010000005.1  148229514-148229635
            3077-3269           JAXUCZ010000005.1  148231206-148231398
            3270-5042           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5042
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3401
                     /gene="Pum1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 11"
                     /protein_id="NP_001424015.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEGPRDADSDENDKGEKK
                     NKGAFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGP
                     NQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSA
                     AATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGMFPAGLAPAAFV
                     PNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAA
                     ATNSATQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQ
                     GLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVA
                     AAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQS
                     SSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSD
                     LYKRTSSSLAPIGHSFYNSLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLN
                     LGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSR
                     LLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAA
                     YQLMVDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPS
                     DQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPY
                     GCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVA
                     EIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYA
                     NYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPIC
                     GPPNGII"
     misc_feature    2367..3332
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2367..3332
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2535..2540,2547..2549,2643..2648,2655..2657,
                     2754..2756,2763..2765,2859..2864,2871..2873,2958..2963,
                     2967..2972,2979..2981,3066..3071,3075..3080,3087..3089,
                     3195..3200,3204..3209,3216..3218,3306..3308,3315..3317)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2535..2540,2547..2549,2643..2648,2655..2657,
                     2754..2756,2763..2765,2859..2864,2871..2873,2958..2963,
                     2967..2972,2979..2981,3066..3071,3075..3080,3087..3089,
                     3195..3200,3204..3209,3216..3218,3306..3308,3315..3317)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..712
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..983
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1077
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1194
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1346
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1485
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1629
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1926
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2163
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2431
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2561
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2690
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2828
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2954
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3076
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3269
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..5042
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagggccc aagggatgca gacagtgatg aaaacgacaa aggtgaaaag aagaacaagg
      601 gtgcgtttga tggagataag ctaggagatt tgaaggagga gggagatgtg atggacaaga
      661 ccaatggttt gccagtgcag aatgggattg atgcagacgt caaagatttt agccgtaccc
      721 ctggtaattg ccagagctct gctaatgaag tggatcttct gggtccaaac cagaatggtt
      781 ctgagggctt agcccagctg accagcacca atggtgccaa gcctgtggag gatttctcca
      841 acatggagtc ccagagtgtc cccttggacc ccatggaaca tgtgggcatg gagcctctgc
      901 agtttgatta ttcaggcacg caggtacctg tggactcagc agcagcaaca gtgggacttt
      961 ttgactacaa ttctcaacaa cagctattcc aaagacccaa tgcgcttgct gttcagcagt
     1021 tgacagctgc ccagcagcag caatatgcac ttgcagcagc ccaccagcct cacatcggta
     1081 tgtttccagc aggtttagct cccgctgcgt ttgtccccaa cccatacatc atcagcgctg
     1141 ctcccccagg gacggacccc tacacagctg gattggctgc agcagcgaca ctcggcccag
     1201 ctgtggtccc tcaccaatat tatggagtca cgccatgggg tgtctatcct gctagtcttt
     1261 tccagcaaca agctgctgca gctgcagcag caacaaattc agctactcag cagagtgccc
     1321 cacaggccca gcagggacag cagcaggttc ttcgtggagg agctagccag cgtcctttga
     1381 ccccaaatca gaaccagcag ggacaacaaa cagatcccct tgtagcagct gcagcagtga
     1441 actctgctct tgcctttgga caaggattgg ctgcaggtat gccaggttat ccagtcttgg
     1501 cacctgctgc ttactatgac caaactggtg cccttgtggt gaatgcaggg gcaagaaatg
     1561 gcctcggagc tccagttcgg cttgttgctc cagccccagt catcattagc tcctcagctg
     1621 cacaagcagc tgttgcagcg gctgcagctt cagcaaatgg agcagccggt ggtcttgcag
     1681 gaactacaaa tggaccattt cgacctttag gcacccagca gccccagccc cagccccagc
     1741 agcagcccag taacaatctg gcttccagct ctttctatgg caacaactct ctgagcagta
     1801 actcccagag cagctccctc ttctctcagg gctccgccca gcctgccaac acgtccttgg
     1861 gattcggaag cagcagttcc cttggtgcca ccctaggatc ggcccttgga gggtttggaa
     1921 cagcagttgc aaactccaac actggcagtg gctcccgccg tgactccctg actggcagca
     1981 gtgaccttta taagaggaca tcgagcagct tggcccccat tggacacagt ttttataaca
     2041 gccttagctt ttcctcctct cctggacccg tgggcatgcc tctccctagt cagggaccag
     2101 gacattcaca gacaccacct ccttccctct cttcacatgg atcctcttca agcttaaacc
     2161 tgggaggact cacgaacggc agtggaagat acatctctgc tgctcctggt gccgaagcca
     2221 agtaccgcag tgcgagcagt gcctccagcc ttttcagccc cagcagcacc cttttttctt
     2281 cctctcgttt gagatacgga atgtctgatg ttatgccctc tggcaggagc agacttctgg
     2341 aagactttcg aaacaaccgg taccctaatt tacaactgcg ggagattgcc gggcatataa
     2401 tggaattttc ccaagaccag catggttcta gattcattca gctgaaacta gagcgagcca
     2461 cagcagctga gcgccagctt gtcttcaacg aaatcctgca ggctgcgtac caacttatgg
     2521 tggatgtgtt tggaaattac gtcattcaga agttctttga atttggcagc catgaacaga
     2581 agctggcttt ggctgaacgg attcgaggcc acgtcctatc attggcactg cagatgtatg
     2641 gctgccgagt catccagaaa gctttggaat ttattccctc agaccagcag aacgagatgg
     2701 tgcgggagct agatggccat gtcctgaagt gtgtgaaaga ccagaatggc aaccatgtgg
     2761 ttcagaagtg cattgaatgt gtacagcccc agtctttgca gttcatcatc gatgcattca
     2821 aggggcaggt gtttgctttg tctacgcacc catatggctg tagggtgatc cagaggatcc
     2881 tggaacactg tctccccgac cagaccctcc ctatcctgga ggagcttcac cagcacacgg
     2941 agcagctcgt gcaggatcag tatggaaatt atgtaatcca acatgtcctg gagcatggtc
     3001 gtcctgagga taaaagcaaa attgtagcag agatccgagg caatgtactt gtattgagtc
     3061 agcacaaatt cgcaagcaat gttgtggaga agtgtgtcac tcacgcctca cgtacagagc
     3121 gtgctgtgct cattgatgag gtatgcacca tgaatgacgg tccccacagt gccttataca
     3181 ccatgatgaa ggatcagtat gccaattatg tggtccagaa gatgatcgat gtggctgagc
     3241 cggggcagcg gaagattgtc atgcacaaga tccggccaca catcgcgact cttcggaagt
     3301 acacctatgg caagcacatc ctggccaagc ttgagaagta ctacatgaag aatggtgtgg
     3361 acttggggcc catttgtggt ccccctaatg ggatcatctg agcagtgcac ccatccctgt
     3421 cccgctgacc tcactgaccc tggcagatcc aaccagcaac cagagatgcc cagctcagag
     3481 tcgaaagtgg gcgatggttg ctccgggatt gctccctcct ccaaaaatgg aatcggatcc
     3541 acttgtggaa aggcctttgt aaatttcatt ttattacaca taacatgtac taattatttt
     3601 ttttaattga ctaattgccc tgctgtttac tggtgtatag gaacttgtac ataggtaatc
     3661 agtgtacatg agaggccaca tgctttgttc aatgttgtat ctatattcca catgtggaca
     3721 ctttcagggt ggttggttta acaaaaaaag ttttaaaaaa agacaaaaaa aggtttttaa
     3781 ctcatttgcc ttgtggcaag ttttgcaaat agctcttccc caccccattt tattaaaaaa
     3841 agaaacctga gaaatttgaa ttttagttaa ataatctcaa actggcattt aacactgttt
     3901 ataaaatata tatatatata tacatatata catatgaaat gggaacgttt ccgagttgct
     3961 aaagcatcag cctgtgatac ggagtttatg acgctctttg gagatgacct catgctgagg
     4021 gaggtggtag ctgcagatcc aggaggagcg ggaagcacag agacaggccg gaggccagtg
     4081 ggcatggcca cttgctctat gggttgcctt ctgtgaacac tgggaagcag aatctgatta
     4141 tctagcatga gagaacccag ctctgctcct ggtctggctt ctatagatac atagtgtata
     4201 cttgtgtaga ctttgcatat atacggattt gtagtatttt cctgttttga tgtctaatct
     4261 gtatctataa tgtaccctag tagtcggaca tacttttgat tgtacaattg tacatttgta
     4321 tacctgtaat gtaaatgtgg agaagtttga atcaacatga acacgttttt ggtaagaaga
     4381 gaaccggcca gcccgtgcac tctgtatatc ccacctttta tggttgtagc agatagtgtt
     4441 gtatattgta aattgtaatt tcaaacagaa gtaaattttt ttcttttgaa ggaataaatg
     4501 ttctttatac agcctagtta atgtttaaaa agaaaaaata gcttggttta tttgtcagct
     4561 agtcaagacg gtagtgagag cctttctaaa tgttacttca gatgattcag ttcacactag
     4621 tgttcctttt ttttttttta tcctaagaaa aggtaatgtt tcgcttattt tgtgacagtc
     4681 aaaaggatgt gcagaagttt cgcctgcccc ttccctgctc accacctccc cttgtaaagt
     4741 gactcaccct ccgttttgta cagatgagct gtattttgca ttttgtctac ttgtaagtga
     4801 atgtaacata ctgtcaatcc tcgtttgaat atagactgta acactacacg gtgtacattt
     4861 ccagagcctt gtgtatattt ccaatgaact ttttgcaagc acacttgtaa ccatatgtgt
     4921 ataattaaca aacctgtgta tgcttatgcc tgggcaacta ttttttgtaa ctcttgtgta
     4981 gattgtctct aaacaatgtg tgatctttat tttgaaaaaa atacagaact ttggaatctg
     5041 aa
//
LOCUS       NR_199188                708 bp    RNA     linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 18,
            non-coding RNA.
ACCESSION   NR_199188
VERSION     NR_199188.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ240293.1, BP499690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-708              JAXUCZ010000016.1  6893598-6894237
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..708
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     misc_RNA        1..708
                     /gene="Btd"
                     /product="biotinidase, transcript variant 18"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..708
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagaa aatcccatgt taccactatg agaaggattt tctttccaaa gcggtacgtc
      121 cttaagcaag tgattcggag tagcagacaa agcagaaaac agtgaaagcc gtgtgcggga
      181 ctctgacagg gagacttctt tatggctgcc ctgtgggtga cacagcagat gctagaattc
      241 caaaccgccc caaataaaaa ctgaagaata tcggctagga agctgccctg cgttcgggag
      301 cctcaggacc atcgcggctg tcctagaggg ctgacctgca atgctatgta tgtaagaaga
      361 ctcgagcaaa gcatcatcaa atatatcgca gaattgtgtc caaatttcag cccagttcct
      421 gcggcgcagg gtaggtgcct gactagcaag gcagtgacgc actgcaggct tcctgcatgc
      481 cgcgttagaa cactgaggca aacaccgagt ctgttttgga aatgttctga agccagtcta
      541 ttaacacagc gagccgtttg aaacgcagcg ctacgtgttt ggagagaaac acacgggctt
      601 ttattaggga catgaaacaa actctttgag ccccagcatc gctgcgggcg agtgtaattg
      661 ccaggattaa taaatcacag ctgcgaaagg ctgtccttgg caaccttc
//
LOCUS       NR_199189                786 bp    RNA     linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus biotinidase (Btd), transcript variant 19,
            non-coding RNA.
ACCESSION   NR_199189
VERSION     NR_199189.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 786)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 786)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 786)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 786)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1162339.1, CB790115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000016.1  6869515-6869582
            69-146              JAXUCZ010000016.1  6870286-6870363
            147-786             JAXUCZ010000016.1  6893598-6894237
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..786
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     misc_RNA        1..786
                     /gene="Btd"
                     /product="biotinidase, transcript variant 19"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..68
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            69..146
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..786
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcttttcc ggactcggcc atcagcggga ggcgggacga gccggagacc gcgtcctcta
       61 ccgagcagga tcagtcttca actggccaat tttgccattt ggcaaagaga aaaatcactg
      121 ggcaagttac tgccttgcag ttcaagaaaa tcccatgtta ccactatgag aaggattttc
      181 tttccaaagc ggtacgtcct taagcaagtg attcggagta gcagacaaag cagaaaacag
      241 tgaaagccgt gtgcgggact ctgacaggga gacttcttta tggctgccct gtgggtgaca
      301 cagcagatgc tagaattcca aaccgcccca aataaaaact gaagaatatc ggctaggaag
      361 ctgccctgcg ttcgggagcc tcaggaccat cgcggctgtc ctagagggct gacctgcaat
      421 gctatgtatg taagaagact cgagcaaagc atcatcaaat atatcgcaga attgtgtcca
      481 aatttcagcc cagttcctgc ggcgcagggt aggtgcctga ctagcaaggc agtgacgcac
      541 tgcaggcttc ctgcatgccg cgttagaaca ctgaggcaaa caccgagtct gttttggaaa
      601 tgttctgaag ccagtctatt aacacagcga gccgtttgaa acgcagcgct acgtgtttgg
      661 agagaaacac acgggctttt attagggaca tgaaacaaac tctttgagcc ccagcatcgc
      721 tgcgggcgag tgtaattgcc aggattaata aatcacagct gcgaaaggct gtccttggca
      781 accttc
//
LOCUS       NM_001017495            1514 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 4 open reading frame
            36 (C14h4orf36), transcript variant 1, mRNA.
ACCESSION   NM_001017495 XM_573553
VERSION     NM_001017495.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079214.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573553.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079214.1, CK598909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1514
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="similar to human chromosome 4 open reading frame
                     36"
                     /db_xref="GeneID:498330"
                     /db_xref="RGD:1564576"
     exon            1..254
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..389
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    313..315
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="upstream in-frame stop codon"
     CDS             325..678
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="AFF1 antisense RNA 1"
                     /codon_start=1
                     /product="uncharacterized protein C4orf36 homolog"
                     /protein_id="NP_001017495.1"
                     /db_xref="GeneID:498330"
                     /db_xref="RGD:1564576"
                     /translation="MAYGLPRRNTVQNILKGSCYKIQEPWDLAELTKTWYSNLTNINL
                     PFLGEIAFGSPMNLLAGQTKQDCPLPSMQTMALEKEYEAKRLAKLKSKENACKEMQVS
                     LREKSVGLRRPLQPK"
     misc_feature    325..675
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="Protein of unknown function (DUF4522); Region:
                     DUF4522; pfam15022"
                     /db_xref="CDD:434399"
     misc_feature    325..675
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="Protein of unknown function (DUF4522); Region:
                     DUF4522; pfam15022"
                     /db_xref="CDD:434399"
     exon            390..544
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1488
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggtcct ggtgttagca aggggcaact ctagcaaaac cctccggcac agcacagtgc
       61 caccgtttgc ttgggaccct aagagatgga gtccatctgt tcttcacagg aacacggagc
      121 tgtcgtcgga gcctcgagtg tgggcgtggg ccagcgactg tcacccacta gagcaaagtg
      181 actcccatgg agcgggctgg gtttgcgccc tgcgcgtgca taaagccctt tattgaggcg
      241 acaggtgacg cagggcatag tgaatagagc ggcgcagatg ttacatcggg cttctatgta
      301 aggaaacgat tgtgatcatt tgtcatggcg tatggcttgc cgagaaggaa cacagtgcaa
      361 aacattttga agggcagctg ttataaaata caggaaccat gggaccttgc ggagctcaca
      421 aagacctggt attcaaactt gacgaacatc aacttgccgt tcttgggaga aatcgcattt
      481 ggtagcccta tgaatctctt ggcaggccaa accaaacaag actgcccgct cccttcaatg
      541 caaaccatgg cacttgaaaa ggagtacgaa gcaaagcgcc tagcgaagct gaagtctaag
      601 gagaacgcgt gtaaggagat gcaggtttca ctgagggaaa agagtgtcgg cctgagaaga
      661 ccacttcagc ccaagtgacc cgaccacgta gcgtcaaacc tgaacctgtt tccggcatcc
      721 acgggcggcg aagctttcgg attcctccac agtgtcaagt agacacagca ctgtgtctat
      781 gggcgatggg gccaatgttg ctagacctgg ctcggcgaac gctgacagag cccccgggtt
      841 cctgccacac tcctgttctt tgtgccccac acagcagccc tctctgtaag tagatgagaa
      901 cgcatctgga gttgagtcgt tttgtgttcg ctcgtttcaa tgtctgtaag atcgcgtgcg
      961 gaagaggaca gttcttgtga gagtcagcgc tctgaagaga cgtttgcgat cccaaggaga
     1021 cttctcaaaa cgaagtcaga aagaagtcct tttaaaatga gaaaccgcat tttttctttt
     1081 tttctttttt ttctggttaa gaaaaacaga aaaacgatta agatttcctt tctgtcaact
     1141 cttcagttac caatttttgg taaagtttcg tttaatcgtt ctcacgtgcc acttcatgtt
     1201 taaatttttt atcacgtggt actttaaagt aagacttact tggcttttgt tcttctggaa
     1261 aaaaatgttg agccgctttc tttctggcta atattctttc tgcaacggac ctggagcagg
     1321 tgcggcacgt gtgtgtgaaa gggacacaga gggacaaaga cggcctcact gtgaggaaaa
     1381 tttatatttg cagagaggct ggggaatgag caaataaaga gaaagaactg agtttgtatg
     1441 aacaaagttt tctagaattt gaatccaata aagcatattt ggatactaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaa
//
LOCUS       NM_001436894            7822 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus Scm-like with four mbt domains 1 (Sfmbt1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436894 XM_063275680
VERSION     NM_001436894.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7822)
  AUTHORS   Zhang,J., Bonasio,R., Strino,F., Kluger,Y., Holloway,J.K.,
            Modzelewski,A.J., Cohen,P.E. and Reinberg,D.
  TITLE     SFMBT1 functions with LSD1 to regulate expression of canonical
            histone genes and chromatin-related factors
  JOURNAL   Genes Dev 27 (7), 749-766 (2013)
   PUBMED   23592795
REFERENCE   2  (bases 1 to 7822)
  AUTHORS   Lin,S., Shen,H., Li,J.L., Tang,S., Gu,Y., Chen,Z., Hu,C.,
            Rice,J.C., Lu,J. and Wu,L.
  TITLE     Proteomic and functional analyses reveal the role of chromatin
            reader SFMBT1 in regulating epigenetic silencing and the myogenic
            gene program
  JOURNAL   J Biol Chem 288 (9), 6238-6247 (2013)
   PUBMED   23349461
REFERENCE   3  (bases 1 to 7822)
  AUTHORS   Wu,S., Trievel,R.C. and Rice,J.C.
  TITLE     Human SFMBT is a transcriptional repressor protein that selectively
            binds the N-terminal tail of histone H3
  JOURNAL   FEBS Lett 581 (17), 3289-3296 (2007)
   PUBMED   17599839
REFERENCE   4  (bases 1 to 7822)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 7822)
  AUTHORS   Usui,H., Ichikawa,T., Kobayashi,K. and Kumanishi,T.
  TITLE     Cloning of a novel murine gene Sfmbt, Scm-related gene containing
            four mbt domains, structurally belonging to the Polycomb group of
            genes
  JOURNAL   Gene 248 (1-2), 127-135 (2000)
   PUBMED   10806358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063275680.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.51910.1,
                                           SRR26643288.54981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000016.1  5897168-5897415
            249-387             JAXUCZ010000016.1  5958632-5958770
            388-482             JAXUCZ010000016.1  5963348-5963442
            483-723             JAXUCZ010000016.1  5967243-5967483
            724-812             JAXUCZ010000016.1  5972540-5972628
            813-1059            JAXUCZ010000016.1  5974739-5974985
            1060-1148           JAXUCZ010000016.1  5975505-5975593
            1149-1250           JAXUCZ010000016.1  5976527-5976628
            1251-1401           JAXUCZ010000016.1  5978323-5978473
            1402-1484           JAXUCZ010000016.1  5981717-5981799
            1485-1611           JAXUCZ010000016.1  5994334-5994460
            1612-1725           JAXUCZ010000016.1  5995394-5995507
            1726-1768           JAXUCZ010000016.1  5997510-5997552
            1769-1830           JAXUCZ010000016.1  5999669-5999730
            1831-1970           JAXUCZ010000016.1  6000440-6000579
            1971-2080           JAXUCZ010000016.1  6004687-6004796
            2081-2256           JAXUCZ010000016.1  6005740-6005915
            2257-2435           JAXUCZ010000016.1  6008847-6009025
            2436-2681           JAXUCZ010000016.1  6009199-6009444
            2682-2810           JAXUCZ010000016.1  6010622-6010750
            2811-7822           JAXUCZ010000016.1  6011300-6016311
FEATURES             Location/Qualifiers
     source          1..7822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..7822
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Scm-like with four mbt domains 1"
                     /db_xref="GeneID:58967"
                     /db_xref="RGD:61999"
     exon            1..248
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            249..387
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    276..278
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="upstream in-frame stop codon"
     CDS             360..2951
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Scm-related gene containing four mbt domains"
                     /codon_start=1
                     /product="scm-like with four MBT domains protein 1"
                     /protein_id="NP_001423823.1"
                     /db_xref="GeneID:58967"
                     /db_xref="RGD:61999"
                     /translation="MNGEQQLDADLGSGVEVEEFSWEDYLEETGATTAPYASFKHVDI
                     CLQSGFAPGMKLEVALRKDPETYWVATVITACEQLLLLRYEGYGEDRKADFWCDIRRA
                     GLYPIGWCQQNKKTLEAPEGIRDKVSDWSAFLQRTLTGACGPPVALLEGLRNGRNPLD
                     LIAPGSRLECQDFRDSVSTWIVTVVENIGGRLKLQYEGLERHDGFEHWLYYLDPFLHH
                     IGWAAQQGYELQPPLAIRHLKNEADWQEILARVKEEEPLPSYLFKDKQVIRTHEFSIN
                     MKLEAVDPWSPFGISPATIAKVFDDKYFLVEIDDLRPEDHARRSFVCHANSPGIFPVQ
                     WSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSVSEHQFKENMKLEAVN
                     PLFPEEVSIATVTAVRGSYLWLQLEGSKKPVPEFIVSVESMNIFPLGWCETNGHPLST
                     PRRARGHKLRKIAVVQPEKQILSSRTVHEGLKNQLNSPHSVMINGKYCCPKIYFNHRC
                     FSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHG
                     CGEVLKAKYKGKSYRATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENC
                     SVLTKTKYTHYYGKKKNKRIGRPPGGHSNLSCALKKTSKRRKRRKNIFVHKKKRSSAS
                     VDNTPVGSPQGSGGEDEDDADDGDDDSLTEGSTSEQQDELHEESEVSEKKSCSPSPTQ
                     SEMSTPLPPDTQTDKREAQTSSLSDGENKPPSPKEIRIEVDERLHLDSNPLKWSVADV
                     VRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFA
                     FYEQFAN"
     misc_feature    417..719
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 1"
     misc_feature    498..779
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    498..779
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    order(537..539,546..548,555..557,561..563,609..611,
                     618..620,636..638)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    order(537..539,546..548,555..557,561..563,609..611,
                     618..620,636..638)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    741..1055
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 2"
     misc_feature    834..1124
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="second malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt2; cd20113"
                     /db_xref="CDD:439103"
     misc_feature    834..1124
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="second malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt2; cd20113"
                     /db_xref="CDD:439103"
     misc_feature    order(873..875,882..884,891..893,897..899,945..947,
                     954..956,972..974)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439103"
     misc_feature    order(873..875,882..884,891..893,897..899,945..947,
                     954..956,972..974)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439103"
     misc_feature    1083..1397
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 3"
     misc_feature    1170..1451
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="third malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt3; cd20115"
                     /db_xref="CDD:439105"
     misc_feature    1170..1451
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="third malignant brain tumor (MBT) repeat found in
                     Scm-like with four MBT domains protein 1 (SFMBT1); Region:
                     MBT_SFMBT1_rpt3; cd20115"
                     /db_xref="CDD:439105"
     misc_feature    1419..1712
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: MBT 4"
     misc_feature    1497..1766
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    1497..1766
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="malignant brain tumor (MBT) repeat; Region: MBT;
                     cl45897"
                     /db_xref="CDD:459242"
     misc_feature    order(1533..1535,1542..1544,1551..1553,1557..1559,
                     1605..1607,1614..1616,1629..1631)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    order(1533..1535,1542..1544,1551..1553,1557..1559,
                     1605..1607,1614..1616,1629..1631)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative methyllysine peptide binding site
                     [polypeptide binding]; other site"
                     /db_xref="CDD:439080"
     misc_feature    1854..2201
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SLED domain; Region: SLED; pfam12140"
                     /db_xref="CDD:463469"
     misc_feature    1854..2201
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SLED domain; Region: SLED; pfam12140"
                     /db_xref="CDD:463469"
     misc_feature    2271..2678
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMD2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2649..2651
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JMD2.2); phosphorylation site"
     misc_feature    2673..2675
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9JMD2.2); phosphorylation site"
     misc_feature    2694..2948
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SAM domain of Scm-like-4MBT1,2 proteins of Polycomb
                     group; Region: SAM_Scm-like-4MBT1,2; cd09581"
                     /db_xref="CDD:188980"
     misc_feature    2694..2948
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="SAM domain of Scm-like-4MBT1,2 proteins of Polycomb
                     group; Region: SAM_Scm-like-4MBT1,2; cd09581"
                     /db_xref="CDD:188980"
     misc_feature    order(2811..2819,2823..2828,2835..2840,2847..2852,
                     2865..2867)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface ML [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(2811..2819,2823..2828,2835..2840,2847..2852,
                     2865..2867)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface ML [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(2874..2885,2889..2894,2901..2903,2910..2912)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface EH [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     misc_feature    order(2874..2885,2889..2894,2901..2903,2910..2912)
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /note="putative oligomer interface EH [polypeptide
                     binding]; other site"
                     /db_xref="CDD:188980"
     exon            388..482
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            483..723
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            724..812
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1059
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1148
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1250
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1401
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1484
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1611
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1725
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1768
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1830
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1970
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2080
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2256
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2435
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2681
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2810
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..7822
                     /gene="Sfmbt1"
                     /gene_synonym="Sfmbt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atattggaat gagtcggagc gcggagcgcc gccgccgccg cctccgccgg agcgcgggtg
       61 caggggggcg gggagagctg ccggccgccc cgctctgccg ggcccagcag gaaggagggc
      121 gcgagcagta cgagcggaaa aggcgcctcg cgcgggcgag cgcaaagaag gaaagaaaga
      181 aaacgagcga gcgagcgtgc gagctagcag ggagagcgag caagcgcgcg cgcgaaaact
      241 cccgtcaggt ccttgggtgc cactgggtag aaacgtgaca cttcaggtca tctgtgtatc
      301 gcagcagagc cctcagcctg ctcatcactc ggggaagaga acacccatgt gctgtggaga
      361 tgaacggcga gcagcagctt gatgcagatc tcgggtctgg tgtagaagta gaggagttca
      421 gctgggaaga ttatctggaa gagacaggcg ccaccacagc tccctatgca tcgtttaaac
      481 atgtggatat atgtttgcaa agtgggtttg cccctgggat gaagctggag gtggctctga
      541 ggaaggaccc tgaaacttac tgggtggcca ccgtcattac ggcctgtgag cagctgctcc
      601 tgctccgcta cgaaggctat ggggaggacc ggaaggcaga cttctggtgc gacatcagga
      661 gagctggcct ctaccccatc ggctggtgtc agcagaacaa gaagaccctc gaagctcccg
      721 aaggcatcag agataaagtg tctgactgga gtgcattcct acagcggacc ctgacaggag
      781 cctgtggtcc ccctgtggct ctgctagagg gcctccgtaa cggaaggaat cctttagatc
      841 tcattgctcc gggatccaga ctagaatgcc aagattttcg ggactctgta agcacgtgga
      901 tagttactgt tgtggagaac attggaggac ggttgaagct gcagtatgaa ggacttgaaa
      961 ggcatgatgg ttttgaacac tggctatatt acttagatcc gtttcttcat cacattggct
     1021 gggctgctca gcaaggatac gaactccagc ccccattagc catcaggcat ctgaaaaatg
     1081 aagctgactg gcaagagatt ttggccagag tgaaagagga ggagccatta ccctcttact
     1141 tatttaagga taagcaagtt attagaaccc atgagttttc tataaacatg aagttggaag
     1201 ctgtggaccc atggtctcct tttgggattt ctcctgctac aattgctaag gtttttgatg
     1261 ataagtactt tctagtggaa atagatgacc ttcgaccaga agaccacgca aggcggtcat
     1321 ttgtgtgcca tgctaacagt cctggcatct ttcctgtgca gtggagtcta aagaatggtt
     1381 tacacatcaa ccctcctcca ggcttccgga gccaggactt tgactgggcc gactacctca
     1441 agcagtgtgg tgctgaagcc gctccccaga agtgcttccc gcagtcagtg tctgagcacc
     1501 agttcaagga gaacatgaag ctggaggcag tgaaccctct cttccctgaa gaagtgagca
     1561 tagccaccgt gactgcagtg agaggctctt acctgtggct ccagctggaa ggttctaaga
     1621 agcctgtacc cgagtttatt gtaagtgtgg agtcgatgaa tatatttcct ttgggctggt
     1681 gtgaaaccaa tggccatcct ctcagtactc ctcgccgggc acgagggcat aaactgagga
     1741 aaattgcagt ggttcaaccc gaaaaacaaa tactgtcttc aagaactgtc catgaaggcc
     1801 tgaagaatca gctgaactcc ccccactcag tgatgatcaa tggaaaatac tgttgtccaa
     1861 agatatactt caaccaccgt tgcttctcag ggccgtatct taataaagga agaattgctg
     1921 agctgcctca gtgtgtagga cctgggaact gtgttctggt ccttagagag gtccttactt
     1981 tgcttatcaa cgcagcatac aagcccagcc gtgtcctccg agagctccag ctggacaaag
     2041 actctgtgtg gcatgggtgt ggagaagtcc tgaaggccaa atataaaggg aagagctacc
     2101 gagctactgt tgagatagtg agaacagcgg accgagtgac ggaattctgc cggcaaacat
     2161 gtatcaaact ggaatgctgt cccaacctct ttggtccacg catggttctg gacacatgct
     2221 ctgagaactg ctctgtcctg acgaagacca aatacacaca ctattatgga aagaagaaaa
     2281 ataaaagaat tgggagacca cccggtgggc atagtaattt atcttgtgcc ctgaaaaaaa
     2341 ccagtaagag gagaaaaagg cggaaaaata tttttgttca taagaagaaa cgctcttctg
     2401 catctgttga caatacccca gtgggctcac cccagggaag cgggggtgag gatgaggatg
     2461 atgccgatga cggagatgat gattcgctca ctgagggcag tacatctgag caacaggacg
     2521 agttacatga agagtctgag gtgtcagaaa aaaaatcatg ctccccttct cccacccaga
     2581 gtgagatgtc caccccactg cccccagaca cacagacgga taaaagagag gcccagactt
     2641 cctcactctc agatggtgaa aacaagcctc cttcaccaaa ggaaataaga attgaagttg
     2701 atgaaaggct tcacctggac agtaacccac tgaagtggag tgtggccgac gtcgtgcggt
     2761 tcatcaggtc caccgactgc gctccgttgg caagaatatt ccttgatcag gaaattgatg
     2821 ggcaggccct cttgctcctt accctcccca ctgttcaaga gtgcatggac ttaaagttgg
     2881 gccccgccat caagctctgc catcacatag agagaatcaa gtttgcgttc tatgagcagt
     2941 ttgccaactg agaaggacaa gcagactgag ctgggtcttt gaagcacagt gcagcaagcc
     3001 ctttgccctg ctctacgggc agctgcagtc gtcctgggct atcggcctgc aagtgctggc
     3061 ttgctatctt tgcactttca gggaaggagg gagcaaaaag agcacaaaat ggctctcctg
     3121 caatggaatt gtggacttct gtttagaaga ttccagttta aaagtcgtga ggaagaaaaa
     3181 aaacccttaa aagtctgagt gaccattaac gggacctgaa atcaaagaat gactgtgaca
     3241 gctggaccac accaatttgg ttattttcat tctgttcctt ccctctgtag attgaactct
     3301 gttctctgct ttctctttgt tgaaaaaaga ggacatagct ttaagtcggc actggcttgg
     3361 gatggtgcct aaggcacggc agtgccccac tgttgttgtg tttttaagct tttctaaatt
     3421 aaagcagttc attttgggga tactgaagtg gctctagggt tttgaatgta tagtcacact
     3481 tcgatccatt ttaaaatctg tcttaggagt tcctttgttt actacctctg ttgatgactg
     3541 cgcttacagc catgagtgac attttttgta cgatgccatt tttaagctga atgctaaaac
     3601 tatgacagaa attagagacg gcactgcctg cttttttaaa ggtatcgtgt cagcacctac
     3661 accccagccc cttcaccagc tgtcctagga attccactct tgtgtcctcc attgtcaccc
     3721 agttttggcc accgctgtta agtggcttta caaagtattt cagtcttcac tccccccccc
     3781 ccacccgtta tttctgaaag gtatttaagt ggctttggtt ttatgcttag ttttctgtag
     3841 agttgtttaa ctacctctgt ttaatttctg gaatttctac tctcagtgaa aatgagtgtg
     3901 tgttctttgg acccactgtc gagcccattt ttctggtttt ctgggtatgt ccaagtagac
     3961 acatggcaga gaaatgtgtc tttggggatg gcacaaagta tgaagtttgt taacagtgtc
     4021 ctcggttgtg agtactgaga ggtagttaag agtctatgac cacgctaccc gaaatgtccc
     4081 catcttctct cctctggaaa gctaagcagg gcctggttgg tacttggatg ggagatgtgg
     4141 ttaagaagtc tagaaatctc tgtctagcca cggttatgcc tgtcttcagt taagccaatt
     4201 taaattgaat gtcattacag tctgaagatt cccactcagt agctcattct tttgaagttt
     4261 ttctttttct ttttaattaa actcaagttg acatgaagct ccaggtgaat tttcacttac
     4321 aatggcgttg ttcagttatt accgaagaat agcatttgat ctaccacagc caggagtaaa
     4381 gaaagacatg cagacacagt tgcctccttt aaagttttcc ttgttgatta tttatttatt
     4441 tatttttgat taccctaatc cctacagatt tataccctaa acatttttcc tcaagaattg
     4501 aaaatgtttt aaaactgcaa acggagtaaa ttctgaacaa gcatacaaat ataaggtcat
     4561 atcattacaa acttaaattg tgattttttt tcttttctca cctcaactcc acctgttttt
     4621 atggaccctg ggaacgtctg tagtgtggat ccccctcttc cttggataac cgtctaaccg
     4681 agtcttaaag cagcagctct tcacataggc caccagcagg tgtctctggg aagaagcttc
     4741 atttaagtaa tggttcagtt atttgagctt tcttagagat ccatcttcta aaaacataat
     4801 tctctgatgc catggagaga ggcagacatg gtactaggga gcagattggc agactgacat
     4861 gcgtggctct tcttagaatc tccggagact gcaggagttg agtcactgat acaaagggga
     4921 gtcatgagag gacatagaac ccatgcctac agggtctcac actgttacct tagtgaaatg
     4981 aaaggggaca gcattgactc taatttacct ctctccttga ctcagatcac agaacgtaga
     5041 gctaccagag ataacaggta ttctgtctgg aaggtgaagc acacgaccca aggcctgagt
     5101 ggggctgggg gctgggggga aacacaacag tcttgtctta ggctaccata attactcaat
     5161 ctctgtgtaa gttagacaag aggagggctt ccctgaatat gtcttgcact tgtgttggga
     5221 taccatacac ttgacagtcc tagcaaagaa tcatctatcc caactttctt cacacagaag
     5281 aggacaatta aatggggatt ttgcagagga cctttaagta taaaattcta atctcaaact
     5341 gggtacggtg atattcacct ttaatcccaa tatttgggaa gaggaaatgg ggaatcagaa
     5401 gtctaagatc aaccttggct acatagtgaa ttctaggcta gcccaggtta tgtgcgatcc
     5461 tgcctttttt aaagattgtt ttcatttcat gtatctataa agatacaaag gttaggctag
     5521 gtagcagtaa tggttatgat gctggggtgt tttaagtttg atgatagctt gcattgttgg
     5581 ggtaaatagt ttacatgtta cacatttgta tgggaaactg tctctgagac agccagcctc
     5641 aaaattcata gatgtttgct gtaaggagac tctttgtcta gagttcacct gcagttgttc
     5701 tcatagcttg cctgcagtca agttttttat gatccacctt aaacctggtt gacaaactta
     5761 gaaatacatg aacagactat attgtcctcc tagacctcaa gacttaacag acccaaacta
     5821 gactttacag ctatattggt cttctaggga aaccttcaac tgtatgtgca gattagttct
     5881 gatattttga ctatatatgc tgtttccctt tgtgaaatgt ctttgtcctt tttaaatata
     5941 ggagatacat taatggagcc ctttaattac atctttagcc tttctttagc aatgtacaca
     6001 gctccctgtt tttataatac aggcgtagga agggtactag ccaagctcta gaagtgaaga
     6061 tcttggtaaa tatttattga attttaatag aggcaggcat agaaaaccag ttcagagttt
     6121 gacctttgta tgtctcttcg agagataaaa gtattttcac tgtgagggaa agggcattcg
     6181 accaaagctt cctgaagact tgaatacctt ttacatgctc tttggaacca ctgtagttac
     6241 taatgtgaag cctgaagaag gcagatagga ctcaaaacat cccacccctc gcaagccaac
     6301 actgtttcca agagacacag aaaatgaggc agtctaaacc ataggtggta gcactgtaaa
     6361 aactattgta gaatcatgaa aactgttact gggacttatt cttagctggc acctctcacc
     6421 aaagcttaca ttgaagagat cttgtccagt ctgagtgact gccaccagtg ctgggagagt
     6481 ccttagactg tgaaagtaac actgagtttg aacttgcctt acacactggg aatattctct
     6541 gtgtacaaag tcacacacgt tcctacgcgt tcttgtgaag aagtgaagta gagaacttgg
     6601 gcagacaaga tgatcacttt gtaaacttgg atgtctctgg tcctaggacc ttggtaagtt
     6661 ctgtgtcttg tgaccgtgat gctggctcag aaactctgta agaacagagc ctcctgtaca
     6721 accaagaaat gatggtcact ttcctgccat tggcttcatt ttaaatgttt tactcgtgaa
     6781 cattgatgac tgctttgtgt gagaatgtat gtacttgggg agtttgaatt tattctaata
     6841 agctacctgt tgacctggag tttcattcta aggattctaa gctcaaagcg cagtccagat
     6901 ggatctggtt ccaggtgcac tcacttgtac tgtcttcagc cacaaaggtc agaatcacaa
     6961 gaaccagcaa caccagggtg aaggtttgta ggggaggttg ggggattaaa gtagctctaa
     7021 aactctctta ctttttctga tgaggctggt gtggtgggta caatggccta ccatggcgaa
     7081 gtgttatgaa agagacaagc aacggattca ccagacagtt gtcattacca gcagtaaagt
     7141 gtggaatgga gccatgggaa acaaggaagc aagcaaggga gggagggaac ttctgacaga
     7201 gaaacagtgt caccattgct gaggtgtgag agaggaactt ctctccgtgt gtggaaactc
     7261 aggccgtagg gctcctgtag ggcttattct gtctagcttg gcagaattga gggggtcaca
     7321 taatgtcaca acaaggttat agactttaag ggcaggtcac aacgcagatg atcagcagag
     7381 gacacagaca tttacaaagc ccaggctggg gtaaagcagg cagtctcctg tccccttttg
     7441 taagagtttt aagtgctcgt gtttccctcc cacttccctc cctaaagaca atcaggggct
     7501 cgccaggatg ggactccagg ctgcttccag caccgtcctt agccctctct ccagtactct
     7561 ctctttggaa gaaatgcact ttgtttaatg tatttgcctt taaaaaacca aaacaagttg
     7621 cttgtctgga acaaaatgag atgcttttgg cactgtatca ttcctgcttg ctgtttttcc
     7681 tcttaattta aaattttatg cattgaagac aaagtacatt taaggagaaa tatgcacaag
     7741 aatacctatt aaaataactc ccatcaggtt tgatggtata attttaaagg attaaaaaca
     7801 aaacaaaact attttgaatg aa
//
LOCUS       NM_001105993            1993 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus glomulin, FKBP associated protein (Glmn),
            transcript variant 1, mRNA.
ACCESSION   NM_001105993 XM_001057583 XM_213992
VERSION     NM_001105993.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Krummrei,U., Baulieu,E.E. and Chambraud,B.
  TITLE     The FKBP-associated protein FAP48 is an antiproliferative molecule
            and a player in T cell activation that increases IL2 synthesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2444-2449 (2003)
   PUBMED   12604780
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Brouillard,P., Boon,L.M., Mulliken,J.B., Enjolras,O., Ghassibe,M.,
            Warman,M.L., Tan,O.T., Olsen,B.R. and Vikkula,M.
  TITLE     Mutations in a novel factor, glomulin, are responsible for
            glomuvenous malformations ('glomangiomas')
  JOURNAL   Am J Hum Genet 70 (4), 866-874 (2002)
   PUBMED   11845407
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Grisendi,S., Chambraud,B., Gout,I., Comoglio,P.M. and Crepaldi,T.
  TITLE     Ligand-regulated binding of FAP68 to the hepatocyte growth factor
            receptor
  JOURNAL   J Biol Chem 276 (49), 46632-46638 (2001)
   PUBMED   11571281
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Chambraud,B., Radanyi,C., Camonis,J.H., Shazand,K., Rajkowski,K.
            and Baulieu,E.E.
  TITLE     FAP48, a new protein that forms specific complexes with both
            immunophilins FKBP59 and FKBP12. Prevention by the
            immunosuppressant drugs FK506 and rapamycin
  JOURNAL   J Biol Chem 271 (51), 32923-32929 (1996)
   PUBMED   8955134
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474079.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057583.1, XM_213992.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMN12840122 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1993
                     /gene="Glmn"
                     /note="glomulin, FKBP associated protein"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
     exon            1..77
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            78..153
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    106..108
                     /gene="Glmn"
                     /note="upstream in-frame stop codon"
     CDS             115..1905
                     /gene="Glmn"
                     /note="FKBP associated protein"
                     /codon_start=1
                     /product="glomulin"
                     /protein_id="NP_001099463.1"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
                     /translation="MAVEELQCIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQ
                     LLEIIQDEKNKTIIKTMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELL
                     LGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSAGLALSTLWSQLSLLPVP
                     HSEEQIQADDYGLCQCCRALIEFTKPFVAEVASDKEDPANTKLKDELLKFCFKSLKCP
                     LLTAQFLEQSEEVGNDPFRCFASEIIGFLSQIGYPVPQIILNHGRKKRTWDYLEFEEE
                     EDRQLADSVAALTYLVFVQGIGTDQLPMVLSPSYLLQLNMEHIEVLLQRTEQSVYSKG
                     LELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKTGLAMLQLYID
                     KLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSYKKTHNRWFAGAQLTSLLDL
                     VLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLQPLH
                     VGLNMSKAHYEAEIKNSQQNSQAASMCKSVCSVTVGGEEIPTMPPEMQLKVLHSALFT
                     FDLIESVLARVEELIEIKSKSTSEENAGMK"
     misc_feature    115..1686
                     /gene="Glmn"
                     /note="Uncharacterized protein family, YAP/Alf4/glomulin;
                     Region: Kinetochor_Ybp2; pfam08568"
                     /db_xref="CDD:400745"
     misc_feature    115..1686
                     /gene="Glmn"
                     /note="Uncharacterized protein family, YAP/Alf4/glomulin;
                     Region: Kinetochor_Ybp2; pfam08568"
                     /db_xref="CDD:400745"
     exon            154..279
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            280..396
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            397..505
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            506..743
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            744..846
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1034
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1088
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1119
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1209
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1251
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1325
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1410
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1517
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1581
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1705
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1788
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1993
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacctggga agaggctctt gttcgtaccg gtagcgactc ggtgggtgct ggaagcccgg
       61 gcacttgggc ccagagattc atttcagcat caaaactagg aaaagtaatt aggaatggct
      121 gtggaggaac ttcagtgcat aataaaaaga tgtcaaatcc tagaagagca tgattttaaa
      181 gaagaagatt ttggcctctt tcagctagca ggccaaagat gcattgaaga tgggtatata
      241 aaccagctgc tagagattat tcaagatgaa aagaacaaga ccatcattaa gactatgggg
      301 tggaatcttg ttggtcctgt tgtccgatgc ctcctgaggg gcagggaaga ggataaaaga
      361 gaagagtgtt ttctgatctt tgatttgctg gtgaagttgt gtaatccaaa ggaattgttg
      421 ttgggtttgc ttgaactcat tgaagagccc tccgggaaac agatatctca aattattctt
      481 cttttactgc aaccattaca gacagttatt cagaaacttc ctaacaacaa ggcatactcg
      541 gctggattag cattgtccac gctctggagt cagctgtctc ttcttcctgt cccacactca
      601 gaagaacaaa tacaggcaga tgactatggc ctttgtcagt gttgcagggc cttgatagag
      661 ttcacgaaac cctttgtggc agaagttgct agtgataaag aagacccagc aaacacaaag
      721 ctgaaggatg aactactgaa attctgtttc aaaagcttga aatgcccttt gctgacagca
      781 caattcctcg aacagtctga agaagttgga aatgaccctt tccggtgttt tgcatctgaa
      841 ataataggat ttttatcaca aattggatat cctgtccccc aaattattct taatcatgga
      901 aggaaaaaaa ggacttggga ttaccttgaa tttgaagaag aagaagacag acaactggca
      961 gactctgtgg ctgctctgac atacctagtc tttgttcagg gcatcggtac cgaccagctt
     1021 cccatggtct taagcccttc ataccttttg cagttgaaca tggagcacat tgaagtgctt
     1081 ctgcaaagaa cagaacagtc tgtttactcc aaaggcttgg aactgctgga gactagctta
     1141 ttgagattag aagacaacag cctatgttat cagtacctag aaatcaagag tttccttgct
     1201 gtgcctcagg gcttagtcaa agtcatgaca ctctgtccca ttgagacact gaggaaaaca
     1261 gggttagcca tgcttcagct gtacatcgac aagttggact cccaaggcaa atacacatta
     1321 tttaggtgct tactaaatac gagtaatcac tcaggtgtgg aagcctttgt aattcaaaat
     1381 atcaaaaatc agattgattt atcatataag aaaacccata acaggtggtt tgcaggcgca
     1441 cagctgacct ctctgttaga cctggtcctg tccctccctg agggcgctga gacagattta
     1501 ctgcagaact cagaccggat tatggcttca ctaaatttgt tgaggtattt ggttatcaaa
     1561 gataatgaag atgacaacca aactggatta tggacagagc ttggaaagat tgaaaataac
     1621 tttctacagc cacttcatgt aggacttaat atgtcaaagg cacattatga agcagagatt
     1681 aaaaacagcc aacaaaatag ccaagctgcc tcaatgtgta aaagtgtttg ttctgtgact
     1741 gtaggcggag aagaaatccc cactatgcct cctgagatgc agcttaaggt cttacattcc
     1801 gccctcttca cattcgactt gattgaaagt gtcctggctc gagtcgaaga actcattgaa
     1861 atcaaatcaa agtctacctc tgaggaaaac gctgggatga agtaaaagct ctacttcatg
     1921 aataaaaacc aataaaatgc catttttcat tatagtttat actgccataa aatagttgca
     1981 gaaattttac tac
//
LOCUS       NM_001436934             615 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 27 (Ccl27), transcript
            variant 1, mRNA.
ACCESSION   NM_001436934 XM_006238077
VERSION     NM_001436934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 615)
  AUTHORS   Maerki,C., Meuter,S., Liebi,M., Muhlemann,K., Frederick,M.J.,
            Yawalkar,N., Moser,B. and Wolf,M.
  TITLE     Potent and broad-spectrum antimicrobial activity of CXCL14 suggests
            an immediate role in skin infections
  JOURNAL   J Immunol 182 (1), 507-514 (2009)
   PUBMED   19109182
REFERENCE   3  (bases 1 to 615)
  AUTHORS   Baumer,W., Seegers,U., Braun,M., Tschernig,T. and Kietzmann,M.
  TITLE     TARC and RANTES, but not CTACK, are induced in two models of
            allergic contact dermatitis. Effects of cilomilast and diflorasone
            diacetate on T-cell-attracting chemokines
  JOURNAL   Br J Dermatol 151 (4), 823-830 (2004)
   PUBMED   15491423
REFERENCE   4  (bases 1 to 615)
  AUTHORS   Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H., Asano,N., Mitsui,H.,
            Tada,Y., Wakugawa,M., Watanabe,T., Torii,H., Komine,M., Asahina,A.,
            Nakamura,K. and Tamaki,K.
  TITLE     Increased serum cutaneous T cell-attracting chemokine (CCL27)
            levels in patients with atopic dermatitis and psoriasis vulgaris
  JOURNAL   J Allergy Clin Immunol 111 (3), 592-597 (2003)
   PUBMED   12642842
REFERENCE   5  (bases 1 to 615)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
REFERENCE   6  (bases 1 to 615)
  AUTHORS   Gortz,A., Nibbs,R.J., McLean,P., Jarmin,D., Lambie,W., Baird,J.W.
            and Graham,G.J.
  TITLE     The chemokine ESkine/CCL27 displays novel modes of intracrine and
            paracrine function
  JOURNAL   J Immunol 169 (3), 1387-1394 (2002)
   PUBMED   12133963
REFERENCE   7  (bases 1 to 615)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 615)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 615)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006238077.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF978637.1, SRR26360181.2112375.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000005.1  61741780-61741850   c
            72-139              JAXUCZ010000005.1  61741422-61741489   c
            140-199             JAXUCZ010000005.1  61741152-61741211   c
            200-297             JAXUCZ010000005.1  61738859-61738956   c
            298-430             JAXUCZ010000005.1  61737621-61737753   c
            431-615             JAXUCZ010000005.1  61737261-61737445   c
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..615
                     /gene="Ccl27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
     exon            1..71
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Ccl27"
                     /note="upstream in-frame stop codon"
     exon            72..139
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..587
                     /gene="Ccl27"
                     /note="isoform a is encoded by transcript variant 1; C-C
                     motif chemokine 27; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform a"
                     /protein_id="NP_001423863.1"
                     /db_xref="GeneID:362505"
                     /db_xref="RGD:1304660"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSPMPPTSQR
                     LSLEPPRLPLTGWHPWNKTKEKQEALPLPSSTSCCTQLYRQPLPTRLLRRIVRVELQE
                     ADGDCHLQAVVLHLTRRSVCVHPQNRSLARWLERHGKRLQGTLPSLNPVLQKKMCPSP
                     QKQK"
     misc_feature    318..500
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     misc_feature    318..500
                     /gene="Ccl27"
                     /note="Small cytokines (intecrine/chemokine),
                     interleukin-8 like; Region: IL8; pfam00048"
                     /db_xref="CDD:459650"
     exon            140..199
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            200..297
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            298..430
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
     exon            431..615
                     /gene="Ccl27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccgtttc cggggcggag ccagggaggg cggggagttt aggctgtacc gacccctgag
       61 ccccccttca ggaaccgttc ggagctcgag acatgtcgcg attgaggaga tacgaggtgg
      121 cgctggaagc ggaggaggag atctactggg gctgcttcta cttttttcct tggctgcgaa
      181 tgtggcgcag ggagcggagt ccgatgcctc caacaagcca gagactaagt ctggaacccc
      241 ccaggctccc gctgacaggc tggcatccgt ggaacaagac taaggagaag caagaagcct
      301 tgccactgcc ctccagcact agctgctgta ctcagctcta taggcaacca ctcccaacca
      361 gactactgag gaggatcgtc cgtgtggagc tgcaggaggc tgacggggac tgccacctcc
      421 aagctgttgt gcttcacctg actcggcgca gtgtctgtgt tcatccccag aaccgtagcc
      481 tggctcggtg gttagaacgc catgggaaaa ggctccaggg gaccctaccc agtttaaatc
      541 cggtactaca aaagaaaatg tgcccgagcc cccaaaagca aaagtaataa agcaacatta
      601 gacgataatc tccaa
//
LOCUS       NM_001436902            7637 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, F
            (Ptprf), transcript variant 1, mRNA.
ACCESSION   NM_001436902 XM_039110159
VERSION     NM_001436902.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7637)
  AUTHORS   Dyck,S., Kataria,H., Akbari-Kelachayeh,K., Silver,J. and
            Karimi-Abdolrezaee,S.
  TITLE     LAR and PTPsigma receptors are negative regulators of
            oligodendrogenesis and oligodendrocyte integrity in spinal cord
            injury
  JOURNAL   Glia 67 (1), 125-145 (2019)
   PUBMED   30394599
  REMARK    GeneRIF: In a spinal cord injury model, blocking LAR and PTPalpha
            receptors promotes oligodendrogenesis.
REFERENCE   2  (bases 1 to 7637)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: This study showed that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 7637)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7637)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   5  (bases 1 to 7637)
  AUTHORS   Song,Y.S., Lee,H.J., Prosselkov,P., Itohara,S. and Kim,E.
  TITLE     Trans-induced cis interaction in the tripartite NGL-1, netrin-G1
            and LAR adhesion complex promotes development of excitatory
            synapses
  JOURNAL   J Cell Sci 126 (Pt 21), 4926-4938 (2013)
   PUBMED   23986473
REFERENCE   6  (bases 1 to 7637)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Increased abundance of specific skeletal muscle protein-tyrosine
            phosphatases in a genetic model of insulin-resistant obesity and
            diabetes mellitus
  JOURNAL   Metabolism 44 (9), 1175-1184 (1995)
   PUBMED   7666792
REFERENCE   7  (bases 1 to 7637)
  AUTHORS   Ahmad,F., Considine,R.V. and Goldstein,B.J.
  TITLE     Increased abundance of the receptor-type protein-tyrosine
            phosphatase LAR accounts for the elevated insulin receptor
            dephosphorylating activity in adipose tissue of obese human
            subjects
  JOURNAL   J Clin Invest 95 (6), 2806-2812 (1995)
   PUBMED   7769120
REFERENCE   8  (bases 1 to 7637)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 7637)
  AUTHORS   Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E.
  TITLE     Cloning, bacterial expression, purification, and characterization
            of the cytoplasmic domain of rat LAR, a receptor-like protein
            tyrosine phosphatase
  JOURNAL   J Biol Chem 266 (29), 19688-19696 (1991)
   PUBMED   1918076
REFERENCE   10 (bases 1 to 7637)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110159.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14188.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  137109266-137109453 c
            189-268             JAXUCZ010000005.1  137102816-137102895 c
            269-403             JAXUCZ010000005.1  137095316-137095450 c
            404-549             JAXUCZ010000005.1  137087255-137087400 c
            550-691             JAXUCZ010000005.1  137086942-137087083 c
            692-880             JAXUCZ010000005.1  137074901-137075089 c
            881-991             JAXUCZ010000005.1  137066584-137066694 c
            992-1261            JAXUCZ010000005.1  137056469-137056738 c
            1262-1843           JAXUCZ010000005.1  137054602-137055183 c
            1844-1980           JAXUCZ010000005.1  137054243-137054379 c
            1981-2125           JAXUCZ010000005.1  137053623-137053767 c
            2126-2431           JAXUCZ010000005.1  137049945-137050250 c
            2432-2625           JAXUCZ010000005.1  137049152-137049345 c
            2626-2743           JAXUCZ010000005.1  137045007-137045124 c
            2744-3322           JAXUCZ010000005.1  137044353-137044931 c
            3323-3420           JAXUCZ010000005.1  137043586-137043683 c
            3421-3674           JAXUCZ010000005.1  137043147-137043400 c
            3675-3768           JAXUCZ010000005.1  137042968-137043061 c
            3769-3987           JAXUCZ010000005.1  137042165-137042383 c
            3988-4142           JAXUCZ010000005.1  137041639-137041793 c
            4143-4258           JAXUCZ010000005.1  137039093-137039208 c
            4259-4291           JAXUCZ010000005.1  137036798-137036830 c
            4292-4389           JAXUCZ010000005.1  137035917-137036014 c
            4390-4513           JAXUCZ010000005.1  137032859-137032982 c
            4514-4689           JAXUCZ010000005.1  137032561-137032736 c
            4690-4809           JAXUCZ010000005.1  137031787-137031906 c
            4810-4964           JAXUCZ010000005.1  137031401-137031555 c
            4965-5250           JAXUCZ010000005.1  137031039-137031324 c
            5251-5429           JAXUCZ010000005.1  137030760-137030938 c
            5430-5556           JAXUCZ010000005.1  137030412-137030538 c
            5557-5682           JAXUCZ010000005.1  137030057-137030182 c
            5683-5837           JAXUCZ010000005.1  137029744-137029898 c
            5838-5973           JAXUCZ010000005.1  137029514-137029649 c
            5974-7637           JAXUCZ010000005.1  137027376-137029039 c
FEATURES             Location/Qualifiers
     source          1..7637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7637
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="protein tyrosine phosphatase, receptor type, F"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
     exon            1..188
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    64..66
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="upstream in-frame stop codon"
     exon            189..268
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..403
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..6042
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase F;
                     leukocyte antigen-related (LAR) PTP receptor; leukocyte
                     common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     isoform 1 precursor"
                     /protein_id="NP_001423831.1"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
                     /translation="MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSS
                     YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVR
                     VSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQ
                     IRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGA
                     RSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARP
                     NTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAPSGFPQNLR
                     VTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVHLTLLGLKPD
                     TTYDIKVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYK
                     SAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAP
                     DLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPE
                     ELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRP
                     LSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAV
                     ILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAP
                     SCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNK
                     PKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF
                     WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRT
                     FALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSA
                     GVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
                     MCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKF
                     KNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW
                     RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF
                     KVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCS
                     AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
                     LGSFDHYAT"
     sig_peptide     313..399
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    409..684
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:400151"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    460..474
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    499..513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    568..591
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    622..639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..672
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    661..663
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..990
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Second immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F; member of
                     the I-set of IgSF domains; Region:
                     IgI_2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    718..726
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    739..753
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    760..789
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    802..822
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    826..834
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    859..873
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    880..897
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    922..945
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    952..987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409400"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1260
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F (also known
                     as LAR), type IIa; member of the I-set of IgSF domains;
                     Region: IgI_3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1015..1023
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1033..1047
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1054..1080
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409401"
     misc_feature    1060..1062
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1093..1113
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1117..1125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1132..1146
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1159..1176
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409401"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1174..2448
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1218
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409401"
     misc_feature    1195..1197
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    1228..1257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409401"
     misc_feature    2086..3462
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2086..3462
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    2389..2451
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2473..2475
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3133..3135
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    3181..3183
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); glycosylation site"
     misc_feature    4075..4137
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64604.1);
                     transmembrane region"
     misc_feature    4198..4200
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10586; propagated from
                     UniProtKB/Swiss-Prot (Q64604.1); phosphorylation site"
     misc_feature    4321..5148
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    4321..5148
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    5152..6024
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     misc_feature    5152..6024
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="PTP-like domain of receptor-type tyrosine-protein
                     phosphatase F, repeat 2; Region: R-PTP-F-2; cd14629"
                     /db_xref="CDD:350477"
     exon            404..549
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            550..691
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            692..880
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            881..991
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1261
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1843
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1980
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2125
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2431
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2625
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2743
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..3322
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3420
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3674
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3768
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3987
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4142
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4258
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4291
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4292..4389
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4513
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4689
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4690..4809
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..4964
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5250
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5429
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5430..5556
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5557..5682
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5683..5837
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5838..5973
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5974..7637
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcggtg gcggcggcgg cagaggcggc ggctccggct ccagctccgg ctccggctcc
       61 tgttagggcg gcggtggagg tggcggtggc ggtggcggga gcgggcgacg gcggcagcgg
      121 cggactgaga acggcggcct cagcggcgcg aggcggggac atgcagaccg acggcccccg
      181 gagaggcgga aggagcggag gccctggtgc cctgccctca gtgctgactg cccagcgaga
      241 gtgactggta taaacaagaa gagaccgggt gattgtcttg ggctgtggct ggctgtggag
      301 ctagaaccct ggatggcccc cgagccagcg ccagggagga ggatggtgcc ccttgtgcct
      361 gccctcgtga tgctgggttt gatggcaggt gctcatggcg acagcaaacc tgtctttgtt
      421 aaggtccccg aggaccagat cgggctgtcg ggaggggtgg cctccttcgt gtgccaagcc
      481 acaggggaac ccaagcctcg aatcacatgg atgaagaagg gaaagaaagt cagctcccag
      541 cgctttgagg taattgagtt tgacgacgga gcagggtcag tgctgcggat ccagccatta
      601 cgagtgcagc gagacgaagc catctatgag tgcacggcca cgaacagtct cggcgagatc
      661 aacacaagtg ccaagctgtc agtacttgaa gaggaccagc tgccgtctgg gttcccgact
      721 atcgacatgg gacctcaact gaaggtggtg gagaaggctc gcactgccac catgctgtgt
      781 gcagctggtg gaaatccaga ccctgagatc tcttggttca aagacttcct tcctgtggac
      841 cctgcttcaa gcaacggtcg tatcaagcag ctgcgttcag gtgcattgca gattgagagc
      901 agcgaggagt ctgaccaagg caagtacgag tgtgtggcaa ccaactcggc aggcacacgc
      961 tactcggccc ccgccaacct gtatgtgcga gtgcgccgcg tggctcctcg tttctccatc
     1021 cctcccagca gccaagaggt aatgccgggc ggcaacgtga acctcacgtg tgtggcagtg
     1081 ggagcaccca tgccgtatgt gaagtggatg atgggcgccg aggaacttac caaagaggac
     1141 gagatgccag ttggccgcaa tgtgctggag ctcagcaatg tcatgcggtc tgccaactat
     1201 acctgtgtgg ccatctcttc actgggcatg atagaggcca cagcccaggt cacagtaaaa
     1261 gctctgccaa agcctccaat tgatcttgtg gtgacagaga caactgccac cagtgttacc
     1321 ctgacatggg actctggaaa taccgagcct gtgtctttct acggcatcca gtaccgtgca
     1381 gctggcacag atggcccctt ccaggaagtg gatggtgtgg ccagcacccg atacagcatt
     1441 ggtggcctca gccctttttc agaatatgcc ttccgtgtgt tggctgttaa cagcattggg
     1501 cgaggaccac ccagtgaggc agtgcgagcg cgcacgggtg agcaggcacc ctccagccct
     1561 ccacgccgtg tgcaggcccg aatgctgagc gccagcacca tgctggtaca gtgggaaccc
     1621 cctgaagagc ccaatggcct ggtacgggga tatcgagtct actacacccc agactctcga
     1681 cgccccttga gcgcctggca caagcataac accgacgcag gactccttac caccgtgggc
     1741 agcctgctac ctggcatcac ctacagcctc cgcgtcctgg cctttactgc cgtgggcgac
     1801 ggccctccca gccccaccat ccaagtcaag acacagcagg gagtgcctgc acagcctgca
     1861 gacttccagg ccaaagccga gtcggacacc aggatccagc tatcatggct gctgcccccg
     1921 caggagcgga tcatcaagta tgagctggtg tactgggcag cagaggatga aggccagcag
     1981 cacaaggtga ccttcgaccc cacctcctcc tacactctgg aggacctgaa gcctgacaca
     2041 ctgtaccact tccagctggc tgctcgctca gatttggggg tgggcgtctt cactcccacc
     2101 gtagaggccc gtacagcaca gtccacccca tccgcccctc cccagaaggt gacatgtgtg
     2161 agcacgggct ccaccacggt ccgggtaagt tgggttccac cgccggctga cagccgcaac
     2221 ggcattatca cccagtactc cgtggcctat gaggcagtgg acggcgagga ccgtaaacgg
     2281 catgtggtgg atggcatcag ccgtgagcat tccagctggg acctgttggg cctggagaag
     2341 tggacggagt accgggtgtg ggtgcgggca cacacagatg tgggccctgg ccctgagagc
     2401 agcccggtgc tggtgcgcac cgacgaggac gtgcctagcg ggccaccacg gaaggtggag
     2461 gttgagcctc tgaactccac tgctgtgcat gtctcctgga agctgcccgt ccccaacaag
     2521 cagcacggac agattcgtgg ctaccaggtc acctatgtgc ggctggagaa tggggagccc
     2581 cgaggccagc ccatcatcca ggatgtcatg ctggctgagg ctcaggaaac caccatcagc
     2641 ggcctcaccc ccgagaccac ctactccatt actgttgctg cctacaccac taagggggac
     2701 ggtgcccgaa gcaagcccaa agtggttact accacagggg cagtcccagg acggcccacc
     2761 atgatggtca gcaccacggc catgcacacc gcgctgctgc agtggcaccc acccaaggag
     2821 ctgcctggag agctgctggg ctaccggcta caataccgtc gggccgacga ggcgcggccc
     2881 aacaccatag attttggcaa ggatgaccag cattttacag tcaccggtct gcacaaaggg
     2941 gccacctaca tcttccggct ggctgccaag aaccgggctg gcccaggtga agagtttgag
     3001 aaagagatca cgacccccga ggatgcgccc agtggctttc ctcaaaacct ccgagtgaca
     3061 ggactgacca cgtctaccac ggaactggcc tgggacccgc cggtgctggc agagaggaat
     3121 ggtcgcatca ccaactatac cgtggtctac cgtgacatca acagccagca tgaactccag
     3181 aatgtcactg gtgatgtaca ccttacactc ttgggcctca aaccggacac cacttatgac
     3241 atcaaggtcc gtgcacatac cagcaaaggc gccggcccac tcagccccag catccagtcc
     3301 cagaccatgc ccatggagca agtgtttgcc aagaatttcc gtgtggccgc tgcaatgaag
     3361 acatctgtgc tgctcagttg ggaggtcccc gactcttaca agtcagctgt acccttcaag
     3421 atcctgtaca atgggcagag cgtggaggtg gatgggcact ccatgcggaa gctgattgca
     3481 gacctgcaac ccaacacgga gtactccttc gtcctgatga accgcggcag cagcgctggg
     3541 ggcctacagc acctggtgtc catccgcact gccccagacc tcctgcctca gaagccactg
     3601 cctgcctctg cctttataga ggatggccgc ttctccctct ccatgcctca agtgcaggac
     3661 ccctcgctag tcaggtggtt ctacattgtg gtggtgccca ttgaccgtgt gggcgggaac
     3721 ctgctggcac caagatggag cacaccagag gagctggagc tggacgagct tctggaggcc
     3781 atcgagcagg gtgaggagaa acagcggagg cgtcggcgcc aagcagagcg gctgaagcct
     3841 tacgtggcag ctcaagtgga cgagctccct gagaccttca ccctggggga caagaagaac
     3901 taccgtggct tctacaaccg gcccctgtct ccggatctga gttaccagtg ctttgtgctc
     3961 gcctccctca aggaacccat ggaccagaag cgctatgcct ccagccccta ctcggacgag
     4021 atcgtagtcc aggtgacacc agcccagcag caggaggagc ccgagatgct gtgggtgaca
     4081 ggccctgtcc tggcagtcat tctcatcata ctcattgtca tcgctatcct cctattcaag
     4141 aggaagagaa cacattcccc atcgtcaaag gatgagcagt caatcgggct gaaggactcc
     4201 ctgttggccc actcttctga ccctgtggaa atgcgaaggc ttaactacca gaccccaggt
     4261 tccagtgccc ccagttgccc gaatatctca agtatgcgag accacccgcc catccccatc
     4321 actgacctgg cagacaatat tgaacgtctc aaagccaatg atgggctcaa gttctcccag
     4381 gagtatgagt ccattgaccc tggacagcag ttcacgtggg agaattccaa ctcagaggtg
     4441 aacaagccca agaaccgcta tgcaaacgtc attgcctatg accactctcg agtcctcctc
     4501 acctccattg atggtgttcc tgggagtgac tacatcaatg ccaactacat tgatggctac
     4561 cgaaagcaga atgcctacat cgccacacag ggtccgctgc ctgagaccat gggtgatttc
     4621 tggaggatgg tgtgggaaca gcgtacagcc acagtggtca tgatgaccag gctagaggag
     4681 aaatcccggg tgaagtgtga tcagtattgg ccagcccgtg gcactgagac ctatggcctc
     4741 attcaggtga ccctggtgga cactgtggag ttggccacgt acaccatgcg caccttcgca
     4801 ctccataaga gcggctccag tgagaagcgt gagctgcgtc agttccagtt catggcctgg
     4861 ccagaccatg gggttcctga gtaccccact cccatcttgg ccttcctgag acgggtcaag
     4921 gcctgtaacc cgctagatgc aggacccatg gtggtgcatt gcagtgctgg tgtgggccgc
     4981 acgggctgct tcattgtcat cgacgcaatg ctggagcgta tgaagcacga gaagacagtt
     5041 gacatctatg gccacgtgac gtgcatgcgc tcgcaaagga actacatggt gcagacagag
     5101 gaccagtatg tgttcatcca cgaggcactg ttagaggctg ccatgtgcgg acacactgag
     5161 gtgcttgctc gaaacctcta tgcccacatc cagaagctag gccaagtgcc tcccggggag
     5221 agtgtcactg ccatggagct tgagttcaag ttgctggcca actccaaggc ccacacgtct
     5281 cgcttcatta gtgccaacct gccctgcaac aagttcaaga accgcctggt gaacatcatg
     5341 ccctatgagc tgactcgagt gtgcctgcaa cccatccgtg gtgtggaggg ctctgactac
     5401 atcaatgcca gctttctaga tggctacaga cagcagaagg cctacatagc tacacagggg
     5461 cctctggccg agagcaccga ggacttctgg cgcatgttat gggagcacaa ttccaccatc
     5521 atcgtcatgc tgacgaagct tcgggagatg ggcagggaga aatgtcacca gtactggcca
     5581 gcagagcgct ctgctcgcta tcaatacttt gtcgttgacc cgatggctga gtacaacatg
     5641 ccccagtata tcctgcgtga attcaaagtc acagatgccc gggatgggca gtcaaggaca
     5701 atccgacagt tccagtttac agactggcca gagcaaggag tacccaagac gggggaaggc
     5761 ttcatcgact tcatcgggca ggtgcacaag acaaaggagc agtttggaca ggatgggccc
     5821 atcacagtac actgcagtgc tggtgtgggc cgcacagggg tgtttatcac cctgagcatt
     5881 gtcctggagc gcatgcggta cgagggcgtg gttgacatgt tccagaccgt gaagaccctc
     5941 cgcacacagc gccctgcaat ggtgcagaca gaggaccaat accagctgtg ctaccgtgcg
     6001 gccctggaat acctcggcag ctttgatcac tatgcaacgt aactactgct cccctctcct
     6061 ccgccgctcc cctgaggggc tccggagggg acccagctcc tctgagccat accgaccatc
     6121 gtccagccct cctgcacgga tgctgttgcc ggcagagcac agcccactgg gatcacagca
     6181 tttcgggaac attgccacac cagtcagaga gcccagaaca cctgggcaag taggcggact
     6241 ggcagcctgg ctctgggccc tcgtccaccg ggcccaagtg gagccctgct tcaagctctc
     6301 tgttcagctc cgcgattctc atgcttctca tggggtggga aagggggcag agccccccac
     6361 gttttataca tttaggcggg gtagactgcg gggtcctagc ctcttcctcc gactttcctt
     6421 ttgcaggtct ttcactacag attgggctgc tgtgggagtt gggacttact tgttttcctt
     6481 tttgagttca cgttggatcc ttgtacaact tctgcggaag gacacagtac acgctttcct
     6541 tcctcgagca gagctagggc cctacctgag caagtcggct gtggcccggg aggcagctga
     6601 gactcctgct gtcctccagc ctttcagagg agatcctatt ccagccaaat gcagggaaac
     6661 actttatttt gttttaggtt ttgtttttcc ttgagagcct ttttttaggc cccacagaca
     6721 gtggtgggcg gggaggcgat aggaaacaca tccccagtgt gcatttaaca ttcatagcct
     6781 acaaccacag acgtgtctgg ggggagcctg gcaaggcgtt cctcgtcacc atcgtgtttg
     6841 caaaggttca aaaaagcaaa aattaaaaaa aaaaaacata aaaatatttt tttttaaaaa
     6901 aaagaaataa agattcatcc cctggcctct ccttctgctc cgaagtggga ggcaactcaa
     6961 tgtgcctggg gctcgttgtg ggcccacaga gtcttgctgt catccccagc ggtgcagtgt
     7021 ggcaggtgtt tgtaagctgt gggttctggc cacctcggta actgaatggc acaggtgagg
     7081 gcctgtgcca cgccccacac acctcagggc caagcggggg cgtggccggc ccttcaggtc
     7141 taggccagtg ggcctggtag cacatgtctg tcctcagcgg gacagatgct ttctctcctg
     7201 gtttgcagct gtcttcaaat cccccatgac tcgcccttcc cactccttca agtcgccctc
     7261 acaaaccaat gtggcaagac tactggactt gtatccatgg tactctactc agtcctctta
     7321 tctcagcttg ctgaggggca gggagagggt ctcttcctct gggcagcact atctaggtag
     7381 taagtggggg cgggaaaggg tgcatagctg ttttagccga aggactcgat gtggacgtcc
     7441 tcagatatag ctaggctaag cggagatcga cggtccgggg ttggtggtgt tggatgagac
     7501 attcattttt accttgtgga cgctagtgct gtagagttca ctgttgtaca cagtctgttt
     7561 tctatttgtt aaggaaaact acagcatcat tgcatacttc ttgatggtaa taaatttgaa
     7621 taatcagatt tcttaca
//
LOCUS       NM_001436908            4148 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus thymocyte selection-associated high mobility
            group box (Tox), transcript variant 1, mRNA.
ACCESSION   NM_001436908 XM_039110215
VERSION     NM_001436908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4148)
  AUTHORS   Artegiani,B., de Jesus Domingues,A.M., Bragado Alonso,S.,
            Brandl,E., Massalini,S., Dahl,A. and Calegari,F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
REFERENCE   2  (bases 1 to 4148)
  AUTHORS   Yun,S., Lee,S.H., Yoon,S.R., Kim,M.S., Piao,Z.H., Myung,P.K.,
            Kim,T.D., Jung,H. and Choi,I.
  TITLE     TOX regulates the differentiation of human natural killer cells
            from hematopoietic stem cells in vitro
  JOURNAL   Immunol Lett 136 (1), 29-36 (2011)
   PUBMED   21126536
REFERENCE   3  (bases 1 to 4148)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   4  (bases 1 to 4148)
  AUTHORS   Aliahmad,P. and Kaye,J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
REFERENCE   5  (bases 1 to 4148)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   6  (bases 1 to 4148)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110215.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.20913.1,
                                           SRR26643288.21413.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               JAXUCZ010000005.1  24967582-24968025   c
            445-510             JAXUCZ010000005.1  24822463-24822528   c
            511-753             JAXUCZ010000005.1  24803320-24803562   c
            754-1035            JAXUCZ010000005.1  24722995-24723276   c
            1036-1266           JAXUCZ010000005.1  24706495-24706725   c
            1267-1347           JAXUCZ010000005.1  24694150-24694230   c
            1348-1731           JAXUCZ010000005.1  24681968-24682351   c
            1732-1883           JAXUCZ010000005.1  24674144-24674295   c
            1884-4148           JAXUCZ010000005.1  24671564-24673828   c
FEATURES             Location/Qualifiers
     source          1..4148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..4148
                     /gene="Tox"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
     exon            1..444
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    328..330
                     /gene="Tox"
                     /note="upstream in-frame stop codon"
     CDS             343..1920
                     /gene="Tox"
                     /note="thymocyte selection-associated HMG box"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_001423837.1"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
                     /translation="MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPVSQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMQEIGNAEGAQYSSHPQLAAMRP
                     RGQPTDLRQQASMMQHGQLTTINQSQLSAQLGLNMGGTNVPHNSPSPPGSKSATPSPS
                     SSVHEDECEDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYNDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQPLVQQPLASQLPM
                     QVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWST
                     DYCSSGGMQRDKALYLT"
     misc_feature    1126..1335
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    1126..1335
                     /gene="Tox"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; Region: HMG-box_TOX-like;
                     cd21995"
                     /db_xref="CDD:438811"
     misc_feature    order(1126..1131,1135..1149,1156..1161,1180..1182,
                     1216..1221,1228..1230,1237..1242,1261..1263,1273..1275,
                     1282..1284,1294..1296,1303..1305)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     misc_feature    order(1126..1131,1135..1149,1156..1161,1180..1182,
                     1216..1221,1228..1230,1237..1242,1261..1263,1273..1275,
                     1282..1284,1294..1296,1303..1305)
                     /gene="Tox"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438811"
     exon            445..510
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            511..753
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1035
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1266
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1347
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1731
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1883
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..4148
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttacct gcccggcggc gggccgagag cgccggggcc gagcggacca ggcaggctgc
       61 gcgctcggcg tggacgggtg cgcgccgcgg cttagggggg gagagttgag cacttttcca
      121 ccctctgtgc gtttttttct ctctctctct ctcttttctc tctctctctt ttcctcctct
      181 tcttaaacaa accacaaacg gatgtgaggg aaggaaggtg tttcttttac tcctgagccc
      241 agacgcctct ctctgttccg tctaagcttt tttttttctt ctgagcactt tttttttttt
      301 tcaaaaagga aaagaaaagg agttgcttga tgtgagagtg aaatggacgt aagattttat
      361 ccacctccag cccagcccgc tgctgcgccc gccgctccct gtctgggacc ttctccctgc
      421 ctggacccct actattgcaa caagtttgac ggtgagaaca tgtatatgag catgacagag
      481 ccgagccagg actatgtgcc agtcagccag tcctaccctg gcccaagtct ggaaagtgaa
      541 gactttaaca tcccacccat tactcctccc tcactccctg accactctct ggtgcacctg
      601 aatgaggtgg agtccggtta ccactctctg tgtcacccca tgaaccacaa tggcctgctt
      661 ccattccatc cacaaaacat ggacctgcca gagatcaccg tgtccaacat gctgggccag
      721 gatggcacac tgctctccaa ttccatctct gtgatgcaag agattggaaa tgctgaagga
      781 gctcagtaca gttcccatcc tcagctggca gccatgaggc cgagaggcca gcctacagac
      841 ctcagacagc aggcaagcat gatgcagcac ggccagctga ccaccatcaa ccagtcacag
      901 ctgagcgcac agttgggctt gaacatggga ggaaccaacg tcccacacaa ctccccttct
      961 ccacctggga gcaagtctgc aaccccttcg ccttccagct cggtgcatga ggatgagtgt
     1021 gaggatacct ccaagatcaa tggaggagag aagcggcctg cctctgatat gggaaaaaaa
     1081 ccaaaaactc ctaaaaagaa gaagaagaag gatcctaatg agccccagaa gcctgtgtct
     1141 gcctatgctt tgttctttcg tgatacccag gctgccatca agggccaaaa tccaaatgct
     1201 acttttggtg aagtctctaa gattgtggca tccatgtggg atggcctagg agaagagcag
     1261 aaacaggtct acaagaagaa aactgaggct gcaaaaaagg aatacctgaa gcagctagca
     1321 gcatacagag ccagccttgt atccaagagc tacaatgacc ctgtggatgt taagacatct
     1381 cagccacccc agctggtcaa ctccaagccg tcagtgttcc atgggcccag ccaggcccac
     1441 tcagctctgt acctaagttc tcactatcac caacaaccag gaatgactcc tcagctcacc
     1501 gccatgcatc cgagcctccc cagaaacata gcacctaagc ccaataacca aatgccagtg
     1561 actgtctcca tagccaacat ggctgtgtcc ccaccaccgc ccctccaaat cagcccacct
     1621 cttcatcagc atctcagcat gcagcagcat cagccacttg tgcagcagcc tcttgcgagt
     1681 cagctcccca tgcaggtcca gaccgcctta cactcgccca ccatgcagca aggatttact
     1741 ctccaacccg actatcagac tattatcaac cctacatcta cagccgcaca agttgtcacc
     1801 caagcgatgg agtacgtgcg ttctgggtgc agaaatcctc ccccacagcc ggtggactgg
     1861 agtaccgact actgcagtag tgggggcatg cagagggaca aagcgctgta cctcacctga
     1921 aaatctcaac acctctcctt tccactgagg aattcaggga aaccttttca ccacggattg
     1981 ctttggccgc tcaaagcagt tcttcatttt attagaaaat acaagttgct aagcacttag
     2041 gaccatgtga gcttgtgggt cacccacgct ggaagaaata gtcatgcttc tttattattt
     2101 ttttaatctt ttatggacat tgtccctctt ccctgaagga agtatgggcc attcagattt
     2161 ctgttggttt tgctgtgaag tgctgccgct ctagtaactg ccttagcaac ggtagatgtc
     2221 tggggtaaaa cggtcctggg ttttccattg gttttcataa tgggtgttta tatgaaacta
     2281 ctaaagactt tttaaatggc ttgatgtagc agtcatagca agtttgtaaa tagcatatat
     2341 gttacactct cctagagtat aaaatgtgaa tgtttttgta gctaaattgt aatttgaaac
     2401 tggctcaccc cagtttgttg atttcagagg ggttaaattg gcaaacattc atatttttac
     2461 ttcattttta aaaagaaaaa aaacaactga ctgatagttc tatattttca aaagacttga
     2521 aaactattcc caaatcattt taatttaaaa acaaattggc tttgtcttat tgatcagaca
     2581 aaaggaagct ctcgtgtgga gggaagcgca aacacattta ttttgtattg caggaaaaaa
     2641 attctttttt gtatcacttt tgtgtaatgg ttagtaagcg tcatctaagt ccttttatgt
     2701 ataaaactgc caaatgctcg cctggtatct tagctgcaga aacaggtcaa acagcgctaa
     2761 gtgatcaccg ttacctgtgg ctctgtgtta ctgttccctc atccgtgtct gtatttaatc
     2821 gttttcttct cttttttttt taatgaaact tgtttcgctt atttatgaaa taataaatat
     2881 aggtgtttgt aagtaaattt gttagtattt gaaagaggtt ttgttgatgc tttaattttt
     2941 gctggcaaaa aagaaaaaaa atccatgctt ggtgtgaata tttagttttt acagtgacat
     3001 gaataaaacc aaaactgctt ttcatttagt agcaaaatag agtgacgaat ctgtattttt
     3061 gcatatcttt tgttgacata aatgaaaaac aattctactt agccatcttc ttctcttgaa
     3121 caatacaaca gaaaattgcc ctggagatct cacacttgcc aagcctaagc aaacaccagt
     3181 gcatcccgtt cctaaaaaga tacgaagagc tatttttcac ttctccattc caaaacattt
     3241 aaccaccacc accacaccac acacacccgc taaaaaccaa attcaagttg agtcactcaa
     3301 aattcctcaa gccacatgct tctcatagca tgcagaaaac atttaagaat tgaccaaggg
     3361 ttcaggaaga ggtcaaagaa ggatatcatg tctaggatca atctagaaat gaaggactag
     3421 taaccagatc agctatagaa ataggaaaaa catggaaacc ggaagcagtt gctagaaact
     3481 gtgaaatctg ctgtccctct cccctctact ctcttcttcc tcttctatgc atcctgagtc
     3541 cctgtaagag atttgcctga aggtgtttgc atagttctga tagcagaagg gaagggtgag
     3601 gaaatgtttc ccttccacgg gcttctgtca cgtaaattca tctggctgga catgaagaga
     3661 atgattgttt tgcggaatga aataacctca acaatttaaa tacaaatata tcatgtaatc
     3721 cagtcaaaat taaaaagaca aaagtcttgc ttgctttgga ttggtttttc agacactgtg
     3781 cgagttgaat cacttggcat gtaatgacta ataaataatg cacattcagt gttattatta
     3841 aaatggccgg ggtcgagagc tcaaattttc ctgtcttgat actgtataag aattcgtgtg
     3901 attaacttcc cagtttattg tttggctgtt tagtatttta gaaatatacc agcattatta
     3961 attaactaat gccttttatt attgtattat gataaaatat tactttctcc tacattaagt
     4021 ccaaactgag aagagtccga ccagctaaga taagaggtgt atcaggagat tgtctgcagc
     4081 ttttcctggc aggcgaaaag aaaaaaatac atcaaatgtg aaataaatta tcaattaaac
     4141 tctcactg
//
LOCUS       NM_001436850            9238 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 9B (putative) (Trmt9b),
            transcript variant 1, mRNA.
ACCESSION   NM_001436850 XM_006253222
VERSION     NM_001436850.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9238)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006253222.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.71730.1,
                                           SRR26360186.2699504.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000016.1  62495163-62495479   c
            318-542             JAXUCZ010000016.1  62494663-62494887   c
            543-731             JAXUCZ010000016.1  62470460-62470648   c
            732-886             JAXUCZ010000016.1  62460835-62460989   c
            887-1060            JAXUCZ010000016.1  62453208-62453381   c
            1061-9238           JAXUCZ010000016.1  62439625-62447802   c
FEATURES             Location/Qualifiers
     source          1..9238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..9238
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
     exon            1..317
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            318..542
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            543..731
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    724..726
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="upstream in-frame stop codon"
     exon            732..886
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     CDS             733..2073
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /codon_start=1
                     /product="probable tRNA methyltransferase 9B"
                     /protein_id="NP_001423779.1"
                     /db_xref="GeneID:306504"
                     /db_xref="RGD:1304810"
                     /translation="MDPEAVQLEKQHVHKVYESTAPYFSDLQNKAWPRVRQFLQDQKP
                     GSLIADIGCGTGKYLKVNSQVHTLGCDYCGPLVEIARNRGCEVMVCDNLNLPFRDQGF
                     DAIISIGVIHHFSTKQRRIRAIKEMARVLAPGGQLMIYVWAMEQKNRHFEKQDVLVPW
                     NRALCSRLLSESHQSWGHSCEHPTSQGYQGPGSACSCAVCFKGRCDSKRSHSMDYGPA
                     VARTCCEAISKEGQQENGLYSNFGKSFRSWFFSRSLDESTLRKQIERVRPMKIEGWAN
                     STVSHQPSRYPSVDLHAQEPFSTKRPNLDEVFVDASSQRHVGCLGVPSTSDNFIGHKG
                     GESRRKEGGNFLDTTDTGNSVAARNGGDRSARKILRRVSAFDSTDSTSEDPSFVEGQQ
                     DGPDSKAFMRYYHVFREGELSSLLQECVSELQVLSSGNDHGNWCIIAEKKRSWD"
     misc_feature    820..1161
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     misc_feature    820..1161
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; Region:
                     UbiE; COG2226"
                     /db_xref="CDD:441828"
     exon            887..1060
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..9238
                     /gene="Trmt9b"
                     /gene_synonym="RGD1304810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcagga tcaaaaggga agagttaggc ttagggtcac gtgggtgtca ccacaggtac
       61 tgagctgcgc ttggggcccc gccaggtgta cccgcccaga ggcgtctccc gcttaggacc
      121 cttcacccca ccggacactg gagtagagcg aggtgagaga caggaaggtc atcctgattc
      181 cagcctcagg cacgtccggg cgcggcgatc gcaggggaca gacagagcgg ccacaccgct
      241 tgggctctgc cgcgcgcccg cgccgcaccg agccgactcc gaggcgcccc gggcttgcgg
      301 tcagagcctg gggagaggcc gacccatgga agttgcatcc tggacagtcc gggctgcgac
      361 gctgaagagc accgagccag tgctcggccg agcctcccgc ccggatcccg ggcaaagacc
      421 gcccaaaacc tgctgttgac cttcgtctgc actgctcaat ggtgacccga gtcttcgctg
      481 tcctagttgc agccatttgg catccccaag actgccagag cacccgggat ctgcaaacct
      541 ggggcttgga ttctcttcag agactcatac tgagtggtgg atcttgtgaa gggctcacta
      601 actcaattcc tgctcctttc atgtgtgtta tatactgaga gccctgagaa ggaactgttc
      661 ctccctgagg aaggaaactg ccgtgattta ccaaaaccag aaataatcca catgatcaca
      721 aaatgagtca ggatggatcc cgaagccgtg cagctggaga agcagcacgt gcacaaggtc
      781 tatgagagca ccgcccccta cttcagtgac cttcaaaaca aagcttggcc ccgcgtccgc
      841 cagttcctgc aggaccagaa gccaggcagc ctcatcgctg acattggttg tggaactgga
      901 aagtatctta aagtgaatag ccaagtacat actctgggct gtgactactg tggccctctg
      961 gtagagattg cccggaatag agggtgtgaa gtcatggtat gtgacaacct taatctcccc
     1021 tttagggacc agggcttcga tgctatcatc tccataggag tcatacatca tttctctaca
     1081 aaacagagaa gaatcagagc aataaaggaa atggccaggg tcttagctcc cggaggccag
     1141 ctgatgattt acgtctgggc aatggaacag aagaaccgac actttgagaa acaggatgtg
     1201 cttgtgccat ggaacagggc actctgttcc cggctgctgt cagaatccca ccagtcgtgg
     1261 gggcattcgt gtgagcatcc cacgagccaa ggctaccagg gccctggctc cgcgtgcagc
     1321 tgtgcagtgt gttttaaggg cagatgtgat tccaagcggt cgcacagcat ggactacggg
     1381 cctgcggtgg ccagaacctg ctgcgaagct atttcgaagg aaggacagca agagaatgga
     1441 ttatatagca attttggaaa atcctttcgc tcctggtttt tttccaggtc tttggatgaa
     1501 tcaaccctga ggaagcaaat tgaaagggtc aggccgatga aaatcgaggg ctgggccaac
     1561 agcaccgtgt cccaccagcc ttcccgatac cccagcgtag acttgcatgc ccaggagccg
     1621 ttttcaacaa aaagaccgaa cttagatgag gtgttcgtag acgcatcttc tcaaagacac
     1681 gtgggctgcc tgggagtacc cagcacttca gacaacttca ttggacacaa gggaggagag
     1741 agtaggagga aggagggggg caattttctg gacaccactg ataccgggaa cagtgtggct
     1801 gcaagaaatg gcggtgatcg ttctgccaga aaaatattaa ggagggtttc tgcattcgac
     1861 tccacggact ccacctcaga agacccaagc tttgtggaag ggcaacagga tggcccagat
     1921 tccaaagcct tcatgcgtta ctaccacgtg ttccgggaag gtgagctgtc cagcctgctg
     1981 caggagtgtg tgtctgagct gcaggttctg agctccggca atgaccatgg taactggtgc
     2041 atcatcgcag agaaaaagag gagctgggat taactacatc gctcaaggca gaggctacag
     2101 cccatcatct gctcaatggg gctgatgtgg acaccagaat cggcacccta gttcattgct
     2161 ttcaaatcca ggtatgagtc ggaccgtgag cactgtgccc tcatcctccg aactgttgag
     2221 taagcatgaa ggctggcatg tcctgcctct gctgcgggat ctgcctgctg aagtttcaat
     2281 caaaggatcc gaggaagcag tagaaagtaa acttaagtac agacttgatc ttattcctcc
     2341 cagagatgaa attattacga tacgtgtacg tcaagtgtca gtattatctt ttggttttta
     2401 aataatcccc tgttaaatat accttttaaa agtagtaatt tttaaaaata aattatgttg
     2461 gttctcaggt agttacttag atccctgtgg aaggtaacag agacacctgt gctgttgctg
     2521 ggcatgtgtt taaggttcgc tgtggtggta tctcgtttcc ggacttcgtt gctaactaca
     2581 tcaacccttc cagtatagcc cagaccctct aaattacatg caaacgccct tagggatgat
     2641 cgatgttact aatactgtct tcagcattgc tctgaggctt ttacaaggcg ctattagcag
     2701 agggttggtg ttaaagcaga cagtttgcat gcggcggaat cagcaaacat ccatggcacc
     2761 attgacagaa gaaaaagtaa acaaaggatt gttagcgtgc agagtgcttt acaggggtag
     2821 cagatggtat gtcccctggt cacattttcc ccaaaggcat taggagcata aatatctaac
     2881 tgaggttgtc ccaaagttat ccagagtttt caactaggaa gtgcatatct gagttagcta
     2941 agagtctaat tggagccgtt ttactttggc tgtgaggaca gatctggaaa tcgtcatgta
     3001 tttagtggac acattactgg gattcgctgc tgcatgccat ggcatttatt cccttgaagg
     3061 tgaccacatt agatcattgt atcagtgacc tggacggaat caaagcttgg tcacaagttg
     3121 aatttctggt attctagagt gcaatgatta gactgggtat ggtacaaatc aatactcttt
     3181 tatttttaaa gacttaatca tgagtctgat taattctatg ttgtggatcc caataacaat
     3241 tatgacagaa ttcaagactg aactcaggag aaacaaaaat aagttggcca aggaatatgg
     3301 ttccagataa ttcgttaaca agcaggaaat caaatagtca ttgtactttc tggaccgata
     3361 taatgatgga gattggatta aaatccaatc ttcactttct ttttttctcc cactacaaag
     3421 ttaacaaaaa ttgcaatgga tcatatttat ttggtgttta ccctcttcag agattttgct
     3481 ggactgtatg aaaatgaagc tacttttgaa aaacacaact caaaaggtgc tttgaaaatg
     3541 caaagtatat cttgtaaact ttagaatgaa tcagataatt cctgaggttc tttcaagtcc
     3601 aagttccgtc tcttcaaccc tgctgtggaa gtggcatgtg tgtcttgtac tttccagcgt
     3661 acactttgta cagggaggca tgaaaatagg cataggggta aagcatagat taaaatttac
     3721 tgtgccttcc acttcttcaa atgaagatat taaactccat gtacggtggc ttcctgggag
     3781 aagcggtgac tctgaactag tcagcagtaa tgacctcttt attatggttt cccgcttctc
     3841 tgaggtctgt gtcactttga cttggctttc gctgctggat gtctaagcct gacatcaccc
     3901 tggttggaat gtgctaccta aaggtcattc tatggaactc agttcatcag gctgtgacag
     3961 gatggtttac cagctgatat gtctgaacaa gctcacaaaa taaacacaca ccccatcttg
     4021 tattaaaaag ccttcggaat ggttattggg atagagagag atttttccta caatgataga
     4081 gctgtgagcg ctaataacac caaccttgtt aagtgcaaga attccatgca tccagatgtt
     4141 ttattgtcta tttagcaaaa tctgtggctg gtaagcttcc tgggatcctt gtgcaaaagc
     4201 agtcttccat tcagtgtttg ccttttgatg ataaaaagcc attgagaact agtgtaaata
     4261 tcttaaccgt ttaaaaggtt gttctccttt gggattgtcc tcagaaggaa acacaagtcc
     4321 taaatgtata taaatggaga cggtgtatgt ccgtcggcct taatcagctt gtgggtggat
     4381 ctcactgatc tgtctaaagt gatggaaaaa accttctcca cgttaagaca aaatggtgtt
     4441 tttctaattc cctcctggca tccacacatg agtcccactg tctgacggag ggaaagttca
     4501 gggaagtcat tagataattg ttagaggttg gactagcagt acctccccgg cttgtgtggg
     4561 gcactttgtg gaaacagaca agtgatttgg ggggaaaagt gattgacttg aacgaaagat
     4621 gcaatcaaag taacagtttc ctgggaggcg agtgattggc aagcttctct ggttattggg
     4681 ttttagtgtt catgtggggg tgggggggtg ttctttgttg gcagagagac gaagtatgac
     4741 cagagtgctg cagtgcttca ggctggctat gcacacacac tggctgccat gctgattgat
     4801 cctttcctct aaccttgctg tacgccatcc ccatactgtc tgtcactcat tttgcctacc
     4861 cctcatcctg attctggagg ccaaagactc ccatgtgctc aactgacctt catttgagtc
     4921 agcaaaaaaa caaaaaaaca aaaaacaaaa caaaaaaaaa aacaaaaaac aaaacaaaaa
     4981 aacaaaaaaa aactgaaggt gattcaggtg ggaaaggatc caaatgtaaa tcaggatttc
     5041 aaaagtactt gactactatt ggccatggaa caaatgaatg ctggtagatc tttcaaatac
     5101 gtgggctccc aggagaacag gaaatgggac cctagttgta ctcattatgt gagtgaatgc
     5161 cttagaaaca aggtgtgagg gcctactggg tggcttgctg gtttagagtg ctgtcctgca
     5221 gatggcctga aagtggctcc tagcaccatg tcagacagct cacaagtgcc tcttcaggat
     5281 gccgagggta cctgcactct cgtgtgcaca gacctaagca tacatgcaca gacacagaca
     5341 cagacacaca cacacacaca cacacacaca cacacacaca tacacagaca catgcacaca
     5401 cagacagaca cagacacaca cacagacaca tacacagaca cacacacaca caggcacaca
     5461 cacaggcaca cacacagaca cacacacagg cacaaacaca cagacagaca gacacacaga
     5521 cagacagaca gacacacaga cacacacaca cacacacaca cacacacacc aaaaataaat
     5581 attttttaag aacaggctat gcatgcccag cctgaatgag gaaactgaag taactgttca
     5641 ctacttggtt cttcagagcc tgttgtgatg gtgcagaaaa aagtaagcca agtctcactt
     5701 ttcctgaaca gaagaaggga tgggtaacaa tagcagctga ctaatattta tcacgttatg
     5761 tgtgtaaccc ccaatagctg tctcaaacaa atataatccc caatttgcag ataagaaagg
     5821 cagaaaagga aaaagataat aatgcgctaa gatatcagaa tctacacaag cagtaaacat
     5881 cacccattta gtgaaaaaca gctaagattc agtcctagac tgtctggatc cggtctaagt
     5941 tcataaccac ctgccaggtc ccagactcta tgccaagtaa gcaacagagt gtgcaaggtt
     6001 aagtgtgact gtcccctgca caaatgcatt aagcaggtta ggaaaagact acacctctct
     6061 ttccccttcg tgctgtcttt tcagtatttc acatgtactt gtctgtgcat ctgtccctga
     6121 ggaggtcgga agatagcttg caagagttag ttcattcctc taagatctat atgtcccctg
     6181 agccctcttg ccagccctgt tttgtttctt tgtttgtttt ataattctat ttctatttga
     6241 ctagaattta aaaagctctt gatcacaggg cactctgatc actttctaca attcccaaac
     6301 cctccaaaaa gcatagctct gttttcctgt tttaatcaat gaagaactta gggactaaca
     6361 caggtattcc tttttttttt tttttttttg ttcagaaccg tttggtgtct ctagatacaa
     6421 gtgatgaaag ccaggacata tctggggtat tgggttatac acaatatgaa gacttaatga
     6481 ccaaaaattc aagtgtcctg ctggaacaca ttttgttttt gctgtatgtc tgtgatcaca
     6541 tgacattgtt agttttgtaa aacacaatat tcaaaccccc ttcctggggt gggggaagag
     6601 aggatcacga tgcatataat taacatggag aatgcctgtc tgacacactt agatttcatt
     6661 taactgaggc taccctgggc caattgacac agcctccagc acaagtgctc agtaaacgta
     6721 tttcagaaaa ggatgtgtcc tgtagggaca gatatgaagt cattcggaag gcatgcaggc
     6781 ccctagtaac caactcaagt tctgtttcag actcgtttcc tacaattgca cctgttttct
     6841 gttctgcaat cagctatttt aaacaatgat ttcattaaaa ctacataata gcaagtcatt
     6901 atcccatccc ttgaagggat ctaatatatt cagactagaa atgctgttaa ttataaactt
     6961 tcctcaaaga cagacgcacc agcaggctca ttccatcaat agacacagga atgctagcac
     7021 tcatctggca aagggagccc tgggaaagtg agaggatcag aagccccact tgatatttca
     7081 agtcctctgg tcccagcctt gggtcagaaa ccagaactct gttttgacac catggactcc
     7141 atccccaagt ctccagttat attcaaaact ggggtaagaa cttaaaaaaa aaaaaaagct
     7201 cttagcaacc aagaactgag atcaaagcac aaatagcatt ccaagggagg gaagactgga
     7261 aacccaagag aatgatgaaa caaaacgcag gctatgaagt gtacagtttt tcatcttgtt
     7321 tgaaacaggg tctcatgtat cctaaactgg ccctgaactt gctgtgtact tgaggataac
     7381 cttaacttct gatcctcctg gtttctatga gacaggagat ccagtgcaag gcctgatgca
     7441 taataggcag gaactcaacc cattgagcct catctccagc cccaagctgt gtaacgcatt
     7501 attcaccctg agtcccacag tgtaccccag tagtagaagt gtttcattgg agtgttaccc
     7561 tactgtctgc ccctccacta tgacggttct ccttcgatgg attataaaca gacaatagat
     7621 cacttcatgt tgctacgtaa tctggctaat ccaatggacc acttgtgaga actgatatcc
     7681 gatcagatac tcaactggca aatacacgct ttgtctcctt tcgactagag ctgggaaaaa
     7741 aataaagcag actctagtat aattaagtgt taattcaacc acatgaaaac acctgatttt
     7801 ctccttagtt atttgtcgaa ggctcctatc tcatggggga aagtgagtgc cttagtttcg
     7861 gttttattgc tgtgaccatg gcaactcttg taaatgtaaa catttgatga gggctggctt
     7921 acagtttcaa aggtccatta tcatcatagc aggaagcatg gcagcaggca tggtgctgga
     7981 agagccaaga gttctacatc ttggtctgca ggtagcagaa ggagactggc ctccacaggc
     8041 agtcaggagg aggctctgat tccacactgg atgtagtttg agcttttata tgagaccgga
     8101 aagcctgccc ccacagtgac acacttcctt caacaaggcc acacctccta atagtatccc
     8161 tccctgtggg ccaagcattc aaacacatga atctatgtca gtcaaaccta ttccaaccag
     8221 cacggtgagt catggtaatt cctttatggc aagtgtagcc agatatcaaa agtccttaga
     8281 cgaagtatcc acaaatttgc attcatacag gagaaaaact atgaaacaca agcttcctct
     8341 tatgcactaa tcctaaaact tctccttaga tggtgtatgg taagaactca aaattctcct
     8401 gtttgtttat ccaggacatt ggcaatattt aagacccaca tgtaagatct aagacattct
     8461 gaatatgtat gtgaacatgt cccatgttct tcagatgctc ttcaatatgt atgtatgtaa
     8521 tatatatgtg catacgcata tttgtagact cccagtgttt gttgtcatta ctgaccagga
     8581 aaagagttct cttgtgtgct tgcagaagac attaaattag caattaccat aggaacgcat
     8641 ctcattgaat tggcctttat tgttgcttca ggagcattta agaagactgc tagatgcttt
     8701 catgccttcc ctggtgttga catatgtatt tgtgtcaaaa gtgtgaagct tttttcccct
     8761 taaatatagt tattttaatc tccccccccc agggggaact agcaatagat ctagagcaca
     8821 aattgatgta agacatcttg actcttacaa taacctaaag atatttattt acgtgaacca
     8881 acagtggcca ggatcttttt gtaacagcta tttaaaatag cataatttgt atgcctgtga
     8941 tatgtagttg attatttatg tgtttgtgta ttctttaata atagtctcaa acaaacagga
     9001 ttggagtttt cttcctcccg aatgtgtcag ggcaggtgct gttaggctcg ctcacatgat
     9061 gcttgttaca cttcaatgaa actcaaccag tctgtacttg aattctgttc ccgttgtctg
     9121 gaagctgggt tagccgtcta atgatacagc atcttttatg ggttgataga aaggatatta
     9181 tctacttttt aaaagacata ttttaagact aataaaagac gtagtagacc accccaaa
//
LOCUS       NM_001436913            7567 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), transcript variant 1, mRNA.
ACCESSION   NM_001436913 XM_006237901
VERSION     NM_001436913.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7567)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 7567)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 7567)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 7567)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 7567)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 7567)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006237901.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2210231.1,
                                           SRR26360194.2413634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               JAXUCZ010000005.1  31984712-31985081
            371-540             JAXUCZ010000005.1  32013271-32013440
            541-678             JAXUCZ010000005.1  32078977-32079114
            679-920             JAXUCZ010000005.1  32081132-32081373
            921-1010            JAXUCZ010000005.1  32085402-32085491
            1011-1192           JAXUCZ010000005.1  32089757-32089938
            1193-1443           JAXUCZ010000005.1  32102023-32102273
            1444-1529           JAXUCZ010000005.1  32107640-32107725
            1530-1731           JAXUCZ010000005.1  32108284-32108485
            1732-1800           JAXUCZ010000005.1  32117199-32117267
            1801-1991           JAXUCZ010000005.1  32122846-32123036
            1992-7567           JAXUCZ010000005.1  32131303-32136878
FEATURES             Location/Qualifiers
     source          1..7567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7567
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..370
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..540
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    432..434
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="upstream in-frame stop codon"
     CDS             453..2267
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="isoform a is encoded by transcript variant 1;
                     CBFA2T1 identified gene homolog; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 1; cyclin
                     D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein; protein
                     CBFA2T1; core-binding factor, runt domain, alpha subunit
                     2, translocated to, 1; runt-related transcription factor
                     1; translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform a"
                     /protein_id="NP_001423842.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MISIKRNTWRALSVVIGDCRKKANFEYCQDRTEKHSTMPDSPVD
                     VKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPS
                     SSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTL
                     TIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLL
                     LDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRY
                     SPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHG
                     TRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYW
                     IRRYSDAEDLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAE
                     EAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQ
                     EDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAV
                     SSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR"
     misc_feature    816..1085
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    816..1085
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR1 homology to TAF; Region: TAFH; pfam07531"
                     /db_xref="CDD:462195"
     misc_feature    1461..1661
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1461..1661
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="NHR2 domain like; Region: NHR2; pfam08788"
                     /db_xref="CDD:430219"
     misc_feature    1779..>1943
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1779..>1943
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="Archaeal/vacuolar-type H+-ATPase subunit E/Vma4
                     [Energy production and conversion]; Region: NtpE; COG1390"
                     /db_xref="CDD:441000"
     misc_feature    1995..2105
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1995..2105
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     exon            541..678
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..920
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1010
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1192
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1443
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1529
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1731
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1800
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1991
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..7567
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcacatt tgtctgccac agcagcaaca acagagagga gcggagggag ggagcgaggc
       61 gggaggaggg ggagctgagc tcggcgcgcg ccgggctccg cgtcgcagcc tgcgtctgcc
      121 tggcgtccgc caccccgggc tcctcgccct gcatctcgct gtgcgaagcg gctgtccgca
      181 atcctcaaga ctaggcggtc ggtctctggg cgagcgcgag tgggcgagtg gccacggaca
      241 ttctggcatc gcgagggagg cggcgccgcg ccctggtcct ctggccccgc cggccagcac
      301 cgaccgcagg aagttttatt tgcagctggg agcccgcggc ggatggtggg actcttcagc
      361 cttgtgcagt aaaagattga tctgtgggct ggtgaactta tctgggtccc agtccgagca
      421 gcagaggaag ttagcacagc gcttgctgga gaatgatatc tatcaaaaga aacacttgga
      481 gagcactgag tgtagtgata ggtgactgcc ggaaaaaggc gaactttgaa tattgtcaag
      541 atcgtaccga gaagcactcc acgatgccag actcacctgt ggatgtgaag acgcagtcta
      601 ggctgactcc cccagcaatg ccgcctcctc cgaccactca aggagccccg agaaccagtt
      661 cgtttacgcc aacgacatta acgaatggca ccagccattc acccacggcc ttgaatggcg
      721 ccccctcacc gcctaatggc tttagcaacg ggccttcctc ttcctcttcc tcttctctgg
      781 ctaatcaaca gctgccccca gcctgtggtg ctagacaact gagcaagctg aagcgatttc
      841 ttactaccct gcagcagttt ggcaatgaca tttcaccaga gattggagaa agagttcgca
      901 ctcttgtact aggactggtg aactctactt tgacaattga agaatttcat tccaaacttc
      961 aagaagctac taacttccca ctgagacctt ttgtcatccc gtttttgaag gccaacctgc
     1021 ccctgctaca gcgtgaactc ctccactgcg caaggctagc caaacagaac cctgcccagt
     1081 acctcgctca gcacgaacag ctgcttctgg atgccagcac cacctcccct gtcgactcct
     1141 cagagctgct tctcgatgtg aacgaaaacg ggaagaggcg aactccagac agaaccaaag
     1201 aaaatggctt tgacagagag cctttgcact cagaacatcc aagcaagcga ccatgcacta
     1261 ttagcccagg ccagcggtac agtccaaata atggcttatc ctaccagcca aatggcctgc
     1321 ctcaccccac cccacctcca cctcagcatt accgtttgga tgatatggcc attgcccacc
     1381 actacaggga ctcctatcga caccccagcc acagggacct cagggacaga aatagaccta
     1441 tggggttaca tggcacacgt caagaagaaa tgattgacca cagactaaca gacagagaat
     1501 gggcagaaga gtggaagcat ctcgatcatc tgttaaactg cataatggac atggtagaga
     1561 agacgaggcg atccctcact gtactaagac gatgtcagga agcagaccgg gaagaactga
     1621 attactggat ccggaggtac agtgatgctg aggacttgaa aaagggcggc agcggtagca
     1681 gcagccactc caggcaacag agccccgtca atccggaccc agtcgcatta gatgcacatc
     1741 gggaattcct tcacaggcct gcgtctggat acgtgccaga ggagatctgg aagaaagctg
     1801 aggaggctgt gaatgaggtg aagcgacagg caatgacgga gctgcagaaa gccgtgtctg
     1861 aagccgagag gaaagcccat gacatgatca ccacagagcg agccaaaatg gaacgcacgg
     1921 tggctgaagc caagcggcag gccgcagagg atgctctggc agtcatcaac cagcaggaag
     1981 actccagtga gagttgctgg aactgtggcc ggaaagcaag tgagacctgc agcggctgta
     2041 acacggcccg atactgtggc tctttttgcc agcataaaga ctgggagaag catcaccaca
     2101 tctgtggaca gaccctgcag gccccacagc agggagaaac gcctgctgtc agctcctcag
     2161 tcacgcccag cagtggggct gggagcccaa tggacacacc accagcagcc actccgaggt
     2221 ctaccacccc cggaaccccc tccaccatag agacgacgcc tcgctagacc taaactcaga
     2281 ctgtcagagg aaagacacca caaccaacac gaaagcaatt cctcatcctc agatgctcaa
     2341 agtccctttt ctgtttgttt gtttatagat gaactatcta tcttatttca gtacttcggc
     2401 aagagagaac ctaactgtat ctttgaggcg atagtaaaac acagaggcca gtaacgggtc
     2461 gtaatgactt actgtggaaa acaaagatat cttttcttta gagaactgaa aagagaggaa
     2521 agaatataac gtgaaatgct agatttgacc tcctccctgt tattttcaag tagctgggat
     2581 tttaaactag atgacctcat taaccaatgc tttaccaaac agcaaaccaa gagattgcta
     2641 attgctgttg aaagcaaaaa tgctaatatt aaaagtcaca gtgttcttta tatacaataa
     2701 tggaaagaaa aaaaaaaaag aggcaattcc tcaagggcac gagcgttgga tacagcagta
     2761 gacattttaa caagaagatg aatggcgtct gtgggttgct aactgaactt tgaagaccgg
     2821 ctgcaaaacg cacagatgtg cagcagattg gaaggagaca cagatgttcg ttttttttcc
     2881 cccgtttctg aaaaagaaat aataatatcc aggtcaacag aatgaaaaat gaaagatgat
     2941 ttccagtggg gtgtatgact acagcagcaa gaaaaaaaaa attgccataa tacaaaggct
     3001 cctttttata tcacacacac acacacacac acacacacac acacacacac acacacacac
     3061 actcactctc tctctccctc tctctctctc ttaagagact cagcctgcag ttaattagca
     3121 ttctggcagc ttccaagtca gccagctgcc ctaaataacc cttcaacgtt tcttcacttt
     3181 tgcaaggttc cacagagtaa gacattgaat ctattccagc ttattcattt tatatcgaaa
     3241 aaccaatttt tttaaaaaaa aaaatggcgg cttcagctcc agcccctttc caaaattttt
     3301 caaccccacc ctgtttgggt ttttaattaa aatctagtag ttctcttggt attaaaacac
     3361 ttctgtcctg tgaggttttc ccaatggtgt ttttcttgta aatgtgttgg acaaatgtga
     3421 agatgcgttg tagttgatcc atatgcccac atttagtctc tttattccta gttggtgaga
     3481 gaaaccagta tctttctatg ctgcttttat atctgtatgt attagtgata tttctctagt
     3541 agttaaaaaa aaaaaatgaa aagaaaagaa aaaaaaaaac cacacttttt ttggttgtcc
     3601 tcaagaaaag aagaaaagaa aagaaaagaa aaagctatct tttggagctg ctaactcact
     3661 ctcttatagg atttttttcc tggaaaccag catgcttcat ggaatgctag cacatggatg
     3721 tttttaagag ggatgtacat aaatgtattt tgcactgtca caatgactcc ctaggcatgc
     3781 tttttttttt tcaaaccaac tttttaaata tgctagagcc atttcaccaa ttttagctgt
     3841 agcatagagt agtagtggaa tttttctttt atcctttttt ttatgaaaaa aaaaattatt
     3901 agggactttt taaaaaaaaa taaaataaga tatcctactt taaaaaaaaa ggacagtgca
     3961 tgcatattgc tgtaaggttg tttaagtatt tctaatttta caaaaaaaaa atgaaaaaaa
     4021 aaatcattag ctctccaaat gctgaggtgt agacggacag ctttagccct gctgagtgcc
     4081 aggttataca gtattcttac aaaagggaag tcagccaaag actgatctga tggaccaaaa
     4141 tcggaatttt tgaaaagcac cagtaatcct ttccaaatga tcagcaggtt aaacatgttc
     4201 agtgtgactc cattaaccct tcgttgtcca gggtccagac cagaactact tgttagtttt
     4261 gaaacacatt attagcccag gatgtggttg tgtgctttaa gagtcggcag tgctgcaggc
     4321 tgtgtagaca accaaagttg aaaggctggg aagacacttt tccacataca catacaccag
     4381 gcatttcttt acaaaattga gtacaatcca ttagcttgtg ggagggggga gcgggtaatg
     4441 tagcccttgg atacagtttt aagtggttgt gttttaagtt ttctgcatag atgcaatcct
     4501 cacgggattg cttcatgtct cgcaaatcta aggtttcctt aaaccatttc ccctgtattt
     4561 tcatatacca gtcggttttg attttgtccc ggtagtgttg tgttcttttc tcttgtcgtc
     4621 gtcgtcgttg ttttcaatgg ccttttagtt taggaagttc tgatgagcga atcaatgcat
     4681 ctatctatct gcatgttgga agtccatctg ccagcacacc cgctaaggca aagagaagcg
     4741 cataaccagg ctgcgaatgg gttctatttt accatggtgc tcccagaatc ctttgacctc
     4801 attctgcttt ctagtctgct tgtgacactg gacagtcctt tcttagagct attatatgtt
     4861 ctaggctacg aagggttaaa taatcccaaa aaaaataaca aaaaaaaatg aggtatgtca
     4921 taccctcgcg tctcgatctc aagaagctgt gatgtatgtg gaacagcact gttattctga
     4981 acactagtgt gtaaaataag gattagtaca gtacgtctca ttcctttttt aattcagggc
     5041 accctgagtg aaaaccaata caaaaaaaaa aaaaaatccc taactctgag ctctgtctct
     5101 aattcctctt cctccttccc ctcttcctcc tcctcttcct ctactcctgt tttgctacat
     5161 tctcctcagt ggcaaaaagt ttcactctac ctctgacagc atgtatattg caccagtcgc
     5221 taacgaaaac tggtctagtc aaaccaaatg ggcacaaaag aaccaggata ccaaaagtta
     5281 agctcataca gctgcgaacc atatcacttc ttggtaacaa tgcagacctc ataaacctaa
     5341 aaaaaaagag aaagaaaaga aaacttttgt tactttcctt ttttgcttgt cacttatata
     5401 caggctatgt gagagtattc atttgtaggt attacacatt aaaaaaaaaa agctatcttc
     5461 attggataga actgaatggt ggtcgctgat aggaataggg cgtcctctat ctcttatctc
     5521 tgtctctttt ctctttctct ttctctgtca tgagactgtg tgtgacaggg ctacctgtct
     5581 ttttaatttg ttttctgaac tttttttttt taatgtgtag gtgcatgtct tggggattta
     5641 aaaatttcaa ggctggttta cttatgcaaa gcatgcctat gtctggaata cttagggaaa
     5701 gaaagtgact ccatgttgtc cgaattcctc aagggacaga aaaacaaatt ggagactgtt
     5761 gaaatgcaga tttgaagtaa ttttattttt aattattttg ggttctgcga cattattgtg
     5821 aaaaattaaa gtcgttgtgc aatacttaat tcagacacgt gccacaagtt aacggtagac
     5881 taacactggg gggcgggggc taggcatcac gcttttgtct gcatactctt gagcttttaa
     5941 gtctactatg tctgaactgt ggtttcttgt ttatcctttt ttgttttttc cttagttgga
     6001 ctgtaatgta tggtctgtca acctgtgaat ctttaaagta tgattcaggt attgttgtac
     6061 tctttaccgt gtaataaaaa tgcttaaaaa aaaaagtcag tagtccgtct cccttatctt
     6121 tactgtgtgc ccgccaaggc taccactcag gaacctcatt cttgaagggc agttcttcat
     6181 ggagcatgcc cagagtctag tcagctacag agtatgtctc taacgtgtta attcgcccac
     6241 gagtgatgag ggagaaggag agaacacaga ggacatttct gaggtcatag tagtccaata
     6301 tagaaggata ctccaagtcc tccataagaa aggatagctt atgctagggg tcaccgtctc
     6361 cagaaaggtc caattgccat ctttttaaac tctggcttgc agcatgtttc tttcattctc
     6421 agctgcagga tgtacccact aaggcagatc tcttcctcca tctgtcctgg atcctcaccg
     6481 cctttaatta gaagttgcca gcatgttcac acttggtttt gtacatttgt aaatacacag
     6541 tatgttgtgt ccatcttgtt tctgagaccc atgttgtcca tttaacacgc accagtatat
     6601 tttttttcat gcactagcta taaaaaataa cttagacttt ggagaaccta ttggtcatct
     6661 accatagaaa ctcagtcaat tttcacgtac tttacacaac acatttttta atgactgtat
     6721 atactgcatt gtagcagaat ttctgatttg cttggaagat tcccgctatg gcctaaaact
     6781 agcttaaagg gatcaagtga aatgcaagaa ctgaatctgg agagacagag aagtcacata
     6841 gacgctgtcg agtgggagga taacctaggg ccttctcttc agtttccttt gtacgccagc
     6901 taggccccta tgcctgtcct gaggcctggc ttctccaaat gatgttgaga aatgcagcct
     6961 attttacaga gtgaggaagg gagcggggaa gggagggagg gaggagggag aaagagagag
     7021 agagagagag agagagagag agagagttta aaagcatagc tagtgcgtat cttattccta
     7081 caaaataaac aggctgagta tttagttttg tagttaattt ttcccctcac tccaaagcct
     7141 gaccagcgtg gctcaacttg cttttcttat ttgtacagat acattttctt tttcttttca
     7201 aagtggaaca gaccagaaac cagaagacat ggaggacata actgagatgc cttgaagtag
     7261 cccctttata agctgtcctt gaaaaacagc tctgtgacct atttgtatga ctggattgct
     7321 agacaaatga gtaatgagtt tagtttagag gaagaatgtg aacaaaatca gcttctgggt
     7381 ggtaagcacc attttttaaa agaatgtaat tgatgtattt gataatataa aaatgatgtt
     7441 tgccatgaaa gaacactaag ttatttcccc agattggaag gggaagaaat gatcaaagag
     7501 gtgcttttct gtatgggtat ttatatcttt atttcaaggt gaatgaataa agttgtactt
     7561 gcctaaa
//
LOCUS       NM_001107234            1880 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus ring finger protein 215 (Rnf215), transcript
            variant 1, mRNA.
ACCESSION   NM_001107234 XM_001065855 XM_223565
VERSION     NM_001107234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001107234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.564712.1,
                                           SRR22582424.110341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000014.1  83230282-83230636
            356-499             JAXUCZ010000014.1  83230878-83231021
            500-571             JAXUCZ010000014.1  83231620-83231691
            572-657             JAXUCZ010000014.1  83231772-83231857
            658-814             JAXUCZ010000014.1  83232255-83232411
            815-934             JAXUCZ010000014.1  83234692-83234811
            935-1078            JAXUCZ010000014.1  83234888-83235031
            1079-1181           JAXUCZ010000014.1  83235186-83235288
            1182-1880           JAXUCZ010000014.1  83235375-83236073
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1880
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="ring finger protein 215"
                     /db_xref="GeneID:305478"
                     /db_xref="RGD:1310738"
     exon            1..355
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1204
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="RING finger protein 215 isoform 1 precursor"
                     /protein_id="NP_001100704.1"
                     /db_xref="GeneID:305478"
                     /db_xref="RGD:1310738"
                     /translation="MGPADRPALRSPSSPPPPPSPPSPLLLLLPLLPLWLGLMGPGAA
                     ADGSEPEARAGRGGARAVRVDVKLPRQDALVLEGVRIGSEASPEPLLGGRLLLMDVVD
                     AEQEIPADGWIAVAYVGKEQVAQFHQENQGSSQKAYPKALVQQMRRALFLGASALLLL
                     ILNHSVVRELDISQLLLRPVIVLHYSSNVTKLLEALLQRTQATAEISSGESLSANIEW
                     KLTLWTTCGLSKDGYGGWQDLVCLGGAQAQEQKPLQQLWNAILLVVMLLCTGLVVQAQ
                     RQASRQSQQEPGGQEDLFKRRVVRRLASLKTRRCRLSRAAHSLPEPGAETCAVCLDYF
                     CNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGNHYSDD"
     sig_peptide     65..199
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    1037..1186
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 215 (RNF215) and similar proteins; Region:
                     RING-H2_RNF215; cd16670"
                     /db_xref="CDD:438332"
     misc_feature    1037..1186
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 215 (RNF215) and similar proteins; Region:
                     RING-H2_RNF215; cd16670"
                     /db_xref="CDD:438332"
     exon            356..499
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            500..571
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            572..657
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            658..814
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            815..934
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1078
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1181
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1880
                     /gene="Rnf215"
                     /gene_synonym="RGD1310738"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcggttct cctggccccc ccgcggacct tagactacgg cctcaccacc tctccggtcc
       61 ggtcatgggc ccggccgatc gcccggcact gaggtcgcca tcttcgccgc cccctccccc
      121 atcgccgccg tcgccgctgc tgctactgtt gcccctgctg cctttgtggc tgggcctgat
      181 gggtcccgga gccgcggcgg acggcagcga gccggaggcc cgggctgggc ggggcggagc
      241 ccgcgcagtg cgggtggatg tgaagctgcc gcggcaggac gccctggttt tggagggtgt
      301 caggatcggt tccgaagcga gtccggaacc tctactgggc ggccgcctgc tgctgatgga
      361 tgtcgtggat gctgagcaag agatacccgc agatggctgg attgcagtgg catatgtggg
      421 caaagagcag gtcgcccagt tccaccagga gaatcaaggc agtagccaga aggcatatcc
      481 caaggctctg gtccagcaga tgcgccgagc ccttttcctg ggagcctctg ccctgcttct
      541 cctcatccta aaccacagtg tagtccgaga gttggacata tcccagctcc tgctcaggcc
      601 agtgattgtt ctccattact cttcaaatgt caccaagctg ttggaagctc ttctgcagag
      661 gacccaggct actgctgaga tcagcagtgg agagtccctt tcagccaaca tcgagtggaa
      721 gctgacattg tggaccacct gtggtctctc caaggatggc tacggtggct ggcaggactt
      781 ggtgtgcctg ggaggtgctc aagcccagga gcagaagccc ctgcagcagc tatggaatgc
      841 catcttgctt gtggtcatgc tcttgtgcac aggccttgtg gttcaggccc aacggcaggc
      901 atcaagacag agccagcagg agcctggagg ccaggaggat ttgttcaaac gccgtgtggt
      961 tcggagacta gcatccctca agacccggcg gtgccggctg agcagggcag cacacagcct
     1021 tccagagcct ggcgctgaga cttgcgctgt ctgtcttgat tacttctgta acaagcagtg
     1081 gctccgggta ctgccctgta agcatgagtt ccaccgagac tgcgtagacc cctggctgat
     1141 gctacaacag acctgcccac tgtgcaagtt caatgtcctg gggaaccact actcagatga
     1201 ctaactcccc agtggagagt ctgcacatcg ggatggaccc ttcccagcct acactacagg
     1261 agagtgggat gggcagacca gctagccctg tgggcaaagg aaaggttccc accatgccca
     1321 tgatggatag gagggactcg cacctccagg ctgaagacac agagccagga cccagcaggc
     1381 aaggagaaat cattagagcc cttctctgca aacctggggt attgtgtctg tcctcatagg
     1441 cagctcccac aactctggga aagaaaatat ggccactaca tctgtccaca gcactctgga
     1501 gcttcggtgt tgaattttat gctatttatt gagggagaat atgtgtggcc atgggaccca
     1561 ctggcatgac cgtgtctttc gggccatggc ctaatcaaat caaagatgac gttaaagtga
     1621 gcctgctcca ctccctgctg cccgtccagc tggattcctc cagtctgact gggatcagag
     1681 gccttagaaa ccatctagtg ctgtatttct tggttggcct aaatgttact gcaggatact
     1741 tgaggccaca gaatacatgt ggtgcatctg ccaagggcat cattacaaga aaaaaacaaa
     1801 aacacaaaaa caaatgtttg ggtagggaag ttttaatagt aaaataaaca tggagtatat
     1861 tttaacatat aagacataaa
//
LOCUS       NM_001436948            4594 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436948
VERSION     NM_001436948.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Young,G.P., Symonds,E.L., Nielsen,H.J., Ferm,L., Christensen,I.J.,
            Dekker,E., van der Vlugt,M., Mallant-Hent,R.C., Boulter,N., Yu,B.,
            Chan,M., Tevz,G., LaPointe,L.C. and Pedersen,S.K.
  TITLE     Evaluation of a panel of tumor-specific differentially-methylated
            DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of
            colorectal cancer
  JOURNAL   Clin Epigenetics 13 (1), 14 (2021)
   PUBMED   33478584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Sharma,B., Shah,R., Jamwal,R.S., Verma,S., Bhat,A., Bhat,G.R.,
            Bakshi,D., Singh,S., Angurana,S., Bhat,A., Vaishnavi,S. and
            Kumar,R.
  TITLE     Evaluation of newly identified Ikaros family zinc finger 1 loci in
            colorectal cancer
  JOURNAL   J Cancer Res Ther 17 (1), 46-50 (2021)
   PUBMED   33723131
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Musher,B.L., Melson,J.E., Amato,G., Chan,D., Hill,M., Khan,I.,
            Kochuparambil,S.T., Lyons,S.E., Orsini,J. Jr., Pedersen,S.K.,
            Robb,B., Saltzman,J., Silinsky,J., Gaur,S., Tuck,M.K.,
            LaPointe,L.C. and Young,G.P.
  TITLE     Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1
            to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC)
  JOURNAL   Cancer Epidemiol Biomarkers Prev 29 (12), 2702-2709 (2020)
   PUBMED   32958500
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Zhao,W., Chen,T.B. and Wang,H.
  TITLE     Ikaros is heterogeneously expressed in lung adenocarcinoma and is
            involved in its progression
  JOURNAL   J Int Med Res 48 (8), 300060520945860 (2020)
   PUBMED   32787735
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Symonds,E.L., Pedersen,S.K., Murray,D., Byrne,S.E., Roy,A.,
            Karapetis,C., Hollington,P., Rabbitt,P., Jones,F.S., LaPointe,L.,
            Segelov,E. and Young,G.P.
  TITLE     Circulating epigenetic biomarkers for detection of recurrent
            colorectal cancer
  JOURNAL   Cancer 126 (7), 1460-1469 (2020)
   PUBMED   31909823
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Boggs,S.S., Trevisan,M., Patrene,K. and Geogopoulos,K.
  TITLE     Lack of natural killer cell precursors in fetal liver of Ikaros
            knockout mutant mice
  JOURNAL   Nat Immun 16 (4), 137-145 (1998)
   PUBMED   10366784
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Molnar,A. and Georgopoulos,K.
  TITLE     The Ikaros gene encodes a family of functionally diverse zinc
            finger DNA-binding proteins
  JOURNAL   Mol Cell Biol 14 (12), 8292-8303 (1994)
   PUBMED   7969165
REFERENCE   10 (bases 1 to 4594)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.44182.1,
                                           SRR26643292.52728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000014.1  90469387-90469437
            52-105              JAXUCZ010000014.1  90483799-90483852
            106-222             JAXUCZ010000014.1  90491020-90491136
            223-480             JAXUCZ010000014.1  90531794-90532051
            481-648             JAXUCZ010000014.1  90537327-90537494
            649-771             JAXUCZ010000014.1  90541436-90541558
            772-906             JAXUCZ010000014.1  90544514-90544648
            907-4594            JAXUCZ010000014.1  90552834-90556521
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4594
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
     exon            1..51
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            52..105
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1610
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DNA-binding protein Ikaros"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros isoform 2"
                     /protein_id="NP_001423877.1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
                     /translation="MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQ
                     NSKSDRGMASNVKVETQSDEENGRACEMNGECAEDLRMLDASGEKMNGSHRDQGSTAL
                     SGVGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLR
                     HIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHK
                     ERCHNYLESMGLPGMYPVIKEETNHSEMAEDLCKIGAERSLVLDRLASNVAKRKSSMP
                     QKFLGDKCLSDMPYDSANYEKDEMMTSHVMDQAINNAINYLGAESLRPLVQTPPGSSE
                     VVPVISSMYQLHKPPSDGPPRSNHSAQDSAVENLLLLSKAKSVSSEREASPSNSCQDS
                     TDTESNAEEQRSGLIYLTNHITPHARNGLALKEEQRAYEVLRAASENSQDAFRVVSTS
                     GEQLKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGE
                     HRYHLS"
     misc_feature    414..476
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    414..476
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(429..431,435..437,441..443,447..452,459..464,
                     471..473,513..515,519..521,531..536,543..548,555..557,
                     597..599,603..605,609..611,615..620,627..632,639..641)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(429..431,435..437,441..443,447..452,459..464,
                     471..473,513..515,519..521,531..536,543..548,555..557,
                     597..599,603..605,609..611,615..620,627..632,639..641)
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    453..527
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    453..527
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    486..>1325
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    486..>1325
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    498..560
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    498..560
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    534..611
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    534..611
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    582..644
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    582..644
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    666..731
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    666..731
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            106..222
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            223..480
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            481..648
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            649..771
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            772..906
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            907..4594
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggccc ggcgcgggca agcgggctgc agccgccggc ggcgccagca gataatctga
       61 agacaatgga tgtcgatgag ggtcaagaca tgtcccaagt ttcaggaaag gagagccctc
      121 cagtcagtga cactccggat gaaggggatg aacccatgcc tgtccccgag gacctgtcca
      181 cctctggagc acagcagaac tccaagagtg atcgaggcat ggccagtaat gttaaagtag
      241 agactcagag tgatgaagag aatgggcgtg cctgtgaaat gaatggggaa tgtgcagagg
      301 atttacgaat gcttgatgcc tcaggagaga aaatgaatgg ctcccacagg gaccaaggca
      361 gcacggcttt gtcaggagtt ggaggcattc gacttcctaa cggaaaacta aagtgtgata
      421 tctgtgggat cgtttgcatc gggcccaatg tgctcatggt tcacaaaaga agtcatactg
      481 gtgaacggcc tttccagtgc aaccagtgtg gggcctcctt tacccagaaa ggcaacctac
      541 tgcggcacat caagctgcac tcgggcgaga agcccttcaa atgccatctc tgcaactatg
      601 cctgccgccg gagggacgcc ctcaccggcc acctaaggac gcactccgtt ggtaagcctc
      661 acaaatgtgg atattgtggc cggagctata aacagcgaag ctctttagaa gaacataaag
      721 agcgatgcca caactacttg gaaagcatgg gcctcccggg catgtaccca gtcattaagg
      781 aagaaactaa ccacagcgaa atggcagagg acctgtgcaa gataggagca gagaggtccc
      841 ttgttctgga caggctggcc agcaacgtcg ccaaacgtaa gagctctatg cctcagaaat
      901 ttcttggaga caagtgcctg tcagacatgc cctatgacag tgccaactat gagaaggatg
      961 agatgatgac atcccacgtg atggaccagg ccatcaacaa tgccattaac tacctggggg
     1021 ctgagtccct gcgcccgttg gtgcagacac cccctggtag ctccgaggtg gtgccggtca
     1081 tcagttccat gtaccagctg cacaagcccc cctcagacgg cccaccacgg tccaaccact
     1141 cagcacagga cagcgccgtg gagaacttgc tgctgctgtc caaggccaag tccgtgtcat
     1201 cagagcggga ggcctcccca agcaacagct gccaagactc cacggataca gagagcaacg
     1261 cggaggaaca gcgcagcggt ctcatctacc taaccaacca catcactccg catgcgcgca
     1321 acgggctggc tctcaaggag gagcagcgcg cctacgaggt gctgagggca gcctcagaga
     1381 actcgcagga cgccttccgt gtggtcagca cgagtggtga gcagctgaag gtgtacaagt
     1441 gcgaacactg ccgcgtgctc ttcctggatc atgtcatgta caccatccac atgggctgcc
     1501 atggcttccg ggatcccttt gagtgtaaca tgtgtggtta tcacagccag gacaggtacg
     1561 agttctcttc ccacatcaca cggggggagc atcgctacca cctgagctaa acccagccag
     1621 gccccactga agcacaaaga tagctgggca tgcctctttc ccagcagctg gacccacggc
     1681 ggacaatgtt gggagtggat ttgcaggcag catttgttct tttacgttgg ttgtttgaga
     1741 tttgatttgc gtttagaaga caagttttta atgttagaga caggattcca ttgcatcagg
     1801 aacgttcaga acacccatcc ttctagacgg ttttgttgac tgctagctga gatttccctg
     1861 gtatgtggct tcctaacgct ctccctaccc gccccacccc caaaacagag cccgaatctt
     1921 cagagaaatt aattaaacaa ttacccaagt aggagcaagg tggatttttc cctaagcaga
     1981 gtttatacca caaagattct ccaagtcctc caaaacagca cagggacatc agcctgtgca
     2041 gagaccaggg ccgaaggctg aacttagaaa gctactatta ggccatgtat tgcacggcaa
     2101 tgcggtgtcg gaacaagatg tttgaggtgc tgaagggaag ggattggaga gccatgtggc
     2161 tcttcttcat ttgcctgatc acactcagcc tcctgagggc ttgatgccca gtaagatgag
     2221 ctcactgctc ttgtgatcgt ttttctatca gttccgtgcc tttaatggcc ccaaagctca
     2281 tcactgcatt ttagaaccca atcctgaaat tgagaccttg ttttaaactt ctgatactgt
     2341 aaaacttctt ggaagccaaa gctttcttcc aagccccatc cccagttatc ttggttcctg
     2401 ttcttccctg ggctgatagt tccgggacct gctattccat gaaaacaagc acaacccacc
     2461 cttcacttca actgaacccc tgttctgatt atagctatgg actcggctgt cttgataaat
     2521 gtctttccct gctctggatg tatgttattt tctttgaaaa cctgtgacac cattatccag
     2581 aatgaccatt tttagatgga agaaatatgt gagcccagca tctcagtggc taaaacacaa
     2641 aatatccata ctttcaaaca aaatttttaa atattccaaa gctctcttct atagacaccc
     2701 agtagcacat gttttcacat aaataggata cgggaccatg caacctttat caagtagagg
     2761 tattagaatg gtgtgaggtt tggaggcaga gtgtgaccag tacaggttcc cagagaacct
     2821 gtatagccag accaagacag agatgtcacg ctgaagacaa gtcaattagc tagaggttct
     2881 cagcagaaag gcctctctca agagtcagta ttagggttgc taccctctat cagctcaaca
     2941 gaaataattg taaatgttta cagcactgtc ttcacagaaa cttgttgctg taaaattata
     3001 aaaaatgctg tcttctcccc tgcactaggt caagcactgc agcgccccaa gatagctggt
     3061 agatacttca tctcagtcag caaagcgtct cacccgctct tctccatccc atatcacaca
     3121 gacaatggct actctctgag cctggcaaca atctctctgc ccatctagtt gtcaaggcag
     3181 gttgccacca tgccagacat acacatccca attccatggt ggcccagtgt ctccaccacc
     3241 acaaactctc tttaacttaa atcgccctat gaaagaacac acaacacaat gacctctgat
     3301 ccaattgatg agatataatt tgctcatcta gacacaaaaa accctgtaca catccacccc
     3361 ttaagaatat tcataacaac ctgtaaatgt gcagagagga atcttaacat ccgcctccat
     3421 gttctctcct ctgcttctcc tgcctcctcc agtctcctcc tctctctaaa atatttctcc
     3481 tgcccatcct tccttctcat ccaatgacag gcctccttct ctcttgtacc tgccttcacc
     3541 tgaatgacat cctacagaaa ctttctgagg tgattccaca gaactggagg agagattgtc
     3601 tataacagct tttgagctaa aatgacgttc ttagtcgcag ctctcctgac atacagggca
     3661 tgatcatcac tggtgggggt cgttctgtga aatgcagctt gcttagtact acccctggtc
     3721 actccccact agatgccagg agcaccctag ctgataccca aaactgtctt cccgggtgct
     3781 ccatgggcgg aaaactactg atctaaactc taaatgagtg caaagtacgg aagttttcca
     3841 aaaagtaaaa agcacttgaa gcctttcccg gtcagcagcc tcaagctgta ctgtgtcttt
     3901 gcagtgctga tgaattctat aaatcagcat tggcaaatac acttcagata cttctgagtt
     3961 caagtgaagg gacagagttc acaaaggtat ccctcttaag tctgtgtttc tttgtttcca
     4021 gaacaacatg gcatttcgaa agcgaaagta aaattacaaa tataacgacg tacagtgaat
     4081 aaagggagag aatttgagga actagagctg tggacagttt ttgttccata tgcaattata
     4141 ggactggcct tacccaaatt cacatattcc aggtgacaac cttccaagcc tacaatttgc
     4201 tggcagcttt tactcactct tgttcttagc aatgagagcc attaagtatg gtccaaggaa
     4261 gatggctcca aaccccaccg ccacccccgc ccccacccct gacactggta atcaaaggtt
     4321 aaagcggaat tgtaaatagt ggcttcagga gctgtttttt agaatgcttt gccctttcct
     4381 ctcactgcct tttttagcca atataaatgt ctatttgcac accttttgtt gtggttttat
     4441 attgtaacag catttttttg aaactattgt atttaagata aggtttcata ttatgcccac
     4501 aagtaattaa attatgtttg aaggtggcta tattctgtat caaaagttga taatgttttt
     4561 ctttagctgg taaagtaggg ttttgcatga gctc
//
LOCUS       NM_001436899            2553 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus caspase 3 (Casp3), transcript variant 1, mRNA.
ACCESSION   NM_001436899 XM_006253130
VERSION     NM_001436899.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Niedermeyer,S., Yun,X., Trujillo,M., Jiang,H., Andrade,M.R.,
            Kolb,T.M., Suresh,K., Damarla,M. and Shimoda,L.A.
  TITLE     A novel interaction between aquaporin 1 and caspase-3 in pulmonary
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L638-L645 (2024)
   PUBMED   38375595
  REMARK    GeneRIF: A novel interaction between aquaporin 1 and caspase-3 in
            pulmonary arterial smooth muscle cells.
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Holota,R., Decmanova,V., Alexovic Matiasova,A., Kosuth,J.,
            Slovinska,L., Pacut,L., Tomori,Z., Daxnerova,Z. and Sevc,J.
  TITLE     Cleaved caspase-3 is present in the majority of glial cells in the
            intact rat spinal cord during postnatal life
  JOURNAL   Histochem Cell Biol 161 (3), 269-286 (2024)
   PUBMED   37938347
  REMARK    GeneRIF: Cleaved caspase-3 is present in the majority of glial
            cells in the intact rat spinal cord during postnatal life.
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Galichanin,K. and Yu,Z.
  TITLE     Expression of active caspase 3 in the rat lens after in vivo
            exposure to subthreshold dose of UVR-B
  JOURNAL   BMC Ophthalmol 24 (1), 29 (2024)
   PUBMED   38254051
  REMARK    GeneRIF: Expression of active caspase 3 in the rat lens after in
            vivo exposure to subthreshold dose of UVR-B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Li,C., Zhang,H., Mo,J., Zuo,J. and Ye,L.
  TITLE     Caspase-3/GSDME dependent pyroptosis contributes to offspring lung
            injury induced by gestational PFOS exposure via PERK/ATF4 signaling
  JOURNAL   Arch Toxicol 98 (1), 207-221 (2024)
   PUBMED   37955688
  REMARK    GeneRIF: Caspase-3/GSDME dependent pyroptosis contributes to
            offspring lung injury induced by gestational PFOS exposure via
            PERK/ATF4 signaling.
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Vito,P., Ghayur,T. and D'Adamio,L.
  TITLE     Generation of anti-apoptotic presenilin-2 polypeptides by
            alternative transcription, proteolysis, and caspase-3 cleavage
  JOURNAL   J Biol Chem 272 (45), 28315-28320 (1997)
   PUBMED   9353287
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Ni,B., Wu,X., Du,Y., Su,Y., Hamilton-Byrd,E., Rockey,P.K.,
            Rosteck,P. Jr., Poirier,G.G. and Paul,S.M.
  TITLE     Cloning and expression of a rat brain interleukin-1beta-converting
            enzyme (ICE)-related protease (IRP) and its possible role in
            apoptosis of cultured cerebellar granule neurons
  JOURNAL   J Neurosci 17 (5), 1561-1569 (1997)
   PUBMED   9030616
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Juan,T.S., McNiece,I.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Fletcher,F.A.
  TITLE     Molecular characterization of mouse and rat CPP32 beta gene
            encoding a cysteine protease resembling interleukin-1 beta
            converting enzyme and CED-3
  JOURNAL   Oncogene 13 (4), 749-755 (1996)
   PUBMED   8761296
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Liu,X., Kim,C.N., Yang,J., Jemmerson,R. and Wang,X.
  TITLE     Induction of apoptotic program in cell-free extracts: requirement
            for dATP and cytochrome c
  JOURNAL   Cell 86 (1), 147-157 (1996)
   PUBMED   8689682
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006253130.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.50606.1,
                                           SRR26643291.38239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000016.1  52413687-52413752   c
            67-134              JAXUCZ010000016.1  52405106-52405173   c
            135-259             JAXUCZ010000016.1  52402552-52402676   c
            260-388             JAXUCZ010000016.1  52400663-52400791   c
            389-564             JAXUCZ010000016.1  52399499-52399674   c
            565-685             JAXUCZ010000016.1  52398718-52398838   c
            686-2553            JAXUCZ010000016.1  52395472-52397339   c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2553
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="caspase 3"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
     exon            1..66
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            67..134
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..915
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /EC_number="3.4.22.56"
                     /note="IRP; SCA-1; CASP-3; CPP-32; apopain; cysteine
                     protease CPP32; SREBP cleavage activity 1; protein Yama;
                     Caspase 3, apoptosis related cysteine protease (ICE-like
                     cysteine protease); CPP32beta; cysteine protease p32-beta"
                     /codon_start=1
                     /product="caspase-3"
                     /protein_id="NP_001423828.1"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
                     /translation="MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEM
                     GLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDS
                     VSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFII
                     QACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQS
                     LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFY
                     H"
     misc_feature    82..84
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    112..114
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P70677; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); acetylation site"
     misc_feature    157..159
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42574; propagated from
                     UniProtKB/Swiss-Prot (P55213.2); phosphorylation site"
     mat_peptide     166..606
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p17.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004591"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     misc_feature    190..912
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    190..912
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Region: CASc; smart00115"
                     /db_xref="CDD:214521"
     misc_feature    order(271..273,445..447,562..564,583..585,691..708,
                     718..723)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(271..273,445..447,562..564,583..585,691..708,
                     718..723)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(442..444,568..570)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(442..444,568..570)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(586..588,646..651,670..672,679..681,688..690,
                     757..759,781..783,799..801,859..861,874..879,883..885,
                     892..897)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(586..588,646..651,670..672,679..681,688..690,
                     757..759,781..783,799..801,859..861,874..879,883..885,
                     892..897)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(589..591,643..645)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(589..591,643..645)
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     mat_peptide     607..912
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /product="Caspase-3 subunit p12.
                     /evidence=ECO:0000250|UniProtKB:P42574.
                     /id=PRO_0000004592"
                     /note="propagated from UniProtKB/Swiss-Prot (P55213.2)"
     exon            135..259
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            260..388
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            389..564
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            565..685
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2553
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgcagtgt tggtgttggt gggatcaaag cttagtgtcc tgaggtgcgg agcttggaac
       61 ggtacgcgaa gaaaagtgac catggacaac aacgaaacct ccgtggattc aaaatccatt
      121 aataattttg aaacaaagac tatccatgga agcaagtcga tggactctgg aatatatctg
      181 gacagcagtt acaaaatgga ttaccctgaa atgggcttgt gtataataat taataataag
      241 aacttccata aaagcactgg aatgtcagct cgcaatggta ccgatgtcga tgcagctaac
      301 ctcagagaga cattcatggc cctgaaatac gaagtcagga ataaaaatga ccttactcgt
      361 gaagaaatta tggaattgat ggatagtgtt tctaaggaag atcacagcaa aaggagcagt
      421 tttgtgtgtg tgattctaag tcatggagat gaaggagtaa tttttggaac gaacggacct
      481 gtggacctga aaaaactaac tagtttcttc agaggcgact actgccggag tctgactgga
      541 aagccgaaac tcttcatcat tcaggcctgc cgaggtacag agctggactg cggtattgag
      601 acagacagtg gaactgacga tgatatggca tgccagaaga taccagtgga ggccgacttc
      661 ctgtatgctt actctaccgc acccggttac tattcctgga gaaattcaag ggacgggtca
      721 tggttcatcc agtcactttg cgccatgctg aaactgtacg cgcacaagct ggaattcatg
      781 cacatcctca ctcgtgttaa ccggaaggtg gccacggaat ttgagtcctt ctccctggac
      841 gccactttcc atgcaaagaa acagatcccg tgtattgtgt caatgctcac aaaagaactg
      901 tacttttatc actaaaggaa tgactgggag tggggtaggg gcatgtttct gttttggttt
      961 ttttttttgg tttttgtttt ttgttttttt ttttttattt gaatgccaaa tgagaaaact
     1021 gtcagggaga cttttttttt cccctctcat ttaaatcaaa tccgatgttc caggtcgtca
     1081 ttgaacaata ccactgcctg caatgcagcc acaatacaat acctcagctt tgatatcagg
     1141 tagttgaaat gaaatttaat taggaacaaa taaatgtcaa taatggtaca accatcatag
     1201 aagaaattgg aaagtcacac tttggtaatt agagagattt ggtgccacta tgaatttgaa
     1261 attacgaagc agtgatgatc ttataccccc tcctcacatc tagaatgtca ctttagtttt
     1321 cgttaagcat aggaacgata atgtcaagtg gtatgtctta gaacttgaat ccacgagcag
     1381 agtcaaaggc tggttttgga actgatctgt ggaaatgaag agttggagca ctgtagcaca
     1441 cattatagct actggttttg tgacagttga ccaggtcaca tatttattat ttaagacaaa
     1501 agtcgtgttt tattattgga acaaaaataa ctttatatga gaggaaaacc atgtgtgaac
     1561 ttggttggct tgttgaaggc taccatcctt cagtggtgga catgacgaca gggtgctacg
     1621 atccaccagc atttgtttct tacttattct tatgcaaatc agcctaattt tacagaccag
     1681 caaaatatct aaagagcgat tatgcagcag cctcaaattg ttgactatta gaatggaata
     1741 aaggaattct acaggaacag accataatac cagctgtcag tcagagcgta aggaaaggag
     1801 aggtggcatc tcctgtgatt ggagagaaga tggtttgagc cggagcagag ccatgggcac
     1861 gtcttcagaa aaggcctgct agttggaccc accttgtgag cactggtctg tgtggatgat
     1921 gtccaagtta ccacatgaga ctgaaccaga tcagaagctc ctgcaaaaag gctttcccag
     1981 agtgctgagc atctcaagaa agttcactgg actccatgta cagagtctgt agcatgctga
     2041 cttttctgtt gaagtttaca atgaaaggaa aatgatggtg atatttgtac cgtcactaga
     2101 aatgaagggc cctggcacac gggacttgga aagcatccag caataggccc tgcagcccat
     2161 gtggaggagc tgcagactgg agtccacccc tcctccccat cagggcgtct gtgctccagg
     2221 cttccttaat catggaggtg ctgagtcatc gctggctctc cctgtgggtc cagcatttcc
     2281 cataagcctc cttattgcac aaagaaagga aggaactcac attataactg atagtaggtt
     2341 cttgtttaga ctggatttac tgttaactct tttctaagta aatacagcat gtggtggtat
     2401 tttaaaatgt gttcccatgt gacaatttta taaaagtcag atatcttgca tttttatttc
     2461 aaaacataaa ttcagattta aaattatcag tgaatttgag ggattttgtt gttgccaatg
     2521 atacttttgg tgctgtgata agtaaatgaa agt
//
LOCUS       NM_001436901            1855 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 3 (B3gnt3), transcript
            variant 1, mRNA.
ACCESSION   NM_001436901 XM_017600026
VERSION     NM_001436901.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Shiraishi,N., Natsume,A., Togayachi,A., Endo,T., Akashima,T.,
            Yamada,Y., Imai,N., Nakagawa,S., Koizumi,S., Sekine,S.,
            Narimatsu,H. and Sasaki,K.
  TITLE     Identification and characterization of three novel beta
            1,3-N-acetylglucosaminyltransferases structurally related to the
            beta 1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 276 (5), 3498-3507 (2001)
   PUBMED   11042166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017600026.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.37947.1,
                                           SRR22582416.110235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680446, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               JAXUCZ010000016.1  18444618-18444851   c
            235-282             JAXUCZ010000016.1  18438493-18438540   c
            283-857             JAXUCZ010000016.1  18437035-18437609   c
            858-1855            JAXUCZ010000016.1  18435890-18436887   c
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1855
                     /gene="B3gnt3"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /db_xref="GeneID:290638"
                     /db_xref="RGD:1305151"
     exon            1..234
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..282
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    279..281
                     /gene="B3gnt3"
                     /note="upstream in-frame stop codon"
     exon            283..857
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1436
                     /gene="B3gnt3"
                     /EC_number="2.4.1.146"
                     /note="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 3"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 3 precursor"
                     /protein_id="NP_001423830.1"
                     /db_xref="GeneID:290638"
                     /db_xref="RGD:1305151"
                     /translation="MRLPRLRPVVSLLLALAALLLLLTCQSPPSCPAPESPTEPKDDP
                     AWAPDLSRAHAAPCRANLSVSAHPAFARLPSHVRDFLLYRHCRDFAVLREPKATKCAQ
                     PAFLLLAIKSSPANYGRRQVLRTTWARERRVRGASLRRLFLVGSDRDPQQARKFNRLL
                     ELEAKAYGDILQWDFHDSFFNLTLKQVLFLEWQRTHCTNASFVLNGDDDVFAHTDNMV
                     TYLQGRDPDQHLFVGHLIQNVGPIRVPWSKYFIPTLVTAEDKYPPYCGGGGFLLSRFT
                     MAALHRAARVLPIFPIDDVFLGMCLQQQGLAPGAHSGVRTAGVLPPSPRVSSFDPCFY
                     RDLLLVHRFLPFEMLLMWDALSRPQLACGRQSPPLLTGLGGRHP"
     sig_peptide     300..371
                     /gene="B3gnt3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    654..1223
                     /gene="B3gnt3"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     misc_feature    654..1223
                     /gene="B3gnt3"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     exon            858..1855
                     /gene="B3gnt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgaagaac gggacggaga gggacgaggt caaggagcca gaaggggact gagggggcgg
       61 cgggagggag gactttctcc ttggccactt ggaagctcct cttgctggag gaaggagtaa
      121 ggaaagagaa cggggaaaga ggcggagtaa ggcgagctgc caagagccag ggcgaggcgg
      181 acgcccaggt aaaaatcgtg tggcctccag ggctgtctgg agccggcgcc cgcggtacca
      241 accaagagac ctgggacagc agatacccca agacagactg aggccccgtc tcccacgcca
      301 tgcggctgcc gcggctgcgc cctgtcgtga gcctcctcct ggccttggcc gccttgctgc
      361 tgctcctgac ctgccagtca ccacccagct gccccgcccc cgagagtccc acggagccta
      421 aggatgaccc cgcgtgggcc ccggacctct cccgcgcgca cgccgccccg tgccgggcca
      481 atctgtcggt gtccgcacac cccgccttcg cgcggttgcc ctcgcacgtg cgcgacttcc
      541 tgctctaccg ccactgccgc gacttcgcgg tgcttcggga gccgaaggcg accaagtgcg
      601 cgcagcccgc gttcctgctg ctcgctatca agtcctcgcc cgcgaactac gggcgccgcc
      661 aggtgctgcg cacgacgtgg gcgcgtgaga gacgagtacg cggggcgtcg ctgcgccgcc
      721 tcttcctcgt gggctcagac cgcgatcccc agcaggcgcg caaattcaac cggctgctag
      781 agctggaggc aaaggcatac ggcgacattc tccagtggga tttccatgac tccttcttta
      841 acctgacact taagcaggtc cttttcctgg agtggcagcg aacccactgt accaacgcca
      901 gtttcgtgct caacggggac gacgacgtgt tcgcccatac ggacaacatg gtcacctacc
      961 tgcagggccg cgacccggac caacacctct tcgtggggca cctgatccag aacgtgggtc
     1021 ccattcgagt gccctggagc aagtacttca tccccactct ggtgacagct gaggacaagt
     1081 acccgcccta ctgcggcggc ggcggcttcc tgctgtcacg ctttaccatg gccgcgctac
     1141 atcgcgcagc gcgcgtcctc cccatcttcc ccatcgacga cgtgttcctg ggcatgtgtc
     1201 tgcagcagca ggggttggcg cccggggcgc atagcggagt gcgcacggcg ggtgtgctcc
     1261 cccctagccc gcgtgtgtca tccttcgacc cctgcttcta ccgtgacctg ctcctcgtgc
     1321 accgcttcct gcccttcgag atgctgctga tgtgggatgc gctgagccgg cctcagctcg
     1381 cctgcggcag gcagagcccc cccctactga caggtttggg gggtcgacac ccctgactcc
     1441 tgtcctcatt caagtgcaaa gggttaacta actacaagga gaggttcaaa gtgaggagca
     1501 gcaaggtggg tctgagccgg ctaccgtctg ccgggcaaac tcctaagtac acttggaaac
     1561 cctcctcgta ctgctcaggg cacactctga gtgggctctg agaggctgct aagcaaaaag
     1621 tgctgtgggt agagcccatg ggtgtcaggc tcccgcctca gactgggcca tggcctttct
     1681 caggtctcga agaaattggg gcagaggaac aaggtgaatt tcaaattgag gagctcacaa
     1741 atcttgactt gacccccact agtgtcctcc aagaactagg agaaccacag gggtaggaag
     1801 ggtcctgtgt cccacagatg gagatggcag gaaataaaga ccatagaagg ctgaa
//
LOCUS       NM_001099477            2532 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 70 (Vom2r70), mRNA.
ACCESSION   NM_001099477 XM_344197
VERSION     NM_001099477.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000014.1.
            
            On Jul 26, 2007 this sequence version replaced XM_344197.3.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000014.1  659083-659288
            207-489             JAXUCZ010000014.1  661849-662131
            490-1296            JAXUCZ010000014.1  662556-663362
            1297-1521           JAXUCZ010000014.1  664258-664482
            1522-1645           JAXUCZ010000014.1  665339-665462
            1646-2532           JAXUCZ010000014.1  666629-667515
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2532
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="vomeronasal 2 receptor, 70"
                     /db_xref="GeneID:364086"
                     /db_xref="RGD:1562647"
     CDS             1..2532
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 70"
                     /protein_id="NP_001092947.1"
                     /db_xref="GeneID:364086"
                     /db_xref="RGD:1562647"
                     /translation="MKKLCAFTIAFLILKFSLILFHLTEPSCFWRIKNSEETDGDLRS
                     DCGFVLFTFEEPIEENFYNQLINFRISARKYEFFLVMFFATDEINKNPYLLPNMSLIF
                     SLGDRMCKDTLGVLDQIYSQKNHSWHFINYVCGLERRCDIGLTGPSWTTSLKLAMDSR
                     TPKVFFGPLNSNLRDHEQFPYVHQIAIKDTRLPHGMVSLMLQFGWTWVGLIISDNDQG
                     IQFLSDLREEMQRHGICLAFVNMIPETMQIYMTKAKIYDQQLITSSAKVVIIYGEMNS
                     TLEVSFRRWAYLGEQRIWVTNSQWDVIINKTDFSLDFFHGTVTFAHHHSGMTIFRNVM
                     QTISTSKYPVDISQSMLGWNHFNCSISDNRHSKMDHFTFNNTLEWLALHKFDMVLSEE
                     GYNLYNAVYAVAHTYHELILQQVESQKVSKHKGLFTDCQQVASLLKTRVFTNPVGELV
                     NMNHRENQCAEYDIFIIWNFPQGLGLKVKIASYFPCFPHDQQLRISEDLEWATEGTLV
                     SSSMCSVTCIAGFRKIHQKQTADCCFDCVQCPENEVSNETADMEQCARCPDDKYANSE
                     QTYCLQRAVTYLAYEDSLGMALGCMALFFSVTTILVLVTFVKYKDTPIVKANNRILSY
                     ILLISLIFCFLCSLLFIGHPNKATCILQQITFGVFFSVAVSAVLAKTVTVVMAFKLTT
                     PGRRMRGMLALGAPNLVIPICTLIQLVLCGIWLVISPPFIDRDIQSEHGKTIIICNKG
                     SVIAFHFTLGYLGTLALMSFAVAFLARKLPDRFNEAKFLTFSMLVFYSVWITFLPVYH
                     STRGKVMVVVEVFSILASSAGLLGCIFVPKCYVILVRPDLNFLQK"
     misc_feature    133..1503
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    133..1503
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1174..1176)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1174..1176)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1528..1689
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1528..1689
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1750..2502
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..2502
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..1824
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1750..1824
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
     exon            207..489
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1296
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1521
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1645
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2532
                     /gene="Vom2r70"
                     /gene_synonym="RGD1562647"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaagc tgtgtgcttt cactattgcc tttttgatcc tgaaattttc tctaatcttg
       61 ttccacttga ctgaacccag ttgcttttgg aggataaaga atagtgaaga gactgatgga
      121 gatttgcgaa gtgactgtgg ttttgttctt ttcacatttg aggaacctat tgaagaaaat
      181 ttttataatc aacttattaa ttttagaata tcagcaagaa aatatgagtt ttttctggta
      241 atgttttttg ctactgatga gatcaacaag aatccttatc ttttacccaa catgtctttg
      301 atattctccc ttggtgatag aatgtgtaaa gatacattgg gagttctgga tcaaatttat
      361 tcacaaaaaa accatagttg gcattttatt aattatgtct gtggactaga gcgccgttgt
      421 gacataggtc ttacagggcc atcatggacc acatccttaa aactggcgat ggattccagg
      481 actccaaagg ttttctttgg accacttaac tctaacctaa gagaccatga gcagtttccc
      541 tatgtccatc agatagcaat caaagacaca cgtttgcctc atggcatggt atccttgatg
      601 cttcaatttg gatggacttg ggtaggactg atcatctcag ataatgacca gggtattcag
      661 tttctctcag acttgagaga agaaatgcaa aggcatggga tctgtttggc ttttgtgaat
      721 atgatcccag aaaccatgca gatatacatg acaaaagcta agatatatga ccaacaactt
      781 ataacatcat cagcaaaggt tgttatcatt tatggtgaaa tgaactctac tctagaagtc
      841 agctttagaa gatgggcata tttaggtgaa caaagaatct gggtcactaa ctcacaatgg
      901 gatgtcatca taaataaaac agatttcagc cttgatttct tccatgggac tgtcactttt
      961 gcacaccacc acagtgggat gactatattt aggaatgtta tgcaaacaat aagcacttcc
     1021 aagtacccag tagacatttc tcagtctatg ctagggtgga atcattttaa ttgttcaatc
     1081 tctgacaata gacatagcaa aatggatcat tttacattca acaatacatt agaatggtta
     1141 gcactgcaca aatttgacat ggtcctgagt gaagaaggtt acaatttgta taatgctgtg
     1201 tatgctgtgg cccacaccta ccatgaactc attttacaac aagtagagtc tcagaaagta
     1261 tcaaaacaca aaggattatt cactgactgt cagcaggtgg cttccctgct gaaaaccagg
     1321 gtatttacta accctgttgg agaactggtg aacatgaacc atagggaaaa tcagtgtgca
     1381 gagtatgaca ttttcatcat ttggaatttt ccacagggcc ttggattaaa agtgaaaata
     1441 gcaagctatt ttccttgttt cccacatgat caacaacttc gtatatcaga agacttggag
     1501 tgggccacgg aaggaacatt ggtttcatcc tccatgtgta gtgtgacatg tattgctgga
     1561 ttcaggaaaa ttcatcagaa acaaacagca gactgctgct ttgattgtgt tcagtgccca
     1621 gaaaatgagg tttccaatga gacagcagat atggaacagt gtgcgaggtg tccagatgat
     1681 aaatatgcca actcagagca gacctactgc ctccaaagag ctgtgacata tctggcttat
     1741 gaagattcac tgggaatggc tctgggctgc atggccctgt tcttctcagt caccacaatt
     1801 ctagtactag tcacatttgt gaagtacaag gatactccca ttgtgaaagc caataaccgc
     1861 attctcagct acatcctgct catctctctc atcttctgtt ttctctgttc attgctcttc
     1921 attggacatc ccaacaaggc cacctgcatc ctgcagcaga tcacatttgg agtgtttttc
     1981 tctgtggctg tttctgcagt gttggccaaa acagtaactg tggtcatggc ttttaagctc
     2041 actactccag ggagaaggat gagagggatg ctggccttag gggcacctaa cttggtaatt
     2101 cccatttgta ccctaatcca acttgttctc tgtggaatct ggttggtaat atctcctccc
     2161 tttattgaca gagatataca atctgaacat gggaagacca tcattatttg caacaaaggc
     2221 tcagtcattg cattccactt taccctggga tacttgggca ctttggctct gatgagcttt
     2281 gctgtggcat tcttggcaag gaaacttcct gacagattca atgaagccaa gttcctaaca
     2341 ttcagcatgt tggtgttcta cagtgtatgg atcaccttcc ttcctgtcta ccacagtacc
     2401 agagggaagg ttatggtagt tgtggaggtc ttttccattt tggcttctag tgcagggttg
     2461 ctagggtgta tctttgtccc aaagtgttat gttattttag ttagaccaga tttaaatttt
     2521 cttcagaagt aa
//
LOCUS       NM_022243               1769 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus 3-hydroxyisobutyrate dehydrogenase (Hibadh),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022243 XM_342686
VERSION     NM_022243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Murin,R., Schaer,A., Kowtharapu,B.S., Verleysdonk,S. and
            Hamprecht,B.
  TITLE     Expression of 3-hydroxyisobutyrate dehydrogenase in cultured neural
            cells
  JOURNAL   J Neurochem 105 (4), 1176-1186 (2008)
   PUBMED   18284611
  REMARK    GeneRIF: The expression of 3-hydroxyisobutyrate dehydrogenase in
            neural cells demonstrates their potential to utilize valine
            imported into the brain for the generation of energy.
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Loupatty,F.J., van der Steen,A., Ijlst,L., Ruiter,J.P., Ofman,R.,
            Baumgartner,M.R., Ballhausen,D., Yamaguchi,S., Duran,M. and
            Wanders,R.J.
  TITLE     Clinical, biochemical, and molecular findings in three patients
            with 3-hydroxyisobutyric aciduria
  JOURNAL   Mol Genet Metab 87 (3), 243-248 (2006)
   PUBMED   16466957
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Hawes,J.W., Harper,E.T., Crabb,D.W. and Harris,R.A.
  TITLE     Structural and mechanistic similarities of 6-phosphogluconate and
            3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the
            3-hydroxyacid dehydrogenases
  JOURNAL   FEBS Lett 389 (3), 263-267 (1996)
   PUBMED   8766712
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Rougraff,P.M., Zhang,B., Kuntz,M.J., Harris,R.A. and Crabb,D.W.
  TITLE     Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate
            dehydrogenase. Evidence for its evolutionary relationship to other
            pyridine nucleotide-dependent dehydrogenases
  JOURNAL   J Biol Chem 264 (10), 5899-5903 (1989)
   PUBMED   2647728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            J04628.1 and AA859729.1.
            
            On Dec 24, 2005 this sequence version replaced XM_342686.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127442.1, J04628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                J04628.1           1-62
            63-1725             J04628.1           64-1726
            1726-1769           AA859729.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1769
                     /gene="Hibadh"
                     /note="3-hydroxyisobutyrate dehydrogenase"
                     /db_xref="GeneID:63938"
                     /db_xref="RGD:708399"
     exon            1..120
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1040
                     /gene="Hibadh"
                     /EC_number="1.1.1.31"
                     /note="3-hydroxyisobutyrate dehydrogenase, mitochondrial"
                     /codon_start=1
                     /product="3-hydroxyisobutyrate dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_071579.1"
                     /db_xref="GeneID:63938"
                     /db_xref="RGD:708399"
                     /translation="MAASLGFRGAASGLRYWSGRRRPVGSLAAVCSRSMASKTPVGFI
                     GLGNMGNPMAKNLIKHGYPLILYDVFPDVCKEFKEAGEQVASSPADVAEKADRIITML
                     PSSMNSIEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSG
                     GVGAARSGNLTFMVGGVENEFAAAQELLGCMGSNVLYCGAVGSGQSAKICNNMLLAIS
                     MIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSSNNYQGGF
                     GTTLMAKDLGLAQDSATSTKTPILLGSVAHQIYRMMCSKGYSKKDFSSVFQYLREEET
                     F"
     transit_peptide 33..137
                     /gene="Hibadh"
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P29266.3)"
     mat_peptide     138..1037
                     /gene="Hibadh"
                     /product="3-hydroxyisobutyrate dehydrogenase,
                     mitochondrial. /id=PRO_0000007160"
                     /note="propagated from UniProtKB/Swiss-Prot (P29266.3)"
     misc_feature    159..1022
                     /gene="Hibadh"
                     /note="3-hydroxyisobutyrate dehydrogenase; Region: HIBADH;
                     TIGR01692"
                     /db_xref="CDD:130753"
     misc_feature    159..1022
                     /gene="Hibadh"
                     /note="3-hydroxyisobutyrate dehydrogenase; Region: HIBADH;
                     TIGR01692"
                     /db_xref="CDD:130753"
     misc_feature    207..209
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    255..257
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    390..392
                     /gene="Hibadh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    462..464
                     /gene="Hibadh"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    474..476
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    741..743
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    753..755
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     misc_feature    990..992
                     /gene="Hibadh"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99L13; propagated from
                     UniProtKB/Swiss-Prot (P29266.3); acetylation site"
     exon            121..281
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            282..391
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            392..513
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            514..647
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            648..724
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            725..881
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1753
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcacggcg cggaggcggg gcgtggggca gcatggcagc ctccttgggg ttccgggggg
       61 cagcctccgg cctccggtac tggagcggcc ggcggcggcc cgtgggcagc cttgcagcgg
      121 tgtgttctag gtcaatggct tctaagactc cagttggatt cattggactg ggaaacatgg
      181 gcaatccaat ggcaaaaaat ctcataaaac atggctaccc actcatcctc tatgatgtgt
      241 tccctgacgt atgcaaagag tttaaagagg ctggtgaaca ggtagcgtcc tccccagcag
      301 atgtagcgga aaaggctgac aggattatca caatgctgcc ctccagtatg aattcaatag
      361 aagtttattc tggagcaaat ggaattctaa aaaaagtgaa gaaaggctca ttattaatag
      421 attccagtac tattgatcct tcagtttcaa aagaattggc aaaagaagtt gagaaaatgg
      481 gagctgtttt catggacgcc cctgtttctg gtggcgtagg agctgctcgg tctggaaacc
      541 ttacattcat ggtgggagga gttgaaaatg agtttgctgc tgcccaagag ttgctggggt
      601 gcatgggctc caatgtattg tactgtggag ctgtcgggtc tgggcagtct gcaaagatct
      661 gtaacaacat gctgttggct ataagtatga tcggaactgc tgaagctatg aaccttggaa
      721 tcaggtcagg ccttgaccca aaactattgg ctaaaatcct gaatatgagc tcaggacgat
      781 gctggtccag cgacacttac aaccctgtac ctggggttat ggatggagtt ccctcatcta
      841 ataactacca aggtggattt gggacaacac tcatggccaa ggatctggga ttagctcaag
      901 actctgccac cagcaccaag accccaattc tcctcggaag cgtggcccat cagatataca
      961 ggatgatgtg ttcaaagggc tactcaaaga aagacttctc ctctgtgttc cagtatctgc
     1021 gggaggagga aaccttctga ctgccctgtg gtcatggaca ctgttaggaa ccaaactctg
     1081 tcctgagctt ccttctagct cattctagaa gtcatgggtt taatcaaagg tcatctgtct
     1141 gcttttgatt gtctacatta tagcaatccc tggggatttt tatccatttt aaatgctgct
     1201 gctttcatct gtttagcaaa cacacccaat ggtttccact gactagccca gttgaccttt
     1261 ttaagtttga accttgagca ccttaaacaa aattgagcac tctgatcagg atattttatt
     1321 tactctgctt tacaaataaa accaaatgtt ttgttaacaa gatggaaccc atggtaaaaa
     1381 aggaaagaaa tcagttacaa agacaaatta gagggaaatt tgtcctgtta accacgtgct
     1441 attattcctt cattctgggt tactgactta ctgtgcaggg gttgataggt aagacagctt
     1501 gctatacttg tcttcctgtc tcgattgtta cagtatctta gtgtaccctc ctgttacagc
     1561 ttcctcactc agccggcttg cttctgtatt tttgcttcct gtatatcctt ttactacatg
     1621 tttttgactc cagaaaaatg acaccgttag actgtttcag agccaatgat gatatttcct
     1681 ttagataatt attatattat tctaactata gtcatattat tttggattta aataaatttc
     1741 tatcctgata acaaaaaaaa aaaaaaaaa
//
LOCUS       NM_001436927            3229 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus SERTA domain containing 4 (Sertad4), transcript
            variant 1, mRNA.
ACCESSION   NM_001436927 XM_039090943
VERSION     NM_001436927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039090943.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.3386871.1,
                                           SRR26643291.34720.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840117 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000013.1  106899644-106899905 c
            263-454             JAXUCZ010000013.1  106895333-106895524 c
            455-570             JAXUCZ010000013.1  106894215-106894330 c
            571-3229            JAXUCZ010000013.1  106889074-106891732 c
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..3229
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA domain containing 4"
                     /db_xref="GeneID:360899"
                     /db_xref="RGD:1565408"
     exon            1..262
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    82..84
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="upstream in-frame stop codon"
     exon            263..454
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1380
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /codon_start=1
                     /product="SERTA domain-containing protein 4"
                     /protein_id="NP_001423856.1"
                     /db_xref="GeneID:360899"
                     /db_xref="RGD:1565408"
                     /translation="MTLVLSMNRFCEPIVSEGAAEIAGYHTLWEADSYGGASPPGPAH
                     VPSQGDRGAGPQLAGSHYRGISNPVSTPKVTYFKRKYAEEEELPTPLSSCSHKTISIF
                     EERAHILYMSLEKLRFIDDPEVYLRRSVLINNLMKRIHGEIVMQNSWYLPACSLSGTS
                     AQEWFLAQDCPYRKRPRVAKQEWEKFHTCCFYQECGGHCLNLPLSVSDGVGSASAAAV
                     ASPASSSSSPSTSSPSSPSSSSSSLSSPLPLPSCSHHVDFDVGSAPIYKSQVPASEIF
                     VTNVRSLGVQEKIKFNSDGKVSHETSRDGNALGQEPVGNDLDFECKGQFYDYFETGYT
                     ERNRMSESWKKSLRKKELSPSNKLCCSRGGKM"
     misc_feature    601..705
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA motif; Region: SERTA; pfam06031"
                     /db_xref="CDD:461806"
     misc_feature    601..705
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /note="SERTA motif; Region: SERTA; pfam06031"
                     /db_xref="CDD:461806"
     exon            455..570
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
     exon            571..3229
                     /gene="Sertad4"
                     /gene_synonym="RGD1565408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcttgtca ggttccctct cgccccgggg gcatccagca gagccaggct cggaaatccg
       61 cggggaaatg gcaaacagga ttgacgggtt tctcgcgctc ctcgccagac acagcggctc
      121 atttccataa ccgtctgcgg cggcggcggg acctgcgggg acctcggccg ccgcgcaccg
      181 ggccacgccg acagggcccg ggaggcgcgt gggcagcggc ggccgcgcgg aggacggcgg
      241 cggctggagc gcagggcgcg cgatctaagg ctgttagaga tgacgctggt tctgtccatg
      301 aatagattct gcgagcccat tgtctcagaa ggagctgctg aaattgccgg gtaccacaca
      361 ctatgggagg ctgacagcta cggaggtgcg agccccccag ggccagcaca tgttccttca
      421 cagggagacc ggggagccgg cccacaactg gcaggatcac attacagggg gatttcaaac
      481 cctgtaagca cacccaaggt cacgtacttc aagaggaagt atgcggaaga agaggagctt
      541 cccacaccgc tcagcagctg cagccataag accatctcca tttttgagga gcgagcacac
      601 atcctttaca tgtccttgga gaaactcagg ttcatcgatg acccagaagt gtacctgcga
      661 aggtcagtcc ttatcaacaa tctgatgaag aggatccacg gggagatcgt catgcagaac
      721 agctggtacc tccctgcctg ctccctcagt ggcacctctg cccaagagtg gttcctggct
      781 caagactgtc cttaccggaa acggccccgg gtggccaaac aggagtggga aaagttccac
      841 acttgctgtt tttaccagga gtgtggcggt cactgcctga acctacccct ctctgtcagt
      901 gatggtgtcg gaagcgcttc ggccgctgcc gtggcctcac ctgcttcttc ctcttcctcc
      961 ccatccacct cttctccatc ctccccatcc tcctcgtcct cgtccttgtc ctcccctctg
     1021 cctctgccca gttgttccca ccacgtggac tttgacgtag gcagtgcgcc tatttacaag
     1081 agccaagttc ctgccagcga aatctttgtc actaacgtta ggtcgcttgg tgtccaggaa
     1141 aagatcaagt tcaacagcga cgggaaagta agtcacgaaa ccagcagaga tggcaacgcc
     1201 ctgggccaag aacctgtggg aaacgacctc gattttgagt gcaaaggcca attttatgat
     1261 tatttcgaga ctggatatac cgagagaaac cgtatgagtg agtcttggaa aaagtctttg
     1321 aggaaaaagg agctttcccc aagcaacaaa ctgtgctgca gcagaggggg taaaatgtga
     1381 ccccccctcc cccaccccca actggcgcag aagcacgcac agcatgatcg gtttttactt
     1441 tgggttttgt agttttgtac aaccgataaa atcacgcagt gaacacgccc ggtcgtctca
     1501 ctgcccggag agcagattgc acaaaacatc tgtacagtag gcatccacaa gccacttatt
     1561 aatgtgattt ttgccaagga aagccaactt catgtttcaa agtatatcct agtttccttt
     1621 ttttctaaaa aaaaaaaaat taaaaaaaaa aatcagtaga gtagatcgaa gacaacatgc
     1681 ccttgttatg ttcccactgc ccctccacgg agcctgccgc tagccaagtt caacatgttt
     1741 gccggttaat taggtagtta cttggtaaac aaatcaatat aaccagcaaa ggtgcctgct
     1801 tcgatgtgat acggtatttt ttccccctga gtgaaagact gaaggcagga agctagatga
     1861 agtggtttcg tgagctgtga catgtttgta ctggacaggt tggggcgaaa tgaagcacac
     1921 ctgtcaggca gcagtctagg ctctgtggag tcagttccct acaagctcct ggcttgcctg
     1981 tgatggctag tgggtggcta gagaggggtg tgcagggcca cctctgacgg ggtcacaggg
     2041 aggtgatgta cagagccgtc tctgatgggg cgagtaggag gtggcacaca gagccatctt
     2101 tgatggggtg gctagagagg tggcgtacag ggccatcttg gtgatggggt gataggtggc
     2161 gtatagggcc atcttgggtg ccttacttta tcttaatttt tgccagtgtg aaaattaagg
     2221 acgaatcaga gttacagcag ggatttgaca aaacacaggg tggatccatg cagtttggaa
     2281 gcttaacttt gaactatcgt gttcaacttt caagttaccc tccccctttt tcctttgttt
     2341 atgactaagc ccagtggctg tgagtctgat atttttgcgt agagacggag aagacagtgg
     2401 ggaaggccat caggaacaga gaaggctgcc tgggttctcc atggcaacga gcggttgctg
     2461 ggtctggact ctcccagctt tgggctgttt tgtttccttg tccagtgaca ttcacagccc
     2521 gtgcgtggca tgcgttatat ttttgacctg tttttgcatc atttcatgcg tttagactct
     2581 taagagcatg tggtttctat atacgaattt ttgctgttga ttgagaagca caatgttaat
     2641 agattatgtg gtgatcaata tgttttatct taaagaatgt aaaggtttgt aggttgctga
     2701 acgttatttt ggagaaatgg ggctctctcg tcattgatac tgttgtgtat ttggccgaca
     2761 cactcctcaa taccttgaat ttgcacattg gcaagtgtcc tcagtgctac tctggagcag
     2821 tcccaccagc tccccgtgaa ctactcccat ctccaaggcc aaggactggt ctgggtgacc
     2881 tgggtctctt aaaaaccatt atttacagga aacaaatgcc aaaaggaaga aataggtaag
     2941 ttctcccact ttctccaaga tgaagctttt taattattgc tattgatatt aaataggtct
     3001 cattcataca gtgtatgagt agatcgtttg ggcaattgtc cgcaaggacc aattttctaa
     3061 agatgttcct gtgttatggc tgaatagtct agtaatgtct cgtcctttat tttcaatatt
     3121 tgatgaacat tttggtgttg gaaatttagc tgatagatgc ttgtacatga ctgtgttgta
     3181 atatagtgag gttttcttga tatatattta ttaaaacgat caaaattca
//
LOCUS       NM_001014135            2844 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus WD repeat domain 1 (Wdr1), mRNA.
ACCESSION   NM_001014135 XM_341228
VERSION     NM_001014135.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Lechuga,S., Baranwal,S. and Ivanov,A.I.
  TITLE     Actin-interacting protein 1 controls assembly and permeability of
            intestinal epithelial apical junctions
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (9), G745-G756 (2015)
   PUBMED   25792565
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Luxenburg,C., Heller,E., Pasolli,H.A., Chai,S., Nikolova,M.,
            Stokes,N. and Fuchs,E.
  TITLE     Wdr1-mediated cell shape dynamics and cortical tension are
            essential for epidermal planar cell polarity
  JOURNAL   Nat Cell Biol 17 (5), 592-604 (2015)
   PUBMED   25915128
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Yuan,B., Wan,P., Chu,D., Nie,J., Cao,Y., Luo,W., Lu,S., Chen,J. and
            Yang,Z.
  TITLE     A cardiomyocyte-specific Wdr1 knockout demonstrates essential
            functional roles for actin disassembly during myocardial growth and
            maintenance in mice
  JOURNAL   Am J Pathol 184 (7), 1967-1980 (2014)
   PUBMED   24840128
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Song,J.J., Adler,H.J., Lee,H.S., Jang,J.H., Park,M.H., Lee,J.H.,
            Chang,S.O. and Oh,S.H.
  TITLE     WDR1 expression in normal and noise-damaged Sprague-Dawley rat
            cochleae
  JOURNAL   J Comp Neurol 521 (7), 1470-1481 (2013)
   PUBMED   22821633
  REMARK    GeneRIF: elevated WDR1 expression after acoustic overstimulation in
            the current experiments may provide a mechanism for protection
            against noise exposure.
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Doukhanine,E., Gavino,C., Haines,J.D., Almazan,G. and Richard,S.
  TITLE     The QKI-6 RNA binding protein regulates actin-interacting protein-1
            mRNA stability during oligodendrocyte differentiation
  JOURNAL   Mol Biol Cell 21 (17), 3029-3040 (2010)
   PUBMED   20631256
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Kile,B.T., Panopoulos,A.D., Stirzaker,R.A., Hacking,D.F.,
            Tahtamouni,L.H., Willson,T.A., Mielke,L.A., Henley,K.J.,
            Zhang,J.G., Wicks,I.P., Stevenson,W.S., Nurden,P., Watowich,S.S.
            and Justice,M.J.
  TITLE     Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory
            disease and macrothrombocytopenia
  JOURNAL   Blood 110 (7), 2371-2380 (2007)
   PUBMED   17515402
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Fujibuchi,T., Abe,Y., Takeuchi,T., Imai,Y., Kamei,Y., Murase,R.,
            Ueda,N., Shigemoto,K., Yamamoto,H. and Kito,K.
  TITLE     AIP1/WDR1 supports mitotic cell rounding
  JOURNAL   Biochem Biophys Res Commun 327 (1), 268-275 (2005)
   PUBMED   15629458
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085864.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341228.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085864.1, AY986483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2844
                     /gene="Wdr1"
                     /note="WD repeat domain 1"
                     /db_xref="GeneID:360950"
                     /db_xref="RGD:1305789"
     exon            1..29
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="Wdr1"
                     /note="upstream in-frame stop codon"
     CDS             14..1834
                     /gene="Wdr1"
                     /note="WD repeat protein 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 1"
                     /protein_id="NP_001014157.1"
                     /db_xref="GeneID:360950"
                     /db_xref="RGD:1305789"
                     /translation="MPYEIKKVFASLPQVERGVSKILGGDPKGDNFLYTNGKCVILRN
                     IDNPAVADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHILKYEYQPFA
                     GKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQNRPY
                     RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDG
                     KTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS
                     NVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGK
                     SYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVDESGQLVSCSMDDTVRYTN
                     LTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEV
                     VAVHPGGDTVAVGGSDGNVRVYSILGATLKDEGKLLEAKGPVTDLAYSHDGAFLAVCD
                     ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET
                     KVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY"
     misc_feature    23..148
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 1"
     misc_feature    95..97
                     /gene="Wdr1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); acetylation site"
     misc_feature    155..274
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 2"
     misc_feature    173..1180
                     /gene="Wdr1"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    173..1180
                     /gene="Wdr1"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    order(182..184,236..238,248..250,266..271,311..316,
                     368..370,392..394,410..415,443..448,500..502,515..517,
                     533..538,575..577,626..628,641..643,659..664,698..700,
                     710..712,764..766,776..778,794..799,965..970,1025..1027,
                     1040..1042,1058..1063,1100..1105,1154..1156,1166..1168)
                     /gene="Wdr1"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    order(182..184,236..238,248..250,266..271,311..316,
                     368..370,392..394,410..415,443..448,500..502,515..517,
                     533..538,575..577,626..628,641..643,659..664,698..700,
                     710..712,764..766,776..778,794..799,965..970,1025..1027,
                     1040..1042,1058..1063,1100..1105,1154..1156,1166..1168)
                     /gene="Wdr1"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    197..313
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    197..313
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    254..256
                     /gene="Wdr1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); acetylation site"
     misc_feature    290..418
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 3"
     misc_feature    296..298
                     /gene="Wdr1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); acetylation site"
     misc_feature    326..442
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    326..442
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    356..358
                     /gene="Wdr1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); acetylation site"
     misc_feature    398..1828
                     /gene="Wdr1"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    398..1828
                     /gene="Wdr1"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    425..541
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 4"
     misc_feature    461..571
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    461..571
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    551..667
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 5"
     misc_feature    587..697
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    587..697
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    683..802
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 6"
     misc_feature    722..832
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    722..832
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    725..727
                     /gene="Wdr1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); phosphorylation site"
     misc_feature    821..931
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 7"
     misc_feature    944..1066
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 8"
     misc_feature    986..1096
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    986..1096
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1085..1237
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 9"
     misc_feature    1307..1435
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 10"
     misc_feature    1346..1474
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1346..1474
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1451..1567
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 11"
     misc_feature    1451..1453
                     /gene="Wdr1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75083; propagated from
                     UniProtKB/Swiss-Prot (Q5RKI0.3); acetylation site"
     misc_feature    1487..1561
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1487..1561
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1580..1696
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 12"
     misc_feature    1616..1729
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1616..1729
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1709..1825
                     /gene="Wdr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI0.3);
                     Region: WD 13"
     misc_feature    1748..1825
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1748..1825
                     /gene="Wdr1"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            30..151
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..242
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..390
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..571
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..649
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..730
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..964
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1052
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1209
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1297
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1408
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1582
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1727
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..2813
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagtaggcg aggatgccgt acgagatcaa gaaggtgttc gccagcctcc cccaggtgga
       61 gcggggtgtc tctaagatcc tcggcggaga ccccaagggc gataatttcc tctacaccaa
      121 tggcaagtgc gtcatcctga ggaacatcga caaccctgct gttgctgaca tctacacaga
      181 acacgcccat caggtggtag tagccaagta tgcacccagc ggattctaca ttgcttctgg
      241 agatatctct gggaagctaa ggatctggga taccacacag aaggagcaca ttctaaagta
      301 tgagtaccag cctttcgctg ggaagatcaa ggacatagcc tggaccgaag acagtaagag
      361 gatcgccgtg gtcggggaag gaagggagaa atttggagct gtcttcttat gggacactgg
      421 ctcttctgtg ggtgagatca caggacacaa caaagtcatt aacagcgtgg acatcaagca
      481 gaacaggccc taccgactag caacagggag tgacgataac tgtgctgcat tcttcgaggg
      541 ccccccattc aagttcaagt ttacaattgg tgaccacagc cgctttgtca actgtgtgcg
      601 attctctcct gatgggaaca gatttgccac agctagtgct gatggccaga ttttcattta
      661 tgatgggaag acaggagaaa aggtgtgtgc ccttggagga agcaaggctc atgatggagg
      721 aatttatgcc attagttgga gtcctgatag cacccatttg ctatctgcct ctggagacaa
      781 aacctctaag atttgggatg tcaatgtaaa ctctgtggtc agcacgtttc ccatgggctc
      841 caatgttctg gaccagcagc tgggctgcct ctggcagaag gaccacctcc ttagcatctc
      901 cctgtctgga tacatcaact acctggacaa aaataacccc agcaagcccc tccgggtcat
      961 caagggtcac agtaaatcca tccagtgtct gacagtgcac aaaaatggtg gcaaatccta
     1021 catctattct gggagccatg atggccatat taattactgg gattcagaga caggagagaa
     1081 tgactccttc tctggaaaag gccacacaaa tcaggtgtcc aggatgactg tggacgagtc
     1141 tgggcagttg gtcagctgca gcatggacga cacagtgcgg tatactaacc tcacactgag
     1201 ggactacagt ggacaaggcg ttgtgaaact ggatgttcag ccaaagtgtg tagctgttgg
     1261 ccctggggga tataccgtgg tcgtgtgcat tggacagatt gtccttctga aggaccagaa
     1321 gaaatgcttc agcatcgaca accctggcta cgagcctgaa gttgttgctg tgcaccctgg
     1381 tggggacaca gtagctgttg gtggctcgga tggcaatgtg cgtgtgtact ccatcctggg
     1441 tgccacacta aaggatgaag gcaaactcct agaggccaag gggccagtga cagacttggc
     1501 ctactctcat gacggtgcct tcctggctgt gtgtgatgcc agcaaggtgg tcacagtgtt
     1561 cagtgtagct gatggctatt cggagaataa tgttttttat ggacaccatg caaaaattgt
     1621 gtgcctggcc tggtcaccag ataatgaaca ctttgcctct ggcggcatgg acatgatggt
     1681 atatgtgtgg acactgagtg acccagagac caaagtcaag attcaagatg cccaccggct
     1741 gcaccacgtc agcagtctgg cctggctgga cgaacacaca ctggtcacca cctcccatga
     1801 cgcctctgtg aaggagtgga caatcaccta ctgaggacac cgctcacccc acggaccgaa
     1861 tcagggacta gagttaactg cctcggagca cccttctctt aactatttct gtaacgctcc
     1921 ccttcctgcc tgccctggga gtggggaggg cctgcgagta ccctcctctc ttcagggtgt
     1981 ccatgtctgt acgcgtcctt ctgagagctt tagacagtaa cagtttgcac acaagaaata
     2041 aagcgagcac taaaacagca gtggagcgag cctaagaact tacagcccac cagaccgtga
     2101 gcggggagca ttccagaggc agcagcctcc aagcacagcc caagcccctg cggctctgca
     2161 gcttaccagg gctgggtagg gagcaggcca cggctcccct ttctcatgca ggatgcagtg
     2221 cactggggag gagcagccgc tgtgcagagc tgtcagcatt ctgtgtagag caggtctgtt
     2281 cctctgtaag tcatgttaca cggctgcctc cctggagcta tccccgatcc cacggggaca
     2341 tgtgaacctt gatctcattg tcagattttg tgcttgattt ttaagaatgg aatcatgaga
     2401 attttttttt tttttaacgt atcttgactg ttgtctgtct tgttcctgac ctggcgcgct
     2461 gacagtgctt gtccagacaa gtagagccct ggttagccag actgaggtgt cctggtcatg
     2521 tgattaccac gcttcaatgt ttccctgtct cttcccaact ctggccccaa gagcaagatt
     2581 aaggacaaga tgatgttgct gtaatttgtc atgtttttac cttttttttc tttttcagtg
     2641 cagaaattaa agtaagtata aagcaccgtg attggcagtt tctttgcgtg tgtcggaatc
     2701 actggtaaat gttggctgag aacaatccct ccccttgcac ttgtgaaaac actttgaacg
     2761 ctttaagagt aattagactg agaaataatt aaatatcttt tctcttgatt gtgaaaaaaa
     2821 aaaaaaaaaa aaaaaaaaaa aaaa
//
LOCUS       NM_001436929            6029 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3),
            transcript variant 3, mRNA.
ACCESSION   NM_001436929 XM_039092046
VERSION     NM_001436929.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6029)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 6029)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 6029)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 6029)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 6029)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 6029)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039092046.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35306.1,
                                           SRR26643295.49483.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000014.1  83684312-83684495   c
            185-320             JAXUCZ010000014.1  83674558-83674693   c
            321-369             JAXUCZ010000014.1  83628633-83628681   c
            370-454             JAXUCZ010000014.1  83627427-83627511   c
            455-532             JAXUCZ010000014.1  83614191-83614268   c
            533-622             JAXUCZ010000014.1  83611592-83611681   c
            623-739             JAXUCZ010000014.1  83611102-83611218   c
            740-822             JAXUCZ010000014.1  83604938-83605020   c
            823-989             JAXUCZ010000014.1  83602356-83602522   c
            990-1086            JAXUCZ010000014.1  83592224-83592320   c
            1087-1200           JAXUCZ010000014.1  83588725-83588838   c
            1201-1406           JAXUCZ010000014.1  83583226-83583431   c
            1407-1538           JAXUCZ010000014.1  83582300-83582431   c
            1539-1650           JAXUCZ010000014.1  83581721-83581832   c
            1651-1846           JAXUCZ010000014.1  83575932-83576127   c
            1847-2032           JAXUCZ010000014.1  83575039-83575224   c
            2033-2203           JAXUCZ010000014.1  83574230-83574400   c
            2204-2349           JAXUCZ010000014.1  83572847-83572992   c
            2350-3754           JAXUCZ010000014.1  83570317-83571721   c
            3755-3865           JAXUCZ010000014.1  83568961-83569071   c
            3866-3954           JAXUCZ010000014.1  83568438-83568526   c
            3955-6029           JAXUCZ010000014.1  83564065-83566139   c
FEATURES             Location/Qualifiers
     source          1..6029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..6029
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..184
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..320
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..369
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..454
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..532
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    515..517
                     /gene="Mtmr3"
                     /note="upstream in-frame stop codon"
     CDS             530..4126
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="isoform 3 is encoded by transcript variant 3;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 3"
                     /protein_id="NP_001423858.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MDEEMRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEY
                     VGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFP
                     TFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRN
                     SCRGFPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWL
                     DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNM
                     VPLASRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQE
                     PQLDDATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVE
                     NIAEDRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSE
                     SGPQLHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAP
                     CALPLDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSH
                     QLSATSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQR
                     LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQN
                     CLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGN
                     VFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    596..877
                     /gene="Mtmr3"
                     /note="Myotubularian (MTM) related 3 protein (MTMR3)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR3; cd13341"
                     /db_xref="CDD:270149"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    1034..1984
                     /gene="Mtmr3"
                     /note="protein tyrosine phosphatase-like domain of
                     myotubularin related phosphoinositide phosphatase 3;
                     Region: PTP-MTMR3; cd14586"
                     /db_xref="CDD:350434"
     misc_feature    3872..4054
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    3872..4054
                     /gene="Mtmr3"
                     /note="FYVE domain found in myotubularin-related protein 3
                     (MTMR3) and similar proteins; Region: FYVE_MTMR3; cd15732"
                     /db_xref="CDD:277271"
     misc_feature    order(3875..3877,3884..3886,3938..3955,3959..3964,
                     4034..4042)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     misc_feature    order(3875..3877,3884..3886,3938..3955,3959..3964,
                     4034..4042)
                     /gene="Mtmr3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277271"
     exon            533..622
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..739
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..989
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1086
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1200
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1406
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1538
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1650
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1846
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2032
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2203
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2349
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3754
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3865
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..3954
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..6029
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccgc tgccgccatg ttgttgtggt tgtgagaagg cggcggcggc agcggtggcg
       61 gcggagcagc cggtggagac gctccagcgg cccaggcgct gccccccgcc gaccctggct
      121 ggcagcctcc tggggtggcg gaggaggccg tgcggtggcg ggcctcgcca tgtcctgcct
      181 cccgagtacc tggtgacctg ttttgactct ccatttggaa gggcctggtc tgtaccattg
      241 taaacatgct ttaccgagtt gtgatgactg ctcctcctcc ttgtttttgg cctgggaact
      301 gagcccaagg tcttatccag atttccttgt aaaaccttgt agaagaaaaa gttctcagga
      361 agatacttgt gcatcggagt cagaggctgg tgcaagctgg ctagccagag aaccaaatca
      421 gtgaaccccc agttctacag cagatcctgc cttagtctca agcagaagag aaagaagaac
      481 cttgtcagag actggagaag gacggggtct ctcctgacct ggtctggtca tggatgaaga
      541 gatgcggcat agccttgagt gcatccaggc caatcagatc tttcccagga agcagctgat
      601 tcgggaggat gaaaatcttc aggttccttt ccttgaactc catggagaga gcacagagta
      661 tgtgggccgt gctgaggatg ccatcattgc cctctctaat tacagacttc acatcaagtt
      721 taaggagtct cttgtgaatg ttccattaca gcttatagaa agcgttgaat gccgtgatat
      781 atttcagctt cacttgacat gcaaagactg caaagttatc aggtgtcagt tcccaacctt
      841 tgagcagtgt caagattggc ttaagagatt aaacaatgca atccgaccac ctggaaaaat
      901 agaagatctc ttctcatttg cataccatgc ttggtgcatg gaggtctatg ccagtgaaaa
      961 agagcagcat ggagacctgt gcagaccagg ggaacatgta acgtcaaggt ttaagaatga
     1021 agtggagcgg atgggttttg atatgaacaa tgcctggagg atttccaaca tcaatgagaa
     1081 atacaaatta tgtggtagtt atccacaaga gctcatagta cctgcctgga tcactgacaa
     1141 agaactagaa agcgtggcag gcttcagatc ctggaagcgc atccccgccg tcatctacag
     1201 gcaccagagc aatggagccg tcattgcccg ctgcggacag cccgaggtta gctggtgggg
     1261 ctggcggaat gctgatgatg aacatctggt gcagtcagtg gccaaggctt gtgcttctga
     1321 ctctcagtca agtgttggca aggtttccac tcggaacagt tgtcggggct ttcccaatgc
     1381 aggggatctt tctgatgtgg agttcgatgc ctctctgtca aatgcttcag gaacagaaag
     1441 tttagctctc cagccacaga agcttttgat cttggacgca cgctcctatg cagcagctgt
     1501 ggcaaatcga gccaaaggag ggggctgtga gtgtccagag tattatccaa actgtgaagt
     1561 tgtgtttatg ggaatggcaa acatacattc tatccggagg agtttccagt ctctgcgact
     1621 gctgtgcaca cagatgccag atcctggaaa ttggctttct gctcttgaaa gtacgaagtg
     1681 gctccaccac ctgtctgtgc ttctgaagtc ggcacttctc gtggtgcatg ctgtggaccg
     1741 agatcagcga ccagtgctgg tgcactgctc agatggctgg gatcgcactc cccaaatcgt
     1801 ggccctggct aagcttctgc tggaccctta ttaccgaacc gtagagggtt tccaagtcct
     1861 tgtggagatg gaatggctgg attttggcca taagtttgct gatcggtgtg gtcatgggga
     1921 gaactcagat gacctgaatg agcgttgccc agtgtttctc caatggcttg actgtgttca
     1981 tcaactccag aggcaatttc cttgctcttt tgagttcaac gaagcattcc ttgtgaagct
     2041 ggttcagcac acctattcct gtctctttgg gacattcctg tgcaacaacg ccaaggagag
     2101 gggggagaag cagactcagg aacggacatg ctcggtgtgg tcgcttctgc gggccggcaa
     2161 caaggccttc aaaaacctgc tatattcatc ccagtcagaa gccgtgctgt accctgtgtg
     2221 ccatgtgcgg aatctgatgc tgtggagtgc agtgtacctt ccctgcccgt ccccatccac
     2281 ccccacagac gacagctgtg caccataccc agccccaggc accagccctg atgagcctcc
     2341 actgagccgg ctacccaaga ctagatcatt tgacaatctg accacaacct gtgacaacat
     2401 ggtgccgctg gccagccggc gcagcagtga ccccagcctg aatgagaagt ggcaggagca
     2461 cgggcgctcg ctggagttga gcagctttgc tggctctggg gaagaggtgc ctgccataga
     2521 cagcctgcgc aggcccagca ggctgctcgg aggagccgag ctatctgtgg cagctggtgt
     2581 ggctgaaggg cagatggaga atattttgca agaggccacc aaagaggaga gtggggtaga
     2641 agagcccacc cacagggagc acactgaggt gccagaggtc aaagaggagg cacccctagc
     2701 aaaagagagt aggacggcag ctcagggctc aggtgtactt taccaagaac cacagctgga
     2761 tgatgctact ctaaggagcc atttaggccc cagcctgtct tcgttctccc agggtattcc
     2821 tgagcatcgg gaggtggggc acagtgttct ctctagttca ctcccagctt ctctcagggg
     2881 agaggactcc caggaggtcc ctgtagaaca gcctcaagta gagaacattg cagaggacag
     2941 ggagaatgta gtccctgctg tcccagtaga tgtaaaaatt ggccttggta cctcagagtc
     3001 tagtcctctg ctgccttccc aagtcccatt cgagacaaga ggaccacaca tgaacaactc
     3061 cgtgcacatg ttattagaag ataaggtgaa gtccgagagt gggccccagc tccatcacag
     3121 accctgcctg gcaagcagtg gtagattcag tggcaaggac atgcttccta tagcaccaga
     3181 gcccaggtct gctgagaggc cccagtggga ctctgtgcta cacaggactt cttcccctgg
     3241 caacaccctc agcctgatga tgcaggctcc ttgtgccttg ccattagaca aatgtagaca
     3301 gagaattgtg tgcaacggtg ccctagagac tgaaaacaag gcctcagaac agcctgcagg
     3361 gtttgacacc cttcagaagt accccacacc caatgggcat tgtgccaatg gggagactgg
     3421 gaggagtaag gactcactga gccaccagct gtctgccaca agctatagct ctgctcactc
     3481 gtgctcaagg aacttgcacc acaagtggct gaatagccac tcggggaggc catccactac
     3541 caacagccct gagcagcctt cccgcagcca cctggatgat gacggcatgc ctgtgtacac
     3601 agacacgatc caacagcgcc tgcgacagat agagtctggt caccagcagg aagtggagac
     3661 cttgaagaaa caagtccagg aactgaagag tcgcctggag agccagtacc tgaccagctc
     3721 tctgcgcttc aatggggact ttggagatga agtgacttca atccccgact cggaaagcaa
     3781 tctggatcag aactgtttgt ctcgctgcag cacagagatt ttctctgaag ccagctggga
     3841 gcaggtggat aaacaggaca cagagatgac ccgttggcta cctgaccact tggctgccca
     3901 ctgctatgcc tgtgacagtg ccttctggct tgccagtagg aagcaccact gcaggaattg
     3961 tgggaacgta ttctgctcca gttgttgtaa ccagaaggtt ccagttccca gccagcagct
     4021 ctttgaaccc agtcgagtgt gcaagtcttg ctatagcagc ctccatccca caagctccag
     4081 cattgacctt gaactggata agcctattgc tgccacttca aactgaagct cagtgacctg
     4141 gggtgacaga ggccatgctg ctgtccctgt aacaggctca cacacagcct gggcagtccg
     4201 agaagcccat acattttgga tgggggcatg gaacaacctg tacagagatt ggggtgtacc
     4261 actggatcgt agatcgattt tcctttcctt ccccttccct ttccatcctc ctctttgcct
     4321 tctaaaaaga aaaatgtccc agttgtctta atttttttta atggaagccc agaggttacc
     4381 aggctcttag aactgctgag tggcttgctg tcgggcactc tgtgacatca ctcagtgctt
     4441 ccctatggaa ggaggcacaa tgaaggcctg agacagcagg acagaaagcc agcctaccat
     4501 taatgaccgt tctccacatg aagctgtgcc acagttgact ggtgcacctt tgcagctggg
     4561 gaggctggaa gcccttttct tgagtactgt tcctcagagg gatagatagg gccatcctac
     4621 ctcacagaca aaaagcagga tggtgttgag aggaagcaca cagtgaagtg ctccacaggc
     4681 ctcactttga aaagagaggt atgtgcttct tttgagttac tgagggccta gatggctgac
     4741 atgttggccc aggtggatcc atctttaaca agattgggta gggctttctt tgcttcttta
     4801 ggcttccaga ccaaaaggta cagactggcc agaaagcagt atcctgctgc agtggtcaag
     4861 gcctgcactg agctgggcac ctgaggtccc cctctgggtc ctagtcccat aagcaatctc
     4921 ttcctcagcc aacacaggga aatccagact cagggttcca cagtctcctg ttcccaaagc
     4981 aaaccaatca tgcatctccc cttgagggac agatccccac agttccgaag ctctccacac
     5041 aatcagcctt cctctcttac ttctgggcag caggaaggac ccaggagtcc cttgtcctgc
     5101 ttttggctgc ctgagtgggc acatgtctgg ctcttgctat cagtgaagag cccttggtga
     5161 ttgtagggtt cttagaagat gacatggctg aggagattcg gggtaccttc ccgtagtgag
     5221 ctttgatgtg gtccaaaaag agccttaagt ctgtagttat ctgtgctgga ggtgggtatg
     5281 aagggtagag agcagttttg gtttgtactt tgaattgttg gcatctgtct gtgcccaccc
     5341 catcccccaa gggtgatgct tggctctgcc aaaagctgca atctggtaac agagcagatt
     5401 atagtgttgg ggctgggtga ggctgggtga ggctggggga cacctaattt tagcctggcc
     5461 tatgtccttg ctcctctcct ctggaagctg ttacctggcc atgggccttc cgtgtctcag
     5521 gaaggtggct tctgcatgtt cctcagtatg actggagaag ccagagcctt cccagcagtt
     5581 gtgtgctgaa gggaaggctg cagtctccga gtattgctgg tccttcagga gcaggccggg
     5641 cagaggccga gtttagtgaa acagggtgaa gttctccaag ctcgctgtgg tctggagttg
     5701 cgggtgggga aggtcggcat aactgaagac tgcagttcct agtgagaggt gccaagaggt
     5761 tatgatacgg gtgtcttggg tctgttgtac agtgtgaata agtgcttgca gctcttagcc
     5821 ctttttgatc aatgaagcac ttttttatta atattttctt tgtatgtaaa ggaggaaccg
     5881 taactctcca tagctgtaca tataacccct ttctcctaaa gaggagtccg tgctcctata
     5941 tttttcattt tttgtcaaag caagaagtaa atactttaga attgttaaat acatagataa
     6001 agtgaataaa gttgagtgtc agcaaggtg
//
LOCUS       NM_001436853            2985 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus heterochromatin protein 1, binding protein 3
            (Hp1bp3), transcript variant 3, mRNA.
ACCESSION   NM_001436853
VERSION     NM_001436853.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Dutta,B., Yan,R., Lim,S.K., Tam,J.P. and Sze,S.K.
  TITLE     Quantitative profiling of chromatome dynamics reveals a novel role
            for HP1BP3 in hypoxia-induced oncogenesis
  JOURNAL   Mol Cell Proteomics 13 (12), 3236-3249 (2014)
   PUBMED   25100860
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Dutta,B., Ren,Y., Hao,P., Sim,K.H., Cheow,E., Adav,S., Tam,J.P. and
            Sze,S.K.
  TITLE     Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as
            a Novel Regulator of Cell Cycle Progression
  JOURNAL   Mol Cell Proteomics 13 (9), 2183-2197 (2014)
   PUBMED   24830416
REFERENCE   3  (bases 1 to 2985)
  AUTHORS   Hayashihara,K., Uchiyama,S., Shimamoto,S., Kobayashi,S.,
            Tomschik,M., Wakamatsu,H., No,D., Sugahara,H., Hori,N., Noda,M.,
            Ohkubo,T., Zlatanova,J., Matsunaga,S. and Fukui,K.
  TITLE     The middle region of an HP1-binding protein, HP1-BP74, associates
            with linker DNA at the entry/exit site of nucleosomal DNA
  JOURNAL   J Biol Chem 285 (9), 6498-6507 (2010)
   PUBMED   20042602
REFERENCE   4  (bases 1 to 2985)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16714.1,
                                           SRR26643284.8234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000005.1  155719734-155719766
            34-133              JAXUCZ010000005.1  155724942-155725041
            134-287             JAXUCZ010000005.1  155726205-155726358
            288-447             JAXUCZ010000005.1  155728962-155729121
            448-591             JAXUCZ010000005.1  155732660-155732803
            592-669             JAXUCZ010000005.1  155734814-155734891
            670-821             JAXUCZ010000005.1  155735359-155735510
            822-912             JAXUCZ010000005.1  155738870-155738960
            913-1072            JAXUCZ010000005.1  155740995-155741154
            1073-1184           JAXUCZ010000005.1  155742543-155742654
            1185-1301           JAXUCZ010000005.1  155743955-155744071
            1302-2985           JAXUCZ010000005.1  155744646-155746329
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2985
                     /gene="Hp1bp3"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
     exon            1..33
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            34..133
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1599
                     /gene="Hp1bp3"
                     /note="isoform b is encoded by transcript variant 3"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform b"
                     /protein_id="NP_001423782.1"
                     /db_xref="GeneID:313647"
                     /db_xref="RGD:735099"
                     /translation="MPIRRAVNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEPE
                     NETPPAPSREAEQPKGEPESGEKEESKSAEETKKEEKDQSKEKEKKVKKTIPAWATLS
                     ASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLDLER
                     RGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSKTPQKSKNRKKGSAVDPEPQVK
                     LEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQ
                     ITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPG
                     TNSNYQMHLLKKTLQKCEKNGWLEQISGKGFSGTFQLCFPYYPSPGVLFPKKVSDGSE
                     DEDEEEDEEESSEDSEDEEPPPKRSLQKKTPAKPQGKTASMKQRGAKPARKVPAAQRG
                     KVRPLPKKAPPKAKTPARKGRPAPSAVKKPSGSTSKKPVANARKEAKLPGKGKSAMKK
                     KSFKTKK"
     misc_feature    400..654
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    400..654
                     /gene="Hp1bp3"
                     /note="linker histone 1 and histone 5 domains; the basic
                     subunit of chromatin is the nucleosome, consisting of an
                     octamer of core histones, two full turns of DNA, a linker
                     histone (H1 or H5) and a variable length of linker DNA;
                     H1/H5 are chromatin-associated...; Region: H15; cd00073"
                     /db_xref="CDD:238028"
     misc_feature    order(421..423,457..459,553..555,595..597)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    order(421..423,457..459,553..555,595..597)
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    538..573
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    538..573
                     /gene="Hp1bp3"
                     /note="DNA-binding site [nucleotide binding]; DNA binding
                     site"
                     /db_xref="CDD:238028"
     misc_feature    727..909
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    727..909
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    955..1158
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    955..1158
                     /gene="Hp1bp3"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    <1342..>1566
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     misc_feature    <1342..>1566
                     /gene="Hp1bp3"
                     /note="adenylate kinase; Provisional; Region: PRK13808"
                     /db_xref="CDD:172341"
     exon            134..287
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            288..447
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..591
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..669
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..821
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..912
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1072
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1184
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1301
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..2985
                     /gene="Hp1bp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgtgg ccgccattac ggagttccca gtgaaagcag acgatagcac catgcctatc
       61 cgtcgggctg tgaattctac tcgggaaact ccgcccaaaa gcaaacttgc tgaaggggaa
      121 gaagaaaaac cagaaccaga tgggagttca gaggagtcta tctctacggt agaagaacca
      181 gagaatgaga ctccacctgc tccatccagg gaggcagagc agcccaaggg ggagcctgag
      241 agtggagaga aggaagagag caagtctgct gaggaaacca agaaagaaga gaaggatcag
      301 tctaaagaaa aggagaagaa agtgaagaaa accatccctg cctgggccac tctgtctgcc
      361 agccagctag ccagggccca gaaacaaacc ccaatggctt cctccccacg gccaaagatg
      421 gatgcaatct taactgaggc cattaaggca tgcttccaga agagcggtgc ctccgtggtt
      481 gctatccgga agtacatcat tcataagtac ccttctctgg atctggagag aaggggctat
      541 ctcctcaagc aagcactgaa aagagagtta aacagaggag tcatcaaaca ggtaaaagga
      601 aaaggtgcat ctggcagttt tgtcgtggtc cagaaatcaa aaacacctca gaaatccaaa
      661 aacagaaaga agggctctgc agtggatcca gaaccacaag taaaactgga agatgttctc
      721 ccattggctt ttacccgact ctgtgaacct aaggaagcct cctacagtct catcaggaaa
      781 tacgtgtctc agtattaccc taagcttcga gtggacatca ggccccagtt gttgaagaat
      841 gctctgcaga gagcagtgga gagaggccag ttagagcaga taactggcaa gggtgcttcg
      901 gggacattcc agctgaagaa atccggggag aaacccctgc ttggtggaag cctgatggaa
      961 tatgcaatct tgtctgccat tgctgccatg aatgaaccta agacctgctc caccactgct
     1021 ctgaagaagt atgtcctgga gaaccaccca gggaccaatt ctaactacca aatgcatttg
     1081 ctgaaaaaaa ctctgcagaa atgtgagaag aatgggtggc tggagcagat ctctgggaag
     1141 gggttcagcg gcaccttcca gctgtgcttc ccctattacc ccagcccagg agttctgttt
     1201 ccaaagaaag tgtcagatgg ctctgaggat gaggatgagg aggaggatga agaggagtca
     1261 tcagaggact ctgaggatga agagccgcca cccaagagga gcttacagaa gaaaacacca
     1321 gccaagcccc aagggaagac ggcctccatg aagcagagag gggctaagcc tgcgcgtaaa
     1381 gtccctgctg cccagagagg gaaggtgagg ccgctgccta agaaagctcc gcccaaggct
     1441 aagacccctg ccaggaaagg cagacccgca ccctcagccg tcaagaagcc tagcgggagc
     1501 acctccaaaa agcctgtagc caatgcacga aaggaagcga aactgcccgg taagggcaaa
     1561 tctgccatga agaagaagtc tttcaagaca aaaaagtaaa ttttatagga aaaagggtat
     1621 catgattgaa ttcagaatct tattttataa ggtcagtgtg catttgtttt agttataatg
     1681 cttttaaatt ttacattttt cttcccatac gaacactgtg ggaaggaatg taaacaaacc
     1741 agtgtagaca tttgttggct taggtgctgt tctcagtgcc tgcttcttca tcattttaat
     1801 ttctgccgta atcctggact tggctgaact gtgtaactac cctgctccct ttgttcatct
     1861 taacccaacc ctcattctct tctttttgtg atccaatttg gggttttctt ttcctcctcg
     1921 aagttaatcc aaacagttgc aaagatgcat ttgtagtgag tacctccagg tctggtgctg
     1981 aagccagacg gagcgggagc actacaggga cagcattgct tcctgcctgg ggacttgctg
     2041 attgaccctg gctgtgaaat cactccacta acctttctcc agcgtgggcc agggacatta
     2101 taactttgga aagaagcccc agtctgccat ccatagattc tgaagatctc ttctcctttg
     2161 ctgtctgccc agttgccaag cacgccctgc tgcccagagc gttgttccct taacagcaag
     2221 cgcacgtctg cgccacctgc tttctgactg aaggggaagt acaggaatat gtggaatctg
     2281 attgcttatt accaaaaatg acagaatatt cttgatcaaa ggcctagata tatttttaat
     2341 atttggggca tgagcttccc ctgtttgaga gttcccatta ctgaggtaga aatgttaatt
     2401 tgctaaacat aatttgctaa aatgaccagt tttcagattc acctgtgcgt gtgcccccac
     2461 tcgcacccca ccccattctc tccatagaac gtttgctgtc agctcggcgg tctccatttc
     2521 gaggtgttta tcagaagcga ggaggggagc aaatgaagcc gtgctgccca gccctcctcg
     2581 tcttgtattt gtttaggttg tgaggttgtg taaatagtag cttcctactt gagaactaca
     2641 gctcctgctt atcattgatc ctttcctgtg gcacttaata ttttaattgt cttaagcttt
     2701 tgatgtacat cctctggccc cttacacgct gccagaggag aaggtgtttg agattcattc
     2761 cacttgaagt gtctttcctg ggctccccac agctgcagat ggctgggaag tggacttgag
     2821 gaatgggctc gaattggtgg ttcatgcctg tgaggaccca tcatgagtca tcgggatttg
     2881 tgttgcatgg aaggcaatct ttcctgttgt aaatcttcct tttttatgta catatatttt
     2941 gaaaatatga ataaacatga aattttaaaa gctgctgaac tacaa
//
LOCUS       NM_001436906            5327 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus DEP domain containing 5, GATOR1 subcomplex
            subunit (Depdc5), transcript variant 3, mRNA.
ACCESSION   NM_001436906 XM_017599212
VERSION     NM_001436906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5327)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   2  (bases 1 to 5327)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   3  (bases 1 to 5327)
  AUTHORS   Marsan,E., Ishida,S., Schramm,A., Weckhuysen,S., Muraca,G.,
            Lecas,S., Liang,N., Treins,C., Pende,M., Roussel,D., Le Van
            Quyen,M., Mashimo,T., Kaneko,T., Yamamoto,T., Sakuma,T., Mahon,S.,
            Miles,R., Leguern,E., Charpier,S. and Baulac,S.
  TITLE     Depdc5 knockout rat: A novel model of mTORopathy
  JOURNAL   Neurobiol Dis 89, 180-189 (2016)
   PUBMED   26873552
  REMARK    GeneRIF: DEP-domain containing 5 knockout rats exhibit multiple
            features of rodent models of mechanistic target of rapamycin
            complex 1 (mTOR) mTORopathies, and thus, stand as a relevant model
            to study their underlying pathogenic mechanisms.
REFERENCE   4  (bases 1 to 5327)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   5  (bases 1 to 5327)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   6  (bases 1 to 5327)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   7  (bases 1 to 5327)
  AUTHORS   Dibbens,L.M., de Vries,B., Donatello,S., Heron,S.E., Hodgson,B.L.,
            Chintawar,S., Crompton,D.E., Hughes,J.N., Bellows,S.T., Klein,K.M.,
            Callenbach,P.M., Corbett,M.A., Gardner,A.E., Kivity,S., Iona,X.,
            Regan,B.M., Weller,C.M., Crimmins,D., O'Brien,T.J.,
            Guerrero-Lopez,R., Mulley,J.C., Dubeau,F., Licchetta,L.,
            Bisulli,F., Cossette,P., Thomas,P.Q., Gecz,J., Serratosa,J.,
            Brouwer,O.F., Andermann,F., Andermann,E., van den Maagdenberg,A.M.,
            Pandolfo,M., Berkovic,S.F. and Scheffer,I.E.
  TITLE     Mutations in DEPDC5 cause familial focal epilepsy with variable
            foci
  JOURNAL   Nat Genet 45 (5), 546-551 (2013)
   PUBMED   23542697
REFERENCE   8  (bases 1 to 5327)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_017599212.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.43835.1,
                                           SRR26643298.55084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000014.1  82087178-82087257   c
            81-203              JAXUCZ010000014.1  82086314-82086436   c
            204-291             JAXUCZ010000014.1  82082754-82082841   c
            292-338             JAXUCZ010000014.1  82081990-82082036   c
            339-424             JAXUCZ010000014.1  82076632-82076717   c
            425-508             JAXUCZ010000014.1  82075101-82075184   c
            509-558             JAXUCZ010000014.1  82073810-82073859   c
            559-628             JAXUCZ010000014.1  82065166-82065235   c
            629-707             JAXUCZ010000014.1  82059994-82060072   c
            708-769             JAXUCZ010000014.1  82057813-82057874   c
            770-839             JAXUCZ010000014.1  82054640-82054709   c
            840-912             JAXUCZ010000014.1  82053717-82053789   c
            913-1016            JAXUCZ010000014.1  82051584-82051687   c
            1017-1091           JAXUCZ010000014.1  82050570-82050644   c
            1092-1226           JAXUCZ010000014.1  82048741-82048875   c
            1227-1288           JAXUCZ010000014.1  82048313-82048374   c
            1289-1362           JAXUCZ010000014.1  82048015-82048088   c
            1363-1432           JAXUCZ010000014.1  82041033-82041102   c
            1433-1469           JAXUCZ010000014.1  82039384-82039420   c
            1470-1590           JAXUCZ010000014.1  82038588-82038708   c
            1591-1811           JAXUCZ010000014.1  82034655-82034875   c
            1812-2015           JAXUCZ010000014.1  82028524-82028727   c
            2016-2151           JAXUCZ010000014.1  82026612-82026747   c
            2152-2246           JAXUCZ010000014.1  82025608-82025702   c
            2247-2312           JAXUCZ010000014.1  82017612-82017677   c
            2313-2496           JAXUCZ010000014.1  82013892-82014075   c
            2497-2657           JAXUCZ010000014.1  82013290-82013450   c
            2658-2775           JAXUCZ010000014.1  82007658-82007775   c
            2776-2943           JAXUCZ010000014.1  82007016-82007183   c
            2944-3163           JAXUCZ010000014.1  82006023-82006242   c
            3164-3297           JAXUCZ010000014.1  82004307-82004440   c
            3298-3403           JAXUCZ010000014.1  81995949-81996054   c
            3404-3555           JAXUCZ010000014.1  81987025-81987176   c
            3556-3633           JAXUCZ010000014.1  81984251-81984328   c
            3634-3766           JAXUCZ010000014.1  81983350-81983482   c
            3767-3875           JAXUCZ010000014.1  81976926-81977034   c
            3876-4103           JAXUCZ010000014.1  81975276-81975503   c
            4104-4273           JAXUCZ010000014.1  81971181-81971350   c
            4274-4445           JAXUCZ010000014.1  81967616-81967787   c
            4446-4506           JAXUCZ010000014.1  81964695-81964755   c
            4507-4589           JAXUCZ010000014.1  81960418-81960500   c
            4590-5327           JAXUCZ010000014.1  81959560-81960297   c
FEATURES             Location/Qualifiers
     source          1..5327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5327
                     /gene="Depdc5"
                     /note="DEP domain containing 5, GATOR1 subcomplex subunit"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
     exon            1..80
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            81..203
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..4882
                     /gene="Depdc5"
                     /note="isoform 3 is encoded by transcript variant 3; DEP
                     domain-containing protein 5; GATOR complex protein DEPDC5;
                     GATOR1 complex protein DEPDC5"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform 3"
                     /protein_id="NP_001423835.1"
                     /db_xref="GeneID:305464"
                     /db_xref="RGD:1311535"
                     /translation="MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHP
                     NDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
                     TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEET
                     RVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTV
                     VLFSRTFYDAKSIDEFPEVNRASIQQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKK
                     LFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSV
                     VITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPRDSR
                     LGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSATEKTKNGRDTSLGAPKESE
                     NTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHNRKSASSCDVSSSPSLPS
                     RALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIEPPQ
                     RDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVG
                     PSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDSMSL
                     NFSGTEELSVSLLSNSGTGMNPRNQNKDSLEDGVSTSPDPILTLSAPPVVPGFCCTVG
                     VDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVF
                     EEFICQRLMQGYQIIVQPKTQKPSTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMG
                     RTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFCHERLEE
                     YKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKP
                     RADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLESTGP
                     PVGKKGTSALSALLEMEASQKSLGEQQTSVHGKSSTQPAENSSVAMTPTYVDSPRKAS
                     VDQTAPLVLDSTSLGVSTCQSVDRGNNQTFGNSQNIEQAFPSTGSGDGSSQQHIASSL
                     TSSSTLVEILEAMKHPSTGVQLLSEQKGLSPCCFISAEVVHWLMNNVEGVQTQAMGID
                     IMQKMLEEQLIAHASGEAWRTFVYGFYFYKIVTDREPERVAMQQPSAPWHTAGVDDFA
                     SFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLA
                     ATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTATVLFEMVQ
                     GWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNLGCLLKEGSEHLFDSFE
                     PETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRK
                     FSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFT
                     DFCINRDNRLVTFWTNCLEKMHASAP"
     misc_feature    446..1288
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    446..1288
                     /gene="Depdc5"
                     /note="Vacuolar membrane-associated protein Iml1; Region:
                     IML1; pfam12257"
                     /db_xref="CDD:463510"
     misc_feature    3605..3850
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3605..3850
                     /gene="Depdc5"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in DEPDC5-like proteins. DEPDC5, in human also known
                     as KIAA0645, is a DEP domain containing protein of unknown
                     function; Region: DEP_DEPDC5-like; cd04449"
                     /db_xref="CDD:239896"
     misc_feature    3902..4825
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     misc_feature    3902..4825
                     /gene="Depdc5"
                     /note="DEPDC5 protein C-terminal region; Region:
                     DEPDC5_CTD; pfam19418"
                     /db_xref="CDD:466071"
     exon            204..291
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            292..338
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            339..424
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            425..508
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..558
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            559..628
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            629..707
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            708..769
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            770..839
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..912
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1016
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1091
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1226
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1288
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1362
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1432
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1469
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1590
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1811
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2015
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2151
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2246
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2312
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2496
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2657
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2775
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2943
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3163
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3297
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3403
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3555
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3633
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3766
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3875
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..4103
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4273
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4445
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4506
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4589
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..5327
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgagcgc tgttcggcgg tgctgtctgt ctggctccta gagctctggt gcggaagctg
       61 cgcgaactgt gggggctcag tagcaggaag gcaagatgac ttccctgctc caagatcgga
      121 acagctgaag aaaccacaag acaaaatgag aaccacaaag gtctacaaac ttgtcatcca
      181 caagaagggc tttgggggca gtgatgatga gctggtcgtg aaccctaaag tctttcctca
      241 catcaaactt ggagacattg tggagatcgc tcaccccaat gatgaataca gtcctttgct
      301 tttgcaagtc aagtctctta aggaagattt acagaaagaa actatcagtg tggaccagac
      361 tgtgacacaa gtattccggc taagacctta tcaagatgtc tatgtaaacg ttgtagaccc
      421 caaggatgtg actcttgacc tagtggaatt gacttttaag gatcagtata taggccgggg
      481 ggatatgtgg cgactaaaga aaagtttggt gagcacctgt gcctatatca cccagaaagt
      541 ggaatttgct ggcatcaggg cacaggctgg tgagctgtgg gtcaagaatg agaaggtcat
      601 gtgtggttac attagtgaag agaccagggt ggtgttccgt tctacgtcgg ctatggttta
      661 catatttatt cagatgagct gtgaaatgtg ggattttgat atttatgggg atctgtactt
      721 tgagaaagct gtgaatggtt tccttgccga cctgtttact aagtggaagg agaagaactg
      781 tagccatgaa gtgactgtgg ttctgttttc tagaactttt tatgatgcaa aatctattga
      841 tgaatttcct gaagtaaacc gagcttcaat tcaacaggat cataaaggga gattctacga
      901 ggacttttac aaagtggtgg tgcagaacga gagaagggaa gagtggacgt cactccttgt
      961 gaccattaag aaactcttca tccagtatcc agtgttggtt cgactggaac aggcaggggg
     1021 ctttcctcaa ggagacaatt ctacctcagc acaaggaaac tacctagagg ccatcaactt
     1081 gtcattcaat gtgtttgaca agcactacat caaccgaaac tttgaccgaa ctgggcagat
     1141 gtccgtggtg atcacgccgg gggtgggtgt ctttgaagtg gaccgcctcc tcatgatctt
     1201 gaccaagcag cggatgatcg ataatggaat tggtgtggac ttagtgtgca tgggagagca
     1261 gccattacac gctgtgccat tattcaagct gcacaaccgg agtgtgccac gggattctcg
     1321 gctgggcgat gactataata ttcctcactg gataaaccac agtttctaca catccaaaag
     1381 ccagctgttt tgtaacagtt tcactccaag gataaaactg gcaggaaaga agtctgccac
     1441 tgagaaaacc aaaaatggcc gtgatacatc tcttggggct ccaaaggaat ctgaaaacac
     1501 ccttcccatc caagtagatt atgatgccta cgatgcccaa gtattccggc tgcctggtcc
     1561 atcccgggcc cagcgactcg ccacctgcag gtctgtgaga gagcaggaaa atcacaatcg
     1621 caaaagtgcc agctcctgtg acgtctcctc cagcccttcc ttgccaagcc gtgcactgcc
     1681 cactgaggaa gtgaggagcc aggcttcaga cgacagctcc ctgggcaaga gcaccaacat
     1741 cctgatgatc cctaaccccc atctgcacca gtatgaagtc agcagctcac tgggctacac
     1801 cagcacccga gatgtcctgg agaacatgat agaaccacca cagcgggact ctagtgcacc
     1861 tggaaggttc cacgtgggca gtgcagagtc catgctacat gttcgacctg gaggctacac
     1921 ccctcagaga gcactgatta accccttcgc cccctcaaga atgcccatga agctcacctc
     1981 caacagaagg cgctggatgc atacttttcc tgtaggacca tctggagagg ccatccagat
     2041 ccatcatcaa acccggcaaa acatggcaga gctgcagggc agcaggcagc gggaccccac
     2101 ccactcctct gcagaactgt tggagctggc atatcatgaa gccgcaggaa ggcacagcac
     2161 ttcccgacag cctggtgaca gcatgtcctt gaacttcagt ggaacggaag agctttctgt
     2221 cagcctgctt agcaacagcg gcacaggtat gaatcctagg aaccagaata aggactctct
     2281 agaggatggt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt
     2341 gccaggcttc tgttgcacag ttggagtgga ttggaagtct cttactactc ctgcatgcct
     2401 tcccctcacc actgactact tcccggaccg tcagggcctg cagaatgact acacagaggg
     2461 ctgctatgat ctcctcccag aagcagacat ggacaggagg gacgaggagg gcgttcaaat
     2521 gacagcccag caagtgtttg aagagttcat ctgccagcgt ctcatgcagg gttaccaaat
     2581 catagtacag ccaaagaccc agaagcccag cactacagtc ccacccccgc tgagcagtag
     2641 cccactctat agcagaggcc ttgtgtcccg aaaccgccct gaagaggagg gccagtattg
     2701 gctgagtatg ggcagaacct tccataaggt gacacttaag gacaagatga tcacagtgac
     2761 tcgttacctt cccaagtacc cttatgaatc tgcccagatc cattacacct acagcctctg
     2821 cccttcccac tctgactcag agtttgtctc ctgttgggtg gaattctgcc atgaacggct
     2881 agaggaatac aagtggaatt acttagatca gtacatttgt tctgccggct ccgaagattt
     2941 cagcttaatc gagtctctga agttctggag aacccgattt ctactactgc cagcctgtgt
     3001 cactgccacc aagcgcatca cagaagggga agtgcactgt gacatctacg gggacaaacc
     3061 ccgtgcagat gaagatgagt ggcagcttct agatggcttt attcgctttg tagagggctt
     3121 gaaccgcatc cgcaggcgcc accggtcaga ccgcatgatt cggaaaggga ctgccatgaa
     3181 aggcttgcag atgaccgggc ccatctccgc acactctctc gagtcaacgg gccccccagt
     3241 cgggaagaaa ggaacctcag ctctgtctgc cctgctggag atggaggcta gtcagaagag
     3301 cctaggagaa cagcagacaa gtgtgcatgg gaaaagctct actcagccag ctgagaacag
     3361 cagtgttgcc atgactccca cctatgtgga cagcccacgc aaggcatctg tggaccaaac
     3421 agctcctctg gtgttggaca gcaccagttt aggggtcagc acgtgccagt ccgtggatag
     3481 aggcaataac cagacctttg ggaactccca gaacatagaa caggcctttc cctctacagg
     3541 ctctggagac ggcagctctc agcagcacat agccagctct ctgacatcgt cctctaccct
     3601 ggtggagatc ctggaagcca tgaagcatcc ctcgacagga gtccagctgc tgtctgagca
     3661 gaagggcctt tcgccgtgct gcttcatcag tgcggaggtc gtacactggc tgatgaacaa
     3721 tgtggagggg gtccagacgc aggcgatggg catcgacatc atgcagaaaa tgctggaaga
     3781 gcagctcata gcgcatgcat ctggagaagc atggcgaacc ttcgtctacg gcttctattt
     3841 ctacaagata gtcacggaca gagagcccga acgagtggct atgcagcagc cctctgcccc
     3901 atggcacaca gcaggagtgg atgactttgc cagcttccaa cgcaagtggt ttgaggtggc
     3961 ctttgtggca gaagagcttg tgcactccga gattcctgcc ttcctcctgc cctggctacc
     4021 tagccggcca gcctcttacg caagcaggca cagctccttt agccgaagtt ttggaggacg
     4081 gagccaggca gctgcactgt tagctgccac tgtcccagag cagaggactg tgaccctgga
     4141 tgtcgatgtg aacaaccgaa cggaccggct ggagtggtgc agctgttact accacggaaa
     4201 cttctctctc aacgcagcct ttgaaatcaa gctacactgg atggcagtga ctgccacagt
     4261 gctgtttgag atggtccaag gttggcatcg aaaagctaca tcctgcggct tcttgttagt
     4321 cccggttttg gagggtcctt ttgcactgcc cagttacctg tacggtgacc ccttgagggc
     4381 ccagctcttc atcccgctca acctcggctg cttgctcaag gagggcagcg agcacctgtt
     4441 cgatagcttt gaaccagaga catattggga tcgaatgcac cttttccagg aagccattgc
     4501 acacaggttt ggatttgtgc aagataaata ttctgcctcc gcgtttaact tccctgctga
     4561 gaataaacca cagtatatcc acgtcacagg aacagtgttt cttcagctgc cgtactccaa
     4621 acgcaagttt tctgggcagc agcggcggcg acggaactct accagctcca ccaaccaaaa
     4681 catgttctgt gaggagcggg ttggctacaa ctgggcctat aacaccatgc tgaccaagac
     4741 atggcgctct agtgccacgg gggatgagaa gtttgccgat cggctgctga aggacttcac
     4801 ggatttctgt atcaaccgtg acaaccgcct ggtcacattc tggacaaact gcctggagaa
     4861 gatgcacgcc agcgctccct gacgccaggc tgctccatta ggagaggctg tgggtatcct
     4921 ggagctggct gtccagctag gctctgggca tcaggtgtca ggctgctcct gtcagcgagt
     4981 ggggccactg ctgatatttg gcctcttgca caagtgtgag tgaggagaaa gactggaagc
     5041 agctgctgtt gctaccacca cccagatctc gccatcacgt gcccgaggca gggggaggca
     5101 cagattgtcc gtgggaggga gtcagtgtct gggaatgggg taggcagctt ccattaaggt
     5161 cctttttcct caccagcagt gggatatttg gaacagaaag aacctcctgc tttctgccca
     5221 agaatgtgtg tgtataggat aattctgtga catagtgtac cattgcctca taccagctgt
     5281 acatacgtgt acatagcaga agtgaataaa gccccccaca cagtgtc
//
LOCUS       NM_001037650            5037 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus nephrocystin 4 (Nphp4), transcript variant 2,
            mRNA.
ACCESSION   NM_001037650 XM_233698
VERSION     NM_001037650.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5037)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 5037)
  AUTHORS   Borgal,L., Habbig,S., Hatzold,J., Liebau,M.C., Dafinger,C.,
            Sacarea,I., Hammerschmidt,M., Benzing,T. and Schermer,B.
  TITLE     The ciliary protein nephrocystin-4 translocates the canonical Wnt
            regulator Jade-1 to the nucleus to negatively regulate beta-catenin
            signaling
  JOURNAL   J Biol Chem 287 (30), 25370-25380 (2012)
   PUBMED   22654112
REFERENCE   3  (bases 1 to 5037)
  AUTHORS   French,V.M., van de Laar,I.M., Wessels,M.W., Rohe,C.,
            Roos-Hesselink,J.W., Wang,G., Frohn-Mulder,I.M., Severijnen,L.A.,
            de Graaf,B.M., Schot,R., Breedveld,G., Mientjes,E., van
            Tienhoven,M., Jadot,E., Jiang,Z., Verkerk,A., Swagemakers,S.,
            Venselaar,H., Rahimi,Z., Najmabadi,H., Meijers-Heijboer,H., de
            Graaff,E., Helbing,W.A., Willemsen,R., Devriendt,K., Belmont,J.W.,
            Oostra,B.A., Amack,J.D. and Bertoli-Avella,A.M.
  TITLE     NPHP4 variants are associated with pleiotropic heart malformations
  JOURNAL   Circ Res 110 (12), 1564-1574 (2012)
   PUBMED   22550138
REFERENCE   4  (bases 1 to 5037)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 5037)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 5037)
  AUTHORS   Hoefele,J., Wolf,M.T., O'Toole,J.F., Otto,E.A., Schultheiss,U.,
            Deschenes,G., Attanasio,M., Utsch,B., Antignac,C. and
            Hildebrandt,F.
  TITLE     Evidence of oligogenic inheritance in nephronophthisis
  JOURNAL   J Am Soc Nephrol 18 (10), 2789-2795 (2007)
   PUBMED   17855640
REFERENCE   7  (bases 1 to 5037)
  AUTHORS   Arts,H.H., Doherty,D., van Beersum,S.E., Parisi,M.A.,
            Letteboer,S.J., Gorden,N.T., Peters,T.A., Marker,T., Voesenek,K.,
            Kartono,A., Ozyurek,H., Farin,F.M., Kroes,H.Y., Wolfrum,U.,
            Brunner,H.G., Cremers,F.P., Glass,I.A., Knoers,N.V. and Roepman,R.
  TITLE     Mutations in the gene encoding the basal body protein RPGRIP1L, a
            nephrocystin-4 interactor, cause Joubert syndrome
  JOURNAL   Nat Genet 39 (7), 882-888 (2007)
   PUBMED   17558407
REFERENCE   8  (bases 1 to 5037)
  AUTHORS   Hoefele,J., Sudbrak,R., Reinhardt,R., Lehrack,S., Hennig,S.,
            Imm,A., Muerb,U., Utsch,B., Attanasio,M., O'Toole,J.F., Otto,E. and
            Hildebrandt,F.
  TITLE     Mutational analysis of the NPHP4 gene in 250 patients with
            nephronophthisis
  JOURNAL   Hum Mutat 25 (4), 411 (2005)
   PUBMED   15776426
REFERENCE   9  (bases 1 to 5037)
  AUTHORS   Hoefele,J., Otto,E., Felten,H., Kuhn,K., Bley,T.A., Zauner,I.,
            Hildebrandt,F. and Neumann,H.P.
  TITLE     Clinical and histological presentation of 3 siblings with mutations
            in the NPHP4 gene
  JOURNAL   Am J Kidney Dis 43 (2), 358-364 (2004)
   PUBMED   14750102
REFERENCE   10 (bases 1 to 5037)
  AUTHORS   Otto,E., Hoefele,J., Ruf,R., Mueller,A.M., Hiller,K.S., Wolf,M.T.,
            Schuermann,M.J., Becker,A., Birkenhager,R., Sudbrak,R.,
            Hennies,H.C., Nurnberg,P. and Hildebrandt,F.
  TITLE     A gene mutated in nephronophthisis and retinitis pigmentosa encodes
            a novel protein, nephroretinin, conserved in evolution
  JOURNAL   Am J Hum Genet 71 (5), 1161-1167 (2002)
   PUBMED   12205563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473968.1.
            
            On May 30, 2008 this sequence version replaced NM_001037650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5037
                     /gene="Nphp4"
                     /note="nephrocystin 4"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
     exon            1..294
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            295..475
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    323..325
                     /gene="Nphp4"
                     /note="upstream in-frame stop codon"
     CDS             341..4627
                     /gene="Nphp4"
                     /note="isoform a is encoded by transcript variant 2;
                     nephronophthisis 4 (juvenile) homolog"
                     /codon_start=1
                     /product="nephrocystin-4 isoform a"
                     /protein_id="NP_001032739.2"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
                     /translation="MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIK
                     QGILDMLSELECHLRVSLFDVTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHT
                     TLSHPSIVAVIEVVAEGRKRDGALQVLSCGFGILRIFGNKPESPTSAGQDKRLRLYHG
                     TPRALLHPLLQDPIEQNRYMTMMENCSLQYTLKPHPPLEPAFHLLPENFLISGLQQIP
                     GLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLEKFEEELVQLLISDHFREGVG
                     LLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRSASFSRRITASSKSS
                     SGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLSSLACMHMV
                     RWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEEVKQVESGTIQFHF
                     SLSSDALTEHANGPRAGRRSTRKALTSPSGTPALAARDLAAIQDSPVGPGLSLSQLAA
                     SPQSLASQRSFKPPPQPLDGSQSPEGPQLQAGSVLESRISHLEADLSQPPFSVQGTPT
                     VEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDARQQPVEAVNP
                     MDPVRFNPQKEESDCLLGNEIVLQFLAFSRAAQDCPGAPWPQTVYFTFQFYRFPPETT
                     PRLQLVKLDRTGKNGSASLSHILVHINKDGSFDAGSPGFQLRYMVDPGFLKPGEQRWF
                     AQYLAAQTLQVDVWDGDSLLLIGSAGIQMKHLLRQGRPAVQVSHELEVVATEYEQEMM
                     VVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHECEPRARGSNALPPSRSRVISNNG
                     ASFFSGGSLLIPGGPKRKRVVQAQKLADVDSELAAMLLTHTRAGQGPQAVGQEADAVH
                     RRKLERMRLVRLQEAGGDSDSRRISVLARHSVRAQHSRDLQVIDAYRERTKAENIASV
                     LSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKE
                     ATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHIPFKFQNFSVGPPAPTQAPAEVISEK
                     DAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFL
                     KKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLGEPRDVFLKVASGP
                     SPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLRGTQTVRK
                     VRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVAS
                     WLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKE
                     DSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDQDDKNEETFCVKVLYQ"
     misc_feature    503..4600
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     misc_feature    503..4600
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     exon            476..628
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            629..801
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            802..866
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1022
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1159
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1341
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1468
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1651
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1778
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1840
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1957
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2109
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2301
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2489
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2650
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2831
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2957
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3163
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3390
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3577
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3661
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3818
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3904
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..3990
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4162
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4342
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4486
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..5037
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgccagc tgaagttcgg ctgctgggat tccttcggtt agtctactga ccctgtgtgc
       61 gcagccgtcc ggggctgaaa ccgatgctgt gagctcgcca gagccttgaa gatgctcaca
      121 gtctggtgta cgcgcctcta tcccagccct aggccgtgca gctctcttag gcccctgcgg
      181 ccctcgatgc actgtgaggc ccttggccca gtccaagtcc agccctcggg gcgcagggct
      241 gacctcctcc tccactgctc ggaattgcaa cccacactgc tgtccgggtt cccaatggtg
      301 cagggagtcc cggagaccca cgtgaggttg gacaggcagc atggatgact ggcacagagc
      361 cttcacccag aacacactgg tccctcccca cccgcagaga gcgcggcagt ttgggaagga
      421 gtccacggcg ttccagtgca tcctgaagtg gcttgatggg ccactcatta agcagggaat
      481 cctagacatg ctgtctgagc ttgaatgcca cctgcgagtg tctctcttcg acgtcaccta
      541 caaacatttc ttcgggagga cgtggaaaac cacagtgaag cccaccaatc agctctctaa
      601 gcagccaccc aggatcctct tcaatgagcc cttgtacttc cacacaacct tgagccaccc
      661 cagcatcgtg gctgtaatag aagtggtcgc tgaaggcagg aagagggacg gtgccctgca
      721 ggtgctgtcc tgtgggtttg gaattcttcg aatttttggc aataagccgg aatctcccac
      781 ctctgcaggc caggacaaac ggttgaggct gtatcatggt acccccagag cccttctgca
      841 cccacttctc caggatccca tagaacagaa caggtacatg acaatgatgg aaaactgtag
      901 cctgcagtat accctgaagc cacacccgcc cctggagccc gccttccacc tgctccccga
      961 gaacttcctg atctccggtc tccagcagat ccctggcctc ctcccacctc atggagacac
     1021 gggtgatgcc ctgaggaagc ctcgcttcca gaagcccacc acattgcacc tagatgacct
     1081 cttcttcacc ctgtacccct ccctggagaa gtttgaggag gaacttgtgc agctgctcat
     1141 cagcgaccac ttccgggagg gggttggcct gctagatagc ggcaccctag aggtcttgga
     1201 gcggcgcctg catgtctgtg tccacaacgg tctgggcttc gtgcacaggc cacaggtggt
     1261 tgtgcttgta cctgagatgg acatgacctt gacgcgctcg gccagcttca gcaggagaat
     1321 cactgcctct tctaagagca gctctggaaa tcaggctctg gttttgagaa gccacctgag
     1381 actcccggag atggtcaatc acccatcgtt tgccatcgtc ttccagctgg agtacgtgtt
     1441 caacagcccc tcaggagcgg acggcagtgc cagctcatcc acctctctgt ccagcttggc
     1501 gtgcatgcac atggttcgat gggctgtttg gaaccccgat ctggaagcag gcccgggaaa
     1561 ggtgacgctg cctcttcagg gtggggtaca gcacaacccc tcacgatgtc tggtctataa
     1621 ggtgccttcg gctagcatga gctctgagga ggtgaagcag gtggaatccg gaaccatcca
     1681 gttccacttc tcactgagct cagatgccct tacagagcat gccaacggcc ccagggcagg
     1741 gcggcgctcc accagaaagg cactaacgtc cccttcaggc acaccagcac tggcagcccg
     1801 ggatcttgct gcgatacagg actctcctgt gggcccaggg ctctcgctct cccagctggc
     1861 ggcctcccca cagtctctgg cctcacaaag atctttcaag cctcctcctc agcccctgga
     1921 tggctctcag tccccagagg gtccccagct ccaagcagga tctgtattag agagcaggat
     1981 ctctcatctg gaagctgacc tgagccagcc gcccttctcg gtgcagggga cgcccactgt
     2041 agaacaccta caggaacttc ccttcactcc tttgcatgcc cccattgtgg tgggagccca
     2101 gaccaggagc tccagaagcc agctctccag agctgccatg gtcctcctgc agtcttccgg
     2161 cttccctgag atccttgatg ccaggcagca gccggtggag gccgtcaatc ccatggatcc
     2221 tgtgaggttc aaccctcaga aggaggagtc agactgcctt ctagggaatg agatcgtgct
     2281 gcagtttctt gccttcagca gagcggccca ggactgcccg ggagcgccgt ggccacagac
     2341 tgtgtatttc accttccagt tctaccgttt cccacccgag accacgccac gcctgcagct
     2401 ggtcaaactg gacaggacag gcaagaacgg ctctgcctcc ctgtctcaca tcctggtcca
     2461 catcaataaa gacggctcct ttgacgctgg ctcccctggc ttccagctga ggtacatggt
     2521 ggatcccggg ttcctgaagc caggagagca gcgctggttc gcccagtacc tggccgctca
     2581 gacgctgcaa gtcgacgtct gggatggaga ctccttgctc ctcattgggt ctgccggcat
     2641 ccagatgaag cacctcctcc gccaagggcg gccagctgtt caggtctcac atgaactgga
     2701 ggtcgtggcc actgagtacg aacaggaaat gatggtggtg agcggcgacg tggcgggctt
     2761 cggcagcgtc aagcccatcg gagtccacac ggtcgtgaag ggccggctgc acctgacctt
     2821 ggccaacgtg ggtcacgagt gtgaaccgag agcaagaggt tccaacgcgc tgccaccatc
     2881 caggtcccgg gtcatctcaa ataatggagc cagcttcttc tctgggggaa gcctcctcat
     2941 accaggaggc cccaagcgaa agcgtgtggt tcaagcccag aagctggctg atgtggacag
     3001 tgagctggcc gccatgctgc tgacccacac tcgagctggc caggggcccc aggctgtggg
     3061 ccaggaggca gacgctgtgc acaggcgcaa gctggaaagg atgcggctgg tgcgcctgca
     3121 ggaggccgga ggggactctg acagtcgcag gatcagcgtg ctggcccgac acagtgtccg
     3181 tgcacagcac tcacgggacc tgcaggtcat cgacgcctac cgggaacgga ccaaggctga
     3241 gaacattgcc agcgtgttga gccaggccat caccacacac cacacactgt atgccacgct
     3301 gggcacggct gagttcttcg agtttgcact taaaaaccca cacaacactc agcacacggt
     3361 ggccatcgag attgacagcc ctgagctcag catcatcctg gacagccagg agtggaggta
     3421 cttcaaggag gccactggcc tgctcacacc cctggaggag gacatgttcc acctgcgtgg
     3481 gagcctggca ccccagctct acctgcggcc ccgggagact gcccacatcc ccttcaagtt
     3541 ccagaacttc tctgtgggcc cacctgctcc gacacaggcc cctgcggagg tgatctcaga
     3601 gaaggatgca gagtctggac cccattggaa gtgcagtgcc atgcctacca aacacgccaa
     3661 ggtccttttc cgggtggaga ccggccagct cattgctgtg ctctgcctga ccgtggagcc
     3721 ccagccccac gtggtggacc aggttttccg tttctaccac ccagaactca ccttcctgaa
     3781 gaaggccatc cgcctgccgc cctggcacac gcttccaggt gctcccgtgg ggatgcctgg
     3841 cgaggacccc ccagtccacg ttcgatgcag cgacccgaat gtcatctgcg aggcccagaa
     3901 cgtgggcctt ggtgagccga gggacgtgtt ccttaaggtg gccagcggtc caagcccgga
     3961 gatcaaagac ttctttgtcg tcatctatgc ggatcgctgg ctggcggtgc ccgtgcagac
     4021 atggcaggtc tgcctccact ccctgcagcg cgtggatgtc tcctgtgtcg cagggcagat
     4081 gacccgtctg tccctcgtcc tacgggggac gcagaccgtt aggaaagtga gagctttcac
     4141 ctcccaccct caggagctga agacagaccc cgctggtgtc tttgtgttac cacctcacgg
     4201 ggtgcaggac ctgcatgtgg gcgtgaggcc aaggagggcg ggcagccgct tcatccatct
     4261 caacctggtg gacgtcgact accaccagct ggtcgcgtcg tggctcgtgt gcctgtcctg
     4321 ccgccagccc ctcatttcca aggccttcga gatcaccatg gcagcaggcg aagggaaggg
     4381 tgccaacaag cggatcacct acaccaaccc ctacccttct cggaggacct accgtctgca
     4441 cagtgaccgg ccagacctgc tgcatttcaa ggaggactcc ttccaggtgg ccggagggga
     4501 gacctacacc atcgggctgc ggttcttgcc gagtggcagc gccgggcagg aggagatcct
     4561 gatctacatc aatgaccagg acgacaagaa tgaagagaca ttctgtgtga aggtcctcta
     4621 ccagtgaggg gatggctgtg aggccagcgc cccttccaga gtgcccctcc ctgcagacat
     4681 cactgtgact ccaggactgg tctgcgtagc ccatggagct gactgagtgc agggagacaa
     4741 aggctaccct cgccatggtg tagcataatc ccatgagcga atgtgacctc cggggtcacg
     4801 gcagtggctc actctgccta tggcactcac aaggttgtgt cacaccccat gactctcagg
     4861 ctgtcaccgt ctagaacaaa ctgttttata aatcatttcc aatgacaaaa ttatgttttt
     4921 ctttctagat ttttaaaaaa tgaacacaat atattttcat ttgctatgta ttttatactg
     4981 gaattccctt gtatatatat tttttaagtt attgaatgaa gcacctcact tcggctg
//
LOCUS       NM_001436876            2979 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus splA/ryanodine receptor domain and SOCS box
            containing 1 (Spsb1), transcript variant 1, mRNA.
ACCESSION   NM_001436876 XM_006239462
VERSION     NM_001436876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Nishiya,T., Matsumoto,K., Maekawa,S., Kajita,E., Horinouchi,T.,
            Fujimuro,M., Ogasawara,K., Uehara,T. and Miwa,S.
  TITLE     Regulation of inducible nitric-oxide synthase by the SPRY domain-
            and SOCS box-containing proteins
  JOURNAL   J Biol Chem 286 (11), 9009-9019 (2011)
   PUBMED   21199876
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006239462.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.23870.1,
                                           SRR26643288.24897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840113 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000005.1  165701281-165701445 c
            166-1007            JAXUCZ010000005.1  165650886-165651727 c
            1008-2979           JAXUCZ010000005.1  165641255-165643226 c
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2979
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
     exon            1..165
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     exon            166..1007
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    290..292
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="upstream in-frame stop codon"
     CDS             314..1135
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 1"
                     /protein_id="NP_001423805.1"
                     /db_xref="GeneID:313722"
                     /db_xref="RGD:1309319"
                     /translation="MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMP
                     PVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQI
                     TWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKT
                     YPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWG
                     HCEIRMRYVNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ"
     misc_feature    473..994
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    473..994
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SPRY domain in the suppressor of cytokine signaling
                     1, 2, 4 families (SOCS1, SOCS2, SOCS4); Region:
                     SPRY_SOCS1-2-4; cd12906"
                     /db_xref="CDD:293963"
     misc_feature    order(542..544,548..550,644..646,698..700,959..967)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    order(542..544,548..550,644..646,698..700,959..967)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293963"
     misc_feature    1007..1132
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    1007..1132
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    order(1010..1027,1043..1045,1073..1075,1091..1093)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     misc_feature    order(1010..1027,1043..1045,1073..1075,1091..1093)
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     exon            1008..2979
                     /gene="Spsb1"
                     /gene_synonym="RGD1309319"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgcacgag tcgcgctgga gcggcccgcg cgcttgccgc aggaaccagc tccaggcgct
       61 ggcgccgggg ccgcggagag gaagcgactt cgctctctgc agcgggcgcg gccctgggca
      121 ccgcgagcct cctgagctcc cggagctgcg gcctctctgt gcgcggcaat acagagcgct
      181 tcacaacctt tggaaatcgc ctagcaacct cccttagggg ttctgtgtgg ccctgactag
      241 aaatctggaa tcaacgcccc aagattgatg agtttgcctt gggagtcagt gaaaaggtga
      301 aagaaaggcc aacatgggtc aaaaggtgac gggagggatc aagactgtgg acatgcggga
      361 ccccacatac cgacctctaa agcaggagct ccagggtttg gattattgca agcccacccg
      421 gctggacctg ctgctcgaca tgccccccgt gtcctacgat gtccagctgc tccactcctg
      481 gaacaacaat gaccgttcgc tcaacgtctt tgtgaaggaa gatgacaagt tgatctttca
      541 ccggcatccg gtggcccaga gcacggacgc catcaggggc aaagttgggt acacacgtgg
      601 actacacgta tggcagatca catgggccat gaggcaacga ggcacgcatg ccgtggtggg
      661 ggtggccaca gcagacgccc ctttgcattc tgttgggtac acaacccttg taggaaataa
      721 ccatgaatcc tggggctggg acctggggcg taaccgtctc taccacgacg gcaagaacca
      781 gccaagtaaa acatacccag ccttcctgga gccagatgag actttcattg tcccagactc
      841 cttccttgtg gccctggaca tggatgatgg gaccttgagt ttcatcgtgg atggacagta
      901 catgggagtg gctttccggg gactcaaggg taaaaagctg tatcctgtag tgagtgccgt
      961 ctggggccac tgtgagatcc gcatgcgcta cgtgaacgga cttgatcctg agcccctgcc
     1021 actcatggac ctgtgccggc gttcggtgcg cctagcgcta ggaaaggaac gtctgggtgc
     1081 catccccgct ctgccgctac ctgcctccct caaagcctac ctcctctacc agtgatccgc
     1141 atcccaggat cgccgtatga cagccacctg gtgccaactc actgagcctt tggggtccac
     1201 cgacccctgc gcctgggatg gacgcccacc ctcaggcatg ggcagacgta ccctctcatc
     1261 ccaccagctg cctctgctgg gtggaccaat gccaacggac ttctcccttc ccaacactgg
     1321 ctgaagcagc agcatccagg cccttccctg aaccagatgc agagaataaa ctatgagaac
     1381 ctctctcagg cgcctctgct ctccagtgga gtgggctgcc cccccactac tccctgaaga
     1441 gagagtctac agccacctgg gggggttcct gggaggtgag acgagtggga gatgccgggg
     1501 cagatcccaa aagcaggaat atgcaggacc aggccacacc gatgaagctc aggatgtcac
     1561 ataccatgga cactgagaca gaaccccagg ctggacctcc ctcgggccag ctctagtgtc
     1621 agctgccggt gctccgtgcc ctgtatttat tctttaaaca gtagcaaagg ccgtttattt
     1681 attccactga gaaaggaaac cttgttgggt ggcttccctc gatgtgctct gttgctttcc
     1741 ccccacctgc cacctccctg gaatgtgtgt gccacacccg tccttctcct ggggccaggc
     1801 ctgtggcacg tgagctggtg tgcacagata caagtatgtc attgtgtacg acctttgacc
     1861 ccgttcccaa gtagctctgc gccaagcacc agagcagaac ctgagtcccc aggtacctgc
     1921 tcctgttacc tggagcgtcc atacaccatc acacgtgttt tgatctctcg tcttccgtgt
     1981 gctttgaatt ttgccccccc ccaatttttc tgatatttcc tgttgaatcc tccaaagttc
     2041 tagacctgga ggaccatcgg gacaccgggg gtgaggggag gggtctccag cccctgggaa
     2101 agccacaggc aaggcaggat tagaccttgt ctcacacaca caccctcaag cctcagcagt
     2161 ggctgtaggg tggacaggac gggtgcctgt ctcctgcagc acaccaatgg agcaccactg
     2221 ctccggctct ctgggcatgt ggtcggttgg gagagggctt gcctagcacg caggaagctc
     2281 aggttccatc ccctgcacca aggagaatca aagctcagga ggctgaggca gggggattgc
     2341 tgttcagtgc tgtacagagg tcgtggacat cccgggctgt attaaatctt gtcctttaag
     2401 aaaaaaagaa aagaaaccaa cttccatcga atctgagttc tgttcatttc tgcacaggta
     2461 cagtagatga ctttatttgt tgaaaatgtt taatatattt acatagatat atttgtaaga
     2521 atcattttaa gcagctgctg tagggtacct tttttaaaaa ataaataaac atcttccagt
     2581 agagtataat ttttaaggca cagaggtggt gccgagacta gataaagaat ctaagtcatt
     2641 ccctctgcgt tttgaggtcc ttctcctttt ttgggagggg ggccttttgt cagacagaaa
     2701 tcttactcgt tctggttttg gagcggatca cattcagccg catagatccc agcttgatct
     2761 ccacccggcc gtaccctcac ggatgctggc gaacagcaag gctctcctgt gtcccccata
     2821 ctccgccgcc ccaggactca ccacacctcc ctgccgtccc ggcaccatca ccgtaaagcc
     2881 ttgtggcatg tatagttctg aaatccccgt tctgttctgt tttatgatga ctcatatcag
     2941 tcagtaacct aataaaggaa agtttgttaa aatatgaaa
//
LOCUS       NM_001436893            1938 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 53, member A
            (Fam53a), mRNA.
ACCESSION   NM_001436893 XM_006251262
VERSION     NM_001436893.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006251262.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35209.1,
                                           SRR26643288.52204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000014.1  81315414-81315649
            237-362             JAXUCZ010000014.1  81316037-81316162
            363-595             JAXUCZ010000014.1  81330648-81330880
            596-650             JAXUCZ010000014.1  81335761-81335815
            651-1414            JAXUCZ010000014.1  81338425-81339188
            1415-1938           JAXUCZ010000014.1  81348407-81348930
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1938
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="family with sequence similarity 53, member A"
                     /db_xref="GeneID:305461"
                     /db_xref="RGD:1563315"
     exon            1..236
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            237..362
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            363..595
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    500..502
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="upstream in-frame stop codon"
     CDS             518..1726
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /codon_start=1
                     /product="protein FAM53A"
                     /protein_id="NP_001423822.1"
                     /db_xref="GeneID:305461"
                     /db_xref="RGD:1563315"
                     /translation="MVTLITEKLQNQSLDDLTRRACEAVPYSAEKLDKSGHLFPLEIG
                     VDKSPWKASHGGWPFRSRAASGPFSVGPHGVSHTEGLKWQLESPGPMAVGRFLDLRES
                     TGPPAAPPTKRHCRSLSEPEELARCRSPWRPGSSKVWTPISKRRCNSGGSATLQCCSG
                     LGNPALQGSLAPGLPRKPVSPTGPTSPMTPRPASASSGFVDGSEGSTSSGPPWLSTGP
                     CPFSSRRRLSLSQEHLVDAGACLPSASSTPTSTPELGRHHGLLRCRSQPCVLDGRRVR
                     RKRRREEDARWTRPSLDFLKMTRTLKNSKSLCSLDYEDDEDDTQAKTVVSSPCNSQGL
                     VGIITPSSSPRIPRPGPASPSVWASGEPETSTGEGGSSGEPSDWDSAGEEGIFPLDHG
                     DLDLEQIENN"
     misc_feature    518..1414
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="Family of FAM53; Region: FAM53; pfam15242"
                     /db_xref="CDD:464582"
     misc_feature    518..1414
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /note="Family of FAM53; Region: FAM53; pfam15242"
                     /db_xref="CDD:464582"
     exon            596..650
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1414
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1938
                     /gene="Fam53a"
                     /gene_synonym="RGD1563315"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcggag cgcggcctgc gcggccggcg ccttgcccca gctacggagc ccggtgctca
       61 cccgtcgcgc ggacattgct ctgtgccgtc gttcgcctgc ccatcgctaa gagctccatc
      121 caccggaacg ccgtgtcctt gcgctgtaag cccggaatct ccgtacgtcg gccggcgccg
      181 cgcagccgca cgtcgagagc cgggtgcatc gccacagcgc gcggaacacc ctctaggaag
      241 caggaagttt gacgagatat gatggtccct taagagaatc ccaagagcag atcctccccg
      301 acgtcctgtg gaaggtgact tggaagtgta ttccgaagcc acttttctgc gtagactgaa
      361 ggtgacaaag ccctgaagag tctgcaaatg ggtcagcatc tttaagtcag agctataacc
      421 ctgagctttg gctcagacct gatggcttga gcctgctgat gtccaggctt ctggaaatcc
      481 agtgcccata gatgtggact aaggaagagc cccgaccatg gtcactctca tcacggagaa
      541 gctgcagaac cagagtttgg atgaccttac ccgaagggcc tgtgaggctg tcccgtattc
      601 tgctgagaaa ctggacaaaa gtggccattt gttccctttg gagattggcg tggataaaag
      661 tccctggaag gcctcacatg gaggatggcc ctttcgaagc cgggcagcct caggcccctt
      721 ctcagtgggc ccacatggtg tgtctcatac cgaaggtctc aagtggcagc tggaatcccc
      781 agggcccatg gctgtgggcc gcttcctgga cctccgtgag agcacagggc cacccgcagc
      841 tccaccaacc aagcgacact gccggtccct gtcagagcca gaggagctgg ctcgatgccg
      901 ttccccatgg cgccctggta gctccaaggt gtggactccc atctctaaga ggagatgcaa
      961 cagtggcggg agtgccacgc tgcagtgctg cagtggtctc ggcaaccctg cactgcaggg
     1021 cagtctagcc cccggcctac ccaggaagcc tgtgtcgccc accggcccta cctcaccgat
     1081 gacgccccgg ccagcttcag ccagcagtgg ctttgtggat ggcagtgagg gcagtacgag
     1141 ctcaggtcca ccctggcttt ctacaggacc ctgcccattt tcctccaggc gccgactgtc
     1201 cctctcacaa gagcaccttg tagatgcagg tgcctgcctg ccttccgcca gcagcacccc
     1261 cacttccaca cctgagctag gccggcacca tggcctgctc cggtgccgct cacagccttg
     1321 tgtgttggat gggaggaggg ttcggcgcaa gcggagacgg gaggaggatg ccaggtggac
     1381 gcgcccatcc ttggactttc tgaaaatgac tcggacttta aaaaactcaa agagcctttg
     1441 ttccctggac tatgaagatg atgaggatga cacccaggcg aagacggttg tgtcctctcc
     1501 gtgtaactcg cagggcctcg tgggcatcat cactcccagc tctagcccaa ggattcccag
     1561 gcctggccct gccagcccca gtgtctgggc ttcaggggag ccagagacta gcaccggtga
     1621 gggtgggagc agtggggaac ccagtgactg ggacagtgca ggagaggagg gcattttccc
     1681 gctggaccac ggcgacctgg acttggagca gattgagaac aactgatttt ggctgagcag
     1741 tggctgctgt ctgtcacctt ggtgcctgac cagtggaaag aacttgtgtg ttattttgaa
     1801 aattgaggtg taattttgat tcagtttttc ctaaagaagt attttgcatt tttatggctt
     1861 ctacagtttg ggagagcatc tctattttga aatgggtttt tagagggcat tctattaaac
     1921 atggttctac gtacattc
//
LOCUS       NM_001436864            2699 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 17
            (Zbtb17), transcript variant 4, mRNA.
ACCESSION   NM_001436864 XM_006239303
VERSION     NM_001436864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Wanzel,M., Russ,A.C., Kleine-Kohlbrecher,D., Colombo,E.,
            Pelicci,P.G. and Eilers,M.
  TITLE     A ribosomal protein L23-nucleophosmin circuit coordinates Mizl
            function with cell growth
  JOURNAL   Nat Cell Biol 10 (9), 1051-1061 (2008)
   PUBMED   19160485
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Adhikary,S., Peukert,K., Karsunky,H., Beuger,V., Lutz,W.,
            Elsasser,H.P., Moroy,T. and Eilers,M.
  TITLE     Miz1 is required for early embryonic development during
            gastrulation
  JOURNAL   Mol Cell Biol 23 (21), 7648-7657 (2003)
   PUBMED   14560010
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Piluso,D., Bilan,P. and Capone,J.P.
  TITLE     Host cell factor-1 interacts with and antagonizes transactivation
            by the cell cycle regulatory factor Miz-1
  JOURNAL   J Biol Chem 277 (48), 46799-46808 (2002)
   PUBMED   12244100
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Peukert,K., Staller,P., Schneider,A., Carmichael,G., Hanel,F. and
            Eilers,M.
  TITLE     An alternative pathway for gene regulation by Myc
  JOURNAL   EMBO J 16 (18), 5672-5686 (1997)
   PUBMED   9312026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006239303.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20947.1,
                                           SRR26643295.23596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000005.1  159036531-159036649
            120-205             JAXUCZ010000005.1  159039108-159039193
            206-412             JAXUCZ010000005.1  159052105-159052311
            413-601             JAXUCZ010000005.1  159052950-159053138
            602-742             JAXUCZ010000005.1  159053664-159053804
            743-865             JAXUCZ010000005.1  159054043-159054165
            866-1107            JAXUCZ010000005.1  159054558-159054799
            1108-1250           JAXUCZ010000005.1  159054883-159055025
            1251-1551           JAXUCZ010000005.1  159055113-159055413
            1552-1639           JAXUCZ010000005.1  159055678-159055765
            1640-1756           JAXUCZ010000005.1  159055850-159055966
            1757-1877           JAXUCZ010000005.1  159056048-159056168
            1878-2008           JAXUCZ010000005.1  159056301-159056431
            2009-2218           JAXUCZ010000005.1  159056701-159056910
            2219-2308           JAXUCZ010000005.1  159057023-159057112
            2309-2699           JAXUCZ010000005.1  159057190-159057580
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2699
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="zinc finger and BTB domain containing 17"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
     exon            1..119
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            120..205
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="upstream in-frame stop codon"
     exon            206..412
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2592
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="isoform c is encoded by transcript variant 4; zinc
                     finger protein 100; zinc finger and BTB domain-containing
                     protein 17"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 17
                     isoform c"
                     /protein_id="NP_001423793.1"
                     /db_xref="GeneID:313666"
                     /db_xref="RGD:1307143"
                     /translation="MDFPQHSQRVLEQLNQQRQMGLLCDCTFVVDGVDFKAHKAVLAA
                     CSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLHLSPENVDDVLAVASFLQMQ
                     DIITACHTLKSLAEPTSTTGESADASAEEGGDKRAKEEKAAATVLSRLDQARSSSSAG
                     PGRELKEEWGGQAESASRGAEQTEKADAPREPPPVELKPDPTSSMAAAEAEALSESSE
                     QEMEVEPASKGEEGQEEEGPGPATVKEEGVHLENGEPPEENEESAGTDSGHELGMEGQ
                     NLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAF
                     SDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTT
                     SGNLKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG
                     NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGAL
                     QRHVRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLAN
                     HIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHV
                     KTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADE
                     TEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQT
                     DADFYQQYGPGGAWPAGQMLQAGELVFRPRDGTEGQPTLAETPPTAPDCLPPAE"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    211..546
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 17 (ZBTB17); Region:
                     BTB_POZ_ZBTB17_MIZ1; cd18206"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(214..219,223..240,244..249,256..258,271..276,
                     319..321,325..327,334..342,355..357,433..438,445..456,
                     514..516)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    order(268..270,277..303,307..309,313..315,322..324,
                     382..387,391..396,400..402)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative tetramer (dimer of dimer) interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:349515"
     misc_feature    1096..2091
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1096..2091
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1102..1164
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1102..1164
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1186..1248
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1186..1248
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1270..1332
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1270..1332
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1285..1287,1291..1293,1297..1299,1303..1308,
                     1315..1320,1327..1329,1369..1371,1375..1377,1387..1392,
                     1399..1404,1411..1413,1453..1455,1459..1461,1465..1467,
                     1471..1476,1483..1488,1495..1497)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1285..1287,1291..1293,1297..1299,1303..1308,
                     1315..1320,1327..1329,1369..1371,1375..1377,1387..1392,
                     1399..1404,1411..1413,1453..1455,1459..1461,1465..1467,
                     1471..1476,1483..1488,1495..1497)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1354..1416
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1354..1416
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1438..1500
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1438..1500
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1522..1584
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1522..1584
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1606..1668
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1606..1668
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1621..1623,1627..1629,1633..1635,1639..1644,
                     1651..1656,1663..1665,1705..1707,1711..1713,1723..1728,
                     1735..1740,1747..1749,1789..1791,1795..1797,1801..1803,
                     1807..1812,1819..1824,1831..1833)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1621..1623,1627..1629,1633..1635,1639..1644,
                     1651..1656,1663..1665,1705..1707,1711..1713,1723..1728,
                     1735..1740,1747..1749,1789..1791,1795..1797,1801..1803,
                     1807..1812,1819..1824,1831..1833)
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1690..1752
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1690..1752
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1774..1836
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1774..1836
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1858..1920
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1858..1920
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1942..2004
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1942..2004
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2026..2085
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2026..2085
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     exon            413..601
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            602..742
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            743..865
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1107
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1250
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1551
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1639
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1756
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1877
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2008
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2218
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2308
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2699
                     /gene="Zbtb17"
                     /gene_synonym="Zfp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccgtt ccgcccgact ctaacatggc ggcgcccttt gtctactgtg aagcgctgcc
       61 cccggccttc tcgcggccgt gatgcacctc catctgtggt ggggttcggg acatggcagg
      121 tgatgagctg gaggaagaga gccgagctgg agttctacag gcacactgtc tgagaagaga
      181 gcccccggct ttttggagat ctgagccatg gacttccccc agcacagcca gcgtgtcttg
      241 gagcagctga accagcagcg gcaaatgggc ctcctctgtg actgcacctt tgtggtggac
      301 ggcgttgact tcaaagctca caaggcggtg ctggcagcct gcagcgagta cttcaagatg
      361 ctctttgtgg accagaagga tgtggtgcac ctggacatca gtaatgcggc aggcctgggg
      421 caggtgctgg agttcatgta cactgctaaa ctgcacctta gccctgagaa cgtggatgat
      481 gttctggctg tggccagctt cctccagatg caggacatta tcacagcctg ccacaccctg
      541 aagtccctcg ctgagcccac cagcaccact ggggagagtg cagacgcctc ggccgaggaa
      601 ggaggagaca agcgagccaa agaagagaag gctgccgcca ccgtgctgag caggctggac
      661 caagcaagaa gcagttcatc cgcaggccca ggcagagagc tcaaagagga gtggggtggt
      721 caggcagaga gtgcatccag gggcgcagaa cagacggaga aggccgacgc gccccgggag
      781 cctccacctg tggagctcaa gccggacccc acgagcagca tggctgctgc agaagcggaa
      841 gccttatcag agagctcaga gcaagaaatg gaagtggaac cagccagcaa aggagaagag
      901 ggccaagagg aagagggccc agggcctgcc acggtcaagg aagagggcgt tcacctggag
      961 aacggggagc ctcctgagga gaatgaagag tctgcgggca cagactctgg gcacgagctt
     1021 ggcatggagg gccagaacct gcgctcgggc acctacgggg accgcactga gtccaaggct
     1081 tatggctcca tcatccacaa gtgcgaggac tgcgggaagg agttcacgca cacagggaac
     1141 ttcaaacggc acatccgcat ccacacgggt gagaagccat tctcctgtcg ggagtgcagc
     1201 aaggctttct cggaccccgc agcctgcaag gctcacgaga agacacacag cccgttgaaa
     1261 ccctatgggt gcgaggagtg cggcaagagc tacaggctca tcagcctgct gaacctgcac
     1321 aagaagaggc actcggggga ggcgcgctac cgctgcgggg actgcggcaa gctcttcacc
     1381 acttccggca acctcaagcg ccaccagctg gtacacagtg gccagaaacc ctaccagtgc
     1441 gactactgtg gccgttcatt ctccgacccc acgtccaaga tgcgccacct ggagacccat
     1501 gacactgaca aggagcacaa gtgccctcac tgtgacaaga agttcaacca ggtggggaac
     1561 ctgaaggccc acttgaagat ccacattgct gacggccctc tcaagtgccg ggagtgcggg
     1621 aagcaattca ccacctcagg gaacctcaag cggcacctgc ggatccacag cggggagaag
     1681 ccgtatgtat gcacccactg tcagcggcag tttgctgacc caggcgcgct gcagcggcac
     1741 gtacggatcc acacgggtga gaagccgtgt cagtgcgtga tatgtggcaa ggccttcacc
     1801 caagccagct ccctcatcgc ccacgtacgc cagcacacgg gggagaagcc ctatgtctgt
     1861 gaacgctgtg gcaagagatt tgtccagtca agccagttgg ccaatcacat tcgtcaccat
     1921 gacaacatcc gcccacacaa gtgcagcgtg tgtagcaagg ccttcgtgaa tgtgggggac
     1981 ctgtccaagc acattatcat ccacactgga gagaagcctt acttatgtga caagtgtggc
     2041 cgtggtttca accgggtaga caacctgcgt tctcacgtaa agaccgtgca tcagggcaag
     2101 gcgggcatca agatcctgga gccagaagag ggtggtgagg tcagcgtggt cactgtggac
     2161 gacatggtca cactggccac tgaggcactg gcagcgacag cggtcactca gctcacagtg
     2221 gtaccagtcg gggccgcagt gacagctgat gagacggagg ttctcaaagc tgagatcagc
     2281 aaagctgtca agcaagtgca ggaagaagat cccaacaccc acatcctgta tgcgtgtgat
     2341 tcctgtgggg acaagttcct ggatgccaat agcctggccc agcacgttcg gatccacaca
     2401 gcacaggcac tggtcatgtt ccagacggat gcggacttct accagcagta cgggccaggt
     2461 ggcgcgtggc cagccgggca gatgctgcag gctggagagc tggtcttccg tcctagggat
     2521 gggactgagg gccagcccac actggcagaa actccaccca cagctcctga ttgcctacca
     2581 cctgccgagt aagcaggtgg ccctctgact gtttatttaa ggatgggtgg caccccagga
     2641 ctcgaattcc ggtgctcctg ccccattccc tagagagaat aaatttgatt attttctaa
//
LOCUS       NM_001436895            4923 bp    mRNA    linear   ROD 26-MAR-2025
DEFINITION  Rattus norvegicus nephrocystin 4 (Nphp4), transcript variant 1,
            mRNA.
ACCESSION   NM_001436895 XM_039110105
VERSION     NM_001436895.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4923)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 4923)
  AUTHORS   Borgal,L., Habbig,S., Hatzold,J., Liebau,M.C., Dafinger,C.,
            Sacarea,I., Hammerschmidt,M., Benzing,T. and Schermer,B.
  TITLE     The ciliary protein nephrocystin-4 translocates the canonical Wnt
            regulator Jade-1 to the nucleus to negatively regulate beta-catenin
            signaling
  JOURNAL   J Biol Chem 287 (30), 25370-25380 (2012)
   PUBMED   22654112
REFERENCE   3  (bases 1 to 4923)
  AUTHORS   French,V.M., van de Laar,I.M., Wessels,M.W., Rohe,C.,
            Roos-Hesselink,J.W., Wang,G., Frohn-Mulder,I.M., Severijnen,L.A.,
            de Graaf,B.M., Schot,R., Breedveld,G., Mientjes,E., van
            Tienhoven,M., Jadot,E., Jiang,Z., Verkerk,A., Swagemakers,S.,
            Venselaar,H., Rahimi,Z., Najmabadi,H., Meijers-Heijboer,H., de
            Graaff,E., Helbing,W.A., Willemsen,R., Devriendt,K., Belmont,J.W.,
            Oostra,B.A., Amack,J.D. and Bertoli-Avella,A.M.
  TITLE     NPHP4 variants are associated with pleiotropic heart malformations
  JOURNAL   Circ Res 110 (12), 1564-1574 (2012)
   PUBMED   22550138
REFERENCE   4  (bases 1 to 4923)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 4923)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 4923)
  AUTHORS   Hoefele,J., Wolf,M.T., O'Toole,J.F., Otto,E.A., Schultheiss,U.,
            Deschenes,G., Attanasio,M., Utsch,B., Antignac,C. and
            Hildebrandt,F.
  TITLE     Evidence of oligogenic inheritance in nephronophthisis
  JOURNAL   J Am Soc Nephrol 18 (10), 2789-2795 (2007)
   PUBMED   17855640
REFERENCE   7  (bases 1 to 4923)
  AUTHORS   Arts,H.H., Doherty,D., van Beersum,S.E., Parisi,M.A.,
            Letteboer,S.J., Gorden,N.T., Peters,T.A., Marker,T., Voesenek,K.,
            Kartono,A., Ozyurek,H., Farin,F.M., Kroes,H.Y., Wolfrum,U.,
            Brunner,H.G., Cremers,F.P., Glass,I.A., Knoers,N.V. and Roepman,R.
  TITLE     Mutations in the gene encoding the basal body protein RPGRIP1L, a
            nephrocystin-4 interactor, cause Joubert syndrome
  JOURNAL   Nat Genet 39 (7), 882-888 (2007)
   PUBMED   17558407
REFERENCE   8  (bases 1 to 4923)
  AUTHORS   Hoefele,J., Sudbrak,R., Reinhardt,R., Lehrack,S., Hennig,S.,
            Imm,A., Muerb,U., Utsch,B., Attanasio,M., O'Toole,J.F., Otto,E. and
            Hildebrandt,F.
  TITLE     Mutational analysis of the NPHP4 gene in 250 patients with
            nephronophthisis
  JOURNAL   Hum Mutat 25 (4), 411 (2005)
   PUBMED   15776426
REFERENCE   9  (bases 1 to 4923)
  AUTHORS   Hoefele,J., Otto,E., Felten,H., Kuhn,K., Bley,T.A., Zauner,I.,
            Hildebrandt,F. and Neumann,H.P.
  TITLE     Clinical and histological presentation of 3 siblings with mutations
            in the NPHP4 gene
  JOURNAL   Am J Kidney Dis 43 (2), 358-364 (2004)
   PUBMED   14750102
REFERENCE   10 (bases 1 to 4923)
  AUTHORS   Otto,E., Hoefele,J., Ruf,R., Mueller,A.M., Hiller,K.S., Wolf,M.T.,
            Schuermann,M.J., Becker,A., Birkenhager,R., Sudbrak,R.,
            Hennies,H.C., Nurnberg,P. and Hildebrandt,F.
  TITLE     A gene mutated in nephronophthisis and retinitis pigmentosa encodes
            a novel protein, nephroretinin, conserved in evolution
  JOURNAL   Am J Hum Genet 71 (5), 1161-1167 (2002)
   PUBMED   12205563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110105.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.22107.1,
                                           SRR26643298.30540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000005.1  168270670-168270849
            181-361             JAXUCZ010000005.1  168277437-168277617
            362-514             JAXUCZ010000005.1  168282813-168282965
            515-687             JAXUCZ010000005.1  168290128-168290300
            688-752             JAXUCZ010000005.1  168291652-168291716
            753-908             JAXUCZ010000005.1  168292620-168292775
            909-1045            JAXUCZ010000005.1  168297120-168297256
            1046-1227           JAXUCZ010000005.1  168300379-168300560
            1228-1354           JAXUCZ010000005.1  168301228-168301354
            1355-1537           JAXUCZ010000005.1  168309203-168309385
            1538-1664           JAXUCZ010000005.1  168316446-168316572
            1665-1726           JAXUCZ010000005.1  168327502-168327563
            1727-1843           JAXUCZ010000005.1  168329021-168329137
            1844-1995           JAXUCZ010000005.1  168329634-168329785
            1996-2187           JAXUCZ010000005.1  168329859-168330050
            2188-2375           JAXUCZ010000005.1  168330878-168331065
            2376-2536           JAXUCZ010000005.1  168338285-168338445
            2537-2717           JAXUCZ010000005.1  168340719-168340899
            2718-2843           JAXUCZ010000005.1  168344977-168345102
            2844-3049           JAXUCZ010000005.1  168347638-168347843
            3050-3276           JAXUCZ010000005.1  168348775-168349001
            3277-3463           JAXUCZ010000005.1  168349357-168349543
            3464-3547           JAXUCZ010000005.1  168350199-168350282
            3548-3704           JAXUCZ010000005.1  168352301-168352457
            3705-3790           JAXUCZ010000005.1  168352856-168352941
            3791-3876           JAXUCZ010000005.1  168353450-168353535
            3877-4048           JAXUCZ010000005.1  168354298-168354469
            4049-4228           JAXUCZ010000005.1  168354732-168354911
            4229-4372           JAXUCZ010000005.1  168355159-168355302
            4373-4923           JAXUCZ010000005.1  168355843-168356393
FEATURES             Location/Qualifiers
     source          1..4923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4923
                     /gene="Nphp4"
                     /note="nephrocystin 4"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
     exon            1..180
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            181..361
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    209..211
                     /gene="Nphp4"
                     /note="upstream in-frame stop codon"
     CDS             227..4513
                     /gene="Nphp4"
                     /note="isoform a is encoded by transcript variant 1;
                     nephronophthisis 4 (juvenile) homolog"
                     /codon_start=1
                     /product="nephrocystin-4 isoform a"
                     /protein_id="NP_001423824.1"
                     /db_xref="GeneID:313749"
                     /db_xref="RGD:1560172"
                     /translation="MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIK
                     QGILDMLSELECHLRVSLFDVTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHT
                     TLSHPSIVAVIEVVAEGRKRDGALQVLSCGFGILRIFGNKPESPTSAGQDKRLRLYHG
                     TPRALLHPLLQDPIEQNRYMTMMENCSLQYTLKPHPPLEPAFHLLPENFLISGLQQIP
                     GLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLEKFEEELVQLLISDHFREGVG
                     LLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRSASFSRRITASSKSS
                     SGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLSSLACMHMV
                     RWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEEVKQVESGTIQFHF
                     SLSSDALTEHANGPRAGRRSTRKALTSPSGTPALAARDLAAIQDSPVGPGLSLSQLAA
                     SPQSLASQRSFKPPPQPLDGSQSPEGPQLQAGSVLESRISHLEADLSQPPFSVQGTPT
                     VEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDARQQPVEAVNP
                     MDPVRFNPQKEESDCLLGNEIVLQFLAFSRAAQDCPGAPWPQTVYFTFQFYRFPPETT
                     PRLQLVKLDRTGKNGSASLSHILVHINKDGSFDAGSPGFQLRYMVDPGFLKPGEQRWF
                     AQYLAAQTLQVDVWDGDSLLLIGSAGIQMKHLLRQGRPAVQVSHELEVVATEYEQEMM
                     VVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHECEPRARGSNALPPSRSRVISNNG
                     ASFFSGGSLLIPGGPKRKRVVQAQKLADVDSELAAMLLTHTRAGQGPQAVGQEADAVH
                     RRKLERMRLVRLQEAGGDSDSRRISVLARHSVRAQHSRDLQVIDAYRERTKAENIASV
                     LSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKE
                     ATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHIPFKFQNFSVGPPAPTQAPAEVISEK
                     DAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFL
                     KKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLGEPRDVFLKVASGP
                     SPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLRGTQTVRK
                     VRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVAS
                     WLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKE
                     DSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDQDDKNEETFCVKVLYQ"
     misc_feature    389..4486
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     misc_feature    389..4486
                     /gene="Nphp4"
                     /note="Nephrocystin-4; Region: NPHP4; cd22239"
                     /db_xref="CDD:412072"
     exon            362..514
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..687
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..752
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..908
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1045
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1227
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1354
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1537
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1664
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1726
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1843
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1995
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2187
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2375
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2536
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2717
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2843
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3049
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3276
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3463
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3547
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3704
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3790
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3876
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4048
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4049..4228
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4372
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..4923
                     /gene="Nphp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagtgag cggtatccct caggtcggga ctcctcgcgt gggtggcggc ggattgggcg
       61 accccctgga ccagcactgg atccacgaga cctcgggttc cgctgggcac cggcagcccg
      121 atcgctggat ccacggtgcg ggacctgttc cgtagcgtgg atctcgtgcc cgtctcctag
      181 atggtgcagg gagtcccgga gacccacgtg aggttggaca ggcagcatgg atgactggca
      241 cagagccttc acccagaaca cactggtccc tccccacccg cagagagcgc ggcagtttgg
      301 gaaggagtcc acggcgttcc agtgcatcct gaagtggctt gatgggccac tcattaagca
      361 gggaatccta gacatgctgt ctgagcttga atgccacctg cgagtgtctc tcttcgacgt
      421 cacctacaaa catttcttcg ggaggacgtg gaaaaccaca gtgaagccca ccaatcagct
      481 ctctaagcag ccacccagga tcctcttcaa tgagcccttg tacttccaca caaccttgag
      541 ccaccccagc atcgtggctg taatagaagt ggtcgctgaa ggcaggaaga gggacggtgc
      601 cctgcaggtg ctgtcctgtg ggtttggaat tcttcgaatt tttggcaata agccggaatc
      661 tcccacctct gcaggccagg acaaacggtt gaggctgtat catggtaccc ccagagccct
      721 tctgcaccca cttctccagg atcccataga acagaacagg tacatgacaa tgatggaaaa
      781 ctgtagcctg cagtataccc tgaagccaca cccgcccctg gagcccgcct tccacctgct
      841 ccccgagaac ttcctgatct ccggtctcca gcagatccct ggcctcctcc cacctcatgg
      901 agacacgggt gatgccctga ggaagcctcg cttccagaag cccaccacat tgcacctaga
      961 tgacctcttc ttcaccctgt acccctccct ggagaagttt gaggaggaac ttgtgcagct
     1021 gctcatcagc gaccacttcc gggagggggt tggcctgcta gatagcggca ccctagaggt
     1081 cttggagcgg cgcctgcatg tctgtgtcca caacggtctg ggcttcgtgc acaggccaca
     1141 ggtggttgtg cttgtacctg agatggacat gaccttgacg cgctcggcca gcttcagcag
     1201 gagaatcact gcctcttcta agagcagctc tggaaatcag gctctggttt tgagaagcca
     1261 cctgagactc ccggagatgg tcaatcaccc atcgtttgcc atcgtcttcc agctggagta
     1321 cgtgttcaac agcccctcag gagcggacgg cagtgccagc tcatccacct ctctgtccag
     1381 cttggcgtgc atgcacatgg ttcgatgggc tgtttggaac cccgatctgg aagcaggccc
     1441 gggaaaggtg acgctgcctc ttcagggtgg ggtacagcac aacccctcac gatgtctggt
     1501 ctataaggtg ccttcggcta gcatgagctc tgaggaggtg aagcaggtgg aatccggaac
     1561 catccagttc cacttctcac tgagctcaga tgcccttaca gagcatgcca acggccccag
     1621 ggcagggcgg cgctccacca gaaaggcact aacgtcccct tcaggcacac cagcactggc
     1681 agcccgggat cttgctgcga tacaggactc tcctgtgggc ccagggctct cgctctccca
     1741 gctggcggcc tccccacagt ctctggcctc acaaagatct ttcaagcctc ctcctcagcc
     1801 cctggatggc tctcagtccc cagagggtcc ccagctccaa gcaggatctg tattagagag
     1861 caggatctct catctggaag ctgacctgag ccagccgccc ttctcggtgc aggggacgcc
     1921 cactgtagaa cacctacagg aacttccctt cactcctttg catgccccca ttgtggtggg
     1981 agcccagacc aggagctcca gaagccagct ctccagagct gccatggtcc tcctgcagtc
     2041 ttccggcttc cctgagatcc ttgatgccag gcagcagccg gtggaggccg tcaatcccat
     2101 ggatcctgtg aggttcaacc ctcagaagga ggagtcagac tgccttctag ggaatgagat
     2161 cgtgctgcag tttcttgcct tcagcagagc ggcccaggac tgcccgggag cgccgtggcc
     2221 acagactgtg tatttcacct tccagttcta ccgtttccca cccgagacca cgccacgcct
     2281 gcagctggtc aaactggaca ggacaggcaa gaacggctct gcctccctgt ctcacatcct
     2341 ggtccacatc aataaagacg gctcctttga cgctggctcc cctggcttcc agctgaggta
     2401 catggtggat cccgggttcc tgaagccagg agagcagcgc tggttcgccc agtacctggc
     2461 cgctcagacg ctgcaagtcg acgtctggga tggagactcc ttgctcctca ttgggtctgc
     2521 cggcatccag atgaagcacc tcctccgcca agggcggcca gctgttcagg tctcacatga
     2581 actggaggtc gtggccactg agtacgaaca ggaaatgatg gtggtgagcg gcgacgtggc
     2641 gggcttcggc agcgtcaagc ccatcggagt ccacacggtc gtgaagggcc ggctgcacct
     2701 gaccttggcc aacgtgggtc acgagtgtga accgagagca agaggttcca acgcgctgcc
     2761 accatccagg tcccgggtca tctcaaataa tggagccagc ttcttctctg ggggaagcct
     2821 cctcatacca ggaggcccca agcgaaagcg tgtggttcaa gcccagaagc tggctgatgt
     2881 ggacagtgag ctggccgcca tgctgctgac ccacactcga gctggccagg ggccccaggc
     2941 tgtgggccag gaggcagacg ctgtgcacag gcgcaagctg gaaaggatgc ggctggtgcg
     3001 cctgcaggag gccggagggg actctgacag tcgcaggatc agcgtgctgg cccgacacag
     3061 tgtccgtgca cagcactcac gggacctgca ggtcatcgac gcctaccggg aacggaccaa
     3121 ggctgagaac attgccagcg tgttgagcca ggccatcacc acacaccaca cactgtatgc
     3181 cacgctgggc acggctgagt tcttcgagtt tgcacttaaa aacccacaca acactcagca
     3241 cacggtggcc atcgagattg acagccctga gctcagcatc atcctggaca gccaggagtg
     3301 gaggtacttc aaggaggcca ctggcctgct cacacccctg gaggaggaca tgttccacct
     3361 gcgtgggagc ctggcacccc agctctacct gcggccccgg gagactgccc acatcccctt
     3421 caagttccag aacttctctg tgggcccacc tgctccgaca caggcccctg cggaggtgat
     3481 ctcagagaag gatgcagagt ctggacccca ttggaagtgc agtgccatgc ctaccaaaca
     3541 cgccaaggtc cttttccggg tggagaccgg ccagctcatt gctgtgctct gcctgaccgt
     3601 ggagccccag ccccacgtgg tggaccaggt tttccgtttc taccacccag aactcacctt
     3661 cctgaagaag gccatccgcc tgccgccctg gcacacgctt ccaggtgctc ccgtggggat
     3721 gcctggcgag gaccccccag tccacgttcg atgcagcgac ccgaatgtca tctgcgaggc
     3781 ccagaacgtg ggccttggtg agccgaggga cgtgttcctt aaggtggcca gcggtccaag
     3841 cccggagatc aaagacttct ttgtcgtcat ctatgcggat cgctggctgg cggtgcccgt
     3901 gcagacatgg caggtctgcc tccactccct gcagcgcgtg gatgtctcct gtgtcgcagg
     3961 gcagatgacc cgtctgtccc tcgtcctacg ggggacgcag accgttagga aagtgagagc
     4021 tttcacctcc caccctcagg agctgaagac agaccccgct ggtgtctttg tgttaccacc
     4081 tcacggggtg caggacctgc atgtgggcgt gaggccaagg agggcgggca gccgcttcat
     4141 ccatctcaac ctggtggacg tcgactacca ccagctggtc gcgtcgtggc tcgtgtgcct
     4201 gtcctgccgc cagcccctca tttccaaggc cttcgagatc accatggcag caggcgaagg
     4261 gaagggtgcc aacaagcgga tcacctacac caacccctac ccttctcgga ggacctaccg
     4321 tctgcacagt gaccggccag acctgctgca tttcaaggag gactccttcc aggtggccgg
     4381 aggggagacc tacaccatcg ggctgcggtt cttgccgagt ggcagcgccg ggcaggagga
     4441 gatcctgatc tacatcaatg accaggacga caagaatgaa gagacattct gtgtgaaggt
     4501 cctctaccag tgaggggatg gctgtgaggc cagcgcccct tccagagtgc ccctccctgc
     4561 agacatcact gtgactccag gactggtctg cgtagcccat ggagctgact gagtgcaggg
     4621 agacaaaggc taccctcgcc atggtgtagc ataatcccat gagcgaatgt gacctccggg
     4681 gtcacggcag tggctcactc tgcctatggc actcacaagg ttgtgtcaca ccccatgact
     4741 ctcaggctgt caccgtctag aacaaactgt tttataaatc atttccaatg acaaaattat
     4801 gtttttcttt ctagattttt aaaaaatgaa cacaatatat tttcatttgc tatgtatttt
     4861 atactggaat tcccttgtat atatattttt taagttattg aatgaagcac ctcacttcgg
     4921 ctg
//
LOCUS       NM_001437149             932 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 4, mRNA.
ACCESSION   NM_001437149
VERSION     NM_001437149.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.549361.1,
                                           SRR26360190.411716.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  20594710-20594770
            62-167              JAXUCZ010000008.1  20618401-20618506
            168-244             JAXUCZ010000008.1  20627474-20627550
            245-932             JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..932
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..61
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            62..167
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    164..166
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="upstream in-frame stop codon"
     exon            168..244
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            245..932
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..505
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424078.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    326..490
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    326..490
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 agaggcgagg cgggcgagcg gctgcccctg ccacgtaccc ggccgtgcgc ggcggcggca
       61 gggtgtaata acaggccttt ggtgccttgc agtttaactt cccgtcggat ctgctctcag
      121 aaccacacat cgttggggca cagcgcgctt ttgtttcctt ctgtaaggaa gaactcaggt
      181 caccctgact ggaaatcagt tgacccacgt cagtgaagca gtggttcctg aatttgaaga
      241 aaagaggtgg tctgcccgga cagaggagtg tggccctttc ttcaagccct ctctgcacat
      301 ctcttcccag catcctctaa ccaagatgcg tcagctcaaa gggaagccaa agaaagagac
      361 ctccaaggac aagaaggagc ggaagcaggc catgcaggag gcccggcagc agatcaccac
      421 tgtggtgctg cctaccttgg ctgtggtggt gctcctcatt gtagtgtttg tgtacgtggc
      481 cacgcgcccc atcgtcaccg agtgagcacc gccatcctgg ctttcctctg cagacatgtc
      541 tgcaatgccg agctctgggc aggagtgccc tgtctcctct gatctttgac ttgatcaata
      601 tttctctact tttggggggg aagggaaagg gaacatttat cagtgaatgt gccatttacc
      661 cgatggtcca cttcatgtgc ctttcagact tcaaagcagt gcgtgtgtgc gtgtgcgtgt
      721 gcgtgtgtgc gtgcgtgtct ccccttttct cctgaaatcg acgcacagct gcacctgggg
      781 agaggaggcc tctccgggtg acactgtgct tcctggctcc gttcacagct ttctaagggg
      841 acagcctttc ttctctgtac ttgatgggat gtgaaatacg ctgactcaaa gtgaaatatt
      901 tatttttgaa taaaggagat aatagtctta aa
//
LOCUS       NM_001437147             815 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 3, mRNA.
ACCESSION   NM_001437147
VERSION     NM_001437147.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2159867.1,
                                           SRR22582419.1897513.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  20594710-20594770
            62-127              JAXUCZ010000008.1  20627485-20627550
            128-815             JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..815
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..61
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            62..127
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            128..815
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..388
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424076.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    209..373
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    209..373
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 agaggcgagg cgggcgagcg gctgcccctg ccacgtaccc ggccgtgcgc ggcggcggca
       61 ggtcaccctg actggaaatc agttgaccca cgtcagtgaa gcagtggttc ctgaatttga
      121 agaaaagagg tggtctgccc ggacagagga gtgtggccct ttcttcaagc cctctctgca
      181 catctcttcc cagcatcctc taaccaagat gcgtcagctc aaagggaagc caaagaaaga
      241 gacctccaag gacaagaagg agcggaagca ggccatgcag gaggcccggc agcagatcac
      301 cactgtggtg ctgcctacct tggctgtggt ggtgctcctc attgtagtgt ttgtgtacgt
      361 ggccacgcgc cccatcgtca ccgagtgagc accgccatcc tggctttcct ctgcagacat
      421 gtctgcaatg ccgagctctg ggcaggagtg ccctgtctcc tctgatcttt gacttgatca
      481 atatttctct acttttgggg gggaagggaa agggaacatt tatcagtgaa tgtgccattt
      541 acccgatggt ccacttcatg tgcctttcag acttcaaagc agtgcgtgtg tgcgtgtgcg
      601 tgtgcgtgtg tgcgtgcgtg tctccccttt tctcctgaaa tcgacgcaca gctgcacctg
      661 gggagaggag gcctctccgg gtgacactgt gcttcctggc tccgttcaca gctttctaag
      721 gggacagcct ttcttctctg tacttgatgg gatgtgaaat acgctgactc aaagtgaaat
      781 atttattttt gaataaagga gataatagtc ttaaa
//
LOCUS       NM_001437139             719 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 2, mRNA.
ACCESSION   NM_001437139 XM_039084496
VERSION     NM_001437139.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039084496.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3179837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000009.1  21074406-21074500
            96-195              JAXUCZ010000009.1  21079517-21079616
            196-719             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..719
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..95
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            96..195
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    100..102
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="upstream in-frame stop codon"
     CDS             112..546
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Guca1a neighbor"
                     /codon_start=1
                     /product="putative uncharacterized protein CIMIP3 isoform
                     2"
                     /protein_id="NP_001424068.1"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
                     /translation="MDHAVVTTKSGLWSERKRRELEGRVTPKESQKSLIPGHRQKTTS
                     GRKGKKVPPPTPTPLSQKWKRDRKQSLESAYVPVVVDPRGQEPDSSFRFNFYNSQYSN
                     SLNPFYTLQKPTCGYLYQRETDHTRKCFGIPPANLVLWRSTY"
     exon            196..719
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccctcc cgagactccc cagatgcctc tggatcccta accaccagaa gttccatttt
       61 accatcaaag aggaaactga ccaaagatgt tgaaaataat agacacaaaa gatggatcac
      121 gcggttgtca ctaccaaaag tggactttgg agcgaacgga aaaggcgaga gcttgaaggg
      181 agagtgactc cgaaggagtc acagaaatcc ttaatccccg gtcaccggca aaagacgaca
      241 tcaggcagaa aggggaagaa ggtgccgccg cccacaccaa caccattgtc acagaaatgg
      301 aaacgggacc gcaaacagtc tctggagtca gcttatgtcc ccgtggtggt ggatcctcgc
      361 gggcaggagc cagacagtag tttcaggttc aatttctaca actcacagta ttccaactct
      421 ctcaatccct tctacaccct gcagaaaccc acctgtggtt acctgtacca gagagaaact
      481 gaccacacac ggaaatgctt tggcattcct cccgcaaacc tggtcttgtg gcgcagcacc
      541 tactaaatcc aaggcatctg gaagtcccca ccctgcacct tcactctgtg gtcctgggtc
      601 ccagagggaa aagtcattca ttcctggaga agcggcgtat acctgggcta gccaggtatg
      661 ctgtgacagc tgagggaggc ctcttcccaa taaacttcag tccttctttt tttctggca
//
LOCUS       NM_001437150            1127 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 5, mRNA.
ACCESSION   NM_001437150
VERSION     NM_001437150.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1636669.1,
                                           SRR22582419.609025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000008.1  20594935-20595296
            363-439             JAXUCZ010000008.1  20627474-20627550
            440-1127            JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..1127
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..362
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    341..343
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="upstream in-frame stop codon"
     exon            363..439
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            440..1127
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             521..700
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424079.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    521..685
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    521..685
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 ggcctcgggg gccgagcggg aagtgcggcg tgggcggctg aggccccgtg cgggaaggcg
       61 gccccgcggg gacacgcggg aacacgcgcg gtccgcagag gggcgcgcgt ttgcaggtgg
      121 aggcgggtgg ccgaggaacc cagcggggcg gcggggagcg gctggcctct tccctgctgc
      181 ggcccagggg gccggcggag agtggtggtg gtggccctcg tggcattcgg ggtccccgtg
      241 gggaaggagc tgagcgtggt ttcctgcgtc gcgggctcca ggaccgcccc tcccagtgcc
      301 tcattcacct cacactgcgg tgcgtttgtc ctggggaagt tgagcgggcc gtggagtgga
      361 cggaagaact caggtcaccc tgactggaaa tcagttgacc cacgtcagtg aagcagtggt
      421 tcctgaattt gaagaaaaga ggtggtctgc ccggacagag gagtgtggcc ctttcttcaa
      481 gccctctctg cacatctctt cccagcatcc tctaaccaag atgcgtcagc tcaaagggaa
      541 gccaaagaaa gagacctcca aggacaagaa ggagcggaag caggccatgc aggaggcccg
      601 gcagcagatc accactgtgg tgctgcctac cttggctgtg gtggtgctcc tcattgtagt
      661 gtttgtgtac gtggccacgc gccccatcgt caccgagtga gcaccgccat cctggctttc
      721 ctctgcagac atgtctgcaa tgccgagctc tgggcaggag tgccctgtct cctctgatct
      781 ttgacttgat caatatttct ctacttttgg gggggaaggg aaagggaaca tttatcagtg
      841 aatgtgccat ttacccgatg gtccacttca tgtgcctttc agacttcaaa gcagtgcgtg
      901 tgtgcgtgtg cgtgtgcgtg tgtgcgtgcg tgtctcccct tttctcctga aatcgacgca
      961 cagctgcacc tggggagagg aggcctctcc gggtgacact gtgcttcctg gctccgttca
     1021 cagctttcta aggggacagc ctttcttctc tgtacttgat gggatgtgaa atacgctgac
     1081 tcaaagtgaa atatttattt ttgaataaag gagataatag tcttaaa
//
LOCUS       NM_001437112            6977 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus AT hook, DNA binding motif, containing 1 (Ahdc1),
            transcript variant 3, mRNA.
ACCESSION   NM_001437112 XM_008764151
VERSION     NM_001437112.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6977)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_008764151.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.23034.1,
                                           SRR21887622.460945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  150512215-150512249
            36-167              JAXUCZ010000005.1  150512501-150512632
            168-262             JAXUCZ010000005.1  150512867-150512961
            263-444             JAXUCZ010000005.1  150555407-150555588
            445-661             JAXUCZ010000005.1  150561731-150561947
            662-699             JAXUCZ010000005.1  150562081-150562118
            700-5595            JAXUCZ010000005.1  150562477-150567372
            5596-6977           JAXUCZ010000005.1  150577423-150578804
FEATURES             Location/Qualifiers
     source          1..6977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6977
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="AT hook, DNA binding motif, containing 1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
     exon            1..35
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            36..167
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            168..262
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            263..444
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            445..661
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    609..611
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="upstream in-frame stop codon"
     exon            662..699
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            700..5595
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..5552
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="A.T hook DNA-binding motif-containing protein 1;
                     AT-hook DNA-binding motif-containing protein 1"
                     /codon_start=1
                     /product="transcription factor Gibbin"
                     /protein_id="NP_001424041.1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
                     /translation="MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPP
                     ASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPTPAP
                     DNNSLRHWDNGRVNLHPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPG
                     DLQYSFFSSPSLANSIRSPEERATPHAKPERPNHPLYEPEPEPRDSPQPGQGHGPGAT
                     ATATGLPPEPEPDGPDYPELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLD
                     PQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALD
                     PLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKIL
                     CRRRKAGRGRKVDSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPPALSGPVPELEPE
                     SSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLR
                     VSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAE
                     AAAVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQC
                     AGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKA
                     ARCSFSDFFEGIGKKKKVVAVAATGVVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRS
                     RKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFA
                     STGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASR
                     PESRKASGNYAGPPSSALPAQRGLATFPSRGAKGSPVAVGNSGAGTDPSFQPVLPSRQ
                     TFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAG
                     QSVFAPAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKA
                     SFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASAASSSSSSFQPSP
                     ENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHVSEPNVILDISNYTPQKVK
                     QQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASS
                     APGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQP
                     RGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQ
                     SRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPDLDSKHFPPLAHPP
                     TVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCR
                     DLPLGQPHYESPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHL
                     ASPPATPKADKEPLEMTRPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTA
                     YRYPGFMPQTHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL"
     misc_feature    <2541..2687
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <2541..2687
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <3339..3914
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3339..3914
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            5596..6977
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcagcg gcggcggcgg cggagacgga gagagctcgg agagcagaga aaggcagaga
       61 gagcgagaaa tagagacagg cagacaaaca gacagacaga cagagcggga gggagaaggg
      121 cggcggagga ggagcaggag gactacgcgg ggcgccttcc ctcccagccg ggcgcccgtg
      181 ttgctgtcgc cggcggaaga tagacgcccc ccgaaacccc tcgcttggct cggacccacg
      241 gagccggcag cccagcactc cgatgggagc ttgtctgatt gtctactcat cggcctggac
      301 cccagagcca acccagctga gtgagtgcag agggtcccag gtgaggggca ctgctcaggc
      361 ctgggcagcg actgccctgg agaagctgat ggtggtggag acagaccgtt cctgctgagt
      421 tgggcctcta cagtccctgc tcaggatcgg tatgaagaat caaatgaagc aatgcctgga
      481 cagcttccag cccagtgcct ggcgtgcagt aggtgctcac taaacctgag ctacggtggt
      541 cctttccagg cgctgtccac accccaaggc ctgggctcag gccgaagttg ctccacaata
      601 ccctcagctg acagccagcg actggcagag tccccaagca cgggggccct ctgtttacca
      661 gagatatcca gtgtgacagc ccaggcggca gagccgaggg ttctggtccc ggcctctctc
      721 accctcatgt cagccccggc cccgcccggc ggcccgagga ggacaaggtc aggatgcgtg
      781 tgaagcccca gggcctggtt gtgacttcca gtgccgtgtg cagctctcct gactacctcc
      841 gagagcccaa gtactacccc ggcggccccc caaccccccg gcccttgctt cccacccgcc
      901 cccctgccag cccacctgac aaggcctttt ccacccatac cttctccgag aacccacgcc
      961 cacccccacg tcgggacccc agctcccggc gtccaccagt ccttgccaag ggagacgacc
     1021 tgctaccccc tcgggcagcc cggcctgtct cccaggccca ctgtcccaca ccggccccag
     1081 acaacaactc cctccgtcac tgggacaacg ggcgtgtgaa cctgcatccg gtggtgcagc
     1141 tgattgacat catgaaggac ctgacacggc tgtcccagga cctgcagcac agtggtgtgc
     1201 atctagactg cggcgggctg cgactgagcc gcccacccgc tccaccgccc ggcgacctgc
     1261 agtacagctt cttctcttca cccagcctgg ccaatagcat ccgcagccct gaggagcgtg
     1321 cgacccctca cgccaagcca gagcggccca accaccccct ctatgaacct gagcccgagc
     1381 ccagggatag tccccagcct ggccaaggcc atggtcctgg agccacagcc acggccactg
     1441 gtctgccccc agagcctgag ccagatgggc ctgactaccc tgagctggca gacgctgaca
     1501 tcctcagtga acttgcctcc cttacttgcc ctgaggccca gctcctggag gctcaagccc
     1561 ttgagcctcc ttcaccacag cctgagccgc agctcctgga cccccagccc cgcttcctag
     1621 acccacaagc actagagcct ctaggagaag gtttggaact accacccctg cagcctcttg
     1681 cggatcctct gggactgccg agcttgactc tgcaggccct agacacccta cctgactcct
     1741 tggaatccca gctccttgac cctcaggccc tcgaccccct gcccaagttg ttggatgtcc
     1801 ctggtcgacg tctagagccc cagcaatcct tgggacactg ccaactggct gagcccttac
     1861 gcctggactt gtgctcacct catggtcccc ctgggcctga gggccacccc aagtacgcct
     1921 tgaggcgcac tgataggcca aagatcctgt gtcgcaggcg gaaagctgga aggggacgga
     1981 aggtggattc aggacctgaa ggtcgtctgc tgcctcttcc catgcctaca gggctggcag
     2041 ctgccctggc tgaaccccca ccgctgcccc caccaccacc acctcctgct ctgtcaggcc
     2101 cagttcctga actggagcca gagtcctctc aaactccaat ggtccccacc cgcaaaggca
     2161 agtgcagggg agtgcggcgg atggtggtga agatggcaaa gatccctgtg tcactagggc
     2221 ggaggaacaa gaccacgtac aaagtttcat ccttgagcag cagtctgagt gtggagggca
     2281 aggagctggg cctgagggtg tcgtcggagc ccaccccatt gctgaagatg aaaaacaatg
     2341 gccggaatgt ggtggtggtc ttcccgccag gtgagatgcc tattattctc aagcgaaagc
     2401 gtggccgccc tcctaagaac ctgctgctgg gtcctggcaa acccaaagag ccaacagtgg
     2461 tagctgccga ggctgccgct gtgacagcgg ccaccatggc catgccggag gtgaagaaac
     2521 ggcggcggag gaaacaaaag ctggcatccc cgcagccgtc ctacgcagca gacgccaatg
     2581 acagtaaggc tgagtattcc gatgtccttg ccaagctggc ctttttgaac cgccagagcc
     2641 agtgtgctgg gagatgctcg ccaccccgat gctggacacc cagtgagcct gagtcagtgc
     2701 accaagcccc ggacactcag agcatctctc aattcctgca ccgggtgcag ggcttccgga
     2761 ggcgtggagg caagacagga ggctttggag gtaggggcgg aggccatgca gccaaggcag
     2821 cccgctgttc ctttagtgac ttttttgagg gcattggcaa gaaaaagaag gtggtagcag
     2881 tggcagctac tggggttgtg ggtcctggtc tcactgagct ggggcatcca cgcaaaaggg
     2941 gccgaggcga ggtagatgct gtaactggga aacccaagcg caagaggcgg tcccggaaga
     3001 atgggactct gttcccagag caggtgccca gtggcccagg ctttggggag gccggtgctg
     3061 agtgggctgg ggacaagggt ggtggctggg cccctcacca tgggcaccca ggagggcaag
     3121 ctggccgaaa ctgtggtttc caggggacgg aggccagggc ttttgcctcc actgggctgg
     3181 agagtggggc ttcaggccgt ggcagctact atgctggtgc accctcaggc cagacggagc
     3241 tcagccagga acgccaaaac ctcttcactg gctattttcg gtccctgctt gattcagatg
     3301 actcctctga cctcttggac tttgccctat cggcctctcg cccagagtcc cggaaggcat
     3361 cgggcaacta tgcagggcct ccctccagtg cgctgcctgc tcagcggggg cttgccacct
     3421 tcccaagccg gggagccaag ggtagcccag tggcagtggg caacagtgga gctgggacag
     3481 acccctcctt ccagcctgtc ctgccttccc gtcagacctt tccaccaggc cgggcaacaa
     3541 gctatgggat aaccccagcc acttcagact gccgagcagc tgagaccttc ccaaagctgg
     3601 ctccccctcc ttcagctgtg gcccgctcgc ctacaaccca ccctcctgcc aacacctacc
     3661 cacctcagta tggtggctat ggggcaggac aaagtgtgtt tgccccagca aagccctttt
     3721 caggccagga ctgtgctaat agtaaggact gcagctttgc ctatggcagc ggcaatagcc
     3781 ttcctgcctc acccagcagc gcccacagtg ctggctatgc cccgccgcct actgggggtc
     3841 cctgtctacc gcccagcaag gcctccttct tcaacagctc tgaggggggc cccttctctg
     3901 ggtcagctcc cacacccttg cgctgtgaca gtcgagccag tactgtctca cccggtggct
     3961 acatggtacc caagggcacc acagcttctg ctgcctctgc ggcctcctcc tcttcctctt
     4021 cctttcagcc ctcacctgag aactgtcggc agtttgtggg ggcttctcag tggcctttcc
     4081 ggcaggggta tggaggcctg gactgggcct cggaggcctt tagtcagctc tacaatccca
     4141 actttgactg ccacgtcagt gaacccaatg tgatcttgga catctcgaac tacacgccac
     4201 agaaggtgaa gcagcagact gctgtgtccg agaccttctc cgagtcatcc tctgacagca
     4261 cccagttcaa tcagccagtt ggtggtggtt ttaggcgtgc caacagtgag gcctcaagca
     4321 gtgagggcca gtcaagcctg tccagcctgg agaagctcat gatggactgg aatgaagcat
     4381 catctgctcc cggctacaac tggaaccaga gcgtcctctt tcagagtagc tcaaagcctg
     4441 gccgtggccg gcggaagaag gtggacctgt ttgaggcctc acatttgggc ttttcaacat
     4501 ccacctcagc cactgcctct gggtatccgt ccaaacggag caccggaccc cggcagcctc
     4561 ggggtggccg gggtagtggg gcctgctcag ccaagaagga gagaggtggt acagcggcca
     4621 aagccaagtt catccccaag ccacaaccag tgaatccact gttccaggac agcccagacc
     4681 ttggcctgga ctactatagt ggggacagca gcatgtcacc actgccctcc cagtcgagag
     4741 cctttggtgt gggagaacga gatccctgtg acttcatggg accttactcc atgaatccat
     4801 ccacaccttc tgatggcact tttggccaag gcttccactg tgactctccc agcctgggtg
     4861 ctcctgacct tgacagcaag catttcccac cactggccca cccacccaca gtgtttgatg
     4921 ctggcctgca gaaggcctac tcacccacct gttcaccgac actaggcttc aaggaagagt
     4981 tgcggccacc accttcaaag ctgactgcct gtgagcccct caagcatggt cttcaggggg
     5041 ctagcctgag tcatgcagcc caggcccacc tgagctgccg ggacctaccg ctaggccagc
     5101 ctcactatga gtcccctagt tgcaagggta cagcctattg gtacccacca ggttcagctg
     5161 cccgcagccc accttatgaa ggcaaggtgg gttcagggct gctggctgac ttcctgggca
     5221 ggacggaggc tgtctgcctc agtgcccctc acctggctag cccaccagcc acgcccaagg
     5281 ccgacaagga gccattggag atgacccggc ccccaggtcc accccgtggc cctgctgcag
     5341 ccactgctgg ctatggctgc ccactcctta gtgacttaac tctgtcccct gtgccgaggg
     5401 actcgctgct gcccctgcag gacactgcct acaggtatcc aggctttatg ccgcagacac
     5461 accctggcct gggtgggggt cctaagagtg gcttcctggg gcccatggcg gaacctcacc
     5521 ctgaggacac atttaccgtc acctccctgt agtaccaact gaagtgccga ctggaccacg
     5581 aggttttgtt cctggctttc agaagaccaa tgccaagacc cctcccagcg tccacagcat
     5641 cctctggcag gagcgcctgc ccctctgcct cccacctgcc ccttgcaccc cttgcagccc
     5701 catatcccac ccatgacccc tccttgccca tctcctccac gcagaagccg aaggtgagcc
     5761 ctttctgcac aaaaccagca attgtaaata ctttttaaaa tgtacaaaac ttaaaaacaa
     5821 aacacagttt tagaaaaaga caaaaaaaaa aaagagagag agagcgagag cgagagagag
     5881 agcgtgtgca agaggttgtg agtggggctt cgaggtgtcc agagcccctg caagtgtgca
     5941 ctgagaaatt tatctacagg tcgtttgaca aaaatgaaca atatcctatt tattgtatat
     6001 actgttttat tataaattgt ggattgtata ttgcattctg taaacctgct gtggtcccgt
     6061 ggtgtgcaaa ttcgcatggt ggggggggag ggagaacctc ttttgggggc tttttttttt
     6121 tttttctttt tttttttttt cctttttcac tcttgggttt tctcttctgt tgctgttgtt
     6181 gttttttgtt ggcaggacac acccaaagat ccaagtttgt attaaaaaga aatgaagaaa
     6241 agcaaaaaaa aaaaaaaaaa aaaaaaaaaa ccaacttgtg tctgtaaaac agggtacatg
     6301 agggtgggtg ggactgtact ggtgatgtca gcctctggtc cttctgggag ttgaagtacc
     6361 tcaggatgtt cctggtttcc ctacctctga gtcctctcat ctgcctagtg tctcggtgtc
     6421 atctccgtcc cccaccagac tccgagtgtt ttgcccacat gtatgtttgt gcacagcatg
     6481 tgtgagttgg tgcccttgaa ggtcagaaaa gggcatggaa tccccgttac agacagctat
     6541 aagctgtcat tccgatgctg ggactcaaat ccatgtccta tgcaagaaca gtgagtgttc
     6601 tcaacatcag aaacattgcg ttgactcgtc cccgctcctg tcctacatcc cgtggctccc
     6661 acagatgctt tcttttgcct gaagagtccc atggtaagtt tggtcaccat cttcttcctc
     6721 tcgatgccct cagtccacct caggtcccag agcaccaccc cgacgtctgt ttgtcctgtc
     6781 tccctgacca ttaaggctcc agacttctat catggtccta agaggccgat cttcatttta
     6841 ctgaggcaga gtgtctctgt gtggccccag ctatcctaga acttgtatgt agtatgtaaa
     6901 ccaggctgac cagactcaga cctgcctgcc tcatcttccg agaactggga ttacacatgt
     6961 gccactgcac ccagcaa
//
LOCUS       NM_001437156            3921 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 2, mRNA.
ACCESSION   NM_001437156 XM_063288077
VERSION     NM_001437156.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3921)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3921)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3921)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3921)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3921)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3921)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3921)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3921)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3921)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3921)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_063288077.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29950.1,
                                           SRR26643299.25298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1901           JAXUCZ010000005.1  158589800-158590006
            1902-1991           JAXUCZ010000005.1  158590386-158590475
            1992-2151           JAXUCZ010000005.1  158590555-158590714
            2152-2272           JAXUCZ010000005.1  158590833-158590953
            2273-2397           JAXUCZ010000005.1  158591073-158591197
            2398-2558           JAXUCZ010000005.1  158591857-158592017
            2559-2675           JAXUCZ010000005.1  158592132-158592248
            2676-2743           JAXUCZ010000005.1  158592343-158592410
            2744-2896           JAXUCZ010000005.1  158592944-158593096
            2897-2993           JAXUCZ010000005.1  158593200-158593296
            2994-3217           JAXUCZ010000005.1  158593909-158594132
            3218-3369           JAXUCZ010000005.1  158594217-158594368
            3370-3539           JAXUCZ010000005.1  158594521-158594690
            3540-3921           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3921
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3677
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 2"
                     /protein_id="NP_001424085.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKATVFARMAPEQKTQLVCELQ
                     RLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRC
                     SLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGP
                     ALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDN
                     LPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGLILVP
                     GLLQGPLGLRNIADSSFKLLLLGLVAFNFVGAFMLESVLDQCLPACLQWLRPKRASKK
                     QFKQLQRELAERPWPTLPVGSVR"
     misc_feature    282..3503
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3503
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1901
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2397
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2558
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2675
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2743
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2896
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2993
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3217
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3369
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3539
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3921
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caagacaggc accctcacgg aggacggatt ggacataatg ggggtggtgc
     1741 ccctaaaggg gcagatgttg ctgccactgg tcccagagcc ctgccacctg cccccagggc
     1801 ccctcctccg agcactggtc acctgtcatg ccctcagcca gctacatgat accttggtgg
     1861 gcgaccccat ggatctcaag atggtggagt ctacaggctg ggtcttagag gagggttcgg
     1921 ctgcaggctc agcacctgag acccaggtct tggtggtaat gcgaccccca cccagggggc
     1981 ctcagcaaca ggaagagtca ccagagccag tcagtgtcct ccgccgcttc cccttctcct
     2041 ctgccctgca gcggatggac gtggtggtga catggccagg ggccacccag cctgaggcct
     2101 acgtcaaagg ttccccagag cttgtggcca gcctctgcag ccccgagaca gtgcccagag
     2161 actttcctca ggtactgcag agctacacag ctgctggcta ccgagttgtg gccctggctg
     2221 gcaagccact gcccactgcg cccagccttg aggccgctca gcagctgaca agggacactg
     2281 tggagcagga gctgagcctc ctggggctgc tggtcatgcg gaacctgctg aagccacaga
     2341 cgaccccagt tatacagacc ctgaggaaga cgggcatccg tactgttatg gtgacagggg
     2401 acaacctgca gacagcagtc acggtggcca aagcgtgtgg catggtgggc acccaggagc
     2461 acctggctat catccatgcc acccaccctg agcagggcca gcctgctgcc cttgagttcc
     2521 tgccaactga gccctctgcg gccatgaatg gggcaaagga tcctgtgcag gccacggact
     2581 accccgtgga gccggagtcc cagtcccgtc acctggccct cagtgggtcc acgtttgctg
     2641 tccttcagaa gcacttcccc aagctgctgc ccaaggccac cgtctttgcc cgcatggccc
     2701 cggagcagaa gacacagcta gtgtgtgaac ttcagagact tcagtactgc gtgggcatgt
     2761 gcggggatgg agccaatgac tgtggggccc tgaaggcggc tgacgtgggc atctcactgt
     2821 cccaggcaga ggcctcagtg gtctctccgt tcacctccag catggccagt attgaatgtg
     2881 tgcccactgt catcagggaa ggccgctgct ctctggacac ttcattcagc gtcttcaagt
     2941 atatggccct atacagcctg acccagttca tctctgtcct cattctctac acaatcaaca
     3001 ccaacctggg agacctacag ttcttggcca tcgacctgtt catcaccacc acggttgccg
     3061 tgctcatgag ccgcaccggc cctgcactga ccttggtgcg agcacggcca ccaggggcgc
     3121 tgctgagcgt gcctgtactt ggcagtttgc tgctgcaggt ggccttggtg gccggcatcc
     3181 agcttggggg ctactttttg gtcatagctc agccctggtt tgtgcctctg aacagaactg
     3241 tacccgcacc tgacaacctg cccaactacg agaacacagt gatcttctct ctgtctggct
     3301 tccagtacct catcctggcc gcagcggtgt ctaagggggc acccttccgc cagccgctct
     3361 acaccaacgt gcccttcctg gtggccctgg cgctcttggg ctctgtcctg gtgggcctca
     3421 tcctggtccc cggcctcctg caggggccac taggactgag gaacattgcg gacagctctt
     3481 tcaagttgct gctgctgggt ctggtcgcct tcaactttgt gggcgccttc atgctggaga
     3541 gcgtgctgga ccagtgtctc ccagcctgcc tgcagtggct gcggcctaaa cgggcctcca
     3601 agaagcaatt caagcagcta caacgggagc ttgctgaacg tccatggccc actctgcccg
     3661 ttggctccgt gaggtagtgc aggccttgga gggcatgctg gacactggat ctccctgccc
     3721 ctgagccatg accggaactc tccctagaga cagtaccagt cacctcccac agccctgagg
     3781 ttggctgtca cactcctggg gacacactcg cctggggagg cgttgattgt tgcctcactg
     3841 tgtagagaca gcagctacca actccatccg gagcagctgt catggagcaa ataaagtgcc
     3901 ggctttcctg tcttggcagc a
//
LOCUS       NM_001437159            3847 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 6, mRNA.
ACCESSION   NM_001437159 XM_063288078
VERSION     NM_001437159.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3847)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3847)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3847)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3847)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3847)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3847)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3847)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3847)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3847)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3847)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_063288078.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.21176.1,
                                           SRR26643298.29954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1901           JAXUCZ010000005.1  158589800-158590006
            1902-1991           JAXUCZ010000005.1  158590386-158590475
            1992-2151           JAXUCZ010000005.1  158590555-158590714
            2152-2272           JAXUCZ010000005.1  158590833-158590953
            2273-2397           JAXUCZ010000005.1  158591073-158591197
            2398-2558           JAXUCZ010000005.1  158591857-158592017
            2559-2675           JAXUCZ010000005.1  158592132-158592248
            2676-2743           JAXUCZ010000005.1  158592343-158592410
            2744-2896           JAXUCZ010000005.1  158592944-158593096
            2897-2993           JAXUCZ010000005.1  158593200-158593296
            2994-3217           JAXUCZ010000005.1  158593909-158594132
            3218-3369           JAXUCZ010000005.1  158594217-158594368
            3370-3465           JAXUCZ010000005.1  158594595-158594690
            3466-3847           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3847
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3515
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 6 is encoded by transcript variant 6;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 6"
                     /protein_id="NP_001424088.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKATVFARMAPEQKTQLVCELQ
                     RLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRC
                     SLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGP
                     ALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDN
                     LPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGATRTEEHCGQLFQVAAAGSG
                     RLQLCGRLHAGERAGPVSPSLPAVAAA"
     misc_feature    282..3368
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3368
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1901
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2397
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2558
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2675
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2743
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2896
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2993
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3217
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3369
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3465
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3847
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caagacaggc accctcacgg aggacggatt ggacataatg ggggtggtgc
     1741 ccctaaaggg gcagatgttg ctgccactgg tcccagagcc ctgccacctg cccccagggc
     1801 ccctcctccg agcactggtc acctgtcatg ccctcagcca gctacatgat accttggtgg
     1861 gcgaccccat ggatctcaag atggtggagt ctacaggctg ggtcttagag gagggttcgg
     1921 ctgcaggctc agcacctgag acccaggtct tggtggtaat gcgaccccca cccagggggc
     1981 ctcagcaaca ggaagagtca ccagagccag tcagtgtcct ccgccgcttc cccttctcct
     2041 ctgccctgca gcggatggac gtggtggtga catggccagg ggccacccag cctgaggcct
     2101 acgtcaaagg ttccccagag cttgtggcca gcctctgcag ccccgagaca gtgcccagag
     2161 actttcctca ggtactgcag agctacacag ctgctggcta ccgagttgtg gccctggctg
     2221 gcaagccact gcccactgcg cccagccttg aggccgctca gcagctgaca agggacactg
     2281 tggagcagga gctgagcctc ctggggctgc tggtcatgcg gaacctgctg aagccacaga
     2341 cgaccccagt tatacagacc ctgaggaaga cgggcatccg tactgttatg gtgacagggg
     2401 acaacctgca gacagcagtc acggtggcca aagcgtgtgg catggtgggc acccaggagc
     2461 acctggctat catccatgcc acccaccctg agcagggcca gcctgctgcc cttgagttcc
     2521 tgccaactga gccctctgcg gccatgaatg gggcaaagga tcctgtgcag gccacggact
     2581 accccgtgga gccggagtcc cagtcccgtc acctggccct cagtgggtcc acgtttgctg
     2641 tccttcagaa gcacttcccc aagctgctgc ccaaggccac cgtctttgcc cgcatggccc
     2701 cggagcagaa gacacagcta gtgtgtgaac ttcagagact tcagtactgc gtgggcatgt
     2761 gcggggatgg agccaatgac tgtggggccc tgaaggcggc tgacgtgggc atctcactgt
     2821 cccaggcaga ggcctcagtg gtctctccgt tcacctccag catggccagt attgaatgtg
     2881 tgcccactgt catcagggaa ggccgctgct ctctggacac ttcattcagc gtcttcaagt
     2941 atatggccct atacagcctg acccagttca tctctgtcct cattctctac acaatcaaca
     3001 ccaacctggg agacctacag ttcttggcca tcgacctgtt catcaccacc acggttgccg
     3061 tgctcatgag ccgcaccggc cctgcactga ccttggtgcg agcacggcca ccaggggcgc
     3121 tgctgagcgt gcctgtactt ggcagtttgc tgctgcaggt ggccttggtg gccggcatcc
     3181 agcttggggg ctactttttg gtcatagctc agccctggtt tgtgcctctg aacagaactg
     3241 tacccgcacc tgacaacctg cccaactacg agaacacagt gatcttctct ctgtctggct
     3301 tccagtacct catcctggcc gcagcggtgt ctaagggggc acccttccgc cagccgctct
     3361 acaccaacgg ggccactagg actgaggaac attgcggaca gctctttcaa gttgctgctg
     3421 ctgggtctgg tcgccttcaa ctttgtgggc gccttcatgc tggagagcgt gctggaccag
     3481 tgtctcccag cctgcctgca gtggctgcgg cctaaacggg cctccaagaa gcaattcaag
     3541 cagctacaac gggagcttgc tgaacgtcca tggcccactc tgcccgttgg ctccgtgagg
     3601 tagtgcaggc cttggagggc atgctggaca ctggatctcc ctgcccctga gccatgaccg
     3661 gaactctccc tagagacagt accagtcacc tcccacagcc ctgaggttgg ctgtcacact
     3721 cctggggaca cactcgcctg gggaggcgtt gattgttgcc tcactgtgta gagacagcag
     3781 ctaccaactc catccggagc agctgtcatg gagcaaataa agtgccggct ttcctgtctt
     3841 ggcagca
//
LOCUS       NM_145674               3388 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus glycoprotein alpha-galactosyltransferase 1
            (Ggta1), transcript variant 1, mRNA.
ACCESSION   NM_145674
VERSION     NM_145674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3388)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   2  (bases 1 to 3388)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 27, 2025 this sequence version replaced NM_145674.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222249.1, SRR26643297.11073.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000003.1  39206544-39206720   c
            178-293             JAXUCZ010000003.1  39167649-39167764   c
            294-470             JAXUCZ010000003.1  39152627-39152803   c
            471-559             JAXUCZ010000003.1  39151586-39151674   c
            560-661             JAXUCZ010000003.1  39144883-39144984   c
            662-799             JAXUCZ010000003.1  39137701-39137838   c
            800-3388            JAXUCZ010000003.1  39130466-39133054   c
FEATURES             Location/Qualifiers
     source          1..3388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3388
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="glycoprotein alpha-galactosyltransferase 1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     exon            1..177
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            178..293
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    207..209
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="upstream in-frame stop codon"
     exon            294..470
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1493
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /EC_number="2.4.1.87"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycoprotein galactosyltransferase alpha 1, 3;
                     N-acetyllactosaminide alpha-1,3-galactosyltransferase;
                     glycoprotein, alpha-galactosyltransferase 1,3;
                     UDP-galactose:beta-D-galactosyl-1,
                     4-N-acetyl-D-glucosaminide
                     alpha-1,3-galactosyltransferase"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     alpha-1,3-galactosyltransferase isoform 1"
                     /protein_id="NP_663707.1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
                     /translation="MVTMPQDLHVKVSMSRSKSETSLLSSRSGSQEKIMNVKGKIILS
                     VLMVSTVLVVFWEYVNRTHSYQEEDIERAREKGRNGDSIVEPQLWDWFNPKNRPEVLT
                     VTPWKAPIVWEGTYDTALLEKYYARQKITVGLTVFAVGKYIEHYLEDFLESANKYFMV
                     GHRVIFYVMMDDTSRMPAVHLSPLHSLQVFEIRSEKRWQDISMMRMKTIGEHILDHIQ
                     HEVDFLFCMDVDQVFQDNFGVETLGQLVAQLQAWWYKASPDEFTYERRELSAAYIPFG
                     EGDFYYHAAVFGGTPVHILNLTRECFKGILQDKKHDIEAQWHDESHLNKYFLFNKPTK
                     ILSPEYCWDYHIGLPSDIKNVKIAWQTKEYNLVRSNV"
     misc_feature    498..551
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3L7M0.2);
                     transmembrane region"
     misc_feature    633..1484
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    633..1484
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    order(786..794,801..803,978..980,990..992,1059..1067,
                     1461..1463,1467..1469,1479..1481)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(786..794,801..803,978..980,990..992,1059..1067,
                     1461..1463,1467..1469,1479..1481)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(786..794,801..803,1059..1067,1125..1136,1161..1163,
                     1218..1220,1326..1328,1335..1337)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     misc_feature    order(786..794,801..803,1059..1067,1125..1136,1161..1163,
                     1218..1220,1326..1328,1335..1337)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     misc_feature    1263..1265
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3L7M0.2); glycosylation site"
     exon            471..559
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            560..661
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            662..799
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            800..3388
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagatc tgactgcctc tttcatttgc ctggaggtag ctaggtgtgt ctcaggaggc
       61 tggagattct gggtggagcc ctagtcttgc cttttcttag ccgagcgaca ccttcccttg
      121 tagactcttg gaatgagaaa taccgattct gctgaagacc tcactctcag gatctgggag
      181 ttggagccct gtaccttcct ttcctctgag ccctgtctcc ttcggcaggc gggagctcca
      241 tagaactcgg ttgctctgct gtttgctttg gagaggacac agcggacaat gaggttgact
      301 atgaactcaa gagatatact taccccagtc tcctggaatt aaaggcctgt accgccttgc
      361 ctggacctaa gattatcatg gttactatgc ctcaagatct ccacgtcaag gtctccatgt
      421 caagatccaa gtcagaaaca agtcttctat cctcaagatc tggatcacag gagaaaataa
      481 tgaatgtcaa ggggaaaata atcctgtcgg tgctgatggt ctcaaccgtg cttgtcgtgt
      541 tttgggaata tgtcaacagg acccacagtt atcaagaaga ggacatagag agagcgagag
      601 aaaaggggag aaatggagac agcattgtag agcctcagct ctgggactgg ttcaatccaa
      661 agaaccgccc ggaggttttg acggtgaccc cgtggaaggc gccgattgtg tgggaaggca
      721 cttacgacac agctctgttg gaaaagtact atgccagaca gaaaatcact gtggggttga
      781 cagtttttgc tgtgggaaag tacattgagc attacttaga agactttctg gagtctgcta
      841 acaagtactt catggtcggc caccgggtca tattttacgt catgatggac gacacctcca
      901 gaatgccggc cgtccatctg agtcctctgc attccttgca agtgttcgag atcaggtctg
      961 agaagagatg gcaggatata agcatgatgc ggatgaaaac catcggggag cacatcctgg
     1021 accacatcca gcacgaggtt gacttcctct tctgcatgga cgtggaccaa gtctttcaag
     1081 acaactttgg tgtggagacc ctgggccagt tggtagctca gctccaggcc tggtggtaca
     1141 aggccagccc tgacgagttt acctatgaga ggcgggaact ctcggcagcc tacattccat
     1201 tcggagaggg ggatttttac taccacgcgg ccgtttttgg aggaacgccc gttcacattc
     1261 tgaacctcac cagggagtgc tttaagggga tcctccagga caagaaacat gacatagaag
     1321 cccagtggca tgacgagagc cacctcaaca aatacttcct tttcaacaaa cccactaaaa
     1381 tcctatcccc ggagtattgc tgggactatc atataggcct gccctcagat attaaaaatg
     1441 tcaagatagc ttggcagaca aaagagtata atttggtgag aagcaatgtc tgacttcaaa
     1501 cgtgatggaa acctgacacc attattctgg tgaatccctc taaaaagcag taacacttga
     1561 tttcaacttt aaaaaaaagt ccccaaatca aaacccacca ccatggcata cacgtatgaa
     1621 ttctccttat aaccttgagc cttgtaatat gtgagagggt ctatggtaag taatcaggta
     1681 taaattctca gtgattcctt atatattccg ggttttgggg gtcatactaa ctaaataagc
     1741 aggaatggaa attaatttgc attaggtaaa gaagacacaa gaacattctg tccagtgtgt
     1801 cagataactc actataggcc agggtgttga gagaagcatt tggcagcagg atgggttggg
     1861 tcagagctag ggggctccgt ccccttggtt tcattgtctt cctcctcttg gagattctaa
     1921 agaaacacag agaggttttg caaccagagg acttcaggaa ggataccaat gagatcgtca
     1981 aagtctttaa atctgactct ggcttccagg agctgctggc agtccaggcc ctgtggtgca
     2041 taatgaaggc agagagtgcc actaggtatc ttggtggcac atgttcagag tcccaggaac
     2101 tatgggggtg acaactatgc tctggtggag ggacataggg tatggtgttg gtgtagttac
     2161 aaacacaggc aggtttctca acaacgacca acagcaggga tcgaacagaa agtgcatttt
     2221 gttttaccca aatcctgttc acattgttag ccttgtgtgt ggagtcctgt ggagagggga
     2281 ggagagtacc tcagtggact gaggagaagg acccagtttt tatcagaagg caatctgtca
     2341 tcatctggtc ctaccatctg ctctgaacct cagagttcct cagcccacca tgttctagta
     2401 tggaggactg acacggagcc agtgacggaa gacaaagccc tccgtcacat gacctcatgc
     2461 cttgtctgca ctatgcaagt atgacagcca gacagatgta ccaggcaacg tggttaactg
     2521 acttcatggc gatgggagat gcagtcacca cgaccaagca gctgaaggtt cagttccctt
     2581 ctctgagaga agtgtgagag cctgtctatg agtggttctt aacctgtggg tcgcgacccc
     2641 ttaggtatga atgacccttt tcacaggggt cgcctacgac cattggaaag cacagacatt
     2701 tacattatgg tttgtaacag tagcaaaatt acagttaatg aagtagtaac gaacatgatt
     2761 ctgtggttgg gggtaacccg tatcgtgagg tcacagtatc tgggaagcag agaaccattt
     2821 ctctatatgg gtatttaagc aaataagtcg atctgtattt ctgtgtacac atatatttat
     2881 attttgcttg tcttcccgtc taggtcatca gtttctacct ttaagccatt tatttaaaaa
     2941 gctattgcac tgtcttggtg aacagtgtgt ggggcttcaa taaaaaaggg tcttgtgcgt
     3001 gtctacatgg ttccacctct tacttaaaaa aacaaaaaag tcgcatatcc caaggcaaca
     3061 aaccccacag aattcccgaa ccaatgggcg ttgcaaaagg aagtggagcc tgcacatctg
     3121 ttaagaattc tgcctgtcta tctctcacct tgtgctagat ccagtctaaa gtgggagggt
     3181 ttaatggtcc tgaaccaaag aaataatcgg ttctgaaagt gtaggggaga agacagaagg
     3241 aatttggagc gaattgattt ttctaaataa aaatgcatct acaatttaaa ttcctaatga
     3301 gtaaatttag gattttatta aaggtgatgt ttagacattt ctaaaatata cattctggtt
     3361 tacaatcaaa taaattattt tctcagta
//
LOCUS       NM_001437105            1477 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ADP-ribosyltransferase 3 (Art3), transcript
            variant 3, mRNA.
ACCESSION   NM_001437105 XM_006250728
VERSION     NM_001437105.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Shi,W., Gong,P., Fan,J., Yan,Y.H., Ni,L., Wu,X., Cui,G., Wu,X.,
            Gu,X. and Chen,J.
  TITLE     The expression pattern of ADP-ribosyltransferase 3 in rat traumatic
            brain injury
  JOURNAL   J Mol Histol 43 (1), 37-47 (2012)
   PUBMED   22037978
  REMARK    GeneRIF: ART3 may play important roles in CNS pathophysiology after
            traumatic brain injury (TBI).
REFERENCE   2  (bases 1 to 1477)
  AUTHORS   Wang,B., Golemis,E.A. and Kruh,G.D.
  TITLE     ArgBP2, a multiple Src homology 3 domain-containing,
            Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed
            cells and localized in stress fibers and cardiocyte Z-disks
  JOURNAL   J Biol Chem 272 (28), 17542-17550 (1997)
   PUBMED   9211900
REFERENCE   3  (bases 1 to 1477)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006250728.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.49565.1,
                                           SRR26643288.51094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000014.1  15949505-15949617   c
            114-191             JAXUCZ010000014.1  15948319-15948396   c
            192-900             JAXUCZ010000014.1  15943480-15944188   c
            901-933             JAXUCZ010000014.1  15933334-15933366   c
            934-966             JAXUCZ010000014.1  15931791-15931823   c
            967-999             JAXUCZ010000014.1  15926899-15926931   c
            1000-1053           JAXUCZ010000014.1  15924735-15924788   c
            1054-1086           JAXUCZ010000014.1  15923643-15923675   c
            1087-1477           JAXUCZ010000014.1  15921540-15921930   c
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1477
                     /gene="Art3"
                     /note="ADP-ribosyltransferase 3"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
     exon            1..113
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            114..191
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1217
                     /gene="Art3"
                     /EC_number="2.4.2.31"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; ecto-ADP-ribosyltransferase 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform 2
                     precursor"
                     /protein_id="NP_001424034.1"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
                     /translation="MKMGHFELVTTLLAAMVLMDVFQVQAEVLDMAENVFDDEYLKCN
                     SRMEMKYIPRMHGEELANDELLQSVWDKAGIQWEAQKAQLSLPKNFKDAYGIALTAYV
                     TEAQDQSPFYHTFNRAVKIAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEESYKNV
                     VYSTSPNISFAFGEQNQARLGNFTLAYSAKPQTANEQRLLTIQTCFGVAVGKLLNKES
                     EGIVLIPLSEVFQVSRKGTDDDLILHSINSTCSYYECSFLGGLKAGSCTTNPENPDPG
                     YLNNPGRKSLDSVKMPEIKVLQGEENPLLPDEKPEDRNRGKANVPTPGLVPVPGPKSH
                     PSSSSGHRLLPSDTASTILLIAAAVDFIAL"
     sig_peptide     123..200
                     /gene="Art3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    207..875
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     misc_feature    207..875
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     exon            192..900
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..933
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..966
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            967..999
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1053
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1086
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1477
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctctcact gtcaacaaca tcctgtcctg gagggaagat caccccagct gagagtggga
       61 atcggtttga gtcggggcat catttaaacg tcctgcaaag gcacaaacgc cagaagagaa
      121 aaatgaagat gggacatttt gaattggtca ccacgctgct ggcagccatg gttctaatgg
      181 acgtcttcca ggtgcaggcg gaagtgttag acatggcaga gaatgtgttt gacgacgaat
      241 atttgaagtg caatagcaga atggaaatga agtatatccc tcggatgcac ggtgaggagt
      301 tggcaaatga cgagctcctg cagagtgtgt gggacaaggc agggatccag tgggaggcgc
      361 agaaggctca gctctccctc cctaagaact tcaaggatgc ctatggaata gctctgacag
      421 cttacgtaac cgaggctcag gaccagagtc ccttttacca cacattcaac cgtgctgtga
      481 agatagccgg cctgtcccga agacgctaca tctataactt tccgttcaaa gcgtttcatt
      541 tttacctggt aagagccctg cagctgctga gacgaccttg tgaggagagt tacaaaaacg
      601 tggtgtacag cacgagcccc aacatttcat tcgctttcgg cgagcaaaac caagccaggc
      661 tgggcaactt cacgttggcg tattcagcca aaccccagac agctaacgag caacggctgc
      721 taaccatcca gacctgcttt ggagttgccg tgggaaagct tcttaataaa gaaagtgagg
      781 gaattgttct aatccctctg agtgaggttt ttcaggtgtc aaggaaagga actgacgacg
      841 acctcatcct tcacagcata aacagtacct gcagctacta cgagtgttca ttcctcgggg
      901 gtctaaaagc tggtagttgt accacaaacc cagaaaatcc tgaccctgga tatctcaaca
      961 accctggtag gaaaagcctt gactctgtga aaatgccaga aattaaagtg ctacaaggag
     1021 aggaaaatcc cctcctgcca gatgaaaagc ctgaagacag aaatcgagga aaggccaacg
     1081 ttcctactcc aggtctggtt ccggttccag gtccgaagtc ccatccttcg tcatcctctg
     1141 gccatcggct ccttccgtca gacacagcat ccaccatttt actcatcgct gctgctgtgg
     1201 acttcatcgc tctatagctt ggaacgctac cttattctct atctgaaaga tgctacgggg
     1261 atcccacagg aggtccagag aaaaaaatag ttttcctttg gacagactca ctgtgtaaaa
     1321 gaagaactgt atatttgtgc cttgttctgc aagttaaaaa gctggtccag acagtgtcat
     1381 agaattaact tttcatttct gtattaattt taggactgca aaaatcccaa agctgtatac
     1441 ttagattgga ttcaataaaa agtttaagtt tactaaa
//
LOCUS       NM_001437134            2899 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus P2Y receptor family member 10 (P2ry10),
            transcript variant 1, mRNA.
ACCESSION   NM_001437134
VERSION     NM_001437134.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.65743.1,
                                           SRR26360186.1830181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               JAXUCZ010000021.1  76265469-76265812
            345-2899            JAXUCZ010000021.1  76277303-76279857
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2899
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="P2Y receptor family member 10"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
     exon            1..344
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="upstream in-frame stop codon"
     exon            345..2899
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1380
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="purinergic receptor P2Y, G-protein coupled, 10;
                     purinergic receptor P2Y10"
                     /codon_start=1
                     /product="putative P2Y purinoceptor 10"
                     /protein_id="NP_001424063.1"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
                     /translation="MGSNSTSTVESNCNAINVTFQNSLYATTYIFIFIPGLLANSAAL
                     WVLFRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKY
                     LNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAAVWIIVGTACLPFPIMRS
                     AGLANNTDSCFADLGYKQMDPLVLVTMITIAELAGFVIPVLTIACCTWKTTVSLKHPP
                     IAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKENIITSCPIVKSAMYFH
                     PFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVS"
     misc_feature    460..1308
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    460..1308
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    466..540
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    466..540
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    565..630
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    565..630
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    676..744
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    676..744
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    808..858
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    808..858
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    946..1017
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    946..1017
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    1084..1152
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1084..1152
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1210..1287
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1210..1287
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
ORIGIN      
        1 accccaaaac tactggatat agtaaggaaa acattttggg ttgtggtgga aggaaataag
       61 gtgggaaaca gttaagaggg tgaggacgta tcaagctgtt tgtgcagcac agacgaaata
      121 gagaagaaat cacacttgac taacgtcatg tgctcaaggg acttaccttc gttctgtgca
      181 agtaaggttt ctgtggtgag acattaatgt gctctacttc ctctttcaac actaattttt
      241 ttttcagtta tcagcaggat atgtgcttgc tgcccagact tgtacatttt tactcccatc
      301 tctttgcaaa tatacaggac tccttattcc agctcagcat cagggaacca taattccaca
      361 gtttttcttg atgaacatac tgagatattc aagatgggca gcaatagcac cagcactgtt
      421 gagagtaatt gcaatgccat taatgtgaca tttcagaact ctctgtatgc aaccacctac
      481 attttcatat tcatcccggg tctcctggct aacagtgcag ccctgtgggt tctgtttcgc
      541 ttcatcagca agaagaataa agccatcatt ttcatgatca acctctcagt ggcagacctt
      601 gctcatatcc tgtccttacc tcttcggatt tactattata tcaatcgtca ctggccattc
      661 cagagggccc tttgcctgct gtgcttctat ctgaaatatc tcaacatgta tgccagcatt
      721 tttttcttga cctgcattag ccttcagagg tgcctctttc ttctcaagcc attcagagcc
      781 agaaactgga agcggaggta cgacgtaggc atcagtgctg ctgtctggat cattgtgggg
      841 actgcctgtt tgccatttcc catcatgaga agtgctggct tagctaataa cacagactca
      901 tgctttgctg atcttgggta caaacagatg gatccattgg ttctggtcac catgattaca
      961 attgctgaac ttgctggatt tgtgattcca gtgctcacaa tcgcatgttg tacctggaaa
     1021 acaactgtat ccttgaaaca cccaccgatt gcttttcaag ggattagtga gaggaaaaaa
     1081 gcattgcgga tggttttcat gtgtgctgca gtcttcgtca tctgcttcac tccttatcac
     1141 attaacttca ttttttacac catggtaaag gaaaacatca ttaccagttg tcccattgtg
     1201 aaaagtgcca tgtatttcca tcctttttca ctgtgccttg caagtctctg ttgtcttttg
     1261 gacccgattc tgtattattt catggcttca gagtttcgtg accaactatc tcgccatggg
     1321 agctctgtta ctcgttctcg tctcatgagc agggaaagtg gttcatccat ggttagctaa
     1381 aaccagataa ttcttcagtt aggattctct ttacctaatg ttctgtggcc tcgtccaaag
     1441 gcaggaattg ccaggcaaat tatttcttta actgaacctt ggaaatagaa gaaaaagctt
     1501 tcttgtgtga tagttgtggt ctccacagat gaaggaagca taatgtgaaa aaaatgtggg
     1561 agtaaaaata aaaataagat ccatgtgctt ccaacttaca atttatgaca ttctattagt
     1621 tacaagtctc agatcaagat caagttttta acagatgttt ccatccaaat ataaattgaa
     1681 tgcatgtatt tacatttgtc ttctgtaaat agaatagtac tgagttgcca gatatatatt
     1741 aatctttaca aaaaagtaaa tgtccaccat ggaataattt tatttctgaa tgaataaaag
     1801 atttcaggtc tttctaaaac attaaacagg gacaaagtga cacaaaggtt acaaaaatgt
     1861 gtgaatgaat tttagcactg cattcttgct actgaatgca gcgcatgaaa atgcactcat
     1921 tggatgttta tagatgttta ttattttcta ggttgggagt ttgctatgta tttttacaaa
     1981 gaacatctca tcttactttt tcaatacaag tgacaataaa tgtggaaatt acaaatacaa
     2041 atgaataaat gtaacagccg agaggttaaa caacatgcct caggattaac agttaagtat
     2101 acatggcata tgtttatatt attgcctctg cttatatttt tatattaatt aagtcaatac
     2161 caagtttgag tttaatgctg aagatgcaaa ctgaagataa gcatagtagg tatggataat
     2221 tttaacacaa tgttcttggg ctcatcaata aatccatatg ttgaggatta gcatgatact
     2281 ggttagcgta ttctatgata aatatattgt cctattagtg taatcatctg tatagtcttg
     2341 atgagaagaa acttagtagt tcattatttc aaagtcaatt ttatggctta atataagcca
     2401 tgcaaatctc ataaaataga aagctatgaa actgagccac attttagaaa atgtaggttt
     2461 ccacttaaaa attctccatt aaaaatactt atagtatatg taactaaata aaatctcaag
     2521 ggttttctga tatcagaact cacacaattg cactagaacc agagaaatat tatcacattg
     2581 tgaataaata tgagagaaat atgtgaactt atttttttct taaagttaca gataatattt
     2641 taagtgttca tatagatcat acaaatacaa cagacccctt agcttttcag gttgacaatt
     2701 aactggcatt ttatgtctga aattaacaga gcgtagacat ttggggtgca ggcaagaaaa
     2761 ggaagtggta ggcatgcatt tgtgaagact aaggaagagg aagggaccac aaaaggagga
     2821 attaaaaaga acatttgttg gtttctttga ccatgagata gttctgtaat tataatgtaa
     2881 taaagctttt ttaattgga
//
LOCUS       NM_001437132            3402 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus glycoprotein alpha-galactosyltransferase 1
            (Ggta1), transcript variant 2, mRNA.
ACCESSION   NM_001437132 XM_006234033
VERSION     NM_001437132.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006234033.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166599.1, SRR26643429.11435.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000003.1  39207771-39207961   c
            192-307             JAXUCZ010000003.1  39167649-39167764   c
            308-484             JAXUCZ010000003.1  39152627-39152803   c
            485-573             JAXUCZ010000003.1  39151586-39151674   c
            574-675             JAXUCZ010000003.1  39144883-39144984   c
            676-813             JAXUCZ010000003.1  39137701-39137838   c
            814-3402            JAXUCZ010000003.1  39130466-39133054   c
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3402
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="glycoprotein alpha-galactosyltransferase 1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     exon            1..191
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            192..307
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="upstream in-frame stop codon"
     exon            308..484
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1507
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /EC_number="2.4.1.87"
                     /note="isoform 1 is encoded by transcript variant 2;
                     glycoprotein galactosyltransferase alpha 1, 3;
                     N-acetyllactosaminide alpha-1,3-galactosyltransferase;
                     glycoprotein, alpha-galactosyltransferase 1,3;
                     UDP-galactose:beta-D-galactosyl-1,
                     4-N-acetyl-D-glucosaminide
                     alpha-1,3-galactosyltransferase"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     alpha-1,3-galactosyltransferase isoform 1"
                     /protein_id="NP_001424061.1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
                     /translation="MVTMPQDLHVKVSMSRSKSETSLLSSRSGSQEKIMNVKGKIILS
                     VLMVSTVLVVFWEYVNRTHSYQEEDIERAREKGRNGDSIVEPQLWDWFNPKNRPEVLT
                     VTPWKAPIVWEGTYDTALLEKYYARQKITVGLTVFAVGKYIEHYLEDFLESANKYFMV
                     GHRVIFYVMMDDTSRMPAVHLSPLHSLQVFEIRSEKRWQDISMMRMKTIGEHILDHIQ
                     HEVDFLFCMDVDQVFQDNFGVETLGQLVAQLQAWWYKASPDEFTYERRELSAAYIPFG
                     EGDFYYHAAVFGGTPVHILNLTRECFKGILQDKKHDIEAQWHDESHLNKYFLFNKPTK
                     ILSPEYCWDYHIGLPSDIKNVKIAWQTKEYNLVRSNV"
     misc_feature    512..565
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3L7M0.2);
                     transmembrane region"
     misc_feature    647..1498
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    647..1498
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    order(800..808,815..817,992..994,1004..1006,1073..1081,
                     1475..1477,1481..1483,1493..1495)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(800..808,815..817,992..994,1004..1006,1073..1081,
                     1475..1477,1481..1483,1493..1495)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(800..808,815..817,1073..1081,1139..1150,1175..1177,
                     1232..1234,1340..1342,1349..1351)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     misc_feature    order(800..808,815..817,1073..1081,1139..1150,1175..1177,
                     1232..1234,1340..1342,1349..1351)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     misc_feature    1277..1279
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3L7M0.2); glycosylation site"
     exon            485..573
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            574..675
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            676..813
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            814..3402
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcccgc gccctaggcc gccgcgcgct gcccagagga ggcgccggca ggggccggag
       61 gcgcgcaccc cgcccggcac acccaggcgg agcagcgacc cggtctcctg cagcgcaggg
      121 cgccgcccgc gtgcgtggtc ctgtccccat cgcggccgac cgcacacgcc gggcctggtt
      181 ctgcagatca ggagttggag ccctgtacct tcctttcctc tgagccctgt ctccttcggc
      241 aggcgggagc tccatagaac tcggttgctc tgctgtttgc tttggagagg acacagcgga
      301 caatgaggtt gactatgaac tcaagagata tacttacccc agtctcctgg aattaaaggc
      361 ctgtaccgcc ttgcctggac ctaagattat catggttact atgcctcaag atctccacgt
      421 caaggtctcc atgtcaagat ccaagtcaga aacaagtctt ctatcctcaa gatctggatc
      481 acaggagaaa ataatgaatg tcaaggggaa aataatcctg tcggtgctga tggtctcaac
      541 cgtgcttgtc gtgttttggg aatatgtcaa caggacccac agttatcaag aagaggacat
      601 agagagagcg agagaaaagg ggagaaatgg agacagcatt gtagagcctc agctctggga
      661 ctggttcaat ccaaagaacc gcccggaggt tttgacggtg accccgtgga aggcgccgat
      721 tgtgtgggaa ggcacttacg acacagctct gttggaaaag tactatgcca gacagaaaat
      781 cactgtgggg ttgacagttt ttgctgtggg aaagtacatt gagcattact tagaagactt
      841 tctggagtct gctaacaagt acttcatggt cggccaccgg gtcatatttt acgtcatgat
      901 ggacgacacc tccagaatgc cggccgtcca tctgagtcct ctgcattcct tgcaagtgtt
      961 cgagatcagg tctgagaaga gatggcagga tataagcatg atgcggatga aaaccatcgg
     1021 ggagcacatc ctggaccaca tccagcacga ggttgacttc ctcttctgca tggacgtgga
     1081 ccaagtcttt caagacaact ttggtgtgga gaccctgggc cagttggtag ctcagctcca
     1141 ggcctggtgg tacaaggcca gccctgacga gtttacctat gagaggcggg aactctcggc
     1201 agcctacatt ccattcggag agggggattt ttactaccac gcggccgttt ttggaggaac
     1261 gcccgttcac attctgaacc tcaccaggga gtgctttaag gggatcctcc aggacaagaa
     1321 acatgacata gaagcccagt ggcatgacga gagccacctc aacaaatact tccttttcaa
     1381 caaacccact aaaatcctat ccccggagta ttgctgggac tatcatatag gcctgccctc
     1441 agatattaaa aatgtcaaga tagcttggca gacaaaagag tataatttgg tgagaagcaa
     1501 tgtctgactt caaacgtgat ggaaacctga caccattatt ctggtgaatc cctctaaaaa
     1561 gcagtaacac ttgatttcaa ctttaaaaaa aagtccccaa atcaaaaccc accaccatgg
     1621 catacacgta tgaattctcc ttataacctt gagccttgta atatgtgaga gggtctatgg
     1681 taagtaatca ggtataaatt ctcagtgatt ccttatatat tccgggtttt gggggtcata
     1741 ctaactaaat aagcaggaat ggaaattaat ttgcattagg taaagaagac acaagaacat
     1801 tctgtccagt gtgtcagata actcactata ggccagggtg ttgagagaag catttggcag
     1861 caggatgggt tgggtcagag ctagggggct ccgtcccctt ggtttcattg tcttcctcct
     1921 cttggagatt ctaaagaaac acagagaggt tttgcaacca gaggacttca ggaaggatac
     1981 caatgagatc gtcaaagtct ttaaatctga ctctggcttc caggagctgc tggcagtcca
     2041 ggccctgtgg tgcataatga aggcagagag tgccactagg tatcttggtg gcacatgttc
     2101 agagtcccag gaactatggg ggtgacaact atgctctggt ggagggacat agggtatggt
     2161 gttggtgtag ttacaaacac aggcaggttt ctcaacaacg accaacagca gggatcgaac
     2221 agaaagtgca ttttgtttta cccaaatcct gttcacattg ttagccttgt gtgtggagtc
     2281 ctgtggagag gggaggagag tacctcagtg gactgaggag aaggacccag tttttatcag
     2341 aaggcaatct gtcatcatct ggtcctacca tctgctctga acctcagagt tcctcagccc
     2401 accatgttct agtatggagg actgacacgg agccagtgac ggaagacaaa gccctccgtc
     2461 acatgacctc atgccttgtc tgcactatgc aagtatgaca gccagacaga tgtaccaggc
     2521 aacgtggtta actgacttca tggcgatggg agatgcagtc accacgacca agcagctgaa
     2581 ggttcagttc ccttctctga gagaagtgtg agagcctgtc tatgagtggt tcttaacctg
     2641 tgggtcgcga ccccttaggt atgaatgacc cttttcacag gggtcgccta cgaccattgg
     2701 aaagcacaga catttacatt atggtttgta acagtagcaa aattacagtt aatgaagtag
     2761 taacgaacat gattctgtgg ttgggggtaa cccgtatcgt gaggtcacag tatctgggaa
     2821 gcagagaacc atttctctat atgggtattt aagcaaataa gtcgatctgt atttctgtgt
     2881 acacatatat ttatattttg cttgtcttcc cgtctaggtc atcagtttct acctttaagc
     2941 catttattta aaaagctatt gcactgtctt ggtgaacagt gtgtggggct tcaataaaaa
     3001 agggtcttgt gcgtgtctac atggttccac ctcttactta aaaaaacaaa aaagtcgcat
     3061 atcccaaggc aacaaacccc acagaattcc cgaaccaatg ggcgttgcaa aaggaagtgg
     3121 agcctgcaca tctgttaaga attctgcctg tctatctctc accttgtgct agatccagtc
     3181 taaagtggga gggtttaatg gtcctgaacc aaagaaataa tcggttctga aagtgtaggg
     3241 gagaagacag aaggaatttg gagcgaattg atttttctaa ataaaaatgc atctacaatt
     3301 taaattccta atgagtaaat ttaggatttt attaaaggtg atgtttagac atttctaaaa
     3361 tatacattct ggtttacaat caaataaatt attttctcag ta
//
LOCUS       NM_001134956            6991 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus AT hook, DNA binding motif, containing 1 (Ahdc1),
            transcript variant 2, mRNA.
ACCESSION   NM_001134956 XM_017593517 XM_342936
VERSION     NM_001134956.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6991)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 27, 2025 this sequence version replaced
            XM_017593517.3, NM_001134956.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR21887621.101430.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760386, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  150512215-150512249
            36-167              JAXUCZ010000005.1  150512501-150512632
            168-262             JAXUCZ010000005.1  150512867-150512961
            263-444             JAXUCZ010000005.1  150555407-150555588
            445-675             JAXUCZ010000005.1  150561717-150561947
            676-713             JAXUCZ010000005.1  150562081-150562118
            714-5609            JAXUCZ010000005.1  150562477-150567372
            5610-6991           JAXUCZ010000005.1  150577423-150578804
FEATURES             Location/Qualifiers
     source          1..6991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6991
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="AT hook, DNA binding motif, containing 1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
     exon            1..35
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            36..167
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            168..262
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            263..444
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            445..675
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    623..625
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="upstream in-frame stop codon"
     exon            676..713
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            714..5609
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     CDS             788..5566
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="A.T hook DNA-binding motif-containing protein 1;
                     AT-hook DNA-binding motif-containing protein 1"
                     /codon_start=1
                     /product="transcription factor Gibbin"
                     /protein_id="NP_001128428.1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
                     /translation="MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPP
                     ASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPTPAP
                     DNNSLRHWDNGRVNLHPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPG
                     DLQYSFFSSPSLANSIRSPEERATPHAKPERPNHPLYEPEPEPRDSPQPGQGHGPGAT
                     ATATGLPPEPEPDGPDYPELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLD
                     PQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALD
                     PLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKIL
                     CRRRKAGRGRKVDSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPPALSGPVPELEPE
                     SSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLR
                     VSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAE
                     AAAVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQC
                     AGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKA
                     ARCSFSDFFEGIGKKKKVVAVAATGVVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRS
                     RKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFA
                     STGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASR
                     PESRKASGNYAGPPSSALPAQRGLATFPSRGAKGSPVAVGNSGAGTDPSFQPVLPSRQ
                     TFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAG
                     QSVFAPAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKA
                     SFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASAASSSSSSFQPSP
                     ENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHVSEPNVILDISNYTPQKVK
                     QQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASS
                     APGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQP
                     RGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQ
                     SRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPDLDSKHFPPLAHPP
                     TVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCR
                     DLPLGQPHYESPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHL
                     ASPPATPKADKEPLEMTRPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTA
                     YRYPGFMPQTHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL"
     misc_feature    <2555..2701
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <2555..2701
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <3353..3928
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3353..3928
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            5610..6991
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcagcg gcggcggcgg cggagacgga gagagctcgg agagcagaga aaggcagaga
       61 gagcgagaaa tagagacagg cagacaaaca gacagacaga cagagcggga gggagaaggg
      121 cggcggagga ggagcaggag gactacgcgg ggcgccttcc ctcccagccg ggcgcccgtg
      181 ttgctgtcgc cggcggaaga tagacgcccc ccgaaacccc tcgcttggct cggacccacg
      241 gagccggcag cccagcactc cgatgggagc ttgtctgatt gtctactcat cggcctggac
      301 cccagagcca acccagctga gtgagtgcag agggtcccag gtgaggggca ctgctcaggc
      361 ctgggcagcg actgccctgg agaagctgat ggtggtggag acagaccgtt cctgctgagt
      421 tgggcctcta cagtccctgc tcagccccta cctcacagga tcggtatgaa gaatcaaatg
      481 aagcaatgcc tggacagctt ccagcccagt gcctggcgtg cagtaggtgc tcactaaacc
      541 tgagctacgg tggtcctttc caggcgctgt ccacacccca aggcctgggc tcaggccgaa
      601 gttgctccac aataccctca gctgacagcc agcgactggc agagtcccca agcacggggg
      661 ccctctgttt accagagata tccagtgtga cagcccaggc ggcagagccg agggttctgg
      721 tcccggcctc tctcaccctc atgtcagccc cggccccgcc cggcggcccg aggaggacaa
      781 ggtcaggatg cgtgtgaagc cccagggcct ggttgtgact tccagtgccg tgtgcagctc
      841 tcctgactac ctccgagagc ccaagtacta ccccggcggc cccccaaccc cccggccctt
      901 gcttcccacc cgcccccctg ccagcccacc tgacaaggcc ttttccaccc ataccttctc
      961 cgagaaccca cgcccacccc cacgtcggga ccccagctcc cggcgtccac cagtccttgc
     1021 caagggagac gacctgctac cccctcgggc agcccggcct gtctcccagg cccactgtcc
     1081 cacaccggcc ccagacaaca actccctccg tcactgggac aacgggcgtg tgaacctgca
     1141 tccggtggtg cagctgattg acatcatgaa ggacctgaca cggctgtccc aggacctgca
     1201 gcacagtggt gtgcatctag actgcggcgg gctgcgactg agccgcccac ccgctccacc
     1261 gcccggcgac ctgcagtaca gcttcttctc ttcacccagc ctggccaata gcatccgcag
     1321 ccctgaggag cgtgcgaccc ctcacgccaa gccagagcgg cccaaccacc ccctctatga
     1381 acctgagccc gagcccaggg atagtcccca gcctggccaa ggccatggtc ctggagccac
     1441 agccacggcc actggtctgc ccccagagcc tgagccagat gggcctgact accctgagct
     1501 ggcagacgct gacatcctca gtgaacttgc ctcccttact tgccctgagg cccagctcct
     1561 ggaggctcaa gcccttgagc ctccttcacc acagcctgag ccgcagctcc tggaccccca
     1621 gccccgcttc ctagacccac aagcactaga gcctctagga gaaggtttgg aactaccacc
     1681 cctgcagcct cttgcggatc ctctgggact gccgagcttg actctgcagg ccctagacac
     1741 cctacctgac tccttggaat cccagctcct tgaccctcag gccctcgacc ccctgcccaa
     1801 gttgttggat gtccctggtc gacgtctaga gccccagcaa tccttgggac actgccaact
     1861 ggctgagccc ttacgcctgg acttgtgctc acctcatggt ccccctgggc ctgagggcca
     1921 ccccaagtac gccttgaggc gcactgatag gccaaagatc ctgtgtcgca ggcggaaagc
     1981 tggaagggga cggaaggtgg attcaggacc tgaaggtcgt ctgctgcctc ttcccatgcc
     2041 tacagggctg gcagctgccc tggctgaacc cccaccgctg cccccaccac caccacctcc
     2101 tgctctgtca ggcccagttc ctgaactgga gccagagtcc tctcaaactc caatggtccc
     2161 cacccgcaaa ggcaagtgca ggggagtgcg gcggatggtg gtgaagatgg caaagatccc
     2221 tgtgtcacta gggcggagga acaagaccac gtacaaagtt tcatccttga gcagcagtct
     2281 gagtgtggag ggcaaggagc tgggcctgag ggtgtcgtcg gagcccaccc cattgctgaa
     2341 gatgaaaaac aatggccgga atgtggtggt ggtcttcccg ccaggtgaga tgcctattat
     2401 tctcaagcga aagcgtggcc gccctcctaa gaacctgctg ctgggtcctg gcaaacccaa
     2461 agagccaaca gtggtagctg ccgaggctgc cgctgtgaca gcggccacca tggccatgcc
     2521 ggaggtgaag aaacggcggc ggaggaaaca aaagctggca tccccgcagc cgtcctacgc
     2581 agcagacgcc aatgacagta aggctgagta ttccgatgtc cttgccaagc tggccttttt
     2641 gaaccgccag agccagtgtg ctgggagatg ctcgccaccc cgatgctgga cacccagtga
     2701 gcctgagtca gtgcaccaag ccccggacac tcagagcatc tctcaattcc tgcaccgggt
     2761 gcagggcttc cggaggcgtg gaggcaagac aggaggcttt ggaggtaggg gcggaggcca
     2821 tgcagccaag gcagcccgct gttcctttag tgactttttt gagggcattg gcaagaaaaa
     2881 gaaggtggta gcagtggcag ctactggggt tgtgggtcct ggtctcactg agctggggca
     2941 tccacgcaaa aggggccgag gcgaggtaga tgctgtaact gggaaaccca agcgcaagag
     3001 gcggtcccgg aagaatggga ctctgttccc agagcaggtg cccagtggcc caggctttgg
     3061 ggaggccggt gctgagtggg ctggggacaa gggtggtggc tgggcccctc accatgggca
     3121 cccaggaggg caagctggcc gaaactgtgg tttccagggg acggaggcca gggcttttgc
     3181 ctccactggg ctggagagtg gggcttcagg ccgtggcagc tactatgctg gtgcaccctc
     3241 aggccagacg gagctcagcc aggaacgcca aaacctcttc actggctatt ttcggtccct
     3301 gcttgattca gatgactcct ctgacctctt ggactttgcc ctatcggcct ctcgcccaga
     3361 gtcccggaag gcatcgggca actatgcagg gcctccctcc agtgcgctgc ctgctcagcg
     3421 ggggcttgcc accttcccaa gccggggagc caagggtagc ccagtggcag tgggcaacag
     3481 tggagctggg acagacccct ccttccagcc tgtcctgcct tcccgtcaga cctttccacc
     3541 aggccgggca acaagctatg ggataacccc agccacttca gactgccgag cagctgagac
     3601 cttcccaaag ctggctcccc ctccttcagc tgtggcccgc tcgcctacaa cccaccctcc
     3661 tgccaacacc tacccacctc agtatggtgg ctatggggca ggacaaagtg tgtttgcccc
     3721 agcaaagccc ttttcaggcc aggactgtgc taatagtaag gactgcagct ttgcctatgg
     3781 cagcggcaat agccttcctg cctcacccag cagcgcccac agtgctggct atgccccgcc
     3841 gcctactggg ggtccctgtc taccgcccag caaggcctcc ttcttcaaca gctctgaggg
     3901 gggccccttc tctgggtcag ctcccacacc cttgcgctgt gacagtcgag ccagtactgt
     3961 ctcacccggt ggctacatgg tacccaaggg caccacagct tctgctgcct ctgcggcctc
     4021 ctcctcttcc tcttcctttc agccctcacc tgagaactgt cggcagtttg tgggggcttc
     4081 tcagtggcct ttccggcagg ggtatggagg cctggactgg gcctcggagg cctttagtca
     4141 gctctacaat cccaactttg actgccacgt cagtgaaccc aatgtgatct tggacatctc
     4201 gaactacacg ccacagaagg tgaagcagca gactgctgtg tccgagacct tctccgagtc
     4261 atcctctgac agcacccagt tcaatcagcc agttggtggt ggttttaggc gtgccaacag
     4321 tgaggcctca agcagtgagg gccagtcaag cctgtccagc ctggagaagc tcatgatgga
     4381 ctggaatgaa gcatcatctg ctcccggcta caactggaac cagagcgtcc tctttcagag
     4441 tagctcaaag cctggccgtg gccggcggaa gaaggtggac ctgtttgagg cctcacattt
     4501 gggcttttca acatccacct cagccactgc ctctgggtat ccgtccaaac ggagcaccgg
     4561 accccggcag cctcggggtg gccggggtag tggggcctgc tcagccaaga aggagagagg
     4621 tggtacagcg gccaaagcca agttcatccc caagccacaa ccagtgaatc cactgttcca
     4681 ggacagccca gaccttggcc tggactacta tagtggggac agcagcatgt caccactgcc
     4741 ctcccagtcg agagcctttg gtgtgggaga acgagatccc tgtgacttca tgggacctta
     4801 ctccatgaat ccatccacac cttctgatgg cacttttggc caaggcttcc actgtgactc
     4861 tcccagcctg ggtgctcctg accttgacag caagcatttc ccaccactgg cccacccacc
     4921 cacagtgttt gatgctggcc tgcagaaggc ctactcaccc acctgttcac cgacactagg
     4981 cttcaaggaa gagttgcggc caccaccttc aaagctgact gcctgtgagc ccctcaagca
     5041 tggtcttcag ggggctagcc tgagtcatgc agcccaggcc cacctgagct gccgggacct
     5101 accgctaggc cagcctcact atgagtcccc tagttgcaag ggtacagcct attggtaccc
     5161 accaggttca gctgcccgca gcccacctta tgaaggcaag gtgggttcag ggctgctggc
     5221 tgacttcctg ggcaggacgg aggctgtctg cctcagtgcc cctcacctgg ctagcccacc
     5281 agccacgccc aaggccgaca aggagccatt ggagatgacc cggcccccag gtccaccccg
     5341 tggccctgct gcagccactg ctggctatgg ctgcccactc cttagtgact taactctgtc
     5401 ccctgtgccg agggactcgc tgctgcccct gcaggacact gcctacaggt atccaggctt
     5461 tatgccgcag acacaccctg gcctgggtgg gggtcctaag agtggcttcc tggggcccat
     5521 ggcggaacct caccctgagg acacatttac cgtcacctcc ctgtagtacc aactgaagtg
     5581 ccgactggac cacgaggttt tgttcctggc tttcagaaga ccaatgccaa gacccctccc
     5641 agcgtccaca gcatcctctg gcaggagcgc ctgcccctct gcctcccacc tgccccttgc
     5701 accccttgca gccccatatc ccacccatga cccctccttg cccatctcct ccacgcagaa
     5761 gccgaaggtg agccctttct gcacaaaacc agcaattgta aatacttttt aaaatgtaca
     5821 aaacttaaaa acaaaacaca gttttagaaa aagacaaaaa aaaaaaagag agagagagcg
     5881 agagcgagag agagagcgtg tgcaagaggt tgtgagtggg gcttcgaggt gtccagagcc
     5941 cctgcaagtg tgcactgaga aatttatcta caggtcgttt gacaaaaatg aacaatatcc
     6001 tatttattgt atatactgtt ttattataaa ttgtggattg tatattgcat tctgtaaacc
     6061 tgctgtggtc ccgtggtgtg caaattcgca tggtgggggg ggagggagaa cctcttttgg
     6121 gggctttttt tttttttttc tttttttttt ttttcctttt tcactcttgg gttttctctt
     6181 ctgttgctgt tgttgttttt tgttggcagg acacacccaa agatccaagt ttgtattaaa
     6241 aagaaatgaa gaaaagcaaa aaaaaaaaaa aaaaaaaaaa aaaaccaact tgtgtctgta
     6301 aaacagggta catgagggtg ggtgggactg tactggtgat gtcagcctct ggtccttctg
     6361 ggagttgaag tacctcagga tgttcctggt ttccctacct ctgagtcctc tcatctgcct
     6421 agtgtctcgg tgtcatctcc gtcccccacc agactccgag tgttttgccc acatgtatgt
     6481 ttgtgcacag catgtgtgag ttggtgccct tgaaggtcag aaaagggcat ggaatccccg
     6541 ttacagacag ctataagctg tcattccgat gctgggactc aaatccatgt cctatgcaag
     6601 aacagtgagt gttctcaaca tcagaaacat tgcgttgact cgtccccgct cctgtcctac
     6661 atcccgtggc tcccacagat gctttctttt gcctgaagag tcccatggta agtttggtca
     6721 ccatcttctt cctctcgatg ccctcagtcc acctcaggtc ccagagcacc accccgacgt
     6781 ctgtttgtcc tgtctccctg accattaagg ctccagactt ctatcatggt cctaagaggc
     6841 cgatcttcat tttactgagg cagagtgtct ctgtgtggcc ccagctatcc tagaacttgt
     6901 atgtagtatg taaaccaggc tgaccagact cagacctgcc tgcctcatct tccgagaact
     6961 gggattacac atgtgccact gcacccagca a
//
LOCUS       NM_001437133            3225 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus glycoprotein alpha-galactosyltransferase 1
            (Ggta1), transcript variant 3, mRNA.
ACCESSION   NM_001437133 XM_008761702
VERSION     NM_001437133.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 27, 2025 this sequence version replaced XM_008761702.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.7719.1,
                                           SRR26643299.13694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000003.1  39207771-39207961   c
            192-307             JAXUCZ010000003.1  39167649-39167764   c
            308-396             JAXUCZ010000003.1  39151586-39151674   c
            397-498             JAXUCZ010000003.1  39144883-39144984   c
            499-636             JAXUCZ010000003.1  39137701-39137838   c
            637-3225            JAXUCZ010000003.1  39130466-39133054   c
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3225
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="glycoprotein alpha-galactosyltransferase 1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     exon            1..191
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            192..307
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="upstream in-frame stop codon"
     exon            308..396
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1330
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /EC_number="2.4.1.87"
                     /note="isoform 2 is encoded by transcript variant 3;
                     glycoprotein galactosyltransferase alpha 1, 3;
                     N-acetyllactosaminide alpha-1,3-galactosyltransferase;
                     glycoprotein, alpha-galactosyltransferase 1,3;
                     UDP-galactose:beta-D-galactosyl-1,
                     4-N-acetyl-D-glucosaminide
                     alpha-1,3-galactosyltransferase"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     alpha-1,3-galactosyltransferase isoform 2"
                     /protein_id="NP_001424062.1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
                     /translation="MNVKGKIILSVLMVSTVLVVFWEYVNRTHSYQEEDIERAREKGR
                     NGDSIVEPQLWDWFNPKNRPEVLTVTPWKAPIVWEGTYDTALLEKYYARQKITVGLTV
                     FAVGKYIEHYLEDFLESANKYFMVGHRVIFYVMMDDTSRMPAVHLSPLHSLQVFEIRS
                     EKRWQDISMMRMKTIGEHILDHIQHEVDFLFCMDVDQVFQDNFGVETLGQLVAQLQAW
                     WYKASPDEFTYERRELSAAYIPFGEGDFYYHAAVFGGTPVHILNLTRECFKGILQDKK
                     HDIEAQWHDESHLNKYFLFNKPTKILSPEYCWDYHIGLPSDIKNVKIAWQTKEYNLVR
                     SNV"
     misc_feature    470..1321
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    470..1321
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="Glycosyltransferase family 6; Region:
                     Glyco_transf_6; pfam03414"
                     /db_xref="CDD:427285"
     misc_feature    order(623..631,638..640,815..817,827..829,896..904,
                     1298..1300,1304..1306,1316..1318)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(623..631,638..640,815..817,827..829,896..904,
                     1298..1300,1304..1306,1316..1318)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133008"
     misc_feature    order(623..631,638..640,896..904,962..973,998..1000,
                     1055..1057,1163..1165,1172..1174)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     misc_feature    order(623..631,638..640,896..904,962..973,998..1000,
                     1055..1057,1163..1165,1172..1174)
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="active site"
                     /db_xref="CDD:133008"
     exon            397..498
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            499..636
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            637..3225
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcccgc gccctaggcc gccgcgcgct gcccagagga ggcgccggca ggggccggag
       61 gcgcgcaccc cgcccggcac acccaggcgg agcagcgacc cggtctcctg cagcgcaggg
      121 cgccgcccgc gtgcgtggtc ctgtccccat cgcggccgac cgcacacgcc gggcctggtt
      181 ctgcagatca ggagttggag ccctgtacct tcctttcctc tgagccctgt ctccttcggc
      241 aggcgggagc tccatagaac tcggttgctc tgctgtttgc tttggagagg acacagcgga
      301 caatgaggag aaaataatga atgtcaaggg gaaaataatc ctgtcggtgc tgatggtctc
      361 aaccgtgctt gtcgtgtttt gggaatatgt caacaggacc cacagttatc aagaagagga
      421 catagagaga gcgagagaaa aggggagaaa tggagacagc attgtagagc ctcagctctg
      481 ggactggttc aatccaaaga accgcccgga ggttttgacg gtgaccccgt ggaaggcgcc
      541 gattgtgtgg gaaggcactt acgacacagc tctgttggaa aagtactatg ccagacagaa
      601 aatcactgtg gggttgacag tttttgctgt gggaaagtac attgagcatt acttagaaga
      661 ctttctggag tctgctaaca agtacttcat ggtcggccac cgggtcatat tttacgtcat
      721 gatggacgac acctccagaa tgccggccgt ccatctgagt cctctgcatt ccttgcaagt
      781 gttcgagatc aggtctgaga agagatggca ggatataagc atgatgcgga tgaaaaccat
      841 cggggagcac atcctggacc acatccagca cgaggttgac ttcctcttct gcatggacgt
      901 ggaccaagtc tttcaagaca actttggtgt ggagaccctg ggccagttgg tagctcagct
      961 ccaggcctgg tggtacaagg ccagccctga cgagtttacc tatgagaggc gggaactctc
     1021 ggcagcctac attccattcg gagaggggga tttttactac cacgcggccg tttttggagg
     1081 aacgcccgtt cacattctga acctcaccag ggagtgcttt aaggggatcc tccaggacaa
     1141 gaaacatgac atagaagccc agtggcatga cgagagccac ctcaacaaat acttcctttt
     1201 caacaaaccc actaaaatcc tatccccgga gtattgctgg gactatcata taggcctgcc
     1261 ctcagatatt aaaaatgtca agatagcttg gcagacaaaa gagtataatt tggtgagaag
     1321 caatgtctga cttcaaacgt gatggaaacc tgacaccatt attctggtga atccctctaa
     1381 aaagcagtaa cacttgattt caactttaaa aaaaagtccc caaatcaaaa cccaccacca
     1441 tggcatacac gtatgaattc tccttataac cttgagcctt gtaatatgtg agagggtcta
     1501 tggtaagtaa tcaggtataa attctcagtg attccttata tattccgggt tttgggggtc
     1561 atactaacta aataagcagg aatggaaatt aatttgcatt aggtaaagaa gacacaagaa
     1621 cattctgtcc agtgtgtcag ataactcact ataggccagg gtgttgagag aagcatttgg
     1681 cagcaggatg ggttgggtca gagctagggg gctccgtccc cttggtttca ttgtcttcct
     1741 cctcttggag attctaaaga aacacagaga ggttttgcaa ccagaggact tcaggaagga
     1801 taccaatgag atcgtcaaag tctttaaatc tgactctggc ttccaggagc tgctggcagt
     1861 ccaggccctg tggtgcataa tgaaggcaga gagtgccact aggtatcttg gtggcacatg
     1921 ttcagagtcc caggaactat gggggtgaca actatgctct ggtggaggga catagggtat
     1981 ggtgttggtg tagttacaaa cacaggcagg tttctcaaca acgaccaaca gcagggatcg
     2041 aacagaaagt gcattttgtt ttacccaaat cctgttcaca ttgttagcct tgtgtgtgga
     2101 gtcctgtgga gaggggagga gagtacctca gtggactgag gagaaggacc cagtttttat
     2161 cagaaggcaa tctgtcatca tctggtccta ccatctgctc tgaacctcag agttcctcag
     2221 cccaccatgt tctagtatgg aggactgaca cggagccagt gacggaagac aaagccctcc
     2281 gtcacatgac ctcatgcctt gtctgcacta tgcaagtatg acagccagac agatgtacca
     2341 ggcaacgtgg ttaactgact tcatggcgat gggagatgca gtcaccacga ccaagcagct
     2401 gaaggttcag ttcccttctc tgagagaagt gtgagagcct gtctatgagt ggttcttaac
     2461 ctgtgggtcg cgacccctta ggtatgaatg acccttttca caggggtcgc ctacgaccat
     2521 tggaaagcac agacatttac attatggttt gtaacagtag caaaattaca gttaatgaag
     2581 tagtaacgaa catgattctg tggttggggg taacccgtat cgtgaggtca cagtatctgg
     2641 gaagcagaga accatttctc tatatgggta tttaagcaaa taagtcgatc tgtatttctg
     2701 tgtacacata tatttatatt ttgcttgtct tcccgtctag gtcatcagtt tctaccttta
     2761 agccatttat ttaaaaagct attgcactgt cttggtgaac agtgtgtggg gcttcaataa
     2821 aaaagggtct tgtgcgtgtc tacatggttc cacctcttac ttaaaaaaac aaaaaagtcg
     2881 catatcccaa ggcaacaaac cccacagaat tcccgaacca atgggcgttg caaaaggaag
     2941 tggagcctgc acatctgtta agaattctgc ctgtctatct ctcaccttgt gctagatcca
     3001 gtctaaagtg ggagggttta atggtcctga accaaagaaa taatcggttc tgaaagtgta
     3061 ggggagaaga cagaaggaat ttggagcgaa ttgatttttc taaataaaaa tgcatctaca
     3121 atttaaattc ctaatgagta aatttaggat tttattaaag gtgatgttta gacatttcta
     3181 aaatatacat tctggtttac aatcaaataa attattttct cagta
//
LOCUS       NM_001437157            3859 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 4, mRNA.
ACCESSION   NM_001437157 XM_006239250
VERSION     NM_001437157.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3859)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3859)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3859)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3859)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3859)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3859)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3859)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3859)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006239250.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29949.1,
                                           SRR26643284.8281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1901           JAXUCZ010000005.1  158589800-158590006
            1902-1991           JAXUCZ010000005.1  158590386-158590475
            1992-2151           JAXUCZ010000005.1  158590555-158590714
            2152-2272           JAXUCZ010000005.1  158590833-158590953
            2273-2397           JAXUCZ010000005.1  158591073-158591197
            2398-2558           JAXUCZ010000005.1  158591857-158592017
            2559-2675           JAXUCZ010000005.1  158592132-158592248
            2676-2755           JAXUCZ010000005.1  158592331-158592410
            2756-2908           JAXUCZ010000005.1  158592944-158593096
            2909-3005           JAXUCZ010000005.1  158593200-158593296
            3006-3229           JAXUCZ010000005.1  158593909-158594132
            3230-3381           JAXUCZ010000005.1  158594217-158594368
            3382-3477           JAXUCZ010000005.1  158594595-158594690
            3478-3859           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3859
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3527
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 4 is encoded by transcript variant 4;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 4"
                     /protein_id="NP_001424086.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLV
                     CELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR
                     EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMS
                     RTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVP
                     APDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGATRTEEHCGQLFQVAA
                     AGSGRLQLCGRLHAGERAGPVSPSLPAVAAA"
     misc_feature    282..3380
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3380
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1901
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2397
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2558
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2675
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2755
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2908
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3005
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3229
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3381
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3477
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3859
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caagacaggc accctcacgg aggacggatt ggacataatg ggggtggtgc
     1741 ccctaaaggg gcagatgttg ctgccactgg tcccagagcc ctgccacctg cccccagggc
     1801 ccctcctccg agcactggtc acctgtcatg ccctcagcca gctacatgat accttggtgg
     1861 gcgaccccat ggatctcaag atggtggagt ctacaggctg ggtcttagag gagggttcgg
     1921 ctgcaggctc agcacctgag acccaggtct tggtggtaat gcgaccccca cccagggggc
     1981 ctcagcaaca ggaagagtca ccagagccag tcagtgtcct ccgccgcttc cccttctcct
     2041 ctgccctgca gcggatggac gtggtggtga catggccagg ggccacccag cctgaggcct
     2101 acgtcaaagg ttccccagag cttgtggcca gcctctgcag ccccgagaca gtgcccagag
     2161 actttcctca ggtactgcag agctacacag ctgctggcta ccgagttgtg gccctggctg
     2221 gcaagccact gcccactgcg cccagccttg aggccgctca gcagctgaca agggacactg
     2281 tggagcagga gctgagcctc ctggggctgc tggtcatgcg gaacctgctg aagccacaga
     2341 cgaccccagt tatacagacc ctgaggaaga cgggcatccg tactgttatg gtgacagggg
     2401 acaacctgca gacagcagtc acggtggcca aagcgtgtgg catggtgggc acccaggagc
     2461 acctggctat catccatgcc acccaccctg agcagggcca gcctgctgcc cttgagttcc
     2521 tgccaactga gccctctgcg gccatgaatg gggcaaagga tcctgtgcag gccacggact
     2581 accccgtgga gccggagtcc cagtcccgtc acctggccct cagtgggtcc acgtttgctg
     2641 tccttcagaa gcacttcccc aagctgctgc ccaaggtcct ggtgcaggcc accgtctttg
     2701 cccgcatggc cccggagcag aagacacagc tagtgtgtga acttcagaga cttcagtact
     2761 gcgtgggcat gtgcggggat ggagccaatg actgtggggc cctgaaggcg gctgacgtgg
     2821 gcatctcact gtcccaggca gaggcctcag tggtctctcc gttcacctcc agcatggcca
     2881 gtattgaatg tgtgcccact gtcatcaggg aaggccgctg ctctctggac acttcattca
     2941 gcgtcttcaa gtatatggcc ctatacagcc tgacccagtt catctctgtc ctcattctct
     3001 acacaatcaa caccaacctg ggagacctac agttcttggc catcgacctg ttcatcacca
     3061 ccacggttgc cgtgctcatg agccgcaccg gccctgcact gaccttggtg cgagcacggc
     3121 caccaggggc gctgctgagc gtgcctgtac ttggcagttt gctgctgcag gtggccttgg
     3181 tggccggcat ccagcttggg ggctactttt tggtcatagc tcagccctgg tttgtgcctc
     3241 tgaacagaac tgtacccgca cctgacaacc tgcccaacta cgagaacaca gtgatcttct
     3301 ctctgtctgg cttccagtac ctcatcctgg ccgcagcggt gtctaagggg gcacccttcc
     3361 gccagccgct ctacaccaac ggggccacta ggactgagga acattgcgga cagctctttc
     3421 aagttgctgc tgctgggtct ggtcgccttc aactttgtgg gcgccttcat gctggagagc
     3481 gtgctggacc agtgtctccc agcctgcctg cagtggctgc ggcctaaacg ggcctccaag
     3541 aagcaattca agcagctaca acgggagctt gctgaacgtc catggcccac tctgcccgtt
     3601 ggctccgtga ggtagtgcag gccttggagg gcatgctgga cactggatct ccctgcccct
     3661 gagccatgac cggaactctc cctagagaca gtaccagtca cctcccacag ccctgaggtt
     3721 ggctgtcaca ctcctgggga cacactcgcc tggggaggcg ttgattgttg cctcactgtg
     3781 tagagacagc agctaccaac tccatccgga gcagctgtca tggagcaaat aaagtgccgg
     3841 ctttcctgtc ttggcagca
//
LOCUS       NM_001437146             822 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 2, mRNA.
ACCESSION   NM_001437146
VERSION     NM_001437146.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.251610.1,
                                           SRR26360190.1447954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093046, SAMN17050749
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  20594710-20594770
            62-134              JAXUCZ010000008.1  20627478-20627550
            135-822             JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..822
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..61
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            62..134
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            135..822
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..395
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424075.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    216..380
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    216..380
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 agaggcgagg cgggcgagcg gctgcccctg ccacgtaccc ggccgtgcgc ggcggcggca
       61 gaactcaggt caccctgact ggaaatcagt tgacccacgt cagtgaagca gtggttcctg
      121 aatttgaaga aaagaggtgg tctgcccgga cagaggagtg tggccctttc ttcaagccct
      181 ctctgcacat ctcttcccag catcctctaa ccaagatgcg tcagctcaaa gggaagccaa
      241 agaaagagac ctccaaggac aagaaggagc ggaagcaggc catgcaggag gcccggcagc
      301 agatcaccac tgtggtgctg cctaccttgg ctgtggtggt gctcctcatt gtagtgtttg
      361 tgtacgtggc cacgcgcccc atcgtcaccg agtgagcacc gccatcctgg ctttcctctg
      421 cagacatgtc tgcaatgccg agctctgggc aggagtgccc tgtctcctct gatctttgac
      481 ttgatcaata tttctctact tttggggggg aagggaaagg gaacatttat cagtgaatgt
      541 gccatttacc cgatggtcca cttcatgtgc ctttcagact tcaaagcagt gcgtgtgtgc
      601 gtgtgcgtgt gcgtgtgtgc gtgcgtgtct ccccttttct cctgaaatcg acgcacagct
      661 gcacctgggg agaggaggcc tctccgggtg acactgtgct tcctggctcc gttcacagct
      721 ttctaagggg acagcctttc ttctctgtac ttgatgggat gtgaaatacg ctgactcaaa
      781 gtgaaatatt tatttttgaa taaaggagat aatagtctta aa
//
LOCUS       NM_001109447            1964 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus galactose-3-O-sulfotransferase 1 (Gal3st1),
            transcript variant 1, mRNA.
ACCESSION   NM_001109447 XM_001067165
VERSION     NM_001109447.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Honke,K., Hirahara,Y., Dupree,J., Suzuki,K., Popko,B.,
            Fukushima,K., Fukushima,J., Nagasawa,T., Yoshida,N., Wada,Y. and
            Taniguchi,N.
  TITLE     Paranodal junction formation and spermatogenesis require
            sulfoglycolipids
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4227-4232 (2002)
   PUBMED   11917099
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Hirahara,Y., Tsuda,M., Wada,Y. and Honke,K.
  TITLE     cDNA cloning, genomic cloning, and tissue-specific regulation of
            mouse cerebroside sulfotransferase
  JOURNAL   Eur J Biochem 267 (7), 1909-1917 (2000)
   PUBMED   10727929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2025 this sequence version replaced NM_001109447.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360194.1412120.1, SRR26360190.409382.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000014.1  83094293-83094481
            190-410             JAXUCZ010000014.1  83095651-83095871
            411-553             JAXUCZ010000014.1  83107587-83107729
            554-1964            JAXUCZ010000014.1  83108582-83109992
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1964
                     /gene="Gal3st1"
                     /note="galactose-3-O-sulfotransferase 1"
                     /db_xref="GeneID:683713"
                     /db_xref="RGD:1583379"
     exon            1..189
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..410
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    267..269
                     /gene="Gal3st1"
                     /note="upstream in-frame stop codon"
     misc_feature    327..329
                     /gene="Gal3st1"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MRDDREGMAEWSRSSPKGYQIGDLWNHQWFPE"
     misc_feature    348..350
                     /gene="Gal3st1"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MAEWSRSSPKGYQIGDLWNHQWFPE"
     exon            411..553
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1694
                     /gene="Gal3st1"
                     /EC_number="2.8.2.11"
                     /codon_start=1
                     /product="galactosylceramide sulfotransferase"
                     /protein_id="NP_001102917.2"
                     /db_xref="GeneID:683713"
                     /db_xref="RGD:1583379"
                     /translation="MTLLPKKPCKSKAKGLVLGALLTSFLLLLYSYVVPPLYPNLAFT
                     TSEAAAPCSPVPNEPVAATPANGSAGGCQPRRDIVFMKTHKTASSTLLNILFRFGQKH
                     ELKFAFPNGRNDFHYPSYFARSLVQDYRPGACFNIICNHMRFHYEEVRGLVRPGATFI
                     TVIRDPARLFESSFHYFGSVVPLTWKLSSRDKLAEFLQDPDRYYDPSSYNAHYLRNLL
                     FFDLGYDSSLDPGSPRVQEHILEVERRFHLVLLQEYFDESLVLLRELLCWDLEDVLYF
                     KLNARRDSPEPRLSGELYRRATAWNLLDVRLYRHFNASFWRKVEAFGRERMASEVAKL
                     RRANEHMRSICIDGGQAVDAEAIQDSAMQPWQPLGIKSILGYNLKKSIGPQHEQLCRR
                     MLTPEIQYLSDLGANLWITKLWKFFRDFLRW"
     misc_feature    432..1646
                     /gene="Gal3st1"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     cl22970"
                     /db_xref="CDD:451469"
     misc_feature    432..1646
                     /gene="Gal3st1"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     cl22970"
                     /db_xref="CDD:451469"
     exon            554..1964
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggcctca cctggccgag agtattgaga acgggtgcgg cagccgctgc ggcggcgggg
       61 cgggggcatg gaccaggcct gccagcgcgc cgggtcccgg cgagtgcgcc ccgccgccca
      121 gtgagcgcca cggcggcggg ggccgggacc gacccctgcc acccggagcc caaggagaac
      181 agggccaagt acctctctct gagctctaag gaagagtaaa caaacctgtg tgggagagca
      241 gtgattcact cagaatggcc cacaaatagt gggactctag gccctatctg tggcttgtga
      301 caagcttctt gctttggttc tactccatga gagatgatag agagggcatg gcagaatgga
      361 gcagaagctc ccccaaaggt taccagattg gagacctctg gaatcatcag tggtttcctg
      421 agatgactct actgccgaag aagccctgca agtccaaggc caaggggcta gtgctggggg
      481 ctctcttaac cagtttccta ttgctgctgt actcctatgt ggtacctcca ctgtatccca
      541 acttggcctt cacgacctca gaggctgcag cgccctgctc ccctgtcccc aatgagccag
      601 tggcagccac tcccgccaac ggctctgccg gagggtgcca acctcggcgg gatattgtgt
      661 tcatgaagac gcacaagacc gccagcagca cgctgctcaa catcctcttc cgcttcggcc
      721 agaagcatga gctcaagttc gccttcccca atggccgcaa cgacttccac tacccatcgt
      781 acttcgcacg aagcctggtg caggactacc ggccaggggc atgcttcaat atcatctgca
      841 accacatgcg cttccactac gaggaggtgc gcgggctggt gcggccgggt gctaccttca
      901 tcacggtcat ccgcgacccc gctcgtctct tcgagtcctc cttccactac tttgggtccg
      961 tggtgccgct cacttggaag ctgtcgagtc gcgacaagct ggctgagttc ctgcaggatc
     1021 ccgatcgcta ctacgaccca agcagctaca acgcgcacta cctccgtaac ctgctcttct
     1081 tcgacctggg ctacgacagc agcctggatc cgggcagccc gcgcgtgcag gagcacatcc
     1141 tggaggtgga gcgccgcttc cacctggtgc tgctgcagga gtacttcgac gaatccctgg
     1201 tgctgctccg ggagctgctg tgctgggacc tggaggacgt gctgtacttc aagctcaacg
     1261 cgaggcgcga ctcgccggag ccgcggctct caggcgagct gtaccgccga gccaccgcct
     1321 ggaacctgct ggatgtgcgt ctctaccgcc acttcaacgc cagcttctgg cgaaaggtgg
     1381 aggccttcgg gcgcgagcgc atggcgagcg aggtagccaa gctgcgccga gctaacgagc
     1441 acatgcgcag catctgcata gatggcggcc aagcggttga tgcggaggcc atccaggact
     1501 ccgccatgca gccctggcag cccctgggca tcaagtccat cctgggttac aacctcaaga
     1561 agagcatcgg gccacaacac gagcagctct gccggcgcat gctcacgccc gagatccagt
     1621 acctgtctga ccttggtgcc aatctctgga tcaccaagct ctggaagttc tttagggact
     1681 ttctaagatg gtgatgtact cggcccacct cctgtttggc ttcctactgc agaaaggccg
     1741 ggcagggaaa ctttggcacc tagccctccc cagccacgcc tagtgccatc tggggtccct
     1801 agggtcatag ctatccgaga ctggtctctc tgcacgagag ggcctaactg agaggtattt
     1861 aactaattat ggcattttaa aaaaatttaa atccccttta tctccagcct ctacttacaa
     1921 ggggagactc agaagtaaag aaattttatg cgtttttttg ttaa
//
LOCUS       NM_001437151            1084 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 6, mRNA.
ACCESSION   NM_001437151 XM_039081705
VERSION     NM_001437151.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039081705.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.467054.1,
                                           SRR22582416.1266474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               JAXUCZ010000008.1  20594935-20595253
            320-396             JAXUCZ010000008.1  20627474-20627550
            397-1084            JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..1084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..1084
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..319
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            320..396
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            397..1084
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..657
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424080.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    478..642
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    478..642
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 ggcctcgggg gccgagcggg aagtgcggcg tgggcggctg aggccccgtg cgggaaggcg
       61 gccccgcggg gacacgcggg aacacgcgcg gtccgcagag gggcgcgcgt ttgcaggtgg
      121 aggcgggtgg ccgaggaacc cagcggggcg gcggggagcg gctggcctct tccctgctgc
      181 ggcccagggg gccggcggag agtggtggtg gtggccctcg tggcattcgg ggtccccgtg
      241 gggaaggagc tgagcgtggt ttcctgcgtc gcgggctcca ggaccgcccc tcccagtgcc
      301 tcattcacct cacactgcgg aagaactcag gtcaccctga ctggaaatca gttgacccac
      361 gtcagtgaag cagtggttcc tgaatttgaa gaaaagaggt ggtctgcccg gacagaggag
      421 tgtggccctt tcttcaagcc ctctctgcac atctcttccc agcatcctct aaccaagatg
      481 cgtcagctca aagggaagcc aaagaaagag acctccaagg acaagaagga gcggaagcag
      541 gccatgcagg aggcccggca gcagatcacc actgtggtgc tgcctacctt ggctgtggtg
      601 gtgctcctca ttgtagtgtt tgtgtacgtg gccacgcgcc ccatcgtcac cgagtgagca
      661 ccgccatcct ggctttcctc tgcagacatg tctgcaatgc cgagctctgg gcaggagtgc
      721 cctgtctcct ctgatctttg acttgatcaa tatttctcta cttttggggg ggaagggaaa
      781 gggaacattt atcagtgaat gtgccattta cccgatggtc cacttcatgt gcctttcaga
      841 cttcaaagca gtgcgtgtgt gcgtgtgcgt gtgcgtgtgt gcgtgcgtgt ctcccctttt
      901 ctcctgaaat cgacgcacag ctgcacctgg ggagaggagg cctctccggg tgacactgtg
      961 cttcctggct ccgttcacag ctttctaagg ggacagcctt tcttctctgt acttgatggg
     1021 atgtgaaata cgctgactca aagtgaaata tttatttttg aataaaggag ataatagtct
     1081 taaa
//
LOCUS       NM_001437113            6875 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus AT hook, DNA binding motif, containing 1 (Ahdc1),
            transcript variant 4, mRNA.
ACCESSION   NM_001437113 XM_039110397
VERSION     NM_001437113.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6875)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039110397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.24680.1,
                                           SRR26643289.16421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  150512215-150512249
            36-167              JAXUCZ010000005.1  150512501-150512632
            168-265             JAXUCZ010000005.1  150512864-150512961
            266-447             JAXUCZ010000005.1  150555407-150555588
            448-559             JAXUCZ010000005.1  150561836-150561947
            560-597             JAXUCZ010000005.1  150562081-150562118
            598-5493            JAXUCZ010000005.1  150562477-150567372
            5494-6875           JAXUCZ010000005.1  150577423-150578804
FEATURES             Location/Qualifiers
     source          1..6875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6875
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="AT hook, DNA binding motif, containing 1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
     exon            1..35
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            36..167
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            168..265
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            266..447
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            448..559
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    507..509
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="upstream in-frame stop codon"
     exon            560..597
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            598..5493
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     CDS             672..5450
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="A.T hook DNA-binding motif-containing protein 1;
                     AT-hook DNA-binding motif-containing protein 1"
                     /codon_start=1
                     /product="transcription factor Gibbin"
                     /protein_id="NP_001424042.1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
                     /translation="MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPP
                     ASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPTPAP
                     DNNSLRHWDNGRVNLHPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPG
                     DLQYSFFSSPSLANSIRSPEERATPHAKPERPNHPLYEPEPEPRDSPQPGQGHGPGAT
                     ATATGLPPEPEPDGPDYPELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLD
                     PQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALD
                     PLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKIL
                     CRRRKAGRGRKVDSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPPALSGPVPELEPE
                     SSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLR
                     VSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAE
                     AAAVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQC
                     AGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKA
                     ARCSFSDFFEGIGKKKKVVAVAATGVVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRS
                     RKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFA
                     STGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASR
                     PESRKASGNYAGPPSSALPAQRGLATFPSRGAKGSPVAVGNSGAGTDPSFQPVLPSRQ
                     TFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAG
                     QSVFAPAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKA
                     SFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASAASSSSSSFQPSP
                     ENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHVSEPNVILDISNYTPQKVK
                     QQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASS
                     APGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQP
                     RGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQ
                     SRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPDLDSKHFPPLAHPP
                     TVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCR
                     DLPLGQPHYESPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHL
                     ASPPATPKADKEPLEMTRPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTA
                     YRYPGFMPQTHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL"
     misc_feature    <2439..2585
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <2439..2585
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <3237..3812
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3237..3812
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            5494..6875
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcagcg gcggcggcgg cggagacgga gagagctcgg agagcagaga aaggcagaga
       61 gagcgagaaa tagagacagg cagacaaaca gacagacaga cagagcggga gggagaaggg
      121 cggcggagga ggagcaggag gactacgcgg ggcgccttcc ctcccagcag ccgggcgccc
      181 gtgttgctgt cgccggcgga agatagacgc cccccgaaac ccctcgcttg gctcggaccc
      241 acggagccgg cagcccagca ctccgatggg agcttgtctg attgtctact catcggcctg
      301 gaccccagag ccaacccagc tgagtgagtg cagagggtcc caggtgaggg gcactgctca
      361 ggcctgggca gcgactgccc tggagaagct gatggtggtg gagacagacc gttcctgctg
      421 agttgggcct ctacagtccc tgctcaggcg ctgtccacac cccaaggcct gggctcaggc
      481 cgaagttgct ccacaatacc ctcagctgac agccagcgac tggcagagtc cccaagcacg
      541 ggggccctct gtttaccaga gatatccagt gtgacagccc aggcggcaga gccgagggtt
      601 ctggtcccgg cctctctcac cctcatgtca gccccggccc cgcccggcgg cccgaggagg
      661 acaaggtcag gatgcgtgtg aagccccagg gcctggttgt gacttccagt gccgtgtgca
      721 gctctcctga ctacctccga gagcccaagt actaccccgg cggcccccca accccccggc
      781 ccttgcttcc cacccgcccc cctgccagcc cacctgacaa ggccttttcc acccatacct
      841 tctccgagaa cccacgccca cccccacgtc gggaccccag ctcccggcgt ccaccagtcc
      901 ttgccaaggg agacgacctg ctaccccctc gggcagcccg gcctgtctcc caggcccact
      961 gtcccacacc ggccccagac aacaactccc tccgtcactg ggacaacggg cgtgtgaacc
     1021 tgcatccggt ggtgcagctg attgacatca tgaaggacct gacacggctg tcccaggacc
     1081 tgcagcacag tggtgtgcat ctagactgcg gcgggctgcg actgagccgc ccacccgctc
     1141 caccgcccgg cgacctgcag tacagcttct tctcttcacc cagcctggcc aatagcatcc
     1201 gcagccctga ggagcgtgcg acccctcacg ccaagccaga gcggcccaac caccccctct
     1261 atgaacctga gcccgagccc agggatagtc cccagcctgg ccaaggccat ggtcctggag
     1321 ccacagccac ggccactggt ctgcccccag agcctgagcc agatgggcct gactaccctg
     1381 agctggcaga cgctgacatc ctcagtgaac ttgcctccct tacttgccct gaggcccagc
     1441 tcctggaggc tcaagccctt gagcctcctt caccacagcc tgagccgcag ctcctggacc
     1501 cccagccccg cttcctagac ccacaagcac tagagcctct aggagaaggt ttggaactac
     1561 cacccctgca gcctcttgcg gatcctctgg gactgccgag cttgactctg caggccctag
     1621 acaccctacc tgactccttg gaatcccagc tccttgaccc tcaggccctc gaccccctgc
     1681 ccaagttgtt ggatgtccct ggtcgacgtc tagagcccca gcaatccttg ggacactgcc
     1741 aactggctga gcccttacgc ctggacttgt gctcacctca tggtccccct gggcctgagg
     1801 gccaccccaa gtacgccttg aggcgcactg ataggccaaa gatcctgtgt cgcaggcgga
     1861 aagctggaag gggacggaag gtggattcag gacctgaagg tcgtctgctg cctcttccca
     1921 tgcctacagg gctggcagct gccctggctg aacccccacc gctgccccca ccaccaccac
     1981 ctcctgctct gtcaggccca gttcctgaac tggagccaga gtcctctcaa actccaatgg
     2041 tccccacccg caaaggcaag tgcaggggag tgcggcggat ggtggtgaag atggcaaaga
     2101 tccctgtgtc actagggcgg aggaacaaga ccacgtacaa agtttcatcc ttgagcagca
     2161 gtctgagtgt ggagggcaag gagctgggcc tgagggtgtc gtcggagccc accccattgc
     2221 tgaagatgaa aaacaatggc cggaatgtgg tggtggtctt cccgccaggt gagatgccta
     2281 ttattctcaa gcgaaagcgt ggccgccctc ctaagaacct gctgctgggt cctggcaaac
     2341 ccaaagagcc aacagtggta gctgccgagg ctgccgctgt gacagcggcc accatggcca
     2401 tgccggaggt gaagaaacgg cggcggagga aacaaaagct ggcatccccg cagccgtcct
     2461 acgcagcaga cgccaatgac agtaaggctg agtattccga tgtccttgcc aagctggcct
     2521 ttttgaaccg ccagagccag tgtgctggga gatgctcgcc accccgatgc tggacaccca
     2581 gtgagcctga gtcagtgcac caagccccgg acactcagag catctctcaa ttcctgcacc
     2641 gggtgcaggg cttccggagg cgtggaggca agacaggagg ctttggaggt aggggcggag
     2701 gccatgcagc caaggcagcc cgctgttcct ttagtgactt ttttgagggc attggcaaga
     2761 aaaagaaggt ggtagcagtg gcagctactg gggttgtggg tcctggtctc actgagctgg
     2821 ggcatccacg caaaaggggc cgaggcgagg tagatgctgt aactgggaaa cccaagcgca
     2881 agaggcggtc ccggaagaat gggactctgt tcccagagca ggtgcccagt ggcccaggct
     2941 ttggggaggc cggtgctgag tgggctgggg acaagggtgg tggctgggcc cctcaccatg
     3001 ggcacccagg agggcaagct ggccgaaact gtggtttcca ggggacggag gccagggctt
     3061 ttgcctccac tgggctggag agtggggctt caggccgtgg cagctactat gctggtgcac
     3121 cctcaggcca gacggagctc agccaggaac gccaaaacct cttcactggc tattttcggt
     3181 ccctgcttga ttcagatgac tcctctgacc tcttggactt tgccctatcg gcctctcgcc
     3241 cagagtcccg gaaggcatcg ggcaactatg cagggcctcc ctccagtgcg ctgcctgctc
     3301 agcgggggct tgccaccttc ccaagccggg gagccaaggg tagcccagtg gcagtgggca
     3361 acagtggagc tgggacagac ccctccttcc agcctgtcct gccttcccgt cagacctttc
     3421 caccaggccg ggcaacaagc tatgggataa ccccagccac ttcagactgc cgagcagctg
     3481 agaccttccc aaagctggct ccccctcctt cagctgtggc ccgctcgcct acaacccacc
     3541 ctcctgccaa cacctaccca cctcagtatg gtggctatgg ggcaggacaa agtgtgtttg
     3601 ccccagcaaa gcccttttca ggccaggact gtgctaatag taaggactgc agctttgcct
     3661 atggcagcgg caatagcctt cctgcctcac ccagcagcgc ccacagtgct ggctatgccc
     3721 cgccgcctac tgggggtccc tgtctaccgc ccagcaaggc ctccttcttc aacagctctg
     3781 aggggggccc cttctctggg tcagctccca cacccttgcg ctgtgacagt cgagccagta
     3841 ctgtctcacc cggtggctac atggtaccca agggcaccac agcttctgct gcctctgcgg
     3901 cctcctcctc ttcctcttcc tttcagccct cacctgagaa ctgtcggcag tttgtggggg
     3961 cttctcagtg gcctttccgg caggggtatg gaggcctgga ctgggcctcg gaggccttta
     4021 gtcagctcta caatcccaac tttgactgcc acgtcagtga acccaatgtg atcttggaca
     4081 tctcgaacta cacgccacag aaggtgaagc agcagactgc tgtgtccgag accttctccg
     4141 agtcatcctc tgacagcacc cagttcaatc agccagttgg tggtggtttt aggcgtgcca
     4201 acagtgaggc ctcaagcagt gagggccagt caagcctgtc cagcctggag aagctcatga
     4261 tggactggaa tgaagcatca tctgctcccg gctacaactg gaaccagagc gtcctctttc
     4321 agagtagctc aaagcctggc cgtggccggc ggaagaaggt ggacctgttt gaggcctcac
     4381 atttgggctt ttcaacatcc acctcagcca ctgcctctgg gtatccgtcc aaacggagca
     4441 ccggaccccg gcagcctcgg ggtggccggg gtagtggggc ctgctcagcc aagaaggaga
     4501 gaggtggtac agcggccaaa gccaagttca tccccaagcc acaaccagtg aatccactgt
     4561 tccaggacag cccagacctt ggcctggact actatagtgg ggacagcagc atgtcaccac
     4621 tgccctccca gtcgagagcc tttggtgtgg gagaacgaga tccctgtgac ttcatgggac
     4681 cttactccat gaatccatcc acaccttctg atggcacttt tggccaaggc ttccactgtg
     4741 actctcccag cctgggtgct cctgaccttg acagcaagca tttcccacca ctggcccacc
     4801 cacccacagt gtttgatgct ggcctgcaga aggcctactc acccacctgt tcaccgacac
     4861 taggcttcaa ggaagagttg cggccaccac cttcaaagct gactgcctgt gagcccctca
     4921 agcatggtct tcagggggct agcctgagtc atgcagccca ggcccacctg agctgccggg
     4981 acctaccgct aggccagcct cactatgagt cccctagttg caagggtaca gcctattggt
     5041 acccaccagg ttcagctgcc cgcagcccac cttatgaagg caaggtgggt tcagggctgc
     5101 tggctgactt cctgggcagg acggaggctg tctgcctcag tgcccctcac ctggctagcc
     5161 caccagccac gcccaaggcc gacaaggagc cattggagat gacccggccc ccaggtccac
     5221 cccgtggccc tgctgcagcc actgctggct atggctgccc actccttagt gacttaactc
     5281 tgtcccctgt gccgagggac tcgctgctgc ccctgcagga cactgcctac aggtatccag
     5341 gctttatgcc gcagacacac cctggcctgg gtgggggtcc taagagtggc ttcctggggc
     5401 ccatggcgga acctcaccct gaggacacat ttaccgtcac ctccctgtag taccaactga
     5461 agtgccgact ggaccacgag gttttgttcc tggctttcag aagaccaatg ccaagacccc
     5521 tcccagcgtc cacagcatcc tctggcagga gcgcctgccc ctctgcctcc cacctgcccc
     5581 ttgcacccct tgcagcccca tatcccaccc atgacccctc cttgcccatc tcctccacgc
     5641 agaagccgaa ggtgagccct ttctgcacaa aaccagcaat tgtaaatact ttttaaaatg
     5701 tacaaaactt aaaaacaaaa cacagtttta gaaaaagaca aaaaaaaaaa agagagagag
     5761 agcgagagcg agagagagag cgtgtgcaag aggttgtgag tggggcttcg aggtgtccag
     5821 agcccctgca agtgtgcact gagaaattta tctacaggtc gtttgacaaa aatgaacaat
     5881 atcctattta ttgtatatac tgttttatta taaattgtgg attgtatatt gcattctgta
     5941 aacctgctgt ggtcccgtgg tgtgcaaatt cgcatggtgg ggggggaggg agaacctctt
     6001 ttgggggctt tttttttttt tttctttttt ttttttttcc tttttcactc ttgggttttc
     6061 tcttctgttg ctgttgttgt tttttgttgg caggacacac ccaaagatcc aagtttgtat
     6121 taaaaagaaa tgaagaaaag caaaaaaaaa aaaaaaaaaa aaaaaaaacc aacttgtgtc
     6181 tgtaaaacag ggtacatgag ggtgggtggg actgtactgg tgatgtcagc ctctggtcct
     6241 tctgggagtt gaagtacctc aggatgttcc tggtttccct acctctgagt cctctcatct
     6301 gcctagtgtc tcggtgtcat ctccgtcccc caccagactc cgagtgtttt gcccacatgt
     6361 atgtttgtgc acagcatgtg tgagttggtg cccttgaagg tcagaaaagg gcatggaatc
     6421 cccgttacag acagctataa gctgtcattc cgatgctggg actcaaatcc atgtcctatg
     6481 caagaacagt gagtgttctc aacatcagaa acattgcgtt gactcgtccc cgctcctgtc
     6541 ctacatcccg tggctcccac agatgctttc ttttgcctga agagtcccat ggtaagtttg
     6601 gtcaccatct tcttcctctc gatgccctca gtccacctca ggtcccagag caccaccccg
     6661 acgtctgttt gtcctgtctc cctgaccatt aaggctccag acttctatca tggtcctaag
     6721 aggccgatct tcattttact gaggcagagt gtctctgtgt ggccccagct atcctagaac
     6781 ttgtatgtag tatgtaaacc aggctgacca gactcagacc tgcctgcctc atcttccgag
     6841 aactgggatt acacatgtgc cactgcaccc agcaa
//
LOCUS       NM_001437138             619 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 1, mRNA.
ACCESSION   NM_001437138 XM_039084501
VERSION     NM_001437138.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039084501.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2483652.1,
                                           SRR26643293.49057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000009.1  21074406-21074500
            96-619              JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..619
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..95
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="upstream in-frame stop codon"
     CDS             87..446
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Guca1a neighbor"
                     /codon_start=1
                     /product="putative uncharacterized protein CIMIP3 isoform
                     1"
                     /protein_id="NP_001424067.1"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
                     /translation="MLKESQKSLIPGHRQKTTSGRKGKKVPPPTPTPLSQKWKRDRKQ
                     SLESAYVPVVVDPRGQEPDSSFRFNFYNSQYSNSLNPFYTLQKPTCGYLYQRETDHTR
                     KCFGIPPANLVLWRSTY"
     exon            96..619
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccctcc cgagactccc cagatgcctc tggatcccta accaccagaa gttccatttt
       61 accatcaaag aggaaactga ccaaagatgt tgaaagagtc acagaaatcc ttaatccccg
      121 gtcaccggca aaagacgaca tcaggcagaa aggggaagaa ggtgccgccg cccacaccaa
      181 caccattgtc acagaaatgg aaacgggacc gcaaacagtc tctggagtca gcttatgtcc
      241 ccgtggtggt ggatcctcgc gggcaggagc cagacagtag tttcaggttc aatttctaca
      301 actcacagta ttccaactct ctcaatccct tctacaccct gcagaaaccc acctgtggtt
      361 acctgtacca gagagaaact gaccacacac ggaaatgctt tggcattcct cccgcaaacc
      421 tggtcttgtg gcgcagcacc tactaaatcc aaggcatctg gaagtcccca ccctgcacct
      481 tcactctgtg gtcctgggtc ccagagggaa aagtcattca ttcctggaga agcggcgtat
      541 acctgggcta gccaggtatg ctgtgacagc tgagggaggc ctcttcccaa taaacttcag
      601 tccttctttt tttctggca
//
LOCUS       NM_001437118            5284 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus RCAN family member 3 (Rcan3), transcript variant
            2, mRNA.
ACCESSION   NM_001437118 XM_039110405
VERSION     NM_001437118.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5284)
  AUTHORS   Guasch,A., Aranguren-Ibanez,A., Perez-Luque,R., Aparicio,D.,
            Martinez-Hoyer,S., Mulero,M.C., Serrano-Candelas,E., Perez-Riba,M.
            and Fita,I.
  TITLE     Calcineurin Undergoes a Conformational Switch Evoked via
            Peptidyl-Prolyl Isomerization
  JOURNAL   PLoS One 10 (8), e0134569 (2015)
   PUBMED   26248042
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5284)
  AUTHORS   Canaider,S., Facchin,F., Griffoni,C., Casadei,R., Vitale,L.,
            Lenzi,L., Frabetti,F., D'Addabbo,P., Carinci,P., Zannotti,M. and
            Strippoli,P.
  TITLE     Proteins encoded by human Down syndrome critical region gene 1-like
            2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with
            cardiac troponin I (TNNI3)
  JOURNAL   Gene 372, 128-136 (2006)
   PUBMED   16516408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039110405.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.16610.1,
                                           SRR26643296.16395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000005.1  152955258-152955485 c
            229-370             JAXUCZ010000005.1  152954727-152954868 c
            371-606             JAXUCZ010000005.1  152946794-152947029 c
            607-780             JAXUCZ010000005.1  152942483-152942656 c
            781-952             JAXUCZ010000005.1  152940256-152940427 c
            953-5284            JAXUCZ010000005.1  152934561-152938892 c
FEATURES             Location/Qualifiers
     source          1..5284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5284
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="RCAN family member 3"
                     /db_xref="GeneID:362627"
                     /db_xref="RGD:1311826"
     exon            1..228
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..370
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..606
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1131
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="regulator of calcineurin 3; Down syndrome critical
                     region gene 1-like 2"
                     /codon_start=1
                     /product="calcipressin-3"
                     /protein_id="NP_001424047.1"
                     /db_xref="GeneID:362627"
                     /db_xref="RGD:1311826"
                     /translation="MLRDSLKSWNDSQSDLCSSDQEEEEEMVFGENEDDLEEMMDLSD
                     LPTSLFACSVHEAVFEVQEQKERFEALFTLYDDQVTFQLFKSFRRVRINFSKPEAAAR
                     ARIELHESEFHGRKLKLYFAQVQVSGEARDKSYLLPPQPTKQFLISPPASPPVGWKQS
                     EDATPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEDTKNPKQKI
                     TQTRRPEAPTAALSERLDCAL"
     misc_feature    583..1086
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="Region: Calcipressin; pfam04847"
                     /db_xref="CDD:282674"
     misc_feature    583..1086
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="Region: Calcipressin; pfam04847"
                     /db_xref="CDD:282674"
     exon            607..780
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..952
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..5284
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgcacc cgttgggcgc gaggaaccca gggagggcgc gaggcgcgcg ggtccgggaa
       61 cgcgcgcgac gccggcgacc tcactcggcc ccaggtcacc gcccgtgtag ccggctgagg
      121 tggccgctgg ggcccgcgtc gagggcgtgg tggctcccgg cggtgaaagt ctgtccgccc
      181 ctggccgtgc tcgtttcccc cccggggcct ctcccctgga gcgcacagga tgcaggaatt
      241 gtcgctcttc tctgcttccc aggcttctgg aaacttgtgg tccgcctcct cctgaagcat
      301 cgcgccttca atagctgttt ccaggctgcc gggttccagc ttccgtgcga aatctcatca
      361 tctcctctgg cactgtctgg ccagcgtcct agaactttac cgacagagaa gatgcttcga
      421 gacagcctga aatcttggaa tgacagccag tcagacctct gtagcagcga ccaggaagag
      481 gaagaggaga tggtcttcgg tgaaaatgaa gacgatttgg aagagatgat ggacctcagc
      541 gacctgccca cctccctctt tgcttgcagt gtccacgaag cggtgtttga ggtccaagag
      601 cagaaggaga ggttcgaagc cctgttcacc ctctatgatg accaggtcac attccagctg
      661 ttcaagagct ttcgcagagt gaggatcaac ttcagcaagc ctgaggctgc ggcgagagca
      721 cggatcgagc tccatgagag tgaattccat ggccggaagc tgaagcttta cttcgcacag
      781 gtgcaggtgt ccggggaggc tcgggacaag tcctacttac tgccaccaca gcccaccaag
      841 cagttcctca tctcccctcc cgcctcaccc cccgtggggt ggaagcagag tgaagatgcc
      901 acgccagtga tcaactatga cctcctctgt gccgtctcca agctggggcc aggggagaaa
      961 tacgaactgc acgcaggaac cgagtccacc cccagtgtgg tggtgcacgt ctgtgagagc
     1021 gaaaccgaag aggaagaaga cacaaaaaat ccaaaacaga aaatcacgca gacgcggcgc
     1081 ccggaagctc ccacggcagc actgagtgag cggctggact gtgcactgtg agcggctgct
     1141 gcgcctgcgc cttccactgc tacagccgcg cctgccttgg agcgcagccc agcgatgctg
     1201 atgcatccgt ccagctgctg ggccagcctc cccgggccgg aacgtggaat gaagtggcag
     1261 attcagccag ccggttcaga tttcgaacag tattctaaat ggcactttaa gtgacaaggt
     1321 tagccctgac cgtgaggcac ctgtctcctc ccccagaaat attagttccc ttgaacctgt
     1381 agagcattgg gtaccggagg ccagagccag cgtcacccag tgcactgcca tttctacaga
     1441 cttaaacgtt agtctcactt cggtgtgggt atttttgtac aggtgtggcg gtgtctaaca
     1501 gattgagcaa aggctgaatg taattattca gtagacatga cctttctttt tgcacgagaa
     1561 gaaacctgag atacaaaatc atttgtagaa gtcatttttt ttttcaagta ttttttcact
     1621 agctttaggg atgaaaggcc aagtgactga gattgtcagg tccagatggc gtgggcagat
     1681 gcgcccttgg ctctcctggc tgtccatctt acttggcagt cagtgaaagt ggcgtgcaga
     1741 accctgctcc cagcgcagcc ctccccagcc tcagctctct gcaggagcct tgcctttgcc
     1801 agcagcctgt gtcccgggaa gcctggctga tggctttatg gagctggagc cccgggcagc
     1861 tcttccgtta ctctcttgac cctcctagtg ctggctgcta ctgcctgagg ttccctatgc
     1921 tgtgtgcgtc ggcacggatg taggtcgctc ttaacttcag acgataatga tgactgtgca
     1981 gaccaattta aattggggga gcaggttcgt ttttgttttc tttgaagaca gggtttcact
     2041 tggtagctcc cgggcctcaa atcctctgtg ttcctcctgc ctcagcttcc caagtgctgg
     2101 acttacaggg gagcaccatg tacttgaaag ttctccgttc aagtatttta gctgtttgga
     2161 aagaaaaatc acctgcactt ttcccctgca gattagggag aggagtcatt cttttggggg
     2221 tggttgagct tttttctttg tttgtttttg ttgttttgag acaaggtttc acactgtagc
     2281 tcaggctagc ctgtgactca ttatgtagcc caagctggcc ttgagcccaa gaccattctc
     2341 tttccttagc ctcctgagtg ttgggattgc aggcatgggc atgcagttca tgctttcctt
     2401 tttagtgaac atttccacct tcacttgcag ttggtgtcca gatagaattg cttcttactc
     2461 tttttttgtt tttttgtttt gttttgtttt gttttgtttt gttttgtttt gtttttccgg
     2521 agctggggac caaacccagg gccttgcgct cgctaggcaa gcgctctacc gctgagctaa
     2581 atccccagcc ctgcttctta ctcttggcgt gttgttccgt gggtcactct gcatctctgg
     2641 tgtgctgagc tgcagtccct tgctgaaggc tggctctcct gcctcggggt gctgtgttac
     2701 agacgctcga gtggctccac tcatccgact gttctgtcgc acaagcgttc agaactggca
     2761 ggaagatgtg aaggggcaca gaacagaaag tagcatagct gctactgcaa aggaaggagc
     2821 ttagagaagt gacgccatga gagccgtcat gggtgacatg tcagggctga gtcccttttg
     2881 tggtagaact gatttcatga gcgcacacac agaaacacac acacacacac acacacacac
     2941 acacagagag acacacacac acacacacac ctgttttctg tcttattaaa acagggtctc
     3001 acgtagtcca ggttgatctc aaacttgctg tgtcccaagg atgactttga actcctggtc
     3061 ctcctgcctc tgtctcctaa gtgctgggac tggaggtgtg tgccaccatc cctatcaaca
     3121 acagaagagt gtcccttgcc ttcagacact gtcagatgct gaagtctgca tttgccattg
     3181 ggaagcctcg gtgcagattc agttgaagat aaccattcca tccacacaag tcatctgcca
     3241 ggtaaaggga ttatatgcat atattttgtt ttgaggtgat gtctcacagt gtggcccagg
     3301 ttggtctcaa actccaggcc tgtgggtctt ccaacttgac tggatccagg cacacgccct
     3361 tgtcatcctg ggactttaga gttggatgca gtagatcagg aattcaaggc catccttggc
     3421 tacactgtgc ttggccctgc caagctcagc agtttgctac ttctggttgt aggatagacc
     3481 ctagctgtca gcaagcatgt tttcaactgg ggaggttttg tgttcctcat tatacagtac
     3541 atgctctgat tttctaagtg atcataaccc agtttttaaa tttgtcttgg ctttcatttt
     3601 ctacccacca attaaagaac atctattgct cttttttaag tcgagacact caaatctgtg
     3661 tgcatcctgt taccttggtc accagcagtt gtgtcagcac cttacgtggg gttccctgga
     3721 tactcacatt catggaatta aaatgtaaac agtggtaacg gggacccagg ctcaaagaat
     3781 gcatggagtt aaaggtttgc tgtgggatgt ccctctccct ctgcttagaa aatcaggttc
     3841 tattcaagac tcgtggtggg cctgggctat atattttatg taaactattt ttagactgga
     3901 ggatttagtt ttaagaggaa agctttgagc gcaattaaac catggaggtg taccagattc
     3961 ttcgatgcct tggggtcact cctgcttgct tgccttctat aaagcctcag acctcacctg
     4021 caaggtgaac ttggtcaccc tccacttccc tctgtgttcc ctaatgcatc tgtcttaaag
     4081 ggaacattgt ctgggtgtgg tgtaatctca gcctgcagga ggctgaggca ggaggattgc
     4141 ctgggataca tgagtaaccc ctctctcaga ataaggtatg ttccttttct cgctgtgaca
     4201 gttcagagga acagtcctgg agaaatgttt gcttctagcc aagaatcctg cgttctagag
     4261 actcattctg cacaaaacta agtacatgga ccaagtaaga tgtatgaacc ttgagcagcc
     4321 acgtgacaag tgactactgc tgtttcaaac tcccctcgtt gtgttctcca gggccatctt
     4381 cctcctcaag agtgccactg tctccctcag tcttgggcag agcacaattc atagtcagga
     4441 ttaccaaatg tattcagcgc ggtggcatat cccgtcatct cagcgcttgg gaggcagagg
     4501 tatgaggact ttgcaagttt aaggccagcc tgggccatgt accacgaccc tgtctcatca
     4561 acgagggggc tcctggatgt ccaggtgccc cagacagata gcagtgaccg tgcatctctg
     4621 gctgtggctg gggacttatc ttcctggtag cttctagtca aggctagaag tgatctcaga
     4681 taagtcagca tgcagacacc actaactggc ttcatgttct cctggaaacc tgcagttctt
     4741 gaagtgagtc ctgagacctg gcaggtcctg cgtggcctgg actggatgtg cgttcttgac
     4801 atgaggaggg tttcttatct atctatgcag ataacgcgtg gttttctgta ctgttccttt
     4861 ttgatctcca ctcttccaaa gtcagactga ggacaaaggg gggacagcag gtgtcagtcc
     4921 cgcgccgtgc cctctgctgt cagcccgagt atttattatg tcactgtgtt actgcacatt
     4981 gatttcatta ctgaaccgca gctggattta gtctcgaatc cggcctgtcc gcggcccccc
     5041 tggtcctgtg cactgtagtg aatccttgct gcacttgcag aaactggtca gtgagctttg
     5101 tccctgtgtc ccgtgatctt agtgtgcttg acgtgatggg ccatagttca ttatcagctt
     5161 caactctcct gtgtcctcag gatttctaac attcctcgtc ctgtaaggag gtaacaaagg
     5221 cagacatgtg attacctgta acagattttg atgttgaact aataaaaact tgttttgtaa
     5281 gtca
//
LOCUS       NM_001437158            3856 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 5, mRNA.
ACCESSION   NM_001437158 XM_006239251
VERSION     NM_001437158.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3856)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3856)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3856)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006239251.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212004.1, SRR22582424.1103289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-706             JAXUCZ010000005.1  158582911-158582987
            707-784             JAXUCZ010000005.1  158583894-158583971
            785-854             JAXUCZ010000005.1  158584121-158584190
            855-989             JAXUCZ010000005.1  158584860-158584994
            990-1056            JAXUCZ010000005.1  158585080-158585146
            1057-1188           JAXUCZ010000005.1  158585223-158585354
            1189-1344           JAXUCZ010000005.1  158587265-158587420
            1345-1455           JAXUCZ010000005.1  158588430-158588540
            1456-1502           JAXUCZ010000005.1  158588624-158588670
            1503-1691           JAXUCZ010000005.1  158588750-158588938
            1692-1898           JAXUCZ010000005.1  158589800-158590006
            1899-1988           JAXUCZ010000005.1  158590386-158590475
            1989-2148           JAXUCZ010000005.1  158590555-158590714
            2149-2269           JAXUCZ010000005.1  158590833-158590953
            2270-2394           JAXUCZ010000005.1  158591073-158591197
            2395-2555           JAXUCZ010000005.1  158591857-158592017
            2556-2672           JAXUCZ010000005.1  158592132-158592248
            2673-2752           JAXUCZ010000005.1  158592331-158592410
            2753-2905           JAXUCZ010000005.1  158592944-158593096
            2906-3002           JAXUCZ010000005.1  158593200-158593296
            3003-3226           JAXUCZ010000005.1  158593909-158594132
            3227-3378           JAXUCZ010000005.1  158594217-158594368
            3379-3474           JAXUCZ010000005.1  158594595-158594690
            3475-3856           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3856
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3524
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 5 is encoded by transcript variant 5;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 5"
                     /protein_id="NP_001424087.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAQVLRYY
                     ILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGIP
                     VKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQS
                     MTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECVV
                     NESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTRT
                     GFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVKE
                     IVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDK
                     TGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGDP
                     MDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFSS
                     ALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVAL
                     AGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVM
                     VTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDP
                     VQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLVC
                     ELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIRE
                     GRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSR
                     TGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPA
                     PDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGATRTEEHCGQLFQVAAA
                     GSGRLQLCGRLHAGERAGPVSPSLPAVAAA"
     misc_feature    282..3377
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3377
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..706
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            707..784
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            785..854
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            855..989
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1056
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1188
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1344
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1502
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1691
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1898
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1988
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2148
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2269
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2394
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2555
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2672
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2752
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2905
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3002
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3226
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3378
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3474
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3856
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcac aggtactgcg ctattacatc ctccagggcc
      661 aacgctatgt ctggatggag acccagcaag ccttctgcca agtcagcctg ctggaccacg
      721 gtcgtgcctg cgatgacatc cattgctcca gttctggcct cagcctccag gaccaggctg
      781 tgaggaagac catttacggc cccaacgtga ttggtattcc cgtcaagtcc tacctgcagc
      841 tactggtgga tgaggcactg aacccctact acggattcca ggccttcagc atcgccctgt
      901 ggctggctga ccactactac tggtatgctg tctgcatctt cctcatctcg gccatctcca
      961 tctgcctgtc tctctacaag accaggaagc aaagcatgac tctgagggac atggtcaagt
     1021 tgtccgtgcg ggtgcaggtg tgccgacccg gaggagagga agagtgggtg gactccagtg
     1081 agctggtgcc cggagactgc ctggtactgc cccaggaggg cggaatgatg ccgtgtgatg
     1141 ctgctctggt ggccggggag tgtgtggtca atgagagctc cctgacagga gaaagcatcc
     1201 cagtgttgaa gacagccctg ccagaggggc cccagcccta ctgcccagag acccaccggc
     1261 ggcacactct cttctgtggc accctcgttc tgcaggcccg ggcctacctg ggaccccgtg
     1321 tcctagccgt ggtaactcgg acagggttct gcacagccaa agggggcctg gtgagctcca
     1381 tcctacaccc acggcccatc agcttcaagt tctacagaca cagcatgaag tttgtggcag
     1441 cgctgtccgt cctggctctg ctcggtacca tctacagcat catcattctc taccgaaacc
     1501 gggtgcccgt gaaggagatc gtgatccgag ctctggacct ggtgacggtg gtggtaccac
     1561 ccgccctgcc ggccgccatg accgtgtgca cactctacgc ccagagccgg ctgcgtacac
     1621 agggcatctt ctgtatccac ccgctgcgca tcaacttggg gggcaagctg cgcctcgtgt
     1681 gcttcgacaa gacaggcacc ctcacggagg acggattgga cataatgggg gtggtgcccc
     1741 taaaggggca gatgttgctg ccactggtcc cagagccctg ccacctgccc ccagggcccc
     1801 tcctccgagc actggtcacc tgtcatgccc tcagccagct acatgatacc ttggtgggcg
     1861 accccatgga tctcaagatg gtggagtcta caggctgggt cttagaggag ggttcggctg
     1921 caggctcagc acctgagacc caggtcttgg tggtaatgcg acccccaccc agggggcctc
     1981 agcaacagga agagtcacca gagccagtca gtgtcctccg ccgcttcccc ttctcctctg
     2041 ccctgcagcg gatggacgtg gtggtgacat ggccaggggc cacccagcct gaggcctacg
     2101 tcaaaggttc cccagagctt gtggccagcc tctgcagccc cgagacagtg cccagagact
     2161 ttcctcaggt actgcagagc tacacagctg ctggctaccg agttgtggcc ctggctggca
     2221 agccactgcc cactgcgccc agccttgagg ccgctcagca gctgacaagg gacactgtgg
     2281 agcaggagct gagcctcctg gggctgctgg tcatgcggaa cctgctgaag ccacagacga
     2341 ccccagttat acagaccctg aggaagacgg gcatccgtac tgttatggtg acaggggaca
     2401 acctgcagac agcagtcacg gtggccaaag cgtgtggcat ggtgggcacc caggagcacc
     2461 tggctatcat ccatgccacc caccctgagc agggccagcc tgctgccctt gagttcctgc
     2521 caactgagcc ctctgcggcc atgaatgggg caaaggatcc tgtgcaggcc acggactacc
     2581 ccgtggagcc ggagtcccag tcccgtcacc tggccctcag tgggtccacg tttgctgtcc
     2641 ttcagaagca cttccccaag ctgctgccca aggtcctggt gcaggccacc gtctttgccc
     2701 gcatggcccc ggagcagaag acacagctag tgtgtgaact tcagagactt cagtactgcg
     2761 tgggcatgtg cggggatgga gccaatgact gtggggccct gaaggcggct gacgtgggca
     2821 tctcactgtc ccaggcagag gcctcagtgg tctctccgtt cacctccagc atggccagta
     2881 ttgaatgtgt gcccactgtc atcagggaag gccgctgctc tctggacact tcattcagcg
     2941 tcttcaagta tatggcccta tacagcctga cccagttcat ctctgtcctc attctctaca
     3001 caatcaacac caacctggga gacctacagt tcttggccat cgacctgttc atcaccacca
     3061 cggttgccgt gctcatgagc cgcaccggcc ctgcactgac cttggtgcga gcacggccac
     3121 caggggcgct gctgagcgtg cctgtacttg gcagtttgct gctgcaggtg gccttggtgg
     3181 ccggcatcca gcttgggggc tactttttgg tcatagctca gccctggttt gtgcctctga
     3241 acagaactgt acccgcacct gacaacctgc ccaactacga gaacacagtg atcttctctc
     3301 tgtctggctt ccagtacctc atcctggccg cagcggtgtc taagggggca cccttccgcc
     3361 agccgctcta caccaacggg gccactagga ctgaggaaca ttgcggacag ctctttcaag
     3421 ttgctgctgc tgggtctggt cgccttcaac tttgtgggcg ccttcatgct ggagagcgtg
     3481 ctggaccagt gtctcccagc ctgcctgcag tggctgcggc ctaaacgggc ctccaagaag
     3541 caattcaagc agctacaacg ggagcttgct gaacgtccat ggcccactct gcccgttggc
     3601 tccgtgaggt agtgcaggcc ttggagggca tgctggacac tggatctccc tgcccctgag
     3661 ccatgaccgg aactctccct agagacagta ccagtcacct cccacagccc tgaggttggc
     3721 tgtcacactc ctggggacac actcgcctgg ggaggcgttg attgttgcct cactgtgtag
     3781 agacagcagc taccaactcc atccggagca gctgtcatgg agcaaataaa gtgccggctt
     3841 tcctgtcttg gcagca
//
LOCUS       NM_001437160            3726 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 7, mRNA.
ACCESSION   NM_001437160 XM_063288079
VERSION     NM_001437160.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_063288079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21615.1,
                                           SRR26643297.20924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1784           JAXUCZ010000005.1  158590386-158590475
            1785-1944           JAXUCZ010000005.1  158590555-158590714
            1945-2065           JAXUCZ010000005.1  158590833-158590953
            2066-2190           JAXUCZ010000005.1  158591073-158591197
            2191-2351           JAXUCZ010000005.1  158591857-158592017
            2352-2468           JAXUCZ010000005.1  158592132-158592248
            2469-2548           JAXUCZ010000005.1  158592331-158592410
            2549-2701           JAXUCZ010000005.1  158592944-158593096
            2702-2798           JAXUCZ010000005.1  158593200-158593296
            2799-3022           JAXUCZ010000005.1  158593909-158594132
            3023-3174           JAXUCZ010000005.1  158594217-158594368
            3175-3344           JAXUCZ010000005.1  158594521-158594690
            3345-3726           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3726
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3482
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 7 is encoded by transcript variant 7;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 7"
                     /protein_id="NP_001424089.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFSSALQRMDVVVT
                     WPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPS
                     LEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAV
                     TVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEP
                     ESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLVCELQRLQYCVG
                     MCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFS
                     VFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGPALTLVRA
                     RPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENT
                     VIFSLSGFQYLILAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGLILVPGLLQGPL
                     GLRNIADSSFKLLLLGLVAFNFVGAFMLESVLDQCLPACLQWLRPKRASKKQFKQLQR
                     ELAERPWPTLPVGSVR"
     misc_feature    282..3308
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3308
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1784
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1944
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2065
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2190
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2351
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2468
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2548
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2701
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2798
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3022
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3174
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3344
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3726
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caaggtctta gaggagggtt cggctgcagg ctcagcacct gagacccagg
     1741 tcttggtggt aatgcgaccc ccacccaggg ggcctcagca acaggaagag tcaccagagc
     1801 cagtcagtgt cctccgccgc ttccccttct cctctgccct gcagcggatg gacgtggtgg
     1861 tgacatggcc aggggccacc cagcctgagg cctacgtcaa aggttcccca gagcttgtgg
     1921 ccagcctctg cagccccgag acagtgccca gagactttcc tcaggtactg cagagctaca
     1981 cagctgctgg ctaccgagtt gtggccctgg ctggcaagcc actgcccact gcgcccagcc
     2041 ttgaggccgc tcagcagctg acaagggaca ctgtggagca ggagctgagc ctcctggggc
     2101 tgctggtcat gcggaacctg ctgaagccac agacgacccc agttatacag accctgagga
     2161 agacgggcat ccgtactgtt atggtgacag gggacaacct gcagacagca gtcacggtgg
     2221 ccaaagcgtg tggcatggtg ggcacccagg agcacctggc tatcatccat gccacccacc
     2281 ctgagcaggg ccagcctgct gcccttgagt tcctgccaac tgagccctct gcggccatga
     2341 atggggcaaa ggatcctgtg caggccacgg actaccccgt ggagccggag tcccagtccc
     2401 gtcacctggc cctcagtggg tccacgtttg ctgtccttca gaagcacttc cccaagctgc
     2461 tgcccaaggt cctggtgcag gccaccgtct ttgcccgcat ggccccggag cagaagacac
     2521 agctagtgtg tgaacttcag agacttcagt actgcgtggg catgtgcggg gatggagcca
     2581 atgactgtgg ggccctgaag gcggctgacg tgggcatctc actgtcccag gcagaggcct
     2641 cagtggtctc tccgttcacc tccagcatgg ccagtattga atgtgtgccc actgtcatca
     2701 gggaaggccg ctgctctctg gacacttcat tcagcgtctt caagtatatg gccctataca
     2761 gcctgaccca gttcatctct gtcctcattc tctacacaat caacaccaac ctgggagacc
     2821 tacagttctt ggccatcgac ctgttcatca ccaccacggt tgccgtgctc atgagccgca
     2881 ccggccctgc actgaccttg gtgcgagcac ggccaccagg ggcgctgctg agcgtgcctg
     2941 tacttggcag tttgctgctg caggtggcct tggtggccgg catccagctt gggggctact
     3001 ttttggtcat agctcagccc tggtttgtgc ctctgaacag aactgtaccc gcacctgaca
     3061 acctgcccaa ctacgagaac acagtgatct tctctctgtc tggcttccag tacctcatcc
     3121 tggccgcagc ggtgtctaag ggggcaccct tccgccagcc gctctacacc aacgtgccct
     3181 tcctggtggc cctggcgctc ttgggctctg tcctggtggg cctcatcctg gtccccggcc
     3241 tcctgcaggg gccactagga ctgaggaaca ttgcggacag ctctttcaag ttgctgctgc
     3301 tgggtctggt cgccttcaac tttgtgggcg ccttcatgct ggagagcgtg ctggaccagt
     3361 gtctcccagc ctgcctgcag tggctgcggc ctaaacgggc ctccaagaag caattcaagc
     3421 agctacaacg ggagcttgct gaacgtccat ggcccactct gcccgttggc tccgtgaggt
     3481 agtgcaggcc ttggagggca tgctggacac tggatctccc tgcccctgag ccatgaccgg
     3541 aactctccct agagacagta ccagtcacct cccacagccc tgaggttggc tgtcacactc
     3601 ctggggacac actcgcctgg ggaggcgttg attgttgcct cactgtgtag agacagcagc
     3661 taccaactcc atccggagca gctgtcatgg agcaaataaa gtgccggctt tcctgtcttg
     3721 gcagca
//
LOCUS       NM_001437140             859 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 3, mRNA.
ACCESSION   NM_001437140 XM_039084495
VERSION     NM_001437140.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039084495.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2683837.1,
                                           SRR26360181.3292085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000009.1  21079157-21079391
            236-335             JAXUCZ010000009.1  21079517-21079616
            336-859             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..859
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..235
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            236..335
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    240..242
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="upstream in-frame stop codon"
     CDS             252..686
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="isoform 2 is encoded by transcript variant 3;
                     Guca1a neighbor"
                     /codon_start=1
                     /product="putative uncharacterized protein CIMIP3 isoform
                     2"
                     /protein_id="NP_001424069.1"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
                     /translation="MDHAVVTTKSGLWSERKRRELEGRVTPKESQKSLIPGHRQKTTS
                     GRKGKKVPPPTPTPLSQKWKRDRKQSLESAYVPVVVDPRGQEPDSSFRFNFYNSQYSN
                     SLNPFYTLQKPTCGYLYQRETDHTRKCFGIPPANLVLWRSTY"
     exon            336..859
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctctact agaattcagc tgaggtgaac ctacatttcc tgagctctca cttctgaatg
       61 tgtcaaggcc ctcgaggttt ggagtaaaga aacaggattt agggagcttc tatgtcgcga
      121 gtaaggggcc ttcctagaga tgggaagcaa gggagtcgct tctgccctgc gctgattgga
      181 ttcttgaatg atttgaaggt gaccaaaaga aaggctagag ggaccggaag cagaaataat
      241 agacacaaaa gatggatcac gcggttgtca ctaccaaaag tggactttgg agcgaacgga
      301 aaaggcgaga gcttgaaggg agagtgactc cgaaggagtc acagaaatcc ttaatccccg
      361 gtcaccggca aaagacgaca tcaggcagaa aggggaagaa ggtgccgccg cccacaccaa
      421 caccattgtc acagaaatgg aaacgggacc gcaaacagtc tctggagtca gcttatgtcc
      481 ccgtggtggt ggatcctcgc gggcaggagc cagacagtag tttcaggttc aatttctaca
      541 actcacagta ttccaactct ctcaatccct tctacaccct gcagaaaccc acctgtggtt
      601 acctgtacca gagagaaact gaccacacac ggaaatgctt tggcattcct cccgcaaacc
      661 tggtcttgtg gcgcagcacc tactaaatcc aaggcatctg gaagtcccca ccctgcacct
      721 tcactctgtg gtcctgggtc ccagagggaa aagtcattca ttcctggaga agcggcgtat
      781 acctgggcta gccaggtatg ctgtgacagc tgagggaggc ctcttcccaa taaacttcag
      841 tccttctttt tttctggca
//
LOCUS       NM_021703               1698 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus A-kinase anchoring protein 14 (Akap14), mRNA.
ACCESSION   NM_021703
VERSION     NM_021703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Carnegie,G.K., Means,C.K. and Scott,J.D.
  TITLE     A-kinase anchoring proteins: from protein complexes to physiology
            and disease
  JOURNAL   IUBMB Life 61 (4), 394-406 (2009)
   PUBMED   19319965
  REMARK    Review article
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Kultgen,P.L., Byrd,S.K., Ostrowski,L.E. and Milgram,S.L.
  TITLE     Characterization of an A-kinase anchoring protein in human ciliary
            axonemes
  JOURNAL   Mol Biol Cell 13 (12), 4156-4166 (2002)
   PUBMED   12475942
REFERENCE   4  (bases 1 to 1698)
  AUTHORS   Mei,X., Singh,I.S., Erlichman,J. and Orr,G.A.
  TITLE     Cloning and characterization of a testis-specific, developmentally
            regulated A-kinase-anchoring protein (TAKAP-80) present on the
            fibrous sheath of rat sperm
  JOURNAL   Eur J Biochem 246 (2), 425-432 (1997)
   PUBMED   9208934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 27, 2025 this sequence version replaced NM_021703.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ002474.1, SRR26360181.2918524.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000021.1  121276147-121276222 c
            77-1176             JAXUCZ010000021.1  121270835-121271934 c
            1177-1268           JAXUCZ010000021.1  121270652-121270743 c
            1269-1448           JAXUCZ010000021.1  121266286-121266465 c
            1449-1501           JAXUCZ010000021.1  121262143-121262195 c
            1502-1698           JAXUCZ010000021.1  121261195-121261391 c
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..1698
                     /gene="Akap14"
                     /note="A-kinase anchoring protein 14"
                     /db_xref="GeneID:60332"
                     /db_xref="RGD:708510"
     exon            1..76
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1176
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1595
                     /gene="Akap14"
                     /note="TAKAP-1.2; testis-specific A-kinase-anchoring
                     protein TAKAP-80; AKAP-14; Testis-specific
                     A-kinase-anchoring-protein; A kinase (PRKA) anchor protein
                     14"
                     /codon_start=1
                     /product="A-kinase anchor protein 14"
                     /protein_id="NP_067735.1"
                     /db_xref="GeneID:60332"
                     /db_xref="RGD:708510"
                     /translation="MNNKKKPPNQKAKTVENTSTAKAKKPEAPEPKNVTEPKDSKAVE
                     DPKKSVTNQKEKKTVTIIADPKDKKSVTEPKEKKTVTISDPKDKKPVIEKDKRTVTFV
                     TDVKDKRIVTDTKENRIASIDTKEKGPVVPEVKEKKVQLIDPKEKVVAPVAPVAPVAH
                     AAQVPHAAQVPHAVQVPHAVPVAHAAPVAHTAQVSHAAPVAPSLPVVPPAPVVPLAPV
                     VPPAPVAHTEPVAHAVPFAPPAPVAPPASVAPPVPDAPVALVAPVAPQVKQKIRVSEV
                     KRKKEVPPRVPQLKEMKVVLFTPEIKEKKVVSEIKEKTQVIDGKEKLIVPDVKEKKPA
                     VVEKKDERMNEIARTVVEGVLAASVQFVEEARNPIKNIKWLTHGEFTAEKGRKQIEKF
                     VSTWEFQNRWVYYADFIEKKDLIHSFHYIYRVRWSAPTAVRPMARVSANAYFTIKFNK
                     SKPADMPVDVSYIFENSELLQRPGKIRFREQWLRDITETKHILLESIPFKVV"
     misc_feature    87..338
                     /gene="Akap14"
                     /note="propagated from UniProtKB/Swiss-Prot (O35817.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    681..881
                     /gene="Akap14"
                     /note="propagated from UniProtKB/Swiss-Prot (O35817.1);
                     Region: 8 X 4 AA repeat of P-X-X-P"
     misc_feature    858..1220
                     /gene="Akap14"
                     /note="propagated from UniProtKB/Swiss-Prot (O35817.1);
                     Region: RII-binding"
     misc_feature    1206..1565
                     /gene="Akap14"
                     /note="28 kDa A-kinase anchor; Region: AKAP28; pfam14469"
                     /db_xref="CDD:464180"
     misc_feature    1206..1565
                     /gene="Akap14"
                     /note="28 kDa A-kinase anchor; Region: AKAP28; pfam14469"
                     /db_xref="CDD:464180"
     exon            1177..1268
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1448
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1501
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1698
                     /gene="Akap14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaccttg gggcagagcc gctgagagac tgctaaagct tcctctgcta ctccttcaaa
       61 gaacctgctc atttaggcaa aataaaatga ataacaaaaa aaagccccca aaccagaagg
      121 cgaagactgt ggagaacact agcacagcca aggcaaagaa accggaggct ccagagccca
      181 agaatgttac agaaccaaaa gatagtaagg ccgtggagga cccaaagaag tctgtgacaa
      241 atcagaaaga gaagaaaacg gtgaccatca ttgcagaccc aaaggacaaa aagagtgtga
      301 cggaaccaaa agaaaagaag actgtgacga tctcagatcc caaagacaag aaacctgtga
      361 tagagaaaga caagaggacg gtgacatttg tgacagacgt aaaagacaag aggattgtga
      421 ccgacacaaa agaaaacagg attgcatcaa tagacacaaa agaaaagggt ccagtagtgc
      481 cagaagtaaa agagaagaaa gtgcagctaa tagatccgaa agagaaggtg gttgcaccgg
      541 ttgcaccggt tgcgccggtt gcgcatgctg cccaggttcc tcatgctgcc caggttccgc
      601 atgctgtcca ggttccgcat gctgtgccgg ttgcgcatgc tgcgccggtt gcgcatactg
      661 cccaggtttc gcatgctgcg ccggttgcgc cttctctgcc tgttgtgcca cctgcgccgg
      721 ttgtgccact tgcgccagtt gtgccacctg cgccagttgc tcatactgaa ccggtagcac
      781 atgctgtgcc gtttgcgcca cctgcgccgg ttgcgccacc tgcgtcagtt gcgccacctg
      841 tgccagatgc tccagttgcg ctagttgcgc cagttgctcc acaagtaaaa cagaagattc
      901 gggtgtcgga ggtgaagcgg aaaaaggaag tgccaccacg tgtgccccag ttaaaggaaa
      961 tgaaggtggt gttattcaca ccagagataa aagaaaaaaa ggttgtgtct gagatcaaag
     1021 agaagacaca agtaatagat ggaaaagaga agttaattgt gccagacgta aaagagaaaa
     1081 agcctgcagt tgtagagaaa aaagacgaga ggatgaatga gatagctcgg actgtagttg
     1141 agggcgtact ggctgcttct gttcagtttg tggaagaagc cagaaatccc atcaagaaca
     1201 tcaagtggct cactcatggg gaattcacgg cagaaaaggg tcgaaaacaa attgaaaagt
     1261 ttgtttcaac atgggagttt caaaaccgct gggtgtacta tgcagatttt atagagaaga
     1321 aagacctaat tcactccttc cactatatct accgggtgcg ctggagtgcc cccactgctg
     1381 tgagacccat ggcacgagtc agtgccaacg cctacttcac catcaagttc aacaagagca
     1441 aacctgcgga tatgcctgtt gatgtctctt atatctttga gaattcagaa ctacttcaaa
     1501 ggccaggaaa gattcgattt cgagaacaat ggctgaggga cattactgag accaaacata
     1561 ttttgttgga gtctatccct tttaaagttg tctgattcct gtgttatgtt tgaggatgtt
     1621 ttacaaccga cattaaaaat atgaaacagc atatcaaatc acataatatt tattgaataa
     1681 taaactcatg gcacataa
//
LOCUS       NM_001173432            3849 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 3, mRNA.
ACCESSION   NM_001173432 XM_001072145 XM_342962
VERSION     NM_001173432.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3849)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3849)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3849)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3849)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3849)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3849)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3849)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3849)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3849)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3849)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced NM_001173432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1901           JAXUCZ010000005.1  158589800-158590006
            1902-1991           JAXUCZ010000005.1  158590386-158590475
            1992-2151           JAXUCZ010000005.1  158590555-158590714
            2152-2272           JAXUCZ010000005.1  158590833-158590953
            2273-2397           JAXUCZ010000005.1  158591073-158591197
            2398-2558           JAXUCZ010000005.1  158591857-158592017
            2559-2675           JAXUCZ010000005.1  158592132-158592248
            2676-2755           JAXUCZ010000005.1  158592331-158592410
            2756-2908           JAXUCZ010000005.1  158592944-158593096
            2909-3005           JAXUCZ010000005.1  158593200-158593296
            3006-3229           JAXUCZ010000005.1  158593909-158594132
            3230-3381           JAXUCZ010000005.1  158594217-158594368
            3382-3467           JAXUCZ010000005.1  158594605-158594690
            3468-3849           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3849
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3605
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 3 is encoded by transcript variant 3;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 3"
                     /protein_id="NP_001166903.2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLV
                     CELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR
                     EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMS
                     RTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVP
                     APDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGLRNIADSSFKLLLLGL
                     VAFNFVGAFMLESVLDQCLPACLQWLRPKRASKKQFKQLQRELAERPWPTLPVGSVR"
     misc_feature    282..3380
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3380
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1901
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2397
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2558
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2675
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2755
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2908
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3005
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3229
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3381
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3467
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3849
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caagacaggc accctcacgg aggacggatt ggacataatg ggggtggtgc
     1741 ccctaaaggg gcagatgttg ctgccactgg tcccagagcc ctgccacctg cccccagggc
     1801 ccctcctccg agcactggtc acctgtcatg ccctcagcca gctacatgat accttggtgg
     1861 gcgaccccat ggatctcaag atggtggagt ctacaggctg ggtcttagag gagggttcgg
     1921 ctgcaggctc agcacctgag acccaggtct tggtggtaat gcgaccccca cccagggggc
     1981 ctcagcaaca ggaagagtca ccagagccag tcagtgtcct ccgccgcttc cccttctcct
     2041 ctgccctgca gcggatggac gtggtggtga catggccagg ggccacccag cctgaggcct
     2101 acgtcaaagg ttccccagag cttgtggcca gcctctgcag ccccgagaca gtgcccagag
     2161 actttcctca ggtactgcag agctacacag ctgctggcta ccgagttgtg gccctggctg
     2221 gcaagccact gcccactgcg cccagccttg aggccgctca gcagctgaca agggacactg
     2281 tggagcagga gctgagcctc ctggggctgc tggtcatgcg gaacctgctg aagccacaga
     2341 cgaccccagt tatacagacc ctgaggaaga cgggcatccg tactgttatg gtgacagggg
     2401 acaacctgca gacagcagtc acggtggcca aagcgtgtgg catggtgggc acccaggagc
     2461 acctggctat catccatgcc acccaccctg agcagggcca gcctgctgcc cttgagttcc
     2521 tgccaactga gccctctgcg gccatgaatg gggcaaagga tcctgtgcag gccacggact
     2581 accccgtgga gccggagtcc cagtcccgtc acctggccct cagtgggtcc acgtttgctg
     2641 tccttcagaa gcacttcccc aagctgctgc ccaaggtcct ggtgcaggcc accgtctttg
     2701 cccgcatggc cccggagcag aagacacagc tagtgtgtga acttcagaga cttcagtact
     2761 gcgtgggcat gtgcggggat ggagccaatg actgtggggc cctgaaggcg gctgacgtgg
     2821 gcatctcact gtcccaggca gaggcctcag tggtctctcc gttcacctcc agcatggcca
     2881 gtattgaatg tgtgcccact gtcatcaggg aaggccgctg ctctctggac acttcattca
     2941 gcgtcttcaa gtatatggcc ctatacagcc tgacccagtt catctctgtc ctcattctct
     3001 acacaatcaa caccaacctg ggagacctac agttcttggc catcgacctg ttcatcacca
     3061 ccacggttgc cgtgctcatg agccgcaccg gccctgcact gaccttggtg cgagcacggc
     3121 caccaggggc gctgctgagc gtgcctgtac ttggcagttt gctgctgcag gtggccttgg
     3181 tggccggcat ccagcttggg ggctactttt tggtcatagc tcagccctgg tttgtgcctc
     3241 tgaacagaac tgtacccgca cctgacaacc tgcccaacta cgagaacaca gtgatcttct
     3301 ctctgtctgg cttccagtac ctcatcctgg ccgcagcggt gtctaagggg gcacccttcc
     3361 gccagccgct ctacaccaac ggactgagga acattgcgga cagctctttc aagttgctgc
     3421 tgctgggtct ggtcgccttc aactttgtgg gcgccttcat gctggagagc gtgctggacc
     3481 agtgtctccc agcctgcctg cagtggctgc ggcctaaacg ggcctccaag aagcaattca
     3541 agcagctaca acgggagctt gctgaacgtc catggcccac tctgcccgtt ggctccgtga
     3601 ggtagtgcag gccttggagg gcatgctgga cactggatct ccctgcccct gagccatgac
     3661 cggaactctc cctagagaca gtaccagtca cctcccacag ccctgaggtt ggctgtcaca
     3721 ctcctgggga cacactcgcc tggggaggcg ttgattgttg cctcactgtg tagagacagc
     3781 agctaccaac tccatccgga gcagctgtca tggagcaaat aaagtgccgg ctttcctgtc
     3841 ttggcagca
//
LOCUS       NM_001437142             791 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 5, mRNA.
ACCESSION   NM_001437142 XM_039084493
VERSION     NM_001437142.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039084493.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2070147.1,
                                           SRR26360181.2815694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JAXUCZ010000009.1  21079157-21079354
            199-267             JAXUCZ010000009.1  21079517-21079585
            268-791             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..791
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..198
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    100..102
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="upstream in-frame stop codon"
     CDS             112..618
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="isoform 4 is encoded by transcript variant 5;
                     Guca1a neighbor"
                     /codon_start=1
                     /product="putative uncharacterized protein CIMIP3 isoform
                     4"
                     /protein_id="NP_001424071.1"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
                     /translation="MSRVRGLPRDGKQGSRFCPALIGFLNDLKIIDTKDGSRGCHYQK
                     WTLERTEKESQKSLIPGHRQKTTSGRKGKKVPPPTPTPLSQKWKRDRKQSLESAYVPV
                     VVDPRGQEPDSSFRFNFYNSQYSNSLNPFYTLQKPTCGYLYQRETDHTRKCFGIPPAN
                     LVLWRSTY"
     exon            199..267
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            268..791
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctctact agaattcagc tgaggtgaac ctacatttcc tgagctctca cttctgaatg
       61 tgtcaaggcc ctcgaggttt ggagtaaaga aacaggattt agggagcttc tatgtcgcga
      121 gtaaggggcc ttcctagaga tgggaagcaa gggagtcgct tctgccctgc gctgattgga
      181 ttcttgaatg atttgaagat aatagacaca aaagatggat cacgcggttg tcactaccaa
      241 aagtggactt tggagcgaac ggaaaaggag tcacagaaat ccttaatccc cggtcaccgg
      301 caaaagacga catcaggcag aaaggggaag aaggtgccgc cgcccacacc aacaccattg
      361 tcacagaaat ggaaacggga ccgcaaacag tctctggagt cagcttatgt ccccgtggtg
      421 gtggatcctc gcgggcagga gccagacagt agtttcaggt tcaatttcta caactcacag
      481 tattccaact ctctcaatcc cttctacacc ctgcagaaac ccacctgtgg ttacctgtac
      541 cagagagaaa ctgaccacac acggaaatgc tttggcattc ctcccgcaaa cctggtcttg
      601 tggcgcagca cctactaaat ccaaggcatc tggaagtccc caccctgcac cttcactctg
      661 tggtcctggg tcccagaggg aaaagtcatt cattcctgga gaagcggcgt atacctgggc
      721 tagccaggta tgctgtgaca gctgagggag gcctcttccc aataaacttc agtccttctt
      781 tttttctggc a
//
LOCUS       NM_001437161            3652 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 8, mRNA.
ACCESSION   NM_001437161 XM_063288081
VERSION     NM_001437161.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3652)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3652)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3652)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3652)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3652)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3652)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_063288081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20922.1,
                                           SRR26643296.16593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1784           JAXUCZ010000005.1  158590386-158590475
            1785-1944           JAXUCZ010000005.1  158590555-158590714
            1945-2065           JAXUCZ010000005.1  158590833-158590953
            2066-2190           JAXUCZ010000005.1  158591073-158591197
            2191-2351           JAXUCZ010000005.1  158591857-158592017
            2352-2468           JAXUCZ010000005.1  158592132-158592248
            2469-2548           JAXUCZ010000005.1  158592331-158592410
            2549-2701           JAXUCZ010000005.1  158592944-158593096
            2702-2798           JAXUCZ010000005.1  158593200-158593296
            2799-3022           JAXUCZ010000005.1  158593909-158594132
            3023-3174           JAXUCZ010000005.1  158594217-158594368
            3175-3270           JAXUCZ010000005.1  158594595-158594690
            3271-3652           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3652
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3320
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 8 is encoded by transcript variant 8;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 8"
                     /protein_id="NP_001424090.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFSSALQRMDVVVT
                     WPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPS
                     LEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAV
                     TVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEP
                     ESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLVCELQRLQYCVG
                     MCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFS
                     VFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGPALTLVRA
                     RPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENT
                     VIFSLSGFQYLILAAAVSKGAPFRQPLYTNGATRTEEHCGQLFQVAAAGSGRLQLCGR
                     LHAGERAGPVSPSLPAVAAA"
     misc_feature    282..3173
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3173
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1784
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1944
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2065
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2190
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2351
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2468
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2548
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2701
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2798
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3022
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3174
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3270
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3652
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caaggtctta gaggagggtt cggctgcagg ctcagcacct gagacccagg
     1741 tcttggtggt aatgcgaccc ccacccaggg ggcctcagca acaggaagag tcaccagagc
     1801 cagtcagtgt cctccgccgc ttccccttct cctctgccct gcagcggatg gacgtggtgg
     1861 tgacatggcc aggggccacc cagcctgagg cctacgtcaa aggttcccca gagcttgtgg
     1921 ccagcctctg cagccccgag acagtgccca gagactttcc tcaggtactg cagagctaca
     1981 cagctgctgg ctaccgagtt gtggccctgg ctggcaagcc actgcccact gcgcccagcc
     2041 ttgaggccgc tcagcagctg acaagggaca ctgtggagca ggagctgagc ctcctggggc
     2101 tgctggtcat gcggaacctg ctgaagccac agacgacccc agttatacag accctgagga
     2161 agacgggcat ccgtactgtt atggtgacag gggacaacct gcagacagca gtcacggtgg
     2221 ccaaagcgtg tggcatggtg ggcacccagg agcacctggc tatcatccat gccacccacc
     2281 ctgagcaggg ccagcctgct gcccttgagt tcctgccaac tgagccctct gcggccatga
     2341 atggggcaaa ggatcctgtg caggccacgg actaccccgt ggagccggag tcccagtccc
     2401 gtcacctggc cctcagtggg tccacgtttg ctgtccttca gaagcacttc cccaagctgc
     2461 tgcccaaggt cctggtgcag gccaccgtct ttgcccgcat ggccccggag cagaagacac
     2521 agctagtgtg tgaacttcag agacttcagt actgcgtggg catgtgcggg gatggagcca
     2581 atgactgtgg ggccctgaag gcggctgacg tgggcatctc actgtcccag gcagaggcct
     2641 cagtggtctc tccgttcacc tccagcatgg ccagtattga atgtgtgccc actgtcatca
     2701 gggaaggccg ctgctctctg gacacttcat tcagcgtctt caagtatatg gccctataca
     2761 gcctgaccca gttcatctct gtcctcattc tctacacaat caacaccaac ctgggagacc
     2821 tacagttctt ggccatcgac ctgttcatca ccaccacggt tgccgtgctc atgagccgca
     2881 ccggccctgc actgaccttg gtgcgagcac ggccaccagg ggcgctgctg agcgtgcctg
     2941 tacttggcag tttgctgctg caggtggcct tggtggccgg catccagctt gggggctact
     3001 ttttggtcat agctcagccc tggtttgtgc ctctgaacag aactgtaccc gcacctgaca
     3061 acctgcccaa ctacgagaac acagtgatct tctctctgtc tggcttccag tacctcatcc
     3121 tggccgcagc ggtgtctaag ggggcaccct tccgccagcc gctctacacc aacggggcca
     3181 ctaggactga ggaacattgc ggacagctct ttcaagttgc tgctgctggg tctggtcgcc
     3241 ttcaactttg tgggcgcctt catgctggag agcgtgctgg accagtgtct cccagcctgc
     3301 ctgcagtggc tgcggcctaa acgggcctcc aagaagcaat tcaagcagct acaacgggag
     3361 cttgctgaac gtccatggcc cactctgccc gttggctccg tgaggtagtg caggccttgg
     3421 agggcatgct ggacactgga tctccctgcc cctgagccat gaccggaact ctccctagag
     3481 acagtaccag tcacctccca cagccctgag gttggctgtc acactcctgg ggacacactc
     3541 gcctggggag gcgttgattg ttgcctcact gtgtagagac agcagctacc aactccatcc
     3601 ggagcagctg tcatggagca aataaagtgc cggctttcct gtcttggcag ca
//
LOCUS       NM_001107214            4753 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus SLAIN motif family, member 2 (Slain2), transcript
            variant 1, mRNA.
ACCESSION   NM_001107214 XM_001076917 XM_223362
VERSION     NM_001107214.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4753)
  AUTHORS   van der Vaart,B., Manatschal,C., Grigoriev,I., Olieric,V.,
            Gouveia,S.M., Bjelic,S., Demmers,J., Vorobjev,I., Hoogenraad,C.C.,
            Steinmetz,M.O. and Akhmanova,A.
  TITLE     SLAIN2 links microtubule plus end-tracking proteins and controls
            microtubule growth in interphase
  JOURNAL   J Cell Biol 193 (6), 1083-1099 (2011)
   PUBMED   21646404
REFERENCE   2  (bases 1 to 4753)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2025 this sequence version replaced NM_001107214.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.54472.1,
                                           SRR26643289.34850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               JAXUCZ010000014.1  35658055-35658639   c
            586-734             JAXUCZ010000014.1  35625581-35625729   c
            735-899             JAXUCZ010000014.1  35616392-35616556   c
            900-1061            JAXUCZ010000014.1  35610375-35610536   c
            1062-1421           JAXUCZ010000014.1  35607776-35608135   c
            1422-1559           JAXUCZ010000014.1  35607151-35607288   c
            1560-1637           JAXUCZ010000014.1  35599683-35599760   c
            1638-1953           JAXUCZ010000014.1  35594024-35594339   c
            1954-4753           JAXUCZ010000014.1  35590050-35592849   c
FEATURES             Location/Qualifiers
     source          1..4753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4753
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /note="SLAIN motif family, member 2"
                     /db_xref="GeneID:305310"
                     /db_xref="RGD:1311593"
     exon            1..585
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /note="upstream in-frame stop codon"
     CDS             197..2020
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /note="isoform 1 is encoded by transcript variant 1; SLAIN
                     motif-containing protein 2"
                     /codon_start=1
                     /product="SLAIN motif-containing protein 2 isoform 1"
                     /protein_id="NP_001100684.1"
                     /db_xref="GeneID:305310"
                     /db_xref="RGD:1311593"
                     /translation="MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQSAGLL
                     GPGSPARAGVSTPSSGAASPRGFPLGLGAKASGGAGSGPRRTSSEDLRDATSLLAAGE
                     GGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPS
                     PDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYSSPYSPNASSPYSSGFNSPSST
                     PVRPPIVKQLILPGNSGNFKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDV
                     TDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSMHH
                     AVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRASPQPMISRLQQPRLS
                     LQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQP
                     QASATSQRLKSLPRTPLKAKQVLPTPSTNRVPSPGKFRSPAAPSPLALRQPVKAFSNH
                     GSGSGSQETTQFTQTTSSPGPPVVQNTAPANPSSNINSATLTRPAGTAAMRSGLPRPS
                     APSAGGIPVPRSKLVQPVRRSLPAPKTYGSMKDDSWKDGCY"
     misc_feature    584..2017
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /note="SLAIN motif-containing family; Region: SLAIN;
                     pfam15301"
                     /db_xref="CDD:464627"
     misc_feature    584..2017
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /note="SLAIN motif-containing family; Region: SLAIN;
                     pfam15301"
                     /db_xref="CDD:464627"
     exon            586..734
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            735..899
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1061
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1421
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1559
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1637
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1953
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..4753
                     /gene="Slain2"
                     /gene_synonym="RGD1311593"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgcggag ccggcgcaga tgaggcggct cggctggggc cagcggcgct tcgcaacccg
       61 agccgggggg accctggcgg tggggcctgg ccctgctcta tgccggcgcc tcggctagcg
      121 tgagcggtgg cggtaacgcc tctctccccc gtgcttcccc tgcggcttgg gagtcggagc
      181 gggcggcgcg gccggcatgg aggacgttaa ctccaatgtg aacgcggacc aggaggtgcg
      241 gaagctgcag gagctggtga agaagctgga gaagcagaac gagcagctga ggagccgctc
      301 aggagccgtg cagagtgcag gcctcctcgg gccgggcagc cctgctcggg ccggcgtgtc
      361 caccccctcc tcgggcgcgg cgtcccctcg gggcttcccg ctgggcctgg gcgccaaggc
      421 gagcggcggg gcgggctcgg gcccgcgacg gaccagcagt gaggatctgc gggacgccac
      481 ctccttgctg gcggctggtg agggcggctt gctggacgag gtagaaccgc tgcggcccga
      541 cgagctggag cgcttgtcag gctgggagga ggaagaagag agctggttgt actcatcacc
      601 aaagaaaaaa ctcacaccaa tgcagaaatc tgttagtcca ttagtttggt gcaggcaagt
      661 tttggattat ccaagtcctg atgtggagtg tgctaaaaag tcccttatcc acaaacttga
      721 tcaaactatg tcagctctca agaggcaaaa tttatacaat aatcctttca actctatgag
      781 ttactcaagc ccttatagtc caaatgccag tagcccttac agcagtggct tcaactctcc
      841 atcctcaaca ccagtgcgac ctcccatagt caagcagctt atacttcctg gaaattcagg
      901 taacttcaag agctcatcag atagaaaccc tccactcagc cctcagtcct ctatagatag
      961 tgagttaagt gcttcagaat tagatgaaga ttcaattgga tccaactata agctaaatga
     1021 cgtaactgat gtgcagattc tagcccggat gcaggaagaa agtctccggc aagagtatgc
     1081 agccaccacc tctcgtcgca gctcaggctc atcttgcaac tccacgaggc ggggcacgtt
     1141 cagcgatcag gaactggatg cacagagctt ggatgatgaa gacgacagca tgcaccatgc
     1201 cgtgtaccct gctgttaata ggttttctcc atccccacgg aattcacccc gaccatctcc
     1261 taagcagtcg cctcgaaatt cacctcgttc acggtctcct gcccggggaa tagaatacag
     1321 tagagcatcc ccacagccta tgattagccg cttgcagcag cctcgccttt ccctccaagg
     1381 ccatcccaca gatttacaga caagcaatgt taaaaatgaa gaaaaactta gacgcagtct
     1441 tccaaaccta tcccgaacat cgaacacaca ggttgactcc gtgaaaagca gtagaagtga
     1501 ctccaatttt caagtgccaa atggaggaat acctcgaatg cagcctcagg cttcagccac
     1561 ttctcaaagg ctgaaaagtt tgcctcgtac tcccctcaaa gccaaacagg tgcttccaac
     1621 tccatctaca aacagagtac cttctccagg caagttccgc tcccctgcag caccatctcc
     1681 attggctctt cggcaaccag tgaaagcgtt tagtaaccat ggctctggtt ctggtagcca
     1741 agaaactaca cagttcacac aaaccacctc ctcacctggg cctcccgtgg tgcagaacac
     1801 agccccggca aacccttcca gcaatatcaa cagtgccact ctaaccagac ctgcagggac
     1861 agctgcaatg agaagtggcc tgccccggcc tagcgcccct tctgcggggg gcataccagt
     1921 gcctcgcagc aagcttgtgc agcctgttcg aagatcattg ccagctccta aaacctatgg
     1981 tagcatgaaa gatgacagtt ggaaagacgg ctgttactga ccagcagaga caaggataca
     2041 gacgtccaca gcttcatgga caccccttca ccaagctgaa accaactttt atatgcagac
     2101 tcttcagtga gactcttggg tttgcacact cccagcctct ctgtcttaat agcacaagtg
     2161 acggagacga ggaagcagca ctttaatgcc acgtgacatc agatgtgttt ggtagtcatg
     2221 cagtcactct ccatggggtc gcctagtttt gttcacttga agcacggttc attttattat
     2281 ttgacagagg ccaatatctg ggcaaatacc tactggatgc caaagagaat gcccatttgt
     2341 aaagagagaa cctgtgtaca tgggaagatg gtgaacttag gctatccaaa acctcacgtt
     2401 caacctactt tactgtacaa atagtatcaa taaatactgt gttaacaaga actaatattc
     2461 tgactaatta gactgttttc ttagtccttc aggatacagt aaattataaa gattgggaga
     2521 gagaaaggac agacctgagc taaagactca aaacgtgcta ctacctgtgt ttaggaaggt
     2581 tttatacatt acttttgcag actccgtggg aaaaggctct tagcttttaa acatagctca
     2641 catagccacg tgcagatggt gtcacagtgc acgcccaccg ccctacatct cagacttctg
     2701 tgtacctgtt tttgatgcca gaagggctca ctctctttct aactttacag ttcctggctc
     2761 aggacagatg gcctttgctg ttgaagccaa cttactcaca tgctggtttc tgtctgtcac
     2821 agagctgaaa gagctgtttc cacaccaggt ttctatgatg tcaaagaaca gttacgtgtc
     2881 tttgtccttg acaaagcaac acctcagaac ttagagcctg gagtagaacc atatccaaga
     2941 ggagggaaat ctatgcacta actgtaaaca tctctgtgat ggcagctgta ctgctgctcg
     3001 taagcggcag cgcggtctgt tatgtggtag tcagtccact ccaaactgaa tgactgtatg
     3061 aagtcccttt ttaaaaccct gtccctttaa cttagattct gccttacatc agcgttttca
     3121 ttgtttggtt acaaagcatc caactctact ttgctaaata cttgctcttt aaatggcata
     3181 tgtgtgtata taacccttgg aattagctgt ttggtttttc agattattat caaactataa
     3241 ctcgagctga cttctcattt tttataatga ggtctgtttt ttaaatactt aatacagttt
     3301 taaatgttgg cagttgggtc acatagaggc ggggtatttg aactcgtttc ctgtaagtag
     3361 aggatgttct ataaagtgca cgtagaaata cagagaggaa gggaagggaa gtttcctgct
     3421 caggaaagca tcgatttgat gataacagag accccgtctg ccatggctga cgctggccca
     3481 gcagggagac atggagcgca gacagcacga gtgccagacc tgtagtatag ggtggaagac
     3541 attgaaggga tgtgagggaa ggaggctgcc ccgtcgggtg ccccgtcatc catgatgctg
     3601 gactgagaac agctgtttct tccagaaaga cggagcgcgt gctttggcct gctgagagcc
     3661 agagagcagc ctcggtctct gcagagcctc acgtgcacac agcaagcagg tctctgttca
     3721 gtgtgacggt tggaaataat aaatgctgca atctaataat ttaaaagaac ctttaatgaa
     3781 ccatctatca catttttaag ttagataatc agtttcaaaa ggaacattca ggttatttaa
     3841 cattgttttt aaatggctgc atcagaacaa atatctattt ttttttaatt aaactatttc
     3901 atcacttgtt taaaaatgta ttttggatct gagtttggtg atattatttc agctgctgct
     3961 gcactaccac agattattat tggcttttag tttcctaaag agaaaaattg cctttttact
     4021 agaaagcctt tgtgtattgc cagtttttct gtttgggaaa atctaaggat ttactgtggt
     4081 tagtcgtaca gaagaaatgt ggatttgatg aactagtgcc tatgatttta acttatgttt
     4141 gatatatagt agtagggtca taaatgttga ttattttgtg ccaacagccc agaattgtca
     4201 cttgtatgtc agcagaaact atgacctctg cttccaaagt tatttaattt tctcagtgtt
     4261 tggatgttat tttttgtaag tgtgttaata aaagtgtaaa gaattggaaa aatataaata
     4321 ttcttaactc aagcatttgc tgaatcattt ttctacaaaa cttgtttgta caaaactctg
     4381 tgaagagttg acttttctca gttttcatac cctggaaatc acattttgta aaactgggga
     4441 ccattcataa ttgtcagata cttttttaaa ttatctcaga acatcacttt tatatataga
     4501 tataaaaatt tttttgaaag caaagaaaat taaatacata tgtgtcccca gatatttgta
     4561 caactctagg atgatctaga ctgtgtatgt tcagatcgac gtaactcact gtacagatgc
     4621 ccagctttga cagatgatgc atggtcctta gagcacatga agtttgattt gcaaacattt
     4681 ctatagctgc acttgtaata tgtggttgcc tccttaataa acagcctgac catgatgttt
     4741 attattaaat cta
//
LOCUS       NM_001191871            7420 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 40
            (Zbtb40), transcript variant 2, mRNA.
ACCESSION   NM_001191871 XM_342953
VERSION     NM_001191871.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7420)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   2  (bases 1 to 7420)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 7420)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced NM_001191871.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000005.1  154567023-154567177 c
            156-263             JAXUCZ010000005.1  154555959-154556066 c
            264-1012            JAXUCZ010000005.1  154537110-154537858 c
            1013-1146           JAXUCZ010000005.1  154536331-154536464 c
            1147-1303           JAXUCZ010000005.1  154527026-154527182 c
            1304-1446           JAXUCZ010000005.1  154526335-154526477 c
            1447-1639           JAXUCZ010000005.1  154520544-154520736 c
            1640-1720           JAXUCZ010000005.1  154520237-154520317 c
            1721-1857           JAXUCZ010000005.1  154518824-154518960 c
            1858-2059           JAXUCZ010000005.1  154517866-154518067 c
            2060-2193           JAXUCZ010000005.1  154517219-154517352 c
            2194-2362           JAXUCZ010000005.1  154515400-154515568 c
            2363-2821           JAXUCZ010000005.1  154514633-154515091 c
            2822-3028           JAXUCZ010000005.1  154513780-154513986 c
            3029-3193           JAXUCZ010000005.1  154510949-154511113 c
            3194-3411           JAXUCZ010000005.1  154509221-154509438 c
            3412-3574           JAXUCZ010000005.1  154508168-154508330 c
            3575-3661           JAXUCZ010000005.1  154507481-154507567 c
            3662-3888           JAXUCZ010000005.1  154505013-154505239 c
            3889-7420           JAXUCZ010000005.1  154499950-154503481 c
FEATURES             Location/Qualifiers
     source          1..7420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7420
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="zinc finger and BTB domain containing 40"
                     /db_xref="GeneID:362635"
                     /db_xref="RGD:1309866"
     exon            1..155
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            156..263
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1012
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="upstream in-frame stop codon"
     CDS             316..4083
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger and BTB domain-containing protein 40"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 40
                     isoform 2"
                     /protein_id="NP_001178800.1"
                     /db_xref="GeneID:362635"
                     /db_xref="RGD:1309866"
                     /translation="MELPNYSQQLLLQLYALCKEQRFCDCTISIGNIYFRAHKPVLAA
                     ASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFSKIISLADSLQM
                     FDVAVCCKNLLTNLVNCSVQGQVVRDISVLSSEAGGKESEKPQVEVLSSEGAGEPSSS
                     LEVSAMPAGTEKAKTQEVIHMVTQEISADPPIAQEVQVAAEITGATPHTTEVCSPLPA
                     GQIPSEAKAASTEAGCERKQDQLTLLLEYESVFSSAALLTPDMLRRLEGCSEIEGPQK
                     ETVMECLEAEGGGSAFQRILDKVHDGSLDVQVALSLMRLCQESTPAEKVSQIEGSAGE
                     GKTLSVLLLEHKEDLIQCVTQLRPIVEFLETAKEEFLPDSEKRVIQICCEGRTPKETV
                     ENLLHRVTEEKTLPAKSLVKLLQAVRTAFPNLGLLLENLQKVAESPGTTGLTRATRET
                     AWTEEPKRLCIPADRVDGSSPNPDAYGAELLRKYHENLSEILIDSQVLLKVISRLKSL
                     APGDREVMQTLVKQDSGSGGVSSLMSAALERQTVSAAAIWQLLLAAQETETCPLNLLL
                     EEVEREPGAGAFFRAVTAPESTVLETILRHSKLVREAIQQTVGREHLSSEEEHLAETV
                     KEMLSISSETVSPEASLRVVLSRAMEKSVSASVVCHLLCSVHRSFPGLQPLMQELAHV
                     GFLTKENAEERWKVTDGLHPGAKDKTEEAAEAAREDGRAMEQKEQGPEPVPERQEKDT
                     SASPDAAKKSFVCKACDKSFHFYCRLKVHMKRCRVAKSKQAQGKGDSDTRDSEKELGR
                     QQPEARSAGAEPDAPKKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDEKPFSCEEC
                     GAKFAANSTLKNHLRLHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCD
                     AVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHTDIEDPYDCKKCR
                     MSFSTLQDHRKHIHDVHSKEYHPCPTCGKIFSAPSMLERHMVTHVGGKPFSCGICNKA
                     YQQLSGLWYHNRTHHPDVFAAQNHRSPKFSSLQCSSCDKTFSNTIEHKKHIKTEHADL
                     KFHECGQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQ
                     SESTFPCELCGELFTSQAQLDGHLESEHPKVTGTETQAAASRMVQVIQAPEPAAPAEQ
                     VITLEETQLAGSQVFVTLPDPQTSQNSSELVAVTVEDLLDGTVTLICGEAK"
     misc_feature    316..663
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 40 (ZBTB40); Region:
                     BTB_POZ_ZBTB40; cd18225"
                     /db_xref="CDD:349534"
     misc_feature    316..663
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 40 (ZBTB40); Region:
                     BTB_POZ_ZBTB40; cd18225"
                     /db_xref="CDD:349534"
     misc_feature    2785..2850
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2785..2850
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2872..2934
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2872..2934
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2887..2889,2893..2895,2899..2901,2905..2910,
                     2917..2922,2929..2931,2971..2973,2977..2979,2989..2991,
                     3079..3081,3088..3093,3100..3102,3142..3144,3148..3150,
                     3154..3156,3160..3165,3172..3177,3184..3186)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2887..2889,2893..2895,2899..2901,2905..2910,
                     2917..2922,2929..2931,2971..2973,2977..2979,2989..2991,
                     3079..3081,3088..3093,3100..3102,3142..3144,3148..3150,
                     3154..3156,3160..3165,3172..3177,3184..3186)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    <2920..3681
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <2920..3681
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    2956..3105
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2956..3105
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3127..3186
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3127..3186
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3217..3273
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    3217..3273
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    3385..3447
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3385..3447
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3505..3564
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3505..3564
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3592..3657
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3592..3657
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3679..3738
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3679..3738
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3772..3825
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3772..3825
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1013..1146
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1303
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1446
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1639
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1720
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1857
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2059
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2193
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2362
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2821
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..3028
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3193
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3411
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3574
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3661
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3888
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..7420
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggccctgg gcgtccccgg ccccaagatg gctgcctttt ggcgtctcca gcgctgttga
       61 atggagaaag ctttattgtt cccttcgggc aggagtgttc gtgttctcta tggcgctgtc
      121 aataaagaac ggcagtttga atcggtactg aacagacaga aactcaagta tcctagagtc
      181 acttcaaact gtgtgtccaa ggacaacttt aaacttcgga tcctcctccc tctacgtctt
      241 gagttccggg tttacgatta ttggacttgg tggagtctga aggtctagag gaagggttcg
      301 agggtggccc acaccatgga actccctaac tacagccagc agctgcttct gcagctctac
      361 gccctgtgca aggagcagcg gttctgtgat tgcaccattt ccatcggcaa catctacttc
      421 agggcccaca agccagtcct ggcagcagcc agcctcctgt tcaaaaccct gctggatagc
      481 acagatgcca tctccattga tgcatcagtg gtgagccctg aagagtttgc cctcttgtta
      541 gaaatgacat ataccggcaa gctacctgtg ggcaagcaca acttctccaa gatcatctcc
      601 ttagcagata gcctgcagat gtttgacgtg gctgtttgtt gtaaaaatct tctgaccaac
      661 ctcgtaaact gctctgtcca ggggcaggtg gtaagggata tctcagtgct gtcctcagag
      721 gcaggtggca aggaatcaga gaagcctcaa gtagaagtcc tttcctctga aggtgctggg
      781 gagccctctt cttccctgga agtttctgcc atgccagcag gcactgagaa agccaagacc
      841 caggaagtaa ttcacatggt tactcaagag ataagtgcag accctcccat tgcccaggag
      901 gttcaggtgg ctgcagagat cacaggggca actcctcaca caaccgaagt ttgttcccct
      961 ctccctgctg gacagatccc aagtgaggca aaggcagcca gtacagaagc agggtgtgag
     1021 aggaagcagg accaactgac tctcctgcta gaatatgaaa gtgtcttctc aagtgcagcc
     1081 ttgctcaccc cggacatgct gaggagactg gaaggatgct ctgagattga agggcctcag
     1141 aaggagaccg taatggaatg tctcgaggcc gaaggaggag gctcagcatt ccagagaatc
     1201 ctggacaaag tgcatgatgg gagcctggat gtgcaggtgg ccctgtctct gatgagacta
     1261 tgccaggagt ccacacctgc agagaaagtg tctcagattg aagggagcgc aggagaggga
     1321 aagaccttgt ctgttctgtt actagaacac aaagaggacc tgatccagtg tgtaacacag
     1381 ctcagaccta ttgtggagtt cctggaaaca gccaaggagg aattcctgcc agactcggaa
     1441 aaaagggtga ttcagatctg ctgtgagggc agaacaccca aggagacggt agagaatttg
     1501 ttgcacagag tgacggaaga gaagaccctg cctgccaaga gtctggtaaa actccttcag
     1561 gctgtgagga cagcattccc aaacctgggc ctcctgctgg agaatttgca gaaagtagcg
     1621 gaatcacctg gcaccacagg cctgaccaga gctacccgtg aaactgcatg gacagaggag
     1681 cccaagagat tgtgcattcc agcggaccgt gtggatggat cctcccccaa ccctgatgcc
     1741 tacggagccg agctgttgag aaagtaccat gaaaacctgt ctgagattct catagacagc
     1801 caggtgctgc taaaggtgat ctcacggctg aagagcttag cccccggaga cagagaggtc
     1861 atgcagaccc tcgtgaaaca ggactctggc tcgggtggcg tcagttccct gatgtcagca
     1921 gctctggaaa ggcagactgt ctctgcagcg gccatttggc agctgctgct agcggctcaa
     1981 gagaccgaga cctgcccgct gaacctgctg ttagaggaag tagagaggga gcctggcgct
     2041 ggggcttttt tccgggcagt aactgcccca gagagcacgg tgttggaaac catcctgagg
     2101 catagcaagc tggtccgcga ggccatccag cagacagtgg ggcgtgaaca cctttcttca
     2161 gaggaagagc acctggcaga gactgtgaaa gagatgctga gcatatcctc cgagacggtg
     2221 agccctgaag cctccctgag agtggtgctg agcagagcca tggagaaatc cgtctcagcc
     2281 tctgtggtct gtcacctcct atgcagtgtc cacaggtctt tccctggcct gcagcccctc
     2341 atgcaggagt tggcacatgt tggtttcctt accaaggaga atgcagagga gaggtggaag
     2401 gtgaccgacg ggcttcaccc tggagccaag gacaaaacgg aggaggcagc tgaggcagcc
     2461 agagaagacg gccgggccat ggaacaaaag gagcagggac ctgagcctgt gccagagcgg
     2521 caggaaaaag acacttctgc ctccccagac gctgccaaga agagcttcgt ctgcaaagcc
     2581 tgtgacaaga gcttccattt ctactgccgt ctgaaggtgc acatgaagcg ctgccgggtg
     2641 gccaagagca agcaggcaca gggcaagggt gacagtgaca ccagggactc ggagaaggag
     2701 ctggggaggc agcagccgga ggcccgcagc gcgggtgcag agcccgatgc tcccaagaag
     2761 aagaagaagc gactgccagt gacatgcgac ctctgcggaa gagagttcgc ccacgcctca
     2821 ggcatgcagt accacaagct gacggagcac ttcgacgaga aacctttctc ctgtgaggaa
     2881 tgtggggcaa agtttgcagc caactctacc ctaaagaacc acctgcgcct ccacaccggg
     2941 gaccgcccgt tcatgtgcaa gcactgcctc atgaccttca cacaggcctc ggccctggct
     3001 taccacacca agaagaagca ctcggaaggg aaaatgtacg catgccagta ctgtgatgct
     3061 gtgttcgccc agtcgatcga gctgtctcgg catgtgagga cccacacggg ggacaagccg
     3121 tatgtctgta gggactgtgg aaagggcttc cggcaagcca acggcctctc catccacctg
     3181 cacaccttcc acacagacat agaagatcct tatgattgca agaaatgcag gatgagcttc
     3241 tccacactgc aggatcaccg gaagcacatc cacgacgtgc actccaagga gtaccacccc
     3301 tgccccacat gtgggaagat cttcagtgct ccttccatgc tggagcggca catggtgacc
     3361 cacgttggag ggaagccctt tagctgtggg atctgcaaca aggcctatca gcaattgtca
     3421 ggtctatggt accacaaccg gacacaccac ccagatgtgt tcgctgctca gaaccatcgg
     3481 tcacccaagt tctcatcact gcagtgcagc tcctgtgaca agaccttttc caacaccatc
     3541 gagcacaaga agcacatcaa aacagagcac gcagatctga agttccatga gtgtggccag
     3601 tgtaaggagc tcttccccac accagctctg ctgcaggttc acgtcaaatg tcagcattca
     3661 gggtcacagc cattccggtg cttgtactgt gcagccactt tccgcttccc tggagcactg
     3721 cagcaccacg tcaccacaga gcacttcaag cagtcagaaa gcaccttccc ctgtgagctc
     3781 tgtggcgagc tcttcacctc ccaggcccag cttgatggcc acttggagtc tgagcaccca
     3841 aaggtgacag gcactgagac ccaggcagct gcctctcgca tggtgcaggt gatccaagct
     3901 ccagagccag cagccccggc cgagcaggtg atcacgttgg aggagacgca gcttgctggc
     3961 tcacaggtgt ttgtgacctt gccagaccca cagacctccc agaacagctc tgagcttgtg
     4021 gcagtgacgg tggaggattt gctggatggt actgtcactt tgatctgtgg tgaagccaag
     4081 tgagtggctg ctccttcagt agaggagcct gtgttggacc agcacggatg cccacggcct
     4141 acctctgctg cttagctaag ctccaccctg gtgctctcac ggggaagaca gaggctttgt
     4201 cattttcctg ggatccagtg tctgagctaa ccacactggt gccagcacta ctgcccttcg
     4261 tggcagagag cctcagtcct ccaggcctgc attcccccac cccagggaag tctggcttct
     4321 ggagtcagag tctgagggaa tccagggtga ccaaggagat acagcatgct ggccgccctc
     4381 aggagcaggg cagttacctg agtctgagcc aacagggggc cacagacacc accagtgcct
     4441 ctgccagtaa agcacccaca cagcctccag ggaccccagc gtggcagctg tcctccctcc
     4501 acccctgccc cagctcgggt tccctttgga ggctgtaaaa cacgcgttaa cagtgcaggt
     4561 ctccattggc ttccccaatc ctccctgctc tgtctttctc aaaacaaagc tttgagcatt
     4621 gccactgggg ggccgcttcc tgtgaggtca cccagctgcc tctgccttcc tgggtgttca
     4681 tcagagcctc cctgtgagct tcaggccttc cacatctgct aatcaaggct gaactgcctc
     4741 agcccggaga cctcttgctg acttcctctg taccgtgtga tagcctaatg aaccagcttg
     4801 tgggggcagg cctgtgcctg catgtgatgg attagcagca tctgaggtgg cctctgcttc
     4861 tcctgtcact ggcctgcatg tctggtgcat ggcctgctct ctgggatccc caggctgcat
     4921 acttactgca gcaccatgct tctttcaagt ctgagtgtcg cagagcctct catccttagt
     4981 tcctgacgtg cggtctgtaa ttgatggctt gtggaatccg gttggaaggg caattagatg
     5041 gatgttggtt cctgctgctt agagagaagg gcttgcattt atcttacctt tctagaagcc
     5101 tgaagagagg agtgggttat cacagtattt gcccatctgg cccggctccc tgtcacctgt
     5161 gtggctgact ccctacagtg ggaacaccct gatttggtac tcacctttag ccacctgcta
     5221 taagataagc ccacagcttc ctgccaggtg cagctcacat gagcttgtgc agagatgtgg
     5281 gtccagtgtg gccatggtga aggtgcattg cccccatccc tcagctgcct cacaggagga
     5341 cacaaagtag cagcgtaacc cacagcagtg tctaagggct gctgcccttt ggcctcagct
     5401 tggcacaggc agtactggtg agtgtctaag ctggacacca gctctggcca gcctctcctg
     5461 tcaaccctgc cctcctcatt ccagatgcaa atcgtttgaa cttaccagct agggaatcct
     5521 ccctttctaa aagtcaatgt ttttcaaacg tgtcagcctc agaaaccaaa cactgaccag
     5581 aagatggtgc tcaagcatca aaacttcacc tccctggttt ctccactgca gtcctagcct
     5641 gctggctttc agacctgtgc cagccgacca ggggagctct tgatctctaa gtggtgtaac
     5701 agttcctcag tccatctgcg tcaagtaacc cactaaaaga cagcggaggg gcacatgtgt
     5761 ccaggccctg tcaggaacag cacgtcacag gctgtggagg acttaggaac tgtgtagtga
     5821 gtgtcaccaa aaagtctctt cctggtgaca ggcaaacctt gcagaggtcc tgtgtgagaa
     5881 agtccatttt taaatataaa gagctgtaag ttagaagcct gaatgtcagg ccctttccag
     5941 cctgagaaac agtctccgtt ttcctgggac ctgggtggtg tgcacgtatg tgcagtcagc
     6001 agacatggtt cactacagag agccttgggc aggtaggctt gctgcccttc cttggatgcc
     6061 cagctctgga atacacacgg ctggaggcac agcagtgctg ggtgtggagt atggagaact
     6121 cctgtcttcc acgagttctg tgctggtgac gtgtgacctc tgccccagct gctgactttt
     6181 tacagtggct ctgaagaagg tgaaagtctc cacctactgc cccagagaac agccacatgg
     6241 gcctccttag tccacattgc ttttgcaatg gaaatgtggt tccatttgcc tcatcttctt
     6301 gaatactgcc tgcctagccc ttgggcagca gctccagcag tctgtgggtc ccttggaact
     6361 tgtgtatttg agcagtggga ccccaactca gccaccaaag aggggaaggc agatgccaag
     6421 ctggagtcca gttggcccat cactggtgta aggacagcaa actggtgact gaagagcagc
     6481 ctactgtcag caggagagag ctgctgtcct actgtcagca ggagagacct gctgtcaatg
     6541 cacgagcaga acctaggcca gcgcggcaga taaaggtctt tctcgggtgt tttacaagac
     6601 tggactcttc tgtcttctaa gctgtacgtc ggaaaagctt tgagctcagt ccgtacccaa
     6661 gcctgtgatg tgagttctgg gcctgtgtgt tgtactggcc catgctgacc acaggagagg
     6721 cctcagcctt gtccctgagc actgatggtt agggctggga tgaggggcag acagatgcca
     6781 aatgagggga aagagctctg tgtcctgggg acaggagggt gggcctttac atttcttgtg
     6841 cctgggaacc tgagctgaca ggacggagca ctaaggccca cttagcgtgc gctcgttggg
     6901 aacagcagtg cctttcggag ctggaaagtc ggccagtggt ggagatgaca ctggtttgct
     6961 ccagtcagcc tctcccatcc cagctttgtt ctgggtcctg tgtgtcccag cagatgacac
     7021 tcagaaggga ttgggagtaa atgacttagg gctgaggggg tcaaaggcag gttcacagtt
     7081 ttgttgctgt ggaaaccttg ggggcactga gaactacgct aaaaactacg gacctcaaac
     7141 ttactcagtc taactgggcc tctagagaag aggggagtgg tgagttcttt gcggaccgat
     7201 ggtgttgttg aggaaatcat tccatgagca agtttacatc gtctccaaac ggtgaggctg
     7261 gccgtggttt ccctgagcaa ggctgctggt gcttgtttcc accatggcca agacagccag
     7321 ccccaggaga tgtgtgaact ggattgcaaa ctagaactgc tcaacatgca ctgtggctag
     7381 aaataaagtc tgctttggaa gcagttgtgg tttgtgtact
//
LOCUS       NR_199192               2970 bp    RNA     linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus glycoprotein alpha-galactosyltransferase 1
            (Ggta1), transcript variant 5, non-coding RNA.
ACCESSION   NR_199192
VERSION     NR_199192.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.12270.1,
                                           SRR26643294.12996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000003.1  39206544-39206720   c
            178-293             JAXUCZ010000003.1  39167649-39167764   c
            294-2970            JAXUCZ010000003.1  39154574-39157250   c
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2970
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="glycoprotein alpha-galactosyltransferase 1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     misc_RNA        1..2970
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /product="glycoprotein alpha-galactosyltransferase 1,
                     transcript variant 5"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     exon            1..177
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            178..293
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            294..2970
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagatc tgactgcctc tttcatttgc ctggaggtag ctaggtgtgt ctcaggaggc
       61 tggagattct gggtggagcc ctagtcttgc cttttcttag ccgagcgaca ccttcccttg
      121 tagactcttg gaatgagaaa taccgattct gctgaagacc tcactctcag gatctgggag
      181 ttggagccct gtaccttcct ttcctctgag ccctgtctcc ttcggcaggc gggagctcca
      241 tagaactcgg ttgctctgct gtttgctttg gagaggacac agcggacaat gagcctctat
      301 ttgcccgact caaagccctc gaacttctga gaaaccaggt gtggaaccag ctgaaggact
      361 cctatgaggc tggggacctg tccatacctc accagttcca agtgggagac acggtcctga
      421 tacggagaca tcgtgcgggg aaccttgaac cgcgctggaa gggaccctat ctggtactgt
      481 tgactacccc acggcagtga aggtggacgg gatccctacc tgggtacatg cctcacacgt
      541 gaagaaggct tccgcgtcca gtcaagatga atggactgtg gtgcagactg ataatcctct
      601 taagttgcgc cttcagcagg gggacgaaga gtcagagcaa cccccaccaa cccatgaccc
      661 taacgtggca aattgttgac gttgactcag gaaaagttat aaacagctcc cgaactagtg
      721 caccgccagg aacctggtgg ccggagcttg gattttgtct ccgggacata aatcctacgg
      781 ccaaaactaa cccccctaac ctgattcgaa gctatgggtt ttatgcttgc cccgggactt
      841 cagatgaacg gaaatgtggg gggtctagtg agtttttctg tagacaatgg gcctgtgtga
      901 cctccaacga tggagactgg aagtggaaag tcagccctac cgacctggta actctctctt
      961 ttgcaaacac tggacctggg agatacgtca tcctccctct ttatgcagga aaatcttgtc
     1021 atccctcaga tctagattat ataaaggtcc agtttacaga tatagggaaa aacactccca
     1081 tttctatttg gtctacttgg tcctactttt ggggaatagt ttacaataag tatggaaacc
     1141 aacctggatc cttgatccag attcaacaca caatggaaag tttgccatca ccccccagtg
     1201 ggccctaata aggtcctgcc tgattaaggg tctccaaaag ccctagcacc acctccgagg
     1261 tcaaaaagcc ccagtaactc ccccagcagc tccacccgtg aaagtgtcca catcccctcc
     1321 caggggacat aaaagcagta ctagctctcc agtcactagt gtaccttcta ctctgtctac
     1381 ccttatgttt actgtgcctt cccccattac taggcaccct tccactggag atagactgtt
     1441 taatctcatc cttgggggct acaagctctc aaccaatcca atcctaatga cacagagtcc
     1501 tgttggcagt gtctaatgga cagtccaccc tattatgagg gtatagcgct ggtagggaac
     1561 tacagtaact ctagctcaca tggtgaatgt gcttggtagg accagggcac actaaccatc
     1621 actgaagtct ctggttcagg gctatgcctg ggtaaggtcc ccccgagcca ccagtatctc
     1681 tgtaaccaga cctctctgag cccaaccact acccagaatt attatctagt accccctaat
     1741 ggaacctggt gggcctgtaa tactggcctc atcccctgtg ccgctaccag agttttcaac
     1801 aactctagag actattgcat tcttatccag cttttgccta agattatata ccatgatgcc
     1861 ccagggttca aggacctgtt tgaccggaga gtaaccaggt ataggaggga acccatctcc
     1921 ctcactctag ctgtgctatt gggattagga gtgacggccg gagtaggtac aggggctgcg
     1981 gccctggtaa cccagcatca agggttctta tccttacagg cagctattaa tgaagatctt
     2041 agagacctac aaaattctat cgaggctcta gagaagtctc tgacttccct ctctgaagta
     2101 gttttacaaa acagaagagg acttgacctc ctatttctta gagaaggggg actgtgtgcc
     2161 gctttaaagg aagaatgttg cttttatgct gatcatactg gggtggttag agactctatg
     2221 caaagactca aagagagatt agataaacga cagagggacc gtgaggcaca acaaggatgg
     2281 tttgagtctt ggttctccca ctctccgtgg ctgaccactg ttgtctactt tggccgggcc
     2341 cctggtgcta ttgcttctgc tacttacctt tgggccttgt gtgattaata ggcttgtagc
     2401 ttttgttaga gaaaggatta gtgctatgca actattactc ctcagacaac aatataaggc
     2461 tttgcaaaat cctgaagatg agctgtaatt ctaagtttta gaattattta ctagaagaag
     2521 tggggaatga aatgttgttc aaaaactcgt ccctgtcgcc cacccactca aggcctgaac
     2581 ctggctttca gcctgtacta gttaactctt acatgaccca tgtactggga agtttgtgtt
     2641 ccaggaactc agaggcgtcg tgagatcaga tagctgtact ccaagggtgt aaacgacctc
     2701 ctccaccctg taaccagagt ttcgagaaaa gccataaaga acatctgtgg gaccccagat
     2761 atcccttttg cccgctcaaa acttgcttaa gtttgaataa gcgcgaggac caatcatgta
     2821 ttgccctgcc atccttttcc cgctccttat ccaaaaccct atataaactc tgtgcttctg
     2881 tggttcgggg ccaatccctc tgcctcctgc gagaggtacg ttattggtcc agagctctgc
     2941 ccaaatacag cctgttgctt ttgcatcgaa
//
LOCUS       NR_199191               2984 bp    RNA     linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus glycoprotein alpha-galactosyltransferase 1
            (Ggta1), transcript variant 4, non-coding RNA.
ACCESSION   NR_199191
VERSION     NR_199191.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Fullmer,J.M., Riedl,M., Williams,F.G., Sandrin,M. and Elde,R.
  TITLE     Enzymes that synthesize the IB4 epitope are not sufficient to
            impart IB4 binding in dorsal root ganglia of rat
  JOURNAL   J Comp Neurol 501 (1), 70-82 (2007)
   PUBMED   17206613
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Taylor,S.G., McKenzie,I.F. and Sandrin,M.S.
  TITLE     Characterization of the rat alpha(1,3)galactosyltransferase:
            evidence for two independent genes encoding glycosyltransferases
            that synthesize Galalpha(1,3)Gal by two separate glycosylation
            pathways
  JOURNAL   Glycobiology 13 (5), 327-337 (2003)
   PUBMED   12626403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.11448.1,
                                           SRR26643287.7725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000003.1  39207771-39207961   c
            192-307             JAXUCZ010000003.1  39167649-39167764   c
            308-2984            JAXUCZ010000003.1  39154574-39157250   c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2984
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /note="glycoprotein alpha-galactosyltransferase 1"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     misc_RNA        1..2984
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /product="glycoprotein alpha-galactosyltransferase 1,
                     transcript variant 4"
                     /db_xref="GeneID:246766"
                     /db_xref="RGD:629476"
     exon            1..191
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            192..307
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
     exon            308..2984
                     /gene="Ggta1"
                     /gene_synonym="Ggta1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcccgc gccctaggcc gccgcgcgct gcccagagga ggcgccggca ggggccggag
       61 gcgcgcaccc cgcccggcac acccaggcgg agcagcgacc cggtctcctg cagcgcaggg
      121 cgccgcccgc gtgcgtggtc ctgtccccat cgcggccgac cgcacacgcc gggcctggtt
      181 ctgcagatca ggagttggag ccctgtacct tcctttcctc tgagccctgt ctccttcggc
      241 aggcgggagc tccatagaac tcggttgctc tgctgtttgc tttggagagg acacagcgga
      301 caatgagcct ctatttgccc gactcaaagc cctcgaactt ctgagaaacc aggtgtggaa
      361 ccagctgaag gactcctatg aggctgggga cctgtccata cctcaccagt tccaagtggg
      421 agacacggtc ctgatacgga gacatcgtgc ggggaacctt gaaccgcgct ggaagggacc
      481 ctatctggta ctgttgacta ccccacggca gtgaaggtgg acgggatccc tacctgggta
      541 catgcctcac acgtgaagaa ggcttccgcg tccagtcaag atgaatggac tgtggtgcag
      601 actgataatc ctcttaagtt gcgccttcag cagggggacg aagagtcaga gcaaccccca
      661 ccaacccatg accctaacgt ggcaaattgt tgacgttgac tcaggaaaag ttataaacag
      721 ctcccgaact agtgcaccgc caggaacctg gtggccggag cttggatttt gtctccggga
      781 cataaatcct acggccaaaa ctaacccccc taacctgatt cgaagctatg ggttttatgc
      841 ttgccccggg acttcagatg aacggaaatg tggggggtct agtgagtttt tctgtagaca
      901 atgggcctgt gtgacctcca acgatggaga ctggaagtgg aaagtcagcc ctaccgacct
      961 ggtaactctc tcttttgcaa acactggacc tgggagatac gtcatcctcc ctctttatgc
     1021 aggaaaatct tgtcatccct cagatctaga ttatataaag gtccagttta cagatatagg
     1081 gaaaaacact cccatttcta tttggtctac ttggtcctac ttttggggaa tagtttacaa
     1141 taagtatgga aaccaacctg gatccttgat ccagattcaa cacacaatgg aaagtttgcc
     1201 atcacccccc agtgggccct aataaggtcc tgcctgatta agggtctcca aaagccctag
     1261 caccacctcc gaggtcaaaa agccccagta actcccccag cagctccacc cgtgaaagtg
     1321 tccacatccc ctcccagggg acataaaagc agtactagct ctccagtcac tagtgtacct
     1381 tctactctgt ctacccttat gtttactgtg ccttccccca ttactaggca cccttccact
     1441 ggagatagac tgtttaatct catccttggg ggctacaagc tctcaaccaa tccaatccta
     1501 atgacacaga gtcctgttgg cagtgtctaa tggacagtcc accctattat gagggtatag
     1561 cgctggtagg gaactacagt aactctagct cacatggtga atgtgcttgg taggaccagg
     1621 gcacactaac catcactgaa gtctctggtt cagggctatg cctgggtaag gtccccccga
     1681 gccaccagta tctctgtaac cagacctctc tgagcccaac cactacccag aattattatc
     1741 tagtaccccc taatggaacc tggtgggcct gtaatactgg cctcatcccc tgtgccgcta
     1801 ccagagtttt caacaactct agagactatt gcattcttat ccagcttttg cctaagatta
     1861 tataccatga tgccccaggg ttcaaggacc tgtttgaccg gagagtaacc aggtatagga
     1921 gggaacccat ctccctcact ctagctgtgc tattgggatt aggagtgacg gccggagtag
     1981 gtacaggggc tgcggccctg gtaacccagc atcaagggtt cttatcctta caggcagcta
     2041 ttaatgaaga tcttagagac ctacaaaatt ctatcgaggc tctagagaag tctctgactt
     2101 ccctctctga agtagtttta caaaacagaa gaggacttga cctcctattt cttagagaag
     2161 ggggactgtg tgccgcttta aaggaagaat gttgctttta tgctgatcat actggggtgg
     2221 ttagagactc tatgcaaaga ctcaaagaga gattagataa acgacagagg gaccgtgagg
     2281 cacaacaagg atggtttgag tcttggttct cccactctcc gtggctgacc actgttgtct
     2341 actttggccg ggcccctggt gctattgctt ctgctactta cctttgggcc ttgtgtgatt
     2401 aataggcttg tagcttttgt tagagaaagg attagtgcta tgcaactatt actcctcaga
     2461 caacaatata aggctttgca aaatcctgaa gatgagctgt aattctaagt tttagaatta
     2521 tttactagaa gaagtgggga atgaaatgtt gttcaaaaac tcgtccctgt cgcccaccca
     2581 ctcaaggcct gaacctggct ttcagcctgt actagttaac tcttacatga cccatgtact
     2641 gggaagtttg tgttccagga actcagaggc gtcgtgagat cagatagctg tactccaagg
     2701 gtgtaaacga cctcctccac cctgtaacca gagtttcgag aaaagccata aagaacatct
     2761 gtgggacccc agatatccct tttgcccgct caaaacttgc ttaagtttga ataagcgcga
     2821 ggaccaatca tgtattgccc tgccatcctt ttcccgctcc ttatccaaaa ccctatataa
     2881 actctgtgct tctgtggttc ggggccaatc cctctgcctc ctgcgagagg tacgttattg
     2941 gtccagagct ctgcccaaat acagcctgtt gcttttgcat cgaa
//
LOCUS       NR_199193               1046 bp    RNA     linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 6, non-coding RNA.
ACCESSION   NR_199193
VERSION     NR_199193.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.433991.1,
                                           SRR26360181.1412134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000009.1  21074406-21074500
            96-522              JAXUCZ010000009.1  21079517-21079943
            523-1046            JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1046
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     misc_RNA        1..1046
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /product="ciliary microtubule inner protein 3, transcript
                     variant 6"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..95
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            96..522
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1046
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccctcc cgagactccc cagatgcctc tggatcccta accaccagaa gttccatttt
       61 accatcaaag aggaaactga ccaaagatgt tgaaaataat agacacaaaa gatggatcac
      121 gcggttgtca ctaccaaaag tggactttgg agcgaacgga aaaggcgaga gcttgaaggg
      181 agagtgactc cgaaggtcac ttgggacggc tcttcaggag aaagagaatg aagacatgat
      241 agtgtcagga attggggagc gctgctccag aggccatagg gtggagggat gattggctgg
      301 aggaggaggg ggaggaagaa gagcactgaa gtcacaccca ggtctcccat cttctgggct
      361 ggcaggcgct gctgataatt agtcagaagt ccacaggagc agggcctggg gagggggtct
      421 tgaagactgt cccctgctat ggagattctg gcatcgtggc cagtatagcc agggacccct
      481 gcaccctggc ccgttctcct tcctgccctg gctctagcaa ttgagtcaca gaaatcctta
      541 atccccggtc accggcaaaa gacgacatca ggcagaaagg ggaagaaggt gccgccgccc
      601 acaccaacac cattgtcaca gaaatggaaa cgggaccgca aacagtctct ggagtcagct
      661 tatgtccccg tggtggtgga tcctcgcggg caggagccag acagtagttt caggttcaat
      721 ttctacaact cacagtattc caactctctc aatcccttct acaccctgca gaaacccacc
      781 tgtggttacc tgtaccagag agaaactgac cacacacgga aatgctttgg cattcctccc
      841 gcaaacctgg tcttgtggcg cagcacctac taaatccaag gcatctggaa gtccccaccc
      901 tgcaccttca ctctgtggtc ctgggtccca gagggaaaag tcattcattc ctggagaagc
      961 ggcgtatacc tgggctagcc aggtatgctg tgacagctga gggaggcctc ttcccaataa
     1021 acttcagtcc ttcttttttt ctggca
//
LOCUS       NM_001105945             738 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus nanos C2HC-type zinc finger 3 (Nanos3),
            transcript variant 2, mRNA.
ACCESSION   NM_001105945 XM_001072052 XM_222459
VERSION     NM_001105945.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Bhandari,D., Raisch,T., Weichenrieder,O., Jonas,S. and
            Izaurralde,E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Julaton,V.T. and Reijo Pera,R.A.
  TITLE     NANOS3 function in human germ cell development
  JOURNAL   Hum Mol Genet 20 (11), 2238-2250 (2011)
   PUBMED   21421998
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Suzuki,H., Tsuda,M., Kiso,M. and Saga,Y.
  TITLE     Nanos3 maintains the germ cell lineage in the mouse by suppressing
            both Bax-dependent and -independent apoptotic pathways
  JOURNAL   Dev Biol 318 (1), 133-142 (2008)
   PUBMED   18436203
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Lolicato,F., Marino,R., Paronetto,M.P., Pellegrini,M., Dolci,S.,
            Geremia,R. and Grimaldi,P.
  TITLE     Potential role of Nanos3 in maintaining the undifferentiated
            spermatogonia population
  JOURNAL   Dev Biol 313 (2), 725-738 (2008)
   PUBMED   18089289
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001072052.1, XM_222459.3.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..738
                     /gene="Nanos3"
                     /note="nanos C2HC-type zinc finger 3"
                     /db_xref="GeneID:288909"
                     /db_xref="RGD:1306672"
     exon            1..493
                     /gene="Nanos3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..561
                     /gene="Nanos3"
                     /note="isoform 2 is encoded by transcript variant 2; nanos
                     homolog 3"
                     /codon_start=1
                     /product="nanos homolog 3 isoform 2"
                     /protein_id="NP_001099415.1"
                     /db_xref="GeneID:288909"
                     /db_xref="RGD:1306672"
                     /translation="MGTFNLWTDYLGLARLVGALHEEEEPDVRLDPKPEPKPSSASQQ
                     ASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHA
                     HTRRFCPLTGQGYTSVYCYTTRNSAGKKLTRPDKAKTQNAGHRLGGEAAAGVYAGSKS
                     GRKPPGPSPSACCPSTTA"
     misc_feature    193..354
                     /gene="Nanos3"
                     /note="Nanos RNA binding domain; Region: zf-nanos;
                     pfam05741"
                     /db_xref="CDD:461728"
     misc_feature    193..354
                     /gene="Nanos3"
                     /note="Nanos RNA binding domain; Region: zf-nanos;
                     pfam05741"
                     /db_xref="CDD:461728"
     exon            494..738
                     /gene="Nanos3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctgctgc tcctctggcc ggccatggga acttttaatc tttggacaga ttacctaggt
       61 ctggcaagac tggttggggc tctgcatgag gaagaggagc ctgatgtcag gctggacccc
      121 aaaccagagc ccaagccaag ctcagcaagc cagcaagcca gcaaggaatc ctcagcagct
      181 ccagaacgcc tatgttcatt ctgcaaacac aatggcgagt ctcgtgcgat ctatcagtcc
      241 catgtcctga aggatgaggc agggcgggtg ctgtgtccca tcttgcgaga ttatgtgtgt
      301 ccccagtgtg gggccactca ggagcatgcc cacactcgac gcttctgccc actcaccggc
      361 cagggctata cttctgtcta ctgctacacc acccggaatt ctgcaggcaa aaagctgacc
      421 cggcctgaca aggcaaagac acagaatgct ggccaccgcc ttggaggaga agcagcagca
      481 ggtgtctatg cgggttccaa aagtggcagg aagccccctg gaccttcacc ctcggcctgc
      541 tgtccctcca ctacggccta ggagcttgga gtggggagga ccatggtggc accgttgtca
      601 ggggtctgga cacaggcatg ctggagactg gaccttgctt aggattgagg ctggccacag
      661 tcttgtcaga ggttaccttc cccaaccctg gccctgcttg tgttgttgcc tcagtgtcta
      721 ataaatgcta agaagtgg
//
LOCUS       NM_001107216            7049 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 2 (Arap2), transcript variant 1, mRNA.
ACCESSION   NM_001107216 XM_001053361 XM_223437
VERSION     NM_001107216.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7049)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223437.4, XM_001053361.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..7049
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 2"
                     /db_xref="GeneID:305367"
                     /db_xref="RGD:1306452"
     exon            1..66
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..1104
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    176..178
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="upstream in-frame stop codon"
     CDS             209..5227
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 2; centaurin, delta 1"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_001100686.1"
                     /db_xref="GeneID:305367"
                     /db_xref="RGD:1306452"
                     /translation="MSAVSEVNVDIQDFLMSINLEQYLLHFQEFGFYTVKDCTSINDN
                     VLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVYKTKNGSTPKEQHSAPSSSSNT
                     CIEFSDSVTVHRPGPAPSEMVTTNVLSEGNCHSSTSHDKLSLSSSDLPCPEEEICQNV
                     DSSQDYLFGRVNVKIDSLITQQAVEHTAGEEQTEKVNLVSEDSSKALNTNTECLPSVD
                     HPASETHCGNGTNGVLESFPPSPFFQFQGEMVVNELYVPSSPIHSPMRSRSKLVSRPS
                     RSFLLRHRPVPEIPGSTKSISGSYFRDRKSITTSAGKSLTLKDANEDNSTSIFPYGET
                     FLFQRLESSKKRSIKNEFWAHEDTVKEEAATSRNSILTKSSIYDSRKEKVSEDKVEDI
                     WIPREDKNNLPQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPL
                     SSTSENTDPSTIANAISPYACFYGSSAAKVKSGWLDKLSPQGKRMFQKRWVKFDGLSI
                     SYYNNDREMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISVLL
                     SALKSPSLTSQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKTEQDFKSGLGIT
                     IIPMNVANVKQIDRAVKQSFEIITPYRSFSFTADSEKEKQEWIEAVQQSIAETLSDYE
                     VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDA
                     SIWSNELIELFIVIGNKRANDFWAGNLKKDEEIQMDSPVDKRKIFITQKYKEGKFRKT
                     FLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHCTPYLLAKKAGQS
                     LQMEFLYHNKFSDFPQYDAHSEGGSSQEATQSTFLCDFLYQATASASRVSTEKKLLEE
                     TNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLTVHKEDFYLNTGPIFIFEIYLP
                     SERVFLFGAKTSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRK
                     GWFAMDKSSLCFCLQTQEAQEERMHLRRLQELTISTVVQNGEKVDVLLLVEKGRTLYI
                     HGYTKLDFTVWRNAIEKAAGTDGNTLQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIY
                     QKDGDPLSISELLESFKKDARSVKLRVGKHQLEDVTGVLKSFLSDIDDALLTKELYPY
                     WVSALDAQDEKQRTDKYRAFICSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLAL
                     VFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVSQAGDLLIEVFAERKEPDCSIIIRV
                     SPVMEAEELTNDILAIKNILPTKGDIWATFEVIENEELERPLHYTENVLEQVLQWSSL
                     AEPGSAYLVVKRFLTIDTIKQCREKSIKEGILKLKEEPSKILSGNKFQDRCVVLRDGH
                     LFIYKDPKSTKHEKMFPLRLMKFYLGVKKKMKPPTSWGLTACSEKHHWHLCCDSLQAQ
                     MEWMASIFIAQHENDIWPPAGKERKRSITKNPKIGGLPLIPIQHEKNATQARKNIEMA
                     RAELERLRLSERHDGDFTDSSLKDRASIIGYCLEHKDEKLRNRARKHRSFNCLEDTEA
                     EVPPGLPKGYKGLKTVKKTEDRNSKATLEPNNKLPSKVIEELSVVLQRSRSHPKELPD
                     EQTL"
     misc_feature    224..412
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="SAM domain of Arap1,2,3 (angiotensin
                     receptor-associated protein); Region: SAM_Arap1,2,3;
                     cd09490"
                     /db_xref="CDD:188889"
     misc_feature    224..412
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="SAM domain of Arap1,2,3 (angiotensin
                     receptor-associated protein); Region: SAM_Arap1,2,3;
                     cd09490"
                     /db_xref="CDD:188889"
     misc_feature    order(263..265,335..337,380..385,392..394)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="heterodimer interface EH [polypeptide binding];
                     other site"
                     /db_xref="CDD:188889"
     misc_feature    order(263..265,335..337,380..385,392..394)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="heterodimer interface EH [polypeptide binding];
                     other site"
                     /db_xref="CDD:188889"
     misc_feature    1646..1921
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 1; Region:
                     PH1_ARAP; cd13253"
                     /db_xref="CDD:270073"
     misc_feature    1646..1921
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 1; Region:
                     PH1_ARAP; cd13253"
                     /db_xref="CDD:270073"
     misc_feature    1949..2221
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 2; Region:
                     PH2_ARAP; cd13254"
                     /db_xref="CDD:270074"
     misc_feature    1949..2221
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 2; Region:
                     PH2_ARAP; cd13254"
                     /db_xref="CDD:270074"
     misc_feature    2234..2596
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGap with Rho-Gap domain, ANK repeat and PH
                     domain-containing protein 2; Region: ArfGap_ARAP2;
                     cd08856"
                     /db_xref="CDD:350081"
     misc_feature    2234..2596
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGap with Rho-Gap domain, ANK repeat and PH
                     domain-containing protein 2; Region: ArfGap_ARAP2;
                     cd08856"
                     /db_xref="CDD:350081"
     misc_feature    order(2294..2296,2303..2305,2354..2356,2363..2365,
                     2378..2380)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="arginine finger; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2294..2296,2303..2305,2354..2356,2363..2365,
                     2378..2380)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="arginine finger; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2294..2296,2303..2305,2354..2356,2363..2365)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2294..2296,2303..2305,2354..2356,2363..2365)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:350081"
     misc_feature    2870..3202
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    2870..3202
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3239..3526
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3239..3526
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3536..4075
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in ARAPs. ARAPs (also known
                     as centaurin deltas) contain, besides the RhoGAP domain,
                     an Arf GAP, ankyrin repeat ras-associating, and PH
                     domains. Since their ArfGAP activity...; Region:
                     RhoGAP_ARAP; cd04385"
                     /db_xref="CDD:239850"
     misc_feature    3536..4075
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in ARAPs. ARAPs (also known
                     as centaurin deltas) contain, besides the RhoGAP domain,
                     an Arf GAP, ankyrin repeat ras-associating, and PH
                     domains. Since their ArfGAP activity...; Region:
                     RhoGAP_ARAP; cd04385"
                     /db_xref="CDD:239850"
     misc_feature    order(3647..3649,3764..3766,3776..3778,3983..3985,
                     3992..3997,4043..4045)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239850"
     misc_feature    order(3647..3649,3764..3766,3776..3778,3983..3985,
                     3992..3997,4043..4045)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239850"
     misc_feature    3647..3649
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239850"
     misc_feature    3647..3649
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239850"
     misc_feature    4100..4393
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Ras-associating (RA) domain found in Arf-GAP with
                     Rho-GAP domain, ANK repeat and PH domain-containing
                     protein 2 (ARAP2); Region: RA_ARAP2; cd17227"
                     /db_xref="CDD:340747"
     misc_feature    4100..4393
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Ras-associating (RA) domain found in Arf-GAP with
                     Rho-GAP domain, ANK repeat and PH domain-containing
                     protein 2 (ARAP2); Region: RA_ARAP2; cd17227"
                     /db_xref="CDD:340747"
     misc_feature    4409..4744
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    4409..4744
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     exon            1105..1163
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1240
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1332
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1683
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1753
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1874
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2053
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2169
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2369
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2455
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2638
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2813
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2948
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3093
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3196
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3395
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3459
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3623
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3836
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3942
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4090
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4165
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4283
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4284..4412
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4540
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4541..4623
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4659
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4723
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4858
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..7049
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctctttct cctttagtgt gggaagcagt tctcatggga gaatcggtgt ccatctatta
       61 attgaagttt gagcacatga acagaaaata acgttctaag aacttttgtc agaagtgata
      121 gaggaaaaaa acaacccata atatacatcc ttgtgtgtgt ctcattgagc agttttaaaa
      181 atactcagat agtaatgaag ccaccattat gtccgcagtc agtgaagtaa atgtggacat
      241 ccaagatttc ctgatgagca tcaatttgga gcagtacctt ttacatttcc aggaatttgg
      301 tttttatact gtgaaggact gcacatcaat aaatgacaac gtgctacatc aaattggaat
      361 atcacctaca ggacaccgta ggaggatact taaacagttg caaatgatct tttcaaagat
      421 gcaagacttt ccaatatatg caaatgttta taagacaaag aacggcagca ccccaaaaga
      481 gcaacacagt gctccgtctt ccagcagcaa cacctgcata gagttttctg attctgttac
      541 tgtccataga cctggcccag caccatcaga gatggttaca accaatgtcc ttagtgaagg
      601 aaactgtcat tcttctacat cacatgataa gctatctctt tcttcgagtg accttccctg
      661 tccagaagaa gagatatgcc agaatgtgga ttcttcgcaa gattatttat ttggtcgtgt
      721 aaatgttaaa atagattcct tgattaccca gcaggctgtg gagcatacag ctggagaaga
      781 acaaacagaa aaagtcaatt tggtgtcaga agattctagc aaggcactta acacaaacac
      841 tgaatgtctt ccttctgtgg accatccagc atcggagaca cactgtggaa atggaactaa
      901 cggtgtatta gaaagcttcc cgccatcccc cttcttccag tttcaaggag agatggttgt
      961 gaatgaactg tatgttccat cctcaccaat ccacagcccc atgagaagcc ggagcaagtt
     1021 ggtgtccaga ccttctcgat catttctgct gagacatcgc cctgtaccag agatcccagg
     1081 gtcaacaaaa tcaatttcag ggagctattt ccgtgacaga aagagtatta ctacctcagc
     1141 tggaaaatct ttgacactga aagatgcaaa tgaggataat tcaacttcca tctttcctta
     1201 tggagagaca tttctcttcc agagactaga aagttccaag aagcgatcta taaagaatga
     1261 attttgggcc catgaggaca cagttaaaga ggaagcagcc acttcaagaa actctatcct
     1321 aaccaagtca agcatatatg atagcaggaa ggaaaaagtg agtgaagaca aagtagaaga
     1381 catttggata ccccgtgaag ataaaaataa tcttccacag gattctgctt ctgagtcaga
     1441 atactcaaca gttgaggagt gcttccagag tttaagaaga aaaaattcca aagcatctaa
     1501 gtctaggact caaaaagcct tctacttgga cccttttaat aggcacagtt atcctctaag
     1561 ttccacaagt gaaaatactg atccatcaac catcgcaaat gccatctctc cctatgcctg
     1621 cttctatggc tcttctgcag ctaaagtgaa atctggatgg ctggacaaac tctctcctca
     1681 aggaaaacgc atgtttcaga agagatgggt gaaatttgat ggccttagca tttcttacta
     1741 caataatgac agagagatgt actcaaaggg aataatcccc ctcactgcca tatccacagt
     1801 acgggcccaa ggagacaaca aatttgaaat tgttacaaca caaaggactt ttgtttttag
     1861 agtagaaaaa gaagaagaga ggaatgattg gatcagtgta ttattaagtg cactgaagtc
     1921 gccatcgctt acatcacagt tgcaagcagc cgtggcacct gagaagtgtg gatatcttga
     1981 attgagaggc tataaagcca aaatttttac tgtgttaagg ggcaacagtg tgtggctttg
     2041 caaaaccgag caggatttta agagtggact tggcattacc ataattccta tgaatgttgc
     2101 aaatgtgaag caaatagatc gagctgtgaa acagtctttt gagataatca ctccctacag
     2161 gagtttcagc ttcacagccg attcagagaa agaaaaacag gaatggattg aagctgtgca
     2221 gcagtcaata gcagaaactc tctctgatta tgaagtagct gaaaagattt ggtttaatga
     2281 atccaacagg agctgtgcag attgtaaggc cccggaccct gactgggcat ccatcaatct
     2341 ctgtgtcgtc atctgtaaga agtgcgcagg acaacataga tctttgggac caaaggactc
     2401 gaaagttaga agtctgaaaa tggatgccag tatttggagc aatgaactca tcgagctatt
     2461 tattgtcatt ggaaacaaga gagcaaatga cttttgggct ggtaacctta aaaaagatga
     2521 agaaatacag atggattcac cagtggataa gagaaaaatc tttattaccc agaaatacaa
     2581 agagggaaaa ttcagaaaga cttttttagc atctctaacc aaagaagagt taaataaggc
     2641 tctgtgtgct gcagtagtga agccagatgt gctggaaact atggctctgc tcttcagtgg
     2701 agccgatgtc atgtgtgcca caggagaccc tgtgcactgt accccctacc tgctggccaa
     2761 gaaggctggg cagagtctgc agatggaatt tctgtaccat aacaagttct cagatttccc
     2821 tcagtacgat gctcattctg agggtgggtc aagtcaggag gctacacagt ccacgttcct
     2881 ctgtgacttc ttatatcagg ccaccgcctc tgcctctaga gtctccacag agaagaagct
     2941 acttgaagag acaaataaaa aatggtgtgt attggaaggc ggcttcttga gttactatga
     3001 aaatgacagg tgtaccacac ctaatggtac cattaacatc agtgaagtta tctgcctgac
     3061 tgtccataaa gaggacttct atttgaatac tgggcccatc ttcatctttg aaatctactt
     3121 accttcagaa cgtgtctttt tgtttggagc taaaacatct cagattcaaa gaaaatggac
     3181 agagacaata gccaagcgtt ttgttccctt tgttgctgaa aacttaacag aagctgacta
     3241 tgatctgatt ggtcaactct tctacaaaga ctgccatgct ctggaccagt ggagaaaagg
     3301 ctggtttgct atggacaagt ctagcttgtg tttttgcctt caaacgcaag aagctcagga
     3361 agagaggatg cacctaagaa gactacagga actaacaatc agcacagtgg ttcaaaatgg
     3421 agaaaaagta gatgtgttac tcttggtaga aaaagggaga acactataca tccacgggta
     3481 caccaagttg gatttcacag tctggcgtaa tgcaattgaa aaagcagcag gtacagatgg
     3541 taacacatta caagatcagc agctctgcaa gaatgacgtc cccattattg tgaacagctg
     3601 catagcattt gttacacagt atggattggg atgcaaatac atttatcaaa aggatggtga
     3661 tcctttgtct ataagtgaac tcctggagag tttcaagaaa gatgcaagga gtgttaagtt
     3721 gcgagttgga aaacatcaac ttgaagatgt gacaggcgtg ctgaagagtt ttctgtctga
     3781 cattgatgat gctctcctca ccaaggagct ctatccctac tgggtctccg cattagatgc
     3841 acaagatgaa aagcaaagaa ctgacaagta cagagccttt atatgctctc ttcctggggt
     3901 caacagagca acactggcag ctctaattga acacctttac agggttcaga aatgctcaga
     3961 aatcaatcac atgaatgccc ataacttggc actggtcttt tcatcctgct tatttcaaac
     4021 taagggacaa actagtgaag aagtgaatgt aattgaagat ctaattaata attatgtgga
     4081 aatatttgag gtgtcccagg ctggagactt gttaatcgaa gtgtttgcag aaagaaagga
     4141 acctgactgt agtattataa tccgggtatc tcctgtgatg gaagcggaag agttaacgaa
     4201 tgatatatta gcaataaaaa atattcttcc tacgaaaggt gatatttggg ccacatttga
     4261 agtcattgaa aatgaagagc tagagcgtcc acttcactat acagagaatg tgttggagca
     4321 ggtgcttcag tggagttcat tagctgaacc cggttctgct tatcttgtgg tgaagaggtt
     4381 cttaaccatt gacacaatta agcagtgcag agagaaaagt atcaaggaag gcatcttaaa
     4441 actcaaagaa gaaccatcta aaatactgtc tgggaataag tttcaagacc gatgtgttgt
     4501 tttacgagat ggacatctct ttatttacaa ggatccaaag agcaccaaac atgaaaagat
     4561 gtttcctctt aggttgatga agttttatct tggtgtcaag aagaaaatga agcccccaac
     4621 cagttgggga ttgacagcct gttctgaaaa acaccactgg cacctatgtt gtgacagttt
     4681 acaagcccag atggagtgga tggccagtat ctttattgct cagcatgaaa atgatatatg
     4741 gccaccagct ggaaaggaac gaaaacgttc aataaccaaa aatcccaaga ttggaggttt
     4801 acctctgatt cctattcaac atgagaaaaa tgcaactcag gcccgtaaga atattgagat
     4861 ggcaagagca gaacttgaaa gactgcggct gagtgaaagg catgacggag actttacaga
     4921 ctccagctta aaagacagag cttccatcat aggctactgc ttggagcaca aagatgagaa
     4981 acttcgaaat cgtgccagaa aacatcgcag tttcaactgt ctggaggaca cagaggcaga
     5041 ggtcccgcct ggcctcccaa agggttataa aggtctaaag acagtgaaga agacagagga
     5101 cagaaacagc aaagccacat tagaacccaa taataagctg ccatcgaagg tcattgagga
     5161 acttagtgtg gttctccaga ggtcaagatc ccatcctaaa gagttaccag atgagcaaac
     5221 gttatagaaa gagataaaat agatcatcgc acaagttatt ttttttaaca ttgtatacac
     5281 tgtgtgcaaa acaaatcaaa ctgtaattct tgagtttcta tatctagtat gaatttgtct
     5341 gtatttaagg aatttgttta tctatactga agcactgaaa gagcatttta aaatatgtat
     5401 atatgtggtt acctgtaaga tcaactatat tttggtctgg aaacttgaaa agttcaaccg
     5461 tattaacttt ataaagtctt tgagtcactc taagtgacca gctctttgaa agtagatgtg
     5521 ttaagtgggt taatttatga tcagaaatct gtattttatt gtataaaatg ctgtgtttat
     5581 gaatcctatg aatttgtatc ataatttaca ctttgagagg cttgtaagtt aagttgtcat
     5641 gtggttttag gttaatatag ggtccatctt agggaaagaa aagggaaggt agttccaaaa
     5701 gggaaagata ctgcaatggc tgcttaacaa acattgggaa gaaaggcaag agagtaaaaa
     5761 acattccact acccatggag gtatcctaaa tcactgagga acaaaccttg ttaaggagaa
     5821 cctccttgtt aagaaaagaa tcctcagtgt cttgagtgtt tccaacaaaa atattgagct
     5881 ggcctatgtt ggtaatggca gtgactgctg tcatttatgg tgtcagtaga caggccccat
     5941 gacacactac accagagcaa ctgtctttga gtgcctgctc agaggaactt accttgcact
     6001 gaagagtgtg catgggccca gcacaggtgt tgctgtatgc agacagttct ttagggttcc
     6061 aaactgtatt tttggtacga atgaaattca tcaccatggg gtcgtttggc tttttttttt
     6121 tctttgttgc attttttttt gtttcatttc ttaatgtaac ataaaatgtt ttcttctgtg
     6181 ttatcagtgt ctactgaaag tgggcaatct ggctacttaa gcaacacatt tgcaggcagg
     6241 caggtcacgt tccaatttag ccttttctct ctacctgtgg aaatgaaata gccctgtgtt
     6301 ttggttgcca cttaataatc gggtatagat ttgataatgt tccttctgac tacattagct
     6361 tttaacagtt tatgtcaaag acagcacttt tcataaattc tttccaagtc aagtcaagtt
     6421 ggtttggcga ctcttagaac tggaaggttt tttgttgttg ttgttgttgt tgttttgtcc
     6481 tcttctgtat tttctctcct atttatgaca tgtctggtct atgagctcaa gcctttgttt
     6541 tacgtactca caggaaagca gcatgctatg aattactagg tccatctcac tcagatatgc
     6601 taaccacatg tatttgttga agatagcaga gttaactagg cgtcagtgga atctattcct
     6661 tacatccaaa taaactgtaa aggaaataaa aagtgaaact acagggcagt tgccactacg
     6721 gaggatcctt cttcaaagac agatcttgtg ttgtttggga agcaaagctt aatttttagt
     6781 aaatttgttt ctaatatgta atcatattta tatttttatt caataaagag atatatggaa
     6841 ataatgttac tggccttgtt gggtaagttt taggtgcttt ggccttacct tattagaatt
     6901 tctcctgaga gttgacctta aaatctatca catctgtttc tcttcttttc gtgagcaatt
     6961 gtctccactt ttcaaatgta acataagggc taatgatcac atcatatgta ttttgagtaa
     7021 caattaaaat agttttacaa gtccagtaa
//
LOCUS       NM_001012034            1510 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus ADP-ribosyltransferase 3 (Art3), transcript
            variant 1, mRNA.
ACCESSION   NM_001012034 XM_223235
VERSION     NM_001012034.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Shi,W., Gong,P., Fan,J., Yan,Y.H., Ni,L., Wu,X., Cui,G., Wu,X.,
            Gu,X. and Chen,J.
  TITLE     The expression pattern of ADP-ribosyltransferase 3 in rat traumatic
            brain injury
  JOURNAL   J Mol Histol 43 (1), 37-47 (2012)
   PUBMED   22037978
  REMARK    GeneRIF: ART3 may play important roles in CNS pathophysiology after
            traumatic brain injury (TBI).
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Wang,B., Golemis,E.A. and Kruh,G.D.
  TITLE     ArgBP2, a multiple Src homology 3 domain-containing,
            Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed
            cells and localized in stress fibers and cardiocyte Z-disks
  JOURNAL   J Biol Chem 272 (28), 17542-17550 (1997)
   PUBMED   9211900
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079018.1.
            
            On Feb 11, 2005 this sequence version replaced XM_223235.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1510
                     /gene="Art3"
                     /note="ADP-ribosyltransferase 3"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
     exon            1..89
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Art3"
                     /note="upstream in-frame stop codon"
     exon            90..167
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1223
                     /gene="Art3"
                     /EC_number="2.4.2.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ecto-ADP-ribosyltransferase 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform 1
                     precursor"
                     /protein_id="NP_001012034.1"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
                     /translation="MKMGHFELVTTLLAAMVLMDVFQVQAEVLDMAENVFDDEYLKCN
                     SRMEMKYIPRMHGEELANDELLQSVWDKAGIQWEAQKAQLSLPKNFKDAYGIALTAYV
                     TEAQDQSPFYHTFNRAVKIAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEESYKNV
                     VYSTSPNISFAFGEQNQARLGNFTLAYSAKPQTANEQRLLTIQTCFGVAVGKLLNKES
                     EGIVLIPLSEVFQVSRKGTDDDLILHSINSTCSYYECSFLGGLKAGSCTTNPENPDPG
                     YLNNPDLDSQKLEDSGRKSLDSVKMPEIKVLQGEENPLLPDEKPEDRNRGKANVPTPG
                     LVPVPGPKSHPSSSSGHRLLPSDTASTILLIAAAVDFIAL"
     sig_peptide     99..176
                     /gene="Art3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    183..851
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     misc_feature    183..851
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     exon            168..876
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..909
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..942
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            943..972
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1005
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1059
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1092
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1483
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgctcac tctacgtgtg tagctagctg ctgcggctgc ctgcaccgat ctgatcggct
       61 gaagaaaaga agcactttag ggaggaaaga agagaaaaat gaagatggga cattttgaat
      121 tggtcaccac gctgctggca gccatggttc taatggacgt cttccaggtg caggcggaag
      181 tgttagacat ggcagagaat gtgtttgacg acgaatattt gaagtgcaat agcagaatgg
      241 aaatgaagta tatccctcgg atgcacggtg aggagttggc aaatgacgag ctcctgcaga
      301 gtgtgtggga caaggcaggg atccagtggg aggcgcagaa ggctcagctc tccctcccta
      361 agaacttcaa ggatgcctat ggaatagctc tgacagctta cgtaaccgag gctcaggacc
      421 agagtccctt ttaccacaca ttcaaccgtg ctgtgaagat agccggcctg tcccgaagac
      481 gctacatcta taactttccg ttcaaagcgt ttcattttta cctggtaaga gccctgcagc
      541 tgctgagacg accttgtgag gagagttaca aaaacgtggt gtacagcacg agccccaaca
      601 tttcattcgc tttcggcgag caaaaccaag ccaggctggg caacttcacg ttggcgtatt
      661 cagccaaacc ccagacagct aacgagcaac ggctgctaac catccagacc tgctttggag
      721 ttgccgtggg aaagcttctt aataaagaaa gtgagggaat tgttctaatc cctctgagtg
      781 aggtttttca ggtgtcaagg aaaggaactg acgacgacct catccttcac agcataaaca
      841 gtacctgcag ctactacgag tgttcattcc tcgggggtct aaaagctggt agttgtacca
      901 caaacccaga aaatcctgac cctggatatc tcaacaaccc tgatctggac agtcagaagc
      961 tcgaagactc tggtaggaaa agccttgact ctgtgaaaat gccagaaatt aaagtgctac
     1021 aaggagagga aaatcccctc ctgccagatg aaaagcctga agacagaaat cgaggaaagg
     1081 ccaacgttcc tactccaggt ctggttccgg ttccaggtcc gaagtcccat ccttcgtcat
     1141 cctctggcca tcggctcctt ccgtcagaca cagcatccac cattttactc atcgctgctg
     1201 ctgtggactt catcgctcta tagcttggaa cgctacctta ttctctatct gaaagatgct
     1261 acggggatcc cacaggaggt ccagagaaaa aaatagtttt cctttggaca gactcactgt
     1321 gtaaaagaag aactgtatat ttgtgccttg ttctgcaagt taaaaagctg gtccagacag
     1381 tgtcatagaa ttaacttttc atttctgtat taattttagg actgcaaaaa tcccaaagct
     1441 gtatacttag attggattca ataaaaagtt taagtttact aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa
//
LOCUS       NM_001177682            2980 bp    mRNA    linear   ROD 27-MAR-2025
DEFINITION  Rattus norvegicus P2Y receptor family member 10 (P2ry10),
            transcript variant 3, mRNA.
ACCESSION   NM_001177682 XM_001059224 XM_228500
VERSION     NM_001177682.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168967.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_228500.5, XM_001059224.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168967.1, CO559392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2980
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="P2Y receptor family member 10"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
     exon            1..230
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="upstream in-frame stop codon"
     exon            231..2924
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1266
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="purinergic receptor P2Y, G-protein coupled, 10;
                     purinergic receptor P2Y10"
                     /codon_start=1
                     /product="putative P2Y purinoceptor 10"
                     /protein_id="NP_001171153.1"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
                     /translation="MGSNSTSTVESNCNAINVTFQNSLYATTYIFIFIPGLLANSAAL
                     WVLFRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKY
                     LNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAAVWIIVGTACLPFPIMRS
                     AGLANNTDSCFADLGYKQMDPLVLVTMITIAELAGFVIPVLTIACCTWKTTVSLKHPP
                     IAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKENIITSCPIVKSAMYFH
                     PFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVS"
     misc_feature    346..1194
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    346..1194
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    352..426
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    352..426
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    451..516
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    451..516
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    562..630
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    562..630
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    694..744
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    694..744
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    832..903
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    832..903
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    970..1038
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    970..1038
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1096..1173
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1096..1173
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
ORIGIN      
        1 ggacaggggc agatgtgaag gcagtgtttt gaataaaatg gtctctggct tctcagggtt
       61 ctcacagggg gaagaaatgt gattgccttt gggtctagcc agagttcaaa gtgaagtata
      121 gtgtgattag cctccactgt tacaatacac tgtaggggat gggatataac ttattgcttt
      181 ctaaaggggc tttctgtaga gctggaaagg aataatggat gccacaaaag gaaccataat
      241 tccacagttt ttcttgatga acatactgag atattcaaga tgggcagcaa tagcaccagc
      301 actgttgaga gtaattgcaa tgccattaat gtgacatttc agaactctct gtatgcaacc
      361 acctacattt tcatattcat cccgggtctc ctggctaaca gtgcagccct gtgggttctg
      421 tttcgcttca tcagcaagaa gaataaagcc atcattttca tgatcaacct ctcagtggca
      481 gaccttgctc atatcctgtc cttacctctt cggatttact attatatcaa tcgtcactgg
      541 ccattccaga gggccctttg cctgctgtgc ttctatctga aatatctcaa catgtatgcc
      601 agcatttttt tcttgacctg cattagcctt cagaggtgcc tctttcttct caagccattc
      661 agagccagaa actggaagcg gaggtacgac gtaggcatca gtgctgctgt ctggatcatt
      721 gtggggactg cctgtttgcc atttcccatc atgagaagtg ctggcttagc taataacaca
      781 gactcatgct ttgctgatct tgggtacaaa cagatggatc cattggttct ggtcaccatg
      841 attacaattg ctgaacttgc tggatttgtg attccagtgc tcacaatcgc atgttgtacc
      901 tggaaaacaa ctgtatcctt gaaacaccca ccgattgctt ttcaagggat tagtgagagg
      961 aaaaaagcat tgcggatggt tttcatgtgt gctgcagtct tcgtcatctg cttcactcct
     1021 tatcacatta acttcatttt ttacaccatg gtaaaggaaa acatcattac cagttgtccc
     1081 attgtgaaaa gtgccatgta tttccatcct ttttcactgt gccttgcaag tctctgttgt
     1141 cttttggacc cgattctgta ttatttcatg gcttcagagt ttcgtgacca actatctcgc
     1201 catgggagct ctgttactcg ttctcgtctc atgagcaggg aaagtggttc atccatggtt
     1261 agctaaaacc agataattct tcagttagga ttctctttac ctaatgttct gtggcctcgt
     1321 ccaaaggcag gaattgccag gcaaattatt tctttaactg aaccttggaa atagaagaaa
     1381 aagctttctt gtgtgatagt tgtggtctcc acagatgaag gaagcataat gtgaaaaaaa
     1441 tgtgggagta aaaataaaaa taagatccat gtgcttccaa cttacaattt atgacattct
     1501 attagttaca agtctcagat caagatcaag tttttaacag atgtttccat ccaaatataa
     1561 attgaatgca tgtatttaca tttgtcttct gtaaatagaa tagtactgag ttgccagata
     1621 tatattaatc tttacaaaaa agtaaatgtc caccatggaa taattttatt tctgaatgaa
     1681 taaaagattt caggtctttc taaaacatta aacagggaca aagtgacaca aaggttacaa
     1741 aaatgtgtga atgaatttta gcactgcatt cttgctactg aatgcagcgc atgaaaatgc
     1801 actcattgga tgtttataga tgtttattat tttctaggtt gggagtttgc tatgtatttt
     1861 tacaaagaac atctcatctt actttttcaa tacaagtgac aataaatgtg gaaattacaa
     1921 atacaaatga ataaatgtaa cagccgagag gttaaacaac atgcctcagg attaacagtt
     1981 aagtatacat ggcatatgtt tatattattg cctctgctta tatttttata ttaattaagt
     2041 caataccaag tttgagttta atgctgaaga tgcaaactga agataagcat agtaggtatg
     2101 gataatttta acacaatgtt cttgggctca tcaataaatc catatgttga ggattagcat
     2161 gatactggtt agcgtattct atgataaata tattgtccta ttagtgtaat catctgtata
     2221 gtcttgatga gaagaaactt agtagttcat tatttcaaag tcaattttat ggcttaatat
     2281 aagccatgca aatctcataa aatagaaagc tatgaaactg agccacattt tagaaaatgt
     2341 aggtttccac ttaaaaattc tccattaaaa atacttatag tatatgtaac taaataaaat
     2401 ctcaagggtt ttctgatatc agaactcaca caattgcact agaaccagag aaatattatc
     2461 acattgtgaa taaatatgag agaaatatgt gaacttattt ttttcttaaa gttacagata
     2521 atattttaag tgttcatata gatcatacaa atacaacaga ccccttagct tttcaggttg
     2581 acaattaact ggcattttat gtctgaaatt aacagagcgt agacatttgg ggtgcaggca
     2641 agaaaaggaa gtggtaggca tgcatttgtg aagactaagg aagaggaagg gaccacaaaa
     2701 ggaggaatta aaaagaacat ttgttggttt ctttgaccat gagatagttc tgtaattata
     2761 atgtaataaa gcttttttaa ttggagctat gtgtgattta ttaacttgaa tctgtaagca
     2821 ctgctttaag agagttgtta atgtgtttgg aattactggt aacattatca caataattgt
     2881 acagagcata tcactctaaa gagaaggttt ttttaaaaaa ttcaaaaaaa aaaaaaaaaa
     2941 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
LOCUS       NM_001437172            2085 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 9, mRNA.
ACCESSION   NM_001437172
VERSION     NM_001437172.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77783.1,
                                           SRR26360181.1304922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-315             JAXUCZ010000018.1  69732881-69732980
            316-462             JAXUCZ010000018.1  69735312-69735458
            463-645             JAXUCZ010000018.1  69736744-69736926
            646-801             JAXUCZ010000018.1  69740845-69741000
            802-909             JAXUCZ010000018.1  69741592-69741699
            910-2085            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2085
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            216..315
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..963
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 5 is encoded by transcript variant 9;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 5"
                     /protein_id="NP_001424101.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVS
                     SEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAA
                     FAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSE
                     EDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    373..816
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    373..816
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            316..462
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            463..645
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            646..801
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            802..909
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            910..2085
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccagtttca tggaacaaat gcagagaatc
      241 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      301 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      361 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      421 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca aggtgagaaa gtataagaaa
      481 gttatgcttg acctgctggt acacgggctg tatgatcctg tgagttccga agtcattcat
      541 gagagtgtga agacgctgac tatcatgttg ggcaagatcc agggccaacg gctgggctcc
      601 ttcttcatag acatcaccct tcagacccgg accctattgg atgatgagga tgacagcgtg
      661 cgctactcag cctttgtcct ctttgggcag ttggctgcat ttgctgggcg gaaatggaag
      721 aagttcttca cccaccaggt caaccagacc caagattccc tcctaagcca tttgcaggac
      781 gaaagccctc aggttgccaa ggcttgcaca atggctgttc aagcctgtgt tccatacctg
      841 aaacccagaa aggagcagag tttccaaagt gaagaagacc agaagaaccg caggctttcc
      901 cagcaactga gccactacca tccagagatc ctgctgttct tctatgccaa taaaatcctg
      961 taggtccaga gcagcagaga aagcccacgg gagtgccctg ccccggcatg gaatttccca
     1021 tctgtctcat aggatacctc tttgactctc gagtgattgt aagagaaaag aggatgtcag
     1081 agagcaactg aaaaaaaaat caccctggag tgcacgcaaa gtaaaattct atgcaagtgt
     1141 gtgcacatac atgcacatga ctgtggaggt cagaggacga cctcactgct gttcctaagg
     1201 cgtcatccat ctttccactg aaacaggatc tttgactggc ctggggcttg caggagctta
     1261 gactaggctt gatagctagt gagccagctc tggggttata accacagtcc atcgaaccaa
     1321 ccgtttttga ctgtgccaaa ttcaggccct tatacctact tgtgctgact aagccgtctc
     1381 cccagcccag tagatgcaca cttccttaaa acatttaaca tgcatgatgt cccaatccct
     1441 cctttctcac tccctctctg ccaggtgaca cacatttata atatgtaact tctgaggctt
     1501 gggggaacaa ttgttacctt aaacattttt aaactgtatt tgtttttgat agtttgctat
     1561 ttgctacgga ccaggagacc aaggagctgg cttacaatgt gtctttaatt tcggatgatc
     1621 ttaaaatgtc atggtcttaa aatcgtcttt aaaaagaaca acaaggaaaa gaaatattgt
     1681 tgaaaatcca ctgaatgatg ataagttaca gaataaaaac agtaacattt actgagaatg
     1741 cttacaactt atttcggtac tgtggtggtt tggatgagcg accctgcagg cttacgtatt
     1801 tgaatgcttg gtcccttctt agtggaagtg tttaggaggg gttagagggt gtgtatatca
     1861 ctggagatgg aatttgagac ttcagaagcc caagcaaggc cctgtctgtc tgtctgtctg
     1921 tctgtctgtc cgtctcttat tttgcctgcc tactgtctac agatcaagac gtaaagctct
     1981 cagttactac tctagcacca tgcctgtcta ctcctaccat gatgataatg aactggcctt
     2041 ctaaaactct aagccagccc caattaaacg cttcctttta taaga
//
LOCUS       NM_001437186            3966 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus adducin 1 (Add1), transcript variant 5, mRNA.
ACCESSION   NM_001437186 XM_063272841
VERSION     NM_001437186.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3966)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3966)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3966)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3966)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 3966)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 3966)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 3966)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 3966)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 3966)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 3966)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_063272841.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.57435.1,
                                           SRR26643289.35161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000014.1  80391692-80391851   c
            161-375             JAXUCZ010000014.1  80364782-80364996   c
            376-538             JAXUCZ010000014.1  80361344-80361506   c
            539-690             JAXUCZ010000014.1  80360265-80360416   c
            691-771             JAXUCZ010000014.1  80355305-80355385   c
            772-921             JAXUCZ010000014.1  80354818-80354967   c
            922-1065            JAXUCZ010000014.1  80352381-80352524   c
            1066-1164           JAXUCZ010000014.1  80352191-80352289   c
            1165-1341           JAXUCZ010000014.1  80351463-80351639   c
            1342-1593           JAXUCZ010000014.1  80348939-80349190   c
            1594-1638           JAXUCZ010000014.1  80348287-80348331   c
            1639-1740           JAXUCZ010000014.1  80346327-80346428   c
            1741-1830           JAXUCZ010000014.1  80345653-80345742   c
            1831-1987           JAXUCZ010000014.1  80340292-80340448   c
            1988-2086           JAXUCZ010000014.1  80337025-80337123   c
            2087-3966           JAXUCZ010000014.1  80333242-80335121   c
FEATURES             Location/Qualifiers
     source          1..3966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3966
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..160
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..375
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Add1"
                     /note="upstream in-frame stop codon"
     CDS             181..2433
                     /gene="Add1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     alpha-adducin; erythrocyte adducin subunit alpha;
                     alpha-ADD; adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 5"
                     /protein_id="NP_001424115.1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFFYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKPPNAYASCPPHGLLHWTKEDGHRTSTSAVPNLFVPLN
                     TNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQ
                     PHVIVSTTGPNPFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPN
                     TPPSTPVKLEGGLPQEPTSRDGSDATTSKPTPPDLSPDEPSEALAFPTVAEEAHASPD
                     TTQPLAEADPEPASASAPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSF
                     LKKSKKKSDS"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    1894..>2343
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    1894..>2343
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     exon            376..538
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1065
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1341
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1593
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1638
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1740
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1830
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1987
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2086
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..3966
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaggg gtgagggttg agggcgggag aggacgaggg ctgctgcagg cggcgggggt
       61 gcgcggcagc cagggggcgg agcccagcgc gagccgcagg cgaggcggcg gccgcactcg
      121 gacccgggaa gctgtgcgct tttcccgatt ctccgcggag gatcctagaa acattgtgca
      181 atgaatggtg acacgcgggc cgcagtggtg acctcaccac ctccaaccac agcccctcac
      241 aaggagaggt actttgacag agtcgatgag aacaatccag aatatttgcg ggagaggaac
      301 atggcaccag accttcgtca ggacttcaat atgatggagc agaagaagag ggtgtctatg
      361 attctgcaga gtcccgcctt ctgtgaagag ctggagtcta tgatacagga gcagtttaag
      421 aaggggaaga accctacagg cctgttggca ttacagcaga ttgcggattt catgacggcg
      481 agtgtgccca atgtctaccc ggcagctcca caaggaggaa tggccgccct gaacatgagt
      541 cttggtatgg ttactcctgt gaatgacctt agaggatctg attctattgc atatgacaag
      601 ggggagaagt tactgcgatg taagctggca gcattttaca gactagcaga cctctttggc
      661 tggtctcagc ttatctacaa tcacatcaca accagagtga actctgagca ggagcacttc
      721 ctcatcgtgc ctttcggact tctctacagt gaagtgactg cgtccagcct ggttaaggtc
      781 aatctacaag gagacatagt agaccgcgga agtactaacc tgggagtcaa ccaggccggc
      841 ttcaccttgc actcggccat ttatgctgca cgaccagatg ccaagtgcat tgtgcacatt
      901 cacacaccag caggggctgc ggtctctgca atgaagtgtg ggctcttgcc tatttccccg
      961 gaggcgcttt cccttggaga ggttgcttat catgactatc atggcattct ggttgatgaa
     1021 gaggaaaaaa ttttgattca gaagaatctg ggccctaaaa gcaaggttct cattctccgg
     1081 aatcacgggc tcgtgtcagt tggagagagt gtggaggagg ccttctttta tatccacaac
     1141 cttgtggttg catgtgagat ccaggttcga actctggcaa gtgctggagg accagacaac
     1201 ttagttctgc tggatcctgg gaagtacaaa gccaaatccc gttctccagg gactccagca
     1261 ggggaaggct ctggatcacc tcccaagtgg cagattgggg agcaggaatt tgaagctctt
     1321 atgcggatgc tcgataatct gggctacaga actggctacc cctatcgata ccctgctctg
     1381 agagagagat ctaaaaagta cagcgatgtg gaagtccctg ccagtgtcac cggccactcc
     1441 tttgctagtg acggcgattc gggcacttgc tcgccgctca gacacagttt tcagaagcag
     1501 cagcgagaga agacaagatg gctgaactct ggccggggtg atgacgcttc tgaggagggg
     1561 cagaacggaa gcagtcccaa gtcgaagact aagcctccga atgcttatgc cagctgccct
     1621 ccgcatggac tgttgcattg gactaaagag gatggacata gaacttccac ctctgctgtc
     1681 cctaacctgt ttgttccatt gaacactaac ccaaaagagg tccaggagat gaggaacaag
     1741 attcgagagc agaacttaca ggacattaag acggcaggac ctcagtcgca ggttttgtgt
     1801 ggtgtgatga tggacagaag ccttgtccag ggggagctcg tgacggcctc caaagccatc
     1861 attgagaagg aataccagcc tcatgtaatt gtgagcacca caggtcccaa ccccttcaac
     1921 acgctcacag accgtgaact agaggaatac cgccgagagg tggagcggaa gcagaagggc
     1981 tctgaagaga acctggacga gacaagagag cagaaagaga agagtcctcc agaccagtca
     2041 gctgttccca acactccgcc cagcactccc gtcaagcttg aaggaggcct tccccaggag
     2101 ccgacatcca gggatggcag cgatgccacc acctccaagc cgactccccc tgacctctcc
     2161 cctgatgagc cttcagaagc acttgccttc ccaacagtgg cagaggaagc ccatgcttcc
     2221 ccagacacca ctcagcccct tgctgaggct gaccctgagc cagcctcagc ctcagctcca
     2281 ggagctgaag aggtagcctc ccctgccact gaggaggggt ctcccatgga ccctggcagc
     2341 gatgggtctc caggcaagtc cccatccaag aagaagaaga agttccgcac cccgtccttc
     2401 ctgaagaaga gcaagaagaa gagtgactcc tgaaggccca ccctgcatac tgtcgtgtct
     2461 gaaggcctgg ctctgccagg actccctcct ctgtcttgtg ttctgtcctc tcgtgtaatg
     2521 gaatgcaaaa agccaagacc tccatgtaac tagagccccc tcccatgtat ggtcagcccc
     2581 tgcaccagtg ctaacccagt gtgtgctcag cccctctacc ctgggccttg ggttctgtgg
     2641 ggagttgggc ttagcctgca cctgtgagtt gtgcccccct gcaggagggg gacactgaat
     2701 cctggtcctg gctggaaggc ataggaggct tctgccagct ctggttacag cgtcaccctc
     2761 ctgagccttg cctctcactc tcctttctgt cgtgagtatt gaattgtctg ctcagtttcc
     2821 ctccaccctg tggagtctca ggtggctgat ttggactcgg ctttgctggc atcctctgct
     2881 ccgtgatgtc agttatcccc atacacaggt atccacatac cccagccatg gtctgagaaa
     2941 acactctcat gtccatccgc ggcccacact gtggctgcct taaagacatg ggttaagtct
     3001 gctgccctag cagtgagcaa ccctttgtat acccagcaca acgctatgca tggtctaact
     3061 gatgacccca tgaccaaaac cacattcagg cgctcatagt tgaccttacc ggggtcttgc
     3121 attcccatct tagggaacag ataccaggag ggggaagagt cctttctaaa actttgtttc
     3181 agcaggtttg cgatttagcc tccattttta ctgtgaactt gaacaggcca ctttttgcgt
     3241 tagtttttgt tgtagagcct atgacagact gcagcagaac actcttgact tgtgtgggga
     3301 ggttttgtag gaacagggac cataactcag tctgaacgat gccctggttt tgatagggat
     3361 ggtaactcat ggttgaagct ggctttggag gtgccatcta atgtcttgca tcattcatgg
     3421 agcccatgac cttcttggtc atcccttatg aatttttacc taacttttat ccctggaaaa
     3481 gggcttgaaa ctgctttagt gagtggggaa gccgagtgtc aggtggaatc ctaaggggcc
     3541 ttgttccagg agctgccact gccagcctga ctaggagagg gagcctgctg gggccctcca
     3601 cgcccctgct gggttgggcc tcatagagcg ggtgctcgga tgtggacaga accctgtgat
     3661 ctcccaatgg ggcaccaagc aggaccccac agcctgctgt actgctagtc ccactagtca
     3721 ccacggtggc ctgagctctc acctggtcct gagtcccctc atctggactc ctcctcgtct
     3781 tccttctggc ccttccttta tcccacatat gcaatgactt ctcacttttg tagtctaatc
     3841 tttgtattac acacggaata tcgctgcata tatggacaga cttggaggac aggtcctgtg
     3901 tgtcctttcc tcgtcgtaac aggtcttact cacaaataaa agtctttaag cagtttcttt
     3961 gtctaa
//
LOCUS       NM_001437170            2119 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 7, mRNA.
ACCESSION   NM_001437170
VERSION     NM_001437170.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.607854.1,
                                           SRR26360194.372641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000018.1  69725889-69725982
            95-246              JAXUCZ010000018.1  69726124-69726275
            247-346             JAXUCZ010000018.1  69732881-69732980
            347-493             JAXUCZ010000018.1  69735312-69735458
            494-679             JAXUCZ010000018.1  69736741-69736926
            680-835             JAXUCZ010000018.1  69740845-69741000
            836-943             JAXUCZ010000018.1  69741592-69741699
            944-2119            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2119
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..94
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            95..246
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    125..127
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            247..346
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..997
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 4 is encoded by transcript variant 7;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 4"
                     /protein_id="NP_001424099.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPV
                     SSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLA
                     AFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQS
                     EEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    404..850
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    404..850
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            347..493
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            494..679
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            680..835
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            836..943
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            944..2119
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtaagg aaaccagggc tgggaaaatc
      121 tcgctgactc accacatttg gaggccaatc ccgaatcggt ggaacaacgc gcctcccgag
      181 agacccagga ctagcctcca gccccgaaac agcggttctt cacgtgacag tcaccccagg
      241 agccagtttc atggaacaaa tgcagagaat cccgaaccag cccctcccca cccctgcttc
      301 tcagtccaag aagaggagga caccactgtc atctttcttt tccaaggtct cttggaaact
      361 gaggttgcag aagcgggaac ctttgaagaa tctgtttttc gtcttggcag aaagagcccg
      421 gggtcctaat cctagaaagc gccatctagc aatgagaggc ctgggtatct tggcccatga
      481 agctcctgac aagcaggtga gaaagtataa gaaagttatg cttgacctgc tggtacacgg
      541 gctgtatgat cctgtgagtt ccgaagtcat tcatgagagt gtgaagacgc tgactatcat
      601 gttgggcaag atccagggcc aacggctggg ctccttcttc atagacatca cccttcagac
      661 ccggacccta ttggatgatg aggatgacag cgtgcgctac tcagcctttg tcctctttgg
      721 gcagttggct gcatttgctg ggcggaaatg gaagaagttc ttcacccacc aggtcaacca
      781 gacccaagat tccctcctaa gccatttgca ggacgaaagc cctcaggttg ccaaggcttg
      841 cacaatggct gttcaagcct gtgttccata cctgaaaccc agaaaggagc agagtttcca
      901 aagtgaagaa gaccagaaga accgcaggct ttcccagcaa ctgagccact accatccaga
      961 gatcctgctg ttcttctatg ccaataaaat cctgtaggtc cagagcagca gagaaagccc
     1021 acgggagtgc cctgccccgg catggaattt cccatctgtc tcataggata cctctttgac
     1081 tctcgagtga ttgtaagaga aaagaggatg tcagagagca actgaaaaaa aaatcaccct
     1141 ggagtgcacg caaagtaaaa ttctatgcaa gtgtgtgcac atacatgcac atgactgtgg
     1201 aggtcagagg acgacctcac tgctgttcct aaggcgtcat ccatctttcc actgaaacag
     1261 gatctttgac tggcctgggg cttgcaggag cttagactag gcttgatagc tagtgagcca
     1321 gctctggggt tataaccaca gtccatcgaa ccaaccgttt ttgactgtgc caaattcagg
     1381 cccttatacc tacttgtgct gactaagccg tctccccagc ccagtagatg cacacttcct
     1441 taaaacattt aacatgcatg atgtcccaat ccctcctttc tcactccctc tctgccaggt
     1501 gacacacatt tataatatgt aacttctgag gcttggggga acaattgtta ccttaaacat
     1561 ttttaaactg tatttgtttt tgatagtttg ctatttgcta cggaccagga gaccaaggag
     1621 ctggcttaca atgtgtcttt aatttcggat gatcttaaaa tgtcatggtc ttaaaatcgt
     1681 ctttaaaaag aacaacaagg aaaagaaata ttgttgaaaa tccactgaat gatgataagt
     1741 tacagaataa aaacagtaac atttactgag aatgcttaca acttatttcg gtactgtggt
     1801 ggtttggatg agcgaccctg caggcttacg tatttgaatg cttggtccct tcttagtgga
     1861 agtgtttagg aggggttaga gggtgtgtat atcactggag atggaatttg agacttcaga
     1921 agcccaagca aggccctgtc tgtctgtctg tctgtctgtc tgtccgtctc ttattttgcc
     1981 tgcctactgt ctacagatca agacgtaaag ctctcagtta ctactctagc accatgcctg
     2041 tctactccta ccatgatgat aatgaactgg ccttctaaaa ctctaagcca gccccaatta
     2101 aacgcttcct tttataaga
//
LOCUS       NM_001437169            2088 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 6, mRNA.
ACCESSION   NM_001437169
VERSION     NM_001437169.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2734115.1,
                                           SRR26643429.54677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-315             JAXUCZ010000018.1  69732881-69732980
            316-462             JAXUCZ010000018.1  69735312-69735458
            463-648             JAXUCZ010000018.1  69736741-69736926
            649-804             JAXUCZ010000018.1  69740845-69741000
            805-912             JAXUCZ010000018.1  69741592-69741699
            913-2088            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2088
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            216..315
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..966
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 4 is encoded by transcript variant 6;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 4"
                     /protein_id="NP_001424098.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPV
                     SSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLA
                     AFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQS
                     EEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    373..819
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    373..819
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            316..462
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            463..648
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            649..804
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            805..912
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            913..2088
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccagtttca tggaacaaat gcagagaatc
      241 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      301 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      361 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      421 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca agcaggtgag aaagtataag
      481 aaagttatgc ttgacctgct ggtacacggg ctgtatgatc ctgtgagttc cgaagtcatt
      541 catgagagtg tgaagacgct gactatcatg ttgggcaaga tccagggcca acggctgggc
      601 tccttcttca tagacatcac ccttcagacc cggaccctat tggatgatga ggatgacagc
      661 gtgcgctact cagcctttgt cctctttggg cagttggctg catttgctgg gcggaaatgg
      721 aagaagttct tcacccacca ggtcaaccag acccaagatt ccctcctaag ccatttgcag
      781 gacgaaagcc ctcaggttgc caaggcttgc acaatggctg ttcaagcctg tgttccatac
      841 ctgaaaccca gaaaggagca gagtttccaa agtgaagaag accagaagaa ccgcaggctt
      901 tcccagcaac tgagccacta ccatccagag atcctgctgt tcttctatgc caataaaatc
      961 ctgtaggtcc agagcagcag agaaagccca cgggagtgcc ctgccccggc atggaatttc
     1021 ccatctgtct cataggatac ctctttgact ctcgagtgat tgtaagagaa aagaggatgt
     1081 cagagagcaa ctgaaaaaaa aatcaccctg gagtgcacgc aaagtaaaat tctatgcaag
     1141 tgtgtgcaca tacatgcaca tgactgtgga ggtcagagga cgacctcact gctgttccta
     1201 aggcgtcatc catctttcca ctgaaacagg atctttgact ggcctggggc ttgcaggagc
     1261 ttagactagg cttgatagct agtgagccag ctctggggtt ataaccacag tccatcgaac
     1321 caaccgtttt tgactgtgcc aaattcaggc ccttatacct acttgtgctg actaagccgt
     1381 ctccccagcc cagtagatgc acacttcctt aaaacattta acatgcatga tgtcccaatc
     1441 cctcctttct cactccctct ctgccaggtg acacacattt ataatatgta acttctgagg
     1501 cttgggggaa caattgttac cttaaacatt tttaaactgt atttgttttt gatagtttgc
     1561 tatttgctac ggaccaggag accaaggagc tggcttacaa tgtgtcttta atttcggatg
     1621 atcttaaaat gtcatggtct taaaatcgtc tttaaaaaga acaacaagga aaagaaatat
     1681 tgttgaaaat ccactgaatg atgataagtt acagaataaa aacagtaaca tttactgaga
     1741 atgcttacaa cttatttcgg tactgtggtg gtttggatga gcgaccctgc aggcttacgt
     1801 atttgaatgc ttggtccctt cttagtggaa gtgtttagga ggggttagag ggtgtgtata
     1861 tcactggaga tggaatttga gacttcagaa gcccaagcaa ggccctgtct gtctgtctgt
     1921 ctgtctgtct gtccgtctct tattttgcct gcctactgtc tacagatcaa gacgtaaagc
     1981 tctcagttac tactctagca ccatgcctgt ctactcctac catgatgata atgaactggc
     2041 cttctaaaac tctaagccag ccccaattaa acgcttcctt ttataaga
//
LOCUS       NM_001437202            3293 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 2, mRNA.
ACCESSION   NM_001437202 XM_006250805
VERSION     NM_001437202.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3293)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3293)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3293)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3293)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3293)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3293)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3293)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3293)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250805.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.56327.1,
                                           SRR26643290.44123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-351             JAXUCZ010000014.1  21565940-21565975   c
            352-453             JAXUCZ010000014.1  21560488-21560589   c
            454-782             JAXUCZ010000014.1  21559484-21559812   c
            783-1215            JAXUCZ010000014.1  21558937-21559369   c
            1216-1305           JAXUCZ010000014.1  21556341-21556430   c
            1306-1359           JAXUCZ010000014.1  21555834-21555887   c
            1360-1454           JAXUCZ010000014.1  21555171-21555265   c
            1455-1563           JAXUCZ010000014.1  21553803-21553911   c
            1564-1681           JAXUCZ010000014.1  21553603-21553720   c
            1682-1766           JAXUCZ010000014.1  21550070-21550154   c
            1767-1933           JAXUCZ010000014.1  21548930-21549096   c
            1934-2016           JAXUCZ010000014.1  21546400-21546482   c
            2017-2053           JAXUCZ010000014.1  21545168-21545204   c
            2054-2117           JAXUCZ010000014.1  21545032-21545095   c
            2118-2180           JAXUCZ010000014.1  21544877-21544939   c
            2181-2315           JAXUCZ010000014.1  21543336-21543470   c
            2316-3293           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3293
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2540
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 2 is encoded by transcript variant 2; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 2"
                     /protein_id="NP_001424131.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKEDCQDCSSWLFSDGELNVLDDILTEVPEQDDELYN
                     PESEQDKNEKKGSKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGK
                     SVTEYKNEEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPT
                     PDGSERIGLEVDRRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEE
                     DVEEDEEVDEDGDDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEG
                     NDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSA
                     SESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVW
                     STLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMS
                     AKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFP
                     PDESIDLYQLIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRI
                     DYPPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGP
                     PPPWQGMPPYPGIEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMR
                     VDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDR
                     DRGERGRYRR"
     misc_feature    426..428
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    675..677
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    681..683
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    759..761
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    765..767
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1254..1256
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1275..1277
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1281..1283
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1284..1286
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1290..1292
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1398..1808
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1398..1808
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1602..1604
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1635..1637
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1857..2021
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1965..1967
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    2175..2285
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2361..2537
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            316..351
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            352..453
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            454..782
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1215
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1305
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1359
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1454
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1563
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1681
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1766
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1933
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2016
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2053
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2117
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2180
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..3293
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagaagat tgccaagact gctccagctg gttgttttca gatggggaac
      361 ttaatgtttt agatgatatt ttgactgaag taccagaaca ggatgatgaa ctgtataatc
      421 cagagagtga acaagataaa aatgagaaaa aaggatcaaa aagaaaaagt gaaagaatgg
      481 aatctattga caccaagcga cagaagcctt ctatccattc aagacaactg atttctaagc
      541 cactaagctc atctgttagc aataataaaa gaatagttag tacaaaagga aagtcggtta
      601 cagaatataa aaatgaggaa tatcaaagat ctgaaaggaa caagcgtcta gatgctgatc
      661 gaaaaattcg tctgtcaagc agttcctcta gagaacctta caagagtcaa ccagaaaaac
      721 cttgtctacg gaaaagggat tctgaaagaa gggccaagtc tcctacacca gatggttctg
      781 agagaattgg gcttgaagtt gatagacgtg caagcagatc cagccagtct tcaaaggaag
      841 aggggaactc tgaggagtat ggctctgacc acgagacagg aagcagtgct tcttctgaac
      901 agggcaacaa cactgagaat gaggaggaag gaggggaaga agatgtagag gaagatgaag
      961 aggtagatga agatggagat gatgatgagg aagtggatga agatgcggag gaggaggagg
     1021 acgaggaaga agatgaggag gaggaggatg aggaagaaga agaggaagag gaagaagaat
     1081 atgaacagga tgagagagat cagaaggaag aagggaatga ttatgacacc cgtagtgagg
     1141 ccagtgattc tggttctgag tctgtttcct tcacagatgg atctgtcagg tctggttcag
     1201 gaacagatgg atcagatgag aaaaagaagg aaaggaagag agctcgaggc atatcaccca
     1261 ttgtctttga tagaagtggc agttctgcat cagagtcata tgcaggttca gaaaagaagc
     1321 atgagaaatt atcatcttcc gttcgtgctg tccgaaaaga tcaaaccagt aaactcaaat
     1381 atgtccttca ggatgcaaga tttttcctca taaagagtaa caaccatgag aatgtgtctc
     1441 ttgccaaagc aaagggtgta tggtccacat tacctgtaaa tgagaagaaa ttaaatcttg
     1501 cgtttagatc tgcaaggagt gttatattaa tattttctgt cagggaaagt ggaaagtttc
     1561 aaggttttgc cagattgtca tcagaatcgc atcatggtgg ctctcctata cattgggtgc
     1621 ttccagcagg aatgagtgct aaaatgcttg gaggtgtttt taaaattgac tggatttgca
     1681 ggcgtgaatt accctttact aagtcagctc atctcaccaa tccctggaat gaacataagc
     1741 cagtaaagat tggacgtgat ggacaggaaa ttgaacttga atgtggaacc cagctttgtc
     1801 ttctgtttcc ccctgatgaa agtattgact tgtatcagct cattcataaa atgcgtcaca
     1861 agagaagaat gcattctcag cctcgatcaa gaggacgtcc atcccgtcga gaaccagtcc
     1921 gggatgtggg aaggcgtcga ccagaagatt atgatattca taacagcaga aagaaaccaa
     1981 ggattgacta tccccctgag tttcaccaga gaccagggta tttaaaggat ccccgatacc
     2041 aggaagttga cagtttcaca aatcttattc ccaacagacg attttcagga gttcgccgag
     2101 atgtgttttt aaatgggtcc tacaatgatt atgtgaggga atttcataac atgggaccac
     2161 cgcctccttg gcaaggaatg cctccttacc cgggaataga acagcctcca caccatccct
     2221 actaccagca ccatgccccg cctcctcaag cccacccccc ttactcagga caccatccgg
     2281 taccacatga agcaagatac agagataaac gagtacatga ctatgatatg agggttgatg
     2341 atttccttcg ccgcacacaa gccgttgtca gtggtcggag aagtagaccc cgagaaagag
     2401 atcgggagcg agagcgagac cgccctagag ataacagaag agatagagag cgagacagag
     2461 gtcgtgatcg agaaagagag agagaaagaa tatgtgatcg ggacagagac cgaggggaaa
     2521 gaggtcgtta tcgaagataa tgtgcttttt ggaagcactg actgaagata aaaaatattg
     2581 tatttttttt gtgtgtgttt acaagtagta aatttatttt cagctgtcta cttaaagctc
     2641 attgtgtaga aggatttatt atcttctttg ttccaagcat gcagtagaat aagaactgga
     2701 aaactcagat ccgccaaaaa atgcacagtt gacagttgag ttgacacttt tattggggca
     2761 gaatggaaca gtccaagaat gtagatattg attcattctc cataaatgtt ctttttacag
     2821 tgtattcatc ctagagttat tttgtttgtt tgttttcctt cttttggacc ttggtcaata
     2881 ctgccatagt attttgcttt gtgtttctat aggtagctgc acacggttca gtaaaaataa
     2941 tgctgctatc aagtatgcag atattgagta tgatggtttg actatatggc agtgttgtag
     3001 cagcctctcg gtttctcctc ttccctcctt ttttttaaac ctataaatcc actttttttt
     3061 taagtcttca atgatgagag caatattaag aagacattgc tatctaattt ttaatctttt
     3121 taaataaaac gttcctatgt tcagtagcat ggtcgatgct attgtttagc cttccttcca
     3181 aactgtacat tggcttggaa tgttcagttt tgcgtgtgtg gcagcagaag ataaccccac
     3241 attctacatt gctactgttt tgtatgaaat aaattggtaa agattgacac taa
//
LOCUS       NM_001437211            4746 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 2, mRNA.
ACCESSION   NM_001437211 XM_006250882
VERSION     NM_001437211.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4746)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4746)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4746)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4746)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4746)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4746)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4746)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4746)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250882.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.465503.1,
                                           SRR26643290.44223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-904             JAXUCZ010000014.1  34017713-34017781   c
            905-1014            JAXUCZ010000014.1  34009985-34010094   c
            1015-1122           JAXUCZ010000014.1  34002247-34002354   c
            1123-1216           JAXUCZ010000014.1  33995782-33995875   c
            1217-1373           JAXUCZ010000014.1  33994406-33994562   c
            1374-1400           JAXUCZ010000014.1  33983462-33983488   c
            1401-1455           JAXUCZ010000014.1  33981524-33981578   c
            1456-1511           JAXUCZ010000014.1  33980419-33980474   c
            1512-1731           JAXUCZ010000014.1  33976291-33976510   c
            1732-1869           JAXUCZ010000014.1  33972832-33972969   c
            1870-4746           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4746
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..2017
                     /gene="Fip1l1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     2"
                     /protein_id="NP_001424140.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTME
                     VTPGAEIQDGRFNLFKVQQGRTGNSEKEAALPSTKAEFTSPPSLFKTGLPPSRNSTSS
                     QSQTSTASRKASSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANEN
                     SNIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGI
                     PITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWP
                     SLVDTTKQWDYYARREKDRDRDRERDRDRERERDRDRERERTRERERERDHSPTPSVF
                     NSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEE
                     GDSHRRHKHKKSKRSKEGKEAGSEPVPEQESTEAAPAE"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..904
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1014
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1122
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1216
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1373
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1400
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1455
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1511
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1731
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1869
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..4746
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggccga
      841 agactgtact atggaagtca caccaggtgc agagatccaa gatggcagat tcaatctttt
      901 taaggtacag caagggagaa ctggaaattc agagaaagaa gcagcacttc catctacaaa
      961 agctgagttt acttctccgc catcattgtt caagactggt ctgccaccaa gcagaaacag
     1021 cacctcttct cagtctcaga caagtactgc ctccagaaaa gccagttcaa gcgttgggaa
     1081 gtggcaggat cgatatggga gggccgagtc acctgatcta aggagattac ctggagcaat
     1141 cgatgtcatt ggtcaaacaa taaccatcag ccgagtagaa ggaagacggc gtgcaaatga
     1201 gaacagcaat atacaggttc tttctgacag atctgccact gaagtagaca acaatttcag
     1261 caaaccacct ccatttttcc ctccaggggc tcctcctact caccttcctc ctcctccatt
     1321 tcttccacct cctccaactg tcagcactgc tccacctttg attccaccac caggtattcc
     1381 aataactgta ccacctccag gtttcccccc tccaccaggc gctccacctc catctcttat
     1441 accgacaata gaaagtggcc attcctctgg ttacgacagc cgttctgcac gggcgtttcc
     1501 atatggcaat gttgcctttc cccaccttac cagttccgct ccctcatggc ctagccttgt
     1561 ggataccact aagcagtggg actattatgc acggagagaa aaagatcgag atcgagaccg
     1621 agagagagac cgagacagag aaagggagag agaccgggac agagaaaggg agcgcacccg
     1681 ggagcgagag cgggagcggg accacagccc caccccaagt gttttcaaca gtgatgaaga
     1741 gcgatacaga tacagggagt atgcagagag aggctatgag cgccacagag ctagtcggga
     1801 gaaagaagag cggcacagag aacgacggca cagagagaag gaggaaacaa gacacaagtc
     1861 ctctcgcagt aatagtagac gtcgtcatga aagtgaagaa ggggacagtc acagaagaca
     1921 caagcacaaa aagtctaaaa ggagcaaaga aggaaaagag gctggcagcg agccggtccc
     1981 tgagcaggag agcacggaag ctgcccctgc cgagtaggcg ccacctctta tgtacgtcag
     2041 ccccagaaat agatgctata aatctcctta tttttctgga taatgtttaa gaaatgtacc
     2101 tttaatcttg ttctgttaga atgaaacgtt aactttttct tttccaaaat aaaagtgtgc
     2161 atttttttgt gttaagttaa aaatctttgt cttgtaatat ttaaagaata aaagacaaaa
     2221 attactttat atctaagaaa gtaatgtgaa taagtcagca ggggacttag tgctaagttg
     2281 gccgtgtgtg cagtgtggtg aggatcaagg actcactagc tttctagtga gcgggacgct
     2341 gtcggcagga gaggtgctgt ggtgcagaag cccctctcat gtgacgtcag gcttcctctt
     2401 actgctgtca cactcctgca tctttaagaa cttggacaca ttcttgttat cacagttttg
     2461 atagcaggtt ttcagtggtc catagtaact aaatggactg tttgaatctc tgactttaga
     2521 gatggtctga ggcacttggg tggccctatg atggaacttg tgtgcttccc agcaggcaca
     2581 tggactggca cagcgtcaaa ccacttcatg gccatctgtt tgaacaaggg tcaagggctt
     2641 cagctgctgc taacgtgttt tccaaggctc attggtagca tagaacgtgg ggtatttttt
     2701 gtaataccag gtccatatta ataaaaaata aactcagtga gagtagtgtc agatcagtca
     2761 ttcttactaa aaccagaact ccaggttaaa atctggacta accccaagaa ggttccagag
     2821 cagcggtggg gctgggaatg tgtgtgaaag gacgaggcag ttagagccac cagtaagagg
     2881 actgcggtca cttagaagaa gatattcatc tcttgttcaa atcctccgcc attaaactga
     2941 aatggccata atgtgctgtg tcttcaactc cacttctacc acatttgacg ttgccttgaa
     3001 ttaagtgtgg catacaaacc atgtaagttt ttatgggctt tttattgaat taaaaaaata
     3061 gaaacttaaa agatttggag tgatgagaaa tcctccacac caaataaaaa ttaacattag
     3121 tttttatttt tgagaacatt ctctgatgtg taacttgttt tcataagtca tactttttct
     3181 ggcttttttt ttttacaata tattctttaa atataaaaat cgacaagata aatacaattt
     3241 tatctagcct atttgtggtt tttctaagat ccatcattgg ttttataaaa aagtaccagg
     3301 ccaggaagca atggtgagag taattttccc tttgagttct ttgagcatcc tcgctaagca
     3361 ggcgtgcatc atccccgacg tgcttctgcc gttgacagca agaagaatgt caccacatct
     3421 gaaaagatac ggcattgtga tcagaactgc ttcaagcctg aagcgcctca aagtggactt
     3481 gggtggccct agggctgcca tatttgtcct ttttagttct gatttgattt ccctcttccc
     3541 ataaattctc caagctccac gcagcgtgca tcaaaggtat aggaaattgc aaggtgggac
     3601 caaggccggt tctagttttg gatttctctc tacctagcta gtgctctcgt gtcttaattt
     3661 ctcactcttt aggaaagtat aagctgcgct ttcttccaag tggggccaag ttttacatgt
     3721 agaaagcaaa atacttgaat attagttttc tgagtaatca ttacctaatt cttccatcat
     3781 tatacgcggg tgttccctcg acgatggatt tgataaaaaa aggttggtta ccactgtatt
     3841 cttcataacc tcccacaatg cagaagccca ggcttcccgc tgtgttcctt cgtagtatca
     3901 catccttaca gttatataag tacctgaaac agaatgtaat tagtggatgt acagttgagt
     3961 ttactagttg tgactccttt cattcatttt tttgggggac acttttaaaa tgaaaaatac
     4021 tgcatatgtc tccatcagaa gtgacagcaa ctttttatgc tcttagtcag cttttgcatt
     4081 tgatctctct tttccatagc caaataccct ttcaacaaaa ggagttagta ttatgttcta
     4141 ttcatgtctc tgctgagaaa aatggccaca tattttggtt aaggcgcagt aatgaatgca
     4201 tgagccaaaa gttggatgtg tctcagtact tcttattccc cacagtagaa catactgagg
     4261 gaatatcatt tttatattct tgggggctta cataatttgt aaagaagaca aacattctct
     4321 gaattagcga ttaatcgcaa ggacaataat tttaacttat gctaatgaac ttatactcac
     4381 acagacttag agaagactag agaaagtgaa tggaaattgg gccataaaat agtggagcag
     4441 ttgtcggaca gtaagtggca tagctgaagc agtcagggga agggaaggag cacagctggc
     4501 ctgagagcca gtacagcctt cagctgggat agccgcggct aagtgtgagc agctgcacta
     4561 cagtagactg tcggaagatg gggtcgctct gggacccctt gtctgccgca tgtgtctagg
     4621 aactgctttt gactggaaga tagtattttt tgttgttaga attgaagatg tcttgtttat
     4681 agactgtacc ttaaaataat cagttgcttt ttgataatca ataaaaatga tcttgtgaaa
     4741 tattaa
//
LOCUS       NM_001437174            2257 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 11, mRNA.
ACCESSION   NM_001437174
VERSION     NM_001437174.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35236.1,
                                           SRR26643293.77786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-487             JAXUCZ010000018.1  69732881-69732980
            488-634             JAXUCZ010000018.1  69735312-69735458
            635-817             JAXUCZ010000018.1  69736744-69736926
            818-973             JAXUCZ010000018.1  69740845-69741000
            974-1081            JAXUCZ010000018.1  69741592-69741699
            1082-2257           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2257
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            388..487
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1135
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 5 is encoded by transcript variant 11;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 5"
                     /protein_id="NP_001424103.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVS
                     SEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAA
                     FAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSE
                     EDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    545..988
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    545..988
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            488..634
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            635..817
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            818..973
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1081
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..2257
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagttt catggaacaa atgcagagaa tcccgaacca
      421 gcccctcccc acccctgctt ctcagtccaa gaagaggagg acaccactgt catctttctt
      481 ttccaaggtc tcttggaaac tgaggttgca gaagcgggaa cctttgaaga atctgttttt
      541 cgtcttggca gaaagagccc ggggtcctaa tcctagaaag cgccatctag caatgagagg
      601 cctgggtatc ttggcccatg aagctcctga caaggtgaga aagtataaga aagttatgct
      661 tgacctgctg gtacacgggc tgtatgatcc tgtgagttcc gaagtcattc atgagagtgt
      721 gaagacgctg actatcatgt tgggcaagat ccagggccaa cggctgggct ccttcttcat
      781 agacatcacc cttcagaccc ggaccctatt ggatgatgag gatgacagcg tgcgctactc
      841 agcctttgtc ctctttgggc agttggctgc atttgctggg cggaaatgga agaagttctt
      901 cacccaccag gtcaaccaga cccaagattc cctcctaagc catttgcagg acgaaagccc
      961 tcaggttgcc aaggcttgca caatggctgt tcaagcctgt gttccatacc tgaaacccag
     1021 aaaggagcag agtttccaaa gtgaagaaga ccagaagaac cgcaggcttt cccagcaact
     1081 gagccactac catccagaga tcctgctgtt cttctatgcc aataaaatcc tgtaggtcca
     1141 gagcagcaga gaaagcccac gggagtgccc tgccccggca tggaatttcc catctgtctc
     1201 ataggatacc tctttgactc tcgagtgatt gtaagagaaa agaggatgtc agagagcaac
     1261 tgaaaaaaaa atcaccctgg agtgcacgca aagtaaaatt ctatgcaagt gtgtgcacat
     1321 acatgcacat gactgtggag gtcagaggac gacctcactg ctgttcctaa ggcgtcatcc
     1381 atctttccac tgaaacagga tctttgactg gcctggggct tgcaggagct tagactaggc
     1441 ttgatagcta gtgagccagc tctggggtta taaccacagt ccatcgaacc aaccgttttt
     1501 gactgtgcca aattcaggcc cttataccta cttgtgctga ctaagccgtc tccccagccc
     1561 agtagatgca cacttcctta aaacatttaa catgcatgat gtcccaatcc ctcctttctc
     1621 actccctctc tgccaggtga cacacattta taatatgtaa cttctgaggc ttgggggaac
     1681 aattgttacc ttaaacattt ttaaactgta tttgtttttg atagtttgct atttgctacg
     1741 gaccaggaga ccaaggagct ggcttacaat gtgtctttaa tttcggatga tcttaaaatg
     1801 tcatggtctt aaaatcgtct ttaaaaagaa caacaaggaa aagaaatatt gttgaaaatc
     1861 cactgaatga tgataagtta cagaataaaa acagtaacat ttactgagaa tgcttacaac
     1921 ttatttcggt actgtggtgg tttggatgag cgaccctgca ggcttacgta tttgaatgct
     1981 tggtcccttc ttagtggaag tgtttaggag gggttagagg gtgtgtatat cactggagat
     2041 ggaatttgag acttcagaag cccaagcaag gccctgtctg tctgtctgtc tgtctgtctg
     2101 tccgtctctt attttgcctg cctactgtct acagatcaag acgtaaagct ctcagttact
     2161 actctagcac catgcctgtc tactcctacc atgatgataa tgaactggcc ttctaaaact
     2221 ctaagccagc cccaattaaa cgcttccttt tataaga
//
LOCUS       NM_001437182            1099 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 240 (Tmem240), transcript
            variant 2, mRNA.
ACCESSION   NM_001437182
VERSION     NM_001437182.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1099)
  AUTHORS   Trinidad,J.C., Barkan,D.T., Gulledge,B.F., Thalhammer,A., Sali,A.,
            Schoepfer,R. and Burlingame,A.L.
  TITLE     Global identification and characterization of both O-GlcNAcylation
            and phosphorylation at the murine synapse
  JOURNAL   Mol Cell Proteomics 11 (8), 215-229 (2012)
   PUBMED   22645316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.615456.1,
                                           SRR22582416.200667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               JAXUCZ010000005.1  171626659-171627001
            344-1099            JAXUCZ010000005.1  171627273-171628028
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1099
                     /gene="Tmem240"
                     /note="transmembrane protein 240"
                     /db_xref="GeneID:100362471"
                     /db_xref="RGD:2318117"
     exon            1..343
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..454
                     /gene="Tmem240"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 240 isoform 2"
                     /protein_id="NP_001424111.1"
                     /db_xref="GeneID:100362471"
                     /db_xref="RGD:2318117"
                     /translation="MSMSANTMIFMILGASIVMAIACLMDMNALLDRFHNYILPHLRG
                     EDRVCHCNCGR"
     misc_feature    287..>451
                     /gene="Tmem240"
                     /note="TMEM240 family; Region: TMEM240; pfam15207"
                     /db_xref="CDD:405814"
     misc_feature    287..>451
                     /gene="Tmem240"
                     /note="TMEM240 family; Region: TMEM240; pfam15207"
                     /db_xref="CDD:405814"
     exon            344..1099
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagaggg aggagggagg gggccgccgc gcggaccgca gggagccggg cgcagggagc
       61 accggagggc ggagcggagg gctgccagca acgggcgacg ggcgagcgac cccacaacag
      121 cccccacatc tctgctgcct gtgcccgcgc ctgtccccgg ggtccgcggc ggcccggcgc
      181 gcgagcgctg acctctgcgg aggcggcgcg ggctcagcat cgggccgggg ccgggagggg
      241 caccggggcc ggggggcggc gctccggccc ggcccggccc cgcccgatgt ccatgagtgc
      301 gaacaccatg atcttcatga ttctgggggc gtcgatcgtg atggccatcg cgtgcttgat
      361 ggacatgaac gcgctgctgg accgattcca taactacatc ctcccgcacc tgcggggcga
      421 ggaccgcgtc tgccactgca actgtggccg gtgagtgcgc cccggctcta ggcacgacac
      481 gcgtgatcac acttgtgcag cgggccccac ttggccggtg agccgggagc aagctgggcc
      541 gcagagcctg gctgaaagat gggggccgtt tctgcccgcc aggtgctggg ggaggggtgg
      601 ccaatgggaa ccctaggtca gccagctgcc tcccctggga aaggaagcat gactgagtct
      661 gttaggaact ccttcctcca gttcctttat agagaaaggc tgcctggtgg tggcattatg
      721 ggccaaggat cctcttggtc cagggccggg aggcctgaga gcagcatcct tgagtagtgt
      781 ccacagtgga agccaggaag ctggttaagc ctgggacagt agtcttgtct acgacccaag
      841 tcttcctcct gggcctactg tgtccatggt aggcaagtgc aggaggtcaa gataggaagg
      901 gccttccttg aggaacacct gccacaactg attattgtgc agaggaggag ctgaagtagg
      961 ctggggtttg ctcaaggtca caatgagacc caccacaccc ttcagggacc tccccttctg
     1021 tgcatgtgta gtgatgaagt cttctggcct tgcatgtttg tatgtccatg tatgaaataa
     1081 acatcttctc atgagccgc
//
LOCUS       NM_001437212            4677 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 3, mRNA.
ACCESSION   NM_001437212 XM_006250884
VERSION     NM_001437212.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4677)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4677)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4677)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4677)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4677)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4677)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4677)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4677)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250884.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.46587.1,
                                           SRR26643298.54094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-945             JAXUCZ010000014.1  34009985-34010094   c
            946-1053            JAXUCZ010000014.1  34002247-34002354   c
            1054-1147           JAXUCZ010000014.1  33995782-33995875   c
            1148-1304           JAXUCZ010000014.1  33994406-33994562   c
            1305-1331           JAXUCZ010000014.1  33983462-33983488   c
            1332-1386           JAXUCZ010000014.1  33981524-33981578   c
            1387-1442           JAXUCZ010000014.1  33980419-33980474   c
            1443-1662           JAXUCZ010000014.1  33976291-33976510   c
            1663-1800           JAXUCZ010000014.1  33972832-33972969   c
            1801-4677           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4677
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..1948
                     /gene="Fip1l1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     3"
                     /protein_id="NP_001424141.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTG
                     NSEKEAALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKASSSVGKWQDRYG
                     RAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSDRSATEVDNNFSKPPP
                     FFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPT
                     IESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWPSLVDTTKQWDYYARREKDRDRDR
                     ERDRDRERERDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRAS
                     REKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGS
                     EPVPEQESTEAAPAE"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..945
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1053
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1147
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1304
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1331
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1386
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1442
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1662
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1800
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..4677
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggtaca
      841 gcaagggaga actggaaatt cagagaaaga agcagcactt ccatctacaa aagctgagtt
      901 tacttctccg ccatcattgt tcaagactgg tctgccacca agcagaaaca gcacctcttc
      961 tcagtctcag acaagtactg cctccagaaa agccagttca agcgttggga agtggcagga
     1021 tcgatatggg agggccgagt cacctgatct aaggagatta cctggagcaa tcgatgtcat
     1081 tggtcaaaca ataaccatca gccgagtaga aggaagacgg cgtgcaaatg agaacagcaa
     1141 tatacaggtt ctttctgaca gatctgccac tgaagtagac aacaatttca gcaaaccacc
     1201 tccatttttc cctccagggg ctcctcctac tcaccttcct cctcctccat ttcttccacc
     1261 tcctccaact gtcagcactg ctccaccttt gattccacca ccaggtattc caataactgt
     1321 accacctcca ggtttccccc ctccaccagg cgctccacct ccatctctta taccgacaat
     1381 agaaagtggc cattcctctg gttacgacag ccgttctgca cgggcgtttc catatggcaa
     1441 tgttgccttt ccccacctta ccagttccgc tccctcatgg cctagccttg tggataccac
     1501 taagcagtgg gactattatg cacggagaga aaaagatcga gatcgagacc gagagagaga
     1561 ccgagacaga gaaagggaga gagaccggga cagagaaagg gagcgcaccc gggagcgaga
     1621 gcgggagcgg gaccacagcc ccaccccaag tgttttcaac agtgatgaag agcgatacag
     1681 atacagggag tatgcagaga gaggctatga gcgccacaga gctagtcggg agaaagaaga
     1741 gcggcacaga gaacgacggc acagagagaa ggaggaaaca agacacaagt cctctcgcag
     1801 taatagtaga cgtcgtcatg aaagtgaaga aggggacagt cacagaagac acaagcacaa
     1861 aaagtctaaa aggagcaaag aaggaaaaga ggctggcagc gagccggtcc ctgagcagga
     1921 gagcacggaa gctgcccctg ccgagtaggc gccacctctt atgtacgtca gccccagaaa
     1981 tagatgctat aaatctcctt atttttctgg ataatgttta agaaatgtac ctttaatctt
     2041 gttctgttag aatgaaacgt taactttttc ttttccaaaa taaaagtgtg catttttttg
     2101 tgttaagtta aaaatctttg tcttgtaata tttaaagaat aaaagacaaa aattacttta
     2161 tatctaagaa agtaatgtga ataagtcagc aggggactta gtgctaagtt ggccgtgtgt
     2221 gcagtgtggt gaggatcaag gactcactag ctttctagtg agcgggacgc tgtcggcagg
     2281 agaggtgctg tggtgcagaa gcccctctca tgtgacgtca ggcttcctct tactgctgtc
     2341 acactcctgc atctttaaga acttggacac attcttgtta tcacagtttt gatagcaggt
     2401 tttcagtggt ccatagtaac taaatggact gtttgaatct ctgactttag agatggtctg
     2461 aggcacttgg gtggccctat gatggaactt gtgtgcttcc cagcaggcac atggactggc
     2521 acagcgtcaa accacttcat ggccatctgt ttgaacaagg gtcaagggct tcagctgctg
     2581 ctaacgtgtt ttccaaggct cattggtagc atagaacgtg gggtattttt tgtaatacca
     2641 ggtccatatt aataaaaaat aaactcagtg agagtagtgt cagatcagtc attcttacta
     2701 aaaccagaac tccaggttaa aatctggact aaccccaaga aggttccaga gcagcggtgg
     2761 ggctgggaat gtgtgtgaaa ggacgaggca gttagagcca ccagtaagag gactgcggtc
     2821 acttagaaga agatattcat ctcttgttca aatcctccgc cattaaactg aaatggccat
     2881 aatgtgctgt gtcttcaact ccacttctac cacatttgac gttgccttga attaagtgtg
     2941 gcatacaaac catgtaagtt tttatgggct ttttattgaa ttaaaaaaat agaaacttaa
     3001 aagatttgga gtgatgagaa atcctccaca ccaaataaaa attaacatta gtttttattt
     3061 ttgagaacat tctctgatgt gtaacttgtt ttcataagtc atactttttc tggctttttt
     3121 tttttacaat atattcttta aatataaaaa tcgacaagat aaatacaatt ttatctagcc
     3181 tatttgtggt ttttctaaga tccatcattg gttttataaa aaagtaccag gccaggaagc
     3241 aatggtgaga gtaattttcc ctttgagttc tttgagcatc ctcgctaagc aggcgtgcat
     3301 catccccgac gtgcttctgc cgttgacagc aagaagaatg tcaccacatc tgaaaagata
     3361 cggcattgtg atcagaactg cttcaagcct gaagcgcctc aaagtggact tgggtggccc
     3421 tagggctgcc atatttgtcc tttttagttc tgatttgatt tccctcttcc cataaattct
     3481 ccaagctcca cgcagcgtgc atcaaaggta taggaaattg caaggtggga ccaaggccgg
     3541 ttctagtttt ggatttctct ctacctagct agtgctctcg tgtcttaatt tctcactctt
     3601 taggaaagta taagctgcgc tttcttccaa gtggggccaa gttttacatg tagaaagcaa
     3661 aatacttgaa tattagtttt ctgagtaatc attacctaat tcttccatca ttatacgcgg
     3721 gtgttccctc gacgatggat ttgataaaaa aaggttggtt accactgtat tcttcataac
     3781 ctcccacaat gcagaagccc aggcttcccg ctgtgttcct tcgtagtatc acatccttac
     3841 agttatataa gtacctgaaa cagaatgtaa ttagtggatg tacagttgag tttactagtt
     3901 gtgactcctt tcattcattt ttttggggga cacttttaaa atgaaaaata ctgcatatgt
     3961 ctccatcaga agtgacagca actttttatg ctcttagtca gcttttgcat ttgatctctc
     4021 ttttccatag ccaaataccc tttcaacaaa aggagttagt attatgttct attcatgtct
     4081 ctgctgagaa aaatggccac atattttggt taaggcgcag taatgaatgc atgagccaaa
     4141 agttggatgt gtctcagtac ttcttattcc ccacagtaga acatactgag ggaatatcat
     4201 ttttatattc ttgggggctt acataatttg taaagaagac aaacattctc tgaattagcg
     4261 attaatcgca aggacaataa ttttaactta tgctaatgaa cttatactca cacagactta
     4321 gagaagacta gagaaagtga atggaaattg ggccataaaa tagtggagca gttgtcggac
     4381 agtaagtggc atagctgaag cagtcagggg aagggaagga gcacagctgg cctgagagcc
     4441 agtacagcct tcagctggga tagccgcggc taagtgtgag cagctgcact acagtagact
     4501 gtcggaagat ggggtcgctc tgggacccct tgtctgccgc atgtgtctag gaactgcttt
     4561 tgactggaag atagtatttt ttgttgttag aattgaagat gtcttgttta tagactgtac
     4621 cttaaaataa tcagttgctt tttgataatc aataaaaatg atcttgtgaa atattaa
//
LOCUS       NM_001437166            2388 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 3, mRNA.
ACCESSION   NM_001437166
VERSION     NM_001437166.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77785.1,
                                           SRR26643286.44721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-515             JAXUCZ010000018.1  69732094-69732221
            516-615             JAXUCZ010000018.1  69732881-69732980
            616-762             JAXUCZ010000018.1  69735312-69735458
            763-948             JAXUCZ010000018.1  69736741-69736926
            949-1104            JAXUCZ010000018.1  69740845-69741000
            1105-1212           JAXUCZ010000018.1  69741592-69741699
            1213-2388           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2388
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            388..515
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1266
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 1"
                     /protein_id="NP_001424095.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MCSKTKMTEKTNPHPPLRPTESAALMRGCLRGLESVSFMEQMQR
                     IPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREPLKNLFFVLAERARGPNPRKR
                     HLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQ
                     GQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQD
                     SLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEI
                     LLFFYANKIL"
     misc_feature    673..1119
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    673..1119
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    787..888
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    787..888
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    916..1005
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    916..1005
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            516..615
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            616..762
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            763..948
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1104
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1212
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..2388
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagggc catctgacct cgaaaatgtg ctcaaaaaca
      421 aagatgacag agaagacaaa tccccaccca cctctacgcc ccaccgaatc agctgctctg
      481 atgcgtggct gcctaagagg gctggaatct gtcagtttca tggaacaaat gcagagaatc
      541 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      601 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      661 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      721 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca agcaggtgag aaagtataag
      781 aaagttatgc ttgacctgct ggtacacggg ctgtatgatc ctgtgagttc cgaagtcatt
      841 catgagagtg tgaagacgct gactatcatg ttgggcaaga tccagggcca acggctgggc
      901 tccttcttca tagacatcac ccttcagacc cggaccctat tggatgatga ggatgacagc
      961 gtgcgctact cagcctttgt cctctttggg cagttggctg catttgctgg gcggaaatgg
     1021 aagaagttct tcacccacca ggtcaaccag acccaagatt ccctcctaag ccatttgcag
     1081 gacgaaagcc ctcaggttgc caaggcttgc acaatggctg ttcaagcctg tgttccatac
     1141 ctgaaaccca gaaaggagca gagtttccaa agtgaagaag accagaagaa ccgcaggctt
     1201 tcccagcaac tgagccacta ccatccagag atcctgctgt tcttctatgc caataaaatc
     1261 ctgtaggtcc agagcagcag agaaagccca cgggagtgcc ctgccccggc atggaatttc
     1321 ccatctgtct cataggatac ctctttgact ctcgagtgat tgtaagagaa aagaggatgt
     1381 cagagagcaa ctgaaaaaaa aatcaccctg gagtgcacgc aaagtaaaat tctatgcaag
     1441 tgtgtgcaca tacatgcaca tgactgtgga ggtcagagga cgacctcact gctgttccta
     1501 aggcgtcatc catctttcca ctgaaacagg atctttgact ggcctggggc ttgcaggagc
     1561 ttagactagg cttgatagct agtgagccag ctctggggtt ataaccacag tccatcgaac
     1621 caaccgtttt tgactgtgcc aaattcaggc ccttatacct acttgtgctg actaagccgt
     1681 ctccccagcc cagtagatgc acacttcctt aaaacattta acatgcatga tgtcccaatc
     1741 cctcctttct cactccctct ctgccaggtg acacacattt ataatatgta acttctgagg
     1801 cttgggggaa caattgttac cttaaacatt tttaaactgt atttgttttt gatagtttgc
     1861 tatttgctac ggaccaggag accaaggagc tggcttacaa tgtgtcttta atttcggatg
     1921 atcttaaaat gtcatggtct taaaatcgtc tttaaaaaga acaacaagga aaagaaatat
     1981 tgttgaaaat ccactgaatg atgataagtt acagaataaa aacagtaaca tttactgaga
     2041 atgcttacaa cttatttcgg tactgtggtg gtttggatga gcgaccctgc aggcttacgt
     2101 atttgaatgc ttggtccctt cttagtggaa gtgtttagga ggggttagag ggtgtgtata
     2161 tcactggaga tggaatttga gacttcagaa gcccaagcaa ggccctgtct gtctgtctgt
     2221 ctgtctgtct gtccgtctct tattttgcct gcctactgtc tacagatcaa gacgtaaagc
     2281 tctcagttac tactctagca ccatgcctgt ctactcctac catgatgata atgaactggc
     2341 cttctaaaac tctaagccag ccccaattaa acgcttcctt ttataaga
//
LOCUS       NM_001437173            2116 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 10, mRNA.
ACCESSION   NM_001437173
VERSION     NM_001437173.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35233.1,
                                           SRR26643429.54679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000018.1  69725889-69725982
            95-246              JAXUCZ010000018.1  69726124-69726275
            247-346             JAXUCZ010000018.1  69732881-69732980
            347-493             JAXUCZ010000018.1  69735312-69735458
            494-676             JAXUCZ010000018.1  69736744-69736926
            677-832             JAXUCZ010000018.1  69740845-69741000
            833-940             JAXUCZ010000018.1  69741592-69741699
            941-2116            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2116
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..94
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            95..246
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    125..127
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            247..346
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..994
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 5 is encoded by transcript variant 10;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 5"
                     /protein_id="NP_001424102.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVS
                     SEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAA
                     FAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSE
                     EDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    404..847
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    404..847
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            347..493
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            494..676
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            677..832
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            833..940
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            941..2116
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtaagg aaaccagggc tgggaaaatc
      121 tcgctgactc accacatttg gaggccaatc ccgaatcggt ggaacaacgc gcctcccgag
      181 agacccagga ctagcctcca gccccgaaac agcggttctt cacgtgacag tcaccccagg
      241 agccagtttc atggaacaaa tgcagagaat cccgaaccag cccctcccca cccctgcttc
      301 tcagtccaag aagaggagga caccactgtc atctttcttt tccaaggtct cttggaaact
      361 gaggttgcag aagcgggaac ctttgaagaa tctgtttttc gtcttggcag aaagagcccg
      421 gggtcctaat cctagaaagc gccatctagc aatgagaggc ctgggtatct tggcccatga
      481 agctcctgac aaggtgagaa agtataagaa agttatgctt gacctgctgg tacacgggct
      541 gtatgatcct gtgagttccg aagtcattca tgagagtgtg aagacgctga ctatcatgtt
      601 gggcaagatc cagggccaac ggctgggctc cttcttcata gacatcaccc ttcagacccg
      661 gaccctattg gatgatgagg atgacagcgt gcgctactca gcctttgtcc tctttgggca
      721 gttggctgca tttgctgggc ggaaatggaa gaagttcttc acccaccagg tcaaccagac
      781 ccaagattcc ctcctaagcc atttgcagga cgaaagccct caggttgcca aggcttgcac
      841 aatggctgtt caagcctgtg ttccatacct gaaacccaga aaggagcaga gtttccaaag
      901 tgaagaagac cagaagaacc gcaggctttc ccagcaactg agccactacc atccagagat
      961 cctgctgttc ttctatgcca ataaaatcct gtaggtccag agcagcagag aaagcccacg
     1021 ggagtgccct gccccggcat ggaatttccc atctgtctca taggatacct ctttgactct
     1081 cgagtgattg taagagaaaa gaggatgtca gagagcaact gaaaaaaaaa tcaccctgga
     1141 gtgcacgcaa agtaaaattc tatgcaagtg tgtgcacata catgcacatg actgtggagg
     1201 tcagaggacg acctcactgc tgttcctaag gcgtcatcca tctttccact gaaacaggat
     1261 ctttgactgg cctggggctt gcaggagctt agactaggct tgatagctag tgagccagct
     1321 ctggggttat aaccacagtc catcgaacca accgtttttg actgtgccaa attcaggccc
     1381 ttatacctac ttgtgctgac taagccgtct ccccagccca gtagatgcac acttccttaa
     1441 aacatttaac atgcatgatg tcccaatccc tcctttctca ctccctctct gccaggtgac
     1501 acacatttat aatatgtaac ttctgaggct tgggggaaca attgttacct taaacatttt
     1561 taaactgtat ttgtttttga tagtttgcta tttgctacgg accaggagac caaggagctg
     1621 gcttacaatg tgtctttaat ttcggatgat cttaaaatgt catggtctta aaatcgtctt
     1681 taaaaagaac aacaaggaaa agaaatattg ttgaaaatcc actgaatgat gataagttac
     1741 agaataaaaa cagtaacatt tactgagaat gcttacaact tatttcggta ctgtggtggt
     1801 ttggatgagc gaccctgcag gcttacgtat ttgaatgctt ggtcccttct tagtggaagt
     1861 gtttaggagg ggttagaggg tgtgtatatc actggagatg gaatttgaga cttcagaagc
     1921 ccaagcaagg ccctgtctgt ctgtctgtct gtctgtctgt ccgtctctta ttttgcctgc
     1981 ctactgtcta cagatcaaga cgtaaagctc tcagttacta ctctagcacc atgcctgtct
     2041 actcctacca tgatgataat gaactggcct tctaaaactc taagccagcc ccaattaaac
     2101 gcttcctttt ataaga
//
LOCUS       NM_001437187            4144 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus adducin 1 (Add1), transcript variant 6, mRNA.
ACCESSION   NM_001437187 XM_017599065
VERSION     NM_001437187.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 4144)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 4144)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_017599065.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.54878.1,
                                           SRR26360194.2431842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000014.1  80391692-80391851   c
            161-375             JAXUCZ010000014.1  80364782-80364996   c
            376-538             JAXUCZ010000014.1  80361344-80361506   c
            539-690             JAXUCZ010000014.1  80360265-80360416   c
            691-771             JAXUCZ010000014.1  80355305-80355385   c
            772-921             JAXUCZ010000014.1  80354818-80354967   c
            922-1065            JAXUCZ010000014.1  80352381-80352524   c
            1066-1164           JAXUCZ010000014.1  80352191-80352289   c
            1165-1341           JAXUCZ010000014.1  80351463-80351639   c
            1342-1686           JAXUCZ010000014.1  80348846-80349190   c
            1687-1788           JAXUCZ010000014.1  80346327-80346428   c
            1789-1878           JAXUCZ010000014.1  80345653-80345742   c
            1879-1971           JAXUCZ010000014.1  80344873-80344965   c
            1972-2128           JAXUCZ010000014.1  80340292-80340448   c
            2129-2227           JAXUCZ010000014.1  80337025-80337123   c
            2228-2264           JAXUCZ010000014.1  80336380-80336416   c
            2265-4144           JAXUCZ010000014.1  80333242-80335121   c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4144
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..160
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..375
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Add1"
                     /note="upstream in-frame stop codon"
     CDS             181..2265
                     /gene="Add1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     alpha-adducin; erythrocyte adducin subunit alpha;
                     alpha-ADD; adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 6"
                     /protein_id="NP_001424116.1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFFYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKVWTNITHDHVKPLLQSLSSGVCVPSCITNCLWTKEDG
                     HRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQ
                     DAPLSDCTETIEGLERTEQTFSPAKSVSFRKGELVTASKAIIEKEYQPHVIVSTTGPN
                     PFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEG
                     AGDGCAKEYLLP"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     exon            376..538
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1065
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1341
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1686
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1788
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1878
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1971
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2128
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2227
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2264
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..4144
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaggg gtgagggttg agggcgggag aggacgaggg ctgctgcagg cggcgggggt
       61 gcgcggcagc cagggggcgg agcccagcgc gagccgcagg cgaggcggcg gccgcactcg
      121 gacccgggaa gctgtgcgct tttcccgatt ctccgcggag gatcctagaa acattgtgca
      181 atgaatggtg acacgcgggc cgcagtggtg acctcaccac ctccaaccac agcccctcac
      241 aaggagaggt actttgacag agtcgatgag aacaatccag aatatttgcg ggagaggaac
      301 atggcaccag accttcgtca ggacttcaat atgatggagc agaagaagag ggtgtctatg
      361 attctgcaga gtcccgcctt ctgtgaagag ctggagtcta tgatacagga gcagtttaag
      421 aaggggaaga accctacagg cctgttggca ttacagcaga ttgcggattt catgacggcg
      481 agtgtgccca atgtctaccc ggcagctcca caaggaggaa tggccgccct gaacatgagt
      541 cttggtatgg ttactcctgt gaatgacctt agaggatctg attctattgc atatgacaag
      601 ggggagaagt tactgcgatg taagctggca gcattttaca gactagcaga cctctttggc
      661 tggtctcagc ttatctacaa tcacatcaca accagagtga actctgagca ggagcacttc
      721 ctcatcgtgc ctttcggact tctctacagt gaagtgactg cgtccagcct ggttaaggtc
      781 aatctacaag gagacatagt agaccgcgga agtactaacc tgggagtcaa ccaggccggc
      841 ttcaccttgc actcggccat ttatgctgca cgaccagatg ccaagtgcat tgtgcacatt
      901 cacacaccag caggggctgc ggtctctgca atgaagtgtg ggctcttgcc tatttccccg
      961 gaggcgcttt cccttggaga ggttgcttat catgactatc atggcattct ggttgatgaa
     1021 gaggaaaaaa ttttgattca gaagaatctg ggccctaaaa gcaaggttct cattctccgg
     1081 aatcacgggc tcgtgtcagt tggagagagt gtggaggagg ccttctttta tatccacaac
     1141 cttgtggttg catgtgagat ccaggttcga actctggcaa gtgctggagg accagacaac
     1201 ttagttctgc tggatcctgg gaagtacaaa gccaaatccc gttctccagg gactccagca
     1261 ggggaaggct ctggatcacc tcccaagtgg cagattgggg agcaggaatt tgaagctctt
     1321 atgcggatgc tcgataatct gggctacaga actggctacc cctatcgata ccctgctctg
     1381 agagagagat ctaaaaagta cagcgatgtg gaagtccctg ccagtgtcac cggccactcc
     1441 tttgctagtg acggcgattc gggcacttgc tcgccgctca gacacagttt tcagaagcag
     1501 cagcgagaga agacaagatg gctgaactct ggccggggtg atgacgcttc tgaggagggg
     1561 cagaacggaa gcagtcccaa gtcgaagact aaggtgtgga cgaacattac acacgatcac
     1621 gtgaaaccct tgctgcagtc tctctcgtcc ggtgtctgcg tgccaagctg tattaccaac
     1681 tgcttgtgga ctaaagagga tggacataga acttccacct ctgctgtccc taacctgttt
     1741 gttccattga acactaaccc aaaagaggtc caggagatga ggaacaagat tcgagagcag
     1801 aacttacagg acattaagac ggcaggacct cagtcgcagg ttttgtgtgg tgtgatgatg
     1861 gacagaagcc ttgtccagga tgcacccctc tctgactgta cggaaactat cgaagggctc
     1921 gagcgtacag agcagacctt tagtcccgct aaatctgtct cttttagaaa gggggagctc
     1981 gtgacggcct ccaaagccat cattgagaag gaataccagc ctcatgtaat tgtgagcacc
     2041 acaggtccca accccttcaa cacgctcaca gaccgtgaac tagaggaata ccgccgagag
     2101 gtggagcgga agcagaaggg ctctgaagag aacctggacg agacaagaga gcagaaagag
     2161 aagagtcctc cagaccagtc agctgttccc aacactccgc ccagcactcc cgtcaagctt
     2221 gaaggagcag gagacggatg tgctaaagag tacctgttac cctagccttc cccaggagcc
     2281 gacatccagg gatggcagcg atgccaccac ctccaagccg actccccctg acctctcccc
     2341 tgatgagcct tcagaagcac ttgccttccc aacagtggca gaggaagccc atgcttcccc
     2401 agacaccact cagccccttg ctgaggctga ccctgagcca gcctcagcct cagctccagg
     2461 agctgaagag gtagcctccc ctgccactga ggaggggtct cccatggacc ctggcagcga
     2521 tgggtctcca ggcaagtccc catccaagaa gaagaagaag ttccgcaccc cgtccttcct
     2581 gaagaagagc aagaagaaga gtgactcctg aaggcccacc ctgcatactg tcgtgtctga
     2641 aggcctggct ctgccaggac tccctcctct gtcttgtgtt ctgtcctctc gtgtaatgga
     2701 atgcaaaaag ccaagacctc catgtaacta gagccccctc ccatgtatgg tcagcccctg
     2761 caccagtgct aacccagtgt gtgctcagcc cctctaccct gggccttggg ttctgtgggg
     2821 agttgggctt agcctgcacc tgtgagttgt gcccccctgc aggaggggga cactgaatcc
     2881 tggtcctggc tggaaggcat aggaggcttc tgccagctct ggttacagcg tcaccctcct
     2941 gagccttgcc tctcactctc ctttctgtcg tgagtattga attgtctgct cagtttccct
     3001 ccaccctgtg gagtctcagg tggctgattt ggactcggct ttgctggcat cctctgctcc
     3061 gtgatgtcag ttatccccat acacaggtat ccacataccc cagccatggt ctgagaaaac
     3121 actctcatgt ccatccgcgg cccacactgt ggctgcctta aagacatggg ttaagtctgc
     3181 tgccctagca gtgagcaacc ctttgtatac ccagcacaac gctatgcatg gtctaactga
     3241 tgaccccatg accaaaacca cattcaggcg ctcatagttg accttaccgg ggtcttgcat
     3301 tcccatctta gggaacagat accaggaggg ggaagagtcc tttctaaaac tttgtttcag
     3361 caggtttgcg atttagcctc catttttact gtgaacttga acaggccact ttttgcgtta
     3421 gtttttgttg tagagcctat gacagactgc agcagaacac tcttgacttg tgtggggagg
     3481 ttttgtagga acagggacca taactcagtc tgaacgatgc cctggttttg atagggatgg
     3541 taactcatgg ttgaagctgg ctttggaggt gccatctaat gtcttgcatc attcatggag
     3601 cccatgacct tcttggtcat cccttatgaa tttttaccta acttttatcc ctggaaaagg
     3661 gcttgaaact gctttagtga gtggggaagc cgagtgtcag gtggaatcct aaggggcctt
     3721 gttccaggag ctgccactgc cagcctgact aggagaggga gcctgctggg gccctccacg
     3781 cccctgctgg gttgggcctc atagagcggg tgctcggatg tggacagaac cctgtgatct
     3841 cccaatgggg caccaagcag gaccccacag cctgctgtac tgctagtccc actagtcacc
     3901 acggtggcct gagctctcac ctggtcctga gtcccctcat ctggactcct cctcgtcttc
     3961 cttctggccc ttcctttatc ccacatatgc aatgacttct cacttttgta gtctaatctt
     4021 tgtattacac acggaatatc gctgcatata tggacagact tggaggacag gtcctgtgtg
     4081 tcctttcctc gtcgtaacag gtcttactca caaataaaag tctttaagca gtttctttgt
     4141 ctaa
//
LOCUS       NM_016990               3921 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus adducin 1 (Add1), transcript variant 1, mRNA.
ACCESSION   NM_016990
VERSION     NM_016990.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3921)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3921)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3921)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3921)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 3921)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 3921)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 3921)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 3921)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 3921)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 3921)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced NM_016990.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107657.1, SRR21887623.2491154.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000014.1  80391692-80391851   c
            161-375             JAXUCZ010000014.1  80364782-80364996   c
            376-538             JAXUCZ010000014.1  80361344-80361506   c
            539-690             JAXUCZ010000014.1  80360265-80360416   c
            691-771             JAXUCZ010000014.1  80355305-80355385   c
            772-921             JAXUCZ010000014.1  80354818-80354967   c
            922-1065            JAXUCZ010000014.1  80352381-80352524   c
            1066-1164           JAXUCZ010000014.1  80352191-80352289   c
            1165-1341           JAXUCZ010000014.1  80351463-80351639   c
            1342-1593           JAXUCZ010000014.1  80348939-80349190   c
            1594-1695           JAXUCZ010000014.1  80346327-80346428   c
            1696-1785           JAXUCZ010000014.1  80345653-80345742   c
            1786-1942           JAXUCZ010000014.1  80340292-80340448   c
            1943-2041           JAXUCZ010000014.1  80337025-80337123   c
            2042-3921           JAXUCZ010000014.1  80333242-80335121   c
FEATURES             Location/Qualifiers
     source          1..3921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3921
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..160
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..375
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Add1"
                     /note="upstream in-frame stop codon"
     CDS             181..2388
                     /gene="Add1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-adducin; erythrocyte adducin subunit alpha;
                     alpha-ADD; adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 1"
                     /protein_id="NP_058686.3"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFFYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIRE
                     QNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFNT
                     LTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEGGLPQ
                     EPTSRDGSDATTSKPTPPDLSPDEPSEALAFPTVAEEAHASPDTTQPLAEADPEPASA
                     SAPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS"
     misc_feature    181..243
                     /gene="Add1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63028.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    181..183
                     /gene="Add1"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); acetylation site"
     misc_feature    214..216
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    355..357
                     /gene="Add1"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    370..372
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    1171..1173
                     /gene="Add1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1180..1182
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1237..1239
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1243..1245
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1252..1254
                     /gene="Add1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1270..1272
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1276..1278
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1402..1404
                     /gene="Add1"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1432..1638
                     /gene="Add1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63028.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1459..1461
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1465..1467
                     /gene="Add1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1471..1473
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1486..1488
                     /gene="Add1"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1513..1515
                     /gene="Add1"
                     /note="Phosphothreonine, by ROCK2.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1570..1572
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1573..1575
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1618..1620
                     /gene="Add1"
                     /note="Phosphothreonine, by ROCK2.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1621..1623
                     /gene="Add1"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1849..>2298
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    1849..>2298
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    1906..2385
                     /gene="Add1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63028.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1936..1938
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1978..1980
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    1993..1995
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2008..2010
                     /gene="Add1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2017..2019
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC0; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2020..2022
                     /gene="Add1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2293..2295
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2302..2304
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2314..2316
                     /gene="Add1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2320..2322
                     /gene="Add1"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     misc_feature    2323..2376
                     /gene="Add1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63028.2);
                     Region: Interaction with calmodulin.
                     /evidence=ECO:0000255"
     misc_feature    2350..2352
                     /gene="Add1"
                     /note="Phosphoserine, by PKA and PKC.
                     /evidence=ECO:0000250|UniProtKB:P35611; propagated from
                     UniProtKB/Swiss-Prot (Q63028.2); phosphorylation site"
     exon            376..538
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1065
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1341
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1593
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1695
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1785
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1942
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2041
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..3921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaggg gtgagggttg agggcgggag aggacgaggg ctgctgcagg cggcgggggt
       61 gcgcggcagc cagggggcgg agcccagcgc gagccgcagg cgaggcggcg gccgcactcg
      121 gacccgggaa gctgtgcgct tttcccgatt ctccgcggag gatcctagaa acattgtgca
      181 atgaatggtg acacgcgggc cgcagtggtg acctcaccac ctccaaccac agcccctcac
      241 aaggagaggt actttgacag agtcgatgag aacaatccag aatatttgcg ggagaggaac
      301 atggcaccag accttcgtca ggacttcaat atgatggagc agaagaagag ggtgtctatg
      361 attctgcaga gtcccgcctt ctgtgaagag ctggagtcta tgatacagga gcagtttaag
      421 aaggggaaga accctacagg cctgttggca ttacagcaga ttgcggattt catgacggcg
      481 agtgtgccca atgtctaccc ggcagctcca caaggaggaa tggccgccct gaacatgagt
      541 cttggtatgg ttactcctgt gaatgacctt agaggatctg attctattgc atatgacaag
      601 ggggagaagt tactgcgatg taagctggca gcattttaca gactagcaga cctctttggc
      661 tggtctcagc ttatctacaa tcacatcaca accagagtga actctgagca ggagcacttc
      721 ctcatcgtgc ctttcggact tctctacagt gaagtgactg cgtccagcct ggttaaggtc
      781 aatctacaag gagacatagt agaccgcgga agtactaacc tgggagtcaa ccaggccggc
      841 ttcaccttgc actcggccat ttatgctgca cgaccagatg ccaagtgcat tgtgcacatt
      901 cacacaccag caggggctgc ggtctctgca atgaagtgtg ggctcttgcc tatttccccg
      961 gaggcgcttt cccttggaga ggttgcttat catgactatc atggcattct ggttgatgaa
     1021 gaggaaaaaa ttttgattca gaagaatctg ggccctaaaa gcaaggttct cattctccgg
     1081 aatcacgggc tcgtgtcagt tggagagagt gtggaggagg ccttctttta tatccacaac
     1141 cttgtggttg catgtgagat ccaggttcga actctggcaa gtgctggagg accagacaac
     1201 ttagttctgc tggatcctgg gaagtacaaa gccaaatccc gttctccagg gactccagca
     1261 ggggaaggct ctggatcacc tcccaagtgg cagattgggg agcaggaatt tgaagctctt
     1321 atgcggatgc tcgataatct gggctacaga actggctacc cctatcgata ccctgctctg
     1381 agagagagat ctaaaaagta cagcgatgtg gaagtccctg ccagtgtcac cggccactcc
     1441 tttgctagtg acggcgattc gggcacttgc tcgccgctca gacacagttt tcagaagcag
     1501 cagcgagaga agacaagatg gctgaactct ggccggggtg atgacgcttc tgaggagggg
     1561 cagaacggaa gcagtcccaa gtcgaagact aagtggacta aagaggatgg acatagaact
     1621 tccacctctg ctgtccctaa cctgtttgtt ccattgaaca ctaacccaaa agaggtccag
     1681 gagatgagga acaagattcg agagcagaac ttacaggaca ttaagacggc aggacctcag
     1741 tcgcaggttt tgtgtggtgt gatgatggac agaagccttg tccaggggga gctcgtgacg
     1801 gcctccaaag ccatcattga gaaggaatac cagcctcatg taattgtgag caccacaggt
     1861 cccaacccct tcaacacgct cacagaccgt gaactagagg aataccgccg agaggtggag
     1921 cggaagcaga agggctctga agagaacctg gacgagacaa gagagcagaa agagaagagt
     1981 cctccagacc agtcagctgt tcccaacact ccgcccagca ctcccgtcaa gcttgaagga
     2041 ggccttcccc aggagccgac atccagggat ggcagcgatg ccaccacctc caagccgact
     2101 ccccctgacc tctcccctga tgagccttca gaagcacttg ccttcccaac agtggcagag
     2161 gaagcccatg cttccccaga caccactcag ccccttgctg aggctgaccc tgagccagcc
     2221 tcagcctcag ctccaggagc tgaagaggta gcctcccctg ccactgagga ggggtctccc
     2281 atggaccctg gcagcgatgg gtctccaggc aagtccccat ccaagaagaa gaagaagttc
     2341 cgcaccccgt ccttcctgaa gaagagcaag aagaagagtg actcctgaag gcccaccctg
     2401 catactgtcg tgtctgaagg cctggctctg ccaggactcc ctcctctgtc ttgtgttctg
     2461 tcctctcgtg taatggaatg caaaaagcca agacctccat gtaactagag ccccctccca
     2521 tgtatggtca gcccctgcac cagtgctaac ccagtgtgtg ctcagcccct ctaccctggg
     2581 ccttgggttc tgtggggagt tgggcttagc ctgcacctgt gagttgtgcc cccctgcagg
     2641 agggggacac tgaatcctgg tcctggctgg aaggcatagg aggcttctgc cagctctggt
     2701 tacagcgtca ccctcctgag ccttgcctct cactctcctt tctgtcgtga gtattgaatt
     2761 gtctgctcag tttccctcca ccctgtggag tctcaggtgg ctgatttgga ctcggctttg
     2821 ctggcatcct ctgctccgtg atgtcagtta tccccataca caggtatcca cataccccag
     2881 ccatggtctg agaaaacact ctcatgtcca tccgcggccc acactgtggc tgccttaaag
     2941 acatgggtta agtctgctgc cctagcagtg agcaaccctt tgtataccca gcacaacgct
     3001 atgcatggtc taactgatga ccccatgacc aaaaccacat tcaggcgctc atagttgacc
     3061 ttaccggggt cttgcattcc catcttaggg aacagatacc aggaggggga agagtccttt
     3121 ctaaaacttt gtttcagcag gtttgcgatt tagcctccat ttttactgtg aacttgaaca
     3181 ggccactttt tgcgttagtt tttgttgtag agcctatgac agactgcagc agaacactct
     3241 tgacttgtgt ggggaggttt tgtaggaaca gggaccataa ctcagtctga acgatgccct
     3301 ggttttgata gggatggtaa ctcatggttg aagctggctt tggaggtgcc atctaatgtc
     3361 ttgcatcatt catggagccc atgaccttct tggtcatccc ttatgaattt ttacctaact
     3421 tttatccctg gaaaagggct tgaaactgct ttagtgagtg gggaagccga gtgtcaggtg
     3481 gaatcctaag gggccttgtt ccaggagctg ccactgccag cctgactagg agagggagcc
     3541 tgctggggcc ctccacgccc ctgctgggtt gggcctcata gagcgggtgc tcggatgtgg
     3601 acagaaccct gtgatctccc aatggggcac caagcaggac cccacagcct gctgtactgc
     3661 tagtcccact agtcaccacg gtggcctgag ctctcacctg gtcctgagtc ccctcatctg
     3721 gactcctcct cgtcttcctt ctggcccttc ctttatccca catatgcaat gacttctcac
     3781 ttttgtagtc taatctttgt attacacacg gaatatcgct gcatatatgg acagacttgg
     3841 aggacaggtc ctgtgtgtcc tttcctcgtc gtaacaggtc ttactcacaa ataaaagtct
     3901 ttaagcagtt tctttgtcta a
//
LOCUS       NM_001437177            2212 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 14, mRNA.
ACCESSION   NM_001437177
VERSION     NM_001437177.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1765616.1,
                                           SRR26360186.1376871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-487             JAXUCZ010000018.1  69732881-69732980
            488-634             JAXUCZ010000018.1  69735312-69735458
            635-817             JAXUCZ010000018.1  69736744-69736926
            818-928             JAXUCZ010000018.1  69740890-69741000
            929-1036            JAXUCZ010000018.1  69741592-69741699
            1037-2212           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2212
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            388..487
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1090
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 7 is encoded by transcript variant 14;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 7"
                     /protein_id="NP_001424106.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVS
                     SEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDLAAFAGRKWKKFFTHQVN
                     QTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHY
                     HPEILLFFYANKIL"
     exon            488..634
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            635..817
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            818..928
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1036
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..2212
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagttt catggaacaa atgcagagaa tcccgaacca
      421 gcccctcccc acccctgctt ctcagtccaa gaagaggagg acaccactgt catctttctt
      481 ttccaaggtc tcttggaaac tgaggttgca gaagcgggaa cctttgaaga atctgttttt
      541 cgtcttggca gaaagagccc ggggtcctaa tcctagaaag cgccatctag caatgagagg
      601 cctgggtatc ttggcccatg aagctcctga caaggtgaga aagtataaga aagttatgct
      661 tgacctgctg gtacacgggc tgtatgatcc tgtgagttcc gaagtcattc atgagagtgt
      721 gaagacgctg actatcatgt tgggcaagat ccagggccaa cggctgggct ccttcttcat
      781 agacatcacc cttcagaccc ggaccctatt ggatgatttg gctgcatttg ctgggcggaa
      841 atggaagaag ttcttcaccc accaggtcaa ccagacccaa gattccctcc taagccattt
      901 gcaggacgaa agccctcagg ttgccaaggc ttgcacaatg gctgttcaag cctgtgttcc
      961 atacctgaaa cccagaaagg agcagagttt ccaaagtgaa gaagaccaga agaaccgcag
     1021 gctttcccag caactgagcc actaccatcc agagatcctg ctgttcttct atgccaataa
     1081 aatcctgtag gtccagagca gcagagaaag cccacgggag tgccctgccc cggcatggaa
     1141 tttcccatct gtctcatagg atacctcttt gactctcgag tgattgtaag agaaaagagg
     1201 atgtcagaga gcaactgaaa aaaaaatcac cctggagtgc acgcaaagta aaattctatg
     1261 caagtgtgtg cacatacatg cacatgactg tggaggtcag aggacgacct cactgctgtt
     1321 cctaaggcgt catccatctt tccactgaaa caggatcttt gactggcctg gggcttgcag
     1381 gagcttagac taggcttgat agctagtgag ccagctctgg ggttataacc acagtccatc
     1441 gaaccaaccg tttttgactg tgccaaattc aggcccttat acctacttgt gctgactaag
     1501 ccgtctcccc agcccagtag atgcacactt ccttaaaaca tttaacatgc atgatgtccc
     1561 aatccctcct ttctcactcc ctctctgcca ggtgacacac atttataata tgtaacttct
     1621 gaggcttggg ggaacaattg ttaccttaaa catttttaaa ctgtatttgt ttttgatagt
     1681 ttgctatttg ctacggacca ggagaccaag gagctggctt acaatgtgtc tttaatttcg
     1741 gatgatctta aaatgtcatg gtcttaaaat cgtctttaaa aagaacaaca aggaaaagaa
     1801 atattgttga aaatccactg aatgatgata agttacagaa taaaaacagt aacatttact
     1861 gagaatgctt acaacttatt tcggtactgt ggtggtttgg atgagcgacc ctgcaggctt
     1921 acgtatttga atgcttggtc ccttcttagt ggaagtgttt aggaggggtt agagggtgtg
     1981 tatatcactg gagatggaat ttgagacttc agaagcccaa gcaaggccct gtctgtctgt
     2041 ctgtctgtct gtctgtccgt ctcttatttt gcctgcctac tgtctacaga tcaagacgta
     2101 aagctctcag ttactactct agcaccatgc ctgtctactc ctaccatgat gataatgaac
     2161 tggccttcta aaactctaag ccagccccaa ttaaacgctt ccttttataa ga
//
LOCUS       NM_001437184            4059 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus adducin 1 (Add1), transcript variant 3, mRNA.
ACCESSION   NM_001437184 XM_006251159
VERSION     NM_001437184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4059)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4059)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4059)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4059)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 4059)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 4059)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 4059)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 4059)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 4059)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 4059)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006251159.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000014.1  80391692-80391851   c
            161-375             JAXUCZ010000014.1  80364782-80364996   c
            376-538             JAXUCZ010000014.1  80361344-80361506   c
            539-690             JAXUCZ010000014.1  80360265-80360416   c
            691-771             JAXUCZ010000014.1  80355305-80355385   c
            772-921             JAXUCZ010000014.1  80354818-80354967   c
            922-1065            JAXUCZ010000014.1  80352381-80352524   c
            1066-1164           JAXUCZ010000014.1  80352191-80352289   c
            1165-1341           JAXUCZ010000014.1  80351463-80351639   c
            1342-1593           JAXUCZ010000014.1  80348939-80349190   c
            1594-1638           JAXUCZ010000014.1  80348287-80348331   c
            1639-1740           JAXUCZ010000014.1  80346327-80346428   c
            1741-1830           JAXUCZ010000014.1  80345653-80345742   c
            1831-1923           JAXUCZ010000014.1  80344873-80344965   c
            1924-2080           JAXUCZ010000014.1  80340292-80340448   c
            2081-2179           JAXUCZ010000014.1  80337025-80337123   c
            2180-4059           JAXUCZ010000014.1  80333242-80335121   c
FEATURES             Location/Qualifiers
     source          1..4059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4059
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..160
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..375
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Add1"
                     /note="upstream in-frame stop codon"
     CDS             181..2526
                     /gene="Add1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     alpha-adducin; erythrocyte adducin subunit alpha;
                     alpha-ADD; adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 3"
                     /protein_id="NP_001424113.1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFFYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKPPNAYASCPPHGLLHWTKEDGHRTSTSAVPNLFVPLN
                     TNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQDAPLSDCTETIEGLER
                     TEQTFSPAKSVSFRKGELVTASKAIIEKEYQPHVIVSTTGPNPFNTLTDRELEEYRRE
                     VERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEGGLPQEPTSRDGSDATT
                     SKPTPPDLSPDEPSEALAFPTVAEEAHASPDTTQPLAEADPEPASASAPGAEEVASPA
                     TEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    1987..>2436
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     misc_feature    1987..>2436
                     /gene="Add1"
                     /note="hypothetical protein; Provisional; Region:
                     PHA03169"
                     /db_xref="CDD:223003"
     exon            376..538
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1065
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1341
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1593
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1638
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1740
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1830
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1923
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2080
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2179
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..4059
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaggg gtgagggttg agggcgggag aggacgaggg ctgctgcagg cggcgggggt
       61 gcgcggcagc cagggggcgg agcccagcgc gagccgcagg cgaggcggcg gccgcactcg
      121 gacccgggaa gctgtgcgct tttcccgatt ctccgcggag gatcctagaa acattgtgca
      181 atgaatggtg acacgcgggc cgcagtggtg acctcaccac ctccaaccac agcccctcac
      241 aaggagaggt actttgacag agtcgatgag aacaatccag aatatttgcg ggagaggaac
      301 atggcaccag accttcgtca ggacttcaat atgatggagc agaagaagag ggtgtctatg
      361 attctgcaga gtcccgcctt ctgtgaagag ctggagtcta tgatacagga gcagtttaag
      421 aaggggaaga accctacagg cctgttggca ttacagcaga ttgcggattt catgacggcg
      481 agtgtgccca atgtctaccc ggcagctcca caaggaggaa tggccgccct gaacatgagt
      541 cttggtatgg ttactcctgt gaatgacctt agaggatctg attctattgc atatgacaag
      601 ggggagaagt tactgcgatg taagctggca gcattttaca gactagcaga cctctttggc
      661 tggtctcagc ttatctacaa tcacatcaca accagagtga actctgagca ggagcacttc
      721 ctcatcgtgc ctttcggact tctctacagt gaagtgactg cgtccagcct ggttaaggtc
      781 aatctacaag gagacatagt agaccgcgga agtactaacc tgggagtcaa ccaggccggc
      841 ttcaccttgc actcggccat ttatgctgca cgaccagatg ccaagtgcat tgtgcacatt
      901 cacacaccag caggggctgc ggtctctgca atgaagtgtg ggctcttgcc tatttccccg
      961 gaggcgcttt cccttggaga ggttgcttat catgactatc atggcattct ggttgatgaa
     1021 gaggaaaaaa ttttgattca gaagaatctg ggccctaaaa gcaaggttct cattctccgg
     1081 aatcacgggc tcgtgtcagt tggagagagt gtggaggagg ccttctttta tatccacaac
     1141 cttgtggttg catgtgagat ccaggttcga actctggcaa gtgctggagg accagacaac
     1201 ttagttctgc tggatcctgg gaagtacaaa gccaaatccc gttctccagg gactccagca
     1261 ggggaaggct ctggatcacc tcccaagtgg cagattgggg agcaggaatt tgaagctctt
     1321 atgcggatgc tcgataatct gggctacaga actggctacc cctatcgata ccctgctctg
     1381 agagagagat ctaaaaagta cagcgatgtg gaagtccctg ccagtgtcac cggccactcc
     1441 tttgctagtg acggcgattc gggcacttgc tcgccgctca gacacagttt tcagaagcag
     1501 cagcgagaga agacaagatg gctgaactct ggccggggtg atgacgcttc tgaggagggg
     1561 cagaacggaa gcagtcccaa gtcgaagact aagcctccga atgcttatgc cagctgccct
     1621 ccgcatggac tgttgcattg gactaaagag gatggacata gaacttccac ctctgctgtc
     1681 cctaacctgt ttgttccatt gaacactaac ccaaaagagg tccaggagat gaggaacaag
     1741 attcgagagc agaacttaca ggacattaag acggcaggac ctcagtcgca ggttttgtgt
     1801 ggtgtgatga tggacagaag ccttgtccag gatgcacccc tctctgactg tacggaaact
     1861 atcgaagggc tcgagcgtac agagcagacc tttagtcccg ctaaatctgt ctcttttaga
     1921 aagggggagc tcgtgacggc ctccaaagcc atcattgaga aggaatacca gcctcatgta
     1981 attgtgagca ccacaggtcc caaccccttc aacacgctca cagaccgtga actagaggaa
     2041 taccgccgag aggtggagcg gaagcagaag ggctctgaag agaacctgga cgagacaaga
     2101 gagcagaaag agaagagtcc tccagaccag tcagctgttc ccaacactcc gcccagcact
     2161 cccgtcaagc ttgaaggagg ccttccccag gagccgacat ccagggatgg cagcgatgcc
     2221 accacctcca agccgactcc ccctgacctc tcccctgatg agccttcaga agcacttgcc
     2281 ttcccaacag tggcagagga agcccatgct tccccagaca ccactcagcc ccttgctgag
     2341 gctgaccctg agccagcctc agcctcagct ccaggagctg aagaggtagc ctcccctgcc
     2401 actgaggagg ggtctcccat ggaccctggc agcgatgggt ctccaggcaa gtccccatcc
     2461 aagaagaaga agaagttccg caccccgtcc ttcctgaaga agagcaagaa gaagagtgac
     2521 tcctgaaggc ccaccctgca tactgtcgtg tctgaaggcc tggctctgcc aggactccct
     2581 cctctgtctt gtgttctgtc ctctcgtgta atggaatgca aaaagccaag acctccatgt
     2641 aactagagcc ccctcccatg tatggtcagc ccctgcacca gtgctaaccc agtgtgtgct
     2701 cagcccctct accctgggcc ttgggttctg tggggagttg ggcttagcct gcacctgtga
     2761 gttgtgcccc cctgcaggag ggggacactg aatcctggtc ctggctggaa ggcataggag
     2821 gcttctgcca gctctggtta cagcgtcacc ctcctgagcc ttgcctctca ctctcctttc
     2881 tgtcgtgagt attgaattgt ctgctcagtt tccctccacc ctgtggagtc tcaggtggct
     2941 gatttggact cggctttgct ggcatcctct gctccgtgat gtcagttatc cccatacaca
     3001 ggtatccaca taccccagcc atggtctgag aaaacactct catgtccatc cgcggcccac
     3061 actgtggctg ccttaaagac atgggttaag tctgctgccc tagcagtgag caaccctttg
     3121 tatacccagc acaacgctat gcatggtcta actgatgacc ccatgaccaa aaccacattc
     3181 aggcgctcat agttgacctt accggggtct tgcattccca tcttagggaa cagataccag
     3241 gagggggaag agtcctttct aaaactttgt ttcagcaggt ttgcgattta gcctccattt
     3301 ttactgtgaa cttgaacagg ccactttttg cgttagtttt tgttgtagag cctatgacag
     3361 actgcagcag aacactcttg acttgtgtgg ggaggttttg taggaacagg gaccataact
     3421 cagtctgaac gatgccctgg ttttgatagg gatggtaact catggttgaa gctggctttg
     3481 gaggtgccat ctaatgtctt gcatcattca tggagcccat gaccttcttg gtcatccctt
     3541 atgaattttt acctaacttt tatccctgga aaagggcttg aaactgcttt agtgagtggg
     3601 gaagccgagt gtcaggtgga atcctaaggg gccttgttcc aggagctgcc actgccagcc
     3661 tgactaggag agggagcctg ctggggccct ccacgcccct gctgggttgg gcctcataga
     3721 gcgggtgctc ggatgtggac agaaccctgt gatctcccaa tggggcacca agcaggaccc
     3781 cacagcctgc tgtactgcta gtcccactag tcaccacggt ggcctgagct ctcacctggt
     3841 cctgagtccc ctcatctgga ctcctcctcg tcttccttct ggcccttcct ttatcccaca
     3901 tatgcaatga cttctcactt ttgtagtcta atctttgtat tacacacgga atatcgctgc
     3961 atatatggac agacttggag gacaggtcct gtgtgtcctt tcctcgtcgt aacaggtctt
     4021 actcacaaat aaaagtcttt aagcagtttc tttgtctaa
//
LOCUS       NM_001437203            3269 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 3, mRNA.
ACCESSION   NM_001437203 XM_039091590
VERSION     NM_001437203.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3269)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3269)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3269)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3269)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3269)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3269)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3269)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3269)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_039091590.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.53941.1,
                                           SRR26643293.56320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-351             JAXUCZ010000014.1  21565940-21565975   c
            352-453             JAXUCZ010000014.1  21560488-21560589   c
            454-782             JAXUCZ010000014.1  21559484-21559812   c
            783-1215            JAXUCZ010000014.1  21558937-21559369   c
            1216-1305           JAXUCZ010000014.1  21556341-21556430   c
            1306-1359           JAXUCZ010000014.1  21555834-21555887   c
            1360-1454           JAXUCZ010000014.1  21555171-21555265   c
            1455-1563           JAXUCZ010000014.1  21553803-21553911   c
            1564-1681           JAXUCZ010000014.1  21553603-21553720   c
            1682-1766           JAXUCZ010000014.1  21550070-21550154   c
            1767-1933           JAXUCZ010000014.1  21548930-21549096   c
            1934-2016           JAXUCZ010000014.1  21546400-21546482   c
            2017-2053           JAXUCZ010000014.1  21545168-21545204   c
            2054-2093           JAXUCZ010000014.1  21545032-21545071   c
            2094-2156           JAXUCZ010000014.1  21544877-21544939   c
            2157-2291           JAXUCZ010000014.1  21543336-21543470   c
            2292-3269           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2516
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 3 is encoded by transcript variant 3; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 3"
                     /protein_id="NP_001424132.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKEDCQDCSSWLFSDGELNVLDDILTEVPEQDDELYN
                     PESEQDKNEKKGSKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGK
                     SVTEYKNEEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPT
                     PDGSERIGLEVDRRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEE
                     DVEEDEEVDEDGDDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEG
                     NDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSA
                     SESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVW
                     STLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMS
                     AKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFP
                     PDESIDLYQLIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRI
                     DYPPEFHQRPGYLKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMP
                     PYPGIEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRT
                     QAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRY
                     RR"
     misc_feature    1398..1808
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1398..1808
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     exon            316..351
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            352..453
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            454..782
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1215
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1305
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1359
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1454
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1563
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1681
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1766
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1933
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2016
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2053
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2093
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2156
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2291
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..3269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagaagat tgccaagact gctccagctg gttgttttca gatggggaac
      361 ttaatgtttt agatgatatt ttgactgaag taccagaaca ggatgatgaa ctgtataatc
      421 cagagagtga acaagataaa aatgagaaaa aaggatcaaa aagaaaaagt gaaagaatgg
      481 aatctattga caccaagcga cagaagcctt ctatccattc aagacaactg atttctaagc
      541 cactaagctc atctgttagc aataataaaa gaatagttag tacaaaagga aagtcggtta
      601 cagaatataa aaatgaggaa tatcaaagat ctgaaaggaa caagcgtcta gatgctgatc
      661 gaaaaattcg tctgtcaagc agttcctcta gagaacctta caagagtcaa ccagaaaaac
      721 cttgtctacg gaaaagggat tctgaaagaa gggccaagtc tcctacacca gatggttctg
      781 agagaattgg gcttgaagtt gatagacgtg caagcagatc cagccagtct tcaaaggaag
      841 aggggaactc tgaggagtat ggctctgacc acgagacagg aagcagtgct tcttctgaac
      901 agggcaacaa cactgagaat gaggaggaag gaggggaaga agatgtagag gaagatgaag
      961 aggtagatga agatggagat gatgatgagg aagtggatga agatgcggag gaggaggagg
     1021 acgaggaaga agatgaggag gaggaggatg aggaagaaga agaggaagag gaagaagaat
     1081 atgaacagga tgagagagat cagaaggaag aagggaatga ttatgacacc cgtagtgagg
     1141 ccagtgattc tggttctgag tctgtttcct tcacagatgg atctgtcagg tctggttcag
     1201 gaacagatgg atcagatgag aaaaagaagg aaaggaagag agctcgaggc atatcaccca
     1261 ttgtctttga tagaagtggc agttctgcat cagagtcata tgcaggttca gaaaagaagc
     1321 atgagaaatt atcatcttcc gttcgtgctg tccgaaaaga tcaaaccagt aaactcaaat
     1381 atgtccttca ggatgcaaga tttttcctca taaagagtaa caaccatgag aatgtgtctc
     1441 ttgccaaagc aaagggtgta tggtccacat tacctgtaaa tgagaagaaa ttaaatcttg
     1501 cgtttagatc tgcaaggagt gttatattaa tattttctgt cagggaaagt ggaaagtttc
     1561 aaggttttgc cagattgtca tcagaatcgc atcatggtgg ctctcctata cattgggtgc
     1621 ttccagcagg aatgagtgct aaaatgcttg gaggtgtttt taaaattgac tggatttgca
     1681 ggcgtgaatt accctttact aagtcagctc atctcaccaa tccctggaat gaacataagc
     1741 cagtaaagat tggacgtgat ggacaggaaa ttgaacttga atgtggaacc cagctttgtc
     1801 ttctgtttcc ccctgatgaa agtattgact tgtatcagct cattcataaa atgcgtcaca
     1861 agagaagaat gcattctcag cctcgatcaa gaggacgtcc atcccgtcga gaaccagtcc
     1921 gggatgtggg aaggcgtcga ccagaagatt atgatattca taacagcaga aagaaaccaa
     1981 ggattgacta tccccctgag tttcaccaga gaccagggta tttaaaggat ccccgatacc
     2041 aggaagttga cagacgattt tcaggagttc gccgagatgt gtttttaaat gggtcctaca
     2101 atgattatgt gagggaattt cataacatgg gaccaccgcc tccttggcaa ggaatgcctc
     2161 cttacccggg aatagaacag cctccacacc atccctacta ccagcaccat gccccgcctc
     2221 ctcaagccca ccccccttac tcaggacacc atccggtacc acatgaagca agatacagag
     2281 ataaacgagt acatgactat gatatgaggg ttgatgattt ccttcgccgc acacaagccg
     2341 ttgtcagtgg tcggagaagt agaccccgag aaagagatcg ggagcgagag cgagaccgcc
     2401 ctagagataa cagaagagat agagagcgag acagaggtcg tgatcgagaa agagagagag
     2461 aaagaatatg tgatcgggac agagaccgag gggaaagagg tcgttatcga agataatgtg
     2521 ctttttggaa gcactgactg aagataaaaa atattgtatt ttttttgtgt gtgtttacaa
     2581 gtagtaaatt tattttcagc tgtctactta aagctcattg tgtagaagga tttattatct
     2641 tctttgttcc aagcatgcag tagaataaga actggaaaac tcagatccgc caaaaaatgc
     2701 acagttgaca gttgagttga cacttttatt ggggcagaat ggaacagtcc aagaatgtag
     2761 atattgattc attctccata aatgttcttt ttacagtgta ttcatcctag agttattttg
     2821 tttgtttgtt ttccttcttt tggaccttgg tcaatactgc catagtattt tgctttgtgt
     2881 ttctataggt agctgcacac ggttcagtaa aaataatgct gctatcaagt atgcagatat
     2941 tgagtatgat ggtttgacta tatggcagtg ttgtagcagc ctctcggttt ctcctcttcc
     3001 ctcctttttt ttaaacctat aaatccactt tttttttaag tcttcaatga tgagagcaat
     3061 attaagaaga cattgctatc taatttttaa tctttttaaa taaaacgttc ctatgttcag
     3121 tagcatggtc gatgctattg tttagccttc cttccaaact gtacattggc ttggaatgtt
     3181 cagttttgcg tgtgtggcag cagaagataa ccccacattc tacattgcta ctgttttgta
     3241 tgaaataaat tggtaaagat tgacactaa
//
LOCUS       NM_001437206            3203 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 6, mRNA.
ACCESSION   NM_001437206 XM_063272837
VERSION     NM_001437206.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3203)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3203)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3203)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_063272837.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.53944.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-417             JAXUCZ010000014.1  21560488-21560589   c
            418-746             JAXUCZ010000014.1  21559484-21559812   c
            747-1179            JAXUCZ010000014.1  21558937-21559369   c
            1180-1269           JAXUCZ010000014.1  21556341-21556430   c
            1270-1364           JAXUCZ010000014.1  21555171-21555265   c
            1365-1473           JAXUCZ010000014.1  21553803-21553911   c
            1474-1591           JAXUCZ010000014.1  21553603-21553720   c
            1592-1676           JAXUCZ010000014.1  21550070-21550154   c
            1677-1843           JAXUCZ010000014.1  21548930-21549096   c
            1844-1926           JAXUCZ010000014.1  21546400-21546482   c
            1927-1963           JAXUCZ010000014.1  21545168-21545204   c
            1964-2027           JAXUCZ010000014.1  21545032-21545095   c
            2028-2090           JAXUCZ010000014.1  21544877-21544939   c
            2091-2225           JAXUCZ010000014.1  21543336-21543470   c
            2226-3203           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3203
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2450
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 6 is encoded by transcript variant 6; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 6"
                     /protein_id="NP_001424135.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQR
                     SERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDG
                     DDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDS
                     GSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYADQTSKLK
                     YVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESG
                     KFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPW
                     NEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKRRMHSQPRSRGRP
                     SRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDSFTNLIPN
                     RRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHPYYQHHAPPPQ
                     AHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDR
                     PRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR"
     misc_feature    1308..1718
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1308..1718
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     exon            316..417
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            418..746
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1364
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1473
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1591
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1676
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1843
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1926
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..1963
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2027
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2090
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2225
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..3203
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagatggg gaacttaatg ttttagatga tattttgact gaagtaccag
      361 aacaggatga tgaactgtat aatccagaga gtgaacaaga taaaaatgag aaaaaaggat
      421 caaaaagaaa aagtgaaaga atggaatcta ttgacaccaa gcgacagaag ccttctatcc
      481 attcaagaca actgatttct aagccactaa gctcatctgt tagcaataat aaaagaatag
      541 ttagtacaaa aggaaagtcg gttacagaat ataaaaatga ggaatatcaa agatctgaaa
      601 ggaacaagcg tctagatgct gatcgaaaaa ttcgtctgtc aagcagttcc tctagagaac
      661 cttacaagag tcaaccagaa aaaccttgtc tacggaaaag ggattctgaa agaagggcca
      721 agtctcctac accagatggt tctgagagaa ttgggcttga agttgataga cgtgcaagca
      781 gatccagcca gtcttcaaag gaagagggga actctgagga gtatggctct gaccacgaga
      841 caggaagcag tgcttcttct gaacagggca acaacactga gaatgaggag gaaggagggg
      901 aagaagatgt agaggaagat gaagaggtag atgaagatgg agatgatgat gaggaagtgg
      961 atgaagatgc ggaggaggag gaggacgagg aagaagatga ggaggaggag gatgaggaag
     1021 aagaagagga agaggaagaa gaatatgaac aggatgagag agatcagaag gaagaaggga
     1081 atgattatga cacccgtagt gaggccagtg attctggttc tgagtctgtt tccttcacag
     1141 atggatctgt caggtctggt tcaggaacag atggatcaga tgagaaaaag aaggaaagga
     1201 agagagctcg aggcatatca cccattgtct ttgatagaag tggcagttct gcatcagagt
     1261 catatgcaga tcaaaccagt aaactcaaat atgtccttca ggatgcaaga tttttcctca
     1321 taaagagtaa caaccatgag aatgtgtctc ttgccaaagc aaagggtgta tggtccacat
     1381 tacctgtaaa tgagaagaaa ttaaatcttg cgtttagatc tgcaaggagt gttatattaa
     1441 tattttctgt cagggaaagt ggaaagtttc aaggttttgc cagattgtca tcagaatcgc
     1501 atcatggtgg ctctcctata cattgggtgc ttccagcagg aatgagtgct aaaatgcttg
     1561 gaggtgtttt taaaattgac tggatttgca ggcgtgaatt accctttact aagtcagctc
     1621 atctcaccaa tccctggaat gaacataagc cagtaaagat tggacgtgat ggacaggaaa
     1681 ttgaacttga atgtggaacc cagctttgtc ttctgtttcc ccctgatgaa agtattgact
     1741 tgtatcagct cattcataaa atgcgtcaca agagaagaat gcattctcag cctcgatcaa
     1801 gaggacgtcc atcccgtcga gaaccagtcc gggatgtggg aaggcgtcga ccagaagatt
     1861 atgatattca taacagcaga aagaaaccaa ggattgacta tccccctgag tttcaccaga
     1921 gaccagggta tttaaaggat ccccgatacc aggaagttga cagtttcaca aatcttattc
     1981 ccaacagacg attttcagga gttcgccgag atgtgttttt aaatgggtcc tacaatgatt
     2041 atgtgaggga atttcataac atgggaccac cgcctccttg gcaaggaatg cctccttacc
     2101 cgggaataga acagcctcca caccatccct actaccagca ccatgccccg cctcctcaag
     2161 cccacccccc ttactcagga caccatccgg taccacatga agcaagatac agagataaac
     2221 gagtacatga ctatgatatg agggttgatg atttccttcg ccgcacacaa gccgttgtca
     2281 gtggtcggag aagtagaccc cgagaaagag atcgggagcg agagcgagac cgccctagag
     2341 ataacagaag agatagagag cgagacagag gtcgtgatcg agaaagagag agagaaagaa
     2401 tatgtgatcg ggacagagac cgaggggaaa gaggtcgtta tcgaagataa tgtgcttttt
     2461 ggaagcactg actgaagata aaaaatattg tatttttttt gtgtgtgttt acaagtagta
     2521 aatttatttt cagctgtcta cttaaagctc attgtgtaga aggatttatt atcttctttg
     2581 ttccaagcat gcagtagaat aagaactgga aaactcagat ccgccaaaaa atgcacagtt
     2641 gacagttgag ttgacacttt tattggggca gaatggaaca gtccaagaat gtagatattg
     2701 attcattctc cataaatgtt ctttttacag tgtattcatc ctagagttat tttgtttgtt
     2761 tgttttcctt cttttggacc ttggtcaata ctgccatagt attttgcttt gtgtttctat
     2821 aggtagctgc acacggttca gtaaaaataa tgctgctatc aagtatgcag atattgagta
     2881 tgatggtttg actatatggc agtgttgtag cagcctctcg gtttctcctc ttccctcctt
     2941 ttttttaaac ctataaatcc actttttttt taagtcttca atgatgagag caatattaag
     3001 aagacattgc tatctaattt ttaatctttt taaataaaac gttcctatgt tcagtagcat
     3061 ggtcgatgct attgtttagc cttccttcca aactgtacat tggcttggaa tgttcagttt
     3121 tgcgtgtgtg gcagcagaag ataaccccac attctacatt gctactgttt tgtatgaaat
     3181 aaattggtaa agattgacac taa
//
LOCUS       NM_001437176            2040 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 13, mRNA.
ACCESSION   NM_001437176
VERSION     NM_001437176.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54676.1,
                                           SRR26360186.844327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-315             JAXUCZ010000018.1  69732881-69732980
            316-462             JAXUCZ010000018.1  69735312-69735458
            463-645             JAXUCZ010000018.1  69736744-69736926
            646-756             JAXUCZ010000018.1  69740890-69741000
            757-864             JAXUCZ010000018.1  69741592-69741699
            865-2040            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2040
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            216..315
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..918
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 7 is encoded by transcript variant 13;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 7"
                     /protein_id="NP_001424105.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVS
                     SEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDLAAFAGRKWKKFFTHQVN
                     QTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHY
                     HPEILLFFYANKIL"
     exon            316..462
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            463..645
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            646..756
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            757..864
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            865..2040
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccagtttca tggaacaaat gcagagaatc
      241 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      301 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      361 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      421 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca aggtgagaaa gtataagaaa
      481 gttatgcttg acctgctggt acacgggctg tatgatcctg tgagttccga agtcattcat
      541 gagagtgtga agacgctgac tatcatgttg ggcaagatcc agggccaacg gctgggctcc
      601 ttcttcatag acatcaccct tcagacccgg accctattgg atgatttggc tgcatttgct
      661 gggcggaaat ggaagaagtt cttcacccac caggtcaacc agacccaaga ttccctccta
      721 agccatttgc aggacgaaag ccctcaggtt gccaaggctt gcacaatggc tgttcaagcc
      781 tgtgttccat acctgaaacc cagaaaggag cagagtttcc aaagtgaaga agaccagaag
      841 aaccgcaggc tttcccagca actgagccac taccatccag agatcctgct gttcttctat
      901 gccaataaaa tcctgtaggt ccagagcagc agagaaagcc cacgggagtg ccctgccccg
      961 gcatggaatt tcccatctgt ctcataggat acctctttga ctctcgagtg attgtaagag
     1021 aaaagaggat gtcagagagc aactgaaaaa aaaatcaccc tggagtgcac gcaaagtaaa
     1081 attctatgca agtgtgtgca catacatgca catgactgtg gaggtcagag gacgacctca
     1141 ctgctgttcc taaggcgtca tccatctttc cactgaaaca ggatctttga ctggcctggg
     1201 gcttgcagga gcttagacta ggcttgatag ctagtgagcc agctctgggg ttataaccac
     1261 agtccatcga accaaccgtt tttgactgtg ccaaattcag gcccttatac ctacttgtgc
     1321 tgactaagcc gtctccccag cccagtagat gcacacttcc ttaaaacatt taacatgcat
     1381 gatgtcccaa tccctccttt ctcactccct ctctgccagg tgacacacat ttataatatg
     1441 taacttctga ggcttggggg aacaattgtt accttaaaca tttttaaact gtatttgttt
     1501 ttgatagttt gctatttgct acggaccagg agaccaagga gctggcttac aatgtgtctt
     1561 taatttcgga tgatcttaaa atgtcatggt cttaaaatcg tctttaaaaa gaacaacaag
     1621 gaaaagaaat attgttgaaa atccactgaa tgatgataag ttacagaata aaaacagtaa
     1681 catttactga gaatgcttac aacttatttc ggtactgtgg tggtttggat gagcgaccct
     1741 gcaggcttac gtatttgaat gcttggtccc ttcttagtgg aagtgtttag gaggggttag
     1801 agggtgtgta tatcactgga gatggaattt gagacttcag aagcccaagc aaggccctgt
     1861 ctgtctgtct gtctgtctgt ctgtccgtct cttattttgc ctgcctactg tctacagatc
     1921 aagacgtaaa gctctcagtt actactctag caccatgcct gtctactcct accatgatga
     1981 taatgaactg gccttctaaa actctaagcc agccccaatt aaacgcttcc ttttataaga
//
LOCUS       NM_001008295            4542 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 1, mRNA.
ACCESSION   NM_001008295 XM_214044
VERSION     NM_001008295.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4542)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4542)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4542)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4542)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4542)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4542)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4542)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4542)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced NM_001008295.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.46591.1, BC085767.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-945             JAXUCZ010000014.1  34009985-34010094   c
            946-1039            JAXUCZ010000014.1  33995782-33995875   c
            1040-1196           JAXUCZ010000014.1  33994406-33994562   c
            1197-1251           JAXUCZ010000014.1  33981524-33981578   c
            1252-1307           JAXUCZ010000014.1  33980419-33980474   c
            1308-1527           JAXUCZ010000014.1  33976291-33976510   c
            1528-1665           JAXUCZ010000014.1  33972832-33972969   c
            1666-4542           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4542
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..1813
                     /gene="Fip1l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     1"
                     /protein_id="NP_001008296.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTG
                     NSEKEAALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENS
                     NIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFP
                     PPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWPSLVDTTKQWD
                     YYARREKDRDRDRERDRDRERERDRDRERERTRERERERDHSPTPSVFNSDEERYRYR
                     EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHK
                     KSKRSKEGKEAGSEPVPEQESTEAAPAE"
     misc_feature    203..1090
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Necessary for stimulating PAPOLA activity.
                     /evidence=ECO:0000250"
     misc_feature    203..532
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with PAPOLA.
                     /evidence=ECO:0000250"
     misc_feature    203..487
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    452..454
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D824; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    458..460
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D824; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    464..466
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    608..859
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with CPSF4.
                     /evidence=ECO:0000250"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    836..940
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1100..1810
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1298..1300
                     /gene="Fip1l1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1349..1810
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with CPSF1 and CSTF3.
                     /evidence=ECO:0000250"
     misc_feature    1391..1498
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Arg/Asp/Glu-rich domain.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15"
     misc_feature    1502..1504
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1508..1510
                     /gene="Fip1l1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1514..1516
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1526..1528
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1688..1690
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..945
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1039
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1196
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1251
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1307
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1527
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1665
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..4542
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggtaca
      841 gcaagggaga actggaaatt cagagaaaga agcagcactt ccatctacaa aagctgagtt
      901 tacttctccg ccatcattgt tcaagactgg tctgccacca agcaggagat tacctggagc
      961 aatcgatgtc attggtcaaa caataaccat cagccgagta gaaggaagac ggcgtgcaaa
     1021 tgagaacagc aatatacagg ttctttctga cagatctgcc actgaagtag acaacaattt
     1081 cagcaaacca cctccatttt tccctccagg ggctcctcct actcaccttc ctcctcctcc
     1141 atttcttcca cctcctccaa ctgtcagcac tgctccacct ttgattccac caccaggttt
     1201 cccccctcca ccaggcgctc cacctccatc tcttataccg acaatagaaa gtggccattc
     1261 ctctggttac gacagccgtt ctgcacgggc gtttccatat ggcaatgttg cctttcccca
     1321 ccttaccagt tccgctccct catggcctag ccttgtggat accactaagc agtgggacta
     1381 ttatgcacgg agagaaaaag atcgagatcg agaccgagag agagaccgag acagagaaag
     1441 ggagagagac cgggacagag aaagggagcg cacccgggag cgagagcggg agcgggacca
     1501 cagccccacc ccaagtgttt tcaacagtga tgaagagcga tacagataca gggagtatgc
     1561 agagagaggc tatgagcgcc acagagctag tcgggagaaa gaagagcggc acagagaacg
     1621 acggcacaga gagaaggagg aaacaagaca caagtcctct cgcagtaata gtagacgtcg
     1681 tcatgaaagt gaagaagggg acagtcacag aagacacaag cacaaaaagt ctaaaaggag
     1741 caaagaagga aaagaggctg gcagcgagcc ggtccctgag caggagagca cggaagctgc
     1801 ccctgccgag taggcgccac ctcttatgta cgtcagcccc agaaatagat gctataaatc
     1861 tccttatttt tctggataat gtttaagaaa tgtaccttta atcttgttct gttagaatga
     1921 aacgttaact ttttcttttc caaaataaaa gtgtgcattt ttttgtgtta agttaaaaat
     1981 ctttgtcttg taatatttaa agaataaaag acaaaaatta ctttatatct aagaaagtaa
     2041 tgtgaataag tcagcagggg acttagtgct aagttggccg tgtgtgcagt gtggtgagga
     2101 tcaaggactc actagctttc tagtgagcgg gacgctgtcg gcaggagagg tgctgtggtg
     2161 cagaagcccc tctcatgtga cgtcaggctt cctcttactg ctgtcacact cctgcatctt
     2221 taagaacttg gacacattct tgttatcaca gttttgatag caggttttca gtggtccata
     2281 gtaactaaat ggactgtttg aatctctgac tttagagatg gtctgaggca cttgggtggc
     2341 cctatgatgg aacttgtgtg cttcccagca ggcacatgga ctggcacagc gtcaaaccac
     2401 ttcatggcca tctgtttgaa caagggtcaa gggcttcagc tgctgctaac gtgttttcca
     2461 aggctcattg gtagcataga acgtggggta ttttttgtaa taccaggtcc atattaataa
     2521 aaaataaact cagtgagagt agtgtcagat cagtcattct tactaaaacc agaactccag
     2581 gttaaaatct ggactaaccc caagaaggtt ccagagcagc ggtggggctg ggaatgtgtg
     2641 tgaaaggacg aggcagttag agccaccagt aagaggactg cggtcactta gaagaagata
     2701 ttcatctctt gttcaaatcc tccgccatta aactgaaatg gccataatgt gctgtgtctt
     2761 caactccact tctaccacat ttgacgttgc cttgaattaa gtgtggcata caaaccatgt
     2821 aagtttttat gggcttttta ttgaattaaa aaaatagaaa cttaaaagat ttggagtgat
     2881 gagaaatcct ccacaccaaa taaaaattaa cattagtttt tatttttgag aacattctct
     2941 gatgtgtaac ttgttttcat aagtcatact ttttctggct tttttttttt acaatatatt
     3001 ctttaaatat aaaaatcgac aagataaata caattttatc tagcctattt gtggtttttc
     3061 taagatccat cattggtttt ataaaaaagt accaggccag gaagcaatgg tgagagtaat
     3121 tttccctttg agttctttga gcatcctcgc taagcaggcg tgcatcatcc ccgacgtgct
     3181 tctgccgttg acagcaagaa gaatgtcacc acatctgaaa agatacggca ttgtgatcag
     3241 aactgcttca agcctgaagc gcctcaaagt ggacttgggt ggccctaggg ctgccatatt
     3301 tgtccttttt agttctgatt tgatttccct cttcccataa attctccaag ctccacgcag
     3361 cgtgcatcaa aggtatagga aattgcaagg tgggaccaag gccggttcta gttttggatt
     3421 tctctctacc tagctagtgc tctcgtgtct taatttctca ctctttagga aagtataagc
     3481 tgcgctttct tccaagtggg gccaagtttt acatgtagaa agcaaaatac ttgaatatta
     3541 gttttctgag taatcattac ctaattcttc catcattata cgcgggtgtt ccctcgacga
     3601 tggatttgat aaaaaaaggt tggttaccac tgtattcttc ataacctccc acaatgcaga
     3661 agcccaggct tcccgctgtg ttccttcgta gtatcacatc cttacagtta tataagtacc
     3721 tgaaacagaa tgtaattagt ggatgtacag ttgagtttac tagttgtgac tcctttcatt
     3781 catttttttg ggggacactt ttaaaatgaa aaatactgca tatgtctcca tcagaagtga
     3841 cagcaacttt ttatgctctt agtcagcttt tgcatttgat ctctcttttc catagccaaa
     3901 taccctttca acaaaaggag ttagtattat gttctattca tgtctctgct gagaaaaatg
     3961 gccacatatt ttggttaagg cgcagtaatg aatgcatgag ccaaaagttg gatgtgtctc
     4021 agtacttctt attccccaca gtagaacata ctgagggaat atcattttta tattcttggg
     4081 ggcttacata atttgtaaag aagacaaaca ttctctgaat tagcgattaa tcgcaaggac
     4141 aataatttta acttatgcta atgaacttat actcacacag acttagagaa gactagagaa
     4201 agtgaatgga aattgggcca taaaatagtg gagcagttgt cggacagtaa gtggcatagc
     4261 tgaagcagtc aggggaaggg aaggagcaca gctggcctga gagccagtac agccttcagc
     4321 tgggatagcc gcggctaagt gtgagcagct gcactacagt agactgtcgg aagatggggt
     4381 cgctctggga ccccttgtct gccgcatgtg tctaggaact gcttttgact ggaagatagt
     4441 attttttgtt gttagaattg aagatgtctt gtttatagac tgtaccttaa aataatcagt
     4501 tgctttttga taatcaataa aaatgatctt gtgaaatatt aa
//
LOCUS       NM_001437207            3179 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 7, mRNA.
ACCESSION   NM_001437207 XM_006250808
VERSION     NM_001437207.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3179)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3179)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3179)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3179)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3179)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3179)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250808.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78303.1, SRR26643298.53947.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-417             JAXUCZ010000014.1  21560488-21560589   c
            418-746             JAXUCZ010000014.1  21559484-21559812   c
            747-1179            JAXUCZ010000014.1  21558937-21559369   c
            1180-1269           JAXUCZ010000014.1  21556341-21556430   c
            1270-1364           JAXUCZ010000014.1  21555171-21555265   c
            1365-1473           JAXUCZ010000014.1  21553803-21553911   c
            1474-1591           JAXUCZ010000014.1  21553603-21553720   c
            1592-1676           JAXUCZ010000014.1  21550070-21550154   c
            1677-1843           JAXUCZ010000014.1  21548930-21549096   c
            1844-1926           JAXUCZ010000014.1  21546400-21546482   c
            1927-1963           JAXUCZ010000014.1  21545168-21545204   c
            1964-2003           JAXUCZ010000014.1  21545032-21545071   c
            2004-2066           JAXUCZ010000014.1  21544877-21544939   c
            2067-2201           JAXUCZ010000014.1  21543336-21543470   c
            2202-3179           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2426
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 7 is encoded by transcript variant 7; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 7"
                     /protein_id="NP_001424136.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQR
                     SERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDG
                     DDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDS
                     GSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYADQTSKLK
                     YVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESG
                     KFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPW
                     NEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKRRMHSQPRSRGRP
                     SRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDRRFSGVRR
                     DVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHPYYQHHAPPPQAHPPYSGH
                     HPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDR
                     ERDRGRDRERERERICDRDRDRGERGRYRR"
     misc_feature    1308..1718
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1308..1718
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     exon            316..417
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            418..746
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1364
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1473
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1591
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1676
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1843
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1926
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..1963
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2003
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2066
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2201
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..3179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagatggg gaacttaatg ttttagatga tattttgact gaagtaccag
      361 aacaggatga tgaactgtat aatccagaga gtgaacaaga taaaaatgag aaaaaaggat
      421 caaaaagaaa aagtgaaaga atggaatcta ttgacaccaa gcgacagaag ccttctatcc
      481 attcaagaca actgatttct aagccactaa gctcatctgt tagcaataat aaaagaatag
      541 ttagtacaaa aggaaagtcg gttacagaat ataaaaatga ggaatatcaa agatctgaaa
      601 ggaacaagcg tctagatgct gatcgaaaaa ttcgtctgtc aagcagttcc tctagagaac
      661 cttacaagag tcaaccagaa aaaccttgtc tacggaaaag ggattctgaa agaagggcca
      721 agtctcctac accagatggt tctgagagaa ttgggcttga agttgataga cgtgcaagca
      781 gatccagcca gtcttcaaag gaagagggga actctgagga gtatggctct gaccacgaga
      841 caggaagcag tgcttcttct gaacagggca acaacactga gaatgaggag gaaggagggg
      901 aagaagatgt agaggaagat gaagaggtag atgaagatgg agatgatgat gaggaagtgg
      961 atgaagatgc ggaggaggag gaggacgagg aagaagatga ggaggaggag gatgaggaag
     1021 aagaagagga agaggaagaa gaatatgaac aggatgagag agatcagaag gaagaaggga
     1081 atgattatga cacccgtagt gaggccagtg attctggttc tgagtctgtt tccttcacag
     1141 atggatctgt caggtctggt tcaggaacag atggatcaga tgagaaaaag aaggaaagga
     1201 agagagctcg aggcatatca cccattgtct ttgatagaag tggcagttct gcatcagagt
     1261 catatgcaga tcaaaccagt aaactcaaat atgtccttca ggatgcaaga tttttcctca
     1321 taaagagtaa caaccatgag aatgtgtctc ttgccaaagc aaagggtgta tggtccacat
     1381 tacctgtaaa tgagaagaaa ttaaatcttg cgtttagatc tgcaaggagt gttatattaa
     1441 tattttctgt cagggaaagt ggaaagtttc aaggttttgc cagattgtca tcagaatcgc
     1501 atcatggtgg ctctcctata cattgggtgc ttccagcagg aatgagtgct aaaatgcttg
     1561 gaggtgtttt taaaattgac tggatttgca ggcgtgaatt accctttact aagtcagctc
     1621 atctcaccaa tccctggaat gaacataagc cagtaaagat tggacgtgat ggacaggaaa
     1681 ttgaacttga atgtggaacc cagctttgtc ttctgtttcc ccctgatgaa agtattgact
     1741 tgtatcagct cattcataaa atgcgtcaca agagaagaat gcattctcag cctcgatcaa
     1801 gaggacgtcc atcccgtcga gaaccagtcc gggatgtggg aaggcgtcga ccagaagatt
     1861 atgatattca taacagcaga aagaaaccaa ggattgacta tccccctgag tttcaccaga
     1921 gaccagggta tttaaaggat ccccgatacc aggaagttga cagacgattt tcaggagttc
     1981 gccgagatgt gtttttaaat gggtcctaca atgattatgt gagggaattt cataacatgg
     2041 gaccaccgcc tccttggcaa ggaatgcctc cttacccggg aatagaacag cctccacacc
     2101 atccctacta ccagcaccat gccccgcctc ctcaagccca ccccccttac tcaggacacc
     2161 atccggtacc acatgaagca agatacagag ataaacgagt acatgactat gatatgaggg
     2221 ttgatgattt ccttcgccgc acacaagccg ttgtcagtgg tcggagaagt agaccccgag
     2281 aaagagatcg ggagcgagag cgagaccgcc ctagagataa cagaagagat agagagcgag
     2341 acagaggtcg tgatcgagaa agagagagag aaagaatatg tgatcgggac agagaccgag
     2401 gggaaagagg tcgttatcga agataatgtg ctttttggaa gcactgactg aagataaaaa
     2461 atattgtatt ttttttgtgt gtgtttacaa gtagtaaatt tattttcagc tgtctactta
     2521 aagctcattg tgtagaagga tttattatct tctttgttcc aagcatgcag tagaataaga
     2581 actggaaaac tcagatccgc caaaaaatgc acagttgaca gttgagttga cacttttatt
     2641 ggggcagaat ggaacagtcc aagaatgtag atattgattc attctccata aatgttcttt
     2701 ttacagtgta ttcatcctag agttattttg tttgtttgtt ttccttcttt tggaccttgg
     2761 tcaatactgc catagtattt tgctttgtgt ttctataggt agctgcacac ggttcagtaa
     2821 aaataatgct gctatcaagt atgcagatat tgagtatgat ggtttgacta tatggcagtg
     2881 ttgtagcagc ctctcggttt ctcctcttcc ctcctttttt ttaaacctat aaatccactt
     2941 tttttttaag tcttcaatga tgagagcaat attaagaaga cattgctatc taatttttaa
     3001 tctttttaaa taaaacgttc ctatgttcag tagcatggtc gatgctattg tttagccttc
     3061 cttccaaact gtacattggc ttggaatgtt cagttttgcg tgtgtggcag cagaagataa
     3121 ccccacattc tacattgcta ctgttttgta tgaaataaat tggtaaagat tgacactaa
//
LOCUS       NM_001437180            1838 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 17, mRNA.
ACCESSION   NM_001437180
VERSION     NM_001437180.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54678.1,
                                           SRR26360186.1889133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-398             JAXUCZ010000018.1  69736744-69736926
            399-554             JAXUCZ010000018.1  69740845-69741000
            555-662             JAXUCZ010000018.1  69741592-69741699
            663-1838            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..1838
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            216..398
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..716
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 9 is encoded by transcript variant 17;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 9"
                     /protein_id="NP_001424109.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQGQRLGSFFIDI
                     TLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQDSLLSHLQDESP
                     QVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     exon            399..554
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            555..662
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            663..1838
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccaggtgag aaagtataag aaagttatgc
      241 ttgacctgct ggtacacggg ctgtatgatc ctgtgagttc cgaagtcatt catgagagtg
      301 tgaagacgct gactatcatg ttgggcaaga tccagggcca acggctgggc tccttcttca
      361 tagacatcac ccttcagacc cggaccctat tggatgatga ggatgacagc gtgcgctact
      421 cagcctttgt cctctttggg cagttggctg catttgctgg gcggaaatgg aagaagttct
      481 tcacccacca ggtcaaccag acccaagatt ccctcctaag ccatttgcag gacgaaagcc
      541 ctcaggttgc caaggcttgc acaatggctg ttcaagcctg tgttccatac ctgaaaccca
      601 gaaaggagca gagtttccaa agtgaagaag accagaagaa ccgcaggctt tcccagcaac
      661 tgagccacta ccatccagag atcctgctgt tcttctatgc caataaaatc ctgtaggtcc
      721 agagcagcag agaaagccca cgggagtgcc ctgccccggc atggaatttc ccatctgtct
      781 cataggatac ctctttgact ctcgagtgat tgtaagagaa aagaggatgt cagagagcaa
      841 ctgaaaaaaa aatcaccctg gagtgcacgc aaagtaaaat tctatgcaag tgtgtgcaca
      901 tacatgcaca tgactgtgga ggtcagagga cgacctcact gctgttccta aggcgtcatc
      961 catctttcca ctgaaacagg atctttgact ggcctggggc ttgcaggagc ttagactagg
     1021 cttgatagct agtgagccag ctctggggtt ataaccacag tccatcgaac caaccgtttt
     1081 tgactgtgcc aaattcaggc ccttatacct acttgtgctg actaagccgt ctccccagcc
     1141 cagtagatgc acacttcctt aaaacattta acatgcatga tgtcccaatc cctcctttct
     1201 cactccctct ctgccaggtg acacacattt ataatatgta acttctgagg cttgggggaa
     1261 caattgttac cttaaacatt tttaaactgt atttgttttt gatagtttgc tatttgctac
     1321 ggaccaggag accaaggagc tggcttacaa tgtgtcttta atttcggatg atcttaaaat
     1381 gtcatggtct taaaatcgtc tttaaaaaga acaacaagga aaagaaatat tgttgaaaat
     1441 ccactgaatg atgataagtt acagaataaa aacagtaaca tttactgaga atgcttacaa
     1501 cttatttcgg tactgtggtg gtttggatga gcgaccctgc aggcttacgt atttgaatgc
     1561 ttggtccctt cttagtggaa gtgtttagga ggggttagag ggtgtgtata tcactggaga
     1621 tggaatttga gacttcagaa gcccaagcaa ggccctgtct gtctgtctgt ctgtctgtct
     1681 gtccgtctct tattttgcct gcctactgtc tacagatcaa gacgtaaagc tctcagttac
     1741 tactctagca ccatgcctgt ctactcctac catgatgata atgaactggc cttctaaaac
     1801 tctaagccag ccccaattaa acgcttcctt ttataaga
//
LOCUS       NM_001437213            4638 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 4, mRNA.
ACCESSION   NM_001437213 XM_006250885
VERSION     NM_001437213.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4638)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4638)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4638)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4638)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4638)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4638)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250885.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.48778.1,
                                           SRR26360194.2246078.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-904             JAXUCZ010000014.1  34017713-34017781   c
            905-1014            JAXUCZ010000014.1  34009985-34010094   c
            1015-1108           JAXUCZ010000014.1  33995782-33995875   c
            1109-1265           JAXUCZ010000014.1  33994406-33994562   c
            1266-1292           JAXUCZ010000014.1  33983462-33983488   c
            1293-1347           JAXUCZ010000014.1  33981524-33981578   c
            1348-1403           JAXUCZ010000014.1  33980419-33980474   c
            1404-1623           JAXUCZ010000014.1  33976291-33976510   c
            1624-1761           JAXUCZ010000014.1  33972832-33972969   c
            1762-4638           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4638
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..1909
                     /gene="Fip1l1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     4"
                     /protein_id="NP_001424142.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTME
                     VTPGAEIQDGRFNLFKVQQGRTGNSEKEAALPSTKAEFTSPPSLFKTGLPPSRRLPGA
                     IDVIGQTITISRVEGRRRANENSNIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPP
                     PPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRS
                     ARAFPYGNVAFPHLTSSAPSWPSLVDTTKQWDYYARREKDRDRDRERDRDRERERDRD
                     RERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHR
                     EKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPVPEQESTEAAP
                     AE"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..904
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1014
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1108
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1265
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1292
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1347
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1403
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1623
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1761
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..4638
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggccga
      841 agactgtact atggaagtca caccaggtgc agagatccaa gatggcagat tcaatctttt
      901 taaggtacag caagggagaa ctggaaattc agagaaagaa gcagcacttc catctacaaa
      961 agctgagttt acttctccgc catcattgtt caagactggt ctgccaccaa gcaggagatt
     1021 acctggagca atcgatgtca ttggtcaaac aataaccatc agccgagtag aaggaagacg
     1081 gcgtgcaaat gagaacagca atatacaggt tctttctgac agatctgcca ctgaagtaga
     1141 caacaatttc agcaaaccac ctccattttt ccctccaggg gctcctccta ctcaccttcc
     1201 tcctcctcca tttcttccac ctcctccaac tgtcagcact gctccacctt tgattccacc
     1261 accaggtatt ccaataactg taccacctcc aggtttcccc cctccaccag gcgctccacc
     1321 tccatctctt ataccgacaa tagaaagtgg ccattcctct ggttacgaca gccgttctgc
     1381 acgggcgttt ccatatggca atgttgcctt tccccacctt accagttccg ctccctcatg
     1441 gcctagcctt gtggatacca ctaagcagtg ggactattat gcacggagag aaaaagatcg
     1501 agatcgagac cgagagagag accgagacag agaaagggag agagaccggg acagagaaag
     1561 ggagcgcacc cgggagcgag agcgggagcg ggaccacagc cccaccccaa gtgttttcaa
     1621 cagtgatgaa gagcgataca gatacaggga gtatgcagag agaggctatg agcgccacag
     1681 agctagtcgg gagaaagaag agcggcacag agaacgacgg cacagagaga aggaggaaac
     1741 aagacacaag tcctctcgca gtaatagtag acgtcgtcat gaaagtgaag aaggggacag
     1801 tcacagaaga cacaagcaca aaaagtctaa aaggagcaaa gaaggaaaag aggctggcag
     1861 cgagccggtc cctgagcagg agagcacgga agctgcccct gccgagtagg cgccacctct
     1921 tatgtacgtc agccccagaa atagatgcta taaatctcct tatttttctg gataatgttt
     1981 aagaaatgta cctttaatct tgttctgtta gaatgaaacg ttaacttttt cttttccaaa
     2041 ataaaagtgt gcattttttt gtgttaagtt aaaaatcttt gtcttgtaat atttaaagaa
     2101 taaaagacaa aaattacttt atatctaaga aagtaatgtg aataagtcag caggggactt
     2161 agtgctaagt tggccgtgtg tgcagtgtgg tgaggatcaa ggactcacta gctttctagt
     2221 gagcgggacg ctgtcggcag gagaggtgct gtggtgcaga agcccctctc atgtgacgtc
     2281 aggcttcctc ttactgctgt cacactcctg catctttaag aacttggaca cattcttgtt
     2341 atcacagttt tgatagcagg ttttcagtgg tccatagtaa ctaaatggac tgtttgaatc
     2401 tctgacttta gagatggtct gaggcacttg ggtggcccta tgatggaact tgtgtgcttc
     2461 ccagcaggca catggactgg cacagcgtca aaccacttca tggccatctg tttgaacaag
     2521 ggtcaagggc ttcagctgct gctaacgtgt tttccaaggc tcattggtag catagaacgt
     2581 ggggtatttt ttgtaatacc aggtccatat taataaaaaa taaactcagt gagagtagtg
     2641 tcagatcagt cattcttact aaaaccagaa ctccaggtta aaatctggac taaccccaag
     2701 aaggttccag agcagcggtg gggctgggaa tgtgtgtgaa aggacgaggc agttagagcc
     2761 accagtaaga ggactgcggt cacttagaag aagatattca tctcttgttc aaatcctccg
     2821 ccattaaact gaaatggcca taatgtgctg tgtcttcaac tccacttcta ccacatttga
     2881 cgttgccttg aattaagtgt ggcatacaaa ccatgtaagt ttttatgggc tttttattga
     2941 attaaaaaaa tagaaactta aaagatttgg agtgatgaga aatcctccac accaaataaa
     3001 aattaacatt agtttttatt tttgagaaca ttctctgatg tgtaacttgt tttcataagt
     3061 catacttttt ctggcttttt ttttttacaa tatattcttt aaatataaaa atcgacaaga
     3121 taaatacaat tttatctagc ctatttgtgg tttttctaag atccatcatt ggttttataa
     3181 aaaagtacca ggccaggaag caatggtgag agtaattttc cctttgagtt ctttgagcat
     3241 cctcgctaag caggcgtgca tcatccccga cgtgcttctg ccgttgacag caagaagaat
     3301 gtcaccacat ctgaaaagat acggcattgt gatcagaact gcttcaagcc tgaagcgcct
     3361 caaagtggac ttgggtggcc ctagggctgc catatttgtc ctttttagtt ctgatttgat
     3421 ttccctcttc ccataaattc tccaagctcc acgcagcgtg catcaaaggt ataggaaatt
     3481 gcaaggtggg accaaggccg gttctagttt tggatttctc tctacctagc tagtgctctc
     3541 gtgtcttaat ttctcactct ttaggaaagt ataagctgcg ctttcttcca agtggggcca
     3601 agttttacat gtagaaagca aaatacttga atattagttt tctgagtaat cattacctaa
     3661 ttcttccatc attatacgcg ggtgttccct cgacgatgga tttgataaaa aaaggttggt
     3721 taccactgta ttcttcataa cctcccacaa tgcagaagcc caggcttccc gctgtgttcc
     3781 ttcgtagtat cacatcctta cagttatata agtacctgaa acagaatgta attagtggat
     3841 gtacagttga gtttactagt tgtgactcct ttcattcatt tttttggggg acacttttaa
     3901 aatgaaaaat actgcatatg tctccatcag aagtgacagc aactttttat gctcttagtc
     3961 agcttttgca tttgatctct cttttccata gccaaatacc ctttcaacaa aaggagttag
     4021 tattatgttc tattcatgtc tctgctgaga aaaatggcca catattttgg ttaaggcgca
     4081 gtaatgaatg catgagccaa aagttggatg tgtctcagta cttcttattc cccacagtag
     4141 aacatactga gggaatatca tttttatatt cttgggggct tacataattt gtaaagaaga
     4201 caaacattct ctgaattagc gattaatcgc aaggacaata attttaactt atgctaatga
     4261 acttatactc acacagactt agagaagact agagaaagtg aatggaaatt gggccataaa
     4321 atagtggagc agttgtcgga cagtaagtgg catagctgaa gcagtcaggg gaagggaagg
     4381 agcacagctg gcctgagagc cagtacagcc ttcagctggg atagccgcgg ctaagtgtga
     4441 gcagctgcac tacagtagac tgtcggaaga tggggtcgct ctgggacccc ttgtctgccg
     4501 catgtgtcta ggaactgctt ttgactggaa gatagtattt tttgttgtta gaattgaaga
     4561 tgtcttgttt atagactgta ccttaaaata atcagttgct ttttgataat caataaaaat
     4621 gatcttgtga aatattaa
//
LOCUS       NM_001437210            3295 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus kelch-like family member 8 (Klhl8), transcript
            variant 4, mRNA.
ACCESSION   NM_001437210 XM_008770006
VERSION     NM_001437210.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Nam,S., Min,K., Hwang,H., Lee,H.O., Lee,J.H., Yoon,J., Lee,H.,
            Park,S. and Lee,J.
  TITLE     Control of rapsyn stability by the CUL-3-containing E3 ligase
            complex
  JOURNAL   J Biol Chem 284 (12), 8195-8206 (2009)
   PUBMED   19158078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_008770006.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.43804.1,
                                           SRR26360172.1194614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000014.1  6112497-6112621
            126-237             JAXUCZ010000014.1  6114582-6114693
            238-298             JAXUCZ010000014.1  6129491-6129551
            299-666             JAXUCZ010000014.1  6133127-6133494
            667-1215            JAXUCZ010000014.1  6143478-6144026
            1216-1402           JAXUCZ010000014.1  6145448-6145634
            1403-1546           JAXUCZ010000014.1  6147858-6148001
            1547-1658           JAXUCZ010000014.1  6149478-6149589
            1659-1827           JAXUCZ010000014.1  6152615-6152783
            1828-1987           JAXUCZ010000014.1  6152981-6153140
            1988-2189           JAXUCZ010000014.1  6155779-6155980
            2190-3295           JAXUCZ010000014.1  6156877-6157982
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3295
                     /gene="Klhl8"
                     /note="kelch-like family member 8"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
     exon            1..125
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            126..237
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            238..298
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            299..666
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    337..339
                     /gene="Klhl8"
                     /note="upstream in-frame stop codon"
     CDS             448..2313
                     /gene="Klhl8"
                     /note="kelch-like 8"
                     /codon_start=1
                     /product="kelch-like protein 8"
                     /protein_id="NP_001424139.1"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
                     /translation="MASESTNGKLARSHVTKGRRQQQQQQQVRSRSSVSECDGDDSFI
                     FEANEAWKDFHGSLLGFYENGELCDVTLKVGSKLISCHKLALACVIPYFRAMFLSEMS
                     EAKQALIEIRDFDGDAVEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY
                     MKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL
                     SSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPVDFLMGVVAKEQI
                     VKQNLKCRDLLDEARNYHLHLSSKPVPDFEYSVRTTPRKHTAGVLFCVGGRGGSGDPF
                     RSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTN
                     KWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMNTP
                     RGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHG
                     CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN
                     AYLNTVEAFDPVLNKWELVGPVSHCRAGAGVAVCDCLTSQIRDVGHGSTNVVDCM"
     misc_feature    604..963
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    604..963
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    628..2055
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    628..2055
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    1516..1647
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1516..1647
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1657..1791
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1657..1791
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1798..1935
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1798..1935
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1939..2076
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1939..2076
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2080..2208
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2080..2208
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2113..2250
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    2113..2250
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     exon            667..1215
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1402
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1546
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1658
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1827
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1987
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2189
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..3295
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccggg cacgagcaag cgggcgggca agtgagcgcg tccgccgagt gtcggagctg
       61 ggctggcgcg gcgccggcac ggagcgggtg tggcggctcg gcctgcgcgg cggccgcgga
      121 cagagtgctg gagatcaaat tcagttgact atttaaaata caccaattac tgtttactgc
      181 ttctgcggcc aacatctcgt gtgtggtcgg tcagcctgtt tgctctgctc tgaggagaag
      241 ctgcttaact tcagacaacc tctgtggtcg gttcctggga tccttttctg actttccaca
      301 aactgtctaa tgaaattgaa ggtttcgaaa gatgtctaaa gcttagtggc cacatctatc
      361 gtctgtcttc tgacccttaa aaaaaaaaaa acaaagaata aatgggatgt ttcagaagag
      421 agctatttaa aaggaagagt gttgcaaatg gcttcagaat ctaccaatgg gaagctagct
      481 aggagtcacg tgacaaaggg gcggcgtcag cagcagcagc agcagcaggt gaggagccgg
      541 tcctctgtca gcgagtgcga tggcgacgac tccttcatct tcgaagccaa cgaggcctgg
      601 aaggactttc acggctctct cctgggcttc tatgagaacg gggagctctg tgacgtcact
      661 ctaaaggtcg gctcgaagct catctcctgc cacaagctgg cgctggcttg tgtcatcccc
      721 tacttcagag ccatgtttct ttctgaaatg tctgaggcta agcaggcgct gatcgagatt
      781 cgggactttg acggcgatgc cgtggaggac ttggtgaagt tcgtctactc ttcgcggctc
      841 actctgacag tggacaacgt ccagcctctg ctgtatgcag cgtgcatcct gcaggttgaa
      901 ctggtggcca gagcttgctg cgaatacatg aagctacact ttcatccctc caactgcctg
      961 gctgtgcgag cctttgcgga gagtcacaac cgaacagacc taatggacat ggcggaccag
     1021 tatgcgtgcg agcactttac tgaagtggta gagtgtgagg acttcgtgag cgtgtcccca
     1081 cagcacctgc acaagctcct ctcctccagc gacctcaaca tcgacagcga gaagcaggtc
     1141 tacagtgccg ccatcaagtg gcttcttgcc aacccacagc atcaccctaa atggctggac
     1201 gagacccttg cccaggtccg tctgccactc ttgccagtgg atttcctcat gggcgttgtg
     1261 gcaaaagagc agattgtcaa gcaaaatctg aaatgtagag acctactgga tgaagccaga
     1321 aattaccacc ttcatttgag cagtaaacca gttcctgact ttgagtattc agtccgaact
     1381 accccgagga agcatactgc tggtgtgctg ttctgtgtgg gtggtcgagg tggatctggt
     1441 gacccctttc gtagtatcga atgctattct atcaacacaa acagctggtt ctttggacca
     1501 gaaatgaaca gccgcaggag gcatgtgggc gtgatctctg tggaagggaa agtgtatgcc
     1561 gtgggcggcc atgatgggaa cgagcaccta ggcagcatgg agatgtttga ccctctcact
     1621 aacaaatgga tggtgaaggc atcgatgaac accaagaggc gaggaattgc cttggcctcc
     1681 ttagggggcc caatatatgc gattggagga ttagatgaca acacttgctt cagtgacgtg
     1741 gagagatacg acattgaatc tgaccagtgg agtacggtgg cgccaatgaa cactccccgt
     1801 ggaggtgtcg gctctgtggc tttaatcaac catgtttacg cagtgggtgg caacgatggc
     1861 gtagcctcct tgtccagtgt ggaaaggtat cacccgcatc tggataagtg ggtggaggtg
     1921 aaggagatgg gccagcggag agccggcaat ggtgttagtg agcttcacgg ctgcttatac
     1981 gttgttggtg gttttgatga taattcccct ctgagttcgg ttgagcggta cgatcctcgg
     2041 agcaacaagt gggactatgt ggcagcgctc accactccca ggggtggcgt agggattgcg
     2101 acggtgatgg gcaagatctt tgcagtcgga ggccacaacg gcaatgccta cctcaacaca
     2161 gtggaggcgt tcgaccctgt gctgaataaa tgggaactgg tcggacctgt gtctcactgc
     2221 cgagctggtg ccggtgtggc cgtgtgtgac tgcttaacta gccagatccg agacgtaggt
     2281 catgggtcca ctaacgtggt tgactgtatg tgattaagtc ccagcaacaa ggatacagtg
     2341 ccatctgatg gacgggaaga cgagcctttc aacatggcgc atttgattgt gaccacagct
     2401 actgtctttg agtgtcagct gttgtaagta ggtctgtggg ctgacggtga gagctgctag
     2461 tcacagagtg aagtgagctg tttcctgcct cagcagacag tgagtaggct ggaagcagcc
     2521 tgtcagccca ttcttgcgct gagagacgtt tcatgtagtg ccaaacctta aaatagctgt
     2581 ttattttgat gaataaaatg taatttattg agttttatct gttctttttc ctgaagaaac
     2641 taacttcagg cagtagattt ttttcccaga ggagagagaa gtccactcat caacatgaga
     2701 acttgaggcc tgctcccttg aggatcactc tacatggtgc tggtgaatgt atgtcttgct
     2761 ttttgtctcc agatggtgac tttcagttct tgggtgttta tgaagtaggg aaaatgtttg
     2821 tgtgtttctg agacattctt gaaaccacat tagtgtctgt aagaaggcct tggcctccat
     2881 gtggagtttt agaaccacag gacatagctg tgcctgcttc ctcaccaagt gtactggccg
     2941 ccattctttt cccattcgtg agagtttctt ggtgatgacc gtggcttggc atgagtgcag
     3001 cgtccagtga aaagactgag aaggatgtat gaagcccatg cccacctagg gaggttgtgg
     3061 aggctccttt aaccttgttc ttctgcttag tcgttgaatt tggaaccagg acccattttc
     3121 tcttactctg tcatttgtcg ccgtcttggg tttcctaatt gtacaaagct gaatttattt
     3181 attatcagga catgaatgcg tttttacaac attcctttct gcagtatagt ctgatgatta
     3241 gttccagttt gtcattaatc aataaaatat gttgctggta aaaacagaaa aaaaa
//
LOCUS       NM_001437179            2110 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 16, mRNA.
ACCESSION   NM_001437179
VERSION     NM_001437179.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74654.1,
                                           SRR26360176.2433630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-487             JAXUCZ010000018.1  69732881-69732980
            488-670             JAXUCZ010000018.1  69736744-69736926
            671-826             JAXUCZ010000018.1  69740845-69741000
            827-934             JAXUCZ010000018.1  69741592-69741699
            935-2110            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2110
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            388..487
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..988
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 8 is encoded by transcript variant 16;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 8"
                     /protein_id="NP_001424108.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVRKYKKVMLDLL
                     VHGLYDPVSSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSA
                     FVLFGQLAAFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKP
                     RKEQSFQSEEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    509..610
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    509..610
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    638..727
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    638..727
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            488..670
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            671..826
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            827..934
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2110
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagttt catggaacaa atgcagagaa tcccgaacca
      421 gcccctcccc acccctgctt ctcagtccaa gaagaggagg acaccactgt catctttctt
      481 ttccaaggtg agaaagtata agaaagttat gcttgacctg ctggtacacg ggctgtatga
      541 tcctgtgagt tccgaagtca ttcatgagag tgtgaagacg ctgactatca tgttgggcaa
      601 gatccagggc caacggctgg gctccttctt catagacatc acccttcaga cccggaccct
      661 attggatgat gaggatgaca gcgtgcgcta ctcagccttt gtcctctttg ggcagttggc
      721 tgcatttgct gggcggaaat ggaagaagtt cttcacccac caggtcaacc agacccaaga
      781 ttccctccta agccatttgc aggacgaaag ccctcaggtt gccaaggctt gcacaatggc
      841 tgttcaagcc tgtgttccat acctgaaacc cagaaaggag cagagtttcc aaagtgaaga
      901 agaccagaag aaccgcaggc tttcccagca actgagccac taccatccag agatcctgct
      961 gttcttctat gccaataaaa tcctgtaggt ccagagcagc agagaaagcc cacgggagtg
     1021 ccctgccccg gcatggaatt tcccatctgt ctcataggat acctctttga ctctcgagtg
     1081 attgtaagag aaaagaggat gtcagagagc aactgaaaaa aaaatcaccc tggagtgcac
     1141 gcaaagtaaa attctatgca agtgtgtgca catacatgca catgactgtg gaggtcagag
     1201 gacgacctca ctgctgttcc taaggcgtca tccatctttc cactgaaaca ggatctttga
     1261 ctggcctggg gcttgcagga gcttagacta ggcttgatag ctagtgagcc agctctgggg
     1321 ttataaccac agtccatcga accaaccgtt tttgactgtg ccaaattcag gcccttatac
     1381 ctacttgtgc tgactaagcc gtctccccag cccagtagat gcacacttcc ttaaaacatt
     1441 taacatgcat gatgtcccaa tccctccttt ctcactccct ctctgccagg tgacacacat
     1501 ttataatatg taacttctga ggcttggggg aacaattgtt accttaaaca tttttaaact
     1561 gtatttgttt ttgatagttt gctatttgct acggaccagg agaccaagga gctggcttac
     1621 aatgtgtctt taatttcgga tgatcttaaa atgtcatggt cttaaaatcg tctttaaaaa
     1681 gaacaacaag gaaaagaaat attgttgaaa atccactgaa tgatgataag ttacagaata
     1741 aaaacagtaa catttactga gaatgcttac aacttatttc ggtactgtgg tggtttggat
     1801 gagcgaccct gcaggcttac gtatttgaat gcttggtccc ttcttagtgg aagtgtttag
     1861 gaggggttag agggtgtgta tatcactgga gatggaattt gagacttcag aagcccaagc
     1921 aaggccctgt ctgtctgtct gtctgtctgt ctgtccgtct cttattttgc ctgcctactg
     1981 tctacagatc aagacgtaaa gctctcagtt actactctag caccatgcct gtctactcct
     2041 accatgatga taatgaactg gccttctaaa actctaagcc agccccaatt aaacgcttcc
     2101 ttttataaga
//
LOCUS       NM_001437214            4611 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 5, mRNA.
ACCESSION   NM_001437214 XM_039091687
VERSION     NM_001437214.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4611)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4611)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4611)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4611)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4611)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4611)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4611)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4611)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_039091687.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.51564.1,
                                           SRR26643284.17027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-904             JAXUCZ010000014.1  34017713-34017781   c
            905-1014            JAXUCZ010000014.1  34009985-34010094   c
            1015-1108           JAXUCZ010000014.1  33995782-33995875   c
            1109-1265           JAXUCZ010000014.1  33994406-33994562   c
            1266-1320           JAXUCZ010000014.1  33981524-33981578   c
            1321-1376           JAXUCZ010000014.1  33980419-33980474   c
            1377-1596           JAXUCZ010000014.1  33976291-33976510   c
            1597-1734           JAXUCZ010000014.1  33972832-33972969   c
            1735-4611           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4611
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..1882
                     /gene="Fip1l1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     5"
                     /protein_id="NP_001424143.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTME
                     VTPGAEIQDGRFNLFKVQQGRTGNSEKEAALPSTKAEFTSPPSLFKTGLPPSRRLPGA
                     IDVIGQTITISRVEGRRRANENSNIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPP
                     PPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNV
                     AFPHLTSSAPSWPSLVDTTKQWDYYARREKDRDRDRERDRDRERERDRDRERERTRER
                     ERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKS
                     SRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPVPEQESTEAAPAE"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..904
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1014
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1108
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1265
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1320
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1376
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1734
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..4611
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggccga
      841 agactgtact atggaagtca caccaggtgc agagatccaa gatggcagat tcaatctttt
      901 taaggtacag caagggagaa ctggaaattc agagaaagaa gcagcacttc catctacaaa
      961 agctgagttt acttctccgc catcattgtt caagactggt ctgccaccaa gcaggagatt
     1021 acctggagca atcgatgtca ttggtcaaac aataaccatc agccgagtag aaggaagacg
     1081 gcgtgcaaat gagaacagca atatacaggt tctttctgac agatctgcca ctgaagtaga
     1141 caacaatttc agcaaaccac ctccattttt ccctccaggg gctcctccta ctcaccttcc
     1201 tcctcctcca tttcttccac ctcctccaac tgtcagcact gctccacctt tgattccacc
     1261 accaggtttc ccccctccac caggcgctcc acctccatct cttataccga caatagaaag
     1321 tggccattcc tctggttacg acagccgttc tgcacgggcg tttccatatg gcaatgttgc
     1381 ctttccccac cttaccagtt ccgctccctc atggcctagc cttgtggata ccactaagca
     1441 gtgggactat tatgcacgga gagaaaaaga tcgagatcga gaccgagaga gagaccgaga
     1501 cagagaaagg gagagagacc gggacagaga aagggagcgc acccgggagc gagagcggga
     1561 gcgggaccac agccccaccc caagtgtttt caacagtgat gaagagcgat acagatacag
     1621 ggagtatgca gagagaggct atgagcgcca cagagctagt cgggagaaag aagagcggca
     1681 cagagaacga cggcacagag agaaggagga aacaagacac aagtcctctc gcagtaatag
     1741 tagacgtcgt catgaaagtg aagaagggga cagtcacaga agacacaagc acaaaaagtc
     1801 taaaaggagc aaagaaggaa aagaggctgg cagcgagccg gtccctgagc aggagagcac
     1861 ggaagctgcc cctgccgagt aggcgccacc tcttatgtac gtcagcccca gaaatagatg
     1921 ctataaatct ccttattttt ctggataatg tttaagaaat gtacctttaa tcttgttctg
     1981 ttagaatgaa acgttaactt tttcttttcc aaaataaaag tgtgcatttt tttgtgttaa
     2041 gttaaaaatc tttgtcttgt aatatttaaa gaataaaaga caaaaattac tttatatcta
     2101 agaaagtaat gtgaataagt cagcagggga cttagtgcta agttggccgt gtgtgcagtg
     2161 tggtgaggat caaggactca ctagctttct agtgagcggg acgctgtcgg caggagaggt
     2221 gctgtggtgc agaagcccct ctcatgtgac gtcaggcttc ctcttactgc tgtcacactc
     2281 ctgcatcttt aagaacttgg acacattctt gttatcacag ttttgatagc aggttttcag
     2341 tggtccatag taactaaatg gactgtttga atctctgact ttagagatgg tctgaggcac
     2401 ttgggtggcc ctatgatgga acttgtgtgc ttcccagcag gcacatggac tggcacagcg
     2461 tcaaaccact tcatggccat ctgtttgaac aagggtcaag ggcttcagct gctgctaacg
     2521 tgttttccaa ggctcattgg tagcatagaa cgtggggtat tttttgtaat accaggtcca
     2581 tattaataaa aaataaactc agtgagagta gtgtcagatc agtcattctt actaaaacca
     2641 gaactccagg ttaaaatctg gactaacccc aagaaggttc cagagcagcg gtggggctgg
     2701 gaatgtgtgt gaaaggacga ggcagttaga gccaccagta agaggactgc ggtcacttag
     2761 aagaagatat tcatctcttg ttcaaatcct ccgccattaa actgaaatgg ccataatgtg
     2821 ctgtgtcttc aactccactt ctaccacatt tgacgttgcc ttgaattaag tgtggcatac
     2881 aaaccatgta agtttttatg ggctttttat tgaattaaaa aaatagaaac ttaaaagatt
     2941 tggagtgatg agaaatcctc cacaccaaat aaaaattaac attagttttt atttttgaga
     3001 acattctctg atgtgtaact tgttttcata agtcatactt tttctggctt ttttttttta
     3061 caatatattc tttaaatata aaaatcgaca agataaatac aattttatct agcctatttg
     3121 tggtttttct aagatccatc attggtttta taaaaaagta ccaggccagg aagcaatggt
     3181 gagagtaatt ttccctttga gttctttgag catcctcgct aagcaggcgt gcatcatccc
     3241 cgacgtgctt ctgccgttga cagcaagaag aatgtcacca catctgaaaa gatacggcat
     3301 tgtgatcaga actgcttcaa gcctgaagcg cctcaaagtg gacttgggtg gccctagggc
     3361 tgccatattt gtccttttta gttctgattt gatttccctc ttcccataaa ttctccaagc
     3421 tccacgcagc gtgcatcaaa ggtataggaa attgcaaggt gggaccaagg ccggttctag
     3481 ttttggattt ctctctacct agctagtgct ctcgtgtctt aatttctcac tctttaggaa
     3541 agtataagct gcgctttctt ccaagtgggg ccaagtttta catgtagaaa gcaaaatact
     3601 tgaatattag ttttctgagt aatcattacc taattcttcc atcattatac gcgggtgttc
     3661 cctcgacgat ggatttgata aaaaaaggtt ggttaccact gtattcttca taacctccca
     3721 caatgcagaa gcccaggctt cccgctgtgt tccttcgtag tatcacatcc ttacagttat
     3781 ataagtacct gaaacagaat gtaattagtg gatgtacagt tgagtttact agttgtgact
     3841 cctttcattc atttttttgg gggacacttt taaaatgaaa aatactgcat atgtctccat
     3901 cagaagtgac agcaactttt tatgctctta gtcagctttt gcatttgatc tctcttttcc
     3961 atagccaaat accctttcaa caaaaggagt tagtattatg ttctattcat gtctctgctg
     4021 agaaaaatgg ccacatattt tggttaaggc gcagtaatga atgcatgagc caaaagttgg
     4081 atgtgtctca gtacttctta ttccccacag tagaacatac tgagggaata tcatttttat
     4141 attcttgggg gcttacataa tttgtaaaga agacaaacat tctctgaatt agcgattaat
     4201 cgcaaggaca ataattttaa cttatgctaa tgaacttata ctcacacaga cttagagaag
     4261 actagagaaa gtgaatggaa attgggccat aaaatagtgg agcagttgtc ggacagtaag
     4321 tggcatagct gaagcagtca ggggaaggga aggagcacag ctggcctgag agccagtaca
     4381 gccttcagct gggatagccg cggctaagtg tgagcagctg cactacagta gactgtcgga
     4441 agatggggtc gctctgggac cccttgtctg ccgcatgtgt ctaggaactg cttttgactg
     4501 gaagatagta ttttttgttg ttagaattga agatgtcttg tttatagact gtaccttaaa
     4561 ataatcagtt gctttttgat aatcaataaa aatgatcttg tgaaatatta a
//
LOCUS       NM_001437188            4003 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus adducin 1 (Add1), transcript variant 7, mRNA.
ACCESSION   NM_001437188 XM_063272847
VERSION     NM_001437188.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4003)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4003)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4003)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4003)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 4003)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 4003)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 4003)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 4003)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 4003)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 4003)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_063272847.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1303223.1,
                                           SRR26360176.1479920.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000014.1  80391692-80391851   c
            161-375             JAXUCZ010000014.1  80364782-80364996   c
            376-538             JAXUCZ010000014.1  80361344-80361506   c
            539-690             JAXUCZ010000014.1  80360265-80360416   c
            691-771             JAXUCZ010000014.1  80355305-80355385   c
            772-921             JAXUCZ010000014.1  80354818-80354967   c
            922-1065            JAXUCZ010000014.1  80352381-80352524   c
            1066-1164           JAXUCZ010000014.1  80352191-80352289   c
            1165-1341           JAXUCZ010000014.1  80351463-80351639   c
            1342-1593           JAXUCZ010000014.1  80348939-80349190   c
            1594-1638           JAXUCZ010000014.1  80348287-80348331   c
            1639-1740           JAXUCZ010000014.1  80346327-80346428   c
            1741-1830           JAXUCZ010000014.1  80345653-80345742   c
            1831-1987           JAXUCZ010000014.1  80340292-80340448   c
            1988-2086           JAXUCZ010000014.1  80337025-80337123   c
            2087-2123           JAXUCZ010000014.1  80336380-80336416   c
            2124-4003           JAXUCZ010000014.1  80333242-80335121   c
FEATURES             Location/Qualifiers
     source          1..4003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4003
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..160
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..375
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Add1"
                     /note="upstream in-frame stop codon"
     CDS             181..2124
                     /gene="Add1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     alpha-adducin; erythrocyte adducin subunit alpha;
                     alpha-ADD; adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 7"
                     /protein_id="NP_001424117.1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFFYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKPPNAYASCPPHGLLHWTKEDGHRTSTSAVPNLFVPLN
                     TNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQ
                     PHVIVSTTGPNPFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPN
                     TPPSTPVKLEGAGDGCAKEYLLP"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    613..1353
                     /gene="Add1"
                     /note="Class II Aldolase and Adducin head (N-terminal)
                     domain. Aldolases are ubiquitous enzymes catalyzing
                     central steps of carbohydrate metabolism. Based on
                     enzymatic mechanisms, this superfamily has been divided
                     into two distinct classes (Class I and II); Region:
                     Aldolase_II; cl00214"
                     /db_xref="CDD:469663"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(631..633,643..645,667..669,742..744,748..753,
                     901..903,907..912,925..933,955..957,961..966,997..999,
                     1081..1083,1114..1116,1135..1137,1147..1149,1168..1170,
                     1222..1224)
                     /gene="Add1"
                     /note="intersubunit interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(682..684,733..738,811..819,895..897,901..903,
                     1084..1086)
                     /gene="Add1"
                     /note="active site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     misc_feature    order(895..897,901..903,1084..1086)
                     /gene="Add1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238232"
     exon            376..538
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1065
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1164
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1341
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1593
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1638
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1740
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1830
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1987
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2086
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2123
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..4003
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaggg gtgagggttg agggcgggag aggacgaggg ctgctgcagg cggcgggggt
       61 gcgcggcagc cagggggcgg agcccagcgc gagccgcagg cgaggcggcg gccgcactcg
      121 gacccgggaa gctgtgcgct tttcccgatt ctccgcggag gatcctagaa acattgtgca
      181 atgaatggtg acacgcgggc cgcagtggtg acctcaccac ctccaaccac agcccctcac
      241 aaggagaggt actttgacag agtcgatgag aacaatccag aatatttgcg ggagaggaac
      301 atggcaccag accttcgtca ggacttcaat atgatggagc agaagaagag ggtgtctatg
      361 attctgcaga gtcccgcctt ctgtgaagag ctggagtcta tgatacagga gcagtttaag
      421 aaggggaaga accctacagg cctgttggca ttacagcaga ttgcggattt catgacggcg
      481 agtgtgccca atgtctaccc ggcagctcca caaggaggaa tggccgccct gaacatgagt
      541 cttggtatgg ttactcctgt gaatgacctt agaggatctg attctattgc atatgacaag
      601 ggggagaagt tactgcgatg taagctggca gcattttaca gactagcaga cctctttggc
      661 tggtctcagc ttatctacaa tcacatcaca accagagtga actctgagca ggagcacttc
      721 ctcatcgtgc ctttcggact tctctacagt gaagtgactg cgtccagcct ggttaaggtc
      781 aatctacaag gagacatagt agaccgcgga agtactaacc tgggagtcaa ccaggccggc
      841 ttcaccttgc actcggccat ttatgctgca cgaccagatg ccaagtgcat tgtgcacatt
      901 cacacaccag caggggctgc ggtctctgca atgaagtgtg ggctcttgcc tatttccccg
      961 gaggcgcttt cccttggaga ggttgcttat catgactatc atggcattct ggttgatgaa
     1021 gaggaaaaaa ttttgattca gaagaatctg ggccctaaaa gcaaggttct cattctccgg
     1081 aatcacgggc tcgtgtcagt tggagagagt gtggaggagg ccttctttta tatccacaac
     1141 cttgtggttg catgtgagat ccaggttcga actctggcaa gtgctggagg accagacaac
     1201 ttagttctgc tggatcctgg gaagtacaaa gccaaatccc gttctccagg gactccagca
     1261 ggggaaggct ctggatcacc tcccaagtgg cagattgggg agcaggaatt tgaagctctt
     1321 atgcggatgc tcgataatct gggctacaga actggctacc cctatcgata ccctgctctg
     1381 agagagagat ctaaaaagta cagcgatgtg gaagtccctg ccagtgtcac cggccactcc
     1441 tttgctagtg acggcgattc gggcacttgc tcgccgctca gacacagttt tcagaagcag
     1501 cagcgagaga agacaagatg gctgaactct ggccggggtg atgacgcttc tgaggagggg
     1561 cagaacggaa gcagtcccaa gtcgaagact aagcctccga atgcttatgc cagctgccct
     1621 ccgcatggac tgttgcattg gactaaagag gatggacata gaacttccac ctctgctgtc
     1681 cctaacctgt ttgttccatt gaacactaac ccaaaagagg tccaggagat gaggaacaag
     1741 attcgagagc agaacttaca ggacattaag acggcaggac ctcagtcgca ggttttgtgt
     1801 ggtgtgatga tggacagaag ccttgtccag ggggagctcg tgacggcctc caaagccatc
     1861 attgagaagg aataccagcc tcatgtaatt gtgagcacca caggtcccaa ccccttcaac
     1921 acgctcacag accgtgaact agaggaatac cgccgagagg tggagcggaa gcagaagggc
     1981 tctgaagaga acctggacga gacaagagag cagaaagaga agagtcctcc agaccagtca
     2041 gctgttccca acactccgcc cagcactccc gtcaagcttg aaggagcagg agacggatgt
     2101 gctaaagagt acctgttacc ctagccttcc ccaggagccg acatccaggg atggcagcga
     2161 tgccaccacc tccaagccga ctccccctga cctctcccct gatgagcctt cagaagcact
     2221 tgccttccca acagtggcag aggaagccca tgcttcccca gacaccactc agccccttgc
     2281 tgaggctgac cctgagccag cctcagcctc agctccagga gctgaagagg tagcctcccc
     2341 tgccactgag gaggggtctc ccatggaccc tggcagcgat gggtctccag gcaagtcccc
     2401 atccaagaag aagaagaagt tccgcacccc gtccttcctg aagaagagca agaagaagag
     2461 tgactcctga aggcccaccc tgcatactgt cgtgtctgaa ggcctggctc tgccaggact
     2521 ccctcctctg tcttgtgttc tgtcctctcg tgtaatggaa tgcaaaaagc caagacctcc
     2581 atgtaactag agccccctcc catgtatggt cagcccctgc accagtgcta acccagtgtg
     2641 tgctcagccc ctctaccctg ggccttgggt tctgtgggga gttgggctta gcctgcacct
     2701 gtgagttgtg cccccctgca ggagggggac actgaatcct ggtcctggct ggaaggcata
     2761 ggaggcttct gccagctctg gttacagcgt caccctcctg agccttgcct ctcactctcc
     2821 tttctgtcgt gagtattgaa ttgtctgctc agtttccctc caccctgtgg agtctcaggt
     2881 ggctgatttg gactcggctt tgctggcatc ctctgctccg tgatgtcagt tatccccata
     2941 cacaggtatc cacatacccc agccatggtc tgagaaaaca ctctcatgtc catccgcggc
     3001 ccacactgtg gctgccttaa agacatgggt taagtctgct gccctagcag tgagcaaccc
     3061 tttgtatacc cagcacaacg ctatgcatgg tctaactgat gaccccatga ccaaaaccac
     3121 attcaggcgc tcatagttga ccttaccggg gtcttgcatt cccatcttag ggaacagata
     3181 ccaggagggg gaagagtcct ttctaaaact ttgtttcagc aggtttgcga tttagcctcc
     3241 atttttactg tgaacttgaa caggccactt tttgcgttag tttttgttgt agagcctatg
     3301 acagactgca gcagaacact cttgacttgt gtggggaggt tttgtaggaa cagggaccat
     3361 aactcagtct gaacgatgcc ctggttttga tagggatggt aactcatggt tgaagctggc
     3421 tttggaggtg ccatctaatg tcttgcatca ttcatggagc ccatgacctt cttggtcatc
     3481 ccttatgaat ttttacctaa cttttatccc tggaaaaggg cttgaaactg ctttagtgag
     3541 tggggaagcc gagtgtcagg tggaatccta aggggccttg ttccaggagc tgccactgcc
     3601 agcctgacta ggagagggag cctgctgggg ccctccacgc ccctgctggg ttgggcctca
     3661 tagagcgggt gctcggatgt ggacagaacc ctgtgatctc ccaatggggc accaagcagg
     3721 accccacagc ctgctgtact gctagtccca ctagtcacca cggtggcctg agctctcacc
     3781 tggtcctgag tcccctcatc tggactcctc ctcgtcttcc ttctggccct tcctttatcc
     3841 cacatatgca atgacttctc acttttgtag tctaatcttt gtattacaca cggaatatcg
     3901 ctgcatatat ggacagactt ggaggacagg tcctgtgtgt cctttcctcg tcgtaacagg
     3961 tcttactcac aaataaaagt ctttaagcag tttctttgtc taa
//
LOCUS       NM_001437205            3215 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 5, mRNA.
ACCESSION   NM_001437205 XM_039091592
VERSION     NM_001437205.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3215)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3215)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3215)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3215)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3215)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3215)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_039091592.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.56333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-351             JAXUCZ010000014.1  21565940-21565975   c
            352-453             JAXUCZ010000014.1  21560488-21560589   c
            454-782             JAXUCZ010000014.1  21559484-21559812   c
            783-1215            JAXUCZ010000014.1  21558937-21559369   c
            1216-1305           JAXUCZ010000014.1  21556341-21556430   c
            1306-1400           JAXUCZ010000014.1  21555171-21555265   c
            1401-1509           JAXUCZ010000014.1  21553803-21553911   c
            1510-1627           JAXUCZ010000014.1  21553603-21553720   c
            1628-1712           JAXUCZ010000014.1  21550070-21550154   c
            1713-1879           JAXUCZ010000014.1  21548930-21549096   c
            1880-1962           JAXUCZ010000014.1  21546400-21546482   c
            1963-1999           JAXUCZ010000014.1  21545168-21545204   c
            2000-2039           JAXUCZ010000014.1  21545032-21545071   c
            2040-2102           JAXUCZ010000014.1  21544877-21544939   c
            2103-2237           JAXUCZ010000014.1  21543336-21543470   c
            2238-3215           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3215
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2462
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 5 is encoded by transcript variant 5; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 5"
                     /protein_id="NP_001424134.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKEDCQDCSSWLFSDGELNVLDDILTEVPEQDDELYN
                     PESEQDKNEKKGSKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGK
                     SVTEYKNEEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPT
                     PDGSERIGLEVDRRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEE
                     DVEEDEEVDEDGDDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEG
                     NDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSA
                     SESYADQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSAR
                     SVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRREL
                     PFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKR
                     RMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRY
                     QEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHPYYQHHA
                     PPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRER
                     ERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR"
     misc_feature    1344..1754
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1344..1754
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     exon            316..351
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            352..453
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            454..782
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1215
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1305
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1400
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1509
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1627
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1712
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1879
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1962
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..1999
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2039
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2102
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2237
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..3215
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagaagat tgccaagact gctccagctg gttgttttca gatggggaac
      361 ttaatgtttt agatgatatt ttgactgaag taccagaaca ggatgatgaa ctgtataatc
      421 cagagagtga acaagataaa aatgagaaaa aaggatcaaa aagaaaaagt gaaagaatgg
      481 aatctattga caccaagcga cagaagcctt ctatccattc aagacaactg atttctaagc
      541 cactaagctc atctgttagc aataataaaa gaatagttag tacaaaagga aagtcggtta
      601 cagaatataa aaatgaggaa tatcaaagat ctgaaaggaa caagcgtcta gatgctgatc
      661 gaaaaattcg tctgtcaagc agttcctcta gagaacctta caagagtcaa ccagaaaaac
      721 cttgtctacg gaaaagggat tctgaaagaa gggccaagtc tcctacacca gatggttctg
      781 agagaattgg gcttgaagtt gatagacgtg caagcagatc cagccagtct tcaaaggaag
      841 aggggaactc tgaggagtat ggctctgacc acgagacagg aagcagtgct tcttctgaac
      901 agggcaacaa cactgagaat gaggaggaag gaggggaaga agatgtagag gaagatgaag
      961 aggtagatga agatggagat gatgatgagg aagtggatga agatgcggag gaggaggagg
     1021 acgaggaaga agatgaggag gaggaggatg aggaagaaga agaggaagag gaagaagaat
     1081 atgaacagga tgagagagat cagaaggaag aagggaatga ttatgacacc cgtagtgagg
     1141 ccagtgattc tggttctgag tctgtttcct tcacagatgg atctgtcagg tctggttcag
     1201 gaacagatgg atcagatgag aaaaagaagg aaaggaagag agctcgaggc atatcaccca
     1261 ttgtctttga tagaagtggc agttctgcat cagagtcata tgcagatcaa accagtaaac
     1321 tcaaatatgt ccttcaggat gcaagatttt tcctcataaa gagtaacaac catgagaatg
     1381 tgtctcttgc caaagcaaag ggtgtatggt ccacattacc tgtaaatgag aagaaattaa
     1441 atcttgcgtt tagatctgca aggagtgtta tattaatatt ttctgtcagg gaaagtggaa
     1501 agtttcaagg ttttgccaga ttgtcatcag aatcgcatca tggtggctct cctatacatt
     1561 gggtgcttcc agcaggaatg agtgctaaaa tgcttggagg tgtttttaaa attgactgga
     1621 tttgcaggcg tgaattaccc tttactaagt cagctcatct caccaatccc tggaatgaac
     1681 ataagccagt aaagattgga cgtgatggac aggaaattga acttgaatgt ggaacccagc
     1741 tttgtcttct gtttccccct gatgaaagta ttgacttgta tcagctcatt cataaaatgc
     1801 gtcacaagag aagaatgcat tctcagcctc gatcaagagg acgtccatcc cgtcgagaac
     1861 cagtccggga tgtgggaagg cgtcgaccag aagattatga tattcataac agcagaaaga
     1921 aaccaaggat tgactatccc cctgagtttc accagagacc agggtattta aaggatcccc
     1981 gataccagga agttgacaga cgattttcag gagttcgccg agatgtgttt ttaaatgggt
     2041 cctacaatga ttatgtgagg gaatttcata acatgggacc accgcctcct tggcaaggaa
     2101 tgcctcctta cccgggaata gaacagcctc cacaccatcc ctactaccag caccatgccc
     2161 cgcctcctca agcccacccc ccttactcag gacaccatcc ggtaccacat gaagcaagat
     2221 acagagataa acgagtacat gactatgata tgagggttga tgatttcctt cgccgcacac
     2281 aagccgttgt cagtggtcgg agaagtagac cccgagaaag agatcgggag cgagagcgag
     2341 accgccctag agataacaga agagatagag agcgagacag aggtcgtgat cgagaaagag
     2401 agagagaaag aatatgtgat cgggacagag accgagggga aagaggtcgt tatcgaagat
     2461 aatgtgcttt ttggaagcac tgactgaaga taaaaaatat tgtatttttt ttgtgtgtgt
     2521 ttacaagtag taaatttatt ttcagctgtc tacttaaagc tcattgtgta gaaggattta
     2581 ttatcttctt tgttccaagc atgcagtaga ataagaactg gaaaactcag atccgccaaa
     2641 aaatgcacag ttgacagttg agttgacact tttattgggg cagaatggaa cagtccaaga
     2701 atgtagatat tgattcattc tccataaatg ttctttttac agtgtattca tcctagagtt
     2761 attttgtttg tttgttttcc ttcttttgga ccttggtcaa tactgccata gtattttgct
     2821 ttgtgtttct ataggtagct gcacacggtt cagtaaaaat aatgctgcta tcaagtatgc
     2881 agatattgag tatgatggtt tgactatatg gcagtgttgt agcagcctct cggtttctcc
     2941 tcttccctcc ttttttttaa acctataaat ccactttttt tttaagtctt caatgatgag
     3001 agcaatatta agaagacatt gctatctaat ttttaatctt tttaaataaa acgttcctat
     3061 gttcagtagc atggtcgatg ctattgttta gccttccttc caaactgtac attggcttgg
     3121 aatgttcagt tttgcgtgtg tggcagcaga agataacccc acattctaca ttgctactgt
     3181 tttgtatgaa ataaattggt aaagattgac actaa
//
LOCUS       NM_001437178            1969 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 15, mRNA.
ACCESSION   NM_001437178
VERSION     NM_001437178.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35237.1,
                                           SRR26643298.74648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000018.1  69725889-69725982
            95-246              JAXUCZ010000018.1  69726124-69726275
            247-346             JAXUCZ010000018.1  69732881-69732980
            347-529             JAXUCZ010000018.1  69736744-69736926
            530-685             JAXUCZ010000018.1  69740845-69741000
            686-793             JAXUCZ010000018.1  69741592-69741699
            794-1969            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..1969
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..94
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            95..246
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    125..127
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            247..346
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..847
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 8 is encoded by transcript variant 15;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 8"
                     /protein_id="NP_001424107.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVRKYKKVMLDLL
                     VHGLYDPVSSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSA
                     FVLFGQLAAFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKP
                     RKEQSFQSEEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    368..469
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    368..469
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    497..586
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    497..586
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            347..529
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            530..685
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            686..793
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1969
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtaagg aaaccagggc tgggaaaatc
      121 tcgctgactc accacatttg gaggccaatc ccgaatcggt ggaacaacgc gcctcccgag
      181 agacccagga ctagcctcca gccccgaaac agcggttctt cacgtgacag tcaccccagg
      241 agccagtttc atggaacaaa tgcagagaat cccgaaccag cccctcccca cccctgcttc
      301 tcagtccaag aagaggagga caccactgtc atctttcttt tccaaggtga gaaagtataa
      361 gaaagttatg cttgacctgc tggtacacgg gctgtatgat cctgtgagtt ccgaagtcat
      421 tcatgagagt gtgaagacgc tgactatcat gttgggcaag atccagggcc aacggctggg
      481 ctccttcttc atagacatca cccttcagac ccggacccta ttggatgatg aggatgacag
      541 cgtgcgctac tcagcctttg tcctctttgg gcagttggct gcatttgctg ggcggaaatg
      601 gaagaagttc ttcacccacc aggtcaacca gacccaagat tccctcctaa gccatttgca
      661 ggacgaaagc cctcaggttg ccaaggcttg cacaatggct gttcaagcct gtgttccata
      721 cctgaaaccc agaaaggagc agagtttcca aagtgaagaa gaccagaaga accgcaggct
      781 ttcccagcaa ctgagccact accatccaga gatcctgctg ttcttctatg ccaataaaat
      841 cctgtaggtc cagagcagca gagaaagccc acgggagtgc cctgccccgg catggaattt
      901 cccatctgtc tcataggata cctctttgac tctcgagtga ttgtaagaga aaagaggatg
      961 tcagagagca actgaaaaaa aaatcaccct ggagtgcacg caaagtaaaa ttctatgcaa
     1021 gtgtgtgcac atacatgcac atgactgtgg aggtcagagg acgacctcac tgctgttcct
     1081 aaggcgtcat ccatctttcc actgaaacag gatctttgac tggcctgggg cttgcaggag
     1141 cttagactag gcttgatagc tagtgagcca gctctggggt tataaccaca gtccatcgaa
     1201 ccaaccgttt ttgactgtgc caaattcagg cccttatacc tacttgtgct gactaagccg
     1261 tctccccagc ccagtagatg cacacttcct taaaacattt aacatgcatg atgtcccaat
     1321 ccctcctttc tcactccctc tctgccaggt gacacacatt tataatatgt aacttctgag
     1381 gcttggggga acaattgtta ccttaaacat ttttaaactg tatttgtttt tgatagtttg
     1441 ctatttgcta cggaccagga gaccaaggag ctggcttaca atgtgtcttt aatttcggat
     1501 gatcttaaaa tgtcatggtc ttaaaatcgt ctttaaaaag aacaacaagg aaaagaaata
     1561 ttgttgaaaa tccactgaat gatgataagt tacagaataa aaacagtaac atttactgag
     1621 aatgcttaca acttatttcg gtactgtggt ggtttggatg agcgaccctg caggcttacg
     1681 tatttgaatg cttggtccct tcttagtgga agtgtttagg aggggttaga gggtgtgtat
     1741 atcactggag atggaatttg agacttcaga agcccaagca aggccctgtc tgtctgtctg
     1801 tctgtctgtc tgtccgtctc ttattttgcc tgcctactgt ctacagatca agacgtaaag
     1861 ctctcagtta ctactctagc accatgcctg tctactccta ccatgatgat aatgaactgg
     1921 ccttctaaaa ctctaagcca gccccaatta aacgcttcct tttataaga
//
LOCUS       NM_001437171            2260 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 8, mRNA.
ACCESSION   NM_001437171
VERSION     NM_001437171.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.139832.1,
                                           SRR26643298.74655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-487             JAXUCZ010000018.1  69732881-69732980
            488-634             JAXUCZ010000018.1  69735312-69735458
            635-820             JAXUCZ010000018.1  69736741-69736926
            821-976             JAXUCZ010000018.1  69740845-69741000
            977-1084            JAXUCZ010000018.1  69741592-69741699
            1085-2260           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2260
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    266..268
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            388..487
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1138
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 4 is encoded by transcript variant 8;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 4"
                     /protein_id="NP_001424100.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPV
                     SSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLA
                     AFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQS
                     EEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    545..991
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    545..991
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     exon            488..634
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            635..820
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            821..976
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1084
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2260
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagttt catggaacaa atgcagagaa tcccgaacca
      421 gcccctcccc acccctgctt ctcagtccaa gaagaggagg acaccactgt catctttctt
      481 ttccaaggtc tcttggaaac tgaggttgca gaagcgggaa cctttgaaga atctgttttt
      541 cgtcttggca gaaagagccc ggggtcctaa tcctagaaag cgccatctag caatgagagg
      601 cctgggtatc ttggcccatg aagctcctga caagcaggtg agaaagtata agaaagttat
      661 gcttgacctg ctggtacacg ggctgtatga tcctgtgagt tccgaagtca ttcatgagag
      721 tgtgaagacg ctgactatca tgttgggcaa gatccagggc caacggctgg gctccttctt
      781 catagacatc acccttcaga cccggaccct attggatgat gaggatgaca gcgtgcgcta
      841 ctcagccttt gtcctctttg ggcagttggc tgcatttgct gggcggaaat ggaagaagtt
      901 cttcacccac caggtcaacc agacccaaga ttccctccta agccatttgc aggacgaaag
      961 ccctcaggtt gccaaggctt gcacaatggc tgttcaagcc tgtgttccat acctgaaacc
     1021 cagaaaggag cagagtttcc aaagtgaaga agaccagaag aaccgcaggc tttcccagca
     1081 actgagccac taccatccag agatcctgct gttcttctat gccaataaaa tcctgtaggt
     1141 ccagagcagc agagaaagcc cacgggagtg ccctgccccg gcatggaatt tcccatctgt
     1201 ctcataggat acctctttga ctctcgagtg attgtaagag aaaagaggat gtcagagagc
     1261 aactgaaaaa aaaatcaccc tggagtgcac gcaaagtaaa attctatgca agtgtgtgca
     1321 catacatgca catgactgtg gaggtcagag gacgacctca ctgctgttcc taaggcgtca
     1381 tccatctttc cactgaaaca ggatctttga ctggcctggg gcttgcagga gcttagacta
     1441 ggcttgatag ctagtgagcc agctctgggg ttataaccac agtccatcga accaaccgtt
     1501 tttgactgtg ccaaattcag gcccttatac ctacttgtgc tgactaagcc gtctccccag
     1561 cccagtagat gcacacttcc ttaaaacatt taacatgcat gatgtcccaa tccctccttt
     1621 ctcactccct ctctgccagg tgacacacat ttataatatg taacttctga ggcttggggg
     1681 aacaattgtt accttaaaca tttttaaact gtatttgttt ttgatagttt gctatttgct
     1741 acggaccagg agaccaagga gctggcttac aatgtgtctt taatttcgga tgatcttaaa
     1801 atgtcatggt cttaaaatcg tctttaaaaa gaacaacaag gaaaagaaat attgttgaaa
     1861 atccactgaa tgatgataag ttacagaata aaaacagtaa catttactga gaatgcttac
     1921 aacttatttc ggtactgtgg tggtttggat gagcgaccct gcaggcttac gtatttgaat
     1981 gcttggtccc ttcttagtgg aagtgtttag gaggggttag agggtgtgta tatcactgga
     2041 gatggaattt gagacttcag aagcccaagc aaggccctgt ctgtctgtct gtctgtctgt
     2101 ctgtccgtct cttattttgc ctgcctactg tctacagatc aagacgtaaa gctctcagtt
     2161 actactctag caccatgcct gtctactcct accatgatga taatgaactg gccttctaaa
     2221 actctaagcc agccccaatt aaacgcttcc ttttataaga
//
LOCUS       NM_001437209            3453 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus kelch-like family member 8 (Klhl8), transcript
            variant 3, mRNA.
ACCESSION   NM_001437209 XM_008770004
VERSION     NM_001437209.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3453)
  AUTHORS   Nam,S., Min,K., Hwang,H., Lee,H.O., Lee,J.H., Yoon,J., Lee,H.,
            Park,S. and Lee,J.
  TITLE     Control of rapsyn stability by the CUL-3-containing E3 ligase
            complex
  JOURNAL   J Biol Chem 284 (12), 8195-8206 (2009)
   PUBMED   19158078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_008770004.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1331123.1,
                                           SRR26643297.42726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000014.1  6112497-6112779
            284-395             JAXUCZ010000014.1  6114582-6114693
            396-456             JAXUCZ010000014.1  6129491-6129551
            457-824             JAXUCZ010000014.1  6133127-6133494
            825-1373            JAXUCZ010000014.1  6143478-6144026
            1374-1560           JAXUCZ010000014.1  6145448-6145634
            1561-1704           JAXUCZ010000014.1  6147858-6148001
            1705-1816           JAXUCZ010000014.1  6149478-6149589
            1817-1985           JAXUCZ010000014.1  6152615-6152783
            1986-2145           JAXUCZ010000014.1  6152981-6153140
            2146-2347           JAXUCZ010000014.1  6155779-6155980
            2348-3453           JAXUCZ010000014.1  6156877-6157982
FEATURES             Location/Qualifiers
     source          1..3453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3453
                     /gene="Klhl8"
                     /note="kelch-like family member 8"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
     exon            1..283
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            284..395
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            396..456
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            457..824
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    495..497
                     /gene="Klhl8"
                     /note="upstream in-frame stop codon"
     CDS             606..2471
                     /gene="Klhl8"
                     /note="kelch-like 8"
                     /codon_start=1
                     /product="kelch-like protein 8"
                     /protein_id="NP_001424138.1"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
                     /translation="MASESTNGKLARSHVTKGRRQQQQQQQVRSRSSVSECDGDDSFI
                     FEANEAWKDFHGSLLGFYENGELCDVTLKVGSKLISCHKLALACVIPYFRAMFLSEMS
                     EAKQALIEIRDFDGDAVEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY
                     MKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL
                     SSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPVDFLMGVVAKEQI
                     VKQNLKCRDLLDEARNYHLHLSSKPVPDFEYSVRTTPRKHTAGVLFCVGGRGGSGDPF
                     RSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTN
                     KWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMNTP
                     RGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHG
                     CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN
                     AYLNTVEAFDPVLNKWELVGPVSHCRAGAGVAVCDCLTSQIRDVGHGSTNVVDCM"
     misc_feature    762..1121
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    762..1121
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    786..2213
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    786..2213
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    1674..1805
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1674..1805
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1815..1949
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1815..1949
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1956..2093
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1956..2093
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2097..2234
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2097..2234
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2238..2366
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2238..2366
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2271..2408
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    2271..2408
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     exon            825..1373
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1560
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1704
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1816
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1985
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2145
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2347
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..3453
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccggg cacgagcaag cgggcgggca agtgagcgcg tccgccgagt gtcggagctg
       61 ggctggcgcg gcgccggcac ggagcgggtg tggcggctcg gcctgcgcgg cggccgcgga
      121 cagaggtaac cgctgcgtcg tccggcgcac gggactcagc ctggagcggc cacccgcgtt
      181 cgcgtcggtg aggagcggcc gggcggcgcc agcgccatcc ctcggggaac cgaagggatc
      241 cgggcgggcc tcgcgggccg cgctgccgcg agcggcgacg cagtgctgga gatcaaattc
      301 agttgactat ttaaaataca ccaattactg tttactgctt ctgcggccaa catctcgtgt
      361 gtggtcggtc agcctgtttg ctctgctctg aggagaagct gcttaacttc agacaacctc
      421 tgtggtcggt tcctgggatc cttttctgac tttccacaaa ctgtctaatg aaattgaagg
      481 tttcgaaaga tgtctaaagc ttagtggcca catctatcgt ctgtcttctg acccttaaaa
      541 aaaaaaaaac aaagaataaa tgggatgttt cagaagagag ctatttaaaa ggaagagtgt
      601 tgcaaatggc ttcagaatct accaatggga agctagctag gagtcacgtg acaaaggggc
      661 ggcgtcagca gcagcagcag cagcaggtga ggagccggtc ctctgtcagc gagtgcgatg
      721 gcgacgactc cttcatcttc gaagccaacg aggcctggaa ggactttcac ggctctctcc
      781 tgggcttcta tgagaacggg gagctctgtg acgtcactct aaaggtcggc tcgaagctca
      841 tctcctgcca caagctggcg ctggcttgtg tcatccccta cttcagagcc atgtttcttt
      901 ctgaaatgtc tgaggctaag caggcgctga tcgagattcg ggactttgac ggcgatgccg
      961 tggaggactt ggtgaagttc gtctactctt cgcggctcac tctgacagtg gacaacgtcc
     1021 agcctctgct gtatgcagcg tgcatcctgc aggttgaact ggtggccaga gcttgctgcg
     1081 aatacatgaa gctacacttt catccctcca actgcctggc tgtgcgagcc tttgcggaga
     1141 gtcacaaccg aacagaccta atggacatgg cggaccagta tgcgtgcgag cactttactg
     1201 aagtggtaga gtgtgaggac ttcgtgagcg tgtccccaca gcacctgcac aagctcctct
     1261 cctccagcga cctcaacatc gacagcgaga agcaggtcta cagtgccgcc atcaagtggc
     1321 ttcttgccaa cccacagcat caccctaaat ggctggacga gacccttgcc caggtccgtc
     1381 tgccactctt gccagtggat ttcctcatgg gcgttgtggc aaaagagcag attgtcaagc
     1441 aaaatctgaa atgtagagac ctactggatg aagccagaaa ttaccacctt catttgagca
     1501 gtaaaccagt tcctgacttt gagtattcag tccgaactac cccgaggaag catactgctg
     1561 gtgtgctgtt ctgtgtgggt ggtcgaggtg gatctggtga cccctttcgt agtatcgaat
     1621 gctattctat caacacaaac agctggttct ttggaccaga aatgaacagc cgcaggaggc
     1681 atgtgggcgt gatctctgtg gaagggaaag tgtatgccgt gggcggccat gatgggaacg
     1741 agcacctagg cagcatggag atgtttgacc ctctcactaa caaatggatg gtgaaggcat
     1801 cgatgaacac caagaggcga ggaattgcct tggcctcctt agggggccca atatatgcga
     1861 ttggaggatt agatgacaac acttgcttca gtgacgtgga gagatacgac attgaatctg
     1921 accagtggag tacggtggcg ccaatgaaca ctccccgtgg aggtgtcggc tctgtggctt
     1981 taatcaacca tgtttacgca gtgggtggca acgatggcgt agcctccttg tccagtgtgg
     2041 aaaggtatca cccgcatctg gataagtggg tggaggtgaa ggagatgggc cagcggagag
     2101 ccggcaatgg tgttagtgag cttcacggct gcttatacgt tgttggtggt tttgatgata
     2161 attcccctct gagttcggtt gagcggtacg atcctcggag caacaagtgg gactatgtgg
     2221 cagcgctcac cactcccagg ggtggcgtag ggattgcgac ggtgatgggc aagatctttg
     2281 cagtcggagg ccacaacggc aatgcctacc tcaacacagt ggaggcgttc gaccctgtgc
     2341 tgaataaatg ggaactggtc ggacctgtgt ctcactgccg agctggtgcc ggtgtggccg
     2401 tgtgtgactg cttaactagc cagatccgag acgtaggtca tgggtccact aacgtggttg
     2461 actgtatgtg attaagtccc agcaacaagg atacagtgcc atctgatgga cgggaagacg
     2521 agcctttcaa catggcgcat ttgattgtga ccacagctac tgtctttgag tgtcagctgt
     2581 tgtaagtagg tctgtgggct gacggtgaga gctgctagtc acagagtgaa gtgagctgtt
     2641 tcctgcctca gcagacagtg agtaggctgg aagcagcctg tcagcccatt cttgcgctga
     2701 gagacgtttc atgtagtgcc aaaccttaaa atagctgttt attttgatga ataaaatgta
     2761 atttattgag ttttatctgt tctttttcct gaagaaacta acttcaggca gtagattttt
     2821 ttcccagagg agagagaagt ccactcatca acatgagaac ttgaggcctg ctcccttgag
     2881 gatcactcta catggtgctg gtgaatgtat gtcttgcttt ttgtctccag atggtgactt
     2941 tcagttcttg ggtgtttatg aagtagggaa aatgtttgtg tgtttctgag acattcttga
     3001 aaccacatta gtgtctgtaa gaaggccttg gcctccatgt ggagttttag aaccacagga
     3061 catagctgtg cctgcttcct caccaagtgt actggccgcc attcttttcc cattcgtgag
     3121 agtttcttgg tgatgaccgt ggcttggcat gagtgcagcg tccagtgaaa agactgagaa
     3181 ggatgtatga agcccatgcc cacctaggga ggttgtggag gctcctttaa ccttgttctt
     3241 ctgcttagtc gttgaatttg gaaccaggac ccattttctc ttactctgtc atttgtcgcc
     3301 gtcttgggtt tcctaattgt acaaagctga atttatttat tatcaggaca tgaatgcgtt
     3361 tttacaacat tcctttctgc agtatagtct gatgattagt tccagtttgt cattaatcaa
     3421 taaaatatgt tgctggtaaa aacagaaaaa aaa
//
LOCUS       NM_001437165            2247 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 2, mRNA.
ACCESSION   NM_001437165
VERSION     NM_001437165.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54680.1,
                                           SRR26643287.35239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000018.1  69725889-69725982
            95-246              JAXUCZ010000018.1  69726124-69726275
            247-374             JAXUCZ010000018.1  69732094-69732221
            375-474             JAXUCZ010000018.1  69732881-69732980
            475-621             JAXUCZ010000018.1  69735312-69735458
            622-807             JAXUCZ010000018.1  69736741-69736926
            808-963             JAXUCZ010000018.1  69740845-69741000
            964-1071            JAXUCZ010000018.1  69741592-69741699
            1072-2247           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2247
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..94
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            95..246
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            247..374
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1125
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 1"
                     /protein_id="NP_001424094.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MCSKTKMTEKTNPHPPLRPTESAALMRGCLRGLESVSFMEQMQR
                     IPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREPLKNLFFVLAERARGPNPRKR
                     HLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQ
                     GQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQD
                     SLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEI
                     LLFFYANKIL"
     misc_feature    532..978
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    532..978
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    646..747
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    646..747
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    775..864
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    775..864
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            375..474
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            475..621
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            622..807
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            808..963
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1071
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2247
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtaagg aaaccagggc tgggaaaatc
      121 tcgctgactc accacatttg gaggccaatc ccgaatcggt ggaacaacgc gcctcccgag
      181 agacccagga ctagcctcca gccccgaaac agcggttctt cacgtgacag tcaccccagg
      241 agccagggcc atctgacctc gaaaatgtgc tcaaaaacaa agatgacaga gaagacaaat
      301 ccccacccac ctctacgccc caccgaatca gctgctctga tgcgtggctg cctaagaggg
      361 ctggaatctg tcagtttcat ggaacaaatg cagagaatcc cgaaccagcc cctccccacc
      421 cctgcttctc agtccaagaa gaggaggaca ccactgtcat ctttcttttc caaggtctct
      481 tggaaactga ggttgcagaa gcgggaacct ttgaagaatc tgtttttcgt cttggcagaa
      541 agagcccggg gtcctaatcc tagaaagcgc catctagcaa tgagaggcct gggtatcttg
      601 gcccatgaag ctcctgacaa gcaggtgaga aagtataaga aagttatgct tgacctgctg
      661 gtacacgggc tgtatgatcc tgtgagttcc gaagtcattc atgagagtgt gaagacgctg
      721 actatcatgt tgggcaagat ccagggccaa cggctgggct ccttcttcat agacatcacc
      781 cttcagaccc ggaccctatt ggatgatgag gatgacagcg tgcgctactc agcctttgtc
      841 ctctttgggc agttggctgc atttgctggg cggaaatgga agaagttctt cacccaccag
      901 gtcaaccaga cccaagattc cctcctaagc catttgcagg acgaaagccc tcaggttgcc
      961 aaggcttgca caatggctgt tcaagcctgt gttccatacc tgaaacccag aaaggagcag
     1021 agtttccaaa gtgaagaaga ccagaagaac cgcaggcttt cccagcaact gagccactac
     1081 catccagaga tcctgctgtt cttctatgcc aataaaatcc tgtaggtcca gagcagcaga
     1141 gaaagcccac gggagtgccc tgccccggca tggaatttcc catctgtctc ataggatacc
     1201 tctttgactc tcgagtgatt gtaagagaaa agaggatgtc agagagcaac tgaaaaaaaa
     1261 atcaccctgg agtgcacgca aagtaaaatt ctatgcaagt gtgtgcacat acatgcacat
     1321 gactgtggag gtcagaggac gacctcactg ctgttcctaa ggcgtcatcc atctttccac
     1381 tgaaacagga tctttgactg gcctggggct tgcaggagct tagactaggc ttgatagcta
     1441 gtgagccagc tctggggtta taaccacagt ccatcgaacc aaccgttttt gactgtgcca
     1501 aattcaggcc cttataccta cttgtgctga ctaagccgtc tccccagccc agtagatgca
     1561 cacttcctta aaacatttaa catgcatgat gtcccaatcc ctcctttctc actccctctc
     1621 tgccaggtga cacacattta taatatgtaa cttctgaggc ttgggggaac aattgttacc
     1681 ttaaacattt ttaaactgta tttgtttttg atagtttgct atttgctacg gaccaggaga
     1741 ccaaggagct ggcttacaat gtgtctttaa tttcggatga tcttaaaatg tcatggtctt
     1801 aaaatcgtct ttaaaaagaa caacaaggaa aagaaatatt gttgaaaatc cactgaatga
     1861 tgataagtta cagaataaaa acagtaacat ttactgagaa tgcttacaac ttatttcggt
     1921 actgtggtgg tttggatgag cgaccctgca ggcttacgta tttgaatgct tggtcccttc
     1981 ttagtggaag tgtttaggag gggttagagg gtgtgtatat cactggagat ggaatttgag
     2041 acttcagaag cccaagcaag gccctgtctg tctgtctgtc tgtctgtctg tccgtctctt
     2101 attttgcctg cctactgtct acagatcaag acgtaaagct ctcagttact actctagcac
     2161 catgcctgtc tactcctacc atgatgataa tgaactggcc ttctaaaact ctaagccagc
     2221 cccaattaaa cgcttccttt tataaga
//
LOCUS       NM_001437175            2043 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 12, mRNA.
ACCESSION   NM_001437175
VERSION     NM_001437175.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77780.1,
                                           SRR26360186.1703029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-315             JAXUCZ010000018.1  69732881-69732980
            316-462             JAXUCZ010000018.1  69735312-69735458
            463-648             JAXUCZ010000018.1  69736741-69736926
            649-759             JAXUCZ010000018.1  69740890-69741000
            760-867             JAXUCZ010000018.1  69741592-69741699
            868-2043            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2043
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            216..315
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..921
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 6 is encoded by transcript variant 12;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 6"
                     /protein_id="NP_001424104.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MEQMQRIPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREP
                     LKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPV
                     SSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLDDLAAFAGRKWKKFFTHQV
                     NQTQDSLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSH
                     YHPEILLFFYANKIL"
     exon            316..462
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            463..648
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            649..759
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            760..867
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            868..2043
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccagtttca tggaacaaat gcagagaatc
      241 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      301 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      361 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      421 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca agcaggtgag aaagtataag
      481 aaagttatgc ttgacctgct ggtacacggg ctgtatgatc ctgtgagttc cgaagtcatt
      541 catgagagtg tgaagacgct gactatcatg ttgggcaaga tccagggcca acggctgggc
      601 tccttcttca tagacatcac ccttcagacc cggaccctat tggatgattt ggctgcattt
      661 gctgggcgga aatggaagaa gttcttcacc caccaggtca accagaccca agattccctc
      721 ctaagccatt tgcaggacga aagccctcag gttgccaagg cttgcacaat ggctgttcaa
      781 gcctgtgttc catacctgaa acccagaaag gagcagagtt tccaaagtga agaagaccag
      841 aagaaccgca ggctttccca gcaactgagc cactaccatc cagagatcct gctgttcttc
      901 tatgccaata aaatcctgta ggtccagagc agcagagaaa gcccacggga gtgccctgcc
      961 ccggcatgga atttcccatc tgtctcatag gatacctctt tgactctcga gtgattgtaa
     1021 gagaaaagag gatgtcagag agcaactgaa aaaaaaatca ccctggagtg cacgcaaagt
     1081 aaaattctat gcaagtgtgt gcacatacat gcacatgact gtggaggtca gaggacgacc
     1141 tcactgctgt tcctaaggcg tcatccatct ttccactgaa acaggatctt tgactggcct
     1201 ggggcttgca ggagcttaga ctaggcttga tagctagtga gccagctctg gggttataac
     1261 cacagtccat cgaaccaacc gtttttgact gtgccaaatt caggccctta tacctacttg
     1321 tgctgactaa gccgtctccc cagcccagta gatgcacact tccttaaaac atttaacatg
     1381 catgatgtcc caatccctcc tttctcactc cctctctgcc aggtgacaca catttataat
     1441 atgtaacttc tgaggcttgg gggaacaatt gttaccttaa acatttttaa actgtatttg
     1501 tttttgatag tttgctattt gctacggacc aggagaccaa ggagctggct tacaatgtgt
     1561 ctttaatttc ggatgatctt aaaatgtcat ggtcttaaaa tcgtctttaa aaagaacaac
     1621 aaggaaaaga aatattgttg aaaatccact gaatgatgat aagttacaga ataaaaacag
     1681 taacatttac tgagaatgct tacaacttat ttcggtactg tggtggtttg gatgagcgac
     1741 cctgcaggct tacgtatttg aatgcttggt cccttcttag tggaagtgtt taggaggggt
     1801 tagagggtgt gtatatcact ggagatggaa tttgagactt cagaagccca agcaaggccc
     1861 tgtctgtctg tctgtctgtc tgtctgtccg tctcttattt tgcctgccta ctgtctacag
     1921 atcaagacgt aaagctctca gttactactc tagcaccatg cctgtctact cctaccatga
     1981 tgataatgaa ctggccttct aaaactctaa gccagcccca attaaacgct tccttttata
     2041 aga
//
LOCUS       NM_001437168            2105 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 5, mRNA.
ACCESSION   NM_001437168
VERSION     NM_001437168.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.686711.1,
                                           SRR26360176.1907309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000018.1  69725889-69726123
            236-335             JAXUCZ010000018.1  69732881-69732980
            336-482             JAXUCZ010000018.1  69735312-69735458
            483-665             JAXUCZ010000018.1  69736744-69736926
            666-821             JAXUCZ010000018.1  69740845-69741000
            822-929             JAXUCZ010000018.1  69741592-69741699
            930-2105            JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2105
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..235
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    3..5
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     CDS             183..983
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 3 is encoded by transcript variant 5;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 3"
                     /protein_id="NP_001424097.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MLCWLQIPRGPSGFSFCSFMEQMQRIPNQPLPTPASQSKKRRTP
                     LSSFFSKVSWKLRLQKREPLKNLFFVLAERARGPNPRKRHLAMRGLGILAHEAPDKVR
                     KYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQGQRLGSFFIDITLQTRTLLD
                     DEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQDSLLSHLQDESPQVAKACTMA
                     VQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEILLFFYANKIL"
     misc_feature    381..467
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    381..467
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    393..836
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    393..836
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    501..608
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    501..608
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    633..710
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    633..710
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            236..335
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            336..482
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            483..665
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            666..821
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            822..929
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            930..2105
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtagtttca
      241 tggaacaaat gcagagaatc ccgaaccagc ccctccccac ccctgcttct cagtccaaga
      301 agaggaggac accactgtca tctttctttt ccaaggtctc ttggaaactg aggttgcaga
      361 agcgggaacc tttgaagaat ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc
      421 ctagaaagcg ccatctagca atgagaggcc tgggtatctt ggcccatgaa gctcctgaca
      481 aggtgagaaa gtataagaaa gttatgcttg acctgctggt acacgggctg tatgatcctg
      541 tgagttccga agtcattcat gagagtgtga agacgctgac tatcatgttg ggcaagatcc
      601 agggccaacg gctgggctcc ttcttcatag acatcaccct tcagacccgg accctattgg
      661 atgatgagga tgacagcgtg cgctactcag cctttgtcct ctttgggcag ttggctgcat
      721 ttgctgggcg gaaatggaag aagttcttca cccaccaggt caaccagacc caagattccc
      781 tcctaagcca tttgcaggac gaaagccctc aggttgccaa ggcttgcaca atggctgttc
      841 aagcctgtgt tccatacctg aaacccagaa aggagcagag tttccaaagt gaagaagacc
      901 agaagaaccg caggctttcc cagcaactga gccactacca tccagagatc ctgctgttct
      961 tctatgccaa taaaatcctg taggtccaga gcagcagaga aagcccacgg gagtgccctg
     1021 ccccggcatg gaatttccca tctgtctcat aggatacctc tttgactctc gagtgattgt
     1081 aagagaaaag aggatgtcag agagcaactg aaaaaaaaat caccctggag tgcacgcaaa
     1141 gtaaaattct atgcaagtgt gtgcacatac atgcacatga ctgtggaggt cagaggacga
     1201 cctcactgct gttcctaagg cgtcatccat ctttccactg aaacaggatc tttgactggc
     1261 ctggggcttg caggagctta gactaggctt gatagctagt gagccagctc tggggttata
     1321 accacagtcc atcgaaccaa ccgtttttga ctgtgccaaa ttcaggccct tatacctact
     1381 tgtgctgact aagccgtctc cccagcccag tagatgcaca cttccttaaa acatttaaca
     1441 tgcatgatgt cccaatccct cctttctcac tccctctctg ccaggtgaca cacatttata
     1501 atatgtaact tctgaggctt gggggaacaa ttgttacctt aaacattttt aaactgtatt
     1561 tgtttttgat agtttgctat ttgctacgga ccaggagacc aaggagctgg cttacaatgt
     1621 gtctttaatt tcggatgatc ttaaaatgtc atggtcttaa aatcgtcttt aaaaagaaca
     1681 acaaggaaaa gaaatattgt tgaaaatcca ctgaatgatg ataagttaca gaataaaaac
     1741 agtaacattt actgagaatg cttacaactt atttcggtac tgtggtggtt tggatgagcg
     1801 accctgcagg cttacgtatt tgaatgcttg gtcccttctt agtggaagtg tttaggaggg
     1861 gttagagggt gtgtatatca ctggagatgg aatttgagac ttcagaagcc caagcaaggc
     1921 cctgtctgtc tgtctgtctg tctgtctgtc cgtctcttat tttgcctgcc tactgtctac
     1981 agatcaagac gtaaagctct cagttactac tctagcacca tgcctgtcta ctcctaccat
     2041 gatgataatg aactggcctt ctaaaactct aagccagccc caattaaacg cttcctttta
     2101 taaga
//
LOCUS       NM_133423               3257 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 1, mRNA.
ACCESSION   NM_133423
VERSION     NM_133423.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced NM_133423.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF144731.1, SRR26360190.1179073.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-417             JAXUCZ010000014.1  21560488-21560589   c
            418-746             JAXUCZ010000014.1  21559484-21559812   c
            747-1179            JAXUCZ010000014.1  21558937-21559369   c
            1180-1269           JAXUCZ010000014.1  21556341-21556430   c
            1270-1323           JAXUCZ010000014.1  21555834-21555887   c
            1324-1418           JAXUCZ010000014.1  21555171-21555265   c
            1419-1527           JAXUCZ010000014.1  21553803-21553911   c
            1528-1645           JAXUCZ010000014.1  21553603-21553720   c
            1646-1730           JAXUCZ010000014.1  21550070-21550154   c
            1731-1897           JAXUCZ010000014.1  21548930-21549096   c
            1898-1980           JAXUCZ010000014.1  21546400-21546482   c
            1981-2017           JAXUCZ010000014.1  21545168-21545204   c
            2018-2081           JAXUCZ010000014.1  21545032-21545095   c
            2082-2144           JAXUCZ010000014.1  21544877-21544939   c
            2145-2279           JAXUCZ010000014.1  21543336-21543470   c
            2280-3257           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3257
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2504
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 1 is encoded by transcript variant 1; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 1"
                     /protein_id="NP_596914.2"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQR
                     SERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDG
                     DDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDS
                     GSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHE
                     KLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNL
                     AFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDW
                     ICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIH
                     KMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGY
                     LKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPG
                     IEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVV
                     SGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR"
     misc_feature    288..1310
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    390..392
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    639..641
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    645..647
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    723..725
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    729..731
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1218..1220
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1239..1241
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1245..1247
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1248..1250
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1254..1256
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1362..1772
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1362..1772
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1566..1568
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1599..1601
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1821..1985
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1929..1931
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    2139..2249
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2325..2501
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            316..417
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            418..746
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1323
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1418
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1527
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1645
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1730
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1897
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1980
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2017
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2081
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2144
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2279
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..3257
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagatggg gaacttaatg ttttagatga tattttgact gaagtaccag
      361 aacaggatga tgaactgtat aatccagaga gtgaacaaga taaaaatgag aaaaaaggat
      421 caaaaagaaa aagtgaaaga atggaatcta ttgacaccaa gcgacagaag ccttctatcc
      481 attcaagaca actgatttct aagccactaa gctcatctgt tagcaataat aaaagaatag
      541 ttagtacaaa aggaaagtcg gttacagaat ataaaaatga ggaatatcaa agatctgaaa
      601 ggaacaagcg tctagatgct gatcgaaaaa ttcgtctgtc aagcagttcc tctagagaac
      661 cttacaagag tcaaccagaa aaaccttgtc tacggaaaag ggattctgaa agaagggcca
      721 agtctcctac accagatggt tctgagagaa ttgggcttga agttgataga cgtgcaagca
      781 gatccagcca gtcttcaaag gaagagggga actctgagga gtatggctct gaccacgaga
      841 caggaagcag tgcttcttct gaacagggca acaacactga gaatgaggag gaaggagggg
      901 aagaagatgt agaggaagat gaagaggtag atgaagatgg agatgatgat gaggaagtgg
      961 atgaagatgc ggaggaggag gaggacgagg aagaagatga ggaggaggag gatgaggaag
     1021 aagaagagga agaggaagaa gaatatgaac aggatgagag agatcagaag gaagaaggga
     1081 atgattatga cacccgtagt gaggccagtg attctggttc tgagtctgtt tccttcacag
     1141 atggatctgt caggtctggt tcaggaacag atggatcaga tgagaaaaag aaggaaagga
     1201 agagagctcg aggcatatca cccattgtct ttgatagaag tggcagttct gcatcagagt
     1261 catatgcagg ttcagaaaag aagcatgaga aattatcatc ttccgttcgt gctgtccgaa
     1321 aagatcaaac cagtaaactc aaatatgtcc ttcaggatgc aagatttttc ctcataaaga
     1381 gtaacaacca tgagaatgtg tctcttgcca aagcaaaggg tgtatggtcc acattacctg
     1441 taaatgagaa gaaattaaat cttgcgttta gatctgcaag gagtgttata ttaatatttt
     1501 ctgtcaggga aagtggaaag tttcaaggtt ttgccagatt gtcatcagaa tcgcatcatg
     1561 gtggctctcc tatacattgg gtgcttccag caggaatgag tgctaaaatg cttggaggtg
     1621 tttttaaaat tgactggatt tgcaggcgtg aattaccctt tactaagtca gctcatctca
     1681 ccaatccctg gaatgaacat aagccagtaa agattggacg tgatggacag gaaattgaac
     1741 ttgaatgtgg aacccagctt tgtcttctgt ttccccctga tgaaagtatt gacttgtatc
     1801 agctcattca taaaatgcgt cacaagagaa gaatgcattc tcagcctcga tcaagaggac
     1861 gtccatcccg tcgagaacca gtccgggatg tgggaaggcg tcgaccagaa gattatgata
     1921 ttcataacag cagaaagaaa ccaaggattg actatccccc tgagtttcac cagagaccag
     1981 ggtatttaaa ggatccccga taccaggaag ttgacagttt cacaaatctt attcccaaca
     2041 gacgattttc aggagttcgc cgagatgtgt ttttaaatgg gtcctacaat gattatgtga
     2101 gggaatttca taacatggga ccaccgcctc cttggcaagg aatgcctcct tacccgggaa
     2161 tagaacagcc tccacaccat ccctactacc agcaccatgc cccgcctcct caagcccacc
     2221 ccccttactc aggacaccat ccggtaccac atgaagcaag atacagagat aaacgagtac
     2281 atgactatga tatgagggtt gatgatttcc ttcgccgcac acaagccgtt gtcagtggtc
     2341 ggagaagtag accccgagaa agagatcggg agcgagagcg agaccgccct agagataaca
     2401 gaagagatag agagcgagac agaggtcgtg atcgagaaag agagagagaa agaatatgtg
     2461 atcgggacag agaccgaggg gaaagaggtc gttatcgaag ataatgtgct ttttggaagc
     2521 actgactgaa gataaaaaat attgtatttt ttttgtgtgt gtttacaagt agtaaattta
     2581 ttttcagctg tctacttaaa gctcattgtg tagaaggatt tattatcttc tttgttccaa
     2641 gcatgcagta gaataagaac tggaaaactc agatccgcca aaaaatgcac agttgacagt
     2701 tgagttgaca cttttattgg ggcagaatgg aacagtccaa gaatgtagat attgattcat
     2761 tctccataaa tgttcttttt acagtgtatt catcctagag ttattttgtt tgtttgtttt
     2821 ccttcttttg gaccttggtc aatactgcca tagtattttg ctttgtgttt ctataggtag
     2881 ctgcacacgg ttcagtaaaa ataatgctgc tatcaagtat gcagatattg agtatgatgg
     2941 tttgactata tggcagtgtt gtagcagcct ctcggtttct cctcttccct cctttttttt
     3001 aaacctataa atccactttt tttttaagtc ttcaatgatg agagcaatat taagaagaca
     3061 ttgctatcta atttttaatc tttttaaata aaacgttcct atgttcagta gcatggtcga
     3121 tgctattgtt tagccttcct tccaaactgt acattggctt ggaatgttca gttttgcgtg
     3181 tgtggcagca gaagataacc ccacattcta cattgctact gttttgtatg aaataaattg
     3241 gtaaagattg acactaa
//
LOCUS       NR_199194                797 bp    RNA     linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 7, non-coding RNA.
ACCESSION   NR_199194
VERSION     NR_199194.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2606412.1,
                                           SRR26360181.908053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000009.1  21074406-21074500
            96-204              JAXUCZ010000009.1  21077810-21077918
            205-273             JAXUCZ010000009.1  21079517-21079585
            274-797             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..797
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     misc_RNA        1..797
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /product="ciliary microtubule inner protein 3, transcript
                     variant 7"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..95
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    87..128
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001437141.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            96..204
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            205..273
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            274..797
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccctcc cgagactccc cagatgcctc tggatcccta accaccagaa gttccatttt
       61 accatcaaag aggaaactga ccaaagatgt tgaaaatgct gtgtgaactt caactgatga
      121 tagcttagat acccatgagc ctctgcttca gcatcagaaa aacggggtaa acacctcatt
      181 tgtctgttag gagccttggc agagataata gacacaaaag atggatcacg cggttgtcac
      241 taccaaaagt ggactttgga gcgaacggaa aaggagtcac agaaatcctt aatccccggt
      301 caccggcaaa agacgacatc aggcagaaag gggaagaagg tgccgccgcc cacaccaaca
      361 ccattgtcac agaaatggaa acgggaccgc aaacagtctc tggagtcagc ttatgtcccc
      421 gtggtggtgg atcctcgcgg gcaggagcca gacagtagtt tcaggttcaa tttctacaac
      481 tcacagtatt ccaactctct caatcccttc tacaccctgc agaaacccac ctgtggttac
      541 ctgtaccaga gagaaactga ccacacacgg aaatgctttg gcattcctcc cgcaaacctg
      601 gtcttgtggc gcagcaccta ctaaatccaa ggcatctgga agtccccacc ctgcaccttc
      661 actctgtggt cctgggtccc agagggaaaa gtcattcatt cctggagaag cggcgtatac
      721 ctgggctagc caggtatgct gtgacagctg agggaggcct cttcccaata aacttcagtc
      781 cttctttttt tctggca
//
LOCUS       NR_199195                907 bp    RNA     linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 8, non-coding RNA.
ACCESSION   NR_199195
VERSION     NR_199195.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.466807.1,
                                           SRR26360181.2206300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000009.1  21079157-21079391
            236-383             JAXUCZ010000009.1  21079517-21079664
            384-907             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..907
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     misc_RNA        1..907
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /product="ciliary microtubule inner protein 3, transcript
                     variant 8"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..235
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    112..327
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001437142.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated mRNA decay (NMD)
                     candidate"
     exon            236..383
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            384..907
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctctact agaattcagc tgaggtgaac ctacatttcc tgagctctca cttctgaatg
       61 tgtcaaggcc ctcgaggttt ggagtaaaga aacaggattt agggagcttc tatgtcgcga
      121 gtaaggggcc ttcctagaga tgggaagcaa gggagtcgct tctgccctgc gctgattgga
      181 ttcttgaatg atttgaaggt gaccaaaaga aaggctagag ggaccggaag cagaaataat
      241 agacacaaaa gatggatcac gcggttgtca ctaccaaaag tggactttgg agcgaacgga
      301 aaaggcgaga gcttgaaggg agagtgactc cgaaggtcac ttgggacggc tcttcaggag
      361 aaagagaatg aagacatgat agtgagtcac agaaatcctt aatccccggt caccggcaaa
      421 agacgacatc aggcagaaag gggaagaagg tgccgccgcc cacaccaaca ccattgtcac
      481 agaaatggaa acgggaccgc aaacagtctc tggagtcagc ttatgtcccc gtggtggtgg
      541 atcctcgcgg gcaggagcca gacagtagtt tcaggttcaa tttctacaac tcacagtatt
      601 ccaactctct caatcccttc tacaccctgc agaaacccac ctgtggttac ctgtaccaga
      661 gagaaactga ccacacacgg aaatgctttg gcattcctcc cgcaaacctg gtcttgtggc
      721 gcagcaccta ctaaatccaa ggcatctgga agtccccacc ctgcaccttc actctgtggt
      781 cctgggtccc agagggaaaa gtcattcatt cctggagaag cggcgtatac ctgggctagc
      841 caggtatgct gtgacagctg agggaggcct cttcccaata aacttcagtc cttctttttt
      901 tctggca
//
LOCUS       NM_001437056            5828 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus hyaluronan synthase 3 (Has3), transcript variant
            1, mRNA.
ACCESSION   NM_001437056 XM_006255561
VERSION     NM_001437056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5828)
  AUTHORS   Bart,G., Vico,N.O., Hassinen,A., Pujol,F.M., Deen,A.J., Ruusala,A.,
            Tammi,R.H., Squire,A., Heldin,P., Kellokumpu,S. and Tammi,M.I.
  TITLE     Fluorescence resonance energy transfer (FRET) and proximity
            ligation assays reveal functionally relevant homo- and heteromeric
            complexes among hyaluronan synthases HAS1, HAS2, and HAS3
  JOURNAL   J Biol Chem 290 (18), 11479-11490 (2015)
   PUBMED   25795779
REFERENCE   2  (bases 1 to 5828)
  AUTHORS   Torronen,K., Nikunen,K., Karna,R., Tammi,M., Tammi,R. and Rilla,K.
  TITLE     Tissue distribution and subcellular localization of hyaluronan
            synthase isoenzymes
  JOURNAL   Histochem Cell Biol 141 (1), 17-31 (2014)
   PUBMED   24057227
REFERENCE   3  (bases 1 to 5828)
  AUTHORS   Rauhala,L., Hamalainen,L., Salonen,P., Bart,G., Tammi,M.,
            Pasonen-Seppanen,S. and Tammi,R.
  TITLE     Low dose ultraviolet B irradiation increases hyaluronan synthesis
            in epidermal keratinocytes via sequential induction of hyaluronan
            synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent
            protein kinase II (CaMKII) signaling
  JOURNAL   J Biol Chem 288 (25), 17999-18012 (2013)
   PUBMED   23645665
  REMARK    GeneRIF: Data indicate that p38 and Ca(2+)/calmodulin-dependent
            protein kinase II pathways were found to be involved in the
            UVB-induced up-regulation of Has2 and Has3 expression.
REFERENCE   4  (bases 1 to 5828)
  AUTHORS   Ormiston,M.L., Slaughter,G.R., Deng,Y., Stewart,D.J. and
            Courtman,D.W.
  TITLE     The enzymatic degradation of hyaluronan is associated with disease
            progression in experimental pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 298 (2), L148-L157 (2010)
   PUBMED   19915162
REFERENCE   5  (bases 1 to 5828)
  AUTHORS   Mrabat,H., Beagle,J., Hang,Z., Garg,H.G., Hales,C.A. and Quinn,D.A.
  TITLE     Inhibition of HA synthase 3 mRNA expression, with a
            phosphodiesterase 3 inhibitor, blocks lung injury in a septic
            ventilated rat model
  JOURNAL   Lung 187 (4), 233-239 (2009)
   PUBMED   19572173
  REMARK    GeneRIF: Inhibition of HA synthase 3 mRNA expression, with a
            phosphodiesterase 3 inhibitor, blocks lung injury in a septic
            ventilated rat model.
REFERENCE   6  (bases 1 to 5828)
  AUTHORS   Karvinen,S., Pasonen-Seppanen,S., Hyttinen,J.M., Pienimaki,J.P.,
            Torronen,K., Jokela,T.A., Tammi,M.I. and Tammi,R.
  TITLE     Keratinocyte growth factor stimulates migration and hyaluronan
            synthesis in the epidermis by activation of keratinocyte hyaluronan
            synthases 2 and 3
  JOURNAL   J Biol Chem 278 (49), 49495-49504 (2003)
   PUBMED   14506240
  REMARK    GeneRIF: belongs to the targets of keratinocyte growth factor in
            keratinocytes, and support the idea that enhanced hyaluronan
            synthesis acts an effector for the migratory response of
            keratinocytes in wound healing
REFERENCE   7  (bases 1 to 5828)
  AUTHORS   Pasonen-Seppanen,S., Karvinen,S., Torronen,K., Hyttinen,J.M.,
            Jokela,T., Lammi,M.J., Tammi,M.I. and Tammi,R.
  TITLE     EGF upregulates, whereas TGF-beta downregulates, the hyaluronan
            synthases Has2 and Has3 in organotypic keratinocyte cultures:
            correlations with epidermal proliferation and differentiation
  JOURNAL   J Invest Dermatol 120 (6), 1038-1044 (2003)
   PUBMED   12787132
  REMARK    GeneRIF: Epidermal hyaluronan synthesis, controlled by epidermal
            growth factor and transforming growth factor beta through changes
            in expression of Has2 and Has3, correlates with epidermal
            proliferation, thickness, and differentiation.
REFERENCE   8  (bases 1 to 5828)
  AUTHORS   Oishi,Y., Kato,H. and Noguchi,T.
  TITLE     Dietary protein as a potent regulator of the hyaluronan synthase
            gene in rat skin
  JOURNAL   Biosci Biotechnol Biochem 67 (4), 736-742 (2003)
   PUBMED   12784612
  REMARK    GeneRIF: protein malnutrition has a primary impact on the gene
            expression of Has2 and Has3, which leads to the reduction of
            hyaluronan content and to disfunction of the skin
REFERENCE   9  (bases 1 to 5828)
  AUTHORS   Itano,N., Sawai,T., Yoshida,M., Lenas,P., Yamada,Y., Imagawa,M.,
            Shinomura,T., Hamaguchi,M., Yoshida,Y., Ohnuki,Y., Miyauchi,S.,
            Spicer,A.P., McDonald,J.A. and Kimata,K.
  TITLE     Three isoforms of mammalian hyaluronan synthases have distinct
            enzymatic properties
  JOURNAL   J Biol Chem 274 (35), 25085-25092 (1999)
   PUBMED   10455188
REFERENCE   10 (bases 1 to 5828)
  AUTHORS   Hoock,T.C., Peters,L.L. and Lux,S.E.
  TITLE     Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate
            with mouse macrophage lysosomes
  JOURNAL   J Cell Biol 136 (5), 1059-1070 (1997)
   PUBMED   9060470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006255561.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.52876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000019.1  51678790-51678905
            117-755             JAXUCZ010000019.1  51681753-51682391
            756-857             JAXUCZ010000019.1  51685050-51685151
            858-5828            JAXUCZ010000019.1  51686069-51691039
FEATURES             Location/Qualifiers
     source          1..5828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..5828
                     /gene="Has3"
                     /note="hyaluronan synthase 3"
                     /db_xref="GeneID:266805"
                     /db_xref="RGD:628656"
     exon            1..116
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1781
                     /gene="Has3"
                     /EC_number="2.4.1.212"
                     /codon_start=1
                     /product="hyaluronan synthase 3"
                     /protein_id="NP_001423985.1"
                     /db_xref="GeneID:266805"
                     /db_xref="RGD:628656"
                     /translation="MPVQLTTALRVVGTSLFALVVLGGILAAYVTGYQFIHTEKHYLS
                     FGLYGAILGLHLLIQSLFAFLEHRRMRRAGRPLKLHCSQRRRSVALCIAAYQEDPEYL
                     RKCLRSAQRIAFPNLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAG
                     EGETEASLQEGMERVRAVVWASTFSCIMQKWGGKREVMYTAFKALGNSVDYIQVCDSD
                     TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQS
                     YFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKY
                     TARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPF
                     FLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSS
                     LLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSE
                     TELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV"
     misc_feature    375..1211
                     /gene="Has3"
                     /note="Hyaluronan synthases catalyze polymerization of
                     hyaluronan; Region: GT2_HAS; cd06434"
                     /db_xref="CDD:133056"
     misc_feature    375..1211
                     /gene="Has3"
                     /note="Hyaluronan synthases catalyze polymerization of
                     hyaluronan; Region: GT2_HAS; cd06434"
                     /db_xref="CDD:133056"
     misc_feature    762..770
                     /gene="Has3"
                     /note="DXD motif [active]"
                     /db_xref="CDD:133056"
     misc_feature    762..770
                     /gene="Has3"
                     /note="DXD motif [active]"
                     /db_xref="CDD:133056"
     exon            117..755
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..857
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..5828
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagtcggag cgcccggcgg caccgtggaa gcagcgcgcg gctgcgggag ccggaggagg
       61 ggcatggagc cgccgcgggc ctgctgagca ccggagcgcg ggcagcgggc ggcacgatgc
      121 cggtgcagct gactacagcc cttcgtgtgg tgggcaccag tctgtttgcc ctggtagtgc
      181 tggggggcat cctggcagcc tatgtcacag gctaccagtt tatccacacg gaaaagcact
      241 atctgtcctt cggcctctac ggtgccatcc tgggtctgca tctgctcatc cagagcctgt
      301 ttgccttcct ggagcaccgt cgcatgcgca gggcagggcg cccactgaag ctgcactgct
      361 ctcagagacg gcgttcggtg gcactctgca tcgctgccta ccaagaggac cctgagtact
      421 tgcgcaagtg ccttcgctca gctcagcgca ttgccttccc aaacctcaag gtggtcatgg
      481 tagtggatgg caatcgccag gaagatgcct acatgctgga catcttccat gaggtcctgg
      541 gtggcactga gcaagctggc ttctttgtgt ggcgtagcaa tttccatgag gcgggtgaag
      601 gagagacaga ggccagcttg caggaaggca tggagcgtgt tcgagctgtg gtgtgggcca
      661 gcaccttctc atgcatcatg cagaagtggg ggggcaagcg tgaagtcatg tacacagctt
      721 tcaaggccct tggcaactca gtggactaca tccaggtgtg tgactctgac actgtgctgg
      781 acccagcctg caccattgag atgcttcggg tcttggagga agatccccaa gtaggaggtg
      841 ttggaggaga tgtccaaatc ctcaacaaat acgattcatg gatctccttc ctgagcagcg
      901 tgaggtactg gatggccttc aacgtggagc gggcctgcca gtcctacttt ggctgtgtgc
      961 agtgtattag tgggcctctg ggcatgtacc gcaacagcct ccttcagcag ttcctggagg
     1021 actggtacca tcagaagttc ctaggcagca agtgcagctt tggggatgat cggcacctta
     1081 ccaaccgagt cctgagtctt ggctaccgga ctaagtatac agcacgctcc aagtgcctca
     1141 cagagacccc cactaagtat ctccgatggc tcaaccagca gacccgctgg agcaagtctt
     1201 actttcggga gtggctctac aactctctgt ggttccataa gcaccacctg tggatgacct
     1261 atgagtcagt ggtcacaggc ttcttcccct tcttcctcat cgccacagtc atacaacttt
     1321 tctaccgtgg ccgcatctgg aacattctcc tcttcctact aacggtgcag ctggtgggca
     1381 ttatcaaggc tacctatgcc tgcttcctcc gaggcaatgc agagatgatc ttcatgtccc
     1441 tctactccct tctctatatg tccagcctgc tgccagccaa gatctttgct attgctacca
     1501 tcaacaagtc tggctggggc acttctggca ggaaaaccat tgtagtgaac ttcattggcc
     1561 taatccctgt gtccatctgg gtggcagttc ttctaggggg gttagcctac acagcttatt
     1621 gtcaggacct gttcagtgag actgagctag ccttcctggt ctctggggcc atcttgtatg
     1681 gctgctactg ggtggccctc ctcatgctgt atttggccat tattgcccgg aggtgtggga
     1741 aaaagccaga acagtatagc ctggcttttg ctgaggtgtg atagaacctt caagtaaagt
     1801 gggaaatgtg caatgggtaa gggagggaag gggaatggaa aagaaggggt gggagggagg
     1861 agggcgtgtt gtgttctagt ttcatggctg ataggaccaa tgtgaaaagc gaagactagt
     1921 gactggagtg gtctgggtgg cactggttct gtaggctcag ggcagagaga cttgtatgtc
     1981 acttggctgc ttgcccttgc acaggtagtg aactcttgag aatcttactt ccttctggga
     2041 actatagagg acccagaagt atgctaaact aagtgctaaa ctccatcctg tgtcaacttc
     2101 tgatacagaa gcaagcaatg acagcccata gacagtgtct tcctccccat gtgagcatga
     2161 cgagctgtag gagttgttac tgtccagcct ggccggctgg tgtccccttc cctaactcca
     2221 attagccatc aatgcattaa gattgtgcct gagataacaa ggctggaaag cctgaccttt
     2281 ggtcaaaaaa cagggtctaa gaagtggtgc tttatgtaat taatatattc cactccacat
     2341 gaaaacatcc cagggatgag ccaagacacc aggagtaagt acttagtttg gtggggtttt
     2401 tttttgtttt tgtttttgtt tttgtttttt gttttttttg ggggggtggg gtgggaaggg
     2461 ttgcacatta caaaggaaag tttggccagt tgtggtgcat gtgtgtaatc taagcactta
     2521 gaagagatca gaggttcaac gttaggttgg actacatgag attctaactg tctcatacaa
     2581 aaatagtttg acaggaggat caaagatggt cgtggtgcta aaaaccgtgg atgccttgga
     2641 ctgaatgtgt tccaactgaa aactgcttgg tcttttacaa aattcccaat tgtcaagaga
     2701 acttgctggg cagattggat gttttagcca tctaccagaa agactcaact ccaatggatt
     2761 aacaagtctt taccggctcg ttcacacctg aatgcctctc agattcagct cgcatctgag
     2821 ttagacatcc tcctcaatat ttcattctct tcaaaggcac gtcgttctta gttgttttct
     2881 agtggggaaa gcagcagtta cctccatttc catgggcaca ttccttcaca tggcagagaa
     2941 cagacttaca aggctgttcc ccacatgcat ggagagagca gcctccaacc gcactgttcc
     3001 tgccttagga ctggtcagta cctcagcagc tggttagcat gtgtgacctt ctcgacaatc
     3061 attcccaaag gaaagcttcc tggtgttgcc caaatgaacc ctcaaatcca agttatctct
     3121 gagagcatcc attctcagtg gcttctccaa ggacttctac ggccaggtag tggatgatcc
     3181 tccatttgct gctgcagtcc agaaaccaaa ccaggagctg gaactggtcc aacagtcttc
     3241 agtccgctta cacccctcat ggctgcttga ctttcccgtt tcttttgagg aatgatgaga
     3301 agcattcata ctattttgaa gtcaagacca gacgctgttt ttggatttga aacctggggt
     3361 catgactaag cctttgactt taggggttgc ttatcattat tctcagaggg gccagccaac
     3421 ccctcagaac ctacagagcg agagcagtgt acacaggtgc ttcctgcaaa ggaatgaagt
     3481 gcactccaga cctcggatgg gcaagctctt gtactcccct ttctcttatg gacaaaaggg
     3541 tttttcccag tgtagctaac agttgccaca gcacacaaag ctcaagtttc tagtaaaact
     3601 gctggctgat gtgaagctca actcatggtg gttgggaagc agcatatttg tcagaggcag
     3661 ttgttctggg tccttctgtt aagaagtgaa ctattcaagc acgacagtgg agacaatcca
     3721 gtcagctaac ctcagagctc aggctgaggg cttgtttctc ttcaacttta cttgaaggtt
     3781 gcaggacaat ggactccgga tggaaactgg ttatccacca tcagctcttc tgccatgcac
     3841 tgtggtcaac tctcctcaga ttaaaacgca ggtacagtag tgagcttaca acacttgacc
     3901 tcggctggat ttcctaattt attttataac ttttcagcag caaagctaag ctgggctacg
     3961 gctatatccc tgtttcctgc aagggaagag cctttatata attagactca ttttggtttt
     4021 tcctcattga caatttcagc ttcttttgta ttatttctac aataatttgt aaatatttat
     4081 ttttaacctg cttttttatt aagtaaggag gaaactttat ttaacattaa gggtgggagg
     4141 gagtcagaag ggaggtggct ttacttgggg ataatactca tatcatgctc ttggcacagc
     4201 cactgagcac agtgcacagg cctcatgcct cttaagcaaa gtcacagtgt acatgtgagc
     4261 agctggagct catctctccc gaaagccttt atctgctgtt ctacccttgc ctatgccctt
     4321 caaagtccag gaggtgttcg tgttcctcca ggttaccaga caggttatag gaattcctca
     4381 taaagtgtag aactctacca gaacccttct cagaatgatc cttctgcttc acgatctctg
     4441 ccacctttct aattgttctt acaaaagctg tagtcagtgc aagtcccaca accaatgtcc
     4501 cttagccacc ccacccccag cttttgcagc ttcagctctg ccttgtcctt ctgcacctct
     4561 gggactctga tagcagagtc cccctgctgt cattctcctc cctgatgtcc atgttcttca
     4621 ctccagcatc atctagtggg gatgcaagct gacgagaaca gctcttcttt ttccaggacc
     4681 acctctgcac tctgggtagt cagtgctgac ctttgcccag cagtggaagc ctagatccct
     4741 tcctgcatct aatgctcaag aggctgtagt catcctctag caccaccgcc ccgagagtga
     4801 gacactagag gtgagctgag gccctgctga acttgtagtt gcaggataac ccagttctct
     4861 gccaattctc attcatgagg ccattggtgg gatcatccta gttcatatgg aaggtgtcta
     4921 gcctgttcct ccccagttcc ccatcttatt tagctagcaa atggcaaagc ttctgttgtg
     4981 ccaagaccag cagcataagg cggctgttag agcagttcca ttcttcttgg ccaacatttt
     5041 atgcaccagg ttcattcacc agcagcacat tttcttcctc ttgcaatact ccttctgtcc
     5101 tcaaaggtaa acgtcagtca gcctctcctt ggaattaatg acgtgcttct cagtgaggcc
     5161 ctataggtct caagcaccaa acatccgtgt gctgatgcct aacttttggt ctatctcctc
     5221 caacagctta gtcctcttct ctgccaagac ctgtagcccc tcaccatcca tcccagctgt
     5281 ggtgttccca gggccggggt catcctcccc taacttctgg cttaggagtg agtgccttcc
     5341 ttgtggctct tcttgtggcc atggagattg actttggata ttacaagtcc ctctttctta
     5401 acaatgactt tcaagagttt caacctcaat ttggctggaa ctgactgtct aaaagagcat
     5461 ctcctgagcc aaatgggccc cgatactttg tagctgccca gaatactgtg cagtgccatc
     5521 agagacctga atttccatca ccccagagcc ctacctgttg tccactcaga tgccatcctg
     5581 gtgctgtttt gtatcttaat gttctgtggc agcttgactc gctagaacta aactggcctc
     5641 actgggctac aaaagccctg atgacacaaa acacaatttt gggtgacaag gcagctgcta
     5701 tctggttgct ggcagccatg agcagctgct tctggcactg ttgttttcat tgcccttgga
     5761 gactggcttt tttgttgttt tcaggtcaag aattttttat tgcacttatc aaaataaaaa
     5821 ttcttacg
//
LOCUS       NM_001437072            5321 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1),
            transcript variant 1, mRNA.
ACCESSION   NM_001437072 XM_006239032
VERSION     NM_001437072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5321)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5321)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5321)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5321)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5321)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5321)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5321)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5321)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5321)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5321)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006239032.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.16251.1,
                                           SRR26643297.20301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  148121254-148121355
            103-476             JAXUCZ010000005.1  148126203-148126576
            477-545             JAXUCZ010000005.1  148153724-148153792
            546-654             JAXUCZ010000005.1  148171088-148171196
            655-833             JAXUCZ010000005.1  148172129-148172307
            834-1000            JAXUCZ010000005.1  148181206-148181372
            1001-1271           JAXUCZ010000005.1  148183570-148183840
            1272-1365           JAXUCZ010000005.1  148195258-148195351
            1366-1467           JAXUCZ010000005.1  148197680-148197781
            1468-1619           JAXUCZ010000005.1  148200975-148201126
            1620-1758           JAXUCZ010000005.1  148203568-148203706
            1759-1902           JAXUCZ010000005.1  148205552-148205695
            1903-2199           JAXUCZ010000005.1  148206678-148206974
            2200-2436           JAXUCZ010000005.1  148208059-148208295
            2437-2704           JAXUCZ010000005.1  148218465-148218732
            2705-2834           JAXUCZ010000005.1  148219783-148219912
            2835-2969           JAXUCZ010000005.1  148221617-148221751
            2970-3107           JAXUCZ010000005.1  148225153-148225290
            3108-3233           JAXUCZ010000005.1  148228732-148228857
            3234-3355           JAXUCZ010000005.1  148229514-148229635
            3356-3548           JAXUCZ010000005.1  148231206-148231398
            3549-5321           JAXUCZ010000005.1  148236696-148238468
FEATURES             Location/Qualifiers
     source          1..5321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5321
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..102
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Pum1"
                     /note="upstream in-frame stop codon"
     exon            103..476
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3680
                     /gene="Pum1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pumilio 1; pumilio homolog 1"
                     /codon_start=1
                     /product="pumilio homolog 1 isoform 1"
                     /protein_id="NP_001424001.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAAT
                     LGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGA
                     SQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALV
                     VNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLG
                     TQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLG
                     ATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSSS
                     PGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSA
                     SSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEF
                     SQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQK
                     LALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGHVLKCVKDQNG
                     NHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEE
                     LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCV
                     THASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKI
                     RPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     misc_feature    2640..3611
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    2640..3611
                     /gene="Pum1"
                     /note="Pumilio-family RNA binding domain; Region: Pumilio;
                     cd07920"
                     /db_xref="CDD:153420"
     misc_feature    order(2808..2813,2820..2822,2916..2921,2928..2930,
                     3033..3035,3042..3044,3138..3143,3150..3152,3237..3242,
                     3246..3251,3258..3260,3345..3350,3354..3359,3366..3368,
                     3474..3479,3483..3488,3495..3497,3585..3587,3594..3596)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     misc_feature    order(2808..2813,2820..2822,2916..2921,2928..2930,
                     3033..3035,3042..3044,3138..3143,3150..3152,3237..3242,
                     3246..3251,3258..3260,3345..3350,3354..3359,3366..3368,
                     3474..3479,3483..3488,3495..3497,3585..3587,3594..3596)
                     /gene="Pum1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:153420"
     exon            477..545
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..833
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1000
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1271
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1467
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1619
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1758
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1902
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2199
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2436
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2704
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2834
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2969
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3107
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3233
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3355
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3548
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..5321
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc ggcgagcgaa
       61 gatcgggggg ccggaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg
      121 ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga
      181 aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag
      241 ggtcgcaagc gcagccacag ccagctgcaa atcaggctct tgcagctggg acacactcca
      301 gccctgtccc aggatccata ggagttgcag gccgttccca ggacgacgct atggtggact
      361 acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtggt ggaggcggct
      421 ataatactag caaacatcga tggcctacag gggataacat tcatgcagaa caccaggtgc
      481 gctctatgga tgaattaaat catgattttc aagcacttgc tctggaaggg agagctatgg
      541 gcgagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac
      601 caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt
      661 cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg
      721 aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg
      781 agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa
      841 gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt gcgtttgatg
      901 gagataagct aggagatttg aaggaggagg gagatgtgat ggacaagacc aatggtttgc
      961 cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc
     1021 agagctctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag
     1081 cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc
     1141 agagtgtccc cttggacccc atggaacatg tgggcatgga gcctctgcag tttgattatt
     1201 caggcacgca ggtacctgtg gactcagcag cagcaacagt gggacttttt gactacaatt
     1261 ctcaacaaca gctattccaa agacccaatg cgcttgctgt tcagcagttg acagctgccc
     1321 agcagcagca atatgcactt gcagcagccc accagcctca catcggttta gctcccgctg
     1381 cgtttgtccc caacccatac atcatcagcg ctgctccccc agggacggac ccctacacag
     1441 ctggattggc tgcagcagcg acactcggcc cagctgtggt ccctcaccaa tattatggag
     1501 tcacgccatg gggtgtctat cctgctagtc ttttccagca acaagctgct gcagctgcag
     1561 cagcaacaaa ttcagctact cagcagagtg ccccacaggc ccagcaggga cagcagcagg
     1621 ttcttcgtgg aggagctagc cagcgtcctt tgaccccaaa tcagaaccag cagggacaac
     1681 aaacagatcc ccttgtagca gctgcagcag tgaactctgc tcttgccttt ggacaaggat
     1741 tggctgcagg tatgccaggt tatccagtct tggcacctgc tgcttactat gaccaaactg
     1801 gtgcccttgt ggtgaatgca ggggcaagaa atggcctcgg agctccagtt cggcttgttg
     1861 ctccagcccc agtcatcatt agctcctcag ctgcacaagc agctgttgca gcggctgcag
     1921 cttcagcaaa tggagcagcc ggtggtcttg caggaactac aaatggacca tttcgacctt
     1981 taggcaccca gcagccccag ccccagcccc agcagcagcc cagtaacaat ctggcttcca
     2041 gctctttcta tggcaacaac tctctgagca gtaactccca gagcagctcc ctcttctctc
     2101 agggctccgc ccagcctgcc aacacgtcct tgggattcgg aagcagcagt tcccttggtg
     2161 ccaccctagg atcggccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca
     2221 gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca
     2281 gcttggcccc cattggacac agtttttata acagccttag cttttcctcc tctcctggac
     2341 ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc
     2401 tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaac ggcagtggaa
     2461 gatacatctc tgctgctcct ggtgccgaag ccaagtaccg cagtgcgagc agtgcctcca
     2521 gccttttcag ccccagcagc accctttttt cttcctctcg tttgagatac ggaatgtctg
     2581 atgttatgcc ctctggcagg agcagacttc tggaagactt tcgaaacaac cggtacccta
     2641 atttacaact gcgggagatt gccgggcata taatggaatt ttcccaagac cagcatggtt
     2701 ctagattcat tcagctgaaa ctagagcgag ccacagcagc tgagcgccag cttgtcttca
     2761 acgaaatcct gcaggctgcg taccaactta tggtggatgt gtttggaaat tacgtcattc
     2821 agaagttctt tgaatttggc agccatgaac agaagctggc tttggctgaa cggattcgag
     2881 gccacgtcct atcattggca ctgcagatgt atggctgccg agtcatccag aaagctttgg
     2941 aatttattcc ctcagaccag caggtaatta acgagatggt gcgggagcta gatggccatg
     3001 tcctgaagtg tgtgaaagac cagaatggca accatgtggt tcagaagtgc attgaatgtg
     3061 tacagcccca gtctttgcag ttcatcatcg atgcattcaa ggggcaggtg tttgctttgt
     3121 ctacgcaccc atatggctgt agggtgatcc agaggatcct ggaacactgt ctccccgacc
     3181 agaccctccc tatcctggag gagcttcacc agcacacgga gcagctcgtg caggatcagt
     3241 atggaaatta tgtaatccaa catgtcctgg agcatggtcg tcctgaggat aaaagcaaaa
     3301 ttgtagcaga gatccgaggc aatgtacttg tattgagtca gcacaaattc gcaagcaatg
     3361 ttgtggagaa gtgtgtcact cacgcctcac gtacagagcg tgctgtgctc attgatgagg
     3421 tatgcaccat gaatgacggt ccccacagtg ccttatacac catgatgaag gatcagtatg
     3481 ccaattatgt ggtccagaag atgatcgatg tggctgagcc ggggcagcgg aagattgtca
     3541 tgcacaagat ccggccacac atcgcgactc ttcggaagta cacctatggc aagcacatcc
     3601 tggccaagct tgagaagtac tacatgaaga atggtgtgga cttggggccc atttgtggtc
     3661 cccctaatgg gatcatctga gcagtgcacc catccctgtc ccgctgacct cactgaccct
     3721 ggcagatcca accagcaacc agagatgccc agctcagagt cgaaagtggg cgatggttgc
     3781 tccgggattg ctccctcctc caaaaatgga atcggatcca cttgtggaaa ggcctttgta
     3841 aatttcattt tattacacat aacatgtact aattattttt tttaattgac taattgccct
     3901 gctgtttact ggtgtatagg aacttgtaca taggtaatca gtgtacatga gaggccacat
     3961 gctttgttca atgttgtatc tatattccac atgtggacac tttcagggtg gttggtttaa
     4021 caaaaaaagt tttaaaaaaa gacaaaaaaa ggtttttaac tcatttgcct tgtggcaagt
     4081 tttgcaaata gctcttcccc accccatttt attaaaaaaa gaaacctgag aaatttgaat
     4141 tttagttaaa taatctcaaa ctggcattta acactgttta taaaatatat atatatatat
     4201 acatatatac atatgaaatg ggaacgtttc cgagttgcta aagcatcagc ctgtgatacg
     4261 gagtttatga cgctctttgg agatgacctc atgctgaggg aggtggtagc tgcagatcca
     4321 ggaggagcgg gaagcacaga gacaggccgg aggccagtgg gcatggccac ttgctctatg
     4381 ggttgccttc tgtgaacact gggaagcaga atctgattat ctagcatgag agaacccagc
     4441 tctgctcctg gtctggcttc tatagataca tagtgtatac ttgtgtagac tttgcatata
     4501 tacggatttg tagtattttc ctgttttgat gtctaatctg tatctataat gtaccctagt
     4561 agtcggacat acttttgatt gtacaattgt acatttgtat acctgtaatg taaatgtgga
     4621 gaagtttgaa tcaacatgaa cacgtttttg gtaagaagag aaccggccag cccgtgcact
     4681 ctgtatatcc caccttttat ggttgtagca gatagtgttg tatattgtaa attgtaattt
     4741 caaacagaag taaatttttt tcttttgaag gaataaatgt tctttataca gcctagttaa
     4801 tgtttaaaaa gaaaaaatag cttggtttat ttgtcagcta gtcaagacgg tagtgagagc
     4861 ctttctaaat gttacttcag atgattcagt tcacactagt gttccttttt ttttttttat
     4921 cctaagaaaa ggtaatgttt cgcttatttt gtgacagtca aaaggatgtg cagaagtttc
     4981 gcctgcccct tccctgctca ccacctcccc ttgtaaagtg actcaccctc cgttttgtac
     5041 agatgagctg tattttgcat tttgtctact tgtaagtgaa tgtaacatac tgtcaatcct
     5101 cgtttgaata tagactgtaa cactacacgg tgtacatttc cagagccttg tgtatatttc
     5161 caatgaactt tttgcaagca cacttgtaac catatgtgta taattaacaa acctgtgtat
     5221 gcttatgcct gggcaactat tttttgtaac tcttgtgtag attgtctcta aacaatgtgt
     5281 gatctttatt ttgaaaaaaa tacagaactt tggaatctga a
//
LOCUS       NM_001436592            1050 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus clathrin, light chain A (Clta), transcript
            variant 1, mRNA.
ACCESSION   NM_001436592 XM_006238106
VERSION     NM_001436592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1050)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1050)
  AUTHORS   Li,H., Alavian,K.N., Lazrove,E., Mehta,N., Jones,A., Zhang,P.,
            Licznerski,P., Graham,M., Uo,T., Guo,J., Rahner,C., Duman,R.S.,
            Morrison,R.S. and Jonas,E.A.
  TITLE     A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics
            during endocytosis
  JOURNAL   Nat Cell Biol 15 (7), 773-785 (2013)
   PUBMED   23792689
REFERENCE   3  (bases 1 to 1050)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1050)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1050)
  AUTHORS   Mettlen,M., Loerke,D., Yarar,D., Danuser,G. and Schmid,S.L.
  TITLE     Cargo- and adaptor-specific mechanisms regulate clathrin-mediated
            endocytosis
  JOURNAL   J Cell Biol 188 (6), 919-933 (2010)
   PUBMED   20231386
  REMARK    GeneRIF: The results underscore the highly dynamic and
            cargo-responsive nature of CCP assembly and suggest that the
            observed heterogeneity is, in part, related to compositional
            differences (e.g., cargo and adaptors) between CCPs.
REFERENCE   6  (bases 1 to 1050)
  AUTHORS   Drake,M.T., Downs,M.A. and Traub,L.M.
  TITLE     Epsin binds to clathrin by associating directly with the
            clathrin-terminal domain. Evidence for cooperative binding through
            two discrete sites
  JOURNAL   J Biol Chem 275 (9), 6479-6489 (2000)
   PUBMED   10692452
REFERENCE   7  (bases 1 to 1050)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   8  (bases 1 to 1050)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   9  (bases 1 to 1050)
  AUTHORS   Kirchhausen,T., Scarmato,P., Harrison,S.C., Monroe,J.J., Chow,E.P.,
            Mattaliano,R.J., Ramachandran,K.L., Smart,J.E., Ahn,A.H. and
            Brosius,J.
  TITLE     Clathrin light chains LCA and LCB are similar, polymorphic, and
            share repeated heptad motifs
  JOURNAL   Science 236 (4799), 320-324 (1987)
   PUBMED   3563513
REFERENCE   10 (bases 1 to 1050)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006238106.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220908.1, BC087577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000005.1  63041212-63041551
            341-378             JAXUCZ010000005.1  63047169-63047206
            379-496             JAXUCZ010000005.1  63048195-63048312
            497-608             JAXUCZ010000005.1  63052248-63052359
            609-1050            JAXUCZ010000005.1  63058782-63059223
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1050
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light chain A"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
     exon            1..340
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..780
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clathrin, light polypeptide (Lca); clathrin, light chain
                     (Lca); lca"
                     /codon_start=1
                     /product="clathrin light chain A isoform 1"
                     /protein_id="NP_001423521.1"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKAS
                     NRAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH
                     "
     misc_feature    187..777
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     misc_feature    187..777
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="Clathrin light chain; Region: Clathrin_lg_ch;
                     pfam01086"
                     /db_xref="CDD:460056"
     exon            341..378
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..608
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1050
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctcctc tccgctcgtc ctccggtagc agccgccagc acagtgtccg ctgctgggcg
       61 gggtgtcggc ggatcggtcg gttggtttcg gcttcggtgt cgctgcgttt gagttgggcc
      121 gtcatggctg agttggatcc atttggcgct cccgccggtg cgcccggtgg ccccgcgctc
      181 gggaacgggg tggcgggcgc cggcgaggaa gacccggccg cggccttctt ggcgcagcag
      241 gagagtgaga ttgcgggcat agagaacgac gaggccttcg ccatcctaga cggcggcgcc
      301 cccgggccgc aggcacacgg cgagccgccg gggggtcctg atgcggttga tggagtgatg
      361 aatggcgaat actaccagga gagcaatggt ccaacagaca gttacgcagc catttcagaa
      421 gtggatcggt tgcagtcaga gcctgaaagt atccgtaagt ggagagaaga gcagacagag
      481 cgcctggaag ccctcgatgc caattctcgg aagcaggaag cagagtggaa agaaaaggcc
      541 gtgaaggagc tggaagagtg gtacgcaagg caggacgagc agctacagaa gacaaaagcc
      601 agcaacaggg cagcagaaga agcctttgta aacgacattg acgagtcatc cccaggcact
      661 gagtgggagc gggtggcccg cctgtgtgac tttaacccca agtccagcaa acaggccaaa
      721 gatgtctctc gcatgcgctc agtcctcatc tccctgaagc aggcgcccct ggtgcattga
      781 agagccaccc tgtggaaaca ctacgtctcc gatcttaatc ctactcagtg aagctgttca
      841 cgcaattgga ttaattatgc cgagttcttt tggaccaaac cttttgtctt tagagttgat
      901 cattgtttgt gattgcatgt ttccttcaac tgtgttctcc ctggcattca gagaagagag
      961 aggaagagga agggagggga gctcccaaca gtagcctcaa cctgtgcttt tgtgcattat
     1021 tctgagaata aatttctgtt tcaaacaata
//
LOCUS       NM_001436989            3055 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus Meis homeobox 1 (Meis1), transcript variant 3,
            mRNA.
ACCESSION   NM_001436989 XM_006251529
VERSION     NM_001436989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Yao,M.Z., Ge,X.Y., Liu,T., Huang,N., Liu,H., Chen,Y., Zhang,Z. and
            Hu,C.P.
  TITLE     MEIS1 regulated proliferation and migration of pulmonary artery
            smooth muscle cells in hypoxia-induced pulmonary hypertension
  JOURNAL   Life Sci 255, 117822 (2020)
   PUBMED   32450174
  REMARK    GeneRIF: MEIS1 regulated the proliferation and migration of
            pulmonary artery smooth muscle cells during hypoxia-induced
            pulmonary hypertension
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Zhang,Y., Si,Y. and Ma,N.
  TITLE     Meis1 promotes poly (rC)-binding protein 2 expression and inhibits
            angiotensin II-induced cardiomyocyte hypertrophy
  JOURNAL   IUBMB Life 68 (1), 13-22 (2016)
   PUBMED   26597775
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Pandey,R., Yang,Y., Jackson,L. and Ahmed,R.P.
  TITLE     MicroRNAs regulating meis1 expression and inducing cardiomyocyte
            proliferation
  JOURNAL   Cardiovasc Regen Med 3 (2016)
   PUBMED   28111633
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Jolma,A., Yin,Y., Nitta,K.R., Dave,K., Popov,A., Taipale,M.,
            Enge,M., Kivioja,T., Morgunova,E. and Taipale,J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Spieler,D., Kaffe,M., Knauf,F., Bessa,J., Tena,J.J., Giesert,F.,
            Schormair,B., Tilch,E., Lee,H., Horsch,M., Czamara,D., Karbalai,N.,
            von Toerne,C., Waldenberger,M., Gieger,C., Lichtner,P.,
            Claussnitzer,M., Naumann,R., Muller-Myhsok,B., Torres,M.,
            Garrett,L., Rozman,J., Klingenspor,M., Gailus-Durner,V., Fuchs,H.,
            Hrabe de Angelis,M., Beckers,J., Holter,S.M., Meitinger,T.,
            Hauck,S.M., Laumen,H., Wurst,W., Casares,F., Gomez-Skarmeta,J.L.
            and Winkelmann,J.
  TITLE     Restless legs syndrome-associated intronic common variant in Meis1
            alters enhancer function in the developing telencephalon
  JOURNAL   Genome Res 24 (4), 592-603 (2014)
   PUBMED   24642863
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006251529.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47505.1,
                                           SRR26643299.55625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               JAXUCZ010000014.1  97495016-97495753   c
            739-965             JAXUCZ010000014.1  97492951-97493177   c
            966-1107            JAXUCZ010000014.1  97491002-97491143   c
            1108-1158           JAXUCZ010000014.1  97490403-97490453   c
            1159-1209           JAXUCZ010000014.1  97489567-97489617   c
            1210-1356           JAXUCZ010000014.1  97487995-97488141   c
            1357-1468           JAXUCZ010000014.1  97465280-97465391   c
            1469-1614           JAXUCZ010000014.1  97417611-97417756   c
            1615-1691           JAXUCZ010000014.1  97381432-97381508   c
            1692-1750           JAXUCZ010000014.1  97361892-97361950   c
            1751-1840           JAXUCZ010000014.1  97360731-97360820   c
            1841-3055           JAXUCZ010000014.1  97356949-97358163   c
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..3055
                     /gene="Meis1"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
     exon            1..738
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    388..390
                     /gene="Meis1"
                     /note="upstream in-frame stop codon"
     CDS             727..2124
                     /gene="Meis1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     homeobox protein Meis1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog"
                     /codon_start=1
                     /product="homeobox protein Meis1 isoform 3"
                     /protein_id="NP_001423918.1"
                     /db_xref="GeneID:686117"
                     /db_xref="RGD:1585482"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRAANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMG
                     QPSYTQAQMPPHPAQLRHGPPMHTYIPGHPHHPAVMMHGGQPHPGMPMSASSPSVLNT
                     GDPTMSGQVMNIHAQ"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    1048..1302
                     /gene="Meis1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(1558..1560,1687..1689,1696..1701,1708..1710)
                     /gene="Meis1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    1597..1713
                     /gene="Meis1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    <1627..2061
                     /gene="Meis1"
                     /note="Cytadhesin P30/P32; Region: Cytadhesin_P30;
                     pfam07271"
                     /db_xref="CDD:429374"
     misc_feature    <1627..2061
                     /gene="Meis1"
                     /note="Cytadhesin P30/P32; Region: Cytadhesin_P30;
                     pfam07271"
                     /db_xref="CDD:429374"
     exon            739..965
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1107
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1158
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1209
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1356
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1468
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1614
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1691
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1750
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1840
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..3055
                     /gene="Meis1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctggtcg gaatccacct ctccgcctgt gcaacacaca ctttacacac gcacggcgac
       61 tgcaagcggg cagcatcgat cgtggctcct ttaagacaaa ctcagacaga cattttttta
      121 accctcctct ctaatctccc ttcagtgcag cagttgcaaa gagggagaga gaaagagaaa
      181 gagagcgaga gaagagagaa actgattggg aattaggact gattcaagga aagcgggcgc
      241 tagggctttg tgcatttgaa tattaacatt tgaggtgttc tgaccagaag aagacagaac
      301 ggatgatcat tcattcacca cgttgacaac ctcgcctgtg attgacagct ggagtggcag
      361 aaagccatga gatttggtag ttggttctga ggggcgctct tttttttctt tttcttttct
      421 tttctttctt tttttttaac tgattttttt gggggggaag agaagatctg cttttttttc
      481 cctcccactg ctgtcttggt ggaaccagag cgcttttatg ctcagcgacg cgggcgcctt
      541 gcttcaggtc cggtagaccg aagatctggg accagtaatt cacactgctg gagacgcaaa
      601 gggatttttt tgttactgtt gtgctttatt tttttttccg agggagtttg catatttgtt
      661 tcttttcaca ctggccttaa agaggatata ttagaagttg aagaaggaag ggaggcagag
      721 aggccgatgg cgcaaaggta cgacgatcta ccccattatg ggggcatgga tggagtaggc
      781 atcccctcca cgatgtatgg ggacccgcat gcagccaggt ctatgcagcc ggtccaccac
      841 ctgaaccacg ggcctcctct gcactctcat cagtacccgc acacagctca taccaacgcc
      901 atggccccca gcatgggctc ctcagtcaat gacgctttaa agagagataa agatgccatt
      961 tatggacacc ccctcttccc tctcttagca ctgatttttg agaaatgtga attagctact
     1021 tgtacccccc gcgagccggg ggtggcgggc ggggacgtct gctcgtcaga gtcattcaat
     1081 gaagatatag cggtgttcgc caaacagatt cgtgcagaaa aacctctatt ctcttctaat
     1141 ccagaactgg ataacttgat gatccaagcc atacaagtat taaggtttca tctgttggaa
     1201 ttagagaagg tacacgaatt atgtgacaat ttctgccacc ggtatattag ctgtttgaaa
     1261 gggaaaatgc ctatcgattt ggtgatagat gatagagaag gcggatcaaa atcagacagt
     1321 gaagatgtaa caagagcagc aaatctaact gaccagccct cttggaatag agaccatgat
     1381 gacacggcat ccactcgttc aggaggaacc ccgggccctt ccagcggtgg ccacacttca
     1441 cacagtgggg ataacagcag tgagcaaggt gatggcttgg acaacagtgt agcttccccc
     1501 agcacaggtg acgatgatga ccctgataag gacaaaaagc gtcacaaaaa gcgtggcatc
     1561 tttcccaaag tagccaccaa tatcatgagg gcgtggctgt tccagcatct aacacaccct
     1621 tacccttctg aagagcagaa aaagcagttg gcacaagata cgggactcac catccttcaa
     1681 gtgaacaatt ggtttattaa tgcgcggaga agaatagtgc agcccatgat agatcagtcc
     1741 aaccgagcag tcagccaagg gacaccttat aaccccgatg gacagccaat gggaggtttt
     1801 gtaatggacg gtcagcagca catgggcatc agagcgccag ggctgcaaag tatgccaggg
     1861 gagtatgtag cccggggtgg tccaatgggt gtgagtatgg gacagccgag ttatacccaa
     1921 gcccagatgc ccccccatcc tgctcagctg cgtcatgggc cccccatgca tacgtacatt
     1981 cctggacatc ctcaccaccc cgcagtgatg atgcatggag gacagcccca ccctggaatg
     2041 ccaatgtcag cgtcaagccc ctcggttctt aatacaggag acccgacaat gagtggacaa
     2101 gtcatgaaca ttcacgctca gtagcttaag ggaatatgca ttgtctgcaa tggtgactga
     2161 tctcgaatca tgtctttttc tgcaatgact atggagttcc attcttgaca tctactttgg
     2221 accaaggagc atccctaatt cttcataggg actcttaaaa atgcaggaaa accaaccgaa
     2281 gtcaatttgg gggacatgca aaaataacta tataagacat taaaagaaca aagagtgaaa
     2341 tattgtaaat gctattatac tgttatccat attacgttgt ttcttataga ttttttaaaa
     2401 aaaatgtgaa atttttccac actatgtgtg ttgtttccat agctcttcac ttcctccaga
     2461 agcctcctta cattaaaaag ccttacagtc atcctgcaag ggacaggaag gtctgatttg
     2521 caggattttt agagcattaa aataactatc aggcagaaga atctttcttc tcgcctagga
     2581 tttcagccat gtgcgcgctc tctctctctc tcctctctct ctcttctcct ctctctccct
     2641 ctctctagcc tggggcttga atttgcatgt ctaattcatt tactcaccat atttgaattg
     2701 gcctgaacag atgtaaatcg ggaaggatgg gaaaaactgc agtcacccaa caatgattaa
     2761 tcagctgttg caggcagtgt cttaaggaga ctggtagaag gagccatgga aacccaaagg
     2821 ccgtgtgttt agaagcctaa ctgtcacgtc aagcgtcatc gtccccatgc gacaacaacc
     2881 atcaccttat acatcacttc ctgttttatg cagctcaaaa aaacatagac tgaagattta
     2941 tttttaatat gttgactttg tttctcagca aagcattggt catgtgtgta tttttccata
     3001 gtcccacctt ggagcattta tgtagacatt gtaaataaat tttgtgcaaa aagga
//
LOCUS       NM_001436657            5623 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 63 (Gpr63), transcript
            variant 1, mRNA.
ACCESSION   NM_001436657 XM_006237949
VERSION     NM_001436657.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5623)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006237949.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12882.1,
                                           SRR26360190.2754819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  43469111-43469298
            189-5623            JAXUCZ010000005.1  43518406-43523840
FEATURES             Location/Qualifiers
     source          1..5623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5623
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
     exon            1..188
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     exon            189..5623
                     /gene="Gpr63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    313..315
                     /gene="Gpr63"
                     /note="upstream in-frame stop codon"
     CDS             337..1614
                     /gene="Gpr63"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 63"
                     /protein_id="NP_001423586.1"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
                     /translation="MVVSGVLTAPAVLTTPHTGTSNMTFVVYENSPMNITAPLPFQHP
                     SPGPLLRYSLETMTSTGFSSLAVNSTVVTPAPAVFKSLNLALQIILSAIMIFILFVSF
                     LGNLVVCLMVYQKAAMRSAINILLASMAFADMLLAVLNMPFALVTILTTRWIFGKFFC
                     RLSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATAFSVAFP
                     LAVGNPDLQIPSRAPQCVFGYTTNSGYQAYVILISLISFFIPFLVILYSFMGILNTLR
                     HNALRIHSYPEGICLSQVSKLGLMSLQRPFQMSIDMSFKTRAFTTILILFAVFIVCWA
                     PFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMM
                     PKSFKFLPRLPGHTRRRIRPSAVYVCGEHRTVL"
     misc_feature    598..1500
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    598..1500
                     /gene="Gpr63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR63; cd15404"
                     /db_xref="CDD:320526"
     misc_feature    601..681
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    601..681
                     /gene="Gpr63"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320526"
     misc_feature    700..777
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    700..777
                     /gene="Gpr63"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320526"
     misc_feature    order(766..768,775..780,814..831,835..840,847..849,
                     973..975,979..993,1069..1071,1078..1086,1090..1098,
                     1102..1107,1333..1335,1342..1347,1351..1356,1363..1365,
                     1399..1404,1408..1416,1423..1425,1432..1437)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    order(766..768,775..780,814..831,835..840,847..849,
                     973..975,979..993,1069..1071,1078..1086,1090..1098,
                     1102..1107,1333..1335,1342..1347,1351..1356,1363..1365,
                     1399..1404,1408..1416,1423..1425,1432..1437)
                     /gene="Gpr63"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320526"
     misc_feature    814..906
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    814..906
                     /gene="Gpr63"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320526"
     misc_feature    931..999
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    931..999
                     /gene="Gpr63"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320526"
     misc_feature    1069..1158
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1069..1158
                     /gene="Gpr63"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320526"
     misc_feature    1273..1365
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1273..1365
                     /gene="Gpr63"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320526"
     misc_feature    1402..1479
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
     misc_feature    1402..1479
                     /gene="Gpr63"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320526"
ORIGIN      
        1 gggagccgcc ggcagccggc aaggcggagg cactgccggg cgatgccccg actctccgcc
       61 gccgcctcct cggcctcctc ctgcgctggg ggctcggagc tgcggagctg cggtgcgatg
      121 tccgcaaagt tccgggaggc agcggtcacc aactcccggc tctatcgccg cggcgccttt
      181 tgtgcgaggc aaacagattc ttgtggaaga tggagctgtg tccattttcc agaatgtgca
      241 tccgagccca tcagtggaac ctgacctgac agcactgtat ggaaatgccc gaagaggacc
      301 cacatttctg cctgaacctg ccaccctcct aaaaacatgg ttgtctccgg agtgttgact
      361 gctccggcag tgttgactac accccatact gggacatcca acatgacatt tgtagtctat
      421 gaaaactccc ccatgaatat tacggcccct ctaccatttc agcatcctag ccctggtcca
      481 ctgcttagat acagtcttga aaccatgact agcactggat ttagttcctt ggcagtgaac
      541 agcacagtgg tgactccagc accagcagtt tttaagagcc taaacttagc tctccagatc
      601 attctctcgg ctatcatgat atttattctg tttgtgtctt ttcttggaaa tttggttgtt
      661 tgcctcatgg tttaccaaaa ggccgccatg cgctctgcaa ttaacatcct tctcgccagc
      721 atggcttttg cagacatgct gcttgctgta ttgaacatgc cctttgccct ggtcactatt
      781 cttactacca gatggatatt tgggaagttc ttctgccggt tgtctgctat gtttttctgg
      841 ttgtttgtga tagagggtgt ggccatcctg ctcattatta gtattgatag gttcctgatt
      901 attgttcaga ggcaagataa gctaaatcca tacagggcta aggttctcat tgcagtctcc
      961 tgggcaactg ctttttctgt agcttttcct ctggctgtgg gaaaccctga tctgcagata
     1021 ccttccagag ccccacagtg tgtatttggg tatacaacca actccggcta tcaggcttat
     1081 gtgattttga tttcactaat ttccttcttt atacctttcc tggtgatact ctattcattt
     1141 atgggcatcc tcaacaccct tcggcacaat gccttgagga ttcatagcta cccggaaggg
     1201 atatgcctca gccaggtcag caaacttggt ctcatgagtc tacagagacc cttccaaatg
     1261 agcatcgaca tgagttttaa aacacgtgcc ttcaccacca ttttgatcct ctttgccgtc
     1321 ttcattgtct gctgggcccc attcaccacc tacagccttg tggctacctt cagtaagcac
     1381 ttttactatc agcacaactt ctttgagatt agcacctggc tactctggct ctgctacctc
     1441 aagtctgcat tgaacccact gatatactac tggaggatta agaagtttca cgatgcctgc
     1501 ttggacatga tgcccaagtc cttcaagttc ttgccacggc tccctggtca cacaaggcga
     1561 cggattcgcc ctagtgcggt ctatgtgtgt ggggagcatc ggacggtgtt gtgaatacct
     1621 gaactcttga gacctatcta atgatgatgg tttttgattg actgggattt ttttcatatg
     1681 gcttctaaag ttttattggt tttaatagta tgtgtgcgtg tgtgggggca tgtaaacgga
     1741 atggtaaata ctttgctcct caaaccaagg taatactgta agaaagtggt cacatatgtt
     1801 tacctctagg ttaagaaaat tttagcgcac gcgtgcgcgc gcgcgtgtgt gtgtgtatgt
     1861 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgttggg ggtggatttt gttagttcag
     1921 ttgactggtt ttatttttgt agcatgaatc aggattgtgc ttcattgaac ttgcagttaa
     1981 cttgaattgt aggtggtttt tatgctgctg aggtaagctt ggttgaggta atcagttcct
     2041 tttcctctcc cacaagccac agcggctgct ccttgccatg tactggagtc aaatccctct
     2101 gcatctcagt tggtagctat ttagttgtat ttaaaaacaa aacccgagga ggttagtgac
     2161 gttttaaagg ttattacact ttactttgga gcactttacg agacaatgta cagactcatt
     2221 cgttgtattt cttagacttg cttttacaca tgacatgctg tgctgtggga gatctgcgct
     2281 tatgatgtct agatagacag cttccattaa aagtgtttta gctgcatgta cagttttaaa
     2341 gggaacataa acacataggg attttcctaa gcacaacggt gagttttcag agcacccagg
     2401 aaacattgag gaggcacagc accatggcaa acttcacgga ggagcagaat gagagggtgg
     2461 gctggtccag cctgtggtca tcctgctgat tcaaacatcg ttaccaactt agagtggggg
     2521 gaccaccact ctgcagtggt gcggtatgca cggaattgcg cagttttttc tcatggcttt
     2581 ttttgtgagg taggtatcat atatttcctc tctaaaggtg aagaaggcca agtttccgag
     2641 ggacaaaaat cctgcccaga gattttggaa tttggcagag ctgggctcca gacatctgag
     2701 atacagacac agatcttccc ctgtgccacc tagacccctc actcaccttc aagctgctat
     2761 actcaagggg aacttcacta cttcacttca catattcttt ttttgttctc tctctctctc
     2821 tctctctctc tctctctctc tttctctttt cctttctgag acatcatttc atgaagctca
     2881 agtaggcctt gaagttgcta tatgtctggg aaagacatgg agtttctaaa agaaacaaac
     2941 agcagaccca gcctttcaaa tggaactcaa aaatatgacg atgaatatga atttgaattt
     3001 ataaggcaag tgacttacag ttactgagtg ctcaatacag ctgaatgggg ggtcttaccc
     3061 cagcagcttt ggaagttcct agcaattcag ctgatcagta gtagggcctt ttgcctcagg
     3121 gcttgcctca gcagagtaag ttgtgaacaa actcaggtaa gtcttccaca gtgaagagac
     3181 gataaaccct ggtctgagct tagattaact gtgatagatc aggctttgga tttctcattc
     3241 tttttcttta gttgtctgcc agtgctggtg catccagaac cttcatcagc ttctcagtta
     3301 cccatggtac agacagaaca gccagcagga gcggaactgc agactgaagg caagaggcct
     3361 tctgactgtc ctgggctaag gcagtatctt aactcagttg gacagcacct tttcggaatt
     3421 ttactgcttt ctgagccact gggaaaaaca agcctgggtt ccttcaatta cagaaaccca
     3481 agttagtttg caagaattgc taaggtttta cccaaccctg aggttttttt attgtctgtc
     3541 cttgttgccc ctcccactct cccatataca agtatagttg gaagagccca gccaacggca
     3601 taactattgt ctggtctcca gtattacttt acatttgctt tgttagctct tttcttaaaa
     3661 tgggtgtctg atgctctctg gcttcgtgat caggaattgg gatgttggaa atttgtttgc
     3721 aacaccaaac acctgggaaa tcctgatttt gatgccattt gaggcaattg caatggtgtt
     3781 gtaattcacc agctgcttaa atagctttag ggactagtga acactatttg ccacattatg
     3841 ttaaggtcac tgcatatgtt agccacctac ctctttgatt tctaatttat atttagcaaa
     3901 ggtaaatatg tctttgtccg ttaggatatt agtagatatt agcagtacat tgaaatgcat
     3961 tttgttttcc attgccaatg taaactgaat tttaaaggcc gatattaata cagatgttga
     4021 aagttcaact ttcaggaaag acagcgttgt gaatatcgat gcatactggt agcttttgag
     4081 tcttcttttg tgactctagt tgaacttggt ttcacatctg tgttcttgct tatgtgcagt
     4141 tgaaggtact gtcttctggt tcataggcag ctacacttgg ggagtgctct gggaagactg
     4201 cagagccaac atgaacagcc atgggggagg ggacattgaa tcgtagctct ctttacactg
     4261 gataatctgg tcagactaca gtttacacat cactttaact attttaatta tatatacatt
     4321 ttgaaagttt taggaaaaaa cactatggtg caacattaag gaatttaggt ataaaattgc
     4381 acattgccta ttattctgtc atttcttgat ggggaaaaca ccactactaa ccactgctga
     4441 ctgacataat cagaaaagtt ttccttctag ctaataggat acatgaaaga gataagaaaa
     4501 tatttgttgt tgttaaaaaa caaaaaagag tgaagagaaa tttcaaatag tttgcagcag
     4561 taatatttaa atttaataca tgtttgaata tcctcaggaa ggctaacaat acaaattcct
     4621 gggcccctgg gtcaatggtt ggatgcagga atgtttattt ctgttgagta ttttgcctga
     4681 ttctggttca gatggtcccc agagcacagt tacaagaaac actcctgtag aaaataagaa
     4741 tatcatttaa acactgtttg cgttatctta aagtagttgt gtgttaggag ccaatggtga
     4801 tacacaatga aaggaagtct ccatgatggg tgccttctgg ttggtttgta tgctggtgca
     4861 gatttggcca gcaccagctt tactttcttt tcactggtga agtctgatga accatgtggt
     4921 ttcacagtag gggtcaacga atgactcact aattgtaagt catgacttcc acaaggctaa
     4981 ttagtatagt attttttcct gcagatgtct ctatagggca tctcttcatt atatgtaatt
     5041 tcctggggag agagggggaa atgtaaaggc tcatctgatt cctaattctc tgctcagacc
     5101 agttgttcag ctgaagcatg aagtgaaata agataatctt taaatcttcg tacttttgtt
     5161 ggtgacagag atatttaatt tctttgatct ttgctttgtt tacatgagaa tgtataggta
     5221 tagatcacaa acatttccac ctgcttgcta ttttattctg tcatgatttt tatttgactt
     5281 caaattacta atagtttcaa atttatttcc ataaccataa ttttgaggaa ctgaacttca
     5341 actccattga agacacaact tttataataa taaaaatatc aaagcacatg tttgttatcg
     5401 caaataaatg ttagtacact tcttagctat ctataggtac ttgtcatttg taattaaaat
     5461 taatttattt taaaatggca cctagccttt aaatgaatga aaagctttta atttgaggtt
     5521 gtaacattta aatatcaaaa gtatgtttat ttgttaatat tcttattaca accaagaaaa
     5581 gagctaccaa taagaaaatg aataaatgtt tactatttct aaa
//
LOCUS       NM_001436992            3751 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus MAF bZIP transcription factor (Maf), transcript
            variant 1, mRNA.
ACCESSION   NM_001436992 XM_039097957
VERSION     NM_001436992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Kim,M., Wende,H., Walcher,J., Kuhnemund,J., Cheret,C., Kempa,S.,
            McShane,E., Selbach,M., Lewin,G.R. and Birchmeier,C.
  TITLE     Maf links Neuregulin1 signaling to cholesterol synthesis in
            myelinating Schwann cells
  JOURNAL   Genes Dev 32 (9-10), 645-657 (2018)
   PUBMED   29748249
  REMARK    GeneRIF: a crucial role of the transcription factor Maf in
            myelination and cholesterol biosynthesis and show that Maf acts
            downstream from Neuregulin1
            Erratum:[Genes Dev. 2018 Aug 1;32(15-16):1101. doi:
            10.1101/gad.318477.118. PMID: 30068704]
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Narumi,Y., Nishina,S., Tokimitsu,M., Aoki,Y., Kosaki,R., Wakui,K.,
            Azuma,N., Murata,T., Takada,F., Fukushima,Y. and Kosho,T.
  TITLE     Identification of a novel missense mutation of MAF in a Japanese
            family with congenital cataract by whole exome sequencing: a
            clinical report and review of literature
  JOURNAL   Am J Med Genet A 164A (5), 1272-1276 (2014)
   PUBMED   24664492
  REMARK    Review article
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Aguayo-Mazzucato,C., Zavacki,A.M., Marinelarena,A.,
            Hollister-Lock,J., El Khattabi,I., Marsili,A., Weir,G.C.,
            Sharma,A., Larsen,P.R. and Bonner-Weir,S.
  TITLE     Thyroid hormone promotes postnatal rat pancreatic beta-cell
            development and glucose-responsive insulin secretion through MAFA
  JOURNAL   Diabetes 62 (5), 1569-1580 (2013)
   PUBMED   23305647
  REMARK    GeneRIF: Data suggest that triiodothyronine (T3) acts as
            physiological regulator of functional maturation of islet
            beta-cells via induction of MAFA/c-Maf; T3 has a direct
            receptor-ligand interaction with MAFA/c-Maf promoter.
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Motomura,Y., Kitamura,H., Hijikata,A., Matsunaga,Y., Matsumoto,K.,
            Inoue,H., Atarashi,K., Hori,S., Watarai,H., Zhu,J., Taniguchi,M.
            and Kubo,M.
  TITLE     The transcription factor E4BP4 regulates the production of IL-10
            and IL-13 in CD4+ T cells
  JOURNAL   Nat Immunol 12 (5), 450-459 (2011)
   PUBMED   21460847
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Ring,B.Z., Cordes,S.P., Overbeek,P.A. and Barsh,G.S.
  TITLE     Regulation of mouse lens fiber cell development and differentiation
            by the Maf gene
  JOURNAL   Development 127 (2), 307-317 (2000)
   PUBMED   10603348
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Kawauchi,S., Takahashi,S., Nakajima,O., Ogino,H., Morita,M.,
            Nishizawa,M., Yasuda,K. and Yamamoto,M.
  TITLE     Regulation of lens fiber cell differentiation by transcription
            factor c-Maf
  JOURNAL   J Biol Chem 274 (27), 19254-19260 (1999)
   PUBMED   10383433
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Kim,J.I., Ho,I.C., Grusby,M.J. and Glimcher,L.H.
  TITLE     The transcription factor c-Maf controls the production of
            interleukin-4 but not other Th2 cytokines
  JOURNAL   Immunity 10 (6), 745-751 (1999)
   PUBMED   10403649
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Matsushima-Hibiya,Y., Nishi,S. and Sakai,M.
  TITLE     Rat maf-related factors: the specificities of DNA binding and
            heterodimer formation
  JOURNAL   Biochem Biophys Res Commun 245 (2), 412-418 (1998)
   PUBMED   9571165
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Sakai,M., Imaki,J., Yoshida,K., Ogata,A., Matsushima-Hibaya,Y.,
            Kuboki,Y., Nishizawa,M. and Nishi,S.
  TITLE     Rat maf related genes: specific expression in chondrocytes, lens
            and spinal cord
  JOURNAL   Oncogene 14 (6), 745-750 (1997)
   PUBMED   9038383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Mar 25, 2025 this sequence version replaced XM_039097957.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53119.1,
                                           SRR26643298.76609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2062              JAXUCZ010000019.1  60620074-60622135   c
            2063-2123           JAXUCZ010000019.1  60607288-60607348   c
            2124-3751           JAXUCZ010000019.1  60597423-60599050   c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3751
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="MAF bZIP transcription factor"
                     /db_xref="GeneID:54267"
                     /db_xref="RGD:3034"
     exon            1..2062
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    852..854
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="upstream in-frame stop codon"
     CDS             957..2096
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor Maf; C-Maf; proto-oncogene c-maf;
                     transcription factor Maf-2; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog; bZip transcription factor
                     c-maf"
                     /codon_start=1
                     /product="transcription factor Maf isoform 1"
                     /protein_id="NP_001423921.1"
                     /db_xref="GeneID:54267"
                     /db_xref="RGD:3034"
                     /translation="MASELAMNNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIIS
                     QCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLN
                     PEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPA
                     AAVVSAVIAAAAAQSGGAPHYHHHHHHATGHHHHPTAGAPGAAGSASASASGAGGAGG
                     GGPASAGGGGGGGGGGTAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRG
                     VSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLV
                     RERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFMYPRDSSTSVM"
     mat_peptide     957..2063
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /product="Transcription factor Maf. /id=PRO_0000076493"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1)"
     misc_feature    1125..1202
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1212..1313
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Maf N-terminal region; Region: Maf_N; pfam08383"
                     /db_xref="CDD:462456"
     misc_feature    1212..1313
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Maf N-terminal region; Region: Maf_N; pfam08383"
                     /db_xref="CDD:462456"
     misc_feature    1332..2063
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Represses ARE-mediated transcription.
                     /evidence=ECO:0000250"
     misc_feature    1479..1685
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1791..1997
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; Region:
                     bZIP_Maf_large; cd14718"
                     /db_xref="CDD:269866"
     misc_feature    1791..1997
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; Region:
                     bZIP_Maf_large; cd14718"
                     /db_xref="CDD:269866"
     misc_feature    1791..1997
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269866"
     misc_feature    1791..1997
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269866"
     misc_feature    1806..1883
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     misc_feature    order(1812..1814,1821..1829,1833..1841,1845..1853,
                     1857..1862,1866..1871)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     misc_feature    order(1812..1814,1821..1829,1833..1841,1845..1853,
                     1857..1862,1866..1871)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     misc_feature    order(1869..1871,1890..1892,1899..1904,1911..1916,
                     1920..1925,1932..1937,1941..1946,1953..1955,1962..1967,
                     1974..1979,1983..1988)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269866"
     misc_feature    order(1869..1871,1890..1892,1899..1904,1911..1916,
                     1920..1925,1932..1937,1941..1946,1953..1955,1962..1967,
                     1974..1979,1983..1988)
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269866"
     misc_feature    1890..1955
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /note="propagated from UniProtKB/Swiss-Prot (P54844.1);
                     Region: Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     exon            2063..2123
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..3751
                     /gene="Maf"
                     /gene_synonym="cMaf; Maf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgctggat cagaggcttt aaaatctttt ttcatctcgg agctgtagct cgagctgctt
       61 gtccgctcgg cctctccccc cacccttttg ctctcggcct tgccttggtc caggactttg
      121 ccattttgct ttaaagcaaa aaaagaaaga aagaaagaaa agaaaagaaa aaccaaaacc
      181 aaaagaaaaa aaaaagggca agaaagaact aaactccccc ctcccttgcc tccagccggc
      241 ctgcacctcg gtcttgcact ttgcacggag ggagagggtg aggagagaaa gagagagcgc
      301 gcgcgcacgc gagggatccg gagagagaaa agaaaataat aatagtaacc ataagagcca
      361 ggcagaagag gagagaagcg tgaagtgtta accaccccgg tgtggaggcc cgcgcctccg
      421 ggacagccac ccgccgcgcc acacaacccc ggagcagccg ccgcgcgcgc cccgcctgca
      481 gccccgaccg gcttaggcga gccctcctta tgcaaagcgc gcagcggagc ggcgagccgg
      541 ggacgccgcg caccgggccg ggctcctccg gcatcctctc tgccgctgtc atcaccaccg
      601 ccaccgccag ccgcggagga ccttcccgag cctgaagcgc ccgggatcgg agctcagaga
      661 ggcgagcagg cgaggagggg gcccggggcg agcgggagag agagagagag agcaagagag
      721 aaagagagag agcacattgg cgtgagcagg ggggagggag ggcgggcgcg gggggctgcg
      781 ggcagggcgg ggggtgtgtg cacgctcgag ctttcgggcc acagccaccg ccgcgcgagc
      841 tagaagcgcc ctagcccggc aagctggctc acccgctggc cacccagcac agcccgctgg
      901 cccctctcct gcagcccatc tggcggagcg gcggcggcgg tggcggaggc aggaggatgg
      961 cttcagaact ggcaatgaac aattccgacc tgcccaccag tcccctggcc atggaatatg
     1021 ttaatgactt cgatctgatg aagtttgaag tgaaaaagga accggtggag accgaccgca
     1081 tcatcagcca gtgcggccgt ctcatcgccg ggggctcgct gtcctccacc cccatgagca
     1141 cgccctgcag ctcggtgccc ccgtccccca gcttctcggc gcccagcccg ggctcgggca
     1201 gcgaacagaa ggcgcacctg gaagactact actggatgac cggctacccg cagcagctca
     1261 acccggaggc gctgggcttc agcccggagg acgcagtcga ggcgctcatc agcaatagcc
     1321 accagctcca gggtggcttc gatggctatg cgcggggagc gcagcagctg gccgcggcag
     1381 cgggggccgg cgccggcgcc tccctgggcg gcagcggcga ggagatgggc cccgccgccg
     1441 ccgtggtgtc cgccgtgatc gccgcggccg ccgcgcagag cggcggggca cctcactacc
     1501 atcaccacca ccaccacgcc acggggcacc accaccaccc gacggccggc gccccgggag
     1561 ccgcgggtag cgcgtccgcc tctgcgagcg gcgcgggtgg cgcgggcggc ggtggcccgg
     1621 ccagcgccgg gggcggcggc ggcggcggcg gcgggggcac ggcgggggcg gggggcgccc
     1681 tgcacccgca ccatgccgcg ggaggcctgc acttcgacga ccgcttctcg gacgagcagt
     1741 tggtgaccat gtcggtgcgt gagctgaacc ggcagctgcg cggggtcagc aaggaggagg
     1801 tgatccgact gaagcagaag aggcggaccc tgaaaaaccg cggctatgcc cagtcctgcc
     1861 gcttcaagag ggtgcagcag agacacgtcc tggagtcgga gaagaaccag ctgctgcagc
     1921 aggtcgacca cctcaagcag gagatctcca ggctggtgcg cgaaagggac gcctacaagg
     1981 agaaatacga gaagttggtg agcagcgggt tccgagaaaa cggctcgagc agcgacaacc
     2041 cttcctctcc cgaatttttc atgtacccaa gggactcttc tacatctgtg atgtgagaaa
     2101 agcagttgcc cgaagctgaa cagagaagag agtccgctta ctcgctcctt gttgcgtgca
     2161 cacaagcaag gttttatttt ctgaaattgg aaactatttt ttacaaaggt accttggaca
     2221 aacttgcacc caggatgtca gtgcatgtga ccaacatctt ggatactgga gcacctatga
     2281 gtaggggttt ttctgaagca cacccttgtc aaagaagaag aaactgtaca gaatggggcc
     2341 ctcaaagagt accctggcat gcgtggagac ggaccgtcat gctctaggac attgttccct
     2401 cgagcagaca ctgtaggata caacttaaga catttctctt tgaaccgctt tagctacaga
     2461 gattatgaga ctttttaaaa atatatactt caaggacgat tggtatttaa cgtttgttat
     2521 ggccacacgg aggccatacc gtgttggttg gagttagaat tgacatccat gcactcggac
     2581 ctcccactca gacatttaca gagttgatgg gtgtgatggg aagttacaga ggagcaagga
     2641 gtctcccagg agacagaacc tgtcatcttc agtccttgaa acaagtctag gggtagatac
     2701 tttaatccac tttaacaatg tggagggtac tgggcacaaa ggaatttagg tgccctgtaa
     2761 cccttcacta ccatcttgct tagctaccta ccacgccact tcctccctgt cagtcagtct
     2821 gtctgcagcc ttcctgggtc acacacttta gcttttagcc tcaatttgta ctgtaagtgt
     2881 ccaagtgccc tccccttggc ctcctttcct gagcagggat gagtgtggct cagaagaaag
     2941 gacacataat gtgattagta tctggaggtc tagagccatg gcttctcgtg gtcttgaccc
     3001 cccaaggacc cctgtgagtc tctgaacaaa cgatcctgta ctgttgattt cggaaggcga
     3061 cgggaaagga gttccagtcg aaagataatg attgccatcc ccagccgcag tttaacagta
     3121 attgatgaca cttctcctca aaaactccat aatgtgtgaa gagtcactca gcacgttgct
     3181 ggatagtgga gatccacatc gctgttggta aatctctcca acggaagccc tgttgaataa
     3241 aagttgtccg cgaaatcagc accgctacta caaaaaaata caatttccac atctcgagga
     3301 tgggaactgt ccctccaagg ggaacagaaa ggattaaata tggtaatata tgtaaagcac
     3361 ttggattaaa tatgttaata tatgtaaaac acctgccctg ggtaaacacc ctccctgcca
     3421 tgttcagcca tggacagtgt tacaggggat aaaattctga ccttgacact taacaagcct
     3481 tggtttacat tagaataacg ttgtgattac agtattgagc ttcccccacc ccaccacacc
     3541 ccacccccag cccaccgttt taaaataaac gttttcaaaa atcagaaaac cgaggttggt
     3601 aacgcttatg gccattcctt tatttaaaaa aaaaaaaatc tcatcacccc taaaaataaa
     3661 ataaaataaa atcatcgtac tttgaggagc tctctgctca aatagtttag ggaaacgtgt
     3721 gtattaaatt aaacatttaa tattgctgtc a
//
LOCUS       NM_001024965            1474 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus trafficking protein particle complex subunit 2
            (Trappc2), mRNA.
ACCESSION   NM_001024965 XM_576952
VERSION     NM_001024965.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Milev,M.P., Hasaj,B., Saint-Dic,D., Snounou,S., Zhao,Q. and
            Sacher,M.
  TITLE     TRAMM/TrappC12 plays a role in chromosome congression, kinetochore
            stability, and CENP-E recruitment
  JOURNAL   J Cell Biol 209 (2), 221-234 (2015)
   PUBMED   25918224
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Menon,S., Cai,H., Lu,H., Dong,G., Cai,Y., Reinisch,K. and
            Ferro-Novick,S.
  TITLE     mBET3 is required for the organization of the TRAPP complexes
  JOURNAL   Biochem Biophys Res Commun 350 (3), 669-677 (2006)
   PUBMED   17027922
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Fan,L., Yu,W. and Zhu,X.
  TITLE     Interaction of Sedlin with chloride intracellular channel proteins
  JOURNAL   FEBS Lett 540 (1-3), 77-80 (2003)
   PUBMED   12681486
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Ghosh,A.K., Majumder,M., Steele,R., White,R.A. and Ray,R.B.
  TITLE     A novel 16-kilodalton cellular protein physically interacts with
            and antagonizes the functional activity of c-myc promoter-binding
            protein 1
  JOURNAL   Mol Cell Biol 21 (2), 655-662 (2001)
   PUBMED   11134351
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Gedeon,A.K., Colley,A., Jamieson,R., Thompson,E.M., Rogers,J.,
            Sillence,D., Tiller,G.E., Mulley,J.C. and Gecz,J.
  TITLE     Identification of the gene (SEDL) causing X-linked
            spondyloepiphyseal dysplasia tarda
  JOURNAL   Nat Genet 22 (4), 400-404 (1999)
   PUBMED   10431248
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091429.1.
            
            On or before Apr 26, 2006 this sequence version replaced
            XM_576952.1, XM_213295.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN802820.1, CV110307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..1474
                     /gene="Trappc2"
                     /note="trafficking protein particle complex subunit 2"
                     /db_xref="GeneID:501550"
                     /db_xref="RGD:1306925"
     exon            1..14
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
     exon            15..85
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Trappc2"
                     /note="upstream in-frame stop codon"
     exon            86..197
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..527
                     /gene="Trappc2"
                     /note="sedlin; trafficking protein particle complex
                     protein 2"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 2"
                     /protein_id="NP_001020136.1"
                     /db_xref="GeneID:501550"
                     /db_xref="RGD:1306925"
                     /translation="MSGSFYFVIVGHHDNPVFEMEFLPPGKAESKDDHRHLNQFIAHA
                     ALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDV
                     YDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS"
     misc_feature    114..518
                     /gene="Trappc2"
                     /note="Trafficking protein particle complex subunit 2;
                     Region: TRAPPC2_sedlin; cd14825"
                     /db_xref="CDD:341429"
     misc_feature    114..518
                     /gene="Trappc2"
                     /note="Trafficking protein particle complex subunit 2;
                     Region: TRAPPC2_sedlin; cd14825"
                     /db_xref="CDD:341429"
     misc_feature    order(261..266,330..338,342..344,411..413,423..425,
                     435..437)
                     /gene="Trappc2"
                     /note="TRAPPC5 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:341429"
     misc_feature    order(261..266,330..338,342..344,411..413,423..425,
                     435..437)
                     /gene="Trappc2"
                     /note="TRAPPC5 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:341429"
     misc_feature    order(426..428,435..446)
                     /gene="Trappc2"
                     /note="TRAPPC3 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:341429"
     misc_feature    order(426..428,435..446)
                     /gene="Trappc2"
                     /note="TRAPPC3 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:341429"
     exon            198..342
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..428
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1450
                     /gene="Trappc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaggttcg cgaggaaaca cattccagat ttctttggat gtcattgatt ttcctgtgaa
       61 tcagcagaag acctagaggg gcttggagct acatattgaa gacaatgtct ggaagcttct
      121 actttgtaat tgttggccac catgataatc cagtttttga aatggaattt ttgccacctg
      181 ggaaagcaga atccaaagat gatcaccgtc atctgaacca gtttatagct catgctgctc
      241 ttgaccttgt ggatgaaaat atgtggcttt ctaacaacat gtacttaaaa actgtggaca
      301 aatttaatga gtggtttgtg tcagcatttg tcactgcagg gcatatgaga tttattatgc
      361 ttcatgatgt gaggcaagaa gatggaataa agaacttctt tactgatgtc tatgatttgt
      421 atataaagtt tgcaatgaat ccattttatg aacccaattc tcctattcga tcaagtgcat
      481 ttgacagaaa agttcagttt cttgggaaga aacacctttt aagctaaatg gagaaactct
      541 gcaataagct gtatcatcgt ggggtgtgct caggagtgtg tgttctgtaa gtaatttgaa
      601 attgcctgga aaacgttccc ttaaaattgt acattgtttt catattgact gtcattagca
      661 ttgatatttg cttgtggaca atgttattta caaacagttc tgtaccagta attttgaaca
      721 cttttattta tttaaaagct tgagaagact cttgcctttc ctaagataat ttgatattaa
      781 tttattaatt caaaagcata ttatgtcata gttaatattt gttagaatga tttaagactg
      841 aaaagttctg gagatgaatg aaattgagtt atttacacat ttagagatgt tcttttaaaa
      901 tgcatagtac actgcagtac caagaagctg aagcagaaag cccatgccag tgctacccgc
      961 ttgcctccct ccaccagagg ctgtgaataa tcacccggct gtaactctaa acccctagac
     1021 ctatatatgc tggaccagtt ccaggccatg gcaaagtatg ttgcctctgt caccttatat
     1081 tctagtgttt cctttctctt agtaaactaa aggtttactt tatttaaact tgttaatatc
     1141 tgtatttgaa aaaatgttat aatactgatt gggtattgct aataaaagct tgggttatac
     1201 tgacacttgc acttaactaa cctttttgct atctatatac aggatgcgag gtggcagatg
     1261 tggcctcttg tcttagatat ggtggtgtta cagtagtaga tatgcatgaa aaagcaaacc
     1321 agattttcat gtgtacactg gaaaaatttc attctaacat ttgagtaagc acttctaaac
     1381 tttcttgtat tctttggtga cattgttact atcacttttt tttatttctt aaataaagat
     1441 ttatatccaa aaaaaaaaaa aaaaaaaaaa aaaa
//
LOCUS       NM_001170551           13943 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus WD repeat and FYVE domain containing 3 (Wdfy3),
            mRNA.
ACCESSION   NM_001170551 XM_001060345 XM_001060403 XM_223196
VERSION     NM_001170551.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 13943)
  AUTHORS   Filimonenko,M., Isakson,P., Finley,K.D., Anderson,M., Jeong,H.,
            Melia,T.J., Bartlett,B.J., Myers,K.M., Birkeland,H.C., Lamark,T.,
            Krainc,D., Brech,A., Stenmark,H., Simonsen,A. and Yamamoto,A.
  TITLE     The selective macroautophagic degradation of aggregated proteins
            requires the PI3P-binding protein Alfy
  JOURNAL   Mol Cell 38 (2), 265-279 (2010)
   PUBMED   20417604
REFERENCE   2  (bases 1 to 13943)
  AUTHORS   Clausen,T.H., Lamark,T., Isakson,P., Finley,K., Larsen,K.B.,
            Brech,A., Overvatn,A., Stenmark,H., Bjorkoy,G., Simonsen,A. and
            Johansen,T.
  TITLE     p62/SQSTM1 and ALFY interact to facilitate the formation of p62
            bodies/ALIS and their degradation by autophagy
  JOURNAL   Autophagy 6 (3), 330-344 (2010)
   PUBMED   20168092
REFERENCE   3  (bases 1 to 13943)
  AUTHORS   Simonsen,A., Birkeland,H.C., Gillooly,D.J., Mizushima,N., Kuma,A.,
            Yoshimori,T., Slagsvold,T., Brech,A. and Stenmark,H.
  TITLE     Alfy, a novel FYVE-domain-containing protein associated with
            protein granules and autophagic membranes
  JOURNAL   J Cell Sci 117 (Pt 18), 4239-4251 (2004)
   PUBMED   15292400
REFERENCE   4  (bases 1 to 13943)
  AUTHORS   Chen,G.Y., Muramatsu,H., Ichihara-Tanaka,K. and Muramatsu,T.
  TITLE     Expression profile of mouse BWF1, a protein with a BEACH domain,
            WD40 domain and FYVE domain
  JOURNAL   Cell Struct Funct 29 (2), 35-42 (2004)
   PUBMED   15342963
REFERENCE   5  (bases 1 to 13943)
  AUTHORS   Uehara,K. and Muramatsu,T.
  TITLE     Molecular cloning and characterization of
            beta-1,4-galactosyltransferase expressed in mouse testis
  JOURNAL   Eur J Biochem 244 (3), 706-712 (1997)
   PUBMED   9108238
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 29, 2024 this sequence version replaced NM_001170551.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000014.1  7911151-7911239
            90-188              JAXUCZ010000014.1  7943320-7943418
            189-399             JAXUCZ010000014.1  7967944-7968154
            400-523             JAXUCZ010000014.1  7977367-7977490
            524-633             JAXUCZ010000014.1  7984830-7984939
            634-795             JAXUCZ010000014.1  7988553-7988714
            796-988             JAXUCZ010000014.1  7994821-7995013
            989-1175            JAXUCZ010000014.1  7996299-7996485
            1176-1342           JAXUCZ010000014.1  7999126-7999292
            1343-1810           JAXUCZ010000014.1  8002882-8003349
            1811-1912           JAXUCZ010000014.1  8004143-8004244
            1913-2106           JAXUCZ010000014.1  8006943-8007136
            2107-2564           JAXUCZ010000014.1  8012334-8012791
            2565-2648           JAXUCZ010000014.1  8014015-8014098
            2649-2826           JAXUCZ010000014.1  8019206-8019383
            2827-3041           JAXUCZ010000014.1  8020117-8020331
            3042-3154           JAXUCZ010000014.1  8023560-8023672
            3155-3386           JAXUCZ010000014.1  8025923-8026154
            3387-3487           JAXUCZ010000014.1  8027149-8027249
            3488-3706           JAXUCZ010000014.1  8027372-8027590
            3707-3888           JAXUCZ010000014.1  8028507-8028688
            3889-4120           JAXUCZ010000014.1  8030620-8030851
            4121-4281           JAXUCZ010000014.1  8032120-8032280
            4282-4393           JAXUCZ010000014.1  8034210-8034321
            4394-4584           JAXUCZ010000014.1  8037612-8037802
            4585-4737           JAXUCZ010000014.1  8038779-8038931
            4738-4811           JAXUCZ010000014.1  8042049-8042122
            4812-4973           JAXUCZ010000014.1  8042206-8042367
            4974-5068           JAXUCZ010000014.1  8043302-8043396
            5069-5189           JAXUCZ010000014.1  8047967-8048087
            5190-5407           JAXUCZ010000014.1  8048421-8048638
            5408-5643           JAXUCZ010000014.1  8050245-8050480
            5644-5778           JAXUCZ010000014.1  8051932-8052066
            5779-5958           JAXUCZ010000014.1  8053453-8053632
            5959-6192           JAXUCZ010000014.1  8054671-8054904
            6193-6292           JAXUCZ010000014.1  8060349-8060448
            6293-6453           JAXUCZ010000014.1  8061847-8062007
            6454-6683           JAXUCZ010000014.1  8063358-8063587
            6684-6793           JAXUCZ010000014.1  8064827-8064936
            6794-6976           JAXUCZ010000014.1  8066562-8066744
            6977-7134           JAXUCZ010000014.1  8067734-8067891
            7135-7212           JAXUCZ010000014.1  8068862-8068939
            7213-7440           JAXUCZ010000014.1  8069201-8069428
            7441-7609           JAXUCZ010000014.1  8075876-8076044
            7610-7773           JAXUCZ010000014.1  8078259-8078422
            7774-7922           JAXUCZ010000014.1  8082272-8082420
            7923-8043           JAXUCZ010000014.1  8084541-8084661
            8044-8129           JAXUCZ010000014.1  8085123-8085208
            8130-8210           JAXUCZ010000014.1  8087030-8087110
            8211-8265           JAXUCZ010000014.1  8088842-8088896
            8266-8385           JAXUCZ010000014.1  8089091-8089210
            8386-8503           JAXUCZ010000014.1  8091293-8091410
            8504-8610           JAXUCZ010000014.1  8092442-8092548
            8611-8764           JAXUCZ010000014.1  8093848-8094001
            8765-8856           JAXUCZ010000014.1  8095777-8095868
            8857-9069           JAXUCZ010000014.1  8096066-8096278
            9070-9217           JAXUCZ010000014.1  8099179-8099326
            9218-9372           JAXUCZ010000014.1  8099465-8099619
            9373-9531           JAXUCZ010000014.1  8100609-8100767
            9532-9711           JAXUCZ010000014.1  8102576-8102755
            9712-9894           JAXUCZ010000014.1  8103586-8103768
            9895-9991           JAXUCZ010000014.1  8104920-8105016
            9992-10309          JAXUCZ010000014.1  8107414-8107731
            10310-10421         JAXUCZ010000014.1  8107963-8108074
            10422-10619         JAXUCZ010000014.1  8108424-8108621
            10620-13943         JAXUCZ010000014.1  8111679-8115002
FEATURES             Location/Qualifiers
     source          1..13943
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..13943
                     /gene="Wdfy3"
                     /note="WD repeat and FYVE domain containing 3"
                     /db_xref="GeneID:305164"
                     /db_xref="RGD:1307097"
     exon            1..89
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            90..188
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    184..186
                     /gene="Wdfy3"
                     /note="upstream in-frame stop codon"
     exon            189..399
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..10743
                     /gene="Wdfy3"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 3"
                     /protein_id="NP_001164022.3"
                     /db_xref="GeneID:305164"
                     /db_xref="RGD:1307097"
                     /translation="MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQ
                     KEQEEKLYMMLPVFNRVFGNAPPSTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTE
                     AASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKAVDCMTTMSVPSTLVKCLYLF
                     FDLPHVPEAGGGAQSELPLAERRGLLQKAFVQILVKLCSFVSPAEELAQKDDLQLLFS
                     AITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSP
                     LEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAECRDALKD
                     LVSLVTSLTTYGVSELKPAGVTTGAPFLLPGFSVPQPAGKGHSVRNIQAFAVLQNAFL
                     KAKTNFLAQIILDAITDIYMADSANYFILESQHTLSQFAEKISKLPEVQSKYFEMLEF
                     VVFSLNYIPCKELISVSILLKSSSSHHCSIVAMKTLLKFTRHDYIFKDVFREVGLLEV
                     MVNLLHKYAALLKDPAQALGEQGDSRNNSSVEDQKHLALLVMEALTVLLQGSNTNAGI
                     FREFGGARCAHNIVKYPQCRQHALMTIQQLVLSPNGEDDMGTLLGLMHSAPPTELQLK
                     TDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSSPPKNGWEKVNQNQVF
                     ELLHTVFCTLTAALRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAVNVFPSN
                     TSPFQRLLEEGAVPMDSVSPTLRHCSKLFIYLYKVATDSFDSRTEQIPPCLTSESSLP
                     SPWGTPALSRKRHAFHCVSTPPVYPAKSVTDLKLQVTSSPLPSSEAVIIHPGAMLAML
                     DLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCGAALAD
                     EDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLS
                     FEPDMRSSVVTSLEGLGSDSVFSSHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTT
                     PHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNAVTTGLTDGAVVSGIG
                     SGERFFPPPSGLSYSCWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAK
                     DRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELVVEGQWHHLALLMSRGM
                     LKNSTAALYIDGQLVSTVKLHYVHSTPGGSGSANPPVLSTVYAYIGTPPAQRQMASLV
                     WRLGPTHFLEEVLPPSSVTAIYELGPDYVGSFQAVLVPCKDSKSEGIIPSPVSLVAEE
                     KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLVHNAAGHLNG
                     PARTIGAALIGYLGVRTFVPKPVATTLQYIGGAAAILGLVAMASDVEGLYAAVKALVC
                     VVKSNPLASKEMERIKGYQLLAMLLKKRRSLLNSHILHLTFSLVGTVDSGHETSIIPN
                     STAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLT
                     LRDMSLSQPTIAAMSNVLSHLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEIIN
                     EGKPDSGAEEEFGGLVSANLILLRNRLLDILLKLVYTSKEKTNINLQACEELVRTLGF
                     DWIMMFMEEHLHPTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIG
                     TVLGFNVGRSAGGRSTVREINRDACHFPGFLVLQSFLPKHTNVPALYFLLMALFLQQP
                     VSELPENLQVSVPVTNSRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTESAFL
                     LLGMLRSMLNSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWLSPDFLCALAA
                     TVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPA
                     KKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTHILDSVMDH
                     LLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQ
                     LIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILG
                     PGNHDQEFISCLAHCLINLHAGSSVEGFGLEAEARMTTWHIMIPSDIEPDGGYSQDIS
                     EGRQLLIKAVNRVWTELIHSKKQVLEEVFKVSLPVNDRGHVDIAVARPLIEEAGLKGW
                     QNHLAHEKKCISRGEALVPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSPSPQE
                     ISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGS
                     HLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQEASVGKPARYRRAISYDSKE
                     YYLRLASGNPTIVQDAIVESSEGEATQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGG
                     DEETQEQLQDQIAESGSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLL
                     LFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYED
                     IKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSG
                     QRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVF
                     PWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYG
                     THYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKE
                     LIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYV
                     SAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNF
                     GQIPKQLFKKPHPPKRVRSRLNGENAGLSVPPGATSDKIFFHHLDNLRPSLTPVKELK
                     EPVGQIVCTDKGILAVEQNKVLIPPAWNKTFAWGYADLSCRLGTYESDKAVAVYECLS
                     EWGQILCAVCPSPKLVITGGTSTVVCVWEMGTSKEKAKPLTLKQALLGHTDTVTCATA
                     SIAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYVH
                     VWSINGNPIVSVNTFTGRSQQIVCCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQV
                     PETPAPEPVEDLEMQEGCPEAQIGQQAQDEDSSDSEAEEPSVSQDPKDTPSQPSSTSH
                     RPRAASCRATATWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQARAHPQGSHSHP
                     NPTEARSYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNTHPAEVTALGVSKDHSRILV
                     GDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQ
                     KCSRFQSEIKRLKISSPVRVCQNCYYSLQHERGADDGPRNC"
     misc_feature    7768..8139
                     /gene="Wdfy3"
                     /note="Pleckstrin homology domain in BEACH domain
                     containing proteins; Region: PH_BEACH; cd01201"
                     /db_xref="CDD:275391"
     misc_feature    7768..8139
                     /gene="Wdfy3"
                     /note="Pleckstrin homology domain in BEACH domain
                     containing proteins; Region: PH_BEACH; cd01201"
                     /db_xref="CDD:275391"
     misc_feature    8254..9096
                     /gene="Wdfy3"
                     /note="Beige/BEACH domain; Region: Beach; pfam02138"
                     /db_xref="CDD:460459"
     misc_feature    8254..9096
                     /gene="Wdfy3"
                     /note="Beige/BEACH domain; Region: Beach; pfam02138"
                     /db_xref="CDD:460459"
     misc_feature    <9301..9909
                     /gene="Wdfy3"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cl29593"
                     /db_xref="CDD:475233"
     misc_feature    <9301..9909
                     /gene="Wdfy3"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cl29593"
                     /db_xref="CDD:475233"
     misc_feature    9301..9384
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9301..9384
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9418..9543
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9418..9543
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9559..9669
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9559..9669
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9682..9795
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9682..9795
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9814..9921
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    9814..9921
                     /gene="Wdfy3"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    10507..10701
                     /gene="Wdfy3"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein 3 (WDFY3) and similar proteins;
                     Region: FYVE_WDFY3; cd15719"
                     /db_xref="CDD:277259"
     misc_feature    10507..10701
                     /gene="Wdfy3"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein 3 (WDFY3) and similar proteins;
                     Region: FYVE_WDFY3; cd15719"
                     /db_xref="CDD:277259"
     misc_feature    order(10513..10515,10522..10524,10576..10593,10597..10602,
                     10672..10680)
                     /gene="Wdfy3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277259"
     misc_feature    order(10513..10515,10522..10524,10576..10593,10597..10602,
                     10672..10680)
                     /gene="Wdfy3"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]; other site"
                     /db_xref="CDD:277259"
     exon            400..523
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..633
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..795
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..988
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1175
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1342
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1810
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1912
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2106
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2564
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2648
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2826
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3041
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3154
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3386
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3487
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3706
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3888
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4120
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4281
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4393
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4584
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4737
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4811
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4973
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5068
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5189
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5190..5407
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5643
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5644..5778
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5779..5958
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            5959..6192
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6193..6292
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6293..6453
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6454..6683
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6684..6793
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6794..6976
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            6977..7134
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7135..7212
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7213..7440
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7441..7609
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7610..7773
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7774..7922
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            7923..8043
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8044..8129
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8130..8210
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8211..8265
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8266..8385
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8386..8503
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8504..8610
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8611..8764
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8765..8856
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            8857..9069
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9070..9217
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9218..9372
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9373..9531
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9532..9711
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9712..9894
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9895..9991
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            9992..10309
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            10310..10421
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            10422..10619
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
     exon            10620..13943
                     /gene="Wdfy3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgacact tcccgacatc tgcttcagga agaacgtgcc tgtcactcct gtcttcgcag
       61 attcatgcca gcccagcaca cagcgtcagt tggaaccccg atttcaagtc ctgagtgaag
      121 tgccatctgt ggatgggacc cactgtgctc acacactcag aaggagctgt ccaaggaatg
      181 ccctaaagaa acagaagtgc acttcgccca ccagccaaga tgaacatggt gaagaggatc
      241 atggggcggc ctcggcagga ggagtgcagc cctcaggaca acgccctggg cctgatgcac
      301 ctccgacggc tcttcaccga gctgtgccac cctccgaggc acatgaccca gaaggagcag
      361 gaggagaagc tgtacatgat gctgccagtg ttcaacaggg tttttggaaa tgccccgcca
      421 agtacaatga cagaaaagtt ttctgacctt ctgcagttca ccacgcaagt ctcccgacta
      481 atggtgacgg agattcggag gagagcgtca aacaaatcca cagaggctgc aagccgggcc
      541 atagtccagt tcctggagat caatcagagc gaagaagcca gtagaggctg gatgctccta
      601 acaacaatta acctgctggc atcctctggt cagaaagccg tggactgcat gacaacgatg
      661 tcagtgccat ccaccctggt taagtgtctg tatctgttct ttgaccttcc ccatgtgcct
      721 gaggcaggtg ggggcgccca gagcgagcta cctctagcag agcgccgcgg actgctccag
      781 aaagcctttg tgcagatctt agtaaaactc tgcagtttcg tttctccggc ggaggagctg
      841 gcccagaagg acgacctgca gcttttattc agtgcaataa cctcttggtg ccccccctat
      901 aacctgccgt ggaggaagag cgcgggggag gtcctcatga ccatctcgcg ccatgggctg
      961 agcgtgaacg tggtaaagta catacatgaa aaagagtgtt tgtctacgtg tgttcagaat
     1021 atgcagcaat cagacgacct gtctcccctc gaaattgttg aaatgtttgc gggactctct
     1081 tgtttcctca aagactccag tgatgtttcc cagacacttc tggatgattt tcggatatgg
     1141 caaggatata attttctttg tgacctcttg ctcagactgg aacaagcgaa agaggcagag
     1201 tgcagagatg ccttgaagga tctggtgagc ctggtgacct ctctgaccac ctatggggtc
     1261 agtgagctga agccagctgg tgtcaccaca ggggccccct tcctgttgcc tggattttca
     1321 gtacctcagc cagcgggcaa aggtcacagt gtgagaaaca tccaggcctt cgccgttctt
     1381 cagaacgcat ttttaaaagc aaaaaccaac ttccttgccc agatcatcct ggacgccatc
     1441 acggacatct acatggcgga cagtgctaac tacttcatcc tagagtccca gcacaccctg
     1501 tcgcagtttg cagagaagat ctctaaactc ccggaagtgc aaagcaagta cttcgagatg
     1561 ctggagtttg tcgtcttcag cctgaactac atcccctgta aagagctcat cagcgtcagc
     1621 atcctgctca agtccagctc ttcgcaccac tgcagcatcg tggcgatgaa gaccctcctg
     1681 aagttcacaa ggcacgacta catattcaaa gacgtcttca gggaggtggg cctgctggag
     1741 gtcatggtaa accttctgca taagtacgcg gccctcctga aggatccagc tcaggcgctc
     1801 ggtgagcagg gggactcaag aaacaatagt tcagttgaag accaaaagca cttggctctg
     1861 ttggtgatgg aggccttgac tgtgctgctt caagggtcca acacaaacgc aggaatattc
     1921 cgcgagtttg gcggtgcaag gtgcgctcac aacattgtga aatacccgca gtgccgacag
     1981 cacgccctga tgaccatcca gcaactggtg ctctctccca atggggagga tgacatgggc
     2041 actctcctgg ggctcatgca ctcagcccca cccacggagc tgcagctgaa gaccgacatc
     2101 ttaagggccc tgctgtccgt ccttcgagaa agccaccgtt cgagaaccgt cttcaggaaa
     2161 gttggcgggt ttgtgtacat cacatccttg ctcgttgcta tggagagatc tctgagctct
     2221 cctcccaaga atggctggga gaaagtgaac cagaaccaag tgtttgagct cctgcacact
     2281 gtgttctgca cgctgactgc cgctctgcgc tacgagccag ccaactctca cttcttcaag
     2341 accgagatcc agtacgaaaa gctggcggat gccgtccggt ttctcggatg cttctcagac
     2401 ctcaggaaaa taagtgccgt gaacgtcttc ccctcaaata cttcgccttt ccagagactg
     2461 ctggaggaag gggcggtgcc catggactcc gtgtcaccta ccctgcggca ctgcagtaaa
     2521 ctcttcatct atctctacaa agtggccacc gattctttcg acagtcgcac agagcagatc
     2581 cctccttgcc tgacaagcga gtcttctctc ccctctcctt gggggacacc agctttgtcc
     2641 aggaaaaggc atgcatttca ctgcgtttca actccacctg tgtaccctgc gaaaagcgtc
     2701 accgacctaa aacttcaggt gacaagctca cccctgccga gctccgaggc cgtcatcatc
     2761 caccccgggg ccatgttagc catgctcgac ttgctggcct ctgtgggctc agtgacacag
     2821 ccagaacatg ctttggacct tcaacttgcc gtggccaata ttttacaatc cctggtgcac
     2881 acggagcgga accaacaggt catgtgtgaa gccggtcttc acgcacggtt gctgcagagg
     2941 tgcggcgctg cactagccga cgaggaccac tcgctgcacc ctcccctgca gcgcatgttt
     3001 gaacgcttgg cctcccaggc cttggaaccc atggtgctga gggagttttt gcgtttggca
     3061 agccctctga actgtggtgc gtgggacaaa aagctgctga aacagtacag ggttcacaaa
     3121 ccaagttcgc tgagcttcga gccggacatg agaagtagcg tggtcacctc tctggaaggt
     3181 ctgggctccg acagcgtttt cagctcacat gaagataacc attaccggat aagcaaaagt
     3241 ctggtgaagt ctgcagaagg aagcactgtg cccttgacca gggtgaagtg tctcgtctcc
     3301 atgacaaccc ctcatgacat cagacttcat ggttcatctg ttactccagc tttcgttgaa
     3361 tttgacacat cccttgaagg ctttggctgc ctgtttctac ccagcctggc tccccacaac
     3421 gcccctacca acaatgccgt cacgacaggt cttaccgatg gggccgtggt cagcggtatt
     3481 ggctctggcg agaggttctt ccccccgcct tctggcctaa gctattcctg ctggttctgc
     3541 atcgaacact tcagctcccc tccaaataac cacccggtca gactcctcac tgttgtgcgg
     3601 cgagcgaatt catccgagca gcattatgtg tgccttgcca tcgttctgtc tgcgaaagac
     3661 cggtccttaa tcgtctccac gaaggaggag ctgctccaaa attacgttga cgatttcagt
     3721 gaagagtcct ctttctatga gatcctcccg tgctgcgccc gctttcggtg tggagagctg
     3781 gtggtggagg gacagtggca tcacctggct ctgctgatga gcagaggcat gctcaagaac
     3841 agcacggcgg ccctctacat cgacggccag ctggtcagca ccgtcaagct gcattatgtc
     3901 cacagcacgc ctgggggctc gggctctgca aaccccccag tgctgagcac agtctacgct
     3961 tacatcggca ctccacctgc acagcggcag atggcctcac tggtctggcg cctggggccc
     4021 actcattttc tggaagaagt tttacctccc tccagcgtga ccgctattta tgaactggga
     4081 ccagactatg tgggaagctt tcaggctgtc ctcgtgccat gtaaagactc gaaatcggaa
     4141 ggtatcatcc catcgccggt gtctctggtc gcagaggaaa aggtgtcatt tggactttac
     4201 gccctgtccg tgtcctcact cacagtggca agaatcagga aagtctacaa caagttggac
     4261 agcaaagcca ttgcaaagca gttaggcatt tcctcccatg agaacgccac acccgtgaag
     4321 ctggttcaca atgcagccgg ccatctcaat gggccagctc gcaccatcgg ggctgctctc
     4381 attggatact tgggggtaag gacgtttgtc ccgaagccgg tcgccaccac cctgcagtac
     4441 atcggaggag ctgcagccat cctcggtctg gtggccatgg cctctgatgt ggaaggcttg
     4501 tatgcagccg tcaaggcgct ggtctgtgtg gtcaagagca acccgctagc cagcaaggag
     4561 atggaaagaa tcaaagggta ccagctgctg gccatgctgc ttaaaaagcg acgctccctt
     4621 ctcaacagcc acatcctcca cctgaccttc tccctggtgg ggacggttga cagtggccac
     4681 gagacttcca ttattcccaa ctccactgcc ttccaggacc tgctctgtga cttcgaggtc
     4741 tggcttcatg ctccgtacga gctccatctt tctttatttg aacacttcat agagctgctc
     4801 acagagtcca gtgaggcttc caagaatgcc aagttaatga gggaatttca gctgatcccc
     4861 aagctgctcc tgacgctccg agacatgtcc ttgtcccagc cgaccattgc tgccatgagt
     4921 aacgtgctga gccacctgct gcagggcttc cctaacagca acgatctgct caggtttggc
     4981 cagttcattt cttctacttt gcccaccttt gccgtctgtg agaaattcgt ggttatggaa
     5041 atcattaatg aagggaaacc tgactctgga gcagaagagg agtttggagg tcttgtgtct
     5101 gctaacctta tacttctgag gaacagactt ctagacatct tgctaaagct agtttatacg
     5161 tccaaagaaa agacaaacat aaacttacag gcttgtgaag agctggtcag gacgctgggt
     5221 ttcgactgga tcatgatgtt catggaagaa cacttgcatc ccaccacagt cacggccgcc
     5281 atgaggattc tcgttgtcct gctgagtaac cagtccattc tcatcaaatt taaagaggga
     5341 ctcagtggcg ggggctggct ggagcagaca gactccgtcc tgacaaacaa gatcggaact
     5401 gtgttaggat tcaatgtggg caggagtgcc ggagggagat ccacggtcag ggagattaac
     5461 cgggatgcct gccattttcc cgggttcctg gttcttcagt ctttcctccc taagcacaca
     5521 aatgtccctg ccctctattt tctccttatg gccttgtttc tgcaacagcc agtgagtgag
     5581 ctgcccgaga acctgcaggt cagtgtgcct gtcaccaaca gccgatgtaa gcagggctgc
     5641 cagtttgacc tggactctat ctggacgttt atcttcggcg tcccggcctc cagcgggacg
     5701 gtggtgtcct ccatccacaa cgtgtgcacc gagtctgctt tcctgctgct cgggatgcta
     5761 cgaagtatgc tgaactcgcc ctggcagtca gaagaggagg gttcgtggct gcgagagtac
     5821 ccggtgaccc tgatgcagtt ttttcggtac ctgtaccaca acgtcccaga cctcgcctcc
     5881 atgtggctga gccccgactt cctgtgtgcc ttagcagcca ccgtcttccc cttcaacatc
     5941 cgcccgtact cagagatggt gacagatctg gatgatgagg ttgggtctcc agcagaagag
     6001 tttaaagcgt tcgcggcaga cacggggatg aacaggagcc agtcagagta ctgcaatgtg
     6061 ggcaccaaga cctatctgac caatcaccca gccaagaagt tcgtcttcga cttcatgcga
     6121 gtcttgatca ttgacaacct ctgccttacc ccggccagca agcagacgcc gctgattgac
     6181 ctgttgttgg aggcgtcccc tgagagatcc acaagaacgc agcagaagga gttccagacg
     6241 cacatcttgg acagtgtgat ggaccatttg ctcgcggctg atgtgttgtt gggggaagac
     6301 gcatctctgc ctattaccag tggaggaagc taccaggtat tggtgaacaa cgtgttttat
     6361 ttcacgcagc gcgtggtgga caagctttgg caaggcatgt tcaacaaaga atctaagctc
     6421 cttatagatt ttataattca gctcattgcc cagtccaaga ggcgatcgca gggcttgtcg
     6481 ctggatgcag tgtatcactg cctcaatcgg accatcctgt accagttctc ccgtgcgcac
     6541 aaaaccgtcc cacagcaagt agcgctcctg gattcactcc gggtccttac tgtgaaccgg
     6601 aacttaatcc tgggacccgg aaaccacgac caagaattca ttagctgtct tgctcactgc
     6661 ctgattaatc tacatgctgg aagcagtgtg gaaggctttg ggctggaagc cgaggcacgc
     6721 atgaccacgt ggcacatcat gattccctcg gacatcgagc cagacggtgg ctacagccaa
     6781 gacatcagtg aagggcggca gcttctcatt aaagctgtca acagggtttg gactgagctg
     6841 atccacagta agaaacaagt cctggaggaa gtcttcaagg tcagcctgcc cgtgaacgac
     6901 aggggccacg tggacatagc cgtggcacgg ccactcatcg aggaggctgg tctcaagggc
     6961 tggcagaatc atctggccca cgaaaagaag tgcataagtc gaggagaagc cttggtgcct
     7021 accacgcagt ccaaactgtc ccgggtgagc agcggctttg gcctgtccaa gctaacggga
     7081 tcaagaagga accgaaagga aagcggcctc cacaaacaca gcccttctcc ccaggagatt
     7141 tcccagtgga tgttcacaca catcgctgtc gtgcgggacc tggtggacac gcagtacaag
     7201 gagtatcagg agcgccagca gaatgctctg aagtatgtga ctgaggagtg gtgtcagatc
     7261 gagtgtgagc tgttgcggga gcgagggttg tggggccccc ccatcggctc ccacctagac
     7321 aaatggatgt tagagatgac ggaggggccc tgcagaatga ggaagaaaat ggtgcgcaat
     7381 gacatgttct acaaccacta tccttacgtg ccggaaacgg agcaggaagc cagcgtgggg
     7441 aaacctgctc ggtaccgaag ggccataagc tatgacagta aagagtacta cctccgcctg
     7501 gcctctggta accccaccat tgtgcaggat gctattgtag agagttctga aggagaagcc
     7561 acccagcaag aaccagagca cggggaagac accattgcca aggtcaaagg cctggtgaag
     7621 ccacccctga agcgctctcg gtctgcgcct gatggaggag acgaggagac ccaggagcag
     7681 ctccaagacc agatcgccga gagtggctcc atagaggagg aggagaaaac agacaatgcc
     7741 accttgctgc gcctgctgga ggagggagag aagattcagc acatgtaccg ctgtgctcga
     7801 gtccagggcc tggacaccag tgaggggctg cttctctttg gtaaagagca tttctatgtg
     7861 atcgatggct ttaccatgac tgccaccagg gaaataagag acatcgaaac cttacctcca
     7921 aacatgcatg aaccgattat cccccgaggc gccaggcaag gccccagcca actcaagaga
     7981 acgtgcagta tcttcgcgta cgaagacatc aaggaggttc ataagaggag gtatctgctg
     8041 cagcctattg ctgttgaagt tttctctgga gatggacgga attacctcct ggcttttcaa
     8101 aagggaattc ggaataaagt ctaccaaagg ttcctggcag ttgtgccctc cctcaccgac
     8161 agctcagagt ctgtgtctgg gcagagaccg aacaccagtg tggaacaagg gtctggctta
     8221 ctcagcaccc tggttggaga gaagtctgtg actcagaggt gggagagagg tgaaatcagc
     8281 aacttccagt atctgatgca cttgaacacc ctggccggca ggtcctacaa cgaccttatg
     8341 cagtaccctg tcttcccctg gatcctcgca gattacgact ccgaggaagt tgacctcact
     8401 aaccctaaga cattcagaaa cctggctaag ccaatgggcg cgcagacgga tgagcgactg
     8461 gcccagtaca agaagcgcta caaggactgg gaggatccca atggggagac cccagcctac
     8521 cactacggca cccactactc ctccgccatg attgtggcct cgtacctcgt gaggatggag
     8581 cccttcacac agatattcct acggcttcag ggtggtcact ttgacctggc agaccggatg
     8641 ttccacagtg tccgtgaggc ctggtactca gcatcaaagc acaacatggc ggatgtgaaa
     8701 gaactcatcc cagaattttt ctacctgccg gaattcctgt tcaattctaa caactttgac
     8761 ctaggctgca aacagaatgg caccaagctt ggagatgtta tccttccacc ctgggcaaag
     8821 ggggacccga gagagttcat ccgcgtccac cgtgaggctc tggagtgcga ctacgtgagt
     8881 gcccacctgc acgagtggat cgacctcatc ttcggctata agcagcaggg ccccgcggca
     8941 gtggaggctg tgaacgtctt ccatcacctt ttctacgagg gccaagtgga tatctacaac
     9001 ataaacgacc cgctaaagga gacggccacc atcggcttca ttaacaactt cggtcagatc
     9061 cctaagcagt tgtttaaaaa gcctcatcca ccaaagcgag tacggagtcg gctgaacgga
     9121 gagaatgcag gcctctctgt cccaccagga gccaccagcg acaagatctt tttccatcac
     9181 ctagacaacc tgaggccttc cctaacaccc gtgaaagaac tcaaagagcc cgtggggcag
     9241 atcgtgtgca cagataaagg cattctcgcc gtagagcaga acaaggtgct catcccccct
     9301 gcttggaaca agaccttcgc ctggggctat gcagacctca gctgccgcct ggggacctac
     9361 gagtcagaca aggcagtggc tgtgtatgaa tgtctgtccg aatggggcca gattctctgt
     9421 gcagtttgcc ccagccccaa gctcgtcatc acgggtggaa caagtacagt ggtgtgcgtc
     9481 tgggagatgg gcacctccaa agaaaaggcc aagcccctga cgctcaagca ggctctactt
     9541 ggccacactg atactgtcac ctgtgccaca gcctccatag cctaccacat cattgtcagc
     9601 gggtcccgag accgaacctg catcatctgg gacctgaaca aactgtcgtt tctcacccag
     9661 ctccgtggcc accgagcgcc cgtctccgcc ctttgcatta atgagttaac aggggacatc
     9721 gtgtcctgtg ctggcacata cgtccacgtg tggagcatca acgggaaccc cattgtgagc
     9781 gtcaacacct tcacaggccg gagccagcag atcgtctgct gctgcatgtc cgagatgaat
     9841 gaatgggaca cgcagaatgt catcgtgaca gggcactcag atggagtggt ccggttctgg
     9901 agaatggaat tcctgcaggt tccggaaaca ccagctcctg agcctgtcga agacctggag
     9961 atgcaggaag gctgcccgga agcacagata gggcagcaag cccaagatga agacagcagt
    10021 gattctgagg cagaagagcc cagtgtcagc caggatccta aggacacgcc cagccagccc
    10081 agcagcacca gccacaggcc tcgggcagcc tcctgcagag ccaccgccac atggtgcact
    10141 gacagcggct ctgatgactc ccggcgctgg tccgaccagc tcagtcttga tgagaaagat
    10201 ggcttcatat ttgtgaacta ttcagagggc caggccagag cacatcctca gggctcccac
    10261 tcccacccca accccactga agcacgaagt tacagcagat tgaaacctgg gtaccggtgg
    10321 gagcggcagc tggtgttcag aagcaaactg actatgcaca cggcctttga tcggaaggac
    10381 aacactcatc cagctgaggt caccgcactg ggtgtctcca aggatcacag caggatcctc
    10441 gtgggtgaca gccgaggccg agtgttcagc tggtctgtga gtgaccagcc tggccgttct
    10501 gcggccgacc actgggtgaa ggacgaaggt ggtgacagct gttcaggatg ctctgtacgc
    10561 ttctccctca cagagagaag gcaccattgc aggaactgcg ggcagctctt ctgtcagaag
    10621 tgcagtcgat ttcagtcaga aataaagcga ctgaaaatct cgtccccagt gcgtgtctgc
    10681 cagaactgct actatagctt acagcacgag aggggggcag acgatgggcc tcggaactgc
    10741 tgagacagac ggcgggactg acgagaggcc acagcctgaa ggagctcttc ctgccccgtc
    10801 atggctccaa aggcactgaa gcagactccg tttacacaga tctgcacact gagtgtctga
    10861 agtgttgagt tcaaagggat cattggatcg ggttccgagg ccagtgaccg gcacgggcac
    10921 taaaccgtta gcagcacaag aacgcaaggt ggtcccggag catctcagaa cccgagtctc
    10981 ccatagcgta gctgtctccg agagcaaact cctgctcccc aactgtcttt cttgtatctc
    11041 atttttatag agctattcat ccttatttgg aaaaatcaac aaaaacttta aaaaaaaagg
    11101 cttctagaaa atggttgtaa atctgacttc tttgcaagca gctgtgtata ttgtaaatag
    11161 gtataaaggc cttttttttt ttctaaataa ggacctaatt gcctgtaaca tgagacttca
    11221 aactaagcca ctaactcaat gaaccattta aggtctgtct aacgtctctc aattataaat
    11281 atggggtttt tctaatcctc agagacattg tctttttttt tttttttttt tttttttttc
    11341 ctgttcagac caagcctgtg tgcctgatgt cacttctttc aagttgccca cagcgtctcc
    11401 acttaagata ggctagtcac caaaatcctg tagccctgct ttaggagctg gtgtgggagg
    11461 agagaggtct ggtcataagg tagccgcaga tagccagcac cggtctgagg ctgcttactg
    11521 ctccagtgta gtagttgtgt gcccgacccc tgaaactgac cctcgggctg tgtggtccca
    11581 gcccggcccg gcatcacgga aaggggatca cacaatggat gtccggcagg atgcagccct
    11641 gcctcagtta acggaaatat atttgcatgt caccccaaat tagcttctct gcatagaaca
    11701 taacaagtgt gtgtatttgg ggacacgtgt gttctactac agcttatttt cggaagaaaa
    11761 aaaggtgtac agaattaaca ttcaaacctt gtaaaactgg atcatgtcag aagtgcttca
    11821 aatgaacctt taccgtttca tgccatctac ctgaaaacag tgagatttat actgtaccaa
    11881 tgtctatttt tttggttttg ctatgaatat aattacagta ttttaatatt tagttattta
    11941 atttgttgta ctagttggat accgaaggca cacattcagg aggatgaaag ctggtcgggg
    12001 ctaagagacg tttataggaa aatggctttg gtggtgggat ttttttaaat gtgtgttatg
    12061 tacataaata taaatatata tatatatatg aaatcgaaac aattaatcta gattttaaca
    12121 ttttcagata cttagcacta atactatgaa caattctaaa agccctgtga tttgaacaac
    12181 atgggttcac taatggccca agaaagaaag gacaggcctt gacaccctca cagagggagg
    12241 tttctagcaa aggacagtgg ctttggcttc cctcactctc catctttagc cctggtgaca
    12301 ggcacactta tgcactaaat gcacatatat gcacatgtgt ccagaaacag gcatgtggta
    12361 caacggtgac cttgtaccct atgggctgaa agcagctgca gaacaaactt gttcttcctg
    12421 acaagcaggt ctccaggaga aacggtgaag gctgctttag tgccttatgc ttcctaaatt
    12481 taaaccttcc tttataggtt tcagcctcca gtctgtgata catatcagaa ttgactcaaa
    12541 cacttccatt tctaaacgct caaatacaca cgtgaacaaa aggattgtcg gcattaacgc
    12601 tttccacttg aaaacttgct ttgctttctc ctcctcttcg gtgtctcaca ccccgccccc
    12661 cgcctcccct acctctccct tccccctccc cccacgaccc ccccccctcc cgctccccca
    12721 gcccgtccct gtcttcagaa ggactctggt gttcctccac tgcagaaact gcttttgcat
    12781 ggtggtgggc tggccctggc tgcctctgga tgctttgcaa cagtgttact ttacactttt
    12841 gaaaagcagc gccctcctgt ggcagaggtg ttttcaagac ttgaacttag gagtgtgtgt
    12901 gtagccactt gaagcttgtt ccgctgtcta acctgactga cgtgctgtgg gacaaaggct
    12961 cttcaacttt ccagcccaac tcccataact agtaggtgga aaccaaaccc ctccttccct
    13021 ctggcagctg gtgctgtggg caactgtctt gtttccacca gcttttggtt tttgttttct
    13081 tttcacttct gcagaaatca cagagccact cctccctccc cccgggcact gggctccatt
    13141 gctcgtctgg ctatgtatcc cccgtgttct gtgccaatct gcttaccaat atacacgatg
    13201 tgtgtccacc ttcccgtggt ctgcattctt tttctaagta cctcacaggg ctccagcctg
    13261 acctctgttc acccttcacc catccaccca ctgctcatcc atgcactcaa cacacacccg
    13321 agtgtagtgt gcaagtgtga cgtcatgctt ttgaagacga gaagtagctg cccgtagcag
    13381 ccagccctct ggagaatagc aaaacactct agataagtta ttttgcactt tcttatgtat
    13441 aaaggtggta gaaacttatt tttgctttgt atcatttaaa tacattttgt ttttggtaaa
    13501 caactgtgta taaaatattt acgctgttaa agctgttttt agaaagtatt tttaatttca
    13561 gcaagtttgc ttacttgttg catgaccatt aacacaactg actttttgtg tcagtgccat
    13621 gtatatttct gtcctgtcat taacttgtaa gccctagtaa cggctaatcg tttgtacagc
    13681 aacagaagta aaccgaagat actggctaag actggattga ttgtggactt ttgtactgta
    13741 ttgcaaaatc cgatctctgt ttctctggtg gttgtgtaaa ggctgaggaa ttcctaccat
    13801 gtgcagtctg tggtctgggt gttcactgta tctctgtctg atgcataaag gtaggcagtc
    13861 gcagcccgtg ctaaatgcaa tagtccaggt acttaagtat ttttttcatt tcaaataaat
    13921 acctactatt taccacaaaa aaa
//
LOCUS       NM_001437050             502 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S5
            (Ndufs5), transcript variant 1, mRNA.
ACCESSION   NM_001437050 XM_006238827
VERSION     NM_001437050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 502)
  AUTHORS   Huang,G., Chen,Y., Lu,H. and Cao,X.
  TITLE     Coupling mitochondrial respiratory chain to cell death: an
            essential role of mitochondrial complex I in the interferon-beta
            and retinoic acid-induced cancer cell death
  JOURNAL   Cell Death Differ 14 (2), 327-337 (2007)
   PUBMED   16826196
REFERENCE   4  (bases 1 to 502)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 502)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 502)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006238827.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM090517.1, BP489095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000005.1  141264349-141264418 c
            71-288              JAXUCZ010000005.1  141261991-141262208 c
            289-502             JAXUCZ010000005.1  141258828-141259041 c
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..502
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="NADH:ubiquinone oxidoreductase subunit S5"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
     exon            1..70
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    67..69
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="upstream in-frame stop codon"
     exon            71..288
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..393
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 5b,
                     15kDa (NADH-coenzyme Q reductase)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 5"
                     /protein_id="NP_001423979.1"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
                     /translation="MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECA
                     HGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLMKEGKYTPPPHHLGKE
                     EPRP"
     misc_feature    73..360
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     misc_feature    73..360
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="mitochondrial complex I subunit NDUFS5 and similar
                     proteins; Region: NDUFS5-like; cl10892"
                     /db_xref="CDD:472051"
     exon            289..502
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtctgc gtcctcctta agccggcggt cgtgagctgc gcccagggac ctgagaaggg
       61 cattgctgag tcatgccttt ccttgatgtg cagaaaaggc tgggcattag cctagatcga
      121 cactttatat tcctaagtgc tgagcagcct tacaagaatg ccgctcgatg ccacgcattt
      181 gaaaaggagt ggatagaatg cgcacatggg atcggtgcta cccgggctaa aaaagagtgc
      241 aagatagagt atgaagactt tgaagaatgc tttcttcggt tcaaaacgat aaggcggatg
      301 catgaaatca agaaacagcg ggagaagctg atgaaagagg ggaagtacac ccctccgcct
      361 caccatttgg gcaaggagga gcccaggccc tgagcagagc agctagaagc tgctctccat
      421 gctctgtttt ccgctggaga gaatgtttaa gggaagcacc ttcatcaagt atgtacaaat
      481 aaagaattac tcaacctaga aa
//
LOCUS       NM_001109096            2886 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 75 (Gpr75), mRNA.
ACCESSION   NM_001109096 XM_001066164 XM_006251616 XM_573685
VERSION     NM_001109096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Liu,B., Hassan,Z., Amisten,S., King,A.J., Bowe,J.E., Huang,G.C.,
            Jones,P.M. and Persaud,S.J.
  TITLE     The novel chemokine receptor, G-protein-coupled receptor 75, is
            expressed by islets and is coupled to stimulation of insulin
            secretion and improved glucose homeostasis
  JOURNAL   Diabetologia 56 (11), 2467-2476 (2013)
   PUBMED   23979485
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Ignatov,A., Robert,J., Gregory-Evans,C. and Schaller,H.C.
  TITLE     RANTES stimulates Ca2+ mobilization and inositol trisphosphate
            (IP3) formation in cells transfected with G protein-coupled
            receptor 75
  JOURNAL   Br J Pharmacol 149 (5), 490-497 (2006)
   PUBMED   17001303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 25, 2025 this sequence version replaced
            XM_006251616.5, NM_001109096.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.56130.1,
                                           SRR26360172.136069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000014.1  108811896-108812065
            171-2886            JAXUCZ010000014.1  108817086-108819801
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2886
                     /gene="Gpr75"
                     /note="G protein-coupled receptor 75"
                     /db_xref="GeneID:498434"
                     /db_xref="RGD:1566385"
     exon            1..170
                     /gene="Gpr75"
                     /inference="alignment:Splign:2.1.0"
     exon            171..2886
                     /gene="Gpr75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    243..245
                     /gene="Gpr75"
                     /note="upstream in-frame stop codon"
     CDS             270..1892
                     /gene="Gpr75"
                     /note="G protein-coupled receptor GPR75"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 75"
                     /protein_id="NP_001102566.1"
                     /db_xref="GeneID:498434"
                     /db_xref="RGD:1566385"
                     /translation="MNSSAPLQNVPNATLLYTPPLQGGNNTSLQEGLRDFIHTATLVT
                     CTVLLAIIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGATAPMFT
                     FVLFFSSARSIPDSFCFTFHLTSSGFIIMSLKMVAVIALHRLRMVMGKQPNCTASFSC
                     ILLLTLLLWATSFTLATLATLRTSKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVV
                     SVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQN
                     YNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAVVTCMVIVLSVLVCC
                     LPLGISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLR
                     YTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQACGPSH
                     SKESVASPKVSAGHHPCGQSSSTPINTRIEPYYSIYNSSPSQQESSPANLQPVNSFGF
                     ASSYIAMHYYTTNDLMQDYDSTSAKQIPIPSV"
     misc_feature    399..1430
                     /gene="Gpr75"
                     /note="G protein-coupled receptor 75, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR75; cd15007"
                     /db_xref="CDD:320136"
     misc_feature    399..1430
                     /gene="Gpr75"
                     /note="G protein-coupled receptor 75, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR75; cd15007"
                     /db_xref="CDD:320136"
     misc_feature    399..479
                     /gene="Gpr75"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320136"
     misc_feature    399..479
                     /gene="Gpr75"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320136"
     misc_feature    504..581
                     /gene="Gpr75"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320136"
     misc_feature    504..581
                     /gene="Gpr75"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320136"
     misc_feature    order(570..572,579..584,621..638,642..647,654..656,
                     786..788,792..806,864..866,873..881,885..893,897..902,
                     1269..1271,1278..1283,1287..1292,1299..1301,1329..1334,
                     1338..1346,1353..1355,1362..1367)
                     /gene="Gpr75"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320136"
     misc_feature    order(570..572,579..584,621..638,642..647,654..656,
                     786..788,792..806,864..866,873..881,885..893,897..902,
                     1269..1271,1278..1283,1287..1292,1299..1301,1329..1334,
                     1338..1346,1353..1355,1362..1367)
                     /gene="Gpr75"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320136"
     misc_feature    621..713
                     /gene="Gpr75"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320136"
     misc_feature    621..713
                     /gene="Gpr75"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320136"
     misc_feature    744..812
                     /gene="Gpr75"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320136"
     misc_feature    744..812
                     /gene="Gpr75"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320136"
     misc_feature    864..953
                     /gene="Gpr75"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320136"
     misc_feature    864..953
                     /gene="Gpr75"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320136"
     misc_feature    1209..1301
                     /gene="Gpr75"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320136"
     misc_feature    1209..1301
                     /gene="Gpr75"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320136"
     misc_feature    1332..1409
                     /gene="Gpr75"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320136"
     misc_feature    1332..1409
                     /gene="Gpr75"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320136"
ORIGIN      
        1 gcctaggctc ccgggatgcg tggaggcggc ggcgatgacg gtgatgactc tagcccggca
       61 gcatccaggc caccgggcgc agatagggtc gagcatccag gccaccgggc gcagataggg
      121 tcgctgctgc gacatggagg aggaagggcg gcgctgcggc cagctggcag gcttatcttc
      181 ctccgccata catgcccatc gtctgtgagc tgagatcctg actctcttcc tgctgatgtt
      241 tttaaaacac aagagacact tctctgaaga tgaattcaag tgccccgctt cagaatgttc
      301 ccaatgccac cttgctatac acacctcccc tgcagggagg aaataacact tctctccagg
      361 agggtcttcg agattttatc cacacagcca ccttggtgac ctgcacggtc ctgcttgcca
      421 tcatcttctg tctaggctct tatggaaatt ttattgtctt cttgtctttc tttgacccgg
      481 ccttcagaaa gttcagaact aactttgatt tcatgatctt gaacctgtct ttctgtgatc
      541 tgttcatctg tggggccaca gcccccatgt tcacctttgt gctgttcttc agctcagcca
      601 ggagcatccc agacagtttc tgcttcacct tccaccttac cagctcaggt ttcatcatca
      661 tgtccctcaa gatggtagct gtgattgccc tgcaccggct ccggatggtg atggggaagc
      721 agcctaattg caccgcttcc ttttcctgca tcttgctcct tacccttctt ctctgggcca
      781 ccagctttac acttgccacc ttggctacac tgagaaccag taagtcccac ctgtgtctcc
      841 ccatgtccag tcttatggac ggggaaggga aggccattct gtctctgtat gttgttgact
      901 ttaccttctg tgtggccgtg gtgtctgtct cttatatcat gattgctcaa acccttcgga
      961 agaatgccca agtaaaaaag tgcccccctg tgatcacagt tgatgcttcc agaccacagc
     1021 cattcatggg ggcctctgtg aagggaaatg gagatcccat ccagtgcacc atgccagctc
     1081 tgtataggaa ccagaattat aacaaactgc agcacaatca aactcatgga tacactaaga
     1141 atgccaacca gatgccaatc ccctcagcca gtcggctcca gctggtatca gcggtcaacc
     1201 tctctactgc caaggattcc aaagctgtgg tcacctgcat ggtcatcgtg ttgtcggttc
     1261 tagtgtgctg tcttcctctg gggatttccc tgctgcaagt ggttctgtct gacagtggca
     1321 gcttcatcct ttaccagttt gagttatttg gatttactct gatatttttc aagtcaggat
     1381 taaatccttt tatatattct cggaacagtg ctgggctgag aaggaaagtg ctctggtgcc
     1441 tgcgatacac tggcctgggc ttcctctgct gcaaacagaa aactcgactt cgggccatgg
     1501 ggaaagggaa ccttgaaatc aatagaaaca aatcctccca tcatgagaca aactctgcct
     1561 acatgctgtc tccaaaacca cagaagaaat ttgtagacca ggcttgtggc ccaagtcatt
     1621 caaaagaaag tgtagcaagt cccaaagtct ctgctggaca tcacccctgt gggcagagca
     1681 gctcgacacc catcaacact cggattgaac cttactatag catctataac agcagcccgt
     1741 cccagcagga gagcagccca gcaaacctgc agccagtgaa ctcttttggt ttcgccagtt
     1801 cctacatcgc catgcactat tacaccacca atgacttgat gcaggactat gacagcacgt
     1861 cggcaaaaca gatccctatc ccttctgttt aatacagcca gagaatctgg agggaatggt
     1921 tttctctctg gactgaacaa acctttaaaa gagcttgagt tccatggcaa aacaaaacct
     1981 ggaatcaact gaagacttga ctttctttca cctgaagtat tagtatccgg gttggcttca
     2041 tggtttcttg acattttaag atttagtgta aaagtttagt tcaatttata ctctgaccca
     2101 tgtcccaata ctttatacta aactgctaaa aagatgtcag ggactattct attaatgaca
     2161 cccttttaag tcagtattat gggattttag atatgtattg actacatttt ctttctttcc
     2221 actaatttat ttatttattc actttacatc ccgattgaag ccccacctct cctcccagta
     2281 ctccctctca tggtccctct cccaatttct cctccccttt atttctgagg aggaggaggt
     2341 ccctcctggg gaaacaacct tcctcaagtc actgaaggac taggtacatc ctctgccact
     2401 gaggccagac gtgctagccc aattaggagc aggattcaca gacaggaaac agtcagggac
     2461 agtcagcact ctactcattg ggggacccat ataaagacca agctgcacct ctgttacaaa
     2521 tgtgctggtg ggcctaggac cagcctcttt ggctagtggt tcagtacctg ggagccttca
     2581 aggatccagg ttagttggta ttctgaagga gtacctgttc cctccaggtt cctctatcct
     2641 ttctccaacc cttccacaag acttcccaag ctccagtcta atgtttggct gtgggactgc
     2701 atttgtttct gtcaactgct gtaatttggc tacattttta aaatggtgtt tgaaaaaaat
     2761 tatctttctg aagtgttatt tttataaaaa tatggaatta gtgtctttga agtactgaaa
     2821 cagcaaacag tgtacttttt tggtggcaag tggtttaaat aaaaaactta ctgttaaaac
     2881 agaaaa
//
LOCUS       NM_001437097            7151 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus transcription factor 4 (Tcf4), transcript variant
            21, mRNA.
ACCESSION   NM_001437097 XM_039097158
VERSION     NM_001437097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7151)
  AUTHORS   Sirp,A., Roots,K., Nurm,K., Tuvikene,J., Sepp,M. and Timmusk,T.
  TITLE     Functional consequences of TCF4 missense substitutions associated
            with Pitt-Hopkins syndrome, mild intellectual disability, and
            schizophrenia
  JOURNAL   J Biol Chem 297 (6), 101381 (2021)
   PUBMED   34748727
  REMARK    GeneRIF: Functional consequences of TCF4 missense substitutions
            associated with Pitt-Hopkins syndrome, mild intellectual
            disability, and schizophrenia.
REFERENCE   2  (bases 1 to 7151)
  AUTHORS   Li,N., Liu,B., Wu,W., Hong,Y., Zhang,J., Liu,Y., Zhang,M., Zhang,X.
            and Duan,G.
  TITLE     Upregulation of transcription factor 4 downregulates NaV1.8
            expression in DRG neurons and prevents the development of rat
            inflammatory and neuropathic hypersensitivity
  JOURNAL   Exp Neurol 327, 113240 (2020)
   PUBMED   32045596
  REMARK    GeneRIF: Upregulation of transcription factor 4 downregulates
            NaV1.8 expression in DRG neurons and prevents the development of
            rat inflammatory and neuropathic hypersensitivity.
REFERENCE   3  (bases 1 to 7151)
  AUTHORS   Han,F., Liu,W.B., Shi,X.Y., Yang,J.T., Zhang,X., Li,Z.M., Jiang,X.,
            Yin,L., Li,J.J., Huang,C.S., Cao,J. and Liu,J.Y.
  TITLE     SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling
            via Transcriptional and Posttranslational Regulation of
            beta-Catenin in Lung Cancer
  JOURNAL   EBioMedicine 31, 253-266 (2018)
   PUBMED   29739711
REFERENCE   4  (bases 1 to 7151)
  AUTHORS   Sepp,M., Vihma,H., Nurm,K., Urb,M., Page,S.C., Roots,K., Hark,A.,
            Maher,B.J., Pruunsild,P. and Timmusk,T.
  TITLE     The Intellectual Disability and Schizophrenia Associated
            Transcription Factor TCF4 Is Regulated by Neuronal Activity and
            Protein Kinase A
  JOURNAL   J Neurosci 37 (43), 10516-10527 (2017)
   PUBMED   28951451
  REMARK    GeneRIF: TCF4-controlled transcription in primary cortical neurons
            is induced by neuronal activity and protein kinase A.
REFERENCE   5  (bases 1 to 7151)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 7151)
  AUTHORS   Chen,B. and Lim,R.W.
  TITLE     Physical and functional interactions between the transcriptional
            inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism
            regulating muscle-specific gene expression
  JOURNAL   J Biol Chem 272 (4), 2459-2463 (1997)
   PUBMED   8999959
REFERENCE   7  (bases 1 to 7151)
  AUTHORS   Pscherer,A., Dorflinger,U., Kirfel,J., Gawlas,K., Ruschoff,J.,
            Buettner,R. and Schule,R.
  TITLE     The helix-loop-helix transcription factor SEF-2 regulates the
            activity of a novel initiator element in the promoter of the human
            somatostatin receptor II gene
  JOURNAL   EMBO J 15 (23), 6680-6690 (1996)
   PUBMED   8978694
REFERENCE   8  (bases 1 to 7151)
  AUTHORS   Yoon,S.O. and Chikaraishi,D.M.
  TITLE     Isolation of two E-box binding factors that interact with the rat
            tyrosine hydroxylase enhancer
  JOURNAL   J Biol Chem 269 (28), 18453-18462 (1994)
   PUBMED   7913462
REFERENCE   9  (bases 1 to 7151)
  AUTHORS   Corneliussen,B., Thornell,A., Hallberg,B. and Grundstrom,T.
  TITLE     Helix-loop-helix transcriptional activators bind to a sequence in
            glucocorticoid response elements of retrovirus enhancers
  JOURNAL   J Virol 65 (11), 6084-6093 (1991)
   PUBMED   1681116
REFERENCE   10 (bases 1 to 7151)
  AUTHORS   Henthorn,P., Kiledjian,M. and Kadesch,T.
  TITLE     Two distinct transcription factors that bind the immunoglobulin
            enhancer microE5/kappa 2 motif
  JOURNAL   Science 247 (4941), 467-470 (1990)
   PUBMED   2105528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039097158.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35215.1,
                                           SRR26643290.51896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000018.1  65218587-65218749
            164-255             JAXUCZ010000018.1  65219645-65219736
            256-328             JAXUCZ010000018.1  65221421-65221493
            329-390             JAXUCZ010000018.1  65334541-65334602
            391-487             JAXUCZ010000018.1  65337982-65338078
            488-549             JAXUCZ010000018.1  65391770-65391831
            550-679             JAXUCZ010000018.1  65437939-65438068
            680-729             JAXUCZ010000018.1  65438528-65438577
            730-835             JAXUCZ010000018.1  65507173-65507278
            836-966             JAXUCZ010000018.1  65511025-65511155
            967-1099            JAXUCZ010000018.1  65516916-65517048
            1100-1167           JAXUCZ010000018.1  65525175-65525242
            1168-1246           JAXUCZ010000018.1  65526319-65526397
            1247-1323           JAXUCZ010000018.1  65528841-65528917
            1324-1527           JAXUCZ010000018.1  65531547-65531750
            1528-1663           JAXUCZ010000018.1  65551334-65551469
            1664-1826           JAXUCZ010000018.1  65553405-65553567
            1827-2056           JAXUCZ010000018.1  65556812-65557041
            2057-2197           JAXUCZ010000018.1  65557878-65558018
            2198-7151           JAXUCZ010000018.1  65558233-65563186
FEATURES             Location/Qualifiers
     source          1..7151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..7151
                     /gene="Tcf4"
                     /note="transcription factor 4"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
     exon            1..163
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Tcf4"
                     /note="upstream in-frame stop codon"
     exon            164..255
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2193
                     /gene="Tcf4"
                     /note="isoform 21 is encoded by transcript variant 21;
                     ITF-2; SEF-2; RITF-2; SL3-3 enhancer factor 2;
                     immunoglobulin transcription factor 2; TCF-4; R8f
                     DNA-binding protein"
                     /codon_start=1
                     /product="transcription factor 4 isoform 21"
                     /protein_id="NP_001424026.1"
                     /db_xref="GeneID:84382"
                     /db_xref="RGD:69271"
                     /translation="MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGH
                     FTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQS
                     KTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPL
                     HSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQD
                     GHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLP
                     PMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDH
                     TNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLD
                     DAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVG
                     AHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGS
                     SEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKE
                     RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR
                     ERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM"
     misc_feature    586..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    586..>1071
                     /gene="Tcf4"
                     /note="RhoGEF, Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases [Signal transduction
                     mechanisms]; Region: ROM1; COG5422"
                     /db_xref="CDD:227709"
     misc_feature    1861..2115
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    1861..2115
                     /gene="Tcf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     Region: bHLH_E-protein_TCF4_E2-2; cd18945"
                     /db_xref="CDD:381515"
     misc_feature    order(1885..1887,1897..1899,1903..1911,1915..1917,
                     1930..1932,1993..1998)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1885..1887,1897..1899,1903..1911,1915..1917,
                     1930..1932,1993..1998)
                     /gene="Tcf4"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1924..1929,1936..1941,1945..1950,1957..1959,
                     1969..1971,1999..2001,2008..2010,2020..2022,2029..2031,
                     2038..2055)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     misc_feature    order(1924..1929,1936..1941,1945..1950,1957..1959,
                     1969..1971,1999..2001,2008..2010,2020..2022,2029..2031,
                     2038..2055)
                     /gene="Tcf4"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381515"
     exon            256..328
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..390
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..487
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..679
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..729
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..835
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1099
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1167
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1323
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1527
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1663
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1826
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2056
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2197
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..7151
                     /gene="Tcf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcgg atcggcggcg gcggcggcgg cggcggcggg gaagccggag cgggcgcggg
       61 cgccggccgt tggaggaggt ggtggtggcg gaggcagggg gatagacatg accgccgcct
      121 gggcgccggc gctgcaccgg gagcccctcg tcgcgcgcgg gcggtttgtg tgattttgct
      181 aaaatgcatc accaacagcg aatggctgcc ttagggacgg acaaagagct gagtgattta
      241 ctggatttca gtgcgatgtt ttcgcctcct gtaagcagtg ggaaaaatgg accaacttct
      301 ttggcgagtg gacattttac gggctcaaat gtagaagaca gaagtagctc agggtcctgg
      361 gggaatggag gtcatccaag cccgtccagg aactatggag atgggactcc ctatgaccac
      421 atgactagca gggatcttgg gtcacatgac aatctctctc caccttttgt caattccaga
      481 atacaaagta aaacagaaag gggttcatac tcatcttatg ggagagaaaa cgtacagggt
      541 tgccaccagc agagtctcct cggaggggac atggatatgg gcaacccagg aaccctttcg
      601 cccaccaaac ctggctccca gtactaccca tattccagca ataacgcccg acggaggcct
      661 cttcacagta gtaccatgga ggtgcagaca aagaaagtca gaaaagttcc tccaggcttg
      721 ccatcttcag tctacgctcc ttcagccagc actgccgact acaacaggga ctcaccaggc
      781 tattcttcct ccaagccagc agccagcact ttctccagct ccttcttcat gcaagatggc
      841 catcacagca gtgacccttg gagctcctcc agtggaatga atcagcccgg ctatggaggg
      901 atgctaggca actctcatat cccacagtct agcagctact gtagcctgca tccacatgaa
      961 cgtctgagct atccatcgca ctcctcggca gacatcaact ccagtcttcc tccgatgtcc
     1021 acgttccatc gaagtggcac aaaccattac agcacctctt cctgcacacc tcctgccaac
     1081 ggaacagaca gtataatggc aaacagagga actggggcag caggcagctc ccagactgga
     1141 gacgctctgg ggaaagccct ggcttcgatc tattctcctg atcacacgaa caacagcttc
     1201 tcctccaacc cttcaactcc tgttggctcc cctccttcac tctcagcagg cacagctgtt
     1261 tggtctcgaa acggaggaca ggcctcgtca tctcccaatt acgaaggacc cttgcactcc
     1321 ttgcagagcc gaattgaaga ccgtttagaa agactggacg acgcgattca tgttctccgg
     1381 aaccacgcgg tgggcccatc cacagctgtg cccggtggcc atggggacat gcatgggatc
     1441 atcggaccct ctcacaatgg agcaatgggc agtctgggct caggatatgg aactggcctt
     1501 ctctcagcca acagacattc actcatggtc ggggcccacc gtgaagatgg cgtggcactg
     1561 agaggcagcc attctctcct gccaaaccag gttccggttc cacagcttcc agtccagtct
     1621 gcaacttccc ctgacttgaa cccaccccaa gacccttaca gagggatgcc accaggcctc
     1681 cagggacaga gtgtgtcttc cggcagctct gagatcaagt ccgacgacga gggcgatgag
     1741 aacctacagg acacaaaatc ttccgaggac aagaaactag acgacgacaa gaaggatatc
     1801 aaatcaatta ctaggtcaag atctagcaat aacgatgatg aggacctgac cccggagcag
     1861 aaggccgagc gtgagaagga gcggaggatg gccaataacg cccgtgagcg cctgagggtc
     1921 cgtgatatca acgaggcttt caaggagctg ggccgcatgg tacagctcca cctgaagagc
     1981 gacaagcccc agaccaagct cctgattctc caccaggcag tggctgtcat cctcagcctg
     2041 gagcagcaag tgcgagaaag gaacctgaac ccaaaagctg cctgtctgaa aagaagggag
     2101 gaagagaagg tgtcctcaga gcctcccccg ctctccttgg ctggcccaca ccctgggatg
     2161 ggagacgcag cgaatcacat gggtcagatg tgaaagggtc caagttgcca ccttgcttca
     2221 ttaaaacaag agaccacttc cttaacagct gtattatcct aaacccacat aaacactgct
     2281 ccttaacccc gttttttttg taatataaga caagtctgag tagttatgaa tcgcagacgc
     2341 aagaggtttc agcattccca attatcaaaa aacagaaaaa caaacacaaa aaaaaaatga
     2401 atgaaagaaa gaaagaaaga gaaaatgcaa cttgagggac gacttcttta acatatcact
     2461 ctgaatgtgc gaagcggtat gtacaggctg agacgcagcc cagagactga atggcaatcc
     2521 ttccacactg tggagcaatg catttgtgcc taaacttctt ttggaaaaaa aaatataatt
     2581 aatttgtaag tctgaaaaaa aatatttaat ttaaaaaaaa ttgtaaactt gcaataatga
     2641 aaaagtgtac ttctgaagaa aaacgacatg aacgtttttg ttggtattca agtcagctag
     2701 tgtttctaat taccggatat tgaatagagg aagcccggct accctcataa caaaaccagc
     2761 aaccgtcctg atggcaaccg aaatgatgac attagccatt ccttagggta ggagggacag
     2821 atggatgtta tagacctatg acaaatatat atataaatat atatataaat atatattaaa
     2881 aatttagtga ctatggtaag cttttgttca tttgtttcag acttttttct cctgtaaaaa
     2941 aatagtactg attaactttt ttaaaagaaa gattttactg taaatatgga tttttttttg
     3001 tctgattttt gtcccttccc ccagtttgtt atcgtgacct gtagtgccaa ctctgcttcc
     3061 ggaggggcag tgcaggacga aatgctgacc ctgatgttgc ttctcattca taaatagtag
     3121 aaagttgttt ctccagtctt ttgggaacac aggacttaaa agtcacatca tgtgtagaaa
     3181 ttacatgcag cattgcccgg gcaaggcaaa aagagtttgt ctggcttgtg gcactgtgct
     3241 tgttaccctc tcctgggatt ttcagaggta cacggttaga atgctacaat gttaccactg
     3301 tgccttccaa tgtttatatc atcggaaaca tgacataatc aaagtggctg tgatttaaca
     3361 aaaaaaaaaa aagattcaag tgttacctac ctgtgtagcg gaagtagtgt gcagtgagac
     3421 gtttctgaat acatggtcag attttttttg gaaaaaatac aaaaacaaaa aaaaaaaaca
     3481 aaaaaattta aaaaaaaaag tcaagttcaa aaaccgtcaa atgagaaaat cgcaaggagt
     3541 gtgacagctg attgattttg ttgcttttct tgattttttt ttttttgttt ccaaatgggt
     3601 ttactaaaaa gtacatgact tacctgcctc ctccttcgtc tgaaaacaaa aaacaaaaaa
     3661 acaatgccaa cctatcccac agcattatag caagccttat aagccctaaa gcattaagtt
     3721 gcactttggt gaggaggggt agcgcagtat tctctctggc cagtatgagt gaagtttata
     3781 cttaacattt gatagaaaca tagatcaaac tgtggcacag taactcatca gatagctagc
     3841 gttgactctg ggcacaattg aaccaattcc catcctaaat ctttccaaca attgactttg
     3901 gtgtacagtg cagtgaacac atagaactcc tacttaagta ttcgtcagca tccttttgtc
     3961 tctaactcgg ttctgttttg acagccacac aatcttggca tgtattaagt aaaaaaaaaa
     4021 aaaaaatccc tgttgaagta gttttcccac ctatcagcac tgagtaattg ccgtaactca
     4081 atggaaatgg tctaaacgcc ccccatctct tgtcctgtac caccagttac acagtgacaa
     4141 aacacatctg taaattttat gcaaccaatg gcaaacctat cattattttg aaactgtgta
     4201 tgtaaaagtt atatttttac atgtagactc ttgttattat gtgttttaat acattgtatc
     4261 agttttttgt ttcctttttt ttttaactgt gtggttttaa aaagtcattt aaatgaaata
     4321 gcgagctaca agaatctgaa atttatgttc atttctgaaa atgtaagaac aaataagata
     4381 gttatcacgt ggtcaccttt tacaaaccca tcgatgtttt gactagctgt gtgtatgtgt
     4441 gtgtgtgcgc atgtgtgcgt gtgtgtgtat gtgtgttgaa aactgtaaat atgttcagta
     4501 gcgataaaac gacaatgctt tgatttgttg agaagttcct aaaatgtgga ggtggattga
     4561 aaatgtaggg gaatagcaga aatcagattt catgaagagc tcttctcttc gggggctttc
     4621 ctgtggaatg gtcaaacaga ggtgctccaa gaagggcaag gaagacagta acttcccctc
     4681 ctccctgaac gacggaaacc atgtgtacgt ggtctctcac catgttaaag attttctttc
     4741 cgtgatacat tctgcactct ttttgtatag tctaccaagg cgggtatccc tgggaacaat
     4801 attatgatat aggaagcagt atactctgat cacattcagg agaattgtat agaagagaat
     4861 atggtgttta ctctttaggg aactggaaat tctccctgca ttgatgtaca tcttcagagc
     4921 ggcccttttg atacacgtta tcataaaggt gctgactaaa gcagaattaa agtttttcaa
     4981 atctgtaaac aaagcaaaaa attaaattac agtcattcga ttgtttgttt tttttttttt
     5041 ccaattggtg cttttatatt ttgttctcac tcagacagaa aaggctgcaa tttcttgttc
     5101 accagctttg atgtattcat tactcggtaa tgtaatacgg ctattgtcaa attccttttg
     5161 gaaataagca aaaggcttcc ccaaggcctg cagcagctgc tggctacttt ctgcttggcg
     5221 cagaaacatg atctgaccct ctctgtagta atcgagttgt atctccagtt ttaaaaagaa
     5281 ggaaaaaggg aatgtggccg ttttaatgtg tttttttttt tcttttcttg ttgttatttt
     5341 gtaattctca aacccaggta agatattggt attcctgcac tggatttttg aaagaaactt
     5401 agcagaagac aggatcgaga tactatagaa gcatttccca agtgttcata ctatactaga
     5461 cataaatgat aacggcgatg tataggttca ggatcggttt aagagactca gactttgaaa
     5521 gcaacttgga acggttgatc cacctccaca ttcgagtaat taataattct gcagaattag
     5581 ggatctgtcc atctaggagt tgttacccat ttgtcttctg tgtggctgcg aggaacacta
     5641 acgcttttac aactgtcagt tcacccagtg gtacaactga ttctgactca gtcttccgat
     5701 tcctgttttg tattttgttt ttccactttt ttcctatctc ttgattttat tgttgttgtt
     5761 attgctattg ttattattat tattcgtgat ctttatttcg atgaggggtt gggaagtggg
     5821 agggagtcga actgagacta ggggttgaga ggattttttt ggtttggttt tcttttcttt
     5881 tttttttgtt tttttttttt tttgtttgtt tgtttcatct ttgcgtccaa caggcagaat
     5941 atggtctgtg tccaaaacgg aacttaagtc aggaaggaaa ccattcagcg taaacaagca
     6001 caacatgtag tctgtcggct gtctggaagc aaaaataaat taataaataa ataataaata
     6061 agtaaaagac acacacggag gtgaagatga aatgtgatgg attccgagac aatggggcac
     6121 caaggcctgt aggcctcctc ttgattttgc tttggttatg tttgttttcc ttagagatgt
     6181 ttttttcctc acgggacttg aagtgactca tctctgtgca gtaatggttt cgccatatgc
     6241 tcatttcaag tattatagac atatgtaatg gtgaaatata tgaactgtgg cctttttcat
     6301 tcttgttatt tgtgatgcaa ttaagtgaag agaagaaaaa aaaaagcaga gatttaccat
     6361 gtatcagtgc ctggcttttt gttataaagc ttcgtctgtc tagtgctctt tttgctataa
     6421 aaatagactg tagtacaccc tagtaggaaa aaaaaaccct aaatttaaaa ataaaaaaat
     6481 atatttggct tatttttcgc aggagcaatc cttttatacc atggatatta caaaaaaaaa
     6541 aattgtcaga ttctgaatat ttcttctttg tagatttttg gaatcattat aagtaaaagt
     6601 ttgttacttt attttactat ttaaaagatg ttattttgcc atgtgttact gagatgaaac
     6661 tgtatggtat agcttcttct gttcgttttt tgtttccggt tttttgtttg ttcgtttttg
     6721 gttttttttt tttttgtttg tttgttttgt tttgtttttt tttcttagtt gtaggtcgca
     6781 gtaaggactt ttccttttgt ttttgttttt tcgttatgtt ttgttttgtt tttgcgactg
     6841 tacacatagc tgcagcatta aaaactttta aaaaaatctg ttaaaaaaaa aagaaaaaaa
     6901 agggaaaacg tttaaaaaaa aaagataaac agttacacct tgttttcaac gtgtggctga
     6961 gtgcctcgat tttttcatgt ttttggtgta tttctgattt gtagaagtgt ccaaacaggt
     7021 tgtgtcctgg acttccttca agaggcgaac aacccagctt ggtctaggcc atgacctgtt
     7081 cccatctgta gttactcgat gaagtcatgt acatgaccgt tctgtagcaa taaatgtgcc
     7141 atttttataa a
//
LOCUS       NM_001437003            5924 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus fukutin (Fktn), transcript variant 1, mRNA.
ACCESSION   NM_001437003 XM_006238169
VERSION     NM_001437003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5924)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5924)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5924)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 5924)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 5924)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 5924)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 5924)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 5924)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 5924)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 5924)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006238169.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2476814.1,
                                           SRR26643295.21337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  73135386-73135548
            164-366             JAXUCZ010000005.1  73142997-73143199
            367-426             JAXUCZ010000005.1  73151592-73151651
            427-630             JAXUCZ010000005.1  73152711-73152914
            631-908             JAXUCZ010000005.1  73158194-73158471
            909-1041            JAXUCZ010000005.1  73160426-73160558
            1042-1171           JAXUCZ010000005.1  73165478-73165607
            1172-1305           JAXUCZ010000005.1  73169494-73169627
            1306-1433           JAXUCZ010000005.1  73170920-73171047
            1434-5924           JAXUCZ010000005.1  73187282-73191772
FEATURES             Location/Qualifiers
     source          1..5924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5924
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..163
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    70..72
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="upstream in-frame stop codon"
     exon            164..366
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1647
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="isoform a is encoded by transcript variant 1;
                     Fukuyama type congenital muscular dystrophy homolog;
                     Fukuyama type congenital muscular dystrophy (fukutin);
                     ribitol-5-phosphate transferase FKTN"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN isoform a"
                     /protein_id="NP_001423932.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    262..1095
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukutin N-terminal; Region: FKTN_N; pfam19737"
                     /db_xref="CDD:466166"
     misc_feature    1126..>1242
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     misc_feature    1126..>1242
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="LicD family; Region: LicD; cl01378"
                     /db_xref="CDD:470175"
     exon            367..426
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            427..630
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            631..908
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1041
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1171
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1305
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1433
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..5924
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttaggt aagatgaggg cctccgggct gtgtatctga gcctgggcgt gggcgggttc
       61 cctcaggcat gagtcgctgg tctactcgta ccctggccgg cggtccgcca ccctttgggt
      121 gcccgcccta cggcggcggg gaggagtccg acgtcggccg cagaagtacc tctgttgaca
      181 ggaaacaaga ttctgtttca taaagaagat gaaaacaact gggttcctgt taacaaacac
      241 ccaagagacc agcatagacc aatgagcaga gtcaataaga acgtggtctt ggcccttcta
      301 acactgatga gctgtgcctt cctgctgttt cagctgtact actacaagca ctacttgtca
      361 gcacggaatg gaacgggttc atcaaaatcc aaaggaaatc gagttggatt tgatagcaca
      421 caatggcgtg cagttaagaa atttattatg ctgacatcca gccaaaatgt gccggtgttc
      481 cttattgacc cttggattct ggaatcaatt aataaaaatt tcgaacaagt gaaaaatgcc
      541 tctcaaggct cggcctcaga atgcagattt ttctgtgttc cgagagactt cactgcgttc
      601 gcgctgcagt atcacctgtg gaagaatgag gatggatggt ttcagatggc tgagaacatg
      661 ggattccagt gcctgaagat tgaaagcaaa gatcctcggc tggatggaat agactcgctt
      721 tccggaactg agatccctct gcactatgtc tgtaagctgg ccactcacgc catccacttg
      781 gtcgtctttc acgagaggag tggcaactac ctctggcatg gtcacctacg actcaaaggg
      841 cacatggata ggaagtttgt tccttttcga aggctacaat ttggtcgtta tcctggagcc
      901 tttgacaggc cggagttaca gcaggttact gttgatggac tcgacatgct tattccaaaa
      961 gacccagggc gctttctaga agaagtacct cactccagat ttatcgagtg caggtataaa
     1021 gaagcccggg cattccttca gcagtacgtc gatgacaaca ctgtggatgc catggccttt
     1081 cggaagaggg caaaggagtt actgcaacta gcggccaaga cgctgaaggc gctgggagtg
     1141 cccttctggc tgagcagtgg gacgtgtcta ggatggtatc ggcaatgcag tatcattcct
     1201 tatagcaaag atgtcgacct aggaattttc attcaagatt acaaacctga tattgttttg
     1261 gcatttcagg atgcaggact tccactcaaa cacaagtttg ggaaggtgga ggacagcttg
     1321 gaactctcct tccagggaca agctgatgta aaacttgata tttttttctt ctatgaagag
     1381 actgaccata tgtggaatgg aggcacgcag gccagaacag gaaagaagtt taagtatctg
     1441 ttccccaagt ttacactgtg ctggacggag tttgtagaca taaaagtcca tgttccctgt
     1501 gaaacagttg actacattga agccaactat ggcaaggcct ggaagatccc tgtcaagacc
     1561 tgggactgga agagctcacc cccgaatgtg cagcccaatg gggtctggcc tatttcggag
     1621 tgggatgaag ttatccagtt gtactgagaa cactgagctc atgtgggacg tttcccagaa
     1681 agaaggtagg cagctgttga aagcactatg ttttctgcct gatgtgagag ccaaagagga
     1741 gaaatgacga gttggaagac agaaaaggtt ttctgactca tgggccatct aatcagttct
     1801 gccactcagc atttactgag gagtttatac accaggtgaa gtactaggat ctggtgaaca
     1861 ggcagagagg aatgagaggc cagcttctct cttgccctgt tggtaagcac tacaatttta
     1921 tgttaaggga aactaaccca ctctctgaag aggtgtacag tagaatgtat tccataatga
     1981 tttttaaaat gttaattaat gtttaaaccg gaaagtgagc tcatcagaca aagctaacaa
     2041 aggatgtgtt agttgagagt agttcatttc tgcctgccct cgggatttaa gctgctgtgt
     2101 tagtgttaag gttgtgggat atgagttaat attccagtga gtgattagac tttgtctcac
     2161 agagaaaaga cagtggccaa ctcattttac aagcagtgtg atacacagtt gacttcaagc
     2221 actgggcatt ctataaggga ggatgagagc cgatagcagc tcttgtcaag acgtacactg
     2281 ttttcatctt tgagatgaac atggatgctt agatggtgct tgaatccctg acatcataag
     2341 gatattttca ctgacctgca gtagtacttc ctgataaatc attcagtcgt gctatccaaa
     2401 agttgtgaca tctcaaagct tccgttcctt atttcattct tagtcactct taaactcaaa
     2461 aatggaagtt actcatgaat atttttatat tttatgaatg tataactttt ctgcctttaa
     2521 ttttaatatt gacactaagt aataatagac atacctctta attttttaaa aatacccttt
     2581 atttatttat caaccatagt tccatgtgtt taatttatgg cctacacact aatttattta
     2641 gcacaagata tgcctgttct tctatccaat attacttcac ggttccaaaa tgaagggtta
     2701 acgtgaacct ggccattact ccttttccca gattactgtc tttaaagcct gtgtccatct
     2761 ctagattttc attctgctga gtgtaatagg gcaagggctt cctacccaca agtactgcac
     2821 aagtgggacc cttgacctac actcctgagt ccattgtagt ggctgcacat aagccatgca
     2881 gtctcagaga gagatgacac agtgagtgcc tgcctgcctt gcctgggagg ggagggtcca
     2941 ctccctgctg cttagggatg tgcttcatgg caacctggca gatttccctt ggcacgtgta
     3001 gttactacag cagaaaccag gatagatgag agaatgggct ggcagaaaga aaagaaaaaa
     3061 gaaagaaaaa gaaaaacttg gaggaagtaa cttgaagcca cctatttcca aatttaaact
     3121 tcaacatgaa aactgtcttt gttggatgat atgcagcagt ctccatgcag cctccaagta
     3181 ggaatattgt ctctccataa gcatcatcta atcagagtgt tacagttatt agcacacatg
     3241 tacccaaatg acaaatcata atcagctctt tcctagaaaa taagtccata gaatacgtac
     3301 ccaagttgta gatacccaac cctacatatt tttctgtgtg cgcatgcgtg tgcacgcaca
     3361 cacccccact cgcacacacc agataatagt gtttttgagg acaaacccac cctacctgga
     3421 gaggatcatt tacttgtact caatatcaag aagtatgttt atatcgtgtt ccttgagagc
     3481 tcccaccttc tgccaggaga tcttacccac ccctgtttaa gtttcttctc tcatacctgt
     3541 cgttggagtg caaggtctgc cagtgtccat aatacaagct cttggtcctg ggcacagagg
     3601 ttctgtagtc ttcccttcat agaggatggg tacctgtttt ccctctggtt tggctttagg
     3661 ttttaggttc cgcccaccgt ggagaaattt tcccagaatt tgcaggtgag gtttacctct
     3721 aaaaatgact ccatgattca gtcatactga agtcagtgct tcttaactct tgaactctgc
     3781 tgagtgtccc gagatcttgg gtcaggtctg cccaccacct gaaccttttc agatcacttc
     3841 tcttccctcc ctgaatatgc taactgttat tctcctaata tgagtgcttt ctggtcccat
     3901 ttgcctggac tgcttgaaga tacctttaca ttaactcatt ggtagttctg ctgccgagga
     3961 tctttcagag ggaccctgag aagcagatgc tttctcggtt tacgacagcc atctacttcc
     4021 ctaagcgtgg aggacttgcc ccgctcttgg ttacagttac tgacattggc cactgagatg
     4081 aaataatagt aactaaaact ggcctccctg agagtacctg agatccgttc ttagtgtggc
     4141 ctccatgaca ctccagtgct tggtgagtcc tccagtgcct cagtgcctgc cattccccac
     4201 ggaaggcctg aggcgacaga aaatgctgag gagggatgtt tcctcttgtc cagaattctc
     4261 aggctaccgt ctcacctttg tctggggagg gttcaggagg tgggccaagg gaggggaagc
     4321 cttatctaca aaaaatagaa cagtttatgt ctgaagacat caccagaagt cagtttctga
     4381 ctcttgaaat gtttaaagga tttaatgatg catacagtgc ttccattcag gcccagcgtt
     4441 aagtaagtac tcgccatttc ctagttctcg gttcctttgt aacgtggaag gctgcacgac
     4501 agagttgctt agaactaaaa ttggggcact gctgagatgg cttagcaggc aaaagccctt
     4561 gtcaccaaaa gtgacatgag tttgattccc aggacccatg taatggaagg aaagaatctc
     4621 aaattgcttg tcatccaata cacagactct gatgtgcttg gagctcctct ctagcatgag
     4681 aggacaccac acacacacac acacacacac acacacacac acacacacac acacacacac
     4741 acacacacta agtaaatata atggaaagtt tttattttat ctaagcatta caggtcgaat
     4801 tatgtgattt ttgagtcatt gccatattcc ctccacctga aacagagctg gttctcactt
     4861 agttgaccaa gtggttgtct tctaatccta tcctattgta ctataccctt taagcacagt
     4921 cagattgctc ttaagttttg tgccttgatt ttcaatagtc cagctttggg cagctaacat
     4981 cactatatat aatgatttgg agaaccaaag attttggaat gcttagtttt atttacctgc
     5041 ctagtctgta tagaaatgtg ggctagttag tctaattgcc cagcatgtgt gaggtctgga
     5101 ttcagtacaa agcaccagaa gtctgagaca gaagacttag cacatgctga aggccagctt
     5161 gggctaccta gtgagtacca gcctatcctg ggctacagtg taagacccta tattgattga
     5221 ggacacagga gggaagagag aaacagagac agaatgagaa tatactcctg tcagccatct
     5281 gcccatagat gtatgtttta atctaagcga ggcaaaatca ggatatatag tgtggatttt
     5341 taaatagtta attgtagaca attaacagcc aattcgatat tgatgctttt tgtataggac
     5401 caataggcaa gtgtaatgtg ttgagaaacg tatttccaaa cactcagaac acctaggcta
     5461 aagcctgctc ctgtaactcc tggacctaac gtagaaggat cgaagaatct ctgtgaggga
     5521 gggcccatgt agtgacgcag acttccgtct acttatgagt aactttcgcg gaagggaaag
     5581 ctttgtcata taaagtattc tgtcaagcgc tttaagaatg ataagcctgt acaaacttat
     5641 gacaatgtgt tctaagcatg ggaaccagtt catgagtttg ttaaatgtag ttctgtcaac
     5701 atgggacata tgacgatgac atgtgtattg tatgtgaact ttctagacaa agttatgttt
     5761 taaacaagat aaaactggta tatgcttacc aggttaagat ttggttttgt cctcaggtat
     5821 agtttatggt actactgaaa tagttttaat gttattactc tgatctgaat ttgtaatata
     5881 tagtctactt tgggatgatt aataaaaatt tttaatctct tgtg
//
LOCUS       NM_001437063            7954 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 3-kinase,
            catalytic subunit type 2 beta (Pik3c2b), transcript variant 1,
            mRNA.
ACCESSION   NM_001437063 XM_006249754
VERSION     NM_001437063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7954)
  AUTHORS   Kozhevnikova,O.S., Telegina,D.V., Devyatkin,V.A. and Kolosova,N.G.
  TITLE     Involvement of the autophagic pathway in the progression of
            AMD-like retinopathy in senescence-accelerated OXYS rats
  JOURNAL   Biogerontology 19 (3-4), 223-235 (2018)
   PUBMED   29492791
  REMARK    GeneRIF: Missense single-nucleotide polymorphism in the Pik3c2b
            gene associated with autophagy regulation in in the progression of
            Age-related macular degeneration was found.
REFERENCE   2  (bases 1 to 7954)
  AUTHORS   Devereaux,K., Dall'Armi,C., Alcazar-Roman,A., Ogasawara,Y.,
            Zhou,X., Wang,F., Yamamoto,A., De Camilli,P. and Di Paolo,G.
  TITLE     Regulation of mammalian autophagy by class II and III PI 3-kinases
            through PI3P synthesis
  JOURNAL   PLoS One 8 (10), e76405 (2013)
   PUBMED   24098492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7954)
  AUTHORS   Das,M., Scappini,E., Martin,N.P., Wong,K.A., Dunn,S., Chen,Y.J.,
            Miller,S.L., Domin,J. and O'Bryan,J.P.
  TITLE     Regulation of neuron survival through an
            intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway
  JOURNAL   Mol Cell Biol 27 (22), 7906-7917 (2007)
   PUBMED   17875942
REFERENCE   4  (bases 1 to 7954)
  AUTHORS   Sindic,A., Crljen,V., Matkovic,K., Lukinovic-Skudar,V., Visnjic,D.
            and Banfic,H.
  TITLE     Activation of phosphoinositide 3-kinase C2 beta in the nuclear
            matrix during compensatory liver growth
  JOURNAL   Adv Enzyme Regul 46, 280-287 (2006)
   PUBMED   16857245
  REMARK    GeneRIF: Activated during compensatory liver growth, which clearly
            demonstrates that different class II PI3K enzymes have different
            subnuclear localization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006249754.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               JAXUCZ010000013.1  47047074-47047506
            434-1457            JAXUCZ010000013.1  47066101-47067124
            1458-1558           JAXUCZ010000013.1  47070150-47070250
            1559-1713           JAXUCZ010000013.1  47071019-47071173
            1714-1834           JAXUCZ010000013.1  47071452-47071572
            1835-1946           JAXUCZ010000013.1  47074701-47074812
            1947-2026           JAXUCZ010000013.1  47074965-47075044
            2027-2090           JAXUCZ010000013.1  47075674-47075737
            2091-2237           JAXUCZ010000013.1  47077131-47077277
            2238-2271           JAXUCZ010000013.1  47078024-47078057
            2272-2467           JAXUCZ010000013.1  47079705-47079900
            2468-2590           JAXUCZ010000013.1  47081111-47081233
            2591-2758           JAXUCZ010000013.1  47085022-47085189
            2759-2870           JAXUCZ010000013.1  47085718-47085829
            2871-3013           JAXUCZ010000013.1  47087142-47087284
            3014-3202           JAXUCZ010000013.1  47088397-47088585
            3203-3296           JAXUCZ010000013.1  47090048-47090141
            3297-3391           JAXUCZ010000013.1  47090263-47090357
            3392-3572           JAXUCZ010000013.1  47090764-47090944
            3573-3680           JAXUCZ010000013.1  47091658-47091765
            3681-3773           JAXUCZ010000013.1  47092398-47092490
            3774-3903           JAXUCZ010000013.1  47092799-47092928
            3904-4040           JAXUCZ010000013.1  47093850-47093986
            4041-4210           JAXUCZ010000013.1  47097827-47097996
            4211-4367           JAXUCZ010000013.1  47098327-47098483
            4368-4477           JAXUCZ010000013.1  47098812-47098921
            4478-4679           JAXUCZ010000013.1  47100258-47100459
            4680-4804           JAXUCZ010000013.1  47100850-47100974
            4805-4922           JAXUCZ010000013.1  47101747-47101864
            4923-5004           JAXUCZ010000013.1  47102626-47102707
            5005-5111           JAXUCZ010000013.1  47103003-47103109
            5112-5240           JAXUCZ010000013.1  47104171-47104299
            5241-7954           JAXUCZ010000013.1  47105020-47107733
FEATURES             Location/Qualifiers
     source          1..7954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..7954
                     /gene="Pik3c2b"
                     /note="phosphatidylinositol-4-phosphate 3-kinase,
                     catalytic subunit type 2 beta"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
     exon            1..433
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1457
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    486..488
                     /gene="Pik3c2b"
                     /note="upstream in-frame stop codon"
     CDS             528..5429
                     /gene="Pik3c2b"
                     /EC_number="2.7.1.154"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphoinositide-3-kinase, class 2, beta polypeptide;
                     nuclear cap binding protein subunit 2;
                     phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta isoform 1"
                     /protein_id="NP_001423992.1"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
                     /translation="MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK
                     EESRAKQNTEPSLISWDEPALDFYSKPAGRRTELKLLRGLSGSDPTLNYNSISPPEEL
                     PNSTSQDPQPGTDPWPKGSQSGDYLYIFDGSDGRCSLSPVSGDTDGSCKKLSPPPLPP
                     RVSIWDAPPLPPRKGSPSPSKISQPDDINSFSLVEQPSDKLLGAQDPGEGELPNGGGQ
                     RHVLGSVDYDGINDAITRLNLKSTYDSEILSDATRGWKEGRGPLDFSKDTSGKPVARS
                     KTMPPQVPPRTYTPRYANRKNATPGKNRRISAAPVSSRTHTVTNGHELFEVSEERDEE
                     VAAFCHMLDILRTGSDTQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTF
                     TCNCSSTVDLLIYQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCR
                     KFDINIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFD
                     TYHNEVDAFLLAEGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQP
                     KIQKDPSVLTVRENREKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEAC
                     HFSGALAFTVYGTHRIPIIWATSYEEFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHL
                     IIWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQKRVPEALGWVTTPLF
                     NFRQVLTCGRKLLGLWPATQENSSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPG
                     DKFSPRYEFGSLREEDQRKLKDITQKESLYWLSDADKKQLWEKRYYCHTEVSSLPLVL
                     ASAPSWEWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAEL
                     LDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQY
                     LLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILRAGLEEVRQFFA
                     LNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLR
                     QDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGV
                     TGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKT
                     TGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQ
                     AYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIE
                     SSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFAPRTHTLKSSGRIRDVFLCRHEKVF
                     HPSKGYIYVVKVMRENAHEATYIQRTFEEFQELHNKLRLLFPSSFLPSFPSRFVIGRS
                     RGEAVAERRKEELNGYIWHLIHAAPEVAECDLVYTFFHPLPRDEKTSGPSPAPKSSDG
                     TWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQPLQDGSDPDPYVKIYLLPDPQKA
                     TKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVHIRL
                     RELDLAQEKTGWFALGSRGHGTL"
     misc_feature    1614..1922
                     /gene="Pik3c2b"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1614..1922
                     /gene="Pik3c2b"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    2388..2906
                     /gene="Pik3c2b"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2A_PI3K_class_II; cd04012"
                     /db_xref="CDD:175979"
     misc_feature    2388..2906
                     /gene="Pik3c2b"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2A_PI3K_class_II; cd04012"
                     /db_xref="CDD:175979"
     misc_feature    2961..3467
                     /gene="Pik3c2b"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; Region: PI3Ka_II;
                     cd00869"
                     /db_xref="CDD:238441"
     misc_feature    2961..3467
                     /gene="Pik3c2b"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; Region: PI3Ka_II;
                     cd00869"
                     /db_xref="CDD:238441"
     misc_feature    3483..4544
                     /gene="Pik3c2b"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase beta; Region: PI3Kc_C2_beta; cd00895"
                     /db_xref="CDD:119421"
     misc_feature    3483..4544
                     /gene="Pik3c2b"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase beta; Region: PI3Kc_C2_beta; cd00895"
                     /db_xref="CDD:119421"
     misc_feature    order(3693..3695,3699..3707,3711..3713,3765..3767,
                     3771..3773,3780..3782,3873..3875,3909..3920,3933..3935,
                     3942..3944,4122..4124,4128..4130,4158..4163)
                     /gene="Pik3c2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119421"
     misc_feature    order(3693..3695,3699..3707,3711..3713,3765..3767,
                     3771..3773,3780..3782,3873..3875,3909..3920,3933..3935,
                     3942..3944,4122..4124,4128..4130,4158..4163)
                     /gene="Pik3c2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119421"
     misc_feature    4098..4124
                     /gene="Pik3c2b"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119421"
     misc_feature    4098..4124
                     /gene="Pik3c2b"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119421"
     misc_feature    4161..4235
                     /gene="Pik3c2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119421"
     misc_feature    4161..4235
                     /gene="Pik3c2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119421"
     misc_feature    4629..4955
                     /gene="Pik3c2b"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Beta Isoform of Class II Phosphoinositide
                     3-Kinases; Region: PX_PI3K_C2_beta; cd07290"
                     /db_xref="CDD:132823"
     misc_feature    4629..4955
                     /gene="Pik3c2b"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Beta Isoform of Class II Phosphoinositide
                     3-Kinases; Region: PX_PI3K_C2_beta; cd07290"
                     /db_xref="CDD:132823"
     misc_feature    order(4737..4745,4815..4820,4860..4862)
                     /gene="Pik3c2b"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132823"
     misc_feature    order(4737..4745,4815..4820,4860..4862)
                     /gene="Pik3c2b"
                     /note="phosphoinositide binding site [chemical binding];
                     other site"
                     /db_xref="CDD:132823"
     misc_feature    5037..5405
                     /gene="Pik3c2b"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2B_PI3K_class_II; cd08381"
                     /db_xref="CDD:176027"
     misc_feature    5037..5405
                     /gene="Pik3c2b"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2B_PI3K_class_II; cd08381"
                     /db_xref="CDD:176027"
     misc_feature    5187..5219
                     /gene="Pik3c2b"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     misc_feature    5187..5219
                     /gene="Pik3c2b"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     exon            1458..1558
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1713
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1834
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1946
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2026
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2090
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2237
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2271
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2467
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2590
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2758
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2870
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3013
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3202
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3296
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3391
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3572
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3680
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3773
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3903
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4040
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4210
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4367
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4477
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4679
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4804
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4805..4922
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..5004
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5111
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5112..5240
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..7954
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgcccc gccctctggc tcccgcgacc aggcgattcg gtgttgcggc tgctgccggc
       61 ggcctgggcc gcggtcctgg caggagccgg tgagcctcgc gcgccgtgca gtgcgctggc
      121 tgtccgggag atggcttctc cccgctcgcc cgccgctcgc gctattgtct cacccggggc
      181 tgcctgactg cgagctcgtg cacgctttca gcagacagca ccgggccccg gaccgtcccc
      241 cacgcccgtt gcttgcccgt gtggtcccct gcagcgggga tcccagagcc gcggtgcggg
      301 cgaagggagc aggcgacact gaacatcacg cgggggctgg agccgggagc ctccgagcga
      361 ggcgggtcgg cggagcacta gacacccagc cacgacagtc agggtgtcgc ggcagaaccc
      421 gcgaccagcg caggtcccga gacaacatgt acctgctgcc ctccatgccg gacgctggca
      481 ggaagtagaa ggcttcgtcg tcgtctcctg tgcccctcgc cctcatcatg tcttcgactc
      541 agggcaatgg ggagcactgg aaatccctgg agtcggtggg catcagccgc aaagagctgg
      601 ctatggctga agccctgcag atggagtatg atgctctttc ccggctccga catcacaagg
      661 aggagagcag ggccaagcaa aacacagagc cctctcttat cagctgggat gagccagcct
      721 tggacttcta cagcaagcca gcaggcaggc ggacagagct caagctcttg cgtggtcttt
      781 ctggctctga tcccacccta aattacaact ccatttcccc accagaagag ctccccaact
      841 ctacctccca ggacccacag cctggcacag atccctggcc caagggctcc caatctggag
      901 actatctcta tatttttgat ggctcagatg ggagatgctc tctgtctcca gtatcaggtg
      961 acaccgatgg ctcttgtaag aaactatccc cacctcctct ccctcctcgg gtctctatct
     1021 gggatgcccc tcccttgcct cctaggaagg gatctccctc accctccaag atctctcagc
     1081 ctgatgacat caacagtttc tctttggtgg aacagccatc tgacaaactg ctaggggccc
     1141 aggacccagg agagggagag ctacccaatg gtgggggaca gcgacatgtg ctggggtccg
     1201 tggactatga cggcatcaat gatgcaatca cgaggctcaa cttgaagtcc acttacgatt
     1261 cggagatatt gtctgacgct accaggggct ggaaggaggg ccgaggaccc ctggacttta
     1321 gcaaggacac ctctgggaaa cctgtagccc ggagcaagac gatgccccct caagtgcccc
     1381 ctcgaaccta tacgccccga tacgccaacc gaaaaaacgc aacacctggc aagaaccgcc
     1441 ggatatctgc cgctccggtg agctctcgga cccacactgt caccaatggc catgaattgt
     1501 ttgaggtctc agaggagaga gatgaggaag ttgctgcgtt ctgccacatg ctagatatcc
     1561 tgcgcacggg ctctgatacc caggactatt ccctaactgg gtgtgtctgg agcactgtca
     1621 ccccgagccc agagcacctt ggggatgagg tcaacctgaa ggtgactgtg ttgtgtgaca
     1681 gtcttcggga gccactcacc tttacctgca actgttcctc caccgtggac ttgctcattt
     1741 accagaccct ctgctacacc cacgacgagc tgagggaggt ggatgtgggc gactttgtgc
     1801 tcaagccctg tgggctggag gaattcctgc aaaataagca cgccttggga agccatgagt
     1861 atatccaaca ctgccgcaag tttgacatca acatccgact acagctgatg gagcagaagg
     1921 ctatccggag cgacctggcc cggacggtga atgatgacca gagcccttcc accttgaact
     1981 acctcatcca tcttcaagag cggccagtca agcagaccat cagcaggcag gccttgagtc
     2041 ttctgtttga cacttaccac aatgaggtgg atgccttcct actggctgaa ggggatttcc
     2101 cactgaaggc tgacagggtg gtccagtctg tgaaggccat ctgcaatgct ctggctgctg
     2161 tggagactcc tgagatcacg agtgctctca accagctgcc tccctgcccg tcacgaatgc
     2221 agccgaaaat ccagaaggat cccagtgtgt tgaccgtgag agaaaaccga gagaaggtgg
     2281 tagaagcctt gacagcagcc atcttggact tagtggagct gtactgcagc acattcaatg
     2341 cagacttcca gacagccgta cctgggagcc gaaagcatga tttggttcaa gaggcctgcc
     2401 acttctctgg ggccctggcc ttcactgtct atggcactca ccgtattccc atcatctggg
     2461 ctaccagcta tgaagagttc tacctctcct gctccctcag ccacggtggc aaggaacttt
     2521 gcagccctct gcagacccgg cgggctcact tctccaagta cctgttccac ctcatcatct
     2581 gggaccagca gatctgcttt cccgtgcagg tgaacaggct gcctcgggag accctgctgt
     2641 gtgccacact ctatgccctg cccattcccc ctcccgggag ttcctccgaa gccaataagc
     2701 agaagcgggt gcctgaagct ctgggttggg tcactacccc cctcttcaac ttcaggcaag
     2761 tcttgacctg tggccgaaag cttctgggct tgtggccagc aacacaggag aactccagtg
     2821 cccgttggag tgcaccaaat ttccaccagc cagacagtgt catcctgcag attgacttcc
     2881 ccacctcggc ctttgacatc aagttcacca gcccccctgg agacaagttc agcccccgct
     2941 atgagtttgg cagtctccgg gaggaggacc agcgcaaact taaagacatt acgcagaagg
     3001 agtcccttta ctggctctct gatgccgaca agaagcaact gtgggagaag cgctattact
     3061 gccacactga ggtgagctcg ctccccttgg tgctcgccag tgcacccagc tgggagtggg
     3121 cttgcctgcc ggacatctat gctctcctgc aacagtggac tcacatgaac caccaggatg
     3181 ccctgggact cctgcatgcc accttcccgg accaggaggt gcggcgcatg gccgtgcagt
     3241 ggatcggctc cctctcggat gctgagctgt tggactacct gccccagcta gtacaggccc
     3301 tgaagtacga gtgctacctg gatagcccct tggtgcgctt tctcctgaag cgagccatct
     3361 ccgacctgcg agtgacccac tactttttct ggttactgaa ggacagcctc aaggactccc
     3421 agttcagcat ccgttaccaa tacctgctag cggccctgct gtgctgctgt ggcaagggac
     3481 tgagggagga gtttaaccgc cagtgctggc ttgtcaatac cctggccaaa ctggcccagc
     3541 aggtccgaga ggccacccca tctgcacgcc agggcatcct tcgtgcgggc ttggaggagg
     3601 tgaggcagtt ctttgctctc aatggttcgt gccgtctgcc gcttagcccc agtctgctgg
     3661 tgaaaggcat tgtgcccagg gactgttcct atttcaactc caatgctgtc cccctcaagc
     3721 ttgccttcca aaatgtggat ccactgggcg agaatatcag agtcatcttc aagtgtggag
     3781 atgaccttcg ccaggacatg ctcaccctgc agatgattcg catcatgagc aagatctggg
     3841 tgcaggaggg gctggatatg cgcatggtca ttttccgctg cttctccact ggccgaggaa
     3901 aagggatggt ggagatgata cccaatgccg agacactgcg taagatccag gtggagcatg
     3961 gggtgaccgg ctccttcaag gaccgtcccc tggctgactg gcttcagaag cacaaccctg
     4021 gggaggatga atatgaaaag gctgtggaga acttcatcta ctcttgtgcc ggctgctgtg
     4081 tggctacata catcttgggc atctgtgaca gacacaatga caacatcatg ctgaagacca
     4141 cgggccacat gttccatata gacttcggcc gcttcctggg ccacgcgcag atgttcggta
     4201 atatcaagag ggaccgcgcc ccgtttgtct tcacctcaga catggcgtat gtcatcaacg
     4261 ggggtgacaa gccttccagc cgcttccatg attttgttga cctttgctgc caagcctaca
     4321 acctcattcg caagcacacc catctcttcc tcaacctcct gggcctgatg ttgtcctgtg
     4381 ggatccccga gctctcagac ctggaggacc tcaagtatgt gtatgatgcc ctgagacctc
     4441 aggacacgga ggccaatgcc actacctact tcacaaggtt gattgagtcc agcttgggca
     4501 gcgtagctac gaaactcaac tttttcatcc acaacctggc tcagatgaag ttcacaggct
     4561 cagacgaccg gctcaccctc tcctttgccc cccgaacaca tactctcaag agctctggcc
     4621 gcatccgtga tgtctttctc tgccgacatg agaaggtctt ccaccctagc aagggctata
     4681 tctatgtggt gaaggtgatg cgagagaacg ctcacgaggc aacctacatc cagaggacgt
     4741 tcgaggagtt ccaggaactg cacaataagc tgcgcctgct cttcccttcc tccttcctgc
     4801 ccagcttccc tagtcggttt gtgattggcc gctcccgggg agaggcagtg gctgagaggc
     4861 ggaaggagga gctaaatggc tacatctggc acttgattca tgcagcccct gaagtggctg
     4921 agtgtgacct ggtatatact ttcttccatc ctctgccccg cgatgagaag acttcaggcc
     4981 ctagcccagc cccgaagtca tcagatggga cgtgggcccg gccggttggg aaggtcggtg
     5041 gggaggtgaa gctgtccatt tcctacaaaa acaacaaact cttcatcatg gtgatgcata
     5101 ttcggggctt gcaaccgctc caggatggca gtgaccctga cccatatgta aagatttacc
     5161 tccttcctga ccctcagaaa gccacaaaga ggaaaaccaa agtagcccgg aaaacctgca
     5221 accctaccta caatgagatg ttggtgtatg atgggattcc caagggagac ctacaacagc
     5281 gggagctcca gttgagtgtg ctaagtgagc aaggattttg ggagaacgtg cttctcgggg
     5341 aggtgcacat ccgccttcgg gagctggacc tggcccagga gaagaccggc tggtttgcac
     5401 tgggatctcg aggtcatgga accttatgaa cccacttatg gcccagacct gtggcagctg
     5461 cccagagctg ggggagaagc ctctccctca cctaactcct ttgctaggaa ggggcagagc
     5521 tctcggtggc cttccccacg gtccaagtgg acctgacctg ggtgttgggg ctggaagagt
     5581 caagtgctgt ccgctgcccc ttccccccgc agacggcacc ggggttggct gtgacgaaca
     5641 gccccttgga agctgtgggc ttgcagccga gttttatgtt taccttgtgt caagggagca
     5701 atgcctgctc tggggtgtgt ggagtgcggg caatatgaag tagcacttag agagggaggg
     5761 tgggtggata ttttattttt atttttaaaa aatgaaatag taatgttgtc ctaactggga
     5821 caggaagctt tgtgtgagag gagcatgctg tgcctcagaa ggcaaaagag aaagactgat
     5881 tttttttttt tttttttttt ttttttgtat gatgaaagtt cttattggac tttttctcca
     5941 gggttttggg ggttttcttt tctagctata ggaaatattg gggagggccc tggtgggtcc
     6001 tcggtgaagc cctccctctc tcaggcagac tggggaggag tagggaggac taaccgactg
     6061 ccggactgac gctcactctg ggccatccga ttttgcctcc aaaggagtgc atcgtgataa
     6121 ctacgtgtgt aaggaagggc cttccatagt agggttccgc caaggaccta tattcaggga
     6181 cccatgctct ttagggcaaa ggatttcctc ctctcttccc ctgctgcttg gactctgtgc
     6241 gagcaccttc ctttcccctt ccccactctg ttctctcagc cctctgtggg tcacccagtc
     6301 ctggtgacta cactggggtg cttctatgcc ccatcttgtt cgatgggaca aaatgctgcc
     6361 aacccttagc tcggggccat gcctatagag gcaccgtgcc atttgctgca gtttctggga
     6421 actgtccccc gagacggtct actactttct cttccaaacc ctgtttctgt cacactttaa
     6481 aaagaacttc attggttctt tttttttttt ttgagctggg gaccgaaccc agggccttgc
     6541 gcttcctagg caagcgctct accactgagc taaatcccca aacccaagaa cttcattctt
     6601 tagggccatg aagctgttga gggtgtagac aaagaggtgc tcagtccata gctgcaaaga
     6661 gtgagcattg gtcaatgcaa tcatttcttc tggttagttt cctggccaga aggaagctgg
     6721 attagagcat cttcctcttt ggaaaacaag caaaagatta tttcaacccc ttccttcctt
     6781 ccttccttcc ttccttcctt ccttccttcc ttcctttttt tttttttctt tttcaagaca
     6841 gggtttttct gtggagccct ggctgccttg gaacaggcag agatccaact gcctctgcct
     6901 cccaagtgct gagattaaag gcgtttgcag ccaccacctc ctggctcaca cagctttctt
     6961 acgagctact aggggccaaa cccagggccc tttgagtact gcaccaccaa gctgtgtctc
     7021 cagcccacct tgcagtcttt gtttctcacc agatgaattt aaaatccact ctcgagtttc
     7081 caaagagttg tctcatttta aaggtgacag gtaggactca atttaacttt ttgtattttt
     7141 taagacaggg tctcactatg taccataggc tggccttgaa ctcacagaga tctgtctgcc
     7201 tctgcctctg cacgggaact aacttttaaa agaagagtta gcaaggacac gacagtttct
     7261 ctgtgacccc attactggag agagaaaaag ttccatggaa gcttacatgg aaacaagaaa
     7321 ctttttttgt tttgctgttg tttattttgc ttgtttttgt ttatgagagg ggatatcatg
     7381 tagcccaggt tggcttcaaa ctcctatgta gatgaggatg accctgagct cctgatctac
     7441 ttgcctttcc aactcgcagg tgctaagatt acaggcatga gctgcccctt ccattttttt
     7501 cttaatttaa aatggcgggc ctgtgaggtg gctcagtgag taaggggact tgctctgtca
     7561 acttaagttt gatcactgag accttcgaga tggcgggaga cgaccaactc ctacaagttg
     7621 ttttctgtcc tctgtatgca ctacacaaca tgtgtgcaca tacacacaca cacacacaca
     7681 cacacacaca cacacacaca cacacacaca gataacataa ttttaaaatg ccaagaataa
     7741 agcagcctgc tgaaggcagg agaccagagc agaaccttcc agatatttgg accatagacg
     7801 agcttctggc tttttgcctg cagctcattt tattttgacc ctttatgtcc ccgacttaaa
     7861 gaggtctgtg tactgtaccc acttcccatg ctcctttatc ttctactttc tctggaattg
     7921 tattttttaa ataaacgaca tttgagaaaa caaa
//
LOCUS       NM_001437046            1346 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor COX18
            (Cox18), transcript variant 2, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001437046 XM_006250771
VERSION     NM_001437046.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Bourens,M. and Barrientos,A.
  TITLE     Human mitochondrial cytochrome c oxidase assembly factor COX18 acts
            transiently as a membrane insertase within the subunit 2 maturation
            module
  JOURNAL   J Biol Chem 292 (19), 7774-7783 (2017)
   PUBMED   28330871
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Gaisne,M. and Bonnefoy,N.
  TITLE     The COX18 gene, involved in mitochondrial biogenesis, is
            functionally conserved and tightly regulated in humans and fission
            yeast
  JOURNAL   FEMS Yeast Res 6 (6), 869-882 (2006)
   PUBMED   16911509
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Sacconi,S., Trevisson,E., Pistollato,F., Baldoin,M.C.,
            Rezzonico,R., Bourget,I., Desnuelle,C., Tenconi,R., Basso,G.,
            DiMauro,S. and Salviati,L.
  TITLE     hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase
            assembly
  JOURNAL   Biochem Biophys Res Commun 337 (3), 832-839 (2005)
   PUBMED   16212937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006250771.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.83180.1,
                                           SRR26643297.43059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000014.1  18149994-18150384
            392-492             JAXUCZ010000014.1  18151605-18151705
            493-656             JAXUCZ010000014.1  18155050-18155213
            657-781             JAXUCZ010000014.1  18155531-18155655
            782-889             JAXUCZ010000014.1  18158802-18158909
            890-1346            JAXUCZ010000014.1  18161166-18161622
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1346
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="cytochrome c oxidase assembly factor COX18"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
     exon            1..391
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="upstream in-frame stop codon"
     CDS             68..1066
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mitochondrial inner membrane protein COX18; COX18
                     cytochrome c oxidase assembly homolog; cytochrome c
                     oxidase assembly homolog 18; cytochrome c oxidase assembly
                     protein 18; COX18, cytochrome c oxidase assembly factor"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein COX18
                     isoform 2"
                     /protein_id="NP_001423975.1"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
                     /translation="MLCGSCAGLLRSLRTLQLRAPGSLPAWSSARLPTLPVWAAASVS
                     AASPGGWYEALAASAPVHAAEEMLLSAQETTGLPWWGNILLSTVVLRGAVTLPLAAYQ
                     HYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNIRRLVSELYVRD
                     NCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDAGISVQDQLAAGGTLWFPDLTA
                     VDSTWILPVSVGVVNLLIVEIFALQKIGKSRFQMYVTNFVRAVSVLMVPVAATVPSAL
                     VLYWLCSSLMGLSQNLLLRSPGFRQLCRIPPSRSDSETPYRDLSAAFCAKFLSRKR"
     misc_feature    293..958
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="Five transmembrane core domain of mitochondrial
                     inner membrane protein Oxa1 and similar proteins; Region:
                     5TM_Oxa1-like; cd20069"
                     /db_xref="CDD:410993"
     misc_feature    293..958
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="Five transmembrane core domain of mitochondrial
                     inner membrane protein Oxa1 and similar proteins; Region:
                     5TM_Oxa1-like; cd20069"
                     /db_xref="CDD:410993"
     exon            392..492
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            493..656
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            657..781
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            782..889
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1346
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagcctc ctgatggcca aggtctaggt gtcttcctcg ctgacctgcc gcccgtcgtg
       61 tctagccatg ctatgcggat cgtgtgccgg gttgctccgg tcgctgcgca ccttgcagct
      121 ccgggcaccg ggatcactgc ccgcctggag cagcgcgcgg ctcccaaccc ttccggtatg
      181 ggcggccgcg tcggtttcgg cggcctctcc gggtggctgg tatgaggccc tggcagcgtc
      241 ggcgcccgtg catgcggcgg aggaaatgct gctgagcgcg caggagacca caggcctccc
      301 ttggtggggt aacatcttac tcagcaccgt tgtcctgcgt ggtgctgtca ctctgcccct
      361 ggccgcctat caacattaca tccttgctaa ggtggaaaac ttgcaaccag aaataaaaga
      421 catcgccaag cgccttaacc aagaagttgc agtctgtgca cgtcagtttg gttggtccaa
      481 gagagtggcc agactcactt acctgaagaa cattcgcaga cttgtgtcgg agctgtacgt
      541 tcgtgacaac tgccatcctt tcaaagccac ggtcctagtc tgggtccagc ttccaatgtg
      601 ggtcttcata tccgtcgccc tccggaacct tagcacaggg gccacacatt cagacgcagg
      661 catttctgtt caggaccagt tagctgccgg cgggaccctg tggtttcctg acctcactgc
      721 agtggattcc acctggattc tgcctgtctc tgttggtgtt gtcaacttac tgatagtgga
      781 gatttttgct cttcaaaaaa tcgggaagtc acgttttcaa atgtatgtta cgaattttgt
      841 tcgagccgtc tcggtgttga tggtcccagt ggctgccaca gtaccctcgg cgcttgttct
      901 ctactggctg tgctccagcc tcatgggcct ctctcagaac cttctgctgc gctcccctgg
      961 cttccgacag ctgtgccgga taccaccaag caggtcagac tcggagaccc cgtacagaga
     1021 cctctctgct gccttttgcg ccaagttcct ttcaagaaaa cgatgagttc gctcccagtt
     1081 ccgtgaaaaa attacagatg tcactgtcag cttcatgcac tgaattttga agcttttatt
     1141 taaatatcat gaagcacagt gggaaagatg taatttggat gtatttgaca tttagtatta
     1201 aaaactaaat gttcagttgt aagagtgtaa aaataagaca ggatgcctgg ccttgttcat
     1261 aaaaatcata gttttgctga gaacaggatt agatcctgtg taatctctgt gcccaactgt
     1321 ccacaaataa aggtttataa attaaa
//
LOCUS       NM_001436983            4158 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 4 (Dcun1d4), transcript variant 2, mRNA.
ACCESSION   NM_001436983 XM_017599288
VERSION     NM_001436983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_017599288.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1990344.1,
                                           SRR26360181.458866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000014.1  35087100-35087168   c
            70-130              JAXUCZ010000014.1  35086926-35086986   c
            131-201             JAXUCZ010000014.1  35057754-35057824   c
            202-241             JAXUCZ010000014.1  35057543-35057582   c
            242-356             JAXUCZ010000014.1  35049628-35049742   c
            357-448             JAXUCZ010000014.1  35047027-35047118   c
            449-519             JAXUCZ010000014.1  35037634-35037704   c
            520-611             JAXUCZ010000014.1  35034530-35034621   c
            612-720             JAXUCZ010000014.1  35024657-35024765   c
            721-825             JAXUCZ010000014.1  35012393-35012497   c
            826-928             JAXUCZ010000014.1  35010391-35010493   c
            929-4158            JAXUCZ010000014.1  35006799-35010028   c
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4158
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="defective in cullin neddylation 1 domain containing
                     4"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
     exon            1..69
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    31..33
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="upstream in-frame stop codon"
     CDS             64..984
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DCN1-like protein 4; DCN1, defective in cullin neddylation
                     1, domain containing 4"
                     /codon_start=1
                     /product="DCN1-like protein 4 isoform 2"
                     /protein_id="NP_001423912.1"
                     /db_xref="GeneID:360928"
                     /db_xref="RGD:1310422"
                     /translation="MEFTQEHQACHPQGSEEMKHWKDFQLNSHLSTLANIHKIYHTLN
                     KLNLTEDVGQDDHQTGSLRSCSSSDCFSKVMPPRKKRRPASGDDLSAKKSRHDSMYRK
                     YESTRIKTEEEAFSSKRCLEWFYEYAGTEDAVGPEGMEKFCEDIGVEPENVVMLVLAW
                     KLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRTTLDYLRSLLNDTTNFKLIYRYAFDFA
                     REKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLEQSKYKVINKDQWCNVLEFSRTI
                     SLDLSNYDEDGAWPVLLDEFVEWYKDKQMS"
     misc_feature    628..960
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    628..960
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     exon            70..130
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            131..201
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            202..241
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            242..356
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            357..448
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            449..519
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            520..611
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            612..720
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            721..825
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            826..928
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
     exon            929..4158
                     /gene="Dcun1d4"
                     /gene_synonym="RGD1310422"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttagag aagacctgtg gataaagcca tgacagtggg cagccttggc caagcaaggc
       61 ttaatggagt ttacccaaga acatcaagcc tgtcatccac aagggtctga ggaaatgaaa
      121 cattggaaag actttcagct gaactctcat ctctcaacac tggcaaacat tcataagatc
      181 taccacaccc ttaacaagct aaatctgaca gaagacgttg gccaagacga tcaccaaaca
      241 ggaagcctgc ggtcttgcag ttcttcggac tgctttagca aagtgatgcc gcccaggaaa
      301 aagagaagac ctgcctctgg agacgactta tctgccaaaa aaagcaggca tgacagcatg
      361 tataggaaat acgagtcaac tagaataaag actgaagaag aggccttctc cagtaagcgg
      421 tgcctggagt ggttttatga atatgcagga actgaggatg cggtgggtcc tgaaggcatg
      481 gagaagttct gtgaagacat tggtgttgag ccagagaacg tggttatgct tgtcctagct
      541 tggaaattgg atgcacaaaa catgggctat tttactctgc aggaatggct gaaaggaatg
      601 acttccctac aatgtgatac aacagaaaaa ctcagaacta ctttggatta cttaagatca
      661 ttattaaacg atacaacaaa ctttaagctc atttacagat acgcgtttga ctttgcacgg
      721 gaaaaggacc agcgcagcct agacataaac actgccaagt gcatgttggg actgttatta
      781 ggaaaaatct ggcccctttt tccagttttt caccaattct tagagcaatc gaaatataaa
      841 gtgataaaca aagaccagtg gtgcaatgtg ctggagttca gcaggacaat aagtctcgac
      901 ctcagcaact acgatgaaga cggagcatgg ccagttttgt tggacgaatt tgtggaatgg
      961 tataaagaca agcagatgtc ctaggacctt atgcatagca gcgcgagagt cactgttacc
     1021 acggtcatgt cacccattag ccataaactg ctgtttgtat cgaagcgcat gctgcttttc
     1081 ttgcactgtc tgcctctcgc aggggtgttt ggtgtttgct attggatggg ccgctctgct
     1141 tgatgtgtag cattgttctc ttggaggctg ctctgcagtc cattttcaca ctacagattg
     1201 gtgaattgcc aacgtcctca ctgtgattat gtgtatattg ctgtttaaat ttgtatatgt
     1261 gtataaaatg aaaagcttca cctagagatt atttctgcaa aaatgtattg taaaaataat
     1321 tttgtggcat atttttagtc cccccctttt tttttcaaat gaaccagtta tactttattt
     1381 ggtctcaaat gtagcatttc agaaaacatt acaactgtcc ccataagcaa gtattgccag
     1441 aatcaacctc actgcttaag aggccaactt ctggaagaag taggagccgt gactttctgt
     1501 ggcataagct aaatatgact tggttccctt ggcaactttg atattttaaa gtgacaaaag
     1561 ttataattta tttgagcgca cagacatatg acatgctaca aagcatttct aacacaaaaa
     1621 gtacaggttt atgggggttt ttccttcctc ctcctcttcc tcctccttaa gttgctcctc
     1681 atttaaattg aaaattaagt ttccatcaat ctttcactgt ttcccgcttt gtgttcctct
     1741 agcagtgttt ggtcagctga agctctctgt gccactgtga gtaaaatgtc ccatgagcct
     1801 cctggtttgc tggcggcata agcactttga actatggctt gagactttag ttcttcttgt
     1861 atggcgtctg tagcccacga gggttttgga gttttttggt ttgtttgttg ttgttgttgt
     1921 tgttgttgtt ttaaaccaca agtgagaagt gtttgttttc tgtctgtttc ttctgtgctg
     1981 ggcttttcct ggcaacacgt ccattgcagg cagtggactt gaaaccacca gcattgagct
     2041 aaccctgttc atattgggac ctttctcaga ggggccactt gtcattcccg gagtcacatg
     2101 tacagagggt ggtagccatt atgtggatga gaaaccagag ccaacacagt ggtagttgtg
     2161 catttgtacc ttacgtctta tttttagggt ttgtacttgc tcgccttgcc cctcttgcag
     2221 aagcttacag ttacaagttt ttccaactat ttggtgctat gactcactca gtccctgaag
     2281 tttgtgaaca cgtctgagat ttaacccagt aaagagccat ggcttgtttg ctgggtaaac
     2341 ggtgtagtgg gataagatcc gtgcctgccc aggctgctga tgactggagg atattgggat
     2401 tatctgccaa aaagaaaaaa aaatgtcctc tacattaaat gtgaaccttt aaatggcatt
     2461 aaatgatcag agcacacaga caatgctacc ccgaccaccg tcctatagtt ccttttcaga
     2521 gtgttgctat tttcatattt ctttccctga ttgaaccacc aaagacagaa atgtttatgt
     2581 atgtaccgtg tgcgtgcata tgcaaaatca tggtgtgata gaatgtttat gtatataccg
     2641 tgtgcgtgca tatgcagaat catggtgtgg tagaaggcaa atacttgcct tttcccacca
     2701 aataatgcga tttggtttgc tgtgaaaaat aaatcagaag tttgaaaaac caacaaaaca
     2761 agccaacgtt tcttcagcat agttaatcat cctttgtccg cagtctcaca gatttgtatc
     2821 tgaacacaat gtagacttct tggaaaacca cagctgttga gactgctctg tgaaaggcat
     2881 tccagtgcat atgggtgtgt gacagtgggg actgctaaag acaggcacgg ctctgtggag
     2941 aagggttcct tgtcgggtgt cccaaggtta cagaatcatt ctctcagggc gctgttctgg
     3001 aggtagatca actgttgatc gcctcattgc aaggatggac cgtagatggg attgttttaa
     3061 acgctgtgtg ggaatggaga gaatgtttta aacactaagc acagtggatc tgtgaataaa
     3121 gggttgttac cagggtgaga aattccattt catctacagt gagcattttg gtaatagtga
     3181 ctcaagtaag aaccaccatg atgtatacgg tatggaagtt cgaattctgg aggggataac
     3241 caatatttag aactccagat aatgtctgga ctgcctgaag aaacaaacca ctgtgacgtg
     3301 gcttgccttt ggatttctcg attttacaga gctattttta agggagtcag acacagtaat
     3361 aagacacctt ttcttgaaga atcgccaagt tacgcaagtt gaacgatcac caagagcact
     3421 tatggccagc gtaggaagaa gccagggcgc cttcggttct ccagtacctg agctccagcc
     3481 acccttcctc ccttcacctg tgtttcaggg cgctgcgact cgtcttgttg gggtacgcga
     3541 cttgtagaca tttccactgc actaggtaga agttacgtgg caagatttgc tggataccca
     3601 ttgtagcctt aggtgcgcct cttttgaagc ctgaactctt gagttcagta ttgatatctg
     3661 attagacaaa cctctagatt ctggtttaac agatttctgt tgcctctaag tctccatcct
     3721 aaccatactt ttgaagttta tacagaaagc tttaagagtt tagtttgtgt ccttggtttt
     3781 tatttttaca actgctaaaa tacctctgta agccttatcc tttattcttt catagttgta
     3841 taaaattgta tagaattcat tgaccaactg aaatgttggg tatctgtaaa tgagaccaaa
     3901 atgtggttgc ttttttccat aaactgattt ccattgggcg ctgctgtgat gtgagcagca
     3961 gccagcctgt gactgtgaat gcctcgtgtc gtcagtattt gcattacatt catacaagtg
     4021 tgcaagtcct gtgactccca gcttaactaa aatactgtca tgccatttaa tgagcacaga
     4081 aaactggttt aggttttaat ggagttgatg taaaatgata gcccataaat aaacagatat
     4141 ttgtgtttgg tttccgaa
//
LOCUS       NM_020303               2534 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 4, mRNA.
ACCESSION   NM_020303 XM_344538
VERSION     NM_020303.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced NM_020303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091169.1, SRR26643293.75524.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000016.1  73925752-73925871
            121-200             JAXUCZ010000016.1  73926790-73926869
            201-256             JAXUCZ010000016.1  73927485-73927540
            257-360             JAXUCZ010000016.1  73929752-73929855
            361-437             JAXUCZ010000016.1  73930126-73930202
            438-615             JAXUCZ010000016.1  73931687-73931864
            616-681             JAXUCZ010000016.1  73932826-73932891
            682-753             JAXUCZ010000016.1  73934031-73934102
            754-911             JAXUCZ010000016.1  73934279-73934436
            912-993             JAXUCZ010000016.1  73935273-73935354
            994-1130            JAXUCZ010000016.1  73939574-73939710
            1131-1320           JAXUCZ010000016.1  73941664-73941853
            1321-1416           JAXUCZ010000016.1  73946164-73946259
            1417-1612           JAXUCZ010000016.1  73947426-73947621
            1613-1703           JAXUCZ010000016.1  73957828-73957918
            1704-1920           JAXUCZ010000016.1  73958685-73958901
            1921-2007           JAXUCZ010000016.1  73973622-73973708
            2008-2122           JAXUCZ010000016.1  73974416-73974530
            2123-2285           JAXUCZ010000016.1  73981312-73981474
            2286-2339           JAXUCZ010000016.1  73983410-73983463
            2340-2534           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2534
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            121..200
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            201..256
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    220..222
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="upstream in-frame stop codon"
     CDS             223..2352
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 3 is encoded by transcript variant 4; a
                     disintegrin and metalloprotease domain (ADAM) 5; tMDC II;
                     a disintegrin and metalloprotease domain 5; disintegrin
                     and metalloproteinase domain-containing protein 5;
                     transmembrane metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein II; a disintegrin and
                     metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 3"
                     /protein_id="NP_064699.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MKTPISSILKSNGLGIFLYRSFITSTAVSYTYDRQDVRHSQSLS
                     SLKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTN
                     QQAKIPDLGENQTYSWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSD
                     TRVVLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKH
                     KYRPQHISYLLAFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLS
                     IGIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLP
                     MERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGEC
                     CGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLC
                     MTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFK
                     RLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDM
                     FCLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSI
                     DDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRE
                     RSEGTSCITEDSVSNTKMTTNEGSTLH"
     misc_feature    <280..516
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    <280..516
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     mat_peptide     517..2349
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /product="Disintegrin and metalloproteinase
                     domain-containing protein 5. /id=PRO_0000349303"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BK84.1)"
     misc_feature    643..1224
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    643..1224
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1285..1509
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1285..1509
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1519..1950
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1519..1950
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    2170..2232
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BK84.1);
                     transmembrane region"
     misc_feature    2290..2349
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BK84.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            257..360
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            361..437
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            438..615
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            616..681
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            682..753
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            754..911
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            912..993
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1130
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1320
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1416
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1612
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1703
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1920
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2007
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2122
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2285
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2339
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2534
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgccctc cccacctgcc tggccagatg ctcctcagct aagctccagg accaccaagg
       61 gagccatgtt cctccttctt ttgctggttg tgcatcttaa tgggctgcag gcaggccaac
      121 atcctcagaa aaccatcctg caaacaactg ttcctgaaaa gatctcatca ccagatgtgg
      181 aaacagatcc agaaaaccat atggcttatc ttattacaat aaatgaaaac ccccatttca
      241 tccatcttaa aaagcaatgg tttggggatc tttttgtata gatcgtttat aacttcaact
      301 gcagtgagtt atacatatga cagacaagat gttcggcatt ctcagtcttt gtcatctctg
      361 aaaaattgca attacaacgg atacgttgca ggttttccaa attctatcgt gtcgctcacc
      421 gtttgctcag gactcagggg aatgatacaa tttgaaaatg tctcctatgg aatcgaacct
      481 gtggaaaccc tgtcaggatt tatacacgtg atctatgaga acacaaatca gcaagctaag
      541 attcctgact taggagagaa tcagacgtac agttggtctg atgaattaga ttatcaattc
      601 cgaagcaaca tgaagaaatc cggatttgcc gtgttacggc cacggtacat taagacggat
      661 atcgtcgtgg ataaaaagct gtttgattac atgggctccg acactagggt cgtgctacag
      721 aaagtcattc agatcatcgg tttcattaac actatgttct ccaagttgaa actgacggtt
      781 ttaataaatt ccgttgaaat ctggtcgaag gaaaacagaa ttgatttccc agaggcacct
      841 gaaaacttac tggtccagtt tttacattgg aaacataagt atagaccgca gcacatttca
      901 tacttactgg catttgtgga gcatcctgct tccacgggag ccctctatcc ggggaatctg
      961 tgcaaaccga tctatggtgc tgccattgcc ctgtacccta aaggtttgtc actagagtcc
     1021 tacagcgtca tcgtcctaca actactgagc atcggtatag gcttaaccta tgacaacgct
     1081 gacagctgcc actgtacagg agacgtctgc ctgatgacgc ccaaggcaat atattctggg
     1141 ggtgtgaagg acttcagtac ttgtagcttg gatgacttca aatacctgtc aacacaagac
     1201 cttgaatgtc tccaggactt gcctatggaa agacaaaaga agaagccttc caggccaagg
     1261 agaatctgtg gcaacgggat attggaaatg aacgagcagt gtgactgtgg cactttgaag
     1321 aattgtacac acaaaaaatg ctgtgacccc atgtcgtgcc gactgaagtc caaagccgtg
     1381 tgtggctccg gggagtgctg tggtcaggac tgcaaggtaa aaccggttaa tgtactctgt
     1441 agaaagtcga agaatgaatg tgactttgag gagtactgta acggaaatga cgcttactgt
     1501 gtccctgaca cgttcgcacg caacgggcag tactgcgact cagggcaagc cttctgctac
     1561 agtggtcttt gtatgacgag taataatcaa tgcatgaact tgctcgggaa atatgtgaga
     1621 ggagcttcct tcgcatgcta tgaagagttc aattccagaa acgatagatt tggcaactgt
     1681 attagaaagt tttgtagttt cgaaaattct ctctgtggga agttggtctg tacctggcca
     1741 ttcaagaggc tgctcatgaa agacaatatg tctgcggctt atggacaaat ccgagacgat
     1801 ttatgcatct ctctgtataa aggagggagg ccacttaaga caacattgtc aacatattcc
     1861 gatatgtcag aaagagacga aacatttgta aaagacggca caatctgtgg tcctgatatg
     1921 ttttgtttgg aaacacagtg caaagaaacg agatttttgg tggattttca acagtgcaat
     1981 acttcccgag attgcaatga ccatggggtt tgcaacaact ttaatcattg tcattgtgat
     2041 aaaggatata accctcccta ttgtgagtca gtaaaaggac agtttggaag cattgatgac
     2101 ggccacaaat attacattga cgaagggaaa agcgctaagc agcagaatcg tggtattcac
     2161 ccaaagcagc aactccagct tattctgtat ataacgctgc ccttgattat gattatctcg
     2221 gctgtattta taaagcaaag caaactgagt cggctatgcg gcagagaaag aagcgaaggc
     2281 accagctgta taacagaaga cagtgtgagt aacaccaaga tgaccaccaa cgaaggaagc
     2341 acccttcact aaccacctca agtgttgcca cccaaaaaga agatagtctg gattaaccac
     2401 gggaaactgg cattttgagc aagaggaagg ggaaaaaacc acccccaaac caacccacag
     2461 cttctctccc acttctgcag agataaatga ggactctaaa ccatgaacta ataaatcagc
     2521 ggtggctgaa caaa
//
LOCUS       NM_001437040            3288 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus myosin IG (Myo1g), mRNA.
ACCESSION   NM_001437040 XM_006251218
VERSION     NM_001437040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Gerard,A., Patino-Lopez,G., Beemiller,P., Nambiar,R., Ben-Aissa,K.,
            Liu,Y., Totah,F.J., Tyska,M.J., Shaw,S. and Krummel,M.F.
  TITLE     Detection of rare antigen-presenting cells through T cell-intrinsic
            meandering motility, mediated by Myo1g
  JOURNAL   Cell 158 (3), 492-505 (2014)
   PUBMED   25083865
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Maravillas-Montero,J.L., Lopez-Ortega,O., Patino-Lopez,G. and
            Santos-Argumedo,L.
  TITLE     Myosin 1g regulates cytoskeleton plasticity, cell migration,
            exocytosis, and endocytosis in B lymphocytes
  JOURNAL   Eur J Immunol 44 (3), 877-886 (2014)
   PUBMED   24310084
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Dart,A.E., Tollis,S., Bright,M.D., Frankel,G. and Endres,R.G.
  TITLE     The motor protein myosin 1G functions in FcgammaR-mediated
            phagocytosis
  JOURNAL   J Cell Sci 125 (Pt 24), 6020-6029 (2012)
   PUBMED   23038771
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Olety,B., Walte,M., Honnert,U., Schillers,H. and Bahler,M.
  TITLE     Myosin 1G (Myo1G) is a haematopoietic specific myosin that
            localises to the plasma membrane and regulates cell elasticity
  JOURNAL   FEBS Lett 584 (3), 493-499 (2010)
   PUBMED   19968988
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced XM_006251218.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.52685.1,
                                           SRR26643290.45097.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000014.1  85615546-85615747   c
            203-411             JAXUCZ010000014.1  85613855-85614063   c
            412-505             JAXUCZ010000014.1  85613610-85613703   c
            506-671             JAXUCZ010000014.1  85612708-85612873   c
            672-725             JAXUCZ010000014.1  85612431-85612484   c
            726-836             JAXUCZ010000014.1  85611929-85612039   c
            837-953             JAXUCZ010000014.1  85611594-85611710   c
            954-1178            JAXUCZ010000014.1  85610938-85611162   c
            1179-1324           JAXUCZ010000014.1  85610705-85610850   c
            1325-1439           JAXUCZ010000014.1  85609843-85609957   c
            1440-1610           JAXUCZ010000014.1  85609506-85609676   c
            1611-1681           JAXUCZ010000014.1  85609216-85609286   c
            1682-1756           JAXUCZ010000014.1  85606795-85606869   c
            1757-1889           JAXUCZ010000014.1  85606346-85606478   c
            1890-2056           JAXUCZ010000014.1  85605675-85605841   c
            2057-2264           JAXUCZ010000014.1  85605085-85605292   c
            2265-2488           JAXUCZ010000014.1  85604236-85604459   c
            2489-2633           JAXUCZ010000014.1  85603593-85603737   c
            2634-2738           JAXUCZ010000014.1  85602289-85602393   c
            2739-2852           JAXUCZ010000014.1  85601962-85602075   c
            2853-3007           JAXUCZ010000014.1  85600973-85601127   c
            3008-3288           JAXUCZ010000014.1  85600619-85600899   c
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3288
                     /gene="Myo1g"
                     /note="myosin IG"
                     /db_xref="GeneID:289785"
                     /db_xref="RGD:1306016"
     exon            1..202
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3164
                     /gene="Myo1g"
                     /note="myosin-Ig"
                     /codon_start=1
                     /product="unconventional myosin-Ig"
                     /protein_id="NP_001423969.1"
                     /db_xref="GeneID:289785"
                     /db_xref="RGD:1306016"
                     /translation="MEDEEGPEYGKPDFVLLDQLTMEEFMKNLQLRFEKGRIYTYIGE
                     VLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISG
                     ESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSS
                     RFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQE
                     LHLERNPAVYNFTRQGAGLNMGVHNALGSDEKSHQGVMEAMKIIGFSPEEVESIHRIL
                     AAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPSDLVLRTLLARTVASG
                     GREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRDRDPRRDGKDTVIG
                     VLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSIEYFNN
                     ATIVELVEQPRRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKT
                     MEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSMDPTLRAMWPDGQQDI
                     TEVTKRPLTAGTLFKNSMIALVENLASKEPFYVRCIKPNEDKVPGRLDEAHCRHQVEY
                     LGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDREAVSALLEQHGLQG
                     DVAFGHSKLFIRSPRTLVTLEQSRAHLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIM
                     GWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCHILFSRWRAR
                     QLVKNIPPSDMTQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQ
                     LKALREKDGFGTVLFSSHVRKVNRFRKRRDRALLLTDRHLYKLEPGRQYRVMRAVPLD
                     AVTGLSVTSGRDQLVVLHAQGHDDLVVCLHRSQPPLDNRIGELVGMLVSHCQGEGRTL
                     EIRVSDCIPLSQRGARRLISVEPRPEQTEPDFQCSRSTFTLLWPSH"
     misc_feature    174..2189
                     /gene="Myo1g"
                     /note="class I myosin, motor domain; Region: MYSc_Myo1;
                     cd01378"
                     /db_xref="CDD:276829"
     misc_feature    174..2189
                     /gene="Myo1g"
                     /note="class I myosin, motor domain; Region: MYSc_Myo1;
                     cd01378"
                     /db_xref="CDD:276829"
     misc_feature    order(255..266,279..281,411..434,558..590,1290..1307)
                     /gene="Myo1g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(255..266,279..281,411..434,558..590,1290..1307)
                     /gene="Myo1g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(255..266,279..281)
                     /gene="Myo1g"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(255..266,279..281)
                     /gene="Myo1g"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    411..434
                     /gene="Myo1g"
                     /note="P-loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    411..434
                     /gene="Myo1g"
                     /note="P-loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    558..590
                     /gene="Myo1g"
                     /note="switch I region; other site"
                     /db_xref="CDD:276829"
     misc_feature    558..590
                     /gene="Myo1g"
                     /note="switch I region; other site"
                     /db_xref="CDD:276829"
     misc_feature    1290..1307
                     /gene="Myo1g"
                     /note="switch II region; other site"
                     /db_xref="CDD:276829"
     misc_feature    1290..1307
                     /gene="Myo1g"
                     /note="switch II region; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(1377..1412,1419..1442,1446..1448)
                     /gene="Myo1g"
                     /note="relay loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(1377..1412,1419..1442,1446..1448)
                     /gene="Myo1g"
                     /note="relay loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    1983..2015
                     /gene="Myo1g"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276829"
     misc_feature    1983..2015
                     /gene="Myo1g"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(2019..2099,2148..2189)
                     /gene="Myo1g"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(2019..2099,2148..2189)
                     /gene="Myo1g"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276829"
     misc_feature    2550..3065
                     /gene="Myo1g"
                     /note="Unconventional myosin tail, actin- and
                     lipid-binding; Region: Myosin_TH1; pfam06017"
                     /db_xref="CDD:461801"
     misc_feature    2550..3065
                     /gene="Myo1g"
                     /note="Unconventional myosin tail, actin- and
                     lipid-binding; Region: Myosin_TH1; pfam06017"
                     /db_xref="CDD:461801"
     exon            203..411
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            412..505
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            506..671
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            672..725
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            837..953
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1178
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1324
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1439
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1610
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1681
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1756
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1889
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2056
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2264
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2488
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2633
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2738
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2852
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3007
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3288
                     /gene="Myo1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttctgc aggagttagg cagtgctggg cctccccttt ctgtcttccc cttgacctct
       61 gtacagaaag ctctggcgtc ctggtctgga ggcttccagt gggcaggatg gaggatgaag
      121 aaggtcctga gtatgggaaa ccagactttg tgcttttgga ccaactaaca atggaggagt
      181 ttatgaagaa cctacagctc aggtttgaga agggccgtat ctatacctac attggcgagg
      241 tgctggtatc tgtgaacccc taccaggaac tgccattgta tgggccagag gccattgcca
      301 agtaccaggg ccgtgagctc tatgagcgac cacctcatct ttacgccgtg gccaatgctg
      361 cttacaaggc aatgaagcgc agatccaggg acacctgcat tgtcatctca ggggagagtg
      421 gagcagggaa gacggaagcc agcaagcaca tcatgcagta cattgctgct gtcaccaacc
      481 caagccagag ggctgaggta gagagggtga aggacgttct tctcaagtct acctgtgtgc
      541 tggaagcctt tggcaatgcc cgcaccaacc gcaaccacaa ctccagccgc tttggcaagt
      601 acatggacat caacttcgac ttcaaggggg atcctgttgg aggacacatc cacagctacc
      661 tgctagagaa gtctagggtt ctcaagcagc atgtggggga gaggaacttc catgctttct
      721 accagttgct tcggggcagc gaggaccaag agctgcaaga gctgcatctg gagagaaatc
      781 ccgctgtgta taatttcacg cgtcagggag ctgggctcaa catgggtgtg cacaatgcct
      841 tgggtagtga tgagaagagc caccaaggag tgatggaggc catgaagatt atcggcttca
      901 gtcccgagga ggtagaatcc atccatcgta tcctagccgc catattgcac ctgggaaaca
      961 tcgaatttgt ggagacagag gaaaatggac cacagaaagg aggcctggaa gtggcagacg
     1021 aggccctggt aggatatgtg gccaagctga cagccacccc cagcgacctc gttctgcgaa
     1081 ccctgctggc tcgtacagtg gcttcagggg gccgagaggt cattgagaag agccacactg
     1141 tggctgaggc cagctatgcc cgggacgcct gtgcaaaggc aatgtaccag cgactgtttg
     1201 agtgggttgt gaacaagatc aacagcatca tggaaccccg ggaccgggac cctcggcgtg
     1261 atggcaagga cactgtcatt ggggtgctgg acatctacgg ctttgaagta ttccctgtca
     1321 acagctttga gcagttctgt atcaactact gcaatgagaa gctccagcag ctctttatcc
     1381 agctgattct gaagcaagag caggaggagt atgagcgaga aggcatcacc tggcagagca
     1441 tcgagtactt caacaacgcc accattgtgg aacttgtaga gcagccccgc cgaggcatcc
     1501 tggctgtact agatgaagcc tgcagcacgg caggccccat cactgaccgg atcttcctgc
     1561 agaccctgga cacacaccac cgccaccacc cacactattc cagccgccag ctttgcccta
     1621 cggacaagac catggagttt ggccgagact tccagatcaa acactatgca ggggatgtca
     1681 cgtactctgt ggaaggcttc attgacaaga atagagactc tctcttccag gacttcaaac
     1741 ggctgctgta caatagcatg gatcccacct tgcgagccat gtggccagac gggcaacagg
     1801 acatcacaga agtgaccaag cgccccctga cagccggcac actctttaag aattccatga
     1861 ttgccctggt ggagaacttg gcctccaagg agcccttcta tgtccgctgc ataaaaccca
     1921 acgaagacaa ggtacccgga cgactcgatg aagcccactg tcgtcaccag gtcgagtacc
     1981 tgggattact ggagaatgtg agggtccgca gggctggctt tgcttcccgg cagccctacc
     2041 ctcggttcct gctcaggtac aagatgacct gtgagtacac atggcccaac cacctgctgg
     2101 gctctgacag ggaggcggtg agcgcccttc tggagcagca tgggctacaa ggggatgtgg
     2161 cctttggtca cagcaagctg ttcatccgat ccccaaggac gctggtcact ctggagcaga
     2221 gccgagctca cctgattcct atcattgtgt tactgctgca gaaggcttgg cggggcaccc
     2281 tggccaggtg gcgctgcagg cgactgaggg ccatctacac catcatgggc tggttccgga
     2341 ggcacaaagt acgcgctcac ctgattgaac tacagcgacg gttccaggct gcacggcagc
     2401 ccccactcta tggccgtgac cttgtgtggc caacaccacc cgctgtgctg cagccgttcc
     2461 aggatacttg ccatattctc ttcagcaggt ggcgggcacg gcagttagtg aagaacatcc
     2521 ctccttcaga catgacccag atcaaggcca aggtggctgc tatgggggcc ttgcaaggat
     2581 tgaggcagga ctggggctgc cagagggcct gggcccgaga ctacctgtcc tctgacactg
     2641 acaaccccac agcttcccat ctgttcgctg agcagctaaa ggcacttcgg gagaaggatg
     2701 gcttcggaac cgtgcttttc tccagccacg tgcgcaaggt gaatcgattc cgcaagcgcc
     2761 gggaccgggc ccttctgctc acagaccggc atctctacaa gctggaacct ggacgacagt
     2821 accgggtgat gcgggctgtg cctctggatg cggtgacagg gctgagtgtg accagtggac
     2881 gggaccagct ggtggtgcta cacgcccaag gccatgatga tcttgtagtg tgtctacacc
     2941 gttcccagcc acccctagac aatcgaattg gggagctggt gggcatgctg gtttcacact
     3001 gccaggggga gggacgaacc ctggagatcc gtgtctctga ctgtatccca ctgagccagc
     3061 gtggtgcccg gcgcctcatt tccgtagagc ccaggccaga gcagactgag ccagatttcc
     3121 aatgcagccg cagtaccttt accctcctct ggccaagcca ctgagcaagc tcaagccagc
     3181 ctagcctggt ctccgcacag ttctagacac ctggtcttga ccgtactaaa ggctaggatt
     3241 tgtccacctt tatatagaat gccacaaaat aaagatgcta tatttgta
//
LOCUS       NM_001437041            5256 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus transducin (beta)-like 1 X-linked (Tbl1x), mRNA.
ACCESSION   NM_001437041 XM_039099665
VERSION     NM_001437041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5256)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   2  (bases 1 to 5256)
  AUTHORS   Oberoi,J., Fairall,L., Watson,P.J., Yang,J.C., Czimmerer,Z.,
            Kampmann,T., Goult,B.T., Greenwood,J.A., Gooch,J.T.,
            Kallenberger,B.C., Nagy,L., Neuhaus,D. and Schwabe,J.W.
  TITLE     Structural basis for the assembly of the SMRT/NCoR core
            transcriptional repression machinery
  JOURNAL   Nat Struct Mol Biol 18 (2), 177-184 (2011)
   PUBMED   21240272
REFERENCE   3  (bases 1 to 5256)
  AUTHORS   Perissi,V., Scafoglio,C., Zhang,J., Ohgi,K.A., Rose,D.W.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     TBL1 and TBLR1 phosphorylation on regulated gene promoters
            overcomes dual CtBP and NCoR/SMRT transcriptional repression
            checkpoints
  JOURNAL   Mol Cell 29 (6), 755-766 (2008)
   PUBMED   18374649
REFERENCE   4  (bases 1 to 5256)
  AUTHORS   Ishii,S., Kurasawa,Y., Wong,J. and Yu-Lee,L.Y.
  TITLE     Histone deacetylase 3 localizes to the mitotic spindle and is
            required for kinetochore-microtubule attachment
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4179-4184 (2008)
   PUBMED   18326024
REFERENCE   5  (bases 1 to 5256)
  AUTHORS   Li,J. and Wang,C.Y.
  TITLE     TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene
            promoter for transcription activation and oncogenesis
  JOURNAL   Nat Cell Biol 10 (2), 160-169 (2008)
   PUBMED   18193033
REFERENCE   6  (bases 1 to 5256)
  AUTHORS   Yoon,H.G., Choi,Y., Cole,P.A. and Wong,J.
  TITLE     Reading and function of a histone code involved in targeting
            corepressor complexes for repression
  JOURNAL   Mol Cell Biol 25 (1), 324-335 (2005)
   PUBMED   15601853
REFERENCE   7  (bases 1 to 5256)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
REFERENCE   8  (bases 1 to 5256)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
REFERENCE   9  (bases 1 to 5256)
  AUTHORS   Guenther,M.G., Lane,W.S., Fischle,W., Verdin,E., Lazar,M.A. and
            Shiekhattar,R.
  TITLE     A core SMRT corepressor complex containing HDAC3 and TBL1, a
            WD40-repeat protein linked to deafness
  JOURNAL   Genes Dev 14 (9), 1048-1057 (2000)
   PUBMED   10809664
REFERENCE   10 (bases 1 to 5256)
  AUTHORS   Bassi,M.T., Ramesar,R.S., Caciotti,B., Winship,I.M., De Grandi,A.,
            Riboni,M., Townes,P.L., Beighton,P., Ballabio,A. and Borsani,G.
  TITLE     X-linked late-onset sensorineural deafness caused by a deletion
            involving OA1 and a novel gene containing WD-40 repeats
  JOURNAL   Am J Hum Genet 64 (6), 1604-1616 (1999)
   PUBMED   10330347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 26, 2025 this sequence version replaced XM_039099665.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.44825.1,
                                           SRR26360186.282753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000021.1  45454406-45454670
            266-360             JAXUCZ010000021.1  45580881-45580975
            361-474             JAXUCZ010000021.1  45588384-45588497
            475-620             JAXUCZ010000021.1  45590125-45590270
            621-882             JAXUCZ010000021.1  45592879-45593140
            883-1015            JAXUCZ010000021.1  45594504-45594636
            1016-1157           JAXUCZ010000021.1  45594986-45595127
            1158-1221           JAXUCZ010000021.1  45595398-45595461
            1222-1319           JAXUCZ010000021.1  45595575-45595672
            1320-1380           JAXUCZ010000021.1  45596597-45596657
            1381-1502           JAXUCZ010000021.1  45597099-45597220
            1503-1577           JAXUCZ010000021.1  45600082-45600156
            1578-1705           JAXUCZ010000021.1  45600539-45600666
            1706-1871           JAXUCZ010000021.1  45601466-45601631
            1872-1973           JAXUCZ010000021.1  45605242-45605343
            1974-5256           JAXUCZ010000021.1  45606251-45609533
FEATURES             Location/Qualifiers
     source          1..5256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..5256
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="transducin (beta)-like 1 X-linked"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
     exon            1..265
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            266..360
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    318..320
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="upstream in-frame stop codon"
     exon            361..474
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..2000
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1X"
                     /protein_id="NP_001423970.1"
                     /db_xref="GeneID:302711"
                     /db_xref="RGD:1563868"
                     /translation="MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLV
                     PPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREK
                     LAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSK
                     PMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG
                     STQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLG
                     QHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT
                     FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK
                     QDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHT
                     LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARG
                     DKVGASASDGSVCVLDLRK"
     misc_feature    435..509
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="Region: LisH; pfam08513"
                     /db_xref="CDD:462501"
     misc_feature    435..509
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="Region: LisH; pfam08513"
                     /db_xref="CDD:462501"
     misc_feature    945..1865
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    945..1865
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; Region:
                     WD40; cd00200"
                     /db_xref="CDD:238121"
     misc_feature    order(957..959,1011..1013,1023..1025,1041..1046,
                     1110..1115,1179..1181,1191..1193,1209..1211,1245..1250,
                     1299..1301,1314..1316,1332..1337,1374..1376,1422..1424,
                     1437..1439,1455..1460,1494..1499,1551..1553,1563..1565,
                     1581..1586,1620..1625,1701..1703,1716..1718,1734..1739,
                     1773..1778,1830..1832,1842..1844,1860..1865)
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    order(957..959,1011..1013,1023..1025,1041..1046,
                     1110..1115,1179..1181,1191..1193,1209..1211,1245..1250,
                     1299..1301,1314..1316,1332..1337,1374..1376,1422..1424,
                     1437..1439,1455..1460,1494..1499,1551..1553,1563..1565,
                     1581..1586,1620..1625,1701..1703,1716..1718,1734..1739,
                     1773..1778,1830..1832,1842..1844,1860..1865)
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     misc_feature    969..1112
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    969..1112
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1140..1247
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1140..1247
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1260..1370
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1260..1370
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1389..1493
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1389..1493
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1509..1619
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1509..1619
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1635..1772
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1635..1772
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    <1785..1997
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="eight-bladed beta-propeller heme-binding domain in
                     cytochrome cd1 and similar proteins; Region:
                     8prop_heme_binding_protein; cl49617"
                     /db_xref="CDD:483957"
     misc_feature    <1785..1997
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="eight-bladed beta-propeller heme-binding domain in
                     cytochrome cd1 and similar proteins; Region:
                     8prop_heme_binding_protein; cl49617"
                     /db_xref="CDD:483957"
     misc_feature    1788..1862
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1788..1862
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1794..1898
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="propeller blade [structural motif]; Region:
                     propeller blade"
                     /db_xref="CDD:467722"
     misc_feature    1794..1898
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="propeller blade [structural motif]; Region:
                     propeller blade"
                     /db_xref="CDD:467722"
     misc_feature    1911..1991
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1911..1991
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            475..620
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            621..882
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1015
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1157
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1221
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1319
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1380
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1502
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1577
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1705
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1871
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1973
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..5256
                     /gene="Tbl1x"
                     /gene_synonym="RGD1563868"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcgacg ctccggagcg acaagccgcc agcgcccccg ccccgccgcc gctgcagcgc
       61 cctccggccg ccattcgcca ccgaaacttt ccagcgcccg ctcttctcgt ggactaggtg
      121 gcgggcctgg ggcagcgcgc ggctgctccg gggcgcttgg ccctcgtcgg cctccgcgcg
      181 gcccggggtt ggtgacggtg gacccgccag tacgctgagt gcgcggccac tttgcgcggc
      241 cacaagttgc acggctagca gcgagggtgg tcctggactt tgtgcacacc tctcaagttc
      301 tgtgattgga tgctgggtag cccactgctc cagaggtcta cacatgcact cactgtgacg
      361 agggtggctc acacttgatc gagacgaaga cctcatcgcc gcaaggtgag gctaagatga
      421 gcattaccag cgacgaggtg aactttctgg tatatcgcta cctccaggaa tcaggttttt
      481 cccattccgc cttcacgttt gggatcgaaa gccacattag ccagtccaac atcaatggta
      541 cactagtgcc accggctgcc ctaatctcca ttcttcagaa aggactgcaa tatgtggagg
      601 cggagatcag catcaacgag gatggcacgg tatttgatgg gcgtcccatt gagtccctat
      661 cgttaattga tgctgtgatg cccgatgtgg tacagacaag acagcaagct tttcgggaga
      721 agctcgccca acagcaagcc aatgcagcag ctgcagcagc agcagccgca gccacagcca
      781 caagcacagc ggccacaaca ccagcagctg ctgctcagca aaacccacca aagaatggag
      841 aagccaccgt gaatggggaa gaaaatggag cccatgcaat aaataatcac tcaaaaccaa
      901 tggaaataga tggagacgtt gaaattccac cgagtaaagc cacagtcctt cgaggccatg
      961 agtctgaagt gttcatttgt gcctggaatc ctgttagtga cctacttgct tctggatctg
     1021 gagactctac tgcgaggata tggaacctta atgagaacag caacgggggc tccacacagc
     1081 ttgtgctgag gcactgcatc cgtgaaggtg gacatgatgt tcccagtaat aaggatgtca
     1141 cctcattgga ctggaatagc gatgggacac tgttggcaac aggttcctat gatggttttg
     1201 caagaatatg gacagaagat ggtaacctag ccagcacctt gggtcaacac aaaggcccca
     1261 tctttgcctt gaagtggaac aaaaagggga attatatttt gagtgctggt gtagacaaga
     1321 caacaataat ttgggacgcc cacacaggag aagccaaaca acagtttcct tttcattcag
     1381 cacctgccct tgatgtggac tggcagaaca acactacctt tgcctcgtgc agcacagaca
     1441 tgtgcattca tgtgtgcagg cttggctgtg atcgcccagt caaaaccttc caaggacata
     1501 ctaatgaggt caatgctatc aaatgggatc cttctggaat gttgctagcc tcctgctctg
     1561 atgacatgac attaaagatc tggagtatga agcaggatgc atgtgtccat gacctccaag
     1621 ctcacagcaa agagatatat accatcaagt ggagtcccac aggaccagcc accagcaacc
     1681 cgaactccaa catcatgtta gcaagtgctt catttgactc tacggttcga ctgtgggatg
     1741 tggagcgagg cgtttgcatc cacacactga ccaagcatca ggagcctgtc tatagtgtag
     1801 cgttcagccc tgacggaaag tatttggcca gtggatcctt tgacaagtgt gtccatatct
     1861 ggaatactca gagtggaagt ctcgtccaca gctaccgagg aacaggcggc atatttgagg
     1921 tgtgctggaa tgctcgagga gacaaagtgg gtgccagtgc atctgatggc tctgtctgtg
     1981 ttttagatct ccgaaagtaa acacaaaatg tagaaaacaa aaccattcta atggagcagc
     2041 agtgaatgtg tgggattgca gcaccctttc ctatgatggg ctccaaactg tgtgaacttg
     2101 acttgttcga gtctacttgg aaatcacctg tccctggcca caggattatt tccccccctc
     2161 ccctaatctc catccagaag tttaaaacac aaacaaatac aaagtcatac gcatggttgt
     2221 atcacaggaa tatggtttct acctagaatg ctcagctggg gaaggatgaa gcaagccatc
     2281 agctacatgg tacatggttg gtttccatcc agaacaggct ctaatgactg aacagggaag
     2341 gaagaacaca aagctgtgcc aaaaaataat gaaaaggtta aaaaatgaaa gagaaaaaat
     2401 gctgtgataa accaaaaggg aggaaaaacc tgtcccttat ggtgtttccc tcctatcaat
     2461 ttggatacta cagttgctcc aaaagaccag tttgtaccaa tgaaatgtgt gactttgtaa
     2521 tcccaacgct gtattttcta gaaccttctt tggtggtttt tctatctgct aaaattctgt
     2581 ggtctggggg cttcccacct cagatgaaaa ctgtttttgg cttattcctt ctgtcctccc
     2641 ttgttgtttc ccaccccttc ctctgatgtc cttgctctgg tgtggtctca cttctaatga
     2701 aatcctgcat agatatggcc acatgcacac agtggatctt tgttggacag cactctcctt
     2761 ccctctctcc cactcctacc tattgcttac tctgtccctt tctcatagtt gcttcacatt
     2821 aggtcccaaa ggcactttca gagcatagta agtgctttat gtaagaaggc agggatgggg
     2881 actttttaca gaaaaaaaaa gacttactta taagagaaag aacctggagt attttttgaa
     2941 aaaaatattt ttatgttaaa atgactttaa aatcctaaaa tggccatcag acatagagag
     3001 ttttgtgaaa ttcatattta aaagactaag aagacactgg cagagtctga ggtgtctaat
     3061 tacccctttc ccttcagctt cacgaaaggc agttaggcaa gccgtggatt gggaagcgtc
     3121 ctatggaaga acaaggggat tgttttggca gctggtgggg aagaaagagc ccactggtta
     3181 ggcatcaagc agaatgctga actgtttggt acacatttcc ttcagcagcc aataggaaca
     3241 tagtgaagaa gccaccctga ccaggtgtgg ctcatggcac ctgccagcta catctttctc
     3301 acaacagtgt agctacagat gggcactttt atcaagagca tgcttggtga atcttgcaaa
     3361 actgacccaa aggcctcagt gtcactcagt cttgtgaaga cagtgagtct caagggagac
     3421 tttcaattgt aaaaatgaat tatgacccag gtagaatgtc actgatcatt tctgcccact
     3481 ttccaatttc tctgacagaa gattaggaca aagctttctt ttaaaaaatg agaaaaaaat
     3541 aggaaagaaa tttcggctat tttttaaaaa caaaataagg catagtgtgc ctggtaaagt
     3601 ttgccatcat tgaatcaggt ggcctttgtt catttcttgt cataacttga cactgacttg
     3661 tttctttaat tagtaatagg ggacagacca gaagggggct gcaagaggca gtatgaaggg
     3721 tccagtctgc agctgaggca agtgttactt agagaaaagt atacatatat gaagccaaaa
     3781 atcaaccagc aaggaaggtc aggtgctccc tacacaacaa atgttagcac caaaacatgt
     3841 attggcctcc actttgccat gtaaattatg tgagccctca aaatctaaag tgttgtgtat
     3901 tgagttgagt ggtgaatttg ggttctgcca cctaaatgct tagcaaagta agcccaagtt
     3961 gtgtggaaat ttgatcatag cagatgtctc tgtgtcagtg gatatgaagt tccctgccct
     4021 gagactgctt ttagctttag gatgtaattt tggaagtcca gataaatcct atcattgttc
     4081 cacaaataca tttctgttca tctctacaga agatcagctg ttagatgtca gcctattgta
     4141 aaggtatgac tttcatttga caagttctac attgctatat ggtggtaatg ggtaggtggc
     4201 acatatgggg ttcatcagac aatctctggg tgtccaggct acaccccccc tagatgaatc
     4261 taagccacat aagaattatt attttggagt caatggctgt aagactagga caaaaaggtt
     4321 caatctacat aaacctgaag accattcatt tccctggcct tacagctaaa catggacagg
     4381 aacttagtgc tggccacaca aggaccaagc agaagaatgc agcccacacc cctgaagttc
     4441 atccccataa gacagctcag tctgcagctg tttctggagc ggccagcatt tggacgccat
     4501 catttgcctg ctgttacagg gcaggtgcat catctttgtg atcaaggggt ggcccatgtg
     4561 ttatgctgtt acctaacatt gtttataact cctaaaaaca ttgtgaggaa tggttagtct
     4621 tgtgaccaaa ttcaaccttg aaagcagtgt agtcacatag cagcctttcc aggtaatttt
     4681 ccttgagttt gaagtaacca tataccattc ctagcacatc caggatgctg cctgtagagg
     4741 accgaagggc cagatggaca ttacaaagtt caactctctg accccactca acaccatagg
     4801 acttgacttt ttgttctgtc tgactaagaa atagaccatg gagccaagtg aagtgcactt
     4861 tgtcacatgt aaggatctgc tttgttcctt gttgcttttc cctttataaa cctttgttat
     4921 atctttccat tctgtttctt gtcaaatgca taaatgtctg ttctgcaact cactgaagtt
     4981 ttgaattctg gcttgtgcag tttttattgt ctgtgtcaga cgtacagcca gacatggtcc
     5041 tctttcaaca ttttccacat tctgttaagc accatcaaaa ctcccctccc cctctgtcct
     5101 ctcccccacc cccactccca ttcaccccac acgctcttcg agaagaaaaa aaaaagaatc
     5161 accttgtgtg ttgtagctca tttgtttcaa gagagaatca acagatcata ttcagtgtct
     5221 tgaataaatt gctctatttt gatattagag aacata
//
LOCUS       NM_001100889            6781 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus shroom family member 3 (Shroom3), mRNA.
ACCESSION   NM_001100889 XM_001070669 XM_223229
VERSION     NM_001100889.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Yeo,N.C., O'Meara,C.C., Bonomo,J.A., Veth,K.N., Tomar,R.,
            Flister,M.J., Drummond,I.A., Bowden,D.W., Freedman,B.I., Lazar,J.,
            Link,B.A. and Jacob,H.J.
  TITLE     Shroom3 contributes to the maintenance of the glomerular filtration
            barrier integrity
  JOURNAL   Genome Res 25 (1), 57-65 (2015)
   PUBMED   25273069
  REMARK    GeneRIF: variants disrupting the actin-binding domain of SHROOM3
            may cause podocyte effacement and impairment of the glomerular
            filtration barrier
REFERENCE   2  (bases 1 to 6781)
  AUTHORS   Hildebrand,J.D.
  TITLE     Shroom regulates epithelial cell shape via the apical positioning
            of an actomyosin network
  JOURNAL   J Cell Sci 118 (Pt 22), 5191-5203 (2005)
   PUBMED   16249236
REFERENCE   3  (bases 1 to 6781)
  AUTHORS   Klezovitch,O., Fernandez,T.E., Tapscott,S.J. and Vasioukhin,V.
  TITLE     Loss of cell polarity causes severe brain dysplasia in Lgl1
            knockout mice
  JOURNAL   Genes Dev 18 (5), 559-571 (2004)
   PUBMED   15037549
REFERENCE   4  (bases 1 to 6781)
  AUTHORS   Hildebrand,J.D. and Soriano,P.
  TITLE     Shroom, a PDZ domain-containing actin-binding protein, is required
            for neural tube morphogenesis in mice
  JOURNAL   Cell 99 (5), 485-497 (1999)
   PUBMED   10589677
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_223229.4, XM_001070669.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760400
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000014.1  15680099-15680263   c
            166-320             JAXUCZ010000014.1  15574091-15574245   c
            321-452             JAXUCZ010000014.1  15429579-15429710   c
            453-584             JAXUCZ010000014.1  15414419-15414550   c
            585-3789            JAXUCZ010000014.1  15407033-15410237   c
            3790-3860           JAXUCZ010000014.1  15400919-15400989   c
            3861-4679           JAXUCZ010000014.1  15397312-15398130   c
            4680-5168           JAXUCZ010000014.1  15395434-15395922   c
            5169-5319           JAXUCZ010000014.1  15393474-15393624   c
            5320-5592           JAXUCZ010000014.1  15386547-15386819   c
            5593-6781           JAXUCZ010000014.1  15383769-15384957   c
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..6781
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="shroom family member 3"
                     /db_xref="GeneID:305230"
                     /db_xref="RGD:1310470"
     CDS             1..5961
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /codon_start=1
                     /product="protein Shroom3"
                     /protein_id="NP_001094359.1"
                     /db_xref="GeneID:305230"
                     /db_xref="RGD:1310470"
                     /translation="MRTPENLEEPSATPNSSRTPKERYVYLEALLEGGAPWGFTLKGG
                     LEHGEPLIISKIEEGGKADSVSSGLQTGDEVIHINEVVLSSSRREAVSLVKGSYKTLR
                     LVVRRDVCAAPGHADPGTSNSISSELLTCSPQHRKATWSGGVKLRLKQRCSEPAARPH
                     SWHTTKFGETQADVSMMRISQGTVGPPWHQSCHSSSSTSDLSNYDHAYLRRSPDRCSS
                     QGSMESLGPRGGSPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPG
                     GSARERSGSLDMIPARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRD
                     AHTSADSQGCAKWHSIPRGKGTPPLPWSQQCSGSPETADNPPHKAGAPMPPTRSDSYV
                     ALRHRERPSSWSSLDQKRFCRPQTNSLGSQKTPFVEEQLHTVPERSPENSPPVKPKHN
                     YTQKTQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSGNGTVYPALVKESGYTAAQGTCS
                     KMAALDENGNQKEVSRPGFAFCQPPEHDSMTPVEKKPEPRAKYIPYKVHFSSVPENED
                     SSLKRHVTPPHGNSLYPSERKNVHGGGSRPCSNHHSLPSAQAQAPHAGDDDRRPSRLF
                     QPWEGDFQEDHNANLRQKVEREGQGQGLPGNSGGTKSTFSPLQNIPENLRRQSSVDLG
                     EGLEVYPGGRSTCATTTTKVEDPGRKAGPDNRGYLDRSVSYPRPEGKMNAAESFHSAD
                     SRYEEPLAAPPQQTSGMSQRRLSASSTPALQYKKPHCSVLEKVSKIEEREQGRHRPTS
                     VGSSAYALSYRPGRTGPTPSTSSSDLDDPKASSSHFSESAAEHLRNGEQNPPNGEPKL
                     EEASRQQCNQLLRRTTADGRGPPARGSEPSRPEARLLRSQSTFQLFSEAEREASWSED
                     RPSTPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASA
                     HVGMRSPEASAPLSSPHTPRERHSVTPATGTPPAPQAARRGARRRLTAEQKKRSYSEP
                     EKMNEVGVSEEAESVHCVPQRPAQLRFSESTVADRRRLFERDGKACSTLSLSGPELKQ
                     FQQSALADYIQRKTGKRPTGAACTPEPGLRERAQSVYFQAVPAAPEGPGLASACSLSS
                     LREPEVLPCKEHPHQSAADGPQTPRDRSSSFASGRLVGERRRWDPQAPRQLLSGANCG
                     PRGVQRMDRTSRGPPSWDMVVGKSGKSKSAEDLLERSDTLTVPVHVRSRSSPTSDKKG
                     QDVLLREDSGFGFVKDPYLAGPGSRPLSYSDRGQKEQALPLHHPATCWNGSGYKATVV
                     SSTESSGAPDHLKQLRAPCPRPLSAGMHGHFPDARASSVAPLSSPLPSPVPSGYRSQL
                     DMDQQMGHQPLPSPASAVTQPPSPRSHELEEGMWKRASLPQRPPRPWKWAHAVREDGL
                     AEDASSAPEFATLKHYKNQLSLPSSCSTSDPDTPGRISLRISESALQASPPPRGDYDD
                     EVFVKDLHPKVPSSPTFEALPPPPPPPSPLSQEPLTCGSDDFPSPPPQAMCEAPLDGE
                     VSEEPGSGSCGLPRVTATREGQVPGAGHAEGSQIMVAIPPQTSAEGSAAESSTAARVS
                     AQPPLHSFPGKQPCPSQARNLTYEPADRTQDLGKKIHAEPQKTSEDIRTEALAKEIVH
                     QDKSLADILDPDSRMKTTMDLMEGLFPRDAGVLKENAERRAVDSTTRRAGWEVETSDH
                     KEAAGVLVNCPAYYSVSAAKAELLNKIKDMPEELREEEEQEDVNEKKAELIGSLTHKL
                     ETLQEAKGSLLTDIRLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLS
                     GRLARVENVLSGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILA
                     NYLSAEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAIS
                     LPPALASHVTPGGGPAFGGVFPTLTSPL"
     misc_feature    76..321
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="PDZ domain of shroom2, shroom3, shroom4, and
                     related domains; Region: PDZ_shroom2_3_4-like; cd06750"
                     /db_xref="CDD:467232"
     misc_feature    76..321
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="PDZ domain of shroom2, shroom3, shroom4, and
                     related domains; Region: PDZ_shroom2_3_4-like; cd06750"
                     /db_xref="CDD:467232"
     misc_feature    order(106..126,160..162,169..171,259..261,271..273,
                     280..285)
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467232"
     misc_feature    order(106..126,160..162,169..171,259..261,271..273,
                     280..285)
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467232"
     misc_feature    <2236..3015
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="104 kDa microneme/rhoptry antigen; Provisional;
                     Region: PTZ00449"
                     /db_xref="CDD:185628"
     misc_feature    <2236..3015
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="104 kDa microneme/rhoptry antigen; Provisional;
                     Region: PTZ00449"
                     /db_xref="CDD:185628"
     misc_feature    2671..3222
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="Apx/Shroom domain ASD1; Region: ASD1; pfam08688"
                     /db_xref="CDD:462562"
     misc_feature    2671..3222
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="Apx/Shroom domain ASD1; Region: ASD1; pfam08688"
                     /db_xref="CDD:462562"
     misc_feature    4981..5838
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="Apx/Shroom domain ASD2; Region: ASD2; pfam08687"
                     /db_xref="CDD:462561"
     misc_feature    4981..5838
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /note="Apx/Shroom domain ASD2; Region: ASD2; pfam08687"
                     /db_xref="CDD:462561"
     exon            1..165
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            166..320
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            453..584
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            585..3789
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3860
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4679
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..5168
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5319
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5592
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
     exon            5593..6781
                     /gene="Shroom3"
                     /gene_synonym="RGD1310470; Shrm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggaccc ccgagaactt ggaggagcct agcgccactc caaactccag caggaccccc
       61 aaggagagat acgtttatct ggaagcgctc ctagagggag gggctccctg gggcttcacc
      121 ctgaaaggtg gcctggagca tggagaacca ttaattattt ccaagatcga agaaggcggg
      181 aaggctgact ccgtgagctc cggactgcaa actggagatg aagtcataca catcaatgag
      241 gtggtgctga gcagctccag gagagaggct gtctccctgg tgaaaggatc ctacaagacc
      301 ctccggctgg tggtacgcag agacgtgtgt gcagccccgg gccatgcaga tcctggtacc
      361 tcgaattcca tcagctcaga gctgctcacc tgcagtcccc agcaccggaa agcaacatgg
      421 tcaggagggg tgaaacttcg gctaaagcag aggtgcagtg aacctgccgc tcgcccacac
      481 tcgtggcata ccaccaaatt tggagagacc caggctgacg tcagcatgat gcggatatct
      541 cagggcacag tgggccctcc ttggcaccag agctgccatt ccagctcttc tacgagtgac
      601 ctctccaact acgaccatgc ttatctgagg cggagccctg accggtgcag ctcccagggg
      661 agcatggaaa gcctgggtcc ccgtggcggg tccccacctt gccatcttct ttcccctgcc
      721 aagtccacga gcagcatcga ccagctaggc caccttcata acaaaagaga ctcggcctac
      781 agctccttct ccaccagttc cagcatcttc gagtacccgc ccccgggtgg ctctgcccga
      841 gaacgttcag gctccctgga catgattcct gcccggggcg gcctcctaga agggatgagg
      901 caggcagaca ttcgctatgt caagacagtt tacgataccc ggaggggagt atcttcagag
      961 tatgaggtga acccttcagc cttgcttctt caaggtaggg atgcccacac ctcagcagac
     1021 agtcagggct gtgctaaatg gcacagcatt cctcggggca agggaacacc tcccctgcct
     1081 tggagccagc agtgttctgg ttccccggag actgcggaca acccacccca taaggctggc
     1141 gcacccatgc ccccaactcg cagtgacagt tatgtggccc tccggcatcg tgagcgtccc
     1201 agctcctggt ccagccttga tcagaaaagg ttctgccgtc ctcagacgaa ctctttgggc
     1261 tcccagaaaa ccccattcgt cgaggaacag ctacataccg tcccagagag gagcccggag
     1321 aacagccccc cagtgaaacc taagcataat tatacccaga agacgcagcc tggccaacct
     1381 ctactgccca cgggcatcta tccggtacct tctccagagc ctcactttgc ccaggtgccc
     1441 cagccctctg tgagtggtaa tggtacagtc taccctgcac tggtcaaaga gagtggatac
     1501 acagctgctc agggaacttg tagcaagatg gctgccttag acgagaacgg gaatcaaaaa
     1561 gaagtgagca ggcctgggtt tgccttctgt cagcccccag aacacgactc gatgactcca
     1621 gtggagaaaa agccagaacc cagggccaaa tacatcccct acaaagtcca tttttcttca
     1681 gtgcctgaaa atgaagactc ctccctcaag agacacgtca cacctcccca cggcaatagc
     1741 ctatacccca gcgagagaaa gaacgttcac ggtggtggca gcagaccgtg ttctaatcac
     1801 cacagtctcc cgtccgctca agcccaggcc ccgcacgcgg gtgatgatga caggaggcct
     1861 tccaggctct tccagccctg ggagggtgac tttcaggaag atcacaatgc caacctcagg
     1921 cagaaagtgg agagggaagg ccaaggccag ggcctgccag gcaactctgg tgggaccaaa
     1981 tcgaccttct cacctctcca gaatattcca gaaaatctaa gaagacaaag cagcgtggac
     2041 ctaggagaag gcctggaggt ttaccccggt ggcagatcca cctgtgccac caccaccacc
     2101 aaggtggagg accctgggag gaaagcaggg cccgacaaca ggggctacct ggacaggtct
     2161 gtttcctatc caaggcccga ggggaaaatg aacgctgcag aatccttcca cagtgcagac
     2221 tccaggtatg aagagcccct ggccgcgcca ccgcagcaga catccggtat gagccagagg
     2281 aggctcagtg ccagcagtac ccctgccctg cagtacaaga agccccactg ctccgtgctg
     2341 gagaaggttt ctaagataga ggagcgagag caagggcgcc acagacccac gagtgtgggc
     2401 agctccgctt acgccctcag ctacaggcct ggtaggactg gccccactcc tagtacttcc
     2461 agcagtgacc ttgatgatcc aaaagccagc agctcccatt tctctgagtc cgccgccgaa
     2521 cacctgcgaa atggggagca gaacccccca aacggggagc ccaaactgga agaggcttcc
     2581 aggcagcagt gcaaccagct gctgaggagg accactgcag atggccgtgg acctcctgcc
     2641 cgaggcagcg agccctcaag gcccgaggcc cgcctgctcc gcagccagag cacctttcag
     2701 ctcttcagtg aggcggagag agaagcctcg tggtcggagg ataggcccag cacccccgag
     2761 tcacccctcc tagacgcacc cttcagccgc gcctacagga acagcatcaa ggatgcccag
     2821 tcccgtgtcc tgggggccac atcatttcgt cgccgggacc tggaaccggg cacccccgcg
     2881 acttcgaggc cttggcgccc gcgacccgcc tctgcccacg tgggcatgcg gagccccgag
     2941 gcctcggcac ccttgtcctc cccgcacacc cctcgggaga gacacagcgt gaccccggcc
     3001 acagggaccc cgcctgcacc ccaggctgcc cgcagagggg cacgccggcg cctcacagcc
     3061 gagcagaaga agcgttccta ctcggagccg gagaagatga acgaggtcgg ggtctcggag
     3121 gaggctgagt ccgtgcactg cgtcccacag aggccagcgc agctgcgctt ctcggagagc
     3181 accgtggccg accggcgacg cctcttcgag cgcgacggca aggcctgctc cacgctcagc
     3241 ctgtctggcc ctgaactgaa gcagttccag cagagcgccc tggccgacta catccagcgc
     3301 aagaccggca agcggcccac tggagctgcc tgcacgccgg aacccgggct gcgcgagcgc
     3361 gcacagagcg tctactttca ggcggtcccc gcggcgcccg aaggccccgg cctggcctcc
     3421 gcctgcagcc tgagttcgct acgggagccc gaggtgctgc cctgcaagga gcacccccat
     3481 cagtccgccg cagatggtcc acagacgccc cgagatcgca gcagctcctt tgccagcgga
     3541 cgcctagtcg gggagcgacg acgctgggac cctcaggccc ccaggcagct gctcagtgga
     3601 gctaactgcg gacccagggg cgtccagagg atggacagga cctccagagg gccgccttcc
     3661 tgggacatgg tggtcgggaa gtcagggaag tccaagtcag ccgaggatct gctggagcgc
     3721 tcggacacac tgaccgttcc tgtgcatgtg aggtccaggt cgtctcccac ctcggacaag
     3781 aaaggtcagg atgtgctcct cagagaagac agtggctttg gttttgtgaa ggatccatat
     3841 ttggctggcc ctggatctag gcctctcagc tactcggaca gaggccaaaa ggagcaggca
     3901 ttgcccctgc accatcctgc cacttgctgg aatggctcag gctacaaagc cactgtggtt
     3961 tcctctactg aatcttccgg agccccagat catctgaagc aacttagagc accttgccct
     4021 aggccacttt cagcaggaat gcacggccac ttcccagatg ccagagcctc ctccgtggcc
     4081 cccctcagct cccctctgcc atcacctgtc ccctccggtt accgctcaca gcttgacatg
     4141 gatcagcaga tgggacatca gcctctcccc tcccctgcct ctgcagtgac gcagcctccc
     4201 agcccaagaa gccatgagct agaggaggga atgtggaaga gggcgtccct gcctcagcga
     4261 ccccctcgac cttggaagtg ggcccacgca gtccgagagg acggccttgc tgaggacgcc
     4321 tcatcggcgc ctgagtttgc aaccctgaag cactataaaa accagctgag tcttccgagt
     4381 tcgtgcagca cttctgaccc agacactcca gggaggatct ctctccgaat atccgagtca
     4441 gccctacaag cttccccgcc accccggggg gactatgatg atgaggtgtt cgtgaaggac
     4501 ttgcacccca aggttccttc aagccccaca tttgaagctc tccccccgcc cccaccacca
     4561 ccttctccac tgagccagga gcctctaacg tgtggctcag atgactttcc ttcacctcct
     4621 ccccaagcca tgtgtgaggc accgctggat ggcgaagtat cggaggagcc cggcagcggt
     4681 tcctgcggac ttcccagggt gacagccacg agggaaggac aggtgcccgg ggcaggccat
     4741 gcagaaggaa gtcagataat ggttgccatc ccaccccaaa cttcggccga aggctcagca
     4801 gccgagtcca gcactgctgc ccgagtgagc gcccagcctc cgctccacag ttttcctggc
     4861 aagcagccct gtcccagcca ggcccgaaac ctcacttacg aacctgctga cagaactcag
     4921 gatctaggga agaaaatcca tgctgagccc cagaagactt cagaagatat ccgaacggag
     4981 gctctcgcca aggaaattgt ccaccaagac aagtctctgg cggacatttt ggacccggac
     5041 tccagaatga agaccacgat ggatctgatg gagggtctgt tccccaggga tgctggtgtg
     5101 ctgaaggaga acgctgagag gagagccgta gacagcacca ccaggcgtgc tgggtgggaa
     5161 gtcgagacga gcgaccacaa ggaggcagcg ggtgtgctgg tcaactgccc tgcgtactac
     5221 agtgtctctg ctgccaaggc ggaactgctg aacaaaatca aagacatgcc ggaggagctg
     5281 cgggaggagg aggagcagga ggacgtcaat gagaaaaagg ctgagctcat tggaagcctc
     5341 acccacaagc tggagaccct gcaggaagcg aaggggagtc tgctcacgga catcagactg
     5401 aacaatgccc tgggggagga ggtggaggcc ctgatcagtg agctctgcaa acccaacgag
     5461 ttcgacaagt acaagatgtt cataggcgac ttggacaagg tggtcaacct gctgctctcc
     5521 ctgtctggac gcctcgcccg agtagagaac gtcctcagtg gccttggtga agacgccagt
     5581 aaagaagaaa ggagttctct gaatgagaaa aggaaggttc tggctggcca gcatgaggat
     5641 gcccgggagc tcaaggagaa cctggaccgg agggagcgcg tggtgctgga tatcctggcc
     5701 aattacctgt ccgccgagca gctccaggac taccagcact tcgtgaaaat gaagtccaca
     5761 ctcctcatcg agcagcggaa gctggatgac aaaataaagc tgggccagga gcaggtcagg
     5821 tgtctgctgg agtcgctgcc ctcagacttc aggcccaagg caggggccat ctccctgccc
     5881 ccagccctcg ccagtcatgt gactcctggg gggggccctg cattcggtgg cgttttccca
     5941 acgttgacct ctcctcttta acctctcctg aaagacccga gcaaaagatg ccactctcaa
     6001 cactgttgaa tctgaaagat atttcaccac caaccacggt ttgagttgtg ggttattggg
     6061 ggcttcctga ggaaacggaa gagactatcc aggagtcttt gtgcctttca cagttggtct
     6121 tctacgagct tgcacacagc gggagccttt ccactctgtg ggaggaaagc cggtgacact
     6181 gagagagacc cgatgaaggg tgtctgatgt gcaggtttcc tcaggccaag gtgtcgtaga
     6241 ggaaggtgtg gcgccctcag gaatgtatcg gtggccttcc ttgctggcgg gcagtgcacc
     6301 ctgacacaaa gccttaaaaa gacatgcgcg cgcacacaca cacacacaca cacacacaca
     6361 cacacacaca cacacacaca caaagaagac tgttaacccc tgaacatttt tgttatttat
     6421 atttttaaaa atgaaaaaga tcattgtttg tgtgctaacc acttagttga ttctgttttg
     6481 cggtggatgt agacaattat gtttgagcgt tgtatttcgc gaaaacctta atgaagaatt
     6541 ccaaagatag tcaagttgaa tatggagatt tttgtggggt ttttcttctc atttgctctt
     6601 tgaaaaatct atttggtgtg tatgtatttg atactgggtg gctgtgagtg ccgcaggtta
     6661 cgtgcagaat tagacaactt tatgtgggtt ctgaggcttg gacctcggcc atcagtcttt
     6721 tcatccactc agccatcgtc agatggtaat aaagaccagt ggccattcta cacttgtgtt
     6781 a
//
LOCUS       NM_001437035            1367 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 4 open reading frame
            36 (C14h4orf36), transcript variant 2, mRNA.
ACCESSION   NM_001437035 XM_017599327
VERSION     NM_001437035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced XM_017599327.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3348945.1,
                                           SRR26360181.1086271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000014.1  6363509-6363641
            134-268             JAXUCZ010000014.1  6364081-6364215
            269-423             JAXUCZ010000014.1  6369160-6369314
            424-1367            JAXUCZ010000014.1  6369536-6370479
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1367
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="similar to human chromosome 4 open reading frame
                     36"
                     /db_xref="GeneID:498330"
                     /db_xref="RGD:1564576"
     exon            1..133
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..268
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="upstream in-frame stop codon"
     CDS             204..557
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="AFF1 antisense RNA 1"
                     /codon_start=1
                     /product="uncharacterized protein C4orf36 homolog"
                     /protein_id="NP_001423964.1"
                     /db_xref="GeneID:498330"
                     /db_xref="RGD:1564576"
                     /translation="MAYGLPRRNTVQNILKGSCYKIQEPWDLAELTKTWYSNLTNINL
                     PFLGEIAFGSPMNLLAGQTKQDCPLPSMQTMALEKEYEAKRLAKLKSKENACKEMQVS
                     LREKSVGLRRPLQPK"
     misc_feature    204..554
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="Protein of unknown function (DUF4522); Region:
                     DUF4522; pfam15022"
                     /db_xref="CDD:434399"
     misc_feature    204..554
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /note="Protein of unknown function (DUF4522); Region:
                     DUF4522; pfam15022"
                     /db_xref="CDD:434399"
     exon            269..423
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1367
                     /gene="C14h4orf36"
                     /gene_synonym="Aff1-as1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcaagc aggagcagga gcaagcaagc aagcgcgttt ccgcggcggg gccgctgcga
       61 gtgcgcggcc atgtgcacct agggcgcgct gccctgggtc ggggccgcgg ccggcgcgcg
      121 gctgacctgc ggggcatagt gaatagagcg gcgcagatgt tacatcgggc ttctatgtaa
      181 ggaaacgatt gtgatcattt gtcatggcgt atggcttgcc gagaaggaac acagtgcaaa
      241 acattttgaa gggcagctgt tataaaatac aggaaccatg ggaccttgcg gagctcacaa
      301 agacctggta ttcaaacttg acgaacatca acttgccgtt cttgggagaa atcgcatttg
      361 gtagccctat gaatctcttg gcaggccaaa ccaaacaaga ctgcccgctc ccttcaatgc
      421 aaaccatggc acttgaaaag gagtacgaag caaagcgcct agcgaagctg aagtctaagg
      481 agaacgcgtg taaggagatg caggtttcac tgagggaaaa gagtgtcggc ctgagaagac
      541 cacttcagcc caagtgaccc gaccacgtag cgtcaaacct gaacctgttt ccggcatcca
      601 cgggcggcga agctttcgga ttcctccaca gtgtcaagta gacacagcac tgtgtctatg
      661 ggcgatgggg ccaatgttgc tagacctggc tcggcgaacg ctgacagagc ccccgggttc
      721 ctgccacact cctgttcttt gtgccccaca cagcagccct ctctgtaagt agatgagaac
      781 gcatctggag ttgagtcgtt ttgtgttcgc tcgtttcaat gtctgtaaga tcgcgtgcgg
      841 aagaggacag ttcttgtgag agtcagcgct ctgaagagac gtttgcgatc ccaaggagac
      901 ttctcaaaac gaagtcagaa agaagtcctt ttaaaatgag aaaccgcatt ttttcttttt
      961 ttcttttttt tctggttaag aaaaacagaa aaacgattaa gatttccttt ctgtcaactc
     1021 ttcagttacc aatttttggt aaagtttcgt ttaatcgttc tcacgtgcca cttcatgttt
     1081 aaatttttta tcacgtggta ctttaaagta agacttactt ggcttttgtt cttctggaaa
     1141 aaaatgttga gccgctttct ttctggctaa tattctttct gcaacggacc tggagcaggt
     1201 gcggcacgtg tgtgtgaaag ggacacagag ggacaaagac ggcctcactg tgaggaaaat
     1261 ttatatttgc agagaggctg gggaatgagc aaataaagag aaagaactga gtttgtatga
     1321 acaaagtttt ctagaatttg aatccaataa agcatatttg gatacta
//
LOCUS       NM_001436963            3219 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase like domain
            containing 2 (Tstd2), transcript variant 1, mRNA.
ACCESSION   NM_001436963 XM_006238088
VERSION     NM_001436963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006238088.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.22689.1,
                                           SRR26643294.21079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000005.1  65211224-65211292   c
            70-274              JAXUCZ010000005.1  65207932-65208136   c
            275-588             JAXUCZ010000005.1  65204444-65204757   c
            589-709             JAXUCZ010000005.1  65202357-65202477   c
            710-835             JAXUCZ010000005.1  65198348-65198473   c
            836-941             JAXUCZ010000005.1  65197553-65197658   c
            942-1060            JAXUCZ010000005.1  65194234-65194352   c
            1061-1219           JAXUCZ010000005.1  65193640-65193798   c
            1220-1358           JAXUCZ010000005.1  65192934-65193072   c
            1359-3219           JAXUCZ010000005.1  65188829-65190689   c
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="thiosulfate sulfurtransferase like domain
                     containing 2"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
     exon            1..69
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            70..274
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="upstream in-frame stop codon"
     CDS             110..1591
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="isoform a is encoded by transcript variant 1;
                     thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2; thiosulfate sulfurtransferase
                     (rhodanese)-like domain containing 2"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase/rhodanese-like
                     domain-containing protein 2 isoform a"
                     /protein_id="NP_001423892.1"
                     /db_xref="GeneID:362514"
                     /db_xref="RGD:1310893"
                     /translation="MPSPTSADEEDGLETCVLKTFDLDLKESNIVTPSNSLKAELDGS
                     TKKKYSFAKKKAFALFVKTKQVPVPSYEVKERRWRCCQQLFAEQTSIHRHVATQHAED
                     VYQQTASILKQLTAALRTPQSLTPTDRRSSPKDCLPPSQDVSAWLPDVSHVSPQELRS
                     GQGNEEGEVLLYYCYCDLEDPDWVCAWQAALCRHLHLTGKIRIATEGINGTVGGSKVA
                     TRLYMEVMLSCPLFKDYLSEDDFKSSKGGSHCFPELRVGVFEEIVPMGISPSEVSYKN
                     PGIHLSPGEFHKEIEKLLSQANQEQGDTLLLDCRNFYESKIGRFQGCLAPDIRKFSYF
                     PSYVDKNLDIFRQKRVLMYCTGGIRCERGSAYLRAKGVCKEVFQLKGGIHKYLEEFPD
                     GFFKGKLFVFDERFALAYNSAVVSECSYCGAPWDQYKLCSTPQCRQLVLTCSACQGQG
                     FTACCVMCQDKGGKQASDPTQDSFKEECECTARRPRIPQEQRA"
     misc_feature    614..1486
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    614..1486
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cl00125"
                     /db_xref="CDD:444705"
     misc_feature    1169..1171
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     misc_feature    1169..1171
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /note="active site residue [active]"
                     /db_xref="CDD:238776"
     exon            275..588
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            589..709
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            710..835
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            836..941
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1060
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1358
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..3219
                     /gene="Tstd2"
                     /gene_synonym="RGD1310893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggctcca gggcggggag cagcgccaag ttggagaagg gagacccagg aaaggcctag
       61 gtattgcgga tacttgactg aaagggatcc atcccactga taaaaccaga tgccttctcc
      121 cacttcagca gacgaagagg atggcctgga gacctgtgtt ttaaagactt ttgatctgga
      181 tttaaaagaa tcaaatattg ttactccaag caatagtctc aaagcagagt tagatggcag
      241 tacaaagaag aaatactcgt ttgcaaagaa aaaggccttt gccctttttg tcaaaaccaa
      301 acaagttcca gtgccttctt atgaagttaa ggaaagacgg tggcgatgtt gtcagcagct
      361 gtttgcagag cagaccagca tccacagaca tgtggccaca cagcacgctg aagacgtgta
      421 ccagcagact gcttccattc tcaagcagct cactgcagca ctgaggaccc cacagagtct
      481 tacgcccaca gaccggagga gctccccaaa agactgtctc cctcctagtc aggatgtgtc
      541 tgcttggctc cctgatgtga gccacgttag cccgcaagag ctgaggagtg gccagggcaa
      601 tgaggaagga gaggtgctcc tgtattactg ctactgtgac ttggaggacc ccgactgggt
      661 ctgtgcctgg caggcagctc tgtgccgtca cctgcacctt acaggcaaga ttcggatcgc
      721 gacagaagga atcaatggaa ccgttggagg aagcaaagtg gccacccgac tctacatgga
      781 agtcatgctt tcttgcccat tatttaagga ttacctgagc gaggatgatt ttaagagcag
      841 caaaggaggg tctcactgct tcccggaatt gcgagtcggt gtgttcgaag agatcgtgcc
      901 catggggatc agccccagtg aggtctccta caagaacccc ggaatccatt tatcccctgg
      961 agaatttcat aaagaaatag aaaaactatt gtcacaggca aatcaggaac aaggtgatac
     1021 tctcctactg gactgcagga acttctatga aagcaaaata ggacgattcc agggctgctt
     1081 agcaccagac atcaggaagt tcagttactt ccctagctac gttgacaaaa accttgacat
     1141 tttcaggcag aagagggtgc tgatgtactg cactgggggc attcgctgcg aacggggttc
     1201 tgcatacctc agagccaagg gagtgtgtaa ggaagtgttt cagctcaagg gtggcatcca
     1261 caagtatcta gaagagtttc ctgatggatt tttcaaaggg aagctgtttg tttttgatga
     1321 gcggtttgcc ctggcctaca acagtgctgt ggtctcagaa tgttcatatt gtggagcccc
     1381 gtgggaccaa tataaactct gttctactcc tcaatgccgc cagcttgtgt tgacctgttc
     1441 tgcctgtcaa ggacaaggat tcacagcctg ttgtgtcatg tgtcaagaca aagggggcaa
     1501 gcaggcttca gaccccaccc aggacagttt taaagaagag tgtgagtgca cagcccggag
     1561 gccacgcatt ccgcaggagc agcgtgcgtg accccctgag cctgggcccg gagcctgcgg
     1621 ctgctgaggc tgaactgctc gttcagcagt cactggcttc acgacgtaga gttacatagc
     1681 catgtgcaga tggtgaaggt tgtagaaaca aatggagagt gtccatgctg gtcactacca
     1741 ccctagcaga tagatggcca cagcaaagga ccaggaagtc cagcgtaggc tacctaattt
     1801 acctgctttg attgagaaga tgctagagcc tgggaaaagg taaaccatgt gggatcccag
     1861 tgttgatgag agattgtctt gagcttggtg gctcctcggc cgtgcagcag ggaggccccg
     1921 gcgccactct agtcccctgt actgtccata gccttacagt ttggtgtcag caaaccttca
     1981 ccctggcagc aaaagtataa aagttgggcc ctgggtatgg actcttaaac cagaccagct
     2041 tctatctccc cctgcctcat tctcttccct gactgcccga aggctctgtg gctttgacca
     2101 cctcgtgcct tggagcatta atgaatctgc caacccatcc ctttatatgt gatcatggca
     2161 ctactgagta gggccagaga ccacgtggcc ttcagaatct aaagcaatta cactttgttc
     2221 cttcacggag gtctttggaa agaggtggcc catgcttcta ttgattaggt ttctttaaag
     2281 atggtcttct aacagctctg cattccccag cagtccctct ctctgcttgt aagcatcctc
     2341 agggatccag atgagcagca ggcttacgtc acatgtggca cacaggacat tcattagtga
     2401 gctcatacag cacggtagcg acctaacctc ctggcctttg ggcacatgtt cctgtctcac
     2461 aattcttaag aagcacacag gccatacata caccaaatgg ctttaatatt attttgcagt
     2521 ttccagtgat gcagaatgca gctgcagttg tgtttcaagg agaagctgag tggagctggc
     2581 tgtccctgca gcttggtgcc actcctgggc ctcagtgacc actcacagtg ctgaggcccc
     2641 gatgccactc tagttaccct gtgctgtcca tggccttaca gtccggtgtg caggtcttag
     2701 gtcagaagcc cctggctgtg ctctgcagct tttgagccat cactgtcata tcggctgaat
     2761 ccctaaggaa aacactcccc aaagcaacaa aagtactagt ttaactggca ctgtggtcta
     2821 ttaaaaggca caagaacagt gtattttaac atttttactg gctcccatgg tgttaaaggg
     2881 atccagtagg aatgccaaga ttaggtttca gaataattcc ttgtgttgta tgtccaggat
     2941 ctcctaattc cttaccattg ggatgttgta ctctgctgtc cttcagaggc ttcgtgtgtg
     3001 atttgatttg tctcctaagt gaccgggcag gcacttggtg tctgtaagca gggccatgct
     3061 aaataccaca ggcatggtgg actggaaatt cacccaatgg tgttgatctc acataagccg
     3121 ttggctcact gcggtattgg aagatgtttt tatgtggttg taagttttca tccatcatga
     3181 agttggcatt caataaagaa gaaatgattt ctgactaca
//
LOCUS       NM_001106080            4436 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus transketolase-like 2 (Tktl2), mRNA.
ACCESSION   NM_001106080 XM_001073142 XM_224769
VERSION     NM_001106080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4436)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 26, 2025 this sequence version replaced NM_001106080.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360181.146874.1,
                                        SRR26360181.2908926.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4436              JAXUCZ010000016.1  27971884-27976319   c
FEATURES             Location/Qualifiers
     source          1..4436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4436
                     /gene="Tktl2"
                     /gene_synonym="RGD1304767"
                     /note="transketolase-like 2"
                     /db_xref="GeneID:290685"
                     /db_xref="RGD:1304767"
     exon            1..4436
                     /gene="Tktl2"
                     /gene_synonym="RGD1304767"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1913
                     /gene="Tktl2"
                     /gene_synonym="RGD1304767"
                     /EC_number="2.2.1.1"
                     /codon_start=1
                     /product="transketolase-like protein 2"
                     /protein_id="NP_001099550.1"
                     /db_xref="GeneID:290685"
                     /db_xref="RGD:1304767"
                     /translation="MALARDAKLESDIFQALQDVANRLRIHSIRATCASSSGHPTSCC
                     SAAEIMAVLFFHTMRYKQADPEHPDNDRFVLSKGHAAPILYAVWVEVGRICESDLLNL
                     RKIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYFDKASYRVFCLMGDGES
                     SEGSVWEALAFASHYKLDNLLAIFDVNRLGQSGTAPLEHCTDIYETRCQAFGWNTYVV
                     DGHDVEALCQAFWKAAQVKNKPTALIAKTFKGRGIPNVEDAENWHGKPMPKDRVDGIV
                     KLIESQIQTNRNLTPKPPVEDSPRISISNTKMTSLPAYKLGDMIATREAYGVALAKLG
                     HSNQRVIVLDGDTKNSTFSEVFKKEHPERFIECFIAEQNMVSVALGCATRGRTIAFVS
                     TFAAFLTRAFDQIRMGAISQTNVNFVGSHCGVSIGEDGPSQMALEDLAMFRSIPNCTI
                     FYPSDAVSTEHAIYLAANTKGMCFIRTTRPKLAVIYTSEENFVIGQAKVIRHSADDKV
                     TVVGAGVTLHEALEAADELSQQGISIRVIDPFTIKPLDASTIIQSAKATGGQIITVED
                     HYREGGIGEAVCAAISREPDIVVHQLAVTEVPRSGKPSELLDMFGISARHIIAAVKDT
                     VMK"
     misc_feature    78..1898
                     /gene="Tktl2"
                     /gene_synonym="RGD1304767"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
     misc_feature    78..1898
                     /gene="Tktl2"
                     /gene_synonym="RGD1304767"
                     /note="transketolase; Reviewed; Region: PRK05899"
                     /db_xref="CDD:235639"
ORIGIN      
        1 ggtcttccgc aggcgaccag cctgcagcca tggccttggc tagagatgcc aagctggagt
       61 cagacatctt tcaggcgctt caggatgtgg ccaatcgcct gcgaatccac tcaatcaggg
      121 ccacgtgtgc ctccagctcc ggacatccca catcgtgctg tagtgcggcc gagatcatgg
      181 ctgtgctctt cttccatacc atgaggtaca aacaggcaga cccagaacac ccggacaacg
      241 accgcttcgt cctctccaag ggccacgcgg cgcccatcct ctatgcggtt tgggtggagg
      301 tgggccgtat ctgtgaatcg gacttgctga acttgcgaaa aattcactgc gacctggagg
      361 gtcatcccac ccctcggcta tcgtttgtgg atgttgcaac agggtccctt gggcaaggac
      421 tgggtgctgc ctgcggaatg gcttacaccg gcaagtactt tgacaaggcc agctaccgcg
      481 tgttctgcct catgggggat ggtgagtcct ctgaaggttc tgtctgggag gccttggcct
      541 tcgcttccca ctacaagttg gacaatctcc tggcaatctt tgacgtgaac cgcctggggc
      601 aaagcggcac agcaccccta gagcactgta ccgacatcta cgagacgcgc tgccaagcgt
      661 ttgggtggaa tacttacgtg gtggatggtc acgatgttga agctctctgc caggcctttt
      721 ggaaagcagc tcaagtcaag aacaaaccta cggccctgat tgccaagacc ttcaagggca
      781 gaggtattcc aaatgtcgag gatgcggaaa attggcatgg aaagcctatg ccgaaagaca
      841 gagttgatgg aattgtcaaa ctaattgaaa gtcagataca gacaaaccga aatctcaccc
      901 cgaagccccc tgttgaagac tcaccccgga tcagcatatc caatacgaaa atgacctctc
      961 tgcctgctta caaactggga gacatgatag ctacccgaga agcctacggc gtggctctgg
     1021 ctaaattggg ccactctaac caaagagtta ttgttttaga tggcgacacg aaaaactcta
     1081 ccttttcgga ggtattcaag aaagagcacc ctgagcgttt catagagtgc ttcattgctg
     1141 agcaaaacat ggtaagtgtg gcactggggt gtgccacacg agggcgaact attgctttcg
     1201 ttagtacctt cgctgccttc ctgacccgag cctttgatca gatccgaatg ggagccatct
     1261 ctcaaaccaa cgtcaacttc gttggttccc actgcggggt gtctattgga gaagatggac
     1321 cttcccagat ggccctggag gatctagcca tgttcagaag catccccaac tgcactattt
     1381 tctatccaag cgatgctgtc tctacagaac acgccattta tctggcagcc aacaccaagg
     1441 ggatgtgctt cattcgtacc acccggccca aattagcggt tatttataca tccgaagaaa
     1501 attttgtgat tggacaggcc aaggtgatcc gccacagtgc agacgacaag gtgacagttg
     1561 ttggagcagg ggttactctg catgaagcct tagaggctgc tgacgagctt tctcaacaag
     1621 ggatttctat ccgtgtcatt gacccgttca ctatcaaacc tctggatgct tccaccatta
     1681 tccaaagtgc caaagccaca ggtggccaga tcatcaccgt ggaagatcac taccgagaag
     1741 gtggcattgg ggaggctgtg tgtgcggcca tctctagaga gcctgacatc gtcgttcatc
     1801 aacttgcagt aacagaagtg cctcgaagcg ggaaacctag tgaactactg gatatgtttg
     1861 gaatcagtgc cagacacatt atagcagctg tgaaagatac cgtaatgaaa tgaaatagcc
     1921 cacttcttca tacatcaagg ttgttggctt tggtcttaaa ctctgatatc tttgtgttac
     1981 atttatgctt gttataaaaa aaactatata gttctctttt tcaagtatca gtgtgtaaca
     2041 cttttatttc taataataag aaaaaaaaac ctgagctaac tttattgtta aattaacaaa
     2101 tgtcactctt gtgttttagt tgttatggtg aattatacat ttttaggttt caaatagaca
     2161 aaagcactta attacaaagt tttatgataa gattctaaat aatcagttgg gatggggata
     2221 atgcaaatat aactatcaaa tgtgtatagt tgctttttgt tttttggatt ttttttgttt
     2281 tttgaaaatt aagggaatgt ggattaaatt gtagacttga ttagctgaga ttccgaaggc
     2341 catttgagca cttgcatagt gacagtctat actagccttc tctcgccagg tgctacttga
     2401 ccggttactg tgggattctc tgcacagttc ctctgtcccg ttggtgggga catcactttg
     2461 agtaacactt ttctgtagtg aaatgaaggt gtggctactt ctagtttgtg ctttacatat
     2521 taatacagtg gtttgtggaa agggagagct tttttcttat gttaaccaaa ctacgttgtt
     2581 aattattttc atctgcggtg aataatagat gtgataaaaa gtttttagtg gagcagttta
     2641 ttgtctgttg tttgtaactg cgttctcggt gatcagtatg aacaggaaga aaatgtgtct
     2701 ctgactccta ggcaaggaaa agaagtcagg gctggaggta agtgtaggaa atgatagact
     2761 gaaaagaatt cttaatttta tcttcataat atctttgagg ttcgagataa aagttgcagt
     2821 caggaaaatt caaaaagaca gtgagttcag aggtggtgta acattttgaa ggtgcttgga
     2881 tgtgtcagag acctctctat tgttttcctc attaattatc tgcattgata atctttggag
     2941 gcctaaccga ttggttttcc agcaaggtgg aggtatgaca ggatacagaa aatactaacc
     3001 tgagaattgg aaacaccaag tcctggagtt tctacacggc cccatgatct aattgcctct
     3061 ctcaagataa ccattcctcc ttgcatgcca ttttaaaata gtttagaaaa aatagttgat
     3121 gtaagaacat tgtaaacttt agaaagggta gatgaggaga gcacttgcca ccttgcattt
     3181 cactccctcc caattcctac ctgcttggtg atctgtaact atgggcctgt taatagtccc
     3241 atctgaacct agtaccatca gataccacat ttcccagagt gtgggtgcta ttgcaggata
     3301 agtcccttcc tcatgctttc ttgcctcatg gggatacacg gttgatttac aaattgtaaa
     3361 ctagacaaaa tatgaaaaca aaattacatt ggttcctcca gcttttatta ttttagactg
     3421 tgtgaggact gtttttaacc aaatatgcaa atacatgcat ttaatagtga cagtacatct
     3481 gaaaatttta aatgtctaat ggaatcttgg tgactgcttg gtactgcttg gttctgtaga
     3541 agtgcgggga ggctcttaga ccatactgca aacaaaacac tgacttgggt ggcagatttt
     3601 ataatgagag tgggggtgag gcttaccaca tgctgagccg tccttaagca ggacagagtc
     3661 ttgttcggtt ttgctacata atgactgctc tgaagctctg aatctcttct gactaatatc
     3721 actcgctgct aaaattgaag acaaaagggt ttttcttctg gtttttcttt cataaaatga
     3781 ccaaaacatc tctgtttttc atgaaatttc actttataat ttaatgagtt aaattattct
     3841 tgagacaggc cttgctgtgg tagctcgcga tggcctcaaa cttgcactca tccgctggcc
     3901 tctgccatca gctggccttt acctgcccag tactgacatg aaagatgtat gccctatgcc
     3961 ctgtatagtt ttgttaagca ataaaacatg acagtggttc agtgccgata tgctatttaa
     4021 ggttttgcct caaagaaggt cttctcgatt atcaggaaag ctgagtgatg gttcagggat
     4081 ggctgtcaca tcacaattgc cttgcttatg gttggagtag aaaggccaat gagaaaatta
     4141 cactcattcc agtcaatgtc tgatttcttg agttgtgtgg aataagagtg taaaagaata
     4201 agagtggaat ttttagtcta ccttaaatac attgaaaagg tcatttaaat aaaagttcag
     4261 ttgagggatc tgtttgggga aaatagcctt ttaaagaaag ggcaaaagac ttggcattta
     4321 tgatgtcaag ataccagtgc tgggcctggt ccctggggcc cgtaatccca actagctttg
     4381 gaaaacatca ctgtacttca aaaataaact tgcatgtcat aagtttcaat gaaaaa
//
LOCUS       NM_001436739            2743 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus SRY-box transcription factor 17 (Sox17),
            transcript variant 1, mRNA.
ACCESSION   NM_001436739 XM_039109751
VERSION     NM_001436739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Walters,R., Vasilaki,E., Aman,J., Chen,C.N., Wu,Y., Liang,O.D.,
            Ashek,A., Dubois,O., Zhao,L., Sabrin,F., Cebola,I., Ferrer,J.,
            Morrell,N.W., Klinger,J.R., Wilkins,M.R., Zhao,L. and Rhodes,C.J.
  TITLE     SOX17 Enhancer Variants Disrupt Transcription Factor Binding And
            Enhancer Inactivity Drives Pulmonary Hypertension
  JOURNAL   Circulation 147 (21), 1606-1621 (2023)
   PUBMED   37066790
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Zou,X., Liu,T., Huang,Z., Zhou,W., Yuan,M., Zhao,H., Pan,Z.,
            Chen,P., Shao,Y., Hu,X., Zhang,S., Zheng,S., Zhang,Y. and Huang,P.
  TITLE     SOX17 is a Critical Factor in Maintaining Endothelial Function in
            Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner
  JOURNAL   Adv Sci (Weinh) 10 (14), e2206139 (2023)
   PUBMED   36919784
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Sangam,S., Sun,X., Schwantes-An,T.H., Yegambaram,M., Lu,Q., Shi,Y.,
            Cook,T., Fisher,A., Frump,A.L., Coleman,A., Sun,Y., Liang,S.,
            Crawford,H., Lutz,K.A., Maun,A.D., Pauciulo,M.W., Karnes,J.H.,
            Chaudhary,K.R., Stewart,D.J., Langlais,P.R., Jain,M., Alotaibi,M.,
            Lahm,T., Jin,Y., Gu,H., Tang,H., Nichols,W.C., Black,S.M. and
            Desai,A.A.
  TITLE     SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads
            of Sex, Metabolism, and Genetics
  JOURNAL   Am J Respir Crit Care Med 207 (8), 1055-1069 (2023)
   PUBMED   36913491
  REMARK    GeneRIF: SOX17 Deficiency Mediates Pulmonary Hypertension: At the
            Crossroads of Sex, Metabolism, and Genetics.
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Wan,Q., Liu,H., Xu,Y., Zhang,Q. and Tao,L.
  TITLE     Upregulated miR-194-5p suppresses retinal microvascular endothelial
            cell dysfunction and mitigates the symptoms of hypertensive
            retinopathy in mice by targeting SOX17 and VEGF signaling
  JOURNAL   Cell Cycle 22 (3), 331-346 (2023)
   PUBMED   36200131
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Park,C.S., Kim,S.H., Yang,H.Y., Kim,J.H., Schermuly,R.T., Cho,Y.S.,
            Kang,H., Park,J.H., Lee,E., Park,H., Yang,J.M., Noh,T.W., Lee,S.P.,
            Bae,S.S., Han,J., Ju,Y.S., Park,J.B. and Kim,I.
  TITLE     Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via
            HGF/c-Met Signaling
  JOURNAL   Circ Res 131 (10), 792-806 (2022)
   PUBMED   36205124
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Park,K.S., Wells,J.M., Zorn,A.M., Wert,S.E. and Whitsett,J.A.
  TITLE     Sox17 influences the differentiation of respiratory epithelial
            cells
  JOURNAL   Dev Biol 294 (1), 192-202 (2006)
   PUBMED   16574095
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Niimi,T., Hayashi,Y., Futaki,S. and Sekiguchi,K.
  TITLE     SOX7 and SOX17 regulate the parietal endoderm-specific enhancer
            activity of mouse laminin alpha1 gene
  JOURNAL   J Biol Chem 279 (36), 38055-38061 (2004)
   PUBMED   15220343
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Murakami,A., Shen,H., Ishida,S. and Dickson,C.
  TITLE     SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
  JOURNAL   J Biol Chem 279 (27), 28564-28573 (2004)
   PUBMED   15082719
REFERENCE   9  (bases 1 to 2743)
  AUTHORS   Kanai-Azuma,M., Kanai,Y., Gad,J.M., Tajima,Y., Taya,C.,
            Kurohmaru,M., Sanai,Y., Yonekawa,H., Yazaki,K., Tam,P.P. and
            Hayashi,Y.
  TITLE     Depletion of definitive gut endoderm in Sox17-null mutant mice
  JOURNAL   Development 129 (10), 2367-2379 (2002)
   PUBMED   11973269
REFERENCE   10 (bases 1 to 2743)
  AUTHORS   Kanai,Y., Kanai-Azuma,M., Noce,T., Saido,T.C., Shiroishi,T.,
            Hayashi,Y. and Yazaki,K.
  TITLE     Identification of two Sox17 messenger RNA isoforms, with and
            without the high mobility group box region, and their differential
            expression in mouse spermatogenesis
  JOURNAL   J Cell Biol 133 (3), 667-681 (1996)
   PUBMED   8636240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 20, 2025 this sequence version replaced XM_039109751.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.18615.1,
                                           SRR26643299.21868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  19814333-19814484
            153-343             JAXUCZ010000005.1  19814831-19815021
            344-634             JAXUCZ010000005.1  19815350-19815640
            635-1025            JAXUCZ010000005.1  19817312-19817702
            1026-2743           JAXUCZ010000005.1  19818140-19819857
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2743
                     /gene="Sox17"
                     /note="SRY-box transcription factor 17"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
     exon            1..152
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            153..343
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            344..634
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1025
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    689..691
                     /gene="Sox17"
                     /note="upstream in-frame stop codon"
     CDS             719..1990
                     /gene="Sox17"
                     /note="SRY-box containing gene 17; SRY (sex determining
                     region Y)-box 17; SRY box 17"
                     /codon_start=1
                     /product="transcription factor SOX-17"
                     /protein_id="NP_001423668.1"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
                     /translation="MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKV
                     KGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALA
                     EPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGAHYRDCQGLGAPALDGYP
                     LPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQVSDYAVPAEPSAGPMRVGPDP
                     SGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQPPPPPPPPPPPQQH
                     PTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEMGLPYQGHD
                     CGVNLSDSHGAISSVVSDASSAVYYCNYPDI"
     misc_feature    902..1144
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    902..1144
                     /gene="Sox17"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 17 (SOX17) and similar
                     proteins; Region: HMG-box_SoxF_SOX17; cd22047"
                     /db_xref="CDD:438850"
     misc_feature    order(923..928,932..937,941..946,956..958,965..967,
                     998..1006,1013..1018,1025..1027,1034..1036,1124..1129,
                     1133..1141)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    order(923..928,932..937,941..946,956..958,965..967,
                     998..1006,1013..1018,1025..1027,1034..1036,1124..1129,
                     1133..1141)
                     /gene="Sox17"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438850"
     misc_feature    1325..1477
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     misc_feature    1325..1477
                     /gene="Sox17"
                     /note="Sox 17/18 central domain; Region: Sox17_18_mid;
                     pfam12067"
                     /db_xref="CDD:463454"
     exon            1026..2743
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gataacgtcg cgaactcggc ttccaacacc catttagtga agaaactgaa acatggtcca
       61 ctcacaactg ctggcgggtc tgaagtgcgg ttgcccccaa cacttctccc aaagtatcta
      121 tcaagagaat ggtcagcaga aattagatct agctttcgga gaaatcaacc aagacagtga
      181 agacagagaa aatgcattct ggacccgcta ctgtttccaa ccttcatttc aaataaagcc
      241 catagtttat taaaaaaaaa attcacggaa agagaaaatt cggccctggg atctttaaaa
      301 agatgtcggt tactagatgc aaaagagaaa agtcactgtg gagcagattt aaatttaccc
      361 cctttgtatg aatcttaaga cctggaactt taaacactct cacggatctc tctgcacaac
      421 atccagcttt aaatgggagg gtcgccattg ctttataaca taacaaattc gagaaagaat
      481 ggcttctgta tgagttcttt ggagacaaga tagttccaga aactgcaggc caggagctag
      541 caaaacctct gtgcgttttg gaacctccag taagccagac ttggtatctg aaataacaca
      601 aggaaacctc agcatgttac ctcatgggcc acaagcaagc ttcccatccc cgcctcaggg
      661 tccggggaag cggcgtgtcc cgtggccgta gcagagcgcg gggtcggtct ggagcgccat
      721 gagcagcccg gatgcgggat acgccagtga cgaccagagc cagcctcgga gcgcgcagcc
      781 cgcggtgatg gccgggttgg gcccctgtcc ctgggccgag tccctgagct ctctcgggga
      841 cgtaaaggtg aaaggagagg tggtggcgag tagcggggcg ccagccggga cctcgagtcg
      901 agccaaagcc gagtctcgca tccggcggcc gatgaatgcc tttatggtgt gggccaaaga
      961 cgaacgcaag cggctggcac agcagaaccc ggatctgcac aacgcagagc tgagcaagat
     1021 gctaggcaaa tcctggaagg cgttgacctt ggcggagaag cggcccttcg tggaagaggc
     1081 cgagcggctg cgtgtgcagc acatgcagga ccatcccaac tacaagtacc ggccgcggcg
     1141 gcgcaagcag gtgaagcgca tgaaacgggt ggagggaggc ttcctgcacg ctctcgccga
     1201 gcctcaggcc ggcgcgcttg gtcccgaggg cggccgcgtg gccatggatg gcctgggtct
     1261 gcctttcccg gagccaggct atccggccgg cccgccgctg atgtccccgc acatgggcgc
     1321 ccactaccgt gactgccagg gactgggcgc acccgcgctc gacggctacc ctctgcccac
     1381 tccggacaca tccccgttgg atggcgtgga gcaggacccg gctttctttg ctgccccgct
     1441 gccaggggac tgcccggcgg ccggagccta cacgtatgct caggtctcgg actatgcggt
     1501 gcccgcagag ccgtccgctg gccccatgcg agtgggaccc gacccctccg gctctgcgat
     1561 gccggggatc ctggcgcccc ccagtgctct gcacctgtac tacggcgcga tgggctcgcc
     1621 cgcggcaagc gccgggcgcg gtttccacgc tcagccccag cagccactgc aaccgcagcc
     1681 accgccgcca ccaccaccgc ctccaccgcc gcagcagcac ccgacgcacg gtccggggca
     1741 gccttctcca cctcccgagg ctctgccctg ccgggatggc acggaaccca accagcccac
     1801 tgagctacta ggggaggtgg accgcacgga attcgaacag tatttgcact ttgtgtataa
     1861 gccggagatg ggtcttccct accagggaca cgactgcggt gtgaacctct cggacagcca
     1921 cggagccatt tcctccgtgg tgtccgacgc tagctcagcg gtctactact gcaactaccc
     1981 tgacatctga cggttgccga tttgacctgc gggccagaag cagtgttaca cacttcctgg
     2041 aagcgctaag gaaatcctta gcgtcacgct gttttgtttt taagttgcct tggcatataa
     2101 tttatggtaa tttattttgt ctgccacttg aacagttgaa gggctacatg agattctcat
     2161 ttcaaatgcc tcgaggggtt tgctccccac catcactgtc cagttttagc cagtttttaa
     2221 tatctcacca acttgatcca aagaaatttt gtcacgatct taaaaaaatc ctggaatctt
     2281 ttttaaaaaa atctctatca cattggtttt atcaaagtaa tttaaagatc aacagtaaat
     2341 attacacaat tagaagtgta tagttaattg taaactttct attttcttac aaaatttaag
     2401 aaaccctaaa tacaaacagt ggggtgttca gatgtgatat cgttgttctc ctacgaaaaa
     2461 aattctcaca gaatgaactt gctatgtaca ttccaaaata ttggtttcta aaaataatac
     2521 tgtaaatgtt tttaattctg tatactttaa taaggctgtt caaaaattct ggtttttttt
     2581 tttgtcatct tgatatctgc caaaagagct tttcagatat atctgttttc gtttgtgttt
     2641 tcttccaaat gtctttatcc ctttccccac aaaatttgcc tttaatcccc acatttttag
     2701 agtcagagaa actaatcaaa ataaaatttg ttgtgactgt taa
//
LOCUS       NM_001105995            3149 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus kelch-like family member 8 (Klhl8), transcript
            variant 1, mRNA.
ACCESSION   NM_001105995 XM_001065538 XM_213995
VERSION     NM_001105995.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3149)
  AUTHORS   Nam,S., Min,K., Hwang,H., Lee,H.O., Lee,J.H., Yoon,J., Lee,H.,
            Park,S. and Lee,J.
  TITLE     Control of rapsyn stability by the CUL-3-containing E3 ligase
            complex
  JOURNAL   J Biol Chem 284 (12), 8195-8206 (2009)
   PUBMED   19158078
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474022.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_213995.4, XM_001065538.1.
FEATURES             Location/Qualifiers
     source          1..3149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3149
                     /gene="Klhl8"
                     /note="kelch-like family member 8"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
     exon            1..133
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            134..501
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Klhl8"
                     /note="upstream in-frame stop codon"
     CDS             283..2148
                     /gene="Klhl8"
                     /note="kelch-like 8"
                     /codon_start=1
                     /product="kelch-like protein 8"
                     /protein_id="NP_001099465.1"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
                     /translation="MASESTNGKLARSHVTKGRRQQQQQQQVRSRSSVSECDGDDSFI
                     FEANEAWKDFHGSLLGFYENGELCDVTLKVGSKLISCHKLALACVIPYFRAMFLSEMS
                     EAKQALIEIRDFDGDAVEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY
                     MKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL
                     SSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPVDFLMGVVAKEQI
                     VKQNLKCRDLLDEARNYHLHLSSKPVPDFEYSVRTTPRKHTAGVLFCVGGRGGSGDPF
                     RSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTN
                     KWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMNTP
                     RGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHG
                     CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN
                     AYLNTVEAFDPVLNKWELVGPVSHCRAGAGVAVCDCLTSQIRDVGHGSTNVVDCM"
     misc_feature    439..798
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    439..798
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    463..1890
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    463..1890
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    1351..1482
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1351..1482
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1492..1626
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1492..1626
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1633..1770
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1633..1770
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1774..1911
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1774..1911
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1915..2043
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1915..2043
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1948..2085
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    1948..2085
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     exon            502..1050
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1237
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1381
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1493
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1662
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1822
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2024
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..3149
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctccgcg gagccgggca cgagcaagcg ggcgggcaag tgagcgcgtc cgccgagtgt
       61 cggagctggg ctggcgcggc gccggcacgg agcgggtgtg gcggctcggc ctgcgcggcg
      121 gccgcggaca gagcaaactg tctaatgaaa ttgaaggttt cgaaagatgt ctaaagctta
      181 gtggccacat ctatcgtctg tcttctgacc cttaaaaaaa aaaaaacaaa gaataaatgg
      241 gatgtttcag aagagagcta tttaaaagga agagtgttgc aaatggcttc agaatctacc
      301 aatgggaagc tagctaggag tcacgtgaca aaggggcggc gtcagcagca gcagcagcag
      361 caggtgagga gccggtcctc tgtcagcgag tgcgatggcg acgactcctt catcttcgaa
      421 gccaacgagg cctggaagga ctttcacggc tctctcctgg gcttctatga gaacggggag
      481 ctctgtgacg tcactctaaa ggtcggctcg aagctcatct cctgccacaa gctggcgctg
      541 gcttgtgtca tcccctactt cagagccatg tttctttctg aaatgtctga ggctaagcag
      601 gcgctgatcg agattcggga ctttgacggc gatgccgtgg aggacttggt gaagttcgtc
      661 tactcttcgc ggctcactct gacagtggac aacgtccagc ctctgctgta tgcagcgtgc
      721 atcctgcagg ttgaactggt ggccagagct tgctgcgaat acatgaagct acactttcat
      781 ccctccaact gcctggctgt gcgagccttt gcggagagtc acaaccgaac agacctaatg
      841 gacatggcgg accagtatgc gtgcgagcac tttactgaag tggtagagtg tgaggacttc
      901 gtgagcgtgt ccccacagca cctgcacaag ctcctctcct ccagcgacct caacatcgac
      961 agcgagaagc aggtctacag tgccgccatc aagtggcttc ttgccaaccc acagcatcac
     1021 cctaaatggc tggacgagac ccttgcccag gtccgtctgc cactcttgcc agtggatttc
     1081 ctcatgggcg ttgtggcaaa agagcagatt gtcaagcaaa atctgaaatg tagagaccta
     1141 ctggatgaag ccagaaatta ccaccttcat ttgagcagta aaccagttcc tgactttgag
     1201 tattcagtcc gaactacccc gaggaagcat actgctggtg tgctgttctg tgtgggtggt
     1261 cgaggtggat ctggtgaccc ctttcgtagt atcgaatgct attctatcaa cacaaacagc
     1321 tggttctttg gaccagaaat gaacagccgc aggaggcatg tgggcgtgat ctctgtggaa
     1381 gggaaagtgt atgccgtggg cggccatgat gggaacgagc acctaggcag catggagatg
     1441 tttgaccctc tcactaacaa atggatggtg aaggcatcga tgaacaccaa gaggcgagga
     1501 attgccttgg cctccttagg gggcccaata tatgcgattg gaggattaga tgacaacact
     1561 tgcttcagtg acgtggagag atacgacatt gaatctgacc agtggagtac ggtggcgcca
     1621 atgaacactc cccgtggagg tgtcggctct gtggctttaa tcaaccatgt ttacgcagtg
     1681 ggtggcaacg atggcgtagc ctccttgtcc agtgtggaaa ggtatcaccc gcatctggat
     1741 aagtgggtgg aggtgaagga gatgggccag cggagagccg gcaatggtgt tagtgagctt
     1801 cacggctgct tatacgttgt tggtggtttt gatgataatt cccctctgag ttcggttgag
     1861 cggtacgatc ctcggagcaa caagtgggac tatgtggcag cgctcaccac tcccaggggt
     1921 ggcgtaggga ttgcgacggt gatgggcaag atctttgcag tcggaggcca caacggcaat
     1981 gcctacctca acacagtgga ggcgttcgac cctgtgctga ataaatggga actggtcgga
     2041 cctgtgtctc actgccgagc tggtgccggt gtggccgtgt gtgactgctt aactagccag
     2101 atccgagacg taggtcatgg gtccactaac gtggttgact gtatgtgatt aagtcccagc
     2161 aacaaggata cagtgccatc tgatggacgg gaagacgagc ctttcaacat ggcgcatttg
     2221 attgtgacca cagctactgt ctttgagtgt cagctgttgt aagtaggtct gtgggctgac
     2281 ggtgagagct gctagtcaca gagtgaagtg agctgtttcc tgcctcagca gacagtgagt
     2341 aggctggaag cagcctgtca gcccattctt gcgctgagag acgtttcatg tagtgccaaa
     2401 ccttaaaata gctgtttatt ttgatgaata aaatgtaatt tattgagttt tatctgttct
     2461 ttttcctgaa gaaactaact tcaggcagta gatttttttc ccagaggaga gagaagtcca
     2521 ctcatcaaca tgagaacttg aggcctgctc ccttgaggat cactctacat ggtgctggtg
     2581 aatgtatgtc ttgctttttg tctccagatg gtgactttca gttcttgggt gtttatgaag
     2641 tagggaaaat gtttgtgtgt ttctgagaca ttcttgaaac cacattagtg tctgtaagaa
     2701 ggccttggcc tccatgtgga gttttagaac cacaggacat agctgtgcct gcttcctcac
     2761 caagtgtact ggccgccatt cttttcccat tcgtgagagt ttcttggtga tgaccgtggc
     2821 ttggcatgag tgcagcgtcc agtgaaaaga ctgagaagga tgtatgaagc ccatgcccac
     2881 ctagggaggt tgtggaggct cctttaacct tgttcttctg cttagtcgtt gaatttggaa
     2941 ccaggaccca ttttctctta ctctgtcatt tgtcgccgtc ttgggtttcc taattgtaca
     3001 aagctgaatt tatttattat caggacatga atgcgttttt acaacattcc tttctgcagt
     3061 atagtctgat gattagttcc agtttgtcat taatcaataa aatatgttgc tggtaaaaac
     3121 agaaaaaaaa tgtaaactgc tagtttttt
//
LOCUS       NM_001135756            6242 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus polypeptide
            N-acetylgalactosaminyltransferase-like 6 (Galntl6), transcript
            variant 1, mRNA.
ACCESSION   NM_001135756 XM_017600182 XM_341429
VERSION     NM_001135756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6242)
  AUTHORS   Zhang,S., Wang,X., Chen,G., Tong,L., Dai,T., Wang,L., Zhu,L.,
            Zhang,H. and Du,D.
  TITLE     CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced
            hypertension through upregulating Lig3 in rostral ventrolateral
            medulla
  JOURNAL   Redox Biol 64, 102782 (2023)
   PUBMED   37315345
  REMARK    GeneRIF: CircRNA Galntl6 sponges miR-335 to ameliorate
            stress-induced hypertension through upregulating Lig3 in rostral
            ventrolateral medulla.
REFERENCE   2  (bases 1 to 6242)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003. PMID: 25715345]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 17, 2025 this sequence version replaced
            XM_017600182.3, NM_001135756.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2139697.1,
                                           SRR26643298.71383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1228              JAXUCZ010000016.1  36203416-36204643
            1229-1535           JAXUCZ010000016.1  36205066-36205372
            1536-1644           JAXUCZ010000016.1  36643590-36643698
            1645-1783           JAXUCZ010000016.1  36732375-36732513
            1784-1950           JAXUCZ010000016.1  36772016-36772182
            1951-2136           JAXUCZ010000016.1  37231236-37231421
            2137-2320           JAXUCZ010000016.1  37235180-37235363
            2321-2438           JAXUCZ010000016.1  37313228-37313345
            2439-2546           JAXUCZ010000016.1  37354251-37354358
            2547-2768           JAXUCZ010000016.1  37384920-37385141
            2769-2885           JAXUCZ010000016.1  37424509-37424625
            2886-3035           JAXUCZ010000016.1  37434326-37434475
            3036-6242           JAXUCZ010000016.1  37451503-37454709
FEATURES             Location/Qualifiers
     source          1..6242
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12-p11"
     gene            1..6242
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="polypeptide N-acetylgalactosaminyltransferase-like
                     6"
                     /db_xref="GeneID:361142"
                     /db_xref="RGD:1564773"
     exon            1..1228
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1050..1052
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="upstream in-frame stop codon"
     exon            1229..1535
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     CDS             1398..3203
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /EC_number="2.4.1.41"
                     /note="polypeptide N-acetylgalactosaminyltransferase 17;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 6"
                     /codon_start=1
                     /product="polypeptide
                     N-acetylgalactosaminyltransferase-like 6"
                     /protein_id="NP_001129228.1"
                     /db_xref="GeneID:361142"
                     /db_xref="RGD:1564773"
                     /translation="MKRKQKRFLQMTLLFTVALIFLPNIGLWSLYKDKHLMKSAEPAE
                     HQTFPLGLGDGQFYSWTDGLRRKDWHDYVSIQKDALRSGKGEHGKPYPLTEEDHDDSA
                     YRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTI
                     HSIINRTPESLIAEIILVDDFSDREHLKDKLEDYMARFPIVRIVRTKKREGLIRTRLL
                     GASVARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHSHFGYEAQAG
                     DAMRGAFDWEMYYKRIPIPPELQRADPSEPFESPVMAGGLFAVDRKWFWELGGYDPGL
                     EIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETW
                     MDEFAEYIYQRRPEYRHLSTGDISAQKELRKRLKCKDFKWFMAAVAWDVPKYYPPVEP
                     LPAAWGEIRNVAANLCVDSKHGAMGTELRLDICVKDGSERTWSHEQLFTFGWREDIRP
                     GEPLHTRKFCLDAISHSSPVTLYDCHGMKGNQLWGYREDRTLFHPVSNSCMDCNPAEK
                     KVFMARCDPLSETQQWMFEHINMTVLEKISHYAIS"
     misc_feature    1824..2711
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; Region: pp-GalNAc-T; cd02510"
                     /db_xref="CDD:133004"
     misc_feature    1824..2711
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; Region: pp-GalNAc-T; cd02510"
                     /db_xref="CDD:133004"
     misc_feature    order(1836..1844,1848..1850,1935..1937,2022..2024,
                     2031..2033,2043..2045,2091..2099,2337..2342,2406..2411,
                     2415..2417,2490..2492,2499..2501,2514..2516)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(1836..1844,1848..1850,1935..1937,2022..2024,
                     2031..2033,2043..2045,2091..2099,2337..2342,2406..2411,
                     2415..2417,2490..2492,2499..2501,2514..2516)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(2091..2093,2097..2099,2490..2492)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    order(2091..2093,2097..2099,2490..2492)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     misc_feature    2742..3179
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide
                     N-acetylgalactosaminyltransferase-like 6 (GALNTL6) and
                     similar proteins; Region: beta-trefoil_Ricin_GALNTL6;
                     cd23477"
                     /db_xref="CDD:467355"
     misc_feature    2742..3179
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide
                     N-acetylgalactosaminyltransferase-like 6 (GALNTL6) and
                     similar proteins; Region: beta-trefoil_Ricin_GALNTL6;
                     cd23477"
                     /db_xref="CDD:467355"
     misc_feature    order(2955..2957,2988..2990,2997..2999,3009..3014)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="putative sugar binding site [chemical binding];
                     other site"
                     /db_xref="CDD:467355"
     misc_feature    order(2955..2957,2988..2990,2997..2999,3009..3014)
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /note="putative sugar binding site [chemical binding];
                     other site"
                     /db_xref="CDD:467355"
     exon            1536..1644
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1783
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1950
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2136
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2320
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2438
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2546
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2768
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2885
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3035
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..6242
                     /gene="Galntl6"
                     /gene_synonym="Galnt17; RGD1564773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaccggc agacctctca gctataagca gcaggaggtg caggcatgct agggcgggga
       61 agcatcagtt agtgaagcca aagcttaacc tgggccccag gtgctggcgg actccagcgg
      121 agctgcctct gctctccact gtgttgtctg gaagctgcgg ctagcaaatc ggtccacgcg
      181 tggggatcct cttcctctct ccacgctacg tacctggctt gagctgtagg ttctggggga
      241 accctcctct cagggaccag tccagactgg gttgcctctg ctcactgtcg ctgccgctgc
      301 cgctgccgcg cctgcctcgc tgcgatctga tcaggaccat ggaggaattc ttccattgcc
      361 ctcccactcg gggcgactta gactctggaa tttctggcct ggcgcctttc gggtgagctc
      421 agagatgaac cggtctgcct accagttcga gattacccga gaagagagga tccgattgtc
      481 ccggagctgc aaatccattt ctccttctct gctttcatcc tcctttcctt ccccctagcc
      541 tccaggtttg tttatatagc acctggcagc cgggaggcag tggccactac cttcctgccg
      601 cggctcgccc acccctcccg gcctctaggc tcccgcacgt ggtagacacc agtatcgtcg
      661 ccagcaggca ggagacagcc agcgggaggc ggccgcctgg gtgccagctc cacgcgcgtt
      721 ctcgccatcc tcactcatcc tcagcgcgca ctctcccact tgcctgtaaa gccctgtcac
      781 acttgacatt cgccgcctgc catccgtccc ttgacgcgaa gtggagatcg gaaatacagc
      841 cctgggggtg ctggtgatgc ttcgctgggt tcgttcagtt gctggaaaag aatggtaaca
      901 tgaacagtgg agcgtgagag cgtcggcaca ggaaggggac tagattgatg ggcagagaac
      961 acacttctct gaggatctca ttcccaggac tgcgcgagga agggacatct ttgcgcctac
     1021 acttcctggc tggactctgc tgacatctgt agcctccttt ctgccaggtt cccaggtcgc
     1081 ctagatgctg cctgcagcgg agtgttctga cagcgcatga ggatccagga gtttgtgaac
     1141 ccctatccaa actagttctg acctggttat ggtgtccctg gatcctgagt gacaagctga
     1201 ctccagaggg agttgaactt gagttcagat ggccaactcc ctctgaaccc tgcagattgg
     1261 tgctgagcac acaacaaaag tttgtagctt cccctcagtt tctggtgctt cccgggaaag
     1321 aggaaaggac tttggcatta aacacaagaa gcagtctggg agtcatctct aacttttctc
     1381 cactgttatc atttgcaatg aagaggaaac agaaaaggtt tctgcaaatg actttgttat
     1441 tcactgtggc tttaattttc ctgcccaaca ttggtctctg gtctttgtac aaggataaac
     1501 atctgatgaa atctgcagaa cccgcggaac atcagacatt tccactgggc ctaggcgatg
     1561 ggcaattcta ttcctggaca gatggtctga gaagaaaaga ctggcatgac tatgtgagca
     1621 ttcagaaaga tgctttgcgc tcagggaaag gtgagcatgg aaaaccatac ccccttactg
     1681 aagaggacca tgatgactca gcttacaggg aaaatggctt caatattttt gtcagcaaca
     1741 atattgctct agagaggtct ctgccagaca tccgccatgc taactgtaag cacaagatgt
     1801 accttgaaag gctgccaaac accagcatca ttatcccatt tcacaatgaa ggctggacct
     1861 cactcttgcg gaccatacac agtataatca accggacacc ggagagtctg atagcagaaa
     1921 taattctagt cgatgacttc agtgatagag aacacttgaa agataaatta gaagattaca
     1981 tggctcgatt tcccatagtg agaattgtgc gcaccaagaa aagggaggga ctcatccgga
     2041 cccgactcct gggagcttct gtggccagag gcgaggtgct gaccttcctg gactcccatt
     2101 gtgaggtcaa tgtgaactgg ctgccccctc tcctcaacca aattgcacta aaccacaaaa
     2161 ccatcgtgtg tcccatgatc gatgtcattg accacagtca ctttgggtac gaggcacaag
     2221 ctggggatgc catgcgagga gccttcgact gggaaatgta ctacaaaaga atccccatcc
     2281 ctccagagct ccagcgggct gatcccagcg agccttttga gtctcctgtt atggctggag
     2341 gtctctttgc agtggatcga aagtggtttt gggaactggg tggctatgac ccaggcttag
     2401 aaatctgggg aggagagcag tatgaaatct cttttaaggt ttggatgtgc ggaggagaaa
     2461 tgttcgatgt tccatgttct agagtcggtc atatctacag gaagtatgtc ccttataaag
     2521 ttccgtctgg gactagcctg gcaaggaacc tgaagcgcgt ggctgagacc tggatggatg
     2581 aatttgctga gtacatttac cagcggcggc cagagtacag gcacctctcc accggagaca
     2641 tctctgccca gaaggagttg cggaaacgac ttaagtgcaa agacttcaaa tggttcatgg
     2701 ctgcggtggc ctgggatgtg ccgaagtact accctccggt cgagcccctg cctgcggcat
     2761 ggggtgagat tcgaaatgtg gcagcaaact tatgtgtgga tagcaagcat ggagccatgg
     2821 ggaccgaact gaggctggac atctgtgtga aggatggttc cgaaaggaca tggtctcacg
     2881 aacagctctt tactttcggg tggagagaag atattcgacc tggtgagcct ctgcacaccc
     2941 gaaaattctg cttggatgcc atctcacaca gcagccctgt caccctctac gactgtcacg
     3001 gcatgaaagg caaccagctc tggggatacc gggaggacag aacattattc catcccgtga
     3061 gcaacagctg tatggactgc aaccctgcag agaagaaggt tttcatggcc agatgtgacc
     3121 ctctgtccga gactcagcag tggatgtttg aacacatcaa catgactgtt ttagaaaaaa
     3181 ttagccatta tgccatctcc tagaaaagaa agaagagcga ttacctacag gttgtgaact
     3241 gtgttgttgc aggcatctgg atcaaaggag tcaggaataa catttcctag atccaggaag
     3301 cctggttgaa agacgtgtga aggccatgtt gacgtaggct gtccgggaga agttcctgca
     3361 tctgaagaac ttggctgaga tcctcaccag ctgcttctga gaactgagac tagcagttcc
     3421 cttgctggcc aagggtaaag attacttagg aactttcacc tcgactgctg agttaatcaa
     3481 ccctagcatt tctcaggtca aatcctgcag tagtgagtag ctatgaatgg atcctattaa
     3541 tcgggtggga ggggggtgga aacagagcgc atgactgctc tggcaacctg aggctaccac
     3601 aggtctagaa ctagccacgc ttaaggggtg agctgtactc tttggtgcca ttctctaaga
     3661 gtgggttaag caggtttaac cctttcaagt gctgcagatg attttagagt gctcatgcca
     3721 tttttctctt tccttttgtc ttctctttaa acaagggtac atgacgttga aaacttacac
     3781 tacatactct catctacaca tactcttttc cttcaaaggc ccatgttatc tgtcatggtt
     3841 cattagagct catggttcac caattagctg aagttctaat ccagtgacct tagatgaatc
     3901 cagttagaaa caaaaacaga ccaacaaaac ctatgctacc aggttactcc aaagaaagat
     3961 ttcacataag caacaaaata tcccaagcac ccacacacat acacacacac acacacacac
     4021 acacacacac atacactcac acacactcac acacacgcac actcacacac acacacatac
     4081 acacatacac tcacacacat acacatacag tcacacacac atacacacac acacaacatg
     4141 cacacaagtt agggcagaaa tttccctggg aaatctattt ttacttttct attattttta
     4201 aataaaaatc tgatgtttgt ccagtcataa tttttattaa agaaggtatt ggagtgggct
     4261 ccatgtaatt tgtttagtct atcttaaata aatcttcact ccaagtgatg tggaaatggc
     4321 ctcattcact ttaattctgt ttaattgggg aactttaaga gtggtgttat ttaatgatta
     4381 gttttgaagc ccctccctct tatggataat aatggtattg ttttattcag aagcccaaaa
     4441 agggattaca tttctgatgc cattttctgt taatggataa tatttcaggg gtatcaaaaa
     4501 gagaagtaac ttcaaaacta actaaattag atatttaaac cttaaaataa attttccctt
     4561 ttccataatg atggagtgag gagaagaaag tgcaggaatg aagatccatc tttagagggg
     4621 aaaaccacac ttgctatata gtctctactt gtgagtccag cttgttccta cattgctttt
     4681 actgcctttt gagatcgttt ccttgttaat aaaaatatat acattgagat gatctatgta
     4741 ttttggacat agatcactga agttccagga caggaagatg cagaagagtc taccttttct
     4801 gttgttgttc attttgtttc tcttgtttac tctgttttta aagtaagtat gaaaagtcca
     4861 gagaggccca gcttctggtg ggctcatcac ctggacgcct cactcctgtc cttccctcag
     4921 atgcccaatt attcagaagc ctagtatatg acatatcttc tagaaaatgt gcaagatcat
     4981 tttctgtcct ctaaccctaa tcaaaacata cattagacga ccctgctaag aattggggaa
     5041 ggattacgtc agtatcttta ctgataattt tttcaagcat tcttccaaaa agctgttctt
     5101 aaacagactg tcactgagat cttttgtgta tgtcaagtga tcttgacaca gttaagatgc
     5161 atagtggaga aaatcaataa tgagaaatta tcctgtgtgc agaacatctc taaggagtga
     5221 agaaggattt atctcagatg ttccgagacc aatctgactg gagacacaga tgattctata
     5281 aaaactcaca ttatgtcatt aaacaattga ttgctactta caattgtacc aaagacacac
     5341 cctgggttgc gcaccctgga ggcacagatt tgtagtaatc tcttaggatg cgatagttat
     5401 ggctaactca ccaggcccta ccctaagtgc tacagcattt tagagaggta cacagtgatc
     5461 aatctatatt aaacagtatt taaaaaatat ttttttcttt aaacacagaa tgaaagcttg
     5521 ggacattaaa tccgaaattg aaacttcgaa ctcggggcca gtcgttaatt gtgtgcacag
     5581 tgggaatgta cggatgaggt ggagcctggg gagtctgccc ctaggagggg agggcagagc
     5641 cctgcccagt aaagcacatt ggaaaaggtg tttcctatac cactggaggg caagcttcca
     5701 cttgcttgaa atacacaatc tgaaaagcat aaaactatgt aggtttgcac tttcaattag
     5761 caagagggat agaagagtcc tcagaaagac tattgttcgt gggagtaaaa ttctttgaag
     5821 agttcgatgg tagcgcccat atattctttc ctcagaatga ggggtgatat aaagttaatg
     5881 catcacagac tttgctattt ctccatcata agagacagtt ctggtggaag taagagaata
     5941 attaatttta aaaacccttt catgtattta cagtggaaaa aaatgatgct gtaacatgat
     6001 gtttcatgtt gggaactaag agtatgattc atcctttttc aaggctggag gagaaccttg
     6061 gcaataatga tataccggct tctgtgtctg ctgttattta cggataggaa ttgaatcaca
     6121 tgactgtttt taaatgtatt cattctatca gaagccccag tgaataatgc aagctctagg
     6181 actattttgt gaattgataa catagaactt tatacaataa atgaataaca cataatgcaa
     6241 aa
//
LOCUS       NM_001107326            6828 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus kelch repeat and BTB domain containing 11
            (Kbtbd11), transcript variant 1, mRNA.
ACCESSION   NM_001107326 XM_001074785 XM_006253392 XM_240482
VERSION     NM_001107326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Mar 17, 2025 this sequence version replaced
            XM_006253392.5, NM_001107326.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.72145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840113
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000016.1  81339769-81340020   c
            253-6828            JAXUCZ010000016.1  81318596-81325171   c
FEATURES             Location/Qualifiers
     source          1..6828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6828
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB domain containing 11"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
     exon            1..252
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     exon            253..6828
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    862..864
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="upstream in-frame stop codon"
     CDS             976..2877
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="kelch repeat and BTB (POZ) domain containing 11"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     11"
                     /protein_id="NP_001100796.1"
                     /db_xref="GeneID:306617"
                     /db_xref="RGD:1563576"
                     /translation="MENSVAPFVLYPGTEPRTPGEDSLPLPAEEEGAASPAQTPCSLS
                     ASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPQECARP
                     EEPASPEEPPSRREHARPVELESLDELGEPVPVPPGVGSEHGEPDLVIEVAGRRLRAH
                     KAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGCMAGVRPDNVAEVVAGAR
                     RLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLSELRDAAYRFMCDHYLEVLREP
                     AVFGRLSGAERDLLLRRRLGTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVY
                     CYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFVAGGVAPAGPDGRARPSDQVFCYN
                     PVTDCWSTVRPLRQARSQVQLLALDGHLYALGGECLLSVERYDPRADRWTAVAPLPRG
                     AFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFL
                     YRFDLCGSRGDAQAATGSGGGVSVFRYHCLAKQWSQCAAHLRPPGAPAGLQPFRCVAL
                     DGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEK
                     PDRGEQGAA"
     misc_feature    1405..1713
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1405..1713
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; Region:
                     BTB_POZ; cl38908"
                     /db_xref="CDD:453885"
     misc_feature    1684..1914
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1684..1914
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="BACK (BTB and C-terminal Kelch) domain; Region:
                     BACK; cl28903"
                     /db_xref="CDD:475122"
     misc_feature    1996..2697
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1996..2697
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    2041..2187
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2041..2187
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2197..2319
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2197..2319
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2461..2613
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2461..2613
                     /gene="Kbtbd11"
                     /gene_synonym="RGD1563576"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
ORIGIN      
        1 gcacgagatc cgcggaggac tggctcagct gcagccctaa ccgacggacc tccaagcccg
       61 aggtggcggg cagggaccgc gaggtgcacg cgcgcccggg ccgtgggccg cctcccagct
      121 cgcgcttcct ccaagcgcag ggcacacgca ggagtaatcg gctgctgcca acccagtggt
      181 tggcgcgcgt gcggaggagc ccggcgcgct cccggcattg ggaaagcgcg cagcatctca
      241 gcgctcgcac aggagcaagg aggtggagag tgatgtgggg acctgacggg gaaggaagca
      301 gcggaggctc ccgatgacaa atgaggaaaa cctgggtaca cacacagacg cttcctttcc
      361 agccattcac ccataggtgg agtgcttccc taggtggaca gtgtgggtgg gaagctgcca
      421 cccagacaca catctcagct ggattctcgg ctgcacagcg ggagtctgta gaacagagcg
      481 gaagctaagg atttaagtgt ggccaccgcc cctggaagat ttgctggtcc tgggtctaca
      541 gtactgtgat aggaggtgac tcagtgggtc cacccagagt ccaaggacgc ccatgcttgt
      601 ggcccagaca cacttaacct cagttctcca aaggagcaat acaaaggagc ctcagctccg
      661 agcagtcgat gtgtaaactg caaaaaaaca aagcaaaaac caaacccctc tttgccacca
      721 ggctaattga cctccgcccc acggacgtag cctgagttga agttcccctt tcgaaagttc
      781 agtgagagtt ggggcgttga gaggagagtg ggaagggcaa ggtgggagtg gcgtgaacag
      841 ggggtggaca catgtgaaat ctgatccggt gccaaggaaa gggtttgtgc tgccagagac
      901 cccagggcaa agctctacct ccaccgggca tgtgtggctc ctgagctggc cgactgcaca
      961 cgacacaacc cactcatgga gaactcggtg gcgcctttcg tcctctaccc ggggactgag
     1021 cccaggactc cgggagagga cagcctgcct ctgccagccg aggaagaggg cgctgcatcc
     1081 ccagcgcaga caccctgcag tctaagcgcc tcgctgtgtt tcagctccgg ggacgactcc
     1141 ccgccgcagt ctcgcgcctc tgccgcggag ggctccgaag cttctccgcc ttctctccgc
     1201 agcgacctgc gtgtggtgga gacgcagtgg gatgtcagca gcgcggcgtc cccagagtcc
     1261 ccacaggagt gcgcgcgccc ggaagagccc gcgtcgccgg aggagccccc ttcccgccgc
     1321 gagcacgcgc gtcccgtgga gctcgagtct ttagacgagc ttggggagcc cgtgcctgtg
     1381 ccgcccgggg tcgggtcaga gcacggagag cccgacttgg tcatcgaggt ggcaggtcgc
     1441 cggttgcggg ctcataaggc ggtgttggcg gcgcgcagcg actacttccg cgcgcgtgcg
     1501 tcgcgggacg tgctgcgggt gcaaggcgtg agcttcactg ccctgcggct gctgctggcc
     1561 gacgcgtaca gcgggtgcat ggccggcgtg cgaccggaca acgtggccga ggtggtggcc
     1621 ggcgcgcgcc gcctccagct gcccggcgct gcgcagcgcg ccaccgaggc catggcgccg
     1681 cagctgagcc tggacaactg ctacgaggtg ctgagcgcag gcaagcggca gcggctgagc
     1741 gagctgcgcg acgccgccta ccgcttcatg tgcgaccact atctggaggt gctgcgcgag
     1801 ccggccgtct tcggccgcct gtccggtgca gagcgtgatc tgctgctgcg gcgccgcctg
     1861 ggtacgggcc gcgcctgtct gctggccgct gccctgggga caaccgggga gcgctcgggc
     1921 agtcgaccgc agagtccgtc cggggacgca gagtcgcgcg gggacgcagc ggtttattgc
     1981 taccaggcgg aggccgggga gtggcgagag ctgactcggc tgcccgaggg cgcgcccgcg
     2041 cgcggctgcg gactctgcgt gctcttcaac tacctcttcg tggcgggcgg tgtggctcct
     2101 gcgggtccgg atggccgcgc gcgcccgtcg gaccaggtgt tttgttacaa cccggtcacc
     2161 gactgctgga gtactgtgcg acccctgcgc caggcgcgct cgcaagtgca gctgctggct
     2221 ctggacggcc acctatatgc cttgggcggc gagtgcctgc tcagcgtgga gcgctatgac
     2281 cctcgagctg accgctggac cgcggtggcc ccgcttcccc ggggcgcctt cgcagtggcc
     2341 cacgaggctg ccacctgtaa cggcgagatc tatgtgtccg ggggctcact cttctaccgc
     2401 ctgctcaagt acgatccccg gcgcgatgag tggcaggagt gcccatgcag cagcagccga
     2461 gagcgctctg ccgacatggt ggccctcgac ggtttcctct atcgctttga cctgtgtggg
     2521 agccgcggtg acgctcaggc tgcaactggt tcaggtggtg gggtcagcgt gttccgctac
     2581 cattgcctgg ccaagcagtg gagccagtgt gctgcacacc tgcggccccc cggcgcaccc
     2641 gcaggcctgc agccctttcg ttgtgttgcc ctggatggta ccatctactg tgtgagccgc
     2701 gctgggacct ggcgtttcgt gccttctcag gacactgagg ctggcagcga tatgggaccc
     2761 ggtggcagtt ttgaacctga gcccctggga tccccgctgg atgtccgggg cgtactcttt
     2821 ccatttgtgc tcaacctgcc tgagaagccg gaccgtgggg aacagggtgc ggcctaggac
     2881 aggatcagct gggcagctcc actgtccagc acttgtggtg gtggggggct ccaaagaatg
     2941 ggctgggccc cacccccagt aggggaggga gggcaaagag gtctcaggaa tggaggacgc
     3001 gcacaggcca ggctgctggc cacactgcat cgtgcaaacg ctttgagagt agaagcttca
     3061 actggcgctg aagacatttt tgcaatgctg ttttaagccc cgctttgcag tgctggattc
     3121 tgcttttgct tcgcttgttc gggggggggg ggtgtcatag cttaaagtgt gggaagatag
     3181 atacagagaa gcccatacct aagggaagaa gtagaggagg ccaggataaa gtgggacgca
     3241 ggtgcagact cgggtataat gaggaacctg cccagtcccc tccttaccag cgagtgcaag
     3301 gttctcaaac ctgaatgggg tcctaaagta ggccaggtat ccttgcaaac cacagagaga
     3361 cggtcaaacc ccgctctgag gtttaagtcg ataacttaga agatctgcac gacctaacca
     3421 ggacctaaaa agttcaccgt gtgttcgcaa gtaggttcaa cttcaaacag taacttctca
     3481 aatactgaag gcaaagggta gttgaccagt agagttgccg ttgttgctga ctgaacggaa
     3541 aagaacctca ggtcaggaga ccctggtagt tctgcatgtt cacccccttt cccgtcttag
     3601 aatgaaccag ggagattttt ttttccttcc tagaacagga ggttaaaatc atgttttgac
     3661 agttgcatgc tttgaaccct ctgctcggtt gttttgaacg tatcttctgt gattctgaag
     3721 agggagatta atttacaacc acctcaaaga aagtgtatgt gtgtatgggg tggggggtga
     3781 tatgctatgg aggaggaaaa ggagaaacgc accgttttga gtgtagttta gcaagcaagt
     3841 ggcattcatt taacttccta aacaccctac tcgagtccaa aggagactca gacttaggtt
     3901 gcaggaccaa aaccaagtcc gttcattttc tctcatgtgt tgggctgttg tgcttttgag
     3961 aatatacagg caaggatccc tgtttaaaga acagaatgtg tgctcccagg taactggttt
     4021 agattccata cctaaccctg ctgttttata acagtggggg tcctaagtat tcatcgtttc
     4081 tggaacataa gaggtagccc cgtgttcacc gtgccatctc tgtagaaatc actggttagc
     4141 tgagaaccag gctacacttt atagtctgtt ctgaaaggtc acggtgaagt gtgtttagaa
     4201 acagccagct tgaatcttct gcatgaccca ggggaatgga gtttatagtt cctgtttgta
     4261 tgttctggtc tctttgtgct tgttcgtggt tactcataaa ccaagagaat gtcttggcca
     4321 cttggttaat catcttaaga aaaacagact tcctattgcc tggttttatt ggtccttttt
     4381 gaggggcgtc ctggggaaag gcttgcagat gagccaaggg agccggtgcc tagagacaca
     4441 ccttcatcgc tgaagtacca gacttacaga atactgccac gtgacgtttg cctaagaagc
     4501 cgttcctctg acattcactt ttgaaattgg tcctctaggg tgacatgtcc ccagagaggg
     4561 cagatgtaca ccagacagga gagtcttcct gtgggcatag tgccccacag agcacaaaca
     4621 aaccccaagg aagtcaaaag gattaatgta cttacttgca gatcgtgaaa ggacattagt
     4681 tcgtcgatca cgaatagagg ccctgctttt tgagaactta taaagtatct tgtgtcctgt
     4741 ttataaacag tgacccccac tgaaaacaaa tgctacaggc cttggcacat ctcagcaacc
     4801 atgcattttg ttcctgggat ctggaagact tactacccat ctgtcttaga ttcactttcc
     4861 gtgataaaaa gcaacttaag ggagagaggt ttcattctgg ctcagagttt gggttacagc
     4921 ccttcatact gtggaagtcc cagggcaggg ctgtgagggg gcgggtgctt ctgtacctgc
     4981 agtcaagaca cagttaatgc atactgtcta tggtggtttg catatgccct gccccaggga
     5041 atggcactgt taggaggtgt ggccttgttg cagtgggtgt gtcactgtgg tcgtgggctt
     5101 aagaccctca tcctaactgc ctgggagcca gccttcttct agcagccttc agatgaagat
     5161 gtagaactct cagctcctcc tgcaccatgc ctgcctggat gctgctgtgt tcccaccttg
     5221 atgataatgg actgactttc tgaacctgaa agccagcccc aattcaatgc tgtcctaata
     5281 agagttgcct tggtcgtggc gtctgttcac agcagtaaaa ccctaactga gacaccgact
     5341 ccactcagct gtctccacgc atacattccc aggacccggt tagaaaatgc tgccacccat
     5401 aggaagaagc tcttttcatt ccaattaatg taatcaagtt aactccccac agacgtgctt
     5461 agcagcccaa ctcccaggtg actctagatt ctgttcacag caacctgcac gcccacagca
     5521 agtgttggta ttggtttggt agtgagggta gcggggtttg agaaggatgt gtctccagtg
     5581 tgtgaaccag gtaggtgctt tctccatgct ggtctcattc cgcctccaac tccacctggg
     5641 agtttggtcg gtgtcagcac agatctgact atcagctaag agtcaaataa ggctacgatg
     5701 cctggaacac ccagcctcag ctcttaggac attaaccctt gtacacagac accctgagtg
     5761 tttgaaggga cagcactctt aaggagtaaa tgattgatac actaagattg accttctgtt
     5821 tggttgatgg gtaactgcat ttatatctcc aaggtttgtt tggaatctta gcaacgagct
     5881 gatgtttctg gatttttctt ttctttctgt tttgtacttt ggcatggggc gagccccacc
     5941 tctagggcag acacttggca tctcggcaga cttggaatgt ggtgattctg cttctgagga
     6001 aatgacggca ggagtttctt ttactctaag gaaaatgaac gttgtggaaa tcttgttggc
     6061 tgcttagtgt cttacgtgtt ttctgttttt gctgcacaag caaagaaagg aaaaagaaca
     6121 gggtccctct agccctggtg ggtgaccgtg tgactgcact ttgtccagtg ttggaactga
     6181 gggcctctga gggtgtgctg ctctctgctg aagtcaagat agagtcagga catgatggtt
     6241 tggaacgttt cagtggcaga tgtgagccca atagctcttt ggtgtagtgt ttcactttag
     6301 gggccctccc tagcttgcag aaagtcttca ttttgatact tggttttgtt ttgttttatg
     6361 tccccatttt ttctgtaata ttattcacaa gaaggtaatg actccagctg aaagtggaac
     6421 tctgccagca ctctctgcct ctgtgtttat ccaagcagac atgtcaggga tgctctgccc
     6481 acatccatga agagggcagc accgtgagat gctgagggat ctggcaggaa gtgggtcctg
     6541 gcagcagctt cacctggctt tgtggccagg tttgggtgtc tgcgtattcc aatgtgaggt
     6601 tgctctcccc cgccccgtca tgcttcgtag agctttgact agtacctact actaactagt
     6661 atgtacccgt ggccatttac taaagatccc tacctgtctg aggcaaagtc gggccagctg
     6721 tctgtcactg tgctccacac ttgagttttt accctaggca taaatgctct aaaaccttgt
     6781 atgtttgtca cctgtgccaa gacgaaataa actatgtgga aactccca
//
LOCUS       NM_001106078            1302 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase 6 (Tssk6), mRNA.
ACCESSION   NM_001106078 XM_001071471 XM_224740
VERSION     NM_001106078.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Jha,K.N., Coleman,A.R., Wong,L., Salicioni,A.M., Howcroft,E. and
            Johnson,G.R.
  TITLE     Heat shock protein 90 functions to stabilize and activate the
            testis-specific serine/threonine kinases, a family of kinases
            essential for male fertility
  JOURNAL   J Biol Chem 288 (23), 16308-16320 (2013)
   PUBMED   23599433
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Spiridonov,N.A., Wong,L., Zerfas,P.M., Starost,M.F., Pack,S.D.,
            Paweletz,C.P. and Johnson,G.R.
  TITLE     Identification and characterization of SSTK, a serine/threonine
            protein kinase essential for male fertility
  JOURNAL   Mol Cell Biol 25 (10), 4250-4261 (2005)
   PUBMED   15870294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474031.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071471.1, XM_224740.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1302
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="testis-specific serine kinase 6"
                     /db_xref="GeneID:290670"
                     /db_xref="RGD:1559764"
     exon            1..1302
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..915
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     6"
                     /protein_id="NP_001099548.1"
                     /db_xref="GeneID:290670"
                     /db_xref="RGD:1559764"
                     /translation="MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVD
                     RRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQ
                     RNGRIPGSQARELFSQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQ
                     AHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIA
                     GLPRRQKRGVLYPDGLELSERCKSLIAELLQFSPSARPSAGQVARNGWLRAGDSG"
     misc_feature    124..894
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="Catalytic domain of testis-specific
                     serine/threonine kinase 6 and similar proteins; Region:
                     STKc_TSSK6-like; cd14164"
                     /db_xref="CDD:271066"
     misc_feature    124..894
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="Catalytic domain of testis-specific
                     serine/threonine kinase 6 and similar proteins; Region:
                     STKc_TSSK6-like; cd14164"
                     /db_xref="CDD:271066"
     misc_feature    order(145..159,169..171,208..210,214..216,310..312,
                     361..372,379..381,385..390,394..396,493..498,502..504,
                     508..513,517..519,550..555,562..564,607..621,625..627,
                     715..726)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="active site"
                     /db_xref="CDD:271066"
     misc_feature    order(145..159,169..171,208..210,214..216,310..312,
                     361..372,379..381,385..390,394..396,493..498,502..504,
                     508..513,517..519,550..555,562..564,607..621,625..627,
                     715..726)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="active site"
                     /db_xref="CDD:271066"
     misc_feature    order(145..156,169..171,208..210,214..216,310..312,
                     361..372,379..381,508..513,517..519,550..555)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271066"
     misc_feature    order(145..156,169..171,208..210,214..216,310..312,
                     361..372,379..381,508..513,517..519,550..555)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271066"
     misc_feature    order(379..381,385..390,394..396,496..498,502..504,
                     508..510,562..564,607..621,625..627,715..726)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271066"
     misc_feature    order(379..381,385..390,394..396,496..498,502..504,
                     508..510,562..564,607..621,625..627,715..726)
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271066"
     misc_feature    550..621
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271066"
     misc_feature    550..621
                     /gene="Tssk6"
                     /gene_synonym="RGD1559764"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271066"
ORIGIN      
        1 ggtgccaagc accatgggtt aggcccgaga ttggagtccg gccgcccccc gacagcagcc
       61 gcctcctgct ccccgcgcgc cccgggcgcc accatgtcgg gcgacaaact cctgagcgaa
      121 cttggctata agctgggccg cacgataggt gagggcagct actccaaggt gaaggtggcc
      181 acctccaaga agtataaagg gacggtggcc atcaaagtgg tggaccgccg gcgagcgcct
      241 ccggacttcg tcaacaagtt cctgcctcga gagctgtcca tcctgcgggg agtacggcac
      301 ccgcacatcg tacacgtctt cgaattcatc gaagtgtgca acgggaagct gtacatcgtg
      361 atggaggcag cagccaccga cctgttgcag gcagtgcagc gtaacgggcg catcccgggg
      421 tcgcaagcgc gcgaactctt ctcgcagatc gcaggcgctg tgcgctacct gcacgaccac
      481 cacctagtgc accgcgacct caagtgcgaa aacgtgctgc taagtcctga cgagcgccgc
      541 gtcaagctca cggatttcgg tttcggccgt caggcgcacg gctacccaga cctgagcact
      601 acctactgcg gctcggccgc gtatgcgtca cctgaggtgc tcctgggcat cccctacgac
      661 cccaagaaat acgacgtgtg gagcctgggc gttgtgctct acgtcatggt caccgggtgt
      721 atgcccttcg acgactcgga cattgctggt ctaccccggc gccagaagcg cggcgtgctc
      781 taccctgacg gcctcgaact gtcggaacga tgcaagtctt tgatcgccga gctgctacag
      841 ttcagcccgt ccgcccggcc ctcagcgggc caggtggcgc gcaatggctg gctgcgggcc
      901 ggggactccg gctaggagcc ggggttctcg ctgttcccgc cgcaccaggc acagagccag
      961 ggcggcgcac gcgcgaaggg cgagcttcgg gaaacccgcg aaatcgccgc gcgccactgc
     1021 gcacgcgccc tgtcccttcc ccttccccca cggcggcggc ccgctgaggc cggctgttgg
     1081 gttctgattc ctcctacaca acccgattgc tggagagcgc atgcgcatcc tcgatttctg
     1141 gtgagaaggc cccgggaggg gcgcaaagag aagagagaga agcattgcgc ctgcgcggaa
     1201 tgagctgttg cgcggtgggt taccgcggtg cagagaaact gcggatcagc cgtgcacgcc
     1261 aagttccagg ttggaacctg caataaattc gctcttcctc gc
//
LOCUS       NM_001107972           11654 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus HIVEP zinc finger 3 (Hivep3), mRNA.
ACCESSION   NM_001107972 XM_001053243 XM_017593396 XM_233464
VERSION     NM_001107972.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11654)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   2  (bases 1 to 11654)
  AUTHORS   Wu,L.C., Goettl,V.M., Madiai,F., Hackshaw,K.V. and Hussain,S.R.
  TITLE     Reciprocal regulation of nuclear factor kappa B and its inhibitor
            ZAS3 after peripheral nerve injury
  JOURNAL   BMC Neurosci 7, 4 (2006)
   PUBMED   16409637
  REMARK    GeneRIF: ZAS3 is expressed in nervous tissues involved in cognitive
            function and pain modulation; reciprocal changes in the expression
            of ZAS3 and NF-kappaB might generate neuropathic pain after
            peripheral nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11654)
  AUTHORS   Bettelli,E., Dastrange,M. and Oukka,M.
  TITLE     Foxp3 interacts with nuclear factor of activated T cells and
            NF-kappa B to repress cytokine gene expression and effector
            functions of T helper cells
  JOURNAL   Proc Natl Acad Sci U S A 102 (14), 5138-5143 (2005)
   PUBMED   15790681
REFERENCE   4  (bases 1 to 11654)
  AUTHORS   Hicar,M.D., Robinson,M.L. and Wu,L.C.
  TITLE     Embryonic expression and regulation of the large zinc finger
            protein KRC
  JOURNAL   Genesis 33 (1), 8-20 (2002)
   PUBMED   12001065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 21, 2025 this sequence version replaced
            XM_017593396.3, NM_001107972.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360194.96769.1, SRR21887620.956298.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000005.1  138610650-138610716
            68-180              JAXUCZ010000005.1  138697887-138697999
            181-258             JAXUCZ010000005.1  138876429-138876506
            259-455             JAXUCZ010000005.1  138943244-138943440
            456-5949            JAXUCZ010000005.1  138973490-138978983
            5950-6083           JAXUCZ010000005.1  138983024-138983157
            6084-6259           JAXUCZ010000005.1  138998131-138998306
            6260-6346           JAXUCZ010000005.1  139003411-139003497
            6347-7257           JAXUCZ010000005.1  139006762-139007672
            7258-11654          JAXUCZ010000005.1  139008662-139013058
FEATURES             Location/Qualifiers
     source          1..11654
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..11654
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="HIVEP zinc finger 3"
                     /db_xref="GeneID:313557"
                     /db_xref="RGD:1311252"
     exon            1..67
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            68..180
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            181..258
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..455
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..5949
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    955..957
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="upstream in-frame stop codon"
     CDS             973..8025
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="human immunodeficiency virus type I enhancer
                     binding protein 3"
                     /codon_start=1
                     /product="transcription factor HIVEP3"
                     /protein_id="NP_001101442.1"
                     /db_xref="GeneID:313557"
                     /db_xref="RGD:1311252"
                     /translation="MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSTPYPGSSTTA
                     SSEGASQELLAPQPFSGPSVALREGAQEKTGQQQKPPRRPSIEASAHIPKLPQHPLTP
                     AFMSPSKPEHLLEGSTWQLVDPTRPGPSGSFVAPGLHPQSQLLPSHASILPPEDLPGI
                     PKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGER
                     PYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEP
                     TEGESTDSEEETGATSGPSTDVLPKSKHPLLSSSLYSSGSHGSSQERCSQSSTAPSLE
                     DPTPFAEASSEHPLSHKLEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYF
                     SRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLV
                     PLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLS
                     SHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHIA
                     DPEVPSRSTPVFTSHPRMLKRQPAIELPLGAEYSSEEPGPSSKDPITKPSDEPEPKES
                     DLTKKTKKGLKTKGVNYECTICGARYKKRDNYEAHKKYYCSELQITKAHPAGAHEVEK
                     TQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPGFSSPGPSDAAHNLPLE
                     STKSPAEASKSVPTLEGPTSFQPRTPKPGSGSEPGKERRTMSKEISVIQHTSSFEKSD
                     PPEQPGSLEEDKPLAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDT
                     EPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVP
                     LSRSPSQESSISLSGSSRSASFDREDHGKAETPGPLSDTRSKTLGTHMLTVPSHHPHA
                     REMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPAAPPPPAAPPERRKC
                     FLVRQASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKS
                     QMQDRPPLGSSPPYTEALQVFQPLGTQLPPPVSLFSLQQLLPQEQEQSSEFFPTQAMA
                     GLLSSPYSVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMP
                     CPAPSTLSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQ
                     LPPVTPQATSPAPTSASPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVT
                     QSPGSSTSMALTKYEEPSSKSMTVCGADVYEAEPGPSSISKEQSRGFQTPYLRVPERK
                     GTALSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLEL
                     VSTCNVVLTSTEDRKKTEKPHVGSQGRSRRETETLSCLSSDVSDPKELSPLSQSTLSH
                     GTAPGSEALKEYAQPSSKAHRRCLPPLSVKKEDPKEQTDLPPLAPPSSLPLSDTSPRP
                     AKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPN
                     LPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSMVSL
                     ESQKDPARVEKEEKAEEGTPTSKRGEPTRVKIFEGGYKSNEEYIYVRGRGRGKYVCEE
                     CGIRCKKPSMLKKHIRTHTDVRPYVCRHCHFAFKTKGNLTKHMKSKAHSKKCQETGVL
                     EELEAEEGTSDDLLQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEEESQ
                     DELSRPSSEAAPLCLPATLQEDSSLIRGPQPPDATSDAAPRGSSISEATRLTASSCST
                     PSQGTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKTDS
                     SPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPELSCLTPYPIGREVPAGLES
                     ATVTGTPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALL
                     QPVPLPHTLLSRSPETCASAWKTESRSPSAGPAPLSSRPSSAPHDFHGHLPSRSEENL
                     FSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTG
                     AREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAP
                     AETMGTHSPCPPQLPQGHPLAPSWRGLLESPHALANLKASSFPPLDRSSSMDCLAETS
                     TCFPPRSRNLSGEPRTRPDSPELLGSGELRTPLFLSKDSGPPSI"
     misc_feature    1552..1614
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1552..1614
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1591..1665
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1591..1665
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1636..1698
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1636..1698
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    <4075..4794
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <4075..4794
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    6136..6204
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    6136..6204
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    6142..6204
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    6142..6204
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    6178..6255
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    6178..6255
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    6226..6294
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    6226..6294
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    6799..>7932
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    6799..>7932
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     exon            5950..6083
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            6084..6259
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6346
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            6347..7257
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
     exon            7258..11654
                     /gene="Hivep3"
                     /gene_synonym="Zas3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggcgcc cgccgccgcc gctgctcgca cgccgggcct cggaagccac ctcagccgag
       61 cgcgcaggtg tttatgaaaa aaaatgcact atatcccgac tgaccggaat aattgaagaa
      121 gggtgctgga tccgtgggtc agagaacaca caggaccagc ttgctacccc aaggctgaag
      181 gtctccctct gacagccttg acgctcttga gaatctctgg cctgccttga ccatgacatc
      241 ccagcaagct cctgatagga gcagaggcac aaaccaagct gccttgaagt agctcatggg
      301 agactctcga gagccactga ccaggcacac tgtccctccc tcaggaagga gcagtgcgta
      361 agcagaggca tcgcagcagg agtggacatg aacgctggct tccagagaga gcagcggttc
      421 agttttggtc accggaagtg gtgcctgcag cgcagaagac cgtgatttct cctccgaggt
      481 gttaatctcc agtgcagaat tcaaagcaga agagggccac tccagcatcc atcgtggcat
      541 ctctccagcc cggactaggc atgacagacc catggaaaca ggtgtctctg ccctccagct
      601 gttcatatag cacacagggg actcgtgggg gccactcgtc actcaaatcc actcaatggc
      661 aatactgaca tcttccatgc tgttttcaag acagacgttc aggcagaaaa atgccagtgt
      721 gctttctgtc tgcagagtag agggctatgc cacaccaaaa tgaacagtgt gggccccggg
      781 acctgctctg agtccacttg cagccactga cacttgaggg gataaaaagc ccagccccaa
      841 agccaccgtg gggttggctt ccacagctct tgaccaatgt ggccaaagct agacacttca
      901 ggacacttgg attattcata aatgcgacct accccaaact ccctgagtag catctgaagt
      961 cttgtaaagg tcatggatcc tgaccaaagc atcaagggca ccaagaaggc tgatggaagt
     1021 ccccggaagc ggctgaccaa aggagaggcc attcagacta gtgtttcttc cagcactcca
     1081 tacccaggca gcagcactac tgcttcctca gagggtgcca gccaggagct cctagccccg
     1141 cagcctttct caggcccctc agtggctctt agggaaggcg ctcaggagaa aacgggtcag
     1201 cagcagaagc ctccccggag gccatccatc gaggcctcag cccacatccc gaagcttccg
     1261 cagcaccctc tgacaccagc attcatgtcc cctagcaaac cagagcatct cctcgagggg
     1321 tccacgtggc agctggtcga ccccacaaga cctggaccct caggctcctt tgtggccccg
     1381 gggctgcatc cacagagcca gctcctccca tcccatgctt ctatccttcc tcctgaggac
     1441 ctgcctggca tccctaaggt ctttgtgcct cgtccctcac aggtctccct gaagcccaca
     1501 gaagaggcac acaaaaaaga gaggaaaccg cagaagccgg gcaagtatat atgtcagtac
     1561 tgcagccggc cctgcgccaa gcccagtgtg ctccagaaac acattcgctc acacacaggt
     1621 gagaggccct acccctgtgg cccctgtggc ttctccttca agaccaaaag taacctctac
     1681 aagcacagga agtcccatgc ccaccgaatc aaagctggcc tggcctctgg ctccagcagt
     1741 gagatgtacc cccctgggct ggagatggag aggatccctg gggaagagtt tgaggaaccc
     1801 actgagggag aaagcacgga ctctgaggag gaaactggtg ccacgtcagg tccctccaca
     1861 gatgttctcc ccaaatctaa gcaccccctg ctctcaagta gtttgtacag ctctgggagc
     1921 catggttcca gccaggaacg ctgctcccag tcaagcactg caccatcgct ggaagacccc
     1981 accccatttg cagaagcctc atcggaacat cccctgagcc ataaactgga agacacacac
     2041 accatcaagc agaagctggc cctccgcctg agtgagagga agaagctgat cgaggagcag
     2101 acatttctga gcccagggag caaaggcagc acggagtctg gttatttctc acgctctgag
     2161 agcgctgaac agcaggtcag cccccccaac accaatgcca agtcctacgc agagatcatc
     2221 ttcggcaagt gtggacggat tgggcagcgg acctccatgc tggcatccac ctccacccag
     2281 cccctactgc ctctgtctgc tgaagacaag cccagcctgg tgcctttgtc tgtgcccagg
     2341 acacaggtga ttgaacacat caccaagctc atcaccatca atgaggctgt ggtggatacc
     2401 agtgagatcg acagcgtgaa gcccaggagg agttccctaa ccaggcgcag cagcgtggag
     2461 tccccaaaat ccagcctgta ccgggagtca ctatcgtccc acggggagaa gacaaaacag
     2521 gaacagtcac tgctgagcct ccagcaccca cccagctcca cgcaccccgt gcctctgctg
     2581 agaagccact caatgccttc tgctgcctgc accatcagca cccaccacca caccttccgc
     2641 ggtagctact cctttgatga ccacattgct gaccccgagg tccccagccg cagcactccc
     2701 gtgtttacct cccacccacg gatgctaaag cgccagccag ccattgaatt acctttggga
     2761 gctgagtaca gttccgagga acctggacca agcagcaaag accccatcac caagccgtcc
     2821 gatgaaccag aacccaagga aagcgacctt accaaaaaga ccaagaaggg gttgaaaacg
     2881 aaaggcgtga actatgaatg taccatctgc ggtgctcggt acaaaaagag agataattat
     2941 gaagctcata agaagtacta ctgctctgag ctccagatca ctaaagccca ccctgcaggt
     3001 gctcatgaag tggaaaagac tcaggctgag cctgagcctt ggtcccagat gatgcattat
     3061 aaactggggg ccacattgga actcacccca ctgagaaaaa gacgaaagga aaagagcctt
     3121 ggggatgagg aagagccgcc tggcttcagc agccctggcc catcagacgc agcccataac
     3181 cttcccctgg agtctaccaa gtcaccagca gaagcaagca aatcagtacc cactttagag
     3241 ggacccacga gcttccagcc caggactccc aagccaggat ctgggtcaga accagggaag
     3301 gagaggagaa cgatgtccaa agaaatttcc gtcatccagc acaccagctc ctttgagaag
     3361 tctgacccac cagagcagcc aggcagcctg gaagaagaca agcccctggc cccgttctca
     3421 tccccgccac ctgccccgca cggacgctcc gctcactctc tgcagccgag gctggtccgc
     3481 cagcccaaca ttcaggttcc agagatcctt gtgaccgaag aaccagacag gcccgacaca
     3541 gagcctgagc cacccccaaa ggagcctgag aagacagaag agttccagtg gccccagcgc
     3601 agccagacac tggcacagct cccagcagag aagctgccac ccaagaaaaa gagactacgc
     3661 ctggctgaga tggcgcagtc ctcaggggag tccagctttg agtcctccgt gcctctgtct
     3721 cgaagcccaa gccaggagag cagcatttct ctaagtggct ccagccgctc agcttcattt
     3781 gacagggaag accatggaaa agctgagacc cccggacccc tatcagacac acgctccaaa
     3841 accttgggca cccacatgct gactgtcccc agccaccacc cacatgcccg agagatgaga
     3901 aggtcagcct cagagcagag ccccaatgtg ccccattcct cacacatgac tgagacccga
     3961 agcaaatcct ttgactacgg cagcttgtcc ccaacaggac catctgtagc agtgcctgca
     4021 gctcctccac ccccagccgc cccaccagaa agaagaaaat gctttctggt aagacaggcc
     4081 tccctgagca gacctccaga agcagagctg gaagccaccc ccaaaggaaa acaagagagc
     4141 agtgaggaac cctcagccag caagccttcc acaaaaagtt ccatggccca gatctctgtg
     4201 gccactatac aaggtgggct ctcgggaagc aagagccaga tgcaggacag acctccactg
     4261 gggtccagcc caccctacac agaagctctg caggtgttcc aacctcttgg cacccaactg
     4321 ccccctccag tctccctctt ctccttgcaa cagctcttgc cccaggagca agaacagtcc
     4381 tctgagttct tccccacgca ggcaatggct ggcctcctct cctccccata ttctgtgccc
     4441 ccactcccac cttcattgtt ccaagcccca ccacttcctc tacagcctac tgtgctacac
     4501 cccagccagc tccatctccc ccagctcttg ccccatgctg cagatatccc cttccaacag
     4561 cccccttcct ttctccccat gccatgccct gccccctcaa ccctctctgg atattttctc
     4621 cctctgcaat cccagtttgc actgcaactc cctggtgaaa tagaaagcca cttgccctca
     4681 atcaaaacca gcctgccccc tctggcaaca ggacctcctg gcccctccag tagcacagaa
     4741 tatagtagtg acatccaact gccgcctgtg actccccaag ccacctcccc agctcctaca
     4801 tcagcctcac cactggccct gcctgcctgt ccagatgcta tggtgtcact ggttgttcct
     4861 gtccgcatcc aaacccacat gccatcctat gggagtgcca tgtataccac tttgtctcag
     4921 atcttggtca cacagtctcc aggtagctca acaagcatgg ctcttaccaa gtatgaggaa
     4981 ccctcctcca aaagcatgac tgtttgtggg gctgatgtat atgaggctga gcctgggcca
     5041 tctagcataa gcaaagaaca aagcagaggt tttcagacac catatctgag agtacctgaa
     5101 aggaaaggca ctgcactgtc ttctgagggc atcctcagcc tggaggggtg ctcatccaca
     5161 gccagtggaa gcaagcgtgt cctttcccca gctggcagtc ttgaacttac catggaaacc
     5221 cagcagcaaa aacgggtaaa ggaagaggaa gcttccaagg cagatgaaaa actggagctt
     5281 gtgagtacct gtaatgttgt gctaaccagt acagaggaca ggaagaagac agagaaaccc
     5341 catgtgggaa gccaaggccg aagcaggagg gagacagaaa cactgtcctg cttgtcttca
     5401 gatgtatctg acccaaaaga actttctccc ctctctcagt ccacattgtc ccatgggaca
     5461 gccccaggct cagaagcttt gaaagaatat gcccaaccat ctagcaaagc tcaccgaaga
     5521 tgtctgcctc cactgagtgt aaagaaagaa gatccaaagg aacagactga cctccctccc
     5581 ctagcacctc ctagttctct gcctctgtca gatacttccc ctagaccagc caaattgcaa
     5641 gaaggtacag actcaaagaa ggtactgcag ttccccagcc tccacacgac cactaatgtc
     5701 agttggtgct atttaaacta cattaagcca aatcacatcc agcatgcaga taggaggtcc
     5761 tctgtttacg ctggttggtg cataagtttg tacaacccca accttccagg ggtttccact
     5821 aaagctgctt tgtccctcct gagatctaag cagaaggtga gcaaagagac atataccatg
     5881 gccacagctc cacatcctga ggcaggaagg ctggttccat ccaactcccg aaagccccgc
     5941 atgacagagg tgcacctccc gtcgatggtt tccctggaga gccagaaaga cccagctaga
     6001 gtggagaagg aagaaaaggc agaggaaggt actccaactt ccaagagagg cgagccgacg
     6061 agggtcaaga tcttcgaagg agggtacaaa tcaaacgagg agtatatata tgtgcgaggc
     6121 cgcggccgag ggaagtatgt ctgtgaggag tgtggaattc gctgcaagaa acccagcatg
     6181 ctgaagaaac acatccgcac ccacactgac gtccgaccct atgtgtgcag gcactgtcac
     6241 tttgctttta aaaccaaagg gaatctgact aagcacatga agtcgaaagc ccacagcaaa
     6301 aagtgccaag agacgggggt gctggaggag ctggaagccg aagaaggaac cagtgacgac
     6361 ctactccagg actcagaggg gcgagagggc tccgaagctg tggaggagca ccagttttca
     6421 gacctggagg actctgactc agactcagac ctggatgaag atgaagagga ggaggaggag
     6481 gaggaagagg agagccagga tgagctgtcc aggccatcct cagaggcagc tccactctgc
     6541 ctgccagcca cactacagga ggactcctcc ctgattcggg gccctcagcc tccagatgcc
     6601 acttcagacg cggccccacg aggcagctcc atctcagaag ccacgcgtct gacagccagc
     6661 agctgttcca cacccagcca gggtacccaa ggccttcctc ggctgggact ggccccactg
     6721 gagaaaggca cgagctcagc cctgagtccc aaggccacat cccctaggag gccgtggtcc
     6781 ccaagcaaag aagcaggcag ccgcccctca ctcactcgca aacattcact caccaaaacc
     6841 gactcatctc cccagcgatg ttcaccggcc cgagctcagg cctcagtcgc gagcacacct
     6901 ggtccccaga cgggcccagg aagggaccta agtcctcacc tttgtgggtc tccgagacca
     6961 gagttgtcct gtctgactcc ctaccccata ggaagagagg tgcccgctgg acttgagagt
     7021 gccacagtca caggcacccc cagatgttca cccaccagga gacggtccct gggtcgggcc
     7081 gagtcatcgc cgccgcacac agtgctgccg gggacgtggg ccctaggtgg gccctgcagc
     7141 ccctcagtgg acaagtatgg cctgggcttg gggccggttc cacgggctct cctccagccc
     7201 gtgcctctac ctcacacact tctcagcaga agcccggaaa cgtgcgcctc tgcatggaag
     7261 actgaatccc gaagtccatc agctggtcct gctcctctct cttcccgacc atcctctgcc
     7321 cctcatgact tccacggcca cctccctagc cgaagtgagg agaacctctt cagccacctg
     7381 cctctgcatt cccagcacct gaatcgcacc ccctgccccc tcattcccat cggtgggatc
     7441 caaatggtac aggcccgacc aggagcccac cccaccctgc tgtcaggacc ctgtgcagcc
     7501 tgggtcagtg gcttctcagg gggtggcagt gacctaactg gggcccgaga ggcccaggag
     7561 cgcagccgct ggagtcccac ggagagccct tcagcatcag tgtcccctgt ggccaaggtc
     7621 tccaagttta cactctcttc agagctggag gaggaaagga ccagccgagg cccaggaaga
     7681 cctcctgcct gggaacctca cagggctgaa gcccctgcag aaaccatggg cacacacagc
     7741 ccctgccccc cacagctgcc ccaagggcac ccgctggcac catcctggag gggcctcctg
     7801 gaatcaccac acgcactggc caacctaaag gcctcaagct tcccgccact ggaccgcagc
     7861 agctccatgg actgcctggc agagacctcc acttgctttc caccccggag caggaacctc
     7921 tctggagaac ccaggacccg cccagactcc cctgagctct taggtagtgg ggagctcagg
     7981 acacctctat tcctgtccaa ggatagcggc cccccaagca tctaagcctc tgcagtactt
     8041 cagcactggc ctcagtgttc ggcagcagac acttcctgcc aaccgcctgg agtcatactg
     8101 ctcccgcggg catcctctcc catctgtcca tctgtccatc tgtccatgca gcttctgctc
     8161 agccccgtct gttctatttt tccacatatg cagttacctg tgcctttttc tagacctttt
     8221 gttgcttgaa aaaaaaatca cacacatcca taaacgaaac gaaacaaaca catccacgag
     8281 gagctctagg ctgtgagtag tttgtgctct ggggacaagg ctggaggagg gactctccac
     8341 ctccaccacc acatgccgta ctggcagccg tccccacctc aaggtccctg agagagaggg
     8401 tctattgcac tgagagagaa gaaaggggga gaaaaatata attaaattca aaggcaagca
     8461 ctcctacaga cagattccca agatccccac tcataacaca tacggttcat agccaccccg
     8521 ctctgccatc agaggaacca gaaccccaaa gcaggacaca aatacaggca ggaaccaacc
     8581 cgctactccc caccctacct agctaagaac attatctttt atcctatgta gtgtgaacca
     8641 agctctcacc ttctcccttc cttactccac ctccgcccag ggcttgccca tctgtctcct
     8701 ttctcctaca cactgtaggt ctctgcctcc tgggcctggc cacacgctgg ctcctttatg
     8761 ttcagaaata cccacaggat ggaggggcca aggcaggact agggatggtc ctagtctgga
     8821 cctgttctga gcctggagtt tggattctgt ttcacctgtg gccctgagac agcacatcac
     8881 acttccttcc tggcaggatt gacgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     8941 tgtgtgtgtg tgtgtataca cacagagaga aaccaaagat ggtgcttggt actttctctg
     9001 gcctcctcag atcctctgct cttaacttag aggattggta aattgtccca aaccctttaa
     9061 atttttctcc agttcccaag gaaaaaaaaa acacaacaaa acaaacaaaa aaacaaacaa
     9121 acaaaaaaat ccctgcttaa aaaaaatgaa atataaccaa aaatttaaat cccaagttga
     9181 aatttggaac ttgacctgtt gcatgcttaa aaaaaaaaaa gcaagccctc tgaggcacag
     9241 gctctatggc taccatttct aagaccttcc ggaaatgttt ctttaccttc tccaaggaag
     9301 aaagagaggg gaaaggacca ttgtgaggag gcccctccta tagccttgtt cccaaatcac
     9361 aaagcctgtt ctggccatgc tggatactgt tgtcacgctg tacaaagcag ggcctgtccc
     9421 tgggcatcag gctgggtgtg tggctgaagg ctcatgggga gctgagctgc agggctatgg
     9481 actccctgta ctaggccacc cctagttcct gtcatgcctg gtccttgctg gatgggcaaa
     9541 tcagccacag gcccagtgcc cagcgcagtc tcctggtttc ttctttgtct gactcaacgc
     9601 ttaagacata agcattagga ggactggggc cttccctgct gtatgctcag ctgcacggtg
     9661 gcatgggtag cagactgggg gcctccagat acctgccttg ctgcaagtct cctgcccacc
     9721 tgggagaagc tgtcaggaac agggctgggg cactggaagg aagagggtag aagcccaacc
     9781 tagaggccac agcttctctc ccttctgcct ctcagcccta ccccaccggc cccactgatg
     9841 ctaaaggctg agttggacaa aaaaaaaaaa aaaaaacatc gtctcaaact gaactttatg
     9901 gctttccagg caagagcttc tggccataga tggaaggcta aatcctgacc ttgggatacc
     9961 tctccactct actcccaaat ctctctgtgt ctctctgtct ctgtttctct ctctctctct
    10021 ctctctctct ctctctctct ctctctctct ctctctgttc ccttcctcca ttcccctgct
    10081 catgtcccct tcagcagcct agtgacagac aaatgtgacg acagaataac ccccacagtt
    10141 actgggcacc cttgactcag ggaaacggga tgtaacaaag ggtaggaatt ggagacttgc
    10201 ctttaggtga cagggataga atacacagag tctagctagg gttggtacca cacacatgtc
    10261 cagagaattg gcagtggatg tcactaccag gcacagctct taaactccta agctctctcc
    10321 cacccccacc ccaagcacag gaccccagcc tgcaaacacc ttctctacct agagaaactc
    10381 tcactccagg agtgtgcttg gggctcctca cccacaacca gccacttctg actttgcagt
    10441 ctgcctgtga cactactgtt gatgacagtc tagttcagac atttatgtgg ggtctgctga
    10501 cacacaccag aataagatgg cctcgctaca gactgtcttt gctcctcctt acctctacca
    10561 gttggggagg tctagtcaaa tcagtcctct gagggtggta gttcccagcc actcatccct
    10621 gaggcctgag ccctagttgg ccctccctgg gtaacctcac atcattgtgt gtactaaacc
    10681 ccttccacac caagggcagg cccgcttttc ccactcccat catagctgat actctggtcc
    10741 cagccaccaa gaccttccag ggcttctgac aggggtagct acctattttt ccagacacaa
    10801 agtctctgcc tgcctcagca gggaaacctc ttaagagaaa tgactcccca ttccctctgg
    10861 gtgttgccca cccccacctg gcccaggaag agggaatatg tctgagctga agtctcctcc
    10921 tagtccttgc tccagctgag tcctccaggt aaagtcctgg gagacaggtc ctctctgcag
    10981 tgtcttctga gaaagttccc agagtcagtg ccaccaaatt tgtttctgtg ttgtggttcc
    11041 tgtctgcttg gcatttgaaa accgcttggg ctctacggat cactttactg aatgtggtga
    11101 tcaagaagaa agggaaccct gcaggcaaat gtaagatact tacactctgt aagataaatt
    11161 tctgcctccg tgtttttggg tttttttttc tttgaaaagt tgtacgtgtt ctgtacgtga
    11221 aatcgtctgt agagagtttc cacgttctta aatggcaata cattccaaac ctcgtactgt
    11281 agataatgta cagcatccgc actggaaagg ggtagttttg cctgtggttt tatttaaact
    11341 ccagtttcta cacttgtatc ttgcagttgt cggtatggta ttcatcagtg caaaagaaaa
    11401 acaaaaaaac aaaaaaaact taaacaaaaa aaaatctaca caggtctaaa gcacagagtc
    11461 tgttatacaa aaggaaagaa tcgctcagta ttggtgtgtg tgacccttgt tgtaaatccc
    11521 atctgtactg tgaatgagac gtttttacaa gtatgacaat tacctttatt acagcttggg
    11581 ctgagtgttc agcctgaaga tattttttaa aaaaaaaata gcacgttgga ataaatttga
    11641 aaattcccaa caga
//
LOCUS       NM_001436564            6376 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus multifunctional ROCO family signaling regulator 1
            (Mfhas1), transcript variant 1, mRNA.
ACCESSION   NM_001436564 XM_006253224
VERSION     NM_001436564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6376)
  AUTHORS   Wang,H.H., Sun,P.F., Chen,W.K., Zhong,J., Shi,Q.Q., Weng,M.L.,
            Ma,D. and Miao,C.H.
  TITLE     High Glucose Stimulates Expression of MFHAS1 to Mitigate
            Inflammation via Akt/HO-1 Pathway in Human Umbilical Vein
            Endothelial Cells
  JOURNAL   Inflammation 41 (2), 400-408 (2018)
   PUBMED   29168081
REFERENCE   2  (bases 1 to 6376)
  AUTHORS   Shi,Q., Xiong,B., Zhong,J., Wang,H., Ma,D. and Miao,C.
  TITLE     MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C
            subunit cytoplasm translocation and inhibition of c-Jun
            dephosphorylation at Thr239
  JOURNAL   Mol Immunol 88, 79-88 (2017)
   PUBMED   28609714
REFERENCE   3  (bases 1 to 6376)
  AUTHORS   Zhong,J., Wang,H., Chen,W., Sun,Z., Chen,J., Xu,Y., Weng,M.,
            Shi,Q., Ma,D. and Miao,C.
  TITLE     Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1
            macrophage polarization by activating JNK and p38 pathways
  JOURNAL   Cell Death Dis 8 (5), e2763 (2017)
   PUBMED   28471450
  REMARK    Erratum:[Cell Death Dis. 2018 Jul 16;9(8):782. doi:
            10.1038/s41419-018-0828-y. PMID: 30013073]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6376)
  AUTHORS   Zhong,J., Shi,Q.Q., Zhu,M.M., Shen,J., Wang,H.H., Ma,D. and
            Miao,C.H.
  TITLE     MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB
            Signaling Pathway Following Negative Regulation
  JOURNAL   PLoS One 10 (11), e0143662 (2015)
   PUBMED   26599367
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6376)
  AUTHORS   Dihanich,S., Civiero,L., Manzoni,C., Mamais,A., Bandopadhyay,R.,
            Greggio,E. and Lewis,P.A.
  TITLE     GTP binding controls complex formation by the human ROCO protein
            MASL1
  JOURNAL   FEBS J 281 (1), 261-274 (2014)
   PUBMED   24286120
REFERENCE   6  (bases 1 to 6376)
  AUTHORS   Kumkhaek,C., Aerbajinai,W., Liu,W., Zhu,J., Uchida,N.,
            Kurlander,R., Hsieh,M.M., Tisdale,J.F. and Rodgers,G.P.
  TITLE     MASL1 induces erythroid differentiation in human
            erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK
            pathway
  JOURNAL   Blood 121 (16), 3216-3227 (2013)
   PUBMED   23327923
REFERENCE   7  (bases 1 to 6376)
  AUTHORS   Ng,A.C., Eisenberg,J.M., Heath,R.J., Huett,A., Robinson,C.M.,
            Nau,G.J. and Xavier,R.J.
  TITLE     Human leucine-rich repeat proteins: a genome-wide bioinformatic
            categorization and functional analysis in innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 108 Suppl 1 (Suppl 1), 4631-4638 (2011)
   PUBMED   20616063
REFERENCE   8  (bases 1 to 6376)
  AUTHORS   Sakabe,T., Shinomiya,T., Mori,T., Ariyama,Y., Fukuda,Y.,
            Fujiwara,T., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, MASL1, within an amplicon at 8p23.1
            detected in malignant fibrous histiocytomas by comparative genomic
            hybridization
  JOURNAL   Cancer Res 59 (3), 511-515 (1999)
   PUBMED   9973190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 17, 2025 this sequence version replaced XM_006253224.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32846.1,
                                           SRR26643288.55887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3588              JAXUCZ010000016.1  63333418-63337005   c
            3589-3715           JAXUCZ010000016.1  63263863-63263989   c
            3716-6376           JAXUCZ010000016.1  63248829-63251489   c
FEATURES             Location/Qualifiers
     source          1..6376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..6376
                     /gene="Mfhas1"
                     /note="multifunctional ROCO family signaling regulator 1"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
     exon            1..3588
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    576..578
                     /gene="Mfhas1"
                     /note="upstream in-frame stop codon"
     CDS             603..3749
                     /gene="Mfhas1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     malignant fibrous histiocytoma amplified sequence 1"
                     /codon_start=1
                     /product="malignant fibrous histiocytoma-amplified
                     sequence 1 isoform 1"
                     /protein_id="NP_001423493.1"
                     /db_xref="GeneID:306508"
                     /db_xref="RGD:1308812"
                     /translation="MAGKDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDSL
                     ESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAV
                     AELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD
                     VSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPED
                     ISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNL
                     SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSI
                     VELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQ
                     KELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLG
                     SKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCF
                     PTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLS
                     HLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVS
                     CRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDS
                     ARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRD
                     ASLLLHKLLLGTNGEGEGEGESFPTIAVPTPGQDPLRATQLHHYVEGFLLHGLLPAHI
                     IRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPH
                     AEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFA
                     YRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGL
                     HYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTP
                     TVISPCSKKNVGEKHRNQ"
     misc_feature    783..854
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    783..854
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    855..926
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    855..926
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <927..>1715
                     /gene="Mfhas1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <927..>1715
                     /gene="Mfhas1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    927..998
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    927..998
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    999..1067
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    999..1067
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1068..1136
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1068..1136
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1137..1274
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1137..1274
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1275..1343
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1275..1343
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1344..1412
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1344..1412
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1413..1481
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1413..1481
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1482..1550
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1482..1550
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1551..1619
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1551..1619
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1620..1682
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1620..1682
                     /gene="Mfhas1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1815..>2246
                     /gene="Mfhas1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    1815..>2246
                     /gene="Mfhas1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    1836..1859
                     /gene="Mfhas1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    1836..1859
                     /gene="Mfhas1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    1953..1955
                     /gene="Mfhas1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    1953..1955
                     /gene="Mfhas1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    1965..1973
                     /gene="Mfhas1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206741"
     misc_feature    1965..1973
                     /gene="Mfhas1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206741"
     misc_feature    2019..2030
                     /gene="Mfhas1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    2019..2030
                     /gene="Mfhas1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    order(2025..2030,2076..2081)
                     /gene="Mfhas1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206741"
     misc_feature    order(2025..2030,2076..2081)
                     /gene="Mfhas1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206741"
     misc_feature    2199..2210
                     /gene="Mfhas1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    2199..2210
                     /gene="Mfhas1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206741"
     misc_feature    2568..3308
                     /gene="Mfhas1"
                     /note="C-terminal of Roc, COR, domain; Region: COR;
                     pfam16095"
                     /db_xref="CDD:406489"
     misc_feature    2568..3308
                     /gene="Mfhas1"
                     /note="C-terminal of Roc, COR, domain; Region: COR;
                     pfam16095"
                     /db_xref="CDD:406489"
     exon            3589..3715
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..6376
                     /gene="Mfhas1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcttccc gatcgcgctc tcccagcgcc ggggacgcgg cgctcgcgct cccgcccgag
       61 ccgcggggaa acggagacaa ggagacgccg ccacctccgg cgccccggcc ctgctcccgc
      121 agcatgcccg ccgcggagcc gagcgccgcc ctcctcctgc agctagcgga ggcgacgccg
      181 ccggcctccg ggccgccgct gcgagggtag cggggccgga gtcggctact gaggcaaggc
      241 aaggcgggcg gagctggagg aggagcaggc atcctccgcg gcgcggcggg cggcggccct
      301 gctgcccggc gcgcccatgg cccgggagca cggagaatgc gagccgcgtt gcgcggccgc
      361 agccgagctc cgagccgctt gcccggagtc ccccaaagct gcctgcgtcg ctgccgctcc
      421 ccagctgcgg gctcccggcc actggctgtg ctaggaccca cagtcgccgg ccgcgcaggg
      481 gtggtggccc gggagcagcg ggagctagag ggcccgggag ctgggcgccg gccggagtcc
      541 agcgcggcat gcagctgcgg gctccggtac cggcgtgagg gttgtcggcg cgggctccgg
      601 ccatggctgg caaggacagt ggcaacctga agacggtgag gctgtggcgg gacgccgccc
      661 tgcgcgccag gaagctgcgg agcaacctgc gccagctcac gctcagctgc ccgggggcgg
      721 gaggcgactc actcgagtcc cccgacgccc cccagctggt gctgccggcc aacatcgggg
      781 acattgaggt gctgaacctg gggaacaacg gcctcgagga tgtgcctgaa ggtctggggt
      841 cagctctggg cagccttcgc gtcttggtct tgcgcaggaa ccgctttgcc cggctgcccc
      901 ctgcggtggc ggagctaggc caccacctta ccgaactgga cgtaagccac aaccggctaa
      961 ccatcctggg agccgaggtg gtgagcgccc taagggagct gcgcaaactc aacctgagcc
     1021 acaaccagct gccagccctg cctgcccagc tcggtgccct cgcccacctg gaggagctag
     1081 atgtcagctt caaccggcta gcgcatctgc cagattcctt ctcctgcctc aaccacctac
     1141 gtacccttga cgtggaccac aaccaactca ccgcctttcc ccagcagctg ctgcagctgg
     1201 ctgccctgga ggagctggac gtatccagca accggctgcg aggcctacct gaggatatca
     1261 gtgccctgcg tgccctcaag attctctggc ttagcggggc cgagcttggc actctgccca
     1321 gcggcttctg tgagctggcc agtttggaga gcctcatgtt agacaacaac gggctacagg
     1381 ctctgcccga cgagttcagc cgtctgcaaa ggctcaaaat gctcaacctt tcttccaacc
     1441 tcttcgagga gttccccgct gcgctgctgc ccctggctgg gctggaggag ctctacctta
     1501 gtcgcaatca gctcacctca gtgccctctc ttatcgccgg gctgggccgc cttctcacct
     1561 tgtggctgga taataaccgc atccgctacc tgccagactc cattgtggag ctgactggcc
     1621 tggaggagct ggtgcttcaa ggcaaccaga tcgctgttct gcctgacaac tttggccagc
     1681 tctcccgggt aggtttgtgg aaaatcaagg acaacccgct gattcagccc ccttacgaag
     1741 tctgcatgaa ggggatccct tatatcgcag cctaccagaa ggaactggct cattctcaac
     1801 cagcggttca gccccgtctc aagctgctcc tgatgggcca caaggctgcc ggaaagaccc
     1861 tgcttcgaca ctgcctcact gaggacaaag tggaaggagg gcaaggagga ggggacaagg
     1921 agaagagcta cctacctttc cctccccttg ggagtaaggg catcgaggtg accagctgga
     1981 ctgcggacgc ttcccggggc ttgcggttca ttgtgtatga cttagctggt gatgaaagct
     2041 acgaggtgat ccagcccttc ttcctctccc caggagccct atatgtgctc gtggtcaact
     2101 tggccaccta tgaacctcgt tgctttccta ctactgtggg ctccttcctg catcgggtgg
     2161 gggcccgtgt gcctcatgct gtggtgtgta ttgtgggcac acatgctgac ctgtgtgggg
     2221 agcgggagct tgaggagaag tgtctggata ttcaccgaca gattgccctg caggagaagc
     2281 atgatgcaga gggcctaagc catctagcca aggtggttga tgaggccctg gctcgggact
     2341 tcgagctacg ctctgccagt ccccatgcag cttactacgg tgtttcagac aagaaccttc
     2401 ggagacgcaa ggcccatttt cagtacctgc ttaaccaccg gctgcagatc ctctcgcccg
     2461 tgttgcctgt gagctgcagg gaccccctcc aactgcaacg ccttcgagac aagctgctct
     2521 ctgtagccga gcaccgggaa atctttccca acttacacag agtcctgcct cggtcctggc
     2581 aggtactgga ggagctgcac ttccagccac cccaggcaca acgtctgtgg ctaagctggt
     2641 gggactctgc ccgcttgggc ctgcaggcag gtctgactga ggaccggctc cagagtgccc
     2701 tttcttacct gcatgagagc ggcaaactgc tctattttga ggatagcccg gccctcaagg
     2761 agcacgtctt ccacaacctc acccgcctca ttgacatcct caatgttttt ttccagagag
     2821 atgcttcttt gctgcttcat aaactgctcc tagggaccaa cggagagggc gagggggagg
     2881 gggaaagttt ccccaccata gcagtgccca ctccgggcca ggacccactc cgggccaccc
     2941 agctccatca ttacgtggaa ggctttttgt tgcacgggct tctgccagct catatcattc
     3001 ggttgctgct caagcctcac gtccaggccc agcaggactt gcagctcctg ctggagctgc
     3061 tggagaagat gggactctgt tactgcctca ataaacccaa aggcaagcct ttgaacggct
     3121 ccgcagcttg gtacaagttc ccatgctacg tgcagaatga ggtgccccac gcggaggcct
     3181 ggattaatgg caccaaccta gccgggcagt cttttgtggc tgaacagttg cagatcgaat
     3241 acagttttcc ctttaccttc ccacctggat tgtttgcacg ttacagtgtt cagatcaaca
     3301 gccacgtggt gcacaggtcg gatgggaaat ttcagatctt tgcgtatcga gggaaagtgc
     3361 ccgtggtggt gagctacaga cctgccaagg gggtcctgca gccagacacc ctatccatcg
     3421 ccagccatgc gtcgctaccc aatatatgga ccgcatggca agccatcacc cctttggtag
     3481 aggaactgaa tgtcctactt caggaatggc ctggactaca ctacactgtg cacatcctct
     3541 gttctaagtg ccttaagaga gggtcgccaa atccacacgc tttcccaggg gagttgctga
     3601 gtcagcccag gccagaaggg gtggcagaga tcatctgccc caagaacggc agcgagcgcg
     3661 tgaatgtggc tttggtttac ccacctacac cgactgtgat cagcccttgt tccaagaaga
     3721 acgttggtga gaagcacaga aaccagtgac attcgtggct gtggaatttt catggcatta
     3781 acagagcatg ggaccgactg ggacatcttc tgcccctcac gagcctgcca tgctcccaag
     3841 cgccttctgg ggccccagag tgaaaccgtg caccgcatcg gggtgcttgc agaggaccct
     3901 tggaggggtt ggagggggct gggaagatgg ggacaaacat ggagcaaatg tttcacaacc
     3961 tgaacctcag aactgtgatc ctccaaggag agagctactt gaagaaaagg gaaaaaaaaa
     4021 gttaacaggc ttctcaggga ttgtgacttc tgtgtacaca tgagccataa agctccaggt
     4081 caggcggcag tatttagagc actcagattt cagttctgtt caatgtgaag gagggatcaa
     4141 ctgacgttca ccgctgtccc gtaactagtg taagatatgt atatgttaat ctttattttt
     4201 ataatatgca aatacattta aatttataca gttttggcgc ttctagcatt agttaacact
     4261 gggtgcaata ttctgcatga gaactgtgcc aagacggggc tgatgcttct agtgtcagac
     4321 ctttggttct tttcgttgcc ctttagccca cctgcttgac tgaaaaggac agagaaagct
     4381 tctccctgtc agtccgtcca ggggtaggtg caagaattct aataaccgcc aggagcgttc
     4441 agcccattgg cagagtcccc tcccatcttt tcagtgcaca ccctgcttgc tagtcactgg
     4501 acatggtggt agaatgatga ctattctgtc ccttcacatc accactactg gggcagaggg
     4561 acatcctaga ggccaaatga ggtgaagaat ctctgagaac ctgattcttg gagcaacttg
     4621 cgataatctg agttcagttc taaatcttgt agccgttcta ctgctatgca cccccctctc
     4681 cctgaccccc cagcacagtg tgcatgagtt agcagggccc tctgtgaact ctccatctga
     4741 ctattggcct tcctggagga acatccgttt cacggaactc catccctcat tggctgttta
     4801 ttcatacaga gccacttgga ggaagtctgc agccaaggtc ctagtagagc ccttgttttg
     4861 aaacctctag gaggtaaaca tttaaaaaca aactccacac actgctctcc agtggcctcc
     4921 tagttaggac caaacagcct ttgctgcagt agagacgcag tctctgaaga acgtgaaggc
     4981 ctctgtttac atctgcctct tccgtgtgtt gacaggaagc atgtaaaact gactgttccc
     5041 cacaagaaag gtgtgtcagc tggtcttact ctgtcgcctg cattctgaag tatcgattct
     5101 tagaatgcca cagcccacac cgtcaccaca aatctttaag agaaatgcaa gcaggtcact
     5161 gcgctcttga gaaattacag actgattcgt gttggatctg ttcagttgac ttcactgccc
     5221 ccagaggccg ctctgtggag gcaatctctc agaaatcaga atctagtggg gattgtctct
     5281 cttttatgtt tcgaatactt gaacacggca agtccagttt taaaaatttc tcttaccttt
     5341 cagaacacag ttgcaggatg ggtgagaatc tggttgatct cttctgtcat agttctcatg
     5401 tgtgtgtgtg tgcaagtgtg aaccgaacag tttgcatttc tattgcttcg tagaccactg
     5461 aattattggg caatagtttt ttgtttttgt tttttattaa ttggcaccag acagttctga
     5521 aactgtcaag tcagcaaagt ccaactagct ttacaatgtc ctatatgact ttgggcttac
     5581 tccccagagg gccatgtcaa ataaaaataa ggccccttgg gtgagcatac cctgcaaatg
     5641 gttgctattt tcataaacac agatgcccgt gttctgaatg cctgctactt tctgacaagt
     5701 gatgttacat gttgttatcc gaaccctaga gaagcaccga gaatgaggga accttggcgg
     5761 tcacatgtgt tgtggccaag gttggcacga tcagagggtc atgcacccga aagagctcca
     5821 gcaaactgtg agaacttgcc tcagtgtgtg ggggagaggg ctgagataca gaaacacctc
     5881 tgcccaagaa gaatctcagc atctgtgtag gaaattctgt ttccttattt cacacccggg
     5941 aagactcagc ggccagccgc tgaggggccg cccatccgct aagcacaaga ggaatgcgtt
     6001 ctacccaagg agcccctcgc ctctcacacg cgctccaagt ttgttatggt ttctattctt
     6061 acaactcgtg gtatcaaaac catttcctgg gattgttgaa gtgctgccag agtaaatggt
     6121 ttcccccttc tttggaaaaa caaaaacaaa caaaaacaaa aacaaaaaaa ccccgacagt
     6181 gctcatattt gatgtgtgca ctggactctt ttgaatgaat aaagtggaag ggcttgatag
     6241 gattccagtg gagtgtgtgt tttttcatgc tgcagtctgt gaattgtaac tgtggtttcc
     6301 cggttcattg tcctaacggg gcagaaattt aaaaaaaaaa aaaaatcaat aaaaacacaa
     6361 tgaaatggtt aagcca
//
LOCUS       NM_001436612            2509 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5),
            transcript variant 1, mRNA.
ACCESSION   NM_001436612 XM_006253322
VERSION     NM_001436612.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2509)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 18, 2025 this sequence version replaced XM_006253322.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079016.1, SRR26360186.1697656.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000016.1  73925752-73925871
            121-200             JAXUCZ010000016.1  73926790-73926869
            201-256             JAXUCZ010000016.1  73927485-73927540
            257-335             JAXUCZ010000016.1  73929777-73929855
            336-412             JAXUCZ010000016.1  73930126-73930202
            413-590             JAXUCZ010000016.1  73931687-73931864
            591-656             JAXUCZ010000016.1  73932826-73932891
            657-728             JAXUCZ010000016.1  73934031-73934102
            729-886             JAXUCZ010000016.1  73934279-73934436
            887-968             JAXUCZ010000016.1  73935273-73935354
            969-1105            JAXUCZ010000016.1  73939574-73939710
            1106-1295           JAXUCZ010000016.1  73941664-73941853
            1296-1391           JAXUCZ010000016.1  73946164-73946259
            1392-1587           JAXUCZ010000016.1  73947426-73947621
            1588-1678           JAXUCZ010000016.1  73957828-73957918
            1679-1895           JAXUCZ010000016.1  73958685-73958901
            1896-1982           JAXUCZ010000016.1  73973622-73973708
            1983-2097           JAXUCZ010000016.1  73974416-73974530
            2098-2260           JAXUCZ010000016.1  73981312-73981474
            2261-2314           JAXUCZ010000016.1  73983410-73983463
            2315-2509           JAXUCZ010000016.1  73993402-73993596
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2509
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..120
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2327
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; a disintegrin and metalloprotease domain (ADAM)
                     5; tMDC II; a disintegrin and metalloprotease domain 5;
                     disintegrin and metalloproteinase domain-containing
                     protein 5; transmembrane metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein II; a
                     disintegrin and metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5 isoform 1 precursor"
                     /protein_id="NP_001423541.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MFLLLLLVVHLNGLQAGQHPQKTILQTTVPEKISSPDVETDPEN
                     HMAYLITINENPHFIHLKKQSFITSTAVSYTYDRQDVRHSQSLSSLKNCNYNGYVAGF
                     PNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTY
                     SWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGF
                     INTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFV
                     EHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCH
                     CTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRI
                     CGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLC
                     RKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKY
                     VRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQ
                     IRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLV
                     DFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSA
                     KQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVS
                     NTKMTTNEGSTLH"
     sig_peptide     66..113
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    141..491
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    141..491
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    618..1199
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    618..1199
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     Region: Reprolysin; pfam01421"
                     /db_xref="CDD:426256"
     misc_feature    1260..1484
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1260..1484
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="Region: Disintegrin; pfam00200"
                     /db_xref="CDD:459709"
     misc_feature    1494..1925
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     misc_feature    1494..1925
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM Cysteine-Rich Domain; Region: ACR; smart00608"
                     /db_xref="CDD:214743"
     exon            121..200
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            201..256
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            257..335
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            336..412
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            413..590
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            591..656
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            657..728
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            729..886
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            887..968
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1105
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1295
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1391
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1587
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1678
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1895
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1982
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2097
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2260
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2314
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2509
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgccctc cccacctgcc tggccagatg ctcctcagct aagctccagg accaccaagg
       61 gagccatgtt cctccttctt ttgctggttg tgcatcttaa tgggctgcag gcaggccaac
      121 atcctcagaa aaccatcctg caaacaactg ttcctgaaaa gatctcatca ccagatgtgg
      181 aaacagatcc agaaaaccat atggcttatc ttattacaat aaatgaaaac ccccatttca
      241 tccatcttaa aaagcaatcg tttataactt caactgcagt gagttataca tatgacagac
      301 aagatgttcg gcattctcag tctttgtcat ctctgaaaaa ttgcaattac aacggatacg
      361 ttgcaggttt tccaaattct atcgtgtcgc tcaccgtttg ctcaggactc aggggaatga
      421 tacaatttga aaatgtctcc tatggaatcg aacctgtgga aaccctgtca ggatttatac
      481 acgtgatcta tgagaacaca aatcagcaag ctaagattcc tgacttagga gagaatcaga
      541 cgtacagttg gtctgatgaa ttagattatc aattccgaag caacatgaag aaatccggat
      601 ttgccgtgtt acggccacgg tacattaaga cggatatcgt cgtggataaa aagctgtttg
      661 attacatggg ctccgacact agggtcgtgc tacagaaagt cattcagatc atcggtttca
      721 ttaacactat gttctccaag ttgaaactga cggttttaat aaattccgtt gaaatctggt
      781 cgaaggaaaa cagaattgat ttcccagagg cacctgaaaa cttactggtc cagtttttac
      841 attggaaaca taagtataga ccgcagcaca tttcatactt actggcattt gtggagcatc
      901 ctgcttccac gggagccctc tatccgggga atctgtgcaa accgatctat ggtgctgcca
      961 ttgccctgta ccctaaaggt ttgtcactag agtcctacag cgtcatcgtc ctacaactac
     1021 tgagcatcgg tataggctta acctatgaca acgctgacag ctgccactgt acaggagacg
     1081 tctgcctgat gacgcccaag gcaatatatt ctgggggtgt gaaggacttc agtacttgta
     1141 gcttggatga cttcaaatac ctgtcaacac aagaccttga atgtctccag gacttgccta
     1201 tggaaagaca aaagaagaag ccttccaggc caaggagaat ctgtggcaac gggatattgg
     1261 aaatgaacga gcagtgtgac tgtggcactt tgaagaattg tacacacaaa aaatgctgtg
     1321 accccatgtc gtgccgactg aagtccaaag ccgtgtgtgg ctccggggag tgctgtggtc
     1381 aggactgcaa ggtaaaaccg gttaatgtac tctgtagaaa gtcgaagaat gaatgtgact
     1441 ttgaggagta ctgtaacgga aatgacgctt actgtgtccc tgacacgttc gcacgcaacg
     1501 ggcagtactg cgactcaggg caagccttct gctacagtgg tctttgtatg acgagtaata
     1561 atcaatgcat gaacttgctc gggaaatatg tgagaggagc ttccttcgca tgctatgaag
     1621 agttcaattc cagaaacgat agatttggca actgtattag aaagttttgt agtttcgaaa
     1681 attctctctg tgggaagttg gtctgtacct ggccattcaa gaggctgctc atgaaagaca
     1741 atatgtctgc ggcttatgga caaatccgag acgatttatg catctctctg tataaaggag
     1801 ggaggccact taagacaaca ttgtcaacat attccgatat gtcagaaaga gacgaaacat
     1861 ttgtaaaaga cggcacaatc tgtggtcctg atatgttttg tttggaaaca cagtgcaaag
     1921 aaacgagatt tttggtggat tttcaacagt gcaatacttc ccgagattgc aatgaccatg
     1981 gggtttgcaa caactttaat cattgtcatt gtgataaagg atataaccct ccctattgtg
     2041 agtcagtaaa aggacagttt ggaagcattg atgacggcca caaatattac attgacgaag
     2101 ggaaaagcgc taagcagcag aatcgtggta ttcacccaaa gcagcaactc cagcttattc
     2161 tgtatataac gctgcccttg attatgatta tctcggctgt atttataaag caaagcaaac
     2221 tgagtcggct atgcggcaga gaaagaagcg aaggcaccag ctgtataaca gaagacagtg
     2281 tgagtaacac caagatgacc accaacgaag gaagcaccct tcactaacca cctcaagtgt
     2341 tgccacccaa aaagaagata gtctggatta accacgggaa actggcattt tgagcaagag
     2401 gaaggggaaa aaaccacccc caaaccaacc cacagcttct ctcccacttc tgcagagata
     2461 aatgaggact ctaaaccatg aactaataaa tcagcggtgg ctgaacaaa
//
LOCUS       NM_175765               3231 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            transcript variant 1, mRNA.
ACCESSION   NM_175765 XM_063287634
VERSION     NM_175765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Mar 21, 2025 this sequence version replaced
            XM_063287634.1, NM_175765.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.28334.1,
                                           SRR26643287.13454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000005.1  102925051-102925194 c
            145-354             JAXUCZ010000005.1  102924499-102924708 c
            355-431             JAXUCZ010000005.1  102920995-102921071 c
            432-570             JAXUCZ010000005.1  102914210-102914348 c
            571-675             JAXUCZ010000005.1  102911917-102912021 c
            676-738             JAXUCZ010000005.1  102910548-102910610 c
            739-832             JAXUCZ010000005.1  102904851-102904944 c
            833-908             JAXUCZ010000005.1  102903950-102904025 c
            909-1134            JAXUCZ010000005.1  102902031-102902256 c
            1135-1253           JAXUCZ010000005.1  102900532-102900650 c
            1254-1309           JAXUCZ010000005.1  102898250-102898305 c
            1310-1380           JAXUCZ010000005.1  102897525-102897595 c
            1381-1482           JAXUCZ010000005.1  102897223-102897324 c
            1483-1696           JAXUCZ010000005.1  102896915-102897128 c
            1697-1808           JAXUCZ010000005.1  102895418-102895529 c
            1809-3231           JAXUCZ010000005.1  102892929-102894351 c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..3231
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..144
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    223..225
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="upstream in-frame stop codon"
     CDS             283..1869
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="isoform 1 is encoded by transcript variant 1; PC4
                     and SFRS1-interacting protein; supercoiled DNA binding
                     protein 75; PC4 and SFRS1 interacting protein 2; lens
                     epithelium-derived growth factor; PC4 and SFRS1
                     interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein isoform 1"
                     /protein_id="NP_786941.2"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEQQTKDEGKKPE
                     VKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHT
                     EMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEE
                     ANKTKDQGKKGPNKKLEKEQTGTKSLNGGSDAQESNHPQHNGDSAEESKDSREAGSKT
                     KTPGEEREAEVSLKESTLDN"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    295..558
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP domain found in PC4 and SFRS1-interacting
                     protein (PSIP); Region: PWWP_PSIP; cd20151"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(322..324,328..333,337..339,496..498,502..504)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    order(334..336,343..345,412..414)
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    337..348
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PWWP sequence motif; other site"
                     /db_xref="CDD:438979"
     misc_feature    538..1323
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <550..1851
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <550..1851
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    586..588
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    595..597
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    598..600
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    625..627
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99JF8; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    646..648
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    703..705
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    718..750
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    808..810
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    895..897
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1090..1092
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1096..1098
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1102..1104
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1294..1527
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Integrase-binding domain (IBD).
                     /evidence=ECO:0000250|UniProtKB:O75475"
     misc_feature    1321..1626
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Lens epithelium-derived growth factor (LEDGF);
                     Region: LEDGF; pfam11467"
                     /db_xref="CDD:463284"
     misc_feature    1321..1626
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Lens epithelium-derived growth factor (LEDGF);
                     Region: LEDGF; pfam11467"
                     /db_xref="CDD:463284"
     misc_feature    1576..1578
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1585..1587
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1603..1605
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1612..1866
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="propagated from UniProtKB/Swiss-Prot (Q812D1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1840..1842
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     misc_feature    1855..1857
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75475; propagated from
                     UniProtKB/Swiss-Prot (Q812D1.1); phosphorylation site"
     exon            355..431
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            571..675
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            676..738
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            833..908
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1134
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1253
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1309
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1380
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1482
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1696
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1808
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..3231
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacatcg gcggcagtgg cggtggcggt tgcagctcgg agccgttgag acgcctctgc
       61 ggcagctggt ggcgcaggtg gccggcgtgg acgtgggcag aagcggccag cgcgccccgc
      121 agccccagcg ccaccgcccg gcaggcgcgt cgggacaccc cgaggcatcc tcccccgccc
      181 gcgggcccgc cagtcccagc tcgcgtcggt gctcgcatct actgatcgcg gctgcgctgc
      241 tcccccttct ggtcttggga ctcccggcgt cgcccctcaa acatgactcg cgatttcaaa
      301 cctggagacc tcatcttcgc caagatgaaa ggttatcctc attggccagc tcgagtagat
      361 gaagttcctg atggagctgt aaaaccaccc acaaacaaac tacccatttt cttttttgga
      421 acccacgaga ctgctttttt aggaccaaag gacatatttc cttattcaga aaataaggaa
      481 aagtatggca aaccaaataa acgaaaaggt tttaatgaag gattgtggga gatagataac
      541 aatccaaaag tgaaattttc aagtcaacag gtatcaacca aacagtcaaa tgcatcatct
      601 gatgttgaag cggaagaaaa agaaactagt gtttcaaagg aagatactga tcaggaagaa
      661 aaagccagca atgaagatgt gactaaagca gctgacataa ccactccaaa agctgccagg
      721 cgaggaagaa agagaaaggc tgaaaaacaa gtagacactg aagaggcagg agtggtgact
      781 gcagcgaccg cttccaatgt gaaagcaagt cctaagagag gacggcctgc agctactgaa
      841 gtcaagattc caaaaccaag aggcagacct aaagtggtaa aacagccctg tccgtcagaa
      901 agtgacatgg ttattgatga agacaaaagt aaaaaaaagg ggccagagga aaaaccaccc
      961 aaaaagcagc ttaaaaagga ggaagaaggc caaaaggaag aagagaagcc aagaaaagaa
     1021 ccagataaga aagaggggaa gaaagaagtc gaatctaaac ggaaaaattt agctaaacca
     1081 ggggttacgt caacctctga ttcagaagaa gatgatgatc aagaaggtga aaagaagaga
     1141 aagggtggaa gaaacttcca ggctgctcac aggaggaaca tgctaaaagg ccaacatgag
     1201 aaagaagctg cagatcggaa acgcaagcag gaggaacaaa tggagactga gcagcagact
     1261 aaagatgaag gaaagaagcc agaagttaag aaagtggaga agaagcgaga aacatcaatg
     1321 gattctcgac ttcaaaggat acatgctgaa attaaaaatt cactcaaaat tgataatcta
     1381 gatgtgaaca gatgcattga ggcactggat gaactcgctt cacttcaggt aacaatgcaa
     1441 caagctcaga aacacacaga gatgatcaca accctgaaga aaatccggcg gttcaaagtc
     1501 agtcaagtta tcatggagaa gtctacaatg ttgtataaca agtttaagaa tatgtttttg
     1561 gttggtgaag gggattccgt catcacccaa gtgctaaaca aatctcttgc tgaacaaaga
     1621 cagcatgagg aagcaaataa aaccaaagat caagggaaga aagggccaaa caaaaagcta
     1681 gaaaaggaac aaacaggtac aaagagccta aatggaggat ctgatgctca ggaaagtaat
     1741 catccacaac ataatggtga cagtgcggaa gaaagcaaag acagccgtga ggccggcagt
     1801 aagacaaaga cacctggaga agagagagag gctgaagtat ctctgaagga gtctacccta
     1861 gataactagg tctgcagact tcagatgtaa agagtgtgag aagtctgttg tgagtggctt
     1921 catttgaaat acttaggctg ctgaaaggtt taaagtttta taagcatagg ttttgatgtt
     1981 taagtagttg ggggatagaa aaacccttta tatttgtgta aaagtcaatt attgctaatt
     2041 ttctgtgtgc agtattaaca gctccgccat ctagtttgag taaggaaacc tacttagaaa
     2101 ggttaacctg ctttatagac atgactgtag tgaatttttg gttagtgtgt caatgtgtaa
     2161 ttagtagtag ggcagttaca ttttaaaact gctacttgta taaatctttc ctcttttccc
     2221 aaatactgtg cgttttgtgc atagttttta caaatattgg atttaccaga ctgtcttttc
     2281 actgtgtggg tgttttagaa gttgagcatt tttatggatg ataaaatgaa tgttacttct
     2341 aagtactcac tcccttttat caacagttat aacctcagtc cattgtgcta cattagcgtg
     2401 cctctttgta ataatgtgta gtatgacagc tagatgccta ttgggttgtt atagaaggta
     2461 caaatttgtt tacttttaaa agtaatttag ttttaggact gggatttcag tggtgttaga
     2521 actagagaga acagactggt tatatataca tataggaagt ccatctacaa tcctttataa
     2581 aggtactaat cacacaaacc taaaattagt ttgttttaat cttatactca ttaaggtgtg
     2641 tttttttttc tttctttttt aattagaatc aatccatgat gcttataagt aataaataag
     2701 gaaattaacc taattgaaga catggccata ttgtaatggg atttttgttt ctctatcaaa
     2761 cataatcaga tgattacaga aaaaacaaac atcagttgtt ccaaggtagt aaccagatag
     2821 tccatataca caaacatgga ctattgctct gttaaattaa ggcataacat ttcaaagata
     2881 ttctgagtaa tcaggtcagt tgttggtctc tggtaggtag aaaagtttat ccttatgctt
     2941 tgaaattttg taggaaggtg acttaatacc agtgtttctg tgcgatacga ttaaatatgt
     3001 tcttgatttc tcagatagtt atttttacct atgtaaaact ttaattactc caattggact
     3061 ttgctttgat agctcttaca attcactact gttttgagca agtgctgtac attatttacg
     3121 ccagtcttct gttttgtcct tagtacattt ttaacttgga caaaaattat cctagttaag
     3181 ccataagtgt caatgtgtaa attgttttaa ttaaaaggtt tttctaccaa a
//
LOCUS       NM_001437053            1967 bp    mRNA    linear   ROD 28-MAR-2025
DEFINITION  Rattus norvegicus glomulin, FKBP associated protein (Glmn),
            transcript variant 2, mRNA.
ACCESSION   NM_001437053 XM_008769922
VERSION     NM_001437053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Krummrei,U., Baulieu,E.E. and Chambraud,B.
  TITLE     The FKBP-associated protein FAP48 is an antiproliferative molecule
            and a player in T cell activation that increases IL2 synthesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2444-2449 (2003)
   PUBMED   12604780
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Brouillard,P., Boon,L.M., Mulliken,J.B., Enjolras,O., Ghassibe,M.,
            Warman,M.L., Tan,O.T., Olsen,B.R. and Vikkula,M.
  TITLE     Mutations in a novel factor, glomulin, are responsible for
            glomuvenous malformations ('glomangiomas')
  JOURNAL   Am J Hum Genet 70 (4), 866-874 (2002)
   PUBMED   11845407
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Grisendi,S., Chambraud,B., Gout,I., Comoglio,P.M. and Crepaldi,T.
  TITLE     Ligand-regulated binding of FAP68 to the hepatocyte growth factor
            receptor
  JOURNAL   J Biol Chem 276 (49), 46632-46638 (2001)
   PUBMED   11571281
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Chambraud,B., Radanyi,C., Camonis,J.H., Shazand,K., Rajkowski,K.
            and Baulieu,E.E.
  TITLE     FAP48, a new protein that forms specific complexes with both
            immunophilins FKBP59 and FKBP12. Prevention by the
            immunosuppressant drugs FK506 and rapamycin
  JOURNAL   J Biol Chem 271 (51), 32923-32929 (1996)
   PUBMED   8955134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 26, 2025 this sequence version replaced XM_008769922.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.45951.1,
                                           SRR26643294.49292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000014.1  2332497-2332539
            44-119              JAXUCZ010000014.1  2333232-2333307
            120-245             JAXUCZ010000014.1  2334272-2334397
            246-362             JAXUCZ010000014.1  2344614-2344730
            363-471             JAXUCZ010000014.1  2345623-2345731
            472-709             JAXUCZ010000014.1  2346975-2347212
            710-812             JAXUCZ010000014.1  2348675-2348777
            813-1000            JAXUCZ010000014.1  2350635-2350822
            1001-1054           JAXUCZ010000014.1  2357941-2357994
            1055-1085           JAXUCZ010000014.1  2358450-2358480
            1086-1175           JAXUCZ010000014.1  2358941-2359030
            1176-1217           JAXUCZ010000014.1  2359838-2359879
            1218-1291           JAXUCZ010000014.1  2359962-2360035
            1292-1376           JAXUCZ010000014.1  2362446-2362530
            1377-1483           JAXUCZ010000014.1  2363005-2363111
            1484-1547           JAXUCZ010000014.1  2363658-2363721
            1548-1671           JAXUCZ010000014.1  2373644-2373767
            1672-1754           JAXUCZ010000014.1  2374875-2374957
            1755-1967           JAXUCZ010000014.1  2375162-2375374
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1967
                     /gene="Glmn"
                     /note="glomulin, FKBP associated protein"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
     exon            1..43
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            44..119
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Glmn"
                     /note="upstream in-frame stop codon"
     CDS             81..1871
                     /gene="Glmn"
                     /note="FKBP associated protein"
                     /codon_start=1
                     /product="glomulin"
                     /protein_id="NP_001423982.1"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
                     /translation="MAVEELQCIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQ
                     LLEIIQDEKNKTIIKTMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELL
                     LGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSAGLALSTLWSQLSLLPVP
                     HSEEQIQADDYGLCQCCRALIEFTKPFVAEVASDKEDPANTKLKDELLKFCFKSLKCP
                     LLTAQFLEQSEEVGNDPFRCFASEIIGFLSQIGYPVPQIILNHGRKKRTWDYLEFEEE
                     EDRQLADSVAALTYLVFVQGIGTDQLPMVLSPSYLLQLNMEHIEVLLQRTEQSVYSKG
                     LELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKTGLAMLQLYID
                     KLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSYKKTHNRWFAGAQLTSLLDL
                     VLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLQPLH
                     VGLNMSKAHYEAEIKNSQQNSQAASMCKSVCSVTVGGEEIPTMPPEMQLKVLHSALFT
                     FDLIESVLARVEELIEIKSKSTSEENAGMK"
     misc_feature    81..1652
                     /gene="Glmn"
                     /note="Uncharacterized protein family, YAP/Alf4/glomulin;
                     Region: Kinetochor_Ybp2; pfam08568"
                     /db_xref="CDD:400745"
     misc_feature    81..1652
                     /gene="Glmn"
                     /note="Uncharacterized protein family, YAP/Alf4/glomulin;
                     Region: Kinetochor_Ybp2; pfam08568"
                     /db_xref="CDD:400745"
     exon            120..245
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            246..362
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            363..471
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            472..709
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            710..812
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1000
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1054
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1085
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1175
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1217
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1291
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1376
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1483
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1547
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1671
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1754
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1967
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtggaga cggagggcaa gaagcaggcg cgtggactgg cggttcattt cagcatcaaa
       61 actaggaaaa gtaattagga atggctgtgg aggaacttca gtgcataata aaaagatgtc
      121 aaatcctaga agagcatgat tttaaagaag aagattttgg cctctttcag ctagcaggcc
      181 aaagatgcat tgaagatggg tatataaacc agctgctaga gattattcaa gatgaaaaga
      241 acaagaccat cattaagact atggggtgga atcttgttgg tcctgttgtc cgatgcctcc
      301 tgaggggcag ggaagaggat aaaagagaag agtgttttct gatctttgat ttgctggtga
      361 agttgtgtaa tccaaaggaa ttgttgttgg gtttgcttga actcattgaa gagccctccg
      421 ggaaacagat atctcaaatt attcttcttt tactgcaacc attacagaca gttattcaga
      481 aacttcctaa caacaaggca tactcggctg gattagcatt gtccacgctc tggagtcagc
      541 tgtctcttct tcctgtccca cactcagaag aacaaataca ggcagatgac tatggccttt
      601 gtcagtgttg cagggccttg atagagttca cgaaaccctt tgtggcagaa gttgctagtg
      661 ataaagaaga cccagcaaac acaaagctga aggatgaact actgaaattc tgtttcaaaa
      721 gcttgaaatg ccctttgctg acagcacaat tcctcgaaca gtctgaagaa gttggaaatg
      781 accctttccg gtgttttgca tctgaaataa taggattttt atcacaaatt ggatatcctg
      841 tcccccaaat tattcttaat catggaagga aaaaaaggac ttgggattac cttgaatttg
      901 aagaagaaga agacagacaa ctggcagact ctgtggctgc tctgacatac ctagtctttg
      961 ttcagggcat cggtaccgac cagcttccca tggtcttaag cccttcatac cttttgcagt
     1021 tgaacatgga gcacattgaa gtgcttctgc aaagaacaga acagtctgtt tactccaaag
     1081 gcttggaact gctggagact agcttattga gattagaaga caacagccta tgttatcagt
     1141 acctagaaat caagagtttc cttgctgtgc ctcagggctt agtcaaagtc atgacactct
     1201 gtcccattga gacactgagg aaaacagggt tagccatgct tcagctgtac atcgacaagt
     1261 tggactccca aggcaaatac acattattta ggtgcttact aaatacgagt aatcactcag
     1321 gtgtggaagc ctttgtaatt caaaatatca aaaatcagat tgatttatca tataagaaaa
     1381 cccataacag gtggtttgca ggcgcacagc tgacctctct gttagacctg gtcctgtccc
     1441 tccctgaggg cgctgagaca gatttactgc agaactcaga ccggattatg gcttcactaa
     1501 atttgttgag gtatttggtt atcaaagata atgaagatga caaccaaact ggattatgga
     1561 cagagcttgg aaagattgaa aataactttc tacagccact tcatgtagga cttaatatgt
     1621 caaaggcaca ttatgaagca gagattaaaa acagccaaca aaatagccaa gctgcctcaa
     1681 tgtgtaaaag tgtttgttct gtgactgtag gcggagaaga aatccccact atgcctcctg
     1741 agatgcagct taaggtctta cattccgccc tcttcacatt cgacttgatt gaaagtgtcc
     1801 tggctcgagt cgaagaactc attgaaatca aatcaaagtc tacctctgag gaaaacgctg
     1861 ggatgaagta aaagctctac ttcatgaata aaaaccaata aaatgccatt tttcattata
     1921 gtttatactg ccataaaata gttgcagaaa ttttactaca agaaaaa
//
LOCUS       NM_001437154            1743 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus galactose-3-O-sulfotransferase 1 (Gal3st1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437154 XM_006251382
VERSION     NM_001437154.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Honke,K., Hirahara,Y., Dupree,J., Suzuki,K., Popko,B.,
            Fukushima,K., Fukushima,J., Nagasawa,T., Yoshida,N., Wada,Y. and
            Taniguchi,N.
  TITLE     Paranodal junction formation and spermatogenesis require
            sulfoglycolipids
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4227-4232 (2002)
   PUBMED   11917099
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Hirahara,Y., Tsuda,M., Wada,Y. and Honke,K.
  TITLE     cDNA cloning, genomic cloning, and tissue-specific regulation of
            mouse cerebroside sulfotransferase
  JOURNAL   Eur J Biochem 267 (7), 1909-1917 (2000)
   PUBMED   10727929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006251382.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.2939026.1,
                                           SRR22399484.1421061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000014.1  83094293-83094481
            190-332             JAXUCZ010000014.1  83107587-83107729
            333-1743            JAXUCZ010000014.1  83108582-83109992
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1743
                     /gene="Gal3st1"
                     /note="galactose-3-O-sulfotransferase 1"
                     /db_xref="GeneID:683713"
                     /db_xref="RGD:1583379"
     exon            1..189
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..332
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1473
                     /gene="Gal3st1"
                     /EC_number="2.8.2.11"
                     /codon_start=1
                     /product="galactosylceramide sulfotransferase"
                     /protein_id="NP_001424083.1"
                     /db_xref="GeneID:683713"
                     /db_xref="RGD:1583379"
                     /translation="MTLLPKKPCKSKAKGLVLGALLTSFLLLLYSYVVPPLYPNLAFT
                     TSEAAAPCSPVPNEPVAATPANGSAGGCQPRRDIVFMKTHKTASSTLLNILFRFGQKH
                     ELKFAFPNGRNDFHYPSYFARSLVQDYRPGACFNIICNHMRFHYEEVRGLVRPGATFI
                     TVIRDPARLFESSFHYFGSVVPLTWKLSSRDKLAEFLQDPDRYYDPSSYNAHYLRNLL
                     FFDLGYDSSLDPGSPRVQEHILEVERRFHLVLLQEYFDESLVLLRELLCWDLEDVLYF
                     KLNARRDSPEPRLSGELYRRATAWNLLDVRLYRHFNASFWRKVEAFGRERMASEVAKL
                     RRANEHMRSICIDGGQAVDAEAIQDSAMQPWQPLGIKSILGYNLKKSIGPQHEQLCRR
                     MLTPEIQYLSDLGANLWITKLWKFFRDFLRW"
     misc_feature    211..1425
                     /gene="Gal3st1"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     cl22970"
                     /db_xref="CDD:451469"
     misc_feature    211..1425
                     /gene="Gal3st1"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     cl22970"
                     /db_xref="CDD:451469"
     exon            333..1743
                     /gene="Gal3st1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggcctca cctggccgag agtattgaga acgggtgcgg cagccgctgc ggcggcgggg
       61 cgggggcatg gaccaggcct gccagcgcgc cgggtcccgg cgagtgcgcc ccgccgccca
      121 gtgagcgcca cggcggcggg ggccgggacc gacccctgcc acccggagcc caaggagaac
      181 agggccaagt ggtttcctga gatgactcta ctgccgaaga agccctgcaa gtccaaggcc
      241 aaggggctag tgctgggggc tctcttaacc agtttcctat tgctgctgta ctcctatgtg
      301 gtacctccac tgtatcccaa cttggccttc acgacctcag aggctgcagc gccctgctcc
      361 cctgtcccca atgagccagt ggcagccact cccgccaacg gctctgccgg agggtgccaa
      421 cctcggcggg atattgtgtt catgaagacg cacaagaccg ccagcagcac gctgctcaac
      481 atcctcttcc gcttcggcca gaagcatgag ctcaagttcg ccttccccaa tggccgcaac
      541 gacttccact acccatcgta cttcgcacga agcctggtgc aggactaccg gccaggggca
      601 tgcttcaata tcatctgcaa ccacatgcgc ttccactacg aggaggtgcg cgggctggtg
      661 cggccgggtg ctaccttcat cacggtcatc cgcgaccccg ctcgtctctt cgagtcctcc
      721 ttccactact ttgggtccgt ggtgccgctc acttggaagc tgtcgagtcg cgacaagctg
      781 gctgagttcc tgcaggatcc cgatcgctac tacgacccaa gcagctacaa cgcgcactac
      841 ctccgtaacc tgctcttctt cgacctgggc tacgacagca gcctggatcc gggcagcccg
      901 cgcgtgcagg agcacatcct ggaggtggag cgccgcttcc acctggtgct gctgcaggag
      961 tacttcgacg aatccctggt gctgctccgg gagctgctgt gctgggacct ggaggacgtg
     1021 ctgtacttca agctcaacgc gaggcgcgac tcgccggagc cgcggctctc aggcgagctg
     1081 taccgccgag ccaccgcctg gaacctgctg gatgtgcgtc tctaccgcca cttcaacgcc
     1141 agcttctggc gaaaggtgga ggccttcggg cgcgagcgca tggcgagcga ggtagccaag
     1201 ctgcgccgag ctaacgagca catgcgcagc atctgcatag atggcggcca agcggttgat
     1261 gcggaggcca tccaggactc cgccatgcag ccctggcagc ccctgggcat caagtccatc
     1321 ctgggttaca acctcaagaa gagcatcggg ccacaacacg agcagctctg ccggcgcatg
     1381 ctcacgcccg agatccagta cctgtctgac cttggtgcca atctctggat caccaagctc
     1441 tggaagttct ttagggactt tctaagatgg tgatgtactc ggcccacctc ctgtttggct
     1501 tcctactgca gaaaggccgg gcagggaaac tttggcacct agccctcccc agccacgcct
     1561 agtgccatct ggggtcccta gggtcatagc tatccgagac tggtctctct gcacgagagg
     1621 gcctaactga gaggtattta actaattatg gcattttaaa aaaatttaaa tcccctttat
     1681 ctccagcctc tacttacaag gggagactca gaagtaaaga aattttatgc gtttttttgt
     1741 taa
//
LOCUS       NM_001437162            7493 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 2 (Arap2), transcript variant 2, mRNA.
ACCESSION   NM_001437162 XM_039091930
VERSION     NM_001437162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7493)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039091930.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.54667.1,
                                           SRR26360176.2079258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000014.1  50921771-50922075
            306-439             JAXUCZ010000014.1  50922347-50922480
            440-1477            JAXUCZ010000014.1  50936567-50937604
            1478-1536           JAXUCZ010000014.1  50962703-50962761
            1537-1613           JAXUCZ010000014.1  50963754-50963830
            1614-1705           JAXUCZ010000014.1  50964697-50964788
            1706-2056           JAXUCZ010000014.1  50966559-50966909
            2057-2126           JAXUCZ010000014.1  50982541-50982610
            2127-2247           JAXUCZ010000014.1  51002380-51002500
            2248-2426           JAXUCZ010000014.1  51010782-51010960
            2427-2542           JAXUCZ010000014.1  51024600-51024715
            2543-2742           JAXUCZ010000014.1  51026673-51026872
            2743-2828           JAXUCZ010000014.1  51031532-51031617
            2829-3011           JAXUCZ010000014.1  51032410-51032592
            3012-3186           JAXUCZ010000014.1  51032997-51033171
            3187-3321           JAXUCZ010000014.1  51033589-51033723
            3322-3466           JAXUCZ010000014.1  51038012-51038156
            3467-3569           JAXUCZ010000014.1  51039060-51039162
            3570-3768           JAXUCZ010000014.1  51039809-51040007
            3769-3832           JAXUCZ010000014.1  51040179-51040242
            3833-3996           JAXUCZ010000014.1  51059939-51060102
            3997-4209           JAXUCZ010000014.1  51065124-51065336
            4210-4315           JAXUCZ010000014.1  51071169-51071274
            4316-4463           JAXUCZ010000014.1  51074919-51075066
            4464-4532           JAXUCZ010000014.1  51076615-51076683
            4533-4607           JAXUCZ010000014.1  51078985-51079059
            4608-4725           JAXUCZ010000014.1  51082583-51082700
            4726-4854           JAXUCZ010000014.1  51089683-51089811
            4855-4982           JAXUCZ010000014.1  51100777-51100904
            4983-5065           JAXUCZ010000014.1  51107197-51107279
            5066-5101           JAXUCZ010000014.1  51108259-51108294
            5102-5165           JAXUCZ010000014.1  51110163-51110226
            5166-5300           JAXUCZ010000014.1  51116181-51116315
            5301-7493           JAXUCZ010000014.1  51118606-51120798
FEATURES             Location/Qualifiers
     source          1..7493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..7493
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 2"
                     /db_xref="GeneID:305367"
                     /db_xref="RGD:1306452"
     exon            1..305
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..439
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..1477
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    549..551
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="upstream in-frame stop codon"
     CDS             582..5669
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 2; centaurin, delta 1"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 2 isoform 2"
                     /protein_id="NP_001424091.1"
                     /db_xref="GeneID:305367"
                     /db_xref="RGD:1306452"
                     /translation="MSAVSEVNVDIQDFLMSINLEQYLLHFQEFGFYTVKDCTSINDN
                     VLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVYKTKNGSTPKEQHSAPSSSSNT
                     CIEFSDSVTVHRPGPAPSEMVTTNVLSEGNCHSSTSHDKLSLSSSDLPCPEEEICQNV
                     DSSQDYLFGRVNVKIDSLITQQAVEHTAGEEQTEKVNLVSEDSSKALNTNTECLPSVD
                     HPASETHCGNGTNGVLESFPPSPFFQFQGEMVVNELYVPSSPIHSPMRSRSKLVSRPS
                     RSFLLRHRPVPEIPGSTKSISGSYFRDRKSITTSAGKSLTLKDANEDNSTSIFPYGET
                     FLFQRLESSKKRSIKNEFWAHEDTVKEEAATSRNSILTKSSIYDSRKEKVSEDKVEDI
                     WIPREDKNNLPQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPL
                     SSTSENTDPSTIANAISPYACFYGSSAAKVKSGWLDKLSPQGKRMFQKRWVKFDGLSI
                     SYYNNDREMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISVLL
                     SALKSPSLTSQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKTEQDFKSGLGIT
                     IIPMNVANVKQIDRAVKQSFEIITPYRSFSFTADSEKEKQEWIEAVQQSIAETLSDYE
                     VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDA
                     SIWSNELIELFIVIGNKRANDFWAGNLKKDEEIQMDSPVDKRKIFITQKYKEGKFRKT
                     FLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHCTPYLLAKKAGQS
                     LQMEFLYHNKFSDFPQYDAHSEGGSSQEATQSTFLCDFLYQATASASRVSTEKKLLEE
                     TNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLTVHKEDFYLNTGPIFIFEIYLP
                     SERVFLFGAKTSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRK
                     GWFAMDKSSLCFCLQTQEAQEERMHLRRLQELTISTVVQNGEKVDVLLLVEKGRTLYI
                     HGYTKLDFTVWRNAIEKAAGTDGNTLQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIY
                     QKDGDPLSISELLESFKKDARSVKLRVGKHQLEDVTGVLKSFLSDIDDALLTKELYPY
                     WVSALDAQDEKQRTDKYRAFICSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLAL
                     VFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKNTQVSQ
                     AGDLLIEVFAERKEPDCSIIIRVSPVMEAEELTNDILAIKNILPTKGDIWATFEVIEN
                     EELERPLHYTENVLEQVLQWSSLAEPGSAYLVVKRFLTIDTIKQCREKSIKEGILKLK
                     EEPSKILSGNKFQDRCVVLRDGHLFIYKDPKSTKHEKMFPLRLMKFYLGVKKKMKPPT
                     SWGLTACSEKHHWHLCCDSLQAQMEWMASIFIAQHENDIWPPAGKERKRSITKNPKIG
                     GLPLIPIQHEKNATQARKNIEMARAELERLRLSERHDGDFTDSSLKDRASIIGYCLEH
                     KDEKLRNRARKHRSFNCLEDTEAEVPPGLPKGYKGLKTVKKTEDRNSKATLEPNNKLP
                     SKVIEELSVVLQRSRSHPKELPDEQTL"
     misc_feature    597..785
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="SAM domain of Arap1,2,3 (angiotensin
                     receptor-associated protein); Region: SAM_Arap1,2,3;
                     cd09490"
                     /db_xref="CDD:188889"
     misc_feature    597..785
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="SAM domain of Arap1,2,3 (angiotensin
                     receptor-associated protein); Region: SAM_Arap1,2,3;
                     cd09490"
                     /db_xref="CDD:188889"
     misc_feature    order(636..638,708..710,753..758,765..767)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="heterodimer interface EH [polypeptide binding];
                     other site"
                     /db_xref="CDD:188889"
     misc_feature    order(636..638,708..710,753..758,765..767)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="heterodimer interface EH [polypeptide binding];
                     other site"
                     /db_xref="CDD:188889"
     misc_feature    2019..2294
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 1; Region:
                     PH1_ARAP; cd13253"
                     /db_xref="CDD:270073"
     misc_feature    2019..2294
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 1; Region:
                     PH1_ARAP; cd13253"
                     /db_xref="CDD:270073"
     misc_feature    2322..2594
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 2; Region:
                     PH2_ARAP; cd13254"
                     /db_xref="CDD:270074"
     misc_feature    2322..2594
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain Pleckstrin homology (PH) domain, repeat 2; Region:
                     PH2_ARAP; cd13254"
                     /db_xref="CDD:270074"
     misc_feature    2607..2969
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGap with Rho-Gap domain, ANK repeat and PH
                     domain-containing protein 2; Region: ArfGap_ARAP2;
                     cd08856"
                     /db_xref="CDD:350081"
     misc_feature    2607..2969
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="ArfGap with Rho-Gap domain, ANK repeat and PH
                     domain-containing protein 2; Region: ArfGap_ARAP2;
                     cd08856"
                     /db_xref="CDD:350081"
     misc_feature    order(2667..2669,2676..2678,2727..2729,2736..2738,
                     2751..2753)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="arginine finger; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2667..2669,2676..2678,2727..2729,2736..2738,
                     2751..2753)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="arginine finger; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2667..2669,2676..2678,2727..2729,2736..2738)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:350081"
     misc_feature    order(2667..2669,2676..2678,2727..2729,2736..2738)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:350081"
     misc_feature    3243..3575
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3243..3575
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3612..3899
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3612..3899
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    3909..4448
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in ARAPs. ARAPs (also known
                     as centaurin deltas) contain, besides the RhoGAP domain,
                     an Arf GAP, ankyrin repeat ras-associating, and PH
                     domains. Since their ArfGAP activity...; Region:
                     RhoGAP_ARAP; cd04385"
                     /db_xref="CDD:239850"
     misc_feature    3909..4448
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in ARAPs. ARAPs (also known
                     as centaurin deltas) contain, besides the RhoGAP domain,
                     an Arf GAP, ankyrin repeat ras-associating, and PH
                     domains. Since their ArfGAP activity...; Region:
                     RhoGAP_ARAP; cd04385"
                     /db_xref="CDD:239850"
     misc_feature    order(4020..4022,4137..4139,4149..4151,4356..4358,
                     4365..4370,4416..4418)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239850"
     misc_feature    order(4020..4022,4137..4139,4149..4151,4356..4358,
                     4365..4370,4416..4418)
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="putative GTPase interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239850"
     misc_feature    4020..4022
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239850"
     misc_feature    4020..4022
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239850"
     misc_feature    4542..4835
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Ras-associating (RA) domain found in Arf-GAP with
                     Rho-GAP domain, ANK repeat and PH domain-containing
                     protein 2 (ARAP2); Region: RA_ARAP2; cd17227"
                     /db_xref="CDD:340747"
     misc_feature    4542..4835
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Ras-associating (RA) domain found in Arf-GAP with
                     Rho-GAP domain, ANK repeat and PH domain-containing
                     protein 2 (ARAP2); Region: RA_ARAP2; cd17227"
                     /db_xref="CDD:340747"
     misc_feature    4851..5186
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    4851..5186
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     exon            1478..1536
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1613
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1705
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..2056
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2126
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2247
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2426
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2542
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2742
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2828
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3011
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3186
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3321
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3466
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3569
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3768
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3832
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3996
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4209
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4315
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4316..4463
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4532
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4607
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4725
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4726..4854
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4855..4982
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5065
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5066..5101
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5102..5165
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5300
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..7493
                     /gene="Arap2"
                     /gene_synonym="Centd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctgcgc gctagcccgc cgagcccagc cgcgctcccg cctccaggtg cggcgtgggg
       61 tctacctgct cgccccctcg tcctccagct ggggacagcg cacctcgggg acgagccggc
      121 gctgagctgc ccaggttccg cggccgcgtg cgagcgaggc gagtccccgg ggtgtgttgg
      181 ccgcggtacg gtcccgggtg cgagaacgtc gcacttcggg gtgggctggg tactccggct
      241 gctctagatt gtgccgctcg ggttgcgctt ccctcgagtg ggcgtcggaa gagaaaccaa
      301 aggcgccatt cggcctccac ctgcttgaac ccagcactgt accaggggac ctcttggagt
      361 gcggttacca ggcagctctt tcacctttag tgtgggaagc agttctcatg ggagaatcgg
      421 tgtccatcta ttaattgaag tttgagcaca tgaacagaaa ataacgttct aagaactttt
      481 gtcagaagtg atagaggaaa aaaacaaccc ataatataca tccttgtgtg tgtctcattg
      541 agcagtttta aaaatactca gatagtaatg aagccaccat tatgtccgca gtcagtgaag
      601 taaatgtgga catccaagat ttcctgatga gcatcaattt ggagcagtac cttttacatt
      661 tccaggaatt tggtttttat actgtgaagg actgcacatc aataaatgac aacgtgctac
      721 atcaaattgg aatatcacct acaggacacc gtaggaggat acttaaacag ttgcaaatga
      781 tcttttcaaa gatgcaagac tttccaatat atgcaaatgt ttataagaca aagaacggca
      841 gcaccccaaa agagcaacac agtgctccgt cttccagcag caacacctgc atagagtttt
      901 ctgattctgt tactgtccat agacctggcc cagcaccatc agagatggtt acaaccaatg
      961 tccttagtga aggaaactgt cattcttcta catcacatga taagctatct ctttcttcga
     1021 gtgaccttcc ctgtccagaa gaagagatat gccagaatgt ggattcttcg caagattatt
     1081 tatttggtcg tgtaaatgtt aaaatagatt ccttgattac ccagcaggct gtggagcata
     1141 cagctggaga agaacaaaca gaaaaagtca atttggtgtc agaagattct agcaaggcac
     1201 ttaacacaaa cactgaatgt cttccttctg tggaccatcc agcatcggag acacactgtg
     1261 gaaatggaac taacggtgta ttagaaagct tcccgccatc ccccttcttc cagtttcaag
     1321 gagagatggt tgtgaatgaa ctgtatgttc catcctcacc aatccacagc cccatgagaa
     1381 gccggagcaa gttggtgtcc agaccttctc gatcatttct gctgagacat cgccctgtac
     1441 cagagatccc agggtcaaca aaatcaattt cagggagcta tttccgtgac agaaagagta
     1501 ttactacctc agctggaaaa tctttgacac tgaaagatgc aaatgaggat aattcaactt
     1561 ccatctttcc ttatggagag acatttctct tccagagact agaaagttcc aagaagcgat
     1621 ctataaagaa tgaattttgg gcccatgagg acacagttaa agaggaagca gccacttcaa
     1681 gaaactctat cctaaccaag tcaagcatat atgatagcag gaaggaaaaa gtgagtgaag
     1741 acaaagtaga agacatttgg ataccccgtg aagataaaaa taatcttcca caggattctg
     1801 cttctgagtc agaatactca acagttgagg agtgcttcca gagtttaaga agaaaaaatt
     1861 ccaaagcatc taagtctagg actcaaaaag ccttctactt ggaccctttt aataggcaca
     1921 gttatcctct aagttccaca agtgaaaata ctgatccatc aaccatcgca aatgccatct
     1981 ctccctatgc ctgcttctat ggctcttctg cagctaaagt gaaatctgga tggctggaca
     2041 aactctctcc tcaaggaaaa cgcatgtttc agaagagatg ggtgaaattt gatggcctta
     2101 gcatttctta ctacaataat gacagagaga tgtactcaaa gggaataatc cccctcactg
     2161 ccatatccac agtacgggcc caaggagaca acaaatttga aattgttaca acacaaagga
     2221 cttttgtttt tagagtagaa aaagaagaag agaggaatga ttggatcagt gtattattaa
     2281 gtgcactgaa gtcgccatcg cttacatcac agttgcaagc agccgtggca cctgagaagt
     2341 gtggatatct tgaattgaga ggctataaag ccaaaatttt tactgtgtta aggggcaaca
     2401 gtgtgtggct ttgcaaaacc gagcaggatt ttaagagtgg acttggcatt accataattc
     2461 ctatgaatgt tgcaaatgtg aagcaaatag atcgagctgt gaaacagtct tttgagataa
     2521 tcactcccta caggagtttc agcttcacag ccgattcaga gaaagaaaaa caggaatgga
     2581 ttgaagctgt gcagcagtca atagcagaaa ctctctctga ttatgaagta gctgaaaaga
     2641 tttggtttaa tgaatccaac aggagctgtg cagattgtaa ggccccggac cctgactggg
     2701 catccatcaa tctctgtgtc gtcatctgta agaagtgcgc aggacaacat agatctttgg
     2761 gaccaaagga ctcgaaagtt agaagtctga aaatggatgc cagtatttgg agcaatgaac
     2821 tcatcgagct atttattgtc attggaaaca agagagcaaa tgacttttgg gctggtaacc
     2881 ttaaaaaaga tgaagaaata cagatggatt caccagtgga taagagaaaa atctttatta
     2941 cccagaaata caaagaggga aaattcagaa agactttttt agcatctcta accaaagaag
     3001 agttaaataa ggctctgtgt gctgcagtag tgaagccaga tgtgctggaa actatggctc
     3061 tgctcttcag tggagccgat gtcatgtgtg ccacaggaga ccctgtgcac tgtaccccct
     3121 acctgctggc caagaaggct gggcagagtc tgcagatgga atttctgtac cataacaagt
     3181 tctcagattt ccctcagtac gatgctcatt ctgagggtgg gtcaagtcag gaggctacac
     3241 agtccacgtt cctctgtgac ttcttatatc aggccaccgc ctctgcctct agagtctcca
     3301 cagagaagaa gctacttgaa gagacaaata aaaaatggtg tgtattggaa ggcggcttct
     3361 tgagttacta tgaaaatgac aggtgtacca cacctaatgg taccattaac atcagtgaag
     3421 ttatctgcct gactgtccat aaagaggact tctatttgaa tactgggccc atcttcatct
     3481 ttgaaatcta cttaccttca gaacgtgtct ttttgtttgg agctaaaaca tctcagattc
     3541 aaagaaaatg gacagagaca atagccaagc gttttgttcc ctttgttgct gaaaacttaa
     3601 cagaagctga ctatgatctg attggtcaac tcttctacaa agactgccat gctctggacc
     3661 agtggagaaa aggctggttt gctatggaca agtctagctt gtgtttttgc cttcaaacgc
     3721 aagaagctca ggaagagagg atgcacctaa gaagactaca ggaactaaca atcagcacag
     3781 tggttcaaaa tggagaaaaa gtagatgtgt tactcttggt agaaaaaggg agaacactat
     3841 acatccacgg gtacaccaag ttggatttca cagtctggcg taatgcaatt gaaaaagcag
     3901 caggtacaga tggtaacaca ttacaagatc agcagctctg caagaatgac gtccccatta
     3961 ttgtgaacag ctgcatagca tttgttacac agtatggatt gggatgcaaa tacatttatc
     4021 aaaaggatgg tgatcctttg tctataagtg aactcctgga gagtttcaag aaagatgcaa
     4081 ggagtgttaa gttgcgagtt ggaaaacatc aacttgaaga tgtgacaggc gtgctgaaga
     4141 gttttctgtc tgacattgat gatgctctcc tcaccaagga gctctatccc tactgggtct
     4201 ccgcattaga tgcacaagat gaaaagcaaa gaactgacaa gtacagagcc tttatatgct
     4261 ctcttcctgg ggtcaacaga gcaacactgg cagctctaat tgaacacctt tacagggttc
     4321 agaaatgctc agaaatcaat cacatgaatg cccataactt ggcactggtc ttttcatcct
     4381 gcttatttca aactaaggga caaactagtg aagaagtgaa tgtaattgaa gatctaatta
     4441 ataattatgt ggaaatattt gaggttaaag aagaccaagt caaacaaatg gacatagaaa
     4501 atagctttat aaccaagtgg aaaaacactc aagtgtccca ggctggagac ttgttaatcg
     4561 aagtgtttgc agaaagaaag gaacctgact gtagtattat aatccgggta tctcctgtga
     4621 tggaagcgga agagttaacg aatgatatat tagcaataaa aaatattctt cctacgaaag
     4681 gtgatatttg ggccacattt gaagtcattg aaaatgaaga gctagagcgt ccacttcact
     4741 atacagagaa tgtgttggag caggtgcttc agtggagttc attagctgaa cccggttctg
     4801 cttatcttgt ggtgaagagg ttcttaacca ttgacacaat taagcagtgc agagagaaaa
     4861 gtatcaagga aggcatctta aaactcaaag aagaaccatc taaaatactg tctgggaata
     4921 agtttcaaga ccgatgtgtt gttttacgag atggacatct ctttatttac aaggatccaa
     4981 agagcaccaa acatgaaaag atgtttcctc ttaggttgat gaagttttat cttggtgtca
     5041 agaagaaaat gaagccccca accagttggg gattgacagc ctgttctgaa aaacaccact
     5101 ggcacctatg ttgtgacagt ttacaagccc agatggagtg gatggccagt atctttattg
     5161 ctcagcatga aaatgatata tggccaccag ctggaaagga acgaaaacgt tcaataacca
     5221 aaaatcccaa gattggaggt ttacctctga ttcctattca acatgagaaa aatgcaactc
     5281 aggcccgtaa gaatattgag atggcaagag cagaacttga aagactgcgg ctgagtgaaa
     5341 ggcatgacgg agactttaca gactccagct taaaagacag agcttccatc ataggctact
     5401 gcttggagca caaagatgag aaacttcgaa atcgtgccag aaaacatcgc agtttcaact
     5461 gtctggagga cacagaggca gaggtcccgc ctggcctccc aaagggttat aaaggtctaa
     5521 agacagtgaa gaagacagag gacagaaaca gcaaagccac attagaaccc aataataagc
     5581 tgccatcgaa ggtcattgag gaacttagtg tggttctcca gaggtcaaga tcccatccta
     5641 aagagttacc agatgagcaa acgttataga aagagataaa atagatcatc gcacaagtta
     5701 ttttttttaa cattgtatac actgtgtgca aaacaaatca aactgtaatt cttgagtttc
     5761 tatatctagt atgaatttgt ctgtatttaa ggaatttgtt tatctatact gaagcactga
     5821 aagagcattt taaaatatgt atatatgtgg ttacctgtaa gatcaactat attttggtct
     5881 ggaaacttga aaagttcaac cgtattaact ttataaagtc tttgagtcac tctaagtgac
     5941 cagctctttg aaagtagatg tgttaagtgg gttaatttat gatcagaaat ctgtatttta
     6001 ttgtataaaa tgctgtgttt atgaatccta tgaatttgta tcataattta cactttgaga
     6061 ggcttgtaag ttaagttgtc atgtggtttt aggttaatat agggtccatc ttagggaaag
     6121 aaaagggaag gtagttccaa aagggaaaga tactgcaatg gctgcttaac aaacattggg
     6181 aagaaaggca agagagtaaa aaacattcca ctacccatgg aggtatccta aatcactgag
     6241 gaacaaacct tgttaaggag aacctccttg ttaagaaaag aatcctcagt gtcttgagtg
     6301 tttccaacaa aaatattgag ctggcctatg ttggtaatgg cagtgactgc tgtcatttat
     6361 ggtgtcagta gacaggcccc atgacacact acaccagagc aactgtcttt gagtgcctgc
     6421 tcagaggaac ttaccttgca ctgaagagtg tgcatgggcc cagcacaggt gttgctgtat
     6481 gcagacagtt ctttagggtt ccaaactgta tttttggtac gaatgaaatt catcaccatg
     6541 gggtcgtttg gctttttttt tttctttgtt gcattttttt ttgtttcatt tcttaatgta
     6601 acataaaatg ttttcttctg tgttatcagt gtctactgaa agtgggcaat ctggctactt
     6661 aagcaacaca tttgcaggca ggcaggtcac gttccaattt agccttttct ctctacctgt
     6721 ggaaatgaaa tagccctgtg ttttggttgc cacttaataa tcgggtatag atttgataat
     6781 gttccttctg actacattag cttttaacag tttatgtcaa agacagcact tttcataaat
     6841 tctttccaag tcaagtcaag ttggtttggc gactcttaga actggaaggt tttttgttgt
     6901 tgttgttgtt gttgttttgt cctcttctgt attttctctc ctatttatga catgtctggt
     6961 ctatgagctc aagcctttgt tttacgtact cacaggaaag cagcatgcta tgaattacta
     7021 ggtccatctc actcagatat gctaaccaca tgtatttgtt gaagatagca gagttaacta
     7081 ggcgtcagtg gaatctattc cttacatcca aataaactgt aaaggaaata aaaagtgaaa
     7141 ctacagggca gttgccacta cggaggatcc ttcttcaaag acagatcttg tgttgtttgg
     7201 gaagcaaagc ttaattttta gtaaatttgt ttctaatatg taatcatatt tatattttta
     7261 ttcaataaag agatatatgg aaataatgtt actggccttg ttgggtaagt tttaggtgct
     7321 ttggccttac cttattagaa tttctcctga gagttgacct taaaatctat cacatctgtt
     7381 tctcttcttt tcgtgagcaa ttgtctccac ttttcaaatg taacataagg gctaatgatc
     7441 acatcatatg tattttgagt aacaattaaa atagttttac aagtccagta aaa
//
LOCUS       NM_001437144            7417 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 40
            (Zbtb40), transcript variant 1, mRNA.
ACCESSION   NM_001437144 XM_006239232
VERSION     NM_001437144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7417)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   2  (bases 1 to 7417)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 7417)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006239232.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.23932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000005.1  154567023-154567177 c
            156-263             JAXUCZ010000005.1  154555959-154556066 c
            264-1012            JAXUCZ010000005.1  154537110-154537858 c
            1013-1146           JAXUCZ010000005.1  154536331-154536464 c
            1147-1303           JAXUCZ010000005.1  154527026-154527182 c
            1304-1446           JAXUCZ010000005.1  154526335-154526477 c
            1447-1639           JAXUCZ010000005.1  154520544-154520736 c
            1640-1720           JAXUCZ010000005.1  154520237-154520317 c
            1721-1857           JAXUCZ010000005.1  154518824-154518960 c
            1858-2059           JAXUCZ010000005.1  154517866-154518067 c
            2060-2193           JAXUCZ010000005.1  154517219-154517352 c
            2194-2362           JAXUCZ010000005.1  154515400-154515568 c
            2363-2821           JAXUCZ010000005.1  154514633-154515091 c
            2822-3028           JAXUCZ010000005.1  154513780-154513986 c
            3029-3193           JAXUCZ010000005.1  154510949-154511113 c
            3194-3408           JAXUCZ010000005.1  154509221-154509435 c
            3409-3571           JAXUCZ010000005.1  154508168-154508330 c
            3572-3658           JAXUCZ010000005.1  154507481-154507567 c
            3659-3885           JAXUCZ010000005.1  154505013-154505239 c
            3886-7417           JAXUCZ010000005.1  154499950-154503481 c
FEATURES             Location/Qualifiers
     source          1..7417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7417
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="zinc finger and BTB domain containing 40"
                     /db_xref="GeneID:362635"
                     /db_xref="RGD:1309866"
     exon            1..155
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            156..263
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1012
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="upstream in-frame stop codon"
     CDS             316..4080
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 40"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 40
                     isoform 1"
                     /protein_id="NP_001424073.1"
                     /db_xref="GeneID:362635"
                     /db_xref="RGD:1309866"
                     /translation="MELPNYSQQLLLQLYALCKEQRFCDCTISIGNIYFRAHKPVLAA
                     ASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFSKIISLADSLQM
                     FDVAVCCKNLLTNLVNCSVQGQVVRDISVLSSEAGGKESEKPQVEVLSSEGAGEPSSS
                     LEVSAMPAGTEKAKTQEVIHMVTQEISADPPIAQEVQVAAEITGATPHTTEVCSPLPA
                     GQIPSEAKAASTEAGCERKQDQLTLLLEYESVFSSAALLTPDMLRRLEGCSEIEGPQK
                     ETVMECLEAEGGGSAFQRILDKVHDGSLDVQVALSLMRLCQESTPAEKVSQIEGSAGE
                     GKTLSVLLLEHKEDLIQCVTQLRPIVEFLETAKEEFLPDSEKRVIQICCEGRTPKETV
                     ENLLHRVTEEKTLPAKSLVKLLQAVRTAFPNLGLLLENLQKVAESPGTTGLTRATRET
                     AWTEEPKRLCIPADRVDGSSPNPDAYGAELLRKYHENLSEILIDSQVLLKVISRLKSL
                     APGDREVMQTLVKQDSGSGGVSSLMSAALERQTVSAAAIWQLLLAAQETETCPLNLLL
                     EEVEREPGAGAFFRAVTAPESTVLETILRHSKLVREAIQQTVGREHLSSEEEHLAETV
                     KEMLSISSETVSPEASLRVVLSRAMEKSVSASVVCHLLCSVHRSFPGLQPLMQELAHV
                     GFLTKENAEERWKVTDGLHPGAKDKTEEAAEAAREDGRAMEQKEQGPEPVPERQEKDT
                     SASPDAAKKSFVCKACDKSFHFYCRLKVHMKRCRVAKSKQAQGKGDSDTRDSEKELGR
                     QQPEARSAGAEPDAPKKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDEKPFSCEEC
                     GAKFAANSTLKNHLRLHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCD
                     AVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRM
                     SFSTLQDHRKHIHDVHSKEYHPCPTCGKIFSAPSMLERHMVTHVGGKPFSCGICNKAY
                     QQLSGLWYHNRTHHPDVFAAQNHRSPKFSSLQCSSCDKTFSNTIEHKKHIKTEHADLK
                     FHECGQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQS
                     ESTFPCELCGELFTSQAQLDGHLESEHPKVTGTETQAAASRMVQVIQAPEPAAPAEQV
                     ITLEETQLAGSQVFVTLPDPQTSQNSSELVAVTVEDLLDGTVTLICGEAK"
     misc_feature    316..663
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 40 (ZBTB40); Region:
                     BTB_POZ_ZBTB40; cd18225"
                     /db_xref="CDD:349534"
     misc_feature    316..663
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 40 (ZBTB40); Region:
                     BTB_POZ_ZBTB40; cd18225"
                     /db_xref="CDD:349534"
     misc_feature    2785..2850
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2785..2850
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2785..2787,2794..2796,2833..2835,2848..2850)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2785..2787,2794..2796,2833..2835,2848..2850)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2872..2934
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2872..2934
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2872..2874,2881..2883,2920..2922,2932..2934)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2872..2874,2881..2883,2920..2922,2932..2934)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2887..2889,2893..2895,2899..2901,2905..2910,
                     2917..2922,2929..2931,2971..2973,2977..2979,2989..2991,
                     3079..3081,3088..3093,3100..3102,3142..3144,3148..3150,
                     3154..3156,3160..3165,3172..3177,3184..3186)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2887..2889,2893..2895,2899..2901,2905..2910,
                     2917..2922,2929..2931,2971..2973,2977..2979,2989..2991,
                     3079..3081,3088..3093,3100..3102,3142..3144,3148..3150,
                     3154..3156,3160..3165,3172..3177,3184..3186)
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    <2920..3678
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <2920..3678
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    2956..3105
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2956..3105
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3127..3186
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3127..3186
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3214..3270
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    3214..3270
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    3382..3444
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3382..3444
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3502..3561
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3502..3561
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3589..3654
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3589..3654
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3676..3735
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3676..3735
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3769..3822
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3769..3822
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1013..1146
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1303
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1446
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1639
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1720
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1857
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2059
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2193
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2362
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2821
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..3028
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3193
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3408
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3571
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3658
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3885
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..7417
                     /gene="Zbtb40"
                     /gene_synonym="RGD1309866"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggccctgg gcgtccccgg ccccaagatg gctgcctttt ggcgtctcca gcgctgttga
       61 atggagaaag ctttattgtt cccttcgggc aggagtgttc gtgttctcta tggcgctgtc
      121 aataaagaac ggcagtttga atcggtactg aacagacaga aactcaagta tcctagagtc
      181 acttcaaact gtgtgtccaa ggacaacttt aaacttcgga tcctcctccc tctacgtctt
      241 gagttccggg tttacgatta ttggacttgg tggagtctga aggtctagag gaagggttcg
      301 agggtggccc acaccatgga actccctaac tacagccagc agctgcttct gcagctctac
      361 gccctgtgca aggagcagcg gttctgtgat tgcaccattt ccatcggcaa catctacttc
      421 agggcccaca agccagtcct ggcagcagcc agcctcctgt tcaaaaccct gctggatagc
      481 acagatgcca tctccattga tgcatcagtg gtgagccctg aagagtttgc cctcttgtta
      541 gaaatgacat ataccggcaa gctacctgtg ggcaagcaca acttctccaa gatcatctcc
      601 ttagcagata gcctgcagat gtttgacgtg gctgtttgtt gtaaaaatct tctgaccaac
      661 ctcgtaaact gctctgtcca ggggcaggtg gtaagggata tctcagtgct gtcctcagag
      721 gcaggtggca aggaatcaga gaagcctcaa gtagaagtcc tttcctctga aggtgctggg
      781 gagccctctt cttccctgga agtttctgcc atgccagcag gcactgagaa agccaagacc
      841 caggaagtaa ttcacatggt tactcaagag ataagtgcag accctcccat tgcccaggag
      901 gttcaggtgg ctgcagagat cacaggggca actcctcaca caaccgaagt ttgttcccct
      961 ctccctgctg gacagatccc aagtgaggca aaggcagcca gtacagaagc agggtgtgag
     1021 aggaagcagg accaactgac tctcctgcta gaatatgaaa gtgtcttctc aagtgcagcc
     1081 ttgctcaccc cggacatgct gaggagactg gaaggatgct ctgagattga agggcctcag
     1141 aaggagaccg taatggaatg tctcgaggcc gaaggaggag gctcagcatt ccagagaatc
     1201 ctggacaaag tgcatgatgg gagcctggat gtgcaggtgg ccctgtctct gatgagacta
     1261 tgccaggagt ccacacctgc agagaaagtg tctcagattg aagggagcgc aggagaggga
     1321 aagaccttgt ctgttctgtt actagaacac aaagaggacc tgatccagtg tgtaacacag
     1381 ctcagaccta ttgtggagtt cctggaaaca gccaaggagg aattcctgcc agactcggaa
     1441 aaaagggtga ttcagatctg ctgtgagggc agaacaccca aggagacggt agagaatttg
     1501 ttgcacagag tgacggaaga gaagaccctg cctgccaaga gtctggtaaa actccttcag
     1561 gctgtgagga cagcattccc aaacctgggc ctcctgctgg agaatttgca gaaagtagcg
     1621 gaatcacctg gcaccacagg cctgaccaga gctacccgtg aaactgcatg gacagaggag
     1681 cccaagagat tgtgcattcc agcggaccgt gtggatggat cctcccccaa ccctgatgcc
     1741 tacggagccg agctgttgag aaagtaccat gaaaacctgt ctgagattct catagacagc
     1801 caggtgctgc taaaggtgat ctcacggctg aagagcttag cccccggaga cagagaggtc
     1861 atgcagaccc tcgtgaaaca ggactctggc tcgggtggcg tcagttccct gatgtcagca
     1921 gctctggaaa ggcagactgt ctctgcagcg gccatttggc agctgctgct agcggctcaa
     1981 gagaccgaga cctgcccgct gaacctgctg ttagaggaag tagagaggga gcctggcgct
     2041 ggggcttttt tccgggcagt aactgcccca gagagcacgg tgttggaaac catcctgagg
     2101 catagcaagc tggtccgcga ggccatccag cagacagtgg ggcgtgaaca cctttcttca
     2161 gaggaagagc acctggcaga gactgtgaaa gagatgctga gcatatcctc cgagacggtg
     2221 agccctgaag cctccctgag agtggtgctg agcagagcca tggagaaatc cgtctcagcc
     2281 tctgtggtct gtcacctcct atgcagtgtc cacaggtctt tccctggcct gcagcccctc
     2341 atgcaggagt tggcacatgt tggtttcctt accaaggaga atgcagagga gaggtggaag
     2401 gtgaccgacg ggcttcaccc tggagccaag gacaaaacgg aggaggcagc tgaggcagcc
     2461 agagaagacg gccgggccat ggaacaaaag gagcagggac ctgagcctgt gccagagcgg
     2521 caggaaaaag acacttctgc ctccccagac gctgccaaga agagcttcgt ctgcaaagcc
     2581 tgtgacaaga gcttccattt ctactgccgt ctgaaggtgc acatgaagcg ctgccgggtg
     2641 gccaagagca agcaggcaca gggcaagggt gacagtgaca ccagggactc ggagaaggag
     2701 ctggggaggc agcagccgga ggcccgcagc gcgggtgcag agcccgatgc tcccaagaag
     2761 aagaagaagc gactgccagt gacatgcgac ctctgcggaa gagagttcgc ccacgcctca
     2821 ggcatgcagt accacaagct gacggagcac ttcgacgaga aacctttctc ctgtgaggaa
     2881 tgtggggcaa agtttgcagc caactctacc ctaaagaacc acctgcgcct ccacaccggg
     2941 gaccgcccgt tcatgtgcaa gcactgcctc atgaccttca cacaggcctc ggccctggct
     3001 taccacacca agaagaagca ctcggaaggg aaaatgtacg catgccagta ctgtgatgct
     3061 gtgttcgccc agtcgatcga gctgtctcgg catgtgagga cccacacggg ggacaagccg
     3121 tatgtctgta gggactgtgg aaagggcttc cggcaagcca acggcctctc catccacctg
     3181 cacaccttcc acaacataga agatccttat gattgcaaga aatgcaggat gagcttctcc
     3241 acactgcagg atcaccggaa gcacatccac gacgtgcact ccaaggagta ccacccctgc
     3301 cccacatgtg ggaagatctt cagtgctcct tccatgctgg agcggcacat ggtgacccac
     3361 gttggaggga agccctttag ctgtgggatc tgcaacaagg cctatcagca attgtcaggt
     3421 ctatggtacc acaaccggac acaccaccca gatgtgttcg ctgctcagaa ccatcggtca
     3481 cccaagttct catcactgca gtgcagctcc tgtgacaaga ccttttccaa caccatcgag
     3541 cacaagaagc acatcaaaac agagcacgca gatctgaagt tccatgagtg tggccagtgt
     3601 aaggagctct tccccacacc agctctgctg caggttcacg tcaaatgtca gcattcaggg
     3661 tcacagccat tccggtgctt gtactgtgca gccactttcc gcttccctgg agcactgcag
     3721 caccacgtca ccacagagca cttcaagcag tcagaaagca ccttcccctg tgagctctgt
     3781 ggcgagctct tcacctccca ggcccagctt gatggccact tggagtctga gcacccaaag
     3841 gtgacaggca ctgagaccca ggcagctgcc tctcgcatgg tgcaggtgat ccaagctcca
     3901 gagccagcag ccccggccga gcaggtgatc acgttggagg agacgcagct tgctggctca
     3961 caggtgtttg tgaccttgcc agacccacag acctcccaga acagctctga gcttgtggca
     4021 gtgacggtgg aggatttgct ggatggtact gtcactttga tctgtggtga agccaagtga
     4081 gtggctgctc cttcagtaga ggagcctgtg ttggaccagc acggatgccc acggcctacc
     4141 tctgctgctt agctaagctc caccctggtg ctctcacggg gaagacagag gctttgtcat
     4201 tttcctggga tccagtgtct gagctaacca cactggtgcc agcactactg cccttcgtgg
     4261 cagagagcct cagtcctcca ggcctgcatt cccccacccc agggaagtct ggcttctgga
     4321 gtcagagtct gagggaatcc agggtgacca aggagataca gcatgctggc cgccctcagg
     4381 agcagggcag ttacctgagt ctgagccaac agggggccac agacaccacc agtgcctctg
     4441 ccagtaaagc acccacacag cctccaggga ccccagcgtg gcagctgtcc tccctccacc
     4501 cctgccccag ctcgggttcc ctttggaggc tgtaaaacac gcgttaacag tgcaggtctc
     4561 cattggcttc cccaatcctc cctgctctgt ctttctcaaa acaaagcttt gagcattgcc
     4621 actggggggc cgcttcctgt gaggtcaccc agctgcctct gccttcctgg gtgttcatca
     4681 gagcctccct gtgagcttca ggccttccac atctgctaat caaggctgaa ctgcctcagc
     4741 ccggagacct cttgctgact tcctctgtac cgtgtgatag cctaatgaac cagcttgtgg
     4801 gggcaggcct gtgcctgcat gtgatggatt agcagcatct gaggtggcct ctgcttctcc
     4861 tgtcactggc ctgcatgtct ggtgcatggc ctgctctctg ggatccccag gctgcatact
     4921 tactgcagca ccatgcttct ttcaagtctg agtgtcgcag agcctctcat ccttagttcc
     4981 tgacgtgcgg tctgtaattg atggcttgtg gaatccggtt ggaagggcaa ttagatggat
     5041 gttggttcct gctgcttaga gagaagggct tgcatttatc ttacctttct agaagcctga
     5101 agagaggagt gggttatcac agtatttgcc catctggccc ggctccctgt cacctgtgtg
     5161 gctgactccc tacagtggga acaccctgat ttggtactca cctttagcca cctgctataa
     5221 gataagccca cagcttcctg ccaggtgcag ctcacatgag cttgtgcaga gatgtgggtc
     5281 cagtgtggcc atggtgaagg tgcattgccc ccatccctca gctgcctcac aggaggacac
     5341 aaagtagcag cgtaacccac agcagtgtct aagggctgct gccctttggc ctcagcttgg
     5401 cacaggcagt actggtgagt gtctaagctg gacaccagct ctggccagcc tctcctgtca
     5461 accctgccct cctcattcca gatgcaaatc gtttgaactt accagctagg gaatcctccc
     5521 tttctaaaag tcaatgtttt tcaaacgtgt cagcctcaga aaccaaacac tgaccagaag
     5581 atggtgctca agcatcaaaa cttcacctcc ctggtttctc cactgcagtc ctagcctgct
     5641 ggctttcaga cctgtgccag ccgaccaggg gagctcttga tctctaagtg gtgtaacagt
     5701 tcctcagtcc atctgcgtca agtaacccac taaaagacag cggaggggca catgtgtcca
     5761 ggccctgtca ggaacagcac gtcacaggct gtggaggact taggaactgt gtagtgagtg
     5821 tcaccaaaaa gtctcttcct ggtgacaggc aaaccttgca gaggtcctgt gtgagaaagt
     5881 ccatttttaa atataaagag ctgtaagtta gaagcctgaa tgtcaggccc tttccagcct
     5941 gagaaacagt ctccgttttc ctgggacctg ggtggtgtgc acgtatgtgc agtcagcaga
     6001 catggttcac tacagagagc cttgggcagg taggcttgct gcccttcctt ggatgcccag
     6061 ctctggaata cacacggctg gaggcacagc agtgctgggt gtggagtatg gagaactcct
     6121 gtcttccacg agttctgtgc tggtgacgtg tgacctctgc cccagctgct gactttttac
     6181 agtggctctg aagaaggtga aagtctccac ctactgcccc agagaacagc cacatgggcc
     6241 tccttagtcc acattgcttt tgcaatggaa atgtggttcc atttgcctca tcttcttgaa
     6301 tactgcctgc ctagcccttg ggcagcagct ccagcagtct gtgggtccct tggaacttgt
     6361 gtatttgagc agtgggaccc caactcagcc accaaagagg ggaaggcaga tgccaagctg
     6421 gagtccagtt ggcccatcac tggtgtaagg acagcaaact ggtgactgaa gagcagccta
     6481 ctgtcagcag gagagagctg ctgtcctact gtcagcagga gagacctgct gtcaatgcac
     6541 gagcagaacc taggccagcg cggcagataa aggtctttct cgggtgtttt acaagactgg
     6601 actcttctgt cttctaagct gtacgtcgga aaagctttga gctcagtccg tacccaagcc
     6661 tgtgatgtga gttctgggcc tgtgtgttgt actggcccat gctgaccaca ggagaggcct
     6721 cagccttgtc cctgagcact gatggttagg gctgggatga ggggcagaca gatgccaaat
     6781 gaggggaaag agctctgtgt cctggggaca ggagggtggg cctttacatt tcttgtgcct
     6841 gggaacctga gctgacagga cggagcacta aggcccactt agcgtgcgct cgttgggaac
     6901 agcagtgcct ttcggagctg gaaagtcggc cagtggtgga gatgacactg gtttgctcca
     6961 gtcagcctct cccatcccag ctttgttctg ggtcctgtgt gtcccagcag atgacactca
     7021 gaagggattg ggagtaaatg acttagggct gagggggtca aaggcaggtt cacagttttg
     7081 ttgctgtgga aaccttgggg gcactgagaa ctacgctaaa aactacggac ctcaaactta
     7141 ctcagtctaa ctgggcctct agagaagagg ggagtggtga gttctttgcg gaccgatggt
     7201 gttgttgagg aaatcattcc atgagcaagt ttacatcgtc tccaaacggt gaggctggcc
     7261 gtggtttccc tgagcaaggc tgctggtgct tgtttccacc atggccaaga cagccagccc
     7321 caggagatgt gtgaactgga ttgcaaacta gaactgctca acatgcactg tggctagaaa
     7381 taaagtctgc tttggaagca gttgtggttt gtgtact
//
LOCUS       NM_001437117            5142 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus RCAN family member 3 (Rcan3), transcript variant
            1, mRNA.
ACCESSION   NM_001437117 XM_006239218
VERSION     NM_001437117.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5142)
  AUTHORS   Guasch,A., Aranguren-Ibanez,A., Perez-Luque,R., Aparicio,D.,
            Martinez-Hoyer,S., Mulero,M.C., Serrano-Candelas,E., Perez-Riba,M.
            and Fita,I.
  TITLE     Calcineurin Undergoes a Conformational Switch Evoked via
            Peptidyl-Prolyl Isomerization
  JOURNAL   PLoS One 10 (8), e0134569 (2015)
   PUBMED   26248042
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5142)
  AUTHORS   Canaider,S., Facchin,F., Griffoni,C., Casadei,R., Vitale,L.,
            Lenzi,L., Frabetti,F., D'Addabbo,P., Carinci,P., Zannotti,M. and
            Strippoli,P.
  TITLE     Proteins encoded by human Down syndrome critical region gene 1-like
            2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with
            cardiac troponin I (TNNI3)
  JOURNAL   Gene 372, 128-136 (2006)
   PUBMED   16516408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006239218.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.226081.1,
                                           SRR26360172.1428134.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000005.1  152955258-152955485 c
            229-464             JAXUCZ010000005.1  152946794-152947029 c
            465-638             JAXUCZ010000005.1  152942483-152942656 c
            639-810             JAXUCZ010000005.1  152940256-152940427 c
            811-5142            JAXUCZ010000005.1  152934561-152938892 c
FEATURES             Location/Qualifiers
     source          1..5142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5142
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="RCAN family member 3"
                     /db_xref="GeneID:362627"
                     /db_xref="RGD:1311826"
     exon            1..228
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    108..110
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="upstream in-frame stop codon"
     exon            229..464
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..989
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="regulator of calcineurin 3; Down syndrome critical
                     region gene 1-like 2"
                     /codon_start=1
                     /product="calcipressin-3"
                     /protein_id="NP_001424046.1"
                     /db_xref="GeneID:362627"
                     /db_xref="RGD:1311826"
                     /translation="MLRDSLKSWNDSQSDLCSSDQEEEEEMVFGENEDDLEEMMDLSD
                     LPTSLFACSVHEAVFEVQEQKERFEALFTLYDDQVTFQLFKSFRRVRINFSKPEAAAR
                     ARIELHESEFHGRKLKLYFAQVQVSGEARDKSYLLPPQPTKQFLISPPASPPVGWKQS
                     EDATPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEDTKNPKQKI
                     TQTRRPEAPTAALSERLDCAL"
     misc_feature    441..944
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="Region: Calcipressin; pfam04847"
                     /db_xref="CDD:282674"
     misc_feature    441..944
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /note="Region: Calcipressin; pfam04847"
                     /db_xref="CDD:282674"
     exon            465..638
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..810
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..5142
                     /gene="Rcan3"
                     /gene_synonym="Dscr1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgcacc cgttgggcgc gaggaaccca gggagggcgc gaggcgcgcg ggtccgggaa
       61 cgcgcgcgac gccggcgacc tcactcggcc ccaggtcacc gcccgtgtag ccggctgagg
      121 tggccgctgg ggcccgcgtc gagggcgtgg tggctcccgg cggtgaaagt ctgtccgccc
      181 ctggccgtgc tcgtttcccc cccggggcct ctcccctgga gcgcacagca ctgtctggcc
      241 agcgtcctag aactttaccg acagagaaga tgcttcgaga cagcctgaaa tcttggaatg
      301 acagccagtc agacctctgt agcagcgacc aggaagagga agaggagatg gtcttcggtg
      361 aaaatgaaga cgatttggaa gagatgatgg acctcagcga cctgcccacc tccctctttg
      421 cttgcagtgt ccacgaagcg gtgtttgagg tccaagagca gaaggagagg ttcgaagccc
      481 tgttcaccct ctatgatgac caggtcacat tccagctgtt caagagcttt cgcagagtga
      541 ggatcaactt cagcaagcct gaggctgcgg cgagagcacg gatcgagctc catgagagtg
      601 aattccatgg ccggaagctg aagctttact tcgcacaggt gcaggtgtcc ggggaggctc
      661 gggacaagtc ctacttactg ccaccacagc ccaccaagca gttcctcatc tcccctcccg
      721 cctcaccccc cgtggggtgg aagcagagtg aagatgccac gccagtgatc aactatgacc
      781 tcctctgtgc cgtctccaag ctggggccag gggagaaata cgaactgcac gcaggaaccg
      841 agtccacccc cagtgtggtg gtgcacgtct gtgagagcga aaccgaagag gaagaagaca
      901 caaaaaatcc aaaacagaaa atcacgcaga cgcggcgccc ggaagctccc acggcagcac
      961 tgagtgagcg gctggactgt gcactgtgag cggctgctgc gcctgcgcct tccactgcta
     1021 cagccgcgcc tgccttggag cgcagcccag cgatgctgat gcatccgtcc agctgctggg
     1081 ccagcctccc cgggccggaa cgtggaatga agtggcagat tcagccagcc ggttcagatt
     1141 tcgaacagta ttctaaatgg cactttaagt gacaaggtta gccctgaccg tgaggcacct
     1201 gtctcctccc ccagaaatat tagttccctt gaacctgtag agcattgggt accggaggcc
     1261 agagccagcg tcacccagtg cactgccatt tctacagact taaacgttag tctcacttcg
     1321 gtgtgggtat ttttgtacag gtgtggcggt gtctaacaga ttgagcaaag gctgaatgta
     1381 attattcagt agacatgacc tttctttttg cacgagaaga aacctgagat acaaaatcat
     1441 ttgtagaagt catttttttt ttcaagtatt ttttcactag ctttagggat gaaaggccaa
     1501 gtgactgaga ttgtcaggtc cagatggcgt gggcagatgc gcccttggct ctcctggctg
     1561 tccatcttac ttggcagtca gtgaaagtgg cgtgcagaac cctgctccca gcgcagccct
     1621 ccccagcctc agctctctgc aggagccttg cctttgccag cagcctgtgt cccgggaagc
     1681 ctggctgatg gctttatgga gctggagccc cgggcagctc ttccgttact ctcttgaccc
     1741 tcctagtgct ggctgctact gcctgaggtt ccctatgctg tgtgcgtcgg cacggatgta
     1801 ggtcgctctt aacttcagac gataatgatg actgtgcaga ccaatttaaa ttgggggagc
     1861 aggttcgttt ttgttttctt tgaagacagg gtttcacttg gtagctcccg ggcctcaaat
     1921 cctctgtgtt cctcctgcct cagcttccca agtgctggac ttacagggga gcaccatgta
     1981 cttgaaagtt ctccgttcaa gtattttagc tgtttggaaa gaaaaatcac ctgcactttt
     2041 cccctgcaga ttagggagag gagtcattct tttgggggtg gttgagcttt tttctttgtt
     2101 tgtttttgtt gttttgagac aaggtttcac actgtagctc aggctagcct gtgactcatt
     2161 atgtagccca agctggcctt gagcccaaga ccattctctt tccttagcct cctgagtgtt
     2221 gggattgcag gcatgggcat gcagttcatg ctttcctttt tagtgaacat ttccaccttc
     2281 acttgcagtt ggtgtccaga tagaattgct tcttactctt tttttgtttt tttgttttgt
     2341 tttgttttgt tttgttttgt tttgttttgt ttttccggag ctggggacca aacccagggc
     2401 cttgcgctcg ctaggcaagc gctctaccgc tgagctaaat ccccagccct gcttcttact
     2461 cttggcgtgt tgttccgtgg gtcactctgc atctctggtg tgctgagctg cagtcccttg
     2521 ctgaaggctg gctctcctgc ctcggggtgc tgtgttacag acgctcgagt ggctccactc
     2581 atccgactgt tctgtcgcac aagcgttcag aactggcagg aagatgtgaa ggggcacaga
     2641 acagaaagta gcatagctgc tactgcaaag gaaggagctt agagaagtga cgccatgaga
     2701 gccgtcatgg gtgacatgtc agggctgagt cccttttgtg gtagaactga tttcatgagc
     2761 gcacacacag aaacacacac acacacacac acacacacac acagagagac acacacacac
     2821 acacacacct gttttctgtc ttattaaaac agggtctcac gtagtccagg ttgatctcaa
     2881 acttgctgtg tcccaaggat gactttgaac tcctggtcct cctgcctctg tctcctaagt
     2941 gctgggactg gaggtgtgtg ccaccatccc tatcaacaac agaagagtgt cccttgcctt
     3001 cagacactgt cagatgctga agtctgcatt tgccattggg aagcctcggt gcagattcag
     3061 ttgaagataa ccattccatc cacacaagtc atctgccagg taaagggatt atatgcatat
     3121 attttgtttt gaggtgatgt ctcacagtgt ggcccaggtt ggtctcaaac tccaggcctg
     3181 tgggtcttcc aacttgactg gatccaggca cacgcccttg tcatcctggg actttagagt
     3241 tggatgcagt agatcaggaa ttcaaggcca tccttggcta cactgtgctt ggccctgcca
     3301 agctcagcag tttgctactt ctggttgtag gatagaccct agctgtcagc aagcatgttt
     3361 tcaactgggg aggttttgtg ttcctcatta tacagtacat gctctgattt tctaagtgat
     3421 cataacccag tttttaaatt tgtcttggct ttcattttct acccaccaat taaagaacat
     3481 ctattgctct tttttaagtc gagacactca aatctgtgtg catcctgtta ccttggtcac
     3541 cagcagttgt gtcagcacct tacgtggggt tccctggata ctcacattca tggaattaaa
     3601 atgtaaacag tggtaacggg gacccaggct caaagaatgc atggagttaa aggtttgctg
     3661 tgggatgtcc ctctccctct gcttagaaaa tcaggttcta ttcaagactc gtggtgggcc
     3721 tgggctatat attttatgta aactattttt agactggagg atttagtttt aagaggaaag
     3781 ctttgagcgc aattaaacca tggaggtgta ccagattctt cgatgccttg gggtcactcc
     3841 tgcttgcttg ccttctataa agcctcagac ctcacctgca aggtgaactt ggtcaccctc
     3901 cacttccctc tgtgttccct aatgcatctg tcttaaaggg aacattgtct gggtgtggtg
     3961 taatctcagc ctgcaggagg ctgaggcagg aggattgcct gggatacatg agtaacccct
     4021 ctctcagaat aaggtatgtt ccttttctcg ctgtgacagt tcagaggaac agtcctggag
     4081 aaatgtttgc ttctagccaa gaatcctgcg ttctagagac tcattctgca caaaactaag
     4141 tacatggacc aagtaagatg tatgaacctt gagcagccac gtgacaagtg actactgctg
     4201 tttcaaactc ccctcgttgt gttctccagg gccatcttcc tcctcaagag tgccactgtc
     4261 tccctcagtc ttgggcagag cacaattcat agtcaggatt accaaatgta ttcagcgcgg
     4321 tggcatatcc cgtcatctca gcgcttggga ggcagaggta tgaggacttt gcaagtttaa
     4381 ggccagcctg ggccatgtac cacgaccctg tctcatcaac gagggggctc ctggatgtcc
     4441 aggtgcccca gacagatagc agtgaccgtg catctctggc tgtggctggg gacttatctt
     4501 cctggtagct tctagtcaag gctagaagtg atctcagata agtcagcatg cagacaccac
     4561 taactggctt catgttctcc tggaaacctg cagttcttga agtgagtcct gagacctggc
     4621 aggtcctgcg tggcctggac tggatgtgcg ttcttgacat gaggagggtt tcttatctat
     4681 ctatgcagat aacgcgtggt tttctgtact gttccttttt gatctccact cttccaaagt
     4741 cagactgagg acaaaggggg gacagcaggt gtcagtcccg cgccgtgccc tctgctgtca
     4801 gcccgagtat ttattatgtc actgtgttac tgcacattga tttcattact gaaccgcagc
     4861 tggatttagt ctcgaatccg gcctgtccgc ggcccccctg gtcctgtgca ctgtagtgaa
     4921 tccttgctgc acttgcagaa actggtcagt gagctttgtc cctgtgtccc gtgatcttag
     4981 tgtgcttgac gtgatgggcc atagttcatt atcagcttca actctcctgt gtcctcagga
     5041 tttctaacat tcctcgtcct gtaaggaggt aacaaaggca gacatgtgat tacctgtaac
     5101 agattttgat gttgaactaa taaaaacttg ttttgtaagt ca
//
LOCUS       NM_001107206            4660 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus ALF transcription elongation factor 1 (Aff1),
            transcript variant 3, mRNA.
ACCESSION   NM_001107206 XM_001065599 XM_223161
VERSION     NM_001107206.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4660)
  AUTHORS   Luo,Z., Lin,C. and Shilatifard,A.
  TITLE     The super elongation complex (SEC) family in transcriptional
            control
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 543-547 (2012)
   PUBMED   22895430
  REMARK    Review article
REFERENCE   2  (bases 1 to 4660)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   3  (bases 1 to 4660)
  AUTHORS   Baskaran,K., Erfurth,F., Taborn,G., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Iannaccone,P.M. and Domer,P.H.
  TITLE     Cloning and developmental expression of the murine homolog of the
            acute leukemia proto-oncogene AF4
  JOURNAL   Oncogene 15 (16), 1967-1978 (1997)
   PUBMED   9365243
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474022.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223161.4, XM_001065599.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMEA5760494
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4660
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="ALF transcription elongation factor 1"
                     /db_xref="GeneID:305152"
                     /db_xref="RGD:1307940"
     exon            1..176
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    16..18
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="upstream in-frame stop codon"
     CDS             133..3645
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myeloid/lymphoid or mixed-lineage leukemia (trithorax
                     homolog, Drosophila); translocated to, 2; AF4/FMR2 family,
                     member 1"
                     /codon_start=1
                     /product="AF4/FMR2 family member 1 isoform 3"
                     /protein_id="NP_001100676.1"
                     /db_xref="GeneID:305152"
                     /db_xref="RGD:1307940"
                     /translation="METKIRPGERGKFACLYNEDRNLLRIREKERRNQEAHQEKEAFP
                     EKAPLFAEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYP
                     SCHDRGSGASGSFRTHVYHQPTHTSAPGSLSVSNVSQSPKMAQPRMEPVPSLHAKIYG
                     APDGPRPAQDRLSQGHCSRKCDRRAEGDSERKLSPFISSLPSPVPPLSPAHSRPQATS
                     KAHGSGTGTQSCYASKPSKDPVVTAQEKETPLDSLVAVTSLGAAPPQPPCQTFPPPPL
                     PSKSIAMQQKPTAYVRPMDGQDQAPSESPELKPPLEDFGQQSFEKPDLKVPAKAKLTR
                     LRMPSQTVEQPYSNEVHCVEEILKEMTHSWPSPLTAIHTPSTAEPSRFPFPTKDPLHI
                     SSATQSQKQYDAPSKTHPNPQQGTSMLEDDLQLSDSEESDVEQAVEKPPSPPAPPSAP
                     QTIPEPVASAHSSSAESESSESDSSSDSESESSSSDSEENEPLETQAPEPEPPTTNKW
                     QLDNWLTKVNQPSVPLESRGSTESPRCRQESKGGGEGSSDQQHPDSKDPPLKSSSKAL
                     RGPSEGPQPGKRNCPKSPAQQETPPPRQTVGSKQPRKPTKGSTQAEQPQASSRVEGEA
                     GPVAYGSKEQTSKDKPKVKTKGRPRAVGSREPKSEVPVPVPQAAVPKPQPPAPTPIEK
                     RKHKSSTAPSKALSGPQPTKDSAGDRNQEHPALVSLTQSQGQPNSGRGSGGGRTSGCR
                     QAVITQEDSCRDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRVPQPPGKGGRP
                     RKSEHKQLPAGKKQDLEARGCDSSSRVTKKRKAEPEKEHSHKRLRLDKSQTSSSSSSH
                     AESSKSKTPRPSSECSRKEMLPPPPVVPSSSSSSSSSQKPSKPAHKRPRPDADIGSQD
                     PPRSSGSTKSSCTDSSVPKHRKVQARDSEHKGSSGDAANPFPVPSLPNGNSKPGKPQV
                     KSDRQQADFHMKEAKKLKCKAEAMVDKAGKAFKYLEAVLSFIECGMATESESSAKSAY
                     TVYSETVDLIKFVMSLKSFSDNTVPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYS
                     RTLSEHFRSTSKVAQAPSPCVARQVHRRSVPRLPNAFSCQLCWIPDECWQQYGGHGGD
                     GHRQHPGHHPEHDLLLCHHHIPCP"
     misc_feature    181..1677
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF-4 proto-oncoprotein N-terminal region; Region:
                     AF-4; pfam05110"
                     /db_xref="CDD:461550"
     misc_feature    181..1677
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF-4 proto-oncoprotein N-terminal region; Region:
                     AF-4; pfam05110"
                     /db_xref="CDD:461550"
     misc_feature    1603..>2010
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="hypothetical E4 protein; Provisional; Region:
                     PHA03418"
                     /db_xref="CDD:177646"
     misc_feature    1603..>2010
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="hypothetical E4 protein; Provisional; Region:
                     PHA03418"
                     /db_xref="CDD:177646"
     misc_feature    <1894..2292
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <1894..2292
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    2458..2502
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF4 interaction motif; Region: AF4_int; pfam18875"
                     /db_xref="CDD:436798"
     misc_feature    2458..2502
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF4 interaction motif; Region: AF4_int; pfam18875"
                     /db_xref="CDD:436798"
     misc_feature    3025..>3465
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF-4 proto-oncoprotein C-terminal region; Region:
                     AF-4_C; pfam18876"
                     /db_xref="CDD:465894"
     misc_feature    3025..>3465
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /note="AF-4 proto-oncoprotein C-terminal region; Region:
                     AF-4_C; pfam18876"
                     /db_xref="CDD:465894"
     exon            177..297
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..1161
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1206
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1293
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1330
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1382
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1437
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1475
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1629
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2622
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2720
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2967
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3059
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3120
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3254
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3326
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3471
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3695
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..4660
                     /gene="Aff1"
                     /gene_synonym="Mllt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttattttcg ggaagtgaag ttggtttctc gggtctgccg gagcctggat tttcattggc
       61 gtgccctgtg cactctcatc cggctctcct agttggccat ttggcgtcgt cagaagtttg
      121 gaagcgcact taatggaaac taaaattcgc cctggagaga gagggaaatt tgcctgcttg
      181 tacaatgaag acagaaacct gcttcgaatc agagagaagg aaaggcgcaa ccaagaggcc
      241 caccaggaga aagaggcgtt tcctgagaag gctccactgt ttgcagagcc ctacaagacc
      301 gcgaaaggcg atgagctgtc gagtcgcata cagaccatgc taggtgacta tgaagagatg
      361 aaggagttcc taagcagcaa gtcccaccct caccgcctgg acggctctga ggacaggccg
      421 gggaagccca gatacccctc gtgtcacgac cgggggagcg gtgcatccgg ctccttccgc
      481 acacatgtct accaccagcc tacccacact tctgctcccg gatcactttc tgtcagcaac
      541 gtcagccaaa gtccaaagat ggcacagccc aggatggagc cggtgccaag tctccatgcc
      601 aaaatctacg gagcgcccga tggcccccgt ccggctcaag atcgcctcag tcaggggcat
      661 tgttccagaa agtgtgaccg aagagccgag ggagactcgg agaggaagct ctcgcccttc
      721 atctcctcct tgccgtcccc cgtgccccca ctctcacctg cacattccag gccgcaggca
      781 accagcaagg ctcacggcag cggaactggc actcagagct gctatgcctc caagccttcc
      841 aaggacccgg tggtgacggc ccaagagaag gagactcctc tcgacagtct ggtggcagtt
      901 accagccttg gagcagcccc tcctcagcca ccttgccaaa catttccacc acctcccctc
      961 ccctcaaaaa gcatcgcaat gcagcagaag cccacagcgt acgtccgtcc catggacggt
     1021 caggaccagg ctcctagcga gtcccctgag ctgaagccgc cgctggagga ctttggtcag
     1081 caaagctttg agaaaccgga ccttaaagtg cctgccaaag ccaagctcac tagactaagg
     1141 atgccctcgc agacggtaga gcagccgtac tccaatgaag tccactgtgt tgaagagatt
     1201 ctgaaggaaa tgacccactc gtggccgtct cctctgactg ccatacacac acccagtaca
     1261 gccgagccgt ccagatttcc tttccctaca aaggatcctc tgcacatcag ttctgcaacc
     1321 caaagccaaa aacaatacga tgcaccttca aaaacccacc ccaaccccca gcaaggaaca
     1381 tccatgctcg aggatgacct gcagctcagt gacagtgagg aaagcgacgt ggagcaagcc
     1441 gtggagaagc ctccgtcccc acctgcacct ccaagtgctc cgcagacgat tcccgagccc
     1501 gtggcctcag cacattccag tagtgcagag tcagagagca gcgagtcaga cagttcctcc
     1561 gactctgaga gcgagagcag ctccagcgac agtgaggaga acgagcccct ggaaacacag
     1621 gctcccgagc ctgagcctcc gacaacaaac aaatggcagc tggacaactg gttgaccaaa
     1681 gtcaaccaac catcagtgcc cctagagagc cgggggagca cagagtctcc acgatgtcgc
     1741 caggaaagta agggtggtgg tgagggcagc agtgaccagc agcatcctga ttccaaagac
     1801 cctcccctga agagttccag caaagctctc cggggtccct ctgaggggcc gcagcctggg
     1861 aagaggaact gtccgaagtc ccctgctcaa caggaaaccc ccccacctcg gcaaactgtg
     1921 ggcagtaaac aacccagaaa acccaccaag ggctccaccc aggcagagca gccccaggcc
     1981 agctctcgag tggagggcga agcaggaccc gtagcctatg gctcaaagga gcagacatcc
     2041 aaagacaaac ccaaggtgaa gacgaaaggc aggccccgtg ctgtgggcag tcgggagccc
     2101 aaatctgagg tccccgtacc tgtgcctcag gcagctgtgc ccaagccgca gccacctgcg
     2161 cccaccccca tcgagaagag gaaacataag agttccacag ccccctccaa ggcactctca
     2221 ggccctcagc caaccaagga cagtgctggg gacaggaacc aggagcaccc tgcccttgtc
     2281 tccttgactc agagccaggg tcaacccaac agcggcaggg gcagcggtgg tggcaggact
     2341 agtggttgcc ggcaggccgt gatcacccag gaggacagct gtagagacaa gctcctgttg
     2401 cctttgagag acaccaaact gctctcgccg ctcagggact ctccaccacc gacaagcttg
     2461 gtggtgaaga taaccttaga ccttctcacg agggttccgc agccaccggg gaaggggggc
     2521 cgccccagga agtcagagca caagcagctg ccagcaggga agaagcagga cttggaggca
     2581 aggggctgtg acagttccag ccgagtcacc aagaagagaa aggctgaacc ggagaaagag
     2641 cacagtcaca agaggctccg actggataag tcgcagacgt cctcatcctc gtcttcccac
     2701 gcagagtctt ccaagtcaaa gacacccagg ccctcctcag agtgctcaag aaaggaaatg
     2761 cttcctcctc cgccggtggt gccctcatcc tcgtcgtctt cctcgtcttc ccagaagcca
     2821 agcaaacctg cacacaagag gcccaggcca gatgcagaca tcggtagcca ggaccctccc
     2881 agaagttctg gcagcacgaa gagcagctgt acagactctt cagttccgaa gcacagaaaa
     2941 gtacaggccc gggactctga acacaaagga tcttctggag atgctgcgaa tccttttcca
     3001 gtgccttctt tgccaaatgg taactctaag ccaggaaagc cacaggtgaa atctgacaga
     3061 caacaagctg actttcacat gaaggaggct aaaaagctga agtgcaaggc ggaggcaatg
     3121 gtggacaagg ctggaaaagc cttcaagtat ttggaagccg tcctgtcttt tattgagtgt
     3181 ggaatggcca ccgagtcaga gagttcagcg aagtcagcgt acaccgtgta ctcagaaacc
     3241 gtagacctca ttaagttcgt gatgtcgctt aaatccttct cagataacac agtgccagca
     3301 caagagaaga tatttgctgt cttatgcttg cgttgccagt cccttttgaa catggcgatg
     3361 ttccgatgta aaaaggacac ggtgatgaag tattcccgta cccttagcga gcacttcagg
     3421 agtacctcca aagtggccca ggcaccttct ccatgcgtgg caaggcaagt tcacaggcgt
     3481 tccgtccccc gtctccccaa tgccttctcc tgccagctct gctggatccc agacgagtgc
     3541 tggcagcagt atgggggcca tgggggcgac ggccaccgtc agcaccccgg tcaccatcca
     3601 gaacatgacc tcctcttatg tcaccatcac atcccatgtc cttaaggcct ttaccctttg
     3661 ggaacaggca gaggccctca caaggaagaa caaagaattc tttgctcagc tcagcacaaa
     3721 agtgcgcgtg ttggccctca acagcagcct ggtggacctg gtgcactaca caaggcaggg
     3781 cctccagcgg ctgagacaag caccccaaac cccgctaatg taggctgggc ctactcgatg
     3841 ccttgtgcct ctctgcacag ttggaagccg tgatccactg tagacaattg tcagatgggg
     3901 atgtcagtac tcgagaagag gagcgccgtg aggccgtgag acgaccagga tgctcgacca
     3961 cttcaactca caggagctgt gtggtcattg gccggacact ggtcagctca gcagttgctg
     4021 gaaaatgatc ttgcctttcc aaagggaagg acacaagtgc aatggagtcc agctggcgta
     4081 cgaattggtc cagaaacatt tctgggtttt gttttttttt tctgtttgtc tgaacaagag
     4141 gataaaaatt gcaaacaaga ggaagagaac gtctcagaag ccacccttgt tcacttccgg
     4201 aaggagtttt tttttttttt tccggagctg gggaccgaac ccagggcctt gcgctcccta
     4261 ggcaagcgct tttttttttt ttaataataa tttttggtga agggctttat gattttgttc
     4321 tcttctcaag ttttaaagga aacgttgctt aatacattct aatggccatc tgtggaacac
     4381 aagttgcgga ggactccacc gcacctcact tcctgcaggg aaggggctct gatgaccgag
     4441 tactgtcatt tacaaaatct aaggtgacac ccaccgtacc ccagtgccta gagtgctgca
     4501 cattgtctag ctcaggcctc tctggctata ctgagaagca tcccccgtcg gccctagagg
     4561 agtggaagca gttacatccg ggttctttct cacagtcttc ctcacatccc cagaggcctc
     4621 actcttcctc ctgccgcact ccacgaaaaa ccttgggcaa
//
LOCUS       NM_001191587            7499 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus BCL6 co-repressor-like 1 (Bcorl1), mRNA.
ACCESSION   NM_001191587 XM_002730291 XM_039099670
VERSION     NM_001191587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7499)
  AUTHORS   Xu,Q., Zhu,Q., Zhou,Z., Wang,Y., Liu,X., Yin,G., Tong,X. and Tu,K.
  TITLE     MicroRNA-876-5p inhibits epithelial-mesenchymal transition and
            metastasis of hepatocellular carcinoma by targeting BCL6
            corepressor like 1
  JOURNAL   Biomed Pharmacother 103, 645-652 (2018)
   PUBMED   29679906
  REMARK    Erratum:[Biomed Pharmacother. 2023 Jul;163:114804. doi:
            10.1016/j.biopha.2023.114804. PMID: 37121830]
REFERENCE   2  (bases 1 to 7499)
  AUTHORS   Zhao,X., Tuo,H., Si,M., Wang,L. and Liang,P.
  TITLE     [Expression and clinical significance of BCL6 corepressor-like 1 in
            non-small cell lung cancer]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 (12), 1677-1681 (2015)
   PUBMED   26648304
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Mar 27, 2025 this sequence version replaced
            XM_039099670.2, NM_001191587.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000021.1  132394717-132394842
            127-206             JAXUCZ010000021.1  132396142-132396221
            207-336             JAXUCZ010000021.1  132415425-132415554
            337-427             JAXUCZ010000021.1  132421502-132421592
            428-3712            JAXUCZ010000021.1  132421842-132425126
            3713-3878           JAXUCZ010000021.1  132428940-132429105
            3879-3959           JAXUCZ010000021.1  132430120-132430200
            3960-4346           JAXUCZ010000021.1  132432135-132432521
            4347-4570           JAXUCZ010000021.1  132437939-132438162
            4571-4792           JAXUCZ010000021.1  132442476-132442697
            4793-4959           JAXUCZ010000021.1  132444908-132445074
            4960-5105           JAXUCZ010000021.1  132446204-132446349
            5106-5183           JAXUCZ010000021.1  132454062-132454139
            5184-5334           JAXUCZ010000021.1  132455168-132455318
            5335-7499           JAXUCZ010000021.1  132460254-132462418
FEATURES             Location/Qualifiers
     source          1..7499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..7499
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="BCL6 co-repressor-like 1"
                     /db_xref="GeneID:302810"
                     /db_xref="RGD:1566108"
     exon            1..126
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            127..206
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            207..336
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    239..241
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="upstream in-frame stop codon"
     CDS             251..5617
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /codon_start=1
                     /product="BCL-6 corepressor-like protein 1"
                     /protein_id="NP_001178516.1"
                     /db_xref="GeneID:302810"
                     /db_xref="RGD:1566108"
                     /translation="MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQ
                     HFGSQEFCVSSSFSKVELTAVGSGSNARGTNPDGSTTEKLGHRSEDQPDDPQAKMDYV
                     GNTAEAEGLLVPLSSPGDSLKLPTPDGTEASHSRANCSWTPLSTQMSKQVDCSPAGVK
                     ALDSRHSVGEKNTFILATLGTGVPVEGTLPLVTTNFSQLPAPICPPAPGSASGTPSVP
                     DPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLS
                     VSASVLVPVPVSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPSAPTLVLASVP
                     TPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTP
                     APTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPNQPLV
                     YIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSV
                     ARPLASDSKLVSLEVNRLSCTSPSSSTNSQPAPEGVPGPLADTSLTTASAKVLPTSQP
                     LLPAPSGSSVPLHPSKMPGGTDQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDL
                     SSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRTTQAAGSNVTSCLGS
                     TSSPFVIFPEMVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNLGLNR
                     DPRHLPKQEPISIIDQGEPKSTGVTCGKKGSQVAAEGQPSTVKSRYTPARIAPGLPGC
                     QTKELSLWKPTGLTNMYPRCSINGKPTSTQQVLPVGWSPYHQASLLSIGISSAGQLTP
                     SQGVPLRPTSIVSEFSGVSSLGSSEAVHGLPEGQPRPGGPFAPEQDAVTKNKTCRIAA
                     KPYEEQVNPVLLTLSPQTGTLALSVQPNSGDIGVNQGSEESESHLCSDSTPKVEGPQA
                     ACGLKLAGDTKPKSQVLATYMSHELVLANPQNLCKMPELPLLPHDSHSKELILDVVPS
                     SERGPSTDLSQLGSQVDLGRVKMEKADGDVVFNLANCFRADGLPAVPQRGQAEARAKA
                     GQARVKREGVGVFTCKNSWQPDEETESLPPKKVKCNKEKEIEEEPQQQLPPQPHDKPM
                     VRSSVGSKCRKLPGDPQEPTKKSPRGALDSGKEHNGVRGKHKHRKPTKPESLPAGKRA
                     DGHEEGSLEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFTGLADSDMGSQEVFPTEEE
                     EEVAPTPAKRRKVRKTQRDTQYRSHHAQDKTLLSQGRRHLWRAREMPWRTEAARQMWD
                     TNEEEEDEEEEGLVKRKKRRRQKSRKYQTGEYLTEQEEQRRKGRADSKARKQKTSSQS
                     SEHCLRNRDLLLSSKAQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMANVS
                     EEARSKGRWSQQKTRSSKSPTPVKPTEPCTPSKYRSAGSEETSESPTARQIPPEARRL
                     IVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILN
                     ILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS
                     DNMKRFLSDHLSDLQGRAEGDPRASWDFYSSSVLEKKDGFACDLLHNPPGSAEQGDDS
                     EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEIT
                     TLPKAEFYRQVASSQLLTPAERPGSLEDRSPPGSSETVELVQYEPELLRLLGSEVEYQ
                     SWSS"
     misc_feature    <851..2158
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <851..2158
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <4745..5095
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <4745..5095
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    4751..4846
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    4751..4846
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(4754..4756,4766..4771,4778..4786,4790..4795,
                     4805..4807,4817..4819,4844..4846,4850..4852,4856..4858,
                     4868..4873,4880..4888,4892..4897,4907..4909,4916..4918,
                     4943..4945,4949..4951,4955..4957,4967..4972,4979..4987,
                     4991..4996,5006..5008,5015..5017)
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(4754..4756,4766..4771,4778..4786,4790..4795,
                     4805..4807,4817..4819,4844..4846,4850..4852,4856..4858,
                     4868..4873,4880..4888,4892..4897,4907..4909,4916..4918,
                     4943..4945,4949..4951,4955..4957,4967..4972,4979..4987,
                     4991..4996,5006..5008,5015..5017)
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    4850..4945
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    4850..4945
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    4949..5038
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    4949..5038
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    5255..5596
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="PCGF Ub-like fold discriminator of BCOR-like 1;
                     Region: PUFD_like_1; cd14260"
                     /db_xref="CDD:271223"
     misc_feature    5255..5596
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="PCGF Ub-like fold discriminator of BCOR-like 1;
                     Region: PUFD_like_1; cd14260"
                     /db_xref="CDD:271223"
     misc_feature    order(5261..5263,5267..5299,5303..5305,5309..5311,
                     5336..5344,5348..5350,5471..5476,5480..5482,5489..5491,
                     5555..5557,5588..5590,5594..5596)
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="RAWUL domain interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271223"
     misc_feature    order(5261..5263,5267..5299,5303..5305,5309..5311,
                     5336..5344,5348..5350,5471..5476,5480..5482,5489..5491,
                     5555..5557,5588..5590,5594..5596)
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /note="RAWUL domain interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:271223"
     exon            337..427
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            428..3712
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3878
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            3879..3959
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4346
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4570
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            4571..4792
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            4793..4959
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..5105
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            5106..5183
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            5184..5334
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..7499
                     /gene="Bcorl1"
                     /gene_synonym="RGD1566108"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcccagc ggcctgatcc cagcaccccc cctccccgcc acctccctcc tactcccgct
       61 tcgcccgctt cccgggcggt gtggagaaga gcaaagttgc gacagcagcc agggggctct
      121 gcccagggtc agcgtagtta aggacagcta gtgtcagagg aaaagtagac accagtccaa
      181 ctacggccgc ccccactaat acttcggggg agtggccaca gcagatccta tctggtggtg
      241 agtggctgtc atgatctcta cagcaccgct ctacagcggc gtgcataact ggaccagttc
      301 tgaccggatt cgcatgtgtg gcatcaacga ggagagaaga gcacctcttt ctgatgagga
      361 gtccacgaca ggtgactgcc agcactttgg atctcaggag ttttgtgtca gcagcagttt
      421 ttccaaggtg gagctcacgg cagttggaag tggcagcaat gcccggggga caaacccaga
      481 tggcagtacc acagaaaagc ttgggcacag gtcagaagac cagcctgatg atcctcaggc
      541 aaaaatggac tatgttggga atacagcaga ggcggaggga ctcctggtgc cgctgagcag
      601 cccgggagac agccttaagc tgcccactcc tgacggcact gaggctagcc acagcagggc
      661 caactgctcc tggactcccc taagcaccca aatgagcaaa caggttgact gctctccagc
      721 cggggtaaag gctttggact ctcggcacag tgttggggag aagaacactt tcattttggc
      781 aactctggga actggagtcc ccgtggaggg aaccctgcct ctagttacca caaacttcag
      841 tcagctgccg gcacctatct gccctcctgc ccctgggtcg gcctccggga ccccctcggt
      901 tcctgatcca ttccaagttc ccctttctgt cccagcccca gttccccact caggactagt
      961 tccagtccag gttgccacat cggcttcagc tccttcccct cccctagcac cagtgcctgc
     1021 tctagcccca gcagcaccct cggtgcctac tctcatctct gattccaacc ctctctctgt
     1081 gtcagcctct gtcttggtgc ctgtgccagt gtctgctccc cactcagtcc ctgtgccctt
     1141 gtcagctcct gctcctaccc ctctcacagt ctctgtgtct gcacctccct tggctctgat
     1201 ccaggctccc gtgcctcctt cagctcccac tttggtcctt gcttctgtcc cgactccagt
     1261 tctagctccc atgccagcat ccacacctcc agcagctcct gcccctccgt ctgtaccaat
     1321 gcccactccg accccgtcct ctggcccgcc ctctaccccc acccttattc ctgcctttgc
     1381 tcctacaccg gtgcctgcgc ccaccccagc cccaatcttt actccagccc ccacacccat
     1441 gccggctgcc acaccagctg ccatccccac ctcagcaccc attccagcct ccttcagttt
     1501 gagtcgagtg tgctttcctg cagctcaggc accagctatg caaaaagtcc ccctgtcttt
     1561 tcaaccaggg acagtgctga cccctaacca gccgctggta tacatcccac ctccgagttg
     1621 cggccagcca ctcagcgtgg ctacactgcc aaccactctg ggagtgtctt ccacgctcac
     1681 cctcccggtc ctgccatctt acctgcagga caggtgtctc ccgggtgtgt tggcctctcc
     1741 agagctccgc tcttatccat atgcattttc tgtggcccgg cctttggctt cagattcaaa
     1801 gttggtgtct ttagaggtga acaggctctc ctgtacttcc ccatccagca gcactaacag
     1861 ccagcctgca cctgaagggg tccctggacc tttggcagat acctccctca ccactgcttc
     1921 tgccaaggtg cttccaactt cacagccttt gctgccagcc cccagtggga gttcagtccc
     1981 actacacccc tccaagatgc caggtggcac cgatcaacaa acagaaggga cttccgtcac
     2041 cttctctcct ctcaagtcac ctccacagct ggagagagag atggcctctc cacccgagtg
     2101 cagcgagatg cctcttgacc tctcctccaa gtccaaccgc cagaagcttc cattgccgaa
     2161 ccagcggaaa acacctccca tgcctgtgtt gacccctgtg cacaccagca gcaaggccct
     2221 cctttccaca gtcctgtcta ggtctcagcg tacaacccaa gctgccggca gcaatgttac
     2281 ttcctgccta ggctccacct cttcaccttt tgttatcttt cctgagatgg ttaggaatgg
     2341 agacccaagc acctgggtaa aaaactcaac tgctctgatc agcaccattc ctggcacata
     2401 tgtgggagtg gccaacccag tgcctgcatc cctgctgttg aacaaggacc ctaacctggg
     2461 ccttaaccga gatcctaggc atctccccaa gcaggagccc atctccatca ttgatcaagg
     2521 agagcctaag agcactggtg tcacttgtgg caagaaaggc agccaggttg ctgccgaggg
     2581 acagccaagc acagtcaaat cccgttatac cccagcccgc attgcccctg ggctaccagg
     2641 gtgccaaacc aaggaactgt ctttgtggaa acctacaggg ctgacaaata tgtacccacg
     2701 gtgttccatc aatgggaagc ccacgagcac ccaacaggtt ctgcctgttg gctggtcacc
     2761 ataccaccaa gcatctctgc tttcgattgg catttctagt gccgggcaac taacccccag
     2821 tcagggggtg cctctcaggc ccaccagcat tgtttctgag ttttctggtg tgtcatctct
     2881 tggttccagt gaagctgttc atggacttcc tgaggggcag ccacggcctg ggggcccctt
     2941 tgccccagag caggatgctg tcacaaagaa caaaacttgc cgaattgctg ccaagcctta
     3001 tgaagaacaa gtcaatcctg tgcttttgac tctcagccct cagacgggga ccctggcact
     3061 gtctgttcag cctaacagtg gggacattgg agtaaatcag gggtctgagg aatctgagag
     3121 ccacctctgc tctgatagta ctcctaaggt ggaaggcccc caggcagcct gtggcctgaa
     3181 gctggcaggg gacacaaagc ctaaaagcca agtgctggct acctatatgt cccacgagct
     3241 ggtcctggcc aacccccaga acttgtgcaa gatgcctgag ctgcctttgc tacctcatga
     3301 cagccactct aaggaactca ttttagatgt ggttcccagc agcgagagag gccccagcac
     3361 agatctttcg cagcttggaa gtcaggtgga tctgggacgg gtgaaaatgg agaaagcaga
     3421 tggcgatgtg gtcttcaatt tagccaactg cttccgggct gatggactcc cagcagttcc
     3481 ccagaggggc caggctgaag cgcgggctaa agctggacaa gctcgtgtga aacgggaagg
     3541 tgttggggtc tttacttgca agaacagttg gcagccagat gaagagacag aatctctgcc
     3601 acccaagaag gtcaagtgta acaaagaaaa ggaaatcgag gaagaaccac agcagcagct
     3661 gccaccacaa ccacatgata agcccatggt ccggagttcc gtggggtcca agtgccggaa
     3721 gctgcctgga gacccccagg aacccaccaa gaaaagcccc agaggggctt tagattcagg
     3781 aaaagagcac aatggggtca ggggaaagca caagcaccgg aagccaacaa agccagagtc
     3841 cctgcctgca ggaaaacgag cagatggtca tgaggaaggt tccttggaaa agaaagcaaa
     3901 gagcagtttc cgtgacttca tcccagtagt tctgagtact cggacacgca gtcagtctgg
     3961 aagcatctgc agttccttca ctggtctggc agacagtgac atgggaagcc aggaggtctt
     4021 ccctacagag gaagaggagg aggtggcccc caccccagcc aagagaagaa aagtcagaaa
     4081 gacccaaagg gatacccagt accgcagcca tcatgcccag gacaagaccc tgctgagcca
     4141 aggccgcagg catctgtggc gagcccgaga gatgccctgg aggacagagg ctgcccgtca
     4201 aatgtgggac actaacgaag aggaggaaga tgaggaggaa gagggcctcg tgaagagaaa
     4261 gaaacggaga cggcaaaaga gccgaaaata ccagacgggg gagtacctga ctgaacaaga
     4321 agaacagagg cggaaaggga gagcagattc aaaggcccgt aagcagaaga cttcctccca
     4381 aagttcagag cactgcctca ggaacaggga ccttctcttg tccagcaaag cccaggggat
     4441 ctcggactca ccaaatggtt tccttccaaa taacctggag gagccagcct gccttgaaaa
     4501 ttcagaaaag ccatcaggaa aacgaaagtg caagaccaag cacatggcaa acgtctcaga
     4561 agaggcaagg agcaaaggtc gttggagcca gcagaagaca cgatcttcta aatctcccac
     4621 tccagtgaag cccacagaac catgtacacc ctctaagtac cgaagtgctg gctcagaaga
     4681 gacctcagag tcacccactg cccgacagat tcccccagag gcacggagac ttatagtgaa
     4741 taaaaatgct ggggagacgc tcctgcagcg agcagctcgt ctgggttata aggacgttgt
     4801 tctctactgc ctccaaaagc acagcgagga tgtgaatcac cgtgacaacg cgggctacac
     4861 agccttgcac gaagcctgtt cccggggctg gactgatatc ctgaacatcc tattgcaaca
     4921 tggggctaat gtgaactgca gctcacagga tggcacaagg ccagtgcatg atgctgtagt
     4981 caacgacaac ctggaaacca tctggctctt gctatcctac ggagctgatc ccacattggc
     5041 tacctactcg ggtcagacag ccatgaagct ggccagcagt gataacatga agcgctttct
     5101 cagtgatcac ctctccgatc ttcagggcag ggcagagggc gaccctcgtg catcctggga
     5161 tttttacagc agttctgtgt tggagaagaa agacgggttt gcctgtgacc tcctccataa
     5221 ccctcctggg agtgctgagc aaggggatga ttcagaacag gatgacttca tgttcgaact
     5281 ctcagacaag cctcttctcc cttgttacaa cctccaagtg tcagtgtccc gtggaccctg
     5341 caactggttc ctcttcagtg atgtcctgaa gagactgaag ctttcatcac gaatctttca
     5401 ggcccgcttc ccacacctcg agatcaccac cctgccgaag gctgagttct acaggcaggt
     5461 ggcctcaagt cagctgctga cccctgctga gaggcctggg agcttggagg acagatctcc
     5521 cccgggctcc tcagagactg tggagctggt gcagtatgag ccagagctgc tgcggctcct
     5581 agggtctgag gtggaatatc agtcatggag cagttgacgg aaacagcccc tcctccccgt
     5641 tcttctttct ccttcgagtt caccctttcc ccaccgctca tgtctccccc accgagcacc
     5701 agactgcaga atgaggcaat aatatggacc aacaagaagc cgccttatca atgccagcat
     5761 tagtgactgg atttctttct ctctcttttt tgttgggggg tttacagtta gttctcatct
     5821 ccctgttgtt gttgtggttg gttggtgatg gggtggaaat ttgaactcca cttctgaaga
     5881 caagaggtct ggagatggtg ggaggtggca ccagggtccc tcggactggc ttctatgctt
     5941 atgaccaaga ccaaacatgg gcctgggtgg ctatagcctg tcctaaggag aaatgagaaa
     6001 aacccaaatc tcttgagtgc cccttttgtc tccctgtgct cttctgtctt ccatagtatt
     6061 tattttatta gtatttaatt tgtattgttc cattggtttc tgagaagtct gtatcactgt
     6121 gactatttga gacaacttgt tgtatggagg gactttcttt ctttacctcc ctttcccttt
     6181 tctttctaca taagctttgg ggatgctccc accctctgag aaaattattc ccaggttctc
     6241 tctctccatt tggagaggga gcagggtgag gaagaatggg gccatcctct gactaaacaa
     6301 cctatctgct gcctgcccag agctgggggg ctgggggcaa atccctggcc tttggtgctg
     6361 ccccacccct gccagtttca ctccaccccg ccctctgtag cttccatctt gagtgtttac
     6421 cagggagcag cattcccgag ttaactctaa taaaggcagg ttgagagacc tgaggcaagg
     6481 tgctcccctc acagtgctcc gctcagtgca cagtaaactt attctgacat cttttgccct
     6541 gtacccctcc cctacttgcc tcacctaccc ccggggctcc ccatcttgag atagtgagcc
     6601 tttcacctcc cagactttgc cctgccatcc ctcccacaga cttgtagccc ctctacccct
     6661 ctctcctcca cctgcccttg gttctccttt ggaatctcta aagggccctg ggactaacta
     6721 ggtgaaggca agggaccagt ctttagcagt ctctagcctg gctccatagc cactcaggga
     6781 ctgagtgagt ggctcctagg ccttcaggcg cctagttaga tctgttacca tagaggggga
     6841 caggaggagc ttgggttgtt tccctggccc cacccctccg tggcattgcc cctccccctc
     6901 ttatttttct accgattgct atttttccga acaatcctag tagagagtgt gtaccatcca
     6961 aaggcaggag ggcctcactg tgggtggctc tggatggaga gggtacagtt ttattgtaca
     7021 ggtgctaaac atcaacaaaa gaagaaaatg gggaaagaca aaaaaaaaaa aaagaggaaa
     7081 aaaaaccagt ttggggatgg gacaatctgt tctctggagg ctcctgatcc acttaggagc
     7141 actatttctt ttaactgtgt gtggtttttt gttcccgggg gaatttctga gcccccttct
     7201 gtaggacagc ccatcatcct acccaaatgg ttttgaacaa ttgttttccc tttttaacag
     7261 caacaagatt atatatatat agatatacat atatatatga agttgagggg gtttggattt
     7321 caattttgtt ttgttggaaa ttatactgtg tggtttgttt tctggttttt ttgtttgttt
     7381 tttttttggt tttgttttct ttttggtttt gcattttggt gtgtattctc gctgcccttt
     7441 atgtttcgtt ttaagcaact ggctgtggag tcaaaaacac ttgcatactg aaaaacctg
//
LOCUS       NM_001437135            2879 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus P2Y receptor family member 10 (P2ry10),
            transcript variant 2, mRNA.
ACCESSION   NM_001437135 XM_063280021
VERSION     NM_001437135.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 27, 2025 this sequence version replaced XM_063280021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663597, SAMN13663609
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000021.1  76194395-76194469
            76-227              JAXUCZ010000021.1  76227029-76227180
            228-324             JAXUCZ010000021.1  76265716-76265812
            325-2879            JAXUCZ010000021.1  76277303-76279857
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2879
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="P2Y receptor family member 10"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
     exon            1..75
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     exon            76..227
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    179..181
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="upstream in-frame stop codon"
     exon            228..324
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     exon            325..2879
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1360
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="purinergic receptor P2Y, G-protein coupled, 10;
                     purinergic receptor P2Y10"
                     /codon_start=1
                     /product="putative P2Y purinoceptor 10"
                     /protein_id="NP_001424064.1"
                     /db_xref="GeneID:317219"
                     /db_xref="RGD:1561912"
                     /translation="MGSNSTSTVESNCNAINVTFQNSLYATTYIFIFIPGLLANSAAL
                     WVLFRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKY
                     LNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAAVWIIVGTACLPFPIMRS
                     AGLANNTDSCFADLGYKQMDPLVLVTMITIAELAGFVIPVLTIACCTWKTTVSLKHPP
                     IAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKENIITSCPIVKSAMYFH
                     PFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVS"
     misc_feature    440..1288
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    440..1288
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    446..520
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    446..520
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    545..610
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    545..610
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    656..724
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    656..724
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    788..838
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    788..838
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    926..997
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    926..997
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    1064..1132
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1064..1132
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1190..1267
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1190..1267
                     /gene="P2ry10"
                     /gene_synonym="RGD1561912"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
ORIGIN      
        1 agtgacagat ttcccccttg tactggctcc atcaccagtc ataatctgac taccgagagg
       61 aaaagcagtg gtcagataca caagaagagg gcgccagatc ctgttccaga tgggtgtgag
      121 ccaccatgtg gttgcttggg attgaactca cgacctctgg aagagcagtc agtgctccta
      181 actgctgagc catctctcca gcccaagaca gtcttttcaa tacaacttta tcagcaggat
      241 atgtgcttgc tgcccagact tgtacatttt tactcccatc tctttgcaaa tatacaggac
      301 tccttattcc agctcagcat cagggaacca taattccaca gtttttcttg atgaacatac
      361 tgagatattc aagatgggca gcaatagcac cagcactgtt gagagtaatt gcaatgccat
      421 taatgtgaca tttcagaact ctctgtatgc aaccacctac attttcatat tcatcccggg
      481 tctcctggct aacagtgcag ccctgtgggt tctgtttcgc ttcatcagca agaagaataa
      541 agccatcatt ttcatgatca acctctcagt ggcagacctt gctcatatcc tgtccttacc
      601 tcttcggatt tactattata tcaatcgtca ctggccattc cagagggccc tttgcctgct
      661 gtgcttctat ctgaaatatc tcaacatgta tgccagcatt tttttcttga cctgcattag
      721 ccttcagagg tgcctctttc ttctcaagcc attcagagcc agaaactgga agcggaggta
      781 cgacgtaggc atcagtgctg ctgtctggat cattgtgggg actgcctgtt tgccatttcc
      841 catcatgaga agtgctggct tagctaataa cacagactca tgctttgctg atcttgggta
      901 caaacagatg gatccattgg ttctggtcac catgattaca attgctgaac ttgctggatt
      961 tgtgattcca gtgctcacaa tcgcatgttg tacctggaaa acaactgtat ccttgaaaca
     1021 cccaccgatt gcttttcaag ggattagtga gaggaaaaaa gcattgcgga tggttttcat
     1081 gtgtgctgca gtcttcgtca tctgcttcac tccttatcac attaacttca ttttttacac
     1141 catggtaaag gaaaacatca ttaccagttg tcccattgtg aaaagtgcca tgtatttcca
     1201 tcctttttca ctgtgccttg caagtctctg ttgtcttttg gacccgattc tgtattattt
     1261 catggcttca gagtttcgtg accaactatc tcgccatggg agctctgtta ctcgttctcg
     1321 tctcatgagc agggaaagtg gttcatccat ggttagctaa aaccagataa ttcttcagtt
     1381 aggattctct ttacctaatg ttctgtggcc tcgtccaaag gcaggaattg ccaggcaaat
     1441 tatttcttta actgaacctt ggaaatagaa gaaaaagctt tcttgtgtga tagttgtggt
     1501 ctccacagat gaaggaagca taatgtgaaa aaaatgtggg agtaaaaata aaaataagat
     1561 ccatgtgctt ccaacttaca atttatgaca ttctattagt tacaagtctc agatcaagat
     1621 caagttttta acagatgttt ccatccaaat ataaattgaa tgcatgtatt tacatttgtc
     1681 ttctgtaaat agaatagtac tgagttgcca gatatatatt aatctttaca aaaaagtaaa
     1741 tgtccaccat ggaataattt tatttctgaa tgaataaaag atttcaggtc tttctaaaac
     1801 attaaacagg gacaaagtga cacaaaggtt acaaaaatgt gtgaatgaat tttagcactg
     1861 cattcttgct actgaatgca gcgcatgaaa atgcactcat tggatgttta tagatgttta
     1921 ttattttcta ggttgggagt ttgctatgta tttttacaaa gaacatctca tcttactttt
     1981 tcaatacaag tgacaataaa tgtggaaatt acaaatacaa atgaataaat gtaacagccg
     2041 agaggttaaa caacatgcct caggattaac agttaagtat acatggcata tgtttatatt
     2101 attgcctctg cttatatttt tatattaatt aagtcaatac caagtttgag tttaatgctg
     2161 aagatgcaaa ctgaagataa gcatagtagg tatggataat tttaacacaa tgttcttggg
     2221 ctcatcaata aatccatatg ttgaggatta gcatgatact ggttagcgta ttctatgata
     2281 aatatattgt cctattagtg taatcatctg tatagtcttg atgagaagaa acttagtagt
     2341 tcattatttc aaagtcaatt ttatggctta atataagcca tgcaaatctc ataaaataga
     2401 aagctatgaa actgagccac attttagaaa atgtaggttt ccacttaaaa attctccatt
     2461 aaaaatactt atagtatatg taactaaata aaatctcaag ggttttctga tatcagaact
     2521 cacacaattg cactagaacc agagaaatat tatcacattg tgaataaata tgagagaaat
     2581 atgtgaactt atttttttct taaagttaca gataatattt taagtgttca tatagatcat
     2641 acaaatacaa cagacccctt agcttttcag gttgacaatt aactggcatt ttatgtctga
     2701 aattaacaga gcgtagacat ttggggtgca ggcaagaaaa ggaagtggta ggcatgcatt
     2761 tgtgaagact aaggaagagg aagggaccac aaaaggagga attaaaaaga acatttgttg
     2821 gtttctttga ccatgagata gttctgtaat tataatgtaa taaagctttt ttaattgga
//
LOCUS       NM_001437148            1479 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus nanos C2HC-type zinc finger 3 (Nanos3),
            transcript variant 1, mRNA.
ACCESSION   NM_001437148 XM_006255235
VERSION     NM_001437148.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Bhandari,D., Raisch,T., Weichenrieder,O., Jonas,S. and
            Izaurralde,E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Julaton,V.T. and Reijo Pera,R.A.
  TITLE     NANOS3 function in human germ cell development
  JOURNAL   Hum Mol Genet 20 (11), 2238-2250 (2011)
   PUBMED   21421998
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Suzuki,H., Tsuda,M., Kiso,M. and Saga,Y.
  TITLE     Nanos3 maintains the germ cell lineage in the mouse by suppressing
            both Bax-dependent and -independent apoptotic pathways
  JOURNAL   Dev Biol 318 (1), 133-142 (2008)
   PUBMED   18436203
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Lolicato,F., Marino,R., Paronetto,M.P., Pellegrini,M., Dolci,S.,
            Geremia,R. and Grimaldi,P.
  TITLE     Potential role of Nanos3 in maintaining the undifferentiated
            spermatogonia population
  JOURNAL   Dev Biol 313 (2), 725-738 (2008)
   PUBMED   18089289
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006255235.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2399938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1222              JAXUCZ010000019.1  40889531-40890752
            1223-1479           JAXUCZ010000019.1  40893454-40893710
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1479
                     /gene="Nanos3"
                     /note="nanos C2HC-type zinc finger 3"
                     /db_xref="GeneID:288909"
                     /db_xref="RGD:1306672"
     exon            1..1222
                     /gene="Nanos3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    673..675
                     /gene="Nanos3"
                     /note="upstream in-frame stop codon"
     CDS             766..1290
                     /gene="Nanos3"
                     /note="isoform 1 is encoded by transcript variant 1; nanos
                     homolog 3"
                     /codon_start=1
                     /product="nanos homolog 3 isoform 1"
                     /protein_id="NP_001424077.1"
                     /db_xref="GeneID:288909"
                     /db_xref="RGD:1306672"
                     /translation="MGTFNLWTDYLGLARLVGALHEEEEPDVRLDPKPEPKPSSASQQ
                     ASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHA
                     HTRRFCPLTGQGYTSVYCYTTRNSAGKKLTRPDKAKTQNAGHRLGGEAAAGSKSGRKP
                     PGPSPSACCPSTTA"
     misc_feature    934..1095
                     /gene="Nanos3"
                     /note="Nanos RNA binding domain; Region: zf-nanos;
                     pfam05741"
                     /db_xref="CDD:461728"
     misc_feature    934..1095
                     /gene="Nanos3"
                     /note="Nanos RNA binding domain; Region: zf-nanos;
                     pfam05741"
                     /db_xref="CDD:461728"
     exon            1223..1479
                     /gene="Nanos3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcctccaac cttgaacttt tcagcccaac actccccctc cccccgcccc cttcccttta
       61 taatccagac attctggtgt ctctttctct tcctctcctg ttttcttctc tcttatctgt
      121 gctcatgccc tttttctctc cttttcttcc ttccttcttt cctttaattc acatcttaag
      181 actaagttct ccaggtcatg aaagaccctt agtgaaacct tagagactct gttgtcattt
      241 ccctgccccc agccccactt ccaggctcag gcctccttcc taggtattgg gattgctgct
      301 ttgctgattt agcaagaact caaggccaca tgtcaccccc acctcccacc cccccacccc
      361 ccacccccac cccccgcctt agggaagaca ggaaaaaaaa aaaagtaaac cacctgtcag
      421 tgtttagccc tggagcagaa ctcttagccg tccacttacc tctgcaccta cgtgccagca
      481 ggggttgacc tcccacagga aggggggagg agaccttggg gaagcttggg ggttcaatgg
      541 ctccagtctg cctctggcta ccttcagccc acacaaacac catatacccc ctgggcaggt
      601 gtgtaagaag ccccctgtga caatgaggac cccccaagcc tgcctgctcc accctttcac
      661 accccctcaa ggtaaaagaa aagcagccag agaaggctga gcttcagggt aggagggaag
      721 ttggagcctg gctgggtttc ttctctgctg ctcctctggc cggccatggg aacttttaat
      781 ctttggacag attacctagg tctggcaaga ctggttgggg ctctgcatga ggaagaggag
      841 cctgatgtca ggctggaccc caaaccagag cccaagccaa gctcagcaag ccagcaagcc
      901 agcaaggaat cctcagcagc tccagaacgc ctatgttcat tctgcaaaca caatggcgag
      961 tctcgtgcga tctatcagtc ccatgtcctg aaggatgagg cagggcgggt gctgtgtccc
     1021 atcttgcgag attatgtgtg tccccagtgt ggggccactc aggagcatgc ccacactcga
     1081 cgcttctgcc cactcaccgg ccagggctat acttctgtct actgctacac cacccggaat
     1141 tctgcaggca aaaagctgac ccggcctgac aaggcaaaga cacagaatgc tggccaccgc
     1201 cttggaggag aagcagcagc aggttccaaa agtggcagga agccccctgg accttcaccc
     1261 tcggcctgct gtccctccac tacggcctag gagcttggag tggggaggac catggtggca
     1321 ccgttgtcag gggtctggac acaggcatgc tggagactgg accttgctta ggattgaggc
     1381 tggccacagt cttgtcagag gttaccttcc ccaaccctgg ccctgcttgt gttgttgcct
     1441 cagtgtctaa taaatgctaa gaagtggagc ctgtcctgg
//
LOCUS       NM_001437155            3933 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2),
            transcript variant 1, mRNA.
ACCESSION   NM_001437155 XM_006239246
VERSION     NM_001437155.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3933)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3933)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3933)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3933)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3933)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3933)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3933)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_006239246.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20921.1,
                                           SRR26643290.21177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000005.1  158575755-158575931
            178-272             JAXUCZ010000005.1  158580731-158580825
            273-455             JAXUCZ010000005.1  158580935-158581117
            456-514             JAXUCZ010000005.1  158582423-158582481
            515-629             JAXUCZ010000005.1  158582568-158582682
            630-709             JAXUCZ010000005.1  158582908-158582987
            710-787             JAXUCZ010000005.1  158583894-158583971
            788-857             JAXUCZ010000005.1  158584121-158584190
            858-992             JAXUCZ010000005.1  158584860-158584994
            993-1059            JAXUCZ010000005.1  158585080-158585146
            1060-1191           JAXUCZ010000005.1  158585223-158585354
            1192-1347           JAXUCZ010000005.1  158587265-158587420
            1348-1458           JAXUCZ010000005.1  158588430-158588540
            1459-1505           JAXUCZ010000005.1  158588624-158588670
            1506-1694           JAXUCZ010000005.1  158588750-158588938
            1695-1901           JAXUCZ010000005.1  158589800-158590006
            1902-1991           JAXUCZ010000005.1  158590386-158590475
            1992-2151           JAXUCZ010000005.1  158590555-158590714
            2152-2272           JAXUCZ010000005.1  158590833-158590953
            2273-2397           JAXUCZ010000005.1  158591073-158591197
            2398-2558           JAXUCZ010000005.1  158591857-158592017
            2559-2675           JAXUCZ010000005.1  158592132-158592248
            2676-2755           JAXUCZ010000005.1  158592331-158592410
            2756-2908           JAXUCZ010000005.1  158592944-158593096
            2909-3005           JAXUCZ010000005.1  158593200-158593296
            3006-3229           JAXUCZ010000005.1  158593909-158594132
            3230-3381           JAXUCZ010000005.1  158594217-158594368
            3382-3551           JAXUCZ010000005.1  158594521-158594690
            3552-3933           JAXUCZ010000005.1  158594779-158595160
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3933
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..177
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="upstream in-frame stop codon"
     CDS             168..3689
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable cation-transporting ATPase 13A2; ATPase type
                     13A2; polyamine-transporting ATPase 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2 isoform 1"
                     /protein_id="NP_001424084.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLV
                     CELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR
                     EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMS
                     RTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVP
                     APDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGL
                     ILVPGLLQGPLGLRNIADSSFKLLLLGLVAFNFVGAFMLESVLDQCLPACLQWLRPKR
                     ASKKQFKQLQRELAERPWPTLPVGSVR"
     misc_feature    282..3515
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     misc_feature    282..3515
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="P-type ATPase of unknown pump specificity (type V);
                     Region: P-ATPase-V; TIGR01657"
                     /db_xref="CDD:273738"
     exon            178..272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            456..514
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            515..629
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            630..709
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            710..787
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            788..857
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            858..992
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1059
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1191
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1347
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1505
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1694
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1901
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1991
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2151
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2272
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2397
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2558
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2675
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2755
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2908
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3005
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3229
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3381
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3551
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3933
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgactg cggcatcgtt ccagtcacgg tcgcgtcgtg caggtgccgc ccagcccggc
       61 ccctccgaag ctcgcctcag tcggtgtccc cgaccgtgcc ccggggcctc gcacgccgag
      121 cccaggccgc gggccacagc ggccggcgat gagcgcgagg agtcgaaatg agcgcagaca
      181 gcagcccgct cctgggcagc acgcccccca gctatgggac cctgatgaca gggacatcaa
      241 tcgatcccct cagctcctca gtttcatccg tgaggctcag cggctactgt ggcagtccat
      301 ggagggccat cggctatcac gccgcggtct ggatgctggc cgggatccct tggctgctat
      361 tccgctggaa gcccttgtgg ggcgtgcgcc tgcgcctgag gccatgcagc ctggcccgcg
      421 ccgaaacact cgttatagaa ataagagaca aagagggtag ctccagacag ctcttcactg
      481 tccaggtgca gactgaggct gttgtcgacg gcagcctgga gctgccctca caggccaagg
      541 cagaggatgg ccggagcctg gcggccgtgg gagtggcacc ggagagcatg tggcaggaca
      601 ctacgcagct ccacaggcag aaagaggcaa agcaggtact gcgctattac atcctccagg
      661 gccaacgcta tgtctggatg gagacccagc aagccttctg ccaagtcagc ctgctggacc
      721 acggtcgtgc ctgcgatgac atccattgct ccagttctgg cctcagcctc caggaccagg
      781 ctgtgaggaa gaccatttac ggccccaacg tgattggtat tcccgtcaag tcctacctgc
      841 agctactggt ggatgaggca ctgaacccct actacggatt ccaggccttc agcatcgccc
      901 tgtggctggc tgaccactac tactggtatg ctgtctgcat cttcctcatc tcggccatct
      961 ccatctgcct gtctctctac aagaccagga agcaaagcat gactctgagg gacatggtca
     1021 agttgtccgt gcgggtgcag gtgtgccgac ccggaggaga ggaagagtgg gtggactcca
     1081 gtgagctggt gcccggagac tgcctggtac tgccccagga gggcggaatg atgccgtgtg
     1141 atgctgctct ggtggccggg gagtgtgtgg tcaatgagag ctccctgaca ggagaaagca
     1201 tcccagtgtt gaagacagcc ctgccagagg ggccccagcc ctactgccca gagacccacc
     1261 ggcggcacac tctcttctgt ggcaccctcg ttctgcaggc ccgggcctac ctgggacccc
     1321 gtgtcctagc cgtggtaact cggacagggt tctgcacagc caaagggggc ctggtgagct
     1381 ccatcctaca cccacggccc atcagcttca agttctacag acacagcatg aagtttgtgg
     1441 cagcgctgtc cgtcctggct ctgctcggta ccatctacag catcatcatt ctctaccgaa
     1501 accgggtgcc cgtgaaggag atcgtgatcc gagctctgga cctggtgacg gtggtggtac
     1561 cacccgccct gccggccgcc atgaccgtgt gcacactcta cgcccagagc cggctgcgta
     1621 cacagggcat cttctgtatc cacccgctgc gcatcaactt ggggggcaag ctgcgcctcg
     1681 tgtgcttcga caagacaggc accctcacgg aggacggatt ggacataatg ggggtggtgc
     1741 ccctaaaggg gcagatgttg ctgccactgg tcccagagcc ctgccacctg cccccagggc
     1801 ccctcctccg agcactggtc acctgtcatg ccctcagcca gctacatgat accttggtgg
     1861 gcgaccccat ggatctcaag atggtggagt ctacaggctg ggtcttagag gagggttcgg
     1921 ctgcaggctc agcacctgag acccaggtct tggtggtaat gcgaccccca cccagggggc
     1981 ctcagcaaca ggaagagtca ccagagccag tcagtgtcct ccgccgcttc cccttctcct
     2041 ctgccctgca gcggatggac gtggtggtga catggccagg ggccacccag cctgaggcct
     2101 acgtcaaagg ttccccagag cttgtggcca gcctctgcag ccccgagaca gtgcccagag
     2161 actttcctca ggtactgcag agctacacag ctgctggcta ccgagttgtg gccctggctg
     2221 gcaagccact gcccactgcg cccagccttg aggccgctca gcagctgaca agggacactg
     2281 tggagcagga gctgagcctc ctggggctgc tggtcatgcg gaacctgctg aagccacaga
     2341 cgaccccagt tatacagacc ctgaggaaga cgggcatccg tactgttatg gtgacagggg
     2401 acaacctgca gacagcagtc acggtggcca aagcgtgtgg catggtgggc acccaggagc
     2461 acctggctat catccatgcc acccaccctg agcagggcca gcctgctgcc cttgagttcc
     2521 tgccaactga gccctctgcg gccatgaatg gggcaaagga tcctgtgcag gccacggact
     2581 accccgtgga gccggagtcc cagtcccgtc acctggccct cagtgggtcc acgtttgctg
     2641 tccttcagaa gcacttcccc aagctgctgc ccaaggtcct ggtgcaggcc accgtctttg
     2701 cccgcatggc cccggagcag aagacacagc tagtgtgtga acttcagaga cttcagtact
     2761 gcgtgggcat gtgcggggat ggagccaatg actgtggggc cctgaaggcg gctgacgtgg
     2821 gcatctcact gtcccaggca gaggcctcag tggtctctcc gttcacctcc agcatggcca
     2881 gtattgaatg tgtgcccact gtcatcaggg aaggccgctg ctctctggac acttcattca
     2941 gcgtcttcaa gtatatggcc ctatacagcc tgacccagtt catctctgtc ctcattctct
     3001 acacaatcaa caccaacctg ggagacctac agttcttggc catcgacctg ttcatcacca
     3061 ccacggttgc cgtgctcatg agccgcaccg gccctgcact gaccttggtg cgagcacggc
     3121 caccaggggc gctgctgagc gtgcctgtac ttggcagttt gctgctgcag gtggccttgg
     3181 tggccggcat ccagcttggg ggctactttt tggtcatagc tcagccctgg tttgtgcctc
     3241 tgaacagaac tgtacccgca cctgacaacc tgcccaacta cgagaacaca gtgatcttct
     3301 ctctgtctgg cttccagtac ctcatcctgg ccgcagcggt gtctaagggg gcacccttcc
     3361 gccagccgct ctacaccaac gtgcccttcc tggtggccct ggcgctcttg ggctctgtcc
     3421 tggtgggcct catcctggtc cccggcctcc tgcaggggcc actaggactg aggaacattg
     3481 cggacagctc tttcaagttg ctgctgctgg gtctggtcgc cttcaacttt gtgggcgcct
     3541 tcatgctgga gagcgtgctg gaccagtgtc tcccagcctg cctgcagtgg ctgcggccta
     3601 aacgggcctc caagaagcaa ttcaagcagc tacaacggga gcttgctgaa cgtccatggc
     3661 ccactctgcc cgttggctcc gtgaggtagt gcaggccttg gagggcatgc tggacactgg
     3721 atctccctgc ccctgagcca tgaccggaac tctccctaga gacagtacca gtcacctccc
     3781 acagccctga ggttggctgt cacactcctg gggacacact cgcctgggga ggcgttgatt
     3841 gttgcctcac tgtgtagaga cagcagctac caactccatc cggagcagct gtcatggagc
     3901 aaataaagtg ccggctttcc tgtcttggca gca
//
LOCUS       NM_001437141             688 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus ciliary microtubule inner protein 3 (Cimip3),
            transcript variant 4, mRNA.
ACCESSION   NM_001437141 XM_039084500
VERSION     NM_001437141.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039084500.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.413344.1,
                                           SRR26360190.782975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000009.1  21074406-21074500
            96-164              JAXUCZ010000009.1  21079517-21079585
            165-688             JAXUCZ010000009.1  21080119-21080642
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..688
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="ciliary microtubule inner protein 3"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
     exon            1..95
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="upstream in-frame stop codon"
     CDS             87..515
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /note="isoform 3 is encoded by transcript variant 4;
                     Guca1a neighbor"
                     /codon_start=1
                     /product="putative uncharacterized protein CIMIP3 isoform
                     3"
                     /protein_id="NP_001424070.1"
                     /db_xref="GeneID:100912849"
                     /db_xref="RGD:6485345"
                     /translation="MLKIIDTKDGSRGCHYQKWTLERTEKESQKSLIPGHRQKTTSGR
                     KGKKVPPPTPTPLSQKWKRDRKQSLESAYVPVVVDPRGQEPDSSFRFNFYNSQYSNSL
                     NPFYTLQKPTCGYLYQRETDHTRKCFGIPPANLVLWRSTY"
     exon            96..164
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
     exon            165..688
                     /gene="Cimip3"
                     /gene_synonym="Guca1anb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccctcc cgagactccc cagatgcctc tggatcccta accaccagaa gttccatttt
       61 accatcaaag aggaaactga ccaaagatgt tgaaaataat agacacaaaa gatggatcac
      121 gcggttgtca ctaccaaaag tggactttgg agcgaacgga aaaggagtca cagaaatcct
      181 taatccccgg tcaccggcaa aagacgacat caggcagaaa ggggaagaag gtgccgccgc
      241 ccacaccaac accattgtca cagaaatgga aacgggaccg caaacagtct ctggagtcag
      301 cttatgtccc cgtggtggtg gatcctcgcg ggcaggagcc agacagtagt ttcaggttca
      361 atttctacaa ctcacagtat tccaactctc tcaatccctt ctacaccctg cagaaaccca
      421 cctgtggtta cctgtaccag agagaaactg accacacacg gaaatgcttt ggcattcctc
      481 ccgcaaacct ggtcttgtgg cgcagcacct actaaatcca aggcatctgg aagtccccac
      541 cctgcacctt cactctgtgg tcctgggtcc cagagggaaa agtcattcat tcctggagaa
      601 gcggcgtata cctgggctag ccaggtatgc tgtgacagct gagggaggcc tcttcccaat
      661 aaacttcagt ccttcttttt ttctggca
//
LOCUS       NM_001437145             826 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus single-pass membrane protein with coiled-coil
            domains 4 (Smco4), transcript variant 1, mRNA.
ACCESSION   NM_001437145 XM_017595724
VERSION     NM_001437145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 27, 2025 this sequence version replaced XM_017595724.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.575308.1,
                                           SRR26360186.736926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  20594710-20594770
            62-138              JAXUCZ010000008.1  20627474-20627550
            139-826             JAXUCZ010000008.1  20646229-20646916
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..826
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
     exon            1..61
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            62..138
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     exon            139..826
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..399
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_001424074.1"
                     /db_xref="GeneID:363020"
                     /db_xref="RGD:1309410"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPIVTE"
     misc_feature    220..384
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
     misc_feature    220..384
                     /gene="Smco4"
                     /gene_synonym="RGD1309410"
                     /note="Domain of unknown function (DUF4519); Region:
                     DUF4519; pfam15012"
                     /db_xref="CDD:464444"
ORIGIN      
        1 agaggcgagg cgggcgagcg gctgcccctg ccacgtaccc ggccgtgcgc ggcggcggca
       61 ggaagaactc aggtcaccct gactggaaat cagttgaccc acgtcagtga agcagtggtt
      121 cctgaatttg aagaaaagag gtggtctgcc cggacagagg agtgtggccc tttcttcaag
      181 ccctctctgc acatctcttc ccagcatcct ctaaccaaga tgcgtcagct caaagggaag
      241 ccaaagaaag agacctccaa ggacaagaag gagcggaagc aggccatgca ggaggcccgg
      301 cagcagatca ccactgtggt gctgcctacc ttggctgtgg tggtgctcct cattgtagtg
      361 tttgtgtacg tggccacgcg ccccatcgtc accgagtgag caccgccatc ctggctttcc
      421 tctgcagaca tgtctgcaat gccgagctct gggcaggagt gccctgtctc ctctgatctt
      481 tgacttgatc aatatttctc tacttttggg ggggaaggga aagggaacat ttatcagtga
      541 atgtgccatt tacccgatgg tccacttcat gtgcctttca gacttcaaag cagtgcgtgt
      601 gtgcgtgtgc gtgtgcgtgt gtgcgtgcgt gtctcccctt ttctcctgaa atcgacgcac
      661 agctgcacct ggggagagga ggcctctccg ggtgacactg tgcttcctgg ctccgttcac
      721 agctttctaa ggggacagcc tttcttctct gtacttgatg ggatgtgaaa tacgctgact
      781 caaagtgaaa tatttatttt tgaataaagg agataatagt cttaaa
//
LOCUS       NM_001437163            3559 bp    mRNA    linear   ROD 30-MAR-2025
DEFINITION  Rattus norvegicus Rho guanine nucleotide exchange factor 19
            (Arhgef19), mRNA.
ACCESSION   NM_001437163 XM_039110425
VERSION     NM_001437163.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3559)
  AUTHORS   Caddy,J., Wilanowski,T., Darido,C., Dworkin,S., Ting,S.B., Zhao,Q.,
            Rank,G., Auden,A., Srivastava,S., Papenfuss,T.A., Murdoch,J.N.,
            Humbert,P.O., Parekh,V., Boulos,N., Weber,T., Zuo,J.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Epidermal wound repair is regulated by the planar cell polarity
            signaling pathway
  JOURNAL   Dev Cell 19 (1), 138-147 (2010)
   PUBMED   20643356
  REMARK    Erratum:[Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_039110425.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.2158715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000005.1  158824724-158824785
            63-506              JAXUCZ010000005.1  158825771-158826214
            507-791             JAXUCZ010000005.1  158826553-158826837
            792-900             JAXUCZ010000005.1  158826971-158827079
            901-977             JAXUCZ010000005.1  158827147-158827223
            978-1240            JAXUCZ010000005.1  158827421-158827683
            1241-1401           JAXUCZ010000005.1  158828534-158828694
            1402-1554           JAXUCZ010000005.1  158828775-158828927
            1555-1684           JAXUCZ010000005.1  158829086-158829215
            1685-1759           JAXUCZ010000005.1  158829558-158829632
            1760-1849           JAXUCZ010000005.1  158829719-158829808
            1850-2010           JAXUCZ010000005.1  158829943-158830103
            2011-2169           JAXUCZ010000005.1  158834095-158834253
            2170-2249           JAXUCZ010000005.1  158834500-158834579
            2250-2354           JAXUCZ010000005.1  158835976-158836080
            2355-3559           JAXUCZ010000005.1  158836370-158837574
FEATURES             Location/Qualifiers
     source          1..3559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3559
                     /gene="Arhgef19"
                     /note="Rho guanine nucleotide exchange factor 19"
                     /db_xref="GeneID:362648"
                     /db_xref="RGD:1304766"
     exon            1..62
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Arhgef19"
                     /note="upstream in-frame stop codon"
     exon            63..506
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2512
                     /gene="Arhgef19"
                     /note="Rho guanine nucleotide exchange factor (GEF) 19"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 19"
                     /protein_id="NP_001424092.1"
                     /db_xref="GeneID:362648"
                     /db_xref="RGD:1304766"
                     /translation="MDCGPPATLQPHLAGPPGTARRPVAVCQQESLSFVELPTLHPPS
                     PVCVDLFPITPEELQAPGSRWSLATPAPLQGLLWPTSSGGPDTHISTTGGMRPSRAGS
                     WPHCPGAQPPTLVGPWSSQHMQPQRRASHGGSEKSAWRKMQVYHNEEATGGTEPPMGL
                     LETGQAVQGQALCAQEPRPQELSGNTRGGLEAQERRRFSASELMTRLHSSLRLGRSTA
                     PRALTSGSGAGVIREGKLPGREPRRAETRMDSVSLPAPVDLNEVQGGLVEPRLDTNDK
                     PTQDTNSATERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDGAEGAEEGPGP
                     PRANLSPSSSFRAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSE
                     ASYIHSLSVAVGHFLGSVELSECLGTQDKQWLFSKLPEVKSTSERFLHDLEQRLEADV
                     LRFSVCDVVLHHCPAFRRVYLPYVTNQAYQERTYQRLLLENPKFPGILARLEESPVCQ
                     RLPLTSFLILPFQRVTRLKMLVENILKRTTPGSQDEDMATKAFSALKELVQECNASVQ
                     SMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAV
                     YLHLFNDCLLLSRRKELGKFAVFVHANMAELQVRDLSLKLQGIPGHVFLLRLLHGQRA
                     RHQLLLRARTESEKQRWISALRPSSPQEDKEITCDGEDRPQVQCVRTYKALQPDELTL
                     EKTDILAVKTRTSDGWLEGVRLADGEKGWVPQAHVEEISSLSARLRNLREYKRVSNVS
                     SKLGDPPA"
     misc_feature    1247..1777
                     /gene="Arhgef19"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1247..1777
                     /gene="Arhgef19"
                     /note="RhoGEF domain; Region: RhoGEF; pfam00621"
                     /db_xref="CDD:459876"
     misc_feature    1841..2221
                     /gene="Arhgef19"
                     /note="Ephexin Pleckstrin homology (PH) domain; Region:
                     PH_ephexin; cd01221"
                     /db_xref="CDD:269929"
     misc_feature    1841..2221
                     /gene="Arhgef19"
                     /note="Ephexin Pleckstrin homology (PH) domain; Region:
                     PH_ephexin; cd01221"
                     /db_xref="CDD:269929"
     misc_feature    2258..2422
                     /gene="Arhgef19"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    2258..2422
                     /gene="Arhgef19"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(2273..2275,2279..2281,2288..2290,2300..2302,
                     2354..2359,2402..2404,2408..2413)
                     /gene="Arhgef19"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(2273..2275,2279..2281,2288..2290,2300..2302,
                     2354..2359,2402..2404,2408..2413)
                     /gene="Arhgef19"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     exon            507..791
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            792..900
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            901..977
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1240
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1401
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1554
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1684
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1759
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1849
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2010
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2169
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2249
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2354
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..3559
                     /gene="Arhgef19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacaggg cttcccctgc cggagcaggc aggctgcagc agcagcagct tcaactgaag
       61 aggcccggga gggtggcaga ggaaaggagg aatggactgt ggaccacctg caaccctcca
      121 gcctcacctg gctggaccac ctggcactgc ccgtcgccca gtagccgtgt gccagcaaga
      181 gagcctgtcc tttgtggagc tgcccaccct gcaccctcca agcccagtgt gtgtggacct
      241 ctttcccatt actccagagg agctacaagc ccctggtagc cgctggtccc tggcgacccc
      301 tgcccctctc caaggactgt tatggccgac atcctcagga ggcccagata cccatatctc
      361 caccactgga ggaatgaggc ccagcagggc tggcagctgg cctcactgtc ctggtgccca
      421 gcccccaact ctggtgggac cctggagttc tcagcatatg cagccccaac gaagggccag
      481 ccacggtggc tcagagaagt cagcctggcg caagatgcag gtgtatcata acgaagaggc
      541 cacaggcggc acagagcccc ccatgggcct tctggagact ggccaggctg ttcaagggca
      601 ggctctgtgt gcgcaagagc cccggccaca ggaactttct gggaacacca gagggggcct
      661 tgaggcacag gagagaagac gtttctcggc ctcagagctg atgactaggc tgcattcttc
      721 tctccgtttg gggcgcagca cggcccctag agctctgacc tcgggctcag gtgctggagt
      781 catccgggaa gggaaactgc ccgggaggga accccgaaga gccgagacga ggatggacag
      841 tgtgtccctg ccagcacccg tcgatctaaa tgaggtccag ggtggtctgg tggagcccag
      901 gttggacacg aacgacaagc cgactcaaga taccaacagt gccactgagc gacgccagtc
      961 ccgtttcctc cttaactctg tcctctacca ggagtacagc gacgtggcca gcgcgcgcga
     1021 attgcggcgg cagcagcgcg aggaggaggg ccccggggac ggggcggagg gcgcggagga
     1081 ggggcccggg ccaccgcgcg ccaacctctc cccgagcagc tctttccgcg cgcagcgctc
     1141 gacgcgaggc tccaccttct cgctgtggca ggacatcccc gacgtgcgcg gcagcggcgt
     1201 cctggccacg ctgagcctgc gcgactgcaa actgcaggag gccaaatttg agctgattac
     1261 ctcggaggcc tcctacatcc atagcctgtc ggtggccgtg ggtcacttct taggttccgt
     1321 ggagctgagc gagtgtctgg ggactcagga caaacagtgg ctattttcca aactccccga
     1381 ggtcaagagc accagtgaga gatttcttca cgacctggaa cagcgtctgg aggccgacgt
     1441 gctgcgcttc agcgtctgtg atgtggttct gcaccactgc cccgccttcc gccgggtcta
     1501 cctgccctac gtcaccaacc aggcctatca ggagcgcacc taccagcgcc tgctcctaga
     1561 gaaccccaag ttccccggca tcctggctcg cttagaggag tctcctgtgt gccagcggct
     1621 gcctctcacc tcattcctca tcctaccgtt ccagagggtc acccgcctca agatgctggt
     1681 ggagaacatc ttgaagcgca cgacaccggg ctcccaagat gaggacatgg ctaccaaggc
     1741 cttcagtgca ctaaaggagc tggtgcagga atgcaacgca agcgtgcagt ccatgaagag
     1801 gaccgaggag ctcattcacc tgagtaagaa gatccacttc gagggcaaga tcttcccgct
     1861 gatctcacag gcccgctggc tggtacggca cggggagctg gtggagctgg ccccgctgcc
     1921 cgccgcacca ccagccaagc tgaagctgtc cagcaaggct gtgtaccttc acctcttcaa
     1981 tgactgcctg ctgctgtccc ggaggaagga gctcgggaag tttgccgtat ttgttcatgc
     2041 caacatggct gagctacagg ttcgagacct cagcctgaag ctccagggca tccccggcca
     2101 tgtattcctg ctcaggctgc tgcatgggca gcgcgccagg caccagctgc tgctgagggc
     2161 acggacagaa agcgagaagc aacggtggat ttcggccttg cgtccatcca gcccccagga
     2221 agacaaggag atcacttgtg atggggaaga ccgcccccag gtccagtgtg tgaggactta
     2281 caaggccctg cagcccgatg aactgacctt ggagaaaaca gacatcctag cagtgaagac
     2341 taggaccagc gatggctggc tggagggtgt gcgactggcc gatggtgaga aggggtgggt
     2401 gcctcaggcc cacgtggagg agatcagcag cctcagcgct cgactgcgta acctccggga
     2461 gtacaagagg gtctccaacg tcagcagcaa gctgggggac ccgcccgcct gatgctccgc
     2521 tggggccact ctggtgctgg tgggcttctg tgtgtctgag ggccgcaggg tggcaacggt
     2581 tctgtaaata cactctggct gcctctgctc agtctgagcg gggcgggcct tctcatgggc
     2641 tgccccatca ggagggcact ggttgttcct gctgtcactc gtcccaaggg cagaggggct
     2701 gccccaacct gctactttcc cctccaagta gcaagtgtca gatccaagca ggcttgaata
     2761 ttaaagtgac tccgtgagtt tctgtagttg cctcttgtgg cctgtgccaa gaaagcacca
     2821 ccagctgggg ggtagccttg aaactattaa agcatagctc agaggccagg ctctcaaatc
     2881 ggcctcctgg gctgggctcc aggtggaggt gatgctgggc cccatctggg tctcaggaga
     2941 aaatcgcttg ttgcctctgt gtacttggtg gttgccagtg agctgcactt gcagacaaat
     3001 cccagtccta ctgtgtgtcc tctgtctgcc cgggactgtg agcctatggc ttcatttgga
     3061 gtctccccca cccaccctca accatctccc catcacagtc ctggaaaaaa catcgacaaa
     3121 catacttctt ccgtgttttc ttgttttgtt ttgcttattt gtttaaaaac ctttttaaat
     3181 gtactttatg tgaatgggtg tctgatggca tctggttata tgcaccctgt acatgtaata
     3241 cctagggagg ccagaagagg gtgacagatc ccgtgaaact ggagttacag atggttgtga
     3301 gccaccatgt gagggctggg aaccaaaacc aggtcccagc cagcacactt aatcccggag
     3361 cgacctctcc agcccccaac atacactttg gtagcaccta cctttcatcc cagcactcag
     3421 gaggcagagg cgggtagatc tctgagttca aggccagtct ggtctatagt tttctaggac
     3481 agccagggtt ccacagaaaa caaacaaaac aaccacagaa tttaactttc ctaaatccct
     3541 ggaataaaga cataaacat
//
LOCUS       NM_001012230            3687 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus XK related, X-linked (Xkrx), mRNA.
ACCESSION   NM_001012230 XM_577015
VERSION     NM_001012230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 27, 2025 this sequence version replaced NM_001012230.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.68360.1, AY534257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680416, SAMN06680419
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1477              JAXUCZ010000021.1  101646013-101647489 c
            1478-1746           JAXUCZ010000021.1  101641731-101641999 c
            1747-3687           JAXUCZ010000021.1  101634441-101636381 c
FEATURES             Location/Qualifiers
     source          1..3687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..3687
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="XK related, X-linked"
                     /db_xref="GeneID:497101"
                     /db_xref="RGD:1359223"
     exon            1..1477
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1116..1118
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="upstream in-frame stop codon"
     CDS             1146..2492
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="X Kell blood group precursor related X linked; XK,
                     Kell blood group complex subunit-related, X-linked"
                     /codon_start=1
                     /product="XK-related protein 2"
                     /protein_id="NP_001012230.1"
                     /db_xref="GeneID:497101"
                     /db_xref="RGD:1359223"
                     /translation="MDRVYEIPEEPNVVPIASLEDVIRGPNPRFTFPFSILFSTFLYC
                     GEAASALYMVRIYRKNNETFWMTYTFSFFMFSSIMVQLTLIFVHRDLAKDRPLSLFMH
                     LILLGPVIRCLEAMIKYLTLWKKEGQEEPYVSLTRKKMLIDGQEVLIEWEVGHSIRTL
                     AMHRNAYKRMSQIQAFLGSVPQLTYQLYVTLISAEVPLGRAVLMFFSLISVTYGATLC
                     NMLAIQIKYDDYKIRLGPVEVLCITIWRTLEITSRLMILVLFSATLKLKAVPFLVLNF
                     LIILFEPWVKFWRSGAQMPNNIEKNFSRVGTLVVLISVTILYAGINFSCWSAMQLKLA
                     DRDLVDKGQNWGHMGLHYSVRLVENVIMVLVFKYFGVKVLLNYSHSLMAIQLIIAYLI
                     SIGFMLLFFQYLHPLRSLFTHNVVDYLHCICCRRHHRERVENSETSCEPDTRQSIV"
     misc_feature    1245..1307
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    1248..2363
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="XK-related protein; Region: XK-related; pfam09815"
                     /db_xref="CDD:462912"
     misc_feature    1248..2363
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="XK-related protein; Region: XK-related; pfam09815"
                     /db_xref="CDD:462912"
     misc_feature    1344..1406
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    1434..1496
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    1662..1724
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    1752..1814
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    1947..2009
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    2058..2120
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    2211..2273
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     misc_feature    2286..2348
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GH60.1);
                     transmembrane region"
     exon            1478..1746
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..3687
                     /gene="Xkrx"
                     /gene_synonym="XRG2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagacaca cctgcctaac tgcgtgggtt gagcgagtgt gggagcgagc tactttagct
       61 agctgtggag ggcggggtag aagtgggtgc atgctgctgc tccgggagaa gaggaaaagc
      121 tgtggctccc tcctgaatcc cggagtcatg gtgagaaata ctgctaaaga ctggtgcagg
      181 gtcctttcgt gttgcgcctc gctacctgga gcatcctttg gctattcatc ttggaactct
      241 ggcttatttt gttttatcca gctctctctc ccagccaacg ccaccaccac cccacccaag
      301 tcatccaggt gccatagtta ccaaagccca gaacctgcca cacttctcaa actgtgactt
      361 ttgtagcaaa gtgtctccgt gaagacaccc ctccagcctc ttctatcggg taccacgcac
      421 tgcactcctc cgcttctttc cgaggagaca tcgttgggga cagtggtggc attactttgg
      481 cccccagcca ggcggtctta ggggcggggc ttggagaacc tacttgagaa catttgcctc
      541 cgtacaggtc ctgagagagc tctgctgagc ccgtgagcag gctaacttat aggcacaacc
      601 tagcagcagg ttggatgaaa acctaggtac tgaactgaat ctttgacagg acactcaggc
      661 tgtgctccct cttctacctc ggctcagttc tctgctgact ggaaaggata cacggatgag
      721 aatccctaag gagaagcggc tgaggatgtg atgtacctcc tcaaagtagc tactcccctg
      781 cctggggggc tatgaaagga ggctcggcgg aaacagctgt tccttgcctt ttcacacgcc
      841 tggaattgga caccagactc agtgctggag tgcttgtcca agtttttcag cacatatgtt
      901 gaagattgca ttccagggcc gatcaagagt gaagttcaaa gagatccccc tggactctcc
      961 attccagact cttgagttaa gtctggaatc aaggtgtctc ctgttctgac ttgttgatct
     1021 tcattcaggg actcgactag ccacggttca cctgacttgg acaccagtgg ctacgagggg
     1081 ggagggctct tctagggatg gatggcgaag aactctgaac tccagacgat aagagagtct
     1141 ccacaatgga cagagtttat gaaattcctg aggagccaaa tgtggttcct atcgcatctc
     1201 tggaagatgt catccgtggg cctaacccac gttttacctt tccatttagt atcctcttct
     1261 ccaccttctt gtactgcggg gaggctgcat ctgccttgta tatggttcga atttaccgaa
     1321 agaacaacga gaccttctgg atgacataca ccttttcctt ttttatgttt tcatccatca
     1381 tggttcagtt gaccctcatt tttgtccaca gagacctggc caaagataga ccactatcat
     1441 tatttatgca tctaatcctc ttgggacctg ttatcagatg tttggaggcc atgattaagt
     1501 accttacact gtggaagaaa gaggggcagg aagagccata tgtcagcctc acccgaaaga
     1561 agatgctaat agatggccaa gaagtgctga tagaatggga ggtgggccac tccatccgga
     1621 ccctggctat gcaccgcaat gcctacaaac gtatgtctca gattcaagcc ttcctgggct
     1681 cagtgcccca gctaacctat cagctatatg tgaccctgat ctctgcagaa gtcccccttg
     1741 gtagagctgt gttaatgttt ttttccctga tatctgtcac ctatggggct accctctgca
     1801 atatgttggc tatccagatc aagtatgatg actacaagat tcgacttggt ccagtggaag
     1861 tcctttgtat caccatctgg aggacattgg agatcacttc ccgcctcatg attctggtgc
     1921 tcttctcggc caccttgaag ttgaaagctg tgcccttctt agtgctcaac ttcttgatca
     1981 tcctctttga gccctgggtt aagttctgga ggagtggtgc ccaaatgcca aacaatattg
     2041 agaaaaattt cagccgagtt ggcacgctgg tggtactgat ttctgttacc atcctctatg
     2101 ctggcatcaa cttctcttgc tggtcagcca tgcagttgaa gttggcagac agagaccttg
     2161 ttgacaaagg tcagaactgg ggacatatgg gactgcacta cagtgtgagg ttggtagaga
     2221 atgtgatcat ggtgttggtt tttaagtact ttggagtcaa ggtgttactg aattactccc
     2281 attccttgat ggctattcag cttattattg cttacctgat ttccattgga ttcatgctcc
     2341 tctttttcca gtacttgcac ccattgcgct cactcttcac ccataacgta gtagactacc
     2401 tccattgtat ctgctgccgc agacaccatc gggaaagggt tgagaactca gagacatcct
     2461 gtgagcctga cacaaggcaa agtattgtct gattcttctt ctttttctcc ttcttctcct
     2521 tcttctcctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct
     2581 tcttcttctt cttcttcttc ttcttctcat tatagggtgg gtttggggtt gacaagagca
     2641 actgtgaaat tgaaggagtt ggtgagattc ctgtgtgtga gtacacacag gatcattttc
     2701 ttgactcttc tagtaagcct gttgaaagaa agagtgacct gcaaataggt tttacttctt
     2761 tgtcattgac tgctatgttt ggataccagc actagacact gattttcatt tatcctcatc
     2821 ctagtcaact gaactaacct ccaagtactt cactcaggct ctgaatttct agctctgctc
     2881 atttgtttga ggtattgctg agcttccctg ggttgatcta aactctgtca gaacacatct
     2941 gtactgatcg gagaatgtga tggcttacta ataacgagca cctctcagaa agtaatatga
     3001 ctgttgtgat gcctttaact gtgagagtgg ctgggatatt tgtattccaa tgaggaaccc
     3061 tgtctaagaa ggcggctcca ttattgaaga aagctactcc ccaaatgagt taatacccaa
     3121 tagtatttta ctggtggcca ttcagcaaag acttctcttt taagaaatcc ttcataggca
     3181 ccccctttgg agggtgtgca gaataggatt ccttcctgta gggactgagg caggatctca
     3241 tgtatctcag actgggctca aagttactat atagctaaga atgatgtagc ttgaactcac
     3301 gatttttctg cctttgcctt ctgagtgctg ggattgcaga tgtgtgctac tgcatctggt
     3361 ttatctggtg ctgaggactg aacccaaggc taggcaagca ccatttatat agtactaggc
     3421 actggaattg ggttgagata agagctctac caactgagat atccttggcc cccagaatga
     3481 ctcttgagga gttgtgtagg cctccagcta cattgagaga aatgtttgag tgaaatttct
     3541 cacttggtgc cccattaata gggttcccct ccaatccagc ctttctgtct ctgcattttg
     3601 ttacttgatg taaacctcag agaagctaaa ctataatttg aagtgtttac tgatatgtga
     3661 aataaatgaa gatttctttg tgtctgc
//
LOCUS       NM_001437204            3233 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), transcript variant 4, mRNA.
ACCESSION   NM_001437204 XM_006250806
VERSION     NM_001437204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3233)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 3233)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 3233)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 3233)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 3233)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 3233)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250806.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.559084.1,
                                           SRR26643289.34675.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000014.1  21570427-21570741   c
            316-417             JAXUCZ010000014.1  21560488-21560589   c
            418-746             JAXUCZ010000014.1  21559484-21559812   c
            747-1179            JAXUCZ010000014.1  21558937-21559369   c
            1180-1269           JAXUCZ010000014.1  21556341-21556430   c
            1270-1323           JAXUCZ010000014.1  21555834-21555887   c
            1324-1418           JAXUCZ010000014.1  21555171-21555265   c
            1419-1527           JAXUCZ010000014.1  21553803-21553911   c
            1528-1645           JAXUCZ010000014.1  21553603-21553720   c
            1646-1730           JAXUCZ010000014.1  21550070-21550154   c
            1731-1897           JAXUCZ010000014.1  21548930-21549096   c
            1898-1980           JAXUCZ010000014.1  21546400-21546482   c
            1981-2017           JAXUCZ010000014.1  21545168-21545204   c
            2018-2057           JAXUCZ010000014.1  21545032-21545071   c
            2058-2120           JAXUCZ010000014.1  21544877-21544939   c
            2121-2255           JAXUCZ010000014.1  21543336-21543470   c
            2256-3233           JAXUCZ010000014.1  21540276-21541253   c
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3233
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     exon            1..315
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="upstream in-frame stop codon"
     CDS             288..2480
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="isoform 4 is encoded by transcript variant 4; YTH
                     domain-containing protein 1; RA301-binding protein;
                     putative splicing factor YT521; splicing factor YT521-B;
                     YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1 isoform 4"
                     /protein_id="NP_001424133.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQR
                     SERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDG
                     DDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDS
                     GSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHE
                     KLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNL
                     AFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDW
                     ICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIH
                     KMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGY
                     LKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPGIEQPPHHP
                     YYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPR
                     ERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR"
     misc_feature    288..1310
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    390..392
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    639..641
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    645..647
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    723..725
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    729..731
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1218..1220
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1239..1241
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1245..1247
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1248..1250
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1254..1256
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1362..1772
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1362..1772
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH (YT521-B homology) domains are RNA-binding
                     domains that belong to the PUA superfamily; Region: YTH;
                     cd21134"
                     /db_xref="CDD:410979"
     misc_feature    1566..1568
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1599..1601
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    1821..1985
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1929..1931
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96MU7; propagated from
                     UniProtKB/Swiss-Prot (Q9QY02.2); phosphorylation site"
     misc_feature    2115..2225
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2301..2477
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY02.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            316..417
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            418..746
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1179
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1323
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1418
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1527
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1645
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1730
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1897
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1980
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2017
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2057
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2120
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2255
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..3233
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccgccc gccgtcgcca tctgtttctc tctcctcccc cttgtctctg gtgtggccga
       61 atccccaaca gaaagattga agcccgcgct gtccgaggtc aggcgggaag agaaccagag
      121 gacgggagga agggtgctcg taggagctga gtggagcagg tcaggtcgaa gcgcgcggcc
      181 cgccggacgg actgacggac ggactcgtgc gcctgcggcc gcggctgcgg cgcccgcgcg
      241 actcgcttcc cggcggcggt ggcggcggcg gaagccggag ggcagccatg gcggccgaca
      301 gccgggagga gaaagatggg gaacttaatg ttttagatga tattttgact gaagtaccag
      361 aacaggatga tgaactgtat aatccagaga gtgaacaaga taaaaatgag aaaaaaggat
      421 caaaaagaaa aagtgaaaga atggaatcta ttgacaccaa gcgacagaag ccttctatcc
      481 attcaagaca actgatttct aagccactaa gctcatctgt tagcaataat aaaagaatag
      541 ttagtacaaa aggaaagtcg gttacagaat ataaaaatga ggaatatcaa agatctgaaa
      601 ggaacaagcg tctagatgct gatcgaaaaa ttcgtctgtc aagcagttcc tctagagaac
      661 cttacaagag tcaaccagaa aaaccttgtc tacggaaaag ggattctgaa agaagggcca
      721 agtctcctac accagatggt tctgagagaa ttgggcttga agttgataga cgtgcaagca
      781 gatccagcca gtcttcaaag gaagagggga actctgagga gtatggctct gaccacgaga
      841 caggaagcag tgcttcttct gaacagggca acaacactga gaatgaggag gaaggagggg
      901 aagaagatgt agaggaagat gaagaggtag atgaagatgg agatgatgat gaggaagtgg
      961 atgaagatgc ggaggaggag gaggacgagg aagaagatga ggaggaggag gatgaggaag
     1021 aagaagagga agaggaagaa gaatatgaac aggatgagag agatcagaag gaagaaggga
     1081 atgattatga cacccgtagt gaggccagtg attctggttc tgagtctgtt tccttcacag
     1141 atggatctgt caggtctggt tcaggaacag atggatcaga tgagaaaaag aaggaaagga
     1201 agagagctcg aggcatatca cccattgtct ttgatagaag tggcagttct gcatcagagt
     1261 catatgcagg ttcagaaaag aagcatgaga aattatcatc ttccgttcgt gctgtccgaa
     1321 aagatcaaac cagtaaactc aaatatgtcc ttcaggatgc aagatttttc ctcataaaga
     1381 gtaacaacca tgagaatgtg tctcttgcca aagcaaaggg tgtatggtcc acattacctg
     1441 taaatgagaa gaaattaaat cttgcgttta gatctgcaag gagtgttata ttaatatttt
     1501 ctgtcaggga aagtggaaag tttcaaggtt ttgccagatt gtcatcagaa tcgcatcatg
     1561 gtggctctcc tatacattgg gtgcttccag caggaatgag tgctaaaatg cttggaggtg
     1621 tttttaaaat tgactggatt tgcaggcgtg aattaccctt tactaagtca gctcatctca
     1681 ccaatccctg gaatgaacat aagccagtaa agattggacg tgatggacag gaaattgaac
     1741 ttgaatgtgg aacccagctt tgtcttctgt ttccccctga tgaaagtatt gacttgtatc
     1801 agctcattca taaaatgcgt cacaagagaa gaatgcattc tcagcctcga tcaagaggac
     1861 gtccatcccg tcgagaacca gtccgggatg tgggaaggcg tcgaccagaa gattatgata
     1921 ttcataacag cagaaagaaa ccaaggattg actatccccc tgagtttcac cagagaccag
     1981 ggtatttaaa ggatccccga taccaggaag ttgacagacg attttcagga gttcgccgag
     2041 atgtgttttt aaatgggtcc tacaatgatt atgtgaggga atttcataac atgggaccac
     2101 cgcctccttg gcaaggaatg cctccttacc cgggaataga acagcctcca caccatccct
     2161 actaccagca ccatgccccg cctcctcaag cccacccccc ttactcagga caccatccgg
     2221 taccacatga agcaagatac agagataaac gagtacatga ctatgatatg agggttgatg
     2281 atttccttcg ccgcacacaa gccgttgtca gtggtcggag aagtagaccc cgagaaagag
     2341 atcgggagcg agagcgagac cgccctagag ataacagaag agatagagag cgagacagag
     2401 gtcgtgatcg agaaagagag agagaaagaa tatgtgatcg ggacagagac cgaggggaaa
     2461 gaggtcgtta tcgaagataa tgtgcttttt ggaagcactg actgaagata aaaaatattg
     2521 tatttttttt gtgtgtgttt acaagtagta aatttatttt cagctgtcta cttaaagctc
     2581 attgtgtaga aggatttatt atcttctttg ttccaagcat gcagtagaat aagaactgga
     2641 aaactcagat ccgccaaaaa atgcacagtt gacagttgag ttgacacttt tattggggca
     2701 gaatggaaca gtccaagaat gtagatattg attcattctc cataaatgtt ctttttacag
     2761 tgtattcatc ctagagttat tttgtttgtt tgttttcctt cttttggacc ttggtcaata
     2821 ctgccatagt attttgcttt gtgtttctat aggtagctgc acacggttca gtaaaaataa
     2881 tgctgctatc aagtatgcag atattgagta tgatggtttg actatatggc agtgttgtag
     2941 cagcctctcg gtttctcctc ttccctcctt ttttttaaac ctataaatcc actttttttt
     3001 taagtcttca atgatgagag caatattaag aagacattgc tatctaattt ttaatctttt
     3061 taaataaaac gttcctatgt tcagtagcat ggtcgatgct attgtttagc cttccttcca
     3121 aactgtacat tggcttggaa tgttcagttt tgcgtgtgtg gcagcagaag ataaccccac
     3181 attctacatt gctactgttt tgtatgaaat aaattggtaa agattgacac taa
//
LOCUS       NM_001437181            1382 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus transmembrane protein 240 (Tmem240), transcript
            variant 1, mRNA.
ACCESSION   NM_001437181
VERSION     NM_001437181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Trinidad,J.C., Barkan,D.T., Gulledge,B.F., Thalhammer,A., Sali,A.,
            Schoepfer,R. and Burlingame,A.L.
  TITLE     Global identification and characterization of both O-GlcNAcylation
            and phosphorylation at the murine synapse
  JOURNAL   Mol Cell Proteomics 11 (8), 215-229 (2012)
   PUBMED   22645316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2131922.1,
                                           SRR26360194.1357990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               JAXUCZ010000005.1  171626659-171627001
            344-450             JAXUCZ010000005.1  171627273-171627379
            451-659             JAXUCZ010000005.1  171631449-171631657
            660-1382            JAXUCZ010000005.1  171631731-171632453
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1382
                     /gene="Tmem240"
                     /note="transmembrane protein 240"
                     /db_xref="GeneID:100362471"
                     /db_xref="RGD:2318117"
     exon            1..343
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..808
                     /gene="Tmem240"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 240 isoform 1"
                     /protein_id="NP_001424110.1"
                     /db_xref="GeneID:100362471"
                     /db_xref="RGD:2318117"
                     /translation="MSMSANTMIFMILGASIVMAIACLMDMNALLDRFHNYILPHLRG
                     EDRVCHCNCGRHHIHYVIPYDGDQSVVDASENYFVTDNVTKQEIDLMLGLLLGFCISW
                     FLVWMDGVLHCAVRAWRAGRRYDGSWTWLPKLCSLRELGRRPHRPFEEPTGNMVHVKQ
                     KLYHNGHPSPRHL"
     misc_feature    287..805
                     /gene="Tmem240"
                     /note="TMEM240 family; Region: TMEM240; pfam15207"
                     /db_xref="CDD:405814"
     misc_feature    287..805
                     /gene="Tmem240"
                     /note="TMEM240 family; Region: TMEM240; pfam15207"
                     /db_xref="CDD:405814"
     exon            344..450
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
     exon            451..659
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
     exon            660..1382
                     /gene="Tmem240"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagaggg aggagggagg gggccgccgc gcggaccgca gggagccggg cgcagggagc
       61 accggagggc ggagcggagg gctgccagca acgggcgacg ggcgagcgac cccacaacag
      121 cccccacatc tctgctgcct gtgcccgcgc ctgtccccgg ggtccgcggc ggcccggcgc
      181 gcgagcgctg acctctgcgg aggcggcgcg ggctcagcat cgggccgggg ccgggagggg
      241 caccggggcc ggggggcggc gctccggccc ggcccggccc cgcccgatgt ccatgagtgc
      301 gaacaccatg atcttcatga ttctgggggc gtcgatcgtg atggccatcg cgtgcttgat
      361 ggacatgaac gcgctgctgg accgattcca taactacatc ctcccgcacc tgcggggcga
      421 ggaccgcgtc tgccactgca actgtggccg gcaccacatt cactacgtga tcccatacga
      481 cggggaccag tcggtggtgg acgcctctga gaactacttt gtgacagaca atgtgaccaa
      541 gcaggagatc gaccttatgc tgggcctgct gctgggcttc tgcatcagct ggttcctggt
      601 gtggatggat ggtgtcctgc actgtgctgt gcgcgcctgg agggctggtc ggcgctatga
      661 tggctcgtgg acctggctgc ccaagctgtg cagcctgcgg gagctgggcc ggcggccaca
      721 caggcccttc gaggagccta cagggaacat ggtgcacgtg aagcagaagc tctaccacaa
      781 cggccacccc agcccccggc acctgtgagt gcccaggact cggggctgct gtgcacatgt
      841 aaagggacct cgtggacgcc cagctggcaa gatgggactg cggcctcagg cccagggtat
      901 gctgggctgt ggccagctgg gctgtggcca gcaggcaaat ccagtggaag gtgctgtctc
      961 ttctttttat aaagggggtt gggtgggggc tggggtgggg ctggcctctg ggcttcaggg
     1021 acagcagcct ggtctccaca gtgagcagga cacaaaggca ggctctcaga ggtgctgggg
     1081 ccaggggtgg tgggtccata gtggggagag gcttggcctg gtccacacta gcctaaagcc
     1141 acatctcagt gaaagcactg tttcttgagc acctgttgtc catccgtccg tctggagggg
     1201 agggatgtgt cagggcctgc gcccatctgc acacgggagc atgtgcatgg ggcgtgtgcg
     1261 actggagggt gggactggag gggcgggccc ctagcagcaa taaggatgtg gtggccccag
     1321 gtgtcccagc cctcactgtg aagcccaccc tgcctggcca gtaaattctc cagaaagctc
     1381 ca
//
LOCUS       NM_001437215            4569 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus factor interacting with PAPOLA and CPSF1
            (Fip1l1), transcript variant 6, mRNA.
ACCESSION   NM_001437215 XM_006250887
VERSION     NM_001437215.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4569)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4569)
  AUTHORS   Qu,S.Q., Ai,X.F., Li,C.W., Li,Q.H., Xu,Z.F., Qin,T.J., Zhang,Y. and
            Xiao,Z.J.
  TITLE     [Characteristics of cytogenetics and molecular biology in patients
            with eosinophilia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 20 (5), 1216-1220 (2012)
   PUBMED   23114151
REFERENCE   3  (bases 1 to 4569)
  AUTHORS   Arefi,M., Garcia,J.L., Briz,M.M., de Arriba,F., Rodriguez,J.N.,
            Martin-Nunez,G., Martinez,J., Lopez,J., Suarez,J.G., Moreno,M.J.,
            Merino,M.A., Gutierrez,N.C. and Hernandez-Rivas,J.M.
  TITLE     Response to imatinib mesylate in patients with hypereosinophilic
            syndrome
  JOURNAL   Int J Hematol 96 (3), 320-326 (2012)
   PUBMED   22806436
REFERENCE   4  (bases 1 to 4569)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4569)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4569)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   7  (bases 1 to 4569)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   8  (bases 1 to 4569)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250887.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2333461.1,
                                           SRR26360190.1818591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000014.1  34029545-34029828   c
            285-329             JAXUCZ010000014.1  34028453-34028497   c
            330-369             JAXUCZ010000014.1  34028325-34028364   c
            370-427             JAXUCZ010000014.1  34023443-34023500   c
            428-531             JAXUCZ010000014.1  34022355-34022458   c
            532-596             JAXUCZ010000014.1  34019484-34019548   c
            597-704             JAXUCZ010000014.1  34018785-34018892   c
            705-835             JAXUCZ010000014.1  34018068-34018198   c
            836-945             JAXUCZ010000014.1  34009985-34010094   c
            946-1039            JAXUCZ010000014.1  33995782-33995875   c
            1040-1196           JAXUCZ010000014.1  33994406-33994562   c
            1197-1223           JAXUCZ010000014.1  33983462-33983488   c
            1224-1278           JAXUCZ010000014.1  33981524-33981578   c
            1279-1334           JAXUCZ010000014.1  33980419-33980474   c
            1335-1554           JAXUCZ010000014.1  33976291-33976510   c
            1555-1692           JAXUCZ010000014.1  33972832-33972969   c
            1693-4569           JAXUCZ010000014.1  33969341-33972217   c
FEATURES             Location/Qualifiers
     source          1..4569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4569
                     /gene="Fip1l1"
                     /note="factor interacting with PAPOLA and CPSF1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
     exon            1..284
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Fip1l1"
                     /note="upstream in-frame stop codon"
     CDS             203..1840
                     /gene="Fip1l1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1
                     protein"
                     /codon_start=1
                     /product="pre-mRNA 3'-end-processing factor FIP1 isoform
                     6"
                     /protein_id="NP_001424144.1"
                     /db_xref="GeneID:289582"
                     /db_xref="RGD:1309336"
                     /translation="MSAGEVERLVELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDE
                     NEVERPEEENASANPPSGIEEEAAENGVAKPKVTETEDDSDSDSDDDEDDVHVTIGDI
                     KTGAPQYGSYGTAPVNLNIKAGGRVYGNTGTKVKGVDLDAPGSINGVPLLEVDLDSFE
                     DKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTG
                     NSEKEAALPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENS
                     NIQVLSDRSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIP
                     ITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLTSSAPSWPS
                     LVDTTKQWDYYARREKDRDRDRERDRDRERERDRDRERERTRERERERDHSPTPSVFN
                     SDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEG
                     DSHRRHKHKKSKRSKEGKEAGSEPVPEQESTEAAPAE"
     misc_feature    203..1090
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Necessary for stimulating PAPOLA activity.
                     /evidence=ECO:0000250"
     misc_feature    203..532
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with PAPOLA.
                     /evidence=ECO:0000250"
     misc_feature    203..487
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    452..454
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D824; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    458..460
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D824; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    464..466
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    608..859
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with CPSF4.
                     /evidence=ECO:0000250"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    659..787
                     /gene="Fip1l1"
                     /note="Fip1 motif; Region: Fip1; pfam05182"
                     /db_xref="CDD:461573"
     misc_feature    836..940
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1325..1327
                     /gene="Fip1l1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1376..1837
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Sufficient for interaction with CPSF1 and CSTF3.
                     /evidence=ECO:0000250"
     misc_feature    1418..1525
                     /gene="Fip1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U317.1);
                     Region: Arg/Asp/Glu-rich domain.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15"
     misc_feature    1529..1531
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1535..1537
                     /gene="Fip1l1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1541..1543
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6UN15; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1553..1555
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     misc_feature    1715..1717
                     /gene="Fip1l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U317.1); phosphorylation site"
     exon            285..329
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..369
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..427
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..531
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..596
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..704
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..835
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..945
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1039
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1196
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1223
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1278
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1334
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1554
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1692
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..4569
                     /gene="Fip1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcatg cgcaggcgga ccagttgctg aatattcacg gtcgccgcct ccgccgaggt
       61 cgaccctgga tttgagtctc gcgctctctt cgttcgctta ccagcgggtt ccctcccctt
      121 ctcgcgccct gagacggcga ggctggggaa ggggttgaaa ggggctgttg atcgtcgcct
      181 ttaacttgtt cgaggggcgg ccatgtcggc cggcgaggtg gagcgtctgg tggagctgag
      241 cggcgggacc ggaggggatg aggaggaaga gtggctgtat ggcggcccgt gggacgtgca
      301 tgtgcacagt gatttggcaa aggatctaga tgaaaatgaa gttgaaaggc cagaagaaga
      361 aaatgccagt gctaatcctc cttctggaat tgaagaggaa gctgctgaaa atggcgtggc
      421 gaaaccgaaa gtgaccgaga ctgaagacga cagtgatagt gacagtgacg atgatgaaga
      481 tgacgttcac gttactattg gagacatcaa aacgggagct ccacagtatg ggagttatgg
      541 aacagcacca gtaaatctta atatcaaggc agggggaaga gtttatggaa atacaggaac
      601 caaagtcaaa ggagtagacc tcgatgcccc tggcagcatt aatggagttc cactcttgga
      661 agtagatttg gattcttttg aagataaacc atggcggaaa cctggtgctg atctttccga
      721 ttattttaat tatggcttta atgaagatac ttggaaagct tactgtgaaa aacaaaagag
      781 gatccgaatg ggactggaag ttatacccgt tacttcaacg acaaacaaga ttacggtaca
      841 gcaagggaga actggaaatt cagagaaaga agcagcactt ccatctacaa aagctgagtt
      901 tacttctccg ccatcattgt tcaagactgg tctgccacca agcaggagat tacctggagc
      961 aatcgatgtc attggtcaaa caataaccat cagccgagta gaaggaagac ggcgtgcaaa
     1021 tgagaacagc aatatacagg ttctttctga cagatctgcc actgaagtag acaacaattt
     1081 cagcaaacca cctccatttt tccctccagg ggctcctcct actcaccttc ctcctcctcc
     1141 atttcttcca cctcctccaa ctgtcagcac tgctccacct ttgattccac caccaggtat
     1201 tccaataact gtaccacctc caggtttccc ccctccacca ggcgctccac ctccatctct
     1261 tataccgaca atagaaagtg gccattcctc tggttacgac agccgttctg cacgggcgtt
     1321 tccatatggc aatgttgcct ttccccacct taccagttcc gctccctcat ggcctagcct
     1381 tgtggatacc actaagcagt gggactatta tgcacggaga gaaaaagatc gagatcgaga
     1441 ccgagagaga gaccgagaca gagaaaggga gagagaccgg gacagagaaa gggagcgcac
     1501 ccgggagcga gagcgggagc gggaccacag ccccacccca agtgttttca acagtgatga
     1561 agagcgatac agatacaggg agtatgcaga gagaggctat gagcgccaca gagctagtcg
     1621 ggagaaagaa gagcggcaca gagaacgacg gcacagagag aaggaggaaa caagacacaa
     1681 gtcctctcgc agtaatagta gacgtcgtca tgaaagtgaa gaaggggaca gtcacagaag
     1741 acacaagcac aaaaagtcta aaaggagcaa agaaggaaaa gaggctggca gcgagccggt
     1801 ccctgagcag gagagcacgg aagctgcccc tgccgagtag gcgccacctc ttatgtacgt
     1861 cagccccaga aatagatgct ataaatctcc ttatttttct ggataatgtt taagaaatgt
     1921 acctttaatc ttgttctgtt agaatgaaac gttaactttt tcttttccaa aataaaagtg
     1981 tgcatttttt tgtgttaagt taaaaatctt tgtcttgtaa tatttaaaga ataaaagaca
     2041 aaaattactt tatatctaag aaagtaatgt gaataagtca gcaggggact tagtgctaag
     2101 ttggccgtgt gtgcagtgtg gtgaggatca aggactcact agctttctag tgagcgggac
     2161 gctgtcggca ggagaggtgc tgtggtgcag aagcccctct catgtgacgt caggcttcct
     2221 cttactgctg tcacactcct gcatctttaa gaacttggac acattcttgt tatcacagtt
     2281 ttgatagcag gttttcagtg gtccatagta actaaatgga ctgtttgaat ctctgacttt
     2341 agagatggtc tgaggcactt gggtggccct atgatggaac ttgtgtgctt cccagcaggc
     2401 acatggactg gcacagcgtc aaaccacttc atggccatct gtttgaacaa gggtcaaggg
     2461 cttcagctgc tgctaacgtg ttttccaagg ctcattggta gcatagaacg tggggtattt
     2521 tttgtaatac caggtccata ttaataaaaa ataaactcag tgagagtagt gtcagatcag
     2581 tcattcttac taaaaccaga actccaggtt aaaatctgga ctaaccccaa gaaggttcca
     2641 gagcagcggt ggggctggga atgtgtgtga aaggacgagg cagttagagc caccagtaag
     2701 aggactgcgg tcacttagaa gaagatattc atctcttgtt caaatcctcc gccattaaac
     2761 tgaaatggcc ataatgtgct gtgtcttcaa ctccacttct accacatttg acgttgcctt
     2821 gaattaagtg tggcatacaa accatgtaag tttttatggg ctttttattg aattaaaaaa
     2881 atagaaactt aaaagatttg gagtgatgag aaatcctcca caccaaataa aaattaacat
     2941 tagtttttat ttttgagaac attctctgat gtgtaacttg ttttcataag tcatactttt
     3001 tctggctttt tttttttaca atatattctt taaatataaa aatcgacaag ataaatacaa
     3061 ttttatctag cctatttgtg gtttttctaa gatccatcat tggttttata aaaaagtacc
     3121 aggccaggaa gcaatggtga gagtaatttt ccctttgagt tctttgagca tcctcgctaa
     3181 gcaggcgtgc atcatccccg acgtgcttct gccgttgaca gcaagaagaa tgtcaccaca
     3241 tctgaaaaga tacggcattg tgatcagaac tgcttcaagc ctgaagcgcc tcaaagtgga
     3301 cttgggtggc cctagggctg ccatatttgt cctttttagt tctgatttga tttccctctt
     3361 cccataaatt ctccaagctc cacgcagcgt gcatcaaagg tataggaaat tgcaaggtgg
     3421 gaccaaggcc ggttctagtt ttggatttct ctctacctag ctagtgctct cgtgtcttaa
     3481 tttctcactc tttaggaaag tataagctgc gctttcttcc aagtggggcc aagttttaca
     3541 tgtagaaagc aaaatacttg aatattagtt ttctgagtaa tcattaccta attcttccat
     3601 cattatacgc gggtgttccc tcgacgatgg atttgataaa aaaaggttgg ttaccactgt
     3661 attcttcata acctcccaca atgcagaagc ccaggcttcc cgctgtgttc cttcgtagta
     3721 tcacatcctt acagttatat aagtacctga aacagaatgt aattagtgga tgtacagttg
     3781 agtttactag ttgtgactcc tttcattcat ttttttgggg gacactttta aaatgaaaaa
     3841 tactgcatat gtctccatca gaagtgacag caacttttta tgctcttagt cagcttttgc
     3901 atttgatctc tcttttccat agccaaatac cctttcaaca aaaggagtta gtattatgtt
     3961 ctattcatgt ctctgctgag aaaaatggcc acatattttg gttaaggcgc agtaatgaat
     4021 gcatgagcca aaagttggat gtgtctcagt acttcttatt ccccacagta gaacatactg
     4081 agggaatatc atttttatat tcttgggggc ttacataatt tgtaaagaag acaaacattc
     4141 tctgaattag cgattaatcg caaggacaat aattttaact tatgctaatg aacttatact
     4201 cacacagact tagagaagac tagagaaagt gaatggaaat tgggccataa aatagtggag
     4261 cagttgtcgg acagtaagtg gcatagctga agcagtcagg ggaagggaag gagcacagct
     4321 ggcctgagag ccagtacagc cttcagctgg gatagccgcg gctaagtgtg agcagctgca
     4381 ctacagtaga ctgtcggaag atggggtcgc tctgggaccc cttgtctgcc gcatgtgtct
     4441 aggaactgct tttgactgga agatagtatt ttttgttgtt agaattgaag atgtcttgtt
     4501 tatagactgt accttaaaat aatcagttgc tttttgataa tcaataaaaa tgatcttgtg
     4561 aaatattaa
//
LOCUS       NM_001437104            1507 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus ADP-ribosyltransferase 3 (Art3), transcript
            variant 2, mRNA.
ACCESSION   NM_001437104 XM_006250727
VERSION     NM_001437104.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Shi,W., Gong,P., Fan,J., Yan,Y.H., Ni,L., Wu,X., Cui,G., Wu,X.,
            Gu,X. and Chen,J.
  TITLE     The expression pattern of ADP-ribosyltransferase 3 in rat traumatic
            brain injury
  JOURNAL   J Mol Histol 43 (1), 37-47 (2012)
   PUBMED   22037978
  REMARK    GeneRIF: ART3 may play important roles in CNS pathophysiology after
            traumatic brain injury (TBI).
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Wang,B., Golemis,E.A. and Kruh,G.D.
  TITLE     ArgBP2, a multiple Src homology 3 domain-containing,
            Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed
            cells and localized in stress fibers and cardiocyte Z-disks
  JOURNAL   J Biol Chem 272 (28), 17542-17550 (1997)
   PUBMED   9211900
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_006250727.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223913.1, FQ224878.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000014.1  15949505-15949617   c
            114-191             JAXUCZ010000014.1  15948319-15948396   c
            192-900             JAXUCZ010000014.1  15943480-15944188   c
            901-933             JAXUCZ010000014.1  15933334-15933366   c
            934-966             JAXUCZ010000014.1  15931791-15931823   c
            967-996             JAXUCZ010000014.1  15930423-15930452   c
            997-1029            JAXUCZ010000014.1  15926899-15926931   c
            1030-1083           JAXUCZ010000014.1  15924735-15924788   c
            1084-1116           JAXUCZ010000014.1  15923643-15923675   c
            1117-1507           JAXUCZ010000014.1  15921540-15921930   c
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1507
                     /gene="Art3"
                     /note="ADP-ribosyltransferase 3"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
     exon            1..113
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            114..191
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1247
                     /gene="Art3"
                     /EC_number="2.4.2.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; ecto-ADP-ribosyltransferase 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform 1
                     precursor"
                     /protein_id="NP_001424033.1"
                     /db_xref="GeneID:305235"
                     /db_xref="RGD:628833"
                     /translation="MKMGHFELVTTLLAAMVLMDVFQVQAEVLDMAENVFDDEYLKCN
                     SRMEMKYIPRMHGEELANDELLQSVWDKAGIQWEAQKAQLSLPKNFKDAYGIALTAYV
                     TEAQDQSPFYHTFNRAVKIAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEESYKNV
                     VYSTSPNISFAFGEQNQARLGNFTLAYSAKPQTANEQRLLTIQTCFGVAVGKLLNKES
                     EGIVLIPLSEVFQVSRKGTDDDLILHSINSTCSYYECSFLGGLKAGSCTTNPENPDPG
                     YLNNPDLDSQKLEDSGRKSLDSVKMPEIKVLQGEENPLLPDEKPEDRNRGKANVPTPG
                     LVPVPGPKSHPSSSSGHRLLPSDTASTILLIAAAVDFIAL"
     sig_peptide     123..200
                     /gene="Art3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    207..875
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     misc_feature    207..875
                     /gene="Art3"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; Region: VIP2; cl00173"
                     /db_xref="CDD:469640"
     exon            192..900
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..933
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..966
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            967..996
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1029
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1083
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1116
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1507
                     /gene="Art3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctctcact gtcaacaaca tcctgtcctg gagggaagat caccccagct gagagtggga
       61 atcggtttga gtcggggcat catttaaacg tcctgcaaag gcacaaacgc cagaagagaa
      121 aaatgaagat gggacatttt gaattggtca ccacgctgct ggcagccatg gttctaatgg
      181 acgtcttcca ggtgcaggcg gaagtgttag acatggcaga gaatgtgttt gacgacgaat
      241 atttgaagtg caatagcaga atggaaatga agtatatccc tcggatgcac ggtgaggagt
      301 tggcaaatga cgagctcctg cagagtgtgt gggacaaggc agggatccag tgggaggcgc
      361 agaaggctca gctctccctc cctaagaact tcaaggatgc ctatggaata gctctgacag
      421 cttacgtaac cgaggctcag gaccagagtc ccttttacca cacattcaac cgtgctgtga
      481 agatagccgg cctgtcccga agacgctaca tctataactt tccgttcaaa gcgtttcatt
      541 tttacctggt aagagccctg cagctgctga gacgaccttg tgaggagagt tacaaaaacg
      601 tggtgtacag cacgagcccc aacatttcat tcgctttcgg cgagcaaaac caagccaggc
      661 tgggcaactt cacgttggcg tattcagcca aaccccagac agctaacgag caacggctgc
      721 taaccatcca gacctgcttt ggagttgccg tgggaaagct tcttaataaa gaaagtgagg
      781 gaattgttct aatccctctg agtgaggttt ttcaggtgtc aaggaaagga actgacgacg
      841 acctcatcct tcacagcata aacagtacct gcagctacta cgagtgttca ttcctcgggg
      901 gtctaaaagc tggtagttgt accacaaacc cagaaaatcc tgaccctgga tatctcaaca
      961 accctgatct ggacagtcag aagctcgaag actctggtag gaaaagcctt gactctgtga
     1021 aaatgccaga aattaaagtg ctacaaggag aggaaaatcc cctcctgcca gatgaaaagc
     1081 ctgaagacag aaatcgagga aaggccaacg ttcctactcc aggtctggtt ccggttccag
     1141 gtccgaagtc ccatccttcg tcatcctctg gccatcggct ccttccgtca gacacagcat
     1201 ccaccatttt actcatcgct gctgctgtgg acttcatcgc tctatagctt ggaacgctac
     1261 cttattctct atctgaaaga tgctacgggg atcccacagg aggtccagag aaaaaaatag
     1321 ttttcctttg gacagactca ctgtgtaaaa gaagaactgt atatttgtgc cttgttctgc
     1381 aagttaaaaa gctggtccag acagtgtcat agaattaact tttcatttct gtattaattt
     1441 taggactgca aaaatcccaa agctgtatac ttagattgga ttcaataaaa agtttaagtt
     1501 tactaaa
//
LOCUS       NM_001437208            3357 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus kelch-like family member 8 (Klhl8), transcript
            variant 2, mRNA.
ACCESSION   NM_001437208 XM_008770005
VERSION     NM_001437208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Nam,S., Min,K., Hwang,H., Lee,H.O., Lee,J.H., Yoon,J., Lee,H.,
            Park,S. and Lee,J.
  TITLE     Control of rapsyn stability by the CUL-3-containing E3 ligase
            complex
  JOURNAL   J Biol Chem 284 (12), 8195-8206 (2009)
   PUBMED   19158078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2025 this sequence version replaced XM_008770005.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.53831.1,
                                           SRR26360190.2770607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000014.1  6112497-6112683
            188-299             JAXUCZ010000014.1  6114582-6114693
            300-360             JAXUCZ010000014.1  6129491-6129551
            361-728             JAXUCZ010000014.1  6133127-6133494
            729-1277            JAXUCZ010000014.1  6143478-6144026
            1278-1464           JAXUCZ010000014.1  6145448-6145634
            1465-1608           JAXUCZ010000014.1  6147858-6148001
            1609-1720           JAXUCZ010000014.1  6149478-6149589
            1721-1889           JAXUCZ010000014.1  6152615-6152783
            1890-2049           JAXUCZ010000014.1  6152981-6153140
            2050-2251           JAXUCZ010000014.1  6155779-6155980
            2252-3357           JAXUCZ010000014.1  6156877-6157982
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3357
                     /gene="Klhl8"
                     /note="kelch-like family member 8"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
     exon            1..187
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            188..299
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            300..360
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            361..728
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    399..401
                     /gene="Klhl8"
                     /note="upstream in-frame stop codon"
     CDS             510..2375
                     /gene="Klhl8"
                     /note="kelch-like 8"
                     /codon_start=1
                     /product="kelch-like protein 8"
                     /protein_id="NP_001424137.1"
                     /db_xref="GeneID:289457"
                     /db_xref="RGD:1304685"
                     /translation="MASESTNGKLARSHVTKGRRQQQQQQQVRSRSSVSECDGDDSFI
                     FEANEAWKDFHGSLLGFYENGELCDVTLKVGSKLISCHKLALACVIPYFRAMFLSEMS
                     EAKQALIEIRDFDGDAVEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY
                     MKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLL
                     SSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPVDFLMGVVAKEQI
                     VKQNLKCRDLLDEARNYHLHLSSKPVPDFEYSVRTTPRKHTAGVLFCVGGRGGSGDPF
                     RSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTN
                     KWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMNTP
                     RGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHG
                     CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN
                     AYLNTVEAFDPVLNKWELVGPVSHCRAGAGVAVCDCLTSQIRDVGHGSTNVVDCM"
     misc_feature    666..1025
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    666..1025
                     /gene="Klhl8"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 8 (KLHL8); Region: BTB_POZ_KLHL8; cd18238"
                     /db_xref="CDD:349547"
     misc_feature    690..2117
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    690..2117
                     /gene="Klhl8"
                     /note="kelch-like protein; Provisional; Region: PHA03098"
                     /db_xref="CDD:222983"
     misc_feature    1578..1709
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1578..1709
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1719..1853
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1719..1853
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1860..1997
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1860..1997
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2001..2138
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2001..2138
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2142..2270
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2142..2270
                     /gene="Klhl8"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2175..2312
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     misc_feature    2175..2312
                     /gene="Klhl8"
                     /note="Kelch domain; Region: Kelch; smart00612"
                     /db_xref="CDD:128874"
     exon            729..1277
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1464
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1608
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1720
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1889
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2049
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2251
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..3357
                     /gene="Klhl8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccggg cacgagcaag cgggcgggca agtgagcgcg tccgccgagt gtcggagctg
       61 ggctggcgcg gcgccggcac ggagcgggtg tggcggctcg gcctgcgcgg cggccgcgga
      121 cagaggtaac cgctgcgtcg tccggcgcac gggactcagc ctggagcggc cacccgcgtt
      181 cgcgtcgtgc tggagatcaa attcagttga ctatttaaaa tacaccaatt actgtttact
      241 gcttctgcgg ccaacatctc gtgtgtggtc ggtcagcctg tttgctctgc tctgaggaga
      301 agctgcttaa cttcagacaa cctctgtggt cggttcctgg gatccttttc tgactttcca
      361 caaactgtct aatgaaattg aaggtttcga aagatgtcta aagcttagtg gccacatcta
      421 tcgtctgtct tctgaccctt aaaaaaaaaa aaacaaagaa taaatgggat gtttcagaag
      481 agagctattt aaaaggaaga gtgttgcaaa tggcttcaga atctaccaat gggaagctag
      541 ctaggagtca cgtgacaaag gggcggcgtc agcagcagca gcagcagcag gtgaggagcc
      601 ggtcctctgt cagcgagtgc gatggcgacg actccttcat cttcgaagcc aacgaggcct
      661 ggaaggactt tcacggctct ctcctgggct tctatgagaa cggggagctc tgtgacgtca
      721 ctctaaaggt cggctcgaag ctcatctcct gccacaagct ggcgctggct tgtgtcatcc
      781 cctacttcag agccatgttt ctttctgaaa tgtctgaggc taagcaggcg ctgatcgaga
      841 ttcgggactt tgacggcgat gccgtggagg acttggtgaa gttcgtctac tcttcgcggc
      901 tcactctgac agtggacaac gtccagcctc tgctgtatgc agcgtgcatc ctgcaggttg
      961 aactggtggc cagagcttgc tgcgaataca tgaagctaca ctttcatccc tccaactgcc
     1021 tggctgtgcg agcctttgcg gagagtcaca accgaacaga cctaatggac atggcggacc
     1081 agtatgcgtg cgagcacttt actgaagtgg tagagtgtga ggacttcgtg agcgtgtccc
     1141 cacagcacct gcacaagctc ctctcctcca gcgacctcaa catcgacagc gagaagcagg
     1201 tctacagtgc cgccatcaag tggcttcttg ccaacccaca gcatcaccct aaatggctgg
     1261 acgagaccct tgcccaggtc cgtctgccac tcttgccagt ggatttcctc atgggcgttg
     1321 tggcaaaaga gcagattgtc aagcaaaatc tgaaatgtag agacctactg gatgaagcca
     1381 gaaattacca ccttcatttg agcagtaaac cagttcctga ctttgagtat tcagtccgaa
     1441 ctaccccgag gaagcatact gctggtgtgc tgttctgtgt gggtggtcga ggtggatctg
     1501 gtgacccctt tcgtagtatc gaatgctatt ctatcaacac aaacagctgg ttctttggac
     1561 cagaaatgaa cagccgcagg aggcatgtgg gcgtgatctc tgtggaaggg aaagtgtatg
     1621 ccgtgggcgg ccatgatggg aacgagcacc taggcagcat ggagatgttt gaccctctca
     1681 ctaacaaatg gatggtgaag gcatcgatga acaccaagag gcgaggaatt gccttggcct
     1741 ccttaggggg cccaatatat gcgattggag gattagatga caacacttgc ttcagtgacg
     1801 tggagagata cgacattgaa tctgaccagt ggagtacggt ggcgccaatg aacactcccc
     1861 gtggaggtgt cggctctgtg gctttaatca accatgttta cgcagtgggt ggcaacgatg
     1921 gcgtagcctc cttgtccagt gtggaaaggt atcacccgca tctggataag tgggtggagg
     1981 tgaaggagat gggccagcgg agagccggca atggtgttag tgagcttcac ggctgcttat
     2041 acgttgttgg tggttttgat gataattccc ctctgagttc ggttgagcgg tacgatcctc
     2101 ggagcaacaa gtgggactat gtggcagcgc tcaccactcc caggggtggc gtagggattg
     2161 cgacggtgat gggcaagatc tttgcagtcg gaggccacaa cggcaatgcc tacctcaaca
     2221 cagtggaggc gttcgaccct gtgctgaata aatgggaact ggtcggacct gtgtctcact
     2281 gccgagctgg tgccggtgtg gccgtgtgtg actgcttaac tagccagatc cgagacgtag
     2341 gtcatgggtc cactaacgtg gttgactgta tgtgattaag tcccagcaac aaggatacag
     2401 tgccatctga tggacgggaa gacgagcctt tcaacatggc gcatttgatt gtgaccacag
     2461 ctactgtctt tgagtgtcag ctgttgtaag taggtctgtg ggctgacggt gagagctgct
     2521 agtcacagag tgaagtgagc tgtttcctgc ctcagcagac agtgagtagg ctggaagcag
     2581 cctgtcagcc cattcttgcg ctgagagacg tttcatgtag tgccaaacct taaaatagct
     2641 gtttattttg atgaataaaa tgtaatttat tgagttttat ctgttctttt tcctgaagaa
     2701 actaacttca ggcagtagat ttttttccca gaggagagag aagtccactc atcaacatga
     2761 gaacttgagg cctgctccct tgaggatcac tctacatggt gctggtgaat gtatgtcttg
     2821 ctttttgtct ccagatggtg actttcagtt cttgggtgtt tatgaagtag ggaaaatgtt
     2881 tgtgtgtttc tgagacattc ttgaaaccac attagtgtct gtaagaaggc cttggcctcc
     2941 atgtggagtt ttagaaccac aggacatagc tgtgcctgct tcctcaccaa gtgtactggc
     3001 cgccattctt ttcccattcg tgagagtttc ttggtgatga ccgtggcttg gcatgagtgc
     3061 agcgtccagt gaaaagactg agaaggatgt atgaagccca tgcccaccta gggaggttgt
     3121 ggaggctcct ttaaccttgt tcttctgctt agtcgttgaa tttggaacca ggacccattt
     3181 tctcttactc tgtcatttgt cgccgtcttg ggtttcctaa ttgtacaaag ctgaatttat
     3241 ttattatcag gacatgaatg cgtttttaca acattccttt ctgcagtata gtctgatgat
     3301 tagttccagt ttgtcattaa tcaataaaat atgttgctgg taaaaacaga aaaaaaa
//
LOCUS       NM_031680               1294 bp    mRNA    linear   ROD 31-MAR-2025
DEFINITION  Rattus norvegicus pyrimidinergic receptor P2Y4 (P2ry4), mRNA.
ACCESSION   NM_031680
VERSION     NM_031680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Dosh,R.H., Khalfa,H.M., Al-Rehemi,S.M., Almsaid,H.L. and Hadi,N.
  TITLE     IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT
            EPIDERMAL TISSUE
  JOURNAL   Wiad Lek 75 (11 pt 2), 2729-2733 (2022)
   PUBMED   36591760
  REMARK    GeneRIF: IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP
            IN RAT EPIDERMAL TISSUE.
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Szrejder,M., Rachubik,P., Rogacka,D., Audzeyenka,I., Rychlowski,M.,
            Angielski,S. and Piwkowska,A.
  TITLE     Extracellular ATP modulates podocyte function through P2Y
            purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA
            signaling pathways
  JOURNAL   Arch Biochem Biophys 695, 108649 (2020)
   PUBMED   33122160
  REMARK    GeneRIF: Extracellular ATP modulates podocyte function through P2Y
            purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA
            signaling pathways.
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Gohar,E.Y., Kasztan,M., Becker,B.K., Speed,J.S. and Pollock,D.M.
  TITLE     Ovariectomy uncovers purinergic receptor activation of
            endothelin-dependent natriuresis
  JOURNAL   Am J Physiol Renal Physiol 313 (2), F361-F369 (2017)
   PUBMED   28468962
  REMARK    GeneRIF: Activation of renal medullary P2Y2/P2Y4 receptors promotes
            ET-1-dependent natriuresis in ovariectomized rats.
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Anikina,T.A., Anisimova,I.N., Zverev,A.A., Sitdikov,F.G. and
            Zefirov,T.L.
  TITLE     Involvement of P2Y(2,4) receptors in the regulation of myocardial
            contractility in growing rats
  JOURNAL   Bull Exp Biol Med 156 (3), 299-302 (2014)
   PUBMED   24771361
  REMARK    GeneRIF: in 100-day-old animals, the myocardial inotropic response
            to the administration of uridine triphosphate was mediated by R2Y2
            receptors. R2Y4 receptors took part in the realization of negative
            inotropic response to uridine triphosphate in all age groups
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Traves,P.G., Pimentel-Santillana,M., Carrasquero,L.M.,
            Perez-Sen,R., Delicado,E.G., Luque,A., Izquierdo,M.,
            Martin-Sanz,P., Miras-Portugal,M.T. and Bosca,L.
  TITLE     Selective impairment of P2Y signaling by prostaglandin E2 in
            macrophages: implications for Ca2+-dependent responses
  JOURNAL   J Immunol 190 (8), 4226-4235 (2013)
   PUBMED   23479225
REFERENCE   6  (bases 1 to 1294)
  AUTHORS   Dranoff,J.A., Masyuk,A.I., Kruglov,E.A., LaRusso,N.F. and
            Nathanson,M.H.
  TITLE     Polarized expression and function of P2Y ATP receptors in rat bile
            duct epithelia
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (4), G1059-G1067 (2001)
   PUBMED   11557527
REFERENCE   7  (bases 1 to 1294)
  AUTHORS   Lazarowski,E.R., Rochelle,L.G., O'Neal,W.K., Ribeiro,C.M.,
            Grubb,B.R., Zhang,V., Harden,T.K. and Boucher,R.C.
  TITLE     Cloning and functional characterization of two murine uridine
            nucleotide receptors reveal a potential target for correcting ion
            transport deficiency in cystic fibrosis gallbladder
  JOURNAL   J Pharmacol Exp Ther 297 (1), 43-49 (2001)
   PUBMED   11259526
REFERENCE   8  (bases 1 to 1294)
  AUTHORS   Suarez-Huerta,N., Pouillon,V., Boeynaems,J. and Robaye,B.
  TITLE     Molecular cloning and characterization of the mouse P2Y4 nucleotide
            receptor
  JOURNAL   Eur J Pharmacol 416 (3), 197-202 (2001)
   PUBMED   11290369
REFERENCE   9  (bases 1 to 1294)
  AUTHORS   Webb,T.E., Henderson,D.J., Roberts,J.A. and Barnard,E.A.
  TITLE     Molecular cloning and characterization of the rat P2Y4 receptor
  JOURNAL   J Neurochem 71 (4), 1348-1357 (1998)
   PUBMED   9751165
REFERENCE   10 (bases 1 to 1294)
  AUTHORS   Bogdanov,Y.D., Wildman,S.S., Clements,M.P., King,B.F. and
            Burnstock,G.
  TITLE     Molecular cloning and characterization of rat P2Y4 nucleotide
            receptor
  JOURNAL   Br J Pharmacol 124 (3), 428-430 (1998)
   PUBMED   9647463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 24, 2025 this sequence version replaced NM_031680.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11433.1, SRR26643295.61063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000021.1  69728479-69728555   c
            78-1294             JAXUCZ010000021.1  69727025-69728241   c
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1294
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="pyrimidinergic receptor P2Y4"
                     /db_xref="GeneID:63843"
                     /db_xref="RGD:61798"
     exon            1..77
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    75..77
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="upstream in-frame stop codon"
     exon            78..1294
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1169
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="pyrimidinergic receptor P2Y, G-protein coupled, 4;
                     purinergic receptor P2Y, G-protein coupled 4; P2Y ATP
                     receptor 4"
                     /codon_start=1
                     /product="P2Y purinoceptor 4"
                     /protein_id="NP_113868.1"
                     /db_xref="GeneID:63843"
                     /db_xref="RGD:61798"
                     /translation="MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVL
                     GLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTG
                     LCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVA
                     GCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGL
                     MARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHV
                     LNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALV
                     TLHEESISRWADTHQDSTFSAYEGDRL"
     misc_feature    84..143
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    174..257
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    177..1022
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="P2Y purinoceptor 4, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_P2Y4; cd15374"
                     /db_xref="CDD:320496"
     misc_feature    177..1022
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="P2Y purinoceptor 4, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_P2Y4; cd15374"
                     /db_xref="CDD:320496"
     misc_feature    177..260
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320496"
     misc_feature    177..260
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320496"
     misc_feature    279..356
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320496"
     misc_feature    279..356
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320496"
     misc_feature    288..356
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    order(342..344,351..356,393..410,414..419,426..428,
                     561..563,567..581,621..623,627..635,660..662,669..677,
                     681..689,693..698,843..845,852..857,861..866,873..875,
                     921..926,930..938,945..947,954..959)
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320496"
     misc_feature    order(342..344,351..356,393..410,414..419,426..428,
                     561..563,567..581,621..623,627..635,660..662,669..677,
                     681..689,693..698,843..845,852..857,861..866,873..875,
                     921..926,930..938,945..947,954..959)
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320496"
     misc_feature    393..485
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320496"
     misc_feature    393..485
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320496"
     misc_feature    408..464
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    519..587
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320496"
     misc_feature    519..587
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320496"
     misc_feature    531..593
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    606..608
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35811.1); glycosylation site"
     misc_feature    660..749
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320496"
     misc_feature    660..749
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320496"
     misc_feature    660..737
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    783..875
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320496"
     misc_feature    783..875
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320496"
     misc_feature    810..878
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
     misc_feature    924..1001
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320496"
     misc_feature    924..1001
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320496"
     misc_feature    933..998
                     /gene="P2ry4"
                     /gene_synonym="P2Y4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35811.1);
                     transmembrane region"
ORIGIN      
        1 agaacatcat tgactgccta cctgagccca agctctgtct gatgccatca gtccctgggc
       61 tggactaagg aagctagggg gccatgacca gtgcagaatc cttgctattc acatcactag
      121 gtcccagccc aagttctgga gatggtgatt gtaggtttaa tgaggagttc aagttcatcc
      181 tgttgcctat gagctatgca gttgtgtttg tgctgggcct ggccctcaat gctccaaccc
      241 tctggctgtt cctcttccgc cttcgaccct gggatgcaac agccacctac atgttccacc
      301 tggcattgtc agacaccttg tatgtgctgt cactgcccac cctcgtctac tactatgctg
      361 ccagaaacca ctggcccttt ggcactggcc tttgcaagtt tgtccgcttt ctcttctatt
      421 ggaacctcta ctgtagtgtc cttttcctca cctgcatcag tgtgcaccga tacctgggta
      481 tctgccaccc actgcgggca atccgctggg gccgccctcg atttgcaagc cttctctgcc
      541 tgggtgtttg gttggtagta gctggctgcc tcgtgcccaa tcttttcttt gtgacaacca
      601 atgccaatgg aactaccatc ctgtgccatg acactactct gccagaggag tttgaccact
      661 acgtctactt cagttcggca gtcatggtgc tgctctttgg tttgcccttc ttgatcaccc
      721 tggtctgcta tggactcatg gcccggcgac tgtatcgacc tttgccagga gctggacagt
      781 catcttctcg gctccgttcc ctccgtacca ttgctgtggt gctgactgtc tttgctgtct
      841 gcttcgtgcc tttccacatc acccgcacaa tttattacca ggcaagactg ttgcaagctg
      901 actgtcatgt gctgaacatt gtcaatgtgg tttacaaggt gactcgaccc ctggccagtg
      961 ctaatagctg tcttgatcca gtgctctatc tcttcacggg ggacaagtat cgaaaccagc
     1021 tccagcagct atgccgaggc agcaaaccca agccccgaac agctgcctcc tccctggcct
     1081 tggtgactct acatgaggaa agcatcagca ggtgggcgga cacccaccaa gacagcacct
     1141 tctctgctta tgagggagat cgattgtaac cctgctgctg gatatgaagg gaactaactg
     1201 cagggcagag gggagggagc ttgttagtat cacttgacag gggcatcagc tgtcctcttt
     1261 tatagccgaa gtttgaagga gctactcctc tgcc
//
LOCUS       NM_001163519            1830 bp    mRNA    linear   ROD 11-SEP-2014
DEFINITION  Rattus norvegicus coiled-coil domain containing 166 (Ccdc166),
            transcript variant 2, mRNA.
ACCESSION   NM_001163519 NR_027960 XM_001074627
VERSION     NM_001163519.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD,
            Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg
            B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T,
            Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin
            GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL,
            Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P,
            Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy
            SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH,
            Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW,
            Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J,
            Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M,
            Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW,
            Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J,
            Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U,
            Smailus DE, Schnerch A, Schein JE, Jones SJ and Marra MA.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC160829.1.
            
            On or before Jul 24, 2009 this sequence version replaced
            XM_001074627.1, NR_027960.1.
            
            Transcript Variant: This variant (2) retains an intron resulting in
            a frameshift, compared to variant 1. The resulting isoform (2) has
            a shorter and distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC160829.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1830              BC160829.1         1-1830
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1830
                     /gene="Ccdc166"
                     /note="coiled-coil domain containing 166"
                     /db_xref="GeneID:680799"
                     /db_xref="RGD:1588167"
     misc_feature    164..166
                     /gene="Ccdc166"
                     /note="upstream in-frame stop codon"
     CDS             227..811
                     /gene="Ccdc166"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 166"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 166
                     isoform 2"
                     /protein_id="NP_001156991.1"
                     /db_xref="GeneID:680799"
                     /db_xref="RGD:1588167"
                     /translation="MAPKKKRGQNAGRKQAGQSGEPQLSERGQYLQREYAMLSESLAV
                     CEQRIDEVLQSNAFLNSEAQRLKEENRLFVGYVSAHALRCANAIVRLEDQNRTDLAQI
                     RWQRAELASFYHGREDGVRAQLQEMKKRAENMTQQVQELQPYKASARAPADRAGSRGV
                     GTLPTGALIGTHRPTSPHVGVAAGAAGTNPDPGA"
     misc_feature    431..>661
                     /gene="Ccdc166"
                     /note="Domain of unknown function (DUF4515); Region:
                     DUF4515; pfam14988"
                     /db_xref="CDD:405647"
     misc_feature    431..>661
                     /gene="Ccdc166"
                     /note="Domain of unknown function (DUF4515); Region:
                     DUF4515; pfam14988"
                     /db_xref="CDD:405647"
ORIGIN      
        1 caggatgcga aagccgtggt ccagagggag tgctcatata cagattggct acggtgctct
       61 ctgatcctta atcccgcctg ctctgaacct cataaactga agacacatcc ctgaacctag
      121 ggtgtggttc ttcagaattt ttgggttaag gagggggagt aactgagctg ggggagcggg
      181 tggagcacgg tgttctcatg agtccagttg gcctgggtct caagccatgg cgcccaagaa
      241 gaagcgcgga caaaacgctg ggcgcaagca ggcgggccaa agtggggagc cacagctctc
      301 ggagcgcggg cagtacttac agcgcgagta tgcgatgctc tcggagagcc tggcggtctg
      361 tgagcagcgg atagacgagg tgctgcagag caatgcgttc ctgaacagcg aggcgcagcg
      421 cttaaaggaa gaaaaccggc tttttgtcgg ttatgtgagc gcgcacgctc tgcgctgcgc
      481 caacgccatc gtgcgcctcg aggaccagaa ccgcacagac ctggcgcaga tccggtggca
      541 gcgagcggag ctggcgtcgt tttaccacgg ccgcgaggac ggggtgcgtg cacagctgca
      601 ggaaatgaag aagcgcgcag aaaacatgac acagcaggtg caggagctgc agccctacaa
      661 ggccagtgcg cgcgcccccg cggaccgggc agggtcgaga ggggtgggca cgctccctac
      721 cggtgctctg atcggcaccc accgccccac ctcaccccat gtaggagttg cagctggagc
      781 agctggcacg aatccggacc ctggagcgtg agctgctgca tatgcgcgtg gagcacacgc
      841 agctcctcca ccaggtgaag caacgcttcc tggatgataa gtctgctttc gagcgggagg
      901 cacgcctgca cgtgcagtcc ctgacacgtc gcgcagagcg ggaggcagcg ctttccctta
      961 tttcccacgc acaggccctc aaggcagaca atgggcgtct ccgacaagaa ctcatgaggc
     1021 ttctccagag ggcccagtta ctgcagaaca tgcgccagca gctgctggag cagcgggagc
     1081 agctgcgccg ggagcacgtg gacatgcaga acctggagca catgcacggc tggttgcaca
     1141 ggggtcccgg agggccacca ctctggcagc caccccaaag ccaccaacct aacttgcgca
     1201 tcgggtcatt tgtcaccgcg ctggactcaa cacaacacat gttaagagcc caggctgcac
     1261 cccaatcatt ttcgtcctcc cgggttccat cggtggatca gtcgcaccga gcctccagga
     1321 gtccatccgt actgtccagt gagtctttcc cgggccggtc tcttaaggct gggtctgtga
     1381 ttgctccccg gagttcatcc ggtctaagat ctcgagtctc atctctgact ccatcacgca
     1441 ggggctcgcg gatctcatcc gtgaccccgt cacgcaaggg ctccacagtt ccatccatga
     1501 cctcaggtcc cttgcggcca cgggaggact ctcgactctc tccgcagccc tccttgcgtg
     1561 agatgtcttc agaaactgac acacctgcaa aatccagctc caagcttttt tcagggctgt
     1621 cggaagatca cttccctctc agcccacaat tggaagagac agaaaacact gtggacaaca
     1681 cacaaactgt cttggagcaa gcctgaacat acacgagggg gcaggccaat aggtcatgga
     1741 gtggggagac ataccttgga agatttcttg gtgcataaat atgttaataa aagtgtaaaa
     1801 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
LOCUS       NM_001009650            1014 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 5 (Taar5), mRNA.
ACCESSION   NM_001009650 XM_220099
VERSION     NM_001009650.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1014)
  AUTHORS   Li,Q., Korzan,W.J., Ferrero,D.M., Chang,R.B., Roy,D.S., Buchi,M.,
            Lemon,J.K., Kaur,A.W., Stowers,L., Fendt,M. and Liberles,S.D.
  TITLE     Synchronous evolution of an odor biosynthesis pathway and
            behavioral response
  JOURNAL   Curr Biol 23 (1), 11-20 (2013)
   PUBMED   23177478
REFERENCE   2  (bases 1 to 1014)
  AUTHORS   Wallrabenstein,I., Kuklan,J., Weber,L., Zborala,S., Werner,M.,
            Altmuller,J., Becker,C., Schmidt,A., Hatt,H., Hummel,T. and
            Gisselmann,G.
  TITLE     Human trace amine-associated receptor TAAR5 can be activated by
            trimethylamine
  JOURNAL   PLoS One 8 (2), e54950 (2013)
   PUBMED   23393561
REFERENCE   3  (bases 1 to 1014)
  AUTHORS   Ferrero,D.M., Wacker,D., Roque,M.A., Baldwin,M.W., Stevens,R.C. and
            Liberles,S.D.
  TITLE     Agonists for 13 trace amine-associated receptors provide insight
            into the molecular basis of odor selectivity
  JOURNAL   ACS Chem Biol 7 (7), 1184-1189 (2012)
   PUBMED   22545963
REFERENCE   4  (bases 1 to 1014)
  AUTHORS   Staubert,C., Boselt,I., Bohnekamp,J., Rompler,H., Enard,W. and
            Schoneberg,T.
  TITLE     Structural and functional evolution of the trace amine-associated
            receptors TAAR3, TAAR4 and TAAR5 in primates
  JOURNAL   PLoS One 5 (6), e11133 (2010)
   PUBMED   20559446
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1014)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
REFERENCE   6  (bases 1 to 1014)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702318.1.
            
            On Jan 13, 2005 this sequence version replaced XM_220099.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1014
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="trace amine-associated receptor 5"
                     /db_xref="GeneID:294123"
                     /db_xref="RGD:1359185"
     CDS             1..1014
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /codon_start=1
                     /product="trace amine-associated receptor 5"
                     /protein_id="NP_001009650.1"
                     /db_xref="GeneID:294123"
                     /db_xref="RGD:1359185"
                     /translation="MRAVLLPGSGEQPAAFCYQVNGSCPRTVHPLAIRVLIYLACAVG
                     MLITVLGNLFVVFAVSYFKVLHTPTNFLLLSLALADMLLGLLVLPLSTVRSVESCWFF
                     GDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRIALRYIAAGWG
                     IPAAYTAFFLYTDVVERALSQWLEEMPCVGSCQLLFNKFWGWLNFPAFFIPCLIMISL
                     YLKIFVVATRQAQQIRTLSQSLSGAVKRERKAAKTLGIAVGIYLVCWLPFTVDTLVDS
                     LLNFVTPPLVFDIFIWFAYFNSACNPIIYVFSYRWFRKALKLLLSREILSPRTQTADL
                     FHD"
     misc_feature    61..63
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD23.1); glycosylation site"
     misc_feature    103..948
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    103..948
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    109..183
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320441"
     misc_feature    109..183
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320441"
     misc_feature    115..177
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    208..276
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320441"
     misc_feature    208..276
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320441"
     misc_feature    211..273
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    322..390
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320441"
     misc_feature    322..390
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320441"
     misc_feature    328..390
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    457..507
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320441"
     misc_feature    457..507
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320441"
     misc_feature    463..525
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    526..567
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     Region: Extracellular Loop 2 (ECL2).
                     /evidence=ECO:0000250|UniProtKB:Q5QD04"
     misc_feature    589..660
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320441"
     misc_feature    589..660
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320441"
     misc_feature    613..675
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    751..819
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320441"
     misc_feature    751..819
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320441"
     misc_feature    760..822
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     misc_feature    850..927
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320441"
     misc_feature    850..927
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320441"
     misc_feature    853..921
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD23.1);
                     transmembrane region"
     exon            1..1014
                     /gene="Taar5"
                     /gene_synonym="taR-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagagctg tcctcctccc cggctctgga gagcagcctg cggcgttctg ttaccaggtg
       61 aatgggtctt gccccaggac agtccacccg ctggccatcc gggtcctcat ctacctggcc
      121 tgcgcagtag gtatgctgat cacagtcctg gggaatttgt ttgtggtgtt tgccgtgtcc
      181 tactttaaag tgctccacac ccccaccaac ttcctgctgc tctccctggc tctggcggac
      241 atgttgctgg gtctgctggt gctgcccctg agcacagtcc gctctgtgga gagctgctgg
      301 ttcttcggag acttcctgtg ccgtctgcat acctacctgg acacgctgtt ctgccttacc
      361 tccatcttcc atctctgttt tatttccatt gaccgtcatt gtgccatctg tgaccccctg
      421 ctctatccct ccaagttcac agtcaggata gccctccgat acatagcggc agggtggggg
      481 ataccagcag cctacactgc cttctttctc tacacagatg tggtagagag agcactcagc
      541 cagtggctgg aagaaatgcc ttgtgtgggc agctgccagc tactgttcaa taagttctgg
      601 gggtggttaa acttccctgc gtttttcatc ccctgtctca tcatgatcag cttgtacctg
      661 aagatctttg tggtcgctac caggcaagct cagcagatca gaaccctgag ccaaagtttg
      721 tccggggctg tcaagcggga aagaaaagct gccaagacgc tgggcattgc tgtgggcatc
      781 taccttgtgt gttggcttcc cttcactgtg gacacgctgg tggacagcct ccttaacttc
      841 gtcaccccac ccctggtctt tgacatcttt atctggtttg cttatttcaa ttcagcctgt
      901 aaccccatca tctatgtctt ctcgtataga tggtttagga aggccctgaa actcctcctg
      961 agccgggaga tcctctcacc acggacacag actgctgatc tgttccatga ctga
//
LOCUS       NM_030840               2235 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 26 member 5 (Slc26a5),
            mRNA.
ACCESSION   NM_030840
VERSION     NM_030840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Costanzi,E., Coletti,A., Zambelli,B., Macchiarulo,A., Bellanda,M.
            and Battistutta,R.
  TITLE     Calmodulin binds to the STAS domain of SLC26A5 prestin with a
            calcium-dependent, one-lobe, binding mode
  JOURNAL   J Struct Biol 213 (2), 107714 (2021)
   PUBMED   33667636
  REMARK    GeneRIF: Calmodulin binds to the STAS domain of SLC26A5 prestin
            with a calcium-dependent, one-lobe, binding mode.
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Parham,K., Sohal,M., Petremann,M., Romanet,C., Broussy,A., Tran Van
            Ba,C. and Dyhrfjeld-Johnsen,J.
  TITLE     Noise-induced trauma produces a temporal pattern of change in blood
            levels of the outer hair cell biomarker prestin
  JOURNAL   Hear Res 371, 98-104 (2019)
   PUBMED   30529910
  REMARK    GeneRIF: These results suggest that there is a temporal pattern of
            change in serum prestin level after noise-induced hearing loss that
            is related to severity of hearing loss. Circulatory levels of
            prestin may be able to act as surrogate biomarker for hearing loss
            involving outer hair cell loss.
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Parham,K. and Dyhrfjeld-Johnsen,J.
  TITLE     Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker
            for Hearing Loss: Proof of Concept
  JOURNAL   Otol Neurotol 37 (9), 1217-1222 (2016)
   PUBMED   27636386
  REMARK    GeneRIF: work, for the first time, provides proof of concept that
            the levels of prestin, an otologic serum biomarker, can change
            after acoustic trauma and hearing loss
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Lolli,G., Pasqualetto,E., Costanzi,E., Bonetto,G. and
            Battistutta,R.
  TITLE     The STAS domain of mammalian SLC26A5 prestin harbours an
            anion-binding site
  JOURNAL   Biochem J 473 (4), 365-370 (2016)
   PUBMED   26635354
  REMARK    GeneRIF: in chicken STAS, the anion-binding site is lacking because
            of a local structural rearrangement, indicating that the presence
            of the STAS anion-binding site is exclusive to mammalian prestin
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Hang,J., Pan,W., Chang,A., Li,S., Li,C., Fu,M. and Tang,J.
  TITLE     Synchronized Progression of Prestin Expression and Auditory
            Brainstem Response during Postnatal Development in Rats
  JOURNAL   Neural Plast 2016, 4545826 (2016)
   PUBMED   28097024
  REMARK    GeneRIF: Prestin expression first appeared at postnatal day 6 (P6)
            in the auditory brainstem and reached mature level by P14.
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Weber,T., Zimmermann,U., Winter,H., Mack,A., Kopschall,I.,
            Rohbock,K., Zenner,H.P. and Knipper,M.
  TITLE     Thyroid hormone is a critical determinant for the regulation of the
            cochlear motor protein prestin
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2901-2906 (2002)
   PUBMED   11867734
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 May 28;99(11):7809]
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Oliver,D., He,D.Z., Klocker,N., Ludwig,J., Schulte,U.,
            Waldegger,S., Ruppersberg,J.P., Dallos,P. and Fakler,B.
  TITLE     Intracellular anions as the voltage sensor of prestin, the outer
            hair cell motor protein
  JOURNAL   Science 292 (5525), 2340-2343 (2001)
   PUBMED   11423665
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Ludwig,J., Oliver,D., Frank,G., Klocker,N., Gummer,A.W. and
            Fakler,B.
  TITLE     Reciprocal electromechanical properties of rat prestin: the motor
            molecule from rat outer hair cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4178-4183 (2001)
   PUBMED   11274441
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Belyantseva,I.A., Adler,H.J., Curi,R., Frolenkov,G.I. and Kachar,B.
  TITLE     Expression and localization of prestin and the sugar transporter
            GLUT-5 during development of electromotility in cochlear outer hair
            cells
  JOURNAL   J Neurosci 20 (24), RC116 (2000)
   PUBMED   11125015
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Bostjancic,W., Braun,J.S., Reheis,G., Weisshaar,D., Akkerman,J.W.,
            Banauch,D. and Koller,P.U.
  TITLE     [Pre-stained slides for differential blood counts (author's
            transl)]
  JOURNAL   Dtsch Med Wochenschr 102 (33), 1175-1177 (1977)
   PUBMED   70328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ303372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ303372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="solute carrier family 26 member 5"
                     /db_xref="GeneID:83819"
                     /db_xref="RGD:69334"
     CDS             1..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="prestin (motor protein); solute carrier family 26
                     (anion exchanger), member 5"
                     /codon_start=1
                     /product="prestin"
                     /protein_id="NP_110467.1"
                     /db_xref="GeneID:83819"
                     /db_xref="RGD:69334"
                     /translation="MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGD
                     KLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFA
                     MLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPG
                     GVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAA
                     VHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGK
                     EFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTS
                     LFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFS
                     ISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKG
                     MFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSY
                     TVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAI
                     IMGARRKAMRKYAKEVGNANIANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTT
                     FPEELQRFLPQGENIHTVILDFTQVNFMDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQ
                     VVNDLTSNRFFENPALKELLFHSIHDAVLGSQVREAMAEQETTVLPPQEDMEPNATPT
                     TPEA"
     misc_feature    196..2127
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    196..2127
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="putative transporter; Provisional; Region:
                     PRK11660; cl46980"
                     /db_xref="CDD:481320"
     misc_feature    226..312
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    325..378
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    412..447
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    472..504
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     Region: Involved in motor function.
                     /evidence=ECO:0000250|UniProtKB:Q9JKQ2"
     misc_feature    487..489
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH0.1); glycosylation site"
     misc_feature    496..498
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH0.1); glycosylation site"
     misc_feature    505..588
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    619..690
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    775..828
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    874..921
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    997..1077
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1111..1164
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1189..1218
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1192..1194
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="Controls the electromotile activity.
                     /evidence=ECO:0000269|PubMed:24710176; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH0.1); other site"
     misc_feature    1195..1197
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="Contributes to anion binding.
                     /evidence=ECO:0000269|PubMed:24710176; propagated from
                     UniProtKB/Swiss-Prot (Q9EPH0.1); other site"
     misc_feature    1231..1293
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1309..1392
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1396..1443
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1453..1512
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     transmembrane region"
     misc_feature    1513..2154
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     Region: Extended region for STAS domain.
                     /evidence=ECO:0000269|PubMed:20471983,
                     ECO:0007744|PDB:3LLO"
     misc_feature    2158..2232
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPH0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..152
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            153..292
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            293..403
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            404..570
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            571..735
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            736..888
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            889..971
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1119
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1233
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1311
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1407
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1514
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1584
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1677
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1785
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1986
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2041
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2235
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatcatg ctgaagaaaa tgaaattcct gcagagactc agaagtacct cgtggaaagg
       61 cctatcttca gtcatccggt cctccaggag aggctgcacg tcaaggacaa agtcacagac
      121 tccatcgggg ataagctgaa gcaggcattc acgtgcactc ctaaaaaagt aagaaacatc
      181 atctacatgt tcttgcccat cactaagtgg ttgccagcat ataaattcaa ggagtatgtg
      241 ctgggtgact tggtctcggg cataagcact ggggtgcttc agctccccca aggcttagcc
      301 ttcgcgatgc tggcagctgt gcctccggtg ttcggcctgt actcctcatt ttaccccgtt
      361 atcatgtact gtttctttgg aacctccaga cacatatcta taggtccttt tgcggttatt
      421 agcttgatga ttggaggtgt ggctgtccgc ttggtaccgg atgacatcgt tatcccagga
      481 ggagtaaatg caaccaatgg gacggaagcc agagatgcgt taagggtcaa agtcgccatg
      541 tccgttaccc tactttcagg aatcattcag ttttgcctag gtgtctgtag gtttggattt
      601 gtggccatat acctcacgga gccgctagtg cgaggcttta ccacggcggc ggctgtgcac
      661 gtgttcacct ccatgttaaa atacctgttt ggggtcaaaa ctaagcggta cagtgggatc
      721 ttctcagtgg tgtatagtac cgtggctgtg ctgcagaatg ttaaaaacct caacgtgtgt
      781 tccctaggcg tcggcctcat ggtttttggt ttgctgttgg gtggcaagga gtttaatgag
      841 agatttaaag agaaactgcc agcgcccatt cctctagagt tctttgctgt ggtgatgggg
      901 accggcattt ctgcagggtt taacttgcac gagtcctaca gcgtggatgt cgttgggaca
      961 cttcctctgg gactactccc acccgccaac ccggacacca gcctgttcca cctcgtgtac
     1021 gtggacgcca ttgccatcgc cattgttggg ttttcagtga cgatctccat ggccaaaacc
     1081 ttggcaaata agcatggcta ccaggttgat ggcaaccagg agctcattgc cttgggaata
     1141 tgcaactcca tcggatctct cttccagacc ttctcaatct cttgctcctt gtctcgaagc
     1201 cttgttcagg aaggaactgg agggaagaca cagcttgcag gttgcttggc ctcactgatg
     1261 atcctgctgg tcatattagc cactggattc ctctttgagt cattacccca ggccgtgctt
     1321 tccgccattg tgattgtcaa cctgaaagga atgttcatgc agttctcaga cctgcccttt
     1381 ttctggagaa ccagcaaaat cgagttgacc atctggctca ccacctttgt gtcctccctg
     1441 ttcctgggct tggactatgg actgattact gctgtgatca ttgctctgct cactgtgatt
     1501 tacagaacac agagtccgag ctacacagtc ctgggacagc tccctgacac cgatgtatac
     1561 attgacattg atgcctatga ggaggtgaaa gaaattcctg gaataaaaat attccaaata
     1621 aatgccccaa tttactatgc aaatagcgac ttgtacagca gcgcactgaa aagaaagact
     1681 ggcgtgaacc cagcaatcat catgggagca agaagaaagg ccatgaggaa gtacgcgaag
     1741 gaggttggaa atgccaacat agctaacgcg actgttgtca aagtggatgc agaagtagat
     1801 ggagaaaatg ctacgaagcc tgaagaagag gacgacgaag tcaaatttcc cccaatagtc
     1861 atcaaaacaa catttcctga agagctgcag aggtttttgc cccaggggga aaatatccac
     1921 actgtcattc tagacttcac gcaggtcaat tttatggatt ctgttggagt gaaaactctg
     1981 gctgggattg tgaaagagta cggcgatgtt ggaatttatg tgtacttagc aggatgcagt
     2041 gcacaagttg tgaatgacct caccagcaac cgtttttttg aaaatcctgc cttaaaggag
     2101 cttctgttcc acagtatcca tgacgcggtc ttgggcagcc aagtccgtga ggcgatggct
     2161 gagcaagaaa ccacggttct gcctccccag gaagatatgg agcccaatgc cacgcccacc
     2221 acaccggaag cataa
//
LOCUS       NM_001014779            2340 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus protocadherin beta 8 (Pcdhb8), mRNA.
ACCESSION   NM_001014779 XM_226000
VERSION     NM_001014779.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2340)
  AUTHORS   Wu,Q.
  TITLE     Comparative genomics and diversifying selection of the clustered
            vertebrate protocadherin genes
  JOURNAL   Genetics 169 (4), 2179-2188 (2005)
   PUBMED   15744052
REFERENCE   2  (bases 1 to 2340)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On Apr 8, 2005 this sequence version replaced XM_226000.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2340
                     /gene="Pcdhb8"
                     /note="protocadherin beta 8"
                     /db_xref="GeneID:680020"
                     /db_xref="RGD:1309895"
     CDS             1..2340
                     /gene="Pcdhb8"
                     /codon_start=1
                     /product="protocadherin beta 8"
                     /protein_id="NP_001014779.1"
                     /db_xref="GeneID:680020"
                     /db_xref="RGD:1309895"
                     /translation="METALAKTPEKRQVIFLAILLLLWESGSEAIRYSMPEETESGYL
                     IANLAKDLGLQIGELSTRGARIHHNGNKELLQLDAKRGNLLLKEKPDREALCGATEPC
                     VLHFQIILENPVQFFQTDLQLTDINDHSPEFPDTEMLLKIQESVQPGTVFPLKAAQDS
                     DIGSNAVQNYTVNPNLHFHVLTHSHTDGRKYPELVLDRALDREEQPELTLILTALDGG
                     APPKSGTTTVRIEVVDINDNAPQFVQSLYAVEVPEDSPLNALVVTVSARDLDTGIHGN
                     VAYSLFQGSGGLQPFVIDEISGEIRLKGALDFEATPYYNMEIVATDSGGLSGKCTVSI
                     QVVDVNDNAPKLTISSLTRSIPENAPEAVVAVFSVSDPDSGDNGRVLCSIQNELPFLL
                     KPTFKNFYTLVTESPLDRESRAEYNITISVSDLGTPRLTTQHTITVQVSDINDNAPTF
                     TQTSYTLFVHENNSPALHIGTISATDADSGSNGFINYSLLPPHDQQLALVSLISINSD
                     NGQLFALRALDYEAVQAFEFHVGATDGGSPALSSQALVRVVVLDDNDNAPFVLYPLQN
                     ASAPCTELLPRAAEPGYLVTKVVAVDADSGQNAWLSFQLLKATEPGLFNVWAHNGEVR
                     TARLLSERDVPKHRLLLVVKDNGEPPRSASIMLQVLVVDGFSQPYLPLPEVALNPTKE
                     EDMLTLYLVIALASVSSLFLLSVLLFVGVRLCRKARAASLGDCSIPEGHFPGHLVDVS
                     SAGTLSQNYHYEVCLTEDSGTSDFKFMNPIIPTSLLQDS"
     misc_feature    88..336
                     /gene="Pcdhb8"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    88..336
                     /gene="Pcdhb8"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    418..714
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    418..714
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(430..435,601..603,607..609,700..702,706..711)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(430..435,601..603,607..609,700..702,706..711)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    739..1026
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    739..1026
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(757..762,919..921,925..927,1012..1014,1018..1023)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(757..762,919..921,925..927,1012..1014,1018..1023)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1060..1338
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1060..1338
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1069..1074,1225..1227,1231..1233,1324..1326,
                     1330..1335)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1069..1074,1225..1227,1231..1233,1324..1326,
                     1330..1335)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1360..1668
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1360..1668
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1381..1386,1555..1557,1561..1563,1654..1656,
                     1660..1665)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1381..1386,1555..1557,1561..1563,1654..1656,
                     1660..1665)
                     /gene="Pcdhb8"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1723..1989
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1723..1989
                     /gene="Pcdhb8"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    2053..2298
                     /gene="Pcdhb8"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
     misc_feature    2053..2298
                     /gene="Pcdhb8"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
     exon            1..2340
                     /gene="Pcdhb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagacag cgctagcaaa aacaccagag aaaaggcaag tcattttcct tgctatattg
       61 ttgcttttgt gggagtctgg ctctgaggca attagatatt ccatgccaga agaaacggag
      121 agtggctact tgatagctaa cctggctaaa gatcttgggc tccagattgg ggaattgtcc
      181 actagagggg cacgaatcca tcacaatggt aacaaagagc tcttgcagct tgatgcaaag
      241 agagggaatt tgctgctgaa ggaaaaacca gatcgcgagg cactgtgtgg ggcgacagaa
      301 ccctgtgtgc tgcacttcca gatcatactg gaaaaccctg tgcagttctt tcaaaccgac
      361 ctgcagctca cagatataaa cgaccactct ccagagttcc ctgacacaga aatgctccta
      421 aaaattcaag aaagtgtcca gccagggact gtgtttcctc tgaaggcagc tcaggactct
      481 gacataggga gcaacgctgt tcagaactac acagtcaatc ccaacctcca tttccacgtc
      541 cttactcaca gtcacacaga tggcaggaaa tacccagagc tggtgctgga cagagccctg
      601 gatagggagg agcagcctga gctcacttta atcctcactg ctctggatgg gggtgctcca
      661 cccaagtctg ggacaacgac ggttcgaatt gaagtcgtgg acatcaatga taacgctccc
      721 caatttgtac agtcgctcta tgcggtggag gtccctgaag atagtcccct caatgcctta
      781 gttgtcacag tctctgccag agacttagat actgggatac atggcaatgt agcctactct
      841 ctgtttcaag gcagtggagg tcttcagcca tttgtgatag atgaaatttc aggagaaatt
      901 cgccttaaag gggcattgga ttttgaggca actccatact ataacatgga aattgtagcc
      961 acagacagcg gaggtctttc gggaaaatgc actgtgtcta tacaggtggt ggatgtgaac
     1021 gacaacgccc ctaaactcac catatcttcg ctcactcgtt ccatcccaga aaatgctcct
     1081 gaggctgtag ttgctgtttt cagtgtttct gacccagatt ctggcgataa tggaagagtg
     1141 ttgtgttcta ttcagaatga acttccattt cttttaaaac ccacattcaa gaacttttac
     1201 accttagtga cagagagccc cctggacaga gagagcagag ctgagtacaa tatcaccatc
     1261 tcagtctcag acctgggcac acccaggctc acaacccagc acaccataac agtgcaggtc
     1321 tctgacatca acgacaacgc tcccaccttc actcaaacat cttataccct gtttgttcac
     1381 gagaacaaca gccccgccct gcacataggc accatcagcg ccacagatgc agactcaggc
     1441 tccaatggct ttattaatta ctcactgcta ccgccccatg accagcagct ggccctcgtc
     1501 tccctcatct ccatcaactc agacaatggg caactgttcg cactcagggc gctggactat
     1561 gaggccgtgc aggcctttga gttccacgtg ggcgctacag atggaggctc acccgcgctc
     1621 agcagtcagg ctctggtgcg cgtggtggtg ctggacgaca atgacaatgc gcccttcgtg
     1681 ctctacccac tgcagaacgc ctctgcgcct tgcacagagt tactgcccag agcagcggag
     1741 ccaggatacc tggttaccaa ggtggttgct gttgatgctg actctggcca gaatgcctgg
     1801 ctgtcattcc agttgcttaa ggccacagag cccgggctgt ttaatgtgtg ggcgcacaat
     1861 ggcgaggtac gcaccgccag gctgctgagc gagcgtgatg tgcccaagca cagactgctg
     1921 ctggtggtca aggacaatgg agagcctcca cgctctgcta gcatcatgct gcaggtgcta
     1981 gtggtggatg gcttctctca gccctacctg cctctgccag aggtggcgct caaccccaca
     2041 aaggaagaag acatgctcac actctatctg gttattgctt tggcttctgt gtcttcactt
     2101 tttctcttgt ctgtgctgct gttcgtgggc gtgaggctgt gcaggaaggc cagggcagct
     2161 tctctgggtg actgttctat tcccgaggga cactttccag gccacctggt ggatgtcagc
     2221 agtgcgggaa ccctgtccca gaattaccat tatgaggtct gtctgactga agactctggg
     2281 acctcagatt tcaagttcat gaaccctatc attcccacca gtctccttca ggactcctag
//
LOCUS       NM_001009968             585 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Spetex-2F protein (Spetex2f), mRNA.
ACCESSION   NM_001009968 XM_006251680 XM_008770541 XM_229523
VERSION     NM_001009968.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Iwamoto,Y., Kaneko,T., Ichinose,J., Mori,T., Shibata,Y.,
            Toshimori,K. and Iida,H.
  TITLE     Molecular cloning of rat Spetex2 family genes mapped on chromosome
            15p16, encoding a 23-kilodalton protein associated with the plasma
            membranes of haploid spermatids
  JOURNAL   Biol Reprod 72 (2), 284-292 (2005)
   PUBMED   15371276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB180081.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008770541.1, XM_006251680.1, XM_229523.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..585
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /note="Spetex-2F protein"
                     /db_xref="GeneID:316940"
                     /db_xref="RGD:1359579"
     CDS             1..585
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /codon_start=1
                     /product="Spetex-2F protein"
                     /protein_id="NP_001009968.1"
                     /db_xref="GeneID:316940"
                     /db_xref="RGD:1359579"
                     /translation="MFHQLLKLVQKERGDQGETRLRQKKTGLLSWFIRKASSENFISN
                     HEKHIKKLEELKLEIQKCKIERDELSRILDLYVNDGLNYRLSVELPMLKSQHEMRMMD
                     MHKMTNWISDAMEKYKELTQENNSYRIRNFQLLNECNELKKNVRILMNENRKLLVEQT
                     ELQASFEEGKRFCEEASKTIYTADIESLCPVTFE"
     misc_feature    100..342
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    100..342
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            1..91
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /inference="alignment:Splign:2.1.0"
     exon            92..251
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /inference="alignment:Splign:2.1.0"
     exon            252..383
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /inference="alignment:Splign:2.1.0"
     exon            384..585
                     /gene="Spetex2f"
                     /gene_synonym="Spetex-2F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttcacc agctgctcaa gctagttcag aaggagaggg gagaccaagg agagaccaga
       61 ctgaggcaga agaaaactgg ccttctgtct tggtttattc ggaaggcatc atcagaaaat
      121 ttcatcagta accatgaaaa gcatataaag aaattggagg aactaaaact tgaaatccag
      181 aagtgtaaaa tcgagcggga tgaactttct cgaatcctgg acctttatgt caatgatggt
      241 ttgaactaca ggctgagtgt tgaattgcca atgcttaaat cccaacatga gatgagaatg
      301 atggatatgc ataagatgac caactggata agtgatgcca tggagaagta caaggagctc
      361 acgcaagaga acaattccta ccgcatcaga aacttccaac tcctgaatga atgcaatgaa
      421 ttgaagaaga atgtaaggat tctgatgaat gagaacagaa aactgctggt ggagcagact
      481 gaactgcaag catcctttga ggagggaaag aggttctgtg aggaggccag caagaccatc
      541 tacaccgcag atattgaatc cttgtgtcct gttacttttg agtaa
//
LOCUS       NM_001009177             339 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus stefin A3-like 1 (Stfa3l1), mRNA.
ACCESSION   NM_001009177 XM_579281
VERSION     NM_001009177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 339)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000375.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579281.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000375.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..339
                     /gene="Stfa3l1"
                     /note="stefin A3-like 1"
                     /db_xref="GeneID:408215"
                     /db_xref="RGD:1302997"
     CDS             1..339
                     /gene="Stfa3l1"
                     /function="cysteine protease inhibitor"
                     /codon_start=1
                     /product="stefin A3-like 1 precursor"
                     /protein_id="NP_001009177.1"
                     /db_xref="GeneID:408215"
                     /db_xref="RGD:1302997"
                     /translation="MGEQQASVSLLCQFPVTSSIPLLTTVILLRVVLPFKWLGCYLVK
                     PLLEEKTNEKYEKFQAVDYKVQVVAGKNYFIKMDVGHIKVFQGLSGEDDLELSGYHTN
                     KTKNDELTSF"
     sig_peptide     1..66
                     /gene="Stfa3l1"
     mat_peptide     67..336
                     /gene="Stfa3l1"
                     /product="stefin A3-like 1"
     misc_feature    <127..318
                     /gene="Stfa3l1"
                     /note="Cystatin domain; Region: Cystatin; pfam00031"
                     /db_xref="CDD:425431"
     misc_feature    <127..318
                     /gene="Stfa3l1"
                     /note="Cystatin domain; Region: Cystatin; pfam00031"
                     /db_xref="CDD:425431"
     misc_feature    order(196..204,208..210)
                     /gene="Stfa3l1"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     misc_feature    order(196..204,208..210)
                     /gene="Stfa3l1"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     exon            1..126
                     /gene="Stfa3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..228
                     /gene="Stfa3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..339
                     /gene="Stfa3l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggtgagc agcaagcctc tgtctctttg ctgtgccaat tccctgttac ctctagcatt
       61 cccctcttga caacagtaat tcttctaaga gtagtcttac cttttaaatg gttgggctgt
      121 tacctggtca aaccattgct tgaagagaaa accaatgaga aatatgaaaa atttcaagct
      181 gttgattata aagttcaagt tgtcgctgga aaaaattact tcattaaaat ggacgtgggg
      241 cacataaaag tcttccaggg tctttctgga gaggatgatt tggaacttag tggttaccat
      301 actaacaaaa ccaagaatga tgagctgacc tccttctaa
//
LOCUS       NM_001270386             345 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus glutathione S-transferase, alpha 4 like 1
            (Gsta4l1), mRNA.
ACCESSION   NM_001270386 XM_003750872 XM_003752350
VERSION     NM_001270386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            AY387069.1.
            
            On or before Jul 3, 2012 this sequence version replaced
            XM_003752350.1, XM_003750872.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY387069.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..345
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /note="glutathione S-transferase, alpha 4 like 1"
                     /db_xref="GeneID:688925"
                     /db_xref="RGD:1582982"
     CDS             1..345
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /codon_start=1
                     /product="uncharacterized protein LOC688925"
                     /protein_id="NP_001257315.1"
                     /db_xref="GeneID:688925"
                     /db_xref="RGD:1582982"
                     /translation="MESICWLLVTTGVEFEEEFLETREQYEKLQKDGCLLFGRVPLVE
                     IDGMLLTQTRAILRFLAAKHNLYGKNLKDRAFKTRISNIPTIKKFLQPGSQRKPPPDG
                     HYDDMVRTVLKF"
     misc_feature    1..201
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /note="The thioredoxin (TRX)-like superfamily is a large,
                     diverse group of proteins containing a TRX fold. Many
                     members contain a classic TRX domain with a redox active
                     CXXC motif. They function as protein disulfide
                     oxidoreductases (PDOs), altering the redox...; Region:
                     Protein Disulfide Oxidoreductases and Other Proteins with
                     a Thioredoxin fold; cl00388"
                     /db_xref="CDD:469754"
     misc_feature    1..201
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /note="The thioredoxin (TRX)-like superfamily is a large,
                     diverse group of proteins containing a TRX fold. Many
                     members contain a classic TRX domain with a redox active
                     CXXC motif. They function as protein disulfide
                     oxidoreductases (PDOs), altering the redox...; Region:
                     Protein Disulfide Oxidoreductases and Other Proteins with
                     a Thioredoxin fold; cl00388"
                     /db_xref="CDD:469754"
     misc_feature    <220..336
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /note="C-terminal, alpha helical domain of the Glutathione
                     S-transferase family; Region: GST_C_family; cl02776"
                     /db_xref="CDD:470672"
     misc_feature    <220..336
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /note="C-terminal, alpha helical domain of the Glutathione
                     S-transferase family; Region: GST_C_family; cl02776"
                     /db_xref="CDD:470672"
     exon            1..222
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /inference="alignment:Splign:2.1.0"
     exon            223..345
                     /gene="Gsta4l1"
                     /gene_synonym="LRRGT00083"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtcga tctgctggct gctggttacg actggagtgg agtttgaaga agaatttctt
       61 gagacaagag aacaatatga gaagttgcaa aaggatggat gcctgctttt tggccgagtt
      121 ccattggtgg aaatagacgg gatgctactg acacagacca gagccatcct caggttcttg
      181 gctgccaagc acaacctata tgggaagaac ctgaaggaca gagcatttaa gacaagaatc
      241 agcaacattc ctacaattaa gaagttcctg caacctggaa gtcagaggaa gccacctcca
      301 gatggtcact atgatgacat ggtcaggacc gtcctgaagt tctag
//
LOCUS       NM_001109229            1860 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus monooxygenase, DBH-like 2 (Moxd2), mRNA.
ACCESSION   NM_001109229 XM_001070939 XM_575443
VERSION     NM_001109229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575443.1, XM_001070939.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN16676807, SAMN16676808
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..1860
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="monooxygenase, DBH-like 2"
                     /db_xref="GeneID:500092"
                     /db_xref="RGD:1564286"
     CDS             1..1860
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /codon_start=1
                     /product="monooxygenase, DBH-like 2 precursor"
                     /protein_id="NP_001102699.1"
                     /db_xref="GeneID:500092"
                     /db_xref="RGD:1564286"
                     /translation="MGYFLFFRLFLLWVLAAFSQGKRLSPTSPLRYSRFLDPSHAVFL
                     RWDFDYETEIITFELQVQTTGWVGLGITDRYTFVGSDLVVGGVLPNGNVYFSDQHLLD
                     EDTLEQDGSQDAELLKLTEDSVSTTMRFSRPFRSCDPHDHDITSDTMRVLAAYGLDDI
                     PKMNRERTFVKSIFLLQILQYDDEDAPEDTVIYDLKISNFLIPEEDTTYACTFLPLPI
                     VSKKHHIYKFEPILVERNETMVHHVLVYACGNSSVLPTGIGECYGADPAFSLCSHVIA
                     GWAVGGLSYQFPDDVGISIGTPFDPQWIRLEIHYSNFQNLPGIRDTSGMRLYYTSHLR
                     KYDMGVLQLGISVFPIHFIPPGAEAFLSYGLCKTDKFEEMNGAPVADIYVSACLLHTH
                     LAGRSLQALQYRNGTQLQIVCKDFSYDFNLQESRDLPHPVVIKPGDELLIECHYQTLD
                     RDFMTFGGASTINEMCLIFFFYYPRINISSCMGYPDIIYVTNELGEEASENPMENLMV
                     LNNVEWTPENIKTAEKACKESQQTVLIKTIDEEVENTTGWIPDIIPTPRGACLESSGG
                     KVEPQDKTPAGFRAVPMALSGSNTATLRHLPMITVLFLQGCLSWLLAMLQTGV"
     sig_peptide     1..63
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    106..477
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="DOMON-like domain of copper-dependent
                     monooxygenases and related proteins; Region: DOMON_DOH;
                     cd09631"
                     /db_xref="CDD:187689"
     misc_feature    106..477
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="DOMON-like domain of copper-dependent
                     monooxygenases and related proteins; Region: DOMON_DOH;
                     cd09631"
                     /db_xref="CDD:187689"
     misc_feature    order(196..198,202..207,241..249,427..429,433..435,
                     454..456)
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187689"
     misc_feature    order(196..198,202..207,241..249,427..429,433..435,
                     454..456)
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:187689"
     misc_feature    577..951
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     N-terminal domain; Region: Cu2_monooxygen; pfam01082"
                     /db_xref="CDD:460053"
     misc_feature    577..951
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     N-terminal domain; Region: Cu2_monooxygen; pfam01082"
                     /db_xref="CDD:460053"
     misc_feature    1006..1446
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     C-terminal domain; Region: Cu2_monoox_C; pfam03712"
                     /db_xref="CDD:461021"
     misc_feature    1006..1446
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     C-terminal domain; Region: Cu2_monoox_C; pfam03712"
                     /db_xref="CDD:461021"
     exon            1..288
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            289..435
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            436..597
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            598..681
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            682..849
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            850..952
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1119
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1211
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1308
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1368
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1499
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1617
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1860
                     /gene="Moxd2"
                     /gene_synonym="RGD1564286"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggctatt ttctcttctt caggcttttc ttactttggg tcctggcagc cttttcccaa
       61 ggcaagcgcc ttagccctac atctcccctt cgttattcca gattcctaga tccttcccat
      121 gctgttttcc tgcgctggga ctttgattat gagactgaga taatcacatt tgaactgcaa
      181 gtccaaacaa ctggctgggt tggcctgggc atcacagatc gctacacgtt tgtgggaagt
      241 gatctggtag ttggaggtgt cctacccaat ggcaatgtct acttttcgga tcagcacctt
      301 ctggatgaag acactctaga acaggatggg agtcaagatg ctgaactcct aaagctcaca
      361 gaagattctg tctcgaccac tatgcgcttt tcccggccct tcagatcctg tgatccacat
      421 gatcatgaca ttacgagtga taccatgagg gtcctggctg cctatggcct ggatgacata
      481 ccaaagatga atcgggagcg tacttttgtc aagtccatct tcttgcttca aatactacaa
      541 tatgatgatg aagatgcccc tgaagacact gtcatctatg acttgaagat cagtaatttc
      601 ctcattccag aggaggatac cacatatgcc tgcacctttc tcccgctccc tattgtcagc
      661 aaaaagcatc acatctacaa gtttgaacct atattggtgg aacgcaatga gacaatggtg
      721 catcatgttc tcgtgtatgc atgcggcaat tctagtgtac tccccacagg catcggtgaa
      781 tgttacggag cagaccctgc cttctccctc tgctcccatg tcatcgcagg ctgggctgtt
      841 gggggcctta gctaccagtt tccagatgat gtaggcatct ctattggaac cccctttgac
      901 cctcaatgga tccgactgga aattcactac agcaattttc agaaccttcc tggtatccgt
      961 gatacctcag ggatgcggct gtactacacc tcgcaccttc gcaaatatga catgggagtc
     1021 ctccagctgg gcatctcagt tttccctatt cactttatac ccccgggtgc tgaggctttc
     1081 ttgtcctatg ggctatgcaa gacagacaag tttgaagaga tgaatggggc tccagtagct
     1141 gacatatatg tatcagcctg cctgctccat acccacttag ctgggcggtc actgcaagct
     1201 ctgcaataca gaaatggaac ccaactccaa atagtatgta aagatttctc ctatgatttc
     1261 aacctgcaag aatctcggga cctacctcat cctgtagtga ttaagccggg ggatgagctg
     1321 ctgatagaat gccattatca gacgctggat cgtgacttca tgacttttgg aggtgccagc
     1381 accattaatg agatgtgcct catcttcttc ttctactatc ccagaattaa catctccagt
     1441 tgcatgggat accctgatat catctatgtg accaatgagc tgggggaaga agcatcagag
     1501 aatcccatgg aaaacctcat ggtcctgaat aatgttgagt ggactccaga gaacattaag
     1561 acagctgaga aagcctgcaa ggagtcccag cagacagtat tgatcaagac gattgatgaa
     1621 gaagtagaaa atacaacagg ttggattccc gatattatac caactcctcg aggagcatgc
     1681 ttagagtctt ctggaggcaa agtggaacct caggacaaga cccctgcagg cttcagggct
     1741 gtaccaatgg ccctctctgg ctccaatact gctactctga ggcacctgcc catgattact
     1801 gtcttgttcc tgcagggttg cctctcatgg ctccttgcaa tgctacagac tggagtatga
//
LOCUS       NM_001008824            1350 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 27 (Krt27), mRNA.
ACCESSION   NM_001008824 XM_579221
VERSION     NM_001008824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004030.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579221.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1350
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="keratin 27"
                     /db_xref="GeneID:450229"
                     /db_xref="RGD:1359115"
     CDS             1..1350
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="K27; CK-27; cytokeratin-27; type I inner root
                     sheath-specific keratin-K25irs3; type I keratin KA40;
                     keratin 27, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 27"
                     /protein_id="NP_001008824.1"
                     /db_xref="GeneID:450229"
                     /db_xref="RGD:1359115"
                     /translation="MSVRFSSASRRLGSVRLSSPGAALGAGNTCGVPGIGSGFSCAFG
                     GSSLAGGLGMGGASCGAFTVNEHGLLSGNEKVTMQNLNDRLASYLENVQALEEANADL
                     EQKIKDWYEKFGPGSCRGLDHDYSRYFPIIDDLRTQIISATAQNANIVLQNDNARLTA
                     DDFRMKYENELALHQSVDADINGLRRVLDELTLCRTDLEVQLETLSEELAYLKKNHEE
                     EMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASL
                     QQQISDDAGATTSARNELTEMKRTLQTLEIELQSLLAMKHSLECSLTETEGNYCTQLA
                     QIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCLLIGGDEGSCVKS
                     KGQGGPGNQTKDSPKTAIVKTVVEELDPRGKVLSSRVHTLEEKSTKVNNKNEQRIPS"
     misc_feature    1..219
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Head. /evidence=ECO:0000255"
     misc_feature    217..1158
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    217..1158
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    220..327
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Coil 1A. /evidence=ECO:0000255"
     misc_feature    328..393
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Linker 1. /evidence=ECO:0000255"
     misc_feature    394..669
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Coil 1B. /evidence=ECO:0000255"
     misc_feature    670..738
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Linker 12. /evidence=ECO:0000255"
     misc_feature    739..1155
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Coil 2. /evidence=ECO:0000255"
     misc_feature    1156..1347
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Tail. /evidence=ECO:0000255"
     misc_feature    1273..1347
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..414
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            415..497
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            498..654
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            655..816
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            817..942
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1160
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1210
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1350
                     /gene="Krt27"
                     /gene_synonym="Ka40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgttc gtttttcctc cgcatccaga cgcctgggct ctgtgaggct ctccagcccg
       61 ggagcagcct tgggggctgg aaatacctgc ggagtgccag gcatcggaag tggcttctcc
      121 tgcgcctttg ggggcagctc attggcaggg ggtctcggca tgggcggtgc ttcctgtggg
      181 gccttcactg tgaatgagca tggcctcctt tccggcaatg agaaggtaac catgcagaac
      241 ctcaatgacc gcctggcttc ctacctggag aatgtacaag cactagagga ggccaacgct
      301 gacctggagc agaagatcaa ggactggtat gaaaaatttg gacctgggtc gtgccgcggt
      361 cttgatcatg actacagtag atacttcccc atcattgatg acctcaggac ccagataatc
      421 tctgcaactg cacaaaacgc caacatcgtc ctgcaaaatg acaacgcgag actgacggcg
      481 gacgacttca gaatgaagta cgagaacgaa ctggcgctcc accagagcgt cgatgcggac
      541 atcaatggct tgcggagggt cctggatgag ctgaccctgt gcagaaccga ccttgaggtc
      601 cagctggaaa cactcagtga ggagctggct tatctcaaga agaaccatga ggaggaaatg
      661 caggctctgc agtgcgcggc cggaggtaac gtgaatgtgg agatgaacgc agcccccggc
      721 gtggacctca ccgtcttgct gaacaacatg cgagccgagt acgaggccct ggctgagcag
      781 aaccgcaggg acgccgaggc ctggttccaa gagaagagcg cttccctgca gcagcagatt
      841 tcagacgatg ctggagccac cacctcagcc aggaacgaac tcactgagat gaaacggact
      901 ctccaaaccc tggagataga gctgcagtcc ctcttagcca tgaaacactc tctggagtgc
      961 tccctgacgg agaccgaggg caactactgc acgcagctgg ctcagatcca ggctcagatc
     1021 agcgccctgg aggagcagct gcaccaggtg aggacggaga ccgagggcca gaagctggaa
     1081 tatgagcagc tgctgaacgt caaggcccac ctggagaagg agatcgagac ctactgcctc
     1141 ctcataggag gagacgaggg ctcttgtgtt aagtcaaaag gccaaggagg acccggaaat
     1201 cagacaaagg attcacctaa aactgccatt gttaaaactg tcgtcgaaga attagatccc
     1261 cgtggcaagg ttctgtcctc ccgagtccac accctggaag agaaatccac caaagtcaac
     1321 aacaagaacg agcagaggat cccttcttga
//
LOCUS       NM_001024686             915 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 108 (Tas2r108),
            mRNA.
ACCESSION   NM_001024686
VERSION     NM_001024686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 915)
  AUTHORS   Krasteva,G., Canning,B.J., Hartmann,P., Veres,T.Z., Papadakis,T.,
            Muhlfeld,C., Schliecker,K., Tallini,Y.N., Braun,A., Hackstein,H.,
            Baal,N., Weihe,E., Schutz,B., Kotlikoff,M., Ibanez-Tallon,I. and
            Kummer,W.
  TITLE     Cholinergic chemosensory cells in the trachea regulate breathing
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9478-9483 (2011)
   PUBMED   21606356
REFERENCE   2  (bases 1 to 915)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   3  (bases 1 to 915)
  AUTHORS   Wu,S.V., Chen,M.C. and Rozengurt,E.
  TITLE     Genomic organization, expression, and function of bitter taste
            receptors (T2R) in mouse and rat
  JOURNAL   Physiol Genomics 22 (2), 139-149 (2005)
   PUBMED   15886333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY916510.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY916510.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..915
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="taste receptor, type 2, member 108"
                     /db_xref="GeneID:554302"
                     /db_xref="RGD:1561194"
     CDS             1..915
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="T2R4; T2R20; taste receptor type 2 member 20;
                     bitter taste receptor T2R16"
                     /codon_start=1
                     /product="taste receptor type 2 member 4"
                     /protein_id="NP_001019857.1"
                     /db_xref="GeneID:554302"
                     /db_xref="RGD:1561194"
                     /translation="MLWELYAFVFAASVVFNFVGIVANLFIIVIISKTWVKSHKISSS
                     DKILFSLAITRFLTLGLFLLNTVYIATNTGRSVYFSTFFLLCWKFLDSNSLWLVTFLN
                     CLYCVKITHFQHPVFLLLKRTVSMKTTSLLLACLLISAFTTLLYFVLTQISRFPEHII
                     GRNDTLFDVSDGILTLAASLILSSLLQFLLNVTFASLLIHSLRRHVQKMQRNRSSFWN
                     PQTEAHVGAMRLMICFLVLYIPYSIAALLYFPSYMRKNLRAQAACMIITAAYPPGHSI
                     LLIITHHKLKAKAKKICCFYKLRDFVSN"
     misc_feature    19..843
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="mammalian taste receptor 2, subtype 4, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R4; cd15013"
                     /db_xref="CDD:320141"
     misc_feature    19..843
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="mammalian taste receptor 2, subtype 4, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R4; cd15013"
                     /db_xref="CDD:320141"
     misc_feature    22..99
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320141"
     misc_feature    22..99
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320141"
     misc_feature    31..93
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320141"
     misc_feature    133..207
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320141"
     misc_feature    139..201
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    241..309
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320141"
     misc_feature    241..309
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320141"
     misc_feature    241..303
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    388..438
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320141"
     misc_feature    388..438
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320141"
     misc_feature    487..489
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET0.1); glycosylation site"
     misc_feature    514..576
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    517..588
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320141"
     misc_feature    517..588
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320141"
     misc_feature    661..738
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320141"
     misc_feature    661..738
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320141"
     misc_feature    688..750
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     misc_feature    769..843
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320141"
     misc_feature    769..843
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320141"
     misc_feature    781..843
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET0.1);
                     transmembrane region"
     exon            1..915
                     /gene="Tas2r108"
                     /gene_synonym="T2R16; Tas2r4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctctggg aactgtatgc atttgtgttt gccgcctcag ttgtttttaa ttttgtagga
       61 atagttgcaa atttatttat tatagtgata atttctaaga cttgggtcaa aagtcacaaa
      121 atctcctctt cagataagat cctgttcagc ttggccatca ctagattcct gaccctgggg
      181 ttgtttctac tgaacactgt ctacattgct acaaacactg gaaggtcagt ctacttttcc
      241 acgttttttc tcttgtgttg gaagtttctg gactccaaca gtctctggct agtgaccttt
      301 ctgaactgct tgtattgcgt gaagatcact catttccaac atccagtgtt tcttctgttg
      361 aaacggactg tctctatgaa gaccaccagc ctgctgctgg cctgccttct gatttctgcc
      421 ttcaccactc tcctatattt tgtgctcaca cagatatcac gttttcctga acacataatt
      481 gggagaaatg acacattatt tgacgtcagt gatggcatct tgacgttagc ggcttctttg
      541 atcctgagct cacttttaca gtttctgctc aatgtgacct ttgcttcttt gctaatacat
      601 tccctgagaa gacatgtaca gaagatgcag agaaacagga gcagcttttg gaatccccag
      661 acggaggctc acgtgggcgc catgaggctg atgatctgtt tcctcgtgct ctatattcca
      721 tattcaatcg ctgccttgct ctatttccct tcctatatga ggaagaatct gagagcccag
      781 gctgcttgca tgatcattac tgctgcttac cctccaggac attctatcct ccttattatc
      841 acacatcaca aactgaaagc taaagcaaag aagatttgct gtttctacaa attgcgggat
      901 ttcgttagta actga
//
LOCUS       NM_001106177            1514 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus heat shock transcription factor 4 (Hsf4), mRNA.
ACCESSION   NM_001106177 XM_001075468 XM_214668
VERSION     NM_001106177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Ho,E.A. and Piquette-Miller,M.
  TITLE     KLF6 and HSF4 transcriptionally regulate multidrug resistance
            transporters during inflammation
  JOURNAL   Biochem Biophys Res Commun 353 (3), 679-685 (2007)
   PUBMED   17196161
  REMARK    GeneRIF: KLF6 and HSF4 are stimuli-specific regulatory elements
            which may be important in the control of the rat mdr1b and mrp3
            genes during health and disease.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Talamas,E., Jackson,L., Koeberl,M., Jackson,T., McElwee,J.L.,
            Hawes,N.L., Chang,B., Jablonski,M.M. and Sidjanin,D.J.
  TITLE     Early transposable element insertion in intron 9 of the Hsf4 gene
            results in autosomal recessive cataracts in lop11 and ldis1 mice
  JOURNAL   Genomics 88 (1), 44-51 (2006)
   PUBMED   16595169
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Hu,Y. and Mivechi,N.F.
  TITLE     Association and regulation of heat shock transcription factor 4b
            with both extracellular signal-regulated kinase mitogen-activated
            protein kinase and dual-specificity tyrosine phosphatase DUSP26
  JOURNAL   Mol Cell Biol 26 (8), 3282-3294 (2006)
   PUBMED   16581800
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Min,J.N., Zhang,Y., Moskophidis,D. and Mivechi,N.F.
  TITLE     Unique contribution of heat shock transcription factor 4 in ocular
            lens development and fiber cell differentiation
  JOURNAL   Genesis 40 (4), 205-217 (2004)
   PUBMED   15593327
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Fujimoto,M., Izu,H., Seki,K., Fukuda,K., Nishida,T., Yamada,S.,
            Kato,K., Yonemura,S., Inouye,S. and Nakai,A.
  TITLE     HSF4 is required for normal cell growth and differentiation during
            mouse lens development
  JOURNAL   EMBO J 23 (21), 4297-4306 (2004)
   PUBMED   15483628
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Somasundaram,T. and Bhat,S.P.
  TITLE     Developmentally dictated expression of heat shock factors:
            exclusive expression of HSF4 in the postnatal lens and its specific
            interaction with alphaB-crystallin heat shock promoter
  JOURNAL   J Biol Chem 279 (43), 44497-44503 (2004)
   PUBMED   15308659
  REMARK    GeneRIF: HSF4 binds to alphaB-crystallin, Hsp70, and Hsp82
            promoters and has a role in interacting with the canonical heat
            shock element of the alphaB-crystallin gene [HSF4]
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Jablonski,M.M., Lu,L., Wang,X., Chesler,E.J., Carps,E., Qi,S.,
            Gu,J. and Williams,R.W.
  TITLE     The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near
            cadherin 1
  JOURNAL   Mol Vis 10, 577-587 (2004)
   PUBMED   15343150
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Bu,L., Jin,Y., Shi,Y., Chu,R., Ban,A., Eiberg,H., Andres,L.,
            Jiang,H., Zheng,G., Qian,M., Cui,B., Xia,Y., Liu,J., Hu,L.,
            Zhao,G., Hayden,M.R. and Kong,X.
  TITLE     Mutant DNA-binding domain of HSF4 is associated with autosomal
            dominant lamellar and Marner cataract
  JOURNAL   Nat Genet 31 (3), 276-278 (2002)
   PUBMED   12089525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075468.1, XM_214668.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760475,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1514
                     /gene="Hsf4"
                     /note="heat shock transcription factor 4"
                     /db_xref="GeneID:291960"
                     /db_xref="RGD:1310808"
     exon            1..190
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Hsf4"
                     /note="upstream in-frame stop codon"
     CDS             139..1338
                     /gene="Hsf4"
                     /codon_start=1
                     /product="heat shock factor protein 4"
                     /protein_id="NP_001099647.1"
                     /db_xref="GeneID:291960"
                     /db_xref="RGD:1310808"
                     /translation="MGAGRRPRHRPPHPLEPDGFRKVVSIEQGGLLRPERDHVEFQHP
                     SFVRGCEQLLERVRRKVPALRGDDTRWRPEDLGRLLGEVQALRGVQESTEARLQELRQ
                     QNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAKRKLSLMLDEGSACS
                     ASAKFNACPVSGALLQDPYFIQSPSTCSPSQRPPWASALTGPEGLSSLTSQKTAHLLK
                     DTGFLPPVLAGAPPPLPVAVVQAILEGKGSFSPEGPRSIQQPEPRGPREVPDRGTLGL
                     DRGNRSPESLLPPVLLRPPPETVEPMDALGPSLHGREWTLMDLDMELSLMQPLAPERA
                     EAELTVKDLTSSGVGKDHTLGTPLMLDVQADLEGAALSVPGALTLYNATESNASYLDP
                     GASPSSP"
     misc_feature    <190..318
                     /gene="Hsf4"
                     /note="HSF-type DNA-binding; Region: HSF_DNA-bind;
                     cl12113"
                     /db_xref="CDD:472277"
     misc_feature    <190..318
                     /gene="Hsf4"
                     /note="HSF-type DNA-binding; Region: HSF_DNA-bind;
                     cl12113"
                     /db_xref="CDD:472277"
     exon            191..318
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            319..443
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..519
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..584
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            585..687
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..826
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..950
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1047
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1113
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1183
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1514
                     /gene="Hsf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactttcacg gctttgacaa gcccgcagcg gccgggctgg aacgctgagc ccggccgaga
       61 ctgcgccatg caggaagcgc cagctgcgct gcccacggag ccaggcccca gcccggtacc
      121 tgccttcctc ggcaagctat gggcgctggt aggcgaccca ggcaccgacc acctcatccg
      181 ctggagcccg atggttttcg gaaggtggtg agcatcgagc aaggtggcct gctaagacca
      241 gagcgtgacc acgttgagtt tcagcatccg agcttcgtgc gaggctgtga gcagctactg
      301 gagcgcgtgc gccgcaaggt acctgcgctg cgaggtgatg acactcgatg gcgtcctgaa
      361 gacctgggcc gactgctggg agaggtgcaa gctttgaggg gagtgcagga gagcacggag
      421 gcacggctgc aggaactcag gcagcagaac gagatcttgt ggcgagaggt ggtgacgctg
      481 cggcagagcc acagtcagca gcaccgggtc atcggcaagc taatccagtg cctgtttggg
      541 ccacttcaga cagggcccag cagtacagga gccaagagaa agctgtccct aatgctagat
      601 gaggggagtg catgttcagc atctgccaaa ttcaatgcct gccctgtgtc tggtgctctg
      661 ctccaggacc cctactttat ccagtcgcct tctacttgca gcccctccca gagaccaccg
      721 tgggcctcag ccctcacagg gccagagggc ctatcatctc tgacatccca gaagactgcc
      781 catctcctga aggacacagg ctttctccct ccagtgctgg caggagcacc cccaccgctg
      841 cccgtggctg tggtgcaggc catcctggaa gggaaaggga gcttcagccc tgaggggccc
      901 aggagcatac aacagcctga accaaggggc cccagggagg tacctgacag gggaactctg
      961 ggcctggatc gcggtaaccg gagcccagag agtctgctgc cccccgtgct gcttcggcct
     1021 ccccctgaaa ctgtggagcc catggatgcg ctgggtccta gcctgcatgg acgagaatgg
     1081 accttgatgg atctggacat ggagttgtct ctgatgcagc ctttggctcc agagagggct
     1141 gaagctgagc tgacagtcaa ggacttgact tcttcaggtg tagggaaaga ccacacgctg
     1201 ggaaccccac tcatgctaga tgttcaggcg gatttggagg gtgcagcact atcggtgcct
     1261 ggggctttaa ccctgtacaa tgccaccgag agcaatgctt cctacttgga tcctggagcc
     1321 agtccctcct ctccctgaga tctgcacccc tctgaaaaag cctggctaag gagccagcac
     1381 gcaacagcac acccctttag gcttcctggc gcccccgccc ccgccctggg aggtgagcga
     1441 agccctccta tatgtgacag cctctctcca ctaccccagt gaaccctgca acataaactg
     1501 cattccctac tctg
//
LOCUS       NM_001009532            1029 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 3 (Taar3), mRNA.
ACCESSION   NM_001009532 XM_579306
VERSION     NM_001009532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Staubert,C., Boselt,I., Bohnekamp,J., Rompler,H., Enard,W. and
            Schoneberg,T.
  TITLE     Structural and functional evolution of the trace amine-associated
            receptors TAAR3, TAAR4 and TAAR5 in primates
  JOURNAL   PLoS One 5 (6), e11133 (2010)
   PUBMED   20559446
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Liberles,S.D. and Buck,L.B.
  TITLE     A second class of chemosensory receptors in the olfactory
            epithelium
  JOURNAL   Nature 442 (7103), 645-650 (2006)
   PUBMED   16878137
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702317.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579306.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1029
                     /gene="Taar3"
                     /note="trace amine-associated receptor 3"
                     /db_xref="GeneID:494319"
                     /db_xref="RGD:1359566"
     CDS             1..1029
                     /gene="Taar3"
                     /note="taR-3; trace amine receptor 3"
                     /codon_start=1
                     /product="trace amine-associated receptor 3"
                     /protein_id="NP_001009532.1"
                     /db_xref="GeneID:494319"
                     /db_xref="RGD:1359566"
                     /translation="MDLIYIPEDLSSCPKFGNKSCPPTNRSFRVRLIMYLLMTGAMVI
                     TIFGNLVIIISISHFKQLHSPTNFLILSMATTDFLLGFVIMPYSMVRSVESCWYFGDS
                     FCKFHASFDMMLSLTSIFHLCSIAIDRFYAVCAPLHYTTTMTASMIKRLLFFCWAAPA
                     LFSFGLVLSEANVSGMQSYEILIACFNFCALTFNKFWGTILFTTCFFTPGSIMVGIYG
                     KIFIVSRRHARALGNMPENTKGAGRNLSKKKDRKAAKTLGIVMGVFLACWLPCFLAVL
                     IDPYLDYSTPIIVLDLLVWLGYFNSTCNPLIHGFFYPWFRKALEHIVSGKIFRSNSDT
                     ANLFPEAH"
     misc_feature    52..54
                     /gene="Taar3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD24.1); glycosylation site"
     misc_feature    73..75
                     /gene="Taar3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD24.1); glycosylation site"
     misc_feature    97..957
                     /gene="Taar3"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    97..957
                     /gene="Taar3"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    97..177
                     /gene="Taar3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    97..177
                     /gene="Taar3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    106..168
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    196..276
                     /gene="Taar3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    196..276
                     /gene="Taar3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    205..267
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    310..402
                     /gene="Taar3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    310..402
                     /gene="Taar3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    order(319..321,331..336,343..348,571..573,592..594,
                     601..606,613..615,802..804,811..816,823..825,868..870,
                     880..882,892..894)
                     /gene="Taar3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    order(319..321,331..336,343..348,571..573,592..594,
                     601..606,613..615,802..804,811..816,823..825,868..870,
                     880..882,892..894)
                     /gene="Taar3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    436..507
                     /gene="Taar3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    436..507
                     /gene="Taar3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    451..504
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    517..579
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    517..558
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     Region: Extracellular Loop 2 (ECL2).
                     /evidence=ECO:0000250|UniProtKB:Q5QD04"
     misc_feature    580..669
                     /gene="Taar3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    580..669
                     /gene="Taar3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    595..669
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    742..834
                     /gene="Taar3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    742..834
                     /gene="Taar3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    769..831
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     misc_feature    859..936
                     /gene="Taar3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    859..936
                     /gene="Taar3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    859..921
                     /gene="Taar3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD24.1);
                     transmembrane region"
     exon            1..1029
                     /gene="Taar3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatctaa tatacattcc tgaagactta tccagctgtc caaaattcgg aaataaatcc
       61 tgccctccca ccaatcgctc tttccgtgtg cgcttgatca tgtacctgct tatgaccgga
      121 gccatggtta tcaccatctt cggaaacttg gtgataatca tttccatatc gcatttcaaa
      181 cagctacact ctcccaccaa cttcctgatc ctctccatgg caaccaccga cttcctgctg
      241 ggatttgtca tcatgcctta cagcatggtg agatcagtgg agagctgctg gtatttcgga
      301 gacagctttt gcaaattcca cgcaagcttc gacatgatgc taagcctgac ttccattttc
      361 catctgtgct ccatcgctat tgaccggttt tacgcagtgt gtgccccttt gcactacacc
      421 accaccatga cggcgtccat gatcaagaga ctgctgtttt tttgctgggc ggccccagct
      481 ctcttttctt tcggtttagt tctgtcagag gccaatgttt ctggtatgca gagctacgag
      541 attctcattg cttgcttcaa tttctgtgcg cttacgttta acaaattttg ggggaccata
      601 ctgttcacga cctgcttttt tactcctggc tccatcatgg ttggtattta tggtaaaatt
      661 tttattgttt ccagacgaca tgctcgagcc ctcggcaata tgcctgagaa cacaaaagga
      721 gcagggagaa acctgtctaa gaaaaaggac aggaaagcag ccaagactct cggtatcgtc
      781 atgggggtgt ttctggcgtg ctggctacct tgttttctgg ctgtcttgat tgatccatat
      841 ttagactact ctaccccaat catagttctc gatcttctgg tatggctcgg gtacttcaac
      901 tctacttgca accccctcat ccatggcttt ttttacccat ggtttcgcaa agctcttgag
      961 catatagtgt caggaaaaat atttcgctcc aattcagaca ctgcaaacct ttttcctgaa
     1021 gcacattaa
//
LOCUS       NM_207588               1014 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus oxoglutarate receptor 1 (Oxgr1), mRNA.
ACCESSION   NM_207588 XM_224529
VERSION     NM_207588.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1014)
  AUTHORS   Kerschner,J.E., Hong,W., Taylor,S.R., Kerschner,J.A., Khampang,P.,
            Wrege,K.C. and North,P.E.
  TITLE     A novel model of spontaneous otitis media with effusion (OME) in
            the Oxgr1 knock-out mouse
  JOURNAL   Int J Pediatr Otorhinolaryngol 77 (1), 79-84 (2013)
   PUBMED   23200873
REFERENCE   2  (bases 1 to 1014)
  AUTHORS   Inbe,H., Watanabe,S., Miyawaki,M., Tanabe,E. and Encinas,J.A.
  TITLE     Identification and characterization of a cell-surface receptor,
            P2Y15, for AMP and adenosine
  JOURNAL   J Biol Chem 279 (19), 19790-19799 (2004)
   PUBMED   15001573
  REMARK    GeneRIF: P2Y15 is a cell surface receptor for AMP and adenosine
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY191367.1.
            
            On Aug 30, 2004 this sequence version replaced XM_224529.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY191367.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..1014
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="oxoglutarate receptor 1"
                     /db_xref="GeneID:290493"
                     /db_xref="RGD:1303155"
     CDS             1..1014
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="P2Y purinoceptor 15; alpha-ketoglutarate receptor
                     1; G protein-coupled receptor 80; oxoglutarate
                     (alpha-ketoglutarate) receptor 1"
                     /codon_start=1
                     /product="2-oxoglutarate receptor 1"
                     /protein_id="NP_997471.1"
                     /db_xref="GeneID:290493"
                     /db_xref="RGD:1303155"
                     /translation="MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIF
                     LVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFG
                     DFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVI
                     SLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCY
                     TTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSI
                     ESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCS
                     NNP"
     misc_feature    67..69
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6Y1R5.1); glycosylation site"
     misc_feature    103..939
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="2-oxoglutarate receptor 1, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_OXGR1; cd15375"
                     /db_xref="CDD:320497"
     misc_feature    103..939
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="2-oxoglutarate receptor 1, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_OXGR1; cd15375"
                     /db_xref="CDD:320497"
     misc_feature    103..183
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320497"
     misc_feature    103..183
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320497"
     misc_feature    112..174
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    202..279
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320497"
     misc_feature    202..279
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320497"
     misc_feature    208..270
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    order(265..267,274..279,316..333,337..342,349..351,
                     484..486,490..504,544..546,550..558,583..585,592..600,
                     604..612,616..621,760..762,769..774,778..783,790..792,
                     838..843,847..855,862..864,871..876)
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320497"
     misc_feature    order(265..267,274..279,316..333,337..342,349..351,
                     484..486,490..504,544..546,550..558,583..585,592..600,
                     604..612,616..621,760..762,769..774,778..783,790..792,
                     838..843,847..855,862..864,871..876)
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320497"
     misc_feature    316..408
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320497"
     misc_feature    316..408
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320497"
     misc_feature    349..411
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    442..510
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320497"
     misc_feature    442..510
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320497"
     misc_feature    454..516
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    583..672
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320497"
     misc_feature    583..672
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320497"
     misc_feature    601..663
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    700..792
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320497"
     misc_feature    700..792
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320497"
     misc_feature    727..789
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     misc_feature    841..918
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320497"
     misc_feature    841..918
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320497"
     misc_feature    853..915
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Y1R5.1);
                     transmembrane region"
     exon            1..1014
                     /gene="Oxgr1"
                     /gene_synonym="Gpr80; P2Y15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgattgaga cactggacag cccagccaat gattctgatt tcctggatta cataactgct
       61 ttggaaaact gcactgatga gcaaatctca ttcaagatgc agtaccttcc cgtcatctac
      121 agcatcatct ttctcgtggg cttcccggga aatacggtgg cgatttccat ctacgttttc
      181 aagatgcgac cttggaagag cagtaccatc atcatgctga acctggcctt gacggacttg
      241 ctgtatctga ccagcctccc tttcctcatc cattattacg cgagcggtga aaactggatc
      301 ttcggggatt tcatgtgcaa gttcatccga tttggcttcc atttcaacct ttacagcagc
      361 atcctcttcc tcacctgctt tagcctcttc cgttacattg tgatcattca cccgatgagc
      421 tgtttttcta ttcagaagac tcgatgggcg gtggtggctt gtgctggggt gtgggtcatt
      481 tctttggtag ctgtcatgcc catgactttc ctgatcacat caaccacccg gaccaatagg
      541 tctgcttgcc ttgacctcac cagctcagat gacctcacta ctatcaaatg gtacaatctc
      601 attttgacgg ctaccacttt ctgcctgccc ttgctgatag tgacactctg ctacacgacg
      661 attatcagca ccctgactca cggacctcgg acccacagct gctttaagca gaaggctcgg
      721 aggctgacga tcctgctcct ccttgtgttc tatgtatgct ttttaccctt ccacatcctt
      781 agggtcattc ggatcgaatc tcgcctgctt tcaatcagct gctccatcga gagtcacatc
      841 cacgaagctt acattgtctc taggccatta gctgccctca acacctttgg caacctgctg
      901 ttatatgtcg tcgtcagcaa taacttccag caggcattct gctccgcagt gagatgtaaa
      961 gccatcgggg accttgaaca agcaaagaaa gacagttgct caaacaaccc ctga
//
LOCUS       NM_019341                546 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 5 (Rgs5), mRNA.
ACCESSION   NM_019341
VERSION     NM_019341.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Hong,K., Li,M., Nourian,Z., Meininger,G.A. and Hill,M.A.
  TITLE     Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5
            (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries:
            Impaired Trafficking of RGS5 in Hypertension
  JOURNAL   Hypertension 70 (6), 1264-1272 (2017)
   PUBMED   29061726
  REMARK    GeneRIF: AT1R activation results in translocation of RGS5 toward
            the plasma membrane, limiting AT1R-mediated vasoconstriction
            through its role in Gq/11 protein-dependent signaling.
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   3  (bases 1 to 546)
  AUTHORS   Zhao,P. and Chidiac,P.
  TITLE     Regulation of RGS5 GAP activity by GPSM3
  JOURNAL   Mol Cell Biochem 405 (1-2), 33-40 (2015)
   PUBMED   25842189
  REMARK    GeneRIF: The enhancement of RGS5 activity by GPSM3 is maintained
            under these conditions.
REFERENCE   4  (bases 1 to 546)
  AUTHORS   Bokenkamp,R., van Brempt,R., van Munsteren,J.C., van den
            Wijngaert,I., de Hoogt,R., Finos,L., Goeman,J., Groot,A.C.,
            Poelmann,R.E., Blom,N.A. and DeRuiter,M.C.
  TITLE     Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes
            identified by transcriptional profiling of laser-capture
            microdissected endothelial and smooth muscle cells
  JOURNAL   PLoS One 9 (1), e86892 (2014)
   PUBMED   24489801
  REMARK    GeneRIF: Rgs5 and Dlx1 represent novel molecular targets for the
            regulation of ductus arteriosus maturation and closure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 546)
  AUTHORS   Zarzuelo,M.J., Jimenez,R., Galindo,P., Sanchez,M., Nieto,A.,
            Romero,M., Quintela,A.M., Lopez-Sepulveda,R., Gomez-Guzman,M.,
            Bailon,E., Rodriguez-Gomez,I., Zarzuelo,A., Galvez,J., Tamargo,J.,
            Perez-Vizcaino,F. and Duarte,J.
  TITLE     Antihypertensive effects of peroxisome proliferator-activated
            receptor-beta activation in spontaneously hypertensive rats
  JOURNAL   Hypertension 58 (4), 733-743 (2011)
   PUBMED   21825230
REFERENCE   6  (bases 1 to 546)
  AUTHORS   Wang,X., Adams,L.D., Pabon,L.M., Mahoney,W.M. Jr., Beaudry,D.,
            Gunaje,J., Geary,R.L., Deblois,D. and Schwartz,S.M.
  TITLE     RGS5, RGS4, and RGS2 expression and aortic contractibility are
            dynamically co-regulated during aortic banding-induced hypertrophy
  JOURNAL   J Mol Cell Cardiol 44 (3), 539-550 (2008)
   PUBMED   18207159
  REMARK    GeneRIF: After 2 days of aortic banding-induced hypertrophy,
            thoracic aorta lost expression of Rgs5, it returned to normal at 1
            week and increased many fold at 28 days, indicating that RGS
            expression and function correlate with vascular remodeling.
REFERENCE   7  (bases 1 to 546)
  AUTHORS   Grayson,T.H., Ohms,S.J., Brackenbury,T.D., Meaney,K.R., Peng,K.,
            Pittelkow,Y.E., Wilson,S.R., Sandow,S.L. and Hill,C.E.
  TITLE     Vascular microarray profiling in two models of hypertension
            identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets
  JOURNAL   BMC Genomics 8, 404 (2007)
   PUBMED   17986358
  REMARK    GeneRIF: changes in common to caveolin-1 expression and G protein
            signalling, through attenuation of Rgs2 and Rgs5, may contribute to
            hypertension through augmentation of vasoconstrictor pathways
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 546)
  AUTHORS   Lovschall,H., Mitsiadis,T.A., Poulsen,K., Jensen,K.H. and
            Kjeldsen,A.L.
  TITLE     Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth
            muscle cell axis in response to pulp injury
  JOURNAL   Int J Dev Biol 51 (8), 715-721 (2007)
   PUBMED   17939118
  REMARK    GeneRIF: Rgs5 and Notch3 are expressed in pericytes of developing
            and injured teeth and have roles along with vascular-derived stem
            cells during pulp healing
REFERENCE   9  (bases 1 to 546)
  AUTHORS   Wang,Q., Liu,M., Mullah,B., Siderovski,D.P. and Neubig,R.R.
  TITLE     Receptor-selective effects of endogenous RGS3 and RGS5 to regulate
            mitogen-activated protein kinase activation in rat vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 277 (28), 24949-24958 (2002)
   PUBMED   12006602
  REMARK    GeneRIF: role in regulating mitogen-activated protein kinase
            activation in rat vascular smooth muscle cells
REFERENCE   10 (bases 1 to 546)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF241259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF241259.1, EF568934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..546
                     /gene="Rgs5"
                     /note="regulator of G-protein signaling 5"
                     /db_xref="GeneID:54294"
                     /db_xref="RGD:3568"
     CDS             1..546
                     /gene="Rgs5"
                     /codon_start=1
                     /product="regulator of G-protein signaling 5"
                     /protein_id="NP_062214.1"
                     /db_xref="GeneID:54294"
                     /db_xref="RGD:3568"
                     /translation="MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKP
                     EKPAKAHKPSLEEVLQWRQSLDKLLQSNYGFASFKSFLKSEFSEENLEFWVACENYKK
                     IKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPHSFDLAQKRIYA
                     LMEKDSLPRFVRSEFYKELIN"
     misc_feature    193..534
                     /gene="Rgs5"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS5 protein; Region: RGS_RGS5; cd08717"
                     /db_xref="CDD:188672"
     misc_feature    193..534
                     /gene="Rgs5"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS5 protein; Region: RGS_RGS5; cd08717"
                     /db_xref="CDD:188672"
     exon            1..44
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            45..155
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..217
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            218..384
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
     exon            385..546
                     /gene="Rgs5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgtaagg gactggcagc tctgccacac tcatgcctgg aaagggccaa agagatcaag
       61 atcaaattgg gtattcttct ccagaagcca gactctgctg ttgaccttgt cattccatat
      121 aatgagaagc cagagaagcc tgccaaggcg cacaagccct cgctggagga ggtcctgcaa
      181 tggcgccaat ccctggacaa acttctccag agcaactacg gatttgccag cttcaaaagt
      241 ttcctgaagt ctgaattcag tgaggaaaac cttgagttct gggttgcctg tgagaattac
      301 aagaagatca agtcccccat caaaatggca gagaaggcaa agcaaatcta tgaagaattc
      361 atccagacag aggcccctaa agaggtgaac attgaccact tcactaaaga catcaccatg
      421 aagaacctgg tggaaccttc ccctcacagc tttgacctgg cccagaaaag gatctacgcc
      481 ctgatggaga aggattctct gccccgcttc gtgcgctctg agttttataa ggagttaatc
      541 aactag
//
LOCUS       NM_001106965             996 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAGE family member B3 (Mageb3), mRNA.
ACCESSION   NM_001106965 XM_001061758 XM_229038
VERSION     NM_001106965.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473966.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061758.1, XM_229038.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..996
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="MAGE family member B3"
                     /db_xref="GeneID:302746"
                     /db_xref="RGD:1562343"
     CDS             1..996
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="melanoma antigen family B, 3"
                     /codon_start=1
                     /product="melanoma-associated antigen B3"
                     /protein_id="NP_001100435.1"
                     /db_xref="GeneID:302746"
                     /db_xref="RGD:1562343"
                     /translation="MPRGQKRKLHAGKKCYQAGGETQDLQGAQALAEVEKSCPPPSSP
                     HVGVTAHTKSASKLQTTSKVPQRALSTTESKGLSHTRPCKVAKYKIKRKQQSSQTSPS
                     TEKCPRSSLTSTVRLVVNYMMNMCKMKRPILKADVMKMVTNTHKVHIAEILRRASFNL
                     EVLLGVDLKEADSMDSYTLASKMNLPNNGVLTTGRGFPKTGLLMNLLGVIFLKGNCAT
                     EESIWEFLNKMKIYDGKKHFIFGEPRKLITQDLVKLKYLEYRQVPNRSPTSYEFLWGP
                     RSHAETSKMKILKFLAKINHIVPSAFQSRYDEALKDEEERSQAAATFGDTTINTK"
     misc_feature    13..261
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="Melanoma associated antigen family N terminal;
                     Region: MAGE_N; pfam12440"
                     /db_xref="CDD:463582"
     misc_feature    13..261
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="Melanoma associated antigen family N terminal;
                     Region: MAGE_N; pfam12440"
                     /db_xref="CDD:463582"
     misc_feature    <595..855
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     misc_feature    <595..855
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     exon            1..996
                     /gene="Mageb3"
                     /gene_synonym="RGD1562343"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcctcggg gtcagaagag aaagctccat gctggaaaaa aatgctacca ggctggaggt
       61 gagacccagg atctccaggg tgcccaggcc cttgcagaag tggagaaaag ctgtccccct
      121 ccatcttctc ctcatgtagg tgttactgct catacaaagt ctgcttctaa gttacagacc
      181 acttccaagg tgcctcagag agccctttct accactgagt ctaagggtct ttctcacaca
      241 agaccatgta aagtagctaa gtacaaaatt aagagaaaac aacaatcttc ccagacctca
      301 ccctctactg agaagtgccc tagaagttct ctcactagca cagtccgcct ggtggtgaac
      361 tacatgatga acatgtgtaa aatgaaaagg cccattctga aagcagatgt gatgaagatg
      421 gtcaccaaca cccataaagt acacatcgct gagatcctca gaagagcttc cttcaacctg
      481 gaggtgttgc tcggtgtaga cttaaaggaa gcagattcta tggattccta tacccttgct
      541 agcaaaatga atctccctaa caatggtgtt ctgactacag gcaggggatt tcccaagact
      601 ggcctgctaa tgaatctcct aggggtgatc ttcctgaaag gaaactgtgc cactgaggaa
      661 agtatctggg aattcctgaa taaaatgaaa atatatgatg gaaagaaaca cttcattttt
      721 ggggaaccca ggaagcttat cactcaagat ttagtgaagc ttaaatacct ggagtatcgg
      781 caagtaccta acagaagtcc tacaagctat gaatttctgt ggggtccaag atctcatgct
      841 gagacaagca agatgaaaat cctgaaattt ttggctaaaa tcaaccatat agttccgagc
      901 gccttccagt cccggtatga tgaggctttg aaagatgagg aggaaagaag tcaagctgca
      961 gctacatttg gtgacacaac aatcaatact aaataa
//
LOCUS       NM_001107573            1586 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus tigger transposable element derived 3 (Tigd3),
            mRNA.
ACCESSION   NM_001107573 XM_001071012 XM_219522
VERSION     NM_001107573.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219522.3, XM_001071012.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1586
                     /gene="Tigd3"
                     /note="tigger transposable element derived 3"
                     /db_xref="GeneID:309174"
                     /db_xref="RGD:1305393"
     exon            1..159
                     /gene="Tigd3"
                     /inference="alignment:Splign:2.1.0"
     exon            160..1586
                     /gene="Tigd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1586
                     /gene="Tigd3"
                     /note="tigger transposable element derived 3 homolog"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 3"
                     /protein_id="NP_001101043.1"
                     /db_xref="GeneID:309174"
                     /db_xref="RGD:1305393"
                     /translation="MELNTKKKLHALSLAEKIQVLELLDESKMSQSEVARRFQVSQPQ
                     ISRICKNKEKLLADWCSGTANHERKRKRESKYSGIDEALLCWYHIARAKAWDVTGPML
                     LHKAKELADIMGQDFVPSIGWLVRWKRRNNVGFGTRQVLVPLLPPEPPPAVSPSQAQP
                     PLSLKDFSPEDVFGCAEVPLLYRAVPGRVFECDRLQVLLCANSRGTEKRRVFVGGLQP
                     APRCFFGVNSEALPASYHPDLAIPWSEWLAQFDQDMGQQGRQVALLLASGVVEEWASP
                     PGLHHVRLLPLSTSSTTPSLPGSVVLAFKAHYRHRLLSKLAAMQSGKEGTSRAEARAN
                     ITVLDALHMVAAAWAKVPRQLILTSFIQEGLAPGKTPLSLDKDTEMSPVPSGLSQEEF
                     SHFVDLEDEDPGPRVCKEETSTEDNGREEDGFESLPTKADALRALCTLRRWLECNSTS
                     PELFEKFYDCEVEVEQLCCL"
     misc_feature    189..344
                     /gene="Tigd3"
                     /note="CENP-B N-terminal DNA-binding domain; Region:
                     CENP-B_N; pfam04218"
                     /db_xref="CDD:461229"
     misc_feature    189..344
                     /gene="Tigd3"
                     /note="CENP-B N-terminal DNA-binding domain; Region:
                     CENP-B_N; pfam04218"
                     /db_xref="CDD:461229"
     misc_feature    399..572
                     /gene="Tigd3"
                     /note="Tc5 transposase DNA-binding domain; Region:
                     HTH_Tnp_Tc5; pfam03221"
                     /db_xref="CDD:460850"
     misc_feature    399..572
                     /gene="Tigd3"
                     /note="Tc5 transposase DNA-binding domain; Region:
                     HTH_Tnp_Tc5; pfam03221"
                     /db_xref="CDD:460850"
     misc_feature    750..1253
                     /gene="Tigd3"
                     /note="DDE superfamily endonuclease; Region: DDE_3;
                     cl46863"
                     /db_xref="CDD:481203"
     misc_feature    750..1253
                     /gene="Tigd3"
                     /note="DDE superfamily endonuclease; Region: DDE_3;
                     cl46863"
                     /db_xref="CDD:481203"
ORIGIN      
        1 cggtggcgcg cgctgggccc tgctttgcgc gcgcccgctc ccgagcagtc cctcggcgcg
       61 ctctgccctc agggtcgcgg cgcccgtccc tctctgattc tgtcaaggcc caggaaccta
      121 gctggggcag ggactggagc cgcgggacgg cacctggagg ctctcaggga gccatggagc
      181 taaacaccaa gaagaagctt cacgccctgt ccctggctga gaaaatccag gttctggaac
      241 tcttggatga gtccaagatg tcccagtcag aggtagcacg gcgcttccag gtctcacagc
      301 cccagatctc acgtatctgc aagaataagg agaagctgtt ggcagactgg tgcagtggca
      361 cagccaacca tgagcggaag cggaagcgtg aatccaaata cagtgggatc gatgaggctc
      421 tactctgctg gtaccacatt gcccgagcca aggcctggga tgtaacaggg cccatgttgc
      481 tccacaaggc caaggaacta gccgatatca tgggccagga tttcgtgccc agcattggct
      541 ggctggtccg ctggaaacgc cgaaacaatg tgggctttgg gactcgccag gtccttgtcc
      601 ctctgctccc tcctgaacct cctcctgcag tttccccctc tcaggcccag ccacctcttt
      661 ctcttaaaga cttctcacca gaagatgttt ttggctgtgc cgaagtaccc ttgttgtatc
      721 gagcagtgcc tggcagagtg tttgaatgtg atcggttgca agtattgctg tgcgccaaca
      781 gcagaggcac agaaaagaga agggtatttg tgggtgggct ccagcctgcc ccaagatgct
      841 tctttggggt caacagtgag gcactgcctg cctcttatca ccctgactta gccattccat
      901 ggtcagagtg gctggcacag ttcgaccagg acatgggaca gcagggccga caggtagcct
      961 tgctgttggc ttctggagtg gtagaggaat gggccagccc tcctggactc caccacgtgc
     1021 gactcctgcc tctctccacc tccagcacca ctccttccct gcctggctct gtggttttgg
     1081 cctttaaggc ccattaccgt caccgtctgc tgagcaaact agctgccatg cagagtggga
     1141 aagagggtac ctcacgtgct gaggccaggg ccaacatcac agttttggat gctctgcata
     1201 tggtggctgc agcttgggcc aaagtacctc gccagctcat tttgaccagc ttcattcaag
     1261 aagggctcgc tccgggcaaa acaccactgt ctctggacaa agatactgag atgtcaccgg
     1321 tccctagtgg gctgagccaa gaggagtttt ctcactttgt ggacctggag gatgaggacc
     1381 cagggcctag agtatgcaaa gaagagacca gtactgaaga caatgggaga gaagaagatg
     1441 gctttgagtc cctgcccacc aaagctgatg ccctgagggc actgtgcacc ttgaggaggt
     1501 ggcttgaatg caacagcacc tctccagaac tcttcgagaa attctatgac tgtgaggtgg
     1561 aggtggagca gctctgctgt ctgtga
//
LOCUS       NM_133291                435 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus seminal vesicle antigen-like 2 (Sval2), mRNA.
ACCESSION   NM_133291
VERSION     NM_133291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Yoshida,M., Kaneko,M., Kurachi,H. and Osawa,M.
  TITLE     Identification of two rodent genes encoding homologues to seminal
            vesicle autoantigen: a gene family including the gene for
            prolactin-inducible protein
  JOURNAL   Biochem Biophys Res Commun 281 (1), 94-100 (2001)
   PUBMED   11178965
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB051831.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051831.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..435
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /note="seminal vesicle antigen-like 2"
                     /db_xref="GeneID:84605"
                     /db_xref="RGD:620869"
     CDS             1..435
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /codon_start=1
                     /product="seminal vesicle antigen-like 2 precursor"
                     /protein_id="NP_579825.1"
                     /db_xref="GeneID:84605"
                     /db_xref="RGD:620869"
                     /translation="MASLQMFYQPRAAMHLLILCLFLETAYGQDIWSNPLSLELIVSP
                     LKKANEFTVTLQVKNNVDQCMAVKVSTVSNPNIKYISSHAIYTSCLCDVNNYFWDIQV
                     IANTALQGKAEVVPAKDICPNDENIFPVTSYIGTATQKIFVS"
     sig_peptide     1..84
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    7..372
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /note="Seminal vesicle autoantigen (SVA); Region: SVA;
                     pfam05326"
                     /db_xref="CDD:398804"
     misc_feature    7..372
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /note="Seminal vesicle autoantigen (SVA); Region: SVA;
                     pfam05326"
                     /db_xref="CDD:398804"
     exon            1..95
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /inference="alignment:Splign:2.1.0"
     exon            96..198
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /inference="alignment:Splign:2.1.0"
     exon            199..310
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /inference="alignment:Splign:2.1.0"
     exon            311..435
                     /gene="Sval2"
                     /gene_synonym="SLP-M"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttctc ttcaaatgtt ctatcagccc agagctgcta tgcatctctt gattttgtgc
       61 ttatttttgg agactgccta tggtcaggac atttggagca atccactttc actagaactg
      121 atagtttctc cactgaaaaa ggcaaacgaa tttacagtaa cactccaggt taaaaataat
      181 gtggaccaat gtatggcggt gaaagtcagt actgtgagca acccaaacat caaatacatt
      241 tcttctcatg ccatttacac ttcctgcctt tgcgatgtaa acaactactt ctgggacatt
      301 caagtcattg ccaatactgc cttacaaggg aaggcagaag ttgttccagc taaggacata
      361 tgtcctaatg atgaaaacat atttccagta acttcctaca tagggactgc tacacaaaaa
      421 atctttgtat catga
//
LOCUS       NM_001002283             987 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAS-related GPR, member B13 (Mrgprb13), mRNA.
ACCESSION   NM_001002283 XM_218594
VERSION     NM_001002283.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY266420.1.
            
            On Apr 19, 2005 this sequence version replaced XM_218594.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..987
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="MAS-related GPR, member B13"
                     /db_xref="GeneID:404643"
                     /db_xref="RGD:738051"
     CDS             1..987
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="MAS-related G protein-coupled receptor, member B8;
                     MAS-related gene B8"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B8"
                     /protein_id="NP_001002283.1"
                     /db_xref="GeneID:404643"
                     /db_xref="RGD:738051"
                     /translation="MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFG
                     LAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIP
                     LLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLL
                     SLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPV
                     TKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCAN
                     PIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQNSIP"
     misc_feature    46..48
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN50.1); glycosylation site"
     misc_feature    91..924
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    91..924
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    100..162
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    187..249
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    190..273
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    190..273
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    337..399
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    430..492
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    430..492
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    433..495
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    535..597
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    559..636
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    559..636
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    673..735
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     misc_feature    775..852
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    775..852
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    790..852
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN50.1);
                     transmembrane region"
     exon            1..987
                     /gene="Mrgprb13"
                     /gene_synonym="MrgB8; Mrgprb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactcaa gcatcccaga cccggaggct gacctcatcc aactgaatgg aagctaccac
       61 acagaaactt caccttgtgt catcgagtcc cgagtcatga ttttgctttc catcatcatt
      121 gccttctttg gcctggcagg aaatgccatg gttctgtggc ttctggcttt ccgcatgcgc
      181 aggaatgtct tctctgtcta catcctcaac ctggctgggg caaacttcct cttcctctgc
      241 actcacactg cattttccct ggaaaagatc attgtccttt ttcactccgt tcacatccac
      301 atcccattgt tgttctacac tctgtccaca cttgcttacc ttgcaggtgt gagcatggtc
      361 acagccatta gtgctgagta ctggttgtct ggcatttggc cctattggta tcagggccag
      421 cgcctaaaac acacaacaac tgtcatttgt actgggctct ggggtttggc cctgctcttg
      481 agcctcctgg aaggaaaaag ttgtggattc ctgggtagta cttataacca agatgtgtgt
      541 tggaaacttg atttcatcat agttgcatgg ttacttgttt tatttgctgt tctttctcga
      601 tccattcaag tcctactggt caggatcttc tgcggttcac agcggactcc tgtgaccaag
      661 ctgcatgtga ccattgtgct cacagcactg gtcttggtga tctgtggctt tcccttcgga
      721 attatcttct acctcttata ctggactaca gaagtttatt atattatgcc ttgtaattct
      781 ttccatgaga caattctcct cctgtcctac attaacagct gtgccaaccc catcatttgc
      841 ttacttgttg gctcaattag gcactgtaga ttccagtgtg ggactctcag gctgctactg
      901 cacagagcca tgcaagatat ccctgaggaa gaaggtgaag aacttgaaga agttgtagga
      961 gaacgagtac agaacagtat accctag
//
LOCUS       NM_023995                927 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 107 (Tas2r107),
            mRNA.
ACCESSION   NM_023995
VERSION     NM_023995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Sekine,H., Takao,K., Yoshinaga,K., Kokubun,S. and Ikeda,M.
  TITLE     Effects of zinc deficiency and supplementation on gene expression
            of bitter taste receptors (TAS2Rs) on the tongue in rats
  JOURNAL   Laryngoscope 122 (11), 2411-2417 (2012)
   PUBMED   23070743
  REMARK    GeneRIF: Gene expression frequency of TAS2R40 and TAS2R107 on the
            tongue significantly decreased in rats fed a zinc-deficient diet,
            and frequency of TAS2R107 significantly increased following zinc
            administration.
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Singh,N., Vrontakis,M., Parkinson,F. and Chelikani,P.
  TITLE     Functional bitter taste receptors are expressed in brain cells
  JOURNAL   Biochem Biophys Res Commun 406 (1), 146-151 (2011)
   PUBMED   21303656
  REMARK    GeneRIF: T2R4 is localized in the neuronal cells of the rat brain
            stem.
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227142.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227142.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..927
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="taste receptor, type 2, member 107"
                     /db_xref="GeneID:78981"
                     /db_xref="RGD:620736"
     CDS             1..927
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="T2R107; taste receptor type 2 member 4; taste
                     receptor T2R4; taste receptor, type 2, member 10"
                     /codon_start=1
                     /product="taste receptor type 2 member 107"
                     /protein_id="NP_076485.1"
                     /db_xref="GeneID:78981"
                     /db_xref="RGD:620736"
                     /translation="MLSAAEGILLCVVTSEAVLGVLGDTFIALANCMEYAKNKKLSKI
                     GFILIGLAISRIGVVWIIILQGYMQVFFPHILTFGNITEYITYIWVFLNHLSVWFATN
                     LNILYFLKIANFSNSVFLWLKSRVRVVFIFLSGCLLTSWLLCFPQFSKMLNNSKMYWG
                     NTSWLQQQKNVFLINQSLTNLGIFFFIIVSLITCFLLIVFLWRHIRQMHSDGSGLRDL
                     NTEAHVKAMRVLISFAVLFILHFVGLSIQVLCFFLPQNNLLFITGLIATCLYPCGHSI
                     ILILGNKQLKQASLKALQHLTCCETKRNLSVT"
     misc_feature    19..870
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    19..870
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..84
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    130..192
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    133..207
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    238..240
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT9.1); glycosylation site"
     misc_feature    247..315
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    283..345
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    382..444
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    391..441
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    391..441
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    457..459
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT9.1); glycosylation site"
     misc_feature    481..483
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT9.1); glycosylation site"
     misc_feature    514..585
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    514..585
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    523..525
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT9.1); glycosylation site"
     misc_feature    541..603
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    658..735
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    658..735
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    697..759
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     misc_feature    769..846
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    769..846
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    775..837
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT9.1);
                     transmembrane region"
     exon            1..927
                     /gene="Tas2r107"
                     /gene_synonym="T2R4; Tas2r10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgagtg cagcagaagg catcctcctt tgtgttgtca ctagtgaggc agtgctgggg
       61 gttttaggag acacattcat tgcacttgca aactgcatgg agtatgccaa gaacaagaag
      121 ctctctaaga ttggtttcat tctcattggc ttggcgattt ccagaattgg tgtcgtatgg
      181 ataataattt tacaggggta tatgcaagta ttttttccac acatacttac ctttggaaac
      241 ataactgaat atattactta catatgggtg tttctcaatc acttaagtgt ctggtttgct
      301 accaacctca atatcctcta ctttctaaag atagcaaatt tttccaactc tgtatttctc
      361 tggctgaaaa gtagagtccg tgtggttttt atctttctgt caggatgctt acttacctcg
      421 tggttactat gttttccaca attttcaaag atgcttaaca acagtaaaat gtactgggga
      481 aacacgtctt ggctccagca gcagaaaaat gtcttcctta ttaaccaaag tttaaccaat
      541 ctgggaatct tctttttcat tattgtatcc ctgattacct gcttcctgtt gattgttttc
      601 ctctggagac acatcaggca aatgcactca gatggttcag gactcagaga cctcaacaca
      661 gaagctcatg tgaaagccat gagagttcta atatcttttg cggtactctt tatcctgcat
      721 ttcgtaggtc tttccataca agtgctatgc ttttttctgc cacaaaacaa cctactcttt
      781 ataactggtt tgatagccac atgcctctat ccctgtggtc actcaatcat cttaattcta
      841 ggaaacaagc agctgaagca agcctccttg aaggcactgc agcacttaac gtgctgtgag
      901 acaaaaagaa atctctcagt cacataa
//
LOCUS       NM_206881               1482 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 1 (Amigo1),
            mRNA.
ACCESSION   NM_206881 XM_227582
VERSION     NM_206881.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Peltola,M.A., Kuja-Panula,J., Liuhanen,J., Voikar,V., Piepponen,P.,
            Hiekkalinna,T., Taira,T., Lauri,S.E., Suvisaari,J., Kulesskaya,N.,
            Paunio,T. and Rauvala,H.
  TITLE     AMIGO-Kv2.1 Potassium Channel Complex Is Associated With
            Schizophrenia-Related Phenotypes
  JOURNAL   Schizophr Bull 42 (1), 191-201 (2016)
   PUBMED   26240432
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Chen,Y., Hor,H.H. and Tang,B.L.
  TITLE     AMIGO is expressed in multiple brain cell types and may regulate
            dendritic growth and neuronal survival
  JOURNAL   J Cell Physiol 227 (5), 2217-2229 (2012)
   PUBMED   21938721
  REMARK    GeneRIF: Data show that AMIGO is a glycosylated protein widely
            expressed in the central nervous system (CNS), and can be found in
            neurons, astrocytes as well as oligodendrocytes.
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Peltola,M.A., Kuja-Panula,J., Lauri,S.E., Taira,T. and Rauvala,H.
  TITLE     AMIGO is an auxiliary subunit of the Kv2.1 potassium channel
  JOURNAL   EMBO Rep 12 (12), 1293-1299 (2011)
   PUBMED   22056818
  REMARK    GeneRIF: AMIGO is a function-modulating auxiliary subunit for
            Kv2.1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY237729.1.
            
            On Apr 5, 2004 this sequence version replaced XM_227582.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY237729.1, BC167749.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1482
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="adhesion molecule with Ig like domain 1"
                     /db_xref="GeneID:295365"
                     /db_xref="RGD:1303079"
     CDS             1..1482
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="amphoterin-induced protein 1; AMIGO-1; alivin-2;
                     amphoretin-induced gene and ORF; transmembrane protein
                     AMIGO"
                     /codon_start=1
                     /product="amphoterin-induced protein 1 precursor"
                     /protein_id="NP_996764.1"
                     /db_xref="GeneID:295365"
                     /db_xref="RGD:1303079"
                     /translation="MQPQRDLRGLWLLLLSLFLLLFEVARAGRPVVSCPANCLCASNI
                     LSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLKAEWTPTRLTNLHSLLLSHNHLNFIS
                     SEAFVPVPNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHIVVVDRNAFEDMAQL
                     QKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKLKKLPLTDLQKLPAWVKNGLYL
                     HNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCVHSKKLHNVFSLDFFNCSEYKES
                     AWEAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVE
                     DGGVYTCYAMGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLY
                     LTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPG
                     QGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV"
     sig_peptide     1..81
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     82..1479
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /product="Amphoterin-induced protein 1.
                     /evidence=ECO:0000255. /id=PRO_0000014508"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1)"
     misc_feature    130..192
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    130..192
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    184..249
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 1"
     misc_feature    193..261
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    193..261
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <196..>672
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <196..>672
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    214..216
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); glycosylation site"
     misc_feature    259..324
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 2"
     misc_feature    262..333
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    262..333
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    331..396
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 3"
     misc_feature    334..405
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    334..405
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    403..468
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 4"
     misc_feature    406..477
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    406..477
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    475..537
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 5"
     misc_feature    478..558
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    478..558
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    556..618
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: LRR 6"
     misc_feature    559..630
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    559..630
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    805..807
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); glycosylation site"
     misc_feature    835..1074
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    835..1074
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    856..870
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    856..870
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    892..906
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    892..906
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    943..945
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); glycosylation site"
     misc_feature    970..984
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    970..984
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1012..1029
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1012..1029
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1045..1047
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); glycosylation site"
     misc_feature    1051..1062
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1051..1062
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1078..1080
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); glycosylation site"
     misc_feature    1117..1179
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     transmembrane region"
     misc_feature    1213..1479
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1429..1431
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); phosphorylation site"
     misc_feature    1441..1443
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80ZD8; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD7.1); phosphorylation site"
     exon            1..1482
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaacccc agcgtgacct gcgaggcctc tggctcctgc tgctctcctt gttcctgctt
       61 ctctttgagg tagctagggc aggccgacct gtggtcagtt gtcccgccaa ttgcctgtgc
      121 gccagcaaca tcctcagctg ctccaagcag cagctaccca atgtgcccca atctttgccg
      181 ggctacacag cgctactgga cctcagccac aacaacttga gccggctgaa ggctgagtgg
      241 acccccaccc gtctgaccaa cctgcactcc ctgctgctga gccacaacca cctgaacttc
      301 atctcctctg aggccttcgt cccggtaccc aaccttcggt acctggacct ctcctccaac
      361 catcttcaca cgctggatga gttcctgttc agcggcctgc aggcactgga agtgctgctg
      421 ctctacaata accacattgt ggtggtggac cggaatgcct tcgaggacat ggcccagctg
      481 cagaaactct acctaagcca gaatatgatc tctcgatttc ctctggaact gatcaaggat
      541 gcaaacagat tacccaaact aacgctcttg gatctgtcct ccaacaagct gaagaagttg
      601 cccctgactg acctgcagaa attgccagcc tgggtcaaga atgggctgta cctgcataac
      661 aaccccctgg agtgtgactg caagctctac cagctctttt cacactggca gtaccggcag
      721 ctgagttctg tgatggactt ccaggaggat ctgtattgcg tgcactccaa gaagctgcat
      781 aacgtcttca gtctggattt cttcaattgc agcgagtaca aggaaagtgc ctgggaggct
      841 cacctgggag acaccttgac catcacgtgc gataccaaac agcaagggat gaccaaagtg
      901 tgggtgaccc caagcaatga gcaggtgcta aaccaggggg ccaatggcac ggtgaccgtg
      961 tccgaggatg gcaaccttca ttttaaagag gtgcaggttg aggatggggg tgtgtatacc
     1021 tgctatgcca tgggggagac tttcaacgaa acactgtctg tggagttgaa agtgtataac
     1081 ttcaccttgc acggacacca tgacaccctc aacacagcct atactaccct ggtgggctgc
     1141 atcctcagtg tggttctggt cctcatatac ttgtacctca caccttgccg ctgctggtgc
     1201 cggggtgtgg agaagccttc cagccatcaa ggagatagcc tcagctcttc tatgctcagt
     1261 accacaccca accatgaccc tatggctggt ggggacaaag atgatggttt tgaccggcgg
     1321 gtggccttcc tggaacctgc tggaccaggg cagggtcaaa atggcaaact caagccaggc
     1381 aacactctgc cggtgcccga ggcaacaggc aagggccaac ggaggatgtc agatccagag
     1441 tcggtcagct cggtcttttc tgatacaccc attgtggtgt ga
//
LOCUS       NM_001025150             960 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 144 (Tas2r144),
            mRNA.
ACCESSION   NM_001025150 XM_575452
VERSION     NM_001025150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Tomas,J., Santos,C.R.A., Duarte,A.C., Maltez,M., Quintela,T.,
            Lemos,M.C. and Goncalves,I.
  TITLE     Bitter taste signaling mediated by Tas2r144 is down-regulated by
            17beta-estradiol and progesterone in the rat choroid plexus
  JOURNAL   Mol Cell Endocrinol 495, 110521 (2019)
   PUBMED   31352039
  REMARK    GeneRIF: the bitter receptors Tas2r109, Tas2r144, and the
            taste-related genes Plcb2 and Trpm5 were down-regulated by ovarian
            hormones
REFERENCE   2  (bases 1 to 960)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362738.1.
            
            On Jul 1, 2005 this sequence version replaced XM_575452.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..960
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="taste receptor, type 2, member 144"
                     /db_xref="GeneID:500101"
                     /db_xref="RGD:1562314"
     CDS             1..960
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="T2R18; T2R40; taste receptor type 2 member 18;
                     taste receptor, type 2, member 40"
                     /codon_start=1
                     /product="taste receptor type 2 member 40"
                     /protein_id="NP_001020321.1"
                     /db_xref="GeneID:500101"
                     /db_xref="RGD:1562314"
                     /translation="MAIITTDSDYYTHRYEVIIPFVVSTIDCIVGIIGNGFITVIYGT
                     ELVRSKRLPTGEHLMLMLSFSRLLLQIWIMVEITYQLFFPMIYNHNAMYKLFKTISVF
                     LNYCNLWFAAWLNVFYCLKIVNFAHPLFLMMKQKIVVLMPRLMSLSVLVSISLSSFFS
                     KDIFNVYMNTSVPIPFSNSTKMKYFFKTNVLNLAFLYYMGIFIPLFMFIMAAILLITS
                     LKRHTLNMESSTTGSRDSSMEAHLGAIKSTSYSLILYIINALALFISMSNIFGAYSTW
                     NSVCSFILTAYPAGQSVHLILRNPGLRRAWRRFQHHVRLYLKR"
     misc_feature    52..921
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="mammalian taste receptor 2, subtype 40, member of
                     the seven-transmembrane G-protein coupled receptor
                     superfamily; Region: 7tm_TAS2R40; cd15014"
                     /db_xref="CDD:320142"
     misc_feature    52..921
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="mammalian taste receptor 2, subtype 40, member of
                     the seven-transmembrane G-protein coupled receptor
                     superfamily; Region: 7tm_TAS2R40; cd15014"
                     /db_xref="CDD:320142"
     misc_feature    52..114
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    55..132
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320142"
     misc_feature    55..132
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320142"
     misc_feature    166..240
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320142"
     misc_feature    166..240
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320142"
     misc_feature    199..261
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    280..348
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320142"
     misc_feature    280..348
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320142"
     misc_feature    295..357
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    409..471
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    427..477
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320142"
     misc_feature    427..477
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320142"
     misc_feature    505..507
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET2.1); glycosylation site"
     misc_feature    532..534
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET2.1); glycosylation site"
     misc_feature    568..639
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320142"
     misc_feature    568..639
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320142"
     misc_feature    586..648
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    712..789
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320142"
     misc_feature    712..789
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320142"
     misc_feature    754..816
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     misc_feature    820..897
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320142"
     misc_feature    820..897
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320142"
     misc_feature    829..891
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET2.1);
                     transmembrane region"
     exon            1..960
                     /gene="Tas2r144"
                     /gene_synonym="RGD1562314; Tas2r40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcaataa taaccacaga ttccgactac tatactcaca ggtatgaagt gataatccct
       61 ttcgtggtct cgaccataga ttgtatcgtc ggcatcattg gcaatggctt catcacagtc
      121 atatatggga ctgaattggt caggagcaaa agactcccca ctggtgagca ccttatgttg
      181 atgttgagtt tttccaggct cttgctacag atctggataa tggtagagat tacctatcaa
      241 ctatttttcc ccatgattta taaccataat gccatgtata aactattcaa aaccatctct
      301 gtgtttctga actactgtaa cctctggttt gccgcgtggc tcaatgtctt ctattgtctt
      361 aaaattgtga actttgctca ccctctgttt cttatgatga agcagaaaat cgtagtgttg
      421 atgcctcggc tcatgagtct gtcagtgttg gtttccatca gcttaagctc cttcttctct
      481 aaagacatct tcaatgtgta tatgaatact tcagttccca tccctttctc caactccaca
      541 aagatgaagt acttctttaa gaccaatgta ctcaacctgg ctttcttata ttatatgggg
      601 atcttcattc ctttgttcat gttcatcatg gcagccattc tgctcatcac ctcactcaag
      661 aggcacaccc tgaacatgga aagcagcacc acaggctcta gggactccag catggaggct
      721 cacttgggtg ccatcaaatc gaccagctac tctctcattc tctacattat caatgcactg
      781 gctctattta tttccatgtc aaatatcttt ggtgcctata gtacctggaa tagtgtgtgc
      841 agctttatcc tgaccgccta tccagctgga cagtcagtgc atctgatctt gagaaaccca
      901 gggctgagaa gagcctggag gcggtttcag caccacgttc gactttacct taaaagatag
//
LOCUS       NM_001002285             945 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAS-related G protein-coupled receptor, member
            X2-like (Mrgprx2l), mRNA.
ACCESSION   NM_001002285 XM_218595
VERSION     NM_001002285.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF518240.1.
            
            On Apr 19, 2005 this sequence version replaced XM_218595.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..945
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="MAS-related G protein-coupled receptor, member
                     X2-like"
                     /db_xref="GeneID:404645"
                     /db_xref="RGD:738053"
     CDS             1..945
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="MAS-related G protein-coupled receptor, member B2;
                     MAS-related gene B2"
                     /codon_start=1
                     /product="MAS-related G protein-coupled receptor, member
                     X2-like"
                     /protein_id="NP_001002285.1"
                     /db_xref="GeneID:404645"
                     /db_xref="RGD:738053"
                     /translation="MSSCGIMSCTMIFLSLIIAIVVLVGNAIVIWLLGFQMCRNAFSI
                     YILNLAGADFLFIGFQIGYCFYIIFDIYTIPIKLPLFFIVMLNFAYLCGLSILSAVSI
                     ERCLCVMRPFWYRCQLPRHTSAVICTMLWVLSLVLSLSEGKECGFLPGTNISDWCKTI
                     DLIITSWLIVLFVVLLVSSLALVITIFCGLYRIPVTRLYVVIVFTVLFFLLFGLPYGI
                     YLFLLVWAETFYYVFPCGFLPVTIFLSCINTCANPIIYFLVGSVRHHRFQRKSLKLLL
                     QQARQDTPETEEYVEMGSLGRSREVNSLQGTESCFDQA"
     misc_feature    25..852
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    25..852
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    31..105
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    31..105
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    127..195
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    127..195
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    244..306
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..306
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    373..423
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    373..423
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    484..555
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    484..555
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    595..663
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    595..663
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    703..780
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    703..780
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..945
                     /gene="Mrgprx2l"
                     /gene_synonym="MrgB2; Mrgprb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcatcat gtggcataat gtcttgtacc atgatatttc tttccctcat cattgctata
       61 gttgttctgg ttggaaatgc catagtgata tggctcctgg gcttccagat gtgcaggaat
      121 gccttctcta tctacatcct caacctggct ggtgctgact ttctcttcat tgggtttcaa
      181 attggatatt gtttttatat tatctttgac atctacacca tcccgattaa attgcctctg
      241 tttttcattg ttatgttaaa ctttgcttat ctttgtggcc tgagcattct cagtgctgtt
      301 agtattgaac gctgcctgtg tgtcatgagg ccattctggt atcgctgcca acttccaagg
      361 catacatcag ctgtcatatg taccatgctt tgggtcttgt ccctagtgtt gagcctttca
      421 gaaggaaaag aatgtggctt cctacctggc actaacatct ctgattggtg taagacaatt
      481 gatttaatca ttacttcatg gctaattgtt ttatttgtgg ttctcttggt gtccagtttg
      541 gccttggtga ttactatctt ctgtggctta tacaggattc ctgtgaccag gctgtatgtg
      601 gtcattgtgt tcacagtgtt gttcttcctg ctctttggtc tgccctatgg gatttatttg
      661 ttcctcttag tgtgggctga gacattttat tatgtttttc cttgtggttt tcttccagtg
      721 acaatatttc tatcctgtat taacacctgt gccaacccca tcatttactt cctcgtaggc
      781 tccgttaggc atcatcggtt tcaacggaag tctctcaagc tacttctgca gcaggccagg
      841 caagacactc ctgagacaga agaatatgta gaaatgggct ccttaggaag atctagagaa
      901 gtaaacagtc tgcaagggac tgagagctgc tttgaccagg cataa
//
LOCUS       NM_001002287             972 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAS-related GPR, member B4 (Mrgprb4), mRNA.
ACCESSION   NM_001002287 XM_579075
VERSION     NM_001002287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 972)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF518242.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579075.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..972
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="MAS-related GPR, member B4"
                     /db_xref="GeneID:404658"
                     /db_xref="RGD:738043"
     CDS             1..972
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="MAS-related G protein-coupled receptor, member B4;
                     MAS-related gene B4"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B4"
                     /protein_id="NP_001002287.1"
                     /db_xref="GeneID:404658"
                     /db_xref="RGD:738043"
                     /translation="MSPTTQAWSINNTVVKENYYTEILSCITTFNTLNFLIVIISVVG
                     MAGNATVLWLLGFHMHRNAFSVYVLNLAGADFLYLCAQTVYSLECVLQFDNSYFYFLL
                     TILMFNYLAGFCMIAAISTERCLSVTWPIWYHCQRPRHTSATVCALFWAFSLLLSLLL
                     GQGCGFLFSKFDYSFCRYCNFIATAFLIVIFMVLFVSSLALLAKIICGSHRIPVTRFY
                     VTIALTVLVFIFFGLPIGICVFLLPWIHMMLSSFFYEMVTLLSCVNSCANPIIYFFVG
                     SIRHHRLQRQTLKLLLQRAMQDTPEEEGGERGPSQKSEDLEVVRCSS"
     misc_feature    31..33
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN45.1); glycosylation site"
     misc_feature    91..900
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    91..900
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    103..165
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    190..270
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    190..270
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    190..252
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    order(253..255,262..267,298..315,319..324,331..333,
                     460..462,466..480,547..549,556..564,568..576,580..585,
                     694..696,703..708,712..717,724..726,748..753,757..765,
                     772..774,781..786)
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..267,298..315,319..324,331..333,
                     460..462,466..480,547..549,556..564,568..576,580..585,
                     694..696,703..708,712..717,724..726,748..753,757..765,
                     772..774,781..786)
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    295..357
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    298..384
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    298..384
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    418..480
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    418..480
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    442..504
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    541..603
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    547..624
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    547..624
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    634..726
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    634..726
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    673..735
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    751..828
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    751..828
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    766..828
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     transmembrane region"
     misc_feature    892..969
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN45.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..972
                     /gene="Mrgprb4"
                     /gene_synonym="MrgB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtccaa ccacccaagc ctggagcatt aacaacacag tagtgaagga aaattactac
       61 actgaaattt tatcctgtat caccacgttc aataccctga attttcttat tgtcatcatt
      121 tctgtggttg gaatggcagg aaatgccaca gtgctgtggc ttctaggctt ccacatgcat
      181 aggaatgcct tctccgtcta tgtcctcaac ctggctggtg ctgatttctt gtacctctgt
      241 gctcagactg tgtactccct ggagtgtgtc cttcagtttg ataacagcta cttttatttt
      301 ctcctcacta tattaatgtt taattacctt gcaggtttct gtatgattgc agccatcagt
      361 actgagcgct gcctatctgt tacgtggccc atctggtatc actgccaaag accaagacac
      421 acatcagcca ccgtgtgtgc tctgttctgg gctttctctc tactgttgag ccttctgtta
      481 gggcaaggct gtggcttcct gtttagtaaa tttgattatt ctttctgtag gtattgtaac
      541 tttatcgcta cggcatttct aatagtaata ttcatggttc tttttgtgtc cagcctagcc
      601 ctcttggcca aaatcatctg tggatcacat aggattcctg tgaccaggtt ctatgtgacc
      661 attgctctca cagtgctggt cttcatattt tttggtctgc ccattgggat ctgcgtgttc
      721 ctcttaccct ggattcatat gatgctctct tccttttttt atgaaatggt aacactcctg
      781 tcctgtgtta acagctgtgc caatcccatc atttacttct ttgttggctc gattagacat
      841 cacaggttac aacggcagac tctgaagcta ctccttcaga gagccatgca ggacactcct
      901 gaggaagagg gtggagagag gggtccttca caaaagtctg aggacctgga agtagtccga
      961 tgcagtagtt aa
//
LOCUS       NM_001037734            5030 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 1 (Trpm1), transcript variant 1, mRNA.
ACCESSION   NM_001037734
VERSION     NM_001037734.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Jirku,M., Lansky,Z., Bednarova,L., Sulc,M., Monincova,L., Majer,P.,
            Vyklicky,L., Vondrasek,J., Teisinger,J. and Bousova,K.
  TITLE     The characterization of a novel S100A1 binding site in the
            N-terminus of TRPM1
  JOURNAL   Int J Biochem Cell Biol 78, 186-193 (2016)
   PUBMED   27435061
  REMARK    GeneRIF: a molecular mechanism for the potential regulation of
            TRPM1 by S100A1
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Devi,S., Markandeya,Y., Maddodi,N., Dhingra,A., Vardi,N.,
            Balijepalli,R.C. and Setaluri,V.
  TITLE     Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium
            channel function and increases melanin content in human melanocytes
  JOURNAL   Pigment Cell Melanoma Res 26 (3), 348-356 (2013)
   PUBMED   23452348
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Thameem,F., Puppala,S., Arar,N.H., Blangero,J., Duggirala,R. and
            Abboud,H.E.
  TITLE     Genetic variants in transient receptor potential cation channel,
            subfamily M 1 (TRPM1) and their risk of albuminuria-related traits
            in Mexican Americans
  JOURNAL   Clin Chim Acta 412 (23-24), 2058-2062 (2011)
   PUBMED   21439949
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Koike,C., Obara,T., Uriu,Y., Numata,T., Sanuki,R., Miyata,K.,
            Koyasu,T., Ueno,S., Funabiki,K., Tani,A., Ueda,H., Kondo,M.,
            Mori,Y., Tachibana,M. and Furukawa,T.
  TITLE     TRPM1 is a component of the retinal ON bipolar cell transduction
            channel in the mGluR6 cascade
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 332-337 (2010)
   PUBMED   19966281
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Morgans,C.W., Zhang,J., Jeffrey,B.G., Nelson,S.M., Burke,N.S.,
            Duvoisin,R.M. and Brown,R.L.
  TITLE     TRPM1 is required for the depolarizing light response in retinal
            ON-bipolar cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (45), 19174-19178 (2009)
   PUBMED   19861548
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Audo,I., Kohl,S., Leroy,B.P., Munier,F.L., Guillonneau,X.,
            Mohand-Said,S., Bujakowska,K., Nandrot,E.F., Lorenz,B.,
            Preising,M., Kellner,U., Renner,A.B., Bernd,A., Antonio,A.,
            Moskova-Doumanova,V., Lancelot,M.E., Poloschek,C.M., Drumare,I.,
            Defoort-Dhellemmes,S., Wissinger,B., Leveillard,T., Hamel,C.P.,
            Schorderet,D.F., De Baere,E., Berger,W., Jacobson,S.G., Zrenner,E.,
            Sahel,J.A., Bhattacharya,S.S. and Zeitz,C.
  TITLE     TRPM1 is mutated in patients with autosomal-recessive complete
            congenital stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 720-729 (2009)
   PUBMED   19896113
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   van Genderen,M.M., Bijveld,M.M., Claassen,Y.B., Florijn,R.J.,
            Pearring,J.N., Meire,F.M., McCall,M.A., Riemslag,F.C., Gregg,R.G.,
            Bergen,A.A. and Kamermans,M.
  TITLE     Mutations in TRPM1 are a common cause of complete congenital
            stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 730-736 (2009)
   PUBMED   19896109
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Li,Z., Sergouniotis,P.I., Michaelides,M., Mackay,D.S., Wright,G.A.,
            Devery,S., Moore,A.T., Holder,G.E., Robson,A.G. and Webster,A.R.
  TITLE     Recessive mutations of the gene TRPM1 abrogate ON bipolar cell
            function and cause complete congenital stationary night blindness
            in humans
  JOURNAL   Am J Hum Genet 85 (5), 711-719 (2009)
   PUBMED   19878917
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Wang,H.P., Pu,X.Y. and Wang,X.H.
  TITLE     Distribution profiles of transient receptor potential
            melastatin-related and vanilloid-related channels in prostatic
            tissue in rat
  JOURNAL   Asian J Androl 9 (5), 634-640 (2007)
   PUBMED   17712480
  REMARK    GeneRIF: Polymerase chain reaction used to check the expression of
            all TRPM and TRPV channel members with specific primers.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ867482.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ867482.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5030
                     /gene="Trpm1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
     exon            1..218
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Trpm1"
                     /note="upstream in-frame stop codon"
     CDS             144..5030
                     /gene="Trpm1"
                     /function="putative ion channel protein"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melastatin; melastatin-1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 1 isoform 1"
                     /protein_id="NP_001032823.1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
                     /translation="MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVI
                     PSTKDPNRCCCGQLTNQHIPPLPSVTPSSTAEDTKQGDAQSGKWSVSKHTQSYPTDSY
                     GILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQP
                     KLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWG
                     MVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQL
                     EKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLREDPPVPVVVCDGSGRASDI
                     LSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSHQLFAIIMECMKKKELVTVFR
                     MGSEGQQDVEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL
                     APPVDTKVAEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQ
                     AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSN
                     LPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDE
                     PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE
                     CMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVA
                     MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIM
                     GILIPPTILFLEFRSYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQ
                     RSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIV
                     SLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQNQPYMGYG
                     RVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQ
                     AILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDRKTRIHIYAMEINPPCGENLYDE
                     EGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRY
                     QLIMTFHDRPVLPPPMIILSHIYIIVMRLSGRCRKKREGDQEERDRGLKLFLSDEELK
                     KLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKASLQ
                     TVDLRLSQLEELSGRMVGALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADG
                     YSMYRYHFNGEELLFEEPALSTSPGTVFRKKTCSFRVKEEDVKPHLDQPSSLHHTPGP
                     SPPATPGRSRLALDGPLSTELRPGLDPGISAGELDPRADFKSAEVAPSLNTANVASTQ
                     LTVESTVSHPLRESKLARYYPGDLNTYKTMKSRSFVYSEGRKLVRGLSNWGAEYSSIM
                     DQTWNSAEWRCQVQRITRSRSTDIPYIVSEAASQDEFEDEHRESLLAPQISRSALTVS
                     DRPEKENLLSVKPHQTLGFPCLRSRSLHGHPRSAKPSPSKLDRAGHASSTSNLAVMSD
                     APEGQNTQQEKGNPETEC"
     misc_feature    144..218
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    336..419
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    489..1286
                     /gene="Trpm1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; pfam18139"
                     /db_xref="CDD:465665"
     misc_feature    489..1286
                     /gene="Trpm1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; pfam18139"
                     /db_xref="CDD:465665"
     misc_feature    1494..1613
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1995..2066
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <2412..3626
                     /gene="Trpm1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    <2412..3626
                     /gene="Trpm1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    2607..2711
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2769..2831
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    2970..3032
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3063..3125
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3162..3224
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3459..3521
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3522..3524
                     /gene="Trpm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q2WEA5.2); glycosylation site"
     misc_feature    3612..3674
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3831..3998
                     /gene="Trpm1"
                     /note="tetramerization domain of TRPM; Region: TRPM_tetra;
                     pfam16519"
                     /db_xref="CDD:465156"
     misc_feature    3831..3998
                     /gene="Trpm1"
                     /note="tetramerization domain of TRPM; Region: TRPM_tetra;
                     pfam16519"
                     /db_xref="CDD:465156"
     misc_feature    4221..4379
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4860..5027
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            219..298
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..494
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..708
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..833
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1005
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1180
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1304
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1377
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1478
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1649
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1784
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1835
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1976
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2006
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2299
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2528
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2651
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2783
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2912
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3164
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3357
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3378
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3523
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3726
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3859
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..5030
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttctgag ctgactgagc caccaatatc acccccgaac tctgagccct gctgtccagc
       61 ctggtaaaga gaactctctt gcctcagcct attggagact cccatgcagc aggctgggcc
      121 tcacagggaa tgcagaagca ccaatggggt ccatgaggaa aatgagcagc tccttcaagc
      181 gtggttcaat caagagctcc acatcagggt cccagaaggg tcagaaagca tggatagaga
      241 agacgttttg caaaagggaa tgcatcttcg tgattcctag tacaaaagac ccgaacagat
      301 gttgctgtgg tcagctcact aaccagcaca tccccccgct gccgagtgtg actcccagct
      361 caacagcaga ggacaccaag caaggggacg cacagtccgg gaaatggtct gtcagcaaac
      421 acacccagag ctacccaaca gactcctatg ggattcttga attccagggt gggggctact
      481 ccaataaagc catgtatatc cgagtctcct acgacaccaa gccagattct ctgctccatc
      541 tcatggtgaa ggactggcag ctggagctcc ccaagctctt gatatctgtg catggaggcc
      601 tccagagctt tgagatgcag cccaagctga agcaggtctt tgggaaaggt ctgatcaagg
      661 ctgccatgac cacaggggca tggatcttca ccgggggagt gagcactggt gtcgtcagcc
      721 atgtggggga tgccttgaag gaccactcct ccaagtccag aggccggctc tgtgctatcg
      781 gaatcgctcc ctggggcatg gtggagaaca aggaagatct ggttgggaaa gatgtaacga
      841 gagtctacca gaccatgtcc aaccctctga gcaagctctc cgtgctcaac aattctcaca
      901 ctcacttcat cttggctgac aatggcaccc ttggcaagta tggtgccgag gtgaagcttc
      961 gaagacaact ggaaaaacac atctccctgc agaagatcaa cacgaggctg ggccagggtg
     1021 tacctgtcgt gggtctcgtg gtggaaggtg gacctaatgt ggtttctatc gtcctggagt
     1081 atctcagaga agaccctcct gtccctgtgg tggtttgtga cggcagtgga cgcgcctccg
     1141 acattttgtc ttttgcacac aaatactgcg acgaaggagg ggtcataaac gagtccctgc
     1201 gggaccagct tctagttacc attcagaaaa catttaatta cagcaagtcc cagtcgcatc
     1261 agctgtttgc aattatcatg gagtgcatga agaagaaaga actcgtcact gtgtttcgga
     1321 tgggctctga gggtcagcaa gatgttgaga tggcaatttt aactgccttg ctcaaaggaa
     1381 ccaacgtgtc agctccagat cagctgagct tggcactggc ttggaaccgc gtggacatag
     1441 cacgaagcca gatcttcgtc tttggcccac actggccgcc actgggaagc ctggcccctc
     1501 ctgtggacac caaagtcgca gagaaggaga agaagccacc cacagccacc accaagggaa
     1561 gaggaaaagg gaaaggcaag aagaaaggca aagtgaaaga ggaggtggag gaagaaacag
     1621 acccccggaa gatcgagctg ctgaactggg tgaacgccct ggagcaagcc atgctggacg
     1681 ctcttgtctt agaccgggtt gactttgtga agctcctgat tgaaaacgga gtgaacatgc
     1741 agcatttcct cactatcccg aggctggagg agctttacaa cactagactg ggcccaccaa
     1801 acacccttca tctgctggtg cgggatgtga agaagagcaa ccttccacct gactaccaca
     1861 tcagcctcat cgatatagga ctggtgttgg agtacctcat gggaggtgcc taccgctgca
     1921 actacactcg gaaaagcttc cggactctct acaacaactt gtttggccct aagaggccaa
     1981 aagcacttaa actcctggga atggaagatg atgagccccc agccaagggg aagaagaaaa
     2041 agaagaagaa gaaagaggag gagattgata tagatgtgga cgaccccgct gtgagtcggt
     2101 tccagtatcc gttccacgag ctcatggtat gggccgtgct catgaagcgc cagaagatgg
     2161 cagtcttcct gtggcagcgt ggggaggagt gcatggcaaa ggccttggtg gcctgtaagc
     2221 tctacaaggc catggcccac gagtcctcgg agagcgagct ggtggatgac atctcccagg
     2281 atctggacaa caattccaag gattttggcc agctcgctgt ggagctgtta gaccagtctt
     2341 acaagcacga tgagcaagtg gccatgaaac ttctgaccta tgagctcaag aactggagca
     2401 actcgacctg ccttaagctg gccgtggcgg ccaagcacag ggactttatc gctcacacct
     2461 gcagccagat gctgctgaca gacatgtgga tgggaaggct tcgcatgagg aagaaccctg
     2521 gcctgaaggt catcatgggg atccttatcc cgcccaccat cttgtttttg gaattccgtt
     2581 catatgatga cttctcctat caaacatcca aggagaatga agatggcaaa gaaaaggaag
     2641 aagagaatgt ggatgcaaat gcagatgctg gctcaagaaa gggggatgag gagaatgagc
     2701 acaaaaaaca gaggagcatt cccattggaa caaagatctg tgaattctat aatgcgccca
     2761 ttgtcaagtt ctggttttac acaatctcct acttgggcta cttgctgctg ttcaattatg
     2821 tcatcctggt gcggatggac ggctggcctt caccccaaga atggatcgtt atctcctaca
     2881 ttgtgagcct ggcactagag aaaatacgag agatcctcat gtcggaacca ggcaaactca
     2941 gccagaaaat caaagtgtgg ctccaagagt actggaacat cacagacctt gtggccattt
     3001 ccatgttcat ggttggggcc atccttcgcc tccagaacca gccatacatg ggctatggcc
     3061 gggtcatcta ctgtgtggat atcatcctct ggtacatccg agtgttagac atctttggtg
     3121 tcaacaagta tcttggcccc tatgtaatga tgattggaaa gatgatgatt gacatgctgt
     3181 actttgtggt cattatgctg gttgtgctga tgagtttcgg cgtagctcgg caagccatct
     3241 tgcacccaga ggagaagcct tcttggaaac tggcccgaaa catcttctac atgccctact
     3301 ggatgatcta cggagaagtg tttgcagacc agatagaccg taagactaga attcatatct
     3361 atgccatgga aatcaaccct ccttgtggtg aaaatctcta tgatgaggaa ggcaagaggc
     3421 tccctccctg catccctggt gcctggctca cacctgccct catggcctgt tatctcctgg
     3481 tggccaatat cctgctggtc aacctgctga ttgctgtttt caacaatacc ttctttgaag
     3541 tcaagtcaat atccaatcaa gtgtggaagt tccagcggta ccaactgatc atgacatttc
     3601 acgacaggcc ggtcctgccc ccgccaatga tcatcttaag ccacatctac atcatcgtta
     3661 tgcgtctcag tggtcgctgc agaaaaaaga gagaagggga ccaggaggag cgggatcgtg
     3721 ggttgaagct gttcctcagc gacgaggaac tgaaaaaact gcatgagttt gaggagcagt
     3781 gcgtgcagga gcacttccga gaaaaggagg atgagcagca gtcgtccagc gatgagcgca
     3841 tccgggttac aagcgagaga gttgaaaata tgtcaatgag gctggaggaa atcaacgaaa
     3901 gagaaaattt catgaaggcg tctctgcaga ctgtcgacct tcggctctct cagctggagg
     3961 agctatctgg caggatggtg ggcgctctgg agaatctggc aggcatcgac aggtctgatc
     4021 tgatccaggc tcgatcaaga gcatcctcag aatgtgaggc cacctacctg ctgcggcaga
     4081 gcagtatcaa cagcgccgat ggctacagca tgtaccgcta ccatttcaat ggcgaggagc
     4141 ttctgtttga ggagcccgcc ctctccactt cgccagggac agtgttccgg aaaaaaacct
     4201 gctccttccg cgtgaaggaa gaggatgtaa aaccacacct ggaccagcca agtagcctgc
     4261 accacacccc aggccccagc ccgcctgcca cgccaggtcg cagccggctt gcccttgatg
     4321 gtcccttgag cacagagttg agacctggac tggatcctgg tatctctgcg ggtgagcttg
     4381 atccgcgggc agatttcaag agcgccgaag ttgcaccaag tctgaacacg gcgaatgttg
     4441 caagcactca gctgaccgtc gaaagcactg tttcccaccc actgcgggag agcaaactcg
     4501 cgcgctacta ccccggagac ctcaacacct acaaaacaat gaagtccaga agcttcgtct
     4561 attctgaagg aagaaaactt gtccgaggtc ttagcaactg gggtgccgag tacagttcaa
     4621 tcatggacca aacatggaac tcggcagaat ggagatgtca agttcaaagg atcacacgct
     4681 cccgcagcac agacatcccg tacattgtgt ctgaagcagc ctcccaagat gagtttgagg
     4741 atgagcacag agaatctctt ctggctcctc agatctcccg ttcagccctc acggtctctg
     4801 acaggcccga aaaggaaaac ttgctgtctg tgaagccaca ccagacttta ggattcccct
     4861 gcctacggtc aagaagttta catggtcatc ctaggagtgc caaaccctct cctagcaaat
     4921 tagacagggc gggacatgcc agcagcacca gcaacttagc agttatgtca gacgctccag
     4981 agggacaaaa cacccagcag gagaaaggaa acccggaaac tgaatgctaa
//
LOCUS       NM_001002833            1428 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Sumo1/sentrin/SMT3 specific peptidase 17
            (Senp17), mRNA.
ACCESSION   NM_001002833 XM_579093
VERSION     NM_001002833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Kamitani,T., Kito,K., Nguyen,H.P., Wada,H., Fukuda-Kamitani,T. and
            Yeh,E.T.
  TITLE     Identification of three major sentrinization sites in PML
  JOURNAL   J Biol Chem 273 (41), 26675-26682 (1998)
   PUBMED   9756909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000370.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579093.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BN000370.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1428
                     /gene="Senp17"
                     /note="Sumo1/sentrin/SMT3 specific peptidase 17"
                     /db_xref="GeneID:408216"
                     /db_xref="RGD:1303080"
     CDS             1..1428
                     /gene="Senp17"
                     /function="SUMO cysteine protease"
                     /note="Sumo1/sentrin/Smt3 specific protease 17; sentrin
                     17"
                     /codon_start=1
                     /product="Sumo1/sentrin/SMT3 specific peptidase 17"
                     /protein_id="NP_001002833.1"
                     /db_xref="GeneID:408216"
                     /db_xref="RGD:1303080"
                     /translation="MWQPKQPGVGMKPEASEQRRKRKHLDQSGTETESEALGQGPSWN
                     CQGGTQMVFQKPGKARKKTRQEHQDQKLKKEQPGKGQGQKTQEEGSGNIKPLECQPDQ
                     TVVEKLAEGGKCRKRQYSVLQEKPQSPQNEKHARSLEHLQGGHPVRSDPHRPHPTFSD
                     TSNNKGGMPGHPHGRETAHGDRQPSTEVLSTKREKRCAEEKCVRGNSLEHGLRGTENA
                     NILDSGGGRLLPDKVAVVAGEKNALPEQENNQEKEFTKEMEKEVEKALGPGAQEEILS
                     TGFKLKITRGDMQTLKNGQWPNDEIINFYMNLLVQRNENQGYPALHAFSTFFYAKLKH
                     GGYNSVKRWTRGINLFEKELILVPIHQRVHWSLVVIDLRKRSIVYLDSMGQTGKNICE
                     TIFHYLQNESKTRRNMELDPVEWKQYSLTSQEIPQQLNGSDCGMFTCKYADYISRDQP
                     VTFSQQHMPLFRRRMVWEILHSHLL"
     misc_feature    <730..1410
                     /gene="Senp17"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     Region: Peptidase_C48; cl23802"
                     /db_xref="CDD:420019"
     misc_feature    <730..1410
                     /gene="Senp17"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     Region: Peptidase_C48; cl23802"
                     /db_xref="CDD:420019"
     exon            1..1428
                     /gene="Senp17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggcaac ctaaacagcc cggagtgggc atgaaacccg aagcttcaga acaacgtcga
       61 aagcggaaac acctcgacca aagtgggaca gagaccgagt ctgaagcttt gggacaaggt
      121 ccatcatgga actgccaagg tggaacacaa atggtgtttc agaagcctgg aaaggctcgg
      181 aagaagaccc gtcaggagca tcaagaccaa aaacttaaaa aagaacagcc cggcaagggt
      241 cagggacaga aaacccagga agagggttca ggaaatatca aacccctaga gtgtcagcca
      301 gatcagactg tagttgagaa gttggctgag ggtggcaagt gtcgtaagcg gcaatattct
      361 gtcctacagg aaaaacctca aagcccccaa aacgaaaagc atgctaggtc actcgaacat
      421 cttcaaggtg gccatcctgt gaggtctgac ccacacaggc ctcacccaac cttttctgac
      481 acctccaaca acaaaggtgg aatgccaggg catcctcatg gacgagaaac agctcacgga
      541 gatagacagc catcgacaga ggttctctct accaagagag aaaagaggtg tgctgaggag
      601 aaatgtgtac gggggaacag cttggagcat ggcttgcggg gaacagagaa tgcaaacatc
      661 ctggacagtg gcggcggtag gttactcccc gacaaggtgg cagtagttgc aggagagaaa
      721 aatgctctcc cagagcaaga aaacaaccaa gaaaaagaat ttacaaaaga aatggaaaag
      781 gaagttgaga aagcattggg tccaggagcc caggaagaaa tcctcagtac gggattcaag
      841 ctcaaaatca cacgaggaga tatgcagacc ctcaagaacg gtcagtggcc caatgatgag
      901 atcatcaatt tctacatgaa tcttctggtt cagagaaatg aaaaccaagg ctaccctgct
      961 cttcatgcct ttagcacttt cttttacgcc aagctaaagc atggcggtta caattctgtg
     1021 aaaagatgga cccgaggaat caatctcttt gaaaaagaac ttatcttggt gcctattcac
     1081 cagagggtcc attggagcct ggtggtaatc gatttaagaa agcgaagcat tgtctacctc
     1141 gattcaatgg gtcagacagg gaaaaatatc tgtgagacca tcttccacta tttacaaaat
     1201 gagagcaaga cccgaaggaa catggagctg gaccctgtgg agtggaagca gtacagctta
     1261 acttcacagg agatccctca acaactgaat gggagcgact gtgggatgtt cacctgcaaa
     1321 tatgcagatt acatctctag agaccaacct gtgacctttt ctcagcaaca catgcccctc
     1381 ttcaggagga ggatggtgtg ggaaatcctg cacagtcact tactgtaa
//
LOCUS       NM_001080937             888 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 120 (Tas2r120),
            mRNA.
ACCESSION   NM_001080937 XM_001074477
VERSION     NM_001080937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362737.1.
            
            On Jan 31, 2007 this sequence version replaced XM_001074477.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..888
                     /gene="Tas2r120"
                     /note="taste receptor, type 2, member 120"
                     /db_xref="GeneID:690448"
                     /db_xref="RGD:1596060"
     CDS             1..888
                     /gene="Tas2r120"
                     /note="putative taste receptor T2R17; T2R120; taste
                     receptor type 2 member 17"
                     /codon_start=1
                     /product="taste receptor type 2 member 120"
                     /protein_id="NP_001074406.1"
                     /db_xref="GeneID:690448"
                     /db_xref="RGD:1596060"
                     /translation="MDLTEWIVTIIMMIEFLLGNCANFFIMVVNAIDCMKRRKISSAD
                     RIITALAISRIGLLWAMLMNWHSRVYTTDTYSFQVTAFSGIIWAITNHFTTWLGTILS
                     MFYLFKIANFSNCLFLHLKRKLDSVLLVIFLVSSLLVFAYLGVVNIKKIAWLSVHEGN
                     VTVKSKLMNIASIRDTLLFSLINIAPFGISLTCVLLLIYSLGKHLKNMKFYGKGCQDQ
                     STMVHIRALQTVVSFLLLYATYSSCVIISGWSIQNVPIFLFCVTIGAFYPAGHSCILI
                     WGNQKLKQFLLLFLRQMKC"
     misc_feature    7..837
                     /gene="Tas2r120"
                     /note="mammalian taste receptor 2, subtype 43, and related
                     proteins, member of the seven-transmembrane G
                     protein-coupled receptor superfamily; Region:
                     7tm_TAS2R43-like; cd15027"
                     /db_xref="CDD:320155"
     misc_feature    7..837
                     /gene="Tas2r120"
                     /note="mammalian taste receptor 2, subtype 43, and related
                     proteins, member of the seven-transmembrane G
                     protein-coupled receptor superfamily; Region:
                     7tm_TAS2R43-like; cd15027"
                     /db_xref="CDD:320155"
     misc_feature    16..78
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    19..96
                     /gene="Tas2r120"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320155"
     misc_feature    19..96
                     /gene="Tas2r120"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320155"
     misc_feature    130..204
                     /gene="Tas2r120"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320155"
     misc_feature    130..204
                     /gene="Tas2r120"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320155"
     misc_feature    136..198
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    241..309
                     /gene="Tas2r120"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320155"
     misc_feature    241..309
                     /gene="Tas2r120"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320155"
     misc_feature    250..312
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    376..438
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    388..438
                     /gene="Tas2r120"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320155"
     misc_feature    388..438
                     /gene="Tas2r120"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320155"
     misc_feature    478..480
                     /gene="Tas2r120"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET3.1); glycosylation site"
     misc_feature    514..585
                     /gene="Tas2r120"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320155"
     misc_feature    514..585
                     /gene="Tas2r120"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320155"
     misc_feature    532..594
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    658..735
                     /gene="Tas2r120"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320155"
     misc_feature    658..735
                     /gene="Tas2r120"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320155"
     misc_feature    691..753
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     misc_feature    760..837
                     /gene="Tas2r120"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320155"
     misc_feature    760..837
                     /gene="Tas2r120"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320155"
     misc_feature    766..828
                     /gene="Tas2r120"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET3.1);
                     transmembrane region"
     exon            1..888
                     /gene="Tas2r120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatttga cagaatggat cgtcactatc ataatgatga tagaatttct cttaggaaac
       61 tgtgctaatt tcttcataat ggtagtgaac gccattgact gtatgaagag aagaaagatc
      121 tcctcagccg atcgaattat aactgctctt gccatctcca gaattggttt gttatgggca
      181 atgttaatga actggcattc acgtgtgtat actacagata cgtacagttt tcaagtgaca
      241 gcttttagtg gaattatctg ggcgataact aatcatttta ccacttggct tgggaccata
      301 ctcagcatgt tttatttatt caagatagcc aacttttcca attgtctatt tcttcatctg
      361 aaaagaaaac ttgacagtgt tcttcttgtg atatttttgg tgtcttcttt gcttgtgttt
      421 gcataccttg gggtagtgaa catcaagaag attgcttggt tgagtgttca tgaaggaaat
      481 gtgacggtaa agagcaaact gatgaatata gcaagcatta gagatacgct tctcttcagc
      541 ctgataaaca tcgcaccatt tggtatatca ctgacctgtg ttctgctctt aatctactcc
      601 ctaggcaaac atctcaagaa tatgaaattc tatggcaaag gatgtcaaga tcagagtacc
      661 atggtccaca taagggcctt gcaaactgtg gtttcctttc tcttgttata tgctacatac
      721 tcttcctgtg taattatatc aggttggagt atacaaaatg tgccaatctt cttattttgt
      781 gtgacaattg gtgccttcta cccagcaggt cattcttgta tcttgatttg gggaaaccag
      841 aagcttaaac agttccttct gttgtttctg aggcagatga aatgctga
//
LOCUS       NM_175585               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 7a (Taar7a),
            mRNA.
ACCESSION   NM_175585
VERSION     NM_175585.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Shows that expression of Taar family members is limited to
            specific tissue subpopulations and developmental stages in mouse.
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380196.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="trace amine-associated receptor 7a"
                     /db_xref="GeneID:294125"
                     /db_xref="RGD:631387"
     CDS             1..1077
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="taR-8; taR-7a; trace amine receptor 7a; trace amine
                     receptor 8"
                     /codon_start=1
                     /product="trace amine-associated receptor 7a"
                     /protein_id="NP_783175.1"
                     /db_xref="GeneID:294125"
                     /db_xref="RGD:631387"
                     /translation="MDKLVDNFLSGQSRTMSEDLLSASSPQLCYENLNGSCIRSPYSP
                     GPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMP
                     FSTVRSVEGCWYFGDTYCKFHSCFEGSFCYSSIFHLCFISVDRYIAVSDPLIYPTRFT
                     ASVSGKCITFSWLLSIIYSFSLLYTGANEAGLEDLVSALTCVGGCQIAVNQSWVFINF
                     LLFLVPTLVMMTVYSKIFLIAKQQAQNIEKMSKQTTRASESYKDRVAKRERKAAKTLG
                     IAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFR
                     KAIKLIVTGKILRQNSSVTNLFPE"
     misc_feature    100..102
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y2.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    148..222
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    247..315
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    247..315
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    250..312
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    361..429
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    364..429
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    496..546
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    499..561
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    628..699
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    628..630
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y2.1); glycosylation site"
     misc_feature    637..699
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    814..882
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    823..885
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    913..990
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    928..999
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y2.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7a"
                     /gene_synonym="Ta8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacaagt tggttgacaa tttcctcagt ggtcaatcta gaaccatgag tgaagatctc
       61 ctctcagctt cctctcccca gctgtgctat gagaacctga atggatcctg catcaggagc
      121 ccatactccc caggccctcg cctcatcctc tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tcttggtggg tctgactgtg
      301 atgcccttta gcacggtgag gtctgtggag ggctgctggt actttgggga cacttattgt
      361 aaattccatt cttgttttga agggtcattc tgctattctt ctatattcca cttgtgtttc
      421 atctctgttg atagatacat tgcagtcagt gaccccctga tctaccccac caggttcact
      481 gcatctgttt ctggcaagtg catcaccttc tcctggctcc tgtccatcat ctacagcttt
      541 tctctccttt acacaggggc caatgaagct gggctggagg atctagtgag tgctctcacc
      601 tgtgtgggtg gatgtcaaat cgcagtgaat caaagctggg tcttcatcaa tttcctattg
      661 tttcttgtcc ccacgcttgt gatgatgact gtctactcta agatcttcct cattgcaaag
      721 cagcaggctc agaacatcga gaaaatgagc aaacagacca ccagggcctc tgaaagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccctgggcat cgcagtggct
      841 gccttcctcc tttcatggct gccatatttc attgactcaa tcattgatgc cttcctgggg
      901 ttcatcacgc ccacgtatgt gtatgaaatc ctagtttgga tagcttacta taactcagcc
      961 atgaaccctt tgatttatgc tttcttttat ccctggtttc gaaaagccat caaactcatt
     1021 gtcactggca aaatcttgag acagaattcc tcagtcacca acctgtttcc tgaatag
//
LOCUS       NM_023999                930 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 105 (Tas2r105),
            mRNA.
ACCESSION   NM_023999
VERSION     NM_023999.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227146.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227146.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..930
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="taste receptor, type 2, member 105"
                     /db_xref="GeneID:78985"
                     /db_xref="RGD:620741"
     CDS             1..930
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="T2R105; taste receptor type 2 member 9; taste
                     receptor T2R9"
                     /codon_start=1
                     /product="taste receptor type 2 member 105"
                     /protein_id="NP_076489.1"
                     /db_xref="GeneID:78985"
                     /db_xref="RGD:620741"
                     /translation="MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNKKLSKI
                     GFLLFGLATSRIFIVWILILDAYAKLFFPGKYLSKSLTEIISCIWMTVNHMTVWFATS
                     LSIFYFLKIANFSHYIFLWLKRRTDKVFAFLLWCLLISWAISFSFTVKVMKSNPKNHG
                     NRTSGTHWEKREFTSNYVLINIGVISLLIMTLTACFLLIISLWKHSRQMQSNVSGFRD
                     LNTEAHVKAIKFLISFIILFILYFIGVAVEIICMFIPENKLLFIFGLTTASVYPCCHS
                     VILILTNSQLKQAFVKVLEGLKFSENGKDLRAT"
     misc_feature    19..873
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    19..873
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    28..96
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    133..207
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    133..201
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    247..315
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    259..327
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    388..447
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    391..441
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    391..441
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    481..483
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT5.1); glycosylation site"
     misc_feature    517..588
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    517..588
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    532..600
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    661..738
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    661..738
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    679..747
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     misc_feature    772..849
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    772..849
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    775..843
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT5.1);
                     transmembrane region"
     exon            1..930
                     /gene="Tas2r105"
                     /gene_synonym="T2R9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcagtg cagcagaagg catccttctt tccattgcaa ctgttgaagc tgggctggga
       61 gttttaggga acacatttat cgccctggtt aactgcatgg attgggccaa gaacaagaag
      121 ctctctaaga ttggtttcct tctctttggc ttagcaactt ccagaatttt tattgtatgg
      181 atattaattt tagacgcata tgcaaagcta ttctttccgg ggaagtattt gtctaagagt
      241 ctgactgaaa tcatctcttg tatatggatg actgtgaatc acatgactgt ctggtttgcc
      301 accagcctca gcatcttcta tttcctaaaa atagcaaatt tttcccacta tatatttctc
      361 tggttaaaga ggagaactga taaagtattt gcctttctct tgtggtgttt attaatttca
      421 tgggcaatct ccttctcatt cactgtgaaa gtgatgaaga gcaatccaaa gaatcatgga
      481 aacaggacca gtgggacaca ttgggagaag agagaattca caagtaacta tgttttaatc
      541 aatattggag tcatttctct cttgatcatg accttaactg catgtttctt gttaattatt
      601 tcactttgga aacacagcag gcagatgcag tctaatgttt caggattcag agatctcaac
      661 actgaagctc atgtgaaagc cataaaattt ttaatttcat ttatcatcct tttcatcttg
      721 tactttatag gtgttgcagt agaaatcatc tgcatgttta tcccagaaaa caaactgcta
      781 tttatttttg gtttgacaac tgcatccgtc tatccctgct gtcactcagt cattctaatt
      841 ctaacaaaca gccagctgaa gcaagccttt gtaaaggtac tggagggatt aaagttctct
      901 gagaacggaa aagatctcag ggccacatga
//
LOCUS       NM_001109474             693 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin associated protein 5-8 (Krtap5-8), mRNA.
ACCESSION   NM_001109474 XM_001064244
VERSION     NM_001109474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH473953.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001064244.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..693
                     /gene="Krtap5-8"
                     /note="keratin associated protein 5-8"
                     /db_xref="GeneID:685544"
                     /db_xref="RGD:1592604"
     CDS             1..693
                     /gene="Krtap5-8"
                     /codon_start=1
                     /product="uncharacterized protein LOC685544"
                     /protein_id="NP_001102944.1"
                     /db_xref="GeneID:685544"
                     /db_xref="RGD:1592604"
                     /translation="MTCCGCSGGCGSSCGGCGSSCGGCGSSCGGCGSCCGGCGSCCCK
                     PVCCCVPVCSCSSCGGCKGGCGSCGGCSSCGGCKGGCGSCGGCKGGCGSCGGCKGGCG
                     SCGGCKGGCGSCGGCSSCGGCKGGCGSCGGCKGGCGSCGGCKGGCGSCGGCKGGCCQS
                     SCCKPCCCQSSCCKPCCSSGCGSSCCQSSCCKPCCCQSSCCKPCCCQSSCCKPCCCQS
                     SCCAPVCCQCKI"
     exon            1..693
                     /gene="Krtap5-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacctgct gtggctgctc aggaggctgt ggctccagct gtgggggctg tggctccagc
       61 tgtgggggct gtggctccag ctgtgggggc tgtggctcct gctgtggggg ctgtggctcc
      121 tgctgctgca agcctgtgtg ctgctgtgtg cctgtctgtt cctgctccag ctgtgggggc
      181 tgcaagggag gctgtggctc ctgtgggggc tgtagttcct gtggaggctg caagggaggc
      241 tgtggctcct gtgggggctg caagggaggc tgtggctcct gtgggggctg caagggaggc
      301 tgtggctcct gtgggggctg caagggaggc tgtggctcct gtgggggctg cagctcctgt
      361 gggggctgca agggaggctg tggctcctgt gggggctgca agggaggctg tggctcttgt
      421 gggggctgca agggaggctg tggttcctgt ggtggctgta agggaggctg ctgtcagtcc
      481 agctgctgca aaccctgctg ctgccagtcc agctgttgca agccttgctg ctcttcaggt
      541 tgtgggtctt cctgttgcca atccagctgc tgcaagccct gctgctgtca gtccagctgt
      601 tgtaagccat gctgctgtca gtccagctgc tgtaagccct gctgctgtca gtccagctgt
      661 tgtgcccctg tgtgctgcca atgtaagatc tga
//
LOCUS       NM_001024238            4461 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus glutamyl-prolyl-tRNA synthetase 1 (Eprs1),
            transcript variant 1, mRNA.
ACCESSION   NM_001024238 XM_213969
VERSION     NM_001024238.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   Arif,A., Terenzi,F., Potdar,A.A., Jia,J., Sacks,J., China,A.,
            Halawani,D., Vasu,K., Li,X., Brown,J.M., Chen,J., Kozma,S.C.,
            Thomas,G. and Fox,P.L.
  TITLE     EPRS is a critical mTORC1-S6K1 effector that influences adiposity
            in mice
  JOURNAL   Nature 542 (7641), 357-361 (2017)
   PUBMED   28178239
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Forster,F., Paster,W., Supper,V., Schatzlmaier,P., Sunzenauer,S.,
            Ostler,N., Saliba,A., Eckerstorfer,P., Britzen-Laurent,N.,
            Schutz,G., Schmid,J.A., Zlabinger,G.J., Naschberger,E., Sturzl,M.
            and Stockinger,H.
  TITLE     Guanylate binding protein 1-mediated interaction of T cell antigen
            receptor signaling with the cytoskeleton
  JOURNAL   J Immunol 192 (2), 771-781 (2014)
   PUBMED   24337748
REFERENCE   3  (bases 1 to 4461)
  AUTHORS   Son,J., Lee,E.H., Park,M., Kim,J.H., Kim,J., Kim,S., Jeon,Y.H. and
            Hwang,K.Y.
  TITLE     Conformational changes in human prolyl-tRNA synthetase upon binding
            of the substrates proline and ATP and the inhibitor halofuginone
  JOURNAL   Acta Crystallogr D Biol Crystallogr 69 (Pt 10), 2136-2145 (2013)
   PUBMED   24100331
REFERENCE   4  (bases 1 to 4461)
  AUTHORS   Zhou,H., Sun,L., Yang,X.L. and Schimmel,P.
  TITLE     ATP-directed capture of bioactive herbal-based medicine on human
            tRNA synthetase
  JOURNAL   Nature 494 (7435), 121-124 (2013)
   PUBMED   23263184
REFERENCE   5  (bases 1 to 4461)
  AUTHORS   Arif,A., Chatterjee,P., Moodt,R.A. and Fox,P.L.
  TITLE     Heterotrimeric GAIT complex drives transcript-selective translation
            inhibition in murine macrophages
  JOURNAL   Mol Cell Biol 32 (24), 5046-5055 (2012)
   PUBMED   23071094
REFERENCE   6  (bases 1 to 4461)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Le Marechal,P.,
            Negrutskii,B. and Mirande,M.
  TITLE     Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the
            Cytoplasm of Human Cells
  JOURNAL   J Biol Chem 284 (20), 13746-13754 (2009)
   PUBMED   19289464
REFERENCE   7  (bases 1 to 4461)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Gillet,S., Le
            Marechal,P., Negrutskii,B. and Mirande,M.
  TITLE     Dissection of the structural organization of the aminoacyl-tRNA
            synthetase complex
  JOURNAL   J Biol Chem 284 (10), 6053-6060 (2009)
   PUBMED   19131329
REFERENCE   8  (bases 1 to 4461)
  AUTHORS   Sampath,P., Mazumder,B., Seshadri,V., Gerber,C.A., Chavatte,L.,
            Kinter,M., Ting,S.M., Dignam,J.D., Kim,S., Driscoll,D.M. and
            Fox,P.L.
  TITLE     Noncanonical function of glutamyl-prolyl-tRNA synthetase:
            gene-specific silencing of translation
  JOURNAL   Cell 119 (2), 195-208 (2004)
   PUBMED   15479637
REFERENCE   9  (bases 1 to 4461)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   10 (bases 1 to 4461)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY383705.1.
            
            On May 30, 2005 this sequence version replaced XM_213969.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY383705.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN13663622,
                                           SAMN13663629 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..4461
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="glutamyl-prolyl-tRNA synthetase 1"
                     /db_xref="GeneID:289352"
                     /db_xref="RGD:1310952"
     CDS             1..4461
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bifunctional aminoacyl-tRNA synthetase; bifunctional
                     glutamate/proline--tRNA ligase; proline--tRNA ligase-like"
                     /codon_start=1
                     /product="bifunctional glutamate/proline--tRNA ligase
                     isoform 1"
                     /protein_id="NP_001019409.1"
                     /db_xref="GeneID:289352"
                     /db_xref="RGD:1310952"
                     /translation="MAALCLTVNAGNPPLGCRVKVNKRNKSFMLSFLEALLAVEHVKG
                     DVSISVEEGKENLLRVSESVVFTDTNSILRYLARVAATSGLYGSNLMEHTEIDHWLEF
                     SATKLSSCDVLTSAIKELNHCLSLRTYLVGNSLTLADLCVWATLKGNAACQEHLRQSK
                     TLVHVNRWYGFLEAQQAFRSVGTKWDASANKATGAPDRKQDIGKFVELPGAEMGKVTV
                     RFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAM
                     LHIKPDQFTYTSDHFETIMKYAEKLIEEGKAYVDDTPADEMKAEPVEKNLQMWEEMKR
                     GSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDS
                     IEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNE
                     GLGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNILDAQEEMKEVARHP
                     KNPDVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNINITKIHKNPDGKITSLDA
                     KLNLENKDYKKTTKITWLAETTQALPVPAVCVTYEHLITKPVLGKDEDFKQYVNKDSK
                     HEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCILIYIPDGHTK
                     EMPTSGSKEKTKVEISKKETGSAPKERPAAAVSAPCAAAEDAAILYSRVAVQGDAVRD
                     LKAKKAPKEDIDAAVKQLLTLKAEYKEKTGQEYRPGNPPTAAVQTVSTKSPSNTGEYT
                     SLYNKVAAQGELVRKLKAEKAPKAKINDAVECLLSLKAEYKEKTGKEYVPGQLPASQN
                     SHSSPVSNAKPVGSETPEAKLLFDRVACQGEVVRKLKAEKASKDQVDSAVQELLQLKA
                     QYKSLTGIEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQGKDSSKSQGSGLS
                     SGGAGEGQGPKKQTRLGLEAKKEENLAEWYSQVITKSEMIEYYDVSGCYILRPWSYSI
                     WESIKDFFDAEIKKLGVENCYFPIFVSQGALEKEKNHIADFAPEVAWVTRSGKTELAE
                     PIAIRPTSETVMYPAYAKWVQSHRDLPIRLNQWCNVVRWEFKHPQPFLRTREFLWQEG
                     HSAFATFEEAADEVLQILELYARVYEELLAIPVVRGRKTEKEKFAGGDYTTTLEAFIS
                     ASGRAIQGATSHHLGQNFSKMCEIVFEDPKTPGEKQFAYQCSWGLTTRTIGVMIMVHG
                     DNMGLVLPPRVASVQVVVIPCGITNTLSEEDREALMAKCNEYRRRLLGADIRARVDLR
                     DNYSPGWKFNHWELKGVPVRLEVGPRDMKSCQFVAVRRDTGEKLTIAEKEAESKLKGV
                     LEDIQLNLFTRASEDLKSHMVVSDTLEDFQKVLDSGKVAQIPFCGEIDCEDWIKKTTA
                     RDQDVEPGAPSMGAKSLCIPFNPLCELQPGAMCVCGKNPAKFYTLFGRSY"
     misc_feature    88..2055
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="glutamate-tRNA ligase; Region: PLN02907"
                     /db_xref="CDD:215492"
     misc_feature    88..2055
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="glutamate-tRNA ligase; Region: PLN02907"
                     /db_xref="CDD:215492"
     misc_feature    2179..2328
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; Region: WEPRS_RNA;
                     cd00936"
                     /db_xref="CDD:238473"
     misc_feature    2179..2328
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; Region: WEPRS_RNA;
                     cd00936"
                     /db_xref="CDD:238473"
     misc_feature    order(2200..2202,2206..2208,2215..2217,2230..2232,
                     2245..2247,2257..2259,2281..2283,2305..2307)
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    order(2200..2202,2206..2208,2215..2217,2230..2232,
                     2245..2247,2257..2259,2281..2283,2305..2307)
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    2398..2547
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; Region: WEPRS_RNA;
                     cd00936"
                     /db_xref="CDD:238473"
     misc_feature    2398..2547
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; Region: WEPRS_RNA;
                     cd00936"
                     /db_xref="CDD:238473"
     misc_feature    order(2419..2421,2425..2427,2434..2436,2449..2451,
                     2464..2466,2476..2478,2500..2502,2524..2526)
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    order(2419..2421,2425..2427,2434..2436,2449..2451,
                     2464..2466,2476..2478,2500..2502,2524..2526)
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="tRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:238473"
     misc_feature    2632..2790
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WHEP-TRS domain; Region: WHEP-TRS; pfam00458"
                     /db_xref="CDD:459819"
     misc_feature    2632..2790
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="WHEP-TRS domain; Region: WHEP-TRS; pfam00458"
                     /db_xref="CDD:459819"
     misc_feature    2974..4458
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="prolyl-tRNA synthetase, family I; Region:
                     proS_fam_I; TIGR00408"
                     /db_xref="CDD:273062"
     misc_feature    2974..4458
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /note="prolyl-tRNA synthetase, family I; Region:
                     proS_fam_I; TIGR00408"
                     /db_xref="CDD:273062"
     exon            1..46
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            47..69
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            70..185
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            186..285
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            286..442
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            443..582
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            583..677
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            678..804
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            805..961
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1133
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1356
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1416
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1527
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1664
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1872
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1985
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2103
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2463
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2697
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2960
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3012
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3222
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3295
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3375
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3477
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3633
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3831
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4005
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4166
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4245
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4310
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4461
                     /gene="Eprs1"
                     /gene_synonym="Eprs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcgc tgtgccttac ggtgaacgcc ggaaaccctc cactgggttg tcgagttaaa
       61 gtgaacaaga gaaataaatc cttcatgttg tcatttttag aagctctgct ggcagtggag
      121 catgtgaaag gtgatgtcag catttctgtg gaagaaggga aggagaatct tcttcgggtt
      181 tctgagagtg tggtgttcac tgacacaaat tcaatcctgc gctacttggc tagagttgca
      241 gctacatctg ggctgtacgg ttctaacctg atggagcaca cggagattga tcattggttg
      301 gagttcagcg ctacaaagtt gtcttcgtgt gatgtgctga cttcggcaat caaggagctt
      361 aaccattgcc tgtctctgag aacatacctg gttgggaact ctttgacttt agcagattta
      421 tgtgtttggg ccaccctaaa aggaaatgct gcatgtcagg agcacttgag acagagcaaa
      481 accctagtcc acgttaaccg ctggtatggc tttcttgaag cccagcaggc cttccgttca
      541 gttggtacca agtgggatgc ttcagcaaac aaagctacag gggcacctga cagaaaacaa
      601 gatattggga aattcgtcga gcttccgggt gcagagatgg gaaaggtgac agtcagattc
      661 cccccagagg ctagtggtta cttacacatt gggcatgcaa aggctgctct tctgaaccag
      721 cactaccagg ttaactttaa aggcaaactg atcatgagat ttgatgacac aaacccagaa
      781 aaggaaaagg aagattttga gaaggtcatc ttggaagatg ttgcaatgct gcacattaaa
      841 ccagatcagt ttacttacac ttcagatcat tttgaaacta taatgaagta tgcagagaaa
      901 ttaattgaag aagggaaggc ctatgtggac gacactcccg cagacgagat gaaggcggag
      961 cctgttgaga agaatctaca aatgtgggaa gaaatgaaaa gaggaagcca gtttggtcag
     1021 tcctgttgcc tgcgagcaaa aattgacatg agtagtaaca atgggtgtat gagggaccca
     1081 accctttacc gctgcaaaat ccagccccac ccaagaactg ggaataaata caatgtttac
     1141 ccaacgtatg actttgcctg tcctatagtg gacagcattg aaggtgttac tcatgccttg
     1201 aggacgacag agtaccacga ccgagatgag cagttttact ggattattga agccttaggc
     1261 ataaggaaac catacatctg ggaatacagt cgcttaaatc tcaacaacac agtgctgtcc
     1321 aagagaaagc ttacgtggtt tgtcaatgaa ggactgggct cctcaaggtc tgttgtaaac
     1381 atggaatggg acaaaatctg ggcgtttaac aaaaaggtta ttgaccctgt ggctccaagg
     1441 tacgttgcat tgctgaagaa ggaggtgatc ccagtgaaca tcctggacgc gcaggaggag
     1501 atgaaggaag tagccagaca tcccaagaat cctgatgttg gtttgaagcc tgtgtggtat
     1561 agtcccaagg ttttcataga aggagctgat gcagagactt tctcagaggg tgaaatggtc
     1621 acatttataa actggggcaa catcaacatt actaaaatac acaaaaatcc agatggaaaa
     1681 attacatctc tggatgcaaa attgaatttg gaaaacaaag actacaagaa aacaactaag
     1741 atcacttggc ttgcggagac cacacaggct ctccctgtcc cggcagtctg tgtcacttat
     1801 gagcacttga ttacaaagcc agtgctagga aaagacgagg acttcaagca gtacgtcaac
     1861 aaagacagta agcatgaaga actaatgcta ggagatccct gccttaagga tttgaagaaa
     1921 ggagacatca tacaattgca gaggcgcgga ttcttcatat gcgaccagcc gtacgaacct
     1981 gtcagcccat atagttgcaa agaagccccc tgcatcttga tatatatacc cgatgggcac
     2041 accaaggaga tgccaacatc tggatcaaag gaaaagacta aagtggaaat ctcaaaaaag
     2101 gagaccggct ctgctcctaa ggagagaccc gcagctgctg tgagtgctcc ctgtgctgca
     2161 gctgaggacg ctgccatcct ctacagcaga gtggcggtcc agggtgatgc ggttcgcgac
     2221 ctgaaagcga agaaagcacc aaaggaggat attgacgcag ctgtgaaaca gcttttgact
     2281 ttgaaggctg agtataaaga gaaaactggg caggagtata gacctgggaa cccccctact
     2341 gcagcagtgc agactgtttc tacaaagtcc ccatccaaca ccggggaata cacatcttta
     2401 tacaataaag ttgctgccca aggggagctg gtccggaagc tgaaagctga aaaggctcct
     2461 aaggctaaaa taaatgatgc tgtagaatgc ttactgtccc tgaaagctga gtataaagaa
     2521 aaaactggga aggagtatgt acctggccaa ctcccagcat ctcagaactc acattcaagt
     2581 cctgtcagca atgccaagcc tgttggatca gagacaccgg aagccaaact gctgtttgac
     2641 agagtggctt gtcaaggaga agtagttcgg aaacttaaag ctgagaaggc ctctaaggat
     2701 caagtggatt cagccgtaca agaacttctt cagctgaagg cacagtacaa gtcactgaca
     2761 ggaattgagt ataagcctgt gtctgctact ggggcagaag acaaagataa gaagaagaaa
     2821 gaaaaagaaa ataagtctga aaagcagaat aagcctcaga aacaaaatga tggccaaggg
     2881 aaagactctt ctaaaagcca aggcagcggg ctgtcgtccg gtggagcagg agaagggcaa
     2941 gggcccaaga aacagaccag attgggtctt gaagcaaaaa aagaagaaaa tcttgccgaa
     3001 tggtattccc aagtcatcac gaagtcagag atgatcgaat actacgatgt gagtggctgc
     3061 tatattctcc gaccctggtc gtactccatc tgggaatcca ttaaggactt ctttgacgcg
     3121 gagatcaaga agctcggcgt tgagaactgc tacttcccca tattcgtgtc ccagggcgca
     3181 ctagagaagg agaagaacca cattgctgac tttgctcccg aggttgcttg ggtgacaaga
     3241 tctggaaaga cagagctggc agagccgatt gccatccgtc ctactagtga aacagtaatg
     3301 tatcctgcat atgcaaaatg ggtgcagtcc cacagagacc tgcccatcag gctcaaccag
     3361 tggtgcaacg tggtgcgctg ggagttcaaa cacccacaac ctttcctccg cactcgggag
     3421 ttcctatggc aggaggggca cagcgccttt gccacctttg aggaggcagc tgacgaggtg
     3481 ttacagatcc tcgagttata tgctcgagtg tatgaggagc tcttggcaat ccccgtcgtg
     3541 agaggaagga agactgagaa ggaaaagttt gcaggaggag actatacaac cacactagaa
     3601 gccttcatat ctgccagcgg acgcgctatc cagggagcaa catcacacca tttaggccag
     3661 aatttctcca aaatgtgtga aatagttttt gaagatccca agacaccagg agaaaagcag
     3721 tttgcatacc agtgctcctg gggcctgaca actcgcacta tcggtgtgat gatcatggtc
     3781 catggggaca acatgggctt agtgttacct ccccgtgtag cgtctgtcca ggtggtagtc
     3841 attccctgtg gaatcacgaa taccttgtct gaagaagaca gagaggccct gatggcaaaa
     3901 tgcaatgagt acaggagacg gctgctcggc gctgacatcc gagctcgagt cgatctacga
     3961 gacaactact caccaggctg gaagttcaac cactgggagc tcaagggtgt tccagtcaga
     4021 cttgaggtgg ggccacgtga tatgaagagc tgtcagtttg tagcagtcag acgagatact
     4081 ggagagaagc tgacaattgc tgaaaaggag gcggagtcta aactgaaagg ggttttggaa
     4141 gacatccagc ttaacctttt cacaagggct tctgaagacc ttaaatctca catggttgta
     4201 tcggatacac tggaagactt tcagaaggtg ctagattctg ggaaggttgc acagattcca
     4261 ttctgtgggg aaattgactg tgaggactgg atcaaaaaga caacggccag ggatcaggat
     4321 gtggaacctg gtgctccatc catgggagcc aaaagccttt gcattccttt caaccctctg
     4381 tgtgagctgc agccaggagc catgtgtgtc tgtggcaaga atcctgccaa gttctacacc
     4441 ttgtttggtc ggagttactg a
//
LOCUS       NM_001008853             999 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, locus M6, gene 2 (RT1-M6-2), mRNA.
ACCESSION   NM_001008853 XM_345076
VERSION     NM_001008853.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Lambracht-Washington,D., Moore,Y.F., Wonigeit,K. and Lindahl,K.F.
  TITLE     Structure and expression of MHC class Ib genes of the central M
            region in rat and mouse: M4, M5, and M6
  JOURNAL   Immunogenetics 60 (3-4), 131-145 (2008)
   PUBMED   18324395
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883052.1.
            
            On Jan 5, 2005 this sequence version replaced XM_345076.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN09345238, SAMN09345329
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..999
                     /gene="RT1-M6-2"
                     /note="RT1 class I, locus M6, gene 2"
                     /db_xref="GeneID:365527"
                     /db_xref="RGD:1595815"
     CDS             1..999
                     /gene="RT1-M6-2"
                     /note="MHC class Ib antigen"
                     /codon_start=1
                     /product="RT1 class I, locus M6, gene 2 precursor"
                     /protein_id="NP_001008853.1"
                     /db_xref="GeneID:365527"
                     /db_xref="RGD:1595815"
                     /translation="MGAPVLHATLLLLSAFLALTQTKNQSFAGSHSRQYLVTATTSRP
                     GLRDPHVFIVGYVDHMPFMRFDSDGVAQRIQARGPWVKQMGPEYLEMERKNAERYSHR
                     ARENLRFAIQVYNQSDKGHHRHAFDGQHYISLNSDLTTWSVADSTAQITKRRWEADGV
                     AEAFSHFLKVSCVEWLQKHLETGKETLQRSDPPKTHVTHHPRPEGDATLRCWALDFYP
                     ADITLTWQEEEEEEELTQDMELVETRPAGDGTFQKWASVVVPSGEEQKYTCHVYHEGL
                     PEPLTLRWKPATWPVVGITVGVVLLGFVTIGALIAIVTMRKKRADPVDPVDLMDPV"
     sig_peptide     1..66
                     /gene="RT1-M6-2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    85..561
                     /gene="RT1-M6-2"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    85..561
                     /gene="RT1-M6-2"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    571..852
                     /gene="RT1-M6-2"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    571..852
                     /gene="RT1-M6-2"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    574..597
                     /gene="RT1-M6-2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    574..597
                     /gene="RT1-M6-2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    619..648
                     /gene="RT1-M6-2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    619..648
                     /gene="RT1-M6-2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    order(628..630,634..636,721..726,730..738,754..756,
                     760..762)
                     /gene="RT1-M6-2"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(628..630,634..636,721..726,730..738,754..756,
                     760..762)
                     /gene="RT1-M6-2"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(649..657,745..747,820..822)
                     /gene="RT1-M6-2"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    order(649..657,745..747,820..822)
                     /gene="RT1-M6-2"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    661..678
                     /gene="RT1-M6-2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    661..678
                     /gene="RT1-M6-2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    685..702
                     /gene="RT1-M6-2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    685..702
                     /gene="RT1-M6-2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    712..738
                     /gene="RT1-M6-2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    712..738
                     /gene="RT1-M6-2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    745..777
                     /gene="RT1-M6-2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    745..777
                     /gene="RT1-M6-2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    796..819
                     /gene="RT1-M6-2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    796..819
                     /gene="RT1-M6-2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    838..849
                     /gene="RT1-M6-2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    838..849
                     /gene="RT1-M6-2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    862..957
                     /gene="RT1-M6-2"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; Region:
                     TM_EGFR-like; cd12087"
                     /db_xref="CDD:213052"
     misc_feature    862..957
                     /gene="RT1-M6-2"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; Region:
                     TM_EGFR-like; cd12087"
                     /db_xref="CDD:213052"
     misc_feature    order(865..867,874..879,886..891,895..900,904..909,
                     916..918)
                     /gene="RT1-M6-2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:213052"
     misc_feature    order(865..867,874..879,886..891,895..900,904..909,
                     916..918)
                     /gene="RT1-M6-2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:213052"
     exon            1..85
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..358
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..571
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..853
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..961
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..999
                     /gene="RT1-M6-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggctc cagtgctgca tgccaccctc ctgctgctct cagccttcct ggctctgacc
       61 caaaccaaga accagagttt tgctggttca cactccaggc agtatttggt aaccgcgacc
      121 acgtctcgac cgggtcttag agatccccat gtcttcattg ttggctatgt ggaccacatg
      181 ccatttatgc gctttgacag tgatggagtt gctcagagga tccaggcaag aggaccttgg
      241 gtgaagcaga tggggcctga gtatttggaa atggagagaa agaatgcgga gaggtattca
      301 cacagggctc gagaaaacct gcgattcgca atccaggtct ataaccagag cgataaaggg
      361 catcatagac atgcttttga cggccaacat tacatcagcc tgaactcgga cctgacaaca
      421 tggagtgtcg cagacagcac agctcagatc accaagcgac ggtgggaggc agatggtgta
      481 gcagaggcct tcagtcactt cttgaaagtc tcttgtgttg aatggctgca gaagcacttg
      541 gagacaggga aggagactct acagcgctca gatcccccaa agacacatgt gacccatcac
      601 cccagacctg aaggtgatgc caccctgagg tgttgggccc tggacttcta ccctgctgac
      661 atcaccctga cctggcagga ggaggaggag gaggaggaac tgacacagga catggagctt
      721 gtggagacca ggcctgcagg ggatggaacc ttccagaagt gggcatctgt ggtggtgcct
      781 tctggggagg agcagaaata cacttgtcat gtgtaccatg aggggctgcc tgagcccctc
      841 acactgagat ggaaaccagc aacttggcct gtggttggaa taactgttgg tgtagttctc
      901 cttgggtttg tcaccattgg agctctgatt gccattgtga ccatgaggaa gaagagagca
      961 gaccctgtgg atcctgtgga ccttatggat ccagtgtga
//
LOCUS       NM_022943               3024 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MER proto-oncogene, tyrosine kinase (Mertk),
            mRNA.
ACCESSION   NM_022943
VERSION     NM_022943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Su,X., Chen,W., Fu,Y., Wu,B., Mao,F., Zhao,Y., Yang,Q. and Lan,D.
  TITLE     Protective Role of MerTK in Diabetic Peripheral Neuropathy via
            Inhibition of the NF-kappaB Signaling Pathway
  JOURNAL   Exp Clin Endocrinol Diabetes 132 (7), 396-406 (2024)
   PUBMED   38588709
  REMARK    GeneRIF: Protective Role of MerTK in Diabetic Peripheral Neuropathy
            via Inhibition of the NF-kappaB Signaling Pathway.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Edvinsson,J.C.A., Ran,C., Olofsgard,F.J., Steinberg,A.,
            Edvinsson,L. and Belin,A.C.
  TITLE     MERTK in the rat trigeminal system: a potential novel target for
            cluster headache?
  JOURNAL   J Headache Pain 25 (1), 85 (2024)
   PUBMED   38783191
  REMARK    GeneRIF: MERTK in the rat trigeminal system: a potential novel
            target for cluster headache?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Pele,T., Giraud,S., Joffrion,S., Ameteau,V., Delwail,A.,
            Goujon,J.M., Macchi,L., Hauet,T., Dkhissi,F. and Benzakour,O.
  TITLE     Study of the Role of the Tyrosine Kinase Receptor MerTK in the
            Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
  JOURNAL   Int J Mol Sci 22 (22), 12103 (2021)
   PUBMED   34829984
  REMARK    GeneRIF: Study of the Role of the Tyrosine Kinase Receptor MerTK in
            the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Mao,Y. and Finnemann,S.C.
  TITLE     Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore
            Phagocytic Capacity to Retinal Pigment Epithelium Lacking the
            Engulfment Receptor MerTK
  JOURNAL   Cells 10 (8), 1927 (2021)
   PUBMED   34440696
  REMARK    GeneRIF: Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore
            Phagocytic Capacity to Retinal Pigment Epithelium Lacking the
            Engulfment Receptor MerTK.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Lorach,H., Kang,S., Dalal,R., Bhuckory,M.B., Quan,Y. and
            Palanker,D.
  TITLE     Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis
            Pigmentosa Associated with MERTK Mutation
  JOURNAL   Sci Rep 8 (1), 11312 (2018)
   PUBMED   30054542
  REMARK    GeneRIF: The long-term preservation of photoreceptors we observed
            indicates that MERTK-related form of inherited retinal
            degeneration, which has currently no cure, could be amenable to
            laser therapy or subretinal surgery, to extend the visual function,
            potentially for life.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Vollrath,D., Feng,W., Duncan,J.L., Yasumura,D., D'Cruz,P.M.,
            Chappelow,A., Matthes,M.T., Kay,M.A. and LaVail,M.M.
  TITLE     Correction of the retinal dystrophy phenotype of the RCS rat by
            viral gene transfer of Mertk
  JOURNAL   Proc Natl Acad Sci U S A 98 (22), 12584-12589 (2001)
   PUBMED   11592982
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Lu,Q. and Lemke,G.
  TITLE     Homeostatic regulation of the immune system by receptor tyrosine
            kinases of the Tyro 3 family
  JOURNAL   Science 293 (5528), 306-311 (2001)
   PUBMED   11452127
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   D'Cruz,P.M., Yasumura,D., Weir,J., Matthes,M.T., Abderrahim,H.,
            LaVail,M.M. and Vollrath,D.
  TITLE     Mutation of the receptor tyrosine kinase gene Mertk in the retinal
            dystrophic RCS rat
  JOURNAL   Hum Mol Genet 9 (4), 645-651 (2000)
   PUBMED   10699188
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Lu,Q., Gore,M., Zhang,Q., Camenisch,T., Boast,S., Casagranda,F.,
            Lai,C., Skinner,M.K., Klein,R., Matsushima,G.K., Earp,H.S.,
            Goff,S.P. and Lemke,G.
  TITLE     Tyro-3 family receptors are essential regulators of mammalian
            spermatogenesis
  JOURNAL   Nature 398 (6729), 723-728 (1999)
   PUBMED   10227296
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Fernando,C.C. and Fraser,H.H.
  TITLE     Technical report: fallopian tube recanalization facilitated by a
            hydrophillic glide wire
  JOURNAL   Australas Radiol 36 (4), 323 (1992)
   PUBMED   1299193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF208235.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="RCS-rdy+"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="MER proto-oncogene, tyrosine kinase"
                     /db_xref="GeneID:65037"
                     /db_xref="RGD:69283"
     exon            1..97
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /EC_number="2.7.10.1"
                     /note="proto-oncogene tyrosine-protein kinase MER;
                     tyrosine-protein kinase Mer; retinal dystrophy; receptor
                     tyrosine kinase MerTK; proto-oncogene c-Mer; Receptor
                     tyrosine tinase gene probably the gene for Rdy; c-mer
                     proto-oncogene tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Mer precursor"
                     /protein_id="NP_075232.1"
                     /db_xref="GeneID:65037"
                     /db_xref="RGD:69283"
                     /translation="MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPA
                     DHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEH
                     KSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSV
                     QRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGP
                     PEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIK
                     VIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSA
                     SPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNES
                     SNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNA
                     TCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFV
                     LMGLILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSE
                     ELQNKLEDVVVDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLR
                     EIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSR
                     IESVPKSIPLQTLLKFMVDIAQGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLS
                     KKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG
                     VQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCWSADPLDRPTFSVLRLQLEKLSESL
                     PDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDSIIASCTAGAAVSVVMAEV
                     HENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKNGISWSHHSTLPL
                     GSPSPDELLFADDSSGDSEVLM"
     sig_peptide     40..93
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1)"
     mat_peptide     94..3021
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /product="Tyrosine-protein kinase Mer. /id=PRO_0000024445"
                     /note="propagated from UniProtKB/Swiss-Prot (P57097.1)"
     misc_feature    109..270
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="propagated from UniProtKB/Swiss-Prot (P57097.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    325..606
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    325..606
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    352..366
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    352..366
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    361..363
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    403..417
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    403..417
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    496..510
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    496..510
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    532..534
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    538..555
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    538..555
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    580..591
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    580..591
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    616..861
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Second immunoglobulin (Ig)-like domain of Axl/Tyro3
                     family receptor tyrosine kinases (RTKs); member of the
                     I-set of Ig superfamily (IgSF) domains; Region:
                     IgI_2_Axl_Tyro3_like; cd05749"
                     /db_xref="CDD:409407"
     misc_feature    616..861
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Second immunoglobulin (Ig)-like domain of Axl/Tyro3
                     family receptor tyrosine kinases (RTKs); member of the
                     I-set of Ig superfamily (IgSF) domains; Region:
                     IgI_2_Axl_Tyro3_like; cd05749"
                     /db_xref="CDD:409407"
     misc_feature    616..627
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409407"
     misc_feature    616..627
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409407"
     misc_feature    634..648
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409407"
     misc_feature    634..648
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409407"
     misc_feature    643..645
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    658..687
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409407"
     misc_feature    658..687
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409407"
     misc_feature    667..669
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    700..723
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409407"
     misc_feature    700..723
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409407"
     misc_feature    724..726
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    727..738
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409407"
     misc_feature    727..738
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409407"
     misc_feature    751..786
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409407"
     misc_feature    751..786
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409407"
     misc_feature    793..822
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409407"
     misc_feature    793..822
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409407"
     misc_feature    817..834
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:409407"
     misc_feature    817..834
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:409407"
     misc_feature    order(826..834,838..840)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:409407"
     misc_feature    order(826..834,838..840)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:409407"
     misc_feature    832..861
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409407"
     misc_feature    832..861
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409407"
     misc_feature    874..1158
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    874..1158
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(874..876,1075..1077,1120..1122)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(874..876,1075..1077,1120..1122)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    904..906
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    970..972
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1009..1011
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1030..1032
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1084..1086
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    order(1123..1128,1132..1137)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1123..1128,1132..1137)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1180..1458
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1180..1458
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1189..1191
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1207..1209
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1348..1350
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    1384..1386
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); glycosylation site"
     misc_feature    order(1429..1434,1438..1443)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1429..1434,1438..1443)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1531..1593
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="propagated from UniProtKB/Swiss-Prot (P57097.1);
                     transmembrane region"
     misc_feature    1651..1653
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12866; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); phosphorylation site"
     misc_feature    1759..2610
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Catalytic Domain of the Protein Tyrosine Kinase,
                     Mer; Region: PTKc_Mer; cd14204"
                     /db_xref="CDD:271106"
     misc_feature    1759..2610
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Catalytic Domain of the Protein Tyrosine Kinase,
                     Mer; Region: PTKc_Mer; cd14204"
                     /db_xref="CDD:271106"
     misc_feature    order(1801..1815,1825..1827,1873..1875,1879..1881,
                     1972..1974,2038..2046,2056..2058,2191..2193,2203..2208,
                     2212..2214,2245..2247,2299..2313,2338..2340,2440..2442)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="active site"
                     /db_xref="CDD:271106"
     misc_feature    order(1801..1815,1825..1827,1873..1875,1879..1881,
                     1972..1974,2038..2046,2056..2058,2191..2193,2203..2208,
                     2212..2214,2245..2247,2299..2313,2338..2340,2440..2442)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="active site"
                     /db_xref="CDD:271106"
     misc_feature    order(1801..1806,1825..1827,1873..1875,1972..1974,
                     2038..2046,2056..2058,2191..2193,2203..2208,2212..2214,
                     2245..2247)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271106"
     misc_feature    order(1801..1806,1825..1827,1873..1875,1972..1974,
                     2038..2046,2056..2058,2191..2193,2203..2208,2212..2214,
                     2245..2247)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271106"
     misc_feature    order(2191..2193,2203..2205,2299..2313,2338..2340,
                     2440..2442)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271106"
     misc_feature    order(2191..2193,2203..2205,2299..2313,2338..2340,
                     2440..2442)
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271106"
     misc_feature    2242..2319
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271106"
     misc_feature    2242..2319
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271106"
     misc_feature    2269..2271
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q12866; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); phosphorylation site"
     misc_feature    2281..2283
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q12866; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); phosphorylation site"
     misc_feature    2284..2286
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q12866; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); phosphorylation site"
     misc_feature    2638..2640
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q60805; propagated from
                     UniProtKB/Swiss-Prot (P57097.1); phosphorylation site"
     exon            98..506
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            507..607
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            608..781
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            782..868
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            869..984
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1168
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1320
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1474
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1628
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1714
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1810
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1891
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1984
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2103
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2213
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2373
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2510
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3024
                     /gene="Mertk"
                     /gene_synonym="rdy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catctgtccg gagagaactg ccagatccgc ggccccgcga tggttctggc cccactactg
       61 ctggggctgc tgctgctatc cgcactctgg aatggaggca ctgctgaaaa ggaggaagaa
      121 atcaagccag atcagccatt ttcagggcct ttaccaggga gcctaccagc tgaccacagg
      181 ccattcttcg cccctcactc cagtggggac cagctgtcac catcccagac tggaagatca
      241 catccagcac acacagccac tccccagatg acctctgcag catcaaacct cctgcctcct
      301 gttgcattta aaaacacaat tggacgcata gtactttcgg aacataaaag tgtcaaattt
      361 aattgctcga tcaacattcc taacgtgtat caagaaacag ctggcatttc gtggtggaaa
      421 gatggaaagg aactgcttgg ggcacatcat tcaatcacac agttttatcc tgatgaggaa
      481 ggggtatcaa taattgcatt gttcagcata accagtgtgc agcgctcaga caatgggtcg
      541 tacatctgta agatgaaggt gaacgataga gaggttgtgt ctgatcccat atacgtggaa
      601 gtccaaggac tcccttactt tactaagcag cctgagagcg tgaatgtcac cagaaacaca
      661 gccttcaacc tcacctgcca ggctgtggga ccccctgagc ccgtcaacat cttctgggtt
      721 caaaatagca gccgtgttaa tgaaaatcca gaaaggtccc cgtctgtcct aactgtcgct
      781 ggtctgacag agaccgcagt cttcagctgt gaggcccaca acgacaaagg actgacggtg
      841 tccaagggtg tacagatcaa catcaaagtc atcccttccc cacccactga agtccatatc
      901 ctcaacagca cagcgcacag catcctggtc tcctgggtcc cagggtttga tggctactcc
      961 ccacttcaga actgcagcat tcaggtcaag gaagctgacc agctgagtaa tggctcagtc
     1021 atggttttta atacctctgc ttcgccacat ctgtatgaag tccagcagct gcaagccctg
     1081 gctaattaca gcgtcactgt gtcctgtcgg aatgagattg gctggtctgc agtgagccct
     1141 tggatcctgg ccagcactac agaaggagct ccagcagtgg cgcctctaaa catcactgtg
     1201 tttctgaacg aatccagcaa caacctggaa atcagatgga cgaagcctcc aattaagcgg
     1261 caggatgggg aactggtggg ctaccggata tctcacgtgt gggagagtgc ggggacttcc
     1321 aaagagcttt ctgaagaagt cagccagaat ggcagctggg ctcaggttcc tgtccaaatg
     1381 cacaatgcca cctgcacagt gagaatcgcc gtcatcacta aagggggcat tgggcccttc
     1441 agtgagccag tggacgtagc cattccggag cacagtaggg tagattacgc accctcatca
     1501 accccagccc ctggcaacac cgagtctatg ctcatcatcc tgggctgctt ctgcgggttt
     1561 gttctcatgg ggttgattct gtatctttct ctggccatca aaaggagagt ccaggaaaca
     1621 aagtttgggg gtgcattctc cgaggaggac tcccaattag ttgtaaatta cagagcaaag
     1681 aagtccttct gtcggcgagc catcgagctt accttgcaaa gcctgggggt gagcgaggag
     1741 ctgcaaaaca agctagaaga tgttgtggtt gacagaaatc ttctaattct tgggaaagtt
     1801 ctgggcgaag gagagtttgg gtctgtaatg gaaggaaatc tgaagcagga agatgggact
     1861 tctcagaagg tggcagtgaa gaccatgaag ttggacaact tttctctacg ggagatcgag
     1921 gagtttctca gcgaagcagc gtgcatgaaa gacttcaatc acccaaacgt catccggctt
     1981 ctaggcgtgt gtatagaact gagctctcaa ggcatcccga agcccatggt gattttaccc
     2041 ttcatgaaat acggagacct ccacaccttc ctgctatatt cccggataga atcagtaccg
     2101 aagtccatcc ccctgcagac actgctgaag ttcatggtgg acattgccca gggaatggag
     2161 tacctgagca gcaggaattt tctccacagg gatttagctg ctcggaattg catgttgcgg
     2221 gatgacatga ctgtctgcgt ggcagacttt ggcctctcta agaagattta cagtggtgat
     2281 tattaccgcc aaggccgcat tgccaaaatg cctgtgaagt ggatcgccat agagagcctg
     2341 gcggaccgag tctacacaag caagagtgac gtgtgggctt ttggcgtgac catgtgggaa
     2401 atagcaacac ggggaatgac tccctatcct ggagtccaga accatgagat gtacgattac
     2461 cttctccacg gccacaggct gaagcagccc gaggactgcc tggatgatct gtatgaaatc
     2521 atgtactctt gctggagtgc tgatcccctg gaccgaccca ccttctcagt gctgaggctg
     2581 cagctggaaa agctctccga gagtttgcct gatgcccagg acaaagaatc catcatctac
     2641 atcaatacac agttactaga gagctgcgag ggcctagcca acaggtcctc cctcgcaggg
     2701 ctagacatga acattgatcc tgactccatc attgcctctt gcacagcagg tgctgctgtc
     2761 agcgtggtca tggcggaagt tcacgagaac aaccttcatg aggaaagata catcttaaat
     2821 gggggcaacg aggaatggga agatgtggcc tccactccat ttgctacagt cacagctgga
     2881 aaagatggtg tgttaccaga ggacagactc accaaaaatg gcatctcctg gtctcaccat
     2941 agtacgctac ccttggggag cccatcacca gatgaacttc tgtttgcaga cgactcctcg
     3001 ggagactctg aagttctgat gtga
//
LOCUS       NM_023993               1008 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 119 (Tas2r119),
            mRNA.
ACCESSION   NM_023993
VERSION     NM_023993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Dehkordi,O., Rose,J.E., Fatemi,M., Allard,J.S., Balan,K.V.,
            Young,J.K., Fatima,S., Millis,R.M. and Jayam-Trouth,A.
  TITLE     Neuronal expression of bitter taste receptors and downstream
            signaling molecules in the rat brainstem
  JOURNAL   Brain Res 1475, 1-10 (2012)
   PUBMED   22836012
  REMARK    GeneRIF: T2R1, a receptor for bitter taste, is expressed in
            brainstem.
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   5  (bases 1 to 1008)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   6  (bases 1 to 1008)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1008)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   8  (bases 1 to 1008)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227140.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227140.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1008
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="taste receptor, type 2, member 119"
                     /db_xref="GeneID:78979"
                     /db_xref="RGD:620733"
     CDS             1..1008
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="T2R19; T2R119; taste receptor type 2 member 1;
                     taste receptor type 2 member 19"
                     /codon_start=1
                     /product="taste receptor type 2 member 119"
                     /protein_id="NP_076483.1"
                     /db_xref="GeneID:78979"
                     /db_xref="RGD:620733"
                     /translation="MMEGHILFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPL
                     DLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVFIINELSLWFATWLGVF
                     YCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLF
                     PKNATQVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMVGTREYSG
                     HAHISAMLSILSFLILYLSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLI
                     LGNPKLKRNAKMFIVHCKCCHCTRAWVTSRSPRLSDLPVPPTHPSANKTSCSEACIMP
                     S"
     misc_feature    19..861
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="mammalian taste receptor 2, subtype 1, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R1; cd15016"
                     /db_xref="CDD:320144"
     misc_feature    19..861
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="mammalian taste receptor 2, subtype 1, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R1; cd15016"
                     /db_xref="CDD:320144"
     misc_feature    22..99
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320144"
     misc_feature    22..99
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320144"
     misc_feature    22..84
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    130..192
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320144"
     misc_feature    133..207
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320144"
     misc_feature    235..303
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320144"
     misc_feature    235..303
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320144"
     misc_feature    241..243
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKU1.1); glycosylation site"
     misc_feature    244..306
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    373..435
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    382..432
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320144"
     misc_feature    382..432
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320144"
     misc_feature    487..489
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKU1.1); glycosylation site"
     misc_feature    511..582
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320144"
     misc_feature    511..582
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320144"
     misc_feature    529..591
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    652..729
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320144"
     misc_feature    652..729
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320144"
     misc_feature    673..735
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    760..837
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320144"
     misc_feature    760..837
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320144"
     misc_feature    769..831
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     transmembrane region"
     misc_feature    922..981
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..1008
                     /gene="Tas2r119"
                     /gene_synonym="T2R1; Tas2r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatggaag ggcatatact cttcttcttt ttggttgtga tggtgcagtt tgtcactggg
       61 gtcttggcaa atggcctcat tgtggttgtc catgctattg acttgatcat gtggaagaaa
      121 atggccccgt tggatctgct tctattttgc ctggcgactt ctcggatcat tctgcagtta
      181 tgtatattgt ttgcacaatt gtgtctattc tctttggtga gacacacttt atttgaggac
      241 aatattacct ttgtcttcat cataaatgaa ctgagtcttt ggtttgctac atggctcggt
      301 gttttctact gtgccaagat tgctaccatt cctcacccac tctttctgtg gctgaagatg
      361 aggatatcca ggttggtacc atggctgatc ctgggatctg tgctctatgt aattattact
      421 actttcatcc atagcagaga gacttcagca atccttaaac caatttttat aagccttttt
      481 cctaaaaatg caactcaagt cggaacaggg catgccacac tactctcagt cctggtcctt
      541 gggctcacac tgccgttgtt catctttact gttgctgttc tgctcttgat atactccctg
      601 tggaattata gcaggcagat gaggactatg gtaggcacca gggagtatag cggacatgct
      661 cacatcagtg caatgctgtc cattctatca ttcctcatcc tctatctctc ccactacatg
      721 gtggctgttc tgatctctac tcaagtcctc taccttggaa gcagaacctt tgtattctgc
      781 ttactggtta ttggtatgta cccctcaata cactcgattg tcttaatttt aggaaatcct
      841 aagctgaaac gaaatgcaaa aatgttcatt gtccattgta agtgttgtca ttgtacaaga
      901 gcttgggtca cctcaaggag cccaagactc agtgacttgc cagtgcctcc tactcatccc
      961 tcagccaaca agacatcctg ctcagaagcc tgtataatgc catcctaa
//
LOCUS       NM_001008852             993 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, locus M6, gene 1 (RT1-M6-1), mRNA.
ACCESSION   NM_001008852 XM_579246
VERSION     NM_001008852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 993)
  AUTHORS   Lambracht-Washington,D., Moore,Y.F., Wonigeit,K. and Lindahl,K.F.
  TITLE     Structure and expression of MHC class Ib genes of the central M
            region in rat and mouse: M4, M5, and M6
  JOURNAL   Immunogenetics 60 (3-4), 131-145 (2008)
   PUBMED   18324395
REFERENCE   2  (bases 1 to 993)
  AUTHORS   Lambracht-Washington,D. and Fischer Lindahl,K.
  TITLE     Active MHC class Ib genes in rat are pseudogenes in the mouse
  JOURNAL   Immunogenetics 56 (2), 118-121 (2004)
   PUBMED   15069589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883052.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579246.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..993
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="RT1 class I, locus M6, gene 1"
                     /db_xref="GeneID:414785"
                     /db_xref="RGD:1598232"
     CDS             1..993
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="MHC class Ib antigen"
                     /codon_start=1
                     /product="RT1 class I, locus M6, gene 1 precursor"
                     /protein_id="NP_001008852.1"
                     /db_xref="GeneID:414785"
                     /db_xref="RGD:1598232"
                     /translation="MGAPVLHATLLLLSAFLALTQTKNQSFAGSHFMQYLVTTTSSQP
                     GLQDSHVCIVGHVDYMPFMRFDSDGAAQRIQTRGPWMKQMGPEYLEMERKNAEGYSHR
                     ARENLRFAIQVYNQSDKAHYSHAFDGQHYISLNSDLTTWSVGDSTAQITKRRWEADGV
                     AEALSHFLKVSCVEHLQKHLETGKETLQRSDPPKAHVTLHPRPEGDVTLRCWALGFYP
                     ADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPNGEEQKYTCLVEHEGLPE
                     PLTLRWKPATWPVVGITVGVVLLGFVIIGALIAIVTMRKKRADPVDPVDLMDPV"
     sig_peptide     1..66
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    85..561
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    85..561
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    565..849
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    565..849
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    619..633
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409606"
     misc_feature    619..633
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409606"
     misc_feature    664..678
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409606"
     misc_feature    664..678
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409606"
     misc_feature    757..771
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409606"
     misc_feature    757..771
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409606"
     misc_feature    790..807
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409606"
     misc_feature    790..807
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409606"
     misc_feature    835..846
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409606"
     misc_feature    835..846
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409606"
     misc_feature    856..951
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; Region:
                     TM_EGFR-like; cd12087"
                     /db_xref="CDD:213052"
     misc_feature    856..951
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; Region:
                     TM_EGFR-like; cd12087"
                     /db_xref="CDD:213052"
     misc_feature    order(859..861,868..873,880..885,889..894,898..903,
                     910..912)
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:213052"
     misc_feature    order(859..861,868..873,880..885,889..894,898..903,
                     910..912)
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:213052"
     exon            1..85
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            86..358
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..571
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            572..847
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            848..955
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
     exon            956..993
                     /gene="RT1-M6-1"
                     /gene_synonym="RT1-M6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggctc cagtgctgca tgctacccta ctgctgctct cagccttcct ggctctgacc
       61 caaaccaaga accagagttt tgctggttca cacttcatgc agtatttggt aaccaccacc
      121 tcgtctcaac ccggtcttca agattcgcat gtctgcattg ttggccatgt ggactacatg
      181 ccatttatgc gctttgacag tgatggagct gctcagagga tccagacgag agggccttgg
      241 atgaagcaga tggggcctga gtatttggaa atggagagaa agaatgcgga ggggtattca
      301 cacagggctc gagaaaacct gcgattcgca atccaagtct ataaccagag cgataaagcg
      361 cactatagcc atgcttttga cggccaacat tacatcagcc tgaactcgga cctgacaaca
      421 tggagtgtgg gagacagcac agctcagatc accaagcgac ggtgggaggc agatggtgta
      481 gcagaggcct tgagtcactt cttgaaagtc tcttgtgttg aacacctgca gaagcacttg
      541 gagacaggga aggagactct acagcgctca gatcccccaa aggcacatgt gacccttcac
      601 cccagacctg aaggtgatgt caccctgagg tgctgggccc tgggcttcta ccctgctgac
      661 atcaccctga cctggcagtt gaatggggag gacctgaccc aggacatgga gcttgtggag
      721 accaggcctg caggggatgg aaccttccag aagtgggcat ctgtggtggt gcctaatggg
      781 gaggagcaga agtacacatg ccttgtggag catgaggggc tgcctgagcc cctcacactg
      841 agatggaaac cagcaacttg gcctgtggtt ggaataactg ttggtgtagt tctccttggg
      901 tttgtcatca ttggagctct gattgccatt gtgaccatga ggaagaagag agcagaccct
      961 gtggatcctg tggaccttat ggatccagtg tga
//
LOCUS       NM_001105949             953 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus complement C1q like 2 (C1ql2), mRNA.
ACCESSION   NM_001105949 XM_001054566 XM_222564
VERSION     NM_001105949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474028.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001054566.1, XM_222564.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..953
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /note="complement C1q like 2"
                     /db_xref="GeneID:288979"
                     /db_xref="RGD:1594583"
     exon            1..773
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..953
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /note="complement C1q-like protein 2; complement component
                     1, q subcomponent-like 2; adiponectin i"
                     /codon_start=1
                     /product="complement C1q-like protein 2 precursor"
                     /protein_id="NP_001099419.1"
                     /db_xref="GeneID:288979"
                     /db_xref="RGD:1594583"
                     /translation="MALGLLIAVPLLLQAAPPGAAHYEMLGTCRMICDPYTVSPAGGP
                     AGAKAPPPGPSTAALEVMQDLSANPPPPFIQGPKGDPGRPGKPGPRGPPGEPGPPGPR
                     GPPGEKGDSGRPGLPGLQLTTSAAGGVGVVGGGTGGGGDTEGEVTSALSAAFSGPKIA
                     FYVGLKSPHEGYEVLKFDDVVTNLGNHYDPTTGKFSCQVRGIYFFTYHILMRGGDGTS
                     MWADLCKNGQVRASAIAQDADQNYDYASNSVVLHLDSGDEVYVKLDGGKAHGGNNNKY
                     STFSGFLLYPD"
     sig_peptide     90..152
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    567..941
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     misc_feature    567..941
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /note="C1q domain; Region: C1q; pfam00386"
                     /db_xref="CDD:395310"
     exon            774..953
                     /gene="C1ql2"
                     /gene_synonym="Adii"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcaagga ggagctggtg gcggtcgcct cccggctgtg gcagcggcgg cggcgcgcct
       61 gcttggcggc cgtcggcgtg ctcctggcca tggcactggg gctgctaatc gcggtgcctc
      121 tgctactgca ggcggcgccc ccaggagcgg ctcactacga gatgctgggc acctgccgca
      181 tgatctgtga cccgtacacc gtctctcccg cagggggacc cgcgggcgcc aaggctccac
      241 cgcccgggcc cagtaccgct gccctggaag ttatgcagga cctcagcgcc aaccccccgc
      301 ctccgtttat ccagggacca aagggtgatc cgggccgacc aggcaagccc gggcctcggg
      361 gtcctcctgg agagccaggg cctcctggac ccaggggtcc cccgggagag aagggagact
      421 cggggaggcc agggctaccc ggactgcagt tgacaactag cgcagccggt ggcgttggtg
      481 tggtgggtgg cggaaccggg ggcggtggtg acacagaggg agaagtgacc agtgcgctga
      541 gtgctgcctt cagcggtccc aagattgcct tctacgtggg actcaagagc ccccacgaag
      601 gttacgaggt gctcaagttc gacgacgtgg tcaccaatct tggcaatcac tacgacccca
      661 ctaccggcaa gttcagctgc caggtgcggg gcatctactt cttcacgtac cacatcctca
      721 tgcgtggcgg cgacggaacc agcatgtggg cggatctctg caagaacggg caggtgcgtg
      781 ccagcgccat agcccaggac gcggaccaga attatgacta cgccagcaac agcgtggtcc
      841 tgcacctgga ttcgggcgat gaggtctatg tgaagttgga cggcgggaag gcgcacgggg
      901 gcaacaacaa caagtacagc acgttctcgg gctttctcct gtatccggat tag
//
LOCUS       NM_001013413            5068 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus alsin Rho guanine nucleotide exchange factor ALS2
            (Als2), mRNA.
ACCESSION   NM_001013413 XM_001061827 XM_001064519 XM_001064573 XM_343574
VERSION     NM_001013413.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5068)
  AUTHORS   Masutani,T., Taguchi,K., Kumanogoh,H., Nakamura,S. and Maekawa,S.
  TITLE     Molecular interaction of neurocalcin alpha with alsin (ALS2)
  JOURNAL   Neurosci Lett 438 (1), 26-28 (2008)
   PUBMED   18482800
  REMARK    GeneRIF: These results suggest that alsin binds cell membrane in a
            Ca(2+)-dependent manner through NCalpha and regulates membrane
            dynamics.
REFERENCE   2  (bases 1 to 5068)
  AUTHORS   Suzuki-Utsunomiya,K., Hadano,S., Otomo,A., Kunita,R., Mizumura,H.,
            Osuga,H. and Ikeda,J.E.
  TITLE     ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome
            dynamics
  JOURNAL   Biochem Biophys Res Commun 354 (2), 491-497 (2007)
   PUBMED   17239822
REFERENCE   3  (bases 1 to 5068)
  AUTHORS   Lai,C., Xie,C., McCormack,S.G., Chiang,H.C., Michalak,M.K., Lin,X.,
            Chandran,J., Shim,H., Shimoji,M., Cookson,M.R., Huganir,R.L.,
            Rothstein,J.D., Price,D.L., Wong,P.C., Martin,L.J., Zhu,J.J. and
            Cai,H.
  TITLE     Amyotrophic lateral sclerosis 2-deficiency leads to neuronal
            degeneration in amyotrophic lateral sclerosis through altered AMPA
            receptor trafficking
  JOURNAL   J Neurosci 26 (45), 11798-11806 (2006)
   PUBMED   17093100
REFERENCE   4  (bases 1 to 5068)
  AUTHORS   Jacquier,A., Buhler,E., Schafer,M.K., Bohl,D., Blanchard,S.,
            Beclin,C. and Haase,G.
  TITLE     Alsin/Rac1 signaling controls survival and growth of spinal
            motoneurons
  JOURNAL   Ann Neurol 60 (1), 105-117 (2006)
   PUBMED   16802292
REFERENCE   5  (bases 1 to 5068)
  AUTHORS   Devon,R.S., Orban,P.C., Gerrow,K., Barbieri,M.A., Schwab,C.,
            Cao,L.P., Helm,J.R., Bissada,N., Cruz-Aguado,R., Davidson,T.L.,
            Witmer,J., Metzler,M., Lam,C.K., Tetzlaff,W., Simpson,E.M.,
            McCaffery,J.M., El-Husseini,A.E., Leavitt,B.R. and Hayden,M.R.
  TITLE     Als2-deficient mice exhibit disturbances in endosome trafficking
            associated with motor behavioral abnormalities
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9595-9600 (2006)
   PUBMED   16769894
REFERENCE   6  (bases 1 to 5068)
  AUTHORS   Bros,V., Shemilt,S.J., Cooper,J.D., Skaper,S.D., Leigh,P.N. and
            Gallo,J.M.
  TITLE     A novel somatodendritic marker defined by a peptide derived from
            the ALS2 protein
  JOURNAL   Neuroreport 15 (14), 2155-2159 (2004)
   PUBMED   15371724
REFERENCE   7  (bases 1 to 5068)
  AUTHORS   Kunita,R., Otomo,A., Mizumura,H., Suzuki,K., Showguchi-Miyata,J.,
            Yanagisawa,Y., Hadano,S. and Ikeda,J.E.
  TITLE     Homo-oligomerization of ALS2 through its unique carboxyl-terminal
            regions is essential for the ALS2-associated Rab5 guanine
            nucleotide exchange activity and its regulatory function on
            endosome trafficking
  JOURNAL   J Biol Chem 279 (37), 38626-38635 (2004)
   PUBMED   15247254
REFERENCE   8  (bases 1 to 5068)
  AUTHORS   Topp,J.D., Gray,N.W., Gerard,R.D. and Horazdovsky,B.F.
  TITLE     Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 279 (23), 24612-24623 (2004)
   PUBMED   15033976
  REMARK    GeneRIF: Als2 gene encodes a large protein termed alsin, which
            contains a number of predicted cell signaling and protein
            trafficking sequence motifs.
REFERENCE   9  (bases 1 to 5068)
  AUTHORS   Otomo,A., Hadano,S., Okada,T., Mizumura,H., Kunita,R.,
            Nishijima,H., Showguchi-Miyata,J., Yanagisawa,Y., Kohiki,E.,
            Suga,E., Yasuda,M., Osuga,H., Nishimoto,T., Narumiya,S. and
            Ikeda,J.E.
  TITLE     ALS2, a novel guanine nucleotide exchange factor for the small
            GTPase Rab5, is implicated in endosomal dynamics
  JOURNAL   Hum Mol Genet 12 (14), 1671-1687 (2003)
   PUBMED   12837691
REFERENCE   10 (bases 1 to 5068)
  AUTHORS   Yang,Y., Hentati,A., Deng,H.X., Dabbagh,O., Sasaki,T., Hirano,M.,
            Hung,W.Y., Ouahchi,K., Yan,J., Azim,A.C., Cole,N., Gascon,G.,
            Yagmour,A., Ben-Hamida,M., Pericak-Vance,M., Hentati,F. and
            Siddique,T.
  TITLE     The gene encoding alsin, a protein with three guanine-nucleotide
            exchange factor domains, is mutated in a form of recessive
            amyotrophic lateral sclerosis
  JOURNAL   Nat Genet 29 (2), 160-165 (2001)
   PUBMED   11586297
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK005190.1.
            
            On or before Feb 3, 2007 this sequence version replaced
            XM_343574.3, XM_001061827.1, XM_001064519.1, XM_001064573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..5068
                     /gene="Als2"
                     /note="alsin Rho guanine nucleotide exchange factor ALS2"
                     /db_xref="GeneID:363235"
                     /db_xref="RGD:1310372"
     exon            1..54
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..132
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Als2"
                     /note="upstream in-frame stop codon"
     CDS             113..5068
                     /gene="Als2"
                     /note="amyotrophic lateral sclerosis protein 2 homolog;
                     ALS2, alsin Rho guanine nucleotide exchange factor;
                     amyotrophic lateral sclerosis 2 protein homolog;
                     amyotrophic lateral sclerosis 2 (juvenile)"
                     /codon_start=1
                     /product="alsin"
                     /protein_id="NP_001013431.1"
                     /db_xref="GeneID:363235"
                     /db_xref="RGD:1310372"
                     /translation="MDSKKKSSAEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVL
                     QAALGVKHGVLLTEDGEVYSFGTLPWKSEAAEICPSSPLLESALVGHHVVTVATGSFH
                     SGAVTESGVVYMWGENAAGQCAVANQQYVSEPSPVSISDSETSPLLAVRILQLACGEE
                     HTLALSISREIWAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ
                     CLPPQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLSESQAEKHASTVT
                     SPHPETLDGQGEVFENTVAEAELNMGSDQTTSGSAISAQQNIVGMAEVSSARTAPSYP
                     DTQTVTAYLQKLSEHSVKENHEREEKLPQVQPLVEEAVPDLHSPPTTSTSALNSLVVS
                     CASAVGVRVAATYEAGALSLKKVMNFYSTAPCEPGAPSGTASTGPESLKDLREEQVKQ
                     ESLQGKKSSSLMDIREEESEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYS
                     GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSL
                     ALTAKSQVYSWGSNTFGQLGHSEFPTTVPRLSKVSSESGVWSVAAGHGYSLFLVDTED
                     FQPGLYYSGRQDRAEGDTLPENPSGTTTPVLLSCSKLGYISRVTAGKDSYLALVDKNI
                     MGYIASLHELATTERRFYSKLSEIKSQILRPLLSLEHLGTVTTVQLLQEVASRFSKLC
                     YLIGQHGASLSSYLQGMKEARNLVIMKHSSLFLDSYTEYCTSVSNFLVMGGSQLLAKP
                     AIDFLNKNQELLQDLSEVNDENTQLMEILNALFFLPIRRLHNYAKVLLKLATCFEVTS
                     PEYQKLQDSSSCYESLALHLGKKRKEAEYTLSFWKTFPGKMTDSLRKPERRLLCESSN
                     RALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEETGGVNGLKITT
                     PEEQFTLISSTPQEKTKWLRAISQAVDQALRGTSDFPLYGGSSTVQRQEPPISRSAKY
                     TFYKDTRLKDATYDGRWLSGKPHGRGVLKWPDGKVYSGTFRNGLEDGYGEYRIPNKAL
                     NKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFI
                     GQWVMDKKAGYGVFDDITRGEKYMGMWQDDACQGNGVVVTQFGLYYEGNFHLNKMMGN
                     GVLLSEDDTIYEGEFSDDWTLCGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSL
                     YESDKDRPKAFRKLGNLAVAADEKWRAVFDECWRQLGCESPGQGEVWKAWDNIAVALT
                     TNRRQHKDSPEILSRSQTQTLESLEYIPQHVGAFSVEKYDDIKKYLIKACDTPLHPLG
                     RLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTVPL
                     SAPLPTGRRSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE
                     EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPSTKDACFASAVEC
                     LQQISTTFTPSDKLKVIQQTFEEISQSVLASLQEDFLWSMDDLFPVFLYVVLRARIRN
                     LGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN"
     misc_feature    <164..769
                     /gene="Als2"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; Region:
                     ATS1; COG5184"
                     /db_xref="CDD:444065"
     misc_feature    <164..769
                     /gene="Als2"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; Region:
                     ATS1; COG5184"
                     /db_xref="CDD:444065"
     misc_feature    287..436
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: RCC1 1"
     misc_feature    437..613
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: RCC1 2"
     misc_feature    617..766
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: RCC1 3"
     misc_feature    1442..1540
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1487..1489
                     /gene="Als2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96Q42; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Als2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96Q42; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    1541..1543
                     /gene="Als2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    1568..1570
                     /gene="Als2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    1622..1624
                     /gene="Als2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    1667..1822
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: RCC1 4"
     misc_feature    1676..>1978
                     /gene="Als2"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; Region:
                     ATS1; COG5184"
                     /db_xref="CDD:444065"
     misc_feature    1676..>1978
                     /gene="Als2"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; Region:
                     ATS1; COG5184"
                     /db_xref="CDD:444065"
     misc_feature    1691..1693
                     /gene="Als2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96Q42; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); acetylation site"
     misc_feature    1826..1975
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: RCC1 5"
     misc_feature    2177..2731
                     /gene="Als2"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571"
                     /db_xref="CDD:470622"
     misc_feature    2177..2731
                     /gene="Als2"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571"
                     /db_xref="CDD:470622"
     misc_feature    order(2183..2185,2195..2197,2498..2500,2594..2599,
                     2606..2611,2615..2620,2627..2632,2642..2647,2729..2731)
                     /gene="Als2"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238091"
     misc_feature    order(2183..2185,2195..2197,2498..2500,2594..2599,
                     2606..2611,2615..2620,2627..2632,2642..2647,2729..2731)
                     /gene="Als2"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238091"
     misc_feature    2807..3124
                     /gene="Als2"
                     /note="Alsin Pleckstrin homology (PH) domain; Region:
                     PH_alsin; cd13269"
                     /db_xref="CDD:241423"
     misc_feature    2807..3124
                     /gene="Als2"
                     /note="Alsin Pleckstrin homology (PH) domain; Region:
                     PH_alsin; cd13269"
                     /db_xref="CDD:241423"
     misc_feature    <3146..3841
                     /gene="Als2"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    <3146..3841
                     /gene="Als2"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG4642"
                     /db_xref="CDD:443680"
     misc_feature    3239..3307
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 1"
     misc_feature    3308..3376
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 2"
     misc_feature    3392..3460
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 3"
     misc_feature    3461..3529
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 4"
     misc_feature    3545..3613
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 5"
     misc_feature    3617..3685
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 6"
     misc_feature    3686..3754
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 7"
     misc_feature    3755..3826
                     /gene="Als2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5Y8.1);
                     Region: MORN 8"
     misc_feature    4097..4099
                     /gene="Als2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P0C5Y8.1); phosphorylation site"
     misc_feature    4748..5062
                     /gene="Als2"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     misc_feature    4748..5062
                     /gene="Als2"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     exon            133..287
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..1207
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1565
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1734
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1831
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1909
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2092
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2264
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2445
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2511
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2674
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2806
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2935
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3006
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3073
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3276
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3342
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3441
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3606
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3718
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3796
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3930
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4098
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4216
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4374
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4497
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4674
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4720
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4782
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4932
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            4933..5029
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5068
                     /gene="Als2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgcagt cgggctcgcg ccgggcgaag agcgcggagc tgcgggagcg tcaggttttg
       61 agagagcttc tgctaatgga atgatttggt gatggagtat tcctcctgac cgatggactc
      121 aaagaagaaa agctcagcag aggcagaagg atccaaagaa agaggcctag tccatgtctg
      181 gcaggcagga tccttttctc taacaccaga gaggttgcca ggctggggag gaaaaacagt
      241 tcttcaggcg gcccttggcg tgaagcatgg agttcttctg actgaagatg gtgaggtcta
      301 cagctttggg acccttccct ggaaaagtga agcagcagaa atttgtccaa gcagccccct
      361 tctagaaagt gccctggttg ggcatcatgt tgttactgtg gcaacaggga gcttccacag
      421 tggagcggtg acagaaagtg gagtggtgta catgtggggg gagaacgctg ccgggcagtg
      481 tgcagtagcg aaccagcagt atgtgtcgga accaagtcct gtcagcattt ctgactcgga
      541 gaccagcccc ttgctagcag ttaggattct gcagttggca tgtggcgagg aacacacact
      601 ggcattgtca atcagcagag agatctgggc atggggcacc ggctgtcagc tgggtctcat
      661 caccaccacc ttcccagtga caaagccaca aaaggtggaa caccttgctg gacgagtggt
      721 gctccaggtg gcctgtggtg cgttccacag ccttgcactt gtgcagtgcc tccctcccca
      781 ggatctgaag ccagtcccag agagatgcaa tcagtgcagc cagctgctca tcaccatgac
      841 agacaaagag gaccacgtga taatatcaga cagccattgc tgccctttag gtgtgacact
      901 gtctgaatct caagcagaaa agcacgccag cactgtgacc agccctcacc cggagacgct
      961 ggatgggcaa ggagaggtgt ttgagaacac agtagcagaa gctgaactga atatgggaag
     1021 cgatcagacc acaagtggca gtgccatttc cgcccagcag aacatcgtgg gaatggctga
     1081 agtgtcttct gccagaacag ctccctcata cccagacacc cagacggtaa ctgcatacct
     1141 gcagaagcta tcagagcatt cagtgaagga gaaccatgag cgtgaggaaa agctacccca
     1201 ggtccagcct cttgtagaag aagcagttcc tgatcttcac agtccaccaa ccacaagcac
     1261 ctcagccctc aacagcttgg tggtctcctg tgcatctgct gttggtgtga gagtggccgc
     1321 cacctatgaa gctggggcct tgtctctcaa gaaagttatg aacttttata gcactgcccc
     1381 ctgcgagcca ggagctccgt caggcactgc ctccacaggc ccagaaagtc tgaaagatct
     1441 cagagaagag caggtgaaac aggaatcact acaagggaag aaaagctcaa gcctcatgga
     1501 tatcagagag gaggagtcgg agggagggag tcgaagactc tccctcccag gattgttgtc
     1561 gcaagtttcc cccaggctct taaggaaggc cgccagggtg aaaacacgga cagtggttct
     1621 gactcccacg tacagtggag aagcagatgc cctcctgcct tcgctgagaa cagaggtgtg
     1681 gacctggggg aaaggcaagg aagggcagct ggggcacggc gatgtcctgc ccaggcttca
     1741 gccgttgtgt gtcaagtgtc tggatggtaa agaggtcatc cacttggagg caggtggctc
     1801 ccactctctc gcactgactg cgaaatctca ggtttactca tggggcagta ataccttcgg
     1861 tcagctgggg cattctgagt ttccaacaac ggttcctcga ctctcgaagg ttagcagtga
     1921 aagtggagtc tggagtgtag ctgcaggcca cggttattcc ctgtttttag tggacactga
     1981 agacttccag cctgggttgt attacagtgg ccgccaggac cgtgcagaag gtgacaccct
     2041 gccagagaat cccagtggta caacgactcc ggtacttctc tcctgtagta agcttggata
     2101 tatcagcaga gtgacagcag gaaaagatag ctacctagcc ttggtggata agaacatcat
     2161 gggatacatc gccagcctcc atgagttggc taccacagaa agacggtttt actcgaaact
     2221 aagtgaaatc aagtcacaga tacttaggcc tcttctcagt ctggaacatt tgggcactgt
     2281 gaccactgtc cagctgttgc aggaagtcgc cagccggttc agcaagttgt gttacctcat
     2341 tgggcagcat ggagcctcac tgagcagcta cctgcaaggc atgaaggaag ccaggaacct
     2401 ggtcatcatg aagcactcga gtcttttctt ggacagttac acagagtatt gtacatcagt
     2461 ttcaaatttt ctggttatgg gaggatccca gcttcttgct aagcctgcaa ttgatttcct
     2521 aaataaaaac caagaactct tgcaagattt gtcagaagtg aatgatgaga acactcagtt
     2581 gatggaaata ctgaatgcgc tgtttttctt gccaatcaga cgacttcata attatgcaaa
     2641 agttttgcta aagctcgcca cttgctttga agtgacatca ccagagtatc aaaagctgca
     2701 ggattccagt tcttgttatg agtctcttgc tctccatctt ggcaagaaga ggaaggaagc
     2761 agagtacacg ctgagcttct ggaagacctt ccctggaaaa atgacggatt ccttgaggaa
     2821 gccagagcgc cggctgctgt gtgagagcag taaccgagcc ctctccctgc agcatgctgg
     2881 caggttttct gtgaattggt tcattctctt caatgatgcc ctggtccatg ctcagttctc
     2941 cacacaccac gtgttccctt tggccacact ctgggcagag ccactttctg aagaaactgg
     3001 tggcgtgaat ggcttaaaga taaccacacc tgaagaacag ttcacgctca tttcttcaac
     3061 accccaggaa aagaccaagt ggcttcgggc tatcagccaa gccgtggacc aggctttgag
     3121 ggggacgtct gacttcccac tttacggagg cagcagcact gttcagaggc aggaaccacc
     3181 catctcaaga agtgccaaat acactttcta caaggatact cgcctaaagg acgccactta
     3241 cgatgggcgc tggctttcag ggaagccgca cggaaggggt gttttgaagt ggcctgatgg
     3301 gaaggtgtat tctggcacgt tcaggaatgg cttggaagac ggatatggtg aatacagaat
     3361 cccaaacaag gccctgaaca aagaagacca ttacgtgggc cattggaagg aggggaaaat
     3421 gtgtgggcaa ggagtgtaca gctatgcctc tggtgaagtg tttgaaggct gctttcaaga
     3481 taacatgcgc cacgggcacg gtctcctccg cagtggaaaa ctgacttctt cctctcccag
     3541 catgttcatt ggccagtggg taatggacaa gaaagcaggg tatggcgtct tcgatgatat
     3601 caccagggga gaaaagtaca tgggaatgtg gcaggacgat gcatgccaag ggaatggggt
     3661 ggtggtcacc cagtttgggt tatactacga aggcaacttc caccttaata aaatgatggg
     3721 aaatggggtt ttgctttcgg aagatgatac tatatatgaa ggagaatttt ctgatgactg
     3781 gacactttgt ggaaagggaa cactgactat gccaaatgga gattatattg aaggttattt
     3841 tagtggagaa tggggatctg ggataaaaat cactgggacc tacttcaaac ctagcctata
     3901 tgagagtgat aaggacaggc ccaaagcctt caggaagctg ggaaacctgg ccgtggccgc
     3961 cgatgagaaa tggagagcag tgtttgacga atgctggcgc cagctgggct gtgagagccc
     4021 aggccaaggg gaggtttgga aagcgtggga taatattgct gtggccttga ccaccaaccg
     4081 tcgccagcat aaagacagtc cagaaatact aagccgttca cagactcaga ccctggagag
     4141 tttggagtac attccccagc acgttggcgc cttctctgtg gagaaatatg atgatatcaa
     4201 gaagtattta ataaaggcct gtgacactcc tctgcaccca ctgggcaggc ttgtggagac
     4261 cctggttgca gtgtatagaa tgacttatgt gggcgtaggg gccaaccgtc ggttactgca
     4321 ggaagctgtg aaggagatta agtcttatct caagaggatt ttccaacttg tgaggttctt
     4381 gtttcctgag cttcctgaag agggcagcac agttcctctc tctgctcctc tgcccactgg
     4441 aagaagatcc ttctgcactg ggaaatcaga ttccagatcc gagtcaccag agccaggtta
     4501 tgtagtaaca agttctggct tactgcttcc ggtgctgctg cctcggctct acccgcctct
     4561 cttcatgctc tatgccctgg acaatgaccg agaggaagac atttactggg aatgtgtgct
     4621 tcgactaaac aagcagccag atattgctct cctgggcttt cttggagtac agaggaaatt
     4681 ctggccagca accttgtcaa tccttggaga gagtaaaaag gtactgccat ccacaaagga
     4741 tgcttgtttt gcatctgcag tagaatgtct gcagcagatc agcacaacat ttactccatc
     4801 agacaaactt aaagtgatcc agcagacctt cgaagaaatc tctcagagtg tgctggcgtc
     4861 gctgcaggag gacttccttt ggtccatgga tgacttgttc cctgtcttct tatacgtggt
     4921 gctgcgggcc aggattcgga atttaggctc tgaagttcat ctcattgagg atctgatgga
     4981 cccctatctc cagcatgggg agcaaggcat aatgttcacc accttgaagg cctgttacta
     5041 ccagattcag cgtgagaagc ttaactag
//
LOCUS       NM_001106941            2125 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAGE family member E2 (Magee2), mRNA.
ACCESSION   NM_001106941 XM_001056951 XM_228532
VERSION     NM_001106941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473969.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228532.3, XM_001056951.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2125
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="MAGE family member E2"
                     /db_xref="GeneID:302392"
                     /db_xref="RGD:1564872"
     exon            1..2125
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    120..122
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="upstream in-frame stop codon"
     CDS             216..1787
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="melanoma antigen, family E, 2"
                     /codon_start=1
                     /product="melanoma-associated antigen E2"
                     /protein_id="NP_001100411.1"
                     /db_xref="GeneID:302392"
                     /db_xref="RGD:1564872"
                     /translation="MSVVSQNARQGRAETTADYSDSQGEMQATNASGPPNSMLVPEAA
                     QGLEIPDDPQGASAPQAAQDPRDIEVLIDEQSRRLGALRVHDPLEERSVALVNFLRMK
                     SQSEGSIRQSEMLEFLNEYSDQFPEILRRASAYLDRVFGLNLRVLDPQTDTYNLISKP
                     GPQTTERLAETLDMPKAGLLALVLGHILLNGNRAREASIWDLLLKVEVIDETQRINNL
                     FGNTRNLLTTDFVQMRFLEYWPVYGTNPLEFEFLWGSRAHREITKMEALKFIAEAHDE
                     EPWSWPEEYNKALESDKAKERSQAAGLEFWSEDTMNDKANDVVQLAINGTEELLPIHQ
                     DELLAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDASDHIYLLVPQPESEEEQVM
                     LESLGRPTHEYMMPILGLIFLMGNRVKEAKIWNLLRRFNVDVGRKHAITCKLMRQRYL
                     ECRPLSYSNPVEYELLWGPRAHLEITKMKALEYMARLYRKQPQDWPEQYREAVEDEEA
                     RARSEATAMFFFGSM"
     misc_feature    498..1007
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     misc_feature    498..1007
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     misc_feature    1260..1649
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
     misc_feature    1260..1649
                     /gene="Magee2"
                     /gene_synonym="RGD1564872"
                     /note="MAGE homology domain; Region: MAGE; pfam01454"
                     /db_xref="CDD:426270"
ORIGIN      
        1 gagtgcgcct gcgtaggatg cggcaaagct aggttcttag gttttccttc tttgctgatt
       61 actgcttgtg tataaagatc gcctttctca ccagctctcc ctttcgaacc gcacagctct
      121 gagtgtcagg cttcggctct gtgccgaggt gccaacacac tcctccctcc gacggattgc
      181 tgacctccac gttcgcgttc ctgtctcctg gaaccatgtc tgtggtaagc cagaatgcgc
      241 gccaaggcag agcagagacc actgcagatt acagcgacag ccagggtgaa atgcaggcta
      301 ctaatgcctc tgggcccccc aactccatgc tagtccccga ggctgcccag ggccttgaga
      361 ttccagacga tccacagggt gccagcgctc cccaggctgc gcaggacccg agagacatcg
      421 aggttctcat cgacgagcag tcccgacgtt tgggggcgct cagggtccat gaccctttag
      481 aagagaggtc ggttgcttta gtgaatttct tgcgaatgaa aagtcaaagt gaggggtcta
      541 tccgacagtc agaaatgttg gagtttctca atgaatactc agatcagttc cctgagatac
      601 tcagacgagc ctcagcttat ctggaccggg tctttgggtt gaatctgaga gtccttgatc
      661 ctcagaccga cacttacaat ctaatcagca aaccgggtcc ccagaccact gaacgcctag
      721 cagagaccct ggacatgcca aaagcaggtc ttctggcctt ggtcctcggc cacatcctct
      781 tgaatggcaa ccgggcaaga gaggcctcca tctgggacct gctgttaaag gtagaagtga
      841 tagatgaaac tcagaggatc aacaacctct ttgggaacac aagaaacctc ctcactacgg
      901 actttgtcca gatgcgattt ttggagtact ggccggtata tggcactaat cccctcgaat
      961 ttgagttcct gtggggctct agagcccaca gagaaatcac gaagatggaa gccctgaagt
     1021 ttatagcaga agctcatgat gaagaaccct ggagctggcc agaagaatat aacaaagctc
     1081 tggaatctga taaggccaaa gagagaagcc aggctgccgg cttagagttc tggtcagagg
     1141 acactatgaa tgataaagca aatgatgtgg tccagttggc tattaatggc actgaggaat
     1201 tgctgcctat ccatcaggat gagctattgg ctcacactgg caaagaattc gaggatgtgt
     1261 tcccaaatat cctcagccga gccacgctaa tccttgatct gttttatggc ttctctctga
     1321 ttgaggttga tgccagtgat cacatctacc tccttgtccc gcaaccagaa tcagaagaag
     1381 agcaagtaat gctagagagc ctgggcagac ccacccacga atacatgatg ccaatcctgg
     1441 gtttgatctt cctgatgggc aaccgtgtca aagaggccaa gatctggaac ttactccgga
     1501 gatttaatgt tgatgtaggg aggaaacatg ccattacctg taagctaatg aggcaacgct
     1561 acctagaatg caggccgctc tcctactcta atccagttga atacgagctg ctctggggtc
     1621 ctcgggctca ccttgaaatc accaaaatga aagccttgga atatatggct aggctctaca
     1681 gaaagcagcc acaggactgg ccagagcaat acagggaggc tgtggaagat gaggaggcca
     1741 gggccagatc tgaggcaaca gccatgttct tctttggttc catgtgaggt ctgatgttca
     1801 actttacttg agtggcatct gttaaaaggg cctttgggaa atgggaaatg ggcactcggg
     1861 ttctaaatca aaagttggga gggttggggt aaagagtaca ccttgtattt attatgttcc
     1921 aattctaata acatttcttt ccttctggta tactctttaa ttgtcttcac aatcagtgtt
     1981 ttttaaaatg aaattgcttg ttttctcttc ctgtcttgtt tcagtataaa agttcagata
     2041 gccgtgtaaa atgtattgta aaatgtattg tgttacatat ttgaaataac tagtaaaata
     2101 aggtaaataa cggtaaacac acaca
//
LOCUS       NM_001024685             996 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 138 (Tas2r138),
            mRNA.
ACCESSION   NM_001024685 XM_575442
VERSION     NM_001024685.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 996)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   2  (bases 1 to 996)
  AUTHORS   Wu,S.V., Chen,M.C. and Rozengurt,E.
  TITLE     Genomic organization, expression, and function of bitter taste
            receptors (T2R) in mouse and rat
  JOURNAL   Physiol Genomics 22 (2), 139-149 (2005)
   PUBMED   15886333
REFERENCE   3  (bases 1 to 996)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362746.1.
            
            On Jun 9, 2005 this sequence version replaced XM_575442.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY916512.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..996
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="taste receptor, type 2, member 138"
                     /db_xref="GeneID:500091"
                     /db_xref="RGD:1560649"
     CDS             1..996
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="T2R26; taste receptor type 2 member 26; taste
                     receptor, type 2, member 38"
                     /codon_start=1
                     /product="taste receptor type 2 member 38"
                     /protein_id="NP_001019856.1"
                     /db_xref="GeneID:500091"
                     /db_xref="RGD:1560649"
                     /translation="MLTLTPVLTVSYEAKISFLFLSVVEFAVGIMANAFIVLVNFWDM
                     VKKQPLNNCDIALLCLSITRLFLQGLLLLDAIQLACFQQMKDPLSHNYQAILTLWMIA
                     NQVSLWLAACLSLLYCAKIVRFSHTFPLHLASWVSRRFLQMLLVALLFSGVCTALCLW
                     DFFSRSHTVVTSMLHMNNTEFNLQIEKLNFFYSFVFCNVGSVPPSLVFLISSGVLVIS
                     LGNHMRTMKSQTRGSRDPSLEAHVRAIIFLVSFLCFYVVSFCAALISIPLLVLWHNKG
                     GVMVCIGMMAACPSGHAAILISGNAKLKKVIVTILFWFQSRQKVRRVHKVLPRIL"
     misc_feature    46..924
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="mammalian taste receptor 2, subtype 38, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R38; cd15025"
                     /db_xref="CDD:320153"
     misc_feature    46..924
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="mammalian taste receptor 2, subtype 38, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R38; cd15025"
                     /db_xref="CDD:320153"
     misc_feature    49..126
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320153"
     misc_feature    49..126
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320153"
     misc_feature    52..114
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    160..234
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320153"
     misc_feature    160..234
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320153"
     misc_feature    163..225
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    277..345
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320153"
     misc_feature    277..345
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320153"
     misc_feature    283..345
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    424..474
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320153"
     misc_feature    424..474
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320153"
     misc_feature    427..489
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    529..531
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4VHE7.1); glycosylation site"
     misc_feature    568..639
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320153"
     misc_feature    568..639
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320153"
     misc_feature    595..657
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    712..789
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320153"
     misc_feature    712..789
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320153"
     misc_feature    730..792
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     misc_feature    823..900
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320153"
     misc_feature    823..900
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320153"
     misc_feature    829..891
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4VHE7.1);
                     transmembrane region"
     exon            1..996
                     /gene="Tas2r138"
                     /gene_synonym="T2R38; Tas2r38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttgactc tgactcccgt cttaactgtg tcctatgaag ccaagatttc attcctgttc
       61 ctttccgtgg tggagtttgc agtgggaatc atggccaatg ccttcattgt cttggtaaac
      121 ttttgggaca tggtaaaaaa gcagccgttg aacaactgtg acatcgcact gctttgtctc
      181 agcatcaccc ggcttttcct gcagggcctt ctccttctgg atgctatcca gcttgcctgc
      241 ttccagcaga tgaaagaccc actaagccac aactaccaag ccatcctcac tctctggatg
      301 atcgcaaacc aagtgagcct ctggcttgct gcctgcctca gtctcctcta ctgcgccaag
      361 attgtccgtt tctctcacac cttcccactt cacttagcaa gctgggtctc cagaagattt
      421 ctccagatgc ttctagttgc tcttcttttc tccggcgtct gcactgccct ctgtttgtgg
      481 gactttttta gcagatctca caccgtggtc acatccatgt tgcacatgaa caacacagaa
      541 ttcaatctgc aaattgaaaa actcaatttc ttttactcgt ttgtcttctg caatgtgggc
      601 tctgtgcccc cttctctagt tttcttgatt tcctccggag tgctggttat ctccctggga
      661 aatcacatga gaactatgaa gtcccaaacc agaggctctc gtgaccccag ccttgaggcc
      721 catgtcagag ccatcatatt tctggtctcc tttctctgtt tttatgtggt gtcattctgt
      781 gccgctttaa tatcaatacc cttactggta ctgtggcaca ataagggagg agtgatggtc
      841 tgtataggga tgatggcagc ctgcccttct ggacatgcag ccatcctgat atcaggcaat
      901 gccaagctga agaaggtcat agtgaccatt ctattctggt ttcaaagcag gcaaaaggtg
      961 agaagagtcc acaaggttct tcccaggata ctctga
//
LOCUS       NM_012616                551 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus olfactory marker protein (Omp), mRNA.
ACCESSION   NM_012616
VERSION     NM_012616.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 551)
  AUTHORS   Makeyeva,Y., Nicol,C., Ledger,W.L. and Ryugo,D.K.
  TITLE     Immunocytochemical Localization of Olfactory-signaling Molecules in
            Human and Rat Spermatozoa
  JOURNAL   J Histochem Cytochem 68 (7), 491-513 (2020)
   PUBMED   32603211
REFERENCE   2  (bases 1 to 551)
  AUTHORS   Sadrian,B., Cheng,T.W., Shull,O. and Gong,Q.
  TITLE     Rap1gap2 regulates axon outgrowth in olfactory sensory neurons
  JOURNAL   Mol Cell Neurosci 50 (3-4), 272-282 (2012)
   PUBMED   22732430
REFERENCE   3  (bases 1 to 551)
  AUTHORS   Choi,P.S., Zakhary,L., Choi,W.Y., Caron,S., Alvarez-Saavedra,E.,
            Miska,E.A., McManus,M., Harfe,B., Giraldez,A.J., Horvitz,H.R.,
            Schier,A.F. and Dulac,C.
  TITLE     Members of the miRNA-200 family regulate olfactory neurogenesis
  JOURNAL   Neuron 57 (1), 41-55 (2008)
   PUBMED   18184563
REFERENCE   4  (bases 1 to 551)
  AUTHORS   Fleischer,J., Schwarzenbacher,K., Besser,S., Hass,N. and Breer,H.
  TITLE     Olfactory receptors and signalling elements in the Grueneberg
            ganglion
  JOURNAL   J Neurochem 98 (2), 543-554 (2006)
   PUBMED   16805845
REFERENCE   5  (bases 1 to 551)
  AUTHORS   Yang,P., Baker,K.A. and Hagg,T.
  TITLE     A disintegrin and metalloprotease 21 (ADAM21) is associated with
            neurogenesis and axonal growth in developing and adult rodent CNS
  JOURNAL   J Comp Neurol 490 (2), 163-179 (2005)
   PUBMED   16052496
REFERENCE   6  (bases 1 to 551)
  AUTHORS   Buiakova,O.I., Baker,H., Scott,J.W., Farbman,A., Kream,R.,
            Grillo,M., Franzen,L., Richman,M., Davis,L.M., Abbondanzo,S.,
            Stewart,C.L. and Margolis,F.L.
  TITLE     Olfactory marker protein (OMP) gene deletion causes altered
            physiological activity of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9858-9863 (1996)
   PUBMED   8790421
REFERENCE   7  (bases 1 to 551)
  AUTHORS   Kudrycki,K., Stein-Izsak,C., Behn,C., Grillo,M., Akeson,R. and
            Margolis,F.L.
  TITLE     Olf-1-binding site: characterization of an olfactory
            neuron-specific promoter motif
  JOURNAL   Mol Cell Biol 13 (5), 3002-3014 (1993)
   PUBMED   8474458
REFERENCE   8  (bases 1 to 551)
  AUTHORS   Danciger,E., Mettling,C., Vidal,M., Morris,R. and Margolis,F.
  TITLE     Olfactory marker protein gene: its structure and olfactory
            neuron-specific expression in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8565-8569 (1989)
   PUBMED   2701951
REFERENCE   9  (bases 1 to 551)
  AUTHORS   Rogers,K.E., Dasgupta,P., Gubler,U., Grillo,M., Khew-Goodall,Y.S.
            and Margolis,F.L.
  TITLE     Molecular cloning and sequencing of a cDNA for olfactory marker
            protein
  JOURNAL   Proc Natl Acad Sci U S A 84 (6), 1704-1708 (1987)
   PUBMED   3470751
REFERENCE   10 (bases 1 to 551)
  AUTHORS   Sydor,W., Teitelbaum,Z., Blacher,R., Sun,S., Benz,W. and
            Margolis,F.L.
  TITLE     Amino acid sequence of a unique neuronal protein: rat olfactory
            marker protein
  JOURNAL   Arch Biochem Biophys 249 (2), 351-362 (1986)
   PUBMED   3753006
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M26926.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..551
                     /gene="Omp"
                     /note="olfactory marker protein"
                     /db_xref="GeneID:24612"
                     /db_xref="RGD:3231"
     exon            1..551
                     /gene="Omp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    3..5
                     /gene="Omp"
                     /note="upstream in-frame stop codon"
     CDS             60..551
                     /gene="Omp"
                     /note="olfactory neuronal-specific protein"
                     /codon_start=1
                     /product="olfactory marker protein"
                     /protein_id="NP_036748.1"
                     /db_xref="GeneID:24612"
                     /db_xref="RGD:3231"
                     /translation="MAEDGPQKQQLDMPLVLDQDLTKQMRLRVESLKQRGEKKQDGEK
                     LLRPAESVYRLDFIQQQKLQFDHWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDP
                     AAIFWRKEDSDAMDWNEADALEFGERLSDLAKIRKVMYFLITFGEGVEPANLKASVVF
                     NQL"
     misc_feature    63..65
                     /gene="Omp"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000269|PubMed:3753006; propagated from
                     UniProtKB/Swiss-Prot (P08523.2); acetylation site"
     misc_feature    93..542
                     /gene="Omp"
                     /note="Olfactory marker protein; Region: Olfactory_mark;
                     pfam06554"
                     /db_xref="CDD:399511"
     misc_feature    93..542
                     /gene="Omp"
                     /note="Olfactory marker protein; Region: Olfactory_mark;
                     pfam06554"
                     /db_xref="CDD:399511"
ORIGIN      
        1 cttgattccc tgacgtctgt ggcagtggtg gcagtggcaa cagctgtagc acttgggcca
       61 tggcagagga cgggccacag aagcagcagc tggatatgcc gctggttctg gaccaggacc
      121 tgactaagca gatgcggctc cgagtagaga gcctgaagca gcgcggggag aagaagcagg
      181 atggtgagaa gctgctccgg ccggctgagt ctgtctaccg ccttgatttc atccagcagc
      241 agaagctgca gttcgatcac tggaacgtgg ttctggacaa gccgggcaag gtcaccatca
      301 cgggcacctc gcagaactgg acgccagacc tcaccaacct catgacacgc cagctgctgg
      361 accctgctgc catcttctgg cgcaaggaag actccgatgc catggattgg aatgaggcag
      421 acgccctgga gtttggggag cgcctttctg acctggccaa gatccgcaag gtcatgtatt
      481 tcctcatcac ctttggcgag ggtgtggagc ccgccaacct aaaggcctct gtggtgttta
      541 accagctctg a
//
LOCUS       NM_001014786             579 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus interferon, alpha 5 (Ifna5), mRNA.
ACCESSION   NM_001014786 XM_216443
VERSION     NM_001014786.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 579)
  AUTHORS   Hu,G., Xue,J., Duan,H., Yang,Z., Gao,L., Luo,H., Mu,X. and Cui,S.
  TITLE     IFN-gamma induces IFN-alpha and IFN-beta expressions in cultured
            rat intestinal mucosa microvascular endothelial cells
  JOURNAL   Immunopharmacol Immunotoxicol 32 (4), 656-662 (2010)
   PUBMED   20214528
  REMARK    GeneRIF: IFN-gamma is able to activate rat intestinal mucous
            microvascular endothelial cells, thereby leading to upregulated
            expressions of IFN-alpha/beta.
REFERENCE   2  (bases 1 to 579)
  AUTHORS   van der Meide,P.H., Dijkema,R., Caspers,M., Vijverberg,K. and
            Schellekens,H.
  TITLE     Cloning, expression, and purification of rat IFN-alpha 1
  JOURNAL   Methods Enzymol 119, 441-453 (1986)
   PUBMED   3020354
REFERENCE   3  (bases 1 to 579)
  AUTHORS   Dijkema,R., Pouwels,P., de Reus,A. and Schellekens,H.
  TITLE     Structure and expression in Escherichia coli of a cloned rat
            interferon-alpha gene
  JOURNAL   Nucleic Acids Res 12 (2), 1227-1242 (1984)
   PUBMED   6320120
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X00336.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216443.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..579
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="interferon, alpha 5"
                     /db_xref="GeneID:298210"
                     /db_xref="RGD:1359312"
     CDS             1..579
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="interferon-alpha 1; interferon-alpha 1-like 1"
                     /codon_start=1
                     /product="interferon alpha-1 precursor"
                     /protein_id="NP_001014786.1"
                     /db_xref="GeneID:298210"
                     /db_xref="RGD:1359312"
                     /translation="MARLCAFLMSLVVVSYWSACCLGCDLPHTHNLRNKRVFTLLAQM
                     RRLSPVSCLKDRKYFGFPLEKVDGQQIQKAQAIPVLHELTQQILSLFTSKESSTAWDA
                     TLLDSFCNDLQQQLSGLQACLMQQVGVQESPLTQEDSLLAVREYFHRITVYLRENKHS
                     PCAWEVVKAEVWRALSSSANLMGRLREERNES"
     sig_peptide     1..69
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     70..576
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /product="interferon alpha-1"
                     /note="mature rat IFN"
     misc_feature    76..555
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="Interferon alpha/beta domain; Region: Interferon;
                     pfam00143"
                     /db_xref="CDD:459689"
     misc_feature    76..555
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="Interferon alpha/beta domain; Region: Interferon;
                     pfam00143"
                     /db_xref="CDD:459689"
     misc_feature    order(82..87,94..96,103..108,115..117,124..129,298..303,
                     307..312,316..321,328..330,337..342,349..354,361..363)
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="putative IFNAR-1 binding site [active]"
                     /db_xref="CDD:238047"
     misc_feature    order(82..87,94..96,103..108,115..117,124..129,298..303,
                     307..312,316..321,328..330,337..342,349..354,361..363)
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="putative IFNAR-1 binding site [active]"
                     /db_xref="CDD:238047"
     misc_feature    order(157..180,184..192,208..213,421..426,430..435,
                     442..447,451..456,463..480)
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="putative IFNAR-2 binding site [active]"
                     /db_xref="CDD:238047"
     misc_feature    order(157..180,184..192,208..213,421..426,430..435,
                     442..447,451..456,463..480)
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="putative IFNAR-2 binding site [active]"
                     /db_xref="CDD:238047"
     misc_feature    301..303
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="N-glycosylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238047"
     misc_feature    301..303
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="N-glycosylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238047"
     misc_feature    568..570
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:6320120; propagated from
                     UniProtKB/Swiss-Prot (P05011.1); glycosylation site"
     exon            1..579
                     /gene="Ifna5"
                     /gene_synonym="IFN-alpha1; Ifna1; Ifna1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctcggc tctgtgcttt cttgatgtcc ctggtggtgg tgagctactg gtcagcctgc
       61 tgtctaggat gtgacctgcc tcatactcat aacctcagga acaagagagt cttcacactc
      121 ctggcacaaa tgaggagact ctcccctgtc tcatgcctga aggacagaaa gtactttggg
      181 ttccctttgg agaaggtgga tggccagcag atccagaagg ctcaagctat ccctgtcctg
      241 catgagctga cccagcagat cctcagcctc ttcacatcaa aggagtcatc tactgcttgg
      301 gatgcaaccc tcctagactc attctgtaat gacctccagc agcagctgag tggtctgcaa
      361 gcctgtctga tgcagcaggt aggggtgcag gaatctcccc tgacccagga agactcccta
      421 ctggctgtga gggaatactt ccacagaatc actgtgtacc tgagagagaa taaacacagc
      481 ccctgtgcct gggaggtggt caaagcagaa gtctggagag ccctgtcttc ctcagccaac
      541 ttgatgggaa gactgagaga agaaagaaat gagtcctga
//
LOCUS       NM_133410                552 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RAP2B, member of RAS oncogene family (Rap2b),
            mRNA.
ACCESSION   NM_133410
VERSION     NM_133410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Monteiro,A.C., Sumagin,R., Rankin,C.R., Leoni,G., Mina,M.J.,
            Reiter,D.M., Stehle,T., Dermody,T.S., Schaefer,S.A., Hall,R.A.,
            Nusrat,A. and Parkos,C.A.
  TITLE     JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c
            and regulate epithelial barrier function
  JOURNAL   Mol Biol Cell 24 (18), 2849-2860 (2013)
   PUBMED   23885123
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   3  (bases 1 to 552)
  AUTHORS   Hussain,N.K., Hsin,H., Huganir,R.L. and Sheng,M.
  TITLE     MINK and TNIK differentially act on Rap2-mediated signal
            transduction to regulate neuronal structure and AMPA receptor
            function
  JOURNAL   J Neurosci 30 (44), 14786-14794 (2010)
   PUBMED   21048137
  REMARK    GeneRIF: MINK interaction with Rap2 plays a critical role in
            maintaining the morphological integrity of dendrites and synaptic
            transmission.
REFERENCE   4  (bases 1 to 552)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 552)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 552)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   7  (bases 1 to 552)
  AUTHORS   Canobbio,I., Trionfini,P., Guidetti,G.F., Balduini,C. and Torti,M.
  TITLE     Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts
            is promoted by palmitoylation at Cys176 and Cys177 and is required
            for efficient protein activation in human platelets
  JOURNAL   Cell Signal 20 (9), 1662-1670 (2008)
   PUBMED   18582561
REFERENCE   8  (bases 1 to 552)
  AUTHORS   Kukimoto-Niino,M., Takagi,T., Akasaka,R., Murayama,K.,
            Uchikubo-Kamo,T., Terada,T., Inoue,M., Watanabe,S., Tanaka,A.,
            Hayashizaki,Y., Kigawa,T., Shirouzu,M. and Yokoyama,S.
  TITLE     Crystal structure of the RUN domain of the RAP2-interacting protein
            x
  JOURNAL   J Biol Chem 281 (42), 31843-31853 (2006)
   PUBMED   16928684
REFERENCE   9  (bases 1 to 552)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (bases 1 to 552)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF386786.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF386786.1, DV216028.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..552
                     /gene="Rap2b"
                     /note="RAP2B, member of RAS oncogene family"
                     /db_xref="GeneID:170923"
                     /db_xref="RGD:620591"
     CDS             1..552
                     /gene="Rap2b"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rap-2b"
                     /protein_id="NP_596901.1"
                     /db_xref="GeneID:170923"
                     /db_xref="RGD:620591"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEI
                     VRQMNYAAQPNGDEGCCSACVIL"
     mat_peptide     1..540
                     /gene="Rap2b"
                     /product="Ras-related protein Rap-2b. /id=PRO_0000030219"
                     /note="propagated from UniProtKB/Swiss-Prot (P61227.1)"
     misc_feature    7..495
                     /gene="Rap2b"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; Region: Rap2; cd04176"
                     /db_xref="CDD:133376"
     misc_feature    7..495
                     /gene="Rap2b"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; Region: Rap2; cd04176"
                     /db_xref="CDD:133376"
     misc_feature    28..51
                     /gene="Rap2b"
                     /note="G1 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    28..51
                     /gene="Rap2b"
                     /note="G1 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(31..36,175..180)
                     /gene="Rap2b"
                     /note="putative GDI interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(31..36,175..180)
                     /gene="Rap2b"
                     /note="putative GDI interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(37..54,82..93,346..351,355..357,436..441)
                     /gene="Rap2b"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133376"
     misc_feature    order(37..54,82..93,346..351,355..357,436..441)
                     /gene="Rap2b"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133376"
     misc_feature    order(49..54,94..96,100..102,118..123,160..165,169..171,
                     175..180,442..444)
                     /gene="Rap2b"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(49..54,94..96,100..102,118..123,160..165,169..171,
                     175..180,442..444)
                     /gene="Rap2b"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(73..75,91..93,97..99,106..123)
                     /gene="Rap2b"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     misc_feature    order(73..75,91..93,97..99,106..123)
                     /gene="Rap2b"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     misc_feature    94..120
                     /gene="Rap2b"
                     /note="propagated from UniProtKB/Swiss-Prot (P61227.1);
                     Region: Effector region. /evidence=ECO:0000305"
     misc_feature    97..120
                     /gene="Rap2b"
                     /note="Switch I region; other site"
                     /db_xref="CDD:133376"
     misc_feature    97..120
                     /gene="Rap2b"
                     /note="Switch I region; other site"
                     /db_xref="CDD:133376"
     misc_feature    103..105
                     /gene="Rap2b"
                     /note="G2 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    103..105
                     /gene="Rap2b"
                     /note="G2 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    169..180
                     /gene="Rap2b"
                     /note="G3 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    169..180
                     /gene="Rap2b"
                     /note="G3 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(175..195,202..219,226..231)
                     /gene="Rap2b"
                     /note="Switch II region; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(175..195,202..219,226..231)
                     /gene="Rap2b"
                     /note="Switch II region; other site"
                     /db_xref="CDD:133376"
     misc_feature    346..357
                     /gene="Rap2b"
                     /note="G4 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    346..357
                     /gene="Rap2b"
                     /note="G4 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    436..444
                     /gene="Rap2b"
                     /note="G5 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    436..444
                     /gene="Rap2b"
                     /note="G5 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    538..540
                     /gene="Rap2b"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P61226; propagated from
                     UniProtKB/Swiss-Prot (P61227.1); methylation site"
     exon            1..552
                     /gene="Rap2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagagagt acaaagtggt ggtactgggc tcgggtggcg tgggcaagtc cgcgctcacc
       61 gtgcagttcg taacaggttc cttcatcgag aagtacgacc caaccatcga agacttttac
      121 cgcaaggaga tcgaggtgga ttcgtcgccg tcggttctgg agatcctgga caccgcgggc
      181 acggagcagt tcgcttccat gcgggacctg tacatcaaga atggccaggg cttcatcctc
      241 gtctacagcc tggtcaacca gcagagcttc caggacatca agcccatgcg ggaccagatc
      301 atccgcgtga aacggtacga gcgcgtaccc atgatcctgg taggcaacaa ggtggacctg
      361 gagggcgaac gtgaggtctc ctatggcgag ggcaaggccc tggccgagga gtggagctgc
      421 cccttcatgg aaacatcggc caaaaacaaa gcctcagtgg atgagctatt cgcagagatc
      481 gtgaggcaga tgaactacgc ggcacagccc aacggcgacg agggctgctg ctcggcctgc
      541 gtgatcctgt ga
//
LOCUS       NM_175586               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 7b (Taar7b),
            mRNA.
ACCESSION   NM_175586
VERSION     NM_175586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Ferrero,D.M., Wacker,D., Roque,M.A., Baldwin,M.W., Stevens,R.C. and
            Liberles,S.D.
  TITLE     Agonists for 13 trace amine-associated receptors provide insight
            into the molecular basis of odor selectivity
  JOURNAL   ACS Chem Biol 7 (7), 1184-1189 (2012)
   PUBMED   22545963
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702319.1.
            
            On Nov 18, 2005 this sequence version replaced NM_175586.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="trace amine-associated receptor 7b"
                     /db_xref="GeneID:294126"
                     /db_xref="RGD:631392"
     CDS             1..1077
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="taR-12; taR-7b; trace amine receptor 7b; trace
                     amine receptor 12"
                     /codon_start=1
                     /product="trace amine-associated receptor 7b"
                     /protein_id="NP_783176.2"
                     /db_xref="GeneID:294126"
                     /db_xref="RGD:631392"
                     /translation="MATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSP
                     GPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMP
                     FSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFT
                     ASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINF
                     LLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLG
                     IAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFR
                     KAIKLIVTGKILRENSSATNLFPE"
     misc_feature    100..102
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923X8.2); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    148..222
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    247..315
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    247..315
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    250..312
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    361..429
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    376..441
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    496..546
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    499..561
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    628..699
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    628..630
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923X8.2); glycosylation site"
     misc_feature    634..696
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    814..882
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    823..885
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    913..990
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    928..996
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X8.2);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7b"
                     /gene_synonym="TA12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctacag atgatgaccg ctttccctgg gatcaggaca gcatcctgag cagagatctg
       61 ctctcagcct catctatgca gctgtgctat gagaaactga acagatcctg tgtcaggagc
      121 ccatactccc caggccctcg cctcatcctt tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tcttggtggg tctgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttggaga catttattgt
      361 aaattccatt cttcttttga tgggtcattc tgctattctt ctatattcca cttgtgtttc
      421 atctctgctg atagatacat tgcagtcagt gaccccctga tctaccccac caggttcact
      481 gcatctgttt ctggcaagtg tatcaccttc tcctggctcc tgtccatcat ctacagcttt
      541 tccctttttt acacaggggt caatgaagct gggctggagg atctagtgag tgccctcacc
      601 tgtgtgggtg gatgtcaaat cgcagtgaat caaagctggg tcttcatcaa tttcctattg
      661 tttcttgtcc ctgcgcttgt gatgatgact gtctactcta agatcttcct cattgcaaag
      721 cagcaggctc agaacattga gaagatgggc aagcagaccg ccagggcatc tgaaagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccctgggcat cgcagtggct
      841 gccttcctcc tttcatggct gccatacttc attgactcca tcattgacgc cttccttggg
      901 tttgtcacgc ccacgtatgt gtatgaaatc ctagtttgga taggttacta taactcagcc
      961 atgaaccctt tgatttatgc tttcttttat ccttggtttc gaaaagccat caaactcatt
     1021 gtcactggca aaatcttgag agagaattct tcagccacca acctgtttcc tgagtag
//
LOCUS       NM_001080939             963 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 109 (Tas2r109),
            mRNA.
ACCESSION   NM_001080939 XM_001074843
VERSION     NM_001080939.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY486338.1.
            
            On Jan 31, 2007 this sequence version replaced XM_001074843.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..963
                     /gene="Tas2r109"
                     /note="taste receptor, type 2, member 109"
                     /db_xref="GeneID:690572"
                     /db_xref="RGD:1594689"
     CDS             1..963
                     /gene="Tas2r109"
                     /note="putative taste receptor T2R38; T2R109; taste
                     receptor type 2 member 38"
                     /codon_start=1
                     /product="taste receptor type 2 member 109"
                     /protein_id="NP_001074408.1"
                     /db_xref="GeneID:690572"
                     /db_xref="RGD:1594689"
                     /translation="MEHFLKSIFDISKNVLPIILFIELIIGIIGNGFMALVHCMDWVK
                     RKKMSLVNQILTTLATSRICLLWFMLLGLLITLLDPDLASARMMIQVASNLWIIANHM
                     SIWLATCLTVFYFLKIANFSSSLFLYLKWRVEKVISVIFLVSLVLLFLNMLLMNLEND
                     MCIAEYHQINISYSFIYHYRADCERRVLRLHIIILSVPFVLSLPTFLLLIFSLWTHHK
                     KMQQHVQGRRDASTTAHFKALQTVIAFLLLYCIFILSMLLQFWKYELMKKPLFILFCH
                     IVYGAFPSFHSYVLILGDMKLRQASLSVLLWLKCRPNYIETLDL"
     misc_feature    43..915
                     /gene="Tas2r109"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    43..915
                     /gene="Tas2r109"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    43..120
                     /gene="Tas2r109"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    43..120
                     /gene="Tas2r109"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    43..105
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    154..228
                     /gene="Tas2r109"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    154..228
                     /gene="Tas2r109"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    187..249
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    268..336
                     /gene="Tas2r109"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    268..336
                     /gene="Tas2r109"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    283..345
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    406..468
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    415..465
                     /gene="Tas2r109"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    415..465
                     /gene="Tas2r109"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    508..510
                     /gene="Tas2r109"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q675B9.1); glycosylation site"
     misc_feature    550..621
                     /gene="Tas2r109"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    550..621
                     /gene="Tas2r109"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    574..636
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    694..771
                     /gene="Tas2r109"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    694..771
                     /gene="Tas2r109"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    721..783
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     misc_feature    805..882
                     /gene="Tas2r109"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    805..882
                     /gene="Tas2r109"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    811..873
                     /gene="Tas2r109"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B9.1);
                     transmembrane region"
     exon            1..963
                     /gene="Tas2r109"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagcatt ttttgaagag tatatttgat atctccaaga atgtacttcc aattatttta
       61 ttcattgaat taataattgg aattatagga aatggtttca tggccctggt gcattgcatg
      121 gactgggtta agagaaaaaa aatgtcatta gttaaccaaa tcctcaccac cttagcaacc
      181 tccagaattt gtctgctctg gttcatgcta ttaggtttac taattacctt actggatcca
      241 gatttagcta gtgctagaat gatgatccag gtcgccagta atctgtggat tatagctaac
      301 catatgagca tttggcttgc tacatgcctc actgtttttt attttctcaa gatagccaat
      361 ttttctagct ctctttttct ttatctaaag tggagagttg aaaaagtcat ttcagttata
      421 tttctggtgt cgctggtctt actgttttta aatatgttac taatgaactt ggaaaatgac
      481 atgtgtatag ctgaatatca tcagataaat atatcgtaca gcttcattta ccattaccgt
      541 gcagactgcg aaaggcgtgt tttaagactt cacattatca tcttgtctgt cccctttgtt
      601 ttgtccctgc caacttttct cctgctcatc ttctccctgt ggacacatca caagaagatg
      661 cagcagcatg ttcaaggacg ccgagatgcc agcaccacgg cccacttcaa agccttgcag
      721 accgtgatcg cctttctcct attatactgt atttttattc tgtctatgtt actacaattt
      781 tggaaatatg aattaatgaa gaaacccctt ttcattttat tttgtcatat tgtatatgga
      841 gctttccctt cattccattc atatgtcttg attctgggcg acatgaagct gagacaggcc
      901 tctctctctg tgctgttgtg gctgaaatgc aggccaaatt acatagaaac gttagatctc
      961 taa
//
LOCUS       NM_001037852             402 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus sperm associated antigen 11b (Spag11b),
            transcript variant 1, mRNA.
ACCESSION   NM_001037852
VERSION     NM_001037852.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Ribeiro,C.M., Queiroz,D.B., Patrao,M.T., Denadai-Souza,A.,
            Romano,R.M., Silva,E.J. and Avellar,M.C.
  TITLE     Dynamic changes in the spatio-temporal expression of the
            beta-defensin SPAG11C in the developing rat epididymis and its
            regulation by androgens
  JOURNAL   Mol Cell Endocrinol 404, 141-150 (2015)
   PUBMED   25657045
  REMARK    GeneRIF: Results from the spatio-temporal expression, cellular
            distribution showed that SPAG11C may play a role in epididymal
            development and/or sperm function.
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Yenugu,S., Hamil,K.G., French,F.S. and Hall,S.H.
  TITLE     Antimicrobial actions of human and macaque sperm associated antigen
            (SPAG) 11 isoforms: influence of the N-terminal peptide
  JOURNAL   Mol Cell Biochem 284 (1-2), 25-37 (2006)
   PUBMED   16411022
REFERENCE   3  (bases 1 to 402)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ012093.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012093.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..402
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="sperm associated antigen 11b"
                     /db_xref="GeneID:100362580"
                     /db_xref="RGD:1562239"
     CDS             1..402
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sperm associated antigen 11C-like; sperm
                     associated antigen 11b-like"
                     /codon_start=1
                     /product="sperm-associated antigen 11B isoform 1
                     precursor"
                     /protein_id="NP_001032941.1"
                     /db_xref="GeneID:100362580"
                     /db_xref="RGD:1562239"
                     /translation="MKRRLLPSFVSLLLAALLLPGKAETWLRSWTQALSAGVTLGSSS
                     ASSINHLVTEPPSSPQDEFPAQGGNGSGLLHHRVKRFPPRTPPYHEPGPNYQIVNCKK
                     NEGFCQKYCNFMETQVGYCSKKKEACCLHPF"
     sig_peptide     1..69
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <121..276
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="Sperm antigen HE2; Region: Sperm_Ag_HE2; pfam05324"
                     /db_xref="CDD:461622"
     misc_feature    <121..276
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="Sperm antigen HE2; Region: Sperm_Ag_HE2; pfam05324"
                     /db_xref="CDD:461622"
     exon            1..121
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
     exon            122..268
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
     exon            269..402
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaacgga gactccttcc ttcctttgtc agcctcctcc ttgcagccct gctccttcca
       61 ggtaaagcag aaacatggct tcgttcctgg acccaggctc tttcagcagg tgtcacttta
      121 gggtcgtcca gtgcctcgtc cattaaccac ttagtcactg aaccccccag ttccccccag
      181 gacgaatttc ctgcccaagg aggaaatggg tctgggttgt tgcatcacag agtgaaacgc
      241 ttccctccac gcaccccccc ttaccatgag cctggaccaa attaccaaat tgtcaactgc
      301 aagaaaaatg agggattctg tcaaaaatac tgtaatttta tggaaacaca agtgggctac
      361 tgttcaaaaa agaaagaagc ctgctgctta catcccttct ga
//
LOCUS       NM_001260484             306 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed 14 like 2
            (Pate14l2), mRNA.
ACCESSION   NM_001260484 XM_002727017 XM_002729888
VERSION     NM_001260484.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 306)
  AUTHORS   Rajesh,A. and Yenugu,S.
  TITLE     Genomic organization, tissue distribution and functional
            characterization of the rat Pate gene cluster
  JOURNAL   PLoS One 7 (3), e32633 (2012)
   PUBMED   22479333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JQ031758.1.
            
            On or before May 7, 2012 this sequence version replaced
            XM_002727017.1, XM_002729888.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ031758.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..306
                     /gene="Pate14l2"
                     /note="prostate and testis expressed 14 like 2"
                     /db_xref="GeneID:100360049"
                     /db_xref="RGD:2322896"
     CDS             1..306
                     /gene="Pate14l2"
                     /note="prostate and testis expressed protein P; Secreted
                     seminal-vesicle Ly-6 protein 1-like; rCG64165-like"
                     /codon_start=1
                     /product="prostate and testis expressed 14 like 2
                     precursor"
                     /protein_id="NP_001247413.1"
                     /db_xref="GeneID:100360049"
                     /db_xref="RGD:2322896"
                     /translation="MGKDILLLLLGLSLLVSSMQALTCIKCERFNSQGICERGEGCCE
                     AQPGEKCASLITYKDGKIQFGSQRCADLCYRGTVENGGLTIKMNCCSHRSFCNKPYP"
     sig_peptide     1..63
                     /gene="Pate14l2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    58..294
                     /gene="Pate14l2"
                     /note="extracellular domain (ECD) found in acrosomal
                     protein SP-10, prostate and testis expressed protein 14
                     (Pate14) and similar proteins; Region:
                     TFP_LU_ECD_SP10_like; cd23628"
                     /db_xref="CDD:467148"
     misc_feature    58..294
                     /gene="Pate14l2"
                     /note="extracellular domain (ECD) found in acrosomal
                     protein SP-10, prostate and testis expressed protein 14
                     (Pate14) and similar proteins; Region:
                     TFP_LU_ECD_SP10_like; cd23628"
                     /db_xref="CDD:467148"
     exon            1..61
                     /gene="Pate14l2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..175
                     /gene="Pate14l2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..306
                     /gene="Pate14l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaaagg acatcttgct gctcctgctg ggcctgtctt tgctagtgag ctccatgcaa
       61 gctttgacat gtatcaagtg tgaaaggttc aattctcagg ggatttgtga gagaggagaa
      121 ggttgctgtg aggctcaacc tggtgagaaa tgtgcctcac ttataaccta taaagatggc
      181 aaaattcagt ttggaagcca gagatgtgct gatctttgct acagagggac tgttgagaat
      241 ggaggtctga caataaaaat gaactgttgc tcacacaggt ctttctgcaa taaaccatat
      301 ccgtga
//
LOCUS       NM_001109347             930 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus olfactory receptor family 2 subfamily A member 52
            (Or2a52), mRNA.
ACCESSION   NM_001109347 XM_001072921 XM_578256
VERSION     NM_001109347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001072921.1, XM_578256.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..930
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="olfactory receptor family 2 subfamily A member 52"
                     /db_xref="GeneID:502758"
                     /db_xref="RGD:1587195"
     CDS             1..930
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="olfactory receptor 437"
                     /codon_start=1
                     /product="olfactory receptor family 2 subfamily A member
                     52"
                     /protein_id="NP_001102817.1"
                     /db_xref="GeneID:502758"
                     /db_xref="RGD:1587195"
                     /translation="MGANQTWVTEFILVGLQLSAGMEMFLFWIFSLLYILSLLANGII
                     LALICLDPRLHTPMYFFLSHLAILDMSYASNNVPKMLSNLVNQKKTISFVPCVTQTFL
                     YLAFAASECLILAAMSYDRFVAICHPLHYTVIMSWKVCVALAVTSWSCGFILSVAHTI
                     LLLKLPFCGPQEVNHLFCEILAVLKLACADTLINQIVILAACVFVLVGPLCSMLVSYT
                     HILWTILKMQSKEGRKKAFSTCSSHLCVVGLFFGIAMLVYMVPDSDQREEQEKILSLF
                     HSLFNPMLNPLIYSLRNAQVKEAFHRALQKRSV"
     misc_feature    70..900
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="olfactory receptor subfamily 2A and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR2A-like; cd15420"
                     /db_xref="CDD:320542"
     misc_feature    70..900
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="olfactory receptor subfamily 2A and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR2A-like; cd15420"
                     /db_xref="CDD:320542"
     misc_feature    73..153
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320542"
     misc_feature    73..153
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320542"
     misc_feature    172..252
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320542"
     misc_feature    172..252
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320542"
     misc_feature    order(238..240,247..252,286..303,307..312,319..321,
                     454..456,460..474,580..582,589..597,601..609,613..618,
                     751..753,760..765,769..774,781..783,799..804,808..816,
                     823..825,832..837)
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320542"
     misc_feature    order(238..240,247..252,286..303,307..312,319..321,
                     454..456,460..474,580..582,589..597,601..609,613..618,
                     751..753,760..765,769..774,781..783,799..804,808..816,
                     823..825,832..837)
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320542"
     misc_feature    286..378
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320542"
     misc_feature    286..378
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320542"
     misc_feature    415..480
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320542"
     misc_feature    415..480
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320542"
     misc_feature    580..672
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320542"
     misc_feature    580..672
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320542"
     misc_feature    691..783
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320542"
     misc_feature    691..783
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320542"
     misc_feature    802..879
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320542"
     misc_feature    802..879
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320542"
     exon            1..930
                     /gene="Or2a52"
                     /gene_synonym="Olr437"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggagcca accagacatg ggtcacagaa ttcatcctcg tgggactcca gctcagcgca
       61 ggcatggaaa tgttcctctt ctggattttc tccctgctgt acatcctcag cctcctggca
      121 aatggcataa tcttagcact catctgcctg gaccccaggc tgcacacccc gatgtacttc
      181 tttctttctc atctggccat tcttgacatg tcctatgctt ccaacaatgt ccccaagatg
      241 ttgtccaacc ttgtaaacca gaaaaagacc atctcatttg tcccatgcgt cacacagaca
      301 ttcttgtatt tggcttttgc tgcttcagag tgcttgattt tggcagccat gtcctatgac
      361 cggtttgtgg ccatctgcca cccccttcac tatactgtca tcatgagttg gaaagtatgt
      421 gtggccctgg ctgtcacatc ctggtcatgt ggatttatcc tctctgtggc tcacacaatt
      481 ctcctgctaa agctgccctt ctgtgggccc caggaggtaa accacctctt ctgtgaaatc
      541 ctggctgttc tcaagctggc ctgtgctgac actttgatca accaaatcgt catccttgct
      601 gcatgtgttt ttgttttagt tgggcccctt tgttcaatgc ttgtatctta cacacatatc
      661 ctctggacaa ttctgaaaat gcagtcaaag gagggacgca agaaggcctt ttccacctgc
      721 tcctctcatc tctgtgtggt ggggctcttc tttggaatag ccatgttggt gtatatggtc
      781 cctgattctg atcagcgaga ggagcaggag aaaattttgt ccctgttcca cagtctcttt
      841 aacccaatgc tgaaccccct catctatagt ctgaggaacg cccaggtgaa ggaagccttc
      901 cacagagcac tgcagaagag atctgtgtga
//
LOCUS       NM_001031824            1266 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus bone morphogenetic protein 10 (Bmp10), mRNA.
ACCESSION   NM_001031824 XM_575595
VERSION     NM_001031824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Hirono,K., Saito,K., Munkhsaikhan,U., Xu,F., Wang,C., Lu,L.,
            Ichida,F., Towbin,J.A. and Purevjav,E.
  TITLE     Familial Left Ventricular Non-Compaction Is Associated With a Rare
            p.V407I Variant in Bone Morphogenetic Protein 10
  JOURNAL   Circ J 83 (8), 1737-1746 (2019)
   PUBMED   31243186
  REMARK    GeneRIF: W143*-NRG1and V470I-BMP10 variants are associated with
            left ventricular non-compaction.
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Sun,L., Yu,J., Qi,S., Hao,Y., Liu,Y. and Li,Z.
  TITLE     Bone morphogenetic protein-10 induces cardiomyocyte proliferation
            and improves cardiac function after myocardial infarction
  JOURNAL   J Cell Biochem 115 (11), 1868-1876 (2014)
   PUBMED   24906204
  REMARK    GeneRIF: These data indicated that BMP10 stimulated cardiomyocyte
            proliferation and repaired cardiac function after heart injury.
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Yan,Y., Gong,P., Jin,W., Xu,J., Wu,X., Xu,T., Hang,Q., Fu,H.,
            Kei,K. and Gao,Y.
  TITLE     The cell-specific upregulation of bone morphogenetic protein-10
            (BMP-10) in a model of rat cortical brain injury
  JOURNAL   J Mol Histol 43 (5), 543-552 (2012)
   PUBMED   22797972
  REMARK    GeneRIF: the present data suggested that BMP-10 may be implicated
            in CNS pathophysiology after traumatic brain injury
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Somekawa,S., Imagawa,K., Hayashi,H., Sakabe,M., Ioka,T., Sato,G.E.,
            Inada,K., Iwamoto,T., Mori,T., Uemura,S., Nakagawa,O. and Saito,Y.
  TITLE     Tmem100, an ALK1 receptor signaling-dependent gene essential for
            arterial endothelium differentiation and vascular morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12064-12069 (2012)
   PUBMED   22783020
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Seemann,P., Brehm,A., Konig,J., Reissner,C., Stricker,S., Kuss,P.,
            Haupt,J., Renninger,S., Nickel,J., Sebald,W., Groppe,J.C.,
            Ploger,F., Pohl,J., Schmidt-von Kegler,M., Walther,M., Gassner,I.,
            Rusu,C., Janecke,A.R., Dathe,K. and Mundlos,S.
  TITLE     Mutations in GDF5 reveal a key residue mediating BMP inhibition by
            NOGGIN
  JOURNAL   PLoS Genet 5 (11), e1000747 (2009)
   PUBMED   19956691
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Chen,H., Yong,W., Ren,S., Shen,W., He,Y., Cox,K.A., Zhu,W., Li,W.,
            Soonpaa,M., Payne,R.M., Franco,D., Field,L.J., Rosen,V., Wang,Y.
            and Shou,W.
  TITLE     Overexpression of bone morphogenetic protein 10 in myocardium
            disrupts cardiac postnatal hypertrophic growth
  JOURNAL   J Biol Chem 281 (37), 27481-27491 (2006)
   PUBMED   16798733
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Mazerbourg,S., Sangkuhl,K., Luo,C.W., Sudo,S., Klein,C. and
            Hsueh,A.J.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Tsuji,A.B., Sugyo,A., Ogiu,T., Sagara,M., Kimura,T., Ishikawa,A.,
            Sudo,H., Ohtsuki,M., Aburatani,H., Imai,T. and Harada,Y.N.
  TITLE     Fine mapping of radiation susceptibility and gene expression
            analysis of LEC congenic rat lines
  JOURNAL   Genomics 86 (3), 271-279 (2005)
   PUBMED   15978772
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Chen,H., Shi,S., Acosta,L., Li,W., Lu,J., Bao,S., Chen,Z., Yang,Z.,
            Schneider,M.D., Chien,K.R., Conway,S.J., Yoder,M.C., Haneline,L.S.,
            Franco,D. and Shou,W.
  TITLE     BMP10 is essential for maintaining cardiac growth during murine
            cardiogenesis
  JOURNAL   Development 131 (9), 2219-2231 (2004)
   PUBMED   15073151
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Neuhaus,H., Rosen,V. and Thies,R.S.
  TITLE     Heart specific expression of mouse BMP-10 a novel member of the
            TGF-beta superfamily
  JOURNAL   Mech Dev 80 (2), 181-184 (1999)
   PUBMED   10072785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB158417.1.
            
            On Aug 19, 2005 this sequence version replaced XM_575595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB158417.1, AB158418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/DuCrj"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1266
                     /gene="Bmp10"
                     /note="bone morphogenetic protein 10"
                     /db_xref="GeneID:500245"
                     /db_xref="RGD:1562986"
     CDS             1..1266
                     /gene="Bmp10"
                     /note="BMP-10"
                     /codon_start=1
                     /product="bone morphogenetic protein 10 precursor"
                     /protein_id="NP_001026994.1"
                     /db_xref="GeneID:500245"
                     /db_xref="RGD:1562986"
                     /translation="MGSLVLPLSAVFCLVARLASGSPIMGLEQSPLEEDMPFFDDIFT
                     EQDGIDFNTLLQSMKDEFLKTLNLSDIPPQDTGRVDPPEYMLELYNKFATDRTSMPSA
                     NIIRSFKNEDLFSQPVSFNGIRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRLMYDG
                     VDRKIIIFEVLESADGSEDERSMLVLVSTEIYGTNSEWETFDITDATRRWQKSGPSTH
                     QLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSGDKEQKEELNELISH
                     EQDLDLGTDGFFGGPDEEALLQMRSNMIDDSTARIRRNAKGNYCKKTPLYIDFKEIGW
                     DSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLD
                     PISILYLDKGVVTYKFKYEGMAVSECGCR"
     sig_peptide     1..63
                     /gene="Bmp10"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    163..768
                     /gene="Bmp10"
                     /note="TGF-beta propeptide; Region: TGFb_propeptide;
                     cl46657"
                     /db_xref="CDD:480997"
     misc_feature    163..768
                     /gene="Bmp10"
                     /note="TGF-beta propeptide; Region: TGFb_propeptide;
                     cl46657"
                     /db_xref="CDD:480997"
     misc_feature    199..201
                     /gene="Bmp10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4AEG6.1); glycosylation site"
     misc_feature    391..393
                     /gene="Bmp10"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4AEG6.1); glycosylation site"
     mat_peptide     940..1263
                     /gene="Bmp10"
                     /product="Bone morphogenetic protein 10.
                     /evidence=ECO:0000255. /id=PRO_0000310576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4AEG6.1)"
     misc_feature    952..1263
                     /gene="Bmp10"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in bone morphogenetic protein 10 (BMP-10) and
                     similar proteins; Region: TGF_beta_BMP10; cd19401"
                     /db_xref="CDD:381671"
     misc_feature    952..1263
                     /gene="Bmp10"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in bone morphogenetic protein 10 (BMP-10) and
                     similar proteins; Region: TGF_beta_BMP10; cd19401"
                     /db_xref="CDD:381671"
     misc_feature    order(973..975,979..981,991..996,1000..1002,1030..1032,
                     1036..1044,1093..1098,1105..1110,1114..1119,1126..1128,
                     1138..1146,1153..1155,1159..1164,1171..1173,1231..1239,
                     1243..1245,1261..1263)
                     /gene="Bmp10"
                     /note="putative homodimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381671"
     misc_feature    order(973..975,979..981,991..996,1000..1002,1030..1032,
                     1036..1044,1093..1098,1105..1110,1114..1119,1126..1128,
                     1138..1146,1153..1155,1159..1164,1171..1173,1231..1239,
                     1243..1245,1261..1263)
                     /gene="Bmp10"
                     /note="putative homodimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381671"
     exon            1..334
                     /gene="Bmp10"
                     /inference="alignment:Splign:2.1.0"
     exon            335..1266
                     /gene="Bmp10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggttctc tggttctgcc gctgagcgcc gtcttctgcc tggtggctcg tctggcttct
       61 ggcagcccca tcatgggcct tgagcagtcg cccctggaag aagacatgcc cttctttgat
      121 gatatcttca cagaacaaga tggtattgac ttcaacacac tgctgcagag catgaaggac
      181 gagtttctca agacgttgaa tctgtcagac attcccccac aggacacagg cagagtggat
      241 ccgccggagt acatgctgga gctctacaac aaattcgcca cggaccggac ctccatgcca
      301 tctgctaaca tcatccggag cttcaagaat gaagatctgt tttctcaacc agtcagtttc
      361 aatgggatcc ggaagtatcc tctcctcttc aacgtgtcca tccctcacca cgaagaggtc
      421 gtcatggctg aactgaggtt gtacacgctg gtgcagagag atcgtttgat gtatgatggt
      481 gtggaccgta aaataatcat ctttgaggtt ctagagagtg ccgatggtag cgaggatgag
      541 aggagcatgc tggtcttggt atcaacggag atctacggaa ccaacagtga gtgggagaca
      601 tttgacatca cggatgccac cagacgttgg caaaagtcag gcccatcaac ccaccagctg
      661 gagatccaca tcgaaagcag acaaaaccaa gctgaggaca ccggaagggg acaactggaa
      721 atagatatga gtgctcagaa taagcacgac cctttgcttg ttgtgttttc tgatgaccaa
      781 agcggtgaca aggagcagaa agaagagctg aatgaactga tctcccacga gcaggatctg
      841 gacctgggca ccgatggttt ctttggtggg cctgatgaag aggctctcct gcagatgagg
      901 tcaaacatga tcgatgactc taccgctcgg atcaggagga acgccaaggg gaactactgc
      961 aagaagactc cactgtacat cgacttcaag gagatcggct gggactcctg gatcatcgcg
     1021 cctcctggtt acgaggccta tgagtgccgc ggtgtgtgca actaccctct ggcggagcac
     1081 ctcacaccta cgaaacacgc aattatccag gccttggtcc acctcaagaa ttcccagaaa
     1141 gcctccaaag cctgctgcgt gcccacgaag ctggatccca tctccatcct ctatttagat
     1201 aaaggtgttg tcacctataa gtttaaatac gaaggaatgg ccgtgtctga atgtggctgt
     1261 agatag
//
LOCUS       NM_001109427            1269 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ankyrin repeat domain 65 (Ankrd65), mRNA.
ACCESSION   NM_001109427 XM_001058618
VERSION     NM_001109427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Boiko,T., Vakulenko,M., Ewers,H., Yap,C.C., Norden,C. and
            Winckler,B.
  TITLE     Ankyrin-dependent and -independent mechanisms orchestrate axonal
            compartmentalization of L1 family members neurofascin and
            L1/neuron-glia cell adhesion molecule
  JOURNAL   J Neurosci 27 (3), 590-603 (2007)
   PUBMED   17234591
  REMARK    GeneRIF: Ankyrin B is expressed along the entire lengths of axons.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001058618.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132292, SAMD00132297
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1269
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ankyrin repeat domain 65"
                     /db_xref="GeneID:680734"
                     /db_xref="RGD:1588232"
     exon            1..356
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="upstream in-frame stop codon"
     CDS             172..1269
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 65"
                     /protein_id="NP_001102897.1"
                     /db_xref="GeneID:680734"
                     /db_xref="RGD:1588232"
                     /translation="MDSSRLKQELQWMKLVWEETPADKTDRPLTPQGWSTLFQAVWWG
                     APSLVMQLLRQGASVEERDHTGRTPLHLAVMRGHAPLVRLLLQRGALAGAVDHTGRTP
                     LHEAAWHGHSNVAELLLRRGASAAAPCSQTGLTPLHGAAALGRTLLVTCFTAAPDSVP
                     DVKDIRGWTATHWAAACGQLPVLELLTAGGSVDLDGALLVSAVAGSASALRLLLTLGA
                     KVDALDSTGATALGLAAGLGHHQEIEVLLGHGADPNIRDRNNRSALHRAASGGCLRAI
                     QLLVAKGTDVDARDSLGLTPLHYAARGGHREVVSHLLDRGAHVDAAGWLHKTPLHLAV
                     ECGHTTILELLLSRGANPSLRTQWGEVAQIP"
     misc_feature    268..360
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    268..360
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(271..273,283..288,295..303,307..312,322..324,
                     331..333,358..360,364..366,370..372,382..387,394..402,
                     406..411,421..423,430..432,457..459,463..465,469..471,
                     481..486,493..501,505..510,520..522,529..531)
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(271..273,283..288,295..303,307..312,322..324,
                     331..333,358..360,364..366,370..372,382..387,394..402,
                     406..411,421..423,430..432,457..459,463..465,469..471,
                     481..486,493..501,505..510,520..522,529..531)
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    280..543
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:463710"
     misc_feature    280..543
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:463710"
     misc_feature    364..459
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    364..459
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    463..540
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    463..540
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    511..1263
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    511..1263
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    760..843
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    760..843
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    850..942
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    850..942
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(946..948,952..954,964..969,976..984,988..993,
                     1003..1005,1012..1014,1039..1041,1045..1047,1051..1053,
                     1063..1068,1075..1083,1087..1092,1102..1104,1111..1113,
                     1138..1140,1144..1146,1150..1152,1162..1167,1174..1182,
                     1186..1191,1201..1203,1210..1212)
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(946..948,952..954,964..969,976..984,988..993,
                     1003..1005,1012..1014,1039..1041,1045..1047,1051..1053,
                     1063..1068,1075..1083,1087..1092,1102..1104,1111..1113,
                     1138..1140,1144..1146,1150..1152,1162..1167,1174..1182,
                     1186..1191,1201..1203,1210..1212)
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    946..1041
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    946..1041
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1045..1140
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1045..1140
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1144..1236
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1144..1236
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            357..894
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1269
                     /gene="Ankrd65"
                     /gene_synonym="RGD1562345"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtcagag ctcctgtgcc agctccctct gtaggtaatt gggagccaca gcccttcaga
       61 aggctaaagg gtgtgagtcc ttctggtgga gtggtgacat ggtgacaagg gacaggtaag
      121 gtgaaccagc caggggcctt agtgtggacg caggtccctg ctctccccta gatggattcc
      181 agcaggctga agcaagaact acagtggatg aagctggtct gggaggagac cccagcagac
      241 aagacagaca gacctcttac acctcagggc tggagtactt tgttccaggc agtgtggtgg
      301 ggagctccca gcctggtgat gcagctgctg aggcaaggtg ccagtgtgga ggagagggat
      361 cacacaggta ggactccgct ccatctggct gtgatgcgag ggcacgcacc attggttcgc
      421 ctactgttgc agcggggggc cctggcaggt gcagttgacc acacagggcg cacaccactg
      481 cacgaggctg cctggcatgg gcactcgaac gtggcagaac tattgctgcg acgcggggct
      541 tcagcagctg ctccatgctc tcaaacgggc ctcacgcccc tgcacggggc agctgctctg
      601 ggccgcacgc tactggttac atgctttacg gcggctccag attcagtccc tgatgtgaaa
      661 gacataagag gctggactgc cacacactgg gcagcagctt gtgggcaact gccggtgctg
      721 gagctactga ctgctggagg cagtgtagac ctggacggcg ctctgctggt gtcagcggta
      781 gctggaagtg cgtcagcgtt gcggcttctc ctgacactgg gggcaaaggt ggacgccctg
      841 gacagtacag gagccaccgc acttggcctg gcagctggct taggccacca ccaagaaatt
      901 gaggtgctgc tgggccatgg ggcagaccca aatatcaggg acaggaacaa ccgctctgca
      961 ctccacaggg ctgccagtgg tggctgtcta cgtgctatac agctgctggt ggctaagggc
     1021 accgacgtag atgctcgaga ctctctgggc ctcacacctc tgcactatgc tgctcgggga
     1081 ggccacagag aagttgtcag ccatctcctg gacaggggtg cgcacgtcga tgctgctggt
     1141 tggctccaca agacccctct gcatcttgct gtagaatgtg gccataccac cattctggag
     1201 cttttgctga gccgaggagc caacccttcc ttgaggacac aatggggtga agtagcccag
     1261 atcccatag
//
LOCUS       NM_175599               1125 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine associated receptor 8A (Taar8a),
            mRNA.
ACCESSION   NM_175599
VERSION     NM_175599.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Chiellini,G., Erba,P., Carnicelli,V., Manfredi,C., Frascarelli,S.,
            Ghelardoni,S., Mariani,G. and Zucchi,R.
  TITLE     Distribution of exogenous [125I]-3-iodothyronamine in mouse in
            vivo: relationship with trace amine-associated receptors
  JOURNAL   J Endocrinol 213 (3), 223-230 (2012)
   PUBMED   22442117
  REMARK    GeneRIF: Data show that TAARs were expressed only at trace amounts
            in most of the tissues, the exceptions being TAAR1 in stomach and
            testis and TAAR8a in intestine, spleen, and testis.
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380199.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1125
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="trace amine associated receptor 8A"
                     /db_xref="GeneID:319104"
                     /db_xref="RGD:631391"
     CDS             1..1125
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="taR-11; taR-8a; trace amine receptor 8a; trace
                     amine receptor 11; trace amine receptor 5"
                     /codon_start=1
                     /product="trace amine-associated receptor 8a"
                     /protein_id="NP_783189.1"
                     /db_xref="GeneID:319104"
                     /db_xref="RGD:631391"
                     /translation="MECISFIFVSHNCRCLLAGQKSLKHQKGRIMTSNFSQAPLQLCY
                     ENVNASCIKTPYSPGLRVLLYMVFGFGAVLAVCGNLLVVISVLHFKQLHSPANFLIAS
                     LASADFLVGISVMPFSMVRSIESCWYFGDTFCSLHSCCDAAFCYSSLFHLCFISVDRY
                     IAVTDPLVYPTKFTVSVSGICISISWILPLVYSSAVFYTGISATGIENLVSALNCVGG
                     CQIVVNQDWVLIDFLLFLIPTLVMIILYSKIFLVAKQQAVKIETSISGSKGESSLESH
                     KARVAKRERKAAKTLGVTVVAFMVSWLPYTIDTLIDAFMGFITPAYVYEICCWSAYYN
                     SAMNPLIYAFFYPWFRKAIKLILSGEILKSHSSTMSLFSE"
     misc_feature    184..1059
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    184..1059
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    190..264
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    190..264
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    289..357
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    289..357
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    403..471
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    403..471
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    538..588
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    538..588
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    670..741
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    670..741
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    862..930
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    862..930
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    961..1038
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    961..1038
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..1125
                     /gene="Taar8a"
                     /gene_synonym="Ta11; Trar5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtgca tttctttcat ttttgtgtct cacaattgcc gttgtcttct agcaggacag
       61 aaatccctca agcatcaaaa aggcagaatc atgacaagca acttttccca agcccccctg
      121 cagctctgct atgagaacgt gaatgcttcc tgcattaaaa ccccctattc gccagggctc
      181 cgggtcctcc tgtacatggt ctttggcttt ggggctgtgc tggcagtgtg tgggaacctc
      241 ctggtggtga tttcagtcct ccatttcaag cagctgcact ctcctgccaa tttcctcatc
      301 gcctccctgg ccagtgctga cttcttggtg ggcatctctg tgatgccctt cagcatggtc
      361 aggtccatcg agagctgctg gtactttgga gacacatttt gtagccttca cagctgctgt
      421 gatgcagcat tttgctattc ttctcttttc cacctctgtt tcatctctgt ggacaggtac
      481 atcgctgtca cggaccctct ggtctatccc accaagttca cagtgtctgt gtctggaatt
      541 tgcatcagca tctcctggat tctgcccctc gtgtacagca gtgcagtgtt ctacacaggc
      601 atcagtgcta cggggattga aaacttagta agtgctctca actgtgtagg gggctgccaa
      661 atcgttgtca atcaagactg ggttttgata gattttctct tattcctcat ccctaccctc
      721 gttatgatca tactctacag caaaatattt ttagtagcca aacagcaagc tgtaaaaatt
      781 gaaacttcta taagtggaag caaaggagaa tcgtccttag agagtcacaa agccagggtg
      841 gccaagagag agaggaaggc tgccaaaacc ttgggggtca ctgtggtggc atttatggtc
      901 tcatggctac catatacaat tgacaccttg attgatgctt tcatgggctt catcactcct
      961 gcctatgtct atgaaatttg ttgctggagc gcctattata actcagccat gaaccctttg
     1021 atttatgctt tcttttaccc ttggtttagg aaagccataa agctcatttt aagtggagag
     1081 attctaaaga gtcattcatc taccatgagt ttgttttcag agtaa
//
LOCUS       NM_001011701             585 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Spetex-2D protein (Spetex2d), mRNA.
ACCESSION   NM_001011701 XM_344303
VERSION     NM_001011701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Iwamoto,Y., Kaneko,T., Ichinose,J., Mori,T., Shibata,Y.,
            Toshimori,K. and Iida,H.
  TITLE     Molecular cloning of rat Spetex2 family genes mapped on chromosome
            15p16, encoding a 23-kilodalton protein associated with the plasma
            membranes of haploid spermatids
  JOURNAL   Biol Reprod 72 (2), 284-292 (2005)
   PUBMED   15371276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB180079.1.
            
            On Feb 9, 2005 this sequence version replaced XM_344303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180079.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..585
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /note="Spetex-2D protein"
                     /db_xref="GeneID:364260"
                     /db_xref="RGD:1359263"
     CDS             1..585
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /codon_start=1
                     /product="Spetex-2D protein"
                     /protein_id="NP_001011701.1"
                     /db_xref="GeneID:364260"
                     /db_xref="RGD:1359263"
                     /translation="MFHQLLKLVQKERGDQGETRPRQKKAGLLSWFIRKASSENFISN
                     HEKRIKKLEEVKSEIQKCKIERDELSQILDLYVNDGLNYRLSVELPMLKSQHEMRMMD
                     MHKMTNWISDAMEKYKELMQENNSYRIRNFHLLNERNELKKNVRILMNENRKLLVEQT
                     ELQASCEEGKRFCEEASKTIYTADIESLCPVTFE"
     misc_feature    100..342
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    100..342
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            1..91
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            92..251
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            252..383
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /inference="alignment:Splign:2.1.0"
     exon            384..585
                     /gene="Spetex2d"
                     /gene_synonym="Spetex-2D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttcacc agctgctcaa gctcgttcag aaggagaggg gagaccaagg agagaccaga
       61 ccgaggcaga agaaagctgg cctcctgtct tggtttattc ggaaggcatc atcagaaaat
      121 ttcatcagta accatgaaaa acgtataaag aaattggagg aagtaaaatc tgaaatccag
      181 aagtgtaaaa tcgagcggga tgaactttct caaatcctgg acctttatgt caatgatggt
      241 ttgaactaca ggctgagtgt tgaattgcca atgcttaaat cccaacatga gatgagaatg
      301 atggatatgc ataagatgac caactggata agtgatgcca tggagaagta caaggagctc
      361 atgcaagaga acaattccta ccgcatcaga aacttccacc tcctgaatga acgcaatgaa
      421 ttgaagaaga atgtaaggat tttgatgaat gagaacagaa aactgctggt ggagcagact
      481 gaactgcaag catcctgtga ggagggaaag aggttctgtg aggaggccag caagaccatc
      541 tacactgcag atattgaatc cttgtgtcct gttacttttg agtaa
//
LOCUS       NM_153304                905 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus free fatty acid receptor 1 (Ffar1), mRNA.
ACCESSION   NM_153304
VERSION     NM_153304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Li,S.N., Yu,Y.L., Wang,B.Y., Qiao,S.Y., Hu,M.M., Wang,H., Fu,C.N.
            and Dong,B.
  TITLE     Overexpression of G Protein-Coupled Receptor 40 Protects
            Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway
  JOURNAL   Hum Gene Ther 33 (11-12), 598-613 (2022)
   PUBMED   35018806
  REMARK    GeneRIF: Overexpression of G Protein-Coupled Receptor 40 Protects
            Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Xiao,J., Cai,T., Fang,Y., Liu,R., Flores,J.J., Wang,W., Gao,L.,
            Liu,Y., Lu,Q., Tang,L., Zhang,J.H., Lu,H. and Tang,J.
  TITLE     Activation of GPR40 attenuates neuroinflammation and improves
            neurological function via PAK4/CREB/KDM6B pathway in an
            experimental GMH rat model
  JOURNAL   J Neuroinflammation 18 (1), 160 (2021)
   PUBMED   34275493
  REMARK    GeneRIF: Activation of GPR40 attenuates neuroinflammation and
            improves neurological function via PAK4/CREB/KDM6B pathway in an
            experimental GMH rat model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Cho,Y.J., Choi,S.H., Lee,R., Hwang,H., Rhim,H., Cho,I.H., Kim,H.C.,
            Lee,J.I., Hwang,S.H. and Nah,S.Y.
  TITLE     Ginseng Gintonin Contains Ligands for GPR40 and GPR55
  JOURNAL   Molecules 25 (5), 1102 (2020)
   PUBMED   32121640
  REMARK    GeneRIF: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Kim,C.S., Joo,S.Y., Kim,I.J., Choi,H.I., Bae,E.H., Kim,S.W. and
            Ma,S.K.
  TITLE     Anti-Apoptotic Effect of G-Protein-Coupled Receptor 40 Activation
            on Tumor Necrosis Factor-alpha-Induced Injury of Rat Proximal
            Tubular Cells
  JOURNAL   Int J Mol Sci 20 (14), 3386 (2019)
   PUBMED   31295865
  REMARK    GeneRIF: our results demonstrate that GPR40 activation rescued cell
            death and activated the pro-apoptotic signaling pathway in
            TNF-alpha-induced injury of NRK52E cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Feng,X.T., Duan,H.M. and Li,S.L.
  TITLE     Protective role of Pollen Typhae total flavone against the palmitic
            acid-induced impairment of glucose-stimulated insulin secretion
            involving GPR40 signaling in INS-1 cells
  JOURNAL   Int J Mol Med 40 (3), 922-930 (2017)
   PUBMED   28731171
  REMARK    GeneRIF: The results indicate that Pollen Typhae total flavone
            exerts a protective role against PA-induced impairment of GSIS
            involving GPR40 signaling in INS-1 cells.
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Stoddart,L.A., Brown,A.J. and Milligan,G.
  TITLE     Uncovering the pharmacology of the G protein-coupled receptor
            GPR40: high apparent constitutive activity in guanosine
            5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of
            an endogenous agonist
  JOURNAL   Mol Pharmacol 71 (4), 994-1005 (2007)
   PUBMED   17200419
  REMARK    GeneRIF: GPR40 responded to fatty acids with different on-rates,
            and could be occupied by endogenous agonists before assay, masking
            the pharmacology of the receptor
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Fujiwara,K., Maekawa,F. and Yada,T.
  TITLE     Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat
            islet beta-cells: mediation by PLC and L-type Ca2+ channel and link
            to insulin release
  JOURNAL   Am J Physiol Endocrinol Metab 289 (4), E670-E677 (2005)
   PUBMED   15914509
  REMARK    GeneRIF: These results demonstrate that OA interacts with GPR40 to
            increase [Ca(2+)](i) via PLC- and L-type Ca(2+) channel-mediated
            pathway in rat islet beta-cells, which may be link to insulin
            release.
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Shapiro,H., Shachar,S., Sekler,I., Hershfinkel,M. and Walker,M.D.
  TITLE     Role of GPR40 in fatty acid action on the beta cell line INS-1E
  JOURNAL   Biochem Biophys Res Commun 335 (1), 97-104 (2005)
   PUBMED   16081037
  REMARK    GeneRIF: GPR40 promotes Ca2+ influx through up-regulation of L-type
            calcium channels pre-activated by glucose and membrane
            depolarization
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Briscoe,C.P., Tadayyon,M., Andrews,J.L., Benson,W.G.,
            Chambers,J.K., Eilert,M.M., Ellis,C., Elshourbagy,N.A., Goetz,A.S.,
            Minnick,D.T., Murdock,P.R., Sauls,H.R. Jr., Shabon,U.,
            Spinage,L.D., Strum,J.C., Szekeres,P.G., Tan,K.B., Way,J.M.,
            Ignar,D.M., Wilson,S. and Muir,A.I.
  TITLE     The orphan G protein-coupled receptor GPR40 is activated by medium
            and long chain fatty acids
  JOURNAL   J Biol Chem 278 (13), 11303-11311 (2003)
   PUBMED   12496284
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Itoh,Y., Kawamata,Y., Harada,M., Kobayashi,M., Fujii,R.,
            Fukusumi,S., Ogi,K., Hosoya,M., Tanaka,Y., Uejima,H., Tanaka,H.,
            Maruyama,M., Satoh,R., Okubo,S., Kizawa,H., Komatsu,H.,
            Matsumura,F., Noguchi,Y., Shinohara,T., Hinuma,S., Fujisawa,Y. and
            Fujino,M.
  TITLE     Free fatty acids regulate insulin secretion from pancreatic beta
            cells through GPR40
  JOURNAL   Nature 422 (6928), 173-176 (2003)
   PUBMED   12629551
  REMARK    GeneRIF: Free fatty acids regulate insulin secretion from
            pancreatic beta cells through GPR40
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF539810.1.
            
            On Aug 31, 2012 this sequence version replaced NM_153304.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF539810.1, AB095744.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-905               AF539810.1         3-907
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="free fatty acid receptor 1"
                     /db_xref="GeneID:266607"
                     /db_xref="RGD:628613"
     exon            1..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..905
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="G-protein coupled receptor 40"
                     /codon_start=1
                     /product="free fatty acid receptor 1"
                     /protein_id="NP_695216.1"
                     /db_xref="GeneID:266607"
                     /db_xref="RGD:628613"
                     /translation="MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVY
                     TLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSA
                     GRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGI
                     NIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKR
                     KLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVT
                     GYLGTGPGQGTICVTRTPRGTIQK"
     misc_feature    18..869
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    18..869
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    24..98
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    24..98
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    27..95
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    126..194
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    126..191
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    126..191
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    240..308
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    240..308
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    240..305
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    366..428
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    375..425
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    375..425
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    435..437
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="Important for receptor activation.
                     /evidence=ECO:0000250|UniProtKB:O14842; propagated from
                     UniProtKB/Swiss-Prot (Q8K3T4.1); other site"
     misc_feature    459..461
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K3T4.1); glycosylation site"
     misc_feature    516..518
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="Important for receptor activation.
                     /evidence=ECO:0000250|UniProtKB:O14842; propagated from
                     UniProtKB/Swiss-Prot (Q8K3T4.1); other site"
     misc_feature    537..602
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    540..611
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    540..611
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    669..737
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    669..737
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    672..746
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
     misc_feature    765..842
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    765..842
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    771..839
                     /gene="Ffar1"
                     /gene_synonym="Gpr40"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3T4.1);
                     transmembrane region"
ORIGIN      
        1 ccatggacct gcccccacag ctctccttcg ctctctatgt atcagccttt gcactaggct
       61 ttccattgaa cttgttagcc atccgaggtg cagtgtccca cgcgaaactg cgactcaccc
      121 ccagcttggt ctacactctc catttggcct gctctgacct cctactggcc atcaccctgc
      181 ccctgaaggc tgtggaggcc ctggcttctg gggtctggcc cctgccactc cccttctgcc
      241 cagtctttgc cttggcccac tttgcgcccc tctatgcagg tggaggcttc ctggctgctc
      301 tcagtgctgg ccgctacctg ggagctgcct tcccctttgg ataccaagcc atccggaggc
      361 cctgctattc ctggggtgtg tgtgtggcta tatgggccct tgtcctttgc cacctgggac
      421 tggctcttgg cttggaggct cccagaggct gggtggataa caccaccagt tccctgggca
      481 tcaacatacc cgtgaatggc tccccggtct gcctggaagc gtgggatcct gactctgccc
      541 gccctgcccg actcagtttc tcgattctgc tcttctttct gcccttggtt atcactgctt
      601 tctgctatgt gggctgcctc cgggccctgg tgcactcggg cctgagccac aaacggaagc
      661 tcagggcagc ttgggtggct ggaggagcac ttctcacact cctgctctgc ctggggccct
      721 ataatgcttc caatgtggct agtttcataa acccggactt agaaggctcc tggaggaagt
      781 tggggctcat cacaggagcc tggagtgtgg tgctcaaccc actggtcact ggctacttgg
      841 gaacaggtcc tggacagggg acaatatgtg tgaccaggac tccaagaggg acaattcaga
      901 agtag
//
LOCUS       NM_175591               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace-amine-associated receptor 7d (Taar7d),
            mRNA.
ACCESSION   NM_175591
VERSION     NM_175591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Guo,L., Cheng,J., Lian,S., Liu,Q., Lu,Y., Zheng,Y., Zhu,K.,
            Zhang,M., Kong,Y., Zhang,C., Rong,N., Zhuang,Y., Fang,G., Jiang,J.,
            Zhang,T., Han,X., Liu,Z., Xia,M., Liu,S., Zhang,L., Liberles,S.D.,
            Yu,X., Xu,Y., Yang,F., Li,Q. and Sun,J.P.
  TITLE     Structural basis of amine odorant perception by a mammal olfactory
            receptor
  JOURNAL   Nature 618 (7963), 193-200 (2023)
   PUBMED   37225986
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Ferrero,D.M., Wacker,D., Roque,M.A., Baldwin,M.W., Stevens,R.C. and
            Liberles,S.D.
  TITLE     Agonists for 13 trace amine-associated receptors provide insight
            into the molecular basis of odor selectivity
  JOURNAL   ACS Chem Biol 7 (7), 1184-1189 (2012)
   PUBMED   22545963
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Lewin,A.H.
  TITLE     Receptors of mammalian trace amines
  JOURNAL   AAPS J 8 (1), E138-E145 (2006)
   PUBMED   16584120
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   6  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702321.1.
            
            On Nov 18, 2005 this sequence version replaced NM_175591.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="trace-amine-associated receptor 7d"
                     /db_xref="GeneID:294134"
                     /db_xref="RGD:631395"
     CDS             1..1077
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="taR-15; taR-7d; trace amine receptor 7d;
                     trace-amine-associated receptor 7c; trace amine receptor
                     15"
                     /codon_start=1
                     /product="trace amine-associated receptor 7d"
                     /protein_id="NP_783181.2"
                     /db_xref="GeneID:294134"
                     /db_xref="RGD:631395"
                     /translation="MRVDDDRFPWDQDSILSRDLLSASSLQLCYENLNRSCVRSPYSP
                     GPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADLLVGLTVMP
                     FSMVRSVEGCWYFGDTYCKLHTSFDVSFCYCSLFHLCFISVDRYIAVSDPLIYPTRFT
                     ASVSGKCITFSWLLSIIYGFPLIYTGASEAGLEDLVSALTCVGGCQIPMNQKFVLINF
                     LLFLVPTLVMMTVYSKIFLIARQQAQNIEKMRKQTARASESYKDRVCKRERKAAKTLG
                     IAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILIWIVYYNSSMNPLIYAFFYPWFR
                     KATKLIVTGKILRENSSTINLFPE"
     misc_feature    100..102
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923X5.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    145..1008
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1008
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    148..222
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..312
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    361..429
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    367..429
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    496..546
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    499..561
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..699
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    637..699
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    814..882
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    823..885
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    913..990
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    928..999
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X5.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7d"
                     /gene_synonym="TA15; Taar7c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgtgtag atgatgaccg ttttccctgg gatcaggaca gcatcctgag cagagatctg
       61 ctctcagcct cgtctctcca gttgtgctat gagaacctga acagatcctg tgtcaggagc
      121 ccatactccc caggccctcg cctcatcctc tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaaccttct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttttggtggc gtctctggcc tgtgctgact tgttggtggg tttgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttggaga cacttactgt
      361 aaattacaca ctagttttga tgtctcgttc tgctattgtt ctctcttcca cttgtgcttc
      421 atctctgtgg atagatatat tgcagtcagt gaccccctca tctaccccac caggttcact
      481 gcatctgttt ctggcaagtg catcaccttc tcctggctcc tgtctatcat ctatggcttt
      541 cccctcattt acacaggagc aagtgaagct gggctggagg atctagtgag tgccctcacc
      601 tgtgtgggtg gctgtcaaat cccaatgaat caaaagtttg tccttattaa tttcctatta
      661 tttcttgtcc ccacgcttgt gatgatgact gtctactcta agatcttcct cattgcaagg
      721 cagcaagctc agaacatcga gaagatgagg aagcagactg ccagggcatc tgaaagctac
      781 aaggacaggg tgtgcaagag ggagaggaaa gcagccaaaa ccctgggtat tgcagtggct
      841 gctttcctcc tttcatggct gccatacttc attgactcca tcattgatgc cttcctgggg
      901 ttcataacac ccacgtatgt atatgaaatc ctaatttgga tagtttatta taactcatcc
      961 atgaaccctt tgatttatgc tttcttctat ccttggtttc gaaaagcaac caaactcatt
     1021 gtcactggca aaatcttgag agaaaattcc tcaaccatca atttgttccc tgagtag
//
LOCUS       NM_023099               1134 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 27 (Gpr27), mRNA.
ACCESSION   NM_023099
VERSION     NM_023099.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Dolanc,D., Zorec,T.M., Smole,Z., Maver,A., Horvat,A., Pillaiyar,T.,
            Trkov Bobnar,S., Vardjan,N., Kreft,M., Chowdhury,H.H. and Zorec,R.
  TITLE     The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3
            Embryonic Cells and Astrocytes
  JOURNAL   Cells 11 (6), 1009 (2022)
   PUBMED   35326460
  REMARK    GeneRIF: The Activation of GPR27 Increases Cytosolic L-Lactate in
            3T3 Embryonic Cells and Astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Ku,G.M., Pappalardo,Z., Luo,C.C., German,M.S. and McManus,M.T.
  TITLE     An siRNA screen in pancreatic beta cells reveals a role for Gpr27
            in insulin production
  JOURNAL   PLoS Genet 8 (1), e1002449 (2012)
   PUBMED   22253604
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Shen,P. and Howlett,G.J.
  TITLE     Two coding regions closely linked to the rat apolipoprotein E gene:
            nucleotide sequences of rat apolipoprotein C-I and ECL cDNA
  JOURNAL   Arch Biochem Biophys 297 (2), 345-353 (1992)
   PUBMED   1379790
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB040802.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB040802.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1134
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="G protein-coupled receptor 27"
                     /db_xref="GeneID:65275"
                     /db_xref="RGD:71067"
     CDS             1..1134
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="super conserved receptor expressed in brain 1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 27"
                     /protein_id="NP_075587.1"
                     /db_xref="GeneID:65275"
                     /db_xref="RGD:71067"
                     /translation="MANASEPGGGGGGAEAAALGLRLATLSLLLCVSLAGNVLFALLI
                     VRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPGALGCKLLAFL
                     AALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPV
                     LDGGGADDEDAPCALEQRPDGAPGALGFLLLLAAVVGATHLVYLRLLFFIHDRRKMRP
                     ARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLE
                     EFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAG
                     INPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL"
     misc_feature    7..9
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJH3.1); glycosylation site"
     misc_feature    58..1053
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    58..1053
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    64..138
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    64..138
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    73..135
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    163..231
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    163..231
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    169..231
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    289..357
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    289..357
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    295..357
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    421..483
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    427..477
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    427..477
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    547..618
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    547..618
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    550..612
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    853..921
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    853..921
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    862..924
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     misc_feature    955..1032
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    955..1032
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    967..1029
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJH3.1);
                     transmembrane region"
     exon            1..1134
                     /gene="Gpr27"
                     /gene_synonym="Sreb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgaacg ctagtgagcc gggcggcggc ggcggcgggg ccgaggctgc cgcgctgggc
       61 ctcaggctgg ccacactcag cctgctgctg tgcgtgagcc tggcgggcaa cgtgctgttc
      121 gctctgctca tcgtgaggga gcgcagcctg caccgcgcgc cttactacct gctgctcgac
      181 ctgtgcctgg ccgacgggct gcgcgcgctc gcctgtctcc cggccgtcat gctggctgcg
      241 cggcgcgcgg cagccgcggc ggggacgcct ccgggtgcgc tgggctgcaa gctgctggcc
      301 ttcctggccg cgctcttctg cttccacgcg gccttcctgc tgctgggcgt gggcgtcacc
      361 cgctacctgg ccatcgctca ccaccgcttc tatgccgagc gcctggccgg ctggccgtgc
      421 gccgcgatgc tggtgtgcgc cgcctgggcg ctggctttgg ccgcggcctt cccgccggtg
      481 ctggacggcg gtggcgcgga cgacgaggat gcgccgtgcg ccctggagca gcggcccgac
      541 ggcgccccgg gtgcgctagg cttcctgctg ctcctggccg cggtggtggg cgccacgcac
      601 ctcgtctacc ttcgcctgct cttcttcatc cacgaccgcc gcaagatgcg gcccgcacgc
      661 ctggtgcccg ccgtcagcca cgactggacc ttccacggcc cgggcgccac cggtcaagcg
      721 gccgccaact ggacggcggg cttcggccgc gggcccacgc cacctgcgct cgtgggcatc
      781 aggcctgcag gcccgggccg cggagcccgg cgcctcctgg tgctggagga attcaagacg
      841 gagaagaggc tgtgcaagat gttctacgcc atcacgctgc tcttcctgct cctctggggg
      901 ccctatgtgg ttgccagtta cctgcgcgtc ctggtgcggc ccggagctgt cccgcaggcc
      961 tacctgacag cctcggtgtg gctgacattc gcacaggccg gcatcaaccc cgtggtgtgt
     1021 ttcctcttca accgggagct gagggactgt ttcagagccc agttcccctg ttgccagagc
     1081 ccccaggcca cgcaggccac cctcccctgc gacctgaaag gcattggttt gtga
//
LOCUS       NM_138917                876 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus F-box protein 6 (Fbxo6), mRNA.
ACCESSION   NM_138917
VERSION     NM_138917.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Groisman,B., Shenkman,M., Ron,E. and Lederkremer,G.Z.
  TITLE     Mannose trimming is required for delivery of a glycoprotein from
            EDEM1 to XTP3-B and to late endoplasmic reticulum-associated
            degradation steps
  JOURNAL   J Biol Chem 286 (2), 1292-1300 (2011)
   PUBMED   21062743
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Zhang,Y.W., Brognard,J., Coughlin,C., You,Z., Dolled-Filhart,M.,
            Aslanian,A., Manning,G., Abraham,R.T. and Hunter,T.
  TITLE     The F box protein Fbx6 regulates Chk1 stability and cellular
            sensitivity to replication stress
  JOURNAL   Mol Cell 35 (4), 442-453 (2009)
   PUBMED   19716789
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Yoshida,Y., Adachi,E., Fukiya,K., Iwai,K. and Tanaka,K.
  TITLE     Glycoprotein-specific ubiquitin ligases recognize N-glycans in
            unfolded substrates
  JOURNAL   EMBO Rep 6 (3), 239-244 (2005)
   PUBMED   15723043
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF393484.1.
            
            On Jun 10, 2007 this sequence version replaced NM_138917.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393484.1, BC063148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box protein 6"
                     /db_xref="GeneID:192351"
                     /db_xref="RGD:620418"
     exon            1..280
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box/G-domain protein 2; F-box protein that
                     recognizes sugar chains 2; F-box only protein 6b; F-box
                     only protein 6 b"
                     /codon_start=1
                     /product="F-box only protein 6"
                     /protein_id="NP_620272.3"
                     /db_xref="GeneID:192351"
                     /db_xref="RGD:620418"
                     /translation="MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTL
                     WKRKSLREGFVTKDRDEPVDDWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEW
                     KVESLPGDHGTSFPDTKVKKYFVTSYGMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKD
                     WFAPRADCGCTYHLRVQLASADYIVLASFEPPPVTIEQWNDASWQEISHTFSNYPPGV
                     RHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNPAPARTLPEEDTSNRRKILSF
                     GSWEDLSP"
     misc_feature    22..270
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box domain found in F-box only proteins FBXO6,
                     FBXO44 and similar proteins; Region: F-box_FBXO6-like;
                     cd22168"
                     /db_xref="CDD:438939"
     misc_feature    22..270
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box domain found in F-box only proteins FBXO6,
                     FBXO44 and similar proteins; Region: F-box_FBXO6-like;
                     cd22168"
                     /db_xref="CDD:438939"
     misc_feature    order(22..24,28..36,40..45,52..54,64..66,73..75,79..81,
                     85..90,94..96,103..120,124..129,223..225)
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Skp1 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438939"
     misc_feature    order(22..24,28..36,40..45,52..54,64..66,73..75,79..81,
                     85..90,94..96,103..120,124..129,223..225)
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Skp1 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438939"
     misc_feature    229..765
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box associated region; Region: FBA; pfam04300"
                     /db_xref="CDD:461255"
     misc_feature    229..765
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="F-box associated region; Region: FBA; pfam04300"
                     /db_xref="CDD:461255"
     misc_feature    766..768
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRD1; propagated from
                     UniProtKB/Swiss-Prot (Q923V4.1); phosphorylation site"
     misc_feature    823..825
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QZN4; propagated from
                     UniProtKB/Swiss-Prot (Q923V4.1); phosphorylation site"
     misc_feature    844..846
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q923V4.1); phosphorylation site"
     misc_feature    853..855
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q923V4.1); phosphorylation site"
     misc_feature    868..870
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q923V4.1); phosphorylation site"
     exon            281..407
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            408..503
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..639
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
     exon            640..876
                     /gene="Fbxo6"
                     /gene_synonym="Fbg2; Fbxo6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacatagct ccactgccat catggtcaac atcaacgagc tgccggagaa cattctactg
       61 gaactgttca cccacgtccc ggccccacag ctgctgcgca actgccgcct ggtctgcagc
      121 ctctggcgag acctcatcga tgtgatgacc ctctggaagc gcaagagcct tcgagagggc
      181 tttgtcacca aagaccggga cgagcctgtg gatgactgga agatcttcta tatcctgtgc
      241 agtctgcaaa ggaacctcct tcggaacccg tgtgccgaag agaacctgag atcatggcgg
      301 atagactcca atgggggaga tgagtggaag gtggagagcc tccctgggga ccacggcaca
      361 agctttcctg acaccaaggt caagaagtat tttgtcacct cttatgggat gtgcctcaag
      421 tcccagatgg tggacctcaa agccgagggc tactctgaaa agctgctgga caccgttcgg
      481 ccggacattg tggttaaaga ctggtttgcc ccacgagcag actgcggctg tacctatcac
      541 ctccgggtac agctggcctc tgccgactac attgtcctag cctcctttga gcctccgcct
      601 gtgaccatcg aacagtggaa tgacgccagc tggcaagaga tctcccacac cttctccaat
      661 taccctcctg gcgtccgtca catccttttt caacatgggg gcaaggacac acagttctgg
      721 aaaggctggt atggtccccg tgtcaccaac agcagcatca tcgtcagcca caggacagcc
      781 aagaaccccg cccctgccag aactctaccg gaggaagaca ctagtaatag gaggaagata
      841 ctcagctttg gctcctggga agacctaagc ccttag
//
LOCUS       NM_130816                678 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus fibroblast growth factor 11 (Fgf11), mRNA.
ACCESSION   NM_130816
VERSION     NM_130816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 678)
  AUTHORS   Olsen,S.K., Garbi,M., Zampieri,N., Eliseenkova,A.V., Ornitz,D.M.,
            Goldfarb,M. and Mohammadi,M.
  TITLE     Fibroblast growth factor (FGF) homologous factors share structural
            but not functional homology with FGFs
  JOURNAL   J Biol Chem 278 (36), 34226-34236 (2003)
   PUBMED   12815063
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB079263.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB079263.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..678
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /note="fibroblast growth factor 11"
                     /db_xref="GeneID:170632"
                     /db_xref="RGD:620162"
     CDS             1..678
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /note="fibroblast growth factor 1d"
                     /codon_start=1
                     /product="fibroblast growth factor 11"
                     /protein_id="NP_570829.1"
                     /db_xref="GeneID:170632"
                     /db_xref="RGD:620162"
                     /translation="MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLL
                     ILLSKVRLCGGRPTRQDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFT
                     HFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASA
                     LYRQRRSGRAWYLGLDKEGRVMKGNRVKKTKAAAHFVPKLLEVAVYREPSLHSVPETS
                     PSSPPAH"
     misc_feature    208..597
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /note="FGF domain, beta-trefoil fold, found in the
                     fibroblast growth factor 11 (FGF11)-like family; Region:
                     beta-trefoil_FGF11-like; cd23309"
                     /db_xref="CDD:466995"
     misc_feature    208..597
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /note="FGF domain, beta-trefoil fold, found in the
                     fibroblast growth factor 11 (FGF11)-like family; Region:
                     beta-trefoil_FGF11-like; cd23309"
                     /db_xref="CDD:466995"
     exon            1..193
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /inference="alignment:Splign:2.1.0"
     exon            194..304
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /inference="alignment:Splign:2.1.0"
     exon            305..408
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /inference="alignment:Splign:2.1.0"
     exon            409..607
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /inference="alignment:Splign:2.1.0"
     exon            608..678
                     /gene="Fgf11"
                     /gene_synonym="Fgf1d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcgt tggccagtag cctgatccga cagaagcggg aggtccgcga gcccgggggc
       61 agccggccgg tgtccgcgca gcggcgcgtg tgtccccgcg gtaccaagtc actttgccag
      121 aagcagctcc tcatcctgct gtccaaggtg cgactgtgcg gggggcggcc cacgcgacag
      181 gaccgcggcc cagagcctca gctcaaaggc atcgtcacca aactgttctg ccgccagggt
      241 ttctacctcc aggcgaatcc agatgggagc atccagggca ccccagagga caccagctcc
      301 ttcacccact tcaatctgat tcccgtgggg cttcgtgtgg tcaccatcca gagtgccaag
      361 ctgggtcact acatggccat gaatgctgag gggctattgt acagctcgcc gcatttcaca
      421 gcagagtgtc gctttaagga gtgcgtcttt gagaattact atgtcctgta tgcctccgct
      481 ctctaccgcc agcgtcgttc tggccgggcc tggtacctag gcctggacaa ggaaggccgg
      541 gtcatgaagg gaaaccgagt caagaagacc aaggcagctg cccactttgt gcccaagctc
      601 ctggaggtgg ccgtgtaccg ggagccttct ctccacagtg tccctgagac ttccccttcc
      661 agtccccctg cccattga
//
LOCUS       NM_175583               1044 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 4 (Taar4), mRNA.
ACCESSION   NM_175583
VERSION     NM_175583.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Staubert,C., Bohnekamp,J. and Schoneberg,T.
  TITLE     Determinants involved in subtype-specific functions of rat trace
            amine-associated receptors 1 and 4
  JOURNAL   Br J Pharmacol 168 (5), 1266-1278 (2013)
   PUBMED   23072560
  REMARK    GeneRIF: The different functionality of rat Taar subtypes 1 and 4
            mainly correlates with receptor's cell surface expression rather
            than with specific amino acid residues involved in ligand binding
            specificity.
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Staubert,C., Boselt,I., Bohnekamp,J., Rompler,H., Enard,W. and
            Schoneberg,T.
  TITLE     Structural and functional evolution of the trace amine-associated
            receptors TAAR3, TAAR4 and TAAR5 in primates
  JOURNAL   PLoS One 5 (6), e11133 (2010)
   PUBMED   20559446
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   4  (bases 1 to 1044)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380188.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1044
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="trace amine-associated receptor 4"
                     /db_xref="GeneID:294122"
                     /db_xref="RGD:631382"
     CDS             1..1044
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="trace amine receptor 4; trace amine receptor 2;
                     2-phenylethylamine receptor"
                     /codon_start=1
                     /product="trace amine-associated receptor 4"
                     /protein_id="NP_783173.1"
                     /db_xref="GeneID:294122"
                     /db_xref="RGD:631382"
                     /translation="MNSPDLWYSPETQFCFAAANNSCPRKARPALVVCAMYLVMIGAI
                     VMTMLGNMVVIISIAHFKQLHSPTNFLILSMATTDFLLSCVVMPFSMVRSIESCWYFG
                     DLFCKVHSCCDIMLCTTSIFHLCFISVDRHYAVCDPLHYVTQITVGVVGVFLLISWSV
                     PILFAFGLVFSELNLIGAEDFVAAIDCTGLCVLIFNKLWGVLASFIAFFLPGAIMVGI
                     YIHIFTVARKHARKIGPGPRTKRALSESKMKATSGKESKATKTLSIVMGVFVLCWLPF
                     FVLTITDPFIGFTTPEDLYNVFLWLGYFNSTFNPIIYGMFYPWFRKALRMIVTGTIFR
                     SDSSTSSLHPAHP"
     misc_feature    58..60
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y7.1); glycosylation site"
     misc_feature    100..972
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    100..972
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    103..183
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    103..183
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    112..174
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    202..282
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    202..282
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    208..270
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    316..408
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    316..408
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    order(325..327,337..342,349..354,577..579,598..600,
                     607..612,619..621,817..819,826..831,838..840,883..885,
                     895..897,907..909)
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    order(325..327,337..342,349..354,577..579,598..600,
                     607..612,619..621,817..819,826..831,838..840,883..885,
                     895..897,907..909)
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    331..387
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    442..513
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    442..513
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    448..510
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    523..564
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     Region: Extracellular Loop 2 (ECL2).
                     /evidence=ECO:0000250|UniProtKB:Q5QD04"
     misc_feature    586..675
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    586..675
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    592..654
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    757..849
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    757..849
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    781..843
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     misc_feature    874..951
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    874..951
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    889..951
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y7.1);
                     transmembrane region"
     exon            1..1044
                     /gene="Taar4"
                     /gene_synonym="Ta2; taR-2; taR-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaattcac ctgacctctg gtactcccca gaaacacagt tttgcttcgc cgctgcaaac
       61 aactcttgcc cgaggaaggc gaggcctgcg cttgtggtct gcgccatgta cctcgtcatg
      121 atcggagcga tagtgatgac catgctggga aacatggttg tgatcatctc cattgcccac
      181 ttcaagcagc tccactcccc gaccaacttc cttattctct ccatggctac cacagacttc
      241 ctgttgagct gcgtggtcat gcccttcagt atggtccggt ctatcgagtc gtgctggtac
      301 ttcggagacc tcttttgcaa agtccacagc tgctgtgaca tcatgctctg taccacctcc
      361 attttccacc tctgtttcat ctcagtggac cgccactatg ctgtctgtga cccactgcat
      421 tatgtcaccc aaatcaccgt cggcgtcgtg ggggtctttc tactcatcag ttggtctgtc
      481 cccatcctgt ttgcctttgg cctggtgttc tcagaattaa atttgattgg tgctgaggat
      541 tttgttgcag ccattgactg tacaggtttg tgtgtgttga tatttaacaa gctctgggga
      601 gtgctggctt cctttatagc tttctttctg cctggggcaa tcatggtggg gatttatata
      661 cacattttca cagttgcccg gaaacatgcc cggaaaattg gtccaggtcc taggacaaaa
      721 cgggccctct cagaaagcaa aatgaaggcc acatccggaa aggaaagcaa ggccaccaag
      781 actttgagca tagtcatggg agtatttgtg ctgtgttggc tgcccttctt cgtcttgaca
      841 atcacagatc ctttcattgg ttttacaacc cctgaagatt tgtataatgt cttcctctgg
      901 ctcggttatt ttaactccac tttcaacccc atcatatacg gcatgttcta tccttggttt
      961 cgaaaggccc tgaggatgat agtcacaggg acgatctttc gctctgactc ctctacctcc
     1021 agcttgcatc ctgcacatcc ttag
//
LOCUS       NM_001025149             951 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 137 (Tas2r137),
            mRNA.
ACCESSION   NM_001025149 XM_575440
VERSION     NM_001025149.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362733.1.
            
            On Jul 1, 2005 this sequence version replaced XM_575440.1.
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..951
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="taste receptor, type 2, member 137"
                     /db_xref="GeneID:500089"
                     /db_xref="RGD:1560602"
     CDS             1..951
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="T2R3; T2R11"
                     /codon_start=1
                     /product="taste receptor type 2 member 3"
                     /protein_id="NP_001020320.1"
                     /db_xref="GeneID:500089"
                     /db_xref="RGD:1560602"
                     /translation="MLGFTEGIFLVLTVTEFILGNLVNGFIVSVNGSHWFKSKKISLS
                     DFIITSLALFRIFLLWIIFTDSLIIVFSYHTHDSGIRMQLIDVFWTFTNHFSIWLISC
                     LSVFYCLKIATFSHPSFLWLKWRASRVVVGMLWGALVLSCVCTMSLMNEFKIYSALTG
                     SRDTQNMTEYIRLKRHEYNLMHVLGNLWKIPSLIVSLIAYFLLLLSLGKHTQQMQKYS
                     VGSRDQSAEAHRRAMRIILSFLLFFLFYFLSFVILSSSRFLPETKIARIIGVVITMSY
                     LVGDSLILILGNNKLKQTFVAILPCECGHPKPGSKRFFAS"
     misc_feature    19..888
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="mammalian taste receptor 2, subtype 3, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R3; cd15020"
                     /db_xref="CDD:320148"
     misc_feature    19..888
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="mammalian taste receptor 2, subtype 3, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R3; cd15020"
                     /db_xref="CDD:320148"
     misc_feature    22..99
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320148"
     misc_feature    22..99
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320148"
     misc_feature    22..84
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320148"
     misc_feature    133..207
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320148"
     misc_feature    151..213
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    247..315
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320148"
     misc_feature    247..315
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320148"
     misc_feature    259..321
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    394..444
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320148"
     misc_feature    394..444
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320148"
     misc_feature    496..498
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET7.1); glycosylation site"
     misc_feature    532..603
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320148"
     misc_feature    532..603
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320148"
     misc_feature    559..621
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    676..753
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320148"
     misc_feature    676..753
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320148"
     misc_feature    703..765
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     misc_feature    787..864
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320148"
     misc_feature    787..864
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320148"
     misc_feature    799..861
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET7.1);
                     transmembrane region"
     exon            1..951
                     /gene="Tas2r137"
                     /gene_synonym="RGD1560602; Tas2r3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttgggat tcactgaagg gatatttctg gttctgactg tcaccgagtt tattcttgga
       61 aatctggtga acggtttcat tgtgtcagtc aatggcagcc attggttcaa gagcaagaag
      121 atttctttgt ctgacttcat cattaccagc ttggccctct tcaggatctt tctgctgtgg
      181 atcatcttta ctgatagcct cataatagtg ttctcttacc acacccacga ctcagggata
      241 aggatgcaac ttattgatgt tttctggaca tttacaaacc acttcagtat ttggcttatc
      301 tcctgtctca gtgttttcta ctgcctgaaa atagccactt tctcccaccc ctcattcctc
      361 tggctcaaat ggagagcttc tagagtggtt gttgggatgc tgtggggtgc actggtctta
      421 tcctgtgtct gcaccatgtc tctgatgaat gaatttaaga tctattctgc cctcactgga
      481 agcagagaca cacagaatat gactgaatat atcagattga agagacatga atataatctg
      541 atgcatgttc ttgggaatct gtggaagatc ccttccttaa tcgtttccct gattgcctac
      601 tttctgctcc ttctctctct ggggaagcac acacagcaga tgcagaaata cagtgttggc
      661 tccagagatc agagtgcgga ggcccacagg agagccatga ggatcatcct ttcctttctc
      721 ttattcttcc tattctactt tctttccttt gtaattttgt catccagtcg ttttctacca
      781 gaaaccaaga ttgccaggat aattggagta gtaattacaa tgtcatacct tgtgggtgat
      841 tcattaattc ttattttagg taacaacaag ctgaagcaga catttgtagc catactccca
      901 tgtgagtgtg gtcatccaaa gcctggatct aagaggttct ttgcttcata a
//
LOCUS       NM_001109329            1449 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus PRAME family member 8 like 1 (Pramef8l1), mRNA.
ACCESSION   NM_001109329 XM_001069875 XM_577323
VERSION     NM_001109329.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1449)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH474196.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_577323.2, XM_001069875.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1449
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1449
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /note="PRAME family member 8 like 1"
                     /db_xref="GeneID:501899"
                     /db_xref="RGD:1561226"
     CDS             1..1449
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /codon_start=1
                     /product="uncharacterized protein LOC501899"
                     /protein_id="NP_001102799.1"
                     /db_xref="GeneID:501899"
                     /db_xref="RGD:1561226"
                     /translation="MSFQTPPTLQKLARQTLLRNEAVAMSCVGELPIVLFPALFKEAF
                     EGRHINLVKEMVAAWPFPCLPVGALMKTPNAETLQAVLDGVDMRLTRKFHPRRIKLQV
                     LDLRNVKHAFWNTWTGAEDCSCSAENLEEKQVVKVFPRYALRRQRVKVITELSIFSCL
                     EEQQACFLKWAQERMGSLYFCCTKMKIWDLPVCVIREILNVFDPQHITELELHTEWTL
                     LELEHFAPYFGQMRNLRKVFLEPFHKVTLSNRNETRDREAKCIKKFISQFSKFNCLQH
                     LCMFCTHFLRDHMNQVLGCLMTPLETLSVTCCVISQNDLDSFSCCLSLFHLKHLDLRG
                     VVLHDLDVMPLRVLLEKVADTLETLDLQWCRMKNSQLYALLPALRHCSQLTTVKFYSN
                     KFSMPILKDLLQHTANWSKVNVEQYPAPQECYDDSSQVSVERFSQLCHELMDTHRAIR
                     QPKNISFATEICYTCGERCVYHNGPRLCCCLQ"
     misc_feature    <595..>1209
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <595..>1209
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     exon            1..287
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /inference="alignment:Splign:2.1.0"
     exon            288..881
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1449
                     /gene="Pramef8l1"
                     /gene_synonym="RGD1561226"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagttttc agaccccacc cacactccag aagctggcaa ggcaaactct gctgagaaat
       61 gaggctgtgg ccatgtcctg tgtgggggag ctgcctattg tgctcttccc agcactgttc
      121 aaggaggcat tcgagggcag acacatcaac ctcgtgaagg aaatggtggc agcttggcct
      181 ttcccctgtc tccctgtggg ggcattgatg aagacaccta atgcagaaac cttgcaggct
      241 gtgctagatg gagtagacat gcgactgaca agaaagtttc accccaggag gataaaacta
      301 caggtccttg atctgagaaa tgtgaagcat gccttctgga acacatggac tggagcagag
      361 gactgcagct gttcagcaga gaacttggag gaaaagcaag tagtgaaggt ctttcctaga
      421 tatgcactga ggcggcaacg tgtgaaagtc ataactgaac tgtccatctt ttcctgcctc
      481 gaagaacaac aagcatgctt cttaaagtgg gcccaagaaa gaatgggctc cctatatttc
      541 tgctgtacaa agatgaagat ctgggatttg ccagtctgtg ttatcagaga gatcttgaat
      601 gtttttgatc cacagcatat cacagaatta gaactgcata ctgaatggac cctgttagag
      661 ctggaacatt ttgctcccta ctttggacag atgagaaatc ttcgcaaagt cttcctggaa
      721 cccttccaca aggtgacctt gtctaataga aatgaaacaa gggacagaga agccaagtgt
      781 atcaagaagt ttatatctca gttttcaaaa ttcaattgtc tccagcatct ctgcatgttc
      841 tgcacccatt ttcttagaga tcatatgaat caagtcctag ggtgcctgat gactcctttg
      901 gaaactctct cagttacttg ctgtgtaatt tcacagaacg acttggattc cttctcctgc
      961 tgtctgagcc tctttcacct aaaacatctg gatttgagag gagtggtttt acatgatttg
     1021 gatgttatgc ctctgagagt tctcctagag aaagtggcag acactcttga gactctggat
     1081 ttgcagtggt gtaggatgaa gaactctcag ctttatgccc tcctacctgc cctcagacat
     1141 tgctctcagc tcaccacagt caagttctac agcaacaaat tctccatgcc cattctgaag
     1201 gacctgttgc agcacacagc caactggagc aaggtgaacg tggaacaata ccctgcccct
     1261 caggagtgct atgatgactc ctctcaagtt tctgtagaaa gattttccca actttgtcat
     1321 gagctcatgg atacacacag ggcaataagg cagcccaaga acatctcctt tgctacagaa
     1381 atctgttata catgtggtga gcgctgtgtc tatcacaatg ggcccaggct ttgttgttgc
     1441 ttgcagtaa
//
LOCUS       NM_001008310            1431 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus relaxin family peptide receptor 3 (Rxfp3), mRNA.
ACCESSION   NM_001008310 XM_226835
VERSION     NM_001008310.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Golyszny,M., Zielinski,M. and Obuchowicz,E.
  TITLE     Acute Stress Affects the Relaxin/Insulin-Like Family Peptide
            Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats
  JOURNAL   Dev Psychobiol 66 (6), e22523 (2024)
   PUBMED   38970242
  REMARK    GeneRIF: Acute Stress Affects the Relaxin/Insulin-Like Family
            Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar
            Rats.
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Vafaei,Z., Khodagholi,F., Nategh,M., Nikseresht,S.,
            Hashemirad,S.R., Raise-Abdullahi,P., Vafaei,A.A. and Motamedi,F.
  TITLE     Involvement of relaxin-family peptide-3 receptor (RXFP3) in the
            ventral dentate gyrus of the hippocampus in spatial and fear memory
            in rats
  JOURNAL   Peptides 178, 171244 (2024)
   PUBMED   38788901
  REMARK    GeneRIF: Involvement of relaxin-family peptide-3 receptor (RXFP3)
            in the ventral dentate gyrus of the hippocampus in spatial and fear
            memory in rats.
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Kania,A., Szlaga,A., Sambak,P., Gugula,A., Blasiak,E., Micioni Di
            Bonaventura,M.V., Hossain,M.A., Cifani,C., Hess,G., Gundlach,A.L.
            and Blasiak,A.
  TITLE     RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via
            M-like Current Activation and Contributes to Binge Eating Behavior
  JOURNAL   J Neurosci 40 (28), 5362-5375 (2020)
   PUBMED   32532885
  REMARK    GeneRIF: RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular
            Neurons via M-like Current Activation and Contributes to Binge
            Eating Behavior.
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Furuya,W.I., Dhingra,R.R., Gundlach,A.L., Hossain,M.A. and
            Dutschmann,M.
  TITLE     Relaxin-3 receptor (RXFP3) activation in the nucleus of the
            solitary tract modulates respiratory rate and the arterial
            chemoreceptor reflex in rat
  JOURNAL   Respir Physiol Neurobiol 271, 103310 (2020)
   PUBMED   31568840
  REMARK    GeneRIF: Activation of RXFP3 in the nucleus of the solitary tract
            selectively modulates respiration.
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Zhang,X., Pan,L., Yang,K., Fu,Y., Liu,Y., Chen,W., Ma,X. and Yin,X.
  TITLE     Alterations of relaxin and its receptor system components in
            experimental diabetic cardiomyopathy rats
  JOURNAL   Cell Tissue Res 370 (2), 297-304 (2017)
   PUBMED   28776188
  REMARK    GeneRIF: Relaxin-1 mRNA in the hearts of diabetic rats was
            significantly increased and that relaxin-3 mRNA expression at
            different time points was decreased. In addition, significant
            down-regulation of the mRNA expression of RXFP1 and RXFP3 was
            observed at 4 weeks after Streptozocin.
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Ma,S., Bonaventure,P., Ferraro,T., Shen,P.J., Burazin,T.C.,
            Bathgate,R.A., Liu,C., Tregear,G.W., Sutton,S.W. and Gundlach,A.L.
  TITLE     Relaxin-3 in GABA projection neurons of nucleus incertus suggests
            widespread influence on forebrain circuits via G-protein-coupled
            receptor-135 in the rat
  JOURNAL   Neuroscience 144 (1), 165-190 (2007)
   PUBMED   17071007
  REMARK    GeneRIF: RLX3 is the endogenous ligand for GPCR135 in rat brain
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   McGowan,B.M., Stanley,S.A., Smith,K.L., Minnion,J.S., Donovan,J.,
            Thompson,E.L., Patterson,M., Connolly,M.M., Abbott,C.R.,
            Small,C.J., Gardiner,J.V., Ghatei,M.A. and Bloom,S.R.
  TITLE     Effects of acute and chronic relaxin-3 on food intake and energy
            expenditure in rats
  JOURNAL   Regul Pept 136 (1-3), 72-77 (2006)
   PUBMED   16764952
  REMARK    GeneRIF: relaxin-3 and GPCR153 have roles in food intake and energy
            expenditure in rats
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Tanaka,M., Iijima,N., Miyamoto,Y., Fukusumi,S., Itoh,Y., Ozawa,H.
            and Ibata,Y.
  TITLE     Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond
            to stress
  JOURNAL   Eur J Neurosci 21 (6), 1659-1670 (2005)
   PUBMED   15845093
  REMARK    GeneRIF: We then confirmed that c-Fos was induced in 60% of relaxin
            3 neurons in the nucleus incertus (NI) and the expression of
            relaxin 3 mRNA increased significantly in the NI after
            water-restraint stress.
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Chen,J., Kuei,C., Sutton,S.W., Bonaventure,P., Nepomuceno,D.,
            Eriste,E., Sillard,R., Lovenberg,T.W. and Liu,C.
  TITLE     Pharmacological characterization of relaxin-3/INSL7 receptors
            GPCR135 and GPCR142 from different mammalian species
  JOURNAL   J Pharmacol Exp Ther 312 (1), 83-95 (2005)
   PUBMED   15367576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY633764.1.
            
            On Dec 16, 2004 this sequence version replaced XM_226835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY633764.1, AY633763.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="relaxin family peptide receptor 3"
                     /db_xref="GeneID:294807"
                     /db_xref="RGD:1311550"
     CDS             1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="relaxin-3/INSL7 receptor 1; G-protein coupled
                     receptor SALPR; relaxin/insulin-like family peptide
                     receptor 3"
                     /codon_start=1
                     /product="relaxin-3 receptor 1"
                     /protein_id="NP_001008311.1"
                     /db_xref="GeneID:294807"
                     /db_xref="RGD:1311550"
                     /translation="MPKAHLSMQVASATTAAPMSKAAAGDELSGFFGLIPDLLEVANR
                     SSNASLQLQDLWWELGLELPDGAAPGHPPGSGGAESADTEARVRILISAVYWVVCALG
                     LAGNLLVLYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKA
                     MCKIVSMVTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGHGRGDCCGQSLGESCC
                     FSAKVLCGLIWASAAIASLPNVIFSTTINVLGEELCLMHFPDKLLGWDRQFWLGLYHL
                     QKVLLGFLLPLSIISLCYLLLVRFISDRRVVGTTDGATAPGGSLSTAGARRRSKVTKS
                     VTIVVLSFFLCWLPNQALTTWSILIKFNVVPFSQEYFQCQVYAFPVSVCLAHSNSCLN
                     PILYCLVRREFRKALKNLLWRIASPSLTSMRPFTATTKPEPEDHGLQALAPLNATAEP
                     DLIYYPPGVVVYSGGRYDLLPSSSAY"
     misc_feature    265..1221
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    265..1221
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    271..345
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    271..345
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    373..438
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    373..438
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    487..555
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    487..555
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    667..717
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    667..717
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    814..885
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    814..885
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    994..1062
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    994..1062
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1123..1200
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1123..1200
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccaaag cgcacctgag catgcaagtg gcttctgcaa ccaccgcagc ccccatgagt
       61 aaggcagctg cgggtgatga gctctccgga ttcttcggcc tgatcccaga cttgctggag
      121 gttgccaaca ggagcagcaa tgcgtcgctg cagcttcagg acttgtggtg ggagctgggg
      181 ctggagttgc ccgacggtgc ggcgcctggg catcccccgg gcagcggtgg ggcagagagc
      241 gcggacacag aggccagggt acggatcctc atcagcgccg tttactgggt ggtttgtgcc
      301 ctgggactgg ctggcaacct gctggttctc tacctgatga agagcaaaca gggctggcgc
      361 aaatcctcca ttaacctctt tgtcactaac ctggcgctga ctgactttca gtttgtgctc
      421 actctgccct tctgggcggt ggagaacgca ctagatttca agtggccctt tggcaaggcc
      481 atgtgtaaga tcgtatctat ggtgacatcc atgaacatgt atgccagcgt cttctttctc
      541 actgctatga gtgtggcgcg ctaccactcg gtggcctcag ctctcaagag ccatcggacc
      601 cgcgggcatg gccgtggcga ctgctgcggc cagagcttgg gggagagctg ctgtttctca
      661 gccaaggtgc tgtgtggatt gatctgggct tctgccgcga tagcttcgct gcccaatgtc
      721 attttttcta ccaccatcaa tgtgttgggc gaggagctgt gcctcatgca ctttccggac
      781 aagctcctgg gttgggaccg gcagttctgg ctgggtttgt accacctgca gaaggtgctg
      841 ctgggcttcc tgctgccgct gagcatcatc agtttgtgtt acctgttgct cgtgcgcttc
      901 atctccgacc gccgcgtagt ggggacaacg gatggagcaa cagcgcctgg ggggagcctg
      961 agtacagccg gcgctcggag acgctccaag gtcaccaagt cggtgaccat cgtagtcctt
     1021 tccttcttct tatgttggct gcccaaccaa gcgctcacca cctggagcat cctcatcaag
     1081 ttcaacgtag tgcccttcag tcaggagtac tttcagtgcc aagtgtacgc gttcccagtc
     1141 agcgtgtgcc tggcacactc caacagctgc ctcaacccca tcctctactg cttagtgcgc
     1201 cgcgagttcc gcaaggcgct caagaacctg ctgtggcgta tagcatcgcc ttcgctcacc
     1261 agcatgcgcc ccttcaccgc caccaccaag ccagaacctg aagatcacgg gctgcaggcc
     1321 ctggcgccac ttaatgctac tgcagagcct gacctgatct actatccacc cggtgtggtg
     1381 gtctacagcg gaggtcgcta cgaccttctc cctagcagct ctgcctactg a
//
LOCUS       NM_001109394             660 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus claudin 20 (Cldn20), mRNA.
ACCESSION   NM_001109394 XM_001054648
VERSION     NM_001109394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 660)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   2  (bases 1 to 660)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474052.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001054648.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..660
                     /gene="Cldn20"
                     /note="claudin 20"
                     /db_xref="GeneID:680178"
                     /db_xref="RGD:1595446"
     CDS             1..660
                     /gene="Cldn20"
                     /codon_start=1
                     /product="claudin-20"
                     /protein_id="NP_001102864.1"
                     /db_xref="GeneID:680178"
                     /db_xref="RGD:1595446"
                     /translation="MASAGLQLLAFILAVSGVSGVLAATLLPNWKVNADAGSTIVTAI
                     VQVHGLWMDCTWYSTGMFSCTLKYSILSLPVYVQAARATMVLACILSALGICTAIVGM
                     KCTHLGGDAHTKSHISFAGGVCFITAGISALIPTVWYTKEIISNFLDLTVPESHKYEP
                     GGAVYIGFISAMLLLIAGIIFCISYIKKNQEPWIYPPKQRLTSTWQPKNRLAYNLKDY
                     V"
     misc_feature    13..543
                     /gene="Cldn20"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    13..543
                     /gene="Cldn20"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            1..660
                     /gene="Cldn20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctcgg ccggtctcca gctcctggct ttcatcctgg ctgtgtctgg ggtctctgga
       61 gtacttgctg ccactctgct gccaaactgg aaggttaatg cagatgcagg ctccaccatt
      121 gtaactgcta ttgtacaggt acatgggttg tggatggact gcacgtggta cagcactggg
      181 atgtttagct gcactctgaa atactccatt ctgtcgctcc ccgtctatgt gcaggctgcg
      241 agggctacca tggtcctggc ctgcattctg tctgccttgg ggatttgtac tgcgatagta
      301 ggaatgaaat gcactcactt aggaggagac gcacacacca agagtcacat ttcctttgct
      361 ggaggagtct gcttcatcac cgcagggatc tctgctttaa tcccaacagt gtggtacacc
      421 aaagagatca tatccaactt tttggatctg actgttccag aaagccacaa atatgaacct
      481 ggaggagccg tgtacattgg gttcatttca gcgatgttac tacttatcgc tggtattatt
      541 ttctgcattt cttatataaa aaagaaccaa gaaccatgga tctaccctcc caagcagaga
      601 cttacctcta cctggcagcc aaagaacagg ttagcataca acctgaagga ttatgtgtaa
//
LOCUS       NM_001024319             912 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor type 2 member 7-like (Tas2r7l),
            mRNA.
ACCESSION   NM_001024319 XM_575388
VERSION     NM_001024319.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 912)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362742.1.
            
            On May 27, 2005 this sequence version replaced XM_575388.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..912
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="taste receptor type 2 member 7-like"
                     /db_xref="GeneID:500033"
                     /db_xref="RGD:1564521"
     CDS             1..912
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="putative taste receptor T2R22"
                     /codon_start=1
                     /product="taste receptor type 2 member 7-like"
                     /protein_id="NP_001019490.1"
                     /db_xref="GeneID:500033"
                     /db_xref="RGD:1564521"
                     /translation="MTFFFPAIYHMVIMTAEFLIGTTVNGFLIIVNCYDLFKSRAFPI
                     LPTLLMCTGLSRLGLQIMLMTQSFFSVFFPYSYEENIYSSKIMFVWMFFSSIGLWFAT
                     CLSVFYCLKISGFTQPWFLWLKFRISKLIFWLLLGSLLASLGTATVCIEVGFPLIEDG
                     YILRNTRLNNSNVKLMRNNNLLLINLTLLLPLTVFVMCTSMLFISLYKHMYRMRSESQ
                     RMSNARTEAHINALKTVTSFFCFFVSYFAAFMANMTFRIPYRSHQFFVVKEIMAAYPA
                     GHSVIIILSNSKFKDLFTRMICLQKEG"
     misc_feature    22..870
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..870
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    28..102
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    28..102
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    136..201
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    136..201
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..318
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    250..318
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    397..447
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    397..447
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    529..600
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    529..600
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    682..750
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    682..750
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    781..858
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    781..858
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..912
                     /gene="Tas2r7l"
                     /gene_synonym="RGD1564521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgactttct ttttcccagc tatttatcac atggtcatca tgacagcaga gttcctcata
       61 gggactacag tgaatggatt ccttatcatt gtgaactgct atgacttgtt caagagccga
      121 gcattcccga tcctgcctac cctcttgatg tgcacagggc tgtccagact cgggctgcag
      181 ataatgctga tgacacaaag cttcttctct gtgttctttc catactctta tgaggaaaat
      241 atttatagtt ccaagataat gttcgtttgg atgttcttca gctcaattgg cctctggttt
      301 gccacatgtc tttctgtctt ttactgcctc aagatttcag gcttcactca gccctggttt
      361 ctttggctga aattcagaat ttcaaagctc atattttggc tgcttctggg cagcttgctg
      421 gcctctttgg ggaccgcaac tgtgtgtata gaggtaggtt tccctttaat tgaggatggg
      481 tatatcctga ggaacacaag actaaataat agtaatgtca agctaatgag aaataacaac
      541 ttactcctca tcaacctgac cttactgctt cccctaactg tgtttgtgat gtgcacctct
      601 atgttattca tttctcttta caagcacatg taccggatgc gaagtgaatc tcagaggatg
      661 tcaaatgcca gaaccgaagc ccatataaat gcattaaaaa cagtgacatc attcttctgt
      721 ttctttgttt cttacttcgc tgccttcatg gcaaatatga catttagaat tccatacaga
      781 agtcatcagt tctttgtggt gaaggaaatc atggcagcat atcctgccgg ccactccgtc
      841 ataatcatct tgagtaactc taagttcaaa gacttattca cgagaatgat atgtctgcag
      901 aaggaagggt ga
//
LOCUS       NM_001107988            3783 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus von Willebrand factor A domain containing 5B1
            (Vwa5b1), mRNA.
ACCESSION   NM_001107988 XM_001070856 XM_233587
VERSION     NM_001107988.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233587.4, XM_001070856.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132299, SAMD00155312
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3783
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="von Willebrand factor A domain containing 5B1"
                     /db_xref="GeneID:313653"
                     /db_xref="RGD:1308559"
     exon            1..109
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    106..108
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="upstream in-frame stop codon"
     exon            110..271
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..3783
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 5B1"
                     /protein_id="NP_001101458.1"
                     /db_xref="GeneID:313653"
                     /db_xref="RGD:1308559"
                     /translation="MPGLLNCFTGAALPLTASDVTSYVSGYALGLTASLTYGNLEAQP
                     FQGLFVYPTDECTTVVGFEAVIADRVVTIQLRDKAKLDRSYLDVQSATVTGNLPEEEI
                     PITPGKVTLDEDLERILFVVNLGTIAPMENVTIFISTSSELPTLPSGAVRVLLPAICA
                     PTVHPFCAHRFGSSRQQPRGKDPHCFGTQSKDSYKRLCLATLLDTKVTNPMEYEFKFQ
                     LEIRGPCLLAGVESPTHEIRADAAPSAHSAKSIIITLAKKHTFDRPVEILLHPSEPHM
                     PHVLVEKGDMTLGEFYQHLKRKADFVRGTKKDNIAERKTEVIRKRLHKDIPHHSVIML
                     NFCPDLESVQPNPRRTHGEFIFLIDRSSSMSKTNIQCIKEAMLVALKSLMPACLFNVI
                     GFGSTFKTVFASSQIYNEENLALACECIQRMRADMGGTNIFSPLKWVLRQPLRQGHPR
                     LLFLITDGSVNNTGKVLELVRNHASSIRCYSFGIGPTVCYRLVKGLASVSKGSAEFLM
                     EGERLQPKMVKSLKKAMAPVLSDVTVEWVFPETTEALISPVSTSSLFPGERLVGYGIV
                     CDASLYISNSRSDKRRKYGMLHAQESSSSVFYHSQDEGLRPGSGNCAKNFNQGQTKDA
                     HPCNGDSLSHHGLDGSRRRRAYSTNQISSHKACSRATTASDPTGTTRRYPLRKAKVQD
                     LAHQSSSESQQWQIDLQPLLTRGHDPSQGPRLHGPGARRPSLLPQGCQPMRFSGPEPQ
                     AWSPVRELGLGSGRKSVLNSRSSEDLATEPPPFPSTLEPETSSDLEPTAELEEQAPYR
                     TATPSPVLGKVLVKGVCDNQHMQWEVSFELEPPALRREDTQNDDMWGETFHHLAARAI
                     IREFEHLAQREDEIELGSNRRYQVNAVHTSKACNVISKYTAFVPVDINKRQYLPTVVK
                     YHNSGALLSFRNLTRQWKGFSTGLRRSQSMLREHSSAAGDSKFQTLALHESLTSTFNK
                     TPSPGHEKYATAEGPPQNLSTSSLSSTKASEAIFGSRLILNKSRLLTRATKNFLSKSL
                     PKAPEVNPGSQSSDYVPLVSLQLASGAFLLNEVFCRTIQIPMEKLKWTSPFNCLRMSL
                     VTRRHDLKTQSPGDCTSLSSPPPPSDDISLKSGAKDSSDQESSELLEHTGKLWATVVA
                     LAWLEHSSASYIIEWELVAAKASSWVELQEVPEGRTLSTIKATARQLFVLLRHWDENL
                     EFNMLCYNPNYM"
     misc_feature    136..369
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="Vault protein inter-alpha-trypsin domain; Region:
                     VIT_2; pfam13757"
                     /db_xref="CDD:404621"
     misc_feature    136..369
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="Vault protein inter-alpha-trypsin domain; Region:
                     VIT_2; pfam13757"
                     /db_xref="CDD:404621"
     misc_feature    1180..1689
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="vWA_interalpha trypsin inhibitor (ITI): ITI is a
                     glycoprotein composed of three polypeptides- two heavy
                     chains and one light chain (bikunin). Bikunin confers the
                     protease-inhibitor function while the heavy chains are
                     involved in rendering stability to...; Region:
                     vWA_interalpha_trypsin_inhibitor; cd01461"
                     /db_xref="CDD:238738"
     misc_feature    1180..1689
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="vWA_interalpha trypsin inhibitor (ITI): ITI is a
                     glycoprotein composed of three polypeptides- two heavy
                     chains and one light chain (bikunin). Bikunin confers the
                     protease-inhibitor function while the heavy chains are
                     involved in rendering stability to...; Region:
                     vWA_interalpha_trypsin_inhibitor; cd01461"
                     /db_xref="CDD:238738"
     misc_feature    order(1207..1209,1213..1215,1219..1221,1420..1422,
                     1501..1503)
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="metal ion-dependent adhesion site (MIDAS); other
                     site"
                     /db_xref="CDD:238738"
     misc_feature    order(1207..1209,1213..1215,1219..1221,1420..1422,
                     1501..1503)
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /note="metal ion-dependent adhesion site (MIDAS); other
                     site"
                     /db_xref="CDD:238738"
     exon            272..415
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            416..671
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            672..817
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            818..949
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1074
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1251
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1362
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1565
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1680
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1866
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2038
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2229
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2431
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2749
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2887
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3013
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3088
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3158
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3276
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3783
                     /gene="Vwa5b1"
                     /gene_synonym="RGD1308559"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactttgacg gaaggatttg gctcccagac tgtggtttga gcttgagctc cctaaagaag
       61 agaaagggat ttctaggggt aacaagagga atgggacccc aaaactgaga ctctgagctg
      121 agcagcccca gaatgcctgg cctgttgaac tgcttcacgg gggcagccct gcctctcacc
      181 gcgtctgacg tcacctccta cgtcagcggc tatgccctgg gcctcacggc ctcccttacc
      241 tatggcaacc tggaggctca gcccttccaa ggtctcttcg tgtatccgac ggatgagtgc
      301 accacagtgg ttggtttcga agccgtcatt gctgaccgag ttgtgaccat acagctcaga
      361 gacaaagcca agctggacag aagctacttg gatgtccaat ccgccactgt cacagggaac
      421 cttccagaag aggagattcc catcacaccg ggaaaggtga ccttggatga ggatctggag
      481 cggattctgt tcgtggtcaa cctggggacc attgctccca tggaaaatgt caccatcttc
      541 atcagtacct cctcggaact ccccacgcta cccagcgggg ccgtgagggt ccttctgccg
      601 gccatctgtg ccccgaccgt gcacccattc tgcgcccaca ggtttggctc ctccagacaa
      661 cagccacgag gcaaagaccc acactgcttc ggcacccagt ccaaggactc ctataagagg
      721 ctgtgtctgg ccactctcct ggacacaaag gtgaccaacc caatggaata tgaattcaaa
      781 tttcagctgg aaatccgcgg gccatgtctg cttgcagggg tggagagtcc cactcatgaa
      841 atccgagcag atgcagcccc atcggcccac tcagccaaaa gcatcatcat caccttggcc
      901 aaaaaacata cctttgaccg gccggtggag atccttctcc accccagtga gccccacatg
      961 ccgcatgtcc tggtggagaa aggggacatg accctggggg aattctacca gcacttgaag
     1021 cgaaaagcag atttcgttag aggaacaaag aaggacaaca tcgctgagcg gaagacagaa
     1081 gtcatccgga agcgtctcca caaagacatt ccccaccact cagtcatcat gctcaacttc
     1141 tgtcctgacc tcgagtccgt gcagcccaac cccaggagga cccatgggga atttatcttc
     1201 ctcatcgaca ggagcagcag catgagcaag accaacatcc agtgcatcaa ggaggccatg
     1261 ttggtggccc ttaagagcct catgccagca tgcctcttca atgtcattgg tttcggatcc
     1321 acatttaaga cagtctttgc ttccagtcag atctacaatg aggagaactt ggccctggca
     1381 tgtgaatgca tccagagaat gcgagctgac atgggaggca ccaacatatt ctcccctctg
     1441 aagtgggtcc tccggcagcc actgcgccag ggtcacccac ggctcctctt cctgatcacc
     1501 gatgggtctg tgaacaacac cgggaaggtt ctggagctgg tgcggaatca tgcctcttct
     1561 atcaggtgct atagctttgg aattggaccc acggtctgct acagactggt aaaagggctg
     1621 gcgtctgtat ccaagggcag tgcagagttc ctgatggagg gggagcggct gcaaccaaag
     1681 atggtcaaat ccttgaagaa ggccatggcc ccagtgctga gcgacgtgac cgtggagtgg
     1741 gtttttcctg agaccacgga ggccctgatc tctcctgtca gcaccagctc ccttttccct
     1801 ggggaacggc tggtgggata tggcattgtg tgcgatgcct ccttgtacat ctccaattcc
     1861 agatctgaca aaagacgaaa gtatggcatg ctgcatgctc aggagtccag cagctctgtc
     1921 ttctaccact ctcaggacga gggactcagg ccaggcagcg gaaactgtgc caagaacttc
     1981 aaccaggggc agaccaaaga cgcccatcca tgcaatggag actccctctc ccatcacggt
     2041 ctggatggct cccggcgtcg gagggcatac agcactaatc agatctccag tcacaaggct
     2101 tgctcaaggg ccaccacagc cagcgacccc actgggacta ccaggagata cccacttcga
     2161 aaagccaagg tgcaagacct ggcccatcag agcagctcag agagccagca gtggcagatt
     2221 gatctgcagc cgctactcac cagaggccat gacccaagcc agggccccag acttcatggc
     2281 cctggagccc gcaggccttc ccttcttcct caaggctgcc agcccatgcg gttctctggc
     2341 ccggagcccc aggcctggag ccccgtgaga gagctgggtc ttggctccgg ccggaagtct
     2401 gtccttaaca gccgaagctc tgaggaccta gccacagagc cacccccttt tccctcgacc
     2461 ttggaaccag agacatcctc agacttggag cccacggctg aattagagga gcaagctccc
     2521 tacaggaccg ccacgccaag ccctgtgctg ggcaaagttt tggtcaaagg agtgtgtgac
     2581 aaccagcata tgcagtggga agtgagcttt gagctagaac ctccagccct gcggagggag
     2641 gacacacaga acgatgacat gtggggcgag actttccacc acctggcggc ccgcgccatc
     2701 atccgcgaat tcgagcatct ggcccagcgc gaggatgaga ttgagctggg gtccaatcgc
     2761 agataccagg tgaacgccgt gcacaccagc aaggcctgca acgtgatcag caagtacacg
     2821 gccttcgtgc cggtggacat aaacaagagg cagtacctgc ccacggtggt caagtaccac
     2881 aattctggtg ctctactcag cttccggaac ctgacccgac agtggaaagg cttctctact
     2941 ggccttagga ggtcccagag tatgctcaga gaacactcct cagctgcagg agacagcaaa
     3001 ttccagaccc tagccttaca tgaaagcctt acttcaacct tcaataagac cccatcccct
     3061 gggcatgaga agtatgctac agcagaaggt ccccctcaaa acctgtccac cagctctctg
     3121 tcctccacaa aggcctccga ggccatcttt ggatctaggt tgattctcaa caaatccagg
     3181 ctgctgaccc gagctaccaa aaactttctc agcaaatcat tgcccaaggc tccagaggta
     3241 aacccaggca gccagagctc tgactacgta ccactggtgt ctctgcagct ggcctcggga
     3301 gcctttttgc tcaatgaagt cttctgcagg accatccaaa tccccatgga gaaactcaag
     3361 tggacctcac ccttcaactg cctccgaatg tccctcgtca cccgccggca tgatttgaag
     3421 acccagagtc caggggactg caccagtctc tcctctccac ctccaccctc tgacgacatc
     3481 tccctaaagt ctggcgccaa agacagctca gaccaggagt ccagtgagct gctggagcac
     3541 acggggaagc tgtgggccac tgtggtggcg ctggcgtggc tggaacacag ctcagctagt
     3601 tacatcattg agtgggagct ggtggctgcc aaggcgagct cgtgggtaga gctgcaggag
     3661 gtgcccgagg gccgcacact gagcaccatc aaggccactg ctcgccagct gttcgtgctc
     3721 ctgcgacact gggatgagaa cctggagttc aatatgctct gttacaaccc aaattatatg
     3781 taa
//
LOCUS       NM_001004130            1446 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 39 (Krt39), mRNA.
ACCESSION   NM_001004130 XM_220946
VERSION     NM_001004130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004035.1.
            
            On Sep 5, 2004 this sequence version replaced XM_220946.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004035.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN09345329,
                                           SAMN16093044 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1446
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="keratin 39"
                     /db_xref="GeneID:303523"
                     /db_xref="RGD:1303032"
     CDS             1..1446
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="K39; CK-39; cytokeratin-39; type I hair keratin
                     KA35; keratin 39, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 39"
                     /protein_id="NP_001004130.1"
                     /db_xref="GeneID:303523"
                     /db_xref="RGD:1303032"
                     /translation="MDTKGSTVTISSSTPPQNCSGNTNVRTNSSNKSCYHDVQSTGHA
                     LQTPQGQGCRPSPCLYRCPNYLIRTYSFHPCPDDCSRCSDGINSHEKETMQILNERLA
                     SYLEKVRMLEGENADLEDKIQEECSKTLPILCPDYLSYYTTIEQLQQKILCTKAENSR
                     LVSQIDNTKLAADDLRAKYEAELSLRQLVEADANGLKQILDALTLSKADLEARVQSLT
                     EELLCLKTNHEEEINSLQCQLGDRINIEVTAAPSVDLNQILQKMRCQYESIVETNRKD
                     VEEWFNTQMEELNQQVVSSSQQQQCCQKDIIELRRTISALEVELQAQHRMRDSQECIL
                     AETEARYTALLAQIQSLIHNLEAQVAEIRSALQRQNQEYEVLLDIKSRLECEIATYRS
                     LLESLDGRLPCNPCTTTWEPSCQARAMECLTPVYTSISLPGIHKPCRASGPPSRILVK
                     ICTITKEIKDGKVISSHEHVQPCYITRPAKV"
     misc_feature    1..270
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Head"
     misc_feature    1..75
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    268..1200
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    268..1200
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    271..375
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Coil 1A"
     misc_feature    376..408
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Linker 1"
     misc_feature    409..711
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Coil 1B"
     misc_feature    712..759
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Linker 12"
     misc_feature    760..1191
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Coil 2"
     misc_feature    1015..1017
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (Q6IFW3.1); other site"
     misc_feature    1192..1443
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW3.1);
                     Region: Tail"
     exon            1..450
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            451..533
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            534..690
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            691..852
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            853..978
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1199
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1446
                     /gene="Krt39"
                     /gene_synonym="Ka35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatacca agggctctac agtgactatt tcttcttcga ccccacccca aaactgctct
       61 gggaatacaa atgtcaggac taactcttct aacaagagct gttatcatga tgttcagtca
      121 actggccatg ctctacaaac tccccagggc cagggctgtc gccccagccc ctgcctttat
      181 cgctgcccta actacttgat aagaacctac agcttccacc cctgtccgga tgactgcagc
      241 cggtgctctg acggcattaa cagtcatgag aaagagacca tgcagatttt gaacgaacgc
      301 cttgcaagct atctggaaaa ggtgcggatg ctggaaggag agaacgcgga cctagaggat
      361 aaaatccagg aggagtgcag caagacactc cccatcctgt gtcctgacta cctgtcctac
      421 tacaccacca tcgagcagct gcagcagaag atcttgtgta ccaaggctga aaattccaga
      481 ctggtctcac aaattgacaa caccaaactg gctgcagatg acttgagagc aaagtatgaa
      541 gctgaattgt ccctacgcca gctcgtggaa gccgacgcca atggcctgaa gcagatcctg
      601 gatgcactga ctctgagtaa ggctgatctg gaggctcgag tccagtctct gacggaggaa
      661 cttctgtgcc tcaaaacaaa ccatgaggag gaaattaatt ccttacagtg ccaacttggg
      721 gacagaatca acattgaagt aacagctgcc ccttctgttg atctaaatca aatcctacaa
      781 aaaatgagat gccagtatga gtccattgtg gagacaaacc gtaaagacgt agaagaatgg
      841 ttcaatacac agatggagga actgaatcaa caggtagtga gcagctctca acagcagcaa
      901 tgctgccaga aggacatcat agagctgaga cggaccataa gtgccctcga ggttgagctg
      961 caggcccagc atcgaatgag agattcccag gaatgcatcc tagcagagac agaggcccga
     1021 tacacagccc tgctggccca aatccagagt ctgatccata acctggaggc tcaggtagca
     1081 gaaatccgca gtgccctgca aagacagaac caggaatatg aagttctgct agacatcaag
     1141 tcccggctgg agtgtgagat agccacctac cgcagtcttc tggagagctt ggatggcagg
     1201 cttccctgta acccatgtac cactacatgg gagccatcct gccaggccag agctatggag
     1261 tgtcttaccc cagtttatac atctatatca ctccccggga ttcacaagcc ctgccgtgcc
     1321 tctggacccc catcccggat actggttaag atatgcacca tcaccaagga gatcaaggat
     1381 ggaaaggtca tttcttctca cgagcatgtg cagccttgct acatcaccag acctgccaaa
     1441 gtctag
//
LOCUS       NM_001008820            1368 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 35 (Krt35), mRNA.
ACCESSION   NM_001008820 XM_220970
VERSION     NM_001008820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004042.1.
            
            On Jan 5, 2005 this sequence version replaced XM_220970.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004042.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840107,
                                           SAMN12840108 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1368
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /note="keratin 35"
                     /db_xref="GeneID:287697"
                     /db_xref="RGD:1305300"
     CDS             1..1368
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /note="keratin complex 1, acidic, gene 2; type I hair
                     keratin KA30; keratin 35, type I"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha5"
                     /protein_id="NP_001008820.1"
                     /db_xref="GeneID:287697"
                     /db_xref="RGD:1305300"
                     /translation="MASKCFKASFSSGSLKSPGKAGGGSTRMSRMYSSSSCKLPSPSR
                     GARSFSVCSAGLGRGNYRLSSCLPALCLPTGGFATGYSMGGGWFGEGILTGNEKETMQ
                     SLNDRLASYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTMEELQKKTLC
                     SKAENARLVVQIDNAKLAADDFRTKYETEVSLRQLVEADINGLRRILDDLTLCKADLE
                     AQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLDEMRCQYETL
                     VENNRRDAEDWYDTQTEELNQQVVTSSEQLQSCQSDIIELRRTVNSLEIELQAQQSMR
                     DALDSTLAETEARYSSQLAQMQCLIGSVESQLGEIRADLERQNQEYQVLLDVRARLEC
                     EINTYRGLLESEDSKLPCNPCAPDYSPSKSCLPCLPAVSCSTGAARTTCSPRPVCVPC
                     PGGRF"
     misc_feature    286..1221
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    286..1221
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     exon            1..471
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..554
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..711
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..873
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..999
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1220
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1368
                     /gene="Krt35"
                     /gene_synonym="Ka30; Krt1-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttcca aatgcttcaa ggccagcttc tcctcaggat ctctgaagag cccaggcaaa
       61 gctggagggg gatccactcg catgtctagg atgtactcca gtagctcttg caagctgccc
      121 agtccttccc ggggagcccg gagtttctct gtgtgttctg ccggcctggg tagaggcaat
      181 tacaggctat ccagctgcct cccagctctc tgcctcccaa caggaggctt tgccaccggc
      241 tacagtatgg gtggaggttg gtttggggaa ggcatcctca ctggcaatga gaaggagacc
      301 atgcagtccc ttaatgaccg cctggccagc tacctggaga aggtgcgtca gttggaacag
      361 gagaatgcta gcctggagag ccgaattcgg gagtggtgtg agcagcaggt gccatatatg
      421 tgccccgatt accagtccta cttccggacc atggaggagc tccagaagaa gactctttgc
      481 agtaaggcag agaacgccag attggtggtg cagatcgaca atgccaagct ggcggccgat
      541 gacttcagga ccaagtatga gacggaggtt tctctgcggc agctggtgga ggctgacatc
      601 aacggcctgc gcaggatcct ggatgatctg actctgtgca aggctgacct ggaagctcag
      661 gtggagtccc tgaaggaaga attgctctgc cttaagaaga accatgagga ggaggtgaat
      721 tcgctgcgct gccagctggg cgatcgtctc aacgtcgagg tggacgctgc tccacccgtt
      781 gatctgaacc gtgttctgga tgagatgagg tgccagtatg agaccttggt ggagaataac
      841 cggagggacg cagaagactg gtatgacacc cagactgagg aactgaacca gcaggtcgtg
      901 accagctcag agcagctgca gtcctgccag tcggacatca ttgagctgag acgcactgtc
      961 aactccctgg agatagagct gcaggcccag cagagcatga gagacgcttt ggactccacc
     1021 ctggccgaga cagaagcccg ctacagctct cagctggccc agatgcagtg cctgattggc
     1081 agtgtggagt ctcagcttgg tgagatccgg gctgacctgg agcgtcagaa ccaggagtac
     1141 caggtgctgc tggatgtccg ggcccggctg gagtgtgaga tcaatacgta caggggtctc
     1201 ctggagagcg aggacagcaa gcttccctgc aacccatgtg ctcctgacta ctcaccctcc
     1261 aagtcctgtc tcccctgcct tcctgcggtc tcctgcagca cgggtgcagc tcgtacaacc
     1321 tgcagccccc gccctgtctg tgtgccctgc ccagggggcc ggttctga
//
LOCUS       NM_175588               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 7g (Taar7g),
            mRNA.
ACCESSION   NM_175588
VERSION     NM_175588.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380197.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="trace amine-associated receptor 7g"
                     /db_xref="GeneID:294131"
                     /db_xref="RGD:631388"
     CDS             1..1077
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="taR-9; taR-7g; trace amine receptor 7g; trace amine
                     receptor 9"
                     /codon_start=1
                     /product="trace amine-associated receptor 7g"
                     /protein_id="NP_783178.1"
                     /db_xref="GeneID:294131"
                     /db_xref="RGD:631388"
                     /translation="MATDDGSFPWTQESILSRDLLSALSPQLCYENLNRSCVRSPYSP
                     GSRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADLLVGLTVMP
                     FSMVRSVEGCWYFGDSYCKLHSCFDISFCSSSLLHLCFISVDRHIAVSDPLIYPTRFT
                     ASVSGKYITFSWLLSIIYGFSLIYTGASEAGLEDLVSALTCVGGCQVAVNQSWVFINF
                     LLFLVPALVMMTVYSKIFLIAKQQAQNMEKMSKQTARASDSYKDRVAKRERKAAKTLG
                     IAVAAFLLSWLPYFVDSIIDAFLGFITPTYVYEILAWIAYYNSAMNPLIYAFFYPWFR
                     KAIKLIVTGKILKENSSTINLFPE"
     misc_feature    100..102
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y1.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    148..222
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..312
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    361..429
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    370..429
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    496..546
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    499..561
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..699
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..630
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y1.1); glycosylation site"
     misc_feature    637..699
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    814..882
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    823..885
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    913..990
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    928..999
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y1.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7g"
                     /gene_synonym="Ta9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctacag atgatggcag ttttccctgg actcaggaaa gcatcctgag cagagatctg
       61 ctctcagcct tgtctcccca gctgtgctat gagaacctga acagatcctg tgtcaggagc
      121 ccatactccc caggctctcg cctcatcctc tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tgttggtggg tctgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttgggga cagttactgt
      361 aaattacaca gttgttttga tatttctttc tgtagttctt ctctcttaca cttgtgcttc
      421 atctctgttg atagacatat tgcagtcagt gaccccctga tttaccccac caggttcact
      481 gcatctgttt ctggcaagta catcaccttc tcctggctcc tgtccatcat ctatggcttt
      541 tccctcattt acacaggagc aagtgaagct gggctggagg atctagtgag tgcccttact
      601 tgtgtgggcg gctgtcaagt tgcagtgaat caaagctggg tcttcatcaa tttcctatta
      661 tttcttgtcc ctgcccttgt gatgatgact gtctactcta agatcttcct cattgcaaag
      721 cagcaggctc agaacatgga gaagatgagc aagcagactg ccagggcatc tgacagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccttgggcat tgcagtggct
      841 gccttcctcc tttcatggct gccatacttc gttgattcca tcattgatgc cttcctgggt
      901 ttcattacgc ccacgtatgt gtatgaaatc ctagcttgga tagcttacta taactcggcc
      961 atgaaccctt tgatttatgc tttcttctat ccttggtttc gaaaagccat caaactcatt
     1021 gtcactggca aaatcttgaa agagaattcc tcaaccatca atttgttccc tgagtag
//
LOCUS       NM_001166680             924 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 106 (Tas2r106),
            mRNA.
ACCESSION   NM_001166680
VERSION     NM_001166680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362739.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..924
                     /gene="Tas2r106"
                     /note="taste receptor, type 2, member 106"
                     /db_xref="GeneID:100310878"
                     /db_xref="RGD:2314260"
     CDS             1..924
                     /gene="Tas2r106"
                     /note="T2R19; T2R106; taste receptor type 2 member 19"
                     /codon_start=1
                     /product="taste receptor type 2 member 106"
                     /protein_id="NP_001160152.1"
                     /db_xref="GeneID:100310878"
                     /db_xref="RGD:2314260"
                     /translation="MLTIPEGILLCFITSGSVLGVLGNGFILHVNCTDCVRQKFSTTG
                     FIFTGLAISRICVICIIISDGYLKLFSPHMVASDAHIIGISYLWIITNHTSTCFATIL
                     NLFYFLKIANFSHYIFFCLKRKLNTIFIFLLGCLFISWSVAFPQTVKIFNDKMKHRNT
                     SWKFHLHKSKFIINHILLNLGVIFFCMVAIITSFLLIISLWKHNRKMQLYVSRFKSLN
                     TEVHLKVMKVLISFIILLILHVIGILIETLSFLRYENKLLLILGLNFSSMYPCCHSFI
                     LILANNQLKQASLKALKQFKCHKKDKDVRET"
     misc_feature    19..867
                     /gene="Tas2r106"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    19..867
                     /gene="Tas2r106"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..84
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    25..99
                     /gene="Tas2r106"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    25..99
                     /gene="Tas2r106"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    124..186
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    130..195
                     /gene="Tas2r106"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    130..195
                     /gene="Tas2r106"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Tas2r106"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Tas2r106"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    373..435
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    391..441
                     /gene="Tas2r106"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    391..441
                     /gene="Tas2r106"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    475..477
                     /gene="Tas2r106"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET1.1); glycosylation site"
     misc_feature    511..582
                     /gene="Tas2r106"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    511..582
                     /gene="Tas2r106"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    538..600
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    664..732
                     /gene="Tas2r106"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    664..732
                     /gene="Tas2r106"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    682..744
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     misc_feature    766..843
                     /gene="Tas2r106"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    766..843
                     /gene="Tas2r106"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    772..834
                     /gene="Tas2r106"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET1.1);
                     transmembrane region"
     exon            1..924
                     /gene="Tas2r106"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgacta taccagaagg catcctcctt tgctttataa ctagtggttc agtactggga
       61 gttctaggga atgggtttat cctgcatgtg aactgcactg actgtgtcag gcagaagttc
      121 tccacgactg gctttatttt cacgggcttg gctatttcca gaatctgtgt catatgtata
      181 ataatctctg atggatattt aaaattattt tctccacata tggttgcctc cgatgcccac
      241 attataggga tttcttacct gtggataatc accaatcaca caagtacatg ttttgccacc
      301 atcctcaacc tcttctattt cctgaagata gcaaattttt ctcactacat cttcttctgc
      361 ttgaagagaa aactcaatac aatatttatc tttctcctgg gatgcttatt tatatcatgg
      421 tcagttgctt ttccacaaac agtgaagata tttaatgata aaatgaagca cagaaatact
      481 tcctggaagt ttcacctcca taagagtaag ttcattataa accacattct tctcaacctt
      541 ggagtcatat tcttctgtat ggtggccatc attacatcct tcctattaat tatttcactt
      601 tggaaacaca acaggaagat gcagttgtat gtctcgagat tcaaaagcct taacacagaa
      661 gttcatttga aagtcatgaa agttttaatt tcttttatta tcctgttaat attgcacgtc
      721 ataggtattc tgatagaaac attgagcttt ctccgatatg aaaataaact tctacttatt
      781 ttgggtttga acttttcaag catgtatcct tgctgtcatt catttatcct aattctagca
      841 aacaaccagc tgaagcaggc ttctttgaaa gcactgaagc aatttaaatg ccataagaaa
      901 gacaaggatg tcagagagac atga
//
LOCUS       NM_001025061             885 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 143 (Tas2r143),
            mRNA.
ACCESSION   NM_001025061 XM_578254
VERSION     NM_001025061.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 885)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362747.1.
            
            On Jun 25, 2005 this sequence version replaced XM_578254.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..885
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="taste receptor, type 2, member 143"
                     /db_xref="GeneID:502756"
                     /db_xref="RGD:1566290"
     CDS             1..885
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="T2R27; T2R143; taste receptor type 2 member 27"
                     /codon_start=1
                     /product="taste receptor type 2 member 143"
                     /protein_id="NP_001020232.1"
                     /db_xref="GeneID:502756"
                     /db_xref="RGD:1566290"
                     /translation="MPSTPTLIFIVIFFLVSVASMLQNGFMIIVLGREWMRNRALPAV
                     DMIVASLASSRFCLHGIAILNNFLASFDFCYQANFVGILWDFINTLILWLTAWLAIFY
                     CVKISSFSHPVLFWLKWRISQLVPRLLLVSLIMGGLSAIISATGNIIANQMIISQGFH
                     GNCTFGHMSLDFYRYYYLSHAVLMWFTPFFLFLVSIIFLMFSLYRHVEKMRGHRPGPW
                     DPRTQAHTMALKSLTVFITFYILFFLALIISSTKSKTMHSYWYWVREIIIYTGIFLNS
                     IILVLSNPKLRKALKMRF"
     misc_feature    19..873
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="mammalian taste receptor 2, subtype 16, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R16; cd15017"
                     /db_xref="CDD:320145"
     misc_feature    19..873
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="mammalian taste receptor 2, subtype 16, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R16; cd15017"
                     /db_xref="CDD:320145"
     misc_feature    22..99
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320145"
     misc_feature    22..99
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320145"
     misc_feature    22..84
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    130..192
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320145"
     misc_feature    133..207
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320145"
     misc_feature    232..300
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320145"
     misc_feature    232..300
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320145"
     misc_feature    241..303
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    379..429
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320145"
     misc_feature    379..429
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320145"
     misc_feature    385..447
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    484..486
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES3.1); glycosylation site"
     misc_feature    520..591
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320145"
     misc_feature    520..591
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320145"
     misc_feature    541..603
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    664..741
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320145"
     misc_feature    664..741
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320145"
     misc_feature    682..744
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     misc_feature    772..849
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320145"
     misc_feature    772..849
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320145"
     misc_feature    781..843
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES3.1);
                     transmembrane region"
     exon            1..885
                     /gene="Tas2r143"
                     /gene_synonym="RGD1566290"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccctcca cacccacatt gatcttcatt gtcatctttt ttctggtatc agtggcctct
       61 atgttgcaga atggcttcat gatcattgtg ctgggcagag agtggatgag gaaccgggca
      121 ctgccggcag ttgacatgat tgtggcttct cttgcttcct cccggttctg cctacatggg
      181 atagccatcc tcaacaattt cttggcctcc tttgattttt gttaccaagc aaactttgtt
      241 ggcatcctct gggacttcat taatactctc attttgtggc ttactgcctg gcttgccatc
      301 ttctactgtg tgaagatctc ctctttctcc caccctgtcc tcttttggct caagtggagg
      361 atttcccagt tagttcccag gctgctgctg gtatctctca tcatgggtgg cctgtcagcc
      421 atcatatcag ctaccgggaa catcattgcc aatcagatga tcatctccca aggtttccat
      481 ggaaactgca cttttggtca catgtcactg gacttctatc ggtattatta cctgtctcac
      541 gcagtgctca tgtggttcac tcctttcttc ctgtttctag tgtccattat cttcctcatg
      601 ttctcactgt accggcatgt ggagaagatg aggggccata ggcctgggcc ttgggatccc
      661 cgtacacagg cacacaccat ggctctgaaa tcccttactg tcttcatcac cttctatata
      721 ttattttttc tggccctgat aatttctagt acaaaaagta aaactatgca cagttactgg
      781 tattgggtcc gagaaattat catctacact ggcatctttt tgaactccat catcttggtg
      841 cttagcaacc ccaagctgag aaaggccctg aagatgagat tttag
//
LOCUS       NM_020090               3550 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 24 member 1 (Slc24a1),
            mRNA.
ACCESSION   NM_020090 XM_346825
VERSION     NM_020090.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Jalloul,A.H., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Cation dependencies and turnover rates of the human K-dependent
            Na-Ca(2) exchangers NCKX1, NCKX2, NCKX3 and NCKX4
  JOURNAL   Cell Calcium 59 (1), 1-11 (2016)
   PUBMED   26631410
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Zheng,M., Gong,Y., Wang,X., Xie,Q., Tang,H., Wang,D. and Chen,X.
  TITLE     Alteration of intracellular calcium and its modulator SLC24A6 after
            experimental intracerebral hemorrhage
  JOURNAL   Acta Neurochir Suppl 118, 169-173 (2013)
   PUBMED   23564126
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Lytton,J.
  TITLE     Na+/Ca2+ exchangers: three mammalian gene families control Ca2+
            transport
  JOURNAL   Biochem J 406 (3), 365-382 (2007)
   PUBMED   17716241
  REMARK    Review article
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Altimimi,H.F. and Schnetkamp,P.P.
  TITLE     Na+/Ca2+-K+ exchangers (NCKX): functional properties and
            physiological roles
  JOURNAL   Channels (Austin) 1 (2), 62-69 (2007)
   PUBMED   18690016
  REMARK    Review article
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Li,X.F. and Lytton,J.
  TITLE     Differential expression of Na/Ca exchanger and Na/Ca + K exchanger
            transcripts in rat brain
  JOURNAL   Ann N Y Acad Sci 976, 64-66 (2002)
   PUBMED   12502535
  REMARK    GeneRIF: Differential expression in the rat brain
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Poon,S., Leach,S., Li,X.F., Tucker,J.E., Schnetkamp,P.P. and
            Lytton,J.
  TITLE     Alternatively spliced isoforms of the rat eye
            sodium/calcium+potassium exchanger NCKX1
  JOURNAL   Am J Physiol Cell Physiol 278 (4), C651-C660 (2000)
   PUBMED   10751314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF176688.1.
            
            On May 4, 2006 this sequence version replaced XM_346825.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="solute carrier family 24 member 1"
                     /db_xref="GeneID:56814"
                     /db_xref="RGD:620080"
     exon            1..1795
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="retinal rod Na-Ca+K exchanger;
                     Na(+)/K(+)/Ca(2+)-exchange protein 1;
                     sodium/calcium/potassium exchanger; solute carrier family
                     24 (sodium/potassium/calcium exchanger), member 1; retinal
                     Na/Ca,K exchanger"
                     /codon_start=1
                     /product="sodium/potassium/calcium exchanger 1"
                     /protein_id="NP_064475.1"
                     /db_xref="GeneID:56814"
                     /db_xref="RGD:620080"
                     /translation="MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRP
                     QNPPSMWTKVSSQQPIKLAIRDLPNDEITVTDKDPPEASSEVEGEMLAPQDTVIIGEA
                     APSIAMEDTPNPPITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGR
                     QRVKSYTPKPRGGRKSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRML
                     EPRSERTAGKTSLKRMVPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTP
                     LRAVLQPTPATSEEQVTASIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDR
                     EKRPSTAHGTLVTPQVKAVLTTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPS
                     ALPPGWPNLHPKAEYPPDLFSVEDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGV
                     ITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIG
                     TCALFSREILNLTWWPLFRDVSFYILDLSMLIVFFLDSLIAWWESLLLLLAYALYVFT
                     MKWNKQIERWVKEQLSRRPVAKVMALGDLSKPSDGAIEENEQQDNKKLKLPSVLTRGS
                     SSASLHNSIIRSTIYHLMLHSLDPLGEARPSKDKQESLNQEARVLPQTKAESSSDEEE
                     PAELPAVTVTPAPAPEDKGDQEEDPGCQEDVDEAEHRGDMTGEEGERETEAEGKKDEE
                     GETEAERKEDGQEEETETKGKEKQEGETESEGKDEQEGETEAEGKEADHEGETEAEGK
                     EVEHEGETEAEGTEDEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEAERKETNHEG
                     ETEAEGKEADHEGETEAEGNVEHQGETEAEGKVEHEGETEAGEKDEHEGQSETQADDT
                     EVKDGEGEAEANAEDQCETAQGEKGADGGGGSDGGDSEEEEDEEDEEEEEEEEEEEEE
                     EESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQEARKFFVITFLGSIIWI
                     AMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSS
                     VGSNIFDITVGLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLMLLFVIFSIASCKW
                     RMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV"
     misc_feature    5..3547
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    5..3547
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    323..700
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    767..832
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    815..817
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZM6.1); glycosylation site"
     misc_feature    902..973
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1262..1324
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    1385..1507
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Alpha-1"
     misc_feature    1397..1459
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    1478..1540
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    1562..1636
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    1661..1711
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    1796..1855
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1877..1879
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="Phosphoserine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9QZM6.1); phosphorylation
                     site"
     misc_feature    1952..2953
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2072..2074
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O60721; propagated from
                     UniProtKB/Swiss-Prot (Q9QZM6.1); phosphorylation site"
     misc_feature    2192..2719
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: 14 X approximate tandem repeats"
     misc_feature    2972..3034
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    3056..3118
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    3164..3226
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    3185..3280
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     Region: Alpha-2"
     misc_feature    3281..3343
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    3368..3430
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     misc_feature    3455..3517
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZM6.1);
                     transmembrane region"
     exon            1796..1849
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1958
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2042
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2134
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..3043
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3133
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3300
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3550
                     /gene="Slc24a1"
                     /gene_synonym="Nckx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccatgggg aaattgatca ggatggggac gcaggagagg cggttactcc gaccaaagag
       61 gcttcattgg agtcgcctcc ttttcttcct gggaatgttg atcattggtt ccacttatca
      121 gcacctgagg agaccccaga atcccccttc aatgtggaca aaagtctcct cacagcagcc
      181 tattaaactg gccatcaggg acctccccaa tgatgagata acagtgacag acaaagaccc
      241 tccagaggct agctctgaag tggagggtga gatgctagca ccccaagaca cagtgatcat
      301 aggtgaagca gcacctagca tagcaatgga ggacaccccc aatccaccca taacaaccaa
      361 gatcactcca acgtcactaa agaacaatta tagccccaca acagctggca cgaggagaca
      421 aaaagaaaac attccaccca cacctagcag agcaccgagt cacttcatct caacttcagg
      481 cagacagaga gtgaaaagct ataccccaaa acccagggga ggaaggaaga gctccagccc
      541 aactcacacc agggaagaag gaaggatgca taccccatcc ccagcaggtg cgccccgcac
      601 catcagcccc acatcaacag agaaagacag tgaaaccacg gcaacctata ggatgttgga
      661 gcccagatct gagagaacag caggaaaaac ttctctcaag agaatggttc cgaacacccg
      721 gactttctta acacgcgaag tagaaacaga cctcgtgact tctccaagtt tggtggggaa
      781 gaacaccctg ggaagtccta gaagaggaga aagaaacagc tctaccactc ccctgcgagc
      841 agtcctgcag cctacccctg ccacctctga ggagcaagtg acggcaagca tcaggatggg
      901 tagcacccca gcaaccactg aaggttctac tgctgcccag agaattggca atcccttgtc
      961 cggaactagt acaccagctg ttagaattgc ctcagtcacg gacagggaaa agagaccttc
     1021 cacagcacac ggcaccctag taactcccca agtcaaggca gtcctgacca cacaggtcca
     1081 ccgctgtgtg gttgtgaagc cagccccagc tgtacccatg accccatctc cgagcatgac
     1141 agccatcctg ttcccagagg cacctacttc cggtccctca gccttgccgc ctggctggcc
     1201 aaacctccac cccaaggcgg agtatccccc agacctgttc agtgtggagg atcgacgcca
     1261 gggctgggtg gtcctacaca tcttcggtat gacgtacgtg tttgtggcct tggccatcgt
     1321 gtgtgatgag tactttgtcc cagccctggg ggtcatcacg gacaagcttc agatctccga
     1381 ggatgtggcc ggggccacat tcatggctgc cggaggctca gcccctgagc tcttcacctc
     1441 tctcattggt gtctttatct cccatagcaa tgtgggtatt ggtaccatcg tgggctctgc
     1501 tgtgttcaac atcctttttg tcatcggcac ctgcgccctc ttctcccggg agatcctcaa
     1561 cctcacctgg tggcccctgt tccgagatgt ctccttctac atccttgact tgtctatgct
     1621 catagtcttt ttcctggata gtctcattgc ctggtgggag agcctgctgc tgctgctggc
     1681 ctacgctctc tatgtgttca ccatgaagtg gaacaagcag attgaacgct gggtgaaaga
     1741 gcagcttagc aggaggccag tagccaaagt catggctcta ggagacctca gcaagcccag
     1801 tgatggtgcc attgaggaaa atgaacaaca ggataacaag aagctgaagc tcccgtctgt
     1861 gctgacccga gggagcagct cggcctccct gcacaacagc atcatccgca gcaccatcta
     1921 ccacctcatg ctccacagct tggaccccct gggggaagcc cgcccctcca aggacaagca
     1981 ggaaagtttg aatcaggaag ccagagtcct cccccagacc aaagcagaaa gcagctcaga
     2041 cgaggaggag ccagccgagc tccctgcggt cacggtcact ccagcccctg ctccagagga
     2101 caagggagat caggaggagg atccaggctg ccaggaagat gtggatgagg ctgaacacag
     2161 aggagacatg acaggtgaag agggtgaaag ggaaaccgag gcagaaggaa aaaaagatga
     2221 agaaggggaa actgaggcag aaaggaaaga agatggtcaa gaagaagaaa ctgagacaaa
     2281 agggaaagag aaacaagaag gggaaactga gtcagaagga aaagatgaac aagaagggga
     2341 aactgaggca gaaggaaaag aagctgacca tgaaggggaa actgaggcag aaggaaaaga
     2401 ggttgaacat gaaggggaaa ctgaagcaga aggaacagaa gatgaacaag aaggggaaac
     2461 tgaggcagaa ggaaaagaag ttgaacaaga aggggaaact gaggcagaag gaaaagaagt
     2521 tgaacatgaa gtggaaactg aggcagaaag aaaagaaact aaccatgaag gggaaactga
     2581 ggcagaagga aaagaagctg accatgaagg ggaaacagag gcagaaggaa atgttgaaca
     2641 tcaaggggaa actgaggcag aaggaaaagt tgaacatgag ggggaaaccg aggcaggaga
     2701 aaaagatgag catgaagggc aaagtgagac ccaagcagac gacactgagg tgaaagatgg
     2761 tgagggtgaa gcagaagcca atgctgaaga tcaatgtgag accgcccaag gtgagaaagg
     2821 tgcagacggt ggagggggaa gtgatggagg ggacagtgaa gaagaggagg atgaagagga
     2881 tgaagaggag gaggaagagg aggaagagga ggaagaggag gaggaaagtg aggagcctct
     2941 gtccttggaa tggcctgaga gcaggcagaa gcaggctatc tacctctttc tcctgcccat
     3001 cgtgttccca ctgtggctga caatacctga tgtacggagg caggaggcca ggaagttttt
     3061 tgtcatcacc ttcctgggat ccatcatctg gatagccatg ttctcatacc tcatggtgtg
     3121 gtgggctcac caggttggtg aaaccattgg gatttctgaa gagattatgg gtttgacgat
     3181 cctagcggca ggcacttcaa ttcctgacct catcaccagt gtgatcgttg cccggaaagg
     3241 cctgggagac atggccgtgt caagctcggt gggcagtaac atatttgata tcacagtggg
     3301 cctgcctgtc ccctggctcc tgttctccct catcaatgcg ctgcagccta tccctgtcag
     3361 cagcaacggc ctgttctgtg ccattgtctt gctgtttctc atgctcctgt ttgtgatctt
     3421 ctcaatcgct tcgtgtaaat ggagaatgaa caagatcctg ggcttcacca tgttccttct
     3481 ctactttgtg ttcctggtga tcagtgtgat gttagaagat cgcatcatat cctgccctgt
     3541 atctgtctga
//
LOCUS       NM_001110144             663 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus claudin 24 (Cldn24), mRNA.
ACCESSION   NM_001110144 XM_001059310 XM_577519
VERSION     NM_001110144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 663)
  AUTHORS   Mineta,K., Yamamoto,Y., Yamazaki,Y., Tanaka,H., Tada,Y., Saito,K.,
            Tamura,A., Igarashi,M., Endo,T., Takeuchi,K. and Tsukita,S.
  TITLE     Predicted expansion of the claudin multigene family
  JOURNAL   FEBS Lett 585 (4), 606-612 (2011)
   PUBMED   21276448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473995.2.
            
            On or before Oct 26, 2007 this sequence version replaced
            XM_577519.1, XM_001059310.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..663
                     /gene="Cldn24"
                     /gene_synonym="RGD1562043"
                     /note="claudin 24"
                     /db_xref="GeneID:502083"
                     /db_xref="RGD:1562043"
     CDS             1..663
                     /gene="Cldn24"
                     /gene_synonym="RGD1562043"
                     /note="claudin 22 like"
                     /codon_start=1
                     /product="putative claudin-24"
                     /protein_id="NP_001103614.1"
                     /db_xref="GeneID:502083"
                     /db_xref="RGD:1562043"
                     /translation="MAFIFKTAMQSVALSLSLLGWVLAITTTYLPHWKNLNLELNEME
                     NWTMGLWKSCVIQEEVGRQCKDFDSFLALPAELQISRILMSLSNGLGLLGLLASGCGL
                     DCLRLGETRKGLKRRLLILGGTLLWTSGVMVLVPVSWVAHMTVQEFWDETVPEIVPRW
                     EFGEALFLGWFAGLCLVLGGCVLHCAACWRPAPPASGHYAVAGLGDHSSYLENGTAQP
                     KV"
     misc_feature    19..540
                     /gene="Cldn24"
                     /gene_synonym="RGD1562043"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    19..540
                     /gene="Cldn24"
                     /gene_synonym="RGD1562043"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     exon            1..663
                     /gene="Cldn24"
                     /gene_synonym="RGD1562043"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctttca tcttcaaaac ggccatgcaa tcggtcgcgc tttctctgtc attgctggga
       61 tgggttctag ccattactac cacgtatctg ccacactgga agaacctcaa cctggagctg
      121 aacgagatgg aaaactggac catggggctc tggaaatcct gcgtcatcca ggaggaggtc
      181 gggaggcaat gcaaggactt tgactccttc ctggccttgc cagctgaact gcagatctcc
      241 aggatcctga tgtccctgtc caatgggctg gggctgctgg gcttgctggc ctctggctgt
      301 ggcctggact gtctgaggct cggagagacc cggaagggtc tgaagaggcg actgctcatc
      361 ctgggaggga ccctgctctg gacctctggt gtgatggtcc tggttcctgt ctcctgggtg
      421 gcccacatga cagtgcaaga gttctgggat gagactgtac ctgagattgt gcccaggtgg
      481 gagttcgggg aggccctgtt cctgggctgg tttgctggtc tctgcctggt gcttggagga
      541 tgtgtgcttc actgtgcagc ctgctggagg ccggctcctc cagcctcggg ccactatgca
      601 gtggcgggac ttggagacca cagttcatac ctggaaaatg gaactgcaca gcctaaagtg
      661 taa
//
LOCUS       NM_001013915             990 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 134 (Tas2r134),
            mRNA.
ACCESSION   NM_001013915 XM_003753722 XM_008775377 XM_229912
VERSION     NM_001013915.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Wu,S.V., Chen,M.C. and Rozengurt,E.
  TITLE     Genomic organization, expression, and function of bitter taste
            receptors (T2R) in mouse and rat
  JOURNAL   Physiol Genomics 22 (2), 139-149 (2005)
   PUBMED   15886333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362743.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008775377.1, XM_003753722.1, XM_229912.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..990
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="taste receptor, type 2, member 134"
                     /db_xref="GeneID:295589"
                     /db_xref="RGD:1359393"
     CDS             1..990
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="taste receptor type 2 member 23"
                     /codon_start=1
                     /product="taste receptor type 2 member 134"
                     /protein_id="NP_001013937.1"
                     /db_xref="GeneID:295589"
                     /db_xref="RGD:1359393"
                     /translation="MRCSLRGCVQGRGGKSGVSLSKFSPKKMSFFFIFMVIFCIQSLV
                     ALLQNGFLATVLGREWVRSQGLPAGDMIVACLAASRFCLHGVAIVNNFLTFVKLWSQK
                     IYFSVLWDFVNTVNFWCTTWLAIFYCVKISSFSHPIFFWIKWRISRSVPRLLLGSLVI
                     GGLSAVSSATGNTIAFQMTACENYTLAYRTRAFYAYYFRCHAMLMWIIPFFLFLLSVI
                     LLMFSLYRHLEHMRYRRPWSHDYSTQAHTMALKSLAFFLVFYTSYVLFLVISVTRVVN
                     VHSSWHWAWEVITYMGILLHSTILTLSNPKMRKALKIKFPDLCVARSQDKRRG"
     misc_feature    82..144
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    94..936
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="mammalian taste receptor 2, subtype 16, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R16; cd15017"
                     /db_xref="CDD:320145"
     misc_feature    94..936
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="mammalian taste receptor 2, subtype 16, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R16; cd15017"
                     /db_xref="CDD:320145"
     misc_feature    97..174
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320145"
     misc_feature    97..174
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320145"
     misc_feature    205..267
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    208..282
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320145"
     misc_feature    208..282
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320145"
     misc_feature    307..375
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320145"
     misc_feature    307..375
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320145"
     misc_feature    364..426
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    454..504
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320145"
     misc_feature    454..504
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320145"
     misc_feature    460..522
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    547..549
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES7.1); glycosylation site"
     misc_feature    583..654
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320145"
     misc_feature    583..654
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320145"
     misc_feature    604..666
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    727..804
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320145"
     misc_feature    727..804
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320145"
     misc_feature    754..816
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     misc_feature    835..912
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320145"
     misc_feature    835..912
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320145"
     misc_feature    847..909
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES7.1);
                     transmembrane region"
     exon            1..990
                     /gene="Tas2r134"
                     /gene_synonym="GPCR; T2R134; T2R23; T2R34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgctgct ctctccgtgg atgtgtccaa ggacgtggcg gtaagagtgg agtcagtcta
       61 agtaaattct ccccaaagaa gatgtctttc ttcttcatct tcatggtcat cttttgtata
      121 cagtctctag ttgctttgct gcaaaatggc ttcttggcca ctgtgctggg cagggaatgg
      181 gtacgaagcc agggactccc tgcaggtgac atgattgtgg cttgcctagc tgcctccagg
      241 ttctgcctgc atggagtagc catcgtaaac aacttcctga cctttgttaa gctatggagc
      301 caaaagatct atttttctgt cctctgggac ttcgtcaaca ctgtcaattt ctggtgtacc
      361 acctggcttg ccatcttcta ctgcgtaaag atctcttcgt tctcccaccc catcttcttc
      421 tggataaaat ggagaatttc tcggtctgtg cccaggttac tgctgggatc cctggtcatt
      481 ggtggactgt cggccgtctc ctccgccact ggaaacacaa tcgcctttca gatgaccgcc
      541 tgtgagaact acacgcttgc ttatagaacg agagccttct acgcgtatta ttttcgctgt
      601 catgcaatgc tgatgtggat catcccgttc ttcctcttcc tgctgtccgt tatcttgctc
      661 atgttctcac tctaccggca tctggaacac atgaggtacc gcagaccctg gtctcacgat
      721 tacagcaccc aggcccacac tatggctctg aagtcgctgg ccttcttcct cgtcttctat
      781 acatcgtatg tcctgttcct tgtgatatct gttacacgag tcgtgaatgt ccacagttcc
      841 tggcactggg cctgggaagt gataacctac atgggcatcc tactgcattc caccattctg
      901 acactaagca accccaagat gagaaaggcc ctcaagataa agttcccaga cctttgtgtt
      961 gccagatcac aagacaagag gcgtggttaa
//
LOCUS       NM_001108962             932 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus R3H domain containing-like (R3hdml), mRNA.
ACCESSION   NM_001108962 XM_001070429
VERSION     NM_001108962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 932)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001070429.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16418971
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..932
                     /gene="R3hdml"
                     /note="R3H domain containing-like"
                     /db_xref="GeneID:366245"
                     /db_xref="RGD:1305296"
     exon            1..431
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    135..137
                     /gene="R3hdml"
                     /note="upstream in-frame stop codon"
     CDS             171..932
                     /gene="R3hdml"
                     /note="peptidase inhibitor R3HDML; R3H domain (binds
                     single-stranded nucleic acids) containing-like"
                     /codon_start=1
                     /product="peptidase inhibitor R3HDML precursor"
                     /protein_id="NP_001102432.1"
                     /db_xref="GeneID:366245"
                     /db_xref="RGD:1305296"
                     /translation="MPLLYSIVGLAGLLLWMGHTVGALRMPNTTLVQGRPKNIAVWPL
                     SGLGVPRHRRKRHISARDMNALLDYHNHIRASVHPPASNMEYMVWDEQLARAAEAWAT
                     QCIWAHGPSQLTKYVGQNLSVHSGRYRSVVDLVKSWSEEKRHYSFPAPKDCTPHCPWL
                     CSGPVCSHYTQMVWASSSRLGCAIHTCSSINVWGSTWQQAVYLVCNYAIKGNWIGEAP
                     YKTGKPCSACPPSYQGNCNSNMCFSGLKSNRLPWV"
     sig_peptide     171..239
                     /gene="R3hdml"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    357..794
                     /gene="R3hdml"
                     /note="CAP (cysteine-rich secretory proteins, antigen 5,
                     and pathogenesis-related 1 proteins) domain of peptidase
                     inhibitor R3HDML; Region: CAP_R3HDML; cd18815"
                     /db_xref="CDD:349409"
     misc_feature    357..794
                     /gene="R3hdml"
                     /note="CAP (cysteine-rich secretory proteins, antigen 5,
                     and pathogenesis-related 1 proteins) domain of peptidase
                     inhibitor R3HDML; Region: CAP_R3HDML; cd18815"
                     /db_xref="CDD:349409"
     exon            432..550
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            551..683
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            684..799
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            800..932
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtattgag tatcgggaag agagctgggt cagaggatct ctgccaagtt cccaaggagc
       61 atcctccgga ctggcagtgc tcaaggagag ttctcagggt ttggcgttct cacacctctt
      121 ctaggcagca gctctgactg caccagacag gtacaccatc ccagacaggt atgcctcttc
      181 tgtacagcat cgtgggcctt gcgggccttc tcctgtggat gggtcacaca gtgggggcct
      241 taaggatgcc caacaccaca ctggtccagg gccgacccaa gaacatagct gtgtggcccc
      301 tgtctggcct gggggtgccc cggcaccgcc ggaagcgtca catctctgcc agggatatga
      361 acgccttgct ggattatcac aaccacatcc gggccagcgt acaccctcct gcttccaaca
      421 tggagtatat ggtttgggat gagcagctgg ccagggctgc tgaagcctgg gccacccaat
      481 gcatctgggc ccacggaccc tcacagctga cgaagtacgt gggccagaat ctctctgtcc
      541 actccggccg gtaccgttcc gtggtagatc ttgtgaagtc ttggtctgag gaaaagcgcc
      601 attactcatt cccagctcca aaggattgca ccccacactg cccttggctg tgcagcggtc
      661 ctgtgtgctc ccactatacc cagatggtgt gggcctcctc cagtcggctg ggatgcgcta
      721 ttcacacgtg cagcagcatc aatgtgtggg gcagcacctg gcagcaggct gtgtacctgg
      781 tctgcaacta cgccattaag ggcaactgga ttggggaggc accttacaag actgggaagc
      841 catgttctgc ctgccctccc agttaccaag gcaactgcaa cagcaacatg tgcttctctg
      901 ggctcaaatc caacaggctc ccatgggtct ga
//
LOCUS       NM_001166678             993 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 136 (Tas2r136),
            mRNA.
ACCESSION   NM_001166678
VERSION     NM_001166678.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 993)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   2  (bases 1 to 993)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..993
                     /gene="Tas2r136"
                     /note="taste receptor, type 2, member 136"
                     /db_xref="GeneID:100310876"
                     /db_xref="RGD:2314262"
     CDS             1..993
                     /gene="Tas2r136"
                     /note="T2R40; T2R136; taste receptor type 2 member 40"
                     /codon_start=1
                     /product="taste receptor type 2 member 136"
                     /protein_id="NP_001160150.1"
                     /db_xref="GeneID:100310876"
                     /db_xref="RGD:2314262"
                     /translation="MKSQPVTQELHFIFPLFKTISSDIMSFLVSIAGIAMLAQIVLGT
                     FANVFIVLVTCTDCIRRRKLFLADGILTSLAFCRIGMLWVILISWCSIVFHQALSLQV
                     RFSICVGWAVTNHFNMWLATILSILYLLKIGNFSNLIFLGLKRKIKSVFIVVLLASLV
                     LLFPNLITVTVCETVQANGYRGNLTGKTKRTYFMNLTAMISFTLDNIISFTISMVCFL
                     LLIYSLCKHLRTMRLYGKGPHNPSASAHIKALQAVISFLLLFSMFILSLIISGYNYMK
                     PLNEPVHLICQLIGTLYPSSHSYVLLWGNRRIKLAFVLAMVQVRARLWLKEEKP"
     misc_feature    76..948
                     /gene="Tas2r136"
                     /note="mammalian taste receptor 2, subtype 43, and related
                     proteins, member of the seven-transmembrane G
                     protein-coupled receptor superfamily; Region:
                     7tm_TAS2R43-like; cd15027"
                     /db_xref="CDD:320155"
     misc_feature    76..948
                     /gene="Tas2r136"
                     /note="mammalian taste receptor 2, subtype 43, and related
                     proteins, member of the seven-transmembrane G
                     protein-coupled receptor superfamily; Region:
                     7tm_TAS2R43-like; cd15027"
                     /db_xref="CDD:320155"
     misc_feature    91..168
                     /gene="Tas2r136"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320155"
     misc_feature    91..168
                     /gene="Tas2r136"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320155"
     misc_feature    97..159
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    202..276
                     /gene="Tas2r136"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320155"
     misc_feature    202..276
                     /gene="Tas2r136"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320155"
     misc_feature    220..282
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    310..378
                     /gene="Tas2r136"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320155"
     misc_feature    310..378
                     /gene="Tas2r136"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320155"
     misc_feature    367..429
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    448..510
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    457..507
                     /gene="Tas2r136"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320155"
     misc_feature    457..507
                     /gene="Tas2r136"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320155"
     misc_feature    547..549
                     /gene="Tas2r136"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q675B7.1); glycosylation site"
     misc_feature    583..654
                     /gene="Tas2r136"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320155"
     misc_feature    583..654
                     /gene="Tas2r136"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320155"
     misc_feature    583..585
                     /gene="Tas2r136"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q675B7.1); glycosylation site"
     misc_feature    604..666
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    727..804
                     /gene="Tas2r136"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320155"
     misc_feature    727..804
                     /gene="Tas2r136"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320155"
     misc_feature    745..807
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     misc_feature    838..915
                     /gene="Tas2r136"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320155"
     misc_feature    838..915
                     /gene="Tas2r136"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320155"
     misc_feature    850..912
                     /gene="Tas2r136"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B7.1);
                     transmembrane region"
     exon            1..993
                     /gene="Tas2r136"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaatcac aaccagtgac acaagagcta catttcattt ttcctctttt caaaactatt
       61 tcttcagaca taatgagttt cttggtaagc attgcaggca ttgcgatgct ggcacaaatt
      121 gttcttggca cctttgccaa tgtcttcatt gttctggtga cctgcactga ctgcatcagg
      181 agaagaaaat tgttcctggc tgatggaatt ctcacttccc tggccttctg caggattggc
      241 atgctctggg taatattaat aagttggtgc tcaattgtgt ttcaccaagc tttgtcttta
      301 caagtaagat ttagcatttg cgttggctgg gcagtaacca accattttaa tatgtggctt
      361 gccactatac ttagcatact ttatttgttg aagataggta atttctctaa tcttattttt
      421 cttggcctaa agagaaaaat caagagtgtc tttatagttg tacttttggc gagcttggtg
      481 cttttatttc ctaatcttat aacggtaacc gtatgtgaga cagtacaagc gaatggatac
      541 cgaggcaact tgactgggaa gaccaaacgg acttatttca tgaaccttac agctatgata
      601 tcttttactc tagacaacat catttccttc accatatcca tggtctgttt tcttctgtta
      661 atctattccc tgtgtaaaca ccttaggaca atgaggcttt atggaaaagg accccacaac
      721 ccgagtgcgt cagcccacat taaggctctg caagctgtga tctcctttct gttgttattt
      781 tccatgttta ttctgtctct aatcatatca ggttacaatt atatgaagcc tctaaatgaa
      841 ccagtccacc tgatttgcca gcttattggg actttgtatc cttcaagcca ttcttacgtt
      901 ttgctatggg gaaataggag gatcaaactg gcctttgtgt tggctatggt acaggtgagg
      961 gcaaggctct ggctaaaaga agagaaacct tga
//
LOCUS       NM_001011702             585 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Spetex-2E protein (Spetex2e), mRNA.
ACCESSION   NM_001011702 XM_008770590 XM_341287
VERSION     NM_001011702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Iwamoto,Y., Kaneko,T., Ichinose,J., Mori,T., Shibata,Y.,
            Toshimori,K. and Iida,H.
  TITLE     Molecular cloning of rat Spetex2 family genes mapped on chromosome
            15p16, encoding a 23-kilodalton protein associated with the plasma
            membranes of haploid spermatids
  JOURNAL   Biol Reprod 72 (2), 284-292 (2005)
   PUBMED   15371276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB180080.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008770590.1, XM_341287.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..585
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /note="Spetex-2E protein"
                     /db_xref="GeneID:361012"
                     /db_xref="RGD:1359714"
     CDS             1..585
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /note="Spetex-2G protein-like"
                     /codon_start=1
                     /product="Spetex-2E protein"
                     /protein_id="NP_001011702.1"
                     /db_xref="GeneID:361012"
                     /db_xref="RGD:1359714"
                     /translation="MFHQLLKLIQKERGDQGETRPRQKKAGLLSWFIRKASSENFISN
                     HEKRIKKLEELKSEIQKCKIERDELSQILDLYVNDGLNYRLSVELPMLKSQHEMRMMD
                     MHKMTNWISDAMEKYKELTQENNSYRIRNFHLLNERNELKKNIRILMNENRKLLVEQT
                     ELQASCEEGKRLCEEASKTIYTADIESLCPVTFE"
     misc_feature    100..342
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    100..342
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            1..91
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /inference="alignment:Splign:2.1.0"
     exon            92..251
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /inference="alignment:Splign:2.1.0"
     exon            252..383
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /inference="alignment:Splign:2.1.0"
     exon            384..585
                     /gene="Spetex2e"
                     /gene_synonym="Spetex-2E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttcacc agctgctcaa gctcattcag aaggagaggg gagaccaagg agagaccaga
       61 ccgaggcaga agaaagctgg ccttctgtct tggtttattc ggaaggcatc atcagaaaat
      121 ttcatcagta accatgaaaa acgtataaag aaattagagg aactaaaatc tgaaatccag
      181 aagtgtaaaa tcgagcggga tgaactttct caaatcctgg acctttatgt caatgatggt
      241 ttgaactaca ggctgagtgt tgaattgcca atgcttaaat cccaacatga gatgagaatg
      301 atggatatgc ataagatgac caactggata agtgatgcca tggagaagta caaggagctc
      361 acacaagaga acaattccta ccgcatcaga aacttccacc tcctgaatga acgcaatgaa
      421 ttgaagaaga atataaggat tttgatgaat gagaacagaa aactgctggt ggagcagact
      481 gaactgcaag catcctgtga ggagggaaag aggttgtgtg aggaggccag caagaccatc
      541 tacaccgcag atattgaatc cttgtgtcct gttacttttg agtaa
//
LOCUS       NM_001108913            2462 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 32, member A like
            1 (Fam32al1), mRNA.
ACCESSION   NM_001108913 XM_001073383 XM_001080052
VERSION     NM_001108913.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080052.1, XM_001073383.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2462
                     /gene="Fam32al1"
                     /note="family with sequence similarity 32, member A like
                     1"
                     /db_xref="GeneID:365238"
                     /db_xref="RGD:1583796"
     exon            1..2032
                     /gene="Fam32al1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2462
                     /gene="Fam32al1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2100..2102
                     /gene="Fam32al1"
                     /note="upstream in-frame stop codon"
     CDS             2112..2462
                     /gene="Fam32al1"
                     /codon_start=1
                     /product="uncharacterized protein LOC365238"
                     /protein_id="NP_001102383.1"
                     /db_xref="GeneID:365238"
                     /db_xref="RGD:1583796"
                     /translation="MAASTMEAYEQVQKGPLKLKGVAELGVTKRRKKKDKDKAKMLET
                     MGMRKKSEEEKQHCLDKRTPAQAAFEKMQEKRQTERILKKASKTHKQRVEDFNRHLDT
                     LTEHYDIPKVSWTK"
ORIGIN      
        1 ttcttgctta acctggagga aagctggcag cccgcccacc ccggtgaccc cctgtcatcc
       61 ccatcaccct caaccttctt atgtaggagt tagagattca gactcggggt ctcacaccgg
      121 gaagttcacc attacgcttt aaaccatccc tccagctcct ttttggctca gtatgtaatc
      181 ctgacttgct gggaactcat tacaaagccc gataggacct tgaacttgtg gtagtctctg
      241 taatgcctga acacttctgt gattagagtt aatttacagt tatgtgttac tctgcctggt
      301 gttgattctg ttcaatcaac acttgagggc agcaataaaa ttacatcaca cagactaggt
      361 aacttcatta tctgaaaata cgagcggtgt gatttggcca ggttgttcat ggataataaa
      421 cagttttgtt tattatttaa aaagtaaagc cataaagacg cctcgttggg taaaggagtt
      481 tgccaccaag ttggataacc tgagttctat tcctggaacc cagatactgt aaggaaagaa
      541 tcaactctca gaagttgacc tctgacctcc acgtgtgctc tgtgacagcc ataccgtttg
      601 ctcttcctgg tgctgcgttt aaaacgctga ccaaaagcaa ttcagagagg aaaggtttta
      661 tctggcttat agcttaaagt ctgtctttga gggaagtcag ggcatgttgg gaacacaaag
      721 gttcttgtgc ccaaagagca ttagggagcc agggttgtta aacacacagg gttctctcct
      781 cagtggagga gataaaatgc ctgttttccc acacagaaga ctagaagtag ctattgttaa
      841 tgacctgttg acatttgtgc tgtccgtgga gtcagaccaa actcaccttt tgctatatag
      901 gcagagctta cccaaatcct acaagatgtt tattccataa catctctccc tccactgctt
      961 ctaaaaaaaa cccatcctta gtggagatgc cacatgtatt ttatgtcccg ctaatctcta
     1021 tgctattggt cagagaccac actagattct aggatgttca gctgtaaagc tctccctcat
     1081 ctcatggtca cgtgtacttt gtaaaggagt ttctatataa taaaacctta aggtttatta
     1141 ttcacttaga attggattga ttgggctgga gaggttgctc agtggttaag agcactgact
     1201 gctcttccag aggtcctgag ttcaaatccc agcaaccaca tggtggctca caaccatctg
     1261 taatgggatc cgatgccctc ttctggtgtc tgaagacagc tacagcatac ttatatataa
     1321 taagtaaata aatatttttt taaaaaataa ttggattgat tgttccctgg aagctttttc
     1381 cccaaactgt actgtgttca aaatatgctg acagtgaacc ccctgacatt ggactccctg
     1441 agtctgatcc aggttggtga ttaagtgtga accactttca ttctcctctc tccatgggtt
     1501 cctttcctgc ttggatgact gcaggaatgc ttccctcaag ggtggtgtaa aggctattcc
     1561 tagttgtcaa cctgactgta tctggaatga actacaatcc agaattggag ggctcgcctg
     1621 tgatccagat cttgaggcta gaagacacac atttctgacc tggatcttgg cctggagatc
     1681 ttgagtcata gtggccatga aaagcttagg cccacacacc tttaatccca ggagactgag
     1741 tcaaggagat ctctgagttc aaagtcaacc tgggacaaaa caagtcccag atccaggggt
     1801 agtggcacac acctttaatc cgggccacac cttctgctgg ggactacata aggacgttgg
     1861 aagaaggaag attcactctt cttgcctgct tgcatccact tgccagcacc tctgttggaa
     1921 cccactgaac agaagagcgg ctgaaacaac tagcctcgtg ggactgagta actactggat
     1981 tcttggactt cccatccaca atagccattg ttggggagtc ggactacaga ctcaggaatt
     2041 gtgtgcctct aactttcagc ctgctagaag aagtcactgg gggaaaaaag gggacggttt
     2101 aaaaagtgat tatggcggcg agcactatgg aggcatacga gcaggtacag aagggccccc
     2161 tgaagctgaa aggtgtggca gagcttggcg tgacgaagcg gaggaagaag aaggacaaag
     2221 acaaggccaa gatgctggag accatgggga tgagaaagaa gagcgaggag gagaagcagc
     2281 actgtctgga caagcgcacg ccggcgcagg ctgcctttga aaagatgcag gagaagcggc
     2341 aaacggaaag gatcctgaag aaggcgtcga aaacccacaa gcagagagtg gaggacttca
     2401 accgacacct ggacacactc accgagcact atgacattcc caaggtcagc tggaccaagt
     2461 aa
//
LOCUS       NM_001025062             966 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 135 (Tas2r135),
            mRNA.
ACCESSION   NM_001025062 XM_578255
VERSION     NM_001025062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362748.1.
            
            On Jun 25, 2005 this sequence version replaced XM_578255.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..966
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="taste receptor, type 2, member 135"
                     /db_xref="GeneID:502757"
                     /db_xref="RGD:1561078"
     CDS             1..966
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="T2R28; T2R35; T2R135; taste receptor type 2 member
                     28"
                     /codon_start=1
                     /product="taste receptor type 2 member 135"
                     /protein_id="NP_001020233.1"
                     /db_xref="GeneID:502757"
                     /db_xref="RGD:1561078"
                     /translation="MGPIMSTGETSTAHTVLGCQITDKTVITLFVILVFSCLVAVVGN
                     GFIIIALGMKWLLRRTLSAHNKLLISLAASRFCLQCVVIGKNIYVFLNPSSFPYNPVI
                     QLLNLMWDFLTAATIWFCSLLGFFYCVKIATLTHPVFVWLKYRLPGWVPWMLLSAVGM
                     SSLTSILCFIGNHMIYQNYARRGHQPWNATGNSLRHSLEKFYFISIKIIMWTVPTVIF
                     SIFMSLLLVSLVRHMKKTLLALSELRDVWAQAHFKALLPLLSFIILFISCFLTLVLSS
                     ASSTPYQEFRYWMWQVVIHLCTVIHPIVILLSNPVLRVVMKRGCC"
     misc_feature    79..951
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="mammalian taste receptor 2, subtype 41, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R41-like; cd15018"
                     /db_xref="CDD:320146"
     misc_feature    79..951
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="mammalian taste receptor 2, subtype 41, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R41-like; cd15018"
                     /db_xref="CDD:320146"
     misc_feature    82..159
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320146"
     misc_feature    82..159
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320146"
     misc_feature    85..147
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    193..267
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320146"
     misc_feature    193..267
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320146"
     misc_feature    226..288
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    307..375
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320146"
     misc_feature    307..375
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320146"
     misc_feature    319..381
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    448..510
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    454..504
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320146"
     misc_feature    454..504
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320146"
     misc_feature    562..564
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES2.1); glycosylation site"
     misc_feature    598..669
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320146"
     misc_feature    598..669
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320146"
     misc_feature    622..684
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    742..819
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320146"
     misc_feature    742..819
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320146"
     misc_feature    760..822
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     misc_feature    850..927
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320146"
     misc_feature    850..927
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320146"
     misc_feature    859..921
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES2.1);
                     transmembrane region"
     exon            1..966
                     /gene="Tas2r135"
                     /gene_synonym="RGD1561078"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaccca ttatgtccac aggagaaacg agcacagctc atacagttct gggatgtcag
       61 attactgata agacagtcat cactttattt gtcattttag tcttttcgtg tctggtggca
      121 gtggtaggca atggatttat cattatagca ttgggcatga aatggttgct ccggaggaca
      181 ttgtcagctc ataataagtt actgatcagt ctagcagcct ctcgcttctg tcttcagtgt
      241 gtggtgatag gtaagaatat ttatgttttc ctgaatccat caagcttccc atacaaccct
      301 gtaatacagc tcctaaattt aatgtgggac ttcttgactg ctgcgaccat ctggttctgc
      361 tctttgctag gtttcttcta ttgtgtgaaa attgcaacct taacccatcc tgtctttgtc
      421 tggctaaagt acaggttgcc tgggtgggta ccatggatgt tgcttagtgc tgtggggatg
      481 tcgagcttaa ctagtatcct gtgtttcata ggcaatcata tgatatatca aaactatgca
      541 aggaggggcc atcaaccttg gaatgccact ggaaatagct taagacactc gcttgagaaa
      601 ttctacttca tttctataaa aataatcatg tggacagttc ctactgttat ctttagtatc
      661 tttatgagtt tgctcctcgt atctttggta agacacatga agaagactct cttggccctc
      721 tcagaacttc gggatgtttg ggcacaggcc cacttcaaag cccttcttcc tctgctctcc
      781 ttcatcatcc tttttatctc ctgttttctg acactggtac tcagttctgc cagcagcaca
      841 ccgtatcagg aattcaggta ctggatgtgg caggtggtga ttcatctgtg cacagtgata
      901 caccccattg ttatactcct cagtaacccc gttttgagag tggtgatgaa gaggggctgc
      961 tgctga
//
LOCUS       NM_001037632            1505 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Sp7 transcription factor (Sp7), transcript
            variant 1, mRNA.
ACCESSION   NM_001037632
VERSION     NM_001037632.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   da Silva Sasso,G.R., Florencio-Silva,R., Sasso-Cerri,E., Gil,C.D.,
            de Jesus Simoes,M. and Cerri,P.S.
  TITLE     Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix
            during the early steps of intramembranous ossification of the
            alveolar process in rat embryos
  JOURNAL   Dev Biol 478, 133-143 (2021)
   PUBMED   34245724
  REMARK    GeneRIF: Spatio-temporal immunolocalization of VEGF-A, Runx2, and
            osterix during the early steps of intramembranous ossification of
            the alveolar process in rat embryos.
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Pokrovskaya,L.A., Nadezhdin,S.V., Zubareva,E.V., Burda,Y.E. and
            Gnezdyukova,E.S.
  TITLE     Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells
            during Culturing in Osteogenic-Conditioned Medium
  JOURNAL   Bull Exp Biol Med 169 (4), 571-575 (2020)
   PUBMED   32910396
  REMARK    GeneRIF: Expression of RUNX2 and Osterix in Rat Mesenchymal Stem
            Cells during Culturing in Osteogenic-Conditioned Medium.
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Xi,Y., Miao,X., Li,Y., Lai,K., Du,X., Jiang,Z., Wang,Y. and Yang,G.
  TITLE     BMP2-mimicking peptide modified with E7 coupling to calcined bovine
            bone enhanced bone regeneration associating with activation of the
            Runx2/SP7 signaling axis
  JOURNAL   J Biomed Mater Res B Appl Biomater 108 (1), 80-93 (2020)
   PUBMED   30912295
  REMARK    GeneRIF: BMP2-mimicking peptide modified with E7 coupling to
            calcined bovine bone enhanced bone regeneration associating with
            activation of the Runx2/SP7 signaling axis.
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Fukuda,M., Yoshizawa,T., Karim,M.F., Sobuz,S.U., Korogi,W.,
            Kobayasi,D., Okanishi,H., Tasaki,M., Ono,K., Sawa,T., Sato,Y.,
            Chirifu,M., Masuda,T., Nakamura,T., Tanoue,H., Nakashima,K.,
            Kobashigawa,Y., Morioka,H., Bober,E., Ohtsuki,S., Yamagata,Y.,
            Ando,Y., Oike,Y., Araki,N., Takeda,S., Mizuta,H. and Yamagata,K.
  TITLE     SIRT7 has a critical role in bone formation by regulating lysine
            acylation of SP7/Osterix
  JOURNAL   Nat Commun 9 (1), 2833 (2018)
   PUBMED   30026585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   Amorim,B.R., Okamura,H., Yoshida,K., Qiu,L., Morimoto,H. and
            Haneji,T.
  TITLE     The transcriptional factor Osterix directly interacts with RNA
            helicase A
  JOURNAL   Biochem Biophys Res Commun 355 (2), 347-351 (2007)
   PUBMED   17303075
REFERENCE   7  (bases 1 to 1505)
  AUTHORS   Wang,B.L., Dai,C.L., Quan,J.X., Zhu,Z.F., Zheng,F., Zhang,H.X.,
            Guo,S.Y., Guo,G., Zhang,J.Y. and Qiu,M.C.
  TITLE     Parathyroid hormone regulates osterix and Runx2 mRNA expression
            predominantly through protein kinase A signaling in osteoblast-like
            cells
  JOURNAL   J Endocrinol Invest 29 (2), 101-108 (2006)
   PUBMED   16610234
  REMARK    GeneRIF: Parathyroid hormone (1-34) regulates osterix mRNA
            expression, in rat osteoblast-like cell line UMR 106, in a dose-
            and time-dependent manner.
REFERENCE   8  (bases 1 to 1505)
  AUTHORS   Koga,T., Matsui,Y., Asagiri,M., Kodama,T., de Crombrugghe,B.,
            Nakashima,K. and Takayanagi,H.
  TITLE     NFAT and Osterix cooperatively regulate bone formation
  JOURNAL   Nat Med 11 (8), 880-885 (2005)
   PUBMED   16041384
REFERENCE   9  (bases 1 to 1505)
  AUTHORS   Milona,M.A., Gough,J.E. and Edgar,A.J.
  TITLE     Expression of alternatively spliced isoforms of human Sp7 in
            osteoblast-like cells
  JOURNAL   BMC Genomics 4, 43 (2003)
   PUBMED   14604442
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1505)
  AUTHORS   Nakashima,K., Zhou,X., Kunkel,G., Zhang,Z., Deng,J.M.,
            Behringer,R.R. and de Crombrugghe,B.
  TITLE     The novel zinc finger-containing transcription factor osterix is
            required for osteoblast differentiation and bone formation
  JOURNAL   Cell 108 (1), 17-29 (2002)
   PUBMED   11792318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001413.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1505
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Sp7 transcription factor"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
     exon            1..239
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="upstream in-frame stop codon"
     exon            240..1505
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1505
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="isoform 1 is encoded by transcript variant 1;
                     osterix; Transcription factor Sp7"
                     /codon_start=1
                     /product="transcription factor Sp7 isoform 1"
                     /protein_id="NP_001032721.1"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
                     /translation="MLTAACSKFGGSSPLRDSTALGKGGTKKPYTDLSAPKTMGDAYP
                     APFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGAQDPGLLVPKGHSSSDCLP
                     SVYTSLDMSHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGT
                     LSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQ
                     LEGSGAGKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELERLGAAAAGLRKKPIHSCH
                     IPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFT
                     CLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSVGEEEANQPPRSSTSPA
                     PPEKAPGGSPEQSNLLEI"
     misc_feature    273..1094
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="N-terminal domains of transcription factor
                     Specificity Proteins (SP) 6-9, and similar proteins;
                     Region: SP6-9_N; cl41771"
                     /db_xref="CDD:425402"
     misc_feature    273..1094
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="N-terminal domains of transcription factor
                     Specificity Proteins (SP) 6-9, and similar proteins;
                     Region: SP6-9_N; cl41771"
                     /db_xref="CDD:425402"
     misc_feature    1104..1163
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1104..1163
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1116..1118,1122..1124,1128..1130,1134..1139,
                     1146..1151,1158..1160,1206..1208,1212..1214,1224..1229,
                     1236..1241,1248..1250,1290..1292,1296..1298,1302..1304,
                     1308..1313,1320..1325,1332..1334)
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1116..1118,1122..1124,1128..1130,1134..1139,
                     1146..1151,1158..1160,1206..1208,1212..1214,1224..1229,
                     1236..1241,1248..1250,1290..1292,1296..1298,1302..1304,
                     1308..1313,1320..1325,1332..1334)
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1137..1220
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1137..1220
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1185..1253
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1185..1253
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1227..1304
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1227..1304
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1275..1337
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1275..1337
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
ORIGIN      
        1 agcagcagca gcagcagcag cagcagtagc agcagcagca gcagcagcag cagaagctgc
       61 cgcgccactg agtagcggca aggactccga gtcaagagtc ggattctagg attggatctg
      121 agtgagccgg cctgagagag gagaagatcc ctcccagcgc cctcgggcca cccattgcca
      181 gtaatcttcg tgccagacct cttgagagga gacgggacag ccaaccctag cctccccagg
      241 aagaagctca ctatggctcc agtcccctgg ccatgctgac agcagcctgc agcaagtttg
      301 gtggctccag ccctctgcga gactcaacag ccctgggaaa aggaggcaca aagaagccat
      361 acactgacct ttcagccccc aaaaccatgg gggacgccta cccagctccc ttctcaagca
      421 ccaatggact cctctcccct gcaggcagtc ccccggcccc ggcctctggc tatgccaatg
      481 actacccacc ctttccccac tcatttcctg ggcccactgg tgcccaagac ccggggctgc
      541 tggtgccgaa ggggcacagc tcttctgact gcctgcctag tgtctacacg tccttggata
      601 tgtcccatcc ctacggctcc tggtacaagg cgggcatcca tgcaggcatc tcaccaggtc
      661 ctggcaacac tcctacccct tggtgggaca tgcaccctgg gggcaattgg ttaggtggtg
      721 ggcagggcca gggtgatggg ctgcaaggga cactgtccac aggccctgcc cagcctccac
      781 tgaaccccca gctgcctact tacccgtctg actttgcccc ccttaaccca gctccctatc
      841 cagcacccca cctcttgcaa ccaggtcccc agcatgtcct accccaagat gtctataagc
      901 ccaaggcagt tggcaatagt gggcaactgg aggggagtgg tgcaggcaaa cctccccggg
      961 gtgcaggcac agggggcagt ggtggatatg caggcagtgg ggcagggcgt tctacctgcg
     1021 actgccccaa ctgtcaggag ctagagcggc tgggggcagc agcggctggg ctgaggaaga
     1081 agcccattca cagctgccac atccccggct gcggcaaggt gtacggcaag gcttcgcatc
     1141 tgaaagccca cttgcgctgg cacactggcg agaggccttt cgtctgcaac tggcttttct
     1201 gtggcaagag gttcacccgc tctgacgagc tggagcgcca cgtgcgcact cacacccggg
     1261 agaagaagtt cacctgtctg ctctgctcca agcgctttac ccgaagcgac cacttgagca
     1321 aacatcagcg cacccacggg gagccaggtc ccgggccgcc cccaagtggc cctaaggagc
     1381 tgggggaggg tcgcagcgtc ggggaagaag aagccaatca gccgccccga tcttccacct
     1441 cgcctgcacc cccagaaaaa gcccctggag gcagcccaga gcagagcaac ctgctagaga
     1501 tctga
//
LOCUS       NM_001025280            1305 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 10, member 5 (Slc10a5),
            mRNA.
ACCESSION   NM_001025280 XM_226952
VERSION     NM_001025280.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Fernandes,C.F., Godoy,J.R., Doring,B., Cavalcanti,M.C.,
            Bergmann,M., Petzinger,E. and Geyer,J.
  TITLE     The novel putative bile acid transporter SLC10A5 is highly
            expressed in liver and kidney
  JOURNAL   Biochem Biophys Res Commun 361 (1), 26-32 (2007)
   PUBMED   17632081
  REMARK    GeneRIF: Molecular cloning and characterization of SLC10A5 as an
            orphan carrier with yet non-identified substrates.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ074435.1.
            
            On Jul 13, 2005 this sequence version replaced XM_226952.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ074435.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1305
                     /gene="Slc10a5"
                     /note="solute carrier family 10, member 5"
                     /db_xref="GeneID:310230"
                     /db_xref="RGD:1306036"
     CDS             1..1305
                     /gene="Slc10a5"
                     /note="sodium/bile acid cotransporter 5; Na(+)/bile acid
                     cotransporter 5; solute carrier family 10 (sodium/bile
                     acid cotransporter family), member 5"
                     /codon_start=1
                     /product="sodium/bile acid cotransporter 5 precursor"
                     /protein_id="NP_001020451.1"
                     /db_xref="GeneID:310230"
                     /db_xref="RGD:1306036"
                     /translation="MSGKLFIILLLLVTPGEARKSFLRFLNIQNPEMLSFTKPEETVI
                     VRSSYEGKRPHSSYLLVKLEDPTVLQVVNVTKTSLDFTDFTINLKTFPGETNLTMQLW
                     ESEGRQTRLIEEITNIRVSVFRQTEDSLFQEPIHVNSSVFLLVLLMILLNKCAFGCKI
                     ELQVLQTVWKRPLPILLGAVTQFFLMPFCGFLLSQILGLSKAQAFGFVMTCTCPGGGG
                     GYLFALLLEGDVTLAILMACTSTSLALIMMPVNSYLYSCLLGLAGVFHVPVLKIVSTL
                     LFILTPVSIGIVIKHRMPKKAVCLERVVQPLSLTLMLVGVYLAFRMGLVFLRMANLEV
                     FLLGLLVPVLGFSFGYSFAKVYLLPLPVCKTVAIESGMLNSFLALAIIQLSFPQSKAY
                     EASVAPFTVAMCSSCEMLLLLLVYKAKKRPLLSTENEKAPLV"
     sig_peptide     1..54
                     /gene="Slc10a5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     55..1302
                     /gene="Slc10a5"
                     /product="Sodium/bile acid cotransporter 5.
                     /id=PRO_0000263747"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1)"
     misc_feature    217..219
                     /gene="Slc10a5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4JLT5.1); glycosylation site"
     misc_feature    286..288
                     /gene="Slc10a5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4JLT5.1); glycosylation site"
     misc_feature    388..450
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    454..1263
                     /gene="Slc10a5"
                     /note="Sodium Bile acid symporter family; Region: SBF;
                     cl19217"
                     /db_xref="CDD:450274"
     misc_feature    454..1263
                     /gene="Slc10a5"
                     /note="Sodium Bile acid symporter family; Region: SBF;
                     cl19217"
                     /db_xref="CDD:450274"
     misc_feature    517..579
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    586..648
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    697..765
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    805..867
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    919..981
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    994..1056
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    1096..1158
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     misc_feature    1186..1248
                     /gene="Slc10a5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4JLT5.1);
                     transmembrane region"
     exon            1..1305
                     /gene="Slc10a5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctggaa aacttttcat aattctcctt ttgttggtga ccccgggaga agcaaggaag
       61 tcatttctca gatttctgaa tatacaaaat ccagaaatgc tgtcgtttac gaagccagaa
      121 gaaaccgtca ttgtaaggtc cagctatgaa ggtaagcggc ctcactccag ctacctgctt
      181 gtgaagttgg aggatcctac agtgctgcag gtggtgaatg tgaccaagac ctccctggac
      241 ttcacagact tcaccatcaa cctgaagacg ttcccaggag agacaaacct caccatgcag
      301 ctctgggagt ctgaaggtag gcaaacaaga ctcatcgaag agataaccaa tatcagagtg
      361 agcgtgttca gacagacaga ggacagtctc ttccaggaac caatccacgt caacagctcc
      421 gtcttcctgc ttgtcttatt gatgatcctt ttaaataaat gcgcctttgg ctgcaagatt
      481 gaattacagg tgctccaaac agtgtggaag agacctttgc caatacttct tggggcggtt
      541 acacagtttt ttcttatgcc gttctgtggc tttctcttgt ctcagatttt gggcttgtca
      601 aaggcacagg cttttggatt tgtaatgacc tgcacatgcc caggaggggg tgggggctat
      661 ctctttgctc tccttctaga aggggacgtc actttggcca ttttgatggc ttgcacgtca
      721 acgtccctgg ccctcatcat gatgcctgtc aactcgtact tatacagttg cctactcggg
      781 ttagcaggtg tatttcacgt tcctgtctta aagattgtgt ctactcttct tttcatactt
      841 acgccagtat ccatcggcat agtcattaag cacagaatgc ctaaaaaagc agtctgtcta
      901 gagagagtgg tgcagcctct gagtttgact ttaatgttgg tgggagtcta cttggctttc
      961 aggatgggac tggtgtttct gagaatggct aacctagagg tgtttctttt ggggcttctg
     1021 gttcccgtac tgggcttttc atttgggtat tcctttgcta aagtctacct gctgccgctt
     1081 cctgtttgca aaacagtcgc aatcgaaagt gggatgttga atagtttctt agccctggcc
     1141 attattcagc tttcttttcc acagtccaag gcatatgagg cctccgtggc tccttttaca
     1201 gtagcgatgt gttctagctg tgaaatgttg ctgctccttc tggtctacaa ggctaagaag
     1261 aggccactcc ttagcacaga aaatgaaaag gctcctctcg tttaa
//
LOCUS       NM_175587               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 7h (Taar7h),
            mRNA.
ACCESSION   NM_175587
VERSION     NM_175587.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Ferrero,D.M., Wacker,D., Roque,M.A., Baldwin,M.W., Stevens,R.C. and
            Liberles,S.D.
  TITLE     Agonists for 13 trace amine-associated receptors provide insight
            into the molecular basis of odor selectivity
  JOURNAL   ACS Chem Biol 7 (7), 1184-1189 (2012)
   PUBMED   22545963
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380194.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="trace amine-associated receptor 7h"
                     /db_xref="GeneID:294130"
                     /db_xref="RGD:631385"
     CDS             1..1077
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="taR-6; taR-7h; trace amine receptor 7h; trace amine
                     receptor 6"
                     /codon_start=1
                     /product="trace amine-associated receptor 7h"
                     /protein_id="NP_783177.1"
                     /db_xref="GeneID:294130"
                     /db_xref="RGD:631385"
                     /translation="MATDDESFPWDQDSILSRDLLSALSPQLCYENLNRSCVRSPYSP
                     GPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADLLVGLTVMP
                     FSMVRSVEGCWYFGDSYCKLHTSFDMSFCCSSLLHLCFISVDRYIAVSDPLIYPIRFT
                     ASVSGKCITFSWFLSIIYGFSLIYTGASEAGLKDLVSALSCVGGCQIPMNQSCVLINF
                     LLFLVPTLVMMTVYSKIFLIAKQQAQNMEKMSKQTTRASDSYKDRVAKRERKAAKTLG
                     IAVAAFLLSWLPYLIDSIIDAFLGFITPSYVYEILVWIVYYNSAMNPLIYAFFYPWFR
                     NAIKLIVTGKILKQNSSTTNLFSE"
     misc_feature    100..102
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y4.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    148..222
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..312
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    361..429
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    376..429
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    496..546
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    499..561
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..699
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..630
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y4.1); glycosylation site"
     misc_feature    652..714
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    814..882
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    823..885
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    913..990
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    928..999
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y4.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7h"
                     /gene_synonym="Ta6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctacag atgatgagag ttttccctgg gatcaggaca gcatcctgag cagagatctg
       61 ctctcagcct tgtctcccca gctgtgctat gagaacctga acagatcctg tgtcaggagc
      121 ccatactccc caggccctcg cctcatcctc tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactcg
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tgttggtggg tctgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttgggga cagttactgt
      361 aaactacaca cctcttttga tatgtcattt tgttgttctt ctctcttaca cttgtgcttc
      421 atctctgttg atagatatat tgcagtcagt gaccccctga tctaccccat caggttcact
      481 gcatctgttt ctggcaagtg catcaccttc tcctggttcc tgtccatcat ctatggcttt
      541 tccctcattt acacaggagc aagtgaagct gggctgaagg atctagtgag tgccctcagc
      601 tgtgtgggtg gatgtcaaat cccaatgaat caaagctgtg tccttattaa tttcctatta
      661 tttcttgttc ccacgcttgt gatgatgact gtctactcta agattttcct cattgcaaag
      721 cagcaggctc agaacatgga gaagatgagc aagcagacca ccagggcatc tgacagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccctgggcat tgcagtggct
      841 gccttcctcc tttcatggct gccatacctc attgactcca tcattgacgc cttcctgggg
      901 ttcatcacgc cctcttatgt gtatgaaatc ctagtttgga tagtttacta taactcagcc
      961 atgaaccctt tgatatatgc tttcttttat ccttggtttc gaaacgccat caaactcatt
     1021 gtcactggca aaatcttgaa gcagaattct tcaaccacca acctgttttc tgagtag
//
LOCUS       NM_001037522             291 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus defensin beta 39 (Defb39), mRNA.
ACCESSION   NM_001037522
VERSION     NM_001037522.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY621366.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY621366.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..291
                     /gene="Defb39"
                     /note="defensin beta 39"
                     /db_xref="GeneID:641646"
                     /db_xref="RGD:1563816"
     exon            1..130
                     /gene="Defb39"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Defb39"
                     /note="upstream in-frame stop codon"
     CDS             70..291
                     /gene="Defb39"
                     /note="BD-39; beta-defensin 39"
                     /codon_start=1
                     /product="beta-defensin 39 precursor"
                     /protein_id="NP_001032611.1"
                     /db_xref="GeneID:641646"
                     /db_xref="RGD:1563816"
                     /translation="MKISCFLLLVLSLSCFQINSVSGIDSVKCFQKNNTCHTIRCPYF
                     QDEVGTCYEGRGKCCQKRLLSIRVPKKKV"
     sig_peptide     70..138
                     /gene="Defb39"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     139..288
                     /gene="Defb39"
                     /product="Beta-defensin 39. /id=PRO_0000352715"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32ZF7.1)"
     misc_feature    142..249
                     /gene="Defb39"
                     /note="Beta defensin; Region: Defensin_beta; pfam00711"
                     /db_xref="CDD:459914"
     misc_feature    142..249
                     /gene="Defb39"
                     /note="Beta defensin; Region: Defensin_beta; pfam00711"
                     /db_xref="CDD:459914"
     exon            131..291
                     /gene="Defb39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggttcat ctttgagcta agctttccag ctctggcctt gtctttaatc agctcgctgt
       61 gcagcaagca tgaagatctc ctgctttctg ctgctggtcc tctctctgtc ctgcttccag
      121 atcaactcag tgtctggtat tgattcggta aaatgttttc aaaagaacaa cacctgtcac
      181 accatccgat gcccatattt ccaagacgag gtcggcacgt gttatgaagg aagaggcaaa
      241 tgttgccaaa aacgcctttt gtctatccga gttccaaaga agaaggtgta a
//
LOCUS       NM_023951                567 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus SEBOX homeobox (Sebox), mRNA.
ACCESSION   NM_023951
VERSION     NM_023951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Moreno,D.L., Salazar,Z., Betancourt,M., Casas,E., Ducolomb,Y.,
            Gonzalez,C. and Bonilla,E.
  TITLE     Sebox plays an important role during the early mouse oogenesis in
            vitro
  JOURNAL   Zygote 22 (1), 64-68 (2014)
   PUBMED   22805237
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Kim,K.H., Kim,E.Y. and Lee,K.A.
  TITLE     SEBOX is essential for early embryogenesis at the two-cell stage in
            the mouse
  JOURNAL   Biol Reprod 79 (6), 1192-1201 (2008)
   PUBMED   18753614
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Cinquanta,M., Rovescalli,A.C., Kozak,C.A. and Nirenberg,M.
  TITLE     Mouse Sebox homeobox gene expression in skin, brain, oocytes, and
            two-cell embryos
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8904-8909 (2000)
   PUBMED   10922053
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF284338.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..567
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="SEBOX homeobox"
                     /db_xref="GeneID:58922"
                     /db_xref="RGD:62077"
     CDS             1..567
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="homeobox OG-9; skin-, embryo-, brain- and
                     oocyte-specific homeobox; OG9 homeobox"
                     /codon_start=1
                     /product="homeobox protein SEBOX"
                     /protein_id="NP_076441.1"
                     /db_xref="GeneID:58922"
                     /db_xref="RGD:62077"
                     /translation="MASPVEASPGCASGLGPHRRKRTTFSVGQLLELERVFAARPYPD
                     ISTREHLAQITHLPEAKIQVWFQNRRAKRIKDRKPGALNARLELPPNCSLPDTPQLSW
                     DPGTPSHPLHSTSSAQQTSACPPQTSCLAPILGPGQSWSGAKAAAPWGTSEVSGVHSL
                     EQIVPQTSLGNLSDLIYTSAIVTNVDHS"
     misc_feature    <37..363
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    <37..363
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    55..216
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    55..216
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    238..375
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERS8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..28
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /inference="alignment:Splign:2.1.0"
     exon            29..189
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /inference="alignment:Splign:2.1.0"
     exon            190..567
                     /gene="Sebox"
                     /gene_synonym="Og9x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccagtc ctgtggaggc atctccaggc tgtgccagtg ggttgggtcc ccatcggagg
       61 aagaggacca cttttagtgt tgggcagttg ctggagctgg aacgggtatt tgcagctagg
      121 ccctatcctg acatcagcac ccgtgagcac ctggctcaga taactcacct gccagaagcc
      181 aagatccagg tgtggttcca gaaccgtcga gccaagagaa tcaaggacag aaagccagga
      241 gccctaaacg ccaggctgga gcttccccca aactgttctc ttccagacac tccccagcta
      301 tcttgggacc ctggaacacc aagccatcct ctacactcta ccagttcagc tcagcagact
      361 tcggcatgcc caccacagac ctcctgccta gcccccattt tgggtccagg gcagagttgg
      421 tcaggggcta aagctgcagc cccatggggg acaagtgagg tgtcaggagt tcactcttta
      481 gagcaaattg ttcctcagac ttcactgggc aacctgtctg accttatcta tacctcagcc
      541 atcgtcacca atgtagacca ctcctaa
//
LOCUS       NM_001008821            1296 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 40 (Krt40), mRNA.
ACCESSION   NM_001008821 XM_220947
VERSION     NM_001008821.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004036.1.
            
            On Jan 5, 2005 this sequence version replaced XM_220947.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004036.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1296
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="keratin 40"
                     /db_xref="GeneID:287679"
                     /db_xref="RGD:1359145"
     CDS             1..1296
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="K40; CK-40; cytokeratin-40; type I hair keratin
                     KA36; keratin 40, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 40"
                     /protein_id="NP_001008821.1"
                     /db_xref="GeneID:287679"
                     /db_xref="RGD:1359145"
                     /translation="MASEGSPDCCSSEPYAGASSCTTASFCPTSTTYLPSTCATSRCQ
                     TPSFLCRAHLPAGCLSPCYLTGGCNSPCLVGNCAWCEEGTFNSNEKETMQFLNDRLAS
                     YLERVRSLEENNAELECRIREQCEPDATPVCPDYQRYFDTIEELQQKILCTKAENSRL
                     AVQVDNCKLAADDFRSKYESELSLRQLVENDISGLRGILGELTLCKSDLEAHVESLKD
                     DLLCLKKDHEEEVNLLREQLGDRLNVELDTAPTVDLNKVLDEMRCQYERVLANNRRDA
                     EEWFAAQTEELNQQQMSSAEQLQGCQTEMLELKRTANTLEIELQAQQTLTESLECTVA
                     ETEAQYSTQLAQMQCLIDSVEHQLAEIRCDLERQNQEYKVLLDTKARLECEINTYRGL
                     LEKEDSRLPCNPGSTASISNSACEPCSAYVICTVENCCA"
     misc_feature    1..267
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Head"
     misc_feature    262..1197
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    262..1197
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    268..372
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Coil 1A"
     misc_feature    373..405
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Linker 1"
     misc_feature    406..708
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Coil 1B"
     misc_feature    709..756
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Linker 12"
     misc_feature    757..1188
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Coil 2"
     misc_feature    1012..1014
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (Q6IFW2.1); other site"
     misc_feature    1189..1293
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFW2.1);
                     Region: Tail"
     exon            1..447
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            448..530
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            531..687
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            688..849
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            850..975
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1196
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1296
                     /gene="Krt40"
                     /gene_synonym="Ka36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttccg aaggctcccc tgactgctgc tcttctgagc cctatgcagg ggcatcgagc
       61 tgcacaactg cctcattctg ccccaccagc acaacttacc ttcccagcac ctgcgccaca
      121 tccagatgtc aaaccccgag cttcctctgc agggctcacc tcccggccgg ttgcctctca
      181 ccgtgctact tgactggcgg ttgtaacagt ccttgcctgg tggggaactg tgcatggtgt
      241 gaagaaggga cgttcaacag taatgagaag gagaccatgc agttcctgaa tgacagattg
      301 gccagctacc tagagcgggt gagaagcctg gaagagaaca atgcagagct ggagtgcagg
      361 atccgagagc aatgtgagcc cgatgccaca ccggtctgcc cggattatca gcggtacttt
      421 gacaccattg aagagctaca acaaaagata ttgtgcacga aggcagagaa ttctagactt
      481 gccgtgcagg tggacaactg caaactggct gccgatgatt ttaggtcaaa gtatgagagc
      541 gaactgtccc tgcgccagct ggtagagaat gacatcagtg gtcttcgtgg gatcctgggt
      601 gaactgaccc tgtgcaagtc agatctggag gcccatgtgg agtctctgaa agatgatcta
      661 ctttgcctta agaaagacca tgaagaggag gtcaacttgc ttcgtgagca gcttggagat
      721 cgactcaatg tggagctgga cactgccccc actgtggacc tcaacaaggt cctggatgag
      781 atgcggtgtc aatatgagag ggtgctggcc aacaaccgca gggatgcgga ggagtggttc
      841 gctgctcaga cagaagagct gaaccagcag cagatgtcca gtgcagagca gctgcagggc
      901 tgccagactg agatgctgga gttgaagcgt acagccaaca ctctggaaat tgagctccag
      961 gcacagcaaa ccctgacaga gtctctggag tgtactgtgg cagaaactga agcccagtac
     1021 agcacacaac tggcccaaat gcagtgccta attgatagtg tggagcacca gctggctgag
     1081 atccgctgtg acctggagcg tcagaaccag gagtacaagg tgctactgga caccaaggcc
     1141 cggctggagt gtgagatcaa cacatacagg ggcctgctgg agaaagagga cagcagactc
     1201 ccctgcaatc caggctccac agcctccata tcaaacagcg catgtgagcc gtgttcagcc
     1261 tacgtgattt gcacggttga aaactgctgt gcatga
//
LOCUS       NM_001107402            2878 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus desmocollin 3 (Dsc3), mRNA.
ACCESSION   NM_001107402 XM_001053804 XM_226122
VERSION     NM_001107402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Xu,X., Dong,C. and Vogel,B.E.
  TITLE     Hemicentins assemble on diverse epithelia in the mouse
  JOURNAL   J Histochem Cytochem 55 (2), 119-126 (2007)
   PUBMED   17015624
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Den,Z., Cheng,X., Merched-Sauvage,M. and Koch,P.J.
  TITLE     Desmocollin 3 is required for pre-implantation development of the
            mouse embryo
  JOURNAL   J Cell Sci 119 (Pt 3), 482-489 (2006)
   PUBMED   16418220
REFERENCE   3  (bases 1 to 2878)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   4  (bases 1 to 2878)
  AUTHORS   Kowalczyk,A.P., Palka,H.L., Luu,H.H., Nilles,L.A., Anderson,J.E.,
            Wheelock,M.J. and Green,K.J.
  TITLE     Posttranslational regulation of plakoglobin expression. Influence
            of the desmosomal cadherins on plakoglobin metabolic stability
  JOURNAL   J Biol Chem 269 (49), 31214-31223 (1994)
   PUBMED   7983064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226122.4, XM_001053804.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760400, SAMEA5760434
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2878
                     /gene="Dsc3"
                     /note="desmocollin 3"
                     /db_xref="GeneID:307563"
                     /db_xref="RGD:1311782"
     exon            1..256
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    125..127
                     /gene="Dsc3"
                     /note="upstream in-frame stop codon"
     CDS             176..2878
                     /gene="Dsc3"
                     /codon_start=1
                     /product="desmocollin-3"
                     /protein_id="NP_001100872.1"
                     /db_xref="GeneID:307563"
                     /db_xref="RGD:1311782"
                     /translation="MAMAMAVPELRSLPYRAPFTKFLLTLWVFSFVGEACKDVTFYVP
                     STLEADKIIGRVSLKECLSSADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQL
                     SDSKMRKQKEITVILERQKEVMMKRHTNETVLRRAKRRWAPIPCSMQENSLGPFPLFL
                     QQVQSDSAQNYNIFYSISGRGVDQEPLNLFFIERDTGNLYCTRPVDREEYDVFDLIAY
                     ASTADGYSADLPLPLPIKVEDENDNYPLFTEAIYNFEVPESSRLGTVVGTVCATDKDE
                     PDTMHTRLKYSILEQSPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLILKVQDMNG
                     QFFGLISTSTCIITVQDSNDNAPTFRQNAYETSVEENTYNVEILRIPVDDKDMVNSAN
                     WKANFTILKGNENGWFKITTDPATNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIRD
                     VASRIPTMNRAMVTVQVRDQNEGPECKPREQIVRIKENSAIGSKINGYKAYDPETKNS
                     NGLRYKKLQDPKDWVSIEEVSGSLTISKILDREIMAPRNDLYNITVMAIDQEGRSCTG
                     TLAVNIEDMNDNAPEIIQDDIVICKPRMGYTDISAVDPDEPIHGPPFQFALASSSPEV
                     NRIWTLNQVNDTAARLSYQKTADVQIYSVPVTVTDRAGQSATKILRVNLCDCTHPSQC
                     LLRSRRAGITLGKWAILAILLGIALLFSVLLTLVCGVVTAQKGKHFPEDLAQQNLIIS
                     NTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRV
                     AGHHHTLDSCRGGHMETDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTY
                     NYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR"
     misc_feature    272..520
                     /gene="Dsc3"
                     /note="Cadherin prodomain like; Region: Cadherin_pro;
                     smart01055"
                     /db_xref="CDD:214999"
     misc_feature    272..520
                     /gene="Dsc3"
                     /note="Cadherin prodomain like; Region: Cadherin_pro;
                     smart01055"
                     /db_xref="CDD:214999"
     misc_feature    605..889
                     /gene="Dsc3"
                     /note="Cadherin domain; Region: Cadherin; pfam00028"
                     /db_xref="CDD:394985"
     misc_feature    605..889
                     /gene="Dsc3"
                     /note="Cadherin domain; Region: Cadherin; pfam00028"
                     /db_xref="CDD:394985"
     misc_feature    926..1240
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    926..1240
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(947..952,1121..1123,1127..1129,1226..1228,
                     1232..1237)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(947..952,1121..1123,1127..1129,1226..1228,
                     1232..1237)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1265..1591
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1265..1591
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1283..1288,1457..1459,1463..1465,1580..1582,
                     1586..1591)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1283..1288,1457..1459,1463..1465,1580..1582,
                     1586..1591)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1613..1909
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1613..1909
                     /gene="Dsc3"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1634..1639,1790..1792,1796..1798,1895..1897,
                     1901..1906)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1634..1639,1790..1792,1796..1798,1895..1897,
                     1901..1906)
                     /gene="Dsc3"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1970..2197
                     /gene="Dsc3"
                     /note="Cadherin repeat-like domain; Region: CA_like;
                     cl46864"
                     /db_xref="CDD:481204"
     misc_feature    1970..2197
                     /gene="Dsc3"
                     /note="Cadherin repeat-like domain; Region: CA_like;
                     cl46864"
                     /db_xref="CDD:481204"
     misc_feature    2726..2860
                     /gene="Dsc3"
                     /note="Cadherin, Y-type LIR-motif; Region:
                     CADH_Y-type_LIR; pfam01049"
                     /db_xref="CDD:460041"
     misc_feature    2726..2860
                     /gene="Dsc3"
                     /note="Cadherin, Y-type LIR-motif; Region:
                     CADH_Y-type_LIR; pfam01049"
                     /db_xref="CDD:460041"
     exon            257..341
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..541
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..661
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..817
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            818..962
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1129
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1264
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1450
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1710
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1853
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2078
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2303
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2425
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2680
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2878
                     /gene="Dsc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgagcgtc tccttagtcc aatccagttt caggcgagaa catgcttcta ggcaaagaag
       61 cttgagagag gccagaacaa cttctagaca agctgctgtg gaaaacctcc tgtgccctgg
      121 ctcttagagt ccttacttgg tgcccgcctg cgtcctcctg aggcagcacc gaacgatggc
      181 gatggcgatg gcggtccctg agctccggag cctgccgtac agggcaccat tcacgaagtt
      241 cctgctgacc ctctgggtct tcagttttgt tggtgaagcc tgtaaagatg tgacctttta
      301 tgtaccttca acactagagg cagacaagat catcggaaga gttagtttga aggagtgtct
      361 cagctcggct gatggtatca tgccaagcga tcctgacttc agagttctag atgacgggtc
      421 agtttatcct accagagctg ttgtgttgtc tgatgagaaa agatcattta ccattcagct
      481 ttctgattca aagatgcgga aacagaaaga gatcactgta atcctggagc gccagaagga
      541 ggtaatgatg aaaagacaca ctaatgaaac tgtcctcaga agagccaaga ggagatgggc
      601 acccattccg tgttcaatgc aagaaaattc cttgggtccc ttcccattgt ttcttcaaca
      661 ggttcagtct gattcagctc agaactacaa tatcttctac tcaataagcg ggcgtggagt
      721 tgaccaagaa ccactgaatt tgtttttcat tgagagagac actgggaatc tttattgtac
      781 tcggcctgtg gatcgtgaag aatatgatgt ttttgatttg attgcctatg catccactgc
      841 agatggctac tcagcagatt tacctctccc cctgcccatc aaagtagagg atgaaaatga
      901 caattaccct ctttttacag aagcaattta caattttgaa gttccagaaa gcagtagact
      961 tggtaccgtg gtgggaacgg tgtgtgctac ggacaaagat gaacccgata cgatgcacac
     1021 gcgcctcaag tacagcatct tggagcagag tccgccgtcc ccagggctct tttctgtgca
     1081 ccctgacacc ggcgtcatca ccactgtctc tcactacatg gacagagagg ttgtagacaa
     1141 gtacaaactg atcttgaaag tccaggacat gaatggccaa ttctttggac tcatcagcac
     1201 atcaacttgt atcataacag tgcaagattc caatgacaat gctcccacat tcagacaaaa
     1261 tgcttatgaa acttctgtgg aggaaaatac atataatgtt gagatcttgc gcatacctgt
     1321 agatgataag gacatggtta acagtgccaa ctggaaggca aatttcacca tcttaaaagg
     1381 aaatgaaaac ggctggttca aaatcacgac agacccagcg acaaatgagg gtgttctgtg
     1441 tgtcgtgaag ccactggatt atgaagaaaa tcgtcaagtg accctagaga tcggtgtgaa
     1501 caacgaagct ccattcatta gagatgttgc aagccgaata cccaccatga atcgggccat
     1561 ggttacagtc caagtgaggg atcagaatga ggggccggaa tgcaagcccc gtgagcagat
     1621 tgtacggatc aaagagaact cagcaattgg gtctaagatc aatggctaca aggcctatga
     1681 ccccgaaacc aagaatagca atggtttaag gtacaaaaaa ttgcaggatc ctaaagactg
     1741 ggtcagcatt gaagaagttt caggatcact caccatatca aaaatcctgg acagagaaat
     1801 catggctcca agaaatgacc tatacaatat tacagtcatg gcaattgacc aagagggtag
     1861 atcatgcaca gggacgcttg cagtgaacat tgaggatatg aatgacaacg caccagagat
     1921 aattcaagat gacattgtca tctgcaagcc aaggatgggt tatacagaca tttcagctgt
     1981 ggatcctgat gaacctattc acggccctcc cttccagttc gccttggcaa gctcttctcc
     2041 agaagtcaac agaatctgga ccctcaacca agttaatgat acagctgccc gcctgtccta
     2101 tcagaaaacc gcggatgttc agatatactc cgttcctgta actgtaacag acagagcagg
     2161 ccaatctgcg accaagatct tgagagttaa cctgtgcgat tgtactcacc ccagccagtg
     2221 tctgctcaga tcaagaagag cggggatcac cctggggaag tgggcaatcc ttgccatctt
     2281 gctgggcatc gctctgctat tctcggtact gctaacttta gtatgtgggg ttgttactgc
     2341 tcaaaaagga aaacattttc ctgaagattt agcacagcaa aacttaatta tatcaaatac
     2401 cgaagcaccc ggggacgaca gagtgtgctc tgccaatgga ttcaccaccc acactgccaa
     2461 caactccagc caaggcttct gtggcacaat ggggtcagga atgaggaacg gtgggcagga
     2521 gaccatcgag atgatgaaag gccaccagac cttggactcc tgccgtgttg ctgggcatca
     2581 ccacaccctg gactcctgca ggggaggaca catggaaacc gacaactgca gatacacgta
     2641 ctcagagtgg cacagcttca ctcagccccg actcggcgaa aaattgcatg tgtgtaatca
     2701 gaacgaagac cacatcccat ctcaagacta tgtcctcacc tataactacg aaggcagggg
     2761 atctccagcc ggttctgtag gttgctgcag tgaaaagcag gaagaagagg gactcgactt
     2821 tttaaacaat ttggagccca aatttcttac attggcagaa acatgtacaa agagataa
//
LOCUS       NM_001265586             360 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed 10 (Pate10), mRNA.
ACCESSION   NM_001265586 XM_002727015 XM_002729886
VERSION     NM_001265586.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Rajesh,A. and Yenugu,S.
  TITLE     Genomic organization, tissue distribution and functional
            characterization of the rat Pate gene cluster
  JOURNAL   PLoS One 7 (3), e32633 (2012)
   PUBMED   22479333
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            HQ687477.1.
            
            On or before May 21, 2012 this sequence version replaced
            XM_002727015.1, XM_002729886.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ687477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN09345329 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..360
                     /gene="Pate10"
                     /note="prostate and testis expressed 10"
                     /db_xref="GeneID:100359924"
                     /db_xref="RGD:2323120"
     CDS             1..360
                     /gene="Pate10"
                     /note="prostate and testis expressed N; prostate and
                     testis expressed N-like"
                     /codon_start=1
                     /product="uncharacterized protein LOC100359924 precursor"
                     /protein_id="NP_001252515.1"
                     /db_xref="GeneID:100359924"
                     /db_xref="RGD:2323120"
                     /translation="MDWLLFLLFPGLLILYKSHTMGEPSFCTSCDEYVDDTCRRNLGV
                     CHPRYPDFACQTKEVYIQLNTGEYLYKYSILGCPRRCVEYVRFIKFEKNIFSCCNESY
                     CNSFQAKHTHFKENNFV"
     sig_peptide     1..66
                     /gene="Pate10"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    67..312
                     /gene="Pate10"
                     /note="three-fingered protein (TFP) fold found in Ly6/uPAR
                     (LU) and snake toxin superfamily; Region: TFP; cl45932"
                     /db_xref="CDD:480272"
     misc_feature    67..312
                     /gene="Pate10"
                     /note="three-fingered protein (TFP) fold found in Ly6/uPAR
                     (LU) and snake toxin superfamily; Region: TFP; cl45932"
                     /db_xref="CDD:480272"
     exon            1..64
                     /gene="Pate10"
                     /inference="alignment:Splign:2.1.0"
     exon            65..199
                     /gene="Pate10"
                     /inference="alignment:Splign:2.1.0"
     exon            200..360
                     /gene="Pate10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactggc tcctgtttct tttgtttcca ggactactga ttttgtacaa gtctcataca
       61 atgggggaac ccagtttttg cacttcctgt gatgaatatg ttgatgatac ctgcagaaga
      121 aacttgggag tctgccatcc cagatatcct gactttgcct gccaaaccaa agaagtatat
      181 attcaactta acactggaga atatctgtac aaatattcta tattgggctg cccaagaaga
      241 tgtgtggaat acgtgcgctt catcaagttt gagaaaaaca tcttctcctg ctgcaatgaa
      301 agctactgca acagttttca agcaaaacat actcacttca aagaaaataa ttttgtctaa
//
LOCUS       NM_001108146            2709 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus zinc finger CCCH type containing 12C (Zc3h12c),
            mRNA.
ACCESSION   NM_001108146 XM_001071727 XM_236237
VERSION     NM_001108146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071727.1, XM_236237.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2709
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="zinc finger CCCH type containing 12C"
                     /db_xref="GeneID:315658"
                     /db_xref="RGD:1565078"
     exon            1..78
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2709
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /codon_start=1
                     /product="probable ribonuclease ZC3H12C"
                     /protein_id="NP_001101616.1"
                     /db_xref="GeneID:315658"
                     /db_xref="RGD:1565078"
                     /translation="MAAEKTLQEYGVLCIQEYRKSSKVESSARNSFMGLKDHLGHDLG
                     HLYMESADPQISAAVPWPMAEKPTMDTVSAGKEEKGVSEENVSSGDSEESTNSDHESE
                     QLSSLSVEPCLLTKTHRQLCRSPCLEPHLLKHSDVLQDFKPEESQTPSKEVKKPPDVV
                     REYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTVNS
                     AMRETSSLESQRSESPMPEIVTDDGENLRPVVIDGSNVAMSHGNKEVFSCRGIKLAVD
                     WFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVC
                     YDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPL
                     GRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRA
                     MSRNTAAKTTNEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTHVYQDIEEKL
                     PTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMA
                     TKNHGAPMPYEQYPKCESPVDVGYYSMLNAYSNLSISGPRSPERRFSLDTDYRVNSVA
                     SDCSSEGSMSCGSSDSYVGYSDRSYVSSPDPQLEENLKGQHMHPHSRLNSQPFLQSFH
                     DPLTRVQSYSHEEPKFHHKRPLPHLAMHLQHPAVGARSSCPGDYPSPPSSAHSKASHL
                     GRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWDRPSYGMDAYGYRQTYSLPD
                     NSTPPCYESITFQSLPEQQEPTWRIPYCGMPHDPPRYQDSREKIYINLCNIFPPDLVR
                     LVMKRNPHMTDAQQLAAAILVEKSQLGY"
     misc_feature    541..666
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="UBA-like domain; Region: UBA_6; pfam18039"
                     /db_xref="CDD:407876"
     misc_feature    541..666
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="UBA-like domain; Region: UBA_6; pfam18039"
                     /db_xref="CDD:407876"
     misc_feature    799..1191
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="PRORP-like PIN domain of ribonuclease Zc3h12a and
                     related proteins; Region: PIN_Zc3h12-like; cd18729"
                     /db_xref="CDD:350296"
     misc_feature    799..1191
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="PRORP-like PIN domain of ribonuclease Zc3h12a and
                     related proteins; Region: PIN_Zc3h12-like; cd18729"
                     /db_xref="CDD:350296"
     misc_feature    1300..1356
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="RNA-binding, Nab2-type zinc finger; Region:
                     zf-CCCH_2; pfam14608"
                     /db_xref="CDD:464217"
     misc_feature    1300..1356
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="RNA-binding, Nab2-type zinc finger; Region:
                     zf-CCCH_2; pfam14608"
                     /db_xref="CDD:464217"
     misc_feature    2560..2691
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="Endoribonuclease Regnase 1/ ZC3H12 C-terminal
                     domain; Region: Regnase_1_C; pfam18561"
                     /db_xref="CDD:465803"
     misc_feature    2560..2691
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /note="Endoribonuclease Regnase 1/ ZC3H12 C-terminal
                     domain; Region: Regnase_1_C; pfam18561"
                     /db_xref="CDD:465803"
     exon            79..830
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
     exon            831..970
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1205
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1312
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2709
                     /gene="Zc3h12c"
                     /gene_synonym="RGD1565078"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcctg gcggaggggg cccggggccg gcccggcttc cagagcatgc cgtgatggct
       61 gcggagaaga cattgcagga atacggggtg ctttgcattc aagaatacag gaaaagcagc
      121 aaagtggagt caagtgcacg gaacagcttc atgggcttga aggatcacct ggggcatgac
      181 cttggccacc tttatatgga gagcgctgac ccacagataa gtgcagctgt gccttggccc
      241 atggcagaga aaccaacaat ggatacagtc agtgcaggga aggaagaaaa gggggtgtct
      301 gaagagaacg tgagctctgg tgactctgag gaaagcacga attctgatca tgagtcagaa
      361 caactgagta gcctttcggt agagccatgc ttattaacca agactcacag acaattgtgt
      421 cggtctccct gcttagaacc tcacctactg aaacacagtg atgttttgca agactttaaa
      481 ccagaagagt cccagactcc atccaaggaa gtgaagaaac cccctgatgt ggttcgagaa
      541 taccaaacaa aactggagtt tgcacttaag ttaggttatt ctgaagaaca ggtccagctt
      601 gtgctaaaca aacttggtac tgatgcttta atcaatgata tattgggaga acttgtcaaa
      661 cttggaaata aaagtgaagc tgatcaaaca gttagtactg ttaacagtgc gatgcgagaa
      721 acatcgtccc tggagtctca gaggtctgaa tcgccaatgc cagagatcgt gacagatgat
      781 ggtgaaaatc tgaggccagt agttattgat ggcagcaatg tggcaatgag ccatggaaac
      841 aaagaagtgt tctcatgccg aggaataaaa ttggcagtgg attggttttt ggaaagaggc
      901 cacaaagata tcacggtctt tgttccagct tggagaaaag aacagtcgcg acctgacgcc
      961 cttatcacag atcaggaaat tttacgtaaa ctagagaagg aaaaaatcct ggtgttcaca
     1021 ccatcacggc gtgtccaggg caggcgcgtg gtgtgctatg acgacaggtt catcgtgaag
     1081 ctggcttttg aatccgatgg tataattgtg tccaatgata actacagaga tctggcaaat
     1141 gaaaagccag aatggaagaa gttcatagat gaacggctat tgatgtactc cttcgtcaat
     1201 gacaagttca tgcccccaga tgacccactt ggcagacatg gcccaagtct ggataatttt
     1261 ctgaggaaga agcccattgt tcctgaacac aaaaagcagc cctgtcccta tggaaagaag
     1321 tgtacgtatg gacacaagtg caaatattac cacccagaaa ggggcagcca gcctcagcgc
     1381 tcagtggctg atgaacttcg tgccatgtct agaaacacag cagccaaaac tacaaatgaa
     1441 gggggactgg tgaagagcaa cagtgttcct tgcagcacca aggctgatag cacttcggat
     1501 gttaaacgag gtgctccaaa gaggcagtca gacccaagca taaggactca cgtctaccaa
     1561 gacatagagg aaaagcttcc caccaaaaac aagttggaaa ccaggtctgt accttcctta
     1621 gttagtatcc cggccacttc tactgcaaaa ccccaaagca ctacatcttt aagcaatggc
     1681 cttccatctg gagttcattt cccacctcag gatcaaagac cacagggaca ataccctcca
     1741 atgatgatgg caaccaaaaa tcatggcgcg ccaatgcctt acgaacagta tccaaaatgt
     1801 gagtcccctg ttgatgttgg ctattattcc atgttgaacg catattctaa tctgagtatc
     1861 tcaggccccc gaagtcctga aaggcgtttc tccctagaca ctgattatag agtcaattct
     1921 gtagcttcag actgcagcag tgaggggagc atgagctgtg ggagcagcga ctcctacgtg
     1981 gggtacagtg accgctccta cgtcagctct cctgacccac agctggaaga gaatctcaag
     2041 ggtcaacaca tgcaccctca cagccgcctt aactcccagc ccttcctgca gagtttccac
     2101 gatcccttaa ccagagttca gagttacagt cacgaagaac caaagttcca tcacaagcgt
     2161 cctcttccac acttggctat gcatctgcag caccctgccg tgggtgcccg ctccagctgt
     2221 cctggcgact acccctctcc accaagttca gcacactcta aggcatcaca cctagggagg
     2281 tccttagtgg ccacgagaat agacagcatt tctgactctc gactctatga tagttctcct
     2341 tcaagacaaa gaaagcctta ttctcgccag gaaggcctag gaagctggga taggccaagc
     2401 tatgggatgg acgcgtatgg ctaccggcag acttactcct tacccgacaa ttccacaccc
     2461 ccctgctatg agtcgatcac cttccagagc ctgcccgagc agcaggagcc gacctggagg
     2521 atcccttact gcggaatgcc acacgaccct ccgaggtacc aggacagccg agagaagatt
     2581 tatatcaact tgtgcaacat cttcccccct gaccttgtga ggctcgtcat gaagaggaat
     2641 cctcacatga cagatgccca gcagctcgcg gcagccatct tagtggagaa gtcgcagctg
     2701 ggttactga
//
LOCUS       NM_001109627            1521 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus elongin BC and polycomb repressive complex 2
            associated protein (Epop), mRNA.
ACCESSION   NM_001109627 XM_001077023
VERSION     NM_001109627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Liefke,R., Karwacki-Neisius,V. and Shi,Y.
  TITLE     EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin
            Landscape
  JOURNAL   Mol Cell 64 (4), 659-672 (2016)
   PUBMED   27863226
  REMARK    Erratum:[Mol Cell. 2017 Jan 5;65(1):202. doi:
            10.1016/j.molcel.2016.12.006. PMID: 28061330]
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   De Cegli,R., Iacobacci,S., Flore,G., Gambardella,G., Mao,L.,
            Cutillo,L., Lauria,M., Klose,J., Illingworth,E., Banfi,S. and di
            Bernardo,D.
  TITLE     Reverse engineering a mouse embryonic stem cell-specific
            transcriptional network reveals a new modulator of neuronal
            differentiation
  JOURNAL   Nucleic Acids Res 41 (2), 711-726 (2013)
   PUBMED   23180766
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001077023.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1521
                     /gene="Epop"
                     /note="elongin BC and polycomb repressive complex 2
                     associated protein"
                     /db_xref="GeneID:691153"
                     /db_xref="RGD:1587434"
     exon            1..1521
                     /gene="Epop"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    283..285
                     /gene="Epop"
                     /note="upstream in-frame stop codon"
     CDS             406..1521
                     /gene="Epop"
                     /note="uncharacterized protein C17orf96 homolog"
                     /codon_start=1
                     /product="elongin BC and Polycomb repressive complex
                     2-associated protein"
                     /protein_id="NP_001103097.1"
                     /db_xref="GeneID:691153"
                     /db_xref="RGD:1587434"
                     /translation="METLCPPPRLAVPASPRGSPCSPTPRKPRRGTPEFSPLCLRALA
                     FCALAKPRPSSLGLGPGELAPRTPVLLGSRASPCTGGWAADGLKHLGAQAGRPSDVSS
                     ATREDADVAVCPDRGEEEEGGGGFPHFGSGSCTPPGRCPAGPRESPTSPARSPPRPAR
                     GLESQLDAASSPPLGSSSRPPSPPAGLSPEPAPTEQPMRDSEAPEGGDPARVAPEAPA
                     LSPSTADATPDAPGDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGA
                     AKKRRRPAPPPRSVQPRRPAPTLPTSSTFHLLDCFPCPPALVVEENGDLGPASSLRLQ
                     GDAKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL"
     misc_feature    <541..1116
                     /gene="Epop"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <541..1116
                     /gene="Epop"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <1294..1491
                     /gene="Epop"
                     /note="Elongin BC and Polycomb repressive complex
                     2-associated protein; Region: EPOP; pfam15223"
                     /db_xref="CDD:434546"
     misc_feature    <1294..1491
                     /gene="Epop"
                     /note="Elongin BC and Polycomb repressive complex
                     2-associated protein; Region: EPOP; pfam15223"
                     /db_xref="CDD:434546"
ORIGIN      
        1 ggcggaaggc gccctccccg ccgctgggcc cgggcaccgg gcgccgggcc ggggtccttc
       61 ccgccggagg cgagcgccga ctgctttgtt tgcccccgcc ttggcgttga gaggggctcg
      121 tgctgggcgc tgcgccggga acgcggcggc aggaagcacg accgattgca ccggggacgc
      181 gcggggaccc aggagtccgg ccgcggcgag ggccgcgtga cgataccgag gagagaaccg
      241 gagagcgacc gcgggctccc ggtgctgggt ccgggacgcc agtgagcaca gacctccccg
      301 tcgacggggg gcgatgttcc cctggcccgc gggctcttcg ggccgccggg gtatcccgcc
      361 gttgggacca gggcccccgc actgggcgac ccccaaggct gctccatgga gactctgtgt
      421 cctcctcccc gcctggcagt acccgcctcc ccgagggggt ctccctgctc gcctacgccc
      481 cggaagccgc gtcgggggac cccagagttc tccccactat gcctgcgtgc cctcgccttc
      541 tgcgcccttg ccaaaccccg gccgtcctcc ctgggcctgg ggcctggaga gctggcgccg
      601 cggaccccgg tgctgctggg ctcccgggcc tcgccatgca caggcggctg ggccgcggac
      661 ggcctgaagc acctcggggc acaggccggg cggccgagcg acgtgagctc cgcgacccgc
      721 gaggatgcag acgtcgcggt gtgccccgac cgtggagagg aggaagaggg cggaggcggc
      781 ttcccgcact tcggctctgg ttcctgcaca cctccgggcc gctgccctgc tggtcctcgg
      841 gaatctccga ccagccccgc ccggtccccg cccaggccag ctaggggtct ggagtcccag
      901 cttgatgcag ctagcagtcc gccccttggg tccagctccc ggcctccgtc accacctgcg
      961 ggcctctccc cggagcctgc gcctacagag cagcctatgc gggactccga ggctccagag
     1021 ggtggagacc ctgcgcgggt cgcgcctgag gcacccgcgc tcagcccctc gacggcagac
     1081 gcaacgccgg acgcgcccgg cgatctccgc caggaacatt tcaatcgtct gatccgccgt
     1141 tcgaaacttt ggtgttacgc gaaagggttc gccctggaca ctccaagttt gcgccgaggt
     1201 cccgaacggc cggcagccaa agctcgggga gcagccaaga aacgccggcg gccagcgccg
     1261 cccccgcgca gtgtacagcc acggcgaccg gccccgacgc ttcccacctc gagcaccttc
     1321 cacctcctcg actgctttcc ctgtccccca gccctggtgg tggaagagaa cggagactta
     1381 gggccggctt cctcgcttcg cctccaggga gacgcaaagc cgccgcctgc ccacccgctg
     1441 tggaagtggc agatgggagg acccgctgtc cctgagcccc cgggcctcaa atcctggtgg
     1501 gtcaacttgg aagaactctg a
//
LOCUS       NM_001163607            5076 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus WNK lysine deficient protein kinase 3 (Wnk3),
            transcript variant 2, mRNA.
ACCESSION   NM_001163607 XR_008488
VERSION     NM_001163607.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5076)
  AUTHORS   Zhu,J., Lin,X., Chen,C., Tan,H., Gao,Y., Li,D. and Chen,G.
  TITLE     WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in
            Rats
  JOURNAL   Neuroscience 477, 76-88 (2021)
   PUBMED   34626749
  REMARK    GeneRIF: WNK3 Promotes Neuronal Survival after Traumatic Brain
            Injury in Rats.
REFERENCE   2  (bases 1 to 5076)
  AUTHORS   Wu,D., Lai,N., Deng,R., Liang,T., Pan,P., Yuan,G., Li,X., Li,H.,
            Shen,H., Wang,Z. and Chen,G.
  TITLE     Activated WNK3 induced by intracerebral hemorrhage deteriorates
            brain injury maybe via WNK3/SPAK/NKCC1 pathway
  JOURNAL   Exp Neurol 332, 113386 (2020)
   PUBMED   32589890
  REMARK    GeneRIF: Activated WNK3 induced by intracerebral hemorrhage
            deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
REFERENCE   3  (bases 1 to 5076)
  AUTHORS   Zhang,J., Gao,G., Begum,G., Wang,J., Khanna,A.R., Shmukler,B.E.,
            Daubner,G.M., de Los Heros,P., Davies,P., Varghese,J.,
            Bhuiyan,M.I., Duan,J., Zhang,J., Duran,D., Alper,S.L., Sun,D.,
            Elledge,S.J., Alessi,D.R. and Kahle,K.T.
  TITLE     Functional kinomics establishes a critical node of volume-sensitive
            cation-Cl- cotransporter regulation in the mammalian brain
  JOURNAL   Sci Rep 6, 35986 (2016)
   PUBMED   27782176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5076)
  AUTHORS   Zhang,Z., Xu,X., Xiang,Z., Yu,Z., Feng,J. and He,C.
  TITLE     LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3
            kinase activity
  JOURNAL   J Biol Chem 288 (17), 12152-12160 (2013)
   PUBMED   23482566
  REMARK    GeneRIF: LINGO-1 potentiates neuronal apoptosis, likely by
            inhibiting WNK3 kinase activity.
REFERENCE   5  (bases 1 to 5076)
  AUTHORS   Cruz-Rangel,S., Melo,Z., Vazquez,N., Meade,P., Bobadilla,N.A.,
            Pasantes-Morales,H., Gamba,G. and Mercado,A.
  TITLE     Similar effects of all WNK3 variants on SLC12 cotransporters
  JOURNAL   Am J Physiol Cell Physiol 301 (3), C601-C608 (2011)
   PUBMED   21613606
REFERENCE   6  (bases 1 to 5076)
  AUTHORS   Yang,C.L., Zhu,X. and Ellison,D.H.
  TITLE     The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK
            kinase signaling complex
  JOURNAL   J Clin Invest 117 (11), 3403-3411 (2007)
   PUBMED   17975670
REFERENCE   7  (bases 1 to 5076)
  AUTHORS   Dorwart,M.R., Shcheynikov,N., Wang,Y., Stippec,S. and Muallem,S.
  TITLE     SLC26A9 is a Cl(-) channel regulated by the WNK kinases
  JOURNAL   J Physiol 584 (Pt 1), 333-345 (2007)
   PUBMED   17673510
REFERENCE   8  (bases 1 to 5076)
  AUTHORS   Verissimo,F., Silva,E., Morris,J.D., Pepperkok,R. and Jordan,P.
  TITLE     Protein kinase WNK3 increases cell survival in a
            caspase-3-dependent pathway
  JOURNAL   Oncogene 25 (30), 4172-4182 (2006)
   PUBMED   16501604
REFERENCE   9  (bases 1 to 5076)
  AUTHORS   Rinehart,J., Kahle,K.T., de Los Heros,P., Vazquez,N., Meade,P.,
            Wilson,F.H., Hebert,S.C., Gimenez,I., Gamba,G. and Lifton,R.P.
  TITLE     WNK3 kinase is a positive regulator of NKCC2 and NCC, renal
            cation-Cl- cotransporters required for normal blood pressure
            homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 102 (46), 16777-16782 (2005)
   PUBMED   16275913
REFERENCE   10 (bases 1 to 5076)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474063.2.
            
            On Jul 26, 2009 this sequence version replaced XR_008488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5076
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..5076
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="WNK lysine deficient protein kinase 3"
                     /db_xref="GeneID:317420"
                     /db_xref="RGD:1563131"
     CDS             1..5076
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase WNK3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase WNK3 isoform 2"
                     /protein_id="NP_001157079.1"
                     /db_xref="GeneID:317420"
                     /db_xref="RGD:1563131"
                     /translation="MATDSGEPASTEDSEKPDGVSFQSRVARAVAPLTVEARIKEKYS
                     TFSASGETIERKRFFRKSVEMTEDDKVAQSSRRDERKVATNISRVEKVPTNVLRGGQE
                     VKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTV
                     YKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKG
                     KKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLK
                     CDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFG
                     MCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSER
                     LSIKDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFS
                     FNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREKKPAGCLEERRDS
                     QCKHARNVNPQQQTATLRPAPGPHNAAECEETEVDQHVRQQLVQGKAQQQPSSVRGDT
                     SSEPAAGPVLHSDTSSHPTVAYSSNQATSSQEQPKLTRSPVLPVVQGQSSVMPIYAAG
                     PAVASQSQISPLTIQKVSQIKPVSQPIGAEQQATPPNPDFVRSLNQDVTSVKENTNSP
                     DTPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSVSGDNMVECQLETHNNKMVTFK
                     FDVDGDAPEDIADYMTGSSEQVLINSASTQTSNESAPQSSPVGRWRFCINQTIKNREA
                     QSPPSLQPSVAMVPGLHPFPNNTSNQEISQDTLFTVPGHHVVFTSKLDGKIGERASVE
                     TEQTSVPYQAEDDKLKAPATDTSNYSATLVCPDPAGCEALTSQAGMFIPTYPCQQAAV
                     PADVLMSHPGESVQIGSNAVVTSVLVSSDQKPQSLSVQQPTIDAEFISQEGETTVNSE
                     TSSPKAVGATQTPGFEPTVLLPATILESDGERPPKMEFTDNRIKTLDEKLRNLLYQEH
                     SISTICPESQKDTQSIDSPFSSSAEDILSSPMPEVIAISHCGIQDSQAQSPNFQPTGS
                     KILSNVAASQPAHIPVLKRDLNVITSVPSELCLHEMSPDASLPGDPEAYPAAVSSDGT
                     IHLQTGGGYFGLSFTCPSLKNPISRKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETED
                     KRSAIASDPIPLTREFSADTRALSRCKAMSGSFQRGRFQVITVPQQQPVKMMSFGKEH
                     RPPSKKTTAQSNEQALTFTEAAVTQLIEVEPAIPTHKASVSSQKLRTLYETFKEDKGD
                     PEQGDILSLSTARETSVSSVTTEKNVEETSTTGISVQSGSEMLDKEKDESTPGKQTCT
                     NEFSATPAGSGKSVAKAAPKSGQHLPARAQTQSSLFYSPSSPMSSDNESEIEDEDLKA
                     ELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDSKAQSSEVPMPPASPRRPRSFK
                     SKLRSRPQSLTHSDNLVVVKDVQRAESNTAPRQQSPASKKGMFTDDLHKLVDDWTRET
                     VGNFPSKPSLNQLKQSQQKSEAENWNKLHESTPSTVGYTSTWISSLSQIRGAAPSSLP
                     HGLPLPSFPGPLASYGMPHACQYNPVGAASYPVQWVGISGAAQQSVVLPTQSGGLFQP
                     GMNLQSFPAPPVQNPPSIPPGPK"
     misc_feature    403..1227
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, With No Lysine (WNK) 3; Region: STKc_WNK3;
                     cd14031"
                     /db_xref="CDD:270933"
     misc_feature    403..1227
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, With No Lysine (WNK) 3; Region: STKc_WNK3;
                     cd14031"
                     /db_xref="CDD:270933"
     misc_feature    order(454..468,472..474,478..480,517..519,523..525,
                     616..618,676..687,697..699,703..705,820..822,826..828,
                     832..837,841..843,877..879,886..888,928..939)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="active site"
                     /db_xref="CDD:270933"
     misc_feature    order(454..468,472..474,478..480,517..519,523..525,
                     616..618,676..687,697..699,703..705,820..822,826..828,
                     832..837,841..843,877..879,886..888,928..939)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="active site"
                     /db_xref="CDD:270933"
     misc_feature    order(454..468,478..480,517..519,523..525,616..618,
                     676..687,697..699,820..822,826..828,832..837,841..843,
                     877..879)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270933"
     misc_feature    order(454..468,478..480,517..519,523..525,616..618,
                     676..687,697..699,820..822,826..828,832..837,841..843,
                     877..879)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270933"
     misc_feature    order(466..468,697..699,703..705,820..822,826..828,
                     832..834,886..888,928..939)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270933"
     misc_feature    order(466..468,697..699,703..705,820..822,826..828,
                     832..834,886..888,928..939)
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270933"
     misc_feature    874..939
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270933"
     misc_feature    874..939
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270933"
     misc_feature    1273..1464
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="Oxidative-stress-responsive kinase 1 C-terminal
                     domain; Region: OSR1_C; pfam12202"
                     /db_xref="CDD:463491"
     misc_feature    1273..1464
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /note="Oxidative-stress-responsive kinase 1 C-terminal
                     domain; Region: OSR1_C; pfam12202"
                     /db_xref="CDD:463491"
     exon            1..534
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            535..707
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            708..928
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1086
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1175
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1395
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1690
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1791
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1935
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2000
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2148
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2265
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2317
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2455
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..3366
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3598
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3729
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..4331
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4543
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4746
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..5076
                     /gene="Wnk3"
                     /gene_synonym="RGD1563131"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccactg attctgggga gccagctagc acagaagatt ctgagaagcc tgatggagtt
       61 tcctttcaaa gcagggttgc ccgggctgtt gcacctctga ctgtagaagc tagaataaag
      121 gaaaaataca gtaccttttc tgcttctggg gaaaccattg aaagaaagag atttttccga
      181 aagagtgttg agatgacaga agatgacaaa gttgcccaat cttcccgcag agatgaaaga
      241 aaagttgcaa caaatatttc aagagtagaa aaagttccta caaatgtgct aagaggtggg
      301 caagaagtta aatatgagca gtgttcaaag gcaacctcag aatcctcaaa agattgcttc
      361 aaggagaaaa ctgaaaagga aatggaagaa gaagcagaaa tgaaggctgt cgcaacgtcc
      421 cctagtggca ggtttctaaa atttgatata gagctgggaa gaggcgcttt taaaacagta
      481 tataaaggat tggacactga aacatgggtt gaagttgctt ggtgtgagct acaggaccgc
      541 aaattaacta aagctgagca gcaacggttc aaagaagaag ctgagatgtt gaaaggcctc
      601 cagcatccca atatagttcg attttacgat tcatgggagt ccatattgaa aggaaagaaa
      661 tgtattgttt tagtgactga actaatgaca tcaggaacct taaagacgta cttaaaacga
      721 tttaaagtca tgaaaccaaa ggtcttaaga agctggtgca ggcaaatttt aaaaggattg
      781 cagttcttac acacaaggac gcctcctatt attcaccggg atctgaaatg tgacaacatt
      841 ttcatcacag gacccactgg atctgtgaag attggtgatc tgggacttgc aaccttaatg
      901 cgcacatcct ttgctaagag tgtcattggc actcctgagt ttatggcgcc agagatgtat
      961 gaagaacact atgatgaatc tgtagatgtt tatgcttttg ggatgtgtat gttggaaatg
     1021 gctacttcgg agtatccata ttctgagtgc cagaatgcag cacaaatata ccgtaaagta
     1081 accagtggca taaaaccagc cagcttcaat aaagtcacag accctgaagt gaaagaaata
     1141 attgaaggat gtattagaca aaacaaatct gaaaggttat cgatcaagga tctactaaac
     1201 catgcattct ttgctgagga tactggactg agggtggagt tagcagagga agatgattgc
     1261 tcaaattcat ccttggctct aagactctgg gttgaagatc ctaagaaatt aaaaggcaaa
     1321 cataaagaca atgaagctat tgaattcagt ttcaacttag aagcagatac acctgaggaa
     1381 gtagcgtatg aaatggtcaa gtctggattc ttccatgaaa gtgattccaa agctgttgct
     1441 aagtccatta gggaccgtgt gacactgatt aaaaagataa gggaaaagaa gcctgctgga
     1501 tgcttagagg aacgcaggga ttcccagtgc aagcatgcga ggaatgtaaa tcctcagcag
     1561 cagactgcaa ctttacgacc tgctcctggt ccacacaatg cggctgagtg tgaagaaaca
     1621 gaagttgatc aacatgttcg acagcagctt gtacaaggca aagcacagca gcagccctcc
     1681 tctgttaggg gtgacacttc atctgaacca gcagctggac cagttctaca ttcagatact
     1741 tcaagtcacc ccactgtagc ctattcttca aaccaggcaa ctagttctca ggagcagcca
     1801 aagctgactc ggtctccagt tttgcctgtg gttcaaggtc agtcttctgt tatgcccata
     1861 tatgctgctg gacctgcagt tgcttcacag tcccagattt ctccattaac tatccagaag
     1921 gtctcacaga taaagcctgt atcccaacca attggagctg aacaacaagc aactcctcca
     1981 aatccagatt ttgttcgaag cttgaatcaa gatgtgacat ctgtgaaaga aaacaccaat
     2041 agccctgata ccccaagtgg aaatggcaaa caggatcgga tcaaacaaag aagagcctcc
     2101 tgtccccgac cagagaaggg gactaaattc cagcttactg tccttcaggt ctcagtctct
     2161 ggggacaaca tggtggaatg tcagctggaa acacataaca acaagatggt cacattcaag
     2221 tttgatgttg atggtgatgc acctgaggat atcgctgact atatgacagg atcatctgaa
     2281 caagtattga taaattctgc atccactcaa actagcaatg aatctgctcc tcagtcatcc
     2341 ccagttggtc gctggcggtt ttgtatcaac caaacaataa aaaatcgtga ggcgcagtct
     2401 cctccttccc ttcagccttc cgtggctatg gtgcctgggt tacatccatt tcctaataac
     2461 acaagtaatc aagaaatatc acaggacaca ctgttcactg ttccaggcca tcatgtagtt
     2521 ttcacctcca agttagatgg taagattggt gaacgtgcta gtgtagaaac ggagcagacg
     2581 agtgttccct atcaagcaga agatgacaaa ctaaaggcac cagctactga tacttccaat
     2641 tattctgcta ctttggtgtg tccagatcca gctggatgtg aggcactcac cagccaagca
     2701 ggcatgttca tacctacata tccatgtcag caagctgctg ttccggctga tgtgcttatg
     2761 tcccatcctg gtgaatcagt tcagattggc agtaatgctg ttgtaacgtc agtacttgta
     2821 tcttctgatc aaaagcctca atccttatca gtacagcagc caactataga tgcagagttt
     2881 atttcacaag aaggagaaac cacagtaaac tctgaaacga gttctcctaa ggctgtcggt
     2941 gccactcaga ctcctggctt tgaaccaact gtgcttctac ctgcgactat cctggaatca
     3001 gatggggaac gacctccaaa aatggagttt acagacaatc gaattaaaac actggatgaa
     3061 aaattaagaa acctgctcta tcaagagcac agcatttcta ccatctgtcc tgagagtcag
     3121 aaggatactc aaagcataga ctctccattt tcttcctctg ctgaagatat actatcctcc
     3181 ccaatgccag aagtcatagc catcagtcac tgtgggattc aagatagcca agcacaatcc
     3241 ccgaatttcc aaccaacagg ctctaagatt ctatcgaatg tggctgcaag tcagcctgct
     3301 catataccag tgctcaaaag agacctgaat gtgataactt ctgtacccag cgagctatgt
     3361 ttacacgaga tgtccccaga tgcttcactt ccaggggatc cagaggccta tcctgctgct
     3421 gtgtcaagcg atggaaccat tcatctgcag acaggaggtg gatattttgg cctaagcttt
     3481 acttgtccta gtctcaaaaa tcctattagc aggaaatcct ggactcgaaa attaaaaagc
     3541 tgggcataca ggctacggca gtcaaccagc tttttcaaga gatcaaaagt tcgtcaagtg
     3601 gaaacagaag ataaaagatc agcaattgct tctgatccca ttccgctgac acgggagttc
     3661 tcagctgata ctagggcttt gagtagatgt aaagcgatga gtggatcatt tcagcggggt
     3721 cggttccagg tgattacagt tcctcagcag cagccagtga aaatgatgtc ttttggaaaa
     3781 gaacatagac cgccatcgaa gaaaacgaca gcccagtcta acgagcaagc actaaccttt
     3841 actgaagctg cagtgacaca gttgatcgaa gtggaacctg ccatacccac tcataaagct
     3901 tcagtttctt cacaaaagtt acgaactctt tatgaaacct ttaaagaaga taaaggagac
     3961 cctgaacaag gtgacatctt atctttgagc acagctcgtg agaccagtgt gtcttcagtg
     4021 acaacagaaa agaatgtgga agaaacttct actacaggaa ttagtgtgca gtctgggtct
     4081 gaaatgttag ataaagaaaa agatgaatca actcctggga aacagacatg tactaatgaa
     4141 ttttcagcca ctcctgctgg cagtggaaag tcagtggcaa aagctgctcc aaagagtggt
     4201 cagcatttac cagcccgtgc tcaaacacag agttcactct tctactctcc atcttctcca
     4261 atgagcagtg acaatgaatc agaaatcgag gatgaggact tgaaagcgga gcttcaaaga
     4321 ttacgggaaa aacacattca agaggtggtc agtcttcaaa cacagcagaa taaagagcta
     4381 caggagctct atgaacgcct tcgagcaact aaagacagca aagcgcaatc ttcagaagtt
     4441 cccatgccac ctgcatcacc acgcaggcca agatccttca aaagcaaact tcgaagccgc
     4501 ccccagtcct tgacacattc ggacaatctc gttgttgtaa aagatgtgca gcgtgcggag
     4561 agtaatactg cgccacgcca gcaatcgcca gccagtaaga aggggatgtt cacagatgat
     4621 ttacacaagc tggtggatga ctggacaaga gaaacagtag gaaattttcc tagcaagcca
     4681 agtttaaacc aactcaaaca gagccaacaa aaatcagagg cagaaaactg gaacaagttg
     4741 catgaaagca ctccatctac tgtgggatac acatcaacct ggatttcttc tctctcccaa
     4801 attcgcggag ctgccccgtc ttccttgcca catggactcc cactcccttc atttcctggg
     4861 ccattagcgt cctatggaat gcctcatgct tgtcagtaca atcccgtagg cgccgcaagc
     4921 tatccagtac agtgggttgg gatttcggga gcagcacagc aatccgtagt gcttcctacc
     4981 caatctgggg gactcttcca gcctgggatg aatctgcagt catttccagc tccaccagtg
     5041 cagaacccac cttcaatccc tcctggtccc aaatga
//
LOCUS       NM_001107351            1083 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade
            B, member 9d (Serpinb9d), mRNA.
ACCESSION   NM_001107351 XM_001066335 XM_225267
VERSION     NM_001107351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225267.4, XM_001066335.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1083
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 9d"
                     /db_xref="GeneID:306890"
                     /db_xref="RGD:1308725"
     exon            1..117
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1083
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="serine (or cysteine) proteinase inhibitor, clade B,
                     member 9e"
                     /codon_start=1
                     /product="serine (or cysteine) peptidase inhibitor, clade
                     B, member 9d"
                     /protein_id="NP_001100821.1"
                     /db_xref="GeneID:306890"
                     /db_xref="RGD:1308725"
                     /translation="MVLLGAKGDTAVQISQALNLNKHPDEDIHKDFQLLLHNLNKPKS
                     HYCLRIANRLFAENTCKLVPTYKESCLRFYNSEIEQLSFAKAAEESRKHINTWVSKQT
                     EGKIPELLSSDSVGSETKLIMVNALYFQGSWLHCFDKEFTMEMPFKINKKETKPVQMM
                     WQEETFDVAYVKEIQAQILVMPYRGMEMSFMVLLPDEGVDIRKVESSLTFEKLTAWTK
                     PEFIYSTEVYVYLPKFQLQEQYDMTALFQHLGMIDVFSEIKADLSGMCPEKDLCVSKF
                     VHECVVEVNEEGTEAAAASAADCCYSCSEYTPTFCADRPFLFFIRHNQTNSILFCGRF
                     SSP"
     misc_feature    70..1071
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="SERine Proteinase INhibitors (serpin) family;
                     Region: serpin; cl38926"
                     /db_xref="CDD:476815"
     misc_feature    70..1071
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="SERine Proteinase INhibitors (serpin) family;
                     Region: serpin; cl38926"
                     /db_xref="CDD:476815"
     misc_feature    order(931..963,1012..1014)
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="reactive center loop (RCL); other site"
                     /db_xref="CDD:381000"
     misc_feature    order(931..963,1012..1014)
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /note="reactive center loop (RCL); other site"
                     /db_xref="CDD:381000"
     exon            118..261
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
     exon            262..379
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
     exon            380..522
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
     exon            523..678
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1083
                     /gene="Serpinb9d"
                     /gene_synonym="Serpinb9e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttgtgtc aagacaaccc ttcaaaaaat gtatgttatt ctcctgtgag catctcatct
       61 gctctagcta tggtgctctt gggggcaaag ggagacactg cagtccagat atctcaggca
      121 cttaatttaa acaaacatcc cgatgaagac atccataagg acttccagtt gcttcttcac
      181 aacctgaaca agccaaaaag ccactactgc cttagaatag ccaacaggct ctttgcagag
      241 aatacttgta aattagtccc aacctataag gagtcctgtc ttcgattcta taattcagag
      301 atagagcagc tctcctttgc caaagctgca gaggagtcaa ggaaacacat aaacacgtgg
      361 gtctccaaac agactgaagg caaaattcca gagctgttat caagtgattc agttggctca
      421 gagaccaaat tgattatggt caatgcatta tatttccaag gatcatggct tcactgcttt
      481 gataaagagt tcaccatgga aatgcccttt aaaataaaca agaaagaaac aaagccagtg
      541 cagatgatgt ggcaagaaga gacatttgac gtcgcctatg tgaaggaaat tcaagcacaa
      601 atactggtga tgccctacag agggatggaa atgagtttca tggtcctgct cccagatgag
      661 ggtgtggata tcagaaaggt ggaaagcagt ctcacttttg agaaattaac agcttggacc
      721 aaaccagagt ttatatacag cactgaggtt tatgtttacc ttccaaaatt tcaactgcaa
      781 gagcaatatg atatgacagc cctgttccag catttgggaa tgattgatgt cttcagtgag
      841 atcaaggctg acttatctgg aatgtgtcct gagaaagacc tgtgtgtgtc caagtttgtt
      901 cacgagtgtg tggtagaggt caatgaagaa ggaactgagg ctgctgcagc atctgcagct
      961 gactgttgtt acagttgtag tgaatatacc ccaactttct gtgctgatcg ccccttcctt
     1021 ttcttcatca ggcacaatca aaccaacagc atcctgttct gtggcaggtt ctcatctcca
     1081 taa
//
LOCUS       NM_001047855             966 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus deltex E3 ubiquitin ligase 4 (Dtx4), transcript
            variant 3, mRNA.
ACCESSION   NM_001047855 XM_001076321 XM_238163
VERSION     NM_001047855.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY383692.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            XM_238163.4, XM_001076321.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY383692.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..966
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="deltex E3 ubiquitin ligase 4"
                     /db_xref="GeneID:293774"
                     /db_xref="RGD:1311767"
     CDS             1..966
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     deltex 4 homolog; protein deltex-4; deltex homolog 4; E3
                     ubiquitin-protein ligase DTX4; deltex 4, E3 ubiquitin
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DTX4 isoform 3"
                     /protein_id="NP_001041320.1"
                     /db_xref="GeneID:293774"
                     /db_xref="RGD:1311767"
                     /translation="MMMMVMMMMVVVVWVPTVPVKNLNGSSPVNPALAGITGILMSAA
                     GLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQK
                     VRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNK
                     DGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEH
                     PNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWN
                     EVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD"
     misc_feature    322..522
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    322..522
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    order(331..333,340..342,424..426,430..432,439..441,
                     448..450,496..498,505..507)
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438111"
     misc_feature    order(331..333,340..342,424..426,430..432,439..441,
                     448..450,496..498,505..507)
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438111"
     misc_feature    529..933
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="Deltex C-terminal domain; Region: DTC; pfam18102"
                     /db_xref="CDD:465650"
     misc_feature    529..933
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="Deltex C-terminal domain; Region: DTC; pfam18102"
                     /db_xref="CDD:465650"
     misc_feature    order(556..570,574..576,610..612,616..618,622..630,
                     691..699,703..705,805..807,844..849,871..873)
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:193607"
     misc_feature    order(556..570,574..576,610..612,616..618,622..630,
                     691..699,703..705,805..807,844..849,871..873)
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:193607"
     exon            1..41
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            42..103
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            104..265
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            266..327
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            328..480
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            481..642
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            643..732
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
     exon            733..966
                     /gene="Dtx4"
                     /gene_synonym="LRRGT00037"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgatga tggtgatgat gatgatggtg gtggtggtat gggttcccac tgtgcctgtg
       61 aaaaacttga atgggtccag ccctgttaat cctgccttgg caggaatcac cgggatcctc
      121 atgagtgcag cgggattgcc tgtgtgtctc actcgtccac caaagttggt cctccacccg
      181 ccccctgtca gcaagagtga gataaagtcc atcccagggg tctctaacac aagccgcaag
      241 accaccaaaa aacaggctaa gaaaggtaaa accccagagg aagtgctaaa gaagtatctg
      301 cagaaggtcc ggcacccacc agaagaggat tgtaccatct gtatggagcg cctcacagcc
      361 ccctctggct acaagggccc acagcccaca gtcaagcctg acctggtagg aaagctgtcg
      421 aagtgtggcc acatctacca catctactgc ctggtggcca tgtacaacaa tgggaacaag
      481 gatggaagtt tacagtgccc aacatgtaag accatttatg gcgtgaagac aggcacccag
      541 cctccaggga agatggagta ccacctcatc ccccactcct tgcctggcca tccggattgc
      601 aagaccattc ggattatcta cagtatcccc cctggcattc agggaccaga acatccgaat
      661 cctgggaaga gcttcagcgc ccgtggcttc ccacgacatt gttaccttcc agacagcgag
      721 aaagggagaa aagttctgaa gctgcttcta gtggcctggg accgccgtct catctttgcc
      781 attggaacct ccagcaccac gggcgagtct gatactgtca tctggaatga ggtgcaccac
      841 aagacagaat ttggctctaa tctcactggc catggctacc cagatgccaa ttacctggat
      901 aacgtgctgg ctgaactggc tgcccagggt atctctgaag acagcacttc ccaggaaaaa
      961 gactga
//
LOCUS       NM_001109609            1913 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 3
            (Lingo3), mRNA.
ACCESSION   NM_001109609 XM_001075512
VERSION     NM_001109609.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001075512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577790.1, FQ087862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1913
                     /gene="Lingo3"
                     /note="leucine rich repeat and Ig domain containing 3"
                     /db_xref="GeneID:690755"
                     /db_xref="RGD:1592209"
     exon            1..97
                     /gene="Lingo3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1913
                     /gene="Lingo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1913
                     /gene="Lingo3"
                     /note="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 3
                     precursor"
                     /protein_id="NP_001103079.1"
                     /db_xref="GeneID:690755"
                     /db_xref="RGD:1592209"
                     /translation="MTCWLHMLGLHLLLLPTAPLATGCPARCECSASTRTVACGRRRL
                     TAVPEGIPAETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPR
                     LRVLRLRGNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDND
                     LVFISRRAFAGLLGLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQ
                     KLPGLLHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNL
                     SHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNLLSTLEE
                     NTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALHNL
                     PDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWVTPQHHSVTA
                     ASRGRARVLPGGTLAITDTRPQDSGTYTCVASNAGGNDTYFATLTIHPAANRTQSDGH
                     NETQVGVRFPLDLTTILVSTAMGCITFLGVVLFCFLLLFVWSRGRGQHKNNFSVEYSF
                     RKVDGPAAAAGQGGARKFNMKMI"
     sig_peptide     144..212
                     /gene="Lingo3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    210..308
                     /gene="Lingo3"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    210..308
                     /gene="Lingo3"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    243..302
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    243..302
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    306..377
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    306..377
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <309..>1190
                     /gene="Lingo3"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <309..>1190
                     /gene="Lingo3"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    378..449
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    378..449
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    450..593
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    450..593
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    594..665
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    594..665
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    666..737
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    666..737
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    738..809
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    738..809
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    810..881
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    810..881
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    882..953
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    882..953
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    954..1019
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    954..1019
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1026..1091
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1026..1091
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1098..1169
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1098..1169
                     /gene="Lingo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1134..>1358
                     /gene="Lingo3"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1134..>1358
                     /gene="Lingo3"
                     /note="polycystin cation channel protein; Region: PCC;
                     TIGR00864"
                     /db_xref="CDD:188093"
     misc_feature    1362..1610
                     /gene="Lingo3"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1362..1610
                     /gene="Lingo3"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1413..1427
                     /gene="Lingo3"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1413..1427
                     /gene="Lingo3"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1452..1466
                     /gene="Lingo3"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1452..1466
                     /gene="Lingo3"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1527..1541
                     /gene="Lingo3"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1527..1541
                     /gene="Lingo3"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1569..1586
                     /gene="Lingo3"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1569..1586
                     /gene="Lingo3"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
ORIGIN      
        1 cagagcccgg gaggtggcgg tggcggtggc ggcggctggt ggcggctggt ggctgctccg
       61 agcggccccc cgcgccgtcc aaggaggagc cgcccagctg tcctggacta tgctggcgag
      121 gccctaggcc cagaccttac accatgacct gctggctgca catgctgggc ctgcacttgc
      181 tgctgctgcc cacagcgccc ctggccacag gctgccccgc acgctgcgag tgctccgcgt
      241 ccactcgtac tgtggcctgc gggcgccgcc ggctgaccgc cgtacccgaa ggcatcccgg
      301 cagagacacg gatgctggag ctgagccgca accgcatccg ctgcctgaac cccggggacc
      361 tggcctcgct gcccaccctg gaggagctgg acctcaacca taacgtgatc gcccacgtgg
      421 aacctggggc cttcgccaac ctgccccgcc tgcgcgtcct gcgtctccgt ggcaaccagc
      481 tgaagctcat cccgccaggc gtgttcacac atctggacag cctcacgctg ctggacctga
      541 gcgagaacaa actggtcatc ctgctggatt tcagcttcca ggacctgcgc agcctgcagc
      601 ggctggaggt gggcgataac gacctggtgt tcatctcccg cagggccttc gcggggctgc
      661 tggggctggc tgagctcacg ctggagcgct gcaatctcac gtcgctgtcc ccggagtcgc
      721 tgggtcacct gcggggcttg ggcgctctgc gcctgcgcca cctggccatt gccgccctgg
      781 aggaccagaa tttccagaag cttccgggac tcttacatct ggagattgac aactggccgc
      841 tgctggagga ggtagccccg ggcagcctgc gtgggctgaa cctcacctcg ctgtccatca
      901 cgcacaccaa catcacggct gtgccggccg ccgcgctgcg acagcaggcc cacctcacgt
      961 gcctcaacct gtcgcacaac cccatcagca tggtgccacg cggctccttc agagacctgg
     1021 tgcgcctgcg cgagcttcac ctagcaggag ccctgctggc cgtcatcgag ccgcaggcct
     1081 tcgtggggct gcgacagatc cgcctgctca acctctcaga caacctgctg tccacgctgg
     1141 aggagaacac gttccactcc gtgaacacgc tcgagacgct gcgcgtggac ggcaaccctc
     1201 tggcctgcga ctgtcgcctg ctgtggatcg tgcagaggag gaagaccctg aactttgacg
     1261 gcaggctccc cgcctgcgcc acccccgccg aggtgcgcgg cgacgccttg cacaacctcc
     1321 ctgactccgt gctcttcgag tacttcgtgt gtcgcaagcc caagatccgg gagagacggc
     1381 tgcagcatgt gaccgccacc gagggtgacg acgtgcgctt tctgtgccgc gctgagggcg
     1441 agcctgcgcc cacggtggcc tgggtgacgc cccagcacca ctccgttacg gctgccagcc
     1501 ggggccgggc acgagtgctg cctgggggca ccctggccat cacagacacg cggcctcagg
     1561 acagtggcac ctacacgtgt gtggccagca acgccggggg taacgacact tatttcgcca
     1621 ccttgaccat ccatccggct gccaaccgga cccagagcga tgggcacaac gagacgcagg
     1681 tgggcgttcg gttccctctg gacctcacca ccattcttgt gtccaccgcc atggggtgca
     1741 tcaccttcct gggcgtggtc ctcttctgct ttctgctgct ctttgtgtgg agccgcggcc
     1801 gtggacagca caagaataac ttctctgtgg aatattcctt ccgcaaggtg gacggtccag
     1861 cggctgcggc tggccagggt ggcgcacgca agttcaacat gaagatgatc tga
//
LOCUS       NM_001012231             462 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ribonuclease A family member 13 (Rnase13), mRNA.
ACCESSION   NM_001012231 XM_573761
VERSION     NM_001012231.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY665836.1.
            
            On Apr 20, 2005 this sequence version replaced XM_573761.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..462
                     /gene="Rnase13"
                     /note="ribonuclease A family member 13"
                     /db_xref="GeneID:497194"
                     /db_xref="RGD:1359386"
     CDS             1..462
                     /gene="Rnase13"
                     /note="ribonuclease-like protein 13; ribonuclease 13;
                     probable inactive ribonuclease-like protein 13;
                     ribonuclease, RNase A family, 13 (non-active)"
                     /codon_start=1
                     /product="probable inactive ribonuclease-like protein 13
                     precursor"
                     /protein_id="NP_001012231.1"
                     /db_xref="GeneID:497194"
                     /db_xref="RGD:1359386"
                     /translation="MASDAASLLVLQLVLQPTLVTGITIQTAIKNFRILHVDYPMVNY
                     PKGFHGYCNGLMAYVRGKLQDWYCPKIHYVVHAPFESIQKFCKYSESFCEDYNEYCTL
                     TQNSFPITVCTLDHKQAPTSCSYNSTLTNQRLYLLCSRKHDAEPIGVIGLY"
     sig_peptide     1..66
                     /gene="Rnase13"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5GAL7.1)"
     mat_peptide     67..459
                     /gene="Rnase13"
                     /product="Probable inactive ribonuclease-like protein 13.
                     /id=PRO_0000308707"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GAL7.1)"
     misc_feature    79..435
                     /gene="Rnase13"
                     /note="Pancreatic ribonuclease; Region: RnaseA; pfam00074"
                     /db_xref="CDD:459661"
     misc_feature    79..435
                     /gene="Rnase13"
                     /note="Pancreatic ribonuclease; Region: RnaseA; pfam00074"
                     /db_xref="CDD:459661"
     misc_feature    order(208..210,304..306,337..339,382..384,388..390,
                     394..399,403..405)
                     /gene="Rnase13"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:119386"
     misc_feature    order(208..210,304..306,337..339,382..384,388..390,
                     394..399,403..405)
                     /gene="Rnase13"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:119386"
     exon            1..462
                     /gene="Rnase13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcatcag atgcggcctc gctccttgtc ctccagcttg tcttacagcc aactctggtg
       61 acaggcatca cgatacagac ggccatcaag aacttccgaa tcttacatgt cgactacccc
      121 atggttaact acccgaaggg tttccacggg tactgtaatg gcctcatggc ctacgtgaga
      181 ggcaaactcc aggactggta ctgccctaag atccactatg tggtccatgc cccctttgaa
      241 agcatccaga agttctgcaa atacagcgag agcttctgtg aggactacaa cgagtactgc
      301 accctcactc agaactcctt ccccatcact gtctgtaccc tggatcataa gcaggcccca
      361 accagctgta gctacaacag cactctgacc aaccaaaggc tgtacttgct ctgctcccgc
      421 aagcatgatg ctgaaccaat aggtgtcatc ggcctctact ag
//
LOCUS       NM_001166681             909 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 104 (Tas2r104),
            mRNA.
ACCESSION   NM_001166681
VERSION     NM_001166681.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 909)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362741.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..909
                     /gene="Tas2r104"
                     /note="taste receptor, type 2, member 104"
                     /db_xref="GeneID:100310879"
                     /db_xref="RGD:2314259"
     CDS             1..909
                     /gene="Tas2r104"
                     /note="T2R21; T2R104; taste receptor type 2 member 21"
                     /codon_start=1
                     /product="taste receptor type 2 member 104"
                     /protein_id="NP_001160153.1"
                     /db_xref="GeneID:100310879"
                     /db_xref="RGD:2314259"
                     /translation="MLSMLESILLSVATSEAMLGILGNIFIVLVNCTNWVRNKKLSKI
                     NFILTGLAISRVFTIWIITLDAYTKVFFLTTLMPSNLHECISYIWVIINHLSVWFATS
                     LSIFYFLKIANFSHYIFLWLKRRADKVFVFLIGYLIITWLASFPLAVTVIKNIKVHHN
                     NTSWLIQLEKRELLINYVFANMGPISLFMVAVFTCFLLTISLWRHRRRMQSTGSKFRD
                     LNTEVHVKAMKVLISFIILFILYFMGVLIETLCLFLTENILLFIFGFTLSSTYPCCHS
                     FILILTSRELKQASMRALQRLKCCET"
     misc_feature    19..873
                     /gene="Tas2r104"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    19..873
                     /gene="Tas2r104"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r104"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r104"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..84
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    130..192
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r104"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    133..207
                     /gene="Tas2r104"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r104"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r104"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    262..324
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    391..441
                     /gene="Tas2r104"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    391..441
                     /gene="Tas2r104"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    478..480
                     /gene="Tas2r104"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES9.1); glycosylation site"
     misc_feature    481..483
                     /gene="Tas2r104"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES9.1); glycosylation site"
     misc_feature    517..588
                     /gene="Tas2r104"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    517..588
                     /gene="Tas2r104"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    547..609
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    661..738
                     /gene="Tas2r104"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    661..738
                     /gene="Tas2r104"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    700..762
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     misc_feature    772..849
                     /gene="Tas2r104"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    772..849
                     /gene="Tas2r104"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    772..834
                     /gene="Tas2r104"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES9.1);
                     transmembrane region"
     exon            1..909
                     /gene="Tas2r104"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctaagta tgctggaaag catcctcctt tctgttgcca ctagtgaagc tatgctgggt
       61 attttaggga atatatttat tgtacttgta aactgtacaa actgggtcag gaataagaaa
      121 ctctccaaga ttaactttat tctcactggc ttggcaattt ccagggtttt taccatatgg
      181 ataataactt tagatgcata tacaaaggtt ttctttctga ctacgcttat gcctagcaat
      241 ctacatgaat gcattagtta catatgggta attattaacc acctgagtgt ctggtttgcc
      301 acaagcctca gcatctttta tttcctgaag atagcaaact tttcccacta catatttctc
      361 tggttgaaga gaagagctga taaagttttt gtctttctaa ttggatactt aattataaca
      421 tggctagctt cctttccact agctgtgaca gtgattaaaa atattaaagt gcatcataac
      481 aacacatctt ggctgatcca actggagaag agagagttac ttataaacta tgtttttgcc
      541 aatatggggc ccatttccct ctttatggtg gccgtattta cttgtttcct gttaaccatt
      601 tccctttgga gacacagaag gaggatgcaa tccactggat caaaattcag agatctcaac
      661 acagaagttc acgtgaaagc catgaaagtt ttaatttcat ttatcatcct ctttatctta
      721 tattttatgg gtgttctcat agaaacatta tgcttgtttc tcacagaaaa tatacttctc
      781 tttatttttg gcttcacttt gtcatccacg tatccctgtt gccattcctt tatcctaatt
      841 ctaacaagca gggagctgaa gcaagcctcc atgagggcac tgcagagatt aaaatgctgt
      901 gagacttaa
//
LOCUS       NM_001109490             543 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus FANCD2 opposite strand like 1 (Fancd2osl1), mRNA.
ACCESSION   NM_001109490 XM_001066250
VERSION     NM_001109490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH474014.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001066250.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..543
                     /gene="Fancd2osl1"
                     /note="FANCD2 opposite strand like 1"
                     /db_xref="GeneID:686031"
                     /db_xref="RGD:1586665"
     CDS             1..543
                     /gene="Fancd2osl1"
                     /codon_start=1
                     /product="uncharacterized protein LOC686031"
                     /protein_id="NP_001102960.1"
                     /db_xref="GeneID:686031"
                     /db_xref="RGD:1586665"
                     /translation="MAGYQLWSPWSPLDESLQWLRHTTPTFASKHPFRFSPFFPQSPC
                     DVEVQQCFHEVAVVSVMPRMIAARSSELPGHPLEPQKGTAAKKTPTIRKPQPIRLLGV
                     DSVFGRVITVQPPKWTGTFKISKTSAFSKIISKEQQWPTGLKEPQIEMTLAMCKQMLR
                     SILLLYAIYKKCTFALQHSQ"
     misc_feature    7..540
                     /gene="Fancd2osl1"
                     /note="FANCD2 opposite strand protein; Region: FANCD2OS;
                     pfam15124"
                     /db_xref="CDD:434479"
     misc_feature    7..540
                     /gene="Fancd2osl1"
                     /note="FANCD2 opposite strand protein; Region: FANCD2OS;
                     pfam15124"
                     /db_xref="CDD:434479"
     exon            1..543
                     /gene="Fancd2osl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcaggat accagctctg gtccccctgg agccccctag atgagagttt gcaatggctt
       61 cgccacacaa cacctacttt tgcttccaaa catcctttta gattctcgcc ttttttccca
      121 cagagcccct gtgatgtgga agttcaacag tgctttcacg aagtagctgt ggtctctgtg
      181 atgcccagga tgatagccgc aaggagctca gagttacctg gccacccact tgagccacag
      241 aaaggaacag cagccaagaa gacaccaacg attaggaagc cccagcccat cagactcctt
      301 ggggtggatt cagtttttgg cagggttatt acagtccagc cacccaagtg gactgggacc
      361 ttcaaaattt ctaaaacatc ggccttcagc aaaattatca gcaaagaaca acagtggccc
      421 actggactca aggagcccca gattgagatg acactggcca tgtgcaaaca gatgctacgc
      481 tccattcttc tgctgtatgc aatatacaaa aagtgcacct ttgccctgca acactcccag
      541 taa
//
LOCUS       NM_001024925            1299 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 34 (Gpr34), mRNA.
ACCESSION   NM_001024925
VERSION     NM_001024925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Kitamura,H., Makide,K., Shuto,A., Ikubo,M., Inoue,A., Suzuki,K.,
            Sato,Y., Nakamura,S., Otani,Y., Ohwada,T. and Aoki,J.
  TITLE     GPR34 is a receptor for lysophosphatidylserine with a fatty acid at
            the sn-2 position
  JOURNAL   J Biochem 151 (5), 511-518 (2012)
   PUBMED   22343749
  REMARK    GeneRIF: The present studies confirm that GPR34 is a cellular
            receptor for LysoPS, especially with a fatty acid at the sn-2
            position.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Sugo,T., Tachimoto,H., Chikatsu,T., Murakami,Y., Kikukawa,Y.,
            Sato,S., Kikuchi,K., Nagi,T., Harada,M., Ogi,K., Ebisawa,M. and
            Mori,M.
  TITLE     Identification of a lysophosphatidylserine receptor on mast cells
  JOURNAL   Biochem Biophys Res Commun 341 (4), 1078-1087 (2006)
   PUBMED   16460680
  REMARK    GeneRIF: results suggest that GPR34 is the functional mast cell
            lysophosphatidylserine receptor
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Leonoudakis,D., Conti,L.R., Radeke,C.M., McGuire,L.M. and
            Vandenberg,C.A.
  TITLE     A multiprotein trafficking complex composed of SAP97, CASK, Veli,
            and Mint1 is associated with inward rectifier Kir2 potassium
            channels
  JOURNAL   J Biol Chem 279 (18), 19051-19063 (2004)
   PUBMED   14960569
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Schulz,A. and Schoneberg,T.
  TITLE     The structural evolution of a P2Y-like G-protein-coupled receptor
  JOURNAL   J Biol Chem 278 (37), 35531-35541 (2003)
   PUBMED   12835326
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Schuh,K., Uldrijan,S., Gambaryan,S., Roethlein,N. and Neyses,L.
  TITLE     Interaction of the plasma membrane Ca2+ pump 4b/CI with the
            Ca2+/calmodulin-dependent membrane-associated kinase CASK
  JOURNAL   J Biol Chem 278 (11), 9778-9783 (2003)
   PUBMED   12511555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB159443.1.
            
            On Mar 16, 2006 this sequence version replaced NM_001024925.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB159443.1, FM092260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663598, SAMN13663601
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1299
                     /gene="Gpr34"
                     /note="G protein-coupled receptor 34"
                     /db_xref="GeneID:554353"
                     /db_xref="RGD:1563681"
     exon            1..18
                     /gene="Gpr34"
                     /inference="alignment:Splign:2.1.0"
     exon            19..84
                     /gene="Gpr34"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1299
                     /gene="Gpr34"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    142..144
                     /gene="Gpr34"
                     /note="upstream in-frame stop codon"
     CDS             178..1299
                     /gene="Gpr34"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 34"
                     /protein_id="NP_001020096.1"
                     /db_xref="GeneID:554353"
                     /db_xref="RGD:1563681"
                     /translation="MTTTVDSWLCSSPGMHFITNDSDQVSQNFSGVSNVTSCPMDEKL
                     LSTVLTTFYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFR
                     IMYHINQNRWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRRAITT
                     KQSVYVCCVVWTVALAGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFALVVM
                     FWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHA
                     FRFIYISSQLNASSCYWKEIIHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLL
                     FRRFQSDTSRSESTSEFKPGYSLHDLSVTVKMQYSTKGN"
     misc_feature    316..1167
                     /gene="Gpr34"
                     /note="putative G protein-coupled receptor 34, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPR34-like;
                     cd15148"
                     /db_xref="CDD:320276"
     misc_feature    316..1167
                     /gene="Gpr34"
                     /note="putative G protein-coupled receptor 34, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_GPR34-like;
                     cd15148"
                     /db_xref="CDD:320276"
     misc_feature    316..399
                     /gene="Gpr34"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320276"
     misc_feature    316..399
                     /gene="Gpr34"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320276"
     misc_feature    418..495
                     /gene="Gpr34"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320276"
     misc_feature    418..495
                     /gene="Gpr34"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320276"
     misc_feature    order(481..483,490..495,532..549,553..558,565..567,
                     700..702,706..720,796..798,805..813,817..825,829..834,
                     988..990,997..1002,1006..1011,1018..1020,1066..1071,
                     1075..1083,1090..1092,1099..1104)
                     /gene="Gpr34"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320276"
     misc_feature    order(481..483,490..495,532..549,553..558,565..567,
                     700..702,706..720,796..798,805..813,817..825,829..834,
                     988..990,997..1002,1006..1011,1018..1020,1066..1071,
                     1075..1083,1090..1092,1099..1104)
                     /gene="Gpr34"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320276"
     misc_feature    532..624
                     /gene="Gpr34"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320276"
     misc_feature    532..624
                     /gene="Gpr34"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320276"
     misc_feature    658..726
                     /gene="Gpr34"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320276"
     misc_feature    658..726
                     /gene="Gpr34"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320276"
     misc_feature    796..885
                     /gene="Gpr34"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320276"
     misc_feature    796..885
                     /gene="Gpr34"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320276"
     misc_feature    928..1020
                     /gene="Gpr34"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320276"
     misc_feature    928..1020
                     /gene="Gpr34"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320276"
     misc_feature    1069..1146
                     /gene="Gpr34"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320276"
     misc_feature    1069..1146
                     /gene="Gpr34"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320276"
ORIGIN      
        1 ttcagcaaag cctcaactca gttcctgtga cttctgaagt atggcctgaa tagattcaat
       61 cattattagt ccattatcat ataggaaaat ctgaagacac caagaagtat aaaaagcatg
      121 tcatttagca ccctgtcctg atagttacag aagacattga gaagttacag tgtaacaatg
      181 acgactacag ttgacagctg gctttgctcc tctcctggaa tgcactttat aactaatgac
      241 agtgaccaag tctcacaaaa tttctcagga gtgtcaaatg tcactagctg tccaatggat
      301 gaaaaattac tgtctactgt gttaacaact ttctactctg tgatattcat cgtgggactg
      361 gttggaaaca tcattgccct ttatgtattt ctgggcatcc accgcaaaag aaattccatt
      421 caaatttatc tacttaatgt ggctgttgca gaccttctac tcatcttctg cctccctttc
      481 cgcataatgt atcacatcaa ccaaaatagg tggacactag gtgtgattct ttgcaaagtt
      541 gtggggacac tattttacat gaacatgtac attagtatta ttctgcttgg gtttatcagt
      601 ttggatcgat atataaaaat caaccggtct atacaacaaa gaagggcaat aaccaccaag
      661 caaagtgttt acgtttgctg tgtagtctgg acagttgctc tagctggatt tttaacaatg
      721 atcattttga cactgaagaa gggagggcac aattccacaa tgtgtttcca ttacagagat
      781 aagcataatg caaagggaga agcgatcttt aactttgctc ttgtagtaat gttctggctc
      841 attttcctac tgataatcct ttcatatatt aagattggca agaatctact gaggatttct
      901 aaaaggaggt caaaatttcc taactctggc aaatatgcca cgacagcccg gaactccttc
      961 attgtactaa tcatttttac tatatgcttc gtgccttatc atgcctttcg attcatttac
     1021 atttcttcac agctaaatgc atcttcttgc tactggaagg aaatcattca taaaaccaat
     1081 gagatcatgt tggttctctc ctctttcaac agctgcttgg atcctgtcat gtatttccta
     1141 atgtccagta atattcgcaa aatcatgtgt caacttcttt ttagaagatt tcaaagtgac
     1201 acaagcagaa gtgaaagcac ttcagaattt aagccaggat attccttgca tgatctatct
     1261 gtgacggtca aaatgcagta cagcactaag ggtaactga
//
LOCUS       NM_022182                693 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus fibroblast growth factor 7 (Fgf7), mRNA.
ACCESSION   NM_022182 XM_346672
VERSION     NM_022182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Wang,X., Gao,Y. and Sun,X.
  TITLE     Effect of Taspine hydrochloride on the repair of rat skin wounds by
            regulating keratinocyte growth factor signal
  JOURNAL   Bioengineered 13 (1), 789-799 (2022)
   PUBMED   34898359
  REMARK    GeneRIF: Effect of Taspine hydrochloride on the repair of rat skin
            wounds by regulating keratinocyte growth factor signal.
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Zhou,L., Zhang,S., Zhang,L., Li,F., Sun,H. and Feng,J.
  TITLE     MiR-199a-3p inhibits the proliferation, migration, and invasion of
            endothelial cells and retinal pericytes of diabetic retinopathy
            rats through regulating FGF7 via EGFR/PI3K/AKT pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 19-31 (2021)
   PUBMED   32586178
  REMARK    GeneRIF: MiR-199a-3p inhibits the proliferation, migration, and
            invasion of endothelial cells and retinal pericytes of diabetic
            retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway.
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Zhang,C., Han,M. and Wu,S.
  TITLE     Silencing fibroblast growth factor 7 inhibits krypton laser-induced
            choroidal neovascularization in a rat model
  JOURNAL   J Cell Biochem 120 (8), 13792-13801 (2019)
   PUBMED   31017714
  REMARK    GeneRIF: Silencing fibroblast growth factor 7 inhibits krypton
            laser-induced choroidal neovascularization in a rat model.
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Peng,Y., Wu,S., Tang,Q., Li,S. and Peng,C.
  TITLE     KGF-1 accelerates wound contraction through the TGF-beta1/Smad
            signaling pathway in a double-paracrine manner
  JOURNAL   J Biol Chem 294 (21), 8361-8370 (2019)
   PUBMED   30894415
  REMARK    GeneRIF: findings demonstrate that KGF-1 promotes fibroblast
            contraction and accelerates wound contraction via the
            TGF-beta1/Smad signaling pathway in a double-paracrine manner.
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Zhou,C., Chen,Y., Kang,W., Lv,H., Fang,Z., Yan,F., Li,L., Zhang,W.
            and Shi,J.
  TITLE     Mir-455-3p-1 represses FGF7 expression to inhibit pulmonary
            arterial hypertension through inhibiting the RAS/ERK signaling
            pathway
  JOURNAL   J Mol Cell Cardiol 130, 23-35 (2019)
   PUBMED   30858037
  REMARK    GeneRIF: findings illustrate a role for miR-455-3p-1 in modulating
            FGF7-RAS/ERK signaling and suggest that an agomir of miR-455-3p-1
            could inhibit the proliferation of PASMCs and mitigate PAH in vivo.
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Siegfried,S., Pekonen,F., Nyman,T., Ammala,M. and Rutanen,E.M.
  TITLE     Distinct patterns of expression of keratinocyte growth factor and
            its receptor in endometrial carcinoma
  JOURNAL   Cancer 79 (6), 1166-1171 (1997)
   PUBMED   9070494
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Kitsberg,D.I. and Leder,P.
  TITLE     Keratinocyte growth factor induces mammary and prostatic
            hyperplasia and mammary adenocarcinoma in transgenic mice
  JOURNAL   Oncogene 13 (12), 2507-2515 (1996)
   PUBMED   9000125
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Yan,G., Fukabori,Y., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Heparin-binding keratinocyte growth factor is a candidate
            stromal-to-epithelial-cell andromedin
  JOURNAL   Mol Endocrinol 6 (12), 2123-2128 (1992)
   PUBMED   1491693
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Yan,G.C., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Sequence of rat keratinocyte growth factor (heparin-binding growth
            factor type 7)
  JOURNAL   In Vitro Cell Dev Biol 27A (6), 437-438 (1991)
   PUBMED   1869483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X56551.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56551.1, AF295300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="fibroblast growth factor 7"
                     /db_xref="GeneID:29348"
                     /db_xref="RGD:61805"
     exon            1..394
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    19..21
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="upstream in-frame stop codon"
     CDS             109..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="FGF-7; HBGF-7; heparin-binding growth factor 7;
                     Keratinocyte Growth Factor Fgf-7; fibroblast growth factor
                     5b"
                     /codon_start=1
                     /product="fibroblast growth factor 7 precursor"
                     /protein_id="NP_071518.1"
                     /db_xref="GeneID:29348"
                     /db_xref="RGD:61805"
                     /translation="MRKWILTRILPTPLYRPCFHLVCLVGTISLACNDMSPEQTATSV
                     NCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIMT
                     VAVGIVAIKGVESEYYLAMNKQGELYAKKECNEDCNFKELILENHYNTSASAKWTHSG
                     GEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT"
     sig_peptide     109..201
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     202..690
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /product="Fibroblast growth factor 7. /id=PRO_0000008968"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02195.1)"
     misc_feature    241..243
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q02195.1); glycosylation site"
     misc_feature    277..684
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 7 (FGF7) and similar proteins; Region:
                     beta-trefoil_FGF7; cd23319"
                     /db_xref="CDD:467005"
     misc_feature    277..684
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 7 (FGF7) and similar proteins; Region:
                     beta-trefoil_FGF7; cd23319"
                     /db_xref="CDD:467005"
     misc_feature    553..555
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q02195.1); glycosylation site"
     exon            395..498
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
     exon            499..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatctacaa ttcacagata ggaggaggcc catgacctag gagtagcgat caactcaagg
       61 tccagttctc attatgttat tcatggacac ccggggcact gctctataat gcgcaaatgg
      121 atactgacac ggatcctgcc gactccgctc tacagaccgt gcttccacct cgtctgtctt
      181 gtgggcacca tatctttagc ttgcaatgac atgagtccag agcagacggc cacgagcgtg
      241 aactgttcta gccccgagcg acacacgaga agttatgact acatggaagg aggggatata
      301 agggtgagga gactgttctg tcgcacccag tggtacctga ggattgacaa acgaggcaaa
      361 gtgaaaggga cccaggagat gaggaacagc tacaacatca tggaaatcat gactgtggca
      421 gttggaattg tggcaatcaa aggggtggaa agtgaatact atcttgccat gaacaaacaa
      481 ggggaactct atgcaaagaa agaatgcaat gaggattgca acttcaaaga actgattctg
      541 gaaaaccatt acaacacctc tgcatcagct aaatggacac acagcggagg ggaaatgttc
      601 gtggccttaa atcaaaaggg gcttcctgtc aaagggaaga aaacgaagaa agaacaaaaa
      661 acggcccact ttcttcctat ggcaataact taa
//
LOCUS       NM_001166689             930 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 113 (Tas2r113),
            mRNA.
ACCESSION   NM_001166689
VERSION     NM_001166689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362749.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..930
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="taste receptor, type 2, member 113"
                     /db_xref="GeneID:100310885"
                     /db_xref="RGD:2314255"
     CDS             1..930
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="taste receptor type 2 member 30; T2R113"
                     /codon_start=1
                     /product="taste receptor type 2 member 113"
                     /protein_id="NP_001160161.1"
                     /db_xref="GeneID:100310885"
                     /db_xref="RGD:2314255"
                     /translation="MVAVLQSTFAIIFSMEFIVGTLGNGFIILMTCIDWVRRRKISLV
                     DQILTALAITRITLILLVFIDWWVSVLFPALHETGKILRMYFISWTVINHCNLWLTAS
                     LSIIYFLKIASFSSIIFLYLKFRVKNVVFVTLLVSLFFLFINTAIVNVYFDVCFDGVQ
                     RNVSQVSRLYNHEQICKFLSFTNPMFAFIPFVTSMATFFLLIFSLWRHLKNMKHNAEG
                     CRDVSTIVHIRALQTIIVSVVLYSTFFLSFFVKVWSSGSPERYLIFLFVWALGNAVLP
                     AHTFVLIWGNCRLRWASLSLMLWLRYRFKNIDV"
     misc_feature    22..891
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    22..891
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    22..99
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    22..99
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    25..87
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    133..207
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    166..228
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    247..315
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    247..315
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    304..366
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    382..444
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    394..444
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    394..444
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    484..486
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES1.1); glycosylation site"
     misc_feature    526..597
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    526..597
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    556..618
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    670..747
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    670..747
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    688..750
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     misc_feature    781..858
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    781..858
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    787..849
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES1.1);
                     transmembrane region"
     exon            1..930
                     /gene="Tas2r113"
                     /gene_synonym="T2R30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtggccg ttctacagag cacatttgca ataattttca gtatggagtt catagtggga
       61 accttaggaa atggattcat tattctgatg acatgcatag actgggtccg aagaagaaaa
      121 atctctttag tggatcaaat cctcactgct ctggcaatta ccagaatcac tctaattttg
      181 ttggtattca tagattggtg ggtatctgtt cttttcccag cattacatga aactggtaag
      241 atattaagaa tgtattttat ctcctggact gtgatcaatc attgtaatct ttggttgaca
      301 gcaagcctga gcatcattta ttttctcaag atagccagct tttctagcat tatttttctt
      361 tatctaaagt ttagagttaa aaatgtggtt tttgtgacct tgttagtgtc tctatttttc
      421 ttgttcataa atactgctat tgtaaatgta tattttgatg tttgttttga tggtgttcaa
      481 agaaatgtgt ctcaagtttc cagattgtat aaccacgaac aaatttgcaa atttctttct
      541 tttactaacc ctatgtttgc attcataccc tttgttacgt ccatggcaac gttctttctg
      601 ctcatcttct ccctgtggag acatctgaaa aacatgaagc acaacgcaga aggatgcaga
      661 gacgtcagca ccatagtaca catcagagcc ttgcaaacca tcattgtgtc tgtagtgtta
      721 tacagtactt ttttcctgtc attttttgta aaagtttgga gttctgggtc accagagaga
      781 tacctgatct ttctgtttgt ctgggctctg ggaaatgctg ttcttcctgc tcacacgttt
      841 gtcctgattt ggggaaactg tagattgagg tgggcctctc tctccctgat gttgtggctc
      901 aggtacaggt tcaaaaatat agacgtatag
//
LOCUS       NM_001109142             714 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus regulator of G protein signaling 9 binding
            protein (Rgs9bp), mRNA.
ACCESSION   NM_001109142 XM_001079782 XM_574424
VERSION     NM_001109142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 714)
  AUTHORS   Tian,M., Zallocchi,M., Wang,W., Chen,C.K., Palczewski,K.,
            Delimont,D., Cosgrove,D. and Peng,Y.W.
  TITLE     Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod
            photoreceptors
  JOURNAL   PLoS One 8 (3), e58832 (2013)
   PUBMED   23555598
REFERENCE   2  (bases 1 to 714)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   3  (bases 1 to 714)
  AUTHORS   Keresztes,G., Martemyanov,K.A., Krispel,C.M., Mutai,H., Yoo,P.J.,
            Maison,S.F., Burns,M.E., Arshavsky,V.Y. and Heller,S.
  TITLE     Absence of the RGS9.Gbeta5 GTPase-activating complex in
            photoreceptors of the R9AP knockout mouse
  JOURNAL   J Biol Chem 279 (3), 1581-1584 (2004)
   PUBMED   14625292
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574424.2, XM_001079782.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..714
                     /gene="Rgs9bp"
                     /gene_synonym="RGD1561747"
                     /note="regulator of G protein signaling 9 binding protein"
                     /db_xref="GeneID:499132"
                     /db_xref="RGD:1561747"
     CDS             1..714
                     /gene="Rgs9bp"
                     /gene_synonym="RGD1561747"
                     /note="regulator of G-protein signalling 9 binding
                     protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 9-binding
                     protein"
                     /protein_id="NP_001102612.1"
                     /db_xref="GeneID:499132"
                     /db_xref="RGD:1561747"
                     /translation="MAREECKALLDALNKTTACYHHLVLTVGGSADTQDLREELQKTR
                     QKARELAMATGSRLTVALRDRSLATEERAEFERLWVAFSGCLDLLEADMQRALALGAA
                     FPLHAPRRPLVRTGVAGGSSAVAARALSARSLRHEAESDFDVADLPQLEREVLQVGEM
                     IDNMEMKVNVPRWTVQARQSAGAELLSGASAGASSAGGISVEERAGPCDPSRALAATV
                     FSAVLLVAVALALCVAKLS"
     misc_feature    64..>234
                     /gene="Rgs9bp"
                     /gene_synonym="RGD1561747"
                     /note="Syntaxin-like protein; Region: Syntaxin_2;
                     pfam14523"
                     /db_xref="CDD:464199"
     misc_feature    64..>234
                     /gene="Rgs9bp"
                     /gene_synonym="RGD1561747"
                     /note="Syntaxin-like protein; Region: Syntaxin_2;
                     pfam14523"
                     /db_xref="CDD:464199"
     exon            1..714
                     /gene="Rgs9bp"
                     /gene_synonym="RGD1561747"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccagag aggagtgcaa ggcgctgctg gacgcgctca ataagaccac agcgtgctac
       61 catcacttag tgcttactgt gggcggctcc gcggacacac aggacctacg cgaagaactg
      121 cagaagaccc gccagaaggc gcgggagctg gccatggcca ccggctcccg gttgaccgtc
      181 gcactccgcg accggagctt agctaccgag gagcgcgcgg agtttgagcg tctctgggtg
      241 gccttttcgg gctgcctgga cctgctcgaa gccgacatgc agcgcgcact ggcgctggga
      301 gccgccttcc cgctgcacgc gccgcgccgg ccacttgttc gcactggggt ggccggcggc
      361 tcctctgctg tagccgcgcg cgccctgagc gcccgcagcc tgcggcacga agccgagagc
      421 gacttcgacg tcgccgatct gccccagttg gagcgcgaag tcctccaggt gggcgagatg
      481 atcgacaaca tggaaatgaa agtcaacgtg ccccgctgga ctgtacaggc gcgacaatcg
      541 gcgggcgccg aactcctgtc cggtgccagt gccggagcgt cctccgcggg tggcatttct
      601 gtagaggagc gcgcgggacc ctgcgacccc agcagggccc tggctgccac cgttttcagc
      661 gccgtgctgc tggtggctgt ggccctcgcc ttatgtgtgg caaagctgag ctga
//
LOCUS       NM_001168332            1065 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, M1, gene 5 (RT1-M1-5), mRNA.
ACCESSION   NM_001168332 XM_001059138 XM_001075866
VERSION     NM_001168332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1065)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from BX883051.1.
            
            On or before Dec 3, 2009 this sequence version replaced
            XM_001075866.1, XM_001059138.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760434, SAMN14984027
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BX883051.1         90932-91004         c
            74-343              BX883051.1         90422-90691         c
            344-619             BX883051.1         89887-90162         c
            620-895             BX883051.1         89439-89714         c
            896-1065            BX883051.1         88904-89073         c
FEATURES             Location/Qualifiers
     source          1..1065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1065
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="RT1 class I, M1, gene 5"
                     /db_xref="GeneID:680842"
                     /db_xref="RGD:1587041"
     CDS             1..1065
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="histocompatibility 2, M region locus 9"
                     /codon_start=1
                     /product="RT1 class I, M1, gene 5 precursor"
                     /protein_id="NP_001161804.1"
                     /db_xref="GeneID:680842"
                     /db_xref="RGD:1587041"
                     /translation="MKTFVHQALLLLLIVTLAITGHPKGLHSLNYKQTLLEWPGFLEL
                     QFIAVIYADDIQFLGLNSIWGSSRAENKVPWMDEDEPETSEKVTQSMLDEKDLLTKIM
                     KKVLHIYNYSMTGYHTIQRRRGCYVVPGGHFSHGFVELTFNNHDYIMLNEDLETWSVV
                     GKAAEMIRQDFEEENFAKYMREYLRGPCVEGILGLLQYGEKALLRAGTPKTHVTHKVT
                     ADGKITLRCWALNFYPAEITLIWQKDGSNKTQDVEVIETRPSGDGNFQKWAAVVVPSG
                     EEQRFTCHVEHERLPKPITLRWESPQSINSTMAIAIAVVLGALLMGAVLTFFIWKRRT
                     KGKEKQSLSSWLHGNIKPNL"
     sig_peptide     1..69
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    73..609
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    73..609
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    625..894
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    625..894
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    625..645
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    625..645
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    667..696
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    667..696
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    order(676..678,682..684,763..768,772..780,796..798,
                     802..804)
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(676..678,682..684,763..768,772..780,796..798,
                     802..804)
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(697..705,787..789,862..864)
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    order(697..705,787..789,862..864)
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    709..726
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    709..726
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    733..744
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    733..744
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    754..780
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    754..780
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    787..819
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    787..819
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    838..861
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    838..861
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    880..891
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    880..891
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     exon            1..73
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="alignment:Splign:2.1.0"
     exon            74..343
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="alignment:Splign:2.1.0"
     exon            344..619
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="alignment:Splign:2.1.0"
     exon            620..895
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1065
                     /gene="RT1-M1-5"
                     /gene_synonym="H2-M9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaaacct ttgtacacca ggctctcctc ctgctgctca tcgtcactct ggctatcaca
       61 gggcatccaa agggtttaca ctctctgaat tataaacaaa ctctcctgga atggcctggc
      121 tttttggaac tacagtttat cgctgttatc tatgcggatg atatacagtt cctaggactc
      181 aacagcatat gggggagttc gagggcagag aacaaagtac catggatgga tgaggatgaa
      241 ccagagactt cagagaaagt aacacagagc atgctggatg aaaaagatct cttgacaaaa
      301 ataatgaaga aagtgctcca catatacaat tacagcatga ctggttatca cacaatccag
      361 aggaggcgtg gctgttatgt ggtgccagga gggcacttca gtcacggatt cgtagaatta
      421 accttcaata accacgatta tatcatgctg aatgaggacc tggaaacctg gagcgtggtt
      481 ggcaaggccg ctgagatgat caggcaagac tttgaggagg aaaattttgc aaaatacatg
      541 agagaatacc tgcggggtcc atgtgtggaa gggatccttg gactcctgca atatggtgag
      601 aaggccttgc tgagagcagg cactcctaaa acacatgtga cccataaggt cacagctgat
      661 gggaaaataa ccttgaggtg ctgggctttg aacttctacc ctgctgaaat caccttgatc
      721 tggcagaagg atgggagcaa caagacccag gatgtggagg tgatagagac caggccttca
      781 ggggatggaa acttccagaa gtgggcagct gtggtggtgc catctgggga agagcagaga
      841 ttcacatgtc atgtggagca tgagcgtctg cctaagccca tcaccctgag atgggagtct
      901 cctcagtcca tcaactctac catggctatt gctattgctg tggttcttgg agctctgctt
      961 atgggagcag tgttgacttt ttttatatgg aagaggagga ctaaaggtaa ggaaaagcag
     1021 agtctgagtt catggcttca tggaaatatc aagcctaatc tgtaa
//
LOCUS       NM_001009919             804 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus immunoreceptor Ly49si3 (Ly49si3), mRNA.
ACCESSION   NM_001009919
VERSION     NM_001009919.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Nylenna,O., Naper,C., Vaage,J.T., Woon,P.Y., Gauguier,D.,
            Dissen,E., Ryan,J.C. and Fossum,S.
  TITLE     The genes and gene organization of the Ly49 region of the rat
            natural killer cell gene complex
  JOURNAL   Eur J Immunol 35 (1), 261-272 (2005)
   PUBMED   15593300
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY653730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY653730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..804
                     /gene="Ly49si3"
                     /note="immunoreceptor Ly49si3"
                     /db_xref="GeneID:494209"
                     /db_xref="RGD:1359669"
     CDS             1..804
                     /gene="Ly49si3"
                     /note="T-cell surface glycoprotein YE1/48-like; killer
                     cell lectin-like receptor 7"
                     /codon_start=1
                     /product="immunoreceptor Ly49si3"
                     /protein_id="NP_001009919.1"
                     /db_xref="GeneID:494209"
                     /db_xref="RGD:1359669"
                     /translation="MSEQEVSYSNVRFQKCSDLQNQVRPEETQRARAAGHRERSVPWQ
                     LIVVALVILCSLRLVAVAMFVTNIFQYTHEKHELHETLSHKYNCTSMPNDIDLKEEML
                     RNMSINCSRGNDLLLSLKREQTRWYRESKTVIPSSQHTGKNVEIYWFCYGIKCYYFIL
                     DKKTWIRCQQACQKSRLSLLKIDDEDELKFLQLQVLSDQYWIGLSYNKAKEEWSWIDN
                     GQSEFSLNLKKYNEKYGGCMFLSQTRLENAMCMNRYPCICQKRLEKFPD"
     misc_feature    118..474
                     /gene="Ly49si3"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:462461"
     misc_feature    118..474
                     /gene="Ly49si3"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:462461"
     misc_feature    433..780
                     /gene="Ly49si3"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    433..780
                     /gene="Ly49si3"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(595..597,676..678,730..732,736..741)
                     /gene="Ly49si3"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     misc_feature    order(595..597,676..678,730..732,736..741)
                     /gene="Ly49si3"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     exon            1..112
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
     exon            113..202
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..421
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
     exon            422..564
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..668
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..804
                     /gene="Ly49si3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtgagc aggaggtgtc ttactcaaat gtgagatttc aaaaatgttc agatttgcag
       61 aaccaagtga gacctgagga gacccaaagg gccagagcag ctggccacag agagaggtca
      121 gtcccctggc agctcattgt ggtagctctt gtaatcctct gttcccttcg gctggtagct
      181 gttgcaatgt tcgtgacaaa catttttcag tatactcacg aaaaacatga actgcatgag
      241 actctaagcc acaagtataa ttgcacatcc atgccgaatg acattgactt aaaggaagaa
      301 atgctaagaa atatgtctat aaattgtagt cgaggcaatg atcttctgct atcactaaag
      361 agagaacaga caagatggta ccgtgaatct aagactgtta taccttcctc tcagcacaca
      421 ggcaaaaatg ttgaaatata ctggttctgc tatggtataa aatgttatta tttcatcctg
      481 gacaaaaaaa cctggatcag atgtcaacaa gcctgccaga aatccagatt atcccttctg
      541 aagatagatg atgaggatga gctgaagttc cttcagctcc aggttctttc agaccagtac
      601 tggattggat tgtcatacaa taaagcaaaa gaggaatggt catggattga taatggccaa
      661 tctgaatttt ccttgaacct aaaaaaatac aatgaaaagt atggaggatg tatgttctta
      721 tctcaaacaa gactagaaaa tgctatgtgc atgaaccgtt acccatgtat ttgtcagaag
      781 agacttgaga aattccctga ttga
//
LOCUS       NM_001037733            5012 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 1 (Trpm1), transcript variant 2, mRNA.
ACCESSION   NM_001037733 XM_341868
VERSION     NM_001037733.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5012)
  AUTHORS   Jirku,M., Lansky,Z., Bednarova,L., Sulc,M., Monincova,L., Majer,P.,
            Vyklicky,L., Vondrasek,J., Teisinger,J. and Bousova,K.
  TITLE     The characterization of a novel S100A1 binding site in the
            N-terminus of TRPM1
  JOURNAL   Int J Biochem Cell Biol 78, 186-193 (2016)
   PUBMED   27435061
  REMARK    GeneRIF: a molecular mechanism for the potential regulation of
            TRPM1 by S100A1
REFERENCE   2  (bases 1 to 5012)
  AUTHORS   Devi,S., Markandeya,Y., Maddodi,N., Dhingra,A., Vardi,N.,
            Balijepalli,R.C. and Setaluri,V.
  TITLE     Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium
            channel function and increases melanin content in human melanocytes
  JOURNAL   Pigment Cell Melanoma Res 26 (3), 348-356 (2013)
   PUBMED   23452348
REFERENCE   3  (bases 1 to 5012)
  AUTHORS   Thameem,F., Puppala,S., Arar,N.H., Blangero,J., Duggirala,R. and
            Abboud,H.E.
  TITLE     Genetic variants in transient receptor potential cation channel,
            subfamily M 1 (TRPM1) and their risk of albuminuria-related traits
            in Mexican Americans
  JOURNAL   Clin Chim Acta 412 (23-24), 2058-2062 (2011)
   PUBMED   21439949
REFERENCE   4  (bases 1 to 5012)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 5012)
  AUTHORS   Koike,C., Obara,T., Uriu,Y., Numata,T., Sanuki,R., Miyata,K.,
            Koyasu,T., Ueno,S., Funabiki,K., Tani,A., Ueda,H., Kondo,M.,
            Mori,Y., Tachibana,M. and Furukawa,T.
  TITLE     TRPM1 is a component of the retinal ON bipolar cell transduction
            channel in the mGluR6 cascade
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 332-337 (2010)
   PUBMED   19966281
REFERENCE   6  (bases 1 to 5012)
  AUTHORS   Morgans,C.W., Zhang,J., Jeffrey,B.G., Nelson,S.M., Burke,N.S.,
            Duvoisin,R.M. and Brown,R.L.
  TITLE     TRPM1 is required for the depolarizing light response in retinal
            ON-bipolar cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (45), 19174-19178 (2009)
   PUBMED   19861548
REFERENCE   7  (bases 1 to 5012)
  AUTHORS   Audo,I., Kohl,S., Leroy,B.P., Munier,F.L., Guillonneau,X.,
            Mohand-Said,S., Bujakowska,K., Nandrot,E.F., Lorenz,B.,
            Preising,M., Kellner,U., Renner,A.B., Bernd,A., Antonio,A.,
            Moskova-Doumanova,V., Lancelot,M.E., Poloschek,C.M., Drumare,I.,
            Defoort-Dhellemmes,S., Wissinger,B., Leveillard,T., Hamel,C.P.,
            Schorderet,D.F., De Baere,E., Berger,W., Jacobson,S.G., Zrenner,E.,
            Sahel,J.A., Bhattacharya,S.S. and Zeitz,C.
  TITLE     TRPM1 is mutated in patients with autosomal-recessive complete
            congenital stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 720-729 (2009)
   PUBMED   19896113
REFERENCE   8  (bases 1 to 5012)
  AUTHORS   van Genderen,M.M., Bijveld,M.M., Claassen,Y.B., Florijn,R.J.,
            Pearring,J.N., Meire,F.M., McCall,M.A., Riemslag,F.C., Gregg,R.G.,
            Bergen,A.A. and Kamermans,M.
  TITLE     Mutations in TRPM1 are a common cause of complete congenital
            stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 730-736 (2009)
   PUBMED   19896109
REFERENCE   9  (bases 1 to 5012)
  AUTHORS   Li,Z., Sergouniotis,P.I., Michaelides,M., Mackay,D.S., Wright,G.A.,
            Devery,S., Moore,A.T., Holder,G.E., Robson,A.G. and Webster,A.R.
  TITLE     Recessive mutations of the gene TRPM1 abrogate ON bipolar cell
            function and cause complete congenital stationary night blindness
            in humans
  JOURNAL   Am J Hum Genet 85 (5), 711-719 (2009)
   PUBMED   19878917
REFERENCE   10 (bases 1 to 5012)
  AUTHORS   Wang,H.P., Pu,X.Y. and Wang,X.H.
  TITLE     Distribution profiles of transient receptor potential
            melastatin-related and vanilloid-related channels in prostatic
            tissue in rat
  JOURNAL   Asian J Androl 9 (5), 634-640 (2007)
   PUBMED   17712480
  REMARK    GeneRIF: Polymerase chain reaction used to check the expression of
            all TRPM and TRPV channel members with specific primers.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ867483.1.
            
            On Dec 15, 2005 this sequence version replaced XM_341868.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ867483.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5012
                     /gene="Trpm1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
     exon            1..218
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Trpm1"
                     /note="upstream in-frame stop codon"
     CDS             144..5012
                     /gene="Trpm1"
                     /function="putative ion channel protein"
                     /note="isoform 2 is encoded by transcript variant 2;
                     melastatin; melastatin-1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 1 isoform 2"
                     /protein_id="NP_001032822.1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
                     /translation="MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVI
                     PSTKDPNRCCCGQLTNQHIPPLPSVTPSSTAEDTKQGDAQSGKWSVSKHTQSYPTDSY
                     GILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQP
                     KLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWG
                     MVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQL
                     EKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLREDPPVPVVVCDGSGRASDI
                     LSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSHQLFAIIMECMKKKELVTVFR
                     MGSEGQQDVEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL
                     APPVDTKVAEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQ
                     AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSN
                     LPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDE
                     PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE
                     CMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVA
                     MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIM
                     GILIPPTILFLEFRSYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQ
                     RSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIV
                     SLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQNQPYMGYG
                     RVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQ
                     AILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLP
                     PCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF
                     HDRPVLPPPMIILSHIYIIVMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFE
                     EQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKASLQTVDLRL
                     SQLEELSGRMVGALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSMYRY
                     HFNGEELLFEEPALSTSPGTVFRKKTCSFRVKEEDVKPHLDQPSSLHHTPGPSPPATP
                     GRSRLALDGPLSTELRPGLDPGISAGELDPRADFKSAEVAPSLNTANVASTQLTVEST
                     VSHPLRESKLARYYPGDLNTYKTMKSRSFVYSEGRKLVRGLSNWGAEYSSIMDQTWNS
                     AEWRCQVQRITRSRSTDIPYIVSEAASQDEFEDEHRESLLAPQISRSALTVSDRPEKE
                     NLLSVKPHQTLGFPCLRSRSLHGHPRSAKPSPSKLDRAGHASSTSNLAVMSDAPEGQN
                     TQQEKGNPETEC"
     misc_feature    144..218
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    336..419
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    489..1286
                     /gene="Trpm1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; pfam18139"
                     /db_xref="CDD:465665"
     misc_feature    489..1286
                     /gene="Trpm1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; pfam18139"
                     /db_xref="CDD:465665"
     misc_feature    1494..1613
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1995..2066
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <2412..3608
                     /gene="Trpm1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    <2412..3608
                     /gene="Trpm1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    2607..2711
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2769..2831
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    2970..3032
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3063..3125
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3162..3224
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3441..3503
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3504..3506
                     /gene="Trpm1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q2WEA5.2); glycosylation site"
     misc_feature    3594..3656
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     transmembrane region"
     misc_feature    3813..3980
                     /gene="Trpm1"
                     /note="tetramerization domain of TRPM; Region: TRPM_tetra;
                     pfam16519"
                     /db_xref="CDD:465156"
     misc_feature    3813..3980
                     /gene="Trpm1"
                     /note="tetramerization domain of TRPM; Region: TRPM_tetra;
                     pfam16519"
                     /db_xref="CDD:465156"
     misc_feature    4203..4361
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4842..5009
                     /gene="Trpm1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2WEA5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            219..298
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..494
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..708
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..833
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1005
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1180
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1304
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1377
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1478
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1649
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1784
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1835
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1976
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2006
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2299
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2528
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2651
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2783
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2912
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3164
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3339
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3360
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3505
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3708
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3841
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..5012
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttctgag ctgactgagc caccaatatc acccccgaac tctgagccct gctgtccagc
       61 ctggtaaaga gaactctctt gcctcagcct attggagact cccatgcagc aggctgggcc
      121 tcacagggaa tgcagaagca ccaatggggt ccatgaggaa aatgagcagc tccttcaagc
      181 gtggttcaat caagagctcc acatcagggt cccagaaggg tcagaaagca tggatagaga
      241 agacgttttg caaaagggaa tgcatcttcg tgattcctag tacaaaagac ccgaacagat
      301 gttgctgtgg tcagctcact aaccagcaca tccccccgct gccgagtgtg actcccagct
      361 caacagcaga ggacaccaag caaggggacg cacagtccgg gaaatggtct gtcagcaaac
      421 acacccagag ctacccaaca gactcctatg ggattcttga attccagggt gggggctact
      481 ccaataaagc catgtatatc cgagtctcct acgacaccaa gccagattct ctgctccatc
      541 tcatggtgaa ggactggcag ctggagctcc ccaagctctt gatatctgtg catggaggcc
      601 tccagagctt tgagatgcag cccaagctga agcaggtctt tgggaaaggt ctgatcaagg
      661 ctgccatgac cacaggggca tggatcttca ccgggggagt gagcactggt gtcgtcagcc
      721 atgtggggga tgccttgaag gaccactcct ccaagtccag aggccggctc tgtgctatcg
      781 gaatcgctcc ctggggcatg gtggagaaca aggaagatct ggttgggaaa gatgtaacga
      841 gagtctacca gaccatgtcc aaccctctga gcaagctctc cgtgctcaac aattctcaca
      901 ctcacttcat cttggctgac aatggcaccc ttggcaagta tggtgccgag gtgaagcttc
      961 gaagacaact ggaaaaacac atctccctgc agaagatcaa cacgaggctg ggccagggtg
     1021 tacctgtcgt gggtctcgtg gtggaaggtg gacctaatgt ggtttctatc gtcctggagt
     1081 atctcagaga agaccctcct gtccctgtgg tggtttgtga cggcagtgga cgcgcctccg
     1141 acattttgtc ttttgcacac aaatactgcg acgaaggagg ggtcataaac gagtccctgc
     1201 gggaccagct tctagttacc attcagaaaa catttaatta cagcaagtcc cagtcgcatc
     1261 agctgtttgc aattatcatg gagtgcatga agaagaaaga actcgtcact gtgtttcgga
     1321 tgggctctga gggtcagcaa gatgttgaga tggcaatttt aactgccttg ctcaaaggaa
     1381 ccaacgtgtc agctccagat cagctgagct tggcactggc ttggaaccgc gtggacatag
     1441 cacgaagcca gatcttcgtc tttggcccac actggccgcc actgggaagc ctggcccctc
     1501 ctgtggacac caaagtcgca gagaaggaga agaagccacc cacagccacc accaagggaa
     1561 gaggaaaagg gaaaggcaag aagaaaggca aagtgaaaga ggaggtggag gaagaaacag
     1621 acccccggaa gatcgagctg ctgaactggg tgaacgccct ggagcaagcc atgctggacg
     1681 ctcttgtctt agaccgggtt gactttgtga agctcctgat tgaaaacgga gtgaacatgc
     1741 agcatttcct cactatcccg aggctggagg agctttacaa cactagactg ggcccaccaa
     1801 acacccttca tctgctggtg cgggatgtga agaagagcaa ccttccacct gactaccaca
     1861 tcagcctcat cgatatagga ctggtgttgg agtacctcat gggaggtgcc taccgctgca
     1921 actacactcg gaaaagcttc cggactctct acaacaactt gtttggccct aagaggccaa
     1981 aagcacttaa actcctggga atggaagatg atgagccccc agccaagggg aagaagaaaa
     2041 agaagaagaa gaaagaggag gagattgata tagatgtgga cgaccccgct gtgagtcggt
     2101 tccagtatcc gttccacgag ctcatggtat gggccgtgct catgaagcgc cagaagatgg
     2161 cagtcttcct gtggcagcgt ggggaggagt gcatggcaaa ggccttggtg gcctgtaagc
     2221 tctacaaggc catggcccac gagtcctcgg agagcgagct ggtggatgac atctcccagg
     2281 atctggacaa caattccaag gattttggcc agctcgctgt ggagctgtta gaccagtctt
     2341 acaagcacga tgagcaagtg gccatgaaac ttctgaccta tgagctcaag aactggagca
     2401 actcgacctg ccttaagctg gccgtggcgg ccaagcacag ggactttatc gctcacacct
     2461 gcagccagat gctgctgaca gacatgtgga tgggaaggct tcgcatgagg aagaaccctg
     2521 gcctgaaggt catcatgggg atccttatcc cgcccaccat cttgtttttg gaattccgtt
     2581 catatgatga cttctcctat caaacatcca aggagaatga agatggcaaa gaaaaggaag
     2641 aagagaatgt ggatgcaaat gcagatgctg gctcaagaaa gggggatgag gagaatgagc
     2701 acaaaaaaca gaggagcatt cccattggaa caaagatctg tgaattctat aatgcgccca
     2761 ttgtcaagtt ctggttttac acaatctcct acttgggcta cttgctgctg ttcaattatg
     2821 tcatcctggt gcggatggac ggctggcctt caccccaaga atggatcgtt atctcctaca
     2881 ttgtgagcct ggcactagag aaaatacgag agatcctcat gtcggaacca ggcaaactca
     2941 gccagaaaat caaagtgtgg ctccaagagt actggaacat cacagacctt gtggccattt
     3001 ccatgttcat ggttggggcc atccttcgcc tccagaacca gccatacatg ggctatggcc
     3061 gggtcatcta ctgtgtggat atcatcctct ggtacatccg agtgttagac atctttggtg
     3121 tcaacaagta tcttggcccc tatgtaatga tgattggaaa gatgatgatt gacatgctgt
     3181 actttgtggt cattatgctg gttgtgctga tgagtttcgg cgtagctcgg caagccatct
     3241 tgcacccaga ggagaagcct tcttggaaac tggcccgaaa catcttctac atgccctact
     3301 ggatgatcta cggagaagtg tttgcagacc agatagacct ctatgccatg gaaatcaacc
     3361 ctccttgtgg tgaaaatctc tatgatgagg aaggcaagag gctccctccc tgcatccctg
     3421 gtgcctggct cacacctgcc ctcatggcct gttatctcct ggtggccaat atcctgctgg
     3481 tcaacctgct gattgctgtt ttcaacaata ccttctttga agtcaagtca atatccaatc
     3541 aagtgtggaa gttccagcgg taccaactga tcatgacatt tcacgacagg ccggtcctgc
     3601 ccccgccaat gatcatctta agccacatct acatcatcgt tatgcgtctc agtggtcgct
     3661 gcagaaaaaa gagagaaggg gaccaggagg agcgggatcg tgggttgaag ctgttcctca
     3721 gcgacgagga actgaaaaaa ctgcatgagt ttgaggagca gtgcgtgcag gagcacttcc
     3781 gagaaaagga ggatgagcag cagtcgtcca gcgatgagcg catccgggtt acaagcgaga
     3841 gagttgaaaa tatgtcaatg aggctggagg aaatcaacga aagagaaaat ttcatgaagg
     3901 cgtctctgca gactgtcgac cttcggctct ctcagctgga ggagctatct ggcaggatgg
     3961 tgggcgctct ggagaatctg gcaggcatcg acaggtctga tctgatccag gctcgatcaa
     4021 gagcatcctc agaatgtgag gccacctacc tgctgcggca gagcagtatc aacagcgccg
     4081 atggctacag catgtaccgc taccatttca atggcgagga gcttctgttt gaggagcccg
     4141 ccctctccac ttcgccaggg acagtgttcc ggaaaaaaac ctgctccttc cgcgtgaagg
     4201 aagaggatgt aaaaccacac ctggaccagc caagtagcct gcaccacacc ccaggcccca
     4261 gcccgcctgc cacgccaggt cgcagccggc ttgcccttga tggtcccttg agcacagagt
     4321 tgagacctgg actggatcct ggtatctctg cgggtgagct tgatccgcgg gcagatttca
     4381 agagcgccga agttgcacca agtctgaaca cggcgaatgt tgcaagcact cagctgaccg
     4441 tcgaaagcac tgtttcccac ccactgcggg agagcaaact cgcgcgctac taccccggag
     4501 acctcaacac ctacaaaaca atgaagtcca gaagcttcgt ctattctgaa ggaagaaaac
     4561 ttgtccgagg tcttagcaac tggggtgccg agtacagttc aatcatggac caaacatgga
     4621 actcggcaga atggagatgt caagttcaaa ggatcacacg ctcccgcagc acagacatcc
     4681 cgtacattgt gtctgaagca gcctcccaag atgagtttga ggatgagcac agagaatctc
     4741 ttctggctcc tcagatctcc cgttcagccc tcacggtctc tgacaggccc gaaaaggaaa
     4801 acttgctgtc tgtgaagcca caccagactt taggattccc ctgcctacgg tcaagaagtt
     4861 tacatggtca tcctaggagt gccaaaccct ctcctagcaa attagacagg gcgggacatg
     4921 ccagcagcac cagcaactta gcagttatgt cagacgctcc agagggacaa aacacccagc
     4981 aggagaaagg aaacccggaa actgaatgct aa
//
LOCUS       NM_001106777             788 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ribosomal protein S12-like 4 (Rps12l4), mRNA.
ACCESSION   NM_001106777 XM_001080032 XM_235021
VERSION     NM_001106777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235021.1, XM_001080032.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..788
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /note="ribosomal protein S12-like 4"
                     /db_xref="GeneID:299713"
                     /db_xref="RGD:1561102"
     exon            1..788
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    312..314
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /note="upstream in-frame stop codon"
     CDS             390..788
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /codon_start=1
                     /product="uncharacterized protein LOC299713"
                     /protein_id="NP_001100247.1"
                     /db_xref="GeneID:299713"
                     /db_xref="RGD:1561102"
                     /translation="MAKEDTAAGVIMDVNTALQEVLKTALVHDGLARGIHEAAKALGK
                     RQAHLCVLAANCDKPMYIKLVETLCAEHQINLIKVDDNKKLGEWVGLCKIDRKGKPRK
                     VIGCSCVVVKDYGQESQAKDVIEEYFKCKK"
     misc_feature    435..722
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /note="Ribosomal protein L7Ae/L30e/S12e/Gadd45 family;
                     Region: Ribosomal_L7Ae; pfam01248"
                     /db_xref="CDD:426153"
     misc_feature    435..722
                     /gene="Rps12l4"
                     /gene_synonym="RGD1561102"
                     /note="Ribosomal protein L7Ae/L30e/S12e/Gadd45 family;
                     Region: Ribosomal_L7Ae; pfam01248"
                     /db_xref="CDD:426153"
ORIGIN      
        1 gctggcgcag ggtgcagcgt cctggtggtt gcagatcccg gtgcagtctg cggaggcggt
       61 ccactttcct ctaaatgcat tttcgcagga ggagccaggg ttacgtaata ataacgagaa
      121 agctcacccg cactcactgc gtgccaccaa cacagggcac cctcgtaccc gaggtgctta
      181 attttttgtt ctctgggtgg ccacctgccc acctttccgc ctccgcagga ctggaaactt
      241 gctacctctt gcgacttggg ttggaagtta cgtagtttta ggtagtgaaa gggtttggtg
      301 tttaaaattc ttagaaacgc ttcctcttcc tgcgcagccg ctcagaggct cgagtgcgct
      361 ccaggttgga tccacctgta acccacgcca tggccaagga agacactgct gctggagtta
      421 tcatggatgt taatactgct ttgcaagagg tgctgaagac cgccctggtc cacgatggcc
      481 tagccagagg aattcacgaa gctgccaaag ccttaggcaa gcgccaagcc catctctgtg
      541 tgcttgcagc caactgtgat aaacctatgt acatcaagtt ggtggaaacc ctttgtgctg
      601 agcaccaaat caacctaatt aaggttgatg acaacaagaa actaggagaa tgggtaggcc
      661 tctgcaaaat tgatcgaaag gggaaacctc gtaaagtgat aggttgcagc tgtgtggtgg
      721 ttaaagatta tggccaagaa tctcaagcta aagatgtcat cgaagagtac ttcaaatgca
      781 agaaatga
//
LOCUS       NM_001011928            1658 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus dipeptidase 2 (Dpep2), mRNA.
ACCESSION   NM_001011928 XM_214684
VERSION     NM_001011928.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1658)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088195.1.
            
            On Feb 11, 2005 this sequence version replaced XM_214684.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1658
                     /gene="Dpep2"
                     /note="dipeptidase 2"
                     /db_xref="GeneID:291984"
                     /db_xref="RGD:1305746"
     exon            1..48
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    11..13
                     /gene="Dpep2"
                     /note="upstream in-frame stop codon"
     exon            49..360
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1540
                     /gene="Dpep2"
                     /EC_number="3.4.13.19"
                     /codon_start=1
                     /product="dipeptidase 2 precursor"
                     /protein_id="NP_001011928.1"
                     /db_xref="GeneID:291984"
                     /db_xref="RGD:1305746"
                     /translation="MSLKGLEGHWVLSQVFLLVVVLLLLGPSEPLIRAQTKPGIADAS
                     TAPSPLRTLTKPAIFSIPTTPGNPNFPDLRDRTRALMQDFPLIDGHNDLPLVLRQFYQ
                     NGLQDTNLRNFTHGQTSLNRLKDGFVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRM
                     CASYSELELVTSVQALNSTQKLACLIGVEGGHSLDNSLAVLRSFYLLGVRYLTLTHTC
                     NTPWAESSSKDVHSFYSSVKGLTSFGEKVVAEMNRLGMMIDLSHVSDATARQALEVSQ
                     APVIFSHSAARAVCPNARNLPDDILQLLKKNGGIVMVTFAVGVLPCNPLANVSTVADH
                     FDHIRTVIGSEFIGVGGDYDGTKQFPQGLEDVSTYPVLIEELLRRGWGEQELQGVLRG
                     NLLRVFRQVEQVREKNKWQSPLEDMIPEEQLDSACHSVLPHRRQYPEKDPPETPDSHT
                     HKLSPKMPYSKSSPLRASSLTIMATFLGLLI"
     sig_peptide     95..184
                     /gene="Dpep2"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5M872.1)"
     mat_peptide     185..1480
                     /gene="Dpep2"
                     /product="Dipeptidase 2. /id=PRO_0000231607"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M872.1)"
     misc_feature    332..1294
                     /gene="Dpep2"
                     /note="Membrane dipeptidase (Peptidase family M19);
                     Region: Peptidase_M19; pfam01244"
                     /db_xref="CDD:395996"
     misc_feature    332..1294
                     /gene="Dpep2"
                     /note="Membrane dipeptidase (Peptidase family M19);
                     Region: Peptidase_M19; pfam01244"
                     /db_xref="CDD:395996"
     misc_feature    order(362..364,368..370,500..502,659..661,878..880,
                     941..943,974..976,1148..1150,1157..1159)
                     /gene="Dpep2"
                     /note="active site"
                     /db_xref="CDD:238626"
     misc_feature    order(362..364,368..370,500..502,659..661,878..880,
                     941..943,974..976,1148..1150,1157..1159)
                     /gene="Dpep2"
                     /note="active site"
                     /db_xref="CDD:238626"
     misc_feature    428..430
                     /gene="Dpep2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5M872.1); glycosylation site"
     misc_feature    order(506..508,533..541,545..550,557..559,569..571,
                     689..694,698..703,710..715)
                     /gene="Dpep2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238626"
     misc_feature    order(506..508,533..541,545..550,557..559,569..571,
                     689..694,698..703,710..715)
                     /gene="Dpep2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:238626"
     misc_feature    623..625
                     /gene="Dpep2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5M872.1); glycosylation site"
     misc_feature    1394..1486
                     /gene="Dpep2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M872.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            361..487
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..617
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..759
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..829
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1006
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1091
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1167
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1303
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1635
                     /gene="Dpep2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctggtc tgaggaactc atacatctga cccagcttcc acagtaaggt tttcgcgacc
       61 ctcatccgtg ccggtttgct ctgcactgag caagatgtca ctcaagggcc tcgagggtca
      121 ttgggtgctt agccaagtgt tcctgttggt ggtggtgctg ctgctgttag ggccctcaga
      181 acctctaata agggcccaga caaaaccagg catcgctgat gcttccactg caccaagccc
      241 cctcagaaca ctcaccaagc ctgccatctt cagcattcca accactcctg gcaaccccaa
      301 tttcccagac ctgcgagatc gcaccagagc cctgatgcag gacttcccgc ttatagatgg
      361 ccacaatgac ctgcctcttg ttctgaggca attttaccag aatggactac aagatactaa
      421 cctgagaaac ttcacccatg gccagaccag cctgaatagg cttaaagatg gctttgtggg
      481 agcccagttc tggtctgctt acgtgccgtg ccagacccag gaccgggatg ccctgcgtct
      541 cacactggag cagatcgacc tcattcgccg tatgtgtgcc tcttattctg agctggaact
      601 tgtgacctca gttcaagctc tgaacagcac ccagaaattg gcctgcctca ttggtgtgga
      661 gggtggccat tcactagaca atagcctcgc tgtgcttcga agtttctacc tgctgggggt
      721 gcgttacctg acactcacac acacctgcaa cacaccctgg gcagagagct catctaagga
      781 cgtccactca ttctacagca gtgtcaaagg actgaccagc tttggtgaga aggtggtggc
      841 agaaatgaat cgcttaggga tgatgattga tttgtcccat gtctcagacg ctacagcccg
      901 gcaggctttg gaagtatcac aagcacctgt gatcttttcc cactcggctg ccagagccgt
      961 gtgcccaaat gctcggaatc tccctgatga tatcctgcag ctcctgaaga agaatggtgg
     1021 catcgtgatg gtgacctttg ctgtaggagt gttaccctgc aacccattag ccaatgtatc
     1081 cactgtggca gatcactttg atcacatcag gacagtcatt ggatccgagt tcatcggagt
     1141 tggtggagat tatgacggta ccaagcagtt ccctcagggg ctggaggatg tgtctacata
     1201 cccagtgctc atagaggagt tgctgagacg aggctggggt gaacaagagc ttcaaggtgt
     1261 ccttcgaggg aacctgcttc gggtcttcag acaggtggaa caggtacgag agaaaaacaa
     1321 atggcagagt cccctggaag acatgattcc agaggagcag ctggacagtg cttgtcactc
     1381 agtcttacct catcggagac agtatccaga aaaggaccca ccagagactc cagactctca
     1441 tacacacaag ttatcaccca agatgccgta ctcaaaatcc tctcccctca gagcctcaag
     1501 ccttaccatt atggccacct ttttaggcct tctcatatga cttttagagg acacccagtc
     1561 ctctcagata tcattccggc accccaagag cccctccact ttatttcctg caagtaaatg
     1621 ctttgggtgt agaaaaaaaa aaaaaaaaaa aaaaaaaa
//
LOCUS       NM_199489               1215 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 7 (Ccr7), mRNA.
ACCESSION   NM_199489 XM_213486
VERSION     NM_199489.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Wurm,S., Steege,A., Rom-Jurek,E.M., van Roeyen,C.R., Kurtz,A.,
            Banas,B. and Banas,M.C.
  TITLE     CCR7 Is Important for Mesangial Cell Physiology and Repair
  JOURNAL   J Histochem Cytochem 66 (1), 7-22 (2018)
   PUBMED   29077526
  REMARK    GeneRIF: This study shows induction of renal CCR7 expression in the
            Model of Anti-Thy1.1 Mesangioproliferative Glomerulonephritis in
            rat.
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Ma,T., Luan,S.L., Huang,H., Sun,X.K., Yang,Y.M., Zhang,H.,
            Han,W.D., Li,H. and Han,Y.
  TITLE     Upregulation of CC Chemokine Receptor 7 (CCR7) Enables Migration of
            Xenogeneic Human Adipose-Derived Mesenchymal Stem Cells to Rat
            Secondary Lymphoid Organs
  JOURNAL   Med Sci Monit 22, 5206-5217 (2016)
   PUBMED   28035134
  REMARK    GeneRIF: These results suggest that upregulation of rat CCR7
            expression does not change the phenotype, differentiation, or
            proliferation capacity of human adipose-derived stem cells (hASCs),
            but does enable efficient migration of hASCs to rat secondary
            lymphoid organs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Zhang,W., Tu,G., Lv,C., Long,J., Cong,L. and Han,Y.
  TITLE     Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7
            interaction via PI3K/Akt pathway and is involved in CCL19-driven
            BMSCs migration
  JOURNAL   Biochem Biophys Res Commun 451 (2), 222-228 (2014)
   PUBMED   25086360
  REMARK    GeneRIF: CCL19/CCR7 contributes to the migration of bone marrow
            mesenchymal stem cells by upregulating MMP9 potentially via the
            PI3K/Akt pathway.
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Nakamura,K., White,A.J., Parnell,S.M., Lane,P.J., Jenkinson,E.J.,
            Jenkinson,W.E. and Anderson,G.
  TITLE     Differential requirement for CCR4 in the maintenance but not
            establishment of the invariant Vgamma5(+) dendritic epidermal
            T-cell pool
  JOURNAL   PLoS One 8 (9), e74019 (2013)
   PUBMED   24069263
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Chiang,Y.J., Ho,K.C., Sun,C.T., Chiu,J.J., Lee,F.J., Liao,F.,
            Yang-Yen,H.F. and Yen,J.J.
  TITLE     CBAP functions as a novel component in chemokine-induced
            ZAP70-mediated T-cell adhesion and migration
  JOURNAL   PLoS One 8 (4), e61761 (2013)
   PUBMED   23620790
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Debes,G.F., Bonhagen,K., Wolff,T., Kretschmer,U., Krautwald,S.,
            Kamradt,T. and Hamann,A.
  TITLE     CC chemokine receptor 7 expression by effector/memory CD4+ T cells
            depends on antigen specificity and tissue localization during
            influenza A virus infection
  JOURNAL   J Virol 78 (14), 7528-7535 (2004)
   PUBMED   15220427
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Gibejova,A., Mrazek,F., Subrtova,D., Sekerova,V., Szotkowska,J.,
            Kolek,V., du Bois,R.M. and Petrek,M.
  TITLE     Expression of macrophage inflammatory protein-3 beta/CCL19 in
            pulmonary sarcoidosis
  JOURNAL   Am J Respir Crit Care Med 167 (12), 1695-1703 (2003)
   PUBMED   12626344
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Bouchon,A., Hernandez-Munain,C., Cella,M. and Colonna,M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Forster,R., Schubel,A., Breitfeld,D., Kremmer,E., Renner-Muller,I.,
            Wolf,E. and Lipp,M.
  TITLE     CCR7 coordinates the primary immune response by establishing
            functional microenvironments in secondary lymphoid organs
  JOURNAL   Cell 99 (1), 23-33 (1999)
   PUBMED   10520991
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Yoshida,R., Nagira,M., Kitaura,M., Imagawa,N., Imai,T. and
            Yoshie,O.
  TITLE     Secondary lymphoid-tissue chemokine is a functional ligand for the
            CC chemokine receptor CCR7
  JOURNAL   J Biol Chem 273 (12), 7118-7122 (1998)
   PUBMED   9507024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY379972.1.
            
            On Aug 30, 2012 this sequence version replaced NM_199489.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY379972.1, BC089762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1215              AY379972.1         4-1218
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1215
                     /gene="Ccr7"
                     /note="C-C motif chemokine receptor 7"
                     /db_xref="GeneID:287673"
                     /db_xref="RGD:735151"
     exon            1..88
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    10..12
                     /gene="Ccr7"
                     /note="upstream in-frame stop codon"
     CDS             79..1215
                     /gene="Ccr7"
                     /note="C-C chemokine receptor type 7; chemokine (C-C
                     motif) receptor 7"
                     /codon_start=1
                     /product="C-C chemokine receptor type 7 precursor"
                     /protein_id="NP_955783.1"
                     /db_xref="GeneID:287673"
                     /db_xref="RGD:735151"
                     /translation="MDLGKPTKNVLVVALLVIFQVCFCQDEVTDDYIGENTTVDYTLY
                     ESVCFKKDVRNFKAWFLPLMYSVICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAV
                     ADILFLMILPFWAYSEAKSWIFGAYLCKSIFGIYKLSFFSGMLLLLCISIDRYVAIVQ
                     AVSAHRHRARVLLISKLSCIGIWTLAFFLSIPELLYSGLQKNSGEDTWRCSLVSAQVE
                     ALIAIQVAQMVVGFVLPMLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFVVFQ
                     LPYNGVVLAQTVANFNITNSSCEASKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFR
                     SDLFKLFKDLGCLSQERLRQWSSCRHVRHTSVSMEAETTTTFSP"
     sig_peptide     79..150
                     /gene="Ccr7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    253..1089
                     /gene="Ccr7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    253..1089
                     /gene="Ccr7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    259..333
                     /gene="Ccr7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    259..333
                     /gene="Ccr7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    358..423
                     /gene="Ccr7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    358..423
                     /gene="Ccr7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    466..534
                     /gene="Ccr7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    466..534
                     /gene="Ccr7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    607..657
                     /gene="Ccr7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    607..657
                     /gene="Ccr7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    739..810
                     /gene="Ccr7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    739..810
                     /gene="Ccr7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    862..930
                     /gene="Ccr7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    862..930
                     /gene="Ccr7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    991..1068
                     /gene="Ccr7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    991..1068
                     /gene="Ccr7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            89..138
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
     exon            139..1215
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaggggt aactggagac agagacaaga gacacaagcc gagccttcct gtgtgacttc
       61 aactgcccag agagcatcat ggacctgggg aagcccacga aaaacgtgct ggtggtggct
      121 ctcctggtca ttttccaggt gtgcttctgc caagatgagg tcacagacga ctacatcggc
      181 gagaacacca ccgtggacta caccctgtat gagtcggtgt gcttcaagaa ggatgtgcgg
      241 aactttaagg cctggttcct ccctctcatg tactcagtca tttgcttcgt gggcctgcta
      301 ggcaatgggc tggtggtgct gacatacatc tatttcaaga gactgaagac catgacggat
      361 acctacctgc tcaacctggc cgtggcagac atcctcttcc tcatgatcct tcccttctgg
      421 gcctacagcg aagccaagtc ctggatcttt ggtgcctacc tgtgtaagag catctttggc
      481 atctacaagt taagcttctt cagcgggatg ttgctgctcc tgtgtatcag cattgaccgc
      541 tatgtggcca tcgtccaggc cgtgtcagcc caccggcacc gcgcccgcgt gcttctcatc
      601 agcaagctgt cctgtatagg catctggacg ctggcctttt tcctttctat ccctgagctg
      661 ctctacagcg gcctccagaa gaacagcggc gaggacacgt ggagatgctc cctggtcagt
      721 gcccaagtgg aggccttgat cgccatccaa gtggcccaga tggttgttgg gtttgtactg
      781 cctatgctgg ctatgagttt ctgctacctg gttatcatcc gcactctgct ccaggcgcga
      841 aacttcgagc ggaacaaggc catcaaggtg atcatcgctg tggtcgtagt gttcgtcgtc
      901 ttccagctgc cctacaatgg ggtggtcctg gcccagaccg tggccaattt caacatcacc
      961 aatagcagct gcgaagccag caagcagctc aacattgcct atgacgtcac ctacagcctg
     1021 gcctccgtcc gctgctgtgt caaccctttc ttgtatgcct tcatcggcgt caagttccgc
     1081 agcgacctct tcaagctctt caaggacttg ggctgcctca gccaggaacg gctccggcag
     1141 tggtcttcct gccgccatgt acggcacacg tccgtgagca tggaggcgga gactaccacc
     1201 accttctccc cgtag
//
LOCUS       NM_001166682             957 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 117 (Tas2r117),
            mRNA.
ACCESSION   NM_001166682
VERSION     NM_001166682.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY486339.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..957
                     /gene="Tas2r117"
                     /note="taste receptor, type 2, member 117"
                     /db_xref="GeneID:100310880"
                     /db_xref="RGD:2314258"
     CDS             1..957
                     /gene="Tas2r117"
                     /note="T2R39; T2R117; taste receptor type 2 member 39"
                     /codon_start=1
                     /product="taste receptor type 2 member 117"
                     /protein_id="NP_001160154.1"
                     /db_xref="GeneID:100310880"
                     /db_xref="RGD:2314258"
                     /translation="MQHNLKTIFVISHSTLTIILFTELVTGIIGNGFMALVHCMDWLR
                     RKKISLVNQILTALAISRIFQLCLLFISLVISFSYPDLTTTSLIKVTCNLWIIVNHFN
                     IWLATCLGIFYFLKISNFSNSLFLYLKWRVEKVVLVTLLVSLVLLTLNSLLINLEINI
                     CINEYQRNITYSFNSYYHANCHRQMLSLHIIFLSVPFVLSLSTFLLLIFSLGTHHKKM
                     QQHVQGRRDASTMAHFKALQTVIAFLLLYSIFILSVLVQIWKYELLKKNLFILFCQVA
                     YVAFPSFHSYILILGDMKMRQACLSVLWWQKFRKNYVEPLDL"
     misc_feature    43..909
                     /gene="Tas2r117"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    43..909
                     /gene="Tas2r117"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    43..120
                     /gene="Tas2r117"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    43..120
                     /gene="Tas2r117"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    49..111
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    154..228
                     /gene="Tas2r117"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    154..228
                     /gene="Tas2r117"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    160..222
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    265..333
                     /gene="Tas2r117"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    265..333
                     /gene="Tas2r117"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    280..342
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    403..465
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    412..462
                     /gene="Tas2r117"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    412..462
                     /gene="Tas2r117"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    502..504
                     /gene="Tas2r117"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q675B8.1); glycosylation site"
     misc_feature    544..615
                     /gene="Tas2r117"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    544..615
                     /gene="Tas2r117"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    568..630
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    688..765
                     /gene="Tas2r117"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    688..765
                     /gene="Tas2r117"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    715..777
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     misc_feature    799..876
                     /gene="Tas2r117"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    799..876
                     /gene="Tas2r117"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    805..867
                     /gene="Tas2r117"
                     /note="propagated from UniProtKB/Swiss-Prot (Q675B8.1);
                     transmembrane region"
     exon            1..957
                     /gene="Tas2r117"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaacata atttgaagac aatatttgtt atctctcaca gcacacttac aatcatttta
       61 ttcactgaat tagtaactgg aattatagga aatgggttca tggccctggt gcactgtatg
      121 gactggctaa ggagaaagaa aatatcatta gttaatcaaa tcctcactgc tttggcaatt
      181 tccagaattt ttcaactctg tttattgttt ataagtttag tcatctcctt ttcatatcca
      241 gatttaacta caacttcact gataaaagtc acttgtaatc tttggattat agtcaaccat
      301 ttcaacatct ggcttgctac atgcctcggt atcttttatt ttctcaagat atccaatttt
      361 tctaactctc tttttcttta tctaaagtgg agagttgaaa aagtagtttt agttacactg
      421 ctggtgtcac tggtcctact gactttaaat agtttactaa ttaacttgga aattaacata
      481 tgcataaatg aataccaaag aaacataaca tacagcttca attcttatta tcatgcaaat
      541 tgtcacaggc agatgttaag ccttcatatt attttcctgt ctgtcccctt tgttttgtcc
      601 ctgtcaactt ttctcctgct catcttctct ctggggacac atcacaagaa gatgcagcag
      661 catgttcaag gacgccgaga tgccagtact atggcccact tcaaagcctt gcaaaccgtg
      721 attgcctttc tcctactata ctctattttt attctgtctg tcttagtaca aatttggaaa
      781 tatgaattac tgaagaaaaa tcttttcatt ttattttgtc aggttgcata tgtagctttt
      841 ccttcattcc attcatatat tctgattcta ggagacatga agatgagaca ggcctgtctc
      901 tctgtattgt ggtggcagaa attcaggaaa aattatgtag aacctttaga tctctaa
//
LOCUS       NM_017274               2646 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus glycerol-3-phosphate acyltransferase,
            mitochondrial (Gpam), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017274
VERSION     NM_017274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Cattaneo,E.R., Pellon-Maison,M., Rabassa,M.E., Lacunza,E.,
            Coleman,R.A. and Gonzalez-Baro,M.R.
  TITLE     Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic
            germ cells and incorporates arachidonic acid into triacylglycerols
  JOURNAL   PLoS One 7 (8), e42986 (2012)
   PUBMED   22905194
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Guha,P., Aneja,K.K., Shilpi,R.Y. and Haldar,D.
  TITLE     Transcriptional regulation of mitochondrial glycerophosphate
            acyltransferase is mediated by distal promoter via ChREBP and
            SREBP-1
  JOURNAL   Arch Biochem Biophys 490 (2), 85-95 (2009)
   PUBMED   19682972
  REMARK    GeneRIF: ChREBP and SREBP-1 bind to the mtGPAT distal promoter.
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Karlsson,E.A., Wang,S., Shi,Q., Coleman,R.A. and Beck,M.A.
  TITLE     Glycerol-3-phosphate acyltransferase 1 is essential for the immune
            response to infection with coxsackievirus B3 in mice
  JOURNAL   J Nutr 139 (4), 779-783 (2009)
   PUBMED   19193813
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Rodriguez-Calvo,R., Barroso,E., Serrano,L., Coll,T., Sanchez,R.M.,
            Merlos,M., Palomer,X., Laguna,J.C. and Vazquez-Carrera,M.
  TITLE     Atorvastatin prevents carbohydrate response element binding protein
            activation in the fructose-fed rat by activating protein kinase A
  JOURNAL   Hepatology 49 (1), 106-115 (2009)
   PUBMED   19053045
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Onorato,T.M. and Haldar,D.
  TITLE     Casein kinase II stimulates rat liver mitochondrial
            glycerophosphate acyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1091-1096 (2002)
   PUBMED   12207885
  REMARK    GeneRIF: Casein kinase II stimulates rat liver mitochondrial
            glycerophosphate acyltransferase activity
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Park,H., Kaushik,V.K., Constant,S., Prentki,M., Przybytkowski,E.,
            Ruderman,N.B. and Saha,A.K.
  TITLE     Coordinate regulation of malonyl-CoA decarboxylase,
            sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase
            by AMP-activated protein kinase in rat tissues in response to
            exercise
  JOURNAL   J Biol Chem 277 (36), 32571-32577 (2002)
   PUBMED   12065578
  REMARK    GeneRIF: Gpam regulation in rats in response to exercise
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Balija,V.S., Chakraborty,T.R., Nikonov,A.V., Morimoto,T. and
            Haldar,D.
  TITLE     Identification of two transmembrane regions and a cytosolic domain
            of rat mitochondrial glycerophosphate acyltransferase
  JOURNAL   J Biol Chem 275 (41), 31668-31673 (2000)
   PUBMED   10924502
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Ganesh Bhat,B., Wang,P., Kim,J.H., Black,T.M., Lewin,T.M.,
            Fiedorek,F.T. Jr. and Coleman,R.A.
  TITLE     Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and
            characterization of the cDNA and expressed protein
  JOURNAL   Biochim Biophys Acta 1439 (3), 415-423 (1999)
   PUBMED   10446428
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Lee,Y., Hirose,H., Zhou,Y.T., Esser,V., McGarry,J.D. and Unger,R.H.
  TITLE     Increased lipogenic capacity of the islets of obese rats: a role in
            the pathogenesis of NIDDM
  JOURNAL   Diabetes 46 (3), 408-413 (1997)
   PUBMED   9032096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF021348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021348.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2646
                     /gene="Gpam"
                     /note="glycerol-3-phosphate acyltransferase,
                     mitochondrial"
                     /db_xref="GeneID:29653"
                     /db_xref="RGD:61847"
     exon            1..126
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            127..261
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    154..156
                     /gene="Gpam"
                     /note="upstream in-frame stop codon"
     CDS             160..2646
                     /gene="Gpam"
                     /EC_number="2.3.1.15"
                     /note="GPAT; GPAT-1"
                     /codon_start=1
                     /product="glycerol-3-phosphate acyltransferase 1,
                     mitochondrial"
                     /protein_id="NP_058970.1"
                     /db_xref="GeneID:29653"
                     /db_xref="RGD:61847"
                     /translation="MEESSVTIGTIDVSYLPNSSEYSLGRCKHTNEDWVDCGFKPTFF
                     RSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHR
                     GWLARRLSYILFVQERDVHKGMFATSITDNVLNSSRVQEAIAEVAAELNPDGSAQQQS
                     KAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAAT
                     ETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFI
                     RRRLDETPDGRKDILYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSV
                     VVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKN
                     YGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALLPAILPSRPDAAAAEHEDMSSN
                     ESRNAADEAFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVED
                     FFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSV
                     FELNFYSNGVLHVFIMEAIIACSIYAVQNKRGSGGSAGGLGNLISQEQLVRKAASLCY
                     LLSNEGTISLPCQTFYQVCQETVGKFIQYGILTVAEQDDQEDVSPGLAEQQWNKKLPE
                     PLNWRSDEEDEDSDFGEEQRDCYLKVSQAKEHQQFITFLQRLLGPLLEAYSSAAIFVH
                     TFRGPVPESEYLQKLHRYLLTRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQK
                     RASVLELSTTFLPQGSRQKLLEYILSFVVL"
     misc_feature    397..519
                     /gene="Gpam"
                     /note="propagated from UniProtKB/Swiss-Prot (P97564.3);
                     Region: Important for mitochondrial localization.
                     /evidence=ECO:0000250|UniProtKB:Q9HCL2"
     misc_feature    550..2127
                     /gene="Gpam"
                     /note="Glycerol-3-phosphate O-acyltransferase [Lipid
                     transport and metabolism]; Region: PlsB; COG2937"
                     /db_xref="CDD:442180"
     misc_feature    550..2127
                     /gene="Gpam"
                     /note="Glycerol-3-phosphate O-acyltransferase [Lipid
                     transport and metabolism]; Region: PlsB; COG2937"
                     /db_xref="CDD:442180"
     misc_feature    760..1392
                     /gene="Gpam"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: GPAT-like; Region:
                     LPLAT_DHAPAT-like; cd07993"
                     /db_xref="CDD:153255"
     misc_feature    760..1392
                     /gene="Gpam"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: GPAT-like; Region:
                     LPLAT_DHAPAT-like; cd07993"
                     /db_xref="CDD:153255"
     misc_feature    order(847..849,856..858,862..864,925..936,1105..1113)
                     /gene="Gpam"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153255"
     misc_feature    order(847..849,856..858,862..864,925..936,1105..1113)
                     /gene="Gpam"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153255"
     misc_feature    847..864
                     /gene="Gpam"
                     /note="propagated from UniProtKB/Swiss-Prot (P97564.3);
                     Region: HXXXXD motif.
                     /evidence=ECO:0000250|UniProtKB:Q9HCL2"
     misc_feature    1297..1299
                     /gene="Gpam"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P97564.3); phosphorylation site"
     misc_feature    2221..2223
                     /gene="Gpam"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P97564.3); phosphorylation site"
     misc_feature    2242..2244
                     /gene="Gpam"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P97564.3); phosphorylation site"
     misc_feature    2497..2499
                     /gene="Gpam"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q61586; propagated from
                     UniProtKB/Swiss-Prot (P97564.3); acetylation site"
     misc_feature    2509..2511
                     /gene="Gpam"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q61586; propagated from
                     UniProtKB/Swiss-Prot (P97564.3); acetylation site"
     exon            262..384
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            385..458
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            459..572
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            573..719
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            720..816
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            817..953
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1053
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1266
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1380
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1466
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1582
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1653
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1918
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2061
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2139
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2280
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2470
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2529
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2646
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgaataag cctctggagg agctgctgaa tcacccccgc cccaggctgt cttctgaagc
       61 tgtctgggga tagctttgct aatcaactga ctggaaataa ttccagacac cacatcaagg
      121 atacagctca tgttttgttt gggacttcca cgttgagtca tggaggagtc ttcagtgaca
      181 attggcacaa tagacgtttc ttatctgccc aattcatcag aatacagcct tggccgatgt
      241 aaacacacga atgaggactg ggttgactgt ggcttcaaac ctaccttctt cagatccgca
      301 acgctgaaat ggaaggagag cctcatgagc cggaagaggc ccttcgtggg aaggtgttgc
      361 tattcatgca cgcctcagag ctgggaaagg tttttcaacc ccagtatccc atctctgggt
      421 ttgcggaatg ttatttatat caatgaaact cacacaaggc accgaggatg gctggcaaga
      481 cggctttctt acatcctttt tgttcaagag cgcgatgtcc acaagggcat gtttgccacc
      541 agtatcactg acaatgtact gaatagcagc agagtccaag aggcaattgc tgaagtggct
      601 gcagaattga acccggatgg atctgcccag cagcagtcca aagccatcca gaaagtgaaa
      661 aggaaagcca ggaagatcct ccaggaaatg gttgctacag tctcccccgg gatgatcagg
      721 ctgactggct gggtgttact aaagctcttc aacagcttct tctggaacat tcagattcac
      781 aagggtcaac ttgagatggt gaaagctgca actgagacga atctgccgct cttgtttctg
      841 ccggtgcaca gatcccacat cgactacctg ctgctcacct tcatcctctt ctgccacaac
      901 atcaaagctc catacatcgc ctcgggcaac aacctcaaca tccccatctt cagtaccttg
      961 attcacaagc ttgggggctt tttcataaga cggaggcttg acgaaactcc agatggacgc
     1021 aaagacattc tgtacagagc gttgctccat gggcatatag ttgaactcct ccgacagcag
     1081 cagttcctgg agatcttcct ggaaggcacc cgctcccgca gtggcaagac ctcctgtgcc
     1141 cgggccgggc tcctgtcagt ggtagtggat actctgtcat ccaacaccat ccctgacatc
     1201 ctggtcatcc ctgtgggcat ctcgtatgat cggataatcg aaggtcacta caatggtgaa
     1261 cagttgggca agcccaagaa gaatgaaagt ctctggagtg tggcaagagg cgttatcaga
     1321 atgctgcgga aaaactacgg ctatgtccga gtggactttg cacagccatt ttctttgaag
     1381 gaatatttag aaggccaaag tcagaaacct gtatctgctc ccctctcttt ggagcaagca
     1441 ctgttaccag caatccttcc ttcaagacct gatgctgctg ctgccgaaca tgaagacatg
     1501 tccagtaatg agtcgagaaa cgcggcagac gaagccttcc gaaggaggct gatcgcaaac
     1561 ctggcggagc acattctctt caccgccagc aagtcctgcg ctatcatgtc cacccacatt
     1621 gtggcctgcc tgctcctcta cagacacagg cagggaatcc acctctccac gctggtggaa
     1681 gacttctttg tgatgaagga ggaagtccta gctcgggatt ttgacctggg cttctccggg
     1741 aattcagaag atgtagtcat gcatgctatt cagcttctgg ggaactgtgt cacaatcacc
     1801 cacactagca ggaaggatga attctttatt actcccagca caactgtccc gtccgtcttt
     1861 gaactcaact tctacagcaa tggggtactt catgtcttta tcatggaagc catcatagct
     1921 tgcagcattt atgcagtcca gaataagagg ggttccggag ggtctgccgg aggccttggc
     1981 aacctgatca gccaggagca gctggtgcgg aaggccgcca gcctgtgcta ccttctctct
     2041 aatgaaggta ccatttctct gccctgccag acattttacc aggtttgtca agagacagta
     2101 ggaaagttca tccagtacgg aattctcaca gtggcagagc aagatgacca ggaagatgtc
     2161 agtcctggcc ttgcagagca gcagtggaac aagaagcttc cggagcctct gaactggaga
     2221 agtgacgaag aagatgagga cagtgacttt ggtgaggagc agcgtgattg ctacctgaag
     2281 gtgagccagg ccaaggagca ccagcaattc atcacctttc tgcagaggct tctggggccc
     2341 ctgctagaag cctacagctc tgctgccatc tttgtccaca ccttccgcgg cccagtcccg
     2401 gagtctgagt acctgcagaa gctgcacagg taccttctca ccaggacgga gaggaacgtc
     2461 gcggtgtacg ctgagagtgc cacatactgt cttgtgaaga atgctgtgaa aatgtttaag
     2521 gacatcgggg ttttcaaaga gaccaagcag aagcgagcgt ctgtcttaga actgagcacc
     2581 actttcctac ctcagggcag ccggcagaag ctcctggaat acattctgag cttcgtggtg
     2641 ctgtag
//
LOCUS       NM_022942               1878 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus butyrylcholinesterase (Bche), mRNA.
ACCESSION   NM_022942
VERSION     NM_022942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Szmicsekova,K., Bies Pivackova,L., Kilianova,Z., Slobodova,L.,
            Krenek,P. and Hrabovska,A.
  TITLE     Aortic butyrylcholinesterase is reduced in spontaneously
            hypertensive rats
  JOURNAL   Physiol Res 70 (5), 809-813 (2021)
   PUBMED   34505519
  REMARK    GeneRIF: Aortic butyrylcholinesterase is reduced in spontaneously
            hypertensive rats.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Munir,S., Habib,R., Awan,S., Bibi,N., Tanveer,A., Batool,S. and
            Nurulain,S.M.
  TITLE     Biochemical Analysis and Association of Butyrylcholinesterase SNPs
            rs3495 and rs1803274 with Substance Abuse Disorder
  JOURNAL   J Mol Neurosci 67 (3), 445-455 (2019)
   PUBMED   30707402
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Tonin,A.A., da Silva,A.S., Thorstenberg,M.L., Castilhos,L.G.,
            Franca,R.T., Leal,D.B., Duarte,M.M., Vogel,F.S., de La Rue,M.L. and
            dos Anjos Lopes,S.T.
  TITLE     Influence of Toxoplasma gondii acute infection on cholinesterase
            activities of Wistar rats
  JOURNAL   Korean J Parasitol 51 (4), 421-426 (2013)
   PUBMED   24039284
  REMARK    GeneRIF: No significant difference was observed in the activity of
            BChE in serum after Toxoplasma gondii infection.
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Koohestani,F., Brown,C.M. and Meisami,E.
  TITLE     Differential effects of developmental hypo- and hyperthyroidism on
            acetylcholinesterase and butyrylcholinesterase activity in the
            spinal cord of developing postnatal rat pups
  JOURNAL   Int J Dev Neurosci 30 (7), 570-577 (2012)
   PUBMED   22982053
  REMARK    GeneRIF: the neurochemical development of glia and other
            non-neuronal cells, where BuChE is mainly localized, is
            comparatively unaffected cy hypo- and hyperthyroidism
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Koohestani,F., Brown,C.M. and Meisami,E.
  TITLE     Postnatal growth hormone deficiency in growing rats causes marked
            decline in the activity of spinal cord acetylcholinesterase but not
            butyrylcholinesterase
  JOURNAL   Int J Dev Neurosci 30 (7), 578-583 (2012)
   PUBMED   22922167
  REMARK    GeneRIF: the absence of any effects on BuChE activity implies that
            growth hormone does not affect the development of non-neuronal
            elements
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Basu,P.S., Batabyal,S.K., Bhattacharya,A. and Datta,T.K.
  TITLE     Cholinesterase activities in cerebrospinal fluid of patients with
            idiopathic convulsive disorders
  JOURNAL   Clin Chim Acta 235 (1), 107-112 (1995)
   PUBMED   7634486
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   McGuire,M.C., Nogueira,C.P., Bartels,C.F., Lightstone,H., Hajra,A.,
            Van der Spek,A.F., Lockridge,O. and La Du,B.N.
  TITLE     Identification of the structural mutation responsible for the
            dibucaine-resistant (atypical) variant form of human serum
            cholinesterase
  JOURNAL   Proc Natl Acad Sci U S A 86 (3), 953-957 (1989)
   PUBMED   2915989
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Ruberg,M., Villageois,A., Bonnet,A.M., Pillon,B., Rieger,F. and
            Agid,Y.
  TITLE     Acetylcholinesterase and butyrylcholinesterase activity in the
            cerebrospinal fluid of patients with neurodegenerative diseases
            involving cholinergic systems
  JOURNAL   J Neurol Neurosurg Psychiatry 50 (5), 538-543 (1987)
   PUBMED   2953866
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Godfrey,D.A. and Matschinsky,F.M.
  TITLE     Enzymes of the cholinergic system in islets of Langerhans
  JOURNAL   J Histochem Cytochem 23 (9), 645-651 (1975)
   PUBMED   126256
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Flumerfelt,B.A. and Lewis,P.R.
  TITLE     Cholinesterase activity in the hypoglossal nucleus of the rat and
            the changes produced by axotomy: a light and electron microscopic
            study
  JOURNAL   J Anat 119 (Pt 2), 309-331 (1975)
   PUBMED   1133098
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF244349.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF244349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1878
                     /gene="Bche"
                     /note="butyrylcholinesterase"
                     /db_xref="GeneID:65036"
                     /db_xref="RGD:619996"
     exon            1..58
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1586
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1878
                     /gene="Bche"
                     /EC_number="3.1.1.8"
                     /note="cholinesterase"
                     /codon_start=1
                     /product="cholinesterase precursor"
                     /protein_id="NP_075231.1"
                     /db_xref="GeneID:65036"
                     /db_xref="RGD:619996"
                     /translation="MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPIL
                     GGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGS
                     EMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVE
                     RVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLF
                     GESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCS
                     KENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGK
                     VKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAI
                     LFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSK
                     LPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQG
                     NSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKVLEITGDIDEREQEW
                     KAGFHRWSNYMMDWKNQFNDYTSKKETCTDL"
     sig_peptide     85..153
                     /gene="Bche"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    157..1719
                     /gene="Bche"
                     /note="Carboxylesterase family; Region: COesterase;
                     pfam00135"
                     /db_xref="CDD:395084"
     misc_feature    157..1719
                     /gene="Bche"
                     /note="Carboxylesterase family; Region: COesterase;
                     pfam00135"
                     /db_xref="CDD:395084"
     misc_feature    order(496..504,742..750,757..759,1210..1212,1222..1227,
                     1330..1332,1468..1470,1477..1479)
                     /gene="Bche"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:238191"
     misc_feature    order(496..504,742..750,757..759,1210..1212,1222..1227,
                     1330..1332,1468..1470,1477..1479)
                     /gene="Bche"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:238191"
     misc_feature    order(745..747,1126..1128,1465..1467)
                     /gene="Bche"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     misc_feature    order(745..747,1126..1128,1465..1467)
                     /gene="Bche"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     misc_feature    1762..1866
                     /gene="Bche"
                     /note="Acetylcholinesterase tetramerization domain;
                     Region: AChE_tetra; pfam08674"
                     /db_xref="CDD:430146"
     misc_feature    1762..1866
                     /gene="Bche"
                     /note="Acetylcholinesterase tetramerization domain;
                     Region: AChE_tetra; pfam08674"
                     /db_xref="CDD:430146"
     exon            1587..1753
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1878
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcattac aagattgcca ctttgcaaac tccctcttcc ttttctgcag cgattcggaa
       61 atcaatctgc agactcagca taccatggtc acagaaattc acttcctcct atggattctt
      121 ctgctctgca tgctttttgg gaagtcacac actgaagaag acgtcataat tacaaccaag
      181 actggaagag tccgagggct gagcatgccc attctaggtg gcacagtgac tgcctttctc
      241 ggtatcccct atgcacagcc tcctctgggt agcctaagat tcaaaaagcc acaaccttta
      301 aacaaatggc ctgatgtcta taatgccact aaatatgcaa attcttgtta tcagaatata
      361 gatcaagcct tcccaggctt ccaggggtca gaaatgtgga atccaaacac gaacctcagt
      421 gaagactgct tgtatctgaa tgtttggatt ccagtaccta agcccaagaa tgcgactgtc
      481 atggtgtggg tctatggtgg tggctttcaa actgggacct cctctctacc cgtttatgat
      541 gggaaatttc tcactcgtgt tgaaagagtt attgtagttt caatgaacta tagggtaggt
      601 gccctaggat tcctagcttt tccaggaaat tctgaggctc caggaaacat gggtttattt
      661 gatcaacagt tggcacttca gtggatccaa agaaatatag ctgctttcgg agggaatcct
      721 aaaagtgtaa cactttttgg agaaagtgca ggagctgctt cagttagctt acatttgcta
      781 tgtccccaaa gttacccttt gtttactaga gccattctag aaagtggctc ctctaatgcc
      841 ccctgggcag taaagcatcc agaggaagcc agaaacagaa ccttaacctt agctaaattt
      901 attggttgct caaaggagaa tgagaaggag ataattacat gccttcgaag taaagatcct
      961 caggaaattc ttctgaatga aaagttagtt ctcccctctg attccatcag atcgattaat
     1021 tttggtccaa cagtggatgg cgattttctc actgatatgc cccacacact actccaactt
     1081 ggaaaagtga aaacagctca gatcttagtg ggcgttaaca aggatgaagg gacagctttc
     1141 ctagtgtacg gtgctcctgg tttcagcaaa gacaatgata gtcttatcac acggagggaa
     1201 tttcaagaag gtttaaatat gtatttccct ggagtgagca gcttgggaaa ggaagcaatc
     1261 cttttctact atgtggactg gttaggtgac cagacaccgg aagtctaccg tgaagctttc
     1321 gatgatatta ttggagatta caacatcata tgccctgcac tggagtttac caagaaattt
     1381 gcagaactag aaattaatgc ctttttctac tattttgaac accgatcttc caaactacct
     1441 tggccagaat ggatgggagt aatgcatggc tatgaaattg aatttgtatt tggcttaccc
     1501 ctggaaagaa gagttaatta cacaagggct gaggaaatct ttagtcgatc cataatgaaa
     1561 acttgggcaa attttgcaaa atatggacat cccaatggga ctcagggcaa tagcacagtg
     1621 tggcctgtct tcacaagtac tgaacaaaaa tacctaacct tgaacacaga gaagtcaaaa
     1681 ataaactcta aactccgggc tccccagtgc caattctgga gactattttt tccaaaagtc
     1741 ttggaaataa caggagatat tgatgaaagg gagcaagagt ggaaggcagg attccatcgc
     1801 tggagcaatt acatgatgga ctggaaaaat caatttaacg attacactag caagaaagag
     1861 acttgtacag atctctaa
//
LOCUS       NM_001107205            2002 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member
            3-like 3 (Abcg3l3), mRNA.
ACCESSION   NM_001107205 XM_001064705 XM_223174
VERSION     NM_001107205.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474022.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223174.4, XM_001064705.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2002
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /note="ATP-binding cassette, subfamily G (WHITE), member
                     3-like 3"
                     /db_xref="GeneID:305142"
                     /db_xref="RGD:1564709"
     exon            1..39
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            40..261
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2002
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /codon_start=1
                     /product="ATP-binding cassette, sub-family G (WHITE),
                     member 3 family member"
                     /protein_id="NP_001100675.1"
                     /db_xref="GeneID:305142"
                     /db_xref="RGD:1564709"
                     /translation="MSSSNDPTVIPMAERRYGDLPETNTSDPETLTEEAVLSFHNISY
                     RETVQSGFPLRQQTHVMERLSSISGIMGPGLNAIMGPQDGSRSLLLDVLAARRDPCGL
                     SGDILVNGKPQPANFKCTSGYVPQNDVIMHTVTVRDNLEFSAALRLPMTITRNEKRRR
                     INEVLELLHLEKEQNTKPRSKELRKRTSIAVELVTEHPILFLDDPTTGLDLRTTTDII
                     AVLRRMSKKGRTVIFSINQPQYSIFRFFDSLTLVASGKLMFHGPAQDALEYFTSAGYQ
                     YESHNNPADFFLDVINGGLCDTEEDGHEADEHEDLYERLHQVTEKLANMYAQSPLHSD
                     TRAKLDQLLGEQKQDRRSAMETTFVTPFWHQFGWITLRSFKNFKGFPWVTVIQAIIAV
                     ILAVFVGTIFRLLQNVCTEVKARAGLLFFLTGFECILSVSAGELFLLDRNHFLHEHTS
                     GYYRVSSYFFGKLLAELIPRRLLPSMIFTLITYFIAGMKTGVKGFFVTIFTVMMLASS
                     ASSLSLSLGAGENTAALPTTLITIYFMFMLFFSGLSLFSINFLPQLSWIQYLSIPHYG
                     FRALLHNEFLGQNFCPEHNTEEVSRCQNYVICTGEEFLQNLDIDSSSWGFWENHLALT
                     CIMIILLMISYVRLLRLKKRIHC"
     misc_feature    248..1990
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; Region: 3a01204; TIGR00955"
                     /db_xref="CDD:273361"
     misc_feature    248..1990
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; Region: 3a01204; TIGR00955"
                     /db_xref="CDD:273361"
     exon            262..321
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            322..436
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            437..589
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            590..726
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            727..878
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            879..971
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1219
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1302
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1392
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1517
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1672
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1762
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1848
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2002
                     /gene="Abcg3l3"
                     /gene_synonym="RGD1564709"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggactctgg cagaggctac aggctccttg ggcagcgcgg aaggaagaac ctctcaagat
       61 gtcttccagt aatgacccca ctgtaatacc aatggcagaa agacgttatg gtgaccttcc
      121 cgaaacaaac accagtgacc cggagacact gactgaagag gctgtgttga gttttcacaa
      181 catcagctac agagaaacag tgcagagcgg atttccactt cgtcagcaga cacatgtgat
      241 ggaaagactg tcgagcatca gtgggatcat gggacctggc ctcaatgcca ttatgggacc
      301 tcaggatggg agcagatctc tgttattaga tgtcttagct gcaaggagag acccgtgtgg
      361 attatcagga gatattttgg taaacggtaa acctcaacct gctaatttca aatgtacatc
      421 tggttatgta ccacaaaatg atgtgatcat gcacacggtg accgtgagag acaatttaga
      481 gttctcagca gctctccgtc ttccaatgac tataacaaga aatgaaaaaa gaaggaggat
      541 taatgaggtg cttgaacttc tgcatctgga aaaagaacaa aataccaagc ctagatccaa
      601 ggaactcagg aaaaggacca gtatagcagt ggagctggtc actgagcatc ccattttgtt
      661 cttggatgat cccaccactg gcttagactt gagaactaca actgatatca ttgcagtcct
      721 gagaaggatg tcgaagaagg gaaggacagt catcttctcc atcaatcagc ctcagtactc
      781 catcttcaga ttctttgata gcctcacctt agtggcttca ggaaaactca tgtttcatgg
      841 acctgcacag gatgctctgg agtacttcac atctgcaggt taccaatacg agtcccacaa
      901 caaccctgca gacttcttcc tggacgtcat taatggaggt ttgtgtgaca cagaggaaga
      961 tggccatgaa gctgacgaac atgaagacct ttatgagaga ctacatcaag tcacagaaaa
     1021 attggccaat atgtatgccc agtcaccctt acacagtgac acaagagcca aactggatca
     1081 actcttgggg gaacagaagc aggacaggag atcagctatg gagaccacat ttgtcacccc
     1141 tttctggcat cagttcgggt ggattaccct tcgatcattc aaaaatttca agggttttcc
     1201 atgggtcact gtgattcagg caattattgc agtcatactg gcggtgtttg tgggtaccat
     1261 tttccgtctc ctacaaaatg tttgtaccga agtcaaggca agagctgggc tgctcttctt
     1321 tctcacaggc tttgaatgta tcttaagtgt gtctgcaggg gagctcttcc tccttgacag
     1381 gaatcacttt ctacatgagc acaccagtgg atactacaga gtgtcatcct atttctttgg
     1441 aaaactgctg gctgagctaa tacccaggag gctgttgcca agtatgatat ttactcttat
     1501 aacatacttc atagcaggaa tgaaaacagg tgtcaagggt ttcttcgtta cgatatttac
     1561 tgtcatgatg ttggcgtctt ccgccagttc cctgtcccta tcgttaggag ctggagagaa
     1621 cacagctgct ctaccaacga ctctcataac catctacttt atgttcatgc tgtttttttc
     1681 aggtttatca ctattttcca taaacttcct gcctcagctc tcatggattc agtaccttag
     1741 catccctcat tatggattta gggctttgct gcacaatgag ttcctcggac aaaacttctg
     1801 tccagaacac aacacagaag aagtcagtag atgtcagaac tatgtaatat gcactggtga
     1861 agaattcttg caaaacctag acattgattc ctcatcctgg ggcttctggg agaatcacct
     1921 ggctttaacc tgtataatga ttatcctctt aatgatttct tatgtacgat tgctacgtct
     1981 taagaaaagg atacattgtt aa
//
LOCUS       NM_001008803            1482 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 82 (Krt82), mRNA.
ACCESSION   NM_001008803 XM_345876
VERSION     NM_001008803.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Rogers,M.A., Winter,H., Langbein,L., Wolf,C. and Schweizer,J.
  TITLE     Characterization of a 300 kbp region of human DNA containing the
            type II hair keratin gene domain
  JOURNAL   J Invest Dermatol 114 (3), 464-472 (2000)
   PUBMED   10692104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK003979.1.
            
            On Jan 5, 2005 this sequence version replaced XM_345876.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK003979.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMD00132285,
                                           SAMD00132286 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1482
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="keratin 82"
                     /db_xref="GeneID:366991"
                     /db_xref="RGD:1359276"
     CDS             1..1482
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="type II keratin Kb22; keratin 82, type II"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb2"
                     /protein_id="NP_001008803.1"
                     /db_xref="GeneID:366991"
                     /db_xref="RGD:1359276"
                     /translation="MPRMVTHYEVSKVPSRPGVGGGLRALGCLGSRSLCNVGFGRPRV
                     ASRCGMPGFGYRAGAACGSPACITPVTINESLLVPLELEIDPTVQSVKRDEKEQIKCL
                     NNRFASFINKVRFLEQKNKLLETKWNFMQQQRSCQSNMEPLFEGYICALRRQLDCVSG
                     DHGRLEAELCSLQEALEGYKKKYEEELSLRPCAENEFVTLKKDVDTAFLVKADLETNL
                     EALEHEIEFLKALFEEEISLLQSQISETSVIVKMDNSRDLDVDGIVAEIKAQYDDIAS
                     RSKAEAEAWYQCRYEELRMTAGNHSDNLRNRKNEILEMNKLIQRLQQDIETVKAQRCK
                     LEGAIAQAEQQGEAALSDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEI
                     ATYRRLLEGEEHRLCEGIGPVNISVSSSKGAVLYEPCVVGTPMLRTEYCTGATGVLRN
                     SGGCSVVGTGELYIPCEPQGLLGCGSGRSSSMKMGAGSNSCSH"
     misc_feature    <52..273
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="Keratin type II head; Region: Keratin_2_head;
                     pfam16208"
                     /db_xref="CDD:465068"
     misc_feature    <52..273
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="Keratin type II head; Region: Keratin_2_head;
                     pfam16208"
                     /db_xref="CDD:465068"
     misc_feature    283..1215
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    283..1215
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     exon            1..336
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            337..545
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            546..606
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            607..702
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            703..867
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            868..993
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1214
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1246
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1482
                     /gene="Krt82"
                     /gene_synonym="Kb22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccccgga tggtcaccca ctatgaagtg agcaaggtgc cctctcggcc cggggttggc
       61 gggggcctcc gagccctagg ctgccttggc tctcggagcc tatgcaacgt gggcttcggg
      121 agaccccgtg tggcctccag atgcggcatg ccaggcttcg ggtaccgagc gggagccgcc
      181 tgcggatctc ccgcctgcat cactcctgtc accatcaacg agagtctgct ggtccccctg
      241 gagctggaga ttgacccaac ggtgcaaagc gtgaagagag atgagaagga gcagatcaag
      301 tgcctgaata accgatttgc atccttcatc aacaaggtga ggttcttgga gcagaaaaac
      361 aagcttctgg agaccaagtg gaacttcatg cagcagcaga gaagttgcca gagcaacatg
      421 gagccactct tcgagggcta catctgcgcc ctgcggcgac agctggactg cgtgtctggg
      481 gaccatggca gactggaggc tgagctctgc agcctccagg aagcgctgga gggttataag
      541 aaaaagtatg aagaggaact gtccctgcgt ccctgtgctg agaatgagtt tgtcaccttg
      601 aagaaggatg tggacacagc cttcctggtg aaggctgacc tggaaaccaa cttggaggct
      661 ctagaacatg agattgagtt cctgaaagcc ctgtttgagg aggagatcag cctgcttcaa
      721 tctcagatct cggagacttc agtcatcgtg aagatggaca acagccggga tctggatgtg
      781 gacggcatcg tagccgagat caaggcccag tacgatgaca tcgccagccg cagcaaagca
      841 gaagcagagg cctggtacca gtgcaggtat gaggagctga ggatgacagc tgggaaccac
      901 agtgacaacc tacgaaaccg caagaacgag atcctggaaa tgaacaagct aatccagagg
      961 cttcagcagg acatcgaaac agtcaaagcc cagcgatgca aactcgaggg agccattgcc
     1021 caggcagagc agcaggggga ggctgccctc tctgacgcca agtgtaaact ggcagggctg
     1081 gaggaggcct tgcagaaggc caagcaggac atggcttgcc tgctcaagga gtaccaagag
     1141 gtgatgaact ccaagctggg gctggacatc gagatcgcca cctacaggcg cctgctggag
     1201 ggcgaggagc acaggttgtg tgaaggcatc gggcctgtga atatctctgt cagcagctcc
     1261 aaaggagccg ttctctatga gccctgtgtg gtgggcacgc ccatgctgag gaccgaatac
     1321 tgcaccgggg ccaccggtgt cctgaggaac agtgggggct gcagcgtggt gggcaccggt
     1381 gaactctaca tcccctgtga gccccaaggg ctcctgggct gtggaagtgg gcggagctcc
     1441 agcatgaaga tgggggcagg aagcaattca tgcagccact ga
//
LOCUS       NM_138850               2293 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus fibroblast activation protein, alpha (Fap), mRNA.
ACCESSION   NM_138850
VERSION     NM_138850.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Kilvaer,T.K., Rakaee,M., Hellevik,T., Ostman,A., Strell,C.,
            Bremnes,R.M., Busund,L.T., Donnem,T. and Martinez-Zubiaurre,I.
  TITLE     Tissue analyses reveal a potential immune-adjuvant function of
            FAP-1 positive fibroblasts in non-small cell lung cancer
  JOURNAL   PLoS One 13 (2), e0192157 (2018)
   PUBMED   29415055
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Tillmanns,J., Hoffmann,D., Habbaba,Y., Schmitto,J.D., Sedding,D.,
            Fraccarollo,D., Galuppo,P. and Bauersachs,J.
  TITLE     Fibroblast activation protein alpha expression identifies activated
            fibroblasts after myocardial infarction
  JOURNAL   J Mol Cell Cardiol 87, 194-203 (2015)
   PUBMED   26319660
  REMARK    GeneRIF: In this study, we show for the first time the expression
            of FAP in activated fibroblasts after MI and its activation by
            TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic
            activity indicate a potential role in cardiac wound healing
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Kilvaer,T.K., Khanehkenari,M.R., Hellevik,T., Al-Saad,S.,
            Paulsen,E.E., Bremnes,R.M., Busund,L.T., Donnem,T. and
            Martinez,I.Z.
  TITLE     Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic
            Impact and Their Correlations with Tumor Molecular Markers
  JOURNAL   PLoS One 10 (8), e0134965 (2015)
   PUBMED   26252379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Augoff,K., Hryniewicz-Jankowska,A., Tabola,R., Czapla,L.,
            Szelachowski,P., Wierzbicki,J., Grabowski,K. and Sikorski,A.F.
  TITLE     Upregulated expression and activation of membrane-associated
            proteases in esophageal squamous cell carcinoma
  JOURNAL   Oncol Rep 31 (6), 2820-2826 (2014)
   PUBMED   24789592
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Rowton,M., Ramos,P., Anderson,D.M., Rhee,J.M., Cunliffe,H.E. and
            Rawls,A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Park,J.E., Lenter,M.C., Zimmermann,R.N., Garin-Chesa,P., Old,L.J.
            and Rettig,W.J.
  TITLE     Fibroblast activation protein, a dual specificity serine protease
            expressed in reactive human tumor stromal fibroblasts
  JOURNAL   J Biol Chem 274 (51), 36505-36512 (1999)
   PUBMED   10593948
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Mueller,S.C., Ghersi,G., Akiyama,S.K., Sang,Q.X., Howard,L.,
            Pineiro-Sanchez,M., Nakahara,H., Yeh,Y. and Chen,W.T.
  TITLE     A novel protease-docking function of integrin at invadopodia
  JOURNAL   J Biol Chem 274 (35), 24947-24952 (1999)
   PUBMED   10455171
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Niedermeyer,J., Enenkel,B., Park,J.E., Lenter,M., Rettig,W.J.,
            Damm,K. and Schnapp,A.
  TITLE     Mouse fibroblast-activation protein--conserved Fap gene
            organization and biochemical function as a serine protease
  JOURNAL   Eur J Biochem 254 (3), 650-654 (1998)
   PUBMED   9688278
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Pineiro-Sanchez,M.L., Goldstein,L.A., Dodt,J., Howard,L., Yeh,Y.,
            Tran,H., Argraves,W.S. and Chen,W.T.
  TITLE     Identification of the 170-kDa melanoma membrane-bound gelatinase
            (seprase) as a serine integral membrane protease
  JOURNAL   J Biol Chem 272 (12), 7595-7601 (1997)
   PUBMED   9065413
  REMARK    Erratum:[J Biol Chem. 1998 May 22:273(21):13366]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF493782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF493782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2293
                     /gene="Fap"
                     /note="fibroblast activation protein, alpha"
                     /db_xref="GeneID:192203"
                     /db_xref="RGD:621253"
     exon            1..13
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2293
                     /gene="Fap"
                     /note="seprase"
                     /codon_start=1
                     /product="prolyl endopeptidase FAP"
                     /protein_id="NP_620205.1"
                     /db_xref="GeneID:192203"
                     /db_xref="RGD:621253"
                     /translation="MKTWLKTVFGVTTLVALALVVICIVLRPSRVYSPEGNTGRSLTL
                     KDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATD
                     YGLSPDRQFIYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGS
                     KLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDG
                     KYLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPIVRVFIVDTIYPHHVG
                     PIEVPVPEMIASSDYYFTWLTWVTNERVCLQWLKRVQNVSVLSICDFREDWHAWDCPK
                     NQEHIEESRTGWAGGFFVSTPAFSQDAASYYKIFSDKDGYKHIHYIKDTVENAIQITS
                     GKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQY
                     YTASFSYKAKYYALICYGPGLPISTLHDGRTDQEIQVLEENKELENALRNIQLPAVEI
                     KKLEDGGMTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFSVNWITYLASKEG
                     IVVALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEGRIAIWGWS
                     YGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYTERFMGLPTKDDNLEHYKNSTV
                     MARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGR
                     SQNHLYTHMTHFLKQCFSLSD"
     misc_feature    323..1426
                     /gene="Fap"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     Region: DPPIV_N; pfam00930"
                     /db_xref="CDD:395744"
     misc_feature    323..1426
                     /gene="Fap"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     Region: DPPIV_N; pfam00930"
                     /db_xref="CDD:395744"
     misc_feature    1664..2278
                     /gene="Fap"
                     /note="Prolyl oligopeptidase family; Region: Peptidase_S9;
                     pfam00326"
                     /db_xref="CDD:459761"
     misc_feature    1664..2278
                     /gene="Fap"
                     /note="Prolyl oligopeptidase family; Region: Peptidase_S9;
                     pfam00326"
                     /db_xref="CDD:459761"
     exon            14..98
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            99..197
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            198..292
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            293..367
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            368..420
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            421..493
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            494..614
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            615..769
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            770..873
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1009
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1054
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1159
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1230
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1284
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1409
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1457
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1556
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1626
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1821
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1876
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1976
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2041
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2114
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2188
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2293
                     /gene="Fap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaaaaatg aagacatggc tgaaaaccgt ctttggagtc actactttgg ttgcgcttgc
       61 tctagtggtg atatgcattg tcttacgtcc ctcaagagtt tacagccctg aaggcaacac
      121 aggaagatct cttaccctga aggatatttt aaatggaaca ttctcctata aaacatattt
      181 tccaaactgg atttcagagc aagaatatct tcatcaatct gaggatgata acatagtctt
      241 ttataatatt gaaacaagag aatcctatat cattttgagt aatagcacca tgaaaagtgt
      301 gaatgctaca gactatggcc tgtcacctga tcggcagttt atatatcttg aaagtgatta
      361 ttcaaagctc tggcgatatt catacacagc gacatactac atctacgacc ttcagaatgg
      421 ggaatttgta agaggatacg agctccctcg tccaattcag tatctgtgct ggtctcccgt
      481 tgggagtaaa ttagcatatg tctatcaaaa caatatttat ttaaaacaaa gaccaggaga
      541 tccacctttt caaataactt acactggaag agaaaataga atatttaatg gaattccaga
      601 ctgggtttat gaagaggaaa tgcttgctac aaaatatgcc ctttggtggt ccccagatgg
      661 aaaatatttg gcatatgtag aatttaatga ttcggacata ccaattattg cctactcgta
      721 ttatggcgat ggacagtatc ctagaactat aaatattcca tacccgaagg ccggagctaa
      781 gaatcccatt gttcgtgtct ttattgttga cactatctac ccacaccatg tgggtcctat
      841 agaagtacca gttccagaga tgatagcctc gagtgactac tatttcacct ggctcacatg
      901 ggtgaccaac gaacgagtat gtttgcagtg gctaaagaga gtgcagaatg tctcagtctt
      961 gtctatatgt gatttcagag aagactggca tgcgtgggat tgtccaaaga accaggagca
     1021 tattgaagaa agcagaacag gatgggctgg tggattcttt gtttccacac cagcttttag
     1081 ccaggatgcc gcttcatact acaaaatatt tagcgacaag gatggttaca aacatattca
     1141 ctacatcaaa gacactgtgg aaaatgctat tcaaattaca agtggcaagt gggaggccat
     1201 atatatattc cgagtaacac aggattcact gttttattct agcaatgaat ttgaaggtta
     1261 ccctggaaga agaaacatct acagaattag cattggaaac tctcctccga gtaagaagtg
     1321 tgttacttgc catctaagga aagaaaggtg ccaatattac acagcaagtt tcagctacaa
     1381 agccaaatac tatgcactca tctgctacgg ccctggcctc ccgatttcca ccctccatga
     1441 tggccgcaca gaccaagaaa tacaagtatt agaagagaac aaagaactgg agaacgctct
     1501 gagaaacatc cagctgcctg cagtggaaat taagaagctt gaagacggtg gaatgacttt
     1561 ctggtacaag atgattcttc ctcctcagtt tgacagatca aagaagtacc ctctgctaat
     1621 tcaagtgtat ggtggtccct gcagccagag tgtaaagtct gtattctctg ttaattggat
     1681 aacttatctt gcaagtaaag aggggatagt cgttgccttg gtagatggcc ggggcactgc
     1741 tttccaaggt gacaaattcc tgcatgccgt gtatcgaaag ctgggtgtgt atgaagttga
     1801 ggaccagctc acagctgtca gaaaattcat agaaatgggt ttcattgatg aaggaagaat
     1861 agccatatgg ggatggtcct acggaggtta tgtttcatcc ctagcccttg cgtccggaac
     1921 tggccttttc aaatgtggta tagcagtggc tccagtctcc agctgggaat actacgcctc
     1981 tatctacacg gagagattca tgggcctccc aacaaaggat gataatcttg aacactataa
     2041 aaattcaact gtgatggcaa gagcagaata tttcagaaat gtagactatc ttctcatcca
     2101 cggaacagca gatgataatg tgcactttca gaactcagca cagattgcta aagctttggt
     2161 taacgcacaa gtggatttcc aggcgatgtg gtactctgac cagaaccatg gcatatcatc
     2221 tgggcgctcc cagaaccact tatacactca catgacgcac ttcctcaagc aatgcttttc
     2281 tttatcagac tga
//
LOCUS       NM_175590               1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace-amine-associated receptor 7e (Taar7e),
            mRNA.
ACCESSION   NM_175590
VERSION     NM_175590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702322.1.
            
            On Jan 21, 2005 this sequence version replaced NM_175590.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="trace-amine-associated receptor 7e"
                     /db_xref="GeneID:294133"
                     /db_xref="RGD:631394"
     CDS             1..1077
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="taR-14; taR-7e; trace amine receptor 7e; trace
                     amine receptor 14"
                     /codon_start=1
                     /product="trace amine-associated receptor 7e"
                     /protein_id="NP_783180.2"
                     /db_xref="GeneID:294133"
                     /db_xref="RGD:631394"
                     /translation="MATDDASFPWDQDSILSRDLLSASSSQLCYENLNRSCIRSPYSP
                     GPRLILHAVFGFSAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADLLVGLTVMP
                     FSMVRSVEGCWYFGDIYCKFHSSFDVSFCYCSLFHLCFISVDRYIAVSDPLIYPTRFT
                     ASVSGKCITFSWFLSIIYSFSLLYTGASEAGLEDLVSALTCVGGCQLAVNQSWVFINF
                     LLFLVPTLVMMTVYSKVFLIAKQQAQNIEKIGKQTARASESYKDRVAKRERKAAKTLG
                     ITVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFR
                     KAIKLIVTGKILRENSSATNLFPE"
     misc_feature    100..102
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923X6.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    148..222
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..312
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    361..429
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    364..429
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    496..546
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    499..561
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..699
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..630
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923X6.1); glycosylation site"
     misc_feature    637..699
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    814..882
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    823..885
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    913..990
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    928..999
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923X6.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7e"
                     /gene_synonym="TA14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctacag atgatgccag ttttccctgg gatcaggaca gcatcctgag cagagatctg
       61 ctctcagcct cgtcttccca gctgtgctat gagaacctga acagatcctg catcaggagc
      121 ccatactccc caggccctcg cctcatcctc catgcagtct ttggctttag tgctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tgttggtggg tctgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttggaga catatattgt
      361 aaattccatt cttcttttga tgtttctttc tgctattgtt ctctcttcca cttgtgcttc
      421 atctctgttg atagatacat tgcagtcagt gaccccctga tctaccccac caggttcact
      481 gcatctgttt ctggcaagtg tatcaccttc tcctggttcc tgtccatcat ctacagcttt
      541 tccctccttt acacaggagc aagtgaagct gggctggagg atctagtgag tgccctcacc
      601 tgtgtgggcg gctgccaact tgcagtgaat caaagctggg tcttcatcaa tttcctattg
      661 tttcttgtcc ccacgcttgt gatgatgact gtctactcta aggtcttcct cattgcaaag
      721 cagcaggctc agaacatcga gaagattggc aagcagaccg ccagggcatc tgaaagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccctgggcat cacagtggct
      841 gctttcctcc tttcatggct gccatacttc attgactcca tcatcgatgc cttcctgggg
      901 ttcatcacgc ccacgtatgt gtatgaaatc ctagtttgga tagcttacta taactcagcc
      961 atgaaccctt tgatttatgc tttcttttat ccttggtttc gaaaagccat caaactcatt
     1021 gtcactggca aaatcttgag agagaattcc tcagccacca acctgtttcc tgagtag
//
LOCUS       NM_131908                627 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus fibroblast growth factor 6 (Fgf6), mRNA.
ACCESSION   NM_131908
VERSION     NM_131908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 627)
  AUTHORS   Cai,Q., Wu,G., Zhu,M., Ge,H., Xue,C., Zhang,Q., Cheng,B., Xu,S. and
            Wu,P.
  TITLE     FGF6 enhances muscle regeneration after nerve injury by relying on
            ERK1/2 mechanism
  JOURNAL   Life Sci 248, 117465 (2020)
   PUBMED   32105707
  REMARK    GeneRIF: FGF6 enhances muscle regeneration after nerve injury via
            ERK1/ERK2 activation.
REFERENCE   2  (bases 1 to 627)
  AUTHORS   Sautter,N.B., Delaney,K.L., Hausman,F.A. and Trune,D.R.
  TITLE     Tissue remodeling in the acute otitis media mouse model
  JOURNAL   Int J Pediatr Otorhinolaryngol 75 (11), 1368-1371 (2011)
   PUBMED   21889218
REFERENCE   3  (bases 1 to 627)
  AUTHORS   Ropiquet,F., Giri,D., Kwabi-Addo,B., Mansukhani,A. and Ittmann,M.
  TITLE     Increased expression of fibroblast growth factor 6 in human
            prostatic intraepithelial neoplasia and prostate cancer
  JOURNAL   Cancer Res 60 (15), 4245-4250 (2000)
   PUBMED   10945637
REFERENCE   4  (bases 1 to 627)
  AUTHORS   Kastner,S., Elias,M.C., Rivera,A.J. and Yablonka-Reuveni,Z.
  TITLE     Gene expression patterns of the fibroblast growth factors and their
            receptors during myogenesis of rat satellite cells
  JOURNAL   J Histochem Cytochem 48 (8), 1079-1096 (2000)
   PUBMED   10898801
REFERENCE   5  (bases 1 to 627)
  AUTHORS   Sakuma,K., Watanabe,K., Sano,M., Uramoto,I. and Totsuka,T.
  TITLE     Differential adaptation of growth and differentiation factor
            8/myostatin, fibroblast growth factor 6 and leukemia inhibitory
            factor in overloaded, regenerating and denervated rat muscles
  JOURNAL   Biochim Biophys Acta 1497 (1), 77-88 (2000)
   PUBMED   10838161
REFERENCE   6  (bases 1 to 627)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   7  (bases 1 to 627)
  AUTHORS   Grass,S., Arnold,H.H. and Braun,T.
  TITLE     Alterations in somite patterning of Myf-5-deficient mice: a
            possible role for FGF-4 and FGF-6
  JOURNAL   Development 122 (1), 141-150 (1996)
   PUBMED   8565825
REFERENCE   8  (bases 1 to 627)
  AUTHORS   deLapeyriere,O., Ollendorff,V., Planche,J., Ott,M.O., Pizette,S.,
            Coulier,F. and Birnbaum,D.
  TITLE     Expression of the Fgf6 gene is restricted to developing skeletal
            muscle in the mouse embryo
  JOURNAL   Development 118 (2), 601-611 (1993)
   PUBMED   8223280
REFERENCE   9  (bases 1 to 627)
  AUTHORS   Dinwiddie,S.H., Reich,T. and Cloninger,C.R.
  TITLE     Solvent use and psychiatric comorbidity
  JOURNAL   Br J Addict 85 (12), 1647-1656 (1990)
   PUBMED   2289066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB079674.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB079674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..627
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /note="fibroblast growth factor 6"
                     /db_xref="GeneID:170700"
                     /db_xref="RGD:620130"
     CDS             1..627
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /note="fibroblast growth factor 7b"
                     /codon_start=1
                     /product="fibroblast growth factor 6 precursor"
                     /protein_id="NP_571983.1"
                     /db_xref="GeneID:170700"
                     /db_xref="RGD:620130"
                     /translation="MALGQRLFITMSRGAGRVQGTLQALVFLGVLVGMVVPSPAGARA
                     NGTLLDSRGWGTLLSRSRAGLAGEISGVNWESGYLVGIKRQRRLYCNVGIGFHLQVPP
                     DGRISGTHEENPYSLLEISTVERGVVSLFGVKSALFIAMNSKGRLYTTPSFQDECKFR
                     ETLLPNNYNAYESDLYRGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI"
     sig_peptide     1..126
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    250..624
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 6 (FGF6) and similar proteins; Region:
                     beta-trefoil_FGF6; cd23318"
                     /db_xref="CDD:467004"
     misc_feature    250..624
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 6 (FGF6) and similar proteins; Region:
                     beta-trefoil_FGF6; cd23318"
                     /db_xref="CDD:467004"
     exon            1..346
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /inference="alignment:Splign:2.1.0"
     exon            347..450
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /inference="alignment:Splign:2.1.0"
     exon            451..627
                     /gene="Fgf6"
                     /gene_synonym="Fgf7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccctgg gacagaggct gttcatcact atgtcccggg gagcaggacg tgttcagggc
       61 acgctgcagg ctctcgtctt cttaggcgtc ctagtgggca tggtggtgcc ctcacctgcc
      121 ggcgcccgcg ccaacggcac gctactggac tccagaggct ggggcaccct cttgtccagg
      181 tctcgagctg ggctagctgg agagatttcg ggtgtgaatt gggaaagtgg ctatttggtg
      241 ggcattaagc gacagcggag actctactgc aacgtgggca ttggcttcca cctccaggtg
      301 cctcccgacg gccggatcag tgggacgcac gaggagaacc cctacagcct gctggaaatc
      361 tccacggtag aacggggtgt ggtgagcctc tttggtgtga aaagtgctct cttcattgcc
      421 atgaacagta aaggaagact gtacacaacg cccagcttcc aggacgaatg caagttcaga
      481 gaaaccctcc ttccaaacaa ctacaacgcc tacgagtccg acctgtacag agggacctac
      541 attgcactga gcaaatatgg acgggtaaag cggggcagca aggtgtcccc aatcatgact
      601 gtcactcact tcctccccag gatataa
//
LOCUS       NM_133400               1863 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus APOBEC1 complementation factor (A1cf), mRNA.
ACCESSION   NM_133400 XM_346579
VERSION     NM_133400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Rasheed,H., Stamp,L.K., Dalbeth,N. and Merriman,T.R.
  TITLE     Interaction of the GCKR and A1CF loci with alcohol consumption to
            influence the risk of gout
  JOURNAL   Arthritis Res Ther 19 (1), 161 (2017)
   PUBMED   28679452
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Dong,Z., Zhou,J., Jiang,S., Li,Y., Zhao,D., Yang,C., Ma,Y.,
            Wang,Y., He,H., Ji,H., Yang,Y., Wang,X., Xu,X., Pang,Y., Zou,H.,
            Jin,L. and Wang,J.
  TITLE     Effects of multiple genetic loci on the pathogenesis from serum
            urate to gout
  JOURNAL   Sci Rep 7, 43614 (2017)
   PUBMED   28252667
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Galloway,C.A., Ashton,J., Sparks,J.D., Mooney,R.A. and Smith,H.C.
  TITLE     Metabolic regulation of APOBEC-1 complementation factor trafficking
            in mouse models of obesity and its positive correlation with the
            expression of ApoB protein in hepatocytes
  JOURNAL   Biochim Biophys Acta 1802 (11), 976-985 (2010)
   PUBMED   20541607
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Galloway,C.A., Kumar,A., Krucinska,J. and Smith,H.C.
  TITLE     APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers
  JOURNAL   Biochem Biophys Res Commun 398 (1), 38-43 (2010)
   PUBMED   20541536
  REMARK    GeneRIF: N-terminal 320 amino acids of ACF retained RNA-binding
            selectivity and supported complementation of editing activity and
            in addition demonstrate a novel RNA-bridged multimerization of ACF.
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Sowden,M.P., Ballatori,N., Jensen,K.L., Reed,L.H. and Smith,H.C.
  TITLE     The editosome for cytidine to uridine mRNA editing has a native
            complexity of 27S: identification of intracellular domains
            containing active and inactive editing factors
  JOURNAL   J Cell Sci 115 (Pt 5), 1027-1039 (2002)
   PUBMED   11870221
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Mehta,A., Kinter,M.T., Sherman,N.E. and Driscoll,D.M.
  TITLE     Molecular cloning of apobec-1 complementation factor, a novel
            RNA-binding protein involved in the editing of apolipoprotein B
            mRNA
  JOURNAL   Mol Cell Biol 20 (5), 1846-1854 (2000)
   PUBMED   10669759
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Romanenko,A.V.
  TITLE     [Experience in the certification of veterinary specialists]
  JOURNAL   Veterinariia (12), 47-48 (1978)
   PUBMED   734901
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF290984.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346579.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="APOBEC1 complementation factor"
                     /db_xref="GeneID:170912"
                     /db_xref="RGD:619834"
     exon            1..57
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..201
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    91..93
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="upstream in-frame stop codon"
     CDS             103..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="APOBEC1-stimulating protein; APOBEC1
                     complementation factort; Apobec-1 complementation factor,
                     APOBEC-1 stimulating protein"
                     /codon_start=1
                     /product="APOBEC1 complementation factor"
                     /protein_id="NP_596891.1"
                     /db_xref="GeneID:170912"
                     /db_xref="RGD:619834"
                     /translation="MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPP
                     PGWDTTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVT
                     FSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVT
                     EGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEP
                     EVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNR
                     EDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQEYTYPLSHVY
                     DPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVRGAAGVRGLGGRGY
                     LAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQKNN
                     WGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEH
                     TLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYT
                     TYEVYPTFAVTTRGDGYGTF"
     misc_feature    106..1860
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    106..1860
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    1570..1572
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NQ94; propagated from
                     UniProtKB/Swiss-Prot (Q923K9.1); phosphorylation site"
     exon            202..336
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..467
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..706
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..871
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..969
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1240
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1422
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1559
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1711
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1863
                     /gene="A1cf"
                     /gene_synonym="A1cft; Acf; Apobec-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattcacca taatcaagaa accttttccg ggtgggggaa cctcagaaat tactcagtga
       61 gcaaccctaa ttaacctgat tttttgctga taatcactct caatggaatc aaatcacaaa
      121 tccggggatg gattgagcgg cacccagaag gaagcagcac tccgcgcact ggtccagcgc
      181 acaggatata gcttggtcca ggaaaatgga caaagaaaat atggtggtcc tccaccaggc
      241 tgggatacta cacccccaga aaggggctgc gagattttca ttgggaaact tccccgggac
      301 ctttttgagg atgaactcat accattgtgt gaaaaaattg gtaaaattta tgaaatgaga
      361 atgatgatgg atttcaatgg gaacaacaga ggctatgcat ttgtaacctt ctcaaataag
      421 caggaagcca agaatgcaat caagcaactt aataattatg aaattcggaa tggccgtctc
      481 ctgggcgtct gtgccagtgt ggacaactgc cggttgtttg tggggggaat ccccaaaacc
      541 aaaaagagag aagaaatctt gtcagagatg aaaaaggtca ctgaaggagt tgttgatgtc
      601 attgtctacc caagcgctgc cgataaaacc aaaaaccggg ggtttgcctt tgtggaatat
      661 gagagtcacc gcgcagccgc catggctagg cggaggctgc tgccaggaag aattcagttg
      721 tggggacatc ctatcgcagt agactgggca gagccagaag tcgaagttga cgaagacaca
      781 atgtcttccg tgaaaatcct gtacgtaagg aaccttatgc tgtctacctc ggaagagatg
      841 attgagaagg aattcaacag tattaaacca ggtgctgtgg aacgggtgaa gaagatccga
      901 gactatgctt ttgtgcattt cagtaaccga gaagatgcag ttgaagccat gaaggctttg
      961 aatggcaagg tgctggatgg ttccccaata gaagtgacct tggccaagcc agtggacaag
     1021 gacagttacg ttaggtacac ccggggcacc gggggcagga acaccatgct gcaagaatac
     1081 acctaccctc tgagccatgt ttatgaccct accacaacct accttggagc tcctgtcttc
     1141 tatactcccc aagcctacgc agccattcca agtcttcatt tcccagctac caaaggacat
     1201 ctcagcaaca gagctctcat ccggacccct tctgtcagag gggctgcggg cgtgagagga
     1261 ctgggcggcc gtgggtattt ggcatataca ggcctgggtc gaggatacca ggtcaaagga
     1321 gacaagagac aagacaaact ctatgacctt ctgcctggga tggagctcac cccgatgaat
     1381 actatctctt taaaaccaca aggagttaaa cttgctcctc agatattaga agaaatctgt
     1441 cagaaaaata actggggaca gccagtgtac cagctgcact ctgccattgg acaagaccaa
     1501 agacagttat tcctatacaa agtaactatc ccagcgctgg ccagccagaa tcctgcgatc
     1561 caccctttca cacccccaaa gctaagcgcc tacgtggatg aagcaaagag gtacgccgca
     1621 gagcacaccc tacagacact aggcatcccc acagaaggag gggacgctgg gactacagca
     1681 cccactgcca catccgccac tgtgtttcca ggatacgctg tccccagtgc caccgctcct
     1741 gtgtctacag cccagctcaa gcaagcagtg acacttggac aagacttagc agcatataca
     1801 acctatgagg tctaccctac ttttgcagtg accacccgag gtgatggata tggcaccttc
     1861 tga
//
LOCUS       NM_022202               2793 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus glutamate metabotropic receptor 8 (Grm8), mRNA.
ACCESSION   NM_022202 XM_347218
VERSION     NM_022202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Xie,Y., Chen,L., Chen,J., Luo,Y., Peng,Z., Zhang,H., Pan,Z. and
            Chen,Y.
  TITLE     Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in
            Microglia by Alleviating Endoplasmic Reticulum Stress and
            Mitochondrial Dysfunction
  JOURNAL   J Integr Neurosci 23 (2), 26 (2024)
   PUBMED   38419440
  REMARK    GeneRIF: Metabotropic Glutamate Receptor 8 Suppresses M1
            Polarization in Microglia by Alleviating Endoplasmic Reticulum
            Stress and Mitochondrial Dysfunction.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Katona,L., Hartwich,K., Tomioka,R., Somogyi,J., Roberts,J.D.B.,
            Wagner,K., Joshi,A., Klausberger,T., Rockland,K.S. and Somogyi,P.
  TITLE     Synaptic organisation and behaviour-dependent activity of
            mGluR8a-innervated GABAergic trilaminar cells projecting from the
            hippocampus to the subiculum
  JOURNAL   Brain Struct Funct 225 (2), 705-734 (2020)
   PUBMED   32016558
  REMARK    GeneRIF: Synaptic organisation and behaviour-dependent activity of
            mGluR8a-innervated GABAergic trilaminar cells projecting from the
            hippocampus to the subiculum.
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Carmichael,R.E., Wilkinson,K.A., Craig,T.J., Ashby,M.C. and
            Henley,J.M.
  TITLE     MEF2A regulates mGluR-dependent AMPA receptor trafficking
            independently of Arc/Arg3.1
  JOURNAL   Sci Rep 8 (1), 5263 (2018)
   PUBMED   29588465
  REMARK    GeneRIF: This study shows via knockdown of endogenous MEF2A in
            primary neuronal culture, that MEF2A is specifically required for
            Group I metabotropic glutamate receptor (mGluR)-mediated GluA2
            internalisation, but does not regulate AMPAR expression or
            trafficking under basal conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Govea,R.M., Zhou,S. and Carlton,S.M.
  TITLE     Group III mGluR8 negatively modulates TRPA1
  JOURNAL   Neuroscience 334, 134-147 (2016)
   PUBMED   27497709
  REMARK    GeneRIF: Results show that group III mGluRs negatively modulate
            TRPA1 activity on cutaneous nociceptors. Furthermore, it is likely
            that this modulation occurs intracellularly at the level of the
            cAMP/PKA pathway. This study demonstrates that group III agonists
            may be effective in the treatment of mechanical hypersensitivity
            which can develop as a result of inflammation, nerve injury,
            chemotherapy and other disease states.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Long,E.C., Aliev,F., Wang,J.C., Edenberg,H.J., Nurnberger,J. Jr.,
            Hesselbrock,V., Porjesz,B. and Dick,D.M.
  TITLE     Further Analyses of Genetic Association Between GRM8 and Alcohol
            Dependence Symptoms Among Young Adults
  JOURNAL   J Stud Alcohol Drugs 76 (3), 414-418 (2015)
   PUBMED   25978827
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Corti,C., Restituito,S., Rimland,J.M., Brabet,I., Corsi,M.,
            Pin,J.P. and Ferraguti,F.
  TITLE     Cloning and characterization of alternative mRNA forms for the rat
            metabotropic glutamate receptors mGluR7 and mGluR8
  JOURNAL   Eur J Neurosci 10 (12), 3629-3641 (1998)
   PUBMED   9875342
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Shigemoto,R., Kinoshita,A., Wada,E., Nomura,S., Ohishi,H.,
            Takada,M., Flor,P.J., Neki,A., Abe,T., Nakanishi,S. and Mizuno,N.
  TITLE     Differential presynaptic localization of metabotropic glutamate
            receptor subtypes in the rat hippocampus
  JOURNAL   J Neurosci 17 (19), 7503-7522 (1997)
   PUBMED   9295396
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Saugstad,J.A., Kinzie,J.M., Shinohara,M.M., Segerson,T.P. and
            Westbrook,G.L.
  TITLE     Cloning and expression of rat metabotropic glutamate receptor 8
            reveals a distinct pharmacological profile
  JOURNAL   Mol Pharmacol 51 (1), 119-125 (1997)
   PUBMED   9016353
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Duvoisin,R.M., Zhang,C. and Ramonell,K.
  TITLE     A novel metabotropic glutamate receptor expressed in the retina and
            olfactory bulb
  JOURNAL   J Neurosci 15 (4), 3075-3083 (1995)
   PUBMED   7722646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U63288.1.
            
            On Dec 17, 2003 this sequence version replaced XM_347218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="glutamate metabotropic receptor 8"
                     /db_xref="GeneID:60590"
                     /db_xref="RGD:619858"
     exon            1..576
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="G protein-coupled receptor, family C, group 1,
                     member H; metabotropic glutamate receptor subtype 8b;
                     metabotropic glutamate receptor 8; glutamate receptor,
                     metabotropic 8"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 8 precursor"
                     /protein_id="NP_071538.1"
                     /db_xref="GeneID:60590"
                     /db_xref="RGD:619858"
                     /translation="MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDG
                     DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI
                     LDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI
                     MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYV
                     STLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR
                     AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPK
                     RASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIAR
                     DSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVN
                     FNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANRE
                     HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINR
                     TGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYV
                     LLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKK
                     SVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVL
                     KCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFI
                     PIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF
                     KAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI"
     sig_peptide     67..165
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1)"
     mat_peptide     166..2790
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /product="Metabotropic glutamate receptor 8.
                     /id=PRO_0000012943"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1)"
     misc_feature    184..1578
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="ligand-binding domain of the group III metabotropic
                     glutamate receptor; Region: PBP1_mGluR_groupIII; cd06376"
                     /db_xref="CDD:380599"
     misc_feature    184..1578
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="ligand-binding domain of the group III metabotropic
                     glutamate receptor; Region: PBP1_mGluR_groupIII; cd06376"
                     /db_xref="CDD:380599"
     misc_feature    order(223..225,268..270,277..279,526..528,532..534,
                     742..747)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:380599"
     misc_feature    order(223..225,268..270,277..279,526..528,532..534,
                     742..747)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:380599"
     misc_feature    349..351
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1); glycosylation site"
     misc_feature    order(394..396,403..405,547..549,556..558,625..627,
                     820..822)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380599"
     misc_feature    order(394..396,403..405,547..549,556..558,625..627,
                     820..822)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380599"
     misc_feature    958..960
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1); glycosylation site"
     misc_feature    1420..1422
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1); glycosylation site"
     misc_feature    1504..1506
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1); glycosylation site"
     misc_feature    1600..1752
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1600..1752
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1759..1761
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70579.1); glycosylation site"
     misc_feature    1810..2742
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="metabotropic glutamate receptor 8 in group 3,
                     member of the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_mGluR8; cd15454"
                     /db_xref="CDD:320570"
     misc_feature    1810..2742
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="metabotropic glutamate receptor 8 in group 3,
                     member of the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_mGluR8; cd15454"
                     /db_xref="CDD:320570"
     misc_feature    1810..1887
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320570"
     misc_feature    1810..1887
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320570"
     misc_feature    1816..1890
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    order(1819..1821,1828..1833,1840..1845,1849..1854,
                     1954..1956,1966..1968,1975..1980,2002..2004,2014..2016)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320570"
     misc_feature    order(1819..1821,1828..1833,1840..1845,1849..1854,
                     1954..1956,1966..1968,1975..1980,2002..2004,2014..2016)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320570"
     misc_feature    1921..1986
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320570"
     misc_feature    1921..1986
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320570"
     misc_feature    1927..1989
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    order(1981..1983,2017..2022,2029..2034,2041..2043,
                     2296..2298,2311..2313,2320..2325,2332..2334,2434..2436,
                     2443..2448,2455..2457,2467..2469,2506..2511,2518..2520,
                     2527..2529,2539..2541)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320570"
     misc_feature    order(1981..1983,2017..2022,2029..2034,2041..2043,
                     2296..2298,2311..2313,2320..2325,2332..2334,2434..2436,
                     2443..2448,2455..2457,2467..2469,2506..2511,2518..2520,
                     2527..2529,2539..2541)
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320570"
     misc_feature    2008..2070
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    2011..2085
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320570"
     misc_feature    2011..2085
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320570"
     misc_feature    2149..2211
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320570"
     misc_feature    2149..2211
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320570"
     misc_feature    2152..2214
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    2299..2379
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320570"
     misc_feature    2299..2379
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320570"
     misc_feature    2305..2370
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    2401..2472
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320570"
     misc_feature    2401..2472
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320570"
     misc_feature    2410..2475
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     misc_feature    2500..2577
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320570"
     misc_feature    2500..2577
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320570"
     misc_feature    2521..2595
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /note="propagated from UniProtKB/Swiss-Prot (P70579.1);
                     transmembrane region"
     exon            577..793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            794..929
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1084
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1222
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1423
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1560
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2496
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2743
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2793
                     /gene="Grm8"
                     /gene_synonym="Glur8; Gprc1h; mGlur; Mglur8; mGluR8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctacccctt cttctgtggc aagaataaac ttctggtcgc tgactgcaat accccccgtg
       61 gagaaaatgg tatgcgaggg aaagcgctta gcctcttgcc cttgcttctt cctcttgact
      121 gccaagttct actggatcct cacaatgatg caaagaactc acagccaaga gtatgcccat
      181 tccatccggg tggatgggga catcattttg gggggtcttt ttcctgttca tgccaaggga
      241 gaaagagggg tgccttgtgg ggagctgaag aaggaaaagg ggatccacag acttgaggcc
      301 atgctttatg caatcgacca gattaacaaa gaccctgatc ttctctccaa tatcactctg
      361 ggggtccgga tccttgacac gtgttccagg gacacctacg ctttggagca gtcactgacc
      421 ttcgtgcagg cactgataga gaaagatgcg tctgatgtga agtgtgctaa tggagatccg
      481 cccatattca ccaagcccga caagatttct ggcgtcatag gtgctgcagc aagctctgtg
      541 tccatcatgg tggctaacat tttaagacta tttaagatac ctcagattag ctatgcatcc
      601 acagccccag agctaagtga caacaccagg tatgatttct tttctcgggt ggtcccgcct
      661 gactcctacc aagcccaagc catggtggac attgtgacgg ccctgggatg gaattatgtg
      721 tcaacactgg cttccgaggg gaactatgga gagagtggtg ttgaggcctt cactcagatc
      781 tcaagggaga ttggtggtgt ttgcattgct caatcacaga aaatcccacg tgaaccaaga
      841 cctggggaat ttgaaaaaat tatcaaacgc ctgctggaga cacctaacgc tcgcgcagtg
      901 attatgtttg ccaacgagga tgacatcagg aggatattgg aagcagcaaa aaaattaaac
      961 cagagtgggc attttctatg gattggctct gatagttggg gatccaaaat tgcgcccgtc
     1021 taccagcagg aggagatcgc agaaggagcg gtgacaattt tgcctaaaag agcatcaatt
     1081 gatgggtttg atcgatactt tagaagccga actcttgcta ataatcgaag aaatgtgtgg
     1141 tttgcagaat tttgggagga gaattttgga tgcaaattag gatcacatgg gaagaggaac
     1201 agtcacataa agaaatgcac agggctggag cgaattgcac gggattcatc ttatgaacaa
     1261 gaaggaaagg ttcaatttgt tattgatgca gtgtattcca tggcttatgc actgcataac
     1321 atgcacaaag agcgctgtcc tggatacata ggtctttgcc caagaatggt caccatcgat
     1381 gggaaagagc tactgggtta catcagggcc gtgaatttta atggcagtgc tggtacacct
     1441 gtcactttta atgaaaatgg agatgctcct ggacgctacg atatcttcca gtatcagata
     1501 aacaacaaaa gtacagagta caaaatcatc gggcactgga caaatcaact tcatctaaag
     1561 gtggaagata tgcagtgggc taatagagag cacacgcacc cagcatctgt ctgcagcctg
     1621 ccgtgcaagc ccggggagag gaagaaaacc gtgaaagggg tcccttgctg ctggcactgt
     1681 gaacgttgtg agggttataa ctaccaggtg gatgaactgt cctgtgaact ttgccctttg
     1741 gatcagagac caaacatcaa ccgcacaggc tgccagagga tccccatcat caagttggag
     1801 tggcattcgc cctgggctgt ggtacctgtg ttcatagcaa tattgggaat cattgctacc
     1861 acctttgtga ttgtgacctt tgtccgctat aatgacacgc ccatcgtgag agcttctggg
     1921 cgggaactta gttacgtgct cctaacgggg atttttctct gttactccat cacctttttg
     1981 atgattgccg cacctgacac gatcatctgc tccttccgac ggatcttctt gggacttggt
     2041 atgtgtttca gctatgcagc acttttgacc aaaacaaacc gtatccaccg aatattcgag
     2101 caagggaaga aatctgtcac agcacctaag tttatcagcc cagcatccca actggtgatc
     2161 accttcagcc tcatctctgt ccagctcctc ggagtgtttg tgtggtttgt cgtggatccc
     2221 ccccacacca tcattgacta tggcgaacag cgaacgctgg atcctgagaa cgccagggga
     2281 gtgctcaagt gtgatatttc ggatctgtca ctcatttgtt ccctgggata cagtatcctc
     2341 ctgatggtca cctgtactgt ttatgccatt aaaaccagag gggtcccaga gacgttcaat
     2401 gaagccaaac ctattggctt tacaatgtac accacgtgca tcatttggtt agctttcatc
     2461 cccatctttt ttggtacagc ccagtcagca gaaaagatgt acatccagac aacgacactt
     2521 actgtttcca tgagtttaag tgcttcagtg tctctgggaa tgctctatat gcccaaagtt
     2581 tatattataa tttttcatcc agagcagaat gttcaaaaac gcaagagaag cttcaaggct
     2641 gtggtcacag ctgctaccat gcaaagcaaa ctgatccaaa agggaaatga cagaccaaat
     2701 ggcgaggtga aaagtgaact ctgtgagagt cttgaaacca acacgtcttc taccaagaca
     2761 acatacatca gctacagtaa tcattcgatc tga
//
LOCUS       NM_175601               1035 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 8B (Taar8b),
            mRNA.
ACCESSION   NM_175601
VERSION     NM_175601.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380195.1.
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1035
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="trace amine-associated receptor 8B"
                     /db_xref="GeneID:319106"
                     /db_xref="RGD:631386"
     CDS             1..1035
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="taR-7; taR-8b; trace amine receptor 8b; trace amine
                     receptor 7"
                     /codon_start=1
                     /product="trace amine-associated receptor 8b"
                     /protein_id="NP_783191.1"
                     /db_xref="GeneID:319106"
                     /db_xref="RGD:631386"
                     /translation="MTSNFSQATLQLCYENVNASCIKTPYSPGLRVLLYMVFGFGAVL
                     AVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESCWYFGDT
                     FCSLHSCCDAAFCYSSLFHLCFISVDRYIAVTEPLVYPTKFTMSVSGICISISWILPL
                     VYSSAVFYTGISATGIENLVSALNCVGGCQVAINQDWVLISFLLFFIPTLVMIILYSK
                     IFLVAKQQAVKIETSISGSKGESSLESHKARVAKRERKAAKTLGVTVMAFMVSWLPYT
                     IDTLIDAFMGFITPAYVYEICGWIAYYNSAMNPLIYAFFYPWFRKAIKLILSGKILKG
                     HSSTTSLFSE"
     misc_feature    10..12
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y3.1); glycosylation site"
     misc_feature    52..54
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y3.1); glycosylation site"
     misc_feature    94..969
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    94..969
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    100..174
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    100..174
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    100..162
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    199..267
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    199..267
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    202..264
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    307..381
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    313..381
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    313..381
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    439..501
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    448..498
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    448..498
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    580..651
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    580..651
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    589..651
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    769..831
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     misc_feature    772..840
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    772..840
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    871..948
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    871..948
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    886..957
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y3.1);
                     transmembrane region"
     exon            1..1035
                     /gene="Taar8b"
                     /gene_synonym="Ta7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacaagca acttttccca agcaaccctg cagctctgct atgagaatgt gaatgcttcc
       61 tgcattaaaa ccccctattc accagggctc cgggtcctcc tgtacatggt ctttggcttt
      121 ggggctgtgc tggcagtgtg tgggaacctc ctggtggtga tttcagtcct ccatttcaag
      181 cagctgcact ctcctgccaa tttcctcatc gcctccctgg ccagtgctga cttcttggtg
      241 ggcatctctg tgatgccctt cagcatggtc aggtccatcg agagctgctg gtactttgga
      301 gacacatttt gtagccttca cagctgctgt gatgcagcat tttgctactc ttctcttttc
      361 cacctctgtt tcatctctgt ggacaggtac atcgctgtca cggaacctct ggtctatccc
      421 accaagttca caatgtctgt gtctggaatt tgcatcagca tctcctggat tctgcccctt
      481 gtgtacagca gcgcagtatt ctacacaggc atcagtgcta cggggattga aaacctagta
      541 agtgctctca actgtgtagg aggctgccaa gttgcgatca atcaagactg ggttttgata
      601 agttttctct tattcttcat acctaccctt gttatgatca tcctctacag caaaatattt
      661 ttagtagcca aacagcaagc tgtaaaaatt gaaacttcta taagtggaag caaaggagaa
      721 tcgtccttag agagtcacaa agccagggtg gccaagagag agaggaaggc tgccaaaacc
      781 ttgggggtca ctgtcatggc atttatggtc tcatggctac catatacaat tgacaccttg
      841 attgatgctt tcatgggctt catcactcct gcctatgtct atgaaatttg tggctggatc
      901 gcttattata actcagccat gaaccctttg atttatgctt tcttttaccc ttggtttagg
      961 aaagccataa agctcatttt aagtgggaaa attttaaagg gtcattcatc aactactagt
     1021 ttgttttcag aataa
//
LOCUS       NM_001267781             327 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed 2 (Pate2), mRNA.
ACCESSION   NM_001267781 XM_002729927 XM_003754399
VERSION     NM_001267781.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Rajesh,A. and Yenugu,S.
  TITLE     Genomic organization, tissue distribution and functional
            characterization of the rat Pate gene cluster
  JOURNAL   PLoS One 7 (3), e32633 (2012)
   PUBMED   22479333
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Levitin,F., Weiss,M., Hahn,Y., Stern,O., Papke,R.L., Matusik,R.,
            Nandana,S.R., Ziv,R., Pichinuk,E., Salame,S., Bera,T., Vincent,J.,
            Lee,B., Pastan,I. and Wreschner,D.H.
  TITLE     PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR
            proteins that are expressed in reproductive and neuron-rich tissues
            and possess neuromodulatory activity
  JOURNAL   J Biol Chem 283 (24), 16928-16939 (2008)
   PUBMED   18387948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from HQ687476.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003754399.1, XM_002729927.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ687476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840127 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..327
                     /gene="Pate2"
                     /note="prostate and testis expressed 2"
                     /db_xref="GeneID:100361465"
                     /db_xref="RGD:2320100"
     CDS             1..327
                     /gene="Pate2"
                     /codon_start=1
                     /product="prostate and testis expressed protein 2"
                     /protein_id="NP_001254710.1"
                     /db_xref="GeneID:100361465"
                     /db_xref="RGD:2320100"
                     /translation="MLVIVCLFCQYWGVLNEPEKDLGTMCYKCKKYHLGLCYGLMRSC
                     TLKHRQSCAAENFYILTNRGQSMYHYSRLSCMTNCEDINFLSFERRTELICCKHSSYC
                     NLPMGL"
     misc_feature    67..309
                     /gene="Pate2"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 2 (PATE2) and similar proteins;
                     Region: TFP_LU_ECD_PATE2; cd23578"
                     /db_xref="CDD:467108"
     misc_feature    67..309
                     /gene="Pate2"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 2 (PATE2) and similar proteins;
                     Region: TFP_LU_ECD_PATE2; cd23578"
                     /db_xref="CDD:467108"
     exon            1..37
                     /gene="Pate2"
                     /inference="alignment:Splign:2.1.0"
     exon            38..61
                     /gene="Pate2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..190
                     /gene="Pate2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..327
                     /gene="Pate2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctggtga tagtctgttt gttctgccag tattggggtg tccttaatga acctgaaaaa
       61 gatcttggaa caatgtgtta taaatgtaag aaatatcatc ttgggttatg ctacggactc
      121 atgagatcct gcacactgaa gcatagacag tcctgtgctg ctgagaactt ttacatactc
      181 acgaacagag ggcagagcat gtatcattat tcaagactgt catgtatgac caactgtgag
      241 gacatcaact tcctgagttt tgaaaggagg acagagctaa tttgttgcaa gcacagtagc
      301 tattgcaacc tcccaatggg actctag
//
LOCUS       NM_001166677            1002 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 110 (Tas2r110),
            mRNA.
ACCESSION   NM_001166677
VERSION     NM_001166677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   3  (bases 1 to 1002)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   4  (bases 1 to 1002)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   5  (bases 1 to 1002)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   6  (bases 1 to 1002)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362732.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1002
                     /gene="Tas2r110"
                     /note="taste receptor, type 2, member 110"
                     /db_xref="GeneID:100310875"
                     /db_xref="RGD:2314263"
     CDS             1..1002
                     /gene="Tas2r110"
                     /note="T2R10; T2R110; taste receptor type 2 member 10"
                     /codon_start=1
                     /product="taste receptor type 2 member 110"
                     /protein_id="NP_001160149.1"
                     /db_xref="GeneID:100310875"
                     /db_xref="RGD:2314263"
                     /translation="MFLHTIKQRDIFTLIIIFFVEITMGILGNGFIALVNIVDWIKRR
                     RISSVDKILTTLALTRLIYAWSMLIFILLFILGPHLIMRSEILTSMGVIWVVNNHFSI
                     WLATCLGVFYFLKIANFSNSLFLYLKWRVKKVVLMIIVVSLIFLILNIFSLEIYDHFS
                     IDVYEGNMSYSLGDSTHFPRIFLFANSSKVFLITNSSQVFLPINSLFMLIPFTVSLVA
                     FFMLIFSLWKHHKKMEVNAKGPRDASTTAHIKALQTGLSFLLLYAIYLLFIVIGILSH
                     KFMGGKLILIFDHICAIVFPISHSFVLILGNSKLRRSTLSVLRFLRCRSKHIHIMDP"
     misc_feature    37..954
                     /gene="Tas2r110"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    37..954
                     /gene="Tas2r110"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    37..114
                     /gene="Tas2r110"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    37..114
                     /gene="Tas2r110"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    43..105
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    148..222
                     /gene="Tas2r110"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    148..222
                     /gene="Tas2r110"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    181..243
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    262..330
                     /gene="Tas2r110"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    262..330
                     /gene="Tas2r110"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    271..333
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    403..465
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    409..459
                     /gene="Tas2r110"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    409..459
                     /gene="Tas2r110"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    499..501
                     /gene="Tas2r110"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKE8.2); glycosylation site"
     misc_feature    535..660
                     /gene="Tas2r110"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    535..660
                     /gene="Tas2r110"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    556..558
                     /gene="Tas2r110"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKE8.2); glycosylation site"
     misc_feature    583..585
                     /gene="Tas2r110"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKE8.2); glycosylation site"
     misc_feature    616..678
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    733..810
                     /gene="Tas2r110"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    733..810
                     /gene="Tas2r110"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    760..822
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     misc_feature    844..921
                     /gene="Tas2r110"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    844..921
                     /gene="Tas2r110"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    850..912
                     /gene="Tas2r110"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE8.2);
                     transmembrane region"
     exon            1..1002
                     /gene="Tas2r110"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcttac acacaataaa gcaacgtgat atttttactt tgataatcat attttttgtg
       61 gaaataacaa tgggaatctt aggaaatgga ttcatagcac tagtgaatat tgtggactgg
      121 atcaagagaa gaaggatttc ttcagtggat aagattctca ctaccttggc ccttaccaga
      181 ctcatttatg cgtggtctat gctcattttt atattgttat tcatactggg cccgcatttg
      241 attatgagat cagaaatact tacatcaatg ggtgttatct gggtggtgaa caatcacttc
      301 agcatctggc ttgctacatg cctcggtgtc ttttattttc tcaagatagc caatttttct
      361 aactctttgt ttctttacct aaagtggaga gttaaaaaag tggttttaat gataatagta
      421 gtgtcattga ttttcttgat attaaacatt ttttcattag agatttatga tcatttctca
      481 attgatgttt atgaaggaaa tatgtcttat agcttggggg attcaacaca ttttcccaga
      541 attttcttat tcgcaaactc atctaaggtc ttcttaatca ccaattcatc ccaggttttc
      601 ttacccatca actcactctt catgctcata cccttcacag tttccctggt agcttttttc
      661 atgcttatct tctcactgtg gaagcatcac aagaagatgg aggtcaatgc caaaggaccc
      721 agagatgcca gcaccacggc ccacattaaa gctttacaaa ctgggctctc cttcctgctg
      781 ctgtatgcaa tatacttact ttttattgtc ataggaattt tgagtcataa atttatgggg
      841 gggaaattga tactcatatt tgaccacatt tgtgcaatag tttttcctat aagccactca
      901 tttgtgctga ttctgggaaa tagtaaactg agacgaagca ctctttctgt gctgcgtttt
      961 ctgaggtgcc gatccaagca tatacacatc atggatccct aa
//
LOCUS       NM_001107012            2055 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 1 (Tnk1), mRNA.
ACCESSION   NM_001107012 XM_001079627 XM_220614
VERSION     NM_001107012.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Hoare,K., Hoare,S., Smith,O.M., Kalmaz,G., Small,D. and Stratford
            May,W.
  TITLE     Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
  JOURNAL   Oncogene 22 (23), 3562-3577 (2003)
   PUBMED   12789265
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Felschow,D.M., Civin,C.I. and Hoehn,G.T.
  TITLE     Characterization of the tyrosine kinase Tnk1 and its binding with
            phospholipase C-gamma1
  JOURNAL   Biochem Biophys Res Commun 273 (1), 294-301 (2000)
   PUBMED   10873601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220614.4, XM_001079627.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2055
                     /gene="Tnk1"
                     /note="tyrosine kinase, non-receptor, 1"
                     /db_xref="GeneID:303247"
                     /db_xref="RGD:1310113"
     exon            1..214
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2055
                     /gene="Tnk1"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TNK1"
                     /protein_id="NP_001100482.1"
                     /db_xref="GeneID:303247"
                     /db_xref="RGD:1310113"
                     /translation="MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPE
                     DLDNLGMGRPAQRRLTEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPYSDSLPHLHE
                     PEGGLKCLIPEGAVCRGELLGSGCFGVVHQGLWTLPGGQSIPVAVKSLRVGPEGPMGT
                     ELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPMPPLP
                     VTLLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRKIKVADFGLVRPLGGARGR
                     YVMGGPRPIPYAWCAPESLRQGAFSAASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQ
                     RLEKDRARLPKPALCSRALYSLALRCWAPHPADRPTFSNLEGLLQEAWLSEGRCVREV
                     TEPGALRMEPGDPITIIEGSPDTTTWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPV
                     HRGSPARGEKYRGGTDGDREKAVLQDLPPARNQRRKVPLQRMKGISKSLESVLSLGPR
                     PAGGGSSPPELRRGCTRAWPQGLADLPPRPPDLPPRPPIICSSQPIQPHRVRPKREPL
                     HNHCTGAPGSSKVTIPPGGPLSDSEWQRKIVEVELSVHGVTYQECQMALRTMGGDVAS
                     AIRNLKVDQLFHLSNRSRADCRRILEHHHWDLSAASRYVLARS"
     misc_feature    97..252
                     /gene="Tnk1"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    97..252
                     /gene="Tnk1"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    409..1191
                     /gene="Tnk1"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    409..1191
                     /gene="Tnk1"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(415..426,433..435,439..441,487..489,493..495,
                     592..594,637..648,784..786,796..801,805..807,835..840)
                     /gene="Tnk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(415..426,433..435,439..441,487..489,493..495,
                     592..594,637..648,784..786,796..801,805..807,835..840)
                     /gene="Tnk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    <1234..1359
                     /gene="Tnk1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    <1234..1359
                     /gene="Tnk1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    1834..1965
                     /gene="Tnk1"
                     /note="UBA domain-like superfamily; Region: UBA_like_SF;
                     cl21463"
                     /db_xref="CDD:473871"
     misc_feature    1834..1965
                     /gene="Tnk1"
                     /note="UBA domain-like superfamily; Region: UBA_like_SF;
                     cl21463"
                     /db_xref="CDD:473871"
     misc_feature    1924..2043
                     /gene="Tnk1"
                     /note="UBA domain-like superfamily; Region: UBA_like_SF;
                     cl21463"
                     /db_xref="CDD:473871"
     misc_feature    1924..2043
                     /gene="Tnk1"
                     /note="UBA domain-like superfamily; Region: UBA_like_SF;
                     cl21463"
                     /db_xref="CDD:473871"
     exon            215..285
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..477
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..633
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..917
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1191
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1286
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1451
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1531
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1845
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1941
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2055
                     /gene="Tnk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctatccatt taaagcagac tgccgtcctc cggagaggtc taaccccaga catgctcccc
       61 gaagccagtt ccctgtggct ccttcggctg ctccgggacg tccagctggc ccagttctac
      121 cggcccatcc ttgaggaact caacgtcact cggccagaac attttgactt tgtaaggcct
      181 gaggacctgg acaaccttgg catgggcagg cctgcccaac gaagacttac tgaagccctg
      241 aagaggtacc gttcgggggt caagtctaag aactgggtgt acaagatact tgggggtttt
      301 gctcctgaac agaaggagat ccctccatac tcagacagtc ttccacacct ccatgagcca
      361 gaggggggac tcaagtgtct gattccagag ggtgctgtgt gcagagggga actgctgggt
      421 tcaggctgct ttggtgttgt acatcaaggg ctatggacac tacccggtgg tcaaagtatc
      481 ccagtggctg tcaagtccct ccgtgtgggt cccgagggtc cgatgggcac agaactggga
      541 gacttcctgc gggaagtgtc tgtcatgatg aaactggagc acccacatgt gctgcgcctg
      601 catggcctcg tactgggcca gcctctacag atggtgatgg aacttgcgcc actgggttcc
      661 ctgcatgcgc gcctgactgc cccagcaccg atgcccccac tgcctgtaac cctactgtgc
      721 ctttttctgc gtcagttggc aggagccatg gcgtacttgg ggtcctgtgg gttagtgcac
      781 agggatcttg ctacccgtaa cctcctgcta gcctcacctc ggaagatcaa ggtggctgat
      841 tttggactgg tgcggccact gggcggcgcc cgaggtcgct acgttatggg tgggccccgt
      901 cccatcccct atgcctggtg cgctcctgag agcctacgcc agggagcctt ctcggctgcc
      961 tccgacgtgt ggatgtttgg cgtgacactc tgggaaatgt tttctggagg cgaggaaccc
     1021 tgggcaggtg ttccaccata tctcatccta cagcggctgg agaaggaccg agccaggctg
     1081 ccaaagcctg ccctctgttc cagggccctc tactcccttg ccttgcgttg ctgggcccct
     1141 catcctgcag accggcctac cttttccaat ctggaaggac tgcttcaaga ggcttggctc
     1201 tctgaggggc gctgtgtgag ggaggtcaca gagccaggtg ctttgcggat ggagcccggt
     1261 gaccccatca ctatcattga gggcagccca gacaccacaa cctggaaggg acagaatggt
     1321 cgcaccctca aagtgggcaa ctttccggct tcagcagtga cactagcaga cttgggggga
     1381 tccccagtca cccatccagt ccacagaggt tcccctgccc gtggagagaa atacagaggg
     1441 ggcacagatg gggacaggga gaaggcagtg ttacaagacc tacccccggc acggaaccag
     1501 agaaggaagg tgcccctgca gaggatgaaa ggcatttcca agagtctgga gtcagttctg
     1561 tccctgggcc ctagacccgc aggaggtggt tcaagccctc cagaacttcg acgaggatgt
     1621 actagagctt ggcctcaagg actcgcagac ctccctccac gcccaccaga cctgcctcca
     1681 cgcccaccca tcatctgctc ctctcagccc atccagcccc acagagtccg gcccaaaaga
     1741 gaacccttac ataatcactg cactggagcg cctgggtcca gcaaagtcac tatcccccct
     1801 ggaggtccct tatcagactc ggagtggcag aggaagattg tagaggtaga gctgagtgtg
     1861 catggcgtca cctaccagga gtgccaaatg gcactcagaa ccatgggggg agatgtggct
     1921 tctgctatcc ggaacctcaa ggtagaccag ctcttccacc tcagtaaccg gtccagagca
     1981 gattgtcgtc gcattctgga gcatcaccac tgggacctgt cagcagccag tcgctacgtc
     2041 ctggcccggt cctga
//
LOCUS       NM_139335                927 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 126 (Tas2r126),
            mRNA.
ACCESSION   NM_139335
VERSION     NM_139335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   6  (bases 1 to 927)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   7  (bases 1 to 927)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF240768.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF240768.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..927
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="taste receptor, type 2, member 126"
                     /db_xref="GeneID:246219"
                     /db_xref="RGD:727853"
     CDS             1..927
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="T2R12; T2R41; taste receptor rT2R12"
                     /codon_start=1
                     /product="taste receptor type 2 member 41"
                     /protein_id="NP_647551.1"
                     /db_xref="GeneID:246219"
                     /db_xref="RGD:727853"
                     /translation="MLSTVSVFFMSIFVLLCFLGILANGFIVLMLSREWLWRGRLLPS
                     DMILLSLGTSRFCQQCVGLVNSFYYSLHLVEYSRSLARQLISLHMDFLNSATFWFGTW
                     LSVLFCIKIANFSHPAFLWLKWRFPALVPWLLLGSILVSFIVTLMFFWGNHTVYQAFL
                     RRKFSGNTTFKEWNRRLEIDYFMPLKLVTTSIPCSLFLVSILLLINSLRRHSQRMQHN
                     AHSLQDPNTQAHSRALKSLISFLVLYALSYVSMVIDATVVISSDNVWYWPWQIILYLC
                     MSVHPFILITNNLKFRGTFRQLLLLARGFWVT"
     misc_feature    19..888
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="mammalian taste receptor 2, subtype 41, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R41-like; cd15018"
                     /db_xref="CDD:320146"
     misc_feature    19..888
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="mammalian taste receptor 2, subtype 41, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R41-like; cd15018"
                     /db_xref="CDD:320146"
     misc_feature    19..81
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    22..99
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320146"
     misc_feature    22..99
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320146"
     misc_feature    133..207
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320146"
     misc_feature    133..207
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320146"
     misc_feature    181..243
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    247..315
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320146"
     misc_feature    247..315
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320146"
     misc_feature    271..333
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    394..444
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320146"
     misc_feature    394..444
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320146"
     misc_feature    454..456
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKE7.1); glycosylation site"
     misc_feature    499..501
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKE7.1); glycosylation site"
     misc_feature    535..606
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320146"
     misc_feature    535..606
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320146"
     misc_feature    553..615
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    679..756
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320146"
     misc_feature    679..756
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320146"
     misc_feature    718..780
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     misc_feature    787..864
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320146"
     misc_feature    787..864
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320146"
     misc_feature    793..855
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKE7.1);
                     transmembrane region"
     exon            1..927
                     /gene="Tas2r126"
                     /gene_synonym="Tas2r41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctatcaa ctgtatcagt tttcttcatg tcgatctttg ttctgctctg tttcctggga
       61 atcctggcaa acggcttcat tgtgctgatg ctgagcaggg aatggctatg gcgcggtagg
      121 ctgctcccct cagacatgat cctcctcagt ttgggcacct cccgattctg ccagcagtgc
      181 gttgggctgg tgaacagttt ctactattcc ctccaccttg ttgagtactc caggagcctt
      241 gcccgtcaac tcattagtct tcacatggac ttcttgaact cagccacttt ctggtttggc
      301 acctggctca gcgtcctgtt ctgtatcaag attgctaact tctcccatcc tgccttcctg
      361 tggttgaagt ggagattccc agcattggtg ccttggctcc tactgggctc tatcttggtg
      421 tccttcatcg taactctgat gttcttttgg ggaaaccaca ctgtctatca ggcattctta
      481 aggagaaagt tttctgggaa cacaaccttt aaggagtgga acagaaggct ggaaatagac
      541 tatttcatgc ctctgaaact tgtcaccacg tcaattcctt gctctctttt tctagtctca
      601 attttgctgt tgatcaattc tctcagaagg cattcacaaa gaatgcagca caatgctcac
      661 agcttgcaag accccaacac ccaggctcac agcagagccc tgaagtcact catctcattt
      721 ctggttcttt acgcgctgtc ctatgtgtcc atggtcattg acgctacagt tgtcatctcc
      781 tcagataacg tgtggtattg gccctggcaa attatacttt acttgtgcat gtccgtacat
      841 ccatttatcc ttatcactaa taatctcaag ttccgaggca ccttcaggca gctactcctg
      901 ttggccaggg gattctgggt gacctag
//
LOCUS       NM_001109596             936 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 125 (Tas2r125),
            mRNA.
ACCESSION   NM_001109596 NM_001085349 XM_001074563
VERSION     NM_001109596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before May 24, 2008 this sequence version replaced
            NM_001085349.1, XM_001074563.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..936
                     /gene="Tas2r125"
                     /note="taste receptor, type 2, member 125"
                     /db_xref="GeneID:690481"
                     /db_xref="RGD:1596030"
     exon            1..936
                     /gene="Tas2r125"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..936
                     /gene="Tas2r125"
                     /note="putative taste receptor T2R16; T2r125; taste
                     receptor type 2 member 16"
                     /codon_start=1
                     /product="taste receptor type 2 member 125"
                     /protein_id="NP_001103066.1"
                     /db_xref="GeneID:690481"
                     /db_xref="RGD:1596030"
                     /translation="MGIVIGIICAFIIIVQFIIGNVANGFIALVNIIDWVKRRKISLV
                     DQIITALAISRIDMLCSTFLIILITSLYPDLNTAVNMVKISNNIWIVANHFSIWLATS
                     LSIFYFLKIANFSNYVFLCLRWRLSKVVSVTLLLSLVLLLMNILIMNMHIDTWSDGFK
                     RNVSFGFRSKNCTLFFKLALLINTTFTCDPFTVSMVAFLLLIFSLWRHLKNMQYHAKG
                     SRDPSTAVHIKALQMVVVFVLFYTFFFLSLAIQLWTSESLEKNNLFYVTLIITFPSVH
                     SCMLILRNSKLRQASLLVLWWLLCRSKDIQTLVP"
     misc_feature    10..72
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    46..888
                     /gene="Tas2r125"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    46..888
                     /gene="Tas2r125"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    136..210
                     /gene="Tas2r125"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    136..210
                     /gene="Tas2r125"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    142..204
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    250..318
                     /gene="Tas2r125"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    250..318
                     /gene="Tas2r125"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    265..327
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    388..450
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    397..447
                     /gene="Tas2r125"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    397..447
                     /gene="Tas2r125"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    487..489
                     /gene="Tas2r125"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET4.1); glycosylation site"
     misc_feature    514..516
                     /gene="Tas2r125"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET4.1); glycosylation site"
     misc_feature    529..600
                     /gene="Tas2r125"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    529..600
                     /gene="Tas2r125"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    550..552
                     /gene="Tas2r125"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ET4.1); glycosylation site"
     misc_feature    559..621
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    673..750
                     /gene="Tas2r125"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    673..750
                     /gene="Tas2r125"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    700..762
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
     misc_feature    784..855
                     /gene="Tas2r125"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    784..855
                     /gene="Tas2r125"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    787..849
                     /gene="Tas2r125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ET4.1);
                     transmembrane region"
ORIGIN      
        1 acgatgggta ttgtcatagg gatcatatgt gcctttatta taattgtgca attcataatt
       61 gggaatgttg caaatggatt catagcactg gtgaacatca tagactgggt aaagagaaga
      121 aaaatctctt tagtggatca gatcattact gctttggcta tatccaggat agatatgctg
      181 tgctctacat tcttaattat actaataact tcattgtatc cagatctaaa tacggctgtg
      241 aacatggtaa aaataagcaa taatatctgg attgttgcca atcatttcag catctggctt
      301 gctacaagcc tcagcatctt ttatttcctc aagatagcta acttttctaa ctatgttttt
      361 ctctgcttaa ggtggagact tagcaaagtg gtttcagtga cattgctgct ctctctggtc
      421 ctcttgctta tgaatatttt aataatgaac atgcatattg atacctggag tgatggattc
      481 aaaagaaacg tctcttttgg cttcagatca aagaattgca ctctcttttt caaacttgct
      541 cttttaatca acacaacgtt cacgtgtgac cccttcactg tgtccatggt ggcgtttctg
      601 cttctcatct tctccctgtg gagacacctg aagaacatgc agtaccatgc taaaggctcc
      661 agagacccca gcactgccgt gcatataaag gccttacaaa tggtggtggt cttcgttctg
      721 ttctacacat ttttcttttt gtctcttgcc atacaacttt ggacgtccga gtctctagag
      781 aaaaacaatc tgttttatgt cactcttata attacttttc cttcagtcca ttcatgtatg
      841 ctgattctga gaaacagtaa actgaggcag gcatctcttt tggtgctgtg gtggctgctg
      901 tgcagatcca aagacataca gactttggtt ccctga
//
LOCUS       NM_153301               2062 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b),
            mRNA.
ACCESSION   NM_153301
VERSION     NM_153301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Wakabayashi,M., Yoshioka,T., Higashino,K., Numata,Y., Igarashi,Y.
            and Kihara,A.
  TITLE     Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model
            rats
  JOURNAL   J Dermatol Sci 85 (3), 186-196 (2017)
   PUBMED   28024685
  REMARK    GeneRIF: Consistent with the decreases in the 15-LOX metabolites,
            expression levels of the genes that encode the 15-LOXs, Alox15 and
            Alox15b, were largely reduced in Olmsted syndrome model rats.
REFERENCE   2  (bases 1 to 2062)
  AUTHORS   Bender,G., Schexnaydre,E.E., Murphy,R.C., Uhlson,C. and
            Newcomer,M.E.
  TITLE     Membrane-dependent Activities of Human 15-LOX-2 and Its Murine
            Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS
  JOURNAL   J Biol Chem 291 (37), 19413-19424 (2016)
   PUBMED   27435673
REFERENCE   3  (bases 1 to 2062)
  AUTHORS   Green,A.R., Barbour,S., Horn,T., Carlos,J., Raskatov,J.A. and
            Holman,T.R.
  TITLE     Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2
            Delineates Its Transcellular Synthesis Potential
  JOURNAL   Biochemistry 55 (20), 2832-2840 (2016)
   PUBMED   27145229
REFERENCE   4  (bases 1 to 2062)
  AUTHORS   Kobe,M.J., Neau,D.B., Mitchell,C.E., Bartlett,S.G. and
            Newcomer,M.E.
  TITLE     The structure of human 15-lipoxygenase-2 with a substrate mimic
  JOURNAL   J Biol Chem 289 (12), 8562-8569 (2014)
   PUBMED   24497644
REFERENCE   5  (bases 1 to 2062)
  AUTHORS   Shen,T., Ma,J., Zhang,L., Yu,X., Liu,M., Hou,Y., Wang,Y., Ma,C.,
            Li,S. and Zhu,D.
  TITLE     Positive feedback-loop of telomerase reverse transcriptase and
            15-lipoxygenase-2 promotes pulmonary hypertension
  JOURNAL   PLoS One 8 (12), e83132 (2013)
   PUBMED   24376652
  REMARK    GeneRIF: Positive feedback-loop of TERT and 15-lipoxygenase-2
            promotes pulmonary hypertension.
            Erratum:[PLoS One. 2024 Aug 8;19(8):e0308871. doi:
            10.1371/journal.pone.0308871. PMID: 39116122]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2062)
  AUTHORS   Muga,S.J., Thuillier,P., Pavone,A., Rundhaug,J.E., Boeglin,W.E.,
            Jisaka,M., Brash,A.R. and Fischer,S.M.
  TITLE     8S-lipoxygenase products activate peroxisome proliferator-activated
            receptor alpha and induce differentiation in murine keratinocytes
  JOURNAL   Cell Growth Differ 11 (8), 447-454 (2000)
   PUBMED   10965849
REFERENCE   7  (bases 1 to 2062)
  AUTHORS   Jisaka,M., Kim,R.B., Boeglin,W.E. and Brash,A.R.
  TITLE     Identification of amino acid determinants of the positional
            specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
  JOURNAL   J Biol Chem 275 (2), 1287-1293 (2000)
   PUBMED   10625675
REFERENCE   8  (bases 1 to 2062)
  AUTHORS   Kilty,I., Logan,A. and Vickers,P.J.
  TITLE     Differential characteristics of human 15-lipoxygenase isozymes and
            a novel splice variant of 15S-lipoxygenase
  JOURNAL   Eur J Biochem 266 (1), 83-93 (1999)
   PUBMED   10542053
REFERENCE   9  (bases 1 to 2062)
  AUTHORS   Jisaka,M., Kim,R.B., Boeglin,W.E., Nanney,L.B. and Brash,A.R.
  TITLE     Molecular cloning and functional expression of a phorbol
            ester-inducible 8S-lipoxygenase from mouse skin
  JOURNAL   J Biol Chem 272 (39), 24410-24416 (1997)
   PUBMED   9305900
REFERENCE   10 (bases 1 to 2062)
  AUTHORS   Brash,A.R., Boeglin,W.E. and Chang,M.S.
  TITLE     Discovery of a second 15S-lipoxygenase in humans
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6148-6152 (1997)
   PUBMED   9177185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF415240.1.
            
            On May 4, 2007 this sequence version replaced NM_153301.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF415240.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMD00132270,
                                           SAMD00132302 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2062              AF415240.1         9-2070
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2062
                     /gene="Alox15b"
                     /note="arachidonate 15-lipoxygenase, type B"
                     /db_xref="GeneID:266604"
                     /db_xref="RGD:628809"
     exon            1..175
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="Alox15b"
                     /note="upstream in-frame stop codon"
     CDS             29..2062
                     /gene="Alox15b"
                     /EC_number="1.13.11.33"
                     /note="arachidonate 15-lipoxygenase type II; arachidonate
                     15-lipoxygenase B; 15-LOX-2; 15-LOX-B; 15-lipoxygenase 2;
                     arachidonate 15-lipoxygenase, second type; linoleate
                     13-lipoxygenase 15-LOb"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15B"
                     /protein_id="NP_695213.1"
                     /db_xref="GeneID:266604"
                     /db_xref="RGD:628809"
                     /translation="MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKE
                     FSAGAEEDFEVTLPQDVGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAA
                     LRFPCYQWLEGAGELVLREGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWP
                     HCLDHETVKDLDLNIKYSAMKNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMF
                     NFHNTPAAEYVFAHWQEDAFFASQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPG
                     TSLQAELEKGSLFLVDHGILSGVQTNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQL
                     KQTPGPDNPIFLPSDDKWDWLLAKTWVRNAEFSIHEALTHLLHAHLIPEVFALATLRQ
                     LPHCHPLFKLLIPHTRYTLHINTLARELLIAPGKVVDKSTGLGIGGFSDLIKRNMEQL
                     SYSVLCLPEDIRARDVGDLPGYYYRDDGMQIWSAIRSFVSEIVDIYYPSDASVRDDQE
                     LQAWVGEIFSEGFLSQESSGMPSLLDTQEALVQYVTMVIFTCSAKHAAVSASQFDSCV
                     WMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNATCDVIIALWLLSKEPGDRRPLGHY
                     PDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLALPYTYLDPPLIENSVSI"
     misc_feature    32..394
                     /gene="Alox15b"
                     /note="PLAT domain of 12/15-lipoxygenase. As a unique
                     subfamily of the mammalian lipoxygenases, they catalyze
                     enzymatic lipid peroxidation in complex biological
                     structures via direct dioxygenation of phospholipids and
                     cholesterol esters of biomembranes and...; Region:
                     PLAT_LOX; cd01753"
                     /db_xref="CDD:238851"
     misc_feature    32..394
                     /gene="Alox15b"
                     /note="PLAT domain of 12/15-lipoxygenase. As a unique
                     subfamily of the mammalian lipoxygenases, they catalyze
                     enzymatic lipid peroxidation in complex biological
                     structures via direct dioxygenation of phospholipids and
                     cholesterol esters of biomembranes and...; Region:
                     PLAT_LOX; cd01753"
                     /db_xref="CDD:238851"
     misc_feature    <725..2032
                     /gene="Alox15b"
                     /note="Region: Lipoxygenase; pfam00305"
                     /db_xref="CDD:459754"
     misc_feature    <725..2032
                     /gene="Alox15b"
                     /note="Region: Lipoxygenase; pfam00305"
                     /db_xref="CDD:459754"
     exon            176..398
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            399..480
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            481..603
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            604..707
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            708..880
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1027
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1231
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1318
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1488
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1610
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1711
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1882
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2062
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtagaga gccagactgg tcaggaggat ggctaaattc agggtgagag tatccaccgg
       61 ggaggcctgt ggggcaggca catgggacaa agtgtctgtc agcatcgtgg gaacccatgg
      121 agagagcccc ttagtacctc tggaccatct gggcaaggag ttcagcgctg gagctgaaga
      181 agacttcgag gtgacgcttc cccaggacgt tggcactgtg ctgatgctgc gaatacacaa
      241 ggcacccccg gaggcacccc tcccacttct gtctttccca cctgatgcct ggtactgccg
      301 ctggtttgag ctggagtggc tgccgggggc tgcacttcgc ttcccctgtt atcagtggct
      361 ggaaggggca ggggagctgg tgctgagaga gggagcagcc aaggtgtcct ggcaagacca
      421 ccaccgtacg ctgcaggatc agcgccagaa ggagctggag tccaggaagg acatgtacag
      481 ctggaagact tacattgaag gttggcctca ctgccttgac catgagaccg tgaaagactt
      541 ggacctcaac atcaagtact ctgcaatgaa gaacgccaaa ttcttcttta aagcccagtc
      601 tgcgtttaca gagctgaaat tcaaagggct cctggaccgc acaggactct ggaggagtct
      661 gagggagatg aaaaggatgt ttaacttcca caacactcca gcagcagagt atgtgtttgc
      721 acactggcag gaagatgcct tcttcgcctc ccagttccta aatggcctca acccagttct
      781 gattcgccgc tgtcgcagac tcccagagaa cttcccagtc actgatgaaa tggtggctcc
      841 agtgctgggc cctgggacca gtctgcaggc tgagttagag aagggctccc tgttcttggt
      901 ggaccatgga attctttctg gagtgcaaac caatgtcatc aatggaaagc ctcagttctc
      961 agcagccccg atgaccctat tataccagag tccagggtcc ggacccctgc ttcccatcgc
     1021 catacagctc aaacagactc ccgggccaga caaccccatc ttcctgccca gcgatgacaa
     1081 gtgggactgg ctactggcca agacctgggt gcgcaacgct gagttttcca tccacgaggc
     1141 tctcacgcat ctgctgcatg cccacctgat tccagaagtc tttgccttgg ccacactgcg
     1201 ccagctgccc cactgtcacc ctctcttcaa gctgctgatt cctcacactc ggtacacact
     1261 gcacatcaac acactcgccc gtgagctgct cattgcccct gggaaggtgg tggacaagtc
     1321 cacaggcctt ggcattgggg gattctctga cctgataaag agaaacatgg agcagctgag
     1381 ctattctgtc ctgtgtctcc ctgaagatat ccgagcccga gatgtgggag acctcccagg
     1441 atactattac cgagatgatg ggatgcagat ctggagtgca ataaggagct tcgtctctga
     1501 gatagttgac atctattacc caagtgacgc atctgtccga gatgaccaag agctccaggc
     1561 ctgggtgggg gagatcttct ctgagggctt cctcagccaa gaaagctcag gtatgccctc
     1621 cttgttggat acccaggaag ccctggtcca atatgttacc atggtgatat tcacctgctc
     1681 agccaagcat gcagctgtca gtgcaagcca gtttgactcg tgtgtttgga tgcccaatct
     1741 gccaccttcc atgcagctac caccacctac ttccaaaggc caggcaagcc ctgagggttt
     1801 catagccaca ctcccagcag tcaatgccac atgtgatgtc atcatcgccc tctggctgct
     1861 aagcaaggag ccaggggacc gtaggcccct gggccactat ccagatgagc acttcacaga
     1921 ggaggtccca cggcggagca tcgcggcctt ccagagaaag ctgatccaga tatccagtgg
     1981 catcaggaag aggaaccaaa gcctggcact gccctacacc tacctggatc ctcccctcat
     2041 cgagaacagt gtctccatct aa
//
LOCUS       NM_017337               3426 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus phosphodiesterase 3A (Pde3a), mRNA.
ACCESSION   NM_017337 XM_001073892
VERSION     NM_017337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Skryabin,E.B., De Jong,K.A., Subramanian,H., Bork,N.I., Froese,A.,
            Skryabin,B.V. and Nikolaev,V.O.
  TITLE     CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes
            Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and
            PDE3A Isoforms
  JOURNAL   Cells 12 (11), 1543 (2023)
   PUBMED   37296663
  REMARK    GeneRIF: CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult
            Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various
            PDE2A and PDE3A Isoforms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Ercu,M., Mucke,M.B., Pallien,T., Marko,L., Sholokh,A.,
            Schachterle,C., Aydin,A., Kidd,A., Walter,S., Esmati,Y.,
            McMurray,B.J., Lato,D.F., Yumi Sunaga-Franze,D., Dierks,P.H.,
            Flores,B.I.M., Walker-Gray,R., Gong,M., Merticariu,C., Zuhlke,K.,
            Russwurm,M., Liu,T., Batolomaeus,T.U.P., Pautz,S., Schelenz,S.,
            Taube,M., Napieczynska,H., Heuser,A., Eichhorst,J., Lehmann,M.,
            Miller,D.C., Diecke,S., Qadri,F., Popova,E., Langanki,R.,
            Movsesian,M.A., Herberg,F.W., Forslund,S.K., Muller,D.N.,
            Borodina,T., Maass,P.G., Bahring,S., Hubner,N., Bader,M. and
            Klussmann,E.
  TITLE     Mutant Phosphodiesterase 3A Protects From Hypertension-Induced
            Cardiac Damage
  JOURNAL   Circulation 146 (23), 1758-1778 (2022)
   PUBMED   36259389
  REMARK    GeneRIF: Mutant Phosphodiesterase 3A Protects From
            Hypertension-Induced Cardiac Damage.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Ercu,M., Marko,L., Schachterle,C., Tsvetkov,D., Cui,Y.,
            Maghsodi,S., Bartolomaeus,T.U.P., Maass,P.G., Zuhlke,K.,
            Gregersen,N., Hubner,N., Hodge,R., Muhl,A., Pohl,B., Illas,R.M.,
            Geelhaar,A., Walter,S., Napieczynska,H., Schelenz,S., Taube,M.,
            Heuser,A., Anistan,Y.M., Qadri,F., Todiras,M., Plehm,R., Popova,E.,
            Langanki,R., Eichhorst,J., Lehmann,M., Wiesner,B., Russwurm,M.,
            Forslund,S.K., Kamer,I., Muller,D.N., Gollasch,M., Aydin,A.,
            Bahring,S., Bader,M., Luft,F.C. and Klussmann,E.
  TITLE     Phosphodiesterase 3A and Arterial Hypertension
  JOURNAL   Circulation 142 (2), 133-149 (2020)
   PUBMED   32524868
  REMARK    GeneRIF: Phosphodiesterase 3A and Arterial Hypertension.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Gershon,E., Maimon,I., Galiani,D., Elbaz,M., Karasenti,S. and
            Dekel,N.
  TITLE     High cGMP and low PDE3A activity are associated with oocyte meiotic
            incompetence
  JOURNAL   Cell Cycle 18 (20), 2629-2640 (2019)
   PUBMED   31401933
  REMARK    GeneRIF: High cGMP and low PDE3A activity are associated with
            oocyte meiotic incompetence.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Berrisch,S., Ostermeyer,J., Kaever,V., Kalble,S.,
            Hilfiker-Kleiner,D., Seifert,R. and Schneider,E.H.
  TITLE     cUMP hydrolysis by PDE3A
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (3), 269-280 (2017)
   PUBMED   27975297
  REMARK    GeneRIF: PDE3A is a low-affinity and high-velocity enzyme for
            hydrolysis of cUMP in cardiac myocytes.
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Richard,F.J., Tsafriri,A. and Conti,M.
  TITLE     Role of phosphodiesterase type 3A in rat oocyte maturation
  JOURNAL   Biol Reprod 65 (5), 1444-1451 (2001)
   PUBMED   11673261
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Shitsukawa,K., Andersen,C.B., Richard,F.J., Horner,A.K.,
            Wiersma,A., van Duin,M. and Conti,M.
  TITLE     Cloning and characterization of the cyclic guanosine
            monophosphate-inhibited phosphodiesterase PDE3A expressed in mouse
            oocyte
  JOURNAL   Biol Reprod 65 (1), 188-196 (2001)
   PUBMED   11420239
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Liu,H. and Maurice,D.H.
  TITLE     Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B
            (PDE3A and PDE3B) in rat tissues: differential subcellular
            localization and regulated expression by cyclic AMP
  JOURNAL   Br J Pharmacol 125 (7), 1501-1510 (1998)
   PUBMED   9884079
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Nagaoka,T., Shirakawa,T., Balon,T.W., Russell,J.C. and
            Fujita-Yamaguchi,Y.
  TITLE     Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence
            for tissue-specific expression of phosphodiesterase 3A or 3B mRNA
            and activity in the aorta and adipose tissue of
            atherosclerosis-prone insulin-resistant rats
  JOURNAL   Diabetes 47 (7), 1135-1144 (1998)
   PUBMED   9648839
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   He,R., Komas,N., Ekholm,D., Murata,T., Taira,M., Hockman,S.,
            Degerman,E. and Manganiello,V.C.
  TITLE     Expression and characterization of deletion recombinants of two
            cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3)
  JOURNAL   Cell Biochem Biophys 29 (1-2), 89-111 (1998)
   PUBMED   9631240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U38179.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001073892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="phosphodiesterase 3A"
                     /db_xref="GeneID:50678"
                     /db_xref="RGD:61942"
     CDS             1..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /EC_number="3.1.4.17"
                     /note="cGMP-inhibited 3',5'-cyclic phosphodiesterase A;
                     CGI-PDE A; cyclic GMP-inhibited phosphodiesterase A;
                     cyclic nucleotide phosphodiesterase; phosphodiesterase 3A,
                     cGMP inhibited"
                     /codon_start=1
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase
                     3A"
                     /protein_id="NP_059033.1"
                     /db_xref="GeneID:50678"
                     /db_xref="RGD:61942"
                     /translation="MAVRGEAAQDWAKPGLRGPSPAPVARGDHRCRGGSPSSPRGSGC
                     CWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEEEEEE
                     GARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVAL
                     LAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSAL
                     RTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSAR
                     TKEEIPGWKRRRRSSSVVAGEMSGCGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGS
                     QSGTSVTVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRV
                     NPTVTFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTL
                     EPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAK
                     KQNRPGGLDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALT
                     YTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADGPSERSGPAMQKPNRTDDTSQVTSD
                     YETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMDNL
                     DSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFH
                     ALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGH
                     MGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQA
                     VLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHF
                     DFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEF
                     YEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDS
                     DDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKK
                     VIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPDL"
     misc_feature    1..123
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    184..246
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    265..333
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    379..441
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    469..531
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    544..606
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    619..681
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    685..747
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     transmembrane region"
     misc_feature    784..927
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    928..930
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14432; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    1297..1437
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1474..1476
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14432; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    1510..1929
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1558..1560
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14432; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    1570..1572
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0X4; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    1597..1599
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0X4; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    2005..3423
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Interaction with SLFN12.
                     /evidence=ECO:0000250|UniProtKB:Q14432"
     misc_feature    2251..3036
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
     misc_feature    2251..3036
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="3'5'-cyclic nucleotide phosphodiesterase; Region:
                     PDEase_I; pfam00233"
                     /db_xref="CDD:459723"
     misc_feature    3070..3186
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3097..3099
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0X4; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    3106..3108
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0X4; propagated from
                     UniProtKB/Swiss-Prot (Q62865.1); phosphorylation site"
     misc_feature    3292..3423
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62865.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..954
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1005
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1260
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1415
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1540
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1760
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1846
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2001
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2139
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2251
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2365
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2565
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2769
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2925
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3184
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3426
                     /gene="Pde3a"
                     /gene_synonym="RNPDE3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagtgc ggggcgaggc cgcccaagac tgggccaagc ccggtctccg agggccgagt
       61 cctgccccgg tggccagagg ggaccaccgc tgtcgtggcg ggtccccttc atcccctcgg
      121 ggctcgggct gttgttggcg agccctggcg ttgcagcctc tccggcgctc gccgcaactc
      181 tcctccgcgt tgtgcgcggg ctccctgtcc gtgctgctgg cgctgctggt gaggctggtc
      241 ggcggggagg tcggaggcga gctggagtcg agtcaggagg cggcggccga ggaggaggag
      301 gaggaaggag cccgaggggg cgtcttcccg ggccctcggg gaggtgctcc cgggggcggc
      361 gcgcagctca gcccttggct gcagccggcc gcgctgctct tcagtctcct gtgcgccttc
      421 ttctggatgg gcttgtgcct gctgcgcgcc ggggtgcgcc tgcctctggc cgtcgcgctg
      481 ttggccgcct gctgcgccgg ggaagcgctg gtgcagctct ccttgggcgt gggggacggt
      541 cgcctgctgt cgctacccgc cgcgggggtc ctgctcagct gcctaggtgg cgcgacatgg
      601 ctggtgctga ggctgaggct gggcgtcctc atggtcgctt tgactagcgc cctcaggacg
      661 gtggccctgg tttctctgga gaggttcaag gtcgcctgga gaccttacct ggcatacttg
      721 gcggccgtgc ttgggctgct gctggccagg tacgccgagc agctcctgcc gcagtgctcc
      781 gggccggctc cgcccaggga gcggtttggg tcccagtcga gcgcgaggac caaggaagag
      841 attccggggt ggaagaggag gaggcggtcc agctcggtgg tggccggcga gatgtccggc
      901 tgcggtggca agtctcaccg gaggacctcc ctgccctgca tacccaggga gcagctcatg
      961 ggccattcag aatgggacca caagagaggg tcacgaggat cccagtcagg aaccagcgtc
     1021 accgtggata ttgccgtgat gggcgaggcg catggcctca ttaccgacct cctggccgac
     1081 ccttctttgc ctccgaatgt gtgcacgtcc ttgagggccg tgagcaacct gctcagtacc
     1141 cagctcacct tccaggcaat ccacaagccc agagtgaacc ccactgtgac cttcagtgag
     1201 aactatacct gctccgactc tgaggaaggc ttggagaaag acaagctggc cattcccaag
     1261 cgcctgagaa gaagtttgcc tccaggcttg ctgaggagag tttcatcaac ttggacaact
     1321 accacctctg ccacaggact gcctaccttg gagcctgcgc cagtgcggag ggaccgcagc
     1381 gccagcataa agccacatga agccccttca cccagtgctg tcaaccctga ctcttggaat
     1441 gccccagtgt tgatgactct aaccaaaagc aggtccttca cttcgtccta tgctgtctct
     1501 gcagctaacc acgtcaaagc taaaaagcaa aacaggccag gtggccttga taagatttcg
     1561 cccgttccct cgccctcctc ctcacctcct caaggatcac ccaccagcag tcctgtcagt
     1621 ggcattgctt ccgtacagtt cccggaatcc cctgaagtca ccaccaaacg aggccctgga
     1681 tctcacaggg ccttaactta cacccagagt gcccctgacc tgtcccccca gatcccgccc
     1741 tcacctgtca tatgtagcag ctgtggcaga ccttactcac aagggaatcc tgctgatgga
     1801 ccttcagaga gaagtggccc agccatgcag aaaccaaaca gaacagatga tacttctcaa
     1861 gttacctctg attatgagac caacaacaac agtgacagca gcgacatcct gcagaatgat
     1921 gaggaagccg agtgccagag agagccactg aggaaagcat cggcttgtgg cacctatact
     1981 ccccagacca tgatcttcct ggacaaacca attcttgctc cagaacccct ggtcatggat
     2041 aacctggatt caattatgga tcagttgaac acctggaatt ttccaatttt tgatttagtg
     2101 gaaaacatag gaagaaaatg tggccgtatt ctgagccagg tgtcatacag actctttgaa
     2161 gacatggggc tctttgaagc ctttaaaatc ccggttaggg agtttatgaa ttactttcat
     2221 gctttggaga tcggctacag ggacattcct tatcataaca gaatccacgc cactgatgtt
     2281 ttgcacgccg tgtggtatct cacaacacag ccgattcctg gcctcccgag tgtgattggt
     2341 gatcacggct cggcaagtga ctctgattct gacagtgggt ttacacacgg acacatggga
     2401 tatgtgtttt ccaaagcgta tcatgtgcca gatgacaaat atggatgcct gtctggaaat
     2461 attccagccc tggagttgat ggccctgtat gttgctgcag ccatgcatga ctacgatcac
     2521 ccaggaagga caaatgcttt cctggttgcc actagcgccc ctcaggccgt gctgtacaat
     2581 gaccgttccg ttctggagaa ccatcacgca gctgcagcct ggaatctctt catgtcccgg
     2641 ccggagtata acttcttagt taacctggac catgtggaat ttaagcactt ccgattccta
     2701 gtcattgaag caattctggc tactgacctg aagaaacact ttgactttgt agccaagttt
     2761 aatgccaagg tgaatgatga tgttgggata gattggacca atgaaaacga ccgtctcctg
     2821 gtgtgtcaga tgtgtataaa gttggctgac atcaacgggc ctgctaaatg taaggacctc
     2881 cacctgcggt ggacggaggg catcgccagc gagttttatg agcagggcga tgaagaagcc
     2941 agccttggtt tgcccataag cccatttatg gaccgctctg ccccgcagct ggccaatctt
     3001 caggagtcct ttatctcaca catcgtgggt cctctttgcc actcctacga ctctgcgggt
     3061 ctcatgccgg gaaaatgggt agatgacagt gatgattcag gagacactga tgacccggaa
     3121 gaagaggagg aagaggctga aacaccacac gaggaagaaa cctgtgaaaa cagtgaagct
     3181 cccagaaaga aaagtttcaa aagaaggaga atctactgtc aaataactca gcaccttctg
     3241 cagaaccaca tgatgtggaa gaaagtgatt gaagaggagc agtgtttatc aggcacagag
     3301 aaccaggccc cagaccaggc accgctgcag cattcctcag aacaaatcca ggctatcaag
     3361 gaggaggagg aagagaaggg gaagccaaga gcagaggaaa ccctcgctcc acaaccagac
     3421 ctgtga
//
LOCUS       NM_001004129             312 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus stefin A2-like 1 (Stfa2l1), mRNA.
ACCESSION   NM_001004129 XM_579128
VERSION     NM_001004129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 312)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000376.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579128.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..312
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /note="stefin A2-like 1"
                     /db_xref="GeneID:408214"
                     /db_xref="RGD:1303106"
     CDS             1..312
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /function="cysteine protease inhibitor"
                     /note="stefin A2"
                     /codon_start=1
                     /product="stefin-3"
                     /protein_id="NP_001004129.1"
                     /db_xref="GeneID:408214"
                     /db_xref="RGD:1303106"
                     /translation="MNQDTIVITGGLSEARPATPEIQEIADKVKTLLEEKTNGKYEKF
                     EAIQYKVQVVAGRNYFIKMDVGHGCFTHIKVFQGLSGKDDLELSGYQTNKTKNDELTH
                     F"
     misc_feature    28..291
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /note="Cystatin domain; Region: Cystatin; pfam00031"
                     /db_xref="CDD:425431"
     misc_feature    28..291
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /note="Cystatin domain; Region: Cystatin; pfam00031"
                     /db_xref="CDD:425431"
     misc_feature    order(28..30,154..162,166..168)
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     misc_feature    order(28..30,154..162,166..168)
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     exon            1..84
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..186
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..312
                     /gene="Stfa2l1"
                     /gene_synonym="Stfa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatcaag acaccatagt aataacagga ggcttgtcgg aggccagacc tgccacacca
       61 gaaatccagg agatcgctga caaggtcaaa actctgcttg aagagaaaac caatgggaaa
      121 tatgaaaaat tcgaagccat ccagtataaa gttcaagtcg tcgctggacg aaattacttc
      181 attaagatgg atgtggggca tggttgtttc acccacataa aagtcttcca gggtctttct
      241 ggaaaggatg atttggaact tagtggttac cagactaaca aaaccaagaa tgatgagctg
      301 acccacttct aa
//
LOCUS       NM_001080938             930 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 124 (Tas2r124),
            mRNA.
ACCESSION   NM_001080938 XM_001074538
VERSION     NM_001080938.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362745.1.
            
            On Jan 31, 2007 this sequence version replaced XM_001074538.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..930
                     /gene="Tas2r124"
                     /note="taste receptor, type 2, member 124"
                     /db_xref="GeneID:690472"
                     /db_xref="RGD:1596038"
     CDS             1..930
                     /gene="Tas2r124"
                     /note="putative taste receptor T2R25; T2R124; taste
                     receptor type 2 member 25"
                     /codon_start=1
                     /product="taste receptor type 2 member 124"
                     /protein_id="NP_001074407.1"
                     /db_xref="GeneID:690472"
                     /db_xref="RGD:1596038"
                     /translation="MVSVLHSISTIIIIAEFVWGNLSNGLIVLKNCLDWINIKELSTL
                     DQILILLAISRISLIWETLLMWVKDKLISSITIEELKMIMFSFMLSSHFSLWLATALS
                     TFYLFRIANCSWQIFLYLKWRLKHLIVQMLLGSVMFLIANIIQITITLEKRFYQYKGN
                     TSVNSIQNEFALLIEMMLFNMTIFSVIPFLLALISFFLLIFSLWKHLQRMQLNSREDR
                     DPSTKAHRNALGIMVSFLLLYTMYVLSLLISWIAQKNQSELVHIICMITSLLNPSVHS
                     SILILGNFKLKQSSLCILRHLGCRLKSQNTPTT"
     misc_feature    19..873
                     /gene="Tas2r124"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    19..873
                     /gene="Tas2r124"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..84
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    25..99
                     /gene="Tas2r124"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    25..99
                     /gene="Tas2r124"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    133..198
                     /gene="Tas2r124"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    133..198
                     /gene="Tas2r124"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    139..201
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    241..309
                     /gene="Tas2r124"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    241..309
                     /gene="Tas2r124"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..306
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    382..444
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    388..438
                     /gene="Tas2r124"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    388..438
                     /gene="Tas2r124"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    478..480
                     /gene="Tas2r124"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES5.1); glycosylation site"
     misc_feature    520..591
                     /gene="Tas2r124"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    520..591
                     /gene="Tas2r124"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    538..540
                     /gene="Tas2r124"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES5.1); glycosylation site"
     misc_feature    547..609
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    673..741
                     /gene="Tas2r124"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    673..741
                     /gene="Tas2r124"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    682..744
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     misc_feature    763..765
                     /gene="Tas2r124"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ES5.1); glycosylation site"
     misc_feature    772..849
                     /gene="Tas2r124"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    772..849
                     /gene="Tas2r124"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    784..846
                     /gene="Tas2r124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ES5.1);
                     transmembrane region"
     exon            1..930
                     /gene="Tas2r124"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtatctg tcctgcacag catctccacc attataataa tcgcagagtt cgtttgggga
       61 aatttaagca atggtttgat agtactgaag aactgtcttg attggatcaa tataaaagag
      121 ctctccacac ttgatcagat actcattctc ttggcaattt ccagaattag tctcatctgg
      181 gagacattac tcatgtgggt taaagataaa ctaatttcat ctattaccat cgaagaattg
      241 aaaatgatta tgttcagttt tatgctatct agccacttca gtctctggct tgctacagct
      301 ctaagcacct tctatttatt cagaatagct aactgctctt ggcagatctt tctctactta
      361 aaatggagac taaaacatct gatcgtgcag atgctactgg gaagcgtgat gttcttgatt
      421 gcaaatataa tacaaataac catcactctt gaaaagaggt tctatcaata taaaggaaac
      481 acaagtgtga attccataca gaatgagttt gcacttttga tagagatgat gttatttaac
      541 atgactatat tttctgtgat accattttta ttggccctga tttctttttt tctgctaatc
      601 ttctctttat ggaaacatct ccagaggatg cagctcaatt ccagagaaga tagagaccct
      661 agtaccaagg ctcacaggaa tgccttagga attatggtct ctttcctctt gctctatact
      721 atgtatgtcc tctctcttct tatatcctgg attgctcaga agaatcaaag tgaactggtt
      781 cacattattt gtatgataac ttcactcttg aatccttcag tccactcatc tatcctgatt
      841 ctgggtaatt ttaaattaaa acagagttct ctttgtatac tgaggcacct gggatgtagg
      901 ctgaaatcac agaatacacc aactacataa
//
LOCUS       NM_001047113            1386 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ribonuclease/angiogenin inhibitor (LOC641544),
            mRNA.
ACCESSION   NM_001047113
VERSION     NM_001047113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1386)
  AUTHORS   Zhao,C.F., Liu,Y., Que,H.P., Yang,S.G., Liu,Z.Q., Weng,X.C.,
            Hui,H.D. and Liu,S.J.
  TITLE     SCIRR39 promotes differentiation of oligodendrocyte precursor cells
            and regulates expression of myelin-associated inhibitory factors
  JOURNAL   J Mol Neurosci 50 (3), 533-541 (2013)
   PUBMED   23440710
  REMARK    GeneRIF: The results indicate the important role of SCIRR39 either
            in oligodendrocyte precursor cell differentiation or in axon
            myelination.
REFERENCE   2  (bases 1 to 1386)
  AUTHORS   Zhao,C.F., Liu,Y., Ni,Y.L., Yang,J.W., Hui,H.D., Sun,Z.B. and
            Liu,S.J.
  TITLE     SCIRR39 promotes neurite extension via RhoA in NGF-induced PC12
            cells
  JOURNAL   Dev Neurosci 35 (5), 373-383 (2013)
   PUBMED   24021527
  REMARK    GeneRIF: Our results indicated that SCIRR39 increased the neurite
            extension in NGF-treated PC12 cells via RhoA, suggesting that
            SCIRR39 contributes to the regeneration of neuron injury by
            specifically altering the differentiation program.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY240937.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY240937.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
     gene            1..1386
                     /gene="LOC641544"
                     /note="ribonuclease/angiogenin inhibitor"
                     /db_xref="GeneID:641544"
                     /db_xref="RGD:1590758"
     CDS             1..1386
                     /gene="LOC641544"
                     /note="ribonuclease inhibitor"
                     /codon_start=1
                     /product="ribonuclease/angiogenin inhibitor"
                     /protein_id="NP_001040578.1"
                     /db_xref="GeneID:641544"
                     /db_xref="RGD:1590758"
                     /translation="MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEAR
                     CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGC
                     GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE
                     PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRD
                     LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL
                     CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFS
                     SVLAQNRFLLELQISNNRLEDAGVAELCQGPGQPGSVLRVLWLADCDVSDSSCSSLAA
                     TLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQAL
                     EKDKPSLRVIS"
     misc_feature    16..975
                     /gene="LOC641544"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    16..975
                     /gene="LOC641544"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    16..87
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    16..87
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(22..24,28..30,37..39,43..45,88..90,97..99,103..105,
                     112..114,118..120,172..174,181..183,187..189,196..198,
                     202..204,259..261,268..270,274..276,283..285,289..291,
                     343..345,352..354,358..360,367..369,373..375,430..432,
                     439..441,445..447,454..456,460..462,514..516,523..525,
                     529..531,538..540,544..546,601..603,610..612,616..618,
                     625..627,631..633,685..687,694..696,700..702,709..711,
                     715..717,772..774,781..783,787..789,796..798,802..804,
                     856..858,865..867,871..873,880..882,886..888,943..945,
                     952..954,958..960,967..969,973..975)
                     /gene="LOC641544"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    order(22..24,28..30,37..39,43..45,88..90,97..99,103..105,
                     112..114,118..120,172..174,181..183,187..189,196..198,
                     202..204,259..261,268..270,274..276,283..285,289..291,
                     343..345,352..354,358..360,367..369,373..375,430..432,
                     439..441,445..447,454..456,460..462,514..516,523..525,
                     529..531,538..540,544..546,601..603,610..612,616..618,
                     625..627,631..633,685..687,694..696,700..702,709..711,
                     715..717,772..774,781..783,787..789,796..798,802..804,
                     856..858,865..867,871..873,880..882,886..888,943..945,
                     952..954,958..960,967..969,973..975)
                     /gene="LOC641544"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    88..171
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    88..171
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(106..111,280..282,451..453,535..537,706..708,
                     784..786,790..792,868..870,955..957)
                     /gene="LOC641544"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    order(106..111,280..282,451..453,535..537,706..708,
                     784..786,790..792,868..870,955..957)
                     /gene="LOC641544"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    172..258
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    172..258
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    259..342
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    259..342
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    343..429
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    343..429
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    430..513
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    430..513
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    514..600
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    514..600
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    601..684
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    601..684
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <682..1290
                     /gene="LOC641544"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; Region: RNA1; COG5238"
                     /db_xref="CDD:444072"
     misc_feature    <682..1290
                     /gene="LOC641544"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; Region: RNA1; COG5238"
                     /db_xref="CDD:444072"
     misc_feature    685..771
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    685..771
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    772..834
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    772..834
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    856..942
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    856..942
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    943..1014
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    943..1014
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1027..1101
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1027..1101
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1114..1197
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1114..1197
                     /gene="LOC641544"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 atgtctctgg acatccagtc tctggacatc cagtgcgaag aactgtctga cgctcgttgg
       61 gctgaactgc tgccactgct gcagcagtgc caggtagtac gtctggacga ctgcggtctg
      121 acagaagctc gttgcaaaga catctcttct gctctgcgtg taaacccagc tctggctgaa
      181 ctgaacctgc gttctaacga actgggtgac gtaggtgtac attgcgtact gcagggtctg
      241 cagacaccat cttgcaaaat ccagaaactg tctctgcaga actgctgcct gacaggtgct
      301 ggttgcggtg tactgtcttc tacactgcgt acactgccaa cactgcagga actgcatctg
      361 tctgacaacc tgctgggtga cgctggtctg cagctgctgt gcgaaggtct gctggaccca
      421 cagtgccgtc tggaaaaact gcagctggaa tactgctctc tgtctgctgc ttcttgcgaa
      481 ccactggctt ctgtactgcg tgctaaacca gacttcaaag aactgacagt atctaacaac
      541 gacatcaacg aagctggtgt acgtgtactg tgccagggtc tgaaagactc tccatgccag
      601 ctggaagctc tgaaactgga atcttgcggt gtaacatctg acaactgccg tgacctgtgc
      661 ggtatcgtag cttctaaagc ttctctgcgt gaactggctc tgggttctaa caaactgggt
      721 gacgtaggta tggctgaact gtgcccaggt ctgctgcatc catcttctcg tctgcgtaca
      781 ctgtggatct gggaatgcgg tatcacagct aaaggttgcg gtgacctgtg ccgtgtactg
      841 cgtgctaaag aatctctgaa agaactgtct ctggctggta acgaactggg tgacgaaggt
      901 gctcgtctgc tgtgcgaaac actgctggaa ccaggttgcc agctggaatc tctgtgggta
      961 aaatcttgct ctttcacagc tgcttgctgc tctcatttct cttctgtact ggctcagaac
     1021 cgtttcctgc tggaactgca gatctctaac aaccgtctgg aagacgctgg tgtagctgaa
     1081 ctgtgccagg gtccaggtca gcctggctct gtgctgcggg tgctctggtt ggccgactgc
     1141 gatgtgtctg actcttcttg cagcagcctc gccgcgaccc tgttggccaa ccactctctg
     1201 cgtgagctgg acctctctaa caactgcctg ggtgacgctg gtatcctgca gctggtggaa
     1261 tctgtacgtc agccgggttg cctcctggaa cagctggtac tgtacgacat ttactggtct
     1321 gaagaaatgg aggaccgtct gcaggctctg gaaaaggaca agccatccct gagggtcatc
     1381 tcctga
//
LOCUS       NM_001002284            1062 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus MAS-related G protein-coupled receptor, member B5
            (Mrgprb5), mRNA.
ACCESSION   NM_001002284 XM_579074
VERSION     NM_001002284.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF518243.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579074.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1062
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="MAS-related G protein-coupled receptor, member B5"
                     /db_xref="GeneID:404644"
                     /db_xref="RGD:738052"
     CDS             1..1062
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="MAS-related gene B5"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B5"
                     /protein_id="NP_001002284.1"
                     /db_xref="GeneID:404644"
                     /db_xref="RGD:738052"
                     /translation="MPDSPTESYGPDREYHVFISLFLCRNTSGKFLSVGPATPGWSIN
                     NTVVKENYYTEKLSCIITFNTLNFLTATISVVGTAGNATVLRLLGFHMHRYAFSVYVF
                     NLAGADFLYLCTQTVYSLECVLQFDNSYFYFLLTILMFAYLAALCMIPAISTERCLSV
                     TWPIWYHCQRPRHTSATVCALFWAFSLLLRLLLGQGCGFLFGKYDYYFCRYCSFITTA
                     FLIVLFVVPFVSSLAMLTKIICGSHRIPVTRFYVTIAVTVLVFTFFGLPVGIISLLLP
                     RIVVFRGVFYIYKIVTFLYSVNCCANPIIYFLIGSIRHHRLQRQSLKLLLQRAMQDTP
                     EEEGGVKGPSQKSNELEIV"
     misc_feature    76..78
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN44.1); glycosylation site"
     misc_feature    130..132
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TN44.1); glycosylation site"
     misc_feature    190..1002
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    190..1002
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    193..273
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    193..273
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    202..270
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    289..369
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    289..369
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    289..351
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    order(352..354,361..366,397..414,418..423,430..432,
                     559..561,565..579,646..648,655..663,667..675,679..684,
                     793..795,802..807,811..816,823..825,859..867,874..876,
                     883..888)
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    order(352..354,361..366,397..414,418..423,430..432,
                     559..561,565..579,646..648,655..663,667..675,679..684,
                     793..795,802..807,811..816,823..825,859..867,874..876,
                     883..888)
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    394..456
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    397..483
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    397..483
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    517..579
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    517..579
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    541..603
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    640..702
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    646..723
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    646..723
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    733..825
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    733..825
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    760..822
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    856..930
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    856..930
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    868..930
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     transmembrane region"
     misc_feature    997..1059
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TN44.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1..1062
                     /gene="Mrgprb5"
                     /gene_synonym="MrgB5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccagaca gtcctacaga gtcatatggt cctgacagag agtatcatgt gttcatatct
       61 ctatttcttt gcaggaacac cagtggaaaa ttcctaagtg tgggtccagc caccccaggc
      121 tggagcatta acaacacagt agtgaaggaa aattactaca ctgaaaaatt atcctgtatc
      181 atcacgttca ataccctgaa ttttcttact gccaccattt ctgtggttgg gacggcagga
      241 aatgccacag tgctgcggct tctaggcttc cacatgcata ggtatgcctt ctccgtctat
      301 gtcttcaacc tggctggtgc tgatttcttg tacctttgca ctcagactgt gtactccctg
      361 gagtgtgtcc ttcagtttga taacagctac ttttattttc tcctcactat attaatgttt
      421 gcttaccttg cagctttgtg tatgattcca gccatcagta ctgagcgctg cctatctgtt
      481 acgtggccca tctggtatca ctgccaaaga ccaagacaca catcagccac tgtgtgtgca
      541 ctgttctggg ctttctctct actgttgagg cttctgttag ggcaaggctg tggcttcctg
      601 tttggtaagt atgattatta tttctgtagg tattgtagct ttatcactac tgcatttcta
      661 atagtattat ttgtggttcc ttttgtgtcc agcctggcca tgttgaccaa gatcatctgt
      721 ggatcacata ggattcctgt gaccagattc tatgtgacca ttgctgtcac agtgctggtc
      781 ttcacattct ttggtctgcc cgttgggatc atctcattac tcttacctcg gattgttgtg
      841 tttcgtggtg ttttttatat ttataaaata gtaacattcc tgtactctgt taactgctgt
      901 gccaatccca tcatttactt cctcattggc tccattaggc atcacaggtt acaaaggcag
      961 agtctgaagc tacttcttca gagagccatg caagacactc ctgaggaaga gggtggagtg
     1021 aagggtcctt cacaaaagtc taacgaactg gaaatagtct ga
//
LOCUS       NM_001008816            1359 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus keratin 42 (Krt42), mRNA.
ACCESSION   NM_001008816 XM_579213
VERSION     NM_001008816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004051.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579213.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004051.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840122,
                                           SAMN16418971 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1359
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="keratin 42"
                     /db_xref="GeneID:450231"
                     /db_xref="RGD:1359182"
     CDS             1..1359
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="K42; CK-42; cytokeratin-42; type I keratin KA22"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 42"
                     /protein_id="NP_001008816.1"
                     /db_xref="GeneID:450231"
                     /db_xref="RGD:1359182"
                     /translation="MASTTSIRQFSTSGSVKGLCAPGMGFSRMSSVRIGGACRAPSLL
                     GGGSCSNMSVTSSRFSAGLGGSYGGGYTCSLGGGFGSSFGVSDALLGGSEKETMQNLN
                     DRLATYLDRVRALEEANTDLEVKIREWYKKQGPGPARDYSPYFKTIEDLRNKILAATI
                     DNASIVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQI
                     ETLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEK
                     NRKDAEEWFFTKTEELNREVATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASL
                     ENSLAETEARYGAQLAQLQGLISSMEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIA
                     TYRRLLEGEDAHLATQYSSSLASQASREGTVTSRQVRTIVEEVQDGKVVSSREQVHRS
                     TH"
     misc_feature    10..279
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Head. /evidence=ECO:0000255"
     misc_feature    277..1212
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    277..1212
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    280..387
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Coil 1A. /evidence=ECO:0000255"
     misc_feature    388..441
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Linker 1. /evidence=ECO:0000255"
     misc_feature    442..717
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Coil 1B. /evidence=ECO:0000255"
     misc_feature    718..786
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Linker 12. /evidence=ECO:0000255"
     misc_feature    787..1203
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Coil 2. /evidence=ECO:0000255"
     misc_feature    1204..1356
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IFU7.1);
                     Region: Tail. /evidence=ECO:0000255"
     exon            1..462
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            463..545
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            546..702
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            703..864
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            865..990
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1211
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1261
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1359
                     /gene="Krt42"
                     /gene_synonym="Ka22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttcca ctaccagcat ccgccaattt tcaacctccg gctccgttaa gggcctttgc
       61 gctcctggca tggggttctc ccggatgtcc tccgtccgca ttgggggtgc ctgccgggct
      121 cccagtcttt tgggaggtgg cagctgtagc aatatgtcgg tcacctcctc ccgattctca
      181 gcgggcttag gaggcagcta cggtggtggc tacacttgca gcctgggagg gggctttggc
      241 tctagttttg gtgtgtcgga tgcccttctt gggggcagcg agaaggagac catgcagaac
      301 ctcaacgacc ggctggccac ctacttagac agggtgcgcg ccctggagga ggccaacact
      361 gacctggagg tgaagatccg tgagtggtat aagaagcagg gcccagggcc tgctcgtgat
      421 tacagcccct acttcaagac catagaggac ctgcggaaca agatcctggc agccacaatc
      481 gacaatgcca gcatcgtgct gcagatcgac aatgctcgcc tggcagccga tgacttccgc
      541 accaagtatg agacagagct gaatctgcgc atgagtgtgg aggcggacat caacggccta
      601 cgccgggtgc tggatgagct gaccctggcc agagctgacc tggagatgca gatcgagacc
      661 ctcaaggagg agttggccta cctgaagaag aaccatgagg aggagatgaa tgcccttcgt
      721 ggccaggtgg gcggggacgt caacgtggag atggatgcgg cccctggtgt ggacctgagc
      781 cgcatcctga acgagatgcg ggatcagtac gagaagatgg cagagaagaa ccgcaaggat
      841 gccgaggagt ggttcttcac caagacagag gagctgaacc gagaagtggc caccaacaca
      901 gaggccctgc agagcagccg gacggagatc acggagctcc gccgctctgt gcagaacttg
      961 gagattgagc tgcagtccca gctcagcatg aaagcatcgc tggagaacag cctggcagag
     1021 acagaggcac gttatggggc gcagctggcg cagctgcagg gcctcattag cagcatggag
     1081 cagcagctgt gtgagctgcg ttgtgacatg gaaaggcaga atcatgagta ccaggtgctg
     1141 ctggatgtga agaccaggct ggagcaggag atcgccactt accgccgcct gctggaggga
     1201 gaggatgccc acctggctac tcaatattcc tcatccctgg cttcgcaggc ctcccgagaa
     1261 ggcacggtga ccagccgcca ggtgcgcacc attgtggaag aagtccagga tggcaaggtg
     1321 gtctcctcca gggagcaggt gcaccgctcc acccactga
//
LOCUS       NM_001135687             672 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus similar to killer cell lectin-like receptor
            subfamily B member 1A (RGD2301395), mRNA.
ACCESSION   NM_001135687
VERSION     NM_001135687.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 672)
  AUTHORS   Kveberg,L., Dai,K.Z., Westgaard,I.H., Daws,M.R., Fossum,S.,
            Naper,C. and Vaage,J.T.
  TITLE     Two major groups of rat NKR-P1 receptors can be distinguished based
            on chromosomal localization, phylogenetic analysis and Clr ligand
            binding
  JOURNAL   Eur J Immunol 39 (2), 541-551 (2009)
   PUBMED   19130483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FJ158033.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ158033.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="AUG"
                     /db_xref="taxon:10116"
                     /chromosome="4"
     gene            1..672
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="similar to killer cell lectin-like receptor
                     subfamily B member 1A"
                     /db_xref="GeneID:100190921"
                     /db_xref="RGD:2301395"
     CDS             1..672
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="killer cell lectin-like receptor subfamily B member
                     1A-like"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1A"
                     /protein_id="NP_001129159.1"
                     /db_xref="GeneID:100190921"
                     /db_xref="RGD:2301395"
                     /translation="MDTARVYLSLKPSKTAAGAQCVSPPSLPPDACRCPRSHRLALKL
                     SCAGLILLVLALVGMSILVRVLVQKPSVEPCRVLIQENLSKTDSPAKLKCPKDWLSHR
                     DKCFHVSQASNTWKESLADCDGKGATLLLIQSQEELRFLRYLIKGKGSSFWIGLSYTL
                     PDRNWKWINGSTLNPDVLSIFGDTKQNSCASVSQDKVLSESCSSDNLWICQKELKCEC
                     MCNGS"
     misc_feature    280..636
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    280..636
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(451..453,532..534,586..588,592..597)
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     misc_feature    order(451..453,532..534,586..588,592..597)
                     /gene="RGD2301395"
                     /gene_synonym="Kl4b1a; Klrb1al"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
ORIGIN      
        1 atggacacag cacgtgtcta cctcagttta aagccatcca agactgccgc gggggctcag
       61 tgtgtatcac ctccatctct tcccccagat gcctgtcggt gcccacgttc acacaggttg
      121 gctttgaagc tcagctgcgc tgggctgatc cttcttgtct tggccctggt tgggatgagt
      181 attttagtgc gagtcttagt tcaaaaacca tcagtggagc catgccgagt gcttattcaa
      241 gagaacctga gtaaaacaga tagtccagct aagttaaagt gcccaaaaga ctggctttca
      301 caccgagata aatgctttca tgtttctcaa gcttctaata cttggaagga aagtctagct
      361 gactgtgatg gaaaaggagc cacgttgctg ctcattcaaa gccaagaaga actgagattc
      421 ctacggtact tgataaaggg aaaaggcagc tcattctgga ttggattaag ttacacattg
      481 ccagacagga actggaagtg gataaatggc tcgactttaa atcctgatgt attaagcata
      541 tttggtgaca ccaaacagaa cagctgtgcc tctgtctcac aggacaaagt gctttctgag
      601 agctgtagtt cagacaattt gtggatctgc caaaaggaac taaaatgtga atgcatgtgt
      661 aatggctcct ga
//
LOCUS       NM_001008750            1476 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus type I keratin KA11 (Ka11), mRNA.
ACCESSION   NM_001008750 XM_579201
VERSION     NM_001008750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004048.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579201.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004048.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1476
                     /gene="Ka11"
                     /note="type I keratin KA11"
                     /db_xref="GeneID:450226"
                     /db_xref="RGD:1359526"
     CDS             1..1476
                     /gene="Ka11"
                     /codon_start=1
                     /product="type I keratin KA11"
                     /protein_id="NP_001008750.1"
                     /db_xref="GeneID:450226"
                     /db_xref="RGD:1359526"
                     /translation="MATCNRQFTSSSCWKGSCGIGGGFSRMSSVLAGGSCRAPSTYGG
                     MSVTSSRFSSRGACGIGGGYGGRFSSSSFGGGIGGGLGGGIGGGLGGGIGGGLGGGIG
                     GGLGGGLGGGIGGGLGGGIGDGLGNGLLVGSEKVTMQNLNDRLSNYMDQVRALEKANS
                     DLEVKIRDWYQRQRPTELKDYRSHFRTIEDLKSQIMTATQENAQTNLQIDNARLAAND
                     FRTKYESELFLSQSVEIDVQNITKVLDDLGSIGADLEMQIQSLTEELAALNRNHQEEM
                     LALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDVEAWFQSKTEELNQ
                     EVASNHELIQSGRSEVSELRRVFQGLEIELQSQLSVKASLENSLEETKGRYCVQLSQI
                     QGLIGSLEEQLAQLRCEMEQQSQEYNILLDVKTRLEQEIATYRRLLDSENVHSSSSQH
                     SSGQSYSSGEVFSSSSRQPRSILKDQGSTSFSQSQSQSSGN"
     misc_feature    397..1323
                     /gene="Ka11"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     misc_feature    397..1323
                     /gene="Ka11"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:459643"
     exon            1..582
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            583..665
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            666..822
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            823..984
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1110
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1331
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1381
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1476
                     /gene="Ka11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccacct gcaaccgtca gttcacctcc tccagctgtt ggaagggctc ctgtggcatc
       61 ggtggtggct ttagccgcat gtcctcagtc ctggctggag gatcctgccg ggctcccagc
      121 acctatgggg gcatgtccgt cacctcctct cgtttctcct ctcggggagc ctgtgggatt
      181 ggaggtggct atggtgggcg cttcagcagc agcagttttg gtggtggtat tggtggagga
      241 cttggtggtg gtattggcgg aggacttggt ggtggtattg gtggtggtct tggtggtggt
      301 attggtggag gacttggtgg tggtcttggt ggtggtattg gtggaggact tggtggtggt
      361 attggtgatg ggcttggcaa tgggctcctg gtaggcagtg agaaagtgac catgcagaat
      421 ctcaatgatc gtttgtccaa ctacatggat caggtgcgtg ccctggaaaa ggccaacagt
      481 gacctggagg tgaagatccg ggactggtac cagaggcagc gtcccactga gcttaaagac
      541 tatcgttccc acttcaggac catcgaggac ctgaagagcc agatcatgac agccacacag
      601 gagaatgcac agaccaattt acagatcgac aatgccaggc tggcagctaa tgacttcagg
      661 accaagtatg agtctgagct gttcttgagt cagtccgtgg aaatagacgt ccaaaacata
      721 accaaggtgc tagatgacct gggctcaatt ggagccgacc tggagatgca gattcaaagc
      781 ctcacagagg agctggccgc cctgaatagg aatcaccagg aggagatgct tgccttgagg
      841 ggtcagactg gtggggacgt caacgtggag atggacgcag ctcctggtgt ggacctgagc
      901 cgcatcctga acgagatgag ggaccagtat gagcagatgg cagagaagaa ccgcagagat
      961 gtggaggcct ggttccagag caagaccgag gagctgaacc aagaggtggc ttctaaccat
     1021 gagctgatac agagcggccg cagcgaggtg tctgagctcc gcagggtgtt ccagggcctg
     1081 gagatagaac tgcagtccca gctcagcgtg aaagcatcct tggagaacag cctagaagag
     1141 accaaaggca gatactgcgt gcagctgtcc cagatccagg gtttgatcgg cagcctggag
     1201 gagcagctgg ctcagctgcg ctgcgagatg gagcagcaga gccaggagta caacatcttg
     1261 ttggatgtga agactcggct ggagcaggag atcgccacct accgccgtct gctggatagc
     1321 gagaatgtcc acagctcctc ctcacagcac tcctctgggc agtcctattc ttctggagaa
     1381 gtcttctcct catcctcccg gcagccccgg tccatcctca aggatcaagg ctcaaccagc
     1441 ttcagccaga gccaaagtca gagttccggg aactaa
//
LOCUS       NM_175602               1017 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 9 (Taar9), mRNA.
ACCESSION   NM_175602
VERSION     NM_175602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Murtazina,R.Z., Zhukov,I.S., Korenkova,O.M., Popova,E.A.,
            Kuvarzin,S.R., Efimova,E.V., Kubarskaya,L.G., Batotsyrenova,E.G.,
            Zolotoverkhaya,E.A., Vaganova,A.N., Apryatin,S.A., Alenina,N.V. and
            Gainetdinov,R.R.
  TITLE     Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in
            Rats Leads to Decreased Blood Cholesterol Levels
  JOURNAL   Int J Mol Sci 22 (6), 2942 (2021)
   PUBMED   33799339
  REMARK    GeneRIF: Genetic Deletion of Trace-Amine Associated Receptor 9
            (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Ferrero,D.M., Wacker,D., Roque,M.A., Baldwin,M.W., Stevens,R.C. and
            Liberles,S.D.
  TITLE     Agonists for 13 trace amine-associated receptors provide insight
            into the molecular basis of odor selectivity
  JOURNAL   ACS Chem Biol 7 (7), 1184-1189 (2012)
   PUBMED   22545963
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380190.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1017
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="trace amine-associated receptor 9"
                     /db_xref="GeneID:319107"
                     /db_xref="RGD:631383"
     CDS             1..1017
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="taR-3; taR-9; trace amine receptor 9; trace amine
                     receptor 3"
                     /codon_start=1
                     /product="trace amine-associated receptor 9"
                     /protein_id="NP_783192.1"
                     /db_xref="GeneID:319107"
                     /db_xref="RGD:631383"
                     /translation="MELCYENVNGSCIKSSYSPWPRAILYAVLGLGALLAVFGNLLVI
                     TAILHFKQLHTPTNFLVASLACADFLVGVTVMPFSTVRSVEGCWYFGDTYCKFHTCFD
                     TSFCFASLFHLCCISIDRYVAVTDPLTYPTKFTISVSGVCIALSWFFSVTYSFSIFYT
                     GANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLLFFLPTVVMVFLYGRIFLVAKQQA
                     RKIEGSANQPQASSESYKERVARRERKAAKTLGIAMAAFLVSWLPYIIDAVIDAYMNF
                     ITPAYVYEILVWCVYYNSAMNPLIYAFFYPWFRKAIKLIVSGKVFRADSSRTNLFSEE
                     AGAG"
     misc_feature    25..27
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y6.1); glycosylation site"
     misc_feature    70..936
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="trace amine-associated receptors 6, 8, and 9,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_TAAR6_8_9;
                     cd15316"
                     /db_xref="CDD:320439"
     misc_feature    70..936
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="trace amine-associated receptors 6, 8, and 9,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_TAAR6_8_9;
                     cd15316"
                     /db_xref="CDD:320439"
     misc_feature    70..150
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    70..150
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    70..144
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    169..249
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    169..249
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    175..240
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    283..375
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    283..375
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    286..354
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    order(292..294,304..309,316..321,544..546,562..564,
                     571..576,583..585,781..783,790..795,802..804,847..849,
                     859..861,871..873)
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320439"
     misc_feature    order(292..294,304..309,316..321,544..546,562..564,
                     571..576,583..585,781..783,790..795,802..804,847..849,
                     859..861,871..873)
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320439"
     misc_feature    409..480
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    409..480
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    415..480
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    490..531
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     Region: Extracellular Loop 2 (ECL2).
                     /evidence=ECO:0000250|UniProtKB:Q5QD04"
     misc_feature    550..639
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    550..639
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    559..624
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    721..813
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    721..813
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    739..810
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     misc_feature    838..915
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    838..915
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    850..912
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y6.1);
                     transmembrane region"
     exon            1..1017
                     /gene="Taar9"
                     /gene_synonym="Ta3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagctct gctacgagaa cgtgaatgga tcttgcatta aaagctccta ctcgccctgg
       61 cctcgagcca tcctctatgc ggtccttggt ttgggagccc tgctggcagt gtttgggaac
      121 ttactggtca tcaccgctat cctccacttt aaacagttgc acacgcctac aaactttctg
      181 gtggcctcgc tggcctgtgc tgacttcttg gtgggggtga ctgtgatgcc ctttagcacg
      241 gtgcggtctg tggagggctg ctggtacttt ggggacactt actgtaagtt ccacacgtgt
      301 ttcgacacct ccttctgctt tgcgtctctg tttcacttat gctgcatctc cattgacagg
      361 tacgttgcag tcaccgaccc actgacctat ccgaccaagt tcaccatttc ggtttctggc
      421 gtgtgcatcg ctctctcgtg gttcttttct gtcacctaca gcttttccat cttttacaca
      481 ggagccaacg aggaagggat tgaggaacta gtggttgctc tgacctgtgt gggaggctgc
      541 caggctccac tgaatcagaa ttgggtttta ctttgtttcc ttttgttctt tctgcccact
      601 gtcgtcatgg tgtttctcta tggtcggata tttttggtgg cgaagcaaca ggctaggaag
      661 atagagggtt cggccaacca accccaggcc tcctctgaga gctacaagga aagagtagcc
      721 agacgagaga ggaaggcggc caaaaccttg gggatcgcca tggctgcatt tctcgtgtcc
      781 tggctgccat acattatcga tgccgtgatt gatgcctaca tgaacttcat aactcctgcc
      841 tacgtctatg agatattagt gtggtgtgtt tactataatt cagctatgaa ccctttgata
      901 tatgccttct tttatccttg gtttcgcaag gcaataaaac ttattgtgag tggcaaagtc
      961 ttcagggctg actcatcaag aactaatctg ttctctgaag aagcaggtgc aggttaa
//
LOCUS       NM_001024805             444 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus hemoglobin, epsilon 2 (Hbe2), mRNA.
ACCESSION   NM_001024805 XM_577830
VERSION     NM_001024805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Satoh,H., Inokuchi,N., Nagae,Y. and Okazaki,T.
  TITLE     Molecular cloning and characterization of two sets of alpha-theta
            genes in the rat alpha-like globin gene cluster
  JOURNAL   Gene 230 (1), 91-99 (1999)
   PUBMED   10196478
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Iwahara,S.I., Abe,Y. and Okazaki,T.
  TITLE     Identification of five embryonic hemoglobins of rat and ontogeny of
            their constituent globins during fetal development
  JOURNAL   J Biochem 119 (2), 360-366 (1996)
   PUBMED   8882731
REFERENCE   3  (bases 1 to 444)
  AUTHORS   Kohli-Kumar,M., Zwerdling,T. and Rucknagel,D.L.
  TITLE     Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a
            newborn with cyanosis
  JOURNAL   Am J Hematol 49 (1), 43-47 (1995)
   PUBMED   7741137
REFERENCE   4  (bases 1 to 444)
  AUTHORS   Miller,B.A., Olivieri,N., Salameh,M., Ahmed,M., Antognetti,G.,
            Huisman,T.H., Nathan,D.G. and Orkin,S.H.
  TITLE     Molecular analysis of the high-hemoglobin-F phenotype in Saudi
            Arabian sickle cell anemia
  JOURNAL   N Engl J Med 316 (5), 244-250 (1987)
   PUBMED   2432426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X56327.1.
            
            On Jun 10, 2005 this sequence version replaced XM_577830.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680427,
                              SAMN06680431 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..444
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="hemoglobin, epsilon 2"
                     /db_xref="GeneID:502359"
                     /db_xref="RGD:1564524"
     CDS             1..444
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="epsilon 2 globin; globin b3"
                     /codon_start=1
                     /product="hemoglobin subunit epsilon"
                     /protein_id="NP_001019976.1"
                     /db_xref="GeneID:502359"
                     /db_xref="RGD:1564524"
                     /translation="MVHFTAEEKAAIISIWEKVDLEKLGGETLGRLLIVYPWTQRFFD
                     KFGNLSSAPAIMGNPQIRAHGKKVLVSLGLAVENMDNLKETFAHLSELHCDKLHVDPE
                     NFKLLGNVLVIVLSSYFGKEFTAEVQAAWQKLVAGVATALSHKYH"
     misc_feature    22..438
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="Hemoglobin beta, gamma, delta, epsilon, and related
                     Hb subunits; Region: Hb-beta-like; cd08925"
                     /db_xref="CDD:381262"
     misc_feature    22..438
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="Hemoglobin beta, gamma, delta, epsilon, and related
                     Hb subunits; Region: Hb-beta-like; cd08925"
                     /db_xref="CDD:381262"
     misc_feature    order(91..93,100..105,112..114,121..123,292..294,298..300,
                     307..309,325..327,334..339,346..351,358..360,367..375,
                     382..387,394..396)
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381262"
     misc_feature    order(91..93,100..105,112..114,121..123,292..294,298..300,
                     307..309,325..327,334..339,346..351,358..360,367..375,
                     382..387,394..396)
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381262"
     misc_feature    order(94..96,124..129,190..192,199..204,211..213,265..267,
                     277..279,289..291,295..297,307..312,319..321,424..426)
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:381262"
     misc_feature    order(94..96,124..129,190..192,199..204,211..213,265..267,
                     277..279,289..291,295..297,307..312,319..321,424..426)
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:381262"
     exon            1..92
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            93..315
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..444
                     /gene="Hbe2"
                     /gene_synonym="Glnb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggttcact tcacagctga ggagaaggct gctatcataa gcatatggga aaaagtggac
       61 ttggaaaaac ttggaggaga aaccctggga aggctcctca ttgtatatcc atggactcag
      121 agattctttg acaagtttgg aaacctctct tctgctccgg ccatcatggg taatccccag
      181 atcagagccc atggcaagaa agtgctggtg tccctaggct tggcagttga gaacatggac
      241 aacctcaagg agacctttgc tcatctgagt gagctgcact gtgacaagct tcacgtggat
      301 cccgagaact ttaagctcct gggtaacgtg ctggtgattg ttctttcttc ttacttcggc
      361 aaagaattca cagctgaggt gcaggctgcc tggcagaagc tggtggctgg ggtggccact
      421 gctctgtccc acaagtacca ctga
//
LOCUS       NM_001107976            1156 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus 5'-nucleotidase, cytosolic IA (Nt5c1a), mRNA.
ACCESSION   NM_001107976 XM_001055008 XM_233494
VERSION     NM_001107976.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Kulkarni,S.S., Karlsson,H.K., Szekeres,F., Chibalin,A.V., Krook,A.
            and Zierath,J.R.
  TITLE     Suppression of 5'-nucleotidase enzymes promotes AMP-activated
            protein kinase (AMPK) phosphorylation and metabolism in human and
            mouse skeletal muscle
  JOURNAL   J Biol Chem 286 (40), 34567-34574 (2011)
   PUBMED   21873433
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Kaizer,R.R., Maldonado,P.A., Spanevello,R.M., Correa,M.C.,
            Goncalves,J.F., Becker,L.V., Morsch,V.M. and Schetinger,M.R.
  TITLE     The effect of aluminium on NTPDase and 5'-nucleotidase activities
            from rat synaptosomes and platelets
  JOURNAL   Int J Dev Neurosci 25 (6), 381-386 (2007)
   PUBMED   17686601
  REMARK    GeneRIF: Al increases NTPDase and 5'-nucleotidase activities, in
            synaptosomal fractions and platelets. Thus, we suggest that
            platelets could be sensitive peripheral markers of Al toxicity of
            the central nervous system.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Mackiewicz,M., Nikonova,E.V., Zimmerman,J.E., Galante,R.J.,
            Zhang,L., Cater,J.R., Geiger,J.D. and Pack,A.I.
  TITLE     Enzymes of adenosine metabolism in the brain: diurnal rhythm and
            the effect of sleep deprivation
  JOURNAL   J Neurochem 85 (2), 348-357 (2003)
   PUBMED   12675911
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Hunsucker,S.A., Spychala,J. and Mitchell,B.S.
  TITLE     Human cytosolic 5'-nucleotidase I: characterization and role in
            nucleoside analog resistance
  JOURNAL   J Biol Chem 276 (13), 10498-10504 (2001)
   PUBMED   11133996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233494.4, XM_001055008.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1156
                     /gene="Nt5c1a"
                     /note="5'-nucleotidase, cytosolic IA"
                     /db_xref="GeneID:313574"
                     /db_xref="RGD:1310908"
     exon            1..193
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1156
                     /gene="Nt5c1a"
                     /EC_number="3.1.3.5"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 1A"
                     /protein_id="NP_001101446.1"
                     /db_xref="GeneID:313574"
                     /db_xref="RGD:1310908"
                     /translation="MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPK
                     PQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEA
                     VNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYL
                     KAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDES
                     ERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYL
                     VTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGA
                     QEMGTVAAHVPYGVAQNPRREKQSLGAQ"
     misc_feature    299..1117
                     /gene="Nt5c1a"
                     /note="5'-nucleotidase; Region: 5-nucleotidase; pfam06189"
                     /db_xref="CDD:461846"
     misc_feature    299..1117
                     /gene="Nt5c1a"
                     /note="5'-nucleotidase; Region: 5-nucleotidase; pfam06189"
                     /db_xref="CDD:461846"
     exon            194..361
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            362..491
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            492..614
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            615..799
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1156
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccttgag ctccctgtct ccgacgctgt cttctcccgc ccggccggat cggatccgag
       61 ccggaacatg gaaccaaggc agcccccgga ggcccgagaa cccggaccag gggcagagac
      121 cgccgcggtg ccgcgctggg aggaagccaa gacgttctat gacaatctct cgcccaagaa
      181 gaaacccaaa tcgccaaagc ctcagaatgc ggtcaccatc gcagtgtcct ccagagcctt
      241 gttccgaatg gatgaggaac agaggatcta cacggagcag ggtgtagagg agtacgtacg
      301 ataccagctg gagcacgaga acgagccctt cagccctggg cccgccttcc cctttgtaaa
      361 ggccctggag gctgtgaaca agcaacttcg agagctgtac cccgatagcg aagatatctt
      421 tgacatcgtc ctcatgacca acaaccatgc tcaggtgggg gttcgtctca tcaacagtat
      481 caaccattac gacctgttca ttgagcgatt ctgcatgaca ggtgggaata gccccatctg
      541 ctacctcaag gcctaccata ccaacctcta cttgtcagcc gatgcagaaa aagtgcgaga
      601 agccattgat gaggggattg cagctgccac catcttcagc cctagcaagg atgtggtcgt
      661 gtcccagagt cagctccgcg tggccttcga tggggacgca gtacttttct ccgatgagtc
      721 agagcgcatt gtcaaggccc atgggctgga cagattcttt gagcatgaga aggcccacga
      781 gaacaaacct ttggcgcagg gtcccctaaa gggcttcctg gaagcactag gtaggctgca
      841 gaagaaattc tactccaaag gcctgcggct ggagtgcccg attcgtactt acttggtgac
      901 agcgcgcagc gcagccagtt ctggagcccg ggccctcaag accctacgta gctggggcct
      961 ggagacggat gaggccttat tcctagctgg agcacccaag ggccctcttc ttgagaagat
     1021 ccgcccacac atcttctttg atgaccagat gtttcacgtg gccggagctc aggagatggg
     1081 caccgtggcc gcccacgtgc cttacggcgt agctcagaat ccacggaggg aaaagcagtc
     1141 cctaggcgca cagtag
//
LOCUS       NM_206848               1107 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class Ib, locus Cl (RT1-Cl), mRNA.
ACCESSION   NM_206848 XM_003754674
VERSION     NM_206848.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Lambracht,D. and Wonigeit,K.
  TITLE     Sequence analysis of the promoter regions of the classical class I
            gene RT1.Al and two other class I genes of the rat MHC
  JOURNAL   Immunogenetics 41 (6), 375-379 (1995)
   PUBMED   7759134
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Tiedke,J., Bielski,C., Kinas,J. and Marquardt,B.
  TITLE     Dialysis treatment: are patients aware of their options?
  JOURNAL   Nephrol News Issues 6 (11), 52-53 (1992)
   PUBMED   1300430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF025308.1.
            
            On Jun 26, 2012 this sequence version replaced XM_003754674.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20"
     gene            1..1107
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="RT1 class Ib, locus Cl"
                     /db_xref="GeneID:24977"
                     /db_xref="RGD:3472"
     CDS             1..1107
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="MHC class I antigen; RT1 class Ib gene,
                     RT1-C-region (CI)"
                     /codon_start=1
                     /product="RT1 class Ib, locus Cl precursor"
                     /protein_id="NP_996730.1"
                     /db_xref="GeneID:24977"
                     /db_xref="RGD:3472"
                     /translation="MAPRTLLLLLAAALAPTQVRAGSHSLRYFHTAVSRPGLGEPRFI
                     IVGYVDDTEFVRYDSDAENPRYEPRVGWMEREGPEYWERETLMVKENEQVYRVSLRTL
                     LRYYNQSEGGSHTIQWMSGCDVGSDGSLLRGYDQFAYDGRDYLALNEDLKTWMAADTA
                     AQMTRNKWDQAGEAERHKAYLQGTCVEWLRRYLELGKETLLRSDPPKAHVTLHPRPEG
                     DVTLRCWALGFYPAGIFLTWLLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQ
                     NYTCLVEHEGLPDPLTLRWEAPPSTDPNMETTVIYVVVGAVVITGAVTMIGALLTVVR
                     GRKRNTGGKVGVYTPAPGKDSSESSDVSLPDCKA"
     sig_peptide     1..63
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    64..600
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; pfam00129"
                     /db_xref="CDD:395078"
     misc_feature    64..600
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; pfam00129"
                     /db_xref="CDD:395078"
     misc_feature    604..888
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    604..888
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    658..672
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    658..672
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    703..717
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    703..717
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    796..810
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    796..810
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    829..846
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    829..846
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    874..885
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    874..885
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1018..1101
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="MHC_I C-terminus; Region: MHC_I_C; pfam06623"
                     /db_xref="CDD:461964"
     misc_feature    1018..1101
                     /gene="RT1-Cl"
                     /gene_synonym="RT1.A"
                     /note="MHC_I C-terminus; Region: MHC_I_C; pfam06623"
                     /db_xref="CDD:461964"
ORIGIN      
        1 atggcaccgc gcacgctgct cctgctgctg gcggccgccc tggccccgac ccaggttcgc
       61 gcgggctcac actcgctgcg gtatttccac accgccgtgt cccggcccgg cctcggggag
      121 ccccggttca ttatcgtcgg ctacgtggac gacacggagt tcgtgcgcta cgacagcgac
      181 gcggagaatc cgagatacga gccgcgggtt gggtggatgg agcgggaggg tccggagtat
      241 tgggagcggg agacactgat ggtcaaggaa aacgagcagg tttaccgagt gagcctgagg
      301 accctgctcc gctactacaa ccagagcgag ggcggctctc acaccatcca gtggatgtcc
      361 ggctgtgacg tggggtcgga cgggagcctc ctccgcgggt atgatcagtt cgcctacgac
      421 ggccgcgatt acctcgccct gaacgaagac ctgaaaacgt ggatggcggc ggacacggcg
      481 gcacagatga cccgaaacaa gtgggatcag gcaggtgaag cagagagaca caaggcctac
      541 ctgcagggca cgtgtgtgga gtggctccgc agatacctgg agctcgggaa ggagacgctg
      601 ctgcgctcag atcccccaaa ggcacatgtg acccttcacc ccagacctga aggtgatgtc
      661 accctgaggt gctgggccct gggcttctac cctgctggca tattcctgac ctggctgttg
      721 aatggggagg atctgaccca ggacatggag cttgtggaga ccaggcctgc aggggatgga
      781 accttccaga agtgggcatc tgtggtggtg cctcttggga aggagcagaa ttacacatgc
      841 cttgtggagc atgaggggct gcctgatcct ctcaccctga gatgggaggc tcctccatcc
      901 actgacccca acatggaaac cactgtcatt tatgttgtcg ttggagctgt ggtcatcact
      961 ggagctgtga ccatgattgg agctctgctg actgttgtga gggggaggaa gagaaacaca
     1021 ggtgggaaag taggagtcta cacccctgct ccaggcaagg acagctccga gagctctgat
     1081 gtgtctctcc cagattgtaa agcatga
//
LOCUS       NM_053405               1191 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 9 (Kcnk9), mRNA.
ACCESSION   NM_053405
VERSION     NM_053405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Garcia,G., Noriega-Navarro,R., Martinez-Rojas,V.A.,
            Gutierrez-Lara,E.J., Oviedo,N. and Murbartian,J.
  TITLE     Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain
  JOURNAL   Eur J Pharmacol 862, 172631 (2019)
   PUBMED   31472119
  REMARK    GeneRIF: Study analyzed TASK-1 and TASK-3 expression in ipsilateral
            and contralateral dorsal root ganglia and dorsal and ventral spinal
            cord of naive and formalin-treated or nerve injured rats.
            Pharmacological and molecular data suggest that TASK-1 and TASK-3
            reduce the nociceptive transmission in acute/chronic inflammatory
            and neuropathic pain suggesting antinociceptive role of these
            channels in inflammatory and neuropathic pain.
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Zhang,H., Dong,H., Cilz,N.I., Kurada,L., Hu,B., Wada,E.,
            Bayliss,D.A., Porter,J.E. and Lei,S.
  TITLE     Neurotensinergic Excitation of Dentate Gyrus Granule Cells via
            Galphaq-Coupled Inhibition of TASK-3 Channels
  JOURNAL   Cereb Cortex 26 (3), 977-990 (2016)
   PUBMED   25405940
  REMARK    GeneRIF: results demonstrate that neurotensin (NT) transiently
            increased the neuronal excitability of dentate gyrus granule cells
            (GCs) by inhibiting TASK-3 channels; NT-mediated increases in
            neuronal excitability facilitate long-term potentiation at the
            perforant path-GC synapses
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Kubota,K., Ohtake,N., Ohbuchi,K., Mase,A., Imamura,S., Sudo,Y.,
            Miyano,K., Yamamoto,M., Kono,T. and Uezono,Y.
  TITLE     Hydroxy-alpha sanshool induces colonic motor activity in rat
            proximal colon: a possible involvement of KCNK9
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (7), G579-G590 (2015)
   PUBMED   25634809
  REMARK    GeneRIF: Hydroxy-alpha sanshool evokes colonic motility via
            blockage of the neural KCNK9 channel in the colonic myenteric
            plexus.
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Marinc,C., Derst,C., Pruss,H. and Veh,R.W.
  TITLE     Immunocytochemical localization of TASK-3 protein (K2P9.1) in the
            rat brain
  JOURNAL   Cell Mol Neurobiol 34 (1), 61-70 (2014)
   PUBMED   24077856
  REMARK    GeneRIF: the entire rat brain was immunocytochemically analyzed for
            expression of TASK-3 protein.
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Blankenship,M.L., Coyle,D.E. and Baccei,M.L.
  TITLE     Transcriptional expression of voltage-gated Na and
            voltage-independent K channels in the developing rat superficial
            dorsal horn
  JOURNAL   Neuroscience 231, 305-314 (2013)
   PUBMED   23219908
  REMARK    GeneRIF: In the dorsal horn of the developing rat, TWIK-related
            acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were
            down-regulated during postnatal development
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Czirjak,G. and Enyedi,P.
  TITLE     TASK-3 dominates the background potassium conductance in rat
            adrenal glomerulosa cells
  JOURNAL   Mol Endocrinol 16 (3), 621-629 (2002)
   PUBMED   11875121
  REMARK    GeneRIF: TASK-3 dominates the resting potassium conductance of zona
            glomerulosa cells
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Karschin,C., Wischmeyer,E., Preisig-Muller,R., Rajan,S., Derst,C.,
            Grzeschik,K.H., Daut,J. and Karschin,A.
  TITLE     Expression pattern in brain of TASK-1, TASK-3, and a tandem pore
            domain K(+) channel subunit, TASK-5, associated with the central
            auditory nervous system
  JOURNAL   Mol Cell Neurosci 18 (6), 632-648 (2001)
   PUBMED   11749039
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Vega-Saenz de Miera,E., Lau,D.H., Zhadina,M., Pountney,D.,
            Coetzee,W.A. and Rudy,B.
  TITLE     KT3.2 and KT3.3, two novel human two-pore K(+) channels closely
            related to TASK-1
  JOURNAL   J Neurophysiol 86 (1), 130-142 (2001)
   PUBMED   11431495
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   Chapman,C.G., Meadows,H.J., Godden,R.J., Campbell,D.A.,
            Duckworth,M., Kelsell,R.E., Murdock,P.R., Randall,A.D., Rennie,G.I.
            and Gloger,I.S.
  TITLE     Cloning, localisation and functional expression of a novel human,
            cerebellum specific, two pore domain potassium channel
  JOURNAL   Brain Res Mol Brain Res 82 (1-2), 74-83 (2000)
   PUBMED   11042359
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Kim,Y., Bang,H. and Kim,D.
  TITLE     TASK-3, a new member of the tandem pore K(+) channel family
  JOURNAL   J Biol Chem 275 (13), 9340-9347 (2000)
   PUBMED   10734076
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF391084.1.
            
            On Dec 5, 2007 this sequence version replaced NM_053405.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF391084.1, AF192366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="potassium two pore domain channel subfamily K
                     member 9"
                     /db_xref="GeneID:84429"
                     /db_xref="RGD:621451"
     CDS             1..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="two pore potassium channel KT3.2; TWIK-related
                     acid-sensitive K(+) channel 3; acid-sensitive potassium
                     channel protein TASK-3; two pore K(+) channel KT3.2;
                     potassium channel, subfamily K, member 9 (Task-3);
                     potassium channel, two pore domain subfamily K, member 9;
                     potassium channel subfamily K member 9"
                     /codon_start=1
                     /product="potassium channel subfamily K member 9
                     precursor"
                     /protein_id="NP_445857.2"
                     /db_xref="GeneID:84429"
                     /db_xref="RGD:621451"
                     /translation="MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAE
                     EVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPG
                     TDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMV
                     TVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKP
                     FYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVP
                     QSRKRHHPMYFLRKYGRTLCYLCFPGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAA
                     AATPGPSTRNVRATVHSVSCRVEEIPPDVLRNTYFRSPFGAIPPGMHTCGENHRLHIR
                     RKSI"
     sig_peptide     1..81
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    25..87
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     transmembrane region"
     misc_feature    157..159
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ES08.2); glycosylation site"
     misc_feature    <217..396
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:462301"
     misc_feature    <217..396
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:462301"
     misc_feature    232..234
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="Forms a cation-pi interaction with protonated H-98,
                     stabilizing the C-type inactivated state.
                     /evidence=ECO:0000250|UniProtKB:Q9NPC2; propagated from
                     UniProtKB/Swiss-Prot (Q9ES08.2); other site"
     misc_feature    277..294
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     Region: Selectivity filter 1.
                     /evidence=ECO:0000250|UniProtKB:Q9NPC2"
     misc_feature    292..294
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="pH sensor. /evidence=ECO:0000250|UniProtKB:Q9NPC2;
                     propagated from UniProtKB/Swiss-Prot (Q9ES08.2); other
                     site"
     misc_feature    322..384
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     transmembrane region"
     misc_feature    475..537
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     transmembrane region"
     misc_feature    <550..729
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:462301"
     misc_feature    <550..729
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:462301"
     misc_feature    595..612
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     Region: Selectivity filter 2.
                     /evidence=ECO:0000250|UniProtKB:Q9NPC2"
     misc_feature    655..717
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     transmembrane region"
     misc_feature    727..744
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES08.2);
                     Region: X-gate. /evidence=ECO:0000250|UniProtKB:Q9NPC2"
     exon            1..283
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagcggc agaacgtgcg taccctgtcc ttgatcgcct gtaccttcac ctacctgctg
       61 gtgggtgccg cggtgttcga cgccctcgag tcggaccatg agatgcgcga ggaggagaaa
      121 cttaaagcag aagaggtccg cctcagaggc aagtacaaca tcagctccga tgactaccag
      181 cagctggagc tggtaatcct gcagtctgag ccccaccgcg ctggtgtcca gtggaagttc
      241 gccgggtcct tctacttcgc tatcactgtc atcacaacta tcggatatgg acatgctgca
      301 cctggaaccg atgctggcaa ggccttctgt atgttctatg ctgtgctggg tatccctctg
      361 acgctggtta tgttccagag cctgggcgag cgcatgaaca ccttcgtgcg ctacctgctg
      421 aaacggatca agaagtgctg tggcatgcgc aacactgaag tttctatgga gaacatggtg
      481 accgtcggct tcttttcttg catgggcacc ctgtgccttg gggcggctgc cttttcccag
      541 tgcgaagatt ggagcttctt ccacgcttac tactactgct tcattacact gactactata
      601 gggttcggcg actttgtggc cctgcaatcc aagggtgccc tgcagaggaa gccattctac
      661 gtggccttca gcttcatgta tatcctggtg ggcctgaccg tcatcggtgc cttcctcaat
      721 cttgtggtcc tgcgattcct gaccatgaat accgatgaag atcttctgga gggagaagtt
      781 gcgcagatac ttgctggaaa cccaagacgg gtggttgtcc gtgtgcctca gagtcgcaag
      841 aggcaccacc ccatgtactt cctcaggaaa tacggccgaa ccctgtgcta tctctgcttc
      901 cctggtgcca actggggtga tgatgatgac gatgatgatg acgccgtcga gaatgtcgta
      961 gttactactc ctgttcctcc tgctgttgct gctgctgctg ctgctgctac tcctggtccc
     1021 agtaccagga atgtccgggc tacagtccac tcggtttcct gcagggttga agagatccct
     1081 ccggacgtgc tgaggaacac ctacttccgg tccccattcg gcgccatccc tcctggaatg
     1141 cacacctgcg gggaaaacca caggctgcac atccgtcgca agtccatcta a
//
LOCUS       NM_173336               1002 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 123 (Tas2r123),
            mRNA.
ACCESSION   NM_173336
VERSION     NM_173336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   3  (bases 1 to 1002)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   4  (bases 1 to 1002)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   5  (bases 1 to 1002)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   6  (bases 1 to 1002)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF240765.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF240765.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1002
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="taste receptor, type 2, member 123"
                     /db_xref="GeneID:287003"
                     /db_xref="RGD:727880"
     CDS             1..1002
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="T2R2; T2R23; T2R123; taste receptor type 2 member
                     2; taste receptor type 2 member 23; taste receptor, type
                     2, member 14; taste receptor rT2R2"
                     /codon_start=1
                     /product="taste receptor type 2 member 123"
                     /protein_id="NP_775458.1"
                     /db_xref="GeneID:287003"
                     /db_xref="RGD:727880"
                     /translation="MFSQKTNYSHLFTFSIIFYVEIVTGILGNGFIALVNIMDWLKRR
                     RISTADQILTALALTRLIYVWSVLICILLLFLCPHLSMRPEMFTAIGVIWVVDNHFSI
                     WLATCLGVFYFLKIASFSNSLFLYLKWRVKKVVLMIILISLIFLMLNISSLGMYDHFS
                     IDVYEGNMSYNLVDSTHFPRIFLFTNSSKVFLIANSSHVFLPINSLFMLIPFTVSLVA
                     FFVLFLSLWKHHKKMQVNAKGPRDASTMAHTKALQIGFSFLLLYAIYLLFIITGILNL
                     DLMRCIVILLFDHISGAVFSISHSFVLILGNSKLRQATLSVLPCLRCRSKDMDTVVF"
     misc_feature    37..954
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    37..954
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    37..114
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    37..114
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    43..111
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    148..222
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    148..222
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    172..231
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    262..330
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    262..330
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    274..342
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    400..468
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    409..459
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    409..459
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    499..501
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKF0.1); glycosylation site"
     misc_feature    535..660
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    535..660
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    556..558
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKF0.1); glycosylation site"
     misc_feature    583..585
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKF0.1); glycosylation site"
     misc_feature    613..681
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    733..810
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    733..810
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    751..819
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     misc_feature    844..921
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    844..921
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    847..915
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKF0.1);
                     transmembrane region"
     exon            1..1002
                     /gene="Tas2r123"
                     /gene_synonym="Tas2r14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttctcac agaaaacaaa ctacagccat ttgtttactt tttcaattat tttttatgtg
       61 gaaatagtaa caggaatctt aggaaatgga ttcatagcac tagtgaatat catggactgg
      121 ctcaagagga ggaggatctc tactgcagat cagattctca ctgctttggc ccttaccaga
      181 ctcatttatg tgtggtctgt actcatttgt atattgttac tatttctgtg cccacatttg
      241 tctatgagac cagaaatgtt tacagcgata ggtgttatct gggtagtgga taaccacttc
      301 agcatctggc ttgctacatg tcttggtgtc ttttatttcc tcaaaatagc cagtttttct
      361 aactctttgt ttctttacct aaagtggaga gttaaaaaag tggttttaat gataatactg
      421 atatcactga ttttcttgat gttaaacatt tcatcattag ggatgtatga tcatttctca
      481 attgatgttt atgaaggtaa tatgtcttat aatttggtgg attcaacaca ttttcccaga
      541 attttcttat tcacaaactc atctaaggtc ttcttaatcg ccaattcatc ccatgttttc
      601 ttacccatca actcactctt catgctcata cccttcacag tttccctggt agcttttttc
      661 gtgctctttc tctcactgtg gaagcatcac aagaagatgc aggtcaatgc caaaggaccc
      721 agagatgcca gcaccatggc ccacacaaaa gccttgcaaa ttgggttctc cttcctcctg
      781 ctgtatgcaa tatacttact tttcattatc acaggaattt tgaaccttga cttgatgaga
      841 tgtatagtaa tacttttatt tgaccacata tctggagcag ttttttctat aagccactca
      901 tttgtgctga ttctgggaaa cagtaagctg agacaagcca ctctttctgt gctgccttgt
      961 cttaggtgcc ggtccaaaga tatggacact gtcgttttct aa
//
LOCUS       NM_023997                918 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 121 (Tas2r121),
            mRNA.
ACCESSION   NM_023997
VERSION     NM_023997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   8  (bases 1 to 918)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227144.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227144.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..918
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="taste receptor, type 2, member 121"
                     /db_xref="GeneID:78983"
                     /db_xref="RGD:620738"
     CDS             1..918
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="T2R13; taste receptor type 2 member 7; taste
                     receptor T2R7"
                     /codon_start=1
                     /product="taste receptor type 2 member 13"
                     /protein_id="NP_076487.1"
                     /db_xref="GeneID:78983"
                     /db_xref="RGD:620738"
                     /translation="MGSSLYDILTIVMIAEFIFGNVTNGFIVLTNCIAWLSKRTLSFI
                     GWIQLFLAISRVVLIWEMLLAWLKYMKYSFSYLAGTELRVMMLTWVVSNHFSLWLATI
                     LSIFYLLKIASFSRPVFLYLKWRVKKVLLLILLGNLIFLMFNILQINTHIEDWMDQYK
                     RNITWDSRVNEFVGFSNLVLLEMIMFSVTPFTVALVSFILLIFSLWKHLQKMHLSSRG
                     ERDPSTKAHVNALRIMVSFLLLYATYFISFFISLIPMAHKKGLDLMFSLTVGLFYPSS
                     HSFILILGHSNLRHSSCLVITYLRCKEKD"
     misc_feature    22..876
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..876
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..84
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    25..99
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    25..99
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    127..189
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    133..198
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    133..198
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    265..327
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    394..444
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    394..444
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    484..486
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT7.1); glycosylation site"
     misc_feature    526..597
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    526..597
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    547..609
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    679..747
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    679..747
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    697..759
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     misc_feature    778..855
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    778..855
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    787..849
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT7.1);
                     transmembrane region"
     exon            1..918
                     /gene="Tas2r121"
                     /gene_synonym="T2R7; Tas2r13; Tas2r7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaagca gcctgtatga tatcttaact attgtcatga ttgcagagtt tatattcgga
       61 aatgtgacca atggattcat agtgctgaca aactgtattg cttggctcag taaaagaact
      121 ctttctttca ttggttggat ccagcttttc ttggccattt ccagagtggt tttgatatgg
      181 gaaatgttac tagcatggct gaaatatatg aagtattcat tttcatattt ggctggcaca
      241 gaattaaggg ttatgatgtt gacctgggta gtttccaatc actttagtct ctggcttgcc
      301 accattctaa gcatctttta tttgctcaaa atagctagtt tctccagacc tgttttcctg
      361 tatctgaagt ggagagtaaa aaaagtgctc ctgctgattc ttctcggaaa tttaatcttc
      421 ctgatgttca atatattaca aatcaacact cacatagaag actggatgga tcaatataag
      481 agaaatataa cgtgggattc cagagtgaat gaatttgtgg ggttttcaaa tctggtttta
      541 ttggagatga ttatgttctc tgtaacacca ttcaccgtgg ctctggtctc cttcatcctg
      601 ttaatcttct ctttatggaa acatctccag aagatgcatc tcagttccag aggggaacga
      661 gaccctagca caaaagccca tgtgaatgcc ctgagaatta tggtctcctt cctcttactc
      721 tatgccactt acttcatatc cttttttata tcattaattc ctatggcaca taaaaaagga
      781 ctagatctta tgtttagcct aactgttgga cttttctacc cttcaagcca ctcatttatc
      841 ttgattttgg gacattctaa tctaaggcat tccagttgtc tggtgataac ctatctgaga
      901 tgtaaggaaa aggattag
//
LOCUS       NM_001080905             960 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 139 (Tas2r139),
            mRNA.
ACCESSION   NM_001080905 XM_001056060
VERSION     NM_001080905.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362751.1.
            
            On Jan 30, 2007 this sequence version replaced XM_001056060.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..960
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="taste receptor, type 2, member 139"
                     /db_xref="GeneID:680188"
                     /db_xref="RGD:1595436"
     CDS             1..960
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="putative taste receptor T2R32; T2R39; taste
                     receptor type 2 member 32; taste receptor, type 2, member
                     39"
                     /codon_start=1
                     /product="taste receptor type 2 member 39"
                     /protein_id="NP_001074374.1"
                     /db_xref="GeneID:680188"
                     /db_xref="RGD:1595436"
                     /translation="MAQPSNYWKQDLLPLSILILTLVATECTIGIIASGIITVVNAVS
                     WVQKRAVSITTRILLLLSVSRIGLQSIILIEMTSSIFNFSSYNSVLYRVSRVSFVFLN
                     YCSLWFAALLSFFHFVKIANFSYPLFFKLKWRISELMPWLLWLSVFISFSSSMFFCNH
                     KYTVYNNISLSSNICNFTMELYVAEANVVNVAFLFSFGILPPLTMFIATATLLIFSLR
                     RHTLHMRNGDADSRNPRVEAHKQAIKETSCFLFLYILYAAVLFLSTSNIADASLFWSS
                     VLRISLPVYPAGHSVLLIQSNPGLKRTWKQLLSQIHLHLQSRY"
     misc_feature    49..915
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="mammalian taste receptor 2, subtype 39, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R39; cd15015"
                     /db_xref="CDD:320143"
     misc_feature    49..915
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="mammalian taste receptor 2, subtype 39, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R39; cd15015"
                     /db_xref="CDD:320143"
     misc_feature    49..111
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    52..129
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320143"
     misc_feature    52..129
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320143"
     misc_feature    163..237
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320143"
     misc_feature    163..237
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320143"
     misc_feature    169..231
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    244..246
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ER9.1); glycosylation site"
     misc_feature    274..342
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320143"
     misc_feature    274..342
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320143"
     misc_feature    292..354
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    412..474
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    421..471
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320143"
     misc_feature    421..471
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320143"
     misc_feature    499..501
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ER9.1); glycosylation site"
     misc_feature    526..528
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ER9.1); glycosylation site"
     misc_feature    562..633
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320143"
     misc_feature    562..633
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320143"
     misc_feature    562..624
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    706..783
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320143"
     misc_feature    706..783
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320143"
     misc_feature    742..804
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     misc_feature    814..891
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320143"
     misc_feature    814..891
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320143"
     misc_feature    820..882
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER9.1);
                     transmembrane region"
     exon            1..960
                     /gene="Tas2r139"
                     /gene_synonym="Tas2r39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgcaac ccagcaacta ttggaaacaa gatttgctac cactgtccat cttgatccta
       61 acacttgtgg ccactgagtg caccataggt atcattgcaa gtgggatcat cacagttgtg
      121 aatgcagtgt catgggttca gaaaagggca gtttccataa ctactaggat tctgcttctt
      181 ctgagcgtat ccagaatagg cctccaaagc atcatcttga tagaaatgac ttcctccata
      241 ttcaactttt cttcttacaa cagtgtttta tatagagtct caagggtaag ctttgtattc
      301 ctaaattatt gtagcctctg gtttgctgct ttgcttagtt tcttccactt tgtgaagatt
      361 gccaattttt cttaccccct gttcttcaag ctaaagtgga gaatttctga attgatgccc
      421 tggcttctat ggctctcggt gtttatttcc ttcagctcca gcatgttctt ctgcaatcat
      481 aaatacactg tgtacaacaa catttctcta agtagcaaca tctgcaactt cacaatggaa
      541 ctctatgtcg ctgaggccaa tgtggtcaat gtggcctttt tattcagttt tggaatcctc
      601 ccacctctga ccatgttcat tgcaacagct actcttctaa ttttttctct caggagacac
      661 accctgcaca tgagaaacgg tgatgctgac tccagaaatc cccgagtaga ggctcataag
      721 caggccatca aggaaaccag ctgctttctc tttctctaca tcttatatgc agctgttctg
      781 tttctgtcca catccaacat agctgatgcc agtctcttct ggagtagtgt tctcagaatc
      841 agtctgccgg tctacccagc tggccactca gttttactga ttcagagcaa ccctggctta
      901 aaaagaacgt ggaagcaact tctgtcccaa atccatctgc acttacaaag tagatactga
//
LOCUS       NM_178144               1527 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 3 (Amigo3),
            mRNA.
ACCESSION   NM_178144
VERSION     NM_178144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   2  (bases 1 to 1527)
  AUTHORS   Ahmed,Z., Douglas,M.R., John,G., Berry,M. and Logan,A.
  TITLE     AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition
            in the acute phase of adult central nervous system injury
  JOURNAL   PLoS One 8 (4), e61878 (2013)
   PUBMED   23613963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY237731.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY237731.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1527
                     /gene="Amigo3"
                     /note="adhesion molecule with Ig like domain 3"
                     /db_xref="GeneID:316003"
                     /db_xref="RGD:631413"
     CDS             1..1527
                     /gene="Amigo3"
                     /EC_number="2.7.7.13"
                     /note="amphoterin-induced protein 3; AMIGO-3; alivin-3;
                     amphoterin induced gene and ORF 3; transmembrane protein
                     AMIGO3"
                     /codon_start=1
                     /product="amphoterin-induced protein 3 precursor"
                     /protein_id="NP_835280.1"
                     /db_xref="GeneID:316003"
                     /db_xref="RGD:631413"
                     /translation="MAWLVLLGLLLCMLGAGSGTSDLEGVLPPDPHNCPNKCVCAADV
                     LSCAGRGLQDLPAALPATAAELDLSHNALKRLHPGWLAPLSRLRALYLGYNKLDVLGR
                     GVFTNASGLRILDLSSNLLRRLRTYDLDGLEELEKLLLFNNRLMHLDLDAFQGLSMLS
                     HLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLGHVSVPELAALPTFLKNRLYLHN
                     NPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLAFKVAESRVRFFEHSRVFKNCSVA
                     AAPGLELPEEELHTHVGQSLRLFCNTTVPAARVAWVSPKNELLVAPGSQDGSIAVLAD
                     GSLAIGRVQEQHAGLFVCLASGPRLHHNQTLEYNVSVHKPRPEPEAFNTGFTTLLGCI
                     VGLVLVLLYLFAPPCRGCCRCCRRACRNRCWPRASSPLQELSAQSSVLSTTPPDAPSR
                     KASVHKHVAFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLMMS
                     "
     sig_peptide     1..57
                     /gene="Amigo3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     58..1524
                     /gene="Amigo3"
                     /product="Amphoterin-induced protein 3.
                     /evidence=ECO:0000255. /id=PRO_0000014515"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1)"
     misc_feature    184..249
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 1"
     misc_feature    <193..>663
                     /gene="Amigo3"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <193..>663
                     /gene="Amigo3"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    193..258
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    193..258
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    256..321
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 2"
     misc_feature    259..330
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    259..330
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    319..321
                     /gene="Amigo3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD5.1); glycosylation site"
     misc_feature    328..393
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 3"
     misc_feature    331..402
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    331..402
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    400..465
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 4"
     misc_feature    403..474
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    403..474
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    472..534
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 5"
     misc_feature    475..552
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    475..552
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    550..621
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     Region: LRR 6"
     misc_feature    553..624
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    553..624
                     /gene="Amigo3"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    814..816
                     /gene="Amigo3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD5.1); glycosylation site"
     misc_feature    835..1065
                     /gene="Amigo3"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    835..1065
                     /gene="Amigo3"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    901..903
                     /gene="Amigo3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD5.1); glycosylation site"
     misc_feature    1084..1086
                     /gene="Amigo3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD5.1); glycosylation site"
     misc_feature    1102..1104
                     /gene="Amigo3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80ZD5.1); glycosylation site"
     misc_feature    1150..1212
                     /gene="Amigo3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80ZD5.1);
                     transmembrane region"
     exon            1..1527
                     /gene="Amigo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctggt tggtgctact gggtctacta ctgtgcatgt tgggggctgg atcaggcact
       61 tcagatttgg agggtgttct gccccctgat ccccacaact gccccaataa atgtgtctgt
      121 gctgccgatg tgttgagctg tgcgggccgt gggttacagg acttgccggc agcactgcct
      181 gccactgctg cagaacttga tttgagccac aatgcactca aacgcctgca cccaggatgg
      241 ctggcgcccc tctcccggct gcgtgccttg tacctaggct acaataagtt ggatgtcctg
      301 ggccgcggtg tgttcactaa cgccagtggg ctgaggatac tcgatctgtc ctctaacctg
      361 ctgaggagac tccgtaccta tgacctggat ggactggagg agctggagaa gttacttctg
      421 ttcaataacc gcctgatgca cttggacctg gatgctttcc agggcctgag catgctcagc
      481 cacctctatc tcagctgcaa cgaactctcc tctttctctt tcaaccacct gcacggcctg
      541 gggttaaccc gcctacgcac tctagacctc tcctccaact ggctgggcca tgtctccgtc
      601 cctgaactgg ctgcactgcc cactttcctc aagaatcggc tctacttgca caacaaccca
      661 ctgccctgcg actgcagcct ctaccacctg ctccggcgct ggcaccagcg gggcctaagt
      721 gctctgcacg actttgaacg tgagtacaca tgcttggcct ttaaggtggc agaatcccga
      781 gtgcgcttct tcgagcacag ccgggtcttc aagaactgct cagtggctgc agctccaggc
      841 ttagagctgc ccgaggaaga gctgcacaca cacgtgggcc agtccctgag gctcttctgc
      901 aacaccacag tgcctgctgc acgagtggcc tgggtttccc cgaaaaacga gctgctggtc
      961 gcgccaggct cccaggatgg cagcattgct gtgttggcgg atggcagctt agccataggc
     1021 agggtgcaag aacagcacgc aggcctcttt gtgtgcctgg caagtgggcc ccgcctgcac
     1081 cacaaccaga cgcttgagta caatgtgagt gtacataagc ctcgccccga gccggaggct
     1141 ttcaacacgg gcttcaccac actgctgggc tgtatcgtgg gcctggtgct ggtgctgctc
     1201 tacctgtttg caccaccctg tcgtggctgc tgtcgctgtt gtcggcgggc ctgccgcaac
     1261 cgttgctggc cccgggcatc cagtccactc caggagctga gtgcacagtc ctcggtgctc
     1321 agcactacac cgccagatgc acccagccgc aaggccagcg tccacaagca tgtggccttc
     1381 ctggagccgg gcaagaaagg cctcaatggc cgtgtgcagc tagcagtagc tgaagacttt
     1441 gatctgtgca accccatggg cttgcaactc aaggctggct ctgagtcagc cagttccaca
     1501 ggctcagagg gtctcatgat gagctag
//
LOCUS       NM_198775               1660 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prolyl 4-hydroxylase subunit alpha 3 (P4ha3),
            mRNA.
ACCESSION   NM_198775 XM_341890
VERSION     NM_198775.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Kukkola,L., Hieta,R., Kivirikko,K.I. and Myllyharju,J.
  TITLE     Identification and characterization of a third human, rat, and
            mouse collagen prolyl 4-hydroxylase isoenzyme
  JOURNAL   J Biol Chem 278 (48), 47685-47693 (2003)
   PUBMED   14500733
  REMARK    GeneRIF: analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its
            expression and catalytic properties
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY313450.1.
            
            On Dec 17, 2003 this sequence version replaced XM_341890.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY313450.1, SRR8487227.71417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1660
                     /gene="P4ha3"
                     /note="prolyl 4-hydroxylase subunit alpha 3"
                     /db_xref="GeneID:361612"
                     /db_xref="RGD:735150"
     exon            1..225
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1660
                     /gene="P4ha3"
                     /EC_number="1.14.11.2"
                     /note="4-PH alpha-3;
                     procollagen-proline,2-oxoglutarate-4-dioxygenase subunit
                     alpha-3; procollagen-proline, 2-oxoglutarate 4-dioxygenase
                     (proline 4-hydroxylase), alpha polypeptide III; collagen
                     prolyl 4-hydroxylase alpha III subunit; prolyl
                     4-hydroxylase, alpha polypeptide III"
                     /codon_start=1
                     /product="prolyl 4-hydroxylase subunit alpha-3 precursor"
                     /protein_id="NP_942070.1"
                     /db_xref="GeneID:361612"
                     /db_xref="RGD:735150"
                     /translation="MGPGARLAALLVLLKLGVGDPAAAAGREDTFSALTSVARALAPE
                     RRLLGTLRRYLRGEEARLRDLTRFYDKVLSLHEDLKIPVVNPLLVFTLIKRLPSDWRN
                     VVHSLEATENIRAPKDGYEKVEQDLPAFEDLEGAARALMRLQDAYMLNVKGLAQGVFQ
                     RVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVSLFRRSYGEW
                     KTEDEASLEDALDYLAFACYQVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLLAE
                     NGHLMAAETAIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYCSYETNSSPYLLL
                     QPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKS
                     AWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSP
                     LYKMKSGNRAATLMIYLSSVEAGGATAFIYGNFSVPVVKNAALFWWNLHRSGEGDDDT
                     LHAGCPVLVGDKWVANKWIHEYGQEFRRPCDTNPED"
     sig_peptide     26..97
                     /gene="P4ha3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     98..1657
                     /gene="P4ha3"
                     /product="Prolyl 4-hydroxylase subunit alpha-3.
                     /id=PRO_0000317768"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6W3E9.1)"
     misc_feature    122..505
                     /gene="P4ha3"
                     /note="Prolyl 4-Hydroxylase alpha-subunit, N-terminal
                     region; Region: P4Ha_N; pfam08336"
                     /db_xref="CDD:462433"
     misc_feature    122..505
                     /gene="P4ha3"
                     /note="Prolyl 4-Hydroxylase alpha-subunit, N-terminal
                     region; Region: P4Ha_N; pfam08336"
                     /db_xref="CDD:462433"
     misc_feature    704..805
                     /gene="P4ha3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6W3E9.1);
                     Region: TPR"
     misc_feature    749..751
                     /gene="P4ha3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6W3E9.1); glycosylation site"
     misc_feature    1091..1609
                     /gene="P4ha3"
                     /note="Prolyl 4-hydroxylase alpha subunit homologues;
                     Region: P4Hc; smart00702"
                     /db_xref="CDD:214780"
     misc_feature    1091..1609
                     /gene="P4ha3"
                     /note="Prolyl 4-hydroxylase alpha subunit homologues;
                     Region: P4Hc; smart00702"
                     /db_xref="CDD:214780"
     misc_feature    1469..1471
                     /gene="P4ha3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6W3E9.1); glycosylation site"
     exon            226..368
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..592
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..742
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..794
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            795..958
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1135
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1200
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1360
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1423
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1492
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1589
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1660
                     /gene="P4ha3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggaggg acgcgcgacc ccgcgatggg cccaggggcg cggctggcgg cgctgctggt
       61 gctgctgaag ctcggggtcg gagaccctgc ggcggccgcg gggcgggagg acacgttctc
      121 cgctctgacc agcgtggcgc gcgccctggc gcccgagcgc cggctgctgg ggacactgag
      181 gcgctacctg cgcggcgagg aggcgcggct gcgcgacctg accagattct atgacaaggt
      241 actttctttg cacgaggact tgaagatccc tgtagtgaat cccctacttg tcttcactct
      301 catcaaacgt ctgccgtctg actggaggaa tgtggtacac agtctggaag ccactgagaa
      361 tatccgagct ccgaaggatg gttatgagaa ggtggagcaa gaccttcctg cctttgagga
      421 cctcgaggga gcagcaaggg ccctgatgcg actgcaggac gcgtacatgc tcaatgtgaa
      481 gggcttggcc cagggcgtct tccagagagt cacgggctcc tccatcactg acctgtacag
      541 tcccaggcag ctcttctctc tcacagcgga tgactgcttc caagttggta aggtggccta
      601 tgacacgggg gattactacc atgccattcc gtggctggag gaagctgtca gtctcttccg
      661 aagatcttac ggagagtgga agacagagga tgaggccagt ctggaagacg ccctggatta
      721 tttggccttt gcctgttacc aggtaggaaa tgtttcgtgt gccctcagcc tctctcgaga
      781 gttccttgtc tacagcccag acaataagag gatggccagg aatgtgttga aatacgaaag
      841 gctcttggct gagaatggtc acctgatggc ggctgagaca gcaattcaga ggcccaacgt
      901 accccacctc cagaccaggg acacctatga ggggctatgc cagaccctgg gctcccagcc
      961 aacacactac caaatcccca gcctctactg ctcctacgag accaattcca gcccctacct
     1021 actgctccag cccgcacgca aggaggtcat ccacctgcgg cccctcgtgg ctctctacca
     1081 tgatttcgtc agtgatgagg aagcccagaa aatccgagag ctcgcagaac cgtggctcca
     1141 gagatcagtg gtggcttcag gggaaaagca gttacaagtg gagtaccgca tcagcaaaag
     1201 tgcctggcta aaggacacgg ttgacccagt gctggtgacc cttgaccgcc gcattgctgc
     1261 cctcacaggc ctcgacatcc agcctccgta cgcagagtat ctccaggtgg tgaactatgg
     1321 aattggaggg cactatgagc ctcacttcga ccatgctacg tcgcccagca gccccctgta
     1381 caagatgaag tccgggaacc gagcggcaac gcttatgata tatctgagct ccgtagaagc
     1441 tggaggagcc acagccttta tctatggcaa cttcagtgtg cctgtggtta agaatgctgc
     1501 actgttttgg tggaacttgc acaggagtgg agagggggat gatgacacac ttcacgctgg
     1561 ctgccctgtg ctggtgggag acaagtgggt ggccaacaag tggatacacg agtatggaca
     1621 ggaattccga agaccctgcg acaccaatcc tgaagactga
//
LOCUS       NM_181770               1407 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 119 (Gpr119), mRNA.
ACCESSION   NM_181770
VERSION     NM_181770.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1407)
  AUTHORS   Kang,Y., Sato,H., Saito,M., Yin,D.X., Park,S.K., Oh,S.B., Bae,Y.C.
            and Toyoda,H.
  TITLE     A role of CB1R in inducing theta;-rhythm coordination between the
            gustatory and gastrointestinal insula
  JOURNAL   Sci Rep 6, 32529 (2016)
   PUBMED   27581068
  REMARK    GeneRIF: The results demonstrate that the neural coordination
            between the the gustatory and gastrointestinal insula is generated
            or suppressed by the opposing activities between CB1R and GPR119.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1407)
  AUTHORS   Park,E.Y., Kim,E.H., Kim,C.Y., Kim,M.H., Choung,J.S., Oh,Y.S.,
            Moon,H.S. and Jun,H.S.
  TITLE     Angelica dahurica Extracts Improve Glucose Tolerance through the
            Activation of GPR119
  JOURNAL   PLoS One 11 (7), e0158796 (2016)
   PUBMED   27391814
  REMARK    GeneRIF: Angelica dahurica extract-treated cells showed significant
            increases in GPR119 activation, intracellular cAMP levels, GLP-1
            levels and glucose-stimulated insulin secretion as compared with
            controls
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1407)
  AUTHORS   Cornall,L.M., Hryciw,D.H., Mathai,M.L. and McAinch,A.J.
  TITLE     Direct activation of the proposed anti-diabetic receptor, GPR119 in
            cardiomyoblasts decreases markers of muscle metabolic activity
  JOURNAL   Mol Cell Endocrinol 402, 72-85 (2015)
   PUBMED   25578601
  REMARK    GeneRIF: Pathways activated in response to GPR119 modulation in
            cardiac muscle cells differ between healthy and metabolically
            dysregulated states.
REFERENCE   4  (bases 1 to 1407)
  AUTHORS   Patel,S., Mace,O.J., Tough,I.R., White,J., Cock,T.A., Warpman
            Berglund,U., Schindler,M. and Cox,H.M.
  TITLE     Gastrointestinal hormonal responses on GPR119 activation in lean
            and diseased rodent models of type 2 diabetes
  JOURNAL   Int J Obes (Lond) 38 (10), 1365-1373 (2014)
   PUBMED   24451185
  REMARK    GeneRIF: Results show that functional GPR119 responses are similar
            in lean and diabetic rodent, and human colon; that GPR119
            stimulation can result in glucose lowering through release of
            intestinal peptide hormones.
REFERENCE   5  (bases 1 to 1407)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 1407)
  AUTHORS   Cornall,L.M., Mathai,M.L., Hryciw,D.H., Simcocks,A.C.,
            O'Brien,P.E., Wentworth,J.M. and McAinch,A.J.
  TITLE     GPR119 regulates genetic markers of fatty acid oxidation in
            cultured skeletal muscle myotubes
  JOURNAL   Mol Cell Endocrinol 365 (1), 108-118 (2013)
   PUBMED   23069642
  REMARK    GeneRIF: Data suggest that GPR119 activation/up-regulation in
            skeletal muscle impairs fatty acid and glucose oxidation;
            diet-induced obesity appears to up-regulate skeletal muscle GPR119.
REFERENCE   7  (bases 1 to 1407)
  AUTHORS   Soga,T., Ohishi,T., Matsui,T., Saito,T., Matsumoto,M., Takasaki,J.,
            Matsumoto,S., Kamohara,M., Hiyama,H., Yoshida,S., Momose,K.,
            Ueda,Y., Matsushime,H., Kobori,M. and Furuichi,K.
  TITLE     Lysophosphatidylcholine enhances glucose-dependent insulin
            secretion via an orphan G-protein-coupled receptor
  JOURNAL   Biochem Biophys Res Commun 326 (4), 744-751 (2005)
   PUBMED   15607732
  REMARK    Erratum:[Biochem Biophys Res Commun. 2005 Apr 1;329(1):417]
REFERENCE   8  (bases 1 to 1407)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY288429.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY288429.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..1407
                     /gene="Gpr119"
                     /note="G protein-coupled receptor 119"
                     /db_xref="GeneID:302813"
                     /db_xref="RGD:727808"
     CDS             1..1407
                     /gene="Gpr119"
                     /codon_start=1
                     /product="glucose-dependent insulinotropic receptor"
                     /protein_id="NP_861435.1"
                     /db_xref="GeneID:302813"
                     /db_xref="RGD:727808"
                     /translation="MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFT
                     LNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFD
                     RYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAV
                     FHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPV
                     NDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNP
                     LIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYT
                     CDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLY
                     TCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTE
                     QTPLKRANMSDPLRTCRG"
     misc_feature    16..870
                     /gene="Gpr119"
                     /note="G protein-coupled receptor 119, also called
                     glucose-dependent insulinotropic receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR119_R_insulinotropic_receptor;
                     cd15104"
                     /db_xref="CDD:320232"
     misc_feature    16..870
                     /gene="Gpr119"
                     /note="G protein-coupled receptor 119, also called
                     glucose-dependent insulinotropic receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR119_R_insulinotropic_receptor;
                     cd15104"
                     /db_xref="CDD:320232"
     misc_feature    19..96
                     /gene="Gpr119"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320232"
     misc_feature    19..96
                     /gene="Gpr119"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320232"
     misc_feature    19..81
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    112..174
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    118..198
                     /gene="Gpr119"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320232"
     misc_feature    118..198
                     /gene="Gpr119"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320232"
     misc_feature    232..324
                     /gene="Gpr119"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320232"
     misc_feature    232..324
                     /gene="Gpr119"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320232"
     misc_feature    order(241..243,253..258,265..270,496..498,505..510,
                     517..519,712..714,721..726,733..735,781..783,793..795,
                     805..807)
                     /gene="Gpr119"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320232"
     misc_feature    order(241..243,253..258,265..270,496..498,505..510,
                     517..519,712..714,721..726,733..735,781..783,793..795,
                     805..807)
                     /gene="Gpr119"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320232"
     misc_feature    244..306
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    358..420
                     /gene="Gpr119"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320232"
     misc_feature    358..420
                     /gene="Gpr119"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320232"
     misc_feature    376..438
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    484..573
                     /gene="Gpr119"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320232"
     misc_feature    484..573
                     /gene="Gpr119"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320232"
     misc_feature    493..555
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    652..744
                     /gene="Gpr119"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320232"
     misc_feature    652..744
                     /gene="Gpr119"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320232"
     misc_feature    679..741
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    772..849
                     /gene="Gpr119"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320232"
     misc_feature    772..849
                     /gene="Gpr119"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320232"
     misc_feature    787..849
                     /gene="Gpr119"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQN8.1);
                     transmembrane region"
     misc_feature    1036..>1359
                     /gene="Gpr119"
                     /note="N-terminal domain of Kruppel-like factor 18;
                     Region: KLF18_N; cd21575"
                     /db_xref="CDD:410566"
     misc_feature    1036..>1359
                     /gene="Gpr119"
                     /note="N-terminal domain of Kruppel-like factor 18;
                     Region: KLF18_N; cd21575"
                     /db_xref="CDD:410566"
     exon            1..888
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
     exon            889..966
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1324
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1407
                     /gene="Gpr119"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtcat ctttctcatt tggagtgatc cttgctgtcc tgaccatcct tatcattgct
       61 gttaatgcgc tggtggttgt ggctatgctg ctatcaatct acaagaatga tggtgttggc
      121 ctttgcttca ccttaaatct ggccgtggct gataccttga ttggcgtggc tatttctggg
      181 ctagttacag accagctctc cagctctgct cagcacacac agaagacctt gtgtagcctt
      241 cggatggcat tcgtcacttc ttctgcagcc gcctctgtcc tcacggtcat gctgattgcc
      301 tttgacaggt acctggccat taagcagccc ctccgttact tccagatcat gaatgggctt
      361 gtagccggag gatgcattgc agggctgtgg ttgatatctt accttatcgg cttcctccca
      421 cttggagtct ccatattcca gcagaccacc taccatgggc cctgcacctt ctttgctgtg
      481 tttcacccaa ggtttgtgct gaccctctcc tgtgctggct tcttcccagc tgtgctcctc
      541 tttgtcttct tctactgtga catgctcaag attgcctctg tgcacagcca gcacatccgg
      601 aagatggaac atgcaggagc catggttgga gcttgccggc ccccacggcc tgtcaatgac
      661 ttcaaggctg tccggactgt atctgtcctt attgggagct tcaccctgtc ctggtctccg
      721 tttctcatca ctagcattgt gcaggtggcc tgccacaaat gctgcctcta ccaagtgctg
      781 gaaaaatacc tctggctcct tggagttggc aactccctgc tcaacccact catctatgcc
      841 tattggcaga gggaggttcg gcagcagctc tgccacatgg ccctggggct acttgctgat
      901 ggcagtacac aaccccaaat tgagacactg aaagggaagg aagagagaaa gaaggtagga
      961 agaaagacgc tgtacacatg tgatgcacag acgctgtaca catgtgatgc acagacgctg
     1021 tacacatgtg atgcacagac gctgtacaca tgtgatgcat gtgatacaca gacactgtac
     1081 acatgtgatg cacagacgct gtacacatgt gatgcacaga cgctgtacac atgtgatgca
     1141 cagacgctgt acacatgtga tgcacagacg ctgtacacat gtgatgcaca gacactgtac
     1201 acatgtgata cacagacgct gtacacatgt gatgcacaga cgctgtacac atgtgatgca
     1261 cagacgctgt acacatgtga tgcacagacg ctgtacacat gtgatgcaca gacgctgtac
     1321 acatcaagtt tggtaactgg ccaaactgag cagacaccac tgaaacgagc aaacatgagt
     1381 gatcctctga ggacatgcag gggataa
//
LOCUS       NM_181433               1827 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus otopetrin 1 (Otop1), mRNA.
ACCESSION   NM_181433
VERSION     NM_181433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Tu,Y.H., Cooper,A.J., Teng,B., Chang,R.B., Artiga,D.J.,
            Turner,H.N., Mulhall,E.M., Ye,W., Smith,A.D. and Liman,E.R.
  TITLE     An evolutionarily conserved gene family encodes proton-selective
            ion channels
  JOURNAL   Science 359 (6379), 1047-1050 (2018)
   PUBMED   29371428
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Wang,G.X., Cho,K.W., Uhm,M., Hu,C.R., Li,S., Cozacov,Z., Xu,A.E.,
            Cheng,J.X., Saltiel,A.R., Lumeng,C.N. and Lin,J.D.
  TITLE     Otopetrin 1 protects mice from obesity-associated metabolic
            dysfunction through attenuating adipose tissue inflammation
  JOURNAL   Diabetes 63 (4), 1340-1352 (2014)
   PUBMED   24379350
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK000651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1827
                     /gene="Otop1"
                     /note="otopetrin 1"
                     /db_xref="GeneID:305427"
                     /db_xref="RGD:631389"
     exon            1..421
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1827
                     /gene="Otop1"
                     /codon_start=1
                     /product="proton channel OTOP1"
                     /protein_id="NP_852098.1"
                     /db_xref="GeneID:305427"
                     /db_xref="RGD:631389"
                     /translation="MPGDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASG
                     PRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQL
                     LWMLWYVGRSYMQRRLIRPKDTHAGARWLRGSITLFAFITIVLGCLKVAYFIGFSECL
                     SATEGVFPVTHAVHTLLQVYFLWGHAKDIIMSFKTLERFGVIHSVFTNLLLWANSVLN
                     ESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPALCSALSHGIYYLYPFNIEYQ
                     ILASTMLYVLWKNIGRRVDSSRHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHI
                     GRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDADLL
                     VATASGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLEPE
                     GVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEAD
                     WEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVF
                     GFEPWIIVVNLAMPFSIFYRMHAAAALFEVYCKI"
     misc_feature    25..174
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    193..258
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    283..354
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    409..477
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    415..1782
                     /gene="Otop1"
                     /note="Region: Otopetrin; pfam03189"
                     /db_xref="CDD:460840"
     misc_feature    415..1782
                     /gene="Otop1"
                     /note="Region: Otopetrin; pfam03189"
                     /db_xref="CDD:460840"
     misc_feature    508..582
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    607..687
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    811..888
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    952..1020
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1051..1128
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1183..1257
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1288..1350
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1621..1677
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1732..1803
                     /gene="Otop1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7M734.1);
                     transmembrane region"
     misc_feature    1774..1812
                     /gene="Otop1"
                     /note="consensus F-Y-R-[FM]-H-[SA]-X3[LF]-X-E-[VI];
                     Region: putative FYR-box"
     exon            422..558
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..617
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..748
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1656
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1827
                     /gene="Otop1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcctggg gaccagactg gaagatgcct ggggaccggg gcgcactatc ttctcccgca
       61 gcatcatcag gctccccgag tgccgcgccg tcggggatcg ccgcatgccc tccgcccccg
      121 tctcccctag cccgggcgtc tccacaagct tccggtcccc gacgcggtgc cagcgtcccg
      181 cagaagctgg cggagactct gagcagccag tatggactga acgtgttcgt ggcggggctt
      241 cttttcctgc tggcctgggc ggtgcacgcg acgggtgtgg gcaagagcga cctgttgtgc
      301 gtattaaccg cactcatgct gctgcagctg ctctggatgc tgtggtacgt gggtcgcagc
      361 tacatgcagc gccgcctcat ccgccccaag gacacgcacg cgggtgcgcg ctggctccgc
      421 ggaagcatca cattgttcgc attcatcacc atcgtcctgg ggtgcctgaa agtcgcatac
      481 ttcattggat tctcagagtg cttgtcagct acagagggag ttttcccagt cacccatgca
      541 gtgcatacat tgttgcaggt ctattttctc tggggccacg ctaaagatat tatcatgtct
      601 ttcaaaacac tggaaaggtt tggggtgatc cattcagtgt tcacaaacct gctgctgtgg
      661 gccaacagcg tcctgaatga gtcaaaacac cagctgaatg aacacaagga acggctgatc
      721 actctgggct tcggcaacat caccatagtt ttggatgacc acacaccaca gtgtaactgc
      781 acaccgcctg ccctctgctc tgccctctcc cacgggattt actatctgta ccccttcaac
      841 attgagtacc agatcctggc ctcgaccatg ctctatgtgc tgtggaagaa cattgggcgc
      901 agggtggaca gctcccggca ccagaagatg cagtgcagat tcgacggggt cctggtgggc
      961 tcagtgctgg gcctgacagt gctggctgcc accatcgcgg tggttgtggt gtacatgatc
     1021 catatcgggc gctccaagtc caagagtgag tcggctctta tcatgttcta tttgtatgcg
     1081 atcacggtgc tgctgctcat gggggctgcg gggctggtag gaagctggat ttacagggtg
     1141 gatgagaagt ctctggatga gtcaaagaac ccagcccgca agctggatgc tgacctcttg
     1201 gtggccactg cctcgggttc ctggctcctc tcctggggtt ccattttggc catcgcctgc
     1261 gctgagaccc gcccaccgta cacctggtac aacctcccct actctgtcct ggtgatcgtg
     1321 gagaagtacg tccagaacat tttcatcatt gagtcggtgc acctcgagcc tgagggggtc
     1381 cccgaggatg tgcgcactct gcgtgtggtc accgtctgca gtggggaggc tgctgcactg
     1441 gctgcatcga gtctcgggag ccaggggacg gcccaggatg ggtcacctgc tgtcaatggg
     1501 aatctgcatc tgcagcagag gtgtgagaaa gaggaccagg aggctgactg ggaaggagct
     1561 acggggacaa cccgatgtct ggacttcctt cagggaggca tgaagaggag gctgctcaga
     1621 aacatcacag cctttctgtt cctttgcaac atctcgcttt ggattccccc tgcctttggc
     1681 tgccgtcccg agtatgacaa cggactggag gaaattgtct ttggctttga accctggata
     1741 attgtggtca acctggccat gcccttctcc attttctaca ggatgcacgc agctgccgcc
     1801 ctctttgagg tctattgtaa aatctag
//
LOCUS       NM_023994                900 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 118 (Tas2r118),
            mRNA.
ACCESSION   NM_023994
VERSION     NM_023994.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Behrens,M., Bartelt,J., Reichling,C., Winnig,M., Kuhn,C. and
            Meyerhof,W.
  TITLE     Members of RTP and REEP gene families influence functional bitter
            taste receptor expression
  JOURNAL   J Biol Chem 281 (29), 20650-20659 (2006)
   PUBMED   16720576
REFERENCE   3  (bases 1 to 900)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   4  (bases 1 to 900)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   5  (bases 1 to 900)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   6  (bases 1 to 900)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 900)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   8  (bases 1 to 900)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227141.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227141.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..900
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="taste receptor, type 2, member 118"
                     /db_xref="GeneID:78980"
                     /db_xref="RGD:620735"
     CDS             1..900
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="T2R16; T2R18"
                     /codon_start=1
                     /product="taste receptor type 2 member 16"
                     /protein_id="NP_076484.1"
                     /db_xref="GeneID:78980"
                     /db_xref="RGD:620735"
                     /translation="MVPTQVTIFSIIMYVLESLVIIVQSCTTVAVLFREWMHFQRLSP
                     VEIILISLGISHFCLQWTSMLYNFGTYSRPVLLFWKVSVVWEFMNVLTFWLTSLLAVL
                     YCVKVSSFSHPVFLWLRLKILKLVLWLLLGALIASCLSIIPSVVKYHIQMELLTLDHL
                     PKNSSLILRLQMFEWYFSNPFKMIGFGVPFLVFLISIILLTVSLVQHWGQMKHYSSSS
                     SSLRAQCTVLKSLATFFIFFTSYFLTIVVSFIGTVFDKKSWFWVCEAVIYGLVCIHFT
                     SLMMSNPTLKKALRLQFWSPESS"
     misc_feature    16..78
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    22..870
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..870
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    28..102
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    28..102
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    133..195
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    136..201
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    136..201
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    235..303
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    235..303
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    247..309
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    376..438
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    382..432
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    382..432
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    487..489
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKU0.1); glycosylation site"
     misc_feature    523..594
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    523..594
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    550..612
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    670..738
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    670..738
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    700..762
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     misc_feature    769..846
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    769..846
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    775..837
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKU0.1);
                     transmembrane region"
     exon            1..900
                     /gene="Tas2r118"
                     /gene_synonym="T2R3; Tas2r16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgccaa cccaagtcac catcttctct atcatcatgt atgtgcttga gtccttagtc
       61 ataattgtgc aaagttgcac aacggttgca gtgctgttca gagagtggat gcactttcaa
      121 agactgtcgc cggtggaaat aattctcatc agcctgggca tttcacattt ctgtctacag
      181 tggacatcga tgctgtacaa ctttggtacc tactctaggc ctgtcctttt attttggaag
      241 gtatcggtcg tctgggagtt catgaacgtt ttgacattct ggctaaccag tttgcttgct
      301 gtcctctact gtgtcaaggt ctcttccttc tctcaccccg tcttcctctg gctgaggttg
      361 aaaattttga aactggttct ctggttgcta ttgggcgctc tgatagcttc ttgtttgtca
      421 atcatccctt ctgttgttaa atatcatatc cagatggaat tactcaccct agatcattta
      481 cccaaaaaca gttctttgat tctaagactg caaatgttcg agtggtattt ttctaatcct
      541 ttcaaaatga ttgggtttgg cgttcctttc ctcgtgttcc tgatttctat catcttactc
      601 acagtctcgc tggtccagca ttgggggcag atgaaacact acagcagcag cagctccagc
      661 ctgagagctc agtgcactgt tctgaagtct cttgccacct tcttcatctt cttcacatcc
      721 tattttctga ctatagtcgt ctcctttatt ggcaccgtgt ttgataagaa gtcatggttc
      781 tgggtctgcg aagctgtcat ctatggttta gtctgtattc acttcacttc cctgatgatg
      841 agcaacccta cactgaaaaa agcactcagg ttgcagttct ggagcccaga gtcttcctaa
//
LOCUS       NM_001166679             975 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 116 (Tas2r116),
            mRNA.
ACCESSION   NM_001166679
VERSION     NM_001166679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 975)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY362752.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..975
                     /gene="Tas2r116"
                     /note="taste receptor, type 2, member 116"
                     /db_xref="GeneID:100310877"
                     /db_xref="RGD:2314261"
     CDS             1..975
                     /gene="Tas2r116"
                     /note="T2R33; T2R116; taste receptor type 2 member 33"
                     /codon_start=1
                     /product="taste receptor type 2 member 116"
                     /protein_id="NP_001160151.1"
                     /db_xref="GeneID:100310877"
                     /db_xref="RGD:2314261"
                     /translation="MNGVLYITFTVILSVEVIIGNFGNGIIALVNIMDLAKRRKISSV
                     DQILTALAISRIVLLWLVLVSWWLSMFYPGQWMTEGIDVIVHNVWTTLNQISLWLATS
                     FSVFCFLKVANFSNTIFFYLKIRVKKVMTGTLIMFLLLLGLNIIVINASKTILIPEYK
                     VNMSNSLNLKNTQISMLFPFANTLFGFIPFAVSLVTFLLLFFSLWKHQRKMHHGAQGC
                     RDSSTKAHIRVLQTLIASILLYFVFFLSLVVKVWISLFLERMLLLLITQAAKIAFPSL
                     HPWVLILGNAKLRKASLSALQWLRCRHKDEHRRVQRPEVHSCGSSCMP"
     misc_feature    7..69
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    22..888
                     /gene="Tas2r116"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    22..888
                     /gene="Tas2r116"
                     /note="mammalian taste receptor 2, subtype 14, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R14-like; cd15019"
                     /db_xref="CDD:320147"
     misc_feature    22..99
                     /gene="Tas2r116"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    22..99
                     /gene="Tas2r116"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320147"
     misc_feature    133..207
                     /gene="Tas2r116"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    133..207
                     /gene="Tas2r116"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320147"
     misc_feature    166..228
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    247..315
                     /gene="Tas2r116"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    247..315
                     /gene="Tas2r116"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320147"
     misc_feature    283..345
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    385..447
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    394..444
                     /gene="Tas2r116"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    394..444
                     /gene="Tas2r116"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320147"
     misc_feature    484..486
                     /gene="Tas2r116"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q67ER8.1); glycosylation site"
     misc_feature    523..594
                     /gene="Tas2r116"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    523..594
                     /gene="Tas2r116"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320147"
     misc_feature    550..612
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    667..744
                     /gene="Tas2r116"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    667..744
                     /gene="Tas2r116"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320147"
     misc_feature    709..771
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     misc_feature    778..855
                     /gene="Tas2r116"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    778..855
                     /gene="Tas2r116"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320147"
     misc_feature    784..846
                     /gene="Tas2r116"
                     /note="propagated from UniProtKB/Swiss-Prot (Q67ER8.1);
                     transmembrane region"
     exon            1..975
                     /gene="Tas2r116"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatggtg tcctatacat cacatttaca gtcattctga gtgtggaagt tataattggc
       61 aactttggca atggaatcat agcactggtg aacatcatgg acttggctaa gagaagaaaa
      121 atctcttcag tggatcagat ccttactgcc ctggccattt ctagaattgt gcttctgtgg
      181 ttagtattag tgagttggtg gctatctatg ttctacccag gacaatggat gactgaagga
      241 atagatgtca tagtacataa tgtatggaca acattgaacc agattagtct ctggcttgct
      301 acaagtttca gcgtcttttg tttcctcaag gtagcaaatt tttccaacac tattttcttt
      361 tatttaaaga tcagagttaa aaaagtaatg acagggacat tgataatgtt tttgcttctc
      421 ttgggcttaa atattatagt tattaatgca tctaagacca ttctaatccc tgaatacaaa
      481 gtaaatatgt caaacagttt gaatttgaag aacacacaga tttctatgct gtttccattt
      541 gccaacacct tgtttgggtt catacctttt gctgtgtctc tggtcacctt cctcctgcta
      601 ttcttctccc tgtggaagca tcagaggaag atgcaccacg gtgcccaagg atgcagagat
      661 tctagcacca aggcccacat cagagtcttg cagacactga ttgcctccat cctcctgtat
      721 ttcgttttct ttctgtctct tgttgtcaag gtttggattt ctcttttttt ggagagaatg
      781 cttttgcttt tgattacaca ggctgcaaaa attgcgtttc cctcactgca cccctgggtc
      841 ctgatcctgg gcaatgctaa actcagaaag gcttctctct ctgcactcca gtggctgagg
      901 tgcaggcaca aggatgaaca ccgtagagtg cagagacctg aggttcattc atgtggatca
      961 tcttgcatgc cttag
//
LOCUS       NM_022636               1011 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ventral anterior homeobox 1 (Vax1), mRNA.
ACCESSION   NM_022636
VERSION     NM_022636.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1011)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   2  (bases 1 to 1011)
  AUTHORS   Kim,J.W. and Lemke,G.
  TITLE     Hedgehog-regulated localization of Vax2 controls eye development
  JOURNAL   Genes Dev 20 (20), 2833-2847 (2006)
   PUBMED   17043310
REFERENCE   3  (bases 1 to 1011)
  AUTHORS   Mui,S.H., Kim,J.W., Lemke,G. and Bertuzzi,S.
  TITLE     Vax genes ventralize the embryonic eye
  JOURNAL   Genes Dev 19 (10), 1249-1259 (2005)
   PUBMED   15905411
REFERENCE   4  (bases 1 to 1011)
  AUTHORS   Soria,J.M., Taglialatela,P., Gil-Perotin,S., Galli,R., Gritti,A.,
            Verdugo,J.M. and Bertuzzi,S.
  TITLE     Defective postnatal neurogenesis and disorganization of the rostral
            migratory stream in absence of the Vax1 homeobox gene
  JOURNAL   J Neurosci 24 (49), 11171-11181 (2004)
   PUBMED   15590934
REFERENCE   5  (bases 1 to 1011)
  AUTHORS   Taglialatela,P., Soria,J.M., Caironi,V., Moiana,A. and Bertuzzi,S.
  TITLE     Compromised generation of GABAergic interneurons in the brains of
            Vax1-/- mice
  JOURNAL   Development 131 (17), 4239-4249 (2004)
   PUBMED   15280216
REFERENCE   6  (bases 1 to 1011)
  AUTHORS   Hallonet,M., Hollemann,T., Pieler,T. and Gruss,P.
  TITLE     Vax1, a novel homeobox-containing gene, directs development of the
            basal forebrain and visual system
  JOURNAL   Genes Dev 13 (23), 3106-3114 (1999)
   PUBMED   10601036
REFERENCE   7  (bases 1 to 1011)
  AUTHORS   Bertuzzi,S., Hindges,R., Mui,S.H., O'Leary,D.D. and Lemke,G.
  TITLE     The homeodomain protein vax1 is required for axon guidance and
            major tract formation in the developing forebrain
  JOURNAL   Genes Dev 13 (23), 3092-3105 (1999)
   PUBMED   10601035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF113515.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF113515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1011
                     /gene="Vax1"
                     /note="ventral anterior homeobox 1"
                     /db_xref="GeneID:64571"
                     /db_xref="RGD:621132"
     CDS             1..1011
                     /gene="Vax1"
                     /note="ventral anterior homeobox containing gene 1"
                     /codon_start=1
                     /product="ventral anterior homeobox 1"
                     /protein_id="NP_072158.1"
                     /db_xref="GeneID:64571"
                     /db_xref="RGD:621132"
                     /translation="MFGKTDKMDVRCHSDTEAARVSKNAHKESREIKGAEGSLPAAFL
                     KEPQGAFSASGASEDCNKSKSNSSADPDYCRRILVRDAKGSIREIILPKGLDLDRPKR
                     TRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQG
                     KDSELRSVVSETAATCSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALG
                     AGAAAGSAAAAAAAATAPGPAGAASQHPPAVGGAPGPGPAGPGGLHAGAPTASHGLFS
                     LPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSARYLSSSAFEPYSRTNNKEGAEKKA
                     LD"
     misc_feature    1..117
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JM00.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    148..207
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JM00.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    214..297
                     /gene="Vax1"
                     /note="Region: vax upstream domain"
     misc_feature    298..477
                     /gene="Vax1"
                     /note="Region: homeobox"
     misc_feature    301..471
                     /gene="Vax1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    301..471
                     /gene="Vax1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    532..567
                     /gene="Vax1"
                     /note="Region: vax downstream domain"
     misc_feature    706..801
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JM00.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    943..969
                     /gene="Vax1"
                     /note="Region: vax terminal domain"
     exon            1..241
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..429
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1011
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcggga aaacagacaa aatggacgtc cggtgccact cggacaccga ggccgccagg
       61 gtatcgaaga acgcgcacaa ggagagccga gagatcaagg gcgccgaggg gagccttccg
      121 gctgccttcc tcaaggagcc gcagggcgcc ttttcggcgt ctggcgcttc cgaagattgt
      181 aacaaaagta aatccaattc ctcagcagac ccagattact gccgccggat cctagtccga
      241 gatgccaagg ggtctatccg agaaatcatc ctgcccaagg gcttggacct ggaccggccc
      301 aagaggacac gcacgtcctt caccgcggag cagctctaca gactggagat ggagttccag
      361 cgttgccaat atgtagtggg ccgggagaga accgagctgg ctcggcagct caatctttct
      421 gaaacccagg tgaaggtctg gttccagaat cggcggacca agcagaagaa ggaccagggt
      481 aaagactcgg agctgcgctc ggtggtgtcg gagaccgccg ccacgtgcag cgtgctgcgg
      541 ctgttggagc aaggccgcct gttgtcgcct cccgggctgc ccgccttgct gccgccctgt
      601 gctacaggcg ctctgggctc cgcgttgcgc gggcccagcc tcccggccct gggtgcaggc
      661 gctgctgcgg gctccgccgc tgctgccgcc gccgccgcca ctgccccggg tccggccggc
      721 gcggcgtccc agcatccgcc agccgtgggc ggcgctcccg gccccgggcc tgcagggccc
      781 gggggactgc acgcgggagc tccgacagcc agccacggtc tcttcagcct gccggtgccg
      841 tcgctgctag gctctgtcgc cagccgcctg tcctccgccc cgttgacgat ggctggttcg
      901 ctagccggga atttgcaaga actctcagcc cgttacctga gctcctcggc cttcgagcct
      961 tactcccgga ccaacaataa agaaggggcc gagaaaaaag cgctggactg a
//
LOCUS       NM_001109168            1047 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus calcium homeostasis modulator 1 (Calhm1), mRNA.
ACCESSION   NM_001109168 XM_001059715 XM_574681
VERSION     NM_001109168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Puebla,M., Munoz,M.F., Lillo,M.A., Contreras,J.E. and Figueroa,X.F.
  TITLE     Control of astrocytic Ca2+ signaling by nitric oxide-dependent
            S-nitrosylation of Ca2+ homeostasis modulator 1 channels
  JOURNAL   Biol Res 57 (1), 19 (2024)
   PUBMED   38689353
  REMARK    GeneRIF: Control of astrocytic Ca[2+] signaling by nitric
            oxide-dependent S-nitrosylation of Ca[2+] homeostasis modulator 1
            channels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Bigiani,A.
  TITLE     Calcium Homeostasis Modulator 1-Like Currents in Rat Fungiform
            Taste Cells Expressing Amiloride-Sensitive Sodium Currents
  JOURNAL   Chem Senses 42 (4), 343-359 (2017)
   PUBMED   28334404
  REMARK    GeneRIF: findings indicate that communication between
            salt-detecting cells and nerve endings might involve ATP release by
            CALMH1 channels.
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Liu,W., Ao,Q., Guo,Q., He,W., Peng,L., Jiang,J. and Hu,X.
  TITLE     miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful
            Diabetic Neuropathy Rats
  JOURNAL   Mol Neurobiol 54 (2), 922-929 (2017)
   PUBMED   26781424
  REMARK    GeneRIF: CALHM1 was increased in painful diabetic neuropathy
            compared with controls.
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Taruno,A., Vingtdeux,V., Ohmoto,M., Ma,Z., Dvoryanchikov,G., Li,A.,
            Adrien,L., Zhao,H., Leung,S., Abernethy,M., Koppel,J., Davies,P.,
            Civan,M.M., Chaudhari,N., Matsumoto,I., Hellekant,G., Tordoff,M.G.,
            Marambaud,P. and Foskett,J.K.
  TITLE     CALHM1 ion channel mediates purinergic neurotransmission of sweet,
            bitter and umami tastes
  JOURNAL   Nature 495 (7440), 223-226 (2013)
   PUBMED   23467090
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Siebert,A.P., Ma,Z., Grevet,J.D., Demuro,A., Parker,I. and
            Foskett,J.K.
  TITLE     Structural and functional similarities of calcium homeostasis
            modulator 1 (CALHM1) ion channel with connexins, pannexins, and
            innexins
  JOURNAL   J Biol Chem 288 (9), 6140-6153 (2013)
   PUBMED   23300080
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Ma,Z., Siebert,A.P., Cheung,K.H., Lee,R.J., Johnson,B., Cohen,A.S.,
            Vingtdeux,V., Marambaud,P. and Foskett,J.K.
  TITLE     Calcium homeostasis modulator 1 (CALHM1) is the pore-forming
            subunit of an ion channel that mediates extracellular Ca2+
            regulation of neuronal excitability
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), E1963-E1971 (2012)
   PUBMED   22711817
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Dreses-Werringloer,U., Lambert,J.C., Vingtdeux,V., Zhao,H.,
            Vais,H., Siebert,A., Jain,A., Koppel,J., Rovelet-Lecrux,A.,
            Hannequin,D., Pasquier,F., Galimberti,D., Scarpini,E., Mann,D.,
            Lendon,C., Campion,D., Amouyel,P., Davies,P., Foskett,J.K.,
            Campagne,F. and Marambaud,P.
  TITLE     A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels,
            and Alzheimer's disease risk
  JOURNAL   Cell 133 (7), 1149-1161 (2008)
   PUBMED   18585350
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574681.2, XM_001059715.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="calcium homeostasis modulator 1"
                     /db_xref="GeneID:499367"
                     /db_xref="RGD:1564891"
     CDS             1..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="family with sequence similarity 26, member C"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 1"
                     /protein_id="NP_001102638.1"
                     /db_xref="GeneID:499367"
                     /db_xref="RGD:1564891"
                     /translation="MDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCL
                     PGYNVVYSMGILLTPPLVLFLLGLVMNNNISMLAEEWKRPLGRRAKDPAVLRYMFCSM
                     AQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVATLGNGSLVPGLPAPELARLLARVPC
                     PEIYDGNWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQVAFLKSKY
                     WSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGVLATASARTTAT
                     EAIQSPSDRTEEEREKLRGITDQGSMNRLLTSWHKCKPPLRLGQEAPLMSNGWAGSEP
                     RPPRKEVATYFSKV"
     misc_feature    4..762
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="Calcium homeostasis modulator; Region: Ca_hom_mod;
                     pfam14798"
                     /db_xref="CDD:464320"
     misc_feature    4..762
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /note="Calcium homeostasis modulator; Region: Ca_hom_mod;
                     pfam14798"
                     /db_xref="CDD:464320"
     exon            1..552
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1047
                     /gene="Calhm1"
                     /gene_synonym="Fam26c; RGD1564891"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacaagt ttcggatgat cttccagttc ttgcagtcca accaagagtc cttcatgaac
       61 ggcatctgcg gcatcatggc gctggccagt gcccagatgt actctgcctt tgacttcaac
      121 tgcccctgct tgcccggcta caatgtggtc tacagcatgg gcatactgct gacgcctccc
      181 ctggtgctct tcctgcttgg cctggtcatg aacaacaaca tatccatgct agctgaagag
      241 tggaaacgcc ccctggggcg ccgggccaag gaccctgccg tgctacgcta catgttctgt
      301 tccatggccc agcgagcgct catcgcccct gtggtctggg tggcagtcac actgctggac
      361 ggcaagtgtt tcctctgtgc tttctgcaca gccgtgccgg tggccacgct aggcaatggg
      421 agcctggtgc cgggcctgcc tgctccagaa cttgctcgcc tgctggctcg tgtaccttgc
      481 cctgaaatct acgatgggaa ctggctgctg gcccgagagg tggccgtgcg ctatttgcgc
      541 tgcatctctc aggcgctggg ctggtccttc gtgctgctga ccacattact ggcatttgta
      601 gtgcgctccg tgcggccctg cttcacgcag gttgcctttc tcaagagcaa gtactggtcc
      661 cactacattg acattgagcg taagctcttc gatgagactt gcacggagca tgccaaagcc
      721 tttgctaagg tatgtatcca gcagttcttc gaagccatga accatgacct ggagctgggt
      781 catacccacg gagtactggc cacagcttcg gccagaacta cagccacaga ggccatccaa
      841 agtccctccg acaggaccga agaagagagg gagaagctgc gaggcatcac tgaccaaggc
      901 agcatgaaca ggctactcac aagctggcac aaatgcaaac cacccttgag gctgggccag
      961 gaggcaccac tgatgagcaa tggctgggct gggagcgagc cccggcctcc acgcaaggaa
     1021 gtggccacct acttcagcaa agtgtga
//
LOCUS       NM_001009969             591 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Spetex-2H protein (Spetex2h), mRNA.
ACCESSION   NM_001009969 XM_341283
VERSION     NM_001009969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Iwamoto,Y., Kaneko,T., Ichinose,J., Mori,T., Shibata,Y.,
            Toshimori,K. and Iida,H.
  TITLE     Molecular cloning of rat Spetex2 family genes mapped on chromosome
            15p16, encoding a 23-kilodalton protein associated with the plasma
            membranes of haploid spermatids
  JOURNAL   Biol Reprod 72 (2), 284-292 (2005)
   PUBMED   15371276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB180083.1.
            
            On Jan 22, 2005 this sequence version replaced XM_341283.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180083.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15"
     gene            1..591
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /note="Spetex-2H protein"
                     /db_xref="GeneID:361008"
                     /db_xref="RGD:1359560"
     CDS             1..591
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /codon_start=1
                     /product="Spetex-2H protein"
                     /protein_id="NP_001009969.1"
                     /db_xref="GeneID:361008"
                     /db_xref="RGD:1359560"
                     /translation="MFHQLLKLVQKERGDQGETRLRQKKAGLLSWFIRKASSENFISN
                     HEKRIKKLEELKLEIQKCKIERDELSRILDLYVNDGLNYRLSVELPMLKSQHEMRTMD
                     MHKMTNWISDAMEKYKELTQENNSYHIRNFHLLNECNELKKNVRILMNENRKLLVEQT
                     ELQASCEIRMGKRFCEEASKTIYTADIESLCPVTFE"
     misc_feature    100..342
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    100..342
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            1..91
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /inference="alignment:Splign:2.1.0"
     exon            92..251
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /inference="alignment:Splign:2.1.0"
     exon            252..383
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /inference="alignment:Splign:2.1.0"
     exon            384..591
                     /gene="Spetex2h"
                     /gene_synonym="Spergen-2H; Spetex-2H"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttcacc agctgctcaa gctagttcag aaggagaggg gagaccaagg agagaccaga
       61 ctgaggcaga agaaagctgg cctcctgtct tggtttattc ggaaggcatc atcagaaaat
      121 ttcatcagta accatgaaaa gcgtataaag aaattggagg aactaaaact tgaaatccag
      181 aagtgtaaaa tcgagcggga tgaactttct cgaatcctgg acctttatgt caatgatggt
      241 ttgaactaca ggctgagtgt tgaattgcca atgcttaaat cccaacatga gatgagaacg
      301 atggatatgc ataagatgac caactggata agtgatgcca tggagaagta caaggagctc
      361 acacaagaga ataattccta ccacatcaga aacttccacc tcctgaatga atgcaatgaa
      421 ttgaagaaga atgtaaggat tttgatgaat gagaacagaa aactgctggt ggagcagact
      481 gaactgcaag catcctgtga gataagaatg ggaaagaggt tctgtgagga ggccagcaag
      541 accatctaca ccgcagatat tgaatccttg tgtcctgtta cttttgagta a
//
LOCUS       NM_001008850            1026 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, locus M1, gene 4 (RT1-M1-4), mRNA.
ACCESSION   NM_001008850 XM_227951
VERSION     NM_001008850.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1026)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883051.1.
            
            On Jan 5, 2005 this sequence version replaced XM_227951.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16418971
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1026
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="RT1 class I, locus M1, gene 4"
                     /db_xref="GeneID:294213"
                     /db_xref="RGD:1359375"
     CDS             1..1026
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="histocompatibility 2, M region locus 11"
                     /codon_start=1
                     /product="RT1 class I, locus M1, gene 4 precursor"
                     /protein_id="NP_001008850.1"
                     /db_xref="GeneID:294213"
                     /db_xref="RGD:1359375"
                     /translation="MKTFVTEALLLLLLAVLALASHPEGSHLFGLFQTLLTRPGHSEP
                     LFISAGFMDNIQFERFNNRSDFPGMEHCAPWIDHRSPEYWKEHTQRALKDIRFMRQAL
                     KLMIHTYNYSATGYHTIQRRIGCHVLPRGYFSHGFLELAFNGQDYIMLNEDLRTWTTV
                     GKAAEILRKEWEKHSFAQAMKIYLEVSCVDSFLTELAYGKEILLRIDPPKVQVIRKVR
                     LNRKITLMCWALSFYPPEITLTWQRDGCNQMQDMEVVETRPAGDGTFQKWAAVVVSSG
                     EEQRYTCHVNHKGLPEVITMRWEPPEPIIPITTIVIAVVLGALVVGAVMTFLIWKMTR
                     GKERAWF"
     sig_peptide     1..60
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    73..609
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    73..609
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    619..894
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    619..894
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    622..645
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    622..645
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    667..696
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    667..696
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    order(676..678,682..684,763..768,772..780,796..798,
                     802..804)
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(676..678,682..684,763..768,772..780,796..798,
                     802..804)
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(697..705,787..789,862..864)
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    order(697..705,787..789,862..864)
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    709..726
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    709..726
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    733..744
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    733..744
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    754..780
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    754..780
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    787..819
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    787..819
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    838..861
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    838..861
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    880..891
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    880..891
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     exon            1..73
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="alignment:Splign:2.1.0"
     exon            74..343
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="alignment:Splign:2.1.0"
     exon            344..619
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="alignment:Splign:2.1.0"
     exon            620..895
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1026
                     /gene="RT1-M1-4"
                     /gene_synonym="H2-M11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagacct ttgttactga ggctctcctg ctgctgctcc tagcagtgct ggccctggcc
       61 agccatccag aaggttcaca tctttttggc cttttccaaa ctctcttgac ccggcctgga
      121 cattctgagc ccctatttat cagtgctggc tttatggata atatacagtt tgagaggttc
      181 aacaacagat cagattttcc tgggatggag cactgcgcac catggataga tcatcggagt
      241 ccagagtatt ggaaggagca cacacagagg gccctgaaag atattcggtt tatgagacaa
      301 gcactgaaat taatgatcca cacctacaac tacagtgcaa ctggatatca cacaatccag
      361 aggaggattg gctgccatgt cttgcctaga gggtacttca gtcatggatt cttagaatta
      421 gccttcaatg gccaggatta catcatgctg aatgaagacc tgaggacttg gaccacagtt
      481 ggcaaggcag ctgagattct caggaaagag tgggagaaac acagttttgc acaagccatg
      541 aagatttatt tggaggtttc atgtgtggac tcatttctca cagagctggc ttatgggaag
      601 gagattttgc tgagaataga tccccctaaa gtacaagtga tccgcaaggt cagacttaac
      661 aggaaaatta ccctgatgtg ctgggccctg agtttctacc ctcctgaaat taccctgacc
      721 tggcagagag atggatgcaa tcagatgcag gacatggagg tggtagagac caggcctgca
      781 ggggacggaa ctttccagaa atgggcagct gtggtggttt cttctgggga agagcaaaga
      841 tacacatgtc atgtgaatca taaggggcta cctgaggtca tcaccatgag gtgggagcct
      901 cctgagccta tcatcccaat tactactatt gttattgctg tagttctcgg agctctggtt
      961 gtgggagctg tgatgacttt tctgatatgg aagatgacta gaggtaagga aagggcatgg
     1021 ttttag
//
LOCUS       NM_001129776            1659 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus WAP, follistatin/kazal, immunoglobulin, kunitz
            and netrin domain containing 1 (Wfikkn1), mRNA.
ACCESSION   NM_001129776 XM_001060771 XM_343870
VERSION     NM_001129776.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Lee,Y.S. and Lee,S.J.
  TITLE     Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
  JOURNAL   Proc Natl Acad Sci U S A 110 (39), E3713-E3722 (2013)
   PUBMED   24019467
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Szlama,G., Kondas,K., Trexler,M. and Patthy,L.
  TITLE     WFIKKN1 and WFIKKN2 bind growth factors TGFbeta1, BMP2 and BMP4 but
            do not inhibit their signalling activity
  JOURNAL   FEBS J 277 (24), 5040-5050 (2010)
   PUBMED   21054789
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Nishida,A.T., Kobuke,K., Kojima,K., Ito,J., Honjo,T. and Tashiro,K.
  TITLE     OC29 is preferentially expressed in the presumptive sensory organ
            region of the otocyst
  JOURNAL   Dev Dyn 231 (4), 766-774 (2004)
   PUBMED   15497143
  REMARK    GeneRIF: OC29 may have a role in the early development of the inner
            ear sensory organ, particularly in the formation of the cristae of
            the semicircular canals [OC29]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 22, 2008 this sequence version replaced
            XM_343870.3, XM_001060771.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1659
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="WAP, follistatin/kazal, immunoglobulin, kunitz and
                     netrin domain containing 1"
                     /db_xref="GeneID:363555"
                     /db_xref="RGD:1565835"
     CDS             1..1659
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="WAP, kazal, immunoglobulin, kunitz and NTR
                     domain-containing protein 1; WAP, FS, Ig, KU, and
                     NTR-containing protein 1"
                     /codon_start=1
                     /product="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 1 precursor"
                     /protein_id="NP_001123248.1"
                     /db_xref="GeneID:363555"
                     /db_xref="RGD:1565835"
                     /translation="MPAPQPLLPLLFAFVLIHLTSETNLLPEPGSHPGMCPNQLSPHL
                     WVDAQSTCERECTRDQDCAASEKCCTNVCGLQSCVAARFPSGGPATPETAASCEDFQC
                     PQQGSNCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHVVP
                     CKHILSWPPSSPGPPETTARPTPGAAPMPPALYNSPSPQAVHVGGTASLHCDVSGRPP
                     PAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNAQLEDAGLYTCTARNAAGLL
                     RADFPLSVLQRATTQDRDPGVLALAECQPDTQACVGPPTPHHVLWRFDPQRGSCMTFP
                     ALKCDGAARGFETYEACQQACVRGPGDVCALPPVQGPCQGWEPRWAYSPLLQQCHPFI
                     YSGCEGNSNNFESRESCEDACPVPRTPPCRACRLKSKLALSLCRSDFAIVGRLTEVLE
                     EPEAAGGIARVALDDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNVTVGDGPLVIM
                     GEVREGVAVLDANSYVRAASEKRVKKIVELLEKKACELLNRFQD"
     sig_peptide     1..75
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5J5.1)"
     mat_peptide     76..1656
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /product="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 1. /id=PRO_0000307818"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5J5.1)"
     misc_feature    94..243
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="WAP-type (Whey Acidic Protein) 'four-disulfide
                     core'; Region: WAP; pfam00095"
                     /db_xref="CDD:459672"
     misc_feature    94..243
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="WAP-type (Whey Acidic Protein) 'four-disulfide
                     core'; Region: WAP; pfam00095"
                     /db_xref="CDD:459672"
     misc_feature    370..477
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Kazal type serine protease inhibitors and
                     follistatin-like domains. Kazal inhibitors inhibit serine
                     proteases, such as, trypsin, chyomotrypsin, avian
                     ovomucoids, and elastases. The inhibitory domain has one
                     reactive site peptide bond, which serves the...; Region:
                     KAZAL_FS; cd00104"
                     /db_xref="CDD:238052"
     misc_feature    370..477
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Kazal type serine protease inhibitors and
                     follistatin-like domains. Kazal inhibitors inhibit serine
                     proteases, such as, trypsin, chyomotrypsin, avian
                     ovomucoids, and elastases. The inhibitory domain has one
                     reactive site peptide bond, which serves the...; Region:
                     KAZAL_FS; cd00104"
                     /db_xref="CDD:238052"
     misc_feature    376..381
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Reactive bond.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00798; propagated
                     from UniProtKB/Swiss-Prot (P0C5J5.1); other site"
     misc_feature    568..852
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Third immunoglobulin-like domain of the human
                     WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR
                     domain-containing protein), and similar domains; member of
                     the I-set of Ig superfamily (IgSF) domains; Region:
                     IgI_3_WFIKKN-like; cd05765"
                     /db_xref="CDD:409422"
     misc_feature    568..852
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Third immunoglobulin-like domain of the human
                     WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR
                     domain-containing protein), and similar domains; member of
                     the I-set of Ig superfamily (IgSF) domains; Region:
                     IgI_3_WFIKKN-like; cd05765"
                     /db_xref="CDD:409422"
     misc_feature    568..579
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409422"
     misc_feature    568..579
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409422"
     misc_feature    592..603
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409422"
     misc_feature    592..603
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409422"
     misc_feature    616..639
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409422"
     misc_feature    616..639
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409422"
     misc_feature    658..675
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409422"
     misc_feature    658..675
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409422"
     misc_feature    676..684
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409422"
     misc_feature    676..684
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409422"
     misc_feature    688..705
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409422"
     misc_feature    688..705
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409422"
     misc_feature    727..747
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409422"
     misc_feature    727..747
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409422"
     misc_feature    787..813
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409422"
     misc_feature    787..813
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409422"
     misc_feature    820..852
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409422"
     misc_feature    820..852
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409422"
     misc_feature    904..1065
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    904..1065
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    order(925..939,949..957,1000..1002,1012..1014)
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    order(925..939,949..957,1000..1002,1012..1014)
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    1084..1242
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="second Kunitz domain of WAP, Kazal, immunoglobulin,
                     Kunitz and NTR domain-containing proteins; Region:
                     Kunitz_WFIKKN_2-like; cd22606"
                     /db_xref="CDD:438649"
     misc_feature    1084..1242
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="second Kunitz domain of WAP, Kazal, immunoglobulin,
                     Kunitz and NTR domain-containing proteins; Region:
                     Kunitz_WFIKKN_2-like; cd22606"
                     /db_xref="CDD:438649"
     misc_feature    order(1105..1119,1123..1131,1174..1176,1186..1188)
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438649"
     misc_feature    order(1105..1119,1123..1131,1174..1176,1186..1188)
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438649"
     misc_feature    1291..1623
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="NTR_like domain; a beta barrel with an
                     oligosaccharide/oligonucleotide-binding fold found in
                     netrins, complement proteins, tissue inhibitors of
                     metalloproteases (TIMP), and procollagen C-proteinase
                     enhancers (PCOLCE), amongst others. In netrins, the...;
                     Region: NTR_like; cl02512"
                     /db_xref="CDD:470599"
     misc_feature    1291..1623
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="NTR_like domain; a beta barrel with an
                     oligosaccharide/oligonucleotide-binding fold found in
                     netrins, complement proteins, tissue inhibitors of
                     metalloproteases (TIMP), and procollagen C-proteinase
                     enhancers (PCOLCE), amongst others. In netrins, the...;
                     Region: NTR_like; cl02512"
                     /db_xref="CDD:470599"
     misc_feature    1489..1491
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5J5.1); glycosylation site"
     exon            1..180
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /inference="alignment:Splign:2.1.0"
     exon            181..1659
                     /gene="Wfikkn1"
                     /gene_synonym="Oc29; RGD1565835"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcctgccc cacagccact cctgcctctg ctctttgcct tcgtgctcat ccatctgacc
       61 tcggagacca acctgctgcc agagcctgga agccatcctg gcatgtgccc caaccagctc
      121 agcccccacc tgtgggtcga cgcccagagc acctgtgagc gtgagtgtac cagggaccag
      181 gactgtgcgg catctgagaa gtgctgcacc aatgtgtgtg ggctgcagag ctgtgtggct
      241 gcccgcttcc ccagtggcgg cccagctaca cctgagacag cagcctcctg cgaagacttc
      301 caatgcccac aacagggttc caactgtgac atctgggatg ggcagccggt ttgtcgctgc
      361 cgtgaccgct gtgaaaaaga gcccagcttc acttgcgctt ctgatggcct cacctattac
      421 aaccgctgct atatggacgc agaagcctgc ctgcgaggtc tccacctgca tgtcgtaccc
      481 tgtaaacaca ttctcagttg gccacccagc agccccggac cacctgagac cactgctcgc
      541 ccaacccctg gggctgctcc catgccacct gccctataca acagcccctc accacaagcc
      601 gtgcatgtgg ggggaacagc cagcctccac tgtgacgtta gtggccgtcc accacctgcc
      661 gtgacatggg agaagcagag ccatcagcgg gagaacctga tcatgcgccc cgaccaaatg
      721 tacggcaacg tggttgtcac cagcattgga cagctagtgc tctacaatgc tcagctggag
      781 gatgcaggcc tgtacacctg caccgcacgg aatgctgctg gcctgctgcg ggctgacttt
      841 cccctttcgg ttttgcagcg ggcaactact caggacaggg acccaggtgt cctggccctg
      901 gctgagtgcc agcccgacac acaagcctgt gttggcccac ctacccccca tcatgtcctt
      961 tggcgctttg acccgcaacg aggcagctgc atgacattcc cagccctcaa atgcgatggg
     1021 gctgcccggg gctttgagac ctatgaggca tgccaacagg cctgtgtccg tggccctggg
     1081 gatgtctgtg cgctgcctcc agtccagggc ccctgccagg gctgggagcc acgctgggcc
     1141 tacagcccac tgctgcagca gtgccacccc tttatataca gtggctgtga gggaaacagc
     1201 aataactttg agagcaggga gagctgtgag gatgcttgcc ctgtaccacg cacaccaccc
     1261 tgccgtgcct gccgtctcaa gagcaagctg gccctgagct tgtgccgcag tgactttgcc
     1321 attgtgggca gactcacaga agtactggag gaacccgagg ctgcaggcgg cattgctcgt
     1381 gtggccttag atgacgtgct aaaggatgac aagatgggcc tcaagttctt aggcaccaaa
     1441 tacctggagg tgacactaag tggcatggac tgggcctgcc catgccccaa tgtgacagtt
     1501 ggcgatgggc cactggtcat catgggtgag gttcgtgaag gtgtggctgt gttggacgcc
     1561 aacagctacg tccgtgctgc cagtgagaag cgagtcaaga agattgtaga actgcttgag
     1621 aagaaggctt gtgaactgct caaccgcttc caagactag
//
LOCUS       NM_022672                492 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus ribosomal protein S14 (Rps14), mRNA.
ACCESSION   NM_022672
VERSION     NM_022672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 492)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Bayes,A., van de Lagemaat,L.N., Collins,M.O., Croning,M.D.,
            Whittle,I.R., Choudhary,J.S. and Grant,S.G.
  TITLE     Characterization of the proteome, diseases and evolution of the
            human postsynaptic density
  JOURNAL   Nat Neurosci 14 (1), 19-21 (2011)
   PUBMED   21170055
REFERENCE   6  (bases 1 to 492)
  AUTHORS   Tasheva,E.S. and Roufa,D.J.
  TITLE     Regulation of human RPS14 transcription by intronic antisense RNAs
            and ribosomal protein S14
  JOURNAL   Genes Dev 9 (3), 304-316 (1995)
   PUBMED   7867928
REFERENCE   7  (bases 1 to 492)
  AUTHORS   Paz,V., Chan,Y.L., Gluck,A. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein S14
  JOURNAL   Nucleic Acids Res 17 (22), 9484 (1989)
   PUBMED   2587275
REFERENCE   8  (bases 1 to 492)
  AUTHORS   Marion,M.J. and Marion,C.
  TITLE     Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on
            the surface of mammalian 40 S subunits and stabilize their
            conformation. A study with immobilized trypsin
  JOURNAL   FEBS Lett 232 (2), 281-285 (1988)
   PUBMED   3378620
REFERENCE   9  (bases 1 to 492)
  AUTHORS   Rhoads,D.D. and Roufa,D.J.
  TITLE     A cloned human ribosomal protein gene functions in rodent cells
  JOURNAL   Mol Cell Biol 7 (10), 3767-3774 (1987)
   PUBMED   3683397
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Collatz,E., Ulbrich,N., Tsurugi,K., Lightfoot,H.N., MacKinlay,W.,
            Lin,A. and Wool,I.G.
  TITLE     Isolation of eukaryotic ribosomal proteins. Purification and
            characterization of the 40 S ribosomal subunit proteins Sa, Sc,
            S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18,
            S19, S20, S21, S26, S27', and S29
  JOURNAL   J Biol Chem 252 (24), 9071-9080 (1977)
   PUBMED   925037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X15040.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15040.1, FQ211449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..492
                     /gene="Rps14"
                     /note="ribosomal protein S14"
                     /db_xref="GeneID:29284"
                     /db_xref="RGD:62025"
     exon            1..34
                     /gene="Rps14"
                     /inference="alignment:Splign:2.1.0"
     exon            35..185
                     /gene="Rps14"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..492
                     /gene="Rps14"
                     /note="40S ribosomal protein S14"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS11"
                     /protein_id="NP_073163.1"
                     /db_xref="GeneID:29284"
                     /db_xref="RGD:62025"
                     /translation="MAPRKGKDKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHV
                     TDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGG
                     NRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL"
     misc_feature    37..456
                     /gene="Rps14"
                     /note="40S ribosomal protein S14; Provisional; Region:
                     PTZ00129"
                     /db_xref="CDD:185465"
     misc_feature    37..456
                     /gene="Rps14"
                     /note="40S ribosomal protein S14; Provisional; Region:
                     PTZ00129"
                     /db_xref="CDD:185465"
     misc_feature    82..84
                     /gene="Rps14"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P62263; propagated from
                     UniProtKB/Swiss-Prot (P13471.3); phosphorylation site"
     misc_feature    427..489
                     /gene="Rps14"
                     /note="propagated from UniProtKB/Swiss-Prot (P13471.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    433..435
                     /gene="Rps14"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P62263; propagated from
                     UniProtKB/Swiss-Prot (P13471.3); phosphorylation site"
     misc_feature    451..453
                     /gene="Rps14"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P62263; propagated from
                     UniProtKB/Swiss-Prot (P13471.3); phosphorylation site"
     exon            186..347
                     /gene="Rps14"
                     /inference="alignment:Splign:2.1.0"
     exon            348..424
                     /gene="Rps14"
                     /inference="alignment:Splign:2.1.0"
     exon            425..492
                     /gene="Rps14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttccggtg gaggagtctg gagacgacgt tcagaaatgg cacctcgcaa ggggaaggac
       61 aagaaggaag aacaggtcat cagccttgga cctcaggtgg ctgaaggaga gaatgtattt
      121 ggtgtctgcc acatctttgc atccttcaat gatacctttg tccatgttac tgatctttct
      181 ggcaaggaaa ccatttgccg agtaactggt ggaatgaagg tgaaggctga ccgagatgag
      241 tcctctccgt atgcagccat gttggctgcc caggatgtgg cccagaggtg caaggaactg
      301 ggcatcactg ccctgcatat caaactccgg gccacaggag gaaacaggac caagacccct
      361 ggacctggag cccagtcagc cctcagagct cttgctcgct ctgggatgaa gattgggcgg
      421 attgaggatg tcacccccat cccctctgac agcactcgaa ggaagggtgg tcgtcggggt
      481 cgccgtctgt ga
//
LOCUS       NM_001106583            1648 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 15-like (Pgr15l),
            mRNA.
ACCESSION   NM_001106583 XM_001067990 XM_231463
VERSION     NM_001106583.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473966.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_231463.4, XM_001067990.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN14984021,
                              SAMN14984024 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1648
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="G protein-coupled receptor 15-like"
                     /db_xref="GeneID:296867"
                     /db_xref="RGD:1562685"
     exon            1..176
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /inference="alignment:Splign:2.1.0"
     exon            177..667
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    248..250
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="upstream in-frame stop codon"
     CDS             278..1648
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /codon_start=1
                     /product="G protein-coupled receptor 15-like"
                     /protein_id="NP_001100053.1"
                     /db_xref="GeneID:296867"
                     /db_xref="RGD:1562685"
                     /translation="MNASFKEASPFLLQMESAIDWLGENVSWVPSIEDQSCNHTTQNG
                     TNISSAEWGGPRGTVTKWLGGNPHIMAKIVLTFAYAVIIVISLFGNSLVCQVFVKHKE
                     TKKSTGLLIFNLAISDILIILLNSPFALARFLSGQWVFGRIMCHVSRFAQYCSLHVST
                     LTLMAVAMDRHRVILHPMKPRLTHSQSLFVVGVIWSIAVFLALPHAIYQNLFTLVNMD
                     GDVRSYCLPSFPGPSTLVSKYVDLGTFILLYILPLLVIVGTYSHLGKRLWIQNAIGDA
                     SARQLMAHYQKRKKSIRMLILIVLVFAVCWFPLNFYVVLISSAGVENDSVIFYAFHWF
                     AMSSTCYNPFIYCWLNRSFRAKLRSISSFRMQSLFVCSSSQVQQIQPRESHELRELRT
                     SSLLRVPLAVPEPQVFEDPSLATGDNSQVSVQGEWEDPDPSLDEEPGPSTRDSYFCIH
                     MQTSTH"
     misc_feature    494..1348
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="G protein-coupled receptor 83, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR83; cd15389"
                     /db_xref="CDD:320511"
     misc_feature    494..1348
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="G protein-coupled receptor 83, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR83; cd15389"
                     /db_xref="CDD:320511"
     misc_feature    497..577
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320511"
     misc_feature    497..577
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320511"
     misc_feature    596..673
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320511"
     misc_feature    596..673
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320511"
     misc_feature    order(662..664,671..676,710..727,731..736,743..745,
                     872..874,878..892,986..988,995..1003,1007..1015,
                     1019..1024,1193..1195,1202..1207,1211..1216,1223..1225,
                     1247..1252,1256..1264,1271..1273,1280..1285)
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320511"
     misc_feature    order(662..664,671..676,710..727,731..736,743..745,
                     872..874,878..892,986..988,995..1003,1007..1015,
                     1019..1024,1193..1195,1202..1207,1211..1216,1223..1225,
                     1247..1252,1256..1264,1271..1273,1280..1285)
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320511"
     misc_feature    710..802
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320511"
     misc_feature    710..802
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320511"
     misc_feature    833..898
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320511"
     misc_feature    833..898
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320511"
     misc_feature    986..1075
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320511"
     misc_feature    986..1075
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320511"
     misc_feature    1133..1225
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320511"
     misc_feature    1133..1225
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320511"
     misc_feature    1250..1327
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320511"
     misc_feature    1250..1327
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320511"
     exon            668..793
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /inference="alignment:Splign:2.1.0"
     exon            794..927
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1648
                     /gene="Pgr15l"
                     /gene_synonym="RGD1562685"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttggct gtggtgcgca gagccagagg cacctcgggc tctgaagtga gcacggacct
       61 ggacggacag gcggctagcc ctctagtccg ctagtccgtc ttcaggtctc ctctgcctgc
      121 ccagcagaca gaggctgcta gactcctagc ttcccagtcc gtctccggat tctaaggtgg
      181 aaccaggagt ttctgtttgc aaggatttgg aaaaaggact tcagtatcta tattctttat
      241 ggtcccttag gacctgctta attctcccct gacaaaaatg aatgcttcct tcaaggaagc
      301 atctcctttc ctgttacaaa tggaaagtgc cattgattgg ctcggagaaa atgtcagttg
      361 ggttccatca atcgaggatc aaagctgcaa tcatacaacc cagaatggaa ccaatatctc
      421 cagtgcagaa tggggagggc caagaggaac cgtcactaaa tggctagggg gcaatcccca
      481 catcatggcg aagatcgtgc tgacttttgc atatgcagtc atcatagtga tatctctctt
      541 tggcaactcc ctggtctgcc aagtttttgt caagcacaag gaaaccaaga aatccacagg
      601 ccttctcatc ttcaatctgg caatatctga cattttgata atcctgctca acagtccatt
      661 tgctctggct cgtttcctga gtggacagtg ggtgtttggt aggatcatgt gtcacgtcag
      721 tcggtttgct cagtactgtt ccctccatgt ttcaaccctt accctgatgg cagttgctat
      781 ggaccggcac cgggttattc tgcacccaat gaaaccaagg ctaacccact ctcagagctt
      841 atttgttgtt ggcgtgatct ggagtattgc agtgttcctt gctctgccac atgcaattta
      901 ccaaaatctc ttcactctcg tcaacatgga tggtgatgtc aggagctact gcctcccttc
      961 ctttcctgga cccagcacac tggtttcgaa gtatgtggac cttgggacat ttatcttgct
     1021 gtacatcctg ccacttctgg tgattgtcgg aacctattct cacctaggaa agaggttgtg
     1081 gattcaaaat gctattggtg atgcatcggc tcgtcaactt atggcacact accagaagcg
     1141 caagaagagc atccggatgc tgatacttat tgtattggtc tttgcagttt gttggtttcc
     1201 gcttaatttc tatgtggttc ttatttccag tgcaggtgta gaaaatgaca gtgtgatttt
     1261 ctatgccttt cattggtttg cgatgagtag cacctgctac aatcctttca tctattgttg
     1321 gctcaacagg agcttccgtg ccaaactgag atctatttcc tctttcagga tgcaatcact
     1381 gtttgtgtgt agtagctccc aggttcagca aatacaacca cgggagagtc atgagcttcg
     1441 ggagctccga acatcctcac tgctacgagt tcccctggct gttccagagc ctcaggtttt
     1501 tgaggatccc agtttggcca caggggataa ttcccaggtc tctgtccagg gggaatggga
     1561 ggatccagat ccctctctag atgaagagcc ggggccctca acccgggatt cttacttttg
     1621 catccacatg cagactagca ctcactaa
//
LOCUS       NM_001030044            1455 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus iroquois homeobox 5 (Irx5), mRNA.
ACCESSION   NM_001030044 XM_574208
VERSION     NM_001030044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Liu,D., Pattabiraman,V., Bacanamwo,M. and Anderson,L.M.
  TITLE     Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase
            transition in vascular smooth muscle cells by CDK2-dependent
            activation
  JOURNAL   Am J Physiol Cell Physiol 311 (2), C179-C189 (2016)
   PUBMED   27170637
  REMARK    GeneRIF: Irx5 plays an important role in VSMC G1/S-phase cell cycle
            checkpoint control.
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Bonnard,C., Strobl,A.C., Shboul,M., Lee,H., Merriman,B.,
            Nelson,S.F., Ababneh,O.H., Uz,E., Guran,T., Kayserili,H., Hamamy,H.
            and Reversade,B.
  TITLE     Mutations in IRX5 impair craniofacial development and germ cell
            migration via SDF1
  JOURNAL   Nat Genet 44 (6), 709-713 (2012)
   PUBMED   22581230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   He,W., Jia,Y. and Takimoto,K.
  TITLE     Interaction between transcription factors Iroquois proteins 4 and 5
            controls cardiac potassium channel Kv4.2 gene transcription
  JOURNAL   Cardiovasc Res 81 (1), 64-71 (2009)
   PUBMED   18815185
  REMARK    GeneRIF: Interaction between transcription factors Iroquois
            proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene
            transcription across the left ventricular wall of rodent hearts.
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Kerschensteiner,D., Liu,H., Cheng,C.W., Demas,J., Cheng,S.H.,
            Hui,C.C., Chow,R.L. and Wong,R.O.
  TITLE     Genetic control of circuit function: Vsx1 and Irx5 transcription
            factors regulate contrast adaptation in the mouse retina
  JOURNAL   J Neurosci 28 (10), 2342-2352 (2008)
   PUBMED   18322081
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Beisvag,V., Lehre,P.K., Midelfart,H., Aass,H., Geiran,O.,
            Sandvik,A.K., Laegreid,A., Komorowski,J. and Ellingsen,O.
  TITLE     Aetiology-specific patterns in end-stage heart failure patients
            identified by functional annotation and classification of
            microarray data
  JOURNAL   Eur J Heart Fail 8 (4), 381-389 (2006)
   PUBMED   16753336
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Rosati,B., Grau,F. and McKinnon,D.
  TITLE     Regional variation in mRNA transcript abundance within the
            ventricular wall
  JOURNAL   J Mol Cell Cardiol 40 (2), 295-302 (2006)
   PUBMED   16412459
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Cheng,C.W., Chow,R.L., Lebel,M., Sakuma,R., Cheung,H.O.,
            Thanabalasingham,V., Zhang,X., Bruneau,B.G., Birch,D.G., Hui,C.C.,
            McInnes,R.R. and Cheng,S.H.
  TITLE     The Iroquois homeobox gene, Irx5, is required for retinal cone
            bipolar cell development
  JOURNAL   Dev Biol 287 (1), 48-60 (2005)
   PUBMED   16182275
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Costantini,D.L., Arruda,E.P., Agarwal,P., Kim,K.H., Zhu,Y., Zhu,W.,
            Lebel,M., Cheng,C.W., Park,C.Y., Pierce,S.A., Guerchicoff,A.,
            Pollevick,G.D., Chan,T.Y., Kabir,M.G., Cheng,S.H., Husain,M.,
            Antzelevitch,C., Srivastava,D., Gross,G.J., Hui,C.C., Backx,P.H.
            and Bruneau,B.G.
  TITLE     The homeodomain transcription factor Irx5 establishes the mouse
            cardiac ventricular repolarization gradient
  JOURNAL   Cell 123 (2), 347-358 (2005)
   PUBMED   16239150
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ109812.1.
            
            On Aug 5, 2005 this sequence version replaced XM_574208.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ109812.1, AW252100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1455
                     /gene="Irx5"
                     /note="iroquois homeobox 5"
                     /db_xref="GeneID:498918"
                     /db_xref="RGD:1565518"
     CDS             1..1455
                     /gene="Irx5"
                     /note="iroquois homeobox protein 5"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-5"
                     /protein_id="NP_001025215.1"
                     /db_xref="GeneID:498918"
                     /db_xref="RGD:1565518"
                     /translation="MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSA
                     FSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYA
                     APLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
                     TWFVNARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPEAG
                     GTEQKAAAGCERLQGPLSPAGKETEGSLSDSDFKESPSEGRHDDLPRPPRAGEPSPAG
                     PATARLAEDAGPHYPAGAPAPGPHPSAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPK
                     LWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRASPAPAPARSPSAQCP
                     FPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTAGPGSHFNGLNQTVLNR
                     ADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI"
     misc_feature    order(346..351,355..357,415..417,433..435,472..474,
                     478..483,490..495,499..507,511..516)
                     /gene="Irx5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(346..351,355..357,415..417,433..435,472..474,
                     478..483,490..495,499..507,511..516)
                     /gene="Irx5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(352..354,481..483,490..495,502..504)
                     /gene="Irx5"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(352..354,481..483,490..495,502..504)
                     /gene="Irx5"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    391..507
                     /gene="Irx5"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    391..507
                     /gene="Irx5"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    <667..1233
                     /gene="Irx5"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <667..1233
                     /gene="Irx5"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            1..246
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     exon            247..652
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1455
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcctacc cgcagggcta cttgtaccag ccgtccgcct cgctggcgct ctactcgtgc
       61 cccgcataca gcaccagcgt catttcgggg ccccgcacgg atgagctcgg ccgctcttct
      121 tcgggctccg cattctcgcc ctacgctggc tccactgcct tcacggctcc ctcgccgggc
      181 tacaactcgc acctccagta cggtgccgat cccgcggctg cggccgccgc cgccttctcg
      241 tacgtgggct ctccctatga ccacactccc ggtatggcgg gttccttggg atatcaccct
      301 tacgccgcac ctctgggctc ctatccttat ggggatcccg cgtaccggaa gaacgccact
      361 cgggacgcca ctgccactct caaggcctgg ctcaatgagc accgaaagaa cccgtatccc
      421 actaagggcg agaagatcat gctggccatc atcaccaaaa tgaccctcac ccaggtgtcc
      481 acctggttcg tcaacgcgcg ccggcgcctc aagaaagaga acaagatgac gtggacgcca
      541 cggaaccgca gcgaggacga ggaggaggag gagaacattg atctggaaaa gaacgacgag
      601 gacgagccac agaagcccga ggacaagggc gacctcgagg gccccgaagc aggaggaaca
      661 gagcagaagg cggctgcggg ctgcgaacgg ctgcaggggc cgctcagccc cgccggcaag
      721 gaaactgaag gcagcctcag cgactcggat tttaaagagt cgccctccga aggccgccac
      781 gatgacctgc ccaggccccc gcgtgcaggc gagccctccc cggctgggcc cgcaactgcg
      841 cgtctggcgg aggatgcggg tcctcactac cctgcgggtg cgccggcgcc cggcccgcac
      901 ccatcagccg gagagttgcc ccccggctcg ggcggatcct cggtcatcca ctcaccaccg
      961 ccacctccgc caccgcctcc ggccgtgcta gccaagccca aactgtggtc tctggcagag
     1021 atagccacat cctcggacaa ggtcaaggac gggggcggag ggagcgaggg ctctccgtgc
     1081 ccaccgtgcc ccgggcccat aggcgggcaa acccttggag gcagccgcgc ttctcctgct
     1141 ccggcgcccg cacgctcacc ctcggcgcag tgtccctttc ctggcgggac cgtgctgtcc
     1201 cggcctctct actacacggc gcccttctat ccgggctaca cgaactatgg ctccttcgga
     1261 catcttcacg gccacccagg gccagggcca ggccctacag cgggtcctgg ctctcatttc
     1321 aatggattaa accagacggt gttgaatcgt gcggacgttt tggctaaaga cccgaaaatg
     1381 ttgcggagtc agtctcagct agacctgtgc aaagactccc cctatgaatt gaagaaaggt
     1441 atgtccgaca tttaa
//
LOCUS       NM_001107239            3219 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus adenylate cyclase 1 (Adcy1), mRNA.
ACCESSION   NM_001107239 XM_001053224 XM_223616
VERSION     NM_001107239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Zhang,X., Pizzoni,A., Hong,K., Naim,N., Qi,C., Korkhov,V. and
            Altschuler,D.L.
  TITLE     CAP1 binds and activates adenylyl cyclase in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (24) (2021)
   PUBMED   34099549
  REMARK    GeneRIF: CAP1 binds and activates adenylyl cyclase in mammalian
            cells.
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Santos-Cortez,R.L., Lee,K., Giese,A.P., Ansar,M., Amin-Ud-Din,M.,
            Rehn,K., Wang,X., Aziz,A., Chiu,I., Hussain Ali,R., Smith,J.D.,
            Shendure,J., Bamshad,M., Nickerson,D.A., Ahmed,Z.M., Ahmad,W.,
            Riazuddin,S. and Leal,S.M.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing
            impairment in humans and defects in hair cell function and hearing
            in zebrafish
  JOURNAL   Hum Mol Genet 23 (12), 3289-3298 (2014)
   PUBMED   24482543
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Hwang,C.K., Chaurasia,S.S., Jackson,C.R., Chan,G.C., Storm,D.R. and
            Iuvone,P.M.
  TITLE     Circadian rhythm of contrast sensitivity is regulated by a
            dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling
            pathway in retinal ganglion cells
  JOURNAL   J Neurosci 33 (38), 14989-14997 (2013)
   PUBMED   24048828
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Ehling,P., Kanyshkova,T., Baumann,A., Landgraf,P., Meuth,S.G.,
            Pape,H.C. and Budde,T.
  TITLE     Adenylyl cyclases: expression in the developing rat thalamus and
            their role in absence epilepsy
  JOURNAL   J Mol Neurosci 48 (1), 45-52 (2012)
   PUBMED   22531884
  REMARK    GeneRIF: Despite previous hints pointing to a major contribution of
            ACs, the presented data show that there is no apparent causality
            between AC activity and the occurrence of the epileptic phenotype.
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Jensen,J.B., Mikkelsen,J.D. and Mork,A.
  TITLE     Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase
            type 2 in the rat hippocampus following antidepressant treatment
  JOURNAL   Eur Neuropsychopharmacol 10 (2), 105-111 (2000)
   PUBMED   10706991
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Wong,S.T., Athos,J., Figueroa,X.A., Pineda,V.V., Schaefer,M.L.,
            Chavkin,C.C., Muglia,L.J. and Storm,D.R.
  TITLE     Calcium-stimulated adenylyl cyclase activity is critical for
            hippocampus-dependent long-term memory and late phase LTP
  JOURNAL   Neuron 23 (4), 787-798 (1999)
   PUBMED   10482244
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Villacres,E.C., Wong,S.T., Chavkin,C. and Storm,D.R.
  TITLE     Type I adenylyl cyclase mutant mice have impaired mossy fiber
            long-term potentiation
  JOURNAL   J Neurosci 18 (9), 3186-3194 (1998)
   PUBMED   9547227
REFERENCE   9  (bases 1 to 3219)
  AUTHORS   Matsuoka,I., Suzuki,Y., Defer,N., Nakanishi,H. and Hanoune,J.
  TITLE     Differential expression of type I, II, and V adenylyl cyclase gene
            in the postnatal developing rat brain
  JOURNAL   J Neurochem 68 (2), 498-506 (1997)
   PUBMED   9003034
REFERENCE   10 (bases 1 to 3219)
  AUTHORS   Tzavara,E.T., Pouille,Y., Defer,N. and Hanoune,J.
  TITLE     Diurnal variation of the adenylyl cyclase type 1 in the rat pineal
            gland
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11208-11212 (1996)
   PUBMED   8855334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474055.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223616.4, XM_001053224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="adenylate cyclase 1"
                     /db_xref="GeneID:305509"
                     /db_xref="RGD:1309318"
     exon            1..495
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /EC_number="4.6.1.1"
                     /note="adenylate cyclase 1 (brain)"
                     /codon_start=1
                     /product="adenylate cyclase type 1"
                     /protein_id="NP_001100709.1"
                     /db_xref="GeneID:305509"
                     /db_xref="RGD:1309318"
                     /translation="MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLL
                     VTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLR
                     LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFT
                     GLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCC
                     VEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVM
                     EAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPG
                     LILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEK
                     LRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQ
                     LQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQ
                     CFPGCLTIQIRTALCVFIVVLIYSVAQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVL
                     PALPCESAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGG
                     GALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKR
                     ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC
                     LRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTL
                     ADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRM
                     DSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGSSSHSRS
                     LRLERRMFPYGRGGGGQARRPPLCPAAGPPIKPGLSPAPTSQYLSSTAAGKEA"
     misc_feature    <331..732
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylyl cyclase N-terminal extracellular and
                     transmembrane region; Region: AC_N; pfam16214"
                     /db_xref="CDD:318454"
     misc_feature    <331..732
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylyl cyclase N-terminal extracellular and
                     transmembrane region; Region: AC_N; pfam16214"
                     /db_xref="CDD:318454"
     misc_feature    736..1284
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylate and Guanylate cyclase catalytic domain;
                     Region: Guanylate_cyc; pfam00211"
                     /db_xref="CDD:425528"
     misc_feature    736..1284
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylate and Guanylate cyclase catalytic domain;
                     Region: Guanylate_cyc; pfam00211"
                     /db_xref="CDD:425528"
     misc_feature    order(772..774,778..795,898..900,904..912,919..921,
                     1105..1113,1123..1128,1135..1140,1240..1242)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="nucleotidyl binding site [active]"
                     /db_xref="CDD:143636"
     misc_feature    order(772..774,778..795,898..900,904..912,919..921,
                     1105..1113,1123..1128,1135..1140,1240..1242)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="nucleotidyl binding site [active]"
                     /db_xref="CDD:143636"
     misc_feature    order(778..780,910..912)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143636"
     misc_feature    order(778..780,910..912)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143636"
     misc_feature    order(793..795,829..831,838..843,850..852,862..864,
                     898..903,1069..1071,1078..1080,1108..1119,1126..1128,
                     1240..1242)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143636"
     misc_feature    order(793..795,829..831,838..843,850..852,862..864,
                     898..903,1069..1071,1078..1080,1108..1119,1126..1128,
                     1240..1242)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143636"
     misc_feature    2431..3024
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylate and Guanylate cyclase catalytic domain;
                     Region: Guanylate_cyc; pfam00211"
                     /db_xref="CDD:425528"
     misc_feature    2431..3024
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="Adenylate and Guanylate cyclase catalytic domain;
                     Region: Guanylate_cyc; pfam00211"
                     /db_xref="CDD:425528"
     misc_feature    order(2467..2469,2473..2490,2614..2616,2620..2628,
                     2635..2637,2845..2853,2863..2868,2875..2880,2986..2988)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="nucleotidyl binding site [active]"
                     /db_xref="CDD:143636"
     misc_feature    order(2467..2469,2473..2490,2614..2616,2620..2628,
                     2635..2637,2845..2853,2863..2868,2875..2880,2986..2988)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="nucleotidyl binding site [active]"
                     /db_xref="CDD:143636"
     misc_feature    order(2473..2475,2626..2628)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143636"
     misc_feature    order(2473..2475,2626..2628)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143636"
     misc_feature    order(2488..2490,2536..2538,2545..2550,2557..2559,
                     2569..2571,2614..2619,2809..2811,2818..2820,2848..2859,
                     2866..2868,2986..2988)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143636"
     misc_feature    order(2488..2490,2536..2538,2545..2550,2557..2559,
                     2569..2571,2614..2619,2809..2811,2818..2820,2848..2859,
                     2866..2868,2986..2988)
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:143636"
     exon            496..645
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..764
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..876
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1004
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1163
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1305
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1461
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1656
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1754
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1839
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1929
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2183
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2310
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2427
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2574
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2673
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2788
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2913
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgcggct acacgttgcg gctggagcag gcggccacgc tgaaagcgct ggcggtgctt
       61 agcctgctgg cgggagccct ggcgctggcc gagctgctgg gcgcaccggg gccagcgcct
      121 ggcctcgcca aggggtcgca cccagtgcac tgcatccttt tcctggcgct gttcgtggtc
      181 accaatgtcc gatccctgca ggtgtcccag ctgcagcagg tcggtcagct ggcgctgttc
      241 ttcagcctca ccttcgcgct actctgctgc cccttcgcgc tgggcggccc cgcgaggagc
      301 tctgcgggag gcgcaatggg ctcggcggtt gccgaacagg gggtttggca actccttttg
      361 gtcaccttcg tgtcctatgc cttgctgccc gtgcgcagcc tactggccat cggcttcggg
      421 ctcgtggtgg ctgcctcgca cttactggtc acagccgcct tggtccctgc caagcgccca
      481 cgtctctgga ggacgcttgg tgccaatgcc ctgctcttct ttggtgtgaa catgtatggc
      541 gtcttcgtgc ggatcttgac tgagcgctcc cagaggaagg ccttcctgca ggctcgaaac
      601 tgcattgagg accggctgcg gctggaagat gagaatgaga aacaggagcg gttgctcatg
      661 agcctcttgc cccggaatgt cgccatggag atgaaggaag acttcctgaa gccccctgag
      721 aggatatttc acaagattta catccagagg cacgacaatg tgagcatcct gtttgcagac
      781 atcgtgggtt tcacaggtct ggcgtcccag tgcacggccc aggagctggt gaaactgctc
      841 aatgaactct ttggcaagtt cgatgagtta gccacggaaa accactgtcg ccgaatcaag
      901 atccttggag actgctacta ctgtgtgtct ggcctcaccc agcccaagac ggatcacgcc
      961 cactgctgtg tggagatggg acttgacatg atcgatacca tcacatccgt ggctgaggct
     1021 actgaagtag acctgaacat gcgtgtgggc ctacacactg gcagggtcct ctgtggtgtc
     1081 ctgggcctac gcaagtggca gtacgacgta tggtccaacg acgtcaccct ggccaatgtc
     1141 atggaggctg ctggcttacc agggaaggtc cacatcacga agacaaccct tgcgtgcttg
     1201 aacggggact acgaggtgga gccgggccac ggccatgaga ggaacacctt tctgagaact
     1261 cacaacatcg agaccttctt tattgtgcca tcccatcgga ggaagatatt tccaggtttg
     1321 attctctcgg atatcaaacc agccaagagg atgaagttca agaccgtctg ctacctgctg
     1381 gtgcagctca tgcattgccg gaaaatgttc aaggctgaga tccccttctc caacgtaatg
     1441 acctgtgagg atgatgacaa gcgaagggca ttgagaacgg cctcggagaa gctcagaaac
     1501 cgttcgtcat tctctaccaa cgtggtctac accactccgg gtacgcgtgt caacaggtac
     1561 atcagccgcc ttcttgaagc ccgccagaca gagctggaga tggccgacct gaacttcttt
     1621 accctcaagt acaagcatgt tgaacgggaa caaaaatacc accagcttca agatgagtac
     1681 ttcaccagcg ccgttgtcct cgccctcatc ctggctacct tatttgggct tatctacctt
     1741 ctggtaatcc cacagagcgt ggctgtcctg ctgctgctgg tgttttctat ctgcttcttg
     1801 gtggcctgta ccctgtacct gcacatcacg agggtccagt gttttccagg gtgcctgacc
     1861 atccagatcc gcaccgctct gtgtgtgttc atcgtggtct taatctactc agtagctcaa
     1921 ggatgtgtgg tgagctgtct gccttgggcc tggagctctc actccaacag ctccctagtg
     1981 gtcctcgcag ctggtggccg gcgcactgtg ctgcctgccc tgccctgtga gtctgcacac
     2041 catggcctgc tctgctgcct ggtgggcacc ctcccactag ccatattcct gcgggtgtcc
     2101 tccttgccaa agatgatcct gctgtctggg ctgacgactt cctacatcct tgtcctggag
     2161 ctcagtggat acaccaaggt tgggggcggt gccctctctg ggcgcagcta tgagcccatc
     2221 atggctatcc tgctgttctc atgcacgctg gccctgcacg ccaggcaggt ggacgtcagg
     2281 ctacggctgg actacctctg ggcagcacag gcggaggagg aacgggacga catggagagg
     2341 gtaaagctgg acaacaagag gatcctcttc aacctcctgc cagcgcacgt cgcacagcac
     2401 ttcctcatgt ccaatccccg gaacatggat ctctattacc agtcctactc ccaggtgggc
     2461 gtcatgttcg cctccatccc caacttcaac gacttctaca tagaactgga tggcaacaac
     2521 atgggcgttg agtgtctgcg gctcctcaat gagatcattg ctgactttga tgagctcatg
     2581 gacaaggact tctacaagga cctggagaag atcaagacca ttgggagtac ctatatggct
     2641 gccgtggggc tggcgcccac agcaggaacc agggctaaga agtccatctc ttcccatctg
     2701 agcacgctgg cagactttgc catcgacatg tttgatgtcc tggatgagat caactaccag
     2761 tcctacaacg acttcgttct ccgagtcggc atcaacgttg gccccgtggt cgctggagtg
     2821 atcggtgctc gcaggcccca gtacgacatc tggggaaaca cagtcaatgt ggccagtcgg
     2881 atggatagca ctggggtcca gggaagaatt caggtgactg aggaagtcca ccgactgctg
     2941 aacaggtgct cataccagtt tgtgtgcaga ggcaaagtca gcgtcaaggg caagggagag
     3001 atgctaacgt actttctaga aggcaggact gatgggagca gttcccacag caggtccctt
     3061 cgcttggagc gaaggatgtt tccttatggg agaggcggcg gaggccaggc caggcggccc
     3121 ccattgtgtc ctgcagctgg acccccaatc aaaccggggc tctctccagc ccccactagc
     3181 cagtacctgt catccacagc agcagggaag gaagcctag
//
LOCUS       NM_001101019             789 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus C-type lectin domain family 2 member D2 like 1
            (Clec2d2l1), mRNA.
ACCESSION   NM_001101019 XM_001071896
VERSION     NM_001101019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 789)
  AUTHORS   Kveberg,L., Dai,K.Z., Westgaard,I.H., Daws,M.R., Fossum,S.,
            Naper,C. and Vaage,J.T.
  TITLE     Two major groups of rat NKR-P1 receptors can be distinguished based
            on chromosomal localization, phylogenetic analysis and Clr ligand
            binding
  JOURNAL   Eur J Immunol 39 (2), 541-551 (2009)
   PUBMED   19130483
REFERENCE   2  (bases 1 to 789)
  AUTHORS   Voigt,S., Mesci,A., Ettinger,J., Fine,J.H., Chen,P., Chou,W. and
            Carlyle,J.R.
  TITLE     Cytomegalovirus evasion of innate immunity by subversion of the
            NKR-P1B:Clr-b missing-self axis
  JOURNAL   Immunity 26 (5), 617-627 (2007)
   PUBMED   17462921
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FJ404472.1.
            
            On Jul 20, 2012 this sequence version replaced NM_001101019.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ404472.1, EF100687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..789
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /note="C-type lectin domain family 2 member D2 like 1"
                     /db_xref="GeneID:689757"
                     /db_xref="RGD:1588731"
     CDS             1..789
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member D3"
                     /protein_id="NP_001094489.2"
                     /db_xref="GeneID:689757"
                     /db_xref="RGD:1588731"
                     /translation="MSPLNPRPYSMSSSAHLQDAPPLLSGTLTQNEGQTSLRQSSSCG
                     PSAASASESLSGYTESRIPHSKVRQGKGLRSIFPESRVKRYCCYGGVITVVAIAIVVP
                     LSVTLSVKQMEQTSINNTFAASINNTSAASINNTSAACPSNWTEYGNKCFYFSEYTSN
                     WTFSKDFCAAQGAELARFDTEEELNFLKRYKGSSGYWIGLHRESSEHPWKWTDNTQYN
                     NLVPIRGDGQCGFLSDQLNISSSRVYVERPWICSKPKKYISQSQ"
     misc_feature    <247..759
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /note="C-type lectin-like protein; Provisional; Region:
                     PHA02642"
                     /db_xref="CDD:165024"
     misc_feature    <247..759
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /note="C-type lectin-like protein; Provisional; Region:
                     PHA02642"
                     /db_xref="CDD:165024"
     exon            1..193
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /inference="alignment:Splign:2.1.0"
     exon            194..325
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /inference="alignment:Splign:2.1.0"
     exon            326..552
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /inference="alignment:Splign:2.1.0"
     exon            553..659
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /inference="alignment:Splign:2.1.0"
     exon            660..789
                     /gene="Clec2d2l1"
                     /gene_synonym="Clec2d3; RGD1563033"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctccct tgaatcctag gccatactca atgtcgtcca gtgcacacct acaggatgct
       61 cccccactcc tctccgggac ccttacacag aatgaaggac agacctcctt gaggcagagt
      121 agcagctgtg gtccgtctgc tgcctctgcc tctgagtcat tgtcaggtta caccgagtca
      181 agaattcctc acagtaaagt gcgccaagga aagggtctca gaagcatctt ccctgagtct
      241 cgtgttaagc gttactgctg ctatggagga gtgatcacag tcgttgctat agctatagtt
      301 gttcctcttt ctgttacttt gtcagtaaaa cagatggaac aaacctcaat caataatacc
      361 ttcgctgcct caatcaataa tacctccgct gcctcaatca ataatacctc tgctgcttgc
      421 ccgagcaact ggactgaata tggtaataaa tgtttttatt tttctgaata tacaagtaac
      481 tggacattca gcaaggactt ctgcgcggca caaggggccg agctagcacg atttgacacc
      541 gaggaggagc tgaatttcct aaagagatac aaagggagtt cgggttactg gatcggtctg
      601 cacagagagt catcagagca cccttggaag tggacagaca atactcagta taacaacttg
      661 gttcccatcc gaggagatgg acaatgtggc ttcctgagtg accagctcaa catcagcagt
      721 agcagggtct atgtagaaag gccttggatt tgtagcaagc ccaaaaaata catctcacag
      781 tcccagtag
//
LOCUS       NM_001256529             297 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed 3 (Pate3), mRNA.
ACCESSION   NM_001256529 XM_002727025 XM_002729926
VERSION     NM_001256529.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Rajesh,A. and Yenugu,S.
  TITLE     Genomic organization, tissue distribution and functional
            characterization of the rat Pate gene cluster
  JOURNAL   PLoS One 7 (3), e32633 (2012)
   PUBMED   22479333
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from HQ916281.1.
            
            On or before Feb 6, 2012 this sequence version replaced
            XM_002729926.1, XM_002727025.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ916281.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..297
                     /gene="Pate3"
                     /note="prostate and testis expressed 3"
                     /db_xref="GeneID:100361414"
                     /db_xref="RGD:2320151"
     CDS             1..297
                     /gene="Pate3"
                     /note="prostate and testis expressed DJ; prostate and
                     testis expressed protein 3; prostate and testis expressed
                     DJ-like"
                     /codon_start=1
                     /product="prostate and testis expressed protein 3
                     precursor"
                     /protein_id="NP_001243458.1"
                     /db_xref="GeneID:100361414"
                     /db_xref="RGD:2320151"
                     /translation="MNRHFLLLVSLFCLIVEATTLKCTTCHLRTQSDHCRRGFGVCLA
                     QKHETCMSLRIYSNGSLQTSYMVCQRFCKNLAYNFNNRTYIHKCCNYDFCNFRL"
     sig_peptide     1..54
                     /gene="Pate3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    49..288
                     /gene="Pate3"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 3 (PATE3) and similar proteins;
                     Region: TFP_LU_ECD_PATE3; cd23579"
                     /db_xref="CDD:467109"
     misc_feature    49..288
                     /gene="Pate3"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 3 (PATE3) and similar proteins;
                     Region: TFP_LU_ECD_PATE3; cd23579"
                     /db_xref="CDD:467109"
     exon            1..49
                     /gene="Pate3"
                     /inference="alignment:Splign:2.1.0"
     exon            50..172
                     /gene="Pate3"
                     /inference="alignment:Splign:2.1.0"
     exon            173..297
                     /gene="Pate3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacaggc acttcttgct gctcgtctcc ctcttctgcc tcattgtgga agcaacaaca
       61 ctgaagtgta caacatgcca cctccgcaca cagtcagacc attgcagaag aggctttggt
      121 gtttgccttg ctcagaagca cgaaacatgc atgagcttga ggatctactc caatggctct
      181 ctccagacct catacatggt gtgtcagaga ttctgcaaga atttggcata caacttcaac
      241 aatcgaactt atattcataa atgttgcaac tatgattttt gtaacttcag actttaa
//
LOCUS       NM_001267780             327 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed protein F (Pate-f),
            mRNA.
ACCESSION   NM_001267780
VERSION     NM_001267780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Rajesh,A. and Yenugu,S.
  TITLE     Genomic organization, tissue distribution and functional
            characterization of the rat Pate gene cluster
  JOURNAL   PLoS One 7 (3), e32633 (2012)
   PUBMED   22479333
  REMARK    GeneRIF: Data show that PATE and PATE-F proteins were found to be
            expressed abundantly in the male reproductive tract and on the
            sperm.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JF412806.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF412806.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..327
                     /gene="Pate-f"
                     /note="prostate and testis expressed protein F"
                     /db_xref="GeneID:100913081"
                     /db_xref="RGD:6484596"
     CDS             1..327
                     /gene="Pate-f"
                     /note="prostate and testis expressed protein 2-like"
                     /codon_start=1
                     /product="prostate and testis expressed protein F
                     precursor"
                     /protein_id="NP_001254709.1"
                     /db_xref="GeneID:100913081"
                     /db_xref="RGD:6484596"
                     /translation="MGKLLLLLLLLGAFVLLLIQAQERICMSCHMFVNGKCVESEGKC
                     TMEDGGACRTRDIYLFNARGGFLYNHTMLECSKSCKASEESYFHLKISTFCCKSQDFC
                     NKYKGK"
     sig_peptide     1..63
                     /gene="Pate-f"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    64..309
                     /gene="Pate-f"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 2 (PATE2) and similar proteins;
                     Region: TFP_LU_ECD_PATE2; cd23578"
                     /db_xref="CDD:467108"
     misc_feature    64..309
                     /gene="Pate-f"
                     /note="extracellular domain (ECD) found in prostate and
                     testis expressed protein 2 (PATE2) and similar proteins;
                     Region: TFP_LU_ECD_PATE2; cd23578"
                     /db_xref="CDD:467108"
     exon            1..61
                     /gene="Pate-f"
                     /inference="alignment:Splign:2.1.0"
     exon            62..190
                     /gene="Pate-f"
                     /inference="alignment:Splign:2.1.0"
     exon            191..327
                     /gene="Pate-f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcaagc tcctgctcct gctcctgctg ctaggagctt ttgttcttct gttgatccaa
       61 gcccaagaaa gaatatgcat gtcctgccac atgtttgtga atggcaagtg tgtagaaagt
      121 gaaggtaaat gcaccatgga ggacggcggt gcatgcagaa ccagggacat ctatcttttc
      181 aatgcaagag gtgggtttct ctacaaccac actatgctgg agtgttctaa atcttgtaag
      241 gcttcagaag agagttattt tcatctaaaa atttcaactt tttgttgcaa aagtcaagac
      301 ttctgcaata aatataaggg aaagtga
//
LOCUS       NM_001004216            1707 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus NADPH oxidase 3 (Nox3), mRNA.
ACCESSION   NM_001004216 XM_217848
VERSION     NM_001004216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Michihara,A., Oda,A. and Mido,M.
  TITLE     High Expression Levels of NADPH Oxidase 3 in the Cerebrum of
            Ten-Week-Old Stroke-Prone Spontaneously Hypertensive Rats
  JOURNAL   Biol Pharm Bull 39 (2), 252-258 (2016)
   PUBMED   26830484
  REMARK    GeneRIF: These results suggested that the high expression levels of
            NOX3 increased oxidative stress in stroke-prone hypertensive rat
            cerebrum.
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Mukherjea,D., Jajoo,S., Kaur,T., Sheehan,K.E., Ramkumar,V. and
            Rybak,L.P.
  TITLE     Transtympanic administration of short interfering (si)RNA for the
            NOX3 isoform of NADPH oxidase protects against cisplatin-induced
            hearing loss in the rat
  JOURNAL   Antioxid Redox Signal 13 (5), 589-598 (2010)
   PUBMED   20214492
  REMARK    GeneRIF: NOX3 regulates stress-related genes in the cochlea, such
            as TRPV1 and KIM-1, and initiates apoptosis in the cochlea.
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Mukherjea,D., Jajoo,S., Whitworth,C., Bunch,J.R., Turner,J.G.,
            Rybak,L.P. and Ramkumar,V.
  TITLE     Short interfering RNA against transient receptor potential
            vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
  JOURNAL   J Neurosci 28 (49), 13056-13065 (2008)
   PUBMED   19052196
  REMARK    GeneRIF: These data provide a link between NOX3 and TRPV1 in
            cisplatin-induced hearing loss and suggest that targeting these
            proteins for knockdown by siRNA could serve as a novel approach in
            treating cisplatin ototoxicity.
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Nakano,Y., Banfi,B., Jesaitis,A.J., Dinauer,M.C., Allen,L.A. and
            Nauseef,W.M.
  TITLE     Critical roles for p22phox in the structural maturation and
            subcellular targeting of Nox3
  JOURNAL   Biochem J 403 (1), 97-108 (2007)
   PUBMED   17140397
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Banfi,B., Malgrange,B., Knisz,J., Steger,K., Dubois-Dauphin,M. and
            Krause,K.H.
  TITLE     NOX3, a superoxide-generating NADPH oxidase of the inner ear
  JOURNAL   J Biol Chem 279 (44), 46065-46072 (2004)
   PUBMED   15326186
  REMARK    GeneRIF: NOX3 is a relevant source of ROS generation in the
            cochlear and vestibular systems and that NOX3-dependent ROS
            generation might contribute to hearing loss and balance problems in
            response to ototoxic drugs.
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Evidence for macular gravity receptor modulation of hypothalamic,
            limbic and autonomic nuclei
  JOURNAL   Neuroscience 129 (2), 461-471 (2004)
   PUBMED   15501603
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Fuller,P.M., Jones,T.A., Jones,S.M. and Fuller,C.A.
  TITLE     Neurovestibular modulation of circadian and homeostatic regulation:
            vestibulohypothalamic connection?
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15723-15728 (2002)
   PUBMED   12434016
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Jones,S.M., Erway,L.C., Bergstrom,R.A., Schimenti,J.C. and
            Jones,T.A.
  TITLE     Vestibular responses to linear acceleration are absent in
            otoconia-deficient C57BL/6JEi-het mice
  JOURNAL   Hear Res 135 (1-2), 56-60 (1999)
   PUBMED   10491954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY573239.1.
            
            On Sep 10, 2004 this sequence version replaced XM_217848.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY573239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132265,
                                           SAMD00132268 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1707
                     /gene="Nox3"
                     /note="NADPH oxidase 3"
                     /db_xref="GeneID:292279"
                     /db_xref="RGD:1303190"
     CDS             1..1707
                     /gene="Nox3"
                     /note="superoxide producing enzyme"
                     /codon_start=1
                     /product="NADPH oxidase 3"
                     /protein_id="NP_001004216.1"
                     /db_xref="GeneID:292279"
                     /db_xref="RGD:1303190"
                     /translation="MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTR
                     VILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFH
                     KLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTL
                     YTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLA
                     IHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVV
                     LYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLE
                     WHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGS
                     LADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFE
                     WFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTF
                     YGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKE
                     NF"
     misc_feature    37..99
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    148..210
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    283..1641
                     /gene="Nox3"
                     /note="Predicted ferric reductase [Inorganic ion transport
                     and metabolism]; Region: COG4097"
                     /db_xref="CDD:443273"
     misc_feature    283..1641
                     /gene="Nox3"
                     /note="Predicted ferric reductase [Inorganic ion transport
                     and metabolism]; Region: COG4097"
                     /db_xref="CDD:443273"
     misc_feature    310..372
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    502..564
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    604..666
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    712..714
                     /gene="Nox3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q672K1.1); glycosylation site"
     misc_feature    883..1704
                     /gene="Nox3"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     Region: NOX_Duox_like_FAD_NADP; cd06186"
                     /db_xref="CDD:99783"
     misc_feature    883..1704
                     /gene="Nox3"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     Region: NOX_Duox_like_FAD_NADP; cd06186"
                     /db_xref="CDD:99783"
     misc_feature    order(964..966,1006..1017,1054..1062,1069..1080,
                     1225..1227)
                     /gene="Nox3"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(964..966,1006..1017,1054..1062,1069..1080,
                     1225..1227)
                     /gene="Nox3"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1006..1008,1012..1017)
                     /gene="Nox3"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1006..1008,1012..1017)
                     /gene="Nox3"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    1186..1248
                     /gene="Nox3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q672K1.1);
                     transmembrane region"
     misc_feature    1210..1242
                     /gene="Nox3"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    1210..1242
                     /gene="Nox3"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1210..1212,1222..1233,1237..1239)
                     /gene="Nox3"
                     /note="beta-alpha-beta stucture motif; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1210..1212,1222..1233,1237..1239)
                     /gene="Nox3"
                     /note="beta-alpha-beta stucture motif; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1225..1230,1324..1332,1606..1611)
                     /gene="Nox3"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1225..1230,1324..1332,1606..1611)
                     /gene="Nox3"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1318..1323,1330..1332)
                     /gene="Nox3"
                     /note="NADP ribose binding motif [chemical binding]; other
                     site"
                     /db_xref="CDD:99783"
     misc_feature    order(1318..1323,1330..1332)
                     /gene="Nox3"
                     /note="NADP ribose binding motif [chemical binding]; other
                     site"
                     /db_xref="CDD:99783"
     exon            1..48
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            49..144
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..255
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..340
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..486
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..668
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..798
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..891
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1145
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1308
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1455
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1580
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1707
                     /gene="Nox3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccgacgt gctggatttt gaacgagagt gtgtccttcg tggttgctct cttgtggctg
       61 gcaataaata tctatctgtt tattgacacg ttctgctggt atgctgaaga ggagtctttc
      121 ttttatacac gagttattct gggttccgca ttggcatggg cccgggcatc tgccgtgtgc
      181 ctgaatttta actgcatgct aattctgtta cctgtcagtc ggaacttcgt ttcactggtg
      241 agaggaacga gcgtgtgctg tagaggaccg tggagacggc aactagacaa aaacctcaag
      301 ttccacaagc tcgttgccta cgggatagct gttaattcag ttatccacat tgtggcacac
      361 ttgttcaacc tggagcgtta tcacctgggt caggccaagg atgctgaagg gctgctggct
      421 gcgctttcca aacttggcaa tgccccaaat gaaagctacc tcaatccggt ccgcaccttg
      481 tatacgggta caaccactca gctattaatg acagtctccg gaattactgg cctggtgatc
      541 tctctggctt tgatattgat catgacctct tcaactgagt ttatcaggca gtcctcttat
      601 gagctattct ggtacacaca ccatatcttc atcttcctct tcatcagtct ggccatccac
      661 ggaggaggtc gcatcattcg aggtcaaact ccagagagtc tccggctgca caatgtcacc
      721 ttctgcagag accacttcga cgaatggcag gaagctgcct cgtgccctgt acctcaattt
      781 tctggcaagg agccgtcggc ctggaaatgg actttgggcc ctgtggtctt gtatgcgtgt
      841 gaaataataa ttaggttctg gagatctcac caagaagttg tcattaccaa ggtggtgagt
      901 cacccatctg cagtcctgga acttcacatg aagaagcgtg acttcaagat ggcgcccgga
      961 cagtacatct ttatccagtg cccatccatc tccccgctgg agtggcaccc cttcactctc
     1021 acgtctgctc cccaggagga cttcttcagt gtacacatcc gagcctcagg agactggaca
     1081 gaggcgttac tgaaggcatt tggagcagag ggacaggctc ccagtgagct ctgtagcatg
     1141 ccgagactgg cagtggacgg gcccttcgga ggctctctgg cagatgtatt tcactaccct
     1201 gtgagcgtgt gcattgcaac aggaattgga gtcaccccct tcgcctctct tctgaagtct
     1261 gtgtggtata agtgttgtga atcacagagt ctgcctggac tgagcaaggt gtacttctac
     1321 tggatctgcc gggatgctgc agcctttgag tggtttgccg atctgttact ttcactggaa
     1381 acacagatga gtgaacaagg gaaggctcat ttgctgagtt accacatata tctcactggc
     1441 tgggatgaat accaggcaat tcacatagct ttacactggg atgaaagtct ggatgtgatt
     1501 acaggcttaa agcagaagac cttctatggg cgacccaact ggaatgagga attcaagcag
     1561 attgcctaca atcaccctag cagcagcatt ggcgtgttct tctgtggacc caaagccatg
     1621 tcaaagactc ttcaaaagat gtgccgtttg tactcatcct cagatcctag gggcgttcat
     1681 ttctattaca acaaggaaaa cttctag
//
LOCUS       NM_001001397             927 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus olfactory receptor family 12 subfamily D member 2
            (Or12d2), mRNA.
ACCESSION   NM_001001397 XM_227937
VERSION     NM_001001397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX883052.1.
            
            On Aug 30, 2004 this sequence version replaced XM_227937.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This record was generated from the set of rat
            olfactory receptors mined from Rnor3.1 assembly (NCBI Build 2.1).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..927
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="olfactory receptor family 12 subfamily D member 2"
                     /db_xref="GeneID:294190"
                     /db_xref="RGD:1334001"
     CDS             1..927
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="olfactory receptor 15; olfactory receptor Olr1735;
                     olfactory receptor gene Olr1735; olfactory receptor 1735"
                     /codon_start=1
                     /product="olfactory receptor family 12 subfamily D member
                     2"
                     /protein_id="NP_001001397.1"
                     /db_xref="GeneID:294190"
                     /db_xref="RGD:1334001"
                     /translation="MSNQTSVTEFLLLGVTDIQELNPILFVIFFTIYFVNITGNGAIL
                     MIVILDPRLHSPMYFFLGNLACLDICFSTVTVPKMLENLLSTSKAISFLGCITQLHFF
                     HFLGSTEALLLPVMAFDRFVAICRPLHYSVIMNRQLCSHMTVTIWIMGFLHALLHSVM
                     TSRLSFCGPNHVHHFFCDIKPLLDLACGNTELNLWLLNTVTGTIALTPFFLTFLSYFY
                     IITYLFLKTHSCSMLHKALSTCASHFMVVILLYVPVLFNYIRPASSSALDQERIIAIM
                     YSVVTPALNPLIYTLRNKEVRNALNKKVRRWL"
     misc_feature    67..879
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="olfactory receptor subfamily 12D and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR12D-like; cd15915"
                     /db_xref="CDD:320581"
     misc_feature    67..879
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="olfactory receptor subfamily 12D and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR12D-like; cd15915"
                     /db_xref="CDD:320581"
     misc_feature    70..150
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320581"
     misc_feature    70..150
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320581"
     misc_feature    169..249
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320581"
     misc_feature    169..249
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320581"
     misc_feature    order(235..237,244..249,283..300,304..309,316..318,
                     451..453,457..471,577..579,586..594,598..606,610..615,
                     751..753,760..765,769..774,781..783,799..804,808..816,
                     823..825,832..837)
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320581"
     misc_feature    order(235..237,244..249,283..300,304..309,316..318,
                     451..453,457..471,577..579,586..594,598..606,610..615,
                     751..753,760..765,769..774,781..783,799..804,808..816,
                     823..825,832..837)
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320581"
     misc_feature    283..375
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320581"
     misc_feature    283..375
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320581"
     misc_feature    412..477
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320581"
     misc_feature    412..477
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320581"
     misc_feature    577..669
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320581"
     misc_feature    577..669
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320581"
     misc_feature    691..783
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320581"
     misc_feature    691..783
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320581"
     misc_feature    802..879
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320581"
     misc_feature    802..879
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320581"
     exon            1..927
                     /gene="Or12d2"
                     /gene_synonym="Olr1735; Or15;
                     ratchr20-1349773-1350699_ORF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccaatc aaacctcagt cactgaattt ctcctcctag gagtgacaga catacaagaa
       61 ttaaacccta ttctctttgt gattttcttc accatctact ttgtcaatat aactgggaat
      121 ggagccatcc tgatgattgt catcttggat ccaaggctcc actcacctat gtatttcttc
      181 ctgggaaacc tagcatgtct agatatctgc ttctccactg tgacagtgcc aaagatgttg
      241 gagaacctcc tctccacaag caaagcaatt tccttcctgg gatgcataac tcagcttcat
      301 ttcttccact tcctgggtag cactgaggcc ctgctgctgc cagtgatggc atttgaccgc
      361 tttgtggcta tctgcagacc actccactat tctgtcatca tgaatcgcca gctctgtagt
      421 cacatgactg tgactatctg gatcatgggc ttcttacatg ccctgcttca ctctgtaatg
      481 acatctcgtc tgagcttctg tggtcccaat catgtccatc atttcttctg tgatattaag
      541 ccattgctgg atctggcctg tggaaacact gagctcaacc tttggttgct caatacagtc
      601 acaggcacca ttgccctcac tccctttttt ctgacatttc tctcctattt ctacatcatc
      661 acttatcttt tcctcaagac ccattcctgc agcatgctcc acaaagcact gtcaacttgt
      721 gcctctcact tcatggttgt tattctgctc tacgttcctg ttctctttaa ctacatccgt
      781 cctgcctcaa gcagtgctct ggatcaggag cgaatcattg ccatcatgta cagtgtcgtc
      841 actcctgctc tcaatccact catctacacc ttaagaaaca aagaagtgag gaatgcatta
      901 aataagaagg tgaggagatg gctctga
//
LOCUS       NM_001107191            1775 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 37
            (Zbtb37), mRNA.
ACCESSION   NM_001107191 XM_001073910 XM_222803
VERSION     NM_001107191.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1775)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073910.1, XM_222803.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..1775
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="zinc finger and BTB domain containing 37"
                     /db_xref="GeneID:304918"
                     /db_xref="RGD:1308731"
     exon            1..36
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /inference="alignment:Splign:2.1.0"
     exon            37..232
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    216..218
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="upstream in-frame stop codon"
     exon            233..1189
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1775
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     37"
                     /protein_id="NP_001100661.1"
                     /db_xref="GeneID:304918"
                     /db_xref="RGD:1308731"
                     /translation="MTMEKSGNIQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQA
                     FRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTGRICLQLADII
                     SYLTAASFLQMQHIIDKCTQILEGIHFKINVAEVEAELSQTRTKHPERPPESHRVTPN
                     LTRSLSPRHNASKGNWRGQVSAVLDIRELSPPEESTSPQIIEQSSDVEGREPILRINR
                     AGQWYVETGIADQGPQSGDEVRVLGAVHIKTENLEEWLGPENQPSGEDGSSAEEVAAM
                     VIDTTGHGSVGQESYTLGSSGAKVARPTSSEVDRFSPSGSVVSMTERHRARSESPGRM
                     DEPKQLSSQVEESAMMGVSAYVEYLREQEVSERWFRYNPRLTCIYCAKSFNQKGSLDR
                     HMRLHMGITPFVCRMCGKKYTRKDQLEYHIRKHTGNKPFHCHVCGKSFPFQAILNQHF
                     RKNHPGCIPLEGPHSISPETTVTSRQAEEGSPSHEETVAPGESAQGSVSTTGPD"
     misc_feature    285..653
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 37 (ZBTB37); Region:
                     BTB_POZ_ZBTB37; cd18222"
                     /db_xref="CDD:349531"
     misc_feature    285..653
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 37 (ZBTB37); Region:
                     BTB_POZ_ZBTB37; cd18222"
                     /db_xref="CDD:349531"
     misc_feature    1389..1451
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1389..1451
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1404..1406,1410..1412,1416..1418,1422..1427,
                     1434..1439,1446..1448,1488..1490,1494..1496,1506..1511,
                     1518..1523,1530..1532,1572..1574,1578..1580,1584..1586,
                     1590..1595,1602..1607)
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1404..1406,1410..1412,1416..1418,1422..1427,
                     1434..1439,1446..1448,1488..1490,1494..1496,1506..1511,
                     1518..1523,1530..1532,1572..1574,1578..1580,1584..1586,
                     1590..1595,1602..1607)
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1425..1502
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1425..1502
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1467..1535
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1467..1535
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1473..1535
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1473..1535
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1512..1580
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1512..1580
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1557..1613
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1557..1613
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1190..1289
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1775
                     /gene="Zbtb37"
                     /gene_synonym="RGD1308731"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccggccc attccggccc atttccaccc ccggagctct cgccccttca gcgccgacgc
       61 tagagaaaga ctttactcca ggggcttcct cctcactggg gaattgctgg aaagagcaaa
      121 caaaaaggtg ctggtgtagg ctccaaaata aacatctgaa ttcgtgatgg catcgaccga
      181 ggctcttaat ggattaaaag tttcaaaaca aacaataacg ctttggaaaa agggttgaac
      241 gtctgcctgt actttcaggc atgaccatgg agaaaagtgg aaacatacaa ctggagatcc
      301 ctgacttcag caactctgtt ctgagccatc tcaaccagct acgaatgcaa ggccgtctct
      361 gtgatattgt ggtcaatgtg caaggacagg ctttccgggc tcacaaagta gtgctggctg
      421 ccagctcccc ttatttccgg gatcacatgt ccttgaatga aatgagtact gtgtccattt
      481 ctgtcatcaa gaaccctact gtttttgaac agcttctttc tttctgttac acagggcgga
      541 tatgcctgca actagcagat atcatcagct acctaacagc tgctagtttt ctgcagatgc
      601 agcatattat agacaaatgc acacagatcc tagagggcat tcactttaaa attaatgtgg
      661 ctgaggttga agcagaatta agtcaaacaa ggacaaagca tccagagaga cctccagagt
      721 ctcacagggt aacaccgaat ctaacccgct cacttagtcc acgccataat gcctcaaagg
      781 gaaactggag aggacaagtc agtgccgtgc tggatatcag agagctcagt cctcccgagg
      841 agtccaccag tcctcagata attgaacaga gttctgatgt agagggccgg gagcccattc
      901 tccgaattaa cagagcagga cagtggtatg tggaaacagg gatagcagac caggggcccc
      961 agagtggtga tgaagtcagg gttcttggag cagtgcacat caaaactgaa aatctggagg
     1021 agtggcttgg gccggagaac cagccttctg gagaagatgg cagtagtgcc gaggaggtcg
     1081 ctgccatggt gattgacacc acaggccatg ggtctgtagg gcaagaaagc tacactttag
     1141 ggtcttcggg agccaaggta gctcggccaa ccagcagtga ggtcgacaga tttagtccct
     1201 ccggcagtgt tgtttccatg acagagagac acagagccag aagtgagtct cctgggagaa
     1261 tggatgagcc taagcagctt agctcccagg tagaagagtc agcgatgatg ggagtaagcg
     1321 cctatgtgga gtatctccga gaacaagaag tatctgaacg atggttccgg tataatcccc
     1381 gcctcacctg catctactgt gccaaatctt tcaaccaaaa gggaagtctg gaccgccaca
     1441 tgcgcctgca tatgggaatc acaccatttg tctgccgcat gtgtgggaaa aagtataccc
     1501 ggaaagatca gctggaatat cacatccgca agcacacagg caacaagccc tttcactgtc
     1561 atgtttgtgg caaaagtttc cccttccagg ccatcttgaa tcaacacttt cgaaaaaacc
     1621 accctggttg tatacctctg gaagggcctc atagcatttc tcctgagact actgtcacat
     1681 ctcggcaagc tgaagaaggg tcaccttcac acgaagaaac agttgctcct ggagaatctg
     1741 ctcagggctc agtttctact actgggccag attga
//
LOCUS       NM_001135800             615 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus cardiotrophin 2 (Ctf2), mRNA.
ACCESSION   NM_001135800 XM_001080300 XM_219355
VERSION     NM_001135800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   Derouet,D., Rousseau,F., Alfonsi,F., Froger,J., Hermann,J.,
            Barbier,F., Perret,D., Diveu,C., Guillet,C., Preisser,L.,
            Dumont,A., Barbado,M., Morel,A., deLapeyriere,O., Gascan,H. and
            Chevalier,S.
  TITLE     Neuropoietin, a new IL-6-related cytokine signaling through the
            ciliary neurotrophic factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 101 (14), 4827-4832 (2004)
   PUBMED   15051883
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AY518205.1.
            
            On or before Oct 16, 2008 this sequence version replaced
            XM_219355.3, XM_001080300.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..615
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /note="cardiotrophin 2"
                     /db_xref="GeneID:293515"
                     /db_xref="RGD:1308254"
     CDS             1..615
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /note="neuropoietin; cardiotrophin 2, pseudogene"
                     /codon_start=1
                     /product="cardiotrophin-2 precursor"
                     /protein_id="NP_001129272.1"
                     /db_xref="GeneID:293515"
                     /db_xref="RGD:1308254"
                     /translation="MYCLLAAPLCLLSLLLSPLSPAAPISPSEPIGQAYSLALYMQKN
                     TSALLQTYLQYQGSPFSDPGFSAPELQLSTLPSAAVSFKTWHAMGDAERLRQAQGAFL
                     ALTQHLQLVGDDQSDLNPGSPILLAQLGAARLRAQGLLGNMVTIMTALGLPVPPEEDT
                     LGIVPFGASAFERKCRGYIVTREYGHWTDRAVRDLALLKAKYPA"
     sig_peptide     1..66
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <121..606
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /note="LIF / OSM family; Region: LIF_OSM; cl21565"
                     /db_xref="CDD:419736"
     misc_feature    <121..606
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /note="LIF / OSM family; Region: LIF_OSM; cl21565"
                     /db_xref="CDD:419736"
     exon            1..16
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            17..156
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /inference="alignment:Splign:2.1.0"
     exon            157..615
                     /gene="Ctf2"
                     /gene_synonym="Ctf2p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtactgcc tgctggcagc tcccctctgc ctactgagcc tgctactgtc acccctcagt
       61 cctgcggccc ccatctcccc atcagaaccc atcggtcaag cctatagcct ggccctctac
      121 atgcagaaga acacatcagc attgctgcag acctatctcc agtaccaggg cagccccttc
      181 agtgaccctg gcttctcagc tcctgagctc cagctcagca ccctgccttc cgcagctgtc
      241 tccttcaaga cctggcatgc gatgggcgat gcagagcggc taagacaagc ccagggagcc
      301 ttcctggcct tgacccagca cctccagctc gtgggggacg accagagtga cctgaatcct
      361 ggcagtccta tcctgctggc ccagctagga gcagcaagac tcagggccca aggcctactg
      421 ggcaacatgg tgactatcat gactgctctg gggctgcccg tccctccaga agaggatact
      481 ctgggtatag tccctttcgg ggcctcagcc tttgagagga aatgccgagg ctacatagtg
      541 acccgggaat atggtcactg gacagaccgg gctgtgaggg acttggctct actcaaggcc
      601 aagtacccag catag
//
LOCUS       NM_173310               1701 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 15 (Chst15), mRNA.
ACCESSION   NM_173310
VERSION     NM_173310.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Karumbaiah,L., Anand,S., Thazhath,R., Zhong,Y., McKeon,R.J. and
            Bellamkonda,R.V.
  TITLE     Targeted downregulation of N-acetylgalactosamine 4-sulfate
            6-O-sulfotransferase significantly mitigates chondroitin sulfate
            proteoglycan-mediated inhibition
  JOURNAL   Glia 59 (6), 981-996 (2011)
   PUBMED   21456043
  REMARK    GeneRIF: Downregulation of N-acetylgalactosamine 4-sulfate
            6-O-sulfotransferase (CS-E) via siRNA targeting of GalNAc4S6ST
            mitigates chondroitin sulfate proteoglycan-mediated inhibition of
            neurons, potentially offering an intervention strategy for brain
            injury.
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Ohtake,S., Ito,Y., Fukuta,M. and Habuchi,O.
  TITLE     Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is
            related to human B cell recombination activating gene-associated
            gene
  JOURNAL   J Biol Chem 276 (47), 43894-43900 (2001)
   PUBMED   11572857
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB086953.1.
            
            On Aug 12, 2007 this sequence version replaced NM_173310.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086953.1, SRR8487230.151441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="carbohydrate sulfotransferase 15"
                     /db_xref="GeneID:286974"
                     /db_xref="RGD:628881"
     exon            1..561
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /EC_number="2.8.2.33"
                     /note="B cell RAG associated protein;
                     N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase;
                     carbohydrate (N-acetylgalactosamine 4-sulfate 6-O)
                     sulfotransferase 15"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 15"
                     /protein_id="NP_775432.3"
                     /db_xref="GeneID:286974"
                     /db_xref="RGD:628881"
                     /translation="MRHCINCCIQLFPEDAHKQQVACQGGPHHSHQACPSCKGEDKIL
                     FRVDSKQMNLLAVLEVRTEGNENWGGFLRFRKGKRCSLVFGLIIMTLVMASYILSGAH
                     QELLISSPFHYGGFPSNPSVMDSESPSDVKEHHYQPSVNNISYVKDYPNIKLIIDSIA
                     ARNEFTTRQLPDLQDLKRQELHMFSVIPNKFLPTSKSPCWYEEFSGRNTTDPYLTNSY
                     VLYSKRFRSTFDTLRKAFWGHLSHVHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLH
                     PEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQAASAE
                     QTSKMNRIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPEAKLLVMLR
                     DPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPV
                     RLQVGLYAVYLLDWLTVFSKEQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEAL
                     MTKSPASNTRRPEDRSLGPMWPITQKILRDFYGPFNTRLAQVLDDEAFAWKTT"
     misc_feature    256..318
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHI9.1);
                     transmembrane region"
     misc_feature    772..>1530
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
     misc_feature    772..>1530
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
     misc_feature    1105..1107
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CHI9.1); glycosylation site"
     exon            562..901
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1048
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1205
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1362
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1510
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaaggtct ctaccatgag gcactgcatt aattgctgca tacagctgtt ccccgaagac
       61 gcacacaaac agcaggttgc ctgccaagga ggcccccatc acagtcatca ggcgtgcccc
      121 agttgcaaag gagaagacaa aattctgttc cgggtggaca gtaagcagat gaacttgctt
      181 gctgttctcg aagtgaggac tgagggcaac gaaaactggg gcgggttttt gcgcttcagg
      241 aaagggaagc gatgtagcct ggtctttgga ttgataataa tgaccttggt gatggcttct
      301 tacatccttt ccggggctca tcaggaactt ctaatttcat cccctttcca ttatgggggc
      361 tttcccagca accccagcgt gatggacagt gagagcccta gtgatgtgaa agagcatcac
      421 taccagcctt cggtaaataa catctcctat gtgaaggatt atcccaacat taaactgatt
      481 attgacagca tcgctgccag gaatgagttc acaaccaggc agctcccgga cttacaagat
      541 ctcaagagac aagagttgca catgttttct gtgatcccca ataaattcct tccgactagc
      601 aagagccctt gttggtatga ggaattctcc ggcaggaaca ccactgaccc ctacctgacc
      661 aattcctacg tgctctactc caagcgcttc cgctctacct ttgacactct gcgaaaggct
      721 ttctggggcc acctgtccca tgtgcatggc aagcatttcc gcctgcgctg cctgccacac
      781 ttctacatca ttgggcagcc caagtgcgga accactgacc tctatgaccg ccttcggctg
      841 catccagaag tgaaattctc agccatcaag gagccccact ggtggacccg gaagcgcttt
      901 ggaattgtcc gcctgaggga tgggctacga gaccgctacc ctgtggaaga ttacctggac
      961 ctctttgact tggctgcaca ccagatccat caaggactgc aggctgcctc tgcagagcag
     1021 acgagcaaga tgaataggat cattatcgga gaggccagcg cctctacaat gtgggataac
     1081 aatgcctgga ccttcttcta tgacaacagc acagacggcg agccaccgtt cctgacccaa
     1141 gacttcatcc atgcctttca gcctgaagcc aagctccttg tcatgctcag ggatcccgtg
     1201 gagaggttgt actcagacta tctctacttt gcaagttcaa ataaatccgc cgatgacttc
     1261 cacgagaagg tgacggaggc tctgcagctg tttgaaaatt gcatgctgga ttattcactg
     1321 cgcgcctgcg tctacaacaa caccctgaac aatgccatgc ccgtgaggct ccaggtcggt
     1381 ctgtatgctg tgtatctcct ggactggctc actgtcttca gtaaggagca gttcctcatt
     1441 ctacgtctgg aagaccatgc atccaatgtc aagtacacca tgcacaaggt cttccagttt
     1501 ctaaacctgg ggcctctaag tgagaagcaa gaagctttga tgaccaagag ccccgcgtcc
     1561 aacacacggc gtcctgagga tcgtagtctg ggacccatgt ggccgatcac tcagaagatc
     1621 ctgcgggact tctacgggcc tttcaacaca aggctggcac aggtcctgga tgatgaggcg
     1681 tttgcgtgga agacgacgtg a
//
LOCUS       NM_023996                930 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus taste receptor, type 2, member 114 (Tas2r114),
            mRNA.
ACCESSION   NM_023996
VERSION     NM_023996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227143.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF227143.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..930
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="taste receptor, type 2, member 114"
                     /db_xref="GeneID:78982"
                     /db_xref="RGD:620737"
     CDS             1..930
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="T2R114; taste receptor type 2 member 5; taste
                     receptor T2R5"
                     /codon_start=1
                     /product="taste receptor type 2 member 114"
                     /protein_id="NP_076486.1"
                     /db_xref="GeneID:78982"
                     /db_xref="RGD:620737"
                     /translation="MLGAMEGVLLSVATSEALLGIVGNTFIALVNCMDCTRNKNLYNI
                     GFILTGLAISRICLVWILITEAYIKIFSPQLLSPINIIELISYLWIITSQLNVWFATS
                     LSIFYFLKIANFSHHIFLWLKRRINIVFAFLIGCLLMSWLFSFPVVVKMVKDKKMLYI
                     NSSWQIHMKKSELIINYVFTNGGVFLLFIIMLIVCFLLIISLWRHSKWMQSNESGFRD
                     LNTEVHVKTIKVLLSFIILFILHLIGITINVICLLVPENNLLFVFGLTIAFLYPCCHS
                     LILILANSRLKRCFVRILQQLMCSEEGKEFRNT"
     misc_feature    19..873
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    19..873
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="mammalian taste receptor 2, subtype 10, member of
                     the seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_TAS2R10; cd15021"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..99
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320149"
     misc_feature    22..84
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    130..192
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    133..207
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    133..207
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    247..315
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320149"
     misc_feature    262..324
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    382..444
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    391..441
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    391..441
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320149"
     misc_feature    481..483
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JKT8.1); glycosylation site"
     misc_feature    517..588
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    517..588
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320149"
     misc_feature    547..609
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    661..738
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    661..738
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320149"
     misc_feature    700..762
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     misc_feature    772..849
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    772..849
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320149"
     misc_feature    778..840
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKT8.1);
                     transmembrane region"
     exon            1..930
                     /gene="Tas2r114"
                     /gene_synonym="T2R5; Tas2r5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgggtg caatggaagg tgtcctcctt tcagttgcaa ctagtgaggc tttgcttggc
       61 attgtaggga acacattcat tgcacttgtg aactgcatgg actgtaccag gaacaagaat
      121 ctctataata ttggcttcat tctcactggc ttggcaattt ccagaatctg cctcgtgtgg
      181 atcttaatca cagaggcata cataaaaata ttctctccac agttgctgtc tcctatcaac
      241 ataattgaac tcatcagtta tctatggata attaccagtc aattgaatgt ttggtttgct
      301 accagcctca gtatctttta tttcctcaag atagcaaatt tttcccacca catatttctc
      361 tggttaaaaa gaagaattaa tatagttttt gccttcctga tagggtgctt acttatgtca
      421 tggctatttt ctttcccagt agttgtgaag atggttaaag ataaaaaaat gctgtatata
      481 aactcatctt ggcaaatcca catgaagaaa agtgagttaa tcattaacta tgttttcacc
      541 aatgggggag tatttttact ttttataata atgttaattg tatgttttct cttaattatt
      601 tccctttgga gacacagcaa gtggatgcaa tcaaatgaat caggattcag agatctcaac
      661 acagaagttc atgtgaaaac aataaaagtt ttattatctt ttattatcct ttttatattg
      721 catttaattg gtattaccat caatgtcatt tgtctgttag tcccagaaaa taacttgtta
      781 ttcgtgtttg gtttgacgat tgcattcctc tatccctgct gccactcact tatcctaatt
      841 ctagcaaaca gccggctgaa acgatgcttt gtaaggatac tgcaacaatt aatgtgctct
      901 gaggaaggaa aagaattcag aaacacatga
//
LOCUS       NM_001004097             741 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trypsin 10 (Try10), mRNA.
ACCESSION   NM_001004097 XM_579123
VERSION     NM_001004097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 741)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000327.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579123.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000327.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760434,
                                           SAMN06621351 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..741
                     /gene="Try10"
                     /note="trypsin 10"
                     /db_xref="GeneID:408247"
                     /db_xref="RGD:1359400"
     CDS             1..741
                     /gene="Try10"
                     /function="serine protease"
                     /codon_start=1
                     /product="trypsin 10 precursor"
                     /protein_id="NP_001004097.1"
                     /db_xref="GeneID:408247"
                     /db_xref="RGD:1359400"
                     /translation="MNAVLILALVGAAVAFPAADDDKIVGGYTCQENSVPYQVSLNSG
                     YHFCGGSLINEQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFIRK
                     TLNNDIMLIKLSSPVKLNSRVATVALPSSCAPAGTQCLISGWGNTLSFGVNEPDLLQC
                     LDAPLLPQADCEASYPGKITDNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGY
                     GCALPDNPGVYTKVCNYVDWIQDTIAAN"
     sig_peptide     1..60
                     /gene="Try10"
     mat_peptide     61..738
                     /gene="Try10"
                     /product="trypsin 10"
     misc_feature    70..726
                     /gene="Try10"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...; Region:
                     Tryp_SPc; cd00190"
                     /db_xref="CDD:238113"
     misc_feature    70..726
                     /gene="Try10"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...; Region:
                     Tryp_SPc; cd00190"
                     /db_xref="CDD:238113"
     misc_feature    70..72
                     /gene="Try10"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     misc_feature    70..72
                     /gene="Try10"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     misc_feature    order(187..189,319..321,598..600)
                     /gene="Try10"
                     /note="active site"
                     /db_xref="CDD:238113"
     misc_feature    order(187..189,319..321,598..600)
                     /gene="Try10"
                     /note="active site"
                     /db_xref="CDD:238113"
     misc_feature    order(580..582,643..645,649..651)
                     /gene="Try10"
                     /note="substrate binding sites [chemical binding]; other
                     site"
                     /db_xref="CDD:238113"
     misc_feature    order(580..582,643..645,649..651)
                     /gene="Try10"
                     /note="substrate binding sites [chemical binding]; other
                     site"
                     /db_xref="CDD:238113"
     exon            1..40
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            41..200
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            201..454
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            455..591
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
     exon            592..741
                     /gene="Try10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatgctg tcctgatcct ggctcttgtg ggagctgctg ttgctttccc tgctgctgat
       61 gatgacaaga ttgttggagg atatacctgc caggagaact ctgtccccta ccaggtgtcc
      121 ctgaactctg gctaccattt ctgtggaggc tccctcatta atgaacaatg ggtggtgtct
      181 gcagctcact gctacaaaag ccgcatccaa gtgagactgg gagagcacaa catcaatgtc
      241 cttgagggca atgagcagtt tgtcaatgct gccaagatca tcaagcaccc taacttcatt
      301 aggaagaccc tgaacaatga catcatgctg atcaagctct cttcccctgt gaaactcaat
      361 tcccgagtgg ccactgtggc tctgcccagc tcctgtgcac ctgcaggcac tcagtgcctc
      421 atttctggct ggggcaacac gctcagcttc ggtgtcaatg aaccagacct gctccagtgc
      481 ctggatgccc cactgctgcc gcaggctgac tgtgaggcct cctaccctgg aaagatcact
      541 gataacatgg tctgtgctgg cttcctagag ggaggcaagg attcctgcca gggtgactct
      601 ggtggccctg tggtctgcaa tggagagctc caaggcattg tctcctgggg ctatggctgt
      661 gccctgccag ataaccctgg tgtgtacacc aaggtctgca actatgtgga ctggattcag
      721 gacacaattg ctgccaacta g
//
LOCUS       NM_012499               8582 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus APC regulator of WNT signaling pathway (Apc),
            mRNA.
ACCESSION   NM_012499
VERSION     NM_012499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8582)
  AUTHORS   Shirakami,Y., Nakanishi,T., Ozawa,N., Ideta,T., Kochi,T.,
            Kubota,M., Sakai,H., Ibuka,T., Tanaka,T. and Shimizu,M.
  TITLE     Inhibitory effects of a selective prostaglandin E2 receptor
            antagonist RQ-15986 on inflammation-related colon tumorigenesis in
            APC-mutant rats
  JOURNAL   PLoS One 16 (5), e0251942 (2021)
   PUBMED   34003864
  REMARK    GeneRIF: Inhibitory effects of a selective prostaglandin E2
            receptor antagonist RQ-15986 on inflammation-related colon
            tumorigenesis in APC-mutant rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8582)
  AUTHORS   Yuan,B., Wu,W., Zhang,H., Gu,H., Guo,D., Jiang,J. and Wang,X.
  TITLE     Adenomatous polyposis coli as a predictor of environmental
            chemical-induced transgenerational effects related to male
            infertility
  JOURNAL   J Biochem Mol Toxicol 33 (7), e22331 (2019)
   PUBMED   30934153
  REMARK    GeneRIF: the miR-30 family/APC interaction is a potential mechanism
            for the transgenerational effects induced by the environmental
            chemical.
REFERENCE   3  (bases 1 to 8582)
  AUTHORS   Torricelli,F., Nicoli,D., Bellazzi,R., Ciarrocchi,A., Farnetti,E.,
            Mastrofilippo,V., Zamponi,R., La Sala,G.B., Casali,B. and
            Mandato,V.D.
  TITLE     Computational development of a molecular-based approach to improve
            risk stratification of endometrial cancer patients
  JOURNAL   Oncotarget 9 (39), 25517-25528 (2018)
   PUBMED   29876005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8582)
  AUTHORS   Arif,M., Pandey,R., Alam,P., Jiang,S., Sadayappan,S., Paul,A. and
            Ahmed,R.P.H.
  TITLE     MicroRNA-210-mediated proliferation, survival, and angiogenesis
            promote cardiac repair post myocardial infarction in rodents
  JOURNAL   J Mol Med (Berl) 95 (12), 1369-1385 (2017)
   PUBMED   28948298
REFERENCE   5  (bases 1 to 8582)
  AUTHORS   Council,L.N., Shanmugam,C., Suswam,E.A., Katkoori,V.R.,
            Heslin,M.J., Hanna,A., Jhala,N.C., Varambally,S. and Manne,U.
  TITLE     Association between Hepatitis C Virus Infection, p53 Phenotypes,
            and Gene Variants of Adenomatous Polyposis Coli in Hepatocellular
            Carcinomas
  JOURNAL   J Dig Dis Hepatol 2016 (5) (2016)
   PUBMED   28203651
REFERENCE   6  (bases 1 to 8582)
  AUTHORS   Clarke,A.R., Cummings,M.C. and Harrison,D.J.
  TITLE     Interaction between murine germline mutations in p53 and APC
            predisposes to pancreatic neoplasia but not to increased intestinal
            malignancy
  JOURNAL   Oncogene 11 (9), 1913-1920 (1995)
   PUBMED   7478622
REFERENCE   7  (bases 1 to 8582)
  AUTHORS   Kakiuchi,H., Watanabe,M., Ushijima,T., Toyota,M., Imai,K.,
            Weisburger,J.H., Sugimura,T. and Nagao,M.
  TITLE     Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat
            colon tumors induced by
            2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 910-914 (1995)
   PUBMED   7846077
REFERENCE   8  (bases 1 to 8582)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   9  (bases 1 to 8582)
  AUTHORS   Horii,A., Nakatsuru,S., Miyoshi,Y., Ichii,S., Nagase,H., Ando,H.,
            Yanagisawa,A., Tsuchiya,E., Kato,Y. and Nakamura,Y.
  TITLE     Frequent somatic mutations of the APC gene in human pancreatic
            cancer
  JOURNAL   Cancer Res 52 (23), 6696-6698 (1992)
   PUBMED   1423316
REFERENCE   10 (bases 1 to 8582)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D38629.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/N"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC regulator of WNT signaling pathway"
                     /db_xref="GeneID:24205"
                     /db_xref="RGD:2123"
     exon            1..188
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    45..47
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="upstream in-frame stop codon"
     CDS             54..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="adenomatosis polyposis coli; WNT signaling pathway
                     regulator; APC, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="adenomatous polyposis coli protein"
                     /protein_id="NP_036631.1"
                     /db_xref="GeneID:24205"
                     /db_xref="RGD:2123"
                     /translation="MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTELETEASNM
                     KEVLKQLQGSIEDETMTSGQIDLLERLKEFNLDSNFPGVKLRSKMSLRSYGSREGSVS
                     SRSGECSPVPMGSFPRRAFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQL
                     QNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIAR
                     IQQIEKDILRVRQLLQSQAAEAERSSQSKHETASHEAERQLEGQGVAESNLATSGSGQ
                     SSAARVDHETAGVLSSSGTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLA
                     MSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQ
                     PDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCV
                     LMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMHGLTDDHYSVTLRRYAGMALTNLTF
                     GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS
                     VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQT
                     NTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTL
                     WNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANI
                     MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYV
                     FDASRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGI
                     GLSTYHSATENPGTSSKRGLQLSATAAQIAKVMEEVSALHTSQDDRSPASAAELHCVA
                     EERTAARRSSASHTHPNTHNFAKSESSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGYG
                     KRGQMKPSVESYSEDDEGKFCSYGQYPADLAHKIHSANHMDDNGGELDTPINYSLKYS
                     DEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQSRSQNTNFPVYSENTDDKHLKFQ
                     QHFGQQECVSPYRSRGTNGSETNRMGSSHAVNQNVNQSLCQEDDYEDDKPTNYSERYS
                     EEEQHEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISSSQKPSFSFSKTPSVQGT
                     KTEHNSPSSEAASAPSSNAKRQSQLHPSSAQRNGQTPKGTACKVPSINQETMQTYCVE
                     DTPICFSRCSSLSSLSSAEDEIGCDQTTQEADSANTLQIAEIKENDVTRSAQDPASDV
                     PAVSQSTRTKPSRLQASGLASESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETP
                     LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIVSPSDLPDSPGQTMPPSRSKTP
                     PPPPPPQPVQTKREVPKTKVPAAEQREGGPKQTAVSAAVQRVQVLPDADTLLHFATES
                     TPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETEPEQPEESNENQDKEV
                     EKPDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQL
                     PVYKLLPSQSRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELA
                     AGDGVRASVQSGEFEKRDTIPTEGRSTDEAQRGKVSSIAIPDLDGSKAEEGDILAECI
                     NSALPKGRSHKPFRVKKIMDQVQQASMTSSGTNKNQIDTKKKKPTSPVKPMPQNTEYR
                     TRVRKNTDSKVNVNTEETFSDNKDSKKQSLKNNPKDLNDKLPDNEDRVRGGFTFDSPH
                     HYAPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCHTEPSS
                     SQQSARKAQASTKHPVNRGPSKPLLQEQPTFPQSSKDVPDRGAATDEKLQNFAIENTP
                     VCFSRNSSLSSLSDVDQENNNNEETGPVRDAEPANAQGQPGKPQASGYAPKSFHVEDT
                     PVCFSRNSSLSSLSIDSEDDLLRECISSAMPKKRRPSRLKGEGEWQSPRKVGSVLAED
                     LTLDLKDIQRPESEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAACLSRQASSDS
                     DSILSLKSGVSLGSPFHLTPDQEEKPFTSHKGPRILKPGEKSTLEAKKIESENKGIKG
                     GKKVYKSLITGKIRSNSEISSQMKQPLQTNMPSISRGRTMIHIPGVRNSSSSTSPVSK
                     KGPPLKTPASKSPSEGPVATTSPRGTKPAVKSELSPITRQTSHISGSNKGPSRSGSRD
                     STPSRPTQQPLSRPMQSPGRNSISPGRNGISTPNKLSQLPRTSSPSTASTKSSGSGKM
                     SYTSPGRQLSQQNLSKQTGLSKNASSIPRSESASKGLNQMNNSNGSNKKVELSRMSST
                     KSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQ
                     TPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYSDGRPSKRHDIARSHSESPSR
                     LPVNRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSVP
                     GPRQMKENQVPTKGTWRKIKESEISPTNTVSQTTSSGAASGAESKTLIYQMAPAVSRT
                     EDVWVRIEDCPINNPRSGRSPTGNTPPVIDSISEKGNPSIKDSKDTQGKQSVGSGSPV
                     QTVGLENRLNSFIQVEAPEQKGTETKAGQGSPAPVAETGETCMAERTPFSSSSSSKHS
                     SPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVGSSTKKRDSKTDSTESSGAQ
                     SPKRHSGSYLVTSV"
     misc_feature    57..59
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); acetylation site"
     misc_feature    63..218
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     Region: APC_N_CC; pfam16689"
                     /db_xref="CDD:435517"
     misc_feature    63..218
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     Region: APC_N_CC; pfam16689"
                     /db_xref="CDD:435517"
     misc_feature    <117..>986
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <117..>986
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    366..368
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    378..380
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    426..668
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; Region: Suppressor_APC; pfam11414"
                     /db_xref="CDD:463275"
     misc_feature    426..668
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; Region: Suppressor_APC; pfam11414"
                     /db_xref="CDD:463275"
     misc_feature    765..965
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1065..1223
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1065..1223
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1224..1445
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Adenomatous polyposis coli (APC) repeat; Region:
                     APC_rep; pfam18797"
                     /db_xref="CDD:465870"
     misc_feature    1224..1445
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Adenomatous polyposis coli (APC) repeat; Region:
                     APC_rep; pfam18797"
                     /db_xref="CDD:465870"
     misc_feature    1404..1532
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 1"
     misc_feature    1422..1577
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1422..1577
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1440..1571
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1440..1571
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    order(1542..1544,1554..1556,1566..1568,1671..1673,
                     1683..1685,1695..1697,1803..1805,1815..1817,1827..1829)
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    order(1542..1544,1554..1556,1566..1568,1671..1673,
                     1683..1685,1695..1697,1803..1805,1815..1817,1827..1829)
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    1560..1688
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 2"
     misc_feature    1581..1706
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1581..1706
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1593..1706
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1593..1706
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1689..1820
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 3"
     misc_feature    1725..1832
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1725..1832
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1821..1961
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 4"
     misc_feature    1854..1979
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1854..1979
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1962..2096
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 5"
     misc_feature    1992..2114
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1992..2114
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    2004..2108
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2004..2108
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2097..2222
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 6"
     misc_feature    2118..2240
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeat; Region: Arm;
                     pfam00514"
                     /db_xref="CDD:425727"
     misc_feature    2118..2240
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo/beta-catenin-like repeat; Region: Arm;
                     pfam00514"
                     /db_xref="CDD:425727"
     misc_feature    2130..2240
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2130..2240
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2223..2348
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: ARM 7"
     misc_feature    2241..3104
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo-associated region on APC; Region:
                     Arm_APC_u3; pfam16629"
                     /db_xref="CDD:435476"
     misc_feature    2241..3104
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Armadillo-associated region on APC; Region:
                     Arm_APC_u3; pfam16629"
                     /db_xref="CDD:435476"
     misc_feature    2277..2279
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    2289..2291
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    2385..2387
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    2535..2684
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2769..2771
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    2814..2879
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2919..3017
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3006..3008
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    3105..3554
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Interaction with catenins.
                     /evidence=ECO:0000250|UniProtKB:P25054"
     misc_feature    3153..3452
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; Region: APC_u5; pfam16630"
                     /db_xref="CDD:406923"
     misc_feature    3153..3452
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; Region: APC_u5; pfam16630"
                     /db_xref="CDD:406923"
     misc_feature    3159..3161
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    3171..3173
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    3225..3287
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3327..3551
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3615..3800
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3813..>3866
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC repeat; Region: APC_r; pfam05923"
                     /db_xref="CDD:461781"
     misc_feature    3813..>3866
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC repeat; Region: APC_r; pfam05923"
                     /db_xref="CDD:461781"
     misc_feature    3891..4148
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; Region: APC_u9; pfam16633"
                     /db_xref="CDD:435478"
     misc_feature    3891..4148
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; Region: APC_u9; pfam16633"
                     /db_xref="CDD:435478"
     misc_feature    3969..4172
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4122..4124
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4155..4157
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4197..4199
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4218..4220
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4227..4229
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4245..4475
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4356..4358
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4626..4757
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4746..4748
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    4803..4880
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4956..5027
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC repeat; Region: APC_r; pfam05923"
                     /db_xref="CDD:461781"
     misc_feature    4956..5027
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC repeat; Region: APC_r; pfam05923"
                     /db_xref="CDD:461781"
     misc_feature    5031..5189
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; Region: APC_u13; pfam16634"
                     /db_xref="CDD:406927"
     misc_feature    5031..5189
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; Region: APC_u13; pfam16634"
                     /db_xref="CDD:406927"
     misc_feature    5034..5186
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    5193..5258
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="SAMP Motif; Region: SAMP; pfam05924"
                     /db_xref="CDD:461782"
     misc_feature    5193..5258
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="SAMP Motif; Region: SAMP; pfam05924"
                     /db_xref="CDD:461782"
     misc_feature    5193..5195
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5283..5564
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; Region: APC_u14; pfam16635"
                     /db_xref="CDD:435479"
     misc_feature    5283..5564
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; Region: APC_u14; pfam16635"
                     /db_xref="CDD:435479"
     misc_feature    5295..5903
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    5367..5369
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5628..5630
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5634..5636
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5637..5639
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5643..5726
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Highly charged"
     misc_feature    5664..5888
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; Region: APC_u15; pfam16636"
                     /db_xref="CDD:435480"
     misc_feature    5664..5888
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; Region: APC_u15; pfam16636"
                     /db_xref="CDD:435480"
     misc_feature    5940..6083
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    5958..5960
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    5964..5966
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6147..6206
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="SAMP Motif; Region: SAMP; pfam05924"
                     /db_xref="CDD:461782"
     misc_feature    6147..6206
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="SAMP Motif; Region: SAMP; pfam05924"
                     /db_xref="CDD:461782"
     misc_feature    6153..6227
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Interaction with AXIN1.
                     /evidence=ECO:0000250|UniProtKB:P25054"
     misc_feature    6180..6254
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    6312..6314
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6327..6329
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6426..6428
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61315; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6438..6440
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6441..6443
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6447..6449
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6495..6572
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    6504..6506
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6552..8075
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Basic region.
                     /evidence=ECO:0000250|UniProtKB:P25054"
     misc_feature    6720..7757
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC basic domain; Region: APC_basic; pfam05956"
                     /db_xref="CDD:428690"
     misc_feature    6720..7757
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="APC basic domain; Region: APC_basic; pfam05956"
                     /db_xref="CDD:428690"
     misc_feature    6753..7976
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    6831..6833
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6861..6863
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    6900..6902
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    7470..7472
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    7476..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Interaction with DLG1.
                     /evidence=ECO:0000250|UniProtKB:P25054"
     misc_feature    7656..7658
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    7758..7760
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8043..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    8061..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="EB-1 Binding Domain; Region: EB1_binding;
                     pfam05937"
                     /db_xref="CDD:399141"
     misc_feature    8061..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="EB-1 Binding Domain; Region: EB1_binding;
                     pfam05937"
                     /db_xref="CDD:399141"
     misc_feature    8064..8066
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8073..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Interaction with MAPRE1.
                     /evidence=ECO:0000250|UniProtKB:P25054"
     misc_feature    8073..8075
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8088..8090
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8181..8183
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8220..8222
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8415..8417
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P25054; propagated from
                     UniProtKB/Swiss-Prot (P70478.1); phosphorylation site"
     misc_feature    8457..8468
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: Microtubule tip localization signal"
     misc_feature    8571..8579
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /note="propagated from UniProtKB/Swiss-Prot (P70478.1);
                     Region: PDZ-binding. /evidence=ECO:0000250"
     exon            189..270
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            271..469
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            579..692
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            693..776
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            777..881
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            882..980
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1359
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1455
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1595
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1673
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1790
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2005
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..8582
                     /gene="Apc"
                     /gene_synonym="RATAPC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagtgaat ttcaaaatcc tttttaacct tataggtcca agggtagcca aggatggcag
       61 cagcctcata tgatcagttg ttaaagcaag ttgaggccct gaagatggag aactcaaatc
      121 ttcgacaaga gctcgaagat aattccaatc accttacaga actggaaact gaggcatcta
      181 acatgaagga agtacttaag cagctgcagg gaagtattga agatgagact atgacttccg
      241 gacagattga tttactagag cgccttaaag aatttaactt agatagcaat ttccccggag
      301 tgaaactacg ctcgaaaatg tccctccgat cctatggaag tcgggaagga tctgtatcaa
      361 gccgttcagg agaatgcagt cctgtcccca tggggtcatt cccaagaaga gcatttgtaa
      421 atggaagcag agaaagcact ggatacttag aagagcttga gaaagagaga tcattactcc
      481 ttgctgatct tgacaaagaa gaaaaggaaa aggactggta ttatgctcag cttcagaacc
      541 tcacgaaaag aatagatagc ctgcccttga ctgagaactt ttccttacag acagacatga
      601 caagacggca gctggagtat gaagcacggc agatcagggc cgcaatggag gagcagcttg
      661 gcacctgcca ggacatggag aaacgagcac agcgaagaat agccaggatt cagcaaatag
      721 agaaggacat tcttcgtgta cggcagctct tacagtccca agcggctgaa gcagagaggt
      781 catctcagag caagcatgaa actgcctccc atgaagctga gcggcagctt gaaggtcaag
      841 gagtggcaga aagcaacttg gcaacttctg gtagtggcca gagttcagct gcacgtgtgg
      901 atcatgaaac agccggtgtt ttgagttcta gcggcacaca ctctgctcct cgaaggctga
      961 cgagtcacct gggaacgaag gtggaaatgg tgtattcatt gttgtccatg cttggtactc
     1021 atgataagga cgatatgtca cgaactttgc tagctatgtc tagctcccaa gacagctgta
     1081 tatccatgcg acagtctgga tgtcttcctc tcctcatcca gcttttacat ggcaatgaca
     1141 aagactctgt gttgttggga aattcccggg gcagtaaaga ggctcgggcc agggccagtg
     1201 cagccctcca caacatcatt cactcacagc ctgatgacaa gagaggcagg cgtgaaatcc
     1261 gggtccttca tcttttggaa cagatacgag cttactgcga aacctgttgg gagtggcagg
     1321 aagcccatga acaaggcatg gaccaggaca aaaatccaat gccagctcct gttgagcatc
     1381 agatctgccc tgcggtgtgt gttctgatga aactctcatt tgatgaggag cacagacatg
     1441 cgatgaatga gcttgggggg ctgcaggcta ttgcagagtt actgcaggtg gactgtgaga
     1501 tgcacgggct cactgatgac cactacagtg tcactctacg acggtacgct ggaatggcct
     1561 tgacaaacct gacctttgga gatgttgcca acaaggctac gctgtgttct atgaaaggct
     1621 gcatgagggc actcgtggcc cagttaaaat ccgaaagtga agacttacag caggttattg
     1681 caagtgtttt gcggaatttg tcttggcgag cagatgtaaa tagcaaaaag acgttgagag
     1741 aagttggaag tgtgaaagcg ttgatggaat gtgctttgga agttaaaaag gaatcaactc
     1801 tcaaaagcgt cttgagtgcc ttatggaatc tgtccgcaca ctgcactgag aataaggctg
     1861 acatatgtgc tgtggacggg gcactggcat ttctggttgg caccctcact taccggagcc
     1921 agacaaatac gttagccatc attgaaagtg gaggtgggat attacggaat gtgtccagct
     1981 tgatagctac caacgaagac cacagacaaa tcctaagaga gaacaactgc ctacaaactt
     2041 tattacagca cttgaaatct cacagcttga caatagtcag taatgcatgt ggaactctgt
     2101 ggaatctctc agcgagaaat cctaaagacc aggaggctct gtgggacatg ggggcggtga
     2161 gcatgctcaa gaacctcatt cattccaagc acaaaatgat cgctatgggg agcgcagcag
     2221 ctttaaggaa tctcatggca aacagacctg caaagtataa ggatgccaac atcatgtctc
     2281 ctggctcaag tttgccatcc cttcacgtta ggaaacaaaa agctctagaa gcagaattag
     2341 acgctcagca tttatcagaa acctttgaca atattgacaa tttaagtccc aaggcatctc
     2401 atcgcagtaa gcagagacac aagcagaatc tttatggtga ctatgtcttt gacgccagtc
     2461 gacatgatga caataggtca gacaacttta acactggaaa catgactgtt ctttcaccat
     2521 acttaaatac cacagtattg cccagctctt cttcatcaag gggaagttta gacagttctc
     2581 gttctgagaa agacagaagt ttggagagag aacgaggtat tggcctcagc acttaccatt
     2641 cagcaacaga aaatccggga acctcttcca aacggggttt gcagctctct gccactgcag
     2701 cccagatagc caaagtgatg gaagaagtgt ccgccctcca cacctcccag gacgacagaa
     2761 gccccgcctc tgccgctgag ctccactgtg tggcggagga gaggactgca gcacgaagaa
     2821 gctctgcgtc ccacacacat ccaaacacac acaacttcgc taagtcggaa agctcaaaca
     2881 ggacatgctc catgccttat gccaaggtgg aatataagag atcttcaaat gacagcttaa
     2941 acagtgtcac tagtagtgat ggctatggta aaaggggcca gatgaagccc tcggttgagt
     3001 cctactcaga agatgatgaa ggtaagtttt gcagttatgg gcagtatcct gccgacctag
     3061 cccataagat acacagtgca aatcatatgg atgataatgg tggggagctg gacacaccaa
     3121 taaactacag cctcaagtac tcagatgagc agctgaactc aggaaggcag agcccctcac
     3181 aaaatgaaag gtgggcaaga cccaagcatg tgatagaaga tgaaataaag caaaacgagc
     3241 aaaggcaatc aagaagccag aacaccaatt ttcccgtcta ctctgagaac actgatgaca
     3301 aacacctcaa gttccaacag cattttgggc aacaagagtg cgtttcccca tataggtcca
     3361 ggggaaccaa tggttcagaa acaaatcgaa tgggttctag tcatgcagtt aatcaaaatg
     3421 tgaaccagtc tttgtgtcag gaagacgact atgaagatga caagcctacc aactacagtg
     3481 aacgttattc tgaggaagaa cagcatgaag aagaagagag accgacaaat tacagcataa
     3541 agtataatga agagaaacac catgtggatc agcctattga ttatagtcta aaatatgcca
     3601 ctgacatatc ttcatcccag aagccatcat tttcattctc aaagactcca tcagtacagg
     3661 gcactaaaac tgaacataac tctccaagca gtgaggctgc atctgcacct tcatctaacg
     3721 ccaaaaggca gagtcagctg catccaagtt cagcacaaag aaatggtcag actccaaaag
     3781 ggactgcctg caaagtcccc tccatcaacc aagagacaat gcagacttac tgtgtagaag
     3841 acaccccaat atgtttctca aggtgtagtt ccttatcatc gctatcatca gctgaggatg
     3901 aaataggctg tgatcagaca acacaggagg cagactctgc gaatactctg caaatagcag
     3961 agataaaaga gaatgatgtg acgcggtcag ctcaagaccc tgcgagtgac gtcccagccg
     4021 tgtcccagag tactagaacc aagcccagca gactccaggc ttccggctta gcttcagaat
     4081 ccgccaggca taaagctgtt gagttttctt caggagccaa gtctccctcc aaaagcggtg
     4141 ctcagacacc caaaagtccc ccagaacact atgtccagga gacgcccctt gtattcagca
     4201 ggtgtacttc tgtcagctcc ctggacagtt ttgagagtcg ctccatcgcc agctctgttc
     4261 agagtgagcc atgtagtgga atggtgagtg ggattgtcag ccccagtgac cttccagaca
     4321 gcccagggca gaccatgcca ccaagcagaa gcaagacccc tccccctccc cctcccccac
     4381 agccagtgca gaccaagaga gaggtgccaa aaactaaggt gcctgctgcc gagcagagag
     4441 agggtgggcc taagcagacg gccgtgagtg cggctgtgca gagggtgcag gtcctcccgg
     4501 atgccgacac tctgttacac tttgccacag agagtactcc agatgggttt tcttgttcct
     4561 ctagcctaag tgctctgagt ctggatgagc cctttataca gaaagatgtg gaattaagaa
     4621 taatgcctcc agttcaggaa aacgacaatg ggaatgaaac tgaaccagaa cagcctgaag
     4681 aatctaatga aaaccaggat aaagaggtag aaaagcctga ctctgaaaaa gacttattag
     4741 atgattccga tgatgatgat attgaaatat tagaagaatg tattatttca gccatgccaa
     4801 caaagtcatc acgcaaagcc aaaaagctag cccagactgc ttcaaaatta cctcctcctg
     4861 tggcaaggaa accgagtcag ctgcctgtgt acaaacttct gccgtcacag agcaggctgc
     4921 aggcacaaaa acatgtcagc tttacaccag gggacgatgt gccccgagtg tactgtgtgg
     4981 aagggacgcc tataaacttc tccacagcaa catctctgag tgatctcaca atagaatccc
     5041 ctccgaatga gctggctgct ggagatgggg ttagagcaag tgtacagtca ggtgagtttg
     5101 aaaaacgaga taccattcct acagagggca gaagtacaga tgaggctcag agaggaaaag
     5161 tctcctctat agctatacca gacctggatg gtagcaaagc agaggaagga gatattcttg
     5221 cagaatgcat caattctgcc ctgcccaaag gaagaagcca caagcctttc cgagtgaaaa
     5281 agataatgga ccaagtccaa caggcatcca tgacttcatc cggaactaac aaaaatcaaa
     5341 tagacactaa gaaaaagaag cctacttcac cagtaaagcc catgccacaa aatactgaat
     5401 acagaactcg tgtgagaaag aatacagact caaaagttaa cgtaaatact gaagaaactt
     5461 tctcagacaa taaagactca aagaaacaga gcttaaaaaa caaccccaag gacttgaatg
     5521 acaagctacc ggacaatgag gacagggtcc ggggaggctt tactttcgat tcaccgcatc
     5581 attacgcacc cattgaaggg actccttact gcttctcacg aaatgactct ttgagttctc
     5641 tagattttga tgatgacgat gttgacctct ccagggaaaa ggctgagtta agaaagggca
     5701 aagaaagtaa ggactccgaa gccaaagtta cctgccacac agaaccaagc tcaagccaac
     5761 agtcggctag gaaggcacag gctagtacaa aacatccagt gaacagaggg ccgtctaaac
     5821 cactgctgca ggaacaaccc actttccccc agtcctctaa agacgtacca gacagagggg
     5881 cagcaactga cgaaaaactg cagaattttg ctattgaaaa tacaccggtt tgcttttctc
     5941 gaaattcttc tctgagctcc cttagtgacg ttgaccaaga aaacaacaat aacgaagaaa
     6001 ctggaccagt cagagacgct gagcctgcca acgcgcaagg acagccaggc aagcctcagg
     6061 catctgggta tgcgcccaag tcctttcatg tggaagacac ccctgtgtgc ttctccagaa
     6121 acagctctct cagctctctg agcattgatt ctgaggacga cctgttgcga gagtgcataa
     6181 gctctgctat gccaaaaaag aggaggcctt ccagactcaa gggtgagggt gagtggcaga
     6241 gtcctaggaa agtgggcagc gtgttagccg aagatctgac actcgacttg aaagatatac
     6301 agaggccaga gtcagaacac ggtttatccc ccgattcaga aaatttcgac tggaaagcta
     6361 ttcaggaagg tgcaaactcc atagtaagta gtctgcacca agctgccgcc gccgccgcgt
     6421 gtctgtccag acaagcgtcg tcggactcag actccatcct gtccctgaag tcgggcgtct
     6481 ccctggggtc gccttttcac cttacacctg accaagagga gaagccattc acaagtcata
     6541 aaggcccaag aattctcaaa cctggggaga aaagcacatt agaagcaaaa aaaatagaat
     6601 ccgaaaacaa aggaatcaaa ggtggaaaaa aggtttataa aagcttgatt acaggaaaga
     6661 ttcgatctaa ttcagaaatc tccagccaaa tgaaacaacc ccttcagaca aacatgcctt
     6721 caatctcaag aggcaggaca atgattcaca tcccgggagt tcggaacagc tcctcaagta
     6781 caagccctgt ctctaaaaaa ggcccacccc tcaagactcc agcctctaaa agccccagtg
     6841 aaggtcctgt agctaccact tctcctcgtg gaactaagcc agcagtgaag tcagagctga
     6901 gccctattac caggcaaact tcccacatta gtgggtcaaa taaggggccc tctaggtcag
     6961 ggtctagaga ctccactccc tcgagaccca cacagcagcc attaagtagg ccgatgcagt
     7021 cgccagggcg gaactcgatc tcccccggta gaaatggaat aagcactcct aacaaactct
     7081 ctcagctgcc cagaacatcg tctcccagta ctgcttcgac caagtcctcg gggtcgggga
     7141 aaatgtccta cacatcccca ggccggcagc tgagccagca aaacctcagc aaacaaacag
     7201 gcttgtccaa gaacgccagc agcatcccca gaagtgagtc agcatccaaa ggactgaatc
     7261 agatgaataa cagcaatggg tctaataaaa aggtagaact ttctagaatg tcttcaacta
     7321 agtcaagtgg aagtgaatca gacaggtcag aaagacctgc attagtacgc cagtccactt
     7381 tcatcaaaga agccccaagc ccaaccctaa ggaggaaact ggaggaatct gcctcatttg
     7441 aatccctttc tccatcttct agaccagatt ctcccaccag gtcccaggca cagaccccag
     7501 ttttaagccc ttcccttccc gatatgtctc tgtccacaca tccatctgtt caggcaggtg
     7561 gatggcgcaa gctcccacct aacctcagcc ccactataga gtacagtgac ggaaggccct
     7621 caaagcggca tgatatcgca cgctcccatt ctgaaagtcc gtccagacta ccagtcaacc
     7681 gagcgggaac ctggaagcgt gaacacagca aacattcctc atcccttcct cgagtgagca
     7741 cttggagaag aactggaagc tcatcttcta ttctttctgc ttcttcagag tccagtgaaa
     7801 aagcaaaaag tgaggatgaa aagcatgtga actctgtgcc aggacccaga caaatgaaag
     7861 aaaaccaggt acccacaaaa ggaacatgga ggaaaataaa ggaaagtgaa atttctccca
     7921 caaacacggt ttctcagacc acttcctcag gtgctgccag tggtgctgaa tcaaagactc
     7981 tgatctatca gatggcacct gctgtttcta gaacagagga cgtttgggtg agaattgagg
     8041 actgccccat taacaaccct agatctggaa gatctcccac aggtaacacc cccccagtga
     8101 ttgacagcat ttcagaaaag ggaaatccaa gcattaaaga ttcaaaagac acccaaggaa
     8161 aacaaagtgt gggcagtggc agtcctgtgc aaaccgtggg tctagaaaac cgcctgaact
     8221 cctttattca ggtagaggcc ccggaacaga aaggaactga gactaaagca ggacagggta
     8281 gccctgcccc tgtagcagag actggtgaga cctgcatggc agagcgcacc cctttcagtt
     8341 caagtagctc cagcaagcac agttctccca gtgggacggt cgctgccaga gtgacgcctt
     8401 ttaattacaa cccaagccct aggaaaagca gcgcagacag cacttcagcc cggccatctc
     8461 agatccccac tccggtgggc agcagcacaa agaagagaga ctcgaagact gacagcactg
     8521 aatctagtgg agcccagagt cctaaacgcc attctgggtc ttacctcgtg acgtctgttt
     8581 aa
//
LOCUS       NM_001047954             675 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus YAE1 maturation factor of ABCE1 like 1 (Yae1l1),
            mRNA.
ACCESSION   NM_001047954 XM_001056185 XM_575383
VERSION     NM_001047954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            AY383683.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            XM_575383.2, XM_001056185.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY383683.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..675
                     /gene="Yae1l1"
                     /note="YAE1 maturation factor of ABCE1 like 1"
                     /db_xref="GeneID:500028"
                     /db_xref="RGD:1560448"
     CDS             1..675
                     /gene="Yae1l1"
                     /codon_start=1
                     /product="uncharacterized protein LOC500028"
                     /protein_id="NP_001041419.1"
                     /db_xref="GeneID:500028"
                     /db_xref="RGD:1560448"
                     /translation="MARAMSWFRATPEIPSPGEQDVFDEEADESLLVQREWQDHMRKR
                     VQEGYRDGIDAGKAVTLQQGFNQGYKEGADVILNYGLLRGTLSALLSWCHLHGNSSTL
                     IGKINNLLNAVGQCEECVIKHLKSVTSPPRITDLLDSIEDLDLCHVVPPEKAVEARGD
                     TSADISTDADRSPNGMDCSHPECCRTQEHAHLEKPSLTWILEQTSNLVKQLGISVDIL
                     QHLRQL"
     misc_feature    25..>216
                     /gene="Yae1l1"
                     /note="flagellar assembly protein FliH; Region: fliH;
                     PRK05687"
                     /db_xref="CDD:235562"
     misc_feature    25..>216
                     /gene="Yae1l1"
                     /note="flagellar assembly protein FliH; Region: fliH;
                     PRK05687"
                     /db_xref="CDD:235562"
     misc_feature    142..258
                     /gene="Yae1l1"
                     /note="Essential protein Yae1, N terminal; Region: Yae1_N;
                     pfam09811"
                     /db_xref="CDD:430844"
     misc_feature    142..258
                     /gene="Yae1l1"
                     /note="Essential protein Yae1, N terminal; Region: Yae1_N;
                     pfam09811"
                     /db_xref="CDD:430844"
     exon            1..675
                     /gene="Yae1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctcggg caatgtcttg gtttcgagcg actcccgaga tccccagccc tggagagcag
       61 gacgtgtttg atgaggaagc agacgaatct ctgttagtgc agcgggaatg gcaggatcac
      121 atgaggaaac gagtccaaga aggttacaga gatgggatag atgctggcaa agcagtaacc
      181 cttcaacagg gcttcaatca aggctataaa gagggtgccg atgtcatttt aaactacgga
      241 ctactcaggg gaacattgag cgctttgctt tcctggtgtc accttcatgg taatagttca
      301 acgctgattg gcaagataaa taaccttctg aatgcagttg gccagtgtga agagtgtgtg
      361 atcaaacatc tgaaatcagt tacgtcaccg ccacgcatta cagatttatt ggactccatt
      421 gaggatctgg acctttgtca tgtagtcccg cctgagaaag ctgttgaagc aagaggtgac
      481 actagtgctg acattagcac agatgctgac aggagtccga atgggatgga ttgttcacat
      541 ccagaatgtt gcagaacaca agagcatgcg catttggaaa aaccaagcct cacttggatt
      601 ctggaacaga catccaactt ggtgaaacag ctgggaatat cagtagacat attacagcac
      661 ctgagacaac tgtaa
//
LOCUS       NM_181374               1385 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Sp7 transcription factor (Sp7), transcript
            variant 2, mRNA.
ACCESSION   NM_181374
VERSION     NM_181374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   da Silva Sasso,G.R., Florencio-Silva,R., Sasso-Cerri,E., Gil,C.D.,
            de Jesus Simoes,M. and Cerri,P.S.
  TITLE     Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix
            during the early steps of intramembranous ossification of the
            alveolar process in rat embryos
  JOURNAL   Dev Biol 478, 133-143 (2021)
   PUBMED   34245724
  REMARK    GeneRIF: Spatio-temporal immunolocalization of VEGF-A, Runx2, and
            osterix during the early steps of intramembranous ossification of
            the alveolar process in rat embryos.
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Pokrovskaya,L.A., Nadezhdin,S.V., Zubareva,E.V., Burda,Y.E. and
            Gnezdyukova,E.S.
  TITLE     Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells
            during Culturing in Osteogenic-Conditioned Medium
  JOURNAL   Bull Exp Biol Med 169 (4), 571-575 (2020)
   PUBMED   32910396
  REMARK    GeneRIF: Expression of RUNX2 and Osterix in Rat Mesenchymal Stem
            Cells during Culturing in Osteogenic-Conditioned Medium.
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Xi,Y., Miao,X., Li,Y., Lai,K., Du,X., Jiang,Z., Wang,Y. and Yang,G.
  TITLE     BMP2-mimicking peptide modified with E7 coupling to calcined bovine
            bone enhanced bone regeneration associating with activation of the
            Runx2/SP7 signaling axis
  JOURNAL   J Biomed Mater Res B Appl Biomater 108 (1), 80-93 (2020)
   PUBMED   30912295
  REMARK    GeneRIF: BMP2-mimicking peptide modified with E7 coupling to
            calcined bovine bone enhanced bone regeneration associating with
            activation of the Runx2/SP7 signaling axis.
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Fukuda,M., Yoshizawa,T., Karim,M.F., Sobuz,S.U., Korogi,W.,
            Kobayasi,D., Okanishi,H., Tasaki,M., Ono,K., Sawa,T., Sato,Y.,
            Chirifu,M., Masuda,T., Nakamura,T., Tanoue,H., Nakashima,K.,
            Kobashigawa,Y., Morioka,H., Bober,E., Ohtsuki,S., Yamagata,Y.,
            Ando,Y., Oike,Y., Araki,N., Takeda,S., Mizuta,H. and Yamagata,K.
  TITLE     SIRT7 has a critical role in bone formation by regulating lysine
            acylation of SP7/Osterix
  JOURNAL   Nat Commun 9 (1), 2833 (2018)
   PUBMED   30026585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Amorim,B.R., Okamura,H., Yoshida,K., Qiu,L., Morimoto,H. and
            Haneji,T.
  TITLE     The transcriptional factor Osterix directly interacts with RNA
            helicase A
  JOURNAL   Biochem Biophys Res Commun 355 (2), 347-351 (2007)
   PUBMED   17303075
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Wang,B.L., Dai,C.L., Quan,J.X., Zhu,Z.F., Zheng,F., Zhang,H.X.,
            Guo,S.Y., Guo,G., Zhang,J.Y. and Qiu,M.C.
  TITLE     Parathyroid hormone regulates osterix and Runx2 mRNA expression
            predominantly through protein kinase A signaling in osteoblast-like
            cells
  JOURNAL   J Endocrinol Invest 29 (2), 101-108 (2006)
   PUBMED   16610234
  REMARK    GeneRIF: Parathyroid hormone (1-34) regulates osterix mRNA
            expression, in rat osteoblast-like cell line UMR 106, in a dose-
            and time-dependent manner.
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Koga,T., Matsui,Y., Asagiri,M., Kodama,T., de Crombrugghe,B.,
            Nakashima,K. and Takayanagi,H.
  TITLE     NFAT and Osterix cooperatively regulate bone formation
  JOURNAL   Nat Med 11 (8), 880-885 (2005)
   PUBMED   16041384
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Milona,M.A., Gough,J.E. and Edgar,A.J.
  TITLE     Expression of alternatively spliced isoforms of human Sp7 in
            osteoblast-like cells
  JOURNAL   BMC Genomics 4, 43 (2003)
   PUBMED   14604442
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Nakashima,K., Zhou,X., Kunkel,G., Zhang,Z., Deng,J.M.,
            Behringer,R.R. and de Crombrugghe,B.
  TITLE     The novel zinc finger-containing transcription factor osterix is
            required for osteoblast differentiation and bone formation
  JOURNAL   Cell 108 (1), 17-29 (2002)
   PUBMED   11792318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001412.1.
            
            On Dec 23, 2004 this sequence version replaced NM_181374.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Sp7 transcription factor"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
     exon            1..119
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="isoform 2 is encoded by transcript variant 2;
                     osterix; Transcription factor Sp7"
                     /codon_start=1
                     /product="transcription factor Sp7 isoform 2"
                     /protein_id="NP_852039.2"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
                     /translation="MASSLLEEEAHYGSSPLAMLTAACSKFGGSSPLRDSTALGKGGT
                     KKPYTDLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGA
                     QDPGLLVPKGHSSSDCLPSVYTSLDMSHPYGSWYKAGIHAGISPGPGNTPTPWWDMHP
                     GGNWLGGGQGQGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQ
                     HVLPQDVYKPKAVGNSGQLEGSGAGKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELE
                     RLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTR
                     SDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGR
                     SVGEEEANQPPRSSTSPAPPEKAPGGSPEQSNLLEI"
     misc_feature    102..974
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="N-terminal domains of transcription factor
                     Specificity Proteins (SP) 6-9, and similar proteins;
                     Region: SP6-9_N; cl41771"
                     /db_xref="CDD:425402"
     misc_feature    102..974
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="N-terminal domains of transcription factor
                     Specificity Proteins (SP) 6-9, and similar proteins;
                     Region: SP6-9_N; cl41771"
                     /db_xref="CDD:425402"
     misc_feature    984..1043
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    984..1043
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(996..998,1002..1004,1008..1010,1014..1019,
                     1026..1031,1038..1040,1086..1088,1092..1094,1104..1109,
                     1116..1121,1128..1130,1170..1172,1176..1178,1182..1184,
                     1188..1193,1200..1205,1212..1214)
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(996..998,1002..1004,1008..1010,1014..1019,
                     1026..1031,1038..1040,1086..1088,1092..1094,1104..1109,
                     1116..1121,1128..1130,1170..1172,1176..1178,1182..1184,
                     1188..1193,1200..1205,1212..1214)
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1017..1100
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1017..1100
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1065..1133
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1065..1133
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1107..1184
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1107..1184
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1155..1217
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1155..1217
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            120..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctcccat tctccctccc tctccctttc ccctctccca ctggctcctg gttctctcca
       61 tctgcctgac tccttgggac ccggtcccca gcctgaggat ggcgtcctct ctgcttgagg
      121 aagaagctca ctatggctcc agtcccctgg ccatgctgac agcagcctgc agcaagtttg
      181 gtggctccag ccctctgcga gactcaacag ccctgggaaa aggaggcaca aagaagccat
      241 acactgacct ttcagccccc aaaaccatgg gggacgccta cccagctccc ttctcaagca
      301 ccaatggact cctctcccct gcaggcagtc ccccggcccc ggcctctggc tatgccaatg
      361 actacccacc ctttccccac tcatttcctg ggcccactgg tgcccaagac ccggggctgc
      421 tggtgccgaa ggggcacagc tcttctgact gcctgcctag tgtctacacg tccttggata
      481 tgtcccatcc ctacggctcc tggtacaagg cgggcatcca tgcaggcatc tcaccaggtc
      541 ctggcaacac tcctacccct tggtgggaca tgcaccctgg gggcaattgg ttaggtggtg
      601 ggcagggcca gggtgatggg ctgcaaggga cactgtccac aggccctgcc cagcctccac
      661 tgaaccccca gctgcctact tacccgtctg actttgcccc ccttaaccca gctccctatc
      721 cagcacccca cctcttgcaa ccaggtcccc agcatgtcct accccaagat gtctataagc
      781 ccaaggcagt tggcaatagt gggcaactgg aggggagtgg tgcaggcaaa cctccccggg
      841 gtgcaggcac agggggcagt ggtggatatg caggcagtgg ggcagggcgt tctacctgcg
      901 actgccccaa ctgtcaggag ctagagcggc tgggggcagc agcggctggg ctgaggaaga
      961 agcccattca cagctgccac atccccggct gcggcaaggt gtacggcaag gcttcgcatc
     1021 tgaaagccca cttgcgctgg cacactggcg agaggccttt cgtctgcaac tggcttttct
     1081 gtggcaagag gttcacccgc tctgacgagc tggagcgcca cgtgcgcact cacacccggg
     1141 agaagaagtt cacctgtctg ctctgctcca agcgctttac ccgaagcgac cacttgagca
     1201 aacatcagcg cacccacggg gagccaggtc ccgggccgcc cccaagtggc cctaaggagc
     1261 tgggggaggg tcgcagcgtc ggggaagaag aagccaatca gccgccccga tcttccacct
     1321 cgcctgcacc cccagaaaaa gcccctggag gcagcccaga gcagagcaac ctgctagaga
     1381 tctga
//
LOCUS       NM_001161691            1203 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus retinoic acid early transcript 1L like 1
            (Raet1ll1), mRNA.
ACCESSION   NM_001161691 XM_001054610
VERSION     NM_001161691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1203)
  AUTHORS   Zhuo,M., Fujiki,M., Wang,M., Piard-Ruster,K., Wai,L.E., Wei,L.,
            Martinez,O.M. and Krams,S.M.
  TITLE     Identification of the rat NKG2D ligands, RAE1L and RRLT, and their
            role in allograft rejection
  JOURNAL   Eur J Immunol 40 (6), 1748-1757 (2010)
   PUBMED   20306467
  REMARK    GeneRIF: We cloned and expressed two rat NKG2D ligands RAE1L and
            RRLT, and demonstrate that these ligands can induce IFN-gamma
            secretion and cytotoxicity by rat NK cells
REFERENCE   2  (bases 1 to 1203)
  AUTHORS   Savithri,B. and Khar,A.
  TITLE     A transmembrane-anchored rat RAE-1-like transcript as a ligand for
            NKR-P2, the rat ortholog of human and mouse NKG2D
  JOURNAL   Eur J Immunol 36 (1), 107-117 (2006)
   PUBMED   16323246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FJ971664.1.
            
            On Jun 12, 2009 this sequence version replaced XM_001054610.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ971664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..1203
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /note="retinoic acid early transcript 1L like 1"
                     /db_xref="GeneID:679825"
                     /db_xref="RGD:1583663"
     CDS             1..1203
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /note="Rae-1-like protein"
                     /codon_start=1
                     /product="retinoic acid early transcript 1L like 1"
                     /protein_id="NP_001155163.1"
                     /db_xref="GeneID:679825"
                     /db_xref="RGD:1583663"
                     /translation="MEGGVQAPSLTGRPSRVAVILTEGQASYKVPDNCWSYSVGDRHF
                     RESLSGILCGAAQNPHGFSQLRSHLLLRAGMAENTAAEHPLFTGASCVLVFLSCLGST
                     LCADVHSLSCNLIIRSPTKAEPLWYEGQCSMDGNVFLSSNNVNKTMPLGNQEKMANAT
                     EVWTCLTQWIDRCKQDLRDKVSEIKGDTTKTSGHPTLRVTMLSNHSHEQIIGASCVFN
                     ISENYSFILDLKTMKWKLINPVPEDIMKEWKDDKTLMKHLNLFIVECSPKFNEFLNQH
                     EERTRSTTRAPDITQPPPTSQVPYKEVLIPVGLIISIIFIIFLCICVKRMCCPHGGRE
                     LQLLKDYCINWHKPQRNEGLEETKGEVPNQRTKMLSQEEDPKTLGGPRRASESVELEL
                     QMFSSTGS"
     misc_feature    316..837
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    316..837
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     exon            1..316
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
     exon            317..577
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
     exon            578..841
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
     exon            842..994
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1136
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1203
                     /gene="Raet1ll1"
                     /gene_synonym="Rrlt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggtg gagttcaggc tcccagtttg accggacggc cttcccgcgt ggctgtgatc
       61 ctcacggagg gacaagcaag ctacaaagtt cctgacaatt gctggagtta cagcgttggt
      121 gaccggcatt ttcgtgaatc tctgagcggg atcctctgcg gggcggcaca gaatcctcac
      181 ggcttctcac agctcaggtc acacctgttg ctcagggcgg gtatggcaga gaatacagcc
      241 gctgagcatc ctctattcac aggagcttca tgcgttttgg tttttctgag ctgtctgggg
      301 tctacgctgt gcgctgatgt acactctctt agttgcaact tgatcatcag gtctcctacc
      361 aaagcagaac ctctctggta tgaaggacag tgttcaatgg atggaaatgt tttcctttct
      421 tctaataacg tgaacaagac catgcctttg ggtaaccagg agaagatggc aaatgccacc
      481 gaagtgtgga catgtttgac ccagtggata gaccgatgta aacaggactt aagggacaag
      541 gtgtctgaaa tcaaagggga cactaccaag accagtggtc accccacttt acgggtcacc
      601 atgctttcta accacagcca tgaacaaatc attggtgctt cctgtgtatt caacatcagt
      661 gagaattatt ccttcatctt ggacctaaag actatgaagt ggaaactgat taatcctgta
      721 ccagaggaca tcatgaaaga atggaaagat gataagacat taatgaaaca tctgaatttg
      781 ttcatagtag aatgcagtcc gaaattcaat gaattcttaa atcagcacga ggaaagaaca
      841 agatcaacaa caagggcccc agatatcacc cagcctccac ctaccagcca ggttccttat
      901 aaggaagtat tgatccctgt aggactcatc atttccatca tctttattat tttcctttgc
      961 atatgtgtga agaggatgtg ttgtccccac ggaggtagag aacttcagct gctcaaggac
     1021 tactgcatca actggcacaa gccacagagg aatgaggggc tagaggagac aaaaggagag
     1081 gttcccaacc agagaaccaa aatgttgtcc caggaggaag atcccaagac attgggaggc
     1141 ccaaggaggg catcagaatc tgtggaactg gagttacaga tgttttcaag tactgggagc
     1201 tga
//
LOCUS       NM_001009975            1077 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 7C (Taar7c),
            mRNA.
ACCESSION   NM_001009975 XM_579328
VERSION     NM_001009975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Fleischer,J., Schwarzenbacher,K. and Breer,H.
  TITLE     Expression of trace amine-associated receptors in the Grueneberg
            ganglion
  JOURNAL   Chem Senses 32 (6), 623-631 (2007)
   PUBMED   17556730
  REMARK    GeneRIF: Expression of Taar family members is limited to specific
            tissue subpopulations and developmental stages in mouse.
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702320.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579328.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1077
                     /gene="Taar7c"
                     /note="trace amine-associated receptor 7C"
                     /db_xref="GeneID:494535"
                     /db_xref="RGD:1359258"
     CDS             1..1077
                     /gene="Taar7c"
                     /note="taR-7c; trace amine receptor 7c; trace amine
                     associated receptor 7c"
                     /codon_start=1
                     /product="trace amine-associated receptor 7c"
                     /protein_id="NP_001009975.1"
                     /db_xref="GeneID:494535"
                     /db_xref="RGD:1359258"
                     /translation="MATDDDSFPWDQDSILSRDLLSASSLQLCYENLNRSCVRSPYSP
                     GSRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADLLVGLTVMP
                     FSMVRSVEGCWYFGNTYCKFHSCFEGSFCYSSLFHLCFISLDRYIAVSDPLIYPTRFT
                     ASISGKCITFSWLLSIIYSFSLLYTGANEAGLEDLVSALTCVGGCQVAVNQSWVFINF
                     LLFLVPALVMMTVYSKIFLIAKQQAQNIEKMSKQTARASESYKDRVAKRERKAAKTLG
                     IAVAAFLLSWLPYFIDSIIDAFLGFITPTYMYEILVWIVYYNSAMNPLIYAFFYPWFR
                     KAIKLIVTGKILRENSSTINLFPE"
     misc_feature    100..102
                     /gene="Taar7c"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD21.1); glycosylation site"
     misc_feature    142..204
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    145..1011
                     /gene="Taar7c"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    145..1011
                     /gene="Taar7c"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    148..222
                     /gene="Taar7c"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    148..222
                     /gene="Taar7c"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7c"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    247..315
                     /gene="Taar7c"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    250..312
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    361..429
                     /gene="Taar7c"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    361..429
                     /gene="Taar7c"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    376..444
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    496..546
                     /gene="Taar7c"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    496..546
                     /gene="Taar7c"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    499..561
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    628..699
                     /gene="Taar7c"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    628..699
                     /gene="Taar7c"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    634..696
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    814..882
                     /gene="Taar7c"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    814..882
                     /gene="Taar7c"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    823..885
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     misc_feature    913..990
                     /gene="Taar7c"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    913..990
                     /gene="Taar7c"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    928..996
                     /gene="Taar7c"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD21.1);
                     transmembrane region"
     exon            1..1077
                     /gene="Taar7c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctacag acgatgacag ttttccctgg gatcaggaca gcatcctgag cagagatctg
       61 ctctcagcct cgtctctcca gctgtgctat gagaacctga acagatcctg tgtcaggagc
      121 ccatactccc caggctctcg cctcatcctc tatgcagtct ttggctttgg ggctgtgctg
      181 gctgtgtgtg gaaacctcct ggtgatgaca tcaattcttc atttcaggca gctgcactct
      241 cctgccaact ttctggtggc ctccctggcc tgtgctgact tgttggtggg tctgactgtg
      301 atgcctttca gcatggtgag gtctgtggag ggctgctggt actttgggaa cacttactgt
      361 aaattccatt cttgtttcga agggtcattc tgctattcgt ctctcttcca cttgtgtttc
      421 atctctcttg atagatacat tgcagtcagt gaccccctga tttaccccac caggttcaca
      481 gcatctattt ctggtaagtg tatcaccttt tcctggctcc tgtccatcat ctacagcttt
      541 tccctccttt acacaggggc caatgaagct gggcttgagg atctagtgag tgccctcacc
      601 tgtgtgggtg gctgccaagt tgcagtgaat caaagctggg tcttcatcaa tttcctatta
      661 tttcttgtcc ctgcccttgt gatgatgact gtctactcta agattttcct cattgcaaag
      721 cagcaggctc agaacatcga gaagatgagc aagcagactg ccagggcatc tgaaagctac
      781 aaggacaggg tggccaagag ggagaggaaa gcagccaaaa ccctgggcat cgcagtggct
      841 gccttcctcc tttcatggct gccatatttc attgactcca tcattgacgc cttcctgggg
      901 ttcatcacgc ccacgtatat gtatgaaatc ctagtttgga tagtttacta taactcagcc
      961 atgaaccctt taatttatgc tttcttctat ccttggtttc gaaaagccat caaactcatt
     1021 gtaactggca aaatcttgag agaaaattcc tcaaccatca atttgttccc tgagtag
//
LOCUS       NM_022189               1346 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 3B (Htr3b), mRNA.
ACCESSION   NM_022189
VERSION     NM_022189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Enoch,M.A., Gorodetsky,E., Hodgkinson,C., Roy,A. and Goldman,D.
  TITLE     Functional genetic variants that increase synaptic serotonin and
            5-HT3 receptor sensitivity predict alcohol and drug dependence
  JOURNAL   Mol Psychiatry 16 (11), 1139-1146 (2011)
   PUBMED   20838391
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Ge,Q.F. and Zhang,H.Y.
  TITLE     [Effects of Chinese herbal medicines for regulating liver qi on
            expression of 5-hydroxytryptamine 3B receptor in hypothalamic
            tissues of rats with anger emotion]
  JOURNAL   Zhong Xi Yi Jie He Xue Bao 9 (8), 871-877 (2011)
   PUBMED   21849148
  REMARK    GeneRIF: Chinese herbal medicines for regulating liver qi may treat
            anger emotion in rats by improving the hypothalamic 5-HT3BR protein
            and gene expression levels.
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Doucet,E., Latremoliere,A., Darmon,M., Hamon,M. and Emerit,M.B.
  TITLE     Immunolabelling of the 5-HT 3B receptor subunit in the central and
            peripheral nervous systems in rodents
  JOURNAL   Eur J Neurosci 26 (2), 355-366 (2007)
   PUBMED   17650111
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Yamada,K., Hattori,E., Iwayama,Y., Ohnishi,T., Ohba,H., Toyota,T.,
            Takao,H., Minabe,Y., Nakatani,N., Higuchi,T., Detera-Wadleigh,S.D.
            and Yoshikawa,T.
  TITLE     Distinguishable haplotype blocks in the HTR3A and HTR3B region in
            the Japanese reveal evidence of association of HTR3B with female
            major depression
  JOURNAL   Biol Psychiatry 60 (2), 192-201 (2006)
   PUBMED   16487942
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Reeves,D.C. and Lummis,S.C.
  TITLE     Detection of human and rodent 5-HT3B receptor subunits by
            anti-peptide polyclonal antibodies
  JOURNAL   BMC Neurosci 7, 27 (2006)
   PUBMED   16571125
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1346)
  AUTHORS   Morales,M. and Wang,S.D.
  TITLE     Differential composition of 5-hydroxytryptamine3 receptors
            synthesized in the rat CNS and peripheral nervous system
  JOURNAL   J Neurosci 22 (15), 6732-6741 (2002)
   PUBMED   12151552
REFERENCE   7  (bases 1 to 1346)
  AUTHORS   Hanna,M.C., Davies,P.A., Hales,T.G. and Kirkness,E.F.
  TITLE     Evidence for expression of heteromeric serotonin 5-HT(3) receptors
            in rodents
  JOURNAL   J Neurochem 75 (1), 240-247 (2000)
   PUBMED   10854267
REFERENCE   8  (bases 1 to 1346)
  AUTHORS   Davies,P.A., Pistis,M., Hanna,M.C., Peters,J.A., Lambert,J.J.,
            Hales,T.G. and Kirkness,E.F.
  TITLE     The 5-HT3B subunit is a major determinant of serotonin-receptor
            function
  JOURNAL   Nature 397 (6717), 359-363 (1999)
   PUBMED   9950429
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF155044.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132271 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1346
                     /gene="Htr3b"
                     /note="5-hydroxytryptamine receptor 3B"
                     /db_xref="GeneID:58963"
                     /db_xref="RGD:61820"
     exon            1..72
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    21..23
                     /gene="Htr3b"
                     /note="upstream in-frame stop codon"
     CDS             33..1346
                     /gene="Htr3b"
                     /note="serotonin-gated ion channel subunit; 5-HT3B;
                     5-HT-3B; serotonin receptor 3B; 5-HT3-B;
                     5-hydroxytryptamine (serotonin) receptor 3B, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3B precursor"
                     /protein_id="NP_071525.1"
                     /db_xref="GeneID:58963"
                     /db_xref="RGD:61820"
                     /translation="MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVR
                     PVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEI
                     SLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPF
                     DIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSS
                     AGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVG
                     YTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERP
                     LMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRD
                     QVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM"
     sig_peptide     33..95
                     /gene="Htr3b"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ16.1)"
     mat_peptide     96..1343
                     /gene="Htr3b"
                     /product="5-hydroxytryptamine receptor 3B.
                     /id=PRO_0000312291"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1)"
     misc_feature    105..731
                     /gene="Htr3b"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); Region: LGIC_ECD;
                     cl28912"
                     /db_xref="CDD:475126"
     misc_feature    105..731
                     /gene="Htr3b"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); Region: LGIC_ECD;
                     cl28912"
                     /db_xref="CDD:475126"
     misc_feature    105..107
                     /gene="Htr3b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ16.1); glycosylation site"
     misc_feature    order(219..221,225..227,243..248,267..269,333..335,
                     339..341,366..371,375..377,381..386,414..422,426..428,
                     456..458,462..464,468..470,480..482,546..548)
                     /gene="Htr3b"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349787"
     misc_feature    order(219..221,225..227,243..248,267..269,333..335,
                     339..341,366..371,375..377,381..386,414..422,426..428,
                     456..458,462..464,468..470,480..482,546..548)
                     /gene="Htr3b"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349787"
     misc_feature    306..308
                     /gene="Htr3b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ16.1); glycosylation site"
     misc_feature    432..434
                     /gene="Htr3b"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ16.1); glycosylation site"
     misc_feature    738..1328
                     /gene="Htr3b"
                     /note="transmembrane domain of 5-hydroxytryptamine 3
                     (5-HT3) receptor; Region: LGIC_TM_5-HT3; cd19063"
                     /db_xref="CDD:349865"
     misc_feature    738..1328
                     /gene="Htr3b"
                     /note="transmembrane domain of 5-hydroxytryptamine 3
                     (5-HT3) receptor; Region: LGIC_TM_5-HT3; cd19063"
                     /db_xref="CDD:349865"
     misc_feature    738..812
                     /gene="Htr3b"
                     /note="TM1 helix [structural motif]; Region: TM1 helix"
                     /db_xref="CDD:349865"
     misc_feature    738..812
                     /gene="Htr3b"
                     /note="TM1 helix [structural motif]; Region: TM1 helix"
                     /db_xref="CDD:349865"
     misc_feature    738..797
                     /gene="Htr3b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1);
                     transmembrane region"
     misc_feature    order(774..776,786..788,795..797,804..812,822..827,
                     831..839,843..848,852..860,864..866,876..881,897..902,
                     948..950,960..962,969..974,981..983,990..995,1002..1004,
                     1236..1238,1248..1250)
                     /gene="Htr3b"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349865"
     misc_feature    order(774..776,786..788,795..797,804..812,822..827,
                     831..839,843..848,852..860,864..866,876..881,897..902,
                     948..950,960..962,969..974,981..983,990..995,1002..1004,
                     1236..1238,1248..1250)
                     /gene="Htr3b"
                     /note="pentamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349865"
     misc_feature    831..884
                     /gene="Htr3b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1);
                     transmembrane region"
     misc_feature    834..899
                     /gene="Htr3b"
                     /note="TM2 helix [structural motif]; Region: TM2 helix"
                     /db_xref="CDD:349865"
     misc_feature    834..899
                     /gene="Htr3b"
                     /note="TM2 helix [structural motif]; Region: TM2 helix"
                     /db_xref="CDD:349865"
     misc_feature    918..1004
                     /gene="Htr3b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1);
                     transmembrane region"
     misc_feature    930..998
                     /gene="Htr3b"
                     /note="TM3 helix [structural motif]; Region: TM3 helix"
                     /db_xref="CDD:349865"
     misc_feature    930..998
                     /gene="Htr3b"
                     /note="TM3 helix [structural motif]; Region: TM3 helix"
                     /db_xref="CDD:349865"
     misc_feature    1161..1259
                     /gene="Htr3b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1);
                     Region: HA-stretch, determines single-channel conductance
                     in 5-HT3 receptors.
                     /evidence=ECO:0000250|UniProtKB:O95264"
     misc_feature    1251..1319
                     /gene="Htr3b"
                     /note="TM4 helix [structural motif]; Region: TM4 helix"
                     /db_xref="CDD:349865"
     misc_feature    1251..1319
                     /gene="Htr3b"
                     /note="TM4 helix [structural motif]; Region: TM4 helix"
                     /db_xref="CDD:349865"
     misc_feature    1263..1334
                     /gene="Htr3b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ16.1);
                     transmembrane region"
     exon            73..233
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            234..278
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            279..388
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            389..558
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            559..716
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            717..927
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1110
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1346
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtacctgc cccagaacaa taggcaagtg cgatgattct tctgtggtcc tgcctcctgg
       61 tggctgtcgt aggtattcta ggcacagcga cacctcagcc tgggaattcc tctctgcatc
      121 gcctcaccag gcagctgcta cagcagtacc acaaggaggt cagaccagtt tacaactggg
      181 ctgaggccac cactgtctac ctggaccttt gcgtccatgc tgtattggat gtggatgtac
      241 agaatcaaaa attaaagaca agcatgtggt accgagaggt ttggaatgat gagtttctgt
      301 cctggaactc tagtctgttc gatgatattc aagagatctc tctccctctc agtgccatct
      361 gggcccctga tatcatcatt aatgagtttg tggatgtcga aaggtctcct gacctgccct
      421 atgtatacgt gaactcttcc ggaacgatta gaaaccacaa gcccatccag gtggtctccg
      481 catgcagttt gcagacatac gctttcccct ttgatatcca gaactgcagt ctcaccttca
      541 atagcatcct gcatacagtg gaagacatag acctgggctt cctgaggaac caagaagaca
      601 ttgagaacga caaaaggtct tttctgaatg acagcgagtg gcagcttctt tctgtgacct
      661 ccacttacca catccggcag agcagcgctg gtgacttcgc acagattcgg tttaatgtag
      721 tgattcgcag atgtccattg gcctatgttg tgagcctctt gattcctagc atcttcctga
      781 tgctcgtgga cctgggaagc ttctacttgc cccccaactg tcgtgccaga attgtgttca
      841 agaccaatgt gctggtgggc tatacagtct tcagggtcaa catgtctgat gaggtgccaa
      901 gaagcgcagg gtgcacatct ctgattgggg tcttctttac cgtctgcatg gccctcttgg
      961 ttctcagttt atccaaatcc atcttgttga tcaaattcct ctatgaggag cggcacagtg
     1021 agcaagaacg gcctcttatg tgccttcgag gggactctga tgccaatgag tctagattgt
     1081 acctcagagc tccatgtgct gaggacacag agtccccggt tcgtcaggag caccaggtcc
     1141 catcagatac tctgaaggat ttctggttcc agctccaatc catcaacaac tctctccgaa
     1201 ctcgggatca ggtttaccag aaggaggtgg agtggctcgc catcctgtgc cactttgatc
     1261 agctgctctt ccgaatctac cttgccgtgc tggggctcta tactgtcacc ttatgctctc
     1321 tctgggcact gtggagcagg atgtga
//
LOCUS       NM_001101017             792 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus similar to RT1 class II histocompatibility
            antigen, B-1 beta chain precursor (RT1.B-beta(1)) (LOC688090),
            mRNA.
ACCESSION   NM_001101017 XM_001081089
VERSION     NM_001101017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 792)
  AUTHORS   Tuncel,J., Haag,S., Yau,A.C., Norin,U., Baud,A., Lonnblom,E.,
            Maratou,K., Ytterberg,A.J., Ekman,D., Thordardottir,S.,
            Johannesson,M., Gillett,A., Stridh,P., Jagodic,M., Olsson,T.,
            Fernandez-Teruel,A., Zubarev,R.A., Mott,R., Aitman,T.J., Flint,J.
            and Holmdahl,R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 792)
  AUTHORS   Ettinger,R.A., Moustakas,A.K. and Lobaton,S.D.
  TITLE     Open reading frame sequencing and structure-based alignment of
            polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles
  JOURNAL   Immunogenetics 56 (8), 585-596 (2004)
   PUBMED   15517241
REFERENCE   3  (bases 1 to 792)
  AUTHORS   Fujii,H., Kakinuma,M., Yoshiki,T. and Natori,T.
  TITLE     Polymorphism of the class II gene of rat major histocompatibility
            complex, RT1: partial sequence comparison of the first domain of
            the RT1.B beta 1 alleles
  JOURNAL   Immunogenetics 33 (5-6), 399-403 (1991)
   PUBMED   1904838
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            AY626184.1.
            
            On Aug 13, 2007 this sequence version replaced XM_001081089.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY626181.1, AY626184.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR/NCrlBR"
                     /db_xref="taxon:10116"
                     /chromosome="20"
     gene            1..792
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="similar to RT1 class II histocompatibility antigen,
                     B-1 beta chain precursor (RT1.B-beta(1))"
                     /db_xref="GeneID:688090"
                     /db_xref="RGD:1593573"
     CDS             1..792
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="MHC class II antigen RT1.B beta chain"
                     /codon_start=1
                     /product="uncharacterized protein LOC688090 precursor"
                     /protein_id="NP_001094487.1"
                     /db_xref="GeneID:688090"
                     /db_xref="RGD:1593573"
                     /translation="MALQTPSFLLPAAVVVLMVLSSPGTEGRDSPRDFVYQFEGQCYY
                     TNGTQRMRLVTRHIYNREEYVRFDSDLGEYRALTELGRPSAEYWNKQYLEQTRAELDR
                     VCRYNYEGPAALTSLRRLEQPNVAISLSRTEALNHHNLLVCSVTDFYPAQIKVRWFRN
                     GQEETTGVVSTQLIRNGDWTFQILVMLEMTPQRGDVYTCHVDHPSLESPVTVEWRAQS
                     ESAQSKMLSGIGGFVLGVIFLGLGLFIHHKSQKGPRGPPPAGLLQ"
     sig_peptide     1..81
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    118..327
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Class II histocompatibility antigen, beta domain;
                     Region: MHC_II_beta; smart00921"
                     /db_xref="CDD:197989"
     misc_feature    118..327
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Class II histocompatibility antigen, beta domain;
                     Region: MHC_II_beta; smart00921"
                     /db_xref="CDD:197989"
     misc_feature    361..648
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Class II major histocompatibility complex (MHC)
                     beta chain immunoglobulin domain of histocompatibility
                     antigen (HLA) DQ and I-A; member of the C1-set of Ig
                     superfamily (IgSF) domains; Region:
                     IgC1_MHC_II_beta_HLA-DQ_I-A; cd21001"
                     /db_xref="CDD:409592"
     misc_feature    361..648
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Class II major histocompatibility complex (MHC)
                     beta chain immunoglobulin domain of histocompatibility
                     antigen (HLA) DQ and I-A; member of the C1-set of Ig
                     superfamily (IgSF) domains; Region:
                     IgC1_MHC_II_beta_HLA-DQ_I-A; cd21001"
                     /db_xref="CDD:409592"
     misc_feature    364..390
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409592"
     misc_feature    364..390
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409592"
     misc_feature    order(382..384,436..441,445..447,523..546)
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409592"
     misc_feature    order(382..384,436..441,445..447,523..546)
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409592"
     misc_feature    418..447
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409592"
     misc_feature    418..447
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409592"
     misc_feature    order(445..447,529..537,541..543)
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409592"
     misc_feature    order(445..447,529..537,541..543)
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409592"
     misc_feature    457..477
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409592"
     misc_feature    457..477
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409592"
     misc_feature    481..492
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409592"
     misc_feature    481..492
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409592"
     misc_feature    502..528
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409592"
     misc_feature    502..528
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409592"
     misc_feature    535..567
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409592"
     misc_feature    535..567
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409592"
     misc_feature    586..609
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409592"
     misc_feature    586..609
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409592"
     misc_feature    628..642
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409592"
     misc_feature    628..642
                     /gene="LOC688090"
                     /gene_synonym="Bb; RT1-Bb"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409592"
ORIGIN      
        1 atggctctgc agacccccag cttcctcctc ccagcagctg tggttgtgct gatggtgctg
       61 agtagcccag ggactgaggg cagagactcc ccaagggatt tcgtgtacca gttcgagggc
      121 cagtgctact acaccaacgg gacgcagcgc atgcggctcg tgaccagaca catctacaac
      181 cgggaggagt acgtgcgctt cgacagcgac ctgggcgagt accgcgcgct gaccgagctg
      241 gggcggccct cagccgagta ctggaataag cagtacctgg agcagacgcg ggccgagctg
      301 gacagggtct gcagatacaa ctacgagggg ccggcggctc tcacctccct gagacggctt
      361 gagcagccca atgtggccat ctccctgtcc aggacagagg cccttaacca ccacaacctg
      421 ctggtctgct cagtgacaga tttctaccca gcccagatca aagtgcgctg gttccggaat
      481 ggccaggagg agacgacggg ggtcgtgtcc acacagctta ttaggaacgg ggactggacc
      541 ttccagatcc tggtcatgct ggagatgacg cctcagcggg gagatgtgta cacctgccat
      601 gttgaccacc ccagccttga gagccctgtc acagtggagt ggcgggcaca gtccgagtct
      661 gcccagagca agatgctgag cggcatcggg ggctttgtgc tgggggtgat attcctcggg
      721 cttggccttt tcatccatca caagagtcag aaagggcctc gggggcctcc tccagcaggg
      781 ctcctacagt ga
//
LOCUS       NM_134328                999 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus trace-amine-associated receptor 1 (Taar1), mRNA.
ACCESSION   NM_134328
VERSION     NM_134328.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Raony,I., Domith,I., Lourenco,M.V., Paes-de-Carvalho,R. and
            Pandolfo,P.
  TITLE     Trace amine-associated receptor 1 modulates motor hyperactivity,
            cognition, and anxiety-like behavior in an animal model of ADHD
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 117, 110555 (2022)
   PUBMED   35346791
  REMARK    GeneRIF: Trace amine-associated receptor 1 modulates motor
            hyperactivity, cognition, and anxiety-like behavior in an animal
            model of ADHD.
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Liu,J.F., Siemian,J.N., Seaman,R. Jr., Zhang,Y. and Li,J.X.
  TITLE     Role of TAAR1 within the Subregions of the Mesocorticolimbic
            Dopaminergic System in Cocaine-Seeking Behavior
  JOURNAL   J Neurosci 37 (4), 882-892 (2017)
   PUBMED   28123023
  REMARK    GeneRIF: TAAR1 in different subregions of the mesocorticolimbic
            system contributes to reinstatement of cocaine-seeking behavior.
REFERENCE   3  (bases 1 to 999)
  AUTHORS   De Gregorio,D., Posa,L., Ochoa-Sanchez,R., McLaughlin,R.,
            Maione,S., Comai,S. and Gobbi,G.
  TITLE     The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine
            firing activity through 5-HT1A, D2 and TAAR1 receptors
  JOURNAL   Pharmacol Res 113 (Pt A), 81-91 (2016)
   PUBMED   27544651
  REMARK    GeneRIF: Pretreatment with the trace amine-associate receptor 1
            (TAAR1) antagonist EPPTB (5mg/kg, i.v.) blocked the inhibitory
            effect of LSD on VTA DA neurons.
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Harmeier,A., Obermueller,S., Meyer,C.A., Revel,F.G., Buchy,D.,
            Chaboz,S., Dernick,G., Wettstein,J.G., Iglesias,A., Rolink,A.,
            Bettler,B. and Hoener,M.C.
  TITLE     Trace amine-associated receptor 1 activation silences GSK3beta
            signaling of TAAR1 and D2R heteromers
  JOURNAL   Eur Neuropsychopharmacol 25 (11), 2049-2061 (2015)
   PUBMED   26372541
  REMARK    GeneRIF: Results demonstrate that betaArr2 signaling may be an
            important pathway for TAAR1 function and that the activation of the
            TAAR1-D2R complex negatively modulates GSK3b signaling
REFERENCE   5  (bases 1 to 999)
  AUTHORS   Staubert,C., Bohnekamp,J. and Schoneberg,T.
  TITLE     Determinants involved in subtype-specific functions of rat trace
            amine-associated receptors 1 and 4
  JOURNAL   Br J Pharmacol 168 (5), 1266-1278 (2013)
   PUBMED   23072560
  REMARK    GeneRIF: The different functionality of rat Taar subtypes 1 and 4
            mainly correlates with receptor's cell surface expression rather
            than with specific amino acid residues involved in ligand binding
            specificity.
REFERENCE   6  (bases 1 to 999)
  AUTHORS   Miller,G.M.
  TITLE     The emerging role of trace amine-associated receptor 1 in the
            functional regulation of monoamine transporters and dopaminergic
            activity
  JOURNAL   J Neurochem 116 (2), 164-176 (2011)
   PUBMED   21073468
  REMARK    GeneRIF: Overview focuses on recent studies which reveal a role for
            TAAR1 in the functional regulation of monoamine transporters and
            the neuronal regulatory mechanisms that modulate dopaminergic
            activity. [review]
            Review article
REFERENCE   7  (bases 1 to 999)
  AUTHORS   Kitahama,K., Araneda,S., Geffard,M., Sei,H. and Okamura,H.
  TITLE     Tyramine-immunoreactive neuronal structures in the rat brain:
            abundance in the median eminence of the mediobasal hypothalamus
  JOURNAL   Neurosci Lett 383 (3), 215-219 (2005)
   PUBMED   15955414
  REMARK    GeneRIF: The Tyramine highly concentrated in the median eminence of
            the mediobasal hypothalamus, in which its physiological function on
            prolactin release has been demonstrated.
REFERENCE   8  (bases 1 to 999)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   9  (bases 1 to 999)
  AUTHORS   Bunzow,J.R., Sonders,M.S., Arttamangkul,S., Harrison,L.M.,
            Zhang,G., Quigley,D.I., Darland,T., Suchland,K.L., Pasumamula,S.,
            Kennedy,J.L., Olson,S.B., Magenis,R.E., Amara,S.G. and Grandy,D.K.
  TITLE     Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid
            diethylamide, and metabolites of the catecholamine
            neurotransmitters are agonists of a rat trace amine receptor
  JOURNAL   Mol Pharmacol 60 (6), 1181-1188 (2001)
   PUBMED   11723224
REFERENCE   10 (bases 1 to 999)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF421352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF421352.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="trace-amine-associated receptor 1"
                     /db_xref="GeneID:113914"
                     /db_xref="RGD:621621"
     CDS             1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /codon_start=1
                     /product="trace amine-associated receptor 1"
                     /protein_id="NP_599155.1"
                     /db_xref="GeneID:113914"
                     /db_xref="RGD:621621"
                     /translation="MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVI
                     ISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTD
                     IMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFL
                     ELNLEGVEEQYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKG
                     QARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGY
                     VIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL"
     misc_feature    25..27
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y9.1); glycosylation site"
     misc_feature    46..48
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y9.1); glycosylation site"
     misc_feature    73..936
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="trace amine-associated receptor 1 and similar
                     receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR1; cd15314"
                     /db_xref="CDD:320438"
     misc_feature    73..936
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="trace amine-associated receptor 1 and similar
                     receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR1; cd15314"
                     /db_xref="CDD:320438"
     misc_feature    73..150
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320438"
     misc_feature    73..150
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320438"
     misc_feature    73..135
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    169..249
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320438"
     misc_feature    169..249
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320438"
     misc_feature    175..237
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    283..375
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320438"
     misc_feature    283..375
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320438"
     misc_feature    order(292..294,304..309,316..321,547..549,568..570,
                     577..582,589..591,781..783,790..795,802..804,847..849,
                     859..861,871..873)
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320438"
     misc_feature    order(292..294,304..309,316..321,547..549,568..570,
                     577..582,589..591,781..783,790..795,802..804,847..849,
                     859..861,871..873)
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320438"
     misc_feature    292..354
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    409..480
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320438"
     misc_feature    409..480
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320438"
     misc_feature    415..477
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    556..645
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320438"
     misc_feature    556..645
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320438"
     misc_feature    562..624
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    721..813
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320438"
     misc_feature    721..813
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320438"
     misc_feature    748..810
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     misc_feature    838..915
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320438"
     misc_feature    838..915
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320438"
     misc_feature    847..849
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y9.1); glycosylation site"
     misc_feature    862..924
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y9.1);
                     transmembrane region"
     exon            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcatcttt gccacaatag cgcgaatatt tcccacacga acagcaactg gtcaagggat
       61 gtccgtgctt cactgtacag cttaatatca ctcataattc taaccactct ggttggcaac
      121 ttaatagtaa tcatttcgat atcccacttc aagcaacttc acacgcccac aaattggctc
      181 cttcattcca tggccgttgt cgactttctg ctgggctgtc tggtcatgcc ctacagcatg
      241 gtgagaacag ttgagcactg ctggtacttt ggggaactct tctgcaaact tcacaccagc
      301 actgatatca tgctgagctc ggcatccatt ctccacctag ccttcatttc cattgaccgc
      361 tactatgctg tgtgcgaccc tttaagatac aaagccaaga tcaatctcgc cgccattttt
      421 gtgatgatcc tcattagctg gagccttcct gctgtttttg catttgggat gatcttcctg
      481 gagctgaact tagaaggagt tgaggagcag tatcacaatc aggtcttctg cctgcgcggc
      541 tgttttccct tcttcagtaa agtatctggg gtactggcat tcatgacgtc tttctatata
      601 cctggatctg ttatgttatt tgtttactat agaatatatt tcatagctaa aggacaagcg
      661 aggtcaatta atcgtgcaaa tcttcaagtt ggattggaag gggaaagcag agcgccacaa
      721 agcaaggaaa caaaagccgc aaaaacctta gggatcatgg tgggcgtttt cctcctgtgc
      781 tggtgcccgt tctttttctg catggtcctg gaccctttcc tgggctatgt tatcccaccc
      841 actctgaatg acacactgaa ttggttcggg tacctgaact ctgccttcaa cccgatggtt
      901 tatgcctttt tctatccctg gttcagaaga gcgttgaaga tggttctctt cggtaaaatt
      961 ttccaaaaag attcatctag gtctaagtta tttttgtaa
//
LOCUS       NM_001109261            1208 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus paired box 5 (Pax5), mRNA.
ACCESSION   NM_001109261 XM_001070941 XM_575815
VERSION     NM_001109261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Ohtsuka,N., Badurek,S., Busslinger,M., Benes,F.M., Minichiello,L.
            and Rudolph,U.
  TITLE     GABAergic neurons regulate lateral ventricular development via
            transcription factor Pax5
  JOURNAL   Genesis 51 (4), 234-245 (2013)
   PUBMED   23349049
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Holmes,M.L., Carotta,S., Corcoran,L.M. and Nutt,S.L.
  TITLE     Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
  JOURNAL   Genes Dev 20 (8), 933-938 (2006)
   PUBMED   16618805
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Johnson,K., Pflugh,D.L., Yu,D., Hesslein,D.G., Lin,K.I.,
            Bothwell,A.L., Thomas-Tikhonenko,A., Schatz,D.G. and Calame,K.
  TITLE     B cell-specific loss of histone 3 lysine 9 methylation in the V(H)
            locus depends on Pax5
  JOURNAL   Nat Immunol 5 (8), 853-861 (2004)
   PUBMED   15258579
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Wu,C.X., Zhao,W.P., Kishi,H., Dokan,J., Jin,Z.X., Wei,X.C.,
            Yokoyama,K.K. and Muraguchi,A.
  TITLE     Activation of mouse RAG-2 promoter by Myc-associated zinc finger
            protein
  JOURNAL   Biochem Biophys Res Commun 317 (4), 1096-1102 (2004)
   PUBMED   15094381
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Merluzzi,S., Moretti,M., Altamura,S., Zwollo,P., Sigvardsson,M.,
            Vitale,G. and Pucillo,C.
  TITLE     CD40 stimulation induces Pax5/BSAP and EBF activation through a
            APE/Ref-1-dependent redox mechanism
  JOURNAL   J Biol Chem 279 (3), 1777-1786 (2004)
   PUBMED   14594818
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Jin,Z.X., Kishi,H., Wei,X.C., Matsuda,T., Saito,S. and Muraguchi,A.
  TITLE     Lymphoid enhancer-binding factor-1 binds and activates the
            recombination-activating gene-2 promoter together with c-Myb and
            Pax-5 in immature B cells
  JOURNAL   J Immunol 169 (7), 3783-3792 (2002)
   PUBMED   12244173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575815.2, XM_001070941.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680425
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="paired box 5"
                     /db_xref="GeneID:500453"
                     /db_xref="RGD:1565236"
     exon            1..78
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /codon_start=1
                     /product="paired box protein Pax-5"
                     /protein_id="NP_001102731.1"
                     /db_xref="GeneID:500453"
                     /db_xref="RGD:1565236"
                     /translation="MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVEL
                     AHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEY
                     KRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVS
                     TGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRD
                     FLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGSLDD
                     MKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTG
                     MVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH"
     misc_feature    78..452
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    78..452
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    order(93..98,111..113,117..125,129..131,144..146,180..182,
                     186..188,213..215,222..224,228..233,243..245,270..290,
                     294..305,360..368,423..425,429..434,441..443,450..452)
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    order(93..98,111..113,117..125,129..131,144..146,180..182,
                     186..188,213..215,222..224,228..233,243..245,270..290,
                     294..305,360..368,423..425,429..434,441..443,450..452)
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    867..1202
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     misc_feature    867..1202
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     exon            79..244
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            245..442
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            443..507
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            508..636
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            637..812
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            813..942
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1044
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1131
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1208
                     /gene="Pax5"
                     /gene_synonym="RGD1565236"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatccatttc atcaaatcct gaaataatca aaatggattt agagaaaaat tacccaactc
       61 ctcggaccat caggacagga catggaggag tgaatcagct tgggggggtt tttgtgaatg
      121 gacggccact cccagatgta gtccgccaaa ggatagtgga acttgcccat caaggtgtca
      181 ggccctgcga catctccagg cagcttcggg tcagccatgg ttgtgtcagc aaaattcttg
      241 gcaggtatta tgagacagga agcatcaagc cgggggtgat cggaggatcc aaaccaaagg
      301 ttgccactcc caaagtggtg gaaaaaatcg ctgagtacaa acgccaaaat cctaccatgt
      361 ttgcctggga gatcagggac cggctgctgg cagagcgagt gtgtgacaat gacacagtgc
      421 ccagtgtcag ctccatcaac aggatcatcc ggacaaaagt acagcagccc cccaatcagc
      481 cggtcccagc ttccagtcac agcatagtgt ctacaggctc cgtgacgcag gtgtcgtcgg
      541 tgagcaccga ctctgcaggc tcctcgtact ccatcagcgg catcctgggc atcacgtccc
      601 ccagtgccga caccaacaag cgcaagaggg atgaaggtat tcaggagtct cccgtgccga
      661 atggccactc acttccaggc cgagacttcc tccgaaagca gatgcgggga gatctgttca
      721 cacagcagca gctggaggtg ctggaccgcg tgttcgagag acagcactac tcagacatct
      781 tcaccaccac ggagcccatc aagccagagc agaccacaga gtattcagcc atggcttcac
      841 tggctggaag cctggatgat atgaaagcca acttgacaag ccccaccccc gctgacatcg
      901 ggagcagcgt tccaggcccg cagtcctacc ccattgtcac aggccgagac ttggcaagca
      961 cgacccttcc ggggtaccct ccgcacgtgc cccccgctgg acagggcagc tactctgcac
     1021 cgacgctgac agggatggtg cctgggagcg aattttctgg gagtccctac agccaccctc
     1081 aatattcctc ctacaatgat tcatggaggt tccccaaccc agggctgctc ggctccccat
     1141 actattacag cgccgcagcc cgaggagccg ccccaccggc cgcagccacc gcctacgacc
     1201 gccactga
//
LOCUS       NM_020537               1161 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus urotensin 2 receptor (Uts2r), mRNA.
ACCESSION   NM_020537
VERSION     NM_020537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Ajiboye,B.O., Oyinloye,B.E., Onikanni,S.A., Osukoya,O.A.,
            Lawal,O.E. and Bamisaye,F.A.
  TITLE     Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate
            Cardiomyopathy in Streptozotocin-induced Diabetic Rats via
            Urotensin II and FABP3 Expressions
  JOURNAL   J Oleo Sci 70 (12), 1805-1814 (2021)
   PUBMED   34866110
  REMARK    GeneRIF: Sterculia tragacantha Lindl Aqueous Leaf Extract
            Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats
            via Urotensin II and FABP3 Expressions.
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Cadirci,E., Halici,Z., Yayla,M., Toktay,E., Bayir,Y., Karakus,E.,
            Topcu,A., Buyuk,B. and Albayrak,A.
  TITLE     Blocking of urotensin receptors as new target for treatment of
            carrageenan induced inflammation in rats
  JOURNAL   Peptides 82, 35-43 (2016)
   PUBMED   27208703
  REMARK    GeneRIF: This study investigated possible role of U-II and its
            receptor expression in inflammation by using UTR agonist and
            antagonist in carrageenan induced acute inflammation
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Liu,L.M., Liang,D.Y., Ye,C.G., Tu,W.J. and Zhu,T.
  TITLE     The UII/UT system mediates upregulation of proinflammatory
            cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated
            Kupffer cells
  JOURNAL   PLoS One 10 (3), e0121383 (2015)
   PUBMED   25803040
  REMARK    GeneRIF: The UII/UT system mediates upregulation of proinflammatory
            cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated
            Kupffer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1161)
  AUTHORS   Sainsily,X., Cabana,J., Holleran,B.J., Escher,E., Lavigne,P. and
            Leduc,R.
  TITLE     Identification of transmembrane domain 1 & 2 residues that
            contribute to the formation of the ligand-binding pocket of the
            urotensin-II receptor
  JOURNAL   Biochem Pharmacol 92 (2), 280-288 (2014)
   PUBMED   25175740
  REMARK    GeneRIF: Key transmembrane domain 1 and 2 residues were identified
            in urotensin-II receptor (UT) that participate in the formation of
            the UT receptor binding pocket.
REFERENCE   5  (bases 1 to 1161)
  AUTHORS   Tian,L., Li,Y., Hua,W., Jia,Y., Zhou,M., Gu,Y. and Qi,J.
  TITLE     Expression of Urotensin II During Focal Cerebral Ischemic in
            Diabetic Rats
  JOURNAL   Can J Neurol Sci 41 (4), 498-503 (2014)
   PUBMED   24878476
  REMARK    GeneRIF: Expression of GPR14 was increased at mRNA and protein
            levels in brain from cerebral ischemia rats.
REFERENCE   6  (bases 1 to 1161)
  AUTHORS   Sugo,T., Murakami,Y., Shimomura,Y., Harada,M., Abe,M.,
            Ishibashi,Y., Kitada,C., Miyajima,N., Suzuki,N., Mori,M. and
            Fujino,M.
  TITLE     Identification of urotensin II-related peptide as the urotensin
            II-immunoreactive molecule in the rat brain
  JOURNAL   Biochem Biophys Res Commun 310 (3), 860-868 (2003)
   PUBMED   14550283
REFERENCE   7  (bases 1 to 1161)
  AUTHORS   Boucard,A.A., Sauve,S.S., Guillemette,G., Escher,E. and Leduc,R.
  TITLE     Photolabelling the rat urotensin II/GPR14 receptor identifies a
            ligand-binding site in the fourth transmembrane domain
  JOURNAL   Biochem J 370 (Pt 3), 829-838 (2003)
   PUBMED   12495432
  REMARK    GeneRIF: Results indicate that position 6 of urotensin-II normally
            occupied by phenylalanine would interact with Met(184) and/or
            Met(185) of the fourth transmembrane domain of the urotensin-II
            receptor (GPR14).
REFERENCE   8  (bases 1 to 1161)
  AUTHORS   Liu,Q., Pong,S.S., Zeng,Z., Zhang,Q., Howard,A.D., Williams,D.L.
            Jr., Davidoff,M., Wang,R., Austin,C.P., McDonald,T.P., Bai,C.,
            George,S.R., Evans,J.F. and Caskey,C.T.
  TITLE     Identification of urotensin II as the endogenous ligand for the
            orphan G-protein-coupled receptor GPR14
  JOURNAL   Biochem Biophys Res Commun 266 (1), 174-178 (1999)
   PUBMED   10581185
REFERENCE   9  (bases 1 to 1161)
  AUTHORS   Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
            Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
  TITLE     Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
            and GPR14, encoding receptors related to interleukin 8,
            neuropeptide Y, and somatostatin receptors
  JOURNAL   Genomics 29 (2), 335-344 (1995)
   PUBMED   8666380
REFERENCE   10 (bases 1 to 1161)
  AUTHORS   Tal,M., Ammar,D.A., Karpuj,M., Krizhanovsky,V., Naim,M. and
            Thompson,D.A.
  TITLE     A novel putative neuropeptide receptor expressed in neural tissue,
            including sensory epithelia
  JOURNAL   Biochem Biophys Res Commun 209 (2), 752-759 (1995)
   PUBMED   7733947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB012210.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB029611.1, AB012210.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin 2 receptor"
                     /db_xref="GeneID:57305"
                     /db_xref="RGD:621884"
     CDS             1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin II receptor; UR-II-R; G-protein coupled
                     receptor 14; G-protein coupled sensory epithelial
                     neuropeptide-like receptor; putative G protein-coupled
                     receptor (SENR)"
                     /codon_start=1
                     /product="urotensin-2 receptor"
                     /protein_id="NP_065412.1"
                     /db_xref="GeneID:57305"
                     /db_xref="RGD:621884"
                     /translation="MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSS
                     LKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLL
                     SIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQ
                     RSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGT
                     SIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFW
                     LWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRS
                     LGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL"
     misc_feature    85..87
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49684.2); glycosylation site"
     misc_feature    97..99
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49684.2); glycosylation site"
     misc_feature    160..984
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin-II receptor, member of the class A family
                     of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_UII-R; cd14999"
                     /db_xref="CDD:320130"
     misc_feature    160..984
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="urotensin-II receptor, member of the class A family
                     of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_UII-R; cd14999"
                     /db_xref="CDD:320130"
     misc_feature    160..237
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320130"
     misc_feature    160..237
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320130"
     misc_feature    163..231
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    256..330
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320130"
     misc_feature    256..330
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320130"
     misc_feature    262..339
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    order(319..321,328..333,367..384,388..393,400..402,
                     532..534,538..552,622..624,631..639,643..651,655..660,
                     814..816,823..828,832..837,844..846,883..888,892..900,
                     907..909,916..921)
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320130"
     misc_feature    order(319..321,328..333,367..384,388..393,400..402,
                     532..534,538..552,622..624,631..639,643..651,655..660,
                     814..816,823..828,832..837,844..846,883..888,892..900,
                     907..909,916..921)
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320130"
     misc_feature    367..459
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320130"
     misc_feature    367..459
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320130"
     misc_feature    373..438
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    493..558
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320130"
     misc_feature    493..558
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320130"
     misc_feature    502..558
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    622..711
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320130"
     misc_feature    622..711
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320130"
     misc_feature    628..696
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    754..846
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320130"
     misc_feature    754..846
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320130"
     misc_feature    775..852
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     misc_feature    886..963
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320130"
     misc_feature    886..963
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320130"
     misc_feature    898..963
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /note="propagated from UniProtKB/Swiss-Prot (P49684.2);
                     transmembrane region"
     exon            1..1161
                     /gene="Uts2r"
                     /gene_synonym="Gpr14; Senr; UR-2-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctctga gcctggagtc tacaacaagc tttcatatgc tcaccgtgtc cggaagcact
       61 gtgactgagc tgcctggtga ctccaacgtg tccctcaaca gttcctggtc cggcccaaca
      121 gatcccagct ccctgaaaga ccttgtggcc acgggtgtca tcggggcagt gctctcagcc
      181 atgggtgtgg tgggcatggt gggaaatgta tacactttgg tggtcatgtg ccggtttctg
      241 cgtgcctcgg cctccatgta cgtctatgtg gtcaacctag cgctggctga tctgctgtac
      301 ctgctgagca ttcccttcat catagccacc tacgtcacta aggactggca ctttggagat
      361 gtgggctgca gagtcctctt tagcctggac ttcctgacaa tgcacgccag catcttcacc
      421 ctgaccataa tgagcagcga acgctatgca gccgtactga ggcctctgga cacagtccag
      481 cgctccaagg gttaccgtaa gctgctggtg ctgggcacct ggttgctggc actgctgctg
      541 accctaccca tgatgcttgc catccagctg gtccgcaggg gctctaagag cctctgcctg
      601 ccagcctggg gccctcgtgc ccaccgtact tacctaacgt tgctctttgg gaccagcatt
      661 gtggggcctg gcttggtcat tgggctgctc tatgtccgtc tggccagggc ctactggcta
      721 tctcagcaag cttctttcaa gcagacacgg cggctgccca accccagggt gctctacctc
      781 atccttggta tcgtccttct cttctgggcc tgctttctac ccttctggct gtggcagctg
      841 ctggcccagt accacgaggc catgccactg actcccgaga ctgcacgcat tgtcaactac
      901 ctgaccacct gcctcactta tggcaacagt tgcatcaatc ccttcctcta cactctgctc
      961 accaagaact atcgagagta cctacgtggc cgccagcggt cactgggtag tagttgccac
     1021 agcccaggga gtcctggcag cttcctgccc agccgagtcc acctccagca ggactcgggc
     1081 cgctcgctgt cctccagcag ccaacaggcc acagagaccc tcatgctgtc tccagtcccc
     1141 cgtaacgggg cccttctctg a
//
LOCUS       NM_053645               1245 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus interleukin 5 receptor subunit alpha (Il5ra),
            mRNA.
ACCESSION   NM_053645
VERSION     NM_053645.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Zhou,Y., Li,C., Li,D., Zheng,Y. and Wang,J.
  TITLE     IL-5 blocks apoptosis and tau hyperphosphorylation induced by
            Abeta25-35 peptide in PC12 cells
  JOURNAL   J Physiol Biochem 73 (2), 259-266 (2017)
   PUBMED   28132394
  REMARK    GeneRIF: Data suggest that IL5/IL5Ra signaling activates JAK2 in
            neurons down-regulating cell apoptosis and down-regulating
            hyperphosphorylation of Tau [up-regulated in Alzheimer disease via
            amyloid-beta(25-35) peptide]. [IL5 = interleukin-5 ; IL5Ra =
            interleukin-5 receptor, alpha subunit; JAK2 = Janus kinase 2]
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Wilson,T.M., Maric,I., Shukla,J., Brown,M., Santos,C., Simakova,O.,
            Khoury,P., Fay,M.P., Kozhich,A., Kolbeck,R., Metcalfe,D.D. and
            Klion,A.D.
  TITLE     IL-5 receptor alpha levels in patients with marked eosinophilia or
            mastocytosis
  JOURNAL   J Allergy Clin Immunol 128 (5), 1086-92 (2011)
   PUBMED   21762978
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Park,C.S.
  TITLE     Eosinophilic bronchitis, eosinophilia associated genetic variants,
            and notch signaling in asthma
  JOURNAL   Allergy Asthma Immunol Res 2 (3), 188-194 (2010)
   PUBMED   20592918
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Busse,W.W., Katial,R., Gossage,D., Sari,S., Wang,B., Kolbeck,R.,
            Coyle,A.J., Koike,M., Spitalny,G.L., Kiener,P.A., Geba,G.P. and
            Molfino,N.A.
  TITLE     Safety profile, pharmacokinetics, and biologic activity of
            MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study
            of subjects with mild asthma
  JOURNAL   J Allergy Clin Immunol 125 (6), 1237-1244 (2010)
   PUBMED   20513521
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Mao,H., Wen,F.Q., Liu,C.T., Liang,Z.A., Wang,Z.L. and Yin,K.S.
  TITLE     Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing
            vector on bone marrow eosinophilopoiesis in asthmatic mice
  JOURNAL   Adv Ther 23 (6), 938-956 (2006)
   PUBMED   17276963
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Gevaert,P., Bachert,C., Holtappels,G., Novo,C.P., Van der
            Heyden,J., Fransen,L., Depraetere,S., Walter,H., van Cauwenberge,P.
            and Tavernier,J.
  TITLE     Enhanced soluble interleukin-5 receptor alpha expression in nasal
            polyposis
  JOURNAL   Allergy 58 (5), 371-379 (2003)
   PUBMED   12752323
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Saito,H., Matsumoto,K., Denburg,A.E., Crawford,L., Ellis,R.,
            Inman,M.D., Sehmi,R., Takatsu,K., Matthaei,K.I. and Denburg,J.A.
  TITLE     Pathogenesis of murine experimental allergic rhinitis: a study of
            local and systemic consequences of IL-5 deficiency
  JOURNAL   J Immunol 168 (6), 3017-3023 (2002)
   PUBMED   11884474
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Pierrot,C., Begue,A., Szpirer,C., Capron,A., Capron,M. and
            Khalife,J.
  TITLE     Cloning of the rat IL-5Ralpha gene: analysis of 5'-upstream region
            and expression by B cells
  JOURNAL   Biochem Biophys Res Commun 288 (2), 328-339 (2001)
   PUBMED   11606047
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Tanaka,H., Kawada,N., Yamada,T., Kawada,K., Takatsu,K. and Nagai,H.
  TITLE     Allergen-induced airway inflammation and bronchial responsiveness
            in interleukin-5 receptor alpha chain-deficient mice
  JOURNAL   Clin Exp Allergy 30 (6), 874-881 (2000)
   PUBMED   10848907
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Denburg,J.A., Sehmi,R., Upham,J., Wood,L., Gauvreau,G. and
            O'Byrne,P.
  TITLE     Regulation of IL-5 and IL-5 receptor expression in the bone marrow
            of allergic asthmatics
  JOURNAL   Int Arch Allergy Immunol 118 (2-4), 101-103 (1999)
   PUBMED   10224351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB056101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB056101.1, AF324153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..1245
                     /gene="Il5ra"
                     /note="interleukin 5 receptor subunit alpha"
                     /db_xref="GeneID:114103"
                     /db_xref="RGD:70938"
     CDS             1..1245
                     /gene="Il5ra"
                     /note="interleukin 5 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-5 receptor subunit alpha precursor"
                     /protein_id="NP_446097.1"
                     /db_xref="GeneID:114103"
                     /db_xref="RGD:70938"
                     /translation="MVPVLLILMGASATLHADLLSPEKFLLLPPVNFTIKATGLAQVL
                     LHWDPNPDQDPVDLEYHVKINVPQEDEYDTKNTESKCVTPLHECFAASVRTILKSIHS
                     PLASSWVSAELKAPPGSSGTSVMNLTCTTNTVKSSHTHFRPYQVSLRCTWLVGKDAPE
                     DTQYFLYYRFSVWTEECQEYSRDALNRNIACWFPRTFINSKGFEQLAVHINGSSKHAA
                     TKPLDQLFTLYAIDQVNPPMNVTVEIENNSLYIQWGKPLSAFPVHCFKYKLKIYNTKN
                     GYSQMENLVTNKFISKIDDVSTYSIQVRAAVSSPCRMSGSWGEWSQPIYVGKKKKPLV
                     EWHLIVLPTAICFILLIFSLICRVYHLWTRLFPPVPAPKSSIKDLPVVTEYEKPPWNE
                     TKIEIVHFVEEDGFEVMENSLF"
     sig_peptide     1..51
                     /gene="Il5ra"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     52..1242
                     /gene="Il5ra"
                     /product="interleukin-5 receptor subunit alpha"
     misc_feature    376..693
                     /gene="Il5ra"
                     /note="Interleukin-6 receptor alpha chain, binding;
                     Region: IL6Ra-bind; pfam09240"
                     /db_xref="CDD:401252"
     misc_feature    376..693
                     /gene="Il5ra"
                     /note="Interleukin-6 receptor alpha chain, binding;
                     Region: IL6Ra-bind; pfam09240"
                     /db_xref="CDD:401252"
     exon            1..73
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            74..213
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            214..352
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            353..506
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            507..694
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            695..840
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            841..979
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1158
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1245
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgcctg tgttactaat tcttatggga gcttcggcaa cactgcatgc tgacttactt
       61 tctcctgaaa agtttttact tctgccacct gtcaatttta ccattaaagc caccggatta
      121 gctcaagttc ttttacactg ggacccaaat cctgaccaag atcctgtgga tctagagtac
      181 catgtgaaaa taaatgttcc acaagaagac gaatatgata ctaaaaatac tgaaagcaaa
      241 tgcgtgaccc cacttcatga atgctttgca gcgagtgtaa ggaccattct gaagagcatc
      301 cactctcccc tggccagcag ctgggtttct gctgaactca aagctccacc aggatcttct
      361 ggcacctcgg ttatgaattt aacttgtacc acaaacactg tcaaaagtag ccacacccac
      421 ttcaggccat accaagtttc tcttcgttgc acctggcttg ttggcaagga tgcccctgag
      481 gacacacagt atttcctata ctataggttt agtgtttgga ctgaagaatg ccaagaatac
      541 agcagagatg cactgaacag aaatattgca tgctggttcc ccaggacatt tatcaacagc
      601 aaagggtttg aacagcttgc tgtgcacatt aatggttcaa gcaagcacgc tgcaaccaag
      661 cccttggatc agctgttcac tctatatgcc attgatcaag tgaatcctcc aatgaatgtc
      721 acagtggaaa ttgaaaacaa ttctctctat atacaatggg gaaaaccact ttctgccttt
      781 ccagtccatt gctttaagta taaactgaaa atttacaaca caaaaaatgg ttactctcag
      841 atggaaaacc tggtcaccaa taagttcatc tcaaaaattg atgatgtttc tacatattcc
      901 attcaagtga gagcagctgt gagctcacct tgcaggatgt caggaagctg gggcgagtgg
      961 agtcaaccga tttatgtggg aaagaaaaag aagcccttgg tagaatggca tctcatcgtg
     1021 ctcccaacag ccatctgctt catcttgtta atcttctcac tcatctgcag agtgtatcac
     1081 ctatggacaa ggttgtttcc accagttccg gcgccaaaga gtagcatcaa agatctccct
     1141 gtggtgactg aatatgagaa acctccttgg aatgaaacca aaattgaaat cgtacatttt
     1201 gtagaagagg atggatttga agtcatggaa aattccctgt tttga
//
LOCUS       NM_001011697             585 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus Spetex-2B protein (Spetex2b), mRNA.
ACCESSION   NM_001011697
VERSION     NM_001011697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Iwamoto,Y., Kaneko,T., Ichinose,J., Mori,T., Shibata,Y.,
            Toshimori,K. and Iida,H.
  TITLE     Molecular cloning of rat Spetex2 family genes mapped on chromosome
            15p16, encoding a 23-kilodalton protein associated with the plasma
            membranes of haploid spermatids
  JOURNAL   Biol Reprod 72 (2), 284-292 (2005)
   PUBMED   15371276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB180077.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180077.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15"
     gene            1..585
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /note="Spetex-2B protein"
                     /db_xref="GeneID:497084"
                     /db_xref="RGD:1359347"
     CDS             1..585
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /codon_start=1
                     /product="Spetex-2B protein"
                     /protein_id="NP_001011697.1"
                     /db_xref="GeneID:497084"
                     /db_xref="RGD:1359347"
                     /translation="MFHQLLKLVQKERGDQGETRTRQKKAGLLSWFIRKASSENFISN
                     HEKRIKKLEEVKSEIQKCKIEGDELSRILDLYVNDGLNYRLNIELPMLKSQHEMRTMD
                     MHKMTNWISDAMEKYKELTQENNSYRIRNFHLLNERNELKKNVRILMNENRKLLVEQT
                     ELQASCEEGKRFCEEASKTIYTADIESLCPVTFE"
     misc_feature    100..342
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    100..342
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            1..91
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /inference="alignment:Splign:2.1.0"
     exon            92..251
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /inference="alignment:Splign:2.1.0"
     exon            252..383
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /inference="alignment:Splign:2.1.0"
     exon            384..585
                     /gene="Spetex2b"
                     /gene_synonym="Spetex-2B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttcacc agctgctcaa gctagttcag aaggagaggg gagaccaagg agagaccaga
       61 acgaggcaga agaaagctgg cctcctgtct tggtttattc ggaaggcatc atcagaaaat
      121 ttcatcagta accatgaaaa gcgtataaag aaattggagg aagtaaaatc tgaaatccag
      181 aagtgtaaaa tcgaggggga tgaactttct cgaatcctgg acctttatgt caatgatggt
      241 ttgaactaca ggctgaacat tgaattgcca atgcttaaat cccaacatga gatgagaacg
      301 atggatatgc ataagatgac caactggata agtgatgcca tggagaagta caaggagctc
      361 acacaagaga acaattccta ccgcatcaga aacttccacc tcctgaatga acgcaatgaa
      421 ttgaagaaga atgtaaggat tttgatgaat gagaacagaa aactgctggt ggagcagact
      481 gaactgcaag catcctgtga ggagggaaag aggttctgtg aggaggccag caagaccatc
      541 tacaccgcag atattgaatc cttgtgtcct gttacttttg agtaa
//
LOCUS       NM_001109088            1778 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 30 member 9 (Slc30a9),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001109088 XM_001057251 XM_001070327
VERSION     NM_001109088.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Yu,G., Zhu,Y., Song,C., Chen,L., Tang,Z. and Wu,T.
  TITLE     The ZIP9-centered androgen pathway compensates for the 2605 MHz
            radiofrequency electromagnetic radiation-mediated reduction in
            resistance to H2O2 damage in Sertoli cells of adult rats
  JOURNAL   Ecotoxicol Environ Saf 254, 114733 (2023)
   PUBMED   36889209
  REMARK    GeneRIF: The ZIP9-centered androgen pathway compensates for the
            2605 MHz radiofrequency electromagnetic radiation-mediated
            reduction in resistance to H2O2 damage in Sertoli cells of adult
            rats.
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Perez,Y., Shorer,Z., Liani-Leibson,K., Chabosseau,P., Kadir,R.,
            Volodarsky,M., Halperin,D., Barber-Zucker,S., Shalev,H.,
            Schreiber,R., Gradstein,L., Gurevich,E., Zarivach,R., Rutter,G.A.,
            Landau,D. and Birk,O.S.
  TITLE     SLC30A9 mutation affecting intracellular zinc homeostasis causes a
            novel cerebro-renal syndrome
  JOURNAL   Brain 140 (4), 928-939 (2017)
   PUBMED   28334855
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Chen,Y.H., Kim,J.H. and Stallcup,M.R.
  TITLE     GAC63, a GRIP1-dependent nuclear receptor coactivator
  JOURNAL   Mol Cell Biol 25 (14), 5965-5972 (2005)
   PUBMED   15988012
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Sim,D.L. and Chow,V.T.
  TITLE     The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and
            encodes a nuclear protein containing the nuclear receptor
            interaction motif
  JOURNAL   Genomics 59 (2), 224-233 (1999)
   PUBMED   10409434
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473981.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070327.1, XM_001057251.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1778
                     /gene="Slc30a9"
                     /note="solute carrier family 30 member 9"
                     /db_xref="GeneID:498358"
                     /db_xref="RGD:1593180"
     exon            1..177
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    45..47
                     /gene="Slc30a9"
                     /note="upstream in-frame stop codon"
     CDS             75..1778
                     /gene="Slc30a9"
                     /note="zinc transporter 9; solute carrier family 30 (zinc
                     transporter), member 9"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A9,
                     mitochondrial"
                     /protein_id="NP_001102558.1"
                     /db_xref="GeneID:498358"
                     /db_xref="RGD:1593180"
                     /translation="MFPGLAAAAAAHRCSWAALCRLGGGPAVARGRSQGWKNLMTFES
                     FTSMIPSIHPQISVLNQVKLYSTNVQKGGQGSQTPRTDKAPPLTQAAENIGAELKAPL
                     KQDPLQVRVKAVLKKREYGSKYTKNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHDD
                     TESFTVFLRSDVEAKALEVWGSLEALAREKKLRKEAEIEYRERLFRNQRILREYGDFL
                     GNTKPRSRAISVFLKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT
                     CNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGIMGLLH
                     PQPMESLLWAYCILAGSLVSEGATLLVAINELRRSAQANGTSFYKYVMESRDPSTNVI
                     LLEDTAAVLGVMIAATCMGLTSITGNPLYDSLGSLGVGTLLGVVSAFLISTNIEALLG
                     RSIQPEQVQRLTELLESDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQ
                     DFDQMMQEIEEVKTPEQLEAFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEI
                     L"
     misc_feature    453..716
                     /gene="Slc30a9"
                     /note="N-terminal domain found in zinc transporter 9
                     (ZNT9) and similar proteins; Region: NTD_ZNT9; cd21078"
                     /db_xref="CDD:410964"
     misc_feature    453..716
                     /gene="Slc30a9"
                     /note="N-terminal domain found in zinc transporter 9
                     (ZNT9) and similar proteins; Region: NTD_ZNT9; cd21078"
                     /db_xref="CDD:410964"
     misc_feature    783..1760
                     /gene="Slc30a9"
                     /note="Divalent metal cation (Fe/Co/Zn/Cd) efflux pump
                     [Inorganic ion transport and metabolism]; Region: FieF;
                     COG0053"
                     /db_xref="CDD:439823"
     misc_feature    783..1760
                     /gene="Slc30a9"
                     /note="Divalent metal cation (Fe/Co/Zn/Cd) efflux pump
                     [Inorganic ion transport and metabolism]; Region: FieF;
                     COG0053"
                     /db_xref="CDD:439823"
     exon            178..345
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            346..405
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            406..505
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            506..598
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            599..681
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            682..740
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            741..808
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            809..911
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            912..967
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1143
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1215
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1323
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1489
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1619
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1733
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1778
                     /gene="Slc30a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtcag ttggcacggc aggtagctcg gaggcaggag gcggtgaccg agttggggcc
       61 tctgccccgc caggatgttt ccgggcttgg ccgccgccgc tgcggcgcac aggtgcagct
      121 gggcggcgct gtgcaggctc ggtggcggcc cggcagtagc ccgcggccgc agccagggat
      181 ggaagaattt aatgacattt gaaagcttta cgtccatgat tcccagcatt cacccgcaaa
      241 tatctgttct aaatcaagtc aagttgtact ctacaaatgt ccagaaagga gggcagggct
      301 cacaaactcc gagaactgac aaagccccac cgcttacgca agcagcagaa aatataggtg
      361 cagaactcaa agctccactt aagcaagatc ctctccaagt cagagtcaaa gcagtcctta
      421 agaaaaggga gtatggatca aaatacacta agaataattt catcactgga gtaagagcaa
      481 tcaatgagtt ctgccttaag tccagtgatt tagaacaact tcgaaaaatc aggcgacgaa
      541 gtccccacga tgacactgag tcctttactg tgttcttgag gtcagatgtg gaagcaaaag
      601 ctctggaagt ttggggaagc cttgaagctc ttgccagaga gaaaaaattg cgtaaagaag
      661 cagagataga atacagagaa cggctgttta gaaaccaaag aatactaaga gaatatggtg
      721 atttcttggg aaacacaaag ccacgctcca gagcgatctc agtgttcctt aagggaccag
      781 gaaaggtggt gatggtcgct atttgcatta atggcttaaa ctgcttcttt aaatttcttg
      841 cctggattta tacgggttca gcaagtatgt tctcagaagc tatacattca ttatctgata
      901 cttgtaacca gggtttgcta gcactgggca tcagcaagtc tgttcaaaca ccagatcctt
      961 ctcacccgta tggcttttca aatatgcgct atatttcttc attgattagt ggtgttggta
     1021 ttttcatgat gggcgcagga ctctcttggt atcatggaat catgggattg cttcatcctc
     1081 aaccaatgga atcccttcta tgggcatatt gtattttagc aggatctttg gtgtctgaag
     1141 gagcaacact tctcgttgcc ataaatgaac ttcgcaggag cgctcaagcg aatgggacat
     1201 cattttataa gtatgtcatg gagagtcgtg atccgagtac aaatgttatt ctattggagg
     1261 acactgcggc tgtcctagga gtgatgatag cagctacctg catgggcctt acctccataa
     1321 caggcaatcc attgtatgac agcctgggtt ccttgggtgt aggcacctta ctaggtgtgg
     1381 tctcggcatt cctcatctct accaacatag aagcactcct aggacgatcc atccaaccag
     1441 agcaagtaca gcggcttacc gaacttctgg agagcgaccc atcagtaagg gcaatccatg
     1501 atgtcaaagc cacagacctg ggattaggga aagtcagatt taaggcagaa gttgattttg
     1561 atggacgtgt tgttacaaga tcatatttgg aaaagcaaga ttttgaccaa atgatgcaag
     1621 agatcgaaga agtgaaaact cctgaacaat tagaagcctt tatgcttaaa catggagaaa
     1681 atattattga tactctagga gctgaagtag acaggcttga gaaagagctg aaaaaacgaa
     1741 accctgaagt tcggcacgtg gatcttgaga tcttatag
//
LOCUS       NM_012646               1179 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus RT1 class Ib, locus N1 (RT1-N1), mRNA.
ACCESSION   NM_012646
VERSION     NM_012646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1179)
  AUTHORS   Kirisits,M.J., Kunz,H.W., Hassett,A.L. and Gill,T.J. 3rd.
  TITLE     Genomic DNA sequence and organization of a TL-like gene in the
            grc-G/C region of the rat
  JOURNAL   Immunogenetics 35 (6), 365-377 (1992)
   PUBMED   1349585
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M74822.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="R21"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1179
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="RT1 class Ib, locus N1"
                     /db_xref="GeneID:24748"
                     /db_xref="RGD:3498"
     CDS             1..1179
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="RT1 class Ib gene H2-TL-like grc region; RT1 class
                     Ib gene, H2-TL-like, grc region (N1)"
                     /codon_start=1
                     /product="RT1 class Ib, locus N1 precursor"
                     /protein_id="NP_036778.1"
                     /db_xref="GeneID:24748"
                     /db_xref="RGD:3498"
                     /translation="MLWVPKAGALWLSALLLLLNACFSWTWTPEGSHSLRYFSIVMSW
                     LGLREPRIIVSGCIDDTEFVRLDTNKETVSLKPLVPWQEQEGLEYWEQQVHKVKTQEQ
                     QSARNLMMLVRFYNKSMDDFHTLQWQQGCDVGSDGRLLHWYDQLAFDGVDHPTLNKDL
                     RFWTAWTSTVAQISQPELEARLKDNCSELLQKYPEKEKERLLRSDPPRAHVTRQPRPE
                     GDVTLRCWALGFYPADITLTWQLNGEDLIQEMEFVETRPAGDGTFQKWASVVVPLGKE
                     QKYTCLVEHEGLSEPLTLRWEPAQDSTTTIILIILPTVSAIVLCVAAAAAICICLKKK
                     AGERGRHDTQEADGDSPQDSCRIVVDDQEIEGPSWNTENYRTHLGFHSGTLGLLSLSF
                     "
     sig_peptide     1..90
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="putative"
     mat_peptide     91..1176
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /product="RT1 class Ib, locus N1"
     misc_feature    91..603
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    91..603
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    604..894
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    604..894
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    661..675
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    661..675
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    706..720
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    706..720
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    832..849
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    832..849
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    877..888
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    877..888
                     /gene="RT1-N1"
                     /gene_synonym="MHTLL"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
ORIGIN      
        1 atgctctggg ttcccaaggc tggtgcgctc tggctcagtg cccttctcct gctcctgaat
       61 gcctgcttct cctggacttg gacccctgag ggctcacact ccctgcggta tttctccatt
      121 gtcatgtcct ggctgggcct ccgggagcca cggatcatag tcagcggctg catagatgat
      181 acggagttcg tgcgcttgga caccaacaag gagactgtaa gcctgaagcc cctagtgcct
      241 tggcaggagc aggaggggct agagtactgg gagcagcagg ttcataaagt caagactcaa
      301 gaacaacagt ctgcaaggaa cctgatgatg ctggttcgtt tttacaataa gagcatggac
      361 gacttccaca cactacagtg gcagcaaggc tgcgatgtgg ggtcagatgg gcgcctgctt
      421 cactggtacg accagctcgc ctttgatggt gtagatcacc ccaccctgaa caaagacctg
      481 cgtttctgga cagcgtggac cagcactgta gctcagatat ctcagcccga gttagaagct
      541 cgcctgaagg acaactgctc agagctgctg cagaaatacc cagaaaagga gaaggagagg
      601 ctgctgcgtt cagacccgcc aagggcacat gtgacccggc aacccagacc tgaaggtgat
      661 gtcaccctga ggtgctgggc cctgggtttc taccctgctg acatcaccct gacctggcag
      721 ttgaatgggg aggacctgat ccaagaaatg gagtttgtgg agaccaggcc tgcaggggat
      781 ggaaccttcc agaagtgggc atctgtggtg gtgcctctag ggaaggagca gaagtacaca
      841 tgccttgtgg agcatgaggg gctgtcagag ccgctcaccc tgagatggga gcctgcccag
      901 gattccacca ctacaatcat tctaattatt ctacccactg tctctgcaat tgtcctctgt
      961 gttgctgctg ctgcggcaat ttgcatatgc ctgaagaaga aggcaggtga aagaggaagg
     1021 cacgacaccc aggaagcaga tggagacagt ccccaagact cttgcaggat tgttgtggat
     1081 gatcaggaga tcgagggtcc ctcttggaat actgagaact acagaactca tctaggattc
     1141 cactctggga ctttaggatt gcttagcttg tcattttaa
//
LOCUS       NM_213731                966 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus olfactory receptor family 12 subfamily D member
            17 (Or12d17), mRNA.
ACCESSION   NM_213731
VERSION     NM_213731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL603724.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..966
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="olfactory receptor family 12 subfamily D member 17"
                     /db_xref="GeneID:408030"
                     /db_xref="RGD:1303153"
     CDS             1..966
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="olfactory receptor 29; olfactory receptor 1868"
                     /codon_start=1
                     /product="olfactory receptor family 12 subfamily D member
                     17"
                     /protein_id="NP_998896.1"
                     /db_xref="GeneID:408030"
                     /db_xref="RGD:1303153"
                     /translation="MENSTSVDEFLLLGLTTVQKLQPIFFVMFLTIYLLNLVGNGVIL
                     MIVTLERRLHSPMYFFLGNLSCLDICYSSVTLPKVLINLLSRHRTISFLGCITQLYFF
                     HFLGSTEAILLAVMAFDRFVAICSPLRYTAIMNPQLCILLAATAWLTSFFYALLHSVM
                     TAHLNFCHSHKLSHFFCDVKPLLEVACGSTVLNQWLLSVVTGSISMGAFLLIVLSYFY
                     IIAFLLFKNRSCRMLRKALSTCTSHFMVVCLFYGPVGFTYIRPATASASSMSEDRMVA
                     IIYSAVTPVLNPLIYTLRNKEVMLALKRNFGKKLFKDNQLHAGDQ"
     misc_feature    67..885
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="olfactory receptor subfamily 12D and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR12D-like; cd15915"
                     /db_xref="CDD:320581"
     misc_feature    67..885
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="olfactory receptor subfamily 12D and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR12D-like; cd15915"
                     /db_xref="CDD:320581"
     misc_feature    70..150
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320581"
     misc_feature    70..150
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320581"
     misc_feature    169..249
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320581"
     misc_feature    169..249
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320581"
     misc_feature    order(235..237,244..249,283..300,304..309,316..318,
                     451..453,457..471,577..579,586..594,598..606,610..615,
                     751..753,760..765,769..774,781..783,805..810,814..822,
                     829..831,838..843)
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320581"
     misc_feature    order(235..237,244..249,283..300,304..309,316..318,
                     451..453,457..471,577..579,586..594,598..606,610..615,
                     751..753,760..765,769..774,781..783,805..810,814..822,
                     829..831,838..843)
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320581"
     misc_feature    283..375
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320581"
     misc_feature    283..375
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320581"
     misc_feature    412..477
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320581"
     misc_feature    412..477
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320581"
     misc_feature    577..669
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320581"
     misc_feature    577..669
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320581"
     misc_feature    691..783
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320581"
     misc_feature    691..783
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320581"
     misc_feature    808..885
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320581"
     misc_feature    808..885
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320581"
     exon            1..966
                     /gene="Or12d17"
                     /gene_synonym="MOR250-1; Olr1868; Or29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagaact ccacttcagt ggatgagttc ctcttgcttg gcctgaccac tgttcagaaa
       61 ctgcagccca tcttttttgt gatgttttta accatttact tgctgaattt ggttggaaat
      121 ggagtaatat taatgatcgt tactctggag agaagacttc actccccgat gtacttcttc
      181 ctaggaaacc tttcctgcct ggatatttgt tactcttcgg tgactcttcc caaggttctc
      241 atcaaccttc tctcaaggca taggaccata tctttcctag gctgtatcac tcagctatat
      301 ttcttccact ttctgggaag cacggaggcc atcttgctgg ctgtgatggc ctttgaccgt
      361 tttgtagcca tctgcagccc actccgctac actgctatca tgaatcctca gttgtgcatc
      421 ctgttggcag ctacagcctg gctcactagc tttttctatg ctctgctgca ttctgtcatg
      481 actgctcact tgaatttctg ccactctcac aaactcagtc acttcttctg tgatgtcaaa
      541 cctctcttag aagtggcctg tggcagcaca gtactcaacc agtggcttct ttctgttgtc
      601 acaggcagta tatccatggg ggccttcctc ctcatagtcc tctcctattt ctacatcatt
      661 gcttttcttc tgttcaagaa caggtcctgc agaatgctta ggaaggctct gtccacttgc
      721 acctctcact ttatggtggt ttgtcttttc tatggacctg ttggtttcac atacatccgt
      781 cctgccacag catcagcgtc ctccatgagt gaggatcgga tggtggccat catctatagt
      841 gcagtcaccc cagtgctgaa cccattgata tatactctta ggaacaaaga ggtgatgttg
      901 gctctgaaaa ggaactttgg gaagaagttg tttaaagaca accagctaca tgcaggagat
      961 caatga
//
LOCUS       NM_001256149             300 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus prostate and testis expressed 14-like 2
            (Patel14l2), mRNA.
ACCESSION   NM_001256149 XM_002727029 XM_002729934
VERSION     NM_001256149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from HQ840742.1.
            
            On or before Jan 9, 2012 this sequence version replaced
            XM_002727029.1, XM_002729934.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ840742.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..300
                     /gene="Patel14l2"
                     /note="prostate and testis expressed 14-like 2"
                     /db_xref="GeneID:100362690"
                     /db_xref="RGD:2324268"
     CDS             1..300
                     /gene="Patel14l2"
                     /note="spleen protein 3; secreted seminal-vesicle Ly-6
                     protein 1-like; rCG64164-like"
                     /codon_start=1
                     /product="Secreted seminal-vesicle Ly-6 protein 1-like
                     precursor"
                     /protein_id="NP_001243078.1"
                     /db_xref="GeneID:100362690"
                     /db_xref="RGD:2324268"
                     /translation="MGKHFLLFLLGLSFVVGFLQALTCWDCDMLNSDGICEKGYSTCK
                     SKDDQECGKLVVSTGDKILYWMQDCSSMCLNKTFTHSHLTLNFTCCHDQSLCNEF"
     sig_peptide     1..63
                     /gene="Patel14l2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    58..294
                     /gene="Patel14l2"
                     /note="three-fingered protein (TFP) fold found in Ly6/uPAR
                     (LU) and snake toxin superfamily; Region: TFP; cl45932"
                     /db_xref="CDD:480272"
     misc_feature    58..294
                     /gene="Patel14l2"
                     /note="three-fingered protein (TFP) fold found in Ly6/uPAR
                     (LU) and snake toxin superfamily; Region: TFP; cl45932"
                     /db_xref="CDD:480272"
     exon            1..61
                     /gene="Patel14l2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..175
                     /gene="Patel14l2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..300
                     /gene="Patel14l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaaaac acttcctgct gttcctgttg gggctctcct ttgtggtggg cttcctacaa
       61 gctttgacat gttgggactg tgacatgtta aactctgatg gaatttgtga gaaaggatac
      121 tctacctgta aatctaaaga tgaccaggaa tgtggcaaac tggtagtgtc tacaggtgat
      181 aaaatcctgt attggatgca agactgttca tccatgtgct tgaataagac attcacccat
      241 tcccatctaa cattgaattt tacatgttgc catgaccaat cactctgcaa tgagttttag
//
LOCUS       NM_001437332            3476 bp    mRNA    linear   ROD 02-APR-2025
DEFINITION  Rattus norvegicus SEH1-like nucleoporin (Seh1l), transcript variant
            2, mRNA.
ACCESSION   NM_001437332 XM_056984932
VERSION     NM_001437332.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3476)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 3476)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   3  (bases 1 to 3476)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3476)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   5  (bases 1 to 3476)
  AUTHORS   Ahn,S.H., Deshmukh,H., Johnson,N., Cowell,L.G., Rude,T.H.,
            Scott,W.K., Nelson,C.L., Zaas,A.K., Marchuk,D.A., Keum,S.,
            Lamlertthon,S., Sharma-Kuinkel,B.K., Sempowski,G.D. and Fowler,V.G.
            Jr.
  TITLE     Two genes on A/J chromosome 18 are associated with susceptibility
            to Staphylococcus aureus infection by combined microarray and QTL
            analyses
  JOURNAL   PLoS Pathog 6 (9), e1001088 (2010)
   PUBMED   20824097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3476)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   7  (bases 1 to 3476)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   8  (bases 1 to 3476)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 2, 2025 this sequence version replaced XM_056984932.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2113785.1,
                                           SRR26360190.3024161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000018.1  63616923-63617115
            194-244             JAXUCZ010000018.1  63621318-63621368
            245-391             JAXUCZ010000018.1  63624767-63624913
            392-603             JAXUCZ010000018.1  63626014-63626225
            604-702             JAXUCZ010000018.1  63628455-63628553
            703-843             JAXUCZ010000018.1  63632848-63632988
            844-1001            JAXUCZ010000018.1  63633520-63633677
            1002-1152           JAXUCZ010000018.1  63636252-63636402
            1153-3476           JAXUCZ010000018.1  63637529-63639852
FEATURES             Location/Qualifiers
     source          1..3476
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3476
                     /gene="Seh1l"
                     /note="SEH1-like nucleoporin"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
     exon            1..193
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1168
                     /gene="Seh1l"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleoporin SEH1; nucleoporin SEH1-like"
                     /codon_start=1
                     /product="nucleoporin SEH1 isoform 2"
                     /protein_id="NP_001424261.1"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
                     /translation="MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSES
                     GDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSH
                     WVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRVYEAPDVMNLSQWSLQHEIS
                     CKLCCSCISWNPSSSRAHPPMIAVGSDDSSPNSMAKVQIFEYNENTRKYAKAETLMTV
                     TDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDN
                     HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQLGN
                     STPSLSSNIPNLQNSLNGTSAGSRKHS"
     misc_feature    <113..1066
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <113..1066
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    125..247
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    125..247
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    263..415
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    263..415
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    428..529
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    428..529
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    578..718
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    578..718
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    746..883
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    746..883
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1042
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1042
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            194..244
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            245..391
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            392..603
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            604..702
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            703..843
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1001
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1152
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..3476
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgtgcct ctgccgcggt ccgggggctg cgggccgcac cgccgccctc tcggaggcgg
       61 gcccgggcag acggcggcgg ccatgtttgt ggcgcgcagc atcgcggcgg accacaagga
      121 cctcatccac gatgtgtctt tcgacttcca cgggcgccgg atggccacct gttccagcga
      181 ccagagcgtc aaggtgtggg ataagagcga gagcggagat tggcactgca cagctagttg
      241 gaagacacat agtggatctg tatggcgtgt gacatgggct catcctgagt ttggacaagt
      301 tttggcttcc tgttcttttg accgaacagc agccgtatgg gaagaaatag taggagagtc
      361 aaacgataaa cttcgaggac agagtcactg ggtgaaaagg acaactctag tggacagcag
      421 aacatctgtt acagatgtga aatttgctcc caagcacatg ggtctgatgt tagcaacctg
      481 ctctgcagat ggcatcgtga gagtctacga ggccccagat gtgatgaacc tcagccagtg
      541 gtccctgcag cacgagatct cgtgtaagct gtgctgcagc tgcatttctt ggaacccttc
      601 cagctctcgt gctcaccccc ccatgatcgc tgtgggaagt gatgacagca gtccaaattc
      661 aatggccaag gttcagatct ttgagtacaa tgaaaacacc aggaaatatg caaaagctga
      721 gactcttatg acagtcacgg atcctgtcca tgacattgcg tttgctccaa atttgggacg
      781 atctttccac atcctggcaa tagcaaccaa agatgtaaga attttcacat taaaacctgt
      841 gaggaaagaa cttacttctt ctggtggtcc aacaaaattt gaaatccata ttgtggctca
      901 gtttgataat cataattctc aggtctggag ggtgagttgg aacataacag gaacagtatt
      961 ggcgtcttca ggagatgacg gctgtgttag gttgtggaaa gctaattaca tggacaattg
     1021 gaagtgcact ggtattttga aaggtaacgg gagcccagta aatgggagtt ctcagctggg
     1081 aaactcaact ccttcactga gctcaaatat tccaaatctt caaaattcat taaatggaac
     1141 atctgctggc agcagaaagc acagctgagt gcacgctagc tggagtgact gtgctgctgt
     1201 gctgcttgtt gcatgcacac aggaatggaa accaacttct ttccctcccc agcgccgtgt
     1261 gatctccacg atgcaccagc agcctgttca ctactacaca caggcccaaa ggcctttaaa
     1321 tgacagtgta tataacttct gtactagtca gactcctgac actataaatg gaaaggcttt
     1381 ttgttgacat atcatcacca aaacaatttt ttggaatgtt ctggagacta acttgggttt
     1441 aaaaactgaa aagattgcta ttatcctcat aagcagttgg gaggagggca aatataattt
     1501 tattccattt ggaaaatata ggaatatgtc ttttattttc taaaacaata agctaaaatg
     1561 atgagttttt ataattttaa tttgaaaaat caaataaata ttttcataaa gattgttttg
     1621 agtggtaatg tgtttacctt ttgtagaatt gctctgtagg tgacattatc cacacaacta
     1681 ctttacaggt gacattatcc acacaactac atctcttgta attaaaatac tagtacagga
     1741 acagatcagt aacgtggcac cagttgagct caaatagttt gtagccaagc agcacattag
     1801 caattgctgg ttttattggt agtaaaatgg tgacagcact tctaagtttt catctcatat
     1861 tcaggagatg gctgtttcta atctatgcat gaatgtttat ggtgtgatcc tatacaactt
     1921 ggtttccttt aagacaattt ggaaacatga gttgacattt ttcagaaaat gtgcgtgcag
     1981 ttaaaattcc gtgtctcagg atttttaatg tgttatttca aagagtccct gtattctgaa
     2041 acttttgact ttgatgatag ttatacacct tttcacttac taaactgcat acatattacg
     2101 ggtaagttat gagatggtag aataacaggc tataattctt tgagcctttt tatgcaccaa
     2161 aattctgtag gtattctaag ttttttgcag gaaacgaagc ctgtgcaatg attgtatttc
     2221 tcaagcatgt ggagtgcagt agccaggtct cccggtagtg agttggagct ggttctcggt
     2281 atcatgtatg cactaacgtg tgcctgctgc tgtaacacat gcagctctgc tggaaaggaa
     2341 gagcagatgt gtgaattaag gaatcaaatg agattagaca cgctttcagt ttataaaatg
     2401 aatgtctctg taacatacgt cctgatgatt ttgggggcat tttaacttta acagattgta
     2461 ttttttttta aaatttttat acttcttaag cagccttgat tcaagtgaga gtcttgattt
     2521 gtactgttct atcggttgtg gcatgaatat acagcttttt ttccttcctt ccagcatgtt
     2581 ttctcttctt tggttctctt tgtatttact gcttttctct ttttcttctg tttccctccc
     2641 tcctttcccc ctgttgtttt tgttttggtg ttttgttcct gtcttcatta tttcaggtat
     2701 ttctttcccc ctctggattc cccacgggct ggatcaagat ggtccagctg tgcccagctc
     2761 cttcctcctc ctgctcctct gctagagcac tcttgtgatg cagacactgc caacctccac
     2821 tatcctcacc ctcgcagagg atgcctctct cggcctctta atcccttacc tgagaatgaa
     2881 ggggtgtaaa atcctgattt aaaggcctta cccagatgct tgtaaatgct tttattccgg
     2941 gctgcttttg gtttcttcat tttcttttag aagatccttc ctagttaggc catgtcttgc
     3001 atgtatcaca actcgagtgt ttgaaaccaa acctgtttgt acttctgcac caggaaacct
     3061 tggcttcact agttggttac cttggacgag atgagcttca gaaaaagcaa tattaactgt
     3121 gaacgattcc cagtatctgg ttcaaagtgc ctgtcttgta cattcattct gtgtggactt
     3181 gttatcatag agttcagttt tgtctgttga tggtagcttc agaggaaagc atatcattgt
     3241 gaacttcact ctgtaattca gacattaaga aatgtttgga attttatagg ctgatgttac
     3301 aaatgactgt aaaataaatc attcctgtgt ataaagcagc aaatcataag gatatttttg
     3361 tctttttttt ttttttttaa aggaaaatgc cttttactac ttggaattac tacttaaaaa
     3421 ttttgtaact gttctccaag taggttattt aataaaagta ttttaaaaga tgtgaa
//
LOCUS       NM_001437217            2886 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            2, mRNA.
ACCESSION   NM_001437217 XM_006249118
VERSION     NM_001437217.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2886)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2886)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2886)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2886)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2886)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2886)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2886)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2886)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249118.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000012.1  24761299-24761362   c
            65-111              JAXUCZ010000012.1  24761121-24761167   c
            112-165             JAXUCZ010000012.1  24760247-24760300   c
            166-412             JAXUCZ010000012.1  24759745-24759991   c
            413-590             JAXUCZ010000012.1  24759477-24759654   c
            591-731             JAXUCZ010000012.1  24756632-24756772   c
            732-843             JAXUCZ010000012.1  24756440-24756551   c
            844-966             JAXUCZ010000012.1  24756223-24756345   c
            967-1083            JAXUCZ010000012.1  24754191-24754307   c
            1084-1223           JAXUCZ010000012.1  24753946-24754085   c
            1224-1387           JAXUCZ010000012.1  24752946-24753109   c
            1388-1507           JAXUCZ010000012.1  24751630-24751749   c
            1508-1590           JAXUCZ010000012.1  24749484-24749566   c
            1591-1654           JAXUCZ010000012.1  24749332-24749395   c
            1655-1722           JAXUCZ010000012.1  24749165-24749232   c
            1723-1799           JAXUCZ010000012.1  24749003-24749079   c
            1800-1884           JAXUCZ010000012.1  24748839-24748923   c
            1885-2112           JAXUCZ010000012.1  24748522-24748749   c
            2113-2253           JAXUCZ010000012.1  24748072-24748212   c
            2254-2886           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2886
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..64
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    19..21
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="upstream in-frame stop codon"
     exon            65..111
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            112..165
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2529
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424146.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    199..210
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    205..264
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    376..438
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    547..>708
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    547..>708
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    748..1320
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    748..1320
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    835..837
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(1024..1026,1066..1077,1081..1083,1093..1104,
                     1111..1113,1117..1125)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1024..1026,1066..1077,1081..1083,1093..1104,
                     1111..1113,1117..1125)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1096..1098,1114..1116)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1096..1098,1114..1116)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1111..1113,1120..1122)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1111..1113,1120..1122)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1123..1125,1129..1131,1141..1146)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1123..1125,1129..1131,1141..1146)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1132..1134
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1342..2043
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1342..2043
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1363..1365,1369..1371,1378..1380,1384..1389,
                     1393..1395,1525..1527,1531..1533,1582..1584,1591..1617)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1363..1365,1369..1371,1378..1380,1384..1389,
                     1393..1395,1525..1527,1531..1533,1582..1584,1591..1617)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1735..1737
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2122..2496
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2122..2496
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            166..412
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..590
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..731
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..843
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..966
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1083
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1223
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1387
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1507
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1590
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1654
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1722
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1799
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1884
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2112
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2253
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2886
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acagctgcgg gtcctgggat cttcagcgcg gcttggattt caaactggag gggttcagga
      121 gggggcacaa gcatggaaca acgttggggt ctacttcgga aagtgcaaca gtggtcccca
      181 agaccctctc agaccatcta cagacgtgtg gaaggccctc aactggagaa cctagaggag
      241 gaagataggg aggaagggga ggagcttcct gcccagttct gccccatgga actcaaaggc
      301 cctgagcgct taggctcctg tcctgggagg tccattccca taccctgggc tgcagcaggt
      361 cgaaaggctg ctccctatct ggtcctgacc accctgctaa tcttcactgg ggccttcctc
      421 ctgggctacg tggcctttcg agggtcctgc caggcatgtg gggactctgt gttggtggtt
      481 ggtgaagatg tcaactctga ggactccagc cggggcacgt tgtactggag tgacctccag
      541 gacatgtttc tccggttcct tggggaggga cgcatggagg acaccatcag gctgaccagc
      601 ctccgggaac gcgtggccgg ctcagccaga atggccaccc tggtccaaga catcctcgat
      661 aagctctcgc gccagaagct ggaccacgtg tggactgaca cgcactatgt gggacttcag
      721 ttcccggacc cggctcaccc taacaccctg cactgggtgg gtgcagacgg gagcgtccaa
      781 gagcagctac cgctggagga tccggaagtc tactgtccct acagcgccac gggcaacgcc
      841 acgggcaagc ttgtgtacgc ccactacggg cggcgggagg acctgcagga cctgaaagcc
      901 aaggacgtgg agctggccgg cagcctcctg ctagtgcgtg ctgggattac aagcttcgcc
      961 cagaaggtag ccattgccca ggactttggg gcccacggag tgctgatata ccctgaccca
     1021 gcggacttct cccaagaccc ccacaagcca ggcctgtcta gtgacagggc tgtgtatgga
     1081 catgtgcacc tgggaactgg ggacccttac acgcctggct tcccgtcctt caatcaaacc
     1141 cagttccctc cagtagaatc atcggggctt cccaacatcc ctgcccagcc catcagtgcc
     1201 gacgttgctg atcgcttgct caggaaactc acaggtcccg tggctcctca ggaatggaag
     1261 ggtcgcctct cagactctcc gtatcgcctg ggacctgggc caggcttacg ccttgtggtc
     1321 aacaaccaca gaacctctac tcccatcagt aacatctttg cgtgcatcga gggcttcgca
     1381 gagccagatc actatgtcgt tatcggggcc cagagggatg cctggggccc aggagcagcc
     1441 aagtctgcag tggggactgc catcctcctg gagctggttc ggaccttttc ctccatggtc
     1501 agcagtggct ttagacctcg aagaagtctt ttgttcatca gctgggacgg aggtgacttt
     1561 ggcagcgtgg gagccacgga gtggttggag ggctacctca gcgtgctaca cctcaaagct
     1621 gtcgtgtatg tgagcctgga caactccgtg ttgggagacg gcaaattcca tgctaagacc
     1681 agcccccttc tcgtcagcct cattgagaat atcctgaagc aggtggattc ccctaaccac
     1741 agtggacaga cactctacga tcaagtggca ttcacccacc caagctggga tgctgaagtg
     1801 atccagcccc tgcccatgga cagcagcgca tattccttca cagcttttgc gggcgtccca
     1861 gctgtggagt tctccttcat ggaggacgat agggtgtacc cattcctgca cacgaaggag
     1921 gacacgtatg agaatctgca caagatgctg cgaggtcgcc tgcccgccgt ggtcctagca
     1981 gtggctcagc tcgctggtca gctcctcatc cgactgagcc acgatcacct actgccgctg
     2041 gacttcggcc gctacggaga cgtggtcctc aggcacatcg gcaaccttaa tgagttctct
     2101 ggggacctca aggcgcgcgg gctgaccctg cagtgggtgt actctgcaag gggggactat
     2161 atccgggcgg cggagaagct gcggaaggag atttacagct cggagcagag cgatgagcgt
     2221 ctgatgcgca tgtacaacgt gcgcatcatg agggtggagt tctacttcct gtcccagtac
     2281 gtgtcgccgg ccgactcccc attccgccac attttcctag gccaaggcga ccacactttg
     2341 ggtgccctgg tggaacacct acggatgctg cgctccgatg gctcaggagc tgcctcttct
     2401 gggttgagcc caggtctggg cttccaggag agtcgcttcc ggcgacagct ggcgctgctc
     2461 acgtggacgc tacagggggc agccaacgca ctcagtggcg acgtttggaa catcgacaat
     2521 aacttttgag gccagaagtc ctccatgggc cccacgtgat tctcctttct ccctatttga
     2581 gtggtgcagg caacggaggt gcctgagagc aacctatcct cattaacaac cttggtcctg
     2641 caacgccagt gagacatatt ttctcagtgt gactgttata ccactgttta tccagaaagc
     2701 ggttttcttc ccatcactgg cctctctgcc ttcaggagca tagttcccca tatctagaaa
     2761 ccatctagac actgggatcc agctctctta gcgggtgaga tggatagcgt cattttctta
     2821 tgacacacaa gtggtatgtg ggtggcccaa gggggattag atgtcaataa accatttacc
     2881 tggtaa
//
LOCUS       NM_001437311            5413 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus KIAA1328 homolog (Kiaa1328), transcript variant
            5, mRNA.
ACCESSION   NM_001437311 XM_039097031
VERSION     NM_001437311.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5413)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039097031.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.76445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000018.1  16764868-16765083
            217-359             JAXUCZ010000018.1  16771469-16771611
            360-454             JAXUCZ010000018.1  16776653-16776747
            455-570             JAXUCZ010000018.1  16794966-16795081
            571-698             JAXUCZ010000018.1  16865059-16865186
            699-1372            JAXUCZ010000018.1  16920208-16920881
            1373-1456           JAXUCZ010000018.1  16927043-16927126
            1457-1638           JAXUCZ010000018.1  16983935-16984116
            1639-1747           JAXUCZ010000018.1  16996889-16996997
            1748-5413           JAXUCZ010000018.1  17047419-17051084
FEATURES             Location/Qualifiers
     source          1..5413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5413
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="KIAA1328 homolog"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
     exon            1..216
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    159..161
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="upstream in-frame stop codon"
     exon            217..359
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1952
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="protein hinderin isoform 4"
                     /protein_id="NP_001424240.1"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
                     /translation="MESLKGAGDSVAEQSFCKRGLKSASLKDLCVEDKRRIANLIKEL
                     ARVSEEKEVTEERLKTEQESFEKKIRQLEEQNELIIKEREALQLQYRECQELLSLYQK
                     YLSEQQEKLTMSLSELGAARAQEQQITKKKITHQSSLVNLDGSYLSVAKPQTCQTRAR
                     PKSENQDSASESHTALRNNSLKPVTLHHPKQDLERMSTETRTCTYESPGRRLINAAPV
                     EEALPEELKIKDYPNLLPTPSSQYCGHKYSESEAYVHENYHPTNMASQCCKTHPESCS
                     HCRMSWASLMHDGVTLQPRETDIEKQLSEDRRQQLMLQKMELEIEKERLQQLLAQQET
                     KLLLKQQQLHQSRLDYNWLRTQAVFRSRELVADKDFPKPGSDSGPSLLKPKCDGWLRG
                     TSSSFRKCPDSPNSAQNQKEKKTVEFQSHVENGIQWTCQQNDTCRLQRETATGVRKDA
                     STSPMSTQSPKHPLTPASSSSKHKTSRYETSLLDLVQSLSPNSAPKCQPHSSRAAGTW
                     SALRPTPKTSTWKKVGTHKSPEDLEENQILEDIFFI"
     misc_feature    399..1370
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     misc_feature    399..1370
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     exon            360..454
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            455..570
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            571..698
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1372
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1456
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1638
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1747
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..5413
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcctta gctgtgagtt ctgcaaagat ggcctgtaat cggggagtct cagccaagtc
       61 tggaagcgcc cctctgccat cccttgcagt gaggctgatt gagggtgtga agtgagcctg
      121 tagtggtagg gagaacaagt gtgggtgaac acagttggta gctgggctgg aagtcttttt
      181 ctcttaattt ggaattaccg agtaggagca aatcaggaat ctccacagaa agaaatacaa
      241 gatcaaggct caagttgata aatccaaaag ttgatgctaa agttaaggtt cccaaggtga
      301 ctgatattcc tgcctccatg gagtctttaa aaggtgcagg agattcagta gctgaacaga
      361 gtttctgcaa gagaggactg aagagtgcgt cattgaaaga tttatgtgtt gaggacaaaa
      421 ggcgcattgc caatttaatt aaagaactgg ccagagtaag tgaagaaaag gaggtgacag
      481 aggagcgact gaaaactgag caggagtcct ttgagaagaa gatccggcag ttggaggaac
      541 agaatgaact gatcatcaaa gaaagggaag ctcttcagct acagtataga gaatgtcaag
      601 aacttctaag tctctaccag aagtacctgt cagagcagca agagaagctt accatgtcgc
      661 tctcagagct tggagctgct agagcacagg aacagcagat aaccaagaag aaaatcactc
      721 accagtcttc attggtgaac ctggatggtt cctatctgag tgtagccaaa ccgcaaacct
      781 gccagaccag ggccaggcct aagtcagaaa accaggactc agcttcagaa tcccacacag
      841 cattaaggaa taattctttg aaaccagtaa cacttcatca tcccaaacag gatttagaga
      901 ggatgtcaac agaaaccaga acgtgtactt atgaatctcc agggaggaga ctaataaatg
      961 cagccccagt agaggaagct ctcccagaag agttgaagat aaaggactat ccaaaccttc
     1021 tgcctactcc atctagtcag tactgtggtc ataaatactc tgaaagtgaa gcttatgttc
     1081 atgagaacta tcatcctacg aacatggcct ctcagtgttg taagacacat ccagaatcat
     1141 gcagtcattg taggatgtcc tgggcatctc tcatgcatga tggagtgaca ctgcaaccca
     1201 gagaaaccga catcgaaaaa caactctcag aagatcgaag gcagcagctg atgcttcaga
     1261 aaatggaact ggaaattgaa aaggaacgcc ttcagcaact cctggcccaa caagagacaa
     1321 agcttctcct taaacagcag cagctgcacc aatcccgact agattacaat tggttaagaa
     1381 ctcaagctgt gtttagatct cgagaactgg ttgctgataa agactttcct aaacctggaa
     1441 gtgactctgg accaagttta ttgaagccga aatgtgatgg atggctgcgt ggaacctcat
     1501 cgtccttcag aaagtgccca gactctccaa acagtgcgca aaaccagaag gagaagaaaa
     1561 ctgttgagtt tcagtcacac gtggagaatg gcattcaatg gacatgtcaa cagaatgaca
     1621 catgcagact ccagagagag acagcaactg gagttagaaa agatgcttcc acatctccta
     1681 tgtcaacaca aagccctaaa caccccctga caccagcctc atcgtcatcc aagcacaaaa
     1741 cctcaaggta tgagacatct ctgttggact tggttcagtc tctgagccca aattctgctc
     1801 ctaaatgtca gccccattcc tccagagcag cagggacatg gagtgctctc cgacctaccc
     1861 ctaagacatc tacctggaag aaagtgggga cacataagag ccctgaggac ctggaggaga
     1921 atcagattct ggaagacata tttttcatat gactctgaag cacatgctac agaatttcca
     1981 caggaaatat ttgagtttct ttccatattg atgtaggatg ttaaactgaa aagaagccgt
     2041 gtctctcctt tcgtggagac ctcttgctgg catcctttta tagtattgaa tatagaaagc
     2101 attcttataa atcagggtgg tttttgtcag accagttagc agaaacagac taaagggggt
     2161 cacttagagg taggatcttt tctataccaa acagaaatta gaaattgtgg atactgcctg
     2221 catagtaaaa cccatgaatg tctagtgtca ttttaagagt gttttcaatt tactactgca
     2281 aaaagttgac tctttacaga tggaaaacgt tcccattgac agacccctta aatatgaaag
     2341 tagccacttc agaaaggctc ttctctcctc accaatgcta agtgtggcgc ttcattccga
     2401 cgttgaagtt ggtgactcta atatcatctt acatgggacc aatacttgtg ggtcatagtg
     2461 gtcaaccgag tcattgccac cccttaaacc aaaaggctga atgacttaga gggaagtttg
     2521 caaccagaca gtggcattag accacatgag ggcatggccg cctggggaaa tttaccagtg
     2581 tccaggcagc cacctctcca gtgttccatg atgggtgttt cttgtcgact tcagtgttgt
     2641 aaactttacc tgtggttgtg tctgaggaag atagcactag aggaagagtg gtgtcgagtg
     2701 gctgcaggct ggcaggttcc ttctgcccca cctcacacca taggacgagt atcctcctct
     2761 gagcaccgtg gatgcagagt ctgagaacgc tctgctgatt acccttcttg gcccagatct
     2821 agatcttttc tcctcaggct gagctcagtg ctgttggttc tactcaggct ccctcccaag
     2881 ctcatactct tcctctgaag cagctgcaag ggcaagacta attacccttt ggaaatttaa
     2941 agttcattga aaattccaat tttcttttca aattcagcct gagagtaact agaacagact
     3001 tgttctactt caaaacacct ttaggatatg cctttggagg ggcagaaata gccatattct
     3061 cagttgggtt tccagaaaca tcttttctct atcttgtgtc aaagacagct taactatacc
     3121 tatttcttta cacctgctat aaccatagtc accgttctga gcatcagtag tcttactact
     3181 cctgtatatc tccagaagga aaagaaagag aatctgatct ccttaagaag cttatttaca
     3241 ggtagaagag ttgtaaacgg cctaaaaatg aaagcttttg tgcagtgaca tgccagtgaa
     3301 tagaatttaa ttgcttcttc accagcatgg gaagtttgga agagaaaaaa ggggggtttt
     3361 cagtcagtac actttttata cttcacagat ctgccatgcg ttaccttctt ctcatgcata
     3421 tacatacata catacacaca cacacacaca cacacggata tatatatata tatatatata
     3481 tatatatata tatatatata tatcctagtg actttgttat taaccaaata gtatattgtg
     3541 gcccatccca cagaagaatg ggaagaaagt aggagccatg tgcctccctg gataatgctc
     3601 tcttcggtgg ttggttggga cttgcttggc cagctcctag atgtttcctc caagcaaaac
     3661 tgcactcaat gataaaaatt tagtttaaca agattcacca aggtcaccag atagtaagga
     3721 gcaattcaaa cccagaggtg aagatggggg gaaggggagt cattgttctt ttctttactt
     3781 ctctttccta ttttgagtaa atatcaaaac catcaagacc attttctaca gtccagttat
     3841 tatttatcag acacatggat tggtaaggag aggagagcag tgggaagaag ggattaaagg
     3901 aaacaggcct acatcccttt gcagccttgg tacaattcct tattgcatgc agttctctca
     3961 taaaggagaa gaggaccaga agagagaaat ggagatggtg ggctctggga cccttccact
     4021 gctccttcct cagtgcctta tctgcagtgt ttaatgtttt tcttccaaat ttaagatttc
     4081 taactctcat acttggaaat acaaagaact ccccagggct tacaggtcaa ggggcacagg
     4141 ccctagagag gcacatcagg gctctctgtc tccagcccca tgtccctttg ctgcatcagc
     4201 cgcctccatt accctcttct ttgctcccca ttgcagctca ccactgttag acacatccca
     4261 atggcacact tctcttccca ggtccttctg ggtgaataac ttaagactaa gtttttacca
     4321 ctttgtgaaa ttttccttat gttcctggca ctgtgtactg ttgactccag taagatgtgc
     4381 agatatgtcc aacccataag ccataagctg tgacgtatgg tcaaggatag ctgtgaatgt
     4441 ggcccaacac aaaattgtaa acgtaagaca ttttgagtag tgtggttatt tttgtttttc
     4501 acttttgtgt gtgtgacttg attgtgcagc tctcaaacat gaacattgta tataataaat
     4561 catgtcatca tgttgctgtg tcaaaggctg gccatgcggc aagtccaagc ctctgtggtg
     4621 gccctcctcg tcatgccaca ttgtactggg tactgtttgc ctttcttgtt agagttccag
     4681 gtgtccagac taacatatgc tatgtcggag aagccaagtt caccatttgt aacatacaga
     4741 catgcaggtg agttattgat accttcagat aatgataatt ctacctgcag ttttaggcct
     4801 tatctgctga cctagcccta aaagcctaga ccagagaaaa gctagaatga gaaggtcaaa
     4861 gttcccaaga atgtgaagct gacagttggg gggcactgag acccatctcc ttagaacatg
     4921 gggcaaccaa cagacccaaa ggcagggagc agagtcagtg ttagaacagt acagagctgg
     4981 ttgaccagaa cagtttcatt ccagagctga cacccctctg ccctctgtgg tctgacacct
     5041 gattggctca tgccaagcaa gcactagcac aaacattgcc cacagtgact cccacccaga
     5101 agctccctct ttctcttccc cagatgctgc cccacactct cctccacact ctttccagct
     5161 ctaggtccta aggtggccag gaggctgctg agatgaggga gaccatgctg tatcccaggg
     5221 aaatggggtg agcccttagt tttcaaacct cctctgagag attttaactt gttggattta
     5281 tgtagcattg gaaaatgata aactgtatga attttctgta ttttccatgg acagttattt
     5341 atggaggggc gtttttaact caagtgctag aaatgttaaa tcatcataat aaattcatgc
     5401 tattcagact ttc
//
LOCUS       NM_001437343            4617 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus centrosomal protein 120 (Cep120), transcript
            variant 4, mRNA.
ACCESSION   NM_001437343
VERSION     NM_001437343.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4617)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 4617)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4617)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 4617)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   5  (bases 1 to 4617)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77400.1,
                                           SRR26360181.96477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000018.1  49387941-49388277   c
            338-494             JAXUCZ010000018.1  49383840-49383996   c
            495-609             JAXUCZ010000018.1  49382222-49382336   c
            610-758             JAXUCZ010000018.1  49375066-49375214   c
            759-956             JAXUCZ010000018.1  49373255-49373452   c
            957-1184            JAXUCZ010000018.1  49370600-49370827   c
            1185-1401           JAXUCZ010000018.1  49369293-49369509   c
            1402-1579           JAXUCZ010000018.1  49367897-49368074   c
            1580-1729           JAXUCZ010000018.1  49365316-49365465   c
            1730-1912           JAXUCZ010000018.1  49364545-49364727   c
            1913-2009           JAXUCZ010000018.1  49361228-49361324   c
            2010-2168           JAXUCZ010000018.1  49360986-49361144   c
            2169-2258           JAXUCZ010000018.1  49358919-49359008   c
            2259-2351           JAXUCZ010000018.1  49354506-49354598   c
            2352-2513           JAXUCZ010000018.1  49352257-49352418   c
            2514-2636           JAXUCZ010000018.1  49348629-49348751   c
            2637-2735           JAXUCZ010000018.1  49344147-49344245   c
            2736-2881           JAXUCZ010000018.1  49331773-49331918   c
            2882-4617           JAXUCZ010000018.1  49326266-49328001   c
FEATURES             Location/Qualifiers
     source          1..4617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4617
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
     exon            1..337
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            338..494
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    450..452
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="upstream in-frame stop codon"
     exon            495..609
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            610..758
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            759..956
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..3116
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="isoform 2 is encoded by transcript variant 4;
                     centrosomal protein 120kDa; coiled-coil domain containing
                     100; centrosomal protein of 120 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 2"
                     /protein_id="NP_001424272.1"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
                     /translation="MKLPERQPEFFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIR
                     SSVEVLRVYLALHSKLQIHLCCGDQSLGSTEIPLSGLLKKGSTEINQHPVTVEGAFTL
                     DPPNRAKQKLAPVPVELAPTVGVSVALQREGIGSQSLIELKTQNGHEPEHSQKRVLTP
                     IKEKTLTGPKSPRVSPAPPQNQTPPTKDDATESEVESLQYDKEPKQVVKGTGSIPASL
                     AQPEATGNPSEVVTSGQKIAVPATSHHFCFSIDLRSIHGLEISFPVNCILRYSYPFFG
                     SAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSK
                     DLLLGIARIQLSNILSSEKTRFLGANGEQCWRQTYSEKVPVIAAQGSNNRIVDLSYTM
                     TLEDYGLVKMREIFVSESSQGMSAVGQRASPPPPPPAPCPSEIQVEPRETLEYKAALE
                     LEMWKEMQEDIFESQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYSILEGKLQQ
                     ALTELESREQQLVTAETELQRERKELQLERERNLQELQDSVRRARDDCVHQVELERLK
                     LKQLEEDKHRLQQQLNDAENKYKILEKDFQQFKDQQNNKPEIRLQSEINLLTLEKVEL
                     ERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAE
                     EKDTVKTEQQELLDIRNELNRLRQQEQKQYQDYKEIASGKQGSPRGSGLEEGLDDYLT
                     RLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSASN"
     misc_feature    <774..1166
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <774..1166
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <2103..>3107
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <2103..>3107
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            957..1184
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1401
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1579
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1729
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1912
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2009
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2168
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2258
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2351
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2513
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2636
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2735
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2881
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..4617
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgccct ttgtcctcca acctcccccg ggctctcggc ccgcgggcct ggttgctagg
       61 cggaagcggg gcgcggcggc gtccgctgcg gctgcccggg cgtttgaata gcggcttagc
      121 aggcggcaaa aggtgccggg gcggcgggct tgttggggag cagggccagg cagcggagca
      181 gccttcatcg agtcggggct gggttagggc ctgggcggcg gcctggggag cggggccggc
      241 ctgcgcccct cactcggcct ctttcctgca gaccccgccg ccacgaccat ggtccccaag
      301 tccgaccagc tgctcatcgt cgtatccatc ctcgaaggtc gccatttccc caaacgtcca
      361 aagcatatgc ttgtggtgga agcaaagttt gatggggagc agttggccac tgatcctgtc
      421 gaccatactg accagccaga atttgctact gagttagcct gggagatcga caggaaagtc
      481 cttcatcagc acaggttaca gcgcactccc atcaaactgc agtgctttgc cttggatcct
      541 cagacttctg ccaaggaaac cgtaggctac attgttttgg atttaagaac agctcaagaa
      601 acaaagcagt tcctgctagc ctgttaggag ttgaccctaa ggacatcgtg gcagtgttga
      661 atgaggaggg aggctaccat cagattggac cagcagagtg ttgtactgac tcctttactc
      721 tctcagtgac catagcattt gccacccagt tggaacagtt aattccatgt accatgaagc
      781 ttccagaaag gcagcctgag tttttctttt actattcttt attgggaaat gatgttacaa
      841 atgagccgtt tagtgatttg atcaacccga actttgagcc ggagagggcg tctgtccgca
      901 tacgaagcag cgtggaggtc cttcgtgtgt acctggctct tcactcgaaa ctgcagatcc
      961 atctctgctg tggagaccag tcactcggca gtacagaaat acctctaagt ggattactga
     1021 agaagggcag cacagagatt aaccagcatc cagtcacagt cgagggtgcg tttacccttg
     1081 accctccaaa ccgagccaag cagaagctcg ctcctgttcc tgtcgagctg gccccaactg
     1141 tgggagtgtc agtggctctg cagagagaag gcatcggctc ccagtcttta attgaattaa
     1201 agacccagaa tggacatgag cctgagcact cacagaagag agttttaacc cccataaagg
     1261 agaagacact cactgggcca aaatcaccaa gggtgtcccc tgccccacct caaaaccaga
     1321 cacctccaac caaggacgat gccacagaaa gtgaagtgga gagcctgcag tacgataagg
     1381 agccgaagca ggtggtgaag ggcactggtt ccatacctgc ttcgctggcc cagccagagg
     1441 cgactggcaa cccatcagaa gtggtgacat cggggcagaa gattgctgtt ccagcaacat
     1501 cacaccactt ctgcttttca atagacttga gaagcatcca tggcttggaa attagttttc
     1561 cagtcaactg catattgagg tactcctacc cattcttcgg cagtgcagct cctattatga
     1621 ctaaccctcc tgtagaagtt cggaagaaca tggaagtttt tcttcctcag tcttactgtg
     1681 catttgattt tgcaactatg cctcaccagc tacaagacac cttcctaagg attccactgc
     1741 ttgtagaact atggcacaag gataaaatga gtaaagactt actccttggg attgcaagaa
     1801 ttcagctttc taacatcttg tcttcagaaa agacccggtt tctaggtgct aatggtgaac
     1861 agtgctggcg acagacttac agtgagaaag tgcctgtcat agcggcccag gggtcaaata
     1921 acaggatagt agacctttct tacacaatga ctctggagga ctatggcctg gtgaaaatgc
     1981 gtgagatctt tgtatctgag tcatctcagg gcatgtctgc tgtgggtcag agggcgtctc
     2041 ctcctcctcc tcctccagct ccttgccctt ctgagatcca ggtggagccc cgggagacct
     2101 tagagtacaa ggctgcactg gagctggaga tgtggaaaga gatgcaggag gacatatttg
     2161 aaagtcagct gaagcagaaa gaactggctc acatgcaagc tcttgcagaa gagtggaaaa
     2221 aaagggaccg ggaaagagag tcactagtga agaaaaaggt agctgagtac agtattctag
     2281 aaggcaaact tcaacaagcc ctaacggagc tcgagagccg agagcagcag cttgtcactg
     2341 cagagacaga gcttcaaaga gagagaaagg aactgcagtt agaacgagag cggaaccttc
     2401 aagagctgca ggactctgtc cgaagggcca gagacgactg cgtgcaccaa gtggagctgg
     2461 agaggctgaa gctgaagcag ctggaagagg acaaacaccg ccttcagcag cagcttaatg
     2521 atgctgaaaa taagtataag attttggaaa aagattttca gcagttcaag gaccaacaaa
     2581 acaacaaacc agaaatacgg ctgcagtcag aaataaacct cctcaccttg gaaaaggttg
     2641 aacttgaaag aaagttggag tctgcaacca agtctaaact gcattacaag cagcagtggg
     2701 gccgagcttt gaaagaactt gccagactca agcagaggga gcaagaaagc caaatggctc
     2761 gccttaaaaa acagcaggag gagttggagc agatgcggct gcgttacctg gctgctgagg
     2821 agaaagacac agtgaaaact gagcaacaag aactgctgga cataaggaac gaactgaaca
     2881 ggttacggca gcaagaacag aaacagtacc aggactacaa agagattgca agtgggaaac
     2941 agggcagccc tcggggctct gggctggaag aaggcctgga tgactacttg acacgtctga
     3001 tagaagaacg ggatactttg atgagaacgg gtgtctataa ccatgaggac cgcataataa
     3061 gtgaactcga ccggcagatc agagaggttt tgacaaaaaa cagtgccagt aattaaatgc
     3121 attgaggaag tctttacagc tactctaggt ctgtgttttg aattttttgt aaactcctca
     3181 aaagcaagga aaacggcgac tttagagtgc tctttttaat tttttataag ctgaatttta
     3241 tatattactg tatatagtat ttatttgatt ttacttacgc tacctctcca atgctggttt
     3301 catttgtaat tgtattttat atgctcattt aaaatgactt ttcagtgttc ttcagttcaa
     3361 aatctattgt ttgactttaa aaacagcctt tcagaactta tcccaggaga actggccaca
     3421 gtagttccca gctatataag ttttttatgt tgagtcaaga gagtatgtgt tgcactttaa
     3481 aaatgctgtg ccctgttccc tttgattgta gatatcttca aattaaagcc aattataagt
     3541 gtagccattt ttaaaaaagc atttatatga ccagtctttt tcccttaacc tgtggtattt
     3601 gcacatgaca actttgaaaa taaagcagtc acaggcagaa aagctatgtg acatgttggc
     3661 tgacaaatta gtcattgctt aaatacagtt catgtagatt aagtttaaaa acaaattcgg
     3721 aatttcactg gactccattt taagaatgtg agaaaacagc ttgttctgat cgcagcctcc
     3781 tgctcacagc tgcatgaggc tggttgtcgt taaaattgta ggtcgccttt gtctctcagt
     3841 ggtggcagta cagcttcaga cagactgagg aaacagacac ctagcgacat tagctgagaa
     3901 caccttcctc cctctgcagt cattctgttt tccaagaggc agtgcagcgt gagtcgtgta
     3961 agccgcagag cttccctccg tgttctccag accacctcag cctcatggcg gcactcatcc
     4021 ctatgtctgc acaacaatga acaggttagt gagcaaactc ccagttcatg tgcgatctta
     4081 aaacatagaa agtaaaaatt ctgattcccc aaaataacag atgtaagtgt atccttcggc
     4141 aagtatgagc taattaccag tcacttcagc ataagcaaag cgggttacac ggtaatcttc
     4201 actaggtgtg tttctggttt gtgaaattaa agcctccata ggagtcatat gcttcttttc
     4261 tttaattttc cgtctttgtc ttctaaaagc aactgagcag taaatcacag aaaggctgct
     4321 gggtctgagg gtggtgagac agatgatcat agcagggatt tgaaatatga attatggtta
     4381 cacggtcctg attttcttgg tgacatgaat ggagcaaaag gatttttgtt ttagaaggtc
     4441 ctggcccaat gttggttctt cctcctgtat cctgtgaggc ctggagcttt tcaaacacta
     4501 gagggggcct aagagtaagc agaaggactt ctaaaatgtg tgtgtgcttt gccttcaaga
     4561 aagccatctt tgagctactg taatttgaca aataaaatcc tcactgcgtg catcctt
//
LOCUS       NM_001009258            3188 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus checkpoint with forkhead and ring finger domains
            (Chfr), transcript variant 2, mRNA.
ACCESSION   NM_001009258 XM_213807
VERSION     NM_001009258.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Jung,I., Sohn,D.H., Choi,J., Kim,J.M., Jeon,S., Seol,J.H. and
            Seong,R.H.
  TITLE     SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking
            CHFR mediated ubiquitination and degradation of its major
            components
  JOURNAL   Biochem Biophys Res Commun 418 (3), 512-517 (2012)
   PUBMED   22285184
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Oh,Y.M., Kwon,Y.E., Kim,J.M., Bae,S.J., Lee,B.K., Yoo,S.J.,
            Chung,C.H., Deshaies,R.J. and Seol,J.H.
  TITLE     Chfr is linked to tumour metastasis through the downregulation of
            HDAC1
  JOURNAL   Nat Cell Biol 11 (3), 295-302 (2009)
   PUBMED   19182791
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Yu,X., Minter-Dykhouse,K., Malureanu,L., Zhao,W.M., Zhang,D.,
            Merkle,C.J., Ward,I.M., Saya,H., Fang,G., van Deursen,J. and
            Chen,J.
  TITLE     Chfr is required for tumor suppression and Aurora A regulation
  JOURNAL   Nat Genet 37 (4), 401-406 (2005)
   PUBMED   15793587
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Daniels,M.J., Marson,A. and Venkitaraman,A.R.
  TITLE     PML bodies control the nuclear dynamics and function of the CHFR
            mitotic checkpoint protein
  JOURNAL   Nat Struct Mol Biol 11 (11), 1114-1121 (2004)
   PUBMED   15467728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001009258.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087162.1, SRR26643299.51242.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000012.1  52197661-52197734   c
            75-218              JAXUCZ010000012.1  52197409-52197552   c
            219-318             JAXUCZ010000012.1  52193002-52193101   c
            319-428             JAXUCZ010000012.1  52189107-52189216   c
            429-488             JAXUCZ010000012.1  52188275-52188334   c
            489-704             JAXUCZ010000012.1  52187940-52188155   c
            705-869             JAXUCZ010000012.1  52186341-52186505   c
            870-1029            JAXUCZ010000012.1  52182610-52182769   c
            1030-1184           JAXUCZ010000012.1  52181801-52181955   c
            1185-1347           JAXUCZ010000012.1  52180867-52181029   c
            1348-1493           JAXUCZ010000012.1  52178991-52179136   c
            1494-1610           JAXUCZ010000012.1  52177359-52177475   c
            1611-1694           JAXUCZ010000012.1  52175247-52175330   c
            1695-1765           JAXUCZ010000012.1  52174142-52174212   c
            1766-1853           JAXUCZ010000012.1  52172797-52172884   c
            1854-1961           JAXUCZ010000012.1  52168910-52169017   c
            1962-2034           JAXUCZ010000012.1  52167710-52167782   c
            2035-3188           JAXUCZ010000012.1  52164212-52165365   c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3188
                     /gene="Chfr"
                     /note="checkpoint with forkhead and ring finger domains"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
     exon            1..74
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Chfr"
                     /note="upstream in-frame stop codon"
     exon            75..218
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2077
                     /gene="Chfr"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase CHFR; checkpoint with forkhead
                     and ring finger domains, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHFR isoform 2"
                     /protein_id="NP_001009258.1"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
                     /translation="MEPHGEDEQPPPREPWGRLLRLGAEEDEPQILLWKREWTIGRRR
                     GCDLSFPSNKLVSGDHCKLRVDEKSGEVTLEDTSTNGTVINKLRVVKKQTYPLQSGDI
                     IYLVYRKNEPEHNVAYLYESLNGKQSLTQESLEANKENMFHVTKESSGPGQGDDPQVP
                     LLSPMAQTCLEEPQPSTSTSDLLPTASTSSTEPELTSAGQKHSSSSGPGTISISPKEC
                     SSLVANGELSSLSSVFQDNEASFSLLKTEDTEELEPAKKKMKGDGELDLNLQLSVADQ
                     RGIAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMER
                     SSLCPTCRCPVERICKNHILNNLVEAYLLQHPDKSRSEEDVRSMDARNKITQDMLQPK
                     VRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESEL
                     GATQALGGEAPSTSASLTTAPGYTCPLQGSHAICTCCFQPMPDRRAEHEQDSRIAPQQ
                     CAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLTTR
                     GLTWKNMLTESLLALQRGVFILSDYRITGNTVLCYCCGLRSFRELTYQYRQNIPASEL
                     PVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN"
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    1487..1942
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    1487..1942
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    1976..2047
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     misc_feature    1976..2047
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     exon            219..318
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            319..428
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            429..488
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            489..704
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            705..869
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1029
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1184
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1493
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1610
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1694
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1765
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1853
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1961
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2034
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..3188
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtccccga gatgtctgtt gacagcggtg gcggcgactg tgctgccggt tccgggatcc
       61 gcgcagggag ggggatgtga gtcctatgga gccacacggg gaagacgagc agccgccacc
      121 gcgggagccc tgggggaggc ttcttcgcct aggcgcagag gaggacgaac cccagatcct
      181 tctttggaaa cgcgagtgga ccatcggaag gaggagaggc tgtgacctct cttttcccag
      241 caataaactg gtctctggag atcactgtaa acttagagtg gatgaaaaat ctggtgaggt
      301 gacactggaa gacaccagca ccaatggaac agtaatcaac aaactgcgag ttgttaagaa
      361 gcagacttac cctttacaga gtggggatat catctatttg gtgtacagga agaacgagcc
      421 agagcacaat gtggcatacc tctatgaatc tttaaatggc aaacagagct taactcaaga
      481 atcccttgaa gccaataaag aaaatatgtt ccatgtgacc aaagaatcct caggtccagg
      541 gcagggtgat gacccccagg ttccactctt gtcacccatg gctcagacat gcttagagga
      601 accacagcca tcaacatcga catcagacct ccttcccacg gcctctacct cttctacgga
      661 gccagagctg acctctgcag ggcaaaagca ttcctctagc tctggacctg ggactataag
      721 catctcccca aaagaatgta gttcacttgt tgcaaatggt gaactctcta gcctttcttc
      781 agttttccaa gacaacgaag catccttttc tttgttgaaa accgaagaca ctgaggaatt
      841 ggagcctgcc aaaaaaaaga tgaaaggaga tggggagctt gacttgaacc tccagttatc
      901 agttgcagac cagcgtggaa ttgcccaaac ctcaagtgag gatgtcaaag atgcctctgt
      961 gaaaccagac aagatggagg agacactaac ctgtatcatc tgtcaagacc ttctgcatga
     1021 ctgtgtgagt ttgcagcctt gtatgcacac attttgtgcg gcttgctact ctggttggat
     1081 ggagcgttca tctctgtgcc ctacctgccg atgtccagtg gagcggattt gcaaaaacca
     1141 catcctgaac aaccttgtgg aagcatacct tctccagcac ccagataaga gtcgcagtga
     1201 agaagatgtg agaagtatgg atgcaaggaa taaaatcact caagatatgc tgcaacccaa
     1261 agtcaggagg tctttctctg atgaagaggg gagttcagag gacctgctag agctgtctga
     1321 tgttgatagt gaatcctcag acatcagtca gccatacatt gtatgcagac agtgtcctga
     1381 atacagaagg caagcagtgc agtctcttcc ttgcccagtc ccagagagtg agctgggagc
     1441 cacacaggcc cttggtgggg aagcaccttc aacatctgcc agcttgacaa cagccccggg
     1501 ttatacatgc cctcttcagg gaagccatgc catatgcacc tgctgcttcc agcctatgcc
     1561 ggaccggaga gctgagcatg agcaggattc ccgcatcgcc cctcaacagt gtgcagtgtg
     1621 cctgcagccc ttctgccacc tgtactgggg ctgcacgcga actggctgct ttggctgctt
     1681 ggccccattc tgtgagctca acctggggga caagtgtttg gatggagtgc tgaacaataa
     1741 caattatgag tcggatatcc tgaagaatta cctgacaacc aggggtctga catggaaaaa
     1801 tatgttgaca gagagtctcc tggctctaca gcggggtgta tttatactgt ctgattacag
     1861 aatcactgga aacaccgtgc tgtgttactg ctgtggtctg cgtagcttcc gagagctgac
     1921 ctatcagtat cgtcagaaca ttcctgcttc agagttgcca gtgaccgtaa catcccgtcc
     1981 tgattgctac tggggccgca actgtcgcac tcaggtgaag gctcaccatg caatgaaatt
     2041 caatcacatc tgtgagcaaa caaggttcaa gaactaaata ttggaggaga cacatgaaac
     2101 agttacagag cacaggaggc aatgatacta tggttttttt ttttaaatac catgtacatt
     2161 tttacggttt tccctaagca gcactgaggt ttctggtcag actctctggt gtggcgagct
     2221 ttatcttcag tcacacacac acacacacac acacacactc tacatgcccc actaacctgg
     2281 gaggcctact ggccacactg gccttctagt cagtgtgaga ggatgagcag actgagatcc
     2341 cccctcccac tagacagctc tcccttcctg tgtggtgggg cagtgacagt gcaggtttgc
     2401 aggtttgcag gtttgtactt ctgtgtcttt tctaccttgt accttgacta cagttaaatg
     2461 ggaaagtttg tgggaaaagc tgtcagatat gttagaaaca ttctccggaa ggaaaggaag
     2521 catacgttta cagcctccag ggatgtatag gatattcttc tgtctgaaaa gacacagcct
     2581 tttgtatatt ttttatttta ataagtttgg tggtgcttat cttctaataa gatttaaata
     2641 ttaaaaactg tagcacaaat actataattt ataatttaca aattgactaa aattaggaat
     2701 agcctgacat ttggaagaat gagcatatgt ttttgtttat ttaaaaactt atcaaatgtc
     2761 caaaactgct aatcctgggg aggatgtctt gagtatccag gtccttgaca cagggctggc
     2821 caatgcctct tgtccagcag gccaagccct tagccctcca gtccctgaga gcaactccct
     2881 gctgaagctc cagatggctc cagactgaca gggccttgct tctccagccc tgatctggta
     2941 cattattagg tttgccatgt catctggaat aatacttgaa attttgttct tagttttttt
     3001 taaacttttt atcttttatt gaaatcacct gttatatttg tttgcaaact ggtaactttt
     3061 tgcttctcag gaatacaatt ttcaactgtt gtcttgctct tgatatagac tgagaggcag
     3121 tactctgtgt ttgtgggaga tggttctctt tttttaattc taataaatga gctgtgtttg
     3181 tttctctt
//
LOCUS       NM_001437402            3434 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 6, mRNA.
ACCESSION   NM_001437402 XM_039096702
VERSION     NM_001437402.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096702.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77199.1,
                                           SRR26360181.1741339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000018.1  41067220-41067420   c
            202-297             JAXUCZ010000018.1  41065895-41065990   c
            298-551             JAXUCZ010000018.1  41061600-41061853   c
            552-676             JAXUCZ010000018.1  41061277-41061401   c
            677-967             JAXUCZ010000018.1  41059874-41060164   c
            968-1265            JAXUCZ010000018.1  41049807-41050104   c
            1266-3434           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3434
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..201
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Trim36"
                     /note="upstream in-frame stop codon"
     exon            202..297
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1620
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 6;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 5"
                     /protein_id="NP_001424331.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLR
                     LDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFR
                     PAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDK
                     ADSYVLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSR
                     ELVLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTS
                     LDYIIGDVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSG
                     HDSGSEDAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKG
                     KVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV"
     misc_feature    <286..570
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    <286..570
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    505..651
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    505..651
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    721..912
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    721..912
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    976..1587
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     misc_feature    976..1587
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     exon            298..551
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            552..676
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            677..967
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1265
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..3434
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctaggc ttgtcatttg gcttgcagtg tgatgtgaaa tactccctaa ccctggaggg
       61 tagttatgtt acttaattat gagtaggctt ctggttcagc tattgactgt ggtatttgta
      121 cctcatgaac tttgggttcc ttggatggat aaaatgctag gtcacaatgg aagattttct
      181 gtctctttgt agcattattc tgagaaactt tcaaaagaca ttgatttcct tattggtaag
      241 gaaagccagg tgaagagtca aatttctgaa ctaaacttgt taatgaaaga aacagagtgc
      301 aatggagaga gggcgaagga agaagcgctg gcacattttg agaagctctt tgaaatcctg
      361 gaagacagga agtcgtctgt tctgaaagcc atagatgcct ctaagaaact aagactagat
      421 aaatttcaca ctcaaatgga agagtaccaa ggccttctag agaataacgg gcttgtggga
      481 tatgctcagg aagtgctgaa ggagacggat cagtcttgct ttgtgcagac agcaaagcag
      541 ctccatctca gaatacagaa agctacagaa tccctgaaga gctttagacc tgcagcccag
      601 gcttcttttg aagactatgt tgttaacatt tcgaaacaaa cagaggtgct tggagaattg
      661 tcctttttct ctagtggcat agacattcct gagatcaacg aggaacagag taaagtgtat
      721 aataatgccc tgatagactg gcaccatcca gaaaaggaca aagccgacag ctatgttctc
      781 gaataccgca agattaatag agacgaagaa atgatatcct ggaatgagat agaagttcat
      841 ggcacaagta aagttgtctc caatcttgaa agcaacagtc cctatgcgtt ccgagtgaga
      901 gcttacaggg gttctatctg cagtccctgc agtcgagaac tggttctgca tactcctcca
      961 gctccagttt tcagtttcct gtttgatgaa aagtgtggct acaatactga gcatctcttg
     1021 ctgaacctga agagagaccg ggtagaaagc agagctggat ttaatgtcct cctcgctgcg
     1081 gaacgcatcc aagtgggcca ttacacaagc ttagactaca tcatcgggga tgtcggaatc
     1141 acgaaaggta aacacttctg ggcctgccgt gtggaaccgt attcatacct ggtgaaagtg
     1201 ggagttgctt ccagtgacaa actgcaagag tggctgcgct ctccccggga cgcagctagt
     1261 ccaagatatg agcaagacag tgggcatgac agcggaagtg aggacgccta ttttgattct
     1321 tcacaaccgt ttacattagt tactataggc atgaagaaat tttttatacc caagtcacct
     1381 acttcttcta atgaacccga aaacagagtt ctccccatgc caacaagtat agggattttc
     1441 cttgactgtg ataaaggcaa agtgagcttc tatgatatgg accacatgaa atgcctatat
     1501 gagcgccagg tggactgttc acacacaatg taccccgctt ttgcgttaat gggcagtggc
     1561 gggatccagc ttgaggaaac catcaccgcg aagtatctgg aatatgaaga ggatgtgtag
     1621 cttggacacc ccacaggacg aggatcagaa ctgtgaacaa agccatgccg tggtgttaga
     1681 gtcttcgtaa ctaattacat atcatttacg tctctgtcac cacacctgtt tgtactgtgt
     1741 gattctttgt tttgttttgt tctgctttga cacacacagt ctcagtgtgt agtccaggcc
     1801 agcttcaaac tctgttctgt tatagcctcc ttaggggctg ggattatagg caggcaccac
     1861 catacccagc tagtgtatga ttcacaactt ttttcatgtc ataatggtct taccttttac
     1921 aaatggtggg agtagagact tgtcttaact ggtccaggat agataactct acaatggaag
     1981 tccttctctt tggggacaag gactctaatt gatgtaagtc agctgatggt ggtattattc
     2041 ctgtcccttt gtttgggggt tgcagtggga tacaaagtat ttacaaagtt ctttgtgctt
     2101 gttttcttct ttccttttca ttgtgtatca tgttcatgtc caaagagaag atatttttaa
     2161 atgtttatcg atagaaatta gtactaagcc atgtgtcttg catttgatgt taataggaaa
     2221 ataaatttac agataggtaa aatgatgaag gccataaaat ggtagtatat ttaagtagaa
     2281 aattatgtat tttaaagtgt gtaactactg agtgtatatt gcctggcaaa cgaatactgc
     2341 tttttccctc tatagaccac agactgtatt ggtaagaata tctctaagag tgtctttgct
     2401 gtagtgccca ttgtcctgta catgtagcaa gcatcgtttc atataagaaa cacagggttc
     2461 ttgaacccat gcgactttcc actacaatag aattcttttt caggaaattt tattttcaaa
     2521 ttttcttatt ttagaaaata ctcatttata gcaaagaatt atttttcaga aatactaggg
     2581 aagatggact gatagtgaac acctatcttt ttgtgtcttg tgaactttat gattttggta
     2641 catatgttat acatcagggt tttctggctt ttgtttacag atttgagaag tttgctgtcc
     2701 attttcagcg ttgttgaatg ccagacatgt tacatgttac tactgtccac ttggatggca
     2761 ctgtttgtgg gctcattgtg tggtcataag catttgtagt gtgaatcagt aaaatacaaa
     2821 attccttaga cataatagct aaacatcaca aggatgtgtc tagtcagttt ttacaccttt
     2881 tctacactag atgttaattt ctgcaaggtt actttccaat tatttgaatt gcctttttaa
     2941 aagttaaaat gtccagacac taagacttac atgtgttcag cactgatcat gcaatggaat
     3001 ggtagcattt tggtagaata accaaagctg tttatttgat tgattctttt taatggaagc
     3061 ctgttgggct aatcacactg catctgaccc agcactgact ggtacgcatc cctacgcttg
     3121 tgtagaaata tctggaggat ttgtgtttag tgattgccct tcctctccca cttatatcta
     3181 gcactttatg acataggaaa cagagagaat gtgcagtgtt acctggggtc attgtgcaat
     3241 aatgctgcta aagtcgccgc acgtgtgggt tagtgtgaca ctcaatattc atgtaagcac
     3301 atgtcctgta gacattttaa aatataaagc tttaactgga gtcagagaag cgagctgttc
     3361 gaacactgta tcactgtata gaaattgctt agtggaattc cactttttta aaataaaaaa
     3421 ataaataaag ggaa
//
LOCUS       NM_001437363            1886 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 12, mRNA.
ACCESSION   NM_001437363 XM_063271323
VERSION     NM_001437363.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271323.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2363587.1,
                                           SRR26360181.2363588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-138              JAXUCZ010000012.1  40093232-40093332
            139-308             JAXUCZ010000012.1  40093729-40093898
            309-498             JAXUCZ010000012.1  40096705-40096894
            499-618             JAXUCZ010000012.1  40098953-40099072
            619-800             JAXUCZ010000012.1  40100973-40101154
            801-982             JAXUCZ010000012.1  40102786-40102967
            983-1203            JAXUCZ010000012.1  40106323-40106543
            1204-1278           JAXUCZ010000012.1  40109132-40109206
            1279-1471           JAXUCZ010000012.1  40110908-40111100
            1472-1675           JAXUCZ010000012.1  40112332-40112535
            1676-1886           JAXUCZ010000012.1  40113610-40113820
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1886
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            38..138
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             139..1719
                     /gene="Ccdc63"
                     /note="isoform 3 is encoded by transcript variant 12;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     3"
                     /protein_id="NP_001424292.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEELCPGCSGIPSGPQ"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            139..308
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            309..498
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            499..618
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            619..800
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            801..982
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1203
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1278
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1471
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1675
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1886
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggac attgcagaca gaggagacac
       61 tgagagaacg agaaagaagt gggcttgcta gctttgacct ccaggaccca gtgtctaagc
      121 agaaaggaag cttagacgat gaagaaacac aggaggaagg tctctgaacc ccttccggaa
      181 ctttccgaga aggccaaaga gcagttggct gaggcagagc tacggaaact aaggcagcag
      241 ttccggaaga tggtagacag ccgaaagtct tccaatttcc gcaaccagcg gatgatcgcc
      301 agccagtaca aggagataga gaatttgaaa gcggagcagg cagagaccac cttgcttctg
      361 agcctcgtga agtcgccaaa gaacctagac ctcaaccaga aaaatttcac ggagctgcgc
      421 ttcctgctgc agaccaaggg ggactacgag gctctgatct cctccatgaa ggtgctgctg
      481 ggagaactgg atgacaagat tgttcagatg gagagaaaga tcacaaacca gagacagatc
      541 ttcttgaaga cacaagaggc caacaatccc cggaagctgc agaaacagat ccacattctg
      601 gagaccagac tgaacctggt cactgtccac tttgacacga tgttgacctc caatgcccag
      661 ctccggaagg atattgagga tcttctcttt gagaaggctg cctacgacca tgtctaccag
      721 cagcttcagc ggcgtctgca gacacagaag aagaccatga atgtggccat cgagcagtct
      781 acccaggcct atgagcagag agtggaagcc atggctcgga tggctgccat gaaggaccgc
      841 cagcaaaaag acatctctca gtacaacctg gagatccgag agctcgaacg cctgtatgac
      901 cacgagaaca aactcaagtc ctttctgctt gtcaagctca atgaccgcac ggaattcgag
      961 gaccaggcca agaagcagga agctgtcaaa attaagaagc atgggaaaaa gaggaagggt
     1021 gagagctttg agagctacga ggtggcccat ctccgactgc taaagctggc tgagaacggg
     1081 gacctgaacc agctcactga ggacttcctg gccaaggagg agaagaattt tgctcgcttc
     1141 acctatgtca ccgagctcaa caatgacatg gagaccatgc acaagaggac ccagcggatc
     1201 caggatgaca tcatcaacct gcggtcacag cagcagtcct cccatgaggg cacccggaac
     1261 atcctgaaac agatggagga gaaactgagg aagaccaccg aggacacgga catttatgag
     1321 aacaggtaca gggaaatgag caagaccctg gagtacctca agaactcagt ggagaagctg
     1381 tttaagaaga tcaactgcaa tgccacggag atcctgggga aactgggtga gactgggaag
     1441 atcacggaca gcaaccttca gcagtacttc gctatcatag aaaagaagac aaatgacctc
     1501 ctgcttctgg agtctttccg gcgcctgcag gaggcagagg ggcccgatgt tgatgtccca
     1561 caaccctttg tcaacccctt ctgggggggc tctgccctcc tcaagccccc agagccctta
     1621 agggttgtgc cgcctgtgtt tggggcagac tccttcagtg acaaagttga agaggagctc
     1681 tgtcctgggt gcagtggaat accctctgga ccacagtagc ctccggcagc tggtcttgga
     1741 gaactacctt cagaaggaac gaggaaaaga accacaggag acactgttgg agaaggggga
     1801 cgagataagg gtcaagaaga aggtgataag ctgaaccccg tgggtggctg tattccacac
     1861 cgagaaaata aatgttttct tgccga
//
LOCUS       NM_001437377            4322 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 7, mRNA.
ACCESSION   NM_001437377 XM_006254914
VERSION     NM_001437377.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 4322)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 4322)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 4322)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 4322)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 4322)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 4322)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 4322)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254914.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.467802.1,
                                           SRR26360194.1407939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1487           JAXUCZ010000018.1  70153375-70153674
            1488-1625           JAXUCZ010000018.1  70153761-70153898
            1626-1757           JAXUCZ010000018.1  70154230-70154361
            1758-1819           JAXUCZ010000018.1  70154449-70154510
            1820-4322           JAXUCZ010000018.1  70155741-70158243
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4322
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1859
                     /gene="Mbd1"
                     /note="isoform 7 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 7"
                     /protein_id="NP_001424306.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPP
                     GPVQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPG
                     WVVALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDG
                     EENKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRSKDLKKPGAKMQ"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    <1032..1808
                     /gene="Mbd1"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <1032..1808
                     /gene="Mbd1"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1487
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1625
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1757
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1819
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..4322
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctaaag cggctgctgc
     1201 ccagtattgg gccagggtct gaggaggaag caagattgct tccacatcat acccaccaaa
     1261 agaggtctgc ttctactcga cagctgcaac tgagctctcc cttaaaggct cctttggctg
     1321 tggtcacaac cccaccgggc cctgtccaag attcagggaa gcggcaagca ggtagtggct
     1381 ttgtactgcc ccaacctgac acagaccttg tgtatttaca agagggtacc agcagtctca
     1441 tgcaggtgcc tggccctgct gcagcttcca cagaaaaccc agcacaggag acccagggct
     1501 ctgccccagg ttgggttgtg gccttgcccc aggtgaagca agagaaggcg gatgccccag
     1561 aggagtggac agcagtcaca accttcctga cttcttccac ggtgcagcct ggcttcctta
     1621 gcaaggcgtc aggcctggac cctccacctg tgaaacgaga gccccctggc cctgaggagg
     1681 atggagaaga gaacaaagaa gatgatgtct ctgaatcagc tccagcagaa gagataggag
     1741 ggattggcac cccagtgatc acggagattt tcagcctggg tggaacccgc ctccgggatg
     1801 cagaagcctg gttgccaagg tccaaggacc ttaaaaaacc cggagctaaa atgcagtaga
     1861 ctggaggcct ctgctgactg taggctgaag gtggtatttg cagaccggct ttgtggaaac
     1921 aaccctgatc ctaaaggggc tgggccctgg cccggctgca gagcttgtgt gggaaccaac
     1981 tctaggagga aaacctacaa gcacaaccaa ggagcaggcc tgctcagtcc ttggacctta
     2041 gaggaagcaa gctggagagg aagagaaaga gtagaaggct ggtggaatgt ctgctcctcc
     2101 gtggatctcg atgcagtgag aagttggatg gtagggtagg gaagggtagc tgaagccact
     2161 gcagacagct cacacaagcc acctgcatag cgtccgttgg tggcttctgg atgacctggc
     2221 agtgtgtctg aacattttct cagggaaaca gcagttgcaa tgctatgtga ataaagggag
     2281 aaaggagttg ttgtttgctg agctcctgtg gagccaagcg actctagccc tcacagtagt
     2341 ccttaggaac acactgacgt tacgcacttt tgcaggcagg aaatagattc agaagagacg
     2401 aactttcccg gtgttacaca gctagtgttg ctacattcta gaaacatgcc taggctataa
     2461 aagctttgtt ctttaagcca ctaaattgtt aactgcagtc ttctgtgcaa taatgtacgt
     2521 tacaataaca gtttcagtga ctttgaaaca gcagtggggc actctgagca ctgtaagata
     2581 cccgttccac ttggcctctg tggtctagga gatgcccagg ctgtgggtga acgggtcacc
     2641 ttctcgttag gccctggatg ctgcatccgt tccctttgtt ctgagtgtgc tccccaccgc
     2701 tggcccacag tttgctatgc ccagacgctc tcacttcagg cagagcagtg catggcacta
     2761 aagctgtcag cctgacccct cttttcctga cagcttctct ctgatgacct ctgtgcttgt
     2821 ttcctgcccc cagcccaaac gtttgttaga agactgagtg gatttatgca ctgagtcctg
     2881 cccagagacc agtctcgact cagccgtacc tcattttcca tccttaaatg ccaaaaagtg
     2941 tgaagtttgt tacttagcca gctttacggg cgaggactgg gcacctcgtc atatgtgtgt
     3001 tctgtgcacc ccgtgtgtta gctttgtccc agctctgctg ctttagtaat gcagatatgg
     3061 gtcactctgt ttccagtcca caagacagag gtctgccacc ttgttttctg cctttgccct
     3121 gctttgctag ttgtgtactg gatcattctg ctcttcaacc ctagagctca ccacttgtcc
     3181 ctagtatcct ggtagttcgg acagtggtgt attaacttgt ctttggttgg catttgactt
     3241 gtgaatgaag attctgatta ctatatgtgt ttgactaggg gacaatcaaa agatcagaac
     3301 cactacaaca aaggctgatg tgtgcatgtt aaggatgttt tatgttatgt aatttgcgga
     3361 gatggcttag cctctagggc tgtcatttgt atataatact aggacttaaa gtattcagga
     3421 cggggagtca ggaagggaag gtggaaggac atggaaacct tgaacaagag ttggaattca
     3481 agaagatggc ctggaacccg tgcagtgtct caccgcctcc agcttcaatg atgtttgtat
     3541 cctgcagaag aagctagtgt ccttaggagc atctggccta ggactagaga agctaaagga
     3601 agacccaggg aaattgtagc cgctgaaggc ctggctgtag gacttgctgt ttccccgtac
     3661 caaggtgaga cagcagacta atgacagctt gtatgaactg caacatgctt gctgtccctg
     3721 caccaacctt ccaagtgtta agaacagcct gctgctgctg cttcacttct actagccaca
     3781 gcctttctgt ggatgttctt aactggaatg tatggggaag gatcccagga agcatagtct
     3841 agtcaaggtg acatgttaga aagccacctt accatgactc agctccatga ggtctcacca
     3901 ctcacctgag gataacgtaa caaaactaca ttgctgaaaa ggtaaagctg gagaccatgg
     3961 atttcgtgat ggtcccagca agtaaagaaa tcatgtcccg ctgatccaga acagtcttgc
     4021 tgatctcagc tgtatttgtg ttattcatcc aagtcttgaa agcttagctc actgtacata
     4081 atactgagat tcagaagtgc agttttataa aatgcatcaa tatatattac aagtgataaa
     4141 atagctccgg tttactatgg acttcgatgc tgaaatatag aattgagtat actgtggaga
     4201 agccagtcct tttttgagtt tttttttcaa agtagtatag tagttggaaa caacttaatc
     4261 atttctattt ctaaggtgtt ctattgtaaa gttattttaa aacaaattct cctgttctat
     4321 ta
//
LOCUS       NM_001437374            4487 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 4, mRNA.
ACCESSION   NM_001437374 XM_017600883
VERSION     NM_001437374.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 4487)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 4487)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 4487)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017600883.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.505374.1,
                                           SRR26360176.2435227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1352           JAXUCZ010000018.1  70152879-70153043
            1353-1652           JAXUCZ010000018.1  70153375-70153674
            1653-1790           JAXUCZ010000018.1  70153761-70153898
            1791-1922           JAXUCZ010000018.1  70154230-70154361
            1923-1984           JAXUCZ010000018.1  70154449-70154510
            1985-4487           JAXUCZ010000018.1  70155741-70158243
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4487
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2024
                     /gene="Mbd1"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 4"
                     /protein_id="NP_001424303.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELPYTNQRQNRKCGACAACLRRMDCGHCDFCCDKPKFGGSNQKRQKCRWRQC
                     LQFAMKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPPGPV
                     QDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPGWVV
                     ALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDGEEN
                     KEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRSKDLKKPGAKMQ"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1197..1337
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1197..1337
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1352
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1652
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1790
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1922
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1984
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..4487
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctaccc tatacgaacc
     1201 agcggcagaa ccgcaagtgt ggggcctgtg cagcctgcct acggcggatg gactgtggcc
     1261 actgcgactt ctgctgtgac aagcccaaat tcgggggcag caaccagaag cgccagaagt
     1321 gtcgttggcg ccagtgcctg cagtttgcca tgaagcggct gctgcccagt attgggccag
     1381 ggtctgagga ggaagcaaga ttgcttccac atcataccca ccaaaagagg tctgcttcta
     1441 ctcgacagct gcaactgagc tctcccttaa aggctccttt ggctgtggtc acaaccccac
     1501 cgggccctgt ccaagattca gggaagcggc aagcaggtag tggctttgta ctgccccaac
     1561 ctgacacaga ccttgtgtat ttacaagagg gtaccagcag tctcatgcag gtgcctggcc
     1621 ctgctgcagc ttccacagaa aacccagcac aggagaccca gggctctgcc ccaggttggg
     1681 ttgtggcctt gccccaggtg aagcaagaga aggcggatgc cccagaggag tggacagcag
     1741 tcacaacctt cctgacttct tccacggtgc agcctggctt ccttagcaag gcgtcaggcc
     1801 tggaccctcc acctgtgaaa cgagagcccc ctggccctga ggaggatgga gaagagaaca
     1861 aagaagatga tgtctctgaa tcagctccag cagaagagat aggagggatt ggcaccccag
     1921 tgatcacgga gattttcagc ctgggtggaa cccgcctccg ggatgcagaa gcctggttgc
     1981 caaggtccaa ggaccttaaa aaacccggag ctaaaatgca gtagactgga ggcctctgct
     2041 gactgtaggc tgaaggtggt atttgcagac cggctttgtg gaaacaaccc tgatcctaaa
     2101 ggggctgggc cctggcccgg ctgcagagct tgtgtgggaa ccaactctag gaggaaaacc
     2161 tacaagcaca accaaggagc aggcctgctc agtccttgga ccttagagga agcaagctgg
     2221 agaggaagag aaagagtaga aggctggtgg aatgtctgct cctccgtgga tctcgatgca
     2281 gtgagaagtt ggatggtagg gtagggaagg gtagctgaag ccactgcaga cagctcacac
     2341 aagccacctg catagcgtcc gttggtggct tctggatgac ctggcagtgt gtctgaacat
     2401 tttctcaggg aaacagcagt tgcaatgcta tgtgaataaa gggagaaagg agttgttgtt
     2461 tgctgagctc ctgtggagcc aagcgactct agccctcaca gtagtcctta ggaacacact
     2521 gacgttacgc acttttgcag gcaggaaata gattcagaag agacgaactt tcccggtgtt
     2581 acacagctag tgttgctaca ttctagaaac atgcctaggc tataaaagct ttgttcttta
     2641 agccactaaa ttgttaactg cagtcttctg tgcaataatg tacgttacaa taacagtttc
     2701 agtgactttg aaacagcagt ggggcactct gagcactgta agatacccgt tccacttggc
     2761 ctctgtggtc taggagatgc ccaggctgtg ggtgaacggg tcaccttctc gttaggccct
     2821 ggatgctgca tccgttccct ttgttctgag tgtgctcccc accgctggcc cacagtttgc
     2881 tatgcccaga cgctctcact tcaggcagag cagtgcatgg cactaaagct gtcagcctga
     2941 cccctctttt cctgacagct tctctctgat gacctctgtg cttgtttcct gcccccagcc
     3001 caaacgtttg ttagaagact gagtggattt atgcactgag tcctgcccag agaccagtct
     3061 cgactcagcc gtacctcatt ttccatcctt aaatgccaaa aagtgtgaag tttgttactt
     3121 agccagcttt acgggcgagg actgggcacc tcgtcatatg tgtgttctgt gcaccccgtg
     3181 tgttagcttt gtcccagctc tgctgcttta gtaatgcaga tatgggtcac tctgtttcca
     3241 gtccacaaga cagaggtctg ccaccttgtt ttctgccttt gccctgcttt gctagttgtg
     3301 tactggatca ttctgctctt caaccctaga gctcaccact tgtccctagt atcctggtag
     3361 ttcggacagt ggtgtattaa cttgtctttg gttggcattt gacttgtgaa tgaagattct
     3421 gattactata tgtgtttgac taggggacaa tcaaaagatc agaaccacta caacaaaggc
     3481 tgatgtgtgc atgttaagga tgttttatgt tatgtaattt gcggagatgg cttagcctct
     3541 agggctgtca tttgtatata atactaggac ttaaagtatt caggacgggg agtcaggaag
     3601 ggaaggtgga aggacatgga aaccttgaac aagagttgga attcaagaag atggcctgga
     3661 acccgtgcag tgtctcaccg cctccagctt caatgatgtt tgtatcctgc agaagaagct
     3721 agtgtcctta ggagcatctg gcctaggact agagaagcta aaggaagacc cagggaaatt
     3781 gtagccgctg aaggcctggc tgtaggactt gctgtttccc cgtaccaagg tgagacagca
     3841 gactaatgac agcttgtatg aactgcaaca tgcttgctgt ccctgcacca accttccaag
     3901 tgttaagaac agcctgctgc tgctgcttca cttctactag ccacagcctt tctgtggatg
     3961 ttcttaactg gaatgtatgg ggaaggatcc caggaagcat agtctagtca aggtgacatg
     4021 ttagaaagcc accttaccat gactcagctc catgaggtct caccactcac ctgaggataa
     4081 cgtaacaaaa ctacattgct gaaaaggtaa agctggagac catggatttc gtgatggtcc
     4141 cagcaagtaa agaaatcatg tcccgctgat ccagaacagt cttgctgatc tcagctgtat
     4201 ttgtgttatt catccaagtc ttgaaagctt agctcactgt acataatact gagattcaga
     4261 agtgcagttt tataaaatgc atcaatatat attacaagtg ataaaatagc tccggtttac
     4321 tatggacttc gatgctgaaa tatagaattg agtatactgt ggagaagcca gtcctttttt
     4381 gagttttttt ttcaaagtag tatagtagtt ggaaacaact taatcatttc tatttctaag
     4441 gtgttctatt gtaaagttat tttaaaacaa attctcctgt tctatta
//
LOCUS       NM_001004204            3851 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 6, mRNA.
ACCESSION   NM_001004204 XM_213763
VERSION     NM_001004204.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001004204.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000012.1  32093062-32093268   c
            208-272             JAXUCZ010000012.1  32090917-32090981   c
            273-442             JAXUCZ010000012.1  32090465-32090634   c
            443-537             JAXUCZ010000012.1  32090152-32090246   c
            538-715             JAXUCZ010000012.1  32079959-32080136   c
            716-1001            JAXUCZ010000012.1  32077686-32077971   c
            1002-1152           JAXUCZ010000012.1  32072686-32072836   c
            1153-1336           JAXUCZ010000012.1  32071923-32072106   c
            1337-1480           JAXUCZ010000012.1  32070118-32070261   c
            1481-3851           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3851
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..207
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            208..272
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            273..442
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            443..537
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    527..529
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            538..715
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..1501
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001004204.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    584..1327
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    584..1327
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    617..679
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    788..874
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1091..1153
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1364..1426
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            716..1001
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1152
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1336
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1480
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..3851
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatgatca cccactgccg gtgtggacac atcacatgct gtggttctca gtgatcacat
       61 aacgtgagcc tgtgtggaca cgtcacactg ctgttatttc ccgcacccat cttttttgtc
      121 aggcaccaaa gacttccttc cctctctaca cctggctgct acatgactaa ggaattacta
      181 gagcactttt ggtggggggt cttctagagc gctaggatta aaggcatgca aggcggaaga
      241 taccaggatc tccaaggaaa ttgcagataa agctccacag gtgtccatgg tgacctcacg
      301 cagctttctg gcagttctga ttggggaatc gtaccaacct gcctgtttat aagaaggacc
      361 tgacacagga caccacccag agagggaatc agggtgcgac ggacagacaa agcatttgaa
      421 tttggagcgt aaagaacctc caccacatct gtgaaggaaa ctcatgtcta agagcacccc
      481 gacctttgac actctaagga caggtggatg tgatctttac cacagatgac cctttcggtt
      541 gccgctggtg agaagcatgt tcagcattaa ccccttggag aacctgaagc tgtacatcag
      601 cagccggcca ccgttggtgg tttttatgat cagtgtcagc gccatggcca tcgccttcct
      661 caccctgggc tacttcttca agatcaagga gattaagtcc ccagaaatgg ctgaggattg
      721 gaatactttc ctgctccggt ttaatgattt ggacttgtgt gtatcagaaa atgagacact
      781 gaagcatctc tccaacgata ccaccacacc tgagagcacc atgaccatcg ggcaaaccag
      841 atcgtccacc cagccgcccc agtccctgga ggagtcaggc cccatcaata tttcagtggc
      901 cattaccttg accttggacc ctctcaagcc ctttggaggg tactctcgaa atgtcacaca
      961 cctgtactcc accatccttg gccatcagat tggattgtca ggcagggaag cccatgagga
     1021 gatcaacatc accttcaccc tgcctgctgc ctggaatgcc gatgactgtg ctctccatgg
     1081 ccactgtgag caggtggtgt tcacagcatg catgaccctc acagctgccc ctggagtctt
     1141 ccctgtcacc gttcagccac ctcactgtgt ccccgacaca tacagcaacg ccacactctg
     1201 gtacaagatc ttcacaactg ccagagatgc caacacgaaa tacgctcaag actacaaccc
     1261 tttctggtgt tacaagggcg ccattgggaa agtctaccac gctttaaatc ccaagctcac
     1321 cgtcattgtc ccagatgacg accgctcctt aataaacctg catctcatgc acaccagtta
     1381 cttccttttc gtgatggtga taacgatgtt ctgctatgca gttatcaaag gcagacccag
     1441 caaactgcgg cagagcaatc ctgaattttg ccctgagaag gtggctttgg ctgatgccta
     1501 atcccacagc tccccatttt ctgagagacc aagaaccatg atcattgcct gctgaatcgg
     1561 ccagggcctg gccactctgt gaatacacga tcttgcaatg ttgggttatt ccagccaaag
     1621 acatttcaag tgcctgtaac tgatctgtac atatttataa acgttgatct ggaaactggt
     1681 cctgtggtgc acgtgctttg ccctggatgc ggccggaacc cgtcagcctc actgaggggc
     1741 aggagggcac tgacatgggg ttcttccatg aagtgccggg ggatgtggga atcttgccag
     1801 agctgagcgt gtcgtgttcc aacaccagcg gccgaggttg gctgcggttc ttgtctcaga
     1861 cgggggtgtg cagtgttgga cgctgtgtgc acctttgtca ggacactgtt tcagaagcca
     1921 ccattccctc ctgcggctct cacgtgtctc agtgaccata tagcgacagc agtagttcct
     1981 tctcagtttg cttgcaagga aactgttttt aaaagagaaa acaagctaca ttttatattc
     2041 cccttgttag gacagacagg cttgtctatc caggtcaaag gtcacgcccc caaggcattt
     2101 ctgtagtgaa gagcagagtt ccgtctccac actggcccct aggaactgga gtgctttgct
     2161 cctctgtgct cctggtagag aagttcctgg cttgagaagt ggcggtgtaa tggggacaca
     2221 gggcagcaca ggctgcctaa cttcacaagg cagaagagat ggcgggctgc tgtaatgctc
     2281 acaagcaggg cttgcttttt ttttctttct aaaattcgtt tcgcattcat ttttgtacat
     2341 cacacatcta tctccagaag gagaatgaac attataggta tataatgtgg agctggtgca
     2401 gggaagatct gaaggaagaa ggcgtatgag gcgctgatgg ctggccagtc aaaaccagaa
     2461 gcgttttcct taggacagtt gtgaccatcc ggccccagtg ccctctcgca tttcctttag
     2521 gaaagtcatt cgcattccct tctgcgagtt acttgtattt gcagtggttt tctatcaatg
     2581 ccttgcctta atgcccatgc agtgttcttc caggcagtgt tccagacttg ctgggtgtga
     2641 ggatgaatgc atgttaggag cagccctctg gaggccgagg gaggagaatc tcgagtgcga
     2701 ggctggcctg ggccacatac tgatagcctg tctcacagga agaaaaacta cttaggtatg
     2761 tcagcacttc tgtcccgtaa ctgtaggtct gtctcagttg cagttaactt gctgtatccc
     2821 gaaccttact ggcctagaga attttatccc aggcattctt agatggaaaa caatactttg
     2881 gatttttgtt ctaaattgaa gcttgtgaaa ataatcactg tagttaggtg acgccctaat
     2941 gttttttaaa gcagaggtga gttacttata agatggctaa tgtgtgaatt tcatttagtc
     3001 ttcccttaga ctttgagagc cttgtcaggc aggatggaga aaacccacgt ggcttagctg
     3061 gtatgaatgt gtcatcagga ccatcaagtt tcagattaag tagtaagacc cagtagagta
     3121 agacatgaga agaaatcacc ttcattggtc tgtcggctgt gttcctctta gtcatccttg
     3181 tgttaatgac aggcagtggc tgggatttgt agagggtggg aaggaggaac accataagac
     3241 ctggggagag gaagtcccca aaatgcttga gagtgaccca tcctgaggcc agatacatat
     3301 tttaaagccc aagtattcgc catagcaggt agacagatgg aggatggctg gggaaggagg
     3361 ttgtgggctg agtttagggg actgcagaca catctgggcc tggtcctcag ctgctccttg
     3421 gtggtaaacc tcaaaaatgg catgtcagat tggccactag agacctctga ccccagcagc
     3481 actggcttgt cctcaggtgt gggtgtgtca gaagtcagtg acttcctggg aaatggttgt
     3541 ttcggatcac attgatcttt ccttttgtct ttcaccgtat ggtaggactt gaatcagttt
     3601 tgattctgtg tgtacgttct cttcgtttgg aacctggcgt ttctgtctgt tcttggcagt
     3661 gcataggaac ccagcctcct gtattttgac cctcctgcag gcactgtggg acccaagggt
     3721 agcagatcca tctcccgtcc cttgctgcat gatggtcact agctgatctg tgatggcatc
     3781 cctccctcat tgattttctg tgtttgaagt atgtgcacat gtgctttaca gaataaaaca
     3841 tctggattta c
//
LOCUS       NM_001437414            3213 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 6, mRNA.
ACCESSION   NM_001437414 XM_063285680
VERSION     NM_001437414.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3213)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3213)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063285680.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.2896.1,
                                           SRR26360172.409910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               JAXUCZ010000001.1  165852282-165852716
            436-610             JAXUCZ010000001.1  165857557-165857731
            611-752             JAXUCZ010000001.1  165859584-165859725
            753-882             JAXUCZ010000001.1  165862701-165862830
            883-1061            JAXUCZ010000001.1  165864598-165864776
            1062-1147           JAXUCZ010000001.1  165866964-165867049
            1148-1320           JAXUCZ010000001.1  165867251-165867423
            1321-1396           JAXUCZ010000001.1  165869240-165869315
            1397-1527           JAXUCZ010000001.1  165870275-165870405
            1528-3213           JAXUCZ010000001.1  165870906-165872591
FEATURES             Location/Qualifiers
     source          1..3213
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3213
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..435
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..610
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..752
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    735..737
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             747..1763
                     /gene="Xndc1"
                     /note="isoform 3 is encoded by transcript variant 6; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 3"
                     /protein_id="NP_001424343.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MSIDVGRSSWPLDRPFVTLLPATMLMSLTDSKEGKNRSGVRMFK
                     DDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDPVKDPSSPGSSG
                     LNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQLQPGPLGRAARM
                     VLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRGKRRKVQEQRRP
                     LSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSIEALPRHAATCG
                     ESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICELQFSAREIEEHASVCGE
                     VFPA"
     misc_feature    <753..989
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    <753..989
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            753..882
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1061
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1147
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1320
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1396
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1527
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..3213
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgacc cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata
       61 tatattaaaa actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct
      121 gtacttcctc agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg
      181 ttttgggcta cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa
      241 taagatctga gcaccgaaac tgaagctact acgacatgaa gtttatggac gcgggtgaga
      301 agggttggga tttgtcctct ggagaggaat agctgaaagg gaagagggtg gccaacaaga
      361 aaatgaacag agcacccggt ttcggggtct taatcctcag agagactgag agctgaagaa
      421 ccaaatggga cctcagagta atgtaaggac tcttcttctt ccaaaagcta ccaagagcaa
      481 aacatagacc gtgtcaccgt ggttacagaa gacatcctgg gaggaagcat atctgcctcg
      541 caaataaaga agctggtggc ctccgatggc tcctgtgaag atcagccatg tggtgtcatt
      601 ttcctctcag gatcccaaat atcctgtgga gaacttgctg aacccagaca gtcataaggg
      661 accttggctc agctgccctc gggacaagac tgggcaactg aaagtggagt ttcagctgga
      721 gagagcagtg cccataagct acatcgatgt cgattgacgt gggtcgttct tcttggcccc
      781 tggacagacc ttttgtcacc ctgctccctg caaccatgct catgtccctc actgactcaa
      841 aggaggggaa gaaccgctca ggggtccgga tgtttaaaga tgatgatttt ctgattccag
      901 cctcaggaga atcatgggat cgacttcgat tgacctgctc ccaacctttc acacgtcatc
      961 aatcctttgg cctggccttc ctccgagtac gttcctctct ggactctctg tctgaccctg
     1021 taaaggatcc ctcatcccct gggagctctg ggcttaatca gaactcttct gataagctgg
     1081 agtctgatcc tagcccctgg ctgactaatc cttctatccg gaggaccttc ttcccagatc
     1141 cccagacgag caccaaggaa atttcagcgc tcaagggtat gttgaagcag ttgcagccag
     1201 ggcctctggg gcgggcagcc cgcatggtgc tttctgctgc ccataaggca cctccagcca
     1261 gtgtcgtaag cccaaacaat agccatggag aaccagattc cagtcatccc gagcgtgcag
     1321 agcccagagc agaagaacca aacaggaaga acaatgcaag cagagggaag aggaggaaag
     1381 tccaggagca aaggagaccg ttgtccagct caagctctca gccaaatagg agggcaacag
     1441 gaaggacaaa gcaaagacag caacgacctc aggccaaaag tgatggcagt ggtgtgcagg
     1501 ctactggaca gtgtcccatt tgtacaggtt ccttcagtat tgaggctctt ccccggcatg
     1561 ctgccacttg tggagagagc tccccacccc agccagcttc tcctacctcc ttgtcttcct
     1621 cagagtctgt gctgtgggtg tcttccccag agagctcgcc gccaccatct tcctgggtcc
     1681 aatgccctat ttgtgaatta cagttctcgg caagagaaat agaagaacat gccagcgtgt
     1741 gtggggaagt ttttccagcc tgagcagtga cattctgcta accctttctt gatgttggag
     1801 cctggggaat ggatctcttg tggctaagaa gcattggtcc cctcccttct gtgattacct
     1861 caggactctg cctgcctgag gacactttgg acccagcttg ctccccattc ccgttgccaa
     1921 ggctgtgtca ctatggtacc caattctcat aaggatattt tccccttaga acatatttgg
     1981 tagaattgat gatctctcca aggccttaga acactatcta gaatgtgatt tccaatgccc
     2041 atttccctga aaggaaaacg gaggctcacc tagggggaaa tactgcctga aaattataaa
     2101 gtcctatgat ggtctgggaa gatgagtgag tcttgagcat gacactgaca ctgagtccca
     2161 tctgaccttg accttctata tctttcatgg gtgtctgccc caggtgtaat cagatactgc
     2221 cctgaaactt cacactactt accataggtg tggaatggac gttcagtgac acaaaaaccc
     2281 ctcacagggt tcttaaagga accagagaga tttccttcta aggaataggc gtggctgtaa
     2341 aagtttgagc aaatctcgtt ctaactattt gagatagttg gaccatagtg tctccccaag
     2401 gtcccctgga gctgcgatgg tccaattctg ctttgaagaa ttatgcacgc ttcccttttc
     2461 cccaggagat gtcttcatgt ggcactaaca cccgtccccc ttatccccaa ggtacagggc
     2521 agggagagag cagctggtcc tggtgaaggg agggcttggg gtggggcctt gagtgggaat
     2581 gaaagagcat gtgagccgca gtcaagggag aggcagagca ggagttcaag ccttcagccc
     2641 ctgcccacag aagtgggtgc agccatggat cccctttcgg taagagaccc ttgcttccct
     2701 cccctcctca tcccagtccc cagggggatg cagggacagc ctgctgctgt tggtgggaga
     2761 gcccctggat tcctgatcca gggcctagaa gaaaagagca gggagctgga cctggtagaa
     2821 caggacgcaa cagtaccaag gaggggagat gctctccaag gtagaaggca gagtgagagt
     2881 atccggtgga gggaaagcac cttaaggtcc tactagagtc tttcatagag aaagggttta
     2941 gggaaagtgc agcttaaaga ccctctgtgt gggcatgtct gaacttgtcc ttcagagaga
     3001 tgagcagcta caagatggga actggattcc tgtcggatgt gtataggtta ggtgcctagt
     3061 gcggccccaa ccacctactt taatcacctc tcttcaggga actaacttgg gccctgttat
     3121 gtctgatttt tataagaatg gaagtgggct gagtaaatac tccccatact agcttttcct
     3181 acatgagtct acataataaa atggtgaaca aga
//
LOCUS       NM_001025665            2097 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 1, mRNA.
ACCESSION   NM_001025665 XM_222186
VERSION     NM_001025665.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001025665.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000012.1  40085187-40085357
            172-272             JAXUCZ010000012.1  40093232-40093332
            273-509             JAXUCZ010000012.1  40093662-40093898
            510-699             JAXUCZ010000012.1  40096705-40096894
            700-819             JAXUCZ010000012.1  40098953-40099072
            820-1001            JAXUCZ010000012.1  40100973-40101154
            1002-1183           JAXUCZ010000012.1  40102786-40102967
            1184-1404           JAXUCZ010000012.1  40106323-40106543
            1405-1479           JAXUCZ010000012.1  40109132-40109206
            1480-1672           JAXUCZ010000012.1  40110908-40111100
            1673-1876           JAXUCZ010000012.1  40112332-40112535
            1877-2097           JAXUCZ010000012.1  40113600-40113820
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2097
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..171
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            172..272
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    250..252
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     exon            273..509
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2019
                     /gene="Ccdc63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_001020836.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR"
     misc_feature    <775..1596
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <775..1596
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            510..699
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            700..819
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1001
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1183
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1404
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1479
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1672
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1876
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2097
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttttgtt ttctctggtt gacgtgtggg ccatgatcct ccacatagtt ccaagaaggc
       61 tgccatagct ccagacatca aagcctcgta caagcagaat cccaacagga aaggaagatg
      121 gaccagttgc tgatttccat ggactcaacc gtatcacagc cgctgcaaat ggacattgca
      181 gacagaggag acactgagag aacgagaaag aagtgggctt gctagctttg acctccagga
      241 cccagtgtct aagcagaaag gaagcttaga cgattgaagc aacaaagaaa gaaggcctct
      301 ttaggtcacc tgggcatcct ctttctctgt cttgcccaga tgaagaaaca caggaggaag
      361 gtctctgaac cccttccgga actttccgag aaggccaaag agcagttggc tgaggcagag
      421 ctacggaaac taaggcagca gttccggaag atggtagaca gccgaaagtc ttccaatttc
      481 cgcaaccagc ggatgatcgc cagccagtac aaggagatag agaatttgaa agcggagcag
      541 gcagagacca ccttgcttct gagcctcgtg aagtcgccaa agaacctaga cctcaaccag
      601 aaaaatttca cggagctgcg cttcctgctg cagaccaagg gggactacga ggctctgatc
      661 tcctccatga aggtgctgct gggagaactg gatgacaaga ttgttcagat ggagagaaag
      721 atcacaaacc agagacagat cttcttgaag acacaagagg ccaacaatcc ccggaagctg
      781 cagaaacaga tccacattct ggagaccaga ctgaacctgg tcactgtcca ctttgacacg
      841 atgttgacct ccaatgccca gctccggaag gatattgagg atcttctctt tgagaaggct
      901 gcctacgacc atgtctacca gcagcttcag cggcgtctgc agacacagaa gaagaccatg
      961 aatgtggcca tcgagcagtc tacccaggcc tatgagcaga gagtggaagc catggctcgg
     1021 atggctgcca tgaaggaccg ccagcaaaaa gacatctctc agtacaacct ggagatccga
     1081 gagctcgaac gcctgtatga ccacgagaac aaactcaagt cctttctgct tgtcaagctc
     1141 aatgaccgca cggaattcga ggaccaggcc aagaagcagg aagctgtcaa aattaagaag
     1201 catgggaaaa agaggaaggg tgagagcttt gagagctacg aggtggccca tctccgactg
     1261 ctaaagctgg ctgagaacgg ggacctgaac cagctcactg aggacttcct ggccaaggag
     1321 gagaagaatt ttgctcgctt cacctatgtc accgagctca acaatgacat ggagaccatg
     1381 cacaagagga cccagcggat ccaggatgac atcatcaacc tgcggtcaca gcagcagtcc
     1441 tcccatgagg gcacccggaa catcctgaaa cagatggagg agaaactgag gaagaccacc
     1501 gaggacacgg acatttatga gaacaggtac agggaaatga gcaagaccct ggagtacctc
     1561 aagaactcag tggagaagct gtttaagaag atcaactgca atgccacgga gatcctgggg
     1621 aaactgggtg agactgggaa gatcacggac agcaaccttc agcagtactt cgctatcata
     1681 gaaaagaaga caaatgacct cctgcttctg gagtctttcc ggcgcctgca ggaggcagag
     1741 gggcccgatg ttgatgtccc acaacccttt gtcaacccct tctggggggg ctctgccctc
     1801 ctcaagcccc cagagccctt aagggttgtg ccgcctgtgt ttggggcaga ctccttcagt
     1861 gacaaagttg aagaggttcc tcacagagct ctgtcctggg tgcagtggaa taccctctgg
     1921 accacagtag cctccggcag ctggtcttgg agaactacct tcagaaggaa cgaggaaaag
     1981 aaccacagga gacactgttg gagaaggggg acgagataag ggtcaagaag aaggtgataa
     2041 gctgaacccc gtgggtggct gtattccaca ccgagaaaat aaatgttttc ttgccga
//
LOCUS       NM_001437378             867 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 2, mRNA.
ACCESSION   NM_001437378 XM_039094840
VERSION     NM_001437378.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039094840.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.104598.1,
                                           SRR26360181.2560874.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680446,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000016.1  82528885-82529051   c
            168-248             JAXUCZ010000016.1  82512490-82512570   c
            249-367             JAXUCZ010000016.1  82511368-82511486   c
            368-528             JAXUCZ010000016.1  82508838-82508998   c
            529-867             JAXUCZ010000016.1  82504646-82504984   c
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..867
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..167
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             78..596
                     /gene="Cfap97d2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 2"
                     /protein_id="NP_001424307.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKMEEERLSIIDRNNYLLLQRVASAMKTGRRIDGQNNFTWRRKSREQ
                     ALMKVQKQNQAVPERLRSSEPWYGAQRWREDWTAMATRPCTCRHTWRKGADREAQQGH
                     SLIWMRSLKRKG"
     misc_feature    159..434
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    159..434
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            168..248
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..367
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..528
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..867
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcaaac agctctgcgg gggctgtact gctgtgcctg ctcttccctg aagggaccct
       61 ggagtttgtg atctgagatg catagagtgc cccagctgac caccccgtgg gctagtagag
      121 acctgcagag agcctgggag aaaacctacc agaaccacag gaaaaaggtc cagaacgccc
      181 aaccactcgt ggacacccgc ccaccacaga cttacagcca cctccaccta aagttcaaga
      241 agttgaagat ggaggaagag agactctcca tcattgacag aaacaactac ctgcttctgc
      301 agagggtggc ctccgccatg aaaaccggga gacggattga tgggcaaaat aacttcacat
      361 ggagaaggaa atcgagagaa caggcattga tgaaagtgca gaaacaaaat caagccgttc
      421 cagaaagact cagaagctca gagccctggt atggagcaca gagatggcgg gaggactgga
      481 ctgccatggc cacgcgtccc tgcacatgca gacacacctg gagaaaagga gctgatcgtg
      541 aagcccaaca aggccacagc ctcatctgga tgcgcagcct gaagcggaag gggtgagggt
      601 tcacgaccca accaccgaaa gaagaccagg gcctggaagc tccgatgagg ccttcctgtg
      661 tctcccaggg gtgggggtgg ggatgtgggg tgtgcaggtc tagcatccga gatcacgctg
      721 gctctgggga cggctgtggg agctgtgacg cggcactctg aagcttcacg gtcacggccg
      781 tcgccagatg acacagcacg gctgtttact gtgtttcttg gaccgataac caaaaacaaa
      841 atatgcagag tgactctgcg agttaca
//
LOCUS       NM_001437372            2814 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437372 XM_006254910
VERSION     NM_001437372.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2814)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 2814)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 2814)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 2814)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 2814)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 2814)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 2814)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 2814)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 2814)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 2814)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254910.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1893458.1,
                                           SRR26360172.788548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1352           JAXUCZ010000018.1  70152879-70153043
            1353-1652           JAXUCZ010000018.1  70153375-70153674
            1653-1790           JAXUCZ010000018.1  70153761-70153898
            1791-1922           JAXUCZ010000018.1  70154230-70154361
            1923-1984           JAXUCZ010000018.1  70154449-70154510
            1985-2814           JAXUCZ010000018.1  70158915-70159744
FEATURES             Location/Qualifiers
     source          1..2814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2814
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2057
                     /gene="Mbd1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 2"
                     /protein_id="NP_001424301.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELPYTNQRQNRKCGACAACLRRMDCGHCDFCCDKPKFGGSNQKRQKCRWRQC
                     LQFAMKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPPGPV
                     QDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPGWVV
                     ALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDGEEN
                     KEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNENEYFTEL
                     QLKEEIL"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1197..1337
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1197..1337
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1352
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1652
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1790
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1922
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1984
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2814
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctaccc tatacgaacc
     1201 agcggcagaa ccgcaagtgt ggggcctgtg cagcctgcct acggcggatg gactgtggcc
     1261 actgcgactt ctgctgtgac aagcccaaat tcgggggcag caaccagaag cgccagaagt
     1321 gtcgttggcg ccagtgcctg cagtttgcca tgaagcggct gctgcccagt attgggccag
     1381 ggtctgagga ggaagcaaga ttgcttccac atcataccca ccaaaagagg tctgcttcta
     1441 ctcgacagct gcaactgagc tctcccttaa aggctccttt ggctgtggtc acaaccccac
     1501 cgggccctgt ccaagattca gggaagcggc aagcaggtag tggctttgta ctgccccaac
     1561 ctgacacaga ccttgtgtat ttacaagagg gtaccagcag tctcatgcag gtgcctggcc
     1621 ctgctgcagc ttccacagaa aacccagcac aggagaccca gggctctgcc ccaggttggg
     1681 ttgtggcctt gccccaggtg aagcaagaga aggcggatgc cccagaggag tggacagcag
     1741 tcacaacctt cctgacttct tccacggtgc agcctggctt ccttagcaag gcgtcaggcc
     1801 tggaccctcc acctgtgaaa cgagagcccc ctggccctga ggaggatgga gaagagaaca
     1861 aagaagatga tgtctctgaa tcagctccag cagaagagat aggagggatt ggcaccccag
     1921 tgatcacgga gattttcagc ctgggtggaa cccgcctccg ggatgcagaa gcctggttgc
     1981 caaggctaca taaactgtta gcagtaaatg aaaatgagta ttttactgag ctgcagttga
     2041 aagaagaaat attgtaggag agaaaagcaa ttattattaa gagaagaaag acattctttt
     2101 gtggctgaaa agctgaacct ggaattcagg aaatggaatc taaatctaga gatgtaccat
     2161 gtagaaaatc tgaagtgggt gggttacaaa taattaagca cactaatttg aagaaaacca
     2221 tccttaaaca tgtgtacaca tggattgcac ttagtatctg tcagtgactg gccttattac
     2281 tgtcctcccc cttcctcttc ttgttccccc atccctctta acaggggcac cacagtagca
     2341 gtcagtttgc tcttaagcag tgtaactccg ttttatggtt actaggagct acaactctgg
     2401 tttccatgta tgctgaagac cgtctagttt cctggactgc attgccagtt ttgcctggga
     2461 tcccgattct caagaattga gtatctgaac ttctgatccg aagctcattc ctccagtcag
     2521 acaactgccc tgctagtatt tctgatctgc cctcttcctg tgttagccca aagtgtgggc
     2581 cccattttct gttcagtgca gtaggaagat tttgttcaca gatcttactg gttgtgtagc
     2641 tcgacaaggc actttggctt cctgagcctt agttgacttc actgcaaact aaagccaata
     2701 ccctcagttc cttcaaccct gtaagaattt tgtcaacctc aaaggttgtt tctggaaata
     2761 ctttgcaaat tgtaaaaaaa aaaaaaaaaa aaaaaaaaag agagagaaac aata
//
LOCUS       NM_001437222            2788 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            7, mRNA.
ACCESSION   NM_001437222
VERSION     NM_001437222.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2788)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2788)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2788)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2788)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2788)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.34966.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000012.1  24760247-24760313   c
            68-314              JAXUCZ010000012.1  24759745-24759991   c
            315-492             JAXUCZ010000012.1  24759477-24759654   c
            493-633             JAXUCZ010000012.1  24756632-24756772   c
            634-745             JAXUCZ010000012.1  24756440-24756551   c
            746-868             JAXUCZ010000012.1  24756223-24756345   c
            869-985             JAXUCZ010000012.1  24754191-24754307   c
            986-1125            JAXUCZ010000012.1  24753946-24754085   c
            1126-1289           JAXUCZ010000012.1  24752946-24753109   c
            1290-1409           JAXUCZ010000012.1  24751630-24751749   c
            1410-1492           JAXUCZ010000012.1  24749484-24749566   c
            1493-1556           JAXUCZ010000012.1  24749332-24749395   c
            1557-1624           JAXUCZ010000012.1  24749165-24749232   c
            1625-1701           JAXUCZ010000012.1  24749003-24749079   c
            1702-1786           JAXUCZ010000012.1  24748839-24748923   c
            1787-2014           JAXUCZ010000012.1  24748522-24748749   c
            2015-2155           JAXUCZ010000012.1  24748072-24748212   c
            2156-2788           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2788
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..67
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2431
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424151.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    101..112
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    107..166
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    278..340
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    449..>610
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    449..>610
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    650..1222
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    650..1222
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    737..739
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(926..928,968..979,983..985,995..1006,1013..1015,
                     1019..1027)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(926..928,968..979,983..985,995..1006,1013..1015,
                     1019..1027)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(998..1000,1016..1018)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(998..1000,1016..1018)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1013..1015,1022..1024)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1013..1015,1022..1024)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1025..1027,1031..1033,1043..1048)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1025..1027,1031..1033,1043..1048)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1034..1036
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1244..1945
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1244..1945
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1265..1267,1271..1273,1280..1282,1286..1291,
                     1295..1297,1427..1429,1433..1435,1484..1486,1493..1519)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1265..1267,1271..1273,1280..1282,1286..1291,
                     1295..1297,1427..1429,1433..1435,1484..1486,1493..1519)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1637..1639
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2024..2398
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2024..2398
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            68..314
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..492
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..633
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..745
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..868
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..985
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1125
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1289
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1409
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1492
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1556
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1624
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1701
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1786
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2014
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2155
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2788
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactacttg cagggttcag gagggggcac aagcatggaa caacgttggg gtctacttcg
       61 gaaagtgcaa cagtggtccc caagaccctc tcagaccatc tacagacgtg tggaaggccc
      121 tcaactggag aacctagagg aggaagatag ggaggaaggg gaggagcttc ctgcccagtt
      181 ctgccccatg gaactcaaag gccctgagcg cttaggctcc tgtcctggga ggtccattcc
      241 cataccctgg gctgcagcag gtcgaaaggc tgctccctat ctggtcctga ccaccctgct
      301 aatcttcact ggggccttcc tcctgggcta cgtggccttt cgagggtcct gccaggcatg
      361 tggggactct gtgttggtgg ttggtgaaga tgtcaactct gaggactcca gccggggcac
      421 gttgtactgg agtgacctcc aggacatgtt tctccggttc cttggggagg gacgcatgga
      481 ggacaccatc aggctgacca gcctccggga acgcgtggcc ggctcagcca gaatggccac
      541 cctggtccaa gacatcctcg ataagctctc gcgccagaag ctggaccacg tgtggactga
      601 cacgcactat gtgggacttc agttcccgga cccggctcac cctaacaccc tgcactgggt
      661 gggtgcagac gggagcgtcc aagagcagct accgctggag gatccggaag tctactgtcc
      721 ctacagcgcc acgggcaacg ccacgggcaa gcttgtgtac gcccactacg ggcggcggga
      781 ggacctgcag gacctgaaag ccaaggacgt ggagctggcc ggcagcctcc tgctagtgcg
      841 tgctgggatt acaagcttcg cccagaaggt agccattgcc caggactttg gggcccacgg
      901 agtgctgata taccctgacc cagcggactt ctcccaagac ccccacaagc caggcctgtc
      961 tagtgacagg gctgtgtatg gacatgtgca cctgggaact ggggaccctt acacgcctgg
     1021 cttcccgtcc ttcaatcaaa cccagttccc tccagtagaa tcatcggggc ttcccaacat
     1081 ccctgcccag cccatcagtg ccgacgttgc tgatcgcttg ctcaggaaac tcacaggtcc
     1141 cgtggctcct caggaatgga agggtcgcct ctcagactct ccgtatcgcc tgggacctgg
     1201 gccaggctta cgccttgtgg tcaacaacca cagaacctct actcccatca gtaacatctt
     1261 tgcgtgcatc gagggcttcg cagagccaga tcactatgtc gttatcgggg cccagaggga
     1321 tgcctggggc ccaggagcag ccaagtctgc agtggggact gccatcctcc tggagctggt
     1381 tcggaccttt tcctccatgg tcagcagtgg ctttagacct cgaagaagtc ttttgttcat
     1441 cagctgggac ggaggtgact ttggcagcgt gggagccacg gagtggttgg agggctacct
     1501 cagcgtgcta cacctcaaag ctgtcgtgta tgtgagcctg gacaactccg tgttgggaga
     1561 cggcaaattc catgctaaga ccagccccct tctcgtcagc ctcattgaga atatcctgaa
     1621 gcaggtggat tcccctaacc acagtggaca gacactctac gatcaagtgg cattcaccca
     1681 cccaagctgg gatgctgaag tgatccagcc cctgcccatg gacagcagcg catattcctt
     1741 cacagctttt gcgggcgtcc cagctgtgga gttctccttc atggaggacg atagggtgta
     1801 cccattcctg cacacgaagg aggacacgta tgagaatctg cacaagatgc tgcgaggtcg
     1861 cctgcccgcc gtggtcctag cagtggctca gctcgctggt cagctcctca tccgactgag
     1921 ccacgatcac ctactgccgc tggacttcgg ccgctacgga gacgtggtcc tcaggcacat
     1981 cggcaacctt aatgagttct ctggggacct caaggcgcgc gggctgaccc tgcagtgggt
     2041 gtactctgca aggggggact atatccgggc ggcggagaag ctgcggaagg agatttacag
     2101 ctcggagcag agcgatgagc gtctgatgcg catgtacaac gtgcgcatca tgagggtgga
     2161 gttctacttc ctgtcccagt acgtgtcgcc ggccgactcc ccattccgcc acattttcct
     2221 aggccaaggc gaccacactt tgggtgccct ggtggaacac ctacggatgc tgcgctccga
     2281 tggctcagga gctgcctctt ctgggttgag cccaggtctg ggcttccagg agagtcgctt
     2341 ccggcgacag ctggcgctgc tcacgtggac gctacagggg gcagccaacg cactcagtgg
     2401 cgacgtttgg aacatcgaca ataacttttg aggccagaag tcctccatgg gccccacgtg
     2461 attctccttt ctccctattt gagtggtgca ggcaacggag gtgcctgaga gcaacctatc
     2521 ctcattaaca accttggtcc tgcaacgcca gtgagacata ttttctcagt gtgactgtta
     2581 taccactgtt tatccagaaa gcggttttct tcccatcact ggcctctctg ccttcaggag
     2641 catagttccc catatctaga aaccatctag acactgggat ccagctctct tagcgggtga
     2701 gatggatagc gtcattttct tatgacacac aagtggtatg tgggtggccc aagggggatt
     2761 agatgtcaat aaaccattta cctggtaa
//
LOCUS       NM_001437306             723 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 186 member A
            (Fam186a), transcript variant 2, mRNA.
ACCESSION   NM_001437306
VERSION     NM_001437306.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2108385.1,
                                           SRR26360181.63576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000007.1  132936016-132936283 c
            269-417             JAXUCZ010000007.1  132934481-132934629 c
            418-597             JAXUCZ010000007.1  132933001-132933180 c
            598-723             JAXUCZ010000007.1  132922410-132922535 c
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..723
                     /gene="Fam186a"
                     /note="family with sequence similarity 186 member A"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
     exon            1..268
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    236..238
                     /gene="Fam186a"
                     /note="upstream in-frame stop codon"
     exon            269..417
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..619
                     /gene="Fam186a"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Protein FAM186A-like"
                     /codon_start=1
                     /product="family with sequence similarity 186 member A
                     isoform 2"
                     /protein_id="NP_001424235.1"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
                     /translation="MPSISSFKKIPKFTKLQRPVLDLLIDDSKRSDVFKRRGQAPVEA
                     VWNADLSTSSYPVVEKTPMNLLWAQLGGYPDIPKLLQLDIQSTLRKSLASICPRSKKI
                     RK"
     exon            418..597
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            598..723
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttcggg tagggtggag ttgttcgggc aaaatgctgc tgctgggttc cactggggaa
       61 acttctcccg tgaggatgct tctgagctcc accagtgtct tccgggaagt ccttccgctg
      121 aggcaggctg ggaagttggc actgagggag atccgagggg tctttgggag cgcagctggc
      181 actgctgggc gagtatgtgt ggggccagcg acagcgccgg aagtctaacg gtcactgagg
      241 ccacgcacag tctcaagtct tcttactgct tgagagggtg tttaaactaa atcttagcca
      301 gcccatgccc tccatctcca gctttaagaa gatacccaaa ttcaccaaac ttcaacggcc
      361 ggtcttggac ttattgattg atgacagcaa aagatccgat gttttcaaaa gacgtgggca
      421 agccccagtg gaggctgtgt ggaatgctga cctgtctaca tcaagctacc cagtggtaga
      481 gaaaacacca atgaatctac tctgggccca gctgggcggg tacccagata ttcccaaact
      541 gctgcagtta gatattcagt cgaccttaag aaaatctctt gcctccatct gcccacggtc
      601 taagaagatt cgaaagtgaa cacaaaacta aaagacaagc acgtagaaat caaatttcaa
      661 tgtttcagta aaacgttggt ttttggcttt ttgtcttaca taaaatatta attattatgt
      721 tta
//
LOCUS       NM_001437219            2858 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            4, mRNA.
ACCESSION   NM_001437219
VERSION     NM_001437219.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2858)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2858)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2858)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.34954.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000012.1  24761280-24761362   c
            84-137              JAXUCZ010000012.1  24760247-24760300   c
            138-384             JAXUCZ010000012.1  24759745-24759991   c
            385-562             JAXUCZ010000012.1  24759477-24759654   c
            563-703             JAXUCZ010000012.1  24756632-24756772   c
            704-815             JAXUCZ010000012.1  24756440-24756551   c
            816-938             JAXUCZ010000012.1  24756223-24756345   c
            939-1055            JAXUCZ010000012.1  24754191-24754307   c
            1056-1195           JAXUCZ010000012.1  24753946-24754085   c
            1196-1359           JAXUCZ010000012.1  24752946-24753109   c
            1360-1479           JAXUCZ010000012.1  24751630-24751749   c
            1480-1562           JAXUCZ010000012.1  24749484-24749566   c
            1563-1626           JAXUCZ010000012.1  24749332-24749395   c
            1627-1694           JAXUCZ010000012.1  24749165-24749232   c
            1695-1771           JAXUCZ010000012.1  24749003-24749079   c
            1772-1856           JAXUCZ010000012.1  24748839-24748923   c
            1857-2084           JAXUCZ010000012.1  24748522-24748749   c
            2085-2225           JAXUCZ010000012.1  24748072-24748212   c
            2226-2858           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2858
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..83
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..137
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2501
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424148.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    171..182
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    177..236
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    348..410
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    519..>680
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    519..>680
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    720..1292
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    720..1292
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    807..809
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(996..998,1038..1049,1053..1055,1065..1076,
                     1083..1085,1089..1097)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(996..998,1038..1049,1053..1055,1065..1076,
                     1083..1085,1089..1097)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1068..1070,1086..1088)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1068..1070,1086..1088)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1083..1085,1092..1094)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1083..1085,1092..1094)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1095..1097,1101..1103,1113..1118)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1095..1097,1101..1103,1113..1118)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1104..1106
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1314..2015
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1314..2015
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1335..1337,1341..1343,1350..1352,1356..1361,
                     1365..1367,1497..1499,1503..1505,1554..1556,1563..1589)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1335..1337,1341..1343,1350..1352,1356..1361,
                     1365..1367,1497..1499,1503..1505,1554..1556,1563..1589)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1707..1709
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2094..2468
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2094..2468
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            138..384
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..562
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..703
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..815
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..938
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1055
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1195
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1359
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1479
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1562
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1626
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1694
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1771
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1856
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2084
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2225
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2858
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acaggcacga ggcagggact gggggttcag gagggggcac aagcatggaa caacgttggg
      121 gtctacttcg gaaagtgcaa cagtggtccc caagaccctc tcagaccatc tacagacgtg
      181 tggaaggccc tcaactggag aacctagagg aggaagatag ggaggaaggg gaggagcttc
      241 ctgcccagtt ctgccccatg gaactcaaag gccctgagcg cttaggctcc tgtcctggga
      301 ggtccattcc cataccctgg gctgcagcag gtcgaaaggc tgctccctat ctggtcctga
      361 ccaccctgct aatcttcact ggggccttcc tcctgggcta cgtggccttt cgagggtcct
      421 gccaggcatg tggggactct gtgttggtgg ttggtgaaga tgtcaactct gaggactcca
      481 gccggggcac gttgtactgg agtgacctcc aggacatgtt tctccggttc cttggggagg
      541 gacgcatgga ggacaccatc aggctgacca gcctccggga acgcgtggcc ggctcagcca
      601 gaatggccac cctggtccaa gacatcctcg ataagctctc gcgccagaag ctggaccacg
      661 tgtggactga cacgcactat gtgggacttc agttcccgga cccggctcac cctaacaccc
      721 tgcactgggt gggtgcagac gggagcgtcc aagagcagct accgctggag gatccggaag
      781 tctactgtcc ctacagcgcc acgggcaacg ccacgggcaa gcttgtgtac gcccactacg
      841 ggcggcggga ggacctgcag gacctgaaag ccaaggacgt ggagctggcc ggcagcctcc
      901 tgctagtgcg tgctgggatt acaagcttcg cccagaaggt agccattgcc caggactttg
      961 gggcccacgg agtgctgata taccctgacc cagcggactt ctcccaagac ccccacaagc
     1021 caggcctgtc tagtgacagg gctgtgtatg gacatgtgca cctgggaact ggggaccctt
     1081 acacgcctgg cttcccgtcc ttcaatcaaa cccagttccc tccagtagaa tcatcggggc
     1141 ttcccaacat ccctgcccag cccatcagtg ccgacgttgc tgatcgcttg ctcaggaaac
     1201 tcacaggtcc cgtggctcct caggaatgga agggtcgcct ctcagactct ccgtatcgcc
     1261 tgggacctgg gccaggctta cgccttgtgg tcaacaacca cagaacctct actcccatca
     1321 gtaacatctt tgcgtgcatc gagggcttcg cagagccaga tcactatgtc gttatcgggg
     1381 cccagaggga tgcctggggc ccaggagcag ccaagtctgc agtggggact gccatcctcc
     1441 tggagctggt tcggaccttt tcctccatgg tcagcagtgg ctttagacct cgaagaagtc
     1501 ttttgttcat cagctgggac ggaggtgact ttggcagcgt gggagccacg gagtggttgg
     1561 agggctacct cagcgtgcta cacctcaaag ctgtcgtgta tgtgagcctg gacaactccg
     1621 tgttgggaga cggcaaattc catgctaaga ccagccccct tctcgtcagc ctcattgaga
     1681 atatcctgaa gcaggtggat tcccctaacc acagtggaca gacactctac gatcaagtgg
     1741 cattcaccca cccaagctgg gatgctgaag tgatccagcc cctgcccatg gacagcagcg
     1801 catattcctt cacagctttt gcgggcgtcc cagctgtgga gttctccttc atggaggacg
     1861 atagggtgta cccattcctg cacacgaagg aggacacgta tgagaatctg cacaagatgc
     1921 tgcgaggtcg cctgcccgcc gtggtcctag cagtggctca gctcgctggt cagctcctca
     1981 tccgactgag ccacgatcac ctactgccgc tggacttcgg ccgctacgga gacgtggtcc
     2041 tcaggcacat cggcaacctt aatgagttct ctggggacct caaggcgcgc gggctgaccc
     2101 tgcagtgggt gtactctgca aggggggact atatccgggc ggcggagaag ctgcggaagg
     2161 agatttacag ctcggagcag agcgatgagc gtctgatgcg catgtacaac gtgcgcatca
     2221 tgagggtgga gttctacttc ctgtcccagt acgtgtcgcc ggccgactcc ccattccgcc
     2281 acattttcct aggccaaggc gaccacactt tgggtgccct ggtggaacac ctacggatgc
     2341 tgcgctccga tggctcagga gctgcctctt ctgggttgag cccaggtctg ggcttccagg
     2401 agagtcgctt ccggcgacag ctggcgctgc tcacgtggac gctacagggg gcagccaacg
     2461 cactcagtgg cgacgtttgg aacatcgaca ataacttttg aggccagaag tcctccatgg
     2521 gccccacgtg attctccttt ctccctattt gagtggtgca ggcaacggag gtgcctgaga
     2581 gcaacctatc ctcattaaca accttggtcc tgcaacgcca gtgagacata ttttctcagt
     2641 gtgactgtta taccactgtt tatccagaaa gcggttttct tcccatcact ggcctctctg
     2701 ccttcaggag catagttccc catatctaga aaccatctag acactgggat ccagctctct
     2761 tagcgggtga gatggatagc gtcattttct tatgacacac aagtggtatg tgggtggccc
     2821 aagggggatt agatgtcaat aaaccattta cctggtaa
//
LOCUS       NM_001437400            4127 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 4, mRNA.
ACCESSION   NM_001437400 XM_039096700
VERSION     NM_001437400.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4127)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4127)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4127)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4127)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096700.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77206.1,
                                           SRR26360181.2995621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000018.1  41088223-41088526   c
            305-539             JAXUCZ010000018.1  41084042-41084276   c
            540-865             JAXUCZ010000018.1  41075830-41076155   c
            866-1012            JAXUCZ010000018.1  41073397-41073543   c
            1013-1108           JAXUCZ010000018.1  41065895-41065990   c
            1109-1362           JAXUCZ010000018.1  41061600-41061853   c
            1363-1487           JAXUCZ010000018.1  41061277-41061401   c
            1488-1778           JAXUCZ010000018.1  41059874-41060164   c
            1779-1958           JAXUCZ010000018.1  41049925-41050104   c
            1959-4127           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4127
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..304
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2032
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 4 is encoded by transcript variant 4;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 4"
                     /protein_id="NP_001424329.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MEGDASDSQVTIKNIEKELICPACKELFTHPLILPCQHSVCHKC
                     VKELLLSLDDSFNDVASDSSNQSSPRLRLTSPSMDKIDKINRPGWKRNSLTPRPTMFP
                     CPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCM
                     DCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRP
                     VCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKET
                     ECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENN
                     GLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQT
                     EVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKADSYVLEYRKINRDEEMI
                     SWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELVLHTPPAPVFSFLFDE
                     KCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGITKDMSKTV
                     GMTAEVRTPILILHNRLH"
     misc_feature    323..616
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    323..616
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    692..856
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    692..856
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    869..1003
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    869..1003
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    1007..1381
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1007..1381
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1316..1462
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1316..1462
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1532..1723
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1532..1723
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1787..>1957
                     /gene="Trim36"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     misc_feature    1787..>1957
                     /gene="Trim36"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     exon            305..539
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..865
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1012
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1108
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1362
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1487
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1778
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1958
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..4127
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtccgcg cgagccgccg ccgcagccgg cagcggggcg tcattcgccg ctccctgggc
       61 cctcgcaggg agcaaccgca ctctccgcgc ccgtgctttc gcctgcgccg gccagtccct
      121 cgccgcgtgg cccgctggcc ggatctggcg gaccagcttg ccctccggtc tgacccgagg
      181 ctcccgaatc gccgcgggga ctcgcccaca cgaccctgct ggggcccgct gcgcctgtaa
      241 agactcggtg gttgatgtca cccggcggag ggctgcgatg gagggggatg cttcagactc
      301 tcaggtgact atcaagaata tcgaaaagga gcttatttgc ccagcatgca aggagctgtt
      361 tacacacccg ctgatccttc cctgccagca cagcgtctgt cataaatgtg tgaaagaact
      421 cttactgtct cttgatgact cattcaacga tgtggcgtca gacagctcta atcagagcag
      481 ccctcggctc cggctcacct cccccagcat ggataaaatc gacaagatta acagaccagg
      541 ctggaagcgt aattcactga cccccagacc aaccatgttt ccttgtcctg gctgcgagca
      601 tgatgtggat cttggagagc gaggagtcag tggtctgttt cgaaatttca ctttggaaac
      661 gattgtcgag aggtaccggc aggctgctag ggcagccaca gccattatgt gtgacctttg
      721 taaaccacca ccccaggaat ctacaaagag ctgcatggat tgtagtgcaa gctactgcaa
      781 cgaatgcttc aaaatttatc atccctgggg cacggtaaaa gcccagcatg agtatgtggg
      841 ccccaccact aatttcagac ccaagatttt aatgtgccca gaacatgaga cagagagaat
      901 aaacatgtac tgtgaactgt gcaggagacc ggtttgccac ctctgtaagt tgggtgggaa
      961 tcattccaat caccgggtaa ccaccatgag cagtgcctac aaaacattaa aggagaaact
     1021 ttcaaaagac attgatttcc ttattggtaa ggaaagccag gtgaagagtc aaatttctga
     1081 actaaacttg ttaatgaaag aaacagagtg caatggagag agggcgaagg aagaagcgct
     1141 ggcacatttt gagaagctct ttgaaatcct ggaagacagg aagtcgtctg ttctgaaagc
     1201 catagatgcc tctaagaaac taagactaga taaatttcac actcaaatgg aagagtacca
     1261 aggccttcta gagaataacg ggcttgtggg atatgctcag gaagtgctga aggagacgga
     1321 tcagtcttgc tttgtgcaga cagcaaagca gctccatctc agaatacaga aagctacaga
     1381 atccctgaag agctttagac ctgcagccca ggcttctttt gaagactatg ttgttaacat
     1441 ttcgaaacaa acagaggtgc ttggagaatt gtcctttttc tctagtggca tagacattcc
     1501 tgagatcaac gaggaacaga gtaaagtgta taataatgcc ctgatagact ggcaccatcc
     1561 agaaaaggac aaagccgaca gctatgttct cgaataccgc aagattaata gagacgaaga
     1621 aatgatatcc tggaatgaga tagaagttca tggcacaagt aaagttgtct ccaatcttga
     1681 aagcaacagt ccctatgcgt tccgagtgag agcttacagg ggttctatct gcagtccctg
     1741 cagtcgagaa ctggttctgc atactcctcc agctccagtt ttcagtttcc tgtttgatga
     1801 aaagtgtggc tacaatactg agcatctctt gctgaacctg aagagagacc gggtagaaag
     1861 cagagctgga tttaatgtcc tcctcgctgc ggaacgcatc caagtgggcc attacacaag
     1921 cttagactac atcatcgggg atgtcggaat cacgaaagat atgagcaaga cagtgggcat
     1981 gacagcggaa gtgaggacgc ctattttgat tcttcacaac cgtttacatt agttactata
     2041 ggcatgaaga aattttttat acccaagtca cctacttctt ctaatgaacc cgaaaacaga
     2101 gttctcccca tgccaacaag tatagggatt ttccttgact gtgataaagg caaagtgagc
     2161 ttctatgata tggaccacat gaaatgccta tatgagcgcc aggtggactg ttcacacaca
     2221 atgtaccccg cttttgcgtt aatgggcagt ggcgggatcc agcttgagga aaccatcacc
     2281 gcgaagtatc tggaatatga agaggatgtg tagcttggac accccacagg acgaggatca
     2341 gaactgtgaa caaagccatg ccgtggtgtt agagtcttcg taactaatta catatcattt
     2401 acgtctctgt caccacacct gtttgtactg tgtgattctt tgttttgttt tgttctgctt
     2461 tgacacacac agtctcagtg tgtagtccag gccagcttca aactctgttc tgttatagcc
     2521 tccttagggg ctgggattat aggcaggcac caccataccc agctagtgta tgattcacaa
     2581 cttttttcat gtcataatgg tcttaccttt tacaaatggt gggagtagag acttgtctta
     2641 actggtccag gatagataac tctacaatgg aagtccttct ctttggggac aaggactcta
     2701 attgatgtaa gtcagctgat ggtggtatta ttcctgtccc tttgtttggg ggttgcagtg
     2761 ggatacaaag tatttacaaa gttctttgtg cttgttttct tctttccttt tcattgtgta
     2821 tcatgttcat gtccaaagag aagatatttt taaatgttta tcgatagaaa ttagtactaa
     2881 gccatgtgtc ttgcatttga tgttaatagg aaaataaatt tacagatagg taaaatgatg
     2941 aaggccataa aatggtagta tatttaagta gaaaattatg tattttaaag tgtgtaacta
     3001 ctgagtgtat attgcctggc aaacgaatac tgctttttcc ctctatagac cacagactgt
     3061 attggtaaga atatctctaa gagtgtcttt gctgtagtgc ccattgtcct gtacatgtag
     3121 caagcatcgt ttcatataag aaacacaggg ttcttgaacc catgcgactt tccactacaa
     3181 tagaattctt tttcaggaaa ttttattttc aaattttctt attttagaaa atactcattt
     3241 atagcaaaga attatttttc agaaatacta gggaagatgg actgatagtg aacacctatc
     3301 tttttgtgtc ttgtgaactt tatgattttg gtacatatgt tatacatcag ggttttctgg
     3361 cttttgttta cagatttgag aagtttgctg tccattttca gcgttgttga atgccagaca
     3421 tgttacatgt tactactgtc cacttggatg gcactgtttg tgggctcatt gtgtggtcat
     3481 aagcatttgt agtgtgaatc agtaaaatac aaaattcctt agacataata gctaaacatc
     3541 acaaggatgt gtctagtcag tttttacacc ttttctacac tagatgttaa tttctgcaag
     3601 gttactttcc aattatttga attgcctttt taaaagttaa aatgtccaga cactaagact
     3661 tacatgtgtt cagcactgat catgcaatgg aatggtagca ttttggtaga ataaccaaag
     3721 ctgtttattt gattgattct ttttaatgga agcctgttgg gctaatcaca ctgcatctga
     3781 cccagcactg actggtacgc atccctacgc ttgtgtagaa atatctggag gatttgtgtt
     3841 tagtgattgc ccttcctctc ccacttatat ctagcacttt atgacatagg aaacagagag
     3901 aatgtgcagt gttacctggg gtcattgtgc aataatgctg ctaaagtcgc cgcacgtgtg
     3961 ggttagtgtg acactcaata ttcatgtaag cacatgtcct gtagacattt taaaatataa
     4021 agctttaact ggagtcagag aagcgagctg ttcgaacact gtatcactgt atagaaattg
     4081 cttagtggaa ttccactttt ttaaaataaa aaaataaata aagggaa
//
LOCUS       NM_001437412            3083 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 4, mRNA.
ACCESSION   NM_001437412 XM_006229906
VERSION     NM_001437412.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229906.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.785394.1,
                                           SRR26360194.334944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               JAXUCZ010000001.1  165852282-165852716
            436-610             JAXUCZ010000001.1  165857557-165857731
            611-752             JAXUCZ010000001.1  165859584-165859725
            753-931             JAXUCZ010000001.1  165864598-165864776
            932-1017            JAXUCZ010000001.1  165866964-165867049
            1018-1190           JAXUCZ010000001.1  165867251-165867423
            1191-1266           JAXUCZ010000001.1  165869240-165869315
            1267-1397           JAXUCZ010000001.1  165870275-165870405
            1398-3083           JAXUCZ010000001.1  165870906-165872591
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3083
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..435
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..610
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    545..547
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             566..1633
                     /gene="Xndc1"
                     /note="isoform 2 is encoded by transcript variant 4; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 2"
                     /protein_id="NP_001424341.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQ
                     LKVEFQLERAVPISYIDVDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSL
                     DSLSDPVKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALK
                     GMLKQLQPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRK
                     NNASRGKRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPIC
                     TGSFSIEALPRHAATCGESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICE
                     LQFSAREIEEHASVCGEVFPA"
     misc_feature    566..859
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    566..859
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            611..752
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..931
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1017
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1190
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1266
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1397
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..3083
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgacc cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata
       61 tatattaaaa actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct
      121 gtacttcctc agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg
      181 ttttgggcta cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa
      241 taagatctga gcaccgaaac tgaagctact acgacatgaa gtttatggac gcgggtgaga
      301 agggttggga tttgtcctct ggagaggaat agctgaaagg gaagagggtg gccaacaaga
      361 aaatgaacag agcacccggt ttcggggtct taatcctcag agagactgag agctgaagaa
      421 ccaaatggga cctcagagta atgtaaggac tcttcttctt ccaaaagcta ccaagagcaa
      481 aacatagacc gtgtcaccgt ggttacagaa gacatcctgg gaggaagcat atctgcctcg
      541 caaataaaga agctggtggc ctccgatggc tcctgtgaag atcagccatg tggtgtcatt
      601 ttcctctcag gatcccaaat atcctgtgga gaacttgctg aacccagaca gtcataaggg
      661 accttggctc agctgccctc gggacaagac tgggcaactg aaagtggagt ttcagctgga
      721 gagagcagtg cccataagct acatcgatgt cgatgatttt ctgattccag cctcaggaga
      781 atcatgggat cgacttcgat tgacctgctc ccaacctttc acacgtcatc aatcctttgg
      841 cctggccttc ctccgagtac gttcctctct ggactctctg tctgaccctg taaaggatcc
      901 ctcatcccct gggagctctg ggcttaatca gaactcttct gataagctgg agtctgatcc
      961 tagcccctgg ctgactaatc cttctatccg gaggaccttc ttcccagatc cccagacgag
     1021 caccaaggaa atttcagcgc tcaagggtat gttgaagcag ttgcagccag ggcctctggg
     1081 gcgggcagcc cgcatggtgc tttctgctgc ccataaggca cctccagcca gtgtcgtaag
     1141 cccaaacaat agccatggag aaccagattc cagtcatccc gagcgtgcag agcccagagc
     1201 agaagaacca aacaggaaga acaatgcaag cagagggaag aggaggaaag tccaggagca
     1261 aaggagaccg ttgtccagct caagctctca gccaaatagg agggcaacag gaaggacaaa
     1321 gcaaagacag caacgacctc aggccaaaag tgatggcagt ggtgtgcagg ctactggaca
     1381 gtgtcccatt tgtacaggtt ccttcagtat tgaggctctt ccccggcatg ctgccacttg
     1441 tggagagagc tccccacccc agccagcttc tcctacctcc ttgtcttcct cagagtctgt
     1501 gctgtgggtg tcttccccag agagctcgcc gccaccatct tcctgggtcc aatgccctat
     1561 ttgtgaatta cagttctcgg caagagaaat agaagaacat gccagcgtgt gtggggaagt
     1621 ttttccagcc tgagcagtga cattctgcta accctttctt gatgttggag cctggggaat
     1681 ggatctcttg tggctaagaa gcattggtcc cctcccttct gtgattacct caggactctg
     1741 cctgcctgag gacactttgg acccagcttg ctccccattc ccgttgccaa ggctgtgtca
     1801 ctatggtacc caattctcat aaggatattt tccccttaga acatatttgg tagaattgat
     1861 gatctctcca aggccttaga acactatcta gaatgtgatt tccaatgccc atttccctga
     1921 aaggaaaacg gaggctcacc tagggggaaa tactgcctga aaattataaa gtcctatgat
     1981 ggtctgggaa gatgagtgag tcttgagcat gacactgaca ctgagtccca tctgaccttg
     2041 accttctata tctttcatgg gtgtctgccc caggtgtaat cagatactgc cctgaaactt
     2101 cacactactt accataggtg tggaatggac gttcagtgac acaaaaaccc ctcacagggt
     2161 tcttaaagga accagagaga tttccttcta aggaataggc gtggctgtaa aagtttgagc
     2221 aaatctcgtt ctaactattt gagatagttg gaccatagtg tctccccaag gtcccctgga
     2281 gctgcgatgg tccaattctg ctttgaagaa ttatgcacgc ttcccttttc cccaggagat
     2341 gtcttcatgt ggcactaaca cccgtccccc ttatccccaa ggtacagggc agggagagag
     2401 cagctggtcc tggtgaaggg agggcttggg gtggggcctt gagtgggaat gaaagagcat
     2461 gtgagccgca gtcaagggag aggcagagca ggagttcaag ccttcagccc ctgcccacag
     2521 aagtgggtgc agccatggat cccctttcgg taagagaccc ttgcttccct cccctcctca
     2581 tcccagtccc cagggggatg cagggacagc ctgctgctgt tggtgggaga gcccctggat
     2641 tcctgatcca gggcctagaa gaaaagagca gggagctgga cctggtagaa caggacgcaa
     2701 cagtaccaag gaggggagat gctctccaag gtagaaggca gagtgagagt atccggtgga
     2761 gggaaagcac cttaaggtcc tactagagtc tttcatagag aaagggttta gggaaagtgc
     2821 agcttaaaga ccctctgtgt gggcatgtct gaacttgtcc ttcagagaga tgagcagcta
     2881 caagatggga actggattcc tgtcggatgt gtataggtta ggtgcctagt gcggccccaa
     2941 ccacctactt taatcacctc tcttcaggga actaacttgg gccctgttat gtctgatttt
     3001 tataagaatg gaagtgggct gagtaaatac tccccatact agcttttcct acatgagtct
     3061 acataataaa atggtgaaca aga
//
LOCUS       NM_001437274            5073 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 2, mRNA.
ACCESSION   NM_001437274 XM_063288138
VERSION     NM_001437274.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5073)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 5073)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 5073)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5073)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5073)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 5073)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 5073)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 5073)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 5073)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 5073)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063288138.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.24359.1,
                                           SRR26643284.8347.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  165425848-165425899 c
            53-177              JAXUCZ010000005.1  165424331-165424455 c
            178-296             JAXUCZ010000005.1  165403843-165403961 c
            297-469             JAXUCZ010000005.1  165392825-165392997 c
            470-698             JAXUCZ010000005.1  165389591-165389819 c
            699-928             JAXUCZ010000005.1  165389275-165389504 c
            929-1108            JAXUCZ010000005.1  165388373-165388552 c
            1109-1258           JAXUCZ010000005.1  165388101-165388250 c
            1259-1348           JAXUCZ010000005.1  165387693-165387782 c
            1349-1570           JAXUCZ010000005.1  165386476-165386697 c
            1571-1667           JAXUCZ010000005.1  165385787-165385883 c
            1668-1798           JAXUCZ010000005.1  165385559-165385689 c
            1799-1849           JAXUCZ010000005.1  165384765-165384815 c
            1850-2017           JAXUCZ010000005.1  165384521-165384688 c
            2018-2139           JAXUCZ010000005.1  165384309-165384430 c
            2140-2283           JAXUCZ010000005.1  165383996-165384139 c
            2284-2383           JAXUCZ010000005.1  165383697-165383796 c
            2384-2562           JAXUCZ010000005.1  165383289-165383467 c
            2563-2675           JAXUCZ010000005.1  165383088-165383200 c
            2676-2754           JAXUCZ010000005.1  165382877-165382955 c
            2755-2922           JAXUCZ010000005.1  165382365-165382532 c
            2923-3046           JAXUCZ010000005.1  165381666-165381789 c
            3047-3192           JAXUCZ010000005.1  165381296-165381441 c
            3193-3325           JAXUCZ010000005.1  165380825-165380957 c
            3326-5073           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..5073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5073
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..52
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            53..177
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            178..296
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            297..469
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    317..319
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             329..3463
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform a is encoded by transcript variant 2;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform a"
                     /protein_id="NP_001424203.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQ
                     LQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
                     LLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
                     LDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVL
                     MKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTL
                     LEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMD
                     FLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALL
                     NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
                     FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
                     LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
                     VNWLAHNVSKDNRQ"
     misc_feature    428..649
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    428..649
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    872..1171
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    872..1171
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1268..1771
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1268..1771
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1838..2380
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1838..2380
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2354..3454
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2354..3454
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2582..2584,2588..2596,2600..2602,2606..2608,
                     2657..2659,2663..2665,2672..2674,2765..2767,2801..2812,
                     2825..2827,2834..2836,3020..3022,3026..3028,3056..3061)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2582..2584,2588..2596,2600..2602,2606..2608,
                     2657..2659,2663..2665,2672..2674,2765..2767,2801..2812,
                     2825..2827,2834..2836,3020..3022,3026..3028,3056..3061)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2786..2791,3092..3097,3101..3103,3107..3109,
                     3305..3307,3314..3316)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2786..2791,3092..3097,3101..3103,3107..3109,
                     3305..3307,3314..3316)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2927..2929
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2927..2929
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2996..3022
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2996..3022
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    3059..3133
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    3059..3133
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            470..698
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            699..928
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1108
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1258
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1348
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1570
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1667
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1798
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1849
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2017
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2139
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2283
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2383
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2562
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2675
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2754
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2922
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3046
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3192
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3325
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..5073
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctcct tgcctcgggg ctgccagctc cgcgggcgca gccgctggac cgggacaaac
       61 ttgccgggtg tacgtacaca tctgctgtgg gctccatccc ttctctggct cagctgggtt
      121 gaactgatgc tcactaaggt cccaccagga ctagagacaa tgctaaggac aaggcagaca
      181 cataaggagc tgagagccag gcagaagtgg gatgaagctc cctgatggca aagcacctgt
      241 aatctcccag gcacaggggc cttggctggt ggtccttctc ggcccatccc aaacaggaga
      301 acaggcctca gagaagtaac acagcaggat gccccctggg gtagactgcc ccatggagtt
      361 ctggaccaaa gaggagagcc agagcgtggc cgttgacttc ttgctgccca caggagtcta
      421 cttgaacttc cctgtgtccc gcaatgccaa cctcagcacc atcaagcagg tgctgtggca
      481 tcgtgcacag tatgagccgt tcttccacat gctcagtgac cccgaggctt atgtgttcac
      541 ctgtgtgaac cagacagcgg agcagcagga gttggaggat gagcagcgga ggctgtgtga
      601 catccagccc ttcctgcccg tgctgcgcct ggtggcccga gagggggacc gcgtgaagaa
      661 gctcatcaac tcacagatca gcctcctcat cggcaaaggt ctccatgagt ttgattccct
      721 gcgggacccg gaagtaaacg acttccgcac taagatgcgc cagttttgcg aagaggccgc
      781 ggctcaccgc cagcagctgg gctgggtgga atggctgcag tatagcttcc ccctgcagct
      841 ggagccctca gccagaggtt ggcgggctgg cttattgcat gtcagcaacc gacccctgct
      901 ggtcaatgtg aagttcgagg gcagtgagga gagcttcacc ttccaggtat ccaccaagga
      961 catgcccctc gcactgatgg cctgtgccct ccgaaaaaag gccaccgtgt tccggcagcc
     1021 tctggtggag aggcctgagg agtatgccct gcaggtgaac gggaggcacg agtacctcta
     1081 cggcagctac cccctctgcc actttcagta catctgtagc tgcctgcaca gcggactgac
     1141 tccccatctg accatggtcc actcctcctc catcctcgcc atgagggatg agcagagcaa
     1201 ccctgccccc caggtgcaga agccacgagt caaacctccc ccgatccctg ccaagaagcc
     1261 ctcctctgtg tccctgtggt ccctggaaca gccattctgc attgagctga ttgagggccg
     1321 caaggtgaat gcggatgaaa ggatgaagct ggttgtgcag gccgggctct tccacggcaa
     1381 tgagatgctg tgcaagactg tgtcgagctc agaggtgaat gtgtgctcag agcccgtgtg
     1441 gaagcagcga ctagaattcg acatcagcat ctgtgacctc ccccgaatgg cccggctctg
     1501 ctttgcactc tatgctgtcg tggagaaggc taagaaggcg cgctccacaa agaagaagtc
     1561 caagaaggcg gactgtccca tcgcttgggc caacctcatg ctattcgact acaaagatca
     1621 gctcaagacg ggcgaacggt gcctctacat gtggccctct gtcccagatg agaaagggga
     1681 actgatgaat cctgcgggta cagtacgtgg taaccccaac acagagagtg ccgctgccct
     1741 ggtcatctac ctacctgagg tggctcccca ccctgtgtac ttccctgctc tggagaagat
     1801 cctggagctg gggcgtcacg gggagcgtgg gcgcatcaca gaggaggagc agctgcagct
     1861 gcgggagatc ctggagcggc ggggatctgg ggaactgtac gaacatgaga aggacctggt
     1921 gtggaagatg cgtcacgaag tccaggagca tttcccagag gcgctggccc gcctgctact
     1981 ggtcaccaag tggaataaac atgaggatgt ggcccagatg ctctatttgc tgtgctcctg
     2041 gcccgagctt cctgtgctga gcgccctgga gcttctggac tttagttttc ctgactgcta
     2101 cgtgggttcc ttcgccatca agtccctacg gaagctgacg gatgacgagc ttttccagta
     2161 ccttctgcag ctggtacaag tactcaaata tgagtcctac ctggactgcg agttgaccaa
     2221 attcttgttg ggccgagccc tggctaaccg caagatcggg cacttcctgt tctggcacct
     2281 ccgctctgag atgcatgtac cgtccgtggc cctgcgtttt ggcctcatca tggaagccta
     2341 ctgcagaggc agcacccacc acatgaaggt gctgatgaag cagggggagg cactgagcaa
     2401 gcttaaggcc ctgaatgact ttgtgaaggc gagctcgcag aagaccacca agccccagac
     2461 caaggagatg atgcatatgt gtatgcgcca ggagacttac atggaggcgc tgtcccacct
     2521 gcagtctccc ctcgacccca gcaccctgct ggaggaagtc tgtgtggagc agtgcacctt
     2581 catggactcc aaaatgaagc cattgtggat catgtacagc agcgagaagg caggcggtgc
     2641 cggcagcgtg ggcatcatct ttaagaacgg ggatgacctc cgccaggaca tgctgactct
     2701 gcagatgatc cagctcatgg acttcctatg gaagcaggag ggcctggacc tgaggatgac
     2761 cccctatggc tgcctcccca ccggagatcg cacaggcctc attgaggtgg tcctccactc
     2821 ggacaccatc gccaacatcc agctgaataa aagcaacatg gcagccacgg ctgcgttcaa
     2881 caaggacgct ctgctcaact ggctcaagtc taagaaccct ggggaggctc tggatcgggc
     2941 cattgaggaa ttcaccctct cctgtgctgg ctactgtgtg gccacatatg tgctgggcat
     3001 cggtgaccgg cacagcgata acatcatgat cagagagagt gggcagcttt tccacattga
     3061 ctttggccac tttctgggga acttcaagac caagttcggg atcaaccggg agcgtgtccc
     3121 cttcattctc acctacgact ttgtccacgt gatccagcag gggaagacta acaacagtga
     3181 gaaatttgaa aggttccgag gctactgtga acgagcctac accatcctgc ggcgtcacgg
     3241 gctgcttttc cttcatctct tcgccctcat gcgcgcagca ggtctgcctg agcttagctg
     3301 ctccaaagac atccagtatc tcaaggactc tctggcacta gggaagacgg aggaagaagc
     3361 actaaagcac ttccgggtga agttcaatga agctctccgg gagagctgga aaaccaaagt
     3421 caactggctg gcacacaatg tgtccaagga taacaggcag taagaggcgc ccccctgggc
     3481 gtcacattcc cctgggcgtc acatggcagt tccctggttc cctccgggct ctcagccata
     3541 gaggtaaact gtcagtcctg gagaccaggc atgctcagtg gtcatcaaag gggccccaga
     3601 cctgaactgt ccctcacaga gaagaaccac acaactgctt cttgtttaca ctggttattt
     3661 atttatgact cgaaatgttt aaggaacaga atagccataa atggaagtgc atttttgtgc
     3721 aggggagggg tgctgtcctc gtgacccccc ctccctcagc actgtaaaca gcaccttgag
     3781 gatcgtaccc ctagtcttcc aacctgtggg tcttggcccc ccaaaggcag ttttgggggc
     3841 caccttccca ggctcccagc cggctgccta gaacaagcct ggcagtcacc tggtgcctcc
     3901 cacgcagaca ggacacctca atcctcagct cagctcacct ccgccacctt catgtggccc
     3961 accctcggcg acctccatct accaagcctc cggcagctcc tgaggaagcc aggagcttcc
     4021 ctctagactc aggcacactt gctctgcact gctgaagtga caacctcttg ggtacggaaa
     4081 caccctcacc ttttatttgc gggtaagaac atgattatgt aaactctgta tagaatagcc
     4141 ggggtaaagg acctggcttc cactacagat agctgtgttc tgggcctcaa aacactagag
     4201 attggtgccc gatttagtgc ggtgtggtcg tgaatccaga caaagggcaa gcctgaacgg
     4261 agtcctcttc gcaatttgtg tgagaaccgc acacaaaggc agctttctgg aaggacagga
     4321 ctgatgtctc ccagagctgc cattctcaga aggcagctgg ggtcccgggt tctgaagtgt
     4381 gcgcgaggag gaggaccaag tttagtagtc tgggcgactg gagcatctcc agaaatgcag
     4441 ggtctccacc ccctcccagg tatccaaacc tactttgggc tgtagagcca gtcacctggc
     4501 tttttagaga gcccagctca gtggtgcaca tgcataaaac gtgccatccc gagcccaccg
     4561 tgatgcatca gctgccgcct caggacctgg ctctcccggt aacatcctga gacttgcaga
     4621 accatcaccg ccgtcttgct ggcagcccag aacatggctg ctcaaggaag ccaggtgtcc
     4681 gctctttcac gatgatgaac tgagggtcca gcagtggttg gtgcctccag ggcacttgct
     4741 gaacccttag tctgccccaa ctctgaaata ggaagtgtgc gtgcgtgtgc gtgcgtgtgc
     4801 gcgtgtgtgc cgtgttattt attgaaaaga gtctaggtgc tccctggtgt ggctgcagat
     4861 tctgcagagg ctcagccttt ctgggttggg tatgtggtct gtgtacctgg ctggaaaagt
     4921 attttctatt tttttttttt aaaagttgtt ctacgtttct gtagggggga aggtagattt
     4981 cctctcactg atgtgggctg agatcagtct gtgcaaccct gacacgtccg gtaaagacag
     5041 gtgaaaagaa ataaaaatct ttttatgttc tta
//
LOCUS       NM_001437373            4490 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 3, mRNA.
ACCESSION   NM_001437373 XM_006254911
VERSION     NM_001437373.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4490)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 4490)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 4490)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 4490)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 4490)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 4490)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 4490)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 4490)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 4490)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 4490)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254911.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54695.1,
                                           SRR26643298.74677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1355           JAXUCZ010000018.1  70152876-70153043
            1356-1655           JAXUCZ010000018.1  70153375-70153674
            1656-1793           JAXUCZ010000018.1  70153761-70153898
            1794-1925           JAXUCZ010000018.1  70154230-70154361
            1926-1987           JAXUCZ010000018.1  70154449-70154510
            1988-4490           JAXUCZ010000018.1  70155741-70158243
FEATURES             Location/Qualifiers
     source          1..4490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4490
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2027
                     /gene="Mbd1"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 3"
                     /protein_id="NP_001424302.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELQPYTNQRQNRKCGACAACLRRMDCGHCDFCCDKPKFGGSNQKRQKCRWRQ
                     CLQFAMKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPPGP
                     VQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPGWV
                     VALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDGEE
                     NKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRSKDLKKPGAKMQ"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1200..1340
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1200..1340
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1355
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1655
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1793
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1925
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1987
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..4490
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctacag ccctatacga
     1201 accagcggca gaaccgcaag tgtggggcct gtgcagcctg cctacggcgg atggactgtg
     1261 gccactgcga cttctgctgt gacaagccca aattcggggg cagcaaccag aagcgccaga
     1321 agtgtcgttg gcgccagtgc ctgcagtttg ccatgaagcg gctgctgccc agtattgggc
     1381 cagggtctga ggaggaagca agattgcttc cacatcatac ccaccaaaag aggtctgctt
     1441 ctactcgaca gctgcaactg agctctccct taaaggctcc tttggctgtg gtcacaaccc
     1501 caccgggccc tgtccaagat tcagggaagc ggcaagcagg tagtggcttt gtactgcccc
     1561 aacctgacac agaccttgtg tatttacaag agggtaccag cagtctcatg caggtgcctg
     1621 gccctgctgc agcttccaca gaaaacccag cacaggagac ccagggctct gccccaggtt
     1681 gggttgtggc cttgccccag gtgaagcaag agaaggcgga tgccccagag gagtggacag
     1741 cagtcacaac cttcctgact tcttccacgg tgcagcctgg cttccttagc aaggcgtcag
     1801 gcctggaccc tccacctgtg aaacgagagc cccctggccc tgaggaggat ggagaagaga
     1861 acaaagaaga tgatgtctct gaatcagctc cagcagaaga gataggaggg attggcaccc
     1921 cagtgatcac ggagattttc agcctgggtg gaacccgcct ccgggatgca gaagcctggt
     1981 tgccaaggtc caaggacctt aaaaaacccg gagctaaaat gcagtagact ggaggcctct
     2041 gctgactgta ggctgaaggt ggtatttgca gaccggcttt gtggaaacaa ccctgatcct
     2101 aaaggggctg ggccctggcc cggctgcaga gcttgtgtgg gaaccaactc taggaggaaa
     2161 acctacaagc acaaccaagg agcaggcctg ctcagtcctt ggaccttaga ggaagcaagc
     2221 tggagaggaa gagaaagagt agaaggctgg tggaatgtct gctcctccgt ggatctcgat
     2281 gcagtgagaa gttggatggt agggtaggga agggtagctg aagccactgc agacagctca
     2341 cacaagccac ctgcatagcg tccgttggtg gcttctggat gacctggcag tgtgtctgaa
     2401 cattttctca gggaaacagc agttgcaatg ctatgtgaat aaagggagaa aggagttgtt
     2461 gtttgctgag ctcctgtgga gccaagcgac tctagccctc acagtagtcc ttaggaacac
     2521 actgacgtta cgcacttttg caggcaggaa atagattcag aagagacgaa ctttcccggt
     2581 gttacacagc tagtgttgct acattctaga aacatgccta ggctataaaa gctttgttct
     2641 ttaagccact aaattgttaa ctgcagtctt ctgtgcaata atgtacgtta caataacagt
     2701 ttcagtgact ttgaaacagc agtggggcac tctgagcact gtaagatacc cgttccactt
     2761 ggcctctgtg gtctaggaga tgcccaggct gtgggtgaac gggtcacctt ctcgttaggc
     2821 cctggatgct gcatccgttc cctttgttct gagtgtgctc cccaccgctg gcccacagtt
     2881 tgctatgccc agacgctctc acttcaggca gagcagtgca tggcactaaa gctgtcagcc
     2941 tgacccctct tttcctgaca gcttctctct gatgacctct gtgcttgttt cctgccccca
     3001 gcccaaacgt ttgttagaag actgagtgga tttatgcact gagtcctgcc cagagaccag
     3061 tctcgactca gccgtacctc attttccatc cttaaatgcc aaaaagtgtg aagtttgtta
     3121 cttagccagc tttacgggcg aggactgggc acctcgtcat atgtgtgttc tgtgcacccc
     3181 gtgtgttagc tttgtcccag ctctgctgct ttagtaatgc agatatgggt cactctgttt
     3241 ccagtccaca agacagaggt ctgccacctt gttttctgcc tttgccctgc tttgctagtt
     3301 gtgtactgga tcattctgct cttcaaccct agagctcacc acttgtccct agtatcctgg
     3361 tagttcggac agtggtgtat taacttgtct ttggttggca tttgacttgt gaatgaagat
     3421 tctgattact atatgtgttt gactagggga caatcaaaag atcagaacca ctacaacaaa
     3481 ggctgatgtg tgcatgttaa ggatgtttta tgttatgtaa tttgcggaga tggcttagcc
     3541 tctagggctg tcatttgtat ataatactag gacttaaagt attcaggacg gggagtcagg
     3601 aagggaaggt ggaaggacat ggaaaccttg aacaagagtt ggaattcaag aagatggcct
     3661 ggaacccgtg cagtgtctca ccgcctccag cttcaatgat gtttgtatcc tgcagaagaa
     3721 gctagtgtcc ttaggagcat ctggcctagg actagagaag ctaaaggaag acccagggaa
     3781 attgtagccg ctgaaggcct ggctgtagga cttgctgttt ccccgtacca aggtgagaca
     3841 gcagactaat gacagcttgt atgaactgca acatgcttgc tgtccctgca ccaaccttcc
     3901 aagtgttaag aacagcctgc tgctgctgct tcacttctac tagccacagc ctttctgtgg
     3961 atgttcttaa ctggaatgta tggggaagga tcccaggaag catagtctag tcaaggtgac
     4021 atgttagaaa gccaccttac catgactcag ctccatgagg tctcaccact cacctgagga
     4081 taacgtaaca aaactacatt gctgaaaagg taaagctgga gaccatggat ttcgtgatgg
     4141 tcccagcaag taaagaaatc atgtcccgct gatccagaac agtcttgctg atctcagctg
     4201 tatttgtgtt attcatccaa gtcttgaaag cttagctcac tgtacataat actgagattc
     4261 agaagtgcag ttttataaaa tgcatcaata tatattacaa gtgataaaat agctccggtt
     4321 tactatggac ttcgatgctg aaatatagaa ttgagtatac tgtggagaag ccagtccttt
     4381 tttgagtttt tttttcaaag tagtatagta gttggaaaca acttaatcat ttctatttct
     4441 aaggtgttct attgtaaagt tattttaaaa caaattctcc tgttctatta
//
LOCUS       NM_001107140            6478 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus kinetochore associated 1 (Kntc1), transcript
            variant 2, mRNA.
ACCESSION   NM_001107140 XM_001074897 XM_222157
VERSION     NM_001107140.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6478)
  AUTHORS   Civril,F., Wehenkel,A., Giorgi,F.M., Santaguida,S., Di Fonzo,A.,
            Grigorean,G., Ciccarelli,F.D. and Musacchio,A.
  TITLE     Structural analysis of the RZZ complex reveals common ancestry with
            multisubunit vesicle tethering machinery
  JOURNAL   Structure 18 (5), 616-626 (2010)
   PUBMED   20462495
REFERENCE   2  (bases 1 to 6478)
  AUTHORS   Chan,G.K., Jablonski,S.A., Starr,D.A., Goldberg,M.L. and Yen,T.J.
  TITLE     Human Zw10 and ROD are mitotic checkpoint proteins that bind to
            kinetochores
  JOURNAL   Nat Cell Biol 2 (12), 944-947 (2000)
   PUBMED   11146660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001107140.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000012.1  38500362-38500456   c
            96-269              JAXUCZ010000012.1  38497839-38498012   c
            270-390             JAXUCZ010000012.1  38495972-38496092   c
            391-506             JAXUCZ010000012.1  38494374-38494489   c
            507-579             JAXUCZ010000012.1  38493836-38493908   c
            580-657             JAXUCZ010000012.1  38492937-38493014   c
            658-692             JAXUCZ010000012.1  38491527-38491561   c
            693-786             JAXUCZ010000012.1  38489505-38489598   c
            787-839             JAXUCZ010000012.1  38488544-38488596   c
            840-955             JAXUCZ010000012.1  38488164-38488279   c
            956-1021            JAXUCZ010000012.1  38485384-38485449   c
            1022-1097           JAXUCZ010000012.1  38485222-38485297   c
            1098-1220           JAXUCZ010000012.1  38483618-38483740   c
            1221-1310           JAXUCZ010000012.1  38483438-38483527   c
            1311-1372           JAXUCZ010000012.1  38481100-38481161   c
            1373-1484           JAXUCZ010000012.1  38479512-38479623   c
            1485-1628           JAXUCZ010000012.1  38477886-38478029   c
            1629-1685           JAXUCZ010000012.1  38477301-38477357   c
            1686-1787           JAXUCZ010000012.1  38476996-38477097   c
            1788-1904           JAXUCZ010000012.1  38475497-38475613   c
            1905-2048           JAXUCZ010000012.1  38475259-38475402   c
            2049-2147           JAXUCZ010000012.1  38473773-38473871   c
            2148-2251           JAXUCZ010000012.1  38472421-38472524   c
            2252-2351           JAXUCZ010000012.1  38472193-38472292   c
            2352-2486           JAXUCZ010000012.1  38471746-38471880   c
            2487-2606           JAXUCZ010000012.1  38470582-38470701   c
            2607-2679           JAXUCZ010000012.1  38469250-38469322   c
            2680-2747           JAXUCZ010000012.1  38468177-38468244   c
            2748-3028           JAXUCZ010000012.1  38467023-38467303   c
            3029-3201           JAXUCZ010000012.1  38466489-38466661   c
            3202-3299           JAXUCZ010000012.1  38465945-38466042   c
            3300-3438           JAXUCZ010000012.1  38464463-38464601   c
            3439-3495           JAXUCZ010000012.1  38463233-38463289   c
            3496-3659           JAXUCZ010000012.1  38462355-38462518   c
            3660-3764           JAXUCZ010000012.1  38461776-38461880   c
            3765-3893           JAXUCZ010000012.1  38458868-38458996   c
            3894-4010           JAXUCZ010000012.1  38457367-38457483   c
            4011-4120           JAXUCZ010000012.1  38456883-38456992   c
            4121-4325           JAXUCZ010000012.1  38454718-38454922   c
            4326-4497           JAXUCZ010000012.1  38449273-38449444   c
            4498-4556           JAXUCZ010000012.1  38449135-38449193   c
            4557-4770           JAXUCZ010000012.1  38448817-38449030   c
            4771-4844           JAXUCZ010000012.1  38448214-38448287   c
            4845-5055           JAXUCZ010000012.1  38447790-38448000   c
            5056-5165           JAXUCZ010000012.1  38447567-38447676   c
            5166-5212           JAXUCZ010000012.1  38443844-38443890   c
            5213-5291           JAXUCZ010000012.1  38441686-38441764   c
            5292-5410           JAXUCZ010000012.1  38440119-38440237   c
            5411-5546           JAXUCZ010000012.1  38439607-38439742   c
            5547-5642           JAXUCZ010000012.1  38438956-38439051   c
            5643-5699           JAXUCZ010000012.1  38438356-38438412   c
            5700-5754           JAXUCZ010000012.1  38436256-38436310   c
            5755-5818           JAXUCZ010000012.1  38435991-38436054   c
            5819-5948           JAXUCZ010000012.1  38434225-38434354   c
            5949-6038           JAXUCZ010000012.1  38433440-38433529   c
            6039-6184           JAXUCZ010000012.1  38432818-38432963   c
            6185-6275           JAXUCZ010000012.1  38432071-38432161   c
            6276-6478           JAXUCZ010000012.1  38429925-38430127   c
FEATURES             Location/Qualifiers
     source          1..6478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15-q16"
     gene            1..6478
                     /gene="Kntc1"
                     /note="kinetochore associated 1"
                     /db_xref="GeneID:304477"
                     /db_xref="RGD:1307905"
     exon            1..95
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Kntc1"
                     /note="upstream in-frame stop codon"
     exon            96..269
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..6293
                     /gene="Kntc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinetochore-associated protein 1; kinetochore-associated
                     protein 1-like"
                     /codon_start=1
                     /product="kinetochore-associated protein 1 isoform 2"
                     /protein_id="NP_001100610.1"
                     /db_xref="GeneID:304477"
                     /db_xref="RGD:1307905"
                     /translation="MWNNIELLTSDDTGSGFLNVGSRKESVTALYQVDLLGKISSEKT
                     SLSPKIQACSLSDGFIIVADQSVILLDSTCRSLQLFLIFDTDVDVVGLCPEGKFLFVG
                     ERSGNFHLIYVTSKRTLFTKAFVEKAEDERTYRSLVIEKDGSNEGTYYMLLLTNNGFF
                     YITNLQLSQIEQAIENTDLDSAKKGTGSCAFSKWEPDSTKKDMSLKNFVDTDIIRGAK
                     SFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPIEQFLLTTEADSPSSVTCLCED
                     SVSNLELRYLTEVLPENRLSRLLHKHRFADAESFAIQFGLDVELVYKVKSNDILEKLA
                     LISDKSEQSEWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRVL
                     KAHAKLTTFYGAFGPEKFSGSAWVEFLNNEDDLKDIFVQLSEGNFDCAQYLWLRHRAD
                     FESKFDVKMLENLLNSISTQIPVEKLCSWFKNDVIPFVRRIVPEGQNILAKWLEQASR
                     NLELTDKANWPENGLQLAEVFFTAEKTDKFGFSSSWHWISLDYQNTEEVQQLRTLVSK
                     LQELIILHRKYNCRLALSEFEKENATTVVFRMFDRVSAPELIPSVLEKFVRVYIREQN
                     LQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKA
                     VVPWSAAVEQLVRQHLEMDHPKVKLLQESYRLMEMKKLLRGYGIREVNLLNKEIMRVV
                     RYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRVIDLIDRDQGEDCLLLLRSLPPSEA
                     EKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSMDILKILCDIQKDNLQKKDDAE
                     EFLKRFKMVASLQENFEVFLPFEDYSDTGLVAGLREQYIKAQENAQAEHKFRGPPGPT
                     PAMGTNASVKSKLHRQALVLQVSTQELEAEMALRALKDGKVAVALSKCRDLLKHYCNA
                     DTGRLLFVVCQKLCHMLADDVPMVAPVGLNLPSEIHDLTCHAVTICSPDFLLDVLELS
                     KYTLTAVELCRQCQMDDCGILMKAAVGTHKDPYEEWSYSDFFSEDGIVLESQVVLPVI
                     YELISSVVPLAEGKRRPLDSISLPYCSTSEGENLILPLVSSISALLRNLQESSQWELA
                     LRFVVASFGTCLQHSVSNVMSMSLSEKLLGKSTLASSRQIIMELKEKSIAFIRGSATT
                     LLHKVFNCRLVDLDLALAYCTLLPQKDVFENLWKFIDKAWQNYDKILALSLVGSRLAN
                     LYQDVETGLRFHELSIDAKWGIRLGKLGISFQPAFRQNFLSKKDLIKALVNNIDMDTS
                     LILEYCSTFQLDSDAALRLFIETLLRNTTSQSQGGDAPEPTQHQHSKLLQKATEMVPL
                     LKSTKDLVISLTEILYKALNLLRHLKSYRRMSPPVDLEYQYMLEHLITLPPAAQTRLP
                     FHLILFGTAQNFWKILSSELSEESLPTLLLISKLMKFSLDTLYVSTAKHVFEKNLKPK
                     LLKSAQARSSVMSKEVDKLVQTLESYLLSIVNPEWAVAIAISLTQEIPEGPFKMTSLK
                     FCLYLAERWLQNIPPQDETCEKVKALQKKLYLQFRLSGTEAVLIAHKLNDQEYLRVVG
                     KPAHLIVSLYEHPSISERLCTTSGKDYPDIHAAAKEIAEVNEINLEKIWDMLLEKWLC
                     PSTAPGEKASEFFELEEDEVLHRVVYLLQARPIDYSSRMLFVFATSATSTLGIRQLTF
                     AHRARALQCLLYLADKETIESLFKKPTEEMKSYLKCITFLASFETLNIPITYELFCNS
                     PKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVL
                     SCISSVHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCESLVAILECPVSDDL
                     DMMGVAKQYVQLELPAFALTCLTLMPHSEKRHQQIKNFLNSCDAQIILQQLEEHMNAG
                     QLAGLSQQIRSLVLNHVVNKKEFGILAKTKYFQLLKRHVINTDNVTELVNYLANDLSL
                     DEASSLITEYSKHCGKPVPADTAPSEILKTFLGS"
     misc_feature    1278..>1997
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    1278..>1997
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    4413..6056
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    4413..6056
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     exon            270..390
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..506
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..579
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..657
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..692
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..786
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..839
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..955
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1021
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1097
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1220
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1310
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1372
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1484
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1628
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1685
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1787
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1904
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2048
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2147
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2251
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2351
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2486
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2606
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2679
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2747
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..3028
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3201
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3299
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3438
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3495
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3659
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3764
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3893
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4010
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4120
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4325
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4497
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4556
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4770
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4844
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4845..5055
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5165
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5212
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5213..5291
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5292..5410
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5411..5546
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5642
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5643..5699
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5700..5754
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5755..5818
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5819..5948
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6038
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6184
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6185..6275
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6276..6478
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcaggg aacctaaaat gagtaggggc ggttgtgtca gtaaggaaga agtgtgaaac
       61 acttgagaat tctcttttaa tttcttcagc tgcagggaga tcgtggcgcc ttccttcctc
      121 tgaaggacag tcttggggac atgtggaaca atatcgagct gctaaccagc gatgacacgg
      181 gaagtggatt cctcaatgtt ggctcacgaa aagaaagcgt gactgcactg taccaggtgg
      241 acttgcttgg gaagatctcc tctgagaaga cctcactgag tcccaagatc caagcatgca
      301 gcttaagcga tgggttcata atcgtggcag accagtcagt gatactgctt gacagtacat
      361 gcagatccct tcagctgttt cttatattcg acactgacgt ggacgtggtt ggcctgtgtc
      421 cagaaggaaa gtttctcttt gtgggggaga gaagcggcaa ctttcatctt atctatgtaa
      481 catcgaagcg aactctgttc accaaggcct ttgtggagaa agccgaggat gagcgtactt
      541 accggagtct cgttattgag aaagatggtt caaatgaagg tacctattat atgttgcttc
      601 tgacgaacaa cggatttttt tacattacaa acctccagct ttcacaaatt gaacaagcaa
      661 ttgagaacac agacttggat tcagccaaga agggaactgg tagctgtgcg ttctcaaaat
      721 gggaaccaga ttctaccaag aaagacatgt ctcttaagaa ctttgtggac acggacatta
      781 ttagaggtgc aaagtcattt cagctgatcg acaatctgct ttttgtgctt gatactgata
      841 atgtgctgag cttgtgggat gcttatactc tcactccggt gtggaactgg ccttctcttc
      901 ccatagagca gtttctcctc acgacagaag cggactcccc ctcttcagtt acctgcctat
      961 gtgaagactc tgtgtctaac ttagaactta ggtacctcac agaggtgtta ccagaaaaca
     1021 gactgagccg gctacttcac aagcacagat ttgccgatgc cgagagcttt gccattcagt
     1081 ttggactgga cgttgagctt gtttataagg tcaaatcaaa tgatatattg gagaagctgg
     1141 ctttgatctc agacaagagc gagcagtccg aatggcagca acttgtagat gaagccaaag
     1201 aaaacctatg caaaatccag gacgatgact tcgtggtgaa tttctgcctc aaggcccaat
     1261 gggtcaccta tgaaaccacc caggaaatgc tcagttatgc caaaaccagg gtgctaaaag
     1321 ctcatgcgaa gttaactaca ttttatggag catttggacc agagaaattc agtggtagcg
     1381 cttgggttga attcctgaat aatgaagatg acctcaagga tatttttgtg cagctaagtg
     1441 agggaaactt cgattgtgct cagtatcttt ggcttagaca tcgggctgac tttgaaagca
     1501 agttcgacgt gaaaatgctg gagaatttgc tgaactcaat atctacacaa atccccgtgg
     1561 aaaaactctg ttcctggttt aaaaacgacg tgattccctt tgtgaggagg attgtgcccg
     1621 aaggacaaaa cattcttgca aaatggctgg aacaagcctc gaggaaccta gagctaacgg
     1681 ataaggcaaa ctggccagaa aatggacttc aactggcaga ggtcttcttc actgcagaaa
     1741 aaactgacaa atttggattc tcgtcctctt ggcactggat ctccttggat tatcaaaaca
     1801 cggaggaagt ccaacagttg cggacactgg tgagcaagtt gcaggagctg atcatcctgc
     1861 ataggaaata caactgcagg ctggccctct ctgagtttga gaaggaaaat gccaccactg
     1921 tggtgttccg catgttcgac agggtctcgg ccccagagct gatcccttct gtcttagaga
     1981 agttcgtgag agtttacatt cgggaacaga atttgcaaga ggaggaactt cttttgctct
     2041 atatagagga cttactaaag aggtgcagct ctaagtcaat gacactgttc gacaccgcgt
     2101 gggaagcgaa ggccatggcc gtgataagat gcttgtctga cacagatctc atcttcgacg
     2161 ctgtgctgaa gataatgtac aaggccgtgg ttccctggag tgccgctgtg gagcagctgg
     2221 tgagacagca tctggaaatg gaccacccca aagtcaagtt attacaggaa agctacagac
     2281 tcatggagat gaagaaactc ttgcgaggct atgggataag agaggtgaat ctcttgaaca
     2341 aggaaataat gagagtggtc cgctacattc tcaagcaaga catcccgtcg tctttagaag
     2401 atgctctgaa ggtggcccaa gggtacaggc tgtccgacga cgaaatctac agtctaaggg
     2461 tcattgatct gattgaccga gatcaggggg aagattgtct cctgctcctg aggtctctgc
     2521 ctcccagtga agctgagaaa accgcagaaa gagtcatcat ctgggctcga ctggcactgc
     2581 aagaagagcc tgacggttct gaagaggaca aggcctggag aatatctgtg gcgaagacat
     2641 cgatggatat tctcaaaatc ctgtgtgata ttcagaaaga caatctgcag aagaaggatg
     2701 acgctgaaga attcctgaag cgatttaaaa tggttgctag tttacaggag aacttcgagg
     2761 tcttccttcc atttgaggat tacagcgaca ctggcttggt agctggcctt cgagaacagt
     2821 acattaaggc acaggagaat gcacaggctg agcacaaatt caggggaccc ccagggccca
     2881 ccccggccat ggggacaaac gcgagcgtca agtcaaagct gcacagacag gccctggtcc
     2941 tgcaggtgtc tacacaggaa ctggaggcag agatggctct gagagcccta aaggacggaa
     3001 aggtggcagt agccctgagc aaatgcaggg atttacttaa gcattactgc aatgccgaca
     3061 cagggcgatt gctgttcgtg gtgtgtcaga agctctgtca catgctggct gacgacgtcc
     3121 caatggtagc cccagtagga ctcaaccttc cttctgagat ccatgatctc acatgccacg
     3181 ctgtcaccat ctgcagtcca gatttcctgc tggatgttct agaactgagt aaatacactt
     3241 tgaccgctgt ggagctttgc agacagtgcc agatggatga ctgtgggatt ctgatgaagg
     3301 ctgccgtcgg gacacacaag gatccctatg aagagtggtc ctacagtgac ttcttcagtg
     3361 aagacggaat tgttcttgag tcacaggtgg tgctgcctgt catctatgaa ctgatctcat
     3421 cagtggtgcc cctggcagaa ggcaaaagac gccctttgga ttctataagc ttgccatact
     3481 gttccaccag tgaaggagaa aaccttattc tcccccttgt cagttccatc tctgctctgc
     3541 tccggaacct tcaggaatcc agtcagtggg aactggcgct caggttcgtg gtggcctcct
     3601 ttggtacctg cctgcagcac tctgtgtcta acgtcatgag catgagttta agtgagaagc
     3661 tacttggcaa gagcacactg gcgagctcaa ggcagatcat tatggaactg aaagagaagt
     3721 ccatcgcatt catcagagga agcgccacga cactcctgca taaagtgttt aactgtcgtc
     3781 tggtggatct ggacctcgcc ttggcttact gcactctctt accgcaaaag gatgtgtttg
     3841 aaaacctctg gaagttcata gataaagcgt ggcagaatta cgacaaaatc ctggcattat
     3901 ctctggtagg ctctcggctg gcaaatctct accaggatgt tgaaacagga cttcggttcc
     3961 atgaactcag tatcgatgcc aagtggggaa ttcgccttgg taaacttggt atttcctttc
     4021 agccggcttt cagacaaaat ttcctcagca agaaagacct tattaaagct ctcgtgaata
     4081 acatagatat ggacacaagc ctcattctgg agtattgcag cacttttcag ctggactcgg
     4141 acgccgccct tcggctgttc attgagaccc tgctccgtaa cactaccagc cagagccagg
     4201 gaggggatgc cccggagccc acacagcatc agcattccaa actcctgcag aaagccacag
     4261 agatggtccc cttgctgaag agcacaaagg acctggtgat cagtcttacc gaaatccttt
     4321 ataaggctct gaatcttctg agacacttga agtcatacag aagaatgtcc ccaccagtgg
     4381 acctcgagta ccagtacatg ctggagcact tgataacgct gccaccagcc gcccagacta
     4441 gactgccctt tcacctaata ttatttggca cagcacagaa cttctggaaa attctctcct
     4501 cggagctcag cgaagagtca cttccaaccc tgctcttaat ctctaagcta atgaagttct
     4561 ccctagatac tctctatgtg tctaccgcca aacacgtttt tgaaaaaaac ctgaagccaa
     4621 agctcctgaa gtcagcacaa gccaggtcct ccgtgatgag caaggaagtg gataagctcg
     4681 tgcagaccct ggagtcatac ctcctgtcca tcgtcaaccc cgagtgggcc gtcgccattg
     4741 ccatcagtct cacccaggag atcccagaag gccccttcaa gatgactagt ttgaaattct
     4801 gcctgtattt agctgagaga tggctacaaa acatcccacc tcaggacgag acatgcgaaa
     4861 aggtcaaggc cttgcagaag aagctgtacc tccagtttcg gctctcggga acggaggccg
     4921 tgctcatagc ccacaagctg aatgatcagg aatatttaag agtggtaggg aagccagcgc
     4981 acctcatcgt gagcctctat gagcatccca gcataagcga aagactttgt accacatctg
     5041 gcaaagatta tcccgatatt cacgcagcag ctaaagagat agccgaagtc aatgagatta
     5101 acttggaaaa aatatgggac atgctgttgg agaaatggtt gtgtccctca acggcgcccg
     5161 gtgagaaagc atcggagttc tttgagcttg aagaggatga agtgctacat agagtcgtgt
     5221 atctcctcca ggctcgcccg atcgattata gctccaggat gctgttcgta ttcgccactt
     5281 cagccacaag tacactgggc atacggcagc taacgtttgc ccacagagca cgagctcttc
     5341 agtgcctcct ctacttggct gacaaggaaa ccatagaatc tctcttcaaa aagcccaccg
     5401 aagaaatgaa atcctatctg aaatgtataa ctttcctggc atcattcgag acattgaata
     5461 ttcccatcac atatgaatta ttctgcaaca gtcccaaaga aggcatgatt aagggcttgt
     5521 ggaagaacca cagccacgaa cctatggcag tacggttggt ggcagagctt tgcttagaat
     5581 acaaaatcta tgacctgcag ctttggaatg ggctcctgca gaagcttctg ggcttcaaca
     5641 tgatccctta cctaaggaaa gtcctgtcct gcatttctag cgtccattcc ttatggcagg
     5701 ttccctactt cagcaaagct tggcagcgtg taatccagat ccctctgctc tcagcttcct
     5761 gtcctttaag gcccagtcag ttagcagact gttgtgagag tctcgtcgcc atccttgaat
     5821 gtccagtttc agatgacctc gacatgatgg gcgtcgccaa gcagtatgtc cagttagagc
     5881 ttcctgcttt tgcactgacc tgtctgacgc tcatgcccca ctctgaaaaa agacatcagc
     5941 agatcaagaa tttcctgaat tcatgtgatg ctcagatcat tttacagcaa ttggaggagc
     6001 atatgaacgc tggccagtta gcagggcttt cacagcagat tagaagtctg gttctgaatc
     6061 atgtcgtaaa taagaaggaa tttgggattt tggcaaagac aaagtatttt cagttgttga
     6121 aacggcacgt gatcaacacc gacaacgtca ctgagttggt aaactattta gcaaatgact
     6181 tgagtttgga tgaagcatca tctctgataa ctgagtattc aaagcattgt gggaagcctg
     6241 tgccagcaga cacagctccc tctgagatcc tgaagacatt ccttggatcg tagtcaaaca
     6301 aacaagtttt tgaaaccaag aggaaggtcg gagtctgctg ctaattaatc atatttattg
     6361 tagtgtacaa attgtgcaat ctgtattttg ttatcctgca aggaataaat aaaacttcaa
     6421 tattgacatg gctgacctga atatctcaca gggtttgtta ataaatattt tgatgttg
//
LOCUS       NM_001437340            2853 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus carnosine dipeptidase 1 (Cndp1), mRNA.
ACCESSION   NM_001437340
VERSION     NM_001437340.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Chakkera,H.A., Hanson,R.L., Kobes,S., Millis,M.P., Nelson,R.G.,
            Knowler,W.C. and Distefano,J.K.
  TITLE     Association of variants in the carnosine peptidase 1 gene (CNDP1)
            with diabetic nephropathy in American Indians
  JOURNAL   Mol Genet Metab 103 (2), 185-190 (2011)
   PUBMED   21393041
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Kilis-Pstrusinska,K., Zwolinska,D. and Grzeszczak,W.
  CONSRTM   Study Group
  TITLE     Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic
            kidney disease progression in children and young adults? results of
            a family-based study
  JOURNAL   Arch Med Res 41 (5), 356-362 (2010)
   PUBMED   20851293
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S.,
            Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D.,
            Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C.
            and Smirnova,T.
  TITLE     Sequence identification and characterization of human carnosinase
            and a closely related non-specific dipeptidase
  JOURNAL   J Biol Chem 278 (8), 6521-6531 (2003)
   PUBMED   12473676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35360.1,
                                           SRR22582416.268304.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000018.1  80291601-80291811   c
            212-413             JAXUCZ010000018.1  80282443-80282644   c
            414-563             JAXUCZ010000018.1  80280876-80281025   c
            564-726             JAXUCZ010000018.1  80279338-80279500   c
            727-815             JAXUCZ010000018.1  80277825-80277913   c
            816-1016            JAXUCZ010000018.1  80275787-80275987   c
            1017-1101           JAXUCZ010000018.1  80273152-80273236   c
            1102-1262           JAXUCZ010000018.1  80267586-80267746   c
            1263-1427           JAXUCZ010000018.1  80264705-80264869   c
            1428-1569           JAXUCZ010000018.1  80263386-80263527   c
            1570-1717           JAXUCZ010000018.1  80261987-80262134   c
            1718-2853           JAXUCZ010000018.1  80259766-80260901   c
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2853
                     /gene="Cndp1"
                     /note="carnosine dipeptidase 1"
                     /db_xref="GeneID:307212"
                     /db_xref="RGD:1359493"
     exon            1..211
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..413
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    264..266
                     /gene="Cndp1"
                     /note="upstream in-frame stop codon"
     CDS             336..1814
                     /gene="Cndp1"
                     /EC_number="3.4.13.20"
                     /note="CNDP dipeptidase 1; carnosine dipeptidase 1
                     (metallopeptidase M20 family)"
                     /codon_start=1
                     /product="beta-Ala-His dipeptidase"
                     /protein_id="NP_001424269.1"
                     /db_xref="GeneID:307212"
                     /db_xref="RGD:1359493"
                     /translation="MLSPPHSGTLEKLFQYIDLHQDEFVQTLKEWVAIESDSVQPMPR
                     LRQELFRMMALAADKLRNLGARVDSVDLGSQQMPDGQSLPTPPIILAELGNDPKKPSV
                     CFYGHLDVQPAQKEDGWLTDPYTLTEVDGKLYGRGATDNKGPVLAWINAVSTFRALQQ
                     DLPVNVKFILEGMEEAGSVALEELVKREKDNFFSGVDYIVISDNLWLSQKKPALTCGT
                     RGNCYFTVEVKCRDQDFHSGTFGGILNEPMADLVALLGSLVDSSGHILVPGIYDQMAP
                     ITEEEKTMYENIDLDLEEYQKSSRVERFLFDTKEELLTHLWRYPSLSIHGIEGAFDEP
                     GTKTVIPGRVLGKFSIRLVPHMTPSVVETQVTQHLEAVFSKRNSFNKMAVSMVLGLQP
                     WTANINGTQYLAARRAIQTVFGVDPDMIQDGSTIPIAKIFQDITQKSVMMLPLGAVDD
                     GEHSQNEKINRWNYIQGSKLFAAFFLELSKLHSGQQVPSGAF"
     misc_feature    372..1778
                     /gene="Cndp1"
                     /note="M20 cytosolic nonspecific dipeptidases including
                     anserinase and serum carnosinase; Region:
                     M20_dipept_like_CNDP; cd05676"
                     /db_xref="CDD:349925"
     misc_feature    372..1778
                     /gene="Cndp1"
                     /note="M20 cytosolic nonspecific dipeptidases including
                     anserinase and serum carnosinase; Region:
                     M20_dipept_like_CNDP; cd05676"
                     /db_xref="CDD:349925"
     misc_feature    order(654..656,753..755,855..860,942..944,948..950,
                     987..989,1386..1388,1497..1499,1599..1601,1605..1613,
                     1692..1694)
                     /gene="Cndp1"
                     /note="active site"
                     /db_xref="CDD:349925"
     misc_feature    order(654..656,753..755,855..860,942..944,948..950,
                     987..989,1386..1388,1497..1499,1599..1601,1605..1613,
                     1692..1694)
                     /gene="Cndp1"
                     /note="active site"
                     /db_xref="CDD:349925"
     misc_feature    order(666..668,684..686,990..992,996..998,1002..1004,
                     1008..1010,1026..1037,1041..1073,1077..1079,1089..1091,
                     1098..1103,1110..1118,1218..1220,1227..1235,1242..1247,
                     1269..1271,1278..1283,1296..1319,1329..1352,1356..1361,
                     1374..1376,1386..1388,1461..1466,1470..1472,1497..1499,
                     1602..1607,1689..1700)
                     /gene="Cndp1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349925"
     misc_feature    order(666..668,684..686,990..992,996..998,1002..1004,
                     1008..1010,1026..1037,1041..1073,1077..1079,1089..1091,
                     1098..1103,1110..1118,1218..1220,1227..1235,1242..1247,
                     1269..1271,1278..1283,1296..1319,1329..1352,1356..1361,
                     1374..1376,1386..1388,1461..1466,1470..1472,1497..1499,
                     1602..1607,1689..1700)
                     /gene="Cndp1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349925"
     misc_feature    915..917
                     /gene="Cndp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q66HG3.1); phosphorylation site"
     exon            414..563
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..726
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..815
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1016
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1101
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1262
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1427
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1569
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1717
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..2853
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctgccag tctgggatgg atctgggatt aactcacccc ggaaaagcct gagggttttg
       61 ttttcttcct ttgtattttg ttctaaacca atcaccgtga aaagctgggt taataaaaca
      121 cgtttttcca ctgtcataat aaattccttg aagcagaaac agaacagagc agccttctcc
      181 acgcaggaac attaggacgg caggagactt ggcttcatct cccgctgcac tgctgctgcg
      241 ggccaatcat aggcttcatc tcttagtcac tgctgctgtg ggccaatcat aagcttcgtc
      301 tctcctgggc actgctgctg cagctggagc gcggaatgtt atctcctcca cactctggga
      361 cgctggagaa gctcttccag tacatagacc tccaccagga tgagtttgtg cagaccctga
      421 aggaatgggt ggccattgag agtgattctg tgcagcccat gcctcgtctc agacaggagc
      481 tcttccggat gatggcctta gccgcagaca aactccggaa cctgggagct agggtggatt
      541 ctgtagacct gggttctcag cagatgcctg acggtcagag tcttcccacg cctcctatca
      601 tattggctga acttggaaat gatcccaaga agccctccgt atgtttctat gggcacctgg
      661 atgtgcagcc agctcagaag gaggatgggt ggctcacgga cccctacaca ctgacagagg
      721 tggatgggaa actgtatgga cggggagcga cagacaacaa aggccctgtc ttggcttgga
      781 ttaatgccgt gagcaccttc agagctctgc agcaggatct tcccgtgaac gtcaagttca
      841 tcctggaagg gatggaggaa gctggttctg tcgccctgga ggaactcgtc aaaagagaaa
      901 aagacaactt cttctctggt gtggactaca ttgtgatttc agacaacctg tggctcagcc
      961 agaagaagcc tgcactcact tgtggaaccc gggggaactg ctacttcacg gtggaggtaa
     1021 agtgtagaga tcaagatttc cattccggaa cctttggtgg catcctcaac gaaccaatgg
     1081 ctgacctggt tgctcttcta ggtagcctgg tagattcatc aggccacatc ctagttcctg
     1141 gaatctatga tcaaatggcc cctattacag aggaggaaaa gacaatgtat gaaaacattg
     1201 atctggacct agaagaatac cagaagagca gccgggttga aagatttctg tttgatacca
     1261 aggaggagct cctcacgcat ctgtggagat acccgtctct ctccatccat ggcatcgagg
     1321 gtgcatttga tgagcccgga actaaaacag tcattcccgg ccgcgtccta ggaaaatttt
     1381 caatccgtct agtcccacac atgactccgt ctgtggtaga gacacaggtg acgcagcatc
     1441 tggaagcggt gttctcaaaa aggaatagtt tcaacaagat ggctgtttct atggtactag
     1501 gactccagcc gtggactgca aacatcaatg gcactcagta cctcgcagca cgaagagcca
     1561 tccaaacagt gtttggagtc gatcctgaca tgatccagga tgggtcaacc attccaattg
     1621 ctaaaatatt ccaggatatc acccaaaaga gtgtgatgat gctcccgctg ggggctgtgg
     1681 acgatggaga gcactcccag aatgagaaga tcaacaggtg gaactacata caagggtcga
     1741 aattattcgc tgcctttttc ctggagttgt caaagcttca ttcaggacag caggtgcctt
     1801 ccggagcatt ctgacccacc ggcagatctc cccacctcag accccccggc aaagctggag
     1861 gagggaaaat tcaggaaatg tggaaaatga aatgtttgga agcacagatg ctggagagat
     1921 tttaacagtc cctctgtcac ttaactttca caagtctcag ctacctggct ggtcagtccc
     1981 tgaaaccact gtaaggctgg gactgccttc tagtgcaggt gggctgtctc ttcaggaaat
     2041 taggttctca ctttcacttc cattggctca gtcctccagt tcactttcca ggcctgaaga
     2101 gctatggttc ccaatcattg gacctggggg ggtttcagga cctgagtcat cttcacctct
     2161 gtttccttaa taacggaagt ggtggctttc atcactggct agagtgattt tcccatggat
     2221 tcacctttag aagagttact agaacatgtc tcttgttctt gcctcccctt catttatttt
     2281 ctccagactc ttgaacattc tgaagctaaa cgatcagtat tcataccctc acaccgtttg
     2341 gaatccctat gcaaagatga attgttttct ttaattccaa atttcttcag ctttacctgc
     2401 tcagcccctc tgccgcccat cctcccactc cgtcagtaaa gccccttccc tgcaaacatg
     2461 tgcacccgcc attctaccag caacattcac cccaatggaa tttcacgcca ttgaaatttt
     2521 gcctgatgag tttatttgaa ttgcttaaag cttttaataa cgccagcgtt agatggagaa
     2581 ctaatcagcc ctgacatcag caagacattc tcgatttaaa gctctcagct aaatctgcat
     2641 ccactaatca ttttagttaa ctatcttgtt tggctcgatt gggcttggtg gtgtaaacac
     2701 tataaaaagt taattttttt ttcttacaat caagtgtata taaataaact gattcttcta
     2761 agttcattac ttaaatcccg ttaataggaa agaacttgaa ggcttatttt taaatgcttc
     2821 tcttatggtt ccaaataaaa acattccata aca
//
LOCUS       NM_001437257            1010 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17),
            transcript variant 5, mRNA.
ACCESSION   NM_001437257
VERSION     NM_001437257.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1010)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1010)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 1010)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1010)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.2036807.1,
                                           SRR26360194.921237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000012.1  32587831-32587880   c
            51-239              JAXUCZ010000012.1  32586751-32586939   c
            240-379             JAXUCZ010000012.1  32586490-32586629   c
            380-1010            JAXUCZ010000012.1  32584816-32585446   c
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1010
                     /gene="Mrps17"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
     exon            1..50
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     exon            51..239
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    143..145
                     /gene="Mrps17"
                     /note="upstream in-frame stop codon"
     exon            240..379
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..640
                     /gene="Mrps17"
                     /note="28S ribosomal protein S17, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_001424186.1"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
                     /translation="MSIVRSAVHAKWVVGKVIGTAMVKTAKVRATRLVLDPYLLKYFN
                     KRKTYFAHDALQQCSVGDIVLLRALPVPRAKHVKHELAEIIFKVGRVIDPVTGKPCAG
                     TAYLESPLSSEATPPCESREELKSS"
     misc_feature    287..508
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     misc_feature    287..508
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     exon            380..1010
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgcc caggctcctc cggccttggt ccgagttgta ggttttggag aggatcccct
       61 ggaactggtg ctgcaaaggt ttcgagccac cataagggtg ctgaaaactg aacccaggtc
      121 ctctggaaga gcaaccaatg cttagctgct taggcatctg tctctccagc ccagctcatg
      181 ggaggctaat gtagaaggct ctcccagttt aacgcaagcc tgggctacag tggagaaagg
      241 cgctcacaga cacataatgt caatagtccg ttcagccgtc cacgccaaat gggttgtggg
      301 gaaggtgatt ggtacagcaa tggtaaaaac tgctaaagta agagcgacca gacttgtttt
      361 ggatccctac ttactaaagt actttaataa gcggaaaacc tactttgctc atgacgccct
      421 tcagcagtgc agcgtcgggg acatcgtgct cctcagagct ctgcccgtcc cacgagcaaa
      481 gcacgtgaaa cacgaactgg cagagatcat cttcaaagtg ggccgagtta tcgaccccgt
      541 cacaggaaag ccctgtgcag gaaccgccta cctggagagc cccctcagtt cagaagccac
      601 tcccccctgc gaatctcgag aagagctcaa gtcctcctga acctggggaa gagggagcca
      661 gaggatggat gtctgtctgt ttgctcagtg gcttttcata ctgtttctcc tgtgacatta
      721 gaagtattca acagagtaaa gagcttagcg ttccataaag gttcgcatcc tttttcagat
      781 tctctgccct gaagttacct tccgagtact ctgtatgcct aagcgtgctg cgtcattccg
      841 taagctcact gtcctagatc atatatgtat tgttttgttt gccatcactc aaagaaatct
      901 tggactttgc acctttattt taaaagaaga aaaccttttg ataataacag aaaaggctaa
      961 acttagtttc gatagctgaa tttttcaaaa tatatcgtgt gtgtccacaa
//
LOCUS       NM_001437380             813 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 4, mRNA.
ACCESSION   NM_001437380 XM_063275738
VERSION     NM_001437380.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063275738.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1196189.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680446,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000016.1  82528885-82529051   c
            168-248             JAXUCZ010000016.1  82512490-82512570   c
            249-313             JAXUCZ010000016.1  82511368-82511432   c
            314-474             JAXUCZ010000016.1  82508838-82508998   c
            475-813             JAXUCZ010000016.1  82504646-82504984   c
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..813
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..167
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             78..542
                     /gene="Cfap97d2"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 4"
                     /protein_id="NP_001424309.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKRVASAMKTGRRIDGQNNFTWRRKSREQALMKVQKQNQAVPERLRS
                     SEPWYGAQRWREDWTAMATRPCTCRHTWRKGADREAQQGHSLIWMRSLKRKG"
     exon            168..248
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..313
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..474
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..813
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcaaac agctctgcgg gggctgtact gctgtgcctg ctcttccctg aagggaccct
       61 ggagtttgtg atctgagatg catagagtgc cccagctgac caccccgtgg gctagtagag
      121 acctgcagag agcctgggag aaaacctacc agaaccacag gaaaaaggtc cagaacgccc
      181 aaccactcgt ggacacccgc ccaccacaga cttacagcca cctccaccta aagttcaaga
      241 agttgaagag ggtggcctcc gccatgaaaa ccgggagacg gattgatggg caaaataact
      301 tcacatggag aaggaaatcg agagaacagg cattgatgaa agtgcagaaa caaaatcaag
      361 ccgttccaga aagactcaga agctcagagc cctggtatgg agcacagaga tggcgggagg
      421 actggactgc catggccacg cgtccctgca catgcagaca cacctggaga aaaggagctg
      481 atcgtgaagc ccaacaaggc cacagcctca tctggatgcg cagcctgaag cggaaggggt
      541 gagggttcac gacccaacca ccgaaagaag accagggcct ggaagctccg atgaggcctt
      601 cctgtgtctc ccaggggtgg gggtggggat gtggggtgtg caggtctagc atccgagatc
      661 acgctggctc tggggacggc tgtgggagct gtgacgcggc actctgaagc ttcacggtca
      721 cggccgtcgc cagatgacac agcacggctg tttactgtgt ttcttggacc gataaccaaa
      781 aacaaaatat gcagagtgac tctgcgagtt aca
//
LOCUS       NM_001025272            1989 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus PGAM family member 5, mitochondrial
            serine/threonine protein phosphatase (Pgam5), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001025272 XM_222256
VERSION     NM_001025272.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Chen,Y., Huang,J., Zhou,H., Lin,J. and Tao,J.
  TITLE     Pgam5 aggravates hyperglycemia-induced myocardial dysfunction
            through disrupting Phb2-dependent mitochondrial dynamics
  JOURNAL   Int J Med Sci 21 (7), 1194-1203 (2024)
   PUBMED   38818468
  REMARK    GeneRIF: Pgam5 aggravates hyperglycemia-induced myocardial
            dysfunction through disrupting Phb2-dependent mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Zhang,J., Li,X., Zhang,Z., Zhang,J., Ma,L., Wang,S., Guo,X., Li,H.,
            Pan,B. and Niu,Q.
  TITLE     Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells
            necroptosis
  JOURNAL   Ecotoxicol Environ Saf 270, 115860 (2024)
   PUBMED   38142589
  REMARK    GeneRIF: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced
            PC12 cells necroptosis.
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Fu,G., Wang,B., He,B., Feng,M. and Yu,Y.
  TITLE     LPS induces cardiomyocyte necroptosis through the Ripk3/Pgam5
            signaling pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 32-37 (2021)
   PUBMED   32580628
  REMARK    GeneRIF: LPS induces cardiomyocyte necroptosis through the
            Ripk3/Pgam5 signaling pathway.
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Liu,G., Qian,M., Chen,M., Chen,T. and Qin,S.
  TITLE     miR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute
            Lung Injury by Directly Targeting PGAM5
  JOURNAL   Biomed Res Int 2020, 4807254 (2020)
   PUBMED   33681349
  REMARK    GeneRIF: miR-21-5p Suppresses Mitophagy to Alleviate
            Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   Yang,C., Liu,X., Yang,F., Zhang,W., Chen,Z., Yan,D., You,Q. and
            Wu,X.
  TITLE     Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL
            degradation and controls cardiomyocyte apoptosis driven by
            myocardial ischemia/reperfusion injury
  JOURNAL   In Vitro Cell Dev Biol Anim 53 (3), 248-257 (2017)
   PUBMED   27815660
  REMARK    GeneRIF: PGAM5 controls cardiomyocyte apoptosis induced by MIRI
            through regulating Keap1-mediated Bcl-xL degradation, which may
            supply a novel molecular target for acute myocardial infarction
            (AMI) therapy.
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Sekine,S., Yao,A., Hattori,K., Sugawara,S., Naguro,I., Koike,M.,
            Uchiyama,Y., Takeda,K. and Ichijo,H.
  TITLE     The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers
            Resistance Against Metabolic Stress
  JOURNAL   EBioMedicine 5, 82-92 (2016)
   PUBMED   27077115
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1989)
  AUTHORS   Wei,H., Liu,L. and Chen,Q.
  TITLE     Selective removal of mitochondria via mitophagy: distinct pathways
            for different mitochondrial stresses
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt B), 2784-2790 (2015)
   PUBMED   25840011
  REMARK    Review article
REFERENCE   8  (bases 1 to 1989)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   9  (bases 1 to 1989)
  AUTHORS   Wang,Z., Jiang,H., Chen,S., Du,F. and Wang,X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
REFERENCE   10 (bases 1 to 1989)
  AUTHORS   Takeda,K., Komuro,Y., Hayakawa,T., Oguchi,H., Ishida,Y.,
            Murakami,S., Noguchi,T., Kinoshita,H., Sekine,Y., Iemura,S.,
            Natsume,T. and Ichijo,H.
  TITLE     Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic
            activity as a protein serine/threonine phosphatase to activate ASK1
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12301-12305 (2009)
   PUBMED   19590015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001025272.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092607.1, SRR26643288.48362.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000012.1  52069073-52069290
            219-397             JAXUCZ010000012.1  52071781-52071959
            398-523             JAXUCZ010000012.1  52072789-52072914
            524-612             JAXUCZ010000012.1  52072997-52073085
            613-746             JAXUCZ010000012.1  52073180-52073313
            747-1989            JAXUCZ010000012.1  52074889-52076131
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1989
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="PGAM family member 5, mitochondrial
                     serine/threonine protein phosphatase"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
     exon            1..218
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..897
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase PGAM5, mitochondrial;
                     phosphoglycerate mutase family member 5"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 1"
                     /protein_id="NP_001020443.2"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
                     /translation="MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDADTRTTEP
                     LAWTGARPGHGVWDSNWDRREPLSLINLKKRNVESGEDELASRLDHYKAKATRHIFLI
                     RHSQYNVDGSMEKDRTLTPLGREQAELTGIRLASLGLKFNKIVHSSMTRAVETTDIIS
                     KHLPGVCRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADAKQ
                     EEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGD
                     TGFMPPDKITRS"
     misc_feature    49..117
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="propagated from UniProtKB/Swiss-Prot (Q562B5.1);
                     transmembrane region"
     misc_feature    67..888
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; Region: HP; cl11399"
                     /db_xref="CDD:472174"
     misc_feature    67..888
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; Region: HP; cl11399"
                     /db_xref="CDD:472174"
     misc_feature    100..105
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); cleavage site"
     misc_feature    286..288
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); phosphorylation site"
     misc_feature    order(337..342,481..483,715..720)
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     misc_feature    order(337..342,481..483,715..720)
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     misc_feature    373..375
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     misc_feature    457..459
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     misc_feature    598..600
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     exon            219..397
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            398..523
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            524..612
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            613..746
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1989
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcccgccgt ccggtcgtgc ggcttgcggc atggctttcc ggcaggctct tcagctggcg
       61 gcctgtggtc tggcgggtgg ctcggccgct gttctcttct cggcggtagc ggtagggaag
      121 ccgagagctg gcggggatgc agacacgcgc acgacagagc cgctggcctg gaccggagcg
      181 cgccccgggc acggcgtctg ggactccaac tgggacaggc gagagccact gtcactcatt
      241 aacctgaaga aaaggaacgt ggaatctgga gaagatgaac tggcttccag gctggaccac
      301 tataaggcaa aggctacaag acacatattc ctcatccggc attcccagta caatgtggat
      361 ggctcgatgg agaaggaccg caccctgacc ccattaggtc gggaacaggc tgaactcacg
      421 gggatccgac ttgcaagcct gggactgaag tttaataaaa tcgtccattc ctctatgacc
      481 cgtgcagtag agaccacaga catcatcagt aagcacctgc caggtgtctg cagagtcagc
      541 acagacttgc tacgggaagg tgcccccatt gaaccggatc cacctgtgtc tcactggaag
      601 ccagaggctg tgcagtatta tgaagatgga gcccggattg aggctgcctt caggaactac
      661 atccaccgag ctgatgccaa gcaggaggag gacagctacg agatcttcat atgtcacgcc
      721 aatgtcatcc gttatattgt ttgtagggca ctgcagtttc ccccagaagg ttggctccgc
      781 ctgtccctca acaatggtag tatcacccac ctggtgattc gacccaatgg tcgtgttgca
      841 ctcaggaccc ttggggacac agggttcatg cccccagaca agattactcg gtcctgaggc
      901 tgtctgtaag actgcaccct gtcctctgct ggtggcctgc ctacagcctt cccttgtctt
      961 ccacagctgt gctgtggctt cacgttcgtc tccagaagag gatatctcaa gtgtcacatt
     1021 tgggtgctta cttctggctc aggctgaaga aggcaacgta tgagttagat ggcctttttg
     1081 aaagctctct actttactat taccaccagc atagccctag gaggtgcgac aggagccttc
     1141 ctaggcagaa ggcgggcctg tcacgggtac tgtatcacgg gattgtagta gatcaaccga
     1201 acactctatg acctctggaa gacctgtcag gtagtggggt ggtgtttaca ggtggttatt
     1261 tcactgcaat ctagggactt tggttgctta tttatcaaag attttcctca tgtgggttct
     1321 tgctttgaaa accaacttct cagctcaatt aggagattct gtgtctactg catttgaatg
     1381 atggacaaag gggctggctt cctataaggt agataaaagc caagaaagtg gcactgctaa
     1441 aggactgtgg cctgtataag gcaagtaggt gatagttctg taagaggttc cttggaagca
     1501 aagatagccc cactgaccag aagaggtggc atatacttgt aattctagca tctgggaggc
     1561 agaagcagga tcgtgagtct ctagccagcc tgagttatgt taaaagaccc agaaaaatat
     1621 ccctgagtga cggttccatt ttagtttgct actgttaacc ttgaacttgt aggttattta
     1681 gaaatgatgt gtttattcca gatattctga taagaaaaaa atggtttttg tatgtgtggt
     1741 ttttgttttt gtgacagaat cttaactgtt gcccaggctg gcttcaaact tgagaccctt
     1801 ctgagtcttg taattgttgg gattgcaggt atatactacc acacctgtcc gttcgtcccc
     1861 ctatcctcca aaaaacccag tacagtttct atgaaatggt tgtgagcatc ttctgtaatc
     1921 aatgcaatga attggaatat ttgatgtatc tctctgccct ctttggaaat aataaaattt
     1981 tactttgtt
//
LOCUS       NM_001437427            1948 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus polo-like kinase 5 (Plk5), transcript variant 4,
            mRNA.
ACCESSION   NM_001437427 XM_063263418
VERSION     NM_001437427.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063263418.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000007.1  10005661-10005843   c
            184-291             JAXUCZ010000007.1  10004242-10004349   c
            292-421             JAXUCZ010000007.1  10003456-10003585   c
            422-509             JAXUCZ010000007.1  10002630-10002717   c
            510-605             JAXUCZ010000007.1  10002452-10002547   c
            606-804             JAXUCZ010000007.1  10001658-10001856   c
            805-931             JAXUCZ010000007.1  10001445-10001571   c
            932-1008            JAXUCZ010000007.1  10001180-10001256   c
            1009-1081           JAXUCZ010000007.1  10000771-10000843   c
            1082-1159           JAXUCZ010000007.1  10000493-10000570   c
            1160-1316           JAXUCZ010000007.1  9999984-10000140    c
            1317-1446           JAXUCZ010000007.1  9998944-9999073     c
            1447-1557           JAXUCZ010000007.1  9998755-9998865     c
            1558-1948           JAXUCZ010000007.1  9997453-9997843     c
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1948
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polo-like kinase 5"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
     exon            1..183
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1749
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /EC_number="2.7.11.21"
                     /note="isoform 4 is encoded by transcript variant 4;
                     polo-like kinase 5 pseudogene; serine/threonine-protein
                     kinase PLK5; inactive serine/threonine-protein kinase
                     PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5
                     isoform 4"
                     /protein_id="NP_001424356.1"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
                     /translation="MEPRLRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYL
                     HQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSR
                     NGHSAKSDIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIA
                     RLLAPDPDERPSLDHLLQDDFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQL
                     LLTQCRPPCPFTSKEASGPGEESTEPDHMEASNEEGAPLCTESRIHLLTLGTPRTDPA
                     DAKGTLALQLEVATRKLCLCLDAGPVAGQDPPGEQRSVLWAPKWVDYSLKYGFGYQLS
                     DGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGPLRAKLAVLRLFACYM
                     QRRLREEGTAPMTATPASPDFCLLSFTADAQALAMLFSNGTVQVSSKTSPVQLVLSGE
                     GEDFLLTIQEPGGPSMGTSYTLDVLRSHGISLAVRHHLRLGLHLLQSV"
     misc_feature    151..798
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    151..798
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    1189..1452
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    1189..1452
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    order(1207..1218,1423..1425,1429..1443)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     misc_feature    order(1207..1218,1423..1425,1429..1443)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     exon            184..291
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            292..421
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            422..509
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            510..605
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            606..804
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            805..931
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1008
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1081
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1159
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1316
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1446
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1557
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1948
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcggcag cgctgcaggc agcactggct tgcccagttc ccgcgcgcgc gctgcgcacc
       61 caggcccacc ccgcgtcgat ggagccccgg ttgaggcggc ggcgaagccg ccagctagtg
      121 gccaccttcc tgcgtgaccc gggctcaggg cgcgtgtacc ggcgcgggaa gctgatcggc
      181 aagggcgcct tcagccgctg ctacaagctc acggacatgt ccaccagcgc ggtgtttgct
      241 cttaaggtgg tgccgagggg cggagcgggg cggctgcgcc tgcgcgggaa gtccttggct
      301 catgtactga aagtgcggcg gaccctgacg gagcctgaag tgcgctacta ctttcggggc
      361 ctggtcagtg gcctccgcta cctgcaccaa caacgcatcg tgcacaggga cctgaaaccc
      421 agtaatttct tccttaacaa gaacatggaa gttaagatag gtgacctggg gctggctgcc
      481 cgtgtggggc ccgctggccg ctgccacagg gtgctctgtg ggactccgaa cttccaggct
      541 cctgaagtgg tgtcccgaaa tggacactcg gccaagtctg acatctgggc cctggggtgc
      601 attatgtaca cggtgctgac gggcacgccc cccttcgctg ccgcaccctt gtccgagatg
      661 taccaaaaca tccgagacgg tcactacctt gagcccactc agctgtcacc cagcgcccgt
      721 agcctcattg cacgacttct ggcaccggac cctgatgagc ggcccagcct ggaccactta
      781 ctgcaagatg acttttttag tcagggcttt accccagagc ggctgcctcc acattcctgc
      841 cacagcccac ccgtgtttgc cttccccccg ccactgggca ggttgttccg gaaggtgggc
      901 caactcctgc tgacccagtg ccggccgccc tgtcccttta cctcaaaaga ggcctcaggc
      961 ccgggagaag agagtacaga acctgaccac atggaggcca gcaacgagga aggggctcct
     1021 ctctgcactg agagccgaat ccacctcctc actcttggaa cccctcggac tgacccggcc
     1081 gatgcgaagg ggaccttggc cctgcagctg gaggtggcaa ccagaaaact gtgcctctgc
     1141 ttggatgcag gacctgtggc tggacaggac ccccccgggg agcagcgctc tgtcctctgg
     1201 gctcccaagt gggtggatta ttccctcaag tatggcttcg gttaccagct gtcggatggg
     1261 ggcagtggcg tgctgtttcg ggatggctcc cacatggccc tgcgcccccc aggaggccat
     1321 gtctcctacc aacctgacca agggactctg tggatcttcg ccctgaggga cgtccccggc
     1381 ccactccgcg ccaagctggc cgtcctgagg ctctttgcct gctacatgca gcggcgtctg
     1441 cgggaggagg ggacagcacc catgacggcc acacccgcct ctcctgactt ctgtctgctg
     1501 agcttcaccg ctgatgccca agctctggcc atgctcttta gcaatgggac agtgcaggtc
     1561 agttccaaaa cctccccagt ccagctggtg ctgagtgggg aaggcgagga ctttctgctc
     1621 accatccagg agccaggggg acccagcatg ggcacctcct acacgctgga cgtcctgcgg
     1681 agtcacggca tcagccttgc ggtccgccac cacctgcgcc ttggactgca tctgcttcag
     1741 agtgtctaag gagccggacg gagatctggg cggacctctg cgtgatggtg ctggtgtctg
     1801 tttctgtctg cgctcctccg ccacagccag tgtctgtgga gggtggacac attgggacct
     1861 ctgatgggtg ggcgtctttg attatttgac tactcaaggt agactttttt tggattttca
     1921 ttaaagaaaa cagaaccctt taaactgc
//
LOCUS       NM_001011924            2520 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 8, mRNA.
ACCESSION   NM_001011924 XM_214530
VERSION     NM_001011924.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001011924.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081932.1, SRR26643293.77805.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-989             JAXUCZ010000018.1  70152116-70152226
            990-1058            JAXUCZ010000018.1  70152308-70152376
            1059-1358           JAXUCZ010000018.1  70153375-70153674
            1359-1496           JAXUCZ010000018.1  70153761-70153898
            1497-1628           JAXUCZ010000018.1  70154230-70154361
            1629-1690           JAXUCZ010000018.1  70154449-70154510
            1691-2520           JAXUCZ010000018.1  70158915-70159744
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2520
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1763
                     /gene="Mbd1"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 8"
                     /protein_id="NP_001011924.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTEL
                     HISDQTPTAPAEFVYDCVEEDELKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQL
                     SSPLKAPLAVVTTPPGPVQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAA
                     STENPAQETQGSAPGWVVALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLD
                     PPPVKREPPGPEEDGEENKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWL
                     PRLHKLLAVNENEYFTELQLKEEIL"
     misc_feature    168..377
                     /gene="Mbd1"
                     /note="Methyl-CpG binding domain; Region: MBD; smart00391"
                     /db_xref="CDD:128673"
     misc_feature    168..377
                     /gene="Mbd1"
                     /note="Methyl-CpG binding domain; Region: MBD; smart00391"
                     /db_xref="CDD:128673"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..989
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1058
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1358
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1496
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1628
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2520
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaaggg taaatatgat catagtaaga
      901 gaggcccgag ggtagcttct cgacgtcact cccgagcccc gccacttcct ccacacgctg
      961 cgtcacagca tccagagccc acagaactgc acatcagcga ccaaacgccc acagcacctg
     1021 ctgagttcgt ctatgactgt gtagaggagg acgagctaaa gcggctgctg cccagtattg
     1081 ggccagggtc tgaggaggaa gcaagattgc ttccacatca tacccaccaa aagaggtctg
     1141 cttctactcg acagctgcaa ctgagctctc ccttaaaggc tcctttggct gtggtcacaa
     1201 ccccaccggg ccctgtccaa gattcaggga agcggcaagc aggtagtggc tttgtactgc
     1261 cccaacctga cacagacctt gtgtatttac aagagggtac cagcagtctc atgcaggtgc
     1321 ctggccctgc tgcagcttcc acagaaaacc cagcacagga gacccagggc tctgccccag
     1381 gttgggttgt ggccttgccc caggtgaagc aagagaaggc ggatgcccca gaggagtgga
     1441 cagcagtcac aaccttcctg acttcttcca cggtgcagcc tggcttcctt agcaaggcgt
     1501 caggcctgga ccctccacct gtgaaacgag agccccctgg ccctgaggag gatggagaag
     1561 agaacaaaga agatgatgtc tctgaatcag ctccagcaga agagatagga gggattggca
     1621 ccccagtgat cacggagatt ttcagcctgg gtggaacccg cctccgggat gcagaagcct
     1681 ggttgccaag gctacataaa ctgttagcag taaatgaaaa tgagtatttt actgagctgc
     1741 agttgaaaga agaaatattg taggagagaa aagcaattat tattaagaga agaaagacat
     1801 tcttttgtgg ctgaaaagct gaacctggaa ttcaggaaat ggaatctaaa tctagagatg
     1861 taccatgtag aaaatctgaa gtgggtgggt tacaaataat taagcacact aatttgaaga
     1921 aaaccatcct taaacatgtg tacacatgga ttgcacttag tatctgtcag tgactggcct
     1981 tattactgtc ctcccccttc ctcttcttgt tcccccatcc ctcttaacag gggcaccaca
     2041 gtagcagtca gtttgctctt aagcagtgta actccgtttt atggttacta ggagctacaa
     2101 ctctggtttc catgtatgct gaagaccgtc tagtttcctg gactgcattg ccagttttgc
     2161 ctgggatccc gattctcaag aattgagtat ctgaacttct gatccgaagc tcattcctcc
     2221 agtcagacaa ctgccctgct agtatttctg atctgccctc ttcctgtgtt agcccaaagt
     2281 gtgggcccca ttttctgttc agtgcagtag gaagattttg ttcacagatc ttactggttg
     2341 tgtagctcga caaggcactt tggcttcctg agccttagtt gacttcactg caaactaaag
     2401 ccaataccct cagttccttc aaccctgtaa gaattttgtc aacctcaaag gttgtttctg
     2461 gaaatacttt gcaaattgta aaaaaaaaaa aaaaaaaaaa aaaaagagag agaaacaata
//
LOCUS       NM_001437393            1487 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 68 (Ccdc68),
            transcript variant 2, mRNA.
ACCESSION   NM_001437393 XM_063277189
VERSION     NM_001437393.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277189.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1000149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000018.1  65817263-65817401
            140-264             JAXUCZ010000018.1  65830766-65830890
            265-351             JAXUCZ010000018.1  65832026-65832112
            352-486             JAXUCZ010000018.1  65837996-65838130
            487-612             JAXUCZ010000018.1  65840508-65840633
            613-741             JAXUCZ010000018.1  65841071-65841199
            742-810             JAXUCZ010000018.1  65852339-65852407
            811-894             JAXUCZ010000018.1  65853741-65853824
            895-971             JAXUCZ010000018.1  65856970-65857046
            972-1487            JAXUCZ010000018.1  65859014-65859529
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1487
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="coiled-coil domain containing 68"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
     exon            1..139
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="upstream in-frame stop codon"
     exon            140..264
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1029
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="isoform 2 is encoded by transcript variant 2; CTCL
                     tumor antigen se57-1; coiled-coil domain-containing
                     protein 68"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 68 isoform
                     2"
                     /protein_id="NP_001424322.1"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
                     /translation="MTTVTVTMEVPSGGKTEDRSIFSGPSSAQIIEETEYVRKIRTTL
                     EKIRNRMFKEEDGRGNARHKVDAEQSGNVQNGLDSTTDPTRLDLLLESMRRKDQQLLE
                     MNKENEVLQIKLEASREAGAAALRNAAQRLFDNYQTQSEDLEKKHKDSKHVLQVNKLE
                     KEQTLKQRAKNLSQLSEKLGEKHEQIVGLENRVQRMENEQICHLQFVIHSQHQNLRNI
                     IQEMEGLKNTLKEQDKKIENLKEKVTVLEAQNEELKTKVAHWTESPRTSVSKAVSTSE
                     LKTEGASPYLMLIRLRK"
     misc_feature    <400..960
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <400..960
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            265..351
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            352..486
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            487..612
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            613..741
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            742..810
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            811..894
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            895..971
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1487
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgggaca ctggactctg ccctgggcgc gcctatctga gcacttaggt gctctcagtc
       61 gccaaacttc agcagttaag gacccgacgg tgggctctct gccagatcgc tggaactgga
      121 gcaggcggag gccttcaaga attcaccatg acaactgtca cggtgaccat ggaagttcct
      181 tctgggggta agacagaaga ccgctccatc ttcagtggac cgtcgtcagc tcagattatt
      241 gaagaaactg agtatgtgag aaagattcga actaccctgg aaaagatccg gaatcgcatg
      301 tttaaggagg aagacggccg aggcaatgca aggcacaaag tagatgcaga gcaatctgga
      361 aatgttcaga atggcttgga ttctacaaca gaccccacca ggttggattt gctcttggaa
      421 agcatgagaa gaaaagatca gcagctccta gaaatgaaca aagaaaacga agtgttgcaa
      481 atcaagctgg aagcttcccg agaagcagga gcggcagctt tgagaaatgc ggctcagaga
      541 ttatttgaca actaccaaac gcagtctgaa gacctggaga aaaagcataa ggacagtaaa
      601 catgtacttc aggtcaacaa actcgagaaa gagcagacgt taaagcaacg tgccaaaaat
      661 ctgagtcaac tttcagaaaa actgggagaa aaacatgagc aaatcgtagg actggaaaac
      721 cgtgtccaga ggatggaaaa tgagcagatc tgtcatctgc agttcgtgat ccactcccag
      781 caccagaacc tgcgcaacat catccaggag atggaaggac taaaaaatac tttaaaggaa
      841 caagataaaa aaattgaaaa tttgaaagaa aaggtcaccg tgctcgaagc ccagaatgaa
      901 gaactaaaaa ccaaggtggc acactggacg gaatctccta ggacatcagt atctaaggcc
      961 gtctctacaa gtgagttgaa gactgaaggt gcttctccct atttgatgtt gattcggcta
     1021 cgaaaatgag ctggctggct gcagttctga cagagaagga cttctacaga ttttatttat
     1081 tccttgaaat acagtttcag ctcccaagtt aaagtgacat catgtcttat ctaaatgtaa
     1141 cttagtatac atcaataacg gcatagaaag gtgatattgc aggcaattca acaaatgtct
     1201 cctggagaga agaaaccttt ttctttttaa accaaaatgt aacttaaaag gccaagggac
     1261 taggatcttt cccacatgga agatgaattc tgctttaaac ctaaaatatt aaaatttgaa
     1321 tctatctctc ttcaaacatt ttacaaagag gactcttata aggttgtcag atttgacctt
     1381 tgatagtggt tcttatgtgt ataaataaag ggaagtatgt aaatatatat taatgaatga
     1441 tgtaatttaa tttggcattt aggtaataaa tatcttacca tgccaca
//
LOCUS       NM_001437354            1929 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 2, mRNA.
ACCESSION   NM_001437354
VERSION     NM_001437354.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85237.1,
                                           SRR26360181.3026278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000012.1  40085187-40085357
            172-341             JAXUCZ010000012.1  40093729-40093898
            342-531             JAXUCZ010000012.1  40096705-40096894
            532-651             JAXUCZ010000012.1  40098953-40099072
            652-833             JAXUCZ010000012.1  40100973-40101154
            834-1015            JAXUCZ010000012.1  40102786-40102967
            1016-1236           JAXUCZ010000012.1  40106323-40106543
            1237-1311           JAXUCZ010000012.1  40109132-40109206
            1312-1504           JAXUCZ010000012.1  40110908-40111100
            1505-1708           JAXUCZ010000012.1  40112332-40112535
            1709-1929           JAXUCZ010000012.1  40113600-40113820
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1929
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..171
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     misc_feature    118..120
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDQLLISMDSTVSQPLQM"
     misc_feature    139..141
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDSTVSQPLQM"
     misc_feature    169..171
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     M"
     CDS             172..1851
                     /gene="Ccdc63"
                     /note="isoform 1 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_001424283.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            172..341
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            342..531
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            532..651
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            652..833
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1015
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1236
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1311
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1504
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1708
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1929
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttttgtt ttctctggtt gacgtgtggg ccatgatcct ccacatagtt ccaagaaggc
       61 tgccatagct ccagacatca aagcctcgta caagcagaat cccaacagga aaggaagatg
      121 gaccagttgc tgatttccat ggactcaacc gtatcacagc cgctgcaaat gatgaagaaa
      181 cacaggagga aggtctctga accccttccg gaactttccg agaaggccaa agagcagttg
      241 gctgaggcag agctacggaa actaaggcag cagttccgga agatggtaga cagccgaaag
      301 tcttccaatt tccgcaacca gcggatgatc gccagccagt acaaggagat agagaatttg
      361 aaagcggagc aggcagagac caccttgctt ctgagcctcg tgaagtcgcc aaagaaccta
      421 gacctcaacc agaaaaattt cacggagctg cgcttcctgc tgcagaccaa gggggactac
      481 gaggctctga tctcctccat gaaggtgctg ctgggagaac tggatgacaa gattgttcag
      541 atggagagaa agatcacaaa ccagagacag atcttcttga agacacaaga ggccaacaat
      601 ccccggaagc tgcagaaaca gatccacatt ctggagacca gactgaacct ggtcactgtc
      661 cactttgaca cgatgttgac ctccaatgcc cagctccgga aggatattga ggatcttctc
      721 tttgagaagg ctgcctacga ccatgtctac cagcagcttc agcggcgtct gcagacacag
      781 aagaagacca tgaatgtggc catcgagcag tctacccagg cctatgagca gagagtggaa
      841 gccatggctc ggatggctgc catgaaggac cgccagcaaa aagacatctc tcagtacaac
      901 ctggagatcc gagagctcga acgcctgtat gaccacgaga acaaactcaa gtcctttctg
      961 cttgtcaagc tcaatgaccg cacggaattc gaggaccagg ccaagaagca ggaagctgtc
     1021 aaaattaaga agcatgggaa aaagaggaag ggtgagagct ttgagagcta cgaggtggcc
     1081 catctccgac tgctaaagct ggctgagaac ggggacctga accagctcac tgaggacttc
     1141 ctggccaagg aggagaagaa ttttgctcgc ttcacctatg tcaccgagct caacaatgac
     1201 atggagacca tgcacaagag gacccagcgg atccaggatg acatcatcaa cctgcggtca
     1261 cagcagcagt cctcccatga gggcacccgg aacatcctga aacagatgga ggagaaactg
     1321 aggaagacca ccgaggacac ggacatttat gagaacaggt acagggaaat gagcaagacc
     1381 ctggagtacc tcaagaactc agtggagaag ctgtttaaga agatcaactg caatgccacg
     1441 gagatcctgg ggaaactggg tgagactggg aagatcacgg acagcaacct tcagcagtac
     1501 ttcgctatca tagaaaagaa gacaaatgac ctcctgcttc tggagtcttt ccggcgcctg
     1561 caggaggcag aggggcccga tgttgatgtc ccacaaccct ttgtcaaccc cttctggggg
     1621 ggctctgccc tcctcaagcc cccagagccc ttaagggttg tgccgcctgt gtttggggca
     1681 gactccttca gtgacaaagt tgaagaggtt cctcacagag ctctgtcctg ggtgcagtgg
     1741 aataccctct ggaccacagt agcctccggc agctggtctt ggagaactac cttcagaagg
     1801 aacgaggaaa agaaccacag gagacactgt tggagaaggg ggacgagata agggtcaaga
     1861 agaaggtgat aagctgaacc ccgtgggtgg ctgtattcca caccgagaaa ataaatgttt
     1921 tcttgccga
//
LOCUS       NM_001108976             815 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus LSM10, U7 small nuclear RNA associated (Lsm10),
            transcript variant 2, mRNA.
ACCESSION   NM_001108976 XM_001056695 XM_345581
VERSION     NM_001108976.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 815)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   2  (bases 1 to 815)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   3  (bases 1 to 815)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
REFERENCE   4  (bases 1 to 815)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001108976.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.20782.1,
                                           SRR26360176.858815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000005.1  143658592-143658645
            55-815              JAXUCZ010000005.1  143659631-143660391
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..815
                     /gene="Lsm10"
                     /note="LSM10, U7 small nuclear RNA associated"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
     exon            1..54
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     exon            55..815
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Lsm10"
                     /note="upstream in-frame stop codon"
     CDS             79..447
                     /gene="Lsm10"
                     /note="U7 snRNP-specific Sm-like protein LSM10"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm10"
                     /protein_id="NP_001102446.1"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
                     /translation="MALSHSVKERTISENSLIILLQGLQGQITTVDLRDESVARGRID
                     NVDAFMNIRLANVTYTDRWGHQVELDDLFVTGRNVRYVHIPDGVNITATIEQQLQIIH
                     RVRNFGGKGQGRREFPSKRP"
     misc_feature    100..333
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    100..333
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    order(163..183,187..225,229..243)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(163..183,187..225,229..243)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(217..219,223..225,301..303)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    order(217..219,223..225,301..303)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    289..324
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    289..324
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
ORIGIN      
        1 ctcttccctt ggcgcactgg ctgcggactc ttcttcccaa accccttacg cgcgtgagca
       61 gccaaccaat gtggaaaaat ggcactgagc cactctgtga aggagcgaac catctctgag
      121 aacagcctga tcatcctgtt gcaaggcctc cagggacaaa taaccactgt ggaccttcga
      181 gatgagagtg tggcccgagg acgcatcgac aacgttgatg ctttcatgaa catccgtctg
      241 gccaatgtca cctacaccga ccgctggggg catcaggttg agttggatga ccttttcgtg
      301 acaggtcgta atgtccgata tgtccatatc ccagacggtg tgaacatcac tgccacaatc
      361 gagcagcagc tacagatcat ccaccgtgtg cgcaactttg gtggcaaggg tcaaggtcgt
      421 cgagagttcc cctccaaaag gccatgagac tgtgtcctca ttcaaattcc agcaccacct
      481 cagggacctc cagtgttctg agccaactcc cgtccatcct tccccaccaa tgacctggtg
      541 tcttatagac acatcacagc tgcctttcat agggttccac ttttcagaca caccttggga
      601 cccagaattc cttctgctgg tggccttggg gtaggtgaca atccctcttt ttgatcattt
      661 gtatctggaa tctccattca ctgattgacc ccatccatca aggagttgtt aactctgcca
      721 gtgaggatta cttgagagtg tttggagtga atcacctcta acatcccatt tctcttgtca
      781 tttgtttctt ttctcataaa accaaactcc tggga
//
LOCUS       NM_001437362            1919 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 11, mRNA.
ACCESSION   NM_001437362
VERSION     NM_001437362.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1919)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1526770.1,
                                           SRR26360181.226334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000012.1  40085187-40085357
            172-341             JAXUCZ010000012.1  40093729-40093898
            342-531             JAXUCZ010000012.1  40096705-40096894
            532-651             JAXUCZ010000012.1  40098953-40099072
            652-833             JAXUCZ010000012.1  40100973-40101154
            834-1015            JAXUCZ010000012.1  40102786-40102967
            1016-1236           JAXUCZ010000012.1  40106323-40106543
            1237-1311           JAXUCZ010000012.1  40109132-40109206
            1312-1504           JAXUCZ010000012.1  40110908-40111100
            1505-1708           JAXUCZ010000012.1  40112332-40112535
            1709-1919           JAXUCZ010000012.1  40113610-40113820
FEATURES             Location/Qualifiers
     source          1..1919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1919
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..171
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     misc_feature    118..120
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDQLLISMDSTVSQPLQM"
     misc_feature    139..141
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDSTVSQPLQM"
     misc_feature    169..171
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     M"
     CDS             172..1752
                     /gene="Ccdc63"
                     /note="isoform 3 is encoded by transcript variant 11;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     3"
                     /protein_id="NP_001424291.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEELCPGCSGIPSGPQ"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            172..341
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            342..531
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            532..651
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            652..833
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1015
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1236
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1311
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1504
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1708
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1919
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttttgtt ttctctggtt gacgtgtggg ccatgatcct ccacatagtt ccaagaaggc
       61 tgccatagct ccagacatca aagcctcgta caagcagaat cccaacagga aaggaagatg
      121 gaccagttgc tgatttccat ggactcaacc gtatcacagc cgctgcaaat gatgaagaaa
      181 cacaggagga aggtctctga accccttccg gaactttccg agaaggccaa agagcagttg
      241 gctgaggcag agctacggaa actaaggcag cagttccgga agatggtaga cagccgaaag
      301 tcttccaatt tccgcaacca gcggatgatc gccagccagt acaaggagat agagaatttg
      361 aaagcggagc aggcagagac caccttgctt ctgagcctcg tgaagtcgcc aaagaaccta
      421 gacctcaacc agaaaaattt cacggagctg cgcttcctgc tgcagaccaa gggggactac
      481 gaggctctga tctcctccat gaaggtgctg ctgggagaac tggatgacaa gattgttcag
      541 atggagagaa agatcacaaa ccagagacag atcttcttga agacacaaga ggccaacaat
      601 ccccggaagc tgcagaaaca gatccacatt ctggagacca gactgaacct ggtcactgtc
      661 cactttgaca cgatgttgac ctccaatgcc cagctccgga aggatattga ggatcttctc
      721 tttgagaagg ctgcctacga ccatgtctac cagcagcttc agcggcgtct gcagacacag
      781 aagaagacca tgaatgtggc catcgagcag tctacccagg cctatgagca gagagtggaa
      841 gccatggctc ggatggctgc catgaaggac cgccagcaaa aagacatctc tcagtacaac
      901 ctggagatcc gagagctcga acgcctgtat gaccacgaga acaaactcaa gtcctttctg
      961 cttgtcaagc tcaatgaccg cacggaattc gaggaccagg ccaagaagca ggaagctgtc
     1021 aaaattaaga agcatgggaa aaagaggaag ggtgagagct ttgagagcta cgaggtggcc
     1081 catctccgac tgctaaagct ggctgagaac ggggacctga accagctcac tgaggacttc
     1141 ctggccaagg aggagaagaa ttttgctcgc ttcacctatg tcaccgagct caacaatgac
     1201 atggagacca tgcacaagag gacccagcgg atccaggatg acatcatcaa cctgcggtca
     1261 cagcagcagt cctcccatga gggcacccgg aacatcctga aacagatgga ggagaaactg
     1321 aggaagacca ccgaggacac ggacatttat gagaacaggt acagggaaat gagcaagacc
     1381 ctggagtacc tcaagaactc agtggagaag ctgtttaaga agatcaactg caatgccacg
     1441 gagatcctgg ggaaactggg tgagactggg aagatcacgg acagcaacct tcagcagtac
     1501 ttcgctatca tagaaaagaa gacaaatgac ctcctgcttc tggagtcttt ccggcgcctg
     1561 caggaggcag aggggcccga tgttgatgtc ccacaaccct ttgtcaaccc cttctggggg
     1621 ggctctgccc tcctcaagcc cccagagccc ttaagggttg tgccgcctgt gtttggggca
     1681 gactccttca gtgacaaagt tgaagaggag ctctgtcctg ggtgcagtgg aataccctct
     1741 ggaccacagt agcctccggc agctggtctt ggagaactac cttcagaagg aacgaggaaa
     1801 agaaccacag gagacactgt tggagaaggg ggacgagata agggtcaaga agaaggtgat
     1861 aagctgaacc ccgtgggtgg ctgtattcca caccgagaaa ataaatgttt tcttgccga
//
LOCUS       NM_001437278            5043 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 6, mRNA.
ACCESSION   NM_001437278 XM_063288142
VERSION     NM_001437278.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5043)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 5043)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 5043)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5043)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5043)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 5043)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 5043)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 5043)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 5043)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 5043)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063288142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21986.1,
                                           SRR26360181.2275346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000005.1  165405713-165405877 c
            166-284             JAXUCZ010000005.1  165403843-165403961 c
            285-457             JAXUCZ010000005.1  165392825-165392997 c
            458-686             JAXUCZ010000005.1  165389591-165389819 c
            687-916             JAXUCZ010000005.1  165389275-165389504 c
            917-1078            JAXUCZ010000005.1  165388373-165388534 c
            1079-1228           JAXUCZ010000005.1  165388101-165388250 c
            1229-1318           JAXUCZ010000005.1  165387693-165387782 c
            1319-1540           JAXUCZ010000005.1  165386476-165386697 c
            1541-1637           JAXUCZ010000005.1  165385787-165385883 c
            1638-1768           JAXUCZ010000005.1  165385559-165385689 c
            1769-1819           JAXUCZ010000005.1  165384765-165384815 c
            1820-1987           JAXUCZ010000005.1  165384521-165384688 c
            1988-2109           JAXUCZ010000005.1  165384309-165384430 c
            2110-2253           JAXUCZ010000005.1  165383996-165384139 c
            2254-2353           JAXUCZ010000005.1  165383697-165383796 c
            2354-2532           JAXUCZ010000005.1  165383289-165383467 c
            2533-2645           JAXUCZ010000005.1  165383088-165383200 c
            2646-2724           JAXUCZ010000005.1  165382877-165382955 c
            2725-2892           JAXUCZ010000005.1  165382365-165382532 c
            2893-3016           JAXUCZ010000005.1  165381666-165381789 c
            3017-3162           JAXUCZ010000005.1  165381296-165381441 c
            3163-3295           JAXUCZ010000005.1  165380825-165380957 c
            3296-5043           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..5043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5043
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..165
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            166..284
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            285..457
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             317..3433
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform c is encoded by transcript variant 6;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform c"
                     /protein_id="NP_001424207.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEVSTKDMPLALMACALRKK
                     ATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSI
                     LAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMK
                     LVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVV
                     EKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPA
                     GTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQLQLREI
                     LERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWP
                     ELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELT
                     KFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEA
                     LSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCV
                     EQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMDFLWKQE
                     GLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSK
                     NPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFK
                     TKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLF
                     ALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAH
                     NVSKDNRQ"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    860..1141
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    860..1141
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1238..1741
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1238..1741
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1808..2350
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1808..2350
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2324..3424
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2324..3424
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2552..2554,2558..2566,2570..2572,2576..2578,
                     2627..2629,2633..2635,2642..2644,2735..2737,2771..2782,
                     2795..2797,2804..2806,2990..2992,2996..2998,3026..3031)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2552..2554,2558..2566,2570..2572,2576..2578,
                     2627..2629,2633..2635,2642..2644,2735..2737,2771..2782,
                     2795..2797,2804..2806,2990..2992,2996..2998,3026..3031)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2756..2761,3062..3067,3071..3073,3077..3079,
                     3275..3277,3284..3286)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2756..2761,3062..3067,3071..3073,3077..3079,
                     3275..3277,3284..3286)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2897..2899
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2897..2899
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2966..2992
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2966..2992
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    3029..3103
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    3029..3103
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            458..686
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            687..916
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1078
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1228
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1318
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1540
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1637
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1768
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1819
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1987
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2109
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2253
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2353
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2532
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2645
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2724
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2892
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3016
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3162
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3295
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..5043
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcactcac cgccacctcg agcggcgggg cctgccctca ggccctgccg gctgcactcc
       61 gccgcccgga ggctggcgcc ctccggtcac ttcgggaccc tcccgccgtg tcccctgggt
      121 aactgtctcc agggagacgg agcccgcccc tgccaccaac accggacaca taaggagctg
      181 agagccaggc agaagtggga tgaagctccc tgatggcaaa gcacctgtaa tctcccaggc
      241 acaggggcct tggctggtgg tccttctcgg cccatcccaa acaggagaac aggcctcaga
      301 gaagtaacac agcaggatgc cccctggggt agactgcccc atggagttct ggaccaaaga
      361 ggagagccag agcgtggccg ttgacttctt gctgcccaca ggagtctact tgaacttccc
      421 tgtgtcccgc aatgccaacc tcagcaccat caagcaggtg ctgtggcatc gtgcacagta
      481 tgagccgttc ttccacatgc tcagtgaccc cgaggcttat gtgttcacct gtgtgaacca
      541 gacagcggag cagcaggagt tggaggatga gcagcggagg ctgtgtgaca tccagccctt
      601 cctgcccgtg ctgcgcctgg tggcccgaga gggggaccgc gtgaagaagc tcatcaactc
      661 acagatcagc ctcctcatcg gcaaaggtct ccatgagttt gattccctgc gggacccgga
      721 agtaaacgac ttccgcacta agatgcgcca gttttgcgaa gaggccgcgg ctcaccgcca
      781 gcagctgggc tgggtggaat ggctgcagta tagcttcccc ctgcagctgg agccctcagc
      841 cagaggttgg cgggctggct tattgcatgt cagcaaccga cccctgctgg tcaatgtgaa
      901 gttcgagggc agtgaggtat ccaccaagga catgcccctc gcactgatgg cctgtgccct
      961 ccgaaaaaag gccaccgtgt tccggcagcc tctggtggag aggcctgagg agtatgccct
     1021 gcaggtgaac gggaggcacg agtacctcta cggcagctac cccctctgcc actttcagta
     1081 catctgtagc tgcctgcaca gcggactgac tccccatctg accatggtcc actcctcctc
     1141 catcctcgcc atgagggatg agcagagcaa ccctgccccc caggtgcaga agccacgagt
     1201 caaacctccc ccgatccctg ccaagaagcc ctcctctgtg tccctgtggt ccctggaaca
     1261 gccattctgc attgagctga ttgagggccg caaggtgaat gcggatgaaa ggatgaagct
     1321 ggttgtgcag gccgggctct tccacggcaa tgagatgctg tgcaagactg tgtcgagctc
     1381 agaggtgaat gtgtgctcag agcccgtgtg gaagcagcga ctagaattcg acatcagcat
     1441 ctgtgacctc ccccgaatgg cccggctctg ctttgcactc tatgctgtcg tggagaaggc
     1501 taagaaggcg cgctccacaa agaagaagtc caagaaggcg gactgtccca tcgcttgggc
     1561 caacctcatg ctattcgact acaaagatca gctcaagacg ggcgaacggt gcctctacat
     1621 gtggccctct gtcccagatg agaaagggga actgatgaat cctgcgggta cagtacgtgg
     1681 taaccccaac acagagagtg ccgctgccct ggtcatctac ctacctgagg tggctcccca
     1741 ccctgtgtac ttccctgctc tggagaagat cctggagctg gggcgtcacg gggagcgtgg
     1801 gcgcatcaca gaggaggagc agctgcagct gcgggagatc ctggagcggc ggggatctgg
     1861 ggaactgtac gaacatgaga aggacctggt gtggaagatg cgtcacgaag tccaggagca
     1921 tttcccagag gcgctggccc gcctgctact ggtcaccaag tggaataaac atgaggatgt
     1981 ggcccagatg ctctatttgc tgtgctcctg gcccgagctt cctgtgctga gcgccctgga
     2041 gcttctggac tttagttttc ctgactgcta cgtgggttcc ttcgccatca agtccctacg
     2101 gaagctgacg gatgacgagc ttttccagta ccttctgcag ctggtacaag tactcaaata
     2161 tgagtcctac ctggactgcg agttgaccaa attcttgttg ggccgagccc tggctaaccg
     2221 caagatcggg cacttcctgt tctggcacct ccgctctgag atgcatgtac cgtccgtggc
     2281 cctgcgtttt ggcctcatca tggaagccta ctgcagaggc agcacccacc acatgaaggt
     2341 gctgatgaag cagggggagg cactgagcaa gcttaaggcc ctgaatgact ttgtgaaggc
     2401 gagctcgcag aagaccacca agccccagac caaggagatg atgcatatgt gtatgcgcca
     2461 ggagacttac atggaggcgc tgtcccacct gcagtctccc ctcgacccca gcaccctgct
     2521 ggaggaagtc tgtgtggagc agtgcacctt catggactcc aaaatgaagc cattgtggat
     2581 catgtacagc agcgagaagg caggcggtgc cggcagcgtg ggcatcatct ttaagaacgg
     2641 ggatgacctc cgccaggaca tgctgactct gcagatgatc cagctcatgg acttcctatg
     2701 gaagcaggag ggcctggacc tgaggatgac cccctatggc tgcctcccca ccggagatcg
     2761 cacaggcctc attgaggtgg tcctccactc ggacaccatc gccaacatcc agctgaataa
     2821 aagcaacatg gcagccacgg ctgcgttcaa caaggacgct ctgctcaact ggctcaagtc
     2881 taagaaccct ggggaggctc tggatcgggc cattgaggaa ttcaccctct cctgtgctgg
     2941 ctactgtgtg gccacatatg tgctgggcat cggtgaccgg cacagcgata acatcatgat
     3001 cagagagagt gggcagcttt tccacattga ctttggccac tttctgggga acttcaagac
     3061 caagttcggg atcaaccggg agcgtgtccc cttcattctc acctacgact ttgtccacgt
     3121 gatccagcag gggaagacta acaacagtga gaaatttgaa aggttccgag gctactgtga
     3181 acgagcctac accatcctgc ggcgtcacgg gctgcttttc cttcatctct tcgccctcat
     3241 gcgcgcagca ggtctgcctg agcttagctg ctccaaagac atccagtatc tcaaggactc
     3301 tctggcacta gggaagacgg aggaagaagc actaaagcac ttccgggtga agttcaatga
     3361 agctctccgg gagagctgga aaaccaaagt caactggctg gcacacaatg tgtccaagga
     3421 taacaggcag taagaggcgc ccccctgggc gtcacattcc cctgggcgtc acatggcagt
     3481 tccctggttc cctccgggct ctcagccata gaggtaaact gtcagtcctg gagaccaggc
     3541 atgctcagtg gtcatcaaag gggccccaga cctgaactgt ccctcacaga gaagaaccac
     3601 acaactgctt cttgtttaca ctggttattt atttatgact cgaaatgttt aaggaacaga
     3661 atagccataa atggaagtgc atttttgtgc aggggagggg tgctgtcctc gtgacccccc
     3721 ctccctcagc actgtaaaca gcaccttgag gatcgtaccc ctagtcttcc aacctgtggg
     3781 tcttggcccc ccaaaggcag ttttgggggc caccttccca ggctcccagc cggctgccta
     3841 gaacaagcct ggcagtcacc tggtgcctcc cacgcagaca ggacacctca atcctcagct
     3901 cagctcacct ccgccacctt catgtggccc accctcggcg acctccatct accaagcctc
     3961 cggcagctcc tgaggaagcc aggagcttcc ctctagactc aggcacactt gctctgcact
     4021 gctgaagtga caacctcttg ggtacggaaa caccctcacc ttttatttgc gggtaagaac
     4081 atgattatgt aaactctgta tagaatagcc ggggtaaagg acctggcttc cactacagat
     4141 agctgtgttc tgggcctcaa aacactagag attggtgccc gatttagtgc ggtgtggtcg
     4201 tgaatccaga caaagggcaa gcctgaacgg agtcctcttc gcaatttgtg tgagaaccgc
     4261 acacaaaggc agctttctgg aaggacagga ctgatgtctc ccagagctgc cattctcaga
     4321 aggcagctgg ggtcccgggt tctgaagtgt gcgcgaggag gaggaccaag tttagtagtc
     4381 tgggcgactg gagcatctcc agaaatgcag ggtctccacc ccctcccagg tatccaaacc
     4441 tactttgggc tgtagagcca gtcacctggc tttttagaga gcccagctca gtggtgcaca
     4501 tgcataaaac gtgccatccc gagcccaccg tgatgcatca gctgccgcct caggacctgg
     4561 ctctcccggt aacatcctga gacttgcaga accatcaccg ccgtcttgct ggcagcccag
     4621 aacatggctg ctcaaggaag ccaggtgtcc gctctttcac gatgatgaac tgagggtcca
     4681 gcagtggttg gtgcctccag ggcacttgct gaacccttag tctgccccaa ctctgaaata
     4741 ggaagtgtgc gtgcgtgtgc gtgcgtgtgc gcgtgtgtgc cgtgttattt attgaaaaga
     4801 gtctaggtgc tccctggtgt ggctgcagat tctgcagagg ctcagccttt ctgggttggg
     4861 tatgtggtct gtgtacctgg ctggaaaagt attttctatt tttttttttt aaaagttgtt
     4921 ctacgtttct gtagggggga aggtagattt cctctcactg atgtgggctg agatcagtct
     4981 gtgcaaccct gacacgtccg gtaaagacag gtgaaaagaa ataaaaatct ttttatgttc
     5041 tta
//
LOCUS       NM_001108971            4234 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus myogenesis regulating glycosidase (Myorg),
            transcript variant 2, mRNA.
ACCESSION   NM_001108971 XM_001068567 XM_345524
VERSION     NM_001108971.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Datta,K., Guan,T. and Gerace,L.
  TITLE     NET37, a nuclear envelope transmembrane protein with glycosidase
            homology, is involved in myoblast differentiation
  JOURNAL   J Biol Chem 284 (43), 29666-29676 (2009)
   PUBMED   19706595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001108971.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.19021.1,
                                           SRR26643296.14972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000005.1  61460228-61460304   c
            78-122              JAXUCZ010000005.1  61457208-61457252   c
            123-4234            JAXUCZ010000005.1  61452956-61457067   c
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4234
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="myogenesis regulating glycosidase"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
     exon            1..77
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     exon            78..122
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     exon            123..4234
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    176..178
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="upstream in-frame stop codon"
     CDS             185..2335
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /codon_start=1
                     /product="myogenesis-regulating glycosidase"
                     /protein_id="NP_001102441.1"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
                     /translation="MPQNLQEKSQVYPRHRLGSHAGPKSLEVIPGATMYTFLPDNFSP
                     AKPKPTKELRPLLCSVVLGLLLVLAAVVAWCYYSASLRKAERLRAELLDLNRGGFSIR
                     NQKGEQVFRLAFRSGALDLDSCSRDGALLGCSRTADGRPLHFFIQTVRPKDTVMCYRV
                     RWEEAAPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDA
                     AFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSMRLQARYHHTSYKPPAGRTAAP
                     ELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPASEAFRDPIWSTWALYGRSVDQNKVLQ
                     FAQQIRQHRFNSSHLEIDDMYTPAYGDFDFDESKFPNATDLFHRLRDAGFRVTLWVHP
                     FVNYNSSRFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTRPEAREWFQGHLRRL
                     RSRYNVASFKFDAGEVSYLPPDFSTYKPLSDPSVWSRRYTEMALPFFSLAEVRVGYQS
                     QNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMIGGNAVPERTAGRP
                     DGPGPERELYVRWLEVAAFMPAMQFSIPPWQYDAEVVAIAHKFAALRASLVAPLLLEL
                     AGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAG
                     KWRSYKGELFDKTPVLLTDYPVDLDEVAYFTWAS"
     misc_feature    1121..2236
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    1121..2236
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    order(1238..1243,1562..1564,1568..1573,1685..1687,
                     1739..1741,1991..1993,1997..1999)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
     misc_feature    order(1238..1243,1562..1564,1568..1573,1685..1687,
                     1739..1741,1991..1993,1997..1999)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
ORIGIN      
        1 ggctgatcaa ctcctgctag cgtggagaga ggatcagctg gaggaccctt cttcccttct
       61 ttgtggcggt cactgagagt tctcaccgat ttggcaagcc gtggggcctg agagaaacaa
      121 ggacatcagc acgacagttt cagatgggcc ctggtgtggt ggttcctttc ttagctagga
      181 actgatgccc cagaaccttc aggagaagag ccaggtctac cccagacatc gacttggtag
      241 ccacgcaggc cctaaaagtc tcgaagttat cccaggagca accatgtaca ctttcctgcc
      301 tgacaatttt tcacctgcca aacccaagcc cactaaagag ctgaggcctc tgctatgctc
      361 cgtggtactg ggactgctgc tggtgctggc cgcagttgtg gcctggtgct actatagcgc
      421 ctccttacgc aaagctgaac gcctgcgcgc agagctgctg gacctgaacc gtggcggctt
      481 ctccatccgt aaccagaagg gtgagcaagt cttccgcttg gccttccgtt cgggtgcgct
      541 ggatcttgac tcctgtagcc gggacggtgc cctgcttggc tgctcccgaa cggccgatgg
      601 gcgcccgttg cacttcttta tccagactgt acgacccaag gacactgtaa tgtgctaccg
      661 cgtgcgctgg gaggaagctg caccagggcg tgctgtagag cacgcgatgt ttctgggaga
      721 tgctgcagcg cactggtatg gtggcgcaga gatgaggacg caacactggc ccatccgcct
      781 agatggccag caagagccgc agccatttgt cacgagcgac gtctactctt ctgacgccgc
      841 attcgggggc atccttgagc gctactggct atcttcccgc gcggccgcca tcaaagtcaa
      901 tgattcagtg cccttccacc tgggctggaa cagcaccgag cgttcgatga gattgcaggc
      961 acgctaccac cacacatctt acaagccacc agccggccgg actgcagcgc cagagctcag
     1021 ctaccgcgtg tgcgtgggct cagatgtcac ctccatccac aagtacatgg ttcgacgtta
     1081 cttcaacaaa ccgtccaggg taccagcgtc agaggccttc cgagacccca tttggtccac
     1141 gtgggctcta tatgggcgct ctgtggacca gaacaaggtg ctgcaattcg cccagcagat
     1201 ccgccagcac cgcttcaaca gcagccatct ggaaatcgat gacatgtaca cgccggccta
     1261 tggtgacttt gatttcgacg agagcaagtt ccccaacgcc actgacctgt tccaccgcct
     1321 gcgagatgct ggcttccgcg tcacactttg ggtgcatccg tttgtcaact ataactcgtc
     1381 gcgtttcggc gaaggtgtgg agcgcgagct gttcgtgcgg gagcccacgg gccgcctgcc
     1441 cgcgctcgtg cgctggtgga acggcattgg cgcggtgctg gacttcacgc gcccagaggc
     1501 ccgagagtgg ttccagggac acctacggcg cctgcgctcg cgctacaacg tggcctcctt
     1561 taagttcgac gcgggtgaag tcagctacct gcccccggac ttcagcacct acaagcctct
     1621 gtctgacccc agtgtgtgga gcaggcggta caccgagatg gcgctgccct tcttctcgct
     1681 agccgaagtc cgcgtggggt accagtcaca gaacatctcc tgcttcttcc gtctagtgga
     1741 ccgcgactcg gtatggggct acgacctggg gctgcgctct ctcatccctg cggtgctcac
     1801 cgtcagtatg ctgggctatc cgttcatctt acctgatatg ataggtggca acgcggtgcc
     1861 ggagcgcaca gcgggccgcc cagatgggcc ggggccagag cgcgaactct acgtgcgctg
     1921 gctggaggtg gccgccttca tgcctgccat gcagttttca atccctcctt ggcagtatga
     1981 cgcagaagtg gtagccatcg cacataaatt cgctgctctg cgcgcctccc tcgtggcgcc
     2041 actgctgctg gagcttgctg gtgaggtcac cgacacgggc gaccccatcg tgcgccccct
     2101 gtggtggatc gcacccgggg atgaaacggc tcaccgcatt gactcacagt tcctcatcgg
     2161 ggacacgctg ttggtggcac cggtactgga acctggtaag caagagcgcg atgtctacct
     2221 gcctgccggc aaatggcgaa gttacaaggg tgagcttttt gacaagacgc ctgtgctgct
     2281 cacggattac cctgtcgacc tggatgaggt cgcctatttc acctgggctt cctgacccag
     2341 ctcagaacct aggaatccca cagccctaac cccagccttc atacaaactt ttaatcctct
     2401 accacgcgcg aacggtgaac cctcaggaag accccacctc tataccatct aggaagtggg
     2461 caccgacttt aaagtgctcc agccaacagc tgtagatgag acctgggagg ggaggtattg
     2521 aaacaacccc tgcaccagcg cacaatccta agagtcccgg ttccttgacc attcgctcca
     2581 gtctgcagaa agcctctccc ttgggttgga gggcagagaa ctgagaggac aaagatctgt
     2641 tctttgtgtt acacagggtc tggttttaaa agcacagaaa gaaacctctc ctcccaccct
     2701 ggtctttgta gccatccttg tcctctgaaa tgaggaacca atcctcttta aaagttccca
     2761 aatagttttc tgccatattt agaaagtgta cctttaacct ggtgttggtg ggatatgcct
     2821 ttaataccag cactcaggaa gcagagagac aggtggatct ccgagatcaa ggccagcatg
     2881 gtctacagat cgagttccag gaagccagcg ctacgcagag aaactctatc tccaaaaaac
     2941 tgaaggaagg aaggaaagaa gaaaggaagg aaggaagaaa ggaaggaaga agagaaagtc
     3001 taccttcttg atgacagcag ctaagccatg agctcccagc acacacctga acagtgactg
     3061 acctgctctc actcgatctg gggaagaaag atacacagat gtttggtttg gccagctgac
     3121 caggaagcaa aaggcctctt cccagtccat aggagaattg aactgaacta atgttctctg
     3181 tctgtgagaa agactcctaa catgcgttaa catatttgta tgtattcata cccagacctg
     3241 ggccagatgt gcctagtaga tagacttgca gggtcatgca ggccggactc gttgccttaa
     3301 ttcaagaacc tgtgtctatg tgtatgtaca catacttctg tcagggcagt ggggagggag
     3361 agagggagag aggcgcccac catgggtctc tgaaatattc ctgaggctag ataagcctag
     3421 agggaggata cggaggcagc ctcagggctt tgattatgat ctaagcccca ttttaggtag
     3481 actccctagg atactgccaa acccagttta agagtttaaa actggagaac tgggctgagg
     3541 aactgactca gaagacaagc ctgactacct gagttcagcc taactcctgc tgtaaaagga
     3601 gagaacggac aatagggtaa gccctttaag attacccagc tgcctccctg cacacacgct
     3661 ctgagtgtag cccgaacggg aaaaccatgt tctatgctgg cagagatgtg cttggcacac
     3721 gaatgacatt acacgctgat aacctgccag cacacgtatg gggaagggct ttcatctcag
     3781 taattctctt gttctaagaa gatcaactcc agctaccgtg aggtgagttt ttcctgattt
     3841 gccagagaag gtggggaatg aagtggggct cagcttccct ctcagagcct gtgcccgaat
     3901 cattcgtttt ctctgggtga aaggtcctgg tgagagcttc agggctcccc agacgcccat
     3961 ctccatgcca attcttttgt ttcttttcct tggcaatgct gaagctagaa cccagggccc
     4021 caagcatact aagtaagcat tcttcctcag ctctatcctc ggtcttcagc cagccgggtg
     4081 accttgaata agctgctgcc taccccactg agcctcagtg ttttctgtgt aagggtgatg
     4141 taatgcctac ctctaaggtc actttaataa taagcacaga catatggaaa gtgcctgaca
     4201 ccaagtaggt gctcaataaa agatagctat tgta
//
LOCUS       NM_001437276            4957 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 4, mRNA.
ACCESSION   NM_001437276 XM_039110499
VERSION     NM_001437276.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4957)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 4957)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 4957)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4957)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4957)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 4957)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 4957)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 4957)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 4957)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 4957)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039110499.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1213213.1,
                                           SRR26643298.30339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  165425848-165425899 c
            53-171              JAXUCZ010000005.1  165403843-165403961 c
            172-344             JAXUCZ010000005.1  165392825-165392997 c
            345-573             JAXUCZ010000005.1  165389591-165389819 c
            574-803             JAXUCZ010000005.1  165389275-165389504 c
            804-983             JAXUCZ010000005.1  165388373-165388552 c
            984-1133            JAXUCZ010000005.1  165388101-165388250 c
            1134-1223           JAXUCZ010000005.1  165387693-165387782 c
            1224-1445           JAXUCZ010000005.1  165386476-165386697 c
            1446-1542           JAXUCZ010000005.1  165385787-165385883 c
            1543-1673           JAXUCZ010000005.1  165385559-165385689 c
            1674-1724           JAXUCZ010000005.1  165384765-165384815 c
            1725-1892           JAXUCZ010000005.1  165384521-165384688 c
            1893-2023           JAXUCZ010000005.1  165384309-165384439 c
            2024-2167           JAXUCZ010000005.1  165383996-165384139 c
            2168-2267           JAXUCZ010000005.1  165383697-165383796 c
            2268-2446           JAXUCZ010000005.1  165383289-165383467 c
            2447-2559           JAXUCZ010000005.1  165383088-165383200 c
            2560-2638           JAXUCZ010000005.1  165382877-165382955 c
            2639-2806           JAXUCZ010000005.1  165382365-165382532 c
            2807-2930           JAXUCZ010000005.1  165381666-165381789 c
            2931-3076           JAXUCZ010000005.1  165381296-165381441 c
            3077-3209           JAXUCZ010000005.1  165380825-165380957 c
            3210-4957           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..4957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4957
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..52
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            53..171
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            172..344
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             204..3347
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform b is encoded by transcript variant 4;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform b"
                     /protein_id="NP_001424205.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQ
                     LQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQLSQ
                     MLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKY
                     ESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHM
                     KVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDP
                     STLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQ
                     LMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKD
                     ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHID
                     FGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRR
                     HGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW
                     KTKVNWLAHNVSKDNRQ"
     misc_feature    303..524
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    303..524
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    747..1046
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    747..1046
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1143..1646
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1143..1646
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1713..2264
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1713..2264
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2238..3338
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2238..3338
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2466..2468,2472..2480,2484..2486,2490..2492,
                     2541..2543,2547..2549,2556..2558,2649..2651,2685..2696,
                     2709..2711,2718..2720,2904..2906,2910..2912,2940..2945)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2466..2468,2472..2480,2484..2486,2490..2492,
                     2541..2543,2547..2549,2556..2558,2649..2651,2685..2696,
                     2709..2711,2718..2720,2904..2906,2910..2912,2940..2945)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2670..2675,2976..2981,2985..2987,2991..2993,
                     3189..3191,3198..3200)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2670..2675,2976..2981,2985..2987,2991..2993,
                     3189..3191,3198..3200)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2811..2813
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2811..2813
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2880..2906
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2880..2906
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2943..3017
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    2943..3017
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            345..573
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            574..803
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            804..983
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1133
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1223
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1445
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1542
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1673
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1724
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1892
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2023
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2167
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2267
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2446
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2559
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2638
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2806
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2930
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3076
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3209
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..4957
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctcct tgcctcgggg ctgccagctc cgcgggcgca gccgctggac cgacacataa
       61 ggagctgaga gccaggcaga agtgggatga agctccctga tggcaaagca cctgtaatct
      121 cccaggcaca ggggccttgg ctggtggtcc ttctcggccc atcccaaaca ggagaacagg
      181 cctcagagaa gtaacacagc aggatgcccc ctggggtaga ctgccccatg gagttctgga
      241 ccaaagagga gagccagagc gtggccgttg acttcttgct gcccacagga gtctacttga
      301 acttccctgt gtcccgcaat gccaacctca gcaccatcaa gcaggtgctg tggcatcgtg
      361 cacagtatga gccgttcttc cacatgctca gtgaccccga ggcttatgtg ttcacctgtg
      421 tgaaccagac agcggagcag caggagttgg aggatgagca gcggaggctg tgtgacatcc
      481 agcccttcct gcccgtgctg cgcctggtgg cccgagaggg ggaccgcgtg aagaagctca
      541 tcaactcaca gatcagcctc ctcatcggca aaggtctcca tgagtttgat tccctgcggg
      601 acccggaagt aaacgacttc cgcactaaga tgcgccagtt ttgcgaagag gccgcggctc
      661 accgccagca gctgggctgg gtggaatggc tgcagtatag cttccccctg cagctggagc
      721 cctcagccag aggttggcgg gctggcttat tgcatgtcag caaccgaccc ctgctggtca
      781 atgtgaagtt cgagggcagt gaggagagct tcaccttcca ggtatccacc aaggacatgc
      841 ccctcgcact gatggcctgt gccctccgaa aaaaggccac cgtgttccgg cagcctctgg
      901 tggagaggcc tgaggagtat gccctgcagg tgaacgggag gcacgagtac ctctacggca
      961 gctaccccct ctgccacttt cagtacatct gtagctgcct gcacagcgga ctgactcccc
     1021 atctgaccat ggtccactcc tcctccatcc tcgccatgag ggatgagcag agcaaccctg
     1081 ccccccaggt gcagaagcca cgagtcaaac ctcccccgat ccctgccaag aagccctcct
     1141 ctgtgtccct gtggtccctg gaacagccat tctgcattga gctgattgag ggccgcaagg
     1201 tgaatgcgga tgaaaggatg aagctggttg tgcaggccgg gctcttccac ggcaatgaga
     1261 tgctgtgcaa gactgtgtcg agctcagagg tgaatgtgtg ctcagagccc gtgtggaagc
     1321 agcgactaga attcgacatc agcatctgtg acctcccccg aatggcccgg ctctgctttg
     1381 cactctatgc tgtcgtggag aaggctaaga aggcgcgctc cacaaagaag aagtccaaga
     1441 aggcggactg tcccatcgct tgggccaacc tcatgctatt cgactacaaa gatcagctca
     1501 agacgggcga acggtgcctc tacatgtggc cctctgtccc agatgagaaa ggggaactga
     1561 tgaatcctgc gggtacagta cgtggtaacc ccaacacaga gagtgccgct gccctggtca
     1621 tctacctacc tgaggtggct ccccaccctg tgtacttccc tgctctggag aagatcctgg
     1681 agctggggcg tcacggggag cgtgggcgca tcacagagga ggagcagctg cagctgcggg
     1741 agatcctgga gcggcgggga tctggggaac tgtacgaaca tgagaaggac ctggtgtgga
     1801 agatgcgtca cgaagtccag gagcatttcc cagaggcgct ggcccgcctg ctactggtca
     1861 ccaagtggaa taaacatgag gatgtggccc agctgtccca gatgctctat ttgctgtgct
     1921 cctggcccga gcttcctgtg ctgagcgccc tggagcttct ggactttagt tttcctgact
     1981 gctacgtggg ttccttcgcc atcaagtccc tacggaagct gacggatgac gagcttttcc
     2041 agtaccttct gcagctggta caagtactca aatatgagtc ctacctggac tgcgagttga
     2101 ccaaattctt gttgggccga gccctggcta accgcaagat cgggcacttc ctgttctggc
     2161 acctccgctc tgagatgcat gtaccgtccg tggccctgcg ttttggcctc atcatggaag
     2221 cctactgcag aggcagcacc caccacatga aggtgctgat gaagcagggg gaggcactga
     2281 gcaagcttaa ggccctgaat gactttgtga aggcgagctc gcagaagacc accaagcccc
     2341 agaccaagga gatgatgcat atgtgtatgc gccaggagac ttacatggag gcgctgtccc
     2401 acctgcagtc tcccctcgac cccagcaccc tgctggagga agtctgtgtg gagcagtgca
     2461 ccttcatgga ctccaaaatg aagccattgt ggatcatgta cagcagcgag aaggcaggcg
     2521 gtgccggcag cgtgggcatc atctttaaga acggggatga cctccgccag gacatgctga
     2581 ctctgcagat gatccagctc atggacttcc tatggaagca ggagggcctg gacctgagga
     2641 tgacccccta tggctgcctc cccaccggag atcgcacagg cctcattgag gtggtcctcc
     2701 actcggacac catcgccaac atccagctga ataaaagcaa catggcagcc acggctgcgt
     2761 tcaacaagga cgctctgctc aactggctca agtctaagaa ccctggggag gctctggatc
     2821 gggccattga ggaattcacc ctctcctgtg ctggctactg tgtggccaca tatgtgctgg
     2881 gcatcggtga ccggcacagc gataacatca tgatcagaga gagtgggcag cttttccaca
     2941 ttgactttgg ccactttctg gggaacttca agaccaagtt cgggatcaac cgggagcgtg
     3001 tccccttcat tctcacctac gactttgtcc acgtgatcca gcaggggaag actaacaaca
     3061 gtgagaaatt tgaaaggttc cgaggctact gtgaacgagc ctacaccatc ctgcggcgtc
     3121 acgggctgct tttccttcat ctcttcgccc tcatgcgcgc agcaggtctg cctgagctta
     3181 gctgctccaa agacatccag tatctcaagg actctctggc actagggaag acggaggaag
     3241 aagcactaaa gcacttccgg gtgaagttca atgaagctct ccgggagagc tggaaaacca
     3301 aagtcaactg gctggcacac aatgtgtcca aggataacag gcagtaagag gcgcccccct
     3361 gggcgtcaca ttcccctggg cgtcacatgg cagttccctg gttccctccg ggctctcagc
     3421 catagaggta aactgtcagt cctggagacc aggcatgctc agtggtcatc aaaggggccc
     3481 cagacctgaa ctgtccctca cagagaagaa ccacacaact gcttcttgtt tacactggtt
     3541 atttatttat gactcgaaat gtttaaggaa cagaatagcc ataaatggaa gtgcattttt
     3601 gtgcagggga ggggtgctgt cctcgtgacc ccccctccct cagcactgta aacagcacct
     3661 tgaggatcgt acccctagtc ttccaacctg tgggtcttgg ccccccaaag gcagttttgg
     3721 gggccacctt cccaggctcc cagccggctg cctagaacaa gcctggcagt cacctggtgc
     3781 ctcccacgca gacaggacac ctcaatcctc agctcagctc acctccgcca ccttcatgtg
     3841 gcccaccctc ggcgacctcc atctaccaag cctccggcag ctcctgagga agccaggagc
     3901 ttccctctag actcaggcac acttgctctg cactgctgaa gtgacaacct cttgggtacg
     3961 gaaacaccct caccttttat ttgcgggtaa gaacatgatt atgtaaactc tgtatagaat
     4021 agccggggta aaggacctgg cttccactac agatagctgt gttctgggcc tcaaaacact
     4081 agagattggt gcccgattta gtgcggtgtg gtcgtgaatc cagacaaagg gcaagcctga
     4141 acggagtcct cttcgcaatt tgtgtgagaa ccgcacacaa aggcagcttt ctggaaggac
     4201 aggactgatg tctcccagag ctgccattct cagaaggcag ctggggtccc gggttctgaa
     4261 gtgtgcgcga ggaggaggac caagtttagt agtctgggcg actggagcat ctccagaaat
     4321 gcagggtctc caccccctcc caggtatcca aacctacttt gggctgtaga gccagtcacc
     4381 tggcttttta gagagcccag ctcagtggtg cacatgcata aaacgtgcca tcccgagccc
     4441 accgtgatgc atcagctgcc gcctcaggac ctggctctcc cggtaacatc ctgagacttg
     4501 cagaaccatc accgccgtct tgctggcagc ccagaacatg gctgctcaag gaagccaggt
     4561 gtccgctctt tcacgatgat gaactgaggg tccagcagtg gttggtgcct ccagggcact
     4621 tgctgaaccc ttagtctgcc ccaactctga aataggaagt gtgcgtgcgt gtgcgtgcgt
     4681 gtgcgcgtgt gtgccgtgtt atttattgaa aagagtctag gtgctccctg gtgtggctgc
     4741 agattctgca gaggctcagc ctttctgggt tgggtatgtg gtctgtgtac ctggctggaa
     4801 aagtattttc tatttttttt ttttaaaagt tgttctacgt ttctgtaggg gggaaggtag
     4861 atttcctctc actgatgtgg gctgagatca gtctgtgcaa ccctgacacg tccggtaaag
     4921 acaggtgaaa agaaataaaa atctttttat gttctta
//
LOCUS       NM_001437218            2839 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            3, mRNA.
ACCESSION   NM_001437218
VERSION     NM_001437218.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2839)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2839)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2839)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2839)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2839)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2839)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2839)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2839)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2839)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2839)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.34968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000012.1  24761299-24761362   c
            65-118              JAXUCZ010000012.1  24760247-24760300   c
            119-365             JAXUCZ010000012.1  24759745-24759991   c
            366-543             JAXUCZ010000012.1  24759477-24759654   c
            544-684             JAXUCZ010000012.1  24756632-24756772   c
            685-796             JAXUCZ010000012.1  24756440-24756551   c
            797-919             JAXUCZ010000012.1  24756223-24756345   c
            920-1036            JAXUCZ010000012.1  24754191-24754307   c
            1037-1176           JAXUCZ010000012.1  24753946-24754085   c
            1177-1340           JAXUCZ010000012.1  24752946-24753109   c
            1341-1460           JAXUCZ010000012.1  24751630-24751749   c
            1461-1543           JAXUCZ010000012.1  24749484-24749566   c
            1544-1607           JAXUCZ010000012.1  24749332-24749395   c
            1608-1675           JAXUCZ010000012.1  24749165-24749232   c
            1676-1752           JAXUCZ010000012.1  24749003-24749079   c
            1753-1837           JAXUCZ010000012.1  24748839-24748923   c
            1838-2065           JAXUCZ010000012.1  24748522-24748749   c
            2066-2206           JAXUCZ010000012.1  24748072-24748212   c
            2207-2839           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2839
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..64
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    59..61
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="upstream in-frame stop codon"
     exon            65..118
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2482
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424147.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    152..163
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    158..217
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    329..391
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    500..>661
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    500..>661
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    701..1273
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    701..1273
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    788..790
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(977..979,1019..1030,1034..1036,1046..1057,
                     1064..1066,1070..1078)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(977..979,1019..1030,1034..1036,1046..1057,
                     1064..1066,1070..1078)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1049..1051,1067..1069)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1049..1051,1067..1069)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1064..1066,1073..1075)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1064..1066,1073..1075)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1076..1078,1082..1084,1094..1099)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1076..1078,1082..1084,1094..1099)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1085..1087
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1295..1996
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1295..1996
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1316..1318,1322..1324,1331..1333,1337..1342,
                     1346..1348,1478..1480,1484..1486,1535..1537,1544..1570)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1316..1318,1322..1324,1331..1333,1337..1342,
                     1346..1348,1478..1480,1484..1486,1535..1537,1544..1570)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1688..1690
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2075..2449
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2075..2449
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            119..365
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..543
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..684
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..796
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..919
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1036
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1176
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1340
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1460
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1543
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1607
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1675
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1752
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1837
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2065
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2206
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2839
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acagggttca ggagggggca caagcatgga acaacgttgg ggtctacttc ggaaagtgca
      121 acagtggtcc ccaagaccct ctcagaccat ctacagacgt gtggaaggcc ctcaactgga
      181 gaacctagag gaggaagata gggaggaagg ggaggagctt cctgcccagt tctgccccat
      241 ggaactcaaa ggccctgagc gcttaggctc ctgtcctggg aggtccattc ccataccctg
      301 ggctgcagca ggtcgaaagg ctgctcccta tctggtcctg accaccctgc taatcttcac
      361 tggggccttc ctcctgggct acgtggcctt tcgagggtcc tgccaggcat gtggggactc
      421 tgtgttggtg gttggtgaag atgtcaactc tgaggactcc agccggggca cgttgtactg
      481 gagtgacctc caggacatgt ttctccggtt ccttggggag ggacgcatgg aggacaccat
      541 caggctgacc agcctccggg aacgcgtggc cggctcagcc agaatggcca ccctggtcca
      601 agacatcctc gataagctct cgcgccagaa gctggaccac gtgtggactg acacgcacta
      661 tgtgggactt cagttcccgg acccggctca ccctaacacc ctgcactggg tgggtgcaga
      721 cgggagcgtc caagagcagc taccgctgga ggatccggaa gtctactgtc cctacagcgc
      781 cacgggcaac gccacgggca agcttgtgta cgcccactac gggcggcggg aggacctgca
      841 ggacctgaaa gccaaggacg tggagctggc cggcagcctc ctgctagtgc gtgctgggat
      901 tacaagcttc gcccagaagg tagccattgc ccaggacttt ggggcccacg gagtgctgat
      961 ataccctgac ccagcggact tctcccaaga cccccacaag ccaggcctgt ctagtgacag
     1021 ggctgtgtat ggacatgtgc acctgggaac tggggaccct tacacgcctg gcttcccgtc
     1081 cttcaatcaa acccagttcc ctccagtaga atcatcgggg cttcccaaca tccctgccca
     1141 gcccatcagt gccgacgttg ctgatcgctt gctcaggaaa ctcacaggtc ccgtggctcc
     1201 tcaggaatgg aagggtcgcc tctcagactc tccgtatcgc ctgggacctg ggccaggctt
     1261 acgccttgtg gtcaacaacc acagaacctc tactcccatc agtaacatct ttgcgtgcat
     1321 cgagggcttc gcagagccag atcactatgt cgttatcggg gcccagaggg atgcctgggg
     1381 cccaggagca gccaagtctg cagtggggac tgccatcctc ctggagctgg ttcggacctt
     1441 ttcctccatg gtcagcagtg gctttagacc tcgaagaagt cttttgttca tcagctggga
     1501 cggaggtgac tttggcagcg tgggagccac ggagtggttg gagggctacc tcagcgtgct
     1561 acacctcaaa gctgtcgtgt atgtgagcct ggacaactcc gtgttgggag acggcaaatt
     1621 ccatgctaag accagccccc ttctcgtcag cctcattgag aatatcctga agcaggtgga
     1681 ttcccctaac cacagtggac agacactcta cgatcaagtg gcattcaccc acccaagctg
     1741 ggatgctgaa gtgatccagc ccctgcccat ggacagcagc gcatattcct tcacagcttt
     1801 tgcgggcgtc ccagctgtgg agttctcctt catggaggac gatagggtgt acccattcct
     1861 gcacacgaag gaggacacgt atgagaatct gcacaagatg ctgcgaggtc gcctgcccgc
     1921 cgtggtccta gcagtggctc agctcgctgg tcagctcctc atccgactga gccacgatca
     1981 cctactgccg ctggacttcg gccgctacgg agacgtggtc ctcaggcaca tcggcaacct
     2041 taatgagttc tctggggacc tcaaggcgcg cgggctgacc ctgcagtggg tgtactctgc
     2101 aaggggggac tatatccggg cggcggagaa gctgcggaag gagatttaca gctcggagca
     2161 gagcgatgag cgtctgatgc gcatgtacaa cgtgcgcatc atgagggtgg agttctactt
     2221 cctgtcccag tacgtgtcgc cggccgactc cccattccgc cacattttcc taggccaagg
     2281 cgaccacact ttgggtgccc tggtggaaca cctacggatg ctgcgctccg atggctcagg
     2341 agctgcctct tctgggttga gcccaggtct gggcttccag gagagtcgct tccggcgaca
     2401 gctggcgctg ctcacgtgga cgctacaggg ggcagccaac gcactcagtg gcgacgtttg
     2461 gaacatcgac aataactttt gaggccagaa gtcctccatg ggccccacgt gattctcctt
     2521 tctccctatt tgagtggtgc aggcaacgga ggtgcctgag agcaacctat cctcattaac
     2581 aaccttggtc ctgcaacgcc agtgagacat attttctcag tgtgactgtt ataccactgt
     2641 ttatccagaa agcggttttc ttcccatcac tggcctctct gccttcagga gcatagttcc
     2701 ccatatctag aaaccatcta gacactggga tccagctctc ttagcgggtg agatggatag
     2761 cgtcattttc ttatgacaca caagtggtat gtgggtggcc caagggggat tagatgtcaa
     2821 taaaccattt acctggtaa
//
LOCUS       NM_001437376            2649 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 6, mRNA.
ACCESSION   NM_001437376 XM_006254913
VERSION     NM_001437376.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 2649)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 2649)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 2649)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 2649)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 2649)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 2649)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 2649)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 2649)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254913.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77807.1,
                                           SRR26643287.35257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1487           JAXUCZ010000018.1  70153375-70153674
            1488-1625           JAXUCZ010000018.1  70153761-70153898
            1626-1757           JAXUCZ010000018.1  70154230-70154361
            1758-1819           JAXUCZ010000018.1  70154449-70154510
            1820-2649           JAXUCZ010000018.1  70158915-70159744
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2649
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1892
                     /gene="Mbd1"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 6"
                     /protein_id="NP_001424305.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPP
                     GPVQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPG
                     WVVALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDG
                     EENKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNENEYF
                     TELQLKEEIL"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    <1032..1808
                     /gene="Mbd1"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <1032..1808
                     /gene="Mbd1"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1487
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1625
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1757
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1819
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2649
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctaaag cggctgctgc
     1201 ccagtattgg gccagggtct gaggaggaag caagattgct tccacatcat acccaccaaa
     1261 agaggtctgc ttctactcga cagctgcaac tgagctctcc cttaaaggct cctttggctg
     1321 tggtcacaac cccaccgggc cctgtccaag attcagggaa gcggcaagca ggtagtggct
     1381 ttgtactgcc ccaacctgac acagaccttg tgtatttaca agagggtacc agcagtctca
     1441 tgcaggtgcc tggccctgct gcagcttcca cagaaaaccc agcacaggag acccagggct
     1501 ctgccccagg ttgggttgtg gccttgcccc aggtgaagca agagaaggcg gatgccccag
     1561 aggagtggac agcagtcaca accttcctga cttcttccac ggtgcagcct ggcttcctta
     1621 gcaaggcgtc aggcctggac cctccacctg tgaaacgaga gccccctggc cctgaggagg
     1681 atggagaaga gaacaaagaa gatgatgtct ctgaatcagc tccagcagaa gagataggag
     1741 ggattggcac cccagtgatc acggagattt tcagcctggg tggaacccgc ctccgggatg
     1801 cagaagcctg gttgccaagg ctacataaac tgttagcagt aaatgaaaat gagtatttta
     1861 ctgagctgca gttgaaagaa gaaatattgt aggagagaaa agcaattatt attaagagaa
     1921 gaaagacatt cttttgtggc tgaaaagctg aacctggaat tcaggaaatg gaatctaaat
     1981 ctagagatgt accatgtaga aaatctgaag tgggtgggtt acaaataatt aagcacacta
     2041 atttgaagaa aaccatcctt aaacatgtgt acacatggat tgcacttagt atctgtcagt
     2101 gactggcctt attactgtcc tcccccttcc tcttcttgtt cccccatccc tcttaacagg
     2161 ggcaccacag tagcagtcag tttgctctta agcagtgtaa ctccgtttta tggttactag
     2221 gagctacaac tctggtttcc atgtatgctg aagaccgtct agtttcctgg actgcattgc
     2281 cagttttgcc tgggatcccg attctcaaga attgagtatc tgaacttctg atccgaagct
     2341 cattcctcca gtcagacaac tgccctgcta gtatttctga tctgccctct tcctgtgtta
     2401 gcccaaagtg tgggccccat tttctgttca gtgcagtagg aagattttgt tcacagatct
     2461 tactggttgt gtagctcgac aaggcacttt ggcttcctga gccttagttg acttcactgc
     2521 aaactaaagc caataccctc agttccttca accctgtaag aattttgtca acctcaaagg
     2581 ttgtttctgg aaatactttg caaattgtaa aaaaaaaaaa aaaaaaaaaa aaaagagaga
     2641 gaaacaata
//
LOCUS       NM_001437246            1642 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus LSM10, U7 small nuclear RNA associated (Lsm10),
            transcript variant 3, mRNA.
ACCESSION   NM_001437246
VERSION     NM_001437246.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1642)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   2  (bases 1 to 1642)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   3  (bases 1 to 1642)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
REFERENCE   4  (bases 1 to 1642)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.999440.1,
                                           SRR26360172.868169.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-881               JAXUCZ010000005.1  143658592-143659472
            882-1642            JAXUCZ010000005.1  143659631-143660391
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1642
                     /gene="Lsm10"
                     /note="LSM10, U7 small nuclear RNA associated"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
     exon            1..881
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1642
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    882..884
                     /gene="Lsm10"
                     /note="upstream in-frame stop codon"
     CDS             906..1274
                     /gene="Lsm10"
                     /note="U7 snRNP-specific Sm-like protein LSM10"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm10"
                     /protein_id="NP_001424175.1"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
                     /translation="MALSHSVKERTISENSLIILLQGLQGQITTVDLRDESVARGRID
                     NVDAFMNIRLANVTYTDRWGHQVELDDLFVTGRNVRYVHIPDGVNITATIEQQLQIIH
                     RVRNFGGKGQGRREFPSKRP"
     misc_feature    927..1160
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    927..1160
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    order(990..1010,1014..1052,1056..1070)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(990..1010,1014..1052,1056..1070)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(1044..1046,1050..1052,1128..1130)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    order(1044..1046,1050..1052,1128..1130)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    1116..1151
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    1116..1151
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
ORIGIN      
        1 ctcttccctt ggcgcactgg ctgcggactc ttcttcccaa accccttacg cgcggtgagg
       61 aaagggacgc actaggcacc cgactttccc ggattgaccg ctaatggcaa gccccaggcc
      121 tcccttcctg gaagcagcag aaccggagct aaagtcaggg cctgcctgga gatctcaaag
      181 actgtccttt tggattttgt tttaagacag ggtgtcggtc tgtaactcgg agatccacct
      241 gcctctgcct cctgagagct gggcttaaat gcatgcatct tggttggcta ggcttggctt
      301 gttttgtttt ggaaacattc cataatccag attgacccgg agttcacgat atagttcagg
      361 ccggtttggc gtttagggtg cttctcctgc ctcagacttt aatggtataa gtgtgccgcc
      421 atcatgtttg gctagattgc atattaacaa gcgcttggca gaggacatac ataaattaca
      481 atttacagta gtggttctca agccgattgg cacattaaaa ttatcagggg tgcctttaaa
      541 aaaaaaaagg tataaactaa acatagtagc acacgccttt aaatcccagc actagagagg
      601 cagaggtagg aggatcttga tgagtttgag accagcctgg tctacataga gagttccaga
      661 acagccaggg caacctagag aaaccctgtc ccaaaatcat ttaaaaatag cacacacctt
      721 gaatctcagc acctgtgaga agagacaggt tgatctctgc gagttccagg ccacacttgt
      781 ttacatatca agttctagcc tactcaggga gatatagtaa gaccctgtct ttaaaaacaa
      841 caacaaaacc aaaacaatct ggacctctcc ttcccaggca atgagcagcc aaccaatgtg
      901 gaaaaatggc actgagccac tctgtgaagg agcgaaccat ctctgagaac agcctgatca
      961 tcctgttgca aggcctccag ggacaaataa ccactgtgga ccttcgagat gagagtgtgg
     1021 cccgaggacg catcgacaac gttgatgctt tcatgaacat ccgtctggcc aatgtcacct
     1081 acaccgaccg ctgggggcat caggttgagt tggatgacct tttcgtgaca ggtcgtaatg
     1141 tccgatatgt ccatatccca gacggtgtga acatcactgc cacaatcgag cagcagctac
     1201 agatcatcca ccgtgtgcgc aactttggtg gcaagggtca aggtcgtcga gagttcccct
     1261 ccaaaaggcc atgagactgt gtcctcattc aaattccagc accacctcag ggacctccag
     1321 tgttctgagc caactcccgt ccatccttcc ccaccaatga cctggtgtct tatagacaca
     1381 tcacagctgc ctttcatagg gttccacttt tcagacacac cttgggaccc agaattcctt
     1441 ctgctggtgg ccttggggta ggtgacaatc cctctttttg atcatttgta tctggaatct
     1501 ccattcactg attgacccca tccatcaagg agttgttaac tctgccagtg aggattactt
     1561 gagagtgttt ggagtgaatc acctctaaca tcccatttct cttgtcattt gtttcttttc
     1621 tcataaaacc aaactcctgg ga
//
LOCUS       NM_001437315            4830 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), transcript
            variant 2, mRNA.
ACCESSION   NM_001437315 XM_039089363
VERSION     NM_001437315.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4830)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4830)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4830)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039089363.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.30440.1,
                                           SRR26643284.15416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000012.1  16568376-16568531
            157-292             JAXUCZ010000012.1  16579863-16579998
            293-423             JAXUCZ010000012.1  16584164-16584294
            424-1233            JAXUCZ010000012.1  16586457-16587266
            1234-1310           JAXUCZ010000012.1  16588652-16588728
            1311-1413           JAXUCZ010000012.1  16591172-16591274
            1414-1578           JAXUCZ010000012.1  16592806-16592970
            1579-1693           JAXUCZ010000012.1  16597507-16597621
            1694-1833           JAXUCZ010000012.1  16598234-16598373
            1834-1884           JAXUCZ010000012.1  16602723-16602773
            1885-2022           JAXUCZ010000012.1  16604251-16604388
            2023-2171           JAXUCZ010000012.1  16609121-16609269
            2172-2250           JAXUCZ010000012.1  16609681-16609759
            2251-2348           JAXUCZ010000012.1  16658476-16658573
            2349-2571           JAXUCZ010000012.1  16670103-16670325
            2572-2641           JAXUCZ010000012.1  16687074-16687143
            2642-4830           JAXUCZ010000012.1  16687679-16689867
FEATURES             Location/Qualifiers
     source          1..4830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4830
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..156
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            157..292
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="upstream in-frame stop codon"
     CDS             226..2958
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF216"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216 isoform 1"
                     /protein_id="NP_001424244.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTETHKPQTSRPNLIKPAAEWQDLNRLGEERPRKSRADF
                     EADTHSYFSFCNNSLFDSGAQDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTVS
                     PRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEYW
                     LDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGP
                     ASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLVK
                     ETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQ
                     DDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITR
                     KAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHC
                     RSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGE
                     FPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQ
                     TILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQ
                     GLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRC
                     GAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEE
                     EQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPV
                     RPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     misc_feature    1897..2067
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1897..2067
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    2164..2319
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2164..2319
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2350..2520
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     misc_feature    2350..2520
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     exon            293..423
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1233
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1310
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1413
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1578
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1693
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1833
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1884
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2022
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2171
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2250
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2348
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2571
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2641
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..4830
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcggcc tcggcggcag cggcggcggc gacgacagca ttggcagtgg cggctgtagc
       61 agcggggaag cttttcgagc ggatgcttca ggtgacttga gattgaactc ccgggcgtcg
      121 agccccgctc gcggagctgg actagctgcg tggcgaaccc tacagaacag atgatcacca
      181 tgtctgggtt ctagcaatca catacgttta tatctgaatt tgaaaatggc agagggaaac
      241 aaccaagagg aggtcattca cttgaacaac tttcactgcc accgggggaa ggagtggatg
      301 gctgtcagag aggggcccat caccatatct gactcctctg atgaggaagg gattccaatg
      361 ctggttaccc cggctactga gcaacaggaa gacgacctgg atgatgatgt catcctgaca
      421 gaaacacata aacctcagac atcccggccc aatctcatca aaccagctgc cgagtggcaa
      481 gatctgaaca gattgggaga agaaaggcct agaaaatcta gagcagactt tgaagcagat
      541 acccacagct atttttcctt ttgtaacaac tcattgtttg attctggggc acaggatgat
      601 tctgaggatg aatgtggtgg atttctggat cttaagactg agaaaaaagg aggagaagcc
      661 aaacctggac caagcaataa gcagacagca gacaatactg tcagccccag gctggagcag
      721 aaagtcatta ttttgggaga aaatggtctt cttttttcag aaagtgagcc tctggaagtt
      781 cagaaccaat tatctgaaga ctcagagaca gatcttttat caaatcctgg tgagccagct
      841 gcctcagtag atgagcagct aattgaagaa gagtactggc ttgaccatcc ctacttccag
      901 gctctgaatc cacagcctca ggagagaaca aaccagcttg tgccccaaga gcgacattct
      961 gaatcagaaa tgggcccaat gtttttccgc catgatttcc cggagccagc ttttccaagg
     1021 ccagaacccc agcaggaggg gattccagga cccgcttctc cacaaccagc ccatcctcta
     1081 ggagagcttg aagaccagca attagcaatt gatgaagacc ctgggcctgc ctaccccctg
     1141 ccaggacccc aggaggccaa tttggcaaat gtgtggggac aagaagctgc tgaaggggat
     1201 caagagctca ttccactgtt agtgaaagaa acggaagcaa gatttccaga cgtagcaaat
     1261 ggatatgttg aagagataat tcatttgaaa aattactatg atttgaatgt actttgtaat
     1321 tttctcctgg aaaatccaga ttatccaaag agagaagacc gaatccttat ccaccccagc
     1381 agtagcctgc ttgccagcca ggatgatgtg aagttgccta agatagactt ttttgactat
     1441 tccaaattga ctccacttga ccagcgctgc ttcatccaag ctgctgacct cttgatggct
     1501 gatttcaaga tgctcagcag ccaggacatc aagtgggccc tgcacgagct caaagggcat
     1561 tacgcaatca cccgaaaggc cttttctgat gccattaaaa aatggcagga gctatcacct
     1621 gaaaccagtg gaaagcggaa aaagaggaaa gaaatgaatc agtattcttt catagacttc
     1681 aaatttgaac aaggtaacat aaaaatagaa aagaggatgt tctttctgga aaacaagcgt
     1741 cgacactgta ggtcctatga ccagcaggcc ctccttccag ctgtgcagca agagcaggag
     1801 ttctatgagc agaaaattaa agagatggca gagcacgaag attttttgct tgccctgcag
     1861 atgaatgaag agcagtatca aaaggatggc cagctgattg aatgccgctg ctgctatggg
     1921 gagtttccat ttgaggagct gacacaatgc gctgatgctc acttgttctg caaagaatgt
     1981 ctcatcagat atgcccaaga ggccgtgttt ggatctggaa agtcagagct cagctgcatg
     2041 gaaggcagct gcacatgttc cttcccaacc agtgaactgg agaaagtgct cccccagacc
     2101 attctgtaca aatactatga acggaaagct gaagaggaag tcgcagcagc ctatgctgac
     2161 gagcttgtcc ggtgcccctc ttgcagcttc cctgctctgt tggacagcga tgtgaagagg
     2221 ttcagctgcc ctaaccctcg ctgccgaaag gagacctgta ggaagtgtca gggactctgg
     2281 aaagaacaca atggcctcac ctgtgaagag ctggcagaaa aggatgacat caagtaccgg
     2341 acatctattg aagaaaaaat gactgctgct cgaattagaa aatgccacaa gtgtgggact
     2401 ggcctcatca aatctgaagg ctgcaaccgc atgtcttgcc gctgtggtgc ccagatgtgc
     2461 tacctctgtc gagtttctat caatggctat gaccacttct gccagcatcc tcgctctcca
     2521 ggagcccctt gccaggaatg ttccaggtgc tccctctgga ccgaccccac tgaagatgat
     2581 gagaagctga ttgaggagat ccaaaaggag gctgaggagg agcagaaaag aaagaatgga
     2641 gagaacactt tcaaacgcat cgggccccca ctggagaagc cggctgagaa agtgcagcgt
     2701 gtggaagccc tgccacggcc tgtcccacag aacctgcacc ctcagatgcc accctatgcc
     2761 tttgtccacc cacccttccc cctgccacct gtgcggcccg tgttcaacaa cttccccatc
     2821 aacatgggtc ctgtgcccgc accctatgta ccccctctgc ccaacgtgcg tgtcaacttc
     2881 gactttggcc acgtgcatgt gcccctggag cacaacctgc ccatgcactt tggcccccaa
     2941 ccacggcatc gcttctgaca cccaaagccc tgtccagctg tgctgagtct gcaggaggac
     3001 ccagtctcat cctctgagta gggatgaagt cctcgactcc ctatggggtg tgggctcgtg
     3061 tcctcctgct cttcccgttg cgaggtccac tgctccttcg ggtctgatgc gccttgggtg
     3121 ctgactgtcg ctgcaccagt aatagggcag ctccccgggt ctgccatcta tcttagcagc
     3181 cagtccaggg gccttggccg agaagcaggc cctttaagca tttgccatac ttcctcccca
     3241 gcagaccact gaaagcccaa gggaaaatgg cctaccctcc ccaggccagg gctctctcct
     3301 tgttgcccaa ggcccactca ggtccaaggg ccgccaagaa tcttctgtgg cgcaagtttt
     3361 gttctgttgt tacctagagg ttgctcctat tcacatagtt tgagctgaag ttttttgtgt
     3421 gtccccatcc gtggaaagtc aggttgaagg tatttcccca gggctggcaa ctgctgagaa
     3481 ccagtagtcc tgacacttga catcaaacag aaggaccctt ttagggccct ttattcctgg
     3541 gctgcccctt ttctgggaga gacctcactt gtcaccaacc tgggatgagc agcatctctc
     3601 ctaaggtttt taggggcttc cctagcagtg cagatgacct catggagctg ctgcagctat
     3661 cacagcaacc ctcctgcccg ctcagctgtc cctcactagt tagcagtgga tgcagacagg
     3721 agaggtctag ctccaagatg aggacagctg gcttccctag agtcagatga aaatcggcct
     3781 gcacagtctt tgccatgttc ccactacctg tgtcccctcc tgtccagacc agatctttat
     3841 actctcctcc agtgtgtgtt gaccagggct gatagcaagt gtctcactca gttgtactgg
     3901 ctgtccttgt cgtggagtgt cccatgttca gagtgtacag acttagaaga gagaagatgt
     3961 ccctgggaaa aggaaagact ccctgaggtg cccactgtca ctggagtgtg ggtagggcac
     4021 acagggcaac tcaggagccc tgccatgggt cacctgaact gtgatgctag tctgaatgac
     4081 agtgccttgg aaagatgggc cacatgctgc atgacaggat cctccaagta ccttaacaat
     4141 tagtgtactc gtgttctctg cacttctcca gaagccctgc agggggcggt actccgagca
     4201 ctgcccctcc aaggcctcat gagccgctgg actgggcacc cagttctggg cgcctcagta
     4261 ccctatcaca ttgttccacc aagaggccag atggaaaaac tggcagtttc tggggtagct
     4321 ggaagagcag gccaggcagg tgccatccag accctggcac tccatttgga gaggtgaggc
     4381 cagagacgta tccttcaaaa tattgtcagt ctgtgacagg gagactgcta ctgcctgtct
     4441 ccatcaagga gtgaccctcc catgttgcca gcagggctag ggagtgaggg gtgggccagc
     4501 aaggatcccc aaggcagctg ccaccttaac ccctaggacc cagactgctt cctggtttaa
     4561 gaaactgcct agccactccc agtgtatttg ccttaaaact ggagagaatc tagtatttgc
     4621 acttagcaaa agatttcaaa gttaagagaa aagtgcatga tctcactttg tacaaaagaa
     4681 aaaaaggaaa aaaaatgaag tagatggtta aacgtttttc tttacctttt ggtagtaaaa
     4741 atagagaaaa caagtctgtt taaactactg tgtaaaaaga ctgtatcata tgtaacttga
     4801 attttgtgta aataaatgtt tgtgaacgct
//
LOCUS       NM_001107122            4765 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), transcript
            variant 1, mRNA.
ACCESSION   NM_001107122 XM_001064065 XM_039089364 XM_221922
VERSION     NM_001107122.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4765)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4765)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4765)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_039089364.2, NM_001107122.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.40498.1,
                                           SRR26360190.2659199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000012.1  16568376-16568466
            92-227              JAXUCZ010000012.1  16579863-16579998
            228-358             JAXUCZ010000012.1  16584164-16584294
            359-1168            JAXUCZ010000012.1  16586457-16587266
            1169-1245           JAXUCZ010000012.1  16588652-16588728
            1246-1348           JAXUCZ010000012.1  16591172-16591274
            1349-1513           JAXUCZ010000012.1  16592806-16592970
            1514-1628           JAXUCZ010000012.1  16597507-16597621
            1629-1768           JAXUCZ010000012.1  16598234-16598373
            1769-1819           JAXUCZ010000012.1  16602723-16602773
            1820-1957           JAXUCZ010000012.1  16604251-16604388
            1958-2106           JAXUCZ010000012.1  16609121-16609269
            2107-2185           JAXUCZ010000012.1  16609681-16609759
            2186-2283           JAXUCZ010000012.1  16658476-16658573
            2284-2506           JAXUCZ010000012.1  16670103-16670325
            2507-2576           JAXUCZ010000012.1  16687074-16687143
            2577-4765           JAXUCZ010000012.1  16687679-16689867
FEATURES             Location/Qualifiers
     source          1..4765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4765
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..91
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            92..227
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="upstream in-frame stop codon"
     CDS             161..2893
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF216"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216 isoform 1"
                     /protein_id="NP_001100592.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTETHKPQTSRPNLIKPAAEWQDLNRLGEERPRKSRADF
                     EADTHSYFSFCNNSLFDSGAQDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTVS
                     PRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEYW
                     LDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGP
                     ASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLVK
                     ETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQ
                     DDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITR
                     KAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHC
                     RSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGE
                     FPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQ
                     TILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQ
                     GLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRC
                     GAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEE
                     EQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPV
                     RPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     misc_feature    1832..2002
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1832..2002
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    2099..2254
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2099..2254
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2285..2455
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     misc_feature    2285..2455
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     exon            228..358
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            359..1168
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1245
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1348
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1513
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1628
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1768
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1819
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1957
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2106
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2185
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2283
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2506
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2576
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..4765
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcggcc tcggcggcag cggcggcggc gacgacagca ttggcagtgg cggctgtagc
       61 agcggggaag cttttcgagc ggatgcttca gaccctacag aacagatgat caccatgtct
      121 gggttctagc aatcacatac gtttatatct gaatttgaaa atggcagagg gaaacaacca
      181 agaggaggtc attcacttga acaactttca ctgccaccgg gggaaggagt ggatggctgt
      241 cagagagggg cccatcacca tatctgactc ctctgatgag gaagggattc caatgctggt
      301 taccccggct actgagcaac aggaagacga cctggatgat gatgtcatcc tgacagaaac
      361 acataaacct cagacatccc ggcccaatct catcaaacca gctgccgagt ggcaagatct
      421 gaacagattg ggagaagaaa ggcctagaaa atctagagca gactttgaag cagataccca
      481 cagctatttt tccttttgta acaactcatt gtttgattct ggggcacagg atgattctga
      541 ggatgaatgt ggtggatttc tggatcttaa gactgagaaa aaaggaggag aagccaaacc
      601 tggaccaagc aataagcaga cagcagacaa tactgtcagc cccaggctgg agcagaaagt
      661 cattattttg ggagaaaatg gtcttctttt ttcagaaagt gagcctctgg aagttcagaa
      721 ccaattatct gaagactcag agacagatct tttatcaaat cctggtgagc cagctgcctc
      781 agtagatgag cagctaattg aagaagagta ctggcttgac catccctact tccaggctct
      841 gaatccacag cctcaggaga gaacaaacca gcttgtgccc caagagcgac attctgaatc
      901 agaaatgggc ccaatgtttt tccgccatga tttcccggag ccagcttttc caaggccaga
      961 accccagcag gaggggattc caggacccgc ttctccacaa ccagcccatc ctctaggaga
     1021 gcttgaagac cagcaattag caattgatga agaccctggg cctgcctacc ccctgccagg
     1081 accccaggag gccaatttgg caaatgtgtg gggacaagaa gctgctgaag gggatcaaga
     1141 gctcattcca ctgttagtga aagaaacgga agcaagattt ccagacgtag caaatggata
     1201 tgttgaagag ataattcatt tgaaaaatta ctatgatttg aatgtacttt gtaattttct
     1261 cctggaaaat ccagattatc caaagagaga agaccgaatc cttatccacc ccagcagtag
     1321 cctgcttgcc agccaggatg atgtgaagtt gcctaagata gacttttttg actattccaa
     1381 attgactcca cttgaccagc gctgcttcat ccaagctgct gacctcttga tggctgattt
     1441 caagatgctc agcagccagg acatcaagtg ggccctgcac gagctcaaag ggcattacgc
     1501 aatcacccga aaggcctttt ctgatgccat taaaaaatgg caggagctat cacctgaaac
     1561 cagtggaaag cggaaaaaga ggaaagaaat gaatcagtat tctttcatag acttcaaatt
     1621 tgaacaaggt aacataaaaa tagaaaagag gatgttcttt ctggaaaaca agcgtcgaca
     1681 ctgtaggtcc tatgaccagc aggccctcct tccagctgtg cagcaagagc aggagttcta
     1741 tgagcagaaa attaaagaga tggcagagca cgaagatttt ttgcttgccc tgcagatgaa
     1801 tgaagagcag tatcaaaagg atggccagct gattgaatgc cgctgctgct atggggagtt
     1861 tccatttgag gagctgacac aatgcgctga tgctcacttg ttctgcaaag aatgtctcat
     1921 cagatatgcc caagaggccg tgtttggatc tggaaagtca gagctcagct gcatggaagg
     1981 cagctgcaca tgttccttcc caaccagtga actggagaaa gtgctccccc agaccattct
     2041 gtacaaatac tatgaacgga aagctgaaga ggaagtcgca gcagcctatg ctgacgagct
     2101 tgtccggtgc ccctcttgca gcttccctgc tctgttggac agcgatgtga agaggttcag
     2161 ctgccctaac cctcgctgcc gaaaggagac ctgtaggaag tgtcagggac tctggaaaga
     2221 acacaatggc ctcacctgtg aagagctggc agaaaaggat gacatcaagt accggacatc
     2281 tattgaagaa aaaatgactg ctgctcgaat tagaaaatgc cacaagtgtg ggactggcct
     2341 catcaaatct gaaggctgca accgcatgtc ttgccgctgt ggtgcccaga tgtgctacct
     2401 ctgtcgagtt tctatcaatg gctatgacca cttctgccag catcctcgct ctccaggagc
     2461 cccttgccag gaatgttcca ggtgctccct ctggaccgac cccactgaag atgatgagaa
     2521 gctgattgag gagatccaaa aggaggctga ggaggagcag aaaagaaaga atggagagaa
     2581 cactttcaaa cgcatcgggc ccccactgga gaagccggct gagaaagtgc agcgtgtgga
     2641 agccctgcca cggcctgtcc cacagaacct gcaccctcag atgccaccct atgcctttgt
     2701 ccacccaccc ttccccctgc cacctgtgcg gcccgtgttc aacaacttcc ccatcaacat
     2761 gggtcctgtg cccgcaccct atgtaccccc tctgcccaac gtgcgtgtca acttcgactt
     2821 tggccacgtg catgtgcccc tggagcacaa cctgcccatg cactttggcc cccaaccacg
     2881 gcatcgcttc tgacacccaa agccctgtcc agctgtgctg agtctgcagg aggacccagt
     2941 ctcatcctct gagtagggat gaagtcctcg actccctatg gggtgtgggc tcgtgtcctc
     3001 ctgctcttcc cgttgcgagg tccactgctc cttcgggtct gatgcgcctt gggtgctgac
     3061 tgtcgctgca ccagtaatag ggcagctccc cgggtctgcc atctatctta gcagccagtc
     3121 caggggcctt ggccgagaag caggcccttt aagcatttgc catacttcct ccccagcaga
     3181 ccactgaaag cccaagggaa aatggcctac cctccccagg ccagggctct ctccttgttg
     3241 cccaaggccc actcaggtcc aagggccgcc aagaatcttc tgtggcgcaa gttttgttct
     3301 gttgttacct agaggttgct cctattcaca tagtttgagc tgaagttttt tgtgtgtccc
     3361 catccgtgga aagtcaggtt gaaggtattt ccccagggct ggcaactgct gagaaccagt
     3421 agtcctgaca cttgacatca aacagaagga cccttttagg gccctttatt cctgggctgc
     3481 cccttttctg ggagagacct cacttgtcac caacctggga tgagcagcat ctctcctaag
     3541 gtttttaggg gcttccctag cagtgcagat gacctcatgg agctgctgca gctatcacag
     3601 caaccctcct gcccgctcag ctgtccctca ctagttagca gtggatgcag acaggagagg
     3661 tctagctcca agatgaggac agctggcttc cctagagtca gatgaaaatc ggcctgcaca
     3721 gtctttgcca tgttcccact acctgtgtcc cctcctgtcc agaccagatc tttatactct
     3781 cctccagtgt gtgttgacca gggctgatag caagtgtctc actcagttgt actggctgtc
     3841 cttgtcgtgg agtgtcccat gttcagagtg tacagactta gaagagagaa gatgtccctg
     3901 ggaaaaggaa agactccctg aggtgcccac tgtcactgga gtgtgggtag ggcacacagg
     3961 gcaactcagg agccctgcca tgggtcacct gaactgtgat gctagtctga atgacagtgc
     4021 cttggaaaga tgggccacat gctgcatgac aggatcctcc aagtacctta acaattagtg
     4081 tactcgtgtt ctctgcactt ctccagaagc cctgcagggg gcggtactcc gagcactgcc
     4141 cctccaaggc ctcatgagcc gctggactgg gcacccagtt ctgggcgcct cagtacccta
     4201 tcacattgtt ccaccaagag gccagatgga aaaactggca gtttctgggg tagctggaag
     4261 agcaggccag gcaggtgcca tccagaccct ggcactccat ttggagaggt gaggccagag
     4321 acgtatcctt caaaatattg tcagtctgtg acagggagac tgctactgcc tgtctccatc
     4381 aaggagtgac cctcccatgt tgccagcagg gctagggagt gaggggtggg ccagcaagga
     4441 tccccaaggc agctgccacc ttaaccccta ggacccagac tgcttcctgg tttaagaaac
     4501 tgcctagcca ctcccagtgt atttgcctta aaactggaga gaatctagta tttgcactta
     4561 gcaaaagatt tcaaagttaa gagaaaagtg catgatctca ctttgtacaa aagaaaaaaa
     4621 ggaaaaaaaa tgaagtagat ggttaaacgt ttttctttac cttttggtag taaaaataga
     4681 gaaaacaagt ctgtttaaac tactgtgtaa aaagactgta tcatatgtaa cttgaatttt
     4741 gtgtaaataa atgtttgtga acgct
//
LOCUS       NM_001437275            5061 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 3, mRNA.
ACCESSION   NM_001437275 XM_063288139
VERSION     NM_001437275.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5061)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 5061)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 5061)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5061)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5061)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 5061)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 5061)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 5061)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 5061)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 5061)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063288139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.25629.1,
                                           SRR26643429.21985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000005.1  165405713-165405877 c
            166-284             JAXUCZ010000005.1  165403843-165403961 c
            285-457             JAXUCZ010000005.1  165392825-165392997 c
            458-686             JAXUCZ010000005.1  165389591-165389819 c
            687-916             JAXUCZ010000005.1  165389275-165389504 c
            917-1096            JAXUCZ010000005.1  165388373-165388552 c
            1097-1246           JAXUCZ010000005.1  165388101-165388250 c
            1247-1336           JAXUCZ010000005.1  165387693-165387782 c
            1337-1558           JAXUCZ010000005.1  165386476-165386697 c
            1559-1655           JAXUCZ010000005.1  165385787-165385883 c
            1656-1786           JAXUCZ010000005.1  165385559-165385689 c
            1787-1837           JAXUCZ010000005.1  165384765-165384815 c
            1838-2005           JAXUCZ010000005.1  165384521-165384688 c
            2006-2127           JAXUCZ010000005.1  165384309-165384430 c
            2128-2271           JAXUCZ010000005.1  165383996-165384139 c
            2272-2371           JAXUCZ010000005.1  165383697-165383796 c
            2372-2550           JAXUCZ010000005.1  165383289-165383467 c
            2551-2663           JAXUCZ010000005.1  165383088-165383200 c
            2664-2742           JAXUCZ010000005.1  165382877-165382955 c
            2743-2910           JAXUCZ010000005.1  165382365-165382532 c
            2911-3034           JAXUCZ010000005.1  165381666-165381789 c
            3035-3180           JAXUCZ010000005.1  165381296-165381441 c
            3181-3313           JAXUCZ010000005.1  165380825-165380957 c
            3314-5061           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..5061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5061
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..165
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            166..284
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            285..457
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             317..3451
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform a is encoded by transcript variant 3;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform a"
                     /protein_id="NP_001424204.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQ
                     LQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
                     LLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
                     LDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVL
                     MKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTL
                     LEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMD
                     FLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALL
                     NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
                     FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
                     LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
                     VNWLAHNVSKDNRQ"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    860..1159
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    860..1159
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1256..1759
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1256..1759
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1826..2368
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1826..2368
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2342..3442
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2342..3442
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2570..2572,2576..2584,2588..2590,2594..2596,
                     2645..2647,2651..2653,2660..2662,2753..2755,2789..2800,
                     2813..2815,2822..2824,3008..3010,3014..3016,3044..3049)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2570..2572,2576..2584,2588..2590,2594..2596,
                     2645..2647,2651..2653,2660..2662,2753..2755,2789..2800,
                     2813..2815,2822..2824,3008..3010,3014..3016,3044..3049)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2774..2779,3080..3085,3089..3091,3095..3097,
                     3293..3295,3302..3304)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2774..2779,3080..3085,3089..3091,3095..3097,
                     3293..3295,3302..3304)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2915..2917
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2915..2917
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2984..3010
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2984..3010
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    3047..3121
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    3047..3121
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            458..686
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            687..916
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1096
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1246
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1336
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1558
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1655
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1786
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1837
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2005
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2127
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2271
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2371
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2550
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2663
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2742
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2910
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3034
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3180
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3313
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..5061
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcactcac cgccacctcg agcggcgggg cctgccctca ggccctgccg gctgcactcc
       61 gccgcccgga ggctggcgcc ctccggtcac ttcgggaccc tcccgccgtg tcccctgggt
      121 aactgtctcc agggagacgg agcccgcccc tgccaccaac accggacaca taaggagctg
      181 agagccaggc agaagtggga tgaagctccc tgatggcaaa gcacctgtaa tctcccaggc
      241 acaggggcct tggctggtgg tccttctcgg cccatcccaa acaggagaac aggcctcaga
      301 gaagtaacac agcaggatgc cccctggggt agactgcccc atggagttct ggaccaaaga
      361 ggagagccag agcgtggccg ttgacttctt gctgcccaca ggagtctact tgaacttccc
      421 tgtgtcccgc aatgccaacc tcagcaccat caagcaggtg ctgtggcatc gtgcacagta
      481 tgagccgttc ttccacatgc tcagtgaccc cgaggcttat gtgttcacct gtgtgaacca
      541 gacagcggag cagcaggagt tggaggatga gcagcggagg ctgtgtgaca tccagccctt
      601 cctgcccgtg ctgcgcctgg tggcccgaga gggggaccgc gtgaagaagc tcatcaactc
      661 acagatcagc ctcctcatcg gcaaaggtct ccatgagttt gattccctgc gggacccgga
      721 agtaaacgac ttccgcacta agatgcgcca gttttgcgaa gaggccgcgg ctcaccgcca
      781 gcagctgggc tgggtggaat ggctgcagta tagcttcccc ctgcagctgg agccctcagc
      841 cagaggttgg cgggctggct tattgcatgt cagcaaccga cccctgctgg tcaatgtgaa
      901 gttcgagggc agtgaggaga gcttcacctt ccaggtatcc accaaggaca tgcccctcgc
      961 actgatggcc tgtgccctcc gaaaaaaggc caccgtgttc cggcagcctc tggtggagag
     1021 gcctgaggag tatgccctgc aggtgaacgg gaggcacgag tacctctacg gcagctaccc
     1081 cctctgccac tttcagtaca tctgtagctg cctgcacagc ggactgactc cccatctgac
     1141 catggtccac tcctcctcca tcctcgccat gagggatgag cagagcaacc ctgcccccca
     1201 ggtgcagaag ccacgagtca aacctccccc gatccctgcc aagaagccct cctctgtgtc
     1261 cctgtggtcc ctggaacagc cattctgcat tgagctgatt gagggccgca aggtgaatgc
     1321 ggatgaaagg atgaagctgg ttgtgcaggc cgggctcttc cacggcaatg agatgctgtg
     1381 caagactgtg tcgagctcag aggtgaatgt gtgctcagag cccgtgtgga agcagcgact
     1441 agaattcgac atcagcatct gtgacctccc ccgaatggcc cggctctgct ttgcactcta
     1501 tgctgtcgtg gagaaggcta agaaggcgcg ctccacaaag aagaagtcca agaaggcgga
     1561 ctgtcccatc gcttgggcca acctcatgct attcgactac aaagatcagc tcaagacggg
     1621 cgaacggtgc ctctacatgt ggccctctgt cccagatgag aaaggggaac tgatgaatcc
     1681 tgcgggtaca gtacgtggta accccaacac agagagtgcc gctgccctgg tcatctacct
     1741 acctgaggtg gctccccacc ctgtgtactt ccctgctctg gagaagatcc tggagctggg
     1801 gcgtcacggg gagcgtgggc gcatcacaga ggaggagcag ctgcagctgc gggagatcct
     1861 ggagcggcgg ggatctgggg aactgtacga acatgagaag gacctggtgt ggaagatgcg
     1921 tcacgaagtc caggagcatt tcccagaggc gctggcccgc ctgctactgg tcaccaagtg
     1981 gaataaacat gaggatgtgg cccagatgct ctatttgctg tgctcctggc ccgagcttcc
     2041 tgtgctgagc gccctggagc ttctggactt tagttttcct gactgctacg tgggttcctt
     2101 cgccatcaag tccctacgga agctgacgga tgacgagctt ttccagtacc ttctgcagct
     2161 ggtacaagta ctcaaatatg agtcctacct ggactgcgag ttgaccaaat tcttgttggg
     2221 ccgagccctg gctaaccgca agatcgggca cttcctgttc tggcacctcc gctctgagat
     2281 gcatgtaccg tccgtggccc tgcgttttgg cctcatcatg gaagcctact gcagaggcag
     2341 cacccaccac atgaaggtgc tgatgaagca gggggaggca ctgagcaagc ttaaggccct
     2401 gaatgacttt gtgaaggcga gctcgcagaa gaccaccaag ccccagacca aggagatgat
     2461 gcatatgtgt atgcgccagg agacttacat ggaggcgctg tcccacctgc agtctcccct
     2521 cgaccccagc accctgctgg aggaagtctg tgtggagcag tgcaccttca tggactccaa
     2581 aatgaagcca ttgtggatca tgtacagcag cgagaaggca ggcggtgccg gcagcgtggg
     2641 catcatcttt aagaacgggg atgacctccg ccaggacatg ctgactctgc agatgatcca
     2701 gctcatggac ttcctatgga agcaggaggg cctggacctg aggatgaccc cctatggctg
     2761 cctccccacc ggagatcgca caggcctcat tgaggtggtc ctccactcgg acaccatcgc
     2821 caacatccag ctgaataaaa gcaacatggc agccacggct gcgttcaaca aggacgctct
     2881 gctcaactgg ctcaagtcta agaaccctgg ggaggctctg gatcgggcca ttgaggaatt
     2941 caccctctcc tgtgctggct actgtgtggc cacatatgtg ctgggcatcg gtgaccggca
     3001 cagcgataac atcatgatca gagagagtgg gcagcttttc cacattgact ttggccactt
     3061 tctggggaac ttcaagacca agttcgggat caaccgggag cgtgtcccct tcattctcac
     3121 ctacgacttt gtccacgtga tccagcaggg gaagactaac aacagtgaga aatttgaaag
     3181 gttccgaggc tactgtgaac gagcctacac catcctgcgg cgtcacgggc tgcttttcct
     3241 tcatctcttc gccctcatgc gcgcagcagg tctgcctgag cttagctgct ccaaagacat
     3301 ccagtatctc aaggactctc tggcactagg gaagacggag gaagaagcac taaagcactt
     3361 ccgggtgaag ttcaatgaag ctctccggga gagctggaaa accaaagtca actggctggc
     3421 acacaatgtg tccaaggata acaggcagta agaggcgccc ccctgggcgt cacattcccc
     3481 tgggcgtcac atggcagttc cctggttccc tccgggctct cagccataga ggtaaactgt
     3541 cagtcctgga gaccaggcat gctcagtggt catcaaaggg gccccagacc tgaactgtcc
     3601 ctcacagaga agaaccacac aactgcttct tgtttacact ggttatttat ttatgactcg
     3661 aaatgtttaa ggaacagaat agccataaat ggaagtgcat ttttgtgcag gggaggggtg
     3721 ctgtcctcgt gaccccccct ccctcagcac tgtaaacagc accttgagga tcgtacccct
     3781 agtcttccaa cctgtgggtc ttggcccccc aaaggcagtt ttgggggcca ccttcccagg
     3841 ctcccagccg gctgcctaga acaagcctgg cagtcacctg gtgcctccca cgcagacagg
     3901 acacctcaat cctcagctca gctcacctcc gccaccttca tgtggcccac cctcggcgac
     3961 ctccatctac caagcctccg gcagctcctg aggaagccag gagcttccct ctagactcag
     4021 gcacacttgc tctgcactgc tgaagtgaca acctcttggg tacggaaaca ccctcacctt
     4081 ttatttgcgg gtaagaacat gattatgtaa actctgtata gaatagccgg ggtaaaggac
     4141 ctggcttcca ctacagatag ctgtgttctg ggcctcaaaa cactagagat tggtgcccga
     4201 tttagtgcgg tgtggtcgtg aatccagaca aagggcaagc ctgaacggag tcctcttcgc
     4261 aatttgtgtg agaaccgcac acaaaggcag ctttctggaa ggacaggact gatgtctccc
     4321 agagctgcca ttctcagaag gcagctgggg tcccgggttc tgaagtgtgc gcgaggagga
     4381 ggaccaagtt tagtagtctg ggcgactgga gcatctccag aaatgcaggg tctccacccc
     4441 ctcccaggta tccaaaccta ctttgggctg tagagccagt cacctggctt tttagagagc
     4501 ccagctcagt ggtgcacatg cataaaacgt gccatcccga gcccaccgtg atgcatcagc
     4561 tgccgcctca ggacctggct ctcccggtaa catcctgaga cttgcagaac catcaccgcc
     4621 gtcttgctgg cagcccagaa catggctgct caaggaagcc aggtgtccgc tctttcacga
     4681 tgatgaactg agggtccagc agtggttggt gcctccaggg cacttgctga acccttagtc
     4741 tgccccaact ctgaaatagg aagtgtgcgt gcgtgtgcgt gcgtgtgcgc gtgtgtgccg
     4801 tgttatttat tgaaaagagt ctaggtgctc cctggtgtgg ctgcagattc tgcagaggct
     4861 cagcctttct gggttgggta tgtggtctgt gtacctggct ggaaaagtat tttctatttt
     4921 ttttttttaa aagttgttct acgtttctgt aggggggaag gtagatttcc tctcactgat
     4981 gtgggctgag atcagtctgt gcaaccctga cacgtccggt aaagacaggt gaaaagaaat
     5041 aaaaatcttt ttatgttctt a
//
LOCUS       NM_001437236            3537 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 3, mRNA.
ACCESSION   NM_001437236 XM_063271162
VERSION     NM_001437236.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271162.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.84522.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000012.1  32093206-32093268   c
            64-128              JAXUCZ010000012.1  32090917-32090981   c
            129-223             JAXUCZ010000012.1  32090152-32090246   c
            224-401             JAXUCZ010000012.1  32079959-32080136   c
            402-687             JAXUCZ010000012.1  32077686-32077971   c
            688-838             JAXUCZ010000012.1  32072686-32072836   c
            839-1022            JAXUCZ010000012.1  32071923-32072106   c
            1023-1166           JAXUCZ010000012.1  32070118-32070261   c
            1167-3537           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3537
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..63
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            64..128
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            129..223
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    213..215
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            224..401
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1187
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001424165.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    270..1013
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    270..1013
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    303..365
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    474..560
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    777..839
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1050..1112
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            402..687
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            688..838
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1022
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1166
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..3537
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatgatca cccactgccg gtgtggacac atcacatgct gtggttctca gtgatcacat
       61 aacagcgcta ggattaaagg catgcaaggc ggaagatacc aggatctcca aggaaattgc
      121 agataaagcc acatctgtga aggaaactca tgtctaagag caccccgacc tttgacactc
      181 taaggacagg tggatgtgat ctttaccaca gatgaccctt tcggttgccg ctggtgagaa
      241 gcatgttcag cattaacccc ttggagaacc tgaagctgta catcagcagc cggccaccgt
      301 tggtggtttt tatgatcagt gtcagcgcca tggccatcgc cttcctcacc ctgggctact
      361 tcttcaagat caaggagatt aagtccccag aaatggctga ggattggaat actttcctgc
      421 tccggtttaa tgatttggac ttgtgtgtat cagaaaatga gacactgaag catctctcca
      481 acgataccac cacacctgag agcaccatga ccatcgggca aaccagatcg tccacccagc
      541 cgccccagtc cctggaggag tcaggcccca tcaatatttc agtggccatt accttgacct
      601 tggaccctct caagcccttt ggagggtact ctcgaaatgt cacacacctg tactccacca
      661 tccttggcca tcagattgga ttgtcaggca gggaagccca tgaggagatc aacatcacct
      721 tcaccctgcc tgctgcctgg aatgccgatg actgtgctct ccatggccac tgtgagcagg
      781 tggtgttcac agcatgcatg accctcacag ctgcccctgg agtcttccct gtcaccgttc
      841 agccacctca ctgtgtcccc gacacataca gcaacgccac actctggtac aagatcttca
      901 caactgccag agatgccaac acgaaatacg ctcaagacta caaccctttc tggtgttaca
      961 agggcgccat tgggaaagtc taccacgctt taaatcccaa gctcaccgtc attgtcccag
     1021 atgacgaccg ctccttaata aacctgcatc tcatgcacac cagttacttc cttttcgtga
     1081 tggtgataac gatgttctgc tatgcagtta tcaaaggcag acccagcaaa ctgcggcaga
     1141 gcaatcctga attttgccct gagaaggtgg ctttggctga tgcctaatcc cacagctccc
     1201 cattttctga gagaccaaga accatgatca ttgcctgctg aatcggccag ggcctggcca
     1261 ctctgtgaat acacgatctt gcaatgttgg gttattccag ccaaagacat ttcaagtgcc
     1321 tgtaactgat ctgtacatat ttataaacgt tgatctggaa actggtcctg tggtgcacgt
     1381 gctttgccct ggatgcggcc ggaacccgtc agcctcactg aggggcagga gggcactgac
     1441 atggggttct tccatgaagt gccgggggat gtgggaatct tgccagagct gagcgtgtcg
     1501 tgttccaaca ccagcggccg aggttggctg cggttcttgt ctcagacggg ggtgtgcagt
     1561 gttggacgct gtgtgcacct ttgtcaggac actgtttcag aagccaccat tccctcctgc
     1621 ggctctcacg tgtctcagtg accatatagc gacagcagta gttccttctc agtttgcttg
     1681 caaggaaact gtttttaaaa gagaaaacaa gctacatttt atattcccct tgttaggaca
     1741 gacaggcttg tctatccagg tcaaaggtca cgcccccaag gcatttctgt agtgaagagc
     1801 agagttccgt ctccacactg gcccctagga actggagtgc tttgctcctc tgtgctcctg
     1861 gtagagaagt tcctggcttg agaagtggcg gtgtaatggg gacacagggc agcacaggct
     1921 gcctaacttc acaaggcaga agagatggcg ggctgctgta atgctcacaa gcagggcttg
     1981 cttttttttt ctttctaaaa ttcgtttcgc attcattttt gtacatcaca catctatctc
     2041 cagaaggaga atgaacatta taggtatata atgtggagct ggtgcaggga agatctgaag
     2101 gaagaaggcg tatgaggcgc tgatggctgg ccagtcaaaa ccagaagcgt tttccttagg
     2161 acagttgtga ccatccggcc ccagtgccct ctcgcatttc ctttaggaaa gtcattcgca
     2221 ttcccttctg cgagttactt gtatttgcag tggttttcta tcaatgcctt gccttaatgc
     2281 ccatgcagtg ttcttccagg cagtgttcca gacttgctgg gtgtgaggat gaatgcatgt
     2341 taggagcagc cctctggagg ccgagggagg agaatctcga gtgcgaggct ggcctgggcc
     2401 acatactgat agcctgtctc acaggaagaa aaactactta ggtatgtcag cacttctgtc
     2461 ccgtaactgt aggtctgtct cagttgcagt taacttgctg tatcccgaac cttactggcc
     2521 tagagaattt tatcccaggc attcttagat ggaaaacaat actttggatt tttgttctaa
     2581 attgaagctt gtgaaaataa tcactgtagt taggtgacgc cctaatgttt tttaaagcag
     2641 aggtgagtta cttataagat ggctaatgtg tgaatttcat ttagtcttcc cttagacttt
     2701 gagagccttg tcaggcagga tggagaaaac ccacgtggct tagctggtat gaatgtgtca
     2761 tcaggaccat caagtttcag attaagtagt aagacccagt agagtaagac atgagaagaa
     2821 atcaccttca ttggtctgtc ggctgtgttc ctcttagtca tccttgtgtt aatgacaggc
     2881 agtggctggg atttgtagag ggtgggaagg aggaacacca taagacctgg ggagaggaag
     2941 tccccaaaat gcttgagagt gacccatcct gaggccagat acatatttta aagcccaagt
     3001 attcgccata gcaggtagac agatggagga tggctgggga aggaggttgt gggctgagtt
     3061 taggggactg cagacacatc tgggcctggt cctcagctgc tccttggtgg taaacctcaa
     3121 aaatggcatg tcagattggc cactagagac ctctgacccc agcagcactg gcttgtcctc
     3181 aggtgtgggt gtgtcagaag tcagtgactt cctgggaaat ggttgtttcg gatcacattg
     3241 atctttcctt ttgtctttca ccgtatggta ggacttgaat cagttttgat tctgtgtgta
     3301 cgttctcttc gtttggaacc tggcgtttct gtctgttctt ggcagtgcat aggaacccag
     3361 cctcctgtat tttgaccctc ctgcaggcac tgtgggaccc aagggtagca gatccatctc
     3421 ccgtcccttg ctgcatgatg gtcactagct gatctgtgat ggcatccctc cctcattgat
     3481 tttctgtgtt tgaagtatgt gcacatgtgc tttacagaat aaaacatctg gatttac
//
LOCUS       NM_001437231            1598 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 9 open reading frame
            153 (C17h9orf153), transcript variant 2, mRNA.
ACCESSION   NM_001437231 XM_063276009
VERSION     NM_001437231.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063276009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.819143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000017.1  4980936-4981022
            88-270              JAXUCZ010000017.1  4981452-4981634
            271-366             JAXUCZ010000017.1  4985033-4985128
            367-856             JAXUCZ010000017.1  4986300-4986789
            857-1598            JAXUCZ010000017.1  4987547-4988288
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1598
                     /gene="C17h9orf153"
                     /note="similar to human chromosome 9 open reading frame
                     153"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
     exon            1..87
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            88..270
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    232..234
                     /gene="C17h9orf153"
                     /note="upstream in-frame stop codon"
     exon            271..366
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1104
                     /gene="C17h9orf153"
                     /note="isoform 1 is encoded by transcript variant 2;
                     uncharacterized protein C9orf153 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153 homolog isoform
                     1"
                     /protein_id="NP_001424160.1"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
                     /translation="MSSTRHHTWTRGSIGSLYLHRCSLPELYASLEIFNKESKKSNLQ
                     KICGMSFKEAQEVLWKILGGLISDSYDTVKGDERHPSIPVNKEERKTPSMSDLLHQSL
                     LKGYNVPLEQVHSSQQRLAQVGIPPPPLSFPHGLSNELPVILPAQHFRKRIQSVTFRK
                     LLLSSVAPGRLFYEEKPTSQQVSFDPGKQFLDLADLQWRYFKGLAKWGKMPRRFSLLN
                     IEYNSEKRYVENQRMSGLIFPPLVRKTLMVYPQAEYDKEGQLYLTWKIVY"
     misc_feature    298..573
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     misc_feature    298..573
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     exon            367..856
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1598
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgagcct gcggtctacc aggtgaagga tactcagcct gggacttcag agattaccca
       61 caaaggtgga ccacgggaaa ctaagcaagc tagtgctcat gagaaagcta cctcctttga
      121 accatgatgg aatatgattt gtgaacaatg aaaagatgtg taaggtcaaa ctgggttcca
      181 acctacgctg ctgggatgaa ctctccctgc cacagcgggc ctggcaatcc ttaaggacac
      241 cacccatcca accaagacgt ccctaagcag gaacgtggag gttcagatct tggcacaatg
      301 tcctccacca gacaccacac ttggacccga ggcagcatag gatccctgta tctgcaccgt
      361 tgttcgctac cagaattata tgcatcactt gagattttta ataaggagag caagaaatct
      421 aatctccaaa agatctgtgg catgtcgttt aaggaagctc aggaagtcct ttggaaaatc
      481 ctgggtggcc tgatctctga cagctatgac accgtaaaag gggatgagcg ccacccttcc
      541 ataccggtta acaaagagga gcggaagaca ccatctatgt cagatctact tcaccaaagt
      601 ctgttaaagg gttacaatgt tccgttggag caggtacaca gctcccagca gaggctggcc
      661 caggtgggca tccctcctcc tccactctcc tttcctcacg gtttaagcaa cgaactgccc
      721 gtgatccttc cagcacagca cttcaggaaa aggattcaaa gcgtcacatt ccgcaaactt
      781 ctcctgtctt ctgttgcccc aggcaggctg ttctatgaag aaaagccaac aagccaacaa
      841 gtctcctttg acccaggaaa gcagttccta gacctggcag accttcagtg gaggtatttc
      901 aagggacttg caaagtgggg gaaaatgccc aggaggtttt ccctcttgaa catagaatac
      961 aacagtgaga agagatacgt agagaaccaa cgtatgtctg gactcatctt ccctccccta
     1021 gttcgcaaga ctctgatggt ctaccctcaa gctgagtatg ataaagaagg acagctttat
     1081 ctcacctgga aaatagtgta ctgaaatagt ctggatatga accgttctgc ttgggattgc
     1141 cgaaccaaca caagaggtgg aaaagcacac agcccacttc tctactcaat gtccgtgcaa
     1201 agcctacatt aaaatgattt cgtggaggaa catgtccaac caatctgctg gcattactct
     1261 ggttcacagt tctgatgctc atctgaacag caggtgaagg gaatactggg tggatacaca
     1321 gaaatagctc tccaccaaaa atggatctct acaatgtttt cttccttggt ttctctgttt
     1381 ctttgtttct ggtttgttta tttgtttgtt tgtttgttta ctttttgctg tcaatatgta
     1441 atttacttac ttaaaaaaat ccaaattctg gcattgtcta gaaaatttca gtaggtttta
     1501 aagttgaact gttgaaatgt gttcacggaa gcattctgct tgcattaatg ctttacacgg
     1561 tgcatgtata ttaaaagtca cacccaaatg aacgtgga
//
LOCUS       NM_001437233            1405 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 9 open reading frame
            153 (C17h9orf153), transcript variant 5, mRNA.
ACCESSION   NM_001437233 XM_063276011
VERSION     NM_001437233.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063276011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1239906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000017.1  4980936-4980957
            23-205              JAXUCZ010000017.1  4981452-4981634
            206-301             JAXUCZ010000017.1  4985033-4985128
            302-791             JAXUCZ010000017.1  4986300-4986789
            792-828             JAXUCZ010000017.1  4987547-4987583
            829-1405            JAXUCZ010000017.1  4987712-4988288
FEATURES             Location/Qualifiers
     source          1..1405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1405
                     /gene="C17h9orf153"
                     /note="similar to human chromosome 9 open reading frame
                     153"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
     exon            1..22
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            23..205
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="C17h9orf153"
                     /note="upstream in-frame stop codon"
     exon            206..301
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..862
                     /gene="C17h9orf153"
                     /note="isoform 2 is encoded by transcript variant 5;
                     uncharacterized protein C9orf153 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153 homolog isoform
                     2"
                     /protein_id="NP_001424162.1"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
                     /translation="MSSTRHHTWTRGSIGSLYLHRCSLPELYASLEIFNKESKKSNLQ
                     KICGMSFKEAQEVLWKILGGLISDSYDTVKGDERHPSIPVNKEERKTPSMSDLLHQSL
                     LKGYNVPLEQVHSSQQRLAQVGIPPPPLSFPHGLSNELPVILPAQHFRKRIQSVTFRK
                     LLLSSVAPGRLFYEEKPTSQQVSFDPGKQFLDLADLQWSSQDSDGLPSS"
     misc_feature    233..508
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     misc_feature    233..508
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     exon            302..791
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            792..828
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1405
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgagcct gcggtctacc agagctagtg ctcatgagaa agctacctcc tttgaaccat
       61 gatggaatat gatttgtgaa caatgaaaag atgtgtaagg tcaaactggg ttccaaccta
      121 cgctgctggg atgaactctc cctgccacag cgggcctggc aatccttaag gacaccaccc
      181 atccaaccaa gacgtcccta agcaggaacg tggaggttca gatcttggca caatgtcctc
      241 caccagacac cacacttgga cccgaggcag cataggatcc ctgtatctgc accgttgttc
      301 gctaccagaa ttatatgcat cacttgagat ttttaataag gagagcaaga aatctaatct
      361 ccaaaagatc tgtggcatgt cgtttaagga agctcaggaa gtcctttgga aaatcctggg
      421 tggcctgatc tctgacagct atgacaccgt aaaaggggat gagcgccacc cttccatacc
      481 ggttaacaaa gaggagcgga agacaccatc tatgtcagat ctacttcacc aaagtctgtt
      541 aaagggttac aatgttccgt tggagcaggt acacagctcc cagcagaggc tggcccaggt
      601 gggcatccct cctcctccac tctcctttcc tcacggttta agcaacgaac tgcccgtgat
      661 ccttccagca cagcacttca ggaaaaggat tcaaagcgtc acattccgca aacttctcct
      721 gtcttctgtt gccccaggca ggctgttcta tgaagaaaag ccaacaagcc aacaagtctc
      781 ctttgaccca ggaaagcagt tcctagacct ggcagacctt cagtggagtt cgcaagactc
      841 tgatggtcta ccctcaagct gagtatgata aagaaggaca gctttatctc acctggaaaa
      901 tagtgtactg aaatagtctg gatatgaacc gttctgcttg ggattgccga accaacacaa
      961 gaggtggaaa agcacacagc ccacttctct actcaatgtc cgtgcaaagc ctacattaaa
     1021 atgatttcgt ggaggaacat gtccaaccaa tctgctggca ttactctggt tcacagttct
     1081 gatgctcatc tgaacagcag gtgaagggaa tactgggtgg atacacagaa atagctctcc
     1141 accaaaaatg gatctctaca atgttttctt ccttggtttc tctgtttctt tgtttctggt
     1201 ttgtttattt gtttgtttgt ttgtttactt tttgctgtca atatgtaatt tacttactta
     1261 aaaaaatcca aattctggca ttgtctagaa aatttcagta ggttttaaag ttgaactgtt
     1321 gaaatgtgtt cacggaagca ttctgcttgc attaatgctt tacacggtgc atgtatatta
     1381 aaagtcacac ccaaatgaac gtgga
//
LOCUS       NM_001437382             763 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 6, mRNA.
ACCESSION   NM_001437382 XM_039094842
VERSION     NM_001437382.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039094842.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2469682.1,
                                           SRR26360194.1476070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000016.1  82528885-82529058   c
            175-255             JAXUCZ010000016.1  82512490-82512570   c
            256-763             JAXUCZ010000016.1  82504477-82504984   c
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..763
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..174
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             85..309
                     /gene="Cfap97d2"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 6"
                     /protein_id="NP_001424311.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKELIVKPNKATASSGCAA"
     exon            175..255
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..763
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatgaccc cgcaaacagc tctgcggggg ctgtactgct gtgcctgctc ttccctgaag
       61 ggaccctgga gtttgtgatc tgagatgcat agagtgcccc agctgaccac cccgtgggct
      121 agtagagacc tgcagagagc ctgggagaaa acctaccaga accacaggaa aaaggtccag
      181 aacgcccaac cactcgtgga cacccgccca ccacagactt acagccacct ccacctaaag
      241 ttcaagaagt tgaaggagct gatcgtgaag cccaacaagg ccacagcctc atctggatgc
      301 gcagcctgaa gcggaagggg tgagggttca cgacccaacc accgaaagaa gaccagggcc
      361 tggaagctcc gatgaggcct tcctgtgtct cccaggggtg ggggtgggga tgtggggtgt
      421 gcaggtctag catccgagat cacgctggct ctggggacgg ctgtgggagc tgtgacgcgg
      481 cactctgaag cttcacggtc acggccgtcg ccagatgaca cagcacggct gtttactgtg
      541 tttcttggac cgataaccaa aaacaaaata tgcagagtga ctctgcgagt tacaggattt
      601 gaattagacg actctccttt ctagctgtta ctacttctct gagttaacat gagtttgggc
      661 gggtgtatgt aattctcttt aaaaacaaca acagaacaaa caaaaatacc tctgtgactg
      721 tcattttacc aagtatgtaa ataaatcaaa ctgagagctt taa
//
LOCUS       NM_001437361            2433 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 10, mRNA.
ACCESSION   NM_001437361 XM_063271322
VERSION     NM_001437361.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271322.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               JAXUCZ010000012.1  40090950-40091552
            604-704             JAXUCZ010000012.1  40093232-40093332
            705-874             JAXUCZ010000012.1  40093729-40093898
            875-1064            JAXUCZ010000012.1  40096705-40096894
            1065-1184           JAXUCZ010000012.1  40098953-40099072
            1185-1366           JAXUCZ010000012.1  40100973-40101154
            1367-1548           JAXUCZ010000012.1  40102786-40102967
            1549-1769           JAXUCZ010000012.1  40106323-40106543
            1770-1844           JAXUCZ010000012.1  40109132-40109206
            1845-2037           JAXUCZ010000012.1  40110908-40111100
            2038-2241           JAXUCZ010000012.1  40112332-40112535
            2242-2433           JAXUCZ010000012.1  40113629-40113820
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2433
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..603
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            604..704
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    699..701
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             705..2381
                     /gene="Ccdc63"
                     /note="isoform 2 is encoded by transcript variant 10;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     2"
                     /protein_id="NP_001424290.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVEYPLDHSSLRQLVLENYLQKERGKEPQETLLEKGDEIRVKKKVIS"
     misc_feature    <1140..1961
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1140..1961
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            705..874
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1064
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1184
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1366
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1548
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1769
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1844
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2037
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2241
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2433
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggta agttagggta cacacagcgc
       61 cccctgccgg cgatgagcac aggctggggg ctccggcaag ccaggaacca gcaactgcca
      121 ccgtaaatgc tccccaagcc caaagagcgg tatcttcttc caagcgtcct tgtatttatt
      181 tatcgcttat ccactcattt atttgagaca gtgttatatc agaggctggc cttgaagtcg
      241 cgctacagcc aaagatgatc ttgacctcgt gaatcttcct ttctccacct cccaggggct
      301 gggatgtcag gccagtaccg ccaaacccag cttcatgttt ctttttaaaa caaaccgtgt
      361 cactcactca ggatccccgc agaacccacc ttgtcattta gaagcgggac ggaagtgtgg
      421 gctccctact ttggctgtta cacgggagat gggaaagata gcggggacta atgaactggg
      481 agatgttcag gaggcctggg gaaggtcatt cattcaagct gtgcttggga gagctgactt
      541 ctccccatcc ggaaggctcc agaaaccaag acgtggtcta tggtcatgac ctgtccactc
      601 actgacattg cagacagagg agacactgag agaacgagaa agaagtgggc ttgctagctt
      661 tgacctccag gacccagtgt ctaagcagaa aggaagctta gacgatgaag aaacacagga
      721 ggaaggtctc tgaacccctt ccggaacttt ccgagaaggc caaagagcag ttggctgagg
      781 cagagctacg gaaactaagg cagcagttcc ggaagatggt agacagccga aagtcttcca
      841 atttccgcaa ccagcggatg atcgccagcc agtacaagga gatagagaat ttgaaagcgg
      901 agcaggcaga gaccaccttg cttctgagcc tcgtgaagtc gccaaagaac ctagacctca
      961 accagaaaaa tttcacggag ctgcgcttcc tgctgcagac caagggggac tacgaggctc
     1021 tgatctcctc catgaaggtg ctgctgggag aactggatga caagattgtt cagatggaga
     1081 gaaagatcac aaaccagaga cagatcttct tgaagacaca agaggccaac aatccccgga
     1141 agctgcagaa acagatccac attctggaga ccagactgaa cctggtcact gtccactttg
     1201 acacgatgtt gacctccaat gcccagctcc ggaaggatat tgaggatctt ctctttgaga
     1261 aggctgccta cgaccatgtc taccagcagc ttcagcggcg tctgcagaca cagaagaaga
     1321 ccatgaatgt ggccatcgag cagtctaccc aggcctatga gcagagagtg gaagccatgg
     1381 ctcggatggc tgccatgaag gaccgccagc aaaaagacat ctctcagtac aacctggaga
     1441 tccgagagct cgaacgcctg tatgaccacg agaacaaact caagtccttt ctgcttgtca
     1501 agctcaatga ccgcacggaa ttcgaggacc aggccaagaa gcaggaagct gtcaaaatta
     1561 agaagcatgg gaaaaagagg aagggtgaga gctttgagag ctacgaggtg gcccatctcc
     1621 gactgctaaa gctggctgag aacggggacc tgaaccagct cactgaggac ttcctggcca
     1681 aggaggagaa gaattttgct cgcttcacct atgtcaccga gctcaacaat gacatggaga
     1741 ccatgcacaa gaggacccag cggatccagg atgacatcat caacctgcgg tcacagcagc
     1801 agtcctccca tgagggcacc cggaacatcc tgaaacagat ggaggagaaa ctgaggaaga
     1861 ccaccgagga cacggacatt tatgagaaca ggtacaggga aatgagcaag accctggagt
     1921 acctcaagaa ctcagtggag aagctgttta agaagatcaa ctgcaatgcc acggagatcc
     1981 tggggaaact gggtgagact gggaagatca cggacagcaa ccttcagcag tacttcgcta
     2041 tcatagaaaa gaagacaaat gacctcctgc ttctggagtc tttccggcgc ctgcaggagg
     2101 cagaggggcc cgatgttgat gtcccacaac cctttgtcaa ccccttctgg gggggctctg
     2161 ccctcctcaa gcccccagag cccttaaggg ttgtgccgcc tgtgtttggg gcagactcct
     2221 tcagtgacaa agttgaagag gtggaatacc ctctggacca cagtagcctc cggcagctgg
     2281 tcttggagaa ctaccttcag aaggaacgag gaaaagaacc acaggagaca ctgttggaga
     2341 agggggacga gataagggtc aagaagaagg tgataagctg aaccccgtgg gtggctgtat
     2401 tccacaccga gaaaataaat gttttcttgc cga
//
LOCUS       NM_001437405            2215 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus myotilin (Myot), transcript variant 3, mRNA.
ACCESSION   NM_001437405 XM_006254667
VERSION     NM_001437405.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   von Nandelstadh,P., Ismail,M., Gardin,C., Suila,H., Zara,I.,
            Belgrano,A., Valle,G., Carpen,O. and Faulkner,G.
  TITLE     A class III PDZ binding motif in the myotilin and FATZ families
            binds enigma family proteins: a common link for Z-disc myopathies
  JOURNAL   Mol Cell Biol 29 (3), 822-834 (2009)
   PUBMED   19047374
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Hauser,M.A., Horrigan,S.K., Salmikangas,P., Torian,U.M.,
            Viles,K.D., Dancel,R., Tim,R.W., Taivainen,A., Bartoloni,L.,
            Gilchrist,J.M., Stajich,J.M., Gaskell,P.C., Gilbert,J.R.,
            Vance,J.M., Pericak-Vance,M.A., Carpen,O., Westbrook,C.A. and
            Speer,M.C.
  TITLE     Myotilin is mutated in limb girdle muscular dystrophy 1A
  JOURNAL   Hum Mol Genet 9 (14), 2141-2147 (2000)
   PUBMED   10958653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254667.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.56275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000018.1  36956191-36956275
            86-623              JAXUCZ010000018.1  36959057-36959594
            624-798             JAXUCZ010000018.1  36963587-36963761
            799-900             JAXUCZ010000018.1  36964671-36964772
            901-950             JAXUCZ010000018.1  36967664-36967713
            951-1083            JAXUCZ010000018.1  36968360-36968492
            1084-1291           JAXUCZ010000018.1  36969985-36970192
            1292-1457           JAXUCZ010000018.1  36974103-36974268
            1458-1591           JAXUCZ010000018.1  36974795-36974928
            1592-2215           JAXUCZ010000018.1  36975105-36975728
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2215
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="myotilin"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
     exon            1..85
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="upstream in-frame stop codon"
     exon            86..623
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1764
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="isoform 2 is encoded by transcript variant 3; titin
                     immunoglobulin domain protein (myotilin)"
                     /codon_start=1
                     /product="myotilin isoform 2"
                     /protein_id="NP_001424334.1"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
                     /translation="MFNYERPKHFIQSQNPCGSGLQPPGPEVSSFPNQTKQSSIVIQP
                     RQCTEQRFSASSTVSSHITVSSSAYPASQQLAGPNPGQKVTATYNQSPASFLSSILPS
                     QPDYSNSKIPSTVDSNYQQSSVHQPVNAVSSQAAGAKPTPRTPDHEIQGSKEALIQDL
                     ERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDVQDSSQQHNPEHAR
                     LQVPTSQVRSRSSSRADANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLP
                     APDVSWYLNGRLVQSDELHKMIVSEKGFHSLIFEVVRASDAGPYACVARNRAGEATFT
                     VQLDVLAKEHKRAPMFIYKPQSKKVFEGESVKLECQISAIPPPKLFWKRNNEMVQFNT
                     DRISLYHDNAGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTPPAP
                     KQLRVRPTFSKYLALNGKGLDVKQAFNPEGEFQRLAAQSGLYESEEL"
     misc_feature    1015..1287
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1015..1287
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1066..1080
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409405"
     misc_feature    1066..1080
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409405"
     misc_feature    1105..1119
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409405"
     misc_feature    1105..1119
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409405"
     misc_feature    1183..1197
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409405"
     misc_feature    1183..1197
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409405"
     misc_feature    1225..1242
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409405"
     misc_feature    1225..1242
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409405"
     misc_feature    1264..1275
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409405"
     misc_feature    1264..1275
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409405"
     misc_feature    1312..1587
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1312..1587
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1312..1323
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1312..1323
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1330..1347
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1330..1347
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1360..1383
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1360..1383
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1402..1422
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1402..1422
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1423..1434
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1423..1434
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1453..1473
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1453..1473
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1480..1512
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1480..1512
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1522..1548
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1522..1548
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1552..1587
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     misc_feature    1552..1587
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     exon            624..798
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            799..900
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            901..950
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1083
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1291
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1457
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1591
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2215
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccacac gatcctgagc aaggagatgc ttcttccttc tcttcagtag tgggttgaga
       61 caagctggcc ccttctgagc taaggaaaca atatccttca agagaaaccc accaacatca
      121 ggagtacagt gttctagaga tctcagcaag gagggccaga ctaaggtttc ttctgacttg
      181 ctgcaacctt ctgtaattcc aggcttgcca ccccacggtc aggagtctat ccttctggga
      241 gcaaatccat cttccatata ccagctaagc atgtttaact acgaacgtcc aaaacacttc
      301 atccagtccc aaaatccatg tggctccggg ctgcagcctc caggacctga agtctccagc
      361 ttccctaacc agaccaaaca gtcttccatc gtcatccagc ctcgccaatg caccgagcag
      421 agattttctg cttcctccac agtgagctct cacatcaccg tgtcttcctc tgcttatcct
      481 gcttcccagc agctggctgg ccccaacccc ggtcagaagg ttactgctac ctataaccag
      541 tccccagcca gcttcctcag ttctatatta ccgtctcagc ctgattacag taacagtaaa
      601 atcccatcca ctgtggactc caactatcaa caatcctcag ttcaccaacc tgtaaatgcc
      661 gtgtcatccc aagctgcagg tgctaagccc actccaagga ctcctgacca cgaaatccaa
      721 ggatcaaaag aagcattgat tcaagatttg gaaagaaagc tgaaatgcaa agacaccctt
      781 cttcataatg gaaaccaaag actgacctat gaggagaaga tggctcgcag gttgttagga
      841 ccgcagaatg ctgctgctgt gtttcaagct caaaacagtg acgtccaaga ttcgtcacag
      901 cagcataacc cagaacatgc acggctgcaa gttcccacat cacaagtaag aagtagatcg
      961 tcctccagag cagacgcaaa tgaccaggat gccatccagg agaagtttta cccaccacgc
     1021 ttcattcaag tgccagaaaa tatgtccatc gaagaaggaa gattctgcag aatggacttt
     1081 aaagtgagtg gactgccagc ccctgatgtg tcatggtatc taaacgggag actggtgcaa
     1141 tcagatgagt tgcacaaaat gatagtgtca gagaagggtt tccactccct catctttgaa
     1201 gtggtcagag catcagatgc agggccatat gcatgtgtag ccagaaacag agctggagaa
     1261 gccaccttca cagtgcagct ggatgttctg gcaaaagagc acaaaagagc accgatgttt
     1321 atctacaaac cacagagcaa aaaggttttt gagggagaat cagtgaagtt agagtgccag
     1381 atctcagcta tccctccacc aaagcttttc tggaaaagaa acaacgaaat ggttcagttc
     1441 aacactgacc ggataagctt atatcatgat aatgctggaa gagtaacttt actgataaaa
     1501 gatgtaaaca agaaggatgc tgggtggtat acagtgtcag cagtcaatga agctggcgtg
     1561 accacgtgta acacaagatt agatgtcaca gcccgtccaa accaaactcc cccagctcct
     1621 aagcaactgc gtgttcgacc aactttcagc aaatatttag ccctaaatgg gaaaggtttg
     1681 gatgtgaaac aagctttcaa ccctgaagga gagtttcagc gtctggcagc tcaatccgga
     1741 ctctatgaaa gtgaagaact ttaataactt tgcccacagg gaaaacagag cttcactcct
     1801 ccaatggatc tgataacatt gtgaaaaaaa atccatggtt gtattaacag attgtgactt
     1861 tacttaggtc atatactaac tcccatttag aatgttattc accctctgac tctggcacaa
     1921 cgtgtctatt cctctgacct gtgaagccgg cagtaaacta agtaaatgag tttgtattat
     1981 aagagactgt tttaagatac agtgtcttaa cactgaagtc atgcacattt aacaactatg
     2041 agttatgaac cagaaacttt ttaaatgcca ctaattcttg cagtaaagtg tatgggtatt
     2101 gcctaacaga ctttatttac ctgttttctc ttataggaat actaacatgg tatagattat
     2161 ctgagtgttc cacaatttca tgtcaaaaga gaataaaatt caagtagtta agaca
//
LOCUS       NM_001077667            1422 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 68 (Ccdc68),
            transcript variant 1, mRNA.
ACCESSION   NM_001077667 XM_001068607 XM_225849
VERSION     NM_001077667.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001077667.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000018.1  65817263-65817401
            140-268             JAXUCZ010000018.1  65830762-65830890
            269-355             JAXUCZ010000018.1  65832026-65832112
            356-490             JAXUCZ010000018.1  65837996-65838130
            491-616             JAXUCZ010000018.1  65840508-65840633
            617-745             JAXUCZ010000018.1  65841071-65841199
            746-829             JAXUCZ010000018.1  65853741-65853824
            830-906             JAXUCZ010000018.1  65856970-65857046
            907-1422            JAXUCZ010000018.1  65859014-65859529
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1422
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="coiled-coil domain containing 68"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
     exon            1..139
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    77..79
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="upstream in-frame stop codon"
     exon            140..268
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..964
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="isoform 1 is encoded by transcript variant 1; CTCL
                     tumor antigen se57-1; coiled-coil domain-containing
                     protein 68"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 68 isoform
                     1"
                     /protein_id="NP_001071135.1"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
                     /translation="MTTVTVTMEVPSGGKTEDRSIFSGPSSAQIIEETEYVRKIRTTL
                     EKIRNRMFKEEDGRGNARHKVDAEQSGNVQNGLDSTTDPTRLDLLLESMRRKDQQLLE
                     MNKENEVLQIKLEASREAGAAALRNAAQRLFDNYQTQSEDLEKKHKDSKHVLQVNKLE
                     KEQTLKQRAKNLSQLSEKLGEKHEQIVGLENRVQRMENMEGLKNTLKEQDKKIENLKE
                     KVTVLEAQNEELKTKVAHWTESPRTSVSKAVSTSELKTEGASPYLMLIRLRK"
     misc_feature    404..>856
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    404..>856
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            269..355
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            356..490
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            491..616
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            617..745
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            746..829
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            830..906
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1422
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgggaca ctggactctg ccctgggcgc gcctatctga gcacttaggt gctctcagtc
       61 gccaaacttc agcagttaag gacccgacgg tgggctctct gccagatcgc tggaactgga
      121 gcaggcggag gccttcaagc cagaattcac catgacaact gtcacggtga ccatggaagt
      181 tccttctggg ggtaagacag aagaccgctc catcttcagt ggaccgtcgt cagctcagat
      241 tattgaagaa actgagtatg tgagaaagat tcgaactacc ctggaaaaga tccggaatcg
      301 catgtttaag gaggaagacg gccgaggcaa tgcaaggcac aaagtagatg cagagcaatc
      361 tggaaatgtt cagaatggct tggattctac aacagacccc accaggttgg atttgctctt
      421 ggaaagcatg agaagaaaag atcagcagct cctagaaatg aacaaagaaa acgaagtgtt
      481 gcaaatcaag ctggaagctt cccgagaagc aggagcggca gctttgagaa atgcggctca
      541 gagattattt gacaactacc aaacgcagtc tgaagacctg gagaaaaagc ataaggacag
      601 taaacatgta cttcaggtca acaaactcga gaaagagcag acgttaaagc aacgtgccaa
      661 aaatctgagt caactttcag aaaaactggg agaaaaacat gagcaaatcg taggactgga
      721 aaaccgtgtc cagaggatgg aaaatatgga aggactaaaa aatactttaa aggaacaaga
      781 taaaaaaatt gaaaatttga aagaaaaggt caccgtgctc gaagcccaga atgaagaact
      841 aaaaaccaag gtggcacact ggacggaatc tcctaggaca tcagtatcta aggccgtctc
      901 tacaagtgag ttgaagactg aaggtgcttc tccctatttg atgttgattc ggctacgaaa
      961 atgagctggc tggctgcagt tctgacagag aaggacttct acagatttta tttattcctt
     1021 gaaatacagt ttcagctccc aagttaaagt gacatcatgt cttatctaaa tgtaacttag
     1081 tatacatcaa taacggcata gaaaggtgat attgcaggca attcaacaaa tgtctcctgg
     1141 agagaagaaa cctttttctt tttaaaccaa aatgtaactt aaaaggccaa gggactagga
     1201 tctttcccac atggaagatg aattctgctt taaacctaaa atattaaaat ttgaatctat
     1261 ctctcttcaa acattttaca aagaggactc ttataaggtt gtcagatttg acctttgata
     1321 gtggttctta tgtgtataaa taaagggaag tatgtaaata tatattaatg aatgatgtaa
     1381 tttaatttgg catttaggta ataaatatct taccatgcca ca
//
LOCUS       NM_001437401            3292 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 5, mRNA.
ACCESSION   NM_001437401 XM_039096703
VERSION     NM_001437401.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3292)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 3292)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 3292)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 3292)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096703.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77201.1,
                                           SRR26360181.297594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000018.1  41067362-41067420   c
            60-155              JAXUCZ010000018.1  41065895-41065990   c
            156-409             JAXUCZ010000018.1  41061600-41061853   c
            410-534             JAXUCZ010000018.1  41061277-41061401   c
            535-825             JAXUCZ010000018.1  41059874-41060164   c
            826-1123            JAXUCZ010000018.1  41049807-41050104   c
            1124-3292           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..3292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3292
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..59
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    48..50
                     /gene="Trim36"
                     /note="upstream in-frame stop codon"
     exon            60..155
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1478
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 5;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 5"
                     /protein_id="NP_001424330.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLR
                     LDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFR
                     PAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDK
                     ADSYVLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSR
                     ELVLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTS
                     LDYIIGDVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSG
                     HDSGSEDAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKG
                     KVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV"
     misc_feature    <144..428
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    <144..428
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    363..509
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    363..509
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    579..770
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    579..770
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    834..1445
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     misc_feature    834..1445
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     exon            156..409
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            410..534
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            535..825
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1123
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..3292
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctaggc ttgtcatttg gcttgcagtg tgatgtgaaa tactccctaa ccctggaggg
       61 agaaactttc aaaagacatt gatttcctta ttggtaagga aagccaggtg aagagtcaaa
      121 tttctgaact aaacttgtta atgaaagaaa cagagtgcaa tggagagagg gcgaaggaag
      181 aagcgctggc acattttgag aagctctttg aaatcctgga agacaggaag tcgtctgttc
      241 tgaaagccat agatgcctct aagaaactaa gactagataa atttcacact caaatggaag
      301 agtaccaagg ccttctagag aataacgggc ttgtgggata tgctcaggaa gtgctgaagg
      361 agacggatca gtcttgcttt gtgcagacag caaagcagct ccatctcaga atacagaaag
      421 ctacagaatc cctgaagagc tttagacctg cagcccaggc ttcttttgaa gactatgttg
      481 ttaacatttc gaaacaaaca gaggtgcttg gagaattgtc ctttttctct agtggcatag
      541 acattcctga gatcaacgag gaacagagta aagtgtataa taatgccctg atagactggc
      601 accatccaga aaaggacaaa gccgacagct atgttctcga ataccgcaag attaatagag
      661 acgaagaaat gatatcctgg aatgagatag aagttcatgg cacaagtaaa gttgtctcca
      721 atcttgaaag caacagtccc tatgcgttcc gagtgagagc ttacaggggt tctatctgca
      781 gtccctgcag tcgagaactg gttctgcata ctcctccagc tccagttttc agtttcctgt
      841 ttgatgaaaa gtgtggctac aatactgagc atctcttgct gaacctgaag agagaccggg
      901 tagaaagcag agctggattt aatgtcctcc tcgctgcgga acgcatccaa gtgggccatt
      961 acacaagctt agactacatc atcggggatg tcggaatcac gaaaggtaaa cacttctggg
     1021 cctgccgtgt ggaaccgtat tcatacctgg tgaaagtggg agttgcttcc agtgacaaac
     1081 tgcaagagtg gctgcgctct ccccgggacg cagctagtcc aagatatgag caagacagtg
     1141 ggcatgacag cggaagtgag gacgcctatt ttgattcttc acaaccgttt acattagtta
     1201 ctataggcat gaagaaattt tttataccca agtcacctac ttcttctaat gaacccgaaa
     1261 acagagttct ccccatgcca acaagtatag ggattttcct tgactgtgat aaaggcaaag
     1321 tgagcttcta tgatatggac cacatgaaat gcctatatga gcgccaggtg gactgttcac
     1381 acacaatgta ccccgctttt gcgttaatgg gcagtggcgg gatccagctt gaggaaacca
     1441 tcaccgcgaa gtatctggaa tatgaagagg atgtgtagct tggacacccc acaggacgag
     1501 gatcagaact gtgaacaaag ccatgccgtg gtgttagagt cttcgtaact aattacatat
     1561 catttacgtc tctgtcacca cacctgtttg tactgtgtga ttctttgttt tgttttgttc
     1621 tgctttgaca cacacagtct cagtgtgtag tccaggccag cttcaaactc tgttctgtta
     1681 tagcctcctt aggggctggg attataggca ggcaccacca tacccagcta gtgtatgatt
     1741 cacaactttt ttcatgtcat aatggtctta ccttttacaa atggtgggag tagagacttg
     1801 tcttaactgg tccaggatag ataactctac aatggaagtc cttctctttg gggacaagga
     1861 ctctaattga tgtaagtcag ctgatggtgg tattattcct gtccctttgt ttgggggttg
     1921 cagtgggata caaagtattt acaaagttct ttgtgcttgt tttcttcttt ccttttcatt
     1981 gtgtatcatg ttcatgtcca aagagaagat atttttaaat gtttatcgat agaaattagt
     2041 actaagccat gtgtcttgca tttgatgtta ataggaaaat aaatttacag ataggtaaaa
     2101 tgatgaaggc cataaaatgg tagtatattt aagtagaaaa ttatgtattt taaagtgtgt
     2161 aactactgag tgtatattgc ctggcaaacg aatactgctt tttccctcta tagaccacag
     2221 actgtattgg taagaatatc tctaagagtg tctttgctgt agtgcccatt gtcctgtaca
     2281 tgtagcaagc atcgtttcat ataagaaaca cagggttctt gaacccatgc gactttccac
     2341 tacaatagaa ttctttttca ggaaatttta ttttcaaatt ttcttatttt agaaaatact
     2401 catttatagc aaagaattat ttttcagaaa tactagggaa gatggactga tagtgaacac
     2461 ctatcttttt gtgtcttgtg aactttatga ttttggtaca tatgttatac atcagggttt
     2521 tctggctttt gtttacagat ttgagaagtt tgctgtccat tttcagcgtt gttgaatgcc
     2581 agacatgtta catgttacta ctgtccactt ggatggcact gtttgtgggc tcattgtgtg
     2641 gtcataagca tttgtagtgt gaatcagtaa aatacaaaat tccttagaca taatagctaa
     2701 acatcacaag gatgtgtcta gtcagttttt acaccttttc tacactagat gttaatttct
     2761 gcaaggttac tttccaatta tttgaattgc ctttttaaaa gttaaaatgt ccagacacta
     2821 agacttacat gtgttcagca ctgatcatgc aatggaatgg tagcattttg gtagaataac
     2881 caaagctgtt tatttgattg attcttttta atggaagcct gttgggctaa tcacactgca
     2941 tctgacccag cactgactgg tacgcatccc tacgcttgtg tagaaatatc tggaggattt
     3001 gtgtttagtg attgcccttc ctctcccact tatatctagc actttatgac ataggaaaca
     3061 gagagaatgt gcagtgttac ctggggtcat tgtgcaataa tgctgctaaa gtcgccgcac
     3121 gtgtgggtta gtgtgacact caatattcat gtaagcacat gtcctgtaga cattttaaaa
     3181 tataaagctt taactggagt cagagaagcg agctgttcga acactgtatc actgtataga
     3241 aattgcttag tggaattcca cttttttaaa ataaaaaaat aaataaaggg aa
//
LOCUS       NM_001437303             819 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 10, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001437303
VERSION     NM_001437303.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 819)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 819)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1175280.1,
                                           SRR26360176.372334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-286             JAXUCZ010000011.1  44823308-44823443
            287-819             JAXUCZ010000011.1  44825271-44825803
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..819
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            151..286
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..413
                     /gene="Mrps6"
                     /note="isoform 5 is encoded by transcript variant 10; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 5"
                     /protein_id="NP_001424232.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGDSARTSLFVGE
                     GLMESHIAEGATGGGVLSTLSKKGEHLPEA"
     misc_feature    <189..>284
                     /gene="Mrps6"
                     /note="Bacterial ribosomal protein S6; Region: bS6;
                     cl00414"
                     /db_xref="CDD:469763"
     misc_feature    <189..>284
                     /gene="Mrps6"
                     /note="Bacterial ribosomal protein S6; Region: bS6;
                     cl00414"
                     /db_xref="CDD:469763"
     exon            287..819
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg agaccgctgc tgctttaaaa cgtacaatag
      181 aatccctgat ggaccgagga gccatagtga ggaacttgga aaacctgggt gagcgtgcac
      241 tcccatacag gatctccagt cacagccagc agcacagccg aggaggagac tcagcccgaa
      301 cctcactgtt tgttggagag ggtttaatgg agtcacacat tgcagaggga gcaacgggag
      361 gaggtgtttt gtcgactctt tctaaaaagg gcgagcatct ccctgaggcc tagtgatact
      421 ccactgcaca gcagccagcc tcactccagg actgcacacc gtttgaagct ctttgcacta
      481 ggtgctggag ggaggacagc aaaagaactg gtgatctctc agtgctgaac ttgtgtgtcc
      541 ggtggcctgt gactggccag gagactgggc tcacttccat gcttgtaaga actcttcagt
      601 tgggggctgg agagatggct cagaggttaa gagcactgtc tgctcttcca gaggtcctga
      661 gttcaattcc cagcaaccac atggtggctc acaaccatct atagtcaggt ctggtgccct
      721 cttctggcct gcagacatac atgcaggcag aaagctgtat gatgtataca taataaataa
      781 ataaatgtta aaaaaaaatc tttaaaaaaa aaaaaagaa
//
LOCUS       NM_001437316            4814 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), transcript
            variant 3, mRNA.
ACCESSION   NM_001437316 XM_039089366
VERSION     NM_001437316.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4814)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4814)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4814)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039089366.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2021162.1,
                                           SRR26643293.83815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000012.1  16568887-16569026
            141-276             JAXUCZ010000012.1  16579863-16579998
            277-407             JAXUCZ010000012.1  16584164-16584294
            408-1217            JAXUCZ010000012.1  16586457-16587266
            1218-1294           JAXUCZ010000012.1  16588652-16588728
            1295-1397           JAXUCZ010000012.1  16591172-16591274
            1398-1562           JAXUCZ010000012.1  16592806-16592970
            1563-1677           JAXUCZ010000012.1  16597507-16597621
            1678-1817           JAXUCZ010000012.1  16598234-16598373
            1818-1868           JAXUCZ010000012.1  16602723-16602773
            1869-2006           JAXUCZ010000012.1  16604251-16604388
            2007-2155           JAXUCZ010000012.1  16609121-16609269
            2156-2234           JAXUCZ010000012.1  16609681-16609759
            2235-2332           JAXUCZ010000012.1  16658476-16658573
            2333-2555           JAXUCZ010000012.1  16670103-16670325
            2556-2625           JAXUCZ010000012.1  16687074-16687143
            2626-4814           JAXUCZ010000012.1  16687679-16689867
FEATURES             Location/Qualifiers
     source          1..4814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4814
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..140
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            141..276
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..158
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="upstream in-frame stop codon"
     CDS             210..2942
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase RNF216"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216 isoform 1"
                     /protein_id="NP_001424245.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTETHKPQTSRPNLIKPAAEWQDLNRLGEERPRKSRADF
                     EADTHSYFSFCNNSLFDSGAQDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTVS
                     PRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEYW
                     LDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGP
                     ASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLVK
                     ETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQ
                     DDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITR
                     KAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHC
                     RSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGE
                     FPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQ
                     TILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQ
                     GLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRC
                     GAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEE
                     EQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPV
                     RPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     misc_feature    1881..2051
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1881..2051
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    2148..2303
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2148..2303
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2334..2504
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     misc_feature    2334..2504
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     exon            277..407
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            408..1217
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1294
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1397
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1562
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1677
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1817
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1868
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2006
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2155
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2234
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2332
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2555
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2625
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..4814
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtttgg gccccttgga gtccaagttg acgcctgtca tcccaatcag cgctccggag
       61 caaaagggac tcgaaactcc tgcagtcggg cgtcctggtg cgcggtggag agagcgctcc
      121 cgtggcgcgt ggcaccttgg accctacaga acagatgatc accatgtctg ggttctagca
      181 atcacatacg tttatatctg aatttgaaaa tggcagaggg aaacaaccaa gaggaggtca
      241 ttcacttgaa caactttcac tgccaccggg ggaaggagtg gatggctgtc agagaggggc
      301 ccatcaccat atctgactcc tctgatgagg aagggattcc aatgctggtt accccggcta
      361 ctgagcaaca ggaagacgac ctggatgatg atgtcatcct gacagaaaca cataaacctc
      421 agacatcccg gcccaatctc atcaaaccag ctgccgagtg gcaagatctg aacagattgg
      481 gagaagaaag gcctagaaaa tctagagcag actttgaagc agatacccac agctattttt
      541 ccttttgtaa caactcattg tttgattctg gggcacagga tgattctgag gatgaatgtg
      601 gtggatttct ggatcttaag actgagaaaa aaggaggaga agccaaacct ggaccaagca
      661 ataagcagac agcagacaat actgtcagcc ccaggctgga gcagaaagtc attattttgg
      721 gagaaaatgg tcttcttttt tcagaaagtg agcctctgga agttcagaac caattatctg
      781 aagactcaga gacagatctt ttatcaaatc ctggtgagcc agctgcctca gtagatgagc
      841 agctaattga agaagagtac tggcttgacc atccctactt ccaggctctg aatccacagc
      901 ctcaggagag aacaaaccag cttgtgcccc aagagcgaca ttctgaatca gaaatgggcc
      961 caatgttttt ccgccatgat ttcccggagc cagcttttcc aaggccagaa ccccagcagg
     1021 aggggattcc aggacccgct tctccacaac cagcccatcc tctaggagag cttgaagacc
     1081 agcaattagc aattgatgaa gaccctgggc ctgcctaccc cctgccagga ccccaggagg
     1141 ccaatttggc aaatgtgtgg ggacaagaag ctgctgaagg ggatcaagag ctcattccac
     1201 tgttagtgaa agaaacggaa gcaagatttc cagacgtagc aaatggatat gttgaagaga
     1261 taattcattt gaaaaattac tatgatttga atgtactttg taattttctc ctggaaaatc
     1321 cagattatcc aaagagagaa gaccgaatcc ttatccaccc cagcagtagc ctgcttgcca
     1381 gccaggatga tgtgaagttg cctaagatag acttttttga ctattccaaa ttgactccac
     1441 ttgaccagcg ctgcttcatc caagctgctg acctcttgat ggctgatttc aagatgctca
     1501 gcagccagga catcaagtgg gccctgcacg agctcaaagg gcattacgca atcacccgaa
     1561 aggccttttc tgatgccatt aaaaaatggc aggagctatc acctgaaacc agtggaaagc
     1621 ggaaaaagag gaaagaaatg aatcagtatt ctttcataga cttcaaattt gaacaaggta
     1681 acataaaaat agaaaagagg atgttctttc tggaaaacaa gcgtcgacac tgtaggtcct
     1741 atgaccagca ggccctcctt ccagctgtgc agcaagagca ggagttctat gagcagaaaa
     1801 ttaaagagat ggcagagcac gaagattttt tgcttgccct gcagatgaat gaagagcagt
     1861 atcaaaagga tggccagctg attgaatgcc gctgctgcta tggggagttt ccatttgagg
     1921 agctgacaca atgcgctgat gctcacttgt tctgcaaaga atgtctcatc agatatgccc
     1981 aagaggccgt gtttggatct ggaaagtcag agctcagctg catggaaggc agctgcacat
     2041 gttccttccc aaccagtgaa ctggagaaag tgctccccca gaccattctg tacaaatact
     2101 atgaacggaa agctgaagag gaagtcgcag cagcctatgc tgacgagctt gtccggtgcc
     2161 cctcttgcag cttccctgct ctgttggaca gcgatgtgaa gaggttcagc tgccctaacc
     2221 ctcgctgccg aaaggagacc tgtaggaagt gtcagggact ctggaaagaa cacaatggcc
     2281 tcacctgtga agagctggca gaaaaggatg acatcaagta ccggacatct attgaagaaa
     2341 aaatgactgc tgctcgaatt agaaaatgcc acaagtgtgg gactggcctc atcaaatctg
     2401 aaggctgcaa ccgcatgtct tgccgctgtg gtgcccagat gtgctacctc tgtcgagttt
     2461 ctatcaatgg ctatgaccac ttctgccagc atcctcgctc tccaggagcc ccttgccagg
     2521 aatgttccag gtgctccctc tggaccgacc ccactgaaga tgatgagaag ctgattgagg
     2581 agatccaaaa ggaggctgag gaggagcaga aaagaaagaa tggagagaac actttcaaac
     2641 gcatcgggcc cccactggag aagccggctg agaaagtgca gcgtgtggaa gccctgccac
     2701 ggcctgtccc acagaacctg caccctcaga tgccacccta tgcctttgtc cacccaccct
     2761 tccccctgcc acctgtgcgg cccgtgttca acaacttccc catcaacatg ggtcctgtgc
     2821 ccgcacccta tgtaccccct ctgcccaacg tgcgtgtcaa cttcgacttt ggccacgtgc
     2881 atgtgcccct ggagcacaac ctgcccatgc actttggccc ccaaccacgg catcgcttct
     2941 gacacccaaa gccctgtcca gctgtgctga gtctgcagga ggacccagtc tcatcctctg
     3001 agtagggatg aagtcctcga ctccctatgg ggtgtgggct cgtgtcctcc tgctcttccc
     3061 gttgcgaggt ccactgctcc ttcgggtctg atgcgccttg ggtgctgact gtcgctgcac
     3121 cagtaatagg gcagctcccc gggtctgcca tctatcttag cagccagtcc aggggccttg
     3181 gccgagaagc aggcccttta agcatttgcc atacttcctc cccagcagac cactgaaagc
     3241 ccaagggaaa atggcctacc ctccccaggc cagggctctc tccttgttgc ccaaggccca
     3301 ctcaggtcca agggccgcca agaatcttct gtggcgcaag ttttgttctg ttgttaccta
     3361 gaggttgctc ctattcacat agtttgagct gaagtttttt gtgtgtcccc atccgtggaa
     3421 agtcaggttg aaggtatttc cccagggctg gcaactgctg agaaccagta gtcctgacac
     3481 ttgacatcaa acagaaggac ccttttaggg ccctttattc ctgggctgcc ccttttctgg
     3541 gagagacctc acttgtcacc aacctgggat gagcagcatc tctcctaagg tttttagggg
     3601 cttccctagc agtgcagatg acctcatgga gctgctgcag ctatcacagc aaccctcctg
     3661 cccgctcagc tgtccctcac tagttagcag tggatgcaga caggagaggt ctagctccaa
     3721 gatgaggaca gctggcttcc ctagagtcag atgaaaatcg gcctgcacag tctttgccat
     3781 gttcccacta cctgtgtccc ctcctgtcca gaccagatct ttatactctc ctccagtgtg
     3841 tgttgaccag ggctgatagc aagtgtctca ctcagttgta ctggctgtcc ttgtcgtgga
     3901 gtgtcccatg ttcagagtgt acagacttag aagagagaag atgtccctgg gaaaaggaaa
     3961 gactccctga ggtgcccact gtcactggag tgtgggtagg gcacacaggg caactcagga
     4021 gccctgccat gggtcacctg aactgtgatg ctagtctgaa tgacagtgcc ttggaaagat
     4081 gggccacatg ctgcatgaca ggatcctcca agtaccttaa caattagtgt actcgtgttc
     4141 tctgcacttc tccagaagcc ctgcaggggg cggtactccg agcactgccc ctccaaggcc
     4201 tcatgagccg ctggactggg cacccagttc tgggcgcctc agtaccctat cacattgttc
     4261 caccaagagg ccagatggaa aaactggcag tttctggggt agctggaaga gcaggccagg
     4321 caggtgccat ccagaccctg gcactccatt tggagaggtg aggccagaga cgtatccttc
     4381 aaaatattgt cagtctgtga cagggagact gctactgcct gtctccatca aggagtgacc
     4441 ctcccatgtt gccagcaggg ctagggagtg aggggtgggc cagcaaggat ccccaaggca
     4501 gctgccacct taacccctag gacccagact gcttcctggt ttaagaaact gcctagccac
     4561 tcccagtgta tttgccttaa aactggagag aatctagtat ttgcacttag caaaagattt
     4621 caaagttaag agaaaagtgc atgatctcac tttgtacaaa agaaaaaaag gaaaaaaaat
     4681 gaagtagatg gttaaacgtt tttctttacc ttttggtagt aaaaatagag aaaacaagtc
     4741 tgtttaaact actgtgtaaa aagactgtat catatgtaac ttgaattttg tgtaaataaa
     4801 tgtttgtgaa cgct
//
LOCUS       NM_001437230            1533 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 9 open reading frame
            153 (C17h9orf153), transcript variant 1, mRNA.
ACCESSION   NM_001437230 XM_063276008
VERSION     NM_001437230.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063276008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.70561.1,
                                           SRR26360181.1898673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000017.1  4980936-4980957
            23-205              JAXUCZ010000017.1  4981452-4981634
            206-301             JAXUCZ010000017.1  4985033-4985128
            302-791             JAXUCZ010000017.1  4986300-4986789
            792-1533            JAXUCZ010000017.1  4987547-4988288
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1533
                     /gene="C17h9orf153"
                     /note="similar to human chromosome 9 open reading frame
                     153"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
     exon            1..22
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            23..205
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="C17h9orf153"
                     /note="upstream in-frame stop codon"
     exon            206..301
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1039
                     /gene="C17h9orf153"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C9orf153 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153 homolog isoform
                     1"
                     /protein_id="NP_001424159.1"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
                     /translation="MSSTRHHTWTRGSIGSLYLHRCSLPELYASLEIFNKESKKSNLQ
                     KICGMSFKEAQEVLWKILGGLISDSYDTVKGDERHPSIPVNKEERKTPSMSDLLHQSL
                     LKGYNVPLEQVHSSQQRLAQVGIPPPPLSFPHGLSNELPVILPAQHFRKRIQSVTFRK
                     LLLSSVAPGRLFYEEKPTSQQVSFDPGKQFLDLADLQWRYFKGLAKWGKMPRRFSLLN
                     IEYNSEKRYVENQRMSGLIFPPLVRKTLMVYPQAEYDKEGQLYLTWKIVY"
     misc_feature    233..508
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     misc_feature    233..508
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     exon            302..791
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1533
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgagcct gcggtctacc agagctagtg ctcatgagaa agctacctcc tttgaaccat
       61 gatggaatat gatttgtgaa caatgaaaag atgtgtaagg tcaaactggg ttccaaccta
      121 cgctgctggg atgaactctc cctgccacag cgggcctggc aatccttaag gacaccaccc
      181 atccaaccaa gacgtcccta agcaggaacg tggaggttca gatcttggca caatgtcctc
      241 caccagacac cacacttgga cccgaggcag cataggatcc ctgtatctgc accgttgttc
      301 gctaccagaa ttatatgcat cacttgagat ttttaataag gagagcaaga aatctaatct
      361 ccaaaagatc tgtggcatgt cgtttaagga agctcaggaa gtcctttgga aaatcctggg
      421 tggcctgatc tctgacagct atgacaccgt aaaaggggat gagcgccacc cttccatacc
      481 ggttaacaaa gaggagcgga agacaccatc tatgtcagat ctacttcacc aaagtctgtt
      541 aaagggttac aatgttccgt tggagcaggt acacagctcc cagcagaggc tggcccaggt
      601 gggcatccct cctcctccac tctcctttcc tcacggttta agcaacgaac tgcccgtgat
      661 ccttccagca cagcacttca ggaaaaggat tcaaagcgtc acattccgca aacttctcct
      721 gtcttctgtt gccccaggca ggctgttcta tgaagaaaag ccaacaagcc aacaagtctc
      781 ctttgaccca ggaaagcagt tcctagacct ggcagacctt cagtggaggt atttcaaggg
      841 acttgcaaag tgggggaaaa tgcccaggag gttttccctc ttgaacatag aatacaacag
      901 tgagaagaga tacgtagaga accaacgtat gtctggactc atcttccctc ccctagttcg
      961 caagactctg atggtctacc ctcaagctga gtatgataaa gaaggacagc tttatctcac
     1021 ctggaaaata gtgtactgaa atagtctgga tatgaaccgt tctgcttggg attgccgaac
     1081 caacacaaga ggtggaaaag cacacagccc acttctctac tcaatgtccg tgcaaagcct
     1141 acattaaaat gatttcgtgg aggaacatgt ccaaccaatc tgctggcatt actctggttc
     1201 acagttctga tgctcatctg aacagcaggt gaagggaata ctgggtggat acacagaaat
     1261 agctctccac caaaaatgga tctctacaat gttttcttcc ttggtttctc tgtttctttg
     1321 tttctggttt gtttatttgt ttgtttgttt gtttactttt tgctgtcaat atgtaattta
     1381 cttacttaaa aaaatccaaa ttctggcatt gtctagaaaa tttcagtagg ttttaaagtt
     1441 gaactgttga aatgtgttca cggaagcatt ctgcttgcat taatgcttta cacggtgcat
     1501 gtatattaaa agtcacaccc aaatgaacgt gga
//
LOCUS       NM_001437424            2122 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus polo-like kinase 5 (Plk5), transcript variant 1,
            mRNA.
ACCESSION   NM_001437424 XM_006240921
VERSION     NM_001437424.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006240921.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38032.1,
                                           SRR26643292.28401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000007.1  10005661-10005843   c
            184-291             JAXUCZ010000007.1  10004242-10004349   c
            292-408             JAXUCZ010000007.1  10003992-10004108   c
            409-538             JAXUCZ010000007.1  10003456-10003585   c
            539-626             JAXUCZ010000007.1  10002630-10002717   c
            627-722             JAXUCZ010000007.1  10002452-10002547   c
            723-921             JAXUCZ010000007.1  10001658-10001856   c
            922-1048            JAXUCZ010000007.1  10001445-10001571   c
            1049-1125           JAXUCZ010000007.1  10001180-10001256   c
            1126-1198           JAXUCZ010000007.1  10000771-10000843   c
            1199-1333           JAXUCZ010000007.1  10000436-10000570   c
            1334-1490           JAXUCZ010000007.1  9999984-10000140    c
            1491-1620           JAXUCZ010000007.1  9998944-9999073     c
            1621-1731           JAXUCZ010000007.1  9998755-9998865     c
            1732-2122           JAXUCZ010000007.1  9997453-9997843     c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2122
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polo-like kinase 5"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
     exon            1..183
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1923
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /EC_number="2.7.11.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polo-like kinase 5 pseudogene; serine/threonine-protein
                     kinase PLK5; inactive serine/threonine-protein kinase
                     PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5
                     isoform 1"
                     /protein_id="NP_001424353.1"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
                     /translation="MEPRLRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLHHRNIVAFHAHFADRDHVYM
                     VLEYCSRQSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYLHQQRIVHRDLKPSNFFLNK
                     NMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSAKSDIWALGCIMYTV
                     LTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIARLLAPDPDERPSLDHLLQD
                     DFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQLLLTQCRPPCPFTSKEASGP
                     GEESTEPDHMEASNEEGAPLCTESRIHLLTLGTPRTDPADAKGTLALQLEVATRKLCL
                     CLDAGPVGRTATPKCRTEAAWRGPKPAGQDPPGEQRSVLWAPKWVDYSLKYGFGYQLS
                     DGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGPLRAKLAVLRLFACYM
                     QRRLREEGTAPMTATPASPDFCLLSFTADAQALAMLFSNGTVQVSSKTSPVQLVLSGE
                     GEDFLLTIQEPGGPSMGTSYTLDVLRSHGISLAVRHHLRLGLHLLQSV"
     misc_feature    151..915
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Polo-like kinases; Region: STKc_PLK; cd14099"
                     /db_xref="CDD:271001"
     misc_feature    151..915
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Polo-like kinases; Region: STKc_PLK; cd14099"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     388..399,409..411,415..417,526..528,532..534,538..543,
                     547..549,580..582,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="active site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     388..399,409..411,415..417,526..528,532..534,538..543,
                     547..549,580..582,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="active site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     391..399,547..549,580..582)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     391..399,547..549,580..582)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(187..189,409..411,415..417,526..528,532..534,
                     538..540,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(187..189,409..411,415..417,526..528,532..534,
                     538..540,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(577..603,616..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271001"
     misc_feature    order(577..603,616..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271001"
     misc_feature    1363..1626
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    1363..1626
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    order(1381..1392,1597..1599,1603..1617)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     misc_feature    order(1381..1392,1597..1599,1603..1617)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     exon            184..291
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            292..408
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            409..538
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            539..626
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            627..722
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            723..921
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1048
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1125
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1198
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1333
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1490
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1620
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1731
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..2122
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcggcag cgctgcaggc agcactggct tgcccagttc ccgcgcgcgc gctgcgcacc
       61 caggcccacc ccgcgtcgat ggagccccgg ttgaggcggc ggcgaagccg ccagctagtg
      121 gccaccttcc tgcgtgaccc gggctcaggg cgcgtgtacc ggcgcgggaa gctgatcggc
      181 aagggcgcct tcagccgctg ctacaagctc acggacatgt ccaccagcgc ggtgtttgct
      241 cttaaggtgg tgccgagggg cggagcgggg cggctgcgcc tgcgcgggaa ggtggagcgt
      301 gagatcgccc tgcacagccg cctgcaccac cgcaacatcg tggccttcca cgcacacttt
      361 gctgaccgcg accacgtgta tatggtgctg gagtactgta gccgccagtc cttggctcat
      421 gtactgaaag tgcggcggac cctgacggag cctgaagtgc gctactactt tcggggcctg
      481 gtcagtggcc tccgctacct gcaccaacaa cgcatcgtgc acagggacct gaaacccagt
      541 aatttcttcc ttaacaagaa catggaagtt aagataggtg acctggggct ggctgcccgt
      601 gtggggcccg ctggccgctg ccacagggtg ctctgtggga ctccgaactt ccaggctcct
      661 gaagtggtgt cccgaaatgg acactcggcc aagtctgaca tctgggccct ggggtgcatt
      721 atgtacacgg tgctgacggg cacgcccccc ttcgctgccg cacccttgtc cgagatgtac
      781 caaaacatcc gagacggtca ctaccttgag cccactcagc tgtcacccag cgcccgtagc
      841 ctcattgcac gacttctggc accggaccct gatgagcggc ccagcctgga ccacttactg
      901 caagatgact tttttagtca gggctttacc ccagagcggc tgcctccaca ttcctgccac
      961 agcccacccg tgtttgcctt ccccccgcca ctgggcaggt tgttccggaa ggtgggccaa
     1021 ctcctgctga cccagtgccg gccgccctgt ccctttacct caaaagaggc ctcaggcccg
     1081 ggagaagaga gtacagaacc tgaccacatg gaggccagca acgaggaagg ggctcctctc
     1141 tgcactgaga gccgaatcca cctcctcact cttggaaccc ctcggactga cccggccgat
     1201 gcgaagggga ccttggccct gcagctggag gtggcaacca gaaaactgtg cctctgcttg
     1261 gatgcaggac ctgtgggtag gacggccacc ccaaagtgca ggactgaggc agcctggagg
     1321 ggccctaaac cagctggaca ggaccccccc ggggagcagc gctctgtcct ctgggctccc
     1381 aagtgggtgg attattccct caagtatggc ttcggttacc agctgtcgga tgggggcagt
     1441 ggcgtgctgt ttcgggatgg ctcccacatg gccctgcgcc ccccaggagg ccatgtctcc
     1501 taccaacctg accaagggac tctgtggatc ttcgccctga gggacgtccc cggcccactc
     1561 cgcgccaagc tggccgtcct gaggctcttt gcctgctaca tgcagcggcg tctgcgggag
     1621 gaggggacag cacccatgac ggccacaccc gcctctcctg acttctgtct gctgagcttc
     1681 accgctgatg cccaagctct ggccatgctc tttagcaatg ggacagtgca ggtcagttcc
     1741 aaaacctccc cagtccagct ggtgctgagt ggggaaggcg aggactttct gctcaccatc
     1801 caggagccag ggggacccag catgggcacc tcctacacgc tggacgtcct gcggagtcac
     1861 ggcatcagcc ttgcggtccg ccaccacctg cgccttggac tgcatctgct tcagagtgtc
     1921 taaggagccg gacggagatc tgggcggacc tctgcgtgat ggtgctggtg tctgtttctg
     1981 tctgcgctcc tccgccacag ccagtgtctg tggagggtgg acacattggg acctctgatg
     2041 ggtgggcgtc tttgattatt tgactactca aggtagactt tttttggatt ttcattaaag
     2101 aaaacagaac cctttaaact gc
//
LOCUS       NM_001437334            6900 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol transfer protein,
            membrane-associated 2 (Pitpnm2), transcript variant 1, mRNA.
ACCESSION   NM_001437334 XM_063271303
VERSION     NM_001437334.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6900)
  AUTHORS   Lu,C., Vihtelic,T.S., Hyde,D.R. and Li,T.
  TITLE     A neuronal-specific mammalian homolog of the Drosophila retinal
            degeneration B gene with expression restricted to the retina and
            dentate gyrus
  JOURNAL   J Neurosci 19 (17), 7317-7325 (1999)
   PUBMED   10460238
REFERENCE   2  (bases 1 to 6900)
  AUTHORS   Lev,S., Hernandez,J., Martinez,R., Chen,A., Plowman,G. and
            Schlessinger,J.
  TITLE     Identification of a novel family of targets of PYK2 related to
            Drosophila retinal degeneration B (rdgB) protein
  JOURNAL   Mol Cell Biol 19 (3), 2278-2288 (1999)
   PUBMED   10022914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271303.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000012.1  38068526-38068766
            242-418             JAXUCZ010000012.1  38104755-38104931
            419-633             JAXUCZ010000012.1  38114915-38115129
            634-755             JAXUCZ010000012.1  38116367-38116488
            756-983             JAXUCZ010000012.1  38117712-38117939
            984-1283            JAXUCZ010000012.1  38121825-38122124
            1284-1379           JAXUCZ010000012.1  38122990-38123085
            1380-1484           JAXUCZ010000012.1  38124853-38124957
            1485-1555           JAXUCZ010000012.1  38125120-38125190
            1556-1803           JAXUCZ010000012.1  38127459-38127706
            1804-1993           JAXUCZ010000012.1  38128142-38128331
            1994-2113           JAXUCZ010000012.1  38128491-38128610
            2114-2352           JAXUCZ010000012.1  38129454-38129692
            2353-2531           JAXUCZ010000012.1  38130083-38130261
            2532-2702           JAXUCZ010000012.1  38131413-38131583
            2703-2867           JAXUCZ010000012.1  38133165-38133329
            2868-3029           JAXUCZ010000012.1  38133783-38133944
            3030-3178           JAXUCZ010000012.1  38134760-38134908
            3179-3295           JAXUCZ010000012.1  38135164-38135280
            3296-3412           JAXUCZ010000012.1  38135579-38135695
            3413-3561           JAXUCZ010000012.1  38135773-38135921
            3562-3711           JAXUCZ010000012.1  38136037-38136186
            3712-3895           JAXUCZ010000012.1  38136681-38136864
            3896-4024           JAXUCZ010000012.1  38136960-38137088
            4025-6900           JAXUCZ010000012.1  38137171-38140046
FEATURES             Location/Qualifiers
     source          1..6900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..6900
                     /gene="Pitpnm2"
                     /note="phosphatidylinositol transfer protein,
                     membrane-associated 2"
                     /db_xref="GeneID:304474"
                     /db_xref="RGD:1310867"
     exon            1..241
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..418
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    251..253
                     /gene="Pitpnm2"
                     /note="upstream in-frame stop codon"
     CDS             341..4348
                     /gene="Pitpnm2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-associated phosphatidylinositol transfer protein
                     2"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 2 isoform 1"
                     /protein_id="NP_001424263.1"
                     /db_xref="GeneID:304474"
                     /db_xref="RGD:1310867"
                     /translation="MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGQGSGVEILE
                     NRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCP
                     FVEKFSIDIETFYKTDTGENNNVFNLSPVEKNQLITDIIDIVKDPVTPSEYKTEEDPK
                     LFQSIKTRRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRR
                     VMVRAHRQAWCWQDEWYGLTMEKIRELEKEVQLMLSRKMAQFSEEGPSELSKESTIKD
                     QATGATPEPSSSNGESLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDS
                     DESSEEEFFDAQENLQHKEEMYTKDITKWSSNDLMDKMENPEPEESQDSLYHQSGSEF
                     RVASSVEQLNTIEDEVSQPLATPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTIT
                     NVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPL
                     AALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFD
                     ALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGILVNAAHCSGGSGGGSGGGSSLESS
                     RHLSRSNIDIPRSNGTEDSRKQMPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPS
                     SRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQ
                     VYNLFHPADPSASRLEPLLERRFHTLPPFNIPRYQRYPLGDGCSTLLADALQTHNTVF
                     QEHAAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASGIAQKGPSSLNHTPSIRR
                     LSLLALPPPSPTTQGPRARARQVSPNLERGPCLPDLDIGEVAAKWWGQKRIDYALYCP
                     DALMAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSASILELDGKEVSVFTPSQPR
                     EKWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVDVHIM
                     TQPPSGEWLYLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYITVLP
                     KGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQR
                     VVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDVAVYN
                     SISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMALRKG
                     SFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDLEQRGQRSMSMAASCWGR
                     AMAGRLEPGAATGPK"
     misc_feature    341..1114
                     /gene="Pitpnm2"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); Region:
                     SRPBCC_PITPNM1-2_like; cd08889"
                     /db_xref="CDD:176898"
     misc_feature    341..1114
                     /gene="Pitpnm2"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); Region:
                     SRPBCC_PITPNM1-2_like; cd08889"
                     /db_xref="CDD:176898"
     misc_feature    order(401..406,413..415,425..427,434..436,458..460,
                     515..517,521..523,527..529,533..535,542..544,548..550,
                     557..559,569..571,581..586,590..592,596..598,602..604,
                     608..610,623..625,629..631,635..637,644..649,665..667,
                     671..673,914..916,932..934,938..940,968..970,992..1000,
                     1007..1009)
                     /gene="Pitpnm2"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176898"
     misc_feature    order(401..406,413..415,425..427,434..436,458..460,
                     515..517,521..523,527..529,533..535,542..544,548..550,
                     557..559,569..571,581..586,590..592,596..598,602..604,
                     608..610,623..625,629..631,635..637,644..649,665..667,
                     671..673,914..916,932..934,938..940,968..970,992..1000,
                     1007..1009)
                     /gene="Pitpnm2"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176898"
     misc_feature    533..589
                     /gene="Pitpnm2"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    533..589
                     /gene="Pitpnm2"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    order(692..781,797..871,896..901)
                     /gene="Pitpnm2"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    order(692..781,797..871,896..901)
                     /gene="Pitpnm2"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    830..832
                     /gene="Pitpnm2"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]; other site"
                     /db_xref="CDD:176898"
     misc_feature    830..832
                     /gene="Pitpnm2"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]; other site"
                     /db_xref="CDD:176898"
     misc_feature    2441..3184
                     /gene="Pitpnm2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    2441..3184
                     /gene="Pitpnm2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    3620..4015
                     /gene="Pitpnm2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; Region: LNS2;
                     smart00775"
                     /db_xref="CDD:197870"
     misc_feature    3620..4015
                     /gene="Pitpnm2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; Region: LNS2;
                     smart00775"
                     /db_xref="CDD:197870"
     exon            419..633
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..755
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..983
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1283
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1379
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1484
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1555
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1803
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1993
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2113
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2352
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2531
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2702
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2867
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3029
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3178
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3295
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3412
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3561
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3711
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3895
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4024
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..6900
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtccctg cgtggtggtt cctcacacag ccaggggact gtgtgctggc acttgcaggc
       61 atgagctgcc tgtagctgcg ggctggctgg ggacggctct ctgagacctg catgtgggaa
      121 gccagcagag tctgcaggat ggggccgctg agcggggctc cagccagcac ctgctgcgtg
      181 aggctcctgc tctggtactt tggtgcctca ctccccttac ctcacgttgg cttcctgaaa
      241 gggtcttcag tgaattctgt catggttatt taaggaatct tgcctagaaa gtccccacaa
      301 gcacgaagtc ccctgccgcc cagaaggcgt ggactccaag atgatcataa aggaataccg
      361 gattcccctg ccaatgactg tggaggaata ccgcatcgcc cagctgtaca tgatacagaa
      421 gaagagccgg aacgagacct atggacaagg cagcggagtg gagatcctgg agaaccgacc
      481 ctacacagat ggtcctgggg gctccgggca gtacacccac aaggtgtatc atgtgggcat
      541 gcacattcct ggctggtttc gctccatctt gcccaaagca gccttgcggg tggtggagga
      601 gtcctggaac gcctacccct acacccgaac aaggttcacc tgcccctttg tggagaagtt
      661 ctccattgac attgaaacct tttataagac agacactggg gaaaacaata atgtgttcaa
      721 cctgtctcct gtggaaaaga accagctgat aacagacatc atcgacatcg tcaaggatcc
      781 tgtgaccccc agtgagtaca agacagaaga agaccccaag ctcttccagt cgatcaagac
      841 tcgccgggga cctctctctg aaaactggat tcaggagtac aagaagcggc tcctccccat
      901 catgtgcgcc tacaagctct gtaaggtgga gttccggtac tggggcatgc agtccaagat
      961 cgagaggttt atccatgaca caggcttgcg gcgggtgatg gtgagggccc accggcaggc
     1021 ctggtgctgg caggacgaat ggtatgggct gaccatggag aaaatccgag agctggagaa
     1081 ggaggtacag ctcatgctgt cccgcaaaat ggcccagttt tcggaggaag gaccatcaga
     1141 actaagcaag gagagtacaa tcaaggacca ggcaactgga gcaactcctg aacccagcag
     1201 cagcaatggg gagtctctgg ggcggggtct gaagaagcag tggtccacct cctccaagtc
     1261 ctcaaggtcc tccaagcgcg gagccagccc ctcccggcat agcatctcag agtggagaat
     1321 gcagagtatc gccagggact ctgacgaaag ctcagaagaa gagttcttcg atgcacaaga
     1381 aaacctgcag cacaaggagg aaatgtacac caaggacatc accaagtgga gctccaatga
     1441 cctcatggac aaaatggaga atccagagcc tgaggaatca caggactctc tctaccacca
     1501 gagtggctct gagttcaggg tggcctccag tgtggagcag ctgaacacca tcgaggatga
     1561 ggtgagccag ccactagcca caccaccctc caagattcac gtgctgctgc tggtgctgca
     1621 tggaggcact atcctggaca cgggagcggg tgaccccagc tccaagcagg gtgacaccaa
     1681 cactatcacc aatgtgttcg acaccgtcat gcgtgtgcac taccccagtg ccctaggcca
     1741 cctagccatc cgcctggtgc cctgcccacc catctgtgcc gatgccttcg ccctcgtctc
     1801 caacctcagt ccctatggcc atgatgaggg ctgtctgtct agcagccagg accacatccc
     1861 cctggctgct ctgcccctgc tggccacttc ctcaccccag taccaggagg cagttgctac
     1921 agtgattcag cgggccaacc tggcctatgg agactttatc aagtcccagg aaggcgtgac
     1981 cttcaacgga caggtctgcc tgattggaga ctgtgtcggg ggcattctgg cgtttgatgc
     2041 cttgtgctac agtggccagc cagtgtctga gagccagagc agtagccgcc ggggcagtgt
     2101 ggtcagcatg caggacgctg acctgctgtc cccgggcatc ctggtgaatg cagcacactg
     2161 ctccggtggt agtggcggtg gcagtggtgg aggctccagc ctggagagca gccggcatct
     2221 gagccgtagc aacattgaca tcccccgaag caacggcacg gaggactcca gaaagcagat
     2281 gcctcgcaaa aggagcgact cctccaccta tgagctggac accatccagc agcaccaggc
     2341 cttcctgtcc agcctccatg ccagcgtact gaggaatgaa cccagctccc gccgctcaag
     2401 cagttccacg atgctggacg gtgccggggc cctgggcaag tttgacttcg agatcgccga
     2461 cctcttcctc ttcgggtgcc cactggggct agtcctagcc ttgaggaaaa cagtcatccc
     2521 ctccctggat gttttccagc tgcggccagc gtgtcagcaa gtgtacaacc tcttccaccc
     2581 tgcggaccct tcagcctccc gcctggaacc gctgctggag cggcgtttcc acaccctgcc
     2641 gcccttcaac atccctcgat accagcgcta cccgctgggg gatggctgtt ccacactgct
     2701 ggcggatgcg ctccagaccc acaacacagt cttccaagag catgcagccc cctcgtcacc
     2761 cggcacagcc cctgctagcc gtggcttccg cagagccagt gagatcagca tcgccagtca
     2821 ggtgtcaggc atggcggaga gctacacagc atccggcatt gcccagaagg gtccctcgtc
     2881 gctcaaccac acccccagca tcaggcgcct atccttgctc gccctgcccc ccccatcccc
     2941 taccacccag ggtccccgtg ccagggcaag gcaggtgagc cccaacctgg agaggggccc
     3001 ctgcctccct gacttggaca tcggagaagt tgctgccaag tggtggggcc agaagcggat
     3061 tgactacgcc ctgtactgcc ccgacgccct catggccttc cccacagtgg ccctgcccca
     3121 cctcttccat gccagctact gggagtcaac cgatgtggtc tcctttctgc tgagacaggt
     3181 catgcggcac gacagcgcga gcatcctaga gctggacggc aaggaggtgt ccgtgttcac
     3241 gccttcgcag cccagggaga agtggcagcg caagagaacc cacgtgaagc tccggaacgt
     3301 ggcagccaat caccggatca atgatgcagt tgccaatgag gacggcccac aggttgtgac
     3361 aggccggttc atgtacgggc ccttagacat ggtcaccctg actggggaaa aggtggatgt
     3421 gcacatcatg acgcagccgc cctcaggtga gtggctgtac ctagacactc tagtgaccaa
     3481 cagcagtggg cgtgtctcct acacgattcc agaaacacac cgcctggggg tgggcgtgta
     3541 ccctatcaag atggtggtca ggggagacca cacatttgcc gacagctaca tcactgtgct
     3601 ccccaagggc acagagtttg tggtcttcag tatcgatggc tcctttgcgg ctagcgtgtc
     3661 catcatgggc agcgacccca aggtgcgcgc cggggctgtg gacgtggtgc gacactggca
     3721 ggacctgggc tacctcatca tctatgtgac cggccggccg gacatgcaga agcagcgggt
     3781 ggtggcatgg ctggctcagc acaatttccc tcacggtgtg gtgtccttct gtgatggcct
     3841 ggtgcacgac ccgctgcgcc acaaggctaa ctttctgaag ctgctcatct ctgagctgca
     3901 cctgcgcgcg catgcggcct acggctccac caaggatgtg gccgtctaca actccatcag
     3961 cctttctccc atgcacatct acattgtggg ccgccccacc aagaagttgc agcagcagtg
     4021 tcagttcatc acagacggct acgcggccca cctggcccag ctcaagtaca atcaccgggc
     4081 gcggccagcg cggaacacag caacgcgcat ggctttgcgc aagggcagct tcggtctgcc
     4141 tggccaaggt gacttccttc gctcccggaa tcacctgctc cgcaccatct cggctcagcc
     4201 cagtgggccc agccatcggc acgatcggac acagacccag atggacttgg agcagcgggg
     4261 ccagcgcagc atgagcatgg cggccagttg ctggggccgt gccatggcag gccggcttga
     4321 acccggggca gccacaggac ccaagtagga ccccctcagg aggcgctgtg gtctccatgg
     4381 tgctaggcca gggcaccggc cctcctgggc acacgtaggt ggctggggac acagacagga
     4441 cctgagagct tgtcccgggg cctcttggaa gacagccatg ccaacccagt cctcccagcc
     4501 ttgcccaatg ccctaggctc tgaggagccc agctagtcat ggaaactggc aggaggtcca
     4561 gcccatgacg gaagaggaac caggatcggc cacttagccc agcctgggag gcattcctgg
     4621 acgtcttgct ctgtgttgat ctctcagcct cctggtggca ggcatgggtc ttggccttgc
     4681 ctgtcacctc cctgtccact ggcgcccctt cccatttggc agcagctcca atggggtcta
     4741 acctgcttct tgttgactcc agttttcaac tgtccaacct cactggtttt gcactggttt
     4801 ttgagagtgg agacccgtta ccacctcctg gctccagaca tgttgacatg catgaaaatc
     4861 cagtctctgc tgatccaggg cctgtcacca cacagaatat tccagtgtgg aaagttttca
     4921 cgcaagcagg agagaaaggc cataccttag tttctgctgc ctgcctgggc tgccgacacc
     4981 acagcagccc gatggcagtc ccagactgct acccacctgt ccacctgccc cacccagagc
     5041 tcagtgcagt cccagagccg atgtcactcc gggccctgag cacagcacag gtgtgaggcc
     5101 aggaaagtgc acggctggct cttcgtagcc caccttgggc agctggacct gaagaggcct
     5161 ggcctccacc tctactcctc gccggccatg ggcggggacc ccgtgccatg gctgctgccc
     5221 accgtgtttc tacgcctttc tacttctcca tccggtttct ataaggtttt ttttaacagg
     5281 caatcctggg ctgcttcctt ttcttaactc agtgtcagcg cagcctgcta cattaggaac
     5341 acccagcact gtgacagggt cccactcagt ctggcctgtg ggccctgcac ctggcccact
     5401 tggcaaggtg tgggtttctt gcctcacctg acccacaatt ccaccgactt cctactctgg
     5461 tgtgggtggg gctcttaggt tttcttaatg ccattctgtt ttaatgtcga ctccaagaag
     5521 ccacagctca catgtcagcc tgagggcgta cagccatttt atttctctcc aaacaaggat
     5581 gggcatctta cacgctgggt ctgggccctg ccttccgcac agcactgacc acgaccctac
     5641 tgcaccttct gtgttggctg agctcacgga gctcaggcct cctgtccagt gacggggctc
     5701 tgcttgagta gctgccaagc tggactcaga ctcagggccc cgtggctggg tcaagaggcg
     5761 tataggagac actgactttg ctgtgtagtt acgtacagca caggggcgtg ggattcccgc
     5821 cacggccggt ctacacggga agaaagctat ttattttgtg cagaggaaaa aaaaatgtct
     5881 ggaggggtga ggccttcagg gtctcctcat ccatgtagct ttgtgctgtt cccagcgttc
     5941 tgtataaagc agtgattatc ttatggacca agattccatg gagctgtcac ggtaaaagtg
     6001 caatatttgc cccaccactc ccacaggaag ctgctggccc gacaatcact gccccattgc
     6061 gggcaccagg ggccagggcc tcctccctca ggccccccgt cttgcctcag ctgaggtgac
     6121 tagccatcgg gagaagcacc tagaagcctc aggccacttg cagtcaaggc aagggaggtc
     6181 ctggggtcag tgggcttggt ccctcccctg ggcagccccc tgtggctctg aatgcccatg
     6241 cttgcccagc cgccagccat gccaaggaca acagcaatag tcccctgggc tctcccaggg
     6301 ccctcagcca tagatggtga gacgggcagc cttccccaaa acctcactca agtctgcttt
     6361 ttgcctccct cgagattccc tttggctcat tctcttgagg aagccccact tttacagaaa
     6421 gtaagagagg aaggtcaaag tcctttaaaa ataccaaaaa aatgtttaca gtgtcaggtg
     6481 ctgagctgca gggctcaggc ctggccattc gtaaccaaag ggtgaggcag accttgctga
     6541 ctgccaccca ccccaggcct gttagaatag aagccttagt cagtccctcc ccgtccccag
     6601 tccccaggac tgagccttga tgccacccaa caccaaccac ctgccttctc ttagatttct
     6661 gaagaaggat tcagcaaagc ccatcccctt cctggctctg tgtgagctag ccaccattct
     6721 accctgtttt accttcacat ctcagacacc tcccatcttt gtccttgtac tgtctgttcc
     6781 tctggaccat tgtgtgaact gtcctgaccc cccatgctgt ccctgcatcg tctggcctga
     6841 gtgtgctctc tgtatactgt gtcacagtct gttacaccaa ttaaagaagc aggaggcttc
//
LOCUS       NM_001437325            8260 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            2 (Jakmip2), transcript variant 2, mRNA.
ACCESSION   NM_001437325 XM_063277367
VERSION     NM_001437325.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8260)
  AUTHORS   Cruz-Garcia,D., Vazquez-Martinez,R., Peinado,J.R., Anouar,Y.,
            Tonon,M.C., Vaudry,H., Castano,J.P. and Malagon,M.M.
  TITLE     Identification and characterization of two novel (neuro)endocrine
            long coiled-coil proteins
  JOURNAL   FEBS Lett 581 (17), 3149-3156 (2007)
   PUBMED   17572408
  REMARK    GeneRIF: NECC 1 & 2 proteins primarily expressed in
            (neuro)endocrine tissues in vertebrates thus supporting a role for
            these proteins in the regulated secretory pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2139602.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000018.1  35998552-35998896   c
            346-843             JAXUCZ010000018.1  35893106-35893603   c
            844-1053            JAXUCZ010000018.1  35889442-35889651   c
            1054-1152           JAXUCZ010000018.1  35887501-35887599   c
            1153-1299           JAXUCZ010000018.1  35883648-35883794   c
            1300-1440           JAXUCZ010000018.1  35882878-35883018   c
            1441-1497           JAXUCZ010000018.1  35880934-35880990   c
            1498-1617           JAXUCZ010000018.1  35879957-35880076   c
            1618-1746           JAXUCZ010000018.1  35878661-35878789   c
            1747-1830           JAXUCZ010000018.1  35876787-35876870   c
            1831-1929           JAXUCZ010000018.1  35872906-35873004   c
            1930-2028           JAXUCZ010000018.1  35871950-35872048   c
            2029-2082           JAXUCZ010000018.1  35871138-35871191   c
            2083-2148           JAXUCZ010000018.1  35870288-35870353   c
            2149-2217           JAXUCZ010000018.1  35866017-35866085   c
            2218-2295           JAXUCZ010000018.1  35856809-35856886   c
            2296-2499           JAXUCZ010000018.1  35854261-35854464   c
            2500-2565           JAXUCZ010000018.1  35848371-35848436   c
            2566-8260           JAXUCZ010000018.1  35833986-35839680   c
FEATURES             Location/Qualifiers
     source          1..8260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..8260
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="janus kinase and microtubule interacting protein 2"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
     exon            1..345
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    127..129
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="upstream in-frame stop codon"
     CDS             343..2649
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     2 isoform 2"
                     /protein_id="NP_001424254.1"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
                     /translation="MVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQ
                     AVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQ
                     FDAERLKLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWES
                     ERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSS
                     PKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRE
                     TEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKS
                     LNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPF
                     IGYDEDSMDSETSSMTSFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAY
                     ALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQIEKQEAENHRLQ
                     QELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNI
                     PDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESD
                     MEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSDKQQE
                     ELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEE
                     KKNQELGSYPKKANAFKPSKMAKLFTPM"
     misc_feature    <346..2580
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <346..2580
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    1441..1959
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1441..1959
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     exon            346..843
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1053
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1152
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1299
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1440
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1497
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1617
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1746
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1830
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1929
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2028
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2082
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2148
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2217
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2295
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2499
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2565
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..8260
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctaccg cagcaggggt ggggctgtgg gggtggggag ggaaggagga gcctgaggag
       61 gtgtctgctg caagttcctg gctgattctg agctcacacc atcctccaag agggaggagg
      121 ctcaagtgat gctgctgctg ttgccgcctc tactgctggt actctagtgg agctgggaag
      181 ggtggttcct atcgcaccat cgccaaccgg agagggaggg ggaaaaaaat cctggtagcc
      241 gctgctgatg ttgggttcag aggctgcatc cgacccggtc acaagaaaaa tggattcagt
      301 gtgcggctct ccctcttttc agcatcttct cctgctctca acatggtatc aaagcttgaa
      361 agagagaaga ctcaagaagc aaagaggatt cgtgagctgg agcagcgcaa acacacagtc
      421 ctggtgacag agcttaaagc caagctccat gaggagaaga tgaaggagct gcaggctgtg
      481 agggagaatc tcatcaagca acatgagcag gaaatgtcaa ggacagtgaa ggtgcgggat
      541 ggagagattc agagactcaa gtccgctctg tgtgctctcc gcgatggcag cagtgacaaa
      601 gtaaggacag cactcaccat tgaggcccgg gaggaggcca ggaaacagtt cgatgcagag
      661 cgcctgaagc tcctgcagga aattacagac ttaaaaaccg ccaagaagca ggtggatgag
      721 gctctgagca atatgatcca agcggataaa atcaaggctg gggaccttag gagtgagcat
      781 cagtcccacc aggaagccat ctcgaagatc aagtgggaat cggaacggga tatacgaagg
      841 ctgatggatg aaatcaaagc caaggacagg atcatcttct ccctggaaaa agaactggag
      901 actcagacag gctatgtaca gaaactccag ctacagaaag aggctttgga tgagcagctc
      961 ttccttgtca aggaggcaga gtgtaacatg agcagtccga agagagagat tccaggaagg
     1021 gcaggggatg gctctgaaca ctgcagcagc ccggatttgc gaagaaatca aaagagaata
     1081 gccgaattga atgccactat acgaaagtta gaagacagga acaccttgct cggagatgaa
     1141 cgaaacgagt tgttaaaacg tgtgcgggaa actgaaaaac aatgcaaacc tctcctggaa
     1201 aggaacaagt gcctagccaa gagaaacgat gaactgatgg tatctctaca acgcatggaa
     1261 gagaaattaa aagccataac caaggaaaat tcagagatga gagagaaaat aacgtctcac
     1321 ccaccattga agaaactgaa gtctctgaat gaccttgatc aagctaatga agaacaagag
     1381 acggagtttc taaaactgca ggtcattgag cagcagaaca tcattgatga gctcaccagg
     1441 gatcgagaaa aactcatccg taggagaaag cacaggagaa gctcgaaacc aatcaagagg
     1501 cctgttttag atccgttcat tggctatgat gaggattcga tggattcaga aacatcatcc
     1561 atgacctcct ttagaacaga ccggacacct gctaccccgg atgatgactt ggatgaaagt
     1621 ctagctgctg aagaatctga gctacgattt cgacaattaa caaaagaata ccaagccctc
     1681 caaagagcat atgccctctt gcaggaacag actggaggca tcatagatgc tgaaagagaa
     1741 gccaaggcac aagagcagct ccaggcagag gtgctgaggt acagggccaa aatcgaagat
     1801 ttggaagcaa cgctggctca gaaagggcag atagagaagc aggaagcaga gaatcaccgg
     1861 ctacagcaag aacttcagga tgccagagac cagaatgagc tgctggagtt tcgcaaccta
     1921 gaactagaag agagagagag gcgatcccct ccattcaatc tacaaattca ccccttctca
     1981 gatggtgtga gtgcactgca gatctactgc atgaaagaag gtgtcaagga tgtcaacatc
     2041 cctgatctca taaagcagct tgatatcctt ggtgacaacg ggaatctaag gaatgaagaa
     2101 caggtggcca taattcaggc cagcactgtg ctgtccctgg cagagaagtg gatccaacaa
     2161 attgaaggag cagaggctgc cctgcaccag aaaatgatgg aactggaaag tgatatggaa
     2221 caattctgta aaatcaaagg ctacctggag gaagaactag actacagaaa acaggctctt
     2281 gaccaggcat atatgagaat ccaggaacta gaagctactt tgtacaatgc tctgcagcaa
     2341 gaaactgtga tcaagttcgg tgaactgtta agtgacaagc agcaagagga gttgaggacg
     2401 gctgtagaaa agttacggcg gcaaatgctg aggaagagcc gggaatatga ctgtcagatc
     2461 ctccaggaga ggatggagct cctacagcaa gctcaccaga ggatccgtga cctagaagat
     2521 aaaacagaca tccaaaaacg gcagataaag gacctagaag aaaagaaaaa tcaagaactt
     2581 ggatcatacc ccaagaaggc aaatgctttt aaaccttcaa agatggcaaa attgtttaca
     2641 ccgatgtaag ggaaatcaaa agctaagaat taccctgtag ccaagactat gagctttaaa
     2701 gccattattc aaggtttctt acttgacagt ttataatgac cctgttgaaa aatctacatt
     2761 atatgctgca attaatgaaa cgtgtgtatg tcaaaccgga agagaactat aaacatatat
     2821 tgtgggaagg aaaatttcag cagtggaacc agtttcagca gatcaaaaga agatgtgtct
     2881 tgggcatgga accaaagtta caatgaacca ttcaactcct gctgtgcagg gggggtcatt
     2941 ttaatgtaac accacacccc atggaaacac tattcctgaa aataaacatc attttaaaaa
     3001 aaaacaaaac aaacaaaagt gaaaaaaaaa ccaacttaag ggtgggcggg taatgaagca
     3061 cgaggaataa tacctatgag gaactattta caataaaatg tttcatttga aaagtctggt
     3121 ttcttactac agggatttgc ttttctgtct ttatgattgt tttaaactca ggaacagaga
     3181 catctatgat gaggagggaa gaaaaatact ctccattttg tttctccaaa aggtggagtt
     3241 ggggatgaga agtggattct agttactcta caagcgcaga gccaagggac tctgaggagt
     3301 ttaacatgga gtggaattgg aaatctatgc ttcctcatat cacacacctg catctctcca
     3361 ccatggatgg actggtctcc tccgtactga acaaggtgaa aattatactc agaagtcaca
     3421 aaccgcctaa cttagctctg tcgaaaacat caagatctat agggaactag ggccaggaag
     3481 caactctgca gcttccagat tcaagttaaa attgcctgca gatgaatatg ctgtctgact
     3541 tgtgtgaaga ccccacagaa atgatgagaa gctgacaact gaacgtgggg ttcccagaga
     3601 gctgcgcatg ttgagtatcc cagagcaatc tgaactcttg tcacttagaa caatagcatt
     3661 attttctgag atcgctgtcc gcaacaagac gtctctactt ttttatagac aacactgaca
     3721 agctggttct ctatcacagg cagatagaca actaacactt ttcctaagtc acatattaca
     3781 gagtattggt ttcagcaatg gcagtaaata tatcctcctg aaaagctgat tttacacgtc
     3841 cttgactgta gataacaagg caacctcaat ttctcaaata ctcaatgttt tctttccagg
     3901 tttagaaatc ccatgcatcg agaatgtgtg tagggagcca ggaactcttt ctatgaaatg
     3961 ctacacaaac aggtccatat gtgaattgag tatattctcc ttcagtttta acactggcaa
     4021 tttcaaagcc agagcaactg aagaatcttc aagacaaaac agattcctgg ggtcccacat
     4081 ttttgtcctt gtatttaatg ctgacccaac tgtttggccc agtcactgaa cctctctgtg
     4141 cctcagtttc ctcatctaaa aaaatgggga ttaaatgttt tgattttttt cctaaggttt
     4201 tgtttgcaat tctggaacaa gaggtgctta aggtagcaca aagtgctttg taaccgttat
     4261 aaatgctgta ttatttgact tccctgtata atgaaatagt tcctgagttt gattcaaaca
     4321 gcagagcatc actgaagcgt ccccatcaag ctgcctagga cattattagc aataaattgt
     4381 gagattcaaa aaccacaata ttgaatctat aggaaataga ttgactcgtt ctattgagaa
     4441 agacagaaag tgtgtcattt caatgctaag cacctcccat gctctcctga ttgcataaca
     4501 tgccatcaat cgaaaccccc aacatcatca caggagagcc aaccatgcaa ctacggattg
     4561 ccaagaacag aaagcaacaa agaaagccga tattattttt caaagaatgt cagatgatgt
     4621 gtcctaatgc aaaaacttta aaagtcagaa ctgtactaat ggattctttg tacaactaag
     4681 gtaagtccca gatccccgca attagcaggt tcattgtgca ggtgatgtga aacagggtac
     4741 ttctcctaca ccggccaccc agctaactca gtcctgtatg ggagtacaca aacggcttgt
     4801 ttactgcttc aattatactt cacctactat tataggaccc acttgagaaa atgcatactt
     4861 aatctgctcc gtacatgcct tcctcctctc cttttgcttt tcctatcgaa aacctggtgg
     4921 gtaaattttc atatcagaga actatgtcta aattattatg aatgccaata atatgctata
     4981 tgttaccctg ttgttagtca aattgcataa aacccatgct gaactttctg agagcgaaag
     5041 ccacttgagt aatcatctct gaaactttga ttggtgggag ggggaggctt tctttctgtt
     5101 taatatccag aatatcactc tagatcgtaa gctaaatgat gacatcttta tcaggtgttc
     5161 gtcatagtcc tcaaaatgag tgctctaata tttagactag gaaagtttaa atattttgat
     5221 agagtccata tctacgatga cagcatcaag aaaaactgga ggtgtgcgtt ttgcttattc
     5281 acagatgcct gagaatggtt tctatcttag tgaatgcttc cttgcatatg atgctcagaa
     5341 tagccaaaag aatgtactat tagtaacaaa gagttgtgct gtgacatcgt ttctcatttt
     5401 caaaagaaaa aaaaggtaat tcctactcca ggttttaaat tttggtatct gtacttagct
     5461 agagatttgg ggggatgggc acaataagag tacacctaac tactttttct tagccatgta
     5521 ctcatctctc tgaatcccac tgaagtagtt tgagaggtga aagcttaaca ctgtcaggac
     5581 ttctcagatt tccataaaag aaatgcacag actctatatg atatccattc tacaaaacaa
     5641 ggtcagcaac ttcagcatct tgtcttaaat gccatctaac ttatttcagt tgaaaaatta
     5701 aattagcact gtcagatcct gtttgactta tgtcatattc gctaaattgc tgctaaaagt
     5761 gaggttttaa caataaaagc atactttgtt ttgctttttt ttcccctaca attcagaata
     5821 agtttatatc aaagtataaa attcttccca acgttcgaga tgtgcatcat cactggggtc
     5881 agaaagggcc ttcaattgcc atagaagaaa taaaatttgc caaatcattt gtgctgtggt
     5941 attttatttc aaaccgttgg ggtgtttttt tctacttgaa ataaatctca ccaatttttc
     6001 ttctgctgat ttattgctaa ctttttctaa aaacacacaa taaaatctgt atgtttataa
     6061 cttaaatgga attgataagc accttctttt aaaacaatgc ttatcatttt aacttgcctg
     6121 ggttttcatt gaaagctgta aaaagagcat ctgttggtta tgttgatatt taaataacta
     6181 gaccatctct gcgatgtcac atcagaatag atgaccagtg tactcagtat taaagcatat
     6241 agatgtgttc tttttatttg tcaaagaacg gaatggaata ctccctctcc ctccccctct
     6301 ccctccccct ctccctcccc ctctccctcc ccctctccct ccccctctcc ctccccctct
     6361 ccctccccct ctccctcccc ctctccctcc ccctccccct ctccctcccc ctcccccccc
     6421 tctctctctc tcacacacac acacacacat acaatatgtg taccaagaca agatttgtaa
     6481 gactcagcta tgttgattgg cagttgcatt gcttttgtga cgcttccact gccctctctc
     6541 cctcccccct ccactcttcc ctcctgcttt ttgttttctt ttttatactg gtgctatagg
     6601 ttgaatccag gtgcctgggc attctagaca gcacacagct gtatctcccc agaccccagc
     6661 cctggtaatt taatatattt tagggattaa atttgatcta ctatatggaa agtacataaa
     6721 tgtaactttt gaagtataac ttatgcaagt agctcttaga tggctgtgcc atggtgttca
     6781 ggatggatgc aaagccccct ttctgcttag atggggaaaa gacataagat aaagatttcc
     6841 ttattcccaa ctgctttata cttttcatat agaatatgcc tagagactag attccatact
     6901 tatatacaag aggactttca atgctggaag aatggggttg ttcctcggga tgtcacttca
     6961 gaactgagca aggcaggttt tcttcccatc cctgatttta tcagttgagt tcctcctcaa
     7021 taaatcttta ttgctgagag agcctgagtt gagttcttaa tttgactttt aaaagataca
     7081 tgtaaagggg cagtacagga aagtggactg aaattcacca cattcactct agtgtgacaa
     7141 acctgtaatt gattcactga agctttctgg ttttattttg ctatttgatt ttgtactgaa
     7201 atctttgttg tataaagtcc tacagggcgg caatggtgca gacaaacaat gttgagtccc
     7261 ctttgcccac atgaagactc tacaaactta ctaaagaatg aatgatccaa tctctcaatc
     7321 agaaacagat ctggaacctg ctataaactg cagtcactta agtttgacag acacctcaca
     7381 aaacgtgcct atttcccctc ttaactaaac catctctcct gaataaggca aatcaaaatc
     7441 taaacactta ataaatacaa gatgtacata gtcatgcata tgtatcctgt acagagtatg
     7501 gtggtgcagg cattaacaga tatgtacttc agacctcgac agaagactta gagatgatgc
     7561 ttttctgatg tcactaggca actcgatttt gtttggcgta tagtgtctat acccacccct
     7621 ccttggctat atctctacct tccaccatta ctgctatttc ctgttgcctg tgaattttcc
     7681 acgaccctgt cctctaagca gaacgttttg ttccctagca tctcaataaa acgcccagca
     7741 caatttacag tattaatatc aatcaaaggt cctatgcttt tctcaactaa aattgcattt
     7801 ccagaagctt ctgtgcatga tctaacctat agtatttaat tctgtgagga tttgagttta
     7861 cagggaacat atttgaatcc acaattcctt gtgtatctat tgagttagtg tagccagggg
     7921 gctggtttcc aaagcattcc tacgattgcc tgcattagtt caggtccttc ctatcacagc
     7981 atgactagta ggccacttca gtgcttactg atgagaggca gaacttgatt gaatgcagca
     8041 gagggattgt ctgaggttca cgggacaggt acatgtgctg tatgtatcac catagagatc
     8101 ggaatccatt tattgtatgt aaagttttat gaacggttat tttataattt atgtatttaa
     8161 tatagcaatc aatgaactct ggtgttttag tttctatgaa aaataaaaca aactgcattt
     8221 tttaaaaaaa ataaaagctt ttaccttgtg ttattcataa
//
LOCUS       NM_001437221            2905 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            6, mRNA.
ACCESSION   NM_001437221 XM_006249117
VERSION     NM_001437221.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2905)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2905)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2905)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249117.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.34967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000012.1  24761280-24761362   c
            84-130              JAXUCZ010000012.1  24761121-24761167   c
            131-184             JAXUCZ010000012.1  24760247-24760300   c
            185-431             JAXUCZ010000012.1  24759745-24759991   c
            432-609             JAXUCZ010000012.1  24759477-24759654   c
            610-750             JAXUCZ010000012.1  24756632-24756772   c
            751-862             JAXUCZ010000012.1  24756440-24756551   c
            863-985             JAXUCZ010000012.1  24756223-24756345   c
            986-1102            JAXUCZ010000012.1  24754191-24754307   c
            1103-1242           JAXUCZ010000012.1  24753946-24754085   c
            1243-1406           JAXUCZ010000012.1  24752946-24753109   c
            1407-1526           JAXUCZ010000012.1  24751630-24751749   c
            1527-1609           JAXUCZ010000012.1  24749484-24749566   c
            1610-1673           JAXUCZ010000012.1  24749332-24749395   c
            1674-1741           JAXUCZ010000012.1  24749165-24749232   c
            1742-1818           JAXUCZ010000012.1  24749003-24749079   c
            1819-1903           JAXUCZ010000012.1  24748839-24748923   c
            1904-2131           JAXUCZ010000012.1  24748522-24748749   c
            2132-2272           JAXUCZ010000012.1  24748072-24748212   c
            2273-2905           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2905
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..83
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    59..61
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="upstream in-frame stop codon"
     exon            84..130
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..184
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2548
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424150.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    218..229
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    224..283
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    395..457
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    566..>727
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    566..>727
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    767..1339
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    767..1339
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    854..856
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(1043..1045,1085..1096,1100..1102,1112..1123,
                     1130..1132,1136..1144)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1043..1045,1085..1096,1100..1102,1112..1123,
                     1130..1132,1136..1144)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1115..1117,1133..1135)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1115..1117,1133..1135)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1130..1132,1139..1141)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1130..1132,1139..1141)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1142..1144,1148..1150,1160..1165)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1142..1144,1148..1150,1160..1165)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1151..1153
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1361..2062
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1361..2062
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1382..1384,1388..1390,1397..1399,1403..1408,
                     1412..1414,1544..1546,1550..1552,1601..1603,1610..1636)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1382..1384,1388..1390,1397..1399,1403..1408,
                     1412..1414,1544..1546,1550..1552,1601..1603,1610..1636)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1754..1756
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2141..2515
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2141..2515
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            185..431
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..609
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..750
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..862
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..985
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1102
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1242
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1406
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1526
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1609
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1673
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1741
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1818
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1903
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2131
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2272
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2905
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acaggcacga ggcagggact gggctgcggg tcctgggatc ttcagcgcgg cttggatttc
      121 aaactggagg ggttcaggag ggggcacaag catggaacaa cgttggggtc tacttcggaa
      181 agtgcaacag tggtccccaa gaccctctca gaccatctac agacgtgtgg aaggccctca
      241 actggagaac ctagaggagg aagataggga ggaaggggag gagcttcctg cccagttctg
      301 ccccatggaa ctcaaaggcc ctgagcgctt aggctcctgt cctgggaggt ccattcccat
      361 accctgggct gcagcaggtc gaaaggctgc tccctatctg gtcctgacca ccctgctaat
      421 cttcactggg gccttcctcc tgggctacgt ggcctttcga gggtcctgcc aggcatgtgg
      481 ggactctgtg ttggtggttg gtgaagatgt caactctgag gactccagcc ggggcacgtt
      541 gtactggagt gacctccagg acatgtttct ccggttcctt ggggagggac gcatggagga
      601 caccatcagg ctgaccagcc tccgggaacg cgtggccggc tcagccagaa tggccaccct
      661 ggtccaagac atcctcgata agctctcgcg ccagaagctg gaccacgtgt ggactgacac
      721 gcactatgtg ggacttcagt tcccggaccc ggctcaccct aacaccctgc actgggtggg
      781 tgcagacggg agcgtccaag agcagctacc gctggaggat ccggaagtct actgtcccta
      841 cagcgccacg ggcaacgcca cgggcaagct tgtgtacgcc cactacgggc ggcgggagga
      901 cctgcaggac ctgaaagcca aggacgtgga gctggccggc agcctcctgc tagtgcgtgc
      961 tgggattaca agcttcgccc agaaggtagc cattgcccag gactttgggg cccacggagt
     1021 gctgatatac cctgacccag cggacttctc ccaagacccc cacaagccag gcctgtctag
     1081 tgacagggct gtgtatggac atgtgcacct gggaactggg gacccttaca cgcctggctt
     1141 cccgtccttc aatcaaaccc agttccctcc agtagaatca tcggggcttc ccaacatccc
     1201 tgcccagccc atcagtgccg acgttgctga tcgcttgctc aggaaactca caggtcccgt
     1261 ggctcctcag gaatggaagg gtcgcctctc agactctccg tatcgcctgg gacctgggcc
     1321 aggcttacgc cttgtggtca acaaccacag aacctctact cccatcagta acatctttgc
     1381 gtgcatcgag ggcttcgcag agccagatca ctatgtcgtt atcggggccc agagggatgc
     1441 ctggggccca ggagcagcca agtctgcagt ggggactgcc atcctcctgg agctggttcg
     1501 gaccttttcc tccatggtca gcagtggctt tagacctcga agaagtcttt tgttcatcag
     1561 ctgggacgga ggtgactttg gcagcgtggg agccacggag tggttggagg gctacctcag
     1621 cgtgctacac ctcaaagctg tcgtgtatgt gagcctggac aactccgtgt tgggagacgg
     1681 caaattccat gctaagacca gcccccttct cgtcagcctc attgagaata tcctgaagca
     1741 ggtggattcc cctaaccaca gtggacagac actctacgat caagtggcat tcacccaccc
     1801 aagctgggat gctgaagtga tccagcccct gcccatggac agcagcgcat attccttcac
     1861 agcttttgcg ggcgtcccag ctgtggagtt ctccttcatg gaggacgata gggtgtaccc
     1921 attcctgcac acgaaggagg acacgtatga gaatctgcac aagatgctgc gaggtcgcct
     1981 gcccgccgtg gtcctagcag tggctcagct cgctggtcag ctcctcatcc gactgagcca
     2041 cgatcaccta ctgccgctgg acttcggccg ctacggagac gtggtcctca ggcacatcgg
     2101 caaccttaat gagttctctg gggacctcaa ggcgcgcggg ctgaccctgc agtgggtgta
     2161 ctctgcaagg ggggactata tccgggcggc ggagaagctg cggaaggaga tttacagctc
     2221 ggagcagagc gatgagcgtc tgatgcgcat gtacaacgtg cgcatcatga gggtggagtt
     2281 ctacttcctg tcccagtacg tgtcgccggc cgactcccca ttccgccaca ttttcctagg
     2341 ccaaggcgac cacactttgg gtgccctggt ggaacaccta cggatgctgc gctccgatgg
     2401 ctcaggagct gcctcttctg ggttgagccc aggtctgggc ttccaggaga gtcgcttccg
     2461 gcgacagctg gcgctgctca cgtggacgct acagggggca gccaacgcac tcagtggcga
     2521 cgtttggaac atcgacaata acttttgagg ccagaagtcc tccatgggcc ccacgtgatt
     2581 ctcctttctc cctatttgag tggtgcaggc aacggaggtg cctgagagca acctatcctc
     2641 attaacaacc ttggtcctgc aacgccagtg agacatattt tctcagtgtg actgttatac
     2701 cactgtttat ccagaaagcg gttttcttcc catcactggc ctctctgcct tcaggagcat
     2761 agttccccat atctagaaac catctagaca ctgggatcca gctctcttag cgggtgagat
     2821 ggatagcgtc attttcttat gacacacaag tggtatgtgg gtggcccaag ggggattaga
     2881 tgtcaataaa ccatttacct ggtaa
//
LOCUS       NM_001437411            3066 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437411 XM_063285562
VERSION     NM_001437411.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063285562.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.78666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000001.1  165852282-165852575
            295-437             JAXUCZ010000001.1  165857589-165857731
            438-579             JAXUCZ010000001.1  165859584-165859725
            580-735             JAXUCZ010000001.1  165862675-165862830
            736-914             JAXUCZ010000001.1  165864598-165864776
            915-1000            JAXUCZ010000001.1  165866964-165867049
            1001-1173           JAXUCZ010000001.1  165867251-165867423
            1174-1249           JAXUCZ010000001.1  165869240-165869315
            1250-1380           JAXUCZ010000001.1  165870275-165870405
            1381-3066           JAXUCZ010000001.1  165870906-165872591
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3066
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..294
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..437
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    372..374
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             393..1616
                     /gene="Xndc1"
                     /note="isoform 1 is encoded by transcript variant 2; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 1"
                     /protein_id="NP_001424340.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQ
                     LKVEFQLERAVPISYIDVGNCGCAFLQIDVGRSSWPLDRPFVTLLPATMLMSLTDSKE
                     GKNRSGVRMFKDDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDP
                     VKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQL
                     QPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRG
                     KRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSI
                     EALPRHAATCGESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICELQFSAR
                     EIEEHASVCGEVFPA"
     misc_feature    393..842
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    393..842
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            438..579
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..735
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..914
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1000
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1173
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1249
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1380
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..3066
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgacc cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata
       61 tatattaaaa actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct
      121 gtacttcctc agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg
      181 ttttgggcta cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa
      241 taagatctga gcaccgaaac tgaagctact acgacatgaa gtttatggac gcggctacca
      301 agagcaaaac atagaccgtg tcaccgtggt tacagaagac atcctgggag gaagcatatc
      361 tgcctcgcaa ataaagaagc tggtggcctc cgatggctcc tgtgaagatc agccatgtgg
      421 tgtcattttc ctctcaggat cccaaatatc ctgtggagaa cttgctgaac ccagacagtc
      481 ataagggacc ttggctcagc tgccctcggg acaagactgg gcaactgaaa gtggagtttc
      541 agctggagag agcagtgccc ataagctaca tcgatgtcgg taactgtggc tgtgcttttc
      601 tacagattga cgtgggtcgt tcttcttggc ccctggacag accttttgtc accctgctcc
      661 ctgcaaccat gctcatgtcc ctcactgact caaaggaggg gaagaaccgc tcaggggtcc
      721 ggatgtttaa agatgatgat tttctgattc cagcctcagg agaatcatgg gatcgacttc
      781 gattgacctg ctcccaacct ttcacacgtc atcaatcctt tggcctggcc ttcctccgag
      841 tacgttcctc tctggactct ctgtctgacc ctgtaaagga tccctcatcc cctgggagct
      901 ctgggcttaa tcagaactct tctgataagc tggagtctga tcctagcccc tggctgacta
      961 atccttctat ccggaggacc ttcttcccag atccccagac gagcaccaag gaaatttcag
     1021 cgctcaaggg tatgttgaag cagttgcagc cagggcctct ggggcgggca gcccgcatgg
     1081 tgctttctgc tgcccataag gcacctccag ccagtgtcgt aagcccaaac aatagccatg
     1141 gagaaccaga ttccagtcat cccgagcgtg cagagcccag agcagaagaa ccaaacagga
     1201 agaacaatgc aagcagaggg aagaggagga aagtccagga gcaaaggaga ccgttgtcca
     1261 gctcaagctc tcagccaaat aggagggcaa caggaaggac aaagcaaaga cagcaacgac
     1321 ctcaggccaa aagtgatggc agtggtgtgc aggctactgg acagtgtccc atttgtacag
     1381 gttccttcag tattgaggct cttccccggc atgctgccac ttgtggagag agctccccac
     1441 cccagccagc ttctcctacc tccttgtctt cctcagagtc tgtgctgtgg gtgtcttccc
     1501 cagagagctc gccgccacca tcttcctggg tccaatgccc tatttgtgaa ttacagttct
     1561 cggcaagaga aatagaagaa catgccagcg tgtgtgggga agtttttcca gcctgagcag
     1621 tgacattctg ctaacccttt cttgatgttg gagcctgggg aatggatctc ttgtggctaa
     1681 gaagcattgg tcccctccct tctgtgatta cctcaggact ctgcctgcct gaggacactt
     1741 tggacccagc ttgctcccca ttcccgttgc caaggctgtg tcactatggt acccaattct
     1801 cataaggata ttttcccctt agaacatatt tggtagaatt gatgatctct ccaaggcctt
     1861 agaacactat ctagaatgtg atttccaatg cccatttccc tgaaaggaaa acggaggctc
     1921 acctaggggg aaatactgcc tgaaaattat aaagtcctat gatggtctgg gaagatgagt
     1981 gagtcttgag catgacactg acactgagtc ccatctgacc ttgaccttct atatctttca
     2041 tgggtgtctg ccccaggtgt aatcagatac tgccctgaaa cttcacacta cttaccatag
     2101 gtgtggaatg gacgttcagt gacacaaaaa cccctcacag ggttcttaaa ggaaccagag
     2161 agatttcctt ctaaggaata ggcgtggctg taaaagtttg agcaaatctc gttctaacta
     2221 tttgagatag ttggaccata gtgtctcccc aaggtcccct ggagctgcga tggtccaatt
     2281 ctgctttgaa gaattatgca cgcttccctt ttccccagga gatgtcttca tgtggcacta
     2341 acacccgtcc cccttatccc caaggtacag ggcagggaga gagcagctgg tcctggtgaa
     2401 gggagggctt ggggtggggc cttgagtggg aatgaaagag catgtgagcc gcagtcaagg
     2461 gagaggcaga gcaggagttc aagccttcag cccctgccca cagaagtggg tgcagccatg
     2521 gatccccttt cggtaagaga cccttgcttc cctcccctcc tcatcccagt ccccaggggg
     2581 atgcagggac agcctgctgc tgttggtggg agagcccctg gattcctgat ccagggccta
     2641 gaagaaaaga gcagggagct ggacctggta gaacaggacg caacagtacc aaggagggga
     2701 gatgctctcc aaggtagaag gcagagtgag agtatccggt ggagggaaag caccttaagg
     2761 tcctactaga gtctttcata gagaaagggt ttagggaaag tgcagcttaa agaccctctg
     2821 tgtgggcatg tctgaacttg tccttcagag agatgagcag ctacaagatg ggaactggat
     2881 tcctgtcgga tgtgtatagg ttaggtgcct agtgcggccc caaccaccta ctttaatcac
     2941 ctctcttcag ggaactaact tgggccctgt tatgtctgat ttttataaga atggaagtgg
     3001 gctgagtaaa tactccccat actagctttt cctacatgag tctacataat aaaatggtga
     3061 acaaga
//
LOCUS       NM_001437301             994 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 8, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437301
VERSION     NM_001437301.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 994)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 994)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.68572.1,
                                           SRR26360181.695046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               JAXUCZ010000011.1  44781963-44782325
            364-503             JAXUCZ010000011.1  44823304-44823443
            504-994             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..994
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..363
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    280..282
                     /gene="Mrps6"
                     /note="upstream in-frame stop codon"
     exon            364..503
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..696
                     /gene="Mrps6"
                     /note="isoform 4 is encoded by transcript variant 8; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 4"
                     /protein_id="NP_001424230.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGYFLVDFYAPTN
                     AVESMLEHLARDTDVVRPNIVKHPLTQEVKECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    <406..606
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    <406..606
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(451..453,457..465,505..507,511..513,586..588,
                     598..600)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(451..453,457..465,505..507,511..513,586..588,
                     598..600)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(463..465,475..477,532..534,541..546,565..567,
                     586..588,595..603)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(463..465,475..477,532..534,541..546,565..567,
                     586..588,595..603)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     exon            504..994
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcctcg gaccccggct ctccggagtc cgatggaagg actgcgggag gacacacgcg
       61 cgagaaccca ggccggcccc gctctgcgcc cacgggtcga gaagctgctc gtcgtcccga
      121 tcgcctgccc tcagcgtccg cgatcagtac agccttccac caaagcccgc cagtgccggc
      181 tgtgtacccc acgcacttgt caccgctgtc acgctaaaaa aaaaaatctt ttgacctttc
      241 tttttctgac tccagcgaaa atcctgctcc gggtaccctt agcccagttt tattcatcca
      301 agttgtggcc ttgcttgtgc tttccgaaga cgtgtcttcc cccagctttt gattgatctt
      361 gagccagaga ccgctgctgc tttaaaacgt acaatagaat ccctgatgga ccgaggagcc
      421 atagtgagga acttggaaaa cctgggtgag cgtgcactcc catacaggat ctccagtcac
      481 agccagcagc acagccgagg agggtatttc ttggtggatt tttatgcccc aacaaatgct
      541 gtggaaagca tgctggaaca cttggcacga gacactgatg tggttagacc aaatattgtg
      601 aaacaccctc tgacccagga agtaaaagag tgtgacggca tagtcccagt ccctcttgaa
      661 gaaaaactgt attcaacaaa gagaaggaag aagtgagaag attcaccaga tgtggctatg
      721 ttcaattcta agtgcaccat gggtgctgat aggtttgtct aggatgcttt agcccgtgac
      781 cattttgctg cagatgggga ctgctggccg agacctgctc tgtcacccct gctgatattt
      841 caccctcact gtgtgattgt cagggtgcgg tggggctggt gttcacagtc ccactgcaga
      901 gtttcgaaga acaaaatgtt tgtcattcac actcggttgt cttgtaaacc tgtgtggaac
      961 acagagcaga gtaataaaca tggttttatc aaca
//
LOCUS       NM_001437271            3071 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus checkpoint with forkhead and ring finger domains
            (Chfr), transcript variant 3, mRNA.
ACCESSION   NM_001437271 XM_006249536
VERSION     NM_001437271.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Jung,I., Sohn,D.H., Choi,J., Kim,J.M., Jeon,S., Seol,J.H. and
            Seong,R.H.
  TITLE     SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking
            CHFR mediated ubiquitination and degradation of its major
            components
  JOURNAL   Biochem Biophys Res Commun 418 (3), 512-517 (2012)
   PUBMED   22285184
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Oh,Y.M., Kwon,Y.E., Kim,J.M., Bae,S.J., Lee,B.K., Yoo,S.J.,
            Chung,C.H., Deshaies,R.J. and Seol,J.H.
  TITLE     Chfr is linked to tumour metastasis through the downregulation of
            HDAC1
  JOURNAL   Nat Cell Biol 11 (3), 295-302 (2009)
   PUBMED   19182791
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Yu,X., Minter-Dykhouse,K., Malureanu,L., Zhao,W.M., Zhang,D.,
            Merkle,C.J., Ward,I.M., Saya,H., Fang,G., van Deursen,J. and
            Chen,J.
  TITLE     Chfr is required for tumor suppression and Aurora A regulation
  JOURNAL   Nat Genet 37 (4), 401-406 (2005)
   PUBMED   15793587
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Daniels,M.J., Marson,A. and Venkitaraman,A.R.
  TITLE     PML bodies control the nuclear dynamics and function of the CHFR
            mitotic checkpoint protein
  JOURNAL   Nat Struct Mol Biol 11 (11), 1114-1121 (2004)
   PUBMED   15467728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249536.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85960.1,
                                           SRR26643296.31404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000012.1  52197661-52197734   c
            75-218              JAXUCZ010000012.1  52197409-52197552   c
            219-318             JAXUCZ010000012.1  52193002-52193101   c
            319-428             JAXUCZ010000012.1  52189107-52189216   c
            429-488             JAXUCZ010000012.1  52188275-52188334   c
            489-704             JAXUCZ010000012.1  52187940-52188155   c
            705-869             JAXUCZ010000012.1  52186341-52186505   c
            870-1029            JAXUCZ010000012.1  52182610-52182769   c
            1030-1184           JAXUCZ010000012.1  52181801-52181955   c
            1185-1347           JAXUCZ010000012.1  52180867-52181029   c
            1348-1493           JAXUCZ010000012.1  52178991-52179136   c
            1494-1577           JAXUCZ010000012.1  52175247-52175330   c
            1578-1648           JAXUCZ010000012.1  52174142-52174212   c
            1649-1736           JAXUCZ010000012.1  52172797-52172884   c
            1737-1844           JAXUCZ010000012.1  52168910-52169017   c
            1845-1917           JAXUCZ010000012.1  52167710-52167782   c
            1918-3071           JAXUCZ010000012.1  52164212-52165365   c
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3071
                     /gene="Chfr"
                     /note="checkpoint with forkhead and ring finger domains"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
     exon            1..74
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Chfr"
                     /note="upstream in-frame stop codon"
     exon            75..218
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1960
                     /gene="Chfr"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase CHFR; checkpoint with forkhead
                     and ring finger domains, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHFR isoform 3"
                     /protein_id="NP_001424200.1"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
                     /translation="MEPHGEDEQPPPREPWGRLLRLGAEEDEPQILLWKREWTIGRRR
                     GCDLSFPSNKLVSGDHCKLRVDEKSGEVTLEDTSTNGTVINKLRVVKKQTYPLQSGDI
                     IYLVYRKNEPEHNVAYLYESLNGKQSLTQESLEANKENMFHVTKESSGPGQGDDPQVP
                     LLSPMAQTCLEEPQPSTSTSDLLPTASTSSTEPELTSAGQKHSSSSGPGTISISPKEC
                     SSLVANGELSSLSSVFQDNEASFSLLKTEDTEELEPAKKKMKGDGELDLNLQLSVADQ
                     RGIAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMER
                     SSLCPTCRCPVERICKNHILNNLVEAYLLQHPDKSRSEEDVRSMDARNKITQDMLQPK
                     VRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESEL
                     GATQALGGEAPSTSASLTTGAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDG
                     VLNNNNYESDILKNYLTTRGLTWKNMLTESLLALQRGVFILSDYRITGNTVLCYCCGL
                     RSFRELTYQYRQNIPASELPVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN
                     "
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    <1496..1825
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    <1496..1825
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    1859..1930
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     misc_feature    1859..1930
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     exon            219..318
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            319..428
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            429..488
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            489..704
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            705..869
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1029
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1184
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1493
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1577
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1648
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1736
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1844
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1917
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..3071
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtccccga gatgtctgtt gacagcggtg gcggcgactg tgctgccggt tccgggatcc
       61 gcgcagggag ggggatgtga gtcctatgga gccacacggg gaagacgagc agccgccacc
      121 gcgggagccc tgggggaggc ttcttcgcct aggcgcagag gaggacgaac cccagatcct
      181 tctttggaaa cgcgagtgga ccatcggaag gaggagaggc tgtgacctct cttttcccag
      241 caataaactg gtctctggag atcactgtaa acttagagtg gatgaaaaat ctggtgaggt
      301 gacactggaa gacaccagca ccaatggaac agtaatcaac aaactgcgag ttgttaagaa
      361 gcagacttac cctttacaga gtggggatat catctatttg gtgtacagga agaacgagcc
      421 agagcacaat gtggcatacc tctatgaatc tttaaatggc aaacagagct taactcaaga
      481 atcccttgaa gccaataaag aaaatatgtt ccatgtgacc aaagaatcct caggtccagg
      541 gcagggtgat gacccccagg ttccactctt gtcacccatg gctcagacat gcttagagga
      601 accacagcca tcaacatcga catcagacct ccttcccacg gcctctacct cttctacgga
      661 gccagagctg acctctgcag ggcaaaagca ttcctctagc tctggacctg ggactataag
      721 catctcccca aaagaatgta gttcacttgt tgcaaatggt gaactctcta gcctttcttc
      781 agttttccaa gacaacgaag catccttttc tttgttgaaa accgaagaca ctgaggaatt
      841 ggagcctgcc aaaaaaaaga tgaaaggaga tggggagctt gacttgaacc tccagttatc
      901 agttgcagac cagcgtggaa ttgcccaaac ctcaagtgag gatgtcaaag atgcctctgt
      961 gaaaccagac aagatggagg agacactaac ctgtatcatc tgtcaagacc ttctgcatga
     1021 ctgtgtgagt ttgcagcctt gtatgcacac attttgtgcg gcttgctact ctggttggat
     1081 ggagcgttca tctctgtgcc ctacctgccg atgtccagtg gagcggattt gcaaaaacca
     1141 catcctgaac aaccttgtgg aagcatacct tctccagcac ccagataaga gtcgcagtga
     1201 agaagatgtg agaagtatgg atgcaaggaa taaaatcact caagatatgc tgcaacccaa
     1261 agtcaggagg tctttctctg atgaagaggg gagttcagag gacctgctag agctgtctga
     1321 tgttgatagt gaatcctcag acatcagtca gccatacatt gtatgcagac agtgtcctga
     1381 atacagaagg caagcagtgc agtctcttcc ttgcccagtc ccagagagtg agctgggagc
     1441 cacacaggcc cttggtgggg aagcaccttc aacatctgcc agcttgacaa caggtgcagt
     1501 gtgcctgcag cccttctgcc acctgtactg gggctgcacg cgaactggct gctttggctg
     1561 cttggcccca ttctgtgagc tcaacctggg ggacaagtgt ttggatggag tgctgaacaa
     1621 taacaattat gagtcggata tcctgaagaa ttacctgaca accaggggtc tgacatggaa
     1681 aaatatgttg acagagagtc tcctggctct acagcggggt gtatttatac tgtctgatta
     1741 cagaatcact ggaaacaccg tgctgtgtta ctgctgtggt ctgcgtagct tccgagagct
     1801 gacctatcag tatcgtcaga acattcctgc ttcagagttg ccagtgaccg taacatcccg
     1861 tcctgattgc tactggggcc gcaactgtcg cactcaggtg aaggctcacc atgcaatgaa
     1921 attcaatcac atctgtgagc aaacaaggtt caagaactaa atattggagg agacacatga
     1981 aacagttaca gagcacagga ggcaatgata ctatggtttt tttttttaaa taccatgtac
     2041 atttttacgg ttttccctaa gcagcactga ggtttctggt cagactctct ggtgtggcga
     2101 gctttatctt cagtcacaca cacacacaca cacacacaca ctctacatgc cccactaacc
     2161 tgggaggcct actggccaca ctggccttct agtcagtgtg agaggatgag cagactgaga
     2221 tcccccctcc cactagacag ctctcccttc ctgtgtggtg gggcagtgac agtgcaggtt
     2281 tgcaggtttg caggtttgta cttctgtgtc ttttctacct tgtaccttga ctacagttaa
     2341 atgggaaagt ttgtgggaaa agctgtcaga tatgttagaa acattctccg gaaggaaagg
     2401 aagcatacgt ttacagcctc cagggatgta taggatattc ttctgtctga aaagacacag
     2461 ccttttgtat attttttatt ttaataagtt tggtggtgct tatcttctaa taagatttaa
     2521 atattaaaaa ctgtagcaca aatactataa tttataattt acaaattgac taaaattagg
     2581 aatagcctga catttggaag aatgagcata tgtttttgtt tatttaaaaa cttatcaaat
     2641 gtccaaaact gctaatcctg gggaggatgt cttgagtatc caggtccttg acacagggct
     2701 ggccaatgcc tcttgtccag caggccaagc ccttagccct ccagtccctg agagcaactc
     2761 cctgctgaag ctccagatgg ctccagactg acagggcctt gcttctccag ccctgatctg
     2821 gtacattatt aggtttgcca tgtcatctgg aataatactt gaaattttgt tcttagtttt
     2881 ttttaaactt tttatctttt attgaaatca cctgttatat ttgtttgcaa actggtaact
     2941 ttttgcttct caggaataca attttcaact gttgtcttgc tcttgatata gactgagagg
     3001 cagtactctg tgtttgtggg agatggttct ctttttttaa ttctaataaa tgagctgtgt
     3061 ttgtttctct t
//
LOCUS       NM_001371633            5036 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sarcalumenin (Srl), transcript variant 1, mRNA.
ACCESSION   NM_001371633 XM_003750771
VERSION     NM_001371633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   Zhao,X., Yoshida,M., Brotto,L., Takeshima,H., Weisleder,N.,
            Hirata,Y., Nosek,T.M., Ma,J. and Brotto,M.
  TITLE     Enhanced resistance to fatigue and altered calcium handling
            properties of sarcalumenin knockout mice
  JOURNAL   Physiol Genomics 23 (1), 72-78 (2005)
   PUBMED   15998745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001371633.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.25364.1,
                                           SRR26643295.37071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000010.1  11540449-11540519
            72-1364             JAXUCZ010000010.1  11566075-11567367
            1365-1466           JAXUCZ010000010.1  11570085-11570186
            1467-1562           JAXUCZ010000010.1  11572156-11572251
            1563-1679           JAXUCZ010000010.1  11576819-11576935
            1680-1913           JAXUCZ010000010.1  11578034-11578267
            1914-5036           JAXUCZ010000010.1  11581384-11584506
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5036
                     /gene="Srl"
                     /note="sarcalumenin"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
     exon            1..71
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2725
                     /gene="Srl"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="sarcalumenin isoform 1 precursor"
                     /protein_id="NP_001358562.1"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
                     /translation="MKALLLLCCFLASLLLSGQAELQVSASGGTEDVGNLLENHFSAG
                     DASLEEKERALYADAAPGDKNLLLHYPDGREAESFEQPPAGAPSTANGQGSESEASLS
                     NSSAAESAPPGDVEGPGEEEEGPHAAGTLPPGGAEGPEERPEFSSGEEAGQEEAGVGL
                     PTEGAANMEAEAQEELQGRLGDGPMEEAAAGAAEPVAPQSTEGEEAEGEGSIGSDHQS
                     TELDGAQDAIPAGEDSDADVAAEAREEAEDQPEDHSLPSEDAAPPGPDHQPTDPHAVS
                     DMASSEVGAEEDAEDSKAEVDAETGEEAEDQGEPRPSLEAGSAREASEKSEDTQSSEV
                     RETEGQASGMSEEDLAEASSEEEGGEEDGRENGGLPSKEESGEDSGDGASSEEEGSTS
                     GEAAEPQKTPRATGHEEEGAQLDVEDLNTGSEGVKTQDTEAEASEERQQGRGNPVIAH
                     QEEAEDVSEEAPMRDRSHIEKTLMLNEDKPADDYSAVLQRLRKIYHTSIKPLEQSYKY
                     NELRQHEITDGEITSKPMVLFLGPWSVGKSTMINYLLGLEDTRYQLYTGAEPTTSEFT
                     VLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPG
                     IIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIR
                     IILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQDYKPDTHRDLFLK
                     EEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELV
                     FKDIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISNFKLLSQQCSYMGG
                     CFLEKIERAITQELPSLLGSIGLGKNPGAPNCDKTGCGETPKNRYKKH"
     sig_peptide     11..70
                     /gene="Srl"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <236..937
                     /gene="Srl"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <236..937
                     /gene="Srl"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <821..>1459
                     /gene="Srl"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    <821..>1459
                     /gene="Srl"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    1478..1576
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    1478..1576
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    1586..2311
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    1586..2311
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    1601..1624
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1601..1624
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1616..1627,1871..1873,2069..2071,2075..2077,
                     2177..2185)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    order(1616..1627,1871..1873,2069..2071,2075..2077,
                     2177..2185)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    1694..1696
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1694..1696
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1706..1714
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    1706..1714
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    1871..1882
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1871..1882
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1877..1882,1958..1963)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1877..1882,1958..1963)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    2066..2077
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2066..2077
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2177..2185
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2177..2185
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     exon            72..1364
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1466
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1562
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1679
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1913
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..5036
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtcacc atgaaggcgc tgctcctgct ctgctgcttc ctggcctcgc tgctgctttc
       61 aggacaagca gaactgcaag tctctgcttc gggtggcacg gaagatgttg gcaatttgtt
      121 ggagaatcat ttctctgctg gagacgcaag tctagaggag aaagaaaggg cgctttatgc
      181 agatgcggcc cctggagaca agaacctact ccttcactac ccagacggca gggaggctga
      241 gagcttcgag cagcctcctg caggggcccc ttccactgcc aacggccagg gctccgaatc
      301 cgaagctagc ctgtccaatt cctcagctgc agagtcagct ccacccgggg atgtcgaagg
      361 gcccggggag gaagaggagg gcccacatgc agcaggcacc cttcctccgg gaggggctga
      421 ggggccagaa gagaggccag agttcagttc tggagaggaa gcaggacagg aggaggctgg
      481 ggtggggctc cccacagagg gggctgcgaa tatggaggca gaagcacaag aggaattgca
      541 ggggcgctta ggagatgggc ctatggaaga agcagcagcc ggggcagcag agcctgtagc
      601 tccccagtcc acagagggtg aagaggcaga aggtgagggc agcataggct ctgatcacca
      661 atccacagag ctagatggag cccaggatgc catacccgct ggagaggact cagacgctga
      721 cgtggctgcc gaagccaggg aggaggcaga ggaccagccc gaggaccact ccctgccgtc
      781 agaggatgcc gcacccccag ggcctgatca ccagcccaca gacccacacg cagtctctga
      841 catggcatct tccgaagtag gggcagagga agacgctgaa gactcaaagg ctgaggtgga
      901 tgcagaaact ggggaggagg ctgaggacca gggggagcct agacctagcc tggaggctgg
      961 ctcagctaga gaggccagtg aaaagtccga ggacacccag agttccgagg tgagggagac
     1021 agagggccag gcatcaggga tgtcggagga ggacctggct gaggcctcct ctgaagaaga
     1081 gggcggtgaa gaagatggaa gggagaatgg aggacttcca tctaaagaag agtctggaga
     1141 agacagtggt gacggagcta gctcagaaga agaggggagc acctccgggg aggctgcaga
     1201 gccccagaaa acaccaagag ccacaggaca tgaggaggaa ggggcccagc ttgatgtgga
     1261 agatttgaac acagggtccg agggcgtcaa gacccaggac acagaagcag aggcatctga
     1321 agagagacaa caggggagag ggaatcctgt aattgctcat caggaagagg cggaggatgt
     1381 gagcgaagag gctcccatga gggatcgctc ccacatcgag aaaaccctga tgctgaatga
     1441 ggacaagcca gcggacgatt actcagcggt gctgcagcgg cttcggaaga tctaccacac
     1501 atccatcaag cccctggagc agtcttacaa gtacaatgaa cttcgacagc atgagatcac
     1561 agacggggag attacttcca agccaatggt gctgttcctg ggaccgtgga gcgttggcaa
     1621 atccaccatg ataaactacc tccttggatt agaagatact cgataccagc tttatacagg
     1681 tgctgaacct accacctctg agttcactgt cctcatgcat gggcccaagc tgaaaaccat
     1741 tgagggcatc gtcatggctg ctgacagtgc ccggtccttc tcaccactgg aaaagtttgg
     1801 ccagaatttt ctggagaagc tgattggcat tgaggttccc cacaagcttc tagaacgagt
     1861 cactttcgtg gatactccgg gcatcattga gaaccgcaag caacaagaaa gaggttaccc
     1921 cttcaacgat gtgtgtcagt ggttcatcga cagagccgac ctcatcttcg ttgtctttga
     1981 tcccaccaag ctggacgtgg gcctggagct ggagatgctc ttccgacaac taaaaggacg
     2041 cgagtcccag ataaggatca ttttgaacaa ggctgacaac ctggccacac aaatgctcat
     2101 gcgggtgtat ggggctctct tctggagctt ggcccctctc atcaatgtca cggagcctcc
     2161 ccgggtttac gtcagctcct tctggccaca ggactataag cccgataccc accgggatct
     2221 gttcctcaaa gaagagatct ctctcctgga agacctgaac caggtgatag agaacaggct
     2281 cgagaacaag attgctttta ttcgccagca cgccatcagg gtccgaatcc acgccctttt
     2341 agttgaccgc tatctgcaga cttacaagga caaaatgacc ttcttcagtg acggggaact
     2401 ggtctttaag gacattgtgg aagatcctga taaattctac atcttcaaga ccatcctggc
     2461 aaagaccaat gtcagcaagt ttgaccttcc caaccgtgag gcttataagg acttctttgg
     2521 catcaacccc atttccaatt tcaaactcct ctctcagcag tgctcctaca tggggggctg
     2581 cttcctggag aagattgaac gagccatcac ccaggagctc cccagccttc tgggtagcat
     2641 tgggcttggg aagaatccag gtgctcctaa ctgtgacaaa acaggctgtg gagagacccc
     2701 aaagaatcgc tacaagaagc actagtttct gcgtagctat cctcgggtcc ccgttggtga
     2761 ataagcttgc gtcctaactg tctgagaagt cctggtttgt taaccctttg agccatactg
     2821 gcgacaacca gtctgcattg gagatttgga agttcactga ggccggtgaa tcagggaagg
     2881 cacagggttc tagggaggag agcggtaact gtgaatcata gtgtgcttgt cctactgctt
     2941 cagttagaag gcctgacaca ggccaagtca gtctacaaag cttcccttgt tttttctggg
     3001 tcctgtcttg gaagggcaga gagcagctaa atcctaatga atactaagat agtgaggttc
     3061 taataagcta aactcatgga aatttcctga gtaacagagg cttctcaggt ctgtgtcaac
     3121 tcctttcaca cacgtcttct gtttgatccc tgtccctcct tggctccctc ctaagcttgg
     3181 gttgattttc agaagtggac agtctcttga gtttgatctt catgaatttt gagcctaacc
     3241 ttggaatcct ctcccagttt tctcaagggg cggggcatcc ataaacctaa aacaagagtt
     3301 tttaaattag ggtgttgatc tgccgccact ggtgtcccaa ttggggatct cagacagttg
     3361 tccctaaaag gagggtgagt gggtgatgta ctcaagtacc ttcccctcct tacacggagg
     3421 tatgaagggc tccgggggtt aattggtttg cagtgtgtct ttgtctgttg catgtcttgg
     3481 aaagctcaga tcacagaggt gttgggtttc agagtggaca atggagacct tgctcctagt
     3541 ccttagaggg ttctctggac agacattctc ccaagttttg gtggaagctg tttctacagc
     3601 ttctttgtgg gagcacttga cagaggactt gcctcctctg gttcccagaa ccatggtttc
     3661 tcttttcctt tcttctccat tccctgatgc atcaatactt ccaactgaga aaaagtccct
     3721 cggatcagaa ccagtaccag ccccttgaca ttggcattgg tgccagataa ggcctgaggt
     3781 tagattcaaa ctgaattcct gcagataccc accgagtgca gtcaggactg tcaaggcctt
     3841 caaacaccag tgaatgtgca cttagtgtgt ccactgtaca agagacagcc cggaggatga
     3901 cagatttgag ggcacagaga gaggactcct gggagtcgtg caaggcacac atacactgcc
     3961 accttgaagt gcaggagagc aagacgctct ggaagggtga agagcttttt gatggagcag
     4021 gcaaggtgaa gttcagcctg ccttgagggc ttcctctggg cacagccagc tgctttcgtt
     4081 ttggagcaac ctctcctgga ggccttgatt gtgaggcatg ggttgggatc cagcagcagc
     4141 agggtgtcat ctggagcaga agggaagtgg gagggaaggc tgagccaacg ttattctttc
     4201 tgaggatcaa atatgcagcg taagcatatt ggtaaccgag gaggctacac agagaacatc
     4261 aactgagggg tttgtgtttc tccgaattct ttgaagtctg gtgccttcta aggaaggctg
     4321 ctgttttggc tcctcgtagg gcccaggacc tgctgccgta agtcaaaagc tccagaactg
     4381 ccaggacagt gtctccaagg aatgagttcc tcccataagg gtcattcatg gagcttggtg
     4441 gctagggtag atgagctgca atctgtcttg ggtttttctt cccaaactcc tcccctcttc
     4501 tctccatcat gcgctctctg gagagactgt ccctcccacc cttctccttc ctgcccctca
     4561 tgcctgtgag ttttgtgtgg caaatctgtt tttctctcaa tgcagaaacg ggggaaaaag
     4621 ctgaactgta tggagcctgt cctagctgtc agtgcctgca tgcttcgggg gaagcaggtg
     4681 aaatgaggcc aatgaattct tacagcattt gcgtttgggg ggaggcacct gactagtggt
     4741 accttccttc cttttggatt tctctccatc catttcttct ctgcctccat tctgtctctc
     4801 tcccactcac aggccgctga cagtcccaca gctttcagca ctcaatcttt gcctggccgt
     4861 gcagagctgg gttttgagca ggattctgac taggaggagg gaaaaacgtg ggatgcagag
     4921 atttcctgag gggaacatct gtgtctgtgc ctgaagagtg gctgaccttt ccagtgtcct
     4981 ttctattctg atttcatcag ggagaacgtc tcaataaagt tccaatctct cttcaa
//
LOCUS       NM_001437322            3779 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sarcalumenin (Srl), transcript variant 3, mRNA.
ACCESSION   NM_001437322 XM_063268901
VERSION     NM_001437322.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Zhao,X., Yoshida,M., Brotto,L., Takeshima,H., Weisleder,N.,
            Hirata,Y., Nosek,T.M., Ma,J. and Brotto,M.
  TITLE     Enhanced resistance to fatigue and altered calcium handling
            properties of sarcalumenin knockout mice
  JOURNAL   Physiol Genomics 23 (1), 72-78 (2005)
   PUBMED   15998745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063268901.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.25368.1,
                                           SRR26643295.37073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000010.1  11540449-11540519
            72-173              JAXUCZ010000010.1  11570085-11570186
            174-269             JAXUCZ010000010.1  11572156-11572251
            270-305             JAXUCZ010000010.1  11574315-11574350
            306-422             JAXUCZ010000010.1  11576819-11576935
            423-656             JAXUCZ010000010.1  11578034-11578267
            657-3779            JAXUCZ010000010.1  11581384-11584506
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3779
                     /gene="Srl"
                     /note="sarcalumenin"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
     exon            1..71
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1468
                     /gene="Srl"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="sarcalumenin isoform 3 precursor"
                     /protein_id="NP_001424251.1"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
                     /translation="MKALLLLCCFLASLLLSGQAEEAEDVSEEAPMRDRSHIEKTLML
                     NEDKPADDYSAVLQRLRKIYHTSIKPLEQSYKYNELRQHEITVLGMAPRALSILDGEI
                     TSKPMVLFLGPWSVGKSTMINYLLGLEDTRYQLYTGAEPTTSEFTVLMHGPKLKTIEG
                     IVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQERGYP
                     FNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADNLATQM
                     LMRVYGALFWSLAPLINVTEPPRVYVSSFWPQDYKPDTHRDLFLKEEISLLEDLNQVI
                     ENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFKDIVEDPDKFYI
                     FKTILAKTNVSKFDLPNREAYKDFFGINPISNFKLLSQQCSYMGGCFLEKIERAITQE
                     LPSLLGSIGLGKNPGAPNCDKTGCGETPKNRYKKH"
     sig_peptide     11..70
                     /gene="Srl"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    185..268
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    185..268
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    329..1054
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    329..1054
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    344..367
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    344..367
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(359..370,614..616,812..814,818..820,920..928)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    order(359..370,614..616,812..814,818..820,920..928)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    437..439
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    437..439
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    449..457
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    449..457
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    614..625
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    614..625
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(620..625,701..706)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(620..625,701..706)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    809..820
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    809..820
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    920..928
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    920..928
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     exon            72..173
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            174..269
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            270..305
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            306..422
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            423..656
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            657..3779
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtcacc atgaaggcgc tgctcctgct ctgctgcttc ctggcctcgc tgctgctttc
       61 aggacaagca gaagaggcgg aggatgtgag cgaagaggct cccatgaggg atcgctccca
      121 catcgagaaa accctgatgc tgaatgagga caagccagcg gacgattact cagcggtgct
      181 gcagcggctt cggaagatct accacacatc catcaagccc ctggagcagt cttacaagta
      241 caatgaactt cgacagcatg agatcacagt tctggggatg gcacccaggg ccttgagcat
      301 cctagacggg gagattactt ccaagccaat ggtgctgttc ctgggaccgt ggagcgttgg
      361 caaatccacc atgataaact acctccttgg attagaagat actcgatacc agctttatac
      421 aggtgctgaa cctaccacct ctgagttcac tgtcctcatg catgggccca agctgaaaac
      481 cattgagggc atcgtcatgg ctgctgacag tgcccggtcc ttctcaccac tggaaaagtt
      541 tggccagaat tttctggaga agctgattgg cattgaggtt ccccacaagc ttctagaacg
      601 agtcactttc gtggatactc cgggcatcat tgagaaccgc aagcaacaag aaagaggtta
      661 ccccttcaac gatgtgtgtc agtggttcat cgacagagcc gacctcatct tcgttgtctt
      721 tgatcccacc aagctggacg tgggcctgga gctggagatg ctcttccgac aactaaaagg
      781 acgcgagtcc cagataagga tcattttgaa caaggctgac aacctggcca cacaaatgct
      841 catgcgggtg tatggggctc tcttctggag cttggcccct ctcatcaatg tcacggagcc
      901 tccccgggtt tacgtcagct ccttctggcc acaggactat aagcccgata cccaccggga
      961 tctgttcctc aaagaagaga tctctctcct ggaagacctg aaccaggtga tagagaacag
     1021 gctcgagaac aagattgctt ttattcgcca gcacgccatc agggtccgaa tccacgccct
     1081 tttagttgac cgctatctgc agacttacaa ggacaaaatg accttcttca gtgacgggga
     1141 actggtcttt aaggacattg tggaagatcc tgataaattc tacatcttca agaccatcct
     1201 ggcaaagacc aatgtcagca agtttgacct tcccaaccgt gaggcttata aggacttctt
     1261 tggcatcaac cccatttcca atttcaaact cctctctcag cagtgctcct acatgggggg
     1321 ctgcttcctg gagaagattg aacgagccat cacccaggag ctccccagcc ttctgggtag
     1381 cattgggctt gggaagaatc caggtgctcc taactgtgac aaaacaggct gtggagagac
     1441 cccaaagaat cgctacaaga agcactagtt tctgcgtagc tatcctcggg tccccgttgg
     1501 tgaataagct tgcgtcctaa ctgtctgaga agtcctggtt tgttaaccct ttgagccata
     1561 ctggcgacaa ccagtctgca ttggagattt ggaagttcac tgaggccggt gaatcaggga
     1621 aggcacaggg ttctagggag gagagcggta actgtgaatc atagtgtgct tgtcctactg
     1681 cttcagttag aaggcctgac acaggccaag tcagtctaca aagcttccct tgttttttct
     1741 gggtcctgtc ttggaagggc agagagcagc taaatcctaa tgaatactaa gatagtgagg
     1801 ttctaataag ctaaactcat ggaaatttcc tgagtaacag aggcttctca ggtctgtgtc
     1861 aactcctttc acacacgtct tctgtttgat ccctgtccct ccttggctcc ctcctaagct
     1921 tgggttgatt ttcagaagtg gacagtctct tgagtttgat cttcatgaat tttgagccta
     1981 accttggaat cctctcccag ttttctcaag gggcggggca tccataaacc taaaacaaga
     2041 gtttttaaat tagggtgttg atctgccgcc actggtgtcc caattgggga tctcagacag
     2101 ttgtccctaa aaggagggtg agtgggtgat gtactcaagt accttcccct ccttacacgg
     2161 aggtatgaag ggctccgggg gttaattggt ttgcagtgtg tctttgtctg ttgcatgtct
     2221 tggaaagctc agatcacaga ggtgttgggt ttcagagtgg acaatggaga ccttgctcct
     2281 agtccttaga gggttctctg gacagacatt ctcccaagtt ttggtggaag ctgtttctac
     2341 agcttctttg tgggagcact tgacagagga cttgcctcct ctggttccca gaaccatggt
     2401 ttctcttttc ctttcttctc cattccctga tgcatcaata cttccaactg agaaaaagtc
     2461 cctcggatca gaaccagtac cagccccttg acattggcat tggtgccaga taaggcctga
     2521 ggttagattc aaactgaatt cctgcagata cccaccgagt gcagtcagga ctgtcaaggc
     2581 cttcaaacac cagtgaatgt gcacttagtg tgtccactgt acaagagaca gcccggagga
     2641 tgacagattt gagggcacag agagaggact cctgggagtc gtgcaaggca cacatacact
     2701 gccaccttga agtgcaggag agcaagacgc tctggaaggg tgaagagctt tttgatggag
     2761 caggcaaggt gaagttcagc ctgccttgag ggcttcctct gggcacagcc agctgctttc
     2821 gttttggagc aacctctcct ggaggccttg attgtgaggc atgggttggg atccagcagc
     2881 agcagggtgt catctggagc agaagggaag tgggagggaa ggctgagcca acgttattct
     2941 ttctgaggat caaatatgca gcgtaagcat attggtaacc gaggaggcta cacagagaac
     3001 atcaactgag gggtttgtgt ttctccgaat tctttgaagt ctggtgcctt ctaaggaagg
     3061 ctgctgtttt ggctcctcgt agggcccagg acctgctgcc gtaagtcaaa agctccagaa
     3121 ctgccaggac agtgtctcca aggaatgagt tcctcccata agggtcattc atggagcttg
     3181 gtggctaggg tagatgagct gcaatctgtc ttgggttttt cttcccaaac tcctcccctc
     3241 ttctctccat catgcgctct ctggagagac tgtccctccc acccttctcc ttcctgcccc
     3301 tcatgcctgt gagttttgtg tggcaaatct gtttttctct caatgcagaa acgggggaaa
     3361 aagctgaact gtatggagcc tgtcctagct gtcagtgcct gcatgcttcg ggggaagcag
     3421 gtgaaatgag gccaatgaat tcttacagca tttgcgtttg gggggaggca cctgactagt
     3481 ggtaccttcc ttccttttgg atttctctcc atccatttct tctctgcctc cattctgtct
     3541 ctctcccact cacaggccgc tgacagtccc acagctttca gcactcaatc tttgcctggc
     3601 cgtgcagagc tgggttttga gcaggattct gactaggagg agggaaaaac gtgggatgca
     3661 gagatttcct gaggggaaca tctgtgtctg tgcctgaaga gtggctgacc tttccagtgt
     3721 cctttctatt ctgatttcat cagggagaac gtctcaataa agttccaatc tctcttcaa
//
LOCUS       NM_001437232            1448 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 9 open reading frame
            153 (C17h9orf153), transcript variant 4, mRNA.
ACCESSION   NM_001437232 XM_063276010
VERSION     NM_001437232.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063276010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2238807.1,
                                           SRR26360181.350186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000017.1  4980936-4981000
            66-248              JAXUCZ010000017.1  4981452-4981634
            249-344             JAXUCZ010000017.1  4985033-4985128
            345-834             JAXUCZ010000017.1  4986300-4986789
            835-871             JAXUCZ010000017.1  4987547-4987583
            872-1448            JAXUCZ010000017.1  4987712-4988288
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1448
                     /gene="C17h9orf153"
                     /note="similar to human chromosome 9 open reading frame
                     153"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
     exon            1..65
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            66..248
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    210..212
                     /gene="C17h9orf153"
                     /note="upstream in-frame stop codon"
     exon            249..344
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..905
                     /gene="C17h9orf153"
                     /note="isoform 2 is encoded by transcript variant 4;
                     uncharacterized protein C9orf153 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153 homolog isoform
                     2"
                     /protein_id="NP_001424161.1"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
                     /translation="MSSTRHHTWTRGSIGSLYLHRCSLPELYASLEIFNKESKKSNLQ
                     KICGMSFKEAQEVLWKILGGLISDSYDTVKGDERHPSIPVNKEERKTPSMSDLLHQSL
                     LKGYNVPLEQVHSSQQRLAQVGIPPPPLSFPHGLSNELPVILPAQHFRKRIQSVTFRK
                     LLLSSVAPGRLFYEEKPTSQQVSFDPGKQFLDLADLQWSSQDSDGLPSS"
     misc_feature    276..551
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     misc_feature    276..551
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     exon            345..834
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            835..871
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1448
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgagcct gcggtctacc aggtgaagga tactcagcct gggacttcag agattaccca
       61 caaagagcta gtgctcatga gaaagctacc tcctttgaac catgatggaa tatgatttgt
      121 gaacaatgaa aagatgtgta aggtcaaact gggttccaac ctacgctgct gggatgaact
      181 ctccctgcca cagcgggcct ggcaatcctt aaggacacca cccatccaac caagacgtcc
      241 ctaagcagga acgtggaggt tcagatcttg gcacaatgtc ctccaccaga caccacactt
      301 ggacccgagg cagcatagga tccctgtatc tgcaccgttg ttcgctacca gaattatatg
      361 catcacttga gatttttaat aaggagagca agaaatctaa tctccaaaag atctgtggca
      421 tgtcgtttaa ggaagctcag gaagtccttt ggaaaatcct gggtggcctg atctctgaca
      481 gctatgacac cgtaaaaggg gatgagcgcc acccttccat accggttaac aaagaggagc
      541 ggaagacacc atctatgtca gatctacttc accaaagtct gttaaagggt tacaatgttc
      601 cgttggagca ggtacacagc tcccagcaga ggctggccca ggtgggcatc cctcctcctc
      661 cactctcctt tcctcacggt ttaagcaacg aactgcccgt gatccttcca gcacagcact
      721 tcaggaaaag gattcaaagc gtcacattcc gcaaacttct cctgtcttct gttgccccag
      781 gcaggctgtt ctatgaagaa aagccaacaa gccaacaagt ctcctttgac ccaggaaagc
      841 agttcctaga cctggcagac cttcagtgga gttcgcaaga ctctgatggt ctaccctcaa
      901 gctgagtatg ataaagaagg acagctttat ctcacctgga aaatagtgta ctgaaatagt
      961 ctggatatga accgttctgc ttgggattgc cgaaccaaca caagaggtgg aaaagcacac
     1021 agcccacttc tctactcaat gtccgtgcaa agcctacatt aaaatgattt cgtggaggaa
     1081 catgtccaac caatctgctg gcattactct ggttcacagt tctgatgctc atctgaacag
     1141 caggtgaagg gaatactggg tggatacaca gaaatagctc tccaccaaaa atggatctct
     1201 acaatgtttt cttccttggt ttctctgttt ctttgtttct ggtttgttta tttgtttgtt
     1261 tgtttgttta ctttttgctg tcaatatgta atttacttac ttaaaaaaat ccaaattctg
     1321 gcattgtcta gaaaatttca gtaggtttta aagttgaact gttgaaatgt gttcacggaa
     1381 gcattctgct tgcattaatg ctttacacgg tgcatgtata ttaaaagtca cacccaaatg
     1441 aacgtgga
//
LOCUS       NM_001106147            4246 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 1, mRNA.
ACCESSION   NM_001106147 XM_001053970 XM_225947
VERSION     NM_001106147.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001106147.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1395623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000018.1  41099398-41099702   c
            306-540             JAXUCZ010000018.1  41084042-41084276   c
            541-866             JAXUCZ010000018.1  41075830-41076155   c
            867-1013            JAXUCZ010000018.1  41073397-41073543   c
            1014-1109           JAXUCZ010000018.1  41065895-41065990   c
            1110-1363           JAXUCZ010000018.1  41061600-41061853   c
            1364-1488           JAXUCZ010000018.1  41061277-41061401   c
            1489-1779           JAXUCZ010000018.1  41059874-41060164   c
            1780-2077           JAXUCZ010000018.1  41049807-41050104   c
            2078-4246           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4246
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..305
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Trim36"
                     /note="upstream in-frame stop codon"
     CDS             243..2432
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 1"
                     /protein_id="NP_001099617.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MSESGEMSEFGYIMELLAKGKVTIKNIEKELICPACKELFTHPL
                     ILPCQHSVCHKCVKELLLSLDDSFNDVASDSSNQSSPRLRLTSPSMDKIDKINRPGWK
                     RNSLTPRPTMFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLC
                     KPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEHETE
                     RINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKS
                     QISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHT
                     QMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQAS
                     FEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKADSYVL
                     EYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELVLHT
                     PPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIG
                     DVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSE
                     DAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYD
                     MDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV"
     misc_feature    324..617
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    324..617
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    693..857
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    693..857
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    870..1004
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    870..1004
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    1008..1382
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1008..1382
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1317..1463
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1317..1463
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1533..1724
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1533..1724
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1788..2399
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     misc_feature    1788..2399
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     exon            306..540
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            541..866
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1013
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1109
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1363
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1488
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1779
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2077
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..4246
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccgttag ctggctctgg ccaacctgat gcagccagga ccccggaggc tggacaaggc
       61 tgcccgggtc ctcctgggcc tgcatcccac ccagccccgc ccttgtcttt cccttctcca
      121 cttttaaccg tgcctctgga ggagggctgg gcaaactcaa gctgaacaga gagaaaggcg
      181 gagaaaggac cacattcgat gagccggtct ggctggtcca tagttcataa agggtcttga
      241 ccatgtcgga gtcaggggag atgagtgaat ttggctacat tatggaattg cttgccaagg
      301 gcaaggtgac tatcaagaat atcgaaaagg agcttatttg cccagcatgc aaggagctgt
      361 ttacacaccc gctgatcctt ccctgccagc acagcgtctg tcataaatgt gtgaaagaac
      421 tcttactgtc tcttgatgac tcattcaacg atgtggcgtc agacagctct aatcagagca
      481 gccctcggct ccggctcacc tcccccagca tggataaaat cgacaagatt aacagaccag
      541 gctggaagcg taattcactg acccccagac caaccatgtt tccttgtcct ggctgcgagc
      601 atgatgtgga tcttggagag cgaggagtca gtggtctgtt tcgaaatttc actttggaaa
      661 cgattgtcga gaggtaccgg caggctgcta gggcagccac agccattatg tgtgaccttt
      721 gtaaaccacc accccaggaa tctacaaaga gctgcatgga ttgtagtgca agctactgca
      781 acgaatgctt caaaatttat catccctggg gcacggtaaa agcccagcat gagtatgtgg
      841 gccccaccac taatttcaga cccaagattt taatgtgccc agaacatgag acagagagaa
      901 taaacatgta ctgtgaactg tgcaggagac cggtttgcca cctctgtaag ttgggtggga
      961 atcattccaa tcaccgggta accaccatga gcagtgccta caaaacatta aaggagaaac
     1021 tttcaaaaga cattgatttc cttattggta aggaaagcca ggtgaagagt caaatttctg
     1081 aactaaactt gttaatgaaa gaaacagagt gcaatggaga gagggcgaag gaagaagcgc
     1141 tggcacattt tgagaagctc tttgaaatcc tggaagacag gaagtcgtct gttctgaaag
     1201 ccatagatgc ctctaagaaa ctaagactag ataaatttca cactcaaatg gaagagtacc
     1261 aaggccttct agagaataac gggcttgtgg gatatgctca ggaagtgctg aaggagacgg
     1321 atcagtcttg ctttgtgcag acagcaaagc agctccatct cagaatacag aaagctacag
     1381 aatccctgaa gagctttaga cctgcagccc aggcttcttt tgaagactat gttgttaaca
     1441 tttcgaaaca aacagaggtg cttggagaat tgtccttttt ctctagtggc atagacattc
     1501 ctgagatcaa cgaggaacag agtaaagtgt ataataatgc cctgatagac tggcaccatc
     1561 cagaaaagga caaagccgac agctatgttc tcgaataccg caagattaat agagacgaag
     1621 aaatgatatc ctggaatgag atagaagttc atggcacaag taaagttgtc tccaatcttg
     1681 aaagcaacag tccctatgcg ttccgagtga gagcttacag gggttctatc tgcagtccct
     1741 gcagtcgaga actggttctg catactcctc cagctccagt tttcagtttc ctgtttgatg
     1801 aaaagtgtgg ctacaatact gagcatctct tgctgaacct gaagagagac cgggtagaaa
     1861 gcagagctgg atttaatgtc ctcctcgctg cggaacgcat ccaagtgggc cattacacaa
     1921 gcttagacta catcatcggg gatgtcggaa tcacgaaagg taaacacttc tgggcctgcc
     1981 gtgtggaacc gtattcatac ctggtgaaag tgggagttgc ttccagtgac aaactgcaag
     2041 agtggctgcg ctctccccgg gacgcagcta gtccaagata tgagcaagac agtgggcatg
     2101 acagcggaag tgaggacgcc tattttgatt cttcacaacc gtttacatta gttactatag
     2161 gcatgaagaa attttttata cccaagtcac ctacttcttc taatgaaccc gaaaacagag
     2221 ttctccccat gccaacaagt atagggattt tccttgactg tgataaaggc aaagtgagct
     2281 tctatgatat ggaccacatg aaatgcctat atgagcgcca ggtggactgt tcacacacaa
     2341 tgtaccccgc ttttgcgtta atgggcagtg gcgggatcca gcttgaggaa accatcaccg
     2401 cgaagtatct ggaatatgaa gaggatgtgt agcttggaca ccccacagga cgaggatcag
     2461 aactgtgaac aaagccatgc cgtggtgtta gagtcttcgt aactaattac atatcattta
     2521 cgtctctgtc accacacctg tttgtactgt gtgattcttt gttttgtttt gttctgcttt
     2581 gacacacaca gtctcagtgt gtagtccagg ccagcttcaa actctgttct gttatagcct
     2641 ccttaggggc tgggattata ggcaggcacc accataccca gctagtgtat gattcacaac
     2701 ttttttcatg tcataatggt cttacctttt acaaatggtg ggagtagaga cttgtcttaa
     2761 ctggtccagg atagataact ctacaatgga agtccttctc tttggggaca aggactctaa
     2821 ttgatgtaag tcagctgatg gtggtattat tcctgtccct ttgtttgggg gttgcagtgg
     2881 gatacaaagt atttacaaag ttctttgtgc ttgttttctt ctttcctttt cattgtgtat
     2941 catgttcatg tccaaagaga agatattttt aaatgtttat cgatagaaat tagtactaag
     3001 ccatgtgtct tgcatttgat gttaatagga aaataaattt acagataggt aaaatgatga
     3061 aggccataaa atggtagtat atttaagtag aaaattatgt attttaaagt gtgtaactac
     3121 tgagtgtata ttgcctggca aacgaatact gctttttccc tctatagacc acagactgta
     3181 ttggtaagaa tatctctaag agtgtctttg ctgtagtgcc cattgtcctg tacatgtagc
     3241 aagcatcgtt tcatataaga aacacagggt tcttgaaccc atgcgacttt ccactacaat
     3301 agaattcttt ttcaggaaat tttattttca aattttctta ttttagaaaa tactcattta
     3361 tagcaaagaa ttatttttca gaaatactag ggaagatgga ctgatagtga acacctatct
     3421 ttttgtgtct tgtgaacttt atgattttgg tacatatgtt atacatcagg gttttctggc
     3481 ttttgtttac agatttgaga agtttgctgt ccattttcag cgttgttgaa tgccagacat
     3541 gttacatgtt actactgtcc acttggatgg cactgtttgt gggctcattg tgtggtcata
     3601 agcatttgta gtgtgaatca gtaaaataca aaattcctta gacataatag ctaaacatca
     3661 caaggatgtg tctagtcagt ttttacacct tttctacact agatgttaat ttctgcaagg
     3721 ttactttcca attatttgaa ttgccttttt aaaagttaaa atgtccagac actaagactt
     3781 acatgtgttc agcactgatc atgcaatgga atggtagcat tttggtagaa taaccaaagc
     3841 tgtttatttg attgattctt tttaatggaa gcctgttggg ctaatcacac tgcatctgac
     3901 ccagcactga ctggtacgca tccctacgct tgtgtagaaa tatctggagg atttgtgttt
     3961 agtgattgcc cttcctctcc cacttatatc tagcacttta tgacatagga aacagagaga
     4021 atgtgcagtg ttacctgggg tcattgtgca ataatgctgc taaagtcgcc gcacgtgtgg
     4081 gttagtgtga cactcaatat tcatgtaagc acatgtcctg tagacatttt aaaatataaa
     4141 gctttaactg gagtcagaga agcgagctgt tcgaacactg tatcactgta tagaaattgc
     4201 ttagtggaat tccacttttt taaaataaaa aaataaataa agggaa
//
LOCUS       NM_001437356            2008 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 4, mRNA.
ACCESSION   NM_001437356 XM_063271317
VERSION     NM_001437356.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271317.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.262635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000012.1  40090950-40091098
            150-250             JAXUCZ010000012.1  40093232-40093332
            251-420             JAXUCZ010000012.1  40093729-40093898
            421-610             JAXUCZ010000012.1  40096705-40096894
            611-730             JAXUCZ010000012.1  40098953-40099072
            731-912             JAXUCZ010000012.1  40100973-40101154
            913-1094            JAXUCZ010000012.1  40102786-40102967
            1095-1315           JAXUCZ010000012.1  40106323-40106543
            1316-1390           JAXUCZ010000012.1  40109132-40109206
            1391-1583           JAXUCZ010000012.1  40110908-40111100
            1584-1787           JAXUCZ010000012.1  40112332-40112535
            1788-2008           JAXUCZ010000012.1  40113600-40113820
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2008
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..149
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            150..250
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    245..247
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             251..1930
                     /gene="Ccdc63"
                     /note="isoform 1 is encoded by transcript variant 4;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_001424285.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR"
     misc_feature    <686..1507
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <686..1507
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            251..420
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            421..610
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            611..730
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            731..912
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1094
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1315
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1390
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1583
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1787
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..2008
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggta agttagggta cacacagcgc
       61 cccctgccgg cgatgagcac aggctggggg ctccggcaag ccaggaacca gcaactgcca
      121 ccgtaaatgc tccccaagcc caaagagcgg acattgcaga cagaggagac actgagagaa
      181 cgagaaagaa gtgggcttgc tagctttgac ctccaggacc cagtgtctaa gcagaaagga
      241 agcttagacg atgaagaaac acaggaggaa ggtctctgaa ccccttccgg aactttccga
      301 gaaggccaaa gagcagttgg ctgaggcaga gctacggaaa ctaaggcagc agttccggaa
      361 gatggtagac agccgaaagt cttccaattt ccgcaaccag cggatgatcg ccagccagta
      421 caaggagata gagaatttga aagcggagca ggcagagacc accttgcttc tgagcctcgt
      481 gaagtcgcca aagaacctag acctcaacca gaaaaatttc acggagctgc gcttcctgct
      541 gcagaccaag ggggactacg aggctctgat ctcctccatg aaggtgctgc tgggagaact
      601 ggatgacaag attgttcaga tggagagaaa gatcacaaac cagagacaga tcttcttgaa
      661 gacacaagag gccaacaatc cccggaagct gcagaaacag atccacattc tggagaccag
      721 actgaacctg gtcactgtcc actttgacac gatgttgacc tccaatgccc agctccggaa
      781 ggatattgag gatcttctct ttgagaaggc tgcctacgac catgtctacc agcagcttca
      841 gcggcgtctg cagacacaga agaagaccat gaatgtggcc atcgagcagt ctacccaggc
      901 ctatgagcag agagtggaag ccatggctcg gatggctgcc atgaaggacc gccagcaaaa
      961 agacatctct cagtacaacc tggagatccg agagctcgaa cgcctgtatg accacgagaa
     1021 caaactcaag tcctttctgc ttgtcaagct caatgaccgc acggaattcg aggaccaggc
     1081 caagaagcag gaagctgtca aaattaagaa gcatgggaaa aagaggaagg gtgagagctt
     1141 tgagagctac gaggtggccc atctccgact gctaaagctg gctgagaacg gggacctgaa
     1201 ccagctcact gaggacttcc tggccaagga ggagaagaat tttgctcgct tcacctatgt
     1261 caccgagctc aacaatgaca tggagaccat gcacaagagg acccagcgga tccaggatga
     1321 catcatcaac ctgcggtcac agcagcagtc ctcccatgag ggcacccgga acatcctgaa
     1381 acagatggag gagaaactga ggaagaccac cgaggacacg gacatttatg agaacaggta
     1441 cagggaaatg agcaagaccc tggagtacct caagaactca gtggagaagc tgtttaagaa
     1501 gatcaactgc aatgccacgg agatcctggg gaaactgggt gagactggga agatcacgga
     1561 cagcaacctt cagcagtact tcgctatcat agaaaagaag acaaatgacc tcctgcttct
     1621 ggagtctttc cggcgcctgc aggaggcaga ggggcccgat gttgatgtcc cacaaccctt
     1681 tgtcaacccc ttctgggggg gctctgccct cctcaagccc ccagagccct taagggttgt
     1741 gccgcctgtg tttggggcag actccttcag tgacaaagtt gaagaggttc ctcacagagc
     1801 tctgtcctgg gtgcagtgga ataccctctg gaccacagta gcctccggca gctggtcttg
     1861 gagaactacc ttcagaagga acgaggaaaa gaaccacagg agacactgtt ggagaagggg
     1921 gacgagataa gggtcaagaa gaaggtgata agctgaaccc cgtgggtggc tgtattccac
     1981 accgagaaaa taaatgtttt cttgccga
//
LOCUS       NM_001437329            1746 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 12 (Chst12),
            transcript variant 3, mRNA.
ACCESSION   NM_001437329 XM_039089387
VERSION     NM_001437329.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Prisco,S.Z., Prokop,J.W., Sarkis,A.B., Yeo,N.C., Hoffman,M.J.,
            Hansen,C.C., Jacob,H.J., Flister,M.J. and Lazar,J.
  TITLE     Refined mapping of a hypertension susceptibility locus on rat
            chromosome 12
  JOURNAL   Hypertension 64 (4), 883-890 (2014)
   PUBMED   25001272
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Hiraoka,N., Nakagawa,H., Ong,E., Akama,T.O., Fukuda,M.N. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of two distinct human chondroitin
            4-O-sulfotransferases that belong to the HNK-1 sulfotransferase
            gene family
  JOURNAL   J Biol Chem 275 (26), 20188-20196 (2000)
   PUBMED   10781601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039089387.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1001473.1,
                                           SRR21887622.1001468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000012.1  19242837-19242930   c
            95-1746             JAXUCZ010000012.1  19224545-19226196   c
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1746
                     /gene="Chst12"
                     /note="carbohydrate sulfotransferase 12"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
     exon            1..94
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     exon            95..1746
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Chst12"
                     /note="upstream in-frame stop codon"
     CDS             172..1431
                     /gene="Chst12"
                     /EC_number="2.8.2.5"
                     /note="carbohydrate (chondroitin 4) sulfotransferase 12"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 12"
                     /protein_id="NP_001424258.1"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
                     /translation="MTKPRLFRLWLALGSALMILLIIVYWDNVGTAHFYLHTSLSRPH
                     ILEPLPTQGLAEENVLASDVDEFLDTLLSSDAKHNDLSRRKTEQPPVLTPSKPVLSHM
                     EENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELN
                     HLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTH
                     LTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFA
                     VPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLC
                     HPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLA
                     WRQQLYKLYEADFVLFGYPKPENLLRD"
     misc_feature    664..1404
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
     misc_feature    664..1404
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
ORIGIN      
        1 agaatcagca gcctcagcaa cagcagcagc agcagcagcg gtggtgactg tagcgggcgc
       61 taggtgagaa tcgcaggctg gagcggagtg aggggtccct ctcccagcac catgtcccag
      121 cggtacacaa ggctgaagtg aagggccagg tgtggccctg cccagggcag catgaccaag
      181 ccgcggctct tccggctgtg gctggcacta gggtcggccc tcatgattct tttgatcatt
      241 gtatattggg acaacgtggg cactgcccac ttctatctgc atacgtccct gtccaggcca
      301 cacatcctag aaccccttcc cacccagggg ctggcagagg agaacgtgtt ggcttccgat
      361 gtggacgagt ttttggacac gctccttagt tctgacgcga aacacaacga cctttccagg
      421 agaaaaactg agcagccccc ggtgctcacc cccagcaagc cagtcttgag ccacatggag
      481 gagaacgtga gaggctacga ctggtccacc catgatgccc agcagaaccc agaccgggac
      541 aggcagcagg ccgagaggag gagcctgctg agggatttct gtgccaacgc cagcctggca
      601 ttccccacca aggaccgctc ttttgacgac atccccaact acgaactgaa ccacctgatt
      661 gtggacgacc gccacggggt catctactgc tacgtgccca aggtggcctg caccaactgg
      721 aagcgagtga tgatcgtgct gagcgagagc ctgctggacc ggggcagccc ctaccgagac
      781 cccctggaca tcccccggga gcacgtgcac aacaccagca cgcacctgac cttcaacaag
      841 ttctggcgcc gctacgggaa gttctcccgt cacctcatga aggtcaagct gaagaagtac
      901 accaagttcc tgttcgtgcg cgaccccttc gtgcgcctca tctcagcctt ccgcagcaag
      961 ttcgagctgg aaaacgagga gttttaccgc aagttcgcgg tgcccatgct ccggctgtac
     1021 gccaaccaca ccagcctgcc cgcctcggtg agcgaggctt tcagcgcagg cctcaaggtc
     1081 tccttcgcca acttcatcca gtacctcctg gacccacaca cggagaagct ggcgcccttc
     1141 aacgagcact ggcgacaggt gtaccgcctc tgccacccgt gccagataga ctacgacttc
     1201 gtggggaagc tggagaccct ggatgaggat gctgcccagc tcctgaggtc cctcaaggta
     1261 gactcccaac tccacttccc tcccagttac cggaacagga ccgccagcag ctgggaggaa
     1321 gactggtttg ccaacatccc cctggcctgg aggcaacagc tctataaact ctacgaggcc
     1381 gactttgttc tctttggcta ccccaagcca gaaaacctgc tcagggactg agctcccata
     1441 agccctcacg ctgccacaag aaactgagat ggtcctttga gaatgggacc ccgtggcctc
     1501 ctggttctct cctggcttcc tgtaccttcc ctggtgtaga caggcagagg atgacacaac
     1561 ccaagcacct cactctccag agtttcgcgc cccaccccca cccccaccct tttgcaatct
     1621 gggtttgttt actccacagc ctgtactcat gggacactgt gttaatactg ttttctacga
     1681 ttaatatatt tcagatatat ttaataagaa agtgggagga agctggagta aagtgtggag
     1741 cccgca
//
LOCUS       NM_001437345             897 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus stem-loop binding protein like (Slbpl),
            transcript variant 2, mRNA.
ACCESSION   NM_001437345 XM_063277048
VERSION     NM_001437345.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Thelie,A., Pascal,G., Angulo,L., Perreau,C., Papillier,P. and
            Dalbies-Tran,R.
  TITLE     An oocyte-preferential histone mRNA stem-loop-binding protein like
            is expressed in several mammalian species
  JOURNAL   Mol Reprod Dev 79 (6), 380-391 (2012)
   PUBMED   22467188
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277048.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2185532.1,
                                           SRR26360181.1792987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000018.1  26630518-26630719
            203-305             JAXUCZ010000018.1  26630832-26630934
            306-407             JAXUCZ010000018.1  26634060-26634161
            408-512             JAXUCZ010000018.1  26634269-26634373
            513-665             JAXUCZ010000018.1  26635446-26635598
            666-897             JAXUCZ010000018.1  26637463-26637694
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..897
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="stem-loop binding protein like"
                     /db_xref="GeneID:100363294"
                     /db_xref="RGD:2323347"
     exon            1..202
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..305
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="upstream in-frame stop codon"
     exon            306..407
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..678
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="isoform 2 is encoded by transcript variant 2; stem
                     loop binding protein 2"
                     /codon_start=1
                     /product="uncharacterized protein LOC100363294 isoform 2"
                     /protein_id="NP_001424274.1"
                     /db_xref="GeneID:100363294"
                     /db_xref="RGD:2323347"
                     /translation="MSLSSRMEMVSVGVTTEPCHARWEVETDEVVLRRRQKQIDYGKC
                     TPGYQSFLQQVPRAQRQPGFHPQTPNKNRRYSRRSWDAQIRQWRRALHTWDPPSQPLH
                     DRQAEGLHT"
     misc_feature    421..630
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="Histone RNA hairpin-binding protein RNA-binding
                     domain; Region: SLBP_RNA_bind; pfam15247"
                     /db_xref="CDD:464587"
     misc_feature    421..630
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="Histone RNA hairpin-binding protein RNA-binding
                     domain; Region: SLBP_RNA_bind; pfam15247"
                     /db_xref="CDD:464587"
     exon            408..512
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..665
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..897
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actacatttt tcctgcactc aattgtctcc gccccagcaa ccccgggaga tttaaattga
       61 gtccccttaa tattgccaat cttgaggaac tgttttggag tcaagtgttc gcttctcctt
      121 gcttctttct cttgggtttt gttacctttc ggctggaaat ggagctcctg ccaccggtgt
      181 gacagtggtt ggggcatgac aggagggttt catgcctata atcccagcac ttagaagact
      241 gtaatcgaag agtcgccgtg agtttgagga catcccgcag tgagtccaga tcgccgtggg
      301 ctagactgca gaagctgctt ccccagaaag aaggtgtgtg aaatgtcttt gtcctctagg
      361 atggagatgg taagtgtggg agtcaccaca gagccttgtc atgccaggtg ggaagttgag
      421 acagatgaag tggtcctgag gcggcggcag aagcagatag actatggcaa gtgcacacct
      481 gggtaccaga gctttctgca gcaggtcccc agggcacagc gacagccggg ttttcaccct
      541 caaacaccaa acaaaaacag gaggtacagc cgcagatcct gggatgccca gatcaggcag
      601 tggagaagag ccctgcatac ctgggacccc ccaagccagc ctctccatga cagacaggct
      661 gaaggtttgc atacttgaag gttcctgctt cctgccctcc ccagctcaaa gatgaacttc
      721 tccatcacta agtctgctgc tgtttaccta tcccagacaa ggggggattc aaagcattca
      781 cagcgaacac tttattttta gggatttgct gctacaactg tataataatg aaatgactgg
      841 aattactttt tttttaatta ccactttaac cgattaaaaa agaaatctaa aactcca
//
LOCUS       NM_001437249            1115 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus LSM10, U7 small nuclear RNA associated (Lsm10),
            transcript variant 4, mRNA.
ACCESSION   NM_001437249 XM_017593541
VERSION     NM_001437249.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1115)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   2  (bases 1 to 1115)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   3  (bases 1 to 1115)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
REFERENCE   4  (bases 1 to 1115)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017593541.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.60054.1,
                                           SRR26360176.2439179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000005.1  143657858-143658211
            355-1115            JAXUCZ010000005.1  143659631-143660391
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1115
                     /gene="Lsm10"
                     /note="LSM10, U7 small nuclear RNA associated"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
     exon            1..354
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     exon            355..1115
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    355..357
                     /gene="Lsm10"
                     /note="upstream in-frame stop codon"
     CDS             379..747
                     /gene="Lsm10"
                     /note="U7 snRNP-specific Sm-like protein LSM10"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm10"
                     /protein_id="NP_001424178.1"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
                     /translation="MALSHSVKERTISENSLIILLQGLQGQITTVDLRDESVARGRID
                     NVDAFMNIRLANVTYTDRWGHQVELDDLFVTGRNVRYVHIPDGVNITATIEQQLQIIH
                     RVRNFGGKGQGRREFPSKRP"
     misc_feature    400..633
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    400..633
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    order(463..483,487..525,529..543)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(463..483,487..525,529..543)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(517..519,523..525,601..603)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    order(517..519,523..525,601..603)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    589..624
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    589..624
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
ORIGIN      
        1 gaatcagatt taggccatct gcaataatat acagtatttt tttttaaaga tttatttcat
       61 cggacttcat tatggatggt tgtgagccac catgtggttg ctgggaattg aactcaggaa
      121 ctccggaaga gcagtcagtg ctcttaacgc tgagccatct ctccagaccg tgtgtggtct
      181 taattgctaa agtttagcac tctctccata gccctgtgtt ttcctctttg agacagggtt
      241 agctatcctt gctctcctgg tctctccaac tcacagagcg cctctgtctc tggagtcgct
      301 ggaattaagg gagtttgcca ccacgtccgg ccacattcgc tgaattttaa tcagtgagca
      361 gccaaccaat gtggaaaaat ggcactgagc cactctgtga aggagcgaac catctctgag
      421 aacagcctga tcatcctgtt gcaaggcctc cagggacaaa taaccactgt ggaccttcga
      481 gatgagagtg tggcccgagg acgcatcgac aacgttgatg ctttcatgaa catccgtctg
      541 gccaatgtca cctacaccga ccgctggggg catcaggttg agttggatga ccttttcgtg
      601 acaggtcgta atgtccgata tgtccatatc ccagacggtg tgaacatcac tgccacaatc
      661 gagcagcagc tacagatcat ccaccgtgtg cgcaactttg gtggcaaggg tcaaggtcgt
      721 cgagagttcc cctccaaaag gccatgagac tgtgtcctca ttcaaattcc agcaccacct
      781 cagggacctc cagtgttctg agccaactcc cgtccatcct tccccaccaa tgacctggtg
      841 tcttatagac acatcacagc tgcctttcat agggttccac ttttcagaca caccttggga
      901 cccagaattc cttctgctgg tggccttggg gtaggtgaca atccctcttt ttgatcattt
      961 gtatctggaa tctccattca ctgattgacc ccatccatca aggagttgtt aactctgcca
     1021 gtgaggatta cttgagagtg tttggagtga atcacctcta acatcccatt tctcttgtca
     1081 tttgtttctt ttctcataaa accaaactcc tggga
//
LOCUS       NM_001437358            1900 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 7, mRNA.
ACCESSION   NM_001437358
VERSION     NM_001437358.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85238.1,
                                           SRR26360181.1826346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000012.1  40085187-40085357
            172-341             JAXUCZ010000012.1  40093729-40093898
            342-531             JAXUCZ010000012.1  40096705-40096894
            532-651             JAXUCZ010000012.1  40098953-40099072
            652-833             JAXUCZ010000012.1  40100973-40101154
            834-1015            JAXUCZ010000012.1  40102786-40102967
            1016-1236           JAXUCZ010000012.1  40106323-40106543
            1237-1311           JAXUCZ010000012.1  40109132-40109206
            1312-1504           JAXUCZ010000012.1  40110908-40111100
            1505-1708           JAXUCZ010000012.1  40112332-40112535
            1709-1900           JAXUCZ010000012.1  40113629-40113820
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1900
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..171
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     misc_feature    118..120
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDQLLISMDSTVSQPLQM"
     misc_feature    139..141
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MDSTVSQPLQM"
     misc_feature    169..171
                     /gene="Ccdc63"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     M"
     CDS             172..1848
                     /gene="Ccdc63"
                     /note="isoform 2 is encoded by transcript variant 7;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     2"
                     /protein_id="NP_001424287.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVEYPLDHSSLRQLVLENYLQKERGKEPQETLLEKGDEIRVKKKVIS"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <607..1428
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            172..341
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            342..531
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            532..651
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            652..833
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1015
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1236
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1311
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1504
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1708
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1900
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttttgtt ttctctggtt gacgtgtggg ccatgatcct ccacatagtt ccaagaaggc
       61 tgccatagct ccagacatca aagcctcgta caagcagaat cccaacagga aaggaagatg
      121 gaccagttgc tgatttccat ggactcaacc gtatcacagc cgctgcaaat gatgaagaaa
      181 cacaggagga aggtctctga accccttccg gaactttccg agaaggccaa agagcagttg
      241 gctgaggcag agctacggaa actaaggcag cagttccgga agatggtaga cagccgaaag
      301 tcttccaatt tccgcaacca gcggatgatc gccagccagt acaaggagat agagaatttg
      361 aaagcggagc aggcagagac caccttgctt ctgagcctcg tgaagtcgcc aaagaaccta
      421 gacctcaacc agaaaaattt cacggagctg cgcttcctgc tgcagaccaa gggggactac
      481 gaggctctga tctcctccat gaaggtgctg ctgggagaac tggatgacaa gattgttcag
      541 atggagagaa agatcacaaa ccagagacag atcttcttga agacacaaga ggccaacaat
      601 ccccggaagc tgcagaaaca gatccacatt ctggagacca gactgaacct ggtcactgtc
      661 cactttgaca cgatgttgac ctccaatgcc cagctccgga aggatattga ggatcttctc
      721 tttgagaagg ctgcctacga ccatgtctac cagcagcttc agcggcgtct gcagacacag
      781 aagaagacca tgaatgtggc catcgagcag tctacccagg cctatgagca gagagtggaa
      841 gccatggctc ggatggctgc catgaaggac cgccagcaaa aagacatctc tcagtacaac
      901 ctggagatcc gagagctcga acgcctgtat gaccacgaga acaaactcaa gtcctttctg
      961 cttgtcaagc tcaatgaccg cacggaattc gaggaccagg ccaagaagca ggaagctgtc
     1021 aaaattaaga agcatgggaa aaagaggaag ggtgagagct ttgagagcta cgaggtggcc
     1081 catctccgac tgctaaagct ggctgagaac ggggacctga accagctcac tgaggacttc
     1141 ctggccaagg aggagaagaa ttttgctcgc ttcacctatg tcaccgagct caacaatgac
     1201 atggagacca tgcacaagag gacccagcgg atccaggatg acatcatcaa cctgcggtca
     1261 cagcagcagt cctcccatga gggcacccgg aacatcctga aacagatgga ggagaaactg
     1321 aggaagacca ccgaggacac ggacatttat gagaacaggt acagggaaat gagcaagacc
     1381 ctggagtacc tcaagaactc agtggagaag ctgtttaaga agatcaactg caatgccacg
     1441 gagatcctgg ggaaactggg tgagactggg aagatcacgg acagcaacct tcagcagtac
     1501 ttcgctatca tagaaaagaa gacaaatgac ctcctgcttc tggagtcttt ccggcgcctg
     1561 caggaggcag aggggcccga tgttgatgtc ccacaaccct ttgtcaaccc cttctggggg
     1621 ggctctgccc tcctcaagcc cccagagccc ttaagggttg tgccgcctgt gtttggggca
     1681 gactccttca gtgacaaagt tgaagaggtg gaataccctc tggaccacag tagcctccgg
     1741 cagctggtct tggagaacta ccttcagaag gaacgaggaa aagaaccaca ggagacactg
     1801 ttggagaagg gggacgagat aagggtcaag aagaaggtga taagctgaac cccgtgggtg
     1861 gctgtattcc acaccgagaa aataaatgtt ttcttgccga
//
LOCUS       NM_001437308            5245 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus KIAA1328 homolog (Kiaa1328), transcript variant
            2, mRNA.
ACCESSION   NM_001437308 XM_017601012
VERSION     NM_001437308.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5245)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017601012.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.76441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000018.1  16763254-16763301
            49-191              JAXUCZ010000018.1  16771469-16771611
            192-286             JAXUCZ010000018.1  16776653-16776747
            287-402             JAXUCZ010000018.1  16794966-16795081
            403-530             JAXUCZ010000018.1  16865059-16865186
            531-1204            JAXUCZ010000018.1  16920208-16920881
            1205-1288           JAXUCZ010000018.1  16927043-16927126
            1289-1470           JAXUCZ010000018.1  16983935-16984116
            1471-1579           JAXUCZ010000018.1  16996889-16996997
            1580-5245           JAXUCZ010000018.1  17047419-17051084
FEATURES             Location/Qualifiers
     source          1..5245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5245
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="KIAA1328 homolog"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
     exon            1..48
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1784
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="protein hinderin isoform 2"
                     /protein_id="NP_001424237.1"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
                     /translation="MVTGISTERNTRSRLKLINPKVDAKVKVPKVTDIPASMESLKGA
                     GDSVAEQSFCKRGLKSASLKDLCVEDKRRIANLIKELARVSEEKEVTEERLKTEQESF
                     EKKIRQLEEQNELIIKEREALQLQYRECQELLSLYQKYLSEQQEKLTMSLSELGAARA
                     QEQQITKKKITHQSSLVNLDGSYLSVAKPQTCQTRARPKSENQDSASESHTALRNNSL
                     KPVTLHHPKQDLERMSTETRTCTYESPGRRLINAAPVEEALPEELKIKDYPNLLPTPS
                     SQYCGHKYSESEAYVHENYHPTNMASQCCKTHPESCSHCRMSWASLMHDGVTLQPRET
                     DIEKQLSEDRRQQLMLQKMELEIEKERLQQLLAQQETKLLLKQQQLHQSRLDYNWLRT
                     QAVFRSRELVADKDFPKPGSDSGPSLLKPKCDGWLRGTSSSFRKCPDSPNSAQNQKEK
                     KTVEFQSHVENGIQWTCQQNDTCRLQRETATGVRKDASTSPMSTQSPKHPLTPASSSS
                     KHKTSRYETSLLDLVQSLSPNSAPKCQPHSSRAAGTWSALRPTPKTSTWKKVGTHKSP
                     EDLEENQILEDIFFI"
     misc_feature    231..1202
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     misc_feature    231..1202
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     exon            49..191
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            192..286
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            287..402
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            403..530
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1204
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1288
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1470
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1579
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..5245
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgggatgg agataattcc aggtggagga aactaaaaat ggttacagga atctccacag
       61 aaagaaatac aagatcaagg ctcaagttga taaatccaaa agttgatgct aaagttaagg
      121 ttcccaaggt gactgatatt cctgcctcca tggagtcttt aaaaggtgca ggagattcag
      181 tagctgaaca gagtttctgc aagagaggac tgaagagtgc gtcattgaaa gatttatgtg
      241 ttgaggacaa aaggcgcatt gccaatttaa ttaaagaact ggccagagta agtgaagaaa
      301 aggaggtgac agaggagcga ctgaaaactg agcaggagtc ctttgagaag aagatccggc
      361 agttggagga acagaatgaa ctgatcatca aagaaaggga agctcttcag ctacagtata
      421 gagaatgtca agaacttcta agtctctacc agaagtacct gtcagagcag caagagaagc
      481 ttaccatgtc gctctcagag cttggagctg ctagagcaca ggaacagcag ataaccaaga
      541 agaaaatcac tcaccagtct tcattggtga acctggatgg ttcctatctg agtgtagcca
      601 aaccgcaaac ctgccagacc agggccaggc ctaagtcaga aaaccaggac tcagcttcag
      661 aatcccacac agcattaagg aataattctt tgaaaccagt aacacttcat catcccaaac
      721 aggatttaga gaggatgtca acagaaacca gaacgtgtac ttatgaatct ccagggagga
      781 gactaataaa tgcagcccca gtagaggaag ctctcccaga agagttgaag ataaaggact
      841 atccaaacct tctgcctact ccatctagtc agtactgtgg tcataaatac tctgaaagtg
      901 aagcttatgt tcatgagaac tatcatccta cgaacatggc ctctcagtgt tgtaagacac
      961 atccagaatc atgcagtcat tgtaggatgt cctgggcatc tctcatgcat gatggagtga
     1021 cactgcaacc cagagaaacc gacatcgaaa aacaactctc agaagatcga aggcagcagc
     1081 tgatgcttca gaaaatggaa ctggaaattg aaaaggaacg ccttcagcaa ctcctggccc
     1141 aacaagagac aaagcttctc cttaaacagc agcagctgca ccaatcccga ctagattaca
     1201 attggttaag aactcaagct gtgtttagat ctcgagaact ggttgctgat aaagactttc
     1261 ctaaacctgg aagtgactct ggaccaagtt tattgaagcc gaaatgtgat ggatggctgc
     1321 gtggaacctc atcgtccttc agaaagtgcc cagactctcc aaacagtgcg caaaaccaga
     1381 aggagaagaa aactgttgag tttcagtcac acgtggagaa tggcattcaa tggacatgtc
     1441 aacagaatga cacatgcaga ctccagagag agacagcaac tggagttaga aaagatgctt
     1501 ccacatctcc tatgtcaaca caaagcccta aacaccccct gacaccagcc tcatcgtcat
     1561 ccaagcacaa aacctcaagg tatgagacat ctctgttgga cttggttcag tctctgagcc
     1621 caaattctgc tcctaaatgt cagccccatt cctccagagc agcagggaca tggagtgctc
     1681 tccgacctac ccctaagaca tctacctgga agaaagtggg gacacataag agccctgagg
     1741 acctggagga gaatcagatt ctggaagaca tatttttcat atgactctga agcacatgct
     1801 acagaatttc cacaggaaat atttgagttt ctttccatat tgatgtagga tgttaaactg
     1861 aaaagaagcc gtgtctctcc tttcgtggag acctcttgct ggcatccttt tatagtattg
     1921 aatatagaaa gcattcttat aaatcagggt ggtttttgtc agaccagtta gcagaaacag
     1981 actaaagggg gtcacttaga ggtaggatct tttctatacc aaacagaaat tagaaattgt
     2041 ggatactgcc tgcatagtaa aacccatgaa tgtctagtgt cattttaaga gtgttttcaa
     2101 tttactactg caaaaagttg actctttaca gatggaaaac gttcccattg acagacccct
     2161 taaatatgaa agtagccact tcagaaaggc tcttctctcc tcaccaatgc taagtgtggc
     2221 gcttcattcc gacgttgaag ttggtgactc taatatcatc ttacatggga ccaatacttg
     2281 tgggtcatag tggtcaaccg agtcattgcc accccttaaa ccaaaaggct gaatgactta
     2341 gagggaagtt tgcaaccaga cagtggcatt agaccacatg agggcatggc cgcctgggga
     2401 aatttaccag tgtccaggca gccacctctc cagtgttcca tgatgggtgt ttcttgtcga
     2461 cttcagtgtt gtaaacttta cctgtggttg tgtctgagga agatagcact agaggaagag
     2521 tggtgtcgag tggctgcagg ctggcaggtt ccttctgccc cacctcacac cataggacga
     2581 gtatcctcct ctgagcaccg tggatgcaga gtctgagaac gctctgctga ttacccttct
     2641 tggcccagat ctagatcttt tctcctcagg ctgagctcag tgctgttggt tctactcagg
     2701 ctccctccca agctcatact cttcctctga agcagctgca agggcaagac taattaccct
     2761 ttggaaattt aaagttcatt gaaaattcca attttctttt caaattcagc ctgagagtaa
     2821 ctagaacaga cttgttctac ttcaaaacac ctttaggata tgcctttgga ggggcagaaa
     2881 tagccatatt ctcagttggg tttccagaaa catcttttct ctatcttgtg tcaaagacag
     2941 cttaactata cctatttctt tacacctgct ataaccatag tcaccgttct gagcatcagt
     3001 agtcttacta ctcctgtata tctccagaag gaaaagaaag agaatctgat ctccttaaga
     3061 agcttattta caggtagaag agttgtaaac ggcctaaaaa tgaaagcttt tgtgcagtga
     3121 catgccagtg aatagaattt aattgcttct tcaccagcat gggaagtttg gaagagaaaa
     3181 aaggggggtt ttcagtcagt acacttttta tacttcacag atctgccatg cgttaccttc
     3241 ttctcatgca tatacataca tacatacaca cacacacaca cacacacgga tatatatata
     3301 tatatatata tatatatata tatatatata tatatcctag tgactttgtt attaaccaaa
     3361 tagtatattg tggcccatcc cacagaagaa tgggaagaaa gtaggagcca tgtgcctccc
     3421 tggataatgc tctcttcggt ggttggttgg gacttgcttg gccagctcct agatgtttcc
     3481 tccaagcaaa actgcactca atgataaaaa tttagtttaa caagattcac caaggtcacc
     3541 agatagtaag gagcaattca aacccagagg tgaagatggg gggaagggga gtcattgttc
     3601 ttttctttac ttctctttcc tattttgagt aaatatcaaa accatcaaga ccattttcta
     3661 cagtccagtt attatttatc agacacatgg attggtaagg agaggagagc agtgggaaga
     3721 agggattaaa ggaaacaggc ctacatccct ttgcagcctt ggtacaattc cttattgcat
     3781 gcagttctct cataaaggag aagaggacca gaagagagaa atggagatgg tgggctctgg
     3841 gacccttcca ctgctccttc ctcagtgcct tatctgcagt gtttaatgtt tttcttccaa
     3901 atttaagatt tctaactctc atacttggaa atacaaagaa ctccccaggg cttacaggtc
     3961 aaggggcaca ggccctagag aggcacatca gggctctctg tctccagccc catgtccctt
     4021 tgctgcatca gccgcctcca ttaccctctt ctttgctccc cattgcagct caccactgtt
     4081 agacacatcc caatggcaca cttctcttcc caggtccttc tgggtgaata acttaagact
     4141 aagtttttac cactttgtga aattttcctt atgttcctgg cactgtgtac tgttgactcc
     4201 agtaagatgt gcagatatgt ccaacccata agccataagc tgtgacgtat ggtcaaggat
     4261 agctgtgaat gtggcccaac acaaaattgt aaacgtaaga cattttgagt agtgtggtta
     4321 tttttgtttt tcacttttgt gtgtgtgact tgattgtgca gctctcaaac atgaacattg
     4381 tatataataa atcatgtcat catgttgctg tgtcaaaggc tggccatgcg gcaagtccaa
     4441 gcctctgtgg tggccctcct cgtcatgcca cattgtactg ggtactgttt gcctttcttg
     4501 ttagagttcc aggtgtccag actaacatat gctatgtcgg agaagccaag ttcaccattt
     4561 gtaacataca gacatgcagg tgagttattg ataccttcag ataatgataa ttctacctgc
     4621 agttttaggc cttatctgct gacctagccc taaaagccta gaccagagaa aagctagaat
     4681 gagaaggtca aagttcccaa gaatgtgaag ctgacagttg gggggcactg agacccatct
     4741 ccttagaaca tggggcaacc aacagaccca aaggcaggga gcagagtcag tgttagaaca
     4801 gtacagagct ggttgaccag aacagtttca ttccagagct gacacccctc tgccctctgt
     4861 ggtctgacac ctgattggct catgccaagc aagcactagc acaaacattg cccacagtga
     4921 ctcccaccca gaagctccct ctttctcttc cccagatgct gccccacact ctcctccaca
     4981 ctctttccag ctctaggtcc taaggtggcc aggaggctgc tgagatgagg gagaccatgc
     5041 tgtatcccag ggaaatgggg tgagccctta gttttcaaac ctcctctgag agattttaac
     5101 ttgttggatt tatgtagcat tggaaaatga taaactgtat gaattttctg tattttccat
     5161 ggacagttat ttatggaggg gcgtttttaa ctcaagtgct agaaatgtta aatcatcata
     5221 ataaattcat gctattcaga ctttc
//
LOCUS       NM_001437277            5070 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 5, mRNA.
ACCESSION   NM_001437277 XM_063288134
VERSION     NM_001437277.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5070)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 5070)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 5070)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5070)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5070)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 5070)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 5070)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 5070)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 5070)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 5070)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063288134.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.30338.1,
                                           SRR21887620.876226.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000005.1  165405713-165405877 c
            166-284             JAXUCZ010000005.1  165403843-165403961 c
            285-457             JAXUCZ010000005.1  165392825-165392997 c
            458-686             JAXUCZ010000005.1  165389591-165389819 c
            687-916             JAXUCZ010000005.1  165389275-165389504 c
            917-1096            JAXUCZ010000005.1  165388373-165388552 c
            1097-1246           JAXUCZ010000005.1  165388101-165388250 c
            1247-1336           JAXUCZ010000005.1  165387693-165387782 c
            1337-1558           JAXUCZ010000005.1  165386476-165386697 c
            1559-1655           JAXUCZ010000005.1  165385787-165385883 c
            1656-1786           JAXUCZ010000005.1  165385559-165385689 c
            1787-1837           JAXUCZ010000005.1  165384765-165384815 c
            1838-2005           JAXUCZ010000005.1  165384521-165384688 c
            2006-2136           JAXUCZ010000005.1  165384309-165384439 c
            2137-2280           JAXUCZ010000005.1  165383996-165384139 c
            2281-2380           JAXUCZ010000005.1  165383697-165383796 c
            2381-2559           JAXUCZ010000005.1  165383289-165383467 c
            2560-2672           JAXUCZ010000005.1  165383088-165383200 c
            2673-2751           JAXUCZ010000005.1  165382877-165382955 c
            2752-2919           JAXUCZ010000005.1  165382365-165382532 c
            2920-3043           JAXUCZ010000005.1  165381666-165381789 c
            3044-3189           JAXUCZ010000005.1  165381296-165381441 c
            3190-3322           JAXUCZ010000005.1  165380825-165380957 c
            3323-5070           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..5070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5070
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..165
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            166..284
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            285..457
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    305..307
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             317..3460
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform b is encoded by transcript variant 5;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform b"
                     /protein_id="NP_001424206.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQ
                     LQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQLSQ
                     MLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKY
                     ESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHM
                     KVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDP
                     STLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQ
                     LMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKD
                     ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHID
                     FGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRR
                     HGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW
                     KTKVNWLAHNVSKDNRQ"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    416..637
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    860..1159
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    860..1159
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1256..1759
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1256..1759
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1826..2377
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1826..2377
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2351..3451
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2351..3451
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2579..2581,2585..2593,2597..2599,2603..2605,
                     2654..2656,2660..2662,2669..2671,2762..2764,2798..2809,
                     2822..2824,2831..2833,3017..3019,3023..3025,3053..3058)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2579..2581,2585..2593,2597..2599,2603..2605,
                     2654..2656,2660..2662,2669..2671,2762..2764,2798..2809,
                     2822..2824,2831..2833,3017..3019,3023..3025,3053..3058)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2783..2788,3089..3094,3098..3100,3104..3106,
                     3302..3304,3311..3313)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2783..2788,3089..3094,3098..3100,3104..3106,
                     3302..3304,3311..3313)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2924..2926
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2924..2926
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2993..3019
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2993..3019
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    3056..3130
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    3056..3130
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            458..686
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            687..916
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1096
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1246
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1336
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1558
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1655
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1786
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1837
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2005
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2136
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2280
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2380
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2559
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2672
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2751
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2919
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3043
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3189
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3322
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..5070
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcactcac cgccacctcg agcggcgggg cctgccctca ggccctgccg gctgcactcc
       61 gccgcccgga ggctggcgcc ctccggtcac ttcgggaccc tcccgccgtg tcccctgggt
      121 aactgtctcc agggagacgg agcccgcccc tgccaccaac accggacaca taaggagctg
      181 agagccaggc agaagtggga tgaagctccc tgatggcaaa gcacctgtaa tctcccaggc
      241 acaggggcct tggctggtgg tccttctcgg cccatcccaa acaggagaac aggcctcaga
      301 gaagtaacac agcaggatgc cccctggggt agactgcccc atggagttct ggaccaaaga
      361 ggagagccag agcgtggccg ttgacttctt gctgcccaca ggagtctact tgaacttccc
      421 tgtgtcccgc aatgccaacc tcagcaccat caagcaggtg ctgtggcatc gtgcacagta
      481 tgagccgttc ttccacatgc tcagtgaccc cgaggcttat gtgttcacct gtgtgaacca
      541 gacagcggag cagcaggagt tggaggatga gcagcggagg ctgtgtgaca tccagccctt
      601 cctgcccgtg ctgcgcctgg tggcccgaga gggggaccgc gtgaagaagc tcatcaactc
      661 acagatcagc ctcctcatcg gcaaaggtct ccatgagttt gattccctgc gggacccgga
      721 agtaaacgac ttccgcacta agatgcgcca gttttgcgaa gaggccgcgg ctcaccgcca
      781 gcagctgggc tgggtggaat ggctgcagta tagcttcccc ctgcagctgg agccctcagc
      841 cagaggttgg cgggctggct tattgcatgt cagcaaccga cccctgctgg tcaatgtgaa
      901 gttcgagggc agtgaggaga gcttcacctt ccaggtatcc accaaggaca tgcccctcgc
      961 actgatggcc tgtgccctcc gaaaaaaggc caccgtgttc cggcagcctc tggtggagag
     1021 gcctgaggag tatgccctgc aggtgaacgg gaggcacgag tacctctacg gcagctaccc
     1081 cctctgccac tttcagtaca tctgtagctg cctgcacagc ggactgactc cccatctgac
     1141 catggtccac tcctcctcca tcctcgccat gagggatgag cagagcaacc ctgcccccca
     1201 ggtgcagaag ccacgagtca aacctccccc gatccctgcc aagaagccct cctctgtgtc
     1261 cctgtggtcc ctggaacagc cattctgcat tgagctgatt gagggccgca aggtgaatgc
     1321 ggatgaaagg atgaagctgg ttgtgcaggc cgggctcttc cacggcaatg agatgctgtg
     1381 caagactgtg tcgagctcag aggtgaatgt gtgctcagag cccgtgtgga agcagcgact
     1441 agaattcgac atcagcatct gtgacctccc ccgaatggcc cggctctgct ttgcactcta
     1501 tgctgtcgtg gagaaggcta agaaggcgcg ctccacaaag aagaagtcca agaaggcgga
     1561 ctgtcccatc gcttgggcca acctcatgct attcgactac aaagatcagc tcaagacggg
     1621 cgaacggtgc ctctacatgt ggccctctgt cccagatgag aaaggggaac tgatgaatcc
     1681 tgcgggtaca gtacgtggta accccaacac agagagtgcc gctgccctgg tcatctacct
     1741 acctgaggtg gctccccacc ctgtgtactt ccctgctctg gagaagatcc tggagctggg
     1801 gcgtcacggg gagcgtgggc gcatcacaga ggaggagcag ctgcagctgc gggagatcct
     1861 ggagcggcgg ggatctgggg aactgtacga acatgagaag gacctggtgt ggaagatgcg
     1921 tcacgaagtc caggagcatt tcccagaggc gctggcccgc ctgctactgg tcaccaagtg
     1981 gaataaacat gaggatgtgg cccagctgtc ccagatgctc tatttgctgt gctcctggcc
     2041 cgagcttcct gtgctgagcg ccctggagct tctggacttt agttttcctg actgctacgt
     2101 gggttccttc gccatcaagt ccctacggaa gctgacggat gacgagcttt tccagtacct
     2161 tctgcagctg gtacaagtac tcaaatatga gtcctacctg gactgcgagt tgaccaaatt
     2221 cttgttgggc cgagccctgg ctaaccgcaa gatcgggcac ttcctgttct ggcacctccg
     2281 ctctgagatg catgtaccgt ccgtggccct gcgttttggc ctcatcatgg aagcctactg
     2341 cagaggcagc acccaccaca tgaaggtgct gatgaagcag ggggaggcac tgagcaagct
     2401 taaggccctg aatgactttg tgaaggcgag ctcgcagaag accaccaagc cccagaccaa
     2461 ggagatgatg catatgtgta tgcgccagga gacttacatg gaggcgctgt cccacctgca
     2521 gtctcccctc gaccccagca ccctgctgga ggaagtctgt gtggagcagt gcaccttcat
     2581 ggactccaaa atgaagccat tgtggatcat gtacagcagc gagaaggcag gcggtgccgg
     2641 cagcgtgggc atcatcttta agaacgggga tgacctccgc caggacatgc tgactctgca
     2701 gatgatccag ctcatggact tcctatggaa gcaggagggc ctggacctga ggatgacccc
     2761 ctatggctgc ctccccaccg gagatcgcac aggcctcatt gaggtggtcc tccactcgga
     2821 caccatcgcc aacatccagc tgaataaaag caacatggca gccacggctg cgttcaacaa
     2881 ggacgctctg ctcaactggc tcaagtctaa gaaccctggg gaggctctgg atcgggccat
     2941 tgaggaattc accctctcct gtgctggcta ctgtgtggcc acatatgtgc tgggcatcgg
     3001 tgaccggcac agcgataaca tcatgatcag agagagtggg cagcttttcc acattgactt
     3061 tggccacttt ctggggaact tcaagaccaa gttcgggatc aaccgggagc gtgtcccctt
     3121 cattctcacc tacgactttg tccacgtgat ccagcagggg aagactaaca acagtgagaa
     3181 atttgaaagg ttccgaggct actgtgaacg agcctacacc atcctgcggc gtcacgggct
     3241 gcttttcctt catctcttcg ccctcatgcg cgcagcaggt ctgcctgagc ttagctgctc
     3301 caaagacatc cagtatctca aggactctct ggcactaggg aagacggagg aagaagcact
     3361 aaagcacttc cgggtgaagt tcaatgaagc tctccgggag agctggaaaa ccaaagtcaa
     3421 ctggctggca cacaatgtgt ccaaggataa caggcagtaa gaggcgcccc cctgggcgtc
     3481 acattcccct gggcgtcaca tggcagttcc ctggttccct ccgggctctc agccatagag
     3541 gtaaactgtc agtcctggag accaggcatg ctcagtggtc atcaaagggg ccccagacct
     3601 gaactgtccc tcacagagaa gaaccacaca actgcttctt gtttacactg gttatttatt
     3661 tatgactcga aatgtttaag gaacagaata gccataaatg gaagtgcatt tttgtgcagg
     3721 ggaggggtgc tgtcctcgtg accccccctc cctcagcact gtaaacagca ccttgaggat
     3781 cgtaccccta gtcttccaac ctgtgggtct tggcccccca aaggcagttt tgggggccac
     3841 cttcccaggc tcccagccgg ctgcctagaa caagcctggc agtcacctgg tgcctcccac
     3901 gcagacagga cacctcaatc ctcagctcag ctcacctccg ccaccttcat gtggcccacc
     3961 ctcggcgacc tccatctacc aagcctccgg cagctcctga ggaagccagg agcttccctc
     4021 tagactcagg cacacttgct ctgcactgct gaagtgacaa cctcttgggt acggaaacac
     4081 cctcaccttt tatttgcggg taagaacatg attatgtaaa ctctgtatag aatagccggg
     4141 gtaaaggacc tggcttccac tacagatagc tgtgttctgg gcctcaaaac actagagatt
     4201 ggtgcccgat ttagtgcggt gtggtcgtga atccagacaa agggcaagcc tgaacggagt
     4261 cctcttcgca atttgtgtga gaaccgcaca caaaggcagc tttctggaag gacaggactg
     4321 atgtctccca gagctgccat tctcagaagg cagctggggt cccgggttct gaagtgtgcg
     4381 cgaggaggag gaccaagttt agtagtctgg gcgactggag catctccaga aatgcagggt
     4441 ctccaccccc tcccaggtat ccaaacctac tttgggctgt agagccagtc acctggcttt
     4501 ttagagagcc cagctcagtg gtgcacatgc ataaaacgtg ccatcccgag cccaccgtga
     4561 tgcatcagct gccgcctcag gacctggctc tcccggtaac atcctgagac ttgcagaacc
     4621 atcaccgccg tcttgctggc agcccagaac atggctgctc aaggaagcca ggtgtccgct
     4681 ctttcacgat gatgaactga gggtccagca gtggttggtg cctccagggc acttgctgaa
     4741 cccttagtct gccccaactc tgaaatagga agtgtgcgtg cgtgtgcgtg cgtgtgcgcg
     4801 tgtgtgccgt gttatttatt gaaaagagtc taggtgctcc ctggtgtggc tgcagattct
     4861 gcagaggctc agcctttctg ggttgggtat gtggtctgtg tacctggctg gaaaagtatt
     4921 ttctattttt tttttttaaa agttgttcta cgtttctgta ggggggaagg tagatttcct
     4981 ctcactgatg tgggctgaga tcagtctgtg caaccctgac acgtccggta aagacaggtg
     5041 aaaagaaata aaaatctttt tatgttctta
//
LOCUS       NM_001437342            4505 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus centrosomal protein 120 (Cep120), transcript
            variant 3, mRNA.
ACCESSION   NM_001437342
VERSION     NM_001437342.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4505)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 4505)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4505)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 4505)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   5  (bases 1 to 4505)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77385.1,
                                           SRR26360181.2462081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000018.1  49388146-49388277   c
            133-198             JAXUCZ010000018.1  49387941-49388006   c
            199-355             JAXUCZ010000018.1  49383840-49383996   c
            356-497             JAXUCZ010000018.1  49379306-49379447   c
            498-646             JAXUCZ010000018.1  49375066-49375214   c
            647-844             JAXUCZ010000018.1  49373255-49373452   c
            845-1072            JAXUCZ010000018.1  49370600-49370827   c
            1073-1289           JAXUCZ010000018.1  49369293-49369509   c
            1290-1467           JAXUCZ010000018.1  49367897-49368074   c
            1468-1617           JAXUCZ010000018.1  49365316-49365465   c
            1618-1800           JAXUCZ010000018.1  49364545-49364727   c
            1801-1897           JAXUCZ010000018.1  49361228-49361324   c
            1898-2056           JAXUCZ010000018.1  49360986-49361144   c
            2057-2146           JAXUCZ010000018.1  49358919-49359008   c
            2147-2239           JAXUCZ010000018.1  49354506-49354598   c
            2240-2401           JAXUCZ010000018.1  49352257-49352418   c
            2402-2524           JAXUCZ010000018.1  49348629-49348751   c
            2525-2623           JAXUCZ010000018.1  49344147-49344245   c
            2624-2769           JAXUCZ010000018.1  49331773-49331918   c
            2770-4505           JAXUCZ010000018.1  49326266-49328001   c
FEATURES             Location/Qualifiers
     source          1..4505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4505
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
     exon            1..132
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            133..198
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            199..355
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="upstream in-frame stop codon"
     exon            356..497
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            498..646
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            647..844
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     CDS             662..3004
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="isoform 2 is encoded by transcript variant 3;
                     centrosomal protein 120kDa; coiled-coil domain containing
                     100; centrosomal protein of 120 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 2"
                     /protein_id="NP_001424271.1"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
                     /translation="MKLPERQPEFFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIR
                     SSVEVLRVYLALHSKLQIHLCCGDQSLGSTEIPLSGLLKKGSTEINQHPVTVEGAFTL
                     DPPNRAKQKLAPVPVELAPTVGVSVALQREGIGSQSLIELKTQNGHEPEHSQKRVLTP
                     IKEKTLTGPKSPRVSPAPPQNQTPPTKDDATESEVESLQYDKEPKQVVKGTGSIPASL
                     AQPEATGNPSEVVTSGQKIAVPATSHHFCFSIDLRSIHGLEISFPVNCILRYSYPFFG
                     SAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSK
                     DLLLGIARIQLSNILSSEKTRFLGANGEQCWRQTYSEKVPVIAAQGSNNRIVDLSYTM
                     TLEDYGLVKMREIFVSESSQGMSAVGQRASPPPPPPAPCPSEIQVEPRETLEYKAALE
                     LEMWKEMQEDIFESQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYSILEGKLQQ
                     ALTELESREQQLVTAETELQRERKELQLERERNLQELQDSVRRARDDCVHQVELERLK
                     LKQLEEDKHRLQQQLNDAENKYKILEKDFQQFKDQQNNKPEIRLQSEINLLTLEKVEL
                     ERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAE
                     EKDTVKTEQQELLDIRNELNRLRQQEQKQYQDYKEIASGKQGSPRGSGLEEGLDDYLT
                     RLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSASN"
     misc_feature    <662..1054
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <662..1054
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <1991..>2995
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1991..>2995
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            845..1072
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1289
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1467
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1617
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1800
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1897
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2056
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2146
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2239
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2401
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2524
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2623
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2769
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..4505
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgccct ttgtcctcca acctcccccg ggctctcggc ccgcgggcct ggttgctagg
       61 cggaagcggg gcgcggcggc gtccgctgcg gctgcccggg cgtttgaata gcggcttagc
      121 aggcggcaaa agaccccgcc gccacgacca tggtccccaa gtccgaccag ctgctcatcg
      181 tcgtatccat cctcgaaggt cgccatttcc ccaaacgtcc aaagcatatg cttgtggtgg
      241 aagcaaagtt tgatggggag cagttggcca ctgatcctgt cgaccatact gaccagccag
      301 aatttgctac tgagttagcc tgggagatcg acaggaaagt ccttcatcag cacaggcacc
      361 caaatggtac cagttgctga gtaacaaata caccaaattc aagtccgagg tacagataag
      421 catcactttg gaaacagata caaaggcaca ggtggatagt tttaaagcaa aaggagcccc
      481 acctcgggat ggaaaagttc ctgctagcct gttaggagtt gaccctaagg acatcgtggc
      541 agtgttgaat gaggagggag gctaccatca gattggacca gcagagtgtt gtactgactc
      601 ctttactctc tcagtgacca tagcatttgc cacccagttg gaacagttaa ttccatgtac
      661 catgaagctt ccagaaaggc agcctgagtt tttcttttac tattctttat tgggaaatga
      721 tgttacaaat gagccgttta gtgatttgat caacccgaac tttgagccgg agagggcgtc
      781 tgtccgcata cgaagcagcg tggaggtcct tcgtgtgtac ctggctcttc actcgaaact
      841 gcagatccat ctctgctgtg gagaccagtc actcggcagt acagaaatac ctctaagtgg
      901 attactgaag aagggcagca cagagattaa ccagcatcca gtcacagtcg agggtgcgtt
      961 tacccttgac cctccaaacc gagccaagca gaagctcgct cctgttcctg tcgagctggc
     1021 cccaactgtg ggagtgtcag tggctctgca gagagaaggc atcggctccc agtctttaat
     1081 tgaattaaag acccagaatg gacatgagcc tgagcactca cagaagagag ttttaacccc
     1141 cataaaggag aagacactca ctgggccaaa atcaccaagg gtgtcccctg ccccacctca
     1201 aaaccagaca cctccaacca aggacgatgc cacagaaagt gaagtggaga gcctgcagta
     1261 cgataaggag ccgaagcagg tggtgaaggg cactggttcc atacctgctt cgctggccca
     1321 gccagaggcg actggcaacc catcagaagt ggtgacatcg gggcagaaga ttgctgttcc
     1381 agcaacatca caccacttct gcttttcaat agacttgaga agcatccatg gcttggaaat
     1441 tagttttcca gtcaactgca tattgaggta ctcctaccca ttcttcggca gtgcagctcc
     1501 tattatgact aaccctcctg tagaagttcg gaagaacatg gaagtttttc ttcctcagtc
     1561 ttactgtgca tttgattttg caactatgcc tcaccagcta caagacacct tcctaaggat
     1621 tccactgctt gtagaactat ggcacaagga taaaatgagt aaagacttac tccttgggat
     1681 tgcaagaatt cagctttcta acatcttgtc ttcagaaaag acccggtttc taggtgctaa
     1741 tggtgaacag tgctggcgac agacttacag tgagaaagtg cctgtcatag cggcccaggg
     1801 gtcaaataac aggatagtag acctttctta cacaatgact ctggaggact atggcctggt
     1861 gaaaatgcgt gagatctttg tatctgagtc atctcagggc atgtctgctg tgggtcagag
     1921 ggcgtctcct cctcctcctc ctccagctcc ttgcccttct gagatccagg tggagccccg
     1981 ggagacctta gagtacaagg ctgcactgga gctggagatg tggaaagaga tgcaggagga
     2041 catatttgaa agtcagctga agcagaaaga actggctcac atgcaagctc ttgcagaaga
     2101 gtggaaaaaa agggaccggg aaagagagtc actagtgaag aaaaaggtag ctgagtacag
     2161 tattctagaa ggcaaacttc aacaagccct aacggagctc gagagccgag agcagcagct
     2221 tgtcactgca gagacagagc ttcaaagaga gagaaaggaa ctgcagttag aacgagagcg
     2281 gaaccttcaa gagctgcagg actctgtccg aagggccaga gacgactgcg tgcaccaagt
     2341 ggagctggag aggctgaagc tgaagcagct ggaagaggac aaacaccgcc ttcagcagca
     2401 gcttaatgat gctgaaaata agtataagat tttggaaaaa gattttcagc agttcaagga
     2461 ccaacaaaac aacaaaccag aaatacggct gcagtcagaa ataaacctcc tcaccttgga
     2521 aaaggttgaa cttgaaagaa agttggagtc tgcaaccaag tctaaactgc attacaagca
     2581 gcagtggggc cgagctttga aagaacttgc cagactcaag cagagggagc aagaaagcca
     2641 aatggctcgc cttaaaaaac agcaggagga gttggagcag atgcggctgc gttacctggc
     2701 tgctgaggag aaagacacag tgaaaactga gcaacaagaa ctgctggaca taaggaacga
     2761 actgaacagg ttacggcagc aagaacagaa acagtaccag gactacaaag agattgcaag
     2821 tgggaaacag ggcagccctc ggggctctgg gctggaagaa ggcctggatg actacttgac
     2881 acgtctgata gaagaacggg atactttgat gagaacgggt gtctataacc atgaggaccg
     2941 cataataagt gaactcgacc ggcagatcag agaggttttg acaaaaaaca gtgccagtaa
     3001 ttaaatgcat tgaggaagtc tttacagcta ctctaggtct gtgttttgaa ttttttgtaa
     3061 actcctcaaa agcaaggaaa acggcgactt tagagtgctc tttttaattt tttataagct
     3121 gaattttata tattactgta tatagtattt atttgatttt acttacgcta cctctccaat
     3181 gctggtttca tttgtaattg tattttatat gctcatttaa aatgactttt cagtgttctt
     3241 cagttcaaaa tctattgttt gactttaaaa acagcctttc agaacttatc ccaggagaac
     3301 tggccacagt agttcccagc tatataagtt ttttatgttg agtcaagaga gtatgtgttg
     3361 cactttaaaa atgctgtgcc ctgttccctt tgattgtaga tatcttcaaa ttaaagccaa
     3421 ttataagtgt agccattttt aaaaaagcat ttatatgacc agtctttttc ccttaacctg
     3481 tggtatttgc acatgacaac tttgaaaata aagcagtcac aggcagaaaa gctatgtgac
     3541 atgttggctg acaaattagt cattgcttaa atacagttca tgtagattaa gtttaaaaac
     3601 aaattcggaa tttcactgga ctccatttta agaatgtgag aaaacagctt gttctgatcg
     3661 cagcctcctg ctcacagctg catgaggctg gttgtcgtta aaattgtagg tcgcctttgt
     3721 ctctcagtgg tggcagtaca gcttcagaca gactgaggaa acagacacct agcgacatta
     3781 gctgagaaca ccttcctccc tctgcagtca ttctgttttc caagaggcag tgcagcgtga
     3841 gtcgtgtaag ccgcagagct tccctccgtg ttctccagac cacctcagcc tcatggcggc
     3901 actcatccct atgtctgcac aacaatgaac aggttagtga gcaaactccc agttcatgtg
     3961 cgatcttaaa acatagaaag taaaaattct gattccccaa aataacagat gtaagtgtat
     4021 ccttcggcaa gtatgagcta attaccagtc acttcagcat aagcaaagcg ggttacacgg
     4081 taatcttcac taggtgtgtt tctggtttgt gaaattaaag cctccatagg agtcatatgc
     4141 ttcttttctt taattttccg tctttgtctt ctaaaagcaa ctgagcagta aatcacagaa
     4201 aggctgctgg gtctgagggt ggtgagacag atgatcatag cagggatttg aaatatgaat
     4261 tatggttaca cggtcctgat tttcttggtg acatgaatgg agcaaaagga tttttgtttt
     4321 agaaggtcct ggcccaatgt tggttcttcc tcctgtatcc tgtgaggcct ggagcttttc
     4381 aaacactaga gggggcctaa gagtaagcag aaggacttct aaaatgtgtg tgtgctttgc
     4441 cttcaagaaa gccatctttg agctactgta atttgacaaa taaaatcctc actgcgtgca
     4501 tcctt
//
LOCUS       NM_001437241            5518 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus HR, lysine demethylase and nuclear receptor
            corepressor (Hr), transcript variant 2, mRNA.
ACCESSION   NM_001437241
VERSION     NM_001437241.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Kuramoto,T., Kuwamura,M., Tagami,F., Mashimo,T., Nose,M. and
            Serikawa,T.
  TITLE     Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair
            loss and exhibit focal glomerulosclerosis
  JOURNAL   Exp Anim 60 (1), 57-63 (2011)
   PUBMED   21325752
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Hsieh,J.C., Slater,S.A., Whitfield,G.K., Dawson,J.L., Hsieh,G.,
            Sheedy,C., Haussler,C.A. and Haussler,M.R.
  TITLE     Analysis of hairless corepressor mutants to characterize molecular
            cooperation with the vitamin D receptor in promoting the mammalian
            hair cycle
  JOURNAL   J Cell Biochem 110 (3), 671-686 (2010)
   PUBMED   20512927
  REMARK    GeneRIF: Hr and VDR interact via multiple protein-protein
            interfaces, catalyzing histone demethylation to effect chromatin
            remodeling and repress the transcription of VDR target genes that
            control the hair cycle.
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Hsieh,J.C., Sisk,J.M., Jurutka,P.W., Haussler,C.A., Slater,S.A.,
            Haussler,M.R. and Thompson,C.C.
  TITLE     Physical and functional interaction between the vitamin D receptor
            and hairless corepressor, two proteins required for hair cycling
  JOURNAL   J Biol Chem 278 (40), 38665-38674 (2003)
   PUBMED   12847098
REFERENCE   5  (bases 1 to 5518)
  AUTHORS   Fernandez,A., Silio,L., Noguera,J.L., Sanchez,A. and Ovilo,C.
  TITLE     Linkage mapping of the porcine hairless gene (HR) to chromosome 14
  JOURNAL   Anim Genet 34 (4), 317-318 (2003)
   PUBMED   12873232
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Potter,G.B., Zarach,J.M., Sisk,J.M. and Thompson,C.C.
  TITLE     The thyroid hormone-regulated corepressor hairless associates with
            histone deacetylases in neonatal rat brain
  JOURNAL   Mol Endocrinol 16 (11), 2547-2560 (2002)
   PUBMED   12403844
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Zlotogorski,A., Ahmad,W. and Christiano,A.M.
  TITLE     Congenital atrichia in five Arab Palestinian families resulting
            from a deletion mutation in the human hairless gene
  JOURNAL   Hum Genet 103 (4), 400-404 (1998)
   PUBMED   9856480
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Cichon,S., Anker,M., Vogt,I.R., Rohleder,H., Putzstuck,M.,
            Hillmer,A., Farooq,S.A., Al-Dhafri,K.S., Ahmad,M., Haque,S.,
            Rietschel,M., Propping,P., Kruse,R. and Nothen,M.M.
  TITLE     Cloning, genomic organization, alternative transcripts and
            mutational analysis of the gene responsible for autosomal recessive
            universal congenital alopecia
  JOURNAL   Hum Mol Genet 7 (11), 1671-1679 (1998)
   PUBMED   9736769
  REMARK    Erratum:[Hum Mol Genet 1998 Nov;7(12):1987-8]
REFERENCE   9  (bases 1 to 5518)
  AUTHORS   Thompson,C.C. and Bottcher,M.C.
  TITLE     The product of a thyroid hormone-responsive gene interacts with
            thyroid hormone receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8527-8532 (1997)
   PUBMED   9238010
REFERENCE   10 (bases 1 to 5518)
  AUTHORS   Thompson,C.C.
  TITLE     Thyroid hormone-responsive genes in developing cerebellum include a
            novel synaptotagmin and a hairless homolog
  JOURNAL   J Neurosci 16 (24), 7832-7840 (1996)
   PUBMED   8987811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            Summary: This gene encodes a protein that is involved in hair
            growth. This protein functions as a transcriptional corepressor of
            multiple nuclear receptors, including thyroid hormone receptor, the
            retinoic acid receptor-related orphan receptors and the vitamin D
            receptors, and it interacts with histone deacetylases. The
            translation of this protein is modulated by a regulatory open
            reading frame (ORF) that exists upstream of the primary ORF.
            Mutations in this upstream ORF cause Marie Unna hereditary
            hypotrichosis (MUHH), an autosomal dominant form of genetic hair
            loss in human. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.57889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000015.1  52036532-52036652
            122-717             JAXUCZ010000015.1  52038818-52039413
            718-1368            JAXUCZ010000015.1  52040641-52041291
            1369-2152           JAXUCZ010000015.1  52041944-52042727
            2153-2303           JAXUCZ010000015.1  52043839-52043989
            2304-2488           JAXUCZ010000015.1  52044075-52044259
            2489-2653           JAXUCZ010000015.1  52045901-52046065
            2654-2743           JAXUCZ010000015.1  52047412-52047501
            2744-2859           JAXUCZ010000015.1  52047650-52047765
            2860-2941           JAXUCZ010000015.1  52049011-52049092
            2942-3105           JAXUCZ010000015.1  52049725-52049888
            3106-3342           JAXUCZ010000015.1  52050003-52050239
            3343-3508           JAXUCZ010000015.1  52050443-52050608
            3509-3578           JAXUCZ010000015.1  52050813-52050882
            3579-3709           JAXUCZ010000015.1  52051160-52051290
            3710-3829           JAXUCZ010000015.1  52051432-52051551
            3830-3945           JAXUCZ010000015.1  52051646-52051761
            3946-4110           JAXUCZ010000015.1  52054044-52054208
            4111-4239           JAXUCZ010000015.1  52054444-52054572
            4240-5518           JAXUCZ010000015.1  52054733-52056011
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..5518
                     /gene="Hr"
                     /note="HR, lysine demethylase and nuclear receptor
                     corepressor"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
     exon            1..121
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            122..717
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    568..570
                     /gene="Hr"
                     /note="upstream in-frame stop codon"
     exon            718..1368
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..4302
                     /gene="Hr"
                     /EC_number="1.14.11.65"
                     /note="protein hairless; hairless homolog; hairless
                     protein; hair growth associated; [histone
                     H3]-dimethyl-L-lysine(9) demethylase hairless"
                     /codon_start=1
                     /product="lysine-specific demethylase hairless"
                     /protein_id="NP_001424170.1"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
                     /translation="MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLHHGALCLG
                     EPVPFWRGVLSAPDSWLPPGFLQGPKDTLSVVEGEGSRNGERKANWLGSKEGLRWKEA
                     MLAHPLAFCGPACPPRYGPLIPEHSSGHPKSDPVAFRPLHCPFLLETKILERAPFWVP
                     TCLPPYLMSSLPPERSYDWPLAPSPWVYSGSQPKVPSAFSLGSKGFYHKDPNILRPAK
                     EPLAASESGMLGLAPGGHLQQACDAEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPR
                     TPWPSCPPGLVHTLGNVWAGPGSNSFGYQLGPPVTPRCPSPGPPTPPGGCCSSHLPAR
                     EGDPGPCRKCQDSPEGSSSGPGESSEERNKAGSRASPPSHHTKLKKTWLTRHSEQFEC
                     PGGCPGKGESPATGLRALKRAGSPEVQGARGPAPKRPSHTFPGTGRQGARAWQETPET
                     STGSKAEAQQQEEQRGPRDGRIRLRESRLEDTSCQHHLAGVTQCPSCVQAAGEVEILT
                     SHSQKSHRLPLEEKPLEEDSCATSEEGGGSSPEASINKGLAKHLLSGLGDRLCRLLRK
                     EREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIAG
                     AGKNREKTGSREQRTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRG
                     HCFCQVDARVWAPGDGGQQKEPTEKTPPAPQLSCNGDSNRTKDIKEETPDSTESPAED
                     RAGRSPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILDSIIAQV
                     VERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTRLSPPGALLWLQEPRPKHGFRLFQE
                     HWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTSLDSTAFWKGFS
                     HPEARPKLDEGSVLLLHRPLGDKDESRVENLASSLPLPEYCAHQGKLNLASYLPLGLT
                     LHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSGL
                     DGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDSGLRR
                     RLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLCH
                     QGASLPPDHRMLYAQMDRAVFQAVKVAVGTLQEAK"
     misc_feature    1687..1890
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1993..2172
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2281..2385
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2434..2448
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: LXXLL motif 1"
     misc_feature    2842..2991
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3010..3024
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: LXXLL motif 2"
     misc_feature    <3997..4152
                     /gene="Hr"
                     /note="RmlC-like cupin superfamily; Region:
                     cupin_RmlC-like; cl40423"
                     /db_xref="CDD:477354"
     misc_feature    <3997..4152
                     /gene="Hr"
                     /note="RmlC-like cupin superfamily; Region:
                     cupin_RmlC-like; cl40423"
                     /db_xref="CDD:477354"
     exon            1369..2152
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2303
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2488
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2653
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2743
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2859
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2941
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3105
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3342
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3508
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3578
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3709
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3829
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3945
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4110
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4239
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..5518
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccccgc ccggattagt ggcagcttgg cctgactctc cggggctcct tcccccgccc
       61 tgcctgctgc ccacccctgg gcagggggct actctgcctg aggggcactg tgcttgccca
      121 gggtgctgga ggaggaaacc ggcggagcag cttccccact ctcagttgcg cgtctggcga
      181 tggcgatcag aggtcctgct gcgctctccg ctgcgctctc cctccattag ccgcgctacg
      241 cggtgctgcg ccctcgctgg tgcctcgctc ctggctcaca ggatcggccc cccacttcca
      301 ggcacgaccc ccttccccgg cccctcggcc tttcccccca ctcagccatc tccgacccgg
      361 ggcgcgcgtt ccccccggcc cggcttcttc tctccctccg gggacacccg ctccctagcc
      421 ccggttcgac cctccccaaa gcgcagcacg gagtctcggc gtcccatggc gcaacctaca
      481 gcctcggccc agaagctggt gcggcccatc cgcgccgtgt gccgcatcct gcaaatcccg
      541 gagtccgacc cctccaacct gcggccctag agcgcccccg acgcccgggg ggaaagagag
      601 cgcgagcgcg ctgagcagaa agcgggagaa cgccccgaag ccggcccatg gggagcgagt
      661 gcccagcacc ggcttgcacg accgccgccc acaccgcgcc cggcctgtga agcccaggac
      721 ccccccctgg gagagcccca tgagggtagg agagtgatgg agagtatgcc cagcttcctg
      781 aaggacaccc cagcctggga gaagactgcc cctgtgaacg gcattgtggg acaggagcct
      841 ggtacctccc cgcaggatgg cttgcaccat ggggcactgt gcctaggaga acctgttccc
      901 ttttggaggg gtgttctgag cgccccagac tcctggctcc ctcctggctt cctccaaggc
      961 cccaaggaca cactctcagt ggtggagggt gagggttctc ggaatgggga gaggaaagcc
     1021 aactggctgg gtagcaagga gggactacgc tggaaggaag cgatgctggc ccatccactg
     1081 gccttctgtg ggccagcatg cccacctcgc tatggccccc tgatacctga gcatagcagt
     1141 ggccatccca agagtgaccc tgtggccttc cggcccttgc actgcccttt cctgctggag
     1201 accaagattc tagagcgagc tcccttctgg gttcctacct gcttgcctcc ctacctgatg
     1261 tccagcctgc ctccagagcg ttcgtatgac tggcctttgg ccccaagccc ctgggtatac
     1321 tctgggagcc agccaaaagt gccctctgcc ttcagcttag gcagcaaggg cttttaccac
     1381 aaggatccaa acatcctcag gccagcaaag gagcccttgg cagcgtcaga gtctgggatg
     1441 ttgggcttag ctcctggagg gcatctccag caagcctgcg atgcagaagg cccctcgctt
     1501 caccagaggg atggggagac aggagctggc aggcagcaga atctttgccc agttttcttg
     1561 gggtacccag acactgttcc tcgaaccccc tggccttctt gtcccccagg cctggttcac
     1621 actctcggta acgtttgggc tgggccagga agtaacagct ttgggtacca gctaggccca
     1681 ccagtcacac caaggtgccc atcacctggg cctcccaccc ctccaggggg ctgttgctca
     1741 tcccatctgc ctgccagaga gggtgatcct ggcccttgta ggaaatgtca ggatagccca
     1801 gagggaagta gcagtgggcc aggggaatcc agtgaagaaa gaaacaaggc tggctccagg
     1861 gcctctcctc caagccatca caccaagctg aaaaagacct ggctcacacg ccactcggaa
     1921 cagttcgagt gcccaggtgg ctgtcctggg aagggagaga gcccagccac tgggctccgg
     1981 gcactcaaga gggcaggcag tccagaggtc cagggagcaa ggggcccggc tcccaaacgc
     2041 ccatcccaca ctttcccagg tactgggagg cagggggcca gggcttggca ggagacacca
     2101 gagacatcca caggaagcaa ggcagaggca cagcaacaag aggagcaaag agggccccga
     2161 gatggcagga ttcggctccg ggaatccaga cttgaggata catcctgcca gcatcactta
     2221 gcaggtgtca ctcagtgccc aagctgtgtc caggcagctg gagaggtgga gatactgacc
     2281 agccactccc agaaatcaca taggttaccc ctggaagaga agccgttgga ggaggattcc
     2341 tgtgccactt ctgaggaagg aggagggtct agcccagaag cttccatcaa caagggccta
     2401 gccaagcatc tactgagtgg tctgggtgac cgactctgcc gcctgctgcg gaaggagcgg
     2461 gaagccctcg cctgggcaca gcgtgaaggc caggggccag ccatgacaga ggacagccca
     2521 ggcattccac actgctgcag ccgttgccac cacggactct tcaacaccca ctggagatgt
     2581 tcccactgta gccaccggct gtgtgtagcc tgtggtcgca tagccggagc tgggaagaac
     2641 agggagaaaa caggctctcg ggagcagcgc acagatgact gtgcccagga ggctgggcat
     2701 gctgcctgtt ccctgattct gacccagttt gtctccagcc aggcgctggc agaactgagc
     2761 actgtgatgc accaagtctg ggccaagttt gacattcggg ggcactgttt ctgtcaagtc
     2821 gatgcccgtg tgtgggcccc cggggatggg ggtcagcaga aggaaccaac agagaaaact
     2881 cccccagctc cacaactttc ctgcaatgga gattccaatc ggaccaagga catcaaagaa
     2941 gagaccccag actccacaga gagcccagca gaggaccgtg ctggccggtc accacttcct
     3001 tgtccctctc tttgtgagct gctagcctct acagctgtca aactctgcct ggggcatgag
     3061 cggattcaca tggcctttgc cccggtcacc ccggctctgc ccagtgatga ccgcattacc
     3121 aacatcctgg acagcattat tgcgcaggta gtagaacgga agatccaaga gaaagccctg
     3181 gggccaggcc ttcgagcagg gtcaggctta cgaaagggcc tcagcctgcc cctgtcacca
     3241 gtgcgaaccc ggttgtctcc tcctggagct ctgctgtggc tgcaagagcc caggcctaag
     3301 cacggctttc gtctcttcca ggagcactgg cggcagggcc agcctgtgtt agtatcaggc
     3361 atccagaaga cattgagact tagcctgtgg ggaatggaag cccttgggac acttggtggc
     3421 caggtgcaga cactgactgc ccttgggccg ccccaaccca ccagcctgga cagcacagca
     3481 ttctggaagg gattctctca tcctgaggca cgtccaaagt tagatgaggg ctctgtcctc
     3541 ctgctacacc gacccctggg ggataaggac gagagcaggg tggagaacct tgcctccagc
     3601 cttccactcc cagagtactg tgcccaccaa gggaaactca acctagcgtc ctacctcccc
     3661 ctgggtctca cactgcatcc actggagccc cagctctggg cagcctatgg tgtgaactcg
     3721 caccgtggac acctggggac caagaaccta tgtgtggagg tgtctgacct aatcagtatc
     3781 ctggtgcatg ctgaggcaca gctgcctccc tggtaccgag cacagaaaga ttttctctca
     3841 ggcctggatg gggaagggct ctggtctcca ggtagccaga ccagcactgt gtggcatgtg
     3901 ttccgagccc aggatgccca gcgtatccgt cgctttctcc agatggtgtg cccagctgga
     3961 gcaggaacct tggagcctgg tgccccaggc agctgctact tggattcagg gttgcgacgc
     4021 aggttaaggg aggagtgggg tgtgagctgc tggacactgc tgcaggctcc tggagaagcg
     4081 gtgctggtgc ctgctggggc accccatcag gtacagggct tggtgagcac aatcagtgtc
     4141 actcagcact ttctgtctcc tgagacctcg gccctctctg ctcagctctg ccaccaggga
     4201 gccagcctgc cccctgacca tcgtatgctt tatgcccaga tggaccgggc tgtgttccaa
     4261 gcagtgaagg tggcggtggg gacattacag gaagctaaat aggggaccct ggtgcctgga
     4321 gggggcgggg gtggagcagg taactgagtg ttcagtctgc atgatttcag cggggaatgg
     4381 tactgtggaa cttaggtggt gtgatccgtt ctacaaatat ctctttgggt acaagcaggg
     4441 aaccctgttc cctcaccctg gccctggctc taaagggaac aactgtagtg cttacagccg
     4501 ctcccctctc cacggtatca ggttcaccct aggggtccat gactccttct aagccccact
     4561 ccaggggata agtacccttc cttggggaag cttgggaatt gttttagttt aagcaacact
     4621 tcctctggct gcttcaccct gtgttctccc tggcatcccc acgcccaccc ctggctgtgc
     4681 tacagctcac cagcatccac acaaagttcc gactgtaggt gtgctggacc gggagccaca
     4741 gaattcttcc cttactgtgg agttggggag gagaggacct cagttaatgg gccatactgg
     4801 ctggagggaa caccatgggc agaaccactg ggtcccccgc ttctgcctct ctccttccct
     4861 gtcactgtta aaattggttg ttcagtgact gctgccagca tagttggcct cactctgctg
     4921 gccacgtggg ctagggggaa aaggcaaaca cagaaatctg atctggagca gaagccagtg
     4981 gacagggtga gaagggactg ggggacctgg tgacagagac ctcacatacc actgccagat
     5041 ctttgggagc ccccctggag ctttctgggg actgaagatg ttcctgactt acagagggaa
     5101 ggcagagttc taaggacagc actgagatag cctccctggg tggcatcaac ctgtggagat
     5161 tacagaaccc cctgcctctg tcccacctgt cctgtgcgtt ctgacttgga gagacatcca
     5221 ggatagccct ggctcaaccc aactactctt ggtgtccaag ccaccaggac agagcttcac
     5281 tgcctcaaac agctgacccc taccctcatg gcccttctgg tgccaacagc tgacccctac
     5341 cctcatggcc cttctagtgc cagcagctga ccccatcccc acggccctct ggtactgcct
     5401 tgtctcctac ctcttccttg tgtatctcaa ccgcacacat gcgccagctc ttgttatact
     5461 taacagttcc tgctgtggtt tggggatttt tttttaatta aataaaagtt tttattat
//
LOCUS       NM_001437299             777 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 6, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437299
VERSION     NM_001437299.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.3010172.1,
                                           SRR26360172.2825189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-286             JAXUCZ010000011.1  44823308-44823443
            287-777             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..777
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            151..286
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..479
                     /gene="Mrps6"
                     /note="isoform 4 is encoded by transcript variant 6; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 4"
                     /protein_id="NP_001424228.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGYFLVDFYAPTN
                     AVESMLEHLARDTDVVRPNIVKHPLTQEVKECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    <189..389
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    <189..389
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(234..236,240..248,288..290,294..296,369..371,
                     381..383)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(234..236,240..248,288..290,294..296,369..371,
                     381..383)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(246..248,258..260,315..317,324..329,348..350,
                     369..371,378..386)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(246..248,258..260,315..317,324..329,348..350,
                     369..371,378..386)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     exon            287..777
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg agaccgctgc tgctttaaaa cgtacaatag
      181 aatccctgat ggaccgagga gccatagtga ggaacttgga aaacctgggt gagcgtgcac
      241 tcccatacag gatctccagt cacagccagc agcacagccg aggagggtat ttcttggtgg
      301 atttttatgc cccaacaaat gctgtggaaa gcatgctgga acacttggca cgagacactg
      361 atgtggttag accaaatatt gtgaaacacc ctctgaccca ggaagtaaaa gagtgtgacg
      421 gcatagtccc agtccctctt gaagaaaaac tgtattcaac aaagagaagg aagaagtgag
      481 aagattcacc agatgtggct atgttcaatt ctaagtgcac catgggtgct gataggtttg
      541 tctaggatgc tttagcccgt gaccattttg ctgcagatgg ggactgctgg ccgagacctg
      601 ctctgtcacc cctgctgata tttcaccctc actgtgtgat tgtcagggtg cggtggggct
      661 ggtgttcaca gtcccactgc agagtttcga agaacaaaat gtttgtcatt cacactcggt
      721 tgtcttgtaa acctgtgtgg aacacagagc agagtaataa acatggtttt atcaaca
//
LOCUS       NM_001437318            4594 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), transcript
            variant 5, mRNA.
ACCESSION   NM_001437318 XM_063271261
VERSION     NM_001437318.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271261.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.47099.1,
                                           SRR26643291.32028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000012.1  16568376-16568466
            92-227              JAXUCZ010000012.1  16579863-16579998
            228-358             JAXUCZ010000012.1  16584164-16584294
            359-997             JAXUCZ010000012.1  16586628-16587266
            998-1074            JAXUCZ010000012.1  16588652-16588728
            1075-1177           JAXUCZ010000012.1  16591172-16591274
            1178-1342           JAXUCZ010000012.1  16592806-16592970
            1343-1457           JAXUCZ010000012.1  16597507-16597621
            1458-1597           JAXUCZ010000012.1  16598234-16598373
            1598-1648           JAXUCZ010000012.1  16602723-16602773
            1649-1786           JAXUCZ010000012.1  16604251-16604388
            1787-1935           JAXUCZ010000012.1  16609121-16609269
            1936-2014           JAXUCZ010000012.1  16609681-16609759
            2015-2112           JAXUCZ010000012.1  16658476-16658573
            2113-2335           JAXUCZ010000012.1  16670103-16670325
            2336-2405           JAXUCZ010000012.1  16687074-16687143
            2406-4594           JAXUCZ010000012.1  16687679-16689867
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4594
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..91
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            92..227
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="upstream in-frame stop codon"
     CDS             161..2722
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 5; E3
                     ubiquitin-protein ligase RNF216"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216 isoform 2"
                     /protein_id="NP_001424247.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTEDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTV
                     SPRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEY
                     WLDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPG
                     PASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLV
                     KETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLAS
                     QDDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAIT
                     RKAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRH
                     CRSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYG
                     EFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLP
                     QTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKC
                     QGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCR
                     CGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAE
                     EEQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPP
                     VRPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     misc_feature    1661..1831
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1661..1831
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1928..2083
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    1928..2083
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2114..2284
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     misc_feature    2114..2284
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     exon            228..358
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            359..997
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1074
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1177
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1342
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1457
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1597
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1648
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1786
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1935
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2014
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2112
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2335
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2405
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..4594
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcggcc tcggcggcag cggcggcggc gacgacagca ttggcagtgg cggctgtagc
       61 agcggggaag cttttcgagc ggatgcttca gaccctacag aacagatgat caccatgtct
      121 gggttctagc aatcacatac gtttatatct gaatttgaaa atggcagagg gaaacaacca
      181 agaggaggtc attcacttga acaactttca ctgccaccgg gggaaggagt ggatggctgt
      241 cagagagggg cccatcacca tatctgactc ctctgatgag gaagggattc caatgctggt
      301 taccccggct actgagcaac aggaagacga cctggatgat gatgtcatcc tgacagaaga
      361 tgattctgag gatgaatgtg gtggatttct ggatcttaag actgagaaaa aaggaggaga
      421 agccaaacct ggaccaagca ataagcagac agcagacaat actgtcagcc ccaggctgga
      481 gcagaaagtc attattttgg gagaaaatgg tcttcttttt tcagaaagtg agcctctgga
      541 agttcagaac caattatctg aagactcaga gacagatctt ttatcaaatc ctggtgagcc
      601 agctgcctca gtagatgagc agctaattga agaagagtac tggcttgacc atccctactt
      661 ccaggctctg aatccacagc ctcaggagag aacaaaccag cttgtgcccc aagagcgaca
      721 ttctgaatca gaaatgggcc caatgttttt ccgccatgat ttcccggagc cagcttttcc
      781 aaggccagaa ccccagcagg aggggattcc aggacccgct tctccacaac cagcccatcc
      841 tctaggagag cttgaagacc agcaattagc aattgatgaa gaccctgggc ctgcctaccc
      901 cctgccagga ccccaggagg ccaatttggc aaatgtgtgg ggacaagaag ctgctgaagg
      961 ggatcaagag ctcattccac tgttagtgaa agaaacggaa gcaagatttc cagacgtagc
     1021 aaatggatat gttgaagaga taattcattt gaaaaattac tatgatttga atgtactttg
     1081 taattttctc ctggaaaatc cagattatcc aaagagagaa gaccgaatcc ttatccaccc
     1141 cagcagtagc ctgcttgcca gccaggatga tgtgaagttg cctaagatag acttttttga
     1201 ctattccaaa ttgactccac ttgaccagcg ctgcttcatc caagctgctg acctcttgat
     1261 ggctgatttc aagatgctca gcagccagga catcaagtgg gccctgcacg agctcaaagg
     1321 gcattacgca atcacccgaa aggccttttc tgatgccatt aaaaaatggc aggagctatc
     1381 acctgaaacc agtggaaagc ggaaaaagag gaaagaaatg aatcagtatt ctttcataga
     1441 cttcaaattt gaacaaggta acataaaaat agaaaagagg atgttctttc tggaaaacaa
     1501 gcgtcgacac tgtaggtcct atgaccagca ggccctcctt ccagctgtgc agcaagagca
     1561 ggagttctat gagcagaaaa ttaaagagat ggcagagcac gaagattttt tgcttgccct
     1621 gcagatgaat gaagagcagt atcaaaagga tggccagctg attgaatgcc gctgctgcta
     1681 tggggagttt ccatttgagg agctgacaca atgcgctgat gctcacttgt tctgcaaaga
     1741 atgtctcatc agatatgccc aagaggccgt gtttggatct ggaaagtcag agctcagctg
     1801 catggaaggc agctgcacat gttccttccc aaccagtgaa ctggagaaag tgctccccca
     1861 gaccattctg tacaaatact atgaacggaa agctgaagag gaagtcgcag cagcctatgc
     1921 tgacgagctt gtccggtgcc cctcttgcag cttccctgct ctgttggaca gcgatgtgaa
     1981 gaggttcagc tgccctaacc ctcgctgccg aaaggagacc tgtaggaagt gtcagggact
     2041 ctggaaagaa cacaatggcc tcacctgtga agagctggca gaaaaggatg acatcaagta
     2101 ccggacatct attgaagaaa aaatgactgc tgctcgaatt agaaaatgcc acaagtgtgg
     2161 gactggcctc atcaaatctg aaggctgcaa ccgcatgtct tgccgctgtg gtgcccagat
     2221 gtgctacctc tgtcgagttt ctatcaatgg ctatgaccac ttctgccagc atcctcgctc
     2281 tccaggagcc ccttgccagg aatgttccag gtgctccctc tggaccgacc ccactgaaga
     2341 tgatgagaag ctgattgagg agatccaaaa ggaggctgag gaggagcaga aaagaaagaa
     2401 tggagagaac actttcaaac gcatcgggcc cccactggag aagccggctg agaaagtgca
     2461 gcgtgtggaa gccctgccac ggcctgtccc acagaacctg caccctcaga tgccacccta
     2521 tgcctttgtc cacccaccct tccccctgcc acctgtgcgg cccgtgttca acaacttccc
     2581 catcaacatg ggtcctgtgc ccgcacccta tgtaccccct ctgcccaacg tgcgtgtcaa
     2641 cttcgacttt ggccacgtgc atgtgcccct ggagcacaac ctgcccatgc actttggccc
     2701 ccaaccacgg catcgcttct gacacccaaa gccctgtcca gctgtgctga gtctgcagga
     2761 ggacccagtc tcatcctctg agtagggatg aagtcctcga ctccctatgg ggtgtgggct
     2821 cgtgtcctcc tgctcttccc gttgcgaggt ccactgctcc ttcgggtctg atgcgccttg
     2881 ggtgctgact gtcgctgcac cagtaatagg gcagctcccc gggtctgcca tctatcttag
     2941 cagccagtcc aggggccttg gccgagaagc aggcccttta agcatttgcc atacttcctc
     3001 cccagcagac cactgaaagc ccaagggaaa atggcctacc ctccccaggc cagggctctc
     3061 tccttgttgc ccaaggccca ctcaggtcca agggccgcca agaatcttct gtggcgcaag
     3121 ttttgttctg ttgttaccta gaggttgctc ctattcacat agtttgagct gaagtttttt
     3181 gtgtgtcccc atccgtggaa agtcaggttg aaggtatttc cccagggctg gcaactgctg
     3241 agaaccagta gtcctgacac ttgacatcaa acagaaggac ccttttaggg ccctttattc
     3301 ctgggctgcc ccttttctgg gagagacctc acttgtcacc aacctgggat gagcagcatc
     3361 tctcctaagg tttttagggg cttccctagc agtgcagatg acctcatgga gctgctgcag
     3421 ctatcacagc aaccctcctg cccgctcagc tgtccctcac tagttagcag tggatgcaga
     3481 caggagaggt ctagctccaa gatgaggaca gctggcttcc ctagagtcag atgaaaatcg
     3541 gcctgcacag tctttgccat gttcccacta cctgtgtccc ctcctgtcca gaccagatct
     3601 ttatactctc ctccagtgtg tgttgaccag ggctgatagc aagtgtctca ctcagttgta
     3661 ctggctgtcc ttgtcgtgga gtgtcccatg ttcagagtgt acagacttag aagagagaag
     3721 atgtccctgg gaaaaggaaa gactccctga ggtgcccact gtcactggag tgtgggtagg
     3781 gcacacaggg caactcagga gccctgccat gggtcacctg aactgtgatg ctagtctgaa
     3841 tgacagtgcc ttggaaagat gggccacatg ctgcatgaca ggatcctcca agtaccttaa
     3901 caattagtgt actcgtgttc tctgcacttc tccagaagcc ctgcaggggg cggtactccg
     3961 agcactgccc ctccaaggcc tcatgagccg ctggactggg cacccagttc tgggcgcctc
     4021 agtaccctat cacattgttc caccaagagg ccagatggaa aaactggcag tttctggggt
     4081 agctggaaga gcaggccagg caggtgccat ccagaccctg gcactccatt tggagaggtg
     4141 aggccagaga cgtatccttc aaaatattgt cagtctgtga cagggagact gctactgcct
     4201 gtctccatca aggagtgacc ctcccatgtt gccagcaggg ctagggagtg aggggtgggc
     4261 cagcaaggat ccccaaggca gctgccacct taacccctag gacccagact gcttcctggt
     4321 ttaagaaact gcctagccac tcccagtgta tttgccttaa aactggagag aatctagtat
     4381 ttgcacttag caaaagattt caaagttaag agaaaagtgc atgatctcac tttgtacaaa
     4441 agaaaaaaag gaaaaaaaat gaagtagatg gttaaacgtt tttctttacc ttttggtagt
     4501 aaaaatagag aaaacaagtc tgtttaaact actgtgtaaa aagactgtat catatgtaac
     4561 ttgaattttg tgtaaataaa tgtttgtgaa cgct
//
LOCUS       NM_001437395            1611 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 68 (Ccdc68),
            transcript variant 3, mRNA.
ACCESSION   NM_001437395 XM_039096658
VERSION     NM_001437395.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096658.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.56810.1,
                                           SRR26360190.3140741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000018.1  65817263-65817401
            140-268             JAXUCZ010000018.1  65830762-65830890
            269-355             JAXUCZ010000018.1  65832026-65832112
            356-490             JAXUCZ010000018.1  65837996-65838130
            491-616             JAXUCZ010000018.1  65840508-65840633
            617-745             JAXUCZ010000018.1  65841071-65841199
            746-828             JAXUCZ010000018.1  65848350-65848432
            829-934             JAXUCZ010000018.1  65852302-65852407
            935-1018            JAXUCZ010000018.1  65853741-65853824
            1019-1095           JAXUCZ010000018.1  65856970-65857046
            1096-1611           JAXUCZ010000018.1  65859014-65859529
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1611
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="coiled-coil domain containing 68"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
     exon            1..139
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    77..79
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="upstream in-frame stop codon"
     exon            140..268
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1153
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="isoform 3 is encoded by transcript variant 3; CTCL
                     tumor antigen se57-1; coiled-coil domain-containing
                     protein 68"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 68 isoform
                     3"
                     /protein_id="NP_001424324.1"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
                     /translation="MTTVTVTMEVPSGGKTEDRSIFSGPSSAQIIEETEYVRKIRTTL
                     EKIRNRMFKEEDGRGNARHKVDAEQSGNVQNGLDSTTDPTRLDLLLESMRRKDQQLLE
                     MNKENEVLQIKLEASREAGAAALRNAAQRLFDNYQTQSEDLEKKHKDSKHVLQVNKLE
                     KEQTLKQRAKNLSQLSEKLGEKHEQIVGLENRVQRMENEKKALLERKLCLESKLLQLK
                     SNAANSKSCQHLQTEISILQEQICHLQFVIHSQHQNLRNIIQEMEGLKNTLKEQDKKI
                     ENLKEKVTVLEAQNEELKTKVAHWTESPRTSVSKAVSTSELKTEGASPYLMLIRLRK"
     misc_feature    <404..>1042
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <404..>1042
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            269..355
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            356..490
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            491..616
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            617..745
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            746..828
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            829..934
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1018
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1095
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1611
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgggaca ctggactctg ccctgggcgc gcctatctga gcacttaggt gctctcagtc
       61 gccaaacttc agcagttaag gacccgacgg tgggctctct gccagatcgc tggaactgga
      121 gcaggcggag gccttcaagc cagaattcac catgacaact gtcacggtga ccatggaagt
      181 tccttctggg ggtaagacag aagaccgctc catcttcagt ggaccgtcgt cagctcagat
      241 tattgaagaa actgagtatg tgagaaagat tcgaactacc ctggaaaaga tccggaatcg
      301 catgtttaag gaggaagacg gccgaggcaa tgcaaggcac aaagtagatg cagagcaatc
      361 tggaaatgtt cagaatggct tggattctac aacagacccc accaggttgg atttgctctt
      421 ggaaagcatg agaagaaaag atcagcagct cctagaaatg aacaaagaaa acgaagtgtt
      481 gcaaatcaag ctggaagctt cccgagaagc aggagcggca gctttgagaa atgcggctca
      541 gagattattt gacaactacc aaacgcagtc tgaagacctg gagaaaaagc ataaggacag
      601 taaacatgta cttcaggtca acaaactcga gaaagagcag acgttaaagc aacgtgccaa
      661 aaatctgagt caactttcag aaaaactggg agaaaaacat gagcaaatcg taggactgga
      721 aaaccgtgtc cagaggatgg aaaatgaaaa gaaagcactc ctagagagaa aattatgttt
      781 agaaagcaag ctactccagc tcaagtccaa cgctgcaaat tcaaaaagct gccagcatct
      841 tcaaacggag atttccatcc tccaggagca gatctgtcat ctgcagttcg tgatccactc
      901 ccagcaccag aacctgcgca acatcatcca ggagatggaa ggactaaaaa atactttaaa
      961 ggaacaagat aaaaaaattg aaaatttgaa agaaaaggtc accgtgctcg aagcccagaa
     1021 tgaagaacta aaaaccaagg tggcacactg gacggaatct cctaggacat cagtatctaa
     1081 ggccgtctct acaagtgagt tgaagactga aggtgcttct ccctatttga tgttgattcg
     1141 gctacgaaaa tgagctggct ggctgcagtt ctgacagaga aggacttcta cagattttat
     1201 ttattccttg aaatacagtt tcagctccca agttaaagtg acatcatgtc ttatctaaat
     1261 gtaacttagt atacatcaat aacggcatag aaaggtgata ttgcaggcaa ttcaacaaat
     1321 gtctcctgga gagaagaaac ctttttcttt ttaaaccaaa atgtaactta aaaggccaag
     1381 ggactaggat ctttcccaca tggaagatga attctgcttt aaacctaaaa tattaaaatt
     1441 tgaatctatc tctcttcaaa cattttacaa agaggactct tataaggttg tcagatttga
     1501 cctttgatag tggttcttat gtgtataaat aaagggaagt atgtaaatat atattaatga
     1561 atgatgtaat ttaatttggc atttaggtaa taaatatctt accatgccac a
//
LOCUS       NM_001437300            1159 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 7, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437300
VERSION     NM_001437300.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.612492.1,
                                           SRR26643293.68573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               JAXUCZ010000011.1  44781963-44782490
            529-668             JAXUCZ010000011.1  44823304-44823443
            669-1159            JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1159
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..528
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    523..525
                     /gene="Mrps6"
                     /note="upstream in-frame stop codon"
     exon            529..668
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..861
                     /gene="Mrps6"
                     /note="isoform 4 is encoded by transcript variant 7; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 4"
                     /protein_id="NP_001424229.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGYFLVDFYAPTN
                     AVESMLEHLARDTDVVRPNIVKHPLTQEVKECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    <571..771
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    <571..771
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(616..618,622..630,670..672,676..678,751..753,
                     763..765)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(616..618,622..630,670..672,676..678,751..753,
                     763..765)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(628..630,640..642,697..699,706..711,730..732,
                     751..753,760..768)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(628..630,640..642,697..699,706..711,730..732,
                     751..753,760..768)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     exon            669..1159
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcctcg gaccccggct ctccggagtc cgatggaagg actgcgggag gacacacgcg
       61 cgagaaccca ggccggcccc gctctgcgcc cacgggtcga gaagctgctc gtcgtcccga
      121 tcgcctgccc tcagcgtccg cgatcagtac agccttccac caaagcccgc cagtgccggc
      181 tgtgtacccc acgcacttgt caccgctgtc acgctaaaaa aaaaaatctt ttgacctttc
      241 tttttctgac tccagcgaaa atcctgctcc gggtaccctt agcccagttt tattcatcca
      301 agttgtggcc ttgcttgtgc tttccgaaga cgtgtcttcc cccagctttt gattgatctt
      361 gaggtaggga ctttcaggtt tggagggatg ataaaccacc agcagccggg tcacggactg
      421 gggtcagcgg tggaggcagc tatcttcgtc ctctgttctg agtcaggcac ttctcaatcg
      481 tcgctgaaat ccccattctt ctgagagaat tcggtaacgt agtagcagcc agagaccgct
      541 gctgctttaa aacgtacaat agaatccctg atggaccgag gagccatagt gaggaacttg
      601 gaaaacctgg gtgagcgtgc actcccatac aggatctcca gtcacagcca gcagcacagc
      661 cgaggagggt atttcttggt ggatttttat gccccaacaa atgctgtgga aagcatgctg
      721 gaacacttgg cacgagacac tgatgtggtt agaccaaata ttgtgaaaca ccctctgacc
      781 caggaagtaa aagagtgtga cggcatagtc ccagtccctc ttgaagaaaa actgtattca
      841 acaaagagaa ggaagaagtg agaagattca ccagatgtgg ctatgttcaa ttctaagtgc
      901 accatgggtg ctgataggtt tgtctaggat gctttagccc gtgaccattt tgctgcagat
      961 ggggactgct ggccgagacc tgctctgtca cccctgctga tatttcaccc tcactgtgtg
     1021 attgtcaggg tgcggtgggg ctggtgttca cagtcccact gcagagtttc gaagaacaaa
     1081 atgtttgtca ttcacactcg gttgtcttgt aaacctgtgt ggaacacaga gcagagtaat
     1141 aaacatggtt ttatcaaca
//
LOCUS       NM_001437324            8671 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            2 (Jakmip2), transcript variant 1, mRNA.
ACCESSION   NM_001437324
VERSION     NM_001437324.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8671)
  AUTHORS   Cruz-Garcia,D., Vazquez-Martinez,R., Peinado,J.R., Anouar,Y.,
            Tonon,M.C., Vaudry,H., Castano,J.P. and Malagon,M.M.
  TITLE     Identification and characterization of two novel (neuro)endocrine
            long coiled-coil proteins
  JOURNAL   FEBS Lett 581 (17), 3149-3156 (2007)
   PUBMED   17572408
  REMARK    GeneRIF: NECC 1 & 2 proteins primarily expressed in
            (neuro)endocrine tissues in vertebrates thus supporting a role for
            these proteins in the regulated secretory pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1350845.1,
                                           SRR26643298.73922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000018.1  35998552-35998896   c
            346-622             JAXUCZ010000018.1  35901780-35902056   c
            623-1120            JAXUCZ010000018.1  35893106-35893603   c
            1121-1330           JAXUCZ010000018.1  35889442-35889651   c
            1331-1429           JAXUCZ010000018.1  35887501-35887599   c
            1430-1576           JAXUCZ010000018.1  35883648-35883794   c
            1577-1717           JAXUCZ010000018.1  35882878-35883018   c
            1718-1774           JAXUCZ010000018.1  35880934-35880990   c
            1775-1894           JAXUCZ010000018.1  35879957-35880076   c
            1895-2023           JAXUCZ010000018.1  35878661-35878789   c
            2024-2107           JAXUCZ010000018.1  35876787-35876870   c
            2108-2170           JAXUCZ010000018.1  35876036-35876098   c
            2171-2269           JAXUCZ010000018.1  35872906-35873004   c
            2270-2368           JAXUCZ010000018.1  35871950-35872048   c
            2369-2422           JAXUCZ010000018.1  35871138-35871191   c
            2423-2488           JAXUCZ010000018.1  35870288-35870353   c
            2489-2557           JAXUCZ010000018.1  35866017-35866085   c
            2558-2635           JAXUCZ010000018.1  35856809-35856886   c
            2636-2839           JAXUCZ010000018.1  35854261-35854464   c
            2840-2905           JAXUCZ010000018.1  35848371-35848436   c
            2906-2976           JAXUCZ010000018.1  35845323-35845393   c
            2977-8671           JAXUCZ010000018.1  35833986-35839680   c
FEATURES             Location/Qualifiers
     source          1..8671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..8671
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="janus kinase and microtubule interacting protein 2"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
     exon            1..345
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            346..622
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    482..484
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="upstream in-frame stop codon"
     CDS             494..2956
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     2 isoform 1"
                     /protein_id="NP_001424253.1"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
                     /translation="MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKV
                     SKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSR
                     TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLK
                     TAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR
                     IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHC
                     SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLA
                     KRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL
                     KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMT
                     SFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAERE
                     AKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAE
                     NHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGV
                     KDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMM
                     ELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLS
                     DKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQI
                     KDLEEKFLFLFLFFSLAFILWP"
     misc_feature    548..>2293
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    548..>2293
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    1718..2299
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1718..2299
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1925..>2905
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    1925..>2905
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            623..1120
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1330
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1429
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1576
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1717
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1774
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1894
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2023
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2107
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2170
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2269
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2368
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2422
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2488
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2557
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2635
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2839
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2905
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..2976
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..8671
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctaccg cagcaggggt ggggctgtgg gggtggggag ggaaggagga gcctgaggag
       61 gtgtctgctg caagttcctg gctgattctg agctcacacc atcctccaag agggaggagg
      121 ctcaagtgat gctgctgctg ttgccgcctc tactgctggt actctagtgg agctgggaag
      181 ggtggttcct atcgcaccat cgccaaccgg agagggaggg ggaaaaaaat cctggtagcc
      241 gctgctgatg ttgggttcag aggctgcatc cgacccggtc acaagaaaaa tggattcagt
      301 gtgcggctct ccctcttttc agcatcttct cctgctctca acatgggctt ccgaggcagc
      361 gtttgagaag accttagcaa ggaacaccaa gcagtagtgg ctgaaacacc tcactccagg
      421 aaatgaaaca gtaacatggc agtacctgtt tgagaggatt aaaaccccaa aagactccat
      481 ttagaaaggg acaatgtcca aaaaaggacg aaataagggc gagaagcccg aggcactcat
      541 tgttgccctt caagctgcca atgaagacct caggaccaaa ctcacagaca ttcagataga
      601 acttcatcaa gagaaatcca aggtatcaaa gcttgaaaga gagaagactc aagaagcaaa
      661 gaggattcgt gagctggagc agcgcaaaca cacagtcctg gtgacagagc ttaaagccaa
      721 gctccatgag gagaagatga aggagctgca ggctgtgagg gagaatctca tcaagcaaca
      781 tgagcaggaa atgtcaagga cagtgaaggt gcgggatgga gagattcaga gactcaagtc
      841 cgctctgtgt gctctccgcg atggcagcag tgacaaagta aggacagcac tcaccattga
      901 ggcccgggag gaggccagga aacagttcga tgcagagcgc ctgaagctcc tgcaggaaat
      961 tacagactta aaaaccgcca agaagcaggt ggatgaggct ctgagcaata tgatccaagc
     1021 ggataaaatc aaggctgggg accttaggag tgagcatcag tcccaccagg aagccatctc
     1081 gaagatcaag tgggaatcgg aacgggatat acgaaggctg atggatgaaa tcaaagccaa
     1141 ggacaggatc atcttctccc tggaaaaaga actggagact cagacaggct atgtacagaa
     1201 actccagcta cagaaagagg ctttggatga gcagctcttc cttgtcaagg aggcagagtg
     1261 taacatgagc agtccgaaga gagagattcc aggaagggca ggggatggct ctgaacactg
     1321 cagcagcccg gatttgcgaa gaaatcaaaa gagaatagcc gaattgaatg ccactatacg
     1381 aaagttagaa gacaggaaca ccttgctcgg agatgaacga aacgagttgt taaaacgtgt
     1441 gcgggaaact gaaaaacaat gcaaacctct cctggaaagg aacaagtgcc tagccaagag
     1501 aaacgatgaa ctgatggtat ctctacaacg catggaagag aaattaaaag ccataaccaa
     1561 ggaaaattca gagatgagag agaaaataac gtctcaccca ccattgaaga aactgaagtc
     1621 tctgaatgac cttgatcaag ctaatgaaga acaagagacg gagtttctaa aactgcaggt
     1681 cattgagcag cagaacatca ttgatgagct caccagggat cgagaaaaac tcatccgtag
     1741 gagaaagcac aggagaagct cgaaaccaat caagaggcct gttttagatc cgttcattgg
     1801 ctatgatgag gattcgatgg attcagaaac atcatccatg acctccttta gaacagaccg
     1861 gacacctgct accccggatg atgacttgga tgaaagtcta gctgctgaag aatctgagct
     1921 acgatttcga caattaacaa aagaatacca agccctccaa agagcatatg ccctcttgca
     1981 ggaacagact ggaggcatca tagatgctga aagagaagcc aaggcacaag agcagctcca
     2041 ggcagaggtg ctgaggtaca gggccaaaat cgaagatttg gaagcaacgc tggctcagaa
     2101 agggcaggat tcacactggg tagaagataa acaacttttc attaagagaa accaggagct
     2161 tttagaaaag atagagaagc aggaagcaga gaatcaccgg ctacagcaag aacttcagga
     2221 tgccagagac cagaatgagc tgctggagtt tcgcaaccta gaactagaag agagagagag
     2281 gcgatcccct ccattcaatc tacaaattca ccccttctca gatggtgtga gtgcactgca
     2341 gatctactgc atgaaagaag gtgtcaagga tgtcaacatc cctgatctca taaagcagct
     2401 tgatatcctt ggtgacaacg ggaatctaag gaatgaagaa caggtggcca taattcaggc
     2461 cagcactgtg ctgtccctgg cagagaagtg gatccaacaa attgaaggag cagaggctgc
     2521 cctgcaccag aaaatgatgg aactggaaag tgatatggaa caattctgta aaatcaaagg
     2581 ctacctggag gaagaactag actacagaaa acaggctctt gaccaggcat atatgagaat
     2641 ccaggaacta gaagctactt tgtacaatgc tctgcagcaa gaaactgtga tcaagttcgg
     2701 tgaactgtta agtgacaagc agcaagagga gttgaggacg gctgtagaaa agttacggcg
     2761 gcaaatgctg aggaagagcc gggaatatga ctgtcagatc ctccaggaga ggatggagct
     2821 cctacagcaa gctcaccaga ggatccgtga cctagaagat aaaacagaca tccaaaaacg
     2881 gcagataaag gacctagaag aaaagtttct gtttctattc ttgttcttct ctcttgcctt
     2941 cattctatgg ccttgatgtc aaggtgcctc ttaaagaaaa atcaagaact tggatcatac
     3001 cccaagaagg caaatgcttt taaaccttca aagatggcaa aattgtttac accgatgtaa
     3061 gggaaatcaa aagctaagaa ttaccctgta gccaagacta tgagctttaa agccattatt
     3121 caaggtttct tacttgacag tttataatga ccctgttgaa aaatctacat tatatgctgc
     3181 aattaatgaa acgtgtgtat gtcaaaccgg aagagaacta taaacatata ttgtgggaag
     3241 gaaaatttca gcagtggaac cagtttcagc agatcaaaag aagatgtgtc ttgggcatgg
     3301 aaccaaagtt acaatgaacc attcaactcc tgctgtgcag ggggggtcat tttaatgtaa
     3361 caccacaccc catggaaaca ctattcctga aaataaacat cattttaaaa aaaaacaaaa
     3421 caaacaaaag tgaaaaaaaa accaacttaa gggtgggcgg gtaatgaagc acgaggaata
     3481 atacctatga ggaactattt acaataaaat gtttcatttg aaaagtctgg tttcttacta
     3541 cagggatttg cttttctgtc tttatgattg ttttaaactc aggaacagag acatctatga
     3601 tgaggaggga agaaaaatac tctccatttt gtttctccaa aaggtggagt tggggatgag
     3661 aagtggattc tagttactct acaagcgcag agccaaggga ctctgaggag tttaacatgg
     3721 agtggaattg gaaatctatg cttcctcata tcacacacct gcatctctcc accatggatg
     3781 gactggtctc ctccgtactg aacaaggtga aaattatact cagaagtcac aaaccgccta
     3841 acttagctct gtcgaaaaca tcaagatcta tagggaacta gggccaggaa gcaactctgc
     3901 agcttccaga ttcaagttaa aattgcctgc agatgaatat gctgtctgac ttgtgtgaag
     3961 accccacaga aatgatgaga agctgacaac tgaacgtggg gttcccagag agctgcgcat
     4021 gttgagtatc ccagagcaat ctgaactctt gtcacttaga acaatagcat tattttctga
     4081 gatcgctgtc cgcaacaaga cgtctctact tttttataga caacactgac aagctggttc
     4141 tctatcacag gcagatagac aactaacact tttcctaagt cacatattac agagtattgg
     4201 tttcagcaat ggcagtaaat atatcctcct gaaaagctga ttttacacgt ccttgactgt
     4261 agataacaag gcaacctcaa tttctcaaat actcaatgtt ttctttccag gtttagaaat
     4321 cccatgcatc gagaatgtgt gtagggagcc aggaactctt tctatgaaat gctacacaaa
     4381 caggtccata tgtgaattga gtatattctc cttcagtttt aacactggca atttcaaagc
     4441 cagagcaact gaagaatctt caagacaaaa cagattcctg gggtcccaca tttttgtcct
     4501 tgtatttaat gctgacccaa ctgtttggcc cagtcactga acctctctgt gcctcagttt
     4561 cctcatctaa aaaaatgggg attaaatgtt ttgatttttt tcctaaggtt ttgtttgcaa
     4621 ttctggaaca agaggtgctt aaggtagcac aaagtgcttt gtaaccgtta taaatgctgt
     4681 attatttgac ttccctgtat aatgaaatag ttcctgagtt tgattcaaac agcagagcat
     4741 cactgaagcg tccccatcaa gctgcctagg acattattag caataaattg tgagattcaa
     4801 aaaccacaat attgaatcta taggaaatag attgactcgt tctattgaga aagacagaaa
     4861 gtgtgtcatt tcaatgctaa gcacctccca tgctctcctg attgcataac atgccatcaa
     4921 tcgaaacccc caacatcatc acaggagagc caaccatgca actacggatt gccaagaaca
     4981 gaaagcaaca aagaaagccg atattatttt tcaaagaatg tcagatgatg tgtcctaatg
     5041 caaaaacttt aaaagtcaga actgtactaa tggattcttt gtacaactaa ggtaagtccc
     5101 agatccccgc aattagcagg ttcattgtgc aggtgatgtg aaacagggta cttctcctac
     5161 accggccacc cagctaactc agtcctgtat gggagtacac aaacggcttg tttactgctt
     5221 caattatact tcacctacta ttataggacc cacttgagaa aatgcatact taatctgctc
     5281 cgtacatgcc ttcctcctct ccttttgctt ttcctatcga aaacctggtg ggtaaatttt
     5341 catatcagag aactatgtct aaattattat gaatgccaat aatatgctat atgttaccct
     5401 gttgttagtc aaattgcata aaacccatgc tgaactttct gagagcgaaa gccacttgag
     5461 taatcatctc tgaaactttg attggtggga gggggaggct ttctttctgt ttaatatcca
     5521 gaatatcact ctagatcgta agctaaatga tgacatcttt atcaggtgtt cgtcatagtc
     5581 ctcaaaatga gtgctctaat atttagacta ggaaagttta aatattttga tagagtccat
     5641 atctacgatg acagcatcaa gaaaaactgg aggtgtgcgt tttgcttatt cacagatgcc
     5701 tgagaatggt ttctatctta gtgaatgctt ccttgcatat gatgctcaga atagccaaaa
     5761 gaatgtacta ttagtaacaa agagttgtgc tgtgacatcg tttctcattt tcaaaagaaa
     5821 aaaaaggtaa ttcctactcc aggttttaaa ttttggtatc tgtacttagc tagagatttg
     5881 gggggatggg cacaataaga gtacacctaa ctactttttc ttagccatgt actcatctct
     5941 ctgaatccca ctgaagtagt ttgagaggtg aaagcttaac actgtcagga cttctcagat
     6001 ttccataaaa gaaatgcaca gactctatat gatatccatt ctacaaaaca aggtcagcaa
     6061 cttcagcatc ttgtcttaaa tgccatctaa cttatttcag ttgaaaaatt aaattagcac
     6121 tgtcagatcc tgtttgactt atgtcatatt cgctaaattg ctgctaaaag tgaggtttta
     6181 acaataaaag catactttgt tttgcttttt tttcccctac aattcagaat aagtttatat
     6241 caaagtataa aattcttccc aacgttcgag atgtgcatca tcactggggt cagaaagggc
     6301 cttcaattgc catagaagaa ataaaatttg ccaaatcatt tgtgctgtgg tattttattt
     6361 caaaccgttg gggtgttttt ttctacttga aataaatctc accaattttt cttctgctga
     6421 tttattgcta actttttcta aaaacacaca ataaaatctg tatgtttata acttaaatgg
     6481 aattgataag caccttcttt taaaacaatg cttatcattt taacttgcct gggttttcat
     6541 tgaaagctgt aaaaagagca tctgttggtt atgttgatat ttaaataact agaccatctc
     6601 tgcgatgtca catcagaata gatgaccagt gtactcagta ttaaagcata tagatgtgtt
     6661 ctttttattt gtcaaagaac ggaatggaat actccctctc cctccccctc tccctccccc
     6721 tctccctccc cctctccctc cccctctccc tccccctctc cctccccctc tccctccccc
     6781 tctccctccc cctctccctc cccctccccc tctccctccc cctccccccc ctctctctct
     6841 ctcacacaca cacacacaca tacaatatgt gtaccaagac aagatttgta agactcagct
     6901 atgttgattg gcagttgcat tgcttttgtg acgcttccac tgccctctct ccctcccccc
     6961 tccactcttc cctcctgctt tttgttttct tttttatact ggtgctatag gttgaatcca
     7021 ggtgcctggg cattctagac agcacacagc tgtatctccc cagaccccag ccctggtaat
     7081 ttaatatatt ttagggatta aatttgatct actatatgga aagtacataa atgtaacttt
     7141 tgaagtataa cttatgcaag tagctcttag atggctgtgc catggtgttc aggatggatg
     7201 caaagccccc tttctgctta gatggggaaa agacataaga taaagatttc cttattccca
     7261 actgctttat acttttcata tagaatatgc ctagagacta gattccatac ttatatacaa
     7321 gaggactttc aatgctggaa gaatggggtt gttcctcggg atgtcacttc agaactgagc
     7381 aaggcaggtt ttcttcccat ccctgatttt atcagttgag ttcctcctca ataaatcttt
     7441 attgctgaga gagcctgagt tgagttctta atttgacttt taaaagatac atgtaaaggg
     7501 gcagtacagg aaagtggact gaaattcacc acattcactc tagtgtgaca aacctgtaat
     7561 tgattcactg aagctttctg gttttatttt gctatttgat tttgtactga aatctttgtt
     7621 gtataaagtc ctacagggcg gcaatggtgc agacaaacaa tgttgagtcc cctttgccca
     7681 catgaagact ctacaaactt actaaagaat gaatgatcca atctctcaat cagaaacaga
     7741 tctggaacct gctataaact gcagtcactt aagtttgaca gacacctcac aaaacgtgcc
     7801 tatttcccct cttaactaaa ccatctctcc tgaataaggc aaatcaaaat ctaaacactt
     7861 aataaataca agatgtacat agtcatgcat atgtatcctg tacagagtat ggtggtgcag
     7921 gcattaacag atatgtactt cagacctcga cagaagactt agagatgatg cttttctgat
     7981 gtcactaggc aactcgattt tgtttggcgt atagtgtcta tacccacccc tccttggcta
     8041 tatctctacc ttccaccatt actgctattt cctgttgcct gtgaattttc cacgaccctg
     8101 tcctctaagc agaacgtttt gttccctagc atctcaataa aacgcccagc acaatttaca
     8161 gtattaatat caatcaaagg tcctatgctt ttctcaacta aaattgcatt tccagaagct
     8221 tctgtgcatg atctaaccta tagtatttaa ttctgtgagg atttgagttt acagggaaca
     8281 tatttgaatc cacaattcct tgtgtatcta ttgagttagt gtagccaggg ggctggtttc
     8341 caaagcattc ctacgattgc ctgcattagt tcaggtcctt cctatcacag catgactagt
     8401 aggccacttc agtgcttact gatgagaggc agaacttgat tgaatgcagc agagggattg
     8461 tctgaggttc acgggacagg tacatgtgct gtatgtatca ccatagagat cggaatccat
     8521 ttattgtatg taaagtttta tgaacggtta ttttataatt tatgtattta atatagcaat
     8581 caatgaactc tggtgtttta gtttctatga aaaataaaac aaactgcatt ttttaaaaaa
     8641 aataaaagct tttaccttgt gttattcata a
//
LOCUS       NM_001437238            3707 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 5, mRNA.
ACCESSION   NM_001437238 XM_063271160
VERSION     NM_001437238.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3707)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271160.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.84525.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000012.1  32093206-32093268   c
            64-128              JAXUCZ010000012.1  32090917-32090981   c
            129-298             JAXUCZ010000012.1  32090465-32090634   c
            299-393             JAXUCZ010000012.1  32090152-32090246   c
            394-571             JAXUCZ010000012.1  32079959-32080136   c
            572-857             JAXUCZ010000012.1  32077686-32077971   c
            858-1008            JAXUCZ010000012.1  32072686-32072836   c
            1009-1192           JAXUCZ010000012.1  32071923-32072106   c
            1193-1336           JAXUCZ010000012.1  32070118-32070261   c
            1337-3707           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3707
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..63
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            64..128
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            129..298
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            299..393
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    383..385
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            394..571
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1357
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001424167.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    440..1183
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    440..1183
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    473..535
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    644..730
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    947..1009
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1220..1282
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            572..857
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1008
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1192
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1336
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..3707
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatgatca cccactgccg gtgtggacac atcacatgct gtggttctca gtgatcacat
       61 aacagcgcta ggattaaagg catgcaaggc ggaagatacc aggatctcca aggaaattgc
      121 agataaagct ccacaggtgt ccatggtgac ctcacgcagc tttctggcag ttctgattgg
      181 ggaatcgtac caacctgcct gtttataaga aggacctgac acaggacacc acccagagag
      241 ggaatcaggg tgcgacggac agacaaagca tttgaatttg gagcgtaaag aacctccacc
      301 acatctgtga aggaaactca tgtctaagag caccccgacc tttgacactc taaggacagg
      361 tggatgtgat ctttaccaca gatgaccctt tcggttgccg ctggtgagaa gcatgttcag
      421 cattaacccc ttggagaacc tgaagctgta catcagcagc cggccaccgt tggtggtttt
      481 tatgatcagt gtcagcgcca tggccatcgc cttcctcacc ctgggctact tcttcaagat
      541 caaggagatt aagtccccag aaatggctga ggattggaat actttcctgc tccggtttaa
      601 tgatttggac ttgtgtgtat cagaaaatga gacactgaag catctctcca acgataccac
      661 cacacctgag agcaccatga ccatcgggca aaccagatcg tccacccagc cgccccagtc
      721 cctggaggag tcaggcccca tcaatatttc agtggccatt accttgacct tggaccctct
      781 caagcccttt ggagggtact ctcgaaatgt cacacacctg tactccacca tccttggcca
      841 tcagattgga ttgtcaggca gggaagccca tgaggagatc aacatcacct tcaccctgcc
      901 tgctgcctgg aatgccgatg actgtgctct ccatggccac tgtgagcagg tggtgttcac
      961 agcatgcatg accctcacag ctgcccctgg agtcttccct gtcaccgttc agccacctca
     1021 ctgtgtcccc gacacataca gcaacgccac actctggtac aagatcttca caactgccag
     1081 agatgccaac acgaaatacg ctcaagacta caaccctttc tggtgttaca agggcgccat
     1141 tgggaaagtc taccacgctt taaatcccaa gctcaccgtc attgtcccag atgacgaccg
     1201 ctccttaata aacctgcatc tcatgcacac cagttacttc cttttcgtga tggtgataac
     1261 gatgttctgc tatgcagtta tcaaaggcag acccagcaaa ctgcggcaga gcaatcctga
     1321 attttgccct gagaaggtgg ctttggctga tgcctaatcc cacagctccc cattttctga
     1381 gagaccaaga accatgatca ttgcctgctg aatcggccag ggcctggcca ctctgtgaat
     1441 acacgatctt gcaatgttgg gttattccag ccaaagacat ttcaagtgcc tgtaactgat
     1501 ctgtacatat ttataaacgt tgatctggaa actggtcctg tggtgcacgt gctttgccct
     1561 ggatgcggcc ggaacccgtc agcctcactg aggggcagga gggcactgac atggggttct
     1621 tccatgaagt gccgggggat gtgggaatct tgccagagct gagcgtgtcg tgttccaaca
     1681 ccagcggccg aggttggctg cggttcttgt ctcagacggg ggtgtgcagt gttggacgct
     1741 gtgtgcacct ttgtcaggac actgtttcag aagccaccat tccctcctgc ggctctcacg
     1801 tgtctcagtg accatatagc gacagcagta gttccttctc agtttgcttg caaggaaact
     1861 gtttttaaaa gagaaaacaa gctacatttt atattcccct tgttaggaca gacaggcttg
     1921 tctatccagg tcaaaggtca cgcccccaag gcatttctgt agtgaagagc agagttccgt
     1981 ctccacactg gcccctagga actggagtgc tttgctcctc tgtgctcctg gtagagaagt
     2041 tcctggcttg agaagtggcg gtgtaatggg gacacagggc agcacaggct gcctaacttc
     2101 acaaggcaga agagatggcg ggctgctgta atgctcacaa gcagggcttg cttttttttt
     2161 ctttctaaaa ttcgtttcgc attcattttt gtacatcaca catctatctc cagaaggaga
     2221 atgaacatta taggtatata atgtggagct ggtgcaggga agatctgaag gaagaaggcg
     2281 tatgaggcgc tgatggctgg ccagtcaaaa ccagaagcgt tttccttagg acagttgtga
     2341 ccatccggcc ccagtgccct ctcgcatttc ctttaggaaa gtcattcgca ttcccttctg
     2401 cgagttactt gtatttgcag tggttttcta tcaatgcctt gccttaatgc ccatgcagtg
     2461 ttcttccagg cagtgttcca gacttgctgg gtgtgaggat gaatgcatgt taggagcagc
     2521 cctctggagg ccgagggagg agaatctcga gtgcgaggct ggcctgggcc acatactgat
     2581 agcctgtctc acaggaagaa aaactactta ggtatgtcag cacttctgtc ccgtaactgt
     2641 aggtctgtct cagttgcagt taacttgctg tatcccgaac cttactggcc tagagaattt
     2701 tatcccaggc attcttagat ggaaaacaat actttggatt tttgttctaa attgaagctt
     2761 gtgaaaataa tcactgtagt taggtgacgc cctaatgttt tttaaagcag aggtgagtta
     2821 cttataagat ggctaatgtg tgaatttcat ttagtcttcc cttagacttt gagagccttg
     2881 tcaggcagga tggagaaaac ccacgtggct tagctggtat gaatgtgtca tcaggaccat
     2941 caagtttcag attaagtagt aagacccagt agagtaagac atgagaagaa atcaccttca
     3001 ttggtctgtc ggctgtgttc ctcttagtca tccttgtgtt aatgacaggc agtggctggg
     3061 atttgtagag ggtgggaagg aggaacacca taagacctgg ggagaggaag tccccaaaat
     3121 gcttgagagt gacccatcct gaggccagat acatatttta aagcccaagt attcgccata
     3181 gcaggtagac agatggagga tggctgggga aggaggttgt gggctgagtt taggggactg
     3241 cagacacatc tgggcctggt cctcagctgc tccttggtgg taaacctcaa aaatggcatg
     3301 tcagattggc cactagagac ctctgacccc agcagcactg gcttgtcctc aggtgtgggt
     3361 gtgtcagaag tcagtgactt cctgggaaat ggttgtttcg gatcacattg atctttcctt
     3421 ttgtctttca ccgtatggta ggacttgaat cagttttgat tctgtgtgta cgttctcttc
     3481 gtttggaacc tggcgtttct gtctgttctt ggcagtgcat aggaacccag cctcctgtat
     3541 tttgaccctc ctgcaggcac tgtgggaccc aagggtagca gatccatctc ccgtcccttg
     3601 ctgcatgatg gtcactagct gatctgtgat ggcatccctc cctcattgat tttctgtgtt
     3661 tgaagtatgt gcacatgtgc tttacagaat aaaacatctg gatttac
//
LOCUS       NM_001437298             711 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437298
VERSION     NM_001437298.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 711)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.947200.1,
                                           SRR26360190.1534691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000011.1  44781238-44781317
            81-220              JAXUCZ010000011.1  44823304-44823443
            221-711             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..711
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..80
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            81..220
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..413
                     /gene="Mrps6"
                     /note="isoform 4 is encoded by transcript variant 5; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 4"
                     /protein_id="NP_001424227.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGYFLVDFYAPTN
                     AVESMLEHLARDTDVVRPNIVKHPLTQEVKECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    <123..323
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    <123..323
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(168..170,174..182,222..224,228..230,303..305,
                     315..317)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(168..170,174..182,222..224,228..230,303..305,
                     315..317)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(180..182,192..194,249..251,258..263,282..284,
                     303..305,312..320)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(180..182,192..194,249..251,258..263,282..284,
                     303..305,312..320)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     exon            221..711
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggagagg gaggaggcct ggaaagttcc actggtttct agagcccaag gttggtcggc
       61 gcggaggcgg cgcgcagcgg ccagagaccg ctgctgcttt aaaacgtaca atagaatccc
      121 tgatggaccg aggagccata gtgaggaact tggaaaacct gggtgagcgt gcactcccat
      181 acaggatctc cagtcacagc cagcagcaca gccgaggagg gtatttcttg gtggattttt
      241 atgccccaac aaatgctgtg gaaagcatgc tggaacactt ggcacgagac actgatgtgg
      301 ttagaccaaa tattgtgaaa caccctctga cccaggaagt aaaagagtgt gacggcatag
      361 tcccagtccc tcttgaagaa aaactgtatt caacaaagag aaggaagaag tgagaagatt
      421 caccagatgt ggctatgttc aattctaagt gcaccatggg tgctgatagg tttgtctagg
      481 atgctttagc ccgtgaccat tttgctgcag atggggactg ctggccgaga cctgctctgt
      541 cacccctgct gatatttcac cctcactgtg tgattgtcag ggtgcggtgg ggctggtgtt
      601 cacagtccca ctgcagagtt tcgaagaaca aaatgtttgt cattcacact cggttgtctt
      661 gtaaacctgt gtggaacaca gagcagagta ataaacatgg ttttatcaac a
//
LOCUS       NM_001402454            1576 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 9 open reading frame
            153 (C17h9orf153), transcript variant 3, mRNA.
ACCESSION   NM_001402454 XM_017600682
VERSION     NM_001402454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001402454.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.204017.1,
                                           SRR26360181.2702757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000017.1  4980936-4981000
            66-248              JAXUCZ010000017.1  4981452-4981634
            249-344             JAXUCZ010000017.1  4985033-4985128
            345-834             JAXUCZ010000017.1  4986300-4986789
            835-1576            JAXUCZ010000017.1  4987547-4988288
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1576
                     /gene="C17h9orf153"
                     /note="similar to human chromosome 9 open reading frame
                     153"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
     exon            1..65
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            66..248
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    210..212
                     /gene="C17h9orf153"
                     /note="upstream in-frame stop codon"
     exon            249..344
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1082
                     /gene="C17h9orf153"
                     /note="isoform 1 is encoded by transcript variant 3;
                     uncharacterized protein C9orf153 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153 homolog isoform
                     1"
                     /protein_id="NP_001389383.1"
                     /db_xref="GeneID:100912252"
                     /db_xref="RGD:6488044"
                     /translation="MSSTRHHTWTRGSIGSLYLHRCSLPELYASLEIFNKESKKSNLQ
                     KICGMSFKEAQEVLWKILGGLISDSYDTVKGDERHPSIPVNKEERKTPSMSDLLHQSL
                     LKGYNVPLEQVHSSQQRLAQVGIPPPPLSFPHGLSNELPVILPAQHFRKRIQSVTFRK
                     LLLSSVAPGRLFYEEKPTSQQVSFDPGKQFLDLADLQWRYFKGLAKWGKMPRRFSLLN
                     IEYNSEKRYVENQRMSGLIFPPLVRKTLMVYPQAEYDKEGQLYLTWKIVY"
     misc_feature    276..551
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     misc_feature    276..551
                     /gene="C17h9orf153"
                     /note="Family of unknown function (DUF5532); Region:
                     DUF5532; pfam17673"
                     /db_xref="CDD:465450"
     exon            345..834
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1576
                     /gene="C17h9orf153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgagcct gcggtctacc aggtgaagga tactcagcct gggacttcag agattaccca
       61 caaagagcta gtgctcatga gaaagctacc tcctttgaac catgatggaa tatgatttgt
      121 gaacaatgaa aagatgtgta aggtcaaact gggttccaac ctacgctgct gggatgaact
      181 ctccctgcca cagcgggcct ggcaatcctt aaggacacca cccatccaac caagacgtcc
      241 ctaagcagga acgtggaggt tcagatcttg gcacaatgtc ctccaccaga caccacactt
      301 ggacccgagg cagcatagga tccctgtatc tgcaccgttg ttcgctacca gaattatatg
      361 catcacttga gatttttaat aaggagagca agaaatctaa tctccaaaag atctgtggca
      421 tgtcgtttaa ggaagctcag gaagtccttt ggaaaatcct gggtggcctg atctctgaca
      481 gctatgacac cgtaaaaggg gatgagcgcc acccttccat accggttaac aaagaggagc
      541 ggaagacacc atctatgtca gatctacttc accaaagtct gttaaagggt tacaatgttc
      601 cgttggagca ggtacacagc tcccagcaga ggctggccca ggtgggcatc cctcctcctc
      661 cactctcctt tcctcacggt ttaagcaacg aactgcccgt gatccttcca gcacagcact
      721 tcaggaaaag gattcaaagc gtcacattcc gcaaacttct cctgtcttct gttgccccag
      781 gcaggctgtt ctatgaagaa aagccaacaa gccaacaagt ctcctttgac ccaggaaagc
      841 agttcctaga cctggcagac cttcagtgga ggtatttcaa gggacttgca aagtggggga
      901 aaatgcccag gaggttttcc ctcttgaaca tagaatacaa cagtgagaag agatacgtag
      961 agaaccaacg tatgtctgga ctcatcttcc ctcccctagt tcgcaagact ctgatggtct
     1021 accctcaagc tgagtatgat aaagaaggac agctttatct cacctggaaa atagtgtact
     1081 gaaatagtct ggatatgaac cgttctgctt gggattgccg aaccaacaca agaggtggaa
     1141 aagcacacag cccacttctc tactcaatgt ccgtgcaaag cctacattaa aatgatttcg
     1201 tggaggaaca tgtccaacca atctgctggc attactctgg ttcacagttc tgatgctcat
     1261 ctgaacagca ggtgaaggga atactgggtg gatacacaga aatagctctc caccaaaaat
     1321 ggatctctac aatgttttct tccttggttt ctctgtttct ttgtttctgg tttgtttatt
     1381 tgtttgtttg tttgtttact ttttgctgtc aatatgtaat ttacttactt aaaaaaatcc
     1441 aaattctggc attgtctaga aaatttcagt aggttttaaa gttgaactgt tgaaatgtgt
     1501 tcacggaagc attctgcttg cattaatgct ttacacggtg catgtatatt aaaagtcaca
     1561 cccaaatgaa cgtgga
//
LOCUS       NM_001437235            3702 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 2, mRNA.
ACCESSION   NM_001437235 XM_063271163
VERSION     NM_001437235.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271163.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.2536092.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000012.1  32087200-32087430   c
            232-388             JAXUCZ010000012.1  32086708-32086864   c
            389-566             JAXUCZ010000012.1  32079959-32080136   c
            567-852             JAXUCZ010000012.1  32077686-32077971   c
            853-1003            JAXUCZ010000012.1  32072686-32072836   c
            1004-1187           JAXUCZ010000012.1  32071923-32072106   c
            1188-1331           JAXUCZ010000012.1  32070118-32070261   c
            1332-3702           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3702
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..231
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            232..388
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            389..566
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1352
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001424164.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    435..1178
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    435..1178
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    468..530
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    639..725
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    942..1004
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1215..1277
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            567..852
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1003
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1187
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1331
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..3702
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtggttt tctgctttca cccggaaagc ccggcgttcg cagcgcggag ccggcgtccc
       61 gttggcgcgc tctggcctgt cttcaggttg tcgctttcgc cccgaggagc tgctcgctgt
      121 ctccggagcg gcggagagga tggtgcgggg cagtccgggg cccgccgcgc gccgccgcga
      181 gtgaacaggg ccaggccgcg ggcgcccgcg gagccgcggg tctgtggggc gatacccacc
      241 gactccagaa gagggcgttg tattcctgga accagagtta cacgccattg ttagctgcct
      301 gatgatgtgg gtgctgagaa cctaactctg gtcttcggga atagcaggtg ttgttcttaa
      361 cgcccgtggc catctctcca acctccacgt tgccgctggt gagaagcatg ttcagcatta
      421 accccttgga gaacctgaag ctgtacatca gcagccggcc accgttggtg gtttttatga
      481 tcagtgtcag cgccatggcc atcgccttcc tcaccctggg ctacttcttc aagatcaagg
      541 agattaagtc cccagaaatg gctgaggatt ggaatacttt cctgctccgg tttaatgatt
      601 tggacttgtg tgtatcagaa aatgagacac tgaagcatct ctccaacgat accaccacac
      661 ctgagagcac catgaccatc gggcaaacca gatcgtccac ccagccgccc cagtccctgg
      721 aggagtcagg ccccatcaat atttcagtgg ccattacctt gaccttggac cctctcaagc
      781 cctttggagg gtactctcga aatgtcacac acctgtactc caccatcctt ggccatcaga
      841 ttggattgtc aggcagggaa gcccatgagg agatcaacat caccttcacc ctgcctgctg
      901 cctggaatgc cgatgactgt gctctccatg gccactgtga gcaggtggtg ttcacagcat
      961 gcatgaccct cacagctgcc cctggagtct tccctgtcac cgttcagcca cctcactgtg
     1021 tccccgacac atacagcaac gccacactct ggtacaagat cttcacaact gccagagatg
     1081 ccaacacgaa atacgctcaa gactacaacc ctttctggtg ttacaagggc gccattggga
     1141 aagtctacca cgctttaaat cccaagctca ccgtcattgt cccagatgac gaccgctcct
     1201 taataaacct gcatctcatg cacaccagtt acttcctttt cgtgatggtg ataacgatgt
     1261 tctgctatgc agttatcaaa ggcagaccca gcaaactgcg gcagagcaat cctgaatttt
     1321 gccctgagaa ggtggctttg gctgatgcct aatcccacag ctccccattt tctgagagac
     1381 caagaaccat gatcattgcc tgctgaatcg gccagggcct ggccactctg tgaatacacg
     1441 atcttgcaat gttgggttat tccagccaaa gacatttcaa gtgcctgtaa ctgatctgta
     1501 catatttata aacgttgatc tggaaactgg tcctgtggtg cacgtgcttt gccctggatg
     1561 cggccggaac ccgtcagcct cactgagggg caggagggca ctgacatggg gttcttccat
     1621 gaagtgccgg gggatgtggg aatcttgcca gagctgagcg tgtcgtgttc caacaccagc
     1681 ggccgaggtt ggctgcggtt cttgtctcag acgggggtgt gcagtgttgg acgctgtgtg
     1741 cacctttgtc aggacactgt ttcagaagcc accattccct cctgcggctc tcacgtgtct
     1801 cagtgaccat atagcgacag cagtagttcc ttctcagttt gcttgcaagg aaactgtttt
     1861 taaaagagaa aacaagctac attttatatt ccccttgtta ggacagacag gcttgtctat
     1921 ccaggtcaaa ggtcacgccc ccaaggcatt tctgtagtga agagcagagt tccgtctcca
     1981 cactggcccc taggaactgg agtgctttgc tcctctgtgc tcctggtaga gaagttcctg
     2041 gcttgagaag tggcggtgta atggggacac agggcagcac aggctgccta acttcacaag
     2101 gcagaagaga tggcgggctg ctgtaatgct cacaagcagg gcttgctttt tttttctttc
     2161 taaaattcgt ttcgcattca tttttgtaca tcacacatct atctccagaa ggagaatgaa
     2221 cattataggt atataatgtg gagctggtgc agggaagatc tgaaggaaga aggcgtatga
     2281 ggcgctgatg gctggccagt caaaaccaga agcgttttcc ttaggacagt tgtgaccatc
     2341 cggccccagt gccctctcgc atttccttta ggaaagtcat tcgcattccc ttctgcgagt
     2401 tacttgtatt tgcagtggtt ttctatcaat gccttgcctt aatgcccatg cagtgttctt
     2461 ccaggcagtg ttccagactt gctgggtgtg aggatgaatg catgttagga gcagccctct
     2521 ggaggccgag ggaggagaat ctcgagtgcg aggctggcct gggccacata ctgatagcct
     2581 gtctcacagg aagaaaaact acttaggtat gtcagcactt ctgtcccgta actgtaggtc
     2641 tgtctcagtt gcagttaact tgctgtatcc cgaaccttac tggcctagag aattttatcc
     2701 caggcattct tagatggaaa acaatacttt ggatttttgt tctaaattga agcttgtgaa
     2761 aataatcact gtagttaggt gacgccctaa tgttttttaa agcagaggtg agttacttat
     2821 aagatggcta atgtgtgaat ttcatttagt cttcccttag actttgagag ccttgtcagg
     2881 caggatggag aaaacccacg tggcttagct ggtatgaatg tgtcatcagg accatcaagt
     2941 ttcagattaa gtagtaagac ccagtagagt aagacatgag aagaaatcac cttcattggt
     3001 ctgtcggctg tgttcctctt agtcatcctt gtgttaatga caggcagtgg ctgggatttg
     3061 tagagggtgg gaaggaggaa caccataaga cctggggaga ggaagtcccc aaaatgcttg
     3121 agagtgaccc atcctgaggc cagatacata ttttaaagcc caagtattcg ccatagcagg
     3181 tagacagatg gaggatggct ggggaaggag gttgtgggct gagtttaggg gactgcagac
     3241 acatctgggc ctggtcctca gctgctcctt ggtggtaaac ctcaaaaatg gcatgtcaga
     3301 ttggccacta gagacctctg accccagcag cactggcttg tcctcaggtg tgggtgtgtc
     3361 agaagtcagt gacttcctgg gaaatggttg tttcggatca cattgatctt tccttttgtc
     3421 tttcaccgta tggtaggact tgaatcagtt ttgattctgt gtgtacgttc tcttcgtttg
     3481 gaacctggcg tttctgtctg ttcttggcag tgcataggaa cccagcctcc tgtattttga
     3541 ccctcctgca ggcactgtgg gacccaaggg tagcagatcc atctcccgtc ccttgctgca
     3601 tgatggtcac tagctgatct gtgatggcat ccctccctca ttgattttct gtgtttgaag
     3661 tatgtgcaca tgtgctttac agaataaaac atctggattt ac
//
LOCUS       NM_001437379             822 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 3, mRNA.
ACCESSION   NM_001437379 XM_039094841
VERSION     NM_001437379.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039094841.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.2154549.1,
                                           SRR26360172.2439696.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000016.1  82528885-82529051   c
            168-248             JAXUCZ010000016.1  82512490-82512570   c
            249-313             JAXUCZ010000016.1  82511368-82511432   c
            314-483             JAXUCZ010000016.1  82508838-82509007   c
            484-822             JAXUCZ010000016.1  82504646-82504984   c
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..822
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..167
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             78..551
                     /gene="Cfap97d2"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 3"
                     /protein_id="NP_001424308.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKRVASAMKTGRRIDGQNNFTWRSLNRKSREQALMKVQKQNQAVPER
                     LRSSEPWYGAQRWREDWTAMATRPCTCRHTWRKGADREAQQGHSLIWMRSLKRKG"
     misc_feature    159..389
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    159..389
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            168..248
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..313
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..483
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..822
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcaaac agctctgcgg gggctgtact gctgtgcctg ctcttccctg aagggaccct
       61 ggagtttgtg atctgagatg catagagtgc cccagctgac caccccgtgg gctagtagag
      121 acctgcagag agcctgggag aaaacctacc agaaccacag gaaaaaggtc cagaacgccc
      181 aaccactcgt ggacacccgc ccaccacaga cttacagcca cctccaccta aagttcaaga
      241 agttgaagag ggtggcctcc gccatgaaaa ccgggagacg gattgatggg caaaataact
      301 tcacatggag aagtctaaac aggaaatcga gagaacaggc attgatgaaa gtgcagaaac
      361 aaaatcaagc cgttccagaa agactcagaa gctcagagcc ctggtatgga gcacagagat
      421 ggcgggagga ctggactgcc atggccacgc gtccctgcac atgcagacac acctggagaa
      481 aaggagctga tcgtgaagcc caacaaggcc acagcctcat ctggatgcgc agcctgaagc
      541 ggaaggggtg agggttcacg acccaaccac cgaaagaaga ccagggcctg gaagctccga
      601 tgaggccttc ctgtgtctcc caggggtggg ggtggggatg tggggtgtgc aggtctagca
      661 tccgagatca cgctggctct ggggacggct gtgggagctg tgacgcggca ctctgaagct
      721 tcacggtcac ggccgtcgcc agatgacaca gcacggctgt ttactgtgtt tcttggaccg
      781 ataaccaaaa acaaaatatg cagagtgact ctgcgagtta ca
//
LOCUS       NM_001105923            1191 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17),
            transcript variant 4, mRNA.
ACCESSION   NM_001105923 XM_001078418 XM_213762
VERSION     NM_001105923.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001105923.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.4039202.1,
                                           SRR26360176.1497545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               JAXUCZ010000012.1  32587461-32587880   c
            421-560             JAXUCZ010000012.1  32586490-32586629   c
            561-1191            JAXUCZ010000012.1  32584816-32585446   c
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1191
                     /gene="Mrps17"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
     exon            1..420
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    408..410
                     /gene="Mrps17"
                     /note="upstream in-frame stop codon"
     exon            421..560
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..821
                     /gene="Mrps17"
                     /note="28S ribosomal protein S17, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_001099393.1"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
                     /translation="MSIVRSAVHAKWVVGKVIGTAMVKTAKVRATRLVLDPYLLKYFN
                     KRKTYFAHDALQQCSVGDIVLLRALPVPRAKHVKHELAEIIFKVGRVIDPVTGKPCAG
                     TAYLESPLSSEATPPCESREELKSS"
     misc_feature    468..689
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     misc_feature    468..689
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     exon            561..1191
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgcc caggctcctc cggccttggt ccgagttgta ggttttggag gtgagcgagg
       61 gctacggatc tgggtattgg gttcggcagt gctacgtctc ctgttactct ccctggtggt
      121 ttcggtagca aatgattccc aaagcggctc cgagtcaaag tctcgttgtt cctgtacagg
      181 aagctggctg accggccgag gtcttgcagt gagctcttgt gtgtgtggta gcgggctgta
      241 ttgtctataa ttgagacaga gaactgcaat aaatgctgtg acctcgagaa cgtgccctgc
      301 taacgacaag aaataaacct cgcagactcg ggagttgagc gcttcaaaca gcatcgttta
      361 ttataatact ccctaattgg gaaccagttc caagaaagga caccaagtga cacggacgag
      421 gcgctcacag acacataatg tcaatagtcc gttcagccgt ccacgccaaa tgggttgtgg
      481 ggaaggtgat tggtacagca atggtaaaaa ctgctaaagt aagagcgacc agacttgttt
      541 tggatcccta cttactaaag tactttaata agcggaaaac ctactttgct catgacgccc
      601 ttcagcagtg cagcgtcggg gacatcgtgc tcctcagagc tctgcccgtc ccacgagcaa
      661 agcacgtgaa acacgaactg gcagagatca tcttcaaagt gggccgagtt atcgaccccg
      721 tcacaggaaa gccctgtgca ggaaccgcct acctggagag ccccctcagt tcagaagcca
      781 ctcccccctg cgaatctcga gaagagctca agtcctcctg aacctgggga agagggagcc
      841 agaggatgga tgtctgtctg tttgctcagt ggcttttcat actgtttctc ctgtgacatt
      901 agaagtattc aacagagtaa agagcttagc gttccataaa ggttcgcatc ctttttcaga
      961 ttctctgccc tgaagttacc ttccgagtac tctgtatgcc taagcgtgct gcgtcattcc
     1021 gtaagctcac tgtcctagat catatatgta ttgttttgtt tgccatcact caaagaaatc
     1081 ttggactttg cacctttatt ttaaaagaag aaaacctttt gataataaca gaaaaggcta
     1141 aacttagttt cgatagctga atttttcaaa atatatcgtg tgtgtccaca a
//
LOCUS       NM_001437344            2655 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus centrosomal protein 120 (Cep120), transcript
            variant 5, mRNA.
ACCESSION   NM_001437344 XM_063277304
VERSION     NM_001437344.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2655)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 2655)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2655)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 2655)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   5  (bases 1 to 2655)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277304.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.352627.1,
                                           SRR26643293.77410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000018.1  49388146-49388277   c
            133-198             JAXUCZ010000018.1  49387941-49388006   c
            199-355             JAXUCZ010000018.1  49383840-49383996   c
            356-470             JAXUCZ010000018.1  49382222-49382336   c
            471-612             JAXUCZ010000018.1  49379306-49379447   c
            613-761             JAXUCZ010000018.1  49375066-49375214   c
            762-959             JAXUCZ010000018.1  49373255-49373452   c
            960-1187            JAXUCZ010000018.1  49370600-49370827   c
            1188-1404           JAXUCZ010000018.1  49369293-49369509   c
            1405-1582           JAXUCZ010000018.1  49367897-49368074   c
            1583-1732           JAXUCZ010000018.1  49365316-49365465   c
            1733-1915           JAXUCZ010000018.1  49364545-49364727   c
            1916-2012           JAXUCZ010000018.1  49361228-49361324   c
            2013-2171           JAXUCZ010000018.1  49360986-49361144   c
            2172-2655           JAXUCZ010000018.1  49360408-49360891   c
FEATURES             Location/Qualifiers
     source          1..2655
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2655
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
     exon            1..132
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="upstream in-frame stop codon"
     exon            133..198
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2213
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="isoform 3 is encoded by transcript variant 5;
                     centrosomal protein 120kDa; coiled-coil domain containing
                     100; centrosomal protein of 120 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 3"
                     /protein_id="NP_001424273.1"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
                     /translation="MVPKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPV
                     DHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTA
                     QETKQAPKWYQLLSNKYTKFKSEVQISITLETDTKAQVDSFKAKGAPPRDGKVPASLL
                     GVDPKDIVAVLNEEGGYHQIGPAECCTDSFTLSVTIAFATQLEQLIPCTMKLPERQPE
                     FFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEVLRVYLALHSKLQIHLCCG
                     DQSLGSTEIPLSGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPVELAPTVGV
                     SVALQREGIGSQSLIELKTQNGHEPEHSQKRVLTPIKEKTLTGPKSPRVSPAPPQNQT
                     PPTKDDATESEVESLQYDKEPKQVVKGTGSIPASLAQPEATGNPSEVVTSGQKIAVPA
                     TSHHFCFSIDLRSIHGLEISFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQ
                     SYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFL
                     GANGEQCWRQTYSEKVPVIAAQGSNNRIVDLSYTMTLEDYGLVKMREIFVSESSQGMS
                     AVGQRASPPPPPPAPCPSEIQVEPRETLEYKAALELEMWKEMQEDIFESQFLRLSTMF
                     LRFIV"
     misc_feature    174..491
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    174..491
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    501..1169
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    501..1169
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     exon            199..355
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            356..470
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            471..612
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            613..761
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            762..959
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1187
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1404
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1582
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1732
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1915
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2012
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2171
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2655
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgccct ttgtcctcca acctcccccg ggctctcggc ccgcgggcct ggttgctagg
       61 cggaagcggg gcgcggcggc gtccgctgcg gctgcccggg cgtttgaata gcggcttagc
      121 aggcggcaaa agaccccgcc gccacgacca tggtccccaa gtccgaccag ctgctcatcg
      181 tcgtatccat cctcgaaggt cgccatttcc ccaaacgtcc aaagcatatg cttgtggtgg
      241 aagcaaagtt tgatggggag cagttggcca ctgatcctgt cgaccatact gaccagccag
      301 aatttgctac tgagttagcc tgggagatcg acaggaaagt ccttcatcag cacaggttac
      361 agcgcactcc catcaaactg cagtgctttg ccttggatcc tcagacttct gccaaggaaa
      421 ccgtaggcta cattgttttg gatttaagaa cagctcaaga aacaaagcag gcacccaaat
      481 ggtaccagtt gctgagtaac aaatacacca aattcaagtc cgaggtacag ataagcatca
      541 ctttggaaac agatacaaag gcacaggtgg atagttttaa agcaaaagga gccccacctc
      601 gggatggaaa agttcctgct agcctgttag gagttgaccc taaggacatc gtggcagtgt
      661 tgaatgagga gggaggctac catcagattg gaccagcaga gtgttgtact gactccttta
      721 ctctctcagt gaccatagca tttgccaccc agttggaaca gttaattcca tgtaccatga
      781 agcttccaga aaggcagcct gagtttttct tttactattc tttattggga aatgatgtta
      841 caaatgagcc gtttagtgat ttgatcaacc cgaactttga gccggagagg gcgtctgtcc
      901 gcatacgaag cagcgtggag gtccttcgtg tgtacctggc tcttcactcg aaactgcaga
      961 tccatctctg ctgtggagac cagtcactcg gcagtacaga aatacctcta agtggattac
     1021 tgaagaaggg cagcacagag attaaccagc atccagtcac agtcgagggt gcgtttaccc
     1081 ttgaccctcc aaaccgagcc aagcagaagc tcgctcctgt tcctgtcgag ctggccccaa
     1141 ctgtgggagt gtcagtggct ctgcagagag aaggcatcgg ctcccagtct ttaattgaat
     1201 taaagaccca gaatggacat gagcctgagc actcacagaa gagagtttta acccccataa
     1261 aggagaagac actcactggg ccaaaatcac caagggtgtc ccctgcccca cctcaaaacc
     1321 agacacctcc aaccaaggac gatgccacag aaagtgaagt ggagagcctg cagtacgata
     1381 aggagccgaa gcaggtggtg aagggcactg gttccatacc tgcttcgctg gcccagccag
     1441 aggcgactgg caacccatca gaagtggtga catcggggca gaagattgct gttccagcaa
     1501 catcacacca cttctgcttt tcaatagact tgagaagcat ccatggcttg gaaattagtt
     1561 ttccagtcaa ctgcatattg aggtactcct acccattctt cggcagtgca gctcctatta
     1621 tgactaaccc tcctgtagaa gttcggaaga acatggaagt ttttcttcct cagtcttact
     1681 gtgcatttga ttttgcaact atgcctcacc agctacaaga caccttccta aggattccac
     1741 tgcttgtaga actatggcac aaggataaaa tgagtaaaga cttactcctt gggattgcaa
     1801 gaattcagct ttctaacatc ttgtcttcag aaaagacccg gtttctaggt gctaatggtg
     1861 aacagtgctg gcgacagact tacagtgaga aagtgcctgt catagcggcc caggggtcaa
     1921 ataacaggat agtagacctt tcttacacaa tgactctgga ggactatggc ctggtgaaaa
     1981 tgcgtgagat ctttgtatct gagtcatctc agggcatgtc tgctgtgggt cagagggcgt
     2041 ctcctcctcc tcctcctcca gctccttgcc cttctgagat ccaggtggag ccccgggaga
     2101 ccttagagta caaggctgca ctggagctgg agatgtggaa agagatgcag gaggacatat
     2161 ttgaaagtca gtttctgaga ctgtcaacaa tgtttttgag atttatcgtt tagttatgtg
     2221 aatgcatgtg tgttggtgtg ggtatgtgca cacaagtgtg gagctgccat gaatctgaga
     2281 agagcactgg atccctggag gctgcacttg tggtcctgag atgtctgatg tggctgctgg
     2341 gagccaaagt tgagactgct ataagagctc ttaatggcga acccctctcc atccccacag
     2401 agccttcctc aaagaaaaac ataagaatac tcgagatata gtagtctcat agctactact
     2461 cagaaagatt tccctgaatt tgaccactgt tgttgggaaa aattaatgat gaggtggatt
     2521 tggttttagt tttgctttgt gataaactct gtacccctga ctggcctggt acttactatg
     2581 tagacctggc taacctccga ctcagaggtg tgcctgtatg tccccaggta ctgggattaa
     2641 aggtttgtac tgcca
//
LOCUS       NM_001191697            4620 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus centrosomal protein 120 (Cep120), transcript
            variant 1, mRNA.
ACCESSION   NM_001191697 XM_225760
VERSION     NM_001191697.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4620)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 4620)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4620)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 4620)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   5  (bases 1 to 4620)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001191697.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1949000.1,
                                           SRR26360181.1904640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000018.1  49388146-49388277   c
            133-198             JAXUCZ010000018.1  49387941-49388006   c
            199-355             JAXUCZ010000018.1  49383840-49383996   c
            356-470             JAXUCZ010000018.1  49382222-49382336   c
            471-612             JAXUCZ010000018.1  49379306-49379447   c
            613-761             JAXUCZ010000018.1  49375066-49375214   c
            762-959             JAXUCZ010000018.1  49373255-49373452   c
            960-1187            JAXUCZ010000018.1  49370600-49370827   c
            1188-1404           JAXUCZ010000018.1  49369293-49369509   c
            1405-1582           JAXUCZ010000018.1  49367897-49368074   c
            1583-1732           JAXUCZ010000018.1  49365316-49365465   c
            1733-1915           JAXUCZ010000018.1  49364545-49364727   c
            1916-2012           JAXUCZ010000018.1  49361228-49361324   c
            2013-2171           JAXUCZ010000018.1  49360986-49361144   c
            2172-2261           JAXUCZ010000018.1  49358919-49359008   c
            2262-2354           JAXUCZ010000018.1  49354506-49354598   c
            2355-2516           JAXUCZ010000018.1  49352257-49352418   c
            2517-2639           JAXUCZ010000018.1  49348629-49348751   c
            2640-2738           JAXUCZ010000018.1  49344147-49344245   c
            2739-2884           JAXUCZ010000018.1  49331773-49331918   c
            2885-4620           JAXUCZ010000018.1  49326266-49328001   c
FEATURES             Location/Qualifiers
     source          1..4620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4620
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
     exon            1..132
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="upstream in-frame stop codon"
     exon            133..198
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3119
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein 120kDa; coiled-coil domain containing
                     100; centrosomal protein of 120 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 1"
                     /protein_id="NP_001178626.1"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
                     /translation="MVPKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPV
                     DHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTA
                     QETKQAPKWYQLLSNKYTKFKSEVQISITLETDTKAQVDSFKAKGAPPRDGKVPASLL
                     GVDPKDIVAVLNEEGGYHQIGPAECCTDSFTLSVTIAFATQLEQLIPCTMKLPERQPE
                     FFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEVLRVYLALHSKLQIHLCCG
                     DQSLGSTEIPLSGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPVELAPTVGV
                     SVALQREGIGSQSLIELKTQNGHEPEHSQKRVLTPIKEKTLTGPKSPRVSPAPPQNQT
                     PPTKDDATESEVESLQYDKEPKQVVKGTGSIPASLAQPEATGNPSEVVTSGQKIAVPA
                     TSHHFCFSIDLRSIHGLEISFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQ
                     SYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFL
                     GANGEQCWRQTYSEKVPVIAAQGSNNRIVDLSYTMTLEDYGLVKMREIFVSESSQGMS
                     AVGQRASPPPPPPAPCPSEIQVEPRETLEYKAALELEMWKEMQEDIFESQLKQKELAH
                     MQALAEEWKKRDRERESLVKKKVAEYSILEGKLQQALTELESREQQLVTAETELQRER
                     KELQLERERNLQELQDSVRRARDDCVHQVELERLKLKQLEEDKHRLQQQLNDAENKYK
                     ILEKDFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALK
                     ELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTEQQELLDIRNELNRLR
                     QQEQKQYQDYKEIASGKQGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIIS
                     ELDRQIREVLTKNSASN"
     misc_feature    174..491
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    174..491
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    501..1169
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    501..1169
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <2106..>3110
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <2106..>3110
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            199..355
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            356..470
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            471..612
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            613..761
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            762..959
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1187
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1404
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1582
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1732
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1915
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2012
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2171
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2261
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2354
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2516
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2639
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2738
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2884
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..4620
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgccct ttgtcctcca acctcccccg ggctctcggc ccgcgggcct ggttgctagg
       61 cggaagcggg gcgcggcggc gtccgctgcg gctgcccggg cgtttgaata gcggcttagc
      121 aggcggcaaa agaccccgcc gccacgacca tggtccccaa gtccgaccag ctgctcatcg
      181 tcgtatccat cctcgaaggt cgccatttcc ccaaacgtcc aaagcatatg cttgtggtgg
      241 aagcaaagtt tgatggggag cagttggcca ctgatcctgt cgaccatact gaccagccag
      301 aatttgctac tgagttagcc tgggagatcg acaggaaagt ccttcatcag cacaggttac
      361 agcgcactcc catcaaactg cagtgctttg ccttggatcc tcagacttct gccaaggaaa
      421 ccgtaggcta cattgttttg gatttaagaa cagctcaaga aacaaagcag gcacccaaat
      481 ggtaccagtt gctgagtaac aaatacacca aattcaagtc cgaggtacag ataagcatca
      541 ctttggaaac agatacaaag gcacaggtgg atagttttaa agcaaaagga gccccacctc
      601 gggatggaaa agttcctgct agcctgttag gagttgaccc taaggacatc gtggcagtgt
      661 tgaatgagga gggaggctac catcagattg gaccagcaga gtgttgtact gactccttta
      721 ctctctcagt gaccatagca tttgccaccc agttggaaca gttaattcca tgtaccatga
      781 agcttccaga aaggcagcct gagtttttct tttactattc tttattggga aatgatgtta
      841 caaatgagcc gtttagtgat ttgatcaacc cgaactttga gccggagagg gcgtctgtcc
      901 gcatacgaag cagcgtggag gtccttcgtg tgtacctggc tcttcactcg aaactgcaga
      961 tccatctctg ctgtggagac cagtcactcg gcagtacaga aatacctcta agtggattac
     1021 tgaagaaggg cagcacagag attaaccagc atccagtcac agtcgagggt gcgtttaccc
     1081 ttgaccctcc aaaccgagcc aagcagaagc tcgctcctgt tcctgtcgag ctggccccaa
     1141 ctgtgggagt gtcagtggct ctgcagagag aaggcatcgg ctcccagtct ttaattgaat
     1201 taaagaccca gaatggacat gagcctgagc actcacagaa gagagtttta acccccataa
     1261 aggagaagac actcactggg ccaaaatcac caagggtgtc ccctgcccca cctcaaaacc
     1321 agacacctcc aaccaaggac gatgccacag aaagtgaagt ggagagcctg cagtacgata
     1381 aggagccgaa gcaggtggtg aagggcactg gttccatacc tgcttcgctg gcccagccag
     1441 aggcgactgg caacccatca gaagtggtga catcggggca gaagattgct gttccagcaa
     1501 catcacacca cttctgcttt tcaatagact tgagaagcat ccatggcttg gaaattagtt
     1561 ttccagtcaa ctgcatattg aggtactcct acccattctt cggcagtgca gctcctatta
     1621 tgactaaccc tcctgtagaa gttcggaaga acatggaagt ttttcttcct cagtcttact
     1681 gtgcatttga ttttgcaact atgcctcacc agctacaaga caccttccta aggattccac
     1741 tgcttgtaga actatggcac aaggataaaa tgagtaaaga cttactcctt gggattgcaa
     1801 gaattcagct ttctaacatc ttgtcttcag aaaagacccg gtttctaggt gctaatggtg
     1861 aacagtgctg gcgacagact tacagtgaga aagtgcctgt catagcggcc caggggtcaa
     1921 ataacaggat agtagacctt tcttacacaa tgactctgga ggactatggc ctggtgaaaa
     1981 tgcgtgagat ctttgtatct gagtcatctc agggcatgtc tgctgtgggt cagagggcgt
     2041 ctcctcctcc tcctcctcca gctccttgcc cttctgagat ccaggtggag ccccgggaga
     2101 ccttagagta caaggctgca ctggagctgg agatgtggaa agagatgcag gaggacatat
     2161 ttgaaagtca gctgaagcag aaagaactgg ctcacatgca agctcttgca gaagagtgga
     2221 aaaaaaggga ccgggaaaga gagtcactag tgaagaaaaa ggtagctgag tacagtattc
     2281 tagaaggcaa acttcaacaa gccctaacgg agctcgagag ccgagagcag cagcttgtca
     2341 ctgcagagac agagcttcaa agagagagaa aggaactgca gttagaacga gagcggaacc
     2401 ttcaagagct gcaggactct gtccgaaggg ccagagacga ctgcgtgcac caagtggagc
     2461 tggagaggct gaagctgaag cagctggaag aggacaaaca ccgccttcag cagcagctta
     2521 atgatgctga aaataagtat aagattttgg aaaaagattt tcagcagttc aaggaccaac
     2581 aaaacaacaa accagaaata cggctgcagt cagaaataaa cctcctcacc ttggaaaagg
     2641 ttgaacttga aagaaagttg gagtctgcaa ccaagtctaa actgcattac aagcagcagt
     2701 ggggccgagc tttgaaagaa cttgccagac tcaagcagag ggagcaagaa agccaaatgg
     2761 ctcgccttaa aaaacagcag gaggagttgg agcagatgcg gctgcgttac ctggctgctg
     2821 aggagaaaga cacagtgaaa actgagcaac aagaactgct ggacataagg aacgaactga
     2881 acaggttacg gcagcaagaa cagaaacagt accaggacta caaagagatt gcaagtggga
     2941 aacagggcag ccctcggggc tctgggctgg aagaaggcct ggatgactac ttgacacgtc
     3001 tgatagaaga acgggatact ttgatgagaa cgggtgtcta taaccatgag gaccgcataa
     3061 taagtgaact cgaccggcag atcagagagg ttttgacaaa aaacagtgcc agtaattaaa
     3121 tgcattgagg aagtctttac agctactcta ggtctgtgtt ttgaattttt tgtaaactcc
     3181 tcaaaagcaa ggaaaacggc gactttagag tgctcttttt aattttttat aagctgaatt
     3241 ttatatatta ctgtatatag tatttatttg attttactta cgctacctct ccaatgctgg
     3301 tttcatttgt aattgtattt tatatgctca tttaaaatga cttttcagtg ttcttcagtt
     3361 caaaatctat tgtttgactt taaaaacagc ctttcagaac ttatcccagg agaactggcc
     3421 acagtagttc ccagctatat aagtttttta tgttgagtca agagagtatg tgttgcactt
     3481 taaaaatgct gtgccctgtt ccctttgatt gtagatatct tcaaattaaa gccaattata
     3541 agtgtagcca tttttaaaaa agcatttata tgaccagtct ttttccctta acctgtggta
     3601 tttgcacatg acaactttga aaataaagca gtcacaggca gaaaagctat gtgacatgtt
     3661 ggctgacaaa ttagtcattg cttaaataca gttcatgtag attaagttta aaaacaaatt
     3721 cggaatttca ctggactcca ttttaagaat gtgagaaaac agcttgttct gatcgcagcc
     3781 tcctgctcac agctgcatga ggctggttgt cgttaaaatt gtaggtcgcc tttgtctctc
     3841 agtggtggca gtacagcttc agacagactg aggaaacaga cacctagcga cattagctga
     3901 gaacaccttc ctccctctgc agtcattctg ttttccaaga ggcagtgcag cgtgagtcgt
     3961 gtaagccgca gagcttccct ccgtgttctc cagaccacct cagcctcatg gcggcactca
     4021 tccctatgtc tgcacaacaa tgaacaggtt agtgagcaaa ctcccagttc atgtgcgatc
     4081 ttaaaacata gaaagtaaaa attctgattc cccaaaataa cagatgtaag tgtatccttc
     4141 ggcaagtatg agctaattac cagtcacttc agcataagca aagcgggtta cacggtaatc
     4201 ttcactaggt gtgtttctgg tttgtgaaat taaagcctcc ataggagtca tatgcttctt
     4261 ttctttaatt ttccgtcttt gtcttctaaa agcaactgag cagtaaatca cagaaaggct
     4321 gctgggtctg agggtggtga gacagatgat catagcaggg atttgaaata tgaattatgg
     4381 ttacacggtc ctgattttct tggtgacatg aatggagcaa aaggattttt gttttagaag
     4441 gtcctggccc aatgttggtt cttcctcctg tatcctgtga ggcctggagc ttttcaaaca
     4501 ctagaggggg cctaagagta agcagaagga cttctaaaat gtgtgtgtgc tttgccttca
     4561 agaaagccat ctttgagcta ctgtaatttg acaaataaaa tcctcactgc gtgcatcctt
//
LOCUS       NM_001437399            4343 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 3, mRNA.
ACCESSION   NM_001437399 XM_063277213
VERSION     NM_001437399.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4343)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4343)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277213.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77209.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000018.1  41088223-41088526   c
            305-539             JAXUCZ010000018.1  41084042-41084276   c
            540-637             JAXUCZ010000018.1  41083584-41083681   c
            638-963             JAXUCZ010000018.1  41075830-41076155   c
            964-1110            JAXUCZ010000018.1  41073397-41073543   c
            1111-1206           JAXUCZ010000018.1  41065895-41065990   c
            1207-1460           JAXUCZ010000018.1  41061600-41061853   c
            1461-1585           JAXUCZ010000018.1  41061277-41061401   c
            1586-1876           JAXUCZ010000018.1  41059874-41060164   c
            1877-2174           JAXUCZ010000018.1  41049807-41050104   c
            2175-4343           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4343
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..304
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            305..539
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..637
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    634..636
                     /gene="Trim36"
                     /note="upstream in-frame stop codon"
     exon            638..963
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..2529
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 3"
                     /protein_id="NP_001424328.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAI
                     MCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCP
                     EHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKE
                     SQVKSQISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRL
                     DKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRP
                     AAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKA
                     DSYVLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRE
                     LVLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSL
                     DYIIGDVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGH
                     DSGSEDAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGK
                     VSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV"
     misc_feature    <673..714
                     /gene="Trim36"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    <673..714
                     /gene="Trim36"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    790..954
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    790..954
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    967..1101
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    967..1101
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    1105..1479
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1105..1479
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1414..1560
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1414..1560
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1630..1821
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1630..1821
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1885..2496
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     misc_feature    1885..2496
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     exon            964..1110
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1206
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1460
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1585
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1876
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2174
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..4343
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtccgcg cgagccgccg ccgcagccgg cagcggggcg tcattcgccg ctccctgggc
       61 cctcgcaggg agcaaccgca ctctccgcgc ccgtgctttc gcctgcgccg gccagtccct
      121 cgccgcgtgg cccgctggcc ggatctggcg gaccagcttg ccctccggtc tgacccgagg
      181 ctcccgaatc gccgcgggga ctcgcccaca cgaccctgct ggggcccgct gcgcctgtaa
      241 agactcggtg gttgatgtca cccggcggag ggctgcgatg gagggggatg cttcagactc
      301 tcaggtgact atcaagaata tcgaaaagga gcttatttgc ccagcatgca aggagctgtt
      361 tacacacccg ctgatccttc cctgccagca cagcgtctgt cataaatgtg tgaaagaact
      421 cttactgtct cttgatgact cattcaacga tgtggcgtca gacagctcta atcagagcag
      481 ccctcggctc cggctcacct cccccagcat ggataaaatc gacaagatta acagaccagt
      541 gtatgtctgt gtaccatgtg cctgcaatat cctctcagac tagaagatgg catcagatcc
      601 cctgggactg aagttacagt tggttgtaag ccataatgct ggaagcgtaa ttcactgacc
      661 cccagaccaa ccatgtttcc ttgtcctggc tgcgagcatg atgtggatct tggagagcga
      721 ggagtcagtg gtctgtttcg aaatttcact ttggaaacga ttgtcgagag gtaccggcag
      781 gctgctaggg cagccacagc cattatgtgt gacctttgta aaccaccacc ccaggaatct
      841 acaaagagct gcatggattg tagtgcaagc tactgcaacg aatgcttcaa aatttatcat
      901 ccctggggca cggtaaaagc ccagcatgag tatgtgggcc ccaccactaa tttcagaccc
      961 aagattttaa tgtgcccaga acatgagaca gagagaataa acatgtactg tgaactgtgc
     1021 aggagaccgg tttgccacct ctgtaagttg ggtgggaatc attccaatca ccgggtaacc
     1081 accatgagca gtgcctacaa aacattaaag gagaaacttt caaaagacat tgatttcctt
     1141 attggtaagg aaagccaggt gaagagtcaa atttctgaac taaacttgtt aatgaaagaa
     1201 acagagtgca atggagagag ggcgaaggaa gaagcgctgg cacattttga gaagctcttt
     1261 gaaatcctgg aagacaggaa gtcgtctgtt ctgaaagcca tagatgcctc taagaaacta
     1321 agactagata aatttcacac tcaaatggaa gagtaccaag gccttctaga gaataacggg
     1381 cttgtgggat atgctcagga agtgctgaag gagacggatc agtcttgctt tgtgcagaca
     1441 gcaaagcagc tccatctcag aatacagaaa gctacagaat ccctgaagag ctttagacct
     1501 gcagcccagg cttcttttga agactatgtt gttaacattt cgaaacaaac agaggtgctt
     1561 ggagaattgt cctttttctc tagtggcata gacattcctg agatcaacga ggaacagagt
     1621 aaagtgtata ataatgccct gatagactgg caccatccag aaaaggacaa agccgacagc
     1681 tatgttctcg aataccgcaa gattaataga gacgaagaaa tgatatcctg gaatgagata
     1741 gaagttcatg gcacaagtaa agttgtctcc aatcttgaaa gcaacagtcc ctatgcgttc
     1801 cgagtgagag cttacagggg ttctatctgc agtccctgca gtcgagaact ggttctgcat
     1861 actcctccag ctccagtttt cagtttcctg tttgatgaaa agtgtggcta caatactgag
     1921 catctcttgc tgaacctgaa gagagaccgg gtagaaagca gagctggatt taatgtcctc
     1981 ctcgctgcgg aacgcatcca agtgggccat tacacaagct tagactacat catcggggat
     2041 gtcggaatca cgaaaggtaa acacttctgg gcctgccgtg tggaaccgta ttcatacctg
     2101 gtgaaagtgg gagttgcttc cagtgacaaa ctgcaagagt ggctgcgctc tccccgggac
     2161 gcagctagtc caagatatga gcaagacagt gggcatgaca gcggaagtga ggacgcctat
     2221 tttgattctt cacaaccgtt tacattagtt actataggca tgaagaaatt ttttataccc
     2281 aagtcaccta cttcttctaa tgaacccgaa aacagagttc tccccatgcc aacaagtata
     2341 gggattttcc ttgactgtga taaaggcaaa gtgagcttct atgatatgga ccacatgaaa
     2401 tgcctatatg agcgccaggt ggactgttca cacacaatgt accccgcttt tgcgttaatg
     2461 ggcagtggcg ggatccagct tgaggaaacc atcaccgcga agtatctgga atatgaagag
     2521 gatgtgtagc ttggacaccc cacaggacga ggatcagaac tgtgaacaaa gccatgccgt
     2581 ggtgttagag tcttcgtaac taattacata tcatttacgt ctctgtcacc acacctgttt
     2641 gtactgtgtg attctttgtt ttgttttgtt ctgctttgac acacacagtc tcagtgtgta
     2701 gtccaggcca gcttcaaact ctgttctgtt atagcctcct taggggctgg gattataggc
     2761 aggcaccacc atacccagct agtgtatgat tcacaacttt tttcatgtca taatggtctt
     2821 accttttaca aatggtggga gtagagactt gtcttaactg gtccaggata gataactcta
     2881 caatggaagt ccttctcttt ggggacaagg actctaattg atgtaagtca gctgatggtg
     2941 gtattattcc tgtccctttg tttgggggtt gcagtgggat acaaagtatt tacaaagttc
     3001 tttgtgcttg ttttcttctt tccttttcat tgtgtatcat gttcatgtcc aaagagaaga
     3061 tatttttaaa tgtttatcga tagaaattag tactaagcca tgtgtcttgc atttgatgtt
     3121 aataggaaaa taaatttaca gataggtaaa atgatgaagg ccataaaatg gtagtatatt
     3181 taagtagaaa attatgtatt ttaaagtgtg taactactga gtgtatattg cctggcaaac
     3241 gaatactgct ttttccctct atagaccaca gactgtattg gtaagaatat ctctaagagt
     3301 gtctttgctg tagtgcccat tgtcctgtac atgtagcaag catcgtttca tataagaaac
     3361 acagggttct tgaacccatg cgactttcca ctacaataga attctttttc aggaaatttt
     3421 attttcaaat tttcttattt tagaaaatac tcatttatag caaagaatta tttttcagaa
     3481 atactaggga agatggactg atagtgaaca cctatctttt tgtgtcttgt gaactttatg
     3541 attttggtac atatgttata catcagggtt ttctggcttt tgtttacaga tttgagaagt
     3601 ttgctgtcca ttttcagcgt tgttgaatgc cagacatgtt acatgttact actgtccact
     3661 tggatggcac tgtttgtggg ctcattgtgt ggtcataagc atttgtagtg tgaatcagta
     3721 aaatacaaaa ttccttagac ataatagcta aacatcacaa ggatgtgtct agtcagtttt
     3781 tacacctttt ctacactaga tgttaatttc tgcaaggtta ctttccaatt atttgaattg
     3841 cctttttaaa agttaaaatg tccagacact aagacttaca tgtgttcagc actgatcatg
     3901 caatggaatg gtagcatttt ggtagaataa ccaaagctgt ttatttgatt gattcttttt
     3961 aatggaagcc tgttgggcta atcacactgc atctgaccca gcactgactg gtacgcatcc
     4021 ctacgcttgt gtagaaatat ctggaggatt tgtgtttagt gattgccctt cctctcccac
     4081 ttatatctag cactttatga cataggaaac agagagaatg tgcagtgtta cctggggtca
     4141 ttgtgcaata atgctgctaa agtcgccgca cgtgtgggtt agtgtgacac tcaatattca
     4201 tgtaagcaca tgtcctgtag acattttaaa atataaagct ttaactggag tcagagaagc
     4261 gagctgttcg aacactgtat cactgtatag aaattgctta gtggaattcc acttttttaa
     4321 aataaaaaaa taaataaagg gaa
//
LOCUS       NM_001437359            1979 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 8, mRNA.
ACCESSION   NM_001437359 XM_063271320
VERSION     NM_001437359.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271320.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000012.1  40090950-40091098
            150-250             JAXUCZ010000012.1  40093232-40093332
            251-420             JAXUCZ010000012.1  40093729-40093898
            421-610             JAXUCZ010000012.1  40096705-40096894
            611-730             JAXUCZ010000012.1  40098953-40099072
            731-912             JAXUCZ010000012.1  40100973-40101154
            913-1094            JAXUCZ010000012.1  40102786-40102967
            1095-1315           JAXUCZ010000012.1  40106323-40106543
            1316-1390           JAXUCZ010000012.1  40109132-40109206
            1391-1583           JAXUCZ010000012.1  40110908-40111100
            1584-1787           JAXUCZ010000012.1  40112332-40112535
            1788-1979           JAXUCZ010000012.1  40113629-40113820
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1979
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..149
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            150..250
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    245..247
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             251..1927
                     /gene="Ccdc63"
                     /note="isoform 2 is encoded by transcript variant 8;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     2"
                     /protein_id="NP_001424288.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVEYPLDHSSLRQLVLENYLQKERGKEPQETLLEKGDEIRVKKKVIS"
     misc_feature    <686..1507
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <686..1507
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            251..420
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            421..610
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            611..730
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            731..912
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1094
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1315
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1390
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1583
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1787
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1979
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggta agttagggta cacacagcgc
       61 cccctgccgg cgatgagcac aggctggggg ctccggcaag ccaggaacca gcaactgcca
      121 ccgtaaatgc tccccaagcc caaagagcgg acattgcaga cagaggagac actgagagaa
      181 cgagaaagaa gtgggcttgc tagctttgac ctccaggacc cagtgtctaa gcagaaagga
      241 agcttagacg atgaagaaac acaggaggaa ggtctctgaa ccccttccgg aactttccga
      301 gaaggccaaa gagcagttgg ctgaggcaga gctacggaaa ctaaggcagc agttccggaa
      361 gatggtagac agccgaaagt cttccaattt ccgcaaccag cggatgatcg ccagccagta
      421 caaggagata gagaatttga aagcggagca ggcagagacc accttgcttc tgagcctcgt
      481 gaagtcgcca aagaacctag acctcaacca gaaaaatttc acggagctgc gcttcctgct
      541 gcagaccaag ggggactacg aggctctgat ctcctccatg aaggtgctgc tgggagaact
      601 ggatgacaag attgttcaga tggagagaaa gatcacaaac cagagacaga tcttcttgaa
      661 gacacaagag gccaacaatc cccggaagct gcagaaacag atccacattc tggagaccag
      721 actgaacctg gtcactgtcc actttgacac gatgttgacc tccaatgccc agctccggaa
      781 ggatattgag gatcttctct ttgagaaggc tgcctacgac catgtctacc agcagcttca
      841 gcggcgtctg cagacacaga agaagaccat gaatgtggcc atcgagcagt ctacccaggc
      901 ctatgagcag agagtggaag ccatggctcg gatggctgcc atgaaggacc gccagcaaaa
      961 agacatctct cagtacaacc tggagatccg agagctcgaa cgcctgtatg accacgagaa
     1021 caaactcaag tcctttctgc ttgtcaagct caatgaccgc acggaattcg aggaccaggc
     1081 caagaagcag gaagctgtca aaattaagaa gcatgggaaa aagaggaagg gtgagagctt
     1141 tgagagctac gaggtggccc atctccgact gctaaagctg gctgagaacg gggacctgaa
     1201 ccagctcact gaggacttcc tggccaagga ggagaagaat tttgctcgct tcacctatgt
     1261 caccgagctc aacaatgaca tggagaccat gcacaagagg acccagcgga tccaggatga
     1321 catcatcaac ctgcggtcac agcagcagtc ctcccatgag ggcacccgga acatcctgaa
     1381 acagatggag gagaaactga ggaagaccac cgaggacacg gacatttatg agaacaggta
     1441 cagggaaatg agcaagaccc tggagtacct caagaactca gtggagaagc tgtttaagaa
     1501 gatcaactgc aatgccacgg agatcctggg gaaactgggt gagactggga agatcacgga
     1561 cagcaacctt cagcagtact tcgctatcat agaaaagaag acaaatgacc tcctgcttct
     1621 ggagtctttc cggcgcctgc aggaggcaga ggggcccgat gttgatgtcc cacaaccctt
     1681 tgtcaacccc ttctgggggg gctctgccct cctcaagccc ccagagccct taagggttgt
     1741 gccgcctgtg tttggggcag actccttcag tgacaaagtt gaagaggtgg aataccctct
     1801 ggaccacagt agcctccggc agctggtctt ggagaactac cttcagaagg aacgaggaaa
     1861 agaaccacag gagacactgt tggagaaggg ggacgagata agggtcaaga agaaggtgat
     1921 aagctgaacc ccgtgggtgg ctgtattcca caccgagaaa ataaatgttt tcttgccga
//
LOCUS       NM_001437297             823 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437297
VERSION     NM_001437297.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 823)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2458210.1,
                                           SRR26360172.988737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-290             JAXUCZ010000011.1  44823304-44823443
            291-823             JAXUCZ010000011.1  44825271-44825803
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..823
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..417
                     /gene="Mrps6"
                     /note="isoform 3 is encoded by transcript variant 4; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 3"
                     /protein_id="NP_001424226.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MPRYELALILKAMRRPETAAALKRTIESLMDRGAIVRNLENLGE
                     RALPYRISSHSQQHSRGGDSARTSLFVGEGLMESHIAEGATGGGVLSTLSKKGEHLPE
                     A"
     misc_feature    112..>288
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    112..>288
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     exon            151..290
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            291..823
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg ccagagaccg ctgctgcttt aaaacgtaca
      181 atagaatccc tgatggaccg aggagccata gtgaggaact tggaaaacct gggtgagcgt
      241 gcactcccat acaggatctc cagtcacagc cagcagcaca gccgaggagg agactcagcc
      301 cgaacctcac tgtttgttgg agagggttta atggagtcac acattgcaga gggagcaacg
      361 ggaggaggtg ttttgtcgac tctttctaaa aagggcgagc atctccctga ggcctagtga
      421 tactccactg cacagcagcc agcctcactc caggactgca caccgtttga agctctttgc
      481 actaggtgct ggagggagga cagcaaaaga actggtgatc tctcagtgct gaacttgtgt
      541 gtccggtggc ctgtgactgg ccaggagact gggctcactt ccatgcttgt aagaactctt
      601 cagttggggg ctggagagat ggctcagagg ttaagagcac tgtctgctct tccagaggtc
      661 ctgagttcaa ttcccagcaa ccacatggtg gctcacaacc atctatagtc aggtctggtg
      721 ccctcttctg gcctgcagac atacatgcag gcagaaagct gtatgatgta tacataataa
      781 ataaataaat gttaaaaaaa aatctttaaa aaaaaaaaaa gaa
//
LOCUS       NM_001437255             971 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17),
            transcript variant 2, mRNA.
ACCESSION   NM_001437255 XM_039089223
VERSION     NM_001437255.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 971)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 971)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 971)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 971)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039089223.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1139249.1,
                                           SRR26360194.2275248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000012.1  32587681-32587880   c
            201-340             JAXUCZ010000012.1  32586490-32586629   c
            341-971             JAXUCZ010000012.1  32584816-32585446   c
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..971
                     /gene="Mrps17"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
     exon            1..200
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     exon            201..340
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..601
                     /gene="Mrps17"
                     /note="28S ribosomal protein S17, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_001424184.1"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
                     /translation="MSIVRSAVHAKWVVGKVIGTAMVKTAKVRATRLVLDPYLLKYFN
                     KRKTYFAHDALQQCSVGDIVLLRALPVPRAKHVKHELAEIIFKVGRVIDPVTGKPCAG
                     TAYLESPLSSEATPPCESREELKSS"
     misc_feature    248..469
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     misc_feature    248..469
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     exon            341..971
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgcc caggctcctc cggccttggt ccgagttgta ggttttggag gtgagcgagg
       61 gctacggatc tgggtattgg gttcggcagt gctacgtctc ctgttactct ccctggtggt
      121 ttcggtagca aatgattccc aaagcggctc cgagtcaaag tctcgttgtt cctgtacagg
      181 aagctggctg accggccgag gcgctcacag acacataatg tcaatagtcc gttcagccgt
      241 ccacgccaaa tgggttgtgg ggaaggtgat tggtacagca atggtaaaaa ctgctaaagt
      301 aagagcgacc agacttgttt tggatcccta cttactaaag tactttaata agcggaaaac
      361 ctactttgct catgacgccc ttcagcagtg cagcgtcggg gacatcgtgc tcctcagagc
      421 tctgcccgtc ccacgagcaa agcacgtgaa acacgaactg gcagagatca tcttcaaagt
      481 gggccgagtt atcgaccccg tcacaggaaa gccctgtgca ggaaccgcct acctggagag
      541 ccccctcagt tcagaagcca ctcccccctg cgaatctcga gaagagctca agtcctcctg
      601 aacctgggga agagggagcc agaggatgga tgtctgtctg tttgctcagt ggcttttcat
      661 actgtttctc ctgtgacatt agaagtattc aacagagtaa agagcttagc gttccataaa
      721 ggttcgcatc ctttttcaga ttctctgccc tgaagttacc ttccgagtac tctgtatgcc
      781 taagcgtgct gcgtcattcc gtaagctcac tgtcctagat catatatgta ttgttttgtt
      841 tgccatcact caaagaaatc ttggactttg cacctttatt ttaaaagaag aaaacctttt
      901 gataataaca gaaaaggcta aacttagttt cgatagctga atttttcaaa atatatcgtg
      961 tgtgtccaca a
//
LOCUS       NM_001437360            1766 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 9, mRNA.
ACCESSION   NM_001437360 XM_063271321
VERSION     NM_001437360.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271321.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.595138.1,
                                           SRR26360181.1357217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-207              JAXUCZ010000012.1  40093729-40093898
            208-397             JAXUCZ010000012.1  40096705-40096894
            398-517             JAXUCZ010000012.1  40098953-40099072
            518-699             JAXUCZ010000012.1  40100973-40101154
            700-881             JAXUCZ010000012.1  40102786-40102967
            882-1102            JAXUCZ010000012.1  40106323-40106543
            1103-1177           JAXUCZ010000012.1  40109132-40109206
            1178-1370           JAXUCZ010000012.1  40110908-40111100
            1371-1574           JAXUCZ010000012.1  40112332-40112535
            1575-1766           JAXUCZ010000012.1  40113629-40113820
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1766
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1714
                     /gene="Ccdc63"
                     /note="isoform 2 is encoded by transcript variant 9;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     2"
                     /protein_id="NP_001424289.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVEYPLDHSSLRQLVLENYLQKERGKEPQETLLEKGDEIRVKKKVIS"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            38..207
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            208..397
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            398..517
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            518..699
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            700..881
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1102
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1177
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1370
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1574
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1766
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtgatg aagaaacaca ggaggaaggt
       61 ctctgaaccc cttccggaac tttccgagaa ggccaaagag cagttggctg aggcagagct
      121 acggaaacta aggcagcagt tccggaagat ggtagacagc cgaaagtctt ccaatttccg
      181 caaccagcgg atgatcgcca gccagtacaa ggagatagag aatttgaaag cggagcaggc
      241 agagaccacc ttgcttctga gcctcgtgaa gtcgccaaag aacctagacc tcaaccagaa
      301 aaatttcacg gagctgcgct tcctgctgca gaccaagggg gactacgagg ctctgatctc
      361 ctccatgaag gtgctgctgg gagaactgga tgacaagatt gttcagatgg agagaaagat
      421 cacaaaccag agacagatct tcttgaagac acaagaggcc aacaatcccc ggaagctgca
      481 gaaacagatc cacattctgg agaccagact gaacctggtc actgtccact ttgacacgat
      541 gttgacctcc aatgcccagc tccggaagga tattgaggat cttctctttg agaaggctgc
      601 ctacgaccat gtctaccagc agcttcagcg gcgtctgcag acacagaaga agaccatgaa
      661 tgtggccatc gagcagtcta cccaggccta tgagcagaga gtggaagcca tggctcggat
      721 ggctgccatg aaggaccgcc agcaaaaaga catctctcag tacaacctgg agatccgaga
      781 gctcgaacgc ctgtatgacc acgagaacaa actcaagtcc tttctgcttg tcaagctcaa
      841 tgaccgcacg gaattcgagg accaggccaa gaagcaggaa gctgtcaaaa ttaagaagca
      901 tgggaaaaag aggaagggtg agagctttga gagctacgag gtggcccatc tccgactgct
      961 aaagctggct gagaacgggg acctgaacca gctcactgag gacttcctgg ccaaggagga
     1021 gaagaatttt gctcgcttca cctatgtcac cgagctcaac aatgacatgg agaccatgca
     1081 caagaggacc cagcggatcc aggatgacat catcaacctg cggtcacagc agcagtcctc
     1141 ccatgagggc acccggaaca tcctgaaaca gatggaggag aaactgagga agaccaccga
     1201 ggacacggac atttatgaga acaggtacag ggaaatgagc aagaccctgg agtacctcaa
     1261 gaactcagtg gagaagctgt ttaagaagat caactgcaat gccacggaga tcctggggaa
     1321 actgggtgag actgggaaga tcacggacag caaccttcag cagtacttcg ctatcataga
     1381 aaagaagaca aatgacctcc tgcttctgga gtctttccgg cgcctgcagg aggcagaggg
     1441 gcccgatgtt gatgtcccac aaccctttgt caaccccttc tgggggggct ctgccctcct
     1501 caagccccca gagcccttaa gggttgtgcc gcctgtgttt ggggcagact ccttcagtga
     1561 caaagttgaa gaggtggaat accctctgga ccacagtagc ctccggcagc tggtcttgga
     1621 gaactacctt cagaaggaac gaggaaaaga accacaggag acactgttgg agaaggggga
     1681 cgagataagg gtcaagaaga aggtgataag ctgaaccccg tgggtggctg tattccacac
     1741 cgagaaaata aatgttttct tgccga
//
LOCUS       NM_001437375            2688 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 5, mRNA.
ACCESSION   NM_001437375 XM_017600882
VERSION     NM_001437375.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 2688)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 2688)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 2688)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 2688)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 2688)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 2688)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017600882.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1401258.1,
                                           SRR26360181.1631580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-989             JAXUCZ010000018.1  70152116-70152226
            990-1058            JAXUCZ010000018.1  70152308-70152376
            1059-1226           JAXUCZ010000018.1  70152876-70153043
            1227-1526           JAXUCZ010000018.1  70153375-70153674
            1527-1664           JAXUCZ010000018.1  70153761-70153898
            1665-1796           JAXUCZ010000018.1  70154230-70154361
            1797-1858           JAXUCZ010000018.1  70154449-70154510
            1859-2688           JAXUCZ010000018.1  70158915-70159744
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2688
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1931
                     /gene="Mbd1"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 5"
                     /protein_id="NP_001424304.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTEL
                     HISDQTPTAPAEFVYDCVEEDELQPYTNQRQNRKCGACAACLRRMDCGHCDFCCDKPK
                     FGGSNQKRQKCRWRQCLQFAMKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSS
                     PLKAPLAVVTTPPGPVQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAAST
                     ENPAQETQGSAPGWVVALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPP
                     PVKREPPGPEEDGEENKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPR
                     LHKLLAVNENEYFTELQLKEEIL"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1071..1211
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1071..1211
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..989
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1058
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1226
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1526
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1664
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1796
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1858
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2688
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaaggg taaatatgat catagtaaga
      901 gaggcccgag ggtagcttct cgacgtcact cccgagcccc gccacttcct ccacacgctg
      961 cgtcacagca tccagagccc acagaactgc acatcagcga ccaaacgccc acagcacctg
     1021 ctgagttcgt ctatgactgt gtagaggagg acgagctaca gccctatacg aaccagcggc
     1081 agaaccgcaa gtgtggggcc tgtgcagcct gcctacggcg gatggactgt ggccactgcg
     1141 acttctgctg tgacaagccc aaattcgggg gcagcaacca gaagcgccag aagtgtcgtt
     1201 ggcgccagtg cctgcagttt gccatgaagc ggctgctgcc cagtattggg ccagggtctg
     1261 aggaggaagc aagattgctt ccacatcata cccaccaaaa gaggtctgct tctactcgac
     1321 agctgcaact gagctctccc ttaaaggctc ctttggctgt ggtcacaacc ccaccgggcc
     1381 ctgtccaaga ttcagggaag cggcaagcag gtagtggctt tgtactgccc caacctgaca
     1441 cagaccttgt gtatttacaa gagggtacca gcagtctcat gcaggtgcct ggccctgctg
     1501 cagcttccac agaaaaccca gcacaggaga cccagggctc tgccccaggt tgggttgtgg
     1561 ccttgcccca ggtgaagcaa gagaaggcgg atgccccaga ggagtggaca gcagtcacaa
     1621 ccttcctgac ttcttccacg gtgcagcctg gcttccttag caaggcgtca ggcctggacc
     1681 ctccacctgt gaaacgagag ccccctggcc ctgaggagga tggagaagag aacaaagaag
     1741 atgatgtctc tgaatcagct ccagcagaag agataggagg gattggcacc ccagtgatca
     1801 cggagatttt cagcctgggt ggaacccgcc tccgggatgc agaagcctgg ttgccaaggc
     1861 tacataaact gttagcagta aatgaaaatg agtattttac tgagctgcag ttgaaagaag
     1921 aaatattgta ggagagaaaa gcaattatta ttaagagaag aaagacattc ttttgtggct
     1981 gaaaagctga acctggaatt caggaaatgg aatctaaatc tagagatgta ccatgtagaa
     2041 aatctgaagt gggtgggtta caaataatta agcacactaa tttgaagaaa accatcctta
     2101 aacatgtgta cacatggatt gcacttagta tctgtcagtg actggcctta ttactgtcct
     2161 cccccttcct cttcttgttc ccccatccct cttaacaggg gcaccacagt agcagtcagt
     2221 ttgctcttaa gcagtgtaac tccgttttat ggttactagg agctacaact ctggtttcca
     2281 tgtatgctga agaccgtcta gtttcctgga ctgcattgcc agttttgcct gggatcccga
     2341 ttctcaagaa ttgagtatct gaacttctga tccgaagctc attcctccag tcagacaact
     2401 gccctgctag tatttctgat ctgccctctt cctgtgttag cccaaagtgt gggccccatt
     2461 ttctgttcag tgcagtagga agattttgtt cacagatctt actggttgtg tagctcgaca
     2521 aggcactttg gcttcctgag ccttagttga cttcactgca aactaaagcc aataccctca
     2581 gttccttcaa ccctgtaaga attttgtcaa cctcaaaggt tgtttctgga aatactttgc
     2641 aaattgtaaa aaaaaaaaaa aaaaaaaaaa aaagagagag aaacaata
//
LOCUS       NM_001437310            5342 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus KIAA1328 homolog (Kiaa1328), transcript variant
            4, mRNA.
ACCESSION   NM_001437310 XM_039097032
VERSION     NM_001437310.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039097032.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.76444.1,
                                           SRR26360181.2656524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000018.1  16764736-16764880
            146-288             JAXUCZ010000018.1  16771469-16771611
            289-383             JAXUCZ010000018.1  16776653-16776747
            384-499             JAXUCZ010000018.1  16794966-16795081
            500-627             JAXUCZ010000018.1  16865059-16865186
            628-1301            JAXUCZ010000018.1  16920208-16920881
            1302-1385           JAXUCZ010000018.1  16927043-16927126
            1386-1567           JAXUCZ010000018.1  16983935-16984116
            1568-1676           JAXUCZ010000018.1  16996889-16996997
            1677-5342           JAXUCZ010000018.1  17047419-17051084
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5342
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="KIAA1328 homolog"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
     exon            1..145
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    145..147
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="upstream in-frame stop codon"
     exon            146..288
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1881
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="protein hinderin isoform 4"
                     /protein_id="NP_001424239.1"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
                     /translation="MESLKGAGDSVAEQSFCKRGLKSASLKDLCVEDKRRIANLIKEL
                     ARVSEEKEVTEERLKTEQESFEKKIRQLEEQNELIIKEREALQLQYRECQELLSLYQK
                     YLSEQQEKLTMSLSELGAARAQEQQITKKKITHQSSLVNLDGSYLSVAKPQTCQTRAR
                     PKSENQDSASESHTALRNNSLKPVTLHHPKQDLERMSTETRTCTYESPGRRLINAAPV
                     EEALPEELKIKDYPNLLPTPSSQYCGHKYSESEAYVHENYHPTNMASQCCKTHPESCS
                     HCRMSWASLMHDGVTLQPRETDIEKQLSEDRRQQLMLQKMELEIEKERLQQLLAQQET
                     KLLLKQQQLHQSRLDYNWLRTQAVFRSRELVADKDFPKPGSDSGPSLLKPKCDGWLRG
                     TSSSFRKCPDSPNSAQNQKEKKTVEFQSHVENGIQWTCQQNDTCRLQRETATGVRKDA
                     STSPMSTQSPKHPLTPASSSSKHKTSRYETSLLDLVQSLSPNSAPKCQPHSSRAAGTW
                     SALRPTPKTSTWKKVGTHKSPEDLEENQILEDIFFI"
     misc_feature    328..1299
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     misc_feature    328..1299
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     exon            289..383
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            384..499
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            500..627
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            628..1301
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1385
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1567
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1676
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..5342
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgggcca gagaagcgtg gcgcggaccc cgggctaggg atgggccttt ccacttcagg
       61 ctgggtgccc gactcgccca tcacctggcg accaagtgtc gctaggtggg aattctggct
      121 catgggtaac ccgcccgcct tagctgaatc tccacagaaa gaaatacaag atcaaggctc
      181 aagttgataa atccaaaagt tgatgctaaa gttaaggttc ccaaggtgac tgatattcct
      241 gcctccatgg agtctttaaa aggtgcagga gattcagtag ctgaacagag tttctgcaag
      301 agaggactga agagtgcgtc attgaaagat ttatgtgttg aggacaaaag gcgcattgcc
      361 aatttaatta aagaactggc cagagtaagt gaagaaaagg aggtgacaga ggagcgactg
      421 aaaactgagc aggagtcctt tgagaagaag atccggcagt tggaggaaca gaatgaactg
      481 atcatcaaag aaagggaagc tcttcagcta cagtatagag aatgtcaaga acttctaagt
      541 ctctaccaga agtacctgtc agagcagcaa gagaagctta ccatgtcgct ctcagagctt
      601 ggagctgcta gagcacagga acagcagata accaagaaga aaatcactca ccagtcttca
      661 ttggtgaacc tggatggttc ctatctgagt gtagccaaac cgcaaacctg ccagaccagg
      721 gccaggccta agtcagaaaa ccaggactca gcttcagaat cccacacagc attaaggaat
      781 aattctttga aaccagtaac acttcatcat cccaaacagg atttagagag gatgtcaaca
      841 gaaaccagaa cgtgtactta tgaatctcca gggaggagac taataaatgc agccccagta
      901 gaggaagctc tcccagaaga gttgaagata aaggactatc caaaccttct gcctactcca
      961 tctagtcagt actgtggtca taaatactct gaaagtgaag cttatgttca tgagaactat
     1021 catcctacga acatggcctc tcagtgttgt aagacacatc cagaatcatg cagtcattgt
     1081 aggatgtcct gggcatctct catgcatgat ggagtgacac tgcaacccag agaaaccgac
     1141 atcgaaaaac aactctcaga agatcgaagg cagcagctga tgcttcagaa aatggaactg
     1201 gaaattgaaa aggaacgcct tcagcaactc ctggcccaac aagagacaaa gcttctcctt
     1261 aaacagcagc agctgcacca atcccgacta gattacaatt ggttaagaac tcaagctgtg
     1321 tttagatctc gagaactggt tgctgataaa gactttccta aacctggaag tgactctgga
     1381 ccaagtttat tgaagccgaa atgtgatgga tggctgcgtg gaacctcatc gtccttcaga
     1441 aagtgcccag actctccaaa cagtgcgcaa aaccagaagg agaagaaaac tgttgagttt
     1501 cagtcacacg tggagaatgg cattcaatgg acatgtcaac agaatgacac atgcagactc
     1561 cagagagaga cagcaactgg agttagaaaa gatgcttcca catctcctat gtcaacacaa
     1621 agccctaaac accccctgac accagcctca tcgtcatcca agcacaaaac ctcaaggtat
     1681 gagacatctc tgttggactt ggttcagtct ctgagcccaa attctgctcc taaatgtcag
     1741 ccccattcct ccagagcagc agggacatgg agtgctctcc gacctacccc taagacatct
     1801 acctggaaga aagtggggac acataagagc cctgaggacc tggaggagaa tcagattctg
     1861 gaagacatat ttttcatatg actctgaagc acatgctaca gaatttccac aggaaatatt
     1921 tgagtttctt tccatattga tgtaggatgt taaactgaaa agaagccgtg tctctccttt
     1981 cgtggagacc tcttgctggc atccttttat agtattgaat atagaaagca ttcttataaa
     2041 tcagggtggt ttttgtcaga ccagttagca gaaacagact aaagggggtc acttagaggt
     2101 aggatctttt ctataccaaa cagaaattag aaattgtgga tactgcctgc atagtaaaac
     2161 ccatgaatgt ctagtgtcat tttaagagtg ttttcaattt actactgcaa aaagttgact
     2221 ctttacagat ggaaaacgtt cccattgaca gaccccttaa atatgaaagt agccacttca
     2281 gaaaggctct tctctcctca ccaatgctaa gtgtggcgct tcattccgac gttgaagttg
     2341 gtgactctaa tatcatctta catgggacca atacttgtgg gtcatagtgg tcaaccgagt
     2401 cattgccacc ccttaaacca aaaggctgaa tgacttagag ggaagtttgc aaccagacag
     2461 tggcattaga ccacatgagg gcatggccgc ctggggaaat ttaccagtgt ccaggcagcc
     2521 acctctccag tgttccatga tgggtgtttc ttgtcgactt cagtgttgta aactttacct
     2581 gtggttgtgt ctgaggaaga tagcactaga ggaagagtgg tgtcgagtgg ctgcaggctg
     2641 gcaggttcct tctgccccac ctcacaccat aggacgagta tcctcctctg agcaccgtgg
     2701 atgcagagtc tgagaacgct ctgctgatta cccttcttgg cccagatcta gatcttttct
     2761 cctcaggctg agctcagtgc tgttggttct actcaggctc cctcccaagc tcatactctt
     2821 cctctgaagc agctgcaagg gcaagactaa ttaccctttg gaaatttaaa gttcattgaa
     2881 aattccaatt ttcttttcaa attcagcctg agagtaacta gaacagactt gttctacttc
     2941 aaaacacctt taggatatgc ctttggaggg gcagaaatag ccatattctc agttgggttt
     3001 ccagaaacat cttttctcta tcttgtgtca aagacagctt aactatacct atttctttac
     3061 acctgctata accatagtca ccgttctgag catcagtagt cttactactc ctgtatatct
     3121 ccagaaggaa aagaaagaga atctgatctc cttaagaagc ttatttacag gtagaagagt
     3181 tgtaaacggc ctaaaaatga aagcttttgt gcagtgacat gccagtgaat agaatttaat
     3241 tgcttcttca ccagcatggg aagtttggaa gagaaaaaag gggggttttc agtcagtaca
     3301 ctttttatac ttcacagatc tgccatgcgt taccttcttc tcatgcatat acatacatac
     3361 atacacacac acacacacac acacggatat atatatatat atatatatat atatatatat
     3421 atatatatat atcctagtga ctttgttatt aaccaaatag tatattgtgg cccatcccac
     3481 agaagaatgg gaagaaagta ggagccatgt gcctccctgg ataatgctct cttcggtggt
     3541 tggttgggac ttgcttggcc agctcctaga tgtttcctcc aagcaaaact gcactcaatg
     3601 ataaaaattt agtttaacaa gattcaccaa ggtcaccaga tagtaaggag caattcaaac
     3661 ccagaggtga agatgggggg aaggggagtc attgttcttt tctttacttc tctttcctat
     3721 tttgagtaaa tatcaaaacc atcaagacca ttttctacag tccagttatt atttatcaga
     3781 cacatggatt ggtaaggaga ggagagcagt gggaagaagg gattaaagga aacaggccta
     3841 catccctttg cagccttggt acaattcctt attgcatgca gttctctcat aaaggagaag
     3901 aggaccagaa gagagaaatg gagatggtgg gctctgggac ccttccactg ctccttcctc
     3961 agtgccttat ctgcagtgtt taatgttttt cttccaaatt taagatttct aactctcata
     4021 cttggaaata caaagaactc cccagggctt acaggtcaag gggcacaggc cctagagagg
     4081 cacatcaggg ctctctgtct ccagccccat gtccctttgc tgcatcagcc gcctccatta
     4141 ccctcttctt tgctccccat tgcagctcac cactgttaga cacatcccaa tggcacactt
     4201 ctcttcccag gtccttctgg gtgaataact taagactaag tttttaccac tttgtgaaat
     4261 tttccttatg ttcctggcac tgtgtactgt tgactccagt aagatgtgca gatatgtcca
     4321 acccataagc cataagctgt gacgtatggt caaggatagc tgtgaatgtg gcccaacaca
     4381 aaattgtaaa cgtaagacat tttgagtagt gtggttattt ttgtttttca cttttgtgtg
     4441 tgtgacttga ttgtgcagct ctcaaacatg aacattgtat ataataaatc atgtcatcat
     4501 gttgctgtgt caaaggctgg ccatgcggca agtccaagcc tctgtggtgg ccctcctcgt
     4561 catgccacat tgtactgggt actgtttgcc tttcttgtta gagttccagg tgtccagact
     4621 aacatatgct atgtcggaga agccaagttc accatttgta acatacagac atgcaggtga
     4681 gttattgata ccttcagata atgataattc tacctgcagt tttaggcctt atctgctgac
     4741 ctagccctaa aagcctagac cagagaaaag ctagaatgag aaggtcaaag ttcccaagaa
     4801 tgtgaagctg acagttgggg ggcactgaga cccatctcct tagaacatgg ggcaaccaac
     4861 agacccaaag gcagggagca gagtcagtgt tagaacagta cagagctggt tgaccagaac
     4921 agtttcattc cagagctgac acccctctgc cctctgtggt ctgacacctg attggctcat
     4981 gccaagcaag cactagcaca aacattgccc acagtgactc ccacccagaa gctccctctt
     5041 tctcttcccc agatgctgcc ccacactctc ctccacactc tttccagctc taggtcctaa
     5101 ggtggccagg aggctgctga gatgagggag accatgctgt atcccaggga aatggggtga
     5161 gcccttagtt ttcaaacctc ctctgagaga ttttaacttg ttggatttat gtagcattgg
     5221 aaaatgataa actgtatgaa ttttctgtat tttccatgga cagttattta tggaggggcg
     5281 tttttaactc aagtgctaga aatgttaaat catcataata aattcatgct attcagactt
     5341 tc
//
LOCUS       NM_001437326            8608 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            2 (Jakmip2), transcript variant 3, mRNA.
ACCESSION   NM_001437326
VERSION     NM_001437326.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8608)
  AUTHORS   Cruz-Garcia,D., Vazquez-Martinez,R., Peinado,J.R., Anouar,Y.,
            Tonon,M.C., Vaudry,H., Castano,J.P. and Malagon,M.M.
  TITLE     Identification and characterization of two novel (neuro)endocrine
            long coiled-coil proteins
  JOURNAL   FEBS Lett 581 (17), 3149-3156 (2007)
   PUBMED   17572408
  REMARK    GeneRIF: NECC 1 & 2 proteins primarily expressed in
            (neuro)endocrine tissues in vertebrates thus supporting a role for
            these proteins in the regulated secretory pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.73921.1,
                                           SRR26360194.391520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000018.1  35998552-35998896   c
            346-622             JAXUCZ010000018.1  35901780-35902056   c
            623-1120            JAXUCZ010000018.1  35893106-35893603   c
            1121-1330           JAXUCZ010000018.1  35889442-35889651   c
            1331-1429           JAXUCZ010000018.1  35887501-35887599   c
            1430-1576           JAXUCZ010000018.1  35883648-35883794   c
            1577-1717           JAXUCZ010000018.1  35882878-35883018   c
            1718-1774           JAXUCZ010000018.1  35880934-35880990   c
            1775-1894           JAXUCZ010000018.1  35879957-35880076   c
            1895-2023           JAXUCZ010000018.1  35878661-35878789   c
            2024-2107           JAXUCZ010000018.1  35876787-35876870   c
            2108-2206           JAXUCZ010000018.1  35872906-35873004   c
            2207-2305           JAXUCZ010000018.1  35871950-35872048   c
            2306-2359           JAXUCZ010000018.1  35871138-35871191   c
            2360-2425           JAXUCZ010000018.1  35870288-35870353   c
            2426-2494           JAXUCZ010000018.1  35866017-35866085   c
            2495-2572           JAXUCZ010000018.1  35856809-35856886   c
            2573-2776           JAXUCZ010000018.1  35854261-35854464   c
            2777-2842           JAXUCZ010000018.1  35848371-35848436   c
            2843-2913           JAXUCZ010000018.1  35845323-35845393   c
            2914-8608           JAXUCZ010000018.1  35833986-35839680   c
FEATURES             Location/Qualifiers
     source          1..8608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..8608
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="janus kinase and microtubule interacting protein 2"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
     exon            1..345
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            346..622
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    482..484
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="upstream in-frame stop codon"
     CDS             494..2893
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     2 isoform 3"
                     /protein_id="NP_001424255.1"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
                     /translation="MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKV
                     SKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSR
                     TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLK
                     TAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR
                     IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHC
                     SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLA
                     KRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL
                     KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMT
                     SFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAERE
                     AKAQEQLQAEVLRYRAKIEDLEATLAQKGQIEKQEAENHRLQQELQDARDQNELLEFR
                     NLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNL
                     RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELD
                     YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRK
                     SREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKFLFLFLFFSLAFILW
                     P"
     misc_feature    548..>2221
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    548..>2221
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    1718..2236
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1718..2236
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    <1919..>2839
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1919..>2839
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            623..1120
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1330
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1429
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1576
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1717
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1774
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1894
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2023
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2107
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2206
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2305
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2359
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2425
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2494
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2572
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2776
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2842
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2913
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..8608
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctaccg cagcaggggt ggggctgtgg gggtggggag ggaaggagga gcctgaggag
       61 gtgtctgctg caagttcctg gctgattctg agctcacacc atcctccaag agggaggagg
      121 ctcaagtgat gctgctgctg ttgccgcctc tactgctggt actctagtgg agctgggaag
      181 ggtggttcct atcgcaccat cgccaaccgg agagggaggg ggaaaaaaat cctggtagcc
      241 gctgctgatg ttgggttcag aggctgcatc cgacccggtc acaagaaaaa tggattcagt
      301 gtgcggctct ccctcttttc agcatcttct cctgctctca acatgggctt ccgaggcagc
      361 gtttgagaag accttagcaa ggaacaccaa gcagtagtgg ctgaaacacc tcactccagg
      421 aaatgaaaca gtaacatggc agtacctgtt tgagaggatt aaaaccccaa aagactccat
      481 ttagaaaggg acaatgtcca aaaaaggacg aaataagggc gagaagcccg aggcactcat
      541 tgttgccctt caagctgcca atgaagacct caggaccaaa ctcacagaca ttcagataga
      601 acttcatcaa gagaaatcca aggtatcaaa gcttgaaaga gagaagactc aagaagcaaa
      661 gaggattcgt gagctggagc agcgcaaaca cacagtcctg gtgacagagc ttaaagccaa
      721 gctccatgag gagaagatga aggagctgca ggctgtgagg gagaatctca tcaagcaaca
      781 tgagcaggaa atgtcaagga cagtgaaggt gcgggatgga gagattcaga gactcaagtc
      841 cgctctgtgt gctctccgcg atggcagcag tgacaaagta aggacagcac tcaccattga
      901 ggcccgggag gaggccagga aacagttcga tgcagagcgc ctgaagctcc tgcaggaaat
      961 tacagactta aaaaccgcca agaagcaggt ggatgaggct ctgagcaata tgatccaagc
     1021 ggataaaatc aaggctgggg accttaggag tgagcatcag tcccaccagg aagccatctc
     1081 gaagatcaag tgggaatcgg aacgggatat acgaaggctg atggatgaaa tcaaagccaa
     1141 ggacaggatc atcttctccc tggaaaaaga actggagact cagacaggct atgtacagaa
     1201 actccagcta cagaaagagg ctttggatga gcagctcttc cttgtcaagg aggcagagtg
     1261 taacatgagc agtccgaaga gagagattcc aggaagggca ggggatggct ctgaacactg
     1321 cagcagcccg gatttgcgaa gaaatcaaaa gagaatagcc gaattgaatg ccactatacg
     1381 aaagttagaa gacaggaaca ccttgctcgg agatgaacga aacgagttgt taaaacgtgt
     1441 gcgggaaact gaaaaacaat gcaaacctct cctggaaagg aacaagtgcc tagccaagag
     1501 aaacgatgaa ctgatggtat ctctacaacg catggaagag aaattaaaag ccataaccaa
     1561 ggaaaattca gagatgagag agaaaataac gtctcaccca ccattgaaga aactgaagtc
     1621 tctgaatgac cttgatcaag ctaatgaaga acaagagacg gagtttctaa aactgcaggt
     1681 cattgagcag cagaacatca ttgatgagct caccagggat cgagaaaaac tcatccgtag
     1741 gagaaagcac aggagaagct cgaaaccaat caagaggcct gttttagatc cgttcattgg
     1801 ctatgatgag gattcgatgg attcagaaac atcatccatg acctccttta gaacagaccg
     1861 gacacctgct accccggatg atgacttgga tgaaagtcta gctgctgaag aatctgagct
     1921 acgatttcga caattaacaa aagaatacca agccctccaa agagcatatg ccctcttgca
     1981 ggaacagact ggaggcatca tagatgctga aagagaagcc aaggcacaag agcagctcca
     2041 ggcagaggtg ctgaggtaca gggccaaaat cgaagatttg gaagcaacgc tggctcagaa
     2101 agggcagata gagaagcagg aagcagagaa tcaccggcta cagcaagaac ttcaggatgc
     2161 cagagaccag aatgagctgc tggagtttcg caacctagaa ctagaagaga gagagaggcg
     2221 atcccctcca ttcaatctac aaattcaccc cttctcagat ggtgtgagtg cactgcagat
     2281 ctactgcatg aaagaaggtg tcaaggatgt caacatccct gatctcataa agcagcttga
     2341 tatccttggt gacaacggga atctaaggaa tgaagaacag gtggccataa ttcaggccag
     2401 cactgtgctg tccctggcag agaagtggat ccaacaaatt gaaggagcag aggctgccct
     2461 gcaccagaaa atgatggaac tggaaagtga tatggaacaa ttctgtaaaa tcaaaggcta
     2521 cctggaggaa gaactagact acagaaaaca ggctcttgac caggcatata tgagaatcca
     2581 ggaactagaa gctactttgt acaatgctct gcagcaagaa actgtgatca agttcggtga
     2641 actgttaagt gacaagcagc aagaggagtt gaggacggct gtagaaaagt tacggcggca
     2701 aatgctgagg aagagccggg aatatgactg tcagatcctc caggagagga tggagctcct
     2761 acagcaagct caccagagga tccgtgacct agaagataaa acagacatcc aaaaacggca
     2821 gataaaggac ctagaagaaa agtttctgtt tctattcttg ttcttctctc ttgccttcat
     2881 tctatggcct tgatgtcaag gtgcctctta aagaaaaatc aagaacttgg atcatacccc
     2941 aagaaggcaa atgcttttaa accttcaaag atggcaaaat tgtttacacc gatgtaaggg
     3001 aaatcaaaag ctaagaatta ccctgtagcc aagactatga gctttaaagc cattattcaa
     3061 ggtttcttac ttgacagttt ataatgaccc tgttgaaaaa tctacattat atgctgcaat
     3121 taatgaaacg tgtgtatgtc aaaccggaag agaactataa acatatattg tgggaaggaa
     3181 aatttcagca gtggaaccag tttcagcaga tcaaaagaag atgtgtcttg ggcatggaac
     3241 caaagttaca atgaaccatt caactcctgc tgtgcagggg gggtcatttt aatgtaacac
     3301 cacaccccat ggaaacacta ttcctgaaaa taaacatcat tttaaaaaaa aacaaaacaa
     3361 acaaaagtga aaaaaaaacc aacttaaggg tgggcgggta atgaagcacg aggaataata
     3421 cctatgagga actatttaca ataaaatgtt tcatttgaaa agtctggttt cttactacag
     3481 ggatttgctt ttctgtcttt atgattgttt taaactcagg aacagagaca tctatgatga
     3541 ggagggaaga aaaatactct ccattttgtt tctccaaaag gtggagttgg ggatgagaag
     3601 tggattctag ttactctaca agcgcagagc caagggactc tgaggagttt aacatggagt
     3661 ggaattggaa atctatgctt cctcatatca cacacctgca tctctccacc atggatggac
     3721 tggtctcctc cgtactgaac aaggtgaaaa ttatactcag aagtcacaaa ccgcctaact
     3781 tagctctgtc gaaaacatca agatctatag ggaactaggg ccaggaagca actctgcagc
     3841 ttccagattc aagttaaaat tgcctgcaga tgaatatgct gtctgacttg tgtgaagacc
     3901 ccacagaaat gatgagaagc tgacaactga acgtggggtt cccagagagc tgcgcatgtt
     3961 gagtatccca gagcaatctg aactcttgtc acttagaaca atagcattat tttctgagat
     4021 cgctgtccgc aacaagacgt ctctactttt ttatagacaa cactgacaag ctggttctct
     4081 atcacaggca gatagacaac taacactttt cctaagtcac atattacaga gtattggttt
     4141 cagcaatggc agtaaatata tcctcctgaa aagctgattt tacacgtcct tgactgtaga
     4201 taacaaggca acctcaattt ctcaaatact caatgttttc tttccaggtt tagaaatccc
     4261 atgcatcgag aatgtgtgta gggagccagg aactctttct atgaaatgct acacaaacag
     4321 gtccatatgt gaattgagta tattctcctt cagttttaac actggcaatt tcaaagccag
     4381 agcaactgaa gaatcttcaa gacaaaacag attcctgggg tcccacattt ttgtccttgt
     4441 atttaatgct gacccaactg tttggcccag tcactgaacc tctctgtgcc tcagtttcct
     4501 catctaaaaa aatggggatt aaatgttttg atttttttcc taaggttttg tttgcaattc
     4561 tggaacaaga ggtgcttaag gtagcacaaa gtgctttgta accgttataa atgctgtatt
     4621 atttgacttc cctgtataat gaaatagttc ctgagtttga ttcaaacagc agagcatcac
     4681 tgaagcgtcc ccatcaagct gcctaggaca ttattagcaa taaattgtga gattcaaaaa
     4741 ccacaatatt gaatctatag gaaatagatt gactcgttct attgagaaag acagaaagtg
     4801 tgtcatttca atgctaagca cctcccatgc tctcctgatt gcataacatg ccatcaatcg
     4861 aaacccccaa catcatcaca ggagagccaa ccatgcaact acggattgcc aagaacagaa
     4921 agcaacaaag aaagccgata ttatttttca aagaatgtca gatgatgtgt cctaatgcaa
     4981 aaactttaaa agtcagaact gtactaatgg attctttgta caactaaggt aagtcccaga
     5041 tccccgcaat tagcaggttc attgtgcagg tgatgtgaaa cagggtactt ctcctacacc
     5101 ggccacccag ctaactcagt cctgtatggg agtacacaaa cggcttgttt actgcttcaa
     5161 ttatacttca cctactatta taggacccac ttgagaaaat gcatacttaa tctgctccgt
     5221 acatgccttc ctcctctcct tttgcttttc ctatcgaaaa cctggtgggt aaattttcat
     5281 atcagagaac tatgtctaaa ttattatgaa tgccaataat atgctatatg ttaccctgtt
     5341 gttagtcaaa ttgcataaaa cccatgctga actttctgag agcgaaagcc acttgagtaa
     5401 tcatctctga aactttgatt ggtgggaggg ggaggctttc tttctgttta atatccagaa
     5461 tatcactcta gatcgtaagc taaatgatga catctttatc aggtgttcgt catagtcctc
     5521 aaaatgagtg ctctaatatt tagactagga aagtttaaat attttgatag agtccatatc
     5581 tacgatgaca gcatcaagaa aaactggagg tgtgcgtttt gcttattcac agatgcctga
     5641 gaatggtttc tatcttagtg aatgcttcct tgcatatgat gctcagaata gccaaaagaa
     5701 tgtactatta gtaacaaaga gttgtgctgt gacatcgttt ctcattttca aaagaaaaaa
     5761 aaggtaattc ctactccagg ttttaaattt tggtatctgt acttagctag agatttgggg
     5821 ggatgggcac aataagagta cacctaacta ctttttctta gccatgtact catctctctg
     5881 aatcccactg aagtagtttg agaggtgaaa gcttaacact gtcaggactt ctcagatttc
     5941 cataaaagaa atgcacagac tctatatgat atccattcta caaaacaagg tcagcaactt
     6001 cagcatcttg tcttaaatgc catctaactt atttcagttg aaaaattaaa ttagcactgt
     6061 cagatcctgt ttgacttatg tcatattcgc taaattgctg ctaaaagtga ggttttaaca
     6121 ataaaagcat actttgtttt gctttttttt cccctacaat tcagaataag tttatatcaa
     6181 agtataaaat tcttcccaac gttcgagatg tgcatcatca ctggggtcag aaagggcctt
     6241 caattgccat agaagaaata aaatttgcca aatcatttgt gctgtggtat tttatttcaa
     6301 accgttgggg tgtttttttc tacttgaaat aaatctcacc aatttttctt ctgctgattt
     6361 attgctaact ttttctaaaa acacacaata aaatctgtat gtttataact taaatggaat
     6421 tgataagcac cttcttttaa aacaatgctt atcattttaa cttgcctggg ttttcattga
     6481 aagctgtaaa aagagcatct gttggttatg ttgatattta aataactaga ccatctctgc
     6541 gatgtcacat cagaatagat gaccagtgta ctcagtatta aagcatatag atgtgttctt
     6601 tttatttgtc aaagaacgga atggaatact ccctctccct ccccctctcc ctccccctct
     6661 ccctccccct ctccctcccc ctctccctcc ccctctccct ccccctctcc ctccccctct
     6721 ccctccccct ctccctcccc ctccccctct ccctccccct cccccccctc tctctctctc
     6781 acacacacac acacacatac aatatgtgta ccaagacaag atttgtaaga ctcagctatg
     6841 ttgattggca gttgcattgc ttttgtgacg cttccactgc cctctctccc tcccccctcc
     6901 actcttccct cctgcttttt gttttctttt ttatactggt gctataggtt gaatccaggt
     6961 gcctgggcat tctagacagc acacagctgt atctccccag accccagccc tggtaattta
     7021 atatatttta gggattaaat ttgatctact atatggaaag tacataaatg taacttttga
     7081 agtataactt atgcaagtag ctcttagatg gctgtgccat ggtgttcagg atggatgcaa
     7141 agcccccttt ctgcttagat ggggaaaaga cataagataa agatttcctt attcccaact
     7201 gctttatact tttcatatag aatatgccta gagactagat tccatactta tatacaagag
     7261 gactttcaat gctggaagaa tggggttgtt cctcgggatg tcacttcaga actgagcaag
     7321 gcaggttttc ttcccatccc tgattttatc agttgagttc ctcctcaata aatctttatt
     7381 gctgagagag cctgagttga gttcttaatt tgacttttaa aagatacatg taaaggggca
     7441 gtacaggaaa gtggactgaa attcaccaca ttcactctag tgtgacaaac ctgtaattga
     7501 ttcactgaag ctttctggtt ttattttgct atttgatttt gtactgaaat ctttgttgta
     7561 taaagtccta cagggcggca atggtgcaga caaacaatgt tgagtcccct ttgcccacat
     7621 gaagactcta caaacttact aaagaatgaa tgatccaatc tctcaatcag aaacagatct
     7681 ggaacctgct ataaactgca gtcacttaag tttgacagac acctcacaaa acgtgcctat
     7741 ttcccctctt aactaaacca tctctcctga ataaggcaaa tcaaaatcta aacacttaat
     7801 aaatacaaga tgtacatagt catgcatatg tatcctgtac agagtatggt ggtgcaggca
     7861 ttaacagata tgtacttcag acctcgacag aagacttaga gatgatgctt ttctgatgtc
     7921 actaggcaac tcgattttgt ttggcgtata gtgtctatac ccacccctcc ttggctatat
     7981 ctctaccttc caccattact gctatttcct gttgcctgtg aattttccac gaccctgtcc
     8041 tctaagcaga acgttttgtt ccctagcatc tcaataaaac gcccagcaca atttacagta
     8101 ttaatatcaa tcaaaggtcc tatgcttttc tcaactaaaa ttgcatttcc agaagcttct
     8161 gtgcatgatc taacctatag tatttaattc tgtgaggatt tgagtttaca gggaacatat
     8221 ttgaatccac aattccttgt gtatctattg agttagtgta gccagggggc tggtttccaa
     8281 agcattccta cgattgcctg cattagttca ggtccttcct atcacagcat gactagtagg
     8341 ccacttcagt gcttactgat gagaggcaga acttgattga atgcagcaga gggattgtct
     8401 gaggttcacg ggacaggtac atgtgctgta tgtatcacca tagagatcgg aatccattta
     8461 ttgtatgtaa agttttatga acggttattt tataatttat gtatttaata tagcaatcaa
     8521 tgaactctgg tgttttagtt tctatgaaaa ataaaacaaa ctgcattttt taaaaaaaat
     8581 aaaagctttt accttgtgtt attcataa
//
LOCUS       NM_001437323            5072 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sarcalumenin (Srl), transcript variant 4, mRNA.
ACCESSION   NM_001437323 XM_063268900
VERSION     NM_001437323.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5072)
  AUTHORS   Zhao,X., Yoshida,M., Brotto,L., Takeshima,H., Weisleder,N.,
            Hirata,Y., Nosek,T.M., Ma,J. and Brotto,M.
  TITLE     Enhanced resistance to fatigue and altered calcium handling
            properties of sarcalumenin knockout mice
  JOURNAL   Physiol Genomics 23 (1), 72-78 (2005)
   PUBMED   15998745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063268900.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.25363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000010.1  11540449-11540519
            72-1364             JAXUCZ010000010.1  11566075-11567367
            1365-1466           JAXUCZ010000010.1  11570085-11570186
            1467-1562           JAXUCZ010000010.1  11572156-11572251
            1563-1598           JAXUCZ010000010.1  11574315-11574350
            1599-1715           JAXUCZ010000010.1  11576819-11576935
            1716-1949           JAXUCZ010000010.1  11578034-11578267
            1950-5072           JAXUCZ010000010.1  11581384-11584506
FEATURES             Location/Qualifiers
     source          1..5072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5072
                     /gene="Srl"
                     /note="sarcalumenin"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
     exon            1..71
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2761
                     /gene="Srl"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="sarcalumenin isoform 4 precursor"
                     /protein_id="NP_001424252.1"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
                     /translation="MKALLLLCCFLASLLLSGQAELQVSASGGTEDVGNLLENHFSAG
                     DASLEEKERALYADAAPGDKNLLLHYPDGREAESFEQPPAGAPSTANGQGSESEASLS
                     NSSAAESAPPGDVEGPGEEEEGPHAAGTLPPGGAEGPEERPEFSSGEEAGQEEAGVGL
                     PTEGAANMEAEAQEELQGRLGDGPMEEAAAGAAEPVAPQSTEGEEAEGEGSIGSDHQS
                     TELDGAQDAIPAGEDSDADVAAEAREEAEDQPEDHSLPSEDAAPPGPDHQPTDPHAVS
                     DMASSEVGAEEDAEDSKAEVDAETGEEAEDQGEPRPSLEAGSAREASEKSEDTQSSEV
                     RETEGQASGMSEEDLAEASSEEEGGEEDGRENGGLPSKEESGEDSGDGASSEEEGSTS
                     GEAAEPQKTPRATGHEEEGAQLDVEDLNTGSEGVKTQDTEAEASEERQQGRGNPVIAH
                     QEEAEDVSEEAPMRDRSHIEKTLMLNEDKPADDYSAVLQRLRKIYHTSIKPLEQSYKY
                     NELRQHEITVLGMAPRALSILDGEITSKPMVLFLGPWSVGKSTMINYLLGLEDTRYQL
                     YTGAEPTTSEFTVLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHK
                     LLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEML
                     FRQLKGRESQIRIILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQD
                     YKPDTHRDLFLKEEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYK
                     DKMTFFSDGELVFKDIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISNF
                     KLLSQQCSYMGGCFLEKIERAITQELPSLLGSIGLGKNPGAPNCDKTGCGETPKNRYK
                     KH"
     sig_peptide     11..70
                     /gene="Srl"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <236..937
                     /gene="Srl"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <236..937
                     /gene="Srl"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <821..>1459
                     /gene="Srl"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    <821..>1459
                     /gene="Srl"
                     /note="K+-dependent Na+/Ca+ exchanger; Region: 2A1904;
                     TIGR00927"
                     /db_xref="CDD:273344"
     misc_feature    1478..1561
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    1478..1561
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    1622..2347
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    1622..2347
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    1637..1660
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1637..1660
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1652..1663,1907..1909,2105..2107,2111..2113,
                     2213..2221)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    order(1652..1663,1907..1909,2105..2107,2111..2113,
                     2213..2221)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    1730..1732
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1730..1732
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1742..1750
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    1742..1750
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    1907..1918
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1907..1918
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1913..1918,1994..1999)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(1913..1918,1994..1999)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    2102..2113
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2102..2113
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2213..2221
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    2213..2221
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     exon            72..1364
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1466
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1562
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1598
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1715
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1949
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..5072
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtcacc atgaaggcgc tgctcctgct ctgctgcttc ctggcctcgc tgctgctttc
       61 aggacaagca gaactgcaag tctctgcttc gggtggcacg gaagatgttg gcaatttgtt
      121 ggagaatcat ttctctgctg gagacgcaag tctagaggag aaagaaaggg cgctttatgc
      181 agatgcggcc cctggagaca agaacctact ccttcactac ccagacggca gggaggctga
      241 gagcttcgag cagcctcctg caggggcccc ttccactgcc aacggccagg gctccgaatc
      301 cgaagctagc ctgtccaatt cctcagctgc agagtcagct ccacccgggg atgtcgaagg
      361 gcccggggag gaagaggagg gcccacatgc agcaggcacc cttcctccgg gaggggctga
      421 ggggccagaa gagaggccag agttcagttc tggagaggaa gcaggacagg aggaggctgg
      481 ggtggggctc cccacagagg gggctgcgaa tatggaggca gaagcacaag aggaattgca
      541 ggggcgctta ggagatgggc ctatggaaga agcagcagcc ggggcagcag agcctgtagc
      601 tccccagtcc acagagggtg aagaggcaga aggtgagggc agcataggct ctgatcacca
      661 atccacagag ctagatggag cccaggatgc catacccgct ggagaggact cagacgctga
      721 cgtggctgcc gaagccaggg aggaggcaga ggaccagccc gaggaccact ccctgccgtc
      781 agaggatgcc gcacccccag ggcctgatca ccagcccaca gacccacacg cagtctctga
      841 catggcatct tccgaagtag gggcagagga agacgctgaa gactcaaagg ctgaggtgga
      901 tgcagaaact ggggaggagg ctgaggacca gggggagcct agacctagcc tggaggctgg
      961 ctcagctaga gaggccagtg aaaagtccga ggacacccag agttccgagg tgagggagac
     1021 agagggccag gcatcaggga tgtcggagga ggacctggct gaggcctcct ctgaagaaga
     1081 gggcggtgaa gaagatggaa gggagaatgg aggacttcca tctaaagaag agtctggaga
     1141 agacagtggt gacggagcta gctcagaaga agaggggagc acctccgggg aggctgcaga
     1201 gccccagaaa acaccaagag ccacaggaca tgaggaggaa ggggcccagc ttgatgtgga
     1261 agatttgaac acagggtccg agggcgtcaa gacccaggac acagaagcag aggcatctga
     1321 agagagacaa caggggagag ggaatcctgt aattgctcat caggaagagg cggaggatgt
     1381 gagcgaagag gctcccatga gggatcgctc ccacatcgag aaaaccctga tgctgaatga
     1441 ggacaagcca gcggacgatt actcagcggt gctgcagcgg cttcggaaga tctaccacac
     1501 atccatcaag cccctggagc agtcttacaa gtacaatgaa cttcgacagc atgagatcac
     1561 agttctgggg atggcaccca gggccttgag catcctagac ggggagatta cttccaagcc
     1621 aatggtgctg ttcctgggac cgtggagcgt tggcaaatcc accatgataa actacctcct
     1681 tggattagaa gatactcgat accagcttta tacaggtgct gaacctacca cctctgagtt
     1741 cactgtcctc atgcatgggc ccaagctgaa aaccattgag ggcatcgtca tggctgctga
     1801 cagtgcccgg tccttctcac cactggaaaa gtttggccag aattttctgg agaagctgat
     1861 tggcattgag gttccccaca agcttctaga acgagtcact ttcgtggata ctccgggcat
     1921 cattgagaac cgcaagcaac aagaaagagg ttaccccttc aacgatgtgt gtcagtggtt
     1981 catcgacaga gccgacctca tcttcgttgt ctttgatccc accaagctgg acgtgggcct
     2041 ggagctggag atgctcttcc gacaactaaa aggacgcgag tcccagataa ggatcatttt
     2101 gaacaaggct gacaacctgg ccacacaaat gctcatgcgg gtgtatgggg ctctcttctg
     2161 gagcttggcc cctctcatca atgtcacgga gcctccccgg gtttacgtca gctccttctg
     2221 gccacaggac tataagcccg atacccaccg ggatctgttc ctcaaagaag agatctctct
     2281 cctggaagac ctgaaccagg tgatagagaa caggctcgag aacaagattg cttttattcg
     2341 ccagcacgcc atcagggtcc gaatccacgc ccttttagtt gaccgctatc tgcagactta
     2401 caaggacaaa atgaccttct tcagtgacgg ggaactggtc tttaaggaca ttgtggaaga
     2461 tcctgataaa ttctacatct tcaagaccat cctggcaaag accaatgtca gcaagtttga
     2521 ccttcccaac cgtgaggctt ataaggactt ctttggcatc aaccccattt ccaatttcaa
     2581 actcctctct cagcagtgct cctacatggg gggctgcttc ctggagaaga ttgaacgagc
     2641 catcacccag gagctcccca gccttctggg tagcattggg cttgggaaga atccaggtgc
     2701 tcctaactgt gacaaaacag gctgtggaga gaccccaaag aatcgctaca agaagcacta
     2761 gtttctgcgt agctatcctc gggtccccgt tggtgaataa gcttgcgtcc taactgtctg
     2821 agaagtcctg gtttgttaac cctttgagcc atactggcga caaccagtct gcattggaga
     2881 tttggaagtt cactgaggcc ggtgaatcag ggaaggcaca gggttctagg gaggagagcg
     2941 gtaactgtga atcatagtgt gcttgtccta ctgcttcagt tagaaggcct gacacaggcc
     3001 aagtcagtct acaaagcttc ccttgttttt tctgggtcct gtcttggaag ggcagagagc
     3061 agctaaatcc taatgaatac taagatagtg aggttctaat aagctaaact catggaaatt
     3121 tcctgagtaa cagaggcttc tcaggtctgt gtcaactcct ttcacacacg tcttctgttt
     3181 gatccctgtc cctccttggc tccctcctaa gcttgggttg attttcagaa gtggacagtc
     3241 tcttgagttt gatcttcatg aattttgagc ctaaccttgg aatcctctcc cagttttctc
     3301 aaggggcggg gcatccataa acctaaaaca agagttttta aattagggtg ttgatctgcc
     3361 gccactggtg tcccaattgg ggatctcaga cagttgtccc taaaaggagg gtgagtgggt
     3421 gatgtactca agtaccttcc cctccttaca cggaggtatg aagggctccg ggggttaatt
     3481 ggtttgcagt gtgtctttgt ctgttgcatg tcttggaaag ctcagatcac agaggtgttg
     3541 ggtttcagag tggacaatgg agaccttgct cctagtcctt agagggttct ctggacagac
     3601 attctcccaa gttttggtgg aagctgtttc tacagcttct ttgtgggagc acttgacaga
     3661 ggacttgcct cctctggttc ccagaaccat ggtttctctt ttcctttctt ctccattccc
     3721 tgatgcatca atacttccaa ctgagaaaaa gtccctcgga tcagaaccag taccagcccc
     3781 ttgacattgg cattggtgcc agataaggcc tgaggttaga ttcaaactga attcctgcag
     3841 atacccaccg agtgcagtca ggactgtcaa ggccttcaaa caccagtgaa tgtgcactta
     3901 gtgtgtccac tgtacaagag acagcccgga ggatgacaga tttgagggca cagagagagg
     3961 actcctggga gtcgtgcaag gcacacatac actgccacct tgaagtgcag gagagcaaga
     4021 cgctctggaa gggtgaagag ctttttgatg gagcaggcaa ggtgaagttc agcctgcctt
     4081 gagggcttcc tctgggcaca gccagctgct ttcgttttgg agcaacctct cctggaggcc
     4141 ttgattgtga ggcatgggtt gggatccagc agcagcaggg tgtcatctgg agcagaaggg
     4201 aagtgggagg gaaggctgag ccaacgttat tctttctgag gatcaaatat gcagcgtaag
     4261 catattggta accgaggagg ctacacagag aacatcaact gaggggtttg tgtttctccg
     4321 aattctttga agtctggtgc cttctaagga aggctgctgt tttggctcct cgtagggccc
     4381 aggacctgct gccgtaagtc aaaagctcca gaactgccag gacagtgtct ccaaggaatg
     4441 agttcctccc ataagggtca ttcatggagc ttggtggcta gggtagatga gctgcaatct
     4501 gtcttgggtt tttcttccca aactcctccc ctcttctctc catcatgcgc tctctggaga
     4561 gactgtccct cccacccttc tccttcctgc ccctcatgcc tgtgagtttt gtgtggcaaa
     4621 tctgtttttc tctcaatgca gaaacggggg aaaaagctga actgtatgga gcctgtccta
     4681 gctgtcagtg cctgcatgct tcgggggaag caggtgaaat gaggccaatg aattcttaca
     4741 gcatttgcgt ttggggggag gcacctgact agtggtacct tccttccttt tggatttctc
     4801 tccatccatt tcttctctgc ctccattctg tctctctccc actcacaggc cgctgacagt
     4861 cccacagctt tcagcactca atctttgcct ggccgtgcag agctgggttt tgagcaggat
     4921 tctgactagg aggagggaaa aacgtgggat gcagagattt cctgagggga acatctgtgt
     4981 ctgtgcctga agagtggctg acctttccag tgtcctttct attctgattt catcagggag
     5041 aacgtctcaa taaagttcca atctctcttc aa
//
LOCUS       NM_001437256            1644 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17),
            transcript variant 3, mRNA.
ACCESSION   NM_001437256 XM_063271165
VERSION     NM_001437256.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271165.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.848498.1,
                                           SRR26643429.43019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-873               JAXUCZ010000012.1  32587008-32587880   c
            874-1013            JAXUCZ010000012.1  32586490-32586629   c
            1014-1644           JAXUCZ010000012.1  32584816-32585446   c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1644
                     /gene="Mrps17"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
     exon            1..873
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    858..860
                     /gene="Mrps17"
                     /note="upstream in-frame stop codon"
     exon            874..1013
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     CDS             891..1274
                     /gene="Mrps17"
                     /note="28S ribosomal protein S17, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_001424185.1"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
                     /translation="MSIVRSAVHAKWVVGKVIGTAMVKTAKVRATRLVLDPYLLKYFN
                     KRKTYFAHDALQQCSVGDIVLLRALPVPRAKHVKHELAEIIFKVGRVIDPVTGKPCAG
                     TAYLESPLSSEATPPCESREELKSS"
     misc_feature    921..1142
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     misc_feature    921..1142
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     exon            1014..1644
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgcc caggctcctc cggccttggt ccgagttgta ggttttggag gtgagcgagg
       61 gctacggatc tgggtattgg gttcggcagt gctacgtctc ctgttactct ccctggtggt
      121 ttcggtagca aatgattccc aaagcggctc cgagtcaaag tctcgttgtt cctgtacagg
      181 aagctggctg accggccgag gtcttgcagt gagctcttgt gtgtgtggta gcgggctgta
      241 ttgtctataa ttgagacaga gaactgcaat aaatgctgtg acctcgagaa cgtgccctgc
      301 taacgacaag aaataaacct cgcagactcg ggagttgagc gcttcaaaca gcatcgttta
      361 ttataatact ccctaattgg gaaccagttc caagaaagga caccaagtga cacggacgag
      421 gtgtttctaa atggttacag aataaagaat agtgggtaaa gggtaaataa ggtgacttgt
      481 agtgatctag taggcacctg taggtagaag agctttggtc tgtagagcat ctgtgatcgg
      541 tagcagggga attttccgga tgattaggtt agagccgcac tgaggcggga cccttaactg
      601 tttattttcc cgctgtatcc ttcctcattt ggagagaggg acgccagtgt gaccagttta
      661 attgtgtgct tgcacactaa tagttcctca aaacaccttt actcaggcca tgttattcct
      721 aactttctgt atagggaatc tgaaggttaa attcattttc tactttgtaa acattataaa
      781 gataagtcct gtaagcatct ttaaccaggc tgtttcagaa aagtagaaaa atgactgctg
      841 gacacgggca ttgctcctaa cgaaattctc ttggcgctca cagacacata atgtcaatag
      901 tccgttcagc cgtccacgcc aaatgggttg tggggaaggt gattggtaca gcaatggtaa
      961 aaactgctaa agtaagagcg accagacttg ttttggatcc ctacttacta aagtacttta
     1021 ataagcggaa aacctacttt gctcatgacg cccttcagca gtgcagcgtc ggggacatcg
     1081 tgctcctcag agctctgccc gtcccacgag caaagcacgt gaaacacgaa ctggcagaga
     1141 tcatcttcaa agtgggccga gttatcgacc ccgtcacagg aaagccctgt gcaggaaccg
     1201 cctacctgga gagccccctc agttcagaag ccactccccc ctgcgaatct cgagaagagc
     1261 tcaagtcctc ctgaacctgg ggaagaggga gccagaggat ggatgtctgt ctgtttgctc
     1321 agtggctttt catactgttt ctcctgtgac attagaagta ttcaacagag taaagagctt
     1381 agcgttccat aaaggttcgc atcctttttc agattctctg ccctgaagtt accttccgag
     1441 tactctgtat gcctaagcgt gctgcgtcat tccgtaagct cactgtccta gatcatatat
     1501 gtattgtttt gtttgccatc actcaaagaa atcttggact ttgcaccttt attttaaaag
     1561 aagaaaacct tttgataata acagaaaagg ctaaacttag tttcgatagc tgaatttttc
     1621 aaaatatatc gtgtgtgtcc acaa
//
LOCUS       NM_001105916            2940 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            1, mRNA.
ACCESSION   NM_001105916 XM_001068938 XM_222022
VERSION     NM_001105916.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2940)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2940)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2940)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2940)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001105916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.34953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000012.1  24761245-24761362   c
            119-165             JAXUCZ010000012.1  24761121-24761167   c
            166-219             JAXUCZ010000012.1  24760247-24760300   c
            220-466             JAXUCZ010000012.1  24759745-24759991   c
            467-644             JAXUCZ010000012.1  24759477-24759654   c
            645-785             JAXUCZ010000012.1  24756632-24756772   c
            786-897             JAXUCZ010000012.1  24756440-24756551   c
            898-1020            JAXUCZ010000012.1  24756223-24756345   c
            1021-1137           JAXUCZ010000012.1  24754191-24754307   c
            1138-1277           JAXUCZ010000012.1  24753946-24754085   c
            1278-1441           JAXUCZ010000012.1  24752946-24753109   c
            1442-1561           JAXUCZ010000012.1  24751630-24751749   c
            1562-1644           JAXUCZ010000012.1  24749484-24749566   c
            1645-1708           JAXUCZ010000012.1  24749332-24749395   c
            1709-1776           JAXUCZ010000012.1  24749165-24749232   c
            1777-1853           JAXUCZ010000012.1  24749003-24749079   c
            1854-1938           JAXUCZ010000012.1  24748839-24748923   c
            1939-2166           JAXUCZ010000012.1  24748522-24748749   c
            2167-2307           JAXUCZ010000012.1  24748072-24748212   c
            2308-2940           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2940
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..118
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    85..87
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="upstream in-frame stop codon"
     exon            119..165
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..219
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2583
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001099386.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    253..264
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    259..318
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    430..492
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    601..>762
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    601..>762
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    802..1374
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    802..1374
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    889..891
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(1078..1080,1120..1131,1135..1137,1147..1158,
                     1165..1167,1171..1179)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1078..1080,1120..1131,1135..1137,1147..1158,
                     1165..1167,1171..1179)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1150..1152,1168..1170)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1150..1152,1168..1170)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1165..1167,1174..1176)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1165..1167,1174..1176)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1177..1179,1183..1185,1195..1200)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1177..1179,1183..1185,1195..1200)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1186..1188
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1396..2097
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1396..2097
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1417..1419,1423..1425,1432..1434,1438..1443,
                     1447..1449,1579..1581,1585..1587,1636..1638,1645..1671)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1417..1419,1423..1425,1432..1434,1438..1443,
                     1447..1449,1579..1581,1585..1587,1636..1638,1645..1671)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1789..1791
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2176..2550
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2176..2550
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            220..466
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..644
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..785
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..897
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1020
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1137
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1277
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1441
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1561
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1644
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1708
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1776
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1853
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1938
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2166
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2307
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2940
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acaggcacga ggcagggact ggggtgagcc cctacctctc agatctttct ggacctggct
      121 gcgggtcctg ggatcttcag cgcggcttgg atttcaaact ggaggggttc aggagggggc
      181 acaagcatgg aacaacgttg gggtctactt cggaaagtgc aacagtggtc cccaagaccc
      241 tctcagacca tctacagacg tgtggaaggc cctcaactgg agaacctaga ggaggaagat
      301 agggaggaag gggaggagct tcctgcccag ttctgcccca tggaactcaa aggccctgag
      361 cgcttaggct cctgtcctgg gaggtccatt cccataccct gggctgcagc aggtcgaaag
      421 gctgctccct atctggtcct gaccaccctg ctaatcttca ctggggcctt cctcctgggc
      481 tacgtggcct ttcgagggtc ctgccaggca tgtggggact ctgtgttggt ggttggtgaa
      541 gatgtcaact ctgaggactc cagccggggc acgttgtact ggagtgacct ccaggacatg
      601 tttctccggt tccttgggga gggacgcatg gaggacacca tcaggctgac cagcctccgg
      661 gaacgcgtgg ccggctcagc cagaatggcc accctggtcc aagacatcct cgataagctc
      721 tcgcgccaga agctggacca cgtgtggact gacacgcact atgtgggact tcagttcccg
      781 gacccggctc accctaacac cctgcactgg gtgggtgcag acgggagcgt ccaagagcag
      841 ctaccgctgg aggatccgga agtctactgt ccctacagcg ccacgggcaa cgccacgggc
      901 aagcttgtgt acgcccacta cgggcggcgg gaggacctgc aggacctgaa agccaaggac
      961 gtggagctgg ccggcagcct cctgctagtg cgtgctggga ttacaagctt cgcccagaag
     1021 gtagccattg cccaggactt tggggcccac ggagtgctga tataccctga cccagcggac
     1081 ttctcccaag acccccacaa gccaggcctg tctagtgaca gggctgtgta tggacatgtg
     1141 cacctgggaa ctggggaccc ttacacgcct ggcttcccgt ccttcaatca aacccagttc
     1201 cctccagtag aatcatcggg gcttcccaac atccctgccc agcccatcag tgccgacgtt
     1261 gctgatcgct tgctcaggaa actcacaggt cccgtggctc ctcaggaatg gaagggtcgc
     1321 ctctcagact ctccgtatcg cctgggacct gggccaggct tacgccttgt ggtcaacaac
     1381 cacagaacct ctactcccat cagtaacatc tttgcgtgca tcgagggctt cgcagagcca
     1441 gatcactatg tcgttatcgg ggcccagagg gatgcctggg gcccaggagc agccaagtct
     1501 gcagtgggga ctgccatcct cctggagctg gttcggacct tttcctccat ggtcagcagt
     1561 ggctttagac ctcgaagaag tcttttgttc atcagctggg acggaggtga ctttggcagc
     1621 gtgggagcca cggagtggtt ggagggctac ctcagcgtgc tacacctcaa agctgtcgtg
     1681 tatgtgagcc tggacaactc cgtgttggga gacggcaaat tccatgctaa gaccagcccc
     1741 cttctcgtca gcctcattga gaatatcctg aagcaggtgg attcccctaa ccacagtgga
     1801 cagacactct acgatcaagt ggcattcacc cacccaagct gggatgctga agtgatccag
     1861 cccctgccca tggacagcag cgcatattcc ttcacagctt ttgcgggcgt cccagctgtg
     1921 gagttctcct tcatggagga cgatagggtg tacccattcc tgcacacgaa ggaggacacg
     1981 tatgagaatc tgcacaagat gctgcgaggt cgcctgcccg ccgtggtcct agcagtggct
     2041 cagctcgctg gtcagctcct catccgactg agccacgatc acctactgcc gctggacttc
     2101 ggccgctacg gagacgtggt cctcaggcac atcggcaacc ttaatgagtt ctctggggac
     2161 ctcaaggcgc gcgggctgac cctgcagtgg gtgtactctg caagggggga ctatatccgg
     2221 gcggcggaga agctgcggaa ggagatttac agctcggagc agagcgatga gcgtctgatg
     2281 cgcatgtaca acgtgcgcat catgagggtg gagttctact tcctgtccca gtacgtgtcg
     2341 ccggccgact ccccattccg ccacattttc ctaggccaag gcgaccacac tttgggtgcc
     2401 ctggtggaac acctacggat gctgcgctcc gatggctcag gagctgcctc ttctgggttg
     2461 agcccaggtc tgggcttcca ggagagtcgc ttccggcgac agctggcgct gctcacgtgg
     2521 acgctacagg gggcagccaa cgcactcagt ggcgacgttt ggaacatcga caataacttt
     2581 tgaggccaga agtcctccat gggccccacg tgattctcct ttctccctat ttgagtggtg
     2641 caggcaacgg aggtgcctga gagcaaccta tcctcattaa caaccttggt cctgcaacgc
     2701 cagtgagaca tattttctca gtgtgactgt tataccactg tttatccaga aagcggtttt
     2761 cttcccatca ctggcctctc tgccttcagg agcatagttc cccatatcta gaaaccatct
     2821 agacactggg atccagctct cttagcgggt gagatggata gcgtcatttt cttatgacac
     2881 acaagtggta tgtgggtggc ccaaggggga ttagatgtca ataaaccatt tacctggtaa
//
LOCUS       NM_001437413            2942 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 5, mRNA.
ACCESSION   NM_001437413 XM_063285652
VERSION     NM_001437413.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063285652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2969352.1,
                                           SRR26643429.2897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000001.1  165852282-165852575
            295-469             JAXUCZ010000001.1  165857557-165857731
            470-611             JAXUCZ010000001.1  165859584-165859725
            612-790             JAXUCZ010000001.1  165864598-165864776
            791-876             JAXUCZ010000001.1  165866964-165867049
            877-1049            JAXUCZ010000001.1  165867251-165867423
            1050-1125           JAXUCZ010000001.1  165869240-165869315
            1126-1256           JAXUCZ010000001.1  165870275-165870405
            1257-2942           JAXUCZ010000001.1  165870906-165872591
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2942
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..294
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..469
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    404..406
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             425..1492
                     /gene="Xndc1"
                     /note="isoform 2 is encoded by transcript variant 5; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 2"
                     /protein_id="NP_001424342.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQ
                     LKVEFQLERAVPISYIDVDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSL
                     DSLSDPVKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALK
                     GMLKQLQPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRK
                     NNASRGKRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPIC
                     TGSFSIEALPRHAATCGESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICE
                     LQFSAREIEEHASVCGEVFPA"
     misc_feature    425..718
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    425..718
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            470..611
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..790
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..876
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1049
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1125
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1256
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2942
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgacc cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata
       61 tatattaaaa actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct
      121 gtacttcctc agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg
      181 ttttgggcta cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa
      241 taagatctga gcaccgaaac tgaagctact acgacatgaa gtttatggac gcgggagtaa
      301 tgtaaggact cttcttcttc caaaagctac caagagcaaa acatagaccg tgtcaccgtg
      361 gttacagaag acatcctggg aggaagcata tctgcctcgc aaataaagaa gctggtggcc
      421 tccgatggct cctgtgaaga tcagccatgt ggtgtcattt tcctctcagg atcccaaata
      481 tcctgtggag aacttgctga acccagacag tcataaggga ccttggctca gctgccctcg
      541 ggacaagact gggcaactga aagtggagtt tcagctggag agagcagtgc ccataagcta
      601 catcgatgtc gatgattttc tgattccagc ctcaggagaa tcatgggatc gacttcgatt
      661 gacctgctcc caacctttca cacgtcatca atcctttggc ctggccttcc tccgagtacg
      721 ttcctctctg gactctctgt ctgaccctgt aaaggatccc tcatcccctg ggagctctgg
      781 gcttaatcag aactcttctg ataagctgga gtctgatcct agcccctggc tgactaatcc
      841 ttctatccgg aggaccttct tcccagatcc ccagacgagc accaaggaaa tttcagcgct
      901 caagggtatg ttgaagcagt tgcagccagg gcctctgggg cgggcagccc gcatggtgct
      961 ttctgctgcc cataaggcac ctccagccag tgtcgtaagc ccaaacaata gccatggaga
     1021 accagattcc agtcatcccg agcgtgcaga gcccagagca gaagaaccaa acaggaagaa
     1081 caatgcaagc agagggaaga ggaggaaagt ccaggagcaa aggagaccgt tgtccagctc
     1141 aagctctcag ccaaatagga gggcaacagg aaggacaaag caaagacagc aacgacctca
     1201 ggccaaaagt gatggcagtg gtgtgcaggc tactggacag tgtcccattt gtacaggttc
     1261 cttcagtatt gaggctcttc cccggcatgc tgccacttgt ggagagagct ccccacccca
     1321 gccagcttct cctacctcct tgtcttcctc agagtctgtg ctgtgggtgt cttccccaga
     1381 gagctcgccg ccaccatctt cctgggtcca atgccctatt tgtgaattac agttctcggc
     1441 aagagaaata gaagaacatg ccagcgtgtg tggggaagtt tttccagcct gagcagtgac
     1501 attctgctaa ccctttcttg atgttggagc ctggggaatg gatctcttgt ggctaagaag
     1561 cattggtccc ctcccttctg tgattacctc aggactctgc ctgcctgagg acactttgga
     1621 cccagcttgc tccccattcc cgttgccaag gctgtgtcac tatggtaccc aattctcata
     1681 aggatatttt ccccttagaa catatttggt agaattgatg atctctccaa ggccttagaa
     1741 cactatctag aatgtgattt ccaatgccca tttccctgaa aggaaaacgg aggctcacct
     1801 agggggaaat actgcctgaa aattataaag tcctatgatg gtctgggaag atgagtgagt
     1861 cttgagcatg acactgacac tgagtcccat ctgaccttga ccttctatat ctttcatggg
     1921 tgtctgcccc aggtgtaatc agatactgcc ctgaaacttc acactactta ccataggtgt
     1981 ggaatggacg ttcagtgaca caaaaacccc tcacagggtt cttaaaggaa ccagagagat
     2041 ttccttctaa ggaataggcg tggctgtaaa agtttgagca aatctcgttc taactatttg
     2101 agatagttgg accatagtgt ctccccaagg tcccctggag ctgcgatggt ccaattctgc
     2161 tttgaagaat tatgcacgct tcccttttcc ccaggagatg tcttcatgtg gcactaacac
     2221 ccgtccccct tatccccaag gtacagggca gggagagagc agctggtcct ggtgaaggga
     2281 gggcttgggg tggggccttg agtgggaatg aaagagcatg tgagccgcag tcaagggaga
     2341 ggcagagcag gagttcaagc cttcagcccc tgcccacaga agtgggtgca gccatggatc
     2401 ccctttcggt aagagaccct tgcttccctc ccctcctcat cccagtcccc agggggatgc
     2461 agggacagcc tgctgctgtt ggtgggagag cccctggatt cctgatccag ggcctagaag
     2521 aaaagagcag ggagctggac ctggtagaac aggacgcaac agtaccaagg aggggagatg
     2581 ctctccaagg tagaaggcag agtgagagta tccggtggag ggaaagcacc ttaaggtcct
     2641 actagagtct ttcatagaga aagggtttag ggaaagtgca gcttaaagac cctctgtgtg
     2701 ggcatgtctg aacttgtcct tcagagagat gagcagctac aagatgggaa ctggattcct
     2761 gtcggatgtg tataggttag gtgcctagtg cggccccaac cacctacttt aatcacctct
     2821 cttcagggaa ctaacttggg ccctgttatg tctgattttt ataagaatgg aagtgggctg
     2881 agtaaatact ccccatacta gcttttccta catgagtcta cataataaaa tggtgaacaa
     2941 ga
//
LOCUS       NM_001437237            3681 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 4, mRNA.
ACCESSION   NM_001437237 XM_063271161
VERSION     NM_001437237.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3681)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271161.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.84528.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000012.1  32093062-32093268   c
            208-272             JAXUCZ010000012.1  32090917-32090981   c
            273-367             JAXUCZ010000012.1  32090152-32090246   c
            368-545             JAXUCZ010000012.1  32079959-32080136   c
            546-831             JAXUCZ010000012.1  32077686-32077971   c
            832-982             JAXUCZ010000012.1  32072686-32072836   c
            983-1166            JAXUCZ010000012.1  32071923-32072106   c
            1167-1310           JAXUCZ010000012.1  32070118-32070261   c
            1311-3681           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3681
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..207
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            208..272
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            273..367
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    357..359
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            368..545
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1331
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001424166.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    414..1157
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    414..1157
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    447..509
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    618..704
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    921..983
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1194..1256
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            546..831
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            832..982
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1166
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1310
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..3681
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatgatca cccactgccg gtgtggacac atcacatgct gtggttctca gtgatcacat
       61 aacgtgagcc tgtgtggaca cgtcacactg ctgttatttc ccgcacccat cttttttgtc
      121 aggcaccaaa gacttccttc cctctctaca cctggctgct acatgactaa ggaattacta
      181 gagcactttt ggtggggggt cttctagagc gctaggatta aaggcatgca aggcggaaga
      241 taccaggatc tccaaggaaa ttgcagataa agccacatct gtgaaggaaa ctcatgtcta
      301 agagcacccc gacctttgac actctaagga caggtggatg tgatctttac cacagatgac
      361 cctttcggtt gccgctggtg agaagcatgt tcagcattaa ccccttggag aacctgaagc
      421 tgtacatcag cagccggcca ccgttggtgg tttttatgat cagtgtcagc gccatggcca
      481 tcgccttcct caccctgggc tacttcttca agatcaagga gattaagtcc ccagaaatgg
      541 ctgaggattg gaatactttc ctgctccggt ttaatgattt ggacttgtgt gtatcagaaa
      601 atgagacact gaagcatctc tccaacgata ccaccacacc tgagagcacc atgaccatcg
      661 ggcaaaccag atcgtccacc cagccgcccc agtccctgga ggagtcaggc cccatcaata
      721 tttcagtggc cattaccttg accttggacc ctctcaagcc ctttggaggg tactctcgaa
      781 atgtcacaca cctgtactcc accatccttg gccatcagat tggattgtca ggcagggaag
      841 cccatgagga gatcaacatc accttcaccc tgcctgctgc ctggaatgcc gatgactgtg
      901 ctctccatgg ccactgtgag caggtggtgt tcacagcatg catgaccctc acagctgccc
      961 ctggagtctt ccctgtcacc gttcagccac ctcactgtgt ccccgacaca tacagcaacg
     1021 ccacactctg gtacaagatc ttcacaactg ccagagatgc caacacgaaa tacgctcaag
     1081 actacaaccc tttctggtgt tacaagggcg ccattgggaa agtctaccac gctttaaatc
     1141 ccaagctcac cgtcattgtc ccagatgacg accgctcctt aataaacctg catctcatgc
     1201 acaccagtta cttccttttc gtgatggtga taacgatgtt ctgctatgca gttatcaaag
     1261 gcagacccag caaactgcgg cagagcaatc ctgaattttg ccctgagaag gtggctttgg
     1321 ctgatgccta atcccacagc tccccatttt ctgagagacc aagaaccatg atcattgcct
     1381 gctgaatcgg ccagggcctg gccactctgt gaatacacga tcttgcaatg ttgggttatt
     1441 ccagccaaag acatttcaag tgcctgtaac tgatctgtac atatttataa acgttgatct
     1501 ggaaactggt cctgtggtgc acgtgctttg ccctggatgc ggccggaacc cgtcagcctc
     1561 actgaggggc aggagggcac tgacatgggg ttcttccatg aagtgccggg ggatgtggga
     1621 atcttgccag agctgagcgt gtcgtgttcc aacaccagcg gccgaggttg gctgcggttc
     1681 ttgtctcaga cgggggtgtg cagtgttgga cgctgtgtgc acctttgtca ggacactgtt
     1741 tcagaagcca ccattccctc ctgcggctct cacgtgtctc agtgaccata tagcgacagc
     1801 agtagttcct tctcagtttg cttgcaagga aactgttttt aaaagagaaa acaagctaca
     1861 ttttatattc cccttgttag gacagacagg cttgtctatc caggtcaaag gtcacgcccc
     1921 caaggcattt ctgtagtgaa gagcagagtt ccgtctccac actggcccct aggaactgga
     1981 gtgctttgct cctctgtgct cctggtagag aagttcctgg cttgagaagt ggcggtgtaa
     2041 tggggacaca gggcagcaca ggctgcctaa cttcacaagg cagaagagat ggcgggctgc
     2101 tgtaatgctc acaagcaggg cttgcttttt ttttctttct aaaattcgtt tcgcattcat
     2161 ttttgtacat cacacatcta tctccagaag gagaatgaac attataggta tataatgtgg
     2221 agctggtgca gggaagatct gaaggaagaa ggcgtatgag gcgctgatgg ctggccagtc
     2281 aaaaccagaa gcgttttcct taggacagtt gtgaccatcc ggccccagtg ccctctcgca
     2341 tttcctttag gaaagtcatt cgcattccct tctgcgagtt acttgtattt gcagtggttt
     2401 tctatcaatg ccttgcctta atgcccatgc agtgttcttc caggcagtgt tccagacttg
     2461 ctgggtgtga ggatgaatgc atgttaggag cagccctctg gaggccgagg gaggagaatc
     2521 tcgagtgcga ggctggcctg ggccacatac tgatagcctg tctcacagga agaaaaacta
     2581 cttaggtatg tcagcacttc tgtcccgtaa ctgtaggtct gtctcagttg cagttaactt
     2641 gctgtatccc gaaccttact ggcctagaga attttatccc aggcattctt agatggaaaa
     2701 caatactttg gatttttgtt ctaaattgaa gcttgtgaaa ataatcactg tagttaggtg
     2761 acgccctaat gttttttaaa gcagaggtga gttacttata agatggctaa tgtgtgaatt
     2821 tcatttagtc ttcccttaga ctttgagagc cttgtcaggc aggatggaga aaacccacgt
     2881 ggcttagctg gtatgaatgt gtcatcagga ccatcaagtt tcagattaag tagtaagacc
     2941 cagtagagta agacatgaga agaaatcacc ttcattggtc tgtcggctgt gttcctctta
     3001 gtcatccttg tgttaatgac aggcagtggc tgggatttgt agagggtggg aaggaggaac
     3061 accataagac ctggggagag gaagtcccca aaatgcttga gagtgaccca tcctgaggcc
     3121 agatacatat tttaaagccc aagtattcgc catagcaggt agacagatgg aggatggctg
     3181 gggaaggagg ttgtgggctg agtttagggg actgcagaca catctgggcc tggtcctcag
     3241 ctgctccttg gtggtaaacc tcaaaaatgg catgtcagat tggccactag agacctctga
     3301 ccccagcagc actggcttgt cctcaggtgt gggtgtgtca gaagtcagtg acttcctggg
     3361 aaatggttgt ttcggatcac attgatcttt ccttttgtct ttcaccgtat ggtaggactt
     3421 gaatcagttt tgattctgtg tgtacgttct cttcgtttgg aacctggcgt ttctgtctgt
     3481 tcttggcagt gcataggaac ccagcctcct gtattttgac cctcctgcag gcactgtggg
     3541 acccaagggt agcagatcca tctcccgtcc cttgctgcat gatggtcact agctgatctg
     3601 tgatggcatc cctccctcat tgattttctg tgtttgaagt atgtgcacat gtgctttaca
     3661 gaataaaaca tctggattta c
//
LOCUS       NM_001371781            3743 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sarcalumenin (Srl), transcript variant 2, mRNA.
ACCESSION   NM_001371781 XM_008767510
VERSION     NM_001371781.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Zhao,X., Yoshida,M., Brotto,L., Takeshima,H., Weisleder,N.,
            Hirata,Y., Nosek,T.M., Ma,J. and Brotto,M.
  TITLE     Enhanced resistance to fatigue and altered calcium handling
            properties of sarcalumenin knockout mice
  JOURNAL   Physiol Genomics 23 (1), 72-78 (2005)
   PUBMED   15998745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001371781.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.41574.1,
                                           SRR26643295.37072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000010.1  11540449-11540519
            72-173              JAXUCZ010000010.1  11570085-11570186
            174-269             JAXUCZ010000010.1  11572156-11572251
            270-386             JAXUCZ010000010.1  11576819-11576935
            387-620             JAXUCZ010000010.1  11578034-11578267
            621-3743            JAXUCZ010000010.1  11581384-11584506
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3743
                     /gene="Srl"
                     /note="sarcalumenin"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
     exon            1..71
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1432
                     /gene="Srl"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="sarcalumenin isoform 2 precursor"
                     /protein_id="NP_001358710.1"
                     /db_xref="GeneID:302948"
                     /db_xref="RGD:1306564"
                     /translation="MKALLLLCCFLASLLLSGQAEEAEDVSEEAPMRDRSHIEKTLML
                     NEDKPADDYSAVLQRLRKIYHTSIKPLEQSYKYNELRQHEITDGEITSKPMVLFLGPW
                     SVGKSTMINYLLGLEDTRYQLYTGAEPTTSEFTVLMHGPKLKTIEGIVMAADSARSFS
                     PLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRA
                     DLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADNLATQMLMRVYGALFWSL
                     APLINVTEPPRVYVSSFWPQDYKPDTHRDLFLKEEISLLEDLNQVIENRLENKIAFIR
                     QHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFKDIVEDPDKFYIFKTILAKTNVSK
                     FDLPNREAYKDFFGINPISNFKLLSQQCSYMGGCFLEKIERAITQELPSLLGSIGLGK
                     NPGAPNCDKTGCGETPKNRYKKH"
     sig_peptide     11..70
                     /gene="Srl"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    185..283
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    185..283
                     /gene="Srl"
                     /note="N-terminal EH-domain containing protein; Region:
                     EHD_N; pfam16880"
                     /db_xref="CDD:465295"
     misc_feature    293..1018
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    293..1018
                     /gene="Srl"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    308..331
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    308..331
                     /gene="Srl"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(323..334,578..580,776..778,782..784,884..892)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    order(323..334,578..580,776..778,782..784,884..892)
                     /gene="Srl"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    401..403
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    401..403
                     /gene="Srl"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    413..421
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    413..421
                     /gene="Srl"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    578..589
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    578..589
                     /gene="Srl"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(584..589,665..670)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(584..589,665..670)
                     /gene="Srl"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    773..784
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    773..784
                     /gene="Srl"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    884..892
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    884..892
                     /gene="Srl"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     exon            72..173
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            174..269
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            270..386
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            387..620
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
     exon            621..3743
                     /gene="Srl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagtcacc atgaaggcgc tgctcctgct ctgctgcttc ctggcctcgc tgctgctttc
       61 aggacaagca gaagaggcgg aggatgtgag cgaagaggct cccatgaggg atcgctccca
      121 catcgagaaa accctgatgc tgaatgagga caagccagcg gacgattact cagcggtgct
      181 gcagcggctt cggaagatct accacacatc catcaagccc ctggagcagt cttacaagta
      241 caatgaactt cgacagcatg agatcacaga cggggagatt acttccaagc caatggtgct
      301 gttcctggga ccgtggagcg ttggcaaatc caccatgata aactacctcc ttggattaga
      361 agatactcga taccagcttt atacaggtgc tgaacctacc acctctgagt tcactgtcct
      421 catgcatggg cccaagctga aaaccattga gggcatcgtc atggctgctg acagtgcccg
      481 gtccttctca ccactggaaa agtttggcca gaattttctg gagaagctga ttggcattga
      541 ggttccccac aagcttctag aacgagtcac tttcgtggat actccgggca tcattgagaa
      601 ccgcaagcaa caagaaagag gttacccctt caacgatgtg tgtcagtggt tcatcgacag
      661 agccgacctc atcttcgttg tctttgatcc caccaagctg gacgtgggcc tggagctgga
      721 gatgctcttc cgacaactaa aaggacgcga gtcccagata aggatcattt tgaacaaggc
      781 tgacaacctg gccacacaaa tgctcatgcg ggtgtatggg gctctcttct ggagcttggc
      841 ccctctcatc aatgtcacgg agcctccccg ggtttacgtc agctccttct ggccacagga
      901 ctataagccc gatacccacc gggatctgtt cctcaaagaa gagatctctc tcctggaaga
      961 cctgaaccag gtgatagaga acaggctcga gaacaagatt gcttttattc gccagcacgc
     1021 catcagggtc cgaatccacg cccttttagt tgaccgctat ctgcagactt acaaggacaa
     1081 aatgaccttc ttcagtgacg gggaactggt ctttaaggac attgtggaag atcctgataa
     1141 attctacatc ttcaagacca tcctggcaaa gaccaatgtc agcaagtttg accttcccaa
     1201 ccgtgaggct tataaggact tctttggcat caaccccatt tccaatttca aactcctctc
     1261 tcagcagtgc tcctacatgg ggggctgctt cctggagaag attgaacgag ccatcaccca
     1321 ggagctcccc agccttctgg gtagcattgg gcttgggaag aatccaggtg ctcctaactg
     1381 tgacaaaaca ggctgtggag agaccccaaa gaatcgctac aagaagcact agtttctgcg
     1441 tagctatcct cgggtccccg ttggtgaata agcttgcgtc ctaactgtct gagaagtcct
     1501 ggtttgttaa ccctttgagc catactggcg acaaccagtc tgcattggag atttggaagt
     1561 tcactgaggc cggtgaatca gggaaggcac agggttctag ggaggagagc ggtaactgtg
     1621 aatcatagtg tgcttgtcct actgcttcag ttagaaggcc tgacacaggc caagtcagtc
     1681 tacaaagctt cccttgtttt ttctgggtcc tgtcttggaa gggcagagag cagctaaatc
     1741 ctaatgaata ctaagatagt gaggttctaa taagctaaac tcatggaaat ttcctgagta
     1801 acagaggctt ctcaggtctg tgtcaactcc tttcacacac gtcttctgtt tgatccctgt
     1861 ccctccttgg ctccctccta agcttgggtt gattttcaga agtggacagt ctcttgagtt
     1921 tgatcttcat gaattttgag cctaaccttg gaatcctctc ccagttttct caaggggcgg
     1981 ggcatccata aacctaaaac aagagttttt aaattagggt gttgatctgc cgccactggt
     2041 gtcccaattg gggatctcag acagttgtcc ctaaaaggag ggtgagtggg tgatgtactc
     2101 aagtaccttc ccctccttac acggaggtat gaagggctcc gggggttaat tggtttgcag
     2161 tgtgtctttg tctgttgcat gtcttggaaa gctcagatca cagaggtgtt gggtttcaga
     2221 gtggacaatg gagaccttgc tcctagtcct tagagggttc tctggacaga cattctccca
     2281 agttttggtg gaagctgttt ctacagcttc tttgtgggag cacttgacag aggacttgcc
     2341 tcctctggtt cccagaacca tggtttctct tttcctttct tctccattcc ctgatgcatc
     2401 aatacttcca actgagaaaa agtccctcgg atcagaacca gtaccagccc cttgacattg
     2461 gcattggtgc cagataaggc ctgaggttag attcaaactg aattcctgca gatacccacc
     2521 gagtgcagtc aggactgtca aggccttcaa acaccagtga atgtgcactt agtgtgtcca
     2581 ctgtacaaga gacagcccgg aggatgacag atttgagggc acagagagag gactcctggg
     2641 agtcgtgcaa ggcacacata cactgccacc ttgaagtgca ggagagcaag acgctctgga
     2701 agggtgaaga gctttttgat ggagcaggca aggtgaagtt cagcctgcct tgagggcttc
     2761 ctctgggcac agccagctgc tttcgttttg gagcaacctc tcctggaggc cttgattgtg
     2821 aggcatgggt tgggatccag cagcagcagg gtgtcatctg gagcagaagg gaagtgggag
     2881 ggaaggctga gccaacgtta ttctttctga ggatcaaata tgcagcgtaa gcatattggt
     2941 aaccgaggag gctacacaga gaacatcaac tgaggggttt gtgtttctcc gaattctttg
     3001 aagtctggtg ccttctaagg aaggctgctg ttttggctcc tcgtagggcc caggacctgc
     3061 tgccgtaagt caaaagctcc agaactgcca ggacagtgtc tccaaggaat gagttcctcc
     3121 cataagggtc attcatggag cttggtggct agggtagatg agctgcaatc tgtcttgggt
     3181 ttttcttccc aaactcctcc cctcttctct ccatcatgcg ctctctggag agactgtccc
     3241 tcccaccctt ctccttcctg cccctcatgc ctgtgagttt tgtgtggcaa atctgttttt
     3301 ctctcaatgc agaaacgggg gaaaaagctg aactgtatgg agcctgtcct agctgtcagt
     3361 gcctgcatgc ttcgggggaa gcaggtgaaa tgaggccaat gaattcttac agcatttgcg
     3421 tttgggggga ggcacctgac tagtggtacc ttccttcctt ttggatttct ctccatccat
     3481 ttcttctctg cctccattct gtctctctcc cactcacagg ccgctgacag tcccacagct
     3541 ttcagcactc aatctttgcc tggccgtgca gagctgggtt ttgagcagga ttctgactag
     3601 gaggagggaa aaacgtggga tgcagagatt tcctgagggg aacatctgtg tctgtgcctg
     3661 aagagtggct gacctttcca gtgtcctttc tattctgatt tcatcaggga gaacgtctca
     3721 ataaagttcc aatctctctt caa
//
LOCUS       NM_001437357            1795 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 5, mRNA.
ACCESSION   NM_001437357 XM_063271318
VERSION     NM_001437357.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271318.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3322296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-207              JAXUCZ010000012.1  40093729-40093898
            208-397             JAXUCZ010000012.1  40096705-40096894
            398-517             JAXUCZ010000012.1  40098953-40099072
            518-699             JAXUCZ010000012.1  40100973-40101154
            700-881             JAXUCZ010000012.1  40102786-40102967
            882-1102            JAXUCZ010000012.1  40106323-40106543
            1103-1177           JAXUCZ010000012.1  40109132-40109206
            1178-1370           JAXUCZ010000012.1  40110908-40111100
            1371-1574           JAXUCZ010000012.1  40112332-40112535
            1575-1795           JAXUCZ010000012.1  40113600-40113820
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1795
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1717
                     /gene="Ccdc63"
                     /note="isoform 1 is encoded by transcript variant 5;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_001424286.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            38..207
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            208..397
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            398..517
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            518..699
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            700..881
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1102
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1177
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1370
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1574
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1795
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtgatg aagaaacaca ggaggaaggt
       61 ctctgaaccc cttccggaac tttccgagaa ggccaaagag cagttggctg aggcagagct
      121 acggaaacta aggcagcagt tccggaagat ggtagacagc cgaaagtctt ccaatttccg
      181 caaccagcgg atgatcgcca gccagtacaa ggagatagag aatttgaaag cggagcaggc
      241 agagaccacc ttgcttctga gcctcgtgaa gtcgccaaag aacctagacc tcaaccagaa
      301 aaatttcacg gagctgcgct tcctgctgca gaccaagggg gactacgagg ctctgatctc
      361 ctccatgaag gtgctgctgg gagaactgga tgacaagatt gttcagatgg agagaaagat
      421 cacaaaccag agacagatct tcttgaagac acaagaggcc aacaatcccc ggaagctgca
      481 gaaacagatc cacattctgg agaccagact gaacctggtc actgtccact ttgacacgat
      541 gttgacctcc aatgcccagc tccggaagga tattgaggat cttctctttg agaaggctgc
      601 ctacgaccat gtctaccagc agcttcagcg gcgtctgcag acacagaaga agaccatgaa
      661 tgtggccatc gagcagtcta cccaggccta tgagcagaga gtggaagcca tggctcggat
      721 ggctgccatg aaggaccgcc agcaaaaaga catctctcag tacaacctgg agatccgaga
      781 gctcgaacgc ctgtatgacc acgagaacaa actcaagtcc tttctgcttg tcaagctcaa
      841 tgaccgcacg gaattcgagg accaggccaa gaagcaggaa gctgtcaaaa ttaagaagca
      901 tgggaaaaag aggaagggtg agagctttga gagctacgag gtggcccatc tccgactgct
      961 aaagctggct gagaacgggg acctgaacca gctcactgag gacttcctgg ccaaggagga
     1021 gaagaatttt gctcgcttca cctatgtcac cgagctcaac aatgacatgg agaccatgca
     1081 caagaggacc cagcggatcc aggatgacat catcaacctg cggtcacagc agcagtcctc
     1141 ccatgagggc acccggaaca tcctgaaaca gatggaggag aaactgagga agaccaccga
     1201 ggacacggac atttatgaga acaggtacag ggaaatgagc aagaccctgg agtacctcaa
     1261 gaactcagtg gagaagctgt ttaagaagat caactgcaat gccacggaga tcctggggaa
     1321 actgggtgag actgggaaga tcacggacag caaccttcag cagtacttcg ctatcataga
     1381 aaagaagaca aatgacctcc tgcttctgga gtctttccgg cgcctgcagg aggcagaggg
     1441 gcccgatgtt gatgtcccac aaccctttgt caaccccttc tgggggggct ctgccctcct
     1501 caagccccca gagcccttaa gggttgtgcc gcctgtgttt ggggcagact ccttcagtga
     1561 caaagttgaa gaggttcctc acagagctct gtcctgggtg cagtggaata ccctctggac
     1621 cacagtagcc tccggcagct ggtcttggag aactaccttc agaaggaacg aggaaaagaa
     1681 ccacaggaga cactgttgga gaagggggac gagataaggg tcaagaagaa ggtgataagc
     1741 tgaaccccgt gggtggctgt attccacacc gagaaaataa atgttttctt gccga
//
LOCUS       NM_001437355            1896 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 3, mRNA.
ACCESSION   NM_001437355 XM_063271316
VERSION     NM_001437355.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.85247.1,
                                           SRR26360181.634133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-138              JAXUCZ010000012.1  40093232-40093332
            139-308             JAXUCZ010000012.1  40093729-40093898
            309-498             JAXUCZ010000012.1  40096705-40096894
            499-618             JAXUCZ010000012.1  40098953-40099072
            619-800             JAXUCZ010000012.1  40100973-40101154
            801-982             JAXUCZ010000012.1  40102786-40102967
            983-1203            JAXUCZ010000012.1  40106323-40106543
            1204-1278           JAXUCZ010000012.1  40109132-40109206
            1279-1471           JAXUCZ010000012.1  40110908-40111100
            1472-1675           JAXUCZ010000012.1  40112332-40112535
            1676-1896           JAXUCZ010000012.1  40113600-40113820
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1896
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            38..138
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             139..1818
                     /gene="Ccdc63"
                     /note="isoform 1 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     1"
                     /protein_id="NP_001424284.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVPHRALSWVQWNTLWTTVASGSWSWRTTFRRNEEKNHRRHCWRRGTR"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            139..308
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            309..498
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            499..618
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            619..800
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            801..982
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1203
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1278
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1471
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1675
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1896
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggac attgcagaca gaggagacac
       61 tgagagaacg agaaagaagt gggcttgcta gctttgacct ccaggaccca gtgtctaagc
      121 agaaaggaag cttagacgat gaagaaacac aggaggaagg tctctgaacc ccttccggaa
      181 ctttccgaga aggccaaaga gcagttggct gaggcagagc tacggaaact aaggcagcag
      241 ttccggaaga tggtagacag ccgaaagtct tccaatttcc gcaaccagcg gatgatcgcc
      301 agccagtaca aggagataga gaatttgaaa gcggagcagg cagagaccac cttgcttctg
      361 agcctcgtga agtcgccaaa gaacctagac ctcaaccaga aaaatttcac ggagctgcgc
      421 ttcctgctgc agaccaaggg ggactacgag gctctgatct cctccatgaa ggtgctgctg
      481 ggagaactgg atgacaagat tgttcagatg gagagaaaga tcacaaacca gagacagatc
      541 ttcttgaaga cacaagaggc caacaatccc cggaagctgc agaaacagat ccacattctg
      601 gagaccagac tgaacctggt cactgtccac tttgacacga tgttgacctc caatgcccag
      661 ctccggaagg atattgagga tcttctcttt gagaaggctg cctacgacca tgtctaccag
      721 cagcttcagc ggcgtctgca gacacagaag aagaccatga atgtggccat cgagcagtct
      781 acccaggcct atgagcagag agtggaagcc atggctcgga tggctgccat gaaggaccgc
      841 cagcaaaaag acatctctca gtacaacctg gagatccgag agctcgaacg cctgtatgac
      901 cacgagaaca aactcaagtc ctttctgctt gtcaagctca atgaccgcac ggaattcgag
      961 gaccaggcca agaagcagga agctgtcaaa attaagaagc atgggaaaaa gaggaagggt
     1021 gagagctttg agagctacga ggtggcccat ctccgactgc taaagctggc tgagaacggg
     1081 gacctgaacc agctcactga ggacttcctg gccaaggagg agaagaattt tgctcgcttc
     1141 acctatgtca ccgagctcaa caatgacatg gagaccatgc acaagaggac ccagcggatc
     1201 caggatgaca tcatcaacct gcggtcacag cagcagtcct cccatgaggg cacccggaac
     1261 atcctgaaac agatggagga gaaactgagg aagaccaccg aggacacgga catttatgag
     1321 aacaggtaca gggaaatgag caagaccctg gagtacctca agaactcagt ggagaagctg
     1381 tttaagaaga tcaactgcaa tgccacggag atcctgggga aactgggtga gactgggaag
     1441 atcacggaca gcaaccttca gcagtacttc gctatcatag aaaagaagac aaatgacctc
     1501 ctgcttctgg agtctttccg gcgcctgcag gaggcagagg ggcccgatgt tgatgtccca
     1561 caaccctttg tcaacccctt ctgggggggc tctgccctcc tcaagccccc agagccctta
     1621 agggttgtgc cgcctgtgtt tggggcagac tccttcagtg acaaagttga agaggttcct
     1681 cacagagctc tgtcctgggt gcagtggaat accctctgga ccacagtagc ctccggcagc
     1741 tggtcttgga gaactacctt cagaaggaac gaggaaaaga accacaggag acactgttgg
     1801 agaaggggga cgagataagg gtcaagaaga aggtgataag ctgaaccccg tgggtggctg
     1861 tattccacac cgagaaaata aatgttttct tgccga
//
LOCUS       NM_001437364            1785 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 13, mRNA.
ACCESSION   NM_001437364 XM_063271324
VERSION     NM_001437364.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271324.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2324488.1,
                                           SRR26360181.1377122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-207              JAXUCZ010000012.1  40093729-40093898
            208-397             JAXUCZ010000012.1  40096705-40096894
            398-517             JAXUCZ010000012.1  40098953-40099072
            518-699             JAXUCZ010000012.1  40100973-40101154
            700-881             JAXUCZ010000012.1  40102786-40102967
            882-1102            JAXUCZ010000012.1  40106323-40106543
            1103-1177           JAXUCZ010000012.1  40109132-40109206
            1178-1370           JAXUCZ010000012.1  40110908-40111100
            1371-1574           JAXUCZ010000012.1  40112332-40112535
            1575-1785           JAXUCZ010000012.1  40113610-40113820
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1785
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1618
                     /gene="Ccdc63"
                     /note="isoform 3 is encoded by transcript variant 13;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     3"
                     /protein_id="NP_001424293.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEELCPGCSGIPSGPQ"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <473..1294
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            38..207
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            208..397
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            398..517
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            518..699
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            700..881
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1102
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1177
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1370
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1574
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1785
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtgatg aagaaacaca ggaggaaggt
       61 ctctgaaccc cttccggaac tttccgagaa ggccaaagag cagttggctg aggcagagct
      121 acggaaacta aggcagcagt tccggaagat ggtagacagc cgaaagtctt ccaatttccg
      181 caaccagcgg atgatcgcca gccagtacaa ggagatagag aatttgaaag cggagcaggc
      241 agagaccacc ttgcttctga gcctcgtgaa gtcgccaaag aacctagacc tcaaccagaa
      301 aaatttcacg gagctgcgct tcctgctgca gaccaagggg gactacgagg ctctgatctc
      361 ctccatgaag gtgctgctgg gagaactgga tgacaagatt gttcagatgg agagaaagat
      421 cacaaaccag agacagatct tcttgaagac acaagaggcc aacaatcccc ggaagctgca
      481 gaaacagatc cacattctgg agaccagact gaacctggtc actgtccact ttgacacgat
      541 gttgacctcc aatgcccagc tccggaagga tattgaggat cttctctttg agaaggctgc
      601 ctacgaccat gtctaccagc agcttcagcg gcgtctgcag acacagaaga agaccatgaa
      661 tgtggccatc gagcagtcta cccaggccta tgagcagaga gtggaagcca tggctcggat
      721 ggctgccatg aaggaccgcc agcaaaaaga catctctcag tacaacctgg agatccgaga
      781 gctcgaacgc ctgtatgacc acgagaacaa actcaagtcc tttctgcttg tcaagctcaa
      841 tgaccgcacg gaattcgagg accaggccaa gaagcaggaa gctgtcaaaa ttaagaagca
      901 tgggaaaaag aggaagggtg agagctttga gagctacgag gtggcccatc tccgactgct
      961 aaagctggct gagaacgggg acctgaacca gctcactgag gacttcctgg ccaaggagga
     1021 gaagaatttt gctcgcttca cctatgtcac cgagctcaac aatgacatgg agaccatgca
     1081 caagaggacc cagcggatcc aggatgacat catcaacctg cggtcacagc agcagtcctc
     1141 ccatgagggc acccggaaca tcctgaaaca gatggaggag aaactgagga agaccaccga
     1201 ggacacggac atttatgaga acaggtacag ggaaatgagc aagaccctgg agtacctcaa
     1261 gaactcagtg gagaagctgt ttaagaagat caactgcaat gccacggaga tcctggggaa
     1321 actgggtgag actgggaaga tcacggacag caaccttcag cagtacttcg ctatcataga
     1381 aaagaagaca aatgacctcc tgcttctgga gtctttccgg cgcctgcagg aggcagaggg
     1441 gcccgatgtt gatgtcccac aaccctttgt caaccccttc tgggggggct ctgccctcct
     1501 caagccccca gagcccttaa gggttgtgcc gcctgtgttt ggggcagact ccttcagtga
     1561 caaagttgaa gaggagctct gtcctgggtg cagtggaata ccctctggac cacagtagcc
     1621 tccggcagct ggtcttggag aactaccttc agaaggaacg aggaaaagaa ccacaggaga
     1681 cactgttgga gaagggggac gagataaggg tcaagaagaa ggtgataagc tgaaccccgt
     1741 gggtggctgt attccacacc gagaaaataa atgttttctt gccga
//
LOCUS       NM_001437240            4189 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus myogenesis regulating glycosidase (Myorg),
            transcript variant 3, mRNA.
ACCESSION   NM_001437240 XM_006238094
VERSION     NM_001437240.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4189)
  AUTHORS   Datta,K., Guan,T. and Gerace,L.
  TITLE     NET37, a nuclear envelope transmembrane protein with glycosidase
            homology, is involved in myoblast differentiation
  JOURNAL   J Biol Chem 284 (43), 29666-29676 (2009)
   PUBMED   19706595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006238094.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228576.1, SRR26643296.14973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000005.1  61460228-61460304   c
            78-4189             JAXUCZ010000005.1  61452956-61457067   c
FEATURES             Location/Qualifiers
     source          1..4189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4189
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="myogenesis regulating glycosidase"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
     exon            1..77
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     exon            78..4189
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    131..133
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="upstream in-frame stop codon"
     CDS             140..2290
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /codon_start=1
                     /product="myogenesis-regulating glycosidase"
                     /protein_id="NP_001424169.1"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
                     /translation="MPQNLQEKSQVYPRHRLGSHAGPKSLEVIPGATMYTFLPDNFSP
                     AKPKPTKELRPLLCSVVLGLLLVLAAVVAWCYYSASLRKAERLRAELLDLNRGGFSIR
                     NQKGEQVFRLAFRSGALDLDSCSRDGALLGCSRTADGRPLHFFIQTVRPKDTVMCYRV
                     RWEEAAPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDA
                     AFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSMRLQARYHHTSYKPPAGRTAAP
                     ELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPASEAFRDPIWSTWALYGRSVDQNKVLQ
                     FAQQIRQHRFNSSHLEIDDMYTPAYGDFDFDESKFPNATDLFHRLRDAGFRVTLWVHP
                     FVNYNSSRFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTRPEAREWFQGHLRRL
                     RSRYNVASFKFDAGEVSYLPPDFSTYKPLSDPSVWSRRYTEMALPFFSLAEVRVGYQS
                     QNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMIGGNAVPERTAGRP
                     DGPGPERELYVRWLEVAAFMPAMQFSIPPWQYDAEVVAIAHKFAALRASLVAPLLLEL
                     AGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAG
                     KWRSYKGELFDKTPVLLTDYPVDLDEVAYFTWAS"
     misc_feature    1076..2191
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    1076..2191
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    order(1193..1198,1517..1519,1523..1528,1640..1642,
                     1694..1696,1946..1948,1952..1954)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
     misc_feature    order(1193..1198,1517..1519,1523..1528,1640..1642,
                     1694..1696,1946..1948,1952..1954)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
ORIGIN      
        1 ggctgatcaa ctcctgctag cgtggagaga ggatcagctg gaggaccctt cttcccttct
       61 ttgtggcggt cactgagaca tcagcacgac agtttcagat gggccctggt gtggtggttc
      121 ctttcttagc taggaactga tgccccagaa ccttcaggag aagagccagg tctaccccag
      181 acatcgactt ggtagccacg caggccctaa aagtctcgaa gttatcccag gagcaaccat
      241 gtacactttc ctgcctgaca atttttcacc tgccaaaccc aagcccacta aagagctgag
      301 gcctctgcta tgctccgtgg tactgggact gctgctggtg ctggccgcag ttgtggcctg
      361 gtgctactat agcgcctcct tacgcaaagc tgaacgcctg cgcgcagagc tgctggacct
      421 gaaccgtggc ggcttctcca tccgtaacca gaagggtgag caagtcttcc gcttggcctt
      481 ccgttcgggt gcgctggatc ttgactcctg tagccgggac ggtgccctgc ttggctgctc
      541 ccgaacggcc gatgggcgcc cgttgcactt ctttatccag actgtacgac ccaaggacac
      601 tgtaatgtgc taccgcgtgc gctgggagga agctgcacca gggcgtgctg tagagcacgc
      661 gatgtttctg ggagatgctg cagcgcactg gtatggtggc gcagagatga ggacgcaaca
      721 ctggcccatc cgcctagatg gccagcaaga gccgcagcca tttgtcacga gcgacgtcta
      781 ctcttctgac gccgcattcg ggggcatcct tgagcgctac tggctatctt cccgcgcggc
      841 cgccatcaaa gtcaatgatt cagtgccctt ccacctgggc tggaacagca ccgagcgttc
      901 gatgagattg caggcacgct accaccacac atcttacaag ccaccagccg gccggactgc
      961 agcgccagag ctcagctacc gcgtgtgcgt gggctcagat gtcacctcca tccacaagta
     1021 catggttcga cgttacttca acaaaccgtc cagggtacca gcgtcagagg ccttccgaga
     1081 ccccatttgg tccacgtggg ctctatatgg gcgctctgtg gaccagaaca aggtgctgca
     1141 attcgcccag cagatccgcc agcaccgctt caacagcagc catctggaaa tcgatgacat
     1201 gtacacgccg gcctatggtg actttgattt cgacgagagc aagttcccca acgccactga
     1261 cctgttccac cgcctgcgag atgctggctt ccgcgtcaca ctttgggtgc atccgtttgt
     1321 caactataac tcgtcgcgtt tcggcgaagg tgtggagcgc gagctgttcg tgcgggagcc
     1381 cacgggccgc ctgcccgcgc tcgtgcgctg gtggaacggc attggcgcgg tgctggactt
     1441 cacgcgccca gaggcccgag agtggttcca gggacaccta cggcgcctgc gctcgcgcta
     1501 caacgtggcc tcctttaagt tcgacgcggg tgaagtcagc tacctgcccc cggacttcag
     1561 cacctacaag cctctgtctg accccagtgt gtggagcagg cggtacaccg agatggcgct
     1621 gcccttcttc tcgctagccg aagtccgcgt ggggtaccag tcacagaaca tctcctgctt
     1681 cttccgtcta gtggaccgcg actcggtatg gggctacgac ctggggctgc gctctctcat
     1741 ccctgcggtg ctcaccgtca gtatgctggg ctatccgttc atcttacctg atatgatagg
     1801 tggcaacgcg gtgccggagc gcacagcggg ccgcccagat gggccggggc cagagcgcga
     1861 actctacgtg cgctggctgg aggtggccgc cttcatgcct gccatgcagt tttcaatccc
     1921 tccttggcag tatgacgcag aagtggtagc catcgcacat aaattcgctg ctctgcgcgc
     1981 ctccctcgtg gcgccactgc tgctggagct tgctggtgag gtcaccgaca cgggcgaccc
     2041 catcgtgcgc cccctgtggt ggatcgcacc cggggatgaa acggctcacc gcattgactc
     2101 acagttcctc atcggggaca cgctgttggt ggcaccggta ctggaacctg gtaagcaaga
     2161 gcgcgatgtc tacctgcctg ccggcaaatg gcgaagttac aagggtgagc tttttgacaa
     2221 gacgcctgtg ctgctcacgg attaccctgt cgacctggat gaggtcgcct atttcacctg
     2281 ggcttcctga cccagctcag aacctaggaa tcccacagcc ctaaccccag ccttcataca
     2341 aacttttaat cctctaccac gcgcgaacgg tgaaccctca ggaagacccc acctctatac
     2401 catctaggaa gtgggcaccg actttaaagt gctccagcca acagctgtag atgagacctg
     2461 ggaggggagg tattgaaaca acccctgcac cagcgcacaa tcctaagagt cccggttcct
     2521 tgaccattcg ctccagtctg cagaaagcct ctcccttggg ttggagggca gagaactgag
     2581 aggacaaaga tctgttcttt gtgttacaca gggtctggtt ttaaaagcac agaaagaaac
     2641 ctctcctccc accctggtct ttgtagccat ccttgtcctc tgaaatgagg aaccaatcct
     2701 ctttaaaagt tcccaaatag ttttctgcca tatttagaaa gtgtaccttt aacctggtgt
     2761 tggtgggata tgcctttaat accagcactc aggaagcaga gagacaggtg gatctccgag
     2821 atcaaggcca gcatggtcta cagatcgagt tccaggaagc cagcgctacg cagagaaact
     2881 ctatctccaa aaaactgaag gaaggaagga aagaagaaag gaaggaagga agaaaggaag
     2941 gaagaagaga aagtctacct tcttgatgac agcagctaag ccatgagctc ccagcacaca
     3001 cctgaacagt gactgacctg ctctcactcg atctggggaa gaaagataca cagatgtttg
     3061 gtttggccag ctgaccagga agcaaaaggc ctcttcccag tccataggag aattgaactg
     3121 aactaatgtt ctctgtctgt gagaaagact cctaacatgc gttaacatat ttgtatgtat
     3181 tcatacccag acctgggcca gatgtgccta gtagatagac ttgcagggtc atgcaggccg
     3241 gactcgttgc cttaattcaa gaacctgtgt ctatgtgtat gtacacatac ttctgtcagg
     3301 gcagtgggga gggagagagg gagagaggcg cccaccatgg gtctctgaaa tattcctgag
     3361 gctagataag cctagaggga ggatacggag gcagcctcag ggctttgatt atgatctaag
     3421 ccccatttta ggtagactcc ctaggatact gccaaaccca gtttaagagt ttaaaactgg
     3481 agaactgggc tgaggaactg actcagaaga caagcctgac tacctgagtt cagcctaact
     3541 cctgctgtaa aaggagagaa cggacaatag ggtaagccct ttaagattac ccagctgcct
     3601 ccctgcacac acgctctgag tgtagcccga acgggaaaac catgttctat gctggcagag
     3661 atgtgcttgg cacacgaatg acattacacg ctgataacct gccagcacac gtatggggaa
     3721 gggctttcat ctcagtaatt ctcttgttct aagaagatca actccagcta ccgtgaggtg
     3781 agtttttcct gatttgccag agaaggtggg gaatgaagtg gggctcagct tccctctcag
     3841 agcctgtgcc cgaatcattc gttttctctg ggtgaaaggt cctggtgaga gcttcagggc
     3901 tccccagacg cccatctcca tgccaattct tttgtttctt ttccttggca atgctgaagc
     3961 tagaacccag ggccccaagc atactaagta agcattcttc ctcagctcta tcctcggtct
     4021 tcagccagcc gggtgacctt gaataagctg ctgcctaccc cactgagcct cagtgttttc
     4081 tgtgtaaggg tgatgtaatg cctacctcta aggtcacttt aataataagc acagacatat
     4141 ggaaagtgcc tgacaccaag taggtgctca ataaaagata gctattgta
//
LOCUS       NM_001437302            1201 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 9, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437302
VERSION     NM_001437302.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3266738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               JAXUCZ010000011.1  44781963-44782490
            529-668             JAXUCZ010000011.1  44823304-44823443
            669-1201            JAXUCZ010000011.1  44825271-44825803
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1201
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..528
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    523..525
                     /gene="Mrps6"
                     /note="upstream in-frame stop codon"
     exon            529..668
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..795
                     /gene="Mrps6"
                     /note="isoform 5 is encoded by transcript variant 9; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 5"
                     /protein_id="NP_001424231.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MDRGAIVRNLENLGERALPYRISSHSQQHSRGGDSARTSLFVGE
                     GLMESHIAEGATGGGVLSTLSKKGEHLPEA"
     misc_feature    <571..>666
                     /gene="Mrps6"
                     /note="Bacterial ribosomal protein S6; Region: bS6;
                     cl00414"
                     /db_xref="CDD:469763"
     misc_feature    <571..>666
                     /gene="Mrps6"
                     /note="Bacterial ribosomal protein S6; Region: bS6;
                     cl00414"
                     /db_xref="CDD:469763"
     exon            669..1201
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcctcg gaccccggct ctccggagtc cgatggaagg actgcgggag gacacacgcg
       61 cgagaaccca ggccggcccc gctctgcgcc cacgggtcga gaagctgctc gtcgtcccga
      121 tcgcctgccc tcagcgtccg cgatcagtac agccttccac caaagcccgc cagtgccggc
      181 tgtgtacccc acgcacttgt caccgctgtc acgctaaaaa aaaaaatctt ttgacctttc
      241 tttttctgac tccagcgaaa atcctgctcc gggtaccctt agcccagttt tattcatcca
      301 agttgtggcc ttgcttgtgc tttccgaaga cgtgtcttcc cccagctttt gattgatctt
      361 gaggtaggga ctttcaggtt tggagggatg ataaaccacc agcagccggg tcacggactg
      421 gggtcagcgg tggaggcagc tatcttcgtc ctctgttctg agtcaggcac ttctcaatcg
      481 tcgctgaaat ccccattctt ctgagagaat tcggtaacgt agtagcagcc agagaccgct
      541 gctgctttaa aacgtacaat agaatccctg atggaccgag gagccatagt gaggaacttg
      601 gaaaacctgg gtgagcgtgc actcccatac aggatctcca gtcacagcca gcagcacagc
      661 cgaggaggag actcagcccg aacctcactg tttgttggag agggtttaat ggagtcacac
      721 attgcagagg gagcaacggg aggaggtgtt ttgtcgactc tttctaaaaa gggcgagcat
      781 ctccctgagg cctagtgata ctccactgca cagcagccag cctcactcca ggactgcaca
      841 ccgtttgaag ctctttgcac taggtgctgg agggaggaca gcaaaagaac tggtgatctc
      901 tcagtgctga acttgtgtgt ccggtggcct gtgactggcc aggagactgg gctcacttcc
      961 atgcttgtaa gaactcttca gttgggggct ggagagatgg ctcagaggtt aagagcactg
     1021 tctgctcttc cagaggtcct gagttcaatt cccagcaacc acatggtggc tcacaaccat
     1081 ctatagtcag gtctggtgcc ctcttctggc ctgcagacat acatgcaggc agaaagctgt
     1141 atgatgtata cataataaat aaataaatgt taaaaaaaaa tctttaaaaa aaaaaaaaga
     1201 a
//
LOCUS       NM_001437426            2005 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus polo-like kinase 5 (Plk5), transcript variant 3,
            mRNA.
ACCESSION   NM_001437426 XM_006240923
VERSION     NM_001437426.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006240923.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38028.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000007.1  10005661-10005843   c
            184-291             JAXUCZ010000007.1  10004242-10004349   c
            292-421             JAXUCZ010000007.1  10003456-10003585   c
            422-509             JAXUCZ010000007.1  10002630-10002717   c
            510-605             JAXUCZ010000007.1  10002452-10002547   c
            606-804             JAXUCZ010000007.1  10001658-10001856   c
            805-931             JAXUCZ010000007.1  10001445-10001571   c
            932-1008            JAXUCZ010000007.1  10001180-10001256   c
            1009-1081           JAXUCZ010000007.1  10000771-10000843   c
            1082-1216           JAXUCZ010000007.1  10000436-10000570   c
            1217-1373           JAXUCZ010000007.1  9999984-10000140    c
            1374-1503           JAXUCZ010000007.1  9998944-9999073     c
            1504-1614           JAXUCZ010000007.1  9998755-9998865     c
            1615-2005           JAXUCZ010000007.1  9997453-9997843     c
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2005
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polo-like kinase 5"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
     exon            1..183
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1806
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /EC_number="2.7.11.21"
                     /note="isoform 3 is encoded by transcript variant 3;
                     polo-like kinase 5 pseudogene; serine/threonine-protein
                     kinase PLK5; inactive serine/threonine-protein kinase
                     PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5
                     isoform 3"
                     /protein_id="NP_001424355.1"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
                     /translation="MEPRLRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYL
                     HQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSR
                     NGHSAKSDIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIA
                     RLLAPDPDERPSLDHLLQDDFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQL
                     LLTQCRPPCPFTSKEASGPGEESTEPDHMEASNEEGAPLCTESRIHLLTLGTPRTDPA
                     DAKGTLALQLEVATRKLCLCLDAGPVGRTATPKCRTEAAWRGPKPAGQDPPGEQRSVL
                     WAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRD
                     VPGPLRAKLAVLRLFACYMQRRLREEGTAPMTATPASPDFCLLSFTADAQALAMLFSN
                     GTVQVSSKTSPVQLVLSGEGEDFLLTIQEPGGPSMGTSYTLDVLRSHGISLAVRHHLR
                     LGLHLLQSV"
     misc_feature    151..798
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    151..798
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    157..1449
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Serine/threonine protein kinase [Signal
                     transduction mechanisms]; Region: SPS1; COG0515"
                     /db_xref="CDD:440281"
     misc_feature    157..1449
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Serine/threonine protein kinase [Signal
                     transduction mechanisms]; Region: SPS1; COG0515"
                     /db_xref="CDD:440281"
     exon            184..291
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            292..421
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            422..509
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            510..605
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            606..804
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            805..931
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1008
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1081
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1216
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1373
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1503
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1614
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..2005
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcggcag cgctgcaggc agcactggct tgcccagttc ccgcgcgcgc gctgcgcacc
       61 caggcccacc ccgcgtcgat ggagccccgg ttgaggcggc ggcgaagccg ccagctagtg
      121 gccaccttcc tgcgtgaccc gggctcaggg cgcgtgtacc ggcgcgggaa gctgatcggc
      181 aagggcgcct tcagccgctg ctacaagctc acggacatgt ccaccagcgc ggtgtttgct
      241 cttaaggtgg tgccgagggg cggagcgggg cggctgcgcc tgcgcgggaa gtccttggct
      301 catgtactga aagtgcggcg gaccctgacg gagcctgaag tgcgctacta ctttcggggc
      361 ctggtcagtg gcctccgcta cctgcaccaa caacgcatcg tgcacaggga cctgaaaccc
      421 agtaatttct tccttaacaa gaacatggaa gttaagatag gtgacctggg gctggctgcc
      481 cgtgtggggc ccgctggccg ctgccacagg gtgctctgtg ggactccgaa cttccaggct
      541 cctgaagtgg tgtcccgaaa tggacactcg gccaagtctg acatctgggc cctggggtgc
      601 attatgtaca cggtgctgac gggcacgccc cccttcgctg ccgcaccctt gtccgagatg
      661 taccaaaaca tccgagacgg tcactacctt gagcccactc agctgtcacc cagcgcccgt
      721 agcctcattg cacgacttct ggcaccggac cctgatgagc ggcccagcct ggaccactta
      781 ctgcaagatg acttttttag tcagggcttt accccagagc ggctgcctcc acattcctgc
      841 cacagcccac ccgtgtttgc cttccccccg ccactgggca ggttgttccg gaaggtgggc
      901 caactcctgc tgacccagtg ccggccgccc tgtcccttta cctcaaaaga ggcctcaggc
      961 ccgggagaag agagtacaga acctgaccac atggaggcca gcaacgagga aggggctcct
     1021 ctctgcactg agagccgaat ccacctcctc actcttggaa cccctcggac tgacccggcc
     1081 gatgcgaagg ggaccttggc cctgcagctg gaggtggcaa ccagaaaact gtgcctctgc
     1141 ttggatgcag gacctgtggg taggacggcc accccaaagt gcaggactga ggcagcctgg
     1201 aggggcccta aaccagctgg acaggacccc cccggggagc agcgctctgt cctctgggct
     1261 cccaagtggg tggattattc cctcaagtat ggcttcggtt accagctgtc ggatgggggc
     1321 agtggcgtgc tgtttcggga tggctcccac atggccctgc gccccccagg aggccatgtc
     1381 tcctaccaac ctgaccaagg gactctgtgg atcttcgccc tgagggacgt ccccggccca
     1441 ctccgcgcca agctggccgt cctgaggctc tttgcctgct acatgcagcg gcgtctgcgg
     1501 gaggagggga cagcacccat gacggccaca cccgcctctc ctgacttctg tctgctgagc
     1561 ttcaccgctg atgcccaagc tctggccatg ctctttagca atgggacagt gcaggtcagt
     1621 tccaaaacct ccccagtcca gctggtgctg agtggggaag gcgaggactt tctgctcacc
     1681 atccaggagc cagggggacc cagcatgggc acctcctaca cgctggacgt cctgcggagt
     1741 cacggcatca gccttgcggt ccgccaccac ctgcgccttg gactgcatct gcttcagagt
     1801 gtctaaggag ccggacggag atctgggcgg acctctgcgt gatggtgctg gtgtctgttt
     1861 ctgtctgcgc tcctccgcca cagccagtgt ctgtggaggg tggacacatt gggacctctg
     1921 atgggtgggc gtctttgatt atttgactac tcaaggtaga ctttttttgg attttcatta
     1981 aagaaaacag aaccctttaa actgc
//
LOCUS       NM_001437381             933 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 5, mRNA.
ACCESSION   NM_001437381 XM_063275739
VERSION     NM_001437381.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063275739.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1595485.1,
                                           SRR26360176.1858894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000016.1  82528885-82529058   c
            175-255             JAXUCZ010000016.1  82512490-82512570   c
            256-425             JAXUCZ010000016.1  82508838-82509007   c
            426-933             JAXUCZ010000016.1  82504477-82504984   c
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..933
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..174
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             85..432
                     /gene="Cfap97d2"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 5"
                     /protein_id="NP_001424310.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKSKQEIERTGIDESAETKSSRSRKTQKLRALVWSTEMAGGLDCHGH
                     ASLHMQTHLEKRS"
     exon            175..255
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..425
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..933
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatgaccc cgcaaacagc tctgcggggg ctgtactgct gtgcctgctc ttccctgaag
       61 ggaccctgga gtttgtgatc tgagatgcat agagtgcccc agctgaccac cccgtgggct
      121 agtagagacc tgcagagagc ctgggagaaa acctaccaga accacaggaa aaaggtccag
      181 aacgcccaac cactcgtgga cacccgccca ccacagactt acagccacct ccacctaaag
      241 ttcaagaagt tgaagtctaa acaggaaatc gagagaacag gcattgatga aagtgcagaa
      301 acaaaatcaa gccgttccag aaagactcag aagctcagag ccctggtatg gagcacagag
      361 atggcgggag gactggactg ccatggccac gcgtccctgc acatgcagac acacctggag
      421 aaaaggagct gatcgtgaag cccaacaagg ccacagcctc atctggatgc gcagcctgaa
      481 gcggaagggg tgagggttca cgacccaacc accgaaagaa gaccagggcc tggaagctcc
      541 gatgaggcct tcctgtgtct cccaggggtg ggggtgggga tgtggggtgt gcaggtctag
      601 catccgagat cacgctggct ctggggacgg ctgtgggagc tgtgacgcgg cactctgaag
      661 cttcacggtc acggccgtcg ccagatgaca cagcacggct gtttactgtg tttcttggac
      721 cgataaccaa aaacaaaata tgcagagtga ctctgcgagt tacaggattt gaattagacg
      781 actctccttt ctagctgtta ctacttctct gagttaacat gagtttgggc gggtgtatgt
      841 aattctcttt aaaaacaaca acagaacaaa caaaaatacc tctgtgactg tcattttacc
      901 aagtatgtaa ataaatcaaa ctgagagctt taa
//
LOCUS       NM_001437469            2467 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus GRAM domain containing 2B (Gramd2b), transcript
            variant 3, mRNA.
ACCESSION   NM_001437469 XM_063277299
VERSION     NM_001437469.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277299.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.41451.1,
                                           SRR22399492.515284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000018.1  52112803-52113013
            212-323             JAXUCZ010000018.1  52153538-52153649
            324-390             JAXUCZ010000018.1  52155530-52155596
            391-494             JAXUCZ010000018.1  52157431-52157534
            495-590             JAXUCZ010000018.1  52160835-52160930
            591-662             JAXUCZ010000018.1  52163592-52163663
            663-743             JAXUCZ010000018.1  52163752-52163832
            744-855             JAXUCZ010000018.1  52167125-52167236
            856-978             JAXUCZ010000018.1  52167894-52168016
            979-1066            JAXUCZ010000018.1  52169053-52169140
            1067-1171           JAXUCZ010000018.1  52170384-52170488
            1172-1265           JAXUCZ010000018.1  52175620-52175713
            1266-2467           JAXUCZ010000018.1  52178855-52180056
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11-q12.1"
     gene            1..2467
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain containing 2B"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
     exon            1..211
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1307
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="isoform 3 is encoded by transcript variant 3; GRAM
                     domain-containing protein 3; GRAM domain-containing
                     protein 2B; GRAM domain containing 3"
                     /codon_start=1
                     /product="GRAM domain-containing protein 2B isoform 3"
                     /protein_id="NP_001424398.1"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
                     /translation="MTELQQEVEDAKPAKVLTKREGKVGPAQSKSSFDGSNLLSDKND
                     CKTESKADSKTERKKSSSSSQYKANMHFHKLFLDVPTEEPLRQSFTCALQKEILYQGK
                     LFVSENWICFHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSL
                     LSRDSTYKLLKSICGHLENTSVGNSPNPSSAENSFRADRPSSLRLDFNDEFSDLDGVV
                     QQRRQDLEGYSSSGSQTPESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGK
                     AKILPAHGQSETIGILHKMESRKCPTLRHILIFYAIIVCALIISTFYMRYRINTLEER
                     LGSLTSIMDPHSTEQTAPSSLGSQVQLNVEVLCQELTANIVTLEKIQNNLQKLLENGD
                     "
     misc_feature    372..650
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     misc_feature    372..650
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     exon            212..323
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            324..390
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            391..494
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            495..590
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            591..662
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            663..743
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            744..855
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            856..978
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1066
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1171
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1265
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2467
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgtgtcca tgttggcggc ccgggagctc agctgcctgg atgcgcagcg ttagggtgca
       61 ggagaacagg gagccgggag ccccgaatag ggagccgagt cctggggtac tcccgggacg
      121 cggccctgat gactgagctc cagcaagagg tggaggacgc caagccagcc aaagtgctca
      181 ccaagagaga aggcaaagtt ggcccggccc agtcaaaatc cagttttgat ggctccaatt
      241 tgttgagcga taagaatgac tgtaaaaccg aaagcaaggc tgactctaag accgaaagaa
      301 aaaagtcttc ctcctccagc cagtacaagg caaacatgca ctttcacaag ctattccttg
      361 atgtcccaac cgaggagccc ctgagacaaa gctttacctg tgctctccag aaagaaattc
      421 tgtaccaagg aaagctcttt gtgtcggaaa actggatttg ttttcattcc aaggtctttg
      481 gaaaagacac taagatctct atcccagcct tttcggtaac cttgatcaag aaaaccaaaa
      541 ctgcccttct ggtgccaaat gccctgatca tagcgacggt cacagacagg tacatattcg
      601 tttccttgct gtccagagac tcaacctaca aactgctaaa atctatttgc ggacacttag
      661 agaacacaag tgtcgggaac agtcccaacc catcttctgc tgaaaatagc ttccgggcag
      721 atcgcccttc ctctctgcgt ctggatttca atgatgaatt ctcagacctg gacggagtgg
      781 ttcaacaacg aaggcaagac ttggaaggat acagcagttc cggctcccag actccagaat
      841 ctgagaactc tcgagacttc catgtgaccg aatctcagac agttctgaat gtcacaaagg
      901 gagaaacaaa accacctcgg acagatgccc acgggagcag agcgcctgat ggaaaagcca
      961 agatcctgcc tgcccatggt caatcggaaa ctattgggat tttacataaa atggagtctc
     1021 ggaagtgtcc aactctccgt catatcctta tattctacgc cattattgtc tgtgcgttga
     1081 tcatctccac cttctacatg agatacagga ttaacactct ggaggagcgc ctggggtcct
     1141 tgacgtccat catggatccc cacagtactg agcagacagc cccctccagc ctaggatcac
     1201 aagtacagtt aaatgtggag gtcctctgcc aagaacttac agctaacata gtgacattag
     1261 aaaagataca aaacaactta cagaagctgc ttgagaatgg ggactgagtg accagctgct
     1321 ggggccaaca taatacctca cgttctccct tgaagaaggt gcttctcgag agtctgttgt
     1381 gcgccccctg ctggccagag gcgcaagatg ctgagaatcc agatgtgttt gcgcttggag
     1441 gtctccagct caggaagggg ggaggggaat gagtttgctt tcgtgcaata aaagttgacc
     1501 ttgtctctgc tgctgcctga agataacaga cccatctcgg gaggtgagca aggtcctgga
     1561 ggacacctgt aacactcggg ttatggtaac atcagtaaac acagcactcc acgcttgtca
     1621 gctctttctc agccattgct gccttcaccc acaccaatca gccttcagac ctaaggggag
     1681 gtacactgta taccaccaaa ctcaaaatgg tcctttagag aattagtcac gagcctccaa
     1741 caaggtggtg aatctctctc aatgagcagg cttgcttctg acaccttcac gtttgtggtt
     1801 ttgtttttgt tttcgtgttc ccttctactc ttatgttctg gtttctttca tctgtgcctt
     1861 taaattttcc aattcggttg ggtgagcatg tccggtaaag tgaattaaat gtcccatctg
     1921 tgttgtgctg tcttgcgcct gtgactagta cgtaattgga gtgattctcc ccaacctccc
     1981 gtcaggaatc tttgaggtgt gacattgaaa tactaaatca gattcgctct gaaaccaaaa
     2041 ctaatctttc agcccaaagc tgtcctagaa atgtaatatg ggaaggaaag ccccgttcct
     2101 ggggttgtaa gtgcagtggg agctttgaag caggatgtct gtgttggact ctaaaaccca
     2161 tttcagcatg gtaattggat gtctttctcc tacaataaag cgtaagtggt ggtctgctaa
     2221 ctttacttac agtatgggtt ggctggtttt tattaataat gatttagggt accataagat
     2281 ctgtaagtat aaaacattct atctgcgatg cattttataa tcatttctat gaaatgtatt
     2341 ttgtttaatc agagaagcta ataagcggat tggccgtgtc atgtgtattg gtctgcgtat
     2401 tgggtaactg tgcctggtgc acccccggct tttaataaat actcattgcc taaggcaccc
     2461 tagttaa
//
LOCUS       NM_001437453            1723 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 11, mRNA.
ACCESSION   NM_001437453 XM_063284139
VERSION     NM_001437453.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284139.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2424813.1,
                                           SRR26360181.934275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-626             JAXUCZ010000001.1  104572249-104572332
            627-913             JAXUCZ010000001.1  104572931-104573217
            914-1108            JAXUCZ010000001.1  104574234-104574428
            1109-1282           JAXUCZ010000001.1  104574810-104574983
            1283-1418           JAXUCZ010000001.1  104576616-104576751
            1419-1543           JAXUCZ010000001.1  104577708-104577832
            1544-1723           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1723
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1700
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     11"
                     /protein_id="NP_001424382.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKL
                     EAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQK
                     VSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSA
                     RGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHV
                     LNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHK
                     KILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPEEKVATLDYMHLKM
                     CSLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ"
     misc_feature    135..1697
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..1697
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..626
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..913
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1108
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1282
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1543
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1723
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 aggagaactg ccgcaaggtg acccgttcag tggaagacgc tgaaatcaaa accaatgtcc
      601 tgaagcagaa ctctgccttg ttggaggaga agctaagata cctccagcag caactgcagg
      661 atgagacgcc ccggagacag gaggccgagt tgcaggagct ggagcaaaaa ctagaggctg
      721 gcctctcccg gcatggccta ggccctacta ctcccattca gggctgctcc ggtcctcctg
      781 gtagcccgga ggaacccccg cggccgcgag gcctgccctc caatggctgg ggcatggcaa
      841 tccgcgcagg ggagggaccc tcgctgagcg agcaggagtt gcagaaggtc tccagcggcc
      901 tagaggagct gaggagggag gtgtcctcgc tggcagctcg gtggcatcag gaggaggggg
      961 cggtgcagga ggccctaagg ttgctgggag gcctgggcgg ccgtctggat ggctttctgg
     1021 gccaatggga gcgggcgcag cgggaacaag cacagtccgc acggggtttg caggagctgc
     1081 gaggacgagc agatgagctg tgcactatgg tggagaggtc agcagtgtct gtcgcttcac
     1141 tgaggagcga actggaggca ctgggcccag taaaaccgat tctggaggag ctgggacggc
     1201 aacttcaaaa ctcccgaagg ggacctgacc atgtcttgaa cttggatcgt cctgcccaag
     1261 gtccctgtcc tcgatgtgcc agccaggggc agcagttatc cacggagtcc ctacagcagc
     1321 tgctggaacg tgcgctgacc ccactggtgg acgaagtgaa gcagaagggt ctggctcctg
     1381 cctgccccag ttgccagagg ctacacaaga agattctgga gctggagcgc caggccttgg
     1441 ccaaacacgt cagggcagag gccctgagct ccacccttcg gctggcccaa gacgaagccg
     1501 ttcgggccaa gaacctactg ctgacggaca agatgaagcc ggaggagaag gtggccactt
     1561 tggactatat gcatttgaag atgtgttccc tccacgacca actcagccac ctgccacttg
     1621 aggggtccac aggggcaatg gggggaggaa gcactggagg ggctccccct aaacgtgggg
     1681 gtccaggctc tgaacaataa atggcctctc atgctggcat gaa
//
LOCUS       NM_001437470            2495 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus GRAM domain containing 2B (Gramd2b), transcript
            variant 4, mRNA.
ACCESSION   NM_001437470
VERSION     NM_001437470.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77421.1,
                                           SRR26360181.651196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000018.1  52143177-52143295
            120-239             JAXUCZ010000018.1  52149457-52149576
            240-351             JAXUCZ010000018.1  52153538-52153649
            352-418             JAXUCZ010000018.1  52155530-52155596
            419-522             JAXUCZ010000018.1  52157431-52157534
            523-618             JAXUCZ010000018.1  52160835-52160930
            619-690             JAXUCZ010000018.1  52163592-52163663
            691-771             JAXUCZ010000018.1  52163752-52163832
            772-883             JAXUCZ010000018.1  52167125-52167236
            884-1006            JAXUCZ010000018.1  52167894-52168016
            1007-1094           JAXUCZ010000018.1  52169053-52169140
            1095-1199           JAXUCZ010000018.1  52170384-52170488
            1200-1293           JAXUCZ010000018.1  52175620-52175713
            1294-2495           JAXUCZ010000018.1  52178855-52180056
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11-q12.1"
     gene            1..2495
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain containing 2B"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
     exon            1..119
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    97..99
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="upstream in-frame stop codon"
     exon            120..239
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            240..351
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            352..418
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1335
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="isoform 4 is encoded by transcript variant 4; GRAM
                     domain-containing protein 3; GRAM domain-containing
                     protein 2B; GRAM domain containing 3"
                     /codon_start=1
                     /product="GRAM domain-containing protein 2B isoform 4"
                     /protein_id="NP_001424399.1"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
                     /translation="MHFHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSENWICFH
                     SKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLLK
                     SICGHLENTSVGNSPNPSSAENSFRADRPSSLRLDFNDEFSDLDGVVQQRRQDLEGYS
                     SSGSQTPESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGKAKILPAHGQSE
                     TIGILHKMESRKCPTLRHILIFYAIIVCALIISTFYMRYRINTLEERLGSLTSIMDPH
                     STEQTAPSSLGSQVQLNVEVLCQELTANIVTLEKIQNNLQKLLENGD"
     misc_feature    400..678
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     misc_feature    400..678
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     exon            419..522
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            523..618
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            619..690
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            772..883
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1006
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1094
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1199
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1293
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2495
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgctcc tggcttcctt tggatgaaga tgtagaactc ttagttcttc cagcgccatg
       61 cctacctgga tgaggccatg cttcctgcca tgatgataaa ggactgaatc tctgaacctc
      121 tcagaggctg agaatggcgt ggaagacaga aagaggttca gcaagtcgcc aacagcccaa
      181 tctcctacct catctgtgga ggccgagtcc ccggaccaga agagaagcct cggtctgtgg
      241 tcaaaatcca gttttgatgg ctccaatttg ttgagcgata agaatgactg taaaaccgaa
      301 agcaaggctg actctaagac cgaaagaaaa aagtcttcct cctccagcca gtacaaggca
      361 aacatgcact ttcacaagct attccttgat gtcccaaccg aggagcccct gagacaaagc
      421 tttacctgtg ctctccagaa agaaattctg taccaaggaa agctctttgt gtcggaaaac
      481 tggatttgtt ttcattccaa ggtctttgga aaagacacta agatctctat cccagccttt
      541 tcggtaacct tgatcaagaa aaccaaaact gcccttctgg tgccaaatgc cctgatcata
      601 gcgacggtca cagacaggta catattcgtt tccttgctgt ccagagactc aacctacaaa
      661 ctgctaaaat ctatttgcgg acacttagag aacacaagtg tcgggaacag tcccaaccca
      721 tcttctgctg aaaatagctt ccgggcagat cgcccttcct ctctgcgtct ggatttcaat
      781 gatgaattct cagacctgga cggagtggtt caacaacgaa ggcaagactt ggaaggatac
      841 agcagttccg gctcccagac tccagaatct gagaactctc gagacttcca tgtgaccgaa
      901 tctcagacag ttctgaatgt cacaaaggga gaaacaaaac cacctcggac agatgcccac
      961 gggagcagag cgcctgatgg aaaagccaag atcctgcctg cccatggtca atcggaaact
     1021 attgggattt tacataaaat ggagtctcgg aagtgtccaa ctctccgtca tatccttata
     1081 ttctacgcca ttattgtctg tgcgttgatc atctccacct tctacatgag atacaggatt
     1141 aacactctgg aggagcgcct ggggtccttg acgtccatca tggatcccca cagtactgag
     1201 cagacagccc cctccagcct aggatcacaa gtacagttaa atgtggaggt cctctgccaa
     1261 gaacttacag ctaacatagt gacattagaa aagatacaaa acaacttaca gaagctgctt
     1321 gagaatgggg actgagtgac cagctgctgg ggccaacata atacctcacg ttctcccttg
     1381 aagaaggtgc ttctcgagag tctgttgtgc gccccctgct ggccagaggc gcaagatgct
     1441 gagaatccag atgtgtttgc gcttggaggt ctccagctca ggaagggggg aggggaatga
     1501 gtttgctttc gtgcaataaa agttgacctt gtctctgctg ctgcctgaag ataacagacc
     1561 catctcggga ggtgagcaag gtcctggagg acacctgtaa cactcgggtt atggtaacat
     1621 cagtaaacac agcactccac gcttgtcagc tctttctcag ccattgctgc cttcacccac
     1681 accaatcagc cttcagacct aaggggaggt acactgtata ccaccaaact caaaatggtc
     1741 ctttagagaa ttagtcacga gcctccaaca aggtggtgaa tctctctcaa tgagcaggct
     1801 tgcttctgac accttcacgt ttgtggtttt gtttttgttt tcgtgttccc ttctactctt
     1861 atgttctggt ttctttcatc tgtgccttta aattttccaa ttcggttggg tgagcatgtc
     1921 cggtaaagtg aattaaatgt cccatctgtg ttgtgctgtc ttgcgcctgt gactagtacg
     1981 taattggagt gattctcccc aacctcccgt caggaatctt tgaggtgtga cattgaaata
     2041 ctaaatcaga ttcgctctga aaccaaaact aatctttcag cccaaagctg tcctagaaat
     2101 gtaatatggg aaggaaagcc ccgttcctgg ggttgtaagt gcagtgggag ctttgaagca
     2161 ggatgtctgt gttggactct aaaacccatt tcagcatggt aattggatgt ctttctccta
     2221 caataaagcg taagtggtgg tctgctaact ttacttacag tatgggttgg ctggttttta
     2281 ttaataatga tttagggtac cataagatct gtaagtataa aacattctat ctgcgatgca
     2341 ttttataatc atttctatga aatgtatttt gtttaatcag agaagctaat aagcggattg
     2401 gccgtgtcat gtgtattggt ctgcgtattg ggtaactgtg cctggtgcac ccccggcttt
     2461 taataaatac tcattgccta aggcacccta gttaa
//
LOCUS       NM_001437458            1755 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 15, mRNA.
ACCESSION   NM_001437458
VERSION     NM_001437458.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2067184.1,
                                           SRR26643293.2974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-626             JAXUCZ010000001.1  104572249-104572332
            627-913             JAXUCZ010000001.1  104572931-104573217
            914-1108            JAXUCZ010000001.1  104574234-104574428
            1109-1282           JAXUCZ010000001.1  104574810-104574983
            1283-1418           JAXUCZ010000001.1  104576616-104576751
            1419-1575           JAXUCZ010000001.1  104577708-104577864
            1576-1755           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1755
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1547
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 15 is encoded by transcript variant 15;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     15"
                     /protein_id="NP_001424387.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKL
                     EAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQK
                     VSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSA
                     RGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHV
                     LNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHK
                     KILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPE"
     misc_feature    135..1544
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..1544
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..626
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..913
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1108
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1282
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1575
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1755
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 aggagaactg ccgcaaggtg acccgttcag tggaagacgc tgaaatcaaa accaatgtcc
      601 tgaagcagaa ctctgccttg ttggaggaga agctaagata cctccagcag caactgcagg
      661 atgagacgcc ccggagacag gaggccgagt tgcaggagct ggagcaaaaa ctagaggctg
      721 gcctctcccg gcatggccta ggccctacta ctcccattca gggctgctcc ggtcctcctg
      781 gtagcccgga ggaacccccg cggccgcgag gcctgccctc caatggctgg ggcatggcaa
      841 tccgcgcagg ggagggaccc tcgctgagcg agcaggagtt gcagaaggtc tccagcggcc
      901 tagaggagct gaggagggag gtgtcctcgc tggcagctcg gtggcatcag gaggaggggg
      961 cggtgcagga ggccctaagg ttgctgggag gcctgggcgg ccgtctggat ggctttctgg
     1021 gccaatggga gcgggcgcag cgggaacaag cacagtccgc acggggtttg caggagctgc
     1081 gaggacgagc agatgagctg tgcactatgg tggagaggtc agcagtgtct gtcgcttcac
     1141 tgaggagcga actggaggca ctgggcccag taaaaccgat tctggaggag ctgggacggc
     1201 aacttcaaaa ctcccgaagg ggacctgacc atgtcttgaa cttggatcgt cctgcccaag
     1261 gtccctgtcc tcgatgtgcc agccaggggc agcagttatc cacggagtcc ctacagcagc
     1321 tgctggaacg tgcgctgacc ccactggtgg acgaagtgaa gcagaagggt ctggctcctg
     1381 cctgccccag ttgccagagg ctacacaaga agattctgga gctggagcgc caggccttgg
     1441 ccaaacacgt cagggcagag gccctgagct ccacccttcg gctggcccaa gacgaagccg
     1501 ttcgggccaa gaacctactg ctgacggaca agatgaagcc ggagtgagga cggaggcaga
     1561 gggcatggga ggaggggaga aggtggccac tttggactat atgcatttga agatgtgttc
     1621 cctccacgac caactcagcc acctgccact tgaggggtcc acaggggcaa tggggggagg
     1681 aagcactgga ggggctcccc ctaaacgtgg gggtccaggc tctgaacaat aaatggcctc
     1741 tcatgctggc atgaa
//
LOCUS       NM_001437478            3453 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 7, mRNA.
ACCESSION   NM_001437478 XM_063277306
VERSION     NM_001437478.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3453)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3453)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3453)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3453)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3453)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3453)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3453)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3453)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277306.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1909050.1,
                                           SRR26643289.41435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000018.1  48404817-48404860
            45-147              JAXUCZ010000018.1  48472546-48472648
            148-220             JAXUCZ010000018.1  48485845-48485917
            221-1089            JAXUCZ010000018.1  48504584-48505452
            1090-1269           JAXUCZ010000018.1  48507187-48507366
            1270-1383           JAXUCZ010000018.1  48514668-48514781
            1384-1509           JAXUCZ010000018.1  48523111-48523236
            1510-1679           JAXUCZ010000018.1  48526537-48526706
            1680-1772           JAXUCZ010000018.1  48532075-48532167
            1773-2826           JAXUCZ010000018.1  48532658-48533711
            2827-3453           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3453
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..44
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..147
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             91..2832
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 2 is encoded by transcript variant 7;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 2"
                     /protein_id="NP_001424407.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAA"
     misc_feature    <1051..1614
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1051..1614
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1132..1134,1138..1140,1150..1155,1162..1170,
                     1174..1179,1189..1191,1204..1206,1231..1233,1237..1239,
                     1243..1245,1360..1365,1372..1380,1384..1389,1399..1401,
                     1420..1422,1447..1449,1453..1455,1459..1461,1471..1476,
                     1483..1491,1495..1500,1510..1512,1519..1521,1546..1548)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1132..1134,1138..1140,1150..1155,1162..1170,
                     1174..1179,1189..1191,1204..1206,1231..1233,1237..1239,
                     1243..1245,1360..1365,1372..1380,1384..1389,1399..1401,
                     1420..1422,1447..1449,1453..1455,1459..1461,1471..1476,
                     1483..1491,1495..1500,1510..1512,1519..1521,1546..1548)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1132..1233
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1132..1233
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1237..1449
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1237..1449
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1453..1548
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1453..1548
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1621..1752
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1621..1752
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            148..220
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1089
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1269
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1383
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1509
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1679
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1772
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2826
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3453
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcctgcgg gaaagagcca aggcggcgga ggtgaacgcg cgaggatatt ataaatattc
       61 gaccttactc aaaatgtaca aagaagaata atggaagccc ctgaatatct tgatctggat
      121 gaaatcgact ttagtgatga catttcttat tcagtcacat ctctcaagac catcccagca
      181 ctgtgcagaa gatgtgactc acagaacgaa gacagaccag tttctagctc tagctggaat
      241 tgtggtgtct caactctcat tacaaacccg caaaagccca ctggaatcgc tgatgtatac
      301 agtaagttcc gcccggtgaa gcgagtttct ccactgaaac atcagccaga gactctggag
      361 agcaatgaaa gtgacgacca gaagaacaat acagtggaat accagaaagg gggggagact
      421 gaccagggcc cccagcctga ggagctcagc cctgaagatg gagtcggagg cttgccaggc
      481 aagggctcag agcccagcca ggcactgggt gagctggagc actatgacct cgacatggat
      541 gagattctgg atgtgcctta cattaaatcc agtcaacagc tggccccgct caccaaggtg
      601 acttcagaaa aaaggatttt gggtttatgc acaactgtca atggcctctc tgccaaaacc
      661 tgccctattg taagcgctga gacctccaca cccaacatgg ctccattgtg tgttctttct
      721 cctgtgaaaa gccctcactt acggaaagta cccagtgtcc tccgggacca gcacaagctc
      781 cctgcggaag aatcggagaa ctcacccgct cctggtaaat gcggccctgc atttgaatca
      841 gaaaaccaca gtaaggactt cttaaacaag gtctttagtg atccccatag tcggaaagct
      901 gagaagtctg ggccagactg caagctcagg cccttccgcc tgcagacctc ggcagcagga
      961 gccaaaccag aggagcaggt caacggcgtg agctgggcca gtgcccaagg cgcagaagaa
     1021 aggactgagt acctgcagaa agtaagaagc atactgaaca ttgtgaacga agggcagata
     1081 tcgctcttgc cacacctagc tgcagataat ctggacaaaa ttcacgacga gaacggaaac
     1141 aatctgttac acgttgctgc atcaaagggc catgcggaat gtctgcagca cctcacgtcg
     1201 ctgatgggcg aagactgtct gaatgaacgg aacgcagagc aactgactcc agcgggcctg
     1261 gccatcaaga atggtcagct ggagtgtgta cgctggatgg tgagtgagac ggaagccatt
     1321 gcggaactga gttgttccaa ggatttccca agcctaattc attacgcagg ctgctatggg
     1381 caggaaaaga ttcttctgtg gcttcttcag ttcatgcaag aacaaggcat ctcattggat
     1441 gaagtagatc aggaaggcaa cagtgctgtt catgtcgctt cacaacatgg ctaccttgga
     1501 tgcatacaga ccctggtgga gtatggagca aatgttacga tgcagaacca cgctggggaa
     1561 aagccctccc agagtgccga gcggcacggc cacaccctat gttcccggta cctcgtggtg
     1621 gtagagacct gtatgtcact ggcctcacaa gtggtaaagt tgaccaagca gctaaaggag
     1681 cagacagtgg agcgcgtcac actgcagagt caactccaac aacttctgga agcccagaaa
     1741 tcagagggca agtccctccc atcttcaccc agttcaccct cctcaccagc ttctagaaag
     1801 tcccagtgga aaattctaga tgcagatgac gagtctacag gcaaaagcaa actgggaacc
     1861 caggagggaa tacaagtcct tggaaactta tccagcaggg ctaggaccaa aggaaaagac
     1921 gaagactctg ataaaatcct acgtcagtta ttggggaaag aaatatcaga gaatgtctgc
     1981 acccaggaaa agctgtcatt ggaattccag gatgctcagg tatcctctag gaattcgaaa
     2041 aaaatacctc tagagaagag ggaactgaag ctagctagac tgcggcagct gatgcagaga
     2101 tctttgagtg aatctgacac ggattcaaac aactctgagg accccaaaaa tactcctgtg
     2161 aaaagagtgg acagacctag accacagccc attgtggaaa gtgtggagaa tatggacagt
     2221 gcagaaagct tacacctgat gataaagaaa cactctgtgg catcaggacg caggtttcct
     2281 tttggtatga aggcctccaa atccctggat gggcacagcc catctcccac ttcagagagc
     2341 agtgaaccag atttggactc ccattgcccg agcctgggaa tgactcctcc aacccaacct
     2401 tctacagaag ccactcagtg cagtcctgac agtgccactg cccagaaagt tgctacaagc
     2461 cccaagagtg ccctcaagtc tccatcatcc aagcgccgga catcccaaaa ctcaaaactg
     2521 agagtgacct ttgaggagcc tgttgtgcaa atggagcaaa ctagccttga actaaatgga
     2581 gaaaaagaca aagagagggg cagggccccc cagaggacta gtgagtcagg agaacaaatg
     2641 aaaaggcctt ttggaacctt ccgatccatc atggagagtt taagtggtaa tcagaacaac
     2701 aataataact accagccagc cagccagctg aagacctgca cactaccctt gacgtcactt
     2761 ggaaggaaga cagcagatgc caagggaaac cctgtgagcc ctgctagcaa aggaaagaat
     2821 aaggcagctt aatgacatca aaagaaacac gaagaaaact tacaacgtaa agcacattgc
     2881 tgaaccagag ccaaaggaac tcttcttata aattactctt agtatgagtc tcacacatgc
     2941 cctctggcca ccattgggag ttaatggact gtggcaatca gaccatgaga acaacacctc
     3001 accagcgagc agaatatctg gatgccttaa atttataata tgagacttgt tataagatac
     3061 attttggacc atatctgtac atagaacttg tttgatttct tttttaatat gctgtttgaa
     3121 aacatgatcg ggcaatgtat gcattgacac attggacatt tgattgagtc gaccttcttg
     3181 aagcacatcc accagcacct gacacgacta gtgtttttgt gaattgcatg aggatttgct
     3241 gatgttgatt agatgttcac cttctttgta acaagggcag ctgtggctca gctcagtgag
     3301 gccaggtcac tggttttatt ttctgtccag tgtgtttttc tgtcatttct acttttttaa
     3361 taaagaaaat taaacatttg taacagcaga ctctgggcgt ggggggcagg gcatctactt
     3421 tctaataaat ctgtgaagct ctgatttcta aaa
//
LOCUS       NM_001437435            1970 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Ras and Rab interactor-like (Rinl), transcript
            variant 4, mRNA.
ACCESSION   NM_001437435 XM_063283399
VERSION     NM_001437435.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063283399.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2099835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  93204794-93204825
            33-155              JAXUCZ010000001.1  93206409-93206531
            156-315             JAXUCZ010000001.1  93206696-93206855
            316-418             JAXUCZ010000001.1  93209713-93209815
            419-491             JAXUCZ010000001.1  93211848-93211920
            492-556             JAXUCZ010000001.1  93212006-93212070
            557-703             JAXUCZ010000001.1  93212633-93212779
            704-1180            JAXUCZ010000001.1  93212866-93213342
            1181-1468           JAXUCZ010000001.1  93213660-93213947
            1469-1632           JAXUCZ010000001.1  93214371-93214534
            1633-1970           JAXUCZ010000001.1  93214620-93214957
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1970
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     exon            1..32
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            33..155
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1677
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="isoform 3 is encoded by transcript variant 4; ras
                     and Rab interactor-like protein"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein isoform 3"
                     /protein_id="NP_001424364.1"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
                     /translation="MRLAQPDMVSAATTEEARLSWPLAEGADKSPLRVLSTTESLLRL
                     QRTQRVWQVPELDAEHAKAFLKPWPLGSFLVIGQDPDQVLMLKTGPSSGDINTYQIQK
                     FPGGVSLESSNLCMPDFPHLLAFLSASRDVLPRTLLLPTPTVGPGDKHSDPRRLGCIQ
                     VDTSGRVLSVVNQLYLETHGGWETETPQQTKPETGQKRSLAPRMPTPHRVSWVEESLK
                     PEAHHTGQEVHHPERQVHYPGPEAHSLGPEVHFPSPVLEEEEEVNNDSYKDEEEGCED
                     MLTAHIRALASARSSYVARQYQCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQD
                     YLAKDPDVRAVFGNRGPSIPREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELR
                     RLRRRQIALRVGAGPEGQSPALRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLA
                     GGENKAGYYLTTWFGALYHIAHYQPDAGRAPQELSSEARASLRQWHRRRTLHQQAQPT
                     APENQPFEEPWAIGDP"
     misc_feature    229..510
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    229..510
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    order(274..276,328..330,391..393,397..399)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198256"
     misc_feature    order(274..276,328..330,391..393,397..399)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198256"
     misc_feature    order(394..396,475..477)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198256"
     misc_feature    order(394..396,475..477)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198256"
     exon            156..315
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            316..418
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            419..491
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            492..556
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            557..703
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1180
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1468
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1632
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1970
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct gctcaggctc ccctcggaac agctggagca gccttgagtc ttgtcttcct
       61 ccatgccaga ggccaaagca tggctcactg gtgcctggca gcatgaggct agcccagccg
      121 gacatggtgt ctgcagccac tactgaagag gccaggctga gttggccact agcagaagga
      181 gcagacaaga gcccactgag ggtcctcagc acgacagagt cacttcttcg actgcagagg
      241 acacagaggg tgtggcaggt ccccgagctg gacgctgagc atgccaaggc ctttctcaag
      301 ccgtggccac tggggagctt cctggtcatc gggcaggacc ctgaccaggt cctgatgttg
      361 aagacaggac cttcgtcagg agatatcaac acctaccaaa ttcagaagtt tcctggaggt
      421 gtgtccctgg aatcctccaa cctctgcatg ccagactttc ctcatctcct ggcctttctg
      481 tcagccagca gggacgtttt gccaaggact ctgctcttgc ccacacctac tgtggggcct
      541 ggagataagc actcagatcc tcgtcgactt ggctgcatcc aggtggacac ctcagggagg
      601 gtgctgtctg tggtgaacca gctctacctg gagacccatg gaggctggga aacagaaaca
      661 ccgcagcaaa caaagccaga aactggccag aaacgcagtc tagcccccag gatgcccact
      721 ccacaccggg tctcctgggt ggaagagtct ctgaaaccgg aagctcacca tactggacag
      781 gaagtgcatc atccagaaag acaagtgcat tatcctggac cagaagctca ctctcttggg
      841 ccagaagtac actttcctag tcctgttcta gaagaggagg aagaagtgaa caatgacagc
      901 tacaaggatg aagaggaagg ctgcgaggat atgctcactg cccacatccg tgctctggcc
      961 agtgcccgga gcagttatgt agccaggcag taccaatgcc ttcgagcacg actcatctca
     1021 gattctggaa atccctacag cccaggggac ccagccacag agctgcttca ggatgtacgc
     1081 cagctcctca ctgacctcca ggattacctg gcaaaagacc ccgatgtcag agctgtcttt
     1141 gggaataggg gacctagcat ccctcgggaa gaagatcttg gccccgctgt ggaggtggcc
     1201 ctgtgtcgag cggttctgga gcccctgaag cccgccctgt ggaccaaact ccgaactctc
     1261 agagcccagg aactgcggcg actgcgccgg cgccaaatag ccttgagggt aggagcagga
     1321 cccgagggac agagcccggc cttgcggaac cgtatccacg cacgcctcgc tcacctgcac
     1381 gcagcgtgcg ccccgcgccg caaggtggcg ctgttgttgg cggtgtgcag cgatgtctat
     1441 gcaggcctgg ctggcggcga gaataaagct gggtattatc ttaccacgtg gtttggggct
     1501 ctctaccaca ttgctcacta ccagcctgat gctggccgtg caccccagga gctcagctct
     1561 gaggcccggg cctccttgcg ccagtggcac cgaagacgga cactgcacca gcaagcccag
     1621 cccacagccc cggaaaacca gccctttgag gagccatggg caatagggga cccatgatga
     1681 ttggagtcct caaaaatcag tctccagaac cttttggccc actcctctgc taagcaagat
     1741 tctggaggca tctgggtcag cacagtgggt ggggcagaaa aaaggacgtg gcgttttgca
     1801 ctggctgttc ctacttcctt ccttcccctc ctggtctgtc cacatgttac ctcaatgagg
     1861 ctctccccag caaacaaaac caacgcctaa acaatactac aactacagcc ctctcacctg
     1921 aatctctctg gggcaggtag aataaaggca cagtccccaa aaggtatcta
//
LOCUS       NM_001107847            7888 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus golgin A3 (Golga3), transcript variant 2, mRNA.
ACCESSION   NM_001107847 XM_001078840 XM_231418
VERSION     NM_001107847.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7888)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7888)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 7888)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
REFERENCE   4  (bases 1 to 7888)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   5  (bases 1 to 7888)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   6  (bases 1 to 7888)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001107847.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.41750.1,
                                           SRR26643294.47062.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000012.1  52159888-52159934   c
            48-366              JAXUCZ010000012.1  52155150-52155468   c
            367-516             JAXUCZ010000012.1  52152769-52152918   c
            517-629             JAXUCZ010000012.1  52149148-52149260   c
            630-1276            JAXUCZ010000012.1  52147114-52147760   c
            1277-1388           JAXUCZ010000012.1  52145672-52145783   c
            1389-1695           JAXUCZ010000012.1  52143096-52143402   c
            1696-1898           JAXUCZ010000012.1  52139848-52140050   c
            1899-2036           JAXUCZ010000012.1  52139109-52139246   c
            2037-2198           JAXUCZ010000012.1  52136241-52136402   c
            2199-2567           JAXUCZ010000012.1  52135506-52135874   c
            2568-2645           JAXUCZ010000012.1  52133802-52133879   c
            2646-2909           JAXUCZ010000012.1  52132623-52132886   c
            2910-3004           JAXUCZ010000012.1  52131526-52131620   c
            3005-3221           JAXUCZ010000012.1  52129845-52130061   c
            3222-3365           JAXUCZ010000012.1  52128948-52129091   c
            3366-3563           JAXUCZ010000012.1  52127867-52128064   c
            3564-3680           JAXUCZ010000012.1  52125433-52125549   c
            3681-3820           JAXUCZ010000012.1  52120961-52121100   c
            3821-3953           JAXUCZ010000012.1  52120173-52120305   c
            3954-4076           JAXUCZ010000012.1  52119896-52120018   c
            4077-4238           JAXUCZ010000012.1  52117567-52117728   c
            4239-4402           JAXUCZ010000012.1  52116696-52116859   c
            4403-7888           JAXUCZ010000012.1  52112129-52115614   c
FEATURES             Location/Qualifiers
     source          1..7888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..7888
                     /gene="Golga3"
                     /note="golgin A3"
                     /db_xref="GeneID:312077"
                     /db_xref="RGD:1305262"
     exon            1..47
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            48..366
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="Golga3"
                     /note="upstream in-frame stop codon"
     CDS             231..4574
                     /gene="Golga3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Golgin subfamily A member 3; golgi autoantigen, golgin
                     subfamily a, 3"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 2"
                     /protein_id="NP_001101317.1"
                     /db_xref="GeneID:312077"
                     /db_xref="RGD:1305262"
                     /translation="MDGASAKQDGLWENKSSSDISSCPEASLETVGSLAQLPDQQDTA
                     QDGSVEVNRVFKEEGSPDRSSQVPICQNGQIPDLQLSLDPTTSPVGPDASTGSTASSL
                     PLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPR
                     ASAVAVTKEYSFLRTSVPRGPKVGSLGLLAHSKEKKNSKSSKIRSLADYRTEDPSDSG
                     GLGSTADAVGSSLKQSRSSTSVVSEVSPSCETDNRAESASLAGDSVSEADGNESDSSS
                     HSSFSARGACAVLGNVGTPGAAYVVDGQEISAEALGQFPSIKDVLQAAAAQHQDQNQE
                     ANGEVQSRRDSICSSVSMESSFAEPQEELLQILKDKRRLEGQVEALSLEASQALQEKA
                     ELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAK
                     NASLASSNNDLQVAEEQYQRLMAKVEAMQRNILSKDNTVHDLRQQMTALQSQLQQVQL
                     ERTTLTSKLQASQAEITSLQQARQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLL
                     EHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEE
                     DLQRKLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQL
                     TSTQEALQAKGQSLDDLQTRYDELQARLEELQREADSREDAIHFLQNEKIVLEVALHS
                     ARSDKEELDRGARRLEEDTEETSGLLEQLRQDVAVKSNQVEHLQQETATLRKQMQKVK
                     EQFLQQKVMVEAYRRDAASKDQLINELKATKKRLDSEMKELRQELIKLHGEKKTVEVE
                     HSRLQKDMSLVHQQMAELEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLKK
                     QIEELQQEAKKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALAN
                     KEATDAELNQLRAQSTGGSSDPALHEKIHALEVELQNVGQSKILLEKELQEVITMTSQ
                     ELEESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALR
                     EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQISLEKEKTEVSS
                     LKEQMAAARVEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQEGKHS
                     QEIAQFQTELAEARTQLQLLQKKLEEQRSQQPTGSQEMEDLKWELDQKEREIQSLKQQ
                     LDLTEHQGKKELEGTQQTLQTIKSELETVQEDLSETQKDKFMLQAKVSELKNNMKTLL
                     QQNQQLKLDLRRGAAKKKEPKGESSSSSPATPIKIPDCPVPASLLEELLRPPPAVSKE
                     PLKNLNSCLQQLKQEMDSLQRQMEEHTITVHESLSSWAQVEAAPAEHAHARGDTKVHN
                     QNSVPGEGLGQ"
     misc_feature    <1122..3068
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1122..3068
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2097..4163
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2097..4163
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            367..516
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..629
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1276
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1388
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1695
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1898
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2036
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2198
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2567
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2645
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2909
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3004
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3221
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3365
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3563
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3680
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3820
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3953
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4076
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4238
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4402
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..7888
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcacggc cacgtcctac cggagccgca gggttgggcc gctacgggaa tcatggtatt
       61 gcttggtttg acttcaagcc atttatgaga ctttaaacct taccctgaaa atggaaaaca
      121 gagtaagatc cttcttagaa gctctgagct gttgctgatg gcaaaaagca aacttaatcc
      181 agagttacct gtagctcctc agagtcttct tagtctgggc tgccctgacc atggatggag
      241 catcagccaa acaggatggc ctctgggaaa acaagtctag cagtgatatt tcatcttgcc
      301 ctgaagcctc actggaaact gtgggctctt tggcccaact gcctgaccaa caagatacag
      361 ctcaggatgg cagtgttgag gtaaacagag tttttaagga agaaggaagc ccagacagat
      421 ccagccaggt gcccatctgt cagaatgggc agatcccaga ccttcagttg tctcttgatc
      481 ccacaacaag cccagtggga cctgatgcct ctacaggctc tactgcatct tcactgccct
      541 tggaaaagga ggagcaggtc cgactgcagg cccggaagcg cctggaagag cagctgatgc
      601 aataccgagt taagcgccat cgggaaaggt ccagtcagcc ggcaactaaa atgaaacttt
      661 ttagtacact tgatcctgag ctcatgttaa atccagaaaa cttgccaagg gccagtgctg
      721 tagctgtgac aaaagaatat tccttcctgc gtaccagtgt tcctcggggg cccaaggtag
      781 gcagcttagg gctgctggca cattctaaag agaagaagaa ttccaagtca agcaagattc
      841 ggtctctggc tgactataga actgaagatc caagtgactc tggtggcctt ggttctactg
      901 ctgatgctgt tggaagttcc ctgaaacaga gtagaagtag cacttcagtt gtgtctgaag
      961 tgagcccatc atgtgagact gataaccgtg cagagagtgc ctcactggct ggggacagtg
     1021 tgtcagaggc tgatggaaat gagagtgaca gttcctcaca cagcagcttc tctgcccgag
     1081 gggcctgtgc tgtcctgggg aatgtcggca caccaggagc agcttacgtg gttgatggcc
     1141 aggagatttc tgctgaggcc ctgggccagt ttccttcgat taaagacgtg ctacaggctg
     1201 cagcagccca gcaccaagat cagaaccagg aagccaatgg ggaggtgcag agccgcagag
     1261 acagcatctg cagcagtgtg tccatggaga gctcttttgc tgaaccacag gaagaattgt
     1321 tgcagatcct taaagataag aggagacttg aaggacaggt ggaggctttg tcattagaag
     1381 ccagtcaggc acttcaagag aaggctgagc tacaggccca gcttgctgcc ctgagcacaa
     1441 ggctacaggc acaggtggaa cacagtcaca gcagccagca gaagcaagac tcccttagtt
     1501 ctgaagtgga cactttgaag cagtcttgct gggatttgga gcgggctatg actgacctgc
     1561 agaacatgct agaagctaaa aatgccagcc tggcatcgtc aaacaatgac ctacaagtgg
     1621 cagaggagca gtatcagaga ctgatggcca aagtggaggc catgcagaga aacatcctta
     1681 gcaaggacaa cacagttcat gacctgcggc agcagatgac agcgctacag agccagctcc
     1741 agcaagtaca gctggagcgc acaacactga ccagcaaact acaagcatca caggctgaaa
     1801 tcacttcttt gcagcaggcc cggcagtggt accaacagca gcttgctttg gcccaggagg
     1861 ccagagtcag gctgcaagga gagatggccc acatccaggt cggacagatg actcaagcgg
     1921 gccttttgga gcacctgaaa cttgagaatg tgtccctatc gcatcagcta acagaaactc
     1981 agcacagatc catcaaggaa aaagagcgca tagctgttca gctccagagc attgaggctg
     2041 acatgttaga tcaggaggca gcatttgtac agattcggga ggcgaagaca atggtggaag
     2101 aagacctcca aaggaagctg gaagaatttg aaggtgaacg ggaacagtta cagaaagtgg
     2161 cggatgcagc agcgtccctg gagcaacagt tggaacaggt gaagttgaca ttgttccagc
     2221 gagatcagca gctggcagca cttcagcagg agcatctaga tgtgataaag cagcttacat
     2281 cgacacagga ggctctacag gccaaagggc agtccctcga tgacctgcaa acacgttatg
     2341 atgagctaca agcaaggctg gaagagctgc agagagaggc tgactccagg gaggatgcca
     2401 ttcacttctt gcagaatgag aagattgtct tagaagtggc tctgcactca gccaggagtg
     2461 acaaggagga acttgacaga ggagcacggc gtttggaaga agatactgag gagacatcag
     2521 gacttttaga acaattgaga caagatgtgg ctgtcaagtc caaccaggtg gaacacttgc
     2581 agcaagagac agccacattg agaaaacaga tgcagaaagt aaaggagcag tttcttcagc
     2641 aaaaggtgat ggtagaggcc tatcggcgag atgctgcttc taaagaccaa ctcatcaatg
     2701 agctgaaagc taccaaaaaa cgcctggact cagagatgaa ggaactgagg caggagctga
     2761 tcaagctgca tggagagaag aagactgtgg aagtagagca ctcacggctg cagaaggaca
     2821 tgtccctggt tcaccagcag atggcagagc ttgaggggca tctccagtcg gtgcagaaag
     2881 agcgagatga aatggagatt cacctgcagt ctttgaagtt tgacaaagag cagatgatag
     2941 cccttactga ggccaatgag acactaaaga aacaaataga ggagctgcag caagaggcca
     3001 agaaggccat cacagaacag aagcagaaga tgaagcggct gggctcagat ctgaccagtg
     3061 cccagaagga gatgaagact aagcacaagg cttacgagaa tgctgtgagc attctcagcc
     3121 gtcgcctaca ggaggctctg gctaacaagg aggccacaga tgcggagctg aaccagctca
     3181 gagctcagag cacaggtggc agcagtgacc ctgctctaca tgagaagatt catgctctgg
     3241 aggtggaact gcagaatgtt ggccaaagca aaatactgct ggagaaggag ttacaggagg
     3301 tgatcacgat gactagccag gagttggaag agtcccggga gaaggtgctg gagctcgagg
     3361 atgagcttca agaatccaga ggcttcagaa ggaagataaa acgtcttgaa gagtcaaata
     3421 agaagctagc tctggagtta gaacatgagc gagggaagct caccggcctt ggacaatcta
     3481 atgcggcttt gcgggagcac aacagcattc tggaaactgc actagccaag agggaagctg
     3541 acctggtgca gctgaatctc caggtgcagg cagttttaca gcgcaaagag gaggaggatc
     3601 gccagatgaa gcaacttgtc caagccttac aaatctcatt agagaaagaa aagacggaag
     3661 tgagcagcct gaaggaacag atggctgctg ccagggtaga agctgggcac aaccgccgcc
     3721 actttaaggc agcgactttg gagctgagtg aggtgaagaa agaattgcag gccaaagaac
     3781 acctggtaca gacactgcag gccgaggtgg atgagctcca gattcaggag ggaaagcatt
     3841 ctcaagaaat cgctcaattc cagactgagc tggcagaagc taggacccag ctccagctcc
     3901 tgcagaagaa gctcgaagaa cagaggagcc agcaaccaac agggagccaa gagatggaag
     3961 atctcaaatg ggaattggat cagaaagaac gagagattca gtccctgaag cagcagcttg
     4021 acttgacaga gcaccagggc aagaaagaac tcgagggtac acaacagaca ctgcagacta
     4081 tcaagtctga gttggaaacg gttcaggaag atctgtctga gacccagaag gataagttta
     4141 tgcttcaagc caaagtgtct gaactgaaga acaacatgaa gactctgctg cagcagaacc
     4201 aacagctcaa gctggatctc cgccgcggtg cagccaagaa gaaagagcca aaaggtgagt
     4261 ccagctcatc cagtccagca acacccatca agataccaga ctgccctgtc ccagcctcac
     4321 tgctggagga gctgctgagg cccccacccg ctgtgagcaa ggagcccctg aagaatctca
     4381 acagctgttt gcagcagctc aagcaggaaa tggacagtct acagcgccag atggaggagc
     4441 ataccatcac tgtgcatgag tccctgtcct cgtgggctca ggtggaagct gccccagcag
     4501 agcatgccca tgcccgggga gacacaaaag tacacaatca aaacagtgtt cctggagaag
     4561 ggctgggcca atgaccactg ttgtccttat caccaagtat ttgtggctgt tgaaggaata
     4621 ctcttgtcaa tattatttat ttgattgaat gctctggtgg ctttcttttt ttttcgtttt
     4681 ttaagaaatt acttaaattt cccttcactt tttatcaagg attaaaataa caaacatctg
     4741 ggaggtggtg gcacacactt ttaatcccag cacccaggag gcagatgtag gcatgatctc
     4801 tatgagtttg aggccagcct ggtctacaga tcaatagttc cagaacagcc agggctacaa
     4861 agagagactc ttgtctcaaa ataaataaat aaagggatga ggcaagaatt aaaaacatag
     4921 tcatagcttt tcccatgaaa tgaccaattc ttaaaaacat cagagtttgg actgctggtg
     4981 aaatctgagt gtgtatatct gaacagtcac ttgcagaagg agagaacttc atgtgtggct
     5041 acagacacac ataagacctt tactttccta cataaatgag tttttattta caccttttgc
     5101 tttttatttc atttgccttt caaactattc tacctaaata ggatgtatat atataaatac
     5161 caaaagtctt ttgaaaacat acacctatgt tatttaagga tctaattgtt ttactactga
     5221 tttccctttg aaaatttgct actgggaaac agtatacatg tagctttagg ggtgtcagtt
     5281 taaaaatgta ttttaagaag tataacttat tttctatgca tcctaaaacc aaatactctt
     5341 ggcacagaaa gaattgtgtt agttttagtc ttttcatttc tgagggtctt ttctaccaac
     5401 atgtccatga attaataaca ctgacctttt aggtctgtgg ccttacgtgg ttttactcac
     5461 tttggcttac caacaggcag ggccagtcag gccttgaggt cagttagcag gggacaaaag
     5521 gacctccaag gtctcctcat actgacctga tatttggaga acactggtgg aggcagcctt
     5581 gggctgtggg ttataggctg caaacactgt gtcccaaaga tggtgtttat gaaacagtga
     5641 atgtctgtct gtgggcatca ggaaccacca tggacctcta ttgaatactt gtggcacaac
     5701 aagccagagt aatacctgga agaaggtagg caactttggt tttctgagac agggttaaaa
     5761 gacaaaagcc ttgtttaaag tcagcaccaa gtgtgtgatt tattgctgtc tgcttcccaa
     5821 atcataataa tatttacata gaacacctga cttgaggtct gtaatctttg tgaatgcttg
     5881 tgaagaaaat ttaaaataaa gtagattttt gatccatgac tgtaacccca gcacttggga
     5941 gatagaatca ggaggcgaat ctgttcaaga ctagttttca gctacacagc aagtttgagg
     6001 caagactggg ttacatgaac catgacttag aaagacagac aagctggaac aacaagagaa
     6061 acgatctgga acagtgttag aaggaaaagg gagaaagacc tgaaggaagc tgtaagcgtg
     6121 ttcagctagt tggtgtcttt gagtgggttt cttgtctatt ttatggaaaa tcagtatggc
     6181 atttttaatc tgtgttctct taaaatatcc tattagagcg gtaaatgatg tggttaaagt
     6241 agaattatca gcagtgatgt ctggtgtttg aaaaatattc tttagcaagt attgggactt
     6301 taaagtgtgt atatcacttg tacagggtta atcttaaaaa aatctttaaa acgttattgt
     6361 aaatataccc ttttattctc taagatagaa attagaaaaa gatggtaatt tacattattt
     6421 attttgtatt tttaatgtca aaaccaagaa atagctcttg gtttggactt actctgcaac
     6481 agagctagtt tctcctatgt aaagagatct tcaagtgagt tttgttgatt gtgttgtctg
     6541 gggaaggata agctaattct gaactcattc agatgaaggt tgttttcatg tcttaaccca
     6601 tttcttcggt tgctttgctg tcccatatgc acgtcccata tgtccctcag aaatgtcact
     6661 tcttctaaac tttgtagtct gccttgtgaa tccttggcta ggttcctttt ggttccatga
     6721 aaggtctgac atgtcttggc ttctttctct gtccctcttt gcatgtcaat gtgtcttttc
     6781 tcacagttgt gattcagagg actcttagat tggagccggg attctcttag ggctctttaa
     6841 gtcacattga agttgagttt tcaggttccc tttttttgtt tgtttgtttt gagtttttcc
     6901 cttctatttt tccctcttat ttctattgta cttcgcctcc ttgagcttat tcctgagtga
     6961 atatggcttg actactgttg cctctgcagc cagacctggg ggttttagtt tgctcatgaa
     7021 aaagtgcagg caggtatgga gaattgcttt ctcaggcggg ctcacaccat tgtgtaccat
     7081 ttctgcatat atcatatatg ctgaatcttg tcctatactg gacaccttgg cttgcatgct
     7141 ttatactatt agttttctta tgtttaaaaa ttaccatgaa atttctatct ttgtttctat
     7201 ggtagacgtc caattgatgc tgtgatttta gatttttata ccatggtagc aggcaatgat
     7261 tttgagagat gtgaggctga ctttacgtgg acgtgggata cagggagctc agaaggtaga
     7321 cttagtgcat atatcaaaaa gcttggttaa attcttctcc atttcaaaat aaactttcca
     7381 gtatgtggac actgtaaaag ccataggctt ataggtcaca atgatatata tttttcatat
     7441 attttgaaac aaaaattggc aggtgaagat tctggattta aaagggacca tcatatttga
     7501 aaagtcctgg aacctcagag gacccctgtg ataaaaataa tactgtggca tgagatatct
     7561 cgagtcttaa tctaacatgc tcagtagttt ggaaatctag cccagtctac tctgtagtgg
     7621 tcataggttc tgacaggatc tttgggtcca tgtacggttt ggagggtcca acatttcagt
     7681 gctttttgag tttctcattt ctataaaaag ttatcttaca agggagtcag tcttcatgtt
     7741 ggggctttcc cagggaaact gtcatcactg gtaacaaact gtaactttaa aaaggcatgt
     7801 tgttgctgtt attgttttgc cttctttttt taatataagt gtgcttggga actccttaca
     7861 ttttatgcaa taaactattt ttggtaaa
//
LOCUS       NM_001437461            1235 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus nitric oxide synthase interacting protein
            (Nosip), transcript variant 3, mRNA.
ACCESSION   NM_001437461 XM_063284173
VERSION     NM_001437461.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Yu,X., Zhong,Y., Zhu,Z., Wu,T., Shen,A. and Huang,Y.
  TITLE     Increased expression of nitric oxide synthase interacting protein
            (NOSIP) following traumatic spinal cord injury in rats
  JOURNAL   J Mol Histol 43 (6), 661-668 (2012)
   PUBMED   23135205
  REMARK    GeneRIF: Data suggested that NOSIP may play an important roles in
            astrogliogenesis after a spinal cord injury.
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1235)
  AUTHORS   Dreyer,J., Schleicher,M., Tappe,A., Schilling,K., Kuner,T.,
            Kusumawidijaja,G., Muller-Esterl,W., Oess,S. and Kuner,R.
  TITLE     Nitric oxide synthase (NOS)-interacting protein interacts with
            neuronal NOS and regulates its distribution and activity
  JOURNAL   J Neurosci 24 (46), 10454-10465 (2004)
   PUBMED   15548660
REFERENCE   4  (bases 1 to 1235)
  AUTHORS   Dedio,J., Konig,P., Wohlfart,P., Schroeder,C., Kummer,W. and
            Muller-Esterl,W.
  TITLE     NOSIP, a novel modulator of endothelial nitric oxide synthase
            activity
  JOURNAL   FASEB J 15 (1), 79-89 (2001)
   PUBMED   11149895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284173.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.2331.1,
                                           SRR26360181.2907997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  104679882-104679922
            42-194              JAXUCZ010000001.1  104688756-104688908
            195-366             JAXUCZ010000001.1  104691442-104691613
            367-472             JAXUCZ010000001.1  104692002-104692107
            473-554             JAXUCZ010000001.1  104692637-104692718
            555-714             JAXUCZ010000001.1  104693880-104694039
            715-833             JAXUCZ010000001.1  104694121-104694239
            834-1021            JAXUCZ010000001.1  104694338-104694525
            1022-1130           JAXUCZ010000001.1  104694601-104694709
            1131-1235           JAXUCZ010000001.1  104695015-104695119
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1235
                     /gene="Nosip"
                     /note="nitric oxide synthase interacting protein"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
     exon            1..41
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            42..194
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            195..366
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    264..266
                     /gene="Nosip"
                     /note="upstream in-frame stop codon"
     CDS             297..1202
                     /gene="Nosip"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="nitric oxide synthase-interacting protein"
                     /protein_id="NP_001424390.1"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
                     /translation="MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFD
                     CCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQMKAYEKQRGARREEQKEL
                     QRAAAQDQVRGFLEKESAIVSRPLNPFMPKAATLPNTDGEQPGPSVGPLGKDKDKALP
                     SFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRS
                     ERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVL
                     QRGGTGFAGSGVKLQAEMSRPVMQA"
     misc_feature    306..530
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    306..530
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    954..1157
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     misc_feature    954..1157
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     exon            367..472
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            473..554
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            555..714
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            715..833
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1021
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1130
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1235
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagttga agcaacgaca ggacggatag tcgtttttga gagataacat ttctcagctg
       61 gaggtggcta gctcagctgg cccttgcttg gtggcagtca caggaagccc tgcggtgaag
      121 gtgtgaagaa aaactgtaac tgcagttcca gggcatctgg gctctcctct ggcctctgca
      181 ggcaccagac acatgcgagt tcaaaaggct tctggagcag gctactgacc acaagcccag
      241 gaggtgttcg tgtcctgtgt gagtgaggtc accctgccac ttcccccttg gacaagatga
      301 caaggcatgg caagaactgc actgcagggg ctgtctacac ctaccacgaa aagaagaagg
      361 acacagcggc ctcaggctat gggacccaga acattcgact gagccgggat gctgtgaagg
      421 actttgactg ctgctgtctc tctctgcagc cctgccatga ccctgtggtc accccagacg
      481 gctacctgta tgaaagggag gcaatcctgg agtacatcct acaccagaag agagagattg
      541 cccggcagat gaaggcctat gagaagcagc gaggagcccg gagagaagag cagaaagagc
      601 tgcagcgagc tgcagcacag gaccaagttc gaggcttcct ggagaaggag tcagccattg
      661 tgagccggcc cctcaacccc ttcatgccca aggctgccac cttgcccaac acagatggtg
      721 aacagccagg gcccagtgtg ggtcccctag gcaaggacaa ggacaaagca ctacccagct
      781 tctggattcc ctcactaacg cccgaggcaa aggccaccaa gctggaaaag ccgtcccgca
      841 cggtgacctg cccgatgtct gggaagccac tgcgcatgtc ggacctgacg tcagtgcgct
      901 tcacacagct ggacgactct gtggaccgag tggggctcat cacgcgcagt gagcgctacg
      961 tgtgcgcagt gacccgagac agcctgagca acgccacgcc gtgtgcggtg ctgcggccct
     1021 ccggggctgt ggtcaccctg gagtgtgtgg agaaactgat ccggaaggac atggtggacc
     1081 ccgtgaacgg agatacgctg acggagcggg acatcatcgt gctgcagcgg ggtggcacag
     1141 gctttgcagg ctccggagtg aagctacagg cagaaatgtc ccggccagtg atgcaggcct
     1201 gagccgtgac ctaataaact tggacgtgaa caggc
//
LOCUS       NM_001437495            6890 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 4, mRNA.
ACCESSION   NM_001437495 XM_063284364
VERSION     NM_001437495.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6890)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6890)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6890)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6890)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6890)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6890)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6890)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6890)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6890)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6890)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284364.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.2129.1,
                                           SRR26643298.3339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-4066           JAXUCZ010000001.1  128277918-128278787 c
            4067-4164           JAXUCZ010000001.1  128277712-128277809 c
            4165-4392           JAXUCZ010000001.1  128276273-128276500 c
            4393-4559           JAXUCZ010000001.1  128271583-128271749 c
            4560-5034           JAXUCZ010000001.1  128266965-128267439 c
            5035-5252           JAXUCZ010000001.1  128265159-128265376 c
            5253-5396           JAXUCZ010000001.1  128263777-128263920 c
            5397-6890           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..6890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6890
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5491
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 4 is encoded by transcript variant 4; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 4"
                     /protein_id="NP_001424424.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASR
                     DLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHP
                     RDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHN
                     RYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLI
                     PSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDV
                     NDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRS
                     NHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSK
                     GKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNS
                     VSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKT
                     ITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKA
                     HSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVAT
                     ARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETL
                     LSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGD
                     PNYLVGANCVSVLIDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    5090..5386
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     misc_feature    5090..5386
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..4066
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4164
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4392
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..5034
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5252
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5396
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..6890
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3241 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3301 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3361 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3421 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3481 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3541 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3601 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3661 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3721 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     3781 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     3841 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     3901 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     3961 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4021 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4081 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4141 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4201 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4261 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4321 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4381 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4441 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4501 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4561 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4621 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4681 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4741 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     4801 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     4861 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     4921 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     4981 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5041 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5101 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5161 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5221 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5281 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtgc
     5341 gtccatgact cctgacggtt ggtcttttgc tctaaaatca tccgactcct cgtcgggtga
     5401 ccctaaaact tggcaaaaca agtgtcttcc tggagatccg aattaccttg ttggagccaa
     5461 ctgtgtttct gtcctgattg accactttta attcttagag tctagcagct ggactaagca
     5521 gtgtgaacat ggattgaact tactgaatgg aaccactcta atgagtattc tattttctta
     5581 gaatttatac tgcagttagt agtattaaac atttgttgga actgataaag gttagtgagc
     5641 atgcccctga accacgatca gaaaacatgc tacaagctgt gtgttattga gtggagaact
     5701 gtcaggcatt ggctagaggt tcaaagatat tttgctttgt aatgattttt gtactttttt
     5761 atggtcactg cttaacttca catactgatt tccgttaaaa ataccagcca gtaaatgggg
     5821 gtgcatttga gttttgttct ttccaaagta cactcaacct ttactatggc cttggcctag
     5881 catacacatt tattttatta tgcatgaggt aatgtgcaca cattttttac aaatgcacct
     5941 ggaatatata accagtgtag tggatttaac agaaatgtac agcaggggga tttataactt
     6001 ggggagggag gggcaaatga agacaattcc ttattgtata tgaaaacaca tttctcttag
     6061 ggaaggacac caaagcatgt gagcccagtt ccatggccgc tgaatctata aattaacata
     6121 tcaccacaga catccaacca gcaggaatgc cttaccctca tggttttcat tcttagatca
     6181 tttcgctctg tagtactaag tttttatgag tttgtgcgta cctagatact gtatcatgga
     6241 aaagactgag gaaattgtgg acttgatggt ttcggaaatg tgtaaatcac ctggaagaaa
     6301 gtaatggtgt gacttaaaat attttttttt gacaagggag agtggttggt ggtcttctgt
     6361 tctttgggct atgcatctga gatgtttgat gtgttcagga cgcatgtaca taatgcgtgc
     6421 ataccacttt tgttcttggt ttgtaaatta acttttataa actttacctt tttatacata
     6481 aacagaaccg agtttctaag gctacctttg tattctctcc tgtacctctt gagccttgaa
     6541 ctttgacctc tgcagcaata aagcagcatt tctacacata taaggtcatt tttttaagaa
     6601 aaagaatgca cagagttgtt acatttttaa gtgctgcatt taaaagatac agttactcta
     6661 gtttgattaa attcttgcaa agtatccctt ctgtaaaatt tgtgatacaa tgctgtgccc
     6721 taaagtgtat ttttttacta atagtttatt atggcacatc agcacgattt ctgtttagat
     6781 aatacaccac tacattctgt taataatcat taggtgtgaa aggatttctt ttgtggttat
     6841 taaaaatctc aaatttctaa atctgcaaga ataaaacttt ttaaaataca
//
LOCUS       NM_001437455            1793 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 13, mRNA.
ACCESSION   NM_001437455 XM_063284148
VERSION     NM_001437455.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284148.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2980.1,
                                           SRR26360181.140237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-653             JAXUCZ010000001.1  104572222-104572332
            654-940             JAXUCZ010000001.1  104572931-104573217
            941-1135            JAXUCZ010000001.1  104574234-104574428
            1136-1309           JAXUCZ010000001.1  104574810-104574983
            1310-1445           JAXUCZ010000001.1  104576616-104576751
            1446-1613           JAXUCZ010000001.1  104577665-104577832
            1614-1793           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1793
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1691
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 13 is encoded by transcript variant 13;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     13"
                     /protein_id="NP_001424384.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KGPRPDVLTQENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEA
                     ELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGP
                     SLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWER
                     AQREQAQSARGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQ
                     NSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPA
                     CPSCQRLHKKILPSPVSPAAPTLLSPGAGAPGLGQTRQGRGPELHPSAGPRRSRSGQE
                     PTADGQDEAGGEGGHFGLYAFEDVFPPRPTQPPAT"
     misc_feature    135..>1445
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..>1445
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>743
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>743
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..653
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..940
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1135
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1309
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1445
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1613
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1793
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 agggcccccg ccctgatgtt ctgacccagg agaactgccg caaggtgacc cgttcagtgg
      601 aagacgctga aatcaaaacc aatgtcctga agcagaactc tgccttgttg gaggagaagc
      661 taagatacct ccagcagcaa ctgcaggatg agacgccccg gagacaggag gccgagttgc
      721 aggagctgga gcaaaaacta gaggctggcc tctcccggca tggcctaggc cctactactc
      781 ccattcaggg ctgctccggt cctcctggta gcccggagga acccccgcgg ccgcgaggcc
      841 tgccctccaa tggctggggc atggcaatcc gcgcagggga gggaccctcg ctgagcgagc
      901 aggagttgca gaaggtctcc agcggcctag aggagctgag gagggaggtg tcctcgctgg
      961 cagctcggtg gcatcaggag gagggggcgg tgcaggaggc cctaaggttg ctgggaggcc
     1021 tgggcggccg tctggatggc tttctgggcc aatgggagcg ggcgcagcgg gaacaagcac
     1081 agtccgcacg gggtttgcag gagctgcgag gacgagcaga tgagctgtgc actatggtgg
     1141 agaggtcagc agtgtctgtc gcttcactga ggagcgaact ggaggcactg ggcccagtaa
     1201 aaccgattct ggaggagctg ggacggcaac ttcaaaactc ccgaagggga cctgaccatg
     1261 tcttgaactt ggatcgtcct gcccaaggtc cctgtcctcg atgtgccagc caggggcagc
     1321 agttatccac ggagtcccta cagcagctgc tggaacgtgc gctgacccca ctggtggacg
     1381 aagtgaagca gaagggtctg gctcctgcct gccccagttg ccagaggcta cacaagaaga
     1441 ttctgcccag tccagtaagc ccagcggcgc ctacactcct ctccccagga gctggagcgc
     1501 caggccttgg ccaaacacgt cagggcagag gccctgagct ccacccttcg gctggcccaa
     1561 gacgaagccg ttcgggccaa gaacctactg ctgacggaca agatgaagcc ggaggagaag
     1621 gtggccactt tggactatat gcatttgaag atgtgttccc tccacgacca actcagccac
     1681 ctgccacttg aggggtccac aggggcaatg gggggaggaa gcactggagg ggctccccct
     1741 aaacgtgggg gtccaggctc tgaacaataa atggcctctc atgctggcat gaa
//
LOCUS       NM_001014011            2629 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus GRAM domain containing 2B (Gramd2b), transcript
            variant 1, mRNA.
ACCESSION   NM_001014011 XM_225748
VERSION     NM_001014011.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001014011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090001.1, SRR26643287.35034.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000018.1  52082032-52082284
            254-373             JAXUCZ010000018.1  52149457-52149576
            374-485             JAXUCZ010000018.1  52153538-52153649
            486-552             JAXUCZ010000018.1  52155530-52155596
            553-656             JAXUCZ010000018.1  52157431-52157534
            657-752             JAXUCZ010000018.1  52160835-52160930
            753-824             JAXUCZ010000018.1  52163592-52163663
            825-905             JAXUCZ010000018.1  52163752-52163832
            906-1017            JAXUCZ010000018.1  52167125-52167236
            1018-1140           JAXUCZ010000018.1  52167894-52168016
            1141-1228           JAXUCZ010000018.1  52169053-52169140
            1229-1333           JAXUCZ010000018.1  52170384-52170488
            1334-1427           JAXUCZ010000018.1  52175620-52175713
            1428-2629           JAXUCZ010000018.1  52178855-52180056
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11-q12.1"
     gene            1..2629
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain containing 2B"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
     exon            1..253
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    99..101
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="upstream in-frame stop codon"
     CDS             132..1469
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="isoform 1 is encoded by transcript variant 1; GRAM
                     domain-containing protein 3; GRAM domain-containing
                     protein 2B; GRAM domain containing 3"
                     /codon_start=1
                     /product="GRAM domain-containing protein 2B isoform 1"
                     /protein_id="NP_001014033.1"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
                     /translation="MVKKPISSSDEVFKFEIPSSPKSSAGASHSSTDSPSSVFLSSEA
                     ENGVEDRKRFSKSPTAQSPTSSVEAESPDQKRSLGLWSKSSFDGSNLLSDKNDCKTES
                     KADSKTERKKSSSSSQYKANMHFHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSE
                     NWICFHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDS
                     TYKLLKSICGHLENTSVGNSPNPSSAENSFRADRPSSLRLDFNDEFSDLDGVVQQRRQ
                     DLEGYSSSGSQTPESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGKAKILP
                     AHGQSETIGILHKMESRKCPTLRHILIFYAIIVCALIISTFYMRYRINTLEERLGSLT
                     SIMDPHSTEQTAPSSLGSQVQLNVEVLCQELTANIVTLEKIQNNLQKLLENGD"
     misc_feature    132..488
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVG8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    132..134
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q96HH9; propagated from
                     UniProtKB/Swiss-Prot (Q5FVG8.1); acetylation site"
     misc_feature    534..812
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     misc_feature    534..812
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     misc_feature    843..845
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PEM6; propagated from
                     UniProtKB/Swiss-Prot (Q5FVG8.1); phosphorylation site"
     misc_feature    894..896
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PEM6; propagated from
                     UniProtKB/Swiss-Prot (Q5FVG8.1); phosphorylation site"
     misc_feature    924..926
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5FVG8.1); phosphorylation site"
     misc_feature    960..1124
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVG8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            254..373
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            374..485
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            486..552
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            553..656
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            657..752
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            753..824
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            825..905
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1017
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1140
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1228
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1333
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1427
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2629
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtcaggt aggaacttcc tgcatggcag gcactgtgac gagctgagac acaaccattt
       61 tcactttatt tgagaggtct agaaatgagt ttctgagctg acgtcttgaa gtggtggtgg
      121 ccgagatcag aatggtgaag aaaccgattt cctccagtga tgaggtgttc aagttcgaga
      181 ttcccagcag cccgaagagc agtgctgggg cctcacacag ttccactgac agcccaagct
      241 ccgtgtttct cagctcagag gctgagaatg gcgtggaaga cagaaagagg ttcagcaagt
      301 cgccaacagc ccaatctcct acctcatctg tggaggccga gtccccggac cagaagagaa
      361 gcctcggtct gtggtcaaaa tccagttttg atggctccaa tttgttgagc gataagaatg
      421 actgtaaaac cgaaagcaag gctgactcta agaccgaaag aaaaaagtct tcctcctcca
      481 gccagtacaa ggcaaacatg cactttcaca agctattcct tgatgtccca accgaggagc
      541 ccctgagaca aagctttacc tgtgctctcc agaaagaaat tctgtaccaa ggaaagctct
      601 ttgtgtcgga aaactggatt tgttttcatt ccaaggtctt tggaaaagac actaagatct
      661 ctatcccagc cttttcggta accttgatca agaaaaccaa aactgccctt ctggtgccaa
      721 atgccctgat catagcgacg gtcacagaca ggtacatatt cgtttccttg ctgtccagag
      781 actcaaccta caaactgcta aaatctattt gcggacactt agagaacaca agtgtcggga
      841 acagtcccaa cccatcttct gctgaaaata gcttccgggc agatcgccct tcctctctgc
      901 gtctggattt caatgatgaa ttctcagacc tggacggagt ggttcaacaa cgaaggcaag
      961 acttggaagg atacagcagt tccggctccc agactccaga atctgagaac tctcgagact
     1021 tccatgtgac cgaatctcag acagttctga atgtcacaaa gggagaaaca aaaccacctc
     1081 ggacagatgc ccacgggagc agagcgcctg atggaaaagc caagatcctg cctgcccatg
     1141 gtcaatcgga aactattggg attttacata aaatggagtc tcggaagtgt ccaactctcc
     1201 gtcatatcct tatattctac gccattattg tctgtgcgtt gatcatctcc accttctaca
     1261 tgagatacag gattaacact ctggaggagc gcctggggtc cttgacgtcc atcatggatc
     1321 cccacagtac tgagcagaca gccccctcca gcctaggatc acaagtacag ttaaatgtgg
     1381 aggtcctctg ccaagaactt acagctaaca tagtgacatt agaaaagata caaaacaact
     1441 tacagaagct gcttgagaat ggggactgag tgaccagctg ctggggccaa cataatacct
     1501 cacgttctcc cttgaagaag gtgcttctcg agagtctgtt gtgcgccccc tgctggccag
     1561 aggcgcaaga tgctgagaat ccagatgtgt ttgcgcttgg aggtctccag ctcaggaagg
     1621 ggggagggga atgagtttgc tttcgtgcaa taaaagttga ccttgtctct gctgctgcct
     1681 gaagataaca gacccatctc gggaggtgag caaggtcctg gaggacacct gtaacactcg
     1741 ggttatggta acatcagtaa acacagcact ccacgcttgt cagctctttc tcagccattg
     1801 ctgccttcac ccacaccaat cagccttcag acctaagggg aggtacactg tataccacca
     1861 aactcaaaat ggtcctttag agaattagtc acgagcctcc aacaaggtgg tgaatctctc
     1921 tcaatgagca ggcttgcttc tgacaccttc acgtttgtgg ttttgttttt gttttcgtgt
     1981 tcccttctac tcttatgttc tggtttcttt catctgtgcc tttaaatttt ccaattcggt
     2041 tgggtgagca tgtccggtaa agtgaattaa atgtcccatc tgtgttgtgc tgtcttgcgc
     2101 ctgtgactag tacgtaattg gagtgattct ccccaacctc ccgtcaggaa tctttgaggt
     2161 gtgacattga aatactaaat cagattcgct ctgaaaccaa aactaatctt tcagcccaaa
     2221 gctgtcctag aaatgtaata tgggaaggaa agccccgttc ctggggttgt aagtgcagtg
     2281 ggagctttga agcaggatgt ctgtgttgga ctctaaaacc catttcagca tggtaattgg
     2341 atgtctttct cctacaataa agcgtaagtg gtggtctgct aactttactt acagtatggg
     2401 ttggctggtt tttattaata atgatttagg gtaccataag atctgtaagt ataaaacatt
     2461 ctatctgcga tgcattttat aatcatttct atgaaatgta ttttgtttaa tcagagaagc
     2521 taataagcgg attggccgtg tcatgtgtat tggtctgcgt attgggtaac tgtgcctggt
     2581 gcacccccgg cttttaataa atactcattg cctaaggcac cctagttaa
//
LOCUS       NM_001437531            2830 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 6, mRNA.
ACCESSION   NM_001437531 XM_063277542
VERSION     NM_001437531.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277542.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1310525.1,
                                           SRR26643295.56154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000018.1  30382855-30382961
            108-277             JAXUCZ010000018.1  30385958-30386127
            278-439             JAXUCZ010000018.1  30386679-30386840
            440-982             JAXUCZ010000018.1  30394747-30395289
            983-1211            JAXUCZ010000018.1  30396391-30396619
            1212-1384           JAXUCZ010000018.1  30399772-30399944
            1385-1515           JAXUCZ010000018.1  30401686-30401816
            1516-2830           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2830
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..107
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            108..277
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            278..439
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    434..436
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            440..982
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..1573
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 6;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 2"
                     /protein_id="NP_001424460.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTAQASSNTELAL
                     GGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCFNSKLFLCSIC
                     FCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCSSVATPGQVKE
                     LVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTL
                     CRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWL
                     EKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKHFTDPDSPCFN
                     RLFHAVDVNGDIWEDEIED"
     misc_feature    785..961
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    785..961
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1046..1216
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1046..1216
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1313..1516
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1313..1516
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            983..1211
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1384
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1515
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2830
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggtgcc cggtgactgc aggcctggct ggctagcgtg ttgcgagggc cccagtcaag
       61 ggcatactgc ggaactttcg ggcccggctc agctaagcgg ccggaagatg gcagaatttc
      121 tgtagtatat tggatgcaaa tcccacatct tggtttctta tccagcttca gtctagcttc
      181 actggctaga aaataaatgg gatttgcaca aattccaagc cacagtgaaa taacgcttgc
      241 agcattgata tccttttctc ctcgttgtta ctaacagaaa attcaatgtc ggcagaagac
      301 ctggaagccc aggaggatga actactggcc ctggcaagta tttatgatgg agatgagttt
      361 agaaaagcag agtctgtcca aggaggggaa accaggatct atttggatct gccacagaat
      421 ttcaagatat tcgtgagcgc tctctgctct ctgcaagcac ctggacaacc tgtgggaaga
      481 acaccgaggc cgtgtggtgc tgtttgcctg gatgcagttt cttaaggagg agacccttac
      541 ctacctgaat attgtctctc cttttgagct caagatgggg tctcagaaaa aggttcagag
      601 aaggacaaca gctcaggcct cttccaacac agagcttgct ttgggaggag ctgctgctgc
      661 tgctgctgcg tcagatgtag accaagaaga cagtgtggat gagagagctg tacaggatgt
      721 agaatcattg tcaagtctga tccaggaaat cttggacttc aatcaagatc gacagatgaa
      781 gtgcttcaat agtaaactgt tcttgtgcag tatctgtttc tgtgagaagc tggggagtga
      841 ttgtatgtac ttcttggagt gcagacatgt atattgcaaa gcctgtctga aggattactt
      901 tgaaatccag atcaaagatg gtcaagttaa atgcctcaac tgtccagaac cacagtgttc
      961 ttcggtggct actcctggtc aggtcaaaga gctggtagaa gcagacttat ttgctcgcta
     1021 tgaccgcctc ctcctccagt ctactttgga tctaatggca gatgtggtgt attgtccccg
     1081 tccatgctgc cagctccctg tgatgcaaga gcctggtggc accatggcta tctgctccag
     1141 ctgcaatttt gccttctgca ccttatgcag actgacctat cacggggttt ctccatgtaa
     1201 ggtaacggca gagaaattaa tagacttacg gaatgaatac ctacaagcag atgaagctac
     1261 taaaaggttc ttggaacaga ggtatggcaa gagggtgatt cagaaggccc tggaggagat
     1321 ggagagtaaa gactggctgg agaagaactc caagagctgc ccctgctgtg gaacgcccat
     1381 acagaaatta gacggctgca acaagatgac ctgtactggc tgtatgcagt atttctgctg
     1441 ggtttgcatg ggctctctct caagagcaaa cccttacaaa catttcactg atcctgattc
     1501 tccatgcttt aacaggttgt tccatgccgt ggatgtcaat ggagacattt gggaagatga
     1561 gattgaggac tagttcattc ctgctcgcaa tgtagaaatg gaatggtttg ccctgacctt
     1621 ctgtcaagta cacaaagagc cctcgcagga tatttagggt accatctatt cactcttcag
     1681 tgtagaagga agaacagggt ttatattttc ctttggttct actgattaag gcacgtacat
     1741 ttccatgtaa cataatctga taaaattata tgccaaagga tcagaaatga aaactataga
     1801 ttaaatatta taatatgccc aaactgtgaa tagttaaaaa gtaaatattt attttctccc
     1861 ccaagcttta ggttagggag agggtcaaga gttaagcttt tagaccatgt ccaagaagcc
     1921 cctgcagctg gggacagtca cagccccagc cacactgtcc tgggagcctg atccattctc
     1981 tgtacactgc tcatttccat tcgtgctttg gagagagcct ctgctctgta actgaccaaa
     2041 tgtccagtgt tgttctgttg tactgcttgc cagaatagaa atctataata aattaaaaaa
     2101 tatttttagt attataatcc ctgtgggtca cttgatattt atgaatagtg tattgaatcc
     2161 cctggtttag agccaaatgt agaatttagg attctggctc agaattcctc tagattcaga
     2221 gtcagagctg tctgtgctcc cttttgttct cagctttctc cctttgcctc ccaccttctg
     2281 ttggcaagta cagttttaat gttgattaca gcagtgtgtg tctttatttc ctctgctaga
     2341 atagaaaaga gcccaatata ttcctcatga atgctctctg aacctgtgaa cagcatcatg
     2401 gttctacccc accttctgaa cactcgggaa ttgggcttcc tcccctcccc tcccctcgta
     2461 gacagcagtg tttggagtga taatagtagc ttgatagcta gattcctaac cctggctttt
     2521 attggctttt tgaaaaactg tcttcctcct gattccctaa gtggcttggt gtagtcactt
     2581 ggtggatgtt ttggaaagga cagtaactca cctgtagctt gtgaacttgt gttttctact
     2641 gtgacattga aaattaagga ttgcttaact gtcagctcaa actgttgctg gattgtcaat
     2701 gaggatgctt aatcttaaca ataaagtaat ttaaaatcat cccgtaattg gagtaggcat
     2761 ggtgtctgtt gcttctgtca ccaaagcact gactgaatta aaactgactg tgtttctgtt
     2821 tgttctgtta
//
LOCUS       NM_001437437            5425 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus trafficking protein particle complex subunit 8
            (Trappc8), transcript variant 2, mRNA.
ACCESSION   NM_001437437 XM_006254461
VERSION     NM_001437437.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5425)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254461.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49478.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               JAXUCZ010000018.1  12454866-12455365   c
            501-695             JAXUCZ010000018.1  12442598-12442792   c
            696-785             JAXUCZ010000018.1  12433518-12433607   c
            786-960             JAXUCZ010000018.1  12432885-12433059   c
            961-1114            JAXUCZ010000018.1  12430131-12430284   c
            1115-1151           JAXUCZ010000018.1  12428051-12428087   c
            1152-1411           JAXUCZ010000018.1  12425874-12426133   c
            1412-1527           JAXUCZ010000018.1  12424974-12425089   c
            1528-1678           JAXUCZ010000018.1  12423362-12423512   c
            1679-1779           JAXUCZ010000018.1  12421992-12422092   c
            1780-1885           JAXUCZ010000018.1  12419690-12419795   c
            1886-2017           JAXUCZ010000018.1  12414949-12415080   c
            2018-2242           JAXUCZ010000018.1  12411582-12411806   c
            2243-2351           JAXUCZ010000018.1  12409700-12409808   c
            2352-2546           JAXUCZ010000018.1  12406067-12406261   c
            2547-2671           JAXUCZ010000018.1  12405437-12405561   c
            2672-2746           JAXUCZ010000018.1  12404566-12404640   c
            2747-2873           JAXUCZ010000018.1  12403111-12403237   c
            2874-3028           JAXUCZ010000018.1  12400790-12400944   c
            3029-3471           JAXUCZ010000018.1  12396148-12396590   c
            3472-3619           JAXUCZ010000018.1  12394455-12394602   c
            3620-3716           JAXUCZ010000018.1  12393566-12393662   c
            3717-3785           JAXUCZ010000018.1  12391995-12392063   c
            3786-3844           JAXUCZ010000018.1  12391823-12391881   c
            3845-4018           JAXUCZ010000018.1  12388345-12388518   c
            4019-4120           JAXUCZ010000018.1  12385151-12385252   c
            4121-4266           JAXUCZ010000018.1  12382387-12382532   c
            4267-4356           JAXUCZ010000018.1  12380763-12380852   c
            4357-5425           JAXUCZ010000018.1  12378825-12379893   c
FEATURES             Location/Qualifiers
     source          1..5425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5425
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="trafficking protein particle complex subunit 8"
                     /db_xref="GeneID:291750"
                     /db_xref="RGD:1309102"
     exon            1..500
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    110..112
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="upstream in-frame stop codon"
     CDS             344..4591
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="isoform 2 is encoded by transcript variant 2;
                     trafficking protein particle complex subunit 8-like;
                     trafficking protein particle complex 8"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 8
                     isoform 2"
                     /protein_id="NP_001424366.1"
                     /db_xref="GeneID:291750"
                     /db_xref="RGD:1309102"
                     /translation="MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLK
                     PFSRLTSEVHMRDPNNQLHIIKNLKIAVSNIVTQPPQPGAIGKLLNDVVSGSQPAEGL
                     VANVITAGDYDLNISATTPWFESYRETFLQSMPASDHEFLNHYLACMLVASSAEAEPM
                     EQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVTSGDEQRAESIYEEMKQKY
                     GTQGCYLLKINSRAPNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTMTSIDGLPDN
                     CRVHPLQIDQCGDTPHNTDGSDHAKSASSVHETKKASTGLIRGACLTLTDHDRIRQFI
                     QEFTFRGLLPHVEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSISELKSTS
                     GLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAV
                     SAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAERCVLLSAEILKSQSKYAEAAALL
                     IRLTSEDSDLRSALLLEQAAHCFINMKNPMVRKYAFHMILAGHRFSKAGQKKHALRCY
                     CQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAF
                     LREYLYVYKNVNQLSPDGPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQ
                     EYDAESSQQWRELEEHVVAVANKGVIPSSFYPTQYCLNSYSDNSRFPLAVVEEPITVE
                     VAFRNPLKVPLLLSDLSLLWKFQPKDTSGKDTEKERVTGEPEMIGTEVISEFLINSEE
                     SKVARLKLFPHHIGELHILGVVYNLGTIQGSVTVDGIGALPGCHTGKHSLGMSVRGRQ
                     DLEIQGPRLNNTKEEKTSVKYGPDRRLDPIVTEEMPLLEVFFIHFPTGLLCGEIRKAY
                     VEFVNVSQCPLTALKVVSKRPEFFTFGGNTAALTPLSPSTSENCSAYKTVVTASPSLG
                     TAFVSTASSVDFGTGTGQQLEAIPVPLPDSVLLPGASVQLPMWLRGPDEEGVHEINFL
                     FYYESVKKQPKKRHRILRHTAVICTSRSLNVRATVCRSNSLEDEEGRGGNMLVFVDVE
                     NTNTSEAGVKEFHMVQVSSSSKHWQLHRSVNISENRDAKLASREKGKFCFKAVRCKQK
                     EGDKQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELRRTQDQLPAYPEKNASE
                     GAVRLIEKCSEVDLSIVVLWKAYVVEDNKQLILEGQHHVVVRTVGKEACSHSQKQEPP
                     EMELLKFFRPENTTVSARPSVEQLSNLIKTSLHYPESFHHPFHQKSLCLVPVTLLLSN
                     CSKAEVDVIVDLRHKTTSPEALETHGSFTWLGQTQYKLQLKSQETHSLQLKACFVHTG
                     VYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIINNA"
     misc_feature    821..2101
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="ER-Golgi trafficking TRAPP I complex 85 kDa
                     subunit; Region: TRAPPC-Trs85; pfam12739"
                     /db_xref="CDD:463688"
     misc_feature    821..2101
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="ER-Golgi trafficking TRAPP I complex 85 kDa
                     subunit; Region: TRAPPC-Trs85; pfam12739"
                     /db_xref="CDD:463688"
     exon            501..695
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            696..785
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            786..960
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1114
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1151
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1411
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1527
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1678
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1779
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1885
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2017
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2242
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2351
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2546
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2671
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2746
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2873
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3028
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3471
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3619
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3716
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3785
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3844
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4018
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4120
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4266
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4356
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..5425
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcacgt gaggcgtgct cgcagggcct gccgggaata gtactgccgg cgggtcaggg
       61 ttcggcccaa catggcggtt cctgtcggac agtgaccaag gctttgccgt agggaggact
      121 gaacggcggt ggtcggcgtc cccacctgcc agggtgggat gcaaagcctc ggagagcgct
      181 gagcggaggc agggacgggc tcaggccctc agtcgaagca gcggcggcta ctcgcagtcg
      241 gctgcaggct ccggagtggg gccgcgcccg gccgggcagg cggcggcggc tgcggcaagc
      301 tcggctccga agcggggcgg aggccgggcg cccggccgcg atcatggccc agtgcgtgca
      361 gtcggtgcag gagctcatcc ccgactcctt cgttccctgc gtcgccgcgc tgtgcagtga
      421 cgaagccgag cggctcactc gcctcaacca cctcagcttt gccgagctgc tcaagccctt
      481 ctctcgcctc acttccgaag ttcacatgag agatcctaat aatcaactgc atataattaa
      541 aaatttgaag atagcagtaa gcaacattgt cacccagcca cctcagccgg gagccattgg
      601 gaagcttttg aatgatgttg tttctggcag ccagcctgca gaaggattag tcgctaatgt
      661 gattacagca ggagattatg accttaatat cagtgctact actccatggt ttgagtctta
      721 cagagagacc tttctgcagt ccatgccagc atcagatcat gagtttctga atcactattt
      781 agcatgtatg ctggtggcat catctgctga agcagaaccc atggaacagt tttcaaagtt
      841 gtcacaggaa cagcatcgaa ttcagcacaa cagtgattat tcctacccta agtggtttat
      901 cccaaataca cttaaatatt acgtgctttt gcatgatgtg acttcaggag atgaacagag
      961 agctgaatca atttatgaag aaatgaaaca gaaatatgga actcagggtt gctatttact
     1021 taaaattaat tctcgagcac caaatcgagc atcagatgag cagataccag atccttggag
     1081 tcagtatctc cagaaaaata gtattcaaaa ccaggaatca tatgaagatg gcccttgtac
     1141 tatgacctcc atagatggcc ttccagataa ctgcagagtt catccacttc aaatagacca
     1201 gtgcggtgac actcctcata acaccgatgg ctcggatcat gcaaagtctg cttcttcagt
     1261 acatgagaca aagaaagcaa gcactggact gattcgtggt gcctgtttaa cacttactga
     1321 tcatgataga attcgacagt ttatacaaga atttacattc cgtggccttt tgccacacgt
     1381 agagaaaaca attcgtcagt taaatgatca gctaatatca aggaaaggtt tgagtcgatc
     1441 tctgttttct gccactaaga agtggttcag tggcagtaaa gttccagaaa agagcatcag
     1501 tgagctgaag agcacgtcgg ggttgttgta tccaccagaa gcacctgagc ttcagatcag
     1561 gaagatggcg gacttgtgct ttttggtgca acactatgat ttggcctaca gttgctatca
     1621 cactgcaaag aaggactttc ttaatgatca agccatgctt tatgcagcag gtgccttgga
     1681 aatggcagca gtgtcagcct ttcttcagcc tggagctccc aggccgtacc ctgctcatta
     1741 catggacaca gcaattcaga catataggga tatctgcaag aatatggtgc tggctgaaag
     1801 atgtgtgttg cttagtgccg aaattttaaa aagtcaaagc aagtacgcag aggctgcagc
     1861 tcttctaata cggttgacaa gcgaggattc tgatctccga agtgcacttc ttttggaaca
     1921 ggctgcacat tgtttcataa acatgaagaa ccccatggtt agaaaatacg catttcacat
     1981 gatcctggca ggccaccgtt ttagtaaagc agggcagaaa aagcacgctt tgcgctgcta
     2041 ttgtcaagcc atgcaagttt acaaaggaaa aggctggtct ctggcagagg atcatatcaa
     2101 cttcaccatc gggcgccagt cctatactct gaggcagctg gacaacgctg tttccgcttt
     2161 cagacatatt ttaatcaatg aaagcaagca gtctgccgct cagcagggag ccttcctcag
     2221 agaatatctc tatgtttata agaatgtaaa tcagctgtca ccagatggcc ctttaccaca
     2281 gcttccctta ccatacatta acagttcagc aacacgggtt ttctttggcc atgacagacg
     2341 accagcagat ggtgaaaagc aagcggctac tcatgtgagt cttgatcaag agtatgacgc
     2401 tgagtcgtcc cagcagtggc gagaacttga ggagcatgtt gtggctgtgg ctaataaagg
     2461 agtaatccca tccagtttct atcctacaca gtattgcttg aacagttact ccgataactc
     2521 cagatttcca ctggcagttg tagaagagcc aattactgtg gaagtggctt ttagaaaccc
     2581 tttaaaagtt ccgcttttgc tgtctgattt gtcattgctc tggaagtttc agcctaaaga
     2641 caccagtggg aaagacactg aaaaagaacg agttacaggt gaacctgaaa tgattggaac
     2701 tgaagttatt tcagaatttt taattaacag tgaagaatct aaagtggcaa gactgaagct
     2761 ctttccccat cacatagggg agctgcacat cctgggagtt gtgtataatc ttggcactat
     2821 tcagggctcc gtgacagtag atggcattgg tgctcttcct ggatgtcaca caggaaaaca
     2881 ttctctgggt atgtccgtcc gagggagaca ggatttagaa attcaaggcc ctcgacttaa
     2941 caacaccaag gaggagaaga cgtctgttaa gtatggccct gaccgacgtt tggaccccat
     3001 agtcacggaa gagatgccgc tcctggaggt gttctttata cattttccta caggtctcct
     3061 ctgtggagaa atccgaaaag catatgtaga gtttgtcaat gtcagccagt gtcctctgac
     3121 tgcattgaaa gtggtatcta aacgtcccga gttcttcact tttggtggca atactgctgc
     3181 tctaacaccg ctgagcccct ccacatctga gaactgcagt gcctataaga cggttgtgac
     3241 agcgtccccc tccttgggga cagcatttgt gtcaacagca tcatctgtgg acttcggaac
     3301 tggcacagga cagcagctgg aggccattcc tgtccccctt cctgactctg tgctactccc
     3361 tggagcttct gtccagctgc caatgtggct tcgtgggcca gacgaagaag gtgtccatga
     3421 aattaacttt ttattttact atgaaagtgt taaaaagcag cccaaaaaac gacacagaat
     3481 attaagacac actgcagtta tttgcactag ccggtctttg aacgtgcgag cgactgtttg
     3541 tagaagtaat tcccttgaag acgaagaagg caggggcggc aatatgctag tcttcgtgga
     3601 tgtagaaaat accaatacta gtgaagcggg agttaaggag ttccacatgg tgcaggtgtc
     3661 aagtagcagc aagcactggc agctacacag atccgtgaac atctccgaaa acagagatgc
     3721 caaacttgcc agtagagaga agggaaagtt ttgcttcaag gcagtaagat gtaaacaaaa
     3781 ggaaggtgat aaacagtcct cagaaaaata cacttttgca gatatcatct ttggaaatga
     3841 acagataata agttcagcaa gtccatgtgc agatttcttt taccgaagtt tatcctcaga
     3901 gttgagaaga acacaagacc agcttcccgc ctatcccgag aaaaatgcct cagagggtgc
     3961 tgtcaggctg attgagaagt gcagtgaggt ggacctgagc attgtcgtcc tgtggaaggc
     4021 atacgttgtg gaagataaca agcagcttat tttagaaggc cagcatcatg ttgtcgttcg
     4081 cactgttggc aaagaagcct gttcacactc tcagaaacag gagccaccag aaatggaact
     4141 attaaagttt tttaggccag aaaacactac agtttctgca agaccatcag tagagcagct
     4201 ttctaatctc attaaaacaa gtctccacta cccggagtca tttcatcatc catttcatca
     4261 gaaaagcctt tgcttagtgc cagtcaccct tttactttct aactgttcta aggctgaggt
     4321 agatgtaata gttgatctcc ggcataaaac aacaagtcca gaggcattgg aaactcacgg
     4381 atcattcaca tggcttggac agacacagta taaactccag ctgaaaagcc aagagacgca
     4441 cagtttgcag ctgaaggcat gctttgttca tacaggcgtt tataaccttg gaactccaag
     4501 ggtattcgcc aagttatcgg accaggtgac agtatttgaa acaagtcagc agaactccat
     4561 gcctgctttg attatcatca ataacgcgtg acagccgaga gtcacagact cagtctgact
     4621 ttgtggagtt ggttttacaa cagcgtttga aatacccaac ttgttcagga agttctctga
     4681 tcactgcaaa acacaggggc ttggcactta gctgacacag tatgctgggc tgagaatgct
     4741 tagactcccc cttttttttt ccccttttaa acctggtaat aatttacatg cttataatac
     4801 agaattcaat gtatccatac accttaagcc ttaagtctta aaaaaacgtc caagtctgtt
     4861 gcaacttaac ggatggttgt gactcttagg agtggttttg aggaatgaaa ggccttgctg
     4921 gtaatactcc tgttaagcca tttaccactt acctttactg tgaaattcta gagagtgtta
     4981 aatacagatt gtcctgcctt gccccagaca gtcctgtgag atgggttttg aacttcggtt
     5041 gtggacactc atacttcagt gtggtgtcct ctggcttata cataactgta aaaaagcttt
     5101 tctgatgctt tgaacatagt tttggaagga gtttgacttt attcccttgc tcatctctta
     5161 ctgtcacact atttcacaat aagatttttg tcattaaatc atattcttta ttataactaa
     5221 caattaagtt gatctgttta aaatataaat ctactccagt taaaaataag cttttcaaaa
     5281 atgtattata tttataacaa atttactgta aatagaataa agacatacta ttcactgtat
     5341 aaatttatta gatgcctttt ttaaaacctg ctttgtgagg acttcatata ttctttattt
     5401 aaaataaagt cagacgtgta cagta
//
LOCUS       NM_001437450            1831 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 8, mRNA.
ACCESSION   NM_001437450 XM_006229020
VERSION     NM_001437450.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229020.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.195893.1,
                                           SRR26643293.2997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-702             JAXUCZ010000001.1  104572249-104572332
            703-989             JAXUCZ010000001.1  104572931-104573217
            990-1184            JAXUCZ010000001.1  104574234-104574428
            1185-1358           JAXUCZ010000001.1  104574810-104574983
            1359-1494           JAXUCZ010000001.1  104576616-104576751
            1495-1651           JAXUCZ010000001.1  104577708-104577864
            1652-1831           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1831
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1623
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 8 is encoded by transcript variant 8; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     8"
                     /protein_id="NP_001424379.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALL
                     EEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEP
                     PRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQE
                     ALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLR
                     SELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQ
                     LLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQD
                     EAVRAKNLLLTDKMKPE"
     misc_feature    187..1620
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1620
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    688..690
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    802..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    859..861
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    943..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..989
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1184
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1358
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1651
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1831
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaagga gaactgccgc aaggtgaccc gttcagtgga agacgctgaa
      661 atcaaaacca atgtcctgaa gcagaactct gccttgttgg aggagaagct aagatacctc
      721 cagcagcaac tgcaggatga gacgccccgg agacaggagg ccgagttgca ggagctggag
      781 caaaaactag aggctggcct ctcccggcat ggcctaggcc ctactactcc cattcagggc
      841 tgctccggtc ctcctggtag cccggaggaa cccccgcggc cgcgaggcct gccctccaat
      901 ggctggggca tggcaatccg cgcaggggag ggaccctcgc tgagcgagca ggagttgcag
      961 aaggtctcca gcggcctaga ggagctgagg agggaggtgt cctcgctggc agctcggtgg
     1021 catcaggagg agggggcggt gcaggaggcc ctaaggttgc tgggaggcct gggcggccgt
     1081 ctggatggct ttctgggcca atgggagcgg gcgcagcggg aacaagcaca gtccgcacgg
     1141 ggtttgcagg agctgcgagg acgagcagat gagctgtgca ctatggtgga gaggtcagca
     1201 gtgtctgtcg cttcactgag gagcgaactg gaggcactgg gcccagtaaa accgattctg
     1261 gaggagctgg gacggcaact tcaaaactcc cgaaggggac ctgaccatgt cttgaacttg
     1321 gatcgtcctg cccaaggtcc ctgtcctcga tgtgccagcc aggggcagca gttatccacg
     1381 gagtccctac agcagctgct ggaacgtgcg ctgaccccac tggtggacga agtgaagcag
     1441 aagggtctgg ctcctgcctg ccccagttgc cagaggctac acaagaagat tctggagctg
     1501 gagcgccagg ccttggccaa acacgtcagg gcagaggccc tgagctccac ccttcggctg
     1561 gcccaagacg aagccgttcg ggccaagaac ctactgctga cggacaagat gaagccggag
     1621 tgaggacgga ggcagagggc atgggaggag gggagaaggt ggccactttg gactatatgc
     1681 atttgaagat gtgttccctc cacgaccaac tcagccacct gccacttgag gggtccacag
     1741 gggcaatggg gggaggaagc actggagggg ctccccctaa acgtgggggt ccaggctctg
     1801 aacaataaat ggcctctcat gctggcatga a
//
LOCUS       NM_001437520            3013 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus dynamin 3 (Dnm3), transcript variant 3, mRNA.
ACCESSION   NM_001437520 XM_063272013
VERSION     NM_001437520.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Li,J., Zhang,D.S., Ye,J.C., Li,C.M., Qi,M., Liang,D.D., Xu,X.R.,
            Xu,L., Liu,Y., Zhang,H., Zhang,Y.Y., Deng,F.F., Feng,J., Shi,D.,
            Chen,J.J., Li,L., Chen,G., Sun,Y.F., Peng,L.Y. and Chen,Y.H.
  TITLE     Dynamin-2 mediates heart failure by modulating Ca2+ -dependent
            cardiomyocyte apoptosis
  JOURNAL   Int J Cardiol 168 (3), 2109-2119 (2013)
   PUBMED   23410488
  REMARK    GeneRIF: DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic
            death of cardiomyocyte.
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Grossman,G.H., Ebke,L.A., Beight,C.D., Jang,G.F., Crabb,J.W. and
            Hagstrom,S.A.
  TITLE     Protein partners of dynamin-1 in the retina
  JOURNAL   Vis Neurosci 30 (4), 129-139 (2013)
   PUBMED   23746204
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Tanifuji,S., Funakoshi-Tago,M., Ueda,F., Kasahara,T. and Mochida,S.
  TITLE     Dynamin isoforms decode action potential firing for synaptic
            vesicle recycling
  JOURNAL   J Biol Chem 288 (26), 19050-19059 (2013)
   PUBMED   23687302
  REMARK    GeneRIF: dynamin isoforms select appropriate vesicle reuse pathways
            associated with specific neuronal firing patterns
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Gray,N.W., Fourgeaud,L., Huang,B., Chen,J., Cao,H., Oswald,B.J.,
            Hemar,A. and McNiven,M.A.
  TITLE     Dynamin 3 is a component of the postsynapse, where it interacts
            with mGluR5 and Homer
  JOURNAL   Curr Biol 13 (6), 510-515 (2003)
   PUBMED   12646135
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Cook,T., Mesa,K. and Urrutia,R.
  TITLE     Three dynamin-encoding genes are differentially expressed in
            developing rat brain
  JOURNAL   J Neurochem 67 (3), 927-931 (1996)
   PUBMED   8752097
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Nakata,T., Takemura,R. and Hirokawa,N.
  TITLE     A novel member of the dynamin family of GTP-binding proteins is
            expressed specifically in the testis
  JOURNAL   J Cell Sci 105 (Pt 1), 1-5 (1993)
   PUBMED   8360266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063272013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.33659.1,
                                           SRR26360194.497191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000013.1  77371058-77371389   c
            333-406             JAXUCZ010000013.1  77297301-77297374   c
            407-556             JAXUCZ010000013.1  77240975-77241124   c
            557-760             JAXUCZ010000013.1  77239796-77239999   c
            761-859             JAXUCZ010000013.1  77215985-77216083   c
            860-1020            JAXUCZ010000013.1  77215253-77215413   c
            1021-1163           JAXUCZ010000013.1  77212750-77212892   c
            1164-1299           JAXUCZ010000013.1  77207732-77207867   c
            1300-1367           JAXUCZ010000013.1  77205597-77205664   c
            1368-1506           JAXUCZ010000013.1  77202373-77202511   c
            1507-1593           JAXUCZ010000013.1  77190691-77190777   c
            1594-1664           JAXUCZ010000013.1  77181775-77181845   c
            1665-1716           JAXUCZ010000013.1  77169168-77169219   c
            1717-1746           JAXUCZ010000013.1  77168277-77168306   c
            1747-1860           JAXUCZ010000013.1  77130509-77130622   c
            1861-1970           JAXUCZ010000013.1  77034331-77034440   c
            1971-2082           JAXUCZ010000013.1  76990952-76991063   c
            2083-2247           JAXUCZ010000013.1  76926535-76926699   c
            2248-2474           JAXUCZ010000013.1  76918517-76918743   c
            2475-2711           JAXUCZ010000013.1  76917749-76917985   c
            2712-3013           JAXUCZ010000013.1  76913116-76913417   c
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..3013
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="dynamin 3"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
     exon            1..332
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2748
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /EC_number="3.6.5.5"
                     /note="isoform 3 is encoded by transcript variant 3;
                     T-dynamin; dynamin, testicular; testicular dynamin"
                     /codon_start=1
                     /product="dynamin-3 isoform 3"
                     /protein_id="NP_001424449.1"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIE
                     AETDRVTGMNKGISSVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKE
                     KKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKA
                     SLLRAGVYPDKSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIP
                     KTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALA
                     IIGDINTVTVSTPAPPPVDDSWLQHSRRSPPPSPTTQRRLTLSAPLPRPASSRGPAPA
                     IPSPGPHSGAPPVPFRPGPLPPFPNSSDSYGAPPQVPSRPTRAPPSVPRFGAVKEEAV
                     EP"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    361..369
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    862..864
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    874..885
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1066..1068
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P39054; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    1747..2076
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    1747..2076
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    order(1747..1749,1753..1758,1762..1764,1813..1815,
                     2020..2025,2032..2034,2041..2046,2053..2055)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    order(1747..1749,1753..1758,1762..1764,1813..1815,
                     2020..2025,2032..2034,2041..2046,2053..2055)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    1978..1980
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    1981..1983
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50570; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    2134..2406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2134..2406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    <2428..2700
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    <2428..2700
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    2476..2478
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    2488..2490
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     exon            333..406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..556
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..760
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..859
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1020
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1163
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1299
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1367
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1506
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1593
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1664
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1716
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1746
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1860
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1970
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2082
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2247
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2474
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2711
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..3013
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagctgtc aggagcctag cagcgggtgg cagggatcgg acgacggtgc cgggactcag
       61 cggtgtgagc cccgcgcatc aacaaaccgg acaagtgctg cgaggcccgg gctgcctgcc
      121 aggtcgctga gtcgcgcagg gacctgtggg gcagttggcc gcacaggcaa gatggggaac
      181 cgggagatgg aagaactgat ccctctggtg aaccgtctgc aggacgcttt ctcggctctg
      241 ggacagagct gtctgctgga gctgccacag atcgccgtgg tgggcggcca gagcgccggc
      301 aagagctcag tgctcgagaa cttcgtgggc agggactttc ttcctcgagg ctcgggcatt
      361 gtgaccagac gacctcttgt actccagctt gtcacctcta aagcagaata tgccgagttt
      421 ctacattgca aaggaaaaaa atttacagat tttgatgaag ttcgccacga gatcgaagca
      481 gaaacggacc gagtaacagg aatgaataaa ggcatctcct ctgtacccat taaccttcga
      541 gtctactctc cccacgtgtt aaacctaacg ctaatcgacc tacctggaat aacgaaagtg
      601 cccgtgggag accagccgcc agatattgag tatcagatca gagatatgat tatgcagttc
      661 atcaccaggg agaactgtct gattttggct gtcacaccag ccaacaccga tcttgcgaac
      721 tcagatgccc tgaagctagc caaagaagtc gatcctcaag gcctgaggac cattggcgtt
      781 atcaccaagc tggatctcat ggatgaaggg acggatgcca gggatgtact agagaacaag
      841 ctgctacctc tccgcagggg ctatgtgggg gtggtcaacc gaagccagaa ggacatagat
      901 ggaaagaagg acattaaggc agctatgctg gcagaaagga aattttttct ctctcatcca
      961 gcatatagac acattgctga tcggatgggg accccacacc tccagaaggt cctgaatcag
     1021 caacttacca accatatccg agataccctg cccaacttca ggaacaagct acaggggcag
     1081 ctgctctcca tagaacatga agtagaagcc ttcaaaaact tcaaaccgga agaccccaca
     1141 aggaagacca aagcactgct acagatggtc caacagttcg ctgtggactt tgagaagaga
     1201 atcgaagggt cgggggatca agtagacacg ttagagctct ctggcggtgc taagatcaat
     1261 cgcattttcc acgaacgctt tccttttgag atagtgaaga tggagttcaa tgagaaagaa
     1321 ctgagaagag aaataagcta tgcaatcaaa aacatacacg ggatcaggac agggttgttt
     1381 actccagaca tggcgtttga ggcaatagtc aaaaaacaga tagtaaaact gaaagggcct
     1441 tctttgaaga gtgtggacct ggtgatgcag gaactgatca acacggtgaa gaagtgcacc
     1501 aagaggctgg ccaacttccc cagactttgt gaagaaacag aaaggattgt tgctaaccac
     1561 atccgtgagc gagaaggaaa gaccaaggac caggtcctgc tactgattga cattcaagtc
     1621 tcttacatta acaccaacca tgaggacttc atcggctttg caaatgctca gcagagaagc
     1681 agtcaggttc acaagaaaag cacaattgga aatcagggaa ccaatcttcc gccttcaagg
     1741 caaattgtga ttcggaaggg ctggctgacc gtcagcaaca ttggcatcat gaaaggaggc
     1801 tcgaagggct actggtttgt cctcacggca gaaagcttgt cctggtataa agacgatgag
     1861 gagaaagaaa agaagtatat gcttccactg gacaacctga aagtccggga cgtggagaaa
     1921 ggcttcatgt ccagcaagca cgtcttcgca ctcttcaaca cagaacaaag gaatgtctac
     1981 aaagactatc gttccctgga gctggcctgt gattcccagg aggatgtgga cagctggaag
     2041 gcgtctctgc tcagagctgg cgtctatcca gacaagtctt ttactgaaaa tgatgaaaat
     2101 ggacaagcag aaaacttctc catggacccg cagttggaga ggcaagtgga gactattcgc
     2161 aacctcgtag actcctacat gtcgataatc aacaaatgca tccgagacct aattccaaaa
     2221 acaataatgc accttatgat caataatgtt aaagacttca tcaactctga actcctagca
     2281 cagctctact cctctgagga ccagaacaca ctaatggaag aatccgtgga gcaggctcag
     2341 cgccgggatg agatgctccg gatgtaccaa gccctgaaag aagccctcgc gatcattggc
     2401 gacatcaaca cggtcactgt gtccacccca gccccacctc cagtagatga ctcctggctc
     2461 cagcattcca gaaggtcacc tcctccaagc cccaccaccc aaagaaggct gactctaagt
     2521 gctcccctcc cgaggcccgc atctagccgt ggaccagctc ctgccattcc ctctccaggc
     2581 ccccactctg gggctccccc agtcccattc cgtccaggcc cattacctcc ttttcccaac
     2641 agcagtgact cctacggagc ccctccacag gttccatcca ggcccacaag ggcacccccc
     2701 agtgttccaa ggtttggtgc tgtgaaggag gaagctgttg agccttgaag tcgctgggct
     2761 cagagttcat ggaaactgag cagcccgtgt gactagcctg ggtgtcactc cctgcggtca
     2821 cccacggaaa catcctgact taccctctcc tctcctgaca gccctctcaa actgtggtgt
     2881 ctttagcagc cgagtgtcac tgggacaaac ggtgaaatca ccttgtgatt tgtgatgtca
     2941 gctgctgcga gcactctgtt tctcctgact agccagccct ccttaaagaa aaaataaaaa
     3001 ccatactcag aca
//
LOCUS       NM_001437474            3524 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 4, mRNA.
ACCESSION   NM_001437474 XM_006254720
VERSION     NM_001437474.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3524)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3524)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3524)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3524)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3524)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3524)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3524)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3524)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254720.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.177602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000018.1  48404817-48404860
            45-147              JAXUCZ010000018.1  48472546-48472648
            148-220             JAXUCZ010000018.1  48485845-48485917
            221-1089            JAXUCZ010000018.1  48504584-48505452
            1090-1269           JAXUCZ010000018.1  48507187-48507366
            1270-1383           JAXUCZ010000018.1  48514668-48514781
            1384-1509           JAXUCZ010000018.1  48523111-48523236
            1510-1679           JAXUCZ010000018.1  48526537-48526706
            1680-1772           JAXUCZ010000018.1  48532075-48532167
            1773-2826           JAXUCZ010000018.1  48532658-48533711
            2827-2897           JAXUCZ010000018.1  48534878-48534948
            2898-3524           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3524
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..44
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..147
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             91..2982
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 1 is encoded by transcript variant 4;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 1"
                     /protein_id="NP_001424403.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAM
                     YSSCIHLPSNALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     misc_feature    <1051..1614
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1051..1614
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1132..1134,1138..1140,1150..1155,1162..1170,
                     1174..1179,1189..1191,1204..1206,1231..1233,1237..1239,
                     1243..1245,1360..1365,1372..1380,1384..1389,1399..1401,
                     1420..1422,1447..1449,1453..1455,1459..1461,1471..1476,
                     1483..1491,1495..1500,1510..1512,1519..1521,1546..1548)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1132..1134,1138..1140,1150..1155,1162..1170,
                     1174..1179,1189..1191,1204..1206,1231..1233,1237..1239,
                     1243..1245,1360..1365,1372..1380,1384..1389,1399..1401,
                     1420..1422,1447..1449,1453..1455,1459..1461,1471..1476,
                     1483..1491,1495..1500,1510..1512,1519..1521,1546..1548)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1132..1233
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1132..1233
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1237..1449
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1237..1449
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1453..1548
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1453..1548
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1621..1752
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1621..1752
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            148..220
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1089
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1269
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1383
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1509
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1679
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1772
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2826
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2897
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3524
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcctgcgg gaaagagcca aggcggcgga ggtgaacgcg cgaggatatt ataaatattc
       61 gaccttactc aaaatgtaca aagaagaata atggaagccc ctgaatatct tgatctggat
      121 gaaatcgact ttagtgatga catttcttat tcagtcacat ctctcaagac catcccagca
      181 ctgtgcagaa gatgtgactc acagaacgaa gacagaccag tttctagctc tagctggaat
      241 tgtggtgtct caactctcat tacaaacccg caaaagccca ctggaatcgc tgatgtatac
      301 agtaagttcc gcccggtgaa gcgagtttct ccactgaaac atcagccaga gactctggag
      361 agcaatgaaa gtgacgacca gaagaacaat acagtggaat accagaaagg gggggagact
      421 gaccagggcc cccagcctga ggagctcagc cctgaagatg gagtcggagg cttgccaggc
      481 aagggctcag agcccagcca ggcactgggt gagctggagc actatgacct cgacatggat
      541 gagattctgg atgtgcctta cattaaatcc agtcaacagc tggccccgct caccaaggtg
      601 acttcagaaa aaaggatttt gggtttatgc acaactgtca atggcctctc tgccaaaacc
      661 tgccctattg taagcgctga gacctccaca cccaacatgg ctccattgtg tgttctttct
      721 cctgtgaaaa gccctcactt acggaaagta cccagtgtcc tccgggacca gcacaagctc
      781 cctgcggaag aatcggagaa ctcacccgct cctggtaaat gcggccctgc atttgaatca
      841 gaaaaccaca gtaaggactt cttaaacaag gtctttagtg atccccatag tcggaaagct
      901 gagaagtctg ggccagactg caagctcagg cccttccgcc tgcagacctc ggcagcagga
      961 gccaaaccag aggagcaggt caacggcgtg agctgggcca gtgcccaagg cgcagaagaa
     1021 aggactgagt acctgcagaa agtaagaagc atactgaaca ttgtgaacga agggcagata
     1081 tcgctcttgc cacacctagc tgcagataat ctggacaaaa ttcacgacga gaacggaaac
     1141 aatctgttac acgttgctgc atcaaagggc catgcggaat gtctgcagca cctcacgtcg
     1201 ctgatgggcg aagactgtct gaatgaacgg aacgcagagc aactgactcc agcgggcctg
     1261 gccatcaaga atggtcagct ggagtgtgta cgctggatgg tgagtgagac ggaagccatt
     1321 gcggaactga gttgttccaa ggatttccca agcctaattc attacgcagg ctgctatggg
     1381 caggaaaaga ttcttctgtg gcttcttcag ttcatgcaag aacaaggcat ctcattggat
     1441 gaagtagatc aggaaggcaa cagtgctgtt catgtcgctt cacaacatgg ctaccttgga
     1501 tgcatacaga ccctggtgga gtatggagca aatgttacga tgcagaacca cgctggggaa
     1561 aagccctccc agagtgccga gcggcacggc cacaccctat gttcccggta cctcgtggtg
     1621 gtagagacct gtatgtcact ggcctcacaa gtggtaaagt tgaccaagca gctaaaggag
     1681 cagacagtgg agcgcgtcac actgcagagt caactccaac aacttctgga agcccagaaa
     1741 tcagagggca agtccctccc atcttcaccc agttcaccct cctcaccagc ttctagaaag
     1801 tcccagtgga aaattctaga tgcagatgac gagtctacag gcaaaagcaa actgggaacc
     1861 caggagggaa tacaagtcct tggaaactta tccagcaggg ctaggaccaa aggaaaagac
     1921 gaagactctg ataaaatcct acgtcagtta ttggggaaag aaatatcaga gaatgtctgc
     1981 acccaggaaa agctgtcatt ggaattccag gatgctcagg tatcctctag gaattcgaaa
     2041 aaaatacctc tagagaagag ggaactgaag ctagctagac tgcggcagct gatgcagaga
     2101 tctttgagtg aatctgacac ggattcaaac aactctgagg accccaaaaa tactcctgtg
     2161 aaaagagtgg acagacctag accacagccc attgtggaaa gtgtggagaa tatggacagt
     2221 gcagaaagct tacacctgat gataaagaaa cactctgtgg catcaggacg caggtttcct
     2281 tttggtatga aggcctccaa atccctggat gggcacagcc catctcccac ttcagagagc
     2341 agtgaaccag atttggactc ccattgcccg agcctgggaa tgactcctcc aacccaacct
     2401 tctacagaag ccactcagtg cagtcctgac agtgccactg cccagaaagt tgctacaagc
     2461 cccaagagtg ccctcaagtc tccatcatcc aagcgccgga catcccaaaa ctcaaaactg
     2521 agagtgacct ttgaggagcc tgttgtgcaa atggagcaaa ctagccttga actaaatgga
     2581 gaaaaagaca aagagagggg cagggccccc cagaggacta gtgagtcagg agaacaaatg
     2641 aaaaggcctt ttggaacctt ccgatccatc atggagagtt taagtggtaa tcagaacaac
     2701 aataataact accagccagc cagccagctg aagacctgca cactaccctt gacgtcactt
     2761 ggaaggaaga cagcagatgc caagggaaac cctgtgagcc ctgctagcaa aggaaagaat
     2821 aaggcagcga tgtacagcag ctgcattcat cttccctcta atgcgctggt cgaagagcat
     2881 ctgcgtgatt atgcacggct taatgacatc aaaagaaaca cgaagaaaac ttacaacgta
     2941 aagcacattg ctgaaccaga gccaaaggaa ctcttcttat aaattactct tagtatgagt
     3001 ctcacacatg ccctctggcc accattggga gttaatggac tgtggcaatc agaccatgag
     3061 aacaacacct caccagcgag cagaatatct ggatgcctta aatttataat atgagacttg
     3121 ttataagata cattttggac catatctgta catagaactt gtttgatttc ttttttaata
     3181 tgctgtttga aaacatgatc gggcaatgta tgcattgaca cattggacat ttgattgagt
     3241 cgaccttctt gaagcacatc caccagcacc tgacacgact agtgtttttg tgaattgcat
     3301 gaggatttgc tgatgttgat tagatgttca ccttctttgt aacaagggca gctgtggctc
     3361 agctcagtga ggccaggtca ctggttttat tttctgtcca gtgtgttttt ctgtcatttc
     3421 tactttttta ataaagaaaa ttaaacattt gtaacagcag actctgggcg tggggggcag
     3481 ggcatctact ttctaataaa tctgtgaagc tctgatttct aaaa
//
LOCUS       NM_001437433            2114 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Ras and Rab interactor-like (Rinl), transcript
            variant 2, mRNA.
ACCESSION   NM_001437433
VERSION     NM_001437433.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.1494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  93204794-93204825
            33-167              JAXUCZ010000001.1  93206397-93206531
            168-327             JAXUCZ010000001.1  93206696-93206855
            328-430             JAXUCZ010000001.1  93209713-93209815
            431-503             JAXUCZ010000001.1  93211848-93211920
            504-568             JAXUCZ010000001.1  93212006-93212070
            569-715             JAXUCZ010000001.1  93212633-93212779
            716-1192            JAXUCZ010000001.1  93212866-93213342
            1193-1480           JAXUCZ010000001.1  93213660-93213947
            1481-1612           JAXUCZ010000001.1  93214110-93214241
            1613-1776           JAXUCZ010000001.1  93214371-93214534
            1777-2114           JAXUCZ010000001.1  93214620-93214957
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2114
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     exon            1..32
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            33..167
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1821
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="isoform 1 is encoded by transcript variant 2; ras
                     and Rab interactor-like protein"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein isoform 1"
                     /protein_id="NP_001424362.1"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
                     /translation="MRLAQPDMVSAATTEEARLSWPLAEGADKSPLRVLSTTESLLRL
                     QRTQRVWQVPELDAEHAKAFLKPWPLGSFLVIGQDPDQVLMLKTGPSSGDINTYQIQK
                     FPGGVSLESSNLCMPDFPHLLAFLSASRDVLPRTLLLPTPTVGPGDKHSDPRRLGCIQ
                     VDTSGRVLSVVNQLYLETHGGWETETPQQTKPETGQKRSLAPRMPTPHRVSWVEESLK
                     PEAHHTGQEVHHPERQVHYPGPEAHSLGPEVHFPSPVLEEEEEVNNDSYKDEEEGCED
                     MLTAHIRALASARSSYVARQYQCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQD
                     YLAKDPDVRAVFGNRGPSIPREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELR
                     RLRRRQIALRVGAGPEGQSPALRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLA
                     GGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWF
                     GALYHIAHYQPDAGRAPQELSSEARASLRQWHRRRTLHQQAQPTAPENQPFEEPWAIG
                     DP"
     misc_feature    241..522
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    241..522
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    order(286..288,340..342,403..405,409..411)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(286..288,340..342,403..405,409..411)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(406..408,487..489)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    order(406..408,487..489)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    1363..1671
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     misc_feature    1363..1671
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     exon            168..327
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            328..430
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            431..503
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            504..568
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            569..715
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1192
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1480
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1612
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1776
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2114
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct gctcaggctc ccctcggaac agttcttgcc ctagctggag cagccttgag
       61 tcttgtcttc ctccatgcca gaggccaaag catggctcac tggtgcctgg cagcatgagg
      121 ctagcccagc cggacatggt gtctgcagcc actactgaag aggccaggct gagttggcca
      181 ctagcagaag gagcagacaa gagcccactg agggtcctca gcacgacaga gtcacttctt
      241 cgactgcaga ggacacagag ggtgtggcag gtccccgagc tggacgctga gcatgccaag
      301 gcctttctca agccgtggcc actggggagc ttcctggtca tcgggcagga ccctgaccag
      361 gtcctgatgt tgaagacagg accttcgtca ggagatatca acacctacca aattcagaag
      421 tttcctggag gtgtgtccct ggaatcctcc aacctctgca tgccagactt tcctcatctc
      481 ctggcctttc tgtcagccag cagggacgtt ttgccaagga ctctgctctt gcccacacct
      541 actgtggggc ctggagataa gcactcagat cctcgtcgac ttggctgcat ccaggtggac
      601 acctcaggga gggtgctgtc tgtggtgaac cagctctacc tggagaccca tggaggctgg
      661 gaaacagaaa caccgcagca aacaaagcca gaaactggcc agaaacgcag tctagccccc
      721 aggatgccca ctccacaccg ggtctcctgg gtggaagagt ctctgaaacc ggaagctcac
      781 catactggac aggaagtgca tcatccagaa agacaagtgc attatcctgg accagaagct
      841 cactctcttg ggccagaagt acactttcct agtcctgttc tagaagagga ggaagaagtg
      901 aacaatgaca gctacaagga tgaagaggaa ggctgcgagg atatgctcac tgcccacatc
      961 cgtgctctgg ccagtgcccg gagcagttat gtagccaggc agtaccaatg ccttcgagca
     1021 cgactcatct cagattctgg aaatccctac agcccagggg acccagccac agagctgctt
     1081 caggatgtac gccagctcct cactgacctc caggattacc tggcaaaaga ccccgatgtc
     1141 agagctgtct ttgggaatag gggacctagc atccctcggg aagaagatct tggccccgct
     1201 gtggaggtgg ccctgtgtcg agcggttctg gagcccctga agcccgccct gtggaccaaa
     1261 ctccgaactc tcagagccca ggaactgcgg cgactgcgcc ggcgccaaat agccttgagg
     1321 gtaggagcag gacccgaggg acagagcccg gccttgcgga accgtatcca cgcacgcctc
     1381 gctcacctgc acgcagcgtg cgccccgcgc cgcaaggtgg cgctgttgtt ggcggtgtgc
     1441 agcgatgtct atgcaggcct ggctggcggc gagaataaag agcccctggg ggctgacgcc
     1501 tttttacctg ccctgaccga ggagctgatc tggagtccac atattgggga aacacagctg
     1561 gatgtggagt ttcttatgga gctcttggat ccaggggagt tgcgaggaga agctgggtat
     1621 tatcttacca cgtggtttgg ggctctctac cacattgctc actaccagcc tgatgctggc
     1681 cgtgcacccc aggagctcag ctctgaggcc cgggcctcct tgcgccagtg gcaccgaaga
     1741 cggacactgc accagcaagc ccagcccaca gccccggaaa accagccctt tgaggagcca
     1801 tgggcaatag gggacccatg atgattggag tcctcaaaaa tcagtctcca gaaccttttg
     1861 gcccactcct ctgctaagca agattctgga ggcatctggg tcagcacagt gggtggggca
     1921 gaaaaaagga cgtggcgttt tgcactggct gttcctactt ccttccttcc cctcctggtc
     1981 tgtccacatg ttacctcaat gaggctctcc ccagcaaaca aaaccaacgc ctaaacaata
     2041 ctacaactac agccctctca cctgaatctc tctggggcag gtagaataaa ggcacagtcc
     2101 ccaaaaggta tcta
//
LOCUS       NM_001437540            1544 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus melan-A (Mlana), transcript variant 2, mRNA.
ACCESSION   NM_001437540
VERSION     NM_001437540.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Hoashi,T., Watabe,H., Muller,J., Yamaguchi,Y., Vieira,W.D. and
            Hearing,V.J.
  TITLE     MART-1 is required for the function of the melanosomal matrix
            protein PMEL17/GP100 and the maturation of melanosomes
  JOURNAL   J Biol Chem 280 (14), 14006-14016 (2005)
   PUBMED   15695812
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   De Maziere,A.M., Muehlethaler,K., van Donselaar,E., Salvi,S.,
            Davoust,J., Cerottini,J.C., Levy,F., Slot,J.W. and Rimoldi,D.
  TITLE     The melanocytic protein Melan-A/MART-1 has a subcellular
            localization distinct from typical melanosomal proteins
  JOURNAL   Traffic 3 (9), 678-693 (2002)
   PUBMED   12191019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO793296.1, FO793504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000001.1  236883220-236883249
            31-126              JAXUCZ010000001.1  236885207-236885302
            127-223             JAXUCZ010000001.1  236889688-236889784
            224-336             JAXUCZ010000001.1  236890479-236890591
            337-450             JAXUCZ010000001.1  236895205-236895318
            451-1544            JAXUCZ010000001.1  236896600-236897693
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1544
                     /gene="Mlana"
                     /note="melan-A"
                     /db_xref="GeneID:293890"
                     /db_xref="RGD:1306525"
     exon            1..30
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            31..126
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Mlana"
                     /note="upstream in-frame stop codon"
     CDS             56..685
                     /gene="Mlana"
                     /note="isoform 2 is encoded by transcript variant 2;
                     melanoma antigen recognized by T-cells 1"
                     /codon_start=1
                     /product="melanoma antigen recognized by T-cells 1 isoform
                     2"
                     /protein_id="NP_001424469.1"
                     /db_xref="GeneID:293890"
                     /db_xref="RGD:1306525"
                     /translation="MPREEVHFGYPRKGHSHSYITAEEAAGIGILVVALGIALLIGCW
                     YCRRRSGYRALTDPGSVPSNHTVAHSPPKLQSQRICQPLLVSRVTRNAQWTKGVMLVL
                     KIPPGKDAYVRVLITKTADCLLKKKTTNLWFPTLHLPMRSSLQTTRHHHIHPESREAA
                     KNSESFLHAFALRLSRCPCFALECYRMYSYTNRPGLNSWQGKQKGGEEW"
     misc_feature    59..307
                     /gene="Mlana"
                     /note="Protein melan-A; Region: MLANA; pfam14991"
                     /db_xref="CDD:464426"
     misc_feature    59..307
                     /gene="Mlana"
                     /note="Protein melan-A; Region: MLANA; pfam14991"
                     /db_xref="CDD:464426"
     exon            127..223
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            224..336
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            337..450
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1544
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagcaggg aggactgctc ctcaaggaag gtgtcctgtg ctctgagttc acacaatgcc
       61 ccgagaagaa gttcacttcg gttatcccag gaaggggcac agccactctt atatcactgc
      121 tgaagaggcc gcagggattg gcatcctggt tgtagccctg gggattgctc tgctaatcgg
      181 ctgctggtat tgcagaagac gaagtggata cagagccttg acggacccag gttcagttcc
      241 cagcaaccac acggtggctc acagccctcc gaaactgcag tctcagagaa tctgtcaacc
      301 tcttctggtc tccagagtca ccaggaatgc acaatggaca aaaggcgtca tgctggtact
      361 caaaatacct ccagggaaag atgcttatgt gagagtcttg atcaccaaga cagccgactg
      421 tcttctcaag aaaaaaacca ccaacctgtg gttcccaacg ctccacctgc ctatgagaag
      481 ctctcttcag accactcgcc accaccatat tcaccctgag agccgagaag ctgctaagaa
      541 ttctgaaagt ttccttcatg ctttcgcttt aaggctgagt agatgcccat gttttgcttt
      601 agaatgctat agaatgtaca gctatactaa caggccaggg ttaaattctt ggcagggcaa
      661 gcagaagggt ggcgaggaat ggtgagaaat attaaccttg gaaaagcgtc aataaatatc
      721 tcaacgtata ttatctgtcc cagtggcaat gccattaaat catcattgtt agcattgttt
      781 tgaggggtga actcacctgg atgaccaggg agcctctgat ttgcaaagaa atttttatct
      841 ttatgtgtgc ccacatttat gtatgtgcat ttgcatgctg attcctgctg aagccggaaa
      901 ctgttagatt ccctggagtc ggagttacag gaggctttga gctgcctcct gtgcgtgccg
      961 gaactaaatg agttctctga aggagcaggg agcactttta acaatgcagc cacctcttct
     1021 gactttctcc tgcttcctaa aatgaaacgc agctagcttt caaactactc ttcagctttt
     1081 aaaagcaacc tattggccag tgtgagctgt gcagaattgc cacagatgtt atgggctgtt
     1141 cagaaaggat cccgttacag gtttaaaaca acttgcttct gctggacaat gttaaccacg
     1201 gtgctctgtg ttctaaaggg atcccacagt aacacattgt aaagtttctc tctctctcct
     1261 ccctccactt ctctctctcc gtggttatgt atttgtgagg actgaggtca gtgttgggta
     1321 ggtttttttg acagtctctc agcaaaccct gagttcattg gtttggctaa tcggccaggg
     1381 agcctcaaat acccacccgt gtccactgct cagttctgga gttaatgtgc ttccacacct
     1441 taccattatg cgtggactct ggggttccaa agtctcaagc tcgtgtggca ggcatcttac
     1501 aaactaagcg atcttctcag cagaaaataa aatgaacaaa tata
//
LOCUS       NM_001437528            3384 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 3, mRNA.
ACCESSION   NM_001437528 XM_017601030
VERSION     NM_001437528.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017601030.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37634.1,
                                           SRR26643290.51322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               JAXUCZ010000018.1  30382855-30383363
            510-679             JAXUCZ010000018.1  30385958-30386127
            680-841             JAXUCZ010000018.1  30386679-30386840
            842-993             JAXUCZ010000018.1  30387819-30387970
            994-1536            JAXUCZ010000018.1  30394747-30395289
            1537-1765           JAXUCZ010000018.1  30396391-30396619
            1766-1938           JAXUCZ010000018.1  30399772-30399944
            1939-2069           JAXUCZ010000018.1  30401686-30401816
            2070-3384           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3384
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..509
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            510..679
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    628..630
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            680..841
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             688..2127
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 3"
                     /protein_id="NP_001424457.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTA
                     QASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCF
                     NSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCS
                     SVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAIC
                     SSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKA
                     LEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKH
                     FTDPDSPCFNRLFHAVDVNGDIWEDEIED"
     misc_feature    712..1092
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    712..1092
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    1339..1515
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1339..1515
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1600..1770
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1600..1770
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1867..2070
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1867..2070
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            842..993
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1536
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1765
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1938
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2069
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3384
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggtgcc cggtgactgc aggcctggct ggctagcgtg ttgcgagggc cccagtcaag
       61 ggcatactgc ggaactttcg ggcccggctc agctaagcgg ccggaaggta cggcggggag
      121 gcgctgtgag cgcgcgaggc cgagccgagt ggccgggcct gctctgtgga cactcggctc
      181 cctgcccggg acagagcggg gaggccggct ccgtgggccc tgagggtaca gggcggggcg
      241 gatgggccct gcggctgccg cacgcccggg gaacagttcc tctacgccat tgctagcccc
      301 gggcctatag ccctgcctga tcctgtcggg tgttgcttgg gagtcgtaca aatacgtctg
      361 catggcgatt ggcagactgc ggagagagag acccaggctg accccagcgc tggagcctgc
      421 agggagtggc cgggaagatg aataggattt tcccaagcta gggaaagctg gcggaggagg
      481 ggcttcacgt cctgctggag tggcttccga tggcagaatt tctgtagtat attggatgca
      541 aatcccacat cttggtttct tatccagctt cagtctagct tcactggcta gaaaataaat
      601 gggatttgca caaattccaa gccacagtga aataacgctt gcagcattga tatccttttc
      661 tcctcgttgt tactaacaga aaattcaatg tcggcagaag acctggaagc ccaggaggat
      721 gaactactgg ccctggcaag tatttatgat ggagatgagt ttagaaaagc agagtctgtc
      781 caaggagggg aaaccaggat ctatttggat ctgccacaga atttcaagat attcgtgagc
      841 ggcaattcaa atgagtgtct ccagaatagt ggctttgaat acaccatttg ctttctgcca
      901 ccacttgtgc tgaactttga actgccacca gattatccat cctcctcccc accttcattc
      961 acacttagtg gcaaatggct gtcaccaact cagctctctg ctctctgcaa gcacctggac
     1021 aacctgtggg aagaacaccg aggccgtgtg gtgctgtttg cctggatgca gtttcttaag
     1081 gaggagaccc ttacctacct gaatattgtc tctccttttg agctcaagat ggggtctcag
     1141 aaaaaggttc agagaaggac aacagctcag gcctcttcca acacagagct tgctttggga
     1201 ggagctgctg ctgctgctgc tgcgtcagat gtagaccaag aagacagtgt ggatgagaga
     1261 gctgtacagg atgtagaatc attgtcaagt ctgatccagg aaatcttgga cttcaatcaa
     1321 gatcgacaga tgaagtgctt caatagtaaa ctgttcttgt gcagtatctg tttctgtgag
     1381 aagctgggga gtgattgtat gtacttcttg gagtgcagac atgtatattg caaagcctgt
     1441 ctgaaggatt actttgaaat ccagatcaaa gatggtcaag ttaaatgcct caactgtcca
     1501 gaaccacagt gttcttcggt ggctactcct ggtcaggtca aagagctggt agaagcagac
     1561 ttatttgctc gctatgaccg cctcctcctc cagtctactt tggatctaat ggcagatgtg
     1621 gtgtattgtc cccgtccatg ctgccagctc cctgtgatgc aagagcctgg tggcaccatg
     1681 gctatctgct ccagctgcaa ttttgccttc tgcaccttat gcagactgac ctatcacggg
     1741 gtttctccat gtaaggtaac ggcagagaaa ttaatagact tacggaatga atacctacaa
     1801 gcagatgaag ctactaaaag gttcttggaa cagaggtatg gcaagagggt gattcagaag
     1861 gccctggagg agatggagag taaagactgg ctggagaaga actccaagag ctgcccctgc
     1921 tgtggaacgc ccatacagaa attagacggc tgcaacaaga tgacctgtac tggctgtatg
     1981 cagtatttct gctgggtttg catgggctct ctctcaagag caaaccctta caaacatttc
     2041 actgatcctg attctccatg ctttaacagg ttgttccatg ccgtggatgt caatggagac
     2101 atttgggaag atgagattga ggactagttc attcctgctc gcaatgtaga aatggaatgg
     2161 tttgccctga ccttctgtca agtacacaaa gagccctcgc aggatattta gggtaccatc
     2221 tattcactct tcagtgtaga aggaagaaca gggtttatat tttcctttgg ttctactgat
     2281 taaggcacgt acatttccat gtaacataat ctgataaaat tatatgccaa aggatcagaa
     2341 atgaaaacta tagattaaat attataatat gcccaaactg tgaatagtta aaaagtaaat
     2401 atttattttc tcccccaagc tttaggttag ggagagggtc aagagttaag cttttagacc
     2461 atgtccaaga agcccctgca gctggggaca gtcacagccc cagccacact gtcctgggag
     2521 cctgatccat tctctgtaca ctgctcattt ccattcgtgc tttggagaga gcctctgctc
     2581 tgtaactgac caaatgtcca gtgttgttct gttgtactgc ttgccagaat agaaatctat
     2641 aataaattaa aaaatatttt tagtattata atccctgtgg gtcacttgat atttatgaat
     2701 agtgtattga atcccctggt ttagagccaa atgtagaatt taggattctg gctcagaatt
     2761 cctctagatt cagagtcaga gctgtctgtg ctcccttttg ttctcagctt tctccctttg
     2821 cctcccacct tctgttggca agtacagttt taatgttgat tacagcagtg tgtgtcttta
     2881 tttcctctgc tagaatagaa aagagcccaa tatattcctc atgaatgctc tctgaacctg
     2941 tgaacagcat catggttcta ccccaccttc tgaacactcg ggaattgggc ttcctcccct
     3001 cccctcccct cgtagacagc agtgtttgga gtgataatag tagcttgata gctagattcc
     3061 taaccctggc ttttattggc tttttgaaaa actgtcttcc tcctgattcc ctaagtggct
     3121 tggtgtagtc acttggtgga tgttttggaa aggacagtaa ctcacctgta gcttgtgaac
     3181 ttgtgttttc tactgtgaca ttgaaaatta aggattgctt aactgtcagc tcaaactgtt
     3241 gctggattgt caatgaggat gcttaatctt aacaataaag taatttaaaa tcatcccgta
     3301 attggagtag gcatggtgtc tgttgcttct gtcaccaaag cactgactga attaaaactg
     3361 actgtgtttc tgtttgttct gtta
//
LOCUS       NM_182955               3151 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 24 (Zfp24), transcript
            variant 1, mRNA.
ACCESSION   NM_182955 XM_214606
VERSION     NM_182955.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Howng,S.Y., Avila,R.L., Emery,B., Traka,M., Lin,W., Watkins,T.,
            Cook,S., Bronson,R., Davisson,M., Barres,B.A. and Popko,B.
  TITLE     ZFP191 is required by oligodendrocytes for CNS myelination
  JOURNAL   Genes Dev 24 (3), 301-311 (2010)
   PUBMED   20080941
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Wang,H., Sun,R., Liu,G., Yao,M., Fei,J. and Shen,H.
  TITLE     Characterization of the target DNA sequence for the DNA-binding
            domain of zinc finger protein 191
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 40 (8), 704-710 (2008)
   PUBMED   18685786
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Wu,Y., Yu,L., Bi,G., Luo,K., Zhou,G. and Zhao,S.
  TITLE     Identification and characterization of two novel human SCAN
            domain-containing zinc finger genes ZNF396 and ZNF397
  JOURNAL   Gene 310, 193-201 (2003)
   PUBMED   12801647
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Albanese,V., Biguet,N.F., Kiefer,H., Bayard,E., Mallet,J. and
            Meloni,R.
  TITLE     Quantitative effects on gene silencing by allelic variation at a
            tetranucleotide microsatellite
  JOURNAL   Hum Mol Genet 10 (17), 1785-1792 (2001)
   PUBMED   11532988
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_182955.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49530.1,
                                           SRR26643285.51629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000018.1  15581890-15582006   c
            118-617             JAXUCZ010000018.1  15578901-15579400   c
            618-765             JAXUCZ010000018.1  15578524-15578671   c
            766-3151            JAXUCZ010000018.1  15573031-15575416   c
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3151
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zinc finger protein 24"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
     exon            1..117
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            118..617
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    147..149
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="upstream in-frame stop codon"
     CDS             198..1304
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zfp-191; zinc finger protein 191"
                     /codon_start=1
                     /product="zinc finger protein 24"
                     /protein_id="NP_892000.1"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
                     /translation="MSAQSVEEDSILIIPNPDEEEKILRVKLEEDPDGEEGSSISWNH
                     LPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVA
                     ILPRELQTLVREHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEEIASQED
                     AQGLPSSELDAVENQLKWASWELHSLRHCDDDATAENGALAPKQEIASAGESHEVPGT
                     LNIGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGE
                     KPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKP
                     YECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV"
     misc_feature    339..674
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    339..674
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    591..593
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    621..623
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    <942..1184
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <942..1184
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    948..1100
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNK3.1);
                     Region: Necessary and sufficient for nuclear localization.
                     /evidence=ECO:0000250"
     misc_feature    954..1016
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    954..1016
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(969..971,975..977,981..983,987..992,999..1004,
                     1011..1013,1053..1055,1059..1061,1071..1076,1083..1088,
                     1095..1097,1137..1139,1143..1145,1149..1151,1155..1160,
                     1167..1172,1179..1181)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(969..971,975..977,981..983,987..992,999..1004,
                     1011..1013,1053..1055,1059..1061,1071..1076,1083..1088,
                     1095..1097,1137..1139,1143..1145,1149..1151,1155..1160,
                     1167..1172,1179..1181)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1017..1019
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1038..1100
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1038..1100
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1071..1073
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1110..>1271
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1110..>1271
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1122..1184
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1122..1184
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1200..1202
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1206..1268
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1206..1268
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            618..765
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            766..3151
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggaagcg gctgaaagcg gcggcgcagc gtctgcccgg gacgacgagg ctgtggcggg
       61 tcccgagcca gaggtcagca gcgcgcgggg gtagggttcg aggaggcggg ggctcaggag
      121 tacttttgag gaaaacaggg tatttctgag gtctgtacct tgcctcagtt gccttttctt
      181 ggaggtattg taacaggatg tctgcccagt cagtggaaga agattcaata cttatcatcc
      241 caaatccaga tgaagaagaa aaaattctga gagtgaaact agaggaggat cctgacggtg
      301 aagaaggatc gagcatttcc tggaaccatc tccctgaccc ggagattttc cggcagcggt
      361 tcaggcagtt tggataccag gattcaccag gaccgcgaga ggcggtgagc cagctccgag
      421 aactgtgccg cctgtggctc agaccggaga cgcacacgaa ggagcagata ctggagctgg
      481 tggttttgga gcagtttgtc gccatcctcc ccagggagct acagactttg gttcgagagc
      541 atcacccaga gaacggagag gaggcagtga ctgttctaga ggacttggag agtgaacttg
      601 atgaccctgg acagccggtt tctctccgtc ggcggaaacg ggaagtactt gtagaagaga
      661 tagcatctca agaagacgct cagggattac cgagttctga gcttgacgcc gtagagaacc
      721 agctcaagtg ggcatcctgg gaactccact ctctgaggca ctgtgatgat gatgctacgg
      781 cagagaatgg agccctggcc ccaaagcagg agatcgcttc agcgggagag tctcacgagg
      841 ttcctggcac tctcaacata ggtgttcctc agattttcaa atatggagaa acctgttttc
      901 ccaagggcag gtttgaaaga aagagaaatc cttccagaaa gaaacaacac atatgtgacg
      961 agtgtgggaa acacttcagt cagggctctg cccttattct tcatcagaga atccacagcg
     1021 gggagaagcc ttacggatgt gtcgaatgtg ggaaagcctt cagcagaagc tccatcctgg
     1081 tgcagcacca gagagtccat actggagaaa aaccctacaa gtgtctcgaa tgtgggaaag
     1141 cctttagcca gaattctggg ctcattaacc atcagcgaat ccacactggg gagaaaccgt
     1201 atgaatgtgt tcagtgtggg aaatcctata gtcaaagctc aaatcttttt agacatcaga
     1261 gaagacacaa tgcagaaaaa cttttaaatg ttgtgaaggt ttaagaaatt atgaggaaac
     1321 aatcagcact caggtctttt tcttcagaaa tgaagacaaa attaaaaagt gaagagatat
     1381 ggaaactatt tttccccatt gactgagaaa atctactggg aaataaaaaa aaaaaaatct
     1441 tcattcacca ttattacctt gaaagaaatg gtgttatacc tgcctagaaa ccgaaatttt
     1501 aaataattca ggtgttaata acctaaattt tccatgtgat gtttatattt tctttttttc
     1561 tccccaagta attagatgcc tggttctctg tccctcccct ttttcagaca gctactttat
     1621 ttctgtgttg atcactggag gggtgttctg tgagggtgca cacctttttg ttttaaaggg
     1681 caacacagga attgtaaaat ctaaagccca tcttcaaggt ttagaaccat ccttgaaagc
     1741 ttagcttcct tttgttcagg ttgagaagat aacggccaaa gccgcagtca gataagcctt
     1801 aagtctcaga cgagagatgg cagcaaaact tccaggagcg gagggacaac tggggaagtt
     1861 ccctggtgaa gcatgtctct taagtacagt cagtctacag gaaacctcca aaggaaaaag
     1921 tgattttacc taacttgtgg gaatcttact aactaaaatg gttttcctgt gtaaacacag
     1981 acaattgtag aagtgatggt aaatcaaaca ctaaggaaga atgtagtgat attgaaaggc
     2041 aaatgtaaaa ttaaagtaat tatatgtatg acatggcttt tagaaaaatt cttaactcat
     2101 tttgcctcat cctagttaag gacagggaat tccgtgatag ggtgggcagc aatatcaggt
     2161 ttgctatttt tattcctttg gtacaaaagg gttgaacacc aggctaaaac agccatacat
     2221 ttcttattaa acgtttctac tgacagtgca ctgtgctggg tactgtaatc ctacctaagc
     2281 aggtaggtat tcgctccact gtaagtcatg aggggtttcc ccatcaccat tcccagccac
     2341 ctctgagagc gccagagctg tagttctctt gccagtgtgt tgtgtttgga gggagagcta
     2401 gctggtcagc tcttagcgtt cttcagagct gagctcaaga cacactctta gtttgaaagt
     2461 ttatgaatct taaaaatcca aacatttcta gtagcattgt ggttgtagct acacattgaa
     2521 tggactgtac tttaaacaac taagctatta attactagtt tattaacggt cagaattgat
     2581 tttctaatct acagtcttaa cacatttttt taaagaagta ttaaaagtaa tacattttag
     2641 tagtaggatt ctgtatgcct tggctaagaa tccaagtact gtggttctac tgtttaatgg
     2701 aaaactctgg aagttaaagc agtgggtaag agaagaggtt ttgtttggtt ttgttttgtt
     2761 ttgtatgtaa gacaggcatt gttacatgga aaattatcca tgcaagtaca aatattttat
     2821 agctccagtt atttgggtcc tatctggtgc ttcgtcaaat tttaacgtga aaagtgaggt
     2881 ttttgagtga acctggtgaa aagcagtaaa aaatgcagca ccgctgctga ggtgaggcag
     2941 aatgacgctt gttcatgatt ttctgagaac aattataaga aatgtgcttt atagatgaag
     3001 atttattgag gtataaatat gtagtaatgc tataatgtat ttttaagtta tacaagaaaa
     3061 tgtagggact tttgtttggg tctttctctg tggctgagag gaaacaagtt aatgtccaat
     3121 aaagctggaa actcctctgc tctaagataa a
//
LOCUS       NM_001437449            1858 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 7, mRNA.
ACCESSION   NM_001437449 XM_006229019
VERSION     NM_001437449.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229019.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-729             JAXUCZ010000001.1  104572222-104572332
            730-1016            JAXUCZ010000001.1  104572931-104573217
            1017-1211           JAXUCZ010000001.1  104574234-104574428
            1212-1385           JAXUCZ010000001.1  104574810-104574983
            1386-1521           JAXUCZ010000001.1  104576616-104576751
            1522-1678           JAXUCZ010000001.1  104577708-104577864
            1679-1858           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1858
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1650
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 7 is encoded by transcript variant 7; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     7"
                     /protein_id="NP_001424378.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTN
                     VLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCS
                     GPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARW
                     HQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVER
                     SAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQ
                     QLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEAL
                     SSTLRLAQDEAVRAKNLLLTDKMKPE"
     misc_feature    187..1647
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1647
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    715..717
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    829..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    886..888
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    970..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..729
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1016
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1211
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1385
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1678
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1858
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaaggg cccccgccct gatgttctga cccaggagaa ctgccgcaag
      661 gtgacccgtt cagtggaaga cgctgaaatc aaaaccaatg tcctgaagca gaactctgcc
      721 ttgttggagg agaagctaag atacctccag cagcaactgc aggatgagac gccccggaga
      781 caggaggccg agttgcagga gctggagcaa aaactagagg ctggcctctc ccggcatggc
      841 ctaggcccta ctactcccat tcagggctgc tccggtcctc ctggtagccc ggaggaaccc
      901 ccgcggccgc gaggcctgcc ctccaatggc tggggcatgg caatccgcgc aggggaggga
      961 ccctcgctga gcgagcagga gttgcagaag gtctccagcg gcctagagga gctgaggagg
     1021 gaggtgtcct cgctggcagc tcggtggcat caggaggagg gggcggtgca ggaggcccta
     1081 aggttgctgg gaggcctggg cggccgtctg gatggctttc tgggccaatg ggagcgggcg
     1141 cagcgggaac aagcacagtc cgcacggggt ttgcaggagc tgcgaggacg agcagatgag
     1201 ctgtgcacta tggtggagag gtcagcagtg tctgtcgctt cactgaggag cgaactggag
     1261 gcactgggcc cagtaaaacc gattctggag gagctgggac ggcaacttca aaactcccga
     1321 aggggacctg accatgtctt gaacttggat cgtcctgccc aaggtccctg tcctcgatgt
     1381 gccagccagg ggcagcagtt atccacggag tccctacagc agctgctgga acgtgcgctg
     1441 accccactgg tggacgaagt gaagcagaag ggtctggctc ctgcctgccc cagttgccag
     1501 aggctacaca agaagattct ggagctggag cgccaggcct tggccaaaca cgtcagggca
     1561 gaggccctga gctccaccct tcggctggcc caagacgaag ccgttcgggc caagaaccta
     1621 ctgctgacgg acaagatgaa gccggagtga ggacggaggc agagggcatg ggaggagggg
     1681 agaaggtggc cactttggac tatatgcatt tgaagatgtg ttccctccac gaccaactca
     1741 gccacctgcc acttgagggg tccacagggg caatgggggg aggaagcact ggaggggctc
     1801 cccctaaacg tgggggtcca ggctctgaac aataaatggc ctctcatgct ggcatgaa
//
LOCUS       NM_001437497            6851 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 6, mRNA.
ACCESSION   NM_001437497
VERSION     NM_001437497.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6851)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6851)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6851)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6851)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6851)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6851)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6851)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6851)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6851)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6851)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2149575.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-4066           JAXUCZ010000001.1  128277918-128278787 c
            4067-4164           JAXUCZ010000001.1  128277712-128277809 c
            4165-4392           JAXUCZ010000001.1  128276273-128276500 c
            4393-4559           JAXUCZ010000001.1  128271583-128271749 c
            4560-5034           JAXUCZ010000001.1  128266965-128267439 c
            5035-5252           JAXUCZ010000001.1  128265159-128265376 c
            5253-5357           JAXUCZ010000001.1  128263816-128263920 c
            5358-6851           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..6851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6851
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5452
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 6 is encoded by transcript variant 6; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 6"
                     /protein_id="NP_001424426.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASR
                     DLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHP
                     RDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHN
                     RYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLI
                     PSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDV
                     NDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRS
                     NHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSK
                     GKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNS
                     VSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKT
                     ITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKA
                     HSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVAT
                     ARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETL
                     LSPLVMCGPHGLKFLKPVELRLPHCASMTPDGDPKTWQNKCLPGDPNYLVGANCVSVL
                     IDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    5078..5419
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     misc_feature    5078..5419
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..4066
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4164
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4392
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..5034
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5252
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5357
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..6851
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3241 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3301 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3361 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3421 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3481 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3541 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3601 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3661 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3721 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     3781 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     3841 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     3901 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     3961 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4021 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4081 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4141 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4201 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4261 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4321 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4381 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4441 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4501 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4561 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4621 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4681 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4741 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     4801 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     4861 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     4921 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     4981 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5041 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5101 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5161 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5221 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5281 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtgc
     5341 gtccatgact cctgacggtg accctaaaac ttggcaaaac aagtgtcttc ctggagatcc
     5401 gaattacctt gttggagcca actgtgtttc tgtcctgatt gaccactttt aattcttaga
     5461 gtctagcagc tggactaagc agtgtgaaca tggattgaac ttactgaatg gaaccactct
     5521 aatgagtatt ctattttctt agaatttata ctgcagttag tagtattaaa catttgttgg
     5581 aactgataaa ggttagtgag catgcccctg aaccacgatc agaaaacatg ctacaagctg
     5641 tgtgttattg agtggagaac tgtcaggcat tggctagagg ttcaaagata ttttgctttg
     5701 taatgatttt tgtacttttt tatggtcact gcttaacttc acatactgat ttccgttaaa
     5761 aataccagcc agtaaatggg ggtgcatttg agttttgttc tttccaaagt acactcaacc
     5821 tttactatgg ccttggccta gcatacacat ttattttatt atgcatgagg taatgtgcac
     5881 acatttttta caaatgcacc tggaatatat aaccagtgta gtggatttaa cagaaatgta
     5941 cagcaggggg atttataact tggggaggga ggggcaaatg aagacaattc cttattgtat
     6001 atgaaaacac atttctctta gggaaggaca ccaaagcatg tgagcccagt tccatggccg
     6061 ctgaatctat aaattaacat atcaccacag acatccaacc agcaggaatg ccttaccctc
     6121 atggttttca ttcttagatc atttcgctct gtagtactaa gtttttatga gtttgtgcgt
     6181 acctagatac tgtatcatgg aaaagactga ggaaattgtg gacttgatgg tttcggaaat
     6241 gtgtaaatca cctggaagaa agtaatggtg tgacttaaaa tatttttttt tgacaaggga
     6301 gagtggttgg tggtcttctg ttctttgggc tatgcatctg agatgtttga tgtgttcagg
     6361 acgcatgtac ataatgcgtg cataccactt ttgttcttgg tttgtaaatt aacttttata
     6421 aactttacct ttttatacat aaacagaacc gagtttctaa ggctaccttt gtattctctc
     6481 ctgtacctct tgagccttga actttgacct ctgcagcaat aaagcagcat ttctacacat
     6541 ataaggtcat ttttttaaga aaaagaatgc acagagttgt tacattttta agtgctgcat
     6601 ttaaaagata cagttactct agtttgatta aattcttgca aagtatccct tctgtaaaat
     6661 ttgtgataca atgctgtgcc ctaaagtgta tttttttact aatagtttat tatggcacat
     6721 cagcacgatt tctgtttaga taatacacca ctacattctg ttaataatca ttaggtgtga
     6781 aaggatttct tttgtggtta ttaaaaatct caaatttcta aatctgcaag aataaaactt
     6841 tttaaaatac a
//
LOCUS       NM_001130013            5890 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CDC42 binding protein kinase gamma (Cdc42bpg),
            transcript variant 2, mRNA.
ACCESSION   NM_001130013 XM_001071634 XM_219530
VERSION     NM_001130013.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5890)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   2  (bases 1 to 5890)
  AUTHORS   Ng,Y., Tan,I., Lim,L. and Leung,T.
  TITLE     Expression of the human myotonic dystrophy kinase-related
            Cdc42-binding kinase gamma is regulated by promoter DNA methylation
            and Sp1 binding
  JOURNAL   J Biol Chem 279 (33), 34156-34164 (2004)
   PUBMED   15194684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001130013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.5793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  213037913-213038250
            339-430             JAXUCZ010000001.1  213040617-213040708
            431-514             JAXUCZ010000001.1  213040790-213040873
            515-610             JAXUCZ010000001.1  213041214-213041309
            611-759             JAXUCZ010000001.1  213041709-213041857
            760-853             JAXUCZ010000001.1  213042483-213042576
            854-1054            JAXUCZ010000001.1  213042713-213042913
            1055-1303           JAXUCZ010000001.1  213043008-213043256
            1304-1383           JAXUCZ010000001.1  213043655-213043734
            1384-1481           JAXUCZ010000001.1  213044724-213044821
            1482-1562           JAXUCZ010000001.1  213044920-213045000
            1563-1669           JAXUCZ010000001.1  213045199-213045305
            1670-1849           JAXUCZ010000001.1  213045401-213045580
            1850-1933           JAXUCZ010000001.1  213045784-213045867
            1934-2055           JAXUCZ010000001.1  213046010-213046131
            2056-2131           JAXUCZ010000001.1  213046216-213046291
            2132-2238           JAXUCZ010000001.1  213046509-213046615
            2239-2353           JAXUCZ010000001.1  213046692-213046806
            2354-2502           JAXUCZ010000001.1  213047105-213047253
            2503-2591           JAXUCZ010000001.1  213047330-213047418
            2592-2644           JAXUCZ010000001.1  213047654-213047706
            2645-2743           JAXUCZ010000001.1  213047796-213047894
            2744-2803           JAXUCZ010000001.1  213047975-213048034
            2804-2909           JAXUCZ010000001.1  213048285-213048390
            2910-3043           JAXUCZ010000001.1  213048661-213048794
            3044-3183           JAXUCZ010000001.1  213048876-213049015
            3184-3265           JAXUCZ010000001.1  213049110-213049191
            3266-3482           JAXUCZ010000001.1  213050234-213050450
            3483-3545           JAXUCZ010000001.1  213052197-213052259
            3546-4145           JAXUCZ010000001.1  213052355-213052954
            4146-4243           JAXUCZ010000001.1  213053894-213053991
            4244-4328           JAXUCZ010000001.1  213054074-213054158
            4329-4449           JAXUCZ010000001.1  213054275-213054395
            4450-4567           JAXUCZ010000001.1  213054497-213054614
            4568-4691           JAXUCZ010000001.1  213054813-213054936
            4692-4777           JAXUCZ010000001.1  213055053-213055138
            4778-5890           JAXUCZ010000001.1  213056652-213057764
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5890
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CDC42 binding protein kinase gamma"
                     /db_xref="GeneID:293693"
                     /db_xref="RGD:1307260"
     exon            1..338
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4834
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase MRCK gamma; CDC42 binding
                     protein kinase gamma (DMPK-like)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform 2"
                     /protein_id="NP_001123485.1"
                     /db_xref="GeneID:293693"
                     /db_xref="RGD:1307260"
                     /translation="MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRE
                     RNVAQFLSWAGPFVTKVKELRLQRDDFEILKVIGRGAFGEVAVVRQRDSGQIFAMKML
                     HKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLL
                     SRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCL
                     RLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF
                     YAESLVETYGKIMNHEDHLQFPSDVDDVPASAQALIRQLLCRQEERLGRGGLDDFRSH
                     PFFEGVDWERLATSTAPYIPELRGPVDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLP
                     FVGFTYTSGSLTDDKSSELMATPEWKPHGVEQMKVELSQKCQEALHSSLQPQELVRLQ
                     KEVQVLQEKLTETLRDSKASLSQADGLHVRSPAPDIQLQQEKDRLQQELAEAQAALQV
                     RDAELCQAQNRQEEFLQRLWEAQEREAAAASQIQALNSQLEEAWVVRRELEGQVNTLS
                     QEVTQLQGQCKQDSSSQAKTVHAAPETNGIGSPEGQSQEAQLRKEVAALREQLECACS
                     QGVNVGKEEVLCRLQEENQRLSREQERLAEELDLELQSRQRLEGERRESESNWEAQIA
                     DILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPTRPLDHQWKARRLQKMEAS
                     ARLELQSALEAEIRAKQGLQEQLTQVQEAQRQAERRLQEAEKQNQALQQEVAELREEL
                     QARGPGDAKPCTSLIPLLSFWNTEKDSAKDPGNSGESPRSGAEAELRPEGRRSLRMGS
                     VFPRVPAANPTPAEGPPAKPGSHTLRPRSFPSPTKCLHCTSLMLGLGRQGLGCDTCGY
                     FCHSACATQAPPCPVPPELLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVYAA
                     LSDSRLLLFDAPDPRGSMASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRV
                     TASQLTVPPSTCTVLLLAENEGERERWLQVLSELQRLLLDARPRPRPVYTLKEAYDNG
                     LPLLPHTLCAAIIDRERLALGTEEGLFVIHLHSNDIFQVGDCRRVQRLTVSSAAGLLV
                     VLCGRGPSVRLFTLSELENAEVAGAKIPESRGCQALVAGSILQARTPVLCVAVKRQVL
                     CYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNEAAPLALGT
                     GLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDGAGRKSRSHELLWPVAPT
                     GWGYTAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLLLYGTEKVRLTYL
                     RNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRSKF
                     ISPPTNFNHLVHVGPTEGRPGPRDGTRAQEQKSRGTRSSGPQRPHSFSEALRRPVSMG
                     NDGLPGETDPLKRKVWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESEGSP"
     misc_feature    383..1375
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; Region:
                     STKc_DMPK_like; cd05597"
                     /db_xref="CDD:270748"
     misc_feature    383..1375
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; Region:
                     STKc_DMPK_like; cd05597"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     620..625,629..631,641..643,647..649,761..763,767..769,
                     773..778,782..784,812..817,824..826,869..886,980..982,
                     998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="active site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     620..625,629..631,641..643,647..649,761..763,767..769,
                     773..778,782..784,812..817,824..826,869..886,980..982,
                     998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="active site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     623..631,641..643,761..763,767..769,773..778,782..784,
                     812..817)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     623..631,641..643,761..763,767..769,773..778,782..784,
                     812..817)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(419..421,641..643,647..649,761..763,767..769,
                     773..775,824..826,869..886,980..982,998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(419..421,641..643,647..649,761..763,767..769,
                     773..775,824..826,869..886,980..982,998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(812..844,851..886)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270748"
     misc_feature    order(812..844,851..886)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270748"
     misc_feature    1355..1372
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270748"
     misc_feature    1355..1372
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270748"
     misc_feature    <1514..>2581
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1514..>2581
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    2813..2968
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; Region:
                     C1_MRCKgamma; cd20866"
                     /db_xref="CDD:410416"
     misc_feature    2813..2968
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; Region:
                     C1_MRCKgamma; cd20866"
                     /db_xref="CDD:410416"
     misc_feature    order(2828..2848,2870..2884,2891..2893)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="putative DAG/PE binding site [chemical binding];
                     other site"
                     /db_xref="CDD:410416"
     misc_feature    order(2828..2848,2870..2884,2891..2893)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="putative DAG/PE binding site [chemical binding];
                     other site"
                     /db_xref="CDD:410416"
     misc_feature    2990..3388
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; Region: PH_MRCK;
                     cd01243"
                     /db_xref="CDD:269949"
     misc_feature    2990..3388
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; Region: PH_MRCK;
                     cd01243"
                     /db_xref="CDD:269949"
     misc_feature    3482..4258
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     misc_feature    3482..4258
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     exon            339..430
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            431..514
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            515..610
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            611..759
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            760..853
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1054
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1303
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1383
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1481
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1562
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1669
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1849
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1933
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2055
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2131
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2238
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2353
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2502
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2591
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2644
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2743
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2803
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2909
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3043
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3183
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3265
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3482
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3545
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..4145
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4243
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4328
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4449
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4567
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4691
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..4777
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..5890
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggccag gtgaaggagc gcgggtgtcg acggaggaag gtgacagcgg ggagggcggg
       61 agggaggggg gaagccgagc aggacgagct gcggaaccac ggaccgaccg ccggacggac
      121 ggacggggca tgcgggcggc ctggctctag cccgggttac ggggctccag ccgcagccat
      181 ggagcagcgg ctgcgtgcgc tggagcagtt ggtacggggc gaggctggtg gcagcccggg
      241 gctcgacggc ctcctggatt tgctgctggg ggtgcaccag gagctcagca gcgcccccct
      301 gcgccgggag cgtaacgtgg cgcagtttct gagctgggct ggcccctttg taacaaaagt
      361 gaaagagctg cgtttacaga gagatgactt tgagatcttg aaggtgattg gcagaggggc
      421 ctttggggag gttgctgtgg tgaggcagag ggacagtggc cagatttttg ccatgaagat
      481 gctgcataag tgggagatgc tgaagagggc tgagacggcc tgtttccggg aggagcgaga
      541 tgttctagtg aagggagata gccgctgggt gactgctctg cactacgcct tccaagatga
      601 ggagtacctg tacctggtga tggactacta cgctggcggg gacctcctca cactgctgag
      661 ccgcttcgag gatcgcctcc cacctgagct ggcccagttc tatctggctg agatggttct
      721 ggccatccac tctctgcacc agctgggcta tgtccacagg gatgtcaagc ctgacaacat
      781 cctgctggac atgaatggcc acatccgcct ggcagacttt ggctcctgcc tgcgtctcaa
      841 caacaatggc atggtggatt catcagtcgc agttgggacc ccggactaca tctctcctga
      901 gatcctacag gccatggagg aaggcaaggg ccactacggc ccacagtgtg actggtggtc
      961 cctgggagtc tgcgcctacg agctgctctt tggggaaaca cccttttatg cagagtctct
     1021 ggtagaaacc tacggcaaga tcatgaacca cgaggaccac ctccagttcc cctctgatgt
     1081 agatgacgtg cctgctagtg cccaggccct gatccggcag ctgctgtgcc gtcaggagga
     1141 gcggctgggc cgcggtggac tggacgactt ccggagccac ccgttctttg aaggggttga
     1201 ttgggagaga cttgcaacca gcacagcacc ctacatccct gagcttcgcg ggccggtgga
     1261 tacctccaac ttcgatgtgg atgatgatac cctcaaccgt ccagagacgc tgccaccgtc
     1321 ctcccacggg gccttctcag gccaccacct gccatttgta ggcttcactt atacctcagg
     1381 cagcctcact gatgacaaga gctctgagct aatggctacc ccagagtgga agccccacgg
     1441 tgtggagcag atgaaagtgg agctcagcca gaagtgtcaa gaggccctgc atagctcatt
     1501 acaaccccag gagctggtgc gactgcagaa agaagtacag gttcttcagg agaaactgac
     1561 agagacactg agggacagca aggcctcact ctcacaggct gatggcctcc atgttagaag
     1621 cccagcccca gacatccaac tacaacagga gaaggaccgc ctccagcagg agctggctga
     1681 agctcaggca gcattgcaag tgcgggatgc tgaactgtgc caagcccaga accgacagga
     1741 agaattccta cagaggctgt gggaagccca agagagagag gcagctgcag ccagtcagat
     1801 ccaggccctg aactcccagc tggaggaagc ctgggttgtc cggagagagc ttgaaggcca
     1861 ggtgaacacc ctgagtcagg aggtgacaca gctccaggga caatgtaaac aagactcttc
     1921 ttcacaggcc aagaccgttc atgcagcccc tgagaccaac ggcataggat ctcctgaggg
     1981 tcagtctcaa gaggcccagc tgaggaagga ggtggctgct ctgagggagc agctggagtg
     2041 cgcctgcagc caaggggtca atgttgggaa agaggaggtt ctgtgccgac tgcaggagga
     2101 aaaccagcgg ctgagccggg agcaggaacg gttggcagag gagctggacc tggagctaca
     2161 gagcagacag cgtctggaag gtgagcggcg tgagagtgag agcaactggg aggcgcagat
     2221 tgctgacatc ctcagctggg tgaatgacga gaaggtctcg agaggctacc tgcaggcctt
     2281 ggctactaag atggccgagg agctggagtc cttgaggaat gtgggcaccc aaacactccc
     2341 tacccggcct ctggaccacc agtggaaggc tcggaggctg cagaagatgg aggcctcagc
     2401 ccggcttgag cttcagtcag cactggaagc tgagatccgt gccaagcagg gtctgcagga
     2461 gcagctgacg caggtgcagg aggcccagcg gcaggctgaa cgccgccttc aagaggctga
     2521 gaagcaaaac caggccctgc agcaggaggt ggctgagctc cgggaggaac ttcaagctcg
     2581 aggaccaggg gatgccaagc cctgtacctc cctcatccct ctcctgtcct tctggaacac
     2641 agagaaggat tctgccaagg accctggcaa ttcaggagag tccccccggt ctggagcaga
     2701 agcagagctg aggccagagg gccgccgcag tttgcgcatg gggagtgtgt tccccagggt
     2761 gcctgctgcc aaccctaccc ctgcagaggg tcctcctgct aagcctggtt ctcacacact
     2821 gcgtccccgg agttttccat cccctaccaa gtgtctccac tgcacctcgc tgatgttggg
     2881 cctgggccgc cagggcctgg gctgtgacac ctgtggctac ttctgccact cagcttgtgc
     2941 gacccaagcc ccaccctgcc ctgtgccccc tgaactcctc cgcacagccc tgggggtgca
     3001 cccggaaaca ggcacaggca ctgcctatga gggcttcctg tcggtgcctc ggccttcagg
     3061 tgtccgtcgg ggttggcaga gggtgtatgc tgctctcagt gactcccgcc tgttgttgtt
     3121 tgacgctcct gaccctcgag gcagcatggc cagtggggtc ctcctgcagg ccttggatct
     3181 gagggatccc cagttctcag ccacccctgt cttagctcca gatgtcatcc atgcccaatc
     3241 caaggacctg ccacgcatct ttagggtgac agcctcccag ctgacagtgc caccatccac
     3301 atgtactgtg ctgctgctgg cagagaacga gggggagcgg gagcgttggc ttcaggtgct
     3361 aagtgagctg cagcggctgc tcctggacgc acgcccaagg ccccgaccag tgtacacact
     3421 caaggaggcc tatgacaatg gactgccgct gctgcctcat acgctctgtg ctgctatcat
     3481 tgaccgagag cgtcttgccc tgggcactga ggagggcttg tttgtgatcc atcttcacag
     3541 caatgacatc ttccaggtgg gagactgccg cagggtgcag cggttgaccg tgagctctgc
     3601 cgctggccta ctggtcgtgc tctgtggccg tggtcccagt gtgcgcctct tcaccctgtc
     3661 tgagctggaa aatgcagagg tggcaggtgc caagatccct gaatcccgag gctgtcaggc
     3721 tttggtggct gggagcatcc tacaggcccg gactccagtg ctctgtgtgg cagtcaagcg
     3781 ccaagttctc tgttaccagc tgggcccagg accagggccc tggcagcgcc gcatccgaga
     3841 gctacaagcg ccagctcccg tgcagagcct ggggttgctg ggtgatcggc tctgtgtggg
     3901 tgccgctggc acctttgctc tctacccgct gctcaatgag gctgcgccct tagcgctggg
     3961 aaccggcctg gtggctgagg agctccccgc gtcccgtggg ggcctgggtg aggcactggg
     4021 tgctgtggag ctcagcctca gcgagcttct gctgctcttc gccactgctg gcgtctacgt
     4081 ggatggcgct ggccgcaagt cacgaagcca cgagctgctg tggccagtgg cacccactgg
     4141 ctggggttac acagcaccct acctaacagt gttcagtgaa aactccattg atgtgtttga
     4201 tgtgaggaga gcagaatggg tacagactgt gccactcaag aaggtaagac ccctaaatcc
     4261 agaaggctcc ttgctcctct atggcaccga gaaggtccgt ctgacctacc tcaggaatcc
     4321 attagcagag aaggatgagt ttgacattcc cgacctcacg gacaacagcc ggcgccagct
     4381 gttccgcacc aagagcaagc gccgcttctt cttccgggtg tctgacgagc tgcggcagca
     4441 gcagcgcagg gagatgctga aggacccttt tgtgcgctcc aagttcatct caccgcccac
     4501 caacttcaac cacctggtgc acgtgggccc tacagagggc aggcccggcc ccagggatgg
     4561 gacccgggct caggaacaga agagcagagg cacccgcagc tccggaccgc agcggcccca
     4621 cagcttctca gaggcattgc ggcgtccagt atccatgggc aatgatggcc tccctggaga
     4681 aacagacccc ctgaagagga aagtttggac atctctgtcc agcgaatccg tgtcctgccc
     4741 ccaggggtcc ctgagccctg cagcatccct gatacaggtc tcagaacggc cccggagtct
     4801 ccctccagat cctgagtcag agggctcccc ctgatgccct ctggcagtgc ccaccccatt
     4861 cccaagacag aaggaatgag gaagcaaaga gcttgaggga tgccataccc ggctggtccg
     4921 ggacatgttg aaattcagac tcagggagag cctgggtgga gggctaagag caaggcgcgc
     4981 ctgggtcccc aggagtgggg tctggctcct ggccctattc ctgccattct cctgggcttc
     5041 catcacagcc tacactggcc tctgggagtg ccacgccttt actgcccagg gaagattgtg
     5101 ccaaagctat gcttcatagg gccagggacg cagttagtca ggggaggaat ggagggcggg
     5161 tccttgggag tgtgctggtg tcttgtctgc agcctggccc aggctgaggc cgagatggag
     5221 catgtgaggt ctctgctcag ggtcaggctg ggctctggtt gacaagaaaa ggattgaaaa
     5281 gagagagtga ggtaagtgag agagagagag agaggagagg tgagggagca aaggcagcag
     5341 aggaggaagt gatggaatca ggagatggat gctaactgag aaagaggaga gaaggacaaa
     5401 gcatgtagtg aggaggatgc tggagagaca gaagggaagg agggagaatg agccagggaa
     5461 agcccgaccc aggagctttt ctctagggtg gggctcagga gtgagagcag ggctattgct
     5521 aggttatccg tccaggaaaa atggttccta ggcagggagg ggatgggagg gtatttataa
     5581 gggcttcttg gtgggagata gacacccttc ggggaccact aaatatctcc aggcacacgt
     5641 cggcccttcc cagcaggaag ggtccttttc tggaagcttc aaccaagtgt attaggggaa
     5701 catagggggc attttaatat tgatcacagt cattattatt gttattatat tgctattttt
     5761 attaaacctc gccctgctac agtgtaggga atgaaagaag tatttatctc tttgaatgcc
     5821 acagtcccgg gatggatggg ctctgatgca ccgagatgtg gcaagaaaca ataaagccaa
     5881 ctttacaagc
//
LOCUS       NM_001437434            2085 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Ras and Rab interactor-like (Rinl), transcript
            variant 3, mRNA.
ACCESSION   NM_001437434 XM_006228657
VERSION     NM_001437434.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006228657.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  93204794-93204825
            33-298              JAXUCZ010000001.1  93206590-93206855
            299-401             JAXUCZ010000001.1  93209713-93209815
            402-474             JAXUCZ010000001.1  93211848-93211920
            475-539             JAXUCZ010000001.1  93212006-93212070
            540-686             JAXUCZ010000001.1  93212633-93212779
            687-1163            JAXUCZ010000001.1  93212866-93213342
            1164-1451           JAXUCZ010000001.1  93213660-93213947
            1452-1583           JAXUCZ010000001.1  93214110-93214241
            1584-1747           JAXUCZ010000001.1  93214371-93214534
            1748-2085           JAXUCZ010000001.1  93214620-93214957
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2085
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     exon            1..32
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            33..298
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1792
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="isoform 2 is encoded by transcript variant 3; ras
                     and Rab interactor-like protein"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein isoform 2"
                     /protein_id="NP_001424363.1"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
                     /translation="MTLGLLEPVHSRLSWPLAEGADKSPLRVLSTTESLLRLQRTQRV
                     WQVPELDAEHAKAFLKPWPLGSFLVIGQDPDQVLMLKTGPSSGDINTYQIQKFPGGVS
                     LESSNLCMPDFPHLLAFLSASRDVLPRTLLLPTPTVGPGDKHSDPRRLGCIQVDTSGR
                     VLSVVNQLYLETHGGWETETPQQTKPETGQKRSLAPRMPTPHRVSWVEESLKPEAHHT
                     GQEVHHPERQVHYPGPEAHSLGPEVHFPSPVLEEEEEVNNDSYKDEEEGCEDMLTAHI
                     RALASARSSYVARQYQCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQDYLAKDP
                     DVRAVFGNRGPSIPREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELRRLRRRQ
                     IALRVGAGPEGQSPALRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLAGGENKE
                     PLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWFGALYHI
                     AHYQPDAGRAPQELSSEARASLRQWHRRRTLHQQAQPTAPENQPFEEPWAIGDP"
     misc_feature    212..493
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    212..493
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    order(257..259,311..313,374..376,380..382)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(257..259,311..313,374..376,380..382)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(377..379,458..460)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    order(377..379,458..460)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    1334..1642
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     misc_feature    1334..1642
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     exon            299..401
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            402..474
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            475..539
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            540..686
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1163
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1451
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1583
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1747
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..2085
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct gctcaggctc ccctcggaac agctccatct ttgacctttt gttcctgggc
       61 tatccctgcc tcttggaccc cacctcagtg gccagcctcc accatgaccc ttggcctcct
      121 ggaacctgta cattccaggc tgagttggcc actagcagaa ggagcagaca agagcccact
      181 gagggtcctc agcacgacag agtcacttct tcgactgcag aggacacaga gggtgtggca
      241 ggtccccgag ctggacgctg agcatgccaa ggcctttctc aagccgtggc cactggggag
      301 cttcctggtc atcgggcagg accctgacca ggtcctgatg ttgaagacag gaccttcgtc
      361 aggagatatc aacacctacc aaattcagaa gtttcctgga ggtgtgtccc tggaatcctc
      421 caacctctgc atgccagact ttcctcatct cctggccttt ctgtcagcca gcagggacgt
      481 tttgccaagg actctgctct tgcccacacc tactgtgggg cctggagata agcactcaga
      541 tcctcgtcga cttggctgca tccaggtgga cacctcaggg agggtgctgt ctgtggtgaa
      601 ccagctctac ctggagaccc atggaggctg ggaaacagaa acaccgcagc aaacaaagcc
      661 agaaactggc cagaaacgca gtctagcccc caggatgccc actccacacc gggtctcctg
      721 ggtggaagag tctctgaaac cggaagctca ccatactgga caggaagtgc atcatccaga
      781 aagacaagtg cattatcctg gaccagaagc tcactctctt gggccagaag tacactttcc
      841 tagtcctgtt ctagaagagg aggaagaagt gaacaatgac agctacaagg atgaagagga
      901 aggctgcgag gatatgctca ctgcccacat ccgtgctctg gccagtgccc ggagcagtta
      961 tgtagccagg cagtaccaat gccttcgagc acgactcatc tcagattctg gaaatcccta
     1021 cagcccaggg gacccagcca cagagctgct tcaggatgta cgccagctcc tcactgacct
     1081 ccaggattac ctggcaaaag accccgatgt cagagctgtc tttgggaata ggggacctag
     1141 catccctcgg gaagaagatc ttggccccgc tgtggaggtg gccctgtgtc gagcggttct
     1201 ggagcccctg aagcccgccc tgtggaccaa actccgaact ctcagagccc aggaactgcg
     1261 gcgactgcgc cggcgccaaa tagccttgag ggtaggagca ggacccgagg gacagagccc
     1321 ggccttgcgg aaccgtatcc acgcacgcct cgctcacctg cacgcagcgt gcgccccgcg
     1381 ccgcaaggtg gcgctgttgt tggcggtgtg cagcgatgtc tatgcaggcc tggctggcgg
     1441 cgagaataaa gagcccctgg gggctgacgc ctttttacct gccctgaccg aggagctgat
     1501 ctggagtcca catattgggg aaacacagct ggatgtggag tttcttatgg agctcttgga
     1561 tccaggggag ttgcgaggag aagctgggta ttatcttacc acgtggtttg gggctctcta
     1621 ccacattgct cactaccagc ctgatgctgg ccgtgcaccc caggagctca gctctgaggc
     1681 ccgggcctcc ttgcgccagt ggcaccgaag acggacactg caccagcaag cccagcccac
     1741 agccccggaa aaccagccct ttgaggagcc atgggcaata ggggacccat gatgattgga
     1801 gtcctcaaaa atcagtctcc agaacctttt ggcccactcc tctgctaagc aagattctgg
     1861 aggcatctgg gtcagcacag tgggtggggc agaaaaaagg acgtggcgtt ttgcactggc
     1921 tgttcctact tccttccttc ccctcctggt ctgtccacat gttacctcaa tgaggctctc
     1981 cccagcaaac aaaaccaacg cctaaacaat actacaacta cagccctctc acctgaatct
     2041 ctctggggca ggtagaataa aggcacagtc cccaaaaggt atcta
//
LOCUS       NM_001437516            3068 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 like 4A
            (Epb41l4a), transcript variant 3, mRNA.
ACCESSION   NM_001437516 XM_063277376
VERSION     NM_001437516.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277376.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.424848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000018.1  25888993-25889375   c
            384-821             JAXUCZ010000018.1  25888201-25888638   c
            822-926             JAXUCZ010000018.1  25802641-25802745   c
            927-978             JAXUCZ010000018.1  25773271-25773322   c
            979-1057            JAXUCZ010000018.1  25768091-25768169   c
            1058-1155           JAXUCZ010000018.1  25762381-25762478   c
            1156-1276           JAXUCZ010000018.1  25761136-25761256   c
            1277-1364           JAXUCZ010000018.1  25759154-25759241   c
            1365-1453           JAXUCZ010000018.1  25756917-25757005   c
            1454-1517           JAXUCZ010000018.1  25756320-25756383   c
            1518-1609           JAXUCZ010000018.1  25743152-25743243   c
            1610-1687           JAXUCZ010000018.1  25741649-25741726   c
            1688-1809           JAXUCZ010000018.1  25736039-25736160   c
            1810-1900           JAXUCZ010000018.1  25715494-25715584   c
            1901-1984           JAXUCZ010000018.1  25711524-25711607   c
            1985-2098           JAXUCZ010000018.1  25710913-25711026   c
            2099-2146           JAXUCZ010000018.1  25708322-25708369   c
            2147-2224           JAXUCZ010000018.1  25707400-25707477   c
            2225-2272           JAXUCZ010000018.1  25686822-25686869   c
            2273-2341           JAXUCZ010000018.1  25685951-25686019   c
            2342-2452           JAXUCZ010000018.1  25681986-25682096   c
            2453-2534           JAXUCZ010000018.1  25681789-25681870   c
            2535-3068           JAXUCZ010000018.1  25680164-25680697   c
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3068
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="erythrocyte membrane protein band 4.1 like 4A"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
     exon            1..383
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            384..821
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    699..701
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="upstream in-frame stop codon"
     CDS             723..2669
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="isoform 2 is encoded by transcript variant 3;
                     erythrocyte protein band 4.1-like 4a; band 4.1-like
                     protein 4A"
                     /codon_start=1
                     /product="band 4.1-like protein 4A isoform 2"
                     /protein_id="NP_001424445.1"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
                     /translation="MGCFCAVPEEFYCEVLLLDESKLTLTTQHQGIKKSTKGSVVLDH
                     VFRHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAED
                     PCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQLGAYAIQAELGDHDPCKHTAGYV
                     SEYRFVPDQKEELEESIERIHKTLMGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENK
                     SEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEAR
                     SKTACKHLWKCSVEHHTFFRMPETESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLS
                     IQLPRPNQNVVRSRSKTYPKRVAQTQPAGSNSINRMTANLENGENEGTTKIIAPSPVK
                     SFKKAKNENSPDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPCTRQRNLSCGSDN
                     DSSQPMRRRKAHHSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRRSPDIQA
                     KEELWKHIQKELVDPSGLSEEQLKEIPYTKVETQGDPVRIRHSHSPRSYRQYRRSQCS
                     DGERSVLSEVNSKTDLVPPLPVTRSSDAQGSGGSTVHQRRNGSKDSLIEEKSQLSTTN
                     LAGKHTAKTIKTIQAARLKTDVTG"
     misc_feature    759..1355
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    759..1355
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1341..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    1341..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    order(1365..1367,1416..1418,1422..1424,1440..1442)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1365..1367,1416..1418,1422..1424,1440..1442)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1452..1454,1467..1478,1575..1577,1587..1589,
                     1596..1601)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1452..1454,1467..1478,1575..1577,1587..1589,
                     1596..1601)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1575..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1575..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1653..1787
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     misc_feature    1653..1787
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     exon            822..926
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            927..978
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1057
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1155
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1276
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1364
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1453
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1517
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1609
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1687
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1809
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1900
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1984
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2098
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2146
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2224
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2272
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2341
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2452
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2534
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..3068
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacctgca ggcacccagc cagactgacc acctccgccc cgccctccgc ccccggctga
       61 gaccccgccc tgaagggggg cgctcgggtc accgtcccgg ggctatccag cttcagatcc
      121 gaggcttttt gccgacaccc cgggccggga cccgctgtac ctgggctgct ccctccaggg
      181 ccccgccctg cgcgccacca agaactttcc ctggagcctc ggaggcctgg cgccccgggt
      241 tctgccgcgc cgcccgcagg tcctcagaca cccggctttt ccaggacgtt cggggaagga
      301 agcttgaact tggccatctc cgcgggatga gttcggggac cttcggacag aagctacagg
      361 ccgcgacaag ctgacctccc ccggtcgccg ccccattctt cagaagagga gctgctgccg
      421 caggatgcgc ggggacgcgc cacccctggt tcccagttct gcggacgctt ctcgggcgac
      481 tccgggctct tgacgccccg aggcgcgctc gccctcccgc cttcgctgtc cgagcctctc
      541 ggggtgcctt cggctcacca tagaacccca gaccttaccc tcacccgggg ggccccaccc
      601 agacccgcgc ctctcgccct ctacacggcg cgcacaataa attaatgctt cgcgcttgag
      661 gggaggcggc ggcgggcgcc gcggtcgctg ctctcgcctg actggagacg ctttcagccg
      721 acatgggctg tttctgcgcc gttccggaag aattttactg cgaagttttg ctcctggacg
      781 agtccaagct caccctcacc acccagcacc agggcatcaa gaagtcaacc aaaggttccg
      841 ttgtccttga ccatgttttc cgtcacgtaa acctcgtgga gatagattat tttggtctgc
      901 gatactgcga cagaagccat cagacatatt ggctggatcc cgcaaaaact cttgcagaac
      961 acaaggaact aatcaacact ggacctccgt atactttgta ttttggtatt aaattctatg
     1021 ctgaagatcc atgtaagctc aaagaagaga taaccagata tcagtttttc ttacaggtga
     1081 agcaagatgc ccttcagggc cgtctgcctt gtcctgtcaa tattgccgct cagctgggag
     1141 cctatgccat ccaggccgaa ctgggagacc acgacccatg taagcacact gcggggtacg
     1201 tgtcggagta ccggtttgtt cctgatcaga aggaagaact ggaagaatct atagaaagga
     1261 ttcacaagac tctaatgggt caggctcctt ccgaagctga gctgaattac ttgaggactg
     1321 cgaaatccct ggagatgtac ggcgttgacc tccatcctgt ctatggagaa aataagtccg
     1381 agtatttctt aggattgact ccagtgggtg ttgtcgtcta taagaataaa aagcaagtgg
     1441 ggaagtattt ctggcctcgg attaccaagg tgcacttcaa ggaaacccag tttgaactca
     1501 gagtcttggg aaaagactgt aatgagacct cgttcttttt tgaagctcgg agcaaaactg
     1561 cttgcaaaca cctctggaaa tgcagtgtgg agcaccatac atttttcagg atgccagaaa
     1621 cagagtcaaa ttcactgtca agaaaactca gcaagtttgg gtccataagt tataaacacc
     1681 gatacagtgg caggacagct ttgcaaatga gccgagatct ttccatccaa cttccccggc
     1741 ccaaccagaa cgtggtgaga agtcgaagca agacttaccc caagagggta gcacagacgc
     1801 agcccgctgg atccaacagc atcaatcgga tgactgcaaa cttggaaaac ggggagaatg
     1861 aaggaaccac caagatcatt gcgccctcac cagtgaaaag ttttaagaaa gcaaagaatg
     1921 aaaacagtcc tgacccccaa agaagcaaat ctcatgcacc atgggaagaa aacggacccc
     1981 agagtggact ctacaactcc cccagtgacc gcactaagtc accaaagttt ccctgtaccc
     2041 ggcagcgcaa cctctcctgt ggcagcgaca atgactcctc gcagccaatg aggcgaagga
     2101 aggctcacca cagtggggaa gactcggatc taaagcaacg gaggaggtca cgctcacgct
     2161 gtaacacgag cagtggtagt gagtcagaaa attctaacag agaacaccgg aagaagagaa
     2221 acaggagaag tcctgatatc caagcaaaag aagaactgtg gaagcatatc cagaaggagc
     2281 ttgtggaccc atccgggttg tcagaggagc agttgaaaga gatcccatac actaaagtgg
     2341 agactcaggg tgaccctgtc cgcatcaggc attcgcattc cccaaggagt taccggcagt
     2401 accgcagatc ccagtgctca gacggagagc gatccgtcct ctcggaagtg aactcaaaga
     2461 cagatcttgt accaccactt ccagtcaccc gttcctcaga tgctcagggg tctggaggct
     2521 ctacagttca tcagagaaga aacgggtcta aagacagcct gattgaagaa aaatctcagc
     2581 tttctacaac caacctggct ggaaaacata cagcaaaaac aataaaaacc atccaggctg
     2641 ctcggctcaa gacagacgtc actgggtgaa ggggtgtagg gaaacgtgtg tcactggtac
     2701 ttttcaaact gtgaattaga taattaccca cgtatcttgg actcgtgtcc ttagcacaag
     2761 aaaattggca tcttttaagg atttatgtac agcattcttg tgctgtgggc ctttggaagg
     2821 acaaccttat gaactcactg gataccacca tctctttcct gaaattctga ccatccaact
     2881 gtgtttctca cctctccacc acagccaaga ccagaggctt cagatgagcc cctggactcc
     2941 cagctgccat cagactgtag tgacttttat tcccacaact gtttgtaata ttgtattttg
     3001 tgacatttaa gtcccaatgg ttatttacaa ataatgtaaa aagctgttaa gtgttgattt
     3061 gaatttaa
//
LOCUS       NM_001437456            1766 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 14, mRNA.
ACCESSION   NM_001437456 XM_063284150
VERSION     NM_001437456.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1766)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1766)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1766)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284150.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3012374.1,
                                           SRR26360181.377395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-626             JAXUCZ010000001.1  104572249-104572332
            627-913             JAXUCZ010000001.1  104572931-104573217
            914-1108            JAXUCZ010000001.1  104574234-104574428
            1109-1282           JAXUCZ010000001.1  104574810-104574983
            1283-1418           JAXUCZ010000001.1  104576616-104576751
            1419-1586           JAXUCZ010000001.1  104577665-104577832
            1587-1766           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1766
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1664
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 14 is encoded by transcript variant 14;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     14"
                     /protein_id="NP_001424385.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKL
                     EAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQK
                     VSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSA
                     RGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHV
                     LNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHK
                     KILPSPVSPAAPTLLSPGAGAPGLGQTRQGRGPELHPSAGPRRSRSGQEPTADGQDEA
                     GGEGGHFGLYAFEDVFPPRPTQPPAT"
     misc_feature    135..>1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..>1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..626
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..913
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1108
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1282
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1586
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1766
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 aggagaactg ccgcaaggtg acccgttcag tggaagacgc tgaaatcaaa accaatgtcc
      601 tgaagcagaa ctctgccttg ttggaggaga agctaagata cctccagcag caactgcagg
      661 atgagacgcc ccggagacag gaggccgagt tgcaggagct ggagcaaaaa ctagaggctg
      721 gcctctcccg gcatggccta ggccctacta ctcccattca gggctgctcc ggtcctcctg
      781 gtagcccgga ggaacccccg cggccgcgag gcctgccctc caatggctgg ggcatggcaa
      841 tccgcgcagg ggagggaccc tcgctgagcg agcaggagtt gcagaaggtc tccagcggcc
      901 tagaggagct gaggagggag gtgtcctcgc tggcagctcg gtggcatcag gaggaggggg
      961 cggtgcagga ggccctaagg ttgctgggag gcctgggcgg ccgtctggat ggctttctgg
     1021 gccaatggga gcgggcgcag cgggaacaag cacagtccgc acggggtttg caggagctgc
     1081 gaggacgagc agatgagctg tgcactatgg tggagaggtc agcagtgtct gtcgcttcac
     1141 tgaggagcga actggaggca ctgggcccag taaaaccgat tctggaggag ctgggacggc
     1201 aacttcaaaa ctcccgaagg ggacctgacc atgtcttgaa cttggatcgt cctgcccaag
     1261 gtccctgtcc tcgatgtgcc agccaggggc agcagttatc cacggagtcc ctacagcagc
     1321 tgctggaacg tgcgctgacc ccactggtgg acgaagtgaa gcagaagggt ctggctcctg
     1381 cctgccccag ttgccagagg ctacacaaga agattctgcc cagtccagta agcccagcgg
     1441 cgcctacact cctctcccca ggagctggag cgccaggcct tggccaaaca cgtcagggca
     1501 gaggccctga gctccaccct tcggctggcc caagacgaag ccgttcgggc caagaaccta
     1561 ctgctgacgg acaagatgaa gccggaggag aaggtggcca ctttggacta tatgcatttg
     1621 aagatgtgtt ccctccacga ccaactcagc cacctgccac ttgaggggtc cacaggggca
     1681 atggggggag gaagcactgg aggggctccc cctaaacgtg ggggtccagg ctctgaacaa
     1741 taaatggcct ctcatgctgg catgaa
//
LOCUS       NM_001127373            4860 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ADNP homeobox 2 (Adnp2), transcript variant 1,
            mRNA.
ACCESSION   NM_001127373 XM_001057780 XM_225732
VERSION     NM_001127373.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001127373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166606.1, SRR26643429.54820.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000018.1  75871377-75871506   c
            131-251             JAXUCZ010000018.1  75862727-75862847   c
            252-341             JAXUCZ010000018.1  75857974-75858063   c
            342-4860            JAXUCZ010000018.1  75846860-75851378   c
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..4860
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox 2"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
     exon            1..130
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="upstream in-frame stop codon"
     exon            131..251
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3554
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox protein 2"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /protein_id="NP_001120845.1"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
                     /translation="MFQIPVQNLDNIRKVRKRVKGILVDIGLDSCKELLKDLKGFDPG
                     EKYFCNTSWGDVSLWEPSGKRAKYRTKPYCCSLCRYSTKVLTSLKNHLHRYHEEEADQ
                     ELMIPCPNCPFASQPKVVGKHFRMFHAPARKVQSYTVNILGEAKTSRSDVISFTCLKC
                     NFSNTLYYSMKKHVLVAHFNYLINSYFGLRTEETGEQPKASDPVSVDKALPFDKYYCK
                     KCSAIASSQDALMYHILTSDAHRDLENKLRSVISEHIKRTGFLKQMHIAPKPVTHIAL
                     PPNSSAPSIAAPPPCFQLALPQNSQSPGTVQSVTVAPGTSGSLTHSPPTTAQSHVALV
                     SSSLPVCQSSLTLQQSAPPPVFLSHSVPLSQPVSTSVLPLTQPLGPVNKSVGTSLLPV
                     NQAMCSVNQAVRPGVLPLPKPMGPINRPVGPGVLPVGPSVNSGVLQATSPGVISVGRA
                     VPSGVLPAGQVTPAGVIPGQTATSGVLPTGQVVQSSVLPVGQTAPSRVLPPGQTVPLR
                     VLPAGQVVPPGLLSPNQTVPSGVVPVNQGVNSGVLQLSQPVTPGVLPVGPPVRPGVLQ
                     LSPSVSTSILPVSQPVRAGTSQNTTFLTSGSILRQLIPTGKQVNGIPTYTLAPVSVTL
                     PVPSAGGLAAVGPPPQVPVQFLPSSSGTQMGSSLPSLPSPQVLVSPAPSVFVQATPPV
                     ADANQALRQAKQWKTCPVCNELFPANVYQVHMEVAHTQSEAKSSEKPEPERLAACAPF
                     LKWMREKTVRCLSCKCLVSQEELMHHLLMHGLGCLFCPCTFHDVRGLVEHSRTKHLGK
                     KRLSMDYSNRGFQLDLDANGNLLFPHLDFITILPREKLGEREVYLAILAGIHSKSLVP
                     VYVKVRPQPEVAPKIPNRQKLTCPFCFGTFMAADAYELHLKERHHVMPTVHTMLRSPA
                     FKCIHCCGVYTGNMTLGAIAVHLLRCRSAPKDSSSDLQAQPDFIESSELLMVNGEVIP
                     ESTFPLKRKLPEGHLGPEEQGDGDEPQLTVDTDASPGSEKGLSAVPLKRQKNESRTEG
                     SGASDDSLQVLALDPSKYGSRSYEEKKQFLRDYFHKRPYPSRKEVELLSSLLWVWKID
                     VASFFGKRRYICMKAIKSHKPSVLLGFDMSELKNVKHRLNFECESENL"
     misc_feature    144..3137
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    144..3137
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    3276..3437
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    3276..3437
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(3282..3293,3297..3299,3348..3350,3366..3368,
                     3405..3407,3411..3416,3423..3428,3432..3440,3444..3449)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(3282..3293,3297..3299,3348..3350,3366..3368,
                     3405..3407,3411..3416,3423..3428,3432..3440,3444..3449)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(3285..3287,3294..3296,3414..3416,3423..3428,
                     3435..3437)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(3285..3287,3294..3296,3414..3416,3423..3428,
                     3435..3437)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            252..341
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     exon            342..4860
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgccatc ttctctttct ggcgcgcggg aggagggacg ggcgcggggc gggggtcccg
       61 ccgcgtaggc ggaggacgcg gcggtgttgc gacggcggcg ggacgcggcg ctcctcgcgc
      121 cccgtggtag gaaaatatca aaaatgtttc aaattcctgt gcagaatctt gacaacatca
      181 gaaaggtgcg gaagagggtg aaaggcatcc ttgtggacat tggacttgac agctgcaagg
      241 agctgctgaa ggatcttaaa ggctttgatc cgggagagaa gtacttttgt aatacatcgt
      301 ggggagatgt ttctctttgg gaaccttctg gaaagagagc gaaatacaga acaaagccct
      361 actgctgtag tctctgcagg tactcaacga aggtgctcac ctccctcaaa aatcacctgc
      421 accgatacca cgaagaggag gctgaccagg agctcatgat cccctgcccc aactgcccgt
      481 ttgcctctca gcccaaggtt gtgggcaagc acttcagaat gttccacgcg cctgcgcgga
      541 aagtccagag ctacacagtg aacatcctgg gtgaggcgaa gacttcaagg agtgatgtga
      601 taagcttcac atgtttaaaa tgtaactttt caaacactct gtactacagc atgaagaagc
      661 atgtgctggt ggcccatttt aattacttaa ttaactccta ctttggattg cgaactgagg
      721 aaacaggaga acaaccgaaa gcaagtgatc cagtttctgt ggataaagcc ctgccatttg
      781 acaagtacta ctgtaaaaaa tgcagcgcca tcgccagtag tcaggatgcc ctgatgtatc
      841 acattctgac atcagatgca catagggact tggagaataa gctgaggtct gttatctcag
      901 agcacatcaa gaggaccggg tttctgaagc aaatgcatat tgctccaaag ccagtgaccc
      961 acatagcttt accgccaaac agcagtgctc cgagcattgc agcccctcct ccttgcttcc
     1021 agcttgcttt gccacagaac agtcaaagtc ccggcactgt gcagtcagtg actgtggccc
     1081 caggcacttc tgggagcctt acacactcac cacctaccac ggcccagtct catgtagctc
     1141 tggtctccag ctctttgcct gtgtgccaga gtagcctcac cctgcagcag tccgctcccc
     1201 cacctgtctt tctctctcac agtgtcccac tgagtcagcc cgtcagtact tctgtgctgc
     1261 ctctcactca gccacttggg cctgtgaata agtctgttgg aacaagcctc ctccctgtga
     1321 accaagccat gtgctccgtg aaccaagctg tccgccctgg agttttaccc ctccctaagc
     1381 ccatggggcc cataaacaga cctgtgggcc ctggtgtctt gcctgtgggt ccctctgtta
     1441 actcaggggt tctccaggct acatctcctg gggtgatttc tgtaggtcga gcagttccat
     1501 caggagtcct tcctgcaggt caggtgaccc ctgctggtgt gatccctggg cagacagcca
     1561 cttccggggt cttacccact ggccaggtgg tccagtcgtc agttctccct gttggccaga
     1621 cagcgccatc tcgagttctc cctcctggcc agacagtgcc cttgagggtt ctccctgcag
     1681 gccaggtggt accgcctggg ctgctttctc caaaccaaac tgtcccctcg ggagttgtcc
     1741 ctgtgaatca aggtgtgaac tctggtgttc ttcagctcag tcagccagta acaccaggag
     1801 tccttcctgt gggcccaccc gtgaggcctg gtgttctgca gctcagtccg tctgtcagca
     1861 ccagcatcct gcccgtgagc cagccggtga gagctggaac gtcccaaaac actactttcc
     1921 ttacttcagg ttctattctc agacagctca ttccaactgg gaaacaggtg aatggaatcc
     1981 ccacctatac gctggcccca gtgtccgtca ctctgccggt gccctccgct ggaggccttg
     2041 cagctgttgg accgccaccc caggtgccag tgcagttcct gccctcaagc tcgggcacac
     2101 agatgggcag ctccttgccc agcctgccct cgccacaggt gctagtgagc cctgccccta
     2161 gcgtgtttgt tcaggctacc ccgcctgtgg cagatgcaaa tcaggcactc agacaggcca
     2221 agcagtggaa aacatgccca gtttgcaacg agctcttccc tgccaacgtc taccaggtcc
     2281 acatggaagt ggctcacacg cagagcgagg ccaagtccag tgagaagcct gagcccgaaa
     2341 ggcttgctgc atgcgcccca tttctgaagt ggatgagaga gaagacagtg cgctgcctct
     2401 cttgtaagtg cctggtctcg caggaggagc tgatgcacca tttgctcatg catggcctgg
     2461 ggtgcctgtt ctgtccatgc acttttcatg atgtccgggg ccttgtggag cacagcagga
     2521 ctaagcacct gggcaagaag agactgtcta tggattacag taacagaggt ttccagctgg
     2581 acttggatgc taatgggaac ctgctgttcc ctcatctcga tttcatcacc atactgccac
     2641 gagagaaact tggagagcga gaagtgtacc tggctatcct tgctggaata cactccaagt
     2701 cgttggtccc tgtgtacgtt aaggtgaggc ctcagcctga ggttgcacca aagataccta
     2761 acagacagaa gctgacctgc ccgttctgtt ttggcacatt catggctgct gatgcctacg
     2821 agctgcatct gaaggagagg caccatgtca tgcccacagt ccatacaatg ctccggtctc
     2881 cggcctttaa gtgcatccac tgttgtgggg tctacactgg aaacatgacc ttaggagcca
     2941 tcgctgtcca tttgctccgt tgtagaagtg ctccaaagga cagcagctca gacctgcaag
     3001 cccagccaga ttttatcgag agcagtgaac tgctgatggt caatggggaa gtgatccccg
     3061 agtccacctt tcctctgaag agaaagctgc cagaaggcca tttagggcca gaagagcagg
     3121 gggacgggga cgagccccag ctcacagtag acaccgatgc gagcccaggt tcagagaaag
     3181 ggctgagtgc tgtgcctttg aagagacaga agaatgagag caggacagag gggtcagggg
     3241 ccagtgatga ctccctgcag gtgttggcgt tagaccccag taagtatgga agtcgttcct
     3301 atgaggaaaa gaaacagttc ctcagagact attttcacaa gagaccatat cctagtcgaa
     3361 aagaagtgga actactgtcc tcgctcttgt gggtgtggaa aatcgacgtg gcctcgttct
     3421 ttgggaaaag gaggtatatc tgcatgaaag caataaaatc ccacaagccc tctgtacttc
     3481 tgggttttga tatgtctgag cttaagaatg tcaaacacag gctgaacttt gagtgtgagt
     3541 cagaaaacct gtaggagagt aagtctgaag tctcctgact tccagccctt cccacctctc
     3601 gctctgttgt aagtgtccga ggcccttcaa ggtgtcccag gtgctcagaa agcctgaaaa
     3661 ggaagcacac actgccacag aggagctgtt ctccgcagtt tgcgttgcgg ctgtctgttt
     3721 tccttctgtc atgtaaatta aatctttggt attccatgca cgccttgttt ccccacgagt
     3781 gtcagtgtca atagcaacaa cctggagtct gcagatactt ggtttttcat tttagagaat
     3841 ttctgcttgt ttgagaaact tgattaatag aaaattgaag cgttgctccc tcttagttcc
     3901 tagctgcagc tagtgacagt gtgtgtttag agaagcaagc actctgatgt gtatgactcc
     3961 ctaaggacat acttttaagc attaacttct gctgattctg tgaccgacgt ttgcttaagg
     4021 ctacaaattt gatttacacc ttttcaagtg tcccctgaca gctatttttt taatatcatt
     4081 attcattaaa aaaatcccag atgttttcca tttattaaaa tatcctgact ctgaggtctg
     4141 gtgtgtagta ataatcaagt gttgctttat aaataaagac tctgtaggaa cagaaatgct
     4201 ttatggtgca cactgtcttt tgctgtgatg acaagtcatt tctccattca aaggtaagac
     4261 atttttagtg cctttagact aaactgaaaa ccctgaggcc cttccttctt ggaactgctt
     4321 gtgaacagtg ggaaggaagg gcccacgata gacattcgtg tctggctctt gatttagaca
     4381 caacctgagg tggaattcgg gtttcgggca taaggcgaca ggcagacgag ctgtgcctgt
     4441 ggttagagta gctggggatg ctgtgtggga gtcaggcctt cagatgaagg gatggtgaag
     4501 cagtgaatgc tcacaatcct gccgatgcca catcttgctt ttccccctcc ctacgcgatc
     4561 ggtaatgtaa agcaccagac ttggtaacga gggccggcca gctctggtcc caatcaccct
     4621 cacccctccg ggtgacgcaa gcaggggttg gccctcagaa cacgagcttg atgaccctgg
     4681 gaagcgctgc agtgttgctg tatggcggtt ttaaaataca cttgcatgtg atcactgaag
     4741 tgttgactcg aggcggttat ctgtgactct tgtaaattca gagcctgttg gaccttattt
     4801 tttttttttt taattttcag agtgtctatt tttgaattaa aatttgttaa accactgaaa
//
LOCUS       NM_001106249            2686 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sialic acid binding Ig-like lectin 5 (Siglec5),
            transcript variant 1, mRNA.
ACCESSION   NM_001106249 XM_001080306 XM_218613
VERSION     NM_001106249.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Tateno,H., Li,H., Schur,M.J., Bovin,N., Crocker,P.R.,
            Wakarchuk,W.W. and Paulson,J.C.
  TITLE     Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F
            reflect roles in cell signaling and innate immunity
  JOURNAL   Mol Cell Biol 27 (16), 5699-5710 (2007)
   PUBMED   17562860
REFERENCE   2  (bases 1 to 2686)
  AUTHORS   Zhang,J.Q., Biedermann,B., Nitschke,L. and Crocker,P.R.
  TITLE     The murine inhibitory receptor mSiglec-E is expressed broadly on
            cells of the innate immune system whereas mSiglec-F is restricted
            to eosinophils
  JOURNAL   Eur J Immunol 34 (4), 1175-1184 (2004)
   PUBMED   15048729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001106249.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.2153.1,
                                           SRR26643284.632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000001.1  102904695-102905022
            329-691             JAXUCZ010000001.1  102905085-102905447
            692-970             JAXUCZ010000001.1  102905601-102905879
            971-1018            JAXUCZ010000001.1  102906048-102906095
            1019-1270           JAXUCZ010000001.1  102908845-102909096
            1271-1573           JAXUCZ010000001.1  102909196-102909498
            1574-1670           JAXUCZ010000001.1  102909776-102909872
            1671-1806           JAXUCZ010000001.1  102910168-102910303
            1807-2686           JAXUCZ010000001.1  102912403-102913282
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2686
                     /gene="Siglec5"
                     /note="sialic acid binding Ig-like lectin 5"
                     /db_xref="GeneID:292843"
                     /db_xref="RGD:1305432"
     exon            1..328
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    247..249
                     /gene="Siglec5"
                     /note="upstream in-frame stop codon"
     CDS             292..1998
                     /gene="Siglec5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 5 isoform 1
                     precursor"
                     /protein_id="NP_001099719.2"
                     /db_xref="GeneID:292843"
                     /db_xref="RGD:1305432"
                     /translation="MLWAQLLPLLWAGSLAVENYELSLTESVTVQEGLCVFVPCQVKY
                     PASGGSVFGYWFQDGANTNLNSPVATNDPHRPVQQETQGRFYLVGGIDTKNCSLDIRD
                     ARKSDTGKYFFRLDGSVKYSFRNRMLSVHVTALTKTPNLQVTSTLVSGTSTRVICSVL
                     WACEQGTPPIFSWMSSALTSLGRRTILSSELNLTPRPQDNGTNLICQVTFPGAGVTVE
                     RTQQLSVTYAPQKLTIRVSWGDGTETKVLQSGASLQIQEGESLRLVCVADSNPSAMLS
                     WKRQTQKNFRLSKGDELQLPRVELEDQGKYICQAKNSLGTQTASVSLSIRSLLQLLAP
                     SCSWDSEGLHCSCSSRAWPAPSLGWRLGEGLLEGNSSNASFTVMSSSAGPWVNSSLSL
                     SVEFSTDHRLSCEAWNDYGVQRATIVLVPGQGVSQDKSETSGGAVQGAIWGAGLMALL
                     AVSFCLIFFIVKFLRKKSALEVAAMEGNHLAKNLVSTINSASMISSNIPLRYPIQDHL
                     NESESQTQKEEPPLATAPDIPKDEPELHYASLSFQGPRPQQPKNTETIKSVYTEIKIH
                     KR"
     sig_peptide     292..339
                     /gene="Siglec5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    349..690
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    349..690
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    397..411
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    397..411
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    445..459
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    445..459
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    577..591
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    577..591
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    619..636
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    619..636
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    655..675
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    655..675
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    706..960
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    706..960
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    748..762
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    748..762
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    799..813
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    856..870
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    856..870
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    898..915
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    898..915
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    943..954
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    943..954
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1045..1266
                     /gene="Siglec5"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    1045..1266
                     /gene="Siglec5"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    1072..1086
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1072..1086
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1111..1134
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1111..1134
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1171..1185
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1171..1185
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1204..1221
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1204..1221
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1249..1260
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1249..1260
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    <1330..1548
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    <1330..1548
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1357..1371
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:319310"
     misc_feature    1357..1371
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:319310"
     misc_feature    1453..1467
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:319310"
     misc_feature    1453..1467
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:319310"
     misc_feature    1492..1509
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:319310"
     misc_feature    1492..1509
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:319310"
     misc_feature    1531..1542
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:319310"
     misc_feature    1531..1542
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:319310"
     exon            329..691
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            692..970
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1018
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1270
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1573
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1670
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1806
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2686
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatgagaaa caaatgcgac agttcaggag cggagggcgg ctcttcctcg ctgactttgg
       61 ctcccatgat gccacacagg aaaagtggaa gtgtttattt tccaagggcc ttgatatcgc
      121 tgataacctg cgggtggaaa gttccttcct tctctgtggt cagtcaccct gcctctcttc
      181 attcctgggc taggtcagta ggacgacttc tcagtcctgt gacattgaag cctatgaccc
      241 tcgaactgac caagttttct gtctctggag cctaggacct ttcactgcgt gatgctgtgg
      301 gcacagctgc tgcccctgct gtgggcaggg tccctggccg tggagaatta tgagctctca
      361 ttgactgaat cagtgacggt gcaggagggt ctgtgcgtct ttgtaccctg ccaagtcaag
      421 taccctgctt ccgggggttc tgtttttggc tactggttcc aggatggggc caacacaaac
      481 ctcaactctc cagtggctac aaatgaccca catcgaccag tacagcagga aactcaaggt
      541 cgtttctatc tcgtgggggg catagatact aaaaattgct ccctggacat cagagacgca
      601 cggaaaagtg acacaggaaa gtacttcttc aggttggatg gaagtgtgaa atacagtttc
      661 cggaatcgga tgctctctgt gcatgtgaca gctctgacta agacccctaa cctccaagtc
      721 acatctaccc tggtgtctgg cacttctacc cgagtgatct gttctgtgct ctgggcctgt
      781 gagcagggga caccccccat cttttcctgg atgtcatctg ccctcacttc cctgggccgc
      841 agaaccatcc tctcctcaga gctgaacctc acacctaggc ctcaggacaa cggcaccaac
      901 ctcatctgtc aggtgacctt ccctggtgct ggtgttactg tggagaggac tcaacagctc
      961 agtgtcacct atgctccaca gaagctgacc atcagggtgt cctggggaga tggcacagaa
     1021 actaaagtcc tgcagagtgg agcatctctg cagatccaag agggtgagtc cctgcgcctg
     1081 gtctgtgtgg cagacagcaa cccctctgcc atgctgagct ggaagcgcca gacccagaag
     1141 aacttccggc tctctaaggg tgatgaactt caactgccac gggtggagtt ggaggaccag
     1201 ggaaaataca tctgccaggc taagaacagt ctgggtactc agacagcctc tgtgagcctc
     1261 agcataagga gccttctaca gctgctggca ccctcctgct cctgggattc tgagggtctg
     1321 cactgcagct gctcctccag agcctggcct gccccgtccc tgggctggcg gctgggggag
     1381 gggctgctgg agggaaacag cagcaatgcc tccttcacag ttatgtccag ctctgcagga
     1441 ccgtgggtca acagctccct gagcctcagt gtggaattca gcactgacca cagactcagc
     1501 tgtgaagctt ggaatgacta tggagttcag agagccacta tcgtgctggt tccaggacaa
     1561 ggagtctcac aggacaaatc agaaaccagt ggaggagcgg ttcagggggc catctgggga
     1621 gctggtctta tggctttgct tgctgtctcc ttctgcctca tcttcttcat agtgaagttc
     1681 ctcaggaaga aatcagcatt ggaagtagca gccatggaag gcaaccacct tgccaagaac
     1741 cttgtctcca ccataaatag tgcaagcatg atttcgtcca acattccatt gagatacccc
     1801 atccaggatc atctgaatga atcagagtca cagacccaga aagaagagcc acctcttgcc
     1861 acagccccag acatcccaaa ggatgagccc gaacttcact atgcctccct ctccttccaa
     1921 ggtccgaggc cccagcagcc aaagaacacg gagaccatca agtctgttta cacagagatc
     1981 aagattcaca agcgctgaag ctccttgccc catgtgtcag tcacagtgct ggctggagtc
     2041 ccagaaaggc atggctgaag atagcatgtg ttaggagcat attctggcat cagtggccct
     2101 cttaaccaaa ggatatgtag tggaaggagg gagttttgga aggagagaag gttacagaga
     2161 ttcctaggtt caaatccata ttcagtgtta ttcccagaga agccaccttt tttctttgtg
     2221 ccccctcttc ctcctctgta aagtggagtc ataatctgag gagtaccaag gagagaatgt
     2281 gtttattgtt gattatattg ctttatgttg cctgagcagt ggggaagaac gttttgtctt
     2341 tattgcataa cttgaatttt acttgtatat ttttaaagaa catatgttag ttcctaaagt
     2401 tattctgttt tgaagtgtga ctgtgttgta gctacctgta tctcagattg gactcattgg
     2461 acattctgca aactcttaaa gatcatacag atatcagccc agactactat acccagtaaa
     2521 attaacaatc atggggcata aagctaatat ataaagatct cccacaaatc aataaaagtg
     2581 acagacaatt caatacaaaa tggtaatatg tgagtggtaa gcaaacatac agaaaggtga
     2641 ccaatcagtg cttgtcaacg aaatataaat aaatacagta caccta
//
LOCUS       NM_001437448            1842 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 6, mRNA.
ACCESSION   NM_001437448 XM_063284130
VERSION     NM_001437448.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284130.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2996.1,
                                           SRR26360181.2953937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-702             JAXUCZ010000001.1  104572249-104572332
            703-989             JAXUCZ010000001.1  104572931-104573217
            990-1184            JAXUCZ010000001.1  104574234-104574428
            1185-1358           JAXUCZ010000001.1  104574810-104574983
            1359-1494           JAXUCZ010000001.1  104576616-104576751
            1495-1662           JAXUCZ010000001.1  104577665-104577832
            1663-1842           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1842
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1740
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 6 is encoded by transcript variant 6; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     6"
                     /protein_id="NP_001424377.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALL
                     EEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEP
                     PRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQE
                     ALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLR
                     SELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQ
                     LLERALTPLVDEVKQKGLAPACPSCQRLHKKILPSPVSPAAPTLLSPGAGAPGLGQTR
                     QGRGPELHPSAGPRRSRSGQEPTADGQDEAGGEGGHFGLYAFEDVFPPRPTQPPAT"
     misc_feature    187..>1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..>1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    688..690
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    802..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    859..861
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    943..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..989
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1184
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1358
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1662
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1842
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaagga gaactgccgc aaggtgaccc gttcagtgga agacgctgaa
      661 atcaaaacca atgtcctgaa gcagaactct gccttgttgg aggagaagct aagatacctc
      721 cagcagcaac tgcaggatga gacgccccgg agacaggagg ccgagttgca ggagctggag
      781 caaaaactag aggctggcct ctcccggcat ggcctaggcc ctactactcc cattcagggc
      841 tgctccggtc ctcctggtag cccggaggaa cccccgcggc cgcgaggcct gccctccaat
      901 ggctggggca tggcaatccg cgcaggggag ggaccctcgc tgagcgagca ggagttgcag
      961 aaggtctcca gcggcctaga ggagctgagg agggaggtgt cctcgctggc agctcggtgg
     1021 catcaggagg agggggcggt gcaggaggcc ctaaggttgc tgggaggcct gggcggccgt
     1081 ctggatggct ttctgggcca atgggagcgg gcgcagcggg aacaagcaca gtccgcacgg
     1141 ggtttgcagg agctgcgagg acgagcagat gagctgtgca ctatggtgga gaggtcagca
     1201 gtgtctgtcg cttcactgag gagcgaactg gaggcactgg gcccagtaaa accgattctg
     1261 gaggagctgg gacggcaact tcaaaactcc cgaaggggac ctgaccatgt cttgaacttg
     1321 gatcgtcctg cccaaggtcc ctgtcctcga tgtgccagcc aggggcagca gttatccacg
     1381 gagtccctac agcagctgct ggaacgtgcg ctgaccccac tggtggacga agtgaagcag
     1441 aagggtctgg ctcctgcctg ccccagttgc cagaggctac acaagaagat tctgcccagt
     1501 ccagtaagcc cagcggcgcc tacactcctc tccccaggag ctggagcgcc aggccttggc
     1561 caaacacgtc agggcagagg ccctgagctc cacccttcgg ctggcccaag acgaagccgt
     1621 tcgggccaag aacctactgc tgacggacaa gatgaagccg gaggagaagg tggccacttt
     1681 ggactatatg catttgaaga tgtgttccct ccacgaccaa ctcagccacc tgccacttga
     1741 ggggtccaca ggggcaatgg ggggaggaag cactggaggg gctcccccta aacgtggggg
     1801 tccaggctct gaacaataaa tggcctctca tgctggcatg aa
//
LOCUS       NM_001437483            2821 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 9, mRNA.
ACCESSION   NM_001437483 XM_063277309
VERSION     NM_001437483.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 2821)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 2821)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277309.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77364.1,
                                           SRR26360181.1691712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000018.1  48404972-48405181
            211-313             JAXUCZ010000018.1  48472546-48472648
            314-386             JAXUCZ010000018.1  48485845-48485917
            387-566             JAXUCZ010000018.1  48507187-48507366
            567-680             JAXUCZ010000018.1  48514668-48514781
            681-806             JAXUCZ010000018.1  48523111-48523236
            807-976             JAXUCZ010000018.1  48526537-48526706
            977-1069            JAXUCZ010000018.1  48532075-48532167
            1070-2123           JAXUCZ010000018.1  48532658-48533711
            2124-2194           JAXUCZ010000018.1  48534878-48534948
            2195-2821           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2821
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..210
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..313
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    255..257
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             285..2279
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 3 is encoded by transcript variant 9;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 3"
                     /protein_id="NP_001424412.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MKSTLVMTFLIQSHLSRPSQHCAEDVTHRTKTDQPHLAADNLDK
                     IHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAIKNGQLECVR
                     WMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQEGNSA
                     VHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYLVVVETCMSL
                     ASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSPASRKSQWKI
                     LDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKEISENVCTQE
                     KLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKNTPVK
                     RVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLDGHSPSPTSE
                     SSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSPSSKRRTSQN
                     SKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGTFRSIMESLS
                     GNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAMYSSCIHLPS
                     NALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     misc_feature    <390..911
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <390..911
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(429..431,435..437,447..452,459..467,471..476,
                     486..488,501..503,528..530,534..536,540..542,657..662,
                     669..677,681..686,696..698,717..719,744..746,750..752,
                     756..758,768..773,780..788,792..797,807..809,816..818,
                     843..845)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(429..431,435..437,447..452,459..467,471..476,
                     486..488,501..503,528..530,534..536,540..542,657..662,
                     669..677,681..686,696..698,717..719,744..746,750..752,
                     756..758,768..773,780..788,792..797,807..809,816..818,
                     843..845)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    429..530
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    429..530
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    534..746
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    534..746
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    750..845
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    750..845
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    918..1049
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    918..1049
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    <1665..>2135
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <1665..>2135
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            314..386
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..566
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..680
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..806
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..976
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1069
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..2123
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2194
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2821
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtcgcg tccctgatct caacgtcccg ctgccccggg tgtccccgcc cgcgcgcgcc
       61 cgttgggggg cccggggtgc ggcgccggcc gccgggccgc attgtgacgt agcggggccg
      121 cggcagcgcc tccgccgccc gccggggtct cctgcgcccg ccgctctcgc cgtctgtccg
      181 tccatccctc ccgccgccct tcccgctccg gatattataa atattcgacc ttactcaaaa
      241 tgtacaaaga agaataatgg aagcccctga atatcttgat ctggatgaaa tcgactttag
      301 tgatgacatt tcttattcag tcacatctct caagaccatc ccagcactgt gcagaagatg
      361 tgactcacag aacgaagaca gaccagccac acctagctgc agataatctg gacaaaattc
      421 acgacgagaa cggaaacaat ctgttacacg ttgctgcatc aaagggccat gcggaatgtc
      481 tgcagcacct cacgtcgctg atgggcgaag actgtctgaa tgaacggaac gcagagcaac
      541 tgactccagc gggcctggcc atcaagaatg gtcagctgga gtgtgtacgc tggatggtga
      601 gtgagacgga agccattgcg gaactgagtt gttccaagga tttcccaagc ctaattcatt
      661 acgcaggctg ctatgggcag gaaaagattc ttctgtggct tcttcagttc atgcaagaac
      721 aaggcatctc attggatgaa gtagatcagg aaggcaacag tgctgttcat gtcgcttcac
      781 aacatggcta ccttggatgc atacagaccc tggtggagta tggagcaaat gttacgatgc
      841 agaaccacgc tggggaaaag ccctcccaga gtgccgagcg gcacggccac accctatgtt
      901 cccggtacct cgtggtggta gagacctgta tgtcactggc ctcacaagtg gtaaagttga
      961 ccaagcagct aaaggagcag acagtggagc gcgtcacact gcagagtcaa ctccaacaac
     1021 ttctggaagc ccagaaatca gagggcaagt ccctcccatc ttcacccagt tcaccctcct
     1081 caccagcttc tagaaagtcc cagtggaaaa ttctagatgc agatgacgag tctacaggca
     1141 aaagcaaact gggaacccag gagggaatac aagtccttgg aaacttatcc agcagggcta
     1201 ggaccaaagg aaaagacgaa gactctgata aaatcctacg tcagttattg gggaaagaaa
     1261 tatcagagaa tgtctgcacc caggaaaagc tgtcattgga attccaggat gctcaggtat
     1321 cctctaggaa ttcgaaaaaa atacctctag agaagaggga actgaagcta gctagactgc
     1381 ggcagctgat gcagagatct ttgagtgaat ctgacacgga ttcaaacaac tctgaggacc
     1441 ccaaaaatac tcctgtgaaa agagtggaca gacctagacc acagcccatt gtggaaagtg
     1501 tggagaatat ggacagtgca gaaagcttac acctgatgat aaagaaacac tctgtggcat
     1561 caggacgcag gtttcctttt ggtatgaagg cctccaaatc cctggatggg cacagcccat
     1621 ctcccacttc agagagcagt gaaccagatt tggactccca ttgcccgagc ctgggaatga
     1681 ctcctccaac ccaaccttct acagaagcca ctcagtgcag tcctgacagt gccactgccc
     1741 agaaagttgc tacaagcccc aagagtgccc tcaagtctcc atcatccaag cgccggacat
     1801 cccaaaactc aaaactgaga gtgacctttg aggagcctgt tgtgcaaatg gagcaaacta
     1861 gccttgaact aaatggagaa aaagacaaag agaggggcag ggccccccag aggactagtg
     1921 agtcaggaga acaaatgaaa aggccttttg gaaccttccg atccatcatg gagagtttaa
     1981 gtggtaatca gaacaacaat aataactacc agccagccag ccagctgaag acctgcacac
     2041 tacccttgac gtcacttgga aggaagacag cagatgccaa gggaaaccct gtgagccctg
     2101 ctagcaaagg aaagaataag gcagcgatgt acagcagctg cattcatctt ccctctaatg
     2161 cgctggtcga agagcatctg cgtgattatg cacggcttaa tgacatcaaa agaaacacga
     2221 agaaaactta caacgtaaag cacattgctg aaccagagcc aaaggaactc ttcttataaa
     2281 ttactcttag tatgagtctc acacatgccc tctggccacc attgggagtt aatggactgt
     2341 ggcaatcaga ccatgagaac aacacctcac cagcgagcag aatatctgga tgccttaaat
     2401 ttataatatg agacttgtta taagatacat tttggaccat atctgtacat agaacttgtt
     2461 tgatttcttt tttaatatgc tgtttgaaaa catgatcggg caatgtatgc attgacacat
     2521 tggacatttg attgagtcga ccttcttgaa gcacatccac cagcacctga cacgactagt
     2581 gtttttgtga attgcatgag gatttgctga tgttgattag atgttcacct tctttgtaac
     2641 aagggcagct gtggctcagc tcagtgaggc caggtcactg gttttatttt ctgtccagtg
     2701 tgtttttctg tcatttctac ttttttaata aagaaaatta aacatttgta acagcagact
     2761 ctgggcgtgg ggggcagggc atctactttc taataaatct gtgaagctct gatttctaaa
     2821 a
//
LOCUS       NM_001437513            3392 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 1 receptor (Csf1r),
            transcript variant 2, mRNA.
ACCESSION   NM_001437513 XM_039096836
VERSION     NM_001437513.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3392)
  AUTHORS   Hume,D.A., Teakle,N., Keshvari,S. and Irvine,K.M.
  TITLE     Macrophage deficiency in CSF1R-knockout rat embryos does not
            compromise placental or embryo development
  JOURNAL   J Leukoc Biol 114 (5), 421-433 (2023)
   PUBMED   37167456
  REMARK    GeneRIF: Macrophage deficiency in CSF1R-knockout rat embryos does
            not compromise placental or embryo development.
REFERENCE   2  (bases 1 to 3392)
  AUTHORS   Sehgal,A., Carter-Cusack,D., Keshvari,S., Patkar,O., Huang,S.,
            Summers,K.M., Hume,D.A. and Irvine,K.M.
  TITLE     Intraperitoneal transfer of wild-type bone marrow repopulates
            tissue macrophages in the Csf1r knockout rat without contributing
            to monocytopoiesis
  JOURNAL   Eur J Immunol 53 (8), e2250312 (2023)
   PUBMED   37059596
  REMARK    GeneRIF: Intraperitoneal transfer of wild-type bone marrow
            repopulates tissue macrophages in the Csf1r knockout rat without
            contributing to monocytopoiesis.
REFERENCE   3  (bases 1 to 3392)
  AUTHORS   Keshvari,S., Caruso,M., Teakle,N., Batoon,L., Sehgal,A.,
            Patkar,O.L., Ferrari-Cestari,M., Snell,C.E., Chen,C., Stevenson,A.,
            Davis,F.M., Bush,S.J., Pridans,C., Summers,K.M., Pettit,A.R.,
            Irvine,K.M. and Hume,D.A.
  TITLE     CSF1R-dependent macrophages control postnatal somatic growth and
            organ maturation
  JOURNAL   PLoS Genet 17 (6), e1009605 (2021)
   PUBMED   34081701
  REMARK    GeneRIF: CSF1R-dependent macrophages control postnatal somatic
            growth and organ maturation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3392)
  AUTHORS   Patkar,O.L., Caruso,M., Teakle,N., Keshvari,S., Bush,S.J.,
            Pridans,C., Belmer,A., Summers,K.M., Irvine,K.M. and Hume,D.A.
  TITLE     Analysis of homozygous and heterozygous Csf1r knockout in the rat
            as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations
  JOURNAL   Neurobiol Dis 151, 105268 (2021)
   PUBMED   33450391
  REMARK    GeneRIF: Analysis of homozygous and heterozygous Csf1r knockout in
            the rat as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations.
REFERENCE   5  (bases 1 to 3392)
  AUTHORS   Sharon,A., Jankowski,M.M., Shmoel,N., Erez,H. and Spira,M.E.
  TITLE     Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat
            Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and
            Its Implications
  JOURNAL   Front Neurosci 15, 646914 (2021)
   PUBMED   33841088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3392)
  AUTHORS   Storga,D., Pecina-Slaus,N., Pavelic,J., Pavelic,Z.P. and Pavelic,K.
  TITLE     c-fms is present in primary tumours as well as in their metastases
            in bone marrow
  JOURNAL   Int J Exp Pathol 73 (4), 527-533 (1992)
   PUBMED   1390197
REFERENCE   7  (bases 1 to 3392)
  AUTHORS   Borycki,A.G., Guillier,M., Leibovitch,M.P. and Leibovitch,S.A.
  TITLE     Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence
            analysis and regulation during myogenesis
  JOURNAL   Growth Factors 6 (3), 209-218 (1992)
   PUBMED   1389227
REFERENCE   8  (bases 1 to 3392)
  AUTHORS   Claycomb,W.C. and Lanson,N.A. Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   9  (bases 1 to 3392)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 3392)
  AUTHORS   Sherr,C.J., Rettenmier,C.W., Sacca,R., Roussel,M.F., Look,A.T. and
            Stanley,E.R.
  TITLE     The c-fms proto-oncogene product is related to the receptor for the
            mononuclear phagocyte growth factor, CSF-1
  JOURNAL   Cell 41 (3), 665-676 (1985)
   PUBMED   2408759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096836.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74237.1,
                                           SRR26643299.62937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000018.1  56834271-56834427
            158-415             JAXUCZ010000018.1  56838153-56838410
            416-552             JAXUCZ010000018.1  56840670-56840806
            553-712             JAXUCZ010000018.1  56841407-56841566
            713-899             JAXUCZ010000018.1  56844188-56844374
            900-1015            JAXUCZ010000018.1  56846766-56846881
            1016-1136           JAXUCZ010000018.1  56847022-56847142
            1137-1327           JAXUCZ010000018.1  56847259-56847449
            1328-1443           JAXUCZ010000018.1  56848724-56848839
            1444-1570           JAXUCZ010000018.1  56853763-56853889
            1571-1675           JAXUCZ010000018.1  56854006-56854110
            1676-1786           JAXUCZ010000018.1  56854387-56854497
            1787-1949           JAXUCZ010000018.1  56855134-56855296
            1950-2038           JAXUCZ010000018.1  56857334-56857422
            2039-2136           JAXUCZ010000018.1  56857539-56857636
            2137-2259           JAXUCZ010000018.1  56858446-56858568
            2260-2371           JAXUCZ010000018.1  56858645-56858756
            2372-2471           JAXUCZ010000018.1  56859399-56859498
            2472-2580           JAXUCZ010000018.1  56859804-56859912
            2581-3392           JAXUCZ010000018.1  56859996-56860807
FEATURES             Location/Qualifiers
     source          1..3392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3392
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="colony stimulating factor 1 receptor"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
     exon            1..157
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="upstream in-frame stop codon"
     CDS             109..2760
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; macrophage colony-stimulating factor 1
                     receptor; fms proto-oncogene; proto-oncogene fms;
                     proto-oncogene c-Fms; CSF-1 receptor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 receptor
                     isoform 2 precursor"
                     /protein_id="NP_001424442.1"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
                     /translation="MELGAPLVLLLATAWHGQGAPVIEPSGPELVVEPGATVTLRCVS
                     NGSVEWDGPISPYWTLDSESPGSILITKNATFKNTGTYRCTELEDPMRGSTAIHLYVK
                     AHPGPPHIILEPTKLVRIRGEAAQIVCSATHSEVEFNVILKRGDTKLEIPINSDFQDN
                     AYKKVLTLNLNAVDFQDAGIYSCVANNAAGSNTATMNFQVVESAYLNLTSEQSLLQEV
                     SVGENLDLTVIADAYPGLQRYNWTYLGPFFEDPHNLEFRTQWTTYSYSFKLHLNRVKP
                     LEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTWIPVNGSDVLLCDVSGYPQPNVTW
                     MECRGHTDRCDEAQASQVWDDTQPEVLSQKPFHRVILQSQLPIGTLKHNMTYVCRAHN
                     NVGNSSQFFRAISLGQSKQLPDEYLFTPVVVACISVMSLLVLLLLLLLYKYKQKPKYQ
                     VRWKIIESYEGNNYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLG
                     KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVIT
                     EYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSSYKNIHLEKKYVRRDSGFSSQGVD
                     TYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDV
                     AARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSD
                     VWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDL
                     EPTKRPTFQQICFLLQEQARLERREQDYANLPSSSSSSSSSSDSGGGSGGSSSEPEEE
                     SSSEHLACCEPGDIAQPLLQPNNYQFC"
     sig_peptide     109..165
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    190..411
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    190..411
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    220..234
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409410"
     misc_feature    220..234
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409410"
     misc_feature    271..282
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409410"
     misc_feature    271..282
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409410"
     misc_feature    304..318
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409410"
     misc_feature    304..318
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409410"
     misc_feature    370..381
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409410"
     misc_feature    370..381
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409410"
     misc_feature    430..708
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    430..708
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    481..495
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409530"
     misc_feature    481..495
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409530"
     misc_feature    523..537
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409530"
     misc_feature    523..537
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409530"
     misc_feature    598..612
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409530"
     misc_feature    598..612
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409530"
     misc_feature    646..663
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409530"
     misc_feature    646..663
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409530"
     misc_feature    685..696
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409530"
     misc_feature    685..696
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409530"
     misc_feature    718..1017
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    718..1017
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    778..792
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409364"
     misc_feature    778..792
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409364"
     misc_feature    820..834
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409364"
     misc_feature    820..834
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409364"
     misc_feature    907..921
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409364"
     misc_feature    907..921
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409364"
     misc_feature    949..966
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409364"
     misc_feature    949..966
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409364"
     misc_feature    988..999
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409364"
     misc_feature    988..999
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409364"
     misc_feature    1018..1284
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    1018..1284
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    1444..2562
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Colony-Stimulating Factor-1 Receptor; Region: PTKc_CSF-1R;
                     cd05106"
                     /db_xref="CDD:133237"
     misc_feature    1444..2562
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Colony-Stimulating Factor-1 Receptor; Region: PTKc_CSF-1R;
                     cd05106"
                     /db_xref="CDD:133237"
     misc_feature    order(1579..1584,1588..1599,1603..1605,1657..1659,
                     1663..1665,1807..1809,1813..1815,1825..1827,2149..2151,
                     2161..2166,2170..2172,2203..2205,2257..2271,2296..2298,
                     2401..2403)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="active site"
                     /db_xref="CDD:133237"
     misc_feature    order(1579..1584,1588..1599,1603..1605,1657..1659,
                     1663..1665,1807..1809,1813..1815,1825..1827,2149..2151,
                     2161..2166,2170..2172,2203..2205,2257..2271,2296..2298,
                     2401..2403)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="active site"
                     /db_xref="CDD:133237"
     misc_feature    order(1579..1584,1588..1599,1603..1605,1657..1659,
                     1663..1665,1807..1809,1813..1815,1825..1827,2161..2166,
                     2170..2172,2203..2205)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(1579..1584,1588..1599,1603..1605,1657..1659,
                     1663..1665,1807..1809,1813..1815,1825..1827,2161..2166,
                     2170..2172,2203..2205)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(2149..2151,2161..2163,2257..2271,2296..2298,
                     2401..2403)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(2149..2151,2161..2163,2257..2271,2296..2298,
                     2401..2403)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    2200..2277
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133237"
     misc_feature    2200..2277
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133237"
     exon            158..415
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            416..552
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            553..712
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            713..899
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1015
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1136
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1327
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1443
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1570
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1675
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1786
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1949
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2038
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2136
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2259
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2371
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2471
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2580
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..3392
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaagaac gtgttcctct gttcccatcc ctacagagtt agcagctggg agccctgtgc
       61 ccagccgact ttccaacctg catcgtccca cgctaacccc tggaggctat ggagctgggg
      121 gctcctctgg tcctgctgct ggccacagct tggcatggtc aaggggcccc tgtcatcgag
      181 cctagtggcc cagagctggt tgtagagcca ggtgcaacag tgaccctgcg atgtgtgagc
      241 aatggcagtg tggaatggga tggccccatc tctccctact ggaccttgga ctctgaatct
      301 cctggaagca tcctgatcac aaaaaacgcc accttcaaaa acactgggac ctaccgttgt
      361 actgagcttg aagaccctat gcggggcagt accgccatcc acttgtacgt caaagcccac
      421 ccagggcccc cacacatcat attggaacct actaagctgg tgaggattcg aggggaggct
      481 gcccagatcg tgtgctcggc cactcactca gaagttgaat tcaacgttat cctcaaacgt
      541 ggagacacca agttggaaat ccccataaac agtgacttcc aagacaacgc ttataaaaag
      601 gtcctgactc ttaacctcaa tgctgtggac ttccaagatg ctggcatata ttcctgtgtg
      661 gccaacaacg cagctggctc gaacacggcc accatgaact tccaggtggt ggagagtgcc
      721 tacttaaact tgacctctga gcagagcctc ttgcaggagg tgtctgtggg tgagaacctc
      781 gacctcacag tcattgcaga tgcctaccct ggcctacagc gttacaactg gacctaccta
      841 gggccgttct ttgaagaccc acacaatctt gagtttagaa cccaatggac cacatacagc
      901 tactcattca aactccacct gaaccgtgta aagcccttgg aggccggccg ctactcctta
      961 atggcacaaa acaaggcagg ctggaataat ctgacctttg agctcaccct gcgatacccc
     1021 ccagaagtca gtgttacatg gatacctgtg aacggctctg atgtcctgct ctgtgatgtc
     1081 tctgggtatc ctcagcccaa cgtgacatgg atggagtgca ggggccacac cgataggtgt
     1141 gatgaggccc aggcctcgca ggtttgggat gacacacaac ctgaagtcct gagtcagaag
     1201 cccttccaca gagtgatcct tcagagccag ctgcccattg ggaccctaaa gcacaacatg
     1261 acttatgttt gcagagccca caacaatgtg ggtaacagct cccagttctt cagggccatc
     1321 tccctaggac aaagcaagca gctccctgat gagtacctgt tcactccagt ggtggtggcc
     1381 tgtatatctg tcatgtctct gctggtacta ctgctgctgc tgctcttgta caagtacaag
     1441 cagaagccga aatatcaggt gcgctggaag atcattgaga gctacgaggg caacaactac
     1501 accttcatcg accctaccca gttgccctac aatgagaagt gggagtttcc ccggaacaac
     1561 ctgcaatttg gtaagactct cggagctggt gcctttggga aggtggtgga ggccacagcc
     1621 tttggtctgg gcaaagaaga tgcagtgctg aaggtggctg tgaagatgct caagtccacg
     1681 gctcatgccg atgagaagga ggccctaatg tcagaactga agatcatgag tcacctggga
     1741 cagcatgaga acattgtcaa cctcttggga gcctgtactc atggagggcc tgtcctggtc
     1801 atcaccgaat actgctgcta cggagacctt ctcaacttcc ttcgaaggaa ggccgaggct
     1861 atgctgggac ccagcctgag tcctggtcag gaccccgagg gggactccag ctacaagaac
     1921 atccacctgg agaagaaata tgtgcgcagg gacagtggct tctccagtca gggcgtagat
     1981 acctatgtgg agatgaggcc tgtttcgact tcctcaaatg actccttctt taagcaagat
     2041 ctggacaaag aggccagccg gccgctggag ctctgggacc tgcttcactt ctctagccaa
     2101 gtggctcagg gcatggcttt ccttgcttct aaaaattgca tccatcgtga tgtagctgct
     2161 cgaaatgtgc tgttgaccag cggacatgtg gccaagattg gggactttgg gctggctagg
     2221 gacatcatga atgactctaa ctatgttgtc aagggcaatg cccgcctgcc tgtaaagtgg
     2281 atggccccag agagcatctt cgactgcgtc tacacagttc agagtgatgt gtggtcctac
     2341 ggcatcctcc tctgggagat tttctcactt ggtctgaacc cctacccagg catcttagtg
     2401 aacaacaagt tctacaaact ggtgaaggat ggataccaaa tggcccagcc tgtatttgca
     2461 ccggagaaca tatacagcat catgcagtcc tgctgggacc tggagcctac caaaagacct
     2521 accttccagc agatctgctt cctcctccag gaacaggccc gactggagag gagagagcag
     2581 gactatgcta acctgccaag cagcagcagc agcagtagca gcagcagtga cagtggtggt
     2641 ggcagtggtg gtagcagcag tgagcctgaa gaggagagct ccagtgagca cctggcctgc
     2701 tgtgagccag gggacatcgc ccagcccctg ctgcagccta acaactacca gttctgctga
     2761 agcgggacag cagagtcctg ctgccctcca cgtcccagct cgacctcctc catggatggg
     2821 cgacatgggg agagcatatg aacttcgtcc tcagctcggc ccagctctga cgcttctgaa
     2881 catgaggggt tcccagagcc tgggccatca ctgccagtgg ggttctcaca gtgctagcct
     2941 ctatttacta caccaactgg tgaacccata cttcactttc ttcatcctgt tcccacttga
     3001 aaaaactgtc cccaactctc gtttcaatgg aaagactgat ttgtgtctca aaaagacagg
     3061 tctcaggttg taggtgagca gaagcttgcc tccctgacag aggctcagac tgcaggcttc
     3121 ttggggcagg cggcccttcc caagctcaca gactggtcgc cactcttacc ttctctttat
     3181 ctacagtccc gtctcatcct ggatcttgta cactaggagc ccagtggcag ctgagagcca
     3241 gggatgcttt acttagtgcc ctgcattcta ggctggcagg catgggacct tggtgcaagg
     3301 ctgacaacgc caagcaaata ctgcgtgctc ctctccaaac tgactcgtcc tcattaacag
     3361 tcaacattaa actaacagca ttaacacagc ca
//
LOCUS       NM_001437475            3619 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 5, mRNA.
ACCESSION   NM_001437475 XM_039096790
VERSION     NM_001437475.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3619)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3619)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3619)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3619)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3619)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3619)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3619)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096790.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000018.1  48404972-48405181
            211-313             JAXUCZ010000018.1  48472546-48472648
            314-386             JAXUCZ010000018.1  48485845-48485917
            387-1255            JAXUCZ010000018.1  48504584-48505452
            1256-1435           JAXUCZ010000018.1  48507187-48507366
            1436-1549           JAXUCZ010000018.1  48514668-48514781
            1550-1675           JAXUCZ010000018.1  48523111-48523236
            1676-1845           JAXUCZ010000018.1  48526537-48526706
            1846-1938           JAXUCZ010000018.1  48532075-48532167
            1939-2992           JAXUCZ010000018.1  48532658-48533711
            2993-3619           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3619
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..210
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..313
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    218..220
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             257..2998
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 2 is encoded by transcript variant 5;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 2"
                     /protein_id="NP_001424404.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAA"
     misc_feature    <1217..1780
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1217..1780
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1298..1300,1304..1306,1316..1321,1328..1336,
                     1340..1345,1355..1357,1370..1372,1397..1399,1403..1405,
                     1409..1411,1526..1531,1538..1546,1550..1555,1565..1567,
                     1586..1588,1613..1615,1619..1621,1625..1627,1637..1642,
                     1649..1657,1661..1666,1676..1678,1685..1687,1712..1714)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1298..1300,1304..1306,1316..1321,1328..1336,
                     1340..1345,1355..1357,1370..1372,1397..1399,1403..1405,
                     1409..1411,1526..1531,1538..1546,1550..1555,1565..1567,
                     1586..1588,1613..1615,1619..1621,1625..1627,1637..1642,
                     1649..1657,1661..1666,1676..1678,1685..1687,1712..1714)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1298..1399
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1298..1399
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1403..1615
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1403..1615
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1619..1714
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1619..1714
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1787..1918
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1787..1918
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            314..386
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1255
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1435
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1549
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1675
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1845
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1938
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2992
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3619
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtcgcg tccctgatct caacgtcccg ctgccccggg tgtccccgcc cgcgcgcgcc
       61 cgttgggggg cccggggtgc ggcgccggcc gccgggccgc attgtgacgt agcggggccg
      121 cggcagcgcc tccgccgccc gccggggtct cctgcgcccg ccgctctcgc cgtctgtccg
      181 tccatccctc ccgccgccct tcccgctccg gatattataa atattcgacc ttactcaaaa
      241 tgtacaaaga agaataatgg aagcccctga atatcttgat ctggatgaaa tcgactttag
      301 tgatgacatt tcttattcag tcacatctct caagaccatc ccagcactgt gcagaagatg
      361 tgactcacag aacgaagaca gaccagtttc tagctctagc tggaattgtg gtgtctcaac
      421 tctcattaca aacccgcaaa agcccactgg aatcgctgat gtatacagta agttccgccc
      481 ggtgaagcga gtttctccac tgaaacatca gccagagact ctggagagca atgaaagtga
      541 cgaccagaag aacaatacag tggaatacca gaaagggggg gagactgacc agggccccca
      601 gcctgaggag ctcagccctg aagatggagt cggaggcttg ccaggcaagg gctcagagcc
      661 cagccaggca ctgggtgagc tggagcacta tgacctcgac atggatgaga ttctggatgt
      721 gccttacatt aaatccagtc aacagctggc cccgctcacc aaggtgactt cagaaaaaag
      781 gattttgggt ttatgcacaa ctgtcaatgg cctctctgcc aaaacctgcc ctattgtaag
      841 cgctgagacc tccacaccca acatggctcc attgtgtgtt ctttctcctg tgaaaagccc
      901 tcacttacgg aaagtaccca gtgtcctccg ggaccagcac aagctccctg cggaagaatc
      961 ggagaactca cccgctcctg gtaaatgcgg ccctgcattt gaatcagaaa accacagtaa
     1021 ggacttctta aacaaggtct ttagtgatcc ccatagtcgg aaagctgaga agtctgggcc
     1081 agactgcaag ctcaggccct tccgcctgca gacctcggca gcaggagcca aaccagagga
     1141 gcaggtcaac ggcgtgagct gggccagtgc ccaaggcgca gaagaaagga ctgagtacct
     1201 gcagaaagta agaagcatac tgaacattgt gaacgaaggg cagatatcgc tcttgccaca
     1261 cctagctgca gataatctgg acaaaattca cgacgagaac ggaaacaatc tgttacacgt
     1321 tgctgcatca aagggccatg cggaatgtct gcagcacctc acgtcgctga tgggcgaaga
     1381 ctgtctgaat gaacggaacg cagagcaact gactccagcg ggcctggcca tcaagaatgg
     1441 tcagctggag tgtgtacgct ggatggtgag tgagacggaa gccattgcgg aactgagttg
     1501 ttccaaggat ttcccaagcc taattcatta cgcaggctgc tatgggcagg aaaagattct
     1561 tctgtggctt cttcagttca tgcaagaaca aggcatctca ttggatgaag tagatcagga
     1621 aggcaacagt gctgttcatg tcgcttcaca acatggctac cttggatgca tacagaccct
     1681 ggtggagtat ggagcaaatg ttacgatgca gaaccacgct ggggaaaagc cctcccagag
     1741 tgccgagcgg cacggccaca ccctatgttc ccggtacctc gtggtggtag agacctgtat
     1801 gtcactggcc tcacaagtgg taaagttgac caagcagcta aaggagcaga cagtggagcg
     1861 cgtcacactg cagagtcaac tccaacaact tctggaagcc cagaaatcag agggcaagtc
     1921 cctcccatct tcacccagtt caccctcctc accagcttct agaaagtccc agtggaaaat
     1981 tctagatgca gatgacgagt ctacaggcaa aagcaaactg ggaacccagg agggaataca
     2041 agtccttgga aacttatcca gcagggctag gaccaaagga aaagacgaag actctgataa
     2101 aatcctacgt cagttattgg ggaaagaaat atcagagaat gtctgcaccc aggaaaagct
     2161 gtcattggaa ttccaggatg ctcaggtatc ctctaggaat tcgaaaaaaa tacctctaga
     2221 gaagagggaa ctgaagctag ctagactgcg gcagctgatg cagagatctt tgagtgaatc
     2281 tgacacggat tcaaacaact ctgaggaccc caaaaatact cctgtgaaaa gagtggacag
     2341 acctagacca cagcccattg tggaaagtgt ggagaatatg gacagtgcag aaagcttaca
     2401 cctgatgata aagaaacact ctgtggcatc aggacgcagg tttccttttg gtatgaaggc
     2461 ctccaaatcc ctggatgggc acagcccatc tcccacttca gagagcagtg aaccagattt
     2521 ggactcccat tgcccgagcc tgggaatgac tcctccaacc caaccttcta cagaagccac
     2581 tcagtgcagt cctgacagtg ccactgccca gaaagttgct acaagcccca agagtgccct
     2641 caagtctcca tcatccaagc gccggacatc ccaaaactca aaactgagag tgacctttga
     2701 ggagcctgtt gtgcaaatgg agcaaactag ccttgaacta aatggagaaa aagacaaaga
     2761 gaggggcagg gccccccaga ggactagtga gtcaggagaa caaatgaaaa ggccttttgg
     2821 aaccttccga tccatcatgg agagtttaag tggtaatcag aacaacaata ataactacca
     2881 gccagccagc cagctgaaga cctgcacact acccttgacg tcacttggaa ggaagacagc
     2941 agatgccaag ggaaaccctg tgagccctgc tagcaaagga aagaataagg cagcttaatg
     3001 acatcaaaag aaacacgaag aaaacttaca acgtaaagca cattgctgaa ccagagccaa
     3061 aggaactctt cttataaatt actcttagta tgagtctcac acatgccctc tggccaccat
     3121 tgggagttaa tggactgtgg caatcagacc atgagaacaa cacctcacca gcgagcagaa
     3181 tatctggatg ccttaaattt ataatatgag acttgttata agatacattt tggaccatat
     3241 ctgtacatag aacttgtttg atttcttttt taatatgctg tttgaaaaca tgatcgggca
     3301 atgtatgcat tgacacattg gacatttgat tgagtcgacc ttcttgaagc acatccacca
     3361 gcacctgaca cgactagtgt ttttgtgaat tgcatgagga tttgctgatg ttgattagat
     3421 gttcaccttc tttgtaacaa gggcagctgt ggctcagctc agtgaggcca ggtcactggt
     3481 tttattttct gtccagtgtg tttttctgtc atttctactt ttttaataaa gaaaattaaa
     3541 catttgtaac agcagactct gggcgtgggg ggcagggcat ctactttcta ataaatctgt
     3601 gaagctctga tttctaaaa
//
LOCUS       NM_001437493            7091 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001437493 XM_063284358
VERSION     NM_001437493.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7091)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7091)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7091)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7091)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 7091)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 7091)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 7091)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 7091)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 7091)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 7091)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.2200.1,
                                           SRR26643287.1278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-3436           JAXUCZ010000001.1  128279474-128279713 c
            3437-4306           JAXUCZ010000001.1  128277918-128278787 c
            4307-4404           JAXUCZ010000001.1  128277712-128277809 c
            4405-4632           JAXUCZ010000001.1  128276273-128276500 c
            4633-4799           JAXUCZ010000001.1  128271583-128271749 c
            4800-5274           JAXUCZ010000001.1  128266965-128267439 c
            5275-5492           JAXUCZ010000001.1  128265159-128265376 c
            5493-5597           JAXUCZ010000001.1  128263816-128263920 c
            5598-7091           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..7091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..7091
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5692
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 2 is encoded by transcript variant 2; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 2"
                     /protein_id="NP_001424422.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQAD
                     CLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQR
                     LDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYE
                     DQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYE
                     QLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPP
                     GFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQS
                     VLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDK
                     TLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGH
                     HSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQP
                     VPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQT
                     FYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPS
                     ETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKA
                     VPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEI
                     YFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGDPKT
                     WQNKCLPGDPNYLVGANCVSVLIDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2906..3256
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3500..3559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3644..3646
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3707..5188
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3848..3850
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3881..4543
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Actin-binding region (ABR).
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    3923..3925
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4490..4492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4526..4528
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4664..4666
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5057..5059
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5273..5275
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5318..5659
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     misc_feature    5318..5659
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3436
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..4306
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4404
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4632
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4799
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..5274
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5597
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5598..7091
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacagaaag cagaagcctc atctccagtc ccttaccttt cgcctgaaac
     3241 aaacccagca tcatcagcct ctgcagttaa gcataatgta aatttaacta atgtcaacct
     3301 ggaggagccc accccagctc ctcccacctc gcacgtatca caagctgatt gtttaggagc
     3361 accaagtcct gaggcacctc acacgatgct cagagacgaa ggagtgtcat tgccgtcgca
     3421 tgtagaccca gcaaaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3481 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3541 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3601 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3661 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3721 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3781 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3841 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3901 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3961 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     4021 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     4081 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     4141 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     4201 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4261 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4321 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4381 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4441 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4501 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4561 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4621 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4681 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4741 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4801 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4861 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4921 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4981 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     5041 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     5101 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     5161 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     5221 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5281 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5341 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5401 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5461 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5521 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtgc
     5581 gtccatgact cctgacggtg accctaaaac ttggcaaaac aagtgtcttc ctggagatcc
     5641 gaattacctt gttggagcca actgtgtttc tgtcctgatt gaccactttt aattcttaga
     5701 gtctagcagc tggactaagc agtgtgaaca tggattgaac ttactgaatg gaaccactct
     5761 aatgagtatt ctattttctt agaatttata ctgcagttag tagtattaaa catttgttgg
     5821 aactgataaa ggttagtgag catgcccctg aaccacgatc agaaaacatg ctacaagctg
     5881 tgtgttattg agtggagaac tgtcaggcat tggctagagg ttcaaagata ttttgctttg
     5941 taatgatttt tgtacttttt tatggtcact gcttaacttc acatactgat ttccgttaaa
     6001 aataccagcc agtaaatggg ggtgcatttg agttttgttc tttccaaagt acactcaacc
     6061 tttactatgg ccttggccta gcatacacat ttattttatt atgcatgagg taatgtgcac
     6121 acatttttta caaatgcacc tggaatatat aaccagtgta gtggatttaa cagaaatgta
     6181 cagcaggggg atttataact tggggaggga ggggcaaatg aagacaattc cttattgtat
     6241 atgaaaacac atttctctta gggaaggaca ccaaagcatg tgagcccagt tccatggccg
     6301 ctgaatctat aaattaacat atcaccacag acatccaacc agcaggaatg ccttaccctc
     6361 atggttttca ttcttagatc atttcgctct gtagtactaa gtttttatga gtttgtgcgt
     6421 acctagatac tgtatcatgg aaaagactga ggaaattgtg gacttgatgg tttcggaaat
     6481 gtgtaaatca cctggaagaa agtaatggtg tgacttaaaa tatttttttt tgacaaggga
     6541 gagtggttgg tggtcttctg ttctttgggc tatgcatctg agatgtttga tgtgttcagg
     6601 acgcatgtac ataatgcgtg cataccactt ttgttcttgg tttgtaaatt aacttttata
     6661 aactttacct ttttatacat aaacagaacc gagtttctaa ggctaccttt gtattctctc
     6721 ctgtacctct tgagccttga actttgacct ctgcagcaat aaagcagcat ttctacacat
     6781 ataaggtcat ttttttaaga aaaagaatgc acagagttgt tacattttta agtgctgcat
     6841 ttaaaagata cagttactct agtttgatta aattcttgca aagtatccct tctgtaaaat
     6901 ttgtgataca atgctgtgcc ctaaagtgta tttttttact aatagtttat tatggcacat
     6961 cagcacgatt tctgtttaga taatacacca ctacattctg ttaataatca ttaggtgtga
     7021 aaggatttct tttgtggtta ttaaaaatct caaatttcta aatctgcaag aataaaactt
     7081 tttaaaatac a
//
LOCUS       NM_001437527            2996 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 2, mRNA.
ACCESSION   NM_001437527 XM_063277540
VERSION     NM_001437527.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277540.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77026.1,
                                           SRR26360181.2458730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000018.1  30381055-30381175
            122-291             JAXUCZ010000018.1  30385958-30386127
            292-453             JAXUCZ010000018.1  30386679-30386840
            454-605             JAXUCZ010000018.1  30387819-30387970
            606-1148            JAXUCZ010000018.1  30394747-30395289
            1149-1377           JAXUCZ010000018.1  30396391-30396619
            1378-1550           JAXUCZ010000018.1  30399772-30399944
            1551-1681           JAXUCZ010000018.1  30401686-30401816
            1682-2996           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2996
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..121
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            122..291
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    240..242
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            292..453
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1739
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 1"
                     /protein_id="NP_001424456.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTA
                     QASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCF
                     NSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCS
                     SVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAIC
                     SSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKA
                     LEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKH
                     FTDPDSPCFNRLFHAVDVNGDIWEDEIED"
     misc_feature    324..704
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    324..704
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    951..1127
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    951..1127
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1212..1382
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1212..1382
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1479..1682
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1479..1682
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            454..605
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1148
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1377
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1550
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1681
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..2996
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccaacc ttgagactct cttgaggtga ttcttgaacc cctttgctct ttacatctga
       61 gagatcacaa ggtatctggt tctattggag gttctctttt ctcccttcgc atcgttaaag
      121 gatggcagaa tttctgtagt atattggatg caaatcccac atcttggttt cttatccagc
      181 ttcagtctag cttcactggc tagaaaataa atgggatttg cacaaattcc aagccacagt
      241 gaaataacgc ttgcagcatt gatatccttt tctcctcgtt gttactaaca gaaaattcaa
      301 tgtcggcaga agacctggaa gcccaggagg atgaactact ggccctggca agtatttatg
      361 atggagatga gtttagaaaa gcagagtctg tccaaggagg ggaaaccagg atctatttgg
      421 atctgccaca gaatttcaag atattcgtga gcggcaattc aaatgagtgt ctccagaata
      481 gtggctttga atacaccatt tgctttctgc caccacttgt gctgaacttt gaactgccac
      541 cagattatcc atcctcctcc ccaccttcat tcacacttag tggcaaatgg ctgtcaccaa
      601 ctcagctctc tgctctctgc aagcacctgg acaacctgtg ggaagaacac cgaggccgtg
      661 tggtgctgtt tgcctggatg cagtttctta aggaggagac ccttacctac ctgaatattg
      721 tctctccttt tgagctcaag atggggtctc agaaaaaggt tcagagaagg acaacagctc
      781 aggcctcttc caacacagag cttgctttgg gaggagctgc tgctgctgct gctgcgtcag
      841 atgtagacca agaagacagt gtggatgaga gagctgtaca ggatgtagaa tcattgtcaa
      901 gtctgatcca ggaaatcttg gacttcaatc aagatcgaca gatgaagtgc ttcaatagta
      961 aactgttctt gtgcagtatc tgtttctgtg agaagctggg gagtgattgt atgtacttct
     1021 tggagtgcag acatgtatat tgcaaagcct gtctgaagga ttactttgaa atccagatca
     1081 aagatggtca agttaaatgc ctcaactgtc cagaaccaca gtgttcttcg gtggctactc
     1141 ctggtcaggt caaagagctg gtagaagcag acttatttgc tcgctatgac cgcctcctcc
     1201 tccagtctac tttggatcta atggcagatg tggtgtattg tccccgtcca tgctgccagc
     1261 tccctgtgat gcaagagcct ggtggcacca tggctatctg ctccagctgc aattttgcct
     1321 tctgcacctt atgcagactg acctatcacg gggtttctcc atgtaaggta acggcagaga
     1381 aattaataga cttacggaat gaatacctac aagcagatga agctactaaa aggttcttgg
     1441 aacagaggta tggcaagagg gtgattcaga aggccctgga ggagatggag agtaaagact
     1501 ggctggagaa gaactccaag agctgcccct gctgtggaac gcccatacag aaattagacg
     1561 gctgcaacaa gatgacctgt actggctgta tgcagtattt ctgctgggtt tgcatgggct
     1621 ctctctcaag agcaaaccct tacaaacatt tcactgatcc tgattctcca tgctttaaca
     1681 ggttgttcca tgccgtggat gtcaatggag acatttggga agatgagatt gaggactagt
     1741 tcattcctgc tcgcaatgta gaaatggaat ggtttgccct gaccttctgt caagtacaca
     1801 aagagccctc gcaggatatt tagggtacca tctattcact cttcagtgta gaaggaagaa
     1861 cagggtttat attttccttt ggttctactg attaaggcac gtacatttcc atgtaacata
     1921 atctgataaa attatatgcc aaaggatcag aaatgaaaac tatagattaa atattataat
     1981 atgcccaaac tgtgaatagt taaaaagtaa atatttattt tctcccccaa gctttaggtt
     2041 agggagaggg tcaagagtta agcttttaga ccatgtccaa gaagcccctg cagctgggga
     2101 cagtcacagc cccagccaca ctgtcctggg agcctgatcc attctctgta cactgctcat
     2161 ttccattcgt gctttggaga gagcctctgc tctgtaactg accaaatgtc cagtgttgtt
     2221 ctgttgtact gcttgccaga atagaaatct ataataaatt aaaaaatatt tttagtatta
     2281 taatccctgt gggtcacttg atatttatga atagtgtatt gaatcccctg gtttagagcc
     2341 aaatgtagaa tttaggattc tggctcagaa ttcctctaga ttcagagtca gagctgtctg
     2401 tgctcccttt tgttctcagc tttctccctt tgcctcccac cttctgttgg caagtacagt
     2461 tttaatgttg attacagcag tgtgtgtctt tatttcctct gctagaatag aaaagagccc
     2521 aatatattcc tcatgaatgc tctctgaacc tgtgaacagc atcatggttc taccccacct
     2581 tctgaacact cgggaattgg gcttcctccc ctcccctccc ctcgtagaca gcagtgtttg
     2641 gagtgataat agtagcttga tagctagatt cctaaccctg gcttttattg gctttttgaa
     2701 aaactgtctt cctcctgatt ccctaagtgg cttggtgtag tcacttggtg gatgttttgg
     2761 aaaggacagt aactcacctg tagcttgtga acttgtgttt tctactgtga cattgaaaat
     2821 taaggattgc ttaactgtca gctcaaactg ttgctggatt gtcaatgagg atgcttaatc
     2881 ttaacaataa agtaatttaa aatcatcccg taattggagt aggcatggtg tctgttgctt
     2941 ctgtcaccaa agcactgact gaattaaaac tgactgtgtt tctgtttgtt ctgtta
//
LOCUS       NM_001437517            3523 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 like 4A
            (Epb41l4a), transcript variant 4, mRNA.
ACCESSION   NM_001437517 XM_039096875
VERSION     NM_001437517.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3523)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096875.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1175              JAXUCZ010000018.1  25888201-25889375   c
            1176-1280           JAXUCZ010000018.1  25802641-25802745   c
            1281-1332           JAXUCZ010000018.1  25773271-25773322   c
            1333-1411           JAXUCZ010000018.1  25768091-25768169   c
            1412-1490           JAXUCZ010000018.1  25762381-25762459   c
            1491-1611           JAXUCZ010000018.1  25761136-25761256   c
            1612-1699           JAXUCZ010000018.1  25759154-25759241   c
            1700-1788           JAXUCZ010000018.1  25756917-25757005   c
            1789-1852           JAXUCZ010000018.1  25756320-25756383   c
            1853-1944           JAXUCZ010000018.1  25743152-25743243   c
            1945-2022           JAXUCZ010000018.1  25741649-25741726   c
            2023-2144           JAXUCZ010000018.1  25736039-25736160   c
            2145-2235           JAXUCZ010000018.1  25715494-25715584   c
            2236-2319           JAXUCZ010000018.1  25711524-25711607   c
            2320-2433           JAXUCZ010000018.1  25710913-25711026   c
            2434-2481           JAXUCZ010000018.1  25708322-25708369   c
            2482-2559           JAXUCZ010000018.1  25707400-25707477   c
            2560-2679           JAXUCZ010000018.1  25694243-25694362   c
            2680-2727           JAXUCZ010000018.1  25686822-25686869   c
            2728-2796           JAXUCZ010000018.1  25685951-25686019   c
            2797-2907           JAXUCZ010000018.1  25681986-25682096   c
            2908-2989           JAXUCZ010000018.1  25681789-25681870   c
            2990-3523           JAXUCZ010000018.1  25680164-25680697   c
FEATURES             Location/Qualifiers
     source          1..3523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3523
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="erythrocyte membrane protein band 4.1 like 4A"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
     exon            1..1175
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1280
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1332
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1411
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1388..1390
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="upstream in-frame stop codon"
     exon            1412..1490
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1611
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             1610..3124
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="isoform 3 is encoded by transcript variant 4;
                     erythrocyte protein band 4.1-like 4a; band 4.1-like
                     protein 4A"
                     /codon_start=1
                     /product="band 4.1-like protein 4A isoform 3"
                     /protein_id="NP_001424446.1"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
                     /translation="MGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPV
                     GVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWK
                     CSVEHHTFFRMPETESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLSIQLPRPNQNV
                     VRSRSKTYPKRVAQTQPAGSNSINRMTANLENGENEGTTKIIAPSPVKSFKKAKNENS
                     PDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPCTRQRNLSCGSDNDSSQPMRRRK
                     AHHSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRIRQENDMVDSAPQWEAV
                     LRRQKEKNQVDPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGLSEEQLKEIPY
                     TKVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVPPLPVTRSSDA
                     QGSGGSTVHQRRNGSKDSLIEEKSQLSTTNLAGKHTAKTIKTIQAARLKTDVTG"
     misc_feature    <1613..1690
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    <1613..1690
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1676..1945
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    1676..1945
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    order(1700..1702,1751..1753,1757..1759,1775..1777)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1700..1702,1751..1753,1757..1759,1775..1777)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1787..1789,1802..1813,1910..1912,1922..1924,
                     1931..1936)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1787..1789,1802..1813,1910..1912,1922..1924,
                     1931..1936)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1910..1945
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1910..1945
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1988..2122
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     misc_feature    1988..2122
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     exon            1612..1699
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1788
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1852
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1944
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2022
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2144
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2235
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2319
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2433
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2481
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2559
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2679
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2727
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2796
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2907
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..2989
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3523
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacctgca ggcacccagc cagactgacc acctccgccc cgccctccgc ccccggctga
       61 gaccccgccc tgaagggggg cgctcgggtc accgtcccgg ggctatccag cttcagatcc
      121 gaggcttttt gccgacaccc cgggccggga cccgctgtac ctgggctgct ccctccaggg
      181 ccccgccctg cgcgccacca agaactttcc ctggagcctc ggaggcctgg cgccccgggt
      241 tctgccgcgc cgcccgcagg tcctcagaca cccggctttt ccaggacgtt cggggaagga
      301 agcttgaact tggccatctc cgcgggatga gttcggggac cttcggacag aagctacagg
      361 ccgcgacaag ctgacctccc ccggttggtt tcctggagcc ctggtcggtc cccgggcagt
      421 gagagtggcg gagggagtgg cgaccttcgc cggtagccct gcgtcccagt cctggtcacc
      481 ctcgacacaa aagagaagct gagcgctctg gactctgcct tccctgttag gggctgcggg
      541 gcggggtcgg cgctggaagt gcgcgcccgg cgaggactcg ggagctgcgg ctggggaatc
      601 gctccagtgc tagcgttggg ctggcgctgc ggagtaccga ggggcatcag agtccaggga
      661 aggtctggag ggctcgtccc gcccttttcg tgtctcgggt cggcggacct tagccaggtg
      721 attcttgttg tcctcaggtc gccgccccat tcttcagaag aggagctgct gccgcaggat
      781 gcgcggggac gcgccacccc tggttcccag ttctgcggac gcttctcggg cgactccggg
      841 ctcttgacgc cccgaggcgc gctcgccctc ccgccttcgc tgtccgagcc tctcggggtg
      901 ccttcggctc accatagaac cccagacctt accctcaccc ggggggcccc acccagaccc
      961 gcgcctctcg ccctctacac ggcgcgcaca ataaattaat gcttcgcgct tgaggggagg
     1021 cggcggcggg cgccgcggtc gctgctctcg cctgactgga gacgctttca gccgacatgg
     1081 gctgtttctg cgccgttccg gaagaatttt actgcgaagt tttgctcctg gacgagtcca
     1141 agctcaccct caccacccag caccagggca tcaagaagtc aaccaaaggt tccgttgtcc
     1201 ttgaccatgt tttccgtcac gtaaacctcg tggagataga ttattttggt ctgcgatact
     1261 gcgacagaag ccatcagaca tattggctgg atcccgcaaa aactcttgca gaacacaagg
     1321 aactaatcaa cactggacct ccgtatactt tgtattttgg tattaaattc tatgctgaag
     1381 atccatgtaa gctcaaagaa gagataacca ggtgaagcaa gatgcccttc agggccgtct
     1441 gccttgtcct gtcaatattg ccgctcagct gggagcctat gccatccagg ccgaactggg
     1501 agaccacgac ccatgtaagc acactgcggg gtacgtgtcg gagtaccggt ttgttcctga
     1561 tcagaaggaa gaactggaag aatctataga aaggattcac aagactctaa tgggtcaggc
     1621 tccttccgaa gctgagctga attacttgag gactgcgaaa tccctggaga tgtacggcgt
     1681 tgacctccat cctgtctatg gagaaaataa gtccgagtat ttcttaggat tgactccagt
     1741 gggtgttgtc gtctataaga ataaaaagca agtggggaag tatttctggc ctcggattac
     1801 caaggtgcac ttcaaggaaa cccagtttga actcagagtc ttgggaaaag actgtaatga
     1861 gacctcgttc ttttttgaag ctcggagcaa aactgcttgc aaacacctct ggaaatgcag
     1921 tgtggagcac catacatttt tcaggatgcc agaaacagag tcaaattcac tgtcaagaaa
     1981 actcagcaag tttgggtcca taagttataa acaccgatac agtggcagga cagctttgca
     2041 aatgagccga gatctttcca tccaacttcc ccggcccaac cagaacgtgg tgagaagtcg
     2101 aagcaagact taccccaaga gggtagcaca gacgcagccc gctggatcca acagcatcaa
     2161 tcggatgact gcaaacttgg aaaacgggga gaatgaagga accaccaaga tcattgcgcc
     2221 ctcaccagtg aaaagtttta agaaagcaaa gaatgaaaac agtcctgacc cccaaagaag
     2281 caaatctcat gcaccatggg aagaaaacgg accccagagt ggactctaca actcccccag
     2341 tgaccgcact aagtcaccaa agtttccctg tacccggcag cgcaacctct cctgtggcag
     2401 cgacaatgac tcctcgcagc caatgaggcg aaggaaggct caccacagtg gggaagactc
     2461 ggatctaaag caacggagga ggtcacgctc acgctgtaac acgagcagtg gtagtgagtc
     2521 agaaaattct aacagagaac accggaagaa gagaaacaga atacgacagg agaatgacat
     2581 ggttgattca gcgcctcagt gggaagccgt gttaaggaga cagaaggaga aaaaccaagt
     2641 ggatcctaac aaccggagat ccaggcacag atctcgctcg agaagtcctg atatccaagc
     2701 aaaagaagaa ctgtggaagc atatccagaa ggagcttgtg gacccatccg ggttgtcaga
     2761 ggagcagttg aaagagatcc catacactaa agtggagact cagggtgacc ctgtccgcat
     2821 caggcattcg cattccccaa ggagttaccg gcagtaccgc agatcccagt gctcagacgg
     2881 agagcgatcc gtcctctcgg aagtgaactc aaagacagat cttgtaccac cacttccagt
     2941 cacccgttcc tcagatgctc aggggtctgg aggctctaca gttcatcaga gaagaaacgg
     3001 gtctaaagac agcctgattg aagaaaaatc tcagctttct acaaccaacc tggctggaaa
     3061 acatacagca aaaacaataa aaaccatcca ggctgctcgg ctcaagacag acgtcactgg
     3121 gtgaaggggt gtagggaaac gtgtgtcact ggtacttttc aaactgtgaa ttagataatt
     3181 acccacgtat cttggactcg tgtccttagc acaagaaaat tggcatcttt taaggattta
     3241 tgtacagcat tcttgtgctg tgggcctttg gaaggacaac cttatgaact cactggatac
     3301 caccatctct ttcctgaaat tctgaccatc caactgtgtt tctcacctct ccaccacagc
     3361 caagaccaga ggcttcagat gagcccctgg actcccagct gccatcagac tgtagtgact
     3421 tttattccca caactgtttg taatattgta ttttgtgaca tttaagtccc aatggttatt
     3481 tacaaataat gtaaaaagct gttaagtgtt gatttgaatt taa
//
LOCUS       NM_001437451            1798 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 9, mRNA.
ACCESSION   NM_001437451 XM_063284121
VERSION     NM_001437451.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284121.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2984.1,
                                           SRR26360181.1869169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-626             JAXUCZ010000001.1  104572249-104572332
            627-913             JAXUCZ010000001.1  104572931-104573217
            914-1108            JAXUCZ010000001.1  104574234-104574428
            1109-1282           JAXUCZ010000001.1  104574810-104574983
            1283-1418           JAXUCZ010000001.1  104576616-104576751
            1419-1618           JAXUCZ010000001.1  104577665-104577864
            1619-1798           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1798
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1775
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 9 is encoded by transcript variant 9; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     9"
                     /protein_id="NP_001424380.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKL
                     EAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQK
                     VSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSA
                     RGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHV
                     LNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHK
                     KILPSPVSPAAPTLLSPGAGAPGLGQTRQGRGPELHPSAGPRRSRSGQEPTADGQDEA
                     GVRTEAEGMGGGEKVATLDYMHLKMCSLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGG
                     PGSEQ"
     misc_feature    135..1772
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..1772
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>716
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..626
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..913
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1108
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1282
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1418
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1798
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 aggagaactg ccgcaaggtg acccgttcag tggaagacgc tgaaatcaaa accaatgtcc
      601 tgaagcagaa ctctgccttg ttggaggaga agctaagata cctccagcag caactgcagg
      661 atgagacgcc ccggagacag gaggccgagt tgcaggagct ggagcaaaaa ctagaggctg
      721 gcctctcccg gcatggccta ggccctacta ctcccattca gggctgctcc ggtcctcctg
      781 gtagcccgga ggaacccccg cggccgcgag gcctgccctc caatggctgg ggcatggcaa
      841 tccgcgcagg ggagggaccc tcgctgagcg agcaggagtt gcagaaggtc tccagcggcc
      901 tagaggagct gaggagggag gtgtcctcgc tggcagctcg gtggcatcag gaggaggggg
      961 cggtgcagga ggccctaagg ttgctgggag gcctgggcgg ccgtctggat ggctttctgg
     1021 gccaatggga gcgggcgcag cgggaacaag cacagtccgc acggggtttg caggagctgc
     1081 gaggacgagc agatgagctg tgcactatgg tggagaggtc agcagtgtct gtcgcttcac
     1141 tgaggagcga actggaggca ctgggcccag taaaaccgat tctggaggag ctgggacggc
     1201 aacttcaaaa ctcccgaagg ggacctgacc atgtcttgaa cttggatcgt cctgcccaag
     1261 gtccctgtcc tcgatgtgcc agccaggggc agcagttatc cacggagtcc ctacagcagc
     1321 tgctggaacg tgcgctgacc ccactggtgg acgaagtgaa gcagaagggt ctggctcctg
     1381 cctgccccag ttgccagagg ctacacaaga agattctgcc cagtccagta agcccagcgg
     1441 cgcctacact cctctcccca ggagctggag cgccaggcct tggccaaaca cgtcagggca
     1501 gaggccctga gctccaccct tcggctggcc caagacgaag ccgttcgggc caagaaccta
     1561 ctgctgacgg acaagatgaa gccggagtga ggacggaggc agagggcatg ggaggagggg
     1621 agaaggtggc cactttggac tatatgcatt tgaagatgtg ttccctccac gaccaactca
     1681 gccacctgcc acttgagggg tccacagggg caatgggggg aggaagcact ggaggggctc
     1741 cccctaaacg tgggggtcca ggctctgaac aataaatggc ctctcatgct ggcatgaa
//
LOCUS       NM_001034995            2936 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 1, mRNA.
ACCESSION   NM_001034995 XM_001066493
VERSION     NM_001034995.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001034995.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103648.1, SRR26360176.116176.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000018.1  30383845-30383905
            62-231              JAXUCZ010000018.1  30385958-30386127
            232-393             JAXUCZ010000018.1  30386679-30386840
            394-545             JAXUCZ010000018.1  30387819-30387970
            546-1088            JAXUCZ010000018.1  30394747-30395289
            1089-1317           JAXUCZ010000018.1  30396391-30396619
            1318-1490           JAXUCZ010000018.1  30399772-30399944
            1491-1621           JAXUCZ010000018.1  30401686-30401816
            1622-2936           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2936
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..61
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            62..231
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    180..182
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            232..393
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1679
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 1"
                     /protein_id="NP_001030167.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTA
                     QASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCF
                     NSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCS
                     SVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAIC
                     SSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKA
                     LEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKH
                     FTDPDSPCFNRLFHAVDVNGDIWEDEIED"
     misc_feature    264..644
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    264..644
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    891..1067
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    891..1067
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1152..1322
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1152..1322
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1419..1622
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1419..1622
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            394..545
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1088
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1317
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1490
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1621
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..2936
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaagtgc aaggttcgtt ttaaaagaag acagtatctg ttggggaaca accgtgtgga
       61 gatggcagaa tttctgtagt atattggatg caaatcccac atcttggttt cttatccagc
      121 ttcagtctag cttcactggc tagaaaataa atgggatttg cacaaattcc aagccacagt
      181 gaaataacgc ttgcagcatt gatatccttt tctcctcgtt gttactaaca gaaaattcaa
      241 tgtcggcaga agacctggaa gcccaggagg atgaactact ggccctggca agtatttatg
      301 atggagatga gtttagaaaa gcagagtctg tccaaggagg ggaaaccagg atctatttgg
      361 atctgccaca gaatttcaag atattcgtga gcggcaattc aaatgagtgt ctccagaata
      421 gtggctttga atacaccatt tgctttctgc caccacttgt gctgaacttt gaactgccac
      481 cagattatcc atcctcctcc ccaccttcat tcacacttag tggcaaatgg ctgtcaccaa
      541 ctcagctctc tgctctctgc aagcacctgg acaacctgtg ggaagaacac cgaggccgtg
      601 tggtgctgtt tgcctggatg cagtttctta aggaggagac ccttacctac ctgaatattg
      661 tctctccttt tgagctcaag atggggtctc agaaaaaggt tcagagaagg acaacagctc
      721 aggcctcttc caacacagag cttgctttgg gaggagctgc tgctgctgct gctgcgtcag
      781 atgtagacca agaagacagt gtggatgaga gagctgtaca ggatgtagaa tcattgtcaa
      841 gtctgatcca ggaaatcttg gacttcaatc aagatcgaca gatgaagtgc ttcaatagta
      901 aactgttctt gtgcagtatc tgtttctgtg agaagctggg gagtgattgt atgtacttct
      961 tggagtgcag acatgtatat tgcaaagcct gtctgaagga ttactttgaa atccagatca
     1021 aagatggtca agttaaatgc ctcaactgtc cagaaccaca gtgttcttcg gtggctactc
     1081 ctggtcaggt caaagagctg gtagaagcag acttatttgc tcgctatgac cgcctcctcc
     1141 tccagtctac tttggatcta atggcagatg tggtgtattg tccccgtcca tgctgccagc
     1201 tccctgtgat gcaagagcct ggtggcacca tggctatctg ctccagctgc aattttgcct
     1261 tctgcacctt atgcagactg acctatcacg gggtttctcc atgtaaggta acggcagaga
     1321 aattaataga cttacggaat gaatacctac aagcagatga agctactaaa aggttcttgg
     1381 aacagaggta tggcaagagg gtgattcaga aggccctgga ggagatggag agtaaagact
     1441 ggctggagaa gaactccaag agctgcccct gctgtggaac gcccatacag aaattagacg
     1501 gctgcaacaa gatgacctgt actggctgta tgcagtattt ctgctgggtt tgcatgggct
     1561 ctctctcaag agcaaaccct tacaaacatt tcactgatcc tgattctcca tgctttaaca
     1621 ggttgttcca tgccgtggat gtcaatggag acatttggga agatgagatt gaggactagt
     1681 tcattcctgc tcgcaatgta gaaatggaat ggtttgccct gaccttctgt caagtacaca
     1741 aagagccctc gcaggatatt tagggtacca tctattcact cttcagtgta gaaggaagaa
     1801 cagggtttat attttccttt ggttctactg attaaggcac gtacatttcc atgtaacata
     1861 atctgataaa attatatgcc aaaggatcag aaatgaaaac tatagattaa atattataat
     1921 atgcccaaac tgtgaatagt taaaaagtaa atatttattt tctcccccaa gctttaggtt
     1981 agggagaggg tcaagagtta agcttttaga ccatgtccaa gaagcccctg cagctgggga
     2041 cagtcacagc cccagccaca ctgtcctggg agcctgatcc attctctgta cactgctcat
     2101 ttccattcgt gctttggaga gagcctctgc tctgtaactg accaaatgtc cagtgttgtt
     2161 ctgttgtact gcttgccaga atagaaatct ataataaatt aaaaaatatt tttagtatta
     2221 taatccctgt gggtcacttg atatttatga atagtgtatt gaatcccctg gtttagagcc
     2281 aaatgtagaa tttaggattc tggctcagaa ttcctctaga ttcagagtca gagctgtctg
     2341 tgctcccttt tgttctcagc tttctccctt tgcctcccac cttctgttgg caagtacagt
     2401 tttaatgttg attacagcag tgtgtgtctt tatttcctct gctagaatag aaaagagccc
     2461 aatatattcc tcatgaatgc tctctgaacc tgtgaacagc atcatggttc taccccacct
     2521 tctgaacact cgggaattgg gcttcctccc ctcccctccc ctcgtagaca gcagtgtttg
     2581 gagtgataat agtagcttga tagctagatt cctaaccctg gcttttattg gctttttgaa
     2641 aaactgtctt cctcctgatt ccctaagtgg cttggtgtag tcacttggtg gatgttttgg
     2701 aaaggacagt aactcacctg tagcttgtga acttgtgttt tctactgtga cattgaaaat
     2761 taaggattgc ttaactgtca gctcaaactg ttgctggatt gtcaatgagg atgcttaatc
     2821 ttaacaataa agtaatttaa aatcatcccg taattggagt aggcatggtg tctgttgctt
     2881 ctgtcaccaa agcactgact gaattaaaac tgactgtgtt tctgtttgtt ctgtta
//
LOCUS       NM_001437499            6830 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 7, mRNA.
ACCESSION   NM_001437499 XM_063284370
VERSION     NM_001437499.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6830)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6830)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6830)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6830)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6830)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6830)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6830)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6830)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6830)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6830)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.3340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-4066           JAXUCZ010000001.1  128277918-128278787 c
            4067-4164           JAXUCZ010000001.1  128277712-128277809 c
            4165-4392           JAXUCZ010000001.1  128276273-128276500 c
            4393-4559           JAXUCZ010000001.1  128271583-128271749 c
            4560-5034           JAXUCZ010000001.1  128266965-128267439 c
            5035-5252           JAXUCZ010000001.1  128265159-128265376 c
            5253-5336           JAXUCZ010000001.1  128263837-128263920 c
            5337-6830           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..6830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6830
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5431
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 7 is encoded by transcript variant 7; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 7"
                     /protein_id="NP_001424428.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASR
                     DLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHP
                     RDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHN
                     RYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLI
                     PSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDV
                     NDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRS
                     NHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSK
                     GKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNS
                     VSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKT
                     ITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKA
                     HSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVAT
                     ARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETL
                     LSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3707..4936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    5078..5398
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     misc_feature    5078..5398
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..4066
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4164
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4392
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..5034
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5252
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5336
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..6830
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3241 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3301 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3361 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3421 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3481 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3541 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3601 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3661 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3721 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     3781 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     3841 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     3901 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     3961 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4021 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4081 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4141 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4201 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4261 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4321 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4381 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4441 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4501 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4561 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4621 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4681 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4741 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     4801 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     4861 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     4921 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     4981 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5041 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5101 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5161 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5221 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5281 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtga
     5341 ccctaaaact tggcaaaaca agtgtcttcc tggagatccg aattaccttg ttggagccaa
     5401 ctgtgtttct gtcctgattg accactttta attcttagag tctagcagct ggactaagca
     5461 gtgtgaacat ggattgaact tactgaatgg aaccactcta atgagtattc tattttctta
     5521 gaatttatac tgcagttagt agtattaaac atttgttgga actgataaag gttagtgagc
     5581 atgcccctga accacgatca gaaaacatgc tacaagctgt gtgttattga gtggagaact
     5641 gtcaggcatt ggctagaggt tcaaagatat tttgctttgt aatgattttt gtactttttt
     5701 atggtcactg cttaacttca catactgatt tccgttaaaa ataccagcca gtaaatgggg
     5761 gtgcatttga gttttgttct ttccaaagta cactcaacct ttactatggc cttggcctag
     5821 catacacatt tattttatta tgcatgaggt aatgtgcaca cattttttac aaatgcacct
     5881 ggaatatata accagtgtag tggatttaac agaaatgtac agcaggggga tttataactt
     5941 ggggagggag gggcaaatga agacaattcc ttattgtata tgaaaacaca tttctcttag
     6001 ggaaggacac caaagcatgt gagcccagtt ccatggccgc tgaatctata aattaacata
     6061 tcaccacaga catccaacca gcaggaatgc cttaccctca tggttttcat tcttagatca
     6121 tttcgctctg tagtactaag tttttatgag tttgtgcgta cctagatact gtatcatgga
     6181 aaagactgag gaaattgtgg acttgatggt ttcggaaatg tgtaaatcac ctggaagaaa
     6241 gtaatggtgt gacttaaaat attttttttt gacaagggag agtggttggt ggtcttctgt
     6301 tctttgggct atgcatctga gatgtttgat gtgttcagga cgcatgtaca taatgcgtgc
     6361 ataccacttt tgttcttggt ttgtaaatta acttttataa actttacctt tttatacata
     6421 aacagaaccg agtttctaag gctacctttg tattctctcc tgtacctctt gagccttgaa
     6481 ctttgacctc tgcagcaata aagcagcatt tctacacata taaggtcatt tttttaagaa
     6541 aaagaatgca cagagttgtt acatttttaa gtgctgcatt taaaagatac agttactcta
     6601 gtttgattaa attcttgcaa agtatccctt ctgtaaaatt tgtgatacaa tgctgtgccc
     6661 taaagtgtat ttttttacta atagtttatt atggcacatc agcacgattt ctgtttagat
     6721 aatacaccac tacattctgt taataatcat taggtgtgaa aggatttctt ttgtggttat
     6781 taaaaatctc aaatttctaa atctgcaaga ataaaacttt ttaaaataca
//
LOCUS       NM_001437492            7130 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001437492 XM_063284350
VERSION     NM_001437492.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7130)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7130)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7130)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7130)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 7130)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 7130)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 7130)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 7130)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 7130)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 7130)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2304236.1,
                                           SRR26643290.2199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-3436           JAXUCZ010000001.1  128279474-128279713 c
            3437-4306           JAXUCZ010000001.1  128277918-128278787 c
            4307-4404           JAXUCZ010000001.1  128277712-128277809 c
            4405-4632           JAXUCZ010000001.1  128276273-128276500 c
            4633-4799           JAXUCZ010000001.1  128271583-128271749 c
            4800-5274           JAXUCZ010000001.1  128266965-128267439 c
            5275-5492           JAXUCZ010000001.1  128265159-128265376 c
            5493-5636           JAXUCZ010000001.1  128263777-128263920 c
            5637-7130           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..7130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..7130
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5731
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 1 is encoded by transcript variant 1; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 1"
                     /protein_id="NP_001424421.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQAD
                     CLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQR
                     LDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYE
                     DQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYE
                     QLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPP
                     GFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQS
                     VLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDK
                     TLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGH
                     HSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQP
                     VPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQT
                     FYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPS
                     ETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKA
                     VPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEI
                     YFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFA
                     LKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2906..3256
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3500..3559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3644..3646
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3707..5188
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3848..3850
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3881..4543
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Actin-binding region (ABR).
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    3923..3925
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4490..4492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4526..4528
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4664..4666
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5057..5059
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5273..5275
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5330..5626
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     misc_feature    5330..5626
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3436
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..4306
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4404
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4632
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4799
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..5274
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5636
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5637..7130
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacagaaag cagaagcctc atctccagtc ccttaccttt cgcctgaaac
     3241 aaacccagca tcatcagcct ctgcagttaa gcataatgta aatttaacta atgtcaacct
     3301 ggaggagccc accccagctc ctcccacctc gcacgtatca caagctgatt gtttaggagc
     3361 accaagtcct gaggcacctc acacgatgct cagagacgaa ggagtgtcat tgccgtcgca
     3421 tgtagaccca gcaaaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3481 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3541 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3601 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3661 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3721 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3781 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3841 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3901 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3961 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     4021 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     4081 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     4141 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     4201 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4261 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4321 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4381 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4441 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4501 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4561 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4621 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4681 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4741 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4801 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4861 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4921 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4981 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     5041 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     5101 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     5161 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     5221 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5281 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5341 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5401 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5461 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5521 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtgc
     5581 gtccatgact cctgacggtt ggtcttttgc tctaaaatca tccgactcct cgtcgggtga
     5641 ccctaaaact tggcaaaaca agtgtcttcc tggagatccg aattaccttg ttggagccaa
     5701 ctgtgtttct gtcctgattg accactttta attcttagag tctagcagct ggactaagca
     5761 gtgtgaacat ggattgaact tactgaatgg aaccactcta atgagtattc tattttctta
     5821 gaatttatac tgcagttagt agtattaaac atttgttgga actgataaag gttagtgagc
     5881 atgcccctga accacgatca gaaaacatgc tacaagctgt gtgttattga gtggagaact
     5941 gtcaggcatt ggctagaggt tcaaagatat tttgctttgt aatgattttt gtactttttt
     6001 atggtcactg cttaacttca catactgatt tccgttaaaa ataccagcca gtaaatgggg
     6061 gtgcatttga gttttgttct ttccaaagta cactcaacct ttactatggc cttggcctag
     6121 catacacatt tattttatta tgcatgaggt aatgtgcaca cattttttac aaatgcacct
     6181 ggaatatata accagtgtag tggatttaac agaaatgtac agcaggggga tttataactt
     6241 ggggagggag gggcaaatga agacaattcc ttattgtata tgaaaacaca tttctcttag
     6301 ggaaggacac caaagcatgt gagcccagtt ccatggccgc tgaatctata aattaacata
     6361 tcaccacaga catccaacca gcaggaatgc cttaccctca tggttttcat tcttagatca
     6421 tttcgctctg tagtactaag tttttatgag tttgtgcgta cctagatact gtatcatgga
     6481 aaagactgag gaaattgtgg acttgatggt ttcggaaatg tgtaaatcac ctggaagaaa
     6541 gtaatggtgt gacttaaaat attttttttt gacaagggag agtggttggt ggtcttctgt
     6601 tctttgggct atgcatctga gatgtttgat gtgttcagga cgcatgtaca taatgcgtgc
     6661 ataccacttt tgttcttggt ttgtaaatta acttttataa actttacctt tttatacata
     6721 aacagaaccg agtttctaag gctacctttg tattctctcc tgtacctctt gagccttgaa
     6781 ctttgacctc tgcagcaata aagcagcatt tctacacata taaggtcatt tttttaagaa
     6841 aaagaatgca cagagttgtt acatttttaa gtgctgcatt taaaagatac agttactcta
     6901 gtttgattaa attcttgcaa agtatccctt ctgtaaaatt tgtgatacaa tgctgtgccc
     6961 taaagtgtat ttttttacta atagtttatt atggcacatc agcacgattt ctgtttagat
     7021 aatacaccac tacattctgt taataatcat taggtgtgaa aggatttctt ttgtggttat
     7081 taaaaatctc aaatttctaa atctgcaaga ataaaacttt ttaaaataca
//
LOCUS       NM_001437494            7070 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 3, mRNA.
ACCESSION   NM_001437494 XM_063284360
VERSION     NM_001437494.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7070)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7070)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7070)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7070)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 7070)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 7070)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 7070)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 7070)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 7070)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 7070)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284360.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1918.1,
                                           SRR26643288.2692.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JAXUCZ010000001.1  128341944-128342403 c
            461-517             JAXUCZ010000001.1  128325302-128325358 c
            518-642             JAXUCZ010000001.1  128309353-128309477 c
            643-745             JAXUCZ010000001.1  128308404-128308506 c
            746-1022            JAXUCZ010000001.1  128306471-128306747 c
            1023-1126           JAXUCZ010000001.1  128303218-128303321 c
            1127-1295           JAXUCZ010000001.1  128302666-128302834 c
            1296-1443           JAXUCZ010000001.1  128302203-128302350 c
            1444-1583           JAXUCZ010000001.1  128295152-128295291 c
            1584-1689           JAXUCZ010000001.1  128294447-128294552 c
            1690-1840           JAXUCZ010000001.1  128291713-128291863 c
            1841-1949           JAXUCZ010000001.1  128289070-128289178 c
            1950-2169           JAXUCZ010000001.1  128287751-128287970 c
            2170-2354           JAXUCZ010000001.1  128287297-128287481 c
            2355-2450           JAXUCZ010000001.1  128287089-128287184 c
            2451-2533           JAXUCZ010000001.1  128284354-128284436 c
            2534-2744           JAXUCZ010000001.1  128283655-128283865 c
            2745-2845           JAXUCZ010000001.1  128283262-128283362 c
            2846-3196           JAXUCZ010000001.1  128280040-128280390 c
            3197-3436           JAXUCZ010000001.1  128279474-128279713 c
            3437-4306           JAXUCZ010000001.1  128277918-128278787 c
            4307-4404           JAXUCZ010000001.1  128277712-128277809 c
            4405-4632           JAXUCZ010000001.1  128276273-128276500 c
            4633-4799           JAXUCZ010000001.1  128271583-128271749 c
            4800-5274           JAXUCZ010000001.1  128266965-128267439 c
            5275-5492           JAXUCZ010000001.1  128265159-128265376 c
            5493-5576           JAXUCZ010000001.1  128263837-128263920 c
            5577-7070           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..7070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..7070
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..460
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    275..277
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             434..5671
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 3 is encoded by transcript variant 3; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 3"
                     /protein_id="NP_001424423.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDN
                     PHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
                     KITIRRKKKVQIPVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRS
                     ASRDRSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAA
                     RDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSD
                     SIHSANASERDDISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPS
                     NGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQV
                     GQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV
                     LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR
                     RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNH
                     KEVERGIVPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQ
                     PVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTD
                     HRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMR
                     MRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLV
                     WVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQ
                     ELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPG
                     LKTASQQKAEASSPVPYLSPETNPASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQAD
                     CLGAPSPEAPHTMLRDEGVSLPSHVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQR
                     LDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYE
                     DQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYE
                     QLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPP
                     GFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQS
                     VLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDK
                     TLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGH
                     HSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQP
                     VPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQT
                     FYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPS
                     ETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKA
                     VPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEI
                     YFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLP
                     GDPNYLVGANCVSVLIDHF"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    497..757
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(530..550,602..604,611..613,695..697,707..709,
                     716..721)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    737..1000
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    806..808
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    827..829
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    956..958
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    965..967
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    968..970
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    986..988
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    989..1222
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(989..1006,1019..1069,1076..1084,1091..1093,
                     1097..1102,1121..1123,1145..1150,1154..1159,1193..1213)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(1022..1042,1058..1060,1067..1069,1157..1159,
                     1169..1171,1178..1183)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1067..1069
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1154..1156
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1256..1258
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1262..1264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1283..1285
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1301..1303
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1313..1315
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1319..1522
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1322..1324
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1331..1333
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1400..1402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1418..1420
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1433..1435
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1442..1444
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1490..1492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1493..1495
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1697..1936
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1727..1747,1775..1777,1784..1786,1871..1873,
                     1883..1885,1892..1897)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1982..2176
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1982..1990,2072..2080,2093..2095,2102..2104,
                     2159..2161)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1988..2008,2045..2050,2057..2059,2102..2104,
                     2126..2131,2153..2161,2171..2176)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(2006..2008,2012..2014,2021..2023,2033..2035,
                     2096..2101,2156..2158,2162..2167)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2276..2815
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2282..2284
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2297..2299
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2330..3061
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Occludin (OCLN)-binding region.
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    2858..2860
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2861..2863
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2894..2896
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2897..2899
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2903..2905
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2906..3256
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2915..2917
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2942..2944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2969..2971
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2975..2977
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    2993..2995
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3014..3016
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3035..3037
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3167..3169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3308..5131
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3500..3559
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3644..3646
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3707..5188
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3848..3850
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    3881..4543
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K2P5.1); Region: Actin-binding region (ABR).
                     /evidence=ECO:0000250|UniProtKB:Q07157"
     misc_feature    3923..3925
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4490..4492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39447; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4526..4528
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    4664..4666
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5057..5059
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07157; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5273..5275
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K2P5.1); phosphorylation site"
     misc_feature    5318..5638
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     misc_feature    5318..5638
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     exon            461..517
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..745
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1022
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1295
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1583
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1689
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1840
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1949
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2169
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2354
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2450
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2533
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2744
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3196
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3436
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..4306
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4404
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4632
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4799
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..5274
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5492
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5576
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5577..7070
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggccggg tccggcaggt tttgcgtggc cgcctgagtt gcccgcgacg gctctgcccg
       61 ccgacggcac gtctctcggc ggtcgcgcgt tccggggaag ttacgtgcgg gagcagggtt
      121 ttgaggagac gcccgaaggc ggaggggaca gccggaggcc ccggtactgc ggagcggcga
      181 gcgggccgag ggcggcggag gccgagccgg cggccgggtg tgccccgcgg agaagcccgg
      241 gcggggcgga cgcttcccgg acttttgtcc cacttgaatc ccctccccgt gggccgggcc
      301 tttccggcct cccccgcccc tgccccgctt gtccccggga gatgtttatg cggacggtgg
      361 cgtgaggagc gggcgggccg gcggcgcgga gtttcgggtc cgaggagctt cgcgcggcgc
      421 ggagagagac aagatgtccg ccagggccgc ggccgctaag agcacagcaa tggaggaaac
      481 agctatatgg gaacagcaca cagtgacgct tcacagggct cctgggtttg gatttggaat
      541 tgcaatatct ggtggaagag ataatcctca ttttcagagt ggggaaacct ccatagtgat
      601 ttctgatgtg ctaaaaggag ggccagctga aggacagcta caggaaaatg accgagtcgc
      661 aatggttaac ggagtttcaa tggataatgt tgaacatgct tttgctgttc agcagctaag
      721 gaaaagtggg aaaaacgcaa aaattaccat ccgaagaaag aagaaagttc agattcctgt
      781 aagtcaccca gaccctgacc cagtgtctga taatgaagat gatagctatg acgaggatgt
      841 gcacgatcca agaagtggcc gaggtgccct agctaacaga aggggtgaga agagctgggc
      901 aagggataga agcgcaagca gggaccggag cctgtcccct cgctcagaca ggcgatcagt
      961 ggcctccagt cagcccgcca aacccaccaa ggtcacattg gtgaagtctc ggaaaaatga
     1021 agaatatggt cttcgattgg ccagccatat atttgtaaag gaaatttcac aagatagttt
     1081 ggcagcaaga gatggtaaca ttcaagaagg ggatgttgtc ctgaagataa atggtactgt
     1141 gacagaaaat atgtcactga cagatgcaaa aacattgata gaaaggtcta aaggcaagtt
     1201 aaaaatggta gtgcaaagag atgagcgggc taccttattg aatgtccctg atctttcaga
     1261 tagtatccat tctgctaatg cctctgaaag agatgacatt tcagaaattc agtcactagc
     1321 atcagaccat tcagttcgct cccatgacag gcctccccgc cgaagccagt cacgatctcc
     1381 cgaccaacgt tcagagccct ctgatcattc cacacagtct ccacagcagc ccagcaatgg
     1441 cagtctccgg agcagagagg aagagcgcat gtctaaaccc ggggctgtct caactcctgt
     1501 aaaacatgta gatgatcata cacccaaagc agtggaagaa gttacagttg aaaaacatga
     1561 gaagcagaca cccactcttc cagaaccaaa acctgtatat gctcaagtcg gacagccaga
     1621 tgtggattta cctgtcagcc cttctgatgg tgttctgcca aattcaacac atgaagatgg
     1681 gattcttagg cccagcatga aactggtaaa attcagaaaa ggagatagtg tgggtttgcg
     1741 actagctggt ggaaatgatg tcggaatatt tgtagctggc gttctagaag atagccctgc
     1801 agccaaagaa ggcttagagg aaggtgatca aattctcagg gtgaacaatg tagatttcac
     1861 aaatatcata agagaagaag ctgttctttt cctcctcgac ctccctaaag gtgaagaagt
     1921 gaccatattg gctcagaaga aaaaggacgt ttatcgccgc attgtagagt cagatgtagg
     1981 agactcgttc tatattagaa cacattttga atatgagaaa gaatctcctt atggactcag
     2041 ttttaacaaa ggagaggtgt tccgggtcgt ggacaccctg tacaacggga agctgggctc
     2101 ctggctggcc attcgaattg gcaaaaatca caaggaggta gagcgaggca tcgttcctaa
     2161 taagaacaga gccgagcagt tagccagtgt acagtacaca cttccaaaga cagcaggtgg
     2221 cgatcgggca gacttctgga ggtttcgagg tcttcgtagc tccaagagaa atcttcgaaa
     2281 aagcagagag gacctgtcag cgcagccagt tcaaacaaag ttcccagctt atgaaagggt
     2341 tgttcttcga gaagctggat tcctaagacc tgtaaccatc tttggaccga ttgctgatgt
     2401 tgccagagaa aagttagcaa gggaggagcc agacatttat cagattgcaa aaagtgaacc
     2461 acgagatgct ggaactgacc atcggagctc gggcattatt cgccttcata caataaagca
     2521 aatcatagat caagataaac atgctttatt agatgtcaca ccaaatgcag tcgatcgcct
     2581 taattatgca cagtggtatc cgattgttgt gttccttaac cctgactcta agcagggtgt
     2641 aaaaacaatg aggatgaggc tatgtccaga gtctcggaaa agtgccagga agctatatga
     2701 acggtctcat aaacttcgta aaaataatca ccatcttttt acaaccacaa ttaacttaaa
     2761 ctcaatgaat gatggttggt atggtgccct gaaagaagcg attcagcagc aacagaacca
     2821 gctggtgtgg gtctctgagg ggaaggcgga tggtgctaca agtgatgacc ttgatttgca
     2881 tgatgatcgt ctgtcctacc tgtcagcccc aggtagtgag tactcaatgt atagcacgga
     2941 cagtagacac acttctgact atgaagacac agatacagaa ggcggggcct acactgatca
     3001 agaactagat gaaactctta atgatgaggt ggggactcca ccggagtctg ctattacacg
     3061 gtcctctgag cctgtaagag aggattcctc tggaatgcat catgaaaacc aaacatatcc
     3121 tccttactca ccacaagcgc agccacaagc tattcataga atagactccc ctggacttaa
     3181 gacagcctct caacagaaag cagaagcctc atctccagtc ccttaccttt cgcctgaaac
     3241 aaacccagca tcatcagcct ctgcagttaa gcataatgta aatttaacta atgtcaacct
     3301 ggaggagccc accccagctc ctcccacctc gcacgtatca caagctgatt gtttaggagc
     3361 accaagtcct gaggcacctc acacgatgct cagagacgaa ggagtgtcat tgccgtcgca
     3421 tgtagaccca gcaaaggtat ataggaagga gccatatcct gaggaaatga tgagacaaaa
     3481 ccatatttta aaacagccag ctcttggtca tccagggcag aggctggata aagagccaaa
     3541 tccagcctat gatccccaac ttccatatgt agaaaaacaa gccagcagag accttgagca
     3601 gccaccatac aggtatgagt cctcaagcta cacagaccag ttttctcgga actatgacca
     3661 tcgcctacga tttgaagacc gagtccctac ctatgaagac cagtggtcat attatgatga
     3721 caaacagccc tacccaactc ggccctttga tactcagcat cctcgagact tggactccag
     3781 acagcatcct gaagaggctt cagaacgagg ctatttccag cgttttgaag agcccgcccc
     3841 tctgccatat gacagtagac cacgctacga gcagctgcct cgaacctcta ctctccgaca
     3901 tgaagaacag ccaaccagtg gatatgaggt gcacaacagg tacaggccag aagcacagcc
     3961 ctatgctcca gcaggtccta agtcatctga gccgaagcag tactttgacc agtacccacg
     4021 aagttatgag caagtaccac caccaggatt tacctccaaa acaggccatt acgagcctct
     4081 ccatggtgct gcagttgttc ctcctctgat accttcctct caacataagc cagaagttct
     4141 gccctcagct accaagccac agcctccgcc cccagcccta actgaggaag aggaggatcc
     4201 agcaatgaaa ccacagtctg tgctcaccag ggtcaaaatg tttgaaaaca aaagatctgc
     4261 gtctctggag aacaagaagg atgtgaatga cactgccagc tttaagcctc cagaagtagc
     4321 atctaaacct ccaagtgctt ctcttgttgg ccctaaacct gtttctcaga ctcagtttag
     4381 tgagcatgac aaaacactct acaggctccc agagcctcag aaacctcaag cgaagccacc
     4441 tgaagatatt gttcgatcaa atcattacga tcctgaagag gatgaagagt attaccggaa
     4501 acagctctct tactttgacc ggagaagttt cgagagcaag cctcctgcac atattcctgc
     4561 tggccatcac tcagagcctg ccaagccagt ccattctcag agtcagccga atttctctag
     4621 ttattcttca aaggggaaac ccgaaactga tgctatggat agatcattca gtgagaaacg
     4681 ttatgatcca acccaggcca tgcctcctcc tcctccgttg ccctcacagt acagccagcc
     4741 agttccgcct ctgtccaact cttctctcca catacattcc aaggccgccc agagtgaagg
     4801 caattccgta tcgttggatt ttcagaactc atatatatcc aaaccagacc cacccccatc
     4861 tcagagcaaa ccagcaactt ttagaccacc aacccgggag gaccctcctc agaccttcta
     4921 tccccagaaa agtttcccag acaaagcttc agttaatgga gctgagcaga ctcagaaaac
     4981 catcactcca gcatacaacc gattcacacc aaagccgtac acgagctctg cccggccatt
     5041 tgaacgcaag tttgaaagtc caaagttcaa ccataatctt ctgccaagtg aaactgtaca
     5101 taaacctgaa ttgtcttcaa aacctccccc ttctccaaaa actctcatga aggctcatag
     5161 ttccacacag ccgcctgagt ttgacagtgg agtcgagact ttctctgttc acacagataa
     5221 gcctaaatat caaataaata atatcagcac catgcctaaa gctgttcctg tgagtccttc
     5281 agctgtggaa gaagatgaag atgaggatgg tcatactgta gtggctacag cccgcggcat
     5341 ttttaacagc aatggcggtg tgttgagttc catagaaact ggtgttagta taattatccc
     5401 acaaggagcc attcctgaag gaattgagca agaaatctat ttcaaagtct gcagagacaa
     5461 tagcatcctc ccacctttag ataaagagaa aggtgaaact ctgctgagcc ccctagtgat
     5521 gtgcgggccc catggcctca agttcctgaa gcctgtggag ctacgcttgc cacactgtga
     5581 ccctaaaact tggcaaaaca agtgtcttcc tggagatccg aattaccttg ttggagccaa
     5641 ctgtgtttct gtcctgattg accactttta attcttagag tctagcagct ggactaagca
     5701 gtgtgaacat ggattgaact tactgaatgg aaccactcta atgagtattc tattttctta
     5761 gaatttatac tgcagttagt agtattaaac atttgttgga actgataaag gttagtgagc
     5821 atgcccctga accacgatca gaaaacatgc tacaagctgt gtgttattga gtggagaact
     5881 gtcaggcatt ggctagaggt tcaaagatat tttgctttgt aatgattttt gtactttttt
     5941 atggtcactg cttaacttca catactgatt tccgttaaaa ataccagcca gtaaatgggg
     6001 gtgcatttga gttttgttct ttccaaagta cactcaacct ttactatggc cttggcctag
     6061 catacacatt tattttatta tgcatgaggt aatgtgcaca cattttttac aaatgcacct
     6121 ggaatatata accagtgtag tggatttaac agaaatgtac agcaggggga tttataactt
     6181 ggggagggag gggcaaatga agacaattcc ttattgtata tgaaaacaca tttctcttag
     6241 ggaaggacac caaagcatgt gagcccagtt ccatggccgc tgaatctata aattaacata
     6301 tcaccacaga catccaacca gcaggaatgc cttaccctca tggttttcat tcttagatca
     6361 tttcgctctg tagtactaag tttttatgag tttgtgcgta cctagatact gtatcatgga
     6421 aaagactgag gaaattgtgg acttgatggt ttcggaaatg tgtaaatcac ctggaagaaa
     6481 gtaatggtgt gacttaaaat attttttttt gacaagggag agtggttggt ggtcttctgt
     6541 tctttgggct atgcatctga gatgtttgat gtgttcagga cgcatgtaca taatgcgtgc
     6601 ataccacttt tgttcttggt ttgtaaatta acttttataa actttacctt tttatacata
     6661 aacagaaccg agtttctaag gctacctttg tattctctcc tgtacctctt gagccttgaa
     6721 ctttgacctc tgcagcaata aagcagcatt tctacacata taaggtcatt tttttaagaa
     6781 aaagaatgca cagagttgtt acatttttaa gtgctgcatt taaaagatac agttactcta
     6841 gtttgattaa attcttgcaa agtatccctt ctgtaaaatt tgtgatacaa tgctgtgccc
     6901 taaagtgtat ttttttacta atagtttatt atggcacatc agcacgattt ctgtttagat
     6961 aatacaccac tacattctgt taataatcat taggtgtgaa aggatttctt ttgtggttat
     7021 taaaaatctc aaatttctaa atctgcaaga ataaaacttt ttaaaataca
//
LOCUS       NM_001437444            1901 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 1, mRNA.
ACCESSION   NM_001437444 XM_006229014
VERSION     NM_001437444.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229014.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-729             JAXUCZ010000001.1  104572222-104572332
            730-1016            JAXUCZ010000001.1  104572931-104573217
            1017-1211           JAXUCZ010000001.1  104574234-104574428
            1212-1385           JAXUCZ010000001.1  104574810-104574983
            1386-1521           JAXUCZ010000001.1  104576616-104576751
            1522-1721           JAXUCZ010000001.1  104577665-104577864
            1722-1901           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1901
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1878
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 1 is encoded by transcript variant 1; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     1"
                     /protein_id="NP_001424373.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTN
                     VLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCS
                     GPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARW
                     HQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVER
                     SAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQ
                     QLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILPSPVSPAAPTLLSPGA
                     GAPGLGQTRQGRGPELHPSAGPRRSRSGQEPTADGQDEAGVRTEAEGMGGGEKVATLD
                     YMHLKMCSLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ"
     misc_feature    187..1875
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1875
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..729
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1016
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1211
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1385
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1721
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1901
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaaggg cccccgccct gatgttctga cccaggagaa ctgccgcaag
      661 gtgacccgtt cagtggaaga cgctgaaatc aaaaccaatg tcctgaagca gaactctgcc
      721 ttgttggagg agaagctaag atacctccag cagcaactgc aggatgagac gccccggaga
      781 caggaggccg agttgcagga gctggagcaa aaactagagg ctggcctctc ccggcatggc
      841 ctaggcccta ctactcccat tcagggctgc tccggtcctc ctggtagccc ggaggaaccc
      901 ccgcggccgc gaggcctgcc ctccaatggc tggggcatgg caatccgcgc aggggaggga
      961 ccctcgctga gcgagcagga gttgcagaag gtctccagcg gcctagagga gctgaggagg
     1021 gaggtgtcct cgctggcagc tcggtggcat caggaggagg gggcggtgca ggaggcccta
     1081 aggttgctgg gaggcctggg cggccgtctg gatggctttc tgggccaatg ggagcgggcg
     1141 cagcgggaac aagcacagtc cgcacggggt ttgcaggagc tgcgaggacg agcagatgag
     1201 ctgtgcacta tggtggagag gtcagcagtg tctgtcgctt cactgaggag cgaactggag
     1261 gcactgggcc cagtaaaacc gattctggag gagctgggac ggcaacttca aaactcccga
     1321 aggggacctg accatgtctt gaacttggat cgtcctgccc aaggtccctg tcctcgatgt
     1381 gccagccagg ggcagcagtt atccacggag tccctacagc agctgctgga acgtgcgctg
     1441 accccactgg tggacgaagt gaagcagaag ggtctggctc ctgcctgccc cagttgccag
     1501 aggctacaca agaagattct gcccagtcca gtaagcccag cggcgcctac actcctctcc
     1561 ccaggagctg gagcgccagg ccttggccaa acacgtcagg gcagaggccc tgagctccac
     1621 ccttcggctg gcccaagacg aagccgttcg ggccaagaac ctactgctga cggacaagat
     1681 gaagccggag tgaggacgga ggcagagggc atgggaggag gggagaaggt ggccactttg
     1741 gactatatgc atttgaagat gtgttccctc cacgaccaac tcagccacct gccacttgag
     1801 gggtccacag gggcaatggg gggaggaagc actggagggg ctccccctaa acgtgggggt
     1861 ccaggctctg aacaataaat ggcctctcat gctggcatga a
//
LOCUS       NM_138538               7455 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus dynamin 3 (Dnm3), transcript variant 1, mRNA.
ACCESSION   NM_138538
VERSION     NM_138538.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Li,J., Zhang,D.S., Ye,J.C., Li,C.M., Qi,M., Liang,D.D., Xu,X.R.,
            Xu,L., Liu,Y., Zhang,H., Zhang,Y.Y., Deng,F.F., Feng,J., Shi,D.,
            Chen,J.J., Li,L., Chen,G., Sun,Y.F., Peng,L.Y. and Chen,Y.H.
  TITLE     Dynamin-2 mediates heart failure by modulating Ca2+ -dependent
            cardiomyocyte apoptosis
  JOURNAL   Int J Cardiol 168 (3), 2109-2119 (2013)
   PUBMED   23410488
  REMARK    GeneRIF: DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic
            death of cardiomyocyte.
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Grossman,G.H., Ebke,L.A., Beight,C.D., Jang,G.F., Crabb,J.W. and
            Hagstrom,S.A.
  TITLE     Protein partners of dynamin-1 in the retina
  JOURNAL   Vis Neurosci 30 (4), 129-139 (2013)
   PUBMED   23746204
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Tanifuji,S., Funakoshi-Tago,M., Ueda,F., Kasahara,T. and Mochida,S.
  TITLE     Dynamin isoforms decode action potential firing for synaptic
            vesicle recycling
  JOURNAL   J Biol Chem 288 (26), 19050-19059 (2013)
   PUBMED   23687302
  REMARK    GeneRIF: dynamin isoforms select appropriate vesicle reuse pathways
            associated with specific neuronal firing patterns
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   Gray,N.W., Fourgeaud,L., Huang,B., Chen,J., Cao,H., Oswald,B.J.,
            Hemar,A. and McNiven,M.A.
  TITLE     Dynamin 3 is a component of the postsynapse, where it interacts
            with mGluR5 and Homer
  JOURNAL   Curr Biol 13 (6), 510-515 (2003)
   PUBMED   12646135
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Cook,T., Mesa,K. and Urrutia,R.
  TITLE     Three dynamin-encoding genes are differentially expressed in
            developing rat brain
  JOURNAL   J Neurochem 67 (3), 927-931 (1996)
   PUBMED   8752097
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Nakata,T., Takemura,R. and Hirokawa,N.
  TITLE     A novel member of the dynamin family of GTP-binding proteins is
            expressed specifically in the testis
  JOURNAL   J Cell Sci 105 (Pt 1), 1-5 (1993)
   PUBMED   8360266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 3, 2025 this sequence version replaced NM_138538.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000013.1  77371058-77371389   c
            333-406             JAXUCZ010000013.1  77297301-77297374   c
            407-556             JAXUCZ010000013.1  77240975-77241124   c
            557-760             JAXUCZ010000013.1  77239796-77239999   c
            761-859             JAXUCZ010000013.1  77215985-77216083   c
            860-1020            JAXUCZ010000013.1  77215253-77215413   c
            1021-1163           JAXUCZ010000013.1  77212750-77212892   c
            1164-1299           JAXUCZ010000013.1  77207732-77207867   c
            1300-1367           JAXUCZ010000013.1  77205597-77205664   c
            1368-1506           JAXUCZ010000013.1  77202373-77202511   c
            1507-1593           JAXUCZ010000013.1  77190691-77190777   c
            1594-1664           JAXUCZ010000013.1  77181775-77181845   c
            1665-1716           JAXUCZ010000013.1  77169168-77169219   c
            1717-1746           JAXUCZ010000013.1  77168277-77168306   c
            1747-1860           JAXUCZ010000013.1  77130509-77130622   c
            1861-1970           JAXUCZ010000013.1  77034331-77034440   c
            1971-2082           JAXUCZ010000013.1  76990952-76991063   c
            2083-2247           JAXUCZ010000013.1  76926535-76926699   c
            2248-2474           JAXUCZ010000013.1  76918517-76918743   c
            2475-2711           JAXUCZ010000013.1  76917749-76917985   c
            2712-7455           JAXUCZ010000013.1  76896827-76901570   c
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..7455
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="dynamin 3"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
     exon            1..332
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2781
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /EC_number="3.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-dynamin; dynamin, testicular; testicular dynamin"
                     /codon_start=1
                     /product="dynamin-3 isoform 1"
                     /protein_id="NP_612547.1"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIE
                     AETDRVTGMNKGISSVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKE
                     KKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKA
                     SLLRAGVYPDKSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIP
                     KTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALA
                     IIGDINTVTVSTPAPPPVDDSWLQHSRRSPPPSPTTQRRLTLSAPLPRPASSRGPAPA
                     IPSPGPHSGAPPVPFRPGPLPPFPNSSDSYGAPPQVPSRPTRAPPSVPSRRPPPSPTR
                     PTIIRPLESSLLD"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    361..369
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    862..864
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    874..885
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1066..1068
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P39054; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    1747..2076
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    1747..2076
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    order(1747..1749,1753..1758,1762..1764,1813..1815,
                     2020..2025,2032..2034,2041..2046,2053..2055)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    order(1747..1749,1753..1758,1762..1764,1813..1815,
                     2020..2025,2032..2034,2041..2046,2053..2055)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    1978..1980
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    1981..1983
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50570; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    2134..2406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2134..2406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2425..2778
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <2428..2694
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    <2428..2694
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    2476..2478
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    2488..2490
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    2728..2730
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     exon            333..406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..556
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..760
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..859
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1020
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1163
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1299
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1367
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1506
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1593
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1664
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1716
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1746
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1860
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1970
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2082
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2247
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2474
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2711
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..7455
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagctgtc aggagcctag cagcgggtgg cagggatcgg acgacggtgc cgggactcag
       61 cggtgtgagc cccgcgcatc aacaaaccgg acaagtgctg cgaggcccgg gctgcctgcc
      121 aggtcgctga gtcgcgcagg gacctgtggg gcagttggcc gcacaggcaa gatggggaac
      181 cgggagatgg aagaactgat ccctctggtg aaccgtctgc aggacgcttt ctcggctctg
      241 ggacagagct gtctgctgga gctgccacag atcgccgtgg tgggcggcca gagcgccggc
      301 aagagctcag tgctcgagaa cttcgtgggc agggactttc ttcctcgagg ctcgggcatt
      361 gtgaccagac gacctcttgt actccagctt gtcacctcta aagcagaata tgccgagttt
      421 ctacattgca aaggaaaaaa atttacagat tttgatgaag ttcgccacga gatcgaagca
      481 gaaacggacc gagtaacagg aatgaataaa ggcatctcct ctgtacccat taaccttcga
      541 gtctactctc cccacgtgtt aaacctaacg ctaatcgacc tacctggaat aacgaaagtg
      601 cccgtgggag accagccgcc agatattgag tatcagatca gagatatgat tatgcagttc
      661 atcaccaggg agaactgtct gattttggct gtcacaccag ccaacaccga tcttgcgaac
      721 tcagatgccc tgaagctagc caaagaagtc gatcctcaag gcctgaggac cattggcgtt
      781 atcaccaagc tggatctcat ggatgaaggg acggatgcca gggatgtact agagaacaag
      841 ctgctacctc tccgcagggg ctatgtgggg gtggtcaacc gaagccagaa ggacatagat
      901 ggaaagaagg acattaaggc agctatgctg gcagaaagga aattttttct ctctcatcca
      961 gcatatagac acattgctga tcggatgggg accccacacc tccagaaggt cctgaatcag
     1021 caacttacca accatatccg agataccctg cccaacttca ggaacaagct acaggggcag
     1081 ctgctctcca tagaacatga agtagaagcc ttcaaaaact tcaaaccgga agaccccaca
     1141 aggaagacca aagcactgct acagatggtc caacagttcg ctgtggactt tgagaagaga
     1201 atcgaagggt cgggggatca agtagacacg ttagagctct ctggcggtgc taagatcaat
     1261 cgcattttcc acgaacgctt tccttttgag atagtgaaga tggagttcaa tgagaaagaa
     1321 ctgagaagag aaataagcta tgcaatcaaa aacatacacg ggatcaggac agggttgttt
     1381 actccagaca tggcgtttga ggcaatagtc aaaaaacaga tagtaaaact gaaagggcct
     1441 tctttgaaga gtgtggacct ggtgatgcag gaactgatca acacggtgaa gaagtgcacc
     1501 aagaggctgg ccaacttccc cagactttgt gaagaaacag aaaggattgt tgctaaccac
     1561 atccgtgagc gagaaggaaa gaccaaggac caggtcctgc tactgattga cattcaagtc
     1621 tcttacatta acaccaacca tgaggacttc atcggctttg caaatgctca gcagagaagc
     1681 agtcaggttc acaagaaaag cacaattgga aatcagggaa ccaatcttcc gccttcaagg
     1741 caaattgtga ttcggaaggg ctggctgacc gtcagcaaca ttggcatcat gaaaggaggc
     1801 tcgaagggct actggtttgt cctcacggca gaaagcttgt cctggtataa agacgatgag
     1861 gagaaagaaa agaagtatat gcttccactg gacaacctga aagtccggga cgtggagaaa
     1921 ggcttcatgt ccagcaagca cgtcttcgca ctcttcaaca cagaacaaag gaatgtctac
     1981 aaagactatc gttccctgga gctggcctgt gattcccagg aggatgtgga cagctggaag
     2041 gcgtctctgc tcagagctgg cgtctatcca gacaagtctt ttactgaaaa tgatgaaaat
     2101 ggacaagcag aaaacttctc catggacccg cagttggaga ggcaagtgga gactattcgc
     2161 aacctcgtag actcctacat gtcgataatc aacaaatgca tccgagacct aattccaaaa
     2221 acaataatgc accttatgat caataatgtt aaagacttca tcaactctga actcctagca
     2281 cagctctact cctctgagga ccagaacaca ctaatggaag aatccgtgga gcaggctcag
     2341 cgccgggatg agatgctccg gatgtaccaa gccctgaaag aagccctcgc gatcattggc
     2401 gacatcaaca cggtcactgt gtccacccca gccccacctc cagtagatga ctcctggctc
     2461 cagcattcca gaaggtcacc tcctccaagc cccaccaccc aaagaaggct gactctaagt
     2521 gctcccctcc cgaggcccgc atctagccgt ggaccagctc ctgccattcc ctctccaggc
     2581 ccccactctg gggctccccc agtcccattc cgtccaggcc cattacctcc ttttcccaac
     2641 agcagtgact cctacggagc ccctccacag gttccatcca ggcccacaag ggcacccccc
     2701 agtgttccaa gccggaggcc acccccatca ccaactcgcc ccactataat ccgtccacta
     2761 gagtcctcac tgttagacta aacgaagtgt ccggcatggc aattaaatca ctaatgattc
     2821 atgcaaaagc agcattcggt tacctttgca gccaaccatg agtagtcgca tgtatggacc
     2881 tccataggca agtagccagt cctactaaca tgttcatcgc tcatcttcat tgctcatggt
     2941 gggttagacc ttagggtttg actctgaaaa cctgctcacc tgtagagagg cttaatatgt
     3001 tgtattgacc gaggtagttt tatagaacag tcctatactt tggtaccact tacctgtcca
     3061 acagatagca gaaattgctt tggaagagtt ttctaggctg tctacagagg agcttacgag
     3121 gcttccgaac agacacaaga gtgtgagctt ggaaccacac cgacttctcc cacattctgt
     3181 tttgggtggc agaaactctg ctgtctgata ttaatgccac cactcagtcc gcagttgctt
     3241 atttaggctt ctttccctcc ttatttcata agactgctaa aaataaataa ataaataaat
     3301 aaataaataa ataaataaat aaataaataa atggcaaggt ttttaaatca ggattgctta
     3361 aatcgggagc ctttcaggag cacgaggcag gctgtaaagg gagcgtctcc agggtttgct
     3421 ccggggagcg tctcctgtgc attttgcttc atgctagaag cacaagcaac atcaaggcaa
     3481 agctcgaggg atttttggtg atcggtggat aggtttgcct acttttagag ttcaaagaag
     3541 caaaagtaaa ttgccatttc taacagtgtc tggggaaata taatttatta tcttattatt
     3601 tacctctttg tgggctatga tgaaggaagg ttggcatttc cagttgattg ggggaggggc
     3661 atgggtaact aattccactt agttattatg attattattt tggctggaga aaagttaagt
     3721 gtatgctagc acatgatttc tatggtttac atataaatga ccatagaaga atccgtttca
     3781 aagtacttta atgtctctac ccattccaga ctctcttaaa tcttgcagct taccgtggca
     3841 ccattgcgtg gagagtgtgg cccctggtac gggaaggcaa ttcatcagag atgccatggt
     3901 ttaggagcac agctcctggg tttacagacg ccttgccacg gcttgctccc gaaaagcagc
     3961 cacactgagc tgcagaaaaa gtttgcaatt tctaagatct ctgaacttca cgagtgcagc
     4021 ctagcctaca ggtcattagt tcagtcttga ggctaagttt tgaactacct atgaccagat
     4081 ggttaacaga gcaaacagct agaggccaaa aggaattctg tctgctaact gcacccagac
     4141 tgcagagtgg gctgtcactg aattgcagca tcccgagaca gtattccata atcaaaaatc
     4201 aaatcaggtc ttactaacta cagcatctcc caatgacggc ggtcaacatg atttgtatgt
     4261 gaccttcact ttaatttcct gtgcagtttc tacccaaagc aaggggctat aaaaagtgtg
     4321 atgtaaagac gtttagccat tatttgaaaa agtcttcttt tttctaagtg aaaaatgtca
     4381 ctgcattgaa tttattctaa tgggttagat cccacttata attggcaaaa gttggagaac
     4441 atgagacgta caaaggggtg gttttcaacc tttaagttac acagaattac caatgctcta
     4501 ggttctctat aatttttccc tgttgaaaaa aaaagtattt gtgaatggta ctcatgtaag
     4561 acatgcacat tgtctttgaa aggtatccca gctaaatggg aaaacgttag gcaagcattt
     4621 ataattgaac aactcataga caatgaggct ctccacaaaa cccttccttt cagcactccc
     4681 ttttggcttc ttcctatgag ttctctaaaa caggcagcta atgaactaga tacttcaggg
     4741 cttggcttcg ttcttcctgt ggttttgcat cttgctatat ttcaaatttt tcgttcgttg
     4801 gaggaaacta ttgcagaaaa ccactggtgt gttctcaaat cagcacaggc caatgtcaag
     4861 gaaaactggg gatttgtctc tccaaacttc ttcccactga tcctagacgg taaacgatgg
     4921 cgcttgtcat ctttagcttt tgcttcttgg tccacagatt ccctgtccca aatgtgtccc
     4981 tttgtcagga cagtttcgtc ctgctggcta ccgtgttaca tctggtggaa gccagaatcc
     5041 cctactctac cacccccctc cccagaaggc caaccctggc acctcagaat aatttcagac
     5101 ggctgcgatt caaagggtct gcactctgct aacaggaagc accaacatga gcgaagcctg
     5161 aagtttcact ggagtgtgca ccgtgcacat caggcctggt gatgggaatg gaagctccaa
     5221 gggcctcctg cttcccactc cgtttctgat ctctcagtca gccctcctgg ttgatgaccc
     5281 cagtgttgtc agcacaacag gtgtagcttt atcttgtcta gcataattaa taactttaaa
     5341 aagtgctttc gggatgtgaa aaggtaactg tacgtgtttg ataagccaat gttcctgtct
     5401 cgtgctaaac tctgcatgca gactggttaa ccggaataac cagccatcag tggacggacc
     5461 atgaaacagt atttagaaca gatgtatttc caaaaagcat ctaccaagaa taccttcttg
     5521 aatatttgcc tttagtgtgt cttattacac agaagagcag tggggtctac ttattggcaa
     5581 tttctctgtt tgtgcagata catactcatt ctatccaaaa gcgtaacgaa cagttcctgt
     5641 gacgtcagca ttctagattt agagttaagg agtagccaca tagattcgtt cgtgatttct
     5701 ttagactgta gccatactct aagctatgaa gtgggacctg acacccgtat gtgacaagtg
     5761 tttgctgtcc aactcgtttt ctctgcatgt ccctaagaat acactacata tacagtgacc
     5821 acgtgtttcg tgtcctttta agtaagtagg ttcaaaagca cttactaaaa tgccattaag
     5881 catgattgtg attttatgta catcatatat atatgaatat aaatatcagt gtaaacctgt
     5941 gctcagtatg taagagtatg aatatatttt taactgtgct aatatgtatg ttgggaagac
     6001 ttgccataac atgattacgg tagttcattt ctcatgacct ccgtgagaaa cagaagctct
     6061 cctaactcat actgtatata ttctgagggg cacaaagctt acgataaccc tgatgatcac
     6121 catacttata gccatgacaa ggcaatgtct acggtccttt gtattgaaac ccacagcact
     6181 gctgcctaag aaggcattac ttttggggtg atactttgat aaaaaaaagt ataagatttg
     6241 ggagcttttc tccagggtct ctagttagaa tggtgttatt tgggaattgt tgagctgacg
     6301 ctttaaaaaa aaaaaaaaag gttaaatgag atctctttag taaaggttaa aagaatacag
     6361 agtcagcaaa actattaaag catgaggggg acaggatact caattccttg caggtatcta
     6421 ctctgtcagg taaaccttgt acatttggaa aacagtacaa ttacatcgat gggactctct
     6481 gtaggatgag tggcaaaacc taaacagacc tcctaactgt cttaatccag caagaggtga
     6541 ctgcatgtaa gacagaagca tgagcgctat cacttcacct cgcactaacc tgtggactag
     6601 agttcctgtg agtgaagcca attttagaga aataacggat agttcgccag atcctttagt
     6661 cttttctaaa gaactcagct tgtctcctag ataacaatag gtcgtctgtc tagctgatgt
     6721 gtttaaaatt acgtggtgct ctgtgtgtga aattttaaca atatttttga agcatatata
     6781 gtatatgcat cgctagttgt gtatatatgc atacatgtaa taatatctgt atgtgtggag
     6841 agcaagagac aggaacctca gagaacctcc tgtttaaggc ctgtcagcac tggtacactg
     6901 gtgagactcc tctttccact gctcaaggac tacatgtggc tcaactcaag gcattcattt
     6961 ccttataact tttaccttta agtcccttaa actttaactc ataatgtttt cgatttatac
     7021 aaaaaccact cccgtcttgt actgaccgct gccaatctgt gaaaacacct cacaaaccag
     7081 aaaccctacc accatagccc tgtgtgtttg atttcatata cgcactgctt ttgttccatg
     7141 ggcttgtacg tgttcctcct ctctccccgt tctgagtcaa acttcatttc gctttcgtgt
     7201 gaatgactga gtacatagaa gtcaaacctt gttttctccg ttgattcttt aacatgaacc
     7261 agaatacttc ccactgtcgt ttttaccact ttggggattt cttaatgctg gattaatatg
     7321 gattctgtga atgggatttt tttgaagcaa attcctaaaa gcctgtatca tccttgaagg
     7381 tcatgtacct attgtgaaaa aaaaaatgtg aaactgtatt tctgaacctg aaataaatga
     7441 ttacatttga aggaa
//
LOCUS       NM_001437460            1161 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus nitric oxide synthase interacting protein
            (Nosip), transcript variant 2, mRNA.
ACCESSION   NM_001437460 XM_063284172
VERSION     NM_001437460.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Yu,X., Zhong,Y., Zhu,Z., Wu,T., Shen,A. and Huang,Y.
  TITLE     Increased expression of nitric oxide synthase interacting protein
            (NOSIP) following traumatic spinal cord injury in rats
  JOURNAL   J Mol Histol 43 (6), 661-668 (2012)
   PUBMED   23135205
  REMARK    GeneRIF: Data suggested that NOSIP may play an important roles in
            astrogliogenesis after a spinal cord injury.
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Dreyer,J., Schleicher,M., Tappe,A., Schilling,K., Kuner,T.,
            Kusumawidijaja,G., Muller-Esterl,W., Oess,S. and Kuner,R.
  TITLE     Nitric oxide synthase (NOS)-interacting protein interacts with
            neuronal NOS and regulates its distribution and activity
  JOURNAL   J Neurosci 24 (46), 10454-10465 (2004)
   PUBMED   15548660
REFERENCE   4  (bases 1 to 1161)
  AUTHORS   Dedio,J., Konig,P., Wohlfart,P., Schroeder,C., Kummer,W. and
            Muller-Esterl,W.
  TITLE     NOSIP, a novel modulator of endothelial nitric oxide synthase
            activity
  JOURNAL   FASEB J 15 (1), 79-89 (2001)
   PUBMED   11149895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284172.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3041.1,
                                           SRR26643286.1537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  104679882-104679922
            42-120              JAXUCZ010000001.1  104688756-104688834
            121-292             JAXUCZ010000001.1  104691442-104691613
            293-398             JAXUCZ010000001.1  104692002-104692107
            399-480             JAXUCZ010000001.1  104692637-104692718
            481-640             JAXUCZ010000001.1  104693880-104694039
            641-759             JAXUCZ010000001.1  104694121-104694239
            760-947             JAXUCZ010000001.1  104694338-104694525
            948-1056            JAXUCZ010000001.1  104694601-104694709
            1057-1161           JAXUCZ010000001.1  104695015-104695119
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1161
                     /gene="Nosip"
                     /note="nitric oxide synthase interacting protein"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
     exon            1..41
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            42..120
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            121..292
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Nosip"
                     /note="upstream in-frame stop codon"
     CDS             223..1128
                     /gene="Nosip"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="nitric oxide synthase-interacting protein"
                     /protein_id="NP_001424389.1"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
                     /translation="MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFD
                     CCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQMKAYEKQRGARREEQKEL
                     QRAAAQDQVRGFLEKESAIVSRPLNPFMPKAATLPNTDGEQPGPSVGPLGKDKDKALP
                     SFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRS
                     ERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVL
                     QRGGTGFAGSGVKLQAEMSRPVMQA"
     misc_feature    232..456
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    232..456
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    880..1083
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     misc_feature    880..1083
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     exon            293..398
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            399..480
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            481..640
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            641..759
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            760..947
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1056
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1161
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagttga agcaacgaca ggacggatag tcgtttttga gagataacat ttctcagctg
       61 gaggtggcta gctcagctgg cccttgcttg gtggcagtca caggaagccc tgcggtgaag
      121 gcgagttcaa aaggcttctg gagcaggcta ctgaccacaa gcccaggagg tgttcgtgtc
      181 ctgtgtgagt gaggtcaccc tgccacttcc cccttggaca agatgacaag gcatggcaag
      241 aactgcactg caggggctgt ctacacctac cacgaaaaga agaaggacac agcggcctca
      301 ggctatggga cccagaacat tcgactgagc cgggatgctg tgaaggactt tgactgctgc
      361 tgtctctctc tgcagccctg ccatgaccct gtggtcaccc cagacggcta cctgtatgaa
      421 agggaggcaa tcctggagta catcctacac cagaagagag agattgcccg gcagatgaag
      481 gcctatgaga agcagcgagg agcccggaga gaagagcaga aagagctgca gcgagctgca
      541 gcacaggacc aagttcgagg cttcctggag aaggagtcag ccattgtgag ccggcccctc
      601 aaccccttca tgcccaaggc tgccaccttg cccaacacag atggtgaaca gccagggccc
      661 agtgtgggtc ccctaggcaa ggacaaggac aaagcactac ccagcttctg gattccctca
      721 ctaacgcccg aggcaaaggc caccaagctg gaaaagccgt cccgcacggt gacctgcccg
      781 atgtctggga agccactgcg catgtcggac ctgacgtcag tgcgcttcac acagctggac
      841 gactctgtgg accgagtggg gctcatcacg cgcagtgagc gctacgtgtg cgcagtgacc
      901 cgagacagcc tgagcaacgc cacgccgtgt gcggtgctgc ggccctccgg ggctgtggtc
      961 accctggagt gtgtggagaa actgatccgg aaggacatgg tggaccccgt gaacggagat
     1021 acgctgacgg agcgggacat catcgtgctg cagcggggtg gcacaggctt tgcaggctcc
     1081 ggagtgaagc tacaggcaga aatgtcccgg ccagtgatgc aggcctgagc cgtgacctaa
     1141 taaacttgga cgtgaacagg c
//
LOCUS       NM_001437452            1750 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 10, mRNA.
ACCESSION   NM_001437452 XM_063284135
VERSION     NM_001437452.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284135.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1155523.1,
                                           SRR26360181.2546591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-653             JAXUCZ010000001.1  104572222-104572332
            654-940             JAXUCZ010000001.1  104572931-104573217
            941-1135            JAXUCZ010000001.1  104574234-104574428
            1136-1309           JAXUCZ010000001.1  104574810-104574983
            1310-1445           JAXUCZ010000001.1  104576616-104576751
            1446-1570           JAXUCZ010000001.1  104577708-104577832
            1571-1750           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1750
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1727
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 10 is encoded by transcript variant 10;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     10"
                     /protein_id="NP_001424381.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KGPRPDVLTQENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEA
                     ELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGP
                     SLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWER
                     AQREQAQSARGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQ
                     NSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPA
                     CPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPEEKVA
                     TLDYMHLKMCSLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ"
     misc_feature    135..1724
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..1724
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>743
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>743
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..653
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..940
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1135
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1309
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1445
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1570
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1750
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 agggcccccg ccctgatgtt ctgacccagg agaactgccg caaggtgacc cgttcagtgg
      601 aagacgctga aatcaaaacc aatgtcctga agcagaactc tgccttgttg gaggagaagc
      661 taagatacct ccagcagcaa ctgcaggatg agacgccccg gagacaggag gccgagttgc
      721 aggagctgga gcaaaaacta gaggctggcc tctcccggca tggcctaggc cctactactc
      781 ccattcaggg ctgctccggt cctcctggta gcccggagga acccccgcgg ccgcgaggcc
      841 tgccctccaa tggctggggc atggcaatcc gcgcagggga gggaccctcg ctgagcgagc
      901 aggagttgca gaaggtctcc agcggcctag aggagctgag gagggaggtg tcctcgctgg
      961 cagctcggtg gcatcaggag gagggggcgg tgcaggaggc cctaaggttg ctgggaggcc
     1021 tgggcggccg tctggatggc tttctgggcc aatgggagcg ggcgcagcgg gaacaagcac
     1081 agtccgcacg gggtttgcag gagctgcgag gacgagcaga tgagctgtgc actatggtgg
     1141 agaggtcagc agtgtctgtc gcttcactga ggagcgaact ggaggcactg ggcccagtaa
     1201 aaccgattct ggaggagctg ggacggcaac ttcaaaactc ccgaagggga cctgaccatg
     1261 tcttgaactt ggatcgtcct gcccaaggtc cctgtcctcg atgtgccagc caggggcagc
     1321 agttatccac ggagtcccta cagcagctgc tggaacgtgc gctgacccca ctggtggacg
     1381 aagtgaagca gaagggtctg gctcctgcct gccccagttg ccagaggcta cacaagaaga
     1441 ttctggagct ggagcgccag gccttggcca aacacgtcag ggcagaggcc ctgagctcca
     1501 cccttcggct ggcccaagac gaagccgttc gggccaagaa cctactgctg acggacaaga
     1561 tgaagccgga ggagaaggtg gccactttgg actatatgca tttgaagatg tgttccctcc
     1621 acgaccaact cagccacctg ccacttgagg ggtccacagg ggcaatgggg ggaggaagca
     1681 ctggaggggc tccccctaaa cgtgggggtc caggctctga acaataaatg gcctctcatg
     1741 ctggcatgaa
//
LOCUS       NM_001437484            7532 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 655 (Zfp655), transcript
            variant 3, mRNA.
ACCESSION   NM_001437484 XM_006248895
VERSION     NM_001437484.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7532)
  AUTHORS   Houlard,M., Romero-Portillo,F., Germani,A., Depaux,A.,
            Regnier-Ricard,F., Gisselbrecht,S. and Varin-Blank,N.
  TITLE     Characterization of VIK-1: a new Vav-interacting Kruppel-like
            protein
  JOURNAL   Oncogene 24 (1), 28-38 (2005)
   PUBMED   15558030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006248895.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.42338.1,
                                           SRR26643299.49489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000012.1  14488258-14488345   c
            89-251              JAXUCZ010000012.1  14486463-14486625   c
            252-356             JAXUCZ010000012.1  14475787-14475891   c
            357-7532            JAXUCZ010000012.1  14467958-14475133   c
FEATURES             Location/Qualifiers
     source          1..7532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..7532
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="zinc finger protein 655"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
     exon            1..88
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            89..251
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="upstream in-frame stop codon"
     CDS             116..1741
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="isoform 2 is encoded by transcript variant 3; vav-1
                     interacting Kruppel-like protein; zinc finger protein
                     205-like"
                     /codon_start=1
                     /product="zinc finger protein 655 isoform 2"
                     /protein_id="NP_001424413.1"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
                     /translation="MEEITSQEAAESPRVQFQSLESQSECLSPELRFLRDTEMEQGYT
                     DGFPISKPDGISQREQDLQVFDLETQNREGVRNDCSDGETREENKLLIPKRKISEEVH
                     SYKVRVGKFKQDIAQVPETREAYKSEDRLERLQEILRKFLFLEREFRQITISKKTFSN
                     EKNTEPEKSFSLDSTLDTDQRVLRIQTIDDSKYDMNFNQNPAVGEQEPINLTENFQNT
                     DYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKCKEC
                     EKSFSQSSSLSRHKRIHTREKSYRCEASDKSCDASDKSCSQSSDVLQHKKVHAKAKSY
                     KCGTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTSYLVEHQRLHHQEKSYEYD
                     ECGLAYVKQQGIRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEKLHECNERGKAFSQ
                     TSCLSQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVFDCDAWEENFSQRA
                     HLIPHERAHTKEKPYECNELGETFSQVQASFNM"
     misc_feature    824..>1696
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    824..>1696
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    848..910
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    848..910
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(863..865,869..871,875..877,881..886,893..898,
                     905..907,1052..1054,1058..1060,1070..1075,1082..1087,
                     1094..1096,1136..1138,1142..1144,1148..1150,1154..1159,
                     1166..1171,1178..1180)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(863..865,869..871,875..877,881..886,893..898,
                     905..907,1052..1054,1058..1060,1070..1075,1082..1087,
                     1094..1096,1136..1138,1142..1144,1148..1150,1154..1159,
                     1166..1171,1178..1180)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    932..1099
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    932..1099
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    944..994
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    944..994
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1121..1183
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1121..1183
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1202..1264
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1202..1264
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1217..1219,1223..1225,1229..1231,1235..1240,
                     1247..1252,1259..1261,1367..1369,1373..1375,1385..1390,
                     1397..1402,1409..1411,1451..1453,1457..1459,1463..1465,
                     1469..1474,1481..1486,1493..1495)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1217..1219,1223..1225,1229..1231,1235..1240,
                     1247..1252,1259..1261,1367..1369,1373..1375,1385..1390,
                     1397..1402,1409..1411,1451..1453,1457..1459,1463..1465,
                     1469..1474,1481..1486,1493..1495)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1352..1414
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1352..1414
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1436..1498
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1436..1498
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1604..1666
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1604..1666
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            252..356
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            357..7532
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcgagagt ggccccggaa aggctggtga gactcagcga ggagcgtctc cgtgacggga
       61 cagtctctag gcccgcctct ccacctggtg atggtcattg tctccctgaa cagggatgga
      121 ggaaataaca tcccaagaag cagcagaatc accaagggtc cagtttcagt ctttggagag
      181 ccagtctgaa tgtctttccc cagagcttcg gtttctgcgg gacacagaga tggagcaggg
      241 atacactgat ggatttccaa tttccaagcc tgatggaatt tctcagcggg aacaagatct
      301 acaagtcttt gatctggaaa ctcagaatag agaaggcgta agaaatgact gttcagatgg
      361 agagaccaga gaagaaaaca agctgttgat tcctaagcgg aaaatttcag aagaagtaca
      421 ttcatacaaa gtgagagtag gaaaattcaa acaagatatt gctcaagttc ctgagaccag
      481 agaggcttat aagtctgagg acagattaga aaggctccag gagattctaa gaaaatttct
      541 ctttctggag agagagttta gacaaataac aatcagcaag aaaactttca gcaatgagaa
      601 gaacactgaa cctgaaaaaa gcttcagtct agactccaca cttgatacag atcaaagagt
      661 tcttagaata cagaccattg atgacagtaa atatgacatg aacttcaacc agaacccagc
      721 tgttggcgaa caagaaccca taaatctaac agagaatttt cagaatactg actataagga
      781 aagcttaatg gatctgtccc accttaataa atgggagagc atgcctacca ctgacagatc
      841 ctataaatgt gatacatgtg gaaaaacctt ccatcaggcc tcagctctta ctagacatca
      901 gagaatccac acaagagaga aaccctacaa atgtaaggaa tgtgagaaat cttttagtca
      961 gagctcaagt cttagtcgac ataaaagaat acacactaga gagaaatcct acagatgtga
     1021 agcatctgat aaatcttgtg atgcctctga taagtcttgt agccagagct cagatgtgct
     1081 tcagcataag aaggttcatg ccaaagccaa gtcttacaag tgtgggacct gtgaaagagt
     1141 cttcagccga agtgtgcatc ttactcagca tcagagaaca cataaggaca cggcctgtaa
     1201 atgcactgtg tgtggcagtg acttctgcca cacctcatac ttagttgaac atcagagact
     1261 acatcatcaa gagaagtcct atgaatatga tgaatgtggg ctggcctatg ttaaacagca
     1321 aggaattcgt ttccgagaaa agccctactc gtgtaatgaa tgtgggaaag actttagatt
     1381 gaattcccat cttgttcagc atcaaagaat tcacacagga gaaaaactgc atgaatgtaa
     1441 tgagcgtggg aaagctttca gccagacctc ctgccttagt cagcatcata aaatgcacag
     1501 gaaagagaaa tcatacgaat acaacaatta tgaggaaagt ttcagtcaca attctgatct
     1561 tactctgcaa caagaagttc ccattagaga gagagtcttt gattgtgatg catgggaaga
     1621 gaacttcagt cagagagcgc acctcatccc acatgaaagg gcgcatacca aagagaaacc
     1681 ttatgaatgc aatgaacttg gggagacgtt tagtcaagtt caggcctcat tcaatatgtg
     1741 agaactgaga ccaggggaag tcacatatgt actgaatgtg ataatgtctt cagtcatagc
     1801 ttagcccttg gtcagtatca gagaattaat accagagaga aacccgctga atgtgatgaa
     1861 tattgggaag tttttttggt gttaaattct tcattggctc ctgtaaatca gtgctagaat
     1921 atatagacta tggtacattc ttcagattat tttcatacct tagtcacagt tggggaattt
     1981 gtactggagt aaaattccac tgtcaaatgt gaaaaagcca tcagtcaact accttgttgg
     2041 ttcagtgtca aatttgtgcc atgcataaag cctgtgagga tataggtgtg tatgtgagga
     2101 aactcaagtc ataccccagt gcttgctcac attgaagaat ctaaaccctt gaacagtcta
     2161 tacccaagaa gtcatttggg tgtagtaaat gtggcatatc tgtgagcacg ggtccatcta
     2221 ttgtcagaat gtaccagatg tgaatctgga tatgatgtaa atgctaagat cagaacatct
     2281 gcaccagatg agactgatag aatgcaaaca gtgaaattta accactgtat tttcaggcct
     2341 tatccagtat ctcaaagtat tagaaaatgg ttactgctct gtataattat tcctatttag
     2401 tctcagtctt tttactgcag aataactgaa cccagaagat aattggtgaa cgaagtcatt
     2461 ttctcacagt atcctttaat aagtattcta agtaggtacg agtattttat ttacaggact
     2521 cctttgagtg gatttatttt aattcggcct acatacatta aaacacttct tttctttgaa
     2581 atcgattctt gttcacagtt tacgtaggat gctgctaatg cgctgtgctc acttagcttc
     2641 tggagaggag ctcaatgagc cttctctgtt cttggcctga gtgctctcca aaggagactc
     2701 agcctattct tttctgagga ccctacatgt tactgtttct gtagccacac cttgggcttc
     2761 cagttgattt ctgcattctc cttggcagcc ttaaatggtg ttctggttgt tagcttctca
     2821 ccagctgata aagacttact tctacatcag ccatccataa gttttggagg attcagtctt
     2881 cctgagtttg tggcaggcac ccaaacactt gcaagtgatg tccaattttt agcttgtttg
     2941 catccacagc cctttaaatg agatgacaag gacatcaggg agccagtaag acttatgttg
     3001 gcctagctac atttcattca gtgcctactt tgcatgtatg tgtatgttta gaattctttt
     3061 atatgcctat attgaaggcc aacaaaatgc tcaggtctgc ttttgatagg gaaacaaaga
     3121 acacacaaat cagaataagg aaatagagcc ttccaatgaa gatgttgctg ttagtgatgt
     3181 atctagacag tatttcaaga gcgtggcagg tccgttcctg gtcaaacctt aatcattagg
     3241 attgcttctt tatctgttcc ccctctactc ccttcatcaa gccagggtag tattttgaag
     3301 tgtagacctt tgtgcataat tgtttgtgca ctgccatact tttgtgttgg gatgcagcct
     3361 ttgccgccca ggctggcctt gaattcctgg gttcacacaa atttcctgcc tcccaagtag
     3421 ctgggattat aggcatgcgc tcctgtgcct ggattttatt tttgtatttt aatagcatct
     3481 gcaggccatt taaaggatca tgtctatttt gatttataga agtgatcaca ggtgttgagt
     3541 tcagtgccct atatactaca tagagttcat gattctttac atgatgtcaa agcatttgtt
     3601 ttcatcttaa aataacatct tgtgaataag aaaagtgtta tttaaaattc tagttgtcaa
     3661 tcaagcagtt gaggctttca tagttcagat gtcataatgt tcactaggga tcctcaacca
     3721 atatataaaa tatgctgctc actctgtaaa ccttgtggct aacctaggat agggatagtc
     3781 ctaccactgt attttacttc tttgccatca gcaagcatag tgtctcatca gggcaagaaa
     3841 attaacatat atcaaattga tctaaatgta aaagcaaatg aaaaatgcat gtttttctgt
     3901 ccctgtcaaa catgtatact cttactttat agcgaccaat agtcacttct ggtgactgag
     3961 gcagaggatt tgattcatcc ctaagtagca gaatctgtaa aaatcacatg tatgcatttg
     4021 ggttaggaac gtgcttttgt atttctactt gaataaaggt gtgttcagcg ctcttagact
     4081 ctttgttttg aaccaagtct gtaggcccca ggcagaagct ctggcacctt ggaattcttc
     4141 accgtgcctg tccctagctc ctttatgata ctcacaagag tgattcgttc tctattgatg
     4201 cctagcttcc ctttccacag acctctgcag ccagttaggt tgagtagttt tgtattttag
     4261 atttaattaa aatgtttatg aatgtttgcc tgcatgtgca tgtgtgtctg gcattcatag
     4321 aagacagaag aggacatcag gtcccctgaa actggagtta gagagacatt tgagtgggtt
     4381 ctgaaatcac tgctgttctc tgcaagagca ggcagtgttc ttaactgcgg aaccaactct
     4441 caagccccag gaatgaatgt tggttcaggt gggatgcttt agtacataaa ataaaatcaa
     4501 acaatgtgtg atttcaataa cgctctaaga atgttttggt aggtaaagta aattttaaaa
     4561 aagaatgcca aaatcgtttt tgaagtaact tgtcagttta agtagatact tagttggtgt
     4621 agtgacagta tgagtttgta ttaattaagc ttttggtctt aggggaggaa aagaagaaat
     4681 ctattagctg gacagttagt tcatttgtct tcattaacct gtgtgcatac tttcacgtac
     4741 acattcaagc tttcaccaca gttctgcatg agagcttggc ttcgcaaaag gctaaagggt
     4801 tttagaacaa gttaatgtct gatgaaaact gattaatggc cgattcccag gtgacagggt
     4861 ttttggaagc ttttcctacg gtatcagtac tgttagcttc agctgatcat actggcttcc
     4921 agagctgatg tcagagttgg tttgatttgg tttgagaccg gacatctctg tatatatccc
     4981 tgactgttct ggaaccggct atgtagacca ggctgtagtt cacctgcctc ctaagtgtca
     5041 ccaccaccca gcagaagaga gtatcttaaa gtaatccgtg gacttagggt aacactgatg
     5101 taatgagtta acaggtcaaa ccctcagatt ttctatctcc tgcccagata tccctgcccc
     5161 atcattagtt tccctgttca tttctcagca ttctaaatta attcttagct ttttctgtta
     5221 gccaaactag ctgatggaca tagagctctt gacctgaagc aaaataaata acaggaagaa
     5281 gcaagcttga ttcctggggc atgtgaaaga aagacttaaa atgtagggag ccctggaaga
     5341 gtgttagaag aggtagagtg tccagtgctt atgaccgtct tggttagtgt tctaatttag
     5401 agaagaaaat gtttaactgg aggcttgctt acaatttcag aggataagtt catgatcatc
     5461 atggccggga acatggctgc cggtaagacc aggcatgtaa ctgagagctt atatcctgat
     5521 cttcaggcag gaggcagagg aattgagctg aaaatgtgct tttaaagtct caaaactcac
     5581 tcccttccct cagtgagata ccgccaacaa ggcctcatta gaatcttccc taaactgtct
     5641 acaatcaacc aaacaatcag atatgtgagc cctacgggcc attctcattc aaaccaccac
     5701 actgaaaaca ggattttttt tttttttttt tttttttttt tttaaagaca aggtttcact
     5761 ttactgcctt ggctggcctg gaactgtgat atgcccaccc ttgtctccta agtgttggga
     5821 ttaaaggcaa ggttctttat gtgtgagtga gtgagtgcct gcatgatgtc tgtgcgtcat
     5881 gtgcatgcaa tgtttgtgga ggactagatg gtgttggagt tcctagagtt actagtcaat
     5941 tgtgaattgc catggtcctg tgaattgaat gttcattttt taaatatttt ttttattcct
     6001 tgaaaatttc acacatatga tgctttgaca acatgaccat tttgtaagca atactaggtt
     6061 cttgggccta tgacctccct tactgtgaac aagtttgcag tagtaggcat aaattcacat
     6121 gaagcagcct cagatctaac cagaaagtgg caagagtata gcattttaaa gtgggaataa
     6181 ggggaatctc gaggggaaga atccttaccc tagaaaatgg atgtaagcag ttgaacaccc
     6241 tgggtctcca taccaagctt cattaggcaa atgctatact actaagctac atttccatcc
     6301 ccacctaggt ctatggtagt taaaaggagg ccccagttag tcacttcagc aaagtatgac
     6361 actgacacgt ctaaaaatgt agctccaccc atcggactta cctagttgtt aggtgtgtgg
     6421 tattggtgct agccagagtg acaaactgat ctaaaattaa tccatagatt taagaggact
     6481 gcgttattaa tgcagtgctt tggaagtaga catacttagg ttttgctcaa ctcaagtgtc
     6541 acttgaggtt ttatataact tgcctatgca ataaaagcat agtgaaaggt gaatgtaggg
     6601 gttggggatt tagctcagtg gtagagcgct tgcctagaaa gcgcaaggcc ctgggttcgg
     6661 tccccagctc cggggggggg ggggggggga agaaccaaaa aaaaaaaaaa aaaaaaggtg
     6721 aatgtaaaag gtaccagtca atagcaaatg ctcagttagt tcaggggcca gtgaagtggt
     6781 tcactaggta aggatgcttg ctgccaagcc tggtgatctt aatttcatca ctgggttcta
     6841 caagtaaccc tttaaccccc acattcttgc aatgcacagc acaccaaaat acgaattttt
     6901 aaaattttac attttaaaaa gtggtgcttg gaagatggca taagtgatta agagcatttc
     6961 tttccaggtt cagagcctgg gaaggctgac ttccatggtc agtgcacaca tgtgatacat
     7021 ataggcaata caccatatgc ataaattaaa tctttttgtt ggtttttgtc caagacaggg
     7081 tcttaatatt agctctggct gtcctggcac tcacagtgta gatcagggag gcctcaaact
     7141 ctcaagtgct gagattaaac gtgtactaca cacagcaaga actgagttta aggggctgga
     7201 gagatggttc agcccttaag agtgctgact gctcttccag aggtcctgag ttcaattccc
     7261 agcaaccaca tggtggctca caaccatctg taatgaggtc tgatgccctc ttctggcctg
     7321 taggcgtaca tgcaggcaga aagctgtatg ttgtatacat aatatttttt tttgtttttt
     7381 gttttttttt ggtttttttt tttttttttc ggagctgggg accgaaccca gggccttgcg
     7441 cttcctaggt aagcgctcta ccactgagct aaatccccag ccccatattg tttttaaaaa
     7501 aaaaaaaaaa gaactgagtt taagtcccag ca
//
LOCUS       NM_199088               1826 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 3, mRNA.
ACCESSION   NM_199088 XM_214920
VERSION     NM_199088.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1826)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1826)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1826)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1826)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced NM_199088.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY346104.1, SRR26360181.1919480.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-729             JAXUCZ010000001.1  104572222-104572332
            730-1016            JAXUCZ010000001.1  104572931-104573217
            1017-1211           JAXUCZ010000001.1  104574234-104574428
            1212-1385           JAXUCZ010000001.1  104574810-104574983
            1386-1521           JAXUCZ010000001.1  104576616-104576751
            1522-1646           JAXUCZ010000001.1  104577708-104577832
            1647-1826           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1826
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1803
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 3 is encoded by transcript variant 3; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     3"
                     /protein_id="NP_954519.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTN
                     VLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCS
                     GPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARW
                     HQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVER
                     SAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQ
                     QLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEAL
                     SSTLRLAQDEAVRAKNLLLTDKMKPEEKVATLDYMHLKMCSLHDQLSHLPLEGSTGAM
                     GGGSTGGAPPKRGGPGSEQ"
     misc_feature    187..1800
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1800
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    715..717
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    829..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    886..888
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    970..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    1720..1800
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..729
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1016
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1211
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1385
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1646
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1826
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaaggg cccccgccct gatgttctga cccaggagaa ctgccgcaag
      661 gtgacccgtt cagtggaaga cgctgaaatc aaaaccaatg tcctgaagca gaactctgcc
      721 ttgttggagg agaagctaag atacctccag cagcaactgc aggatgagac gccccggaga
      781 caggaggccg agttgcagga gctggagcaa aaactagagg ctggcctctc ccggcatggc
      841 ctaggcccta ctactcccat tcagggctgc tccggtcctc ctggtagccc ggaggaaccc
      901 ccgcggccgc gaggcctgcc ctccaatggc tggggcatgg caatccgcgc aggggaggga
      961 ccctcgctga gcgagcagga gttgcagaag gtctccagcg gcctagagga gctgaggagg
     1021 gaggtgtcct cgctggcagc tcggtggcat caggaggagg gggcggtgca ggaggcccta
     1081 aggttgctgg gaggcctggg cggccgtctg gatggctttc tgggccaatg ggagcgggcg
     1141 cagcgggaac aagcacagtc cgcacggggt ttgcaggagc tgcgaggacg agcagatgag
     1201 ctgtgcacta tggtggagag gtcagcagtg tctgtcgctt cactgaggag cgaactggag
     1261 gcactgggcc cagtaaaacc gattctggag gagctgggac ggcaacttca aaactcccga
     1321 aggggacctg accatgtctt gaacttggat cgtcctgccc aaggtccctg tcctcgatgt
     1381 gccagccagg ggcagcagtt atccacggag tccctacagc agctgctgga acgtgcgctg
     1441 accccactgg tggacgaagt gaagcagaag ggtctggctc ctgcctgccc cagttgccag
     1501 aggctacaca agaagattct ggagctggag cgccaggcct tggccaaaca cgtcagggca
     1561 gaggccctga gctccaccct tcggctggcc caagacgaag ccgttcgggc caagaaccta
     1621 ctgctgacgg acaagatgaa gccggaggag aaggtggcca ctttggacta tatgcatttg
     1681 aagatgtgtt ccctccacga ccaactcagc cacctgccac ttgaggggtc cacaggggca
     1741 atggggggag gaagcactgg aggggctccc cctaaacgtg ggggtccagg ctctgaacaa
     1801 taaatggcct ctcatgctgg catgaa
//
LOCUS       NM_001437532            3091 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 7, mRNA.
ACCESSION   NM_001437532 XM_006254639
VERSION     NM_001437532.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254639.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37625.1,
                                           SRR26643285.52071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000018.1  30382855-30382961
            108-277             JAXUCZ010000018.1  30385958-30386127
            278-439             JAXUCZ010000018.1  30386679-30386840
            440-591             JAXUCZ010000018.1  30387819-30387970
            592-700             JAXUCZ010000018.1  30394196-30394304
            701-1243            JAXUCZ010000018.1  30394747-30395289
            1244-1472           JAXUCZ010000018.1  30396391-30396619
            1473-1645           JAXUCZ010000018.1  30399772-30399944
            1646-1776           JAXUCZ010000018.1  30401686-30401816
            1777-3091           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3091
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..107
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            108..277
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            278..439
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            440..591
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            592..700
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    644..646
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            701..1243
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..1834
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 7;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 2"
                     /protein_id="NP_001424461.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTAQASSNTELAL
                     GGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCFNSKLFLCSIC
                     FCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCSSVATPGQVKE
                     LVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTL
                     CRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWL
                     EKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKHFTDPDSPCFN
                     RLFHAVDVNGDIWEDEIED"
     misc_feature    1046..1222
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1046..1222
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1307..1477
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1307..1477
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1574..1777
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1574..1777
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            1244..1472
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1645
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1776
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..3091
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggtgcc cggtgactgc aggcctggct ggctagcgtg ttgcgagggc cccagtcaag
       61 ggcatactgc ggaactttcg ggcccggctc agctaagcgg ccggaagatg gcagaatttc
      121 tgtagtatat tggatgcaaa tcccacatct tggtttctta tccagcttca gtctagcttc
      181 actggctaga aaataaatgg gatttgcaca aattccaagc cacagtgaaa taacgcttgc
      241 agcattgata tccttttctc ctcgttgtta ctaacagaaa attcaatgtc ggcagaagac
      301 ctggaagccc aggaggatga actactggcc ctggcaagta tttatgatgg agatgagttt
      361 agaaaagcag agtctgtcca aggaggggaa accaggatct atttggatct gccacagaat
      421 ttcaagatat tcgtgagcgg caattcaaat gagtgtctcc agaatagtgg ctttgaatac
      481 accatttgct ttctgccacc acttgtgctg aactttgaac tgccaccaga ttatccatcc
      541 tcctccccac cttcattcac acttagtggc aaatggctgt caccaactca gcccatttac
      601 tattcatatg agcctcacaa atttctgttg gatagatttg ttataggaag tgcagttaat
      661 ccaaaagagg aacagaaggg tatgggagaa gagaacacag ctctctgctc tctgcaagca
      721 cctggacaac ctgtgggaag aacaccgagg ccgtgtggtg ctgtttgcct ggatgcagtt
      781 tcttaaggag gagaccctta cctacctgaa tattgtctct ccttttgagc tcaagatggg
      841 gtctcagaaa aaggttcaga gaaggacaac agctcaggcc tcttccaaca cagagcttgc
      901 tttgggagga gctgctgctg ctgctgctgc gtcagatgta gaccaagaag acagtgtgga
      961 tgagagagct gtacaggatg tagaatcatt gtcaagtctg atccaggaaa tcttggactt
     1021 caatcaagat cgacagatga agtgcttcaa tagtaaactg ttcttgtgca gtatctgttt
     1081 ctgtgagaag ctggggagtg attgtatgta cttcttggag tgcagacatg tatattgcaa
     1141 agcctgtctg aaggattact ttgaaatcca gatcaaagat ggtcaagtta aatgcctcaa
     1201 ctgtccagaa ccacagtgtt cttcggtggc tactcctggt caggtcaaag agctggtaga
     1261 agcagactta tttgctcgct atgaccgcct cctcctccag tctactttgg atctaatggc
     1321 agatgtggtg tattgtcccc gtccatgctg ccagctccct gtgatgcaag agcctggtgg
     1381 caccatggct atctgctcca gctgcaattt tgccttctgc accttatgca gactgaccta
     1441 tcacggggtt tctccatgta aggtaacggc agagaaatta atagacttac ggaatgaata
     1501 cctacaagca gatgaagcta ctaaaaggtt cttggaacag aggtatggca agagggtgat
     1561 tcagaaggcc ctggaggaga tggagagtaa agactggctg gagaagaact ccaagagctg
     1621 cccctgctgt ggaacgccca tacagaaatt agacggctgc aacaagatga cctgtactgg
     1681 ctgtatgcag tatttctgct gggtttgcat gggctctctc tcaagagcaa acccttacaa
     1741 acatttcact gatcctgatt ctccatgctt taacaggttg ttccatgccg tggatgtcaa
     1801 tggagacatt tgggaagatg agattgagga ctagttcatt cctgctcgca atgtagaaat
     1861 ggaatggttt gccctgacct tctgtcaagt acacaaagag ccctcgcagg atatttaggg
     1921 taccatctat tcactcttca gtgtagaagg aagaacaggg tttatatttt cctttggttc
     1981 tactgattaa ggcacgtaca tttccatgta acataatctg ataaaattat atgccaaagg
     2041 atcagaaatg aaaactatag attaaatatt ataatatgcc caaactgtga atagttaaaa
     2101 agtaaatatt tattttctcc cccaagcttt aggttaggga gagggtcaag agttaagctt
     2161 ttagaccatg tccaagaagc ccctgcagct ggggacagtc acagccccag ccacactgtc
     2221 ctgggagcct gatccattct ctgtacactg ctcatttcca ttcgtgcttt ggagagagcc
     2281 tctgctctgt aactgaccaa atgtccagtg ttgttctgtt gtactgcttg ccagaataga
     2341 aatctataat aaattaaaaa atatttttag tattataatc cctgtgggtc acttgatatt
     2401 tatgaatagt gtattgaatc ccctggttta gagccaaatg tagaatttag gattctggct
     2461 cagaattcct ctagattcag agtcagagct gtctgtgctc ccttttgttc tcagctttct
     2521 ccctttgcct cccaccttct gttggcaagt acagttttaa tgttgattac agcagtgtgt
     2581 gtctttattt cctctgctag aatagaaaag agcccaatat attcctcatg aatgctctct
     2641 gaacctgtga acagcatcat ggttctaccc caccttctga acactcggga attgggcttc
     2701 ctcccctccc ctcccctcgt agacagcagt gtttggagtg ataatagtag cttgatagct
     2761 agattcctaa ccctggcttt tattggcttt ttgaaaaact gtcttcctcc tgattcccta
     2821 agtggcttgg tgtagtcact tggtggatgt tttggaaagg acagtaactc acctgtagct
     2881 tgtgaacttg tgttttctac tgtgacattg aaaattaagg attgcttaac tgtcagctca
     2941 aactgttgct ggattgtcaa tgaggatgct taatcttaac aataaagtaa tttaaaatca
     3001 tcccgtaatt ggagtaggca tggtgtctgt tgcttctgtc accaaagcac tgactgaatt
     3061 aaaactgact gtgtttctgt ttgttctgtt a
//
LOCUS       NM_001437526            3250 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 24 (Zfp24), transcript
            variant 3, mRNA.
ACCESSION   NM_001437526 XM_006254465
VERSION     NM_001437526.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Howng,S.Y., Avila,R.L., Emery,B., Traka,M., Lin,W., Watkins,T.,
            Cook,S., Bronson,R., Davisson,M., Barres,B.A. and Popko,B.
  TITLE     ZFP191 is required by oligodendrocytes for CNS myelination
  JOURNAL   Genes Dev 24 (3), 301-311 (2010)
   PUBMED   20080941
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Wang,H., Sun,R., Liu,G., Yao,M., Fei,J. and Shen,H.
  TITLE     Characterization of the target DNA sequence for the DNA-binding
            domain of zinc finger protein 191
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 40 (8), 704-710 (2008)
   PUBMED   18685786
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Wu,Y., Yu,L., Bi,G., Luo,K., Zhou,G. and Zhao,S.
  TITLE     Identification and characterization of two novel human SCAN
            domain-containing zinc finger genes ZNF396 and ZNF397
  JOURNAL   Gene 310, 193-201 (2003)
   PUBMED   12801647
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Albanese,V., Biguet,N.F., Kiefer,H., Bayard,E., Mallet,J. and
            Meloni,R.
  TITLE     Quantitative effects on gene silencing by allelic variation at a
            tetranucleotide microsatellite
  JOURNAL   Hum Mol Genet 10 (17), 1785-1792 (2001)
   PUBMED   11532988
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254465.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.76373.1,
                                           SRR26360186.2712890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840121
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000018.1  15581415-15581630   c
            217-716             JAXUCZ010000018.1  15578901-15579400   c
            717-864             JAXUCZ010000018.1  15578524-15578671   c
            865-3250            JAXUCZ010000018.1  15573031-15575416   c
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3250
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zinc finger protein 24"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
     exon            1..216
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            217..716
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="upstream in-frame stop codon"
     CDS             297..1403
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zfp-191; zinc finger protein 191"
                     /codon_start=1
                     /product="zinc finger protein 24"
                     /protein_id="NP_001424455.1"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
                     /translation="MSAQSVEEDSILIIPNPDEEEKILRVKLEEDPDGEEGSSISWNH
                     LPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVA
                     ILPRELQTLVREHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEEIASQED
                     AQGLPSSELDAVENQLKWASWELHSLRHCDDDATAENGALAPKQEIASAGESHEVPGT
                     LNIGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGE
                     KPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKP
                     YECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV"
     misc_feature    438..773
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    438..773
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    690..692
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    720..722
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    <1041..1283
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <1041..1283
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1047..1199
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNK3.1);
                     Region: Necessary and sufficient for nuclear localization.
                     /evidence=ECO:0000250"
     misc_feature    1053..1115
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1053..1115
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1068..1070,1074..1076,1080..1082,1086..1091,
                     1098..1103,1110..1112,1152..1154,1158..1160,1170..1175,
                     1182..1187,1194..1196,1236..1238,1242..1244,1248..1250,
                     1254..1259,1266..1271,1278..1280)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1068..1070,1074..1076,1080..1082,1086..1091,
                     1098..1103,1110..1112,1152..1154,1158..1160,1170..1175,
                     1182..1187,1194..1196,1236..1238,1242..1244,1248..1250,
                     1254..1259,1266..1271,1278..1280)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1116..1118
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1137..1199
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1137..1199
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1170..1172
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1209..>1370
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1209..>1370
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1221..1283
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1221..1283
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1299..1301
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1305..1367
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1305..1367
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            717..864
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            865..3250
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagtcccgc cggtcccggg cggaagtgcc tgtcctgtgt ggcggggtgg ttctggggct
       61 tctgcagccc ttcctggtga atgctgggaa gaggacgtcc gagttgctgg ggcaggctgg
      121 gctcagcgct gtgaggcggg cggtcgctga agaccaggat cccgccgagt gccggacggc
      181 gttcctccac atcccacgag cttggtgcag tacaaagagt acttttgagg aaaacagggt
      241 atttctgagg tctgtacctt gcctcagttg ccttttcttg gaggtattgt aacaggatgt
      301 ctgcccagtc agtggaagaa gattcaatac ttatcatccc aaatccagat gaagaagaaa
      361 aaattctgag agtgaaacta gaggaggatc ctgacggtga agaaggatcg agcatttcct
      421 ggaaccatct ccctgacccg gagattttcc ggcagcggtt caggcagttt ggataccagg
      481 attcaccagg accgcgagag gcggtgagcc agctccgaga actgtgccgc ctgtggctca
      541 gaccggagac gcacacgaag gagcagatac tggagctggt ggttttggag cagtttgtcg
      601 ccatcctccc cagggagcta cagactttgg ttcgagagca tcacccagag aacggagagg
      661 aggcagtgac tgttctagag gacttggaga gtgaacttga tgaccctgga cagccggttt
      721 ctctccgtcg gcggaaacgg gaagtacttg tagaagagat agcatctcaa gaagacgctc
      781 agggattacc gagttctgag cttgacgccg tagagaacca gctcaagtgg gcatcctggg
      841 aactccactc tctgaggcac tgtgatgatg atgctacggc agagaatgga gccctggccc
      901 caaagcagga gatcgcttca gcgggagagt ctcacgaggt tcctggcact ctcaacatag
      961 gtgttcctca gattttcaaa tatggagaaa cctgttttcc caagggcagg tttgaaagaa
     1021 agagaaatcc ttccagaaag aaacaacaca tatgtgacga gtgtgggaaa cacttcagtc
     1081 agggctctgc ccttattctt catcagagaa tccacagcgg ggagaagcct tacggatgtg
     1141 tcgaatgtgg gaaagccttc agcagaagct ccatcctggt gcagcaccag agagtccata
     1201 ctggagaaaa accctacaag tgtctcgaat gtgggaaagc ctttagccag aattctgggc
     1261 tcattaacca tcagcgaatc cacactgggg agaaaccgta tgaatgtgtt cagtgtggga
     1321 aatcctatag tcaaagctca aatcttttta gacatcagag aagacacaat gcagaaaaac
     1381 ttttaaatgt tgtgaaggtt taagaaatta tgaggaaaca atcagcactc aggtcttttt
     1441 cttcagaaat gaagacaaaa ttaaaaagtg aagagatatg gaaactattt ttccccattg
     1501 actgagaaaa tctactggga aataaaaaaa aaaaaatctt cattcaccat tattaccttg
     1561 aaagaaatgg tgttatacct gcctagaaac cgaaatttta aataattcag gtgttaataa
     1621 cctaaatttt ccatgtgatg tttatatttt ctttttttct ccccaagtaa ttagatgcct
     1681 ggttctctgt ccctcccctt tttcagacag ctactttatt tctgtgttga tcactggagg
     1741 ggtgttctgt gagggtgcac acctttttgt tttaaagggc aacacaggaa ttgtaaaatc
     1801 taaagcccat cttcaaggtt tagaaccatc cttgaaagct tagcttcctt ttgttcaggt
     1861 tgagaagata acggccaaag ccgcagtcag ataagcctta agtctcagac gagagatggc
     1921 agcaaaactt ccaggagcgg agggacaact ggggaagttc cctggtgaag catgtctctt
     1981 aagtacagtc agtctacagg aaacctccaa aggaaaaagt gattttacct aacttgtggg
     2041 aatcttacta actaaaatgg ttttcctgtg taaacacaga caattgtaga agtgatggta
     2101 aatcaaacac taaggaagaa tgtagtgata ttgaaaggca aatgtaaaat taaagtaatt
     2161 atatgtatga catggctttt agaaaaattc ttaactcatt ttgcctcatc ctagttaagg
     2221 acagggaatt ccgtgatagg gtgggcagca atatcaggtt tgctattttt attcctttgg
     2281 tacaaaaggg ttgaacacca ggctaaaaca gccatacatt tcttattaaa cgtttctact
     2341 gacagtgcac tgtgctgggt actgtaatcc tacctaagca ggtaggtatt cgctccactg
     2401 taagtcatga ggggtttccc catcaccatt cccagccacc tctgagagcg ccagagctgt
     2461 agttctcttg ccagtgtgtt gtgtttggag ggagagctag ctggtcagct cttagcgttc
     2521 ttcagagctg agctcaagac acactcttag tttgaaagtt tatgaatctt aaaaatccaa
     2581 acatttctag tagcattgtg gttgtagcta cacattgaat ggactgtact ttaaacaact
     2641 aagctattaa ttactagttt attaacggtc agaattgatt ttctaatcta cagtcttaac
     2701 acattttttt aaagaagtat taaaagtaat acattttagt agtaggattc tgtatgcctt
     2761 ggctaagaat ccaagtactg tggttctact gtttaatgga aaactctgga agttaaagca
     2821 gtgggtaaga gaagaggttt tgtttggttt tgttttgttt tgtatgtaag acaggcattg
     2881 ttacatggaa aattatccat gcaagtacaa atattttata gctccagtta tttgggtcct
     2941 atctggtgct tcgtcaaatt ttaacgtgaa aagtgaggtt tttgagtgaa cctggtgaaa
     3001 agcagtaaaa aatgcagcac cgctgctgag gtgaggcaga atgacgcttg ttcatgattt
     3061 tctgagaaca attataagaa atgtgcttta tagatgaaga tttattgagg tataaatatg
     3121 tagtaatgct ataatgtatt tttaagttat acaagaaaat gtagggactt ttgtttgggt
     3181 ctttctctgt ggctgagagg aaacaagtta atgtccaata aagctggaaa ctcctctgct
     3241 ctaagataaa
//
LOCUS       NM_001437522            2877 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus dynamin 3 (Dnm3), transcript variant 5, mRNA.
ACCESSION   NM_001437522 XM_063272015
VERSION     NM_001437522.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Reubold,T.F., Faelber,K., Plattner,N., Posor,Y., Ketel,K.,
            Curth,U., Schlegel,J., Anand,R., Manstein,D.J., Noe,F., Haucke,V.,
            Daumke,O. and Eschenburg,S.
  TITLE     Crystal structure of the dynamin tetramer
  JOURNAL   Nature 525 (7569), 404-408 (2015)
   PUBMED   26302298
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Li,J., Zhang,D.S., Ye,J.C., Li,C.M., Qi,M., Liang,D.D., Xu,X.R.,
            Xu,L., Liu,Y., Zhang,H., Zhang,Y.Y., Deng,F.F., Feng,J., Shi,D.,
            Chen,J.J., Li,L., Chen,G., Sun,Y.F., Peng,L.Y. and Chen,Y.H.
  TITLE     Dynamin-2 mediates heart failure by modulating Ca2+ -dependent
            cardiomyocyte apoptosis
  JOURNAL   Int J Cardiol 168 (3), 2109-2119 (2013)
   PUBMED   23410488
  REMARK    GeneRIF: DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic
            death of cardiomyocyte.
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Grossman,G.H., Ebke,L.A., Beight,C.D., Jang,G.F., Crabb,J.W. and
            Hagstrom,S.A.
  TITLE     Protein partners of dynamin-1 in the retina
  JOURNAL   Vis Neurosci 30 (4), 129-139 (2013)
   PUBMED   23746204
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Tanifuji,S., Funakoshi-Tago,M., Ueda,F., Kasahara,T. and Mochida,S.
  TITLE     Dynamin isoforms decode action potential firing for synaptic
            vesicle recycling
  JOURNAL   J Biol Chem 288 (26), 19050-19059 (2013)
   PUBMED   23687302
  REMARK    GeneRIF: dynamin isoforms select appropriate vesicle reuse pathways
            associated with specific neuronal firing patterns
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Gray,N.W., Fourgeaud,L., Huang,B., Chen,J., Cao,H., Oswald,B.J.,
            Hemar,A. and McNiven,M.A.
  TITLE     Dynamin 3 is a component of the postsynapse, where it interacts
            with mGluR5 and Homer
  JOURNAL   Curr Biol 13 (6), 510-515 (2003)
   PUBMED   12646135
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Zhang,Y., Moheban,D.B., Conway,B.R., Bhattacharyya,A. and
            Segal,R.A.
  TITLE     Cell surface Trk receptors mediate NGF-induced survival while
            internalized receptors regulate NGF-induced differentiation
  JOURNAL   J Neurosci 20 (15), 5671-5678 (2000)
   PUBMED   10908605
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Cao,H., Garcia,F. and McNiven,M.A.
  TITLE     Differential distribution of dynamin isoforms in mammalian cells
  JOURNAL   Mol Biol Cell 9 (9), 2595-2609 (1998)
   PUBMED   9725914
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   Cook,T., Mesa,K. and Urrutia,R.
  TITLE     Three dynamin-encoding genes are differentially expressed in
            developing rat brain
  JOURNAL   J Neurochem 67 (3), 927-931 (1996)
   PUBMED   8752097
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Nakata,T., Takemura,R. and Hirokawa,N.
  TITLE     A novel member of the dynamin family of GTP-binding proteins is
            expressed specifically in the testis
  JOURNAL   J Cell Sci 105 (Pt 1), 1-5 (1993)
   PUBMED   8360266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063272015.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.42632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000013.1  77371058-77371389   c
            333-406             JAXUCZ010000013.1  77297301-77297374   c
            407-556             JAXUCZ010000013.1  77240975-77241124   c
            557-760             JAXUCZ010000013.1  77239796-77239999   c
            761-859             JAXUCZ010000013.1  77215985-77216083   c
            860-1020            JAXUCZ010000013.1  77215253-77215413   c
            1021-1163           JAXUCZ010000013.1  77212750-77212892   c
            1164-1299           JAXUCZ010000013.1  77207732-77207867   c
            1300-1367           JAXUCZ010000013.1  77205597-77205664   c
            1368-1506           JAXUCZ010000013.1  77202373-77202511   c
            1507-1593           JAXUCZ010000013.1  77190691-77190777   c
            1594-1664           JAXUCZ010000013.1  77181775-77181845   c
            1665-1716           JAXUCZ010000013.1  77169168-77169219   c
            1717-1830           JAXUCZ010000013.1  77130509-77130622   c
            1831-1940           JAXUCZ010000013.1  77034331-77034440   c
            1941-2052           JAXUCZ010000013.1  76990952-76991063   c
            2053-2217           JAXUCZ010000013.1  76926535-76926699   c
            2218-2444           JAXUCZ010000013.1  76918517-76918743   c
            2445-2681           JAXUCZ010000013.1  76917749-76917985   c
            2682-2877           JAXUCZ010000013.1  76892327-76892522   c
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2877
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="dynamin 3"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
     exon            1..332
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2718
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /EC_number="3.6.5.5"
                     /note="isoform 5 is encoded by transcript variant 5;
                     T-dynamin; dynamin, testicular; testicular dynamin"
                     /codon_start=1
                     /product="dynamin-3 isoform 5"
                     /protein_id="NP_001424451.1"
                     /db_xref="GeneID:171574"
                     /db_xref="RGD:727949"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIE
                     AETDRVTGMNKGISSVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KSTIGNQVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNL
                     KVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKASLLRAGVYPD
                     KSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINN
                     VKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALAIIGDINTVTV
                     STPAPPPVDDSWLQHSRRSPPPSPTTQRRLTLSAPLPRPASSRGPAPAIPSPGPHSGA
                     PPVPFRPGPLPPFPNSSDSYGAPPQVPSRPTRAPPSVPRRPPPAVPGRPS"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    187..906
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin, GTPase; Region: DYNc; smart00053"
                     /db_xref="CDD:197491"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    283..306
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(286..288,292..309,346..351,364..366,577..579,
                     787..789,793..798,874..888,895..897)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(289..294,589..591,628..630,703..705,709..711,
                     715..726,730..735,796..798,802..813,883..891)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    361..369
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    364..366
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    376..384
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    577..588
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(583..588,676..681)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    784..795
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    814..1677
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    862..864
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    874..885
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08877.2);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    874..882
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1066..1068
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P39054; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    1711..2046
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    1711..2046
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin pleckstrin homology (PH) domain; Region:
                     PH_dynamin; cd01256"
                     /db_xref="CDD:269958"
     misc_feature    order(1717..1719,1723..1728,1732..1734,1783..1785,
                     1990..1995,2002..2004,2011..2016,2023..2025)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    order(1717..1719,1723..1728,1732..1734,1783..1785,
                     1990..1995,2002..2004,2011..2016,2023..2025)
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:269958"
     misc_feature    1948..1950
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39052; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    1951..1953
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50570; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); acetylation site"
     misc_feature    2104..2376
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2104..2376
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    <2398..2658
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    <2398..2658
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; Region: MISS; pfam15822"
                     /db_xref="CDD:318115"
     misc_feature    2446..2448
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    2458..2460
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     misc_feature    2698..2700
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:17376771; propagated from
                     UniProtKB/Swiss-Prot (Q08877.2); phosphorylation site"
     exon            333..406
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..556
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..760
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..859
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1020
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1163
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1299
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1367
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1506
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1593
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1664
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1716
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1830
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1940
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2052
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2217
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2444
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2681
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2877
                     /gene="Dnm3"
                     /gene_synonym="dynamin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagctgtc aggagcctag cagcgggtgg cagggatcgg acgacggtgc cgggactcag
       61 cggtgtgagc cccgcgcatc aacaaaccgg acaagtgctg cgaggcccgg gctgcctgcc
      121 aggtcgctga gtcgcgcagg gacctgtggg gcagttggcc gcacaggcaa gatggggaac
      181 cgggagatgg aagaactgat ccctctggtg aaccgtctgc aggacgcttt ctcggctctg
      241 ggacagagct gtctgctgga gctgccacag atcgccgtgg tgggcggcca gagcgccggc
      301 aagagctcag tgctcgagaa cttcgtgggc agggactttc ttcctcgagg ctcgggcatt
      361 gtgaccagac gacctcttgt actccagctt gtcacctcta aagcagaata tgccgagttt
      421 ctacattgca aaggaaaaaa atttacagat tttgatgaag ttcgccacga gatcgaagca
      481 gaaacggacc gagtaacagg aatgaataaa ggcatctcct ctgtacccat taaccttcga
      541 gtctactctc cccacgtgtt aaacctaacg ctaatcgacc tacctggaat aacgaaagtg
      601 cccgtgggag accagccgcc agatattgag tatcagatca gagatatgat tatgcagttc
      661 atcaccaggg agaactgtct gattttggct gtcacaccag ccaacaccga tcttgcgaac
      721 tcagatgccc tgaagctagc caaagaagtc gatcctcaag gcctgaggac cattggcgtt
      781 atcaccaagc tggatctcat ggatgaaggg acggatgcca gggatgtact agagaacaag
      841 ctgctacctc tccgcagggg ctatgtgggg gtggtcaacc gaagccagaa ggacatagat
      901 ggaaagaagg acattaaggc agctatgctg gcagaaagga aattttttct ctctcatcca
      961 gcatatagac acattgctga tcggatgggg accccacacc tccagaaggt cctgaatcag
     1021 caacttacca accatatccg agataccctg cccaacttca ggaacaagct acaggggcag
     1081 ctgctctcca tagaacatga agtagaagcc ttcaaaaact tcaaaccgga agaccccaca
     1141 aggaagacca aagcactgct acagatggtc caacagttcg ctgtggactt tgagaagaga
     1201 atcgaagggt cgggggatca agtagacacg ttagagctct ctggcggtgc taagatcaat
     1261 cgcattttcc acgaacgctt tccttttgag atagtgaaga tggagttcaa tgagaaagaa
     1321 ctgagaagag aaataagcta tgcaatcaaa aacatacacg ggatcaggac agggttgttt
     1381 actccagaca tggcgtttga ggcaatagtc aaaaaacaga tagtaaaact gaaagggcct
     1441 tctttgaaga gtgtggacct ggtgatgcag gaactgatca acacggtgaa gaagtgcacc
     1501 aagaggctgg ccaacttccc cagactttgt gaagaaacag aaaggattgt tgctaaccac
     1561 atccgtgagc gagaaggaaa gaccaaggac caggtcctgc tactgattga cattcaagtc
     1621 tcttacatta acaccaacca tgaggacttc atcggctttg caaatgctca gcagagaagc
     1681 agtcaggttc acaagaaaag cacaattgga aatcaggtga ttcggaaggg ctggctgacc
     1741 gtcagcaaca ttggcatcat gaaaggaggc tcgaagggct actggtttgt cctcacggca
     1801 gaaagcttgt cctggtataa agacgatgag gagaaagaaa agaagtatat gcttccactg
     1861 gacaacctga aagtccggga cgtggagaaa ggcttcatgt ccagcaagca cgtcttcgca
     1921 ctcttcaaca cagaacaaag gaatgtctac aaagactatc gttccctgga gctggcctgt
     1981 gattcccagg aggatgtgga cagctggaag gcgtctctgc tcagagctgg cgtctatcca
     2041 gacaagtctt ttactgaaaa tgatgaaaat ggacaagcag aaaacttctc catggacccg
     2101 cagttggaga ggcaagtgga gactattcgc aacctcgtag actcctacat gtcgataatc
     2161 aacaaatgca tccgagacct aattccaaaa acaataatgc accttatgat caataatgtt
     2221 aaagacttca tcaactctga actcctagca cagctctact cctctgagga ccagaacaca
     2281 ctaatggaag aatccgtgga gcaggctcag cgccgggatg agatgctccg gatgtaccaa
     2341 gccctgaaag aagccctcgc gatcattggc gacatcaaca cggtcactgt gtccacccca
     2401 gccccacctc cagtagatga ctcctggctc cagcattcca gaaggtcacc tcctccaagc
     2461 cccaccaccc aaagaaggct gactctaagt gctcccctcc cgaggcccgc atctagccgt
     2521 ggaccagctc ctgccattcc ctctccaggc ccccactctg gggctccccc agtcccattc
     2581 cgtccaggcc cattacctcc ttttcccaac agcagtgact cctacggagc ccctccacag
     2641 gttccatcca ggcccacaag ggcacccccc agtgttccaa ggagaccccc tcctgcagtt
     2701 ccaggccgac catcctaacc ccatcaccta gtcatctcct tttgtttaac agcatatcta
     2761 cccatgctat taaaaaaaaa aaaaaaaaaa acttctgttt gcaccatatg tcacgtgtac
     2821 ataaaaactt ttatttttga tctatgtctt taattaaaaa aataaagtat tctatat
//
LOCUS       NM_001437447            1869 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 5, mRNA.
ACCESSION   NM_001437447 XM_006229018
VERSION     NM_001437447.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229018.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2994.1,
                                           SRR26360181.1016221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-729             JAXUCZ010000001.1  104572222-104572332
            730-1016            JAXUCZ010000001.1  104572931-104573217
            1017-1211           JAXUCZ010000001.1  104574234-104574428
            1212-1385           JAXUCZ010000001.1  104574810-104574983
            1386-1521           JAXUCZ010000001.1  104576616-104576751
            1522-1689           JAXUCZ010000001.1  104577665-104577832
            1690-1869           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1869
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1767
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 5 is encoded by transcript variant 5; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     5"
                     /protein_id="NP_001424376.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTN
                     VLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCS
                     GPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARW
                     HQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVER
                     SAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQ
                     QLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILPSPVSPAAPTLLSPGA
                     GAPGLGQTRQGRGPELHPSAGPRRSRSGQEPTADGQDEAGGEGGHFGLYAFEDVFPPR
                     PTQPPAT"
     misc_feature    187..>1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..>1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>819
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    715..717
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    829..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    886..888
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    970..972
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..729
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1016
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1211
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1385
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1521
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1689
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1869
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaaggg cccccgccct gatgttctga cccaggagaa ctgccgcaag
      661 gtgacccgtt cagtggaaga cgctgaaatc aaaaccaatg tcctgaagca gaactctgcc
      721 ttgttggagg agaagctaag atacctccag cagcaactgc aggatgagac gccccggaga
      781 caggaggccg agttgcagga gctggagcaa aaactagagg ctggcctctc ccggcatggc
      841 ctaggcccta ctactcccat tcagggctgc tccggtcctc ctggtagccc ggaggaaccc
      901 ccgcggccgc gaggcctgcc ctccaatggc tggggcatgg caatccgcgc aggggaggga
      961 ccctcgctga gcgagcagga gttgcagaag gtctccagcg gcctagagga gctgaggagg
     1021 gaggtgtcct cgctggcagc tcggtggcat caggaggagg gggcggtgca ggaggcccta
     1081 aggttgctgg gaggcctggg cggccgtctg gatggctttc tgggccaatg ggagcgggcg
     1141 cagcgggaac aagcacagtc cgcacggggt ttgcaggagc tgcgaggacg agcagatgag
     1201 ctgtgcacta tggtggagag gtcagcagtg tctgtcgctt cactgaggag cgaactggag
     1261 gcactgggcc cagtaaaacc gattctggag gagctgggac ggcaacttca aaactcccga
     1321 aggggacctg accatgtctt gaacttggat cgtcctgccc aaggtccctg tcctcgatgt
     1381 gccagccagg ggcagcagtt atccacggag tccctacagc agctgctgga acgtgcgctg
     1441 accccactgg tggacgaagt gaagcagaag ggtctggctc ctgcctgccc cagttgccag
     1501 aggctacaca agaagattct gcccagtcca gtaagcccag cggcgcctac actcctctcc
     1561 ccaggagctg gagcgccagg ccttggccaa acacgtcagg gcagaggccc tgagctccac
     1621 ccttcggctg gcccaagacg aagccgttcg ggccaagaac ctactgctga cggacaagat
     1681 gaagccggag gagaaggtgg ccactttgga ctatatgcat ttgaagatgt gttccctcca
     1741 cgaccaactc agccacctgc cacttgaggg gtccacaggg gcaatggggg gaggaagcac
     1801 tggaggggct ccccctaaac gtgggggtcc aggctctgaa caataaatgg cctctcatgc
     1861 tggcatgaa
//
LOCUS       NM_001437505            5514 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 532 (Zfp532), transcript
            variant 2, mRNA.
ACCESSION   NM_001437505
VERSION     NM_001437505.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.497092.1,
                                           SRR21887622.497091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000018.1  61364771-61365118
            349-458             JAXUCZ010000018.1  61366855-61366964
            459-2812            JAXUCZ010000018.1  61414137-61416490
            2813-2925           JAXUCZ010000018.1  61467135-61467247
            2926-3076           JAXUCZ010000018.1  61469855-61470005
            3077-5514           JAXUCZ010000018.1  61471223-61473660
FEATURES             Location/Qualifiers
     source          1..5514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5514
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc finger protein 532"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
     exon            1..348
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            349..458
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    371..373
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="upstream in-frame stop codon"
     exon            459..2812
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..3571
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 532 isoform 2"
                     /protein_id="NP_001424434.1"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
                     /translation="MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHIKQN
                     AHVDDDSHTPSSSDVGVSVIVKNVRNIDSSEGVEKDGHNPTGNGLHNGFLTASSLDSY
                     GKDGAKSLKGDTPASEVTLKDPAFSQFSPISSAEEFEDDEKIEVDDPPDKEETRANFR
                     SNVLTGSAPQQDFDKLKALGGENTSKTGVSASGHADKNKVKREAESNSITLSVYEPFK
                     VRKAEDKLKENSEKMLESRVLDGKPSSEKNDPAIAAATSSKTKSSSKLSSCIAAIAAL
                     SAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKSPESQNLIDGTKKASLKPSDSP
                     RSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPS
                     EQAASVMASVTSLLSSSASAAVLSSPPRAPLPTAMVTSAVSSAELTPKQVTIKPVATA
                     FLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPA
                     SSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAILNAAAAQPPKKV
                     SRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPASAGITLPMRGYKCLECGDSF
                     ALEKSLSQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILK
                     PVPADQMIVSPSSNTAASTLPSSVGAATHTVAKVQPGLTGAVISAPPSTPISPAMPLD
                     EDPSKLCRHSLKCLECNEVFQDETSLATHFQHAADTCGQQMKKHPCRQCDKSFSSSHS
                     LCRHNRIKHKGIRKVYACSHCPDSRRTFTKRLMLEKHIQLMHGIKDPDVKELSDEVTN
                     EEEVEIKEDAKVPSPKRKLEEPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTE
                     NLLQFHEHIPQHKSDGSSYQCRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGE
                     DSQQENKPSPEDEAAEGAVSDRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAE
                     K"
     misc_feature    2732..2791
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2732..2791
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2747..2749,2753..2755,2759..2761,2765..2770,
                     2777..2782,2846..2848,2852..2854,2864..2869,2876..2881,
                     2888..2890,2945..2947,2951..2953,2957..2959,2963..2968,
                     2975..2980)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2747..2749,2753..2755,2759..2761,2765..2770,
                     2777..2782,2846..2848,2852..2854,2864..2869,2876..2881,
                     2888..2890,2945..2947,2951..2953,2957..2959,2963..2968,
                     2975..2980)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2831..2896
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2831..2896
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2921..2983
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2921..2983
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3191..3253
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3191..3253
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3206..3208,3212..3214,3218..3220,3224..3229,
                     3236..3241,3248..3250,3293..3295,3299..3301,3311..3316,
                     3323..3328,3338..3340,3476..3478,3482..3484,3488..3490,
                     3494..3499,3506..3511,3518..3520)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3206..3208,3212..3214,3218..3220,3224..3229,
                     3236..3241,3248..3250,3293..3295,3299..3301,3311..3316,
                     3323..3328,3338..3340,3476..3478,3482..3484,3488..3490,
                     3494..3499,3506..3511,3518..3520)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3266..3346
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    3266..3346
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    3278..3343
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3278..3343
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3458..3523
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    3458..3523
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    3461..3523
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3461..3523
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            2813..2925
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3076
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..5514
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgttcg ctcgccgccc gggcggcccg agcgctaggc cccggcgtgg cccgggccga
       61 gccgccgccg cgcggcctag agcccgcgcc ccggagcggg gccggcgtcc gggcgcaccg
      121 cgaggccgcg gcagcgagga gccctagggc ggcgaggccg ggctccgctc tcgcacacag
      181 accccggcgg cggggaggcg cgacacgccc gtagcatgga agcggccgcc gctcgcactg
      241 cagcgggcgc agcagcagca gccgccggcg gcgcgcggag cagaggtcgc ccgagccacg
      301 gcccggacac ccgggcttga gcgctacgga ggcccgcccg gccagggggc ctgttgactg
      361 gggctgcttt taaccctttc ctatttgcag agaatgcaac cgtgtgacag taactgagca
      421 ctggtccaaa gtcttttcaa aaggtcaagg ttcacaagaa catctgatca aattcatgac
      481 catgggggat atgaagaccc cagactttga tgacctcttg gcagcgtttg acataccaga
      541 tatggttgat cctaaagcag ccattgagtc tgggcacgat gaccacgaaa gccacattaa
      601 gcagaatgct cacgtggatg acgactctca cacaccatca tcctcagatg ttggcgttag
      661 tgtgattgtg aagaatgttc gcaacatcga ctcctctgag ggagtggaaa aagatggcca
      721 caatcccaca ggcaatggct tgcataacgg gtttctcacg gcctcctctc ttgacagcta
      781 tggtaaggat ggagccaagt ccttaaaagg agacacacct gcctcagagg tgactcttaa
      841 agacccagcg ttcagccagt tcagccccat ctccagcgcc gaggagtttg aggatgatga
      901 gaaaatagag gtggatgacc cacctgataa ggaggagacg agggccaatt tcagatcaaa
      961 tgtgctgacg ggctccgctc cccagcagga cttcgacaaa ctgaaggcac ttggagggga
     1021 aaacacaagc aagactggag tctctgcatc aggtcatgca gataaaaaca aagtcaagag
     1081 agaagcagaa agcaattcca taaccctgag tgtctatgag ccgtttaagg tcagaaaagc
     1141 agaggataag ttgaaggaga actctgagaa gatgcttgaa agcagggtcc tggatgggaa
     1201 gccgagctcc gagaagaacg accctgccat tgctgctgcc acatcttcca aaacaaagtc
     1261 gtcctccaag ctctcgtcgt gcatagccgc cattgcggct ctgagtgcga aaaaggctgc
     1321 atctgactcc tgcaaagagc ctgtggccaa ttccagggaa gcatctccac taccaaaaga
     1381 agtgaatgac agtcccaaag ccgctgacaa gtctccggaa tcccagaatc tcatcgatgg
     1441 caccaagaag gcctctctga agccgtcaga tagtcccagg agcgtatcca gtgagaacag
     1501 cagcaaaggg tccccatcct ctcctgtggg gtctacccca gctatcccca aagtccgcat
     1561 caagaccatc aagacatcat ctggggagat caagaggaca gtgaccagag tactgccaga
     1621 agtggatctg gactctggga agaagccttc tgagcaggca gcgtccgtga tggcgtctgt
     1681 gacgtcactt ctgtcatctt cagcatcagc tgcggtcctc tcctcacccc ccagggcacc
     1741 tctgccgaca gccatggtta ccagtgcggt ttcctctgca gagctgactc ccaaacaggt
     1801 aaccatcaag cccgtggcta cagcttttct tcctgtgtct gccgtcaaga cagcagggtc
     1861 tcaagtcatc aacctgaagc tggctaacaa cacaacggtg aaagccacgg tcatctcggc
     1921 tgcctctgtt cagagcgcca gcagtgccat catcaaagct gccaatgcca tccagcagca
     1981 aaccgttgtg gtgccggcct ccagtctggc caatgccaaa ctcgtgccaa agactgtgca
     2041 ccttgccaac cttaacctcc tgcctcaggg tgcccaggcc acctctgaac tccgccaagt
     2101 gctcaccaaa cctcagcagc aaataaagca ggcaatactc aatgccgcgg ccgcgcagcc
     2161 acccaagaag gtgtcccggg tccaggtggt gtcctccttg cagagttctg tggtggaagc
     2221 tttcaacaag gtgctgagca gcgtcaaccc agtccctgtt tacatcccga acctcagtcc
     2281 tcccgccagt gccgggatca cgttaccgat gcgcgggtac aagtgcttgg agtgcgggga
     2341 ctccttcgcc ctggaaaaga gcctgagcca gcactacgac aggcgcagcg tgcgcatcga
     2401 agtgacgtgc aaccactgta cgaagaacct tgttttttac aacaagtgca gcctcctttc
     2461 ccacgcccga gggcataagg agaaaggcgt ggtgatgcag tgctcccact taatcctaaa
     2521 accagtccca gcagaccaga tgatagtgtc tccgtccagc aatactgctg cttccactct
     2581 gccgagctcg gtgggagctg ccacacacac tgtcgccaaa gtacagcctg gcctaaccgg
     2641 ggcggttatc tcagctcctc caagcacacc catcagccca gccatgcccc tagacgaaga
     2701 cccctccaag ctctgtagac acagtctcaa gtgtttggag tgcaatgaag tcttccagga
     2761 tgagacgtcc ctggccacac atttccagca tgccgcagac acatgtggac aacaaatgaa
     2821 gaagcacccc tgccgccagt gtgacaagtc tttcagctcc tcccacagcc tgtgccgcca
     2881 caatcgcatc aagcacaaag gcatcaggaa ggtttacgcc tgctcgcact gcccagactc
     2941 ccgtcggacc ttcaccaagc ggctgatgct ggagaagcac atacagctga tgcacgggat
     3001 caaagaccct gacgtaaagg agctgagtga cgaggttacc aacgaggagg aagtggagat
     3061 aaaggaggac gccaaggttc ccagtcctaa gcggaagttg gaggagccag ttttagagtt
     3121 caggcctccc cgaggagcca tcactcagcc actgaagaaa ctgaaaatca atgtctttaa
     3181 ggtccacaag tgcgccgtgt gtggcttcac cactgagaac ctgctgcagt tccacgaaca
     3241 catcccccag cacaagtcgg acggctcctc ctaccagtgc cgggagtgcg gcctgtgcta
     3301 cacgtcccac gtctccctgt ccaggcacct cttcatcgtg cacaagctga aggagcctca
     3361 gcctgtgtcc aagcagaacg gggctgggga agacagccag caggagaaca agcccagccc
     3421 ggaggatgag gccgccgagg gggcagtgtc agacaggaag tgcaaagtgt gcgccaaaac
     3481 tttcgaaacg gaagctgcct taaacacaca catgaggaca cacggcatgg ccttcatcaa
     3541 gtccaaaaga atgagttcag ctgaaaaata gccacagaac ttccataaga acaatccctg
     3601 tccacatagg aattgaacgt ttttgttacc aaaagtttgc agtataacag agttaccagt
     3661 tctgtctagg ctgtggcaat agactctttg tcctgccctc tcacctcaga tgtatccctt
     3721 cccataagtg ttaaggcagt atttgagttt taaagagttt gtatatattt aaataacatt
     3781 ttatactctt tgttacatgt ttgtatcagt atttggtgga aaatgttttg agggtttttt
     3841 ttgtgtgtgt atgttaggat tctctttttt tgtactgttt ctttaaaaca gagttcttag
     3901 gggaagttcc tgaattcaaa ccaaccattt tgtatgttga gaatttgaat gagttcagta
     3961 attacaggct atcatgcctt ttttagtgtt tttaattttt agaactcgcc acataaatta
     4021 taggtgattg tgggtcacac aacactagca acttttaagt gtcttagcac cacactcagc
     4081 gtgcctgctc ctagcaaccg agggctccaa ggacagcatc acccagttaa gggcgtggcc
     4141 tgagccatcc cagacagtgt gggaagcagc cttacaggtc cctcctttgc catagtaggt
     4201 aaaagaggcc aggaatccag tagggagtgc ggtcgtcctt aatcccaact ggaagaatga
     4261 ggaagaaggg atccataaag gggagacagt ggagctgggt gaattcgcaa ggtgacttac
     4321 agggcacaag gagacaggct agggaaaggc cagcctgtgg tcaaagttga aagtcatagt
     4381 tagacctgtc gctctctctg tcaggttttg tcatggaact caccaacctt tctagagaca
     4441 cacactacaa gagtaccaag tatttctctg gctcttgata ggaacagaaa ggcacggttg
     4501 acttaaccct ttgctgtcta cacagttggt atttcctgtt ccgggtgcta ctgccaaatg
     4561 ttcgggtact tagtgtcggg atgcacagcc tcaccaccga cctagcactg cagcagcctg
     4621 tactctgcaa ctggcctgag gagccaccag gcttctagag tcgtttcagc accctctcaa
     4681 ggccgcctga ctggagcacc gctgaggtgc tcttcgtcac atccctgcct agttctctga
     4741 gaaaactata tattttggtt attgttttgt gtttttcgtt gcattttgta tcttgtattt
     4801 atctcccgat atgttttgta cttttgtttt cctaaacgag gaaattcatt tgtgtacata
     4861 aatacttgca tgctaaactg tagtccacgt tcagttccct gaaaggtctt gctgctgttg
     4921 gtgcgcaccc tacaccatcg tgactgtatt cagcccattt cacatgtaaa taaaacgagg
     4981 aacatctggc ccttgagctt cttcaagaga gtcattggtg ggtctctgac atcatacagt
     5041 tcggggagtg actcttttgg ggacaggctg cagaatactg cagaattctt tccactctga
     5101 agaatggctt ctcgttctca tcggcgacca gctcactacc ctgccgcttt ctgtcgactg
     5161 tgtcgacaca atccaagggt gcgagatgtt cctcagcttg aaatgtaatt gctgttacgt
     5221 gttacatccg caccgctccc gcccccactc gtggtcatgg cactttcaca cgttcctgca
     5281 tttgaacctt gcaataagcc tgcgtggcgg ccacgcgggt ctgtacagct tacagctgag
     5341 gaagctgcgc tcaggttcag ctcttcgccc gacccctcat agctggtaag tggctttgca
     5401 tattagaacc caaatatttc gctctcagtc tagtattctc gctctttgtg gctatgtaca
     5461 tattgacaga tactcattta ttcaacaaat aaagttatgt gcaaaaacac cata
//
LOCUS       NM_001437496            6539 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 5, mRNA.
ACCESSION   NM_001437496
VERSION     NM_001437496.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6539)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6539)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6539)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6539)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6539)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6539)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6539)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6539)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6539)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6539)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.315137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000001.1  128341704-128341812 c
            110-166             JAXUCZ010000001.1  128325302-128325358 c
            167-291             JAXUCZ010000001.1  128309353-128309477 c
            292-394             JAXUCZ010000001.1  128308404-128308506 c
            395-671             JAXUCZ010000001.1  128306471-128306747 c
            672-775             JAXUCZ010000001.1  128303218-128303321 c
            776-944             JAXUCZ010000001.1  128302666-128302834 c
            945-1092            JAXUCZ010000001.1  128302203-128302350 c
            1093-1232           JAXUCZ010000001.1  128295152-128295291 c
            1233-1338           JAXUCZ010000001.1  128294447-128294552 c
            1339-1489           JAXUCZ010000001.1  128291713-128291863 c
            1490-1598           JAXUCZ010000001.1  128289070-128289178 c
            1599-1818           JAXUCZ010000001.1  128287751-128287970 c
            1819-2003           JAXUCZ010000001.1  128287297-128287481 c
            2004-2099           JAXUCZ010000001.1  128287089-128287184 c
            2100-2182           JAXUCZ010000001.1  128284354-128284436 c
            2183-2393           JAXUCZ010000001.1  128283655-128283865 c
            2394-2494           JAXUCZ010000001.1  128283262-128283362 c
            2495-2845           JAXUCZ010000001.1  128280040-128280390 c
            2846-3715           JAXUCZ010000001.1  128277918-128278787 c
            3716-3813           JAXUCZ010000001.1  128277712-128277809 c
            3814-4041           JAXUCZ010000001.1  128276273-128276500 c
            4042-4208           JAXUCZ010000001.1  128271583-128271749 c
            4209-4683           JAXUCZ010000001.1  128266965-128267439 c
            4684-4901           JAXUCZ010000001.1  128265159-128265376 c
            4902-5045           JAXUCZ010000001.1  128263777-128263920 c
            5046-6539           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..6539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6539
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..109
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..166
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..5140
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 5 is encoded by transcript variant 5; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 5"
                     /protein_id="NP_001424425.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
                     SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQI
                     PVSHPDPDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSD
                     RRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVL
                     KINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDD
                     ISEIQSLASDHSVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERM
                     SKPGAVSTPVKHVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPS
                     DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
                     EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFY
                     IRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKN
                     RAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERV
                     VLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTI
                     KQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSAR
                     KLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATS
                     DDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGT
                     PPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQVYRKE
                     PYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRDLEQPPYRYESS
                     SYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPRDLDSRQHPEEA
                     SERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNRYRPEAQPYAPA
                     GPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQHKPEVLPS
                     ATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVA
                     SKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSNHYDPEEDEEYY
                     RKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAMDRSF
                     SEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSVSLDFQNSYISK
                     PDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTITPAYNRFTPKP
                     YTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDSG
                     VETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVL
                     SSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
                     KFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSV
                     LIDHF"
     misc_feature    146..406
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    146..406
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(179..199,251..253,260..262,344..346,356..358,
                     365..370)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(179..199,251..253,260..262,344..346,356..358,
                     365..370)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    638..871
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    638..871
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(638..655,668..718,725..733,740..742,746..751,
                     770..772,794..799,803..808,842..862)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(638..655,668..718,725..733,740..742,746..751,
                     770..772,794..799,803..808,842..862)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(671..691,707..709,716..718,806..808,818..820,
                     827..832)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(671..691,707..709,716..718,806..808,818..820,
                     827..832)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1346..1585
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1346..1585
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1376..1396,1424..1426,1433..1435,1520..1522,
                     1532..1534,1541..1546)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1376..1396,1424..1426,1433..1435,1520..1522,
                     1532..1534,1541..1546)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1631..1825
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1631..1825
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1631..1639,1721..1729,1742..1744,1751..1753,
                     1808..1810)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1631..1639,1721..1729,1742..1744,1751..1753,
                     1808..1810)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1637..1657,1694..1699,1706..1708,1751..1753,
                     1775..1780,1802..1810,1820..1825)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1637..1657,1694..1699,1706..1708,1751..1753,
                     1775..1780,1802..1810,1820..1825)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1655..1657,1661..1663,1670..1672,1682..1684,
                     1745..1750,1805..1807,1811..1816)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1655..1657,1661..1663,1670..1672,1682..1684,
                     1745..1750,1805..1807,1811..1816)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    1925..2464
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    1925..2464
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    <3356..4585
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3356..4585
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4739..5035
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     misc_feature    4739..5035
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="ZU5 domain; Region: ZU5; pfam00791"
                     /db_xref="CDD:459941"
     exon            167..291
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..394
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..671
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..775
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..944
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1092
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1232
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1338
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1489
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1598
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1818
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2003
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2099
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2182
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2393
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2494
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2845
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3715
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3813
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..4041
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4208
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4209..4683
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4901
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..5045
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5046..6539
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggggtg cgcctgccgc ccgggcaggt gcacggctgc cggtgcctgg ctccggctcg
       61 cgctgggagg cgacatgcaa caggtcccgc gcctgaaaag tcgccccgga gcacagcaat
      121 ggaggaaaca gctatatggg aacagcacac agtgacgctt cacagggctc ctgggtttgg
      181 atttggaatt gcaatatctg gtggaagaga taatcctcat tttcagagtg gggaaacctc
      241 catagtgatt tctgatgtgc taaaaggagg gccagctgaa ggacagctac aggaaaatga
      301 ccgagtcgca atggttaacg gagtttcaat ggataatgtt gaacatgctt ttgctgttca
      361 gcagctaagg aaaagtggga aaaacgcaaa aattaccatc cgaagaaaga agaaagttca
      421 gattcctgta agtcacccag accctgaccc agtgtctgat aatgaagatg atagctatga
      481 cgaggatgtg cacgatccaa gaagtggccg aggtgcccta gctaacagaa ggggtgagaa
      541 gagctgggca agggatagaa gcgcaagcag ggaccggagc ctgtcccctc gctcagacag
      601 gcgatcagtg gcctccagtc agcccgccaa acccaccaag gtcacattgg tgaagtctcg
      661 gaaaaatgaa gaatatggtc ttcgattggc cagccatata tttgtaaagg aaatttcaca
      721 agatagtttg gcagcaagag atggtaacat tcaagaaggg gatgttgtcc tgaagataaa
      781 tggtactgtg acagaaaata tgtcactgac agatgcaaaa acattgatag aaaggtctaa
      841 aggcaagtta aaaatggtag tgcaaagaga tgagcgggct accttattga atgtccctga
      901 tctttcagat agtatccatt ctgctaatgc ctctgaaaga gatgacattt cagaaattca
      961 gtcactagca tcagaccatt cagttcgctc ccatgacagg cctccccgcc gaagccagtc
     1021 acgatctccc gaccaacgtt cagagccctc tgatcattcc acacagtctc cacagcagcc
     1081 cagcaatggc agtctccgga gcagagagga agagcgcatg tctaaacccg gggctgtctc
     1141 aactcctgta aaacatgtag atgatcatac acccaaagca gtggaagaag ttacagttga
     1201 aaaacatgag aagcagacac ccactcttcc agaaccaaaa cctgtatatg ctcaagtcgg
     1261 acagccagat gtggatttac ctgtcagccc ttctgatggt gttctgccaa attcaacaca
     1321 tgaagatggg attcttaggc ccagcatgaa actggtaaaa ttcagaaaag gagatagtgt
     1381 gggtttgcga ctagctggtg gaaatgatgt cggaatattt gtagctggcg ttctagaaga
     1441 tagccctgca gccaaagaag gcttagagga aggtgatcaa attctcaggg tgaacaatgt
     1501 agatttcaca aatatcataa gagaagaagc tgttcttttc ctcctcgacc tccctaaagg
     1561 tgaagaagtg accatattgg ctcagaagaa aaaggacgtt tatcgccgca ttgtagagtc
     1621 agatgtagga gactcgttct atattagaac acattttgaa tatgagaaag aatctcctta
     1681 tggactcagt tttaacaaag gagaggtgtt ccgggtcgtg gacaccctgt acaacgggaa
     1741 gctgggctcc tggctggcca ttcgaattgg caaaaatcac aaggaggtag agcgaggcat
     1801 cgttcctaat aagaacagag ccgagcagtt agccagtgta cagtacacac ttccaaagac
     1861 agcaggtggc gatcgggcag acttctggag gtttcgaggt cttcgtagct ccaagagaaa
     1921 tcttcgaaaa agcagagagg acctgtcagc gcagccagtt caaacaaagt tcccagctta
     1981 tgaaagggtt gttcttcgag aagctggatt cctaagacct gtaaccatct ttggaccgat
     2041 tgctgatgtt gccagagaaa agttagcaag ggaggagcca gacatttatc agattgcaaa
     2101 aagtgaacca cgagatgctg gaactgacca tcggagctcg ggcattattc gccttcatac
     2161 aataaagcaa atcatagatc aagataaaca tgctttatta gatgtcacac caaatgcagt
     2221 cgatcgcctt aattatgcac agtggtatcc gattgttgtg ttccttaacc ctgactctaa
     2281 gcagggtgta aaaacaatga ggatgaggct atgtccagag tctcggaaaa gtgccaggaa
     2341 gctatatgaa cggtctcata aacttcgtaa aaataatcac catcttttta caaccacaat
     2401 taacttaaac tcaatgaatg atggttggta tggtgccctg aaagaagcga ttcagcagca
     2461 acagaaccag ctggtgtggg tctctgaggg gaaggcggat ggtgctacaa gtgatgacct
     2521 tgatttgcat gatgatcgtc tgtcctacct gtcagcccca ggtagtgagt actcaatgta
     2581 tagcacggac agtagacaca cttctgacta tgaagacaca gatacagaag gcggggccta
     2641 cactgatcaa gaactagatg aaactcttaa tgatgaggtg gggactccac cggagtctgc
     2701 tattacacgg tcctctgagc ctgtaagaga ggattcctct ggaatgcatc atgaaaacca
     2761 aacatatcct ccttactcac cacaagcgca gccacaagct attcatagaa tagactcccc
     2821 tggacttaag acagcctctc aacaggtata taggaaggag ccatatcctg aggaaatgat
     2881 gagacaaaac catattttaa aacagccagc tcttggtcat ccagggcaga ggctggataa
     2941 agagccaaat ccagcctatg atccccaact tccatatgta gaaaaacaag ccagcagaga
     3001 ccttgagcag ccaccataca ggtatgagtc ctcaagctac acagaccagt tttctcggaa
     3061 ctatgaccat cgcctacgat ttgaagaccg agtccctacc tatgaagacc agtggtcata
     3121 ttatgatgac aaacagccct acccaactcg gccctttgat actcagcatc ctcgagactt
     3181 ggactccaga cagcatcctg aagaggcttc agaacgaggc tatttccagc gttttgaaga
     3241 gcccgcccct ctgccatatg acagtagacc acgctacgag cagctgcctc gaacctctac
     3301 tctccgacat gaagaacagc caaccagtgg atatgaggtg cacaacaggt acaggccaga
     3361 agcacagccc tatgctccag caggtcctaa gtcatctgag ccgaagcagt actttgacca
     3421 gtacccacga agttatgagc aagtaccacc accaggattt acctccaaaa caggccatta
     3481 cgagcctctc catggtgctg cagttgttcc tcctctgata ccttcctctc aacataagcc
     3541 agaagttctg ccctcagcta ccaagccaca gcctccgccc ccagccctaa ctgaggaaga
     3601 ggaggatcca gcaatgaaac cacagtctgt gctcaccagg gtcaaaatgt ttgaaaacaa
     3661 aagatctgcg tctctggaga acaagaagga tgtgaatgac actgccagct ttaagcctcc
     3721 agaagtagca tctaaacctc caagtgcttc tcttgttggc cctaaacctg tttctcagac
     3781 tcagtttagt gagcatgaca aaacactcta caggctccca gagcctcaga aacctcaagc
     3841 gaagccacct gaagatattg ttcgatcaaa tcattacgat cctgaagagg atgaagagta
     3901 ttaccggaaa cagctctctt actttgaccg gagaagtttc gagagcaagc ctcctgcaca
     3961 tattcctgct ggccatcact cagagcctgc caagccagtc cattctcaga gtcagccgaa
     4021 tttctctagt tattcttcaa aggggaaacc cgaaactgat gctatggata gatcattcag
     4081 tgagaaacgt tatgatccaa cccaggccat gcctcctcct cctccgttgc cctcacagta
     4141 cagccagcca gttccgcctc tgtccaactc ttctctccac atacattcca aggccgccca
     4201 gagtgaaggc aattccgtat cgttggattt tcagaactca tatatatcca aaccagaccc
     4261 acccccatct cagagcaaac cagcaacttt tagaccacca acccgggagg accctcctca
     4321 gaccttctat ccccagaaaa gtttcccaga caaagcttca gttaatggag ctgagcagac
     4381 tcagaaaacc atcactccag catacaaccg attcacacca aagccgtaca cgagctctgc
     4441 ccggccattt gaacgcaagt ttgaaagtcc aaagttcaac cataatcttc tgccaagtga
     4501 aactgtacat aaacctgaat tgtcttcaaa acctccccct tctccaaaaa ctctcatgaa
     4561 ggctcatagt tccacacagc cgcctgagtt tgacagtgga gtcgagactt tctctgttca
     4621 cacagataag cctaaatatc aaataaataa tatcagcacc atgcctaaag ctgttcctgt
     4681 gagtccttca gctgtggaag aagatgaaga tgaggatggt catactgtag tggctacagc
     4741 ccgcggcatt tttaacagca atggcggtgt gttgagttcc atagaaactg gtgttagtat
     4801 aattatccca caaggagcca ttcctgaagg aattgagcaa gaaatctatt tcaaagtctg
     4861 cagagacaat agcatcctcc cacctttaga taaagagaaa ggtgaaactc tgctgagccc
     4921 cctagtgatg tgcgggcccc atggcctcaa gttcctgaag cctgtggagc tacgcttgcc
     4981 acactgtgcg tccatgactc ctgacggttg gtcttttgct ctaaaatcat ccgactcctc
     5041 gtcgggtgac cctaaaactt ggcaaaacaa gtgtcttcct ggagatccga attaccttgt
     5101 tggagccaac tgtgtttctg tcctgattga ccacttttaa ttcttagagt ctagcagctg
     5161 gactaagcag tgtgaacatg gattgaactt actgaatgga accactctaa tgagtattct
     5221 attttcttag aatttatact gcagttagta gtattaaaca tttgttggaa ctgataaagg
     5281 ttagtgagca tgcccctgaa ccacgatcag aaaacatgct acaagctgtg tgttattgag
     5341 tggagaactg tcaggcattg gctagaggtt caaagatatt ttgctttgta atgatttttg
     5401 tactttttta tggtcactgc ttaacttcac atactgattt ccgttaaaaa taccagccag
     5461 taaatggggg tgcatttgag ttttgttctt tccaaagtac actcaacctt tactatggcc
     5521 ttggcctagc atacacattt attttattat gcatgaggta atgtgcacac attttttaca
     5581 aatgcacctg gaatatataa ccagtgtagt ggatttaaca gaaatgtaca gcagggggat
     5641 ttataacttg gggagggagg ggcaaatgaa gacaattcct tattgtatat gaaaacacat
     5701 ttctcttagg gaaggacacc aaagcatgtg agcccagttc catggccgct gaatctataa
     5761 attaacatat caccacagac atccaaccag caggaatgcc ttaccctcat ggttttcatt
     5821 cttagatcat ttcgctctgt agtactaagt ttttatgagt ttgtgcgtac ctagatactg
     5881 tatcatggaa aagactgagg aaattgtgga cttgatggtt tcggaaatgt gtaaatcacc
     5941 tggaagaaag taatggtgtg acttaaaata tttttttttg acaagggaga gtggttggtg
     6001 gtcttctgtt ctttgggcta tgcatctgag atgtttgatg tgttcaggac gcatgtacat
     6061 aatgcgtgca taccactttt gttcttggtt tgtaaattaa cttttataaa ctttaccttt
     6121 ttatacataa acagaaccga gtttctaagg ctacctttgt attctctcct gtacctcttg
     6181 agccttgaac tttgacctct gcagcaataa agcagcattt ctacacatat aaggtcattt
     6241 ttttaagaaa aagaatgcac agagttgtta catttttaag tgctgcattt aaaagataca
     6301 gttactctag tttgattaaa ttcttgcaaa gtatcccttc tgtaaaattt gtgatacaat
     6361 gctgtgccct aaagtgtatt tttttactaa tagtttatta tggcacatca gcacgatttc
     6421 tgtttagata atacaccact acattctgtt aataatcatt aggtgtgaaa ggatttcttt
     6481 tgtggttatt aaaaatctca aatttctaaa tctgcaagaa taaaactttt taaaataca
//
LOCUS       NM_001437506            5285 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 532 (Zfp532), transcript
            variant 3, mRNA.
ACCESSION   NM_001437506
VERSION     NM_001437506.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.853446.1,
                                           SRR26360194.853551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000018.1  61366137-61366255
            120-229             JAXUCZ010000018.1  61366855-61366964
            230-2583            JAXUCZ010000018.1  61414137-61416490
            2584-2696           JAXUCZ010000018.1  61467135-61467247
            2697-2847           JAXUCZ010000018.1  61469855-61470005
            2848-5285           JAXUCZ010000018.1  61471223-61473660
FEATURES             Location/Qualifiers
     source          1..5285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5285
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc finger protein 532"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
     exon            1..119
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            120..229
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    142..144
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="upstream in-frame stop codon"
     exon            230..2583
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..3342
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 532 isoform 2"
                     /protein_id="NP_001424435.1"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
                     /translation="MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHIKQN
                     AHVDDDSHTPSSSDVGVSVIVKNVRNIDSSEGVEKDGHNPTGNGLHNGFLTASSLDSY
                     GKDGAKSLKGDTPASEVTLKDPAFSQFSPISSAEEFEDDEKIEVDDPPDKEETRANFR
                     SNVLTGSAPQQDFDKLKALGGENTSKTGVSASGHADKNKVKREAESNSITLSVYEPFK
                     VRKAEDKLKENSEKMLESRVLDGKPSSEKNDPAIAAATSSKTKSSSKLSSCIAAIAAL
                     SAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKSPESQNLIDGTKKASLKPSDSP
                     RSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPS
                     EQAASVMASVTSLLSSSASAAVLSSPPRAPLPTAMVTSAVSSAELTPKQVTIKPVATA
                     FLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPA
                     SSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAILNAAAAQPPKKV
                     SRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPASAGITLPMRGYKCLECGDSF
                     ALEKSLSQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILK
                     PVPADQMIVSPSSNTAASTLPSSVGAATHTVAKVQPGLTGAVISAPPSTPISPAMPLD
                     EDPSKLCRHSLKCLECNEVFQDETSLATHFQHAADTCGQQMKKHPCRQCDKSFSSSHS
                     LCRHNRIKHKGIRKVYACSHCPDSRRTFTKRLMLEKHIQLMHGIKDPDVKELSDEVTN
                     EEEVEIKEDAKVPSPKRKLEEPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTE
                     NLLQFHEHIPQHKSDGSSYQCRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGE
                     DSQQENKPSPEDEAAEGAVSDRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAE
                     K"
     misc_feature    2503..2562
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2503..2562
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2518..2520,2524..2526,2530..2532,2536..2541,
                     2548..2553,2617..2619,2623..2625,2635..2640,2647..2652,
                     2659..2661,2716..2718,2722..2724,2728..2730,2734..2739,
                     2746..2751)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2518..2520,2524..2526,2530..2532,2536..2541,
                     2548..2553,2617..2619,2623..2625,2635..2640,2647..2652,
                     2659..2661,2716..2718,2722..2724,2728..2730,2734..2739,
                     2746..2751)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2602..2667
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2602..2667
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2692..2754
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2692..2754
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2962..3024
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2962..3024
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2977..2979,2983..2985,2989..2991,2995..3000,
                     3007..3012,3019..3021,3064..3066,3070..3072,3082..3087,
                     3094..3099,3109..3111,3247..3249,3253..3255,3259..3261,
                     3265..3270,3277..3282,3289..3291)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2977..2979,2983..2985,2989..2991,2995..3000,
                     3007..3012,3019..3021,3064..3066,3070..3072,3082..3087,
                     3094..3099,3109..3111,3247..3249,3253..3255,3259..3261,
                     3265..3270,3277..3282,3289..3291)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3037..3117
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    3037..3117
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    3049..3114
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3049..3114
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3229..3294
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    3229..3294
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    3232..3294
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3232..3294
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            2584..2696
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2847
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..5285
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcagatc agctcctgaa cacaatgcag tcactgagct accacagtgg gatagcagct
       61 tcctcccttc atggcagcca aaagcagagg agcttgcagg aagctaccat cccaacacag
      121 cctgttgact ggggctgctt ttaacccttt cctatttgca gagaatgcaa ccgtgtgaca
      181 gtaactgagc actggtccaa agtcttttca aaaggtcaag gttcacaaga acatctgatc
      241 aaattcatga ccatggggga tatgaagacc ccagactttg atgacctctt ggcagcgttt
      301 gacataccag atatggttga tcctaaagca gccattgagt ctgggcacga tgaccacgaa
      361 agccacatta agcagaatgc tcacgtggat gacgactctc acacaccatc atcctcagat
      421 gttggcgtta gtgtgattgt gaagaatgtt cgcaacatcg actcctctga gggagtggaa
      481 aaagatggcc acaatcccac aggcaatggc ttgcataacg ggtttctcac ggcctcctct
      541 cttgacagct atggtaagga tggagccaag tccttaaaag gagacacacc tgcctcagag
      601 gtgactctta aagacccagc gttcagccag ttcagcccca tctccagcgc cgaggagttt
      661 gaggatgatg agaaaataga ggtggatgac ccacctgata aggaggagac gagggccaat
      721 ttcagatcaa atgtgctgac gggctccgct ccccagcagg acttcgacaa actgaaggca
      781 cttggagggg aaaacacaag caagactgga gtctctgcat caggtcatgc agataaaaac
      841 aaagtcaaga gagaagcaga aagcaattcc ataaccctga gtgtctatga gccgtttaag
      901 gtcagaaaag cagaggataa gttgaaggag aactctgaga agatgcttga aagcagggtc
      961 ctggatggga agccgagctc cgagaagaac gaccctgcca ttgctgctgc cacatcttcc
     1021 aaaacaaagt cgtcctccaa gctctcgtcg tgcatagccg ccattgcggc tctgagtgcg
     1081 aaaaaggctg catctgactc ctgcaaagag cctgtggcca attccaggga agcatctcca
     1141 ctaccaaaag aagtgaatga cagtcccaaa gccgctgaca agtctccgga atcccagaat
     1201 ctcatcgatg gcaccaagaa ggcctctctg aagccgtcag atagtcccag gagcgtatcc
     1261 agtgagaaca gcagcaaagg gtccccatcc tctcctgtgg ggtctacccc agctatcccc
     1321 aaagtccgca tcaagaccat caagacatca tctggggaga tcaagaggac agtgaccaga
     1381 gtactgccag aagtggatct ggactctggg aagaagcctt ctgagcaggc agcgtccgtg
     1441 atggcgtctg tgacgtcact tctgtcatct tcagcatcag ctgcggtcct ctcctcaccc
     1501 cccagggcac ctctgccgac agccatggtt accagtgcgg tttcctctgc agagctgact
     1561 cccaaacagg taaccatcaa gcccgtggct acagcttttc ttcctgtgtc tgccgtcaag
     1621 acagcagggt ctcaagtcat caacctgaag ctggctaaca acacaacggt gaaagccacg
     1681 gtcatctcgg ctgcctctgt tcagagcgcc agcagtgcca tcatcaaagc tgccaatgcc
     1741 atccagcagc aaaccgttgt ggtgccggcc tccagtctgg ccaatgccaa actcgtgcca
     1801 aagactgtgc accttgccaa ccttaacctc ctgcctcagg gtgcccaggc cacctctgaa
     1861 ctccgccaag tgctcaccaa acctcagcag caaataaagc aggcaatact caatgccgcg
     1921 gccgcgcagc cacccaagaa ggtgtcccgg gtccaggtgg tgtcctcctt gcagagttct
     1981 gtggtggaag ctttcaacaa ggtgctgagc agcgtcaacc cagtccctgt ttacatcccg
     2041 aacctcagtc ctcccgccag tgccgggatc acgttaccga tgcgcgggta caagtgcttg
     2101 gagtgcgggg actccttcgc cctggaaaag agcctgagcc agcactacga caggcgcagc
     2161 gtgcgcatcg aagtgacgtg caaccactgt acgaagaacc ttgtttttta caacaagtgc
     2221 agcctccttt cccacgcccg agggcataag gagaaaggcg tggtgatgca gtgctcccac
     2281 ttaatcctaa aaccagtccc agcagaccag atgatagtgt ctccgtccag caatactgct
     2341 gcttccactc tgccgagctc ggtgggagct gccacacaca ctgtcgccaa agtacagcct
     2401 ggcctaaccg gggcggttat ctcagctcct ccaagcacac ccatcagccc agccatgccc
     2461 ctagacgaag acccctccaa gctctgtaga cacagtctca agtgtttgga gtgcaatgaa
     2521 gtcttccagg atgagacgtc cctggccaca catttccagc atgccgcaga cacatgtgga
     2581 caacaaatga agaagcaccc ctgccgccag tgtgacaagt ctttcagctc ctcccacagc
     2641 ctgtgccgcc acaatcgcat caagcacaaa ggcatcagga aggtttacgc ctgctcgcac
     2701 tgcccagact cccgtcggac cttcaccaag cggctgatgc tggagaagca catacagctg
     2761 atgcacggga tcaaagaccc tgacgtaaag gagctgagtg acgaggttac caacgaggag
     2821 gaagtggaga taaaggagga cgccaaggtt cccagtccta agcggaagtt ggaggagcca
     2881 gttttagagt tcaggcctcc ccgaggagcc atcactcagc cactgaagaa actgaaaatc
     2941 aatgtcttta aggtccacaa gtgcgccgtg tgtggcttca ccactgagaa cctgctgcag
     3001 ttccacgaac acatccccca gcacaagtcg gacggctcct cctaccagtg ccgggagtgc
     3061 ggcctgtgct acacgtccca cgtctccctg tccaggcacc tcttcatcgt gcacaagctg
     3121 aaggagcctc agcctgtgtc caagcagaac ggggctgggg aagacagcca gcaggagaac
     3181 aagcccagcc cggaggatga ggccgccgag ggggcagtgt cagacaggaa gtgcaaagtg
     3241 tgcgccaaaa ctttcgaaac ggaagctgcc ttaaacacac acatgaggac acacggcatg
     3301 gccttcatca agtccaaaag aatgagttca gctgaaaaat agccacagaa cttccataag
     3361 aacaatccct gtccacatag gaattgaacg tttttgttac caaaagtttg cagtataaca
     3421 gagttaccag ttctgtctag gctgtggcaa tagactcttt gtcctgccct ctcacctcag
     3481 atgtatccct tcccataagt gttaaggcag tatttgagtt ttaaagagtt tgtatatatt
     3541 taaataacat tttatactct ttgttacatg tttgtatcag tatttggtgg aaaatgtttt
     3601 gagggttttt tttgtgtgtg tatgttagga ttctcttttt ttgtactgtt tctttaaaac
     3661 agagttctta ggggaagttc ctgaattcaa accaaccatt ttgtatgttg agaatttgaa
     3721 tgagttcagt aattacaggc tatcatgcct tttttagtgt ttttaatttt tagaactcgc
     3781 cacataaatt ataggtgatt gtgggtcaca caacactagc aacttttaag tgtcttagca
     3841 ccacactcag cgtgcctgct cctagcaacc gagggctcca aggacagcat cacccagtta
     3901 agggcgtggc ctgagccatc ccagacagtg tgggaagcag ccttacaggt ccctcctttg
     3961 ccatagtagg taaaagaggc caggaatcca gtagggagtg cggtcgtcct taatcccaac
     4021 tggaagaatg aggaagaagg gatccataaa ggggagacag tggagctggg tgaattcgca
     4081 aggtgactta cagggcacaa ggagacaggc tagggaaagg ccagcctgtg gtcaaagttg
     4141 aaagtcatag ttagacctgt cgctctctct gtcaggtttt gtcatggaac tcaccaacct
     4201 ttctagagac acacactaca agagtaccaa gtatttctct ggctcttgat aggaacagaa
     4261 aggcacggtt gacttaaccc tttgctgtct acacagttgg tatttcctgt tccgggtgct
     4321 actgccaaat gttcgggtac ttagtgtcgg gatgcacagc ctcaccaccg acctagcact
     4381 gcagcagcct gtactctgca actggcctga ggagccacca ggcttctaga gtcgtttcag
     4441 caccctctca aggccgcctg actggagcac cgctgaggtg ctcttcgtca catccctgcc
     4501 tagttctctg agaaaactat atattttggt tattgttttg tgtttttcgt tgcattttgt
     4561 atcttgtatt tatctcccga tatgttttgt acttttgttt tcctaaacga ggaaattcat
     4621 ttgtgtacat aaatacttgc atgctaaact gtagtccacg ttcagttccc tgaaaggtct
     4681 tgctgctgtt ggtgcgcacc ctacaccatc gtgactgtat tcagcccatt tcacatgtaa
     4741 ataaaacgag gaacatctgg cccttgagct tcttcaagag agtcattggt gggtctctga
     4801 catcatacag ttcggggagt gactcttttg gggacaggct gcagaatact gcagaattct
     4861 ttccactctg aagaatggct tctcgttctc atcggcgacc agctcactac cctgccgctt
     4921 tctgtcgact gtgtcgacac aatccaaggg tgcgagatgt tcctcagctt gaaatgtaat
     4981 tgctgttacg tgttacatcc gcaccgctcc cgcccccact cgtggtcatg gcactttcac
     5041 acgttcctgc atttgaacct tgcaataagc ctgcgtggcg gccacgcggg tctgtacagc
     5101 ttacagctga ggaagctgcg ctcaggttca gctcttcgcc cgacccctca tagctggtaa
     5161 gtggctttgc atattagaac ccaaatattt cgctctcagt ctagtattct cgctctttgt
     5221 ggctatgtac atattgacag atactcattt attcaacaaa taaagttatg tgcaaaaaca
     5281 ccata
//
LOCUS       NM_001009682            2836 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase-like 2 (Oasl2),
            transcript variant 1, mRNA.
ACCESSION   NM_001009682 XM_222236
VERSION     NM_001009682.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2836)
  AUTHORS   Perelygin,A.A., Zharkikh,A.A., Scherbik,S.V. and Brinton,M.A.
  TITLE     The mammalian 2'-5' oligoadenylate synthetase gene family: evidence
            for concerted evolution of paralogous Oas1 genes in Rodentia and
            Artiodactyla
  JOURNAL   J Mol Evol 63 (4), 562-576 (2006)
   PUBMED   17024523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001009682.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY237116.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               JAXUCZ010000012.1  47382922-47383219   c
            299-587             JAXUCZ010000012.1  47380276-47380564   c
            588-763             JAXUCZ010000012.1  47379484-47379659   c
            764-1005            JAXUCZ010000012.1  47375682-47375923   c
            1006-1162           JAXUCZ010000012.1  47374336-47374492   c
            1163-2836           JAXUCZ010000012.1  47369829-47371502   c
FEATURES             Location/Qualifiers
     source          1..2836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2836
                     /gene="Oasl2"
                     /note="2'-5' oligoadenylate synthetase-like 2"
                     /db_xref="GeneID:304549"
                     /db_xref="RGD:1307351"
     exon            1..298
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="Oasl2"
                     /note="upstream in-frame stop codon"
     CDS             101..1636
                     /gene="Oasl2"
                     /EC_number="2.7.7.84"
                     /note="isoform 1 is encoded by transcript variant 1; 54
                     kDa 2'-5'-oligoadenylate synthase-like protein 2"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein 2
                     isoform 1"
                     /protein_id="NP_001009682.1"
                     /db_xref="GeneID:304549"
                     /db_xref="RGD:1307351"
                     /translation="MDTLPDLYGTVGDSLDYFLEHSLQPQRDWKEEGKDAWERIERFF
                     REKCFCDELLLDQEVRVLKVVKGGSSGKGTALNHRSDQDMILFLSCFSSFKQQARDRK
                     AVIDFIKSKLIHCRKSLAYNITVRQHKEGKRTPRSLTLEIQSRKSNDIICMDILPAYN
                     ALGSFSRDCKPEPEIYENLIRCKGYPGDFSPSFAELQRHFVKSRPVKLKNLLRLVKFW
                     HLKYLRHKYRRAVLPSKYALELLTIYAWEMGTDSSDNFNLDEGFVAVMELLRDYQDIC
                     IYWTKYYDFQNEVVRNFLKEQLKGDRPIILDPADPTNNLGRRGKWELVAKEATYCLLQ
                     LCCVTADRWNVQVSIAHYLRGARDVQVTVKQTGREEWILLTNPHSPIRKLKAKIKKRM
                     NLCGELRISFQEPGGERQPLSGRKTLSDYGIFSKVNIRVMETFPPEIQVFVRYPGGQN
                     KPFAIDPDATILSLWEKIEEDGGPCTEDWVLLFEGEELDDDDNLAELQIKDCDTIQLS
                     RVS"
     misc_feature    185..742
                     /gene="Oasl2"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    185..742
                     /gene="Oasl2"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    order(299..307,314..316,320..328,341..343,347..349,
                     476..481,509..511,560..562,698..700,710..712,719..721)
                     /gene="Oasl2"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(299..307,314..316,320..328,341..343,347..349,
                     476..481,509..511,560..562,698..700,710..712,719..721)
                     /gene="Oasl2"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(302..307,341..343,347..349,479..481,698..700,
                     710..712,719..721)
                     /gene="Oasl2"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(302..307,341..343,347..349,479..481,698..700,
                     710..712,719..721)
                     /gene="Oasl2"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(341..343,347..349,560..562)
                     /gene="Oasl2"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    order(341..343,347..349,560..562)
                     /gene="Oasl2"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    608..1141
                     /gene="Oasl2"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    608..1141
                     /gene="Oasl2"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    1175..1396
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl1_OASL; cd01811"
                     /db_xref="CDD:340509"
     misc_feature    1175..1396
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl1_OASL; cd01811"
                     /db_xref="CDD:340509"
     misc_feature    1412..1627
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 2 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl2_OASL; cd16103"
                     /db_xref="CDD:340520"
     misc_feature    1412..1627
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 2 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl2_OASL; cd16103"
                     /db_xref="CDD:340520"
     exon            299..587
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..763
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1005
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1162
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2836
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtctcct tctccagaga aggctgccgg aagcttctcc cagcattgct gagcagaagc
       61 acagaagatt caatccagag gacaggctga tccagcagag atggatacat tacccgacct
      121 gtatgggacc gttggggaca gtctagacta cttcctggaa cacagccttc agccccaaag
      181 ggactggaaa gaggaaggaa aggatgcctg ggagagaatt gagaggttct ttcgggaaaa
      241 gtgcttctgt gatgagctgc tcctggacca agaagtcagg gtgcttaaag tggtaaaggg
      301 aggctcctca ggaaagggga cggcgctgaa ccacagatct gaccaggaca tgattctgtt
      361 cctgagctgt ttttccagtt tcaaacagca ggcaagagac cggaaggccg tcatagactt
      421 cattaagagc aagctgattc attgtaggaa aagcctggcc tacaacatca ctgtccgtca
      481 acacaaagaa ggcaaaagga cccctcgctc cctgacccta gagatccagt ccaggaagag
      541 caatgacata atttgcatgg atattctccc tgcttacaat gccttgggat ccttttccag
      601 agactgcaaa ccagaacctg aaatctacga gaatctgata aggtgtaagg gctaccctgg
      661 cgacttctcg ccaagtttcg cagagttaca gagacatttt gtgaaaagtc gcccggttaa
      721 actgaaaaac ctcctacggt tggtgaagtt ctggcacctg aagtacctga ggcataaata
      781 tagaagagca gtgttgccct caaaatatgc actggagttg ctgaccatct atgcttggga
      841 gatgggtaca gacagcagtg ataatttcaa tctggatgaa gggtttgtag ccgtcatgga
      901 gctcctcagg gactaccaag acatctgcat ctactggacc aagtactatg atttccaaaa
      961 tgaggtcgtc aggaacttcc tgaaggaaca gcttaagggc gaccggccta tcattctaga
     1021 cccagctgac cccaccaaca acctaggaag aagaggaaaa tgggaactgg tggccaaaga
     1081 agctacttac tgcctgctac agttgtgttg tgtgactgca gaccgctgga atgttcaggt
     1141 atctatcgcg cactacctcc gaggagcgag ggacgttcag gtgacagtga aacaaacagg
     1201 aagggaagag tggattctct tgacaaaccc ccacagcccc atcaggaagt tgaaggcaaa
     1261 gatcaagaag agaatgaacc tctgtgggga gctgcgtatc tccttccagg agccgggagg
     1321 ggagaggcag ccgctgagtg gccggaaaac cctgtcggat tatggaattt tctctaaggt
     1381 gaacatccgg gtgatggaga cctttcctcc tgagatccag gtctttgtga ggtatcccgg
     1441 tggccagaac aagccttttg ccatcgaccc tgatgctacc atcttaagcc tgtgggagaa
     1501 aattgaggaa gatggaggcc catgtacgga ggattgggta ctactgtttg agggtgagga
     1561 gctggacgat gatgacaacc ttgcagagct tcagatcaag gactgtgaca ccatccagct
     1621 cagcagggtc tcctagtctg cctccccaca tcaccccttt actctgacat attcctcctg
     1681 tagcttaaac atcatcatat ccggttgggg atttggctca gtggtagagc gcttgcctag
     1741 caaccgcaag gccctgggtt cggtccccag ctccgaaaaa aaaagaaaaa acaaaacaaa
     1801 acagaacaaa aaaatcatca tatccttctc ttgcttaaaa ccctcctgtg ttttctggta
     1861 acacagggtg aagttcaagt ttcttttcct aacaagagtc ttaaatataa tcccccaccc
     1921 ccaccctgca cactcaatgc acaccagata ctgaatgacc ccgtgagtca cacacagagt
     1981 tccgagggct cccgagtccc agcgagttcg ggtcacactg agtgcaaatg acacacacaa
     2041 aggggctggg gtcacgcccc catcactttg cctcaactac cctttccctc accccagcct
     2101 gtgttctcat cgttctgtga gataccgaat ctcaaagagc agacctcaga tggacagatt
     2161 tctcacctct ccagaaacgt ctcagaagga aaaactaacc tgaaccaggg acccgctggg
     2221 actcagcggg ctctgagcct tccatgtcat ccggcaagct tgagtttgaa aacaacaacc
     2281 tccctcgtgg ttggggattt agctcagcgg tagagcgctt gcctagcgag tgcaaggccc
     2341 tgggttcggt ccccagctct ggaaaaaaaa aataataaca aaaaaacctc gggctggaga
     2401 gatggctcaa cggttaagag cacccgactg ctcttccaga ggtcatgagt tcaattccca
     2461 gcaaccgcat ggtggctcac aaccatctat aaagagatcc gatgccctct tctggtgtat
     2521 ctgaagacag ctacagtgta cttatatata ataaataaat aaatcttaaa aaaaaaaaaa
     2581 gaaagaaaga aaaagaaaac aactacttct ggcccatgca acaggccatg tgatcttgtg
     2641 ttctcgccct ctcccatcat ccccattaga ctcctgggaa tgtgggacct taatcatgct
     2701 gttttcctaa tctatctccc tcatctaatg agacttgatt gtttttttaa tgccttaggc
     2761 cttgtgctct acaaggatac cagtccagta caaatgtttg atttctgctg gttaaataaa
     2821 gaaactaacc aaagaa
//
LOCUS       NM_001437480            3730 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 8, mRNA.
ACCESSION   NM_001437480 XM_063277307
VERSION     NM_001437480.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3730)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3730)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3730)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3730)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3730)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3730)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277307.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1223926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               JAXUCZ010000018.1  48405478-48405798
            322-424             JAXUCZ010000018.1  48472546-48472648
            425-497             JAXUCZ010000018.1  48485845-48485917
            498-1366            JAXUCZ010000018.1  48504584-48505452
            1367-1546           JAXUCZ010000018.1  48507187-48507366
            1547-1660           JAXUCZ010000018.1  48514668-48514781
            1661-1786           JAXUCZ010000018.1  48523111-48523236
            1787-1956           JAXUCZ010000018.1  48526537-48526706
            1957-2049           JAXUCZ010000018.1  48532075-48532167
            2050-3103           JAXUCZ010000018.1  48532658-48533711
            3104-3730           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3730
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..424
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    329..331
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             368..3109
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 2 is encoded by transcript variant 8;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 2"
                     /protein_id="NP_001424409.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAA"
     misc_feature    <1328..1891
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1328..1891
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1409..1411,1415..1417,1427..1432,1439..1447,
                     1451..1456,1466..1468,1481..1483,1508..1510,1514..1516,
                     1520..1522,1637..1642,1649..1657,1661..1666,1676..1678,
                     1697..1699,1724..1726,1730..1732,1736..1738,1748..1753,
                     1760..1768,1772..1777,1787..1789,1796..1798,1823..1825)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1409..1411,1415..1417,1427..1432,1439..1447,
                     1451..1456,1466..1468,1481..1483,1508..1510,1514..1516,
                     1520..1522,1637..1642,1649..1657,1661..1666,1676..1678,
                     1697..1699,1724..1726,1730..1732,1736..1738,1748..1753,
                     1760..1768,1772..1777,1787..1789,1796..1798,1823..1825)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1409..1510
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1409..1510
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1514..1726
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1514..1726
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1730..1825
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1730..1825
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1898..2029
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1898..2029
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            425..497
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1366
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1546
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1660
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1786
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1956
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2049
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..3103
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3730
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggcgttc tgcttgctgc tacctcggat cgtcccggag gcggggatgg gctgtgccga
       61 ggctcctaag agctcccagg gaggggcaaa ggcttggtga tagctacact agtaaccaga
      121 acaataacaa acgtgaaggg gatgccgggt ggtgtcgcta cccgaaggga gcccctggcc
      181 catcagcccc gcggcgccta ggctgccccg tccagcttca gctcctcctc ccggcgctgt
      241 ccggcgtccc gggattatcc acgtcctggg gaaggcttct ttcctgaccc tctcagtggc
      301 ggtgactttc ctttgcaggt ggatattata aatattcgac cttactcaaa atgtacaaag
      361 aagaataatg gaagcccctg aatatcttga tctggatgaa atcgacttta gtgatgacat
      421 ttcttattca gtcacatctc tcaagaccat cccagcactg tgcagaagat gtgactcaca
      481 gaacgaagac agaccagttt ctagctctag ctggaattgt ggtgtctcaa ctctcattac
      541 aaacccgcaa aagcccactg gaatcgctga tgtatacagt aagttccgcc cggtgaagcg
      601 agtttctcca ctgaaacatc agccagagac tctggagagc aatgaaagtg acgaccagaa
      661 gaacaataca gtggaatacc agaaaggggg ggagactgac cagggccccc agcctgagga
      721 gctcagccct gaagatggag tcggaggctt gccaggcaag ggctcagagc ccagccaggc
      781 actgggtgag ctggagcact atgacctcga catggatgag attctggatg tgccttacat
      841 taaatccagt caacagctgg ccccgctcac caaggtgact tcagaaaaaa ggattttggg
      901 tttatgcaca actgtcaatg gcctctctgc caaaacctgc cctattgtaa gcgctgagac
      961 ctccacaccc aacatggctc cattgtgtgt tctttctcct gtgaaaagcc ctcacttacg
     1021 gaaagtaccc agtgtcctcc gggaccagca caagctccct gcggaagaat cggagaactc
     1081 acccgctcct ggtaaatgcg gccctgcatt tgaatcagaa aaccacagta aggacttctt
     1141 aaacaaggtc tttagtgatc cccatagtcg gaaagctgag aagtctgggc cagactgcaa
     1201 gctcaggccc ttccgcctgc agacctcggc agcaggagcc aaaccagagg agcaggtcaa
     1261 cggcgtgagc tgggccagtg cccaaggcgc agaagaaagg actgagtacc tgcagaaagt
     1321 aagaagcata ctgaacattg tgaacgaagg gcagatatcg ctcttgccac acctagctgc
     1381 agataatctg gacaaaattc acgacgagaa cggaaacaat ctgttacacg ttgctgcatc
     1441 aaagggccat gcggaatgtc tgcagcacct cacgtcgctg atgggcgaag actgtctgaa
     1501 tgaacggaac gcagagcaac tgactccagc gggcctggcc atcaagaatg gtcagctgga
     1561 gtgtgtacgc tggatggtga gtgagacgga agccattgcg gaactgagtt gttccaagga
     1621 tttcccaagc ctaattcatt acgcaggctg ctatgggcag gaaaagattc ttctgtggct
     1681 tcttcagttc atgcaagaac aaggcatctc attggatgaa gtagatcagg aaggcaacag
     1741 tgctgttcat gtcgcttcac aacatggcta ccttggatgc atacagaccc tggtggagta
     1801 tggagcaaat gttacgatgc agaaccacgc tggggaaaag ccctcccaga gtgccgagcg
     1861 gcacggccac accctatgtt cccggtacct cgtggtggta gagacctgta tgtcactggc
     1921 ctcacaagtg gtaaagttga ccaagcagct aaaggagcag acagtggagc gcgtcacact
     1981 gcagagtcaa ctccaacaac ttctggaagc ccagaaatca gagggcaagt ccctcccatc
     2041 ttcacccagt tcaccctcct caccagcttc tagaaagtcc cagtggaaaa ttctagatgc
     2101 agatgacgag tctacaggca aaagcaaact gggaacccag gagggaatac aagtccttgg
     2161 aaacttatcc agcagggcta ggaccaaagg aaaagacgaa gactctgata aaatcctacg
     2221 tcagttattg gggaaagaaa tatcagagaa tgtctgcacc caggaaaagc tgtcattgga
     2281 attccaggat gctcaggtat cctctaggaa ttcgaaaaaa atacctctag agaagaggga
     2341 actgaagcta gctagactgc ggcagctgat gcagagatct ttgagtgaat ctgacacgga
     2401 ttcaaacaac tctgaggacc ccaaaaatac tcctgtgaaa agagtggaca gacctagacc
     2461 acagcccatt gtggaaagtg tggagaatat ggacagtgca gaaagcttac acctgatgat
     2521 aaagaaacac tctgtggcat caggacgcag gtttcctttt ggtatgaagg cctccaaatc
     2581 cctggatggg cacagcccat ctcccacttc agagagcagt gaaccagatt tggactccca
     2641 ttgcccgagc ctgggaatga ctcctccaac ccaaccttct acagaagcca ctcagtgcag
     2701 tcctgacagt gccactgccc agaaagttgc tacaagcccc aagagtgccc tcaagtctcc
     2761 atcatccaag cgccggacat cccaaaactc aaaactgaga gtgacctttg aggagcctgt
     2821 tgtgcaaatg gagcaaacta gccttgaact aaatggagaa aaagacaaag agaggggcag
     2881 ggccccccag aggactagtg agtcaggaga acaaatgaaa aggccttttg gaaccttccg
     2941 atccatcatg gagagtttaa gtggtaatca gaacaacaat aataactacc agccagccag
     3001 ccagctgaag acctgcacac tacccttgac gtcacttgga aggaagacag cagatgccaa
     3061 gggaaaccct gtgagccctg ctagcaaagg aaagaataag gcagcttaat gacatcaaaa
     3121 gaaacacgaa gaaaacttac aacgtaaagc acattgctga accagagcca aaggaactct
     3181 tcttataaat tactcttagt atgagtctca cacatgccct ctggccacca ttgggagtta
     3241 atggactgtg gcaatcagac catgagaaca acacctcacc agcgagcaga atatctggat
     3301 gccttaaatt tataatatga gacttgttat aagatacatt ttggaccata tctgtacata
     3361 gaacttgttt gatttctttt ttaatatgct gtttgaaaac atgatcgggc aatgtatgca
     3421 ttgacacatt ggacatttga ttgagtcgac cttcttgaag cacatccacc agcacctgac
     3481 acgactagtg tttttgtgaa ttgcatgagg atttgctgat gttgattaga tgttcacctt
     3541 ctttgtaaca agggcagctg tggctcagct cagtgaggcc aggtcactgg ttttattttc
     3601 tgtccagtgt gtttttctgt catttctact tttttaataa agaaaattaa acatttgtaa
     3661 cagcagactc tgggcgtggg gggcagggca tctactttct aataaatctg tgaagctctg
     3721 atttctaaaa
//
LOCUS       NM_001008362            7507 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 655 (Zfp655), transcript
            variant 2, mRNA.
ACCESSION   NM_001008362 XM_341034
VERSION     NM_001008362.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7507)
  AUTHORS   Houlard,M., Romero-Portillo,F., Germani,A., Depaux,A.,
            Regnier-Ricard,F., Gisselbrecht,S. and Varin-Blank,N.
  TITLE     Characterization of VIK-1: a new Vav-interacting Kruppel-like
            protein
  JOURNAL   Oncogene 24 (1), 28-38 (2005)
   PUBMED   15558030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001008362.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085937.1, SRR26643297.39250.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000012.1  14488258-14488345   c
            89-226              JAXUCZ010000012.1  14486463-14486600   c
            227-331             JAXUCZ010000012.1  14475787-14475891   c
            332-7507            JAXUCZ010000012.1  14467958-14475133   c
FEATURES             Location/Qualifiers
     source          1..7507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..7507
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="zinc finger protein 655"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
     exon            1..88
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="upstream in-frame stop codon"
     exon            89..226
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1716
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="isoform 2 is encoded by transcript variant 2; vav-1
                     interacting Kruppel-like protein; zinc finger protein
                     205-like"
                     /codon_start=1
                     /product="zinc finger protein 655 isoform 2"
                     /protein_id="NP_001008363.1"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
                     /translation="MEEITSQEAAESPRVQFQSLESQSECLSPELRFLRDTEMEQGYT
                     DGFPISKPDGISQREQDLQVFDLETQNREGVRNDCSDGETREENKLLIPKRKISEEVH
                     SYKVRVGKFKQDIAQVPETREAYKSEDRLERLQEILRKFLFLEREFRQITISKKTFSN
                     EKNTEPEKSFSLDSTLDTDQRVLRIQTIDDSKYDMNFNQNPAVGEQEPINLTENFQNT
                     DYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQRIHTREKPYKCKEC
                     EKSFSQSSSLSRHKRIHTREKSYRCEASDKSCDASDKSCSQSSDVLQHKKVHAKAKSY
                     KCGTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTSYLVEHQRLHHQEKSYEYD
                     ECGLAYVKQQGIRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEKLHECNERGKAFSQ
                     TSCLSQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVFDCDAWEENFSQRA
                     HLIPHERAHTKEKPYECNELGETFSQVQASFNM"
     misc_feature    799..>1671
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    799..>1671
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    823..885
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    823..885
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(838..840,844..846,850..852,856..861,868..873,
                     880..882,1027..1029,1033..1035,1045..1050,1057..1062,
                     1069..1071,1111..1113,1117..1119,1123..1125,1129..1134,
                     1141..1146,1153..1155)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(838..840,844..846,850..852,856..861,868..873,
                     880..882,1027..1029,1033..1035,1045..1050,1057..1062,
                     1069..1071,1111..1113,1117..1119,1123..1125,1129..1134,
                     1141..1146,1153..1155)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    907..1074
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    907..1074
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    919..969
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    919..969
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1096..1158
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1096..1158
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1177..1239
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1177..1239
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1192..1194,1198..1200,1204..1206,1210..1215,
                     1222..1227,1234..1236,1342..1344,1348..1350,1360..1365,
                     1372..1377,1384..1386,1426..1428,1432..1434,1438..1440,
                     1444..1449,1456..1461,1468..1470)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1192..1194,1198..1200,1204..1206,1210..1215,
                     1222..1227,1234..1236,1342..1344,1348..1350,1360..1365,
                     1372..1377,1384..1386,1426..1428,1432..1434,1438..1440,
                     1444..1449,1456..1461,1468..1470)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1327..1389
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1327..1389
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1411..1473
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1411..1473
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1579..1641
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1579..1641
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            227..331
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            332..7507
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcgagagt ggccccggaa aggctggtga gactcagcga ggagcgtctc cgtgacggga
       61 cagtctctag gcccgcctct ccacctgggg atggaggaaa taacatccca agaagcagca
      121 gaatcaccaa gggtccagtt tcagtctttg gagagccagt ctgaatgtct ttccccagag
      181 cttcggtttc tgcgggacac agagatggag cagggataca ctgatggatt tccaatttcc
      241 aagcctgatg gaatttctca gcgggaacaa gatctacaag tctttgatct ggaaactcag
      301 aatagagaag gcgtaagaaa tgactgttca gatggagaga ccagagaaga aaacaagctg
      361 ttgattccta agcggaaaat ttcagaagaa gtacattcat acaaagtgag agtaggaaaa
      421 ttcaaacaag atattgctca agttcctgag accagagagg cttataagtc tgaggacaga
      481 ttagaaaggc tccaggagat tctaagaaaa tttctctttc tggagagaga gtttagacaa
      541 ataacaatca gcaagaaaac tttcagcaat gagaagaaca ctgaacctga aaaaagcttc
      601 agtctagact ccacacttga tacagatcaa agagttctta gaatacagac cattgatgac
      661 agtaaatatg acatgaactt caaccagaac ccagctgttg gcgaacaaga acccataaat
      721 ctaacagaga attttcagaa tactgactat aaggaaagct taatggatct gtcccacctt
      781 aataaatggg agagcatgcc taccactgac agatcctata aatgtgatac atgtggaaaa
      841 accttccatc aggcctcagc tcttactaga catcagagaa tccacacaag agagaaaccc
      901 tacaaatgta aggaatgtga gaaatctttt agtcagagct caagtcttag tcgacataaa
      961 agaatacaca ctagagagaa atcctacaga tgtgaagcat ctgataaatc ttgtgatgcc
     1021 tctgataagt cttgtagcca gagctcagat gtgcttcagc ataagaaggt tcatgccaaa
     1081 gccaagtctt acaagtgtgg gacctgtgaa agagtcttca gccgaagtgt gcatcttact
     1141 cagcatcaga gaacacataa ggacacggcc tgtaaatgca ctgtgtgtgg cagtgacttc
     1201 tgccacacct catacttagt tgaacatcag agactacatc atcaagagaa gtcctatgaa
     1261 tatgatgaat gtgggctggc ctatgttaaa cagcaaggaa ttcgtttccg agaaaagccc
     1321 tactcgtgta atgaatgtgg gaaagacttt agattgaatt cccatcttgt tcagcatcaa
     1381 agaattcaca caggagaaaa actgcatgaa tgtaatgagc gtgggaaagc tttcagccag
     1441 acctcctgcc ttagtcagca tcataaaatg cacaggaaag agaaatcata cgaatacaac
     1501 aattatgagg aaagtttcag tcacaattct gatcttactc tgcaacaaga agttcccatt
     1561 agagagagag tctttgattg tgatgcatgg gaagagaact tcagtcagag agcgcacctc
     1621 atcccacatg aaagggcgca taccaaagag aaaccttatg aatgcaatga acttggggag
     1681 acgtttagtc aagttcaggc ctcattcaat atgtgagaac tgagaccagg ggaagtcaca
     1741 tatgtactga atgtgataat gtcttcagtc atagcttagc ccttggtcag tatcagagaa
     1801 ttaataccag agagaaaccc gctgaatgtg atgaatattg ggaagttttt ttggtgttaa
     1861 attcttcatt ggctcctgta aatcagtgct agaatatata gactatggta cattcttcag
     1921 attattttca taccttagtc acagttgggg aatttgtact ggagtaaaat tccactgtca
     1981 aatgtgaaaa agccatcagt caactacctt gttggttcag tgtcaaattt gtgccatgca
     2041 taaagcctgt gaggatatag gtgtgtatgt gaggaaactc aagtcatacc ccagtgcttg
     2101 ctcacattga agaatctaaa cccttgaaca gtctataccc aagaagtcat ttgggtgtag
     2161 taaatgtggc atatctgtga gcacgggtcc atctattgtc agaatgtacc agatgtgaat
     2221 ctggatatga tgtaaatgct aagatcagaa catctgcacc agatgagact gatagaatgc
     2281 aaacagtgaa atttaaccac tgtattttca ggccttatcc agtatctcaa agtattagaa
     2341 aatggttact gctctgtata attattccta tttagtctca gtctttttac tgcagaataa
     2401 ctgaacccag aagataattg gtgaacgaag tcattttctc acagtatcct ttaataagta
     2461 ttctaagtag gtacgagtat tttatttaca ggactccttt gagtggattt attttaattc
     2521 ggcctacata cattaaaaca cttcttttct ttgaaatcga ttcttgttca cagtttacgt
     2581 aggatgctgc taatgcgctg tgctcactta gcttctggag aggagctcaa tgagccttct
     2641 ctgttcttgg cctgagtgct ctccaaagga gactcagcct attcttttct gaggacccta
     2701 catgttactg tttctgtagc cacaccttgg gcttccagtt gatttctgca ttctccttgg
     2761 cagccttaaa tggtgttctg gttgttagct tctcaccagc tgataaagac ttacttctac
     2821 atcagccatc cataagtttt ggaggattca gtcttcctga gtttgtggca ggcacccaaa
     2881 cacttgcaag tgatgtccaa tttttagctt gtttgcatcc acagcccttt aaatgagatg
     2941 acaaggacat cagggagcca gtaagactta tgttggccta gctacatttc attcagtgcc
     3001 tactttgcat gtatgtgtat gtttagaatt cttttatatg cctatattga aggccaacaa
     3061 aatgctcagg tctgcttttg atagggaaac aaagaacaca caaatcagaa taaggaaata
     3121 gagccttcca atgaagatgt tgctgttagt gatgtatcta gacagtattt caagagcgtg
     3181 gcaggtccgt tcctggtcaa accttaatca ttaggattgc ttctttatct gttccccctc
     3241 tactcccttc atcaagccag ggtagtattt tgaagtgtag acctttgtgc ataattgttt
     3301 gtgcactgcc atacttttgt gttgggatgc agcctttgcc gcccaggctg gccttgaatt
     3361 cctgggttca cacaaatttc ctgcctccca agtagctggg attataggca tgcgctcctg
     3421 tgcctggatt ttatttttgt attttaatag catctgcagg ccatttaaag gatcatgtct
     3481 attttgattt atagaagtga tcacaggtgt tgagttcagt gccctatata ctacatagag
     3541 ttcatgattc tttacatgat gtcaaagcat ttgttttcat cttaaaataa catcttgtga
     3601 ataagaaaag tgttatttaa aattctagtt gtcaatcaag cagttgaggc tttcatagtt
     3661 cagatgtcat aatgttcact agggatcctc aaccaatata taaaatatgc tgctcactct
     3721 gtaaaccttg tggctaacct aggataggga tagtcctacc actgtatttt acttctttgc
     3781 catcagcaag catagtgtct catcagggca agaaaattaa catatatcaa attgatctaa
     3841 atgtaaaagc aaatgaaaaa tgcatgtttt tctgtccctg tcaaacatgt atactcttac
     3901 tttatagcga ccaatagtca cttctggtga ctgaggcaga ggatttgatt catccctaag
     3961 tagcagaatc tgtaaaaatc acatgtatgc atttgggtta ggaacgtgct tttgtatttc
     4021 tacttgaata aaggtgtgtt cagcgctctt agactctttg ttttgaacca agtctgtagg
     4081 ccccaggcag aagctctggc accttggaat tcttcaccgt gcctgtccct agctccttta
     4141 tgatactcac aagagtgatt cgttctctat tgatgcctag cttccctttc cacagacctc
     4201 tgcagccagt taggttgagt agttttgtat tttagattta attaaaatgt ttatgaatgt
     4261 ttgcctgcat gtgcatgtgt gtctggcatt catagaagac agaagaggac atcaggtccc
     4321 ctgaaactgg agttagagag acatttgagt gggttctgaa atcactgctg ttctctgcaa
     4381 gagcaggcag tgttcttaac tgcggaacca actctcaagc cccaggaatg aatgttggtt
     4441 caggtgggat gctttagtac ataaaataaa atcaaacaat gtgtgatttc aataacgctc
     4501 taagaatgtt ttggtaggta aagtaaattt taaaaaagaa tgccaaaatc gtttttgaag
     4561 taacttgtca gtttaagtag atacttagtt ggtgtagtga cagtatgagt ttgtattaat
     4621 taagcttttg gtcttagggg aggaaaagaa gaaatctatt agctggacag ttagttcatt
     4681 tgtcttcatt aacctgtgtg catactttca cgtacacatt caagctttca ccacagttct
     4741 gcatgagagc ttggcttcgc aaaaggctaa agggttttag aacaagttaa tgtctgatga
     4801 aaactgatta atggccgatt cccaggtgac agggtttttg gaagcttttc ctacggtatc
     4861 agtactgtta gcttcagctg atcatactgg cttccagagc tgatgtcaga gttggtttga
     4921 tttggtttga gaccggacat ctctgtatat atccctgact gttctggaac cggctatgta
     4981 gaccaggctg tagttcacct gcctcctaag tgtcaccacc acccagcaga agagagtatc
     5041 ttaaagtaat ccgtggactt agggtaacac tgatgtaatg agttaacagg tcaaaccctc
     5101 agattttcta tctcctgccc agatatccct gccccatcat tagtttccct gttcatttct
     5161 cagcattcta aattaattct tagctttttc tgttagccaa actagctgat ggacatagag
     5221 ctcttgacct gaagcaaaat aaataacagg aagaagcaag cttgattcct ggggcatgtg
     5281 aaagaaagac ttaaaatgta gggagccctg gaagagtgtt agaagaggta gagtgtccag
     5341 tgcttatgac cgtcttggtt agtgttctaa tttagagaag aaaatgttta actggaggct
     5401 tgcttacaat ttcagaggat aagttcatga tcatcatggc cgggaacatg gctgccggta
     5461 agaccaggca tgtaactgag agcttatatc ctgatcttca ggcaggaggc agaggaattg
     5521 agctgaaaat gtgcttttaa agtctcaaaa ctcactccct tccctcagtg agataccgcc
     5581 aacaaggcct cattagaatc ttccctaaac tgtctacaat caaccaaaca atcagatatg
     5641 tgagccctac gggccattct cattcaaacc accacactga aaacaggatt tttttttttt
     5701 tttttttttt ttttttttaa agacaaggtt tcactttact gccttggctg gcctggaact
     5761 gtgatatgcc cacccttgtc tcctaagtgt tgggattaaa ggcaaggttc tttatgtgtg
     5821 agtgagtgag tgcctgcatg atgtctgtgc gtcatgtgca tgcaatgttt gtggaggact
     5881 agatggtgtt ggagttccta gagttactag tcaattgtga attgccatgg tcctgtgaat
     5941 tgaatgttca ttttttaaat atttttttta ttccttgaaa atttcacaca tatgatgctt
     6001 tgacaacatg accattttgt aagcaatact aggttcttgg gcctatgacc tcccttactg
     6061 tgaacaagtt tgcagtagta ggcataaatt cacatgaagc agcctcagat ctaaccagaa
     6121 agtggcaaga gtatagcatt ttaaagtggg aataagggga atctcgaggg gaagaatcct
     6181 taccctagaa aatggatgta agcagttgaa caccctgggt ctccatacca agcttcatta
     6241 ggcaaatgct atactactaa gctacatttc catccccacc taggtctatg gtagttaaaa
     6301 ggaggcccca gttagtcact tcagcaaagt atgacactga cacgtctaaa aatgtagctc
     6361 cacccatcgg acttacctag ttgttaggtg tgtggtattg gtgctagcca gagtgacaaa
     6421 ctgatctaaa attaatccat agatttaaga ggactgcgtt attaatgcag tgctttggaa
     6481 gtagacatac ttaggttttg ctcaactcaa gtgtcacttg aggttttata taacttgcct
     6541 atgcaataaa agcatagtga aaggtgaatg taggggttgg ggatttagct cagtggtaga
     6601 gcgcttgcct agaaagcgca aggccctggg ttcggtcccc agctccgggg gggggggggg
     6661 ggggaagaac caaaaaaaaa aaaaaaaaaa aggtgaatgt aaaaggtacc agtcaatagc
     6721 aaatgctcag ttagttcagg ggccagtgaa gtggttcact aggtaaggat gcttgctgcc
     6781 aagcctggtg atcttaattt catcactggg ttctacaagt aaccctttaa cccccacatt
     6841 cttgcaatgc acagcacacc aaaatacgaa tttttaaaat tttacatttt aaaaagtggt
     6901 gcttggaaga tggcataagt gattaagagc atttctttcc aggttcagag cctgggaagg
     6961 ctgacttcca tggtcagtgc acacatgtga tacatatagg caatacacca tatgcataaa
     7021 ttaaatcttt ttgttggttt ttgtccaaga cagggtctta atattagctc tggctgtcct
     7081 ggcactcaca gtgtagatca gggaggcctc aaactctcaa gtgctgagat taaacgtgta
     7141 ctacacacag caagaactga gtttaagggg ctggagagat ggttcagccc ttaagagtgc
     7201 tgactgctct tccagaggtc ctgagttcaa ttcccagcaa ccacatggtg gctcacaacc
     7261 atctgtaatg aggtctgatg ccctcttctg gcctgtaggc gtacatgcag gcagaaagct
     7321 gtatgttgta tacataatat ttttttttgt tttttgtttt tttttggttt tttttttttt
     7381 ttttcggagc tggggaccga acccagggcc ttgcgcttcc taggtaagcg ctctaccact
     7441 gagctaaatc cccagcccca tattgttttt aaaaaaaaaa aaaaagaact gagtttaagt
     7501 cccagca
//
LOCUS       NM_001437445            1874 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 2, mRNA.
ACCESSION   NM_001437445 XM_006229015
VERSION     NM_001437445.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229015.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2871944.1,
                                           SRR26643293.2999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-702             JAXUCZ010000001.1  104572249-104572332
            703-989             JAXUCZ010000001.1  104572931-104573217
            990-1184            JAXUCZ010000001.1  104574234-104574428
            1185-1358           JAXUCZ010000001.1  104574810-104574983
            1359-1494           JAXUCZ010000001.1  104576616-104576751
            1495-1694           JAXUCZ010000001.1  104577665-104577864
            1695-1874           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1874
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1851
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 2 is encoded by transcript variant 2; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     2"
                     /protein_id="NP_001424374.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALL
                     EEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEP
                     PRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQE
                     ALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLR
                     SELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQ
                     LLERALTPLVDEVKQKGLAPACPSCQRLHKKILPSPVSPAAPTLLSPGAGAPGLGQTR
                     QGRGPELHPSAGPRRSRSGQEPTADGQDEAGVRTEAEGMGGGEKVATLDYMHLKMCSL
                     HDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ"
     misc_feature    187..1848
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1848
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..989
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1184
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1358
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1694
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1874
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaagga gaactgccgc aaggtgaccc gttcagtgga agacgctgaa
      661 atcaaaacca atgtcctgaa gcagaactct gccttgttgg aggagaagct aagatacctc
      721 cagcagcaac tgcaggatga gacgccccgg agacaggagg ccgagttgca ggagctggag
      781 caaaaactag aggctggcct ctcccggcat ggcctaggcc ctactactcc cattcagggc
      841 tgctccggtc ctcctggtag cccggaggaa cccccgcggc cgcgaggcct gccctccaat
      901 ggctggggca tggcaatccg cgcaggggag ggaccctcgc tgagcgagca ggagttgcag
      961 aaggtctcca gcggcctaga ggagctgagg agggaggtgt cctcgctggc agctcggtgg
     1021 catcaggagg agggggcggt gcaggaggcc ctaaggttgc tgggaggcct gggcggccgt
     1081 ctggatggct ttctgggcca atgggagcgg gcgcagcggg aacaagcaca gtccgcacgg
     1141 ggtttgcagg agctgcgagg acgagcagat gagctgtgca ctatggtgga gaggtcagca
     1201 gtgtctgtcg cttcactgag gagcgaactg gaggcactgg gcccagtaaa accgattctg
     1261 gaggagctgg gacggcaact tcaaaactcc cgaaggggac ctgaccatgt cttgaacttg
     1321 gatcgtcctg cccaaggtcc ctgtcctcga tgtgccagcc aggggcagca gttatccacg
     1381 gagtccctac agcagctgct ggaacgtgcg ctgaccccac tggtggacga agtgaagcag
     1441 aagggtctgg ctcctgcctg ccccagttgc cagaggctac acaagaagat tctgcccagt
     1501 ccagtaagcc cagcggcgcc tacactcctc tccccaggag ctggagcgcc aggccttggc
     1561 caaacacgtc agggcagagg ccctgagctc cacccttcgg ctggcccaag acgaagccgt
     1621 tcgggccaag aacctactgc tgacggacaa gatgaagccg gagtgaggac ggaggcagag
     1681 ggcatgggag gaggggagaa ggtggccact ttggactata tgcatttgaa gatgtgttcc
     1741 ctccacgacc aactcagcca cctgccactt gaggggtcca caggggcaat ggggggagga
     1801 agcactggag gggctccccc taaacgtggg ggtccaggct ctgaacaata aatggcctct
     1861 catgctggca tgaa
//
LOCUS       NM_001107397            3542 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 like 4A
            (Epb41l4a), transcript variant 1, mRNA.
ACCESSION   NM_001107397 XM_001060647 XM_006254583 XM_226060
VERSION     NM_001107397.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3542)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_006254583.5, NM_001107397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.62223.1,
                                           SRR26643294.56980.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1175              JAXUCZ010000018.1  25888201-25889375   c
            1176-1280           JAXUCZ010000018.1  25802641-25802745   c
            1281-1332           JAXUCZ010000018.1  25773271-25773322   c
            1333-1411           JAXUCZ010000018.1  25768091-25768169   c
            1412-1509           JAXUCZ010000018.1  25762381-25762478   c
            1510-1630           JAXUCZ010000018.1  25761136-25761256   c
            1631-1718           JAXUCZ010000018.1  25759154-25759241   c
            1719-1807           JAXUCZ010000018.1  25756917-25757005   c
            1808-1871           JAXUCZ010000018.1  25756320-25756383   c
            1872-1963           JAXUCZ010000018.1  25743152-25743243   c
            1964-2041           JAXUCZ010000018.1  25741649-25741726   c
            2042-2163           JAXUCZ010000018.1  25736039-25736160   c
            2164-2254           JAXUCZ010000018.1  25715494-25715584   c
            2255-2338           JAXUCZ010000018.1  25711524-25711607   c
            2339-2452           JAXUCZ010000018.1  25710913-25711026   c
            2453-2500           JAXUCZ010000018.1  25708322-25708369   c
            2501-2578           JAXUCZ010000018.1  25707400-25707477   c
            2579-2698           JAXUCZ010000018.1  25694243-25694362   c
            2699-2746           JAXUCZ010000018.1  25686822-25686869   c
            2747-2815           JAXUCZ010000018.1  25685951-25686019   c
            2816-2926           JAXUCZ010000018.1  25681986-25682096   c
            2927-3008           JAXUCZ010000018.1  25681789-25681870   c
            3009-3542           JAXUCZ010000018.1  25680164-25680697   c
FEATURES             Location/Qualifiers
     source          1..3542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3542
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="erythrocyte membrane protein band 4.1 like 4A"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
     exon            1..1175
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1053..1055
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="upstream in-frame stop codon"
     CDS             1077..3143
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythrocyte protein band 4.1-like 4a; band 4.1-like
                     protein 4A"
                     /codon_start=1
                     /product="band 4.1-like protein 4A isoform 1"
                     /protein_id="NP_001100867.2"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
                     /translation="MGCFCAVPEEFYCEVLLLDESKLTLTTQHQGIKKSTKGSVVLDH
                     VFRHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAED
                     PCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQLGAYAIQAELGDHDPCKHTAGYV
                     SEYRFVPDQKEELEESIERIHKTLMGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENK
                     SEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEAR
                     SKTACKHLWKCSVEHHTFFRMPETESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLS
                     IQLPRPNQNVVRSRSKTYPKRVAQTQPAGSNSINRMTANLENGENEGTTKIIAPSPVK
                     SFKKAKNENSPDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPCTRQRNLSCGSDN
                     DSSQPMRRRKAHHSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRIRQENDM
                     VDSAPQWEAVLRRQKEKNQVDPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGL
                     SEEQLKEIPYTKVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVP
                     PLPVTRSSDAQGSGGSTVHQRRNGSKDSLIEEKSQLSTTNLAGKHTAKTIKTIQAARL
                     KTDVTG"
     misc_feature    1113..1709
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1113..1709
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1695..1964
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    1695..1964
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    order(1719..1721,1770..1772,1776..1778,1794..1796)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1719..1721,1770..1772,1776..1778,1794..1796)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1806..1808,1821..1832,1929..1931,1941..1943,
                     1950..1955)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1806..1808,1821..1832,1929..1931,1941..1943,
                     1950..1955)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1929..1964
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1929..1964
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    2007..2141
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     misc_feature    2007..2141
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     exon            1176..1280
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1332
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1411
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1509
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1630
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1718
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1807
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1871
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1963
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2041
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2163
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2254
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2338
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2452
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2500
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2578
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2698
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2746
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2815
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2926
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3008
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3542
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacctgca ggcacccagc cagactgacc acctccgccc cgccctccgc ccccggctga
       61 gaccccgccc tgaagggggg cgctcgggtc accgtcccgg ggctatccag cttcagatcc
      121 gaggcttttt gccgacaccc cgggccggga cccgctgtac ctgggctgct ccctccaggg
      181 ccccgccctg cgcgccacca agaactttcc ctggagcctc ggaggcctgg cgccccgggt
      241 tctgccgcgc cgcccgcagg tcctcagaca cccggctttt ccaggacgtt cggggaagga
      301 agcttgaact tggccatctc cgcgggatga gttcggggac cttcggacag aagctacagg
      361 ccgcgacaag ctgacctccc ccggttggtt tcctggagcc ctggtcggtc cccgggcagt
      421 gagagtggcg gagggagtgg cgaccttcgc cggtagccct gcgtcccagt cctggtcacc
      481 ctcgacacaa aagagaagct gagcgctctg gactctgcct tccctgttag gggctgcggg
      541 gcggggtcgg cgctggaagt gcgcgcccgg cgaggactcg ggagctgcgg ctggggaatc
      601 gctccagtgc tagcgttggg ctggcgctgc ggagtaccga ggggcatcag agtccaggga
      661 aggtctggag ggctcgtccc gcccttttcg tgtctcgggt cggcggacct tagccaggtg
      721 attcttgttg tcctcaggtc gccgccccat tcttcagaag aggagctgct gccgcaggat
      781 gcgcggggac gcgccacccc tggttcccag ttctgcggac gcttctcggg cgactccggg
      841 ctcttgacgc cccgaggcgc gctcgccctc ccgccttcgc tgtccgagcc tctcggggtg
      901 ccttcggctc accatagaac cccagacctt accctcaccc ggggggcccc acccagaccc
      961 gcgcctctcg ccctctacac ggcgcgcaca ataaattaat gcttcgcgct tgaggggagg
     1021 cggcggcggg cgccgcggtc gctgctctcg cctgactgga gacgctttca gccgacatgg
     1081 gctgtttctg cgccgttccg gaagaatttt actgcgaagt tttgctcctg gacgagtcca
     1141 agctcaccct caccacccag caccagggca tcaagaagtc aaccaaaggt tccgttgtcc
     1201 ttgaccatgt tttccgtcac gtaaacctcg tggagataga ttattttggt ctgcgatact
     1261 gcgacagaag ccatcagaca tattggctgg atcccgcaaa aactcttgca gaacacaagg
     1321 aactaatcaa cactggacct ccgtatactt tgtattttgg tattaaattc tatgctgaag
     1381 atccatgtaa gctcaaagaa gagataacca gatatcagtt tttcttacag gtgaagcaag
     1441 atgcccttca gggccgtctg ccttgtcctg tcaatattgc cgctcagctg ggagcctatg
     1501 ccatccaggc cgaactggga gaccacgacc catgtaagca cactgcgggg tacgtgtcgg
     1561 agtaccggtt tgttcctgat cagaaggaag aactggaaga atctatagaa aggattcaca
     1621 agactctaat gggtcaggct ccttccgaag ctgagctgaa ttacttgagg actgcgaaat
     1681 ccctggagat gtacggcgtt gacctccatc ctgtctatgg agaaaataag tccgagtatt
     1741 tcttaggatt gactccagtg ggtgttgtcg tctataagaa taaaaagcaa gtggggaagt
     1801 atttctggcc tcggattacc aaggtgcact tcaaggaaac ccagtttgaa ctcagagtct
     1861 tgggaaaaga ctgtaatgag acctcgttct tttttgaagc tcggagcaaa actgcttgca
     1921 aacacctctg gaaatgcagt gtggagcacc atacattttt caggatgcca gaaacagagt
     1981 caaattcact gtcaagaaaa ctcagcaagt ttgggtccat aagttataaa caccgataca
     2041 gtggcaggac agctttgcaa atgagccgag atctttccat ccaacttccc cggcccaacc
     2101 agaacgtggt gagaagtcga agcaagactt accccaagag ggtagcacag acgcagcccg
     2161 ctggatccaa cagcatcaat cggatgactg caaacttgga aaacggggag aatgaaggaa
     2221 ccaccaagat cattgcgccc tcaccagtga aaagttttaa gaaagcaaag aatgaaaaca
     2281 gtcctgaccc ccaaagaagc aaatctcatg caccatggga agaaaacgga ccccagagtg
     2341 gactctacaa ctcccccagt gaccgcacta agtcaccaaa gtttccctgt acccggcagc
     2401 gcaacctctc ctgtggcagc gacaatgact cctcgcagcc aatgaggcga aggaaggctc
     2461 accacagtgg ggaagactcg gatctaaagc aacggaggag gtcacgctca cgctgtaaca
     2521 cgagcagtgg tagtgagtca gaaaattcta acagagaaca ccggaagaag agaaacagaa
     2581 tacgacagga gaatgacatg gttgattcag cgcctcagtg ggaagccgtg ttaaggagac
     2641 agaaggagaa aaaccaagtg gatcctaaca accggagatc caggcacaga tctcgctcga
     2701 gaagtcctga tatccaagca aaagaagaac tgtggaagca tatccagaag gagcttgtgg
     2761 acccatccgg gttgtcagag gagcagttga aagagatccc atacactaaa gtggagactc
     2821 agggtgaccc tgtccgcatc aggcattcgc attccccaag gagttaccgg cagtaccgca
     2881 gatcccagtg ctcagacgga gagcgatccg tcctctcgga agtgaactca aagacagatc
     2941 ttgtaccacc acttccagtc acccgttcct cagatgctca ggggtctgga ggctctacag
     3001 ttcatcagag aagaaacggg tctaaagaca gcctgattga agaaaaatct cagctttcta
     3061 caaccaacct ggctggaaaa catacagcaa aaacaataaa aaccatccag gctgctcggc
     3121 tcaagacaga cgtcactggg tgaaggggtg tagggaaacg tgtgtcactg gtacttttca
     3181 aactgtgaat tagataatta cccacgtatc ttggactcgt gtccttagca caagaaaatt
     3241 ggcatctttt aaggatttat gtacagcatt cttgtgctgt gggcctttgg aaggacaacc
     3301 ttatgaactc actggatacc accatctctt tcctgaaatt ctgaccatcc aactgtgttt
     3361 ctcacctctc caccacagcc aagaccagag gcttcagatg agcccctgga ctcccagctg
     3421 ccatcagact gtagtgactt ttattcccac aactgtttgt aatattgtat tttgtgacat
     3481 ttaagtccca atggttattt acaaataatg taaaaagctg ttaagtgttg atttgaattt
     3541 aa
//
LOCUS       NM_001437476            3541 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 6, mRNA.
ACCESSION   NM_001437476 XM_063277308
VERSION     NM_001437476.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3541)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3541)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3541)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3541)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3541)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3541)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3541)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3541)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277308.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2455797.1,
                                           SRR26360172.2669888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000018.1  48404539-48404670
            133-235             JAXUCZ010000018.1  48472546-48472648
            236-308             JAXUCZ010000018.1  48485845-48485917
            309-1177            JAXUCZ010000018.1  48504584-48505452
            1178-1357           JAXUCZ010000018.1  48507187-48507366
            1358-1471           JAXUCZ010000018.1  48514668-48514781
            1472-1597           JAXUCZ010000018.1  48523111-48523236
            1598-1767           JAXUCZ010000018.1  48526537-48526706
            1768-1860           JAXUCZ010000018.1  48532075-48532167
            1861-2914           JAXUCZ010000018.1  48532658-48533711
            2915-3541           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3541
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3541
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..132
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..235
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             179..2920
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 2 is encoded by transcript variant 6;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 2"
                     /protein_id="NP_001424405.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAA"
     misc_feature    <1139..1702
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1139..1702
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1220..1222,1226..1228,1238..1243,1250..1258,
                     1262..1267,1277..1279,1292..1294,1319..1321,1325..1327,
                     1331..1333,1448..1453,1460..1468,1472..1477,1487..1489,
                     1508..1510,1535..1537,1541..1543,1547..1549,1559..1564,
                     1571..1579,1583..1588,1598..1600,1607..1609,1634..1636)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1220..1222,1226..1228,1238..1243,1250..1258,
                     1262..1267,1277..1279,1292..1294,1319..1321,1325..1327,
                     1331..1333,1448..1453,1460..1468,1472..1477,1487..1489,
                     1508..1510,1535..1537,1541..1543,1547..1549,1559..1564,
                     1571..1579,1583..1588,1598..1600,1607..1609,1634..1636)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1220..1321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1220..1321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1325..1537
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1325..1537
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1541..1636
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1541..1636
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1709..1840
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1709..1840
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            236..308
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1177
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1357
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1471
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1597
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1767
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1860
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2914
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3541
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaacgctc ctcagacaag acagtttccc aggaccgtgt ccaccttcct tttctcattt
       61 cccggtttta tgctggaacc ttggaatggt ttggggacca atgaggtggc agcggttgat
      121 tcatggatcg tggatattat aaatattcga ccttactcaa aatgtacaaa gaagaataat
      181 ggaagcccct gaatatcttg atctggatga aatcgacttt agtgatgaca tttcttattc
      241 agtcacatct ctcaagacca tcccagcact gtgcagaaga tgtgactcac agaacgaaga
      301 cagaccagtt tctagctcta gctggaattg tggtgtctca actctcatta caaacccgca
      361 aaagcccact ggaatcgctg atgtatacag taagttccgc ccggtgaagc gagtttctcc
      421 actgaaacat cagccagaga ctctggagag caatgaaagt gacgaccaga agaacaatac
      481 agtggaatac cagaaagggg gggagactga ccagggcccc cagcctgagg agctcagccc
      541 tgaagatgga gtcggaggct tgccaggcaa gggctcagag cccagccagg cactgggtga
      601 gctggagcac tatgacctcg acatggatga gattctggat gtgccttaca ttaaatccag
      661 tcaacagctg gccccgctca ccaaggtgac ttcagaaaaa aggattttgg gtttatgcac
      721 aactgtcaat ggcctctctg ccaaaacctg ccctattgta agcgctgaga cctccacacc
      781 caacatggct ccattgtgtg ttctttctcc tgtgaaaagc cctcacttac ggaaagtacc
      841 cagtgtcctc cgggaccagc acaagctccc tgcggaagaa tcggagaact cacccgctcc
      901 tggtaaatgc ggccctgcat ttgaatcaga aaaccacagt aaggacttct taaacaaggt
      961 ctttagtgat ccccatagtc ggaaagctga gaagtctggg ccagactgca agctcaggcc
     1021 cttccgcctg cagacctcgg cagcaggagc caaaccagag gagcaggtca acggcgtgag
     1081 ctgggccagt gcccaaggcg cagaagaaag gactgagtac ctgcagaaag taagaagcat
     1141 actgaacatt gtgaacgaag ggcagatatc gctcttgcca cacctagctg cagataatct
     1201 ggacaaaatt cacgacgaga acggaaacaa tctgttacac gttgctgcat caaagggcca
     1261 tgcggaatgt ctgcagcacc tcacgtcgct gatgggcgaa gactgtctga atgaacggaa
     1321 cgcagagcaa ctgactccag cgggcctggc catcaagaat ggtcagctgg agtgtgtacg
     1381 ctggatggtg agtgagacgg aagccattgc ggaactgagt tgttccaagg atttcccaag
     1441 cctaattcat tacgcaggct gctatgggca ggaaaagatt cttctgtggc ttcttcagtt
     1501 catgcaagaa caaggcatct cattggatga agtagatcag gaaggcaaca gtgctgttca
     1561 tgtcgcttca caacatggct accttggatg catacagacc ctggtggagt atggagcaaa
     1621 tgttacgatg cagaaccacg ctggggaaaa gccctcccag agtgccgagc ggcacggcca
     1681 caccctatgt tcccggtacc tcgtggtggt agagacctgt atgtcactgg cctcacaagt
     1741 ggtaaagttg accaagcagc taaaggagca gacagtggag cgcgtcacac tgcagagtca
     1801 actccaacaa cttctggaag cccagaaatc agagggcaag tccctcccat cttcacccag
     1861 ttcaccctcc tcaccagctt ctagaaagtc ccagtggaaa attctagatg cagatgacga
     1921 gtctacaggc aaaagcaaac tgggaaccca ggagggaata caagtccttg gaaacttatc
     1981 cagcagggct aggaccaaag gaaaagacga agactctgat aaaatcctac gtcagttatt
     2041 ggggaaagaa atatcagaga atgtctgcac ccaggaaaag ctgtcattgg aattccagga
     2101 tgctcaggta tcctctagga attcgaaaaa aatacctcta gagaagaggg aactgaagct
     2161 agctagactg cggcagctga tgcagagatc tttgagtgaa tctgacacgg attcaaacaa
     2221 ctctgaggac cccaaaaata ctcctgtgaa aagagtggac agacctagac cacagcccat
     2281 tgtggaaagt gtggagaata tggacagtgc agaaagctta cacctgatga taaagaaaca
     2341 ctctgtggca tcaggacgca ggtttccttt tggtatgaag gcctccaaat ccctggatgg
     2401 gcacagccca tctcccactt cagagagcag tgaaccagat ttggactccc attgcccgag
     2461 cctgggaatg actcctccaa cccaaccttc tacagaagcc actcagtgca gtcctgacag
     2521 tgccactgcc cagaaagttg ctacaagccc caagagtgcc ctcaagtctc catcatccaa
     2581 gcgccggaca tcccaaaact caaaactgag agtgaccttt gaggagcctg ttgtgcaaat
     2641 ggagcaaact agccttgaac taaatggaga aaaagacaaa gagaggggca gggcccccca
     2701 gaggactagt gagtcaggag aacaaatgaa aaggcctttt ggaaccttcc gatccatcat
     2761 ggagagttta agtggtaatc agaacaacaa taataactac cagccagcca gccagctgaa
     2821 gacctgcaca ctacccttga cgtcacttgg aaggaagaca gcagatgcca agggaaaccc
     2881 tgtgagccct gctagcaaag gaaagaataa ggcagcttaa tgacatcaaa agaaacacga
     2941 agaaaactta caacgtaaag cacattgctg aaccagagcc aaaggaactc ttcttataaa
     3001 ttactcttag tatgagtctc acacatgccc tctggccacc attgggagtt aatggactgt
     3061 ggcaatcaga ccatgagaac aacacctcac cagcgagcag aatatctgga tgccttaaat
     3121 ttataatatg agacttgtta taagatacat tttggaccat atctgtacat agaacttgtt
     3181 tgatttcttt tttaatatgc tgtttgaaaa catgatcggg caatgtatgc attgacacat
     3241 tggacatttg attgagtcga ccttcttgaa gcacatccac cagcacctga cacgactagt
     3301 gtttttgtga attgcatgag gatttgctga tgttgattag atgttcacct tctttgtaac
     3361 aagggcagct gtggctcagc tcagtgaggc caggtcactg gttttatttt ctgtccagtg
     3421 tgtttttctg tcatttctac ttttttaata aagaaaatta aacatttgta acagcagact
     3481 ctgggcgtgg ggggcagggc atctactttc taataaatct gtgaagctct gatttctaaa
     3541 a
//
LOCUS       NM_001437454            1720 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 12, mRNA.
ACCESSION   NM_001437454 XM_063284143
VERSION     NM_001437454.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063284143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3073929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  104550886-104551024
            140-362             JAXUCZ010000001.1  104564592-104564814
            363-458             JAXUCZ010000001.1  104570948-104571043
            459-542             JAXUCZ010000001.1  104571207-104571290
            543-623             JAXUCZ010000001.1  104572252-104572332
            624-910             JAXUCZ010000001.1  104572931-104573217
            911-1105            JAXUCZ010000001.1  104574234-104574428
            1106-1279           JAXUCZ010000001.1  104574810-104574983
            1280-1415           JAXUCZ010000001.1  104576616-104576751
            1416-1540           JAXUCZ010000001.1  104577708-104577832
            1541-1720           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1720
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..139
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="upstream in-frame stop codon"
     CDS             60..1697
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 12 is encoded by transcript variant 12;
                     STK22 substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     12"
                     /protein_id="NP_001424383.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MDHQLRARREGCKSLTEAELQEKKTNGVEPRMSHEPMHWCLNLK
                     RSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLS
                     GVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQL
                     KNCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLE
                     AGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKV
                     SSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSAR
                     GLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVL
                     NLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKK
                     ILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPEEKVATLDYMHLKMC
                     SLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ"
     misc_feature    135..1694
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    135..1694
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    393..>713
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    393..>713
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     exon            140..362
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..458
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..623
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..910
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1105
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1279
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1415
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1540
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1720
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttcgat gacacactct ggaaccgccc cctaaacggc tgaaaccaac gctaattgga
       61 tggaccatca gctccgcgcc aggagggagg gatgtaagag tctgacggag gcggaacttc
      121 aggaaaagaa gaccaatggg gtggagcccc ggatgtccca cgagccgatg cactggtgcc
      181 tgaacctcaa gcggtcctca gcctgcacca acgtgtcctt gctcaacctg gctgccatgg
      241 agcccgactc ctccggtaca gactcgacca cagaggacag tggtccactg gcactgccag
      301 ggccacctgc ttcccctaca acaccctggg ctccagagga ccctgacatc acagaactac
      361 tgagtggggt caacagtgga ttggtacgtg ccaaagactc catcaccagc ttgaaggaaa
      421 agaccacgcg ggttaatcag catgttcaga cactgcagag cgagtgctct gtgctgagtg
      481 agaatctgga aagaaggcgg caggaggcag aagagttgga ggggtactgc agtcaattga
      541 agaactgccg caaggtgacc cgttcagtgg aagacgctga aatcaaaacc aatgtcctga
      601 agcagaactc tgccttgttg gaggagaagc taagatacct ccagcagcaa ctgcaggatg
      661 agacgccccg gagacaggag gccgagttgc aggagctgga gcaaaaacta gaggctggcc
      721 tctcccggca tggcctaggc cctactactc ccattcaggg ctgctccggt cctcctggta
      781 gcccggagga acccccgcgg ccgcgaggcc tgccctccaa tggctggggc atggcaatcc
      841 gcgcagggga gggaccctcg ctgagcgagc aggagttgca gaaggtctcc agcggcctag
      901 aggagctgag gagggaggtg tcctcgctgg cagctcggtg gcatcaggag gagggggcgg
      961 tgcaggaggc cctaaggttg ctgggaggcc tgggcggccg tctggatggc tttctgggcc
     1021 aatgggagcg ggcgcagcgg gaacaagcac agtccgcacg gggtttgcag gagctgcgag
     1081 gacgagcaga tgagctgtgc actatggtgg agaggtcagc agtgtctgtc gcttcactga
     1141 ggagcgaact ggaggcactg ggcccagtaa aaccgattct ggaggagctg ggacggcaac
     1201 ttcaaaactc ccgaagggga cctgaccatg tcttgaactt ggatcgtcct gcccaaggtc
     1261 cctgtcctcg atgtgccagc caggggcagc agttatccac ggagtcccta cagcagctgc
     1321 tggaacgtgc gctgacccca ctggtggacg aagtgaagca gaagggtctg gctcctgcct
     1381 gccccagttg ccagaggcta cacaagaaga ttctggagct ggagcgccag gccttggcca
     1441 aacacgtcag ggcagaggcc ctgagctcca cccttcggct ggcccaagac gaagccgttc
     1501 gggccaagaa cctactgctg acggacaaga tgaagccgga ggagaaggtg gccactttgg
     1561 actatatgca tttgaagatg tgttccctcc acgaccaact cagccacctg ccacttgagg
     1621 ggtccacagg ggcaatgggg ggaggaagca ctggaggggc tccccctaaa cgtgggggtc
     1681 caggctctga acaataaatg gcctctcatg ctggcatgaa
//
LOCUS       NM_001437530            3221 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 5, mRNA.
ACCESSION   NM_001437530 XM_063277539
VERSION     NM_001437530.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.56164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663595, SAMN13663597
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000018.1  30382855-30382961
            108-196             JAXUCZ010000018.1  30384474-30384562
            197-346             JAXUCZ010000018.1  30385379-30385528
            347-516             JAXUCZ010000018.1  30385958-30386127
            517-678             JAXUCZ010000018.1  30386679-30386840
            679-830             JAXUCZ010000018.1  30387819-30387970
            831-1373            JAXUCZ010000018.1  30394747-30395289
            1374-1602           JAXUCZ010000018.1  30396391-30396619
            1603-1775           JAXUCZ010000018.1  30399772-30399944
            1776-1906           JAXUCZ010000018.1  30401686-30401816
            1907-3221           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3221
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..107
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            108..196
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            197..346
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            347..516
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    465..467
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            517..678
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1964
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 5;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 1"
                     /protein_id="NP_001424459.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTA
                     QASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCF
                     NSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCS
                     SVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAIC
                     SSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKA
                     LEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKH
                     FTDPDSPCFNRLFHAVDVNGDIWEDEIED"
     misc_feature    549..929
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    549..929
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    1176..1352
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1176..1352
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1437..1607
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1437..1607
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1704..1907
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1704..1907
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            679..830
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1373
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1602
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1775
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1906
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..3221
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggtgcc cggtgactgc aggcctggct ggctagcgtg ttgcgagggc cccagtcaag
       61 ggcatactgc ggaactttcg ggcccggctc agctaagcgg ccggaaggtt ttctggctgt
      121 cctagaactt gctctgtaga ccaagctgga actcagagat ctgcctgcct ctaccacctg
      181 ggtactggga ttaaaggatg ttcctcacat tccgtaaccc acctatggat cacacttctg
      241 taaaactaaa cttcaattta gaggtcactc tcccactgag ctacattccc tcagtcatgg
      301 aggtctggct gtaaaccctg agtacctctt tcaagcttat gtgtatatgg cagaatttct
      361 gtagtatatt ggatgcaaat cccacatctt ggtttcttat ccagcttcag tctagcttca
      421 ctggctagaa aataaatggg atttgcacaa attccaagcc acagtgaaat aacgcttgca
      481 gcattgatat ccttttctcc tcgttgttac taacagaaaa ttcaatgtcg gcagaagacc
      541 tggaagccca ggaggatgaa ctactggccc tggcaagtat ttatgatgga gatgagttta
      601 gaaaagcaga gtctgtccaa ggaggggaaa ccaggatcta tttggatctg ccacagaatt
      661 tcaagatatt cgtgagcggc aattcaaatg agtgtctcca gaatagtggc tttgaataca
      721 ccatttgctt tctgccacca cttgtgctga actttgaact gccaccagat tatccatcct
      781 cctccccacc ttcattcaca cttagtggca aatggctgtc accaactcag ctctctgctc
      841 tctgcaagca cctggacaac ctgtgggaag aacaccgagg ccgtgtggtg ctgtttgcct
      901 ggatgcagtt tcttaaggag gagaccctta cctacctgaa tattgtctct ccttttgagc
      961 tcaagatggg gtctcagaaa aaggttcaga gaaggacaac agctcaggcc tcttccaaca
     1021 cagagcttgc tttgggagga gctgctgctg ctgctgctgc gtcagatgta gaccaagaag
     1081 acagtgtgga tgagagagct gtacaggatg tagaatcatt gtcaagtctg atccaggaaa
     1141 tcttggactt caatcaagat cgacagatga agtgcttcaa tagtaaactg ttcttgtgca
     1201 gtatctgttt ctgtgagaag ctggggagtg attgtatgta cttcttggag tgcagacatg
     1261 tatattgcaa agcctgtctg aaggattact ttgaaatcca gatcaaagat ggtcaagtta
     1321 aatgcctcaa ctgtccagaa ccacagtgtt cttcggtggc tactcctggt caggtcaaag
     1381 agctggtaga agcagactta tttgctcgct atgaccgcct cctcctccag tctactttgg
     1441 atctaatggc agatgtggtg tattgtcccc gtccatgctg ccagctccct gtgatgcaag
     1501 agcctggtgg caccatggct atctgctcca gctgcaattt tgccttctgc accttatgca
     1561 gactgaccta tcacggggtt tctccatgta aggtaacggc agagaaatta atagacttac
     1621 ggaatgaata cctacaagca gatgaagcta ctaaaaggtt cttggaacag aggtatggca
     1681 agagggtgat tcagaaggcc ctggaggaga tggagagtaa agactggctg gagaagaact
     1741 ccaagagctg cccctgctgt ggaacgccca tacagaaatt agacggctgc aacaagatga
     1801 cctgtactgg ctgtatgcag tatttctgct gggtttgcat gggctctctc tcaagagcaa
     1861 acccttacaa acatttcact gatcctgatt ctccatgctt taacaggttg ttccatgccg
     1921 tggatgtcaa tggagacatt tgggaagatg agattgagga ctagttcatt cctgctcgca
     1981 atgtagaaat ggaatggttt gccctgacct tctgtcaagt acacaaagag ccctcgcagg
     2041 atatttaggg taccatctat tcactcttca gtgtagaagg aagaacaggg tttatatttt
     2101 cctttggttc tactgattaa ggcacgtaca tttccatgta acataatctg ataaaattat
     2161 atgccaaagg atcagaaatg aaaactatag attaaatatt ataatatgcc caaactgtga
     2221 atagttaaaa agtaaatatt tattttctcc cccaagcttt aggttaggga gagggtcaag
     2281 agttaagctt ttagaccatg tccaagaagc ccctgcagct ggggacagtc acagccccag
     2341 ccacactgtc ctgggagcct gatccattct ctgtacactg ctcatttcca ttcgtgcttt
     2401 ggagagagcc tctgctctgt aactgaccaa atgtccagtg ttgttctgtt gtactgcttg
     2461 ccagaataga aatctataat aaattaaaaa atatttttag tattataatc cctgtgggtc
     2521 acttgatatt tatgaatagt gtattgaatc ccctggttta gagccaaatg tagaatttag
     2581 gattctggct cagaattcct ctagattcag agtcagagct gtctgtgctc ccttttgttc
     2641 tcagctttct ccctttgcct cccaccttct gttggcaagt acagttttaa tgttgattac
     2701 agcagtgtgt gtctttattt cctctgctag aatagaaaag agcccaatat attcctcatg
     2761 aatgctctct gaacctgtga acagcatcat ggttctaccc caccttctga acactcggga
     2821 attgggcttc ctcccctccc ctcccctcgt agacagcagt gtttggagtg ataatagtag
     2881 cttgatagct agattcctaa ccctggcttt tattggcttt ttgaaaaact gtcttcctcc
     2941 tgattcccta agtggcttgg tgtagtcact tggtggatgt tttggaaagg acagtaactc
     3001 acctgtagct tgtgaacttg tgttttctac tgtgacattg aaaattaagg attgcttaac
     3061 tgtcagctca aactgttgct ggattgtcaa tgaggatgct taatcttaac aataaagtaa
     3121 tttaaaatca tcccgtaatt ggagtaggca tggtgtctgt tgcttctgtc accaaagcac
     3181 tgactgaatt aaaactgact gtgtttctgt ttgttctgtt a
//
LOCUS       NM_001437518            2533 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 like 4A
            (Epb41l4a), transcript variant 5, mRNA.
ACCESSION   NM_001437518 XM_063277377
VERSION     NM_001437518.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2533)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277377.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.73201.1,
                                           SRR26360176.1479250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000018.1  25829231-25829396   c
            167-271             JAXUCZ010000018.1  25802641-25802745   c
            272-323             JAXUCZ010000018.1  25773271-25773322   c
            324-402             JAXUCZ010000018.1  25768091-25768169   c
            403-500             JAXUCZ010000018.1  25762381-25762478   c
            501-621             JAXUCZ010000018.1  25761136-25761256   c
            622-709             JAXUCZ010000018.1  25759154-25759241   c
            710-798             JAXUCZ010000018.1  25756917-25757005   c
            799-862             JAXUCZ010000018.1  25756320-25756383   c
            863-954             JAXUCZ010000018.1  25743152-25743243   c
            955-1032            JAXUCZ010000018.1  25741649-25741726   c
            1033-1154           JAXUCZ010000018.1  25736039-25736160   c
            1155-1245           JAXUCZ010000018.1  25715494-25715584   c
            1246-1329           JAXUCZ010000018.1  25711524-25711607   c
            1330-1443           JAXUCZ010000018.1  25710913-25711026   c
            1444-1491           JAXUCZ010000018.1  25708322-25708369   c
            1492-1569           JAXUCZ010000018.1  25707400-25707477   c
            1570-1689           JAXUCZ010000018.1  25694243-25694362   c
            1690-1737           JAXUCZ010000018.1  25686822-25686869   c
            1738-1806           JAXUCZ010000018.1  25685951-25686019   c
            1807-1917           JAXUCZ010000018.1  25681986-25682096   c
            1918-1999           JAXUCZ010000018.1  25681789-25681870   c
            2000-2533           JAXUCZ010000018.1  25680164-25680697   c
FEATURES             Location/Qualifiers
     source          1..2533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2533
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="erythrocyte membrane protein band 4.1 like 4A"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
     exon            1..166
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="upstream in-frame stop codon"
     exon            167..271
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            272..323
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            324..402
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            403..500
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            501..621
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..2134
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="isoform 3 is encoded by transcript variant 5;
                     erythrocyte protein band 4.1-like 4a; band 4.1-like
                     protein 4A"
                     /codon_start=1
                     /product="band 4.1-like protein 4A isoform 3"
                     /protein_id="NP_001424447.1"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
                     /translation="MGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPV
                     GVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWK
                     CSVEHHTFFRMPETESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLSIQLPRPNQNV
                     VRSRSKTYPKRVAQTQPAGSNSINRMTANLENGENEGTTKIIAPSPVKSFKKAKNENS
                     PDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPCTRQRNLSCGSDNDSSQPMRRRK
                     AHHSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRIRQENDMVDSAPQWEAV
                     LRRQKEKNQVDPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGLSEEQLKEIPY
                     TKVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVPPLPVTRSSDA
                     QGSGGSTVHQRRNGSKDSLIEEKSQLSTTNLAGKHTAKTIKTIQAARLKTDVTG"
     misc_feature    <623..700
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    <623..700
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    686..955
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    686..955
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    order(710..712,761..763,767..769,785..787)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(710..712,761..763,767..769,785..787)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(797..799,812..823,920..922,932..934,941..946)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(797..799,812..823,920..922,932..934,941..946)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    920..955
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    920..955
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    998..1132
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     misc_feature    998..1132
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     exon            622..709
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            710..798
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            799..862
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            863..954
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1032
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1154
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1245
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1329
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1443
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1491
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1569
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1689
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1737
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1806
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1917
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1999
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2533
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgctgtca aatcccagca gatggcggtg gccaaaagag taaggctggg gaggaagtgg
       61 cagtggggga agggcgtttt cttttgttca ctgctgatag aagtcgtccc tctgatctca
      121 agaagttgga agaaaccaga agagcctttc cagggtggga acacagaagt caaccaaagg
      181 ttccgttgtc cttgaccatg ttttccgtca cgtaaacctc gtggagatag attattttgg
      241 tctgcgatac tgcgacagaa gccatcagac atattggctg gatcccgcaa aaactcttgc
      301 agaacacaag gaactaatca acactggacc tccgtatact ttgtattttg gtattaaatt
      361 ctatgctgaa gatccatgta agctcaaaga agagataacc agatatcagt ttttcttaca
      421 ggtgaagcaa gatgcccttc agggccgtct gccttgtcct gtcaatattg ccgctcagct
      481 gggagcctat gccatccagg ccgaactggg agaccacgac ccatgtaagc acactgcggg
      541 gtacgtgtcg gagtaccggt ttgttcctga tcagaaggaa gaactggaag aatctataga
      601 aaggattcac aagactctaa tgggtcaggc tccttccgaa gctgagctga attacttgag
      661 gactgcgaaa tccctggaga tgtacggcgt tgacctccat cctgtctatg gagaaaataa
      721 gtccgagtat ttcttaggat tgactccagt gggtgttgtc gtctataaga ataaaaagca
      781 agtggggaag tatttctggc ctcggattac caaggtgcac ttcaaggaaa cccagtttga
      841 actcagagtc ttgggaaaag actgtaatga gacctcgttc ttttttgaag ctcggagcaa
      901 aactgcttgc aaacacctct ggaaatgcag tgtggagcac catacatttt tcaggatgcc
      961 agaaacagag tcaaattcac tgtcaagaaa actcagcaag tttgggtcca taagttataa
     1021 acaccgatac agtggcagga cagctttgca aatgagccga gatctttcca tccaacttcc
     1081 ccggcccaac cagaacgtgg tgagaagtcg aagcaagact taccccaaga gggtagcaca
     1141 gacgcagccc gctggatcca acagcatcaa tcggatgact gcaaacttgg aaaacgggga
     1201 gaatgaagga accaccaaga tcattgcgcc ctcaccagtg aaaagtttta agaaagcaaa
     1261 gaatgaaaac agtcctgacc cccaaagaag caaatctcat gcaccatggg aagaaaacgg
     1321 accccagagt ggactctaca actcccccag tgaccgcact aagtcaccaa agtttccctg
     1381 tacccggcag cgcaacctct cctgtggcag cgacaatgac tcctcgcagc caatgaggcg
     1441 aaggaaggct caccacagtg gggaagactc ggatctaaag caacggagga ggtcacgctc
     1501 acgctgtaac acgagcagtg gtagtgagtc agaaaattct aacagagaac accggaagaa
     1561 gagaaacaga atacgacagg agaatgacat ggttgattca gcgcctcagt gggaagccgt
     1621 gttaaggaga cagaaggaga aaaaccaagt ggatcctaac aaccggagat ccaggcacag
     1681 atctcgctcg agaagtcctg atatccaagc aaaagaagaa ctgtggaagc atatccagaa
     1741 ggagcttgtg gacccatccg ggttgtcaga ggagcagttg aaagagatcc catacactaa
     1801 agtggagact cagggtgacc ctgtccgcat caggcattcg cattccccaa ggagttaccg
     1861 gcagtaccgc agatcccagt gctcagacgg agagcgatcc gtcctctcgg aagtgaactc
     1921 aaagacagat cttgtaccac cacttccagt cacccgttcc tcagatgctc aggggtctgg
     1981 aggctctaca gttcatcaga gaagaaacgg gtctaaagac agcctgattg aagaaaaatc
     2041 tcagctttct acaaccaacc tggctggaaa acatacagca aaaacaataa aaaccatcca
     2101 ggctgctcgg ctcaagacag acgtcactgg gtgaaggggt gtagggaaac gtgtgtcact
     2161 ggtacttttc aaactgtgaa ttagataatt acccacgtat cttggactcg tgtccttagc
     2221 acaagaaaat tggcatcttt taaggattta tgtacagcat tcttgtgctg tgggcctttg
     2281 gaaggacaac cttatgaact cactggatac caccatctct ttcctgaaat tctgaccatc
     2341 caactgtgtt tctcacctct ccaccacagc caagaccaga ggcttcagat gagcccctgg
     2401 actcccagct gccatcagac tgtagtgact tttattccca caactgtttg taatattgta
     2461 ttttgtgaca tttaagtccc aatggttatt tacaaataat gtaaaaagct gttaagtgtt
     2521 gatttgaatt taa
//
LOCUS       NM_001107379            3801 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 1, mRNA.
ACCESSION   NM_001107379 XM_001055030 XM_225768
VERSION     NM_001107379.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3801)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3801)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3801)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3801)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3801)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3801)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3801)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001107379.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               JAXUCZ010000018.1  48405478-48405798
            322-424             JAXUCZ010000018.1  48472546-48472648
            425-497             JAXUCZ010000018.1  48485845-48485917
            498-1366            JAXUCZ010000018.1  48504584-48505452
            1367-1546           JAXUCZ010000018.1  48507187-48507366
            1547-1660           JAXUCZ010000018.1  48514668-48514781
            1661-1786           JAXUCZ010000018.1  48523111-48523236
            1787-1956           JAXUCZ010000018.1  48526537-48526706
            1957-2049           JAXUCZ010000018.1  48532075-48532167
            2050-3103           JAXUCZ010000018.1  48532658-48533711
            3104-3174           JAXUCZ010000018.1  48534878-48534948
            3175-3801           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3801
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..424
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    329..331
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             368..3259
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 1"
                     /protein_id="NP_001100849.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAM
                     YSSCIHLPSNALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     misc_feature    <1328..1891
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1328..1891
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1409..1411,1415..1417,1427..1432,1439..1447,
                     1451..1456,1466..1468,1481..1483,1508..1510,1514..1516,
                     1520..1522,1637..1642,1649..1657,1661..1666,1676..1678,
                     1697..1699,1724..1726,1730..1732,1736..1738,1748..1753,
                     1760..1768,1772..1777,1787..1789,1796..1798,1823..1825)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1409..1411,1415..1417,1427..1432,1439..1447,
                     1451..1456,1466..1468,1481..1483,1508..1510,1514..1516,
                     1520..1522,1637..1642,1649..1657,1661..1666,1676..1678,
                     1697..1699,1724..1726,1730..1732,1736..1738,1748..1753,
                     1760..1768,1772..1777,1787..1789,1796..1798,1823..1825)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1409..1510
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1409..1510
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1514..1726
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1514..1726
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1730..1825
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1730..1825
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1898..2029
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1898..2029
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            425..497
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1366
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1546
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1660
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1786
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1956
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2049
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..3103
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3174
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3801
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggcgttc tgcttgctgc tacctcggat cgtcccggag gcggggatgg gctgtgccga
       61 ggctcctaag agctcccagg gaggggcaaa ggcttggtga tagctacact agtaaccaga
      121 acaataacaa acgtgaaggg gatgccgggt ggtgtcgcta cccgaaggga gcccctggcc
      181 catcagcccc gcggcgccta ggctgccccg tccagcttca gctcctcctc ccggcgctgt
      241 ccggcgtccc gggattatcc acgtcctggg gaaggcttct ttcctgaccc tctcagtggc
      301 ggtgactttc ctttgcaggt ggatattata aatattcgac cttactcaaa atgtacaaag
      361 aagaataatg gaagcccctg aatatcttga tctggatgaa atcgacttta gtgatgacat
      421 ttcttattca gtcacatctc tcaagaccat cccagcactg tgcagaagat gtgactcaca
      481 gaacgaagac agaccagttt ctagctctag ctggaattgt ggtgtctcaa ctctcattac
      541 aaacccgcaa aagcccactg gaatcgctga tgtatacagt aagttccgcc cggtgaagcg
      601 agtttctcca ctgaaacatc agccagagac tctggagagc aatgaaagtg acgaccagaa
      661 gaacaataca gtggaatacc agaaaggggg ggagactgac cagggccccc agcctgagga
      721 gctcagccct gaagatggag tcggaggctt gccaggcaag ggctcagagc ccagccaggc
      781 actgggtgag ctggagcact atgacctcga catggatgag attctggatg tgccttacat
      841 taaatccagt caacagctgg ccccgctcac caaggtgact tcagaaaaaa ggattttggg
      901 tttatgcaca actgtcaatg gcctctctgc caaaacctgc cctattgtaa gcgctgagac
      961 ctccacaccc aacatggctc cattgtgtgt tctttctcct gtgaaaagcc ctcacttacg
     1021 gaaagtaccc agtgtcctcc gggaccagca caagctccct gcggaagaat cggagaactc
     1081 acccgctcct ggtaaatgcg gccctgcatt tgaatcagaa aaccacagta aggacttctt
     1141 aaacaaggtc tttagtgatc cccatagtcg gaaagctgag aagtctgggc cagactgcaa
     1201 gctcaggccc ttccgcctgc agacctcggc agcaggagcc aaaccagagg agcaggtcaa
     1261 cggcgtgagc tgggccagtg cccaaggcgc agaagaaagg actgagtacc tgcagaaagt
     1321 aagaagcata ctgaacattg tgaacgaagg gcagatatcg ctcttgccac acctagctgc
     1381 agataatctg gacaaaattc acgacgagaa cggaaacaat ctgttacacg ttgctgcatc
     1441 aaagggccat gcggaatgtc tgcagcacct cacgtcgctg atgggcgaag actgtctgaa
     1501 tgaacggaac gcagagcaac tgactccagc gggcctggcc atcaagaatg gtcagctgga
     1561 gtgtgtacgc tggatggtga gtgagacgga agccattgcg gaactgagtt gttccaagga
     1621 tttcccaagc ctaattcatt acgcaggctg ctatgggcag gaaaagattc ttctgtggct
     1681 tcttcagttc atgcaagaac aaggcatctc attggatgaa gtagatcagg aaggcaacag
     1741 tgctgttcat gtcgcttcac aacatggcta ccttggatgc atacagaccc tggtggagta
     1801 tggagcaaat gttacgatgc agaaccacgc tggggaaaag ccctcccaga gtgccgagcg
     1861 gcacggccac accctatgtt cccggtacct cgtggtggta gagacctgta tgtcactggc
     1921 ctcacaagtg gtaaagttga ccaagcagct aaaggagcag acagtggagc gcgtcacact
     1981 gcagagtcaa ctccaacaac ttctggaagc ccagaaatca gagggcaagt ccctcccatc
     2041 ttcacccagt tcaccctcct caccagcttc tagaaagtcc cagtggaaaa ttctagatgc
     2101 agatgacgag tctacaggca aaagcaaact gggaacccag gagggaatac aagtccttgg
     2161 aaacttatcc agcagggcta ggaccaaagg aaaagacgaa gactctgata aaatcctacg
     2221 tcagttattg gggaaagaaa tatcagagaa tgtctgcacc caggaaaagc tgtcattgga
     2281 attccaggat gctcaggtat cctctaggaa ttcgaaaaaa atacctctag agaagaggga
     2341 actgaagcta gctagactgc ggcagctgat gcagagatct ttgagtgaat ctgacacgga
     2401 ttcaaacaac tctgaggacc ccaaaaatac tcctgtgaaa agagtggaca gacctagacc
     2461 acagcccatt gtggaaagtg tggagaatat ggacagtgca gaaagcttac acctgatgat
     2521 aaagaaacac tctgtggcat caggacgcag gtttcctttt ggtatgaagg cctccaaatc
     2581 cctggatggg cacagcccat ctcccacttc agagagcagt gaaccagatt tggactccca
     2641 ttgcccgagc ctgggaatga ctcctccaac ccaaccttct acagaagcca ctcagtgcag
     2701 tcctgacagt gccactgccc agaaagttgc tacaagcccc aagagtgccc tcaagtctcc
     2761 atcatccaag cgccggacat cccaaaactc aaaactgaga gtgacctttg aggagcctgt
     2821 tgtgcaaatg gagcaaacta gccttgaact aaatggagaa aaagacaaag agaggggcag
     2881 ggccccccag aggactagtg agtcaggaga acaaatgaaa aggccttttg gaaccttccg
     2941 atccatcatg gagagtttaa gtggtaatca gaacaacaat aataactacc agccagccag
     3001 ccagctgaag acctgcacac tacccttgac gtcacttgga aggaagacag cagatgccaa
     3061 gggaaaccct gtgagccctg ctagcaaagg aaagaataag gcagcgatgt acagcagctg
     3121 cattcatctt ccctctaatg cgctggtcga agagcatctg cgtgattatg cacggcttaa
     3181 tgacatcaaa agaaacacga agaaaactta caacgtaaag cacattgctg aaccagagcc
     3241 aaaggaactc ttcttataaa ttactcttag tatgagtctc acacatgccc tctggccacc
     3301 attgggagtt aatggactgt ggcaatcaga ccatgagaac aacacctcac cagcgagcag
     3361 aatatctgga tgccttaaat ttataatatg agacttgtta taagatacat tttggaccat
     3421 atctgtacat agaacttgtt tgatttcttt tttaatatgc tgtttgaaaa catgatcggg
     3481 caatgtatgc attgacacat tggacatttg attgagtcga ccttcttgaa gcacatccac
     3541 cagcacctga cacgactagt gtttttgtga attgcatgag gatttgctga tgttgattag
     3601 atgttcacct tctttgtaac aagggcagct gtggctcagc tcagtgaggc caggtcactg
     3661 gttttatttt ctgtccagtg tgtttttctg tcatttctac ttttttaata aagaaaatta
     3721 aacatttgta acagcagact ctgggcgtgg ggggcagggc atctactttc taataaatct
     3781 gtgaagctct gatttctaaa a
//
LOCUS       NR_199356               4192 bp    RNA     linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 7, non-coding RNA.
ACCESSION   NR_199356 XM_039096701
VERSION     NR_199356.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096701.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000018.1  41088223-41088526   c
            305-539             JAXUCZ010000018.1  41084042-41084276   c
            540-865             JAXUCZ010000018.1  41075830-41076155   c
            866-1012            JAXUCZ010000018.1  41073397-41073543   c
            1013-1108           JAXUCZ010000018.1  41065895-41065990   c
            1109-1362           JAXUCZ010000018.1  41061600-41061853   c
            1363-1487           JAXUCZ010000018.1  41061277-41061401   c
            1488-1778           JAXUCZ010000018.1  41059874-41060164   c
            1779-1843           JAXUCZ010000018.1  41059121-41059185   c
            1844-2023           JAXUCZ010000018.1  41049925-41050104   c
            2024-4192           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4192
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     misc_RNA        1..4192
                     /gene="Trim36"
                     /product="tripartite motif-containing 36, transcript
                     variant 7"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..304
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            305..539
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..865
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1012
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1108
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1362
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1487
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1778
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1843
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2023
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..4192
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtccgcg cgagccgccg ccgcagccgg cagcggggcg tcattcgccg ctccctgggc
       61 cctcgcaggg agcaaccgca ctctccgcgc ccgtgctttc gcctgcgccg gccagtccct
      121 cgccgcgtgg cccgctggcc ggatctggcg gaccagcttg ccctccggtc tgacccgagg
      181 ctcccgaatc gccgcgggga ctcgcccaca cgaccctgct ggggcccgct gcgcctgtaa
      241 agactcggtg gttgatgtca cccggcggag ggctgcgatg gagggggatg cttcagactc
      301 tcaggtgact atcaagaata tcgaaaagga gcttatttgc ccagcatgca aggagctgtt
      361 tacacacccg ctgatccttc cctgccagca cagcgtctgt cataaatgtg tgaaagaact
      421 cttactgtct cttgatgact cattcaacga tgtggcgtca gacagctcta atcagagcag
      481 ccctcggctc cggctcacct cccccagcat ggataaaatc gacaagatta acagaccagg
      541 ctggaagcgt aattcactga cccccagacc aaccatgttt ccttgtcctg gctgcgagca
      601 tgatgtggat cttggagagc gaggagtcag tggtctgttt cgaaatttca ctttggaaac
      661 gattgtcgag aggtaccggc aggctgctag ggcagccaca gccattatgt gtgacctttg
      721 taaaccacca ccccaggaat ctacaaagag ctgcatggat tgtagtgcaa gctactgcaa
      781 cgaatgcttc aaaatttatc atccctgggg cacggtaaaa gcccagcatg agtatgtggg
      841 ccccaccact aatttcagac ccaagatttt aatgtgccca gaacatgaga cagagagaat
      901 aaacatgtac tgtgaactgt gcaggagacc ggtttgccac ctctgtaagt tgggtgggaa
      961 tcattccaat caccgggtaa ccaccatgag cagtgcctac aaaacattaa aggagaaact
     1021 ttcaaaagac attgatttcc ttattggtaa ggaaagccag gtgaagagtc aaatttctga
     1081 actaaacttg ttaatgaaag aaacagagtg caatggagag agggcgaagg aagaagcgct
     1141 ggcacatttt gagaagctct ttgaaatcct ggaagacagg aagtcgtctg ttctgaaagc
     1201 catagatgcc tctaagaaac taagactaga taaatttcac actcaaatgg aagagtacca
     1261 aggccttcta gagaataacg ggcttgtggg atatgctcag gaagtgctga aggagacgga
     1321 tcagtcttgc tttgtgcaga cagcaaagca gctccatctc agaatacaga aagctacaga
     1381 atccctgaag agctttagac ctgcagccca ggcttctttt gaagactatg ttgttaacat
     1441 ttcgaaacaa acagaggtgc ttggagaatt gtcctttttc tctagtggca tagacattcc
     1501 tgagatcaac gaggaacaga gtaaagtgta taataatgcc ctgatagact ggcaccatcc
     1561 agaaaaggac aaagccgaca gctatgttct cgaataccgc aagattaata gagacgaaga
     1621 aatgatatcc tggaatgaga tagaagttca tggcacaagt aaagttgtct ccaatcttga
     1681 aagcaacagt ccctatgcgt tccgagtgag agcttacagg ggttctatct gcagtccctg
     1741 cagtcgagaa ctggttctgc atactcctcc agctccaggt tatgctgaca ttacttatta
     1801 tttattaggt tgaagaactt tactggatag gaaggacata cagttttcag tttcctgttt
     1861 gatgaaaagt gtggctacaa tactgagcat ctcttgctga acctgaagag agaccgggta
     1921 gaaagcagag ctggatttaa tgtcctcctc gctgcggaac gcatccaagt gggccattac
     1981 acaagcttag actacatcat cggggatgtc ggaatcacga aagatatgag caagacagtg
     2041 ggcatgacag cggaagtgag gacgcctatt ttgattcttc acaaccgttt acattagtta
     2101 ctataggcat gaagaaattt tttataccca agtcacctac ttcttctaat gaacccgaaa
     2161 acagagttct ccccatgcca acaagtatag ggattttcct tgactgtgat aaaggcaaag
     2221 tgagcttcta tgatatggac cacatgaaat gcctatatga gcgccaggtg gactgttcac
     2281 acacaatgta ccccgctttt gcgttaatgg gcagtggcgg gatccagctt gaggaaacca
     2341 tcaccgcgaa gtatctggaa tatgaagagg atgtgtagct tggacacccc acaggacgag
     2401 gatcagaact gtgaacaaag ccatgccgtg gtgttagagt cttcgtaact aattacatat
     2461 catttacgtc tctgtcacca cacctgtttg tactgtgtga ttctttgttt tgttttgttc
     2521 tgctttgaca cacacagtct cagtgtgtag tccaggccag cttcaaactc tgttctgtta
     2581 tagcctcctt aggggctggg attataggca ggcaccacca tacccagcta gtgtatgatt
     2641 cacaactttt ttcatgtcat aatggtctta ccttttacaa atggtgggag tagagacttg
     2701 tcttaactgg tccaggatag ataactctac aatggaagtc cttctctttg gggacaagga
     2761 ctctaattga tgtaagtcag ctgatggtgg tattattcct gtccctttgt ttgggggttg
     2821 cagtgggata caaagtattt acaaagttct ttgtgcttgt tttcttcttt ccttttcatt
     2881 gtgtatcatg ttcatgtcca aagagaagat atttttaaat gtttatcgat agaaattagt
     2941 actaagccat gtgtcttgca tttgatgtta ataggaaaat aaatttacag ataggtaaaa
     3001 tgatgaaggc cataaaatgg tagtatattt aagtagaaaa ttatgtattt taaagtgtgt
     3061 aactactgag tgtatattgc ctggcaaacg aatactgctt tttccctcta tagaccacag
     3121 actgtattgg taagaatatc tctaagagtg tctttgctgt agtgcccatt gtcctgtaca
     3181 tgtagcaagc atcgtttcat ataagaaaca cagggttctt gaacccatgc gactttccac
     3241 tacaatagaa ttctttttca ggaaatttta ttttcaaatt ttcttatttt agaaaatact
     3301 catttatagc aaagaattat ttttcagaaa tactagggaa gatggactga tagtgaacac
     3361 ctatcttttt gtgtcttgtg aactttatga ttttggtaca tatgttatac atcagggttt
     3421 tctggctttt gtttacagat ttgagaagtt tgctgtccat tttcagcgtt gttgaatgcc
     3481 agacatgtta catgttacta ctgtccactt ggatggcact gtttgtgggc tcattgtgtg
     3541 gtcataagca tttgtagtgt gaatcagtaa aatacaaaat tccttagaca taatagctaa
     3601 acatcacaag gatgtgtcta gtcagttttt acaccttttc tacactagat gttaatttct
     3661 gcaaggttac tttccaatta tttgaattgc ctttttaaaa gttaaaatgt ccagacacta
     3721 agacttacat gtgttcagca ctgatcatgc aatggaatgg tagcattttg gtagaataac
     3781 caaagctgtt tatttgattg attcttttta atggaagcct gttgggctaa tcacactgca
     3841 tctgacccag cactgactgg tacgcatccc tacgcttgtg tagaaatatc tggaggattt
     3901 gtgtttagtg attgcccttc ctctcccact tatatctagc actttatgac ataggaaaca
     3961 gagagaatgt gcagtgttac ctggggtcat tgtgcaataa tgctgctaaa gtcgccgcac
     4021 gtgtgggtta gtgtgacact caatattcat gtaagcacat gtcctgtaga cattttaaaa
     4081 tataaagctt taactggagt cagagaagcg agctgttcga acactgtatc actgtataga
     4141 aattgcttag tggaattcca cttttttaaa ataaaaaaat aaataaaggg aa
//
LOCUS       NR_199267                967 bp    RNA     linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 12, non-coding RNA.
ACCESSION   NR_199267
VERSION     NR_199267.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 967)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.643950.1,
                                           SRR26360176.2357162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840131, SAMN17050748
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-290             JAXUCZ010000011.1  44823304-44823443
            291-476             JAXUCZ010000011.1  44827804-44827989
            477-967             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..967
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     misc_RNA        1..967
                     /gene="Mrps6"
                     /product="mitochondrial ribosomal protein S6, transcript
                     variant 12"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    106..414
                     /gene="Mrps6"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001437294.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            151..290
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            291..476
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            477..967
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg ccagagaccg ctgctgcttt aaaacgtaca
      181 atagaatccc tgatggaccg aggagccata gtgaggaact tggaaaacct gggtgagcgt
      241 gcactcccat acaggatctc cagtcacagc cagcagcaca gccgaggagg gcagccagtg
      301 gcgcggctgt gtctgcgggc ctggggtggt ctctctcagc gctctggggt ctgcggccct
      361 caactgagca tggatctcgg gttttgtgga agttgtagaa acctggactt ctagcaccaa
      421 accttggcca aaggactgtt ctaaaacctg tgcatctgtt gcttcagcct tctgaggtat
      481 ttcttggtgg atttttatgc cccaacaaat gctgtggaaa gcatgctgga acacttggca
      541 cgagacactg atgtggttag accaaatatt gtgaaacacc ctctgaccca ggaagtaaaa
      601 gagtgtgacg gcatagtccc agtccctctt gaagaaaaac tgtattcaac aaagagaagg
      661 aagaagtgag aagattcacc agatgtggct atgttcaatt ctaagtgcac catgggtgct
      721 gataggtttg tctaggatgc tttagcccgt gaccattttg ctgcagatgg ggactgctgg
      781 ccgagacctg ctctgtcacc cctgctgata tttcaccctc actgtgtgat tgtcagggtg
      841 cggtggggct ggtgttcaca gtcccactgc agagtttcga agaacaaaat gtttgtcatt
      901 cacactcggt tgtcttgtaa acctgtgtgg aacacagagc agagtaataa acatggtttt
      961 atcaaca
//
LOCUS       NR_199357               4310 bp    RNA     linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 8, non-coding RNA.
ACCESSION   NR_199357 XM_039096701
VERSION     NR_199357.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4310)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4310)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4310)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4310)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77210.1,
                                           SRR26360181.1158893.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000018.1  41088223-41088526   c
            305-539             JAXUCZ010000018.1  41084042-41084276   c
            540-865             JAXUCZ010000018.1  41075830-41076155   c
            866-1012            JAXUCZ010000018.1  41073397-41073543   c
            1013-1108           JAXUCZ010000018.1  41065895-41065990   c
            1109-1362           JAXUCZ010000018.1  41061600-41061853   c
            1363-1487           JAXUCZ010000018.1  41061277-41061401   c
            1488-1778           JAXUCZ010000018.1  41059874-41060164   c
            1779-1843           JAXUCZ010000018.1  41059121-41059185   c
            1844-2141           JAXUCZ010000018.1  41049807-41050104   c
            2142-4310           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4310
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4310
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     misc_RNA        1..4310
                     /gene="Trim36"
                     /product="tripartite motif-containing 36, transcript
                     variant 8"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..304
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            305..539
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..865
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1012
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1108
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1362
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1487
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1778
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1843
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2141
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..4310
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtccgcg cgagccgccg ccgcagccgg cagcggggcg tcattcgccg ctccctgggc
       61 cctcgcaggg agcaaccgca ctctccgcgc ccgtgctttc gcctgcgccg gccagtccct
      121 cgccgcgtgg cccgctggcc ggatctggcg gaccagcttg ccctccggtc tgacccgagg
      181 ctcccgaatc gccgcgggga ctcgcccaca cgaccctgct ggggcccgct gcgcctgtaa
      241 agactcggtg gttgatgtca cccggcggag ggctgcgatg gagggggatg cttcagactc
      301 tcaggtgact atcaagaata tcgaaaagga gcttatttgc ccagcatgca aggagctgtt
      361 tacacacccg ctgatccttc cctgccagca cagcgtctgt cataaatgtg tgaaagaact
      421 cttactgtct cttgatgact cattcaacga tgtggcgtca gacagctcta atcagagcag
      481 ccctcggctc cggctcacct cccccagcat ggataaaatc gacaagatta acagaccagg
      541 ctggaagcgt aattcactga cccccagacc aaccatgttt ccttgtcctg gctgcgagca
      601 tgatgtggat cttggagagc gaggagtcag tggtctgttt cgaaatttca ctttggaaac
      661 gattgtcgag aggtaccggc aggctgctag ggcagccaca gccattatgt gtgacctttg
      721 taaaccacca ccccaggaat ctacaaagag ctgcatggat tgtagtgcaa gctactgcaa
      781 cgaatgcttc aaaatttatc atccctgggg cacggtaaaa gcccagcatg agtatgtggg
      841 ccccaccact aatttcagac ccaagatttt aatgtgccca gaacatgaga cagagagaat
      901 aaacatgtac tgtgaactgt gcaggagacc ggtttgccac ctctgtaagt tgggtgggaa
      961 tcattccaat caccgggtaa ccaccatgag cagtgcctac aaaacattaa aggagaaact
     1021 ttcaaaagac attgatttcc ttattggtaa ggaaagccag gtgaagagtc aaatttctga
     1081 actaaacttg ttaatgaaag aaacagagtg caatggagag agggcgaagg aagaagcgct
     1141 ggcacatttt gagaagctct ttgaaatcct ggaagacagg aagtcgtctg ttctgaaagc
     1201 catagatgcc tctaagaaac taagactaga taaatttcac actcaaatgg aagagtacca
     1261 aggccttcta gagaataacg ggcttgtggg atatgctcag gaagtgctga aggagacgga
     1321 tcagtcttgc tttgtgcaga cagcaaagca gctccatctc agaatacaga aagctacaga
     1381 atccctgaag agctttagac ctgcagccca ggcttctttt gaagactatg ttgttaacat
     1441 ttcgaaacaa acagaggtgc ttggagaatt gtcctttttc tctagtggca tagacattcc
     1501 tgagatcaac gaggaacaga gtaaagtgta taataatgcc ctgatagact ggcaccatcc
     1561 agaaaaggac aaagccgaca gctatgttct cgaataccgc aagattaata gagacgaaga
     1621 aatgatatcc tggaatgaga tagaagttca tggcacaagt aaagttgtct ccaatcttga
     1681 aagcaacagt ccctatgcgt tccgagtgag agcttacagg ggttctatct gcagtccctg
     1741 cagtcgagaa ctggttctgc atactcctcc agctccaggt tatgctgaca ttacttatta
     1801 tttattaggt tgaagaactt tactggatag gaaggacata cagttttcag tttcctgttt
     1861 gatgaaaagt gtggctacaa tactgagcat ctcttgctga acctgaagag agaccgggta
     1921 gaaagcagag ctggatttaa tgtcctcctc gctgcggaac gcatccaagt gggccattac
     1981 acaagcttag actacatcat cggggatgtc ggaatcacga aaggtaaaca cttctgggcc
     2041 tgccgtgtgg aaccgtattc atacctggtg aaagtgggag ttgcttccag tgacaaactg
     2101 caagagtggc tgcgctctcc ccgggacgca gctagtccaa gatatgagca agacagtggg
     2161 catgacagcg gaagtgagga cgcctatttt gattcttcac aaccgtttac attagttact
     2221 ataggcatga agaaattttt tatacccaag tcacctactt cttctaatga acccgaaaac
     2281 agagttctcc ccatgccaac aagtataggg attttccttg actgtgataa aggcaaagtg
     2341 agcttctatg atatggacca catgaaatgc ctatatgagc gccaggtgga ctgttcacac
     2401 acaatgtacc ccgcttttgc gttaatgggc agtggcggga tccagcttga ggaaaccatc
     2461 accgcgaagt atctggaata tgaagaggat gtgtagcttg gacaccccac aggacgagga
     2521 tcagaactgt gaacaaagcc atgccgtggt gttagagtct tcgtaactaa ttacatatca
     2581 tttacgtctc tgtcaccaca cctgtttgta ctgtgtgatt ctttgttttg ttttgttctg
     2641 ctttgacaca cacagtctca gtgtgtagtc caggccagct tcaaactctg ttctgttata
     2701 gcctccttag gggctgggat tataggcagg caccaccata cccagctagt gtatgattca
     2761 caactttttt catgtcataa tggtcttacc ttttacaaat ggtgggagta gagacttgtc
     2821 ttaactggtc caggatagat aactctacaa tggaagtcct tctctttggg gacaaggact
     2881 ctaattgatg taagtcagct gatggtggta ttattcctgt ccctttgttt gggggttgca
     2941 gtgggataca aagtatttac aaagttcttt gtgcttgttt tcttctttcc ttttcattgt
     3001 gtatcatgtt catgtccaaa gagaagatat ttttaaatgt ttatcgatag aaattagtac
     3061 taagccatgt gtcttgcatt tgatgttaat aggaaaataa atttacagat aggtaaaatg
     3121 atgaaggcca taaaatggta gtatatttaa gtagaaaatt atgtatttta aagtgtgtaa
     3181 ctactgagtg tatattgcct ggcaaacgaa tactgctttt tccctctata gaccacagac
     3241 tgtattggta agaatatctc taagagtgtc tttgctgtag tgcccattgt cctgtacatg
     3301 tagcaagcat cgtttcatat aagaaacaca gggttcttga acccatgcga ctttccacta
     3361 caatagaatt ctttttcagg aaattttatt ttcaaatttt cttattttag aaaatactca
     3421 tttatagcaa agaattattt ttcagaaata ctagggaaga tggactgata gtgaacacct
     3481 atctttttgt gtcttgtgaa ctttatgatt ttggtacata tgttatacat cagggttttc
     3541 tggcttttgt ttacagattt gagaagtttg ctgtccattt tcagcgttgt tgaatgccag
     3601 acatgttaca tgttactact gtccacttgg atggcactgt ttgtgggctc attgtgtggt
     3661 cataagcatt tgtagtgtga atcagtaaaa tacaaaattc cttagacata atagctaaac
     3721 atcacaagga tgtgtctagt cagtttttac accttttcta cactagatgt taatttctgc
     3781 aaggttactt tccaattatt tgaattgcct ttttaaaagt taaaatgtcc agacactaag
     3841 acttacatgt gttcagcact gatcatgcaa tggaatggta gcattttggt agaataacca
     3901 aagctgttta tttgattgat tctttttaat ggaagcctgt tgggctaatc acactgcatc
     3961 tgacccagca ctgactggta cgcatcccta cgcttgtgta gaaatatctg gaggatttgt
     4021 gtttagtgat tgcccttcct ctcccactta tatctagcac tttatgacat aggaaacaga
     4081 gagaatgtgc agtgttacct ggggtcattg tgcaataatg ctgctaaagt cgccgcacgt
     4141 gtgggttagt gtgacactca atattcatgt aagcacatgt cctgtagaca ttttaaaata
     4201 taaagcttta actggagtca gagaagcgag ctgttcgaac actgtatcac tgtatagaaa
     4261 ttgcttagtg gaattccact tttttaaaat aaaaaaataa ataaagggaa
//
LOCUS       NR_199358               2137 bp    RNA     linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Ras and Rab interactor-like (Rinl), transcript
            variant 5, non-coding RNA.
ACCESSION   NR_199358 XM_006228656
VERSION     NR_199358.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006228656.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  93204794-93204825
            33-167              JAXUCZ010000001.1  93206397-93206531
            168-327             JAXUCZ010000001.1  93206696-93206855
            328-430             JAXUCZ010000001.1  93209713-93209815
            431-503             JAXUCZ010000001.1  93211848-93211920
            504-568             JAXUCZ010000001.1  93212006-93212070
            569-715             JAXUCZ010000001.1  93212633-93212779
            716-1192            JAXUCZ010000001.1  93212866-93213342
            1193-1480           JAXUCZ010000001.1  93213660-93213947
            1481-1635           JAXUCZ010000001.1  93214087-93214241
            1636-1799           JAXUCZ010000001.1  93214371-93214534
            1800-2137           JAXUCZ010000001.1  93214620-93214957
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2137
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     misc_RNA        1..2137
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /product="Ras and Rab interactor-like, transcript variant
                     5"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     exon            1..32
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            33..167
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..1503
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001106241.2"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            168..327
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            328..430
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            431..503
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            504..568
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            569..715
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1192
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1480
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1635
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1799
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..2137
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct gctcaggctc ccctcggaac agttcttgcc ctagctggag cagccttgag
       61 tcttgtcttc ctccatgcca gaggccaaag catggctcac tggtgcctgg cagcatgagg
      121 ctagcccagc cggacatggt gtctgcagcc actactgaag aggccaggct gagttggcca
      181 ctagcagaag gagcagacaa gagcccactg agggtcctca gcacgacaga gtcacttctt
      241 cgactgcaga ggacacagag ggtgtggcag gtccccgagc tggacgctga gcatgccaag
      301 gcctttctca agccgtggcc actggggagc ttcctggtca tcgggcagga ccctgaccag
      361 gtcctgatgt tgaagacagg accttcgtca ggagatatca acacctacca aattcagaag
      421 tttcctggag gtgtgtccct ggaatcctcc aacctctgca tgccagactt tcctcatctc
      481 ctggcctttc tgtcagccag cagggacgtt ttgccaagga ctctgctctt gcccacacct
      541 actgtggggc ctggagataa gcactcagat cctcgtcgac ttggctgcat ccaggtggac
      601 acctcaggga gggtgctgtc tgtggtgaac cagctctacc tggagaccca tggaggctgg
      661 gaaacagaaa caccgcagca aacaaagcca gaaactggcc agaaacgcag tctagccccc
      721 aggatgccca ctccacaccg ggtctcctgg gtggaagagt ctctgaaacc ggaagctcac
      781 catactggac aggaagtgca tcatccagaa agacaagtgc attatcctgg accagaagct
      841 cactctcttg ggccagaagt acactttcct agtcctgttc tagaagagga ggaagaagtg
      901 aacaatgaca gctacaagga tgaagaggaa ggctgcgagg atatgctcac tgcccacatc
      961 cgtgctctgg ccagtgcccg gagcagttat gtagccaggc agtaccaatg ccttcgagca
     1021 cgactcatct cagattctgg aaatccctac agcccagggg acccagccac agagctgctt
     1081 caggatgtac gccagctcct cactgacctc caggattacc tggcaaaaga ccccgatgtc
     1141 agagctgtct ttgggaatag gggacctagc atccctcggg aagaagatct tggccccgct
     1201 gtggaggtgg ccctgtgtcg agcggttctg gagcccctga agcccgccct gtggaccaaa
     1261 ctccgaactc tcagagccca ggaactgcgg cgactgcgcc ggcgccaaat agccttgagg
     1321 gtaggagcag gacccgaggg acagagcccg gccttgcgga accgtatcca cgcacgcctc
     1381 gctcacctgc acgcagcgtg cgccccgcgc cgcaaggtgg cgctgttgtt ggcggtgtgc
     1441 agcgatgtct atgcaggcct ggctggcggc gagaataaag gacctgtcct ctggcttcct
     1501 tagagcccct gggggctgac gcctttttac ctgccctgac cgaggagctg atctggagtc
     1561 cacatattgg ggaaacacag ctggatgtgg agtttcttat ggagctcttg gatccagggg
     1621 agttgcgagg agaagctggg tattatctta ccacgtggtt tggggctctc taccacattg
     1681 ctcactacca gcctgatgct ggccgtgcac cccaggagct cagctctgag gcccgggcct
     1741 ccttgcgcca gtggcaccga agacggacac tgcaccagca agcccagccc acagccccgg
     1801 aaaaccagcc ctttgaggag ccatgggcaa taggggaccc atgatgattg gagtcctcaa
     1861 aaatcagtct ccagaacctt ttggcccact cctctgctaa gcaagattct ggaggcatct
     1921 gggtcagcac agtgggtggg gcagaaaaaa ggacgtggcg ttttgcactg gctgttccta
     1981 cttccttcct tcccctcctg gtctgtccac atgttacctc aatgaggctc tccccagcaa
     2041 acaaaaccaa cgcctaaaca atactacaac tacagccctc tcacctgaat ctctctgggg
     2101 caggtagaat aaaggcacag tccccaaaag gtatcta
//
LOCUS       NM_001114602            2583 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus protocadherin beta 5 (Pcdhb5), mRNA.
ACCESSION   NM_001114602 NM_001014781 XM_001064542 XM_226003
VERSION     NM_001114602.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Wu,Q.
  TITLE     Comparative genomics and diversifying selection of the clustered
            vertebrate protocadherin genes
  JOURNAL   Genetics 169 (4), 2179-2188 (2005)
   PUBMED   15744052
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jun 28, 2018 this sequence version replaced NM_001114602.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643298.73641.1,
                                        SRR26643294.57249.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2583              JAXUCZ010000018.1  29302466-29305048
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2583
                     /gene="Pcdhb5"
                     /note="protocadherin beta 5"
                     /db_xref="GeneID:291654"
                     /db_xref="RGD:1304665"
     exon            1..2583
                     /gene="Pcdhb5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    130..132
                     /gene="Pcdhb5"
                     /note="upstream in-frame stop codon"
     CDS             190..2583
                     /gene="Pcdhb5"
                     /codon_start=1
                     /product="protocadherin beta-4"
                     /protein_id="NP_001108074.2"
                     /db_xref="GeneID:291654"
                     /db_xref="RGD:1304665"
                     /translation="MEKLERNHANRQVIPFLFMLLWGQVLMVPTRYSVLEEAERGSFV
                     AHLAKDLGLGAGELAARSARVVSDFDNQQFMVDPDTGDLLLREKLDREELCGSVDPCV
                     MHFQVFLEKPVQFFQGELLIQDINDNSPEFPDKELLLKIPENSQPGTRFPLNLAQDLD
                     VGSNGLQEYRVSTNPHFHVLTRNNSEGKKYPELVQDRALDREEQAELSLTLMALDGRS
                     PPRSGTALVRILIMDINDNAPEFVNSPYEVQVPESCPPDSPILTVLAPDADAGNFGSV
                     SYGLFQASDEIQKTFSINEVTGEIRLKKELDFEKTESYRVEIEATDGGGLSGKGSVVI
                     EVLDVNDNAPELTISSLTSSVPENAPETVVAIIRIRDRDSGDNGKMICSISDHVPFTL
                     KPSYKNFYTLVTERALDRESRAEYNITISVSDQGTPRLTTQHTITVQVSDINDNAPAF
                     TQTSYTMFVHENNSPALHIGTISATDSDSGSNAHITYSLLPPYDPQLALDSLISINPD
                     NGQLFALRALDYEALQAFEFRVAATDGGSPALSSQALVRVMVLDDNDNAPFVLYPLQN
                     ASAPYTELLPRAAEPGYLITKVVAVDRDSGQNSWLSFQLLKSTEPGLFSVWAHNGEVR
                     TTRLLSERDVPKHRLLLVVKDNGEPPRSASITLQVVLVDGFSQPYLPLPEVARDSAKD
                     GADLLTLYLVIALASVSSLFLLSVLLFVGVRLCRRARAASLGDCTVPEGHFPGHLVDV
                     SRAGTLSQSYQYEVCLTGDSGAGEFKFLKSMVPNLMVQDPGREIAENLHCRDSFVFS"
     misc_feature    274..522
                     /gene="Pcdhb5"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    274..522
                     /gene="Pcdhb5"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    604..900
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    604..900
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(616..621,787..789,793..795,886..888,892..897)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(616..621,787..789,793..795,886..888,892..897)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    922..1215
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    922..1215
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(943..948,1108..1110,1114..1116,1201..1203,
                     1207..1212)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(943..948,1108..1110,1114..1116,1201..1203,
                     1207..1212)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1249..1527
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1249..1527
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1258..1263,1414..1416,1420..1422,1513..1515,
                     1519..1524)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1258..1263,1414..1416,1420..1422,1513..1515,
                     1519..1524)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1549..1857
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1549..1857
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1570..1575,1744..1746,1750..1752,1843..1845,
                     1849..1854)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1570..1575,1744..1746,1750..1752,1843..1845,
                     1849..1854)
                     /gene="Pcdhb5"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1897..2178
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1897..2178
                     /gene="Pcdhb5"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    2248..2496
                     /gene="Pcdhb5"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
     misc_feature    2248..2496
                     /gene="Pcdhb5"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
ORIGIN      
        1 tttgtgttgc aagacagaat caaaaaaaca cagggacagg aaacatctga aggaataccg
       61 gaccctgaat gggtttgggc cggggtatac tacatgaaca aagattcctc cagccaagaa
      121 aatagaattt agcattcaag ctattcagag gctgctgaag aactggatgt aagcactcgt
      181 gtttccacca tggagaagct ggagagaaat catgcaaaca ggcaagtgat tcctttcctt
      241 tttatgctgc tttggggtca ggttctcatg gtgcctactc ggtactctgt cttggaggaa
      301 gctgaaagag gctcctttgt agcccatctg gccaaggatc tggggctggg agctggggag
      361 ctggctgcca ggtctgcacg ggtggtgtct gactttgaca accagcaatt catggtggat
      421 ccggacactg gagatttgct tctgagggag aaactagaca gggaggaatt gtgtggctct
      481 gtggatccct gtgtgatgca tttccaggtg ttcctagaaa aaccagtgca gttttttcaa
      541 ggagaattat tgatccagga tataaatgac aactcgccag aattcccaga taaagaattg
      601 ctcttgaaaa taccggaaaa cagccagcca ggcacgcggt ttccattgaa tttagcccag
      661 gatttggatg tgggcagcaa tggacttcaa gagtacagag tcagcaccaa ccctcatttt
      721 catgtcctca ctcgaaataa tagtgaaggc aagaaatacc cagagttggt acaagacaga
      781 gccctggaca gagaggagca ggcagaattg agcttaacgc tcatggctct ggatggcagg
      841 tctccaccta ggtcaggaac agctctggtt cgaatcctga tcatggatat caatgacaat
      901 gctcctgagt ttgtgaacag cccctacgag gtgcaggtcc cagagagctg tcccccagac
      961 tccccaattc tgactgtctt agcaccggat gcagatgctg gcaactttgg gagtgtttcc
     1021 tatggcttgt tccaagcatc agatgaaatc cagaaaactt tctcaataaa tgaagtcact
     1081 ggagaaatac ggctgaagaa ggaattggat tttgaaaaaa ctgaatcata ccgtgtagag
     1141 attgaggcca cagatggagg agggctttct gggaaaggat ctgtggtgat agaggtgttg
     1201 gatgtgaacg acaatgcccc agagctgacc atatcttcac tgaccagctc agtcccagaa
     1261 aatgctccgg aaactgtggt tgctattatc cgaatacgag atagagattc tggagacaat
     1321 ggaaaaatga tttgctctat ttcagatcat gtgccattca ctttaaaacc ctcttacaag
     1381 aacttttaca ctctggtgac agagagggca ctggacagag agagcagagc tgagtacaac
     1441 atcaccatct cagtctcgga ccagggcaca cccaggctca caacccagca caccataaca
     1501 gtgcaggtgt ctgacatcaa cgacaacgcc cctgccttca cccaaacctc ctacaccatg
     1561 tttgtccacg agaacaacag ccccgccctg cacataggca ccatcagtgc cacagactca
     1621 gactcaggct ccaatgccca catcacctac tcactgctac cgccctatga tccacagctg
     1681 gccctcgact cgctcatctc catcaaccca gacaatgggc agctgttcgc gctcagggcg
     1741 ctggactatg aggccctgca ggccttcgag ttccgagtgg ccgccacaga tggaggttca
     1801 cccgcgctaa gcagccaggc tctggtgcgc gtgatggtgc tggatgacaa tgacaatgca
     1861 cccttcgtgc tctacccgct gcagaacgcc tctgcaccct acacagagct gcttcccagg
     1921 gcagcagagc ccggatacct gatcaccaag gtggtggcag tggaccgcga ctctggccag
     1981 aactcctggc tgtcgtttca gctgctcaag tccacggagc ccgggttgtt cagtgtgtgg
     2041 gcgcacaatg gcgaggtgcg taccaccagg ctgctgagtg agcgcgatgt gcccaaacac
     2101 aggctgctgc tggtggtcaa ggacaatggt gagcctccac gctctgccag catcacactg
     2161 caggtggtgc ttgtggatgg cttttcacag ccttatctgc cactgcctga ggtagctcgt
     2221 gactctgcaa aggatggtgc ggacttgctc acgctctatc tggtcatcgc cttggcctct
     2281 gtgtcttctc tatttttgtt gtctgtgctg ctgttcgtgg gggtgaggct gtgcaggaga
     2341 gcaagggcag cctctctggg tgactgcact gtgcctgagg gccactttcc tggccacctg
     2401 gtagatgtca gtcgtgcagg gaccctgtcc cagagctacc agtatgaggt gtgtctgaca
     2461 ggagactctg gggctggtga gttcaaattc cttaaatcca tggtccccaa cctaatggtt
     2521 caggaccctg ggagagaaat tgcggaaaat cttcattgca gggatagctt tgtattcagc
     2581 taa
//
LOCUS       NM_001135710            2233 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus SEC14-like lipid binding 5 (Sec14l5), mRNA.
ACCESSION   NM_001135710 XM_001079060
VERSION     NM_001135710.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 28, 2018 this sequence version replaced NM_001135710.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.25308.1,
                                           SRR26643284.12795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000010.1  10942286-10942386   c
            102-205             JAXUCZ010000010.1  10941597-10941700   c
            206-355             JAXUCZ010000010.1  10922645-10922794   c
            356-487             JAXUCZ010000010.1  10921827-10921958   c
            488-616             JAXUCZ010000010.1  10920930-10921058   c
            617-809             JAXUCZ010000010.1  10919912-10920104   c
            810-922             JAXUCZ010000010.1  10917011-10917123   c
            923-1112            JAXUCZ010000010.1  10915723-10915912   c
            1113-1201           JAXUCZ010000010.1  10912576-10912664   c
            1202-1272           JAXUCZ010000010.1  10912427-10912497   c
            1273-1444           JAXUCZ010000010.1  10911774-10911945   c
            1445-1579           JAXUCZ010000010.1  10909970-10910104   c
            1580-1714           JAXUCZ010000010.1  10908330-10908464   c
            1715-1942           JAXUCZ010000010.1  10907775-10908002   c
            1943-2121           JAXUCZ010000010.1  10905898-10906076   c
            2122-2233           JAXUCZ010000010.1  10904345-10904456   c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2233
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="SEC14-like lipid binding 5"
                     /db_xref="GeneID:287060"
                     /db_xref="RGD:1564638"
     exon            1..101
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            102..205
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2233
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="SEC14-like 5 protein"
                     /codon_start=1
                     /product="SEC14-like protein 5"
                     /protein_id="NP_001129182.2"
                     /db_xref="GeneID:287060"
                     /db_xref="RGD:1564638"
                     /translation="MVQKYQSPVRVYKYPFELVMAAYEKRFPTCPLIPVFLGSEVLSE
                     CRSADGAVHTVERSCRLRVDAPRLLRKIAGVEHVVFIQRNVLNWRERTLLIDAHNETF
                     ASRVTVKEHCRYTVHPENEDWTCFEQSASLDVRSFFGFESTLEKIAMKQYTANVKRGK
                     EVIEHYLSELISQGASHIPRWTPAPVREADVRSQLVCPCPSSLETDGPSDAPAPASEM
                     ATADGDKLDADYIERCLGHLSPMQESCLVQLRRWLQETHKGKIPKDEHILRFLRARDF
                     HLDKARDMLCQSLSWRKQHQVDLLLQTWRPPAPLQEFYAGGWHYQDIDGRPLYILRLG
                     QMDTKGLMKAVGEEALLQHVLSVNEEGQKRCEGNTRQFGRPISSWTCLLDLEGLNMRH
                     LWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLVSPFINENTRRKFLIY
                     SGSNYQGPGGLVDYLDKDVIPDFLGGESVCNVPEGGMVPKSLYLTEEEQEQADQLRQW
                     SETYHSASVLRGSPHEVAMEIPEGESVITWDFDILRGDVVFSLYHAKQAPKLSPQEPG
                     VRASGQLIDKNWILGVDYSRVEAPLICREGQSIQGSHVTQWPGVYLLQWQIHSPPESV
                     ACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCASRFSQLSATTTS
                     SSSGQSHSGSMVSR"
     misc_feature    191..661
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="PRELI-like family; Region: PRELI; pfam04707"
                     /db_xref="CDD:398400"
     misc_feature    191..661
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="PRELI-like family; Region: PRELI; pfam04707"
                     /db_xref="CDD:398400"
     misc_feature    869..1006
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="CRAL/TRIO, N-terminal domain; Region: CRAL_TRIO_N;
                     smart01100"
                     /db_xref="CDD:215024"
     misc_feature    869..1006
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="CRAL/TRIO, N-terminal domain; Region: CRAL_TRIO_N;
                     smart01100"
                     /db_xref="CDD:215024"
     misc_feature    1082..1570
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="CRAL/TRIO domain; Region: CRAL_TRIO; pfam00650"
                     /db_xref="CDD:459890"
     misc_feature    1082..1570
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /note="CRAL/TRIO domain; Region: CRAL_TRIO; pfam00650"
                     /db_xref="CDD:459890"
     exon            206..355
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            356..487
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            488..616
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            617..809
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1112
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1201
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1272
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1444
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1579
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1714
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1942
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2121
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2233
                     /gene="Sec14l5"
                     /gene_synonym="RGD1564638"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgctctc cggacaaggc gctttctggg gatctggcga gctcagctcc caggtcaagc
       61 aggtgccaga gcactgcgct gtgtctccag cagttctgag gcttctgtgt tccctctgcc
      121 tgggtggttt ctgagtttga acatggtgca gaaataccag tctcctgtcc gggtatacaa
      181 gtatccattc gagctggtca tggcggccta cgagaagcgc ttccccacct gtccacttat
      241 cccagtcttt ctgggtagtg aagtcctgag cgagtgtcga agcgcagatg gggcagtgca
      301 caccgtagag cggagctgca ggctgcgagt ggatgcccca cggctgctgc ggaagatcgc
      361 tggtgtggag cacgtggtct tcattcagag aaatgtcctg aactggagag agagaacgct
      421 gcttatagat gctcacaatg agacgtttgc gagccgagtg acggtgaagg aacactgccg
      481 ctacacggtc catcccgaga atgaagactg gacttgcttt gaacagtccg cctctctgga
      541 tgtccgctct ttctttggct ttgagagcac cttggagaag atcgccatga agcagtacac
      601 tgccaatgtc aagaggggga aggaggtgat tgaacactat ctgagcgagc tcatttccca
      661 gggggcatcc cacattcccc gctggacacc agccccagtc cgggaggcgg atgtccgcag
      721 ccagcttgtg tgcccgtgcc ctagctccct ggagaccgat ggccccagtg atgccccagc
      781 ccctgcttct gagatggcta cggctgatgg ggacaagttg gatgcagact acattgagag
      841 gtgcctgggc catctcagtc ccatgcagga gagttgcctg gtccagcttc ggcgctggtt
      901 acaggagacc cacaaaggca agatccccaa agatgagcac atcctgcgct tcttgagggc
      961 tcgcgacttc cacctggaca aggcccggga tatgttgtgc cagtccttga gctggcggaa
     1021 gcagcaccag gtggatctcc ttctgcagac ctggcggccc cccgccccgc tgcaggagtt
     1081 ctatgctgga ggttggcact accaggatat agatggccgc cccctctaca tcctgcgtct
     1141 gggacagatg gacaccaaag gcctgatgaa ggcagtggga gaggaagctt tgctgcagca
     1201 tgttctttct gtcaacgagg aaggacagaa gagatgcgaa ggaaacacga gacaatttgg
     1261 ccgtcccatc agctcctgga cctgcttgct ggacctagag ggcctcaaca tgaggcatct
     1321 atggcgacct ggggtgaaag ccctgctgag gatgatcgag gtggtggagg acaattaccc
     1381 cgagactctg ggcaggttgc tcatcgtgcg tgcgccccgt gtcttcccgg tgctgtggac
     1441 gctggtcagc cccttcatca acgagaacac caggcggaag ttcctcatct acagtggcag
     1501 caattatcag ggccctggcg gcctagtgga ctatctggac aaggacgtga tccccgactt
     1561 cctgggagga gagagcgtgt gtaacgttcc agaaggaggg atggtcccca agtccctcta
     1621 tctgacagag gaggagcagg agcaggctga tcagctacgg cagtggagtg agacctacca
     1681 ttcagccagc gtgcttcgtg gaagccccca tgaggttgcc atggagatac cagaagggga
     1741 gtcagtcatc acctgggact ttgatatcct cagaggggat gtggtgttca gtctgtatca
     1801 tgcaaaacag gcacccaagc tcagtcccca ggagcctggg gttagagcca gtggacagct
     1861 gatcgacaag aactggatcc tgggggtgga ttatagccga gtagaggcac cccttatctg
     1921 ccgggaaggg cagagcattc agggttccca tgttactcag tggcctggcg tctacctgct
     1981 ccagtggcag attcacagtc cccccgagag tgtggcctgc agtctcccgg gtgtggatga
     2041 cgtcctgaca gctctgcaca gccctggccc caagtgcaag ctgctatact actgtgaagt
     2101 gctagcatct gaagacttca ggggctccat gtccagcctg gaatcctgtg ccagccgctt
     2161 ctctcagctc agcgccacca ccacctcctc ctcctctggc cagtcccaca gtggctcgat
     2221 ggtgtccaga tag
//
LOCUS       NM_001166760             825 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 99 (Vom1r99), mRNA.
ACCESSION   NM_001166760 XM_002726412 XM_002729399
VERSION     NM_001166760.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 825)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 825)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_002726412.1, XM_002729399.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               JAXUCZ010000004.1  123988112-123988936 c
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..825
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="vomeronasal 1 receptor 99"
                     /db_xref="GeneID:685880"
                     /db_xref="RGD:1589006"
     CDS             1..825
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="vomeronasal 1 receptor Vom1r99; vomeronasal 1
                     receptor pseudogene 113"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 99"
                     /protein_id="NP_001160232.1"
                     /db_xref="GeneID:685880"
                     /db_xref="RGD:1589006"
                     /translation="MSEILFVFPQPLFSYVMSTNSRLHTDSHIRDTFFTEIGIGISVN
                     NLPLLFHIFTLIRGQRSRLTDLPIDLLSLLNLLMLLMWLLATDIFISWRGWDDIICKF
                     LVYLYRSFRGLSLCTTCLLSVLQAIILSPRSSCLAKFKHMPTHQVSNAMLFLSVLYMF
                     ISSHLLLSITATPSLTTNDFIHVTQSCSILPLSYLMPSMFSILLAIRVVFLISLMVLS
                     TWYMLALLFRHRKQSRHLQGTSLSPKASPGQRVTHSILMHKRGTQIKSSGYLQLSI"
     misc_feature    79..>771
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="vomeronasal organ pheromone receptor type-1 family,
                     member of the seven-transmembrane G protein-coupled
                     receptor superfamily; Region: 7tm_V1R_pheromone; cd13949"
                     /db_xref="CDD:320087"
     misc_feature    79..>771
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="vomeronasal organ pheromone receptor type-1 family,
                     member of the seven-transmembrane G protein-coupled
                     receptor superfamily; Region: 7tm_V1R_pheromone; cd13949"
                     /db_xref="CDD:320087"
     misc_feature    82..159
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    82..159
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    193..258
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320087"
     misc_feature    193..258
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320087"
     misc_feature    301..369
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    301..369
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    445..495
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    445..495
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    598..669
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     misc_feature    598..669
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     exon            1..825
                     /gene="Vom1r99"
                     /gene_synonym="Vom1r-ps113"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtgaga ttctgttcgt ttttcctcag ccactgttct catatgtgat gagtacgaac
       61 agcagactcc acactgattc tcacataagg gatacctttt tcactgaaat tggcattgga
      121 atctcagtca acaacctccc acttctcttc cacatcttca cgttaattcg tgggcagagg
      181 tccagactca ctgacctgcc cattgatctc ttgtccctac tcaacttact tatgctactg
      241 atgtggctat tagccacaga catttttatt tcttggaggg gatgggatga catcatatgt
      301 aaattccttg tctacctgta cagaagtttt agaggtctct ctctttgtac cacctgcctg
      361 ttgagtgtcc tgcaggccat catcctcagt cccagaagct cctgtttagc aaagttcaaa
      421 catatgccta ctcatcaggt ctccaatgcc atgcttttcc tgagtgtcct ctacatgttt
      481 attagcagtc atctcttatt atccatcact gccaccccca gtttgaccac gaatgacttt
      541 attcatgtta ctcagtcctg ctctattcta cccttgagtt acctcatgcc aagcatgttt
      601 tctatactgc tggccatcag ggttgtcttt cttattagtc tcatggttct ctcaacatgg
      661 tacatgctgg ctctcttgtt taggcacagg aaacagtccc ggcatcttca gggtaccagc
      721 ctttccccaa aagcatcccc agggcaaagg gtcacccatt ccatcctgat gcataaaaga
      781 ggcacccaaa taaaatcatc tggttacctt caattgtcaa tttga
//
LOCUS       NM_001191797            4365 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Nik related kinase (Nrk), transcript variant 2,
            mRNA.
ACCESSION   NM_001191797 XM_236524
VERSION     NM_001191797.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4365)
  AUTHORS   Denda,K., Nakao-Wakabayashi,K., Okamoto,N., Kitamura,N., Ryu,J.Y.,
            Tagawa,Y.I., Ichisaka,T., Yamanaka,S. and Komada,M.
  TITLE     Nrk, an X-linked protein kinase in the germinal center kinase
            family, is required for placental development and fetoplacental
            induction of labor
  JOURNAL   J Biol Chem 286 (33), 28802-28810 (2011)
   PUBMED   21715335
REFERENCE   2  (bases 1 to 4365)
  AUTHORS   Nakano,K., Yamauchi,J., Nakagawa,K., Itoh,H. and Kitamura,N.
  TITLE     NESK, a member of the germinal center kinase family that activates
            the c-Jun N-terminal kinase pathway and is expressed during the
            late stages of embryogenesis
  JOURNAL   J Biol Chem 275 (27), 20533-20539 (2000)
   PUBMED   10801798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236524.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMN09345238
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000021.1  107159553-107159609
            58-123              JAXUCZ010000021.1  107165785-107165850
            124-180             JAXUCZ010000021.1  107200886-107200942
            181-252             JAXUCZ010000021.1  107202180-107202251
            253-378             JAXUCZ010000021.1  107205586-107205711
            379-489             JAXUCZ010000021.1  107207220-107207330
            490-580             JAXUCZ010000021.1  107209297-107209387
            581-715             JAXUCZ010000021.1  107211751-107211885
            716-794             JAXUCZ010000021.1  107216217-107216295
            795-970             JAXUCZ010000021.1  107216765-107216940
            971-1034            JAXUCZ010000021.1  107218615-107218678
            1035-2193           JAXUCZ010000021.1  107219102-107220260
            2194-2295           JAXUCZ010000021.1  107222619-107222720
            2296-2363           JAXUCZ010000021.1  107225695-107225762
            2364-2458           JAXUCZ010000021.1  107227237-107227331
            2459-2556           JAXUCZ010000021.1  107230028-107230125
            2557-2900           JAXUCZ010000021.1  107232790-107233133
            2901-3201           JAXUCZ010000021.1  107234312-107234612
            3202-3367           JAXUCZ010000021.1  107236311-107236476
            3368-3439           JAXUCZ010000021.1  107237051-107237122
            3440-3583           JAXUCZ010000021.1  107238848-107238991
            3584-3742           JAXUCZ010000021.1  107241619-107241777
            3743-3843           JAXUCZ010000021.1  107242959-107243059
            3844-3993           JAXUCZ010000021.1  107244905-107245054
            3994-4129           JAXUCZ010000021.1  107247824-107247959
            4130-4269           JAXUCZ010000021.1  107251037-107251176
            4270-4365           JAXUCZ010000021.1  107253022-107253117
FEATURES             Location/Qualifiers
     source          1..4365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..4365
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="Nik related kinase"
                     /db_xref="GeneID:315907"
                     /db_xref="RGD:1566163"
     CDS             1..4365
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nik-related protein kinase"
                     /codon_start=1
                     /product="nik-related protein kinase isoform 2"
                     /protein_id="NP_001178726.1"
                     /db_xref="GeneID:315907"
                     /db_xref="RGD:1566163"
                     /translation="MAGPGSWRDKEVTDLGHLPDPTGIFSLEKTIGLGTYGRIYLGLH
                     EKTGSFVAIKVMNARKTPLPEIGKRVRVNKYRKSVGWRYSDEEEDLRTELNLLRKYSF
                     HKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICRE
                     ILQGLAHLHAHQVIHRDIKGQNVLLTQDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYW
                     MAPEVIHCDEDPRRSYDYRVTLCNLQPLEALFVILREAAPTVKSSGWSRKFQNFMENC
                     MIKNFLFRPTSGNMLHHPFVHDIKNERRVVESLTKHLTGIIQKRERKGIPLAFEGEEA
                     VNEQYITRRFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDEEQPEDQELQQL
                     QEAARMFMPLHSQDKTLKPLQKQAQLPQHLHVAPQVLMPVQVEATVATPLAKKIRAPP
                     QLSKAAWGLTSPPSQDNKASSPEVQAPIPREQQAQNDALETEQPEDLDQVPEEFQGQD
                     RAAEEQRQGQAAEQEQRQNGVPEQHPEENREPEQAEVQEEAVEPPQAEVEEKDPEVIQ
                     VHARVFLPLQSQNHHVFLPLHLDTQLLIPVGEQNEEAPRAQAWDLEASRAAGAVQALV
                     EGLSRDLLRAPNAFTSKPLGPLQILLESLCTNGFYTEPEAVQKKKSRVSSLKKAIVKR
                     LTPKRFRAKALWRRQDFECSDVESSRRRRQRRWEEIFNQHEEQLREVENDRDDDDSSD
                     NDEVFHSIQAEVQIEPYAPNRTGNEVQERSAPMPCNRNRTHRVKFSPSVCEQALLEEA
                     QQPMDIRPRNSLNPRNFQAESESSSEEDSPVTRRKSQSSPPYSTIDQRLLIDIHVPDG
                     FKVGKISPPVYLTNEWVGCNPLSEVFWDDWVNPTPATRRHEEDGDYVELYDADANGDG
                     RASNYAYEENYASGHDDMNHQANGYRGHGNRHYSDGSFRNRGDSRGAAFNGPRASYCR
                     GGILKNAGNDGRDLRRGAFRAYGDNEASNYHGAASGASAAFGSQEGHEGHMGGRRGNR
                     YREVNGSSGENGACGFHRDGAGLDQQHVFPDFENEQEQSDAGTETSDSIALEITSFSL
                     DGEQNNDRAEPTLGFPLRRSSSRGSASDTDIMSDSYNKPIIHAYEREFSHEIFCGSLW
                     GVNLLLGTKSHLYLMDRSGKAEIIKLVKRRPFRQIQVVEQLNLLITISGRKNRLRVYH
                     LTWLRNKILNNDPESKKRQKAMLKREKACKSLDKLIGCEHFSILHHEETTYIAIALKS
                     SIHLYAWAPKSFNESTAIKVFPTHDLKPVTVDLAVGSEKTLKIFFSSANGYHIIDAES
                     EVMSDVTLPSNNVILLPDSLGVGVMLSFNDETAPEEANEQLLKKILDVWKDIPSSAAF
                     ECTQRITGWDQKAVEVRSLQATILENELKRRSIKKLRFLCSRGDKLFFASLLNNEHSL
                     VYYVSIAKLEALQRRYAV"
     misc_feature    40..888
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    40..888
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(91..102,109..111,115..117,154..156,160..162,
                     319..321,385..396,529..531,541..546,550..552,580..585)
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(91..102,109..111,115..117,154..156,160..162,
                     319..321,385..396,529..531,541..546,550..552,580..585)
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    <1372..1914
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="cell division protein FtsN; Region: PRK10927"
                     /db_xref="CDD:236797"
     misc_feature    <1372..1914
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="cell division protein FtsN; Region: PRK10927"
                     /db_xref="CDD:236797"
     misc_feature    3436..4260
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     misc_feature    3436..4260
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     exon            1..57
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            58..123
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            124..180
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            181..252
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            253..378
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            379..489
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            490..580
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            581..715
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            716..794
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            795..970
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1034
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..2193
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2295
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2363
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2458
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2556
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2900
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3201
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3367
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3439
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3583
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3742
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3843
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3993
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4129
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4269
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4365
                     /gene="Nrk"
                     /gene_synonym="RGD1566163"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcaggac ctgggagttg gagggacaag gaggtgacag atctcggcca cttgccggat
       61 ccaactggaa tattctcact agagaagacc attggtctcg gtacttatgg aagaatctat
      121 ttgggactcc atgaaaagac gggttctttc gtggctatta aagtaatgaa tgcccggaag
      181 actcctttgc ctgaaatagg aaagcgggtg agagtgaaca aataccgaaa gtctgtcgga
      241 tggagataca gcgatgaaga agaggatctt cggactgaac tcaacctgct gaggaagtac
      301 tctttccaca aaaacattgt gaccttctat ggtgcgttct tcaagctgaa tcctcctggc
      361 catcagcacc aactttggat ggtaatggag ctctgtgcag caggctctgt cactgatgta
      421 gtgaggatga caagaaatca gagtttaaaa gaagactgga tcgcttacat ctgtcgagaa
      481 atccttcagg gcttagctca ccttcatgcg caccaagtaa tccaccggga catcaaaggt
      541 cagaatgtgc tactgaccca ggatgctgaa gtcaagatag tggattttgg agtgagtgcc
      601 caagtgagca gaacaaatgg acggagaaat agcttcattg gtacaccgta ctggatggcc
      661 cccgaggtga ttcattgtga tgaggaccca agacgttcct atgattacag agtgactctg
      721 tgtaaccttc agcccctgga agcccttttt gttattctac gggaagctgc tcccacagtc
      781 aaatccagtg gatggtcccg taagttccag aatttcatgg aaaattgcat gataaaaaat
      841 ttcctatttc gtcctacatc tggaaacatg cttcatcacc catttgtcca cgatataaaa
      901 aatgaacgac gtgttgtgga gtcattgacc aagcacctta ctgggatcat ccaaaagaga
      961 gagagaaaag gaatacctct ggccttcgaa ggagaagaag ctgttaacga acaatacatc
     1021 acaaggagat tcagaggacc ttcttgcact cctgaacttc tgagagtgcc aaccagcagc
     1081 cgatgcagac cactcagagt cctgcatgga gagcctcctc agccaaggtg gttacctgat
     1141 gaagaacagc cagaggacca agagcttcag caactgcagg aggcagccag gatgttcatg
     1201 cctctacatt ctcaggacaa aacacttaag cctttacaaa agcaggctca gttaccacag
     1261 catctacatg tggcccctca agtgctgatg ccagtacagg ttgaagcaac agtagctacg
     1321 cctctagcta aaaagattcg ggcacctccc caactaagca aagcagcttg gggactcacg
     1381 tcaccaccta gtcaggataa caaagctagt tctcctgagg tacaggcccc catacccaga
     1441 gaacagcagg cccagaatga tgccttagaa acggaacagc ctgaagattt ggaccaggtg
     1501 ccagaagaat ttcaggggca agacagggca gctgaggagc aaaggcaggg ccaggccgct
     1561 gaacaagagc agaggcagaa tggagtccct gagcagcatc cagaggagaa tagggaacct
     1621 gaacaagctg aggtgcagga agaggctgtt gagcctccac aagctgaggt tgaggagaag
     1681 gatcctgagg taatacaagt acatgcccgg gtgttcctgc ctttacagtc ccagaaccat
     1741 catgtgttct tgcctcttca tctggacaca cagctgctaa ttccagtagg ggaacaaaat
     1801 gaagaggcac ctcgggcaca ggcctgggat ctggaggcct caagggcagc tggtgcagta
     1861 caagcactgg tagagggact atcaagagac ttgcttcgag caccaaacgc atttacctca
     1921 aaaccacttg gtccactgca aatcttgttg gaaagtttgt gcaccaacgg gttttacact
     1981 gaacctgaag cagtacagaa gaaaaagtca agagtttcta gcctgaagaa agcaatagta
     2041 aaaagactaa cacccaagag gttcagggca aaggcattat ggagacgtca agattttgaa
     2101 tgctcagatg tagaaagcag caggagacgg cgccagcgta gatgggagga aatctttaat
     2161 cagcatgaag agcaactgag ggaagttgaa aatgatagag acgatgatga ctcatcagac
     2221 aatgatgaag tgtttcattc aattcaggct gaagtccaaa tagaaccata cgctccaaat
     2281 cgtacaggaa atgaggtcca agagagatct gctcctatgc cttgcaaccg gaatcgtaca
     2341 catcgtgtga aattttctcc aagtgtctgt gagcaggctc ttttggaaga agctcagcag
     2401 ccgatggaca tcagaccgag gaactcccta aatcctcgga attttcaagc agaatcagag
     2461 tcatcttctg aggaggacag ccctgtgact aggaggaagt cccagtcatc gccgccttat
     2521 tctactattg atcagaggtt actgattgat atccatgttc cagatggatt taaagtggga
     2581 aaaatatcac cccctgtgta cttgacaaac gaatgggtag gctgtaaccc actctctgaa
     2641 gtcttctggg atgattgggt aaaccctaca cctgccacta ggcgacatga agaagatggt
     2701 gattatgttg aactctatga tgctgatgct aatggtgatg gacgagcttc aaattatgct
     2761 tatgaagaaa actatgccag tggccatgat gacatgaatc atcaggcaaa tggctataga
     2821 ggccatggta accgtcacta cagtgatggg tcttttcgaa acagaggtga tagtcgtggt
     2881 gctgctttca atgggccaag ggcaagttat tgcagagggg gaatcttgaa gaatgctggt
     2941 aatgatggcc gtgatctaag gcgaggggct ttcagagcct atggagacaa tgaagccagc
     3001 aattaccatg gagctgccag tggagcaagc gcagcctttg gaagccagga aggacatgaa
     3061 ggccacatgg gcggtcgacg aggtaacaga tacagggaag tcaatggaag cagcggagag
     3121 aatggcgcat gtggattcca tagagatggg gcaggactgg atcaacaaca tgtattccca
     3181 gattttgaaa atgaacaaga gcaatcagat gctggaactg agacgtcaga ttcaattgcc
     3241 ctggagatca catccttttc ccttgatggt gagcaaaaca atgatagagc agaaccaaca
     3301 ttgggttttc ctctcagacg ctcatcttcc agaggttctg cttcggatac tgacattatg
     3361 agtgactcat ataacaaacc aataatccat gcgtatgaaa gggaattctc gcatgaaatc
     3421 ttctgtggtt ctctgtgggg agtcaatttg ttgctgggca ccaaatctca tctgtatctg
     3481 atggacagaa gtggaaaggc agaaatcatt aaacttgtaa aacgaagacc attccgccag
     3541 attcaagtcg tggagcagct caatttgctg attaccatct ctggccgcaa gaacagactt
     3601 cgcgtgtatc atctgacttg gctgaggaac aagattctga ataatgatcc agaaagtaag
     3661 aaaaggcaga aagcaatgct gaagagagag aaagcctgca aatctctgga taagttgatt
     3721 ggctgtgaac acttcagtat ccttcatcat gaagaaacaa catacattgc aattgctttg
     3781 aaatcatcaa ttcacctgta tgcgtgggca ccaaaatcct tcaatgaaag cactgccatt
     3841 aaagtgtttc caactcatga tcttaagcca gtgacagttg acctggctgt tggttctgag
     3901 aaaacactga agattttctt cagctcagct aatggatacc acatcatcga tgcagaatct
     3961 gaagttatgt ctgatgtgac cttgccaagt aataatgtca tccttttacc tgattccttg
     4021 ggagttggag tgatgctgtc cttcaatgat gaaactgccc ctgaggaagc aaatgaacag
     4081 cttctcaaga agatcctgga cgtgtggaaa gacataccgt cttctgcggc ttttgagtgt
     4141 acacagagaa tcactggatg ggaccaaaag gctgttgaag tgcgctctct gcaggcaact
     4201 attcttgaga atgagctgaa gcgccgctca atcaagaagc tgagatttct gtgttctcgt
     4261 ggggacaagc tgttctttgc ttctctactg aacaatgagc acagcctggt ttactatgtg
     4321 agcattgcaa aacttgaagc gctccaaaga agatatgctg tttaa
//
LOCUS       NM_001008512            1020 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus trace amine associated receptor 2 (Taar2), mRNA.
ACCESSION   NM_001008512 XM_220097
VERSION     NM_001008512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1020)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY702316.1.
            
            On Dec 16, 2004 this sequence version replaced XM_220097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY702316.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WIST/Crl"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1020
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="trace amine associated receptor 2"
                     /db_xref="GeneID:294121"
                     /db_xref="RGD:1311240"
     CDS             1..1020
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="G-protein coupled receptor 58; taR-2; trace amine
                     receptor 2"
                     /codon_start=1
                     /product="trace amine-associated receptor 2"
                     /protein_id="NP_001008512.1"
                     /db_xref="GeneID:294121"
                     /db_xref="RGD:1311240"
                     /translation="MTSFEAQQETFDCSEYGNGSCPENERSLGVRAAMYSLMAGAIFI
                     TIFGNLVMIISISYFKQLHTPTNLLILSMAVTDFLLGFTIMPYSMVRSVENCWYFGLT
                     FCKIHYSFDLMLSITSIFHLCSVAIDRFYAICHPLHYCTKMTIPVVKRLLLVCWSVPG
                     AFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFVAGFFTPSSMMVGIYG
                     KIFAVSKKHARVIDNLPENQNNQMRKDKKAAKTLGIVMGVFLLCWFPCFFTILLDPFL
                     NFSTPAILFDALTWFGYFNSTCNPLIYGFFYPWFRRALRYILLGKIFSSHFHNTNLFT
                     QKETE"
     misc_feature    52..54
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD25.1); glycosylation site"
     misc_feature    97..942
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    97..942
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="trace amine-associated receptors 2, 3, 4, and
                     similar receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_TAAR2_3_4; cd15312"
                     /db_xref="CDD:320437"
     misc_feature    97..177
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    97..177
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320437"
     misc_feature    109..171
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    196..276
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    196..276
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320437"
     misc_feature    202..264
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    310..402
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    310..402
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320437"
     misc_feature    order(319..321,331..336,343..348,571..573,592..594,
                     601..606,613..615,787..789,796..801,808..810,853..855,
                     865..867,877..879)
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    order(319..321,331..336,343..348,571..573,592..594,
                     601..606,613..615,787..789,796..801,808..810,853..855,
                     865..867,877..879)
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320437"
     misc_feature    319..381
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    436..507
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    436..507
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320437"
     misc_feature    451..513
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    580..669
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    580..669
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320437"
     misc_feature    586..648
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    730..819
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    730..819
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320437"
     misc_feature    754..816
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     misc_feature    829..831
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5QD25.1); glycosylation site"
     misc_feature    844..921
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    844..921
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320437"
     misc_feature    862..930
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QD25.1);
                     transmembrane region"
     exon            1..24
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /inference="alignment:Splign:2.1.0"
     exon            25..1020
                     /gene="Taar2"
                     /gene_synonym="Gpr58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacatctt ttgaagccca acaggaaacc ttcgattgtt cagaatatgg gaatggatct
       61 tgcccagaga atgaaaggtc tctgggggtc cgagctgcaa tgtactcact gatggcagga
      121 gccatcttca tcacgatctt tggcaacctg gtcatgatca tttccatttc ctacttcaag
      181 cagcttcaca caccgaccaa cctcctcatt ctctccatgg ctgtcaccga cttcctgttg
      241 ggattcacca tcatgccata cagtatggtc cggtcagtgg aaaactgctg gtattttggg
      301 cttacctttt gcaagatcca ttatagcttt gacctgatgc ttagcataac gtccattttc
      361 cacctttgct cggtggccat agatagattt tacgccatct gtcacccttt gcattattgc
      421 accaaaatga ctattccggt cgtcaagcgg ctgctgctcg tctgctggtc agtccccggg
      481 gcgtttgcct ttggggtggt cttttcagag gcttatgctg atgggattga aggctatgac
      541 attttggttg catgttccag ttcctgccca gtcatgttta acaagctctg ggggaccacc
      601 ttatttgtgg cgggcttttt tactccgagc tccatgatgg tggggattta tggcaaaatt
      661 ttcgcagtat ccaaaaaaca tgctcgcgta attgacaact tgccagaaaa tcaaaataat
      721 caaatgagga aggacaaaaa ggcagccaaa accttgggga tagtgatggg tgttttctta
      781 ctgtgttggt ttccatgttt cttcacgatc ctgctagatc cgtttctgaa tttctctacg
      841 cctgcaattc tgtttgatgc cttaacttgg ttcggctatt ttaattccac atgtaatccc
      901 ttaatttatg gtttcttcta cccctggttt cgcagagcac tcaggtacat tttgctgggt
      961 aaaattttca gctcacattt ccacaacact aatttgttta cgcaaaaaga aacagaatag
//
LOCUS       NM_001099482            2583 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 25 (Vom2r25), mRNA.
ACCESSION   NM_001099482 XM_577748
VERSION     NM_001099482.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001099482.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  72940972-72941186
            216-507             JAXUCZ010000001.1  72958122-72958413
            508-1314            JAXUCZ010000001.1  72958761-72959567
            1315-1539           JAXUCZ010000001.1  72960159-72960383
            1540-1663           JAXUCZ010000001.1  72961356-72961479
            1664-2583           JAXUCZ010000001.1  72982724-72983643
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2583
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="vomeronasal 2 receptor, 25"
                     /db_xref="GeneID:502286"
                     /db_xref="RGD:1564853"
     CDS             1..2583
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 25 precursor"
                     /protein_id="NP_001092952.3"
                     /db_xref="GeneID:502286"
                     /db_xref="RGD:1564853"
                     /translation="MLFSWTFISCFLQIPILVCSYTSSECLVRMNYRIHGEGNVVIIG
                     YFPAYAIYPLNKTTDWRMLKFNRDFMVEIKLKNYQCILAMMFAIEEINNNPYLLPNTS
                     LGFEVNNISQGQRYTLANVFRSLSTSACVDLNYRNAHESNFAAVLTGPSWAISEYIGT
                     LLDLYKFPQLTFGPFDSLQSEQRRFSSLYQVAPKDTFLTLGIVSLMLHFHWIWVGLFI
                     IDDDKGAQTLSDLRSEMDKNGVCTAFVEMIVVTRGSFFTKSWKNQVQILESSSNVIII
                     HGDSDSLLSLIVNIKQKLLTWKVWVLISQWDVSKFDDYFMVDSLHGALIFSHHREDIP
                     NFTDFMQKSNPSKYPEDTYLHVLWHIFFNCSFVNTDCKIVHNCLPNASLGFLPGNIFD
                     MAMSEESYNVYNAVYAVAHSLHEMILNQVQFQTHEKGKKMVFFPWQLHPYLRKTLFNQ
                     DEVNEVLDWKRKSHVEYDILNFWNFPKGLGLNVKVGTFSPSAPKNQKLSISSNMIQWA
                     TGPAEIPQSVCSESCHPGFRKMHKEGIVACCFDCTPCPENEISNETDMDQCVKCPESH
                     YGDTDKIHCLQKTVTFLAYGDPWGKTLCFLSLGFSSLTAAVLGVFLKNRDTPIVKANN
                     LPLSYTLLITLMLCFLCPLLFIGHPSTASCILQQNIFGLLFTMALSTVLAKSITVVLA
                     FKITAAGRIRRWLLISRAPNFIIPLCTLLQVFLSAIWLTTSPPFVDKDAHSEHGHIII
                     ICNKGSAIAFHCTLGYLGALALASYFMAFLSRNLPDTFNEAKFLAFSMLVFCSVWVTF
                     LPVYHSTKGKVTVAMEVFSILASSTSLLGIIFVPKCYLILLRPERNSLNYIREKSYAR
                     RKKP"
     sig_peptide     1..60
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    121..1521
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1521
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(220..222,517..522,1192..1194)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(220..222,517..522,1192..1194)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,478..480,739..741)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,478..480,739..741)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1543..1701
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1543..1701
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1762..2517
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1762..2517
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1762..1839
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1762..1839
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1771..1773,1780..1785,1792..1797,1801..1806,
                     1906..1908,1918..1920,1927..1932,1954..1956,1966..1968)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1771..1773,1780..1785,1792..1797,1801..1806,
                     1906..1908,1918..1920,1927..1932,1954..1956,1966..1968)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1873..1938
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1873..1938
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1933..1935,1969..1974,1981..1986,1993..1995,
                     2233..2235,2248..2250,2257..2262,2269..2271,2371..2373,
                     2380..2385,2392..2394,2404..2406,2428..2433,2440..2442,
                     2449..2451,2461..2463)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1933..1935,1969..1974,1981..1986,1993..1995,
                     2233..2235,2248..2250,2257..2262,2269..2271,2371..2373,
                     2380..2385,2392..2394,2404..2406,2428..2433,2440..2442,
                     2449..2451,2461..2463)
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1963..2037
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1963..2037
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2107..2157
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2107..2157
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2236..2316
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2236..2316
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2338..2409
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2338..2409
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2422..2499
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2422..2499
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..215
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
     exon            216..507
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
     exon            508..1314
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1539
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1663
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2583
                     /gene="Vom2r25"
                     /gene_synonym="RGD1564853"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgttct cttggacttt tatctcttgc tttctgcaga ttccaattct tgtgtgctcc
       61 tacacaagca gcgagtgctt agtcaggatg aattaccgta tacatggtga aggaaatgtg
      121 gtgattattg gatatttccc tgcttatgcg atctaccctc tcaacaaaac cactgactgg
      181 aggatgctta aattcaacag agattttatg gttgagatta agttgaagaa ctaccaatgt
      241 attttggcta tgatgtttgc cattgaggag atcaacaaca atccctatct tttacccaac
      301 acatccctag gatttgaggt caataatatc tcacaaggtc aaaggtacac tctagccaat
      361 gtttttcgct cactttcaac atctgcatgt gttgacctta actacagaaa tgcacacgag
      421 agcaattttg ctgctgtact tacaggacca tcatgggcaa tatctgaata catagggaca
      481 cttctggatc tttacaaatt tccacagctt acttttggac cttttgatag tctccagagt
      541 gaacaaagac ggttttcttc actgtaccaa gtggctccca aggacacatt tttgacactt
      601 ggcattgtat ctttgatgct tcatttccac tggatctggg tggggttatt catcatagat
      661 gatgacaaag gtgcccagac actgtcagat ttgagaagtg agatggataa aaacggagtc
      721 tgcacagcat ttgtagaaat gatcgtagtc accagaggtt cattttttac caaatcctgg
      781 aaaaatcagg tgcagatcct ggaatcatca tcaaatgtga ttattattca tggggactct
      841 gattctctat taagcttaat agtaaatatt aagcagaagt tactcacatg gaaagtgtgg
      901 gtactgatct cacagtggga tgtttctaaa tttgatgatt atttcatggt agactcattg
      961 catggagctc ttattttttc acaccatcgt gaggatattc ccaattttac agattttatg
     1021 cagaagtcca acccttccaa gtacccggaa gacacttatc ttcatgtatt gtggcacatt
     1081 ttcttcaact gctcatttgt taacacggat tgtaaaattg tgcacaactg tttgcctaat
     1141 gcctccctgg ggttcttgcc tgggaacata tttgacatgg ccatgagtga agagagttac
     1201 aatgtgtaca atgctgtgta tgctgtggcc cacagtctgc atgagatgat tctcaaccaa
     1261 gtgcaatttc aaactcatga aaaaggaaaa aagatggtat tcttcccttg gcagcttcac
     1321 ccttatctaa ggaaaacact attcaatcag gatgaagtca atgaggttct ggattggaaa
     1381 aggaaatcac atgtagagta tgacattctc aacttttgga atttccctaa aggtcttggg
     1441 ctaaatgtga aagtaggaac attttctcca agtgctccaa agaaccagaa attgtccata
     1501 tcttctaaca tgatacagtg ggccacagga ccggcagaga ttcctcagtc tgtatgcagt
     1561 gagagctgtc atcctggatt caggaaaatg cacaaagaag gcatagttgc ctgttgcttt
     1621 gactgcaccc cttgtccaga gaatgagatt tccaatgaga cagatatgga tcagtgtgta
     1681 aagtgtccag aaagtcacta tggagacaca gacaagatcc actgcctaca gaaaactgtg
     1741 acatttctgg cttatggtga cccttggggg aagacacttt gcttcctgtc cctgggcttc
     1801 tcctcactca cagctgctgt tcttggagtg tttctgaaga acagagacac ccccattgtc
     1861 aaagccaata acctgcctct cagttacacc ctgctcatca ctctgatgct ctgttttctc
     1921 tgtccattgc tcttcattgg ccatcccagc acagcctcct gtatcctgca acaaaacatt
     1981 tttgggcttc tcttcaccat ggctctatcc actgtgttgg ctaaaagtat cactgttgtt
     2041 ttagccttta agatcactgc tgcaggaaga attagaagat ggctgctgat atcaagggcc
     2101 cctaatttca ttattccctt atgcaccctg ctccaagttt ttctttctgc aatttggctg
     2161 acaacctctc ctccatttgt tgataaagat gctcactcag aacatgggca cattatcatc
     2221 atttgcaaca aaggctcagc tattgctttc cattgcaccc tgggatacct gggagcactg
     2281 gccctagcga gctactttat ggcttttttg tcaagaaatc tacctgacac attcaatgaa
     2341 gctaagttcc tggctttcag catgctggtg ttctgcagtg tctgggttac cttcctccct
     2401 gtctaccaca gcaccaaagg gaaggtcacg gtggctatgg aagtcttttc tatcttggct
     2461 tccagtacat ctctcctagg catcatcttt gttcccaagt gctacctcat attattaagg
     2521 ccagaaagga actcactgaa ttatatcagg gaaaaatcat atgctaggag aaaaaaacct
     2581 taa
//
LOCUS       NM_001167552             948 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 60 (Vom1r60), mRNA.
ACCESSION   NM_001167552
VERSION     NM_001167552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 948)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000001.1  83135921-83136030
            111-948             JAXUCZ010000001.1  83136031-83136868
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..948
                     /gene="Vom1r60"
                     /note="vomeronasal 1 receptor 60"
                     /db_xref="GeneID:100312671"
                     /db_xref="RGD:2316470"
     CDS             1..948
                     /gene="Vom1r60"
                     /note="vomeronasal 1 receptor Vom1r60; vomeronasal 1
                     receptor, J4-like"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 60"
                     /protein_id="NP_001161024.1"
                     /db_xref="GeneID:100312671"
                     /db_xref="RGD:2316470"
                     /translation="MLPSDTIVQIFLILQFCLGVMGNSALLLLYIYTFVFRPQYKKLI
                     DSVFIHLTIVNILLIVFLLTKHIMLPFGVPNFLDDIGCKTVLFSFRVSRGLSICSTCV
                     ISTFQVITITPSTSKWAWLKPRLSTWIFSSLLCSWLINLLIYGYMLDMVIAKTNNTLV
                     GHGYTDGYCVNKQVGNHNSGSFLSIVIIHDLFFVTIMMCASLYMVLFLYRYRKGAQHL
                     RSPNLSFQPSPERKATHSILSLVSCFVLIYWLNNCVTLYSFYSSERIPRVESINAILT
                     TCYPTICPFLFMKNNKVILQFISSFSIQRMTCFQSSIHG"
     misc_feature    16..900
                     /gene="Vom1r60"
                     /note="Vomeronasal organ pheromone receptor family, V1R;
                     Region: V1R; pfam03402"
                     /db_xref="CDD:460912"
     misc_feature    16..900
                     /gene="Vom1r60"
                     /note="Vomeronasal organ pheromone receptor family, V1R;
                     Region: V1R; pfam03402"
                     /db_xref="CDD:460912"
     exon            1..948
                     /gene="Vom1r60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcttccaa gtgacactat tgtccagatc tttctcatat tgcagttctg tcttggtgtc
       61 atgggcaact cagcactatt gttgttatat atatacactt tcgtcttcag gcctcagtat
      121 aagaagttga tagattcagt tttcattcac ctgacaatag ttaatattct gctgattgta
      181 ttcctattga caaaacatat catgttaccc tttggagtac ccaattttct ggacgatatc
      241 ggttgtaaga cagttttgtt ttcattcaga gtcagccggg gtctgtccat ctgcagcacc
      301 tgtgttataa gcacattcca agtaatcacc atcactccca gtacttctaa gtgggcctgg
      361 cttaagccta gactctctac atggatcttt tcttccttac tttgctcctg gcttattaac
      421 ctactcatct atgggtatat gcttgacatg gtaattgcca aaactaataa tactcttgtt
      481 ggccatggat atacagatgg ttactgtgta aacaagcagg tggggaacca caattcaggg
      541 tcttttctta gcattgtcat cattcatgat ctcttctttg tgaccatcat gatgtgcgcc
      601 agcctctaca tggtgctttt cctctacaga taccgcaagg gagcccagca tctccgtagc
      661 ccaaatcttt ctttccagcc atcccctgag cgcaaagcca cccacagcat cctgtctctg
      721 gtgagctgct ttgtattaat ttattggttg aacaactgtg tcacccttta tagcttttat
      781 tcaagtgaaa gaattccaag agtggagtca ataaatgcga ttttgacaac atgctaccct
      841 accatctgcc cttttttatt catgaagaat aataaagtta ttttgcaatt catttcctca
      901 ttttctatac agagaatgac ctgttttcaa agttctatcc atggctaa
//
LOCUS       NM_001191072            1886 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 16B
            (Ppp1r16b), mRNA.
ACCESSION   NM_001191072 XM_001058014
VERSION     NM_001191072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Boratko,A., Peter,M., Thalwieser,Z., Kovacs,E. and Csortos,C.
  TITLE     Elongation factor-1A1 is a novel substrate of the protein
            phosphatase 1-TIMAP complex
  JOURNAL   Int J Biochem Cell Biol 69, 105-113 (2015)
   PUBMED   26497934
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Obeidat,M., Li,L. and Ballermann,B.J.
  TITLE     TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt
            inhibition in human glomerular endothelial cells
  JOURNAL   Am J Physiol Renal Physiol 307 (5), F623-F633 (2014)
   PUBMED   25007873
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Poirier,C., Gorshkov,B.A., Zemskova,M.A., Bogatcheva,N.V. and
            Verin,A.D.
  TITLE     TIMAP protects endothelial barrier from LPS-induced vascular
            leakage and is down-regulated by LPS
  JOURNAL   Respir Physiol Neurobiol 179 (2-3), 334-337 (2011)
   PUBMED   21907835
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Czikora,I., Kim,K.M., Kasa,A., Becsi,B., Verin,A.D., Gergely,P.,
            Erdodi,F. and Csortos,C.
  TITLE     Characterization of the effect of TIMAP phosphorylation on its
            interaction with protein phosphatase 1
  JOURNAL   Biochimie 93 (7), 1139-1145 (2011)
   PUBMED   21466834
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Csortos,C., Czikora,I., Bogatcheva,N.V., Adyshev,D.M., Poirier,C.,
            Olah,G. and Verin,A.D.
  TITLE     TIMAP is a positive regulator of pulmonary endothelial barrier
            function
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 295 (3), L440-L450 (2008)
   PUBMED   18586956
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Kim,K., Li,L., Kozlowski,K., Suh,H.S., Cao,W. and Ballermann,B.J.
  TITLE     The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1
            phosphorylation
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1327-1334 (2005)
   PUBMED   16263087
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Cao,W., Mattagajasingh,S.N., Xu,H., Kim,K., Fierlbeck,W., Deng,J.,
            Lowenstein,C.J. and Ballermann,B.J.
  TITLE     TIMAP, a novel CAAX box protein regulated by TGF-beta1 and
            expressed in endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 283 (1), C327-C337 (2002)
   PUBMED   12055102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001058014.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.15404.1,
                                           SRR26643284.5111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  167743991-167744070
            81-429              JAXUCZ010000003.1  167771689-167772037
            430-500             JAXUCZ010000003.1  167815666-167815736
            501-646             JAXUCZ010000003.1  167822013-167822158
            647-750             JAXUCZ010000003.1  167824350-167824453
            751-875             JAXUCZ010000003.1  167826229-167826353
            876-1001            JAXUCZ010000003.1  167828233-167828358
            1002-1077           JAXUCZ010000003.1  167828902-167828977
            1078-1207           JAXUCZ010000003.1  167830038-167830167
            1208-1376           JAXUCZ010000003.1  167830257-167830425
            1377-1886           JAXUCZ010000003.1  167834743-167835252
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1886
                     /gene="Ppp1r16b"
                     /note="protein phosphatase 1, regulatory subunit 16B"
                     /db_xref="GeneID:680616"
                     /db_xref="RGD:1589460"
     exon            1..80
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            81..429
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    90..92
                     /gene="Ppp1r16b"
                     /note="upstream in-frame stop codon"
     CDS             180..1886
                     /gene="Ppp1r16b"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 16B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory inhibitor
                     subunit 16B"
                     /protein_id="NP_001178001.1"
                     /db_xref="GeneID:680616"
                     /db_xref="RGD:1589460"
                     /translation="MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDL
                     LHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGL
                     TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADL
                     LAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAA
                     GQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMP
                     MAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSR
                     RTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEEQRTSTYNGDIRETRT
                     DQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHE
                     IPDYSMAYGNPGMADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVA
                     RSGEGSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCR
                     IS"
     misc_feature    390..1142
                     /gene="Ppp1r16b"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    390..1142
                     /gene="Ppp1r16b"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    390..473
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    390..473
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(396..401,408..416,420..425,435..437,444..446,
                     471..473,477..479,483..485,495..500,507..515,519..524,
                     534..536,543..545,570..572,576..578,582..584,594..599,
                     606..614,618..623,633..635,642..644,669..671)
                     /gene="Ppp1r16b"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(396..401,408..416,420..425,435..437,444..446,
                     471..473,477..479,483..485,495..500,507..515,519..524,
                     534..536,543..545,570..572,576..578,582..584,594..599,
                     606..614,618..623,633..635,642..644,669..671)
                     /gene="Ppp1r16b"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    477..572
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    477..572
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    576..671
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    576..671
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    675..956
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    675..956
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    960..1055
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    960..1055
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1059..1133
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1059..1133
                     /gene="Ppp1r16b"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            430..500
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            501..646
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            647..750
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            751..875
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1001
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1077
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1376
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1886
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcaccacc agctgcggct ctgggacctg cggattgagc cggggctggg agccgcccgg
       61 ggcagggctc gagagagcgg gccccaccat gaggctccag cccctcggga gcccctgtgc
      121 tcccctggcc ccgggctcac ggtgctagcc ccagacagag caagggcagg tgcggggcca
      181 tggccagcca cgtggacctg ctcacagagc tgcagctgct ggagaaggtg cctacactgg
      241 agcgcctgcg cgcagcccag aagcgccggg ctcagcagct gaagaagtgg gcacagtatg
      301 agcaggacct gcttcatcgc aagcgcaagc atgagcggaa gcgtagcacc ggtggacgtc
      361 gcaagaaggt gtccttcgag gccagtgtag cgttgctgga ggcctcactg aggaatgacg
      421 ctgaagaagt acgatacttc ctgaagaaca aggtcagccc tgatttgtgt aatgaggatg
      481 ggctcacagc cttgcaccag tgctgcattg acaacttcga agagattgtg aaactgttgc
      541 tctcccatgg tgcaaacgtg aacgccaagg acaacgagtt gtggacaccc ttgcacgctg
      601 cagccacctg cggccacatc aacctagtga agatcctcgt tcagtatggg gctgacttgc
      661 ttgctgtcaa ctctgatggg aacatgccct atgacctctg cgaggatgaa cccaccctgg
      721 atgtcatcga gacctgcatg gcgtaccaag gcatcaccca ggagaaaatc aatgagatgc
      781 gagcagctcc tgagcagaag atgatttcgg acatccactg catgatagca gccggccagg
      841 atctcgactg gatagatggc cagggtgcca cactgctaca catagctgga gccaatggat
      901 acctgcgggc agccgagctc ctcctggacc acggagtgcg tgtggacgtc aaggattggg
      961 atggctggga gcctctgcat gcagcagcct tctggggaca gatgccaatg gcagagctct
     1021 tggtgtccca tggagctagt ctcagtgcca ggacatccat ggatgagatg ccaatagact
     1081 tgtgtgagga ggaggaattc aaagtcctgc tgttggagct taaacacaag catgatgtaa
     1141 tcatgaagtc ccagctgaga cacaagtcat ccctgagccg gaggacatcc agtgcaggca
     1201 gccgtgggaa ggtggtgcgt cgagccagcc tgtcagacag aaccaaccta taccggaaag
     1261 aatatgaagg agaggccatc ttgtggcagc agcggagtgc agctgaggaa cagcgtactt
     1321 ccacctacaa cggagacatc agggagacca ggacagacca ggagaacaag gacccgaacc
     1381 ccaggctgga gaagcccgtg ctgctttcag aattctctac caagatctcc cggggagaac
     1441 tggatgggcc tgtggagaat ggcctccggg ctcctgtcag cacctaccag tatgcgctgg
     1501 ccaacgggga catatggaag atgcacgaga tacctgacta cagcatggcc tatggcaacc
     1561 ccggcatggc tgatgtcccc ccaccctgga gcggcttcaa agagcagagc ccccagacgc
     1621 tcctggagct gaagaggcag agggccgcag ccaagttgct cagccacccg ttcttaagca
     1681 cccacctggg cagcagtgtg gccaggtcgg gggagggcag cagcgaaggc aaggccccct
     1741 tgatcggagg cagaacttcc ccctacagca gcaacgggac ctcggtgtat tatacggtca
     1801 ccagcggaga tcccccgctc ttgaagttca aggcccccat ggaggagatg gaggagaaag
     1861 ttcacggctg ctgccggatc tcctaa
//
LOCUS       NM_001191829            1077 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus glycoprotein A33 (Gpa33), mRNA.
ACCESSION   NM_001191829 XM_341149
VERSION     NM_001191829.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Abud,H.E., Johnstone,C.N., Tebbutt,N.C. and Heath,J.K.
  TITLE     The murine A33 antigen is expressed at two distinct sites during
            development, the ICM of the blastocyst and the intestinal
            epithelium
  JOURNAL   Mech Dev 98 (1-2), 111-114 (2000)
   PUBMED   11044613
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Jul 17, 2010 this sequence version replaced XM_341149.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.34164.1,
                                           SRR26643288.49767.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000013.1  80914119-80914278
            161-315             JAXUCZ010000013.1  80930317-80930471
            316-532             JAXUCZ010000013.1  80934324-80934540
            533-688             JAXUCZ010000013.1  80939167-80939322
            689-808             JAXUCZ010000013.1  80945934-80946053
            809-944             JAXUCZ010000013.1  80947043-80947178
            945-1077            JAXUCZ010000013.1  80947606-80947738
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..1077
                     /gene="Gpa33"
                     /note="glycoprotein A33"
                     /db_xref="GeneID:360873"
                     /db_xref="RGD:1306711"
     exon            1..160
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1077
                     /gene="Gpa33"
                     /note="cell surface A33 antigen; glycoprotein A33
                     (transmembrane)"
                     /codon_start=1
                     /product="cell surface A33 antigen precursor"
                     /protein_id="NP_001178758.1"
                     /db_xref="GeneID:360873"
                     /db_xref="RGD:1306711"
                     /translation="MLGTVGPVLWMFCAIWVAADAITVETTQDVLRAARGKSVTLPCI
                     YSTPVSDRQGFIQWDKLLRSQTEKVATWTFETKKYTYGSRYENRVRISNDAELSNASI
                     TIDQLTMDDNGTYECSVSLMSDQDVTSRSRVRLLVLVPPSKPDCGIEGETVIGNNIQL
                     TCHSAEGSPSPQYSWKSYNAQNQQRPLAQPVSGEPLLLKNISADTAGYYICTSSNDVG
                     TEFCNITVAPRPPSMNIALYAGIAGGVFVALIIIGVIVYCCCCREKDDKAQEMETVRP
                     DRAAYQEPKNQRTEISREWEDEDDRRHEDQRSSGRGSPDQPFQ"
     sig_peptide     118..180
                     /gene="Gpa33"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    193..531
                     /gene="Gpa33"
                     /note="Immunoglobulin V-set domain; Region: V-set;
                     pfam07686"
                     /db_xref="CDD:462230"
     misc_feature    193..531
                     /gene="Gpa33"
                     /note="Immunoglobulin V-set domain; Region: V-set;
                     pfam07686"
                     /db_xref="CDD:462230"
     misc_feature    532..777
                     /gene="Gpa33"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    532..777
                     /gene="Gpa33"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    574..603
                     /gene="Gpa33"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    574..603
                     /gene="Gpa33"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    631..645
                     /gene="Gpa33"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    631..645
                     /gene="Gpa33"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    697..711
                     /gene="Gpa33"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    697..711
                     /gene="Gpa33"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    739..756
                     /gene="Gpa33"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    739..756
                     /gene="Gpa33"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     exon            161..315
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     exon            316..532
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     exon            533..688
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     exon            689..808
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     exon            809..944
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1077
                     /gene="Gpa33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcaccgg gacgacagac tgaatcgggc cagagggtag ctttaaccag acagcccaga
       61 cctgtccagt gccttgccgg ttccagactg ggtttgtgtc agaaaaggag caagaccatg
      121 ttggggacgg tgggacctgt gctgtggatg ttctgtgcga tctgggtggc tgctgatgct
      181 attactgtgg aaaccacaca ggacgttctt cgggctgctc gaggaaagag tgtcaccctc
      241 ccatgcatct acagcactcc tgtttcagac cgacagggat tcattcagtg ggataagctt
      301 ctcagaagtc aaacggaaaa agtggccacc tggacttttg agacgaagaa atacacctat
      361 gggagccgtt atgagaaccg cgtgagaata tctaacgatg ccgagctgtc gaacgcctct
      421 atcaccatcg accagctgac catggatgac aatggcacct acgagtgctc cgtctcactg
      481 atgtcagacc aggatgtcac ctccaggtct cgagtccgcc tcttagtcct cgtaccaccc
      541 tccaagccag actgcggcat cgaaggggag acagtgattg ggaacaacat ccaactgaca
      601 tgtcattctg cagagggctc tccgagccca cagtacagct ggaaaagtta caatgcccag
      661 aaccagcagc ggccactagc ccagccagtc tcaggcgagc ccttgcttct gaagaacatc
      721 tccgcggata cagcgggtta ctacatctgc acctccagca atgacgtggg cacagagttc
      781 tgcaacatca ccgtggcacc cagacctccc tccatgaaca ttgcactgta tgcgggcatt
      841 gcggggggtg tctttgtggc cctcatcatc atcggggtca tcgtctactg ctgctgttgc
      901 cgggaaaaag atgacaaagc tcaagaaatg gagaccgtgc gaccggaccg agcagcttac
      961 caagagccta aaaaccagcg gacagaaatt tccagagagt gggaagatga ggatgaccgc
     1021 aggcatgagg accagaggag ctcagggcgt ggctctccag accagccttt ccagtga
//
LOCUS       NM_001409148             933 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus olfactory receptor family 5 subfamily P member 80
            (Or5p80), mRNA.
ACCESSION   NM_001409148 XM_039096441
VERSION     NM_001409148.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Jul 12, 2022 this sequence version replaced XM_039096441.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               JAXUCZ010000001.1  171942039-171942971
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..933
                     /gene="Or5p80"
                     /note="olfactory receptor family 5 subfamily P member 80"
                     /db_xref="GeneID:687082"
                     /db_xref="RGD:1590087"
     CDS             1..933
                     /gene="Or5p80"
                     /note="olfactory receptor 508"
                     /codon_start=1
                     /product="olfactory receptor family 5 subfamily P member
                     80"
                     /protein_id="NP_001396077.1"
                     /db_xref="GeneID:687082"
                     /db_xref="RGD:1590087"
                     /translation="MESGNYTVVTELILLGFAEDATVRAILFVVFLIIYSVTLIGNMS
                     IIMLIRRSSQLHTPMYLFLSHLAFVDIGYSSSVTPIMLKGFLRKEISILVAGCVTQLY
                     FAVTFGSVECFLLAAMAYDRYVAICSPLLYATQMSSTVCILLVGASYLGGCVNAWTFT
                     GCLLNLSFCRPNKVNHFFCDYSPLLKISCSHGFSSEVIPAISSGSIIVVTVFIIALSY
                     VYILVSILKMRSPEGRQKAFSTCTSHLTAVTLFYGTITFIYVMPKSSYSTDQNKVVSV
                     FYTVVIPMLNPIIYSLRNKDVKEAMKKLMADTHW"
     misc_feature    73..909
                     /gene="Or5p80"
                     /note="olfactory receptor subfamily 5P and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR5P-like; cd15416"
                     /db_xref="CDD:320538"
     misc_feature    73..909
                     /gene="Or5p80"
                     /note="olfactory receptor subfamily 5P and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; Region:
                     7tmA_OR5P-like; cd15416"
                     /db_xref="CDD:320538"
     misc_feature    76..156
                     /gene="Or5p80"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320538"
     misc_feature    76..156
                     /gene="Or5p80"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320538"
     misc_feature    175..255
                     /gene="Or5p80"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320538"
     misc_feature    175..255
                     /gene="Or5p80"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320538"
     misc_feature    order(241..243,250..255,289..306,310..315,322..324,
                     457..459,463..477,583..585,592..600,604..612,616..621,
                     754..756,763..768,772..777,784..786,802..807,811..819,
                     826..828,835..840)
                     /gene="Or5p80"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320538"
     misc_feature    order(241..243,250..255,289..306,310..315,322..324,
                     457..459,463..477,583..585,592..600,604..612,616..621,
                     754..756,763..768,772..777,784..786,802..807,811..819,
                     826..828,835..840)
                     /gene="Or5p80"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320538"
     misc_feature    289..381
                     /gene="Or5p80"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320538"
     misc_feature    289..381
                     /gene="Or5p80"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320538"
     misc_feature    418..483
                     /gene="Or5p80"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320538"
     misc_feature    418..483
                     /gene="Or5p80"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320538"
     misc_feature    583..675
                     /gene="Or5p80"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320538"
     misc_feature    583..675
                     /gene="Or5p80"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320538"
     misc_feature    694..786
                     /gene="Or5p80"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320538"
     misc_feature    694..786
                     /gene="Or5p80"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320538"
     misc_feature    805..882
                     /gene="Or5p80"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320538"
     misc_feature    805..882
                     /gene="Or5p80"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320538"
     exon            1..933
                     /gene="Or5p80"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaatctg gaaactacac agtggtgaca gaattgattc ttttggggtt tgcagaggat
       61 gctacggtcc gtgccatttt atttgttgtg tttctaataa tctactctgt caccttaata
      121 ggcaatatga gtataatcat gctaatcaga agaagttctc agcttcacac gcccatgtac
      181 cttttcctca gccatttggc atttgtagac attgggtact cctcatcagt cacgcccatt
      241 atgctgaagg gctttctcag gaaagaaata tctatccttg tggctggctg tgtgactcaa
      301 ctctattttg cagtgacatt tggatcagtt gagtgcttcc tgctggctgc catggcctat
      361 gaccgctatg tagctatctg ctcacctctg ctctatgcca cacagatgtc ctccacagtt
      421 tgtattctcc tagtgggagc ttcctaccta ggtggatgtg tgaatgcttg gacatttact
      481 ggatgtttat taaatctgtc tttttgtaga ccaaataaag ttaatcactt tttttgtgac
      541 tattcaccac tgttgaagat ttcatgttct catggatttt cttctgaagt cattccagca
      601 atctcttcag gctcaatcat tgtggtaact gtgtttatca ttgcactgtc ttatgtttac
      661 atccttgtat caatcctgaa gatgcggtcc cctgagggcc gccagaaggc cttctcaacc
      721 tgcacctccc acctcactgc tgtcactctg ttctatggaa ccatcacatt catttatgtg
      781 atgcccaaat ccagttactc cacagaccaa aacaaggtgg tgtctgtatt ctacacagtg
      841 gtaatcccaa tgttgaaccc catcatctat agcctcagaa acaaggatgt taaagaggct
      901 atgaaaaaat tgatggctga cacacactgg tag
//
LOCUS       NM_001191835             613 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus complexin 4 (Cplx4), mRNA.
ACCESSION   NM_001191835 XM_341625
VERSION     NM_001191835.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 613)
  AUTHORS   Reim,K., Wegmeyer,H., Brandstatter,J.H., Xue,M., Rosenmund,C.,
            Dresbach,T., Hofmann,K. and Brose,N.
  TITLE     Structurally and functionally unique complexins at retinal ribbon
            synapses
  JOURNAL   J Cell Biol 169 (4), 669-680 (2005)
   PUBMED   15911881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jul 17, 2010 this sequence version replaced XM_341625.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB748805.1, CB801796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000018.1  61767458-61767754   c
            298-385             JAXUCZ010000018.1  61765004-61765091   c
            386-613             JAXUCZ010000018.1  61751991-61752218   c
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..613
                     /gene="Cplx4"
                     /note="complexin 4"
                     /db_xref="GeneID:361342"
                     /db_xref="RGD:1307643"
     exon            1..297
                     /gene="Cplx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..613
                     /gene="Cplx4"
                     /codon_start=1
                     /product="complexin-4"
                     /protein_id="NP_001178764.1"
                     /db_xref="GeneID:361342"
                     /db_xref="RGD:1307643"
                     /translation="MAFFVKNMISNQVKNLGFGGGSEEKKEEGGTSDPAAAKGMTREE
                     YEEYQKQMIEEKMERDAAFTQKKAERACLRVHLRDKYRLPKSEMDETQIQLAGDDVDL
                     PEDLRKMVDEDQDEEEEKDSILGQLQNLQNMDLDTIKEKAQATFTEIKQSAEQKCSVM
                     "
     misc_feature    131..550
                     /gene="Cplx4"
                     /note="Synaphin protein; Region: Synaphin; pfam05835"
                     /db_xref="CDD:461755"
     misc_feature    131..550
                     /gene="Cplx4"
                     /note="Synaphin protein; Region: Synaphin; pfam05835"
                     /db_xref="CDD:461755"
     exon            298..385
                     /gene="Cplx4"
                     /inference="alignment:Splign:2.1.0"
     exon            386..613
                     /gene="Cplx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggctgc gcaaatcctc cgctcccaaa tgtgtggctg tggctgaaaa tatttgaagg
       61 ttttgctttg gtttcgttgg gttcttttgg gcgatctttg actgggtttt ggttctccaa
      121 ggccgagaca atggctttct ttgtgaaaaa tatgataagt aaccaggtaa agaatttagg
      181 atttggaggt gggtctgaag aaaagaaaga agaaggaggc acctcagacc ccgcggcggc
      241 taaagggatg actagagagg aatacgagga ataccagaag cagatgattg aagagaagat
      301 ggagagagat gctgcattta ctcagaaaaa ggctgagagg gcatgcctac gagtccacct
      361 cagagacaaa tacaggcttc cgaagagtga aatggacgag acacaaatcc agctggctgg
      421 ggacgatgtg gatttgcccg aggatctccg aaagatggta gacgaggacc aggatgagga
      481 agaggagaag gattctatcc tggggcagtt gcagaacctc cagaacatgg acttggatac
      541 cattaaagag aaggcacaag ccaccttcac agaaatcaag cagtcagccg aacagaagtg
      601 ttctgtgatg tga
//
LOCUS       NM_001099457            2037 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 2 (Vom2r2), mRNA.
ACCESSION   NM_001099457 XM_218099
VERSION     NM_001099457.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 31, 2024 this sequence version replaced NM_001099457.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-804               JAXUCZ010000001.1  1167632-1168435     c
            805-1029            JAXUCZ010000001.1  1166555-1166779     c
            1030-1153           JAXUCZ010000001.1  1165224-1165347     c
            1154-2037           JAXUCZ010000001.1  1161262-1162145     c
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..2037
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="vomeronasal 2 receptor, 2"
                     /db_xref="GeneID:292438"
                     /db_xref="RGD:1561757"
     exon            1..804
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2037
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 2"
                     /protein_id="NP_001092927.3"
                     /db_xref="GeneID:292438"
                     /db_xref="RGD:1561757"
                     /translation="MVSLMFHFEWTWIGLIITDDDQGIQFHSDLREEMQRHAICLAFV
                     IMIPESIKLYNTKFKIYDQQLMTSSAKVTIIYGKMISTLELNFARWTYLVARRIWITT
                     SKLDVITYDKDFSLDFFHGTVIFAHHHNDIATFRNFMQIINTSKYPVDISQSMGQWNH
                     FNCSISKNKKKMDFFMLKNPMEWLTQHTFDMVLSEEGYNLYNAVYAVAHTYHELIFQQ
                     VESQEMAKPKGLFTDCQQVASLLKTRVFTNPVGELVNMNHKENQCAKYDIFIIWNFPN
                     GLGLKVKIGSYFPCLQQSQHLHISEDWEWVTGETLVPSSVCSETCTAGFRKSHQKQTA
                     NCCFDCVQCQENEIANDTDMEQCVRCPDDSYANLEQTQCLQRAVTFLAYEDPLGMALG
                     CMALSFSAITVLVLVTFVKYRDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQA
                     TCILQQATFAIFFTVAISTVLAKTITVVTAFKLTTPGRRIRKMMIKGATHLLIPICTL
                     IQLVLCAIWLVTSPPFIDRDIQSEHGKVIIICNKGSVIAFHFVLGYLGSLALGSFTVA
                     FLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYHSTRGKVMVIVEVFSILASSAGLL
                     GCIFVQKCYVLLVRPDLNVLQK"
     misc_feature    <97..1011
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    <97..1011
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1033..1194
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1033..1194
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1252..2007
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1252..2007
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1252..1329
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1252..1329
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1261..1263,1270..1275,1282..1287,1291..1296,
                     1396..1398,1408..1410,1417..1422,1444..1446,1456..1458)
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1261..1263,1270..1275,1282..1287,1291..1296,
                     1396..1398,1408..1410,1417..1422,1444..1446,1456..1458)
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1363..1428
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1363..1428
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1423..1425,1459..1464,1471..1476,1483..1485,
                     1723..1725,1738..1740,1747..1752,1759..1761,1861..1863,
                     1870..1875,1882..1884,1894..1896,1918..1923,1930..1932,
                     1939..1941,1951..1953)
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1423..1425,1459..1464,1471..1476,1483..1485,
                     1723..1725,1738..1740,1747..1752,1759..1761,1861..1863,
                     1870..1875,1882..1884,1894..1896,1918..1923,1930..1932,
                     1939..1941,1951..1953)
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1453..1527
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1453..1527
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1597..1647
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    1597..1647
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    1726..1806
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    1726..1806
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    1828..1899
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    1828..1899
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    1912..1989
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    1912..1989
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            805..1029
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1153
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2037
                     /gene="Vom2r2"
                     /gene_synonym="RGD1561757"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttctttg gaccatttaa tcctaacctg agtgaccatg accagtttcc ctatatctat
       61 cagatagcaa ccaaggacac atatttgctc catggcatgg tctccttgat gtttcatttt
      121 gaatggactt ggataggact gatcatcaca gatgatgacc aaggtattca gtttcactca
      181 gacttgagag aagaaatgca aaggcatgcg atctgtttag cttttgtgat tatgatccca
      241 gaaagcatta agttatacaa cacaaagttt aagatatatg accaacaact tatgacatct
      301 tctgcaaagg ttactatcat ttatggcaaa atgatctcca ctctagaact caactttgca
      361 agatggacat atttagttgc acggagaatc tggatcacaa cctcaaaatt ggatgtcatc
      421 acatatgata aagatttcag ccttgatttc ttccacggga ctgtcatttt tgcccaccac
      481 cacaatgaca tcgctacatt tagaaatttt atgcaaataa taaacacatc caagtatcca
      541 gtagatattt ctcagtctat ggggcagtgg aatcatttta actgttcaat ctcaaagaac
      601 aagaagaaaa tggatttttt tatgttgaaa aacccaatgg aatggttaac acagcacaca
      661 tttgacatgg tcctgagtga agaaggttac aatttgtata atgctgtgta tgctgtggcc
      721 cacacctatc acgaactcat ttttcaacaa gtagagtctc aggaaatggc caaacccaaa
      781 ggactattca ctgactgtca gcaggtggct tctttgctta aaactagggt atttactaac
      841 cctgttggag agctggtgaa catgaatcat aaggaaaatc agtgtgccaa gtatgacatt
      901 ttcatcattt ggaattttcc aaatggcctt ggattaaaag tgaaaatagg aagctatttt
      961 ccttgtttgc aacagagtca acatcttcat atatctgaag actgggagtg ggttacagga
     1021 gaaacattgg ttccctcctc agtgtgtagt gagacatgta ctgcaggatt cagaaaaagt
     1081 catcagaaac aaacagccaa ctgctgcttt gattgtgtcc agtgccaaga aaatgagatt
     1141 gccaatgata cagatatgga gcagtgtgtg cggtgtccag atgattcata tgccaactta
     1201 gaacaaaccc agtgcctcca aagagcggtg acgtttctcg cttatgaaga tccattgggg
     1261 atggctctag gctgcatggc cctgtccttt tcagccatca cagttctagt actagtcact
     1321 tttgtgaagt acagggatac acccattgtg aaagccaata accgtattct cagctacatc
     1381 ctgctcatat ctctagtctt ctgttttctc tgctcattgc tcttcattgg acatcccaac
     1441 caggccacct gcatcctgca gcaggccacg tttgcaatat ttttcactgt ggctatttct
     1501 actgtgttgg ccaaaacaat aactgtggtc acagctttca agctcactac tccagggaga
     1561 aggataagaa agatgatgat aaaaggggca actcacttgc tcattcccat ttgtacccta
     1621 atccaacttg ttctctgtgc aatctggttg gtgacatctc ctccatttat tgacagagat
     1681 atacaatctg aacatgggaa ggtaatcatc atttgcaaca aaggctcagt cattgccttc
     1741 cactttgtct tgggatattt gggctccttg gctctgggga gcttcactgt ggctttcttg
     1801 gctaggaacc ttcctgacag attcaatgag gccaagttcc taacattcag catgttggtg
     1861 ttctacagtg tttggatcac cttcctccct gtctaccaca gcaccagggg gaaggttatg
     1921 gttattgtgg aggttttctc catcttggct tctagtgcag ggttgctagg gtgcatattt
     1981 gtccaaaagt gttatgttct tttagttcga ccagatttaa atgttcttca gaaataa
//
LOCUS       NM_001192015            1716 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 15, member 5 (Slc15a5),
            mRNA.
ACCESSION   NM_001192015 XM_578419
VERSION     NM_001192015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_578419.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2485107.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               JAXUCZ010000004.1  172702551-172702893 c
            344-563             JAXUCZ010000004.1  172696509-172696728 c
            564-733             JAXUCZ010000004.1  172683884-172684053 c
            734-957             JAXUCZ010000004.1  172670161-172670384 c
            958-1144            JAXUCZ010000004.1  172663876-172664062 c
            1145-1327           JAXUCZ010000004.1  172652165-172652347 c
            1328-1459           JAXUCZ010000004.1  172643842-172643973 c
            1460-1568           JAXUCZ010000004.1  172616604-172616712 c
            1569-1716           JAXUCZ010000004.1  172609293-172609440 c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1716
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /note="solute carrier family 15, member 5"
                     /db_xref="GeneID:502918"
                     /db_xref="RGD:1564925"
     CDS             1..1716
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /codon_start=1
                     /product="solute carrier family 15 member 5"
                     /protein_id="NP_001178944.1"
                     /db_xref="GeneID:502918"
                     /db_xref="RGD:1564925"
                     /translation="MFVTGFIINDEKAPLPLHGGPERQKTVGHLGCFRVGICSLLVEL
                     CERFTFFEVVCNMIPFCTRRLGCYNHQAAILNLCFIGASVLTPVFMGWLSDSKYLGRN
                     KLVYIAVFLHFLGTALLSVLAFPSEDFYGGTSPASNMPMKKRAGLFHVALLTLCLGTG
                     GIRAVVCLPDACGHWEQESKKPMSFCNWASWSMNLNTAVVFLGVSSIQLLGSGAVMIL
                     LPSLSVFTASVTLYMTYCDLIYEPENHCSLPTVSRAFARVLKTRCLLYCHLGRAGSSW
                     LARAMAKQGVCHCELQEEETENVFSALLSLFSFQLIYRMCLTQIPSGYYLQTMHSNRT
                     LGGVPLPIALMNAISLLPLLTLGPFMDFFSNCLLPSKRDGPFLSVCIIAGNICAAFSV
                     AVAGFLEIHRKLAQEQSPSGKLSSVSSMACVYLVPQYVLLGVSEVLVNPAVSTVTRRV
                     VPSTFRRASMTCLTLFHGSAYFAGALLIELVYLISEGNWFPNTLNKGNLESFFFVLAS
                     LTLLNILGLWRVLPRCCNLNHFNAQRIHGNNCEETLLLSEKSLKFYGSTQETSSSIDL
                     RETAF"
     misc_feature    97..1569
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /note="Major Facilitator Superfamily; Region: MFS;
                     cl28910"
                     /db_xref="CDD:475125"
     misc_feature    97..1569
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /note="Major Facilitator Superfamily; Region: MFS;
                     cl28910"
                     /db_xref="CDD:475125"
     misc_feature    order(136..141,148..153,160..162,259..261,475..480,
                     484..492,499..501,568..570,577..582,589..591,928..930,
                     937..942,949..957,964..966,1057..1059,1069..1071,
                     1303..1308,1318..1320,1330..1332,1378..1380,1387..1392,
                     1399..1404,1411..1413)
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340907"
     misc_feature    order(136..141,148..153,160..162,259..261,475..480,
                     484..492,499..501,568..570,577..582,589..591,928..930,
                     937..942,949..957,964..966,1057..1059,1069..1071,
                     1303..1308,1318..1320,1330..1332,1378..1380,1387..1392,
                     1399..1404,1411..1413)
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340907"
     exon            1..343
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            344..563
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            564..733
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            734..957
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1144
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1327
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1459
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1568
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1716
                     /gene="Slc15a5"
                     /gene_synonym="RGD1564925"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttgtta caggcttcat cataaatgat gagaaagcac ccttaccctt acatggtggc
       61 cctgagcggc agaagacggt gggacatttg gggtgtttcc gagttggaat ctgctcgctt
      121 ctggtggagc tgtgtgaaag gttcactttc ttcgaagttg tctgcaacat gatccccttc
      181 tgcacaagga ggcttggctg ctacaaccac caggcagcca ttctcaactt gtgcttcatt
      241 ggagcctccg tccttacccc tgtgtttatg ggatggctct cggatagcaa gtacctcggg
      301 aggaacaaac tggtttacat agccgtgttt ctacatttcc taggcactgc cttgttatca
      361 gtgcttgctt ttccctcgga ggatttctac ggaggcactt ctcctgcgtc taacatgccc
      421 atgaagaagc gggccgggct gtttcatgta gcgctgctga ccctctgcct gggcacagga
      481 ggaataaggg ccgtcgtttg tctgccggat gcgtgtggcc attgggagca ggagtcaaag
      541 aagccaatgt cattttgtaa ctgggcctcg tggtccatga acctgaatac cgctgttgtc
      601 tttctgggag tctcaagcat ccagctcttg gggtctgggg ccgttatgat cctgcttcct
      661 tctctgtccg tgttcaccgc atcggtaact ctttacatga cgtactgcga cctgatctat
      721 gagccagaga accattgctc cctcccgacc gtctccaggg cgtttgctag ggtcctgaaa
      781 acacgctgcc tgctgtactg ccatcttggg cgagccggat caagttggtt agcccgtgcc
      841 atggcaaaac aaggtgtttg ccactgtgaa ctccaggagg aagagacaga aaatgtcttc
      901 tccgcccttt tgtctctctt cagcttccag ctcatataca gaatgtgcct tacgcagatt
      961 ccttcgggat attatcttca gaccatgcat tccaacagga ccttgggcgg agtccctctg
     1021 ccaattgcgc taatgaacgc catcagcctt ctgcccttat tgaccctggg tccatttatg
     1081 gatttcttca gcaactgtct acttccctct aagagagacg gaccgttctt gtcagtgtgc
     1141 attattgctg gtaacatttg tgcagccttc tctgtggcag tggccggctt cctagaaata
     1201 cacagaaaac ttgcccagga gcagtctcct tcaggcaaac tttcctctgt ttcctccatg
     1261 gcctgcgtct atctggttcc gcagtacgtg ctgcttggag tgtctgaggt cctggtaaac
     1321 ccagcggtct ccacggtgac acgcagagtc gttccaagca ccttcagaag agcttccatg
     1381 acgtgtctga ccctgttcca tggatccgcc tatttcgccg gggcactgct gatagagttg
     1441 gtttatctca tctcagaagg caattggttt ccaaacacat taaacaaagg caatttggag
     1501 agcttcttct tcgtgctggc atccttgacg ctgttgaaca tcctgggact ctggagggtt
     1561 ttgccgagat gttgtaatct aaatcatttt aatgcccagc gcatccatgg aaataattgt
     1621 gaagaaactc ttctcctctc tgaaaagtct ctcaagtttt atggcagtac acaggaaaca
     1681 tcttcgagta tcgatcttcg ggagacagcc ttctga
//
LOCUS       NM_001099510            2565 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 51 (Vom2r51), mRNA.
ACCESSION   NM_001099510 XM_578392 XR_007948
VERSION     NM_001099510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On or before Aug 17, 2007 this sequence version replaced
            XR_007948.1, XM_578392.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000004.1  158569940-158570154 c
            216-513             JAXUCZ010000004.1  158568504-158568801 c
            514-1323            JAXUCZ010000004.1  158554616-158555425 c
            1324-1548           JAXUCZ010000004.1  158540682-158540906 c
            1549-1672           JAXUCZ010000004.1  158539337-158539460 c
            1673-2565           JAXUCZ010000004.1  158520335-158521227 c
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2565
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="vomeronasal 2 receptor, 51"
                     /db_xref="GeneID:502891"
                     /db_xref="RGD:1561712"
     CDS             1..2565
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 51"
                     /protein_id="NP_001092980.1"
                     /db_xref="GeneID:502891"
                     /db_xref="RGD:1561712"
                     /translation="MKLLIAFSLLIVLIVFQEQISWFSLSIPASPGYYQDGDFVIGGL
                     FSLRVTAGDTKSKFGFKDTISMPDIVYADFTKHYQHMLAMVFAIENINKDPNILFNMS
                     LGFYLFNVDFIEMKAVESSMALLSGETPPVPNYSCRPEKTDKLVAVIGGISTGISTQI
                     SRVLSLYNVPQISYAPFDQSLGTEVQLQSPYQFPVHTTALYQGIIQLLLYFTWIWVGL
                     VVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPARDTINRKLFMERFILTRVIVA
                     FGDTYSLLRFVYNIYCNTPFGNIWITTSDWDITTLPFQQNLGYTYFGGGLSFSVHTDE
                     ILEFKDFLRSVQPRKYPQDIFIQDVWSNLFECPYLDKDWIRELSQCEQNGNLSTRPLY
                     LWDMNTSPSSYKVHFAVYAIAEALHEELSLTVEGDSLRKGGPRALLPWKLHPFLQKCQ
                     LGRSSNEQNVMNNEVSATKLDIFNYQSLQSGTKAQVKVGKFVYESHSVQHFSLNDKII
                     MWGEHHNHTPFSVCSQSCPLGFRKSPIEGKPFCCFDCLPCPDGEIANETDMDQCIKCP
                     EDQYPNKQRNWCHPKITAFLSHEDTLGAVLVSVAISLSVFSAMILGLFICYRDTPIVR
                     ANNRNLSYLLLVSLMLCFFCSLIFIGQPRTVTCVLRQTIFGVVFSIAISAILAKTFIV
                     VVAFKAIKPGSTLQTWMVTRVSNAIVCCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQ
                     IILWCNEGSTLAFYCVLGYLGFLASLSLLIAFLARRLPDTFNEAKTITFSMLVFCSVW
                     ISFVPAYLSSKGKTMVAVEILTILASSAGLLGCIFLPKCFVILLKSGGLPRKKFSI"
     misc_feature    118..1530
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1530
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(226..228,523..528,1201..1203)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(226..228,523..528,1201..1203)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,484..486,745..747)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,484..486,745..747)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1552..1713
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1552..1713
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1771..2526
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1771..2526
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1771..1848
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1771..1848
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1780..1782,1789..1794,1801..1806,1810..1815,
                     1915..1917,1927..1929,1936..1941,1963..1965,1975..1977)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1780..1782,1789..1794,1801..1806,1810..1815,
                     1915..1917,1927..1929,1936..1941,1963..1965,1975..1977)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1882..1947
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1882..1947
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1942..1944,1978..1983,1990..1995,2002..2004,
                     2242..2244,2257..2259,2266..2271,2278..2280,2380..2382,
                     2389..2394,2401..2403,2413..2415,2437..2442,2449..2451,
                     2458..2460,2470..2472)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1942..1944,1978..1983,1990..1995,2002..2004,
                     2242..2244,2257..2259,2266..2271,2278..2280,2380..2382,
                     2389..2394,2401..2403,2413..2415,2437..2442,2449..2451,
                     2458..2460,2470..2472)
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1972..2046
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1972..2046
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2116..2166
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2116..2166
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2245..2325
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2245..2325
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2347..2418
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2347..2418
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2431..2508
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2431..2508
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..215
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
     exon            216..513
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1323
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1548
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1672
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..2565
                     /gene="Vom2r51"
                     /gene_synonym="RGD1561712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaattgc tcattgcttt ctctctcctg attgttctca ttgtattcca ggaacaaatt
       61 tcttggtttt ccttaagtat acctgcctct cctggctact atcaagatgg ggattttgtt
      121 attggaggac tcttttccct tagagtgact gctggagaca ctaaaagtaa atttggcttt
      181 aaagatacaa tctctatgcc tgatattgtt tatgcggatt tcaccaaaca ttatcagcac
      241 atgttggcaa tggtttttgc tatagaaaat atcaacaagg atccaaatat tttattcaat
      301 atgtccctgg gattctatct cttcaatgtt gactttattg agatgaaggc tgtggagagt
      361 tctatggctt tgctctcagg agagaccccc ccagttccta actacagctg caggcctgag
      421 aagactgata agctggttgc agtgatagga ggcatttcaa caggaatatc aacccagatc
      481 tcccgagttc taagtctcta caatgtccct cagatcagct atgctccttt tgaccagagt
      541 cttgggaccg aagtccagct ccagtctcct taccagtttc ctgtgcatac cacagctctg
      601 tatcagggaa ttattcaact gctgctatac ttcacttgga tctgggttgg cctggtggtt
      661 ccagatgatg tgaggggaga actcttcctt agggacatca cagaggagat gaacaaccat
      721 ggactttgtg ttgcatttgc agaaaaggtt ccagaattcc ctgctaggga cacaataaac
      781 aggaaacttt ttatggaaag attcatattg acccgtgtta ttgttgcatt tggtgacaca
      841 tattctcttc tgagatttgt ctacaacatc tattgtaata ccccttttgg taacatctgg
      901 atcacaactt ctgattggga tatcaccaca ttaccctttc aacaaaatct aggttatacc
      961 tattttggtg gaggattatc attttctgtt cacacggatg aaattctgga attcaaggat
     1021 tttctcagaa gtgttcaacc taggaaatac cctcaagata tctttatcca ggatgtgtgg
     1081 tcgaacttat ttgaatgtcc ttatttagat aaggactgga tcagggaact gagtcaatgc
     1141 gagcaaaatg gcaacctcag cacccgacct ttatatcttt gggacatgaa tacttcaccc
     1201 tcaagctaca aagtccattt tgctgtatat gccattgccg aggcccttca tgaggagctg
     1261 tcactcaccg tggaaggaga ctcactcagg aaaggtggtc cccgagctct tctcccatgg
     1321 aagctccatc cattcttaca aaagtgccaa cttgggagaa gctccaatga gcagaatgtc
     1381 atgaacaatg aggtttcggc aaccaagctt gacatcttta attaccagtc tctgcagagt
     1441 ggtaccaaag ctcaagtgaa agttggcaag tttgtatatg aatctcacag tgttcaacat
     1501 ttttccctaa atgacaaaat cataatgtgg ggtgaacacc acaatcatac gcctttttct
     1561 gtttgcagtc aaagttgtcc acttggattt aggaaatcac ctattgaagg gaaaccattc
     1621 tgttgttttg attgtcttcc atgtccagat ggagagattg caaatgaaac agatatggat
     1681 caatgcatca agtgtcctga agatcaatat cccaataagc agaggaattg gtgtcacccc
     1741 aaaattacag catttttgtc ccatgaagat actctaggag cagttttggt ttccgtggca
     1801 attagtttat ctgtcttttc agccatgatt ttaggattat ttatctgcta tcgggacaca
     1861 cccattgtca gagcaaataa cagaaatctc agttatctcc tcctggtttc tctaatgctc
     1921 tgcttctttt gctcattaat attcattggc caacctagaa cagtcacttg tgtcttgaga
     1981 caaacaattt ttggggttgt attttccatt gccatttctg ctatcttggc aaagaccttc
     2041 attgtggttg tggccttcaa ggccatcaaa cctggaagca ctttacaaac atggatggtg
     2101 acccgagtct caaatgctat agtctgctgt ggttccatca ttcaagtgtg catctgcgcc
     2161 gtctggctgg gaacgtatcc ccctttccct gatgtcgaca tgcactcaga gtttgggcaa
     2221 atcatcctct ggtgtaatga gggctccacc cttgccttct attgtgttct ggggtacttg
     2281 ggctttctgg ccagtctcag cttgcttatt gcttttcttg ctagaaggct accagacacc
     2341 ttcaatgagg caaaaacaat cacattcagc atgctggttt tctgcagtgt gtggatttct
     2401 tttgtacctg cttacctgag ctccaaaggc aaaaccatgg ttgctgtgga aattctcaca
     2461 attctggctt ccagtgctgg cttactgggc tgtatatttc ttcccaaatg ctttgtgatc
     2521 ctactgaaat caggtggcct tccaagaaag aagttctcta tatga
//
LOCUS       NM_001191956            1035 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus calcium homeostasis modulator 3 (Calhm3), mRNA.
ACCESSION   NM_001191956 XM_574682
VERSION     NM_001191956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Ma,Z., Taruno,A., Ohmoto,M., Jyotaki,M., Lim,J.C., Miyazaki,H.,
            Niisato,N., Marunaka,Y., Lee,R.J., Hoff,H., Payne,R., Demuro,A.,
            Parker,I., Mitchell,C.H., Henao-Mejia,J., Tanis,J.E., Matsumoto,I.,
            Tordoff,M.G. and Foskett,J.K.
  TITLE     CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic
            Neurotransmission of GPCR-Mediated Tastes
  JOURNAL   Neuron 98 (3), 547-561 (2018)
   PUBMED   29681531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_574682.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1811448.1,
                                           SRR26360181.1839856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               JAXUCZ010000001.1  255989308-255989594 c
            288-543             JAXUCZ010000001.1  255987370-255987625 c
            544-1035            JAXUCZ010000001.1  255984593-255985084 c
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1035
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /note="calcium homeostasis modulator 3"
                     /db_xref="GeneID:499368"
                     /db_xref="RGD:1560215"
     CDS             1..1035
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /note="family with sequence similarity 26, member A"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 3"
                     /protein_id="NP_001178885.1"
                     /db_xref="GeneID:499368"
                     /db_xref="RGD:1560215"
                     /translation="MDRFRMLFQNFQSSSESVTNGICLLLAAVTVKMYSSLDFNCPCL
                     EHYNALYGLGLLLTPPLALFLCGLLVNRQSVLMVEEWRRPAGHRRKDLGIIRYMCSSV
                     LQRALAAPLVWILLALLDGKCLVCAFSNSVDPEKFLDFANMTPSQVQLFLAKVPCKED
                     ELVKTSPARKAVSRYLRCLSQAIGWSITLLVIVVAFLARCLRPCFNQTVFLQRRYWSN
                     YMDLEQKLFDETCCEHARDFAHRCVLHFFASMQSELRALGLHRDPAGEILESQEPPEP
                     PEEPGSESGKAHLRAISSREQVNHLLSTWYSSKPPLDLAASPRLWEPGLNHRAPIAAP
                     GTKLGHQLDV"
     misc_feature    4..756
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /note="Calcium homeostasis modulator; Region: Ca_hom_mod;
                     pfam14798"
                     /db_xref="CDD:464320"
     misc_feature    4..756
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /note="Calcium homeostasis modulator; Region: Ca_hom_mod;
                     pfam14798"
                     /db_xref="CDD:464320"
     exon            1..287
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /inference="alignment:Splign:2.1.0"
     exon            288..543
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1035
                     /gene="Calhm3"
                     /gene_synonym="Fam26a; RGD1560215"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacaggt tccgaatgct cttccagaac ttccagtcca gctcggagtc ggtgacgaac
       61 ggcatctgcc tcctgctggc tgctgtcacc gtcaagatgt actcctccct cgacttcaac
      121 tgtccctgcc tagagcacta caatgccctc tatggcctgg gcctgctgct cacaccccct
      181 ctggccctct tcctctgtgg tctcttggtc aatagacagt ctgtgttgat ggtggaggag
      241 tggcgccggc cagcagggca ccggaggaag gacctaggca tcatcaggta catgtgctcc
      301 tctgtgctgc agcgagctct agcagcacct ctggtctgga tcttactggc cctccttgat
      361 gggaagtgtc ttgtgtgtgc cttcagcaac tccgttgacc ctgagaagtt tctggatttt
      421 gctaatatga cccccagcca ggtgcagctc ttcctagcca aggtgccctg caaggaagat
      481 gagctggtta aaaccagccc agctcgcaag gctgtgtctc ggtacctccg gtgcctgtca
      541 caggccatcg gctggagtat aaccttgctg gtgatagtgg tggccttcct agcccgctgt
      601 ctgaggccct gcttcaacca gacggtcttc ctacagcgca gatactggag caactatatg
      661 gacctggaac agaagctctt tgatgagaca tgctgtgagc atgcgcggga cttcgcacat
      721 cgctgcgtgc tgcacttctt cgcaagcatg cagagcgagc tacgcgctct ggggttacat
      781 cgggacccag ctggcgagat cctagagtca caggaacccc cggagccccc ggaggagccg
      841 ggtagtgaaa gcgggaaggc ccacctgcgt gcaatctcca gccgagagca agtgaatcac
      901 ctcctaagta cctggtactc cagcaagcca ccgcttgacc tcgcagcctc cccaaggctc
      961 tgggagcctg gcctcaatca tcgtgcccct atagctgctc caggcaccaa gctgggccac
     1021 cagcttgatg tatag
//
LOCUS       NM_001099655            2550 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 16 (Vom2r16), mRNA.
ACCESSION   NM_001099655 XR_006928
VERSION     NM_001099655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2550)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 26, 2007 this sequence version replaced XR_006928.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  71910164-71910360
            198-489             JAXUCZ010000001.1  71912765-71913056
            490-1302            JAXUCZ010000001.1  71914539-71915351
            1303-1530           JAXUCZ010000001.1  71921020-71921247
            1531-1654           JAXUCZ010000001.1  71924759-71924882
            1655-2550           JAXUCZ010000001.1  71927399-71928294
FEATURES             Location/Qualifiers
     source          1..2550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2550
                     /gene="Vom2r16"
                     /note="vomeronasal 2 receptor, 16"
                     /db_xref="GeneID:690691"
                     /db_xref="RGD:1593384"
     CDS             1..2550
                     /gene="Vom2r16"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 16"
                     /protein_id="NP_001093125.1"
                     /db_xref="GeneID:690691"
                     /db_xref="RGD:1593384"
                     /translation="MHTLILFFLLLNIPLLVVSLIHPRCFWRMKQNEEKNGNLKTGCI
                     FAFGVVKWPVEKEYYYNILSTQTNTENHQFSLALAFSMDEINKNPDLLPNKSLLFDFP
                     FYSCKSHSELTTLIHGSVQQYDIFPNYVCNNETMCTLLLTGPNWKISVILRTYLDLYK
                     SQQFLQLTYGPFHPVLSDNEQFPYLYQMAPKETSLALALVSFLIHFSWNWIGLAISDN
                     DQGNQFLSYLRTEMGKYTVCFAFVNMIPVNMQLFMTRTDVYYNQIITSSTNVVIVYGD
                     TDSTLALGFKMWKSLGVQRIWVTTSEWDVITSKRDFTFDTFHSIIAFQHHHGEISGFK
                     NFVQTLNPFKYSDKYLVKLEWMYFNCEISASNCKTLKNCLYNESFEWLSEQTFDMAFS
                     DGTHDIYNAAYAVAHALHEFFLQQGDNQQKYRGKWPNSVCLKLHSLLKKTHFTNPVGD
                     RVIMNQREKMQEEYDIFYIWNFPQGLGLKVKIGEFSPYYSSGKQLWLFEDMIEWTTGN
                     RQMPSSVCNSDCGPGFRKIWKEGMSTCCFDCIHCQENEISNETNVDQCVKCPEDQYAN
                     PEQNHCIHKALIFLTYQETLGMTLSLVALCLSTLTAAILGVFVKYHTTPIVKANNCRL
                     TYILLITLIFCFLCPLLYIGHPNSVTCVLQQVTFGIVFTVAISTVLAKTITVILAFKV
                     TAPQRMIKYFLISGVFNYIIPICTLIQVFVCTLWLGTSPPSVDFDPQSEHGHIIIVCN
                     KGSVTAFYCMLGYLSCLALGSFTLAFLSRNLPGTFNEAKFLTFSMLVFCSVWITFLPV
                     YHSTKGKVMVAVEIFSTLASSAGMLGCIFIPKCYIILLRPERNSLQRIREK"
     misc_feature    121..1512
                     /gene="Vom2r16"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1512
                     /gene="Vom2r16"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r16"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r16"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1695
                     /gene="Vom2r16"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1695
                     /gene="Vom2r16"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1753..2508
                     /gene="Vom2r16"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..2508
                     /gene="Vom2r16"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r16"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r16"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r16"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r16"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
     exon            198..489
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1302
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1654
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2550
                     /gene="Vom2r16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcacactc taattttatt cttcttgctt ttgaatattc cactccttgt ggtcagtttg
       61 attcatccca ggtgcttttg gagaatgaag cagaatgaag agaagaatgg aaacctgaaa
      121 acaggttgta tctttgcatt tggagttgtg aaatggccgg tggagaaaga gtactactac
      181 aatattctca gtacacaaac aaatactgaa aatcaccagt tttctctggc cttggctttt
      241 tccatggatg aaatcaacaa gaaccctgat cttttaccaa ataagtcttt actatttgac
      301 ttcccatttt acagttgtaa aagtcactca gaattaacca cactcattca tgggtctgta
      361 caacaatacg atatttttcc taattatgtt tgtaacaatg agaccatgtg tacattgttg
      421 ctaacaggac caaattggaa aatatctgtg atacttcgga catacctgga cctttacaaa
      481 tcccagcagt tccttcagct tacttatgga cctttccatc ctgtcctgag tgacaatgaa
      541 caatttcctt atctgtatca gatggcccct aaggaaacat ctcttgcctt ggccctggtc
      601 tccttcctaa ttcatttcag ttggaactgg attgggctgg ccatctcaga caatgatcag
      661 ggtaatcaat tcctatcata tttgagaaca gagatgggaa aatatacagt ctgctttgcc
      721 tttgtgaaca tgatccctgt caacatgcaa ttattcatga caagaactga tgtgtattac
      781 aaccaaatca tcacatcatc cacaaatgtt gttattgttt atggtgacac agatagtact
      841 cttgctttgg gctttaaaat gtggaaatct ctaggtgtac agagaatatg ggttaccact
      901 tcagagtggg atgtcattac tagtaagaga gacttcacat ttgacacttt ccatagcatt
      961 attgcttttc aacaccacca tggtgagatt tctggtttta aaaattttgt gcagacattg
     1021 aaccctttca aatactcaga taaatatctc gtaaagttag agtggatgta ctttaactgt
     1081 gaaatttcag catctaactg taagacactg aagaactgct tatacaatga gtcatttgaa
     1141 tggctaagtg aacagacttt tgacatggcg tttagtgatg gcactcatga catatacaat
     1201 gctgcatatg ctgtggccca tgccctccat gagttctttc ttcaacaagg agataatcag
     1261 cagaagtaca gagggaaatg gcccaattct gtgtgcttga agttacattc tttgctaaag
     1321 aagacccact tcactaatcc tgttggggac agagtaatta tgaaccagag agaaaaaatg
     1381 caggaagagt atgacatttt ctacatttgg aattttccac aaggtcttgg acttaaggta
     1441 aagataggag agtttagtcc atattattca agtgggaaac agctctggtt atttgaagat
     1501 atgatagagt ggaccacagg aaatagacag atgccatctt ctgtgtgcaa tagtgattgt
     1561 ggtcctgggt tcagaaaaat ctggaaggag ggaatgtcaa cctgctgttt tgattgcata
     1621 cactgccaag aaaatgaaat ttctaatgag acaaatgtgg atcaatgtgt caagtgtcct
     1681 gaggaccagt atgctaaccc agagcagaat cactgcattc ataaagctct tatttttctg
     1741 acctatcaag aaaccttggg gatgactctt tccttagtgg ccttatgcct ctctactctc
     1801 acagctgcca ttcttggcgt ctttgtgaag taccatacga ctcccattgt taaggccaat
     1861 aactgcagac tcacctatat cttgctcatc accctcattt tttgtttcct ctgccccttg
     1921 ctttacattg gccatccaaa ctcagtcacc tgtgtcctgc agcaagtcac atttggaatt
     1981 gtattcactg tggctatttc cactgtattg gcaaaaacaa ttactgtcat tcttgccttc
     2041 aaagttacag cccctcaaag aatgataaaa tattttctta tttcaggagt atttaactat
     2101 atcattccca tctgtactct catccaagtt tttgtctgta cactctggct gggaacttct
     2161 cctccttctg tagattttga tccacagtct gagcatggcc acatcattat tgtttgcaac
     2221 aagggttcag tcactgcctt ttactgtatg ttgggttacc tgtcctgcct agcccttggg
     2281 agtttcactc ttgctttctt gtccaggaac ctgcctggca cattcaatga agccaagttt
     2341 ctgacattca gcatgctggt attctgcagt gtctggatca ctttcctccc tgtctaccat
     2401 agcactaagg gaaaggtcat ggtggcagtg gagatttttt ccacattagc ttccagtgca
     2461 gggatgctcg gatgtatttt tattcctaag tgctacataa ttttgttaag accagagaga
     2521 aattctctac aaaggatcag ggagaaataa
//
LOCUS       NM_001394994            3521 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus SEH1-like nucleoporin (Seh1l), transcript variant
            1, mRNA.
ACCESSION   NM_001394994
VERSION     NM_001394994.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3521)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   5  (bases 1 to 3521)
  AUTHORS   Ahn,S.H., Deshmukh,H., Johnson,N., Cowell,L.G., Rude,T.H.,
            Scott,W.K., Nelson,C.L., Zaas,A.K., Marchuk,D.A., Keum,S.,
            Lamlertthon,S., Sharma-Kuinkel,B.K., Sempowski,G.D. and Fowler,V.G.
            Jr.
  TITLE     Two genes on A/J chromosome 18 are associated with susceptibility
            to Staphylococcus aureus infection by combined microarray and QTL
            analyses
  JOURNAL   PLoS Pathog 6 (9), e1001088 (2010)
   PUBMED   20824097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3521)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   7  (bases 1 to 3521)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   8  (bases 1 to 3521)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.252759.1,
                                           SRR26360190.1746549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000018.1  63616875-63617115
            242-292             JAXUCZ010000018.1  63621318-63621368
            293-439             JAXUCZ010000018.1  63624767-63624913
            440-651             JAXUCZ010000018.1  63626014-63626225
            652-750             JAXUCZ010000018.1  63628455-63628553
            751-891             JAXUCZ010000018.1  63632848-63632988
            892-1049            JAXUCZ010000018.1  63633520-63633677
            1050-1200           JAXUCZ010000018.1  63636252-63636402
            1201-3521           JAXUCZ010000018.1  63637532-63639852
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3521
                     /gene="Seh1l"
                     /note="SEH1-like nucleoporin"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
     exon            1..241
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1213
                     /gene="Seh1l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleoporin SEH1; nucleoporin SEH1-like"
                     /codon_start=1
                     /product="nucleoporin SEH1 isoform 1"
                     /protein_id="NP_001381923.1"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
                     /translation="MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSES
                     GDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSH
                     WVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRVYEAPDVMNLSQWSLQHEIS
                     CKLCCSCISWNPSSSRAHPPMIAVGSDDSSPNSMAKVQIFEYNENTRKYAKAETLMTV
                     TDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDN
                     HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQLGN
                     STPSLSSNIPNLQNSLNGTSAGRKHS"
     misc_feature    <161..1114
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <161..1114
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    173..295
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    173..295
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    311..463
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    311..463
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    476..577
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    476..577
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    626..766
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    626..766
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    794..931
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    794..931
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    971..1090
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    971..1090
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            242..292
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            293..439
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            440..651
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            652..750
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            751..891
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1049
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1200
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..3521
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgtggc gcgccggagc gacgcgagca ggcgagggcc gacgtaccgt acgtgcctct
       61 gccgcggtcc gggggctgcg ggccgcaccg ccgccctctc ggaggcgggc ccgggcagac
      121 ggcggcggcc atgtttgtgg cgcgcagcat cgcggcggac cacaaggacc tcatccacga
      181 tgtgtctttc gacttccacg ggcgccggat ggccacctgt tccagcgacc agagcgtcaa
      241 ggtgtgggat aagagcgaga gcggagattg gcactgcaca gctagttgga agacacatag
      301 tggatctgta tggcgtgtga catgggctca tcctgagttt ggacaagttt tggcttcctg
      361 ttcttttgac cgaacagcag ccgtatggga agaaatagta ggagagtcaa acgataaact
      421 tcgaggacag agtcactggg tgaaaaggac aactctagtg gacagcagaa catctgttac
      481 agatgtgaaa tttgctccca agcacatggg tctgatgtta gcaacctgct ctgcagatgg
      541 catcgtgaga gtctacgagg ccccagatgt gatgaacctc agccagtggt ccctgcagca
      601 cgagatctcg tgtaagctgt gctgcagctg catttcttgg aacccttcca gctctcgtgc
      661 tcaccccccc atgatcgctg tgggaagtga tgacagcagt ccaaattcaa tggccaaggt
      721 tcagatcttt gagtacaatg aaaacaccag gaaatatgca aaagctgaga ctcttatgac
      781 agtcacggat cctgtccatg acattgcgtt tgctccaaat ttgggacgat ctttccacat
      841 cctggcaata gcaaccaaag atgtaagaat tttcacatta aaacctgtga ggaaagaact
      901 tacttcttct ggtggtccaa caaaatttga aatccatatt gtggctcagt ttgataatca
      961 taattctcag gtctggaggg tgagttggaa cataacagga acagtattgg cgtcttcagg
     1021 agatgacggc tgtgttaggt tgtggaaagc taattacatg gacaattgga agtgcactgg
     1081 tattttgaaa ggtaacggga gcccagtaaa tgggagttct cagctgggaa actcaactcc
     1141 ttcactgagc tcaaatattc caaatcttca aaattcatta aatggaacat ctgctggcag
     1201 aaagcacagc tgagtgcacg ctagctggag tgactgtgct gctgtgctgc ttgttgcatg
     1261 cacacaggaa tggaaaccaa cttctttccc tccccagcgc cgtgtgatct ccacgatgca
     1321 ccagcagcct gttcactact acacacaggc ccaaaggcct ttaaatgaca gtgtatataa
     1381 cttctgtact agtcagactc ctgacactat aaatggaaag gctttttgtt gacatatcat
     1441 caccaaaaca attttttgga atgttctgga gactaacttg ggtttaaaaa ctgaaaagat
     1501 tgctattatc ctcataagca gttgggagga gggcaaatat aattttattc catttggaaa
     1561 atataggaat atgtctttta ttttctaaaa caataagcta aaatgatgag tttttataat
     1621 tttaatttga aaaatcaaat aaatattttc ataaagattg ttttgagtgg taatgtgttt
     1681 accttttgta gaattgctct gtaggtgaca ttatccacac aactacttta caggtgacat
     1741 tatccacaca actacatctc ttgtaattaa aatactagta caggaacaga tcagtaacgt
     1801 ggcaccagtt gagctcaaat agtttgtagc caagcagcac attagcaatt gctggtttta
     1861 ttggtagtaa aatggtgaca gcacttctaa gttttcatct catattcagg agatggctgt
     1921 ttctaatcta tgcatgaatg tttatggtgt gatcctatac aacttggttt cctttaagac
     1981 aatttggaaa catgagttga catttttcag aaaatgtgcg tgcagttaaa attccgtgtc
     2041 tcaggatttt taatgtgtta tttcaaagag tccctgtatt ctgaaacttt tgactttgat
     2101 gatagttata caccttttca cttactaaac tgcatacata ttacgggtaa gttatgagat
     2161 ggtagaataa caggctataa ttctttgagc ctttttatgc accaaaattc tgtaggtatt
     2221 ctaagttttt tgcaggaaac gaagcctgtg caatgattgt atttctcaag catgtggagt
     2281 gcagtagcca ggtctcccgg tagtgagttg gagctggttc tcggtatcat gtatgcacta
     2341 acgtgtgcct gctgctgtaa cacatgcagc tctgctggaa aggaagagca gatgtgtgaa
     2401 ttaaggaatc aaatgagatt agacacgctt tcagtttata aaatgaatgt ctctgtaaca
     2461 tacgtcctga tgattttggg ggcattttaa ctttaacaga ttgtattttt ttttaaaatt
     2521 tttatacttc ttaagcagcc ttgattcaag tgagagtctt gatttgtact gttctatcgg
     2581 ttgtggcatg aatatacagc tttttttcct tccttccagc atgttttctc ttctttggtt
     2641 ctctttgtat ttactgcttt tctctttttc ttctgtttcc ctccctcctt tccccctgtt
     2701 gtttttgttt tggtgttttg ttcctgtctt cattatttca ggtatttctt tccccctctg
     2761 gattccccac gggctggatc aagatggtcc agctgtgccc agctccttcc tcctcctgct
     2821 cctctgctag agcactcttg tgatgcagac actgccaacc tccactatcc tcaccctcgc
     2881 agaggatgcc tctctcggcc tcttaatccc ttacctgaga atgaaggggt gtaaaatcct
     2941 gatttaaagg ccttacccag atgcttgtaa atgcttttat tccgggctgc ttttggtttc
     3001 ttcattttct tttagaagat ccttcctagt taggccatgt cttgcatgta tcacaactcg
     3061 agtgtttgaa accaaacctg tttgtacttc tgcaccagga aaccttggct tcactagttg
     3121 gttaccttgg acgagatgag cttcagaaaa agcaatatta actgtgaacg attcccagta
     3181 tctggttcaa agtgcctgtc ttgtacattc attctgtgtg gacttgttat catagagttc
     3241 agttttgtct gttgatggta gcttcagagg aaagcatatc attgtgaact tcactctgta
     3301 attcagacat taagaaatgt ttggaatttt ataggctgat gttacaaatg actgtaaaat
     3361 aaatcattcc tgtgtataaa gcagcaaatc ataaggatat ttttgtcttt tttttttttt
     3421 tttaaaggaa aatgcctttt actacttgga attactactt aaaaattttg taactgttct
     3481 ccaagtaggt tatttaataa aagtatttta aaagatgtga a
//
LOCUS       NM_001134607            2586 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus KIAA1328 homolog (Kiaa1328), transcript variant
            1, mRNA.
ACCESSION   NM_001134607 XM_574112
VERSION     NM_001134607.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473974.1.
            
            On Sep 4, 2008 this sequence version replaced XM_574112.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132262, SAMD00132264
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2586
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="KIAA1328 homolog"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
     exon            1..34
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            35..177
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1686
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein hinderin isoform 1"
                     /protein_id="NP_001128079.1"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
                     /translation="MESLKGAGDSVAEQSFCKRGLKSASLKDLCVEDKRRIANLIKEL
                     ARVSEEKEVTEERLKTEQESFEKKIRQLEEQNELIIKEREDILLKYRECQELLSLYQK
                     YLSEQQEKLTMSLSELGAARAQEQQITKKKITHQSSLVNLDGSYLSVAKPQTCQTRAR
                     PKSENQDSASESHTALRNNSLKPVTLHHPKQDLERMSTETRTCTYESPGRRLINAAPV
                     EEALPEELKIKDYPNLLPTPSSQYCGHKYSESEAYVHENYHPTNMASQCCKTHPESCS
                     HCRMSWASLMHDGVTLQPRETDIEKQLSEDRRQQLMLQKMELEIEKERLQQLLAQQET
                     KLLLKQQQLHQSRLDYNCLLKPKCDGWLRGTSSSFRKCPDSPNSAQNQKEKKTVEFQS
                     HVENGIQWTCQQNDTCRLQRETATGVRKDASTSPMSTQSPKHPLTPASSSSKHKTSRY
                     ETSLLDLVQSLSPNSAPKCQPHSSRAAGTWSALRPTPKTSTWKKVGTHKSPEDLEENQ
                     ILEDIFFI"
     misc_feature    217..1188
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     misc_feature    217..1188
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     exon            178..272
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            273..402
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            403..516
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1190
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1372
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1481
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..2586
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgatgaag aacaatccgt agtttatgtt ccaggaatct ccacagaaag aaatacaaga
       61 tcaaggctca agttgataaa tccaaaagtt gatgctaaag ttaaggttcc caaggtgact
      121 gatattcctg cctccatgga gtctttaaaa ggtgcaggag attcagtagc tgaacagagt
      181 ttctgcaaga gaggactgaa gagtgcgtca ttgaaagatt tatgtgttga ggacaaaagg
      241 cgcattgcca atttaattaa agaactggcc agagtaagtg aagaaaagga ggtgacagag
      301 gagcgactga aaactgagca ggagtccttt gagaagaaga tccggcagtt ggaggaacag
      361 aatgaactga tcatcaaaga aagggaagat atccttttga aatatagaga atgtcaagaa
      421 cttctaagtc tctaccagaa gtacctgtca gagcagcaag agaagcttac catgtcgctc
      481 tcagagcttg gagctgctag agcacaggaa cagcagataa ccaagaagaa aatcactcac
      541 cagtcttcat tggtgaacct ggatggttcc tatctgagtg tagccaaacc gcaaacctgc
      601 cagaccaggg ccaggcctaa gtcagaaaac caggactcag cttcagaatc ccacacagca
      661 ttaaggaata attctttgaa accagtaaca cttcatcatc ccaaacagga tttagagagg
      721 atgtcaacag aaaccagaac gtgtacttat gaatctccag ggaggagact aataaatgca
      781 gccccagtag aggaagctct cccagaagag ttgaagataa aggactatcc aaaccttctg
      841 cctactccat ctagtcagta ctgtggtcat aaatactctg aaagtgaagc ttatgttcat
      901 gagaactatc atcctacgaa catggcctct cagtgttgta agacacatcc agaatcatgc
      961 agtcattgta ggatgtcctg ggcatctctc atgcatgatg gagtgacact gcaacccaga
     1021 gaaaccgaca tcgaaaaaca actctcagaa gatcgaaggc agcagctgat gcttcagaaa
     1081 atggaactgg aaattgaaaa ggaacgcctt cagcaactcc tggcccaaca agagacaaag
     1141 cttctcctta aacagcagca gctgcaccaa tcccgactag attacaattg tttattgaag
     1201 ccgaaatgtg atggatggct gcgtggaacc tcatcgtcct tcagaaagtg cccagactct
     1261 ccaaacagtg cgcaaaacca gaaggagaag aaaactgttg agtttcagtc acacgtggag
     1321 aatggcattc aatggacatg tcaacagaat gacacatgca gactccagag agagacagca
     1381 actggagtta gaaaagatgc ttccacatct cctatgtcaa cacaaagccc taaacacccc
     1441 ctgacaccag cctcatcgtc atccaagcac aaaacctcaa ggtatgagac atctctgttg
     1501 gacttggttc agtctctgag cccaaattct gctcctaaat gtcagcccca ttcctccaga
     1561 gcagcaggga catggagtgc tctccgacct acccctaaga catctacctg gaagaaagtg
     1621 gggacacata agagccctga ggacctggag gagaatcaga ttctggaaga catatttttc
     1681 atatgactct gaagcacatg ctacagaatt tccacaggaa atatttgagt ttctttccat
     1741 attgatgtag gatgttaaac tgaaaagaag ccgtgtctct cctttcgtgg agacctcttg
     1801 ctggcatcct tttatagtat tgaatataga aagcattctt ataaatcagg gtggtttttg
     1861 tcagaccagt tagcagaaac agactaaagg gggtcactta gaggtaggat cttttctata
     1921 ccaaacagaa attagaaatt gtggatactg cctgcatagt aaaacccatg aatgtctagt
     1981 gtcattttaa gagtgttttc aatttactac tgcaaaaagt tgactcttta cagatggaaa
     2041 acgttcccat tgacagaccc cttaaatatg aaagtagcca cttcagaaag gctcttctct
     2101 cctcaccaat gctaagtgtg gcgcttcatt ccgacgttga agttggtgac tctaatatca
     2161 tcttacatgg gaccaatact tgtgggtcat agtggtcaac cgagtcattg ccacccctta
     2221 aaccaaaagg ctgaatgact tagagggaag tttgcaacca gacagtggca ttagaccaca
     2281 tgagggcatg gccgcctggg gaaatttacc agtgtccagg cagccacctc tccagtgttc
     2341 catgatgggt gtttcttgtc gacttcagtg ttgtaaactt tacctgtggt tgtgtctgag
     2401 gaagatagca ctagaggaag agtggtgtcg agtggctgca ggctggcagg ttccttctgc
     2461 cccacctcac accataggac gagtatcctc ctctgagcac cgtggatgca gagtctgaga
     2521 acgctctgct gattaccctt cttggcccag atctagatct tttctcctca ggctgagctc
     2581 agtgct
//
LOCUS       NM_012755               1845 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase
            (Fyn), mRNA.
ACCESSION   NM_012755 XM_001062721
VERSION     NM_012755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Li,H., Zhou,X., Chen,R., Xiao,Y. and Zhou,T.
  TITLE     The Src-Kinase Fyn is Required for Cocaine-Associated Memory
            Through Regulation of Tau
  JOURNAL   Front Pharmacol 13, 769827 (2022)
   PUBMED   35185557
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Zhang,L., Wang,L., Xiao,H., Gan,H., Chen,H., Zheng,S., Jian,D.,
            Zhai,X., Jiang,N., Jing,Z. and Liang,P.
  TITLE     Tyrosine kinase Fyn promotes apoptosis after intracerebral
            hemorrhage in rats by activating Drp1 signaling
  JOURNAL   J Mol Med (Berl) 99 (3), 359-371 (2021)
   PUBMED   33409551
  REMARK    GeneRIF: Tyrosine kinase Fyn promotes apoptosis after intracerebral
            hemorrhage in rats by activating Drp1 signaling.
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Luo,X., Li,Z., Zhao,J., Deng,Y., Zhong,Y. and Zhang,M.
  TITLE     Fyn gene silencing reduces oligodendrocytes apoptosis through
            inhibiting ERK1/2 phosphorylation in epilepsy
  JOURNAL   Artif Cells Nanomed Biotechnol 48 (1), 298-304 (2020)
   PUBMED   31852295
  REMARK    GeneRIF: Fyn gene silencing reduced the apoptosis of OLs through
            inhibiting the phosphorylation of ERK1/2 in epileptic model
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Egervari,G., Akpoyibo,D., Rahman,T., Fullard,J.F., Callens,J.E.,
            Landry,J.A., Ly,A., Zhou,X., Warren,N., Hauberg,M.E., Hoffman,G.,
            Ellis,R., Ferland,J.N., Miller,M.L., Keller,E., Zhang,B.,
            Roussos,P. and Hurd,Y.L.
  TITLE     Chromatin accessibility mapping of the striatum identifies tyrosine
            kinase FYN as a therapeutic target for heroin use disorder
  JOURNAL   Nat Commun 11 (1), 4634 (2020)
   PUBMED   32929078
  REMARK    GeneRIF: Chromatin accessibility mapping of the striatum identifies
            tyrosine kinase FYN as a therapeutic target for heroin use
            disorder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Mao,L.M. and Wang,J.Q.
  TITLE     Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in
            Striatal Neurons in a Depression Model
  JOURNAL   Neuroscience 433, 11-20 (2020)
   PUBMED   32145272
  REMARK    GeneRIF: Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5
            Receptors in Striatal Neurons in a Depression Model.
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Grant,S.G., O'Dell,T.J., Karl,K.A., Stein,P.L., Soriano,P. and
            Kandel,E.R.
  TITLE     Impaired long-term potentiation, spatial learning, and hippocampal
            development in fyn mutant mice
  JOURNAL   Science 258 (5090), 1903-1910 (1992)
   PUBMED   1361685
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Bell,G.M., Bolen,J.B. and Imboden,J.B.
  TITLE     Association of Src-like protein tyrosine kinases with the CD2 cell
            surface molecule in rat T lymphocytes and natural killer cells
  JOURNAL   Mol Cell Biol 12 (12), 5548-5554 (1992)
   PUBMED   1280324
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Appleby,M.W., Gross,J.A., Cooke,M.P., Levin,S.D., Qian,X. and
            Perlmutter,R.M.
  TITLE     Defective T cell receptor signaling in mice lacking the thymic
            isoform of p59fyn
  JOURNAL   Cell 70 (5), 751-763 (1992)
   PUBMED   1516132
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Beyers,A.D., Spruyt,L.L. and Williams,A.F.
  TITLE     Molecular associations between the T-lymphocyte antigen receptor
            complex and the surface antigens CD2, CD4, or CD8 and CD5
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2945-2949 (1992)
   PUBMED   1372996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35365.1, SRR26643295.60207.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000020.1  44322664-44322773
            111-150             JAXUCZ010000020.1  44346789-44346828
            151-220             JAXUCZ010000020.1  44407131-44407200
            221-478             JAXUCZ010000020.1  44462141-44462398
            479-575             JAXUCZ010000020.1  44465992-44466088
            576-674             JAXUCZ010000020.1  44473109-44473207
            675-778             JAXUCZ010000020.1  44475735-44475838
            779-928             JAXUCZ010000020.1  44477285-44477434
            929-1093            JAXUCZ010000020.1  44480547-44480711
            1094-1273           JAXUCZ010000020.1  44483787-44483966
            1274-1350           JAXUCZ010000020.1  44485776-44485852
            1351-1504           JAXUCZ010000020.1  44485950-44486103
            1505-1636           JAXUCZ010000020.1  44501888-44502019
            1637-1845           JAXUCZ010000020.1  44513854-44514062
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..1845
                     /gene="Fyn"
                     /note="FYN proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:25150"
                     /db_xref="RGD:2641"
     exon            1..110
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            111..150
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..117
                     /gene="Fyn"
                     /note="upstream in-frame stop codon"
     exon            151..220
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            221..478
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1845
                     /gene="Fyn"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase Fyn; FYN
                     oncogene related to SRC, FGR, YES; p59-Fyn; proto-oncogene
                     c-Fyn"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fyn"
                     /protein_id="NP_036887.1"
                     /db_xref="GeneID:25150"
                     /db_xref="RGD:2641"
                     /translation="MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGV
                     TSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLS
                     FHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAE
                     RQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTR
                     AQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKR
                     LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS
                     EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLR
                     SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW
                     SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE
                     ERPTFEYLQGFLEDYFTATEPQYQPGENL"
     misc_feature    271..336
                     /gene="Fyn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62844.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    292..294
                     /gene="Fyn"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06241; propagated from
                     UniProtKB/Swiss-Prot (Q62844.1); phosphorylation site"
     misc_feature    307..309
                     /gene="Fyn"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06241; propagated from
                     UniProtKB/Swiss-Prot (Q62844.1); phosphorylation site"
     misc_feature    484..651
                     /gene="Fyn"
                     /note="Src homology 3 domain of Fyn and Yrk Protein
                     Tyrosine Kinases; Region: SH3_Fyn_Yrk; cd12006"
                     /db_xref="CDD:212939"
     misc_feature    484..651
                     /gene="Fyn"
                     /note="Src homology 3 domain of Fyn and Yrk Protein
                     Tyrosine Kinases; Region: SH3_Fyn_Yrk; cd12006"
                     /db_xref="CDD:212939"
     misc_feature    order(502..504,508..510,517..522,529..531,577..588,
                     625..627,631..633,637..642)
                     /gene="Fyn"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212939"
     misc_feature    order(502..504,508..510,517..522,529..531,577..588,
                     625..627,631..633,637..642)
                     /gene="Fyn"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212939"
     misc_feature    order(508..510,517..531,577..579,586..588,625..627)
                     /gene="Fyn"
                     /note="SAP interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212939"
     misc_feature    order(508..510,517..531,577..579,586..588,625..627)
                     /gene="Fyn"
                     /note="SAP interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212939"
     misc_feature    664..966
                     /gene="Fyn"
                     /note="Src homology 2 (SH2) domain found in Fyn isoform a
                     like proteins; Region: SH2_Src_Fyn_isoform_a_like;
                     cd10418"
                     /db_xref="CDD:198281"
     misc_feature    664..966
                     /gene="Fyn"
                     /note="Src homology 2 (SH2) domain found in Fyn isoform a
                     like proteins; Region: SH2_Src_Fyn_isoform_a_like;
                     cd10418"
                     /db_xref="CDD:198281"
     misc_feature    order(697..699,757..759,763..774,787..789,835..837,
                     841..843,940..942)
                     /gene="Fyn"
                     /note="autoinhibitory site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:198281"
     misc_feature    order(697..699,757..759,763..774,787..789,835..837,
                     841..843,940..942)
                     /gene="Fyn"
                     /note="autoinhibitory site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:198281"
     misc_feature    order(697..699,757..759,835..837,841..843)
                     /gene="Fyn"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198281"
     misc_feature    order(697..699,757..759,835..837,841..843)
                     /gene="Fyn"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198281"
     misc_feature    784..786
                     /gene="Fyn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P39688; propagated from
                     UniProtKB/Swiss-Prot (Q62844.1); phosphorylation site"
     misc_feature    order(838..840,922..924)
                     /gene="Fyn"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198281"
     misc_feature    order(838..840,922..924)
                     /gene="Fyn"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198281"
     misc_feature    1012..1833
                     /gene="Fyn"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fyn; Region: PTKc_Fyn; cd05070"
                     /db_xref="CDD:270655"
     misc_feature    1012..1833
                     /gene="Fyn"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fyn; Region: PTKc_Fyn; cd05070"
                     /db_xref="CDD:270655"
     misc_feature    order(1060..1062,1066..1074,1084..1086,1120..1122,
                     1126..1128,1255..1266,1276..1278,1399..1401,1411..1416,
                     1420..1422,1453..1455,1504..1518,1543..1545,1645..1647)
                     /gene="Fyn"
                     /note="active site"
                     /db_xref="CDD:270655"
     misc_feature    order(1060..1062,1066..1074,1084..1086,1120..1122,
                     1126..1128,1255..1266,1276..1278,1399..1401,1411..1416,
                     1420..1422,1453..1455,1504..1518,1543..1545,1645..1647)
                     /gene="Fyn"
                     /note="active site"
                     /db_xref="CDD:270655"
     misc_feature    order(1060..1062,1069..1071,1084..1086,1120..1122,
                     1126..1128,1255..1266,1276..1278,1399..1401,1405..1407,
                     1414..1416,1420..1422,1453..1455)
                     /gene="Fyn"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270655"
     misc_feature    order(1060..1062,1069..1071,1084..1086,1120..1122,
                     1126..1128,1255..1266,1276..1278,1399..1401,1405..1407,
                     1414..1416,1420..1422,1453..1455)
                     /gene="Fyn"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270655"
     misc_feature    order(1102..1104,1108..1110,1204..1206,1213..1215,
                     1219..1221,1258..1260,1336..1338,1348..1350,1432..1434,
                     1792..1794)
                     /gene="Fyn"
                     /note="SH3/SH2 domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:270655"
     misc_feature    order(1102..1104,1108..1110,1204..1206,1213..1215,
                     1219..1221,1258..1260,1336..1338,1348..1350,1432..1434,
                     1792..1794)
                     /gene="Fyn"
                     /note="SH3/SH2 domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:270655"
     misc_feature    order(1366..1368,1375..1380,1567..1569,1753..1761,
                     1765..1767,1771..1776,1783..1785,1795..1797,1804..1809,
                     1819..1821)
                     /gene="Fyn"
                     /note="CSK binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270655"
     misc_feature    order(1366..1368,1375..1380,1567..1569,1753..1761,
                     1765..1767,1771..1776,1783..1785,1795..1797,1804..1809,
                     1819..1821)
                     /gene="Fyn"
                     /note="CSK binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270655"
     misc_feature    order(1399..1401,1411..1413,1504..1518,1543..1545,
                     1645..1647)
                     /gene="Fyn"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270655"
     misc_feature    order(1399..1401,1411..1413,1504..1518,1543..1545,
                     1645..1647)
                     /gene="Fyn"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270655"
     misc_feature    1450..1524
                     /gene="Fyn"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270655"
     misc_feature    1450..1524
                     /gene="Fyn"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270655"
     misc_feature    1489..1491
                     /gene="Fyn"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P39688; propagated from
                     UniProtKB/Swiss-Prot (Q62844.1); phosphorylation site"
     misc_feature    1822..1824
                     /gene="Fyn"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q62844.1); phosphorylation site"
     exon            479..575
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            576..674
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            675..778
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            779..928
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1093
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1273
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1350
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1504
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1636
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1845
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctcctgg gcccggccgc ggagccaccg gagccgccag ggcctcgccg gaggagggcg
       61 gggagaggac catgtgaatg tgctccggaa ccgagcgcca cgccacgcag tgtttgaaag
      121 gaacacaatg ctgatctagt cgtggcaaaa ggtcagtcct actgctggtt tagaagacat
      181 gtggtgtata taacgtttgt gatagttggt ggaaatttgg gagcttggat aatgggctgt
      241 gtgcaatgta aggataaaga agcagcgaaa ctgacggagg agagggacgg cagcctgaac
      301 cagagctctg ggtaccgcta tggcacagac cccacccctc agcactaccc cagcttcggt
      361 gtgacctcca tcccgaacta caacaacttc cacgcagccg ggggccaggg actcacggtc
      421 tttgggggtg tgaactcctc ctctcacacc gggaccctgc gtactagagg agggacagga
      481 gtgacactat ttgtggcact ttatgactat gaagcacgga cagaagatga cctgagtttt
      541 cacaaaggag aaaaatttca aatattgaac agctcggaag gagactggtg ggaagcccgc
      601 tccttgacaa ctggggaaac tggttacatt cctagcaact acgtggctcc agttgactcc
      661 atccaggcag aagagtggta ctttggaaaa cttggccgca aggatgctga gagacagctc
      721 ctgtcctttg gaaacccaag aggtaccttt cttatccgcg agagcgaaac caccaaaggt
      781 gcctactccc tctccatccg agactgggac gacatgaagg gagaccacgt caaacattac
      841 aaaatccgca agcttgacaa cggcgggtac tacatcacca cgagggccca gtttgagacc
      901 cttcagcagc ttgtacagca ttactcagag agagccgcgg gtctctgctg ccgtctagta
      961 gttccctgtc acaaagggat gccaaggctt accgatctgt ctgtcaaaac caaagatgtc
     1021 tgggaaatcc ctcgagaatc cctgcagttg atcaagagac tgggaaatgg gcagtttggg
     1081 gaagtatgga tgggtacctg gaatggaaac acaaaagtag ccataaagac tcttaagcca
     1141 ggcacaatgt ccccggaatc cttcctggag gaagcacaga tcatgaagaa gctgaagcac
     1201 gacaagctgg tgcagctcta tgcagttgtg tccgaagagc ccatttacat tgtcacggaa
     1261 tacatgaaca aaggaagttt gctcgacttc ttaaaagacg gtgaaggacg ggctctgaaa
     1321 ttgccaaacc tcgtggacat ggcggcacag gttgctgcag gaatggctta catcgaacgc
     1381 atgaattata tccacagaga tctgcggtca gctaacattc tggtggggaa cggactcatt
     1441 tgcaagattg ctgacttcgg attggcccgg ttgattgaag acaatgagta cacagccaga
     1501 caaggtgcaa agtttcccat taagtggaca gcccccgaag cggccctgta tggaaggttc
     1561 acaatcaagt ctgacgtgtg gtcctttgga atcttactca cagagctggt caccaaaggc
     1621 agagtgccgt acccaggcat gaacaaccgt gaggtgctgg agcaggtgga gagaggctac
     1681 aggatgccct gcccgcagga ctgcccgatc tccctgcacg agctcatgat ccactgctgg
     1741 aaaaaggatc cggaggagcg ccccactttc gagtacttgc agggcttcct ggaggactac
     1801 tttaccgcca cagagcccca gtatcagccc ggtgaaaacc tgtga
//
LOCUS       NM_001099517            2532 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 72 (Vom2r72), mRNA.
ACCESSION   NM_001099517 XM_001068097 XM_001068149 XM_001068193
VERSION     NM_001099517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001099517.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000014.1  1039097-1039302     c
            207-489             JAXUCZ010000014.1  1036228-1036510     c
            490-1296            JAXUCZ010000014.1  1035033-1035839     c
            1297-1521           JAXUCZ010000014.1  1033950-1034174     c
            1522-1645           JAXUCZ010000014.1  1032952-1033075     c
            1646-2532           JAXUCZ010000014.1  1031844-1032730     c
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2532
                     /gene="Vom2r72"
                     /note="vomeronasal 2 receptor, 72"
                     /db_xref="GeneID:689072"
                     /db_xref="RGD:1597414"
     CDS             1..2532
                     /gene="Vom2r72"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 72"
                     /protein_id="NP_001092987.2"
                     /db_xref="GeneID:689072"
                     /db_xref="RGD:1597414"
                     /translation="MKKLCAFPITFLILKFSLIYFHLTEPSCFWRIKNSEETDGDLRS
                     DCGFVLLAFEEPIEENYYNELINFRIPATKYEFFLVMFFATDEINKNPDLLPNMSLIF
                     NLVGRMCEDTLGLLDEIYSQENKTSYIINYVCGIELSCDIDLIGPSRTTSLKLAIHSM
                     MPKVFFGPFNSNLIDHDQFPYIYQIAIKDTCLPHGMVSLMLQFGWTWVGLIISDNDQG
                     IQFFSDLREEMQRHGICLAFVNVIPETMQRYSTRAKIYDKQLMTSSAKVVIIYGEMNS
                     TLEVSFRRWAYLGVQRIWVTNSQWDVIINKRDFSLDFFHGTVTFAHHHSGMTIFRNVM
                     QTMNTSKYPIDLSQSMLGWNYFNCSISENRHSKTDHFTFNNTLEWLALHKFDMVLSEE
                     GYNLYNAVYAVAHTYHELISQNVESQKVAEPKGLFTDCQQVASLLKATVFTNPVGELV
                     NMNHRENQCAEYDIFIIWNFPEGLGLKVKIASYFPCFPHNQQLHTSEDLEWATEGTLV
                     PSSMCSATCTAGFRKIHQKQTADCCFDCVQCPENEVSNETADMEQCARCPDDKYANSE
                     QTYCLQRTVSFLAYEDPLGMALGCMALFFSAITILVLVTFVKYKDTPIVKANNCILSY
                     ILLISLIFCFLCSLLFIGHPNKATCILQQTTFGVFFTVAVSAVLAKTVTVVMAFKLTT
                     PGRRMRGMLASGATNLVIPICTLIQLVLYGIWLAISPPFIDRDIQSEHGKTIIICNKG
                     SVIAFHFVLGYLGSLALGSITVAFLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYH
                     STRGKVMVVVEVFSILASSAGLLGCIFVPKCYVILVRPDLNFLQK"
     misc_feature    133..1503
                     /gene="Vom2r72"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    133..1503
                     /gene="Vom2r72"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1174..1176)
                     /gene="Vom2r72"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1174..1176)
                     /gene="Vom2r72"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,469..471,721..723)
                     /gene="Vom2r72"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,469..471,721..723)
                     /gene="Vom2r72"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1525..1689
                     /gene="Vom2r72"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1525..1689
                     /gene="Vom2r72"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1747..2502
                     /gene="Vom2r72"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..2502
                     /gene="Vom2r72"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r72"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r72"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r72"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r72"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r72"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r72"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r72"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r72"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r72"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r72"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r72"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r72"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r72"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r72"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r72"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r72"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r72"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r72"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
     exon            207..489
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1296
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1521
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1645
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2532
                     /gene="Vom2r72"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaagt tgtgtgcttt ccctattacc tttttgatcc tgaaattttc tctaatctat
       61 ttccatttga ctgaacccag ttgcttttgg aggataaaga atagtgaaga gactgatgga
      121 gatttgcgaa gtgactgtgg ttttgtcctt ttggcatttg aggaacctat tgaagaaaat
      181 tattataatg aacttattaa ttttagaata ccagcaacaa aatatgagtt ttttctggta
      241 atgttttttg ctactgatga gatcaacaag aatcctgatc ttttacccaa catgtctttg
      301 atattcaacc ttgttggtag aatgtgtgaa gatacattgg gacttctgga tgaaatatat
      361 tcacaagaaa acaaaacttc gtatattatt aattatgtct gtggaataga actatcttgt
      421 gacatagatc ttatagggcc atcacggaca acatccttaa aactggcaat tcattccatg
      481 atgccaaagg ttttctttgg accatttaac tctaacctaa tagaccatga ccagtttccc
      541 tatatctatc agatagcaat caaagacaca tgtttgcccc atggcatggt atccttgatg
      601 cttcaatttg gatggacttg ggtaggactg atcatctcag ataatgacca gggtattcag
      661 tttttctcag acttgagaga agaaatgcaa aggcatggga tctgtttggc ttttgtgaat
      721 gtgatcccag aaaccatgca gagatacagc acaagggcta agatatatga taaacaactt
      781 atgacatcat cagcaaaggt tgttatcatt tatggtgaaa tgaactctac tctagaagtc
      841 agctttcgaa gatgggcata tttaggtgta caaagaatct gggtcacgaa ctcacaatgg
      901 gatgtcatca taaataaaag agatttcagc cttgatttct tccacgggac tgtcactttt
      961 gcacaccacc acagtgggat gactatattt aggaatgtta tgcaaacaat gaacacttcc
     1021 aagtacccaa tagacctttc tcagtctatg ctagggtgga attattttaa ttgttcaatc
     1081 tctgagaata gacatagcaa aacggatcat tttacattca acaatacatt agaatggtta
     1141 gcactgcata aatttgacat ggtcctgagt gaagaaggtt ataatttgta taatgctgtg
     1201 tatgctgtgg cccacaccta ccatgaactc atttctcaaa atgtagagtc tcagaaagtg
     1261 gcagaaccca aaggattatt cactgactgt cagcaggtgg cttccttgct gaaagccacg
     1321 gtatttacta accctgttgg agaactggtg aacatgaacc atagggaaaa tcagtgtgca
     1381 gagtatgaca ttttcatcat ttggaatttt cctgagggcc ttggattaaa agtgaaaata
     1441 gcaagctatt ttccttgttt cccacataat caacaacttc atacatctga agacttggaa
     1501 tgggccacag aaggaacatt ggttccatcc tccatgtgta gtgcaacatg tactgctgga
     1561 ttcaggaaaa ttcatcagaa acaaacagca gactgctgct ttgattgtgt tcagtgccca
     1621 gaaaatgagg tttccaatga gacagcagat atggaacagt gtgcgaggtg tccagatgat
     1681 aaatatgcca actcagagca gacctactgc ctacaaagaa ctgtgtcatt tctggcttat
     1741 gaagatccac tggggatggc tctaggctgc atggcgctgt tcttctcagc catcacaatt
     1801 ctagtactag tcacttttgt gaagtacaag gatactccca ttgtgaaagc caataactgt
     1861 attctcagct acatcctgct catctctctc atcttctgtt ttctctgttc attgctcttc
     1921 attggacatc ccaacaaggc cacctgcatc ctgcagcaga caacatttgg agtgtttttc
     1981 actgtggctg tttctgcagt gttggccaaa acagtaactg tggtcatggc ttttaagctc
     2041 actactccag gcagaaggat gagagggatg ctggcctcag gggcaactaa cttggtcatt
     2101 cccatttgta ccctaatcca acttgttctc tatggaatct ggttggcaat atctcctccc
     2161 tttattgaca gagatataca atctgaacat gggaagacca tcattatttg caacaaaggc
     2221 tcagtcattg ccttccactt tgtcctggga tatttgggct ccttggctct ggggagcatc
     2281 actgtggctt tcttggctag gaaccttcct gacagattca atgaagccaa gttcctaact
     2341 ttcagcatgt tggtgttcta cagtgtatgg atcaccttcc tccctgtcta ccacagcacc
     2401 agagggaagg ttatggtagt tgtggaggtc ttttccattt tggcttctag tgcagggttg
     2461 ctcgggtgta tctttgtccc aaagtgttat gttattttag ttagaccaga tttaaatttt
     2521 cttcagaagt aa
//
LOCUS       NM_001099462            2529 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 5 (Vom2r5), mRNA.
ACCESSION   NM_001099462 XM_001053048 XM_001053116
VERSION     NM_001099462.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2529)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XM_001053116.1, XM_001053048.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  2973745-2973950
            207-489             JAXUCZ010000001.1  2976521-2976803
            490-1293            JAXUCZ010000001.1  2977192-2977995
            1294-1518           JAXUCZ010000001.1  2978846-2979070
            1519-1642           JAXUCZ010000001.1  2980246-2980369
            1643-2529           JAXUCZ010000001.1  2981512-2982398
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..2529
                     /gene="Vom2r5"
                     /note="vomeronasal 2 receptor, 5"
                     /db_xref="GeneID:679691"
                     /db_xref="RGD:1585898"
     CDS             1..2529
                     /gene="Vom2r5"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 5 precursor"
                     /protein_id="NP_001092932.1"
                     /db_xref="GeneID:679691"
                     /db_xref="RGD:1585898"
                     /translation="MKKLCAFTIAIFSLKFCLILCSLTEPNCFWRIKSSEDNDGDLRS
                     DCGFVLFTHEGPIPEDFYNDIINFRIPARKYEFFLVLLFATDEINKNPYLLPNMSLIF
                     NIIFGLCEDTLGVLDKAYLHQNSNSELFNYYCGINQLCDVDLTGPSWTTSLKLSIYSR
                     TPKIFFGSFNPNLSDHDQFPYIYQIAAKDTYLFHGMVSLMFHFGWTWIGLVISDDDQG
                     IQFLSDLREEMQRHAICLAFVNMIPETMQIYKTRVKIYDQQLMTSSAKVVIIYGEVNS
                     TLELSFRRWAYLGAQRIWITTSQWDVITHKKDFSLDFSHGTVTFAHHHNDIAVFRNFM
                     QTINTSMYPVDISQSMLQWNHFNCSISKNKKKMDCFTFKNPLEWLIQHTFDMVLSEEG
                     YNLYNAVYAVAHTYHKLIFQQVESQKMEEPKGLFTDCQQVTSLLKTIEFTNPVGELVD
                     TKHKENQCATYDIFITWNFPQGLGLKVKIGSYFPCLPQSQQLHISEDWEWVTGETLIP
                     PSVCSMTCTAGFRKIHQKETADCCFDCVQCQENEIANDTADMEQCVKCPDDSYANLEQ
                     SQCLQRVVTFLAYEDPLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYI
                     LLISLVFCFLCSLLYIGHPNQATCILQQTTFAIFFTVAISTVLAKTITVVTAFKLTTP
                     ERRIKKIMIKGAINLLIPICTLIQLVLCAVWLVISPPFIDRDIQSEHGKVIIICNKGS
                     VIAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYHS
                     TRGKDMVIVEVFSILASSAGLLGCIFFQKCYVLLVRPDLNVLRK"
     sig_peptide     1..78
                     /gene="Vom2r5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    133..1500
                     /gene="Vom2r5"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    133..1500
                     /gene="Vom2r5"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r5"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r5"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1522..1686
                     /gene="Vom2r5"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1522..1686
                     /gene="Vom2r5"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1744..2499
                     /gene="Vom2r5"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..2499
                     /gene="Vom2r5"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..1821
                     /gene="Vom2r5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1744..1821
                     /gene="Vom2r5"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1753..1755,1762..1767,1774..1779,1783..1788,
                     1888..1890,1900..1902,1909..1914,1936..1938,1948..1950)
                     /gene="Vom2r5"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1753..1755,1762..1767,1774..1779,1783..1788,
                     1888..1890,1900..1902,1909..1914,1936..1938,1948..1950)
                     /gene="Vom2r5"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1855..1920
                     /gene="Vom2r5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1855..1920
                     /gene="Vom2r5"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1915..1917,1951..1956,1963..1968,1975..1977,
                     2215..2217,2230..2232,2239..2244,2251..2253,2353..2355,
                     2362..2367,2374..2376,2386..2388,2410..2415,2422..2424,
                     2431..2433,2443..2445)
                     /gene="Vom2r5"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1915..1917,1951..1956,1963..1968,1975..1977,
                     2215..2217,2230..2232,2239..2244,2251..2253,2353..2355,
                     2362..2367,2374..2376,2386..2388,2410..2415,2422..2424,
                     2431..2433,2443..2445)
                     /gene="Vom2r5"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1945..2019
                     /gene="Vom2r5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1945..2019
                     /gene="Vom2r5"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2089..2139
                     /gene="Vom2r5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2089..2139
                     /gene="Vom2r5"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2218..2298
                     /gene="Vom2r5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2218..2298
                     /gene="Vom2r5"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2320..2391
                     /gene="Vom2r5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2320..2391
                     /gene="Vom2r5"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2404..2481
                     /gene="Vom2r5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2404..2481
                     /gene="Vom2r5"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
     exon            207..489
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1293
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1518
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1642
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2529
                     /gene="Vom2r5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaagc tgtgtgcttt cactattgcc attttttccc tgaagttttg tctcatcttg
       61 tgcagtttga ctgaacccaa ctgcttttgg aggataaaga gtagtgaaga taatgatgga
      121 gatttgcgaa gtgactgtgg ttttgttctt tttacacacg agggccctat tccagaagat
      181 ttttataatg acattattaa ttttaggata ccagcaagaa aatatgagtt ttttctggta
      241 ttgttatttg caactgatga gatcaacaag aatccttatc ttttgcccaa catgtctttg
      301 atatttaaca tcatttttgg cctgtgtgaa gatacattgg gagttctgga taaagcatat
      361 ttacatcaaa acagcaattc tgaactattt aattattact gtggtataaa tcaactttgt
      421 gatgtagacc ttacaggacc atcatggaca acatccttaa aactatcaat ttattcaaga
      481 acaccaaaga ttttctttgg ctcatttaac cctaatctga gtgaccatga ccagtttccc
      541 tatatctatc agatagcagc caaggacaca tatttgttcc atggcatggt ctccttgatg
      601 tttcattttg gatggacttg gataggactg gtcatctcag atgatgacca aggtattcag
      661 tttctttcag acttgagaga agaaatgcaa aggcatgcaa tctgtttagc ttttgtgaat
      721 atgatcccag aaaccatgca gatatacaag acaagagtta agatatatga ccaacaactt
      781 atgacatctt cagcaaaggt tgttatcatt tatggagaag tgaactccac tctagaactc
      841 agctttagaa gatgggcata tttaggtgca cagagaatct ggatcacaac ctcacaatgg
      901 gatgtcatca cacataaaaa agatttcagc cttgatttct cccacgggac tgtcactttt
      961 gcccaccacc acaatgacat tgctgtattt agaaatttta tgcaaacaat aaacacatcc
     1021 atgtatccgg tagacatttc gcagtctatg ctgcagtgga atcattttaa ctgttcaatc
     1081 tcaaagaaca agaagaaaat ggattgtttt acgttcaaaa acccattaga atggttaata
     1141 cagcatacat ttgacatggt cctgagtgaa gaaggttaca atttgtataa tgctgtgtat
     1201 gctgtggccc acacctacca taaactcatt tttcaacaag tagagtctca gaaaatggaa
     1261 gaacccaaag gattattcac cgactgtcag caggtgactt ctttgctgaa aactattgaa
     1321 tttactaacc ctgttggaga actggtggac acgaaacata aggaaaatca gtgtgccacg
     1381 tatgacattt tcatcacttg gaattttcca caaggcctcg gattaaaagt gaaaatagga
     1441 agctattttc cttgtttgcc acagagtcaa caacttcata tatctgaaga ctgggagtgg
     1501 gtcacaggag aaacattgat tcccccctca gtgtgtagta tgacatgtac tgcaggattc
     1561 agaaaaattc atcagaaaga aacagccgat tgctgctttg attgtgtcca gtgtcaagaa
     1621 aatgagattg ccaatgatac agcagatatg gagcagtgtg tgaaatgtcc agatgattca
     1681 tatgccaact tagaacaaag ccagtgtctc caaagagtgg tgacatttct cgcttatgaa
     1741 gatccactgg gcatggctct aggctgcatg gccctgtcct tctcagccat cacaatccta
     1801 gtcctggtca cttttgtgaa gtacaaagat acacccattg tgaaagccaa caaccgcatt
     1861 ctcagctaca tcctgctcat atctctagtc ttctgttttc tctgctcatt gctctacatt
     1921 ggacacccca accaggccac ctgcatcctg cagcagacca catttgcaat atttttcact
     1981 gttgctattt ctactgtgtt ggccaaaaca ataactgtgg tcacagcttt caagctcact
     2041 actccagaga gaaggataaa aaagataatg ataaaagggg caattaactt gctcattccc
     2101 atttgcaccc taatccaact tgttctctgt gcagtctggt tggtgatatc tcctccattt
     2161 attgacagag atatacaatc tgaacatggg aaggtaatca tcatttgcaa caaaggctca
     2221 gtcattgcct tccactttgt cttgggatat ttgggctcct tggctctggg gagcttcact
     2281 gtggctttct tggctaggaa ccttcctgac agattcaatg aggccaagtt cttaacattc
     2341 agcatgttgg tgttctacag tgtttggatc accttcctcc ctgtctacca cagcaccagg
     2401 gggaaggata tggttattgt ggaggttttc tccatcttgg cttctagtgc agggttgcta
     2461 gggtgtatat ttttccaaaa gtgttatgtt cttttagttc gaccagattt aaatgttctt
     2521 cggaaatag
//
LOCUS       NM_030584                669 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sclerostin (Sost), mRNA.
ACCESSION   NM_030584
VERSION     NM_030584.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Osumi,R., Wang,Z., Ishihara,Y., Odagaki,N., Iimura,T. and
            Kamioka,H.
  TITLE     Changes in the intra- and peri-cellular sclerostin distribution in
            lacuno-canalicular system induced by mechanical unloading
  JOURNAL   J Bone Miner Metab 39 (2), 148-159 (2021)
   PUBMED   32844318
  REMARK    GeneRIF: Changes in the intra- and peri-cellular sclerostin
            distribution in lacuno-canalicular system induced by mechanical
            unloading.
            Erratum:[J Bone Miner Metab. 2021 Mar;39(2):160-162. doi:
            10.1007/s00774-020-01155-5. PMID: 33025107]
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Huang,Y., Wang,X., Wu,F., Lu,Y., Liang,G. and Liu,A.
  TITLE     The Possible Role of Sclerostin in the Pathogenesis of
            Tympanosclerosis
  JOURNAL   Audiol Neurootol 26 (2), 102-110 (2021)
   PUBMED   33508832
  REMARK    GeneRIF: The Possible Role of Sclerostin in the Pathogenesis of
            Tympanosclerosis.
REFERENCE   3  (bases 1 to 669)
  AUTHORS   De Mare,A., Maudsley,S., Azmi,A., Hendrickx,J.O., Opdebeeck,B.,
            Neven,E., D'Haese,P.C. and Verhulst,A.
  TITLE     Sclerostin as Regulatory Molecule in Vascular Media Calcification
            and the Bone-Vascular Axis
  JOURNAL   Toxins (Basel) 11 (7), 428 (2019)
   PUBMED   31330917
  REMARK    GeneRIF: Sclerostin as Regulatory Molecule in Vascular Media
            Calcification and the Bone-Vascular Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Korn,P., Kramer,I., Schlottig,F., Todtman,N., Eckelt,U., Burki,A.,
            Ferguson,S.J., Kautz,A., Schnabelrauch,M., Range,U., Kneissel,M.
            and Stadlinger,B.
  TITLE     Systemic sclerostin antibody treatment increases osseointegration
            and biomechanical competence of zoledronic-acid-coated dental
            implants in a rat osteoporosis model
  JOURNAL   Eur Cell Mater 37, 333-346 (2019)
   PUBMED   31112281
  REMARK    GeneRIF: The combination of ZOL and the osteoanabolic sclerostin
            antibody was more effective than either agent alone.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Wang,J., Qiu,X., Xu,T., Sheng,Z. and Yao,L.
  TITLE     Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract
            Alleviates beta-Glycerophosphate-Induced Vascular Smooth Muscle
            Cell Calcification By Inhibiting Wnt/beta-Catenin Pathway
  JOURNAL   Blood Purif 47 Suppl 1 (Suppl 1), 17-23 (2019)
   PUBMED   30699436
  REMARK    GeneRIF: beta-GP induced VSMC calcification by activating the
            Wnt/beta-catenin signaling pathway. Sclerostin and Lrp4 were
            involved in beta-GP-induced VSMC calcification and play an
            important role. GBE could alleviate VSMC calcification induced by
            beta-GP through inhibiting the Wnt/beta-catenin signaling pathway.
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Keller,H. and Kneissel,M.
  TITLE     SOST is a target gene for PTH in bone
  JOURNAL   Bone 37 (2), 148-158 (2005)
   PUBMED   15946907
  REMARK    GeneRIF: SOST regulation may play a role in mediating PTH action in
            bone
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Semenov,M., Tamai,K. and He,X.
  TITLE     SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
  JOURNAL   J Biol Chem 280 (29), 26770-26775 (2005)
   PUBMED   15908424
REFERENCE   8  (bases 1 to 669)
  AUTHORS   Winkler,D.G., Yu,C., Geoghegan,J.C., Ojala,E.W., Skonier,J.E.,
            Shpektor,D., Sutherland,M.K. and Latham,J.A.
  TITLE     Noggin and sclerostin bone morphogenetic protein antagonists form a
            mutually inhibitory complex
  JOURNAL   J Biol Chem 279 (35), 36293-36298 (2004)
   PUBMED   15199066
  REMARK    GeneRIF: noggin and sclerostin form a mutually inhibitory complex
            that fine-tunes of BMP activity in bone homeostasis
REFERENCE   9  (bases 1 to 669)
  AUTHORS   Winkler,D.G., Sutherland,M.K., Geoghegan,J.C., Yu,C., Hayes,T.,
            Skonier,J.E., Shpektor,D., Jonas,M., Kovacevich,B.R.,
            Staehling-Hampton,K., Appleby,M., Brunkow,M.E. and Latham,J.A.
  TITLE     Osteocyte control of bone formation via sclerostin, a novel BMP
            antagonist
  JOURNAL   EMBO J 22 (23), 6267-6276 (2003)
   PUBMED   14633986
REFERENCE   10 (bases 1 to 669)
  AUTHORS   Brunkow,M.E., Gardner,J.C., Van Ness,J., Paeper,B.W.,
            Kovacevich,B.R., Proll,S., Skonier,J.E., Zhao,L., Sabo,P.J., Fu,Y.,
            Alisch,R.S., Gillett,L., Colbert,T., Tacconi,P., Galas,D.,
            Hamersma,H., Beighton,P. and Mulligan,J.
  TITLE     Bone dysplasia sclerosteosis results from loss of the SOST gene
            product, a novel cystine knot-containing protein
  JOURNAL   Am J Hum Genet 68 (3), 577-589 (2001)
   PUBMED   11179006
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030584.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326741.1, BE101082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000010.1  87415520-87415766   c
            248-669             JAXUCZ010000010.1  87412722-87413143   c
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..669
                     /gene="Sost"
                     /note="sclerostin"
                     /db_xref="GeneID:80722"
                     /db_xref="RGD:69358"
     exon            1..247
                     /gene="Sost"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..669
                     /gene="Sost"
                     /note="sclerosteosis"
                     /codon_start=1
                     /product="sclerostin precursor"
                     /protein_id="NP_085073.1"
                     /db_xref="GeneID:80722"
                     /db_xref="RGD:69358"
                     /translation="MQLSLAPCLACLLVHAAFVAVESQGWQAFKNDATEIIPGLREYP
                     EPPQELENNQTMNRAENGGRPPHHPYDTKDVSEYSCRELHYTRFVTDGPCRSAKPVTE
                     LVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVR
                     LVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPRARGAKANQAELENAY"
     misc_feature    28..657
                     /gene="Sost"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl21545"
                     /db_xref="CDD:473907"
     misc_feature    28..657
                     /gene="Sost"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl21545"
                     /db_xref="CDD:473907"
     sig_peptide     28..111
                     /gene="Sost"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P67.1)"
     mat_peptide     112..666
                     /gene="Sost"
                     /product="Sclerostin. /id=PRO_0000033179"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P67.1)"
     misc_feature    184..186
                     /gene="Sost"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P67.1); glycosylation site"
     misc_feature    550..552
                     /gene="Sost"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P67.1); glycosylation site"
     misc_feature    559..666
                     /gene="Sost"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P67.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            248..669
                     /gene="Sost"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgagtgcc ctcctccttc tggcaccatg cagctctcac tagccccttg ccttgcctgc
       61 ctgcttgtac atgcagcctt cgttgctgtg gagagccagg ggtggcaagc cttcaagaat
      121 gatgccacag aaatcatccc gggactcaga gagtacccag agcctcctca ggaactagag
      181 aacaaccaga ccatgaaccg ggccgagaac ggaggcagac ccccccacca tccttatgac
      241 accaaagacg tgtccgagta cagctgccgc gagctgcact acacccgctt cgtgaccgac
      301 ggcccgtgcc gcagtgccaa gccggtcacc gagttggtgt gctcgggcca gtgcggcccc
      361 gcgcggctgc tgcccaacgc catcgggcgc gtgaagtggt ggcgcccgaa cggacccgac
      421 ttccgctgca tcccggatcg ctaccgcgcg cagcgggtgc agctgctgtg ccccggcggc
      481 gcggcgccgc gctcgcgcaa ggtgcgtctg gtggcctcgt gcaagtgcaa gcgcctcacc
      541 cgcttccaca accagtcgga gctcaaggac ttcggacctg agaccgcgcg gccgcagaag
      601 ggtcgcaagc cgcggccccg cgcccgggga gccaaagcca accaggcgga gctggagaac
      661 gcctactag
//
LOCUS       NM_001191781            1290 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus amidohydrolase domain containing 1 (Amdhd1),
            mRNA.
ACCESSION   NM_001191781 XM_235065
VERSION     NM_001191781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_235065.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.22356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000007.1  29946054-29946199   c
            147-253             JAXUCZ010000007.1  29943706-29943812   c
            254-318             JAXUCZ010000007.1  29943083-29943147   c
            319-596             JAXUCZ010000007.1  29940586-29940863   c
            597-822             JAXUCZ010000007.1  29937895-29938120   c
            823-947             JAXUCZ010000007.1  29933665-29933789   c
            948-1041            JAXUCZ010000007.1  29933258-29933351   c
            1042-1202           JAXUCZ010000007.1  29932282-29932442   c
            1203-1290           JAXUCZ010000007.1  29930966-29931053   c
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1290
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /note="amidohydrolase domain containing 1"
                     /db_xref="GeneID:299735"
                     /db_xref="RGD:1308879"
     exon            1..146
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1290
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /EC_number="3.5.2.7"
                     /codon_start=1
                     /product="probable imidazolonepropionase"
                     /protein_id="NP_001178710.1"
                     /db_xref="GeneID:299735"
                     /db_xref="RGD:1308879"
                     /translation="MNGHRLLLENAQQVVLVCARGELYLTGSELRSLAVLEGASLVVG
                     TDGLIKAVGPADIIRRQFSGETFEERIDCSGKCILPGLVDAHTHPVWAGERVHEFAMK
                     LAGATYMDIHQAGGGINFTVEHTRQASEEELFRSFQQRLQCMMRAGTTLVECKSGYGL
                     NLETELKMLRVIERARRELHLSLSATYCGAHSVPKGKTAVEAADDIISHHLPRLKELS
                     EKGELHVDNIDVFCEKGVFDLDTTRRILEGGKKVGLQINFHGDELHPMKAAELGAELG
                     ARAISHLEEVSDEGIAAMAAAQCSAVLLPTTAYMLRLKQPRARKMLDEGVIVALGSDF
                     NPNAYCFSMPMVMHLACVNMRMSMPEALAAATINAAYALGKSHTHGSLEVGKQGDAII
                     INASRWEHLIYQFGGHQELIDYVITKGKVIYKK"
     misc_feature    136..1269
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /note="Imidazolonepropionase/imidazolone-5-propionate
                     hydrolase (Imidazolone-5PH) catalyzes the third step in
                     the histidine degradation pathway, the hydrolysis of
                     (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to
                     N-formimidoyl-L-glutamate. In bacteria; Region:
                     Imidazolone-5PH; cd01296"
                     /db_xref="CDD:238621"
     misc_feature    136..1269
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /note="Imidazolonepropionase/imidazolone-5-propionate
                     hydrolase (Imidazolone-5PH) catalyzes the third step in
                     the histidine degradation pathway, the hydrolysis of
                     (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to
                     N-formimidoyl-L-glutamate. In bacteria; Region:
                     Imidazolone-5PH; cd01296"
                     /db_xref="CDD:238621"
     misc_feature    order(268..270,274..276,787..789,796..798,856..858,
                     1009..1011)
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /note="active site"
                     /db_xref="CDD:238621"
     misc_feature    order(268..270,274..276,787..789,796..798,856..858,
                     1009..1011)
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /note="active site"
                     /db_xref="CDD:238621"
     exon            147..253
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            254..318
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            319..596
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            597..822
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            823..947
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1041
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1202
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1290
                     /gene="Amdhd1"
                     /gene_synonym="RGD1308879"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggacgacca agatgaatgg ccaccgcctc ctgctggaga acgctcagca agtggtgctg
       61 gtgtgtgccc gcggagagct atatctgaca gggtctgagc tgcgcagcct ggcagtgctg
      121 gagggcgcca gcctggtggt gggcactgat gggcttataa aagctgttgg ccctgctgac
      181 attatccgaa gacagttttc cggagaaacg tttgaagaaa gaattgattg ctctggaaaa
      241 tgcatcttgc caggtttggt ggacgcgcac acacatccgg tgtgggctgg tgaaagagtc
      301 catgagtttg caatgaagtt ggcaggggcc acgtacatgg acatccacca ggctggagga
      361 gggatcaact tcacggtgga gcacacgcgc caagcctcgg aggaggaact gttccgctcc
      421 ttccagcagc ggctgcagtg catgatgagg gccggcacca cactggtgga gtgcaagagc
      481 ggatatggcc tcaacctgga gacagagctc aagatgctgc gtgtaatcga gcgtgcccgg
      541 cgggagctgc acctcagcct ctctgccact tactgtgggg ctcactcagt acccaaaggg
      601 aaaactgctg tggaagctgc tgatgacatc atcagtcacc acctgccaag gctgaaggaa
      661 ctcagcgaaa agggggaact gcatgtggac aacatagacg tgttctgtga gaagggcgtc
      721 tttgatctgg ataccaccag aaggattctg gaaggtggaa aaaaggtggg gttacagatc
      781 aacttccacg gggatgaact ccacccaatg aaggccgctg agcttggggc ggaactagga
      841 gcacgggcga tcagccacct ggaggaagtc agcgatgaag gcatcgctgc catggctgcg
      901 gcccagtgtt ccgctgtcct tctgcccacc acggcctaca tgctgaggct gaagcagcct
      961 cgcgccagga agatgctaga tgagggagtc atagttgctc tgggcagcga tttcaacccc
     1021 aacgcgtact gcttttccat gcctatggtc atgcacctgg cctgtgtgaa catgaggatg
     1081 tccatgccag aggctttggc cgctgccacc atcaatgcgg cttatgcact gggaaagtct
     1141 cacacccacg gatctttgga agttggcaag cagggggatg ccatcatcat caatgcatcc
     1201 agatgggagc atttgattta ccagtttgga ggccatcaag aattaattga ttatgttata
     1261 actaaaggaa aagtcatcta taaaaagtga
//
LOCUS       NM_001099469            2577 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 10 (Vom2r10), mRNA.
ACCESSION   NM_001099469 XM_001058365 XM_218017
VERSION     NM_001099469.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2577)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On or before Aug 19, 2007 this sequence version replaced
            XM_218017.4, XM_001058365.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000001.1  67700833-67701053
            222-516             JAXUCZ010000001.1  67711487-67711781
            517-1308            JAXUCZ010000001.1  67712117-67712908
            1309-1524           JAXUCZ010000001.1  67720774-67720989
            1525-1648           JAXUCZ010000001.1  67723056-67723179
            1649-2577           JAXUCZ010000001.1  67747460-67748388
FEATURES             Location/Qualifiers
     source          1..2577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2577
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="vomeronasal 2 receptor, 10"
                     /db_xref="GeneID:292414"
                     /db_xref="RGD:1565464"
     CDS             1..2577
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 10"
                     /protein_id="NP_001092939.1"
                     /db_xref="GeneID:292414"
                     /db_xref="RGD:1565464"
                     /translation="MMFSWIFIFWLLQILKFVSAIVFNISRCYYIITEEFHHEGDIVI
                     GAFFPLHTFYTGKKMPDPTLPYQYLDNYIQYNFRNYQYILALLFAIEEINGNPNLLPN
                     ISLGFDFYNVRFTEKETLMNAVIWLTAHVQRKVLPNYNCKKKKFSAALTGTSWTTSAQ
                     IGTLLQLFKFPQITFGPYDPLLSDHGQYSSLYQMAPKDTSLSLAIVSLMVYFRWSWVG
                     LILPDDHKGNKILSDYREEMERQRVCIAFVKMIPATWTSYFPRFWENMNETNVIIIHG
                     DIDSLESLLRNIGQRLLTRNVWVMNIERHVTEFSDYFMLDSFHGSLIFKHNYREKFEF
                     TKFIQTVNPNRYPEDIYLPKLWNLLFKCSFSDRNCQVLDNCQTNASLDILPSHIFDVA
                     MSEESISIYNGVYAVAHSLHDMRLHQVQMRPYENGEGMIFIPWQLNTFLKDLEVRDNR
                     SLNWIQTIDAEYDILNLWNLPKGLGLKVKIGSFSANAPKGQQLSLSEQIIQWPEIFSK
                     VPQSVCSESCGPGFRKVTLEGKPICCYKCTPCAENEISNETDSDQCVRCPESHYPNTE
                     KSNCYQKTSSFLAFEEPLGMALASIALCLSALTAFVIGIFVKYRDTPIVKANNQALSY
                     ILLITLKFCFLCSLNFIGQPNTAACILQQTTFGVAFTVALATVLAKAITVVLAFKVSF
                     PGRMVRWLMISRGPYYIVPICTLIQLLLCGIWMTMSPPFIDQDPHTEHGHIIILCNKG
                     SSLAFHAVLGYLCLLALGSYTMAFLSRNLPDTFNESKFLSLSMLVFFCVWVTFLPVYY
                     STKGKVMVAMEVFSILASSTALLAFIFGPKCYIILLRPDKNSFNHVRKKAHFRRKNSP
                     KI"
     misc_feature    127..1506
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    127..1506
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(232..234,526..531,1186..1188)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(232..234,526..531,1186..1188)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(346..348,355..357,487..489,748..750)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(346..348,355..357,487..489,748..750)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1528..1689
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1528..1689
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1747..2502
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..2502
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..221
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
     exon            222..516
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1308
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1524
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1648
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2577
                     /gene="Vom2r10"
                     /gene_synonym="RGD1565464"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgttct cctggatttt tatcttctgg ctcttgcaga ttctcaaatt tgtctctgct
       61 attgtcttta atatcagtag gtgttattac ataatcactg aagaatttca ccatgaagga
      121 gatattgtga ttggtgcatt tttcccactt catactttct atactgggaa gaaaatgcca
      181 gacccaactc taccatatca atatttggac aactacatac agtataactt tagaaactat
      241 cagtatattc tggctctgct atttgccatt gaggagatca atgggaaccc caatctttta
      301 cccaacatat ctcttggatt tgatttctac aatgtcagat tcactgaaaa ggaaacactt
      361 atgaatgctg ttatttggct cactgctcat gtgcagagaa aggttttacc taattacaat
      421 tgtaaaaaga aaaaattttc tgctgcactc acaggaacat catggactac atctgcccaa
      481 attgggacat tgcttcaact ctttaaattt ccacagatta cttttggacc ttatgatcct
      541 ctcttgagtg accatggtca gtattcttct ctctaccaga tggcccccaa ggacacatct
      601 ctttcccttg ccattgtttc tttaatggta tattttagat ggtcatgggt cggtctcatc
      661 ctccctgatg accacaaagg aaataaaatt ctatcagatt atagagagga aatggagcga
      721 caaagagtct gcattgcttt tgtaaaaatg atcccagcca catggacttc atattttcca
      781 aggttctggg aaaatatgaa tgagacaaat gtaataatta ttcatggtga cattgattct
      841 ctagaaagtc tattgcggaa tattgggcaa agattactga caaggaatgt ctgggttatg
      901 aacattgaac gccatgttac tgaatttagt gattatttca tgttagactc attccatgga
      961 agcctaattt ttaagcacaa ttatagagag aagtttgagt ttaccaaatt cattcaaaca
     1021 gttaatccta atcgataccc agaagacatt tatcttccga agttgtggaa tttgttattc
     1081 aagtgctcat tttctgatcg taattgtcaa gttttggaca attgccaaac caatgcttct
     1141 ttggatatat tacctagtca catatttgat gtagctatga gtgaagagag cattagtatt
     1201 tacaatggtg tgtatgctgt ggctcacagc ctccatgata tgagacttca tcaagttcaa
     1261 atgcgaccat atgaaaatgg cgaaggaatg atcttcattc catggcagct taacactttc
     1321 ctgaaggacc ttgaggtgag agacaacagg agtttaaatt ggatacagac aatagatgca
     1381 gaatatgaca ttcttaacct ttggaattta ccaaagggtc ttggactaaa agtgaaaata
     1441 ggatcctttt ctgcaaatgc tcccaagggt caacagttgt ctttatctga acagattatt
     1501 caatggccag aaatattttc aaaggtcccc cagtctgtgt gcagtgagag ttgtgggcct
     1561 ggattcagga aagtaaccct agagggcaag cccatctgct gctacaagtg cactccttgt
     1621 gcagaaaatg agatttctaa tgagacagat tctgaccagt gtgtgaggtg tccagaaagt
     1681 cattatccaa atacagagaa gagcaactgc taccaaaaaa cttcgagctt tctggccttt
     1741 gaagaaccct tggggatggc actagccagc atagctttgt gtttatctgc acttacagct
     1801 tttgttatag ggatctttgt gaaatacaga gacactccca ttgtcaaggc caataatcaa
     1861 gctctgagtt acattttgct catcacactc aaattctgtt ttctatgttc tttgaatttc
     1921 attggtcagc ccaacacagc tgcctgcatc cttcagcaga ccacttttgg agttgcattc
     1981 actgtggctc ttgccactgt gttagccaaa gctattactg tggttcttgc ctttaaggtc
     2041 agttttccag gaagaatggt aaggtggcta atgatatcaa ggggtccata ctacattgtt
     2101 cctatctgca ccctgatcca acttcttctt tgtggaatat ggatgacaat gtcaccacca
     2161 ttcattgacc aagatcctca tactgaacat ggacacatca tcattttgtg caacaagggt
     2221 tcatctcttg ctttccacgc tgtactggga tacctctgtc tcttggccct gggaagttat
     2281 accatggcct ttttgtctag aaatttgcct gatacattca atgaatcgaa atttctgtca
     2341 ttaagtatgc tagtgttctt ctgtgtctgg gtcacctttc ttcctgtcta ctacagcact
     2401 aaagggaagg tcatggtggc tatggaagta ttctctatct tggcttccag tacagcactc
     2461 cttgccttca tatttggtcc caagtgttac attatcttgt tgagaccaga caagaattct
     2521 tttaatcatg taaggaaaaa agcacatttt agacggaaga attctcctaa aatatag
//
LOCUS       NM_001191970            4938 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus thrombospondin type 1 domain containing 7A
            (Thsd7a), mRNA.
ACCESSION   NM_001191970 XM_575387
VERSION     NM_001191970.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4938)
  AUTHORS   Aktepe,O.H., Sahin,T.K., Guner,G., Guven,D.C., Yeter,H.H.,
            Kurtulan,O., Ozercan,I.H., Dizdar,O. and Yalcin,S.
  TITLE     Correlation Between THSD7A Expression and Tumor Characteristics of
            Azoxymethane-Induced Colon Cancer Model in Rats
  JOURNAL   Turk J Gastroenterol 32 (12), 1049-1056 (2021)
   PUBMED   34876395
  REMARK    GeneRIF: Correlation Between THSD7A Expression and Tumor
            Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.
REFERENCE   2  (bases 1 to 4938)
  AUTHORS   Tomas,N.M., Hoxha,E., Reinicke,A.T., Fester,L., Helmchen,U.,
            Gerth,J., Bachmann,F., Budde,K., Koch-Nolte,F., Zahner,G., Rune,G.,
            Lambeau,G., Meyer-Schwesinger,C. and Stahl,R.A.
  TITLE     Autoantibodies against thrombospondin type 1 domain-containing 7A
            induce membranous nephropathy
  JOURNAL   J Clin Invest 126 (7), 2519-2532 (2016)
   PUBMED   27214550
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001191970.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000004.1  41865368-41865524   c
            158-989             JAXUCZ010000004.1  41685319-41686150   c
            990-1238            JAXUCZ010000004.1  41635476-41635724   c
            1239-1420           JAXUCZ010000004.1  41632764-41632945   c
            1421-1576           JAXUCZ010000004.1  41603649-41603804   c
            1577-1789           JAXUCZ010000004.1  41600875-41601087   c
            1790-1984           JAXUCZ010000004.1  41521980-41522174   c
            1985-2219           JAXUCZ010000004.1  41512484-41512718   c
            2220-2335           JAXUCZ010000004.1  41508779-41508894   c
            2336-2468           JAXUCZ010000004.1  41501296-41501428   c
            2469-2572           JAXUCZ010000004.1  41500064-41500167   c
            2573-2767           JAXUCZ010000004.1  41486222-41486416   c
            2768-3031           JAXUCZ010000004.1  41484675-41484938   c
            3032-3210           JAXUCZ010000004.1  41468412-41468590   c
            3211-3216           JAXUCZ010000004.1  41466153-41466158   c
            3217-3350           JAXUCZ010000004.1  41464615-41464748   c
            3351-3504           JAXUCZ010000004.1  41460104-41460257   c
            3505-3649           JAXUCZ010000004.1  41456542-41456686   c
            3650-3765           JAXUCZ010000004.1  41455201-41455316   c
            3766-3883           JAXUCZ010000004.1  41445635-41445752   c
            3884-4029           JAXUCZ010000004.1  41445253-41445398   c
            4030-4204           JAXUCZ010000004.1  41444677-41444851   c
            4205-4378           JAXUCZ010000004.1  41442340-41442513   c
            4379-4474           JAXUCZ010000004.1  41434710-41434805   c
            4475-4557           JAXUCZ010000004.1  41431922-41432004   c
            4558-4765           JAXUCZ010000004.1  41430470-41430677   c
            4766-4852           JAXUCZ010000004.1  41428048-41428134   c
            4853-4937           JAXUCZ010000004.1  41427276-41427360   c
FEATURES             Location/Qualifiers
     source          1..4938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..4938
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="thrombospondin type 1 domain containing 7A"
                     /db_xref="GeneID:500032"
                     /db_xref="RGD:1566201"
     CDS             1..4938
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="thrombospondin type-1 domain-containing protein 7A;
                     thrombospondin, type I, domain containing 7A"
                     /codon_start=1
                     /product="thrombospondin type-1 domain-containing protein
                     7A precursor"
                     /protein_id="NP_001178899.2"
                     /db_xref="GeneID:500032"
                     /db_xref="RGD:1566201"
                     /translation="MGLRAGRLASLSRGVLQLMRLPLLLLLLLSSGARGAAAQGDTEV
                     PTLYLWKTGPWGRCMGDDCGPGGIQTRAVWCAHSEGWTTLHTNCKQAVRPSNQQNCFK
                     VCDWHKELYDWRLGPWNQCQPVISKSLEKARECVKGEEGIQVREITCIQKDKDIPAED
                     IICEYFEPKPLLEQACLIPCQQDCIVSEFSSWSECSRTCGSGLQHRTRHVVAPPQFGG
                     SGCPNLTEFQVCQSNPCEAEESMYSLQVGPWSACSVPHSRQARQARRRGKNKEREKER
                     GKAVKDPEARELIKKKRNRNRQNRQENRYWDIQIGYQTRDVMCLNRTGKSADLSFCQQ
                     ERLPMTFQSCVITKECQVSEWSEWSPCSKTCHDVTSPTGTRVRTRTIRQFPIGSEKEC
                     PELEEKEPCLSQGDGAVLCATYGWRTTEWTECHVDPLLSQQDKRRANQTALCGGGVQT
                     REIYCIQTNDILLSHINTQKDKEASKPVDSKLCTGPVPNTTQLCHVPCPIECEVSPWS
                     AWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGATGNCPHLLEAIPCEEPSCYDWK
                     SVRLGDCEPDNGKACGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDC
                     VLSAWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHP
                     CTVYHWQTGPWGQCIEDTSVSSFNTTTTWTGETSCSVGMQTRKVICVRVNVGQVGPKK
                     CPESLRPETVRPCLLPCRKDCIMTPYSDWTPCPSSCREGDSGARKQSRQRVIIQLPAY
                     GGRECSDPLYEEKACEAPPTCHSYRWKTHKWRRCQLVPWSIQQDVPGAQEGCGPGRQA
                     RAITCRKQDGGQASIQECLQYAGPVPALTQACQIPCQDDCQFTSWSKFSSCNGDCGAV
                     RTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLL
                     GVKVQGDNKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEW
                     SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYIW
                     VTEPWSVCKVTFVDMRDNCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEDMPLGSRE
                     CKLPCPEDCVISEWGPWTQCSLPCNPSGSRQRSADPIRQPADEGRACPDAVEKEPCNL
                     NKNCYRYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEELGLEKNW
                     QMNSSCTVECPLNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMEQ
                     SKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKAVDEEFCA
                     NIELIIDGNKQIVLEETCTQPCPGDCYLNDWSSWSLCQLTCVNGEDLGFGGIQVRSRA
                     VIIQELENQHLCPEQILETKSCDDGQCYEYKWMASAWKGSSRTVWCQRSDGVNVTGGC
                     LVVSQPDADRSCNPPCSQPHSYCSEMKACRCEEGYTEVMSSNSTLEQCTLIPVVVIPT
                     VEDKRDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLVFI
                     VSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM"
     sig_peptide     1..105
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    550..705
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    550..705
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    1048..1203
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    1048..1203
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    1504..1686
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    1504..1686
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    1870..2049
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    1870..2049
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    2062..2268
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2062..2268
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3073..>3195
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    3073..>3195
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    3262..3450
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3262..3450
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3463..3618
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    3463..3618
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    3826..3987
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    3826..3987
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     pfam19028"
                     /db_xref="CDD:465948"
     misc_feature    4210..4389
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     misc_feature    4210..4389
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /note="Spondin-like TSP1 domain; Region: TSP1_spondin;
                     cl46269"
                     /db_xref="CDD:480609"
     exon            1..157
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            158..989
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1238
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1420
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1576
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1789
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1984
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2219
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2335
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2468
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2572
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2767
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..3031
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3210
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3216
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3350
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3504
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3649
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3765
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3883
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4029
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4204
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4378
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4474
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4557
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4765
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4766..4853
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..4938
                     /gene="Thsd7a"
                     /gene_synonym="RGD1566201"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggctgc gagccgggcg cctggcgtcc ctgagccggg gcgtcctgca gctgatgcgg
       61 ctgccactgc tcctgctact cctgctgagc tctggagccc gcggggctgc ggcgcaggga
      121 gacacagagg tgcccaccct ctatctgtgg aagacgggtc cctggggacg gtgtatggga
      181 gatgactgtg gaccgggcgg catccagact cgggctgtgt ggtgcgctca ttcggaaggc
      241 tggacaacgt tacatacgaa ctgcaagcag gctgtgagac ccagtaacca gcaaaactgc
      301 ttcaaagtgt gtgactggca caaagagttg tacgactgga ggctgggacc ctggaatcag
      361 tgtcagcctg tgatttcaaa aagcctcgag aaagcacgag aatgtgtgaa gggggaggaa
      421 ggcatccagg tgagagagat aacgtgcatc cagaaggaca aggacattcc cgcagaggac
      481 atcatctgcg agtactttga acccaagccc ctcctggaac aggcctgcct catcccttgt
      541 cagcaagact gcatcgtgtc tgagttctcg tcctggtctg agtgctccag gacctgtggc
      601 agcggcctgc agcaccgcac taggcacgtg gtcgcaccac cacagtttgg aggctctggc
      661 tgtcccaacc tcactgagtt ccaggtatgc cagtccaacc cctgtgaggc agaggagagt
      721 atgtatagct tgcaggtagg gccctggagc gcatgctcag taccacactc acgtcaagcc
      781 aggcaagcca ggcgtcgtgg caaaaacaag gagagagaga aggagagagg aaaagctgtg
      841 aaggatccag aggcccgtga gctcatcaag aagaagagaa acagaaacag acaaaacaga
      901 caggagaaca gatactggga catccagatt gggtaccaga ccagggacgt gatgtgctta
      961 aacaggactg ggaagtctgc ggacctcagc ttttgccaac aagagagact gcccatgacc
     1021 ttccagtcct gtgtgatcac caaagagtgc caggtgtctg agtggtcgga gtggagcccg
     1081 tgttcaaaaa catgccacga tgtcacatct cctacaggca ctcgagtaag gacaaggacc
     1141 atcaggcagt ttccaattgg aagtgagaag gaatgtccgg aacttgagga gaaagagccc
     1201 tgtttgtctc aaggagatgg agctgtcctc tgtgctacgt atggctggag aactacagaa
     1261 tggacagagt gccacgtgga ccctttgctt agtcagcagg acaagaggcg tgccaaccag
     1321 acagccctct gtgggggtgg tgtccagacc cgggaaatat actgcataca gaccaacgac
     1381 atcttgctct cccatataaa tacacagaag gacaaagaag cttcaaaacc agtggactca
     1441 aaattatgca ctggtcctgt tcctaacacc acacagttgt gccacgttcc ttgtccaatt
     1501 gaatgtgagg tttcaccttg gtctgcctgg ggaccatgta cttatgaaaa ttgtaatgac
     1561 cagcaaggca aaaaaggatt caaattaagg aagcggcgca ttactaatga gcctactgga
     1621 ggttctgggg caactggaaa ctgccctcac ttattggaag ccattccctg tgaagagcca
     1681 tcctgctatg actggaaatc ggtgagactc ggagactgtg aaccagataa tggaaaagcc
     1741 tgtgggcccg gcactcaagt tcaagaggtt gtatgcatca acagtgatgg agaagaagtg
     1801 gacagacagc tatgccgaga tgcaatcttt cctatccctg tggcctgtga tgccccatgc
     1861 ccgaaggact gtgtgctcag tgcatggtcc acgtggtcct cctgttcaca cacctgctct
     1921 gggaaaacca cagaaggaaa acagatccga gctcggtcca ttctggccta tgcaggagaa
     1981 gaaggtggaa ttcgctgccc taacagcagt gctttgcaag aggtgcgcag ctgcaatgag
     2041 catccttgca ctgtgtacca ctggcaaact ggtccctggg gtcagtgtat agaggacaca
     2101 tcagtgtcat ccttcaatac aaccacaaca tggactgggg agacgtcatg ttctgtgggc
     2161 atgcagaccc ggaaagtcat ctgcgtgcga gtcaacgtgg gccaagtggg acccaagaag
     2221 tgtcctgaaa gccttcggcc tgaaacagtg agaccttgct tgcttccttg taggaaggat
     2281 tgtattatga ccccatacag tgactggaca ccatgtccct cttcatgcag agaaggggac
     2341 tctggagcca ggaagcagtc tcgacagcgc gtcatcattc agctgccagc ctatggaggc
     2401 agggaatgct cagacccact ctatgaagaa aaggcctgcg aggcccctcc cacatgtcac
     2461 agctacaggt ggaagacaca caaatggcgc cggtgccagt tagtcccttg gagcattcaa
     2521 caggatgtcc ctggagcaca ggaaggctgc gggcctggac ggcaggcaag agccattact
     2581 tgtcgaaagc aagatggagg gcaggctagc atccaggagt gcctccagta tgcaggccct
     2641 gtgccagccc tgacccaggc ttgccagatc ccctgccaag atgactgtca atttaccagc
     2701 tggtccaagt tttcttcatg caacggagac tgcggtgcag ttaggaccag aaagcgtgct
     2761 attgttggaa aaagtaaaaa gaaagaaaaa tgtaaaaact cccatctgta ccctctgatc
     2821 gagacccagt attgtccttg tgacaaatac aatgcacagc cagtggggaa ctggtcagac
     2881 tgcattttgc cggaagggaa ggctgaggtg ttgttgggag tgaaggtaca aggcgacaac
     2941 aaggaatgtg gacaaggata ccgttaccag gcgatggcgt gctacgatca aaatggcaga
     3001 cttgttgaaa catcgcgatg caacagccat ggttacatag aagaagcctg catcatcccc
     3061 tgcccctccg actgcaagct cagtgaatgg tctaactggt cccgctgcag taagtcctgt
     3121 ggcagcggtg tgaaggtccg gtccaagtgg ctgcgggaaa agccttataa cggaggaagg
     3181 ccttgcccca aactagacca tgtcaaccag gcgcaggtgt atgaggtcgt cccgtgccac
     3241 agtgactgca accagtacat atgggtcaca gagccatgga gtgtctgcaa ggtgaccttc
     3301 gtggacatgc gagacaactg tggagagggt gtgcagaccc gaaaagtaag gtgcatgcag
     3361 aatacagcag atggcccttc tgaacatgtg gaagactacc tgtgtgaccc agaggatatg
     3421 cccctgggct ctagagaatg taaactacca tgccctgagg actgtgtgat atccgagtgg
     3481 gggccatgga cccagtgttc tttgccttgc aatccaagtg gttcgaggca aaggtcagca
     3541 gatcccatca gacagcccgc tgatgaagga agagcgtgcc ctgatgctgt ggagaaagag
     3601 ccctgtaacc tgaacaaaaa ctgctaccgc tatgactata atgtcacaga ctggagtaca
     3661 tgtcagctaa gtgagaaggc ggtctgtggg aacggcatta aaacaaggat gttggactgt
     3721 gttcgaagtg atggcaagtc cgttgaccta aagtactgtg aagagcttgg gctggaaaag
     3781 aactggcaaa tgaacagttc ctgcacagtg gaatgccctt tgaactgtca gctttctgac
     3841 tggtctcctt ggtcagaatg ttcgcaaaca tgtggactca caggaaaaat gatacgaaga
     3901 cgaaccgtaa cccagccctt tcaaggtgat gggaggccct gcccttctct gatggaacaa
     3961 tccaagcctt gcccagtgaa gccatgctac cggtggcaat atggccagtg gtctccatgc
     4021 caagttcagg aggcccagtg tggagaagga accaggacac ggaatatttc ttgtgtcgtg
     4081 agtgatggct cagctgatga cttcagcaaa gcggtggatg aagagttctg tgctaacatc
     4141 gagctcatca tagatggtaa taaacaaata gttctggagg aaacctgcac ccagccctgc
     4201 ccaggtgact gttatttgaa tgactggtct tcatggagtc tgtgtcagct gacctgtgtg
     4261 aatggtgagg atcttggctt tggtggaata caggtccgat ccagagcagt gattatacaa
     4321 gaactggaga atcaacacct gtgcccagag cagatattag aaacaaaatc atgtgatgat
     4381 ggacaatgct atgaatacaa gtggatggca agtgcttgga agggctcttc tcgaacagtc
     4441 tggtgtcaaa ggtcagatgg tgtaaatgta acaggaggct gcttggtggt gagccagcct
     4501 gatgctgaca ggtcttgtaa cccaccctgt agtcaacccc actcatactg tagtgagatg
     4561 aaggcatgcc gctgtgaaga agggtacact gaagtcatgt cctctaatag cacccttgag
     4621 caatgcacac ttatccctgt ggtggtgatt cccactgtgg aagataaaag agatgtgaaa
     4681 accagtcggg cagttcaccc aacgcaaccc tccagtaacc cagcaggacg gggcaggaca
     4741 tggtttctac agccatttgg gccagatggg agactaaaga cctgggttta tggtgtcgca
     4801 gctggggcat ttgtgctgtt agtcttcatt gtctccatga tttatctagc gtgcaaaaag
     4861 ccaaagaaac cccaaagacg gcagaacaac cgcctcaaac ctttaacctt agcatatgat
     4921 ggagacgcgg acatgtaa
//
LOCUS       NM_001106796             843 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus homeo box C12 (Hoxc12), mRNA.
ACCESSION   NM_001106796 XM_001068476 XM_235696
VERSION     NM_001106796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 843)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068476.1, XM_235696.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..843
                     /gene="Hoxc12"
                     /note="homeo box C12"
                     /db_xref="GeneID:300262"
                     /db_xref="RGD:1310539"
     CDS             1..843
                     /gene="Hoxc12"
                     /codon_start=1
                     /product="homeobox protein Hox-C12"
                     /protein_id="NP_001100266.1"
                     /db_xref="GeneID:300262"
                     /db_xref="RGD:1310539"
                     /translation="MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLSY
                     PRRDNVCSLPWPSAEPCNGYPQPYLGSPVSLNPPFGRTCELARVEDSKGYYREPCAEG
                     GGGGLKREERGREPGAGPGAALLQLEPSGPPALGFKYDYPAGGGGGDGNTGPPHDPPS
                     CQSLESDSSSSLLNEGNKGASAGDPGSLVSPLNPGGGLSASGAPWYPIHSRSRKKRKP
                     YSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQA
                     LSFF"
     misc_feature    637..807
                     /gene="Hoxc12"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    637..807
                     /gene="Hoxc12"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            1..604
                     /gene="Hoxc12"
                     /inference="alignment:Splign:2.1.0"
     exon            605..843
                     /gene="Hoxc12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcgagc ataatctcct gaatcctggg tttgtggggc cgctggtgaa tatccacacg
       61 ggagacacct tctacttccc caacttccgc gcgtcagggg cgcaactccc ggggctgcct
      121 tcgctgtcct acccacgccg cgataacgtg tgctcgctgc cctggccgtc ggccgagccg
      181 tgcaatggct acccgcagcc ctatctcggc agtccggtgt ctctcaaccc gccttttggc
      241 cgcacgtgcg agttggctcg cgtggaggat agcaagggtt actaccgaga gccctgcgct
      301 gagggcggcg gcgggggcct aaagcgggag gagcgcgggc gcgaacccgg agcgggaccc
      361 ggggcagcgc tgctgcagct ggagccgtcg gggccacctg cgctcggctt caagtacgac
      421 tacccagcgg gcggcggcgg tggcgacggc aacacgggac ccccccacga cccaccctcg
      481 tgtcagtcat tggaatctga ctccagttca tccctactca acgagggcaa taagggcgcc
      541 agtgctggcg accctggctc tctggtatct ccgttgaacc caggcggcgg gctctcagcc
      601 agcggcgcgc cctggtaccc gatccacagc cgctcgcgaa agaagcgcaa gccgtattcg
      661 aagttgcagc tggctgagct ggagggcgag tttctggtca acgagttcat cacacgccag
      721 cgtcggaggg aactctcgga ccgcttgaat cttagtgatc agcaggtcaa gatttggttc
      781 cagaaccgga gaatgaaaaa gaaaagactt ctgctgagag agcaagctct ctccttcttc
      841 tag
//
LOCUS       NM_001409240             987 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mas-related G-protein coupled receptor member
            B8-like (LOC120093062), mRNA.
ACCESSION   NM_001409240 XM_039096211
VERSION     NM_001409240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Jul 12, 2022 this sequence version replaced XM_039096211.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-987               JAXUCZ010000001.1  107194132-107195118 c
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..987
                     /gene="LOC120093062"
                     /note="mas-related G-protein coupled receptor member
                     B8-like"
                     /db_xref="GeneID:120093062"
                     /db_xref="RGD:41298225"
     CDS             1..987
                     /gene="LOC120093062"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B8-like"
                     /protein_id="NP_001396169.1"
                     /db_xref="GeneID:120093062"
                     /db_xref="RGD:41298225"
                     /translation="MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFG
                     LAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIP
                     LLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLL
                     SLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPV
                     TKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCAN
                     PIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQSSIP"
     misc_feature    91..924
                     /gene="LOC120093062"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    91..924
                     /gene="LOC120093062"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="LOC120093062"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="LOC120093062"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    190..273
                     /gene="LOC120093062"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    190..273
                     /gene="LOC120093062"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="LOC120093062"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="LOC120093062"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="LOC120093062"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="LOC120093062"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    430..492
                     /gene="LOC120093062"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    430..492
                     /gene="LOC120093062"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    559..636
                     /gene="LOC120093062"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    559..636
                     /gene="LOC120093062"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="LOC120093062"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="LOC120093062"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    775..852
                     /gene="LOC120093062"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    775..852
                     /gene="LOC120093062"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     exon            1..987
                     /gene="LOC120093062"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactcaa gcatcccaga cccggaggct gacctcatcc aactgaatgg aagctaccac
       61 acagaaactt caccttgtgt catcgagtcc cgagtcatga ttttgctttc catcatcatt
      121 gccttctttg gcctggcagg aaatgccatg gttctgtggc ttctggcttt ccgcatgcgc
      181 aggaatgtct tctctgtcta catcctcaac ctggctgggg caaacttcct cttcctctgc
      241 actcacactg cattttccct ggaaaagatc attgtccttt ttcactccgt tcacatccac
      301 atcccattgt tgttctacac tctgtccaca cttgcttacc ttgcaggtgt gagcatggtc
      361 acagccatta gtgctgagta ctggttgtct ggcatttggc cctattggta tcagggccag
      421 cgcctaaaac acacaacaac tgtcatttgt actgggctct ggggtttggc cctgctcttg
      481 agcctcctgg aaggaaaaag ttgtggattc ctgggtagta cttataacca agatgtgtgt
      541 tggaaacttg atttcatcat agttgcatgg ttacttgttt tatttgctgt tctttctcga
      601 tccattcaag tcctactggt caggatcttc tgcggttcac agcggactcc tgtgaccaag
      661 ctgcatgtga ccattgtgct cacagcactg gtcttggtga tctgtggctt tcccttcgga
      721 attatcttct acctcttata ctggactaca gaagtttatt atattatgcc ttgtaattct
      781 ttccatgaga caattctcct cctgtcctac attaacagct gtgccaaccc catcatttgc
      841 ttacttgttg gctcaattag gcactgtaga ttccagtgtg ggactctcag gctgctactg
      901 cacagagcca tgcaagatat ccctgaggaa gaaggtgaag aacttgaaga agttgtagga
      961 gaacgagtac agagcagtat accctag
//
LOCUS       NM_001099463            2577 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 7 (Vom2r7), mRNA.
ACCESSION   NM_001099463 XM_001064298
VERSION     NM_001099463.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2577)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Aug 18, 2007 this sequence version replaced XM_001064298.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000001.1  58428784-58429004
            222-516             JAXUCZ010000001.1  58441019-58441313
            517-1308            JAXUCZ010000001.1  58441626-58442417
            1309-1524           JAXUCZ010000001.1  58443015-58443230
            1525-1648           JAXUCZ010000001.1  58444766-58444889
            1649-2577           JAXUCZ010000001.1  58456728-58457656
FEATURES             Location/Qualifiers
     source          1..2577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2577
                     /gene="Vom2r7"
                     /note="vomeronasal 2 receptor, 7"
                     /db_xref="GeneID:685557"
                     /db_xref="RGD:1592591"
     CDS             1..2577
                     /gene="Vom2r7"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 7"
                     /protein_id="NP_001092933.1"
                     /db_xref="GeneID:685557"
                     /db_xref="RGD:1592591"
                     /translation="MFYWIFISWFLQIPKFVSSFMTVNISLCFYKTPEDFHYEGDVVI
                     GAFFPIHTYYSPNKVPHKTVPYQYMDNYLQYNFKNYQYILALVLAIEEINGNPNLLPN
                     ISLGFDFYNIRFTEKETLMNACIWITGQGQKKILPNYNCNKRVFTAALTGTSWTASAQ
                     IGTLLQLFKFPQLSFGPYDPILSDRGQYSSLYQMTPKYTSLSQGIVSLMVHFRWSWVG
                     IILPDDHKGNKILSEFRENMEKKGVCIAFVKIIPFTWTKYFNKFWENMDETNVIIIYS
                     DIDSITGIMRNIGQRLLTWKVWVMNIEPHITDYADYFMLDSFHGSLIFTHHFKESFEL
                     TKFIQTVNPYKYPEDIYLPKLWHLFFKCSFSDIDCQLLANCQSNASLDVLPSHILDMA
                     ISEESNTIYNAVYAVAHSLHQMTLQQVEIQPQENGEVMTFFPWQLNIFLKDIDKRDNM
                     SLGGRKKLNAEYDIFNLWNLPKGLGRKVKIGSFSGNAPEGQQLSLSEPMIQWAERFSE
                     IPQSVCSKSCMPGFRKVTLEGKAICCYNCTPCADNEISNETDVDQCMKCPESHYANPE
                     KNHCFQKTVSFLAYEDPLGMILASISLCLSALTAFVIGVFVKYRETPIVKANNRGLSY
                     TLLITITFCLLCSLNFIGQPNAATCIFQQTIFGIAFTVALATVLAKAITVVIAFKATI
                     PGRMVRWLMISRAPNYIIPICTLIQLLLCAIWMATSPPFIDQDFHAEHGHILLLCNKG
                     SSLAFHCVLGYLCSLAIGGYTMAFLSRNLPDTFNESKFLSFSMLVFFCVWVTFLPVYH
                     STKGKVMVAMEVFSILASSAALLGFIFAPKCYIILLRPEKNSFHHMRDKTHSRKNKSI
                     KI"
     misc_feature    127..1506
                     /gene="Vom2r7"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    127..1506
                     /gene="Vom2r7"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1528..1689
                     /gene="Vom2r7"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1528..1689
                     /gene="Vom2r7"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1747..2502
                     /gene="Vom2r7"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..2502
                     /gene="Vom2r7"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1747..1824
                     /gene="Vom2r7"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r7"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1756..1758,1765..1770,1777..1782,1786..1791,
                     1891..1893,1903..1905,1912..1917,1939..1941,1951..1953)
                     /gene="Vom2r7"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1858..1923
                     /gene="Vom2r7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r7"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1918..1920,1954..1959,1966..1971,1978..1980,
                     2218..2220,2233..2235,2242..2247,2254..2256,2356..2358,
                     2365..2370,2377..2379,2389..2391,2413..2418,2425..2427,
                     2434..2436,2446..2448)
                     /gene="Vom2r7"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1948..2022
                     /gene="Vom2r7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2092..2142
                     /gene="Vom2r7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2221..2301
                     /gene="Vom2r7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2323..2394
                     /gene="Vom2r7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2407..2484
                     /gene="Vom2r7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..221
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
     exon            222..516
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1308
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1524
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1648
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2577
                     /gene="Vom2r7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttttact ggatctttat ttcctggttc ttacagattc ccaaatttgt ctcttccttt
       61 atgactgtga atatcagtct gtgcttttac aaaactcctg aagattttca ctatgaagga
      121 gacgttgtga taggtgcatt ttttcctatc catacttact attctccaaa caaagttcca
      181 cataaaactg taccatacca atatatggac aattatttac agtataattt taagaactac
      241 cagtatattc tggctttggt attggccatt gaggagataa atgggaaccc caatctttta
      301 cctaatatat ctcttggatt tgatttctac aatatcagat tcactgagaa agaaaccctt
      361 atgaatgctt gtatttggat cacaggtcaa ggacagaaaa agattttacc aaattacaat
      421 tgtaacaaaa gagtttttac tgctgcactt acagggacat catggacagc atctgcccaa
      481 attggaacat tacttcaact ctttaaattt ccacagcttt cttttggacc ttatgatccc
      541 attttgagtg atcgtggtca atattcttct ctgtatcaga tgacccctaa gtatacatct
      601 ctttcacaag gcattgtatc tttgatggtt cattttaggt ggtcctgggt tggtatcatc
      661 cttccagatg accacaaagg aaacaaaatt ttatcagagt tcagagaaaa tatggagaaa
      721 aaaggagtct gcatagcttt tgtgaaaata atcccattca catggactaa gtattttaac
      781 aaattctggg aaaatatgga tgagacaaat gtcataatta tttatagtga cattgattcc
      841 atcacaggta taatgcgaaa tattgggcaa agactgttga cgtggaaagt ctgggtcatg
      901 aacattgaac ctcatattac tgattatgct gattatttca tgcttgactc atttcatggt
      961 agccttattt ttacacacca ttttaaagag agttttgaac ttactaagtt tattcaaaca
     1021 gttaatcctt acaaatatcc agaagatatt taccttccta agttatggca tttgttcttc
     1081 aagtgctcat tttctgatat tgactgtcaa ctactggcta actgtcaatc caacgcgtct
     1141 ctggatgtat tacctagtca tatattggac atggcaatca gtgaagaaag caacactatc
     1201 tacaatgctg tgtatgctgt ggctcacagt ctccatcaga tgactcttca acaagtagaa
     1261 atacaaccac aggaaaatgg ggaagtgatg accttcttcc cctggcagct aaacattttc
     1321 ctaaaggaca ttgataagag agacaatatg agtttaggtg ggagaaagaa attaaatgca
     1381 gaatatgaca tttttaacct ttggaattta ccaaagggtc ttggtcgtaa agtgaaaata
     1441 ggatcctttt caggaaatgc tcctgagggc caacagttgt ccttatctga acctatgata
     1501 caatgggcag aaagattttc agagatccct cagtctgtat gtagtaagag ttgtatgcct
     1561 ggattcagaa aagtaaccct ggagggcaag gccatctgct gttacaattg cactccctgt
     1621 gcagacaatg agatttctaa tgagacagat gtggatcagt gtatgaagtg tccagagagt
     1681 cattatgcaa atccagagaa gaaccattgc ttccagaaaa ctgtgagctt tctggcctat
     1741 gaagacccct tggggatgat tctggctagt atatctctct gcttatctgc actcacagcc
     1801 tttgtaattg gggtctttgt gaagtacaga gagactccca ttgtgaaagc caataatcgt
     1861 ggtctcagtt acactttgct catcacaatc accttttgtt tactctgttc cttgaacttt
     1921 attggtcaac caaatgcagc cacctgtatt ttccagcaga ccatatttgg aattgcattc
     1981 actgtggctc tggctactgt attggccaaa gctattactg tggtcattgc tttcaaagcc
     2041 accattccag ggagaatggt gaggtggtta atgatatcaa gggccccaaa ctatataatt
     2101 cctatttgta ctctgatcca acttcttctt tgtgcaatat ggatggcaac ctctcctcca
     2161 ttcattgacc aagattttca tgctgaacat ggacacatcc tacttttgtg taacaaggga
     2221 tcatctcttg ccttccactg tgttctggga tacctctgct ccctggcaat tggtggttac
     2281 accatggcat tcttatctag aaatctgcct gatacgttca atgaatccaa atttctgtca
     2341 ttcagcatgc tggtgttctt ctgtgtctgg gtcacatttc ttcctgtcta ccatagcact
     2401 aaggggaagg tcatggtggc tatggaagta ttctctatct tagcttccag tgcagccctc
     2461 cttggtttta tatttgctcc taagtgttac attatcttgt tgagaccaga aaagaactca
     2521 tttcatcata tgagagacaa aacacattct agaaagaata agtctattaa aatatag
//
LOCUS       NM_001085381            1594 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus gap junction protein, gamma 1 (Gjc1), mRNA.
ACCESSION   NM_001085381 XM_001081521
VERSION     NM_001085381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Luetic,M., Kretzschmar,G., Grobe,M., Jercic,L., Bota,I., Ivic,V.,
            Balog,M., Zjalic,M., Vitlov Uljevic,M., Heffer,M., Gaspar,R.,
            Tabi,T., Vukojevic,K., Vari,S.G. and Filipovic,N.
  TITLE     Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet
  JOURNAL   Acta Histochem 123 (8), 151817 (2021)
   PUBMED   34808525
  REMARK    GeneRIF: Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet.
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Nagy,J.I. and Rash,J.E.
  TITLE     Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex:
            species-specific expression, compensation in Cx36 null mice and
            co-localization in neurons vs. glia
  JOURNAL   Eur J Neurosci 46 (2), 1790-1804 (2017)
   PUBMED   28561933
  REMARK    GeneRIF: Cx45-puncta in the cerebellar molecular layer were
            co-localized with Cx36-puncta and additionally occurred along
            Bergmann glial processes adjacent to Cx43-puncta. Expression of
            both Cx43 and Cx45 in Bergmann glia of rat may contribute to the
            complex properties of junctional coupling between these cells and
            perhaps to their reported coupling with Purkinje cells.
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Beheshti,S., Zeinali,R. and Esmaeili,A.
  TITLE     Rapid upregulation of the hippocampal connexins 36 and 45 mRNA
            levels during memory consolidation
  JOURNAL   Behav Brain Res 320, 85-90 (2017)
   PUBMED   27913256
  REMARK    GeneRIF: The results of the present study revealed that during
            memory consolidation in a passive avoidance paradigm, a rapid
            upregulation of Cx45 mRNAs level occurs in the hippocampus, which
            declines to the control level by 24 h after training.
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Guo,C.X., Tran,H., Green,C.R., Danesh-Meyer,H.V. and Acosta,M.L.
  TITLE     Gap junction proteins in the light-damaged albino rat
  JOURNAL   Mol Vis 20, 670-682 (2014)
   PUBMED   24883012
  REMARK    GeneRIF: Changes in connexins, including Cx36, Cx43, and Cx45, may
            contribute to the damage process.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Cea,L.A., Cisterna,B.A., Puebla,C., Frank,M., Figueroa,X.F.,
            Cardozo,C., Willecke,K., Latorre,R. and Saez,J.C.
  TITLE     De novo expression of connexin hemichannels in denervated fast
            skeletal muscles leads to atrophy
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16229-16234 (2013)
   PUBMED   24043768
  REMARK    GeneRIF: The absence of Cx43/Cx45 hemichannels in skeltal muscles
            cells greatly attenuates the inflammasome activation and muscle
            atrophy.
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Johnson,C.M., Kanter,E.M., Green,K.G., Laing,J.G., Betsuyaku,T.,
            Beyer,E.C., Steinberg,T.H., Saffitz,J.E. and Yamada,K.A.
  TITLE     Redistribution of connexin45 in gap junctions of
            connexin43-deficient hearts
  JOURNAL   Cardiovasc Res 53 (4), 921-935 (2002)
   PUBMED   11922902
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Li,X. and Simard,J.M.
  TITLE     Connexin45 gap junction channels in rat cerebral vascular smooth
            muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 281 (5), H1890-H1898 (2001)
   PUBMED   11668048
REFERENCE   8  (bases 1 to 1594)
  AUTHORS   Laing,J.G., Manley-Markowski,R.N., Koval,M., Civitelli,R. and
            Steinberg,T.H.
  TITLE     Connexin45 interacts with zonula occludens-1 in osteoblastic cells
  JOURNAL   Cell Commun Adhes 8 (4-6), 209-212 (2001)
   PUBMED   12064590
  REMARK    GeneRIF: data suggests that connexin 45 and ZO-1 directly interact
            in osteoblastic cells (ROS/Cx45) [ZO-1]
REFERENCE   9  (bases 1 to 1594)
  AUTHORS   Kruger,O., Plum,A., Kim,J.S., Winterhager,E., Maxeiner,S.,
            Hallas,G., Kirchhoff,S., Traub,O., Lamers,W.H. and Willecke,K.
  TITLE     Defective vascular development in connexin 45-deficient mice
  JOURNAL   Development 127 (19), 4179-4193 (2000)
   PUBMED   10976050
REFERENCE   10 (bases 1 to 1594)
  AUTHORS   Davis,L.M., Kanter,H.L., Beyer,E.C. and Saffitz,J.E.
  TITLE     Distinct gap junction protein phenotypes in cardiac tissues with
            disparate conduction properties
  JOURNAL   J Am Coll Cardiol 24 (4), 1124-1132 (1994)
   PUBMED   7930207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001085381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.41211.1,
                                           SRR26643299.45972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000010.1  88283931-88284237   c
            308-383             JAXUCZ010000010.1  88265846-88265921   c
            384-1594            JAXUCZ010000010.1  88263238-88264448   c
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="gap junction protein, gamma 1"
                     /db_xref="GeneID:266706"
                     /db_xref="RGD:628889"
     exon            1..307
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     exon            308..383
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    362..364
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="upstream in-frame stop codon"
     exon            384..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="gap junction channel protein connexin 45;
                     connexin-45; gap junction alpha-7 protein; gap junction
                     membrane channel protein alpha 7; connexin q"
                     /codon_start=1
                     /product="gap junction gamma-1 protein"
                     /protein_id="NP_001078850.1"
                     /db_xref="GeneID:266706"
                     /db_xref="RGD:628889"
                     /translation="MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIY
                     YDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM
                     EHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKP
                     KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKI
                     DCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYN
                     YPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPAD
                     LETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKT
                     SVWI"
     misc_feature    407..1168
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="Region: Connexin; pfam00029"
                     /db_xref="CDD:459638"
     misc_feature    407..1168
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="Region: Connexin; pfam00029"
                     /db_xref="CDD:459638"
     misc_feature    458..520
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     transmembrane region"
     misc_feature    629..691
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     transmembrane region"
     misc_feature    836..898
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    929..997
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     transmembrane region"
     misc_feature    1091..1153
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     transmembrane region"
     misc_feature    1472..1591
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 ttgttcttcg ttgactctcc agattgaaaa tagagaggag gcgctaatgc tgtgattggg
       61 ctggctgctg cgtttggatt ttcgagttga aaagatttac gtgacttgtg tttagaattt
      121 ggggtccttc ctccccgctt ttcggattat ttgggattgc ttttcttttt gcgaagtggg
      181 tgaatttggt tttttttgtc atttgaagtc atttttggtc ctcggggact ggcagcgcta
      241 cagatttcat tgtgctcgtg ctttattttt tttctcatcc acactgggtg ccatcgagga
      301 actcaagaga gaatttggga aagtaacaaa cacagcacag agtctgaaag gaggttttgg
      361 gtaacggagg ttctggttaa cagggcaaac caattccacc accatgagtt ggagcttcct
      421 gactcgcctg ctagaggaga tacacaacca ttcgacgttt gtagggaaga tctggctcac
      481 tgtgctgatt gtctttcgaa ttgtcctaac tgcggtagga ggagagtcca tctactatga
      541 tgagcaaagc aaatttgtgt gcaacacaga gcagccgggc tgtgagaacg tctgctatga
      601 tgcctttgcc ccgctctccc acgtgcgctt ctgggtattc cagatcatcc tggttgctac
      661 tccctctgtg atgtacctgg gatatgctat tcacaagatt gccaaaatgg agcacggcga
      721 ggcagacaag aaggcagctc ggagcaaacc ctatgccatg cgttggaagc agcaccgggc
      781 tctggaagaa acggaagagg accatgaaga ggatcctatg atgtacccag agatggagtt
      841 agaaagcgag aaagaaaata aagagcagag ccaaccaaaa cccaagcatg atggccgccg
      901 acgcattcgt gaggatgggc tcatgaaaat ctatgtgttg cagctgctag ccaggactgt
      961 gtttgaggtg ggctttctca tagggcagta tttcctgtat ggcttccaag tacacccatt
     1021 ttatgtgtgc agcagacttc cttgtcctca taagatagac tgctttattt ctagacccac
     1081 tgaaaagacc atcttccttc tgataatgta tggtgtcaca ggcctctgcc tattgcttaa
     1141 catttgggag atgcttcatc tagggtttgg gaccattcga gactcactaa acagtaaaag
     1201 gagggaactt gatgatccgg gtgcttataa ttatcctttc acttggaata caccatctgc
     1261 tcccccaggc tataacattg ctgtcaaacc agatcaaatc cagtacactg agttgtccaa
     1321 tgctaagatt gcctacaagc agaacaaagc caatatcgcc caggagcagc agtacggcag
     1381 ccacgaggag cacctcccgg ccgatctgga gaccctgcag cgggagatca gaatggccca
     1441 ggaacgcttg gatctagcaa tccaggccta ccatcaccag aacaaccccc atggtcctcg
     1501 ggaaaagaag gccaaagtgg ggtccaaatc tgggtccaac aaaagcagta ttagtagcaa
     1561 atcaggagat gggaagacct ccgtctggat ttaa
//
LOCUS       NM_001191641            1458 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 58 (Trim58), mRNA.
ACCESSION   NM_001191641 XM_220473
VERSION     NM_001191641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Thom,C.S., Traxler,E.A., Khandros,E., Nickas,J.M., Zhou,O.Y.,
            Lazarus,J.E., Silva,A.P., Prabhu,D., Yao,Y., Aribeana,C.,
            Fuchs,S.Y., Mackay,J.P., Holzbaur,E.L. and Weiss,M.J.
  TITLE     Trim58 degrades Dynein and regulates terminal erythropoiesis
  JOURNAL   Dev Cell 30 (6), 688-700 (2014)
   PUBMED   25241935
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XM_220473.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.13265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               JAXUCZ010000010.1  43523404-43523820
            418-513             JAXUCZ010000010.1  43525803-43525898
            514-744             JAXUCZ010000010.1  43528908-43529138
            745-767             JAXUCZ010000010.1  43529967-43529989
            768-868             JAXUCZ010000010.1  43530083-43530183
            869-1458            JAXUCZ010000010.1  43533830-43534419
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1458
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="tripartite motif-containing 58"
                     /db_xref="GeneID:303167"
                     /db_xref="RGD:1566174"
     CDS             1..1458
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 58"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM58"
                     /protein_id="NP_001178570.1"
                     /db_xref="GeneID:303167"
                     /db_xref="RGD:1566174"
                     /translation="MATAPGERLQEEARCSVCLDFLQEPISVDCGHSFCLRCISELCE
                     KSDSAQGVYACPQCRGPFRPSSFRPNRQLASLVDTVRQLGLGTGHAGSRQCSRHGEDL
                     SHFCEEDQAMVCWVCDTSPEHRSHRTEPLQEAASRYQRMLQVALELVKKEMEEALTQE
                     ANVGKKTIIWKEKVEMQRQRFRLEFEKHRGFLAQEEQLQLRRLEEEERATLQRLRDSR
                     NRLAQQNKALKELAEELEEMSQRPAVALLEGARGVLTRSEAMTRLEPEAVPMELKTVC
                     RIPGMREMLRKFQVDVKLDPATAHPSLLLTTDLRSVQDAEVWRDVPSNPERFDTWPCI
                     LGLQGFSSGRHYWEVIVGERAEWGLGVCQDSVLRKGETTPSPENGVWAMWLLRGSEYM
                     VLSSPSVPVFQDERPRRIGIFLDYEAGQISFYNVTNGSYIYTFNHLFSGVLRPYFFVC
                     DTTPLILPPMTEAGPGNWTSRGLLDFAVAARSEEY"
     misc_feature    31..186
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein TRIM58 and similar proteins;
                     Region: RING-HC_TRIM58_C-IV; cd16606"
                     /db_xref="CDD:438268"
     misc_feature    31..186
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein TRIM58 and similar proteins;
                     Region: RING-HC_TRIM58_C-IV; cd16606"
                     /db_xref="CDD:438268"
     misc_feature    271..402
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins TRIM39, TRIM58 and similar
                     proteins; Region: Bbox2_TRIM39-like; cd19780"
                     /db_xref="CDD:380838"
     misc_feature    271..402
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins TRIM39, TRIM58 and similar
                     proteins; Region: Bbox2_TRIM39-like; cd19780"
                     /db_xref="CDD:380838"
     misc_feature    <394..>672
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="Family of unknown function (DUF5401); Region:
                     DUF5401; pfam17380"
                     /db_xref="CDD:375164"
     misc_feature    <394..>672
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="Family of unknown function (DUF5401); Region:
                     DUF5401; pfam17380"
                     /db_xref="CDD:375164"
     misc_feature    871..1374
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     58 (TRIM58), also known as BIA2; Region: SPRY_PRY_TRIM58;
                     cd15816"
                     /db_xref="CDD:293988"
     misc_feature    871..1374
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     58 (TRIM58), also known as BIA2; Region: SPRY_PRY_TRIM58;
                     cd15816"
                     /db_xref="CDD:293988"
     exon            1..417
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
     exon            418..513
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
     exon            514..744
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
     exon            745..767
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
     exon            768..868
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1458
                     /gene="Trim58"
                     /gene_synonym="RGD1566174"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccacag cacccgggga gcggctgcag gaggaggcac ggtgctcagt gtgcctggac
       61 ttcctgcagg agcccatcag cgttgactgt ggtcacagct tctgtctgcg gtgcatatct
      121 gagctctgcg agaaatcgga cagcgctcag ggagtctatg cttgtcccca gtgcaggggt
      181 cccttcaggc cctccagctt cagacccaac cggcagctgg ccagcctggt ggacaccgtg
      241 cggcagctgg ggctgggcac cggacacgcg gggtcgcgtc agtgttcgag gcacggtgag
      301 gacctgagcc acttctgtga agaggaccaa gcgatggtgt gctgggtctg cgacaccagc
      361 cctgagcacc ggagccaccg cactgagccg ctgcaggagg cagccagccg ctaccagagg
      421 atgctccaag tggctttgga acttgtgaag aaggaaatgg aggaggctct gacccaggag
      481 gccaacgtgg gaaagaagac catcatctgg aaggagaaag tggagatgca gagacaacgt
      541 ttcaggctgg agtttgagaa acaccggggc tttctggccc aggaggagca gctgcagctg
      601 aggcgactgg aagaggagga gcgagcaacc ctgcagagac tgcgtgacag taggaacagg
      661 ctggcccaac agaacaaagc cctgaaggaa ctggctgaag agctggagga gatgagtcag
      721 aggccagcgg tagcactgct ggagggagcg agaggagtct tgacgcgaag cgaagctatg
      781 accaggctgg aaccagaggc tgtccctatg gagctgaaga ccgtgtgccg catccctggg
      841 atgagggaga tgctgaggaa gttccaagtg gacgtgaaac tcgatcccgc cactgcccac
      901 ccaagcttgc tcttaacgac ggatctgcgc agtgtgcagg atgcggaggt ctggagggat
      961 gtcccgagca accctgagcg ctttgacacc tggccctgca tcctgggcct gcagggcttc
     1021 tcctccggga ggcattactg ggaagtcatc gtgggggaaa gagcagagtg ggggctaggg
     1081 gtctgccaag actcagtgct tagaaaaggg gagaccacac cgtccccaga gaatggtgtc
     1141 tgggccatgt ggctcctgag ggggagcgag tacatggtcc tgtcctctcc ctcggtgcct
     1201 gtgttccaag atgagcgacc tcgtcgcatc gggatctttt tggactacga agccggccaa
     1261 atctccttct acaatgtcac aaatgggtct tacatctaca catttaacca tctcttctcc
     1321 ggtgttctca ggccctattt cttcgtctgt gacacaactc ctcttatctt gccacccatg
     1381 acagaagcag gacctggaaa ctggacttcc aggggtctcc ttgattttgc tgttgctgcc
     1441 agaagtgagg aatactaa
//
LOCUS       NM_001099461            2517 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 1 (Vom2r1), transcript
            variant 2, mRNA.
ACCESSION   NM_001099461 XM_001053213
VERSION     NM_001099461.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 15, 2021 this sequence version replaced NM_001099461.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  164474-164679
            207-477             JAXUCZ010000001.1  167337-167607
            478-1281            JAXUCZ010000001.1  168042-168845
            1282-1506           JAXUCZ010000001.1  169698-169922
            1507-1630           JAXUCZ010000001.1  171132-171255
            1631-2517           JAXUCZ010000001.1  174328-175214
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..2517
                     /gene="Vom2r1"
                     /note="vomeronasal 2 receptor, 1"
                     /db_xref="GeneID:678740"
                     /db_xref="RGD:1596944"
     CDS             1..2517
                     /gene="Vom2r1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; vomeronasal type-2 receptor 26-like"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 1 precursor isoform 2
                     precursor"
                     /protein_id="NP_001092931.2"
                     /db_xref="GeneID:678740"
                     /db_xref="RGD:1596944"
                     /translation="MKKLCAFTIAFFPLKFCLILCSLTEPNCFWRIKKIEVYDGDLQN
                     DCGFVLFTLESPIEENFYNHIINFRKYEFFLVMFFATDEINKNPYLLSNMSLIFSFIF
                     GMCEDTMGVLDKAYLHQNNYFDLLNYNCGRKKRCDVKLTGPSWKTSLKLSVNSRAPKI
                     FFGPFNPNLSDHDQFPYIYQIATKDTYLLHGMVSLMFHFEWTWIGLIITDDDQGIQFH
                     SDLREEMQRHAICLAFVIMIPESIKLYNTKFKIYDQQLMTSSAKVTIIYGKMISTLEL
                     NFARWTYLVARRIWITTSKLDVITYDKDFSLDFFHGTVIFAHHHNDIATFRNFMQIIN
                     TSKYPVDISQSMGQWNHFNCSISKNKKKMDFFMLKNPMEWLTQHTFDMVLSEEGYNLY
                     NAVYAVAHTYHELIFQQVESQEMAKPKGLFTDCQQVASLLKTRVFTNPVGELVNMNHK
                     ENQCAKYDIFIIWNFPNGLGLKVKIGSYFPCLQQSQHLHISEDWEWVTGETLVPSSVC
                     SETCTAGFRKSHQKQTANCCFDCVQCQENEIANDTADMEQCVRCPDDSYANLEQTQCL
                     QRAVTFLAYEDPLGMALGCMALSFSAITVLVLVTFVKYRDTPIVKANNRILSYILLIS
                     LVFCFLCSLLFIGHPNQATCILQQATFAIFFTVAISTVLAKTITVVTAFKLTTPGRRI
                     RKMMIKVATHLLIPICTLIQLVLCAIWLVTSPPFIDRDIQSEHGKVIIICNKGSVIAF
                     HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYHSTRGK
                     VMVIVEVFSILASSAGLLGCIFVQKCYVLLVRPDLNVLQK"
     sig_peptide     1..78
                     /gene="Vom2r1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    133..1488
                     /gene="Vom2r1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    133..1488
                     /gene="Vom2r1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1510..1674
                     /gene="Vom2r1"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1510..1674
                     /gene="Vom2r1"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1732..2487
                     /gene="Vom2r1"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1732..2487
                     /gene="Vom2r1"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1732..1809
                     /gene="Vom2r1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1732..1809
                     /gene="Vom2r1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1741..1743,1750..1755,1762..1767,1771..1776,
                     1876..1878,1888..1890,1897..1902,1924..1926,1936..1938)
                     /gene="Vom2r1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1741..1743,1750..1755,1762..1767,1771..1776,
                     1876..1878,1888..1890,1897..1902,1924..1926,1936..1938)
                     /gene="Vom2r1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1843..1908
                     /gene="Vom2r1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1843..1908
                     /gene="Vom2r1"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1903..1905,1939..1944,1951..1956,1963..1965,
                     2203..2205,2218..2220,2227..2232,2239..2241,2341..2343,
                     2350..2355,2362..2364,2374..2376,2398..2403,2410..2412,
                     2419..2421,2431..2433)
                     /gene="Vom2r1"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1903..1905,1939..1944,1951..1956,1963..1965,
                     2203..2205,2218..2220,2227..2232,2239..2241,2341..2343,
                     2350..2355,2362..2364,2374..2376,2398..2403,2410..2412,
                     2419..2421,2431..2433)
                     /gene="Vom2r1"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1933..2007
                     /gene="Vom2r1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1933..2007
                     /gene="Vom2r1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2077..2127
                     /gene="Vom2r1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2077..2127
                     /gene="Vom2r1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2206..2286
                     /gene="Vom2r1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2206..2286
                     /gene="Vom2r1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2308..2379
                     /gene="Vom2r1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2308..2379
                     /gene="Vom2r1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2392..2469
                     /gene="Vom2r1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2392..2469
                     /gene="Vom2r1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..477
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1281
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1506
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1630
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2517
                     /gene="Vom2r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaagc tgtgtgcttt cactattgcc ttttttcctc tgaagttttg tctcatcttg
       61 tgcagtttga ctgaacccaa ttgcttttgg aggataaaaa agatcgaagt ttatgatgga
      121 gatttgcaaa atgactgtgg ttttgtcctt tttacacttg agagccctat tgaagaaaat
      181 ttttataatc acattattaa ttttagaaaa tatgaatttt ttctggtaat gttttttgct
      241 actgatgaga tcaacaagaa tccttatctt ttatccaaca tgtctttgat attttccttc
      301 atttttggta tgtgtgaaga tacaatggga gttctggata aagcatattt acatcaaaac
      361 aactatttcg atctacttaa ttataactgt ggaagaaaga aacgttgtga tgtaaaactt
      421 acaggaccat catggaaaac ttccttaaaa ctttcagtta attcaagggc accaaagatt
      481 ttctttggac catttaatcc taacctgagt gaccatgacc agtttcccta tatctatcag
      541 atagcaacca aggacacata tttgctccat ggcatggtct ccttgatgtt tcattttgaa
      601 tggacttgga taggactgat catcacagat gatgaccaag gtattcagtt tcactcagac
      661 ttgagagaag aaatgcaaag gcatgcgatc tgtttagctt ttgtgattat gatcccagaa
      721 agcattaagt tatacaacac aaagtttaag atatatgacc aacaacttat gacatcttct
      781 gcaaaggtta ctatcattta tggcaaaatg atctccactc tagaactcaa ctttgcaaga
      841 tggacatatt tagttgcacg gagaatctgg atcacaacct caaaattgga tgtcatcaca
      901 tatgataaag atttcagcct tgatttcttc cacgggactg tcatttttgc ccaccaccac
      961 aatgacatcg ctacatttag aaattttatg caaataataa acacatccaa gtatccagta
     1021 gatatttctc agtctatggg gcagtggaat cattttaact gttcaatctc aaagaacaag
     1081 aagaaaatgg atttttttat gttgaaaaac ccaatggaat ggttaacaca gcacacattt
     1141 gacatggtcc tgagtgaaga aggttacaat ttgtataatg ctgtgtatgc tgtggcccac
     1201 acctatcacg aactcatttt tcaacaagta gagtctcagg aaatggccaa acccaaagga
     1261 ctattcactg actgtcagca ggtggcttct ttgcttaaaa ctagggtatt tactaaccct
     1321 gttggagagc tggtgaacat gaatcataag gaaaatcagt gtgccaagta tgacattttc
     1381 atcatttgga attttccaaa tggccttgga ttaaaagtga aaataggaag ctattttcct
     1441 tgtttgcaac agagtcaaca tcttcatata tctgaagact gggagtgggt tacaggagaa
     1501 acattggttc cctcctcagt gtgtagtgag acatgtactg caggattcag aaaaagtcat
     1561 cagaaacaaa cagccaactg ctgctttgat tgtgtccagt gccaagaaaa tgagattgcc
     1621 aatgatacag cagatatgga gcagtgtgtg cggtgtccag atgattcata tgccaactta
     1681 gaacaaaccc agtgcctcca aagagcggtg acgtttctcg cttatgaaga tccattgggg
     1741 atggctctag gctgcatggc cctgtccttt tcagccatca cagttctagt actagtcact
     1801 tttgtgaagt acagggatac acccattgtg aaagccaata accgtattct cagctacatc
     1861 ctgctcatat ctctagtctt ctgttttctc tgctcattgc tcttcattgg acatcccaac
     1921 caggccacct gcatcctgca gcaggccacg tttgcaatat ttttcactgt ggctatttct
     1981 actgtgttgg ccaaaacaat aactgtggtc acagctttca agctcactac tccagggaga
     2041 aggataagaa agatgatgat aaaagtggca actcacttgc tcattcccat ttgtacccta
     2101 atccaacttg ttctctgtgc aatctggttg gtgacatctc ctccatttat tgacagagat
     2161 atacaatctg aacatgggaa ggtaatcatc atttgcaaca aaggctcagt cattgccttc
     2221 cactttgtct tgggatattt gggctccttg gctctgggga gcttcactgt ggctttcttg
     2281 gctaggaacc ttcctgacag attcaatgag gccaagttcc taacattcag catgttggtg
     2341 ttctacagtg tttggatcac cttcctccct gtctaccaca gcaccagggg gaaggttatg
     2401 gttattgtgg aggttttctc catcttggct tctagtgcag ggttgctagg gtgcatattt
     2461 gtccaaaagt gttatgttct tttagttcga ccagatttaa atgttcttca gaaataa
//
LOCUS       NM_001398581             779 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus phospholipase D family, member 6 (Pld6),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398581 XM_220517
VERSION     NM_001398581.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Nishimasu,H., Ishizu,H., Saito,K., Fukuhara,S., Kamatani,M.K.,
            Bonnefond,L., Matsumoto,N., Nishizawa,T., Nakanaga,K., Aoki,J.,
            Ishitani,R., Siomi,H., Siomi,M.C. and Nureki,O.
  TITLE     Structure and function of Zucchini endoribonuclease in piRNA
            biogenesis
  JOURNAL   Nature 491 (7423), 284-287 (2012)
   PUBMED   23064230
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Ipsaro,J.J., Haase,A.D., Knott,S.R., Joshua-Tor,L. and Hannon,G.J.
  TITLE     The structural biochemistry of Zucchini implicates it as a nuclease
            in piRNA biogenesis
  JOURNAL   Nature 491 (7423), 279-283 (2012)
   PUBMED   23064227
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   6  (bases 1 to 779)
  AUTHORS   Huang,H., Gao,Q., Peng,X., Choi,S.Y., Sarma,K., Ren,H., Morris,A.J.
            and Frohman,M.A.
  TITLE     piRNA-associated germline nuage formation and spermatogenesis
            require MitoPLD profusogenic mitochondrial-surface lipid signaling
  JOURNAL   Dev Cell 20 (3), 376-387 (2011)
   PUBMED   21397848
REFERENCE   7  (bases 1 to 779)
  AUTHORS   Watanabe,T., Chuma,S., Yamamoto,Y., Kuramochi-Miyagawa,S.,
            Totoki,Y., Toyoda,A., Hoki,Y., Fujiyama,A., Shibata,T., Sado,T.,
            Noce,T., Nakano,T., Nakatsuji,N., Lin,H. and Sasaki,H.
  TITLE     MITOPLD is a mitochondrial protein essential for nuage formation
            and piRNA biogenesis in the mouse germline
  JOURNAL   Dev Cell 20 (3), 364-375 (2011)
   PUBMED   21397847
REFERENCE   8  (bases 1 to 779)
  AUTHORS   Choi,S.Y., Huang,P., Jenkins,G.M., Chan,D.C., Schiller,J. and
            Frohman,M.A.
  TITLE     A common lipid links Mfn-mediated mitochondrial fusion and
            SNARE-regulated exocytosis
  JOURNAL   Nat Cell Biol 8 (11), 1255-1262 (2006)
   PUBMED   17028579
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000010.1.
            
            On Dec 20, 2021 this sequence version replaced XM_220517.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.36849.1,
                                           SRR26643293.63057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               JAXUCZ010000010.1  45080202-45080732   c
            532-779             JAXUCZ010000010.1  45078081-45078328   c
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="phospholipase D family, member 6"
                     /db_xref="GeneID:287366"
                     /db_xref="RGD:1311987"
     exon            1..531
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /EC_number="3.1.4.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial cardiolipin hydrolase"
                     /codon_start=1
                     /product="mitochondrial cardiolipin hydrolase isoform 1"
                     /protein_id="NP_001385510.1"
                     /db_xref="GeneID:287366"
                     /db_xref="RGD:1311987"
                     /translation="MGRSSWRLVFAAGAGLALALEALPWLMRWLLAGRRPRREVLFFP
                     SQVTCTEALLQAPGLPPGPSSGCPCSLPHSESSLSRLLRALLAARSSLELCLFAFSSP
                     QLGRAVQLLHQRGVRVRVITDCDYMALNGSQIGLLRKAGIQVRHDQDLGYMHHKFAIV
                     DKKVLITGSLNWTTQAIQNNRENVLIMEDTEYVRLFLEEFERIWEEFDPTKYSFFPQK
                     HRGH"
     misc_feature    387..722
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="Catalytic domain of vertebrate phospholipase D6 and
                     similar proteins; Region: PLDc_vPLD6_like; cd09171"
                     /db_xref="CDD:197268"
     misc_feature    387..722
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="Catalytic domain of vertebrate phospholipase D6 and
                     similar proteins; Region: PLDc_vPLD6_like; cd09171"
                     /db_xref="CDD:197268"
     misc_feature    order(570..572,576..578,615..617,621..623,654..656)
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="putative active site [active]"
                     /db_xref="CDD:197268"
     misc_feature    order(570..572,576..578,615..617,621..623,654..656)
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="putative active site [active]"
                     /db_xref="CDD:197268"
     misc_feature    570..572
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="catalytic site [active]"
                     /db_xref="CDD:197268"
     misc_feature    570..572
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="catalytic site [active]"
                     /db_xref="CDD:197268"
     exon            532..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggggcgg gccccgtaag ggggcgtggc acacccgggg ttgggggcgg gtcggcacgt
       61 gttgggcgcg caagcgcttg gtgctacggc tgacctttga ggtggcggcc atggggcgct
      121 cgagttggcg gttggtgttc gcggccggtg cgggtctcgc gctggcccta gaggcactgc
      181 cgtggttgat gcgttggctg ctggctggga gacggccacg gcgcgaggtg ctcttcttcc
      241 cctcacaggt gacctgcacc gaggctttac tgcaggcccc aggcttgccc cccgggccct
      301 cctcgggctg cccgtgcagt ctcccacaca gcgagagttc gctgagccgc ctgctgcgcg
      361 cgctcttggc tgcccgctcc agcttggagc tctgcctctt cgccttctct agcccgcagc
      421 tgggacgtgc agtgcaacta ctgcaccagc gcggggtgcg cgtgcgggtc atcacggact
      481 gcgactacat ggccctcaac ggctctcaga tcggcctgct gcgcaaggca ggtatacagg
      541 tacggcatga ccaggaccta ggctacatgc accataagtt tgccatcgtt gacaagaagg
      601 tgctcatcac tggctccctc aattggacca cacaggccat ccagaacaac cgtgagaacg
      661 ttctgattat ggaggacacc gagtacgtgc ggctgttcct ggaggagttt gagcgcatct
      721 gggaagaatt tgaccccact aagtacagct ttttccccca aaagcatcga gggcactga
//
LOCUS       NM_001115029            2542 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus leucine, glutamate and lysine rich 1 (Lekr1),
            mRNA.
ACCESSION   NM_001115029 XM_001064656 XM_342255
VERSION     NM_001115029.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158627.1,
            CA339992.1 and JAXUCZ010000002.1.
            
            On Oct 31, 2009 this sequence version replaced NM_001115029.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.12403.1,
                                           SRR26360181.2640322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               BC158627.1         1-788
            789-1398            CA339992.1         60-669
            1399-1575           JAXUCZ010000002.1  152312507-152312683
            1576-1669           JAXUCZ010000002.1  152330583-152330676
            1670-1834           JAXUCZ010000002.1  152345339-152345503
            1835-2134           JAXUCZ010000002.1  152348573-152348872
            2135-2542           JAXUCZ010000002.1  152369134-152369541
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2542
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /note="leucine, glutamate and lysine rich 1"
                     /db_xref="GeneID:361953"
                     /db_xref="RGD:1565425"
     exon            1..424
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    356..358
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /note="upstream in-frame stop codon"
     exon            425..514
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..2542
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /note="leucine-, glutamate- and lysine-rich protein 1"
                     /codon_start=1
                     /product="protein LEKR1"
                     /protein_id="NP_001108501.2"
                     /db_xref="GeneID:361953"
                     /db_xref="RGD:1565425"
                     /translation="MDRHIPMHALPKEIQQMSPEETVCKYCGVSYLILHEFKAMEEKL
                     KAVQEELKFYQGSIEREKRLQEKLQSLSQEFEKYKTDSESKKERVQHASMQLKKQQNE
                     FQRVQKELSHLQLELKIKQKQSQVFSQRLSEYKYFWNKTLLLLTFTKRELTSIKYEIN
                     DNFQNWTSLKGEVFLQIKSISDTALAEIDMLNKSLTVSQRNKVSLEEEMKCLKVLSDA
                     AILRSQQMEASKQHEVNLQARCYELQKEALDLQCQVEALGLRLQKTVKELDNCKEMLM
                     KKSNDANNCERELRKLKFESIISESRHKRLLKEKEDSLITCQQLYKTVQEELTTKGRQ
                     EEDIKRRINLAENELEMTKTLLLQTQEEILTLKNERELMLVSHQKSIEQLQETLRQKL
                     LSDDSWREKIEAELSKERARHRIEFQDQALLFKEEAKLELDIEKEKHQEIIRKYQKEQ
                     EGLQSKIADLIADATKDLRLEVASLQEKLHESHARYTEESESKKKEIEDLKNLVAELE
                     CRLKEETGHDDSVSKELKKEMKQKSDELERVRLAQTQLLQQFSQSQEENTFLQETVRR
                     ECEERFELTEALSQAKEQLLELKRSGGSLRCSLNKGALTHPVSAVSNHRELSNVRHNC
                     GRGTSSASLRGLPKPTATPTPDKLKKVDSSGLPALSQAYPPRGRAISVTEARQRLTAI
                     IRRRLSQQR"
     misc_feature    590..>2269
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    590..>2269
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            515..729
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            730..849
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1025
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1211
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1293
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1371
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1575
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1669
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1834
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2134
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2542
                     /gene="Lekr1"
                     /gene_synonym="RGD1562738; RGD1565425"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttttacac ccagcggagt cccgggctag gtgagggtca tggcctttct cagttctcag
       61 aggaccaggc cggcagggac tttgttccgg ggctaaggcc agccgcgcgg gacggcgggg
      121 cagcgggggc ggggaggagg aaggcagggc ggcctctcgg tgcctcgggc gaggcctggg
      181 ccggcgcggt cgagtcgggc agttagtttc ctgcagtcgc ggggcgtgac ctcccgctct
      241 cctgcccctg acctgccctc ttgtgaatca cggcccggga atggtactag aggaagggcc
      301 tggaagcaga accggagtta atgaccgggc gtgacaccgg tgtaagagtc ggaaatgaac
      361 caccaaggac gtttcggcat ttaagaacac acacgtctat ctcgtgacca gtgtcacaga
      421 gaagcctgtt tttctgcagt gctctctcag tgcgattaga ggagtcatgg atcgtcacat
      481 tcccatgcac gccttaccca aagaaatcca acagatgtct cctgaagaaa cagtttgtaa
      541 atactgtggc gtcagctacc taattctaca tgaatttaag gctatggaag aaaaactgaa
      601 agcggtgcaa gaagaattga aattttatca aggaagtata gaacgagaaa agagacttca
      661 agaaaagctg cagtctctta gccaggagtt tgaaaagtat aaaactgaca gcgaatccaa
      721 gaaggaaaga gttcaacatg caagcatgca gttaaaaaag caacaaaatg aatttcagag
      781 agtacagaaa gaattaagtc atctacaact tgagttaaaa attaaacaaa aacaatctca
      841 agtcttcagt caaagattgt cagaatacaa atacttctgg aataagactc ttttattact
      901 tacttttact aaaagggaac taacaagtat taaatatgaa ataaatgata attttcaaaa
      961 ctggacttca ctgaaaggag aagtgtttct acaaattaaa tctataagtg atacagcctt
     1021 ggcagagata gatatgttaa ataagagtct gacagtgtct cagagaaata aggtaagcct
     1081 ggaagaggaa atgaaatgtc tcaaagtgtt gtcggatgca gccatattga ggtctcagca
     1141 gatggaggcg tccaagcagc atgaagtgaa cctgcaagcc aggtgctacg agctgcagaa
     1201 ggaggcactg gatttacagt gtcaagtaga ggcccttggg ctgagacttc agaagacagt
     1261 gaaggagctg gacaactgta aagagatgct catgaaaaaa tctaatgatg ctaataactg
     1321 tgaaagagaa cttagaaaac tgaagtttga gtccattatc tctgagtcaa ggcacaaaag
     1381 gctacttaaa gaaaaagaag actctttaat tacttgtcaa caactatata aaaccgtaca
     1441 ggaagagctg actacaaaag ggagacaaga ggaagatata aagcgaagaa tcaaccttgc
     1501 cgaaaatgaa ctagagatga ccaaaacgct cctgcttcag acacaggaag aaattttaac
     1561 gctgaaaaat gaaagggaat tgatgctggt ttctcatcag aaaagcatcg agcagctgca
     1621 ggaaaccctg agacagaagc tgctgagcga tgacagctgg agggagaaga ttgaagctga
     1681 gctcagcaag gaaagagccc ggcatcgcat tgagttccag gaccaagctc ttctctttaa
     1741 ggaggaagct aaactggaac ttgacattga aaaagaaaag caccaggaaa taatccggaa
     1801 gtatcagaaa gaacaagagg gcctgcagag caagatagct gacctaatcg cagatgctac
     1861 aaaagacctg aggctggaag tggcctctct ccaagaaaaa ctccatgagt cccatgcgcg
     1921 gtacacagaa gagtctgagt caaagaaaaa agaaattgaa gacctgaaaa atctggttgc
     1981 agaattggag tgtcgtttga aggaggaaac tggccatgat gattcagttt ccaaagagtt
     2041 gaagaaggaa atgaaacaga agtcagatga gctggaaaga gtaaggctgg cccagacaca
     2101 gctgctgcag cagttcagcc agtcacagga agagaacact tttctccagg aaacagtgcg
     2161 cagagagtgt gaagaacgct ttgaactgac agaggctttg agtcaagcca aagaacagct
     2221 cctggagctt aagaggagcg gaggaagctt acggtgttcc ctcaataagg gtgccctaac
     2281 ccaccctgtc tcggcagtca gtaatcaccg cgagctaagc aatgtgagac acaactgtgg
     2341 acgaggcacc agctcggcca gcctgcgcgg actgccaaaa cccaccgcaa ccccaacccc
     2401 agataaactc aagaaggtcg acagctccgg actgcctgcc ctttcccagg catatcctcc
     2461 caggggccga gcaatttcag taaccgaggc caggcagagg ttgacagcca tcattcgcag
     2521 gaggctgagt cagcagcgat ga
//
LOCUS       NM_001099489            2562 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 13 (Vom2r13), mRNA.
ACCESSION   NM_001099489 XM_001074899
VERSION     NM_001099489.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 1, 2024 this sequence version replaced NM_001099489.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  70802849-70803045
            198-489             JAXUCZ010000001.1  70804905-70805196
            490-1290            JAXUCZ010000001.1  70805510-70806310
            1291-1518           JAXUCZ010000001.1  70834467-70834694
            1519-1642           JAXUCZ010000001.1  70850097-70850220
            1643-2562           JAXUCZ010000001.1  70852325-70853244
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2562
                     /gene="Vom2r13"
                     /note="vomeronasal 2 receptor, 13"
                     /db_xref="GeneID:690593"
                     /db_xref="RGD:1594671"
     CDS             1..2562
                     /gene="Vom2r13"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 13"
                     /protein_id="NP_001092959.3"
                     /db_xref="GeneID:690593"
                     /db_xref="RGD:1594671"
                     /translation="MFTLILSFLFLNIPFQVTGFIYPTCSWRIKENKDKSGNERIGCF
                     FLIQAVQKPVEKEYFSHFFNTQKHTEIHKYSLVLAFSMIEVNRNPDLLPNMSLVFSFR
                     EIICGWQPELSIFIEVNLDDYGVLPNYTCKDESLCGVALTGVNWAPTLLLYTILNNFK
                     SQQFPHLTYGHFHPVLSDHENFPYLYQMASDDTSLALALVSFIIHFRWNWIGLAISDN
                     DQGTQFLSYLKRGMEKNAICLAFVSMIPVNMHLYMSRAEVYYSQIMTSSANVVIIYGD
                     TGSTLAVSFRMWESLGLQRLWITTTQLDVTPSMKDNVYGLFAFGHHHGVISGFKNFVQ
                     TLNPVTYSNENLAKLEWMHFNCEVSASKWKTLKNFSSNHSLEWLMEHTFEMTFSEGSY
                     NIYNAVYTVAHVLHEMTFQKFHNLPNAKGKVENYVCNKLGAPLRKIHFTNPVGDRVSM
                     NQEDKLQEEYDIFYIWNFPQGLEFKVKIGLFSPYFINGQQLHLSGDMKEWARGSTQMP
                     TSVCSADCGPGFRKFRKKEMSACCFDCSPCPENEISNETNLEMCVLCPEDKYANTGQN
                     DCIPKALIFLSYEDHLGMALSLMALGFSAFTAVILGIFVKHHSTPIVKANNSTLTYIL
                     LLSLIFCFLCPLLFIGHPDSVTCILQQITFGVLFTMAISTVLAKTITVILAFKVTAPQ
                     RMMKYFLLSGVSTYIIPICTLIQVIVCAVCLGVSPPSVEIDAQSEHGHIIIVCNKGSV
                     TCFYSILGYLACLTFVSFTLAFLSRNLPGVFNEAKLITFSMLVVCSVWVTFLPVYHST
                     KGKIMVAGEIISILASSSGMLVCIFIPKCYIILFRPEKNSLKMIREKSPSHTHIS"
     misc_feature    121..1500
                     /gene="Vom2r13"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1500
                     /gene="Vom2r13"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1168..1170)
                     /gene="Vom2r13"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1168..1170)
                     /gene="Vom2r13"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,460..462,730..732)
                     /gene="Vom2r13"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,460..462,730..732)
                     /gene="Vom2r13"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1522..1683
                     /gene="Vom2r13"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1522..1683
                     /gene="Vom2r13"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1744..2496
                     /gene="Vom2r13"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..2496
                     /gene="Vom2r13"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..1818
                     /gene="Vom2r13"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1744..1818
                     /gene="Vom2r13"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r13"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r13"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r13"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r13"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r13"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r13"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r13"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r13"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r13"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r13"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r13"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r13"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r13"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r13"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r13"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r13"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
     exon            198..489
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1290
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1518
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1642
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2562
                     /gene="Vom2r13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcactc tgattttgtc tttcttgttc ctcaacattc catttcaggt gactggtttt
       61 atttatccca cctgctcttg gagaataaaa gagaataaag acaagagtgg aaatgagaga
      121 attggctgtt tcttcttgat tcaagcagta caaaagcctg tggagaaaga gtatttcagt
      181 cattttttca atacacaaaa acacactgaa atccacaagt attctcttgt cttggctttt
      241 tccatgattg aagtcaacag gaaccctgat cttttgccaa atatgtctct agtattttca
      301 tttcgagaaa taatttgtgg ttggcaaccc gaattatcaa ttttcattga agtgaattta
      361 gatgattatg gagttctccc taattatacc tgtaaagatg aaagtctgtg tggagtggca
      421 cttacaggag taaactgggc accaactctg ttactttata caatcctaaa caacttcaaa
      481 tctcagcagt tccctcatct tacttacgga cactttcatc ctgttctgag tgatcatgaa
      541 aattttccct atctatatca gatggcctct gatgatacat ctctagccct tgccctggtc
      601 tccttcataa ttcattttcg ttggaactgg atagggttgg ccatctcaga caatgatcaa
      661 gggacccagt ttctctctta tttgaaaaga gggatggaaa aaaatgcaat ctgtcttgct
      721 tttgtgagca tgatcccagt caatatgcat ttatacatgt caagagctga agtgtattac
      781 agtcaaatca tgacatcatc cgcaaatgtt gttatcattt atggcgacac aggcagtact
      841 ttagctgtga gttttagaat gtgggaatct ctaggtttac agagattatg gatcaccacc
      901 acacagttgg atgtcactcc tagcatgaaa gacaatgtat atggtttatt tgcttttgga
      961 caccaccatg gtgtgatttc tggttttaaa aattttgtcc agacattgaa tcctgtcaca
     1021 tactcaaatg aaaatctggc aaagctggaa tggatgcact ttaactgtga agtctcagca
     1081 tctaaatgga agacactgaa gaacttttca tctaatcact cactggaatg gctaatggaa
     1141 catacttttg aaatgacctt tagtgaagga agttataaca tatacaatgc tgtgtatact
     1201 gttgcgcatg tacttcatga gatgactttt caaaagtttc ataatctgcc caatgccaaa
     1261 gggaaagtag aaaattatgt ctgcaataag ctgggtgccc ctctgagaaa gatccacttc
     1321 actaatccag ttggggacag agtaagtatg aatcaagaag acaaactgca ggaagaatat
     1381 gacattttct acatttggaa ttttccacag ggacttgaat ttaaagtgaa aataggacta
     1441 tttagtccct attttataaa tggtcaacag ttacatttat ctggagatat gaaagagtgg
     1501 gcaagaggaa gtacacagat gccgacctct gtgtgcagtg ctgattgtgg tccaggattt
     1561 agaaaattca gaaagaagga aatgtcagcc tgttgttttg attgcagtcc ctgcccagaa
     1621 aatgaaattt ctaatgagac aaacttggag atgtgtgtcc tgtgcccaga ggacaaatat
     1681 gccaacacag gacagaatga ctgcattcca aaagctctta tctttctcag ttatgaagac
     1741 cacctgggga tggcactttc tttaatggcc ttgggcttct ctgcattcac agctgtgatt
     1801 cttggcatct ttgtgaagca ccacagtact cccattgtta aggccaataa cagcactctc
     1861 acctacatct tgctcctctc cctcattttt tgtttccttt gccccttgct cttcattggc
     1921 catccagact cggtcacatg catcctacag caaatcacat ttggagttct attcaccatg
     1981 gctatttcca cagtgttagc caaaacaatt actgttattc tggcattcaa agtcacagca
     2041 cctcaaagaa tgatgaagta ctttcttctt tcaggagtat ctacgtacat cattcccatc
     2101 tgcactctca tccaagttat tgtctgtgca gtctgtttag gagtttctcc tccttctgtt
     2161 gaaattgatg ctcaatctga gcatggtcac attatcattg tttgcaacaa gggttcagtc
     2221 acttgttttt acagtattct gggatacctg gcctgcctga cctttgtgag cttcactctg
     2281 gctttccttt ccagaaacct gcctggtgtc ttcaatgaag ccaagttaat aacattcagc
     2341 atgctggtgg tctgcagtgt ctgggttact ttcctccccg tttaccatag cacaaaaggc
     2401 aagatcatgg tggctggtga gatcatttcc attttggctt ccagttcagg gatgctggta
     2461 tgcattttca ttcccaaatg ttacataata ctctttagac cagaaaaaaa ttctcttaaa
     2521 atgatcaggg agaaatcacc ttcccatact cacatttctt aa
//
LOCUS       NM_001166763             897 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 55 (Vom1r55), mRNA.
ACCESSION   NM_001166763
VERSION     NM_001166763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 897)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-897               JAXUCZ010000001.1  82795673-82796569
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..897
                     /gene="Vom1r55"
                     /note="vomeronasal 1 receptor 55"
                     /db_xref="GeneID:691791"
                     /db_xref="RGD:1595934"
     CDS             1..897
                     /gene="Vom1r55"
                     /note="vomeronasal 1 receptor Vom1r55; vomeronasal 1
                     receptor 1-like"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 55"
                     /protein_id="NP_001160235.1"
                     /db_xref="GeneID:691791"
                     /db_xref="RGD:1595934"
                     /translation="MVQITVDDMVLKVVILLQMGTGLLANTYLLFMHSFVLLTGHRPK
                     PTELILSNLALANSLVLLSKGAQQVMEDLGLVHVLEGFGCQVFFYFHRVSRELLLCST
                     SLLSCFQAVTVSPRHGVWTGLRRWVYRHVGCSCFFCWSFNLVISTISPIEIKVFGDII
                     SNSSMGDGIACQYVVAVSGLCAIPLAILGALLMTLMVAASTHMVCLLHRHHQRVQHVR
                     SCNLTYRTSPEMRATHSILLLVAGFILFYFLNSIYIFYSIKSFSSYLWLQHSLKFFAT
                     CFPSLSPLVLIFQNSRTPSPCF"
     misc_feature    34..894
                     /gene="Vom1r55"
                     /note="Vomeronasal organ pheromone receptor family, V1R;
                     Region: V1R; pfam03402"
                     /db_xref="CDD:460912"
     misc_feature    34..894
                     /gene="Vom1r55"
                     /note="Vomeronasal organ pheromone receptor family, V1R;
                     Region: V1R; pfam03402"
                     /db_xref="CDD:460912"
     exon            1..897
                     /gene="Vom1r55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgcaaa taactgttga tgatatggtc ttgaaggttg ttatcctgtt gcagatgggc
       61 acaggccttc tggcaaacac ttatttgctc ttcatgcata gcttcgtcct tctcacaggg
      121 cacaggccga agcctacaga gctcattttg tccaacttgg ctctggccaa ttccttggtt
      181 cttctctcca agggggcaca gcaggtgatg gaagatttgg gactggtgca tgttctggaa
      241 ggatttgggt gtcaagtctt cttttacttc cacagggtgt ctcgagaact tttgctctgc
      301 agcaccagct tgctgagctg ttttcaggca gtcacagtca gccccaggca tggagtgtgg
      361 acagggctca gacgctgggt ttataggcat gttggctgct cctgcttctt ctgctggagt
      421 ttcaatctgg tcatcagcac catctctccc atcgagataa aagtctttgg ggatatcatt
      481 agtaattcct caatggggga tggcattgct tgccagtatg tggtcgctgt gtctggattg
      541 tgtgcaatcc cgttagccat tctgggtgcc ctgctgatga cacttatggt ggcagccagc
      601 actcacatgg tatgtctcct gcacagacac caccagaggg tccaacatgt tcgaagttgc
      661 aacctcactt acaggacctc cccagagatg agggccactc acagcatcct actcttggtg
      721 gctggcttca tcctctttta cttcctgaat tcaatctaca tattttacag cataaaatca
      781 tttagctcct acctgtggct gcaacattcc ctgaagtttt ttgccacctg tttcccctcc
      841 ctgagtccct tggtactgat tttccagaat tccagaactc caagcccctg cttttag
//
LOCUS       NM_001409399             978 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus olfactory receptor family 13 subfamily C member
            3B (Or13c3b), mRNA.
ACCESSION   NM_001409399 XM_006238173
VERSION     NM_001409399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000005.1.
            
            On Jul 15, 2022 this sequence version replaced XM_006238173.4.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-978               JAXUCZ010000005.1  72167882-72168859   c
FEATURES             Location/Qualifiers
     source          1..978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q23"
     gene            1..978
                     /gene="Or13c3b"
                     /note="olfactory receptor family 13 subfamily C member 3B"
                     /db_xref="GeneID:100912327"
                     /db_xref="RGD:6487777"
     exon            1..978
                     /gene="Or13c3b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4..6
                     /gene="Or13c3b"
                     /note="upstream in-frame stop codon"
     CDS             16..978
                     /gene="Or13c3b"
                     /note="olfactory receptor 13C3; olfactory receptor
                     13C3-like"
                     /codon_start=1
                     /product="olfactory receptor family 13 subfamily C member
                     3B"
                     /protein_id="NP_001396328.1"
                     /db_xref="GeneID:100912327"
                     /db_xref="RGD:6487777"
                     /translation="MDDMDKNNQTFVSEFLLLGLSGYPKTEILYFVIVLVMYLVILTG
                     NGVLIIASIFDSHLHTPMYFFLGNLSFLDICYTTSSVPSTLVSLISKKRNISFSGCTV
                     QMFVGFAMGSTECLLLGMMAFDRYVAICNPLRYSVIMSKEVYVSMASASWFSGGINSV
                     VQTSLAMRLPFCGNNVINHFTCEVLAVLKLACADISLNIVTMVISNMAFLVLPLLLIF
                     FSYVFILYTILRMNSASGRRKAFSTCSAHLTVVVIFYGTIFSMYAKPKSQDLTGKDKF
                     QTSDKIISLFYGVVTPMLNPIIYSLRNKDVKAAVKYILKQKYIP"
     misc_feature    97..924
                     /gene="Or13c3b"
                     /note="olfactory receptor family 13 and related proteins,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_OR13-like;
                     cd15430"
                     /db_xref="CDD:320547"
     misc_feature    97..924
                     /gene="Or13c3b"
                     /note="olfactory receptor family 13 and related proteins,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_OR13-like;
                     cd15430"
                     /db_xref="CDD:320547"
     misc_feature    100..180
                     /gene="Or13c3b"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320547"
     misc_feature    100..180
                     /gene="Or13c3b"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320547"
     misc_feature    199..279
                     /gene="Or13c3b"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320547"
     misc_feature    199..279
                     /gene="Or13c3b"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320547"
     misc_feature    order(265..267,274..279,313..330,334..339,346..348,
                     481..483,487..501,607..609,616..624,628..636,640..645,
                     778..780,787..792,796..801,808..810,844..849,853..861,
                     868..870,877..882)
                     /gene="Or13c3b"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320547"
     misc_feature    order(265..267,274..279,313..330,334..339,346..348,
                     481..483,487..501,607..609,616..624,628..636,640..645,
                     778..780,787..792,796..801,808..810,844..849,853..861,
                     868..870,877..882)
                     /gene="Or13c3b"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320547"
     misc_feature    313..405
                     /gene="Or13c3b"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320547"
     misc_feature    313..405
                     /gene="Or13c3b"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320547"
     misc_feature    442..507
                     /gene="Or13c3b"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320547"
     misc_feature    442..507
                     /gene="Or13c3b"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320547"
     misc_feature    607..699
                     /gene="Or13c3b"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320547"
     misc_feature    607..699
                     /gene="Or13c3b"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320547"
     misc_feature    718..810
                     /gene="Or13c3b"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320547"
     misc_feature    718..810
                     /gene="Or13c3b"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320547"
     misc_feature    847..924
                     /gene="Or13c3b"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320547"
     misc_feature    847..924
                     /gene="Or13c3b"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320547"
ORIGIN      
        1 caatgatggc tgaccatgga tgacatggat aaaaataacc agacatttgt ttctgaattc
       61 cttcttttgg gtctttctgg atacccaaag accgagatcc tttattttgt tattgttctt
      121 gttatgtatc tagtgattct aactggcaat ggtgttctga tcatagcaag catctttgat
      181 tcccatcttc acacgcccat gtacttcttc ctgggcaacc tctccttcct ggatatctgc
      241 tacacaacat cttctgttcc ttcaacattg gtgagcctga tttcaaagaa aagaaacatt
      301 tctttctctg gttgtacagt gcagatgttc gttggatttg caatgggctc aacagaatgt
      361 ttgcttcttg gcatgatggc ttttgatcgc tacgtggcca tctgcaaccc tctgagatac
      421 tccgtcatca tgagcaaaga ggtgtatgta tccatggcat ctgcatcatg gttctctggt
      481 ggaatcaatt cagttgtgca aacatccctt gccatgcggc tgcctttctg tgggaataat
      541 gttattaacc attttacttg tgaggtctta gctgtcctca agctagcatg tgctgatata
      601 tctctcaata ttgttaccat ggtgatatca aatatggctt tcctggttct tccactacta
      661 ctcatctttt tctcctacgt gttcatcctc tacacaatct tgagaatgaa ctcagcttca
      721 gggagacgca aagcattttc cacctgctct gcccacctga ctgtggtggt catattttat
      781 ggaactatct tttctatgta cgcaaaacct aagtctcaag atctgactgg gaaagacaag
      841 ttccaaactt cagataagat catttcttta ttttatggag tagttacccc catgctaaat
      901 ccaatcattt acagcttgag gaataaggat gttaaagctg ctgtaaaata catactgaaa
      961 cagaagtaca tcccataa
//
LOCUS       NM_001167549             948 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 16 (Vom1r16), mRNA.
ACCESSION   NM_001167549
VERSION     NM_001167549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               JAXUCZ010000001.1  69334768-69335715   c
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..948
                     /gene="Vom1r16"
                     /note="vomeronasal 1 receptor 16"
                     /db_xref="GeneID:100312668"
                     /db_xref="RGD:2316472"
     CDS             1..948
                     /gene="Vom1r16"
                     /note="vomeronasal 1 receptor Vom1r16"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 16"
                     /protein_id="NP_001161021.1"
                     /db_xref="GeneID:100312668"
                     /db_xref="RGD:2316472"
                     /translation="MDASELSIGVIILSQTVIGVLANFFLLYHCMILYLTRYRLRSID
                     CVLMQLSVANILTILSKGITQTIAAFGLKDFLNDIGCKLTFFVHKVGKSVCIGSTSFL
                     SVFQAIIISPRDSRCSKLKVKVHKYICYSVYLNWVIFFIISIINLLHLRAKYNNESTI
                     TLKSYVYCYSVRHDPTSDILHAVLVSGPDIIFLGLMMYSNGFMVLTLYRHKQKMQQMP
                     RMNVSSISSPASRATKTILLLVSTFVSFYTISSLCHLLVVILYNPSWILVNVAAMSAS
                     FFPTVYPFLLMSHDSWALSFCLLLKRNRYFPKDSSQELN"
     misc_feature    22..870
                     /gene="Vom1r16"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..870
                     /gene="Vom1r16"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..96
                     /gene="Vom1r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    22..96
                     /gene="Vom1r16"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    130..195
                     /gene="Vom1r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    130..195
                     /gene="Vom1r16"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Vom1r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Vom1r16"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    388..438
                     /gene="Vom1r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    388..438
                     /gene="Vom1r16"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    541..612
                     /gene="Vom1r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    541..612
                     /gene="Vom1r16"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    697..765
                     /gene="Vom1r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    697..765
                     /gene="Vom1r16"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    793..870
                     /gene="Vom1r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    793..870
                     /gene="Vom1r16"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..948
                     /gene="Vom1r16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatgcca gtgaactgtc tataggagtg atcatcttgt ctcagactgt gattggagtt
       61 ttggctaatt tctttctcct gtaccactgt atgattcttt acttaacaag gtacaggttg
      121 aggtctatag actgtgttct gatgcagtta agtgtagcca acatcttaac aattttgtcc
      181 aaaggcataa cccagacaat tgcagctttt ggcttgaaag acttcctcaa tgatattgga
      241 tgcaaactga ctttctttgt tcacaaagta ggtaaaagtg tttgtattgg tagcacttcc
      301 tttctcagtg tattccaggc catcatcatc agtcccaggg attccagatg ttcaaagctt
      361 aaagtaaaag tgcacaagta tatttgttat tctgtgtacc tgaactgggt gatatttttc
      421 attataagca ttattaatct tttgcatctg agggcaaaat ataacaatga aagtacaata
      481 actctgaaat cttatgtata ctgctattct gttcgtcatg acccaaccag tgacatccta
      541 catgcagtat tggtgtcagg tcctgacata attttcctag gtctcatgat gtacagcaat
      601 ggcttcatgg ttctaaccct gtataggcat aagcaaaaga tgcagcaaat gcccaggatg
      661 aatgtttctt ccatatcctc ccctgcatcc agagccacca aaacaatcct tctcctagtc
      721 agtacttttg tctcctttta cacaatctct tctctatgtc atctcttagt agttatcttg
      781 tataatccca gctggattct agtgaatgtg gctgcaatgt ctgcttcgtt tttccccact
      841 gtttatccct ttctcctcat gagccatgat tcttgggcac tcagcttctg cctgctcttg
      901 aaaaggaata gatattttcc caaagactct agccaagaac tgaactga
//
LOCUS       NM_001099515            2565 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 49 (Vom2r49), mRNA.
ACCESSION   NM_001099515 XM_001066737
VERSION     NM_001099515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 26, 2007 this sequence version replaced XM_001066737.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN09345330 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000004.1  158419670-158419884
            216-513             JAXUCZ010000004.1  158421000-158421297
            514-1323            JAXUCZ010000004.1  158428020-158428829
            1324-1548           JAXUCZ010000004.1  158437857-158438081
            1549-1672           JAXUCZ010000004.1  158454545-158454668
            1673-2565           JAXUCZ010000004.1  158465885-158466777
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2565
                     /gene="Vom2r49"
                     /note="vomeronasal 2 receptor, 49"
                     /db_xref="GeneID:688392"
                     /db_xref="RGD:1589986"
     CDS             1..2565
                     /gene="Vom2r49"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 49 precursor"
                     /protein_id="NP_001092985.1"
                     /db_xref="GeneID:688392"
                     /db_xref="RGD:1589986"
                     /translation="MKLLIAFSLLILLTAFQEQISCFSLSKPASPGYYQDGDFVIGGL
                     FSLRVTAGDTRSKFGFTDTTHIPEHVYVDFTKHYQHMLAMVFAIENINKDPNILFNMS
                     LGFYLFNVDFIEMKAVESSMALLSGESPAVPNYSCRPEKTDKLVAVIGGISTGISTQI
                     SQLLSLYNVPQISYAPFDQSFETKVQLQSPYQFPVHTTALYQGIIQLLLYFSWVWVGL
                     VVPDDVRGELFLRDITEEMNNHGLCVAFAEKFPEFPAKDTGNREHFMERFTLTRVIVA
                     FGDTYSLLRFVYIIFCNTPFGNVWVTTSDWDITTLPFQQNLGYTYFGGGLSFSVHMDE
                     ILGFKNFLRSVQPRKYPQDIFIQDVWSILFECPYFDQHWIRELSQCEQNGNLSTRPLH
                     FWDMNTSPSSYKVHEAVYAIAQALHEELLLTLEGDSLHKDLPQAPLPWKLHPFLQKGQ
                     LRRSSNEENVVNKEVSATKLDIFNYQSLQNGSKAQVKVGEFVFESHSVQHFSLNEELI
                     TFGEHHSQTPFSVCSPSCPLGFRKSPVEGKPFCCFDCLPCPDGEIANETDMDQCIKCP
                     EDQYPNRQRNQCLPKITEFLSHEDTLGAVFVSIAISLSALSAMILGLFICYRDTSIVR
                     ANNRNLSYLLLVSLMLCFFCSLIFIGQPRTVTCVLRQMIFGIVFSVAVSTILAKTFIV
                     VVAFKAIKPGSALKMSMVIRLSNTIVFCGSIIQVCICAVWLGTYPPFPDVDMHSEFGQ
                     IILWCNEGSTLAFYCVLGYLGFLASLSLLIAFLARRLPDSFNETKTITFSMLVFCSVW
                     ISFVPTYLSSKGKTMVAVEILSILASSAGLLGCIFLPKCYMILMSSGGHSRIKFFK"
     sig_peptide     1..66
                     /gene="Vom2r49"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    118..1527
                     /gene="Vom2r49"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    118..1527
                     /gene="Vom2r49"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1552..1713
                     /gene="Vom2r49"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1552..1713
                     /gene="Vom2r49"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1771..2526
                     /gene="Vom2r49"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1771..2526
                     /gene="Vom2r49"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1771..1848
                     /gene="Vom2r49"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1771..1848
                     /gene="Vom2r49"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1780..1782,1789..1794,1801..1806,1810..1815,
                     1915..1917,1927..1929,1936..1941,1963..1965,1975..1977)
                     /gene="Vom2r49"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1780..1782,1789..1794,1801..1806,1810..1815,
                     1915..1917,1927..1929,1936..1941,1963..1965,1975..1977)
                     /gene="Vom2r49"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1882..1947
                     /gene="Vom2r49"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1882..1947
                     /gene="Vom2r49"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1942..1944,1978..1983,1990..1995,2002..2004,
                     2242..2244,2257..2259,2266..2271,2278..2280,2380..2382,
                     2389..2394,2401..2403,2413..2415,2437..2442,2449..2451,
                     2458..2460,2470..2472)
                     /gene="Vom2r49"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1942..1944,1978..1983,1990..1995,2002..2004,
                     2242..2244,2257..2259,2266..2271,2278..2280,2380..2382,
                     2389..2394,2401..2403,2413..2415,2437..2442,2449..2451,
                     2458..2460,2470..2472)
                     /gene="Vom2r49"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1972..2046
                     /gene="Vom2r49"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1972..2046
                     /gene="Vom2r49"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2116..2166
                     /gene="Vom2r49"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2116..2166
                     /gene="Vom2r49"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2245..2325
                     /gene="Vom2r49"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2245..2325
                     /gene="Vom2r49"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2347..2418
                     /gene="Vom2r49"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2347..2418
                     /gene="Vom2r49"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2431..2508
                     /gene="Vom2r49"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2431..2508
                     /gene="Vom2r49"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..215
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
     exon            216..513
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1323
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1548
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1672
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..2565
                     /gene="Vom2r49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaattac tcattgcttt ctctctcctg attttgctca ctgcattcca ggaacaaatt
       61 tcttgtttct ctttaagtaa acctgcttct cctggctact atcaagacgg ggattttgtt
      121 attggaggac tcttttccct tagagtgact gctggagaca ctagaagcaa atttggcttt
      181 acagacacaa cccatatacc agaacatgtt tatgtggatt tcaccaaaca ttatcagcac
      241 atgttggcaa tggtttttgc tatagaaaat atcaacaagg atccaaatat tttattcaat
      301 atgtccctgg gattctatct cttcaatgtt gactttattg agatgaaggc tgtggagagt
      361 tctatggctt tgctctctgg agagagcccc gcagttccta actacagctg caggcctgag
      421 aagactgata agctggttgc agtgatagga ggcatttcaa caggaatatc aacccagatc
      481 tcccaacttc taagtctcta caatgtccca cagatcagct atgctccttt tgaccagagt
      541 tttgagacca aagtccagct ccagtctcct taccagtttc ctgtgcacac cacagctctg
      601 tatcagggaa ttattcaact gctgctatac ttctcttggg tctgggttgg cctggtggtt
      661 ccagatgatg tgaggggaga actcttcctt agggacatca cagaggagat gaacaaccat
      721 ggactttgtg ttgcatttgc agaaaagttt ccagaatttc ctgctaagga cacaggaaac
      781 agggaacatt ttatggaaag attcacattg acccgtgtta ttgttgcatt tggtgacaca
      841 tattctcttc tgagatttgt ctatattatc ttttgtaata cccctttcgg taatgtctgg
      901 gtcacaactt ctgattggga tatcaccaca ttaccctttc aacaaaatct aggttataca
      961 tattttggtg gaggattatc attttctgtt cacatggatg aaattctggg attcaagaat
     1021 tttcttagaa gtgttcaacc taggaaatac cctcaagata tctttatcca ggatgtgtgg
     1081 tcaatcttat ttgaatgtcc ctattttgat cagcactgga tcagggaact gagtcaatgt
     1141 gagcaaaatg gcaacctcag tacacgacct ctgcattttt gggatatgaa tacctcaccc
     1201 tcgagctaca aagttcatga agctgtgtat gctattgccc aggcactcca tgaggagctc
     1261 ttactcacat tggaaggaga ctcactccat aaagatttac cccaggctcc tctcccatgg
     1321 aagcttcatc cattcttaca aaagggccaa cttaggagaa gctccaatga ggagaatgta
     1381 gtaaacaagg aggtttcagc aaccaagctt gacatcttta attaccagtc tctgcagaac
     1441 ggtagcaaag ctcaagtgaa agttggcgag tttgtctttg agtctcacag tgttcagcat
     1501 ttttccctaa atgaggaact cataactttt ggtgaacacc acagtcagac acctttttct
     1561 gtttgcagtc caagttgtcc tcttggattt aggaaatcac ctgttgaagg gaaaccattc
     1621 tgttgttttg attgtctccc atgtccagat ggagagattg caaatgaaac agatatggat
     1681 caatgcatca agtgtcctga agatcaatat ccaaatagac agaggaatca gtgtcttcct
     1741 aaaatcacag aatttttgtc ccatgaagat actttgggag ctgtttttgt ctccatagcc
     1801 attagtttat ctgccttgtc agctatgatt ttaggattat ttatctgcta tcgagacaca
     1861 tccattgtca gagcaaataa cagaaatctc agttatctcc tcctggtttc tctaatgctc
     1921 tgtttctttt gctcattaat attcattggc cagcccagaa cagtcacttg tgtcttgaga
     1981 caaatgattt ttgggattgt attttctgtt gctgtttcta ctatcttggc aaagaccttc
     2041 attgtggttg tggccttcaa agccatcaaa ccaggaagtg ccttaaaaat gtcgatggtg
     2101 atccgactct caaacactat agtcttctgt ggttccatca ttcaagtgtg catctgtgca
     2161 gtctggctgg gaacgtatcc ccctttccct gatgtcgaca tgcactcaga gtttgggcaa
     2221 atcatcctct ggtgtaatga gggctccacc cttgccttct attgtgttct ggggtacttg
     2281 ggctttctag ccagtctcag tttgcttatt gcttttctag cgagaaggct acctgacagc
     2341 tttaatgaga caaaaacaat aacattcagc atgctggttt tctgtagtgt gtggatttct
     2401 tttgtaccca cttacttgag ctccaaaggc aaaaccatgg tggctgtgga aattctttca
     2461 attctggctt ccagtgctgg cttactgggc tgtatatttc ttcccaaatg ctatatgatc
     2521 ttaatgagtt caggtggcca ttcacgaata aagttcttta aatga
//
LOCUS       NM_001410263            1234 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, locus T24, gene 1 (RT1-T24-1),
            transcript variant 1, mRNA.
ACCESSION   NM_001410263
VERSION     NM_001410263.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   2  (bases 1 to 1234)
  AUTHORS   Brorson,K.A., Hunt,S.W. 3rd, Hunkapiller,T., Sun,Y.H.,
            Cheroutre,H., Nickerson,D.A. and Hood,L.
  TITLE     Comparison of exon 5 sequences from 35 class I genes of the BALB/c
            mouse
  JOURNAL   J Exp Med 170 (6), 1837-1858 (1989)
   PUBMED   2584927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CM038666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.76902.1,
                                           SRR8487230.143865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                CM038666.1         2823209-2823306
            99-395              CM038666.1         2827486-2827782
            396-668             CM038666.1         2829114-2829386
            669-944             CM038666.1         2829697-2829972
            945-1082            CM038666.1         2830100-2830237
            1083-1234           CM038666.1         2830413-2830564
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHRSP/BbbUtx"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1234
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="RT1 class I, locus T24, gene 1"
                     /db_xref="GeneID:361787"
                     /db_xref="RGD:1359499"
     exon            1..98
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1234
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histocompatibility 2, T region locus 24"
                     /codon_start=1
                     /product="RT1 class I, locus T24, gene 1 isoform 1"
                     /protein_id="NP_001397192.1"
                     /db_xref="GeneID:361787"
                     /db_xref="RGD:1359499"
                     /translation="MWSLIFCFLSHPQDTGARSHSLHYSYSAVTEPGPGVPAFFASGF
                     VDNQPFIHYDSRKMEAEPCADWLRENPYYFDEETQVFTNRMKIFQLSLRNIQQYYNSS
                     GDRSQRADGFHQQAGPHTLQFTYGCEMQGNRTTGHWQYGYDGRDYLTLDLDSMEYTAA
                     TFIAGYTKHKWQNNEYWLEREKTYLEKECVLWLKRYLTMGGENFTRTDPPQTTVTHHP
                     RPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPTGDGTFQKWAAVVVPL
                     GKEQKYTCHVEHEGLPEPLTQRWEAPPGTDSNMGINVIAVVLQAVAIIAAVAIIIVTV
                     VRRRRRRRRNTGGEGDYTPAPRSLSIFIQPAPQARRSWLTQQAWLAWKSHASTPIITP
                     LPA"
     misc_feature    101..655
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    101..655
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    668..943
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    668..943
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    671..694
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    671..694
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    716..745
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    716..745
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    order(725..727,731..733,812..817,821..829,845..847,
                     851..853)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(725..727,731..733,812..817,821..829,845..847,
                     851..853)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(746..754,836..838,911..913)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    order(746..754,836..838,911..913)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    758..775
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    758..775
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    782..793
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    782..793
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    803..829
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    803..829
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    836..868
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    836..868
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    887..910
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    887..910
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    929..940
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    929..940
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     exon            99..395
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            396..668
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            669..944
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1082
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1234
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaggaaa gacttacaca atgtcctgac accacgtcct gacaccatgt ggtctctgat
       61 cttctgcttc ctgagccacc cccaagacac tggagcccga tcacactctc tgcactattc
      121 ttactcagcc gtgacagagc cgggcccagg agttcctgca ttttttgcca gtggctttgt
      181 agataaccag cccttcatcc actatgacag taggaagatg gaggcagagc cttgtgctga
      241 ctggctgagg gaaaatccat attactttga tgaggagacc caggttttca ccaatcggat
      301 gaagatcttc cagttgagcc tgagaaacat tcagcaatac tacaacagct ctggtgaccg
      361 gagtcagaga gcagacggct tccaccagca agcaggccct cacaccctcc agttcacgta
      421 cggctgtgag atgcagggca acaggaccac agggcactgg cagtatggct atgatggcag
      481 agattacctg accttggact tggactctat ggaatataca gcagccacct tcattgctgg
      541 ctacaccaag cacaagtggc aaaacaatga gtactggctg gagagagaga agacctactt
      601 ggagaaggag tgtgtcctgt ggctaaagag atacttaact atgggaggag agaactttac
      661 ccgaactgac cctccacaga caacagtgac acaccacccc agacctgaag gtgatgtcac
      721 cctgaggtgc tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa
      781 tggggaggac ctgacccagg acatggagct tgtggagacc aggcctacag gggatggaac
      841 cttccagaag tgggcagctg tggtggtgcc tcttgggaag gagcagaagt acacatgcca
      901 tgtggagcat gaggggctgc ctgagccgct tacccagaga tgggaggctc ctccaggcac
      961 tgactccaac atgggaatca atgttattgc tgttgttctt caagctgtgg ccatcattgc
     1021 agctgtggcc atcatcatag ttactgttgt gaggaggagg aggaggagga ggagaaacac
     1081 aggtggggaa ggagactaca cccctgctcc tcgcagcctt tccattttta tccagcctgc
     1141 accccaagcc cgcaggagct ggctaaccca gcaagcctgg ctggcgtgga agtctcatgc
     1201 ctcaaccccc atcatcacac ctctgcctgc ctag
//
LOCUS       NM_001099649            2589 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 23 (Vom2r23), mRNA.
ACCESSION   NM_001099649 XR_008771
VERSION     NM_001099649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Jul 26, 2007 this sequence version replaced XR_008771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  72816251-72816465   c
            216-507             JAXUCZ010000001.1  72800235-72800526   c
            508-1314            JAXUCZ010000001.1  72798292-72799098   c
            1315-1540           JAXUCZ010000001.1  72797417-72797642   c
            1541-1542           JAXUCZ010000001.1  72797415-72797416   c
            1543-1666           JAXUCZ010000001.1  72789349-72789472   c
            1667-2522           JAXUCZ010000001.1  72783611-72784466   c
            2523-2589           JAXUCZ010000001.1  72783544-72783610   c
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2589
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="vomeronasal 2 receptor, 23"
                     /db_xref="GeneID:308303"
                     /db_xref="RGD:1560836"
     CDS             1..2589
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 23"
                     /protein_id="NP_001093119.1"
                     /db_xref="GeneID:308303"
                     /db_xref="RGD:1560836"
                     /translation="MLLFWIFISCFLQTPILLCSYRSSECLVKINYRLKGKGNMVIIG
                     FFPAFAVYPINKTTDWRMMRFNRDFMVEFKLRNYQCILAMMFAIEEINNNPFLLPNTS
                     LGFEVNNVPHGQRNTLATLFGSLSGSDNAIPNCGSARESNPTAVLTGPSWAISEYIGT
                     LLDLYKFPQLTFGPFDSQLGEQRRFSSLYQVAPKDTSLTVGIVSLMLHFHWIWVGLFI
                     IDDDKGAQTLSDLRSEMDKNRVCTAFVEMIVVSKGSYFTKSWKNQVQILESSANVIII
                     YGDSDSLLSLIVNIKQKLLTWKVWVLISQWDVSKFDDYFMVDSLHGALIFSHHREDIP
                     NFTDFMQKSNPSKFPEDTYLHVLWHIFFNCSFVNTDCKIVHNCLPNASLGLLPGNIFD
                     MVMSEESYNVYNAVYAVAHSLHEMILNQVQFQPHEKGKKTIFFPWLLHPFLRKTQFIS
                     HDGANMVLDFKRKSHIDYDIVNFWNFPKGLGLNVKVGTFSSNAPNNHKLSISSYMIQW
                     ATGSTEIPQSVCSESCHPGFRKTHKEGSVVCCFDCISCPENEISNETDMDQCVKCPET
                     HYANTNKIYCLPKTVTFLAYDDPLGKTLCFMSLGFSSLTAAVLWVFLKNRDTPIVKAN
                     NLALSYTLLITLMLCLLCPLLFIGHPSTASCILQQNIFGLLFTVSLSTVLAKTITVVI
                     AFKITSPGRIRRWLLISRAPNFIIPLCTLLQVFLSAIWLTTSPPFIDKDAQSEHGHII
                     IICNKGSAVAFHCNLGYLGALALVSYFMAFLSRNLPDTFNEAKFLAFSMLVFCSVWIT
                     FLPIYHSTKGKTTVAMEVFSILASGTSLLGIIFAPKCYIILLRPERNSLHYIRDKKYA
                     KRRKPS"
     misc_feature    121..1524
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1524
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(226..228,517..522,1192..1194)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(226..228,517..522,1192..1194)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,478..480,739..741)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(340..342,349..351,478..480,739..741)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1546..1707
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1546..1707
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1765..2520
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1765..2520
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1765..1842
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1765..1842
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1774..1776,1783..1788,1795..1800,1804..1809,
                     1909..1911,1921..1923,1930..1935,1957..1959,1969..1971)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1774..1776,1783..1788,1795..1800,1804..1809,
                     1909..1911,1921..1923,1930..1935,1957..1959,1969..1971)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1876..1941
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1876..1941
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1936..1938,1972..1977,1984..1989,1996..1998,
                     2236..2238,2251..2253,2260..2265,2272..2274,2374..2376,
                     2383..2388,2395..2397,2407..2409,2431..2436,2443..2445,
                     2452..2454,2464..2466)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1936..1938,1972..1977,1984..1989,1996..1998,
                     2236..2238,2251..2253,2260..2265,2272..2274,2374..2376,
                     2383..2388,2395..2397,2407..2409,2431..2436,2443..2445,
                     2452..2454,2464..2466)
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1966..2040
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1966..2040
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2110..2160
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2110..2160
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2239..2319
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2239..2319
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2341..2412
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2341..2412
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2425..2502
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2425..2502
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..215
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
     exon            216..507
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
     exon            508..1314
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1542
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1666
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..2589
                     /gene="Vom2r23"
                     /gene_synonym="RGD1560836"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgctct tttggatttt tatatcctgc tttctgcaga ctccaattct tctctgttcc
       61 tacagaagca gcgaatgttt agtcaagata aattaccgtt taaagggaaa aggaaatatg
      121 gtgattattg gatttttccc agcttttgct gtctatccca tcaacaaaac aactgactgg
      181 aggatgatga ggttcaacag agattttatg gttgagttta agttgaggaa ctaccaatgt
      241 attttggcca tgatgtttgc cattgaggag atcaacaata atccctttct tttacccaac
      301 acgtctttgg gatttgaggt caataatgtt ccacatggtc aaaggaacac tctagccact
      361 ctttttggct cactctcagg gtctgataat gccataccta actgtggaag tgcaagagag
      421 agcaatccta ctgctgtact tacgggacca tcgtgggcaa tatctgaata catagggaca
      481 ctgctggatc tttacaaatt tccacagctt acctttggac cttttgatag tcagctgggt
      541 gaacaaagac ggttttcttc tctgtaccaa gtggccccca aggacacatc tttgacagtt
      601 ggcattgtat ctttgatgct tcatttccac tggatctggg tggggttatt catcatagat
      661 gatgacaaag gtgcccagac actgtcagat ttgagaagtg agatggataa aaacagagtc
      721 tgcacagcat ttgtagaaat gatcgtagtc agtaaaggtt catattttac caaatcctgg
      781 aaaaatcagg tgcagatcct ggaatcatca gcaaatgtga ttattattta tggggactct
      841 gattctctat taagcttaat agtaaatatt aagcagaagt tactcacatg gaaagtgtgg
      901 gtactgatct cacagtggga tgtttctaaa tttgatgatt atttcatggt agactcattg
      961 catggagctc ttattttttc acaccatcgt gaggatattc ccaattttac agattttatg
     1021 cagaagtcca acccttccaa gttcccggaa gacacttatc ttcatgtatt gtggcacatt
     1081 ttcttcaact gctcatttgt taacacggat tgtaaaattg tgcataactg tttgcctaat
     1141 gcctccctgg ggctcttgcc tgggaacata tttgacatgg tcatgagtga agagagttac
     1201 aatgtgtaca atgctgtgta tgctgtggcc cacagtctgc atgagatgat tctcaaccaa
     1261 gtacaatttc aacctcatga aaaaggaaaa aagacgatat tcttcccttg gctgcttcac
     1321 ccatttctaa ggaaaacaca attcatcagt catgatggag caaatatggt tctggatttt
     1381 aaaaggaaat cacatataga ttatgacatt gtcaactttt ggaatttccc taaaggtctt
     1441 gggttaaatg tgaaagtagg aacgttttct tcaaatgctc caaacaacca taaattgtct
     1501 atatcttctt acatgataca gtgggccaca ggatcaacag agattcccca gtctgtatgc
     1561 agtgagagct gtcatcctgg attcaggaaa acccacaagg aaggcagtgt tgtctgttgc
     1621 tttgactgta tttcttgtcc agaaaatgag atttccaatg agacagatat ggatcagtgt
     1681 gtgaagtgtc cagaaactca ctatgcaaac acaaacaaga tctactgcct accaaaaact
     1741 gtgacatttc tggcctatga tgacccatta gggaagacac tttgcttcat gtccctgggt
     1801 ttctcctcac tcacagctgc tgttctttgg gtgtttctga agaacaggga cacccccatt
     1861 gtcaaggcca ataacctggc tctcagttac accctgctca tcactttgat gctctgtctt
     1921 ctctgtccct tgctcttcat tggccatccc agcacagcct cctgtatcct gcagcaaaac
     1981 atttttgggc ttctcttcac tgtgtctctt tccactgtgt tggccaaaac tatcactgtg
     2041 gttatagcct tcaagatcac ttctccagga agaattagaa gatggctgct gatatcaagg
     2101 gcccctaatt tcattattcc cttatgcacc ttgctccaag tttttctttc tgcaatttgg
     2161 ctgacaacct ctcctccatt tattgataaa gatgctcagt cagaacatgg acacatcatc
     2221 atcatttgca ataaaggctc agctgttgct ttccattgca accttggata cctgggagca
     2281 ctagccctag tgagctactt tatggctttc ttgtccagaa acctacctga cacattcaat
     2341 gaagccaagt tcctggcttt cagcatgctg gtgttctgca gtgtctggat cacttttctc
     2401 cctatctacc atagcaccaa ggggaagacc acagtggcta tggaagtctt ctctatcttg
     2461 gcttctggta catcgctctt aggcatcatc tttgccccaa agtgctacat catattatta
     2521 aggccagaaa gaaactcact tcattatatc agggacaaaa aatatgctaa gagaagaaaa
     2581 ccttcttaa
//
LOCUS       NM_001099499            2559 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 63 (Vom2r63), mRNA.
ACCESSION   NM_001099499 XM_001075977 XM_221987
VERSION     NM_001099499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000012.1.
            
            On or before Aug 17, 2007 this sequence version replaced
            XM_221987.4, XM_001075977.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000012.1  22738778-22738977
            201-492             JAXUCZ010000012.1  22755451-22755742
            493-1299            JAXUCZ010000012.1  22756530-22757336
            1300-1530           JAXUCZ010000012.1  22758496-22758726
            1531-1662           JAXUCZ010000012.1  22759170-22759301
            1663-2559           JAXUCZ010000012.1  22765547-22766443
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2559
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="vomeronasal 2 receptor, 63"
                     /db_xref="GeneID:288541"
                     /db_xref="RGD:1564022"
     CDS             1..2559
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 63"
                     /protein_id="NP_001092969.1"
                     /db_xref="GeneID:288541"
                     /db_xref="RGD:1564022"
                     /translation="MPTWIFFFFTLKLPMFLCKLLTHECFVSSTDNIYQDGDLVISAF
                     LPLYTYQTSQHTEGAESIDVSPRITSQNYQFVMALIFAIDEINRNPILLPNMTLGYNI
                     HSAGSIESETVVSFLKWLTGQDRLIPNYTCKTKEKSVAAITGTTWEISSLIGIFLGLY
                     KYPQLSIGPFEPSMNNSEKFPFLYQMAAKESSLALGMVSMFVHFKWNWVGLVISEDEN
                     GVNFVTDLIPQMERNTICVAFMEFITVTHMMDLENAYEYPIRIMRNPAKVVIIYANTD
                     TSLGVLFRRWEYILPWRIWVTTSQWEVVTSMRHLILDSFHGTLIFSQRQGDISTFKEF
                     VKTVRPSKYPDDIFLARLWEIYFDCAISNATCKSLENCSSRGNLGLLPWYHFDIAVST
                     GSYHVYNAVYAVAHTMHKMLIQEIDIQGVKNGGSMDFPPLKLNSLLKNIKFMNPGGDP
                     ISLNPSEKLHIDYDILNFWDFPQGLTYKVKVGTFSPYFPPGQQLSISEDRIEWSIGVE
                     QQIPASVCSESCGPGFRKSLQEEKAACCFDCVPCPENEISNGTGKCCVKCTEDQYANT
                     DRTVCIQKAVTFLAFENPLGMTLASMALCFSILTSFVLGIFVKHQSTLVVKANNSTLS
                     YILLISLTFCFLCSFLFIGQPNAVTCILQQTTFGVVFTVAVSTVLAKTTTVILAFKST
                     APGRRLRGLLISGASKFIIPICTLIQIVLCGIWLGISPPFVDTDAHSEHGHIIIMCNK
                     GSVTAFYCVLGYLGALSLVSFTVAFMARNLPDIFNEAKFLTFSMLVFLSVWITFFPVY
                     HSTKGKIMVAVEVFSILASSTGLLGCIFIPKCYIILARPDMNSLKCRRNRVQWK"
     misc_feature    118..1509
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1509
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1692
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1692
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1750..2502
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..2502
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..200
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
     exon            201..492
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1299
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1530
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1662
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..2559
                     /gene="Vom2r63"
                     /gene_synonym="RGD1564022"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccactt ggattttttt cttttttacc ctcaagcttc ctatgttctt gtgcaaattg
       61 ctcacccatg agtgttttgt ttcttccaca gacaatatat accaggatgg ggatttggtg
      121 atcagtgcgt tcttacccct ttatacctat caaacctccc aacacactga aggggcagag
      181 agcatagatg tcagtccacg gattacctca caaaactacc aatttgtgat ggccttaatt
      241 tttgccatag atgagatcaa cagaaacccc attcttttac ctaacatgac gcttggatat
      301 aatattcaca gtgctgggtc cattgaaagt gagacagtag taagtttcct caagtggctc
      361 acagggcagg acagactcat tccaaactat acatgcaaaa ccaaggaaaa atctgtggct
      421 gcaatcacag gaacaacatg ggaaatttct tccttaattg gcatattttt gggtctttat
      481 aaatatccac agctgagcat tggaccattt gaaccaagta tgaataactc tgagaagttt
      541 ccttttttgt atcagatggc tgccaaagaa tcttctttgg ccttaggcat ggtctcaatg
      601 tttgtccatt tcaaatggaa ttgggtgggg ctggtcatct cagaggatga gaatggtgtt
      661 aactttgtca cagacttgat tccacaaatg gaaagaaaca caatctgtgt agccttcatg
      721 gaatttatca cagttactca catgatggac ctggaaaacg cttatgaata ccctattcgg
      781 attatgagaa acccagccaa agttgttatc atttatgcta acactgacac ttccttagga
      841 gtgctgttta gaagatggga atatatactt ccatggagaa tctgggtgac cacttcacag
      901 tgggaagtcg tcacttctat gagacattta attcttgact cattccatgg gactctcatc
      961 ttttcacaac gccagggtga tatttctact tttaaagagt ttgtaaagac agtgagacct
     1021 tccaaatacc cagatgacat ttttcttgca agactgtggg agatttactt tgattgtgca
     1081 atatccaacg ctacctgtaa atcattagaa aattgttcct ctagaggtaa cttgggattg
     1141 ttaccttggt accactttga catagctgta agtactggca gttaccacgt atacaatgct
     1201 gtgtatgctg tggcccacac catgcacaag atgcttattc aagaaataga catacaagga
     1261 gtgaaaaatg gaggcagcat ggatttcccc cccttgaagc tgaactccct gctgaagaac
     1321 attaaattca tgaatcctgg tggagatcca atatctttga atccttcaga gaaattgcac
     1381 atagattatg acattctgaa cttctgggat tttccacaag gtcttacata taaagtgaaa
     1441 gtaggaacat tttctccata ttttccacct ggtcaacaat tgtcgatttc tgaggatagg
     1501 atagagtgga gcataggagt ggagcaacag attcctgcct ctgtatgcag tgaaagttgt
     1561 ggtcctggat tcagaaaatc tcttcaggaa gagaaagccg cttgctgttt tgattgtgtc
     1621 ccatgtccag aaaatgaaat ttccaatgga acaggcaagt gctgtgtgaa atgtacagag
     1681 gaccagtatg ccaacacaga tcggactgtc tgcatccaaa aagctgtaac atttcttgct
     1741 tttgaaaacc ccttggggat gacactcgcc agcatggccc tatgcttttc tatcctcacc
     1801 tcatttgtcc tggggatttt tgtaaagcac caaagcactc ttgtggtgaa ggcaaataac
     1861 agtactctca gctacatctt gctcatctcc ctcaccttct gctttctttg ctcatttcta
     1921 ttcattggtc agcccaacgc agtcacctgc atcctgcagc agaccacatt tggagttgtt
     1981 ttcacagtgg ctgtttctac tgtcttggca aaaaccacta cagtcatcct ggccttcaag
     2041 agcacagctc caggaagaag gttgaggggg ttacttatat caggagcatc gaaattcatc
     2101 attcccatct gtacactaat acaaattgtc ctctgtggaa tctggctggg aatatctcct
     2161 ccatttgtgg acacagatgc acactctgaa catggtcata tcattattat gtgcaacaag
     2221 ggctcagtaa cagccttcta ctgtgtgctg ggataccttg gagctctgtc cctagtgagc
     2281 ttcacagtag cttttatggc caggaacctg cctgacatct tcaatgaagc caaattcttg
     2341 accttcagca tgctggtatt tctcagtgtt tggattacat ttttccctgt ctaccacagt
     2401 actaaaggaa agatcatggt ggctgtggaa gtattctcca tcttggcctc cagcacaggt
     2461 cttctaggtt gtatctttat ccccaaatgt tatatcattc ttgcaagacc tgacatgaac
     2521 tcattgaaat gcagacgaaa tagagttcag tggaaataa
//
LOCUS       NM_001191885            1261 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 like
            (Gpd1l), mRNA.
ACCESSION   NM_001191885 XM_343498
VERSION     NM_001191885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Liu,M., Sanyal,S., Gao,G., Gurung,I.S., Zhu,X., Gaconnet,G.,
            Kerchner,L.J., Shang,L.L., Huang,C.L., Grace,A., London,B. and
            Dudley,S.C. Jr.
  TITLE     Cardiac Na+ current regulation by pyridine nucleotides
  JOURNAL   Circ Res 105 (8), 737-745 (2009)
   PUBMED   19745168
  REMARK    GeneRIF: Mutations of GPD1-L may downregulate Na(v)1.5 by altering
            the oxidized to reduced NAD(H) balance.
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Valdivia,C.R., Ueda,K., Ackerman,M.J. and Makielski,J.C.
  TITLE     GPD1L links redox state to cardiac excitability by PKC-dependent
            phosphorylation of the sodium channel SCN5A
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (4), H1446-H1452 (2009)
   PUBMED   19666841
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   London,B., Michalec,M., Mehdi,H., Zhu,X., Kerchner,L., Sanyal,S.,
            Viswanathan,P.C., Pfahnl,A.E., Shang,L.L., Madhusudanan,M.,
            Baty,C.J., Lagana,S., Aleong,R., Gutmann,R., Ackerman,M.J.,
            McNamara,D.M., Weiss,R. and Dudley,S.C. Jr.
  TITLE     Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L)
            decreases cardiac Na+ current and causes inherited arrhythmias
  JOURNAL   Circulation 116 (20), 2260-2268 (2007)
   PUBMED   17967977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_343498.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211779.1, FQ217318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000008.1  123498697-123498948 c
            253-430             JAXUCZ010000008.1  123488850-123489027 c
            431-571             JAXUCZ010000008.1  123485839-123485979 c
            572-710             JAXUCZ010000008.1  123483514-123483652 c
            711-823             JAXUCZ010000008.1  123480035-123480147 c
            824-1057            JAXUCZ010000008.1  123471645-123471878 c
            1058-1164           JAXUCZ010000008.1  123470565-123470671 c
            1165-1261           JAXUCZ010000008.1  123469282-123469378 c
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /note="glycerol-3-phosphate dehydrogenase 1 like"
                     /db_xref="GeneID:363159"
                     /db_xref="RGD:1560123"
     exon            1..252
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    77..79
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /note="upstream in-frame stop codon"
     CDS             206..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /EC_number="1.1.1.8"
                     /note="glycerol-3-phosphate dehydrogenase 1 like 1"
                     /codon_start=1
                     /product="glycerol-3-phosphate dehydrogenase 1-like
                     protein"
                     /protein_id="NP_001178814.1"
                     /db_xref="GeneID:363159"
                     /db_xref="RGD:1560123"
                     /translation="MAAAPLKVCIVGSGNWGSAVAKIIGSNVKNLQKFSSTVKMWVFE
                     ETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQDADLLVFVIPHQFIHK
                     ICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAA
                     EKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDG
                     LCCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFLESCGVADLITTCYGGRNRKVA
                     EAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYEG
                     RPVTQMLSCLQSHPEHI"
     misc_feature    224..1237
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /note="glycerol-3-phosphate dehydrogenase (NAD(+));
                     Region: glycerol3P_DH; TIGR03376"
                     /db_xref="CDD:274551"
     misc_feature    224..1237
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /note="glycerol-3-phosphate dehydrogenase (NAD(+));
                     Region: glycerol3P_DH; TIGR03376"
                     /db_xref="CDD:274551"
     exon            253..430
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            431..571
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            572..710
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            711..823
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1057
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1164
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctaggcgc ctaggcgggt ggcggtggcc attggcggac aggagggcgg ggcggggtcg
       61 cccggagcgg ctatactagg ccgttccagt ggaggtgagc agccggcccg ggaggcactg
      121 tgtgtgctgc agcgatccgg cttgcagcag cgatccggct tggccctggg aggaaggctg
      181 tgtacagcag ctacccggct tggccatggc agcggcgcct ctgaaagtgt gcatcgtggg
      241 ctccgggaac tggggatcag ctgttgcaaa aatcatcgga agcaatgtga agaacctgca
      301 gaagttctcc tccacggtca agatgtgggt cttcgaagag actgtgaacg ggaggaagtt
      361 gacagacatc atcaacaatg accacgaaaa tgtgaaatat ctcccgggac acaagctacc
      421 agaaaatgtg gtcgctgtcc caaatctcgg cgaagccgtg caggacgcag acctgttggt
      481 gttcgttatc ccccaccagt tcattcacaa gatctgcgat gagatcacgg gcagggtgcc
      541 caagaaggcc gtgggaatca ccctcatcaa gggtatagat gagggcccgg acgggctgaa
      601 gctcatctcc gacatcatcc gggagaagat ggggattgac atcagtgtgc tgatgggggc
      661 caacatcgcc agcgaggtcg ctgcggagaa gttctgcgag accaccattg gcagcaaagt
      721 gttgcagaac ggccttctct tcaaagagct gctgcagacg cccaatttca gaatcacggt
      781 ggtggatgat gcagacaccg tggaactctg cggtgctctt aagaacattg ttgctgtggg
      841 agccggcttc tgcgatggcc tctgctgtgg ggacaacacc aaggcagccg tcatccgcct
      901 gggcctcatg gaaatgatcg ctttcgccaa gatcttctgt aagggccagg tgtccacggc
      961 caccttcttg gagagctgcg gggtggccga cctcatcacc acctgctacg gagggcggaa
     1021 ccgcaaggtg gcagaagcct tcgccaggac cgggaagacc atcgaagagc tggagaagga
     1081 gctgctgaac ggacagaagc tccagggacc tcagacctct gcggaggtgt accgcatcct
     1141 caagcagaag gggctgctgg acaagtttcc cctcttcact gccgtgtatc agatctgcta
     1201 tgaaggcaga cctgtcaccc agatgctgtc ctgcctgcag agccacccgg agcacatctg
     1261 a
//
LOCUS       NM_001135715            2764 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 67 (Trim67), mRNA.
ACCESSION   NM_001135715 XM_226563
VERSION     NM_001135715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Yaguchi,H., Okumura,F., Takahashi,H., Kano,T., Kameda,H.,
            Uchigashima,M., Tanaka,S., Watanabe,M., Sasaki,H. and Hatakeyama,S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Oct 8, 2008 this sequence version replaced XM_226563.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              JAXUCZ010000019.1  69661777-69663238
            1463-1558           JAXUCZ010000019.1  69683456-69683551
            1559-1681           JAXUCZ010000019.1  69685341-69685463
            1682-1792           JAXUCZ010000019.1  69686728-69686838
            1793-1946           JAXUCZ010000019.1  69688188-69688341
            1947-2092           JAXUCZ010000019.1  69690826-69690971
            2093-2231           JAXUCZ010000019.1  69692280-69692418
            2232-2535           JAXUCZ010000019.1  69693455-69693758
            2536-2698           JAXUCZ010000019.1  69695999-69696161
            2699-2764           JAXUCZ010000019.1  69697739-69697804
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2764
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="tripartite motif-containing 67"
                     /db_xref="GeneID:307938"
                     /db_xref="RGD:1560667"
     exon            1..1462
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    353..355
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="upstream in-frame stop codon"
     CDS             452..2764
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /codon_start=1
                     /product="tripartite motif-containing protein 67"
                     /protein_id="NP_001129187.1"
                     /db_xref="GeneID:307938"
                     /db_xref="RGD:1560667"
                     /translation="MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGEQH
                     LPPPLLLSRGAAAAAAAPPPDQDAAAGATCGGAGASTAGGLGGGAAGGGDHADKLSLY
                     SETDSGYGSYTPSLKSPNGVRVLPMVPAPPGSSAAAARGAACSSLCSSSSSITCPQCH
                     RSASLDHRGLRGFQRNRLLEGIVQRYQQGRGVAAGASAAPAVAICQLCDRTPPEPAAT
                     LCEQCDVLYCATCQLKCHPSRGPFAKHRLVQPPPPPAPPEATSASVGTSTASSAGGCR
                     SPGGAGAPVPRKFPTCPEHEMENYSMYCVSCRSPVCYMCLEEGRHGKHEVKPLGATWK
                     QHKAQLSQALNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTR
                     QKAKLLTKVTKEREQKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKEDDPSGFLQISD
                     ALIKRVQTSQEQWVKGALEPKVSAEFDLTLDSEPLLQAIHQLDFVQMKLPPVPLLQLE
                     KCCTRNNSATLAWRTPPFTHSPADGYILELDDGDGGQFREVYVGKETLCTIDGLHFNS
                     TYNARVKAFNSSGVGPYSKTVVLQTSDVAWFTFDPNSGHRDIILSNDNQTATCSSYDD
                     RVVLGTAAFSKGAHYWELHVDRYDNHPDPAFGVARASVVKDMMLGKDDKAWAMYVDNN
                     RSWFMHCNSHTNRTEGGVCKGATVGVLLDLNKHTLTFFINGQQQGPTAFSHVDGVFMP
                     ALSLNRNVQVTLHTGLEVPTNLGRPKLSGN"
     misc_feature    455..>592
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: RING-HC_TRIM67; cd16758"
                     /db_xref="CDD:438416"
     misc_feature    455..>592
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: RING-HC_TRIM67; cd16758"
                     /db_xref="CDD:438416"
     misc_feature    1061..1198
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: Bbox1_TRIM67_C-I; cd19844"
                     /db_xref="CDD:380902"
     misc_feature    1061..1198
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: Bbox1_TRIM67_C-I; cd19844"
                     /db_xref="CDD:380902"
     misc_feature    1319..1453
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: Bbox2_TRIM67_C-I; cd19827"
                     /db_xref="CDD:380885"
     misc_feature    1319..1453
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 67 (TRIM67) and similar proteins;
                     Region: Bbox2_TRIM67_C-I; cd19827"
                     /db_xref="CDD:380885"
     misc_feature    1457..1837
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1457..1837
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1994..2224
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1994..2224
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(2189..2194,2198..2203)
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(2189..2194,2198..2203)
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2213..2728
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2213..2728
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            1463..1558
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1681
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1792
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1946
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2092
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2231
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2535
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2698
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2764
                     /gene="Trim67"
                     /gene_synonym="RGD1560667"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcgggg cgctcgcaga aggaagactc ggggcagcgg cgctgcggag cccggctcag
       61 tagccttgct ggctcacagc agcgagtcac tggtccttcg tagagtggag gcacgaggta
      121 cccctgacgg cgctgctgct gcctattcac cacctggaca acctcggagg ccactgcgag
      181 ggctgctggc caccttcata cggccgcctc tggtgaggga gcctcgccct caggaggtga
      241 ggacccctcc tttctctggc ggccaagcgt cttagggcgg tggcctgagg acagagaggg
      301 ggcgtgccac cctcgggtga agacagcatg cccgtgtaat acccccgcct cctgactcaa
      361 gagcgctgac atcgcctgcc cagctgcgct tgtcttcgga gctttgacca tccttggctg
      421 gtcccgagcg gctctggccg cgggcgcggc gatggaggag gagctgaagt gcccagtgtg
      481 cggatccctg ttccgggagc ccatcatcct gccctgttct cacaatgtct gcttgccgtg
      541 cgcccgcacc atcgcggttc agaccccgga cggcgagcag cacctgcccc cgccgctcct
      601 tctttcgcgg ggtgccgccg ccgccgccgc cgcgccccct ccggatcagg atgcagcggc
      661 cggcgcgacc tgcggaggcg ccggagctag tacagccgga ggcctgggcg gcggggcggc
      721 cggtggcgga gaccacgcgg acaagctgag cttgtatagc gagactgaca gcggctatgg
      781 ctcctacacc cccagcctca agtcccccaa tggagtccgc gtgctgccca tggtgcctgc
      841 gcctccgggt tcatctgccg ccgcggcccg aggcgccgcc tgctcctcgc tctgctcgtc
      901 ctccagctcc atcacctgcc cgcagtgcca ccgcagcgcc tccctggatc accgcggcct
      961 gcgaggcttc cagcgcaacc ggctactgga gggcatcgtg cagcggtacc agcagggccg
     1021 tggggttgct gcgggggcat ctgcagcccc ggcggtggcc atctgccagc tgtgcgaccg
     1081 caccccaccg gagccggcag ccactctctg cgagcaatgc gacgtgctct attgcgccac
     1141 ctgccagctc aagtgccacc cgtcccgggg ccccttcgct aagcatcggc tagttcagcc
     1201 gccgccgccg cccgcacccc cagaggctac ctctgcttca gtcggtactt ccaccgcctc
     1261 cagcgcagga ggatgcagga gcccaggggg tgccggggcc cccgtgcctc gaaagttccc
     1321 cacgtgcccg gagcacgaga tggagaacta cagcatgtac tgcgtgagct gtcggagccc
     1381 ggtgtgctac atgtgcctag aggaaggcag gcatggcaag cacgaggtga agccgctggg
     1441 ggcaacgtgg aaacagcaca aggcccagct gtctcaggcc ttaaacgggg tttcagacaa
     1501 ggccaaagag gcgaaggagt tcctggttca gctcaagaac atactgcagc agatccagga
     1561 aaatggactg gactatgaag cctgcctggt ggcccagtgt gacgccctgg tggacgccct
     1621 gactcggcag aaagccaagc tgctcaccaa ggtcaccaag gagagggaac agaagctgaa
     1681 gatggtttgg gaccagatca accactgcac tctgaagctg cgccagtcca ctggcctgat
     1741 ggagtactgc ctggaggtga tcaaggagga cgacccctct gggttcctgc agatctcaga
     1801 cgccctgatc aagcgtgtgc agacctcaca ggagcagtgg gtcaaaggtg ccctggagcc
     1861 caaagtgtct gcggagttcg acctgaccct ggacagcgag ccgctgctgc aagccatcca
     1921 ccagctggat ttcgtccaga tgaaattgcc acctgtaccc ctgctgcagc tggagaagtg
     1981 ctgcacccgt aataacagcg ccaccctggc ctggaggacc ccgcccttca cccacagccc
     2041 tgctgatggc tacatcctgg agctggatga tggcgacgga gggcagttcc gggaagtgta
     2101 cgtcggcaag gagaccctgt gcaccatcga cgggctccac tttaacagca cctacaatgc
     2161 cagagtgaaa gccttcaact cctctggtgt tgggccctac agcaagactg tggtcctgca
     2221 gacctctgac gtggcctggt tcactttcga ccccaactct ggccatcggg acatcatctt
     2281 atctaacgac aaccagacag ccacctgtag cagctatgac gaccgggtgg tgctaggcac
     2341 agctgcattc tccaaaggtg cgcactactg ggagctgcac gtcgaccggt acgacaacca
     2401 cccagaccca gccttcgggg tggccagggc cagcgtggtc aaggacatga tgctgggtaa
     2461 agacgacaag gcctgggcca tgtacgtgga caacaaccgc agctggttca tgcactgcaa
     2521 ctcccacacc aacaggaccg aaggcggtgt atgcaagggg gccactgtgg gcgtgctgct
     2581 ggacctgaac aagcacactc tgaccttctt catcaacggg caacaacagg gccccacagc
     2641 cttcagccac gtggatgggg tcttcatgcc tgccctcagc ctcaaccgaa acgtgcaggt
     2701 caccctgcac acaggactgg aggtgccaac aaacctagga cggccaaagc tgtcaggcaa
     2761 ctag
//
LOCUS       NM_001128216            1002 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus cathepsin 8 (Cts8), mRNA.
ACCESSION   NM_001128216 XM_001058557
VERSION     NM_001128216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jun 10, 2008 this sequence version replaced XM_001058557.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000017.1  3474333-3474458
            127-249             JAXUCZ010000017.1  3474729-3474851
            250-396             JAXUCZ010000017.1  3474943-3475089
            397-621             JAXUCZ010000017.1  3477068-3477292
            622-784             JAXUCZ010000017.1  3477727-3477889
            785-902             JAXUCZ010000017.1  3485445-3485562
            903-1002            JAXUCZ010000017.1  3486405-3486504
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1002
                     /gene="Cts8"
                     /note="cathepsin 8"
                     /db_xref="GeneID:680718"
                     /db_xref="RGD:1588248"
     CDS             1..1002
                     /gene="Cts8"
                     /codon_start=1
                     /product="cathepsin 8 precursor"
                     /protein_id="NP_001121688.1"
                     /db_xref="GeneID:680718"
                     /db_xref="RGD:1588248"
                     /translation="MSPVVLLAILCLGVARATQPSDPSLDSEWQEWKTKYEKNYSLEE
                     EGQKRAVWEENMKVVKQHNIEYDQEKKNFTMELNAFADMTGEEFRKMMTNIPVQNLRK
                     KKSIHQPIFRYLPKFVDWRRRGYVTSVKNQGTCNSCWAFSVAGAIEGQMFRKTGRLVS
                     LSPQNLVDCSRPEGNHGCHMGSTLYALKYVWSNGGLEAESTYPYEGKEGPCRYLPRRS
                     AARVTGFSTVARSEEALMHAVATIGPISVGIDASHVSFRFYRRGIYYEPRCSSNRINH
                     SVLVVGYGYEGRESDGRKYWLIKNSHGVGWGMNGYMKLARGWNNHCGIATYGFYPRV"
     sig_peptide     1..51
                     /gene="Cts8"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    85..261
                     /gene="Cts8"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     Region: Inhibitor_I29; smart00848"
                     /db_xref="CDD:214853"
     misc_feature    85..261
                     /gene="Cts8"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     Region: Inhibitor_I29; smart00848"
                     /db_xref="CDD:214853"
     misc_feature    343..993
                     /gene="Cts8"
                     /note="Peptidase C1A subfamily (MEROPS database
                     nomenclature); composed of cysteine peptidases (CPs)
                     similar to papain, including the mammalian CPs (cathepsins
                     B, C, F, H, L, K, O, S, V, X and W). Papain is an
                     endopeptidase with specific substrate preferences; Region:
                     Peptidase_C1A; cd02248"
                     /db_xref="CDD:239068"
     misc_feature    343..993
                     /gene="Cts8"
                     /note="Peptidase C1A subfamily (MEROPS database
                     nomenclature); composed of cysteine peptidases (CPs)
                     similar to papain, including the mammalian CPs (cathepsins
                     B, C, F, H, L, K, O, S, V, X and W). Papain is an
                     endopeptidase with specific substrate preferences; Region:
                     Peptidase_C1A; cd02248"
                     /db_xref="CDD:239068"
     misc_feature    order(394..396,412..414,826..828,898..900)
                     /gene="Cts8"
                     /note="active site"
                     /db_xref="CDD:239068"
     misc_feature    order(394..396,412..414,826..828,898..900)
                     /gene="Cts8"
                     /note="active site"
                     /db_xref="CDD:239068"
     misc_feature    order(544..549,742..744,820..822,829..831,979..981)
                     /gene="Cts8"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     misc_feature    order(544..549,742..744,820..822,829..831,979..981)
                     /gene="Cts8"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     exon            1..126
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            127..249
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            250..396
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            397..621
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            622..784
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            785..902
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1002
                     /gene="Cts8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtcctg ttgtcctgct ggccatcctg tgcttgggag tagccagagc tactcaacca
       61 tctgatccca gtttggattc tgaatggcag gagtggaaga caaagtatga gaaaaactac
      121 agcctggagg aagaaggaca gaagagagca gtatgggaag aaaacatgaa agtggtcaaa
      181 cagcataata ttgaatatga tcaggaaaag aaaaacttta ccatggaact caatgcattt
      241 gctgacatga ctggtgagga attcaggaaa atgatgacta atatcccagt ccagaatctt
      301 aggaagaaga aaagtatcca tcaacctatt tttcgttatc taccgaaatt tgtagactgg
      361 agaagaagag gctatgtgac ttctgtgaag aatcagggca catgtaattc ttgttgggct
      421 ttttctgtgg ctggtgccat agaaggacag atgttccgga agactggcag actggtctca
      481 ctgagtccac aaaatctagt ggactgttct agacctgaag ggaatcatgg ctgtcatatg
      541 ggcagtacgc tctatgcttt aaagtatgta tggagtaatg gaggtctgga ggctgagtca
      601 acttatccat atgaaggaaa ggaaggaccc tgccggtacc tcccaagacg ttctgctgct
      661 agagtcacag gcttttctac tgtagcaaga agtgaggaag ccttaatgca tgctgtagca
      721 actatagggc ccatctctgt tggaattgat gcttcacatg tatctttcag gttctatagg
      781 agaggcattt attatgagcc aaggtgtagt agtaatcgta tcaaccattc tgttctggta
      841 gtcggctatg gctatgaagg aagagaatca gatggcagga aatattggct gataaaaaac
      901 agtcatggtg taggatgggg catgaatggc tacatgaagc ttgccagagg ctggaacaac
      961 cactgtggaa ttgctacata tggcttttat cccagagtgt ga
//
LOCUS       NM_001099458            2526 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 4 (Vom2r4), mRNA.
ACCESSION   NM_001099458 XM_001067385 XM_218106
VERSION     NM_001099458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XM_218106.3, XM_001067385.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  2889361-2889566     c
            207-489             JAXUCZ010000001.1  2886516-2886798     c
            490-1293            JAXUCZ010000001.1  2885325-2886128     c
            1294-1518           JAXUCZ010000001.1  2884144-2884368     c
            1519-1642           JAXUCZ010000001.1  2876535-2876658     c
            1643-2526           JAXUCZ010000001.1  2874499-2875382     c
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..2526
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="vomeronasal 2 receptor, 4"
                     /db_xref="GeneID:308248"
                     /db_xref="RGD:1564110"
     CDS             1..2526
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="vomeronasal type-2 receptor 116-like"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 4 precursor"
                     /protein_id="NP_001092928.1"
                     /db_xref="GeneID:308248"
                     /db_xref="RGD:1564110"
                     /translation="MKKMWAFTIAFFSLKFCLILCSLTEPSCFWRIKRSEDNDGDLRS
                     DCGFVLFTLESPIEENFYTRIINFRIPARKYEFFLVLFFAIDEINKNPYLLSNMSLIF
                     SIIVGLCEDTMGVLDKAYSHQSKIFKRINYFCGIKQRCDINLTGPSWTTSLKLSIYSR
                     TPKIFFGSFNPNLSDHDQFPYIYQRANKDTYLFCGMVSLMFHFGWTWIGLVISNDDQG
                     IQFLSDLREEMQRHAICLAFVIMIPETMQIYKTRVKIYDQQLMTSSAKVVVIYGEMNS
                     TLELSFRRWAYLGAQRIWITTSQWDVITNQKDFSLDFSHGTVTFAHHHNDITIFRNFM
                     QTINTSKYPIDISQSMLQWNHFNCSISKNKKKMDCFTFNNPLEWLVQHTFDMVLSEEG
                     YNLYNAVYAVAHTYHELIFQQAESQKMADPKGVFTDCQQVASLLKTRVFINPVGELVN
                     MNHKENYCAKYDIFIIWYFPQGLGLKVKIGSYFPCLPQSQQLHISEDWEWVTEETLVP
                     SSVCSVTCTAGFRKIHQKQTADCCFDCVQCQENEIANDTDMEHCVRCPEDSYANLEQT
                     ECLQRVVTFLAYEDPLGMALGCMALSFSAITILVLVTFVKYRDTPIVKANNRILSYIL
                     LISLAFCFLCSLLFIGHPNQATCILQQTTFAIFFTVAISTVLAKTITVVTAFKLTTPG
                     RRIRKMMIKGAINLLIPICTLIQLVLCAIWLVTSPPFIDRDIQSEHGKIIIICNKGSV
                     IAFHIVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYHST
                     RGKVMVVVEVFSILASSAGLLGCIFVQKCYVLLVQPDLNVLQK"
     sig_peptide     1..78
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    133..1500
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    133..1500
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1522..1683
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1522..1683
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1741..2496
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1741..2496
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1741..1818
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1741..1818
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
     exon            207..489
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1293
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1518
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1642
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2526
                     /gene="Vom2r4"
                     /gene_synonym="RGD1564110"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaaga tgtgggcatt cactattgcc tttttttccc tgaagttttg tctcatcttg
       61 tgcagcttga ctgaacccag ttgcttttgg agaataaaga ggagtgaaga taatgatgga
      121 gatttgcgaa gtgactgcgg ttttgtcctt tttacactcg agagtcctat tgaagaaaat
      181 ttttatactc gcattattaa ttttaggata ccagcaagaa aatatgagtt ttttctggta
      241 ctgttttttg ctatcgatga gatcaacaag aatccttatc ttttatccaa catgtctttg
      301 atattttcca tcattgttgg cctgtgtgag gatacaatgg gagttctgga taaagcatat
      361 tcacatcaaa gcaaaatttt caaacgaatt aattatttct gtggaataaa gcaacgttgt
      421 gatataaacc tgacaggacc atcatggaca acttccttaa aactgtcaat ttattcaagg
      481 acaccaaaga ttttctttgg ctcatttaac cctaatctga gtgaccatga ccagtttccc
      541 tatatctatc agagagcaaa caaagacaca tatttgttct gtggcatggt ctccttgatg
      601 tttcattttg gatggacttg gataggactg gtcatctcaa atgatgacca aggtattcag
      661 tttctttcag acttgagaga agaaatgcaa aggcatgcaa tctgtttagc ttttgtgatt
      721 atgatcccag aaaccatgca gatatataag acaagagtta agatatatga ccaacaactt
      781 atgacatctt cagcaaaggt tgttgtcatt tatggtgaaa tgaactccac tctagaactc
      841 agctttagaa gatgggcata tttaggtgca cagagaatct ggatcacaac ctcacaatgg
      901 gatgtcatca caaaccaaaa agatttcagc cttgatttct cccatgggac tgtcactttt
      961 gcccatcacc acaatgacat cactatattt agaaatttta tgcaaacaat aaacacatcc
     1021 aagtatccaa tagacatttc gcagtctatg ctgcagtgga accattttaa ctgttcaatc
     1081 tcaaagaaca agaagaaaat ggattgtttt acgttcaaca acccattgga atggttagta
     1141 cagcacacat ttgacatggt cctgagtgaa gaaggttaca atttgtataa tgctgtgtat
     1201 gctgtggccc acacctacca tgaactcatt tttcaacaag cagagtctca gaaaatggca
     1261 gatcccaaag gagtattcac tgactgtcag caggtggctt ctttgctaaa aactagggta
     1321 tttattaacc ctgttggaga actggtaaat atgaatcata aggaaaatta ttgtgccaag
     1381 tatgacattt tcatcatttg gtattttcca caaggccttg gattaaaagt gaaaatagga
     1441 agctattttc cttgtttgcc acagagtcaa caacttcata tatctgaaga ctgggagtgg
     1501 gtcacagaag aaacactggt tccctcctca gtgtgtagtg tgacatgtac tgcaggattc
     1561 agaaaaattc atcagaaaca aacagccgac tgctgctttg attgtgtcca gtgccaagaa
     1621 aatgagattg ccaatgatac agatatggag cattgtgtga gatgtccaga ggattcgtac
     1681 gccaacttag aacaaaccga gtgcctccaa agagttgtga cttttctcgc ttatgaagat
     1741 ccattaggga tggctctagg atgcatggcc ctgtccttct cagccatcac aattctagta
     1801 ctagtcactt ttgtgaagta cagggatact cccattgtga aagccaataa ccgcattctc
     1861 agctacatcc tgctcatatc tctagccttc tgttttctgt gctcattgct cttcattgga
     1921 catcccaacc aggccacctg catcctgcag cagaccacat ttgcaatatt tttcacagtt
     1981 gctatttcta ctgtgttggc caaaacaata actgtggtca cagctttcaa gcttactaca
     2041 ccagggagaa ggataagaaa gatgatgata aaaggggcaa ttaacttgct cattcccatt
     2101 tgtaccctaa tccaacttgt tctctgtgca atctggttgg tgacatctcc tccatttatt
     2161 gacagagata tacaatctga acatgggaag ataatcatca tttgcaacaa aggctcagtc
     2221 attgccttcc acattgtctt gggatatttg ggctccttgg ctctggggag cttcactgtg
     2281 gctttcttgg ctaggaacct tcctgacaga ttcaatgagg ccaagttcct aacattcagc
     2341 atgttggtct tctacagtgt ttggatcacc ttcctccctg tataccacag caccaggggg
     2401 aaggttatgg ttgttgttga ggttttctcc atcttggctt ctagtgcagg gttgctaggg
     2461 tgtatatttg tccaaaagtg ttatgttctt ttagttcaac cagatttaaa tgttcttcag
     2521 aaataa
//
LOCUS       NM_001167548             951 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 13 (Vom1r13), mRNA.
ACCESSION   NM_001167548
VERSION     NM_001167548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 19952141
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-951               JAXUCZ010000001.1  68937347-68938297
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..951
                     /gene="Vom1r13"
                     /note="vomeronasal 1 receptor 13"
                     /db_xref="GeneID:100312667"
                     /db_xref="RGD:2316473"
     CDS             1..951
                     /gene="Vom1r13"
                     /note="non-AUG (CUG) translation initiation codon;
                     vomeronasal 1 receptor Vom1r13"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 13"
                     /protein_id="NP_001161020.1"
                     /db_xref="GeneID:100312667"
                     /db_xref="RGD:2316473"
                     /translation="MRNVWQHILKSVFLSNTMDARNLGVGITFLLQSVVGLLGNISLI
                     FYYLIIYYKKHKIKPMDLILMHLIIVNILIILSKGLATTMATFGLKLFFNDWSYQFFM
                     YVLRVFRSMSIVTICLLSVFQAITIMPRNSCLKNLRVKTTMDISFCISLCWVLYIIIN
                     VIFPLYMSITLSRKNITKDTNFKLYTIVGYDKITGSLYTTFFVFPEILFSGLITWSSS
                     SMIVLLYRHKRRVQYLQSTHASHSSSPESRATQNILVLVSIFLAFYTISAISHAYSAL
                     FHSSDGWLMIFSNILTLCLPTSSLFVLMSHSSSLSKLCFL"
     misc_feature    76..948
                     /gene="Vom1r13"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    76..948
                     /gene="Vom1r13"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    76..147
                     /gene="Vom1r13"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    76..147
                     /gene="Vom1r13"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    181..246
                     /gene="Vom1r13"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    181..246
                     /gene="Vom1r13"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    295..363
                     /gene="Vom1r13"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    295..363
                     /gene="Vom1r13"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    439..489
                     /gene="Vom1r13"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    439..489
                     /gene="Vom1r13"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    592..663
                     /gene="Vom1r13"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    592..663
                     /gene="Vom1r13"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    748..816
                     /gene="Vom1r13"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    748..816
                     /gene="Vom1r13"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    844..921
                     /gene="Vom1r13"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    844..921
                     /gene="Vom1r13"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..951
                     /gene="Vom1r13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagaaatg tttggcagca tattttgaag tcagtttttc tcagtaacac tatggatgcc
       61 aggaatttgg gagtaggaat aacatttctg ttacagagtg tagttggact tctaggaaac
      121 atctctctca ttttctacta cttgattatt tactataaga aacacaaaat aaagcccatg
      181 gatttgattc tcatgcacct gataatagtt aacatcttga tcattctctc taaaggattg
      241 gctaccacaa tggcaacttt tggcttgaaa cttttcttta atgattggag ctatcaattt
      301 tttatgtatg tcctaagagt tttcaggagc atgtccattg tcaccatctg cctcttaagt
      361 gtcttccagg ctatcaccat catgccaaga aactcctgtt tgaaaaatct tagagtcaag
      421 actacaatgg acattagttt ctgcatttct ctctgctggg tcttgtacat cattataaat
      481 gttattttcc ctttgtacat gtccataaca ttaagtagga aaaatataac aaaggataca
      541 aatttcaagc tctatactat tgtaggatat gacaaaatca caggttcatt atatacaaca
      601 ttctttgtgt ttcctgaaat tctgttttct ggtcttatca cttggtccag tagctcaatg
      661 attgtccttc tgtacaggca caaacgacga gttcaatacc tccaaagtac tcatgcttcc
      721 catagcagct cccctgaatc cagagccact cagaacattc tggtactagt ttccatcttt
      781 cttgcttttt atacaatctc tgccatctca catgcttaca gtgctctttt tcacagttca
      841 gatgggtggc tgatgatttt ctcaaacatt ttaactttgt gtcttcccac ttcaagcctt
      901 tttgtactta tgagtcactc atcctctctg tccaaactct gctttctcta g
//
LOCUS       NM_001346434             884 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CFAP97 domain containing 2 (Cfap97d2), transcript
            variant 1, mRNA.
ACCESSION   NM_001346434 XR_001834062 XR_001841686
VERSION     NM_001346434.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Oct 12, 2016 this sequence version replaced
            XR_001841686.1, XR_001834062.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1209443.1,
                                           SRR22582416.337887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000016.1  82528885-82529050   c
            167-247             JAXUCZ010000016.1  82512490-82512570   c
            248-366             JAXUCZ010000016.1  82511368-82511486   c
            367-536             JAXUCZ010000016.1  82508838-82509007   c
            537-884             JAXUCZ010000016.1  82504637-82504984   c
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..884
                     /gene="Cfap97d2"
                     /note="CFAP97 domain containing 2"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
     exon            1..166
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Cfap97d2"
                     /note="upstream in-frame stop codon"
     CDS             77..604
                     /gene="Cfap97d2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein CFAP97D2 isoform 1"
                     /protein_id="NP_001333363.1"
                     /db_xref="GeneID:688801"
                     /db_xref="RGD:1584165"
                     /translation="MHRVPQLTTPWASRDLQRAWEKTYQNHRKKVQNAQPLVDTRPPQ
                     TYSHLHLKFKKLKMEEERLSIIDRNNYLLLQRVASAMKTGRRIDGQNNFTWRSLNRKS
                     REQALMKVQKQNQAVPERLRSSEPWYGAQRWREDWTAMATRPCTCRHTWRKGADREAQ
                     QGHSLIWMRSLKRKG"
     misc_feature    158..442
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     misc_feature    158..442
                     /gene="Cfap97d2"
                     /note="Hemingway/CFA97; Region: Hmw_CFAP97; pfam13879"
                     /db_xref="CDD:464014"
     exon            167..247
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..366
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..536
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..884
                     /gene="Cfap97d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcaaaca gctctgcggg ggctgtactg ctgtgcctgc tcttccctga agggaccctg
       61 gagtttgtga tctgagatgc atagagtgcc ccagctgacc accccgtggg ctagtagaga
      121 cctgcagaga gcctgggaga aaacctacca gaaccacagg aaaaaggtcc agaacgccca
      181 accactcgtg gacacccgcc caccacagac ttacagccac ctccacctaa agttcaagaa
      241 gttgaagatg gaggaagaga gactctccat cattgacaga aacaactacc tgcttctgca
      301 gagggtggcc tccgccatga aaaccgggag acggattgat gggcaaaata acttcacatg
      361 gagaagtcta aacaggaaat cgagagaaca ggcattgatg aaagtgcaga aacaaaatca
      421 agccgttcca gaaagactca gaagctcaga gccctggtat ggagcacaga gatggcggga
      481 ggactggact gccatggcca cgcgtccctg cacatgcaga cacacctgga gaaaaggagc
      541 tgatcgtgaa gcccaacaag gccacagcct catctggatg cgcagcctga agcggaaggg
      601 gtgagggttc acgacccaac caccgaaaga agaccagggc ctggaagctc cgatgaggcc
      661 ttcctgtgtc tcccaggggt gggggtgggg atgtggggtg tgcaggtcta gcatccgaga
      721 tcacgctggc tctggggacg gctgtgggag ctgtgacgcg gcactctgaa gcttcacggt
      781 cacggccgtc gccagatgac acagcacggc tgtttactgt gtttcttgga ccgataacca
      841 aaaacaaaat atgcagagtg actctgcgag ttacaggatt tgaa
//
LOCUS       NM_001111321            2556 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 80 (Vom2r80), mRNA.
ACCESSION   NM_001111321 XM_001061151 XM_577747
VERSION     NM_001111321.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On or before Dec 14, 2007 this sequence version replaced
            XM_577747.2, XM_001061151.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  71494406-71494602
            198-483             JAXUCZ010000001.1  71496286-71496571
            484-1284            JAXUCZ010000001.1  71496871-71497671
            1285-1512           JAXUCZ010000001.1  71499230-71499457
            1513-1636           JAXUCZ010000001.1  71504731-71504854
            1637-2556           JAXUCZ010000001.1  71506967-71507886
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2556
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="vomeronasal 2 receptor, 80"
                     /db_xref="GeneID:502285"
                     /db_xref="RGD:1559687"
     CDS             1..2556
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 80 precursor"
                     /protein_id="NP_001104791.1"
                     /db_xref="GeneID:502285"
                     /db_xref="RGD:1559687"
                     /translation="MFTLILFFLLLNNPVHVAGFNYPTCSWRIKQNRGKGGNSETDCI
                     FLILPVKGPVEKDDFKPLLNTQTLTENHKHALVLAFSVNEINRNPDLLPNMSLTMDIP
                     SCNWTSKFRNTIYDSLHNYKILPNYSCQDNLLCVVALTGGNWATTLLLYTVLSYFIYQ
                     QFFLLTYRPFHPALHDHENFPYLYQMSSDDTSLALALVSFIIHFSWNWIGLAISDNEQ
                     STHFLSYLKRGMERNTVCFAFVSMIPVDMDLYMSRAEVYYNQIVTSSTNVVIIYGDTG
                     GTLAVSFRMWESLGLQKLWITTTRWDVTPSKKDNLYGLFAFGHHHGEIPGFKNFVQTL
                     NPVTSSDENLAKLEWMYFNCEVSASKCKALKNCSSNHSLEWLMAHTFEMTFTEGSYDI
                     YNAVYAAAHVFHEINLQIFHNPPIAKGKVQNYVCNKLGSSLRKIHFTNPVGDRINMNQ
                     RDKQQEIYDIFYIWNFPQGLEFKVKIGLFSPYFINGQQLHLSGDMIEWARGSTQMPTS
                     VCSSDCGPGFRKFRKKEMSACCFDCNPCPENEISNETNVEMCILCPEDQYANTGQNHC
                     IQKALIFLTYEDPLGRVLSLMALGFSAFTALVLGIFLKHHHTPIVKANNSTLTYILLI
                     SLIFCFLCPLLFIGLPDLATCILQQITFGVVFTVAISTVLAKTITVILAFKVTAPQRM
                     MKYFLVSRVPNYIIPICTLLELLVCAVWLGAFPPSVDIDDQSEHGHIIIICNKGSVTA
                     FYCVLGYLACLAFVSFTLAFLSRNLPSTFNESKSITFSMLVVCSVWVTFLPVYHSTKG
                     KVMVAVEIFSILASSSGMLLCIFVPKCYIILFRPDRNSFQMIREKSSSHTHIS"
     sig_peptide     1..57
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    118..1494
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1494
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,502..507,1162..1164)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,502..507,1162..1164)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(319..321,328..330,454..456,724..726)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(319..321,328..330,454..456,724..726)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1516..1677
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1516..1677
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1735..2490
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1735..2490
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1735..1812
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1735..1812
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1744..1746,1753..1758,1765..1770,1774..1779,
                     1879..1881,1891..1893,1900..1905,1927..1929,1939..1941)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1744..1746,1753..1758,1765..1770,1774..1779,
                     1879..1881,1891..1893,1900..1905,1927..1929,1939..1941)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1846..1911
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1846..1911
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1906..1908,1942..1947,1954..1959,1966..1968,
                     2206..2208,2221..2223,2230..2235,2242..2244,2344..2346,
                     2353..2358,2365..2367,2377..2379,2401..2406,2413..2415,
                     2422..2424,2434..2436)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1906..1908,1942..1947,1954..1959,1966..1968,
                     2206..2208,2221..2223,2230..2235,2242..2244,2344..2346,
                     2353..2358,2365..2367,2377..2379,2401..2406,2413..2415,
                     2422..2424,2434..2436)
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1936..2010
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1936..2010
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2080..2130
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2080..2130
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2209..2289
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2209..2289
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2311..2382
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2311..2382
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2395..2472
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2395..2472
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
     exon            198..483
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1284
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1512
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1636
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..2556
                     /gene="Vom2r80"
                     /gene_synonym="RGD1559687"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcactc tgattttatt cttcttgctc ttgaacaatc cagttcatgt ggctggtttt
       61 aattatccca cctgctcttg gagaataaag cagaatagag gcaagggtgg aaactcagaa
      121 actgactgta tcttcttgat tctaccagta aaagggcctg tggagaaaga cgatttcaag
      181 cctcttttga atacacaaac actcactgaa aaccacaagc atgctctagt cttggctttt
      241 tccgtaaatg aaatcaacag gaacccggat cttttgccaa atatgtctct aacaatggat
      301 ataccaagtt gtaactggac atccaaattt agaaatacca tttatgatag tttacataat
      361 tataaaattc tccctaatta ttcctgtcag gataacctcc tgtgtgtagt ggcacttaca
      421 ggaggaaact gggcaacaac tctgttactt tatacagtct taagctactt catatatcag
      481 cagttctttc ttctgactta tcgacctttc catcctgccc tgcatgatca tgaaaacttt
      541 ccctatctat atcagatgtc ctctgatgat acatctctag cccttgccct ggtgtctttt
      601 ataatacatt tcagttggaa ctggataggg ttggccatct cagacaatga acaaagtacc
      661 cattttctct catatttgaa aagagggatg gaaagaaata cagtctgctt tgcttttgtc
      721 agcatgattc cagtcgatat ggatttatac atgtcaagag ctgaagtgta ttacaaccaa
      781 attgtgacat catctacaaa tgttgttatc atttatggtg acacaggtgg tactttagct
      841 gtgagtttta gaatgtggga atctctaggt ttacagaaat tatggatcac caccacacgg
      901 tgggatgtca ctcctagtaa gaaagacaat ttatatgggt tatttgcttt tggacaccac
      961 catggtgaga ttcctggttt taaaaatttt gtccagacat tgaaccctgt cacatcctca
     1021 gatgaaaatc tggcaaagct ggagtggatg tactttaact gtgaagtctc agcatctaaa
     1081 tgtaaggcac tcaagaactg ttcatctaat cactcactgg aatggctaat ggcgcatact
     1141 tttgaaatga cctttactga aggaagttat gacatataca atgctgtgta tgctgctgcc
     1201 catgtatttc atgagattaa tttgcaaatc tttcataatc cgcccattgc caaagggaaa
     1261 gtacaaaatt atgtctgcaa taagctgggt tcctctttga gaaagatcca cttcactaat
     1321 cctgttggag acagaataaa tatgaatcaa agagacaaac agcaagaaat atatgacatt
     1381 ttctacattt ggaattttcc acagggactt gaatttaaag tgaaaatagg actatttagt
     1441 ccctatttta taaatggtca acagttacat ttatctggag atatgataga gtgggcaaga
     1501 ggaagtacac agatgccgac ctctgtgtgc agttctgatt gtggtccagg atttagaaaa
     1561 ttcaggaaga aggaaatgtc agcctgctgt tttgattgca atccctgccc agaaaatgaa
     1621 atttctaatg agacaaatgt ggagatgtgt atcctgtgcc cagaggacca atatgccaac
     1681 acagggcaga atcactgcat tcaaaaagct cttatctttc tcacttatga agacccccta
     1741 gggagggtac tttctttaat ggccttgggc ttctctgcat tcacagctct ggttcttggc
     1801 atctttctga agcaccacca tactcccatt gttaaggcca ataacagcac tcttacctac
     1861 atcttgctca tctccctcat tttttgtttc ctttgcccct tgctcttcat tggccttcca
     1921 gacttggcca catgcatcct gcagcaaatc acatttggag ttgtattcac agtggctatt
     1981 tccacagtgt tagccaaaac aattactgtc attctggcat tcaaagtcac agcccctcaa
     2041 agaatgatga aatattttct tgtttcacga gtacctaact acatcattcc catctgtact
     2101 ctccttgaac ttcttgtctg tgcagtctgg ttaggagctt ttcctccttc tgtggacatt
     2161 gatgatcaat cagagcatgg tcacatcatc attatttgca acaagggttc agtcactgct
     2221 ttttactgtg ttctgggata cctggcctgc ctggcctttg tgagctttac attggctttc
     2281 ctttccagaa acctgcctag caccttcaat gaatccaagt ctataacatt cagcatgctg
     2341 gtggtctgca gtgtctgggt cactttcctc cctgtttacc atagcaccaa aggcaaggtc
     2401 atggtggctg ttgagatctt ttccattttg gcttccagtt cagggatgct gctttgcatc
     2461 tttgttccca aatgttacat aatactgttt agaccagaca gaaattcctt tcaaatgatc
     2521 agggagaaat catcttccca tactcacatt tcctaa
//
LOCUS       NM_001167551             918 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 39 (Vom1r39), mRNA.
ACCESSION   NM_001167551
VERSION     NM_001167551.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-918               JAXUCZ010000001.1  77416987-77417904   c
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..918
                     /gene="Vom1r39"
                     /note="vomeronasal 1 receptor 39"
                     /db_xref="GeneID:100312670"
                     /db_xref="RGD:2316471"
     CDS             1..918
                     /gene="Vom1r39"
                     /note="vomeronasal 1 receptor Vom1r39"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 39"
                     /protein_id="NP_001161023.1"
                     /db_xref="GeneID:100312670"
                     /db_xref="RGD:2316471"
                     /translation="MPAPDKSLKTTEEVALQILLLCQFGVGTVANIFLFIHNFSPILT
                     GSQQRATHMILTNIAVANTLILFVTVFPINMMTFAQRSPLTDLKCKFEFFTRLVARST
                     NLCSTCVLSIQQFLTLVPVHRSKVLLRANVPNFATYSCCSCWVFSVLNNIYIPVMVTG
                     PQITDNKTDSKRKLFCSTSGFTVGIVFLRFIHDVTFISIMVWTSVSMVLLLHRHLQRM
                     QHILTPNQNTRGQAETRATHTILMLVVTFVSFYILNFICIIFHNFFMDSRLFVRHVSE
                     ALVLGFPTISPLLLIFRDPKNPCSVLFSS"
     misc_feature    40..876
                     /gene="Vom1r39"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    40..876
                     /gene="Vom1r39"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    46..120
                     /gene="Vom1r39"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    46..120
                     /gene="Vom1r39"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    154..219
                     /gene="Vom1r39"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320087"
     misc_feature    154..219
                     /gene="Vom1r39"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320087"
     misc_feature    268..336
                     /gene="Vom1r39"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    268..336
                     /gene="Vom1r39"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    412..462
                     /gene="Vom1r39"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    412..462
                     /gene="Vom1r39"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    562..624
                     /gene="Vom1r39"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     misc_feature    562..624
                     /gene="Vom1r39"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     misc_feature    709..783
                     /gene="Vom1r39"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320087"
     misc_feature    709..783
                     /gene="Vom1r39"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320087"
     misc_feature    802..876
                     /gene="Vom1r39"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320087"
     misc_feature    802..876
                     /gene="Vom1r39"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320087"
     exon            1..918
                     /gene="Vom1r39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcctgctc ctgataaatc cttgaaaaca actgaggaag tggctcttca gatccttttg
       61 ctttgtcagt ttggggttgg gactgtggcc aatatttttc tgtttatcca taatttctct
      121 ccaatcttaa ctggttctca acagagggcc acacatatga ttttaacaaa catagctgtg
      181 gccaatacct tgattctctt cgtcactgtc tttccaatca acatgatgac ttttgctcaa
      241 agaagtcctc taactgacct caaatgtaaa tttgaatttt tcactcgcct ggtggcaaga
      301 agcaccaact tgtgttccac ctgtgtcctg agtatccaac agtttctcac tcttgttcct
      361 gttcatagaa gtaaagtttt gcttagagca aatgtcccaa attttgctac ttactcttgt
      421 tgcagttgtt gggtcttcag tgtgttaaat aacatctaca ttccagttat ggtcactggt
      481 cctcagataa cagacaataa aactgattca aaaagaaagt tgttctgttc cacatctgga
      541 ttcactgtag gcattgtctt cttgaggttt atccatgatg tcacattcat tagcatcatg
      601 gtctggacca gtgtctccat ggtgcttctc ctccatagac atctccagcg aatgcagcac
      661 atcctgactc ccaatcagaa caccagaggt caagctgaga caagagcaac ccatactatc
      721 ctgatgttgg tggtcacatt tgttagcttt tatattctaa attttatttg tatcatcttt
      781 cacaactttt ttatggattc acgcctcttt gtgaggcatg tcagtgaagc tttggtctta
      841 ggattcccca caatttctcc cttattgttg atcttcagag atccaaagaa tccttgttct
      901 gtgttattca gctcttga
//
LOCUS       NM_001099514            2571 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 48 (Vom2r48), mRNA.
ACCESSION   NM_001099514 XM_001066682
VERSION     NM_001099514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 26, 2007 this sequence version replaced XM_001066682.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.908748.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN09345330,
                                           SAMN09345331 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000004.1  158347664-158347881
            219-516             JAXUCZ010000004.1  158348989-158349286
            517-1329            JAXUCZ010000004.1  158372514-158373326
            1330-1554           JAXUCZ010000004.1  158383015-158383239
            1555-1678           JAXUCZ010000004.1  158384497-158384620
            1679-2571           JAXUCZ010000004.1  158387752-158388644
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2571
                     /gene="Vom2r48"
                     /note="vomeronasal 2 receptor, 48"
                     /db_xref="GeneID:686145"
                     /db_xref="RGD:1585454"
     CDS             1..2571
                     /gene="Vom2r48"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 48"
                     /protein_id="NP_001092984.1"
                     /db_xref="GeneID:686145"
                     /db_xref="RGD:1585454"
                     /translation="MKLLIVFSLLIVLIVFQVQISYVSLNNPASPGYYQDGDFVIGGL
                     FSLRMTTGDTRSKLFDFKDAIYLPEYVYGYLTKHYQHMLAMIFAIEKINKDPNILFNM
                     SLGFYLFNVDFIEKKAIESSMALLSGESPPVPNYSCRPEKTDKLVAVIGGISTGISTQ
                     ISRVLSLYNIPQISYAPFDHSLGTRVQLQSPYQFPMHTTALYHGIIQLLLYFTWVWVG
                     MVVTDDMRGELFLRDITEEMNNHGLCVAFVEKIPEFSAQDRVTKKAFMERYTSTRVIV
                     GFGDTYSLLRFVSSIIFHTNFGNVWITTSYWDFTILPFYQFISRALFSVGRLSFSVRM
                     DQILGFKDFLRSVQPRKYPHDIFLQDVWSILFKCPYSYQHGVRILTQCEQNGTLSTRP
                     LHVWDMNTLPPSYKVHAAVYAIAQALHEELSLGMEGDSFTKCVPQTHLPWKLHPFLQK
                     GKLWRRTNQENIINKEVLATVFDIFNSQSLQKGNEVQVQVGEFVFESHSVQHFSLNEK
                     LITWPRNQKEIPLSLCSQSCPLGFRKTPVEGKPSCCFDCLPCPDGEIANETDMDQCIK
                     CPEDQYPNKQRNQCLPKITAFLSCEDPLGAVLVSVAISLSAFSAMILGLFIHYRDTPI
                     VRANNRNLSYLLLVSLMLCFFCSLIFICQPTTVTCILRQMIFGVVFSITISAILAKTF
                     IVVVAFKVIKPGSTLQTWMVTRVSNAIVCCGSSIQVCICAVWLGTYPPFPDVDMQSEF
                     GQIILWCNEGSTLAFYCVLGYLGFLASLSLLIAFLARRLPDTFNEAKTITFSMLVFCS
                     VWISFVPTYLSSKGKTMVAVEILSILASSSTLLGCIFLPKCYVILMRSGGHSRKKIFK
                     "
     misc_feature    118..1536
                     /gene="Vom2r48"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1536
                     /gene="Vom2r48"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(229..231,526..531,1207..1209)
                     /gene="Vom2r48"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(229..231,526..531,1207..1209)
                     /gene="Vom2r48"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(343..345,352..354,487..489,748..750)
                     /gene="Vom2r48"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(343..345,352..354,487..489,748..750)
                     /gene="Vom2r48"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1558..1719
                     /gene="Vom2r48"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1558..1719
                     /gene="Vom2r48"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1777..2532
                     /gene="Vom2r48"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1777..2532
                     /gene="Vom2r48"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1777..1854
                     /gene="Vom2r48"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1777..1854
                     /gene="Vom2r48"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1786..1788,1795..1800,1807..1812,1816..1821,
                     1921..1923,1933..1935,1942..1947,1969..1971,1981..1983)
                     /gene="Vom2r48"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1786..1788,1795..1800,1807..1812,1816..1821,
                     1921..1923,1933..1935,1942..1947,1969..1971,1981..1983)
                     /gene="Vom2r48"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1888..1953
                     /gene="Vom2r48"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1888..1953
                     /gene="Vom2r48"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1948..1950,1984..1989,1996..2001,2008..2010,
                     2248..2250,2263..2265,2272..2277,2284..2286,2386..2388,
                     2395..2400,2407..2409,2419..2421,2443..2448,2455..2457,
                     2464..2466,2476..2478)
                     /gene="Vom2r48"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1948..1950,1984..1989,1996..2001,2008..2010,
                     2248..2250,2263..2265,2272..2277,2284..2286,2386..2388,
                     2395..2400,2407..2409,2419..2421,2443..2448,2455..2457,
                     2464..2466,2476..2478)
                     /gene="Vom2r48"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1978..2052
                     /gene="Vom2r48"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1978..2052
                     /gene="Vom2r48"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2122..2172
                     /gene="Vom2r48"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2122..2172
                     /gene="Vom2r48"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2251..2331
                     /gene="Vom2r48"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2251..2331
                     /gene="Vom2r48"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2353..2424
                     /gene="Vom2r48"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2353..2424
                     /gene="Vom2r48"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2437..2514
                     /gene="Vom2r48"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2437..2514
                     /gene="Vom2r48"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..218
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
     exon            219..516
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1329
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1554
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1678
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2571
                     /gene="Vom2r48"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaattac tcatcgtttt ctctctcctg attgttctca ttgtattcca ggtacaaatt
       61 tcttatgtct ccttaaataa tcctgcttct cctggctact atcaagatgg ggattttgtt
      121 atcggaggac tcttttccct tagaatgact actggagaca ctagaagtaa attatttgac
      181 tttaaagatg caatctattt gccagaatat gtttatggat atctcactaa acattatcag
      241 cacatgttgg caatgatttt tgctatagaa aaaatcaaca aggacccaaa tattctattc
      301 aatatgtccc ttggattcta tctcttcaat gttgacttta ttgagaagaa ggccatagag
      361 agttctatgg ctttgctctc aggagagagc cccccagttc ctaactacag ctgcaggcct
      421 gagaagactg ataagctggt tgcagtgata gggggcattt caacaggaat atcaactcag
      481 atctcccgag ttctaagtct ctacaacatt ccacagatca gctatgctcc ttttgaccac
      541 agtcttggga ccagagtcca gctccagtct ccttaccagt ttccgatgca cactacagct
      601 ctatatcatg gaataattca actgctacta tacttcactt gggtctgggt tggcatggtg
      661 gttacagatg atatgagggg agaactcttc ctgagggaca tcacagagga gatgaacaac
      721 catggacttt gtgttgcatt tgtagaaaag attccagaat tttctgctca ggacagagta
      781 accaaaaaag cttttatgga aagatacaca tcaacacgtg ttattgttgg atttggtgac
      841 acatattctc ttctgaggtt tgttagtagt atcattttcc acactaattt tggtaatgtc
      901 tggatcacga cttcttattg ggatttcacc atacttcctt tttaccaatt tataagtaga
      961 gcattattct ctgttggaag attatcattt tctgttcgca tggatcaaat tctgggattc
     1021 aaggattttc tcagaagtgt tcaacctaga aaataccctc atgatatctt tctccaggat
     1081 gtgtggtcga tcttatttaa atgtccatat tcctatcagc atggagtcag gatactaact
     1141 caatgtgagc aaaatggcac cctgagcaca cgacctctgc atgtttggga catgaatacc
     1201 ttacccccaa gctacaaagt ccatgctgct gtatatgcca ttgcccaggc actccatgaa
     1261 gagctgtcac ttggaatgga aggagactcc ttcactaaat gtgtacccca gactcatctc
     1321 ccatggaagc tccatccatt tttacaaaag ggcaaactat ggagaaggac caatcaggag
     1381 aatattatta acaaggaggt tttggcaact gtatttgaca tcttcaattc ccagtctctg
     1441 caaaagggta atgaagttca agttcaagtt ggcgagtttg tctttgaatc tcacagtgtt
     1501 cagcattttt ccctaaatga aaaactcata acttggccca gaaaccaaaa ggagattcct
     1561 ttgtctcttt gcagtcaaag ttgtccactt ggatttagga aaacacctgt tgaagggaaa
     1621 ccctcctgtt gttttgattg tctcccatgt ccagatggag agattgcaaa tgaaacagat
     1681 atggatcaat gcatcaagtg ccctgaagat cagtatccaa ataagcagag gaatcagtgt
     1741 ctccctaaaa ttacagcatt tttgtcctgt gaagatcctc taggagcagt tttggtttct
     1801 gtggccatta gtttatctgc cttttcagcc atgattttag gattatttat ccactatcgg
     1861 gacacaccca ttgtcagagc aaataacaga aatctcagtt atctcctcct ggtttctcta
     1921 atgctctgct tcttttgctc attgatattc atttgtcaac ctacaacagt cacttgtatc
     1981 ttgagacaaa tgatttttgg ggttgtattt tctattacca tttctgctat cttagcaaag
     2041 accttcattg tggttgtggc cttcaaagtc atcaaaccag gaagcacctt acaaacatgg
     2101 atggtgaccc gagtctcaaa tgctatagtc tgctgtggtt ccagcattca agtgtgcatc
     2161 tgtgcagtct ggctgggaac gtatccccct ttccctgatg tcgacatgca gtcagagttt
     2221 gggcaaatca tcctctggtg taacgagggc tccacccttg ccttctattg tgttctgggc
     2281 tacttgggct ttctggccag tctcagcttg cttattgcct tcctggcaag aaggctgcca
     2341 gacacattca acgaggcaaa aacaatcaca ttcagcatgc tggttttctg cagtgtgtgg
     2401 atttcttttg tacccactta cctgagctcc aaaggcaaaa ccatggtggc tgtggaaatc
     2461 ctttcaattc tggcctctag ttctacacta ttgggctgca tatttcttcc caaatgctat
     2521 gttatcctaa tgaggtcagg tggccattct agaaagaaga tctttaaatg a
//
LOCUS       NM_001099479            2574 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 58 (Vom2r58), mRNA.
ACCESSION   NM_001099479 XM_001067069
VERSION     NM_001099479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Aug 15, 2007 this sequence version replaced XM_001067069.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000012.1  8194249-8194451
            204-495             JAXUCZ010000012.1  8230050-8230341
            496-1302            JAXUCZ010000012.1  8231132-8231938
            1303-1530           JAXUCZ010000012.1  8248294-8248521
            1531-1654           JAXUCZ010000012.1  8287332-8287455
            1655-2574           JAXUCZ010000012.1  8300243-8301162
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2574
                     /gene="Vom2r58"
                     /note="vomeronasal 2 receptor, 58"
                     /db_xref="GeneID:501793"
                     /db_xref="RGD:1583708"
     CDS             1..2574
                     /gene="Vom2r58"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 58 precursor"
                     /protein_id="NP_001092949.1"
                     /db_xref="GeneID:501793"
                     /db_xref="RGD:1583708"
                     /translation="MMLLLIFMFLLLQYSSDVYSFDRSYCASTTKTSVYKDGDMVVAA
                     FLPLFTITVDSASDNPSNNNFYIQFNLKNYQIVLAMVYATEEINRNPHILPNVSLGYD
                     IYNVLFNEWFTLDRCITWLSGPKKYVPNYTCRREMKSIAALTGISWIISTGIRTLLEL
                     YRYPQLTIGSFDPNLNNHEQFHDIYQIAYKDMSLTHGIVSLLNYFHWNWVGLIVSEGQ
                     NGFQIISEVRAEMDRNKICVEFVELIRVSEVSYLPSYLLNPTHLVKSTTNVIITYGDS
                     DFLRGFMLYSRQIFVTRKVWIMNSDWDIITQSQHFILNSLHGSLIFAHHHKETSGYRN
                     FIQTVHPSKYPEDFYLTRFWFFLFNCSFADDDCNTLENCLPNASLHETTGNHFDMVMT
                     EFAYNMYNAVYAVAQSLHKMLLHEVEVRQVRKAEDLTFSVWQLHPFLKNIHFTNPVGE
                     QVSLDETMKLNAEYDILNYWNFPEGLHLKVKVGQFSPYGPVGQQLSLSEDIIEWPTEI
                     TETPRSVCSESCGPGFRKSLIEGKRICCFDCIPCPENEISNETDVDQCMQCLDNQYAN
                     TAQNHCLQKSITFLDYEDPMGIGLSCIALCFSALTSLVLGIFLKQKNTPIVKANNRTL
                     TYVLLIALNFCFLCSFLFIGHPNTATCILQQTTFAVLFTVAVSTVLAKTITVVLAFKV
                     TAPGRRIRWLLVTRAPNFTVPICTLIQIVLCGVWLGNSPPFIDTDTRSEHEHIIIMCN
                     KGSVTAFYCVLGYLGALALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWVTFLPV
                     YHSTKGKHMVVVEVFSILVSSAGLLGCIFAPKCYIILLRPQRKSLQGHRDKIHYNYKT
                     Y"
     sig_peptide     1..60
                     /gene="Vom2r58"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    121..1512
                     /gene="Vom2r58"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1512
                     /gene="Vom2r58"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(214..216,505..510,1180..1182)
                     /gene="Vom2r58"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(214..216,505..510,1180..1182)
                     /gene="Vom2r58"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(328..330,337..339,466..468,727..729)
                     /gene="Vom2r58"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(328..330,337..339,466..468,727..729)
                     /gene="Vom2r58"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1695
                     /gene="Vom2r58"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1695
                     /gene="Vom2r58"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1753..2508
                     /gene="Vom2r58"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..2508
                     /gene="Vom2r58"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r58"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r58"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r58"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r58"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r58"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r58"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r58"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r58"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r58"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r58"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r58"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r58"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r58"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r58"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r58"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r58"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r58"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r58"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..203
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
     exon            204..495
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
     exon            496..1302
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1654
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2574
                     /gene="Vom2r58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgcttc ttctgatttt tatgttcctg cttctgcagt attccagtga tgtctactcc
       61 tttgaccgct cttactgtgc ttcaacgaca aaaactagtg tatacaagga tggagatatg
      121 gtagttgctg catttttacc tctttttact attactgtgg attctgcatc tgataatcca
      181 agcaataata atttctatat tcaatttaat ttaaaaaact accagattgt tctggcaatg
      241 gtttatgcca ctgaggagat caacagaaac ccccatattt tacccaatgt gtctctggga
      301 tatgatatat ataatgtcct cttcaatgaa tggtttacat tggatagatg catcacatgg
      361 ctttctgggc cgaagaagta tgtgccaaat tacacgtgta ggagagagat gaagtcaatt
      421 gcagccctaa caggcatatc ttggataata tctaccggta taaggacact gctagaactc
      481 tacagatatc cgcagctgac cattgggtct tttgacccta atctgaataa tcatgagcag
      541 tttcatgata tttatcaaat agcatacaag gacatgtctc tcacccatgg cattgtctcc
      601 ttgttgaatt atttccactg gaactgggta ggactgatcg tatctgaagg acaaaatggt
      661 tttcagataa tctcagaagt tagggcagaa atggatagaa acaaaatatg tgtagaattt
      721 gtggaattga tccgagttag tgaagtatct tatttaccaa gctacctatt gaatcctaca
      781 catcttgtga aatcaacaac aaatgtgatc atcacctatg gtgacagtga ttttctgaga
      841 ggctttatgc tttattcaag acaaattttt gttacaagga aagtctggat catgaactca
      901 gactgggata ttatcaccca gtcacagcat ttcattttaa attcattaca tggaagcctc
      961 atctttgcac atcaccacaa agaaacctct ggttacagaa attttatcca aacagttcat
     1021 ccttccaaat acccagaaga tttttacctt acaaggtttt ggttcttcct ttttaactgc
     1081 tcatttgctg atgatgactg caatacactg gagaactgtc tacctaatgc ttccttgcat
     1141 gaaacaacag ggaaccattt tgacatggtc atgactgagt ttgcttataa tatgtacaat
     1201 gcggtgtatg ctgtggccca aagccttcac aagatgcttc ttcatgaagt agaagtaaga
     1261 caagtaagaa aggcagaaga cctgacgttt tcagtctggc agctgcaccc ttttctgaag
     1321 aatattcatt ttactaatcc cgttggagaa caagttagtt tggatgagac aatgaaattg
     1381 aatgcagagt atgatattct caactactgg aactttcctg aaggtcttca tcttaaggtg
     1441 aaagttggac aattttcccc ttatggtcca gtaggtcaac aattatcttt atctgaggac
     1501 ataatagaat ggcccaccga aattacagag actcccaggt ctgtatgcag tgaaagttgt
     1561 ggtcctggat ttagaaaatc cctcatagaa ggaaaaagga tctgttgttt tgactgcatt
     1621 ccatgcccag agaatgaaat ttccaatgag acagatgtgg atcagtgtat gcagtgtcta
     1681 gacaatcaat atgccaacac agcacaaaac cactgcctcc aaaagtctat caccttcctg
     1741 gattatgaag accccatggg gataggtctg tcctgcatag ccttgtgctt ctctgcacta
     1801 acatctctag ttcttggcat ctttctgaag cagaagaaca ctcccattgt gaaggcaaat
     1861 aaccgcactc tcacctacgt cctgctcatt gcccttaact tctgttttct ctgctctttt
     1921 ctcttcattg gccatcccaa cacagccact tgcattctgc aacagaccac atttgcagtg
     1981 ctgttcactg tggctgtttc cacagtcttg gccaaaacaa ttaccgtggt cctggccttc
     2041 aaggtcactg ctccaggaag aagaatcagg tggttgttgg taacacgggc acctaacttc
     2101 acagtaccca tctgtacctt gatccaaatt gtcctgtgtg gagtctggct gggaaactcc
     2161 cctccgttca ttgacacaga tacacgctct gaacatgaac atatcatcat catgtgcaac
     2221 aagggctcag tcactgcctt ctactgtgtg ctgggttacc tgggggctct agctctggga
     2281 agcttcacct tggctttctt ggccaggaac ctacctgaca ccttcaatga agccaagttc
     2341 ctgacattca gcatgctggt gttctgcagt gtctgggtca ccttcctccc tgtctaccac
     2401 agtactaagg ggaagcacat ggtagttgtg gaagtcttct ccatcttggt ctccagtgca
     2461 ggacttctag gctgcatctt tgcccccaag tgctacatta ttttgttaag accacaaagg
     2521 aagtctcttc agggtcacag ggacaaaata cattataatt ataagactta ttaa
//
LOCUS       NM_175584               1038 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus trace amine-associated receptor 6 (Taar6), mRNA.
ACCESSION   NM_175584
VERSION     NM_175584.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF380191.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1038
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="trace amine-associated receptor 6"
                     /db_xref="GeneID:294124"
                     /db_xref="RGD:631384"
     CDS             1..1038
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="trace amine receptor 6; taR-4; taR-6; trace amine
                     receptor 4"
                     /codon_start=1
                     /product="trace amine-associated receptor 6"
                     /protein_id="NP_783174.1"
                     /db_xref="GeneID:294124"
                     /db_xref="RGD:631384"
                     /translation="MGSNSSPPAVLQLCYENVNGSCVKTPYSPGPRVLLYAVFGFGAV
                     LAVFGNLLVMISILHFKQLHSPTNFLIASLACADFWVGVSVMPFSMVRSIESCWYFGR
                     SFCTFHTCCDVAFCYSSLFHLSFISIDRYIAVTDPLVYPTKFTVSVSGICISISWILP
                     LAYSGAVFYTGVYADGLEEVSDAVNCVGGCQVVVNQNWVLIDFLSFLIPTLVMIILYG
                     NIFLVARQQAKKIETVGNKAESSSESYKARVARRERKAAKTLGITVVAFMISWLPYSI
                     DSLVDAFMGFITPAYIYEICVWCAYYNSAMNPLIYALFYPWFKKAIKVIMSGQVFKNS
                     SATMNLFSEQI"
     misc_feature    55..57
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q923Y5.1); glycosylation site"
     misc_feature    97..966
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="trace amine-associated receptors 6, 8, and 9,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_TAAR6_8_9;
                     cd15316"
                     /db_xref="CDD:320439"
     misc_feature    97..966
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="trace amine-associated receptors 6, 8, and 9,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_TAAR6_8_9;
                     cd15316"
                     /db_xref="CDD:320439"
     misc_feature    97..159
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    100..180
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    100..180
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320439"
     misc_feature    199..279
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    199..279
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320439"
     misc_feature    205..267
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    313..405
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    313..405
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320439"
     misc_feature    order(322..324,334..339,346..351,574..576,592..594,
                     601..606,613..615,811..813,820..825,832..834,877..879,
                     889..891,901..903)
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320439"
     misc_feature    order(322..324,334..339,346..351,574..576,592..594,
                     601..606,613..615,811..813,820..825,832..834,877..879,
                     889..891,901..903)
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320439"
     misc_feature    322..384
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    439..510
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    439..510
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320439"
     misc_feature    442..504
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    580..669
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    580..669
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320439"
     misc_feature    607..669
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    751..843
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    751..843
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320439"
     misc_feature    778..828
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    847..906
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Y5.1);
                     transmembrane region"
     misc_feature    868..945
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     misc_feature    868..945
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320439"
     exon            1..1038
                     /gene="Taar6"
                     /gene_synonym="Ta4; TRAR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggtagta actcgtctcc tcccgcagtc ctgcagctct gctatgagaa cgtgaatggg
       61 tcttgtgtga aaacccccta ctctcctggg ccccgcgtcc tcctgtatgc agtctttggc
      121 tttggggctg tgctggcagt gtttggaaac ctcttggtga tgatatccat cctccatttc
      181 aaacagctac actctcccac caacttcctc attgcgtcct tggcctgtgc tgacttctgg
      241 gtgggcgtct ccgtgatgcc gttcagcatg gtcaggtcca tcgagagctg ctggtacttt
      301 ggaagaagct tctgcacttt ccacacctgc tgtgacgtgg ctttttgcta ttcttctctc
      361 ttccacctga gcttcatctc cattgacaga tacatcgctg tcacggaccc tctggtctat
      421 cccaccaagt tcacggtgtc tgtgtcagga atttgcatca gcatctcctg gattcttccg
      481 ctggcgtaca gcggggctgt gttctacaca ggggtttatg ctgatggcct ggaggaagta
      541 tccgatgccg tcaactgcgt aggggggtgt caggtagttg tgaatcagaa ctgggtgctg
      601 atagattttc tttccttctt aataccgact cttgttatga taattctgta cggtaatatt
      661 tttctggtag ctagacaaca ggctaaaaag atagaaactg ttggtaacaa ggcagaatca
      721 tcctctgaga gttacaaagc cagagtggcg agaagagaga gaaaagcagc caaaaccctg
      781 ggaatcactg tggtagcatt catgatctca tggttaccct acagcattga ttcattagtc
      841 gatgctttta tgggcttcat cacccctgct tacatttatg aaatttgtgt ttggtgtgct
      901 tattacaact cagccatgaa ccctttgatc tacgctctat tttatccatg gtttaagaaa
      961 gcgattaagg ttattatgag tggccaggtg ttcaagaaca gctcagccac tatgaacttg
     1021 ttctctgagc aaatataa
//
LOCUS       NM_001191077            1095 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus progestin and adipoQ receptor family member 6
            (Paqr6), mRNA.
ACCESSION   NM_001191077 XM_001059976
VERSION     NM_001191077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1095)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001059976.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.34527.1,
                                           SRR26643284.3074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000002.1  176132337-176132374
            39-114              JAXUCZ010000002.1  176132771-176132846
            115-242             JAXUCZ010000002.1  176133451-176133578
            243-445             JAXUCZ010000002.1  176133660-176133862
            446-572             JAXUCZ010000002.1  176133938-176134064
            573-669             JAXUCZ010000002.1  176134690-176134786
            670-820             JAXUCZ010000002.1  176135006-176135156
            821-1095            JAXUCZ010000002.1  176135461-176135735
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1095
                     /gene="Paqr6"
                     /note="progestin and adipoQ receptor family member 6"
                     /db_xref="GeneID:681021"
                     /db_xref="RGD:1584722"
     exon            1..38
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            39..114
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1095
                     /gene="Paqr6"
                     /note="progestin and adipoQ receptor family member VI"
                     /codon_start=1
                     /product="membrane progestin receptor delta"
                     /protein_id="NP_001178006.1"
                     /db_xref="GeneID:681021"
                     /db_xref="RGD:1584722"
                     /translation="MLSLKLPQLLRVHQVPRVFWEEGIMSGYRCPTSSALDCVLSSFQ
                     MTNETVNIWTHFLPTWYFLWRLLALGSPGFHAEPYHLPLLVFLLPTCLYPFASCCAHT
                     FSSMSPRARHICYFLDYGALSLYSLGCAFPYAAYSMPASWLHSRLHQLFVPAAALNSF
                     LCTGLSCYSRFPELENPGLSKVLRTAAFAYPFLFDNLPLFYRLRLCWGRAHSCGRDAL
                     SCSHGYHLLCALLTGFLFAARLPERLAPGRFDYIGHSHQLFHICAVLGTHFQLEAVLA
                     DMGSRRGWLAMQEPILGLEATVATLSLAVIGNLLIIAAFTASLLRSPGACPLLQGGPL
                     EEELEAKQQ"
     misc_feature    190..876
                     /gene="Paqr6"
                     /note="Haemolysin-III related; Region: HlyIII; pfam03006"
                     /db_xref="CDD:427098"
     misc_feature    190..876
                     /gene="Paqr6"
                     /note="Haemolysin-III related; Region: HlyIII; pfam03006"
                     /db_xref="CDD:427098"
     exon            115..242
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            243..445
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            446..572
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            573..669
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            670..820
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1095
                     /gene="Paqr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcgga gccgaggcca cccggacgcg gcaaacaggt caacgtggag gtaccgggcc
       61 accatgctca gtctcaagct gcctcaactc cttcgagtcc atcaggtccc ccgggtgttt
      121 tgggaagaag gcatcatgtc tggctaccga tgccccacaa gctctgcctt agactgtgtc
      181 ctcagctcct tccagatgac taacgagacg gtcaacatct ggactcactt cctgcccact
      241 tggtacttcc tgtggcgcct cctggcgttg ggcagcccgg gcttccacgc ggagccgtac
      301 cacctaccgc tgctggtctt cctactgccc acctgcctct atccctttgc atcctgctgc
      361 gcgcacacct ttagctccat gtcgcctcgc gctcgtcaca tctgctactt cctggactac
      421 ggggcactca gcctctacag cctgggctgc gccttcccct atgctgccta ctccatgccg
      481 gcctcctggc tgcacagccg cctacaccag ctcttcgtgc ccgctgctgc actcaactcc
      541 ttcctgtgca ccggcctctc ctgctactct cggttcccag agctagaaaa ccccgggctc
      601 agcaaggttc tccgcacagc cgcctttgcc taccccttcc tgtttgacaa cctcccgctg
      661 ttctacaggc tgcggctgtg ttggggcagg gcccacagct gtgggcggga cgcactgagc
      721 tgcagccatg gttaccacct cctctgcgct ctgctcacag gcttcctttt tgcagcccgt
      781 ctaccagagc gcctggcgcc tgggcgcttc gactatattg gccacagcca ccagctgttc
      841 cacatctgtg cagtgctggg cacccacttc cagctggaag ccgtgctggc tgatatgggg
      901 tcccgcagag gctggctggc catgcaggaa cccatcctgg gcctggaggc caccgtggcc
      961 accttaagcc tggcagtgat tgggaacctg ctcatcatcg ccgctttcac agcctccttg
     1021 ctgcggagcc ctggggcctg ccccctgctg cagggtggcc ccctcgaaga ggaactcgaa
     1081 gccaaacaac agtga
//
LOCUS       NM_001195558            1155 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 58 (Lrrc58), mRNA.
ACCESSION   NM_001195558 XM_001069929 XM_221433
VERSION     NM_001195558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Nov 24, 2010 this sequence version replaced
            XM_221433.5, XM_001069929.2.
            
            Sequence Note: This RefSeq record was created from Celera genomic
            sequence data as a full-length  transcript is not represented in
            the current reference genome assembly. The genomic coordinates used
            for the transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.39357.1,
                                           SRR26643299.48131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               JAXUCZ010000011.1  76367771-76368309   c
            540-668             JAXUCZ010000011.1  76360312-76360440   c
            669-946             JAXUCZ010000011.1  76358959-76359236   c
            947-1155            JAXUCZ010000011.1  76355987-76356195   c
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1155
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine rich repeat containing 58"
                     /db_xref="GeneID:303919"
                     /db_xref="RGD:1307440"
     exon            1..539
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1155
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 58"
                     /protein_id="NP_001182487.1"
                     /db_xref="GeneID:303919"
                     /db_xref="RGD:1307440"
                     /translation="MEEAALGEAELNWSRLSVSAEALESELEARAEERRGSREALLRL
                     LLPYNRLTSLPRALGSGFPHLQLLDVSGNALTALGPELLTLSGLRTLLARNNRLGGPG
                     SLPKGLGQSPLCRSLQVLNLSGNCFQELPASLLELRALQTLSLGGNQLQSIPAEIENL
                     QSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNL
                     LTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRSISYTPYD
                     LPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPC
                     SSASHSSTSQSESDSEDEASVAAHRMQKVLLG"
     misc_feature    64..>780
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    64..>780
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    175..246
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    175..246
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    247..315
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    247..315
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    316..402
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    316..402
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    403..471
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    403..471
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    472..540
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    472..540
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    541..609
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    541..609
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    610..678
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    610..678
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    679..747
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    679..747
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            540..668
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /inference="alignment:Splign:2.1.0"
     exon            669..946
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1155
                     /gene="Lrrc58"
                     /gene_synonym="RGD1307440"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcttcagg ttccggggcg cgccgcctcg gctagcggcc tggggtccgg cgggatggag
       61 gaggccgcgc tcggggaggc cgaactcaac tggtcccgcc tcagcgtgtc ggccgaggcg
      121 ctggagtcgg agctggaggc gcgcgcggag gagcggcgcg gctcacggga ggcgctgctg
      181 cggctgctgc tgccgtataa ccgtctgacg tcgctgccac gggcgctggg cagcggcttc
      241 ccacacctcc agctcctgga cgtgagcggc aacgcgctca cggcgctggg acccgagctg
      301 ctgacgctga gcggcctgcg cacgctgctg gccaggaaca accggctcgg cggcccgggc
      361 tcgctgccca agggcctggg ccagtcgccg ctctgccgca gcctccaggt actcaacctc
      421 agcggcaact gcttccagga gctgccggcc tcgctgctgg agctgcgcgc gcttcagacc
      481 ctcagcctgg gaggcaacca gctgcagagc atccccgccg agatcgagaa cttgcagagt
      541 ttagaatgtt tataccttgg aggaaacttc attaaagaaa tcccaccaga attagcaaat
      601 ctgccttctc tgaattactt ggtgttgtgt gacaacaaga tccaaagtgt gcctcctcag
      661 ctctcacagc tgcattcgct tcgatccctc agtctacaca ataacttgct gacgtacctg
      721 cctcgagaga tcctcaatct tattcacctg gaagagttga gtttacgagg aaacccattg
      781 gtggtccgtt ttgttagaga tttaacgtat gaccctccaa ctcttctgga attagctgca
      841 aggaccatta agatccgaag tatttcttac actccctatg atcttcctgg gaatcttctt
      901 agatacttgg gctctgccag caattgtcca aacccaaagt gcggtggagt ctattttgac
      961 tgttgtgtca gacagattaa gtttgtggac ttctgtggga agtaccgcct ccccctcatg
     1021 cactatctgt gttctccaga gtgctcctcc ccctgcagct ctgcctcaca cagctccaca
     1081 tcccagagtg agtctgactc agaagatgag gccagtgtgg ccgcacacag aatgcagaaa
     1141 gttcttcttg gttga
//
LOCUS       NM_001099490            2574 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 15 (Vom2r15), mRNA.
ACCESSION   NM_001099490 XM_001075192
VERSION     NM_001099490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 26, 2007 this sequence version replaced XM_001075192.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  71765852-71766048   c
            198-489             JAXUCZ010000001.1  71763639-71763930   c
            490-1302            JAXUCZ010000001.1  71762434-71763246   c
            1303-1530           JAXUCZ010000001.1  71760813-71761040   c
            1531-1654           JAXUCZ010000001.1  71752954-71753077   c
            1655-2574           JAXUCZ010000001.1  71750228-71751147   c
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2574
                     /gene="Vom2r15"
                     /note="vomeronasal 2 receptor, 15"
                     /db_xref="GeneID:690680"
                     /db_xref="RGD:1593392"
     CDS             1..2574
                     /gene="Vom2r15"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 15"
                     /protein_id="NP_001092960.1"
                     /db_xref="GeneID:690680"
                     /db_xref="RGD:1593392"
                     /translation="MFTLSLFFLLLNIPLLMTCLIYPRCFWSMRQDEYENRSLERGCA
                     FFIRAVKWPVEKEYFSNALNIQTHTENQKYALALAFSMNEINLNPNLLPNMSLVFTYS
                     TDACDWEAIFKSVIHLDLQEHKILPNYICTEDIKCGVALTGFNWATTVTIHILLNNFI
                     FQKFIHLTYGSFYPVLSDHEKFPYLYQMASEDTSLALALVSFIIHFSWNWVGLAISDN
                     DKGTQFLSYLRREMEKNTVCFAFVNMIPVNMRLFMSRAEVYYNQIMTSSTNVVIMYGD
                     KDSTLAVSFRMWVSLGIQRIWITTAQWDVTPRMKDLTFDNLCGTFAFGQHHGEIYGLK
                     NYAQTLNPFIYSDEYLLKLEWMYFNCNVTASKWKPFKNCSSNHSLEWLMTHTFDMAFI
                     EGSYDIYNAVYAFAHALHQVTFQKGDNLPTDNRKEQDYDCKKLCSFLRKTHFTNPAGD
                     RVNMNQIEKLQEEYDIFYIWNFPQGIGLKLKIGIFSPYFQTGQHLHLSEDIIEWAKEG
                     SQMLTSVCSADCGPGFRKFRKNGMPACCFDCSPCPENKISNETNVEMCILCPEDQYAN
                     TEQNHCIQKPLIFLTYEEPLGITISLMALCFSALTAVILGVFVKHHSTPIVKASNHIL
                     TYILLISLIFCFLCPLLFIGHPNSATCILQQITFGVVFTVAISTVLAKTITVILAFKV
                     TAPQRMMKYFLVQRASNYIIPMCTLIQVIVCAVWLGASPPFVDIDTQSEHGHIIIVCN
                     KGSVTAFYCVLGYLACLSFASFFLAFFSRNLPGNFNEAKSMTFSMLLFCSVWITFLPV
                     YHGTKGKVMVAVEIFSTLASSAGMLGCIFIPKCYTILFRPDKNSLQMIREKLSSHTHI
                     S"
     misc_feature    124..1512
                     /gene="Vom2r15"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    124..1512
                     /gene="Vom2r15"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r15"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r15"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,331..333,460..462,730..732)
                     /gene="Vom2r15"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,331..333,460..462,730..732)
                     /gene="Vom2r15"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1537..1695
                     /gene="Vom2r15"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1537..1695
                     /gene="Vom2r15"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1753..2508
                     /gene="Vom2r15"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..2508
                     /gene="Vom2r15"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r15"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r15"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r15"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r15"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r15"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r15"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r15"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r15"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r15"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r15"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r15"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r15"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r15"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r15"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r15"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r15"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r15"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r15"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
     exon            198..489
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1302
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1654
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2574
                     /gene="Vom2r15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcacct tgagtttatt cttcttgctc ctgaacattc cacttcttat gacttgtctc
       61 atttatccca gatgcttttg gagtatgagg caggatgaat atgagaatag aagcctggaa
      121 agaggttgtg ccttctttat tcgtgctgta aaatggcctg tggaaaaaga gtatttcagt
      181 aatgctttga atatacaaac acatactgaa aaccaaaagt atgctctggc cttggctttt
      241 tccatgaatg aaatcaacct gaatcctaat cttttaccaa atatgtctct agtatttaca
      301 tattcaacag atgcttgtga ttgggaagcc atattcaaaa gtgttattca tttggattta
      361 caagaacata aaattctccc taattatatc tgtaccgaag acatcaagtg tggagtggca
      421 cttacaggat ttaattgggc aacaactgtg acaattcata tactcctaaa caatttcata
      481 tttcagaagt tcattcatct tacttatgga tccttttatc ctgtcctgag tgatcatgaa
      541 aaatttccat atctatatca gatggcctct gaggatacat cactagccct tgctctggtc
      601 tccttcataa ttcatttcag ttggaattgg gtaggtttag ccatctcgga caatgataaa
      661 ggtacccaat ttctctccta tttgagaaga gagatggaaa aaaatacagt ctgctttgct
      721 tttgtcaaca tgattccagt caacatgcgt ttattcatgt caagagctga agtgtattac
      781 aaccaaatca tgacatcttc cacaaatgtt gttatcatgt atggtgacaa agacagtact
      841 ttagcagtga gctttagaat gtgggtatct ctaggtatac agagaatatg gatcaccact
      901 gcacagtggg atgtcactcc tagaatgaaa gatttaacat ttgataactt atgtgggact
      961 tttgcttttg gacaacacca tggtgaaatt tatggtttaa aaaattatgc ccagacattg
     1021 aaccctttca tatactcaga tgaatatttg ttaaagctgg aatggatgta ttttaactgt
     1081 aatgtcacag catctaaatg gaagccattc aagaactgct catctaatca ctcactggaa
     1141 tggctaatga cacatacttt tgacatggcc tttattgaag ggagttatga catatacaat
     1201 gctgtgtatg cttttgccca tgcactccat caagtgactt ttcaaaaggg tgataatctt
     1261 cccactgaca ataggaaaga acaagattat gactgcaaaa agctgtgttc ctttctgaga
     1321 aagacccact tcactaatcc tgctggggac agagtgaata tgaaccaaat agaaaaactg
     1381 caggaagagt atgacatttt ctacatttgg aattttccac agggcattgg tcttaaactg
     1441 aaaataggaa tattcagtcc atattttcaa actggtcaac atctacattt gtctgaagat
     1501 ataatagagt gggcaaaaga aggttcacag atgctgacct ctgtgtgcag tgctgattgt
     1561 ggtcctggat ttagaaaatt caggaagaat ggaatgccag cttgctgttt tgattgtagt
     1621 ccctgcccag aaaacaaaat ctctaatgag acaaatgtgg agatgtgtat cttgtgccca
     1681 gaggaccaat atgctaacac agagcagaat cactgcattc aaaaacctct tatctttctt
     1741 acttatgaag aacccttggg gatcacaatt tctttaatgg ccttgtgctt ctccgcactc
     1801 acagctgtga ttcttggggt cttcgtgaaa caccacagta ctcccattgt taaggctagt
     1861 aatcacattc tcacctatat cttgctgatc tcactcatct tttgtttcct ttgcccgttg
     1921 ctcttcatcg gccatccaaa ctcggccaca tgcatcctac agcaaatcac atttggagtt
     1981 gtattcacag tggctatttc cacagtgtta gccaaaacaa ttactgtcat tctggcattc
     2041 aaagtcacag cccctcaaag aatgatgaag tactttcttg ttcaaagggc atctaactac
     2101 atcattccca tgtgtactct catccaagtt attgtatgtg cagtctggct aggagcttct
     2161 cctccttttg ttgatattga tacacaatct gaacatggtc acatcatcat tgtttgcaac
     2221 aagggttcag tcactgcctt ttactgtgtc ctgggatacc tggcctgctt gtcctttgca
     2281 agtttctttc tggctttctt ttccagaaac ctgcctggta acttcaatga agccaagtcc
     2341 atgacattca gcatgctgtt gttctgcagt gtatggatca ctttccttcc tgtttaccat
     2401 ggcaccaaag gcaaagtcat ggtggctgtg gagatctttt ccacattggc ttccagtgca
     2461 gggatgcttg gttgcatctt cattcccaaa tgttatacaa tactgtttag accagacaaa
     2521 aattctcttc aaatgatcag ggagaaattg tcttcccata ctcacatttc atga
//
LOCUS       NM_001099466            2571 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 59 (Vom2r59), mRNA.
ACCESSION   NM_001099466 XM_221799
VERSION     NM_001099466.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Aug 19, 2007 this sequence version replaced XM_221799.4.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000012.1  7874913-7875115     c
            204-495             JAXUCZ010000012.1  7850752-7851043     c
            496-1302            JAXUCZ010000012.1  7849055-7849861     c
            1303-1530           JAXUCZ010000012.1  7840607-7840834     c
            1531-1654           JAXUCZ010000012.1  7824260-7824383     c
            1655-2571           JAXUCZ010000012.1  7811768-7812684     c
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2571
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="vomeronasal 2 receptor, 59"
                     /db_xref="GeneID:288396"
                     /db_xref="RGD:1566381"
     CDS             1..2571
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 59 precursor"
                     /protein_id="NP_001092936.1"
                     /db_xref="GeneID:288396"
                     /db_xref="RGD:1566381"
                     /translation="MMLLLIFMFLLLQYSNDVYSFDRSYCASRTKTSVYKDGDMVVAA
                     FLPLFTITVDSASDNQSNNNFHIQFNLKNYQIVLAMVYAIEEINRNPHILPNVSLGYD
                     IYNVLFNEWFTLHRCISWLSGPKKYVPNYTCRREMKSIAALTGISWIISTDIRTLLEL
                     YRYPQLTIGSFDPNLNNHEQFHDIYQIAYKDMSLTHGIVSLLNYFHWNWVGLIVSEGQ
                     NGFQIISEVRAEMDRNKICLDFVELIRVSEVSYLPSYLLNPTHLAKLTANVIITYGDS
                     DFLRGFMFYSRQIFVTRKVWIMNSDWDIITQSQHFILHSLHGSLIFAHHHKETSGYRN
                     FIQTVHPSKYPEDFYLTRFWFYFFNCSFADDDCSTLENCLPNASLHETPGNRFDMVMT
                     EFAYNMYNAVYAVAHSLHKMLLHEVEVREVRKAEDLIFSAWQLHPFLKNMQFTNPAGE
                     QVTLDEKMKLNAEYDILNYWNFPEGLHLKVKVGQFSPYGPLDQQLSLSEDIIEWPTEI
                     TETPRSVCSESCGPGFRKSLPEGKRICCFDCIPCPENEISNETDVDQCMQCLDHQYAN
                     TAQNHCLQKSMTFLHYEDPMGISLSCIALCFSALTSLVLGIFLKQKNTPIVKANNRTL
                     TYILLIALNFCFLCSFLFIGHPNTVTCILQQTTFAVVFTVAVSTVLAKTITVVLAFKV
                     TAPGRRIRWLLVTRAPNFIVPICTLIQIILCGVWLGNSPPFIDTDTHSENEHIIIMCN
                     KGSVTAFYCVLGYLGALALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWVTFLPV
                     YHSTKGKHMVVVEVFSILVSSAGLLGCIFAPKCYIILLRPQRNSLQSHRHKIHYKYMT
                     "
     sig_peptide     1..60
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    121..1512
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1512
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(214..216,505..510,1180..1182)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(214..216,505..510,1180..1182)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(328..330,337..339,466..468,727..729)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(328..330,337..339,466..468,727..729)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1695
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1695
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1753..2508
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..2508
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..203
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
     exon            204..495
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
     exon            496..1302
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1654
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2571
                     /gene="Vom2r59"
                     /gene_synonym="RGD1566381"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgcttc ttctgatttt tatgttcctg cttctgcaat attccaatga tgtctactcc
       61 tttgaccgct cttactgtgc ttcaaggacc aaaactagtg tatacaagga tggggacatg
      121 gtagttgctg catttttacc tctttttact attactgtgg attctgcatc tgataatcaa
      181 agcaataata atttccatat tcagtttaat ttaaaaaact accagattgt tctggcaatg
      241 gtttatgcca ttgaggagat caacagaaac ccccatattt tacccaatgt gtctctggga
      301 tatgatatat ataatgtcct gttcaatgaa tggtttacat tgcatagatg catctcatgg
      361 ctttctgggc caaagaagta tgtgccgaat tacacgtgta ggagagaaat gaagtcaatt
      421 gcagccctaa caggcatatc ttggataata tctaccgata taaggacact gctagaactc
      481 tacagatatc cgcagctgac cattgggtct tttgacccta acctgaataa tcatgagcag
      541 tttcatgata tttatcaaat agcctacaag gacatgtctc tcacccatgg cattgtctcc
      601 ttgttgaatt atttccactg gaactgggta ggactgatcg tatctgaagg acaaaatggt
      661 tttcagataa tctcagaagt tagggcagaa atggacagaa acaaaatatg tttagatttt
      721 gtggaattga tccgagttag tgaagtatct tatttaccaa gctacctatt gaatcctaca
      781 catcttgcaa aattaacagc aaatgtgatc atcacctatg gtgacagtga ttttctgaga
      841 ggctttatgt tttattcaag acaaattttt gttacaagga aagtctggat catgaactca
      901 gactgggata ttatcaccca gtcacagcat ttcattttac attcattaca tgggagcctc
      961 atctttgcac atcaccacaa agaaacctct ggttacagaa attttatcca aacagttcat
     1021 ccttccaaat acccagaaga tttttacctc acaaggtttt ggttctactt ttttaactgc
     1081 tcatttgctg atgatgactg cagtacactg gagaactgtc tgcctaatgc ttccttgcat
     1141 gaaacaccag ggaaccgttt tgacatggtc atgactgagt ttgcttataa tatgtacaat
     1201 gcggtatacg ctgtggccca cagccttcac aagatgcttc ttcatgaagt agaagtaaga
     1261 gaagtaagaa aggcagaaga cctgatattt tcagcctggc agctgcaccc ttttctgaag
     1321 aacatgcagt ttactaatcc cgctggagaa caagttactt tggatgagaa aatgaaattg
     1381 aatgcagagt atgatattct caactactgg aactttccag aaggtcttca tcttaaggtg
     1441 aaagttggac aattctcccc ttatggtcca cttgatcaac aattatcttt atctgaggac
     1501 ataatagaat ggcccaccga aattacagag actcccaggt ctgtatgcag tgaaagttgt
     1561 ggtcctggat tcagaaaatc cctcccagaa ggaaaaagga tatgttgctt tgactgcatt
     1621 ccatgcccag agaatgaaat ttccaatgag acagatgtgg atcagtgtat gcagtgtcta
     1681 gaccatcaat atgccaacac agcacaaaat cactgcctcc aaaagtctat gaccttcctg
     1741 cattatgaag accccatggg gataagtctg tcctgcatag ccttgtgctt ctctgcactg
     1801 acatctctag ttcttggcat ctttctgaag cagaagaaca ctcccattgt gaaggcaaat
     1861 aaccgcactc tcacctacat cctgctcatt gcccttaact tctgttttct ctgctccttt
     1921 ctcttcattg gccatcccaa cacagtcact tgcatcctgc aacagaccac atttgcagtg
     1981 gtgttcactg tggctgtttc cactgtcttg gccaaaacga ttaccgtggt tctggccttc
     2041 aaggtcaccg ctccaggaag aagaatcagg tggttgttgg taactcgcgc acctaacttc
     2101 atagttccca tctgtacctt gatccaaatt atcttgtgtg gagtctggct gggaaactcc
     2161 cctccgttca ttgacacaga tacacactct gaaaatgaac atattatcat catgtgcaac
     2221 aagggctcag tcactgcctt ctactgtgtg ctgggttacc tgggggctct agccctggga
     2281 agcttcacct tggctttctt ggccaggaac ctacctgaca cgttcaatga agccaagttc
     2341 ctgacattca gcatgctggt gttctgcagt gtctgggtca ccttcctccc tgtctaccac
     2401 agtactaagg ggaagcacat ggtagttgtg gaagtcttct ccatcttggt ctccagtgca
     2461 ggacttctag gctgtatctt tgcccccaag tgctacatta ttttgttaag accacagagg
     2521 aactctcttc agagtcacag gcacaaaata cattataagt atatgactta g
//
LOCUS       NM_001191777             834 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus CIMAP1 family member D (Cimap1d), mRNA.
ACCESSION   NM_001191777 XM_234905
VERSION     NM_001191777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_234905.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760475,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000007.1  10710204-10710330
            128-235             JAXUCZ010000007.1  10711223-10711330
            236-349             JAXUCZ010000007.1  10713269-10713382
            350-834             JAXUCZ010000007.1  10714865-10715349
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..834
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /note="CIMAP1 family member D"
                     /db_xref="GeneID:299600"
                     /db_xref="RGD:1310260"
     CDS             1..834
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /note="outer dense fiber protein 3-like protein 2; outer
                     dense fiber of sperm tails 3-like 2"
                     /codon_start=1
                     /product="protein CIMAP1D"
                     /protein_id="NP_001178706.1"
                     /db_xref="GeneID:299600"
                     /db_xref="RGD:1310260"
                     /translation="MGTLSCDPVARPATVPLARRVADGHIPETGLRKSCGVATLENGS
                     GPGLYVLPSTVGYVNHDCTKAASPAYSLARRPSEAPLQDSSPGPVYFLDPKVTRFGRS
                     CPPAYSMQGRGKIRGLEVTPGPGAYSPEKTPPIRQRNAPAFTLGSRLRQKPPDTSAPA
                     PNAYTMPPLWGSQIFIKPSSPSYTVVGRTPPARPPQDPSETPGPGQYESPDPNTYRQR
                     RPAFSILGRPRTPRPPEDTPGPGTHNPEQVTVNRARAPAYTMGIRHSKRASTMVGDTK
                     C"
     misc_feature    <154..786
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <154..786
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            1..127
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /inference="alignment:Splign:2.1.0"
     exon            128..235
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /inference="alignment:Splign:2.1.0"
     exon            236..349
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /inference="alignment:Splign:2.1.0"
     exon            350..834
                     /gene="Cimap1d"
                     /gene_synonym="Odf3l2; RGD1310260"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggaccc tcagctgcga cccagtggcc aggccagcta cagtgcccct ggctcggcgg
       61 gtggctgatg gccacatccc ggagaccgga ctgaggaagt cctgtggagt ggccaccttg
      121 gagaatggct cgggacctgg cttgtatgtt cttccgtcca ccgttggcta cgtcaatcac
      181 gattgtacca aggcagccag tcctgcctac tcactcgctc ggaggcccag tgaagcaccc
      241 ctccaggatt ccagcccagg acctgtctac ttcttggacc cgaaagttac tcgctttggc
      301 cgtagctgtc cccctgccta ctccatgcag ggccggggta agattagagg tctggaggta
      361 acaccaggcc ctggggccta cagcccagag aagacacccc ccatacgcca gcggaacgcc
      421 ccagctttca cgctgggctc tcgcctccga cagaagcccc cagacacctc tgctcctgcc
      481 cccaatgcct acaccatgcc acccctctgg gggtcacaga tctttatcaa gcctagcagt
      541 cccagctaca cagttgtggg ccgcacaccc cccgcacgcc cccctcagga tccttctgag
      601 actccaggcc ctggacagta cgagagtcct gaccccaaca cctaccggca gcgtaggccg
      661 gccttcagca tactggggag accccgaaca ccacggcccc cggaagacac accgggtcct
      721 ggtacccaca acccggaaca ggtcactgtt aaccgggcca gggccccagc atataccatg
      781 ggcatccgtc actcaaagag ggcatccacc atggtagggg acaccaaatg ctga
//
LOCUS       NM_001099488            2562 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 12 (Vom2r12), mRNA.
ACCESSION   NM_001099488 XM_001074831
VERSION     NM_001099488.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001099488.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  70695506-70695702
            198-489             JAXUCZ010000001.1  70697567-70697858
            490-1290            JAXUCZ010000001.1  70698680-70699480
            1291-1518           JAXUCZ010000001.1  70706627-70706854
            1519-1642           JAXUCZ010000001.1  70715072-70715195
            1643-2562           JAXUCZ010000001.1  70717294-70718213
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2562
                     /gene="Vom2r12"
                     /note="vomeronasal 2 receptor, 12"
                     /db_xref="GeneID:690566"
                     /db_xref="RGD:1594694"
     CDS             1..2562
                     /gene="Vom2r12"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 12 precursor"
                     /protein_id="NP_001092958.3"
                     /db_xref="GeneID:690566"
                     /db_xref="RGD:1594694"
                     /translation="MFTLILSFLLLNIPLQVTGFIYPTCSWRIKENKDKSGNERIGCF
                     FLIQAVQKPVEKEYFSHFFNTQKHTEIHKYSLVLAFSMIEVNRNPDLLPNMSLVFSFR
                     EIICGWQPELSIFIEVNLDDYGVLPNYTCKDDSLCGVVLTGLNWAPTLLLYTILNNFK
                     SQQFPHLTYGHYHPVPSDHENFPYLYQMASDDTSLALALVSFIIHFSWNWIGLAFSDN
                     DQGTHFLSYLKRGMEKNAVCLAFVSMIPVDMHLYMSRAEVYYSQILTSSANVVIIYGD
                     TGSTLAVSFRMWESLGLQRLWITTTQLDVTPSMKENIYGLFAFGHHHGVISGFKNFVQ
                     TLNPVTYSNDNLAKLEWMHFNCEVSASKWKTLKNFSSNHSLEWLMENTFEMTFSEGSY
                     NIYNAVYTVAHVLHKMTFQKFHNLPNAKGKVQNYVCNKLGAPLRKIHFTNPVGDRINM
                     NREDKLQEEYDIFYIWNFPQGLAFKVKIGLFSPYFINGQQLHLSGDMIEWARGSTQMP
                     TSVCSADCGPGFRKFRKKEMSACCFDCSPCPENEISNETNMEMCVLCPEDKYANTGQN
                     DCIPKALIFLSYEDHLGMALSLMALGFSAFTAVVLGIFVKHHSTPIVKANNRTLTYIL
                     LLSLIFCFLCPLLFIGHPDSVTCILQQITFGVLFTVAISTVLAKTITVILAFKVTAPQ
                     RMMKYFLLSGVSMYIIPICTLIQVIVCAVCLGVSPPSVDIDAQSEHGHIIVVCNNGSV
                     TCFYSVLGYLACLTFVSFTLAFLSRNLPGAFNEAKSITFSMLVVCSVWVTFLPVYHST
                     KGKIMVAVEIISILASSSGMLVCIFIPKCYIILFRPEKNSLKMIREKSPSHTHIS"
     sig_peptide     1..57
                     /gene="Vom2r12"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    121..1500
                     /gene="Vom2r12"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1500
                     /gene="Vom2r12"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1168..1170)
                     /gene="Vom2r12"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1168..1170)
                     /gene="Vom2r12"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,460..462,730..732)
                     /gene="Vom2r12"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(331..333,340..342,460..462,730..732)
                     /gene="Vom2r12"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1522..1683
                     /gene="Vom2r12"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1522..1683
                     /gene="Vom2r12"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1744..2496
                     /gene="Vom2r12"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..2496
                     /gene="Vom2r12"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..1818
                     /gene="Vom2r12"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1744..1818
                     /gene="Vom2r12"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r12"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r12"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r12"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r12"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r12"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r12"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r12"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r12"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r12"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r12"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r12"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r12"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r12"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r12"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r12"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r12"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
     exon            198..489
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1290
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1518
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1642
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2562
                     /gene="Vom2r12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcactc tgattttgtc tttcttgctc ctgaacattc cacttcaggt gactggtttt
       61 atttatccca cctgctcttg gagaataaaa gagaataaag acaagagtgg aaacgagaga
      121 attggctgtt tcttcttgat tcaagcagta caaaagcctg tggagaaaga gtatttcagt
      181 cattttttca acacacaaaa acacactgaa atccacaagt attctcttgt cttggctttt
      241 tccatgattg aagtcaacag gaaccctgat cttttgccaa atatgtctct agtattttca
      301 tttcgagaaa taatttgtgg ttggcaaccc gaattatcaa ttttcattga agtgaattta
      361 gatgattatg gagttctccc taattatacc tgtaaagatg acagtctgtg tggagtggta
      421 cttacaggat taaactgggc accaactctg ttactttata caatcctaaa caacttcaaa
      481 tctcagcagt tccctcatct tacttacgga cactatcatc ctgttccgag tgatcatgaa
      541 aattttccct atctatatca gatggcctct gatgatacat ctctagccct tgccctggtc
      601 tcattcataa ttcattttag ttggaactgg atagggttgg ccttctcaga caatgatcaa
      661 gggacccatt ttctctctta tttgaaaaga gggatggaaa aaaatgcagt ctgtcttgct
      721 tttgtgagca tgatcccagt cgatatgcat ttatacatgt caagagctga agtgtattac
      781 agccaaatct tgacatcatc cgcaaatgtt gttatcattt atggcgacac aggcagtact
      841 ttagctgtga gttttagaat gtgggaatct ctaggtttac agagattatg gatcaccacc
      901 acacagttgg atgtcactcc tagcatgaaa gaaaatatat atgggttatt tgcttttgga
      961 caccaccatg gtgtgatttc tggttttaaa aattttgtcc agacattgaa tcctgtcaca
     1021 tactcaaatg acaatctggc aaagctggaa tggatgcact ttaactgtga agtctcagca
     1081 tcgaaatgga agacactgaa gaacttttca tctaatcact cactggaatg gctaatggaa
     1141 aatacttttg aaatgacctt tagtgaagga agttataaca tatacaatgc tgtgtatact
     1201 gttgcgcatg tacttcataa gatgactttt caaaagtttc ataatctgcc caatgccaaa
     1261 gggaaagtac aaaattatgt ctgcaataag ctgggtgccc ctctgagaaa gatccacttc
     1321 actaatccag ttggggacag aataaatatg aatcgagaag acaaactgca ggaagaatat
     1381 gacattttct acatttggaa ttttccacag ggacttgcat ttaaagtgaa aataggacta
     1441 tttagtccct attttataaa tggtcaacag ttacatttat ctggagatat gatagagtgg
     1501 gcaagaggaa gtacacagat gccgacctct gtgtgcagtg ctgattgtgg tccaggattt
     1561 agaaaattca gaaagaagga aatgtcagcc tgttgttttg attgcagtcc ctgcccagaa
     1621 aatgaaattt ctaatgagac aaacatggag atgtgtgtcc tgtgcccaga ggacaaatat
     1681 gccaacacag gacagaatga ctgcattcca aaagctctta tctttctcag ttatgaagac
     1741 cacctgggga tggcactttc tttaatggcc ctgggcttct ctgcattcac agctgtggtt
     1801 cttggcatct ttgtgaagca ccacagtact cccattgtta aggccaataa cagaactctc
     1861 acttacatct tgctcctctc cctcattttt tgtttccttt gccccttgct cttcattggg
     1921 catccagact cggtcacatg catcctacag caaatcacat ttggagttct attcaccgtg
     1981 gctatttcca cagtgttagc caaaacaatt actgttattc tggcattcaa agtcacagcc
     2041 cctcaaagaa tgatgaagta ctttcttctt tcaggagtat ctatgtacat cattcccatc
     2101 tgcactctca tccaagttat tgtctgtgca gtctgtttag gagtttctcc tccttctgtt
     2161 gacattgatg ctcaatctga gcatggtcac attatcgttg tttgcaacaa tggttcagtt
     2221 acttgttttt acagtgttct gggatacctg gcctgcctga cctttgtgag cttcactctg
     2281 gctttccttt ccagaaacct gcctggtgcc ttcaatgaag ccaagtcaat aacattcagc
     2341 atgctggtgg tctgcagtgt ctgggttact ttcctccccg tttaccatag cacaaaaggc
     2401 aagatcatgg tggctgttga gatcatttcc attttggctt ccagttcagg gatgctggta
     2461 tgcattttca ttcccaaatg ttacataata ctttttagac cagaaaaaaa ttctcttaaa
     2521 atgatcaggg agaaatcacc ttcccatact cacatttcat aa
//
LOCUS       NM_001099459            2526 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 6 (Vom2r6), mRNA.
ACCESSION   NM_001099459 XM_001067478 XM_218121
VERSION     NM_001099459.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001099459.2.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMN17050755
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  3025923-3026128
            207-489             JAXUCZ010000001.1  3028690-3028972
            490-1293            JAXUCZ010000001.1  3029373-3030176
            1294-1518           JAXUCZ010000001.1  3031024-3031248
            1519-1642           JAXUCZ010000001.1  3032423-3032546
            1643-2526           JAXUCZ010000001.1  3033710-3034593
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..2526
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="vomeronasal 2 receptor, 6"
                     /db_xref="GeneID:308257"
                     /db_xref="RGD:1562697"
     CDS             1..2526
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 6 precursor"
                     /protein_id="NP_001092929.3"
                     /db_xref="GeneID:308257"
                     /db_xref="RGD:1562697"
                     /translation="MKKLCAFTIAFFSLKFCLILCSLTEPNCFWRIKKSEDNDGDLRS
                     DCGFVLFTDEDPIEEDFYNRIINFRIPGRKYEFFLVLFFATDEINKNPNLLSNMSLSF
                     SIIVGLCEDTLGVLEKAYSHKNNNFELINYYCRMKQCCDVELTGPSWTTSLKLSIYSR
                     KPKIFFGSFNPNLSDHDQFPYIYQIAAKDTYLFHGMVSLMFHFGWTWIGLVISDDDQG
                     IQFLSDLREEIQRHEICLAFVNMIPETMQIFKTRLKIYDQQLMTSSAKVVVIYGEMNS
                     TLELSFRRWAYLGAQRIWITTSQWDVTTHKKDFSLDFFHGTVTFAHHHNDIAVFRNFM
                     QTINTSKYPIDISQSMLHWNHFNCSISKNNNKMDCLTFNNSLEWLAQHTFDMALSDEG
                     YNLYNAVYAVAHTYHELIFQQVESQKMEEPKGICADCQQVASLLKTRVFTNPVGELVN
                     MNHKENQCAKYDIFMIWNFPQGLGLKVKIGSYFPCLPQSQQLHISENWEWVTGETVVP
                     SSVCSVTCTAGFRKIHQKQTADCCFDCVQCQENEIANDTDMEQCVRCPDDSYANLEQT
                     QCLQRAVTFLAYEDPLGMALGCMALSFSAITTLVLVTFVKYRDTPIVKANNRILSYIL
                     LISLVFCFLCSLLFIGHPNQATCILQQTTFAIFFTVAISTVLAKTITVVTAFKLTTPG
                     RRIRRMMIKGATNLLIPICTLIQLVLCGIWLVTSPPFIDRDTQSEHGKIVIICNKGSD
                     IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLVFYSVWITFLPVYHST
                     RGKVMVVVEVFSILASCAGLLGCIFVQKCYILLFRTDLNFLQK"
     sig_peptide     1..78
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    133..1500
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    133..1500
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,499..504,1171..1173)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1522..1683
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1522..1683
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1741..2496
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1741..2496
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1741..1818
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1741..1818
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1750..1752,1759..1764,1771..1776,1780..1785,
                     1885..1887,1897..1899,1906..1911,1933..1935,1945..1947)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1852..1917
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1912..1914,1948..1953,1960..1965,1972..1974,
                     2212..2214,2227..2229,2236..2241,2248..2250,2350..2352,
                     2359..2364,2371..2373,2383..2385,2407..2412,2419..2421,
                     2428..2430,2440..2442)
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1942..2016
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2086..2136
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2215..2295
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2317..2388
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2401..2478
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
     exon            207..489
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1293
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1518
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1642
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2526
                     /gene="Vom2r6"
                     /gene_synonym="RGD1562697"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaagc tgtgtgcttt cactattgcc tttttttccc tgaagttttg tctcatcttg
       61 tgcagtttga ctgaacccaa ttgcttttgg aggataaaga agagcgaaga taatgatgga
      121 gatttgcgaa gtgactgtgg ttttgttctt tttacagacg aggaccctat tgaagaagat
      181 ttttataatc gcattattaa ttttagaata ccaggaagaa aatatgagtt ttttctggta
      241 ctgttttttg ctactgatga gatcaacaag aatcctaatc ttttatccaa catgtctttg
      301 tcattttcca tcattgttgg cctgtgtgaa gatacattgg gagttctgga aaaagcatat
      361 tcacataaaa acaacaattt cgaactaatt aattattact gtagaatgaa gcaatgttgt
      421 gatgtagaac ttacaggacc atcatggaca acttccttaa aactgtcaat ttattcaagg
      481 aaaccaaaga ttttctttgg atcatttaac cctaacctga gtgaccatga ccagtttccc
      541 tatatctatc agatagcagc caaggacaca tatttgttcc atggcatggt ctccttgatg
      601 tttcattttg gatggacttg gataggactg gtcatctcag atgatgacca aggtattcag
      661 tttctctcag acttgagaga agaaatacaa aggcatgaaa tctgtttagc ttttgtgaat
      721 atgatcccag aaaccatgca gatattcaag acaagactta agatatatga ccaacaactt
      781 atgacatctt cagcaaaggt tgttgtcatt tatggtgaaa tgaactccac tctagaactc
      841 agctttagaa gatgggcata tttaggtgca cagagaatct ggatcacaac ctcacaatgg
      901 gatgtcacca cacataaaaa agatttcagc cttgatttct tccacgggac tgtcactttt
      961 gcccaccacc acaatgacat tgctgtattt aggaatttta tgcaaacaat aaacacatcc
     1021 aagtatccaa tagacatttc acagtctatg ctgcactgga atcattttaa ctgttcaatc
     1081 tcaaagaaca ataacaaaat ggattgttta acattcaaca actcattgga atggttagca
     1141 cagcacacgt ttgacatggc cctgagtgat gaaggttaca atttgtataa tgctgtgtat
     1201 gctgttgccc acacctacca tgaactcatt tttcaacaag tagagtctca gaaaatggaa
     1261 gaacccaaag gaatatgcgc tgactgtcag caggtggctt ctttgctgaa aactagggtg
     1321 tttactaacc ctgttggaga actggtgaac atgaatcata aggaaaatca gtgtgccaag
     1381 tatgacattt tcatgatttg gaattttcca caaggccttg gattaaaagt gaaaatagga
     1441 agctattttc cttgtttgcc acagagtcaa caacttcata tatctgaaaa ctgggagtgg
     1501 gtcacaggag aaacagtggt tccctcctca gtgtgtagtg tgacatgtac tgcaggattc
     1561 agaaaaattc atcagaaaca aacagctgat tgctgctttg attgtgtcca gtgccaagaa
     1621 aatgagattg ccaatgatac agatatggaa cagtgtgtga ggtgtcctga tgattcgtat
     1681 gccaacttag aacaaaccca gtgcctccaa agagctgtga catttcttgc ttatgaagat
     1741 ccactgggga tggctctagg ctgcatggcc ctgtccttct cagccatcac aactctagta
     1801 ctagtcactt ttgtgaagta cagggatact cccattgtga aagccaataa ccgcattctc
     1861 agctatatcc tactcatatc tctagtcttc tgttttctct gttcattgct cttcattgga
     1921 catcccaacc aggccacctg catcctgcag cagaccacat ttgcaatatt tttcactgtt
     1981 gctatttcta ctgtgttggc caaaacaata actgtggtca cagctttcaa gctcactact
     2041 ccagggagaa ggataagaag gatgatgata aagggggcaa ctaacttgct cattcccatt
     2101 tgtaccctaa tccaacttgt cctctgtgga atctggttgg tgacatctcc tccatttatt
     2161 gacagagata cacaatctga acatgggaag atagtcatca tttgcaacaa aggctcagac
     2221 attgccttcc actttgtctt gggatatttg ggctccttgg ctctggggag cttcactgtg
     2281 gctttcttgg ctaggaacct tcctgacaga ttcaatgagg ccaagttcct aacattcagc
     2341 atgttggtct tctacagtgt ttggatcacc ttcctccctg tctaccacag caccaggggg
     2401 aaggttatgg ttgttgttga ggttttctct atcttggctt cctgtgcagg gttgctaggg
     2461 tgcatatttg tccaaaagtg ttatattctt ttatttcgaa cagatttaaa ttttcttcag
     2521 aaataa
//
LOCUS       NM_001106148            2206 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus myotilin (Myot), transcript variant 1, mRNA.
ACCESSION   NM_001106148 XM_001053135 XM_001053210 XM_214563
VERSION     NM_001106148.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   von Nandelstadh,P., Ismail,M., Gardin,C., Suila,H., Zara,I.,
            Belgrano,A., Valle,G., Carpen,O. and Faulkner,G.
  TITLE     A class III PDZ binding motif in the myotilin and FATZ families
            binds enigma family proteins: a common link for Z-disc myopathies
  JOURNAL   Mol Cell Biol 29 (3), 822-834 (2009)
   PUBMED   19047374
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Hauser,M.A., Horrigan,S.K., Salmikangas,P., Torian,U.M.,
            Viles,K.D., Dancel,R., Tim,R.W., Taivainen,A., Bartoloni,L.,
            Gilchrist,J.M., Stajich,J.M., Gaskell,P.C., Gilbert,J.R.,
            Vance,J.M., Pericak-Vance,M.A., Carpen,O., Westbrook,C.A. and
            Speer,M.C.
  TITLE     Myotilin is mutated in limb girdle muscular dystrophy 1A
  JOURNAL   Hum Mol Genet 9 (14), 2141-2147 (2000)
   PUBMED   10958653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474178.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053135.1, XM_001053210.1, XM_214563.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2206
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="myotilin"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
     exon            1..85
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="upstream in-frame stop codon"
     exon            86..623
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1761
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="isoform 1 is encoded by transcript variant 1; titin
                     immunoglobulin domain protein (myotilin)"
                     /codon_start=1
                     /product="myotilin isoform 1"
                     /protein_id="NP_001099618.1"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
                     /translation="MFNYERPKHFIQSQNPCGSGLQPPGPEVSSFPNQTKQSSIVIQP
                     RQCTEQRFSASSTVSSHITVSSSAYPASQQLAGPNPGQKVTATYNQSPASFLSSILPS
                     QPDYSNSKIPSTVDSNYQQSSVHQPVNAVSSQAAGAKPTPRTPDHEIQGSKEALIQDL
                     ERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDVQDSSQHNPEHARL
                     QVPTSQVRSRSSSRADANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLPA
                     PDVSWYLNGRLVQSDELHKMIVSEKGFHSLIFEVVRASDAGPYACVARNRAGEATFTV
                     QLDVLAKEHKRAPMFIYKPQSKKVFEGESVKLECQISAIPPPKLFWKRNNEMVQFNTD
                     RISLYHDNAGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTPPAPK
                     QLRVRPTFSKYLALNGKGLDVKQAFNPEGEFQRLAAQSGLYESEEL"
     misc_feature    1012..1284
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1012..1284
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1063..1077
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1063..1077
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1102..1116
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1102..1116
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1180..1194
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1180..1194
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1222..1239
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1222..1239
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1261..1272
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1261..1272
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1309..1584
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1309..1584
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1309..1320
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1309..1320
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1327..1344
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1327..1344
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1357..1380
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1357..1380
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1399..1419
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1399..1419
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1420..1431
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1420..1431
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1450..1470
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1450..1470
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1477..1509
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1477..1509
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1519..1545
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1519..1545
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1549..1584
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     misc_feature    1549..1584
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     exon            624..798
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            799..900
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            901..947
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1080
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1288
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1454
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1588
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2206
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccacac gatcctgagc aaggagatgc ttcttccttc tcttcagtag tgggttgaga
       61 caagctggcc ccttctgagc taaggaaaca atatccttca agagaaaccc accaacatca
      121 ggagtacagt gttctagaga tctcagcaag gagggccaga ctaaggtttc ttctgacttg
      181 ctgcaacctt ctgtaattcc aggcttgcca ccccacggtc aggagtctat ccttctggga
      241 gcaaatccat cttccatata ccagctaagc atgtttaact acgaacgtcc aaaacacttc
      301 atccagtccc aaaatccatg tggctccggg ctgcagcctc caggacctga agtctccagc
      361 ttccctaacc agaccaaaca gtcttccatc gtcatccagc ctcgccaatg caccgagcag
      421 agattttctg cttcctccac agtgagctct cacatcaccg tgtcttcctc tgcttatcct
      481 gcttcccagc agctggctgg ccccaacccc ggtcagaagg ttactgctac ctataaccag
      541 tccccagcca gcttcctcag ttctatatta ccgtctcagc ctgattacag taacagtaaa
      601 atcccatcca ctgtggactc caactatcaa caatcctcag ttcaccaacc tgtaaatgcc
      661 gtgtcatccc aagctgcagg tgctaagccc actccaagga ctcctgacca cgaaatccaa
      721 ggatcaaaag aagcattgat tcaagatttg gaaagaaagc tgaaatgcaa agacaccctt
      781 cttcataatg gaaaccaaag actgacctat gaggagaaga tggctcgcag gttgttagga
      841 ccgcagaatg ctgctgctgt gtttcaagct caaaacagtg acgtccaaga ttcgtcacag
      901 cataacccag aacatgcacg gctgcaagtt cccacatcac aagtaagaag tagatcgtcc
      961 tccagagcag acgcaaatga ccaggatgcc atccaggaga agttttaccc accacgcttc
     1021 attcaagtgc cagaaaatat gtccatcgaa gaaggaagat tctgcagaat ggactttaaa
     1081 gtgagtggac tgccagcccc tgatgtgtca tggtatctaa acgggagact ggtgcaatca
     1141 gatgagttgc acaaaatgat agtgtcagag aagggtttcc actccctcat ctttgaagtg
     1201 gtcagagcat cagatgcagg gccatatgca tgtgtagcca gaaacagagc tggagaagcc
     1261 accttcacag tgcagctgga tgttctggca aaagagcaca aaagagcacc gatgtttatc
     1321 tacaaaccac agagcaaaaa ggtttttgag ggagaatcag tgaagttaga gtgccagatc
     1381 tcagctatcc ctccaccaaa gcttttctgg aaaagaaaca acgaaatggt tcagttcaac
     1441 actgaccgga taagcttata tcatgataat gctggaagag taactttact gataaaagat
     1501 gtaaacaaga aggatgctgg gtggtataca gtgtcagcag tcaatgaagc tggcgtgacc
     1561 acgtgtaaca caagattaga tgtcacagcc cgtccaaacc aaactccccc agctcctaag
     1621 caactgcgtg ttcgaccaac tttcagcaaa tatttagccc taaatgggaa aggtttggat
     1681 gtgaaacaag ctttcaaccc tgaaggagag tttcagcgtc tggcagctca atccggactc
     1741 tatgaaagtg aagaacttta ataactttgc ccacagggaa aacagagctt cactcctcca
     1801 atggatctga taacattgtg aaaaaaaatc catggttgta ttaacagatt gtgactttac
     1861 ttaggtcata tactaactcc catttagaat gttattcacc ctctgactct ggcacaacgt
     1921 gtctattcct ctgacctgtg aagccggcag taaactaagt aaatgagttt gtattataag
     1981 agactgtttt aagatacagt gtcttaacac tgaagtcatg cacatttaac aactatgagt
     2041 tatgaaccag aaacttttta aatgccacta attcttgcag taaagtgtat gggtattgcc
     2101 taacagactt tatttacctg ttttctctta taggaatact aacatggtat agattatctg
     2161 agtgttccac aatttcatgt caaaagagaa taaaattcaa gtagtt
//
LOCUS       NM_001167572             906 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 17 (Vom1r17), mRNA.
ACCESSION   NM_001167572
VERSION     NM_001167572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               JAXUCZ010000001.1  69443172-69444077
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..906
                     /gene="Vom1r17"
                     /note="vomeronasal 1 receptor 17"
                     /db_xref="GeneID:100312945"
                     /db_xref="RGD:2316476"
     CDS             1..906
                     /gene="Vom1r17"
                     /note="vomeronasal 1 receptor Vom1r17; vomeronasal type-1
                     receptor 4-like; vomeronasal V1r-type receptor V1rf4;
                     vomeronasal type-1 receptor 3-like"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 17"
                     /protein_id="NP_001161044.1"
                     /db_xref="GeneID:100312945"
                     /db_xref="RGD:2316476"
                     /translation="MNASELSIGVIILSQTVIGVLANFFLLYHCMILYLTRYRLRSID
                     CVLMQLSVANILTILSKGIPQTIAAFGLKDFLNDIGCKLTFFVHKVGKSVCIGSTSFL
                     SVLQAIIISPKDSRCPKLKVKVRKYICYSVWVIFFIISILNLLHLRAPYTNESTITLK
                     SFVYCYCVRHDPTSDILHAVLVSGPDIIFLGLMLYTSGFTVLTLYRHKQKMQQMPRMN
                     VSSISSPASRATKTILLLVSTFVSFYTISTLCHLLVVILYNPSWILVNVAAMSASFFP
                     TVYPFLLMSHDSWALSFCLLLKRNR"
     misc_feature    22..861
                     /gene="Vom1r17"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..861
                     /gene="Vom1r17"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    22..96
                     /gene="Vom1r17"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    22..96
                     /gene="Vom1r17"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:410628"
     misc_feature    130..195
                     /gene="Vom1r17"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    130..195
                     /gene="Vom1r17"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Vom1r17"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    244..312
                     /gene="Vom1r17"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    388..429
                     /gene="Vom1r17"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    388..429
                     /gene="Vom1r17"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    532..603
                     /gene="Vom1r17"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    532..603
                     /gene="Vom1r17"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    688..756
                     /gene="Vom1r17"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    688..756
                     /gene="Vom1r17"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    784..861
                     /gene="Vom1r17"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    784..861
                     /gene="Vom1r17"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            1..906
                     /gene="Vom1r17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatgcca gtgaactgtc tataggagtg atcatcttgt ctcagactgt gattggagtt
       61 ttggctaatt tctttctcct ctaccactgt atgattcttt acttaacaag gtacaggttg
      121 aggtctatag actgtgttct gatgcagtta agtgtagcca acatcttaac aattctgtcc
      181 aaaggcatac cccagacaat tgcagctttt ggcttgaaag acttcctcaa tgatattgga
      241 tgcaaactga ctttctttgt tcacaaagta ggtaaaagtg tttgtattgg tagcacttcc
      301 tttctcagtg tactccaggc catcatcatc agtcccaagg attccagatg tccaaagctt
      361 aaagtaaaag tgcgcaagta tatttgttat tctgtgtggg tgatcttttt cattataagc
      421 attcttaatc ttttgcatct gagggcacca tataccaatg aaagtacaat aactctgaaa
      481 tcttttgtat actgctattg tgttcgtcat gacccaacca gtgacatcct acatgcagta
      541 ttggtgtcag gtcctgacat aattttccta ggtctcatgc tgtacaccag tggcttcacg
      601 gttctaaccc tgtataggca taagcaaaag atgcaacaaa tgcccaggat gaatgtttct
      661 tctatatcct cccctgcatc cagagccacc aaaacaatcc ttctcctagt cagtactttt
      721 gtctcctttt acacaatctc tactctatgt catctcttag tagttatctt gtataatccc
      781 agctggattc tagtgaatgt ggctgcaatg tctgcttcgt ttttccccac tgtttatccc
      841 tttctcctca tgagccatga ttcttgggca ctcagcttct gcctgctctt gaaaaggaat
      901 aggtaa
//
LOCUS       NM_001163921            1689 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus EF-hand and coiled-coil domain containing 1
            (Efcc1), mRNA.
ACCESSION   NM_001163921 XM_001062782 XM_001062901 XM_001075064 XM_001075115
VERSION     NM_001163921.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Aug 8, 2009 this sequence version replaced
            XM_001062782.1, XM_001062901.1, XM_001075064.1, XM_001075115.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               JAXUCZ010000004.1  121745815-121746486
            673-935             JAXUCZ010000004.1  121747534-121747796
            936-1066            JAXUCZ010000004.1  121764609-121764739
            1067-1205           JAXUCZ010000004.1  121766042-121766180
            1206-1336           JAXUCZ010000004.1  121767168-121767298
            1337-1488           JAXUCZ010000004.1  121769731-121769882
            1489-1552           JAXUCZ010000004.1  121772087-121772150
            1553-1689           JAXUCZ010000004.1  121773042-121773178
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1689
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /note="EF-hand and coiled-coil domain containing 1"
                     /db_xref="GeneID:685202"
                     /db_xref="RGD:1596494"
     exon            1..672
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1689
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /note="coiled-coil domain containing 48 like; coiled-coil
                     domain containing 48-like1; EF-hand domain-containing
                     protein ENSP00000381169 homolog"
                     /codon_start=1
                     /product="EF-hand and coiled-coil domain-containing
                     protein 1"
                     /protein_id="NP_001157393.1"
                     /db_xref="GeneID:685202"
                     /db_xref="RGD:1596494"
                     /translation="MESSAGDPYRRPARRAQWLLSALAHHYGLDRGVENEIVVLATGL
                     DQYLQEVFHHLDCRGAGRLPRADFRALCAVLGLNADGEAAKEDANSTEVAAKNPATGM
                     IAGGDADVREEALLALRADPPELTFRQFHARLCGYFSSRAGSRLPRGALSEHIETQIR
                     LRRPRRRRRPGSPSLHGGAYGERVAHLEEENSSLRELVEDLRAALQSSDARCLALQVG
                     LWKSQSDIPEAAAHELQRAQGALAEAEARARRLQRGQVEVRLRTEEARQAVRRSLHRV
                     RELESLARRVPRLQRQVQRLEAELRRYRSEGPQLLTPPQTSPRPGNKNGEPTARGTRD
                     SDTTSEGVLQSDTKEEQLFRSVEGQAASEEEEEERWQEKPGRPQAHSEVPLMQPSGCV
                     NRCDDQTAETLKASFGHCDGAEHVCTLELEPHVTRLGEQLQTLGCNPFYQAELQQMVE
                     TEHLRLELQMVETERVRLSLMEEKLVDVLQLLQRLRDLNISKRALGKMLLNALDQNPS
                     QEGTRGTLAILDTLHQALVGCELLQRNPSAPASKAPAHTNPFLVSC"
     misc_feature    43..1683
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /note="Coiled-coil domain-containing protein 48; Region:
                     CCD48; pfam15799"
                     /db_xref="CDD:464878"
     misc_feature    43..1683
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /note="Coiled-coil domain-containing protein 48; Region:
                     CCD48; pfam15799"
                     /db_xref="CDD:464878"
     exon            673..935
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1066
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1205
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1336
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1488
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1552
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1689
                     /gene="Efcc1"
                     /gene_synonym="Ccdc48; Ccdc48l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggagcc gccgaggtcg aggcatggag agctcggcgg gagacccata ccggcggccc
       61 gcgcggcgtg ctcagtggct gctgagcgcc ttggctcacc attacgggct ggaccgcggc
      121 gtggagaacg agatcgtggt gctggctacc ggtctggacc agtatctgca ggaggtcttc
      181 caccacttgg actgccgggg cgctggccgc ctgccgcgcg ccgacttccg tgcactctgc
      241 gcggtcctgg gactgaacgc tgatggggag gcggccaagg aagacgcaaa ctccacggag
      301 gtggccgcca agaacccggc tactgggatg atcgctggcg gagacgcgga cgtcagggaa
      361 gaggcgctcc tggctttgcg ggccgatcct cctgaactca ccttccgcca gttccacgcg
      421 cgcctctgtg gctacttcag tagtcgagcg gggtcccggc tgcctcgcgg agctctgagc
      481 gagcacatcg agacgcagat ccgcctccgc cgtccgcgcc gccgccgccg gcctggctca
      541 ccgagcctgc acggtggcgc ctatggcgag cgcgtggcac atctagagga ggaaaacagt
      601 agcctacgcg agttggtgga ggacctacgt gctgcgctgc agagcagtga cgcgcgctgc
      661 ctggcccttc aggtcggcct ctggaaaagc cagtcggaca tcccggaagc ggcggcgcac
      721 gagctgcagc gagctcaggg agcgctggca gaggcggagg cgcgcgctcg acggctgcag
      781 cgaggacagg tggaggtgcg gctgcgcact gaggaggccc ggcaggcggt ccggcgcagc
      841 ttgcaccgag tgcgagagct ggagtcgctg gcgcggcgcg ttccccgctt gcagcgccaa
      901 gtgcagcgac tggaggcaga gcttagacgt taccggtcag aagggcctca gctcctaaca
      961 cccccacaaa ctagtccaag gccaggaaac aagaatggtg aacctacggc tagaggcacc
     1021 agagattcag acaccacttc agagggagtc ctgcagtcag acaccaagga agaacagctg
     1081 ttccgctccg tggaaggcca ggctgcctct gaggaggaag aggaagaaag gtggcaggaa
     1141 aagccagggc gcccacaggc ccacagcgag gtacccctga tgcaaccctc aggctgtgtg
     1201 aacaggtgtg atgaccagac agctgagacg ctcaaggctt ccttcggcca ctgtgatggt
     1261 gctgagcacg tctgcaccct agagctggaa cctcatgtca ccaggcttgg ggaacagctg
     1321 cagaccctgg gctgcaaccc tttctaccag gcagaactgc agcagatggt ggaaactgag
     1381 catctgaggc tggagctgca gatggtggag acggagaggg tccggctgtc gctgatggaa
     1441 gagaagttgg tggatgtgct acaactcctg cagaggctcc gggacctgaa catatcaaaa
     1501 agagcactgg ggaagatgct gctgaatgcc ctggaccaga acccctcaca ggagggtaca
     1561 cggggcacct tggccatcct ggacaccttg caccaagcct tagttggctg tgagctccta
     1621 cagagaaacc cctcagcacc agcatccaag gctcctgcac atacgaaccc cttcctcgtc
     1681 tcctgctga
//
LOCUS       NM_001191683            2750 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus BCL11 transcription factor A (Bcl11a), mRNA.
ACCESSION   NM_001191683 XM_223693
VERSION     NM_001191683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Zhang,Y., Shen,Y., Zhao,L., Zhao,Q., Zhao,L. and Yi,S.
  TITLE     Transcription Factor BCL11A Regulates Schwann Cell Behavior During
            Peripheral Nerve Regeneration
  JOURNAL   Mol Neurobiol 60 (9), 5352-5365 (2023)
   PUBMED   37316757
  REMARK    GeneRIF: Transcription Factor BCL11A Regulates Schwann Cell
            Behavior During Peripheral Nerve Regeneration.
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Basak,A., Hancarova,M., Ulirsch,J.C., Balci,T.B., Trkova,M.,
            Pelisek,M., Vlckova,M., Muzikova,K., Cermak,J., Trka,J.,
            Dyment,D.A., Orkin,S.H., Daly,M.J., Sedlacek,Z. and Sankaran,V.G.
  TITLE     BCL11A deletions result in fetal hemoglobin persistence and
            neurodevelopmental alterations
  JOURNAL   J Clin Invest 125 (6), 2363-2368 (2015)
   PUBMED   25938782
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Al-Allawi,N.A., Puehringer,H., Raheem,R.A. and Oberkanins,C.
  TITLE     Genetic Modifiers in beta-Thalassemia Intermedia: A Study on 102
            Iraqi Arab Patients
  JOURNAL   Genet Test Mol Biomarkers 19 (5), 242-247 (2015)
   PUBMED   25751242
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   De Rubeis,S., He,X., Goldberg,A.P., Poultney,C.S., Samocha,K.,
            Cicek,A.E., Kou,Y., Liu,L., Fromer,M., Walker,S., Singh,T.,
            Klei,L., Kosmicki,J., Shih-Chen,F., Aleksic,B., Biscaldi,M.,
            Bolton,P.F., Brownfeld,J.M., Cai,J., Campbell,N.G., Carracedo,A.,
            Chahrour,M.H., Chiocchetti,A.G., Coon,H., Crawford,E.L.,
            Curran,S.R., Dawson,G., Duketis,E., Fernandez,B.A., Gallagher,L.,
            Geller,E., Guter,S.J., Hill,R.S., Ionita-Laza,J., Jimenz
            Gonzalez,P., Kilpinen,H., Klauck,S.M., Kolevzon,A., Lee,I., Lei,I.,
            Lei,J., Lehtimaki,T., Lin,C.F., Ma'ayan,A., Marshall,C.R.,
            McInnes,A.L., Neale,B., Owen,M.J., Ozaki,N., Parellada,M.,
            Parr,J.R., Purcell,S., Puura,K., Rajagopalan,D., Rehnstrom,K.,
            Reichenberg,A., Sabo,A., Sachse,M., Sanders,S.J., Schafer,C.,
            Schulte-Ruther,M., Skuse,D., Stevens,C., Szatmari,P., Tammimies,K.,
            Valladares,O., Voran,A., Li-San,W., Weiss,L.A., Willsey,A.J.,
            Yu,T.W., Yuen,R.K., Cook,E.H., Freitag,C.M., Gill,M., Hultman,C.M.,
            Lehner,T., Palotie,A., Schellenberg,G.D., Sklar,P., State,M.W.,
            Sutcliffe,J.S., Walsh,C.A., Scherer,S.W., Zwick,M.E., Barett,J.C.,
            Cutler,D.J., Roeder,K., Devlin,B., Daly,M.J. and Buxbaum,J.D.
  CONSRTM   DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K
            Consortium
  TITLE     Synaptic, transcriptional and chromatin genes disrupted in autism
  JOURNAL   Nature 515 (7526), 209-215 (2014)
   PUBMED   25363760
REFERENCE   5  (bases 1 to 2750)
  AUTHORS   Chu,N.L., Wu,Z.K., Zhang,X.H., Fang,S.P., Wang,W.J. and Cheng,Y.L.
  TITLE     Molecular mechanism of yisui shengxue granule, a complex chinese
            medicine, on thalassemia patients suffering from hemolysis and
            anemia of erythrocytes
  JOURNAL   Evid Based Complement Alternat Med 2014, 213782 (2014)
   PUBMED   25574177
REFERENCE   6  (bases 1 to 2750)
  AUTHORS   Lettre,G., Sankaran,V.G., Bezerra,M.A., Araujo,A.S., Uda,M.,
            Sanna,S., Cao,A., Schlessinger,D., Costa,F.F., Hirschhorn,J.N. and
            Orkin,S.H.
  TITLE     DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci
            associate with fetal hemoglobin levels and pain crises in sickle
            cell disease
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11869-11874 (2008)
   PUBMED   18667698
REFERENCE   7  (bases 1 to 2750)
  AUTHORS   Kuo,T.Y. and Hsueh,Y.P.
  TITLE     Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in
            rat brain
  JOURNAL   J Neurosci Res 85 (8), 1628-1636 (2007)
   PUBMED   17455301
  REMARK    GeneRIF: regional and subcellular distributions of
            Bcl11A/Evi9/CTIP1 in rat brain were investigated by immunostaining
            and biochemical fractionation
REFERENCE   8  (bases 1 to 2750)
  AUTHORS   Liu,P., Keller,J.R., Ortiz,M., Tessarollo,L., Rachel,R.A.,
            Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Bcl11a is essential for normal lymphoid development
  JOURNAL   Nat Immunol 4 (6), 525-532 (2003)
   PUBMED   12717432
REFERENCE   9  (bases 1 to 2750)
  AUTHORS   Satterwhite,E., Sonoki,T., Willis,T.G., Harder,L., Nowak,R.,
            Arriola,E.L., Liu,H., Price,H.P., Gesk,S., Steinemann,D.,
            Schlegelberger,B., Oscier,D.G., Siebert,R., Tucker,P.W. and
            Dyer,M.J.
  TITLE     The BCL11 gene family: involvement of BCL11A in lymphoid
            malignancies
  JOURNAL   Blood 98 (12), 3413-3420 (2001)
   PUBMED   11719382
REFERENCE   10 (bases 1 to 2750)
  AUTHORS   Avram,D., Fields,A., Pretty On Top,K., Nevrivy,D.J., Ishmael,J.E.
            and Leid,M.
  TITLE     Isolation of a novel family of C(2)H(2) zinc finger proteins
            implicated in transcriptional repression mediated by chicken
            ovalbumin upstream promoter transcription factor (COUP-TF) orphan
            nuclear receptors
  JOURNAL   J Biol Chem 275 (14), 10315-10322 (2000)
   PUBMED   10744719
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_223693.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47681.1, DY315645.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000014.1  102231680-102231976
            298-627             JAXUCZ010000014.1  102238870-102239199
            628-729             JAXUCZ010000014.1  102310193-102310294
            730-2750            JAXUCZ010000014.1  102315159-102317179
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2750
                     /gene="Bcl11a"
                     /note="BCL11 transcription factor A"
                     /db_xref="GeneID:305589"
                     /db_xref="RGD:1309923"
     exon            1..297
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    183..185
                     /gene="Bcl11a"
                     /note="upstream in-frame stop codon"
     CDS             243..2750
                     /gene="Bcl11a"
                     /note="B-cell CLL/lymphoma 11A (zinc finger protein);
                     BCL11A, BAF complex component; BAF chromatin remodeling
                     complex subunit BCL11A"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 11A"
                     /protein_id="NP_001178612.1"
                     /db_xref="GeneID:305589"
                     /db_xref="RGD:1309923"
                     /translation="MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHD
                     LLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVG
                     IQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQ
                     GICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLG
                     AECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDP
                     HRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPG
                     RPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNL
                     VVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEP
                     GTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTES
                     ERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVL
                     GEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLG
                     SPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQS
                     PFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRR
                     SDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKD
                     VYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE"
     misc_feature    1374..1439
                     /gene="Bcl11a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1374..1439
                     /gene="Bcl11a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1377..1439
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1377..1439
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1413..1490
                     /gene="Bcl11a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1413..1490
                     /gene="Bcl11a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1461..1523
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1461..1523
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2469..2534
                     /gene="Bcl11a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    2469..2534
                     /gene="Bcl11a"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    2472..2534
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2472..2534
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2487..2489,2493..2495,2499..2501,2505..2510,
                     2517..2522,2529..2531,2571..2573,2577..2579,2589..2594,
                     2601..2606,2613..2615,2661..2663,2667..2669,2673..2675,
                     2679..2684,2691..2696)
                     /gene="Bcl11a"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2487..2489,2493..2495,2499..2501,2505..2510,
                     2517..2522,2529..2531,2571..2573,2577..2579,2589..2594,
                     2601..2606,2613..2615,2661..2663,2667..2669,2673..2675,
                     2679..2684,2691..2696)
                     /gene="Bcl11a"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2508..2585
                     /gene="Bcl11a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2508..2585
                     /gene="Bcl11a"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2556..2618
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2556..2618
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2646..2702
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2646..2702
                     /gene="Bcl11a"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            298..627
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     exon            628..729
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     exon            730..2750
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctcttcc tctctctctc tttttttttt cttaaaaaaa aaaaaaagcc atgacggctc
       61 tcccacaatt catcttccct gcgccatctt tgtattattt ctaatttatt ttggatgtca
      121 aaaggcactg atgaagatat tttctctgga gtctccttct ttctaacccg gctctcccga
      181 tgtgaaccga gccgtcgtcc gcacgccgcc gccgccgccg cccgcccgcc ccgcagccca
      241 ccatgtctcg ccgcaagcaa ggcaaacccc agcacttaag caaacgggaa ttctcgcccg
      301 aacctctcga agccattctt acagatgatg aaccagacca cggcccattg ggagctccag
      361 aaggggacca tgaccttctc acctgtgggc agtgccagat gaatttccca ttgggggaca
      421 ttcttatttt tatcgagcac aaacggaaac aatgcaatgg cagcctctgc ttagaaaaag
      481 gtgtggataa gccgccttcc ccttctccca tcgagatgaa aaaggcgtcc aatcccgtgg
      541 aggttggcat ccaggtgaca ccagaagatg acgattgttt atcaacgtca tctagaggaa
      601 tttgccccaa acaggaacac atagcagata aacttctgca ctggaggggc ctgtcctctc
      661 ctcggtctgc acacggagcc ctaatcccca cgcccgggat gagtgcagaa tatgccccgc
      721 agggtatttg taaagatgag cccagcagct acacatgtac aacttgcaaa cagccattca
      781 ccagtgcatg gtttctcttg caacacgcac agaacactca tggattaaga atctacttag
      841 aaagcgaaca cggaagcccc ctgaccccgc gggttggtat cccttcagga ctaggtgcag
      901 aatgtccttc ccagccatct ctccatggga ttcctattgc agacaataac ccctttaacc
      961 tgctaagaat accaggatca gtatccagag aggcttccgg cctggcagaa gggcgctttc
     1021 cacccactcc ccccctgttt agtccaccac cgagacatca cttggacccc caccgcatag
     1081 agcgcctggg ggcggaagag atggccctgg ccacccatca cccgagtgcc tttgacaggg
     1141 tgctgcggtt gaatccaatg gctatggagc ctccggccat ggatttctct aggagactta
     1201 gagagctggc agggaacacg tctagtccac cgctgtcccc aggccggccc agccctatgc
     1261 aaaggttact gcaaccattc cagccaggta gcaagccacc cttcctggcg acgccccccc
     1321 tccctcctct gcaatccgcc cctcctccct cccagccccc ggtcaagtcc aagtcatgcg
     1381 agttctgcgg caagacgttc aaatttcaga gcaacttggt ggtgcaccgg cgcagccata
     1441 ctggtgagaa gccctacaag tgcaacctgt gcgatcacgc gtgcacgcag gccagcaagc
     1501 tgaagcgtca catgaagaca cacatgcaca agtcgtcccc catgacagtt aagtccgacg
     1561 acggcctctc cacagccagc tccccggaac ctggcaccag cgacctggta ggcagcgcca
     1621 gcagtgcgct caagtcagtg gtggccaagt tcaagagtga gaacgacccc aacttgatcc
     1681 cggagaacgg ggatgaggag gaagaggagg acgacgagga agaagaggaa gaggaggaag
     1741 aggaggagga ggagctgacg gagagcgaga gggtggacta cggcttcggg ctgagcctgg
     1801 aggctgcgcg ccaccacgag aacagctctc ggggcgcagt ggtgggcgtg ggcgacgagg
     1861 gccgcgccct gcccgatgtc atgcagggca tggtgctcag ctccatgcag cacttcagcg
     1921 aggccttcca ccaggtcctg ggcgagaagc ataagcgcag ccacctggcc gaggccgagg
     1981 gccataggga cacttgcgac gaagactcgg tggccggcga gtcggaccgc atagacgatg
     2041 gcactgttaa tggtcgtggc tgctcccctg gcgaatcggc ttcggggggt ctgtccaaaa
     2101 agctcctgct gggtagcccc agctcgctga gccccttctc caagcgcatc aagctggaga
     2161 aggagtttga cctgcccccg gctgcgatgc ctaacacgga gaacgtgtac tcgcagtggc
     2221 tcgctggcta tgcagcctcc aggcagctca aagatccctt ccttaccttc ggagactcca
     2281 gacaatcgcc ttttgcctcc tcgtcagagc actcctcgga gaacgggagc ttgcgcttct
     2341 ccacgccgcc cggggagctg gacggaggga tctcggggcg cagcggcacg ggaagtggag
     2401 ggagcacgcc ccatattagt ggtccgggcc cgggcaggcc cagctcaaaa gagggcagac
     2461 gcagcgacac ttgtgagtac tgtgggaaag tcttcaagaa ctgtagcaat ctcactgtcc
     2521 acaggagaag ccacacgggc gaaaggcctt ataaatgcga gctgtgcaac tatgcctgtg
     2581 cccagagtag caagctcacc aggcacatga aaacgcatgg ccaggtgggg aaggacgttt
     2641 acaaatgtga aatttgtaag atgcctttta gcgtgtacag taccctggag aaacacatga
     2701 aaaaatggca cagtgaccga gtgttgaata atgatataaa aactgaatag
//
LOCUS       NM_001099506            2475 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 47 (Vom2r47), mRNA.
ACCESSION   NM_001099506 XM_001059944 XM_345218
VERSION     NM_001099506.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Martini,S., Silvotti,L., Shirazi,A., Ryba,N.J. and Tirindelli,R.
  TITLE     Co-expression of putative pheromone receptors in the sensory
            neurons of the vomeronasal organ
  JOURNAL   J Neurosci 21 (3), 843-848 (2001)
   PUBMED   11157070
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000002.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XM_345218.2, XM_001059944.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000002.1  151294837-151295112 c
            277-1137            JAXUCZ010000002.1  151291362-151292222 c
            1138-1368           JAXUCZ010000002.1  151284333-151284563 c
            1369-1492           JAXUCZ010000002.1  151266249-151266372 c
            1493-2475           JAXUCZ010000002.1  151265012-151265994 c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2475
                     /gene="Vom2r47"
                     /note="vomeronasal 2 receptor, 47"
                     /db_xref="GeneID:365807"
                     /db_xref="RGD:1559813"
     exon            1..276
                     /gene="Vom2r47"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2475
                     /gene="Vom2r47"
                     /note="vomeronasal receptor V2R2a"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 47"
                     /protein_id="NP_001092976.1"
                     /db_xref="GeneID:365807"
                     /db_xref="RGD:1559813"
                     /translation="MKTMIHTIKEINERKDILPNHTLGYQIFDTCFSISKTVESTFVF
                     LTGQEEYKPNFRNSSGKYLAGIIGSGGSSLSVASSRILEVYYMSQVGYTSSSSILSDH
                     FRFPTFYRTIPSDKIQTEAMVNLIKHFGWVWVGAIAADDDYGKYGIKSFKEKLERSNL
                     CVAFSETIPKVYSNEKMQKAINAVKSSTAKVVVLYATDIDLRPFVLEVVHHNITDRTW
                     IASEAWITSALIAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKDPNDVLTIEF
                     WQTAFNCTWPNSSVPYNVDYRGNMTGKEDRFYAMSDRLCTGEEKLEDLKNTYLDTSQL
                     RITNNVKQAVYLLAHALDRLSRCDVPQPDVKCSQIPNFDPFELMIYIMRMEFTTHDGR
                     KIELDRSGDVKNGYYDILNWQMDDAGEIAFVKFGEYKFTSSKYELVLSKNSTLFWNTE
                     SSELPDSFCTKLCPPGTRKGIRQGKPTCCFDCIPCADGYVSEKPGQRECDPCSEDDWS
                     NAEKSKCVPKLVEFLSYEEALGFTLVILSIFGALVVMAVTVVYVIHRHTPLVKANDRE
                     LSFFIQMSLVITVLSSMLFIGKPCNWSCMARQVTLALGFCLCLSSILGKTISLFFAYR
                     ISKSKTRLISMHPIFRKLIVLICVVGEIGVCTAYLVLEPPRMFKNIEPQNVKIIFECN
                     EGSIEFLYSIFGFNVLLALLCFLTTFVARQLPDNYYEGKCITFGMLVFFIVWISFVPA
                     YLSTKGKFKVAVEIFAILASSYGLLGCVFLPKCFIILLRPKRNTDETVGGRVPTLDKS
                     IQLTSASVSSELNNTAESIVLDE"
     misc_feature    10..1350
                     /gene="Vom2r47"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    10..1350
                     /gene="Vom2r47"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1372..1533
                     /gene="Vom2r47"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1372..1533
                     /gene="Vom2r47"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1591..2349
                     /gene="Vom2r47"
                     /note="vomeronasal type-2 receptor-like proteins, member
                     of the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R-like; cd15280"
                     /db_xref="CDD:320407"
     misc_feature    1591..2349
                     /gene="Vom2r47"
                     /note="vomeronasal type-2 receptor-like proteins, member
                     of the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R-like; cd15280"
                     /db_xref="CDD:320407"
     misc_feature    1591..1668
                     /gene="Vom2r47"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320407"
     misc_feature    1591..1668
                     /gene="Vom2r47"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320407"
     misc_feature    order(1600..1602,1609..1614,1621..1626,1630..1635,
                     1735..1737,1747..1749,1756..1761,1783..1785,1795..1797)
                     /gene="Vom2r47"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320407"
     misc_feature    order(1600..1602,1609..1614,1621..1626,1630..1635,
                     1735..1737,1747..1749,1756..1761,1783..1785,1795..1797)
                     /gene="Vom2r47"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320407"
     misc_feature    1702..1767
                     /gene="Vom2r47"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320407"
     misc_feature    1702..1767
                     /gene="Vom2r47"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320407"
     misc_feature    order(1762..1764,1798..1803,1810..1815,1822..1824,
                     2059..2061,2074..2076,2083..2088,2095..2097,2197..2199,
                     2206..2211,2218..2220,2230..2232,2254..2259,2266..2268,
                     2275..2277,2287..2289)
                     /gene="Vom2r47"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320407"
     misc_feature    order(1762..1764,1798..1803,1810..1815,1822..1824,
                     2059..2061,2074..2076,2083..2088,2095..2097,2197..2199,
                     2206..2211,2218..2220,2230..2232,2254..2259,2266..2268,
                     2275..2277,2287..2289)
                     /gene="Vom2r47"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320407"
     misc_feature    1792..1866
                     /gene="Vom2r47"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320407"
     misc_feature    1792..1866
                     /gene="Vom2r47"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320407"
     misc_feature    1933..1983
                     /gene="Vom2r47"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320407"
     misc_feature    1933..1983
                     /gene="Vom2r47"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320407"
     misc_feature    2062..2142
                     /gene="Vom2r47"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320407"
     misc_feature    2062..2142
                     /gene="Vom2r47"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320407"
     misc_feature    2164..2235
                     /gene="Vom2r47"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320407"
     misc_feature    2164..2235
                     /gene="Vom2r47"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320407"
     misc_feature    2248..2325
                     /gene="Vom2r47"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320407"
     misc_feature    2248..2325
                     /gene="Vom2r47"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320407"
     exon            277..1137
                     /gene="Vom2r47"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1368
                     /gene="Vom2r47"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1492
                     /gene="Vom2r47"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2475
                     /gene="Vom2r47"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgctgga tgaaaaccat gattcacacc atcaaggaga ttaatgagag gaaggacatt
       61 ttgcccaacc acactctggg ctaccagatt tttgacacct gtttctccat ctcgaaaaca
      121 gtggagtcaa ctttcgtgtt tcttacagga caggaagaat ataaacccaa ttttagaaac
      181 agctctggaa aatatctagc aggaattatt ggatcagggg gatcatcttt gtcagttgct
      241 tcttcaagaa ttctggaggt gtattacatg agtcaggtgg gctatacttc ttcctcctca
      301 attcttagtg accatttccg gtttccaact ttttatcgca caatacccag tgataaaatc
      361 cagactgagg ccatggtgaa tcttatcaaa cactttggtt gggtctgggt aggtgctatt
      421 gcagctgatg atgattatgg aaaatatgga ataaaatcct ttaaggaaaa actggagagg
      481 tccaacctct gcgttgcttt ctctgaaacc attccaaaag tctactccaa tgagaaaatg
      541 caaaaagcta ttaatgcagt aaagagttcc actgcaaaag tcgttgtgct ttatgcaact
      601 gacattgacc tcagaccctt tgtgctggaa gtggttcatc ataacataac cgacaggaca
      661 tggatagcca gtgaagcctg gattacctca gctctcattg caaagcctga gtattttccc
      721 tatttcggtg gaaccattgg atttgcaatc ccgagaagtg ttatacctgg attaaaagaa
      781 tttctttatg atgtacaccc tagcaaggat ccaaatgatg tcttgaccat tgaattctgg
      841 caaactgctt ttaactgtac ctggcccaac agtagtgtgc cttacaatgt ggactacaga
      901 gggaatatga ctggtaaaga agacagattt tatgccatgt ctgatcggct atgcactgga
      961 gaggagaagc tggaggatct gaaaaatact tatctggata catcccagct aagaatcaca
     1021 aacaatgtta aacaagccgt gtatcttttg gctcatgccc tggatcgttt aagcagatgt
     1081 gatgtaccgc aaccagatgt aaaatgctca caaataccta actttgaccc cttcgaacta
     1141 atgatttata ttatgagaat ggaatttact acccatgatg gacgcaaaat agaacttgat
     1201 agaagtggag acgtgaaaaa tggatattat gatattctca attggcaaat ggatgatgct
     1261 ggagaaattg cctttgtcaa gtttggagaa tacaaattca caagttctaa atatgaactt
     1321 gtcctttcaa agaactcaac attattctgg aacactgaat cttcagagct tccagattca
     1381 ttctgtacca aattatgtcc tccagggaca cggaagggga ttcgccaggg gaaacccaca
     1441 tgttgctttg attgcatccc atgtgctgat ggatatgtgt cagagaaacc aggccaaagg
     1501 gaatgtgatc catgcagtga agatgactgg tccaatgcag agaagagcaa gtgtgtacca
     1561 aagcttgtgg aatttctctc ttatgaggag gccctggggt tcaccctcgt catcctttcc
     1621 atatttgggg cacttgtggt catggcagta accgttgtgt atgtaatcca cagacacact
     1681 ccattggtga aagccaatga ccgggagctg agcttcttca ttcagatgtc tctggttatc
     1741 acagtgctgt catctatgct gttcataggc aaaccatgca actggtcctg catggcccgc
     1801 caggtcactc tggcattggg cttttgcctt tgtctgtctt ccattcttgg aaagactatt
     1861 tcactgtttt ttgcctacag gatttccaaa tctaaaaccc ggcttatatc catgcatcct
     1921 atttttcgta agctcattgt gttaatctgt gttgtagggg agattggtgt atgcacagct
     1981 tacttggtgt tggagcctcc aaggatgttc aagaacattg aacctcagaa tgtaaagatc
     2041 atctttgaat gcaatgaagg ttctatagag tttctttact ctatatttgg gtttaatgtc
     2101 cttctggctc tgctgtgttt tctcacaacc tttgtggctc gccagctgcc agataactat
     2161 tacgaaggga aatgtatcac ttttgggatg ctggtctttt tcattgtttg gatctctttt
     2221 gtccctgctt acttgagcac caaaggcaaa ttcaaagtgg ctgtggaaat atttgccatt
     2281 ttggcatcca gctatggctt gttgggctgt gtatttcttc ccaagtgttt cattattttg
     2341 ctgaggccaa agaggaacac ggatgaaact gttggtggaa gagtcccaac tcttgacaag
     2401 agcatccagt tgacctcagc ttctgtgagt agtgagctta acaacaccgc agagtcgatt
     2461 gttctggatg agtag
//
LOCUS       NM_001099509            2568 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 62 (Vom2r62), mRNA.
ACCESSION   NM_001099509 XM_001059771
VERSION     NM_001099509.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Aug 15, 2007 this sequence version replaced XM_001059771.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000012.1  22655664-22655863   c
            201-492             JAXUCZ010000012.1  22648911-22649202   c
            493-1299            JAXUCZ010000012.1  22647320-22648126   c
            1300-1530           JAXUCZ010000012.1  22646056-22646286   c
            1531-1660           JAXUCZ010000012.1  22645502-22645631   c
            1661-2568           JAXUCZ010000012.1  22638299-22639206   c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2568
                     /gene="Vom2r62"
                     /note="vomeronasal 2 receptor, 62"
                     /db_xref="GeneID:501816"
                     /db_xref="RGD:1598200"
     CDS             1..2568
                     /gene="Vom2r62"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 62"
                     /protein_id="NP_001092979.1"
                     /db_xref="GeneID:501816"
                     /db_xref="RGD:1598200"
                     /translation="MPTWIFFFFTLMLPMLLCKLLTHKCFVSSTDSVYQDGDLVISAF
                     LPLYTYQTSQHTEGAESIDVSSRITPYNYQYAMALIFAIEEINRNPILLPNVTLGYNI
                     HNAGSIESETVLSFLKWLTGQDIFIPNYTCKTKEKSVAAITGKTWEISSLIALFLGLY
                     KYPQLSIGPFEPSMNNSEKFPFLYQMAAKESSLALGMVSLFVHFRWNWVGLVISEDEN
                     GVNFVTDLIPQMERNTVCVAFMEFIPVTHMMDLDNAYEYHIRIMRYPAKVVIVYANTD
                     SSLGVLFRRWEYILPWRIWVTTSQWEVITSMRHLILDSFHGTLIFSQRQGDISTFKEF
                     VKTVRPSKYPDDIFLARLWEIYFDCAISNATCKSLKNCSSRGNLGLLPWYHFDIAVST
                     SSYHVYNAVYAVAHTMHKMLTQKGDLQGMKNGGSMDFPPLKLSSLLKNIKFMNPGGDP
                     ISLNPSEKLHIDYDILNFWDFPQGLTYKVKIGTFSPYFPPGQQLSISEDRIEWSIGLE
                     QQSPVSVCSESCVPGFRKSLQEGKAACCFDCVPCPENEISNGTGKYIDQCVKCTEDQY
                     ANTDRTVCIQKAVTFLALESPLGMTLASMALCFSILSSFVLGIFVKHQNTPVVKANNS
                     TLSYILLISLTFCFLCSFLFIGQPNAVTCILQQTTFGVVFTVAVSTVLAKTITVILAF
                     KSTAPGRRLRRLLISGAPKFIIPICTLIQTVLCGIWLGISPPFVDTNAHSEHGHIIIM
                     CNKGSVIAFYCVLGYLGVLSLVSFTVAFMARNLPDTFNEAKFLTFSMLVFLSVWITFL
                     PVYHSTKGKIMVAVEVFSILASSTGLLGCIFIPKCYIILARPDMNSSKCQRNRVQWK"
     misc_feature    118..1509
                     /gene="Vom2r62"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1509
                     /gene="Vom2r62"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r62"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r62"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r62"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r62"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1701
                     /gene="Vom2r62"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1701
                     /gene="Vom2r62"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1759..2511
                     /gene="Vom2r62"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1759..2511
                     /gene="Vom2r62"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1759..1836
                     /gene="Vom2r62"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1759..1836
                     /gene="Vom2r62"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1768..1770,1777..1782,1789..1794,1798..1803,
                     1903..1905,1915..1917,1924..1929,1951..1953,1963..1965)
                     /gene="Vom2r62"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1768..1770,1777..1782,1789..1794,1798..1803,
                     1903..1905,1915..1917,1924..1929,1951..1953,1963..1965)
                     /gene="Vom2r62"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1870..1935
                     /gene="Vom2r62"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1870..1935
                     /gene="Vom2r62"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1930..1932,1966..1971,1978..1983,1990..1992,
                     2230..2232,2245..2247,2254..2259,2266..2268,2368..2370,
                     2377..2382,2389..2391,2401..2403,2425..2430,2437..2439,
                     2446..2448,2458..2460)
                     /gene="Vom2r62"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1930..1932,1966..1971,1978..1983,1990..1992,
                     2230..2232,2245..2247,2254..2259,2266..2268,2368..2370,
                     2377..2382,2389..2391,2401..2403,2425..2430,2437..2439,
                     2446..2448,2458..2460)
                     /gene="Vom2r62"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1960..2034
                     /gene="Vom2r62"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1960..2034
                     /gene="Vom2r62"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2104..2154
                     /gene="Vom2r62"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2104..2154
                     /gene="Vom2r62"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2233..2313
                     /gene="Vom2r62"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2233..2313
                     /gene="Vom2r62"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2335..2406
                     /gene="Vom2r62"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2335..2406
                     /gene="Vom2r62"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2419..2496
                     /gene="Vom2r62"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2419..2496
                     /gene="Vom2r62"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..200
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
     exon            201..492
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1299
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1530
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1660
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..2568
                     /gene="Vom2r62"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccactt ggattttttt cttttttacc ctcatgcttc ctatgctcct gtgcaaattg
       61 ctcacccata agtgttttgt ttcttccaca gacagtgtat accaggatgg ggatttggtg
      121 atcagtgcgt tcttacccct ttatacctat caaacctccc aacacactga aggggcagag
      181 agtatagacg tcagttcacg gatcacgcca tacaactacc aatatgcgat ggccttaatt
      241 tttgccatag aggagataaa cagaaacccc attcttttac ctaacgtgac gcttggatat
      301 aatattcaca atgctgggtc cattgaaagt gagacagtat taagtttcct caaatggctc
      361 acagggcagg acatattcat cccgaactat acatgcaaaa ccaaggaaaa atcagtggct
      421 gcaatcacag gaaaaacatg ggaaatttct tccctaattg ccctattttt gggtctttat
      481 aaatatccac agctgagcat tggacctttt gaaccaagta tgaacaactc tgagaagttt
      541 ccctttttgt atcagatggc tgccaaagaa tcttctttgg ccttaggcat ggtctcattg
      601 tttgtccatt tcagatggaa ttgggtgggg ctggtcatct cagaggatga gaatggtgtt
      661 aactttgtca cagacttgat tccacaaatg gaaagaaaca cagtctgtgt agccttcatg
      721 gaatttatcc cagttactca catgatggac ctggataacg cttatgaata ccatattcgg
      781 attatgagat acccagccaa agttgttatc gtttacgcta acactgactc ttccttaggt
      841 gtgttgttta gaagatggga atatatactt ccatggagaa tctgggtgac cacttcacag
      901 tgggaagtca tcacttctat gagacattta attcttgact cattccatgg gactctcatc
      961 ttttcacaac gccagggtga tatttctact tttaaagagt ttgtaaagac agtgagacct
     1021 tctaaatacc cagatgacat ttttcttgcc agactgtggg agatttactt tgattgtgca
     1081 atatctaatg ctacctgtaa atcattaaaa aattgttcat ctagaggtaa cttgggattg
     1141 ttaccttggt accactttga catagctgta agtactagca gttaccatgt atacaatgct
     1201 gtatatgctg tggcccacac catgcacaag atgcttacac aaaaaggaga cctacaagga
     1261 atgaaaaacg gaggcagcat ggattttccc cccttgaagc tgagctccct gctgaagaac
     1321 attaaattca tgaatcctgg tggagatcca atatctttga atccttcaga gaaattgcac
     1381 atagattatg acattctgaa cttctgggat tttccacaag gtcttacata taaagtgaaa
     1441 ataggaacat tttctccata ttttccacct ggtcaacaat tgtcgatttc tgaggacagg
     1501 atagagtgga gtataggatt ggagcaacag agtcctgtct ctgtatgcag tgaaagttgt
     1561 gttcctggat tcagaaaatc tcttcaggaa gggaaagccg cttgctgttt tgattgtgtc
     1621 ccatgtccag aaaatgaaat ttccaatgga acaggcaagt atattgatca gtgtgtgaaa
     1681 tgtacagagg accagtatgc caacacagat cggactgtct gcatccaaaa agctgtgaca
     1741 tttctggctt tggaaagccc cttggggatg acactcgcca gcatggccct atgcttttct
     1801 atcctctcct catttgtcct ggggattttt gtaaagcacc aaaacactcc tgtggtgaag
     1861 gcaaataaca gtactctcag ctacatcttg ctcatctccc tcaccttctg ctttctttgc
     1921 tcatttctat tcattggtca gcccaacgca gtcacctgca tcctgcagca gaccacattt
     1981 ggagttgttt tcacagtggc tgtttctact gtcttggcaa aaaccattac agtcatcctg
     2041 gccttcaaga gcacagctcc aggaagaagg ttgaggaggc tgcttatatc aggagcaccg
     2101 aaattcatca ttcccatctg tacactaata caaactgtcc tctgtggaat ctggctggga
     2161 atatctcctc catttgtgga cacaaatgca cactctgaac atggtcatat cattattatg
     2221 tgcaacaagg gctcagtaat agccttctac tgtgttctgg gataccttgg agttctgtcc
     2281 ctagtgagct tcacagtagc ttttatggcc aggaacctgc ctgacacctt caatgaagcc
     2341 aagttcttga cgtttagcat gctggtgttc ctcagtgttt ggatcacatt tctccctgtc
     2401 taccacagta ctaaagggaa gatcatggtg gctgtggaag tcttctccat cttggcctcc
     2461 agcacaggtc ttctaggttg tatctttatc cccaaatgtt atattattct tgcaagacct
     2521 gacatgaact catcgaaatg ccaacgaaat agagttcagt ggaaataa
//
LOCUS       NM_001114603            2548 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus protocadherin beta 10 (Pcdhb10), mRNA.
ACCESSION   NM_001114603 NM_001014778 XM_001064875 XM_226045
VERSION     NM_001114603.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Wu,Q.
  TITLE     Comparative genomics and diversifying selection of the clustered
            vertebrate protocadherin genes
  JOURNAL   Genetics 169 (4), 2179-2188 (2005)
   PUBMED   15744052
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Feb 15, 2008 this sequence version replaced
            NM_001014778.1, XM_001064875.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643289.41242.1,
                                        SRR26643295.56088.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2548              JAXUCZ010000018.1  29391860-29394407
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2548
                     /gene="Pcdhb10"
                     /note="protocadherin beta 10"
                     /db_xref="GeneID:291649"
                     /db_xref="RGD:1308364"
     exon            1..2548
                     /gene="Pcdhb10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Pcdhb10"
                     /note="upstream in-frame stop codon"
     CDS             167..2548
                     /gene="Pcdhb10"
                     /note="protocadherin beta-5"
                     /codon_start=1
                     /product="protocadherin beta-5 precursor"
                     /protein_id="NP_001108075.1"
                     /db_xref="GeneID:291649"
                     /db_xref="RGD:1308364"
                     /translation="METASEKRQVVFLTILLLLWKSDAETIRYSMPEETESGYLVANL
                     AKDLGLRVGELATRGARIHHKGNKDLLQLDAETGNLILKEKPDREVLCRATEPCVLHF
                     QIILENPVQFFQTELQLTDINDHAPEFPDRKMLLKISESAQPGTMFPLKAAQDPDIGS
                     NAVQNYTVSPNLHFHVITHSRTDGRKYPELVLDRALDREEQPELTLTLIALDGGAPSR
                     SGTTTVHIEVVDINDNPPKFDQSLYEVQIPENSPLNALVATVSARDLDAGIHGTVIYS
                     LFQGGELSQPFEIDEVAGEIRLKGTLDFEATPYYNIEIVATDPGGFSGKCSVAIQVVD
                     VNDNAPKLTISSLNSSIPENAPEAVVAVFSVSDPDSGENGRIVCSIQNELPFLLKPTF
                     ENYYTLVTERPLDRESRADYNITITVSDLGIPRLTTQHTIIVQVSDINDNAPAFNQTS
                     YTLLVRENNSPALHIGTISATDSDTGANAHISYLLLPLYDMQLALTSLVSINQENGQL
                     FVLRALDYETLQTFEFSVGATDHGSPALSSQALVRVVVLDDNDNAPFVLYPLQNASVP
                     CTELLPRAAEPGYLVTKVVAVDCDSGQNAWLSFQLLKATEPGLFNVWAHNGEVRTTRL
                     LSERDVPKHKLLLVVKDNGEHQRSATVTLHVLLVDGFSQPYLPLPEVARDPVQDDEDV
                     LTLYLVIALASVSSLFLFSVLLFIGMRLCKRAREASLGVCSVPEGHFPGHLVDVSGTG
                     TLSQSYQYEVCLTGDSGTGEFKFLKPMISNLMVQDPGREVKESPPCRDSFVFS"
     sig_peptide     167..238
                     /gene="Pcdhb10"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    242..490
                     /gene="Pcdhb10"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    242..490
                     /gene="Pcdhb10"
                     /note="Cadherin-like; Region: Cadherin_2; pfam08266"
                     /db_xref="CDD:462413"
     misc_feature    572..868
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    572..868
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(584..589,755..757,761..763,854..856,860..865)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(584..589,755..757,761..763,854..856,860..865)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    893..1180
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    893..1180
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(911..916,1073..1075,1079..1081,1166..1168,
                     1172..1177)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(911..916,1073..1075,1079..1081,1166..1168,
                     1172..1177)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1214..1492
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1214..1492
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1223..1228,1379..1381,1385..1387,1478..1480,
                     1484..1489)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1223..1228,1379..1381,1385..1387,1478..1480,
                     1484..1489)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1514..1822
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1514..1822
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1535..1540,1709..1711,1715..1717,1808..1810,
                     1814..1819)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(1535..1540,1709..1711,1715..1717,1808..1810,
                     1814..1819)
                     /gene="Pcdhb10"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1877..2143
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1877..2143
                     /gene="Pcdhb10"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    2213..2461
                     /gene="Pcdhb10"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
     misc_feature    2213..2461
                     /gene="Pcdhb10"
                     /note="Cadherin cytoplasmic C-terminal; Region:
                     Cadherin_C_2; pfam16492"
                     /db_xref="CDD:465139"
ORIGIN      
        1 agagcgctat ctactcccta gaagaaggat ttggggtgtg atctagggga gagaactctg
       61 cggacagtga ggcattaaag attaaattca aggatatttt accaaaaggt ttttgtggac
      121 tgaaactgac tagaagaagc accgccctct ggactaaatc tcaacaatgg agaccgcatc
      181 agagaaaagg caagtcgttt tccttactat attgttgcta ttgtggaagt ctgacgctga
      241 gacaattaga tattcaatgc cagaagaaac agagagtggt tacttagtgg ctaatttggc
      301 aaaagatctt ggactcaggg ttggagaact ggccactaga ggggcacgaa tccatcacaa
      361 aggaaacaaa gacctcttgc agctggatgc agagactggg aatttaatcc tgaaggaaaa
      421 accagatcgt gaggtgctgt gtagggcgac agaaccctgt gtgctgcact tccagatcat
      481 actggaaaat cctgtacagt tctttcaaac tgaattgcag ctcacagata taaacgacca
      541 tgctccagag ttccccgaca gaaaaatgct tctaaaaatc tccgagagcg cccagccagg
      601 gaccatgttt cctctgaagg cagctcagga ccctgacata gggagcaatg ctgttcagaa
      661 ctacacagtg agtcccaacc tccatttcca cgtcattact cacagtcgca cagatggcag
      721 gaaataccca gagctggtgc tggacagagc cctggatagg gaggagcagc ctgaactcac
      781 tttaaccctc attgctctgg atggtggagc tccttccagg tcaggaacca ccacagttca
      841 cattgaagtt gtggacatca atgataaccc gcccaaattt gaccagtcgc tctatgaggt
      901 gcagattcct gaaaatagtc ccctcaacgc cttagtcgcc acggtttctg ccagagattt
      961 agatgctggg atacacggta ctgtaatcta ctctctgttt caaggtggtg aactatctca
     1021 accgtttgaa atagatgaag tcgcaggaga aattcgtctt aaagggacat tggattttga
     1081 ggcaactcca tattataaca tagaaatcgt agcgacagac ccaggaggct tttcaggaaa
     1141 atgcagtgtg gctatacagg tggtggatgt gaacgacaac gcccctaaac tcaccatatc
     1201 ttcactcaat agttccatcc cagaaaatgc tcctgaggct gtagttgctg tatttagtgt
     1261 ttctgaccca gattctgggg aaaatggaag gattgtttgt tctattcaga acgaacttcc
     1321 atttcttttg aagcccacat ttgagaacta ttatacttta gtaacagaga ggccacttga
     1381 tagagaaagc agagctgact acaacatcac catcactgtc tccgacctgg gcatacccag
     1441 gctcacaacc caacacacca taatagtgca ggtgtcggac attaatgaca acgctcctgc
     1501 cttcaaccaa acctcataca ccctgttggt ccgcgagaac aacagccccg ccctgcacat
     1561 aggcaccatc agcgccacag actccgacac tggcgctaat gcccatatca gctacttgct
     1621 actgccactc tatgatatgc agctggccct cacctctctg gtctccatca atcaagaaaa
     1681 tgggcagctg ttcgtgctca gggcactcga ctatgagacc ctgcagacct tcgagttcag
     1741 cgtgggtgcc acagaccatg gctcacccgc gctcagcagc caggctctgg tgcgggtggt
     1801 ggtgctggac gacaatgaca atgcgccctt cgtgctctac ccgctgcaga acgcctctgt
     1861 gccctgcacc gagctgctgc ccagagcggc agagccagga tacctggtca ccaaggtggt
     1921 agctgtggac tgcgactctg gccagaatgc ctggctgtca ttccagttgc tcaaggccac
     1981 agagcccggg ctgttcaacg tgtgggcgca caatggcgag gtacgcacca ccaggctact
     2041 gagcgagcgc gatgtgccca agcacaagct gctgctggtg gtcaaggaca atggcgagca
     2101 tcagcgctct gctacagtca cactgcacgt gctgctggtg gatggcttct cacagcccta
     2161 cctgcctttg ccagaggtgg cgcgggatcc cgtgcaagat gatgaggatg tgcttacact
     2221 gtacctggtc attgccttgg catctgtgtc ttcgctcttc ctcttctctg tcctgctctt
     2281 cattgggatg aggctgtgca agagggccag ggaggcttca ttgggcgtct gctctgtgcc
     2341 tgagggccac tttcctggcc acctggtgga tgttagcgga actgggactc tgtcccagag
     2401 ctaccagtat gaggtgtgtc tgactggaga ctctggaact ggtgagttca aattccttaa
     2461 acccatgatc tccaacttaa tggtccagga ccctgggaga gaagtgaagg aaagtccccc
     2521 ctgcagggat agctttgtat tcagttaa
//
LOCUS       NM_001191753            1420 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Ras association domain family member 8 (Rassf8),
            mRNA.
ACCESSION   NM_001191753 XM_232528
VERSION     NM_001191753.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_232528.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.25854.1,
                                           SRR26643429.18453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000004.1  180450747-180450828
            83-263              JAXUCZ010000004.1  180516426-180516606
            264-1153            JAXUCZ010000004.1  180522865-180523754
            1154-1298           JAXUCZ010000004.1  180524301-180524445
            1299-1420           JAXUCZ010000004.1  180524883-180525004
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1420
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="Ras association domain family member 8"
                     /db_xref="GeneID:312846"
                     /db_xref="RGD:1308820"
     exon            1..82
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /inference="alignment:Splign:2.1.0"
     exon            83..263
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="upstream in-frame stop codon"
     CDS             161..1420
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="Ras association (RalGDS/AF-6) domain family 8; Ras
                     association (RalGDS/AF-6) domain family (N-terminal)
                     member 8"
                     /codon_start=1
                     /product="ras association domain-containing protein 8"
                     /protein_id="NP_001178682.1"
                     /db_xref="GeneID:312846"
                     /db_xref="RGD:1308820"
                     /translation="MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIE
                     KWRDTERHLAPHENPIVSLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLY
                     RQSLPPLAKLRPQVDKSIRRREPKRKSLTFTGGAKGLTDIFGKGKETEFRQKVLSNCR
                     ATAEELTRLIRLQTGKLQAIEKQLESSEAEIRFWEQKYSCSLEEEIVRLEQRIKRNDV
                     EIEEEEFWENELQIEQENEKQLQDQLEEMRQKVADCEGRLKDYLAQIHTMESGLQAEK
                     LHREVQEAQVNEEEVKGKIEKVKGEVDLQGQQSLRLENGIRAVARSLGQATKRLQDKE
                     QELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPTEIEASQADIETEAPFPSGSLKRPG
                     SSRQLPSNLRILQNPVSSGFNPEGIYV"
     misc_feature    164..409
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="Ras-associating (RA) domain found in N-terminal
                     Ras-association domain family 8 (RASSF8); Region:
                     RA_RASSF8; cd16134"
                     /db_xref="CDD:340551"
     misc_feature    164..409
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="Ras-associating (RA) domain found in N-terminal
                     Ras-association domain family 8 (RASSF8); Region:
                     RA_RASSF8; cd16134"
                     /db_xref="CDD:340551"
     misc_feature    <617..>1192
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <617..>1192
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            264..1153
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1298
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1420
                     /gene="Rassf8"
                     /gene_synonym="RGD1308820"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacgtgtcc tggcagagtg tgatattcat caccagatgc catctgagcc cagtggagag
       61 gagcaacagg agccacctag agctgtgttt ctgaagccag agccatgacc tgacaccctg
      121 atgctactgt cagggcctct gtgcaactgg cacgtgcacc atggaactca aagtgtgggt
      181 ggatggagtc cagaggatcg tctgtggggt cacggaggtc acgacttgcc aggaggttgt
      241 aatagcctta gcccaagcca taggtcgaac tggaaggtac acccttatag agaaatggag
      301 agacactgaa cgtcacttgg caccacatga aaaccccatt gtgtccttga acaagtgggg
      361 gcagtatgct agtgatgtgc agctcatctt gcgtcggact gggccatctc tcagtgagcg
      421 acccacctca gacagtgtgg cccgcattcc cgaaagaact ttgtatcgac agagcctgcc
      481 ccctttagcc aagcttcggc ctcaggtaga caagtccatc agaaggagag agcctaaaag
      541 aaaatctctc accttcacag gaggggccaa agggctgacg gacatatttg gaaaaggtaa
      601 agagactgag tttaggcaga aggtgctgag taactgcagg gcaacagcag aggagctgac
      661 aaggctgatc cggctgcaga cggggaagct gcaggccatc gagaagcagc tggagtccag
      721 tgaggcagag attcgattct gggagcagaa gtacagctgt agtctggaag aagagattgt
      781 ccgcctagag caaaggatca agagaaatga cgtggagatc gaggaggaag agttctggga
      841 aaacgaatta cagatcgagc aggagaacga gaagcagctg caggatcagc tggaggagat
      901 gaggcagaaa gtagccgact gcgaaggcag gctaaaggac tacctggccc aaatccacac
      961 gatggagagt ggtctccagg cagaaaaact gcaccgggaa gttcaggagg cacaggtcaa
     1021 cgaggaggag gtgaaaggaa agatcgaaaa ggtcaagggg gaggtggacc ttcaaggaca
     1081 acagagccta cgcctggaga acggaattag agcggtggcg aggtctctgg ggcaggccac
     1141 caagaggtta caggacaagg agcaggagct ggagcagttg accaaagagc tgcggcaggt
     1201 caacctccag cagttcatcc agcagacagg gaccaaggtc actgtgctgc cggccgagcc
     1261 cactgaaatc gaggcctcgc aggcagacat agagacagag gcacctttcc cgtctgggtc
     1321 cctgaagcga cctggttcat cacggcagct ccccagtaac ctccgtatcc tgcagaaccc
     1381 tgtctcctcc ggttttaacc ctgaaggcat ctatgtatag
//
LOCUS       NM_001099507            2574 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 50 (Vom2r50), mRNA.
ACCESSION   NM_001099507 XM_001061646 XM_575663
VERSION     NM_001099507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Ryba,N.J. and Tirindelli,R.
  TITLE     A new multigene family of putative pheromone receptors
  JOURNAL   Neuron 19 (2), 371-379 (1997)
   PUBMED   9292726
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XM_575663.2, XM_001061646.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000004.1  158487009-158487232
            225-522             JAXUCZ010000004.1  158488271-158488568
            523-1332            JAXUCZ010000004.1  158498635-158499444
            1333-1557           JAXUCZ010000004.1  158501614-158501838
            1558-1681           JAXUCZ010000004.1  158503039-158503162
            1682-2574           JAXUCZ010000004.1  158508360-158509252
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2574
                     /gene="Vom2r50"
                     /note="vomeronasal 2 receptor, 50"
                     /db_xref="GeneID:500312"
                     /db_xref="RGD:1566165"
     CDS             1..2574
                     /gene="Vom2r50"
                     /note="putative pheromone receptor V2R1-1"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 50 precursor"
                     /protein_id="NP_001092977.1"
                     /db_xref="GeneID:500312"
                     /db_xref="RGD:1566165"
                     /translation="MKLLIVLIAFSLLIVLIVFQEQISCFSLTKPASPGYYQDGDFVI
                     GGIFSLRVTAGDTRSRFGFKDTIYIPEYVYVDLTKHYQHILAMVFAIEKINKDTNILF
                     NMSLGFYLFNVDFIDMKAVESSMALLSGQTPPVPNYSCRPEKTDKLVAVIGGISTGIS
                     TRISQVLSLYNVPQISYAPFDQSLGTGVQLQSPYQFPVYTTALYQGIIQLLLYFTWVW
                     VGLVVPDDVRGELFLRDITEEMNNHGLCVAFAEKVPEFPAKDTVDRELFMERFTLTHV
                     IVAFGDTYSLLRFVYNIFCNTPFGNVWITTSDWDITTLPFQQNLGYTYFGGGLSFSVH
                     MDEILGFKDFLRRVQPRKYPQDIFIQDVWSNLFECPYLDKDWIRELSQCEQNGNLSTR
                     PLHLWDMNTSPSSYKIHAAVYAIAQALHEELSLIVEGDLLNKGVPRAPLPWKLHPFLQ
                     NGQLGRSTNEETVVNKEVSATKLDIFNYQSLQSSTKAQVKVGEFVFESHSVQHFSLND
                     ELITWGEHHSQTPFAVCSQSCMLGFRKTPVEGKPFCCFDCLPCPDGEIANETDMDQCI
                     KCPEDQYPNKQRNQCLPKITAFLSHEDTLGAVFISLAISFSAFSAMILGLFICYRDTP
                     IVRANNRNLSYLLLVSLMLCFFCSLIFIGQPRTVTCVLRQTIFGVVFSIAISAILAKT
                     FIVVVAFKAIKPGSTLQTWMVTRVSNAIVCCGSSIQVCICAVWLGTYPPFPDVDMQSE
                     FGQIILWCNEGSTLAFYCVLGYLGFLASLSLLIAFLARRLPDTFNEAKTITFSMLVFC
                     SVWISFVPAYLSSKGKNVVAVEILAILASSAGLLGCIFLPKCFVILLRSDDLPRKKFF
                     K"
     sig_peptide     1..75
                     /gene="Vom2r50"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    127..1539
                     /gene="Vom2r50"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    127..1539
                     /gene="Vom2r50"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(235..237,532..537,1210..1212)
                     /gene="Vom2r50"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(235..237,532..537,1210..1212)
                     /gene="Vom2r50"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,493..495,754..756)
                     /gene="Vom2r50"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,493..495,754..756)
                     /gene="Vom2r50"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1561..1722
                     /gene="Vom2r50"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1561..1722
                     /gene="Vom2r50"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1780..2535
                     /gene="Vom2r50"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1780..2535
                     /gene="Vom2r50"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1780..1857
                     /gene="Vom2r50"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1780..1857
                     /gene="Vom2r50"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1789..1791,1798..1803,1810..1815,1819..1824,
                     1924..1926,1936..1938,1945..1950,1972..1974,1984..1986)
                     /gene="Vom2r50"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1789..1791,1798..1803,1810..1815,1819..1824,
                     1924..1926,1936..1938,1945..1950,1972..1974,1984..1986)
                     /gene="Vom2r50"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1891..1956
                     /gene="Vom2r50"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1891..1956
                     /gene="Vom2r50"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1951..1953,1987..1992,1999..2004,2011..2013,
                     2251..2253,2266..2268,2275..2280,2287..2289,2389..2391,
                     2398..2403,2410..2412,2422..2424,2446..2451,2458..2460,
                     2467..2469,2479..2481)
                     /gene="Vom2r50"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1951..1953,1987..1992,1999..2004,2011..2013,
                     2251..2253,2266..2268,2275..2280,2287..2289,2389..2391,
                     2398..2403,2410..2412,2422..2424,2446..2451,2458..2460,
                     2467..2469,2479..2481)
                     /gene="Vom2r50"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1981..2055
                     /gene="Vom2r50"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1981..2055
                     /gene="Vom2r50"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2125..2175
                     /gene="Vom2r50"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2125..2175
                     /gene="Vom2r50"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2254..2334
                     /gene="Vom2r50"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2254..2334
                     /gene="Vom2r50"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2356..2427
                     /gene="Vom2r50"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2356..2427
                     /gene="Vom2r50"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2440..2517
                     /gene="Vom2r50"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2440..2517
                     /gene="Vom2r50"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..224
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
     exon            225..522
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1332
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1557
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1681
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..2574
                     /gene="Vom2r50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaattac tcattgtact cattgctttc tctctcctga ttgttctcat tgtattccag
       61 gaacaaattt cttgtttctc cttaactaaa cctgcttctc ctggctacta tcaagatggg
      121 gattttgtta ttggaggaat cttttccctt agagtgactg ctggagacac aagaagtaga
      181 tttggcttta aagatacaat ctatatacca gaatatgttt atgtggatct caccaaacat
      241 tatcagcata ttttggcaat ggtttttgct atagaaaaaa tcaacaagga cacaaatatt
      301 ctattcaata tgtccctggg attctatctc ttcaatgttg attttattga tatgaaggcc
      361 gtggaaagtt ctatggcttt gctctcagga cagacccccc cagttcctaa ctacagctgc
      421 aggcctgaga agactgataa gctggttgca gtgataggag gcatttcaac aggaatatca
      481 accaggatct cccaagttct aagtctctac aatgtccctc agatcagcta tgctcctttt
      541 gaccagagtc ttgggaccgg agtccagctg cagtctccat accagtttcc tgtgtacacc
      601 acagctttgt atcagggaat aattcaactg ctgctatact tcacttgggt ctgggttggt
      661 ctggtggttc cagatgatgt gaggggagaa ctcttcctta gggacatcac agaggagatg
      721 aacaaccatg gactttgtgt tgcatttgca gaaaaagttc cagaatttcc tgctaaggac
      781 acagtagaca gggaactttt tatggaaaga ttcacattga cccatgttat tgttgcattt
      841 ggtgacacat attctcttct gagatttgtc tacaacatct tttgcaatac cccttttggt
      901 aatgtctgga tcacaacttc tgattgggat atcaccacat taccctttca acaaaatcta
      961 ggttatacat attttggtgg aggattatca ttttctgttc acatggatga aattctggga
     1021 ttcaaggatt ttctcagaag agtccaacct aggaaatacc ctcaagatat ctttatccag
     1081 gatgtgtggt cgaacttatt tgaatgtcct tatttagata aggactggat cagggaactg
     1141 agtcaatgtg agcaaaatgg caacctcagt acacgacctc tgcatctttg ggatatgaat
     1201 acctcacctt caagctacaa aatccatgct gctgtatatg ccattgccca ggcccttcat
     1261 gaggagctgt cactcattgt ggaaggagac ttattgaata aaggtgtacc ccgagctcct
     1321 ctcccatgga agctccatcc attcttacaa aatggccagc tagggagaag caccaatgag
     1381 gaaactgttg tgaacaagga agtttcagca accaagcttg acatctttaa ttaccagtct
     1441 ctgcagagca gtaccaaagc tcaagtgaaa gttggcgagt ttgtctttga gtctcacagt
     1501 gttcaacatt tttccctaaa tgacgaactc ataacgtggg gtgaacacca cagtcagact
     1561 ccatttgctg tttgcagtca aagttgcatg cttggattta ggaaaacacc tgttgaaggg
     1621 aaaccattct gttgttttga ttgtctccca tgtccagatg gagagattgc aaatgaaacg
     1681 gatatggatc aatgcatcaa atgtcctgaa gatcagtatc caaataagca gaggaatcag
     1741 tgtctcccta aaattacagc atttttgtcc catgaagata ctctgggagc tgttttcatc
     1801 tccttggcca ttagtttttc tgccttttca gctatgattt taggattatt tatctgctat
     1861 cgggacacac ccattgtcag agcaaataac agaaatctca gttatctcct cctggtttct
     1921 ctaatgctct gcttcttttg ctcattaata ttcattggcc aacctagaac agtcacttgt
     1981 gtcttgagac aaacaatttt tggggttgta ttttccattg ccatttctgc tatcttggca
     2041 aagaccttca ttgtggttgt ggccttcaag gccatcaaac ctggaagcac tttacaaaca
     2101 tggatggtga cccgagtctc aaatgctata gtctgctgtg gttccagcat tcaagtgtgc
     2161 atctgtgcag tctggctggg aacgtatccc cctttccctg atgtcgacat gcagtcagag
     2221 tttgggcaaa tcatcctctg gtgtaacgag ggctccaccc ttgccttcta ttgtgttctg
     2281 gggtacttgg gctttctggc cagtctcagt ttgcttattg cttttcttgc tagaaggcta
     2341 ccagacacct tcaatgaggc aaaaacaatc acattcagca tgctggtttt ctgcagtgtg
     2401 tggatttctt ttgtacccgc ttacctgagc tccaaaggca aaaacgttgt ggctgtggaa
     2461 attcttgcaa ttctggcttc cagtgctggc ttactgggct gtatatttct tcccaaatgc
     2521 tttgtgatcc tactgagatc agatgacctt ccaagaaaga agttctttaa atga
//
LOCUS       NM_001191894            1437 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus serine/threonine kinase 32A (Stk32a), mRNA.
ACCESSION   NM_001191894 XM_344677
VERSION     NM_001191894.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1437)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jul 17, 2010 this sequence version replaced XM_344677.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1124959.1,
                                           SRR26360172.1588172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000018.1  35509982-35510128
            148-295             JAXUCZ010000018.1  35514016-35514163
            296-351             JAXUCZ010000018.1  35542139-35542194
            352-503             JAXUCZ010000018.1  35543151-35543302
            504-677             JAXUCZ010000018.1  35565261-35565434
            678-715             JAXUCZ010000018.1  35592405-35592442
            716-805             JAXUCZ010000018.1  35600553-35600642
            806-903             JAXUCZ010000018.1  35609158-35609255
            904-1020            JAXUCZ010000018.1  35614724-35614840
            1021-1146           JAXUCZ010000018.1  35616207-35616332
            1147-1275           JAXUCZ010000018.1  35617737-35617865
            1276-1340           JAXUCZ010000018.1  35618478-35618542
            1341-1437           JAXUCZ010000018.1  35619285-35619381
FEATURES             Location/Qualifiers
     source          1..1437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1437
                     /gene="Stk32a"
                     /note="serine/threonine kinase 32A"
                     /db_xref="GeneID:364858"
                     /db_xref="RGD:1308338"
     exon            1..147
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            148..295
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    214..216
                     /gene="Stk32a"
                     /note="upstream in-frame stop codon"
     CDS             244..1437
                     /gene="Stk32a"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 32A"
                     /protein_id="NP_001178823.1"
                     /db_xref="GeneID:364858"
                     /db_xref="RGD:1308338"
                     /translation="MGANTSSKAPVLDENEDVNFDHFEILRAIGKGSFGKVCIVQKND
                     TKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL
                     LLGGDLRYHLQQNVHFQEDTVKLFICELAMALDYLQSQRIIHRDMKPDNILLDEHGHV
                     HITDFNIAAMLPKETRITTVAGTKPYMAPEMFSSRKESGYSFAVDWWSLGVTAYELLR
                     GRRPYHIRSSTSSKEIVNMFETAIVTYPSAWSAEMVSLLKKLLEPNPDQRFSHLTDIQ
                     NFPYMSDMNWDAVLQKRLIPGFVPTKGRLNCDPTFELEEMILESKPLHKKKKRLAKKE
                     KEMKKCDSPQMCLLQEHLDAVQKEFIIFNREKVKRDFNQRQANIALEQTKNNTEEEDG
                     QNNNL"
     misc_feature    307..1086
                     /gene="Stk32a"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Yank1; Region: STKc_Yank1; cd05578"
                     /db_xref="CDD:270730"
     misc_feature    307..1086
                     /gene="Stk32a"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Yank1; Region: STKc_Yank1; cd05578"
                     /db_xref="CDD:270730"
     misc_feature    order(328..342,352..354,391..393,397..399,493..495,
                     541..546,550..552,562..564,568..570,679..681,685..687,
                     691..696,700..702,730..735,742..744,781..798,886..888,
                     904..906,913..915)
                     /gene="Stk32a"
                     /note="active site"
                     /db_xref="CDD:270730"
     misc_feature    order(328..342,352..354,391..393,397..399,493..495,
                     541..546,550..552,562..564,568..570,679..681,685..687,
                     691..696,700..702,730..735,742..744,781..798,886..888,
                     904..906,913..915)
                     /gene="Stk32a"
                     /note="active site"
                     /db_xref="CDD:270730"
     misc_feature    order(328..342,352..354,391..393,397..399,493..495,
                     544..552,562..564,679..681,685..687,691..696,700..702,
                     730..735)
                     /gene="Stk32a"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270730"
     misc_feature    order(328..342,352..354,391..393,397..399,493..495,
                     544..552,562..564,679..681,685..687,691..696,700..702,
                     730..735)
                     /gene="Stk32a"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270730"
     misc_feature    order(340..342,562..564,568..570,679..681,685..687,
                     691..693,742..744,781..798,886..888,904..906,913..915)
                     /gene="Stk32a"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270730"
     misc_feature    order(340..342,562..564,568..570,679..681,685..687,
                     691..693,742..744,781..798,886..888,904..906,913..915)
                     /gene="Stk32a"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270730"
     misc_feature    order(730..762,772..798)
                     /gene="Stk32a"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270730"
     misc_feature    order(730..762,772..798)
                     /gene="Stk32a"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270730"
     exon            296..351
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            352..503
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            504..677
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            678..715
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            716..805
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            806..903
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1020
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1146
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1275
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1340
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1437
                     /gene="Stk32a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggcaggt gcctgagccc agcgagcagt cctgccaggg ccattccctc aaccgcgtcc
       61 tgatccgcag gtgtcttctg tatctgtctt tcctggcctg ctgagttctg tcagcctctg
      121 ctcctcgaat ggaaacatca tcctgaggta tccagccaat tttttggggc ctacattaaa
      181 caaagatgag tgcttcttcc aggatacttt aactagagtg tccaggtcag ttcaaacttg
      241 accatgggag ccaacacttc aagcaaagca ccagtgcttg atgaaaatga agacgtcaac
      301 tttgaccact ttgaaatttt gcgagccatt gggaagggca gttttgggaa ggtctgcatt
      361 gtgcagaaga atgataccaa gaagatgtac gccatgaagt acatgaataa acagaagtgt
      421 gtggagcgga atgaagtgag gaatgtcttc aaagaactcc agatcatgca gggcctagaa
      481 caccctttcc tggtgaatct gtggtattcc ttccaagatg aagaagacat gttcatggtg
      541 gtggacctgc tacttggtgg ggacctgcgt tatcacctgc agcagaatgt ccacttccag
      601 gaggacacag tgaagctctt catctgtgag ctggccatgg ccctggacta tctgcagagc
      661 cagcgcatca ttcacaggga tatgaaacca gacaatattt tacttgatga acatgggcat
      721 gtgcacatca cagacttcaa cattgctgcc atgctgccca aggagactag gatcaccacc
      781 gtagctggca ccaagcccta catggcaccc gagatgttca gctctaggaa ggaatcgggt
      841 tactccttcg ctgttgactg gtggtccctc ggggtgacgg cttatgaact gctgagaggc
      901 cggaggccat atcacatccg ctccagtact tccagcaagg aaattgtcaa catgtttgag
      961 acagcaattg taacttaccc ttctgcctgg tcagcagaga tggtatccct tcttaaaaag
     1021 ctgcttgaac ctaatccaga tcaacgcttt tctcacttga ctgacattca gaatttccct
     1081 tatatgagtg acatgaactg ggatgcagtc ctgcagaaga ggctcattcc aggcttcgtt
     1141 ccaactaaag gtaggcttaa ttgtgaccct acttttgaac tggaagaaat gattttggag
     1201 tccaaacctc ttcacaagaa aaagaagcgc ctggctaaaa aggagaagga aatgaagaaa
     1261 tgtgactccc ctcagatgtg ccttcttcaa gagcatcttg acgctgttca gaaggaattt
     1321 ataattttca acagagaaaa agtaaaaaga gactttaatc aaagacaagc aaatatagcc
     1381 ttggagcaaa ccaaaaacaa cacagaagag gaggatggcc agaataacaa cctataa
//
LOCUS       NM_001191734            2676 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus patched domain containing 1 (Ptchd1), mRNA.
ACCESSION   NM_001191734 XM_228985
VERSION     NM_001191734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Tora,D., Gomez,A.M., Michaud,J.F., Yam,P.T., Charron,F. and
            Scheiffele,P.
  TITLE     Cellular Functions of the Autism Risk Factor PTCHD1 in Mice
  JOURNAL   J Neurosci 37 (49), 11993-12005 (2017)
   PUBMED   29118110
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Wells,M.F., Wimmer,R.D., Schmitt,L.I., Feng,G. and Halassa,M.M.
  TITLE     Thalamic reticular impairment underlies attention deficit in
            Ptchd1(Y/-) mice
  JOURNAL   Nature 532 (7597), 58-63 (2016)
   PUBMED   27007844
REFERENCE   3  (bases 1 to 2676)
  AUTHORS   Noor,A., Whibley,A., Marshall,C.R., Gianakopoulos,P.J., Piton,A.,
            Carson,A.R., Orlic-Milacic,M., Lionel,A.C., Sato,D., Pinto,D.,
            Drmic,I., Noakes,C., Senman,L., Zhang,X., Mo,R., Gauthier,J.,
            Crosbie,J., Pagnamenta,A.T., Munson,J., Estes,A.M., Fiebig,A.,
            Franke,A., Schreiber,S., Stewart,A.F., Roberts,R., McPherson,R.,
            Guter,S.J., Cook,E.H. Jr., Dawson,G., Schellenberg,G.D.,
            Battaglia,A., Maestrini,E., Jeng,L., Hutchison,T.,
            Rajcan-Separovic,E., Chudley,A.E., Lewis,S.M., Liu,X., Holden,J.J.,
            Fernandez,B., Zwaigenbaum,L., Bryson,S.E., Roberts,W., Szatmari,P.,
            Gallagher,L., Stratton,M.R., Gecz,J., Brady,A.F., Schwartz,C.E.,
            Schachar,R.J., Monaco,A.P., Rouleau,G.A., Hui,C.C., Lucy
            Raymond,F., Scherer,S.W. and Vincent,J.B.
  CONSRTM   Autism Genome Project Consortium
  TITLE     Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum
            disorder and intellectual disability
  JOURNAL   Sci Transl Med 2 (49), 49ra68 (2010)
   PUBMED   20844286
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_228985.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.31932.1,
                                           SRR26360176.996656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000021.1  43496907-43497266
            361-1021            JAXUCZ010000021.1  43533291-43533951
            1022-2676           JAXUCZ010000021.1  43546759-43548413
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /note="patched domain containing 1"
                     /db_xref="GeneID:317517"
                     /db_xref="RGD:1564527"
     exon            1..360
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /codon_start=1
                     /product="patched domain-containing protein 1"
                     /protein_id="NP_001178663.1"
                     /db_xref="GeneID:317517"
                     /db_xref="RGD:1564527"
                     /translation="MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFS
                     RYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQ
                     KANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVHVLEEL
                     KNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSI
                     NSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSRVSERYLVTSL
                     ILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPF
                     VMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASP
                     FTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEVL
                     QEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFY
                     LIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEY
                     WNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKNFTDMLRNSFLKAPQFS
                     HFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREELYDLLETLRRLSVTSKVKFIVF
                     NPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIG
                     FMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAI
                     LQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKR
                     KEKKNPENREEIECVEMLDIDSTRVVDQITTV"
     misc_feature    322..2562
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /note="Patched family; Region: Patched; pfam02460"
                     /db_xref="CDD:308203"
     misc_feature    322..2562
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /note="Patched family; Region: Patched; pfam02460"
                     /db_xref="CDD:308203"
     exon            361..1021
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctctagga tgctgcggca ggttctgcac aggggcttga ggacgtgttt ctcccggctt
       61 ggccacttca ttgccagtca cccggtcttc ttcgcttcgg cgccggtgct catctccatc
      121 ctgctcggcg ccagcttcag ccgctaccag gtggaagaga gcgtggagca cctgctggcg
      181 ccccagcaca gcctagccaa gatcgagcgc aacctagtca acagcctatt cccggtcaac
      241 cgctccaagc accggctcta ctcggacctg cagacccctg ggcgctacgg ccgggtcatt
      301 gtcacctcct accagaaagc caacatgcta gaccagcatc acacggacct gatcttaaag
      361 ttgcacactg ctgtaaccaa gatccaggtt ccaaggcctg gctttaacta tacatttgcc
      421 cacatatgtg tcctgaataa tgataagact tgcattgtgg atgacatagt acacgtcctg
      481 gaagagctaa agaatgctcg ggccaccaat cggaccaatt ttgctatcac atatccgatc
      541 actcacttaa aggatggaag ggctgtctat aatgggcacc aacttggagg tgtcactgtg
      601 cacagcaagg atcgggtgaa atctgcggag gccattcagc tcacctacta tctgcaatca
      661 atcaacagtc tcaatgacat ggtagctgag aggtgggagt ccagcttctg cgacactgtc
      721 aaattattcc agaaatccaa cagcaaagtc aaaatatacc cgtacacatc ctcatcactg
      781 agggaagatt tccagaagac cagccgtgtg tcagaacgtt acctggtcac cagtctgatc
      841 cttgtagtca ccatggccat tctgtgctgc tctatgcagg actgtgtccg cagcaaaccc
      901 tggttaggcc tacttgggtt ggtgaccata agcctagcca ctctcactgc agctggaatc
      961 atcaatctta ctggtggaaa atacaattcc accttcctgg gagtcccttt cgtcatgcta
     1021 ggtcatggat tatacgggac ttttgaaatg ttatcctcgt ggagaaaaac tagagaggac
     1081 caacatgtta aagagcgaac tgcagaagtc tatgcagact ccatgctctc cttctctctc
     1141 accactgcca tgtacttggt cacctttggc ataggggcca gccctttcac gaacattgag
     1201 gcagccagga ttttctgctg caattcctgt attgcaatcc tcttcaacta cctctatgta
     1261 ctctcatttt acggttccag ccttgtgttc actggctaca tagaaaacaa ttaccagcat
     1321 agtatattct gtagaaaagt tccaaagcct gaggtattac aggagaagcc agcatggtat
     1381 aggtttcttc tgacagctag attcagtgag gacacagctg aaggtgagga agcaaacact
     1441 tatgagagtc atttattggt atgtttcctc aaacgttatt actgtgactg gataaccaac
     1501 acctatgtca agccttttgt agtcctcttt taccttattt atatttcctt tgccttaatg
     1561 ggctatctgc aggtcagtga agggtcagac cttagtaaca tcgtagcaac tgcaacacaa
     1621 accattgagt acactactgc ccaccaaaag tactttaaca actacagtcc tgttattggg
     1681 ttttacatat atgagtccat agaatattgg aactctagtg tccaagaaga tgttctagag
     1741 tacactaagg gttttgtgcg gatatcctgg tttgaaagct atttaaatta tcttcggaaa
     1801 ctcaatgtgt ccactgactt gcctaagaaa aatttcacag acatgttgag aaattccttc
     1861 ctgaaagctc ctcaattttc acattttcaa gaggacatca tcttctctaa aaaatacaat
     1921 gatgaggttg acgtagtggc ctctagaatg tttttggtgg ccaagactat ggaaacaaac
     1981 agagaagaac tttatgatct cttggagacc ctgaggaggc tttcagtcac ctccaaggtg
     2041 aagttcattg tctttaatcc gtcttttgtg tacatggatc gatatgcctc ctctctggga
     2101 gcccccctgc acaactcctg catcagtgct ttgttcctgc tcttcttctc ggcattcctg
     2161 gtagcagatt cgctgattaa tgtctggatc actctaacgg ttgtgtctgt ggagtttgga
     2221 gtgataggct tcatgacatt atggaaggtc gaactggatt gtatttctgt gctatgctta
     2281 atttatggaa ttaactacac aattgataac tgtgctccac tgttatccac atttgtccta
     2341 ggcaaggatt ttacaagaac taaatgggta aaaaatgccc tggaagtgca tggggtagct
     2401 attttacaga gttacctctg ttatattgtt ggtctatttc ctctcgcagc tgtgccttca
     2461 aatctgacct gtacactgtt caggtgcttg tttttaatag catttgtcac cttctttcac
     2521 tgctttgcca ttttacctgt gatactgact ttcctgccac cctctaagaa aaaaaggaaa
     2581 gagaagaaaa atcctgaaaa ccgggaggaa attgagtgtg tagaaatgtt ggatattgac
     2641 agtactcgag tggttgacca aattaccaca gtgtga
//
LOCUS       NM_001409239             987 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus mas-related G-protein coupled receptor member
            B8-like (LOC100361204), mRNA.
ACCESSION   NM_001409239 XM_039096209
VERSION     NM_001409239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Jul 12, 2022 this sequence version replaced XM_039096209.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-987               JAXUCZ010000001.1  107185689-107186675 c
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..987
                     /gene="LOC100361204"
                     /note="mas-related G-protein coupled receptor member
                     B8-like"
                     /db_xref="GeneID:100361204"
                     /db_xref="RGD:2320559"
     CDS             1..987
                     /gene="LOC100361204"
                     /note="mas-related G-protein coupled receptor member B8"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     B8-like"
                     /protein_id="NP_001396168.1"
                     /db_xref="GeneID:100361204"
                     /db_xref="RGD:2320559"
                     /translation="MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFG
                     LAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIP
                     LLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLL
                     SLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPV
                     TKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCAN
                     PIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQSSIP"
     misc_feature    91..924
                     /gene="LOC100361204"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    91..924
                     /gene="LOC100361204"
                     /note="mas-related G protein-coupled receptor subtype B,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmA_MrgprB; cd15107"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="LOC100361204"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    94..174
                     /gene="LOC100361204"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320235"
     misc_feature    190..273
                     /gene="LOC100361204"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    190..273
                     /gene="LOC100361204"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="LOC100361204"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    order(253..255,262..264,268..270,310..327,331..336,
                     343..345,472..474,478..492,559..561,568..576,580..588,
                     592..597,706..708,715..720,724..729,736..738,772..777,
                     781..789,796..798,805..810)
                     /gene="LOC100361204"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="LOC100361204"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    310..396
                     /gene="LOC100361204"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320235"
     misc_feature    430..492
                     /gene="LOC100361204"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    430..492
                     /gene="LOC100361204"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320235"
     misc_feature    559..636
                     /gene="LOC100361204"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    559..636
                     /gene="LOC100361204"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="LOC100361204"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    646..738
                     /gene="LOC100361204"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320235"
     misc_feature    775..852
                     /gene="LOC100361204"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     misc_feature    775..852
                     /gene="LOC100361204"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320235"
     exon            1..987
                     /gene="LOC100361204"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactcaa gcatcccaga cccggaggct gacctcatcc aactgaatgg aagctaccac
       61 acagaaactt caccttgtgt catcgagtcc cgagtcatga ttttgctttc catcatcatt
      121 gccttctttg gcctggcagg aaatgccatg gttctgtggc ttctggcttt ccgcatgcgc
      181 aggaatgtct tctctgtcta catcctcaac ctggctgggg caaacttcct cttcctctgc
      241 actcacactg cattttccct ggaaaagatc attgtccttt ttcactccgt tcacatccac
      301 atcccattgt tgttctacac tctgtccaca cttgcttacc ttgcaggtgt gagcatggtc
      361 acagccatta gtgctgagta ctggttgtct ggcatttggc cctattggta tcagggccag
      421 cgcctaaaac acacaacaac tgtcatttgt actgggctct ggggtttggc cctgctcttg
      481 agcctcctgg aaggaaaaag ttgtggattc ctgggtagta cttataacca agatgtgtgt
      541 tggaaacttg atttcatcat agttgcatgg ttacttgttt tatttgctgt tctttctcga
      601 tccattcaag tcctactggt caggatcttc tgcggttcac agcggactcc tgtgaccaag
      661 ctgcatgtga ccattgtgct cacagcactg gtcttggtga tctgtggctt tcccttcgga
      721 attatcttct acctcttata ctggactaca gaagtttatt atattatgcc ttgtaattct
      781 ttccatgaga caattctcct cctgtcctac attaacagct gtgccaaccc catcatttgc
      841 ttacttgttg gctcaattag gcactgtaga ttccagtgtg ggactctcag gctgctactg
      901 cacagagcca tgcaagatat ccctgaggaa gaaggtgaag aacttgaaga agttgtagga
      961 gaacgagtac agagcagtat accctag
//
LOCUS       NM_001329883             717 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 6 like 1 (Psmb6l1),
            mRNA.
ACCESSION   NM_001329883
VERSION     NM_001329883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 717)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BN000325.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BN000325.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..717
                     /gene="Psmb6l1"
                     /note="proteasome 20S subunit beta 6 like 1"
                     /db_xref="GeneID:100360846"
                     /db_xref="RGD:2321312"
     CDS             1..717
                     /gene="Psmb6l1"
                     /note="proteasome subunit beta type-6; Proteasome subunit
                     beta type-6-like"
                     /codon_start=1
                     /product="proteasome 20S subunit beta 6 like 1"
                     /protein_id="NP_001316812.1"
                     /db_xref="GeneID:100360846"
                     /db_xref="RGD:2321312"
                     /translation="MAAALAVRGAISAPAFGPEALTPDWENREVSTGTTIMAVQFDGG
                     VVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIE
                     LNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAI
                     GGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVE
                     RQVLLGDQIPKVTISTLPPP"
     misc_feature    100..663
                     /gene="Psmb6l1"
                     /note="proteasome beta type-6 subunit. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that...; Region:
                     proteasome_beta_type_6; cd03762"
                     /db_xref="CDD:239731"
     misc_feature    100..663
                     /gene="Psmb6l1"
                     /note="proteasome beta type-6 subunit. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that...; Region:
                     proteasome_beta_type_6; cd03762"
                     /db_xref="CDD:239731"
     misc_feature    order(100..102,148..150,154..156,196..198,487..489,
                     598..600,607..612)
                     /gene="Psmb6l1"
                     /note="active site"
                     /db_xref="CDD:239731"
     misc_feature    order(100..102,148..150,154..156,196..198,487..489,
                     598..600,607..612)
                     /gene="Psmb6l1"
                     /note="active site"
                     /db_xref="CDD:239731"
     misc_feature    order(154..156,163..165,169..186,244..246,250..252,
                     295..297,331..333,340..345,349..354,361..363,370..372,
                     442..444,448..450,454..465,472..474,496..501,505..510,
                     517..525,571..573,592..603,610..615)
                     /gene="Psmb6l1"
                     /note="beta subunit interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239731"
     misc_feature    order(154..156,163..165,169..186,244..246,250..252,
                     295..297,331..333,340..345,349..354,361..363,370..372,
                     442..444,448..450,454..465,472..474,496..501,505..510,
                     517..525,571..573,592..603,610..615)
                     /gene="Psmb6l1"
                     /note="beta subunit interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239731"
     exon            1..717
                     /gene="Psmb6l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggccg ccttagctgt tcgtggagcc atctctgcac cggcctttgg gccggaggcg
       61 ctcactccag actgggaaaa ccgagaagtc tccacaggga ccacgatcat ggctgtgcaa
      121 tttgacgggg gcgtggttct aggagcagac tccagaacaa ccactgggtc gtacatcgcc
      181 aatcgagtga ctgacaagct gacccctatc cacgatcaca tcttctgctg ccgctcaggc
      241 tcggcagctg atacccaagc agtagctgat gctgtcacgt accagcttgg tttccacagt
      301 attgagctga acgagcctcc actagtgcac acagccgcca gtctctttaa ggagatgtgt
      361 taccgctaca gagaagatct gatggcagga atcatcatcg caggctggga ccctcaagaa
      421 ggagggcagg tgtactctgt tcccatggga ggtatgatgg taagacagtc ctttgccatc
      481 ggaggctccg ggagctcata tatctatggc tatgttgatg ctacctatcg ggaaggcatg
      541 accaaggatg aatgtctgca attcactgcc aatgctcttg ctttggctat ggaacgggat
      601 ggctccagtg gaggagtgat ccgcttggca gccattcaac agtcgggggt agagcggcag
      661 gtgcttttgg gagaccagat ccccaaggtc accatctcca ctttgccacc tccctga
//
LOCUS       NM_001099505            2592 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 76 (Vom2r76), mRNA.
ACCESSION   NM_001099505 XM_001058271 XM_236825
VERSION     NM_001099505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000009.1.
            
            On or before Aug 17, 2007 this sequence version replaced
            XM_001058271.1, XM_236825.4.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000009.1  9795138-9795349
            213-504             JAXUCZ010000009.1  9808147-9808438
            505-1311            JAXUCZ010000009.1  9808809-9809615
            1312-1539           JAXUCZ010000009.1  9810299-9810526
            1540-1663           JAXUCZ010000009.1  9812275-9812398
            1664-2592           JAXUCZ010000009.1  9818564-9819492
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2592
                     /gene="Vom2r76"
                     /note="vomeronasal 2 receptor, 76"
                     /db_xref="GeneID:301154"
                     /db_xref="RGD:1588569"
     CDS             1..2592
                     /gene="Vom2r76"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 76 precursor"
                     /protein_id="NP_001092975.1"
                     /db_xref="GeneID:301154"
                     /db_xref="RGD:1588569"
                     /translation="MQSSWLYICCCFLQMPTLLSTIEIPSCIPKTKTLLYHDGSMVIS
                     AFFPIFYFYPQSETEWKTSFDTGNMFSMDERNYQLVLAMLFAIHEINWNSYILPNTSL
                     GLEIYNLLHFERNILRNVFHWLTGLSMSIPNYNCRKERDSAAVLTGISRKTSELIATV
                     LDLYKFPQITFGPFDHVLTDRNQFPSLYQVAPNDISVFYGIASLMLHFNWTWVGLFTT
                     DDHGGAQFLSDLKKELDENRICIAFVETVSFVGESVYNILNDNQELNLQSSANVIIIY
                     GEIAFILTVIESRHRKHILKKVWVMNSKWSGQKFEVYEMLDLSHGTLTFSPHHEEIFG
                     FTNFIQQATPIKYPEDICLHILWKRYFNCSLLHSNCKIFDNCLPNASLELLPGNIFEM
                     GMTEESYNVYNAVYAVAHSLHDMILNQVQFHPQSKKDRIMLLPWQLHPFLKNIQVKNS
                     VDDHVVLDWKRKTDPEYDINNLWNFPTGLSLFVKVGTFSPRAPKRQQLSISEFMIEWP
                     IAFTEIPQSVCSESCTPGFRKVILESKPACCFDCTPCPENEISNETGMDQCFKCPETH
                     YTSAEKKHCLKKTVTFLAYDDPLGKGLTFVSLGFSALTIFVIGTFVNHRDTPIVKANN
                     RTLSYILLVTLTLCFLCPLLFIGLPNTATCILQQNVFGILFTVALSTVLAKTTTVVIA
                     FKITAPGRKERWLLISQAPNFIIPVCTLIQVLLSGIWLGTSPPFVDMDAHSEHGYIII
                     LCNKGSTFAFYCTLAYLGVMAFGSYLMAFLSRNLPDTFNEAKFLSFSMLVFCCVWVTF
                     LPVYHSTTGKFMVAMEVFSILASSASILSLIFAPKCYIILFRPERNTFHFIRDKRQNR
                     CKNLIKT"
     sig_peptide     1..60
                     /gene="Vom2r76"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    124..1521
                     /gene="Vom2r76"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    124..1521
                     /gene="Vom2r76"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(223..225,514..519,1189..1191)
                     /gene="Vom2r76"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(223..225,514..519,1189..1191)
                     /gene="Vom2r76"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(337..339,346..348,475..477,736..738)
                     /gene="Vom2r76"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(337..339,346..348,475..477,736..738)
                     /gene="Vom2r76"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1543..1701
                     /gene="Vom2r76"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1543..1701
                     /gene="Vom2r76"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1762..2517
                     /gene="Vom2r76"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1762..2517
                     /gene="Vom2r76"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1762..1839
                     /gene="Vom2r76"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1762..1839
                     /gene="Vom2r76"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1771..1773,1780..1785,1792..1797,1801..1806,
                     1906..1908,1918..1920,1927..1932,1954..1956,1966..1968)
                     /gene="Vom2r76"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1771..1773,1780..1785,1792..1797,1801..1806,
                     1906..1908,1918..1920,1927..1932,1954..1956,1966..1968)
                     /gene="Vom2r76"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1873..1938
                     /gene="Vom2r76"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1873..1938
                     /gene="Vom2r76"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1933..1935,1969..1974,1981..1986,1993..1995,
                     2233..2235,2248..2250,2257..2262,2269..2271,2371..2373,
                     2380..2385,2392..2394,2404..2406,2428..2433,2440..2442,
                     2449..2451,2461..2463)
                     /gene="Vom2r76"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1933..1935,1969..1974,1981..1986,1993..1995,
                     2233..2235,2248..2250,2257..2262,2269..2271,2371..2373,
                     2380..2385,2392..2394,2404..2406,2428..2433,2440..2442,
                     2449..2451,2461..2463)
                     /gene="Vom2r76"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1963..2037
                     /gene="Vom2r76"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1963..2037
                     /gene="Vom2r76"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2107..2157
                     /gene="Vom2r76"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2107..2157
                     /gene="Vom2r76"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2236..2316
                     /gene="Vom2r76"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2236..2316
                     /gene="Vom2r76"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2338..2409
                     /gene="Vom2r76"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2338..2409
                     /gene="Vom2r76"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2422..2499
                     /gene="Vom2r76"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2422..2499
                     /gene="Vom2r76"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..212
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
     exon            213..504
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1311
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1539
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1663
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2592
                     /gene="Vom2r76"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcagtcct cttggcttta tatctgctgc tgctttctac agatgccaac tctcctcagc
       61 accattgaaa ttccttcttg catacccaaa acaaaaaccc tattatacca tgatgggtcc
      121 atggtcatta gtgcattttt tcctattttt tatttttacc ctcaaagtga aacagagtgg
      181 aaaacatctt ttgacacagg caatatgttt tcgatggatg aaagaaacta ccagctagtt
      241 ttggccatgc tatttgcaat ccatgagatc aactggaact catatatttt accaaacact
      301 tctcttggac ttgagattta taatctgcta cattttgaaa ggaatattct gaggaatgta
      361 ttccattggc tcacaggttt gagcatgtcc atccctaatt acaactgtag aaaggagaga
      421 gattcagctg ctgtacttac aggaatttca cggaaaacat ctgaactcat tgcaacagtg
      481 ttggatcttt acaaatttcc tcagattact tttgggccct ttgatcatgt tcttactgac
      541 agaaaccagt ttccatctct gtaccaggtg gcccccaatg acatatctgt gttttatggc
      601 attgcctctt tgatgctcca tttcaactgg acttgggtgg gactgttcac cacagatgac
      661 catggaggtg ctcagtttct gtcagacttg aaaaaggagc tagatgagaa tagaatctgc
      721 atagcatttg tggaaacagt atcatttgtg ggagaatcag tatataatat tctgaatgat
      781 aatcaggagc tcaatctgca gtcatcagca aatgtgatca taatttatgg agaaattgct
      841 tttatattaa ctgtaataga aagtagacat agaaaacata tactgaaaaa agtttgggtc
      901 atgaactcaa aatggagtgg ccaaaaattt gaagtatatg aaatgttaga tttatctcat
      961 ggaactctca ctttttcacc ccatcatgag gagatttttg gtttcacaaa ttttatacag
     1021 caagccaccc ctatcaagta cccagaggac atatgtcttc atatcttgtg gaagagatat
     1081 ttcaattgct cacttttgca ttctaattgt aaaatatttg ataactgtct acccaatgcc
     1141 tctttggaat tgttgccagg gaatattttt gaaatgggca tgacagaaga gagttacaat
     1201 gtgtacaatg ctgtgtatgc agtggcccac agccttcatg atatgattct caatcaagta
     1261 cagtttcacc cacagtcaaa aaaggatagg attatgttac ttccctggca gcttcaccct
     1321 tttctgaaga atattcaagt gaaaaattct gttgatgacc atgtggttct ggactggaaa
     1381 agaaagacag atccagagta tgatattaac aacctttgga atttcccaac aggtctttca
     1441 ctatttgtga aagtgggtac attttctcca agagctccca aaaggcagca attatcaata
     1501 tctgaattta tgattgaatg gcctattgca tttacagaga tccctcaatc tgtatgcagt
     1561 gagagctgca ctccgggatt caggaaagtc attctggaga gcaagcctgc ctgttgcttt
     1621 gactgcaccc cttgcccaga gaatgagatt tccaatgaga caggtatgga ccagtgtttc
     1681 aaatgtccag aaactcatta tacaagtgca gaaaagaagc actgcctcaa gaaaactgtg
     1741 acctttctag cctatgatga tcccttgggt aagggactga cattcgtgtc tctgggattc
     1801 tcagcactca caatttttgt cattggaacc tttgtaaatc acagagacac tccaattgtc
     1861 aaggccaata atagaactct cagttacatc ttgcttgtca ctctcaccct ctgtttcctc
     1921 tgccccttgc tcttcattgg ccttccaaac acagcaactt gtatcctgca gcagaacgtg
     1981 tttggaattc tgttcacagt ggccctatct actgtgttgg ccaaaaccac cactgtagtt
     2041 atagccttca agattactgc tccaggaaga aaggaaagat ggttgctgat atcacaggcc
     2101 cctaatttca tcattccagt ttgtaccctg atacaagtac ttctttctgg tatatggctg
     2161 ggaacatctc ctccatttgt tgacatggat gctcattctg aacatgggta catcatcatt
     2221 ctatgcaaca agggatcaac ttttgccttc tattgcactc tggcctacct gggagtcatg
     2281 gcctttggta gttacctcat ggctttcttg tccaggaatc tacctgacac attcaatgaa
     2341 gccaagttcc tgtctttcag catgctggtg ttctgctgtg tctgggtcac attcctccct
     2401 gtctatcaca gcaccacagg gaagttcatg gtggctatgg aagttttctc tattctggcc
     2461 tctagtgcta gcattttaag cctgatcttt gcccccaagt gctacatcat tttgttcagg
     2521 ccagaaagaa atacatttca ttttatcagg gataaaagac aaaacagatg caaaaattta
     2581 attaaaacat ag
//
LOCUS       NM_001191706            1206 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus arylacetamide deacetylase-like 2 (Aadacl2), mRNA.
ACCESSION   NM_001191706 XM_227188
VERSION     NM_001191706.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_227188.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.8897.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000002.1  146273344-146273481
            139-361             JAXUCZ010000002.1  146276988-146277210
            362-431             JAXUCZ010000002.1  146281816-146281885
            432-603             JAXUCZ010000002.1  146283470-146283641
            604-1206            JAXUCZ010000002.1  146293351-146293953
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..1206
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /note="arylacetamide deacetylase-like 2"
                     /db_xref="GeneID:295076"
                     /db_xref="RGD:1563197"
     CDS             1..1206
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /codon_start=1
                     /product="arylacetamide deacetylase-like 2"
                     /protein_id="NP_001178635.1"
                     /db_xref="GeneID:295076"
                     /db_xref="RGD:1563197"
                     /translation="MGFKALCVGLLCVSFLSYIYTPMPDNIEEPWKLIALDAVAKTFS
                     LTALCLENIGVMRYEEFISMIINLDYTQPHSDEHITVTDTAFVDIPVRLYLPKSKSEA
                     PRRAVIYFHGGGFCFGSFKQRAFDFLNRWTASKLDAVVVGVDYRLAPQHHFPAQFEDG
                     VTAVKFFLQDKMLTKYGVDPTRIAISGDSSGGTLAAAVTQQVQIDPEVKHKFKLQALL
                     YPGLQVIDTHLPSHLENERGIVLTRDIAIKLVSLFFTKDEALQWAMRKNQHMPLESKH
                     LFRFVNWSALLPDKFRKNYVYTEPVLGRSAFSLPALMDHRALPLLANDAHLQHLPQTY
                     ILTCQYDVLRDDGIMYASRLQSVGVEVYHDHVEDGIHGALSYMTSPLHLNLGLRIRDM
                     YVSWLDKNL"
     misc_feature    319..1116
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_3;
                     pfam07859"
                     /db_xref="CDD:400284"
     misc_feature    319..1116
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /note="alpha/beta hydrolase fold; Region: Abhydrolase_3;
                     pfam07859"
                     /db_xref="CDD:400284"
     exon            1..138
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /inference="alignment:Splign:2.1.0"
     exon            139..361
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /inference="alignment:Splign:2.1.0"
     exon            362..431
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /inference="alignment:Splign:2.1.0"
     exon            432..603
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /inference="alignment:Splign:2.1.0"
     exon            604..1206
                     /gene="Aadacl2"
                     /gene_synonym="RGD1563197"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggattta aagctctctg tgtggggctg ctttgtgtta gctttttatc ttatatttat
       61 acacctatgc ctgacaacat tgaagaacct tggaaactaa tagccctgga tgcagttgct
      121 aaaactttct cccttacggc tctgtgtctt gaaaacatag gtgttatgag atatgaagaa
      181 tttatctcca tgataatcaa tctggattac acacaaccac attctgacga acacattaca
      241 gtaactgaca ctgcctttgt tgacattcct gtgcgtttgt acttacccaa gagcaagtca
      301 gaagccccaa gacgagctgt gatctatttt catggaggag gtttttgttt cggaagtttt
      361 aagcagaggg cttttgattt cctgaataga tggactgcaa gcaaacttga cgctgttgtt
      421 gtaggagtag actacaggct agctcctcag catcactttc ccgcacaatt tgaagatggt
      481 gtcacagcag tcaagttttt tcttcaggat aaaatgctta ccaagtatgg agtagatcct
      541 acccgaattg ctatctcagg agacagttct ggaggcactc tggctgcagc agtgacacaa
      601 caggtgcaga ttgatcccga agtaaagcat aaattcaagc tgcaagctct actttatcct
      661 ggcttacagg tgattgacac tcacttgcca tcacatctag agaacgaacg tggtatagtt
      721 ctgacaaggg acatagccat aaaacttgtg agtttgtttt tcaccaagga tgaggcactt
      781 caatgggcaa tgagaaaaaa ccagcacatg cctctggagt ccaaacatct gttcaggttt
      841 gttaactgga gtgctcttct ccctgacaag tttagaaaga actatgtgta cactgagcct
      901 gtgcttggaa gatcggcctt ctctctgcca gctctgatgg accacagagc attgcccttg
      961 ttagccaatg atgctcactt acaacacttg ccacaaacat acattcttac ctgtcaatat
     1021 gatgtcctga gagatgatgg aatcatgtat gcttcaagac ttcaaagtgt tggagtagaa
     1081 gtatatcacg accatgttga ggatggaatc catggggcct tatcgtatat gacatcacca
     1141 ctccacttga atctagggct gagaataaga gatatgtatg ttagttggct ggataagaat
     1201 ctataa
//
LOCUS       NM_001099513            2559 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 64 (Vom2r64), transcript
            variant 2, mRNA.
ACCESSION   NM_001099513 XM_001060234
VERSION     NM_001099513.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 1, 2024 this sequence version replaced NM_001099513.2.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000012.1  24123536-24123735
            201-492             JAXUCZ010000012.1  24133210-24133501
            493-1299            JAXUCZ010000012.1  24134245-24135051
            1300-1530           JAXUCZ010000012.1  24140993-24141223
            1531-1662           JAXUCZ010000012.1  24141695-24141826
            1663-2559           JAXUCZ010000012.1  24152411-24153307
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2559
                     /gene="Vom2r64"
                     /note="vomeronasal 2 receptor, 64"
                     /db_xref="GeneID:681079"
                     /db_xref="RGD:1584665"
     CDS             1..2559
                     /gene="Vom2r64"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 64 isoform 2"
                     /protein_id="NP_001092983.3"
                     /db_xref="GeneID:681079"
                     /db_xref="RGD:1584665"
                     /translation="MPTWIFFFFTLKLPMLLCKLFTHECFVSFIDNVYQDGDMVISAF
                     LPLYTYQTSQHTEGAENKDVSARIAPQNYQFVMALIFAIEEINRNPILLPNMTLGYNI
                     HSAGAIGSETVVSFLKWLTGQDRLIPNYTCKTKEKSVAAITGTTWEISSLIGIFLSLY
                     KYPQLSIGPFEQSMNNSEEFPFLYQMAAKESSLALGMVSLFVHFKWNWVGLVISEDEN
                     GVNFVTDLIPQMERNTVCVAFMEFIPVTHMMDLENTYEYPIRIMRNPAKVVIIYANTD
                     SSLGVLFRRWEYILLWRIWVTTSQWEVVTSMRHLILDSFHGTLIFSKRQGDISTFKEF
                     VKSVRPSKYPDDIFLARLWEIYFGCAISNATCKSLKNCSSRGNLGLLPWYLFDIAVST
                     GSYHVYNAVYAVAHTMHKMLIQEIDIEGMKNGGSMDFPPLKLNSLLKNIKFMNPGGDP
                     ISLNPSESLHIDYDILNFWDFPQGLTYKVKVGTFSPYFPPGQQLSISEDRIEWSIGVE
                     QQIPVSVCSEICGPGFRKSLQEGKAACCFDCVLCSENEISNGTGKCCVKCTEDQYANT
                     DRTVCIQKAVTFLALENPLGMTLASMALCFSILTSFVLGIFVKHQNTPVVKANNRTLS
                     YILLISLTFCFLCSFLFIGQPNAVTCILQQTTFGVVFTVAVSTVLAKTITVILAFKST
                     APGRRLRWLLISGAPKFIIPICTLIQTVFCGVWLRISPPFVDTDAQSEHGHIIIMCNK
                     GSVTAFYCVLGYLGALSLVSFTVAFMARNLPDAFNEAKFLTFSMLVFLSVWVTFLPVY
                     HSTKGKIMVAVEVFSILASSTGLLGCIFIPKCYIILARPEMNSLKCRRNRVQWK"
     misc_feature    118..1509
                     /gene="Vom2r64"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1509
                     /gene="Vom2r64"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r64"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(211..213,502..507,1177..1179)
                     /gene="Vom2r64"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r64"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(325..327,334..336,463..465,724..726)
                     /gene="Vom2r64"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1692
                     /gene="Vom2r64"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1692
                     /gene="Vom2r64"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1750..2502
                     /gene="Vom2r64"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..2502
                     /gene="Vom2r64"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r64"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r64"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r64"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r64"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r64"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r64"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r64"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r64"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r64"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r64"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r64"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r64"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r64"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r64"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r64"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r64"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r64"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r64"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..200
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
     exon            201..492
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1299
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1530
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1662
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..2559
                     /gene="Vom2r64"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccactt ggattttttt cttttttacc ctgaagcttc ctatgcttct gtgcaaattg
       61 ttcacccatg agtgttttgt ttctttcata gacaatgtat accaggatgg ggatatggtg
      121 atcagtgcat tcttaccact ttatacctat caaacctccc aacacactga aggggcagag
      181 aacaaagacg tcagtgcacg gattgcccca caaaactacc aatttgtgat ggccttaatt
      241 tttgccatag aggagatcaa cagaaacccc atacttttac ctaacatgac gcttggatat
      301 aatattcaca gtgctggggc cattggaagt gagactgtag taagtttcct caagtggctc
      361 acagggcagg acagactcat tcctaactat acatgcaaaa ccaaggaaaa atctgtggct
      421 gcaatcacag gaacaacatg ggaaatttct tccttaattg gcatattttt gagtctttat
      481 aaatatccac agctgagcat tggacctttt gaacaaagta tgaataactc tgaggagttt
      541 ccttttttgt atcagatggc tgccaaagaa tcttctttgg ccttaggcat ggtctcattg
      601 tttgtccatt tcaaatggaa ttgggtgggg ctggtcatct cagaggatga gaatggtgtt
      661 aactttgtca cagacttgat tccacaaatg gaaagaaaca cagtctgtgt agccttcatg
      721 gaatttatcc cagttactca catgatggac ctggaaaaca cttatgaata ccctattcgg
      781 attatgagaa acccagccaa agttgttatc atttatgcta acactgactc ttccttaggt
      841 gtgctgttta gaagatggga atatatactt ctatggagaa tctgggttac cacatcacaa
      901 tgggaagtcg tcacttctat gagacattta attcttgact cattccatgg gactctcatc
      961 ttttcaaaac gccagggtga tatttctact tttaaagagt ttgtaaagtc agtgagacct
     1021 tccaaatacc cagatgacat ttttcttgca agactctggg agatttactt tggttgtgca
     1081 atatctaatg ctacctgtaa atcattaaaa aattgttcat ctagaggtaa cttggggttg
     1141 ttaccttggt acctctttga catagctgta agtactggca gttaccatgt atacaatgct
     1201 gtatatgctg tggcccacac catgcacaag atgcttattc aagaaataga catagaagga
     1261 atgaaaaatg gaggcagcat ggattttccc cccttgaagc tgaactccct gctgaagaac
     1321 attaaattca tgaatcctgg tggagatccg atatctttaa atccttcaga gagcttgcac
     1381 atagattatg acattctgaa cttctgggat tttccacaag gtcttacata taaagtgaaa
     1441 gtaggaacat tttctccata ttttccacct ggtcaacaat tgtcgatttc tgaggacaga
     1501 atagagtgga gtataggagt ggagcaacag attcctgtct ctgtatgcag tgaaatttgt
     1561 ggtcctggat tcagaaaatc tcttcaggaa gggaaagctg cttgctgttt tgattgtgtc
     1621 ctatgttcag aaaatgaaat ttccaatgga acaggcaagt gctgtgtgaa atgtacagag
     1681 gaccagtatg ccaacacaga tcggacagtc tgcatccaaa aagctgtgac atttctggct
     1741 ttggaaaacc ccttggggat gacactcgcc agcatggccc tatgcttttc tatcctcacc
     1801 tcatttgtcc tggggatttt tgtaaagcac caaaacactc ctgtggtgaa ggcaaataac
     1861 agaactctca gctacatctt gctcatctcc ctcactttct gctttctttg ctcatttcta
     1921 ttcattggtc agcccaacgc agtcacctgc atcctgcagc agaccacatt tggagttgtt
     1981 ttcacagtgg ctgtttctac tgtcttggca aaaaccatta cagtcatcct ggccttcaag
     2041 agcacagctc caggacgaag gttgaggtgg ttgcttatat caggagcacc gaaattcatc
     2101 attcccatct gtacactaat acaaactgtc ttctgtggag tctggctgag aatatcccct
     2161 ccatttgtgg acacagatgc acaatctgaa catggtcata tcattattat gtgcaacaag
     2221 ggctcagtaa cagccttcta ctgtgtgctg ggatacctgg gagctctgtc cctagtgagc
     2281 ttcacagtag cttttatggc caggaacctg cctgacgcct tcaatgaagc caagttcttg
     2341 accttcagca tgctggtatt cctcagtgtt tgggtcacat ttctccctgt ttaccacagt
     2401 actaaaggaa agatcatggt ggctgtggag gtcttctcca tcttggcctc cagcacaggt
     2461 cttctaggtt gtatctttat ccccaaatgt tatattattc ttgcaagacc tgaaatgaac
     2521 tcattgaaat gcagacgaaa tagagttcag tggaaataa
//
LOCUS       NM_001166761             966 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 1 receptor 104 (Vom1r104), mRNA.
ACCESSION   NM_001166761 XM_001076115
VERSION     NM_001166761.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with Janet Young. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Feb 3, 2010 this sequence version replaced XM_001076115.1.
            
            Sequence Note: A set of diverse V1R queries was aligned via BLAST
            to the RGSCv3.4 assembly to find candidate V1R-containing genomic
            regions. Open reading frames (ORFs) for V1R genes and pseudogenes
            were then identified.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-966               JAXUCZ010000004.1  124326103-124327068
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..966
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="vomeronasal 1 receptor 104"
                     /db_xref="GeneID:685945"
                     /db_xref="RGD:1587829"
     CDS             1..966
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="vomernasal 1 receptor Vom1r104; vomeronasal 1
                     receptor, A1"
                     /codon_start=1
                     /product="vomeronasal 1 receptor 104"
                     /protein_id="NP_001160233.1"
                     /db_xref="GeneID:685945"
                     /db_xref="RGD:1587829"
                     /translation="MSEFLFFSLQPLFSYMMNKNIRLHTNSNIRNTFFSEIGIGISGN
                     SLLLLFHIIKFIHGQRSRLTDLPIGLLLMLLMVAFIATDIFISQREWDDIICKFLVYL
                     YRIFRGLSLCTTCMLSVLQAIILSPRSSCLAKFKHKSPYYVSCAMLFLSALYMIISSH
                     LLVSIIATPNLTTNELMHVTQSCSILPVSYLMQSMFSILVAIRDIFLISLMVFSTWYM
                     VALLCRHRKQTQHLQGTSLSPKGSPEQRATRSILMLMSFFVLMSIFDSIVSCSRTMFL
                     NDPTSYNIQIFVMHIYATVSPFVFMSIEKHIVNFFRSMCVRVMNV"
     misc_feature    79..945
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="vomeronasal organ pheromone receptor type-1 family,
                     member of the seven-transmembrane G protein-coupled
                     receptor superfamily; Region: 7tm_V1R_pheromone; cd13949"
                     /db_xref="CDD:320087"
     misc_feature    79..945
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="vomeronasal organ pheromone receptor type-1 family,
                     member of the seven-transmembrane G protein-coupled
                     receptor superfamily; Region: 7tm_V1R_pheromone; cd13949"
                     /db_xref="CDD:320087"
     misc_feature    82..159
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    82..159
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320087"
     misc_feature    289..357
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    289..357
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320087"
     misc_feature    433..483
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    433..483
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320087"
     misc_feature    586..657
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     misc_feature    586..657
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320087"
     misc_feature    733..810
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320087"
     misc_feature    733..810
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320087"
     misc_feature    838..915
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320087"
     misc_feature    838..915
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320087"
     exon            1..966
                     /gene="Vom1r104"
                     /gene_synonym="V1ra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtgagt ttctgttctt ttctcttcag ccactgttct catatatgat gaataagaat
       61 atcagactcc acactaattc taacataaga aatacctttt tctctgaaat tggcattggt
      121 atctcaggca acagcctcct acttctcttc cacatcatca agttcattca tgggcagaga
      181 tccagactca ctgacctacc cattggactc ctactgatgc tactgatggt ggcattcata
      241 gccacagaca tttttatttc tcagagggaa tgggatgaca tcatatgtaa attccttgtc
      301 tacctgtaca gaatttttag aggtctctcc ctttgtacca cctgcatgct gagtgtcctg
      361 caggccatca ttctcagtcc cagaagctcc tgtttagcaa agtttaagca taagtcaccc
      421 tattatgtct cctgtgccat gcttttcctg agtgccctct acatgatcat tagcagtcac
      481 ctcttagtat ccatcattgc caccccaaat ttgaccacaa atgaacttat gcatgtcact
      541 cagtcctgct ctattctacc cgtgagttac ctcatgcaaa gcatgttttc tatacttgtg
      601 gccatcagag atatatttct tattagtctc atggtcttct cgacttggta catggtggct
      661 ctcttgtgta ggcacaggaa acagacacag catcttcagg gtaccagcct ttccccaaaa
      721 ggatccccag agcaaagggc cacccgttct atcctgatgc tcatgagctt ctttgtcctg
      781 atgtccatct tcgacagcat tgtctcctgc tcaagaacta tgttcctgaa tgatccaaca
      841 tcttacaata ttcaaatatt tgtgatgcac atctatgcca cagtcagccc ttttgtgttt
      901 atgagcattg aaaaacatat agttaacttt tttaggtcaa tgtgtgtgag ggtgatgaat
      961 gtttga
//
LOCUS       NM_001191969            1798 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus hyccin PI4KA lipid kinase complex subunit 1
            (Hycc1), mRNA.
ACCESSION   NM_001191969 XM_575330
VERSION     NM_001191969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Baskin,J.M., Wu,X., Christiano,R., Oh,M.S., Schauder,C.M.,
            Gazzerro,E., Messa,M., Baldassari,S., Assereto,S., Biancheri,R.,
            Zara,F., Minetti,C., Raimondi,A., Simons,M., Walther,T.C.,
            Reinisch,K.M. and De Camilli,P.
  TITLE     The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P
            synthesis at the plasma membrane
  JOURNAL   Nat Cell Biol 18 (1), 132-138 (2016)
   PUBMED   26571211
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Gazzerro,E., Baldassari,S., Giacomini,C., Musante,V., Fruscione,F.,
            La Padula,V., Biancheri,R., Scarfi,S., Prada,V., Sotgia,F.,
            Duncan,I.D., Zara,F., Werner,H.B., Lisanti,M.P., Nobbio,L.,
            Corradi,A. and Minetti,C.
  TITLE     Hyccin, the molecule mutated in the leukodystrophy hypomyelination
            and congenital cataract (HCC), is a neuronal protein
  JOURNAL   PLoS One 7 (3), e32180 (2012)
   PUBMED   22461884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575330.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.17930.1,
                                           SRR26643298.21290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000004.1  12024780-12024983
            205-283             JAXUCZ010000004.1  12048010-12048088
            284-385             JAXUCZ010000004.1  12057398-12057499
            386-565             JAXUCZ010000004.1  12061022-12061201
            566-646             JAXUCZ010000004.1  12061843-12061923
            647-762             JAXUCZ010000004.1  12062401-12062516
            763-858             JAXUCZ010000004.1  12062803-12062898
            859-975             JAXUCZ010000004.1  12064596-12064712
            976-1063            JAXUCZ010000004.1  12068458-12068545
            1064-1223           JAXUCZ010000004.1  12069377-12069536
            1224-1798           JAXUCZ010000004.1  12084023-12084597
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="hyccin PI4KA lipid kinase complex subunit 1"
                     /db_xref="GeneID:499975"
                     /db_xref="RGD:1562906"
     exon            1..204
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            205..283
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="down-regulated by Ctnnb1, A; family with sequence
                     similarity 126, member A"
                     /codon_start=1
                     /product="hyccin"
                     /protein_id="NP_001178898.1"
                     /db_xref="GeneID:499975"
                     /db_xref="RGD:1562906"
                     /translation="MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKV
                     IQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELIWCYLAVSASRNVHSSGCIE
                     ALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKV
                     VYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQ
                     HVRKYGGASSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPL
                     LVANAIKASLPPGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTE
                     LTGQEELTEITEVDEGFYSRAASSTSQSGLSISSHNCSHKTSVGKNQRRSGGSKAGAK
                     ERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSHGLAQTAATVF
                     SKSFEQVSGVPGPRSPSPAIGCVAGADAHRFSACSLQEEKLIYGSERIDLPLKCQAGQ
                     RGPPSVSITLSAD"
     misc_feature    296..1222
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="Region: Hyccin; pfam09790"
                     /db_xref="CDD:462903"
     misc_feature    296..1222
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="Region: Hyccin; pfam09790"
                     /db_xref="CDD:462903"
     exon            284..385
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            386..565
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            566..646
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            647..762
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            763..858
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            859..975
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1063
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1223
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagcggct ggcggcagtg gcggctgtcc gggctgggtt gtcagtcaga gagaggaggg
       61 aagatggctc gcccggactc gtgctgctag aaggagaggg gcaggtggct cagctgccgg
      121 cggagcgccg tcgccgggtc gccgtagtcg cagtggtcgc cgtggtcgtg aggggaggcc
      181 gcggtgggtt ccggagctgc tctggttgaa ggtttggaac aaatgtggaa aaatgttcac
      241 ctcagagata ggggttgtag aagaatggct gtcagaattt aagacactcc cagaaacatc
      301 tttgccaaat tatgccacaa atttgaaaga caagagttct ttagtttcat ctctctataa
      361 agttatccag gagccacaga gtgagttact agagcctgtg tgtcaccagc tctttgagtt
      421 ctaccgcagt ggggaggaac agctgctgcg gttcactctg cagtttctcc ccgagctgat
      481 ctggtgctac cttgccgtgt cagccagcag aaatgtgcac agcagcggct gcattgaggc
      541 ccttcttctg ggggtttaca acctggaaat agttgacaaa catggacata gtaaagtact
      601 gagttttaca attccgtctt tatccaaacc atctgtatac catgaacctt ccagcattgg
      661 gtctatggca ctgaccgaga gtgcactctc ccagcatggc ttatcaaaag tcgtgtacag
      721 tggcccccat cctcaacggg agatgctgac agcacagaac aggtttgaag tgctgacatt
      781 ccttctgctg tgttacaacg ctgccttaac ctacatgccc agtgtttctc tccagtcact
      841 gtgtcagatc tgttcaagaa tctgtgtgtg tggatatccc cgacaacacg taagaaagta
      901 cggaggtgca agcagcagga taccgatctc atctggcttc atggtacaga tgctaacagg
      961 cgtgtatttt gccatataca atggagaatg ggatctagct cagaaagcac tggatgacat
     1021 tatatacaga gcccagctag aactataccc agagccactg ctggttgcta atgcaataaa
     1081 ggcttcattg cctccgggtg ccatgaaatc tagtaaggaa ggtacacggt gtattcaagt
     1141 ggagatcaca ccaacgtcct ccagaatatc aaggaatgca gttaccagca tgtcaataag
     1201 aggtcacagg tggaaaagac atggagatac agagttaaca ggtcaagaag aactgacgga
     1261 gataactgaa gttgacgagg gattttattc cagggctgcg tctagcacca gccagtcggg
     1321 tctatcaatc agtagtcaca attgtagtca caagacaagt gtaggaaaga accagagacg
     1381 gtcgggagga agcaaagctg gagcaaagga gagagaaact gcaggggaat cttgcagaga
     1441 tcactttgct cgcaaacaaa cccagagagc ccagagcgag aaccttgagc ttctctctct
     1501 gaagagactg accttgacct ccagccagtc cctgcccaag cccagcagcc acggcttggc
     1561 tcagactgcg gccactgtat ttagtaaatc ctttgaacaa gtgagtgggg tcccaggccc
     1621 acgtagccct tctcctgcca ttggctgtgt tgctggggca gatgcccata gattttctgc
     1681 ttgtagtctc caagaagaga agcttattta cgggtcagaa aggattgacc ttccactgaa
     1741 gtgtcaagca ggccagcggg ggcctcctag tgttagcatc actctgtctg cagattaa
//
LOCUS       NM_001191793            1304 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus PIH1 domain containing 2 (Pih1d2), mRNA.
ACCESSION   NM_001191793 XM_236221
VERSION     NM_001191793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236221.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.45116.1,
                                           SRR26643295.31614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000008.1  59863271-59863505
            236-329             JAXUCZ010000008.1  59864123-59864216
            330-533             JAXUCZ010000008.1  59864427-59864630
            534-657             JAXUCZ010000008.1  59865807-59865930
            658-903             JAXUCZ010000008.1  59867166-59867411
            904-1169            JAXUCZ010000008.1  59867992-59868257
            1170-1304           JAXUCZ010000008.1  59871328-59871462
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1304
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="PIH1 domain containing 2"
                     /db_xref="GeneID:315645"
                     /db_xref="RGD:1310503"
     exon            1..235
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     exon            236..329
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     exon            330..533
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="upstream in-frame stop codon"
     CDS             357..1304
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /codon_start=1
                     /product="PIH1 domain-containing protein 2"
                     /protein_id="NP_001178722.1"
                     /db_xref="GeneID:315645"
                     /db_xref="RGD:1310503"
                     /translation="MKASSKGLLTHISQFWSMLDDLAENDPERYRNFIQQELKDGKQL
                     CADPEPQLCLQTKILKPKEKVLFINLCQWERIPAPQSATHPVPISVGRPEDFPETSDA
                     CTIIDVAYNPGVLQAAEKDQGIKDQLIRMAMRCIEERLQLTLAHSYHVTHFRVKGSIQ
                     RMKERLMGIKTHFPNFKEMMRKDNTLERIRSSTVSEPSHLPEVLLTKKQVSAKGRCLI
                     EEIASSEVQVEAKTPAYELKVVKDQNEKPLKIELKVELPGIKAVSLCELSVSEVDLLI
                     EVSEMYRLCLNLPESINTEMTTAKFIKNKSILIITMPLA"
     misc_feature    429..860
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="The alpha-crystallin-Hsps_p23-like superfamily
                     includes the alpha-crystallin domain (ACD) of
                     alpha-crystallin-type small heat shock proteins (sHsps)
                     and a similar domain found in p23-like proteins. sHsps are
                     small stress induced proteins with monomeric...; Region:
                     alpha-crystallin domain (ACD) found in
                     alpha-crystallin-type small heat shock proteins, and a
                     similar domain found in p23 (a cochaperone for Hsp90) and
                     in other p23-like proteins.; cl00175"
                     /db_xref="CDD:469641"
     misc_feature    429..860
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="The alpha-crystallin-Hsps_p23-like superfamily
                     includes the alpha-crystallin domain (ACD) of
                     alpha-crystallin-type small heat shock proteins (sHsps)
                     and a similar domain found in p23-like proteins. sHsps are
                     small stress induced proteins with monomeric...; Region:
                     alpha-crystallin domain (ACD) found in
                     alpha-crystallin-type small heat shock proteins, and a
                     similar domain found in p23 (a cochaperone for Hsp90) and
                     in other p23-like proteins.; cl00175"
                     /db_xref="CDD:469641"
     misc_feature    <1092..1295
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="PIH1 CS-like domain; Region: PIH1_CS; pfam18201"
                     /db_xref="CDD:408028"
     misc_feature    <1092..1295
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /note="PIH1 CS-like domain; Region: PIH1_CS; pfam18201"
                     /db_xref="CDD:408028"
     exon            534..657
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     exon            658..903
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1169
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1304
                     /gene="Pih1d2"
                     /gene_synonym="RGD1310503"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgggctcg ccggtcgccg tggaagctgt caggtgcagg aaggaagccg gcgctctcct
       61 gagagagaag cgggacgagc ccgctgagga gccagtccgg cactggagaa aagaaccgga
      121 actggatata gagacaccac tctaatttgc actccccgga ctcagttaga cggtgtaccg
      181 ggcctggtta ccatggtaac tagagtcaca gtttgtctcc aaactgagag aagaggtctg
      241 gaaggcacca agtcagccaa tattccagct attggaacaa cagtcctttc tgtttcctct
      301 gtatttgtga ggaccagaca gaagtacagg ttccaaaggc ctgagtcatc accatcatga
      361 aggcttcctc aaagggtctt ctcacccaca tctcccagtt ctggagcatg ctcgatgatt
      421 tggcagaaaa tgatcccgag cgctaccgga acttcattca gcaggagctg aaagatggca
      481 aacagctctg tgccgaccca gaacctcaac tctgtctaca gacaaagatc ctaaaaccaa
      541 aagaaaaagt actttttatc aacctatgtc agtgggaaag gatccccgca ccacaatcag
      601 ccactcatcc tgtacctata agtgttggca gaccagaaga tttccctgag acatcagatg
      661 cttgtaccat cattgatgtt gcctacaatc ctggtgttct gcaagcggca gaaaaagacc
      721 aaggaatcaa agatcagcta attaggatgg ccatgcggtg catcgaggag cgactccagc
      781 tcacacttgc acattcatac catgttactc attttagagt gaaaggaagc attcagagaa
      841 tgaaagaaag gctgatgggc attaaaactc acttcccaaa cttcaaagag atgatgagaa
      901 aagacaacac tcttgaaagg atcagaagca gtactgtgag tgaacccagt caccttcctg
      961 aggtgctatt gacaaagaaa caagtgtcgg ccaaagggag atgtcttata gaagagattg
     1021 ctagttcaga agtccaggtg gaggctaaga cacctgccta cgaattaaag gttgtaaagg
     1081 atcagaacga gaagccgctg aaaattgagc tgaaagtcga gttacctggg attaaggcag
     1141 tctctctctg tgagcttagt gtttctgagg ttgatttatt gattgaggtc tctgagatgt
     1201 accgattatg cctgaatctt ccagaatcga ttaatacaga aatgactaca gcaaaattca
     1261 taaaaaataa atccatatta atcattacaa tgcccctggc ataa
//
LOCUS       NM_001410264             961 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus RT1 class I, locus T24, gene 1 (RT1-T24-1),
            transcript variant 2, mRNA.
ACCESSION   NM_001410264
VERSION     NM_001410264.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 961)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   2  (bases 1 to 961)
  AUTHORS   Brorson,K.A., Hunt,S.W. 3rd, Hunkapiller,T., Sun,Y.H.,
            Cheroutre,H., Nickerson,D.A. and Hood,L.
  TITLE     Comparison of exon 5 sequences from 35 class I genes of the BALB/c
            mouse
  JOURNAL   J Exp Med 170 (6), 1837-1858 (1989)
   PUBMED   2584927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CM038666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487230.59626.1,
                                           SRR8487227.221037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                CM038666.1         2823209-2823306
            99-395              CM038666.1         2827486-2827782
            396-671             CM038666.1         2829697-2829972
            672-809             CM038666.1         2830100-2830237
            810-961             CM038666.1         2830413-2830564
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHRSP/BbbUtx"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..961
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="RT1 class I, locus T24, gene 1"
                     /db_xref="GeneID:361787"
                     /db_xref="RGD:1359499"
     exon            1..98
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..961
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histocompatibility 2, T region locus 24"
                     /codon_start=1
                     /product="RT1 class I, locus T24, gene 1 isoform 2"
                     /protein_id="NP_001397193.1"
                     /db_xref="GeneID:361787"
                     /db_xref="RGD:1359499"
                     /translation="MWSLIFCFLSHPQDTGARSHSLHYSYSAVTEPGPGVPAFFASGF
                     VDNQPFIHYDSRKMEAEPCADWLRENPYYFDEETQVFTNRMKIFQLSLRNIQQYYNSS
                     GDRSQRADGFHQQADPPQTTVTHHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQ
                     DMELVETRPTGDGTFQKWAAVVVPLGKEQKYTCHVEHEGLPEPLTQRWEAPPGTDSNM
                     GINVIAVVLQAVAIIAAVAIIIVTVVRRRRRRRRNTGGEGDYTPAPRSLSIFIQPAPQ
                     ARRSWLTQQAWLAWKSHASTPIITPLPA"
     misc_feature    101..>364
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    101..>364
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I Histocompatibility antigen, domains alpha 1
                     and 2; Region: MHC_I; cl08246"
                     /db_xref="CDD:471794"
     misc_feature    395..670
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    395..670
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Class I major histocompatibility complex (MHC)
                     alpha chain, alpha3 immunoglobulin domain; member of the
                     C1-set of Ig superfamily (IgSF) domains; Region:
                     IgC1_MHC_I_alpha3; cd07698"
                     /db_xref="CDD:409495"
     misc_feature    398..421
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    398..421
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409495"
     misc_feature    443..472
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    443..472
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409495"
     misc_feature    order(452..454,458..460,539..544,548..556,572..574,
                     578..580)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(452..454,458..460,539..544,548..556,572..574,
                     578..580)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409495"
     misc_feature    order(473..481,563..565,638..640)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    order(473..481,563..565,638..640)
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="MHC binding domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:409495"
     misc_feature    485..502
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    485..502
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409495"
     misc_feature    509..520
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    509..520
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409495"
     misc_feature    530..556
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    530..556
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409495"
     misc_feature    563..595
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    563..595
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409495"
     misc_feature    614..637
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    614..637
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409495"
     misc_feature    656..667
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     misc_feature    656..667
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409495"
     exon            99..395
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            396..671
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            672..809
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
     exon            810..961
                     /gene="RT1-T24-1"
                     /gene_synonym="H2-T24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaggaaa gacttacaca atgtcctgac accacgtcct gacaccatgt ggtctctgat
       61 cttctgcttc ctgagccacc cccaagacac tggagcccga tcacactctc tgcactattc
      121 ttactcagcc gtgacagagc cgggcccagg agttcctgca ttttttgcca gtggctttgt
      181 agataaccag cccttcatcc actatgacag taggaagatg gaggcagagc cttgtgctga
      241 ctggctgagg gaaaatccat attactttga tgaggagacc caggttttca ccaatcggat
      301 gaagatcttc cagttgagcc tgagaaacat tcagcaatac tacaacagct ctggtgaccg
      361 gagtcagaga gcagacggct tccaccagca agcagaccct ccacagacaa cagtgacaca
      421 ccaccccaga cctgaaggtg atgtcaccct gaggtgctgg gccctgggct tctaccctgc
      481 tgacatcacc ctgacctggc agttgaatgg ggaggacctg acccaggaca tggagcttgt
      541 ggagaccagg cctacagggg atggaacctt ccagaagtgg gcagctgtgg tggtgcctct
      601 tgggaaggag cagaagtaca catgccatgt ggagcatgag gggctgcctg agccgcttac
      661 ccagagatgg gaggctcctc caggcactga ctccaacatg ggaatcaatg ttattgctgt
      721 tgttcttcaa gctgtggcca tcattgcagc tgtggccatc atcatagtta ctgttgtgag
      781 gaggaggagg aggaggagga gaaacacagg tggggaagga gactacaccc ctgctcctcg
      841 cagcctttcc atttttatcc agcctgcacc ccaagcccgc aggagctggc taacccagca
      901 agcctggctg gcgtggaagt ctcatgcctc aacccccatc atcacacctc tgcctgccta
      961 g
//
LOCUS       NM_001329890            3112 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 3, mRNA.
ACCESSION   NM_001329890 XM_006223432 XM_006229903
VERSION     NM_001329890.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169022.1.
            
            On or before Aug 4, 2016 this sequence version replaced
            XM_006229903.3, XM_006223432.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3112
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..284
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..459
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    394..396
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             415..1638
                     /gene="Xndc1"
                     /note="isoform 1 is encoded by transcript variant 3; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 1"
                     /protein_id="NP_001316819.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQ
                     LKVEFQLERAVPISYIDVGNCGCAFLQIDVGRSSWPLDRPFVTLLPATMLMSLTDSKE
                     GKNRSGVRMFKDDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDP
                     VKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQL
                     QPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRG
                     KRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSI
                     EALPRHAATCGESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICELQFSAR
                     EIEEHASVCGEVFPA"
     misc_feature    415..864
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    415..864
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            460..601
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..757
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..936
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1022
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1195
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1271
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1402
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..3088
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata tatattaaaa
       61 actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct gtacttcctc
      121 agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg ttttgggcta
      181 cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa taagatctga
      241 gcaccgaaac tgaagctact acgacatgaa gtttatggac gcgggagtaa tgtaaggact
      301 cttcttcttc caaaagctac caagagcaaa acatagaccg tgtcaccgtg gttacagaag
      361 acatcctggg aggaagcata tctgcctcgc aaataaagaa gctggtggcc tccgatggct
      421 cctgtgaaga tcagccatgt ggtgtcattt tcctctcagg atcccaaata tcctgtggag
      481 aacttgctga acccagacag tcataaggga ccttggctca gctgccctcg ggacaagact
      541 gggcaactga aagtggagtt tcagctggag agagcagtgc ccataagcta catcgatgtc
      601 ggtaactgtg gctgtgcttt tctacagatt gacgtgggtc gttcttcttg gcccctggac
      661 agaccttttg tcaccctgct ccctgcaacc atgctcatgt ccctcactga ctcaaaggag
      721 gggaagaacc gctcaggggt ccggatgttt aaagatgatg attttctgat tccagcctca
      781 ggagaatcat gggatcgact tcgattgacc tgctcccaac ctttcacacg tcatcaatcc
      841 tttggcctgg ccttcctccg agtacgttcc tctctggact ctctgtctga ccctgtaaag
      901 gatccctcat cccctgggag ctctgggctt aatcagaact cttctgataa gctggagtct
      961 gatcctagcc cctggctgac taatccttct atccggagga ccttcttccc agatccccag
     1021 acgagcacca aggaaatttc agcgctcaag ggtatgttga agcagttgca gccagggcct
     1081 ctggggcggg cagcccgcat ggtgctttct gctgcccata aggcacctcc agccagtgtc
     1141 gtaagcccaa acaatagcca tggagaacca gattccagtc atcccgagcg tgcagagccc
     1201 agagcagaag aaccaaacag gaagaacaat gcaagcagag ggaagaggag gaaagtccag
     1261 gagcaaagga gaccgttgtc cagctcaagc tctcagccaa ataggagggc aacaggaagg
     1321 acaaagcaaa gacagcaacg acctcaggcc aaaagtgatg gcagtggtgt gcaggctact
     1381 ggacagtgtc ccatttgtac aggttccttc agtattgagg ctcttccccg gcatgctgcc
     1441 acttgtggag agagctcccc accccagcca gcttctccta cctccttgtc ttcctcagag
     1501 tctgtgctgt gggtgtcttc cccagagagc tcgccgccac catcttcctg ggtccaatgc
     1561 cctatttgtg aattacagtt ctcggcaaga gaaatagaag aacatgccag cgtgtgtggg
     1621 gaagtttttc cagcctgagc agtgacattc tgctaaccct ttcttgatgt tggagcctgg
     1681 ggaatggatc tcttgtggct aagaagcatt ggtcccctcc cttctgtgat tacctcagga
     1741 ctctgcctgc ctgaggacac tttggaccca gcttgctccc cattcccgtt gccaaggctg
     1801 tgtcactatg gtacccaatt ctcataagga tattttcccc ttagaacata tttggtagaa
     1861 ttgatgatct ctccaaggcc ttagaacact atctagaatg tgatttccaa tgcccatttc
     1921 cctgaaagga aaacggaggc tcacctaggg ggaaatactg cctgaaaatt ataaagtcct
     1981 atgatggtct gggaagatga gtgagtcttg agcatgacac tgacactgag tcccatctga
     2041 ccttgacctt ctatatcttt catgggtgtc tgccccaggt gtaatcagat actgccctga
     2101 aacttcacac tacttaccat aggtgtggaa tggacgttca gtgacacaaa aacccctcac
     2161 agggttctta aaggaaccag agagatttcc ttctaaggaa taggcgtggc tgtaaaagtt
     2221 tgagcaaatc tcgttctaac tatttgagat agttggacca tagtgtctcc ccaaggtccc
     2281 ctggagctgc gatggtccaa ttctgctttg aagaattatg cacgcttccc ttttccccag
     2341 gagatgtctt catgtggcac taacacccgt cccccttatc cccaaggtac agggcaggga
     2401 gagagcagct ggtcctggtg aagggagggc ttggggtggg gccttgagtg ggaatgaaag
     2461 agcatgtgag ccgcagtcaa gggagaggca gagcaggagt tcaagccttc agcccctgcc
     2521 cacagaagtg ggtgcagcca tggatcccct ttcggtaaga gacccttgct tccctcccct
     2581 cctcatccca gtccccaggg ggatgcaggg acagcctgct gctgttggtg ggagagcccc
     2641 tggattcctg atccagggcc tagaagaaaa gagcagggag ctggacctgg tagaacagga
     2701 cgcaacagta ccaaggaggg gagatgctct ccaaggtaga aggcagagtg agagtatccg
     2761 gtggagggaa agcaccttaa ggtcctacta gagtctttca tagagaaagg gtttagggaa
     2821 agtgcagctt aaagaccctc tgtgtgggca tgtctgaact tgtccttcag agagatgagc
     2881 agctacaaga tgggaactgg attcctgtcg gatgtgtata ggttaggtgc ctagtgcggc
     2941 cccaaccacc tactttaatc acctctcttc agggaactaa cttgggccct gttatgtctg
     3001 atttttataa gaatggaagt gggctgagta aatactcccc atactagctt ttcctacatg
     3061 agtctacata ataaaatggt gaacaagaaa aaaaaaaaaa aaaaaaaaaa aa
//
LOCUS       NM_001191801            2568 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif containing 71 (Trim71), mRNA.
ACCESSION   NM_001191801 XM_236676
VERSION     NM_001191801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Loedige,I., Gaidatzis,D., Sack,R., Meister,G. and Filipowicz,W.
  TITLE     The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA
            function
  JOURNAL   Nucleic Acids Res 41 (1), 518-532 (2013)
   PUBMED   23125361
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Chang,H.M., Martinez,N.J., Thornton,J.E., Hagan,J.P., Nguyen,K.D.
            and Gregory,R.I.
  TITLE     Trim71 cooperates with microRNAs to repress Cdkn1a expression and
            promote embryonic stem cell proliferation
  JOURNAL   Nat Commun 3, 923 (2012)
   PUBMED   22735451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Chen,J., Lai,F. and Niswander,L.
  TITLE     The ubiquitin ligase mLin41 temporally promotes neural progenitor
            cell maintenance through FGF signaling
  JOURNAL   Genes Dev 26 (8), 803-815 (2012)
   PUBMED   22508726
  REMARK    Erratum:[Genes Dev. 2012 Jun 15;26(12):1392]
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Rybak,A., Fuchs,H., Hadian,K., Smirnova,L., Wulczyn,E.A.,
            Michel,G., Nitsch,R., Krappmann,D. and Wulczyn,F.G.
  TITLE     The let-7 target gene mouse lin-41 is a stem cell specific E3
            ubiquitin ligase for the miRNA pathway protein Ago2
  JOURNAL   Nat Cell Biol 11 (12), 1411-1420 (2009)
   PUBMED   19898466
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Maller Schulman,B.R., Liang,X., Stahlhut,C., DelConte,C.,
            Stefani,G. and Slack,F.J.
  TITLE     The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse
            embryonic survival and neural tube closure
  JOURNAL   Cell Cycle 7 (24), 3935-3942 (2008)
   PUBMED   19098426
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Rybak,A., Fuchs,H., Smirnova,L., Brandt,C., Pohl,E.E., Nitsch,R.
            and Wulczyn,F.G.
  TITLE     A feedback loop comprising lin-28 and let-7 controls pre-let-7
            maturation during neural stem-cell commitment
  JOURNAL   Nat Cell Biol 10 (8), 987-993 (2008)
   PUBMED   18604195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236676.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               JAXUCZ010000008.1  123128204-123129016 c
            814-981             JAXUCZ010000008.1  123091373-123091540 c
            982-1116            JAXUCZ010000008.1  123080530-123080664 c
            1117-2568           JAXUCZ010000008.1  123077400-123078851 c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="tripartite motif containing 71"
                     /db_xref="GeneID:301042"
                     /db_xref="RGD:1566388"
     CDS             1..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /EC_number="2.3.2.27"
                     /note="Drosophila dappled/ vertebrate TRipartite Motif
                     protein related; B-box zinc finger, Filamin and NHL repeat
                     containing protein (123.8 kD) (lin-41); tripartite
                     motif-containing protein 71; protein lin-41 homolog;
                     tripartite motif containing 71, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase TRIM71"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM71"
                     /protein_id="NP_001178730.1"
                     /db_xref="GeneID:301042"
                     /db_xref="RGD:1566388"
                     /translation="MASFPETDFQICLLCKEMCGSPAPLSSSSSASSSSSQTSTSSAG
                     GGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEA
                     AGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRA
                     AAPAPQPPPGPAASPGSLLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVR
                     LTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLY
                     CDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQAIQLSIEQAQ
                     TVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLR
                     QNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRVMFTP
                     PDQALYLALKSFGFVSSGAFAPLTKAAGDGIKRALQGKVASFTVMGYDHNGEPRLSGG
                     DLMSVVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLYNQHIENSPFKVV
                     VKSGRSYVGIGLPVLSFGSEGDGEGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCG
                     SFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGT
                     KNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGV
                     AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVA
                     DSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVVDFGNNRILIF"
     misc_feature    1..303
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: RING-HC_TRIM71_C-VII; cd16589"
                     /db_xref="CDD:438251"
     misc_feature    1..303
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: RING-HC_TRIM71_C-VII; cd16589"
                     /db_xref="CDD:438251"
     misc_feature    4..6
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q2Q1W2; propagated from
                     UniProtKB/Swiss-Prot (D3ZVM4.1); acetylation site"
     misc_feature    76..144
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    376..531
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    553..681
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: Bbox1_TRIM71_C-VII; cd19812"
                     /db_xref="CDD:380870"
     misc_feature    553..681
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: Bbox1_TRIM71_C-VII; cd19812"
                     /db_xref="CDD:380870"
     misc_feature    790..927
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: Bbox2_TRIM71_C-VII; cd19796"
                     /db_xref="CDD:380854"
     misc_feature    790..927
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 71 (TRIM71) and similar proteins;
                     Region: Bbox2_TRIM71_C-VII; cd19796"
                     /db_xref="CDD:380854"
     misc_feature    901..1293
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    901..1293
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    order(943..948,952..960,967..969,976..978,1018..1023,
                     1030..1032,1039..1044,1051..1056,1063..1065,1084..1089,
                     1096..1098,1105..1110,1117..1122,1129..1131,1159..1164,
                     1171..1173,1183..1185,1192..1197,1204..1209,1213..1218,
                     1240..1242,1249..1254,1261..1263,1270..1275)
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467844"
     misc_feature    order(943..948,952..960,967..969,976..978,1018..1023,
                     1030..1032,1039..1044,1051..1056,1063..1065,1084..1089,
                     1096..1098,1105..1110,1117..1122,1129..1131,1159..1164,
                     1171..1173,1183..1185,1192..1197,1204..1209,1213..1218,
                     1240..1242,1249..1254,1261..1263,1270..1275)
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467844"
     misc_feature    1396..1701
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: Filamin"
     misc_feature    1405..1692
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="Filamin/ABP280 repeat; Region: Filamin; pfam00630"
                     /db_xref="CDD:395505"
     misc_feature    1405..1692
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="Filamin/ABP280 repeat; Region: Filamin; pfam00630"
                     /db_xref="CDD:395505"
     misc_feature    1711..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat domain of the tripartite
                     motif-containing protein 71 (TRIM71) and related proteins;
                     Region: NHL_TRIM71_like; cd14954"
                     /db_xref="CDD:271324"
     misc_feature    1711..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat domain of the tripartite
                     motif-containing protein 71 (TRIM71) and related proteins;
                     Region: NHL_TRIM71_like; cd14954"
                     /db_xref="CDD:271324"
     misc_feature    1738..1869
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 1"
     misc_feature    1786..1905
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    1786..1905
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    1879..2010
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 2"
     misc_feature    1927..2046
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    1927..2046
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2020..2151
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 3"
     misc_feature    2068..2178
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2068..2178
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2071..2181
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2071..2181
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2161..2292
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 4"
     misc_feature    2200..2322
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2200..2322
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2302..2433
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 5"
     misc_feature    2344..2463
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2344..2463
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2347..2439
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2347..2439
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2443..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZVM4.1);
                     Region: NHL 6"
     misc_feature    2485..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2485..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="NHL repeat [structural motif]; Region: NHL repeat"
                     /db_xref="CDD:271324"
     misc_feature    2491..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    2491..2565
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            1..813
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            814..981
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1116
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttcgt tccctgagac cgacttccag atctgcctgc tgtgcaagga gatgtgcggc
       61 tcgcccgcgc ctctctcctc cagctcgtcc gcctcttcat cgtcctcgca gacgtccacg
      121 tcgtcggcgg gcggcggcgg ccccggggcg gcggcgcggc gcctgcacgt cctgccctgc
      181 ctgcacgcct tctgccggcc gtgcctcgag gcgcaccggc tcccggctcc cggtggcgcc
      241 ggccccgccg aggcgctgaa gctgcgctgt cctgtgtgtg accagaaggt ggtcctggcc
      301 gaggcggcag gcatggacgc gctgccgtcg tccgccttcc tgctcagcaa cctgctggac
      361 gccgtggtgg ccaccgccga cgagccgccg cccaagaacg ggcgcgcggg tggcggcccc
      421 gggggcgcgg gcggccacag caatcaccgg caccacgcgc accacccggc ccagcgcgcc
      481 gccgctccag cgccgcagcc gccgcccggc ccggccgctt ctccagggtc gctgttgttg
      541 cgccggccgc acggctgcag ctcctgcgac gagggcaatg ctgcctcgtc gcgctgcctc
      601 gactgccagg aacacctgtg cgacaactgt gtccgcgcgc accagcgcgt acgcctcacc
      661 aaggaccact acatcgagcg cggcccgccg gggcctgcgg ccgcctccgc ggcgcagcag
      721 ctggggctcg ggccgccctt cgcaggcgcg cccttctcca tcctctcggt gttcccggag
      781 cgcctcggct tctgccaaca ccacgacgac gaggtactac atctgtactg cgacacctgc
      841 tccgtgccca tctgcagaga gtgcacactg ggccgccatg gcggccacag cttcgcctac
      901 ctccaggacg ccctacagga ctcacgggca ctcaccatcc agctgctggc cgacgcccag
      961 cagggccgcc aggccattca gctgagcatt gagcaggcgc agactgtggc agaacaagtg
     1021 gagatgaagg ccaaggtggt ccagtcggag gtcaaggccg tcacggcgag acacaagaaa
     1081 gctctggagg agcgtgagtg cgagctgctg tggaaggtgg agaagatccg gcaggtgaag
     1141 gctaagtctc tctacctgca ggtggagaag ctgcggcaga atctcaacaa gctggagagc
     1201 accatcagcg ccgtccagca ggtcctagaa gagggccgag ccctggacat cctgctggcc
     1261 cgagaccgga tgctggctca ggtgcaggag ctcaagacca tccggggcct cctgcagccc
     1321 caggaagatg accgagttat gttcacaccc cccgaccagg ccctgtacct tgccctcaag
     1381 tcttttggct ttgtcagcag tggggccttt gccccactca cgaaggccgc gggagatggc
     1441 atcaagcgag cccttcaggg aaaggtggcc tccttcactg tcatgggcta tgaccacaat
     1501 ggtgagcccc gcctctcagg aggtgacctg atgtcggtgg tggtccttgg ccctgatgga
     1561 aacctgtttg gtgcagaagt gagcgaccag cagaatggga cctacgtcgt gagctacagg
     1621 ccccagcttg agggtgaaca cttggtatca gtgacgctgt ataaccagca catcgagaac
     1681 agccccttca aggtagtggt caagtcgggc cgcagctatg tgggcatcgg gctcccagtg
     1741 ttgagctttg gcagcgaggg tgatggcgag ggtaagctct gcaggccctg gggcgtgagt
     1801 gtggataagg agggctacat catcgtggct gaccgcagca ataacagaat tcaggtgttt
     1861 aagccctgtg ggtctttcca ccacaagttt ggtaccctag gatctcggcc cgggcagttt
     1921 gaccgaccgg cgggggtggc ctgcgacgcc tcccgcagga tcgtggtggc cgacaaagac
     1981 aatcatcgca tccagatctt caccttcgag ggccagttcc ttctgaagtt tggcgagaaa
     2041 ggaaccaaga atgggcagtt taactacccg tgggatgtag cggtcaactc tgagggcaag
     2101 atcctggttt cagacacccg aaaccaccgc atccagctgt tcggacccga cggcgtcttc
     2161 ctgaataagt atggcttcga gggatctctc tggaagcact tcgactcccc acggggcgtg
     2221 gctttcaacc atgaaggtca cctggtagtc actgatttca acaaccatcg gctcctggtt
     2281 atccaccccg attgccagtc tgcccgcttc ctgggctctg agggcactgg caatgggcag
     2341 ttcctgcgac cacagggtgt ggctgtagac caggaagggc gaatcattgt cgccgattcc
     2401 agaaatcacc gtgtgcagat gtttgaggcc aacggcagct tcctgtgcaa gttcggtgct
     2461 caaggcagcg gcttcgggca gatggaccgc ccctcaggta tcgcggtcac cccggaagga
     2521 ttgatcgtcg tggtggactt tggcaacaat cgaatcctca tcttctaa
//
LOCUS       NM_001191920            1719 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 47 member 2 (Slc47a2),
            mRNA.
ACCESSION   NM_001191920 XM_573107
VERSION     NM_001191920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Gong,L., Goswami,S., Giacomini,K.M., Altman,R.B. and Klein,T.E.
  TITLE     Metformin pathways: pharmacokinetics and pharmacodynamics
  JOURNAL   Pharmacogenet Genomics 22 (11), 820-827 (2012)
   PUBMED   22722338
  REMARK    Review article
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XM_573107.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.37006.1,
                                           SRR26643293.63193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000010.1  46532796-46532954   c
            160-261             JAXUCZ010000010.1  46532618-46532719   c
            262-330             JAXUCZ010000010.1  46529244-46529312   c
            331-479             JAXUCZ010000010.1  46528089-46528237   c
            480-522             JAXUCZ010000010.1  46527494-46527536   c
            523-567             JAXUCZ010000010.1  46521107-46521151   c
            568-665             JAXUCZ010000010.1  46519893-46519990   c
            666-763             JAXUCZ010000010.1  46516951-46517048   c
            764-877             JAXUCZ010000010.1  46505140-46505253   c
            878-945             JAXUCZ010000010.1  46504183-46504250   c
            946-1054            JAXUCZ010000010.1  46499159-46499267   c
            1055-1130           JAXUCZ010000010.1  46498340-46498415   c
            1131-1200           JAXUCZ010000010.1  46497179-46497248   c
            1201-1333           JAXUCZ010000010.1  46495896-46496028   c
            1334-1428           JAXUCZ010000010.1  46492615-46492709   c
            1429-1483           JAXUCZ010000010.1  46491334-46491388   c
            1484-1719           JAXUCZ010000010.1  46490832-46491067   c
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1719
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="solute carrier family 47 member 2"
                     /db_xref="GeneID:497921"
                     /db_xref="RGD:1562382"
     CDS             1..1719
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="solute carrier family 47 (multidrug and toxin
                     extrusion), member 2"
                     /codon_start=1
                     /product="multidrug and toxin extrusion protein 2"
                     /protein_id="NP_001178849.1"
                     /db_xref="GeneID:497921"
                     /db_xref="RGD:1562382"
                     /translation="MEPAEDSLGAAIQPPELAPVPERSLRILLGLREALSSDVRQEAA
                     ALAALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLAS
                     ACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLFLRQDPEVAR
                     LAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALD
                     LGVVGSAWANTTSQFFLSALLFLYVWWKGIHIHTWGGWTRECFQEWSSYTRLAIPSMF
                     MVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGA
                     GNADQARCSCTTVLLCTGVCALLVGILLAALKDVVAYVFTNDKDIISLVSQVMPIFAP
                     FHLFDALAGTCGGVLRGTGKQKIGAVLNAIGYYGFGFPIGVSLMFAAKLGIIGLWAGL
                     IVCVFFQALSYLIYILRTNWNRVAEQAQVRAGLKSNKEMIPTPADLPILEREVIDGVI
                     LPDIIRPESQTGQLVVEENSQCVVPTVGEVLTGRQLVVYRGTALIVSIAVLIAGIVVR
                     VINDRG"
     misc_feature    151..1428
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="Eukaryotic members of the multidrug and toxic
                     compound extrusion (MATE) family; Region: MATE_eukaryotic;
                     cd13132"
                     /db_xref="CDD:240537"
     misc_feature    151..1428
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="Eukaryotic members of the multidrug and toxic
                     compound extrusion (MATE) family; Region: MATE_eukaryotic;
                     cd13132"
                     /db_xref="CDD:240537"
     misc_feature    order(841..843,853..855,931..933,940..942,1177..1179,
                     1189..1191,1270..1272,1348..1350,1360..1362)
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:240537"
     misc_feature    order(841..843,853..855,931..933,940..942,1177..1179,
                     1189..1191,1270..1272,1348..1350,1360..1362)
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:240537"
     exon            1..159
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            160..261
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            262..330
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            331..479
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            480..522
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            523..567
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            568..665
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            666..763
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            764..877
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            878..945
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1054
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1130
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1200
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1333
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1428
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1483
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1719
                     /gene="Slc47a2"
                     /gene_synonym="RGD1562382"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagccgg ccgaggacag cctgggcgcc gccatccagc ccccggagct ggccccggta
       61 ccggagcgca gcctgcggat cctgctgggc ctgcgagaag cgctgtcctc cgacgtgcgg
      121 caggaagcgg cggcgctggc ggcgctcgcg ggcccggtgt tcctggcgca gctgatgatc
      181 tttctcatca gcatcgtcag ttccatcttc tgcggacacc tgggcaaagt cgagctggac
      241 gccgtgacac tcgctgtttc cgttgtgaat gtcactggaa tttcagtcgg gactggctta
      301 gcctcggctt gtgacacact gatgtctcag tcctttggag gcaagaactt gaagcgcgtg
      361 ggggtcatac tccaaagggg catcctcatc ctgctgctct gctgcttccc ttgctgggcc
      421 atcttcctca acaccgagcg ccttctgctg ttcctaaggc aggatccaga agttgccagg
      481 ctagcccagg tttatgtgat gatttgcatc cctgcccttc ctgcggcatt cctgttccag
      541 ctacagacgc ggtatttaca gagccagggc atcattatgc cccaagttat cgttgggatc
      601 gcagcaaatg ttgtcaacgt gggcatgaat gccttcctgc tgtatgcctt ggacctcgga
      661 gtggtagggt cggcctgggc caacaccacc tcccagttct tcctgtccgc cctgcttttt
      721 ctctacgtgt ggtggaaggg aatccacatc cacacctggg gagggtggac aagggagtgc
      781 ttccaggagt ggagctccta cacccgcctg gccatcccca gcatgttcat ggtgtgcatc
      841 gagtggtgga ccttcgagat tgggaccttc cttgcaggcc ttgttaatgt gacagaactg
      901 ggagcccagg ccgtcatcta tgagctagct tctgttgcct acatggtgcc ctttggcttt
      961 ggtgtggctg ccagtgtccg agtgggcaat gctctggggg cagggaatgc tgaccaggcc
     1021 cggtgttcct gtaccactgt tctcctgtgt actggtgtct gtgcgctcct ggtgggaatt
     1081 ctgcttgcag ccttgaagga cgtggtcgcc tacgtcttca ccaatgacaa ggacataatt
     1141 tccctcgtga gtcaagtgat gcccattttt gctccctttc atctctttga tgcacttgca
     1201 ggcacctgtg gcggggtcct gagaggtaca ggaaaacaaa agataggtgc tgtcctgaac
     1261 gccattggtt actacgggtt tggttttccc atcggtgtgt cactgatgtt tgctgctaaa
     1321 cttgggataa taggcctctg ggctgggctg atagtctgtg tcttcttcca agccctctcc
     1381 tatctaatct acatcctgag gacaaactgg aacagagtcg cagagcaggc acaggttcga
     1441 gctgggctaa aaagcaacaa ggagatgatt cccaccccag cagatctgcc catcttggag
     1501 agagaagtta tcgacggagt gattttgcct gatatcatca gaccagagag ccagactggc
     1561 cagctggtgg tggaagaaaa cagccagtgc gtggtgccca ccgtcgggga ggtcttgacc
     1621 gggaggcagc tggttgtcta ccgtgggacg gctctgattg tttctattgc tgtcctcata
     1681 gcagggattg ttgtgcgagt tatcaatgac cgtggctga
//
LOCUS       NM_001135717            1788 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus RNA binding motif protein 46 (Rbm46), mRNA.
ACCESSION   NM_001135717 XM_227311
VERSION     NM_001135717.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Wang,C., Chen,Y., Deng,H., Gao,S. and Li,L.
  TITLE     Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2
            mRNA in early mouse embryos
  JOURNAL   Stem Cells Dev 24 (7), 904-915 (2015)
   PUBMED   25397698
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 8, 2008 this sequence version replaced XM_227311.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.12641.1,
                                           SRR26360181.1621883.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000002.1  170539894-170540068 c
            176-337             JAXUCZ010000002.1  170530190-170530351 c
            338-805             JAXUCZ010000002.1  170528773-170529240 c
            806-1588            JAXUCZ010000002.1  170527488-170528270 c
            1589-1788           JAXUCZ010000002.1  170497089-170497288 c
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1788
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /note="RNA binding motif protein 46"
                     /db_xref="GeneID:310548"
                     /db_xref="RGD:1560205"
     exon            1..175
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    148..150
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /note="upstream in-frame stop codon"
     exon            176..337
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1788
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /codon_start=1
                     /product="probable RNA-binding protein 46"
                     /protein_id="NP_001129189.1"
                     /db_xref="GeneID:310548"
                     /db_xref="RGD:1560205"
                     /translation="MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRK
                     FGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRG
                     YAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDE
                     MKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQV
                     DWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFV
                     HFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYA
                     NKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFN
                     SAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCT
                     TLEDAKELAAQFTLLHLDYNFRRSSINSLSPVSATLSTGTPSVLPYTSRPYSYPSYPL
                     SPTISLANGSHVGQRLYISNQASFF"
     misc_feature    238..1578
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    238..1578
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     exon            338..805
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1588
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1788
                     /gene="Rbm46"
                     /gene_synonym="RGD1560205"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggctccga ggcacgagga ctgcacgagc gccactggcc acgccctgcc ccgtccggcc
       61 ccgcggcgac tcctctggcc accgcttccg cccacagcgc tgatccaaag ctctggcggc
      121 ggtttgtgct cgttggtcca gggattttag gtctggcctt tgaagacccg acggggaatt
      181 gcagccatga acgaagagaa cactgatgga acaaatggat gcagtaaagt acgcactggc
      241 actcagaatg aagccgcatt gctggctctg atggaaaaga ctggctacaa catggtccaa
      301 gaaaatgggc aaaggaaatt tggtggtcct cctccaggtt gggaaggtcc acctccccct
      361 agaggttgtg aagtttttgt tggaaaaata cctcgtgata tgtatgaaga tgaattggtt
      421 cctgtatttg aaagagctgg gaagatatat gaatttcgac tgatgatgga atttagtggt
      481 gaaaatagag gttatgcttt cgtgatgtat actactaaag aagaagctca attagccatc
      541 cggattctta acaattatga gattcgacct gggaagttta ttggtgtgtg tgtaagcttg
      601 gataattgca gattatttat tggagcaatt cccaaagaaa agaaaaagga agaaattttg
      661 gatgaaatga agaaagttac agaaggtgtt gtagatgtga ttgtttatcc aagtgcaact
      721 gacaaaacca agaaccgcgg ttttgcattt gttgagtatg agtctcacag agctgctgct
      781 atggccagga gaaagctgat tccaggaaca tttcaactct ggggccacac cattcaggta
      841 gattgggctg atccagagaa agaagttgat gaggaaacca tgcagagagt taaagttctc
      901 tatgtaagaa atctaatgat ctcaaccaca gaggaaacaa ttaaagcaga attcaataag
      961 ttcaagcctg gtgcagtgga acgagtaaag aaacttagag attatgcatt cgttcacttt
     1021 ttcaaccggg aagatgcagt ggctgctatg tctgttatga atggaaaatg cattgatgga
     1081 gccagtattg aggtaaccct ggcaaagcca gtaaataaag aaaatacttg gcgacagcat
     1141 cttaatggcc agatcagccc caattcagaa aacctacttg tttatgctaa caaggaagag
     1201 agtcactcca aaagtctagg caagccacca actctcccca cgcgtctcaa tggtcagcat
     1261 agtccaagcc cccctgagat tgaaagatgt acttatcctt tttttcctgg aacaaagctt
     1321 accccaatta gtatgtattc tttaaaatcc aatcatttta attctgcagt gatgcatttg
     1381 gattattact gcaacaaaaa taattgggca ccaccagaat attatttata ttcaacaacc
     1441 agtcaggatg gaaaagtact cttggtgtat aaaatagtta ttcctgcaat tgcaaatgga
     1501 tcccagagtt acttcatgcc agataaactc tgcacaacgc tggaggatgc aaaggaactg
     1561 gcagctcagt ttacactgct tcatttggac tacaatttcc gtcgcagctc aataaatagt
     1621 ctttcccctg ttagcgctac cctctctact gggacaccca gcgtgcttcc ttatacttca
     1681 aggccttatt cttatccaag ctatcccttg tcaccaacaa tatcacttgc taatggcagc
     1741 catgttggac aacgactata tatctccaat caggcctcat tcttctga
//
LOCUS       NM_001099470            2595 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 11 (Vom2r11), mRNA.
ACCESSION   NM_001099470 XM_001058654 XM_218020
VERSION     NM_001099470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On or before Aug 19, 2007 this sequence version replaced
            XM_218020.3, XM_001058654.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000001.1  68191440-68191663   c
            225-519             JAXUCZ010000001.1  68185488-68185782   c
            520-1326            JAXUCZ010000001.1  68179843-68180649   c
            1327-1527           JAXUCZ010000001.1  68178887-68179087   c
            1528-1651           JAXUCZ010000001.1  68176269-68176392   c
            1652-2595           JAXUCZ010000001.1  68171875-68172818   c
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2595
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="vomeronasal 2 receptor, 11"
                     /db_xref="GeneID:292417"
                     /db_xref="RGD:1563778"
     CDS             1..2595
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 11"
                     /protein_id="NP_001092940.1"
                     /db_xref="GeneID:292417"
                     /db_xref="RGD:1563778"
                     /translation="MKMFSWIFITSFLQTPYLVFTFNLSICYYLITEDFHHEGDLMIG
                     AFFPVHTYYTVNKIPNVQFPNIYYYQDYYLQFNFKNYQYVLALEFAIEEINRNPNLLP
                     NLTLGFDFYNVKFTEKETLMNVCMWLTAHKRGKVLPNYNCEEKNFTAAFTGTSWTTSA
                     HIGTLLQLFRFPQLSIGPYDTALNDHGQYSSLYQMATKDTSLSHGIVSLMLYFRWSWV
                     GLLLPDDHKGNKVLSEFRDEMERERVCIAFVKMIPTTWTLYFNKQWKNMEEIEESSTN
                     VIIIYGDVDSLQGLMRNIGQRLLTGKVWVMNFEQDITDHADYFLLDSFHGSFIFTQHY
                     GESFEFTKFIQTVNPYKYPEDIYLPKMWHYFFKCSYSEVDCKLLDNCQANATLNVLPR
                     HIFDVSMSKESYNIYNAVYAVAHSLHEITLKQVQMQPCKNGEELLFYPWQINSFLRKN
                     MGLDWRQKRNEEYDILNLWNFPKGLGLKIKIGKYSENAPDGQQLTLSDQMIQWPEKFS
                     EIPQSVCSESCGPGFRKVTLEGQAVCCYNCTPCAENEISNETDVDHCVKCPESYYANT
                     EKNHCLQKAQSFLAYEDPLGMALTSISLLFSALTVIVVGIFVRHRHTPMVKANNRALS
                     YTLLISLNFCFLCSLNFIGQPNTATCILQQTIFGVAFTVALATVLAKAITVVIAFKAT
                     FPGRIIRWLMISRAPNYTIPICTLIQLVLCGIWMATFPPFVDQDDHTEHGHVIIFCNK
                     GSSVAFHCALGYLCFLALGSYAMAFFSRNLPDTFNESKFLSFSMLVFFCVWITFLPVY
                     HSTKGKIMLAMEVFCILASSAALLGFIFTPKCYIILLRPEKNSFHRIRNKIHSKGNVS
                     QTIVQKPI"
     misc_feature    124..1509
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    124..1509
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(235..237,529..534,1204..1206)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(235..237,529..534,1204..1206)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,490..492,751..753)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,490..492,751..753)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1531..1692
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1531..1692
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1750..2505
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..2505
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1750..1827
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1759..1761,1768..1773,1780..1785,1789..1794,
                     1894..1896,1906..1908,1915..1920,1942..1944,1954..1956)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1861..1926
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1921..1923,1957..1962,1969..1974,1981..1983,
                     2221..2223,2236..2238,2245..2250,2257..2259,2359..2361,
                     2368..2373,2380..2382,2392..2394,2416..2421,2428..2430,
                     2437..2439,2449..2451)
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1951..2025
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2095..2145
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2224..2304
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2326..2397
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2410..2487
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..224
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
     exon            225..519
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1326
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1527
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1651
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..2595
                     /gene="Vom2r11"
                     /gene_synonym="RGD1563778"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagatgt tctcctggat ttttatcacc agctttttgc agactcctta tcttgttttc
       61 acctttaacc tgagtatctg ctattactta atcactgaag attttcatca tgaaggagat
      121 ttgatgattg gtgcattttt tccagttcat acttactaca ccgtgaacaa aattccaaat
      181 gtacaatttc ctaatatata ctattatcaa gactattacc tacagtttaa ttttaagaac
      241 taccagtatg ttttggctct ggaatttgcc attgaggaga tcaataggaa tcccaatctt
      301 ttacccaacc taactcttgg atttgatttc tacaatgtca aattcacaga aaaggaaact
      361 ctaatgaatg tatgtatgtg gcttacagct cacaaaaggg gaaaggtttt acctaattac
      421 aactgcgaag agaaaaattt tactgctgca ttcacaggaa catcatggac aacgtctgca
      481 cacattggga cattgctaca actcttcaga ttcccacagc tttctattgg accttatgat
      541 actgccttga atgatcatgg ccagtattct tcgctctacc agatggccac taaagacaca
      601 tctctctcac atggcattgt ctccttgatg ctttatttta ggtggtcctg ggttggtctc
      661 ctcctcccag atgaccataa agggaataaa gttttatcag agtttaggga tgagatggag
      721 agagaaagag tctgcatagc ttttgtgaaa atgatcccaa ccacctggac tttatatttt
      781 aacaaacaat ggaaaaatat ggaagagatc gaggaatctt cgacaaatgt gataattatt
      841 tatggtgatg ttgattcttt acaaggtctc atgcgaaata ttgggcaaag gttactgaca
      901 gggaaagtat gggtaatgaa ttttgaacag gatattaccg accatgctga ttatttcctg
      961 ttagactcat tccatgggag tttcattttt acacaacatt acggggagag ttttgagttt
     1021 accaagttta ttcaaactgt taatccttac aaatatccag aagacattta tcttcctaaa
     1081 atgtggcatt atttcttcaa gtgctcatat tctgaagttg attgtaaact tttggacaac
     1141 tgtcaagcca atgcaacttt gaatgtatta ccgagacaca tatttgatgt gtccatgagt
     1201 aaggagagct ataatatata caatgctgtg tatgctgtgg ctcacagtct ccatgagatt
     1261 actcttaagc aagtacaaat gcaaccatgc aaaaacggag aagagctgtt gttttatccc
     1321 tggcagatta actctttcct gaggaaaaac atgggattag attggagaca gaaaagaaat
     1381 gaagagtatg atattcttaa tctttggaat tttccaaagg gtcttggact aaagattaaa
     1441 ataggaaagt attcagaaaa tgctcccgat gggcaacagt tgactttatc tgaccagatg
     1501 attcaatggc cagaaaagtt ttcagagatt cctcaatctg tgtgcagtga gagttgtggg
     1561 cctggattca ggaaagtcac cttggagggt caagcagtct gctgctacaa ttgcacacct
     1621 tgcgcagaaa atgagatttc caatgagaca gatgtagatc attgtgtgaa gtgtccagaa
     1681 agttattatg caaatacaga gaagaaccac tgcctccaga aagctcaaag ctttctggcc
     1741 tatgaggacc ccttgggaat ggctctcacc agcatatccc tgttattttc tgccctcaca
     1801 gtcattgttg ttgggatctt tgtaagacac agacacactc caatggtcaa ggctaataat
     1861 cgagctctca gttacacttt gctcatctca ctcaacttct gttttctctg ctctttgaac
     1921 ttcattggcc agcccaacac agccacctgc attctgcagc agacaatatt tggagttgca
     1981 ttcactgtgg ctcttgccac tgtgttagcc aaagcaatca ctgtggtcat tgctttcaag
     2041 gccacttttc cagggagaat aataaggtgg ctaatgatat caagggcccc aaactatacc
     2101 attcctatct gcaccctgat tcaacttgtt ctttgtggaa tatggatggc aacatttcct
     2161 ccatttgttg accaagatga tcatactgaa catgggcatg tcatcatttt ttgcaacaag
     2221 ggctcatctg tagcttttca ctgtgctctg ggatacctct gtttcttggc acttgggagt
     2281 tatgccatgg cctttttctc aaggaatctg ccagatacat tcaatgaatc caaatttctg
     2341 tcattcagca tgctggtgtt cttctgtgtc tggatcacct tcctccctgt ctaccacagc
     2401 actaagggga aaattatgtt ggctatggaa gtcttctgta ttttggcttc cagtgcagca
     2461 ctccttggct tcatatttac ccctaagtgt tacattatat tgttgagacc agaaaaaaac
     2521 tcctttcatc gtattaggaa caaaatacat tctaaaggaa atgtttcaca aaccatagtt
     2581 caaaaaccaa tttag
//
LOCUS       NM_001191832            3777 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus retinol binding protein 3 (Rbp3), mRNA.
ACCESSION   NM_001191832 XM_341400
VERSION     NM_001191832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Li,S., Yang,Z., Hu,J., Gordon,W.C., Bazan,N.G., Haas,A.L., Bok,D.
            and Jin,M.
  TITLE     Secretory defect and cytotoxicity: the potential disease mechanisms
            for the retinitis pigmentosa (RP)-associated interphotoreceptor
            retinoid-binding protein (IRBP)
  JOURNAL   J Biol Chem 288 (16), 11395-11406 (2013)
   PUBMED   23486466
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Garlipp,M.A., Nowak,K.R. and Gonzalez-Fernandez,F.
  TITLE     Cone outer segment extracellular matrix as binding domain for
            interphotoreceptor retinoid-binding protein
  JOURNAL   J Comp Neurol 520 (4), 756-769 (2012)
   PUBMED   21935947
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   Kiser,P.D., Golczak,M., Maeda,A. and Palczewski,K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Suzuki,H., Tsuchiya,K. and Takezaki,N.
  TITLE     A molecular phylogenetic framework for the Ryukyu endemic rodents
            Tokudaia osimensis and Diplothrix legata
  JOURNAL   Mol Phylogenet Evol 15 (1), 15-24 (2000)
   PUBMED   10764531
REFERENCE   7  (bases 1 to 3777)
  AUTHORS   Serizawa,K., Suzuki,H. and Tsuchiya,K.
  TITLE     A phylogenetic view on species radiation in Apodemus inferred from
            variation of nuclear and mitochondrial genes
  JOURNAL   Biochem Genet 38 (1-2), 27-40 (2000)
   PUBMED   10862357
REFERENCE   8  (bases 1 to 3777)
  AUTHORS   Katz,M.L., Gao,C.L. and Stientjes,H.J.
  TITLE     Regulation of the interphotoreceptor retinoid-binding protein
            content of the retina by vitamin A
  JOURNAL   Exp Eye Res 57 (4), 393-401 (1993)
   PUBMED   8282025
REFERENCE   9  (bases 1 to 3777)
  AUTHORS   Gonzalez-Fernandez,F., Van Niel,E., Edmonds,C., Beaver,H.,
            Nickerson,J.M., Garcia-Fernandez,J.M., Campohiaro,P.A. and
            Foster,R.G.
  TITLE     Differential expression of interphotoreceptor retinoid-binding
            protein, opsin, cellular retinaldehyde-binding protein, and basic
            fibroblastic growth factor
  JOURNAL   Exp Eye Res 56 (4), 411-427 (1993)
   PUBMED   7916695
  REMARK    Erratum:[Exp Eye Res 1993 Jul;57(1):127]
REFERENCE   10 (bases 1 to 3777)
  AUTHORS   Gonzalez-Fernandez,F. and Healy,J.I.
  TITLE     Early expression of the gene for interphotoreceptor retinol-binding
            protein during photoreceptor differentiation suggests a critical
            role for the interphotoreceptor matrix in retinal development
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2775-2784 (1990)
   PUBMED   1703544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 17, 2010 this sequence version replaced XM_341400.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1203846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3120              JAXUCZ010000016.1  9273787-9276906
            3121-3311           JAXUCZ010000016.1  9278215-9278405
            3312-3454           JAXUCZ010000016.1  9280378-9280520
            3455-3777           JAXUCZ010000016.1  9281933-9282255
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3777
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="retinol binding protein 3"
                     /db_xref="GeneID:24711"
                     /db_xref="RGD:3545"
     exon            1..3120
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..3777
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="retinol-binding protein 2; interphotoreceptor
                     retinol- binding protein; interphotoreceptor retinoid
                     binding protein; retinol binding protein 3, interstitial"
                     /codon_start=1
                     /product="retinol-binding protein 3 precursor"
                     /protein_id="NP_001178761.1"
                     /db_xref="GeneID:24711"
                     /db_xref="RGD:3545"
                     /translation="MMREWVLVLSTLLCVLAGPTHLFQPSLVLDMAKVLLDNYCFPEN
                     LMGMQAAIEQAMKSHEILGISDPQTLAHVLTVGVQSSLNDPRLFISYEPSTLEAPQQA
                     PALTDLTREELLAQIQRNIRHEVLEDNVGYLRVDDLPGQEVLSELGEFLVSHVWKQLT
                     GTSSLVLDLRHCAGGHVSGIPYVISYLHPGNTVLHVDTIYDRPSNTTTEIWTLPKVLG
                     ERYSADKDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSDF
                     FLTVPVSRSLGPLGGGGQTWEGSGVLPCVGIPAEQALEKALAILTLRRALPGVVLRLQ
                     EALQDYYTLVDRVPGLLHHLASMDYSAVVSEEDLVTKLNAGLQAVSEDPRLLVRATGP
                     RETPSRPETGPNEPPAVTPEVPKEEDARRALVDSVFQVSVLPGNVGYLRFDRFADASV
                     LKTLGPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLVLSYFQGPEAGPVRLFTTY
                     DRRTNITQEHFSHKELLGQRYGNRRGVYLLTSHRTATAAEEFAFLMQSLSWATLVGEI
                     TAGSLLHTCTVPLLDSPEGGLTLTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALERA
                     QEVLDFHRSLGALVEGTGRLLEAHYARPEIAEQARDLLQSKLAQGAYRTAVDLESLAS
                     QLTADLQEVSEDHRLLVFHSPGELVAEEVPLPPPAIPSPEELSYLIEALFKTDVLPGH
                     LGYLRFDAMAELETVKAIGPQLVRLVWQRLVDTAALVVDLRYNPGSYSSAVPLLCSYF
                     FEEEPRQHLYSVFDRATSRVTEIWTLPLVAGQRYGSHKDLYILMSHTSGSAAEAFAHT
                     MQDLQRATVIGEPTAGGALSVGIYQVDNSPLYASMPTQMALSATTGEAWDLAGVEPDI
                     TVPMSEALSTAQDIVALRAKVPTVLQTAGKLVADNYASPELGAKMAAKLSGLQSRYAR
                     VTSEGALAEMLGADLQMLSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEVFEDLIKFS
                     FHTNVFEDNIGYLRFDMFGDCELLIQVSELLVEHIWKKIVHTDALIIDMRFNIGGPTS
                     SISALCSYFFDEAPPVLLDKIYNRPNDSISELWTHSQLTGERYGSKKSVAILTSGVTA
                     GAAEEFTYIMKRLGRALVVGEVTSGGCQPPQTYHVDDTHLYITIPTARSVGATDGSSW
                     EGVGVTPNVVVSSELALTRAKEILQRALRA"
     sig_peptide     73..123
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    151..1026
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    151..1026
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    order(328..330,781..783,961..963)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    order(328..330,781..783,961..963)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    1057..1944
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    1057..1944
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    order(1222..1224,1705..1707,1885..1887)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    order(1222..1224,1705..1707,1885..1887)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    1981..2859
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    1981..2859
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    order(2158..2160,2614..2616,2788..2790)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    order(2158..2160,2614..2616,2788..2790)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    2884..3744
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    2884..3744
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; Region: Peptidase_S41_IRBP; cd07563"
                     /db_xref="CDD:143479"
     misc_feature    order(3055..3057,3511..3513,3685..3687)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     misc_feature    order(3055..3057,3511..3513,3685..3687)
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     exon            3121..3311
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3454
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3777
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggagcagg gccacagtct tgtacacagt caagggagct ctgacccagc agctggggct
       61 ccagggatcc caatgatgag agaatgggtc ctggttttgt ccacactgct atgtgttctg
      121 gctggtccca cgcacctctt ccagccaagc ctggtactgg atatggccaa ggtcctcctg
      181 gataactact gcttccccga gaacctgatg ggaatgcaag cggcgattga gcaggctatg
      241 aagagtcatg agattctggg catctcggac cctcagacgc tggcccatgt gctgacagtt
      301 ggagtccaga gctctttgaa tgacccacgt ctcttcatct cctatgagcc cagtaccctc
      361 gaggcccccc agcaagcacc agcactcacc gacctcaccc gagaagagct gctggcccag
      421 atacagagga acatccgcca tgaggttctt gaggataacg tgggctacct acgagtggat
      481 gatctccctg gacaggaggt actgagtgag ctgggggagt tcctagtgag ccatgtgtgg
      541 aagcagctca cgggcacctc ctccttggtg ctagatctcc gtcactgtgc tggtggtcat
      601 gtctctggga tcccttatgt catctcctac ttgcaccctg ggaacacagt cttgcacgtg
      661 gataccatct acgatcggcc ctccaacacc accacagaga tctggacctt gcctaaggtc
      721 ctgggggaga gatacagtgc agacaaggat gtggtggtcc tcaccagtgg acacactggg
      781 ggagtagccg aggacatcgc ttacatcctc aagcagatgc gcagggccat cgtggtgggt
      841 gagcggacgg aaggtggcgc cctggacctc cagaagctga gaataggtca gtctgacttc
      901 ttccttacag tgcctgtgtc caggtccctg gggcccctag gtggaggcgg ccaaacatgg
      961 gaaggcagcg gggtgctgcc ctgtgtgggg atacctgcag agcaagccct agaaaaggcc
     1021 ctggccatcc tcaccctgcg acgtgccctg ccaggcgttg tcctccgact ccaggaagcc
     1081 ctacaggact attacacatt agtggaccga gtgccgggcc tgctgcacca cctggccagc
     1141 atggactact cggccgtggt ctccgaagag gacctggtga caaagctcaa tgctggtttg
     1201 caggctgtgt cggaggatcc caggctcctg gtgagagcca ccggacccag agaaaccccc
     1261 tcaagacctg agactggccc taacgagcca ccagcagtca cccctgaggt gcctaaggaa
     1321 gaagatgccc ggagggccct agtggattcc gtgtttcagg tgtccgtgct gccgggcaat
     1381 gtgggctacc tgcgctttga cagatttgca gatgcctctg tgctgaagac actgggccct
     1441 tatgtgctgc ggcaggtgtg ggagcccctg caggacacag agcacctcat catggacctg
     1501 cgtcacaacc ctgggggtcc gtcctctgcc gtgcctctgg ttctgtccta ctttcagggt
     1561 ccggaggctg ggcccgtacg gctcttcacc acctatgacc gtcgcaccaa catcacccag
     1621 gagcatttca gccacaagga gctgctaggc caacgatacg gcaaccggcg tggggtgtac
     1681 ctgcttacta gccacaggac tgccacggct gcggaagagt ttgccttcct catgcagtcg
     1741 ctgagctggg ccacgctggt aggggaaatc accgcgggca gcctgctcca cacctgcacg
     1801 gtgccactgc tggactcgcc ggagggtggc ctgacgctca cggtacccgt gctaactttt
     1861 atcgacaacc acggtgaggc ctggctaggg ggtggggtgg tgcctgacgc catcgtgctg
     1921 gctgaggaag ccttagagag agctcaggag gtgctggatt tccatcgcag tctgggtgcc
     1981 ttggtagagg gcaccggtcg cctgctggag gctcactatg cccggccgga gatcgcagag
     2041 caggccagag atctcctgca gtctaagctg gcccaaggag cctaccgcac ggctgtggac
     2101 ttggagtcgc tggcctcaca gctcactgct gaccttcagg aggtgtctga ggaccaccgt
     2161 ctgttggtgt tccacagccc cggtgagctg gtggcggagg aggtccccct gccgccccct
     2221 gccatcccgt ccccagagga actctcctat ctcatagagg ccctgttcaa aacagacgtg
     2281 ctgccaggcc atctgggcta cttgcgtttt gacgccatgg ctgagctgga gacagtaaag
     2341 gccattgggc ctcagctagt gcggctggtg tggcagaggc tggtggacac ggctgcactg
     2401 gtggttgacc tgcgctacaa tcccggcagc tactcctctg ccgttccgct gctctgctcc
     2461 tacttttttg aggaagagcc ccgccagcac ctctactccg tttttgacag ggcgacatcg
     2521 agggtcacag agatatggac cctgccgctg gttgccggtc aacgctacgg ctcccataag
     2581 gatctctaca tcctcatgag ccataccagc ggctctgcag ctgaggcctt tgctcacact
     2641 atgcaggatc tacagcgggc caccgtcata ggagagccca cagctggagg ggcactctcc
     2701 gtgggcatct accaggtgga caatagcccc ttatatgcct ccatgcccac tcagatggcc
     2761 ctgagtgcca ccactggtga ggcctgggac ttggctggtg tggaacccga catcactgtg
     2821 cccatgagcg aggccctttc cacagcccag gacatagtgg ccctgcgtgc caaggtgccc
     2881 acagtcctgc agacagccgg gaaactagtg gccgataact atgcgtcccc tgaactggga
     2941 gccaagatgg ctgccaagct cagcggtctg cagagccgat atgcaagggt gacttcagaa
     3001 ggggccttgg cagagatgct gggggcggac ctgcaaatgc tctctgggga cccacacctg
     3061 aagacggcac acatcccaga agatgccaaa gacagaattc ctggaattgt gcccatgcag
     3121 attccctccc cagaagtctt tgaggacctg atcaaatttt ccttccacac aaatgtattt
     3181 gaggacaaca ttggctacct gaggttcgac atgtttgggg attgtgagct acttatccag
     3241 gtctcagagc tgctggtaga acacatctgg aagaagatcg tgcacactga tgccctcatc
     3301 atcgacatga gatttaacat cggcggcccc acctcctcca tctcagccct gtgctcctac
     3361 ttctttgacg aggcacctcc cgttctgctg gacaagatct acaaccggcc caacgactcg
     3421 atcagcgaac tttggacaca ctcgcagctc acaggtgaac gatatggctc caagaagagt
     3481 gtagccatcc tgaccagcgg tgtgacagcc ggcgccgccg aggaatttac ttacatcatg
     3541 aagaggctgg gccgggccct ggtcgttggt gaagtgacaa gtggaggctg ccagccacca
     3601 cagacctacc acgtggacga cacgcatctc tatatcacca tccccacagc tcgctctgtg
     3661 ggcgccacgg acggcagttc ctgggaaggg gtgggtgtga cacctaatgt agttgtctct
     3721 tcagaattgg ctcttaccag agccaaggag atactccagc gggccctgag ggcgtaa
//
LOCUS       NM_139259                871 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus neurotrophin receptor associated death domain
            (Nradd), mRNA.
ACCESSION   NM_139259
VERSION     NM_139259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Gowrishankar,K., Zeidler,M.G. and Vincenz,C.
  TITLE     Release of a membrane-bound death domain by gamma-secretase
            processing of the p75NTR homolog NRADD
  JOURNAL   J Cell Sci 117 (Pt 18), 4099-4111 (2004)
   PUBMED   15280425
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Wang,X., Shao,Z., Zetoune,F.S., Zeidler,M.G., Gowrishankar,K. and
            Vincenz,C.
  TITLE     NRADD, a novel membrane protein with a death domain involved in
            mediating apoptosis in response to ER stress
  JOURNAL   Cell Death Differ 10 (5), 580-591 (2003)
   PUBMED   12728256
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Frankowski,H., Castro-Obregon,S., del Rio,G., Rao,R.V. and
            Bredesen,D.E.
  TITLE     PLAIDD, a type II death domain protein that interacts with p75
            neurotrophin receptor
  JOURNAL   Neuromolecular Med 1 (3), 153-170 (2002)
   PUBMED   12095158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF497263.1.
            
            On Aug 31, 2012 this sequence version replaced NM_139259.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF497263.1, SRR8487230.65671.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               AF497263.1         5-875
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="neurotrophin receptor associated death domain"
                     /db_xref="GeneID:246143"
                     /db_xref="RGD:708524"
     exon            1..89
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="upstream in-frame stop codon"
     exon            90..221
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="p75-like apoptosis-inducing death domain protein
                     PLAIDD; neurotrophin receptor homolog-2; neurotrophin
                     receptor-alike death domain protein"
                     /codon_start=1
                     /product="death domain-containing membrane protein NRADD"
                     /protein_id="NP_640352.1"
                     /db_xref="GeneID:246143"
                     /db_xref="RGD:708524"
                     /translation="MLHNVSKGVVYSDTALKGQDGDREGMWVGAGGALAPNTSSLFPP
                     EPPGASSNIIPVYCALLATVVLGLLAYVAFKCWRSRKQRQQLAKARTVELGDPDRDQR
                     HGDSSVFVDSPHGLEPCIPSQGPHADLGCRLYLHIPQQQQEEVQRLLILGEPAKGWRG
                     LAGQLGYQAEAVETMACDQDPAYALLRDWAAQEGSGATLRVLEDALTAIGREDVVQVL
                     SSPAEGCSVV"
     misc_feature    194..196
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K5A9.2); glycosylation site"
     misc_feature    293..295
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K5A9.2); glycosylation site"
     misc_feature    326..439
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="Tumor necrosis factor receptor member 16
                     trans-membrane domain; Region: TNFR_16_TM; pfam18422"
                     /db_xref="CDD:436489"
     misc_feature    326..439
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="Tumor necrosis factor receptor member 16
                     trans-membrane domain; Region: TNFR_16_TM; pfam18422"
                     /db_xref="CDD:436489"
     misc_feature    341..403
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K5A9.2);
                     transmembrane region"
     misc_feature    596..850
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="Region: death domain"
     misc_feature    596..841
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="Death domain of p75 Neurotrophin Receptor; Region:
                     Death_p75NR; cd08311"
                     /db_xref="CDD:260025"
     misc_feature    596..841
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="Death domain of p75 Neurotrophin Receptor; Region:
                     Death_p75NR; cd08311"
                     /db_xref="CDD:260025"
     exon            222..411
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            412..554
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            555..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagaccg gaacctgccc tctccaggga ctcccgtcgc cttcctagct gagtggatcc
       61 tagcacccct ggaggggtgg ccgcagaaga gttccttctg gactcagaga agcaggatcc
      121 aggctccatc agctcagttc ccctccacca agaaacagcc cagcgagcag tacctggtgg
      181 cgccatgctt cataacgtca gcaaaggtgt ggtgtattca gatacagccc tgaaggggca
      241 ggatggggac agggaaggaa tgtgggtagg agctggggga gccctagccc ccaatacctc
      301 ctccctattt ccccctgagc ctccaggggc ctcaagcaac atcattcctg tctactgtgc
      361 tctcctagct actgtagtcc ttggtctgct tgcctatgtg gccttcaaat gctggcgctc
      421 acgtaagcaa agacaacagt tggctaaagc gcggactgta gagctggggg accctgaccg
      481 ggaccaaagg catggtgaca gcagtgtctt cgtggattct cctcatggtc tggagccctg
      541 tattcccagc cagggaccac atgcagacct tggctgccga ctttacctgc atattccaca
      601 gcagcagcag gaggaagtcc agaggctctt gatattgggg gaacctgcca agggctggcg
      661 ggggctggca ggccaactgg gctaccaagc tgaagctgtg gaaaccatgg cctgtgacca
      721 ggacccagcc tatgccctgc taagggactg ggctgctcaa gaaggcagtg gagcaaccct
      781 cagagtgcta gaggatgctc tgactgccat aggccgagaa gatgtggtcc aggttttgag
      841 ctcaccagct gagggctgct ctgtggtgtg a
//
LOCUS       NM_001099491            2574 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 17 (Vom2r17), mRNA.
ACCESSION   NM_001099491 XM_001075348
VERSION     NM_001099491.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Aug 18, 2007 this sequence version replaced XM_001075348.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000001.1  72152066-72152262
            198-489             JAXUCZ010000001.1  72154157-72154448
            490-1302            JAXUCZ010000001.1  72154789-72155601
            1303-1530           JAXUCZ010000001.1  72157395-72157622
            1531-1654           JAXUCZ010000001.1  72164646-72164769
            1655-2574           JAXUCZ010000001.1  72166575-72167494
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2574
                     /gene="Vom2r17"
                     /note="vomeronasal 2 receptor, 17"
                     /db_xref="GeneID:690716"
                     /db_xref="RGD:1592248"
     CDS             1..2574
                     /gene="Vom2r17"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 17"
                     /protein_id="NP_001092961.1"
                     /db_xref="GeneID:690716"
                     /db_xref="RGD:1592248"
                     /translation="MLTFILLFFLLNIPLLVASFIYPRCFWSMKKNEYQDRNLGTGCM
                     FFILAVQQPVEKKYFSHISNIQIPTENQKYPLALAFSMNEINNNPDILPNMSLAFKCS
                     EDSCYLESQYNSLFSLALQNHEILPNFICAEDIKCGVVLSGLKWETTVTLHIILNNFM
                     FQQFRQLTYGHFHPALCDHENFPHLYQMASDDTSLALALVSFIIHFSWNWIGLAIPDN
                     DQGTHFLSYLRREMEKNTVCFAFVNIIPVNMNLYMSRAELYYSQIMTSSANVVIIYGD
                     TGSTLAVSFTMWESLGIQRLWVTTSQWDVTPFKKDFTFDNGYGTFGFGHRHSEISGFK
                     YFVQTLNPFKYSDEYLVKLEWMYINCKILENKCKTLKNCSFNHSLEWLMTHTFDMAVI
                     EGSYEIYNAVYAFAHALHEMTLQNVDNLLLDNYKEQNYNCKKVYPFLSKIQFTNPVGD
                     TVNMNQRNKLKEEYDIFYNWNFPQGLGFKVKIGIFSPYFPKGQQLHLRENILEWSTGS
                     IQMPTSVCSADCGPGFRKVWKNGMPACCFDCSPCPENEISNETNVELCVQCPEEQYAN
                     QEQNHCIHKARIFLSYDEPLGMVLSLMALCLAALTVVVLGVFVKHHRTPIVKANNCTL
                     TYILLIALIFCFLCPLFFIGHPNSATCILQQITFGVVFTVAISTVLAKTTTVILAFRI
                     TAPHRMMKYFLISRATNYIIPICTLIQIIVCAIWLGASPPSVDIDAQSEHGHIIIVCN
                     KGSVTAFYCVLGYLACLAFVSFTLAFLSRNLPVTFNEAKSMTFSMLVFCSVWVTFLPV
                     YHSTKGKVMVVVEIFSTLASSAGMLGCIFVPKCYTILCRPDRNSLQMIKEKSSSHTHI
                     L"
     misc_feature    121..1512
                     /gene="Vom2r17"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1512
                     /gene="Vom2r17"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r17"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(208..210,508..513,1180..1182)
                     /gene="Vom2r17"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1534..1695
                     /gene="Vom2r17"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1534..1695
                     /gene="Vom2r17"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1753..2505
                     /gene="Vom2r17"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..2505
                     /gene="Vom2r17"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r17"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1753..1830
                     /gene="Vom2r17"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r17"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1762..1764,1771..1776,1783..1788,1792..1797,
                     1897..1899,1909..1911,1918..1923,1945..1947,1957..1959)
                     /gene="Vom2r17"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r17"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1864..1929
                     /gene="Vom2r17"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r17"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1924..1926,1960..1965,1972..1977,1984..1986,
                     2224..2226,2239..2241,2248..2253,2260..2262,2362..2364,
                     2371..2376,2383..2385,2395..2397,2419..2424,2431..2433,
                     2440..2442,2452..2454)
                     /gene="Vom2r17"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r17"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1954..2028
                     /gene="Vom2r17"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r17"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2098..2148
                     /gene="Vom2r17"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r17"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2227..2307
                     /gene="Vom2r17"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r17"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2329..2400
                     /gene="Vom2r17"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r17"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2413..2490
                     /gene="Vom2r17"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..197
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
     exon            198..489
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1302
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1654
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2574
                     /gene="Vom2r17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcacct tcattttact cttctttctc ctgaacattc cactccttgt ggctagtttt
       61 atttatccca ggtgcttttg gagtatgaag aagaatgaat accaggatag aaacctggga
      121 acaggttgta tgttctttat tctagcagtg caacaacctg tggaaaaaaa gtatttcagt
      181 catatttcga atatacaaat acctactgaa aaccaaaagt atcctctcgc cttggctttt
      241 tccatgaatg aaatcaacaa caaccctgat attttgccaa atatgtcctt agcattcaaa
      301 tgctcagaag acagttgtta tttggaatcc caatacaata gtctcttttc tttggcttta
      361 caaaatcatg aaattctccc taattttatc tgtgcagaag acatcaagtg tggagtggta
      421 cttagcggac taaaatggga aacaacagtg acacttcata taatcctaaa caatttcatg
      481 tttcagcagt tccgtcagct tacttatgga cactttcatc ctgctctgtg tgatcatgaa
      541 aattttcctc atctatatca gatggcctct gatgatacat ctctagccct tgctctcgtc
      601 tccttcataa ttcatttcag ttggaactgg atagggttgg ccatccccga caatgatcaa
      661 ggaacacatt ttctctctta tttgagaaga gagatggaaa aaaatacagt ctgctttgcc
      721 tttgtcaaca ttattccagt caatatgaat ttatacatgt caagagctga attgtattac
      781 agccaaatta tgacatcatc cgcaaatgtt gttatcattt atggtgatac agggagtacg
      841 ttagctgtga gctttacaat gtgggaatct ctaggtatac agagactatg ggtcaccacc
      901 tcacagtggg atgtcactcc ttttaagaaa gacttcacat ttgataatgg atatggaact
      961 tttggctttg gacaccgcca cagtgagatt tctggtttta aatattttgt tcagacattg
     1021 aaccctttca aatactcaga tgaatatttg gtaaagctgg aatggatgta tattaattgt
     1081 aaaatcttag aaaataaatg taagacactg aagaactgct cctttaatca ctcattggaa
     1141 tggctaatga cacatacttt tgatatggcc gttattgaag ggagttatga aatatacaat
     1201 gctgtgtatg cttttgccca tgcactccat gagatgactt tacaaaatgt tgataatctt
     1261 ctccttgaca attataaaga acaaaattat aactgcaaga aggtttatcc ctttctgagc
     1321 aagattcaat tcacaaatcc tgttggagac actgtgaata tgaatcaaag aaacaaactg
     1381 aaggaagagt atgacatttt ctataattgg aattttccac agggacttgg atttaaagta
     1441 aaaataggaa tatttagtcc atattttcca aaaggtcaac agctacactt acgtgaaaat
     1501 attttagagt ggtccacagg aagtatacag atgccaacct ctgtgtgcag tgccgattgt
     1561 ggtcctggat ttagaaaagt ctggaagaat ggaatgccag cctgttgttt tgactgcagt
     1621 ccctgcccag aaaatgaaat ttctaatgag acaaatgtgg aattgtgtgt ccagtgtcca
     1681 gaggaacaat atgctaacca agagcagaat cactgcattc acaaagctcg tatctttctc
     1741 tcttatgatg aacccttggg gatggttctt tccttaatgg ccttatgcct cgctgcactc
     1801 acagttgtgg ttcttggagt ctttgtgaaa catcacagaa ctcccatagt taaggctaat
     1861 aactgcactc tcacctacat cttgctcatc gcactcatct tttgtttcct ctgccccttg
     1921 ttcttcattg gccatccaaa ctcagctacc tgcatccttc agcaaatcac atttggagtt
     1981 gtgttcactg tggctatttc cactgtgttg gccaaaacaa ccactgtcat tctggctttc
     2041 agaatcacag cccctcatag aatgatgaag tactttctta tttcaagggc aactaactac
     2101 atcattccca tttgtactct cattcaaatt attgtatgtg ccatctggct aggagcttct
     2161 cctccttctg ttgatattga tgcacagtct gagcatggtc acatcatcat tgtttgcaac
     2221 aagggttcag tcactgcttt ttactgtgtc ctgggatact tggcctgcct ggcctttgtg
     2281 agcttcacac tggctttcct ttccagaaac cttcctgtca ccttcaatga agccaagtcc
     2341 atgacattca gcatgctggt gttctgcagt gtctgggtca ctttcctacc tgtttaccat
     2401 agcaccaaag gcaaggtcat ggtggttgtg gagatctttt ccaccttggc ttctagtgca
     2461 ggaatgttgg gatgcatttt tgttccaaaa tgttacacaa tactgtgtag accagacaga
     2521 aattctcttc aaatgatcaa ggagaagtca tcttcccaca ctcacatttt ataa
//
LOCUS       NM_001192013            1575 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus NOBOX oogenesis homeobox (Nobox), mRNA.
ACCESSION   NM_001192013 XM_578257
VERSION     NM_001192013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Ferrari,I., Bouilly,J., Beau,I., Guizzardi,F., Ferlin,A.,
            Pollazzon,M., Salerno,M., Binart,N., Persani,L. and Rossetti,R.
  TITLE     Impaired protein stability and nuclear localization of NOBOX
            variants associated with premature ovarian insufficiency
  JOURNAL   Hum Mol Genet 25 (23), 5223-5233 (2016)
   PUBMED   27798098
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Choi,M., Lee,O.H., Jeon,S., Park,M., Lee,D.R., Ko,J.J., Yoon,T.K.,
            Rajkovic,A. and Choi,Y.
  TITLE     The oocyte-specific transcription factor, Nobox, regulates the
            expression of Pad6, a peptidylarginine deiminase in the oocyte
  JOURNAL   FEBS Lett 584 (16), 3629-3634 (2010)
   PUBMED   20659469
  REMARK    Erratum:[FEBS Lett. 2010 Nov 5;584(21):4490]
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Monti,M. and Redi,C.
  TITLE     Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and
            Oogenesin2) are differentially expressed during natural and
            gonadotropin-induced mouse follicular development
  JOURNAL   Mol Reprod Dev 76 (10), 994-1003 (2009)
   PUBMED   19480014
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Choi,Y., Qin,Y., Berger,M.F., Ballow,D.J., Bulyk,M.L. and
            Rajkovic,A.
  TITLE     Microarray analyses of newborn mouse ovaries lacking Nobox
  JOURNAL   Biol Reprod 77 (2), 312-319 (2007)
   PUBMED   17494914
  REMARK    Erratum:[Biol Reprod. 2008 Feb;78(2):378]
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Gazdag,E., Rajkovic,A., Torres-Padilla,M.E. and Tora,L.
  TITLE     Analysis of TATA-binding protein 2 (TBP2) and TBP expression
            suggests different roles for the two proteins in regulation of gene
            expression during oogenesis and early mouse development
  JOURNAL   Reproduction 134 (1), 51-62 (2007)
   PUBMED   17641088
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Choi,Y. and Rajkovic,A.
  TITLE     Characterization of NOBOX DNA binding specificity and its
            regulation of Gdf9 and Pou5f1 promoters
  JOURNAL   J Biol Chem 281 (47), 35747-35756 (2006)
   PUBMED   16997917
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Rajkovic,A., Pangas,S.A., Ballow,D., Suzumori,N. and Matzuk,M.M.
  TITLE     NOBOX deficiency disrupts early folliculogenesis and
            oocyte-specific gene expression
  JOURNAL   Science 305 (5687), 1157-1159 (2004)
   PUBMED   15326356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_578257.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000004.1  73134395-73134431   c
            38-328              JAXUCZ010000004.1  73132350-73132640   c
            329-433             JAXUCZ010000004.1  73132144-73132248   c
            434-540             JAXUCZ010000004.1  73131698-73131804   c
            541-647             JAXUCZ010000004.1  73131281-73131387   c
            648-733             JAXUCZ010000004.1  73130936-73131021   c
            734-965             JAXUCZ010000004.1  73130477-73130708   c
            966-1270            JAXUCZ010000004.1  73129857-73130161   c
            1271-1575           JAXUCZ010000004.1  73128926-73129230   c
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /note="NOBOX oogenesis homeobox"
                     /db_xref="GeneID:502759"
                     /db_xref="RGD:1563929"
     CDS             1..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /codon_start=1
                     /product="homeobox protein NOBOX"
                     /protein_id="NP_001178942.1"
                     /db_xref="GeneID:502759"
                     /db_xref="RGD:1563929"
                     /translation="MEPPEKLCRKMRGQEAGDKPRTAAQDTEGPPQDPAPLVQGDPDK
                     LSSLPRAGLGKRPLSKTSGDCIDADTCRVHTAPSPAVCSPKPQKKGSSLQEKKAETVK
                     PSMSAGPGQVPNPLNFRERDLKKEPLEATCQFRKKTRTLYRSDQLEELERIFQEDHYP
                     DSDKRHEIAQMVGVTPQRIMVWFQNRRAKWRKVEKLNEKEDNNGPAPPRANSSQCRSA
                     PELLGPMPTDLEPGPVPPENILDGFTEPPVLLTSDQTLTSSQHNESAERVAVTPPLLS
                     PPPIRRTNLPLPLGPFQAPQVLPPLRDVPGSDSIYKDKPCGSWGTSITSPPIYSNLED
                     MGPQDYQASNQLGSFQLTQAPQTPLFPPLQSQVPYLPPFPLPIPSPLPFLPPEDSLFS
                     FPFGLNGDSSQDYYPGPQSGQILLQPTAGNTGPGPWSGHCLPEPPFPRPHHPQGHPLG
                     AEGYFPDLFPTPCAPTLSKQPSLGLSGLLGGTRAVTGTSISKMPDEQTSSSLEQPAPE
                     EVRDKNKDSQVGGAKE"
     misc_feature    406..576
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    406..576
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            1..37
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            38..328
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            329..433
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            434..540
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            541..647
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            648..733
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            734..965
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1270
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1575
                     /gene="Nobox"
                     /gene_synonym="RGD1563929"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaacctc cggagaagct ctgtaggaaa atgcggggcc aggaagctgg tgacaagccc
       61 aggactgctg cacaggacac agagggacca ccacaggatc ctgccccact tgtccaaggt
      121 gacccagaca agctgtcctc actccccagg gctggcttgg gaaagaggcc actgtcaaag
      181 acctctgggg attgcattga tgctgacacc tgtagagtgc acacagcccc ctcaccagct
      241 gtgtgtagtc ccaaacccca gaaaaaaggt tcttctctcc aagagaaaaa ggcagagaca
      301 gtgaagccat ccatgtctgc aggcccaggc caagtcccaa atcccctcaa ctttcgagag
      361 agggacctga agaaggaacc cctagaagca acctgtcagt ttcggaaaaa gactcgaacc
      421 ctgtaccgct cagaccagct ggaagagctg gaacggatat tccaggaaga ccactatcct
      481 gacagtgaca aacgccatga gattgcccag atggtggggg tgactcccca acgcatcatg
      541 gtgtggtttc agaaccgtag ggcaaagtgg cgaaaagtag agaaactaaa cgagaaggaa
      601 gataataatg gtcctgcacc cccgagggct aacagcagcc agtgcagatc tgcacctgag
      661 ctcctaggtc ctatgcctac agacctagaa cctggccctg ttcctccaga gaacattctg
      721 gatggcttta ctgagccccc cgtgctgctg acttcggacc agactctaac gtcctctcag
      781 cacaatgaga gtgctgagag ggtggcagtg actccaccac tcctcagtcc cccacctatt
      841 cgaaggacca accttcctct tcctctgggt ccctttcaag ctcctcaagt gctacctccg
      901 ctgagggatg ttcctggcag tgacagcata tacaaggaca agccctgtgg gtcctggggt
      961 actagtatca cctcacctcc catctactca aatttggaag acatgggacc tcaggattac
     1021 caagcaagca accagctggg ttcgttccag ctcacccagg ctccacagac cccccttttc
     1081 ccaccccttc agtcccaggt tccgtatctg cctcccttcc ctctccctat cccaagccca
     1141 ctgccatttc taccaccaga agactctctg ttttcatttc ctttcggcct caatggggac
     1201 tcatcacagg attattaccc agggccccaa tcaggtcaga tcttgctgca gccaacagct
     1261 ggaaacacgg gtccaggacc ctggagcggc cattgtttgc cagaacctcc cttccctcgc
     1321 ccacaccacc cacagggaca ccccctaggg gcagagggct attttcctga cttgtttccc
     1381 actccatgtg ctccaactct gagcaagcag ccttcattag gcctaagtgg gcttctcgga
     1441 ggcactagag cagtgacagg gacctcgata agcaaaatgc cagatgagca gacttcctct
     1501 tcccttgagc agcctgcacc agaggaggtc agagacaaaa ataaggatag ccaagttggt
     1561 ggagctaagg agtaa
//
LOCUS       NM_001037543             624 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf),
            mRNA.
ACCESSION   NM_001037543 XM_341561
VERSION     NM_001037543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Stepanova,P., Srinivasan,V., Lindholm,D. and Voutilainen,M.H.
  TITLE     Cerebral dopamine neurotrophic factor (CDNF) protects against
            quinolinic acid-induced toxicity in in vitro and in vivo models of
            Huntington's disease
  JOURNAL   Sci Rep 10 (1), 19045 (2020)
   PUBMED   33154393
  REMARK    GeneRIF: Cerebral dopamine neurotrophic factor (CDNF) protects
            against quinolinic acid-induced toxicity in in vitro and in vivo
            models of Huntington's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 624)
  AUTHORS   Wang,L., Wang,Z., Xu,X., Zhu,R., Bi,J., Liu,W., Feng,X., Wu,H.,
            Zhang,H., Wu,J., Kong,W., Yu,B. and Yu,X.
  TITLE     Recombinant AAV8-mediated intrastriatal gene delivery of CDNF
            protects rats against methamphetamine neurotoxicity
  JOURNAL   Int J Med Sci 14 (4), 340-347 (2017)
   PUBMED   28553166
  REMARK    GeneRIF: Results demonstrated that CDNF overexpression in the brain
            could attenuate the METH-induced dopamine and tyrosine hydroxylase
            loss in the striatum but could not lower METH-induced hyperthermia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 624)
  AUTHORS   Liu,H., Zhao,C., Zhong,L., Liu,J., Zhang,S., Cheng,B. and Gong,L.
  TITLE     Key subdomains in the C-terminal of cerebral dopamine neurotrophic
            factor regulate the protein secretion
  JOURNAL   Biochem Biophys Res Commun 465 (3), 427-432 (2015)
   PUBMED   26271594
  REMARK    GeneRIF: In all, these findings suggest that helix-7 in the
            C-terminal is important for CDNF secretion, which maybe potential
            affect CDNF function in ER stress.
REFERENCE   4  (bases 1 to 624)
  AUTHORS   Cheng,L., Zhao,H., Zhang,W., Liu,B., Liu,Y., Guo,Y. and Nie,L.
  TITLE     Overexpression of conserved dopamine neurotrophic factor (CDNF) in
            astrocytes alleviates endoplasmic reticulum stress-induced cell
            damage and inflammatory cytokine secretion
  JOURNAL   Biochem Biophys Res Commun 435 (1), 34-39 (2013)
   PUBMED   23624196
  REMARK    GeneRIF: Data show that overexpression of conserved dopamine
            neurotrophic factor (CDNF) in astrocytes alleviated cell damage and
            proinflammatory cytokine secretion, which may represent a promising
            strategy for neuroprotection in the central nervous system (CNS).
REFERENCE   5  (bases 1 to 624)
  AUTHORS   Sun,Z.P., Gong,L., Huang,S.H., Geng,Z., Cheng,L. and Chen,Z.Y.
  TITLE     Intracellular trafficking and secretion of cerebral dopamine
            neurotrophic factor in neurosecretory cells
  JOURNAL   J Neurochem 117 (1), 121-132 (2011)
   PUBMED   21235575
  REMARK    GeneRIF: Disruption of the helix-1 domain of cerebral dopamine
            neurotrophic factor significantly reduces its secretion in
            endoplasmic reticulum.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 1, 2005 this sequence version replaced XM_341561.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ128463.1, FQ121633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000017.1  79637626-79637800   c
            176-303             JAXUCZ010000017.1  79628695-79628822   c
            304-445             JAXUCZ010000017.1  79626994-79627135   c
            446-624             JAXUCZ010000017.1  79623728-79623906   c
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="cerebral dopamine neurotrophic factor"
                     /db_xref="GeneID:361276"
                     /db_xref="RGD:1307600"
     exon            1..175
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET-like protein 1; conserved dopamine
                     neurotrophic factor; arginine-rich protein mutated in
                     early stage tumors-like 1; arginine-rich, mutated in early
                     stage tumors-like 1"
                     /codon_start=1
                     /product="cerebral dopamine neurotrophic factor precursor"
                     /protein_id="NP_001032632.1"
                     /db_xref="GeneID:361276"
                     /db_xref="RGD:1307600"
                     /translation="MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFL
                     NRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRP
                     MSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRA
                     CAEKHDYVNLIKELAPKYVETRPQTEL"
     sig_peptide     61..132
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     133..621
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /product="Cerebral dopamine neurotrophic factor.
                     /id=PRO_0000306860"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5I0.1)"
     misc_feature    166..456
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET, N-terminal; Region: ARMET_N; pfam20145"
                     /db_xref="CDD:466306"
     misc_feature    166..456
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET, N-terminal; Region: ARMET_N; pfam20145"
                     /db_xref="CDD:466306"
     misc_feature    466..594
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET, C-terminal; Region: ARMET_C; pfam10208"
                     /db_xref="CDD:462997"
     misc_feature    466..594
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET, C-terminal; Region: ARMET_C; pfam10208"
                     /db_xref="CDD:462997"
     exon            176..303
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..445
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagaggcaa cctccgctac tgtaagcaag gtgtgggaag ttcccggtcc caggctcagc
       61 atgcggtgca ccagtccggc tgccctggtg actttttgcg ccgggctttg gatctccaac
      121 catgtgctgg cacagggcct ggaggccggt gtgcgatcga gggctgactg tgaagtatgc
      181 aaagagttct taaaccgatt ctacaactcc ttgctaacca gaggaataga cttttctgtg
      241 gataccatag aggaagagct gatcagcttt tgcgcggaca ccaagggaaa agaaaaccgc
      301 ctgtgctatt atctaggagc taccaaagac tcggccacca agatcctagg tgaagtcact
      361 cgtcccatga gtgtacacat gcccacggtg aagatttgtg agaagctgaa gaagatggac
      421 agccagatct gcgagctgaa atatgagaag aaattggact tggaatctgt ggacctgtgg
      481 aaaatgaggg ttgcagagct gaagcagatc cttcacagct ggggggaaga gtgcagggcc
      541 tgcgcggaga agcatgacta cgtgaacctc attaaagaac tggcccccaa atacgtagag
      601 acgcgccccc aaacagagct ctga
//
LOCUS       NM_001191968            2775 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus autophagy related 9B (Atg9b), mRNA.
ACCESSION   NM_001191968 XM_575327
VERSION     NM_001191968.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Wohlgemuth,S.E., Julian,D., Akin,D.E., Fried,J., Toscano,K.,
            Leeuwenburgh,C. and Dunn,W.A. Jr.
  TITLE     Autophagy in the heart and liver during normal aging and calorie
            restriction
  JOURNAL   Rejuvenation Res 10 (3), 281-292 (2007)
   PUBMED   17665967
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Yamada,T., Carson,A.R., Caniggia,I., Umebayashi,K., Yoshimori,T.,
            Nakabayashi,K. and Scherer,S.W.
  TITLE     Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes
            an autophagy-related protein (APG9-like2) highly expressed in
            trophoblast
  JOURNAL   J Biol Chem 280 (18), 18283-18290 (2005)
   PUBMED   15755735
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575327.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               JAXUCZ010000004.1  11678548-11679100
            554-597             JAXUCZ010000004.1  11679222-11679265
            598-662             JAXUCZ010000004.1  11679393-11679457
            663-824             JAXUCZ010000004.1  11679815-11679976
            825-966             JAXUCZ010000004.1  11680570-11680711
            967-1721            JAXUCZ010000004.1  11681906-11682660
            1722-1878           JAXUCZ010000004.1  11682799-11682955
            1879-2058           JAXUCZ010000004.1  11683270-11683449
            2059-2295           JAXUCZ010000004.1  11683847-11684083
            2296-2429           JAXUCZ010000004.1  11684252-11684385
            2430-2526           JAXUCZ010000004.1  11684546-11684642
            2527-2650           JAXUCZ010000004.1  11684878-11685001
            2651-2775           JAXUCZ010000004.1  11685085-11685209
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2775
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /note="autophagy related 9B"
                     /db_xref="GeneID:499973"
                     /db_xref="RGD:1560887"
     CDS             1..2775
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /note="ATG9 autophagy related 9 homolog B"
                     /codon_start=1
                     /product="autophagy-related protein 9B"
                     /protein_id="NP_001178897.1"
                     /db_xref="GeneID:499973"
                     /db_xref="RGD:1560887"
                     /translation="MVRRMGWGGSRRQRGRWGDLGPSSVPLLPMALPLPASPCRGLGG
                     GRISVFSLSPAPRTRSCSSSLFPPTSGSPSLVIQEAGASQPPFNALPTPATPPTQALP
                     TMTHTSASPSWGSHSTPPLASVTPPPSCRCPQDHPGLRIGPLIPEQDYERLEDCDPEG
                     SQDSSSPVHGEDHQPLLHVPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVF
                     QLGQFIFIVTFTTFLLRCVDYNVLFNNQPKNHTRPGPLHSKVTLSDAILPSAQCAEKI
                     HGSPLLVFLLVLAAGFWLFQLLRSVCNLFSYWDIQVFYREALHIPPEELSSVPWAEVQ
                     SRLLELQRSGGLCVQPRPLTELDVHHRILRYTNYQVALANKGLLPARCPLPWGGSAAF
                     LSRGLALNVDLLLFRGPFSLFRGGWELPEAYKRSDLRGVLATRWRRTVLLLAAVNLAL
                     SPLVLAWQVLHAFYSHVELLRREPGAFGARRWSRLARLQLRHFNELPHELRARLGRAY
                     RPATAFLRAAEPPAPLRALLARQLVFFSGALFAALLVLTIYDEDVLAVEHVLTTMTAL
                     GVTATVARSFIPEEQCQGRSSQLLLQAALAHMHYLPEEPGAAGARTSSYWQMSQLLQY
                     RAVSLLEELLSPLLTPLFLLFWFRPRALQIIDFFHHFTVDVAGVGDICSFALMDVKRH
                     GHPQWLSEGQTEASLSQRAEDGKTELSLMRFSLAHPQWQPPGHSSKFLGHLRGRVQQD
                     AAAWGAPSTRSPPTPGVLSDCTSPLPEAFLANLLVSPRPPQRDLSPTAPCPAAATASL
                     LASISRMAQDPSCVSPGGTGGQKLTQLPELVSAEMSLHAIYLHQLHQQQQQEVWGEAS
                     ASSPSRPWSSPSQPGSPDEEKPSWSSDGSSPASSPRQQWGTQRAQNLFPKDFQETTDA
                     QKEPLPGSLH"
     misc_feature    556..2034
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /note="Autophagy protein ATG9; Region: ATG9; pfam04109"
                     /db_xref="CDD:461177"
     misc_feature    556..2034
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /note="Autophagy protein ATG9; Region: ATG9; pfam04109"
                     /db_xref="CDD:461177"
     exon            1..553
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            554..597
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            598..662
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            663..824
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            825..966
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1721
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1878
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2058
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2295
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2429
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2526
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2650
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2775
                     /gene="Atg9b"
                     /gene_synonym="RGD1560887"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgagac gaatggggtg gggggggagc aggaggcagc gggggcggtg gggagacttg
       61 gggcccagct cagtgcctct gctccctatg gcactgccac tgcctgcttc tccgtgtcgg
      121 ggacttgggg gagggaggat ctctgtcttc tctctgtccc ctgcccctcg tacaagaagc
      181 tgctcctctt cattgttccc tcccacctca gggtccccct ccctggtgat tcaggaggca
      241 ggggcttctc agcctccatt caatgcctta cccaccccag ccacaccccc aacacaggcc
      301 cttcccacaa tgacacacac ctctgcttcc ccctcatggg ggtcccactc caccccaccc
      361 ctggcctcgg tcactccccc tccctcctgc cggtgccccc aggaccatcc tgggctgcgg
      421 ataggccctc tgatccctga gcaggattat gaaaggctag aggactgtga ccctgagggg
      481 tctcaagatt cgtcctcgcc cgtccatggg gaggaccacc aacctttgct ccatgtacct
      541 gaagggctcc gtggctcctg gcatcacatc cagaacctgg acagtttctt caccaagatc
      601 tacagctatc accagcggaa cggttttgcc tgtatcctgc tggaggatgt cttccagctg
      661 ggacagttca ttttcattgt cacctttaca accttcctcc ttcgctgcgt ggattacaat
      721 gttctcttca acaaccaacc gaagaaccat acaaggcctg ggccattgca cagcaaagtg
      781 accttgtcag atgccattct accctcagcc cagtgtgcag agaagatcca tggcagtcct
      841 ctgttggtct tcctcctagt cttggctgct ggcttctggc tgtttcagct gctgcgctcg
      901 gtctgcaatc tcttcagcta ctgggacatc caggtgtttt acagggaggc cctgcatatc
      961 cccccagagg agctcagctc ggtaccgtgg gccgaggtgc agtctcgcct cctggagctg
     1021 cagaggagcg gtgggctgtg tgtgcagccg cgaccgctga ccgaactgga tgtccatcac
     1081 cgcatcctgc gctacaccaa ctaccaggtg gcgctggcca acaagggtct gctgcctgcc
     1141 cgttgcccgc tgccctgggg gggcagtgct gccttcctta gtcgcggcct ggcgctcaac
     1201 gtggacttgc tgctcttccg aggtcccttc tctcttttcc gcgggggctg ggagcttccc
     1261 gaagcctaca agcgcagcga cctccggggc gtcctggcca cccgttggcg gcgcacggtg
     1321 ctgctgctgg ccgccgtgaa cttggcgctg agcccgctgg tgctggcttg gcaggtactg
     1381 cacgccttct acagccacgt ggagctgctg cggcgcgagc ccggagcctt cggagcgcgt
     1441 cgctggtccc gcctggcccg cctgcagttg cgccacttta acgagctgcc gcacgagctg
     1501 cgtgcgcgcc tgggccgcgc ctaccggccc gccaccgcct tcctccgtgc agccgagccc
     1561 cccgcgcccc tccgtgcgct gctggcccgc cagctggtct tcttctccgg tgcgctcttt
     1621 gccgcgctgc tagtcctcac catctatgat gaggacgtgt tggccgtgga gcatgtgctc
     1681 actaccatga cggcgctcgg ggtcacagcc actgtggcca ggtccttcat tccagaggag
     1741 caatgtcagg ggcgttcctc ccagcttctg ctgcaggcgg ccctggcaca catgcattac
     1801 ctcccagagg agcctggtgc agcaggtgct cggaccagct cttactggca gatgtcacag
     1861 ctgcttcagt accgagcagt ctccctcctg gaagagctcc tgtctccgct cctgaccccg
     1921 ctgttcctgc tcttctggtt ccgcccccgt gctctgcaga tcattgattt tttccatcac
     1981 ttcactgtgg atgtggctgg tgttggggac atctgttctt ttgccttgat ggatgtgaag
     2041 cgtcatggtc accctcagtg gctttcagag ggacagacag aggcctcact ctctcagcgt
     2101 gcagaggatg gaaagaccga actctccttg atgcggtttt ccctggcaca cccacaatgg
     2161 cagccaccag ggcacagctc taagttcctt ggacaccttc ggggccgggt acaacaagat
     2221 gcagctgcct ggggtgctcc ctcgacacgc agccccccca ctccaggggt gctcagtgac
     2281 tgtacctccc ctctgccaga agccttcctg gccaacctct tggtgagtcc ccgcccaccc
     2341 cagagggacc tgagccccac ggctccctgc cccgccgcag ccacagccag cctccttgct
     2401 tctatttcac gaatggccca ggaccccagc tgtgtgtctc caggaggcac agggggccag
     2461 aagctgaccc agctcccaga gcttgtttct gctgagatga gcctccacgc catttaccta
     2521 catcagcttc atcaacagca gcagcaggaa gtatggggag aggcttcagc ttcctcccca
     2581 tccaggccct ggtccagccc ttcacagcca ggctcaccag atgaggagaa gccgtcttgg
     2641 tcaagtgatg gttccagtcc tgcttccagc ccaagacagc agtggggcac ccagagggcc
     2701 cagaatctgt tcccaaagga tttccaggag accacagacg cccagaagga gcccctacca
     2761 ggctccttgc actga
//
LOCUS       NM_001142944            1356 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 43A (Trim43a), mRNA.
ACCESSION   NM_001142944 XM_001066018 XM_236463
VERSION     NM_001142944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.829612.1,
                                           SRR26360181.1583777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               JAXUCZ010000008.1  98442456-98442863
            409-504             JAXUCZ010000008.1  98443763-98443858
            505-735             JAXUCZ010000008.1  98444413-98444643
            736-758             JAXUCZ010000008.1  98445738-98445760
            759-856             JAXUCZ010000008.1  98446431-98446528
            857-1356            JAXUCZ010000008.1  98448105-98448604
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1356
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="tripartite motif-containing 43A"
                     /db_xref="GeneID:300884"
                     /db_xref="RGD:1561074"
     CDS             1..1356
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /codon_start=1
                     /product="tripartite motif-containing 43-like"
                     /protein_id="NP_001136416.1"
                     /db_xref="GeneID:300884"
                     /db_xref="RGD:1561074"
                     /translation="MESDNLQASQEILTCFICLGIFTDLVLTRCGHPFCRACLLLFSA
                     DTQIPIHCPLCRHPSKPNFRTAIPGKKLISIVRKERIKKYLSSEEHKCMTHKERKTIF
                     CDENRVLLCQLCSKSQEHRGHRHCHIEEAVLKQMEKLLKQMESLLKKIQELQENLEAE
                     KTMTDQWMDYVTLREEMIRTEYRKLYPSLDEEEAQHIECMKNQGNTNLEELRKSEAMM
                     VHKRSQLMKVYQELMTMSQKPYEVLQQGLDDLFRRCELVQLGMPQVMKPELSAHPNAG
                     LTARFSFFKVKIFFQNLIILNCKMSQFFDIRRFTSRPCHQNTSLDSAGSYRASWGAMD
                     FTTGKHYWELDLKDCEHWAVGVCSNVWLSRSHKKIGSSGAFLLVCVKEGNHYSLFTTC
                     PVSHHYIEKPTGRVGVFLDCEGGCMSFLDVAKSSLIHSYHPEAFSLRVRPFFSTVYTR
                     S"
     misc_feature    28..174
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    28..174
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:473075"
     misc_feature    order(43..45,52..54,88..90,94..96,103..105,112..114,
                     154..156,163..165)
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438495"
     misc_feature    order(43..45,52..54,88..90,94..96,103..105,112..114,
                     154..156,163..165)
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438495"
     misc_feature    187..>768
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="exonuclease SbcC; Region: sbcc; TIGR00618"
                     /db_xref="CDD:129705"
     misc_feature    187..>768
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="exonuclease SbcC; Region: sbcc; TIGR00618"
                     /db_xref="CDD:129705"
     misc_feature    256..414
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="B-box-type zinc finger superfamily; Region:
                     Bbox_SF; cl00034"
                     /db_xref="CDD:469587"
     misc_feature    256..414
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="B-box-type zinc finger superfamily; Region:
                     Bbox_SF; cl00034"
                     /db_xref="CDD:469587"
     misc_feature    <1003..1338
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     misc_feature    <1003..1338
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     exon            1..408
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
     exon            409..504
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
     exon            505..735
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
     exon            736..758
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
     exon            759..856
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1356
                     /gene="Trim43a"
                     /gene_synonym="RGD1561074"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtcag ataatttaca agcctcccag gaaatactta cctgcttcat ctgcctgggc
       61 atctttacgg acctagtcct gacaaggtgt ggccacccct tctgcagggc ctgtctcctc
      121 cttttttcag cagacaccca aatccctatc cactgcccgc tgtgtaggca tccatccaaa
      181 ccgaatttca gaactgctat tcctgggaag aagctgatat ctattgtcag gaaagaaagg
      241 atcaagaagt atttgagttc tgaggagcac aagtgcatga cccacaaaga gagaaagacg
      301 atcttctgtg atgagaacag ggttcttctc tgtcagttgt gttctaaatc ccaggagcac
      361 agaggtcaca gacactgcca cattgaagaa gctgttttga agcaaatgga gaaacttcta
      421 aagcaaatgg aatctttatt gaagaagatc caagaacttc aggagaatct agaggcagag
      481 aagacaatga ctgatcagtg gatggactac gtgaccctac gggaggagat gatcaggaca
      541 gagtatagga aactatatcc atcccttgat gaagaagagg cgcaacatat agagtgtatg
      601 aaaaatcaag gcaacactaa tttagaggag ctcaggaaaa gtgaagccat gatggtccac
      661 aagaggagtc aactaatgaa agtgtatcag gagcttatga caatgtccca gaagccatat
      721 gaggtgctgc agcagggttt ggatgacctg tttagaagat gtgagttagt gcagctgggc
      781 atgccgcagg ttatgaaacc agaactcagt gcccatccca atgctgggtt gactgcaagg
      841 ttcagtttct tcaaagtgaa aattttcttt caaaatttaa tcatactcaa ttgcaagatg
      901 agccaatttt ttgatatcag aaggttcact agtagacctt gccatcaaaa cacatccctg
      961 gattcagctg ggtcctatcg tgcttcctgg ggagcaatgg acttcaccac tgggaaacat
     1021 tactgggagc tggatttgaa ggactgtgag cactgggctg taggggtctg cagcaatgtc
     1081 tggttatcga ggagccacaa aaagattgga tctagcggtg catttcttct tgtgtgcgtc
     1141 aaggagggta atcactacag tctcttcact acgtgtccag tatctcacca ctacatagag
     1201 aagccaacag gccgggttgg cgtgttcctt gactgtgagg gtggatgcat gagtttcctg
     1261 gatgtagcca agagttccct catacacagc taccatccag aagctttcag tctcagagtc
     1321 aggccttttt tctccactgt ctacacacga tcatag
//
LOCUS       NM_001099487            2379 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 37 (Vom2r37), mRNA.
ACCESSION   NM_001099487 XM_001074211
VERSION     NM_001099487.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2379)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Aug 19, 2007 this sequence version replaced XM_001074211.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JAXUCZ010000001.1  102403937-102404218
            283-1089            JAXUCZ010000001.1  102404547-102405353
            1090-1317           JAXUCZ010000001.1  102406736-102406963
            1318-1441           JAXUCZ010000001.1  102408326-102408449
            1442-2379           JAXUCZ010000001.1  102454342-102455279
FEATURES             Location/Qualifiers
     source          1..2379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2379
                     /gene="Vom2r37"
                     /note="vomeronasal 2 receptor, 37"
                     /db_xref="GeneID:690356"
                     /db_xref="RGD:1597332"
     exon            1..282
                     /gene="Vom2r37"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2379
                     /gene="Vom2r37"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 37"
                     /protein_id="NP_001092957.1"
                     /db_xref="GeneID:690356"
                     /db_xref="RGD:1597332"
                     /translation="MFAIEEVNRNPHLLHNTTIGYDIYNIPYTEKNILYSALLWHTGI
                     INPLPNCDCGHKRKSPVVLTGPSWSASAHIGTLLQLYKIPQLTFGPFDSTLNDQGTSN
                     SLYQMAPKDTSLSLAIVLLMLHFSWSWVGLMLPDDHRGTQFLSDLRENMESNGICIAF
                     SKMIPGTWNAFSNALWKSMEKIEESSANVIVIYGDIISVEGLIRHIAQLLVTWKVWVL
                     NSSWDVDNHSDYFMVESFHGSLVFSYHHEEMIEFMNFIQTVNPYKYPEDDYLPKFWFL
                     FFKCSFSKFDCQLLENCQLNASLELLPRHIFDPTMSEEGYNIYNAVYAVAYSLHELSL
                     QQIQIQPYINEKGMVFSPWQLLPFLRTTINKSHVKGHTVMDGGRNLDTKYDILNFWNF
                     PSGLGLKVKVGTYSLSSYKDVQFSLCEGMIQWPTRFTKIPQSVCSESCRPGLRKAAQE
                     GKAVCCFDCTPCAENEISNETDMDQCVKCPESHYANAEKNHCLRKSVSFLAYEEPLGM
                     ALTITALGFSVLTAVVLVVFVKHRDTPIVKANNRSLSYILLLTLFICFLSSLLFIGQP
                     RTATCILQQTAFGILFTVALSTVLAKAITVVIAFKATVPARMVRWLMVSRAPNFIIPF
                     CTLIQIIICGIWLVTSPPFIDQDTHAELGHIIIVCNMGSTVAFHTVLGYLCSLALGSY
                     TMAFLSRNLPDTFNEAKFLSFSMQVFFCVWITFLPVYHSTKGKVMVAMEVFSILASSI
                     ALLGLIFAPKCYIILLRTEKNSCPGIRHKKHSKSNIHLNLVKN"
     misc_feature    28..1299
                     /gene="Vom2r37"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    28..1299
                     /gene="Vom2r37"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(115..117,124..126,253..255,514..516)
                     /gene="Vom2r37"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(115..117,124..126,253..255,514..516)
                     /gene="Vom2r37"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1321..1482
                     /gene="Vom2r37"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1321..1482
                     /gene="Vom2r37"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1540..2295
                     /gene="Vom2r37"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1540..2295
                     /gene="Vom2r37"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1540..1617
                     /gene="Vom2r37"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1540..1617
                     /gene="Vom2r37"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1549..1551,1558..1563,1570..1575,1579..1584,
                     1684..1686,1696..1698,1705..1710,1732..1734,1744..1746)
                     /gene="Vom2r37"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1549..1551,1558..1563,1570..1575,1579..1584,
                     1684..1686,1696..1698,1705..1710,1732..1734,1744..1746)
                     /gene="Vom2r37"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1651..1716
                     /gene="Vom2r37"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1651..1716
                     /gene="Vom2r37"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1711..1713,1747..1752,1759..1764,1771..1773,
                     2011..2013,2026..2028,2035..2040,2047..2049,2149..2151,
                     2158..2163,2170..2172,2182..2184,2206..2211,2218..2220,
                     2227..2229,2239..2241)
                     /gene="Vom2r37"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1711..1713,1747..1752,1759..1764,1771..1773,
                     2011..2013,2026..2028,2035..2040,2047..2049,2149..2151,
                     2158..2163,2170..2172,2182..2184,2206..2211,2218..2220,
                     2227..2229,2239..2241)
                     /gene="Vom2r37"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1741..1815
                     /gene="Vom2r37"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1741..1815
                     /gene="Vom2r37"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1885..1935
                     /gene="Vom2r37"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    1885..1935
                     /gene="Vom2r37"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2014..2094
                     /gene="Vom2r37"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2014..2094
                     /gene="Vom2r37"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2116..2187
                     /gene="Vom2r37"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2116..2187
                     /gene="Vom2r37"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2200..2277
                     /gene="Vom2r37"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2200..2277
                     /gene="Vom2r37"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            283..1089
                     /gene="Vom2r37"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1317
                     /gene="Vom2r37"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1441
                     /gene="Vom2r37"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..2379
                     /gene="Vom2r37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaactacc agtttgttct ggccctgatg tttgccattg aggaggtaaa cagaaaccct
       61 catcttctac acaatacaac tattggatat gatatctata atattccata tactgaaaag
      121 aatattcttt atagtgccct tctttggcat acagggataa tcaatcccct tcctaactgt
      181 gactgtggac acaagagaaa gtcacctgtt gtactcacag gaccatcatg gtcagcatct
      241 gcccatattg gaacactgct acaactctac aaaatacctc agctcacttt tgggcctttt
      301 gattctacct tgaatgatca ggggacatct aattccctct atcagatggc tcccaaagac
      361 acatctctat cacttgccat agtccttttg atgcttcatt tcagctggtc ctgggttggt
      421 ctgatgctcc cagatgacca cagaggtact cagtttctat cagacttgag agaaaatatg
      481 gagagcaatg gcatctgcat agcattttcg aaaatgatcc ctggcacatg gaatgcattt
      541 tccaatgcat tatggaaaag tatggagaaa attgaggaat catcagcaaa tgtgatagtt
      601 atttacgggg acatcatttc tgtagaagga ttaattcggc acattgcaca actgttagtt
      661 acatggaaag tttgggtctt gaactcttca tgggatgttg ataaccattc tgattatttt
      721 atggtagagt catttcatgg gagtcttgtt ttttcatacc accatgaaga gatgattgag
      781 ttcatgaatt ttattcaaac agttaatccc tacaaatacc cagaggatga ttatcttcct
      841 aagttttggt ttttgttttt caagtgctcg ttttctaagt ttgactgtca acttttggag
      901 aactgccaac tcaatgcttc tttggaatta ctacccagac acatttttga cccaactatg
      961 agtgaagaag gatacaatat atacaatgct gtgtatgctg tggcctatag tctccatgag
     1021 ctaagtcttc aacaaataca aatacaacca tatatcaatg aaaaaggaat ggtattctcc
     1081 ccctggcagc ttctcccttt cttaaggacc acaataaata aaagtcatgt gaaaggacac
     1141 acagtaatgg atggaggaag aaacttagat acaaagtatg acattcttaa tttttggaat
     1201 tttccaagtg gtcttggatt aaaggtgaaa gtaggaacct attctctaag ttcttacaag
     1261 gatgtacagt tctctttatg tgaagggatg atacagtggc ctacaaggtt tacaaagatt
     1321 cctcagtctg tatgcagtga gagctgtagg cctggactca ggaaagctgc ccaggaaggc
     1381 aaggctgtct gctgctttga ttgtactcct tgtgcagaaa atgagatttc caatgagaca
     1441 gatatggatc agtgtgtgaa gtgcccagaa agtcactatg ccaacgcaga aaagaaccac
     1501 tgcctccgga aatctgtgag ctttttggcc tatgaagagc cactgggaat ggcactcacc
     1561 atcacagcac tgggcttctc tgtgctgaca gctgtggttc ttgttgtctt tgtgaagcac
     1621 agagacacac ccattgtcaa ggctaacaac cggtctctca gctatatcct gctattgaca
     1681 ctcttcatct gtttcctcag ttccttgctc ttcattggac agcccaggac agccacttgc
     1741 atcttgcagc agacagcatt tggaattttg tttactgtgg ctctctccac agtgttggcc
     1801 aaagccatta ctgtggttat tgcattcaag gccactgttc cagctagaat ggtgaggtgg
     1861 ttaatggtat caagagcccc taatttcatc attcccttct gcacactgat ccaaattatt
     1921 atctgtggaa tctggttagt tacctctcca cccttcattg atcaagatac tcatgccgag
     1981 cttggtcaca tcatcattgt gtgcaacatg ggttcaacag ttgccttcca cactgtcctg
     2041 gggtacctct gctccttagc acttgggagc tacaccatgg ccttcttgtc caggaatctg
     2101 cctgacacat tcaatgaagc caagttcctg tcattcagca tgcaggtatt cttctgtgtt
     2161 tggatcacgt tcctccctgt ctatcacagc acaaaaggaa aggtcatggt ggctatggaa
     2221 gtattctcca tcttggcttc cagtatagca ctccttggat tgatttttgc acccaagtgc
     2281 tacattattt tgttaaggac agaaaaaaac tcctgtcctg gtatcaggca caaaaaacat
     2341 tcaaaaagca atatccattt aaatttagtt aaaaattaa
//
LOCUS       NM_001099473            2103 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 35 (Vom2r35), mRNA.
ACCESSION   NM_001099473 XM_001063172 XM_218287
VERSION     NM_001099473.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On or before Aug 19, 2007 this sequence version replaced
            XM_218287.4, XM_001063172.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-801               JAXUCZ010000001.1  82299086-82299886   c
            802-1038            JAXUCZ010000001.1  82289104-82289340   c
            1039-1162           JAXUCZ010000001.1  82286019-82286142   c
            1163-2103           JAXUCZ010000001.1  82282600-82283540   c
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2103
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="vomeronasal 2 receptor, 35"
                     /db_xref="GeneID:292615"
                     /db_xref="RGD:1559147"
     exon            1..801
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2103
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="putative zinc finger protein"
                     /codon_start=1
                     /product="vomeronasal 2 receptor, 35"
                     /protein_id="NP_001092943.1"
                     /db_xref="GeneID:292615"
                     /db_xref="RGD:1559147"
                     /translation="MQKCTARVVLVFLSNSNFQLILHGLLAVPVSGQVWVSKGTLHMA
                     LALTVPGVFQVLQGTFGLLYHSSRAIGFPEFLTHLSPSQTPEDMFIKKFWEFTFDCTW
                     PYQNSTVTEGVQICSGNESLKNKPHPFPEVSKIDAAYTAVYSIAHALHDMVASAHQDG
                     KGTNSQDFHHWQLLHALRKVHFKTPDRSEIMFDANGDLVTKFDIFQGQKNPNGVFHLV
                     HVGMIDPQASSGNKMMIQLKKDLQVSSLNAEITVPPSICSESCLPGFSQVPRLGAPHC
                     CFDCSPCPEGQFADQRDMKRCLLCPKEQYSSNTRDHCLPRTEIFLAFEEPLGFILALM
                     AILLAGLALLVLGVFLKHRDIPVVRANNRTLSYFLLISLSLCSLCSLLFLGRPTVTTC
                     LLRQTTFAVVFTVAVSSVLAKTVTVVLAFRVTKPGSRIQVCLSPGASTSVILIASLIQ
                     TVLCGVWLATSPPFPERDMISEPRHIVIQCQEGSGATFFCVLGFLGFLAVGTFSVAFL
                     ARDLPDVFNETKFLTFSMLLFCSVWTAFLPLYHSARGKSTVAVEIFSILASTDGLLCG
                     IFIPKCYIILLKPEKNTPAWLRQGRCAHQDRQFSMLHRR"
     misc_feature    <286..981
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    <286..981
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="Type 1 periplasmic binding fold superfamily;
                     Region: Periplasmic_Binding_Protein_type1; cl10011"
                     /db_xref="CDD:471960"
     misc_feature    1042..1203
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1042..1203
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1330..2016
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    1330..2016
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    1372..1437
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    1372..1437
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:410628"
     misc_feature    1462..1530
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    1462..1530
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:410628"
     misc_feature    1606..1656
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    1606..1656
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:410628"
     misc_feature    1735..1806
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    1735..1806
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:410628"
     misc_feature    1840..1908
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1840..1908
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:410628"
     misc_feature    1921..1998
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     misc_feature    1921..1998
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:410628"
     exon            802..1038
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1162
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2103
                     /gene="Vom2r35"
                     /gene_synonym="RGD1559147"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagatcagct attcatcttc cctacctagt ctgagtgaca agatccagtt tccgtccttc
       61 cttcggacac tgcctagtga tctcacatcc tgtcatgcag ttactcagct gataattcac
      121 tttcagtggt cctgggtgat cattctggcc caagatgatg actttggaga gcaggccagt
      181 tctctggcca ctcagcagct gagtgcagct ggtgtgtgca ttgagtttca ccttcatgtc
      241 ccttcccaac agaccttggg gaagattgga gagactgtcc agaagatgca gaaatgtaca
      301 gctagggttg ttctggtttt cttaagcaat tcaaatttcc agctcatctt gcatggctta
      361 ctggctgtcc ctgtctcagg tcaggtgtgg gtcagcaaag gcactctgca catggcactt
      421 gctctgaccg ttccaggcgt tttccaagtg ttgcaaggca catttggcct tctgtatcac
      481 agcagcaggg caattggctt ccccgagttc cttactcact tgagccccag ccagacccca
      541 gaagacatgt ttataaagaa gttctgggag ttcacctttg attgtacatg gccataccag
      601 aacagcacag tgacagaggg tgtccagatc tgctcaggca atgagagtct gaagaacaag
      661 cctcatcctt tcccagaagt gagtaaaatt gatgctgctt acacagctgt ctacagcatt
      721 gcccatgcct tgcatgatat ggtagccagt gcgcaccagg atgggaaagg tacaaactcc
      781 caggacttcc atcactggca gctgctccat gcgctccgaa aggtacactt caagactcct
      841 gatcgaagtg agattatgtt tgatgccaat ggagatttgg tgacaaaatt tgatattttt
      901 caagggcaga agaaccccaa tggtgtattt cacttggtcc atgtaggcat gatagaccct
      961 caagcctctt cagggaacaa aatgatgatc caattgaaga aggatctcca agtgagttcc
     1021 ctgaatgcag aaataactgt gcccccctcc atctgcagtg agagctgcct tccagggttt
     1081 agccaagtgc ccagactggg agccccccac tgctgttttg attgcagtcc atgccctgaa
     1141 ggacagtttg cagaccaaag agacatgaag agatgtcttc tgtgtcccaa ggagcagtac
     1201 tcaagcaata ccagagacca ttgcctcccc aggacagaga tcttcctggc ctttgaggaa
     1261 ccattgggat tcatattggc tttgatggca atcttgctgg ctggtctggc tctcctggta
     1321 cttggagttt tcctgaagca tcgagacata cctgtggtca gggccaacaa cagaactctc
     1381 agctacttcc tcctgatctc tctttccctc tgttccctct gttccttgct tttccttggg
     1441 agacccactg tcaccacctg tctcctccgc cagaccacgt ttgctgtggt gttcacagtg
     1501 gctgtctcct ctgttctggc caagactgtc acagtagtcc tggccttcag agtcaccaag
     1561 ccaggaagca ggattcaggt atgcctgagc cctggtgctt caacctcagt catcctcatt
     1621 gcttccttaa tacagactgt tctttgtgga gtgtggttgg ctacctcccc accattccca
     1681 gagagggata tgatctcaga gccccggcac attgtgatcc agtgccagga gggttctggt
     1741 gccaccttct tctgtgttct gggcttctta ggtttcctgg cagtgggtac cttctctgtg
     1801 gcttttctgg ccagggacct accagatgtc ttcaatgaga ccaagttcct cactttcagc
     1861 atgctgctct tctgcagtgt ctggacagcc ttcctgcccc tgtaccacag tgcccgggga
     1921 aagtccactg tggcggtaga gatcttttcc atcctggcct ccactgatgg acttttgtgt
     1981 ggcatcttca tccccaaatg ctacatcatc ttgttgaaac cagaaaagaa tacccctgcc
     2041 tggctaaggc aaggccgctg tgcacatcaa gacaggcagt tttcgatgct ccacagaagg
     2101 tga
//
LOCUS       NM_001191671            2917 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus ER degradation enhancing alpha-mannosidase like
            protein 3 (Edem3), mRNA.
ACCESSION   NM_001191671 XM_222721
VERSION     NM_001191671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Ninagawa,S., Okada,T., Sumitomo,Y., Kamiya,Y., Kato,K.,
            Horimoto,S., Ishikawa,T., Takeda,S., Sakuma,T., Yamamoto,T. and
            Mori,K.
  TITLE     EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first
            mannose trimming step
  JOURNAL   J Cell Biol 206 (3), 347-356 (2014)
   PUBMED   25092655
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Hirao,K., Natsuka,Y., Tamura,T., Wada,I., Morito,D., Natsuka,S.,
            Romero,P., Sleno,B., Tremblay,L.O., Herscovics,A., Nagata,K. and
            Hosokawa,N.
  TITLE     EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic
            reticulum-associated degradation and mannose trimming
  JOURNAL   J Biol Chem 281 (14), 9650-9658 (2006)
   PUBMED   16431915
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Jul 17, 2010 this sequence version replaced XM_222721.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.44613.1,
                                           SRR26643298.51537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000013.1  66408695-66408973
            280-325             JAXUCZ010000013.1  66412834-66412879
            326-426             JAXUCZ010000013.1  66421956-66422056
            427-466             JAXUCZ010000013.1  66422620-66422659
            467-579             JAXUCZ010000013.1  66426437-66426549
            580-733             JAXUCZ010000013.1  66427472-66427625
            734-868             JAXUCZ010000013.1  66433444-66433578
            869-974             JAXUCZ010000013.1  66435092-66435197
            975-1072            JAXUCZ010000013.1  66441729-66441826
            1073-1198           JAXUCZ010000013.1  66444112-66444237
            1199-1282           JAXUCZ010000013.1  66444417-66444500
            1283-1366           JAXUCZ010000013.1  66447373-66447456
            1367-1491           JAXUCZ010000013.1  66448065-66448189
            1492-1657           JAXUCZ010000013.1  66453556-66453721
            1658-1812           JAXUCZ010000013.1  66453955-66454109
            1813-1966           JAXUCZ010000013.1  66455080-66455233
            1967-2158           JAXUCZ010000013.1  66456635-66456826
            2159-2324           JAXUCZ010000013.1  66457417-66457582
            2325-2510           JAXUCZ010000013.1  66460516-66460701
            2511-2917           JAXUCZ010000013.1  66466738-66467144
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="ER degradation enhancing alpha-mannosidase like
                     protein 3"
                     /db_xref="GeneID:289085"
                     /db_xref="RGD:1561496"
     exon            1..279
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /EC_number="3.2.1.113"
                     /note="ER degradation-enhancing alpha-mannosidase-like 3;
                     ER degradation enhancer, mannosidase alpha-like 3"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 3 precursor"
                     /protein_id="NP_001178600.1"
                     /db_xref="GeneID:289085"
                     /db_xref="RGD:1561496"
                     /translation="MSEAGGGRGCGCRVPQRASWSLVAATAALYLMLATTVCTAGAAP
                     MSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALG
                     KFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGH
                     SLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEAR
                     TGTETDTCTACAGTLILEFAALSRFTGATVFEEYARKALDFLWEKRQRSSNLVGVTIN
                     IHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLL
                     DVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTT
                     DFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDV
                     RTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRNI
                     SKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVE
                     ESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSVDAE
                     DGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETR
                     GFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEG
                     SSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRD
                     PEVENEDQPSSENDSQNQSAEQMLPLPQTVGLADQESPGNPLESPSEPPSPADSEEAA
                     GFAPSEQISSPTETQETAGLDGECTDLDNQLQDQPETEEDPSPNVSWGTKAQPMDSIL
                     ADWNEDIEAFEMMEKDEL"
     sig_peptide     119..244
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    296..1615
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="Glycosyl hydrolase family 47; Region:
                     Glyco_hydro_47; pfam01532"
                     /db_xref="CDD:460241"
     misc_feature    296..1615
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="Glycosyl hydrolase family 47; Region:
                     Glyco_hydro_47; pfam01532"
                     /db_xref="CDD:460241"
     misc_feature    2111..2488
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="protease associated domain (PA) domain-containing
                     EDEM3-like proteins. This group contains various PA
                     domain-containing proteins similar to mouse EDEM3
                     (ER-degradation-enhancing mannosidase-like 3 protein).
                     EDEM3 contains a region, similar to Class I...; Region:
                     PA_EDEM3_like; cd02126"
                     /db_xref="CDD:239041"
     misc_feature    2111..2488
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="protease associated domain (PA) domain-containing
                     EDEM3-like proteins. This group contains various PA
                     domain-containing proteins similar to mouse EDEM3
                     (ER-degradation-enhancing mannosidase-like 3 protein).
                     EDEM3 contains a region, similar to Class I...; Region:
                     PA_EDEM3_like; cd02126"
                     /db_xref="CDD:239041"
     misc_feature    2363..2371
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="PA/protease or protease-like domain interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:239041"
     misc_feature    2363..2371
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /note="PA/protease or protease-like domain interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:239041"
     exon            280..325
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            326..426
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            427..466
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            467..579
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            580..733
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            734..868
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            869..974
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1072
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1198
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1282
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1366
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1491
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1657
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1812
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1966
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2158
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2324
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2510
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2917
                     /gene="Edem3"
                     /gene_synonym="RGD1561496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagcctca ccccacagcc ggccctcgac acggctcgca gcctcctcgg cgccgccatc
       61 ccgcgatgtg gcccaccgtg cgggtgtagc agctgcgcgt gcgcggaacc gcggggccat
      121 gagcgaagcc ggcggcggcc ggggctgtgg gtgccgggtc ccccagcgag cgtcatggag
      181 cctggtggca gcgacggccg cgctctatct gatgttggcc acgaccgtgt gcacggcagg
      241 ggccgcgccc atgagtaggg aagagaagca gaagcttgga aatcaagtcc tggaaatgtt
      301 tgatcacgct tacggcaact atatggaaca tgcctaccca gctgatgaac tcatgccttt
      361 aacctgtcga ggtcgtgtca gaggccagga gccaagccgg ggtgacgtgg atgatgcctt
      421 gggaaagttc tccctaacac tgatcgattc tttggacact cttgtggtat taaacaaaac
      481 taaggaattt gaagatgcag tgagaaaagt tttaagggat gttaatctag ataatgatgt
      541 agttgtttca gtctttgaaa caaacatcag agttcttggg ggtcttttgg gtggacactc
      601 gctggcaatc atgctgaagg aaaaagggga atacatgcag tggtataacg acgagcttct
      661 ccaaatggca aagcagctgg gttacaagct ccttccagct ttcaacacta ccagtggcct
      721 tccatatccc aggattaatt taaagtttgg catcagaaaa ccggaagccc ggacgggaac
      781 tgagacggac acctgcacgg cctgtgcagg caccttgatc cttgagtttg ctgcattgag
      841 tcggttcaca ggagctacag tattcgagga atatgcaaga aaagctcttg attttctctg
      901 ggagaaaaga cagcgaagta gcaatttagt aggcgtgact atcaatattc atactggaga
      961 ctgggtgcgc aaagacagtg gagttggagc agggatcgac tcatattatg agtatctgtt
     1021 gaaagcctat gtcttgctcg gagatgacag ttttctggaa agatttaata cacattatga
     1081 tgccataatg aggtatatta gccagccccc tctcctgctc gatgtgcata tccacaaacc
     1141 aatgctcaat gcccggacct ggatggacgc actgcttgcc ttctttccag gtttgcaggt
     1201 tttaaagggt gatattagac ctgctattga aactcatgaa atgttatacc aggtgattaa
     1261 aaaacacaac ttcctaccag aggcatttac tacagatttc agggttcact gggctcagca
     1321 ccctctaagg ccagagtttg cagagagtac ctacttctta tataaggcta caggagaccc
     1381 ttactacctt gaagtaggga aaacacttat tgaaaatttg aataaatacg ctcgagtgcc
     1441 ttgcggattt gctgccatga aggatgttcg cactgggagt catgaggaca gaatggattc
     1501 gttcttcttg gctgaaatgt tcaaatatct gtacctgtta tttgctgata aagaagacat
     1561 tatttttgac atagaagact atatctttac aacagaggct catctgttac ctctttggct
     1621 ttctaccaca aaccgaaaca tctcgaagaa gaacacaacc tcagaataca cagaactgga
     1681 tgatagtaac tttgattgga cttgtccaaa cacgcagatt ctttttccta atgatccatt
     1741 gtatgcccag agcatccgtg aacccttgaa aaacgtggtg gataagagct gtccaagagg
     1801 catcatcaga gtagaggaga gtttcagaag tggagctaag cctcctctga gagccagaga
     1861 ttttatggcc actaaccctg aacatttaga aatcctgaag aagatggggg tgagtttgat
     1921 tcacctcaaa gatgggcgag tccagctggt ccaacatgca atccaagctg cgagttcagt
     1981 tgatgctgag gacgggttgc ggttcatgca ggagatgata gagttgtcca gtcagcaaca
     2041 gaaggagcag cagctgcctc ctcgagctgt acagattatc tcccacccat tttttggcag
     2101 ggtagtctta actgctggac cagctcagtt tgggctggat ctgtctaaac acaaagagac
     2161 aagaggattt gttgcaagca gtaaaccata taatggctgt tcggagctca ctaaccctga
     2221 ggcagtgatg ggaaaaattg ccttgataca aagaggacag tgcatgtttg cagaaaaggc
     2281 tcgaaacatc cagaatgctg gcgccatcgg tggcattgtg attgatgaca atgaggggag
     2341 cagcagtgac acagcccccc tgttccagat ggctggcgac gggaaagaca cagacgacat
     2401 caagatcccc atgctgttcc tgttcagcaa ggaaggcagc atcatcttgg acgccatccg
     2461 tgagcacgag caggtggagg tgctcctttc tgacaaagcg agagaccgag atcctgaggt
     2521 ggaaaatgaa gaccagccgt cttctgaaaa cgactctcag aatcaaagtg cagagcagat
     2581 gctgccactt cctcagacag tcggcttggc tgatcaggag agccctggaa accctctgga
     2641 gtctccctca gagccaccat cgccagcaga cagtgaagag gctgcgggct ttgcgccttc
     2701 tgaacagatc tctagcccca cagagaccca ggagacggca ggtcttgatg gtgagtgcac
     2761 agacttagat aaccagcttc aagatcaacc cgaaaccgag gaagacccca gtccgaacgt
     2821 cagctggggt acgaaggccc agcctatgga ctccatacta gcagactgga atgaagacat
     2881 agaagcattt gaaatgatgg agaaggacga actatga
//
LOCUS       NM_001437189            5888 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 14 open reading frame
            132 (C6h14orf132), mRNA.
ACCESSION   NM_001437189
VERSION     NM_001437189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2432225.1,
                                           SRR26360194.2042210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               JAXUCZ010000006.1  130130749-130131019
            272-5888            JAXUCZ010000006.1  130157537-130163153
FEATURES             Location/Qualifiers
     source          1..5888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5888
                     /gene="C6h14orf132"
                     /note="similar to human chromosome 14 open reading frame
                     132"
                     /db_xref="GeneID:100909954"
                     /db_xref="RGD:6501064"
     exon            1..271
                     /gene="C6h14orf132"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..496
                     /gene="C6h14orf132"
                     /note="uncharacterized protein C14orf132 homolog"
                     /codon_start=1
                     /product="similar to human chromosome 14 open reading
                     frame 132"
                     /protein_id="NP_001424118.1"
                     /db_xref="GeneID:100909954"
                     /db_xref="RGD:6501064"
                     /translation="MDLSFMAAQLPMMGGAFMDSPNEDFSTEYSLFNSPANVHSTSNG
                     HGQLEESPRSSNDAVLLWIAIIATVGNIVVVGVVYAFTF"
     exon            272..5888
                     /gene="C6h14orf132"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccacttgg aggcgtctgg aaccggagcc tggagccagc cagggctgtg agggctttca
       61 gagacgcgcc accacgccgg ggctgctgag gttacgctcg ccggggcccg agggcacctg
      121 ctcgcggttc cgccggctcc ctgataactg tgcgggaggc tggacccgca gcggcgacag
      181 cgacgacagc agcagcgagg actggagcgc aggcagcagc agcagccaca ccagccgtga
      241 caccatggat ctgtctttta tggccgcgca gctgcccatg atgggaggag cattcatgga
      301 ctcacccaat gaggacttca gtaccgagta ctccctgttt aactcccctg ccaatgtcca
      361 ctcgacctcc aatggccacg gccagctcga ggagtctcct cgctcctcca acgatgctgt
      421 tctgctgtgg attgccatca tagccacggt ggggaacatc gtggtagtag gggtggtgta
      481 tgccttcacc ttctgaggcc cagggatgct gaggctctgg ggaagcccct cccactctga
      541 ctccagcttt ctcccagtca ctggagatac ctatgttctc agatggtccc tggaggggca
      601 ggcaccatgc acctgtaatt tcctccaggc agctccggtt tagagcatct ccttgttgtg
      661 gctgatctaa ttcagagcac cttgaaggtg atggctttca gctcctaaaa gcttgacggc
      721 tcgggtcctt cgagcagcag actgaacaat tcttgaagtt tcggtcagtc cagaatgcaa
      781 ggacggtttg aacatcctat tgggttaaaa aaaaaatgaa ggtctggttt cggtgacagt
      841 aaattgtcac tgtatgtctt tttttttttt ctgcaggctg gttgaaccca gttgtgtggg
      901 tgctgggaca agaactttca caagttcgaa ctcccccttt taagtatatg ccccacccct
      961 ttggatactg atggccatgt tgtaaggtca cggaatgttg agaaaattga cttataaatg
     1021 atagtttgtc cccagacact tggtccttgc agaatgcaag tgcatgagaa gacccagaga
     1081 ctggaatgaa ctttctgatc ttcggaggaa aagcagaaga tgtcttcaaa ttttagatgg
     1141 tccgggcagt tagcagtctc tcctctgagg atgagttagc catgtcccct cgtcattgga
     1201 cagatgtcat ggagagaggc ctgatgacag tgtggtcaga tagtgagtca gggctgagtc
     1261 tggcctccat cctagccaag tcctctagtg agcacgtccc caccccgccc cagcagctga
     1321 ggcacagagg gaatcaggag atgttcagtc tgggcattca cgggtcattc tggtgtctgt
     1381 gctgtaaatt ggtttagatg ttgtgccctc cctcgcagat ctgactcccc acacctctca
     1441 atttatccag tgtgcttgca aatgctgtgg cccaggggaa gctgttagca cagagaactg
     1501 gcccaacctt cgttgctaag aagtgggggc ttagagtgtc tcctgagact cccaaagtcc
     1561 tcagcaggca ggatgctgag ctggcactta gctgttgtgt gctggacgtg ggcgttgtgg
     1621 gatgtttgct ctggcttcct gcctaactag caggatccct catcagacct ctgaggcttt
     1681 ccctgtgcca agggtagggc attctcatga gagaacccag gccagccatg ggaacagaag
     1741 tgtgctgtga cctgtatccc agtgctgtct gaattacctc cggggagctg cggctggcca
     1801 tccatccccc taccttatct ccatggagac agcaggttgg gggaggatct gtgcctgctg
     1861 tactaacaga agggacaggg aagctaagga cagcttctac ccttgtaagg tactggcatg
     1921 tcagtgccct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     1981 ctcacacaca cacacacaca cacacacaca cacacacaca cacacaccgc aaattcaaca
     2041 cacccataca acacacagag agagacagag acaagagaga gacagagagg cagagagaga
     2101 gagagagagt cagttatcga catctttcgt gctctcctgg atcagacaga acggtcccat
     2161 tctgtcctcc tgtctccaaa gtttccctat ctgaacttcc tcaccacaaa aaccaacgag
     2221 gagcaaatga cagaccccag ccagagtagc tggagtgagc cccactgtcc ttgctgcctc
     2281 tgctctgctc tgtcttgctc atcagctaaa gaacgaacag gcctgggttc ggtgcttgag
     2341 agctatgagc cggcatggtg ctagattctt atgcacagcc ttcacccttc catcacctca
     2401 cagcagcaag gcccgtgcac agaaagtaac cagaggccca gagaaatgga gtaactttcc
     2461 taaggccaca cagcatagaa gtgaggatct gggactggaa cctgggagtt aggctctccc
     2521 cctccctctc ccttcccccc tccttctccc tcctctccct cttcctctcc ctctccctct
     2581 ccctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctttctct
     2641 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     2701 ctctccagcc ttctaaggcc gatggcaaca ctgaagtaca ttcaatcagg acctgagtca
     2761 ccagaaggtg ttcctcaagc ttgagatggc ctgaaccact cacaggtctc agaccatcag
     2821 aatggggcag tctcagcttt gcctacaccc cagggatatt aatccttccc ctgccattta
     2881 agattgactt cgagtctcca tgtaagtctc caaggagggt ccctgaagta ggatttcttg
     2941 ggtacgtgta taaggagccc ccaaggtatg cgagccccca aggagctgca ctgtaggaag
     3001 gtttcagtga ccggcactga ggtcagattg tgggcctcac ctgcgtggca agttgatcca
     3061 agctgtacag ccccaaagct ctccagagca gaggaggtca tcttcttggg gagccaagcc
     3121 agaaccccat tgtcttctcc ctgggtaagg tggaccccag agcctcctac atttgatagg
     3181 aaggcccttg ccctttatgt atctgcccct tgcaggagtg atgtctttgc caaaatgttc
     3241 cctgtggtca atgaaatcca attggagcaa ctaatgagtc tccttggcta gagaggccac
     3301 tgtccctcct tatgtgcatt tttaggatcc caaggaatgg gaaatgggac aggccagtgc
     3361 cacacggcca gagaggcagc acaccagctt cctgtcctgg ccgggacgcc tgtccactga
     3421 ccaggacctg tgcaggagct agagccacaa tacagctgaa tgtatgctct tggcatgcta
     3481 gtcctctcct gcagaagcat ggccaccctt ttgtatcagt gggtagtaaa atggcttctc
     3541 tctcctgctg cggacagtcc tacttacaag ctcatgtatt tcccaagtca gggccaggga
     3601 ggagcagcca gagactgaat ggcacatgtg cacccatatc aggctctcct agcctctgtc
     3661 ctctatgggt actcagtaca gggtcgggag gagagggtgc tgagcttcag ctgagagccc
     3721 tgaggtgcag ggcacaggct ccagacagag gcggagctcc tctcagaagc caggggagtg
     3781 aaattatgag ctgtctccct gtgcagcctc ctgagatcag agcttgagca agacatgtca
     3841 tgggggaggg agagagggaa ccacacaaac cacagggctc caggcaatgt acatcaccac
     3901 cggcacgaca ttaccctgcc atcagccagg acagatgggg gctatgtatg gactgcgtgt
     3961 cggcctcatt tggcttggct cactgcggct gtcgtctgtg ctttactgat gggaaataaa
     4021 gccgagaggt tgcttcgtgg gtaaagcctg aggacccgag ctcacatcct cagagtccac
     4081 attaaaataa aaccagctct gggggatgaa ggtgggcagg tttggggggt tcgctggcca
     4141 gccacactaa ccaaaaatgt gagctcaggt tccgtgagct gcactggctt ttcttttgtt
     4201 tcttttgggc tttattcttt gtaagtggtg ggtggataaa tgattaagaa ggacctctgg
     4261 tctctaactg aaaccacatg gaaaagtaca tacacttgta cgtgtgtgca cacatgcaca
     4321 cataaacgag atagagtggg aaggaaacac gggtactagg gcttttcaca ggcaaacctg
     4381 agcacagagg tgtccttgtg cctgcctagg ccacatcatt ggaaagacaa ggtctcaacc
     4441 tctccttctt tctgccgatt tctgcctcaa aagctttcag atctgctttt ccactggggc
     4501 taaatcctag cctgtgtgtg tgtgtgtgtt cagcgttcag ggagtgcgtg tgtgctttgg
     4561 ccacaagata cttcagagcc ttgggtctgc ttggagccct ctgtctggtg gagtggcagg
     4621 gagactgtgt ctgcctcctg tgttctttct tgattttatt tttaagactt gcagcctgta
     4681 tacaaccgca tgtggccgag gatagataca tgtcccaccc aaaacaaaat catgcactta
     4741 aaatattgtg aggttttttt tttcttttgt cctctgtaac tcagtcactc agtttggggt
     4801 gagaactttg cggatggtgt cactatgttg aaatgtcaaa gcctaggacc tgagaatcac
     4861 accatttgca gttcaacgta ctgctctgac atcaccaacg gttctgtgtg caggtttgcc
     4921 tcgagggcat ggacacccat cctcacaggg gtttgggggc attgccaggt ggggctgatc
     4981 tgcaggagag cagagtcttg tccccagatc tcccagccag agaattcccg tgattcttca
     5041 attcaggtac ctttgttccc cagggggaac aatttggcaa tgtctggaga tcattcttat
     5101 ctccagttta cagaggagtg cggacgacgt actgcatcta gagagcagag gccagagatg
     5161 ctcacccgca cagaggacag accccgtggc caactactat ccagccccca aatgccaacg
     5221 acgccgaaga tgggaggcta caccagtcat gtgtgagtca gaccacatgt ggatcagagc
     5281 aaatcagagc ggcgagccca atgtcagcta tgggtggagg cgacccgaca atgtggccag
     5341 aacgctgagg ctgagcttgc ctcccaccag tgactgtcca ggacctctga ggcctgcccc
     5401 tcaccagtgc gtctgagaag catgatcggt gaagagattc tcatggggac aggaaggctg
     5461 gggatcagga acagcatcaa accaatccag gtctcctttc tgaccccccc ccagctctcc
     5521 aaaactgtag acacactaac tctttctact ctctaaatcc ttccagaatt cttactcatc
     5581 acctgctgct tgcggactgc agttcttcac gaggagagcg tcagtcaagc ttctgtgttt
     5641 tgtaatgatt ttctagccag cttgtaaatg tgacatgaaa gtatttttac ctttgtgcca
     5701 gtccttgcca cgcaggcacc ctgttctctg tgtgtcactg gcatttactt gcagtggaaa
     5761 ggttctttgc tgatgtaaga gttccatgtg ctctcttgaa ggtgtggtgg taacacctcc
     5821 ctgtgttagc tttcttgcta cggttgtcat tttctattat aattaaacag aaggaaggtt
     5881 taactctg
//
LOCUS       NM_001099476            2598 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 38 (Vom2r38), mRNA.
ACCESSION   NM_001099476 XM_001080246 XM_218549
VERSION     NM_001099476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On or before Aug 19, 2007 this sequence version replaced
            XM_218549.4, XM_001080246.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000001.1  102495159-102495367
            210-501             JAXUCZ010000001.1  102511945-102512236
            502-1308            JAXUCZ010000001.1  102512570-102513376
            1309-1536           JAXUCZ010000001.1  102514747-102514974
            1537-1660           JAXUCZ010000001.1  102516039-102516162
            1661-2598           JAXUCZ010000001.1  102555769-102556706
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2598
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="vomeronasal 2 receptor, 38"
                     /db_xref="GeneID:308551"
                     /db_xref="RGD:1565669"
     CDS             1..2598
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 38 precursor"
                     /protein_id="NP_001092946.1"
                     /db_xref="GeneID:308551"
                     /db_xref="RGD:1565669"
                     /translation="MLWIFTFGFLYIPNFLCALTDNECYVTSKDYFYHEGDVTIGAFF
                     PLHILYTGNKVSHKYEPYNLQDLHIQYKFKNYQFVLALMFAIEEINRNPHLLPNTTLG
                     YDIYNIPYTEKNILYSAFLWHTGIINPLPNCDCGHKRKSPAVLTGPSWSASAHIGTLL
                     QLYKIPQLTFGPFDSILNDQGQFNSLYQMAPKDTSLSLAIVLLMLHFSWSWVGLMLPD
                     DHRGTQFLSDLRENMESNGICIAFLKMIPGTWNAFSNALWKNMEKIEESSANVIVIYG
                     DIISIQGLMRHVAQLLVTWKVWVLNSSWDIDSHSDYFMLESFHGSLIFSHHHEEMIEF
                     MNFIQTVNPYKYPEDNYLPKFWFLFFKCPFSKFDCHLLENCQPNASLELLPRHIFDPT
                     MSEEGYNIYNAVYAVAYSLHEINLQQTQTQPYTNEKGMVFSPWQLLPFLKTTIKKSHV
                     RGHTVMVGGRNLNTKYDILNFWNFPSGLGLKVKVGTYSLSAHQGVHFSLCEEMIQWPT
                     KFTKIPQSVCSESCRPGFRKAAQEGKAVCCFNCTPCAENEISNETDMDQCLKCPESHY
                     ANSEKNHCLRKSVSFLAYEEPLGMALTITALGFSVLTAVVLVVFVKHRDTPIVKANNR
                     SLSYILLLTLFICFLSSLLFIGQPSTATCILQQTAFGILFTVALSTVLAKAITVVIAF
                     KATVPARMVRWLMVSRAPNFIIPFCTLIQIIICGIWLVTSPPFIDQDTHAERGHIIIV
                     CNMGSIVAFHTVLGYLCSLALGSYAMAFLSRNLPDTFNEAKFLSFSMQVFFCVWITFL
                     PVYHSTKGKVMVSMEIFSTLASSIALLGLIFAPKCYIILLRPEKNSCIDIRHKRHSRR
                     NIHLHLVKN"
     sig_peptide     1..54
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    118..1518
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    118..1518
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(220..222,511..516,1186..1188)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(220..222,511..516,1186..1188)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(334..336,343..345,472..474,733..735)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(334..336,343..345,472..474,733..735)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1540..1701
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1540..1701
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1759..2514
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1759..2514
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1759..1836
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1759..1836
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1768..1770,1777..1782,1789..1794,1798..1803,
                     1903..1905,1915..1917,1924..1929,1951..1953,1963..1965)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1768..1770,1777..1782,1789..1794,1798..1803,
                     1903..1905,1915..1917,1924..1929,1951..1953,1963..1965)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1870..1935
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1870..1935
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1930..1932,1966..1971,1978..1983,1990..1992,
                     2230..2232,2245..2247,2254..2259,2266..2268,2368..2370,
                     2377..2382,2389..2391,2401..2403,2425..2430,2437..2439,
                     2446..2448,2458..2460)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1930..1932,1966..1971,1978..1983,1990..1992,
                     2230..2232,2245..2247,2254..2259,2266..2268,2368..2370,
                     2377..2382,2389..2391,2401..2403,2425..2430,2437..2439,
                     2446..2448,2458..2460)
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1960..2034
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1960..2034
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2104..2154
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2104..2154
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2233..2313
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2233..2313
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2335..2406
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2335..2406
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2419..2496
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2419..2496
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..209
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
     exon            210..501
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
     exon            502..1308
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1536
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1660
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..2598
                     /gene="Vom2r38"
                     /gene_synonym="RGD1565669"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctctgga tttttacctt tgggttccta tatattccca attttttgtg tgcccttact
       61 gacaatgaat gctatgtaac aagcaaggat tatttttacc atgaaggaga tgtgacaatt
      121 ggtgcatttt tccctcttca tattttgtac acaggcaaca aagtttctca taaatatgaa
      181 ccatacaatt tacaagatct tcatatacag tataagttta agaactacca gtttgttctg
      241 gccctgatgt ttgccattga ggagatcaac agaaaccctc atcttctacc caatacaact
      301 cttggatatg atatctataa tattccatac actgaaaaga atattcttta tagtgccttt
      361 ctttggcata cagggataat caatcccctt cctaactgtg actgtggaca caagagaaag
      421 tcacctgctg tactcacagg accatcatgg tcagcatctg cccatattgg aacactgcta
      481 caactctaca aaatacctca gctcactttt gggccttttg attctatctt gaatgaccaa
      541 ggtcaattta attcactcta tcagatggct ccaaaggaca catctctgtc acttgccata
      601 gtccttttga tgcttcattt cagctggtcc tgggttgggc tgatgctccc agatgaccac
      661 agaggtactc agtttctatc agacttgaga gaaaatatgg agagcaatgg catctgcata
      721 gcctttttga aaatgatccc tggcacatgg aatgcatttt ccaatgcatt atggaaaaat
      781 atggagaaga ttgaggaatc atcagcaaat gtaatagtta tttatgggga tattatttct
      841 atacaagggt taatgcggca tgttgcacaa ctattagtta catggaaagt ttgggtcttg
      901 aactcttcgt gggatattga tagccattct gattatttta tgttagagtc atttcatgga
      961 agtctcattt tttcacacca ccatgaagag atgattgagt ttatgaattt tattcaaaca
     1021 gttaatccct acaaataccc agaggacaat tatcttccta agttttggtt tttgtttttc
     1081 aagtgtccat tttctaagtt tgactgtcat cttttggaga actgccaacc caatgcttct
     1141 ttggaattac ttcccagaca catttttgac cccactatga gtgaagaggg ctacaatata
     1201 tacaatgctg tgtatgctgt ggcctatagt ctccatgaga taaatcttca acaaacacag
     1261 acacaaccat ataccaatga aaaaggaatg gtattctccc cctggcagct tctccctttc
     1321 ttaaagacca cgataaaaaa aagtcatgtg agaggacaca cagtaatggt tgggggaaga
     1381 aacttaaata caaagtatga cattcttaat ttctggaatt ttccaagtgg tcttggatta
     1441 aaggtgaaag taggaaccta ttctctaagt gctcaccagg gtgtacattt ctctttatgt
     1501 gaagagatga tacaatggcc tacaaagttt acaaagattc ctcagtctgt gtgcagtgag
     1561 agctgtaggc ccggattcag gaaagctgcc caggaaggca aggctgtctg ctgctttaat
     1621 tgtactcctt gtgcagaaaa tgagatttcc aatgagacag atatggatca gtgtctgaag
     1681 tgcccagaaa gtcactatgc caactcagag aagaaccact gcctccggaa atctgtgagc
     1741 tttttggcct atgaagagcc actggggatg gcactcacca tcacagcact gggcttctct
     1801 gtactcacag ctgtggttct tgttgtcttt gtgaagcaca gagacacacc cattgtcaag
     1861 gctaacaacc ggtctctcag ctatatcctg ctattgacac tcttcatctg tttcctcagt
     1921 tccttgcttt tcattggaca gcccagcaca gccacttgca tcttgcagca gacagcattt
     1981 ggaattttgt ttactgtggc tctctccaca gtgttggcca aagccattac agtggttatt
     2041 gcattcaagg ccactgttcc agctagaatg gtgaggtggt taatggtatc aagagcccct
     2101 aatttcatca ttcccttctg cacactgatc caaattatta tctgtggaat ctggttagtt
     2161 acctctccac ccttcattga tcaagatact catgctgagc gtggtcacat catcattgtg
     2221 tgcaacatgg gatcaatagt tgccttccac actgtcctgg ggtatctctg ctccttagca
     2281 cttgggagct acgccatggc cttcttgtcc aggaatctgc ctgacacatt caacgaagcc
     2341 aagttcctgt cattcagcat gcaggtattc ttctgtgttt ggatcacgtt cctccctgtt
     2401 tatcacagca caaagggaaa ggtcatggtg tctatggaaa tattctccac cttggcttcc
     2461 agtatagcac tccttggatt gatttttgca cccaagtgct acattatttt gttaaggcca
     2521 gagaaaaact cctgtattga tatcaggcac aaaagacatt caagaaggaa tatccattta
     2581 catttagtta aaaattaa
//
LOCUS       NM_001108875            1155 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus sarcoglycan zeta (Sgcz), mRNA.
ACCESSION   NM_001108875 XM_001066057 XM_344526
VERSION     NM_001108875.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Wheeler,M.T., Zarnegar,S. and McNally,E.M.
  TITLE     Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is
            reduced in muscular dystrophy
  JOURNAL   Hum Mol Genet 11 (18), 2147-2154 (2002)
   PUBMED   12189167
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 1, 2008 this sequence version replaced NM_001108875.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1268443.1,
                                           SRR26360190.2243250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               JAXUCZ010000016.1  60363718-60363975
            259-453             JAXUCZ010000016.1  61046224-61046418
            454-555             JAXUCZ010000016.1  61258927-61259028
            556-643             JAXUCZ010000016.1  61339315-61339402
            644-766             JAXUCZ010000016.1  61401567-61401689
            767-839             JAXUCZ010000016.1  61423418-61423490
            840-963             JAXUCZ010000016.1  61435653-61435776
            964-1155            JAXUCZ010000016.1  61438441-61438632
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1155
                     /gene="Sgcz"
                     /note="sarcoglycan zeta"
                     /db_xref="GeneID:364605"
                     /db_xref="RGD:1307788"
     exon            1..258
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    208..210
                     /gene="Sgcz"
                     /note="upstream in-frame stop codon"
     CDS             220..1155
                     /gene="Sgcz"
                     /codon_start=1
                     /product="zeta-sarcoglycan"
                     /protein_id="NP_001102345.2"
                     /db_xref="GeneID:364605"
                     /db_xref="RGD:1307788"
                     /translation="MDRSTDLDIQELKMTREQYILATQQNNLPRPENAQLYPVGIYGW
                     RKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLP
                     LYVKEIHSRKDSPLVLQSDRNVTVNARNHMGQLTGQLTVGAEAVEAQCKRFEVRASED
                     GRVLFSADEDEITIGAEKLKVTGTEGAVFGHSVETPHVRAEPSQDLRLESPTRSLIME
                     APRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNADSIRLGNLPIGSFSSSPSSSNSR
                     QTVYELCVCPNGKLYLSPAGVDSTCQSSSSICLWS"
     misc_feature    331..1107
                     /gene="Sgcz"
                     /note="Sarcoglycan complex subunit protein; Region:
                     Sarcoglycan_1; pfam04790"
                     /db_xref="CDD:461428"
     misc_feature    331..1107
                     /gene="Sgcz"
                     /note="Sarcoglycan complex subunit protein; Region:
                     Sarcoglycan_1; pfam04790"
                     /db_xref="CDD:461428"
     exon            259..453
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            454..555
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            556..643
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            644..766
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            767..839
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            840..963
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1155
                     /gene="Sgcz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatctttga agaagtaaaa caaagtgaat tatcattaat atttatttat ttatattatt
       61 tttaaccggt ggaggctgcg agaccacgga gaatgagact gagagaagct gccagggctt
      121 ggaggaggat aaagctgagt ttcagctgga aactaaaaga ctagatcggt tcggggagca
      181 acttggccgg ttcctctcca cttcctttag tttcgctcca tggacagatc cacggacctg
      241 gacatccagg agctcaagat gactcgagaa caatacatac tagccacaca gcagaacaac
      301 ctgccgagac ctgaaaatgc tcaactctat cctgtgggga tttatggatg gcgaaagagg
      361 tgcttatact tctttgtcct actgctgttg gttaccatga tagttaactt agccatgaca
      421 atatggatat tgaaggttat gaatttcact gtggatggta tgggaaatct gagagtcacc
      481 aagaagggaa tccgacttga aggtatatct gagtttctac tgccattgta tgtgaaagaa
      541 attcattccc gaaaggacag tccattggtc ttacagtctg acagaaacgt aacagtgaat
      601 gcaagaaacc acatggggca gctcacggga cagctgacag tcggagctga ggctgttgag
      661 gcccagtgta aaagatttga agtgagagcc agtgaagacg gcagggtgct gttttctgca
      721 gatgaagatg agatcactat tggggctgag aagctaaagg ttacagggac tgaaggagca
      781 gtatttgggc actctgtgga aacacctcac gtcagagcag agccatctca agacctcagg
      841 cttgaatcac ctaccagatc cttgataatg gaggctccac gtggggtcca ggtgagtgct
      901 gctgcaggtg acttcaaggc tacctgcagg aaggagctgc atttacagtc cacagaagga
      961 gagatttttc taaatgcaga ttcaatccgg ctgggaaatc taccaatcgg ttccttctct
     1021 tcttcaccca gctcttcaaa ttctcgacag acagtgtatg aactgtgcgt ctgccccaat
     1081 ggcaaactct acctttctcc ggctggggta gactccacct gtcagtccag tagtagcatt
     1141 tgcttgtgga gctga
//
LOCUS       NM_001191729            2018 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 120 (Ccdc120),
            mRNA.
ACCESSION   NM_001191729 XM_228761
VERSION     NM_001191729.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_228761.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211363.1, SRR26643298.31208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000021.1  17437219-17437308
            91-224              JAXUCZ010000021.1  17437459-17437592
            225-365             JAXUCZ010000021.1  17438679-17438819
            366-651             JAXUCZ010000021.1  17439170-17439455
            652-714             JAXUCZ010000021.1  17440327-17440389
            715-889             JAXUCZ010000021.1  17440746-17440920
            890-988             JAXUCZ010000021.1  17441051-17441149
            989-1903            JAXUCZ010000021.1  17442202-17443116
            1904-2018           JAXUCZ010000021.1  17443602-17443716
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..2018
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /note="coiled-coil domain containing 120"
                     /db_xref="GeneID:317377"
                     /db_xref="RGD:1561596"
     exon            1..90
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2018
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 120"
                     /protein_id="NP_001178658.1"
                     /db_xref="GeneID:317377"
                     /db_xref="RGD:1561596"
                     /translation="MEVKGQLINSPTFNAPAALFGEAAPQVKSDRLRGLLDRQQALQE
                     TLRLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHSNPAHH
                     SLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHEL
                     EEQLRDFRARLGLPVLQPLPLSSGAPVNAQGVCLGTRLAQLSQEDVVLHSESSSLSES
                     GASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRN
                     SVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHPRQWSGSQDSQMG
                     FPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSE
                     VLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGPPRLPPVCGDFLLDYSLDRGL
                     PRGSGGAGWGDLLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNSRAI
                     RSKPCGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGL
                     AVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYT
                     DFLYPPELSARLSDLTLEGEQSSSSDTQTPGTLV"
     misc_feature    45..416
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /note="Cytohesin Ubiquitin Protein Inducing Domain;
                     Region: CUPID; pfam11819"
                     /db_xref="CDD:463360"
     misc_feature    45..416
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /note="Cytohesin Ubiquitin Protein Inducing Domain;
                     Region: CUPID; pfam11819"
                     /db_xref="CDD:463360"
     exon            91..224
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            225..365
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            366..651
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            652..714
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            715..889
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            890..988
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1903
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2018
                     /gene="Ccdc120"
                     /gene_synonym="RGD1561596"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttatccag ccctcagcca caaggtccaa acagtgcaag gatggaagtc aaaggtcagc
       61 tgatcaactc tcctaccttc aatgctccag ctgccctgtt tggagaggct gccccacagg
      121 tgaagtcaga ccgtcttcga gggctgcttg accgccagca ggccctgcaa gagaccctga
      181 gactgaaact tcaagagctc aggaaagtgt gcctgcagga ggcggagcta actggtcagc
      241 tgccccctga gtgcccactg gagcctggtg aacgacctca gttggtccgc cggaggcctc
      301 ctgcagcacg tgcctaccct ccaccacact caaacccagc acaccactcc ttgtgtcctg
      361 ctgaggaact ggctcttgag gccctggagc gtgaggtatc agtacagcag cagattgcag
      421 ccgctgcccg ccgcctggcc ctggcccctg acctcaacgg agaacagagg cggcgcaggc
      481 gccaggtaca ggtcgatgct ctgcgaaggc tgcatgagct ggaggagcag ctcagggact
      541 tccgggcccg ccttggcctc ccggtgctcc agccactgcc actgtcttcg ggagcaccag
      601 tcaatgccca gggtgtctgc ctgggtacac gccttgctca gctcagccaa gaggatgtag
      661 ttctgcactc ggagagcagc tccctctcag agtcaggtgc cagccatgat aatgaagagc
      721 ctcatagctg cttccctcta acggagcgcc cctccccacc aaaagcctgg gaccagtttc
      781 gggcggtatc tggggggagc cccgagcgac gtgccccatg gaaacctccg ccatcagata
      841 tttatgggga cctgaagagc cggcgcaact ctgtggccag ccccaccagc cccacacgct
      901 cgctgcccag gagtgcctcc agttttgagg ggcgaagtgt gcctgctacc cctgtcctca
      961 cccggggcag tggcccccgg ctctgcaaac ccgaaggcct ccatcctcgt cagtggtccg
     1021 gtagtcagga ctcccagatg ggctttcctc ggcctgaccc tgcttcggat cgggcctctc
     1081 tcttcgcagc tcgtacgcgc cgcagcaata gctctgaggc cctgctggtg gaccgtgcag
     1141 ctgctggggg agctggatca ccacctgctc cgctggctcc ccctgctgct ggtcccccag
     1201 tttgcaagag cagtgaggtg ctgtatgagc gcccccaacc agtcccttct ttctcttccc
     1261 gtaccactgg ccccccagac cctcctcggg ctgccagacc tagctcggct gcccctgcat
     1321 cccgtgggcc cccccggctc ccacctgtgt gtggagactt cctcttggac tactcattgg
     1381 accgaggctt gccccgcggt agtggcgggg ccggttgggg ggacctgctg cctgctcctg
     1441 aagttccagg acccctttcc cgcagagacg ggctccttgc catgctccca ggtcctccac
     1501 ccatatatgc agctgatggt agcagccccc tcctccgcag caaggacccc aacagccgtg
     1561 ccatccgttc caagccctgt ggcttgcccc cagaagccgt ggagggtctg gaagtgcatc
     1621 caaacccatt actctggatg cccccaccca cccggatacc tccagctggt gagcgaggtg
     1681 gccacaagaa ccttgccctg gaggggctgc gggactggta catccggaac tcgggactgg
     1741 ccgttggtcc ccagcgccgg ccaatgctcc cgcacgtggg gccaacacac acacccttcc
     1801 tccatgcccg ctgctatgag gtgggccagt cattgtacgg ccctcccagc caggcaccgc
     1861 tcccgcactc caggagtttt acagcgcccc ctgtctctgg cagatactac acggatttcc
     1921 tgtatccccc ggagctgagc gctcgtttaa gtgacctgac gctagagggg gagcagtctt
     1981 ccagttctga tacccagacc ccagggacac tggtctga
//
LOCUS       NM_001169149            3012 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus NLR family, pyrin domain containing 9 (Nlrp9),
            mRNA.
ACCESSION   NM_001169149 XM_001072936 XM_218248
VERSION     NM_001169149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Zhu,S., Ding,S., Wang,P., Wei,Z., Pan,W., Palm,N.W., Yang,Y.,
            Yu,H., Li,H.B., Wang,G., Lei,X., de Zoete,M.R., Zhao,J., Zheng,Y.,
            Chen,H., Zhao,Y., Jurado,K.A., Feng,N., Shan,L., Kluger,Y., Lu,J.,
            Abraham,C., Fikrig,E., Greenberg,H.B. and Flavell,R.A.
  TITLE     Nlrp9b inflammasome restricts rotavirus infection in intestinal
            epithelial cells
  JOURNAL   Nature 546 (7660), 667-670 (2017)
   PUBMED   28636595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_218248.3, XM_001072936.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.848.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               JAXUCZ010000001.1  77370096-77370366   c
            272-1850            JAXUCZ010000001.1  77356931-77358509   c
            1851-2015           JAXUCZ010000001.1  77352575-77352739   c
            2016-2180           JAXUCZ010000001.1  77351441-77351605   c
            2181-2348           JAXUCZ010000001.1  77339916-77340083   c
            2349-2519           JAXUCZ010000001.1  77336726-77336896   c
            2520-2690           JAXUCZ010000001.1  77324424-77324594   c
            2691-2861           JAXUCZ010000001.1  77323697-77323867   c
            2862-3012           JAXUCZ010000001.1  77320034-77320184   c
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3012
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NLR family, pyrin domain containing 9"
                     /db_xref="GeneID:292577"
                     /db_xref="RGD:1308981"
     CDS             1..3012
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NACHT, LRR and PYD containing protein 9b; NLR
                     family, pyrin domain containing 9B; NACHT, LRR and PYD
                     containing protein 9a"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 9"
                     /protein_id="NP_001162620.1"
                     /db_xref="GeneID:292577"
                     /db_xref="RGD:1308981"
                     /translation="MVDTSGYGLLKHLRKLSDGEFWSFKELLRKEPEKFKLKPISWMK
                     IENASKEELVMLLNTHYPKQAWDMALSLFLQVNREDLSIMAQKKRRYKQTKYKKFMKT
                     TFQSIWTLESNICIPDRSYHLIVEHQYRKLQNIFDSESEPVTAVVTGPTGEGKTVFLR
                     KAMLDWASGILWQNRFQYVFFFSVLSLNNTTELSLAELISSKLPESSETLNDILSDPK
                     KILFILDGFDYLKFDLELRTNLCNDWRKILPTQIILSSLLQKIMLPESSLLLELGHIS
                     LPKIFPLLQYPRDITIQGFSERCLKTYFISFFNTEKGIEVFENLKSNQMLKLCSNPYL
                     CWMFCSCLKWQFDREEEAYFQAKTDSVFFTSFMVSAFKSAYASNPPKQNRAQLKSLCT
                     LAVEGMWKQLFVFDSEDLRRNGISESDKAVWLRMKFLQNHDNHIVFYHPTLQLYFASM
                     FYFLKQDKDTHVPVIGSIPQLLRKIYARDHTQWLQIGIFLFGLATEQVASLLKPYFGF
                     IQHRDVRQEVMRYLKSLSQRECCEKLERPQNLFACLRDNKEEKFVREVVDLFEEITVD
                     ITNSHVLSIIANHLQKSSKLKKLHLHIQKRVFLEIHDPEYSDSETFTQDKKNAAEYWK
                     KLCHIFVNLHVLDLDSCNFNKQVIEELCNVLSPSPKIPLMAFKLESLLCSFMTNFGDG
                     SLFHTLLQLPHLKYLNLYGTNLSNSRIENLCSALRRSTCKVEELLLGKCDISSEACGI
                     IATSLMNSKVKHLSLVENPLKNKGVMSLCEMLKDPSCVLETLMLSYCCLTFIACGHLY
                     EALVSNKHLSLLDLGSNFLEDTGVNLLCEALKDPNCILKELWLSGCFLTSECCEEISA
                     VLTCNNNLKTLKLGNNDIEDTGVKHLCEALSHPNCKLECLGLDLCKFTSDCCEDLASA
                     LTTCKTLNSLNLDWKTLEHSGVVALCEALNHKKCNLKMLGLDKSAFSVESQTLLQAVE
                     KKNNNLSILHYPWVEEERKKRGVRLVWNSKN"
     misc_feature    25..270
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    25..270
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    430..924
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    430..924
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    1153..>1290
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:465501"
     misc_feature    1153..>1290
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:465501"
     misc_feature    1318..1665
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:465499"
     misc_feature    1318..1665
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:465499"
     misc_feature    1897..2001
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    1897..2001
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2002..2061
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2002..2061
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2071..2868
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    2071..2868
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     Region: PPP1R42; cl42388"
                     /db_xref="CDD:455733"
     misc_feature    order(2080..2082,2089..2091,2095..2097,2104..2106,
                     2110..2112,2167..2169,2176..2178,2182..2184,2191..2193,
                     2197..2199,2248..2250,2257..2259,2263..2265,2272..2274,
                     2278..2280,2335..2337,2344..2346,2350..2352,2359..2361,
                     2365..2367,2419..2421,2428..2430,2434..2436,2443..2445,
                     2449..2451,2506..2508,2515..2517,2521..2523,2530..2532,
                     2536..2538,2590..2592,2599..2601,2605..2607,2614..2616,
                     2620..2622,2677..2679,2686..2688,2692..2694,2701..2703,
                     2707..2709,2761..2763,2770..2772,2776..2778,2785..2787,
                     2791..2793,2848..2850,2857..2859,2863..2865)
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    order(2080..2082,2089..2091,2095..2097,2104..2106,
                     2110..2112,2167..2169,2176..2178,2182..2184,2191..2193,
                     2197..2199,2248..2250,2257..2259,2263..2265,2272..2274,
                     2278..2280,2335..2337,2344..2346,2350..2352,2359..2361,
                     2365..2367,2419..2421,2428..2430,2434..2436,2443..2445,
                     2449..2451,2506..2508,2515..2517,2521..2523,2530..2532,
                     2536..2538,2590..2592,2599..2601,2605..2607,2614..2616,
                     2620..2622,2677..2679,2686..2688,2692..2694,2701..2703,
                     2707..2709,2761..2763,2770..2772,2776..2778,2785..2787,
                     2791..2793,2848..2850,2857..2859,2863..2865)
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2080..2166
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2080..2166
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2098..2103,2188..2190,2356..2358,2440..2442,
                     2611..2613,2689..2691,2695..2697,2773..2775,2860..2862)
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    order(2098..2103,2188..2190,2356..2358,2440..2442,
                     2611..2613,2689..2691,2695..2697,2773..2775,2860..2862)
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2167..2247
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2167..2247
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2248..2334
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2248..2334
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2335..2418
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2335..2418
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2419..2502
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2419..2502
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2506..2589
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2506..2589
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2677..2760
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2677..2760
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2761..2847
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     misc_feature    2761..2847
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
     exon            1..271
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            272..1850
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2015
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2180
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2348
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2519
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2690
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2861
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3012
                     /gene="Nlrp9"
                     /gene_synonym="Nalp9a; Nalp9b; Nlrp9b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtggaca cgtctggata tggcttgctg aagcatctgc gaaaactgag tgacggggag
       61 ttctggagct ttaaagagct tctcaggaaa gagccagaga aatttaagct caaaccaata
      121 tcctggatga aaattgagaa tgcttccaaa gaagaactgg taatgctatt gaacacacat
      181 tatccaaaac aggcatggga tatggcgttg agcctgtttc tacaggtcaa tcgggaagac
      241 ctctcaatca tggctcagaa aaagaggaga tataaacaaa ctaaatataa aaagtttatg
      301 aagactacat ttcaaagcat atggacattg gagagcaaca tttgtatacc tgatagaagc
      361 taccatttaa ttgtagaaca ccagtacaga aaactgcaga acatatttga ttctgaatca
      421 gagccagtca ctgcagttgt aacaggtcca acaggagaag gaaaaaccgt tttcctgaga
      481 aaagcaatgt tggattgggc atcaggaatt ttatggcaga accggtttca atatgttttc
      541 tttttctctg tcctctcact taacaatacc acagagttaa gcttagctga gcttatctca
      601 agtaagttac ctgagtcttc agagacactg aatgacattt tatctgatcc aaagaaaatc
      661 ttgtttatcc tggatggatt tgattacctg aaatttgact tggaactcag gacaaacttg
      721 tgtaatgact ggaggaagat attgccaaca caaatcatct tgagtagttt actacagaaa
      781 ataatgctcc cagaatcctc tttgcttctt gaattaggac atataagttt accaaaaatc
      841 ttccctttgc tgcagtatcc aagggacata actatccaag gattctctga gcggtgtcta
      901 aagacctatt ttatatcctt cttcaatact gaaaaaggca tagaagtctt tgagaatttg
      961 aagtctaatc aaatgctcaa attatgcagc aatccttatc tatgctggat gttctgtagt
     1021 tgtttaaagt ggcagtttga cagggaagag gaagcgtact ttcaggctaa aacagattcg
     1081 gtcttcttca caagctttat ggttagtgca ttcaaatcag catatgccag taatccacct
     1141 aaacaaaaca gagcccaatt aaagagcctg tgtaccttgg ctgtagaagg aatgtggaaa
     1201 cagttgtttg tttttgactc tgaagatctc aggaggaatg gtatatctga atcagataag
     1261 gcagtgtggc tgagaatgaa atttctccag aatcatgata accacattgt gttttatcat
     1321 cctacactac agttatactt tgcttccatg ttctatttcc tcaaacaaga caaagacacg
     1381 catgtcccag tcattggaag catacctcaa ctcctaagaa aaatttatgc tcgtgaccac
     1441 acacaatggc tccagatagg gatttttttg tttggactcg ccactgagca agttgcctcc
     1501 ttgctcaaac catactttgg ctttatacag cacagagatg taagacagga agtcatgaga
     1561 taccttaaga gtctcagtca acgagagtgc tgtgagaaat tggaaagacc ccagaatttg
     1621 tttgcctgtc tacgtgacaa caaggaggaa aaatttgtaa gagaagtggt agatctattt
     1681 gaagaaatta ctgttgatat tactaattca catgtattgt caataattgc aaaccatctt
     1741 cagaaatcct ccaaattaaa gaaacttcac ctgcatatac aaaagagagt ttttttagaa
     1801 attcatgacc cagaatatag tgactcagaa acctttacac aggacaaaaa aaatgcagct
     1861 gaatattgga agaagttatg tcatattttt gtcaacttac atgtgttgga tctggacagc
     1921 tgtaatttca acaaacaggt catagaggaa ctctgtaatg tgctgtctcc atcacctaag
     1981 atacctctga tggcttttaa gctcgaaagc ttgttgtgtt cattcatgac taactttgga
     2041 gatggttcac tatttcacac ccttcttcag ctacctcacc tgaaatacct aaacctgtat
     2101 ggcaccaacc tctccaacag taggattgag aatctgtgct ctgctctgag acgctcaaca
     2161 tgcaaagtag aggaactact gttgggtaaa tgtgacatat caagtgaggc atgtggcata
     2221 attgctactt cccttatgaa ctctaaagtg aaacatctct cattggttga aaatcccttg
     2281 aagaacaaag gagtgatgtc actgtgtgaa atgctgaagg atccaagctg tgtccttgag
     2341 acactgatgt tgtcttactg ctgtctcaca ttcattgcct gtggccatct ctatgaagcc
     2401 cttgtgagca ataaacacct ctccctgctt gatctggggt caaatttcct ggaagatact
     2461 ggagtgaacc ttctgtgtga agctttgaaa gacccaaact gcatcctcaa ggagttatgg
     2521 ttgtcaggtt gctttttaac ttcagaatgc tgtgaggaga tctctgctgt cctgacttgc
     2581 aataataatc taaagaccct gaaactgggc aacaatgaca tagaagacac tggtgtcaaa
     2641 catttatgtg aagccctgag tcatcctaac tgtaaattag aatgtcttgg gttagacctg
     2701 tgcaagttca caagtgactg ttgtgaagac ctggcctcag ctctcaccac ctgcaaaaca
     2761 ctgaatagct taaatctgga ctggaaaacc ttggaacact ctggagtcgt ggctctctgt
     2821 gaggctttga atcacaagaa atgtaacttg aagatgcttg gactggacaa atctgcattt
     2881 tctgtggaat cgcagacatt actgcaagct gtggaaaaga aaaacaataa tctgagtatt
     2941 ttacattatc cctgggttga agaggaacgc aagaagaggg gtgttcgtct ggtctggaac
     3001 agcaagaatt ga
//
LOCUS       NM_001191750            2610 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus interleukin 12 receptor subunit beta 2 (Il12rb2),
            mRNA.
ACCESSION   NM_001191750 XM_231873
VERSION     NM_001191750.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Watanabe,T., Kitani,A., Murray,P.J. and Strober,W.
  TITLE     NOD2 is a negative regulator of Toll-like receptor 2-mediated T
            helper type 1 responses
  JOURNAL   Nat Immunol 5 (8), 800-808 (2004)
   PUBMED   15220916
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Gillespie,K.M., Szeto,C.C., Betin,V.M. and Mathieson,P.W.
  TITLE     Role of beta1 and beta2 subunits of the interleukin-12 receptor in
            determining T helper 1/T helper 2 responses in vivo in the rat
  JOURNAL   Immunology 99 (1), 109-112 (2000)
   PUBMED   10651948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_231873.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.19587.1,
                                           SRR26643299.19580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000004.1  97822264-97822339   c
            77-403              JAXUCZ010000004.1  97820909-97821235   c
            404-518             JAXUCZ010000004.1  97818457-97818571   c
            519-712             JAXUCZ010000004.1  97817433-97817626   c
            713-855             JAXUCZ010000004.1  97815377-97815519   c
            856-1006            JAXUCZ010000004.1  97811778-97811928   c
            1007-1086           JAXUCZ010000004.1  97795191-97795270   c
            1087-1303           JAXUCZ010000004.1  97782873-97783089   c
            1304-1504           JAXUCZ010000004.1  97775282-97775482   c
            1505-1603           JAXUCZ010000004.1  97769300-97769398   c
            1604-1762           JAXUCZ010000004.1  97769059-97769217   c
            1763-1900           JAXUCZ010000004.1  97764693-97764830   c
            1901-1991           JAXUCZ010000004.1  97764190-97764280   c
            1992-2091           JAXUCZ010000004.1  97761009-97761108   c
            2092-2610           JAXUCZ010000004.1  97756762-97757280   c
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..2610
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor subunit beta 2"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
     CDS             1..2610
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor, beta 2"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2
                     precursor"
                     /protein_id="NP_001178679.1"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
                     /translation="MAHTVRGCSLALIFLFMWLLIKANIDVCKLGTVTVQPAPVIPLG
                     STANISCSLNPKQGCSHYPSYNELILLKFVNDVLVEKLHGKKVHGHPSHSSIFQVTNL
                     SLGMTLFVCKLNCSNSQKTQPVPVCGVEISVGVAPESPQSISCVQKGEHGTVACSWNS
                     GKVTYLKTYYTLQLTGPNNVTYQNQCYSDNRQNCSRLDLGINLTPDLAESRFIVHVTA
                     TNDLGNSSSLLHTFTFLDIVRPLPPWDIRINFLNASGSRCTLQWEDEGQVVLNRLRYQ
                     PLNSTSWNMVNATNAKGRYDLQDLRPFTEYEFQISSKLHLSQGSWSNWSESLRTRTPE
                     EEPVGTLDIWYMKQDIDCDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNT
                     TRHTFWTGVIPRTGAWTASVSAANSKGTSAPTHINIVDLCGTGFLAPHQVSAKSGNMD
                     NIMVTWQPPGKADSVIREYIVEWRALQQGSVMNLTPHWLRIPPYNMSALISEKIKPYI
                     CYEIRVHALSEDQGGCSSIRGDSSHKVPLSGPHITAITEKKESLFISWTHIPFLEQRG
                     CILHYRIYWKERHSTAQPELCEIQYRHSQNSHPISSLQPKVTYVLWMTAVTAAGESPQ
                     GNEREFCPQGKANWKTFVISSICIAIIVVGTFSIRYFRQKAFTLLSTLKPQWYCRTIP
                     DPANSTWVKKYPIMEEKIQPPMDNLLMAWSAPEEPEPLIINEVLYQMIPVGRQPYCFK
                     RGQGFQGYSTSKEDTIYLATNPQTTGTLTAESRQLVNLYKVLGSRDPDSKLGNLTSPL
                     TVTPVNYLPTHEGYLPSNIEDLSSHEVDPSDSLDLDHQHISLSIFASSSLRPLTFCGE
                     RLTLDRLKMGYEK"
     sig_peptide     1..69
                     /gene="Il12rb2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    82..360
                     /gene="Il12rb2"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    82..360
                     /gene="Il12rb2"
                     /note="Ig-like C2-type domain; Region: Lep_receptor_Ig;
                     pfam06328"
                     /db_xref="CDD:461878"
     misc_feature    718..996
                     /gene="Il12rb2"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    718..996
                     /gene="Il12rb2"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(718..720,904..906,958..960)
                     /gene="Il12rb2"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(718..720,904..906,958..960)
                     /gene="Il12rb2"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(961..966,970..975)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(961..966,970..975)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1312..1578
                     /gene="Il12rb2"
                     /note="Fibronectin type III domain; Region: fn3;
                     pfam00041"
                     /db_xref="CDD:394996"
     misc_feature    1312..1578
                     /gene="Il12rb2"
                     /note="Fibronectin type III domain; Region: fn3;
                     pfam00041"
                     /db_xref="CDD:394996"
     misc_feature    order(1564..1569,1573..1578)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1564..1569,1573..1578)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1606..1890
                     /gene="Il12rb2"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1606..1890
                     /gene="Il12rb2"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1861..1866,1870..1875)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1861..1866,1870..1875)
                     /gene="Il12rb2"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     exon            1..76
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            77..403
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..518
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..712
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..855
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1006
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1086
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1303
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1504
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1603
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1762
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1900
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1991
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2091
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2610
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcacaca ctgttagagg atgctcattg gcacttattt ttttgttcat gtggctgttg
       61 attaaagcaa atatagatgt gtgcaagctt ggcaccgtga ctgtccagcc tgcccctgtg
      121 attccacttg ggtcaactgc caatatttcc tgctctttga atcccaaaca aggctgttcg
      181 cattatccta gttataacga attaatcctc ttaaagtttg tcaatgatgt ccttgtcgaa
      241 aaactccatg gcaaaaaagt ccatggccac cctagtcatt cctccatatt tcaagtcacc
      301 aacctgtctc ttggtatgac tctgtttgtc tgcaagctaa actgtagcaa ctctcaaaag
      361 acacaaccag tgccagtgtg tggagtggag atctcagtcg gtgttgctcc agagtcacct
      421 caaagcatat catgtgtcca gaaaggagag catggaactg tggcctgctc ctggaactct
      481 gggaaagtta cttatctgaa aacctattac actttacagt taactggacc aaacaatgtg
      541 acctatcaga accagtgtta ttctgacaat cgtcagaatt gtagtcgtct ggatcttggg
      601 atcaatctga cccctgattt agccgaatcc aggttcatag tccatgttac tgccaccaat
      661 gatcttggaa attcttcttc acttctgcat acattcacat tcttggacat agtgaggcct
      721 cttcctccgt gggacatcag aatcaacttt ctaaatgctt ctgggagcag atgtacactg
      781 cagtgggaag atgaggggca agtggtactc aatcgactca gataccagcc tcttaacagc
      841 acatcctgga atatggttaa tgctacaaat gccaaaggaa gatatgacct gcaagatctg
      901 agaccattca cagaatatga atttcagatc tcctctaagc tacatctctc tcagggaagt
      961 tggagtaatt ggagtgagtc actgagaact cgaacaccag aggaagagcc tgttgggaca
     1021 ttagacatct ggtacatgaa acaagatatt gactgtgaca gacaacagat ctctcttttc
     1081 tggaagagtc tgaatccatc agaggcaagg gggaagatcc tccactatca ggtgacttta
     1141 caggaggtga cgaagaaaac tacactgcag aatactacaa gacatacctt ctggaccggg
     1201 gtcattccca gaactggggc ttggactgca tctgtgtctg cagccaactc aaaaggcact
     1261 tctgcaccca ctcacattaa catagtggac ctgtgtggca ctgggttcct ggctcctcac
     1321 caggtctctg caaagtcagg gaacatggac aacatcatgg tgacctggca gcctcctggg
     1381 aaagctgact ctgtgattcg ggagtacata gtggaatgga gggctctcca acaagggagc
     1441 gtcatgaacc ttaccccaca ctggctgcga attcccccct acaacatgtc tgctctgatt
     1501 tcagagaaga taaagcccta tatctgttac gaaatccggg tacatgcact gtcagaggac
     1561 caaggagggt gcagctccat ccggggtgac tccagtcaca aagtgccact gagtggccct
     1621 catatcactg ctatcacaga gaaaaaggaa agccttttta tttcctggac ccacatccct
     1681 ttcctggagc aaaggggctg catcctccat tacagaatat attggaagga gcgacactct
     1741 actgcgcaac ccgagctctg tgaaattcag tacagacact ctcaaaactc acatccaata
     1801 agcagcctac agcccaaggt gacatatgtc ctatggatga cagctgtgac agctgctggt
     1861 gaaagtcccc aaggaaatga aagggaattt tgtccacagg gcaaagccaa ctggaaaaca
     1921 ttcgtgatat caagcatttg catcgctatc atcgtggtgg gcactttctc aattcgttac
     1981 ttcaggcaaa aggcatttac tctcctttct actctcaaac cccaatggta ttgcagaact
     2041 attccagatc cagcaaatag cacttgggta aagaagtacc ccattatgga ggagaagatc
     2101 cagccaccta tggacaatct cctgatggcc tggtccgctc ctgaagagcc tgagcccctg
     2161 atcatcaatg aagtcctcta ccaaatgatc ccagtaggca gacaacccta ttgcttcaaa
     2221 agaggacaag ggttccaagg ttactctacc tccaaggaag acacaatata ccttgccacc
     2281 aatccacaaa ctacaggaac tctcacagct gagtcgagac aactagtgaa tctatacaag
     2341 gtgctaggaa gcagggaccc tgactcaaaa ctgggcaacc tgaccagccc cttgacagtc
     2401 accccagtga actaccttcc tacccatgaa ggctatttac cctccaacat agaagacctc
     2461 tcatcacatg aagttgaccc aagtgattct ttagacctgg accatcaaca tatttctctt
     2521 tccatttttg catcaagttc tctccgccca ctcaccttct gtggtgagag gctgactcta
     2581 gatcggttaa agatgggcta cgagaaatga
//
LOCUS       NM_001099480            2595 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 60 (Vom2r60), mRNA.
ACCESSION   NM_001099480 XM_001065827 XM_577202
VERSION     NM_001099480.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000012.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XM_577202.1, XM_001065827.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000012.1  7794243-7794445     c
            204-246             JAXUCZ010000012.1  7764868-7764910     c
            247-516             JAXUCZ010000012.1  7761942-7762211     c
            517-1323            JAXUCZ010000012.1  7760477-7761283     c
            1324-1551           JAXUCZ010000012.1  7749343-7749570     c
            1552-1675           JAXUCZ010000012.1  7695091-7695214     c
            1676-2595           JAXUCZ010000012.1  7688051-7688970     c
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2595
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="vomeronasal 2 receptor, 60"
                     /db_xref="GeneID:501794"
                     /db_xref="RGD:1560561"
     CDS             1..2595
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 60 precursor"
                     /protein_id="NP_001092950.1"
                     /db_xref="GeneID:501794"
                     /db_xref="RGD:1560561"
                     /translation="MMLLLIFMFLLLQYSSDVYSFDRSSCAAKTKTSVYKDGDMVLAA
                     FLPLFTITIDSASDNQSNNNFYIHQHVKECKFIHSFHFIVLAMVYAIEEINRNPHILP
                     NVSLGYDIYNVLFNEWWILNRCITWLSGPKKYVPNYTCRREMKSIAALTGISWIISTN
                     IGTLLELYKYPQLTIGSFDPNLNNHEQFHDIYQIAYKDMSLTHGIVSLLNYFHWNWVG
                     LIVSEGQNGFQIISELRAEMDRNKICVDFVEMIRVSEVSYLPSYLLSPTHLAKSTANV
                     IITYGDSDFMRGFLFYLRQILVTRKVWIMNSDWDVIIQSKHFILQSFHGSLIFAHHHK
                     ETSGYRNFIQTVHPSKYPEDFYLTRFWFYFFNCSFADDDCNTLENCLPNASLHETPGS
                     HFDMVMTEFAYNIYNAVYAVAHSLHKMLLQQVEVTPVKEAEDLIFSAWQLHPFLKNMQ
                     FTNPAGEQVNLNEKMKLNADYDILNYWNFPEGLQLKVKVGQFSPYGPLGQQLSLSEDT
                     IEWPTEITETPRSICSESCGPGFRKSLPEGKVSCCFDCVPCPENEISNETDVDQCMQC
                     LDHQYANTAQNHCLQKSMTFLDYEDPMGISLSCIALCFSALTSLVLSIFLKQKNTPIV
                     KANNRTLTYILLIALNFCFLCSFLFIGHPNTATCILQQTTFAVVFTVAVSTVLAKTIT
                     VVLAFKVTAPGRRIRWLLVTRAPNFIVPICTLIQIILCGVWLGNSPPFIDTDTRSEHE
                     HIIIMCNKGSVTAFYCVQGYLGALALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSV
                     WVTFLPVYHSTKGKHMVVVEVFSILVSSAGLLGCIFAPKCYIILLRPQRNSIQGHRDK
                     IHYNYKTS"
     sig_peptide     1..60
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    121..1533
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    121..1533
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(241..243,526..531,1201..1203)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(241..243,526..531,1201..1203)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,487..489,748..750)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(349..351,358..360,487..489,748..750)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1555..1716
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1555..1716
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1774..2529
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1774..2529
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1774..1851
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1774..1851
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1783..1785,1792..1797,1804..1809,1813..1818,
                     1918..1920,1930..1932,1939..1944,1966..1968,1978..1980)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1783..1785,1792..1797,1804..1809,1813..1818,
                     1918..1920,1930..1932,1939..1944,1966..1968,1978..1980)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1885..1950
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1885..1950
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1945..1947,1981..1986,1993..1998,2005..2007,
                     2245..2247,2260..2262,2269..2274,2281..2283,2383..2385,
                     2392..2397,2404..2406,2416..2418,2440..2445,2452..2454,
                     2461..2463,2473..2475)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1945..1947,1981..1986,1993..1998,2005..2007,
                     2245..2247,2260..2262,2269..2274,2281..2283,2383..2385,
                     2392..2397,2404..2406,2416..2418,2440..2445,2452..2454,
                     2461..2463,2473..2475)
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1975..2049
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1975..2049
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2119..2169
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2119..2169
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2248..2328
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2248..2328
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2350..2421
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2350..2421
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2434..2511
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2434..2511
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..203
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            204..246
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            247..516
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1323
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1551
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1675
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2595
                     /gene="Vom2r60"
                     /gene_synonym="RGD1560561"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgcttc ttctgatttt tatgttcctg cttctgcaat attccagtga tgtctactcc
       61 tttgaccgct cttcctgtgc tgcaaagaca aaaactagtg tatacaagga tggagatatg
      121 gtacttgctg catttttacc tctttttact attaccattg attctgcatc tgataatcaa
      181 agcaataata atttctatat tcatcagcat gtaaaagaat gcaaatttat ccattctttt
      241 cactttattg ttctggcaat ggtttatgcc attgaggaga tcaacagaaa ccctcatatt
      301 ttacccaatg tgtctctggg atatgatata tataatgtac tgttcaatga atggtggata
      361 ttgaatagat gtatcacatg gctttctggg ccaaagaagt atgtgcctaa ttacacgtgt
      421 aggagagaaa tgaagtcaat tgcagcccta acaggcatat catggataat atctaccaat
      481 atagggacac tgctagaact ctacaaatat ccacagctga ccattgggtc ttttgaccct
      541 aacctgaata atcatgagca gtttcatgac atttatcaaa tagcctacaa ggacatgtct
      601 ctcacccatg gcattgtctc cttgttgaat tatttccact ggaactgggt aggattgatt
      661 gtatctgaag gacaaaatgg ttttcagata atatcagaat tgagggcaga aatggacaga
      721 aacaaaatat gtgtagactt tgtggaaatg atccgagtta gtgaagtatc ttatttacca
      781 agctacttat tgagtcctac tcatcttgca aaatcaacag caaatgtgat catcacctat
      841 ggtgacagtg attttatgag aggctttctg ttttatttaa gacaaatttt agttacaagg
      901 aaagtctgga tcatgaactc agattgggat gtcatcatcc agtcaaagca tttcatttta
      961 cagtcattcc atgggagcct catctttgca catcaccaca aagaaacctc tggttacaga
     1021 aattttatcc aaacagttca tccttccaaa tacccagaag atttttacct tacaaggttt
     1081 tggttctact tttttaactg ctcatttgct gatgatgact gcaatacact agagaactgt
     1141 ctgcctaatg cttccttgca tgaaacaccg gggagccatt ttgacatggt catgactgaa
     1201 tttgcttata atatatacaa tgcagtatat gctgtggccc acagccttca caagatgctt
     1261 cttcagcaag tagaagtaac accagtaaaa gaggcagaag acctgatatt ttcagcctgg
     1321 cagctgcacc cttttctgaa gaacatgcag tttactaatc ctgctggaga acaagtgaat
     1381 ttgaatgaga aaatgaagtt gaatgcagac tatgacattc tcaactactg gaactttcca
     1441 gaaggtcttc aacttaaggt gaaagttgga caattttccc cttatggtcc acttggtcaa
     1501 caattatctt tatctgagga cacaatagag tggcccaccg aaattacaga gactcccagg
     1561 tctatatgca gtgaaagttg tggtcctgga ttcagaaaat ccctcccaga aggaaaagtg
     1621 agctgttgtt ttgactgcgt tccatgccca gagaatgaaa tttccaatga aacagatgtg
     1681 gatcagtgta tgcagtgtct agaccatcaa tacgccaaca cagcacaaaa ccactgcctc
     1741 caaaagtcta tgaccttcct ggattatgaa gaccccatgg ggataagtct gtcctgcata
     1801 gccttgtgct tctctgcact gacatctcta gttcttagca tctttctgaa gcagaagaac
     1861 actcccattg tgaaggcaaa taaccgcact ctcacctaca tcctgctcat tgcccttaac
     1921 ttctgttttc tctgctcttt tctcttcatt ggccatccca acacagccac ttgcatcctg
     1981 caacagacca catttgcagt ggtgttcact gtggctgttt ccactgtctt ggccaaaacg
     2041 attaccgtgg ttctggcctt caaggtcacc gctccaggaa gaagaatcag gtggttgttg
     2101 gtaactcggg cacctaactt catagttccc atctgtacct tgatccaaat tatcttgtgt
     2161 ggagtctggc tgggaaactc ccctccgttc attgacacag atacacgctc tgaacatgaa
     2221 catattatca tcatgtgcaa caagggctca gtcactgcct tctactgtgt gcagggttac
     2281 ctgggggctc tagccctggg aagcttcacc ttggctttct tggccaggaa cctacctgac
     2341 accttcaatg aagccaagtt cctgacattc agcatgctgg tgttctgcag tgtctgggtc
     2401 accttcctcc ctgtctacca cagtactaag gggaagcaca tggtagttgt ggaggtcttc
     2461 tccatcttgg tctccagtgc aggacttctt ggttgtatct ttgcccccaa atgctacatt
     2521 attttgttaa gaccacaaag gaactctatt cagggtcaca gagacaaaat acattataat
     2581 tataagactt cataa
//
LOCUS       NM_001099512            2544 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus vomeronasal 2 receptor, 43 (Vom2r43), mRNA.
ACCESSION   NM_001099512 XM_001053623
VERSION     NM_001099512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2544)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Aug 15, 2007 this sequence version replaced XM_001053623.1.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  149228250-149228455 c
            207-486             JAXUCZ010000001.1  149212312-149212591 c
            487-1293            JAXUCZ010000001.1  149211120-149211926 c
            1294-1521           JAXUCZ010000001.1  149209937-149210164 c
            1522-1645           JAXUCZ010000001.1  149209387-149209510 c
            1646-2544           JAXUCZ010000001.1  149205927-149206825 c
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2544
                     /gene="Vom2r43"
                     /note="vomeronasal 2 receptor, 43"
                     /db_xref="GeneID:679593"
                     /db_xref="RGD:1587090"
     CDS             1..2544
                     /gene="Vom2r43"
                     /codon_start=1
                     /product="vomeronasal 2 receptor 43 precursor"
                     /protein_id="NP_001092982.1"
                     /db_xref="GeneID:679593"
                     /db_xref="RGD:1587090"
                     /translation="MIDMFSLILVLLFLKASLLFCTLNDPKCFLRIKDKKNVDGDKEV
                     DCFFSIYAKHGHVKNDFFSGNLDKQLTTKNIHLILSLYFSIEEINSTPQVLPNISLLV
                     KIECNLLADRSKISLSSRKGDYFPNFDCRNQRRYLIVFTGPMWFPTAMLGPLLYISRT
                     PELYYGPFHPLLNTYEQFPYLYQMAIKDTSIAIGMVTLVIYFSWNWVGLMISDDDLGL
                     QFASELREEMQRYDICLAFVTVITYNSKLFLTMAGMYYNQIIMSLAKVVIIYGDIDSF
                     LQVIFRLWQFVDIRRIWIATSQWDIITSNGEFLFNSFHGTLSFSHHYSEISGFKEFIQ
                     TVYPLNYSNTISPAKLWWVNFNCFWPSSNCKKLKKCSRKMLLKWLSNNQFEMAMSETN
                     YNLYNAVYAVAHSLHELILQQANTLSNNVEKELEFDSLQVLSSLKKIQFVNPAGDLVN
                     LNQKENLNVDYDIFYTGDFLQSYGIKVKIGNFFKYLTQPQKLLMFDEMVDWATDIRQT
                     LPSICSTPCNPGFRKSPQEGKAVCCFDCNPCPENEISNMTDMDYCYKCLDNQYANSEG
                     THCLSKTVIFLSYEDPIGVTLACLALCFSALTAVVFGIFLRNQDTLIVKANNRALSYC
                     LLISLIYCFLCSLLFIGKPHMVTCIMQQTIFAVAFTVAVSTVLSKTITVVLAFKFTLP
                     SKKMRWLMTSGTSVLIIPICTMIQLIICGIWLGTYPPYVDSDGHIEHGHILIVCNKGS
                     VTAFYCVLGYLGSIALASFTVAFLARNLPDTFNEAKFLTFSMLVFCSVWLTFLPVYHS
                     TSGKALVIVEVFCILTSTAGLLICIFAPKCYIILLTPKNNSFHTFRHKC"
     sig_peptide     1..63
                     /gene="Vom2r43"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    127..1503
                     /gene="Vom2r43"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    127..1503
                     /gene="Vom2r43"
                     /note="Ligand-binding domain of the V2R pheromone
                     receptor, a member of the family C receptors within the
                     G-protein coupled receptor superfamily; Region:
                     PBP1_pheromone_receptor; cd06365"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,496..501,1171..1173)
                     /gene="Vom2r43"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    order(217..219,496..501,1171..1173)
                     /gene="Vom2r43"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:380588"
     misc_feature    1531..1686
                     /gene="Vom2r43"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1531..1686
                     /gene="Vom2r43"
                     /note="Nine Cysteines Domain of family 3 GPCR; Region:
                     NCD3G; pfam07562"
                     /db_xref="CDD:462210"
     misc_feature    1744..2499
                     /gene="Vom2r43"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..2499
                     /gene="Vom2r43"
                     /note="vomeronasal type-2 pheromone receptors, member of
                     the class C family of seven-transmembrane G
                     protein-coupled receptors; Region: 7tmC_V2R_pheromone;
                     cd15283"
                     /db_xref="CDD:320410"
     misc_feature    1744..1821
                     /gene="Vom2r43"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    1744..1821
                     /gene="Vom2r43"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320410"
     misc_feature    order(1753..1755,1762..1767,1774..1779,1783..1788,
                     1888..1890,1900..1902,1909..1914,1936..1938,1948..1950)
                     /gene="Vom2r43"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1753..1755,1762..1767,1774..1779,1783..1788,
                     1888..1890,1900..1902,1909..1914,1936..1938,1948..1950)
                     /gene="Vom2r43"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:320410"
     misc_feature    1855..1920
                     /gene="Vom2r43"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    1855..1920
                     /gene="Vom2r43"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320410"
     misc_feature    order(1915..1917,1951..1956,1963..1968,1975..1977,
                     2215..2217,2230..2232,2239..2244,2251..2253,2353..2355,
                     2362..2367,2374..2376,2386..2388,2410..2415,2422..2424,
                     2431..2433,2443..2445)
                     /gene="Vom2r43"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    order(1915..1917,1951..1956,1963..1968,1975..1977,
                     2215..2217,2230..2232,2239..2244,2251..2253,2353..2355,
                     2362..2367,2374..2376,2386..2388,2410..2415,2422..2424,
                     2431..2433,2443..2445)
                     /gene="Vom2r43"
                     /note="putative allosteric modulator binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:320410"
     misc_feature    1945..2019
                     /gene="Vom2r43"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    1945..2019
                     /gene="Vom2r43"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320410"
     misc_feature    2089..2139
                     /gene="Vom2r43"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2089..2139
                     /gene="Vom2r43"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320410"
     misc_feature    2218..2298
                     /gene="Vom2r43"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2218..2298
                     /gene="Vom2r43"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320410"
     misc_feature    2320..2391
                     /gene="Vom2r43"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2320..2391
                     /gene="Vom2r43"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320410"
     misc_feature    2404..2481
                     /gene="Vom2r43"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     misc_feature    2404..2481
                     /gene="Vom2r43"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320410"
     exon            1..206
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
     exon            207..486
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1293
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1521
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1645
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2544
                     /gene="Vom2r43"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatagata tgttttcctt gattttagtc ttattgttct taaaggcttc cttgcttttc
       61 tgcactttga atgatcccaa gtgcttttta agaataaaag acaagaaaaa cgtggatgga
      121 gataaggaag ttgattgttt tttttccatt tatgctaaac atgggcatgt gaagaatgat
      181 ttctttagtg gaaatctaga caagcagttg acaactaaga acatccattt gattttatct
      241 ctttattttt ctattgagga aatcaatagc acccctcagg ttttacccaa tatatctctg
      301 ctggttaaaa ttgaatgtaa cttattggct gatcggagta aaatcagttt atcctcaaga
      361 aaaggtgatt actttcctaa cttcgactgt agaaaccaga gaagatactt aattgtattt
      421 acaggaccaa tgtggttccc aactgccatg cttggaccac ttctgtatat ctccagaact
      481 ccagagcttt actatgggcc atttcatcct cttctcaata cctatgaaca atttccttat
      541 ctgtatcaga tggctatcaa ggacacatct atagctattg gcatggtgac tttggtgatt
      601 tatttcagct ggaactgggt aggattgatg atttcagatg atgatctagg acttcaattt
      661 gcctctgagt tgagagaaga aatgcaaaga tatgacatct gtttagcctt tgtgactgtt
      721 atcacatata acagcaaatt attcttgaca atggctggca tgtattataa tcaaatcata
      781 atgtctttag caaaagttgt tatcatttat ggtgacatag attcttttct acaagtaatc
      841 tttagactat ggcagtttgt agacattcgg agaatctgga ttgctacatc acagtgggat
      901 ataattacaa gtaatggaga attccttttc aactcctttc acggcaccct cagcttttca
      961 catcattact ctgagatatc tggttttaaa gaatttatac agacagtgta ccctttaaac
     1021 tacagtaaca ctatctctcc tgctaaatta tggtgggtga attttaattg tttttggcca
     1081 tcatctaatt gtaagaaatt gaagaaatgt tcaagaaaaa tgctcctgaa atggttatct
     1141 aacaaccagt ttgaaatggc catgagtgaa acaaattata acctatacaa tgctgtgtat
     1201 gctgtggccc attcactcca tgagttaatt ctgcagcaag caaatacatt gtcaaataac
     1261 gttgagaaag aactggagtt tgattctttg caggtcctct cttccctgaa gaagatccag
     1321 tttgtaaatc ctgctgggga cctagtgaac ctgaatcaga aagaaaactt gaatgtagat
     1381 tatgatattt tctacacagg agatttttta caaagttatg gaattaaagt gaaaatagga
     1441 aactttttca aatacctcac acaacctcaa aaattgctta tgtttgacga aatggtagac
     1501 tgggccacag atattagaca gactctaccc tcaatatgca gtacaccttg caatccagga
     1561 tttagaaaat cccctcagga gggaaaggct gtctgttgct ttgattgtaa cccctgccca
     1621 gagaatgaga tttccaatat gacagatatg gattattgtt acaaatgtct agataatcaa
     1681 tatgccaact cagaaggaac tcattgtctc tccaaaactg tgatattcct gtcttatgaa
     1741 gaccccatag gagtgactct agcatgcttg gccctatgct tttctgctct cacagctgtt
     1801 gtatttggta tctttttaag aaaccaagac actctcattg tcaaggccaa taaccgagct
     1861 ctcagctact gcctgctcat ctcactcatc tattgttttc tttgttctct gctgttcatt
     1921 ggaaaaccac atatggtaac atgcatcatg cagcagacca tatttgcagt tgcgtttact
     1981 gttgctgtct ctactgtttt atccaagaca attactgtgg tactggcctt caagtttact
     2041 cttcctagta aaaagatgag atggctaatg acatcaggaa catcagtctt gatcattccc
     2101 atatgcacca tgatccaact gatcatttgt ggaatctggc tgggaactta tccaccatat
     2161 gttgatagtg atgggcatat tgaacatggc catattttga ttgtttgcaa caaaggttca
     2221 gttactgcct tctattgtgt cctaggatac ttgggttcta ttgcactggc aagtttcact
     2281 gtagcattct tagccaggaa tcttcctgat acattcaatg aagccaagtt cctgacattt
     2341 agcatgctgg tgttctgtag tgtctggctc actttccttc ctgtctacca tagcaccagt
     2401 ggcaaggcct tagtcattgt ggaggtattc tgcatcttga cctccactgc aggactacta
     2461 atctgcatct ttgctccaaa atgctacatt attttgttaa cacctaaaaa caactctttt
     2521 cataccttta ggcacaaatg ctaa
//
LOCUS       NM_001192014             738 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus notochord homeobox (Noto), mRNA.
ACCESSION   NM_001192014 XM_578357
VERSION     NM_001192014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Alten,L., Schuster-Gossler,K., Beckers,A., Groos,S., Ulmer,B.,
            Hegermann,J., Ochs,M. and Gossler,A.
  TITLE     Differential regulation of node formation, nodal ciliogenesis and
            cilia positioning by Noto and Foxj1
  JOURNAL   Development 139 (7), 1276-1284 (2012)
   PUBMED   22357932
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Vidigal,J.A., Morkel,M., Wittler,L., Brouwer-Lehmitz,A., Grote,P.,
            Macura,K. and Herrmann,B.G.
  TITLE     An inducible RNA interference system for the functional dissection
            of mouse embryogenesis
  JOURNAL   Nucleic Acids Res 38 (11), e122 (2010)
   PUBMED   20350929
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Zizic Mitrecic,M., Mitrecic,D., Pochet,R., Kostovic-Knezevic,L. and
            Gajovic,S.
  TITLE     The mouse gene Noto is expressed in the tail bud and essential for
            its morphogenesis
  JOURNAL   Cells Tissues Organs 192 (2), 85-92 (2010)
   PUBMED   20197654
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Beckers,A., Alten,L., Viebahn,C., Andre,P. and Gossler,A.
  TITLE     The mouse homeobox gene Noto regulates node morphogenesis,
            notochordal ciliogenesis, and left right patterning
  JOURNAL   Proc Natl Acad Sci U S A 104 (40), 15765-15770 (2007)
   PUBMED   17884984
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17554]
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Abdelkhalek,H.B., Beckers,A., Schuster-Gossler,K., Pavlova,M.N.,
            Burkhardt,H., Lickert,H., Rossant,J., Reinhardt,R., Schalkwyk,L.C.,
            Muller,I., Herrmann,B.G., Ceolin,M., Rivera-Pomar,R. and Gossler,A.
  TITLE     The mouse homeobox gene Not is required for caudal notochord
            development and affected by the truncate mutation
  JOURNAL   Genes Dev 18 (14), 1725-1736 (2004)
   PUBMED   15231714
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Mitrecic,D., Kostovic-Knezevic,L. and Gajovic,S.
  TITLE     Morphological features of tail bud development in truncate mouse
            mutants
  JOURNAL   Cells Tissues Organs 178 (1), 23-32 (2004)
   PUBMED   15550757
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Dietrich,S., Schubert,F.R. and Gruss,P.
  TITLE     Altered Pax gene expression in murine notochord mutants: the
            notochord is required to initiate and maintain ventral identity in
            the somite
  JOURNAL   Mech Dev 44 (2-3), 189-207 (1993)
   PUBMED   8155581
REFERENCE   8  (bases 1 to 738)
  AUTHORS   THEILER,K.
  TITLE     Anatomy and development of the 'truncate' (boneless) mutation in
            the mouse
  JOURNAL   Am J Anat 104, 319-343 (1959)
   PUBMED   13837681
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_578357.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000004.1  119518663-119519041
            380-591             JAXUCZ010000004.1  119520022-119520233
            592-738             JAXUCZ010000004.1  119522756-119522902
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="notochord homeobox"
                     /db_xref="GeneID:502857"
                     /db_xref="RGD:1562910"
     CDS             1..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="notochord homolog"
                     /codon_start=1
                     /product="homeobox protein notochord"
                     /protein_id="NP_001178943.1"
                     /db_xref="GeneID:502857"
                     /db_xref="RGD:1562910"
                     /translation="MSSPVPQPASSGTQVQPGDLGPCPVAVSPVVPNHLARGRLESSF
                     SVEAILARPETREHSATSLPLSTCTSLNFGSVSQYQVLPWVCSTGTWLPTYLSVGIYP
                     MCSMSCMPGLNVTHLFCQQGLRLTGSELPSCLGPLKRAPTVNLQDHNTERHQKRVRTM
                     FSEQQLGELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKSP
                     PPDAMEEPSNSSEGNVRNEDAEAGVGS"
     misc_feature    463..633
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    463..633
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            1..379
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
     exon            380..591
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Noto"
                     /gene_synonym="RGD1562910"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccagcc cagtgcccca gcctgcttcc tcaggcactc aggtccagcc cggggacttg
       61 ggaccctgtc cggtggctgt ttccccagta gtcccgaacc acctagctcg gggacgcctg
      121 gagtcctcct tctctgttga ggccatcctg gcgagacccg agactcgtga gcactctgcc
      181 acgtctctgc cgctctctac ctgcaccagt ctgaactttg gctctgtgtc acagtaccag
      241 gtcctgccct gggtgtgctc cacggggact tggctgccca cctacctgag cgtaggcatc
      301 tacccgatgt gctccatgtc ctgcatgccc ggattgaatg tgactcacct cttctgccaa
      361 cagggcctca gactcacagg gtcagagcta ccttcctgtc taggccctct gaaacgggca
      421 cccactgtga accttcagga ccacaatacc gagagacacc aaaagagggt tcgcacaatg
      481 tttagcgagc agcagctggg agagttggag aaggtatttg caaagcagca caacctggtg
      541 gggaaggaga gagcccagtt ggctgccagg ctgcacttga cagagaacca ggtaaggatc
      601 tggttccaga atcgcagggt aaagtatcaa aagcagcaaa aactgaagtc acctccccct
      661 gatgccatgg aggagccctc caacagctca gagggcaacg tccggaatga agacgctgag
      721 gcaggagttg gcagttaa
//
LOCUS       NM_001106336             869 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus membrane spanning 4-domains A10 (Ms4a10),
            transcript variant 2, mRNA.
ACCESSION   NM_001106336 XM_001074991 XM_215198
VERSION     NM_001106336.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074991.1, XM_215198.3.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..869
                     /gene="Ms4a10"
                     /note="membrane spanning 4-domains A10"
                     /db_xref="GeneID:293739"
                     /db_xref="RGD:1307478"
     exon            1..58
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Ms4a10"
                     /note="upstream in-frame stop codon"
     exon            59..254
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..779
                     /gene="Ms4a10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     membrane-spanning 4-domains, subfamily A, member 10"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     10 isoform 2"
                     /protein_id="NP_001099806.1"
                     /db_xref="GeneID:293739"
                     /db_xref="RGD:1307478"
                     /translation="MSRQVPTVTASSAIGQASQWQSPGPSQPAQKVAQPQHLVPDGYL
                     EKPMEGSGLLQKLGGFHIAIAFAHLTFGGYLISTVKNLHLVVLKCWYPLWGAVSFLIS
                     GILATTTVTFPKTSLKILCVVANVISLFCALAGFFVIAKDLFLENPFPWPIWRPYPNP
                     TSYIQRLELTLLCFTFLEIFLSASTAITACRMKRPHAEDKDDTPLIPDTPMELKGLSL
                     GPPPSYKDVTQDKD"
     misc_feature    249..650
                     /gene="Ms4a10"
                     /note="CD20-like family; Region: CD20; pfam04103"
                     /db_xref="CDD:461174"
     misc_feature    249..650
                     /gene="Ms4a10"
                     /note="CD20-like family; Region: CD20; pfam04103"
                     /db_xref="CDD:461174"
     exon            255..374
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            375..431
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            432..563
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            564..674
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            675..768
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            769..869
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcagctc tggatagtaa gggacagctg aagcccacag aagaggtccc tgggccagcc
       61 agggtttcct accagagtca atgtctagac aagttcccac agtgactgcc agcagtgcca
      121 ttggacaagc ctctcaatgg cagagcccag gaccttccca gcctgcacag aaagtggccc
      181 agccccagca tctggttccg gatgggtacc ttgagaaacc catggaggga agtggtctcc
      241 tgcagaagtt gggtggcttt cacatcgcca ttgcttttgc acacctgacc tttggtggtt
      301 acctgatctc cacagtcaag aatctgcact tggtggtgtt gaagtgctgg tatccactct
      361 ggggagctgt ttcttttctc atttcaggga tcttagccac gacaacagtg acatttccca
      421 agacctctct gaaaattctg tgtgtggtag caaacgtcat cagcttgttc tgcgccctgg
      481 ccggcttctt cgtcattgcc aaggacctct ttctggagaa tccttttcca tggccaatct
      541 ggagaccata ccccaacccc acaagctaca tccaaagact agagctgact ctgctctgct
      601 ttaccttcct ggagatcttc ctgtcggcgt ccaccgccat tacagcctgt aggatgaaac
      661 gcccgcatgc agaggacaag gatgataccc ctctcatccc tgacacacct atggaactta
      721 aaggtctgtc actaggacca ccaccatcct ataaagatgt gactcaagat aaagactgag
      781 ttcctgcagt accaagtcca tcgccgcctc ccatcggctg gagtctgatg atgacacagg
      841 cgtgactcaa taaaagcata actactata
//
LOCUS       NM_001107161            1036 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus MISP family member 3 (Misp3), transcript variant
            2, mRNA.
ACCESSION   NM_001107161 XM_001072269 XM_222453
VERSION     NM_001107161.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001072269.1, XM_222453.4.
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1036
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="MISP family member 3"
                     /db_xref="GeneID:304650"
                     /db_xref="RGD:1310262"
     exon            1..58
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
     exon            59..688
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..777
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /codon_start=1
                     /product="uncharacterized protein MISP3"
                     /protein_id="NP_001100631.1"
                     /db_xref="GeneID:304650"
                     /db_xref="RGD:1310262"
                     /translation="METPIQREIRRSCEREESLRRSRGLSPGRAGEELIELRVRPVLS
                     RPGSGIPLPRALERARAGAKMQRDIEREAHRQAALASPAVPEPSARPRPQPLDELKRF
                     FEAAAEDGASLQRQPEAGGRLHPALQDGCPVLGQLPPLVAPSLLEQEVLRVREREREL
                     QLQRRSIYGAAEDREPAPSLTQSRGDGKLAVTWPPRRQASENGLEKERRP"
     misc_feature    253..744
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="A-kinase anchor protein 2 C-terminus; Region:
                     AKAP2_C; pfam15304"
                     /db_xref="CDD:464630"
     misc_feature    253..744
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="A-kinase anchor protein 2 C-terminus; Region:
                     AKAP2_C; pfam15304"
                     /db_xref="CDD:464630"
     exon            689..762
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1036
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcaaaga agagtgctgg cgacgcctta gaacctcggg cggcggctgc aaccacagtt
       61 gtgcccctgc gtcggctcag aggcctccag gtgtgttttc caccgaggcc cgtggcatcc
      121 aaaccagcgc ctgcggaact gctgatggag acgcccatcc agcgcgaaat ccgccgtagc
      181 tgcgagcgcg aggagagcct gcgccggagc cgcggtctga gtccgggtcg cgcgggagag
      241 gaactcatcg agttgcgggt gcggccggtg ctcagccggc caggttccgg tatcccgctg
      301 ccgcgcgccc tggagcgcgc tcgggcgggc gcgaagatgc aacgggacat cgaacgcgag
      361 gctcacaggc aggcggcgct ggcgagcccc gcggttccgg agcccagcgc ccggccgcgg
      421 ccgcagccgc tggatgaact caagcgcttc tttgaggctg cggcagagga cggagcgagc
      481 ttgcagcggc agccggaggc cggaggccgg ttgcaccccg cccttcagga cggctgtccg
      541 gtactggggc agttgccgcc gctcgttgct ccgtcactgc tagagcagga ggtgctccgg
      601 gtgcgtgagc gcgagcggga gctgcagctg cagcggcgca gcatctacgg ggcagccgag
      661 gaccgggagc cagcgccgag cctcacccag agcaggggag atggaaagtt ggcggtgacc
      721 tggcccccgc ggagacaggc ctcagagaac ggcctggaga aggagcgcag accctgaggt
      781 ctgtgaaggt tggggcctgc ggccagaagt aacatgccct ttggagaacc agggtagggt
      841 tatcctccag atcagcagaa ggcctagaga gggaaggccc agctttcttt aatggaaact
      901 tgaaattcag cccatccctg atactgacta tggaattaac cacctctctc cataaaagtg
      961 tttagtcttc cctggaaaat agaccaccgc ccgcaaaacc tgagtgaaac atacaataaa
     1021 gttctcctcc cttttc
//
LOCUS       NM_001106349            2290 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus TPD52 like 3 (Tpd52l3), transcript variant 1,
            mRNA.
ACCESSION   NM_001106349 XM_001079669 XM_219798
VERSION     NM_001106349.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219798.4, XM_001079669.1.
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2290
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="TPD52 like 3"
                     /db_xref="GeneID:293894"
                     /db_xref="RGD:1309391"
     exon            1..2290
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..774
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     protein D55; tumor protein D55-like; tumor protein
                     D52-like 3"
                     /codon_start=1
                     /product="tumor protein D55 isoform 1"
                     /protein_id="NP_001099819.1"
                     /db_xref="GeneID:293894"
                     /db_xref="RGD:1309391"
                     /translation="MDPSHLESHPSGQKSEPAGLDVSSTSPNCFSSNQGLDSVYQELD
                     LDSLNEDLSLSVSDAMTETSASTNEFHLASEPDLTEAEQMELRSELTKLEEEILSLRD
                     LLAAKEKRCGELKRKLGCVALVGLRQNLSKSWHDVQASNTYMKQKTSTALASMGSAIC
                     RKLGDMKKSSTFKSLEELVGTVKSRVAGGRELGSGLLPSPASGSDPHSVLGSGYETVS
                     GLDDQLFSLLKPE"
     misc_feature    310..606
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="Tumour protein D52 family; Region: TPD52;
                     pfam04201"
                     /db_xref="CDD:461225"
     misc_feature    310..606
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="Tumour protein D52 family; Region: TPD52;
                     pfam04201"
                     /db_xref="CDD:461225"
ORIGIN      
        1 gatccccatc aaaagcgtcc catcctctcg acaggacgta gacttatcaa ccagtgcctg
       61 acttttgctg cccaagatat ggacccgtct cacctcgagt cccatccctc tggccagaag
      121 tctgagcctg caggcctaga cgttagctcc accagcccta actgtttctc ctcaaaccaa
      181 ggactggatt ctgtctatca agaactggac ctggactccc tgaacgaaga tctttctttg
      241 tctgtttcag atgccatgac agagacctct gcatccacaa atgaattcca cctagcttca
      301 gaaccagatc tgacggaggc tgagcaaatg gagctcagat ctgagcttac taaattggag
      361 gaagagatct taagcttgcg tgacctgctc gcagccaaag agaagcggtg tggcgaactc
      421 aagaggaagt taggctgcgt ggccttggtg ggactgaggc agaatctgtc caagagctgg
      481 catgatgttc aggcctccaa cacctacatg aagcagaaga cttcaactgc cctggcctcg
      541 atgggttctg ccatctgcag gaagcttgga gacatgaaga agtcgtccac gttcaaatct
      601 cttgaagagc tggtggggac agtcaagtca agagtcgcgg gtggcagaga gctcggcagt
      661 ggccttcttc cttcaccagc gagtggcagc gatccacact cggttctggg gagtggatat
      721 gaaactgttt cagggcttga tgatcaactg ttttctctcc tgaagccaga gtaagccctt
      781 tgttagcctt gcttagctgc caaacctgta tatatagccc ttcttccgtc atcatacttg
      841 ccaaacaaaa acaagcaaac attgaacaat ggtaaagcta ttataattct ggacatagat
      901 acagtccagt tttgataaca agaataccca ttttgcatag atatttgctg ctcttaaatg
      961 ggaaagaagc ccaagtttga actagttatt aatactgaag tttgtagaag aaacatatct
     1021 ctatgttagc ttttctgtgg ttacttttaa tggactcagt aatggctccc agggatctta
     1081 ggccagatcc taaactcttt gaaagattag tcgattagaa ggcaaacgaa atttctatct
     1141 gggattggga aaaggtggga agtaacctgg ctagatattc tgcaagcacc attttctaca
     1201 aacaccactt gacctacaac ctttattgta gtgcagtgtt ggggatgcag tccaatgatt
     1261 cacatatcct gtacaaagtc tcctgagcta cctccctgtc accacagctt ttatttttta
     1321 aaacaatcaa gaaaactgac catcttaaag ctgccgggaa agagaaaaca tattagccac
     1381 taatcgttac tctaaagcta tacattttat aaaactttca tttttttttc aaagtggcca
     1441 attcagcaaa tcgacttagc tttaattcgg gagattatga ttttggactc aaagtgaaaa
     1501 cgctaattta cattacctgt acattttctc tatttgaata ttaaagttgt gctttaaagt
     1561 ttcacccttg aggcggcgtg tcttcaccac cagctgcatc tcattctgca gcagttgcca
     1621 attagtaacc accttccgct aagggacagg agggatacaa tgtgtccaga tttaagaact
     1681 ataagcctcc acccacctcc tcttaaacct tttgaaaaga ataccagtcc cctgtaatgc
     1741 tgactgctat gactttgaac tagccttatg gaatacacat cactcttctg gttggctcta
     1801 aacctgcctg tttttaacct caactcggaa ggaagaaccc aacccccccc aagatcaata
     1861 ggaatctgta ggaactcggt ttgagtttgt tcaagctttc ttatgtccca cttccacagg
     1921 aactgtgttt tgtttttgtt ctatgtttgt gttttgttcc ttattttcat cttttaaaat
     1981 ccccatccca gcagcttcct tctttcctcc caccacactg tctgaaatag gagctagtat
     2041 agccttgaat ggcagccgtc cactgttagc ttgggtacat ttcaataacc tgtcattgcc
     2101 tacaagtgct agtacccgat cctgtgttgc tatttcttga atgtttttct tacattcctt
     2161 ttgttctcca tagtgaaact aaatactgct gtcaatatag aagatctcgg taaactgtaa
     2221 agccattgaa aaatcccagc cctcgactga gtcccaaagg ccatgtcttg cttggattaa
     2281 aacaaattat
//
LOCUS       NM_001107372            1838 bp    mRNA    linear   ROD 03-APR-2025
DEFINITION  Rattus norvegicus potassium voltage-gated channel modifier
            subfamily G member 2 (Kcng2), transcript variant 1, mRNA.
ACCESSION   NM_001107372 XM_001058122 XM_225718
VERSION     NM_001107372.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Zhu,X.R., Netzer,R., Bohlke,K., Liu,Q. and Pongs,O.
  TITLE     Structural and functional characterization of Kv6.2 a new
            gamma-subunit of voltage-gated potassium channel
  JOURNAL   Recept Channels 6 (5), 337-350 (1999)
   PUBMED   10551266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474021.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058122.1, XM_225718.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132296,
                              SAMD00132297 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..1838
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 2"
                     /db_xref="GeneID:307234"
                     /db_xref="RGD:1309521"
     exon            1..124
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..822
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    136..138
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="upstream in-frame stop codon"
     CDS             160..1602
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="cardiac potassium channel subunit (Kv6.2);
                     voltage-gated potassium channel subunit Kv6.2; potassium
                     voltage-gated channel, subfamily G, member 2; potassium
                     channel, voltage gated modifier subfamily G, member 2"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG2"
                     /protein_id="NP_001100842.1"
                     /db_xref="GeneID:307234"
                     /db_xref="RGD:1309521"
                     /translation="MARLPGHPEVPGAEPGSAVRGGRGGRGARARHVIINVGGCRVRL
                     AWAALARCPLARLERLRACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAG
                     KLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARATPPARGPQTSP
                     GRALGSGRLERGRRRLRDVVENPHSGLAGKLFAYVSVAFVAVTAVGLCLSTMPDVRAE
                     EERGECSTKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAIIDILAILPFY
                     VSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCARE
                     FGLLLLFLCVAMALFAPLVHLAERELGAHRDFSSVPASYWWAVISMTTVGYGDMVPRS
                     LPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPVLREDSTRDD
                     STRSASATEDSSQDPETAGAAGSLPGPVGP"
     misc_feature    160..234
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    256..540
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in KCNG/Kv6
                     subfamily of potassium voltage-gated channels; Region:
                     BTB_POZ_Kv6_KCNG; cd18382"
                     /db_xref="CDD:349691"
     misc_feature    256..540
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in KCNG/Kv6
                     subfamily of potassium voltage-gated channels; Region:
                     BTB_POZ_Kv6_KCNG; cd18382"
                     /db_xref="CDD:349691"
     misc_feature    order(265..267,271..294,301..303,409..411,415..420,
                     427..429,436..438,448..450,457..459,466..468,472..474,
                     496..501,508..510)
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="putative tetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:349691"
     misc_feature    order(265..267,271..294,301..303,409..411,415..420,
                     427..429,436..438,448..450,457..459,466..468,472..474,
                     496..501,508..510)
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="putative tetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:349691"
     misc_feature    589..660
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    721..786
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    727..1446
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    727..1446
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    850..915
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    949..1011
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1048..1110
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1156..1221
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1303..1320
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
     misc_feature    1348..1434
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1444..1599
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            823..1838
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgctgga agccggagga ttgggcttgg ccgcgtgctg cgctttcatg gagcttctgg
       61 cggctgccgg aggctgggtc ttgctgccgt cccgtctggc cgcgtcggtt ctaccggagc
      121 ccgggccctg tctcctgatc gcggccggca tatggggcca tggcccggct cccggggcac
      181 ccggaggtcc ccggcgccga gcctggcagc gcagtccgag ggggccgagg cggccgcggg
      241 gcccgggcgc gccacgtcat aatcaacgtc gggggctgca gggtgcgtct ggcctgggct
      301 gcgctggccc gctgtcccct ggctcgcctc gagcgcctgc gagcctgccg cggccacgac
      361 gagctgctgc gcgtgtgtga cgactacgac gtgagccgcg acgagttctt cttcgaccgc
      421 agcccgtgcg ctttccgcgc catcgtggcg ctgctgcgcg ccggcaagct gaggctgctg
      481 cgcggcccgt gcgccctggc cttccgggac gagctggcct actggggcat cgacgaggcg
      541 cggctggagc gctgctgcct gcgccgtctg cgccgtcgcg aggaggaggc cgccgaggcg
      601 agggccacgc cgcccgcccg agggccgcag accagccccg gccgagccct ggggagcggg
      661 cggctggagc gaggccgacg gcgcctgcgc gacgtggtgg agaacccgca ctccgggctg
      721 gcgggcaagc tcttcgccta cgtctccgtg gccttcgtgg ccgtcacggc cgtgggcctg
      781 tgcctgagca ccatgcctga cgtccgcgca gaggaggaaa ggggcgagtg ctccaccaag
      841 tgccgcaacc tcttcgtgtt ggagacagtg tgcgtggcct ggttctcctt cgagttcctg
      901 ctgcgctccc tgcaagccga gagcaagtgc gccttcctcc gtacgcctct tgccatcatc
      961 gacatcctgg ccatcctgcc cttctacgtg tcgctgctcg cgggactggc cgcagggccc
     1021 acgggcagca agatgctgga acgcgcgggg ctggtactgc ggctactgcg ggcgctgcgc
     1081 gtgctctacg tgatgcgcct ggcgcgccac tcgctggggc tacgctcgct tggcctcacc
     1141 gtgcgccgct gcgcgcgcga gttcggactg ctgctgctct tcctctgcgt ggccatggcg
     1201 ctcttcgcgc cgctcgtgca cctggctgag cgcgagctgg gcgctcaccg cgacttctcc
     1261 agcgtccccg ccagctactg gtgggcagtc atctccatga ccaccgtggg ctatggagac
     1321 atggtgccac gcagccttcc gggccaggtg gtggcgctga gcagcatcct cagcggcatc
     1381 ctgctcatgg ccttccctgt cacctccatc ttccacacct tctcgcgctc ctactcggag
     1441 ctcaaggagc agcagcaacg cgcggccagc cctgaaccgg tcctgcggga ggacagcaca
     1501 cgcgacgaca gcacgcgttc ggccagcgcc accgaggaca gctcccagga cccggagacc
     1561 gcaggtgccg cagggagctt gccaggcccg gtgggaccct gagctgtact gagaacttca
     1621 gagtcaaagc ctcagaggac accaagcgct ggctgaccca ggagtcgcaa acttggcctg
     1681 gcatgtcgtc gttgcagctg ccttggctcc cccaagcaac cccgagcttc gcgtagcctg
     1741 gaggagatcg caacctggtc tttctttttc cttttatttt tccctccagt tttaaatttt
     1801 ctatggttaa ttaaaaattg agtcccagaa attccaag
//
LOCUS       NM_001106363            5092 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 2, mRNA.
ACCESSION   NM_001106363 XM_001065637 XM_215259
VERSION     NM_001106363.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced NM_001106363.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.6317.1,
                                           SRR26643296.4637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3645           JAXUCZ010000001.1  254862692-254862762
            3646-4363           JAXUCZ010000001.1  254863590-254864307
            4364-4501           JAXUCZ010000001.1  254865878-254866015
            4502-4568           JAXUCZ010000001.1  254866108-254866174
            4569-4690           JAXUCZ010000001.1  254866293-254866414
            4691-4842           JAXUCZ010000001.1  254866843-254866994
            4843-5092           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5092
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4946
                     /gene="Pprc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 2"
                     /protein_id="NP_001099833.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSIDTPQEKKPLDRLHAPELANV
                     AGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGV
                     RGPSPVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAA
                     PPLPCTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQ
                     RSMRCYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSL
                     SPPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYSS
                     YRSNDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRV
                     QGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNRED
                     FDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4112
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4112
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4572..4844
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4572..4844
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3645
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..4363
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4501
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4568
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4569..4690
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4842
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..5092
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact caggcagcat tgacactccc caggagaaga
     3601 aacccctaga ccggttacac gccccagaac tggccaacgt ggcagggctc accccgccag
     3661 ctacccctcc ccaccagtta tggaaacccc tggctgctgt ctcactgttg gccaaagcca
     3721 aatctcctaa atctactgcc caagagggaa ccctgaagcc tgaaggaatt acagaggcca
     3781 aacctccagc tgcagcctgc ctccaagaag gggtccgtgg ccctagtcca gtccatgtgg
     3841 gctctgggga ccatgactat tgtgtccgaa gcaggacacc cccaaaaaag atgcctgccc
     3901 tagtcatttc agagatgggc tctcgatgga atgtcaagcg ccatcaggac atcactatca
     3961 aacctgtctt gtcattgggc tcagctgccc ccccactccc atgcacaacc acttcccagg
     4021 aaccgcttga tcacaggact agcagtgagc aggcagatcc gtcagcgcct tgttttgccc
     4081 catccacctt gctgtctcct gaggcctcac cctgccggaa tgaaatgaac actaggactc
     4141 cctctgagcc cccagacaag cagcggtcaa tgcgctgtta ccgaaaagcc tgcagatcag
     4201 ccagcccccc aagtcggggc tggcaaggcc gccgtggccg tagcagccgt tctgtcagct
     4261 ctgggtccag ccggaccagt gaagcatcct catcctcatc ggtgtcttcc tcatcccggt
     4321 cccggtccag gtccctctcc cccccaaaca agaggtggcg aaggtccagc tgcagttcct
     4381 ctggacggtc cagaagatgt tcctcctctt cctcttcttc ctcctcctca tcttcatcat
     4441 ccagttccag aagccggtct ccctctgtgt ccccttgcag gagaagtgac cggaggcggc
     4501 ggtacagctc ttaccgttca aatgaccatt accaaaggca gagagtactg cagaaggagc
     4561 gtgcaataga agagagaagg gtggtcttca ttgggaaaat acctggccgc atgactcggt
     4621 cggagctgaa gcagaggttc tctgtttttg gagagattga ggagtgtacc attcattttc
     4681 gtgtccaagg tgacaactat ggtttcgtca cttaccggta tgctgaagag gcatttgcag
     4741 ccattgagag tggccacaag ttgcggcagg cagacgagca gccctttgat ctctgctttg
     4801 ggggccgaag gcagttctgc aagaggagtt actctgatct tgactccaat cgggaagact
     4861 ttgatcctgc tcctgtcaag agcaaattcg attctcttga ctttgatact ttgttgaaac
     4921 aggcccagaa gaacctaagg aggtaaccct gggctttcct cccccatcca ttttctctgg
     4981 aggtgtccaa cctctcaacc ccctccccta ctctagggga gagagctgct agtgtggaaa
     5041 gacttttata aggaaatgaa aaaaagttaa ataaaaatat gttaaatcgg ga
//
LOCUS       NM_001437554            5080 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 6, mRNA.
ACCESSION   NM_001437554 XM_063287203
VERSION     NM_001437554.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287203.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.192428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-596             JAXUCZ010000001.1  254857203-254857295
            597-3453            JAXUCZ010000001.1  254857400-254860256
            3454-3507           JAXUCZ010000001.1  254860529-254860582
            3508-3565           JAXUCZ010000001.1  254861917-254861974
            3566-3633           JAXUCZ010000001.1  254862695-254862762
            3634-4351           JAXUCZ010000001.1  254863590-254864307
            4352-4489           JAXUCZ010000001.1  254865878-254866015
            4490-4556           JAXUCZ010000001.1  254866108-254866174
            4557-4678           JAXUCZ010000001.1  254866293-254866414
            4679-4830           JAXUCZ010000001.1  254866843-254866994
            4831-5080           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5080
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4934
                     /gene="Pprc1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 6"
                     /protein_id="NP_001424483.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVEMSLADSPWDFSPPPFLETSSPKLPSWR
                     SSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPEEED
                     KSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLPEGC
                     VVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGTEDG
                     VPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKKKKK
                     EQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGKPRA
                     WARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSARAD
                     SIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVAIPT
                     SNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPSLEP
                     SDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDRNSQ
                     PPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSPTPE
                     PSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLPPLL
                     PLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYSCLP
                     PPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPFWST
                     VSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAEPTK
                     LEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRPREK
                     PISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGIEAS
                     DLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGIDTPQEKKPLDRLHAPELANVAGLT
                     PPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGVRGPS
                     PVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAAPPLP
                     CTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQRSMR
                     CYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSLSPPN
                     KRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYSSYRSN
                     DHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDN
                     YGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPA
                     PVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1152..2549
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1152..2549
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1908..3365
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1908..3365
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2949..4100
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2949..4100
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4560..4832
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4560..4832
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..596
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..3453
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3507
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3565
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3633
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..4351
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4489
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4556
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4678
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4830
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..5080
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggttg
      601 agatgtccct tgcagattct ccgtgggact tctctccacc tcctttcttg gaaacttctt
      661 cccctaagct gcctagctgg agatcctcaa gaccaagacc tcgatggagt cagtctcctc
      721 ctccccagca gcgcagtgat ggagaggagg aggaagaggt tgccggcttc agtggtcaga
      781 tgcttgatgg cgaacttgac aactcggtga ataccttgga tttccccatg cacctggcat
      841 gccctgagga agaagacaag tcaggggcag caaatgtggc agtgtcagca cctggtgacg
      901 agagcatctc ctccttgagt gagctggtac gggccatgca cccctactgc ttacccaacc
      961 tcacccagtt ggcatcactt gacgctgagc ttcaggagca ggctgatgat ctgacactgc
     1021 ctgagggttg tgtggtgctg gagattgtgg gccaggcagc cacagctggt gatgacctgg
     1081 agatcccagt ggtcgtgcgg cagattcctt caggatccca gtctgtgctc ctagatgggt
     1141 ctgtagggac tgatcctgcc ttgcagctac tcatgcccgc catggagcct ggaacagaag
     1201 atggtgtgcc taaagtcgct ccttgccctg atcaagaatt accactgagc tctgcctgct
     1261 tattggagcc cagggacatc atggagtcat tggcccccaa ggagcctcgg aacctacctg
     1321 ccaatgcaag tgagggttct cagagagttc ccagaaaggg taggaagaag aagaagaagg
     1381 agcagccaac agcctgtttg gaaggctgta ccaggaggct gaggtcatct tctcgtggac
     1441 agtctactgt ggctacagag gtgaactctc aggcaggcaa cttacagaaa cagcctcagg
     1501 aagagcttca gagagagact gcggcccctc agagcagagg gaagccacgg gcttgggctc
     1561 gggcctgggc agctgccttg gagaaaactg ggtctgaaga cccagaggac cagaatgcag
     1621 gacaggatag tcctgctgag gaagatgttc tagaactccg tcctaagctg gtggagacta
     1681 gccaagccga ccccacgctc tcactaaacg actctgctcg agctgactcc atcccagtta
     1741 actctgttga aggtgactcc actgcagtgg acactgctgt acctgttgac caggcttcat
     1801 cttgtacaga gctggttggt tctctctcag gaggcccaat tctgagtagc ccagtcctag
     1861 atgacaggac aggagttgaa cctgcagtgg ctattcccac ttcaaatcac ttgtctccag
     1921 ctgatgctat cctagctaac ccagggacag ctgaccctgc tccaaatggc ctggctccag
     1981 gagatcctgt gctagttaag tgcagaccaa ctgatcctag acgtgcagct gctgctgcca
     2041 ctgctgctca ggggcctcgt ccttccctag agccctcaga ccatcctaag gtcatcaccc
     2101 ctgaagtcaa ggatgctgga ggtcctctga aggtggaagg tagtaccagt gctacaaccc
     2161 aggaagccag acctcggccc ctcagcctat ctgagtaccg tcaacgacgg cggcaacggc
     2221 aaatagaagc agaagacagg aattctcagc ccccagctgg aaagtggcca agtctcccag
     2281 agacgcccaa agggctggca gatatccctt gtcttgttcc atcagcccca accaagaaga
     2341 cagccccaca gagaagccct atagctgtac cagagacttg ttctgtatct gtgggttcta
     2401 accctgtttc ccctactcct gagccatctg caagcaaact tatggtttca actcactctg
     2461 aacaggtgtc atctcatgag atgccacttc cagttagact tccccctcct acattgcagt
     2521 ctatggctcc tgctgggccc accccttcta cagtgcccac gccattgcct ttccctccga
     2581 gcttacctcc tctgcttcct cttcctgcaa gtggtcctgg tgtccccagc ctgcccccac
     2641 ctcctttgca acctcctgga cttccagtat caatgagaca aatgccacct gacccctata
     2701 ctcagtatgc ccctgtgccg ccctggcctt gttacccctc tgtatctcct tctggctatt
     2761 cttgtctgcc cccaccacca gcgatgccca tagtgtcggg tacccctggt acctatgctg
     2821 tacccccaac ttgcaatgtg ccttgggtac cccctcctgc accagtctca ccttatagct
     2881 ccagctctgc ctatgggtcc cttgggtggg gcccagggtt gcaacagcct cccttttggt
     2941 ctactgtttc tccacctcca ttgtcttcag cctctactgg tagagctgtt cccccaccca
     3001 gtgtggaacc cagtaacagt tcagctggtc ctccggaaga tacacttcct gtgccagtga
     3061 ccccttccct gagctctcgg ccagccagcc ccatagctcc accagcagaa cctacgaagc
     3121 tggaggctca gccagtgcct gtctctcccc aaccgaaaca caaagtgtcc cctgtggtac
     3181 agagtcccca gatcaaggtt ctaccaactc tgtctgctga gggcgtggct attggggaat
     3241 ctgaatcaga gaggctaaag ccggagaccc aggagaacag accaagggag aagcctatct
     3301 ctacggctac gaaggctgtt ctgttaccaa agcagagcac tgtcgcaaaa ctgcctgccg
     3361 tccatccagc ccggctaagg aggctgtcct tcctgcccac cccacgtgct cagggttctg
     3421 aggatgtggt gcaggcattc atcagtgaga ttgggattga agcatcagac ctgtccagtc
     3481 tgttggagca gtttgagaaa tcagaagcca aaaaggagtg tcctctcccg gctcctgctg
     3541 acagcgtggc tgtaggaaac tcaggcattg acactcccca ggagaagaaa cccctagacc
     3601 ggttacacgc cccagaactg gccaacgtgg cagggctcac cccgccagct acccctcccc
     3661 accagttatg gaaacccctg gctgctgtct cactgttggc caaagccaaa tctcctaaat
     3721 ctactgccca agagggaacc ctgaagcctg aaggaattac agaggccaaa cctccagctg
     3781 cagcctgcct ccaagaaggg gtccgtggcc ctagtccagt ccatgtgggc tctggggacc
     3841 atgactattg tgtccgaagc aggacacccc caaaaaagat gcctgcccta gtcatttcag
     3901 agatgggctc tcgatggaat gtcaagcgcc atcaggacat cactatcaaa cctgtcttgt
     3961 cattgggctc agctgccccc ccactcccat gcacaaccac ttcccaggaa ccgcttgatc
     4021 acaggactag cagtgagcag gcagatccgt cagcgccttg ttttgcccca tccaccttgc
     4081 tgtctcctga ggcctcaccc tgccggaatg aaatgaacac taggactccc tctgagcccc
     4141 cagacaagca gcggtcaatg cgctgttacc gaaaagcctg cagatcagcc agccccccaa
     4201 gtcggggctg gcaaggccgc cgtggccgta gcagccgttc tgtcagctct gggtccagcc
     4261 ggaccagtga agcatcctca tcctcatcgg tgtcttcctc atcccggtcc cggtccaggt
     4321 ccctctcccc cccaaacaag aggtggcgaa ggtccagctg cagttcctct ggacggtcca
     4381 gaagatgttc ctcctcttcc tcttcttcct cctcctcatc ttcatcatcc agttccagaa
     4441 gccggtctcc ctctgtgtcc ccttgcagga gaagtgaccg gaggcggcgg tacagctctt
     4501 accgttcaaa tgaccattac caaaggcaga gagtactgca gaaggagcgt gcaatagaag
     4561 agagaagggt ggtcttcatt gggaaaatac ctggccgcat gactcggtcg gagctgaagc
     4621 agaggttctc tgtttttgga gagattgagg agtgtaccat tcattttcgt gtccaaggtg
     4681 acaactatgg tttcgtcact taccggtatg ctgaagaggc atttgcagcc attgagagtg
     4741 gccacaagtt gcggcaggca gacgagcagc cctttgatct ctgctttggg ggccgaaggc
     4801 agttctgcaa gaggagttac tctgatcttg actccaatcg ggaagacttt gatcctgctc
     4861 ctgtcaagag caaattcgat tctcttgact ttgatacttt gttgaaacag gcccagaaga
     4921 acctaaggag gtaaccctgg gctttcctcc cccatccatt ttctctggag gtgtccaacc
     4981 tctcaacccc ctcccctact ctaggggaga gagctgctag tgtggaaaga cttttataag
     5041 gaaatgaaaa aaagttaaat aaaaatatgt taaatcggga
//
LOCUS       NM_001437569            1480 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), transcript
            variant 4, mRNA.
ACCESSION   NM_001437569 XM_006231474
VERSION     NM_001437569.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006231474.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.762836.1,
                                           SRR26360190.690026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  256370562-256370776 c
            216-391             JAXUCZ010000001.1  256369932-256370107 c
            392-487             JAXUCZ010000001.1  256363461-256363556 c
            488-556             JAXUCZ010000001.1  256358861-256358929 c
            557-724             JAXUCZ010000001.1  256351463-256351630 c
            725-848             JAXUCZ010000001.1  256350493-256350616 c
            849-1017            JAXUCZ010000001.1  256348306-256348474 c
            1018-1137           JAXUCZ010000001.1  256344882-256345001 c
            1138-1210           JAXUCZ010000001.1  256342471-256342543 c
            1211-1480           JAXUCZ010000001.1  256336916-256337185 c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1480
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..215
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..391
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    232..234
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="upstream in-frame stop codon"
     CDS             238..1368
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 1; CST complex subunit STN1; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide-binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1 isoform 2"
                     /protein_id="NP_001424498.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNKDTLDLAGLTALLS
                     EKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVFK
                     NALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNHVEKGCHLMH
                     VLNCVLLNLRWDLNKAVLQQVLELLEDQSDIVSTGDHYYTAF"
     misc_feature    430..732
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    430..732
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    order(430..432,658..660,664..666,670..672,724..726)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(430..432,658..660,664..666,670..672,724..726)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(445..453,478..489,493..495,511..519,523..525,
                     655..657,676..684,703..711)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(445..453,478..489,493..495,511..519,523..525,
                     655..657,676..684,703..711)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    868..1365
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    868..1365
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     exon            392..487
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..556
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..724
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..848
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1017
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1137
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1210
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1480
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcgcaa ccggaactat ttcggcaatc ttggccaact gctcctgctc cgggagaggc
       61 tgtaaaccgc tctgattctg cctccttttc ctttcctccg ctcttcccag aaggtgaaat
      121 gtcgaagagt ggatagacac acctccaggg cccaaagtcc acggccacag gggcgccatt
      181 cactctccgg actcattcgt taaaactcct ttgggagtct tggctcaggg ttagcagatg
      241 ccagaacctt gccttttgat gcagtgcgaa tccagtccaa aagaagagga gatcccgtcc
      301 ctcttttggg gtctggatcc cgtgtttcta gcctttgcaa aactctacat caaggacatc
      361 ctggagatga aggagtccca acaagtgcca ggcatgtatt tttacaatgg acatccaata
      421 agacgggtgg atatcatggg agctgtcatc agtgtgaaag agagagagac tttctacagc
      481 tatggagtgg atgacgccac aggggttata aactgtgtgt gctggaaaag gccaagcaat
      541 gccgagtctt catcagaccc agctattctg agcacttcga gagaactcag catgacctca
      601 cagcttaaga aactgcagga gaccattgag cagaaaacca agatcgggat tggggatatc
      661 atccgagtcc gaggctacgt gcgtatgttc cgagaagagc gagagatctg tgccaccatt
      721 tattataagg tggacgatcc agtgtggaac atgcaaattg caaggatgct tgagctgcca
      781 gagctctaca agaaggtgta tgaccagccc ttccggaacc cagccctaaa ggaggaagag
      841 gcactaaata aagacacttt ggatctcgct ggcctcacgg ctttgttgag tgagaaagtt
      901 aaagaatttc tccaggagaa gaaagtgcaa agcttctacc agaaggagct ggaaatggtg
      961 gagcccttgc agtctctggc cagtcagccc gtgacccaca gcacgtgctc ggaccaagtg
     1021 gagttaaaga acgacgccgc ttctgacata cacagtgtgt ttaagaatgc tctgcacctg
     1081 cttcaggaaa aggggttcgt gttccagaga gacggtggct ccgataagct gtactatgtt
     1141 accagtaagg acaaagacct gcaccagaag atctaccaga tcattaagga agactgtcag
     1201 aaaccaaatc atgtggagaa gggctgccac ttgatgcacg tcctgaactg cgtgctcctc
     1261 aacctccgct gggacctgaa caaggctgtg ctgcagcagg tgctggagct cctggaggac
     1321 cagagcgaca ttgtgagtac tggagaccac tactacacgg ccttctgagc agagccacgg
     1381 agaggcagca ggcagcttta ccccaggttc tgctcccagg cgttgtagag acttatttgt
     1441 gtataatccc ctaataaagt ctgatacagc cacaggaaaa
//
LOCUS       NM_001437556            4297 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 8, mRNA.
ACCESSION   NM_001437556 XM_063287217
VERSION     NM_001437556.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287217.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.4653.1,
                                           SRR26360172.1522454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3712           JAXUCZ010000001.1  254865878-254866015
            3713-3773           JAXUCZ010000001.1  254866114-254866174
            3774-3895           JAXUCZ010000001.1  254866293-254866414
            3896-4047           JAXUCZ010000001.1  254866843-254866994
            4048-4297           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4297
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4151
                     /gene="Pprc1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 8"
                     /protein_id="NP_001424485.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSSCSSSGRSRRCSSSSSSSSSS
                     SSSSSSRSRSPSVSPCRRSDRRRRSYRSNDHYQRQRVLQKERAIEERRVVFIGKIPGR
                     MTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQP
                     FDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3777..4049
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    3777..4049
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3712
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3773
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3895
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4047
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4297
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact cagggtccag ctgcagttcc tctggacggt
     3601 ccagaagatg ttcctcctct tcctcttctt cctcctcctc atcttcatca tccagttcca
     3661 gaagccggtc tccctctgtg tccccttgca ggagaagtga ccggaggcgg cgctcttacc
     3721 gttcaaatga ccattaccaa aggcagagag tactgcagaa ggagcgtgca atagaagaga
     3781 gaagggtggt cttcattggg aaaatacctg gccgcatgac tcggtcggag ctgaagcaga
     3841 ggttctctgt ttttggagag attgaggagt gtaccattca ttttcgtgtc caaggtgaca
     3901 actatggttt cgtcacttac cggtatgctg aagaggcatt tgcagccatt gagagtggcc
     3961 acaagttgcg gcaggcagac gagcagccct ttgatctctg ctttgggggc cgaaggcagt
     4021 tctgcaagag gagttactct gatcttgact ccaatcggga agactttgat cctgctcctg
     4081 tcaagagcaa attcgattct cttgactttg atactttgtt gaaacaggcc cagaagaacc
     4141 taaggaggta accctgggct ttcctccccc atccattttc tctggaggtg tccaacctct
     4201 caaccccctc ccctactcta ggggagagag ctgctagtgt ggaaagactt ttataaggaa
     4261 atgaaaaaaa gttaaataaa aatatgttaa atcggga
//
LOCUS       NM_001108334            8743 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus nuclear receptor co-repressor 2 (Ncor2),
            transcript variant 2, mRNA.
ACCESSION   NM_001108334 XM_001074041 XM_341072
VERSION     NM_001108334.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8743)
  AUTHORS   Barbieri,C.E., Bangma,C.H., Bjartell,A., Catto,J.W., Culig,Z.,
            Gronberg,H., Luo,J., Visakorpi,T. and Rubin,M.A.
  TITLE     The mutational landscape of prostate cancer
  JOURNAL   Eur Urol 64 (4), 567-576 (2013)
   PUBMED   23759327
  REMARK    Review article
REFERENCE   2  (bases 1 to 8743)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   3  (bases 1 to 8743)
  AUTHORS   Pei,L., Leblanc,M., Barish,G., Atkins,A., Nofsinger,R., Whyte,J.,
            Gold,D., He,M., Kawamura,K., Li,H.R., Downes,M., Yu,R.T.,
            Powell,H.C., Lingrel,J.B. and Evans,R.M.
  TITLE     Thyroid hormone receptor repression is linked to type I
            pneumocyte-associated respiratory distress syndrome
  JOURNAL   Nat Med 17 (11), 1466-1472 (2011)
   PUBMED   22001906
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8743)
  AUTHORS   Sircoulomb,F., Nicolas,N., Ferrari,A., Finetti,P., Bekhouche,I.,
            Rousselet,E., Lonigro,A., Adelaide,J., Baudelet,E., Esteyries,S.,
            Wicinski,J., Audebert,S., Charafe-Jauffret,E., Jacquemier,J.,
            Lopez,M., Borg,J.P., Sotiriou,C., Popovici,C., Bertucci,F.,
            Birnbaum,D., Chaffanet,M. and Ginestier,C.
  TITLE     ZNF703 gene amplification at 8p12 specifies luminal B breast cancer
  JOURNAL   EMBO Mol Med 3 (3), 153-166 (2011)
   PUBMED   21328542
  REMARK    Erratum:[EMBO Mol Med. 2011 Mar;3(3). doi:10.1002/emmm.201000121]
REFERENCE   5  (bases 1 to 8743)
  AUTHORS   Cui,J., Yang,Y., Zhang,C., Hu,P., Kan,W., Bai,X., Liu,X. and
            Song,H.
  TITLE     FBI-1 functions as a novel AR co-repressor in prostate cancer cells
  JOURNAL   Cell Mol Life Sci 68 (6), 1091-1103 (2011)
   PUBMED   20812024
REFERENCE   6  (bases 1 to 8743)
  AUTHORS   Martinez de Arrieta,C., Koibuchi,N. and Chin,W.W.
  TITLE     Coactivator and corepressor gene expression in rat cerebellum
            during postnatal development and the effect of altered thyroid
            status
  JOURNAL   Endocrinology 141 (5), 1693-1698 (2000)
   PUBMED   10803578
REFERENCE   7  (bases 1 to 8743)
  AUTHORS   Zhou,S., Fujimuro,M., Hsieh,J.J., Chen,L., Miyamoto,A.,
            Weinmaster,G. and Hayward,S.D.
  TITLE     SKIP, a CBF1-associated protein, interacts with the ankyrin repeat
            domain of NotchIC To facilitate NotchIC function
  JOURNAL   Mol Cell Biol 20 (7), 2400-2410 (2000)
   PUBMED   10713164
REFERENCE   8  (bases 1 to 8743)
  AUTHORS   Park,E.J., Schroen,D.J., Yang,M., Li,H., Li,L. and Chen,J.D.
  TITLE     SMRTe, a silencing mediator for retinoid and thyroid hormone
            receptors-extended isoform that is more related to the nuclear
            receptor corepressor
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3519-3524 (1999)
   PUBMED   10097068
REFERENCE   9  (bases 1 to 8743)
  AUTHORS   Ordentlich,P., Downes,M., Xie,W., Genin,A., Spinner,N.B. and
            Evans,R.M.
  TITLE     Unique forms of human and mouse nuclear receptor corepressor SMRT
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2639-2644 (1999)
   PUBMED   10077563
REFERENCE   10 (bases 1 to 8743)
  AUTHORS   Misiti,S., Schomburg,L., Yen,P.M. and Chin,W.W.
  TITLE     Expression and hormonal regulation of coactivator and corepressor
            genes
  JOURNAL   Endocrinology 139 (5), 2493-2500 (1998)
   PUBMED   9564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 4, 2025 this sequence version replaced NM_001108334.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000012.1  37127735-37127957
            224-434             JAXUCZ010000012.1  37181505-37181715
            435-562             JAXUCZ010000012.1  37186661-37186788
            563-740             JAXUCZ010000012.1  37187461-37187638
            741-920             JAXUCZ010000012.1  37195992-37196171
            921-1034            JAXUCZ010000012.1  37199919-37200032
            1035-1091           JAXUCZ010000012.1  37203554-37203610
            1092-1144           JAXUCZ010000012.1  37208308-37208360
            1145-1211           JAXUCZ010000012.1  37214776-37214842
            1212-1384           JAXUCZ010000012.1  37218299-37218471
            1385-1478           JAXUCZ010000012.1  37219313-37219406
            1479-1657           JAXUCZ010000012.1  37221026-37221204
            1658-1712           JAXUCZ010000012.1  37224761-37224815
            1713-1811           JAXUCZ010000012.1  37226642-37226740
            1812-1957           JAXUCZ010000012.1  37236904-37237049
            1958-2130           JAXUCZ010000012.1  37238062-37238234
            2131-2193           JAXUCZ010000012.1  37240123-37240185
            2194-2336           JAXUCZ010000012.1  37249760-37249902
            2337-2484           JAXUCZ010000012.1  37254466-37254613
            2485-2538           JAXUCZ010000012.1  37256119-37256172
            2539-3136           JAXUCZ010000012.1  37257021-37257618
            3137-3257           JAXUCZ010000012.1  37262715-37262835
            3258-3426           JAXUCZ010000012.1  37263591-37263759
            3427-3591           JAXUCZ010000012.1  37266394-37266558
            3592-3728           JAXUCZ010000012.1  37267421-37267557
            3729-3834           JAXUCZ010000012.1  37268044-37268149
            3835-3932           JAXUCZ010000012.1  37268502-37268599
            3933-4083           JAXUCZ010000012.1  37270589-37270739
            4084-4224           JAXUCZ010000012.1  37272343-37272483
            4225-4305           JAXUCZ010000012.1  37272774-37272854
            4306-4601           JAXUCZ010000012.1  37273219-37273514
            4602-4956           JAXUCZ010000012.1  37274441-37274795
            4957-5178           JAXUCZ010000012.1  37275932-37276153
            5179-5433           JAXUCZ010000012.1  37276604-37276858
            5434-5583           JAXUCZ010000012.1  37277625-37277774
            5584-5715           JAXUCZ010000012.1  37277883-37278014
            5716-5902           JAXUCZ010000012.1  37278098-37278284
            5903-6318           JAXUCZ010000012.1  37279776-37280191
            6319-6471           JAXUCZ010000012.1  37281155-37281307
            6472-6617           JAXUCZ010000012.1  37281397-37281542
            6618-6811           JAXUCZ010000012.1  37281763-37281956
            6812-6958           JAXUCZ010000012.1  37282623-37282769
            6959-7104           JAXUCZ010000012.1  37283278-37283423
            7105-7158           JAXUCZ010000012.1  37283997-37284050
            7159-7386           JAXUCZ010000012.1  37286783-37287010
            7387-7566           JAXUCZ010000012.1  37287848-37288027
            7567-8743           JAXUCZ010000012.1  37288437-37289613
FEATURES             Location/Qualifiers
     source          1..8743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..8743
                     /gene="Ncor2"
                     /note="nuclear receptor co-repressor 2"
                     /db_xref="GeneID:360801"
                     /db_xref="RGD:1310293"
     exon            1..223
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..434
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    231..233
                     /gene="Ncor2"
                     /note="upstream in-frame stop codon"
     CDS             330..7748
                     /gene="Ncor2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear receptor corepressor 2"
                     /codon_start=1
                     /product="nuclear receptor corepressor 2 isoform 2"
                     /protein_id="NP_001101804.1"
                     /db_xref="GeneID:360801"
                     /db_xref="RGD:1310293"
                     /translation="MSGSTQPVAQTWRAAEPRYPPHGISYPVQIARPHTDVGLLEYQH
                     HPRDYTSHLSPGSIIQPQRRRPSLLSEFQPGSERSQELHLRPESRTFLPELGKPDIEF
                     TESKRPRLELLPDTLLRPAPLLATGQPSGSEDLTKDRSLAGKLEPVSPPSPPHADPEL
                     ELTPSRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPP
                     IESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAM
                     RKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYE
                     KQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQL
                     AVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKN
                     FGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQM
                     ARSSQEEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVASKGRK
                     TANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAKKGLL
                     EHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKT
                     PAAASEETAFPPAAEDEEMEASGASANEEELAEEAEASQASGNEVPRVGECSGPAAVN
                     NSSDTESVPSPRTEATKDAGPKPASTEALPAATQPPVPPPEEPATVPDEPCPAPDASG
                     PPSPVASPPPAAPPAAVDKDEQDQAATVPQTEDAKEQKSEAEELVIDVGKTEEPEAPE
                     EPPESVKSDHKEETEEEPEDKAKGPEAIETVSEAPLKVEEAGSKAAVTKGSSSGATQD
                     SDSSATCSADEVDEPEGGDKGRLLSPRPSLLTPAGDPRASTSPQKPLDLKQLKQRAAA
                     IPPIVTKVHEPPREDTVPPKPAPPVPPPTQHLQPEGDVSQQSGGSPRGKCRSPVPPAE
                     KEAEKASFFPAFPAEGPKLPTEPPRWTSGLPFPIPPREVIKTSPHAADPSAFSYTPPG
                     HPLPLGLHDSARPVLPRPPISNPPPLISSAKHPGVLERQLGTISQQGMSVQLRVPHSE
                     HAKAPMGPLTMGLPLAVDPKKLGTALGSTASGSITKGLPSTRTADGPSYRGSITHGTP
                     ADVLYKGTISRIVGEDSPSRLDRAREDTLPKGHVIYEGKKGHVLSYEGGMSVSQCSKE
                     DGRSSSGPPHETAAPKRTYDMMEGRVGRTITSASIEGLMGRAIPEQHSPHLKEQHHIR
                     GSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPPRDLTETYKTRPLDPLGPLKL
                     KPTHEGVVATVKEAGRSIHEIPREELRRTPELPLAPRPLKEGSITQGTPLKYDSGVPS
                     SGSKKHDVRSIIGSPGRPFPALHPLDIMADARALERACYEESLKSRSGTSSGAGGSIT
                     RGAPVVVPELGKPRQSPLAYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQ
                     DRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVTGVDLYRGHIPLAFDPTSIPR
                     GIPLEAAAAAYYLPRHLAPSPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMH
                     HNAASAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATA
                     IDRLAYLPTAPPPFSSRHSSSPLSPGGPTHLAKPTATSSSERERERERERDKSILTST
                     TTVEHAPIWRPGTEQSSGAGGSSRPASHTHQHSPISPRTQDALQQRPSVLHNTSMKGV
                     VTSVEPGTPTVLRWARSTSTSSPVRPAATFPPATHCPLGGTLEGVYPTLMEPVLLPKE
                     TSRVTRPERPRVDAGHAFLTKPPAREPASSPSKSSEPRSLAPPSSSHTAIARTPAKSL
                     APHHASPDLPAPTSASDLHREKTQSKPFSIQELELRSLGYHSGAGYSPDGVEPISPVS
                     SPSLTHDKGLSKPLEELEKSHLEGELRHKQPGPMKLSGEAAHLPHLRPLPESQPSSSP
                     LLQTAPGIKGHQRVVTLAQHISEVITQDYTRHHPQQLSGPLPAPLYSFPGASCPVLDL
                     RRPPSDLYLPPPDHGTPARGSPHSEGGKRSPEPSKTVLSSSEDAIEPVSPPEGMTEPG
                     HARSTAYPLLYRDGEQGEPRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKL
                     NTHNRNEPEYNIGQPGTEIFNMPAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMG
                     KYDQWEEPPPLGANAFNPLNASASLPAAAMPITTADGRSDHPLTSPGGGGKAKVSGRP
                     SSRKAKSPAPGLAPGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPL
                     IMRLQAGVMASPPPPGLAAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE"
     misc_feature    756..1016
                     /gene="Ncor2"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     Region: GPS2_interact; pfam15784"
                     /db_xref="CDD:464868"
     misc_feature    756..1016
                     /gene="Ncor2"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     Region: GPS2_interact; pfam15784"
                     /db_xref="CDD:464868"
     misc_feature    <834..2210
                     /gene="Ncor2"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <834..2210
                     /gene="Ncor2"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    1623..1754
                     /gene="Ncor2"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl21498"
                     /db_xref="CDD:473887"
     misc_feature    1623..1754
                     /gene="Ncor2"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl21498"
                     /db_xref="CDD:473887"
     misc_feature    order(1623..1625,1710..1715,1719..1724,1728..1736,
                     1740..1748)
                     /gene="Ncor2"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1623..1625,1710..1715,1719..1724,1728..1736,
                     1740..1748)
                     /gene="Ncor2"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    2157..2288
                     /gene="Ncor2"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-binding; pfam00249"
                     /db_xref="CDD:459731"
     misc_feature    2157..2288
                     /gene="Ncor2"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-binding; pfam00249"
                     /db_xref="CDD:459731"
     misc_feature    <5487..7001
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5487..7001
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            435..562
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..740
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..920
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1034
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1091
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1144
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1211
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1384
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1478
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1657
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1712
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1811
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1957
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2130
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2193
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2336
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2484
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2538
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..3136
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3257
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3426
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3591
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3728
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3834
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3932
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4083
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4224
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4305
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4601
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4956
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4957..5178
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5179..5433
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5583
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5584..5715
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5716..5902
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5903..6318
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6319..6471
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6472..6617
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6618..6811
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6812..6958
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6959..7104
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7105..7158
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7159..7386
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7387..7566
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7567..8743
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccagga gcggagccgc gggcagcgca ggccgggccg catccccgta cccgcgccag
       61 ccgcccgcgc ccgccatgcg cgccccgcag cggcccgcgc gcccgggccc cgcgtcgtag
      121 cgcggcgggc ggagaccgca ggctcctagc cggtgcccgc cgcgtcctcg agcccgatcg
      181 gcgccgtagc ccggcgccag cgcccggtgc cgccgccggc gaggtacctg tgacgaggtc
      241 accggccagc agatgaccga gaccagcccc tagtcctagg tgtggtcaag agtgtattgg
      301 gttccaaagc cttcctggac cctaccacca tgtcaggatc cacacagcct gtggcacaga
      361 catggcgggc tgctgagccc cgctacccac cccatggcat ctcctacccg gtgcagatag
      421 cccggcccca cacggacgtg gggctgcttg agtaccaaca ccaccctcgt gactacacct
      481 cacacctgtc acccggctcc attatccagc cacagaggag gcggccctca ctgctatctg
      541 agttccagcc tggaagtgaa cggtctcagg agctccacct gcgccctgag tctcgcacct
      601 tcctgcctga actgggcaag cccgacatag aattcacaga gagcaagcgc ccacgcctgg
      661 agctactacc tgataccctg ctgcgcccgg cacccctgct ggccactggg cagccaagtg
      721 ggtctgaaga tcttaccaag gaccgcagcc tggcaggcaa gctggagccc gtgtcacctc
      781 ccagcccacc acacgctgac cctgagctag agctgacgcc atctcggctg tccaaggagg
      841 agctgatcca gaacatggac cgtgtggacc gtgagatcac catggtggag cagcagatct
      901 ccaagctgaa gaagaagcag caacagttgg aggaggaggc cgccaagcca cccgagcccg
      961 agaagccggt gtcgccacca cccatagaat caaagcaccg cagtctggtc cagatcatct
     1021 acgacgagaa ccggaagaaa gccgaagctg cacaccgcat cctggaaggg ctggggcccc
     1081 aggtggagct gcctctgtac aaccagccgt ccgacacacg ccagtaccat gagaacatca
     1141 aaataaacca ggcgatgcgg aagaagctga tcttgtactt caagcggagg aaccacgcac
     1201 gcaagcagtg ggagcagcgc ttctgccagc gctatgacca gctcatggag gcatgggaga
     1261 agaaggtgga gcgcattgag aacaatccgc ggagaagggc caaggagagc aaggtgaggg
     1321 agtactacga gaaacagttc ccggagatcc gcaagcagcg ggagctgcag gagcgcatgc
     1381 agagcagggt gggccagcgt ggcagtgggc tctccatgtc ggcggcacgc agtgagcatg
     1441 aggtttctga gatcatcgat ggcttgtctg agcaggagaa cctggagaag cagatgcgcc
     1501 agctggctgt gatcccgccc atgttgtacg atgcggacca gcagaggatc aagttcatca
     1561 acatgaacgg actcatggac gaccccatga aggtgtacaa agaccgccag gttaccaaca
     1621 tgtggagtga gcaggagagg gacaccttcc gcgagaagtt catgcagcat cccaagaact
     1681 ttggcctgat cgcctcattc ctggagagaa agacagtagc cgagtgtgtc ctctattact
     1741 acctgaccaa gaagaatgag aactacaaga gcttggtgag gcgcagctat cggcgccgtg
     1801 gcaagagtca gcagcaacag cagcagcaac agcagcagca gcagcagcag atggcacgga
     1861 gcagccagga ggagaaggag gagaaggaga aggagaagga agccgacaag gaggaggaga
     1921 agcaggatgc ggagaacgag aaggaagaac tcagcaagga gaagacagac gacacttctg
     1981 gagaggacaa cgatgagaaa gaggctgtgg cctccaaagg ccgcaaaact gccaacagcc
     2041 aaggccgccg caaaggccgg atcacacgct ccatggccaa cgaggccaac catgaggaga
     2101 cggccacccc gcagcaaagt tcagagctag cttccatgga gatgaacgag agctctcgct
     2161 ggactgagga agagatggag acagcaaaga aaggcctcct ggaacatggg aggaactggt
     2221 cagccatcgc ccgcatggtg ggctccaaga ctgtgtccca gtgtaagaac ttttacttca
     2281 actacaagaa gaggcagaac ctggacgaaa tccttcagca gcacaagcta aagatggaga
     2341 aggagaggaa tgcccggagg aagaaaaaga agaccccggc tgcggcaagt gaggagacag
     2401 ccttcccacc tgccgctgag gacgaagaga tggaggcgtc tggtgcaagt gccaatgagg
     2461 aagaactggc ggaggaggca gaagcctcac aggcctccgg gaatgaggtt cccagagttg
     2521 gagagtgcag tggcccagct gctgtcaaca acagctctga tactgagagt gtcccatccc
     2581 cgcgcacgga agccaccaag gacgctggtc ctaagcctgc tagcactgaa gcattgcccg
     2641 ctgccaccca gccacctgtt cctcctccag aagaacccgc aacagtccct gatgagccct
     2701 gcccagcccc tgatgccagt ggcccaccat ccccagtggc ttccccacca cctgccgcac
     2761 ccccggctgc tgttgacaag gatgaacaag accaggctgc tactgttccc cagaccgagg
     2821 atgccaagga gcagaagtct gaggccgagg agctggtgat tgatgtggga aagacagagg
     2881 aacccgaggc ccctgaggag ccaccagaga gtgtaaagag tgatcacaag gaggagactg
     2941 aggaggagcc tgaagacaaa gccaagggcc cagaggccat tgagactgtg tccgaggcgc
     3001 cacttaaggt ggaggaggct ggaagcaagg cagctgtgac caagggttcc agctcgggtg
     3061 ccacccagga cagtgactcc agtgccacct gcagtgccga tgaggtggat gagcccgagg
     3121 gaggtgacaa gggcaggctg ctgtcaccaa ggcccagcct cctcacccca gccggagatc
     3181 cccgggccag tacctcgccc cagaagccgc tggacctgaa gcagctgaag cagcgagcag
     3241 cagccatccc ccctattgtc accaaggtcc atgaaccccc ccgggaggac acagtacccc
     3301 caaagccagc tccccctgtg cctccaccca cgcagcacct acagccagag ggtgacgtgt
     3361 ctcagcagtc gggaggaagt ccacgtggca agtgccgcag cccggtgcct cccgccgaga
     3421 aagaggcaga gaaagcttca ttctttcccg ccttcccagc tgagggcccg aagcttccta
     3481 ctgagccccc acgctggaca tcgggtctgc cttttcccat tcctcctcgg gaagtgatca
     3541 agacttcccc acacgctgca gacccctctg ccttctccta cacaccccct ggtcaccctc
     3601 tgcctctggg cctccacgat agtgcccggc cggtcctgcc acgtcccccc atctctaacc
     3661 ccccacccct catctcctct gccaagcacc ctggtgtact tgagaggcag ctgggtacca
     3721 tctcccagca gggaatgtca gtgcagcttc gcgtgcccca ctcagagcat gccaaggccc
     3781 ccatgggccc tctcaccatg ggactgcctc tcgctgtgga ccctaagaag ctggggacag
     3841 cactgggctc cactgccagt ggaagcatca ccaagggcct ccccagtacc cggactgcag
     3901 atggccccag ctaccgaggc tctatcaccc acggcacgcc agcagacgtc ctctacaagg
     3961 gtaccatcag caggatcgtt ggtgaggaca gcccaagtcg ccttgatcgg gcacgagagg
     4021 ataccctgcc caagggccat gtcatctatg agggcaagaa aggccatgtc ctatcctatg
     4081 aaggtggtat gtcggtgtca cagtgctcca aggaggatgg gaggagcagc tcaggcccac
     4141 cccacgagac tgccgcccct aaacgcacct atgacatgat ggagggccgt gtgggcagga
     4201 ccatcacctc agccagcatc gagggactca tgggccgtgc catccctgag cagcacagcc
     4261 cccacctcaa ggagcaacat cacatccgag gctccatcac gcaaggcatc ccgaggtcat
     4321 atgtggaggc ccaggaggac tacttacgta gggaggccaa gctcttgaag cgagaaggca
     4381 cgccaccgcc cccaccgcca cctcgggacc tgactgagac ctacaagacc cggcccctcg
     4441 accctctggg tcccctgaag ctgaagccaa ctcatgaggg tgtggtagcg actgtgaagg
     4501 aggcgggccg ctctatccat gagatcccac gagaggagct gcgccgcacg cccgagctgc
     4561 ccctggcacc acggcctctg aaggagggtt ccatcaccca ggggacccca ctcaagtacg
     4621 actccggggt gccctccagt ggctccaaga aacacgacgt acgctccatc atcggcagcc
     4681 ccggccggcc ttttcctgcc ctgcacccac tggacataat ggctgatgcc cgggcactag
     4741 agcgcgcctg ctatgaagag agtctgaaga gccggtcagg gaccagcagt ggtgcagggg
     4801 gctccatcac acgcggggcc ccagttgtcg tgcctgagct aggcaagccc cggcaaagcc
     4861 cactggccta cgaggaccac ggggcaccct tcaccagcca cctgccccga ggctcacctg
     4921 tgactaccag ggagcccacg ccacgccttc aggaaggcag cctcctctcc agcaaggcgt
     4981 cccaggaccg gaagctgacc tcgacacccc gggagattgc caagtcccca catagcactg
     5041 tgcccgagca ccacccccac cccatctccc cctacgagca cctgctccgg ggtgtgactg
     5101 gtgtggacct gtaccgtggc cacatcccat tggcctttga ccccacctcc ataccccgag
     5161 ggatccctct ggaagcagca gccgcagcct actacctgcc ccggcacttg gcccccagcc
     5221 ccacctaccc acacctgtac ccgccttacc tcatccgcgg ctaccctgac accgcggccc
     5281 tggagaaccg ccagaccatc atcaatgact acatcacctc gcagcagatg caccacaacg
     5341 cagcctctgc catggcccag cgcgccgata tgctgagggg tctgtcaccg agagagtcct
     5401 cgctggccct caattatgcc gctggcccgc gtggcattat cgacctgtcc caagtgccac
     5461 acctgcccgt gctggtgccg ccaactccag gcacccctgc caccgccatc gaccgccttg
     5521 cctacctccc cactgcgccc ccacccttca gcagccgtca cagcagttca ccactgtccc
     5581 caggaggccc cactcaccta gctaaaccaa ctgccacgtc atcatcggag cgggaacggg
     5641 aacgagagcg agaacgagac aagtccatcc tcacgtccac cactacagtg gagcatgcac
     5701 ccatctggag acctggtacg gagcagagca gcggggctgg gggcagcagc cgccccgcct
     5761 cccacaccca ccagcactcg cccatctccc cccggaccca ggacgccttg cagcagaggc
     5821 ccagtgtgct gcacaacacg agcatgaagg gcgtggtcac ctccgtggaa cccggcacgc
     5881 ccacggtcct gaggtgggcc aggtccacct ccacctcttc acctgtccgc ccagctgcca
     5941 cattcccacc tgccacccac tgcccacttg gtggcaccct cgaaggggtc taccctaccc
     6001 tcatggagcc agtcctgtta cccaaggaga cctctcgggt tacccggcct gagcggcccc
     6061 gtgtggacgc tggccatgcc ttcctcacca agcccccagc ccgggagcct gcctcctcac
     6121 ccagcaagag ctccgaaccc cgatccctag caccccccag ctccagccac acagccatcg
     6181 cccgcacccc agcaaagagc cttgcacccc accatgccag tccggacctg ccggcgccca
     6241 cctcggcctc agatctgcac cgagaaaaga ctcaaagtaa acccttttcc atccaggaat
     6301 tggaactccg ttctctgggt taccacagtg gagctggcta cagccctgat ggggtagagc
     6361 ccatcagccc cgtgagctcg cccagcctga cccacgacaa ggggctctcc aagcctctgg
     6421 aagagctaga gaagagccac ttggaggggg agctgcggca caagcagcca ggccccatga
     6481 agctcagtgg ggaggctgcc cacctcccac atctgcggcc actgccggag agccagccct
     6541 catccagccc actcctccag actgccccag gcatcaaagg tcaccagagg gtggtcacct
     6601 tggctcagca catcagtgag gtcattacac aggactacac acgccaccac ccacagcagc
     6661 tcagtggccc ccttcccgcc cctctctact ccttccctgg agccagctgc cctgtcctgg
     6721 atctccgccg tccacccagt gacctctacc tcccaccccc ggaccatggc accccagccc
     6781 ggggatcccc ccacagtgaa gggggcaaaa ggtctccaga acccagcaaa acagtcctga
     6841 gtagcagcga ggatgctatt gaacctgtgt ccccaccgga gggcatgact gagccaggac
     6901 atgcacggag cactgcgtac ccactgctgt accgggacgg ggagcagggg gagcccagga
     6961 tgggttctaa gtctccaggc aacaccagcc agccgccagc cttcttcagt aagctgaccg
     7021 agagcaactc cgccatggtg aagtcgaaga agcaggagat caacaagaaa ctcaacaccc
     7081 ataaccggaa tgagcctgaa tacaatatcg gccagcctgg gacggaaatc ttcaacatgc
     7141 ccgccatcac tggagcaggc cttatgacct gtagaagcca ggcggtgcaa gaacacgcca
     7201 gcaccaacat ggggctagag gccattatta gaaaggcact catgggtaaa tatgatcagt
     7261 gggaagagcc cccgccgctc ggcgccaatg cttttaaccc tctgaatgcc agtgccagtc
     7321 tgcccgctgc cgctatgccc ataaccactg ctgacggacg gagtgaccac ccactcacct
     7381 cgccaggtgg tggtgggaaa gccaaggttt ctggcagacc cagcagccga aaagccaagt
     7441 cgccagcgcc aggcctggca cccggagacc gaccaccttc tgtctcctca gtacactcgg
     7501 agggcgactg caatcgccga acaccactca ccaaccgtgt gtgggaggac cggccctcat
     7561 ctgcagggtc cacgccattc ccctacaacc ctttgattat gaggctacag gcaggtgtca
     7621 tggcctcccc acccccacct ggccttgccg caggcagcgg gcccctagct ggtccccacc
     7681 atgcctggga tgaggagccc aagccactgc tgtgttcaca gtacgagaca ctctcggaca
     7741 gcgagtgacc acagattggg ggggagcggt gccaggtccc tgcacgaggc agaagcagcc
     7801 cagcatggag cagacagctg ccaactcccc cgactgagga aggagcccct gaatctgcct
     7861 gcgcgtccat ccgtccgtcc gtctactcat ctgtccatcc agagctggca tcctgcctgt
     7921 ctaaagcctt aactaagact cccgccccgg gctggccctg cgcagtgacc ttacactcag
     7981 gggatgttta cctggtgctc gagaggggag tggacaggag gggaggccag cgggccggga
     8041 gaggggtaca gtgatcgtgt gtcagttgca cgcgtgcatc tggggcagcg gggacccaac
     8101 acaggatgac caggcacctc catgccactg cctcgcccct taccgcattt ggaaccaaag
     8161 tctaagctga gctcgcggcc ctgcccctcc ctctgccccc agcccgctcg cgctctggac
     8221 agacagacgt tcccagctta tcctgcccca tcgctgtcat cgcagtcccc aaaggccacc
     8281 cagcccacaa gactgggagc ccatcagacc aggtgggtgc acaaagggcc gggtatggcc
     8341 tggggcacgg atgtttgcag gaaccggacc gttcattccc ggcctgtcgc tatggcgatg
     8401 gcggggaagg caggtgtaaa tggtgttggc ttacagggta tatttttgat accttcaatg
     8461 agttaattca gtcgcttcac acaaggaagg actcacccgt gttactgccg ctgtgctttg
     8521 gtctctgctt cctgtcccag aggcatgtgc cggccaaggc ggtggcccca ccatacgcag
     8581 gactgggggg caggggctcc ggcacacggc actgtgccct ccccctccct tccttgggca
     8641 gaatggactt gatgcgtatt ctgtggccgc tctctgcacg gcggcattct gtcatttaca
     8701 catgttgttc caattaaaag gcaaattata ctccagttac aaa
//
LOCUS       NM_001014035            5474 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 4, mRNA.
ACCESSION   NM_001014035 XM_226648
VERSION     NM_001014035.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5474)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5474)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5474)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5474)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5474)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5474)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5474)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5474)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5474)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5474)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced NM_001014035.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1300.1,
                                           SRR21887620.520416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345329,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-170             JAXUCZ010000001.1  130365401-130365453 c
            171-364             JAXUCZ010000001.1  130337632-130337825 c
            365-568             JAXUCZ010000001.1  130317243-130317446 c
            569-706             JAXUCZ010000001.1  130292969-130293106 c
            707-926             JAXUCZ010000001.1  130290825-130291044 c
            927-986             JAXUCZ010000001.1  130289823-130289882 c
            987-1174            JAXUCZ010000001.1  130277028-130277215 c
            1175-1301           JAXUCZ010000001.1  130267560-130267686 c
            1302-1428           JAXUCZ010000001.1  130263566-130263692 c
            1429-5474           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5474
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..170
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..364
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    299..301
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             311..1798
                     /gene="Mef2a"
                     /note="isoform 3 is encoded by transcript variant 4;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 3"
                     /protein_id="NP_001014057.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPD
                     TSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPG
                     SSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPN
                     GAGNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVV
                     IPPSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSL
                     TSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNI
                     NIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSS
                     SSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="Phosphoserine, by CK2. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     phosphorylation site"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    599..772
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    599..772
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    602..604
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    <695..>1426
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <695..>1426
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    833..985
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    947..952
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     misc_feature    1013..1015
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1034..1123
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1055..1057
                     /gene="Mef2a"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1073..1075
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1106..1159
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Required for interaction with MAPKs.
                     /evidence=ECO:0000250"
     misc_feature    1220..1222
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1241..1243
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1349..1351
                     /gene="Mef2a"
                     /note="Phosphoserine, by MAPK7.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1454..1795
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1493..1495
                     /gene="Mef2a"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1508..1510
                     /gene="Mef2a"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1529..1531
                     /gene="Mef2a"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q60929; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1631..1633
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1670..1675
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     exon            365..568
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            569..706
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            707..926
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            927..986
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1174
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1301
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1428
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..5474
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcggaa
      121 ttgcatcttg tggaaaagga acaaagaaga actttctgca aggataaaat atttttaaga
      181 caatttcagc ggcagccttg gactggaagg ttaaataata ggaactgtgt acgatgcatt
      241 aggatattga agaaaattag cttctgaatt aattatttgg aatataagga agaaaaggtg
      301 acttttgaaa atggggcgaa agaaaataca aattacacgc ataatggatg agaggaaccg
      361 acaggtgact tttacaaagc gaaagttcgg attgatgaag aaagcctatg aactcagtgt
      421 gctctgtgac tgtgagatag cactcatcat cttcaacagc tctaacaagt tgtttcagta
      481 cgccagcact gacatggaca aagtccttct caagtacacc gagtacaacg agcctcatga
      541 aagcaggacg aactcggata ttgtggaggc tctgaacaag aaggaacaca gaggctgcga
      601 cagcccagac cctgatactt catatgtgct aactccacat acagaagaaa aatataaaaa
      661 aattaatgag gaatttgata atatgatgcg gaatcataaa atcgcacctg gcttgccgcc
      721 tcagaacttc tcaatgtctg tcacagtccc tgtgaccagc cctaatgctt tgtcgtacac
      781 taacccaggg agttcactcg tgtcaccgtc tttggcagcc agctcaacat tagcagagtc
      841 cagcatgctg tctccacccc cagccacgct acatagaaat gtgtctccag gagctccgca
      901 gagaccacca agcactggca gtgcaggtgg gatgttgagc actacagacc tcacggtacc
      961 aaatggagct ggaaatagtc ctgtggggaa tggatttgta aactcaaggg cctctccaaa
     1021 tttgattgga aatactggtg cgaatagtgt aggcaaagtc atgcctacaa agtccccccc
     1081 gccaccaggt gggggcagtg ttggaatgaa cagtcggaaa ccagatctac gggttgtcat
     1141 tcccccttca agcaagggca tgatgccccc acttaatgcc caaaggataa gtagttctca
     1201 agccacacaa cctcttgcca cgcccgtggt gtctgtgaca actccaagct tgcctccgca
     1261 gggactagtg tactcggcca tgccgacagc ctacaacact gattactcat tgaccagcgc
     1321 tgacctgtcc gccctgcaag gctttacttc ccctggaatg ctgtctctgg ggcaggcttc
     1381 agcctggcag cagcaccatc taggacaagc ggccctcagc tctctagtgg ctggagggca
     1441 gttatctcag ggttcaaatt tgtccattaa caccaaccag aacatcaaca ttaagtcaga
     1501 gccaatttca cctccccgtg atagaatgac cccatcaggc ttccagcagc agcagcagca
     1561 gcagccacag cagcaaccac cgccacaacc tccacagccc cagccccaac cccggcagga
     1621 aatggggcgc tcccctgtgg acagtctgag cagctctagc agctcctacg atggcagtga
     1681 ccgggaggat ccacggggcg acttccattc tccaattgtg cttggccgac ctccaaatgc
     1741 tgaggacaga gaaagcccct ctgtaaaacg catgaggatg gacacatggg tgacctaagg
     1801 cttcctggtt catgtctgtt ctttgtgtta ctgcagtgaa ctgccctaca tatcttaaat
     1861 tggtgaataa ggacatgagt tcaatatatt tatatgtaca tgcatacata tatatccctt
     1921 tacatatata tgtatgtcgg tgtgagtgtg tgtatgtgtg ggtgtgtgtt gcatacacag
     1981 aatcaggcac ttactgcgac tccttgtagg tatgcagatg tgtgcacacg gcacacagag
     2041 caccttgtag agacagacca gcctggcact tccttggact acttgtctcc taagataaag
     2101 tttttgcaga gaaacgtgta cccatatata attcttccac attagcctgc agaaacctag
     2161 gggcccctat ttgttttatt tacctgtgcg gtgactgtag ttacttcaaa aaaaaaaaaa
     2221 attgctttgt agaacagagc agtagaaaag caggaaccaa gaaagcaata ctgtacataa
     2281 agtcatttat attaataacc caacctggca tgggtctatt gcagaggggt gcatgggcaa
     2341 gggctgtcta tattaaacag acacagtaaa caaagagccc cacacataac tgttttgcac
     2401 gtgcaaaaaa atgtattggg tcaaagaagt gatttttagc tattaaaaag agagaataga
     2461 aaacacgcat gaaatattca gaaatactag cctagaaata tagagcatta acaaaataaa
     2521 attaatatat taagttataa ttggaatatg tcagaagttt cttttacatt catatcttta
     2581 aaaattaaag aaactgattt taggtcatgt atattttata tgaaagaaaa cacccttaat
     2641 gaattgatga ctatatataa aattatatcc actacttttg aacacattct gctgaattat
     2701 ttatataagc caaagctgta tgttgtaact ttttttttta aagaatagct ttatcttgtt
     2761 ttaacttttt agttttattt taagagggaa gaaaaaaaca aaaatatctt gcaagcagaa
     2821 ccttggaaaa aaaaaagcca tgaacattat tattctatat gtaaattaaa agtcgagcca
     2881 aactctttgt gtatatagca tcttaaatat attaccacct ttgatgtaag tacctatgta
     2941 ttgtatggtc accagattaa aaagtatatt tttgtggatt gccaccaatt tggggggaaa
     3001 ggcgaagtcc ttaagtagag tattcactgt ttaatattta ctattttgtt aaatatactg
     3061 tactttggat tttaattatt agcccagttt ttcagaggat tgtgtaaagg ggtttcccct
     3121 cactggtggt gaatgtgtga tgttctgttg taatctttgt gctgtatggg gtgagcatca
     3181 ttatatattt tatatgtgta cataaatagc aaagtggcaa aaaaattggt gttaagttca
     3241 tcctgcataa atataaaatg tgttgtaaca gattttataa ggcattattt aaaacttgcc
     3301 ttttgtgagg gaaaaaaaaa aacagtagaa agatgaccta atttaactaa tattagagaa
     3361 aatggctgag tagtagatga gcacaaaggt tttataagtg gtaaataatt aggaaaatat
     3421 ttgtagggga agggatcttt tctccttgac tctaaagata gaatgatgca gctggttaca
     3481 aaatccagga gggctttagc gtcccgtgcg tgggaaggca cgggcgtgca gggagcagct
     3541 ctcctatggt gcagatcccc gacacaattc ttgctgtcct gacggaaact ggtgccaccc
     3601 tcagcttgga ttttgaacaa ggccttactc ttacagggag acagctcgtt ggtgatggca
     3661 agttcatccg tttactgggc ttgtgccatg aacaaaattc aaagtcctgt atatctttta
     3721 tcctagattt ttaaatactc cttttcctga aaaaacttaa agagtttaaa aatggctgct
     3781 attttatact gaacaatgtt gagcagctac ctgcagtttt tacttacatt ttgcttttcc
     3841 cctcgattcc ctaaattatg ctccttttga tgtctcctca tctgctgtcc cgacagctca
     3901 tcagccaggt ttcctgcctg gccgcacaca ggtattcggt ccatgcaccg tggtgagcac
     3961 aggctgtgca ctggagagcc tcactgacag tctgggtagc acatgttagt ggaagccaag
     4021 gaagtgggga cggtgtctca tctcctctgt ggtctcagca cttggctctt cctcagagaa
     4081 ggttaggttt tcttcctcaa gtgtactgag ttgacttaca ggcacgttcc tcataaggtc
     4141 acagtctccc aacactgact ttccaagata ccccttacca ctttgtaaac catttatagc
     4201 tttgaaagta ttaagtgacc ctttcattat tatttatgca tgttcatgaa cttctgctgt
     4261 atattgggat aggagttaac acattcacat ttactgtcta ttttcttgtg tgccttatga
     4321 gatggcttct ctgactgtat ctcaatagtc tttctatgca ggtttataat cagtacaact
     4381 actgttttct aaaggaatat tacacacggc tcggagtttg tacttaaatt acactgacca
     4441 agtcacaatg tattccgttt tcaggaactg aatatctgac tgttaatctt ttcccatatg
     4501 cccagtgtga tctggagcat atgggtctga catccttcac ccagatgctc atgtgtgaac
     4561 acatccacat ccacagctct cagtggaagc cagcctagag tagggaggac actgacggtg
     4621 ttgctttaaa ctgacttttc ttaccctttg agactcatgt gttttgtata agacaccatc
     4681 acaagaaagt tttctccctt cagataacat attttattat taaaaagaaa aacaaaaaaa
     4741 gcttttaagt tgcactggac gtgggccgtt ccttcggaac tctttggatc tacactgaga
     4801 gtgagtgtcg ccgctctgtg aacacaggtg gtcccagtca aaactccatc ctttgagccc
     4861 taattacatc cattgtgtta caaaactaaa tcaggggttt gttctaaaag aacaatacat
     4921 gtctcaccat ttcctttcaa ctgtaaagac gactgataat gtattaacat aatttctgta
     4981 ttaaccatca tgcgcacaag aaatacatag taaatacgga acctgaaaac tcctgcatcg
     5041 gatcataaaa gctagatgat tagaatgtga aaagaacttt acagatgtaa aacttttatt
     5101 tctctgtaga aactttcttc actttgctgt gcaagaagac actgctttgc tatatttaaa
     5161 atggcttttt taaaaagaga tttatgtatt tggtaaatgt ttgtagtcaa cagttcacac
     5221 aaagaagctg tacacggttt gatcatgtaa aaccgtttgg cggcacaagc tggactttgt
     5281 tgccatcctt gagatgaacc ttttaagaaa aataagttaa tctcaatttt tccctgaatg
     5341 tgttgttttt tcttcattat acaataaata ttatagtgaa gtttttatca aatggttaag
     5401 acaatgctag aggttgttgt aagctatttg tctcctgcac tcactccagt aaagatggcc
     5461 tggctttgac cata
//
LOCUS       NM_001437558            4201 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 10, mRNA.
ACCESSION   NM_001437558 XM_063287221
VERSION     NM_001437558.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287221.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1356056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-3360            JAXUCZ010000001.1  254857400-254860256
            3361-3414           JAXUCZ010000001.1  254860529-254860582
            3415-3472           JAXUCZ010000001.1  254861917-254861974
            3473-3610           JAXUCZ010000001.1  254865878-254866015
            3611-3677           JAXUCZ010000001.1  254866108-254866174
            3678-3799           JAXUCZ010000001.1  254866293-254866414
            3800-3951           JAXUCZ010000001.1  254866843-254866994
            3952-4201           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4201
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4055
                     /gene="Pprc1"
                     /note="isoform 10 is encoded by transcript variant 10;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 10"
                     /protein_id="NP_001424487.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSVE
                     MSLADSPWDFSPPPFLETSSPKLPSWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSG
                     QMLDGELDNSVNTLDFPMHLACPEEEDKSGAANVAVSAPGDESISSLSELVRAMHPYC
                     LPNLTQLASLDAELQEQADDLTLPEGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQS
                     VLLDGSVGTDPALQLLMPAMEPGTEDGVPKVAPCPDQELPLSSACLLEPRDIMESLAP
                     KEPRNLPANASEGSQRVPRKGRKKKKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQ
                     AGNLQKQPQEELQRETAAPQSRGKPRAWARAWAAALEKTGSEDPEDQNAGQDSPAEED
                     VLELRPKLVETSQADPTLSLNDSARADSIPVNSVEGDSTAVDTAVPVDQASSCTELVG
                     SLSGGPILSSPVLDDRTGVEPAVAIPTSNHLSPADAILANPGTADPAPNGLAPGDPVL
                     VKCRPTDPRRAAAAATAAQGPRPSLEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEA
                     RPRPLSLSEYRQRRRQRQIEAEDRNSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKT
                     APQRSPIAVPETCSVSVGSNPVSPTPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTL
                     QSMAPAGPTPSTVPTPLPFPPSLPPLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPP
                     DPYTQYAPVPPWPCYPSVSPSGYSCLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAP
                     VSPYSSSSAYGSLGWGPGLQQPPFWSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPE
                     DTLPVPVTPSLSSRPASPIAPPAEPTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTL
                     SAEGVAIGESESERLKPETQENRPREKPISTATKAVLLPKQSTVAKLPAVHPARLRRL
                     SFLPTPRAQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPLPAPADSVAVGN
                     SGSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYSSYRSNDHY
                     QRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGF
                     VTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVK
                     SKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1059..2456
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1059..2456
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1815..3272
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1815..3272
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3681..3953
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    3681..3953
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..3360
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3414
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3472
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3610
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3677
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3799
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3951
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4201
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctgttgaga tgtcccttgc agattctccg tgggacttct
      541 ctccacctcc tttcttggaa acttcttccc ctaagctgcc tagctggaga tcctcaagac
      601 caagacctcg atggagtcag tctcctcctc cccagcagcg cagtgatgga gaggaggagg
      661 aagaggttgc cggcttcagt ggtcagatgc ttgatggcga acttgacaac tcggtgaata
      721 ccttggattt ccccatgcac ctggcatgcc ctgaggaaga agacaagtca ggggcagcaa
      781 atgtggcagt gtcagcacct ggtgacgaga gcatctcctc cttgagtgag ctggtacggg
      841 ccatgcaccc ctactgctta cccaacctca cccagttggc atcacttgac gctgagcttc
      901 aggagcaggc tgatgatctg acactgcctg agggttgtgt ggtgctggag attgtgggcc
      961 aggcagccac agctggtgat gacctggaga tcccagtggt cgtgcggcag attccttcag
     1021 gatcccagtc tgtgctccta gatgggtctg tagggactga tcctgccttg cagctactca
     1081 tgcccgccat ggagcctgga acagaagatg gtgtgcctaa agtcgctcct tgccctgatc
     1141 aagaattacc actgagctct gcctgcttat tggagcccag ggacatcatg gagtcattgg
     1201 cccccaagga gcctcggaac ctacctgcca atgcaagtga gggttctcag agagttccca
     1261 gaaagggtag gaagaagaag aagaaggagc agccaacagc ctgtttggaa ggctgtacca
     1321 ggaggctgag gtcatcttct cgtggacagt ctactgtggc tacagaggtg aactctcagg
     1381 caggcaactt acagaaacag cctcaggaag agcttcagag agagactgcg gcccctcaga
     1441 gcagagggaa gccacgggct tgggctcggg cctgggcagc tgccttggag aaaactgggt
     1501 ctgaagaccc agaggaccag aatgcaggac aggatagtcc tgctgaggaa gatgttctag
     1561 aactccgtcc taagctggtg gagactagcc aagccgaccc cacgctctca ctaaacgact
     1621 ctgctcgagc tgactccatc ccagttaact ctgttgaagg tgactccact gcagtggaca
     1681 ctgctgtacc tgttgaccag gcttcatctt gtacagagct ggttggttct ctctcaggag
     1741 gcccaattct gagtagccca gtcctagatg acaggacagg agttgaacct gcagtggcta
     1801 ttcccacttc aaatcacttg tctccagctg atgctatcct agctaaccca gggacagctg
     1861 accctgctcc aaatggcctg gctccaggag atcctgtgct agttaagtgc agaccaactg
     1921 atcctagacg tgcagctgct gctgccactg ctgctcaggg gcctcgtcct tccctagagc
     1981 cctcagacca tcctaaggtc atcacccctg aagtcaagga tgctggaggt cctctgaagg
     2041 tggaaggtag taccagtgct acaacccagg aagccagacc tcggcccctc agcctatctg
     2101 agtaccgtca acgacggcgg caacggcaaa tagaagcaga agacaggaat tctcagcccc
     2161 cagctggaaa gtggccaagt ctcccagaga cgcccaaagg gctggcagat atcccttgtc
     2221 ttgttccatc agccccaacc aagaagacag ccccacagag aagccctata gctgtaccag
     2281 agacttgttc tgtatctgtg ggttctaacc ctgtttcccc tactcctgag ccatctgcaa
     2341 gcaaacttat ggtttcaact cactctgaac aggtgtcatc tcatgagatg ccacttccag
     2401 ttagacttcc ccctcctaca ttgcagtcta tggctcctgc tgggcccacc ccttctacag
     2461 tgcccacgcc attgcctttc cctccgagct tacctcctct gcttcctctt cctgcaagtg
     2521 gtcctggtgt ccccagcctg cccccacctc ctttgcaacc tcctggactt ccagtatcaa
     2581 tgagacaaat gccacctgac ccctatactc agtatgcccc tgtgccgccc tggccttgtt
     2641 acccctctgt atctccttct ggctattctt gtctgccccc accaccagcg atgcccatag
     2701 tgtcgggtac ccctggtacc tatgctgtac ccccaacttg caatgtgcct tgggtacccc
     2761 ctcctgcacc agtctcacct tatagctcca gctctgccta tgggtccctt gggtggggcc
     2821 cagggttgca acagcctccc ttttggtcta ctgtttctcc acctccattg tcttcagcct
     2881 ctactggtag agctgttccc ccacccagtg tggaacccag taacagttca gctggtcctc
     2941 cggaagatac acttcctgtg ccagtgaccc cttccctgag ctctcggcca gccagcccca
     3001 tagctccacc agcagaacct acgaagctgg aggctcagcc agtgcctgtc tctccccaac
     3061 cgaaacacaa agtgtcccct gtggtacaga gtccccagat caaggttcta ccaactctgt
     3121 ctgctgaggg cgtggctatt ggggaatctg aatcagagag gctaaagccg gagacccagg
     3181 agaacagacc aagggagaag cctatctcta cggctacgaa ggctgttctg ttaccaaagc
     3241 agagcactgt cgcaaaactg cctgccgtcc atccagcccg gctaaggagg ctgtccttcc
     3301 tgcccacccc acgtgctcag ggttctgagg atgtggtgca ggcattcatc agtgagattg
     3361 ggattgaagc atcagacctg tccagtctgt tggagcagtt tgagaaatca gaagccaaaa
     3421 aggagtgtcc tctcccggct cctgctgaca gcgtggctgt aggaaactca gggtccagct
     3481 gcagttcctc tggacggtcc agaagatgtt cctcctcttc ctcttcttcc tcctcctcat
     3541 cttcatcatc cagttccaga agccggtctc cctctgtgtc cccttgcagg agaagtgacc
     3601 ggaggcggcg gtacagctct taccgttcaa atgaccatta ccaaaggcag agagtactgc
     3661 agaaggagcg tgcaatagaa gagagaaggg tggtcttcat tgggaaaata cctggccgca
     3721 tgactcggtc ggagctgaag cagaggttct ctgtttttgg agagattgag gagtgtacca
     3781 ttcattttcg tgtccaaggt gacaactatg gtttcgtcac ttaccggtat gctgaagagg
     3841 catttgcagc cattgagagt ggccacaagt tgcggcaggc agacgagcag ccctttgatc
     3901 tctgctttgg gggccgaagg cagttctgca agaggagtta ctctgatctt gactccaatc
     3961 gggaagactt tgatcctgct cctgtcaaga gcaaattcga ttctcttgac tttgatactt
     4021 tgttgaaaca ggcccagaag aacctaagga ggtaaccctg ggctttcctc ccccatccat
     4081 tttctctgga ggtgtccaac ctctcaaccc cctcccctac tctaggggag agagctgcta
     4141 gtgtggaaag acttttataa ggaaatgaaa aaaagttaaa taaaaatatg ttaaatcggg
     4201 a
//
LOCUS       NM_001437561            4250 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 13, mRNA.
ACCESSION   NM_001437561
VERSION     NM_001437561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4250)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2351875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000001.1  254851842-254851979
            139-312             JAXUCZ010000001.1  254856186-254856359
            313-459             JAXUCZ010000001.1  254856944-254857090
            460-552             JAXUCZ010000001.1  254857203-254857295
            553-3409            JAXUCZ010000001.1  254857400-254860256
            3410-3463           JAXUCZ010000001.1  254860529-254860582
            3464-3521           JAXUCZ010000001.1  254861917-254861974
            3522-3659           JAXUCZ010000001.1  254865878-254866015
            3660-3726           JAXUCZ010000001.1  254866108-254866174
            3727-3848           JAXUCZ010000001.1  254866293-254866414
            3849-4000           JAXUCZ010000001.1  254866843-254866994
            4001-4250           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..4250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4250
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..138
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..4104
                     /gene="Pprc1"
                     /note="isoform 13 is encoded by transcript variant 13;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 13"
                     /protein_id="NP_001424490.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MSTWLLSQAVGHLVSALEPHCRELGVSQPLPPSLACAGTSGLEV
                     HEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLISLIEDFGES
                     RLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLHKLLNLSRT
                     PPERDRIPAMDPLGPSAGSSRVEMSLADSPWDFSPPPFLETSSPKLPSWRSSRPRPRW
                     SQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPEEEDKSGAANVA
                     VSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLPEGCVVLEIVGQ
                     AATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGTEDGVPKVAPCP
                     DQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKKKKKEQPTACLE
                     GCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGKPRAWARAWAAA
                     LEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSARADSIPVNSVE
                     GDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVAIPTSNHLSPAD
                     AILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPSLEPSDHPKVIT
                     PEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDRNSQPPAGKWPS
                     LPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSPTPEPSASKLMV
                     STHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLPPLLPLPASGPG
                     VPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYSCLPPPPAMPIV
                     SGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPFWSTVSPPPLSS
                     ASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAEPTKLEAQPVPV
                     SPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRPREKPISTATKA
                     VLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGIEASDLSSLLEQ
                     FEKSEAKKECPLPAPADSVAVGNSGSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSP
                     SVSPCRRSDRRRRYSSYRSNDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQR
                     FSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRR
                     QFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1108..2505
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1108..2505
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1864..3321
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1864..3321
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3730..4002
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    3730..4002
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            139..312
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..459
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..552
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..3409
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3463
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3521
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3659
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3726
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3848
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4000
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4250
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaaggga tgtccacgtg gctcctgtcc caggctgtcg ggcatctagt atccgcgctg
       61 gagccgcact gccgggaact gggtgtgtcc cagccgctcc cgccatctct tgcctgtgct
      121 gggacctctg gtctggaggt ccatgaggaa ggagatgact ctagctttgt cagtctttct
      181 cgactgggcc catctctaag ggagaaagac ctggaaatgg aggaactgat actgcaggat
      241 gagacactac tagagaccat gcagaactac atggacgcct cccttatatc cctcattgag
      301 gattttggag agagcaggct atctttggag gaccagaatg agatgtcgct gctcacagct
      361 ctgacggaga tcttggacaa tgcagattct gagaacctgt ccccgtttga taccattcct
      421 gattcagagc tgctcgtgtc tcctcgggag agctcctctc tgcacaagct gctcaatctc
      481 tctcggacac ctccagaacg tgaccgcatc cccgcaatgg accctttggg gcccagcgca
      541 ggaagtagtc gggttgagat gtcccttgca gattctccgt gggacttctc tccacctcct
      601 ttcttggaaa cttcttcccc taagctgcct agctggagat cctcaagacc aagacctcga
      661 tggagtcagt ctcctcctcc ccagcagcgc agtgatggag aggaggagga agaggttgcc
      721 ggcttcagtg gtcagatgct tgatggcgaa cttgacaact cggtgaatac cttggatttc
      781 cccatgcacc tggcatgccc tgaggaagaa gacaagtcag gggcagcaaa tgtggcagtg
      841 tcagcacctg gtgacgagag catctcctcc ttgagtgagc tggtacgggc catgcacccc
      901 tactgcttac ccaacctcac ccagttggca tcacttgacg ctgagcttca ggagcaggct
      961 gatgatctga cactgcctga gggttgtgtg gtgctggaga ttgtgggcca ggcagccaca
     1021 gctggtgatg acctggagat cccagtggtc gtgcggcaga ttccttcagg atcccagtct
     1081 gtgctcctag atgggtctgt agggactgat cctgccttgc agctactcat gcccgccatg
     1141 gagcctggaa cagaagatgg tgtgcctaaa gtcgctcctt gccctgatca agaattacca
     1201 ctgagctctg cctgcttatt ggagcccagg gacatcatgg agtcattggc ccccaaggag
     1261 cctcggaacc tacctgccaa tgcaagtgag ggttctcaga gagttcccag aaagggtagg
     1321 aagaagaaga agaaggagca gccaacagcc tgtttggaag gctgtaccag gaggctgagg
     1381 tcatcttctc gtggacagtc tactgtggct acagaggtga actctcaggc aggcaactta
     1441 cagaaacagc ctcaggaaga gcttcagaga gagactgcgg cccctcagag cagagggaag
     1501 ccacgggctt gggctcgggc ctgggcagct gccttggaga aaactgggtc tgaagaccca
     1561 gaggaccaga atgcaggaca ggatagtcct gctgaggaag atgttctaga actccgtcct
     1621 aagctggtgg agactagcca agccgacccc acgctctcac taaacgactc tgctcgagct
     1681 gactccatcc cagttaactc tgttgaaggt gactccactg cagtggacac tgctgtacct
     1741 gttgaccagg cttcatcttg tacagagctg gttggttctc tctcaggagg cccaattctg
     1801 agtagcccag tcctagatga caggacagga gttgaacctg cagtggctat tcccacttca
     1861 aatcacttgt ctccagctga tgctatccta gctaacccag ggacagctga ccctgctcca
     1921 aatggcctgg ctccaggaga tcctgtgcta gttaagtgca gaccaactga tcctagacgt
     1981 gcagctgctg ctgccactgc tgctcagggg cctcgtcctt ccctagagcc ctcagaccat
     2041 cctaaggtca tcacccctga agtcaaggat gctggaggtc ctctgaaggt ggaaggtagt
     2101 accagtgcta caacccagga agccagacct cggcccctca gcctatctga gtaccgtcaa
     2161 cgacggcggc aacggcaaat agaagcagaa gacaggaatt ctcagccccc agctggaaag
     2221 tggccaagtc tcccagagac gcccaaaggg ctggcagata tcccttgtct tgttccatca
     2281 gccccaacca agaagacagc cccacagaga agccctatag ctgtaccaga gacttgttct
     2341 gtatctgtgg gttctaaccc tgtttcccct actcctgagc catctgcaag caaacttatg
     2401 gtttcaactc actctgaaca ggtgtcatct catgagatgc cacttccagt tagacttccc
     2461 cctcctacat tgcagtctat ggctcctgct gggcccaccc cttctacagt gcccacgcca
     2521 ttgcctttcc ctccgagctt acctcctctg cttcctcttc ctgcaagtgg tcctggtgtc
     2581 cccagcctgc ccccacctcc tttgcaacct cctggacttc cagtatcaat gagacaaatg
     2641 ccacctgacc cctatactca gtatgcccct gtgccgccct ggccttgtta cccctctgta
     2701 tctccttctg gctattcttg tctgccccca ccaccagcga tgcccatagt gtcgggtacc
     2761 cctggtacct atgctgtacc cccaacttgc aatgtgcctt gggtaccccc tcctgcacca
     2821 gtctcacctt atagctccag ctctgcctat gggtcccttg ggtggggccc agggttgcaa
     2881 cagcctccct tttggtctac tgtttctcca cctccattgt cttcagcctc tactggtaga
     2941 gctgttcccc cacccagtgt ggaacccagt aacagttcag ctggtcctcc ggaagataca
     3001 cttcctgtgc cagtgacccc ttccctgagc tctcggccag ccagccccat agctccacca
     3061 gcagaaccta cgaagctgga ggctcagcca gtgcctgtct ctccccaacc gaaacacaaa
     3121 gtgtcccctg tggtacagag tccccagatc aaggttctac caactctgtc tgctgagggc
     3181 gtggctattg gggaatctga atcagagagg ctaaagccgg agacccagga gaacagacca
     3241 agggagaagc ctatctctac ggctacgaag gctgttctgt taccaaagca gagcactgtc
     3301 gcaaaactgc ctgccgtcca tccagcccgg ctaaggaggc tgtccttcct gcccacccca
     3361 cgtgctcagg gttctgagga tgtggtgcag gcattcatca gtgagattgg gattgaagca
     3421 tcagacctgt ccagtctgtt ggagcagttt gagaaatcag aagccaaaaa ggagtgtcct
     3481 ctcccggctc ctgctgacag cgtggctgta ggaaactcag ggtccagctg cagttcctct
     3541 ggacggtcca gaagatgttc ctcctcttcc tcttcttcct cctcctcatc ttcatcatcc
     3601 agttccagaa gccggtctcc ctctgtgtcc ccttgcagga gaagtgaccg gaggcggcgg
     3661 tacagctctt accgttcaaa tgaccattac caaaggcaga gagtactgca gaaggagcgt
     3721 gcaatagaag agagaagggt ggtcttcatt gggaaaatac ctggccgcat gactcggtcg
     3781 gagctgaagc agaggttctc tgtttttgga gagattgagg agtgtaccat tcattttcgt
     3841 gtccaaggtg acaactatgg tttcgtcact taccggtatg ctgaagaggc atttgcagcc
     3901 attgagagtg gccacaagtt gcggcaggca gacgagcagc cctttgatct ctgctttggg
     3961 ggccgaaggc agttctgcaa gaggagttac tctgatcttg actccaatcg ggaagacttt
     4021 gatcctgctc ctgtcaagag caaattcgat tctcttgact ttgatacttt gttgaaacag
     4081 gcccagaaga acctaaggag gtaaccctgg gctttcctcc cccatccatt ttctctggag
     4141 gtgtccaacc tctcaacccc ctcccctact ctaggggaga gagctgctag tgtggaaaga
     4201 cttttataag gaaatgaaaa aaagttaaat aaaaatatgt taaatcggga
//
LOCUS       NM_001437552            5086 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 4, mRNA.
ACCESSION   NM_001437552 XM_063287192
VERSION     NM_001437552.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5086)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2257340.1,
                                           SRR26643296.4636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3645           JAXUCZ010000001.1  254862692-254862762
            3646-4363           JAXUCZ010000001.1  254863590-254864307
            4364-4501           JAXUCZ010000001.1  254865878-254866015
            4502-4562           JAXUCZ010000001.1  254866114-254866174
            4563-4684           JAXUCZ010000001.1  254866293-254866414
            4685-4836           JAXUCZ010000001.1  254866843-254866994
            4837-5086           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5086
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4940
                     /gene="Pprc1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 4"
                     /protein_id="NP_001424481.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSIDTPQEKKPLDRLHAPELANV
                     AGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGV
                     RGPSPVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAA
                     PPLPCTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQ
                     RSMRCYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSL
                     SPPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRSYR
                     SNDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQG
                     DNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFD
                     PAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4112
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4112
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4566..4838
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4566..4838
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3645
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..4363
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4501
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4562
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4684
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4836
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4837..5086
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact caggcagcat tgacactccc caggagaaga
     3601 aacccctaga ccggttacac gccccagaac tggccaacgt ggcagggctc accccgccag
     3661 ctacccctcc ccaccagtta tggaaacccc tggctgctgt ctcactgttg gccaaagcca
     3721 aatctcctaa atctactgcc caagagggaa ccctgaagcc tgaaggaatt acagaggcca
     3781 aacctccagc tgcagcctgc ctccaagaag gggtccgtgg ccctagtcca gtccatgtgg
     3841 gctctgggga ccatgactat tgtgtccgaa gcaggacacc cccaaaaaag atgcctgccc
     3901 tagtcatttc agagatgggc tctcgatgga atgtcaagcg ccatcaggac atcactatca
     3961 aacctgtctt gtcattgggc tcagctgccc ccccactccc atgcacaacc acttcccagg
     4021 aaccgcttga tcacaggact agcagtgagc aggcagatcc gtcagcgcct tgttttgccc
     4081 catccacctt gctgtctcct gaggcctcac cctgccggaa tgaaatgaac actaggactc
     4141 cctctgagcc cccagacaag cagcggtcaa tgcgctgtta ccgaaaagcc tgcagatcag
     4201 ccagcccccc aagtcggggc tggcaaggcc gccgtggccg tagcagccgt tctgtcagct
     4261 ctgggtccag ccggaccagt gaagcatcct catcctcatc ggtgtcttcc tcatcccggt
     4321 cccggtccag gtccctctcc cccccaaaca agaggtggcg aaggtccagc tgcagttcct
     4381 ctggacggtc cagaagatgt tcctcctctt cctcttcttc ctcctcctca tcttcatcat
     4441 ccagttccag aagccggtct ccctctgtgt ccccttgcag gagaagtgac cggaggcggc
     4501 gctcttaccg ttcaaatgac cattaccaaa ggcagagagt actgcagaag gagcgtgcaa
     4561 tagaagagag aagggtggtc ttcattggga aaatacctgg ccgcatgact cggtcggagc
     4621 tgaagcagag gttctctgtt tttggagaga ttgaggagtg taccattcat tttcgtgtcc
     4681 aaggtgacaa ctatggtttc gtcacttacc ggtatgctga agaggcattt gcagccattg
     4741 agagtggcca caagttgcgg caggcagacg agcagccctt tgatctctgc tttgggggcc
     4801 gaaggcagtt ctgcaagagg agttactctg atcttgactc caatcgggaa gactttgatc
     4861 ctgctcctgt caagagcaaa ttcgattctc ttgactttga tactttgttg aaacaggccc
     4921 agaagaacct aaggaggtaa ccctgggctt tcctccccca tccattttct ctggaggtgt
     4981 ccaacctctc aaccccctcc cctactctag gggagagagc tgctagtgtg gaaagacttt
     5041 tataaggaaa tgaaaaaaag ttaaataaaa atatgttaaa tcggga
//
LOCUS       NM_001437594            6047 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 5, mRNA.
ACCESSION   NM_001437594 XM_039081494
VERSION     NM_001437594.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6047)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6047)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 6047)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 6047)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 6047)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_039081494.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16093045,
                                           SAMN16093046 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000001.1  78409644-78409976   c
            334-635             JAXUCZ010000001.1  78402262-78402563   c
            636-793             JAXUCZ010000001.1  78401477-78401634   c
            794-834             JAXUCZ010000001.1  78398316-78398356   c
            835-893             JAXUCZ010000001.1  78398010-78398068   c
            894-1055            JAXUCZ010000001.1  78397058-78397219   c
            1056-1205           JAXUCZ010000001.1  78396669-78396818   c
            1206-1288           JAXUCZ010000001.1  78396228-78396310   c
            1289-1553           JAXUCZ010000001.1  78395632-78395896   c
            1554-1680           JAXUCZ010000001.1  78395199-78395325   c
            1681-1769           JAXUCZ010000001.1  78394918-78395006   c
            1770-1844           JAXUCZ010000001.1  78394740-78394814   c
            1845-1993           JAXUCZ010000001.1  78394489-78394637   c
            1994-2135           JAXUCZ010000001.1  78392927-78393068   c
            2136-2164           JAXUCZ010000001.1  78392786-78392814   c
            2165-2294           JAXUCZ010000001.1  78389932-78390061   c
            2295-2426           JAXUCZ010000001.1  78389705-78389836   c
            2427-2535           JAXUCZ010000001.1  78389331-78389439   c
            2536-2710           JAXUCZ010000001.1  78389017-78389191   c
            2711-2843           JAXUCZ010000001.1  78388632-78388764   c
            2844-6047           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..6047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..6047
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..333
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..635
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..793
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    699..701
                     /gene="Eps8l1"
                     /note="upstream in-frame stop codon"
     CDS             777..2930
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001424523.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     misc_feature    870..1262
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    870..1262
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    order(891..893,1128..1130,1188..1190)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(891..893,1128..1130,1188..1190)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(1086..1103,1149..1151,1218..1220,1230..1232)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(1086..1103,1149..1151,1218..1220,1230..1232)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    2220..2378
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    2220..2378
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    order(2220..2237,2241..2243,2250..2252,2259..2267,
                     2286..2303,2307..2333,2346..2357,2367..2378)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(2220..2237,2241..2243,2250..2252,2259..2267,
                     2286..2303,2307..2333,2346..2357,2367..2378)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(2241..2243,2253..2261,2310..2318,2322..2324,
                     2349..2354,2358..2369)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(2241..2243,2253..2261,2310..2318,2322..2324,
                     2349..2354,2358..2369)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    2643..2840
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     misc_feature    2643..2840
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     exon            794..834
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..893
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1055
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1205
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1288
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1553
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1680
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1769
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1844
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1993
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2135
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2164
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2294
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2426
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2535
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2710
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2843
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..6047
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcacct ttaatcccag cactcgggag gcaaaggcag tcagatctct gtgaattcga
       61 ggccagccaa acaaacaaca aacaaaaagt acagagacaa tatgaagaca cagaatgcat
      121 ctctcaaccc tcatcagaga aacttctatt tgtagcagag actcacagct gatcaaggca
      181 caaagaaaag gagactacag agagctcagc cctaacccgg acatctatgt catgctgcct
      241 cctcctaaga ctcagggatc attgttgaag agtggaaaga gtatgaggcc cagaggctgc
      301 agatgtctac aaggaaacag tgtcttctgg gcaacactct ctgggtgacc tagctgtatg
      361 aacaagtggc ccaaccactc cacaccttaa gttccctggt caagaggaaa tcctaccttt
      421 gccccacccc cagcacagag aaggactcaa agatatattc aaggaggagc ttttcaccga
      481 gacgtgtgaa caagtgtgac agcaaattgt tgttattatt ctgttgttac aacggacaca
      541 cacaattttc cggatcccct acagccaacc ctgcccccgc actagagact gtgtgccaac
      601 cccgcccctg agccacctca ggccagcagt gccaggagcc aggctggtgc ctgaacatct
      661 cagtttgagg gaggaggctt ggatcaggat cctgtgcctg aagccaagtc agtcactcac
      721 gtctttgctg gctctcaagg aacctccaag cggacagagc acctcttctg gccaccatga
      781 gcaccaccac agggcctgaa gctgcaccca aaccaagtgc aaagtctatc tatgagcaga
      841 gaaaacgtta ctccactgtg gttatggctg atgtgtccca gtatcatgtc aatcacctgg
      901 tcaccttctg cttgggggag gaagatggcg tgcacactgt ggaagatgct tccagaaagc
      961 tggcagtcat ggacagccag gggcgtgtct gggcacagga gatgctactg agagtgtcac
     1021 ctggtcatgt cactctgctt gatccagtct ctaaggagga actagagtca tatcctctcg
     1081 acgccatcgt acgctgcgac gcggtgatgc cccgaggacg gagccgctcg ttgctgctcc
     1141 tggtgtgcca agagccagag cgtgcacagc cagatgtcca tttcttccag ggcctgctcc
     1201 tcggggcgga gctgatccgt gaggacatcc aaggggctct gcagaactac cgctccggac
     1261 gtggggaacg cagggcggca gcactcaggg ctacgcagga ggagctgcga cgcggtgcct
     1321 ctccagcagc ggagaccccg cccttacagc gtcgcccttc tgtccgcgcg gtgatcaaca
     1381 cggtggaacc atccgcggtg cgcgggcgac cccaagtgga gccaattcca gagactgagg
     1441 aagcgaggaa acccgaccca gcgcgcacga cgactaggag ctctgatcct acctccccag
     1501 acctgggccc aaggggtcct gagctggccg gtctgcaggc ggagcgggat gtggatatcc
     1561 tgaaccatgt gtttgacgac gtggagagtt ttgtatccag actgcaaaag tcagcagagg
     1621 ctacccgggt tttggagcac cgtgagcgcg gccgcaggac acgacgccga gctgctggag
     1681 agggcctgct gaccctaagg gccaagccac ccacagaggc tgaatacact gatgtgcttc
     1741 agaaaatcaa atacgccttc agtctgctgg cccggttgcg gggcaacatc gccaacccct
     1801 cctctccaga gctgttacac tttctgttcg gacctctgca gatgattgtg aacacttcag
     1861 gcggccctga gttcccgagg agtgtgcgac gaccacattt gaccttggag gctgtggcgc
     1921 tgctccgcga caatgtcact cctcgtgaaa atgaactatg gacctcactg ggggactcct
     1981 ggacccgccc aggggtggag ctgccccctg aagaagggtc tccatacagt ccggaattct
     2041 acagcggttg ggaacctccg gccactgacc cgcagggccg cccctgggag gacccagtgg
     2101 aaaaacagct acagcacgag aagcggcgca ggcagcaaag cgccccccaa gtcgcggtca
     2161 atggtcatca agatccagaa ctggaaactg agtcccagct agaagagaaa gccagaaaat
     2221 gggttctgtg taattatgac ttccaggccc gaaatggcag cgagctatct gtcaagcacc
     2281 gagatgtgtt ggaggtcctg gatgacaggc gcaaatggtg gaaggttcgg gaccatcaag
     2341 gacaagaggg ctatgtaccc tataatatcc tgacacccca ccctggacct caggtgcact
     2401 gcagccaaag ctccgcaata aacctagaga ctagcccacc tcctccccca cctgctgcag
     2461 ctccagcccc cactcaggtg cggccccagt gggacagttg cgacagtcta aacagtttgg
     2521 atcccagcga caaggagaaa ttttcccaga tgctttgtgt caatgaggag ctgcaggcgc
     2581 gcctggcgca gggccgttcg ggtcccagcc gggtaacccc ggggcttcga gccccggagc
     2641 cccagctcag cccacgctct gaggcctcgg tggtccgtgc ctggctgcag accaagggct
     2701 ttagctccgg gactgtggat gcgcttggag tgctgactgg cgcacagctg ttctcgcttc
     2761 aaaaggaaga gttgcggtcg gtgtgcccgg aagaaggggc gcgagtatat agccaagtca
     2821 ctgtgcagcg ggcgctactg gaggacagag aaaaagtatc agagctggag gccgtaatgg
     2881 agaaacaaaa gaaaaaagtg gaaggcgaga ccaaaacaga agtcatttga tcctggttca
     2941 ttcataaaaa gtgatgagat ggtggggttc ccagcgcccc gaaagacaac agtcaccaga
     3001 ctcctccccc aacgtcagta gcagtagatg ccgtaaagga ccgcccaccc tgggttcccc
     3061 gcggtcctgg cgggcggact gcattgacag tgctgaccgg aacctttcca gagggactga
     3121 tgggaatggg gaagggaaca gagcatggac actactagaa aggcacgccc aagaggcgcg
     3181 atgatggccc tgtgcgttgt gatgcgctat aaacagcctc cttttaggct atgtccacct
     3241 gctgtccccc cccacacaca ccccctctct tgccggccac caagatgcca ggaatctaga
     3301 agacatccat attttctctc cacaaacctg gagattccaa cccaggcttc ctcttaagca
     3361 ccaatctatc cttgctctaa cactatctac aatctctctc tggttcaaaa tcctttcctg
     3421 tcaactagcg tgaggcctgg gattttcctt tcaaaggcag agggtgtctc cttccacccc
     3481 ccattttggg tcaacccctc caatcacagg catttccgca cttactgctt ctgctggttg
     3541 gagcagcttc catcaatgtg gctcaactca cctacattcc atggatgcct gtgccagcca
     3601 ctaaggattc agctatgaag atcgggatgc tataggctct tgggtcttcc agtccccaga
     3661 actttctccc tgccaagtcc tgcaacttgt ctggtttatt taggtggcta gtaagagctg
     3721 gttttctcat tgagactaga tacccctaag gttttttttt ttcctgctgt ggcacttccc
     3781 tttgcatccc taaaacactt caagagtcac accagtgcag ttggcctctg ctctccaggc
     3841 agttcagctc ttacctgagc caccagtggc acacctcaaa tccaagctag aaaagccagc
     3901 ctttgggctg acagcttcac tatacccact ttgctccaga acactatcca caatagatct
     3961 ctttcccact tcctgtctac ctctcaagca tgtctcttgg cttctcccga cagatgggat
     4021 aaaacctaac cccagcatga aagttgatat acatgaccac tccaggttca gggccctctt
     4081 cctccctttt caggacccca agcattggtt cgtgctgttg gctctgctag gaatgtcctg
     4141 gccttttgga gtctaatcac tgcctgtcgt tccttatgtc agggttgggt ggttagttgg
     4201 ttgattggtt ttgttggaga tagtctggat atagcctcaa agtctcaatt ctgtttcagt
     4261 ttcctgcatg ctgagattcc tggcagatgc cctcctgcct tcttttctaa gaaacttaaa
     4321 aacacaagca gtttgcccaa actgtttttg actctgcagt gagctcccag gctccaggct
     4381 gcaggctgcc gtgcaggcag ggaccagctg gcttgctgga acaccagatg cctctagctc
     4441 tctatggtct ggaatctgat catttctatc tgcttatcct gacttcatcc tttgttgatc
     4501 accctgtccg tcactcctcc aatctgtatc gatgttcaga catagggacc tgttacaact
     4561 caagtcagat ggcagtctgc tggccagacc tcccacctca gagctcaagt ccttagtaga
     4621 gccacatccc tgcacaaagc cagcagcact tcaacacttc ctctgctatt cagccccaag
     4681 tttcttcctg caccttagca tgccaggcct actctaccct atgacctttg catctcatca
     4741 ctgaaaatgg gcttccttca gacatatggc tcactctgct accttctagt tccacgtgtc
     4801 atgtcttggg tctactttga ctaccataaa caccatacat acacaccaga tacataccca
     4861 acatacacca taaacatcag ccatgccacg caccacacaa aatgcacacc acacacacac
     4921 cgtccacccc tgacaacacc catccaccca catccacttc ccttctcttt ctccacagca
     4981 ctacagctga aatccataca ctagttacct ctctcctgca gaacctggct cctggcctaa
     5041 gctactcact cttgggactc cagtaggtag gacagagccc agctggtagt gtaggcagtt
     5101 gctcctgact ataagaatga aggtacaatg aatcacaaga ctgcctccta ctattccagc
     5161 caatgtggcc gtggaggact gagggaactc accatcactt attcatttcc cagagaagtt
     5221 acacttgtgg agttttctgt gatccatccc acattttcaa tgtcagccat taactccact
     5281 cctttcaggg gaactgaggg caaatctggg cactccagcc ccttatcaca gcaccatggg
     5341 cttccttctg acccttccca cctcatctgg gatcctttgc tccagctgct cacttagcaa
     5401 ggtgccctcc ctactcctgt gagcacgctc caaccttgcc tccaactgta cctaccccat
     5461 ccaaatgggc ttggtcagcc tgagtcaaca agcagaacaa gtcactgagt ggcaatgtca
     5521 cgactttatt tatggtgcct gtgctttgtc tcaaaaatac cttctcctcc tccccagaca
     5581 ataggtgggg aggaggcagc aaaaatagaa catccctccc tattgcacat ggaccctata
     5641 tacaggccca cctggcagag gccagtggga ctcttggcac attcctggtc cctgctgggg
     5701 agggggggag gagtgctggg tagcatcaca cgtgaggtgg gaccctgggg caaccactct
     5761 gcttctggat acttatcttt gcatttcttg gtccttgttt ccttcttggt cccatctctg
     5821 atgctcagag caacatctca gcaacatctc cctacctggc tcagcctccc acctctatcc
     5881 tgacctcaga gaaccccttg gttcctgggg actctgtgct ttcctcccgg ttctgaggtc
     5941 ccgagaggtt atggcttctc agcaacttcc cccagagcct tgtcactcat gttcacgcgg
     6001 gggaaagggt gcgtgtgtca gaagcagcag tataaatatg gtgcggg
//
LOCUS       NM_001437581            5415 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 8, mRNA.
ACCESSION   NM_001437581 XM_063265617
VERSION     NM_001437581.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5415)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5415)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5415)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5415)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5415)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5415)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5415)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5415)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5415)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5415)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063265617.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.1519516.1,
                                           SRR26643429.2185.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-311             JAXUCZ010000001.1  130337632-130337825 c
            312-515             JAXUCZ010000001.1  130317243-130317446 c
            516-647             JAXUCZ010000001.1  130293170-130293301 c
            648-867             JAXUCZ010000001.1  130290825-130291044 c
            868-927             JAXUCZ010000001.1  130289823-130289882 c
            928-1115            JAXUCZ010000001.1  130277028-130277215 c
            1116-1242           JAXUCZ010000001.1  130267560-130267686 c
            1243-1369           JAXUCZ010000001.1  130263566-130263692 c
            1370-5415           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5415
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..311
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             258..1739
                     /gene="Mef2a"
                     /note="isoform 4 is encoded by transcript variant 8;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 4"
                     /protein_id="NP_001424510.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIP
                     PSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTS
                     ADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINI
                     KSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSSSS
                     YDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    258..>962
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    258..>962
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    <630..>1367
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <630..>1367
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            312..515
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            516..647
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            648..867
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            868..927
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1115
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1242
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1369
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..5415
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcgatt
      121 tttaagacaa tttcagcggc agccttggac tggaaggtta aataatagga actgtgtacg
      181 atgcattagg atattgaaga aaattagctt ctgaattaat tatttggaat ataaggaaga
      241 aaaggtgact tttgaaaatg gggcgaaaga aaatacaaat tacacgcata atggatgaga
      301 ggaaccgaca ggtgactttt acaaagcgaa agttcggatt gatgaagaaa gcctatgaac
      361 tcagtgtgct ctgtgactgt gagatagcac tcatcatctt caacagctct aacaagttgt
      421 ttcagtacgc cagcactgac atggacaaag tccttctcaa gtacaccgag tacaacgagc
      481 ctcatgaaag caggacgaac tcggatattg tggagacttt aagaaagaaa ggccttaatg
      541 gttgtgagag ccctgatgct gacgattact ttgagcacag tccactctcg gaggacagat
      601 tcagcaaact aaatgaagat agtgatttta ttttcaaacg aggccctcct ggcttgccgc
      661 ctcagaactt ctcaatgtct gtcacagtcc ctgtgaccag ccctaatgct ttgtcgtaca
      721 ctaacccagg gagttcactc gtgtcaccgt ctttggcagc cagctcaaca ttagcagagt
      781 ccagcatgct gtctccaccc ccagccacgc tacatagaaa tgtgtctcca ggagctccgc
      841 agagaccacc aagcactggc agtgcaggtg ggatgttgag cactacagac ctcacggtac
      901 caaatggagc tggaaatagt cctgtgggga atggatttgt aaactcaagg gcctctccaa
      961 atttgattgg aaatactggt gcgaatagtg taggcaaagt catgcctaca aagtcccccc
     1021 cgccaccagg tgggggcagt gttggaatga acagtcggaa accagatcta cgggttgtca
     1081 ttcccccttc aagcaagggc atgatgcccc cacttaatgc ccaaaggata agtagttctc
     1141 aagccacaca acctcttgcc acgcccgtgg tgtctgtgac aactccaagc ttgcctccgc
     1201 agggactagt gtactcggcc atgccgacag cctacaacac tgattactca ttgaccagcg
     1261 ctgacctgtc cgccctgcaa ggctttactt cccctggaat gctgtctctg gggcaggctt
     1321 cagcctggca gcagcaccat ctaggacaag cggccctcag ctctctagtg gctggagggc
     1381 agttatctca gggttcaaat ttgtccatta acaccaacca gaacatcaac attaagtcag
     1441 agccaatttc acctccccgt gatagaatga ccccatcagg cttccagcag cagcagcagc
     1501 agcagccaca gcagcaacca ccgccacaac ctccacagcc ccagccccaa ccccggcagg
     1561 aaatggggcg ctcccctgtg gacagtctga gcagctctag cagctcctac gatggcagtg
     1621 accgggagga tccacggggc gacttccatt ctccaattgt gcttggccga cctccaaatg
     1681 ctgaggacag agaaagcccc tctgtaaaac gcatgaggat ggacacatgg gtgacctaag
     1741 gcttcctggt tcatgtctgt tctttgtgtt actgcagtga actgccctac atatcttaaa
     1801 ttggtgaata aggacatgag ttcaatatat ttatatgtac atgcatacat atatatccct
     1861 ttacatatat atgtatgtcg gtgtgagtgt gtgtatgtgt gggtgtgtgt tgcatacaca
     1921 gaatcaggca cttactgcga ctccttgtag gtatgcagat gtgtgcacac ggcacacaga
     1981 gcaccttgta gagacagacc agcctggcac ttccttggac tacttgtctc ctaagataaa
     2041 gtttttgcag agaaacgtgt acccatatat aattcttcca cattagcctg cagaaaccta
     2101 ggggccccta tttgttttat ttacctgtgc ggtgactgta gttacttcaa aaaaaaaaaa
     2161 aattgctttg tagaacagag cagtagaaaa gcaggaacca agaaagcaat actgtacata
     2221 aagtcattta tattaataac ccaacctggc atgggtctat tgcagagggg tgcatgggca
     2281 agggctgtct atattaaaca gacacagtaa acaaagagcc ccacacataa ctgttttgca
     2341 cgtgcaaaaa aatgtattgg gtcaaagaag tgatttttag ctattaaaaa gagagaatag
     2401 aaaacacgca tgaaatattc agaaatacta gcctagaaat atagagcatt aacaaaataa
     2461 aattaatata ttaagttata attggaatat gtcagaagtt tcttttacat tcatatcttt
     2521 aaaaattaaa gaaactgatt ttaggtcatg tatattttat atgaaagaaa acacccttaa
     2581 tgaattgatg actatatata aaattatatc cactactttt gaacacattc tgctgaatta
     2641 tttatataag ccaaagctgt atgttgtaac tttttttttt aaagaatagc tttatcttgt
     2701 tttaactttt tagttttatt ttaagaggga agaaaaaaac aaaaatatct tgcaagcaga
     2761 accttggaaa aaaaaaagcc atgaacatta ttattctata tgtaaattaa aagtcgagcc
     2821 aaactctttg tgtatatagc atcttaaata tattaccacc tttgatgtaa gtacctatgt
     2881 attgtatggt caccagatta aaaagtatat ttttgtggat tgccaccaat ttggggggaa
     2941 aggcgaagtc cttaagtaga gtattcactg tttaatattt actattttgt taaatatact
     3001 gtactttgga ttttaattat tagcccagtt tttcagagga ttgtgtaaag gggtttcccc
     3061 tcactggtgg tgaatgtgtg atgttctgtt gtaatctttg tgctgtatgg ggtgagcatc
     3121 attatatatt ttatatgtgt acataaatag caaagtggca aaaaaattgg tgttaagttc
     3181 atcctgcata aatataaaat gtgttgtaac agattttata aggcattatt taaaacttgc
     3241 cttttgtgag ggaaaaaaaa aaacagtaga aagatgacct aatttaacta atattagaga
     3301 aaatggctga gtagtagatg agcacaaagg ttttataagt ggtaaataat taggaaaata
     3361 tttgtagggg aagggatctt ttctccttga ctctaaagat agaatgatgc agctggttac
     3421 aaaatccagg agggctttag cgtcccgtgc gtgggaaggc acgggcgtgc agggagcagc
     3481 tctcctatgg tgcagatccc cgacacaatt cttgctgtcc tgacggaaac tggtgccacc
     3541 ctcagcttgg attttgaaca aggccttact cttacaggga gacagctcgt tggtgatggc
     3601 aagttcatcc gtttactggg cttgtgccat gaacaaaatt caaagtcctg tatatctttt
     3661 atcctagatt tttaaatact ccttttcctg aaaaaactta aagagtttaa aaatggctgc
     3721 tattttatac tgaacaatgt tgagcagcta cctgcagttt ttacttacat tttgcttttc
     3781 ccctcgattc cctaaattat gctccttttg atgtctcctc atctgctgtc ccgacagctc
     3841 atcagccagg tttcctgcct ggccgcacac aggtattcgg tccatgcacc gtggtgagca
     3901 caggctgtgc actggagagc ctcactgaca gtctgggtag cacatgttag tggaagccaa
     3961 ggaagtgggg acggtgtctc atctcctctg tggtctcagc acttggctct tcctcagaga
     4021 aggttaggtt ttcttcctca agtgtactga gttgacttac aggcacgttc ctcataaggt
     4081 cacagtctcc caacactgac tttccaagat accccttacc actttgtaaa ccatttatag
     4141 ctttgaaagt attaagtgac cctttcatta ttatttatgc atgttcatga acttctgctg
     4201 tatattggga taggagttaa cacattcaca tttactgtct attttcttgt gtgccttatg
     4261 agatggcttc tctgactgta tctcaatagt ctttctatgc aggtttataa tcagtacaac
     4321 tactgttttc taaaggaata ttacacacgg ctcggagttt gtacttaaat tacactgacc
     4381 aagtcacaat gtattccgtt ttcaggaact gaatatctga ctgttaatct tttcccatat
     4441 gcccagtgtg atctggagca tatgggtctg acatccttca cccagatgct catgtgtgaa
     4501 cacatccaca tccacagctc tcagtggaag ccagcctaga gtagggagga cactgacggt
     4561 gttgctttaa actgactttt cttacccttt gagactcatg tgttttgtat aagacaccat
     4621 cacaagaaag ttttctccct tcagataaca tattttatta ttaaaaagaa aaacaaaaaa
     4681 agcttttaag ttgcactgga cgtgggccgt tccttcggaa ctctttggat ctacactgag
     4741 agtgagtgtc gccgctctgt gaacacaggt ggtcccagtc aaaactccat cctttgagcc
     4801 ctaattacat ccattgtgtt acaaaactaa atcaggggtt tgttctaaaa gaacaataca
     4861 tgtctcacca tttcctttca actgtaaaga cgactgataa tgtattaaca taatttctgt
     4921 attaaccatc atgcgcacaa gaaatacata gtaaatacgg aacctgaaaa ctcctgcatc
     4981 ggatcataaa agctagatga ttagaatgtg aaaagaactt tacagatgta aaacttttat
     5041 ttctctgtag aaactttctt cactttgctg tgcaagaaga cactgctttg ctatatttaa
     5101 aatggctttt ttaaaaagag atttatgtat ttggtaaatg tttgtagtca acagttcaca
     5161 caaagaagct gtacacggtt tgatcatgta aaaccgtttg gcggcacaag ctggactttg
     5221 ttgccatcct tgagatgaac cttttaagaa aaataagtta atctcaattt ttccctgaat
     5281 gtgttgtttt ttcttcatta tacaataaat attatagtga agtttttatc aaatggttaa
     5341 gacaatgcta gaggttgttg taagctattt gtctcctgca ctcactccag taaagatggc
     5401 ctggctttga ccata
//
LOCUS       NM_001437557            4294 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 9, mRNA.
ACCESSION   NM_001437557 XM_063287219
VERSION     NM_001437557.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287219.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1038786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-596             JAXUCZ010000001.1  254857203-254857295
            597-3453            JAXUCZ010000001.1  254857400-254860256
            3454-3507           JAXUCZ010000001.1  254860529-254860582
            3508-3565           JAXUCZ010000001.1  254861917-254861974
            3566-3703           JAXUCZ010000001.1  254865878-254866015
            3704-3770           JAXUCZ010000001.1  254866108-254866174
            3771-3892           JAXUCZ010000001.1  254866293-254866414
            3893-4044           JAXUCZ010000001.1  254866843-254866994
            4045-4294           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..4294
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4294
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4148
                     /gene="Pprc1"
                     /note="isoform 9 is encoded by transcript variant 9;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 9"
                     /protein_id="NP_001424486.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVEMSLADSPWDFSPPPFLETSSPKLPSWR
                     SSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPEEED
                     KSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLPEGC
                     VVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGTEDG
                     VPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKKKKK
                     EQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGKPRA
                     WARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSARAD
                     SIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVAIPT
                     SNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPSLEP
                     SDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDRNSQ
                     PPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSPTPE
                     PSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLPPLL
                     PLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYSCLP
                     PPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPFWST
                     VSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAEPTK
                     LEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRPREK
                     PISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGIEAS
                     DLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSSCSSSGRSRRCSSSSSSSSSSSSS
                     SSSRSRSPSVSPCRRSDRRRRYSSYRSNDHYQRQRVLQKERAIEERRVVFIGKIPGRM
                     TRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPF
                     DLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1152..2549
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1152..2549
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1908..3365
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1908..3365
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3774..4046
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    3774..4046
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..596
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..3453
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3507
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3565
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3703
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3770
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3892
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4044
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4294
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggttg
      601 agatgtccct tgcagattct ccgtgggact tctctccacc tcctttcttg gaaacttctt
      661 cccctaagct gcctagctgg agatcctcaa gaccaagacc tcgatggagt cagtctcctc
      721 ctccccagca gcgcagtgat ggagaggagg aggaagaggt tgccggcttc agtggtcaga
      781 tgcttgatgg cgaacttgac aactcggtga ataccttgga tttccccatg cacctggcat
      841 gccctgagga agaagacaag tcaggggcag caaatgtggc agtgtcagca cctggtgacg
      901 agagcatctc ctccttgagt gagctggtac gggccatgca cccctactgc ttacccaacc
      961 tcacccagtt ggcatcactt gacgctgagc ttcaggagca ggctgatgat ctgacactgc
     1021 ctgagggttg tgtggtgctg gagattgtgg gccaggcagc cacagctggt gatgacctgg
     1081 agatcccagt ggtcgtgcgg cagattcctt caggatccca gtctgtgctc ctagatgggt
     1141 ctgtagggac tgatcctgcc ttgcagctac tcatgcccgc catggagcct ggaacagaag
     1201 atggtgtgcc taaagtcgct ccttgccctg atcaagaatt accactgagc tctgcctgct
     1261 tattggagcc cagggacatc atggagtcat tggcccccaa ggagcctcgg aacctacctg
     1321 ccaatgcaag tgagggttct cagagagttc ccagaaaggg taggaagaag aagaagaagg
     1381 agcagccaac agcctgtttg gaaggctgta ccaggaggct gaggtcatct tctcgtggac
     1441 agtctactgt ggctacagag gtgaactctc aggcaggcaa cttacagaaa cagcctcagg
     1501 aagagcttca gagagagact gcggcccctc agagcagagg gaagccacgg gcttgggctc
     1561 gggcctgggc agctgccttg gagaaaactg ggtctgaaga cccagaggac cagaatgcag
     1621 gacaggatag tcctgctgag gaagatgttc tagaactccg tcctaagctg gtggagacta
     1681 gccaagccga ccccacgctc tcactaaacg actctgctcg agctgactcc atcccagtta
     1741 actctgttga aggtgactcc actgcagtgg acactgctgt acctgttgac caggcttcat
     1801 cttgtacaga gctggttggt tctctctcag gaggcccaat tctgagtagc ccagtcctag
     1861 atgacaggac aggagttgaa cctgcagtgg ctattcccac ttcaaatcac ttgtctccag
     1921 ctgatgctat cctagctaac ccagggacag ctgaccctgc tccaaatggc ctggctccag
     1981 gagatcctgt gctagttaag tgcagaccaa ctgatcctag acgtgcagct gctgctgcca
     2041 ctgctgctca ggggcctcgt ccttccctag agccctcaga ccatcctaag gtcatcaccc
     2101 ctgaagtcaa ggatgctgga ggtcctctga aggtggaagg tagtaccagt gctacaaccc
     2161 aggaagccag acctcggccc ctcagcctat ctgagtaccg tcaacgacgg cggcaacggc
     2221 aaatagaagc agaagacagg aattctcagc ccccagctgg aaagtggcca agtctcccag
     2281 agacgcccaa agggctggca gatatccctt gtcttgttcc atcagcccca accaagaaga
     2341 cagccccaca gagaagccct atagctgtac cagagacttg ttctgtatct gtgggttcta
     2401 accctgtttc ccctactcct gagccatctg caagcaaact tatggtttca actcactctg
     2461 aacaggtgtc atctcatgag atgccacttc cagttagact tccccctcct acattgcagt
     2521 ctatggctcc tgctgggccc accccttcta cagtgcccac gccattgcct ttccctccga
     2581 gcttacctcc tctgcttcct cttcctgcaa gtggtcctgg tgtccccagc ctgcccccac
     2641 ctcctttgca acctcctgga cttccagtat caatgagaca aatgccacct gacccctata
     2701 ctcagtatgc ccctgtgccg ccctggcctt gttacccctc tgtatctcct tctggctatt
     2761 cttgtctgcc cccaccacca gcgatgccca tagtgtcggg tacccctggt acctatgctg
     2821 tacccccaac ttgcaatgtg ccttgggtac cccctcctgc accagtctca ccttatagct
     2881 ccagctctgc ctatgggtcc cttgggtggg gcccagggtt gcaacagcct cccttttggt
     2941 ctactgtttc tccacctcca ttgtcttcag cctctactgg tagagctgtt cccccaccca
     3001 gtgtggaacc cagtaacagt tcagctggtc ctccggaaga tacacttcct gtgccagtga
     3061 ccccttccct gagctctcgg ccagccagcc ccatagctcc accagcagaa cctacgaagc
     3121 tggaggctca gccagtgcct gtctctcccc aaccgaaaca caaagtgtcc cctgtggtac
     3181 agagtcccca gatcaaggtt ctaccaactc tgtctgctga gggcgtggct attggggaat
     3241 ctgaatcaga gaggctaaag ccggagaccc aggagaacag accaagggag aagcctatct
     3301 ctacggctac gaaggctgtt ctgttaccaa agcagagcac tgtcgcaaaa ctgcctgccg
     3361 tccatccagc ccggctaagg aggctgtcct tcctgcccac cccacgtgct cagggttctg
     3421 aggatgtggt gcaggcattc atcagtgaga ttgggattga agcatcagac ctgtccagtc
     3481 tgttggagca gtttgagaaa tcagaagcca aaaaggagtg tcctctcccg gctcctgctg
     3541 acagcgtggc tgtaggaaac tcagggtcca gctgcagttc ctctggacgg tccagaagat
     3601 gttcctcctc ttcctcttct tcctcctcct catcttcatc atccagttcc agaagccggt
     3661 ctccctctgt gtccccttgc aggagaagtg accggaggcg gcggtacagc tcttaccgtt
     3721 caaatgacca ttaccaaagg cagagagtac tgcagaagga gcgtgcaata gaagagagaa
     3781 gggtggtctt cattgggaaa atacctggcc gcatgactcg gtcggagctg aagcagaggt
     3841 tctctgtttt tggagagatt gaggagtgta ccattcattt tcgtgtccaa ggtgacaact
     3901 atggtttcgt cacttaccgg tatgctgaag aggcatttgc agccattgag agtggccaca
     3961 agttgcggca ggcagacgag cagccctttg atctctgctt tgggggccga aggcagttct
     4021 gcaagaggag ttactctgat cttgactcca atcgggaaga ctttgatcct gctcctgtca
     4081 agagcaaatt cgattctctt gactttgata ctttgttgaa acaggcccag aagaacctaa
     4141 ggaggtaacc ctgggctttc ctcccccatc cattttctct ggaggtgtcc aacctctcaa
     4201 ccccctcccc tactctaggg gagagagctg ctagtgtgga aagactttta taaggaaatg
     4261 aaaaaaagtt aaataaaaat atgttaaatc ggga
//
LOCUS       NM_001437579            5626 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 6, mRNA.
ACCESSION   NM_001437579 XM_063265606
VERSION     NM_001437579.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5626)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5626)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5626)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5626)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5626)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5626)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5626)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5626)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5626)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5626)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063265606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2697796.1,
                                           SRR26360190.448937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000001.1  130391566-130391834 c
            270-322             JAXUCZ010000001.1  130365401-130365453 c
            323-516             JAXUCZ010000001.1  130337632-130337825 c
            517-720             JAXUCZ010000001.1  130317243-130317446 c
            721-858             JAXUCZ010000001.1  130292969-130293106 c
            859-1078            JAXUCZ010000001.1  130290825-130291044 c
            1079-1138           JAXUCZ010000001.1  130289823-130289882 c
            1139-1326           JAXUCZ010000001.1  130277028-130277215 c
            1327-1453           JAXUCZ010000001.1  130267560-130267686 c
            1454-1580           JAXUCZ010000001.1  130263566-130263692 c
            1581-5626           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5626
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..269
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            270..322
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            323..516
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    451..453
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             463..1950
                     /gene="Mef2a"
                     /note="isoform 3 is encoded by transcript variant 6;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 3"
                     /protein_id="NP_001424508.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPD
                     TSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPG
                     SSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPN
                     GAGNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVV
                     IPPSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSL
                     TSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNI
                     NIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSS
                     SSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    466..696
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    466..696
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(466..474,478..480,484..486,499..501,505..507,
                     517..522,529..534,538..543,550..555,559..564,574..576)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(466..474,478..480,484..486,499..501,505..507,
                     517..522,529..534,538..543,550..555,559..564,574..576)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(523..525,544..549,556..561,565..570,577..579,
                     592..594,598..600,604..606,622..624,628..630,646..648,
                     655..660,667..669,676..681)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(523..525,544..549,556..561,565..570,577..579,
                     592..594,598..600,604..606,622..624,628..630,646..648,
                     655..660,667..669,676..681)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    637..639
                     /gene="Mef2a"
                     /note="Phosphoserine, by CK2. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     phosphorylation site"
     misc_feature    637..639
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    637..639
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    751..924
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    751..924
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    754..756
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    <847..>1578
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <847..>1578
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    985..1137
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1099..1104
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     misc_feature    1165..1167
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1186..1275
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1207..1209
                     /gene="Mef2a"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1225..1227
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1258..1311
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Required for interaction with MAPKs.
                     /evidence=ECO:0000250"
     misc_feature    1372..1374
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1393..1395
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1501..1503
                     /gene="Mef2a"
                     /note="Phosphoserine, by MAPK7.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1606..1947
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1645..1647
                     /gene="Mef2a"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1660..1662
                     /gene="Mef2a"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1681..1683
                     /gene="Mef2a"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q60929; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1783..1785
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1822..1827
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     exon            517..720
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            721..858
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1078
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1138
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1326
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1453
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1580
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..5626
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccgggg ggcggcgggc gcggcggcgg gggcccgccg gagccgtcgt gagtctcctc
       61 cctgggcgcg ccacctctgg ggccccccgc cgcgccgccc cgctcctccc tgaaagttga
      121 cggagttccc agggggctgc ggagccactc ggtccgttcc tccagcatcg cgaacctcgg
      181 ggtctccccg ttcggtagac agtcagtacg gggggcgtcc ggccctgtgg tcgcacttaa
      241 agttcccccg cttctgcttc gtggggaagg aattgcatct tgtggaaaag gaacaaagaa
      301 gaactttctg caaggataaa atatttttaa gacaatttca gcggcagcct tggactggaa
      361 ggttaaataa taggaactgt gtacgatgca ttaggatatt gaagaaaatt agcttctgaa
      421 ttaattattt ggaatataag gaagaaaagg tgacttttga aaatggggcg aaagaaaata
      481 caaattacac gcataatgga tgagaggaac cgacaggtga cttttacaaa gcgaaagttc
      541 ggattgatga agaaagccta tgaactcagt gtgctctgtg actgtgagat agcactcatc
      601 atcttcaaca gctctaacaa gttgtttcag tacgccagca ctgacatgga caaagtcctt
      661 ctcaagtaca ccgagtacaa cgagcctcat gaaagcagga cgaactcgga tattgtggag
      721 gctctgaaca agaaggaaca cagaggctgc gacagcccag accctgatac ttcatatgtg
      781 ctaactccac atacagaaga aaaatataaa aaaattaatg aggaatttga taatatgatg
      841 cggaatcata aaatcgcacc tggcttgccg cctcagaact tctcaatgtc tgtcacagtc
      901 cctgtgacca gccctaatgc tttgtcgtac actaacccag ggagttcact cgtgtcaccg
      961 tctttggcag ccagctcaac attagcagag tccagcatgc tgtctccacc cccagccacg
     1021 ctacatagaa atgtgtctcc aggagctccg cagagaccac caagcactgg cagtgcaggt
     1081 gggatgttga gcactacaga cctcacggta ccaaatggag ctggaaatag tcctgtgggg
     1141 aatggatttg taaactcaag ggcctctcca aatttgattg gaaatactgg tgcgaatagt
     1201 gtaggcaaag tcatgcctac aaagtccccc ccgccaccag gtgggggcag tgttggaatg
     1261 aacagtcgga aaccagatct acgggttgtc attccccctt caagcaaggg catgatgccc
     1321 ccacttaatg cccaaaggat aagtagttct caagccacac aacctcttgc cacgcccgtg
     1381 gtgtctgtga caactccaag cttgcctccg cagggactag tgtactcggc catgccgaca
     1441 gcctacaaca ctgattactc attgaccagc gctgacctgt ccgccctgca aggctttact
     1501 tcccctggaa tgctgtctct ggggcaggct tcagcctggc agcagcacca tctaggacaa
     1561 gcggccctca gctctctagt ggctggaggg cagttatctc agggttcaaa tttgtccatt
     1621 aacaccaacc agaacatcaa cattaagtca gagccaattt cacctccccg tgatagaatg
     1681 accccatcag gcttccagca gcagcagcag cagcagccac agcagcaacc accgccacaa
     1741 cctccacagc cccagcccca accccggcag gaaatggggc gctcccctgt ggacagtctg
     1801 agcagctcta gcagctccta cgatggcagt gaccgggagg atccacgggg cgacttccat
     1861 tctccaattg tgcttggccg acctccaaat gctgaggaca gagaaagccc ctctgtaaaa
     1921 cgcatgagga tggacacatg ggtgacctaa ggcttcctgg ttcatgtctg ttctttgtgt
     1981 tactgcagtg aactgcccta catatcttaa attggtgaat aaggacatga gttcaatata
     2041 tttatatgta catgcataca tatatatccc tttacatata tatgtatgtc ggtgtgagtg
     2101 tgtgtatgtg tgggtgtgtg ttgcatacac agaatcaggc acttactgcg actccttgta
     2161 ggtatgcaga tgtgtgcaca cggcacacag agcaccttgt agagacagac cagcctggca
     2221 cttccttgga ctacttgtct cctaagataa agtttttgca gagaaacgtg tacccatata
     2281 taattcttcc acattagcct gcagaaacct aggggcccct atttgtttta tttacctgtg
     2341 cggtgactgt agttacttca aaaaaaaaaa aaattgcttt gtagaacaga gcagtagaaa
     2401 agcaggaacc aagaaagcaa tactgtacat aaagtcattt atattaataa cccaacctgg
     2461 catgggtcta ttgcagaggg gtgcatgggc aagggctgtc tatattaaac agacacagta
     2521 aacaaagagc cccacacata actgttttgc acgtgcaaaa aaatgtattg ggtcaaagaa
     2581 gtgattttta gctattaaaa agagagaata gaaaacacgc atgaaatatt cagaaatact
     2641 agcctagaaa tatagagcat taacaaaata aaattaatat attaagttat aattggaata
     2701 tgtcagaagt ttcttttaca ttcatatctt taaaaattaa agaaactgat tttaggtcat
     2761 gtatatttta tatgaaagaa aacaccctta atgaattgat gactatatat aaaattatat
     2821 ccactacttt tgaacacatt ctgctgaatt atttatataa gccaaagctg tatgttgtaa
     2881 cttttttttt taaagaatag ctttatcttg ttttaacttt ttagttttat tttaagaggg
     2941 aagaaaaaaa caaaaatatc ttgcaagcag aaccttggaa aaaaaaaagc catgaacatt
     3001 attattctat atgtaaatta aaagtcgagc caaactcttt gtgtatatag catcttaaat
     3061 atattaccac ctttgatgta agtacctatg tattgtatgg tcaccagatt aaaaagtata
     3121 tttttgtgga ttgccaccaa tttgggggga aaggcgaagt ccttaagtag agtattcact
     3181 gtttaatatt tactattttg ttaaatatac tgtactttgg attttaatta ttagcccagt
     3241 ttttcagagg attgtgtaaa ggggtttccc ctcactggtg gtgaatgtgt gatgttctgt
     3301 tgtaatcttt gtgctgtatg gggtgagcat cattatatat tttatatgtg tacataaata
     3361 gcaaagtggc aaaaaaattg gtgttaagtt catcctgcat aaatataaaa tgtgttgtaa
     3421 cagattttat aaggcattat ttaaaacttg ccttttgtga gggaaaaaaa aaaacagtag
     3481 aaagatgacc taatttaact aatattagag aaaatggctg agtagtagat gagcacaaag
     3541 gttttataag tggtaaataa ttaggaaaat atttgtaggg gaagggatct tttctccttg
     3601 actctaaaga tagaatgatg cagctggtta caaaatccag gagggcttta gcgtcccgtg
     3661 cgtgggaagg cacgggcgtg cagggagcag ctctcctatg gtgcagatcc ccgacacaat
     3721 tcttgctgtc ctgacggaaa ctggtgccac cctcagcttg gattttgaac aaggccttac
     3781 tcttacaggg agacagctcg ttggtgatgg caagttcatc cgtttactgg gcttgtgcca
     3841 tgaacaaaat tcaaagtcct gtatatcttt tatcctagat ttttaaatac tccttttcct
     3901 gaaaaaactt aaagagttta aaaatggctg ctattttata ctgaacaatg ttgagcagct
     3961 acctgcagtt tttacttaca ttttgctttt cccctcgatt ccctaaatta tgctcctttt
     4021 gatgtctcct catctgctgt cccgacagct catcagccag gtttcctgcc tggccgcaca
     4081 caggtattcg gtccatgcac cgtggtgagc acaggctgtg cactggagag cctcactgac
     4141 agtctgggta gcacatgtta gtggaagcca aggaagtggg gacggtgtct catctcctct
     4201 gtggtctcag cacttggctc ttcctcagag aaggttaggt tttcttcctc aagtgtactg
     4261 agttgactta caggcacgtt cctcataagg tcacagtctc ccaacactga ctttccaaga
     4321 taccccttac cactttgtaa accatttata gctttgaaag tattaagtga ccctttcatt
     4381 attatttatg catgttcatg aacttctgct gtatattggg ataggagtta acacattcac
     4441 atttactgtc tattttcttg tgtgccttat gagatggctt ctctgactgt atctcaatag
     4501 tctttctatg caggtttata atcagtacaa ctactgtttt ctaaaggaat attacacacg
     4561 gctcggagtt tgtacttaaa ttacactgac caagtcacaa tgtattccgt tttcaggaac
     4621 tgaatatctg actgttaatc ttttcccata tgcccagtgt gatctggagc atatgggtct
     4681 gacatccttc acccagatgc tcatgtgtga acacatccac atccacagct ctcagtggaa
     4741 gccagcctag agtagggagg acactgacgg tgttgcttta aactgacttt tcttaccctt
     4801 tgagactcat gtgttttgta taagacacca tcacaagaaa gttttctccc ttcagataac
     4861 atattttatt attaaaaaga aaaacaaaaa aagcttttaa gttgcactgg acgtgggccg
     4921 ttccttcgga actctttgga tctacactga gagtgagtgt cgccgctctg tgaacacagg
     4981 tggtcccagt caaaactcca tcctttgagc cctaattaca tccattgtgt tacaaaacta
     5041 aatcaggggt ttgttctaaa agaacaatac atgtctcacc atttcctttc aactgtaaag
     5101 acgactgata atgtattaac ataatttctg tattaaccat catgcgcaca agaaatacat
     5161 agtaaatacg gaacctgaaa actcctgcat cggatcataa aagctagatg attagaatgt
     5221 gaaaagaact ttacagatgt aaaactttta tttctctgta gaaactttct tcactttgct
     5281 gtgcaagaag acactgcttt gctatattta aaatggcttt tttaaaaaga gatttatgta
     5341 tttggtaaat gtttgtagtc aacagttcac acaaagaagc tgtacacggt ttgatcatgt
     5401 aaaaccgttt ggcggcacaa gctggacttt gttgccatcc ttgagatgaa ccttttaaga
     5461 aaaataagtt aatctcaatt tttccctgaa tgtgttgttt tttcttcatt atacaataaa
     5521 tattatagtg aagtttttat caaatggtta agacaatgct agaggttgtt gtaagctatt
     5581 tgtctcctgc actcactcca gtaaagatgg cctggctttg accata
//
LOCUS       NM_001437591            5431 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 2, mRNA.
ACCESSION   NM_001437591 XM_006228280
VERSION     NM_001437591.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5431)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5431)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 5431)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 5431)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 5431)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006228280.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.800.1,
                                           SRR26643299.1163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                JAXUCZ010000001.1  78402148-78402166   c
            20-177              JAXUCZ010000001.1  78401477-78401634   c
            178-218             JAXUCZ010000001.1  78398316-78398356   c
            219-277             JAXUCZ010000001.1  78398010-78398068   c
            278-439             JAXUCZ010000001.1  78397058-78397219   c
            440-589             JAXUCZ010000001.1  78396669-78396818   c
            590-672             JAXUCZ010000001.1  78396228-78396310   c
            673-937             JAXUCZ010000001.1  78395632-78395896   c
            938-1064            JAXUCZ010000001.1  78395199-78395325   c
            1065-1153           JAXUCZ010000001.1  78394918-78395006   c
            1154-1228           JAXUCZ010000001.1  78394740-78394814   c
            1229-1377           JAXUCZ010000001.1  78394489-78394637   c
            1378-1519           JAXUCZ010000001.1  78392927-78393068   c
            1520-1548           JAXUCZ010000001.1  78392786-78392814   c
            1549-1678           JAXUCZ010000001.1  78389932-78390061   c
            1679-1810           JAXUCZ010000001.1  78389705-78389836   c
            1811-1919           JAXUCZ010000001.1  78389331-78389439   c
            1920-2094           JAXUCZ010000001.1  78389017-78389191   c
            2095-2227           JAXUCZ010000001.1  78388632-78388764   c
            2228-5431           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..5431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5431
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..19
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            20..177
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    83..85
                     /gene="Eps8l1"
                     /note="upstream in-frame stop codon"
     CDS             161..2314
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001424520.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     misc_feature    254..646
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    254..646
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    order(275..277,512..514,572..574)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(275..277,512..514,572..574)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(470..487,533..535,602..604,614..616)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(470..487,533..535,602..604,614..616)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    1604..1762
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    1604..1762
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    order(1604..1621,1625..1627,1634..1636,1643..1651,
                     1670..1687,1691..1717,1730..1741,1751..1762)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1604..1621,1625..1627,1634..1636,1643..1651,
                     1670..1687,1691..1717,1730..1741,1751..1762)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1625..1627,1637..1645,1694..1702,1706..1708,
                     1733..1738,1742..1753)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1625..1627,1637..1645,1694..1702,1706..1708,
                     1733..1738,1742..1753)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    2027..2224
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     misc_feature    2027..2224
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     exon            178..218
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..277
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..439
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..589
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..672
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..937
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1064
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1153
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1228
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1377
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1519
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1548
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1678
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1810
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1919
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2094
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2227
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..5431
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagcc agcaggcagg agccaggctg gtgcctgaac atctcagttt gagggaggag
       61 gcttggatca ggatcctgtg cctgaagcca agtcagtcac tcacgtcttt gctggctctc
      121 aaggaacctc caagcggaca gagcacctct tctggccacc atgagcacca ccacagggcc
      181 tgaagctgca cccaaaccaa gtgcaaagtc tatctatgag cagagaaaac gttactccac
      241 tgtggttatg gctgatgtgt cccagtatca tgtcaatcac ctggtcacct tctgcttggg
      301 ggaggaagat ggcgtgcaca ctgtggaaga tgcttccaga aagctggcag tcatggacag
      361 ccaggggcgt gtctgggcac aggagatgct actgagagtg tcacctggtc atgtcactct
      421 gcttgatcca gtctctaagg aggaactaga gtcatatcct ctcgacgcca tcgtacgctg
      481 cgacgcggtg atgccccgag gacggagccg ctcgttgctg ctcctggtgt gccaagagcc
      541 agagcgtgca cagccagatg tccatttctt ccagggcctg ctcctcgggg cggagctgat
      601 ccgtgaggac atccaagggg ctctgcagaa ctaccgctcc ggacgtgggg aacgcagggc
      661 ggcagcactc agggctacgc aggaggagct gcgacgcggt gcctctccag cagcggagac
      721 cccgccctta cagcgtcgcc cttctgtccg cgcggtgatc aacacggtgg aaccatccgc
      781 ggtgcgcggg cgaccccaag tggagccaat tccagagact gaggaagcga ggaaacccga
      841 cccagcgcgc acgacgacta ggagctctga tcctacctcc ccagacctgg gcccaagggg
      901 tcctgagctg gccggtctgc aggcggagcg ggatgtggat atcctgaacc atgtgtttga
      961 cgacgtggag agttttgtat ccagactgca aaagtcagca gaggctaccc gggttttgga
     1021 gcaccgtgag cgcggccgca ggacacgacg ccgagctgct ggagagggcc tgctgaccct
     1081 aagggccaag ccacccacag aggctgaata cactgatgtg cttcagaaaa tcaaatacgc
     1141 cttcagtctg ctggcccggt tgcggggcaa catcgccaac ccctcctctc cagagctgtt
     1201 acactttctg ttcggacctc tgcagatgat tgtgaacact tcaggcggcc ctgagttccc
     1261 gaggagtgtg cgacgaccac atttgacctt ggaggctgtg gcgctgctcc gcgacaatgt
     1321 cactcctcgt gaaaatgaac tatggacctc actgggggac tcctggaccc gcccaggggt
     1381 ggagctgccc cctgaagaag ggtctccata cagtccggaa ttctacagcg gttgggaacc
     1441 tccggccact gacccgcagg gccgcccctg ggaggaccca gtggaaaaac agctacagca
     1501 cgagaagcgg cgcaggcagc aaagcgcccc ccaagtcgcg gtcaatggtc atcaagatcc
     1561 agaactggaa actgagtccc agctagaaga gaaagccaga aaatgggttc tgtgtaatta
     1621 tgacttccag gcccgaaatg gcagcgagct atctgtcaag caccgagatg tgttggaggt
     1681 cctggatgac aggcgcaaat ggtggaaggt tcgggaccat caaggacaag agggctatgt
     1741 accctataat atcctgacac cccaccctgg acctcaggtg cactgcagcc aaagctccgc
     1801 aataaaccta gagactagcc cacctcctcc cccacctgct gcagctccag cccccactca
     1861 ggtgcggccc cagtgggaca gttgcgacag tctaaacagt ttggatccca gcgacaagga
     1921 gaaattttcc cagatgcttt gtgtcaatga ggagctgcag gcgcgcctgg cgcagggccg
     1981 ttcgggtccc agccgggtaa ccccggggct tcgagccccg gagccccagc tcagcccacg
     2041 ctctgaggcc tcggtggtcc gtgcctggct gcagaccaag ggctttagct ccgggactgt
     2101 ggatgcgctt ggagtgctga ctggcgcaca gctgttctcg cttcaaaagg aagagttgcg
     2161 gtcggtgtgc ccggaagaag gggcgcgagt atatagccaa gtcactgtgc agcgggcgct
     2221 actggaggac agagaaaaag tatcagagct ggaggccgta atggagaaac aaaagaaaaa
     2281 agtggaaggc gagaccaaaa cagaagtcat ttgatcctgg ttcattcata aaaagtgatg
     2341 agatggtggg gttcccagcg ccccgaaaga caacagtcac cagactcctc ccccaacgtc
     2401 agtagcagta gatgccgtaa aggaccgccc accctgggtt ccccgcggtc ctggcgggcg
     2461 gactgcattg acagtgctga ccggaacctt tccagaggga ctgatgggaa tggggaaggg
     2521 aacagagcat ggacactact agaaaggcac gcccaagagg cgcgatgatg gccctgtgcg
     2581 ttgtgatgcg ctataaacag cctcctttta ggctatgtcc acctgctgtc cccccccaca
     2641 cacaccccct ctcttgccgg ccaccaagat gccaggaatc tagaagacat ccatattttc
     2701 tctccacaaa cctggagatt ccaacccagg cttcctctta agcaccaatc tatccttgct
     2761 ctaacactat ctacaatctc tctctggttc aaaatccttt cctgtcaact agcgtgaggc
     2821 ctgggatttt cctttcaaag gcagagggtg tctccttcca ccccccattt tgggtcaacc
     2881 cctccaatca caggcatttc cgcacttact gcttctgctg gttggagcag cttccatcaa
     2941 tgtggctcaa ctcacctaca ttccatggat gcctgtgcca gccactaagg attcagctat
     3001 gaagatcggg atgctatagg ctcttgggtc ttccagtccc cagaactttc tccctgccaa
     3061 gtcctgcaac ttgtctggtt tatttaggtg gctagtaaga gctggttttc tcattgagac
     3121 tagatacccc taaggttttt ttttttcctg ctgtggcact tccctttgca tccctaaaac
     3181 acttcaagag tcacaccagt gcagttggcc tctgctctcc aggcagttca gctcttacct
     3241 gagccaccag tggcacacct caaatccaag ctagaaaagc cagcctttgg gctgacagct
     3301 tcactatacc cactttgctc cagaacacta tccacaatag atctctttcc cacttcctgt
     3361 ctacctctca agcatgtctc ttggcttctc ccgacagatg ggataaaacc taaccccagc
     3421 atgaaagttg atatacatga ccactccagg ttcagggccc tcttcctccc ttttcaggac
     3481 cccaagcatt ggttcgtgct gttggctctg ctaggaatgt cctggccttt tggagtctaa
     3541 tcactgcctg tcgttcctta tgtcagggtt gggtggttag ttggttgatt ggttttgttg
     3601 gagatagtct ggatatagcc tcaaagtctc aattctgttt cagtttcctg catgctgaga
     3661 ttcctggcag atgccctcct gccttctttt ctaagaaact taaaaacaca agcagtttgc
     3721 ccaaactgtt tttgactctg cagtgagctc ccaggctcca ggctgcaggc tgccgtgcag
     3781 gcagggacca gctggcttgc tggaacacca gatgcctcta gctctctatg gtctggaatc
     3841 tgatcatttc tatctgctta tcctgacttc atcctttgtt gatcaccctg tccgtcactc
     3901 ctccaatctg tatcgatgtt cagacatagg gacctgttac aactcaagtc agatggcagt
     3961 ctgctggcca gacctcccac ctcagagctc aagtccttag tagagccaca tccctgcaca
     4021 aagccagcag cacttcaaca cttcctctgc tattcagccc caagtttctt cctgcacctt
     4081 agcatgccag gcctactcta ccctatgacc tttgcatctc atcactgaaa atgggcttcc
     4141 ttcagacata tggctcactc tgctaccttc tagttccacg tgtcatgtct tgggtctact
     4201 ttgactacca taaacaccat acatacacac cagatacata cccaacatac accataaaca
     4261 tcagccatgc cacgcaccac acaaaatgca caccacacac acaccgtcca cccctgacaa
     4321 cacccatcca cccacatcca cttcccttct ctttctccac agcactacag ctgaaatcca
     4381 tacactagtt acctctctcc tgcagaacct ggctcctggc ctaagctact cactcttggg
     4441 actccagtag gtaggacaga gcccagctgg tagtgtaggc agttgctcct gactataaga
     4501 atgaaggtac aatgaatcac aagactgcct cctactattc cagccaatgt ggccgtggag
     4561 gactgaggga actcaccatc acttattcat ttcccagaga agttacactt gtggagtttt
     4621 ctgtgatcca tcccacattt tcaatgtcag ccattaactc cactcctttc aggggaactg
     4681 agggcaaatc tgggcactcc agccccttat cacagcacca tgggcttcct tctgaccctt
     4741 cccacctcat ctgggatcct ttgctccagc tgctcactta gcaaggtgcc ctccctactc
     4801 ctgtgagcac gctccaacct tgcctccaac tgtacctacc ccatccaaat gggcttggtc
     4861 agcctgagtc aacaagcaga acaagtcact gagtggcaat gtcacgactt tatttatggt
     4921 gcctgtgctt tgtctcaaaa ataccttctc ctcctcccca gacaataggt ggggaggagg
     4981 cagcaaaaat agaacatccc tccctattgc acatggaccc tatatacagg cccacctggc
     5041 agaggccagt gggactcttg gcacattcct ggtccctgct ggggaggggg ggaggagtgc
     5101 tgggtagcat cacacgtgag gtgggaccct ggggcaacca ctctgcttct ggatacttat
     5161 ctttgcattt cttggtcctt gtttccttct tggtcccatc tctgatgctc agagcaacat
     5221 ctcagcaaca tctccctacc tggctcagcc tcccacctct atcctgacct cagagaaccc
     5281 cttggttcct ggggactctg tgctttcctc ccggttctga ggtcccgaga ggttatggct
     5341 tctcagcaac ttcccccaga gccttgtcac tcatgttcac gcgggggaaa gggtgcgtgt
     5401 gtcagaagca gcagtataaa tatggtgcgg g
//
LOCUS       NM_001437598            2910 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myeloid zinc finger 1 (Mzf1), transcript variant
            2, mRNA.
ACCESSION   NM_001437598
VERSION     NM_001437598.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2910)
  AUTHORS   Xing,F., Gu,H., Niu,Q., Fan,X., Wang,Z., Yuan,J., Li,Z., Xu,J.T.
            and Zhang,W.
  TITLE     MZF1 in the Dorsal Root Ganglia Contributes to the Development and
            Maintenance of Neuropathic Pain via Regulation of TRPV1
  JOURNAL   Neural Plast 2019, 2782417 (2019)
   PUBMED   31582966
  REMARK    GeneRIF: that MZF1 may contribute to neuropathic pain via
            regulation of TRPV1 expression in dorsal root ganglions
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2910)
  AUTHORS   Li,Z., Gu,X., Sun,L., Wu,S., Liang,L., Cao,J., Lutz,B.M.,
            Bekker,A., Zhang,W. and Tao,Y.X.
  TITLE     Dorsal root ganglion myeloid zinc finger protein 1 contributes to
            neuropathic pain after peripheral nerve trauma
  JOURNAL   Pain 156 (4), 711-721 (2015)
   PUBMED   25630025
  REMARK    GeneRIF: This study demonstrated that MZF1 participated in
            CCI-induced reductions in Kv1.2 mRNA and protein and total Kv
            current and the CCI-induced increase in neuronal excitability
            through MZF1-triggered Kv1.2
            Erratum:[Pain. 2022 Feb 1;163(2):e384. doi:
            10.1097/j.pain.0000000000002563. PMID: 35029603]
REFERENCE   3  (bases 1 to 2910)
  AUTHORS   Peterson,F.C., Hayes,P.L., Waltner,J.K., Heisner,A.K., Jensen,D.R.,
            Sander,T.L. and Volkman,B.F.
  TITLE     Structure of the SCAN domain from the tumor suppressor protein MZF1
  JOURNAL   J Mol Biol 363 (1), 137-147 (2006)
   PUBMED   16950398
  REMARK    Erratum:[J Mol Biol. 2007 Feb 9;366(1):346]
REFERENCE   4  (bases 1 to 2910)
  AUTHORS   Le Mee,S., Fromigue,O. and Marie,P.J.
  TITLE     Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human
            N-cadherin promoter in osteoblasts
  JOURNAL   Exp Cell Res 302 (1), 129-142 (2005)
   PUBMED   15541732
REFERENCE   5  (bases 1 to 2910)
  AUTHORS   Morris,J.F., Rauscher,F.J. 3rd, Davis,B., Klemsz,M., Xu,D.,
            Tenen,D. and Hromas,R.
  TITLE     The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in
            vitro
  JOURNAL   Blood 86 (10), 3640-3647 (1995)
   PUBMED   7579328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.2568867.1,
                                           SRR26360176.1307292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000001.1  82754747-82754923   c
            178-1168            JAXUCZ010000001.1  82752397-82753387   c
            1169-1239           JAXUCZ010000001.1  82751925-82751995   c
            1240-1360           JAXUCZ010000001.1  82751686-82751806   c
            1361-2910           JAXUCZ010000001.1  82743531-82745080   c
FEATURES             Location/Qualifiers
     source          1..2910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2910
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="myeloid zinc finger 1"
                     /db_xref="GeneID:361508"
                     /db_xref="RGD:1308391"
     exon            1..177
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            178..1168
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    982..984
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="upstream in-frame stop codon"
     CDS             1027..2793
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 98"
                     /codon_start=1
                     /product="myeloid zinc finger 1 isoform 2"
                     /protein_id="NP_001424527.1"
                     /db_xref="GeneID:361508"
                     /db_xref="RGD:1308391"
                     /translation="MEPSSFQPRPQVKLQTPEAGSETTPGATQELPLDLQMKEETELM
                     ENPELLESEPLSAAQEAAATLLPKVAQGHGIALDQTSPHSDTEPDVPPWSEDPMPLWH
                     EEVEGILSPGFTLQMDSITAEPDTVSPHLHVPWDLDMASLSGQMQSPTREGGFAHALV
                     LPSDPGSEQDPACEDPCPSVGPALVATRWHAPRDRSQGHPSTGTGVMRGGRCDVCGKV
                     FSQRSNLLRHQKIHTGERPFVCGECGRSFSRSSHLLRHQLTHTEERPFVCRDCGQGFV
                     RSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPAPPVRSLAGVPE
                     PPGPFPCSECCESFPRRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGE
                     RPFACAECGQSFRQRSNLTQHRRIHTGERPFACTECGKAFRQRPTLTQHLRVHTGEKP
                     FACPECGQRFSQRLKLTRHQRTHTGEKPYRCSECGLGFTQVSRLTEHQRIHTGERPFA
                     CPECGQSFRQHANLIQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQ
                     DCGRRFHQSTKLIQHQRIHSTE"
     misc_feature    1657..2736
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1657..2736
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1660..1722
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1660..1722
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1675..1677,1681..1683,1687..1689,1693..1698,
                     1705..1710,1717..1719,1759..1761,1765..1767,1777..1782,
                     1789..1794,1801..1803,1843..1845,1849..1851,1855..1857,
                     1861..1866,1873..1878,1885..1887)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1675..1677,1681..1683,1687..1689,1693..1698,
                     1705..1710,1717..1719,1759..1761,1765..1767,1777..1782,
                     1789..1794,1801..1803,1843..1845,1849..1851,1855..1857,
                     1861..1866,1873..1878,1885..1887)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1744..1806
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1744..1806
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1828..1890
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1828..1890
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1912..1974
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1912..1974
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2047..2109
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2047..2109
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2131..2193
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2131..2193
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2215..2277
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2215..2277
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2230..2232,2236..2238,2242..2244,2248..2253,
                     2260..2265,2272..2274,2314..2316,2320..2322,2332..2337,
                     2344..2349,2356..2358,2398..2400,2404..2406,2410..2412,
                     2416..2421,2428..2433,2440..2442)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2230..2232,2236..2238,2242..2244,2248..2253,
                     2260..2265,2272..2274,2314..2316,2320..2322,2332..2337,
                     2344..2349,2356..2358,2398..2400,2404..2406,2410..2412,
                     2416..2421,2428..2433,2440..2442)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2299..2361
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2299..2361
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2383..2445
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2383..2445
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2467..2529
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2467..2529
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2482..2484,2488..2490,2494..2496,2500..2505,
                     2512..2517,2524..2526,2566..2568,2572..2574,2584..2589,
                     2596..2601,2608..2610,2650..2652,2656..2658,2662..2664,
                     2668..2673,2680..2685,2692..2694)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2482..2484,2488..2490,2494..2496,2500..2505,
                     2512..2517,2524..2526,2566..2568,2572..2574,2584..2589,
                     2596..2601,2608..2610,2650..2652,2656..2658,2662..2664,
                     2668..2673,2680..2685,2692..2694)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2551..2613
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2551..2613
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2635..2697
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2635..2697
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2719..2781
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2719..2781
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1169..1239
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1360
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2910
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgggggg catgcgcggt gtggaaggcg gtgctaccat ctgttgcccc ccgagaggat
       61 tgtgcacgtc gacggggccc tgacgcctgg attcgagacg gggagtgtgg gaagagacgg
      121 ccaggagtgc gacctgatta ttgcgaccag cgcaatccct tggggacggg aagaagggga
      181 cagacactgg cctcaaagac ctgatctggt tctcctgatg aaacccattg tgccagactc
      241 ctcaggccgt gcacccccag aaaatgagcc tgctgtggtg aagctggagg actctgacaa
      301 ctacgataag agagaagata cactgtggga cccaggccct gaagctgcac gtctacgctt
      361 ccggtgcttt cggtatgagg aggcaatagg tcctcaggaa gccctggctc agctccgaga
      421 actgtgtcac cagtggctac gtccagaggt acattccaag gaacagatcc tggaactttt
      481 ggtgctggag cagttcctag gtgcactgcc ttctgagatc caggcccgtg tgcaagagca
      541 gtggccaggc agccctgaag aggctgctgc cttggttgac agacttcgat gggagcttga
      601 tggacctcgg aaatgggtga gtcggtagct gaatagaagg tcagggctgg agcattgtca
      661 cgttttacct cactctaaga gtgccatgcc tagccagaca tgttccttgg tcatacagaa
      721 gtgtctactt ataatggatc ctttgtgaag ctgctcagga caagagccca tagctatatt
      781 acctgtcatc ccaaagctag atgaaacaca atgggtacca tgcaaccccc tgtaccagca
      841 aatagtccct ttgctcaggg tcaaaagagg ggaatgggag gtttaggaat ttgaaggacc
      901 taatcagtct gctttggagt tggtgcccat agagcatggg ttgtgcccag ccccactctc
      961 tccctggtcc gtgcatctcc ctaggtcacg gtccaggtac agggcaagga ggtcctatca
     1021 gagaagatgg aaccttccag cttccagcct agacctcaag tcaagcttca gactccagag
     1081 gctgggtctg agactacccc aggggccacg caggaattgc cgctggacct acaaatgaaa
     1141 gaggagacag agttgatgga gaatccagag ctcctggagt ctgagcctct ttctgctgct
     1201 caagaggctg cagccactct cctacctaag gtggcccagg gccatgggat agcactggac
     1261 cagacctctc ctcacagcga cactgaacct gatgtgcccc catggagcga ggaccctatg
     1321 cccctgtggc atgaggaagt agaaggcatc ttgtcgccag ggttcacgct gcagatggac
     1381 agcatcacag cagagccaga tacggtgagc ccccacctcc atgtcccctg ggatctggac
     1441 atggctagcc tctctggaca gatgcagtcc cctaccagag aaggtggctt tgcccatgcc
     1501 ctcgtactcc ccagcgatcc aggaagtgaa caggaccctg cctgtgagga tccctgcccc
     1561 agtgtgggcc cagcactggt ggcgactcgc tggcatgccc caagggaccg gagccagggc
     1621 caccctagca cagggactgg agtgatgcga ggcggccgct gcgacgtgtg tggcaaggta
     1681 ttcagccagc gaagcaatct gctgcggcac cagaagatcc acacaggcga gagaccgttc
     1741 gtgtgtggcg agtgtggccg aagtttcagc cgcagctctc acctgctgcg ccaccaactc
     1801 acgcatactg aggaacggcc tttcgtgtgc cgcgactgtg gccaaggctt cgtgcgcagc
     1861 gcccgcctgg aggagcatcg gcgcgtgcac acgggcgagc agccgttccg ctgcgcagag
     1921 tgcggccaga gctttcggca gcgctccaac ctactgcagc accagcgcat ccacggtgac
     1981 ccgccaggtc cggcgccgcc cgtccggtcc ctcgctggag tgcccgagcc tccgggcccc
     2041 ttcccttgca gcgagtgctg cgagagcttc ccacgacgcg cagtactgct cgagcaccaa
     2101 gcggtgcaca ccggagacaa gtccttcgga tgcgtggagt gcggcgagcg cttcggccgc
     2161 cgctcggtgc tgctgcagca tcggcgcgtg catagcggcg aacgaccttt cgcatgtgcc
     2221 gagtgcggtc aaagcttccg gcagcgctcc aacctcaccc agcaccggcg catccacacc
     2281 ggcgagcggc ccttcgcctg cacagaatgt ggcaaggcct tccgccagcg gcccactctc
     2341 acgcagcacc tgcgtgtgca caccggtgag aagcccttcg cctgccccga gtgcggccag
     2401 cgcttcagcc agcgactcaa gctcacacgc caccaaagga cccatacggg cgagaagccc
     2461 taccgctgca gtgaatgcgg cctcggtttc acgcaggtgt ctcggctcac cgagcaccag
     2521 cgcatccaca caggtgagcg gcctttcgcc tgtcccgaat gtggccagag cttccggcag
     2581 cacgccaacc tcatccagca ccggcgcatc catacaggcg agcggcccta cgcgtgtccc
     2641 gagtgtggca aggccttccg ccagcggccc acgctcacgc agcacctgcg cacccaccgg
     2701 cgcgaaaagc ccttcgcctg ccaggactgt ggccgccgct ttcaccagag caccaagctc
     2761 atccaacatc aacgcatcca cagcactgag tagctgtaca gcactgagta ggtcaaaaca
     2821 cctcattagg ttgttgtgag gctgccatct tccaacaggc ccaagtagag ccttcagtag
     2881 gtgctcaata aatagataat gcttccccaa
//
LOCUS       NM_001437553            5083 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 5, mRNA.
ACCESSION   NM_001437553 XM_063287198
VERSION     NM_001437553.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5083)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.6226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3642           JAXUCZ010000001.1  254862695-254862762
            3643-4360           JAXUCZ010000001.1  254863590-254864307
            4361-4498           JAXUCZ010000001.1  254865878-254866015
            4499-4559           JAXUCZ010000001.1  254866114-254866174
            4560-4681           JAXUCZ010000001.1  254866293-254866414
            4682-4833           JAXUCZ010000001.1  254866843-254866994
            4834-5083           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5083
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4937
                     /gene="Pprc1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 5"
                     /protein_id="NP_001424482.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGIDTPQEKKPLDRLHAPELANVA
                     GLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGVR
                     GPSPVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAAP
                     PLPCTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQR
                     SMRCYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSLS
                     PPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRSYRS
                     NDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGD
                     NYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDP
                     APVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4109
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4109
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4563..4835
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4563..4835
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3642
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..4360
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4498
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4559
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4560..4681
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4682..4833
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..5083
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact caggcattga cactccccag gagaagaaac
     3601 ccctagaccg gttacacgcc ccagaactgg ccaacgtggc agggctcacc ccgccagcta
     3661 cccctcccca ccagttatgg aaacccctgg ctgctgtctc actgttggcc aaagccaaat
     3721 ctcctaaatc tactgcccaa gagggaaccc tgaagcctga aggaattaca gaggccaaac
     3781 ctccagctgc agcctgcctc caagaagggg tccgtggccc tagtccagtc catgtgggct
     3841 ctggggacca tgactattgt gtccgaagca ggacaccccc aaaaaagatg cctgccctag
     3901 tcatttcaga gatgggctct cgatggaatg tcaagcgcca tcaggacatc actatcaaac
     3961 ctgtcttgtc attgggctca gctgcccccc cactcccatg cacaaccact tcccaggaac
     4021 cgcttgatca caggactagc agtgagcagg cagatccgtc agcgccttgt tttgccccat
     4081 ccaccttgct gtctcctgag gcctcaccct gccggaatga aatgaacact aggactccct
     4141 ctgagccccc agacaagcag cggtcaatgc gctgttaccg aaaagcctgc agatcagcca
     4201 gccccccaag tcggggctgg caaggccgcc gtggccgtag cagccgttct gtcagctctg
     4261 ggtccagccg gaccagtgaa gcatcctcat cctcatcggt gtcttcctca tcccggtccc
     4321 ggtccaggtc cctctccccc ccaaacaaga ggtggcgaag gtccagctgc agttcctctg
     4381 gacggtccag aagatgttcc tcctcttcct cttcttcctc ctcctcatct tcatcatcca
     4441 gttccagaag ccggtctccc tctgtgtccc cttgcaggag aagtgaccgg aggcggcgct
     4501 cttaccgttc aaatgaccat taccaaaggc agagagtact gcagaaggag cgtgcaatag
     4561 aagagagaag ggtggtcttc attgggaaaa tacctggccg catgactcgg tcggagctga
     4621 agcagaggtt ctctgttttt ggagagattg aggagtgtac cattcatttt cgtgtccaag
     4681 gtgacaacta tggtttcgtc acttaccggt atgctgaaga ggcatttgca gccattgaga
     4741 gtggccacaa gttgcggcag gcagacgagc agccctttga tctctgcttt gggggccgaa
     4801 ggcagttctg caagaggagt tactctgatc ttgactccaa tcgggaagac tttgatcctg
     4861 ctcctgtcaa gagcaaattc gattctcttg actttgatac tttgttgaaa caggcccaga
     4921 agaacctaag gaggtaaccc tgggctttcc tcccccatcc attttctctg gaggtgtcca
     4981 acctctcaac cccctcccct actctagggg agagagctgc tagtgtggaa agacttttat
     5041 aaggaaatga aaaaaagtta aataaaaata tgttaaatcg gga
//
LOCUS       NM_001437568            1381 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), transcript
            variant 3, mRNA.
ACCESSION   NM_001437568 XM_017589043
VERSION     NM_001437568.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1381)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1381)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1381)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1381)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1381)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_017589043.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5951.1,
                                           SRR26360186.591628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000001.1  256370664-256370776 c
            114-289             JAXUCZ010000001.1  256369932-256370107 c
            290-385             JAXUCZ010000001.1  256363461-256363556 c
            386-454             JAXUCZ010000001.1  256358861-256358929 c
            455-622             JAXUCZ010000001.1  256351463-256351630 c
            623-746             JAXUCZ010000001.1  256350493-256350616 c
            747-918             JAXUCZ010000001.1  256348306-256348477 c
            919-1038            JAXUCZ010000001.1  256344882-256345001 c
            1039-1111           JAXUCZ010000001.1  256342471-256342543 c
            1112-1381           JAXUCZ010000001.1  256336916-256337185 c
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1381
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..113
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..289
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    130..132
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="upstream in-frame stop codon"
     CDS             136..1269
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 1; CST complex subunit STN1; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide-binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1 isoform 1"
                     /protein_id="NP_001424497.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNSKDTLDLAGLTALL
                     SEKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVF
                     KNALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNHVEKGCHLM
                     HVLNCVLLNLRWDLNKAVLQQVLELLEDQSDIVSTGDHYYTAF"
     misc_feature    328..630
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    328..630
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    order(328..330,556..558,562..564,568..570,622..624)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(328..330,556..558,562..564,568..570,622..624)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(343..351,376..387,391..393,409..417,421..423,
                     553..555,574..582,601..609)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(343..351,376..387,391..393,409..417,421..423,
                     553..555,574..582,601..609)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    769..1266
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    769..1266
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     exon            290..385
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..454
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..622
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..746
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..918
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1038
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1111
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1381
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcgcaa ccggaactat ttcggcaatc ttggccaact gctcctgctc cgggagaggc
       61 tgtaaaccgc tctgattctg cctccttttc ctttcctccg ctcttcccag aagagtcttg
      121 gctcagggtt agcagatgcc agaaccttgc cttttgatgc agtgcgaatc cagtccaaaa
      181 gaagaggaga tcccgtccct cttttggggt ctggatcccg tgtttctagc ctttgcaaaa
      241 ctctacatca aggacatcct ggagatgaag gagtcccaac aagtgccagg catgtatttt
      301 tacaatggac atccaataag acgggtggat atcatgggag ctgtcatcag tgtgaaagag
      361 agagagactt tctacagcta tggagtggat gacgccacag gggttataaa ctgtgtgtgc
      421 tggaaaaggc caagcaatgc cgagtcttca tcagacccag ctattctgag cacttcgaga
      481 gaactcagca tgacctcaca gcttaagaaa ctgcaggaga ccattgagca gaaaaccaag
      541 atcgggattg gggatatcat ccgagtccga ggctacgtgc gtatgttccg agaagagcga
      601 gagatctgtg ccaccattta ttataaggtg gacgatccag tgtggaacat gcaaattgca
      661 aggatgcttg agctgccaga gctctacaag aaggtgtatg accagccctt ccggaaccca
      721 gccctaaagg aggaagaggc actaaacagt aaagacactt tggatctcgc tggcctcacg
      781 gctttgttga gtgagaaagt taaagaattt ctccaggaga agaaagtgca aagcttctac
      841 cagaaggagc tggaaatggt ggagcccttg cagtctctgg ccagtcagcc cgtgacccac
      901 agcacgtgct cggaccaagt ggagttaaag aacgacgccg cttctgacat acacagtgtg
      961 tttaagaatg ctctgcacct gcttcaggaa aaggggttcg tgttccagag agacggtggc
     1021 tccgataagc tgtactatgt taccagtaag gacaaagacc tgcaccagaa gatctaccag
     1081 atcattaagg aagactgtca gaaaccaaat catgtggaga agggctgcca cttgatgcac
     1141 gtcctgaact gcgtgctcct caacctccgc tgggacctga acaaggctgt gctgcagcag
     1201 gtgctggagc tcctggagga ccagagcgac attgtgagta ctggagacca ctactacacg
     1261 gccttctgag cagagccacg gagaggcagc aggcagcttt accccaggtt ctgctcccag
     1321 gcgttgtaga gacttatttg tgtataatcc cctaataaag tctgatacag ccacaggaaa
     1381 a
//
LOCUS       NM_001437575            5498 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 1, mRNA.
ACCESSION   NM_001437575 XM_039080825
VERSION     NM_001437575.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5498)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5498)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5498)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5498)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5498)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5498)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5498)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5498)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5498)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5498)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_039080825.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1704.1,
                                           SRR26643295.2508.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345329,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-170             JAXUCZ010000001.1  130365401-130365453 c
            171-364             JAXUCZ010000001.1  130337632-130337825 c
            365-568             JAXUCZ010000001.1  130317243-130317446 c
            569-706             JAXUCZ010000001.1  130292969-130293106 c
            707-926             JAXUCZ010000001.1  130290825-130291044 c
            927-986             JAXUCZ010000001.1  130289823-130289882 c
            987-1174            JAXUCZ010000001.1  130277028-130277215 c
            1175-1198           JAXUCZ010000001.1  130271166-130271189 c
            1199-1325           JAXUCZ010000001.1  130267560-130267686 c
            1326-1452           JAXUCZ010000001.1  130263566-130263692 c
            1453-5498           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5498
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..170
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..364
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    299..301
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             311..1822
                     /gene="Mef2a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 1"
                     /protein_id="NP_001424504.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPD
                     TSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPG
                     SSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPN
                     GAGNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVV
                     IPPSSKGMMPPLSEEEELELNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPT
                     AYNTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNL
                     SINTNQNINIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSP
                     VDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    599..772
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    599..772
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    <695..>1450
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <695..>1450
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            365..568
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            569..706
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            707..926
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            927..986
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1174
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1198
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1325
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1452
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..5498
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcggaa
      121 ttgcatcttg tggaaaagga acaaagaaga actttctgca aggataaaat atttttaaga
      181 caatttcagc ggcagccttg gactggaagg ttaaataata ggaactgtgt acgatgcatt
      241 aggatattga agaaaattag cttctgaatt aattatttgg aatataagga agaaaaggtg
      301 acttttgaaa atggggcgaa agaaaataca aattacacgc ataatggatg agaggaaccg
      361 acaggtgact tttacaaagc gaaagttcgg attgatgaag aaagcctatg aactcagtgt
      421 gctctgtgac tgtgagatag cactcatcat cttcaacagc tctaacaagt tgtttcagta
      481 cgccagcact gacatggaca aagtccttct caagtacacc gagtacaacg agcctcatga
      541 aagcaggacg aactcggata ttgtggaggc tctgaacaag aaggaacaca gaggctgcga
      601 cagcccagac cctgatactt catatgtgct aactccacat acagaagaaa aatataaaaa
      661 aattaatgag gaatttgata atatgatgcg gaatcataaa atcgcacctg gcttgccgcc
      721 tcagaacttc tcaatgtctg tcacagtccc tgtgaccagc cctaatgctt tgtcgtacac
      781 taacccaggg agttcactcg tgtcaccgtc tttggcagcc agctcaacat tagcagagtc
      841 cagcatgctg tctccacccc cagccacgct acatagaaat gtgtctccag gagctccgca
      901 gagaccacca agcactggca gtgcaggtgg gatgttgagc actacagacc tcacggtacc
      961 aaatggagct ggaaatagtc ctgtggggaa tggatttgta aactcaaggg cctctccaaa
     1021 tttgattgga aatactggtg cgaatagtgt aggcaaagtc atgcctacaa agtccccccc
     1081 gccaccaggt gggggcagtg ttggaatgaa cagtcggaaa ccagatctac gggttgtcat
     1141 tcccccttca agcaagggca tgatgccccc actttcggag gaagaggagt tggagctgaa
     1201 tgcccaaagg ataagtagtt ctcaagccac acaacctctt gccacgcccg tggtgtctgt
     1261 gacaactcca agcttgcctc cgcagggact agtgtactcg gccatgccga cagcctacaa
     1321 cactgattac tcattgacca gcgctgacct gtccgccctg caaggcttta cttcccctgg
     1381 aatgctgtct ctggggcagg cttcagcctg gcagcagcac catctaggac aagcggccct
     1441 cagctctcta gtggctggag ggcagttatc tcagggttca aatttgtcca ttaacaccaa
     1501 ccagaacatc aacattaagt cagagccaat ttcacctccc cgtgatagaa tgaccccatc
     1561 aggcttccag cagcagcagc agcagcagcc acagcagcaa ccaccgccac aacctccaca
     1621 gccccagccc caaccccggc aggaaatggg gcgctcccct gtggacagtc tgagcagctc
     1681 tagcagctcc tacgatggca gtgaccggga ggatccacgg ggcgacttcc attctccaat
     1741 tgtgcttggc cgacctccaa atgctgagga cagagaaagc ccctctgtaa aacgcatgag
     1801 gatggacaca tgggtgacct aaggcttcct ggttcatgtc tgttctttgt gttactgcag
     1861 tgaactgccc tacatatctt aaattggtga ataaggacat gagttcaata tatttatatg
     1921 tacatgcata catatatatc cctttacata tatatgtatg tcggtgtgag tgtgtgtatg
     1981 tgtgggtgtg tgttgcatac acagaatcag gcacttactg cgactccttg taggtatgca
     2041 gatgtgtgca cacggcacac agagcacctt gtagagacag accagcctgg cacttccttg
     2101 gactacttgt ctcctaagat aaagtttttg cagagaaacg tgtacccata tataattctt
     2161 ccacattagc ctgcagaaac ctaggggccc ctatttgttt tatttacctg tgcggtgact
     2221 gtagttactt caaaaaaaaa aaaaattgct ttgtagaaca gagcagtaga aaagcaggaa
     2281 ccaagaaagc aatactgtac ataaagtcat ttatattaat aacccaacct ggcatgggtc
     2341 tattgcagag gggtgcatgg gcaagggctg tctatattaa acagacacag taaacaaaga
     2401 gccccacaca taactgtttt gcacgtgcaa aaaaatgtat tgggtcaaag aagtgatttt
     2461 tagctattaa aaagagagaa tagaaaacac gcatgaaata ttcagaaata ctagcctaga
     2521 aatatagagc attaacaaaa taaaattaat atattaagtt ataattggaa tatgtcagaa
     2581 gtttctttta cattcatatc tttaaaaatt aaagaaactg attttaggtc atgtatattt
     2641 tatatgaaag aaaacaccct taatgaattg atgactatat ataaaattat atccactact
     2701 tttgaacaca ttctgctgaa ttatttatat aagccaaagc tgtatgttgt aacttttttt
     2761 tttaaagaat agctttatct tgttttaact ttttagtttt attttaagag ggaagaaaaa
     2821 aacaaaaata tcttgcaagc agaaccttgg aaaaaaaaaa gccatgaaca ttattattct
     2881 atatgtaaat taaaagtcga gccaaactct ttgtgtatat agcatcttaa atatattacc
     2941 acctttgatg taagtaccta tgtattgtat ggtcaccaga ttaaaaagta tatttttgtg
     3001 gattgccacc aatttggggg gaaaggcgaa gtccttaagt agagtattca ctgtttaata
     3061 tttactattt tgttaaatat actgtacttt ggattttaat tattagccca gtttttcaga
     3121 ggattgtgta aaggggtttc ccctcactgg tggtgaatgt gtgatgttct gttgtaatct
     3181 ttgtgctgta tggggtgagc atcattatat attttatatg tgtacataaa tagcaaagtg
     3241 gcaaaaaaat tggtgttaag ttcatcctgc ataaatataa aatgtgttgt aacagatttt
     3301 ataaggcatt atttaaaact tgccttttgt gagggaaaaa aaaaaacagt agaaagatga
     3361 cctaatttaa ctaatattag agaaaatggc tgagtagtag atgagcacaa aggttttata
     3421 agtggtaaat aattaggaaa atatttgtag gggaagggat cttttctcct tgactctaaa
     3481 gatagaatga tgcagctggt tacaaaatcc aggagggctt tagcgtcccg tgcgtgggaa
     3541 ggcacgggcg tgcagggagc agctctccta tggtgcagat ccccgacaca attcttgctg
     3601 tcctgacgga aactggtgcc accctcagct tggattttga acaaggcctt actcttacag
     3661 ggagacagct cgttggtgat ggcaagttca tccgtttact gggcttgtgc catgaacaaa
     3721 attcaaagtc ctgtatatct tttatcctag atttttaaat actccttttc ctgaaaaaac
     3781 ttaaagagtt taaaaatggc tgctatttta tactgaacaa tgttgagcag ctacctgcag
     3841 tttttactta cattttgctt ttcccctcga ttccctaaat tatgctcctt ttgatgtctc
     3901 ctcatctgct gtcccgacag ctcatcagcc aggtttcctg cctggccgca cacaggtatt
     3961 cggtccatgc accgtggtga gcacaggctg tgcactggag agcctcactg acagtctggg
     4021 tagcacatgt tagtggaagc caaggaagtg gggacggtgt ctcatctcct ctgtggtctc
     4081 agcacttggc tcttcctcag agaaggttag gttttcttcc tcaagtgtac tgagttgact
     4141 tacaggcacg ttcctcataa ggtcacagtc tcccaacact gactttccaa gatacccctt
     4201 accactttgt aaaccattta tagctttgaa agtattaagt gaccctttca ttattattta
     4261 tgcatgttca tgaacttctg ctgtatattg ggataggagt taacacattc acatttactg
     4321 tctattttct tgtgtgcctt atgagatggc ttctctgact gtatctcaat agtctttcta
     4381 tgcaggttta taatcagtac aactactgtt ttctaaagga atattacaca cggctcggag
     4441 tttgtactta aattacactg accaagtcac aatgtattcc gttttcagga actgaatatc
     4501 tgactgttaa tcttttccca tatgcccagt gtgatctgga gcatatgggt ctgacatcct
     4561 tcacccagat gctcatgtgt gaacacatcc acatccacag ctctcagtgg aagccagcct
     4621 agagtaggga ggacactgac ggtgttgctt taaactgact tttcttaccc tttgagactc
     4681 atgtgttttg tataagacac catcacaaga aagttttctc ccttcagata acatatttta
     4741 ttattaaaaa gaaaaacaaa aaaagctttt aagttgcact ggacgtgggc cgttccttcg
     4801 gaactctttg gatctacact gagagtgagt gtcgccgctc tgtgaacaca ggtggtccca
     4861 gtcaaaactc catcctttga gccctaatta catccattgt gttacaaaac taaatcaggg
     4921 gtttgttcta aaagaacaat acatgtctca ccatttcctt tcaactgtaa agacgactga
     4981 taatgtatta acataatttc tgtattaacc atcatgcgca caagaaatac atagtaaata
     5041 cggaacctga aaactcctgc atcggatcat aaaagctaga tgattagaat gtgaaaagaa
     5101 ctttacagat gtaaaacttt tatttctctg tagaaacttt cttcactttg ctgtgcaaga
     5161 agacactgct ttgctatatt taaaatggct tttttaaaaa gagatttatg tatttggtaa
     5221 atgtttgtag tcaacagttc acacaaagaa gctgtacacg gtttgatcat gtaaaaccgt
     5281 ttggcggcac aagctggact ttgttgccat ccttgagatg aaccttttaa gaaaaataag
     5341 ttaatctcaa tttttccctg aatgtgttgt tttttcttca ttatacaata aatattatag
     5401 tgaagttttt atcaaatggt taagacaatg ctagaggttg ttgtaagcta tttgtctcct
     5461 gcactcactc cagtaaagat ggcctggctt tgaccata
//
LOCUS       NM_001437593            5459 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 4, mRNA.
ACCESSION   NM_001437593 XM_008758941
VERSION     NM_001437593.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5459)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5459)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 5459)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 5459)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 5459)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_008758941.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.806.1, SRR26643295.962.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000001.1  78402016-78402166   c
            152-205             JAXUCZ010000001.1  78401477-78401530   c
            206-246             JAXUCZ010000001.1  78398316-78398356   c
            247-305             JAXUCZ010000001.1  78398010-78398068   c
            306-467             JAXUCZ010000001.1  78397058-78397219   c
            468-617             JAXUCZ010000001.1  78396669-78396818   c
            618-700             JAXUCZ010000001.1  78396228-78396310   c
            701-965             JAXUCZ010000001.1  78395632-78395896   c
            966-1092            JAXUCZ010000001.1  78395199-78395325   c
            1093-1181           JAXUCZ010000001.1  78394918-78395006   c
            1182-1256           JAXUCZ010000001.1  78394740-78394814   c
            1257-1405           JAXUCZ010000001.1  78394489-78394637   c
            1406-1547           JAXUCZ010000001.1  78392927-78393068   c
            1548-1576           JAXUCZ010000001.1  78392786-78392814   c
            1577-1706           JAXUCZ010000001.1  78389932-78390061   c
            1707-1838           JAXUCZ010000001.1  78389705-78389836   c
            1839-1947           JAXUCZ010000001.1  78389331-78389439   c
            1948-2122           JAXUCZ010000001.1  78389017-78389191   c
            2123-2255           JAXUCZ010000001.1  78388632-78388764   c
            2256-5459           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..5459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5459
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..151
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Eps8l1"
                     /note="upstream in-frame stop codon"
     exon            152..205
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2342
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001424522.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     misc_feature    282..674
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    282..674
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    order(303..305,540..542,600..602)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(303..305,540..542,600..602)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(498..515,561..563,630..632,642..644)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(498..515,561..563,630..632,642..644)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    1632..1790
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    1632..1790
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    order(1632..1649,1653..1655,1662..1664,1671..1679,
                     1698..1715,1719..1745,1758..1769,1779..1790)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1632..1649,1653..1655,1662..1664,1671..1679,
                     1698..1715,1719..1745,1758..1769,1779..1790)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1653..1655,1665..1673,1722..1730,1734..1736,
                     1761..1766,1770..1781)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1653..1655,1665..1673,1722..1730,1734..1736,
                     1761..1766,1770..1781)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    2055..2252
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     misc_feature    2055..2252
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     exon            206..246
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..305
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..467
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..617
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..700
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..965
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1092
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1181
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1256
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1405
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1547
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1576
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1706
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1838
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1947
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2122
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2255
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..5459
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagcc agcaggcagg tgagaaggcc aggcctagtg tgagtgagga gagctgagtt
       61 gtagggtctt ggatctgaga cacaaggtat cctctggacc ccggatctga acaaggagag
      121 ctgatctaga ttcttggatc tgagagataa ggaacctcca agcggacaga gcacctcttc
      181 tggccaccat gagcaccacc acagggcctg aagctgcacc caaaccaagt gcaaagtcta
      241 tctatgagca gagaaaacgt tactccactg tggttatggc tgatgtgtcc cagtatcatg
      301 tcaatcacct ggtcaccttc tgcttggggg aggaagatgg cgtgcacact gtggaagatg
      361 cttccagaaa gctggcagtc atggacagcc aggggcgtgt ctgggcacag gagatgctac
      421 tgagagtgtc acctggtcat gtcactctgc ttgatccagt ctctaaggag gaactagagt
      481 catatcctct cgacgccatc gtacgctgcg acgcggtgat gccccgagga cggagccgct
      541 cgttgctgct cctggtgtgc caagagccag agcgtgcaca gccagatgtc catttcttcc
      601 agggcctgct cctcggggcg gagctgatcc gtgaggacat ccaaggggct ctgcagaact
      661 accgctccgg acgtggggaa cgcagggcgg cagcactcag ggctacgcag gaggagctgc
      721 gacgcggtgc ctctccagca gcggagaccc cgcccttaca gcgtcgccct tctgtccgcg
      781 cggtgatcaa cacggtggaa ccatccgcgg tgcgcgggcg accccaagtg gagccaattc
      841 cagagactga ggaagcgagg aaacccgacc cagcgcgcac gacgactagg agctctgatc
      901 ctacctcccc agacctgggc ccaaggggtc ctgagctggc cggtctgcag gcggagcggg
      961 atgtggatat cctgaaccat gtgtttgacg acgtggagag ttttgtatcc agactgcaaa
     1021 agtcagcaga ggctacccgg gttttggagc accgtgagcg cggccgcagg acacgacgcc
     1081 gagctgctgg agagggcctg ctgaccctaa gggccaagcc acccacagag gctgaataca
     1141 ctgatgtgct tcagaaaatc aaatacgcct tcagtctgct ggcccggttg cggggcaaca
     1201 tcgccaaccc ctcctctcca gagctgttac actttctgtt cggacctctg cagatgattg
     1261 tgaacacttc aggcggccct gagttcccga ggagtgtgcg acgaccacat ttgaccttgg
     1321 aggctgtggc gctgctccgc gacaatgtca ctcctcgtga aaatgaacta tggacctcac
     1381 tgggggactc ctggacccgc ccaggggtgg agctgccccc tgaagaaggg tctccataca
     1441 gtccggaatt ctacagcggt tgggaacctc cggccactga cccgcagggc cgcccctggg
     1501 aggacccagt ggaaaaacag ctacagcacg agaagcggcg caggcagcaa agcgcccccc
     1561 aagtcgcggt caatggtcat caagatccag aactggaaac tgagtcccag ctagaagaga
     1621 aagccagaaa atgggttctg tgtaattatg acttccaggc ccgaaatggc agcgagctat
     1681 ctgtcaagca ccgagatgtg ttggaggtcc tggatgacag gcgcaaatgg tggaaggttc
     1741 gggaccatca aggacaagag ggctatgtac cctataatat cctgacaccc caccctggac
     1801 ctcaggtgca ctgcagccaa agctccgcaa taaacctaga gactagccca cctcctcccc
     1861 cacctgctgc agctccagcc cccactcagg tgcggcccca gtgggacagt tgcgacagtc
     1921 taaacagttt ggatcccagc gacaaggaga aattttccca gatgctttgt gtcaatgagg
     1981 agctgcaggc gcgcctggcg cagggccgtt cgggtcccag ccgggtaacc ccggggcttc
     2041 gagccccgga gccccagctc agcccacgct ctgaggcctc ggtggtccgt gcctggctgc
     2101 agaccaaggg ctttagctcc gggactgtgg atgcgcttgg agtgctgact ggcgcacagc
     2161 tgttctcgct tcaaaaggaa gagttgcggt cggtgtgccc ggaagaaggg gcgcgagtat
     2221 atagccaagt cactgtgcag cgggcgctac tggaggacag agaaaaagta tcagagctgg
     2281 aggccgtaat ggagaaacaa aagaaaaaag tggaaggcga gaccaaaaca gaagtcattt
     2341 gatcctggtt cattcataaa aagtgatgag atggtggggt tcccagcgcc ccgaaagaca
     2401 acagtcacca gactcctccc ccaacgtcag tagcagtaga tgccgtaaag gaccgcccac
     2461 cctgggttcc ccgcggtcct ggcgggcgga ctgcattgac agtgctgacc ggaacctttc
     2521 cagagggact gatgggaatg gggaagggaa cagagcatgg acactactag aaaggcacgc
     2581 ccaagaggcg cgatgatggc cctgtgcgtt gtgatgcgct ataaacagcc tccttttagg
     2641 ctatgtccac ctgctgtccc cccccacaca caccccctct cttgccggcc accaagatgc
     2701 caggaatcta gaagacatcc atattttctc tccacaaacc tggagattcc aacccaggct
     2761 tcctcttaag caccaatcta tccttgctct aacactatct acaatctctc tctggttcaa
     2821 aatcctttcc tgtcaactag cgtgaggcct gggattttcc tttcaaaggc agagggtgtc
     2881 tccttccacc ccccattttg ggtcaacccc tccaatcaca ggcatttccg cacttactgc
     2941 ttctgctggt tggagcagct tccatcaatg tggctcaact cacctacatt ccatggatgc
     3001 ctgtgccagc cactaaggat tcagctatga agatcgggat gctataggct cttgggtctt
     3061 ccagtcccca gaactttctc cctgccaagt cctgcaactt gtctggttta tttaggtggc
     3121 tagtaagagc tggttttctc attgagacta gataccccta aggttttttt ttttcctgct
     3181 gtggcacttc cctttgcatc cctaaaacac ttcaagagtc acaccagtgc agttggcctc
     3241 tgctctccag gcagttcagc tcttacctga gccaccagtg gcacacctca aatccaagct
     3301 agaaaagcca gcctttgggc tgacagcttc actataccca ctttgctcca gaacactatc
     3361 cacaatagat ctctttccca cttcctgtct acctctcaag catgtctctt ggcttctccc
     3421 gacagatggg ataaaaccta accccagcat gaaagttgat atacatgacc actccaggtt
     3481 cagggccctc ttcctccctt ttcaggaccc caagcattgg ttcgtgctgt tggctctgct
     3541 aggaatgtcc tggccttttg gagtctaatc actgcctgtc gttccttatg tcagggttgg
     3601 gtggttagtt ggttgattgg ttttgttgga gatagtctgg atatagcctc aaagtctcaa
     3661 ttctgtttca gtttcctgca tgctgagatt cctggcagat gccctcctgc cttcttttct
     3721 aagaaactta aaaacacaag cagtttgccc aaactgtttt tgactctgca gtgagctccc
     3781 aggctccagg ctgcaggctg ccgtgcaggc agggaccagc tggcttgctg gaacaccaga
     3841 tgcctctagc tctctatggt ctggaatctg atcatttcta tctgcttatc ctgacttcat
     3901 cctttgttga tcaccctgtc cgtcactcct ccaatctgta tcgatgttca gacataggga
     3961 cctgttacaa ctcaagtcag atggcagtct gctggccaga cctcccacct cagagctcaa
     4021 gtccttagta gagccacatc cctgcacaaa gccagcagca cttcaacact tcctctgcta
     4081 ttcagcccca agtttcttcc tgcaccttag catgccaggc ctactctacc ctatgacctt
     4141 tgcatctcat cactgaaaat gggcttcctt cagacatatg gctcactctg ctaccttcta
     4201 gttccacgtg tcatgtcttg ggtctacttt gactaccata aacaccatac atacacacca
     4261 gatacatacc caacatacac cataaacatc agccatgcca cgcaccacac aaaatgcaca
     4321 ccacacacac accgtccacc cctgacaaca cccatccacc cacatccact tcccttctct
     4381 ttctccacag cactacagct gaaatccata cactagttac ctctctcctg cagaacctgg
     4441 ctcctggcct aagctactca ctcttgggac tccagtaggt aggacagagc ccagctggta
     4501 gtgtaggcag ttgctcctga ctataagaat gaaggtacaa tgaatcacaa gactgcctcc
     4561 tactattcca gccaatgtgg ccgtggagga ctgagggaac tcaccatcac ttattcattt
     4621 cccagagaag ttacacttgt ggagttttct gtgatccatc ccacattttc aatgtcagcc
     4681 attaactcca ctcctttcag gggaactgag ggcaaatctg ggcactccag ccccttatca
     4741 cagcaccatg ggcttccttc tgacccttcc cacctcatct gggatccttt gctccagctg
     4801 ctcacttagc aaggtgccct ccctactcct gtgagcacgc tccaaccttg cctccaactg
     4861 tacctacccc atccaaatgg gcttggtcag cctgagtcaa caagcagaac aagtcactga
     4921 gtggcaatgt cacgacttta tttatggtgc ctgtgctttg tctcaaaaat accttctcct
     4981 cctccccaga caataggtgg ggaggaggca gcaaaaatag aacatccctc cctattgcac
     5041 atggacccta tatacaggcc cacctggcag aggccagtgg gactcttggc acattcctgg
     5101 tccctgctgg ggaggggggg aggagtgctg ggtagcatca cacgtgaggt gggaccctgg
     5161 ggcaaccact ctgcttctgg atacttatct ttgcatttct tggtccttgt ttccttcttg
     5221 gtcccatctc tgatgctcag agcaacatct cagcaacatc tccctacctg gctcagcctc
     5281 ccacctctat cctgacctca gagaacccct tggttcctgg ggactctgtg ctttcctccc
     5341 ggttctgagg tcccgagagg ttatggcttc tcagcaactt cccccagagc cttgtcactc
     5401 atgttcacgc gggggaaagg gtgcgtgtgt cagaagcagc agtataaata tggtgcggg
//
LOCUS       NM_001437574            4340 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 16, member 12 (Slc16a12),
            transcript variant 2, mRNA.
ACCESSION   NM_001437574 XM_017589300
VERSION     NM_001437574.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4340)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Contribution of monocarboxylate transporter 12 to blood supply of
            creatine on the sinusoidal membrane of the hepatocytes
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (2), G113-G122 (2021)
   PUBMED   34075817
REFERENCE   2  (bases 1 to 4340)
  AUTHORS   Verouti,S.N., Lambert,D., Mathis,D., Pathare,G., Escher,G., Vogt,B.
            and Fuster,D.G.
  TITLE     Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney
  JOURNAL   Am J Physiol Renal Physiol 320 (3), F351-F358 (2021)
   PUBMED   33459166
  REMARK    GeneRIF: Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney.
REFERENCE   3  (bases 1 to 4340)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Monocarboxylate transporter 12 as a guanidinoacetate efflux
            transporter in renal proximal tubular epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (11), 183434 (2020)
   PUBMED   32781157
  REMARK    GeneRIF: Monocarboxylate transporter 12 as a guanidinoacetate
            efflux transporter in renal proximal tubular epithelial cells.
REFERENCE   4  (bases 1 to 4340)
  AUTHORS   Abplanalp,J., Laczko,E., Philp,N.J., Neidhardt,J., Zuercher,J.,
            Braun,P., Schorderet,D.F., Munier,F.L., Verrey,F., Berger,W.,
            Camargo,S.M. and Kloeckener-Gruissem,B.
  TITLE     The cataract and glucosuria associated monocarboxylate transporter
            MCT12 is a new creatine transporter
  JOURNAL   Hum Mol Genet 22 (16), 3218-3226 (2013)
   PUBMED   23578822
REFERENCE   5  (bases 1 to 4340)
  AUTHORS   Castorino,J.J., Gallagher-Colombo,S.M., Levin,A.V.,
            Fitzgerald,P.G., Polishook,J., Kloeckener-Gruissem,B., Ostertag,E.
            and Philp,N.J.
  TITLE     Juvenile cataract-associated mutation of solute carrier SLC16A12
            impairs trafficking of the protein to the plasma membrane
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6774-6784 (2011)
   PUBMED   21778275
  REMARK    GeneRIF: a model whereby the SLC16A12 (c.643C>T) mutation causes
            juvenile cataract by a defect in protein trafficking rather than by
            haploinsufficiency.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_017589300.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.3682.1,
                                           SRR26643286.4705.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000001.1  241674683-241674923 c
            242-414             JAXUCZ010000001.1  241673939-241674111 c
            415-662             JAXUCZ010000001.1  241621607-241621854 c
            663-766             JAXUCZ010000001.1  241608971-241609074 c
            767-910             JAXUCZ010000001.1  241605846-241605989 c
            911-1490            JAXUCZ010000001.1  241603636-241604215 c
            1491-1750           JAXUCZ010000001.1  241601272-241601531 c
            1751-4340           JAXUCZ010000001.1  241597154-241599743 c
FEATURES             Location/Qualifiers
     source          1..4340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..4340
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16, member 12"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
     exon            1..241
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            242..414
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            415..662
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    502..504
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="upstream in-frame stop codon"
     CDS             553..2013
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 12; solute carrier family 16, member
                     12 (monocarboxylic acid transporter 12)"
                     /codon_start=1
                     /product="monocarboxylate transporter 12"
                     /protein_id="NP_001424503.1"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
                     /translation="MTKITRVGSASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFV
                     EFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGLILG
                     SFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKAFAYGIAMSGSGIGTFIL
                     APVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDPSGPEKSHDRDAQRED
                     CKQASPYSPLTKEWTETRLCCSLQQGYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP
                     YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCY
                     LCLPMLQSFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPY
                     LVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFAKIAKRMKRTQVPFLVKDSDP
                     KLHLWTNGSVAYSIAKELDQKDEESLAKARTGCNLT"
     misc_feature    580..642
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    604..1845
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="Monocarboxylate transporter 12 of the of the Major
                     Facilitator Superfamily of transporters; Region:
                     MFS_MCT12; cd17424"
                     /db_xref="CDD:340982"
     misc_feature    604..1845
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="Monocarboxylate transporter 12 of the of the Major
                     Facilitator Superfamily of transporters; Region:
                     MFS_MCT12; cd17424"
                     /db_xref="CDD:340982"
     misc_feature    order(637..642,649..654,661..663,766..768,919..924,
                     928..936,943..945,1000..1002,1009..1014,1021..1023,
                     1330..1332,1339..1344,1351..1359,1366..1368,1447..1449,
                     1459..1461,1618..1623,1633..1635,1645..1647,1693..1695,
                     1702..1707,1714..1719,1726..1728)
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340982"
     misc_feature    order(637..642,649..654,661..663,766..768,919..924,
                     928..936,943..945,1000..1002,1009..1014,1021..1023,
                     1330..1332,1339..1344,1351..1359,1366..1368,1447..1449,
                     1459..1461,1618..1623,1633..1635,1645..1647,1693..1695,
                     1702..1707,1714..1719,1726..1728)
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340982"
     misc_feature    724..786
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    808..870
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    895..957
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    994..1056
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1081..1143
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1153..1215
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1309..1371
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1417..1479
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1510..1572
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1609..1671
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1699..1761
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1780..1842
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     exon            663..766
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            767..910
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1490
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1750
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..4340
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcagagt caccctcggg gctggcgtca ctgagagcct tggttctccg gggcggggcg
       61 gtgggatctc ctcagtgaca gtgtccggcg ggctctgcct gtggccccgg cccctacggc
      121 gcctccgccc cgtgcgcacc ccgcccctcg gccggaccgg actccagggg ccgtgggaag
      181 gggccgccgt gcagggggca tgtgggctca ccgtcgccag ctctgcagct gtccccgcga
      241 gtgcaagctg atgattcagc gttccgaacc actcgctcgc gttttgtctg gacgctggtt
      301 cgttcttccc agctttgctg agagctatgt gggcaattcc agcggctctg ctgacctagt
      361 ccagaaggaa aaatcttcag gcttgccaag ttcaggaaga ccccgtggct acagatgggc
      421 agtaatccct gtgccaggta gcatcctgaa ccaactttga ggatcaacag gaagttgctg
      481 ggtagcaacc actgaggatc ctaacttact gctgcagtga cctggaaaga gaagaaaacc
      541 aaaattgcaa ccatgacgaa gataactaga gttggttccg catcccctcc agatggaggc
      601 tggggatgga tgattgtggc cggctgcttt cttgttacca tctgcacccg ggcagtcacc
      661 aggtgtatct ccatattttt tgtggagttt cagacgtact ttgctcagga ttattcccaa
      721 acagcatgga tccattccat tgtagactgc atgacaatgc tctgtgctcc gcttgggagt
      781 gttgtcagta accaattatc ctgtcaagcg gggatcatgc tgggtggctt gctggcatct
      841 actggtctca tcctgggctc atttgccacc agtttgaagc acctctacct cagtctggga
      901 gttctcacag gtcttggatt tgcactttgt tactccccag caattgccat ggtgggcaag
      961 tacttcagca ggcggaaagc cttcgcttac gggattgcca tgtcaggcag tggcattggt
     1021 accttcatcc tggcccctgt ggttcagctc ctcattgaac agttctcctg gcgaggagca
     1081 ctgctcattc ttggtgggtt cgttctgaat ctctgcgtct gcggcgcgct gatgcgtcca
     1141 attaccctta aagaggaccc gtcaggccca gagaagagtc acgaccgtga cgctcagaga
     1201 gaagactgta agcaggcatc tccctattca cctttgacca aagaatggac agagacccgt
     1261 ctttgctgct ctttgcagca aggatacggc tttttactga tgtcagactt cgtcgtgctg
     1321 gctgtctctg ttctgttcat ggcctacggc tgcagccctc tctttgtgta cctggtgcct
     1381 tatgctttga gtgtcggagt gagtcaccat caagctgctt tcctcatgtc catcctcgga
     1441 gtgattgata ttgtcggcaa catcacgttt ggctggctaa ctgacagaag gtgtctgaag
     1501 aattaccgat atgtttgcta cctctttgct gtggcactag atgggctgtg ctatctgtgt
     1561 ctcccaatgc ttcaaagctt cccccttctt gtgcctttct cttgtacctt tggctacttc
     1621 gacggagcct acgttacctt gatcccagta gtgactgcag agatagtagg gaccacctct
     1681 ttgtcatcag cacttggcgt ggtctacttc ctccatgcag tgccatactt ggtgagccca
     1741 cccattgcag gatggctggt ggacacgacg ggcagctata ctgcagcctt ccttctttgt
     1801 ggatttgcca tgatatttag ttccatcctg cttggctttg ccaaaattgc aaaaagaatg
     1861 aaaagaacac aggtgccctt cctggtcaaa gactcagatc ccaagctgca tctgtggacc
     1921 aatggatcag tggcctactc tatagcgaag gagttagatc agaaagatga ggaatccctg
     1981 gctaaagcta ggactggttg caatctcaca tgacctgtgt ggccttgtcc tgggaatctg
     2041 caaggctggt ggataccagg ccaccaggtt gttcacagtc tggaaatatt ttattttgac
     2101 agagtatcac ctcccaagta aattattaat actgttttgt taacatattt atatggggac
     2161 aataatgagc aacaaagaaa tctggagtta gcctggagtt ttctcattca ggatttgtac
     2221 tcactacaaa cttagctctg ggagaagggc aggacacagt tgacagggtc agttgtattt
     2281 caggacaact ctaagcagag gccactgtga agagttttca taaaatctgc cccaccccct
     2341 cattctgaac agaagcagtg gtggttgtgc tggcagtggg gatgcagagg tgacttgaga
     2401 acagagcgcc tcaatgttta gagtggcaaa gaaattcttg agactctttg aaaggcaatg
     2461 ataaattaat gtacaacaga cactctctta tccatttccc agccaaccag taaccagtgc
     2521 ctcttccaat gggtagccat cactttgaga gacccaacag tcatcaaaca ctatggctgg
     2581 aacagacttt agagagtggc ttgtggtaat actttatttg taactgtctt gttgaaacag
     2641 aagctctttt cttcagaccg tccccccgac ccccgacact caccctgtca ttactgcata
     2701 ctgactctaa atgtaacaca actcgttcaa tgttgggaca actgctacat ctttcctgaa
     2761 gtgattgtaa taccccagga atcctcagct ttttcttctc tttgaaaaaa aaaggttcta
     2821 atttgaactt taggcacatt ccttttagga atagaaaaat gttgacagta ttccagttga
     2881 gcagtaattg aattcctgag tcagcagtcg ttagagtcat cattatccaa aagaggggtt
     2941 gggggttttc ttatcataca aatgttctaa agatggcctt tggagttcac catatccctt
     3001 gttggatcat agttataaat ctgactcatt ggcttagaag tgtctgctcc atcgcttctc
     3061 ggccttttgg ctaagatcaa gtgtagaagt gtctgctcct tctcggaggc cagactttgc
     3121 agggacatga aatcctttct gaattttcat atcagagaaa agtacaaaaa agaagaaagg
     3181 tggggccaca tcttatcccc agctgtttta atatccacac aattaagagt cctgaatccc
     3241 caatcaggta ccattttcaa agaaggacaa gttatataat aaaaggggga tgttttcaat
     3301 tgttcaagag tttaaatgca agtcacaagg aaacgttgtg aactcaatga ccatttaacc
     3361 tactgtcccc aagaagcctc agagtggctt ttgccagaca tggtgctggg agaaataaca
     3421 aagcgttgag ggatggctga ggtgactgag ttctcacttg aactgagtat gtttgtgttg
     3481 ctatactgct ttcataatga gatactggct tgattcgatg gagagatcgg cactactcac
     3541 attgtagttt ttcacagaaa aatgtgagtg tcctgtcttt actcagtctg ggactttagt
     3601 tttgaatcca ttcactgtgt tatttgcaat tttaaaaata ctttgaggag atctgtaaaa
     3661 attcaaagtc aaaattgaat actcaaaata tattcaagat gaaatacttg ttttggaata
     3721 gcactttacc ctaaatgtca tttttaatca taaaaatgct ttttcttaaa aaagtaagta
     3781 ctcttatttg tatgttttta aagaattgat tgtaaatttt gtttgtgtga ttctataata
     3841 tagtttctct attgtgttta taaaaaacta ggataatgat caaaggtttt aaacttatat
     3901 aaaacatttt agatcttttg actttatccg tgcaataaat ttgcattcta actttcttgg
     3961 gaaaacattt ttgaagaacc agtaagaaaa actgtagatc ttacagttta cagtttggtc
     4021 acctgcacaa catgttacta aaacattttc tccatgtatt taaacagttg gttccaaagc
     4081 taaggaattc ataggaatgg ggcattttgt ggagtcaaga ataaaccagt agagaaatta
     4141 ttttatgcct taaatatttg ttcacccaac tgtaggttca cctttgtaac taagtaggaa
     4201 aacaagacag aatctaaatt ttcaatgtgc tattttttct gttgcttaaa ttagaattct
     4261 actaatgaat ccgatgtgta ggctaatgtt ttcctagttc aaaggcaaaa taaaatggat
     4321 ttatactcac atgtttcaaa
//
LOCUS       NM_001437560            5039 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 12, mRNA.
ACCESSION   NM_001437560
VERSION     NM_001437560.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5039)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1509878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000001.1  254851842-254851979
            139-312             JAXUCZ010000001.1  254856186-254856359
            313-459             JAXUCZ010000001.1  254856944-254857090
            460-561             JAXUCZ010000001.1  254857203-254857304
            562-3418            JAXUCZ010000001.1  254857400-254860256
            3419-3472           JAXUCZ010000001.1  254860529-254860582
            3473-3530           JAXUCZ010000001.1  254861917-254861974
            3531-3598           JAXUCZ010000001.1  254862695-254862762
            3599-4316           JAXUCZ010000001.1  254863590-254864307
            4317-4454           JAXUCZ010000001.1  254865878-254866015
            4455-4515           JAXUCZ010000001.1  254866114-254866174
            4516-4637           JAXUCZ010000001.1  254866293-254866414
            4638-4789           JAXUCZ010000001.1  254866843-254866994
            4790-5039           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5039
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..138
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..4893
                     /gene="Pprc1"
                     /note="isoform 12 is encoded by transcript variant 12;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 12"
                     /protein_id="NP_001424489.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MSTWLLSQAVGHLVSALEPHCRELGVSQPLPPSLACAGTSGLEV
                     HEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLISLIEDFGES
                     RLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLHKLLNLSRT
                     PPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLPSWRSSRPR
                     PRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPEEEDKSGAA
                     NVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLPEGCVVLEI
                     VGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGTEDGVPKVA
                     PCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKKKKKEQPTA
                     CLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGKPRAWARAW
                     AAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSARADSIPVN
                     SVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVAIPTSNHLS
                     PADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPSLEPSDHPK
                     VITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDRNSQPPAGK
                     WPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSPTPEPSASK
                     LMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLPPLLPLPAS
                     GPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYSCLPPPPAM
                     PIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPFWSTVSPPP
                     LSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAEPTKLEAQP
                     VPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRPREKPISTA
                     TKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGIEASDLSSL
                     LEQFEKSEAKKECPLPAPADSVAVGNSGIDTPQEKKPLDRLHAPELANVAGLTPPATP
                     PHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGVRGPSPVHVG
                     SGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAAPPLPCTTTS
                     QEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQRSMRCYRKA
                     CRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSLSPPNKRWRR
                     SSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRSYRSNDHYQRQR
                     VLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYR
                     YAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFD
                     SLDFDTLLKQAQKNLRR"
     misc_feature    <1117..2514
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1117..2514
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1873..3330
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1873..3330
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2914..4065
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2914..4065
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4519..4791
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4519..4791
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            139..312
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..459
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..561
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..3418
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3472
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3530
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3598
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..4316
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4454
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4515
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4637
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4638..4789
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4790..5039
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaaggga tgtccacgtg gctcctgtcc caggctgtcg ggcatctagt atccgcgctg
       61 gagccgcact gccgggaact gggtgtgtcc cagccgctcc cgccatctct tgcctgtgct
      121 gggacctctg gtctggaggt ccatgaggaa ggagatgact ctagctttgt cagtctttct
      181 cgactgggcc catctctaag ggagaaagac ctggaaatgg aggaactgat actgcaggat
      241 gagacactac tagagaccat gcagaactac atggacgcct cccttatatc cctcattgag
      301 gattttggag agagcaggct atctttggag gaccagaatg agatgtcgct gctcacagct
      361 ctgacggaga tcttggacaa tgcagattct gagaacctgt ccccgtttga taccattcct
      421 gattcagagc tgctcgtgtc tcctcgggag agctcctctc tgcacaagct gctcaatctc
      481 tctcggacac ctccagaacg tgaccgcatc cccgcaatgg accctttggg gcccagcgca
      541 ggaagtagtc gggtgagtgg ggttgagatg tcccttgcag attctccgtg ggacttctct
      601 ccacctcctt tcttggaaac ttcttcccct aagctgccta gctggagatc ctcaagacca
      661 agacctcgat ggagtcagtc tcctcctccc cagcagcgca gtgatggaga ggaggaggaa
      721 gaggttgccg gcttcagtgg tcagatgctt gatggcgaac ttgacaactc ggtgaatacc
      781 ttggatttcc ccatgcacct ggcatgccct gaggaagaag acaagtcagg ggcagcaaat
      841 gtggcagtgt cagcacctgg tgacgagagc atctcctcct tgagtgagct ggtacgggcc
      901 atgcacccct actgcttacc caacctcacc cagttggcat cacttgacgc tgagcttcag
      961 gagcaggctg atgatctgac actgcctgag ggttgtgtgg tgctggagat tgtgggccag
     1021 gcagccacag ctggtgatga cctggagatc ccagtggtcg tgcggcagat tccttcagga
     1081 tcccagtctg tgctcctaga tgggtctgta gggactgatc ctgccttgca gctactcatg
     1141 cccgccatgg agcctggaac agaagatggt gtgcctaaag tcgctccttg ccctgatcaa
     1201 gaattaccac tgagctctgc ctgcttattg gagcccaggg acatcatgga gtcattggcc
     1261 cccaaggagc ctcggaacct acctgccaat gcaagtgagg gttctcagag agttcccaga
     1321 aagggtagga agaagaagaa gaaggagcag ccaacagcct gtttggaagg ctgtaccagg
     1381 aggctgaggt catcttctcg tggacagtct actgtggcta cagaggtgaa ctctcaggca
     1441 ggcaacttac agaaacagcc tcaggaagag cttcagagag agactgcggc ccctcagagc
     1501 agagggaagc cacgggcttg ggctcgggcc tgggcagctg ccttggagaa aactgggtct
     1561 gaagacccag aggaccagaa tgcaggacag gatagtcctg ctgaggaaga tgttctagaa
     1621 ctccgtccta agctggtgga gactagccaa gccgacccca cgctctcact aaacgactct
     1681 gctcgagctg actccatccc agttaactct gttgaaggtg actccactgc agtggacact
     1741 gctgtacctg ttgaccaggc ttcatcttgt acagagctgg ttggttctct ctcaggaggc
     1801 ccaattctga gtagcccagt cctagatgac aggacaggag ttgaacctgc agtggctatt
     1861 cccacttcaa atcacttgtc tccagctgat gctatcctag ctaacccagg gacagctgac
     1921 cctgctccaa atggcctggc tccaggagat cctgtgctag ttaagtgcag accaactgat
     1981 cctagacgtg cagctgctgc tgccactgct gctcaggggc ctcgtccttc cctagagccc
     2041 tcagaccatc ctaaggtcat cacccctgaa gtcaaggatg ctggaggtcc tctgaaggtg
     2101 gaaggtagta ccagtgctac aacccaggaa gccagacctc ggcccctcag cctatctgag
     2161 taccgtcaac gacggcggca acggcaaata gaagcagaag acaggaattc tcagccccca
     2221 gctggaaagt ggccaagtct cccagagacg cccaaagggc tggcagatat cccttgtctt
     2281 gttccatcag ccccaaccaa gaagacagcc ccacagagaa gccctatagc tgtaccagag
     2341 acttgttctg tatctgtggg ttctaaccct gtttccccta ctcctgagcc atctgcaagc
     2401 aaacttatgg tttcaactca ctctgaacag gtgtcatctc atgagatgcc acttccagtt
     2461 agacttcccc ctcctacatt gcagtctatg gctcctgctg ggcccacccc ttctacagtg
     2521 cccacgccat tgcctttccc tccgagctta cctcctctgc ttcctcttcc tgcaagtggt
     2581 cctggtgtcc ccagcctgcc cccacctcct ttgcaacctc ctggacttcc agtatcaatg
     2641 agacaaatgc cacctgaccc ctatactcag tatgcccctg tgccgccctg gccttgttac
     2701 ccctctgtat ctccttctgg ctattcttgt ctgcccccac caccagcgat gcccatagtg
     2761 tcgggtaccc ctggtaccta tgctgtaccc ccaacttgca atgtgccttg ggtaccccct
     2821 cctgcaccag tctcacctta tagctccagc tctgcctatg ggtcccttgg gtggggccca
     2881 gggttgcaac agcctccctt ttggtctact gtttctccac ctccattgtc ttcagcctct
     2941 actggtagag ctgttccccc acccagtgtg gaacccagta acagttcagc tggtcctccg
     3001 gaagatacac ttcctgtgcc agtgacccct tccctgagct ctcggccagc cagccccata
     3061 gctccaccag cagaacctac gaagctggag gctcagccag tgcctgtctc tccccaaccg
     3121 aaacacaaag tgtcccctgt ggtacagagt ccccagatca aggttctacc aactctgtct
     3181 gctgagggcg tggctattgg ggaatctgaa tcagagaggc taaagccgga gacccaggag
     3241 aacagaccaa gggagaagcc tatctctacg gctacgaagg ctgttctgtt accaaagcag
     3301 agcactgtcg caaaactgcc tgccgtccat ccagcccggc taaggaggct gtccttcctg
     3361 cccaccccac gtgctcaggg ttctgaggat gtggtgcagg cattcatcag tgagattggg
     3421 attgaagcat cagacctgtc cagtctgttg gagcagtttg agaaatcaga agccaaaaag
     3481 gagtgtcctc tcccggctcc tgctgacagc gtggctgtag gaaactcagg cattgacact
     3541 ccccaggaga agaaacccct agaccggtta cacgccccag aactggccaa cgtggcaggg
     3601 ctcaccccgc cagctacccc tccccaccag ttatggaaac ccctggctgc tgtctcactg
     3661 ttggccaaag ccaaatctcc taaatctact gcccaagagg gaaccctgaa gcctgaagga
     3721 attacagagg ccaaacctcc agctgcagcc tgcctccaag aaggggtccg tggccctagt
     3781 ccagtccatg tgggctctgg ggaccatgac tattgtgtcc gaagcaggac acccccaaaa
     3841 aagatgcctg ccctagtcat ttcagagatg ggctctcgat ggaatgtcaa gcgccatcag
     3901 gacatcacta tcaaacctgt cttgtcattg ggctcagctg cccccccact cccatgcaca
     3961 accacttccc aggaaccgct tgatcacagg actagcagtg agcaggcaga tccgtcagcg
     4021 ccttgttttg ccccatccac cttgctgtct cctgaggcct caccctgccg gaatgaaatg
     4081 aacactagga ctccctctga gcccccagac aagcagcggt caatgcgctg ttaccgaaaa
     4141 gcctgcagat cagccagccc cccaagtcgg ggctggcaag gccgccgtgg ccgtagcagc
     4201 cgttctgtca gctctgggtc cagccggacc agtgaagcat cctcatcctc atcggtgtct
     4261 tcctcatccc ggtcccggtc caggtccctc tcccccccaa acaagaggtg gcgaaggtcc
     4321 agctgcagtt cctctggacg gtccagaaga tgttcctcct cttcctcttc ttcctcctcc
     4381 tcatcttcat catccagttc cagaagccgg tctccctctg tgtccccttg caggagaagt
     4441 gaccggaggc ggcgctctta ccgttcaaat gaccattacc aaaggcagag agtactgcag
     4501 aaggagcgtg caatagaaga gagaagggtg gtcttcattg ggaaaatacc tggccgcatg
     4561 actcggtcgg agctgaagca gaggttctct gtttttggag agattgagga gtgtaccatt
     4621 cattttcgtg tccaaggtga caactatggt ttcgtcactt accggtatgc tgaagaggca
     4681 tttgcagcca ttgagagtgg ccacaagttg cggcaggcag acgagcagcc ctttgatctc
     4741 tgctttgggg gccgaaggca gttctgcaag aggagttact ctgatcttga ctccaatcgg
     4801 gaagactttg atcctgctcc tgtcaagagc aaattcgatt ctcttgactt tgatactttg
     4861 ttgaaacagg cccagaagaa cctaaggagg taaccctggg ctttcctccc ccatccattt
     4921 tctctggagg tgtccaacct ctcaaccccc tcccctactc taggggagag agctgctagt
     4981 gtggaaagac ttttataagg aaatgaaaaa aagttaaata aaaatatgtt aaatcggga
//
LOCUS       NM_001437576            5492 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001437576 XM_039080839
VERSION     NM_001437576.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5492)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5492)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5492)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5492)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5492)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5492)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5492)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5492)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5492)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5492)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_039080839.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1706.1,
                                           SRR26643298.3378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345329,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-170             JAXUCZ010000001.1  130365401-130365453 c
            171-364             JAXUCZ010000001.1  130337632-130337825 c
            365-568             JAXUCZ010000001.1  130317243-130317446 c
            569-700             JAXUCZ010000001.1  130293170-130293301 c
            701-920             JAXUCZ010000001.1  130290825-130291044 c
            921-980             JAXUCZ010000001.1  130289823-130289882 c
            981-1168            JAXUCZ010000001.1  130277028-130277215 c
            1169-1192           JAXUCZ010000001.1  130271166-130271189 c
            1193-1319           JAXUCZ010000001.1  130267560-130267686 c
            1320-1446           JAXUCZ010000001.1  130263566-130263692 c
            1447-5492           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5492
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..170
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..364
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    299..301
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             311..1816
                     /gene="Mef2a"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 2"
                     /protein_id="NP_001424505.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIP
                     PSSKGMMPPLSEEEELELNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAY
                     NTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSI
                     NTNQNINIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVD
                     SLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    311..>1015
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    311..>1015
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    <683..>1444
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <683..>1444
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            365..568
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            569..700
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            701..920
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            921..980
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1168
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1192
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1319
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1446
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..5492
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcggaa
      121 ttgcatcttg tggaaaagga acaaagaaga actttctgca aggataaaat atttttaaga
      181 caatttcagc ggcagccttg gactggaagg ttaaataata ggaactgtgt acgatgcatt
      241 aggatattga agaaaattag cttctgaatt aattatttgg aatataagga agaaaaggtg
      301 acttttgaaa atggggcgaa agaaaataca aattacacgc ataatggatg agaggaaccg
      361 acaggtgact tttacaaagc gaaagttcgg attgatgaag aaagcctatg aactcagtgt
      421 gctctgtgac tgtgagatag cactcatcat cttcaacagc tctaacaagt tgtttcagta
      481 cgccagcact gacatggaca aagtccttct caagtacacc gagtacaacg agcctcatga
      541 aagcaggacg aactcggata ttgtggagac tttaagaaag aaaggcctta atggttgtga
      601 gagccctgat gctgacgatt actttgagca cagtccactc tcggaggaca gattcagcaa
      661 actaaatgaa gatagtgatt ttattttcaa acgaggccct cctggcttgc cgcctcagaa
      721 cttctcaatg tctgtcacag tccctgtgac cagccctaat gctttgtcgt acactaaccc
      781 agggagttca ctcgtgtcac cgtctttggc agccagctca acattagcag agtccagcat
      841 gctgtctcca cccccagcca cgctacatag aaatgtgtct ccaggagctc cgcagagacc
      901 accaagcact ggcagtgcag gtgggatgtt gagcactaca gacctcacgg taccaaatgg
      961 agctggaaat agtcctgtgg ggaatggatt tgtaaactca agggcctctc caaatttgat
     1021 tggaaatact ggtgcgaata gtgtaggcaa agtcatgcct acaaagtccc ccccgccacc
     1081 aggtgggggc agtgttggaa tgaacagtcg gaaaccagat ctacgggttg tcattccccc
     1141 ttcaagcaag ggcatgatgc ccccactttc ggaggaagag gagttggagc tgaatgccca
     1201 aaggataagt agttctcaag ccacacaacc tcttgccacg cccgtggtgt ctgtgacaac
     1261 tccaagcttg cctccgcagg gactagtgta ctcggccatg ccgacagcct acaacactga
     1321 ttactcattg accagcgctg acctgtccgc cctgcaaggc tttacttccc ctggaatgct
     1381 gtctctgggg caggcttcag cctggcagca gcaccatcta ggacaagcgg ccctcagctc
     1441 tctagtggct ggagggcagt tatctcaggg ttcaaatttg tccattaaca ccaaccagaa
     1501 catcaacatt aagtcagagc caatttcacc tccccgtgat agaatgaccc catcaggctt
     1561 ccagcagcag cagcagcagc agccacagca gcaaccaccg ccacaacctc cacagcccca
     1621 gccccaaccc cggcaggaaa tggggcgctc ccctgtggac agtctgagca gctctagcag
     1681 ctcctacgat ggcagtgacc gggaggatcc acggggcgac ttccattctc caattgtgct
     1741 tggccgacct ccaaatgctg aggacagaga aagcccctct gtaaaacgca tgaggatgga
     1801 cacatgggtg acctaaggct tcctggttca tgtctgttct ttgtgttact gcagtgaact
     1861 gccctacata tcttaaattg gtgaataagg acatgagttc aatatattta tatgtacatg
     1921 catacatata tatcccttta catatatatg tatgtcggtg tgagtgtgtg tatgtgtggg
     1981 tgtgtgttgc atacacagaa tcaggcactt actgcgactc cttgtaggta tgcagatgtg
     2041 tgcacacggc acacagagca ccttgtagag acagaccagc ctggcacttc cttggactac
     2101 ttgtctccta agataaagtt tttgcagaga aacgtgtacc catatataat tcttccacat
     2161 tagcctgcag aaacctaggg gcccctattt gttttattta cctgtgcggt gactgtagtt
     2221 acttcaaaaa aaaaaaaaat tgctttgtag aacagagcag tagaaaagca ggaaccaaga
     2281 aagcaatact gtacataaag tcatttatat taataaccca acctggcatg ggtctattgc
     2341 agaggggtgc atgggcaagg gctgtctata ttaaacagac acagtaaaca aagagcccca
     2401 cacataactg ttttgcacgt gcaaaaaaat gtattgggtc aaagaagtga tttttagcta
     2461 ttaaaaagag agaatagaaa acacgcatga aatattcaga aatactagcc tagaaatata
     2521 gagcattaac aaaataaaat taatatatta agttataatt ggaatatgtc agaagtttct
     2581 tttacattca tatctttaaa aattaaagaa actgatttta ggtcatgtat attttatatg
     2641 aaagaaaaca cccttaatga attgatgact atatataaaa ttatatccac tacttttgaa
     2701 cacattctgc tgaattattt atataagcca aagctgtatg ttgtaacttt tttttttaaa
     2761 gaatagcttt atcttgtttt aactttttag ttttatttta agagggaaga aaaaaacaaa
     2821 aatatcttgc aagcagaacc ttggaaaaaa aaaagccatg aacattatta ttctatatgt
     2881 aaattaaaag tcgagccaaa ctctttgtgt atatagcatc ttaaatatat taccaccttt
     2941 gatgtaagta cctatgtatt gtatggtcac cagattaaaa agtatatttt tgtggattgc
     3001 caccaatttg gggggaaagg cgaagtcctt aagtagagta ttcactgttt aatatttact
     3061 attttgttaa atatactgta ctttggattt taattattag cccagttttt cagaggattg
     3121 tgtaaagggg tttcccctca ctggtggtga atgtgtgatg ttctgttgta atctttgtgc
     3181 tgtatggggt gagcatcatt atatatttta tatgtgtaca taaatagcaa agtggcaaaa
     3241 aaattggtgt taagttcatc ctgcataaat ataaaatgtg ttgtaacaga ttttataagg
     3301 cattatttaa aacttgcctt ttgtgaggga aaaaaaaaaa cagtagaaag atgacctaat
     3361 ttaactaata ttagagaaaa tggctgagta gtagatgagc acaaaggttt tataagtggt
     3421 aaataattag gaaaatattt gtaggggaag ggatcttttc tccttgactc taaagataga
     3481 atgatgcagc tggttacaaa atccaggagg gctttagcgt cccgtgcgtg ggaaggcacg
     3541 ggcgtgcagg gagcagctct cctatggtgc agatccccga cacaattctt gctgtcctga
     3601 cggaaactgg tgccaccctc agcttggatt ttgaacaagg ccttactctt acagggagac
     3661 agctcgttgg tgatggcaag ttcatccgtt tactgggctt gtgccatgaa caaaattcaa
     3721 agtcctgtat atcttttatc ctagattttt aaatactcct tttcctgaaa aaacttaaag
     3781 agtttaaaaa tggctgctat tttatactga acaatgttga gcagctacct gcagttttta
     3841 cttacatttt gcttttcccc tcgattccct aaattatgct ccttttgatg tctcctcatc
     3901 tgctgtcccg acagctcatc agccaggttt cctgcctggc cgcacacagg tattcggtcc
     3961 atgcaccgtg gtgagcacag gctgtgcact ggagagcctc actgacagtc tgggtagcac
     4021 atgttagtgg aagccaagga agtggggacg gtgtctcatc tcctctgtgg tctcagcact
     4081 tggctcttcc tcagagaagg ttaggttttc ttcctcaagt gtactgagtt gacttacagg
     4141 cacgttcctc ataaggtcac agtctcccaa cactgacttt ccaagatacc ccttaccact
     4201 ttgtaaacca tttatagctt tgaaagtatt aagtgaccct ttcattatta tttatgcatg
     4261 ttcatgaact tctgctgtat attgggatag gagttaacac attcacattt actgtctatt
     4321 ttcttgtgtg ccttatgaga tggcttctct gactgtatct caatagtctt tctatgcagg
     4381 tttataatca gtacaactac tgttttctaa aggaatatta cacacggctc ggagtttgta
     4441 cttaaattac actgaccaag tcacaatgta ttccgttttc aggaactgaa tatctgactg
     4501 ttaatctttt cccatatgcc cagtgtgatc tggagcatat gggtctgaca tccttcaccc
     4561 agatgctcat gtgtgaacac atccacatcc acagctctca gtggaagcca gcctagagta
     4621 gggaggacac tgacggtgtt gctttaaact gacttttctt accctttgag actcatgtgt
     4681 tttgtataag acaccatcac aagaaagttt tctcccttca gataacatat tttattatta
     4741 aaaagaaaaa caaaaaaagc ttttaagttg cactggacgt gggccgttcc ttcggaactc
     4801 tttggatcta cactgagagt gagtgtcgcc gctctgtgaa cacaggtggt cccagtcaaa
     4861 actccatcct ttgagcccta attacatcca ttgtgttaca aaactaaatc aggggtttgt
     4921 tctaaaagaa caatacatgt ctcaccattt cctttcaact gtaaagacga ctgataatgt
     4981 attaacataa tttctgtatt aaccatcatg cgcacaagaa atacatagta aatacggaac
     5041 ctgaaaactc ctgcatcgga tcataaaagc tagatgatta gaatgtgaaa agaactttac
     5101 agatgtaaaa cttttatttc tctgtagaaa ctttcttcac tttgctgtgc aagaagacac
     5161 tgctttgcta tatttaaaat ggctttttta aaaagagatt tatgtatttg gtaaatgttt
     5221 gtagtcaaca gttcacacaa agaagctgta cacggtttga tcatgtaaaa ccgtttggcg
     5281 gcacaagctg gactttgttg ccatccttga gatgaacctt ttaagaaaaa taagttaatc
     5341 tcaatttttc cctgaatgtg ttgttttttc ttcattatac aataaatatt atagtgaagt
     5401 ttttatcaaa tggttaagac aatgctagag gttgttgtaa gctatttgtc tcctgcactc
     5461 actccagtaa agatggcctg gctttgacca ta
//
LOCUS       NM_001437592            5563 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 3, mRNA.
ACCESSION   NM_001437592 XM_006228279
VERSION     NM_001437592.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5563)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5563)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 5563)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 5563)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 5563)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006228279.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.1169.1,
                                           SRR26643297.808.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000001.1  78402016-78402166   c
            152-309             JAXUCZ010000001.1  78401477-78401634   c
            310-350             JAXUCZ010000001.1  78398316-78398356   c
            351-409             JAXUCZ010000001.1  78398010-78398068   c
            410-571             JAXUCZ010000001.1  78397058-78397219   c
            572-721             JAXUCZ010000001.1  78396669-78396818   c
            722-804             JAXUCZ010000001.1  78396228-78396310   c
            805-1069            JAXUCZ010000001.1  78395632-78395896   c
            1070-1196           JAXUCZ010000001.1  78395199-78395325   c
            1197-1285           JAXUCZ010000001.1  78394918-78395006   c
            1286-1360           JAXUCZ010000001.1  78394740-78394814   c
            1361-1509           JAXUCZ010000001.1  78394489-78394637   c
            1510-1651           JAXUCZ010000001.1  78392927-78393068   c
            1652-1680           JAXUCZ010000001.1  78392786-78392814   c
            1681-1810           JAXUCZ010000001.1  78389932-78390061   c
            1811-1942           JAXUCZ010000001.1  78389705-78389836   c
            1943-2051           JAXUCZ010000001.1  78389331-78389439   c
            2052-2226           JAXUCZ010000001.1  78389017-78389191   c
            2227-2359           JAXUCZ010000001.1  78388632-78388764   c
            2360-5563           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..5563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5563
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..151
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..309
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    215..217
                     /gene="Eps8l1"
                     /note="upstream in-frame stop codon"
     CDS             293..2446
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001424521.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     misc_feature    386..778
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    386..778
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    order(407..409,644..646,704..706)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(407..409,644..646,704..706)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(602..619,665..667,734..736,746..748)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(602..619,665..667,734..736,746..748)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    1736..1894
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    1736..1894
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    order(1736..1753,1757..1759,1766..1768,1775..1783,
                     1802..1819,1823..1849,1862..1873,1883..1894)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1736..1753,1757..1759,1766..1768,1775..1783,
                     1802..1819,1823..1849,1862..1873,1883..1894)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1757..1759,1769..1777,1826..1834,1838..1840,
                     1865..1870,1874..1885)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1757..1759,1769..1777,1826..1834,1838..1840,
                     1865..1870,1874..1885)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    2159..2356
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     misc_feature    2159..2356
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     exon            310..350
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..409
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..571
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..804
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1069
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1196
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1285
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1360
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1509
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1651
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1680
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1810
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1942
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2051
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2226
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2359
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..5563
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagcc agcaggcagg tgagaaggcc aggcctagtg tgagtgagga gagctgagtt
       61 gtagggtctt ggatctgaga cacaaggtat cctctggacc ccggatctga acaaggagag
      121 ctgatctaga ttcttggatc tgagagataa ggagccaggc tggtgcctga acatctcagt
      181 ttgagggagg aggcttggat caggatcctg tgcctgaagc caagtcagtc actcacgtct
      241 ttgctggctc tcaaggaacc tccaagcgga cagagcacct cttctggcca ccatgagcac
      301 caccacaggg cctgaagctg cacccaaacc aagtgcaaag tctatctatg agcagagaaa
      361 acgttactcc actgtggtta tggctgatgt gtcccagtat catgtcaatc acctggtcac
      421 cttctgcttg ggggaggaag atggcgtgca cactgtggaa gatgcttcca gaaagctggc
      481 agtcatggac agccaggggc gtgtctgggc acaggagatg ctactgagag tgtcacctgg
      541 tcatgtcact ctgcttgatc cagtctctaa ggaggaacta gagtcatatc ctctcgacgc
      601 catcgtacgc tgcgacgcgg tgatgccccg aggacggagc cgctcgttgc tgctcctggt
      661 gtgccaagag ccagagcgtg cacagccaga tgtccatttc ttccagggcc tgctcctcgg
      721 ggcggagctg atccgtgagg acatccaagg ggctctgcag aactaccgct ccggacgtgg
      781 ggaacgcagg gcggcagcac tcagggctac gcaggaggag ctgcgacgcg gtgcctctcc
      841 agcagcggag accccgccct tacagcgtcg cccttctgtc cgcgcggtga tcaacacggt
      901 ggaaccatcc gcggtgcgcg ggcgacccca agtggagcca attccagaga ctgaggaagc
      961 gaggaaaccc gacccagcgc gcacgacgac taggagctct gatcctacct ccccagacct
     1021 gggcccaagg ggtcctgagc tggccggtct gcaggcggag cgggatgtgg atatcctgaa
     1081 ccatgtgttt gacgacgtgg agagttttgt atccagactg caaaagtcag cagaggctac
     1141 ccgggttttg gagcaccgtg agcgcggccg caggacacga cgccgagctg ctggagaggg
     1201 cctgctgacc ctaagggcca agccacccac agaggctgaa tacactgatg tgcttcagaa
     1261 aatcaaatac gccttcagtc tgctggcccg gttgcggggc aacatcgcca acccctcctc
     1321 tccagagctg ttacactttc tgttcggacc tctgcagatg attgtgaaca cttcaggcgg
     1381 ccctgagttc ccgaggagtg tgcgacgacc acatttgacc ttggaggctg tggcgctgct
     1441 ccgcgacaat gtcactcctc gtgaaaatga actatggacc tcactggggg actcctggac
     1501 ccgcccaggg gtggagctgc cccctgaaga agggtctcca tacagtccgg aattctacag
     1561 cggttgggaa cctccggcca ctgacccgca gggccgcccc tgggaggacc cagtggaaaa
     1621 acagctacag cacgagaagc ggcgcaggca gcaaagcgcc ccccaagtcg cggtcaatgg
     1681 tcatcaagat ccagaactgg aaactgagtc ccagctagaa gagaaagcca gaaaatgggt
     1741 tctgtgtaat tatgacttcc aggcccgaaa tggcagcgag ctatctgtca agcaccgaga
     1801 tgtgttggag gtcctggatg acaggcgcaa atggtggaag gttcgggacc atcaaggaca
     1861 agagggctat gtaccctata atatcctgac accccaccct ggacctcagg tgcactgcag
     1921 ccaaagctcc gcaataaacc tagagactag cccacctcct cccccacctg ctgcagctcc
     1981 agcccccact caggtgcggc cccagtggga cagttgcgac agtctaaaca gtttggatcc
     2041 cagcgacaag gagaaatttt cccagatgct ttgtgtcaat gaggagctgc aggcgcgcct
     2101 ggcgcagggc cgttcgggtc ccagccgggt aaccccgggg cttcgagccc cggagcccca
     2161 gctcagccca cgctctgagg cctcggtggt ccgtgcctgg ctgcagacca agggctttag
     2221 ctccgggact gtggatgcgc ttggagtgct gactggcgca cagctgttct cgcttcaaaa
     2281 ggaagagttg cggtcggtgt gcccggaaga aggggcgcga gtatatagcc aagtcactgt
     2341 gcagcgggcg ctactggagg acagagaaaa agtatcagag ctggaggccg taatggagaa
     2401 acaaaagaaa aaagtggaag gcgagaccaa aacagaagtc atttgatcct ggttcattca
     2461 taaaaagtga tgagatggtg gggttcccag cgccccgaaa gacaacagtc accagactcc
     2521 tcccccaacg tcagtagcag tagatgccgt aaaggaccgc ccaccctggg ttccccgcgg
     2581 tcctggcggg cggactgcat tgacagtgct gaccggaacc tttccagagg gactgatggg
     2641 aatggggaag ggaacagagc atggacacta ctagaaaggc acgcccaaga ggcgcgatga
     2701 tggccctgtg cgttgtgatg cgctataaac agcctccttt taggctatgt ccacctgctg
     2761 tcccccccca cacacacccc ctctcttgcc ggccaccaag atgccaggaa tctagaagac
     2821 atccatattt tctctccaca aacctggaga ttccaaccca ggcttcctct taagcaccaa
     2881 tctatccttg ctctaacact atctacaatc tctctctggt tcaaaatcct ttcctgtcaa
     2941 ctagcgtgag gcctgggatt ttcctttcaa aggcagaggg tgtctccttc caccccccat
     3001 tttgggtcaa cccctccaat cacaggcatt tccgcactta ctgcttctgc tggttggagc
     3061 agcttccatc aatgtggctc aactcaccta cattccatgg atgcctgtgc cagccactaa
     3121 ggattcagct atgaagatcg ggatgctata ggctcttggg tcttccagtc cccagaactt
     3181 tctccctgcc aagtcctgca acttgtctgg tttatttagg tggctagtaa gagctggttt
     3241 tctcattgag actagatacc cctaaggttt ttttttttcc tgctgtggca cttccctttg
     3301 catccctaaa acacttcaag agtcacacca gtgcagttgg cctctgctct ccaggcagtt
     3361 cagctcttac ctgagccacc agtggcacac ctcaaatcca agctagaaaa gccagccttt
     3421 gggctgacag cttcactata cccactttgc tccagaacac tatccacaat agatctcttt
     3481 cccacttcct gtctacctct caagcatgtc tcttggcttc tcccgacaga tgggataaaa
     3541 cctaacccca gcatgaaagt tgatatacat gaccactcca ggttcagggc cctcttcctc
     3601 ccttttcagg accccaagca ttggttcgtg ctgttggctc tgctaggaat gtcctggcct
     3661 tttggagtct aatcactgcc tgtcgttcct tatgtcaggg ttgggtggtt agttggttga
     3721 ttggttttgt tggagatagt ctggatatag cctcaaagtc tcaattctgt ttcagtttcc
     3781 tgcatgctga gattcctggc agatgccctc ctgccttctt ttctaagaaa cttaaaaaca
     3841 caagcagttt gcccaaactg tttttgactc tgcagtgagc tcccaggctc caggctgcag
     3901 gctgccgtgc aggcagggac cagctggctt gctggaacac cagatgcctc tagctctcta
     3961 tggtctggaa tctgatcatt tctatctgct tatcctgact tcatcctttg ttgatcaccc
     4021 tgtccgtcac tcctccaatc tgtatcgatg ttcagacata gggacctgtt acaactcaag
     4081 tcagatggca gtctgctggc cagacctccc acctcagagc tcaagtcctt agtagagcca
     4141 catccctgca caaagccagc agcacttcaa cacttcctct gctattcagc cccaagtttc
     4201 ttcctgcacc ttagcatgcc aggcctactc taccctatga cctttgcatc tcatcactga
     4261 aaatgggctt ccttcagaca tatggctcac tctgctacct tctagttcca cgtgtcatgt
     4321 cttgggtcta ctttgactac cataaacacc atacatacac accagataca tacccaacat
     4381 acaccataaa catcagccat gccacgcacc acacaaaatg cacaccacac acacaccgtc
     4441 cacccctgac aacacccatc cacccacatc cacttccctt ctctttctcc acagcactac
     4501 agctgaaatc catacactag ttacctctct cctgcagaac ctggctcctg gcctaagcta
     4561 ctcactcttg ggactccagt aggtaggaca gagcccagct ggtagtgtag gcagttgctc
     4621 ctgactataa gaatgaaggt acaatgaatc acaagactgc ctcctactat tccagccaat
     4681 gtggccgtgg aggactgagg gaactcacca tcacttattc atttcccaga gaagttacac
     4741 ttgtggagtt ttctgtgatc catcccacat tttcaatgtc agccattaac tccactcctt
     4801 tcaggggaac tgagggcaaa tctgggcact ccagcccctt atcacagcac catgggcttc
     4861 cttctgaccc ttcccacctc atctgggatc ctttgctcca gctgctcact tagcaaggtg
     4921 ccctccctac tcctgtgagc acgctccaac cttgcctcca actgtaccta ccccatccaa
     4981 atgggcttgg tcagcctgag tcaacaagca gaacaagtca ctgagtggca atgtcacgac
     5041 tttatttatg gtgcctgtgc tttgtctcaa aaataccttc tcctcctccc cagacaatag
     5101 gtggggagga ggcagcaaaa atagaacatc cctccctatt gcacatggac cctatataca
     5161 ggcccacctg gcagaggcca gtgggactct tggcacattc ctggtccctg ctggggaggg
     5221 ggggaggagt gctgggtagc atcacacgtg aggtgggacc ctggggcaac cactctgctt
     5281 ctggatactt atctttgcat ttcttggtcc ttgtttcctt cttggtccca tctctgatgc
     5341 tcagagcaac atctcagcaa catctcccta cctggctcag cctcccacct ctatcctgac
     5401 ctcagagaac cccttggttc ctggggactc tgtgctttcc tcccggttct gaggtcccga
     5461 gaggttatgg cttctcagca acttccccca gagccttgtc actcatgttc acgcggggga
     5521 aagggtgcgt gtgtcagaag cagcagtata aatatggtgc ggg
//
LOCUS       NM_001437578            5421 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 5, mRNA.
ACCESSION   NM_001437578 XM_063265611
VERSION     NM_001437578.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5421)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5421)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5421)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5421)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5421)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5421)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5421)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5421)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5421)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5421)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063265611.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2714.1,
                                           SRR26643293.3537.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-311             JAXUCZ010000001.1  130337632-130337825 c
            312-515             JAXUCZ010000001.1  130317243-130317446 c
            516-653             JAXUCZ010000001.1  130292969-130293106 c
            654-873             JAXUCZ010000001.1  130290825-130291044 c
            874-933             JAXUCZ010000001.1  130289823-130289882 c
            934-1121            JAXUCZ010000001.1  130277028-130277215 c
            1122-1248           JAXUCZ010000001.1  130267560-130267686 c
            1249-1375           JAXUCZ010000001.1  130263566-130263692 c
            1376-5421           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5421
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..311
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             258..1745
                     /gene="Mef2a"
                     /note="isoform 3 is encoded by transcript variant 5;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 3"
                     /protein_id="NP_001424507.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPD
                     TSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPG
                     SSLVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPN
                     GAGNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVV
                     IPPSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSL
                     TSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNI
                     NIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSS
                     SSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="Phosphoserine, by CK2. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     phosphorylation site"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    546..719
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    546..719
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    549..551
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    <642..>1373
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <642..>1373
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    780..932
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    894..899
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     misc_feature    960..962
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    981..1070
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1002..1004
                     /gene="Mef2a"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1020..1022
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1053..1106
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Required for interaction with MAPKs.
                     /evidence=ECO:0000250"
     misc_feature    1167..1169
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1188..1190
                     /gene="Mef2a"
                     /note="Phosphothreonine, by MAPK7 and MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1296..1298
                     /gene="Mef2a"
                     /note="Phosphoserine, by MAPK7.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1401..1742
                     /gene="Mef2a"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MJT0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1440..1442
                     /gene="Mef2a"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); acetylation site"
     misc_feature    1455..1457
                     /gene="Mef2a"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000269|PubMed:16484498; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1476..1478
                     /gene="Mef2a"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q60929; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1578..1580
                     /gene="Mef2a"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q02078; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); phosphorylation site"
     misc_feature    1617..1622
                     /gene="Mef2a"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q2MJT0.1); cleavage site"
     exon            312..515
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            516..653
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            654..873
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            874..933
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1121
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1248
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1375
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..5421
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcgatt
      121 tttaagacaa tttcagcggc agccttggac tggaaggtta aataatagga actgtgtacg
      181 atgcattagg atattgaaga aaattagctt ctgaattaat tatttggaat ataaggaaga
      241 aaaggtgact tttgaaaatg gggcgaaaga aaatacaaat tacacgcata atggatgaga
      301 ggaaccgaca ggtgactttt acaaagcgaa agttcggatt gatgaagaaa gcctatgaac
      361 tcagtgtgct ctgtgactgt gagatagcac tcatcatctt caacagctct aacaagttgt
      421 ttcagtacgc cagcactgac atggacaaag tccttctcaa gtacaccgag tacaacgagc
      481 ctcatgaaag caggacgaac tcggatattg tggaggctct gaacaagaag gaacacagag
      541 gctgcgacag cccagaccct gatacttcat atgtgctaac tccacataca gaagaaaaat
      601 ataaaaaaat taatgaggaa tttgataata tgatgcggaa tcataaaatc gcacctggct
      661 tgccgcctca gaacttctca atgtctgtca cagtccctgt gaccagccct aatgctttgt
      721 cgtacactaa cccagggagt tcactcgtgt caccgtcttt ggcagccagc tcaacattag
      781 cagagtccag catgctgtct ccacccccag ccacgctaca tagaaatgtg tctccaggag
      841 ctccgcagag accaccaagc actggcagtg caggtgggat gttgagcact acagacctca
      901 cggtaccaaa tggagctgga aatagtcctg tggggaatgg atttgtaaac tcaagggcct
      961 ctccaaattt gattggaaat actggtgcga atagtgtagg caaagtcatg cctacaaagt
     1021 cccccccgcc accaggtggg ggcagtgttg gaatgaacag tcggaaacca gatctacggg
     1081 ttgtcattcc cccttcaagc aagggcatga tgcccccact taatgcccaa aggataagta
     1141 gttctcaagc cacacaacct cttgccacgc ccgtggtgtc tgtgacaact ccaagcttgc
     1201 ctccgcaggg actagtgtac tcggccatgc cgacagccta caacactgat tactcattga
     1261 ccagcgctga cctgtccgcc ctgcaaggct ttacttcccc tggaatgctg tctctggggc
     1321 aggcttcagc ctggcagcag caccatctag gacaagcggc cctcagctct ctagtggctg
     1381 gagggcagtt atctcagggt tcaaatttgt ccattaacac caaccagaac atcaacatta
     1441 agtcagagcc aatttcacct ccccgtgata gaatgacccc atcaggcttc cagcagcagc
     1501 agcagcagca gccacagcag caaccaccgc cacaacctcc acagccccag ccccaacccc
     1561 ggcaggaaat ggggcgctcc cctgtggaca gtctgagcag ctctagcagc tcctacgatg
     1621 gcagtgaccg ggaggatcca cggggcgact tccattctcc aattgtgctt ggccgacctc
     1681 caaatgctga ggacagagaa agcccctctg taaaacgcat gaggatggac acatgggtga
     1741 cctaaggctt cctggttcat gtctgttctt tgtgttactg cagtgaactg ccctacatat
     1801 cttaaattgg tgaataagga catgagttca atatatttat atgtacatgc atacatatat
     1861 atccctttac atatatatgt atgtcggtgt gagtgtgtgt atgtgtgggt gtgtgttgca
     1921 tacacagaat caggcactta ctgcgactcc ttgtaggtat gcagatgtgt gcacacggca
     1981 cacagagcac cttgtagaga cagaccagcc tggcacttcc ttggactact tgtctcctaa
     2041 gataaagttt ttgcagagaa acgtgtaccc atatataatt cttccacatt agcctgcaga
     2101 aacctagggg cccctatttg ttttatttac ctgtgcggtg actgtagtta cttcaaaaaa
     2161 aaaaaaaatt gctttgtaga acagagcagt agaaaagcag gaaccaagaa agcaatactg
     2221 tacataaagt catttatatt aataacccaa cctggcatgg gtctattgca gaggggtgca
     2281 tgggcaaggg ctgtctatat taaacagaca cagtaaacaa agagccccac acataactgt
     2341 tttgcacgtg caaaaaaatg tattgggtca aagaagtgat ttttagctat taaaaagaga
     2401 gaatagaaaa cacgcatgaa atattcagaa atactagcct agaaatatag agcattaaca
     2461 aaataaaatt aatatattaa gttataattg gaatatgtca gaagtttctt ttacattcat
     2521 atctttaaaa attaaagaaa ctgattttag gtcatgtata ttttatatga aagaaaacac
     2581 ccttaatgaa ttgatgacta tatataaaat tatatccact acttttgaac acattctgct
     2641 gaattattta tataagccaa agctgtatgt tgtaactttt ttttttaaag aatagcttta
     2701 tcttgtttta actttttagt tttattttaa gagggaagaa aaaaacaaaa atatcttgca
     2761 agcagaacct tggaaaaaaa aaagccatga acattattat tctatatgta aattaaaagt
     2821 cgagccaaac tctttgtgta tatagcatct taaatatatt accacctttg atgtaagtac
     2881 ctatgtattg tatggtcacc agattaaaaa gtatattttt gtggattgcc accaatttgg
     2941 ggggaaaggc gaagtcctta agtagagtat tcactgttta atatttacta ttttgttaaa
     3001 tatactgtac tttggatttt aattattagc ccagtttttc agaggattgt gtaaaggggt
     3061 ttcccctcac tggtggtgaa tgtgtgatgt tctgttgtaa tctttgtgct gtatggggtg
     3121 agcatcatta tatattttat atgtgtacat aaatagcaaa gtggcaaaaa aattggtgtt
     3181 aagttcatcc tgcataaata taaaatgtgt tgtaacagat tttataaggc attatttaaa
     3241 acttgccttt tgtgagggaa aaaaaaaaac agtagaaaga tgacctaatt taactaatat
     3301 tagagaaaat ggctgagtag tagatgagca caaaggtttt ataagtggta aataattagg
     3361 aaaatatttg taggggaagg gatcttttct ccttgactct aaagatagaa tgatgcagct
     3421 ggttacaaaa tccaggaggg ctttagcgtc ccgtgcgtgg gaaggcacgg gcgtgcaggg
     3481 agcagctctc ctatggtgca gatccccgac acaattcttg ctgtcctgac ggaaactggt
     3541 gccaccctca gcttggattt tgaacaaggc cttactctta cagggagaca gctcgttggt
     3601 gatggcaagt tcatccgttt actgggcttg tgccatgaac aaaattcaaa gtcctgtata
     3661 tcttttatcc tagattttta aatactcctt ttcctgaaaa aacttaaaga gtttaaaaat
     3721 ggctgctatt ttatactgaa caatgttgag cagctacctg cagtttttac ttacattttg
     3781 cttttcccct cgattcccta aattatgctc cttttgatgt ctcctcatct gctgtcccga
     3841 cagctcatca gccaggtttc ctgcctggcc gcacacaggt attcggtcca tgcaccgtgg
     3901 tgagcacagg ctgtgcactg gagagcctca ctgacagtct gggtagcaca tgttagtgga
     3961 agccaaggaa gtggggacgg tgtctcatct cctctgtggt ctcagcactt ggctcttcct
     4021 cagagaaggt taggttttct tcctcaagtg tactgagttg acttacaggc acgttcctca
     4081 taaggtcaca gtctcccaac actgactttc caagataccc cttaccactt tgtaaaccat
     4141 ttatagcttt gaaagtatta agtgaccctt tcattattat ttatgcatgt tcatgaactt
     4201 ctgctgtata ttgggatagg agttaacaca ttcacattta ctgtctattt tcttgtgtgc
     4261 cttatgagat ggcttctctg actgtatctc aatagtcttt ctatgcaggt ttataatcag
     4321 tacaactact gttttctaaa ggaatattac acacggctcg gagtttgtac ttaaattaca
     4381 ctgaccaagt cacaatgtat tccgttttca ggaactgaat atctgactgt taatcttttc
     4441 ccatatgccc agtgtgatct ggagcatatg ggtctgacat ccttcaccca gatgctcatg
     4501 tgtgaacaca tccacatcca cagctctcag tggaagccag cctagagtag ggaggacact
     4561 gacggtgttg ctttaaactg acttttctta ccctttgaga ctcatgtgtt ttgtataaga
     4621 caccatcaca agaaagtttt ctcccttcag ataacatatt ttattattaa aaagaaaaac
     4681 aaaaaaagct tttaagttgc actggacgtg ggccgttcct tcggaactct ttggatctac
     4741 actgagagtg agtgtcgccg ctctgtgaac acaggtggtc ccagtcaaaa ctccatcctt
     4801 tgagccctaa ttacatccat tgtgttacaa aactaaatca ggggtttgtt ctaaaagaac
     4861 aatacatgtc tcaccatttc ctttcaactg taaagacgac tgataatgta ttaacataat
     4921 ttctgtatta accatcatgc gcacaagaaa tacatagtaa atacggaacc tgaaaactcc
     4981 tgcatcggat cataaaagct agatgattag aatgtgaaaa gaactttaca gatgtaaaac
     5041 ttttatttct ctgtagaaac tttcttcact ttgctgtgca agaagacact gctttgctat
     5101 atttaaaatg gcttttttaa aaagagattt atgtatttgg taaatgtttg tagtcaacag
     5161 ttcacacaaa gaagctgtac acggtttgat catgtaaaac cgtttggcgg cacaagctgg
     5221 actttgttgc catccttgag atgaaccttt taagaaaaat aagttaatct caatttttcc
     5281 ctgaatgtgt tgttttttct tcattataca ataaatatta tagtgaagtt tttatcaaat
     5341 ggttaagaca atgctagagg ttgttgtaag ctatttgtct cctgcactca ctccagtaaa
     5401 gatggcctgg ctttgaccat a
//
LOCUS       NM_001437577            5439 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 3, mRNA.
ACCESSION   NM_001437577 XM_063265595
VERSION     NM_001437577.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5439)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5439)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5439)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5439)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5439)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5439)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5439)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5439)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5439)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5439)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063265595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.1885.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-311             JAXUCZ010000001.1  130337632-130337825 c
            312-515             JAXUCZ010000001.1  130317243-130317446 c
            516-647             JAXUCZ010000001.1  130293170-130293301 c
            648-867             JAXUCZ010000001.1  130290825-130291044 c
            868-927             JAXUCZ010000001.1  130289823-130289882 c
            928-1115            JAXUCZ010000001.1  130277028-130277215 c
            1116-1139           JAXUCZ010000001.1  130271166-130271189 c
            1140-1266           JAXUCZ010000001.1  130267560-130267686 c
            1267-1393           JAXUCZ010000001.1  130263566-130263692 c
            1394-5439           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5439
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..311
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             258..1763
                     /gene="Mef2a"
                     /note="isoform 2 is encoded by transcript variant 3;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 2"
                     /protein_id="NP_001424506.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIP
                     PSSKGMMPPLSEEEELELNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAY
                     NTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSI
                     NTNQNINIKSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVD
                     SLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    258..>962
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    258..>962
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    261..491
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(261..269,273..275,279..281,294..296,300..302,
                     312..317,324..329,333..338,345..350,354..359,369..371)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(318..320,339..344,351..356,360..365,372..374,
                     387..389,393..395,399..401,417..419,423..425,441..443,
                     450..455,462..464,471..476)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    432..434
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    <630..>1391
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <630..>1391
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            312..515
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            516..647
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            648..867
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            868..927
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1115
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1139
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1266
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1393
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..5439
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcgatt
      121 tttaagacaa tttcagcggc agccttggac tggaaggtta aataatagga actgtgtacg
      181 atgcattagg atattgaaga aaattagctt ctgaattaat tatttggaat ataaggaaga
      241 aaaggtgact tttgaaaatg gggcgaaaga aaatacaaat tacacgcata atggatgaga
      301 ggaaccgaca ggtgactttt acaaagcgaa agttcggatt gatgaagaaa gcctatgaac
      361 tcagtgtgct ctgtgactgt gagatagcac tcatcatctt caacagctct aacaagttgt
      421 ttcagtacgc cagcactgac atggacaaag tccttctcaa gtacaccgag tacaacgagc
      481 ctcatgaaag caggacgaac tcggatattg tggagacttt aagaaagaaa ggccttaatg
      541 gttgtgagag ccctgatgct gacgattact ttgagcacag tccactctcg gaggacagat
      601 tcagcaaact aaatgaagat agtgatttta ttttcaaacg aggccctcct ggcttgccgc
      661 ctcagaactt ctcaatgtct gtcacagtcc ctgtgaccag ccctaatgct ttgtcgtaca
      721 ctaacccagg gagttcactc gtgtcaccgt ctttggcagc cagctcaaca ttagcagagt
      781 ccagcatgct gtctccaccc ccagccacgc tacatagaaa tgtgtctcca ggagctccgc
      841 agagaccacc aagcactggc agtgcaggtg ggatgttgag cactacagac ctcacggtac
      901 caaatggagc tggaaatagt cctgtgggga atggatttgt aaactcaagg gcctctccaa
      961 atttgattgg aaatactggt gcgaatagtg taggcaaagt catgcctaca aagtcccccc
     1021 cgccaccagg tgggggcagt gttggaatga acagtcggaa accagatcta cgggttgtca
     1081 ttcccccttc aagcaagggc atgatgcccc cactttcgga ggaagaggag ttggagctga
     1141 atgcccaaag gataagtagt tctcaagcca cacaacctct tgccacgccc gtggtgtctg
     1201 tgacaactcc aagcttgcct ccgcagggac tagtgtactc ggccatgccg acagcctaca
     1261 acactgatta ctcattgacc agcgctgacc tgtccgccct gcaaggcttt acttcccctg
     1321 gaatgctgtc tctggggcag gcttcagcct ggcagcagca ccatctagga caagcggccc
     1381 tcagctctct agtggctgga gggcagttat ctcagggttc aaatttgtcc attaacacca
     1441 accagaacat caacattaag tcagagccaa tttcacctcc ccgtgataga atgaccccat
     1501 caggcttcca gcagcagcag cagcagcagc cacagcagca accaccgcca caacctccac
     1561 agccccagcc ccaaccccgg caggaaatgg ggcgctcccc tgtggacagt ctgagcagct
     1621 ctagcagctc ctacgatggc agtgaccggg aggatccacg gggcgacttc cattctccaa
     1681 ttgtgcttgg ccgacctcca aatgctgagg acagagaaag cccctctgta aaacgcatga
     1741 ggatggacac atgggtgacc taaggcttcc tggttcatgt ctgttctttg tgttactgca
     1801 gtgaactgcc ctacatatct taaattggtg aataaggaca tgagttcaat atatttatat
     1861 gtacatgcat acatatatat ccctttacat atatatgtat gtcggtgtga gtgtgtgtat
     1921 gtgtgggtgt gtgttgcata cacagaatca ggcacttact gcgactcctt gtaggtatgc
     1981 agatgtgtgc acacggcaca cagagcacct tgtagagaca gaccagcctg gcacttcctt
     2041 ggactacttg tctcctaaga taaagttttt gcagagaaac gtgtacccat atataattct
     2101 tccacattag cctgcagaaa cctaggggcc cctatttgtt ttatttacct gtgcggtgac
     2161 tgtagttact tcaaaaaaaa aaaaaattgc tttgtagaac agagcagtag aaaagcagga
     2221 accaagaaag caatactgta cataaagtca tttatattaa taacccaacc tggcatgggt
     2281 ctattgcaga ggggtgcatg ggcaagggct gtctatatta aacagacaca gtaaacaaag
     2341 agccccacac ataactgttt tgcacgtgca aaaaaatgta ttgggtcaaa gaagtgattt
     2401 ttagctatta aaaagagaga atagaaaaca cgcatgaaat attcagaaat actagcctag
     2461 aaatatagag cattaacaaa ataaaattaa tatattaagt tataattgga atatgtcaga
     2521 agtttctttt acattcatat ctttaaaaat taaagaaact gattttaggt catgtatatt
     2581 ttatatgaaa gaaaacaccc ttaatgaatt gatgactata tataaaatta tatccactac
     2641 ttttgaacac attctgctga attatttata taagccaaag ctgtatgttg taactttttt
     2701 ttttaaagaa tagctttatc ttgttttaac tttttagttt tattttaaga gggaagaaaa
     2761 aaacaaaaat atcttgcaag cagaaccttg gaaaaaaaaa agccatgaac attattattc
     2821 tatatgtaaa ttaaaagtcg agccaaactc tttgtgtata tagcatctta aatatattac
     2881 cacctttgat gtaagtacct atgtattgta tggtcaccag attaaaaagt atatttttgt
     2941 ggattgccac caatttgggg ggaaaggcga agtccttaag tagagtattc actgtttaat
     3001 atttactatt ttgttaaata tactgtactt tggattttaa ttattagccc agtttttcag
     3061 aggattgtgt aaaggggttt cccctcactg gtggtgaatg tgtgatgttc tgttgtaatc
     3121 tttgtgctgt atggggtgag catcattata tattttatat gtgtacataa atagcaaagt
     3181 ggcaaaaaaa ttggtgttaa gttcatcctg cataaatata aaatgtgttg taacagattt
     3241 tataaggcat tatttaaaac ttgccttttg tgagggaaaa aaaaaaacag tagaaagatg
     3301 acctaattta actaatatta gagaaaatgg ctgagtagta gatgagcaca aaggttttat
     3361 aagtggtaaa taattaggaa aatatttgta ggggaaggga tcttttctcc ttgactctaa
     3421 agatagaatg atgcagctgg ttacaaaatc caggagggct ttagcgtccc gtgcgtggga
     3481 aggcacgggc gtgcagggag cagctctcct atggtgcaga tccccgacac aattcttgct
     3541 gtcctgacgg aaactggtgc caccctcagc ttggattttg aacaaggcct tactcttaca
     3601 gggagacagc tcgttggtga tggcaagttc atccgtttac tgggcttgtg ccatgaacaa
     3661 aattcaaagt cctgtatatc ttttatccta gatttttaaa tactcctttt cctgaaaaaa
     3721 cttaaagagt ttaaaaatgg ctgctatttt atactgaaca atgttgagca gctacctgca
     3781 gtttttactt acattttgct tttcccctcg attccctaaa ttatgctcct tttgatgtct
     3841 cctcatctgc tgtcccgaca gctcatcagc caggtttcct gcctggccgc acacaggtat
     3901 tcggtccatg caccgtggtg agcacaggct gtgcactgga gagcctcact gacagtctgg
     3961 gtagcacatg ttagtggaag ccaaggaagt ggggacggtg tctcatctcc tctgtggtct
     4021 cagcacttgg ctcttcctca gagaaggtta ggttttcttc ctcaagtgta ctgagttgac
     4081 ttacaggcac gttcctcata aggtcacagt ctcccaacac tgactttcca agatacccct
     4141 taccactttg taaaccattt atagctttga aagtattaag tgaccctttc attattattt
     4201 atgcatgttc atgaacttct gctgtatatt gggataggag ttaacacatt cacatttact
     4261 gtctattttc ttgtgtgcct tatgagatgg cttctctgac tgtatctcaa tagtctttct
     4321 atgcaggttt ataatcagta caactactgt tttctaaagg aatattacac acggctcgga
     4381 gtttgtactt aaattacact gaccaagtca caatgtattc cgttttcagg aactgaatat
     4441 ctgactgtta atcttttccc atatgcccag tgtgatctgg agcatatggg tctgacatcc
     4501 ttcacccaga tgctcatgtg tgaacacatc cacatccaca gctctcagtg gaagccagcc
     4561 tagagtaggg aggacactga cggtgttgct ttaaactgac ttttcttacc ctttgagact
     4621 catgtgtttt gtataagaca ccatcacaag aaagttttct cccttcagat aacatatttt
     4681 attattaaaa agaaaaacaa aaaaagcttt taagttgcac tggacgtggg ccgttccttc
     4741 ggaactcttt ggatctacac tgagagtgag tgtcgccgct ctgtgaacac aggtggtccc
     4801 agtcaaaact ccatcctttg agccctaatt acatccattg tgttacaaaa ctaaatcagg
     4861 ggtttgttct aaaagaacaa tacatgtctc accatttcct ttcaactgta aagacgactg
     4921 ataatgtatt aacataattt ctgtattaac catcatgcgc acaagaaata catagtaaat
     4981 acggaacctg aaaactcctg catcggatca taaaagctag atgattagaa tgtgaaaaga
     5041 actttacaga tgtaaaactt ttatttctct gtagaaactt tcttcacttt gctgtgcaag
     5101 aagacactgc tttgctatat ttaaaatggc ttttttaaaa agagatttat gtatttggta
     5161 aatgtttgta gtcaacagtt cacacaaaga agctgtacac ggtttgatca tgtaaaaccg
     5221 tttggcggca caagctggac tttgttgcca tccttgagat gaacctttta agaaaaataa
     5281 gttaatctca atttttccct gaatgtgttg ttttttcttc attatacaat aaatattata
     5341 gtgaagtttt tatcaaatgg ttaagacaat gctagaggtt gttgtaagct atttgtctcc
     5401 tgcactcact ccagtaaaga tggcctggct ttgaccata
//
LOCUS       NM_001437555            4303 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 7, mRNA.
ACCESSION   NM_001437555 XM_063287211
VERSION     NM_001437555.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4303)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287211.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1822835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3712           JAXUCZ010000001.1  254865878-254866015
            3713-3779           JAXUCZ010000001.1  254866108-254866174
            3780-3901           JAXUCZ010000001.1  254866293-254866414
            3902-4053           JAXUCZ010000001.1  254866843-254866994
            4054-4303           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..4303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4303
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4157
                     /gene="Pprc1"
                     /note="isoform 7 is encoded by transcript variant 7;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 7"
                     /protein_id="NP_001424484.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSSCSSSGRSRRCSSSSSSSSSS
                     SSSSSSRSRSPSVSPCRRSDRRRRYSSYRSNDHYQRQRVLQKERAIEERRVVFIGKIP
                     GRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADE
                     QPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3783..4055
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    3783..4055
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3712
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3779
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3901
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4053
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4303
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact cagggtccag ctgcagttcc tctggacggt
     3601 ccagaagatg ttcctcctct tcctcttctt cctcctcctc atcttcatca tccagttcca
     3661 gaagccggtc tccctctgtg tccccttgca ggagaagtga ccggaggcgg cggtacagct
     3721 cttaccgttc aaatgaccat taccaaaggc agagagtact gcagaaggag cgtgcaatag
     3781 aagagagaag ggtggtcttc attgggaaaa tacctggccg catgactcgg tcggagctga
     3841 agcagaggtt ctctgttttt ggagagattg aggagtgtac cattcatttt cgtgtccaag
     3901 gtgacaacta tggtttcgtc acttaccggt atgctgaaga ggcatttgca gccattgaga
     3961 gtggccacaa gttgcggcag gcagacgagc agccctttga tctctgcttt gggggccgaa
     4021 ggcagttctg caagaggagt tactctgatc ttgactccaa tcgggaagac tttgatcctg
     4081 ctcctgtcaa gagcaaattc gattctcttg actttgatac tttgttgaaa caggcccaga
     4141 agaacctaag gaggtaaccc tgggctttcc tcccccatcc attttctctg gaggtgtcca
     4201 acctctcaac cccctcccct actctagggg agagagctgc tagtgtggaa agacttttat
     4261 aaggaaatga aaaaaagtta aataaaaata tgttaaatcg gga
//
LOCUS       NM_001437596             659 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus CDC42 effector protein 5 (Cdc42ep5), transcript
            variant 3, mRNA.
ACCESSION   NM_001437596
VERSION     NM_001437596.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 659)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   2  (bases 1 to 659)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW918408.1, CB793038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  79108783-79108845
            64-659              JAXUCZ010000001.1  79109955-79110550
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..659
                     /gene="Cdc42ep5"
                     /note="CDC42 effector protein 5"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
     exon            1..63
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..525
                     /gene="Cdc42ep5"
                     /note="isoform 2 is encoded by transcript variant 3; CDC42
                     effector protein (Rho GTPase binding) 5"
                     /codon_start=1
                     /product="cdc42 effector protein 5 isoform 2"
                     /protein_id="NP_001424525.1"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
                     /translation="MPRSWNPYQMALLKQVGPAQPKKRLERGALSISAPLGDFRHTLH
                     VGSSGDAFGDTSFLNRHGGGPPPEAGAPPVVAPHSVPPPAVPQASVPGLRVPSPADPL
                     LSFHLDLGPSMLDAVLGVMDAERGETTATKPSGDALTGMQHPNAHCCSNADFQLDDVI
                     GL"
     misc_feature    130..>213
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    130..>213
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    <271..402
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
     misc_feature    <271..402
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
     exon            64..659
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggaccca gcgtgcagcg gtggcactca ggccacatgc ctaggtcctg gaacccctac
       61 cagatggcgt tgttgaagca ggtgggccct gcacagccaa agaagcgact ggagcgtgga
      121 gcactctcta tctcagcacc ccttggagac ttcaggcaca cattgcacgt gggaagcagt
      181 ggcgatgcct tcggagacac ctcattcctg aataggcacg ggggtggtcc acctccggag
      241 gctggagccc caccagttgt ggccccacat tctgtccctc cacctgcagt tccacaggcc
      301 tctgtgcctg gtctccgagt tccttcacct gcagacccgc tactgtcctt ccacctggac
      361 ctgggcccct ctatgctgga cgcagtgtta ggcgtcatgg acgcggagcg cggcgagacg
      421 acggccacca agcccagtgg ggatgccctc actggaatgc agcatcccaa tgcccactgc
      481 tgctccaatg ctgacttcca gctggatgat gtcattggtc tgtagtatct tgattcccgc
      541 aactcctccc tccctgcact ccacttttgt acacataaat agccgagttt tacgcgggaa
      601 ggggtgcaga agcaggacag tggtggggtg ccaccaacta aaagtcaaat ctgtcctca
//
LOCUS       NM_001437549            5095 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 1, mRNA.
ACCESSION   NM_001437549 XM_006231451
VERSION     NM_001437549.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006231451.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.5498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-506             JAXUCZ010000001.1  254856941-254857090
            507-608             JAXUCZ010000001.1  254857203-254857304
            609-3465            JAXUCZ010000001.1  254857400-254860256
            3466-3519           JAXUCZ010000001.1  254860529-254860582
            3520-3577           JAXUCZ010000001.1  254861917-254861974
            3578-3648           JAXUCZ010000001.1  254862692-254862762
            3649-4366           JAXUCZ010000001.1  254863590-254864307
            4367-4504           JAXUCZ010000001.1  254865878-254866015
            4505-4571           JAXUCZ010000001.1  254866108-254866174
            4572-4693           JAXUCZ010000001.1  254866293-254866414
            4694-4845           JAXUCZ010000001.1  254866843-254866994
            4846-5095           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5095
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4949
                     /gene="Pprc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 1"
                     /protein_id="NP_001424478.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGEQSRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSL
                     HKLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKL
                     PSWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACP
                     EEEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTL
                     PEGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPG
                     TEDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRK
                     KKKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRG
                     KPRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDS
                     ARADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAV
                     AIPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRP
                     SLEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAED
                     RNSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVS
                     PTPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSL
                     PPLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGY
                     SCLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPP
                     FWSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPA
                     EPTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENR
                     PREKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIG
                     IEASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGSIDTPQEKKPLDRLHAPELAN
                     VAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEG
                     VRGPSPVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSA
                     APPLPCTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDK
                     QRSMRCYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRS
                     LSPPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYS
                     SYRSNDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFR
                     VQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNRE
                     DFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1164..2561
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1164..2561
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1920..3377
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1920..3377
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2961..4115
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2961..4115
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4575..4847
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4575..4847
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..506
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..608
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..3465
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3519
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3577
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3648
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..4366
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4504
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4571
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4693
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4694..4845
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..5095
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagcaga
      361 gcaggctatc tttggaggac cagaatgaga tgtcgctgct cacagctctg acggagatct
      421 tggacaatgc agattctgag aacctgtccc cgtttgatac cattcctgat tcagagctgc
      481 tcgtgtctcc tcgggagagc tcctctctgc acaagctgct caatctctct cggacacctc
      541 cagaacgtga ccgcatcccc gcaatggacc ctttggggcc cagcgcagga agtagtcggg
      601 tgagtggggt tgagatgtcc cttgcagatt ctccgtggga cttctctcca cctcctttct
      661 tggaaacttc ttcccctaag ctgcctagct ggagatcctc aagaccaaga cctcgatgga
      721 gtcagtctcc tcctccccag cagcgcagtg atggagagga ggaggaagag gttgccggct
      781 tcagtggtca gatgcttgat ggcgaacttg acaactcggt gaataccttg gatttcccca
      841 tgcacctggc atgccctgag gaagaagaca agtcaggggc agcaaatgtg gcagtgtcag
      901 cacctggtga cgagagcatc tcctccttga gtgagctggt acgggccatg cacccctact
      961 gcttacccaa cctcacccag ttggcatcac ttgacgctga gcttcaggag caggctgatg
     1021 atctgacact gcctgagggt tgtgtggtgc tggagattgt gggccaggca gccacagctg
     1081 gtgatgacct ggagatccca gtggtcgtgc ggcagattcc ttcaggatcc cagtctgtgc
     1141 tcctagatgg gtctgtaggg actgatcctg ccttgcagct actcatgccc gccatggagc
     1201 ctggaacaga agatggtgtg cctaaagtcg ctccttgccc tgatcaagaa ttaccactga
     1261 gctctgcctg cttattggag cccagggaca tcatggagtc attggccccc aaggagcctc
     1321 ggaacctacc tgccaatgca agtgagggtt ctcagagagt tcccagaaag ggtaggaaga
     1381 agaagaagaa ggagcagcca acagcctgtt tggaaggctg taccaggagg ctgaggtcat
     1441 cttctcgtgg acagtctact gtggctacag aggtgaactc tcaggcaggc aacttacaga
     1501 aacagcctca ggaagagctt cagagagaga ctgcggcccc tcagagcaga gggaagccac
     1561 gggcttgggc tcgggcctgg gcagctgcct tggagaaaac tgggtctgaa gacccagagg
     1621 accagaatgc aggacaggat agtcctgctg aggaagatgt tctagaactc cgtcctaagc
     1681 tggtggagac tagccaagcc gaccccacgc tctcactaaa cgactctgct cgagctgact
     1741 ccatcccagt taactctgtt gaaggtgact ccactgcagt ggacactgct gtacctgttg
     1801 accaggcttc atcttgtaca gagctggttg gttctctctc aggaggccca attctgagta
     1861 gcccagtcct agatgacagg acaggagttg aacctgcagt ggctattccc acttcaaatc
     1921 acttgtctcc agctgatgct atcctagcta acccagggac agctgaccct gctccaaatg
     1981 gcctggctcc aggagatcct gtgctagtta agtgcagacc aactgatcct agacgtgcag
     2041 ctgctgctgc cactgctgct caggggcctc gtccttccct agagccctca gaccatccta
     2101 aggtcatcac ccctgaagtc aaggatgctg gaggtcctct gaaggtggaa ggtagtacca
     2161 gtgctacaac ccaggaagcc agacctcggc ccctcagcct atctgagtac cgtcaacgac
     2221 ggcggcaacg gcaaatagaa gcagaagaca ggaattctca gcccccagct ggaaagtggc
     2281 caagtctccc agagacgccc aaagggctgg cagatatccc ttgtcttgtt ccatcagccc
     2341 caaccaagaa gacagcccca cagagaagcc ctatagctgt accagagact tgttctgtat
     2401 ctgtgggttc taaccctgtt tcccctactc ctgagccatc tgcaagcaaa cttatggttt
     2461 caactcactc tgaacaggtg tcatctcatg agatgccact tccagttaga cttccccctc
     2521 ctacattgca gtctatggct cctgctgggc ccaccccttc tacagtgccc acgccattgc
     2581 ctttccctcc gagcttacct cctctgcttc ctcttcctgc aagtggtcct ggtgtcccca
     2641 gcctgccccc acctcctttg caacctcctg gacttccagt atcaatgaga caaatgccac
     2701 ctgaccccta tactcagtat gcccctgtgc cgccctggcc ttgttacccc tctgtatctc
     2761 cttctggcta ttcttgtctg cccccaccac cagcgatgcc catagtgtcg ggtacccctg
     2821 gtacctatgc tgtaccccca acttgcaatg tgccttgggt accccctcct gcaccagtct
     2881 caccttatag ctccagctct gcctatgggt cccttgggtg gggcccaggg ttgcaacagc
     2941 ctcccttttg gtctactgtt tctccacctc cattgtcttc agcctctact ggtagagctg
     3001 ttcccccacc cagtgtggaa cccagtaaca gttcagctgg tcctccggaa gatacacttc
     3061 ctgtgccagt gaccccttcc ctgagctctc ggccagccag ccccatagct ccaccagcag
     3121 aacctacgaa gctggaggct cagccagtgc ctgtctctcc ccaaccgaaa cacaaagtgt
     3181 cccctgtggt acagagtccc cagatcaagg ttctaccaac tctgtctgct gagggcgtgg
     3241 ctattgggga atctgaatca gagaggctaa agccggagac ccaggagaac agaccaaggg
     3301 agaagcctat ctctacggct acgaaggctg ttctgttacc aaagcagagc actgtcgcaa
     3361 aactgcctgc cgtccatcca gcccggctaa ggaggctgtc cttcctgccc accccacgtg
     3421 ctcagggttc tgaggatgtg gtgcaggcat tcatcagtga gattgggatt gaagcatcag
     3481 acctgtccag tctgttggag cagtttgaga aatcagaagc caaaaaggag tgtcctctcc
     3541 cggctcctgc tgacagcgtg gctgtaggaa actcaggcag cattgacact ccccaggaga
     3601 agaaacccct agaccggtta cacgccccag aactggccaa cgtggcaggg ctcaccccgc
     3661 cagctacccc tccccaccag ttatggaaac ccctggctgc tgtctcactg ttggccaaag
     3721 ccaaatctcc taaatctact gcccaagagg gaaccctgaa gcctgaagga attacagagg
     3781 ccaaacctcc agctgcagcc tgcctccaag aaggggtccg tggccctagt ccagtccatg
     3841 tgggctctgg ggaccatgac tattgtgtcc gaagcaggac acccccaaaa aagatgcctg
     3901 ccctagtcat ttcagagatg ggctctcgat ggaatgtcaa gcgccatcag gacatcacta
     3961 tcaaacctgt cttgtcattg ggctcagctg cccccccact cccatgcaca accacttccc
     4021 aggaaccgct tgatcacagg actagcagtg agcaggcaga tccgtcagcg ccttgttttg
     4081 ccccatccac cttgctgtct cctgaggcct caccctgccg gaatgaaatg aacactagga
     4141 ctccctctga gcccccagac aagcagcggt caatgcgctg ttaccgaaaa gcctgcagat
     4201 cagccagccc cccaagtcgg ggctggcaag gccgccgtgg ccgtagcagc cgttctgtca
     4261 gctctgggtc cagccggacc agtgaagcat cctcatcctc atcggtgtct tcctcatccc
     4321 ggtcccggtc caggtccctc tcccccccaa acaagaggtg gcgaaggtcc agctgcagtt
     4381 cctctggacg gtccagaaga tgttcctcct cttcctcttc ttcctcctcc tcatcttcat
     4441 catccagttc cagaagccgg tctccctctg tgtccccttg caggagaagt gaccggaggc
     4501 ggcggtacag ctcttaccgt tcaaatgacc attaccaaag gcagagagta ctgcagaagg
     4561 agcgtgcaat agaagagaga agggtggtct tcattgggaa aatacctggc cgcatgactc
     4621 ggtcggagct gaagcagagg ttctctgttt ttggagagat tgaggagtgt accattcatt
     4681 ttcgtgtcca aggtgacaac tatggtttcg tcacttaccg gtatgctgaa gaggcatttg
     4741 cagccattga gagtggccac aagttgcggc aggcagacga gcagcccttt gatctctgct
     4801 ttgggggccg aaggcagttc tgcaagagga gttactctga tcttgactcc aatcgggaag
     4861 actttgatcc tgctcctgtc aagagcaaat tcgattctct tgactttgat actttgttga
     4921 aacaggccca gaagaaccta aggaggtaac cctgggcttt cctcccccat ccattttctc
     4981 tggaggtgtc caacctctca accccctccc ctactctagg ggagagagct gctagtgtgg
     5041 aaagactttt ataaggaaat gaaaaaaagt taaataaaaa tatgttaaat cggga
//
LOCUS       NM_001437583            5552 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 10, mRNA.
ACCESSION   NM_001437583
VERSION     NM_001437583.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5552)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5552)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5552)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5552)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5552)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5552)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5552)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5552)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5552)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5552)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1961.1,
                                           SRR26360186.1290007.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-170             JAXUCZ010000001.1  130365401-130365453 c
            171-364             JAXUCZ010000001.1  130337632-130337825 c
            365-442             JAXUCZ010000001.1  130322088-130322165 c
            443-646             JAXUCZ010000001.1  130317243-130317446 c
            647-784             JAXUCZ010000001.1  130292969-130293106 c
            785-1004            JAXUCZ010000001.1  130290825-130291044 c
            1005-1064           JAXUCZ010000001.1  130289823-130289882 c
            1065-1252           JAXUCZ010000001.1  130277028-130277215 c
            1253-1379           JAXUCZ010000001.1  130267560-130267686 c
            1380-1506           JAXUCZ010000001.1  130263566-130263692 c
            1507-5552           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5552
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..170
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..364
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            365..442
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    410..412
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     exon            443..646
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1876
                     /gene="Mef2a"
                     /note="isoform 5 is encoded by transcript variant 10;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 5"
                     /protein_id="NP_001424512.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEY
                     NEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHK
                     IAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLAESSMLSPPPATLH
                     RNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGAGNSPVGNGFVNSRASPNLIGNTGANS
                     VGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIPPSSKGMMPPLNAQRISSSQATQPLAT
                     PVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFTSPGMLSLGQASAWQQH
                     HLGQAALSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFQQQQQQQPQ
                     QQPPPQPPQPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNAE
                     DRESPSVKRMRMDTWVT"
     misc_feature    <473..622
                     /gene="Mef2a"
                     /note="MCM1, Agamous, Deficiens, and SRF (serum response
                     factor) box family of eukaryotic transcriptonal
                     regulators. Binds DNA and exists as hetero and
                     homo-dimers. Composed of 2 main subgroups: SRF-like/Type I
                     and MEF2-like (myocyte enhancer factor 2)/ Type...;
                     Region: MADS; cl00109"
                     /db_xref="CDD:469617"
     misc_feature    <473..622
                     /gene="Mef2a"
                     /note="MCM1, Agamous, Deficiens, and SRF (serum response
                     factor) box family of eukaryotic transcriptonal
                     regulators. Binds DNA and exists as hetero and
                     homo-dimers. Composed of 2 main subgroups: SRF-like/Type I
                     and MEF2-like (myocyte enhancer factor 2)/ Type...;
                     Region: MADS; cl00109"
                     /db_xref="CDD:469617"
     misc_feature    order(473..478,485..487,497..499,545..568)
                     /gene="Mef2a"
                     /note="protein interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238165"
     misc_feature    order(473..478,485..487,497..499,545..568)
                     /gene="Mef2a"
                     /note="protein interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238165"
     misc_feature    order(473..475,482..487,491..505,518..520,524..526,
                     530..532,548..550,554..556,560..562)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(473..475,482..487,491..505,518..520,524..526,
                     530..532,548..550,554..556,560..562)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    563..565
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    563..565
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    677..850
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    677..850
                     /gene="Mef2a"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:463543"
     misc_feature    <773..>1504
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <773..>1504
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            647..784
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1004
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1064
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1252
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1379
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1506
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..5552
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcggaa
      121 ttgcatcttg tggaaaagga acaaagaaga actttctgca aggataaaat atttttaaga
      181 caatttcagc ggcagccttg gactggaagg ttaaataata ggaactgtgt acgatgcatt
      241 aggatattga agaaaattag cttctgaatt aattatttgg aatataagga agaaaaggtg
      301 acttttgaaa atggggcgaa agaaaataca aattacacgc ataatggatg agaggaaccg
      361 acagcatcaa ccctttgtga tgtataactt caaacaaatg cttttgaaat gaattttggg
      421 aagagcagag aggctgagat gggtgacttt tacaaagcga aagttcggat tgatgaagaa
      481 agcctatgaa ctcagtgtgc tctgtgactg tgagatagca ctcatcatct tcaacagctc
      541 taacaagttg tttcagtacg ccagcactga catggacaaa gtccttctca agtacaccga
      601 gtacaacgag cctcatgaaa gcaggacgaa ctcggatatt gtggaggctc tgaacaagaa
      661 ggaacacaga ggctgcgaca gcccagaccc tgatacttca tatgtgctaa ctccacatac
      721 agaagaaaaa tataaaaaaa ttaatgagga atttgataat atgatgcgga atcataaaat
      781 cgcacctggc ttgccgcctc agaacttctc aatgtctgtc acagtccctg tgaccagccc
      841 taatgctttg tcgtacacta acccagggag ttcactcgtg tcaccgtctt tggcagccag
      901 ctcaacatta gcagagtcca gcatgctgtc tccaccccca gccacgctac atagaaatgt
      961 gtctccagga gctccgcaga gaccaccaag cactggcagt gcaggtggga tgttgagcac
     1021 tacagacctc acggtaccaa atggagctgg aaatagtcct gtggggaatg gatttgtaaa
     1081 ctcaagggcc tctccaaatt tgattggaaa tactggtgcg aatagtgtag gcaaagtcat
     1141 gcctacaaag tcccccccgc caccaggtgg gggcagtgtt ggaatgaaca gtcggaaacc
     1201 agatctacgg gttgtcattc ccccttcaag caagggcatg atgcccccac ttaatgccca
     1261 aaggataagt agttctcaag ccacacaacc tcttgccacg cccgtggtgt ctgtgacaac
     1321 tccaagcttg cctccgcagg gactagtgta ctcggccatg ccgacagcct acaacactga
     1381 ttactcattg accagcgctg acctgtccgc cctgcaaggc tttacttccc ctggaatgct
     1441 gtctctgggg caggcttcag cctggcagca gcaccatcta ggacaagcgg ccctcagctc
     1501 tctagtggct ggagggcagt tatctcaggg ttcaaatttg tccattaaca ccaaccagaa
     1561 catcaacatt aagtcagagc caatttcacc tccccgtgat agaatgaccc catcaggctt
     1621 ccagcagcag cagcagcagc agccacagca gcaaccaccg ccacaacctc cacagcccca
     1681 gccccaaccc cggcaggaaa tggggcgctc ccctgtggac agtctgagca gctctagcag
     1741 ctcctacgat ggcagtgacc gggaggatcc acggggcgac ttccattctc caattgtgct
     1801 tggccgacct ccaaatgctg aggacagaga aagcccctct gtaaaacgca tgaggatgga
     1861 cacatgggtg acctaaggct tcctggttca tgtctgttct ttgtgttact gcagtgaact
     1921 gccctacata tcttaaattg gtgaataagg acatgagttc aatatattta tatgtacatg
     1981 catacatata tatcccttta catatatatg tatgtcggtg tgagtgtgtg tatgtgtggg
     2041 tgtgtgttgc atacacagaa tcaggcactt actgcgactc cttgtaggta tgcagatgtg
     2101 tgcacacggc acacagagca ccttgtagag acagaccagc ctggcacttc cttggactac
     2161 ttgtctccta agataaagtt tttgcagaga aacgtgtacc catatataat tcttccacat
     2221 tagcctgcag aaacctaggg gcccctattt gttttattta cctgtgcggt gactgtagtt
     2281 acttcaaaaa aaaaaaaaat tgctttgtag aacagagcag tagaaaagca ggaaccaaga
     2341 aagcaatact gtacataaag tcatttatat taataaccca acctggcatg ggtctattgc
     2401 agaggggtgc atgggcaagg gctgtctata ttaaacagac acagtaaaca aagagcccca
     2461 cacataactg ttttgcacgt gcaaaaaaat gtattgggtc aaagaagtga tttttagcta
     2521 ttaaaaagag agaatagaaa acacgcatga aatattcaga aatactagcc tagaaatata
     2581 gagcattaac aaaataaaat taatatatta agttataatt ggaatatgtc agaagtttct
     2641 tttacattca tatctttaaa aattaaagaa actgatttta ggtcatgtat attttatatg
     2701 aaagaaaaca cccttaatga attgatgact atatataaaa ttatatccac tacttttgaa
     2761 cacattctgc tgaattattt atataagcca aagctgtatg ttgtaacttt tttttttaaa
     2821 gaatagcttt atcttgtttt aactttttag ttttatttta agagggaaga aaaaaacaaa
     2881 aatatcttgc aagcagaacc ttggaaaaaa aaaagccatg aacattatta ttctatatgt
     2941 aaattaaaag tcgagccaaa ctctttgtgt atatagcatc ttaaatatat taccaccttt
     3001 gatgtaagta cctatgtatt gtatggtcac cagattaaaa agtatatttt tgtggattgc
     3061 caccaatttg gggggaaagg cgaagtcctt aagtagagta ttcactgttt aatatttact
     3121 attttgttaa atatactgta ctttggattt taattattag cccagttttt cagaggattg
     3181 tgtaaagggg tttcccctca ctggtggtga atgtgtgatg ttctgttgta atctttgtgc
     3241 tgtatggggt gagcatcatt atatatttta tatgtgtaca taaatagcaa agtggcaaaa
     3301 aaattggtgt taagttcatc ctgcataaat ataaaatgtg ttgtaacaga ttttataagg
     3361 cattatttaa aacttgcctt ttgtgaggga aaaaaaaaaa cagtagaaag atgacctaat
     3421 ttaactaata ttagagaaaa tggctgagta gtagatgagc acaaaggttt tataagtggt
     3481 aaataattag gaaaatattt gtaggggaag ggatcttttc tccttgactc taaagataga
     3541 atgatgcagc tggttacaaa atccaggagg gctttagcgt cccgtgcgtg ggaaggcacg
     3601 ggcgtgcagg gagcagctct cctatggtgc agatccccga cacaattctt gctgtcctga
     3661 cggaaactgg tgccaccctc agcttggatt ttgaacaagg ccttactctt acagggagac
     3721 agctcgttgg tgatggcaag ttcatccgtt tactgggctt gtgccatgaa caaaattcaa
     3781 agtcctgtat atcttttatc ctagattttt aaatactcct tttcctgaaa aaacttaaag
     3841 agtttaaaaa tggctgctat tttatactga acaatgttga gcagctacct gcagttttta
     3901 cttacatttt gcttttcccc tcgattccct aaattatgct ccttttgatg tctcctcatc
     3961 tgctgtcccg acagctcatc agccaggttt cctgcctggc cgcacacagg tattcggtcc
     4021 atgcaccgtg gtgagcacag gctgtgcact ggagagcctc actgacagtc tgggtagcac
     4081 atgttagtgg aagccaagga agtggggacg gtgtctcatc tcctctgtgg tctcagcact
     4141 tggctcttcc tcagagaagg ttaggttttc ttcctcaagt gtactgagtt gacttacagg
     4201 cacgttcctc ataaggtcac agtctcccaa cactgacttt ccaagatacc ccttaccact
     4261 ttgtaaacca tttatagctt tgaaagtatt aagtgaccct ttcattatta tttatgcatg
     4321 ttcatgaact tctgctgtat attgggatag gagttaacac attcacattt actgtctatt
     4381 ttcttgtgtg ccttatgaga tggcttctct gactgtatct caatagtctt tctatgcagg
     4441 tttataatca gtacaactac tgttttctaa aggaatatta cacacggctc ggagtttgta
     4501 cttaaattac actgaccaag tcacaatgta ttccgttttc aggaactgaa tatctgactg
     4561 ttaatctttt cccatatgcc cagtgtgatc tggagcatat gggtctgaca tccttcaccc
     4621 agatgctcat gtgtgaacac atccacatcc acagctctca gtggaagcca gcctagagta
     4681 gggaggacac tgacggtgtt gctttaaact gacttttctt accctttgag actcatgtgt
     4741 tttgtataag acaccatcac aagaaagttt tctcccttca gataacatat tttattatta
     4801 aaaagaaaaa caaaaaaagc ttttaagttg cactggacgt gggccgttcc ttcggaactc
     4861 tttggatcta cactgagagt gagtgtcgcc gctctgtgaa cacaggtggt cccagtcaaa
     4921 actccatcct ttgagcccta attacatcca ttgtgttaca aaactaaatc aggggtttgt
     4981 tctaaaagaa caatacatgt ctcaccattt cctttcaact gtaaagacga ctgataatgt
     5041 attaacataa tttctgtatt aaccatcatg cgcacaagaa atacatagta aatacggaac
     5101 ctgaaaactc ctgcatcgga tcataaaagc tagatgatta gaatgtgaaa agaactttac
     5161 agatgtaaaa cttttatttc tctgtagaaa ctttcttcac tttgctgtgc aagaagacac
     5221 tgctttgcta tatttaaaat ggctttttta aaaagagatt tatgtatttg gtaaatgttt
     5281 gtagtcaaca gttcacacaa agaagctgta cacggtttga tcatgtaaaa ccgtttggcg
     5341 gcacaagctg gactttgttg ccatccttga gatgaacctt ttaagaaaaa taagttaatc
     5401 tcaatttttc cctgaatgtg ttgttttttc ttcattatac aataaatatt atagtgaagt
     5461 ttttatcaaa tggttaagac aatgctagag gttgttgtaa gctatttgtc tcctgcactc
     5521 actccagtaa agatggcctg gctttgacca ta
//
LOCUS       NM_001437582            5620 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 9, mRNA.
ACCESSION   NM_001437582 XM_039080843
VERSION     NM_001437582.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5620)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5620)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5620)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5620)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5620)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5620)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5620)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5620)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5620)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5620)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_039080843.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.2327466.1,
                                           SRR26360172.393950.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000001.1  130391566-130391834 c
            270-322             JAXUCZ010000001.1  130365401-130365453 c
            323-516             JAXUCZ010000001.1  130337632-130337825 c
            517-720             JAXUCZ010000001.1  130317243-130317446 c
            721-852             JAXUCZ010000001.1  130293170-130293301 c
            853-1072            JAXUCZ010000001.1  130290825-130291044 c
            1073-1132           JAXUCZ010000001.1  130289823-130289882 c
            1133-1320           JAXUCZ010000001.1  130277028-130277215 c
            1321-1447           JAXUCZ010000001.1  130267560-130267686 c
            1448-1574           JAXUCZ010000001.1  130263566-130263692 c
            1575-5620           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5620
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..269
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            270..322
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            323..516
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    451..453
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             463..1944
                     /gene="Mef2a"
                     /note="isoform 4 is encoded by transcript variant 9;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 4"
                     /protein_id="NP_001424511.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIP
                     PSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTS
                     ADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINI
                     KSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSSSS
                     YDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    463..>1167
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    463..>1167
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    466..696
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    466..696
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(466..474,478..480,484..486,499..501,505..507,
                     517..522,529..534,538..543,550..555,559..564,574..576)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(466..474,478..480,484..486,499..501,505..507,
                     517..522,529..534,538..543,550..555,559..564,574..576)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(523..525,544..549,556..561,565..570,577..579,
                     592..594,598..600,604..606,622..624,628..630,646..648,
                     655..660,667..669,676..681)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(523..525,544..549,556..561,565..570,577..579,
                     592..594,598..600,604..606,622..624,628..630,646..648,
                     655..660,667..669,676..681)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    637..639
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    637..639
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    <835..>1572
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <835..>1572
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            517..720
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            721..852
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1072
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1132
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1320
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1447
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1574
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..5620
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccgggg ggcggcgggc gcggcggcgg gggcccgccg gagccgtcgt gagtctcctc
       61 cctgggcgcg ccacctctgg ggccccccgc cgcgccgccc cgctcctccc tgaaagttga
      121 cggagttccc agggggctgc ggagccactc ggtccgttcc tccagcatcg cgaacctcgg
      181 ggtctccccg ttcggtagac agtcagtacg gggggcgtcc ggccctgtgg tcgcacttaa
      241 agttcccccg cttctgcttc gtggggaagg aattgcatct tgtggaaaag gaacaaagaa
      301 gaactttctg caaggataaa atatttttaa gacaatttca gcggcagcct tggactggaa
      361 ggttaaataa taggaactgt gtacgatgca ttaggatatt gaagaaaatt agcttctgaa
      421 ttaattattt ggaatataag gaagaaaagg tgacttttga aaatggggcg aaagaaaata
      481 caaattacac gcataatgga tgagaggaac cgacaggtga cttttacaaa gcgaaagttc
      541 ggattgatga agaaagccta tgaactcagt gtgctctgtg actgtgagat agcactcatc
      601 atcttcaaca gctctaacaa gttgtttcag tacgccagca ctgacatgga caaagtcctt
      661 ctcaagtaca ccgagtacaa cgagcctcat gaaagcagga cgaactcgga tattgtggag
      721 actttaagaa agaaaggcct taatggttgt gagagccctg atgctgacga ttactttgag
      781 cacagtccac tctcggagga cagattcagc aaactaaatg aagatagtga ttttattttc
      841 aaacgaggcc ctcctggctt gccgcctcag aacttctcaa tgtctgtcac agtccctgtg
      901 accagcccta atgctttgtc gtacactaac ccagggagtt cactcgtgtc accgtctttg
      961 gcagccagct caacattagc agagtccagc atgctgtctc cacccccagc cacgctacat
     1021 agaaatgtgt ctccaggagc tccgcagaga ccaccaagca ctggcagtgc aggtgggatg
     1081 ttgagcacta cagacctcac ggtaccaaat ggagctggaa atagtcctgt ggggaatgga
     1141 tttgtaaact caagggcctc tccaaatttg attggaaata ctggtgcgaa tagtgtaggc
     1201 aaagtcatgc ctacaaagtc ccccccgcca ccaggtgggg gcagtgttgg aatgaacagt
     1261 cggaaaccag atctacgggt tgtcattccc ccttcaagca agggcatgat gcccccactt
     1321 aatgcccaaa ggataagtag ttctcaagcc acacaacctc ttgccacgcc cgtggtgtct
     1381 gtgacaactc caagcttgcc tccgcaggga ctagtgtact cggccatgcc gacagcctac
     1441 aacactgatt actcattgac cagcgctgac ctgtccgccc tgcaaggctt tacttcccct
     1501 ggaatgctgt ctctggggca ggcttcagcc tggcagcagc accatctagg acaagcggcc
     1561 ctcagctctc tagtggctgg agggcagtta tctcagggtt caaatttgtc cattaacacc
     1621 aaccagaaca tcaacattaa gtcagagcca atttcacctc cccgtgatag aatgacccca
     1681 tcaggcttcc agcagcagca gcagcagcag ccacagcagc aaccaccgcc acaacctcca
     1741 cagccccagc cccaaccccg gcaggaaatg gggcgctccc ctgtggacag tctgagcagc
     1801 tctagcagct cctacgatgg cagtgaccgg gaggatccac ggggcgactt ccattctcca
     1861 attgtgcttg gccgacctcc aaatgctgag gacagagaaa gcccctctgt aaaacgcatg
     1921 aggatggaca catgggtgac ctaaggcttc ctggttcatg tctgttcttt gtgttactgc
     1981 agtgaactgc cctacatatc ttaaattggt gaataaggac atgagttcaa tatatttata
     2041 tgtacatgca tacatatata tccctttaca tatatatgta tgtcggtgtg agtgtgtgta
     2101 tgtgtgggtg tgtgttgcat acacagaatc aggcacttac tgcgactcct tgtaggtatg
     2161 cagatgtgtg cacacggcac acagagcacc ttgtagagac agaccagcct ggcacttcct
     2221 tggactactt gtctcctaag ataaagtttt tgcagagaaa cgtgtaccca tatataattc
     2281 ttccacatta gcctgcagaa acctaggggc ccctatttgt tttatttacc tgtgcggtga
     2341 ctgtagttac ttcaaaaaaa aaaaaaattg ctttgtagaa cagagcagta gaaaagcagg
     2401 aaccaagaaa gcaatactgt acataaagtc atttatatta ataacccaac ctggcatggg
     2461 tctattgcag aggggtgcat gggcaagggc tgtctatatt aaacagacac agtaaacaaa
     2521 gagccccaca cataactgtt ttgcacgtgc aaaaaaatgt attgggtcaa agaagtgatt
     2581 tttagctatt aaaaagagag aatagaaaac acgcatgaaa tattcagaaa tactagccta
     2641 gaaatataga gcattaacaa aataaaatta atatattaag ttataattgg aatatgtcag
     2701 aagtttcttt tacattcata tctttaaaaa ttaaagaaac tgattttagg tcatgtatat
     2761 tttatatgaa agaaaacacc cttaatgaat tgatgactat atataaaatt atatccacta
     2821 cttttgaaca cattctgctg aattatttat ataagccaaa gctgtatgtt gtaacttttt
     2881 tttttaaaga atagctttat cttgttttaa ctttttagtt ttattttaag agggaagaaa
     2941 aaaacaaaaa tatcttgcaa gcagaacctt ggaaaaaaaa aagccatgaa cattattatt
     3001 ctatatgtaa attaaaagtc gagccaaact ctttgtgtat atagcatctt aaatatatta
     3061 ccacctttga tgtaagtacc tatgtattgt atggtcacca gattaaaaag tatatttttg
     3121 tggattgcca ccaatttggg gggaaaggcg aagtccttaa gtagagtatt cactgtttaa
     3181 tatttactat tttgttaaat atactgtact ttggatttta attattagcc cagtttttca
     3241 gaggattgtg taaaggggtt tcccctcact ggtggtgaat gtgtgatgtt ctgttgtaat
     3301 ctttgtgctg tatggggtga gcatcattat atattttata tgtgtacata aatagcaaag
     3361 tggcaaaaaa attggtgtta agttcatcct gcataaatat aaaatgtgtt gtaacagatt
     3421 ttataaggca ttatttaaaa cttgcctttt gtgagggaaa aaaaaaaaca gtagaaagat
     3481 gacctaattt aactaatatt agagaaaatg gctgagtagt agatgagcac aaaggtttta
     3541 taagtggtaa ataattagga aaatatttgt aggggaaggg atcttttctc cttgactcta
     3601 aagatagaat gatgcagctg gttacaaaat ccaggagggc tttagcgtcc cgtgcgtggg
     3661 aaggcacggg cgtgcaggga gcagctctcc tatggtgcag atccccgaca caattcttgc
     3721 tgtcctgacg gaaactggtg ccaccctcag cttggatttt gaacaaggcc ttactcttac
     3781 agggagacag ctcgttggtg atggcaagtt catccgttta ctgggcttgt gccatgaaca
     3841 aaattcaaag tcctgtatat cttttatcct agatttttaa atactccttt tcctgaaaaa
     3901 acttaaagag tttaaaaatg gctgctattt tatactgaac aatgttgagc agctacctgc
     3961 agtttttact tacattttgc ttttcccctc gattccctaa attatgctcc ttttgatgtc
     4021 tcctcatctg ctgtcccgac agctcatcag ccaggtttcc tgcctggccg cacacaggta
     4081 ttcggtccat gcaccgtggt gagcacaggc tgtgcactgg agagcctcac tgacagtctg
     4141 ggtagcacat gttagtggaa gccaaggaag tggggacggt gtctcatctc ctctgtggtc
     4201 tcagcacttg gctcttcctc agagaaggtt aggttttctt cctcaagtgt actgagttga
     4261 cttacaggca cgttcctcat aaggtcacag tctcccaaca ctgactttcc aagatacccc
     4321 ttaccacttt gtaaaccatt tatagctttg aaagtattaa gtgacccttt cattattatt
     4381 tatgcatgtt catgaacttc tgctgtatat tgggatagga gttaacacat tcacatttac
     4441 tgtctatttt cttgtgtgcc ttatgagatg gcttctctga ctgtatctca atagtctttc
     4501 tatgcaggtt tataatcagt acaactactg ttttctaaag gaatattaca cacggctcgg
     4561 agtttgtact taaattacac tgaccaagtc acaatgtatt ccgttttcag gaactgaata
     4621 tctgactgtt aatcttttcc catatgccca gtgtgatctg gagcatatgg gtctgacatc
     4681 cttcacccag atgctcatgt gtgaacacat ccacatccac agctctcagt ggaagccagc
     4741 ctagagtagg gaggacactg acggtgttgc tttaaactga cttttcttac cctttgagac
     4801 tcatgtgttt tgtataagac accatcacaa gaaagttttc tcccttcaga taacatattt
     4861 tattattaaa aagaaaaaca aaaaaagctt ttaagttgca ctggacgtgg gccgttcctt
     4921 cggaactctt tggatctaca ctgagagtga gtgtcgccgc tctgtgaaca caggtggtcc
     4981 cagtcaaaac tccatccttt gagccctaat tacatccatt gtgttacaaa actaaatcag
     5041 gggtttgttc taaaagaaca atacatgtct caccatttcc tttcaactgt aaagacgact
     5101 gataatgtat taacataatt tctgtattaa ccatcatgcg cacaagaaat acatagtaaa
     5161 tacggaacct gaaaactcct gcatcggatc ataaaagcta gatgattaga atgtgaaaag
     5221 aactttacag atgtaaaact tttatttctc tgtagaaact ttcttcactt tgctgtgcaa
     5281 gaagacactg ctttgctata tttaaaatgg cttttttaaa aagagattta tgtatttggt
     5341 aaatgtttgt agtcaacagt tcacacaaag aagctgtaca cggtttgatc atgtaaaacc
     5401 gtttggcggc acaagctgga ctttgttgcc atccttgaga tgaacctttt aagaaaaata
     5461 agttaatctc aatttttccc tgaatgtgtt gttttttctt cattatacaa taaatattat
     5521 agtgaagttt ttatcaaatg gttaagacaa tgctagaggt tgttgtaagc tatttgtctc
     5581 ctgcactcac tccagtaaag atggcctggc tttgaccata
//
LOCUS       NM_001437559            5045 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 11, mRNA.
ACCESSION   NM_001437559
VERSION     NM_001437559.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5045)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2047303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000001.1  254851842-254851979
            139-312             JAXUCZ010000001.1  254856186-254856359
            313-459             JAXUCZ010000001.1  254856944-254857090
            460-561             JAXUCZ010000001.1  254857203-254857304
            562-3418            JAXUCZ010000001.1  254857400-254860256
            3419-3472           JAXUCZ010000001.1  254860529-254860582
            3473-3530           JAXUCZ010000001.1  254861917-254861974
            3531-3598           JAXUCZ010000001.1  254862695-254862762
            3599-4316           JAXUCZ010000001.1  254863590-254864307
            4317-4454           JAXUCZ010000001.1  254865878-254866015
            4455-4521           JAXUCZ010000001.1  254866108-254866174
            4522-4643           JAXUCZ010000001.1  254866293-254866414
            4644-4795           JAXUCZ010000001.1  254866843-254866994
            4796-5045           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5045
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..138
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..4899
                     /gene="Pprc1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 11"
                     /protein_id="NP_001424488.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MSTWLLSQAVGHLVSALEPHCRELGVSQPLPPSLACAGTSGLEV
                     HEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLISLIEDFGES
                     RLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLHKLLNLSRT
                     PPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLPSWRSSRPR
                     PRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPEEEDKSGAA
                     NVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLPEGCVVLEI
                     VGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGTEDGVPKVA
                     PCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKKKKKEQPTA
                     CLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGKPRAWARAW
                     AAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSARADSIPVN
                     SVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVAIPTSNHLS
                     PADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPSLEPSDHPK
                     VITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDRNSQPPAGK
                     WPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSPTPEPSASK
                     LMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLPPLLPLPAS
                     GPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYSCLPPPPAM
                     PIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPFWSTVSPPP
                     LSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAEPTKLEAQP
                     VPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRPREKPISTA
                     TKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGIEASDLSSL
                     LEQFEKSEAKKECPLPAPADSVAVGNSGIDTPQEKKPLDRLHAPELANVAGLTPPATP
                     PHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGVRGPSPVHVG
                     SGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAAPPLPCTTTS
                     QEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQRSMRCYRKA
                     CRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSLSPPNKRWRR
                     SSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYSSYRSNDHYQR
                     QRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVT
                     YRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSK
                     FDSLDFDTLLKQAQKNLRR"
     misc_feature    <1117..2514
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1117..2514
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1873..3330
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1873..3330
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2914..4065
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2914..4065
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4525..4797
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4525..4797
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            139..312
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..459
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..561
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..3418
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3472
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3530
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3598
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..4316
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4454
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4521
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4643
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4795
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..5045
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaaggga tgtccacgtg gctcctgtcc caggctgtcg ggcatctagt atccgcgctg
       61 gagccgcact gccgggaact gggtgtgtcc cagccgctcc cgccatctct tgcctgtgct
      121 gggacctctg gtctggaggt ccatgaggaa ggagatgact ctagctttgt cagtctttct
      181 cgactgggcc catctctaag ggagaaagac ctggaaatgg aggaactgat actgcaggat
      241 gagacactac tagagaccat gcagaactac atggacgcct cccttatatc cctcattgag
      301 gattttggag agagcaggct atctttggag gaccagaatg agatgtcgct gctcacagct
      361 ctgacggaga tcttggacaa tgcagattct gagaacctgt ccccgtttga taccattcct
      421 gattcagagc tgctcgtgtc tcctcgggag agctcctctc tgcacaagct gctcaatctc
      481 tctcggacac ctccagaacg tgaccgcatc cccgcaatgg accctttggg gcccagcgca
      541 ggaagtagtc gggtgagtgg ggttgagatg tcccttgcag attctccgtg ggacttctct
      601 ccacctcctt tcttggaaac ttcttcccct aagctgccta gctggagatc ctcaagacca
      661 agacctcgat ggagtcagtc tcctcctccc cagcagcgca gtgatggaga ggaggaggaa
      721 gaggttgccg gcttcagtgg tcagatgctt gatggcgaac ttgacaactc ggtgaatacc
      781 ttggatttcc ccatgcacct ggcatgccct gaggaagaag acaagtcagg ggcagcaaat
      841 gtggcagtgt cagcacctgg tgacgagagc atctcctcct tgagtgagct ggtacgggcc
      901 atgcacccct actgcttacc caacctcacc cagttggcat cacttgacgc tgagcttcag
      961 gagcaggctg atgatctgac actgcctgag ggttgtgtgg tgctggagat tgtgggccag
     1021 gcagccacag ctggtgatga cctggagatc ccagtggtcg tgcggcagat tccttcagga
     1081 tcccagtctg tgctcctaga tgggtctgta gggactgatc ctgccttgca gctactcatg
     1141 cccgccatgg agcctggaac agaagatggt gtgcctaaag tcgctccttg ccctgatcaa
     1201 gaattaccac tgagctctgc ctgcttattg gagcccaggg acatcatgga gtcattggcc
     1261 cccaaggagc ctcggaacct acctgccaat gcaagtgagg gttctcagag agttcccaga
     1321 aagggtagga agaagaagaa gaaggagcag ccaacagcct gtttggaagg ctgtaccagg
     1381 aggctgaggt catcttctcg tggacagtct actgtggcta cagaggtgaa ctctcaggca
     1441 ggcaacttac agaaacagcc tcaggaagag cttcagagag agactgcggc ccctcagagc
     1501 agagggaagc cacgggcttg ggctcgggcc tgggcagctg ccttggagaa aactgggtct
     1561 gaagacccag aggaccagaa tgcaggacag gatagtcctg ctgaggaaga tgttctagaa
     1621 ctccgtccta agctggtgga gactagccaa gccgacccca cgctctcact aaacgactct
     1681 gctcgagctg actccatccc agttaactct gttgaaggtg actccactgc agtggacact
     1741 gctgtacctg ttgaccaggc ttcatcttgt acagagctgg ttggttctct ctcaggaggc
     1801 ccaattctga gtagcccagt cctagatgac aggacaggag ttgaacctgc agtggctatt
     1861 cccacttcaa atcacttgtc tccagctgat gctatcctag ctaacccagg gacagctgac
     1921 cctgctccaa atggcctggc tccaggagat cctgtgctag ttaagtgcag accaactgat
     1981 cctagacgtg cagctgctgc tgccactgct gctcaggggc ctcgtccttc cctagagccc
     2041 tcagaccatc ctaaggtcat cacccctgaa gtcaaggatg ctggaggtcc tctgaaggtg
     2101 gaaggtagta ccagtgctac aacccaggaa gccagacctc ggcccctcag cctatctgag
     2161 taccgtcaac gacggcggca acggcaaata gaagcagaag acaggaattc tcagccccca
     2221 gctggaaagt ggccaagtct cccagagacg cccaaagggc tggcagatat cccttgtctt
     2281 gttccatcag ccccaaccaa gaagacagcc ccacagagaa gccctatagc tgtaccagag
     2341 acttgttctg tatctgtggg ttctaaccct gtttccccta ctcctgagcc atctgcaagc
     2401 aaacttatgg tttcaactca ctctgaacag gtgtcatctc atgagatgcc acttccagtt
     2461 agacttcccc ctcctacatt gcagtctatg gctcctgctg ggcccacccc ttctacagtg
     2521 cccacgccat tgcctttccc tccgagctta cctcctctgc ttcctcttcc tgcaagtggt
     2581 cctggtgtcc ccagcctgcc cccacctcct ttgcaacctc ctggacttcc agtatcaatg
     2641 agacaaatgc cacctgaccc ctatactcag tatgcccctg tgccgccctg gccttgttac
     2701 ccctctgtat ctccttctgg ctattcttgt ctgcccccac caccagcgat gcccatagtg
     2761 tcgggtaccc ctggtaccta tgctgtaccc ccaacttgca atgtgccttg ggtaccccct
     2821 cctgcaccag tctcacctta tagctccagc tctgcctatg ggtcccttgg gtggggccca
     2881 gggttgcaac agcctccctt ttggtctact gtttctccac ctccattgtc ttcagcctct
     2941 actggtagag ctgttccccc acccagtgtg gaacccagta acagttcagc tggtcctccg
     3001 gaagatacac ttcctgtgcc agtgacccct tccctgagct ctcggccagc cagccccata
     3061 gctccaccag cagaacctac gaagctggag gctcagccag tgcctgtctc tccccaaccg
     3121 aaacacaaag tgtcccctgt ggtacagagt ccccagatca aggttctacc aactctgtct
     3181 gctgagggcg tggctattgg ggaatctgaa tcagagaggc taaagccgga gacccaggag
     3241 aacagaccaa gggagaagcc tatctctacg gctacgaagg ctgttctgtt accaaagcag
     3301 agcactgtcg caaaactgcc tgccgtccat ccagcccggc taaggaggct gtccttcctg
     3361 cccaccccac gtgctcaggg ttctgaggat gtggtgcagg cattcatcag tgagattggg
     3421 attgaagcat cagacctgtc cagtctgttg gagcagtttg agaaatcaga agccaaaaag
     3481 gagtgtcctc tcccggctcc tgctgacagc gtggctgtag gaaactcagg cattgacact
     3541 ccccaggaga agaaacccct agaccggtta cacgccccag aactggccaa cgtggcaggg
     3601 ctcaccccgc cagctacccc tccccaccag ttatggaaac ccctggctgc tgtctcactg
     3661 ttggccaaag ccaaatctcc taaatctact gcccaagagg gaaccctgaa gcctgaagga
     3721 attacagagg ccaaacctcc agctgcagcc tgcctccaag aaggggtccg tggccctagt
     3781 ccagtccatg tgggctctgg ggaccatgac tattgtgtcc gaagcaggac acccccaaaa
     3841 aagatgcctg ccctagtcat ttcagagatg ggctctcgat ggaatgtcaa gcgccatcag
     3901 gacatcacta tcaaacctgt cttgtcattg ggctcagctg cccccccact cccatgcaca
     3961 accacttccc aggaaccgct tgatcacagg actagcagtg agcaggcaga tccgtcagcg
     4021 ccttgttttg ccccatccac cttgctgtct cctgaggcct caccctgccg gaatgaaatg
     4081 aacactagga ctccctctga gcccccagac aagcagcggt caatgcgctg ttaccgaaaa
     4141 gcctgcagat cagccagccc cccaagtcgg ggctggcaag gccgccgtgg ccgtagcagc
     4201 cgttctgtca gctctgggtc cagccggacc agtgaagcat cctcatcctc atcggtgtct
     4261 tcctcatccc ggtcccggtc caggtccctc tcccccccaa acaagaggtg gcgaaggtcc
     4321 agctgcagtt cctctggacg gtccagaaga tgttcctcct cttcctcttc ttcctcctcc
     4381 tcatcttcat catccagttc cagaagccgg tctccctctg tgtccccttg caggagaagt
     4441 gaccggaggc ggcggtacag ctcttaccgt tcaaatgacc attaccaaag gcagagagta
     4501 ctgcagaagg agcgtgcaat agaagagaga agggtggtct tcattgggaa aatacctggc
     4561 cgcatgactc ggtcggagct gaagcagagg ttctctgttt ttggagagat tgaggagtgt
     4621 accattcatt ttcgtgtcca aggtgacaac tatggtttcg tcacttaccg gtatgctgaa
     4681 gaggcatttg cagccattga gagtggccac aagttgcggc aggcagacga gcagcccttt
     4741 gatctctgct ttgggggccg aaggcagttc tgcaagagga gttactctga tcttgactcc
     4801 aatcgggaag actttgatcc tgctcctgtc aagagcaaat tcgattctct tgactttgat
     4861 actttgttga aacaggccca gaagaaccta aggaggtaac cctgggcttt cctcccccat
     4921 ccattttctc tggaggtgtc caacctctca accccctccc ctactctagg ggagagagct
     4981 gctagtgtgg aaagactttt ataaggaaat gaaaaaaagt taaataaaaa tatgttaaat
     5041 cggga
//
LOCUS       NM_001437567            1519 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), transcript
            variant 2, mRNA.
ACCESSION   NM_001437567 XM_039109088
VERSION     NM_001437567.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1519)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_039109088.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2516049.1,
                                           SRR26643294.7067.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000001.1  256370526-256370776 c
            252-427             JAXUCZ010000001.1  256369932-256370107 c
            428-523             JAXUCZ010000001.1  256363461-256363556 c
            524-592             JAXUCZ010000001.1  256358861-256358929 c
            593-760             JAXUCZ010000001.1  256351463-256351630 c
            761-884             JAXUCZ010000001.1  256350493-256350616 c
            885-1056            JAXUCZ010000001.1  256348306-256348477 c
            1057-1176           JAXUCZ010000001.1  256344882-256345001 c
            1177-1249           JAXUCZ010000001.1  256342471-256342543 c
            1250-1519           JAXUCZ010000001.1  256336916-256337185 c
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1519
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..251
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..427
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    268..270
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="upstream in-frame stop codon"
     CDS             274..1407
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 1; CST complex subunit STN1; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide-binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1 isoform 1"
                     /protein_id="NP_001424496.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNSKDTLDLAGLTALL
                     SEKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVF
                     KNALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNHVEKGCHLM
                     HVLNCVLLNLRWDLNKAVLQQVLELLEDQSDIVSTGDHYYTAF"
     misc_feature    466..768
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    466..768
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    order(466..468,694..696,700..702,706..708,760..762)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(466..468,694..696,700..702,706..708,760..762)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(481..489,514..525,529..531,547..555,559..561,
                     691..693,712..720,739..747)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(481..489,514..525,529..531,547..555,559..561,
                     691..693,712..720,739..747)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    907..1404
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    907..1404
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     exon            428..523
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..592
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..760
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..884
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1056
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1176
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1249
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1519
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcgcaa ccggaactat ttcggcaatc ttggccaact gctcctgctc cgggagaggc
       61 tgtaaaccgc tctgattctg cctccttttc ctttcctccg ctcttcccag aaggtgaaat
      121 gtcgaagagt ggatagacac acctccaggg cccaaagtcc acggccacag gggcgccatt
      181 cactctccgg actcattcgt taaaactcct ttggggtacg cctgtgtgga tggttatcct
      241 caaagtgaag aagtcttggc tcagggttag cagatgccag aaccttgcct tttgatgcag
      301 tgcgaatcca gtccaaaaga agaggagatc ccgtccctct tttggggtct ggatcccgtg
      361 tttctagcct ttgcaaaact ctacatcaag gacatcctgg agatgaagga gtcccaacaa
      421 gtgccaggca tgtattttta caatggacat ccaataagac gggtggatat catgggagct
      481 gtcatcagtg tgaaagagag agagactttc tacagctatg gagtggatga cgccacaggg
      541 gttataaact gtgtgtgctg gaaaaggcca agcaatgccg agtcttcatc agacccagct
      601 attctgagca cttcgagaga actcagcatg acctcacagc ttaagaaact gcaggagacc
      661 attgagcaga aaaccaagat cgggattggg gatatcatcc gagtccgagg ctacgtgcgt
      721 atgttccgag aagagcgaga gatctgtgcc accatttatt ataaggtgga cgatccagtg
      781 tggaacatgc aaattgcaag gatgcttgag ctgccagagc tctacaagaa ggtgtatgac
      841 cagcccttcc ggaacccagc cctaaaggag gaagaggcac taaacagtaa agacactttg
      901 gatctcgctg gcctcacggc tttgttgagt gagaaagtta aagaatttct ccaggagaag
      961 aaagtgcaaa gcttctacca gaaggagctg gaaatggtgg agcccttgca gtctctggcc
     1021 agtcagcccg tgacccacag cacgtgctcg gaccaagtgg agttaaagaa cgacgccgct
     1081 tctgacatac acagtgtgtt taagaatgct ctgcacctgc ttcaggaaaa ggggttcgtg
     1141 ttccagagag acggtggctc cgataagctg tactatgtta ccagtaagga caaagacctg
     1201 caccagaaga tctaccagat cattaaggaa gactgtcaga aaccaaatca tgtggagaag
     1261 ggctgccact tgatgcacgt cctgaactgc gtgctcctca acctccgctg ggacctgaac
     1321 aaggctgtgc tgcagcaggt gctggagctc ctggaggacc agagcgacat tgtgagtact
     1381 ggagaccact actacacggc cttctgagca gagccacgga gaggcagcag gcagctttac
     1441 cccaggttct gctcccaggc gttgtagaga cttatttgtg tataatcccc taataaagtc
     1501 tgatacagcc acaggaaaa
//
LOCUS       NR_199361               3025 bp    RNA     linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus R3H domain and coiled-coil containing 1-like
            (R3hcc1l), transcript variant 3, non-coding RNA.
ACCESSION   NR_199361 XR_010066339
VERSION     NR_199361.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Kashima,I., Jonas,S., Jayachandran,U., Buchwald,G., Conti,E.,
            Lupas,A.N. and Izaurralde,E.
  TITLE     SMG6 interacts with the exon junction complex via two conserved
            EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 24 (21), 2440-2450 (2010)
   PUBMED   20930030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XR_010066339.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5684.1,
                                           SRR26643289.4525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  251266525-251266569
            46-1835             JAXUCZ010000001.1  251313689-251315478
            1836-2011           JAXUCZ010000001.1  251327567-251327742
            2012-2107           JAXUCZ010000001.1  251334816-251334911
            2108-2248           JAXUCZ010000001.1  251335368-251335508
            2249-3025           JAXUCZ010000001.1  251343719-251344495
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3025
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /note="R3H domain and coiled-coil containing 1-like"
                     /db_xref="GeneID:293953"
                     /db_xref="RGD:1307934"
     misc_RNA        1..3025
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /product="R3H domain and coiled-coil containing 1-like,
                     transcript variant 3"
                     /db_xref="GeneID:293953"
                     /db_xref="RGD:1307934"
     exon            1..45
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
     exon            46..1835
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    60..2033
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001427847.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            1836..2011
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2107
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2248
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..3025
                     /gene="R3hcc1l"
                     /gene_synonym="RGD1307934"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgcttca ccgaggcggc ggaagcggag agctacagcg tcccgatcaa agtggtgcca
       61 tgcagcaaga agcagagaga tgcagagttc gaaccaaaag gcctgacatg gcactttatg
      121 tacctaaagc tcgaagggga gcagctctcc tcaagtcagg tgaccaggaa gaaaaccagg
      181 ggcctcctgc ctttgtgctg agagaacaaa aagaagattg tcttcctcag aagacttcta
      241 caagcaaacc cgagtcccac agactaagtg caggtcaatc tggtagaaag gatagtaact
      301 gtagggaagg aaagagatct ccaccaaaac taaggaaaga caggtcccca ccaaaaagga
      361 ataaagagaa ggcttgttct aagagaggaa ctggaaaacc catagatgcc tcatcccaag
      421 aacatcagaa cagtgctcac gatgctgcgg ctgtatctag cataccttta cgaagacttt
      481 ttaaaccaaa ggagatggag tgtgtggaag ttcagacttc aggagggaca ggaccctggg
      541 gggtgcctcc atcacagtct tcctcagaag tcagtgctgc acaggttcca aacagaccgt
      601 tccagaacgt ggaactctgt gatttcagtg gggaaacttt tgtaaataga aatttggaaa
      661 gcagcattgt aactgaggcc aaagttatgg aactagtctc tcagtttcct caagttgtta
      721 caactatgct gaaaccagat ggtatggcta tgccagggac actaagttct gattctgaaa
      781 ctgcaccgta tggtgtggaa acatcacatg ggatgtcaaa gcacagtcct gggaacatct
      841 ctgcaatttc tgttcctgga gagccagatg atgctgcgca tccaactttt gtagacttcg
      901 aagctgaaag tgagagtaca gtcaacagta cagagtctgt cttgggtcaa aatggtgtag
      961 attccatttc tgagactatg ggtaacgttt ctcttaaaat ggctatagtc agcaagctag
     1021 agagcacaaa tggtattatt gacccagcag tgactggaga gtgtgggaat gacagctctg
     1081 ctgatgagtt gtgtgtgaag tctgaacctt ccgatacagt ggaccttgtt catgaaatag
     1141 acacaggtaa tggatttagg gatgtatgcg acagtgccag caaggcaggt atggtggaca
     1201 ttgcaggtac agtttgtgac cctgtgactg taggcagccc ttgtacagct gcagttagag
     1261 aatctggtga gagtagtggc aacatgagaa attcctcaga ttatatagaa atgagtgcag
     1321 atgtagcccg acttgattca gctaagagtg agacgaactc tgaaaacagt agcagcctaa
     1381 atgcttgctc agatatttat gctgggagta ttgcatctgg ttttacagcg tcaacaggaa
     1441 agttgacaga aagtgtgcca gattgtgctt cctctttacc cataaagaag actgctgata
     1501 gtgacattac cccttgtctg gactctgaac tgagcatgtc gaatggatca ggcatacttg
     1561 tggagagtgc cttggccagt gatctggata ctactgagga gatgacagag gccttgcatg
     1621 acctaagaac tgctgaagaa tttaaaacaa aagaggaaga tgactcagag agtagagtgt
     1681 gtggcatacc attttctgat tcatctgtgg acacatctgt aggtctaaaa acaacagata
     1741 cttctcatac acaaggaagt attgctgtgg aggaaagctg ggagtctatg tttaatgatg
     1801 atggtgattg tgtagaccct cgtcttctac aagagttatc aggaaatatg aagaacagaa
     1861 aaagtatcca ggagcctaga tttgattatt acaaccatga acttcctgat attgacctca
     1921 gtgaatgtga attcccacat gtcattgaaa tttatgactt tcctcaagaa tttcgtacag
     1981 aagacctttt gcggattttc tgcagttacc actcgagatg ccctgggtat taagcatacc
     2041 atggtgaaga tccggccctt gtcacaggcc acaagagcag ccaaggccaa ggctagggct
     2101 tgtgctgagt ttctccagcc agcaaaggag cgacctgaga cttcagcggc cttagccaga
     2161 cggctggtca tcagtgccct tggggttcga agcagacaga gcaaaactga acgggaagcc
     2221 gaactcagga agctgcagga agcccgagaa agaaaacgac tggaagccaa gcaacgggaa
     2281 gatatctggg aaggcagaga ccaatctgtg gtttgaacat cacttactca aaggaatgaa
     2341 tccatggatt aggatgtgtt tgatattctt gagacaagag gatctttcca gagctgtgca
     2401 catgcagatg agcatgttaa agaaaacggg aacaagacag aagactggag ggcttagaga
     2461 gaacgagcag tccagtcctc actcctgaat tcagacctgt ccactggagt agagatgtta
     2521 acaggcactg tcggaggaag gaaaatggaa gaagtggctt tctaagagtc ctgtgtggag
     2581 caggccatgt tagtgtgggt cccgcctcca ggaagtctga agcaaatgta aagcaaaaca
     2641 gaggattcga gcctgcagtg acaggagttg gaggtccatg gcagggtgtt cctcagtact
     2701 tcagagttga gcactgcaga attaggacag taaggggaag tggaagcaac tcccagacac
     2761 gagtgcctgg tgcaccgggc acgggcagag actacactgc tggctgcaga actccaaagc
     2821 cactgaccct tcggcacatc gtgggcattc ggactcctga gtttgtacta agcttggtgt
     2881 ctggcactgt tccagctaca cggcagccag gggtctgcca cctaccttcc tcatgaagac
     2941 cagtcctagg agctgagtgc cagctccagt ttaatcagtg atatgttgtg agagggagaa
     3001 attaaaggct attttataac ataaa
//
LOCUS       NR_199362               6466 bp    RNA     linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 6, non-coding RNA.
ACCESSION   NR_199362 XR_005487826
VERSION     NR_199362.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6466)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6466)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 6466)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 6466)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 6466)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XR_005487826.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.946.1,
                                           SRR26643299.1177.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000001.1  78401913-78402166   c
            255-412             JAXUCZ010000001.1  78401477-78401634   c
            413-453             JAXUCZ010000001.1  78398316-78398356   c
            454-512             JAXUCZ010000001.1  78398010-78398068   c
            513-674             JAXUCZ010000001.1  78397058-78397219   c
            675-824             JAXUCZ010000001.1  78396669-78396818   c
            825-907             JAXUCZ010000001.1  78396228-78396310   c
            908-1172            JAXUCZ010000001.1  78395632-78395896   c
            1173-1299           JAXUCZ010000001.1  78395199-78395325   c
            1300-1388           JAXUCZ010000001.1  78394918-78395006   c
            1389-1463           JAXUCZ010000001.1  78394740-78394814   c
            1464-1612           JAXUCZ010000001.1  78394489-78394637   c
            1613-1754           JAXUCZ010000001.1  78392927-78393068   c
            1755-1783           JAXUCZ010000001.1  78392786-78392814   c
            1784-2583           JAXUCZ010000001.1  78391859-78392658   c
            2584-2713           JAXUCZ010000001.1  78389932-78390061   c
            2714-2845           JAXUCZ010000001.1  78389705-78389836   c
            2846-2954           JAXUCZ010000001.1  78389331-78389439   c
            2955-3129           JAXUCZ010000001.1  78389017-78389191   c
            3130-3262           JAXUCZ010000001.1  78388632-78388764   c
            3263-6466           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..6466
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..6466
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     misc_RNA        1..6466
                     /gene="Eps8l1"
                     /product="EPS8 signaling adaptor L1, transcript variant 6"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..254
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..412
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    396..1799
                     /gene="Eps8l1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001108467.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            413..453
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..512
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..674
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..824
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..907
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1172
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1299
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1388
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1463
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1612
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1754
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1783
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2583
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2713
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2845
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2954
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3129
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3262
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..6466
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagcc agcaggcagg tgagaaggcc aggcctagtg tgagtgagga gagctgagtt
       61 gtagggtctt ggatctgaga cacaaggtat cctctggacc ccggatctga acaaggagag
      121 ctgatctaga ttcttggatc tgagagataa ggttctcccc tggacccctg ggtttgaaca
      181 aggagggtct ggagtctaga ctattggatc tgagagagga ggtccctcct ggacccctgg
      241 gtcttagcaa ggaggagcca ggctggtgcc tgaacatctc agtttgaggg aggaggcttg
      301 gatcaggatc ctgtgcctga agccaagtca gtcactcacg tctttgctgg ctctcaagga
      361 acctccaagc ggacagagca cctcttctgg ccaccatgag caccaccaca gggcctgaag
      421 ctgcacccaa accaagtgca aagtctatct atgagcagag aaaacgttac tccactgtgg
      481 ttatggctga tgtgtcccag tatcatgtca atcacctggt caccttctgc ttgggggagg
      541 aagatggcgt gcacactgtg gaagatgctt ccagaaagct ggcagtcatg gacagccagg
      601 ggcgtgtctg ggcacaggag atgctactga gagtgtcacc tggtcatgtc actctgcttg
      661 atccagtctc taaggaggaa ctagagtcat atcctctcga cgccatcgta cgctgcgacg
      721 cggtgatgcc ccgaggacgg agccgctcgt tgctgctcct ggtgtgccaa gagccagagc
      781 gtgcacagcc agatgtccat ttcttccagg gcctgctcct cggggcggag ctgatccgtg
      841 aggacatcca aggggctctg cagaactacc gctccggacg tggggaacgc agggcggcag
      901 cactcagggc tacgcaggag gagctgcgac gcggtgcctc tccagcagcg gagaccccgc
      961 ccttacagcg tcgcccttct gtccgcgcgg tgatcaacac ggtggaacca tccgcggtgc
     1021 gcgggcgacc ccaagtggag ccaattccag agactgagga agcgaggaaa cccgacccag
     1081 cgcgcacgac gactaggagc tctgatccta cctccccaga cctgggccca aggggtcctg
     1141 agctggccgg tctgcaggcg gagcgggatg tggatatcct gaaccatgtg tttgacgacg
     1201 tggagagttt tgtatccaga ctgcaaaagt cagcagaggc tacccgggtt ttggagcacc
     1261 gtgagcgcgg ccgcaggaca cgacgccgag ctgctggaga gggcctgctg accctaaggg
     1321 ccaagccacc cacagaggct gaatacactg atgtgcttca gaaaatcaaa tacgccttca
     1381 gtctgctggc ccggttgcgg ggcaacatcg ccaacccctc ctctccagag ctgttacact
     1441 ttctgttcgg acctctgcag atgattgtga acacttcagg cggccctgag ttcccgagga
     1501 gtgtgcgacg accacatttg accttggagg ctgtggcgct gctccgcgac aatgtcactc
     1561 ctcgtgaaaa tgaactatgg acctcactgg gggactcctg gacccgccca ggggtggagc
     1621 tgccccctga agaagggtct ccatacagtc cggaattcta cagcggttgg gaacctccgg
     1681 ccactgaccc gcagggccgc ccctgggagg acccagtgga aaaacagcta cagcacgaga
     1741 agcggcgcag gcagcaaagc gccccccaag tcgcggtcaa tgggtgggtg aggtggtgag
     1801 gaagcggggc tggggctagg gtgggggtag gaaaaagcag ggagggggga ggagcccaga
     1861 ttcatgggtc caagggaaga gggagggaat ggaggcttaa attcgtgaag ctatgagtga
     1921 taggcactaa gagttggtat gtctaagggc ttggatccca gtgtcctcaa aaaactgaaa
     1981 aagtgcagtt tggtgttcta gaaccaggga aagcattatg tttggatccg gagagcacag
     2041 aatactggat gttagggcga agatgaggac ttaaaagcag ggttggtact tggagaagct
     2101 ggggacaaat gtgagaaaac attagaaagt gttggcatcc ctaggctact aactggggtg
     2161 agacttctgg cttcctaatg ctctaagaaa tagcacctac tgggggcaga ctggactgct
     2221 gacagagcta aaaagatcta gggacttgaa ggtcaaaacc tggactcctg cctactttgc
     2281 tgggaaagaa agagctagga acctaaatgt atggttctaa cacatcgtgg aagctgaggg
     2341 tttgtagact caggagagga agatgatgga gagggtcaca actctaggat ccttgggcaa
     2401 atagaggcca aaagtggagg gagtgggtgt gcattgagaa caaaatgcta gagctggaga
     2461 agatgaatgg gggtctaagt gagggcccca gcagagggtc tcagcaggga ctgcatactg
     2521 ggagctgtca gccccacaca cggggtgcca agaccctgaa gagcccccct ctcccttcca
     2581 cagtcatcaa gatccagaac tggaaactga gtcccagcta gaagagaaag ccagaaaatg
     2641 ggttctgtgt aattatgact tccaggcccg aaatggcagc gagctatctg tcaagcaccg
     2701 agatgtgttg gaggtcctgg atgacaggcg caaatggtgg aaggttcggg accatcaagg
     2761 acaagagggc tatgtaccct ataatatcct gacaccccac cctggacctc aggtgcactg
     2821 cagccaaagc tccgcaataa acctagagac tagcccacct cctcccccac ctgctgcagc
     2881 tccagccccc actcaggtgc ggccccagtg ggacagttgc gacagtctaa acagtttgga
     2941 tcccagcgac aaggagaaat tttcccagat gctttgtgtc aatgaggagc tgcaggcgcg
     3001 cctggcgcag ggccgttcgg gtcccagccg ggtaaccccg gggcttcgag ccccggagcc
     3061 ccagctcagc ccacgctctg aggcctcggt ggtccgtgcc tggctgcaga ccaagggctt
     3121 tagctccggg actgtggatg cgcttggagt gctgactggc gcacagctgt tctcgcttca
     3181 aaaggaagag ttgcggtcgg tgtgcccgga agaaggggcg cgagtatata gccaagtcac
     3241 tgtgcagcgg gcgctactgg aggacagaga aaaagtatca gagctggagg ccgtaatgga
     3301 gaaacaaaag aaaaaagtgg aaggcgagac caaaacagaa gtcatttgat cctggttcat
     3361 tcataaaaag tgatgagatg gtggggttcc cagcgccccg aaagacaaca gtcaccagac
     3421 tcctccccca acgtcagtag cagtagatgc cgtaaaggac cgcccaccct gggttccccg
     3481 cggtcctggc gggcggactg cattgacagt gctgaccgga acctttccag agggactgat
     3541 gggaatgggg aagggaacag agcatggaca ctactagaaa ggcacgccca agaggcgcga
     3601 tgatggccct gtgcgttgtg atgcgctata aacagcctcc ttttaggcta tgtccacctg
     3661 ctgtcccccc ccacacacac cccctctctt gccggccacc aagatgccag gaatctagaa
     3721 gacatccata ttttctctcc acaaacctgg agattccaac ccaggcttcc tcttaagcac
     3781 caatctatcc ttgctctaac actatctaca atctctctct ggttcaaaat cctttcctgt
     3841 caactagcgt gaggcctggg attttccttt caaaggcaga gggtgtctcc ttccaccccc
     3901 cattttgggt caacccctcc aatcacaggc atttccgcac ttactgcttc tgctggttgg
     3961 agcagcttcc atcaatgtgg ctcaactcac ctacattcca tggatgcctg tgccagccac
     4021 taaggattca gctatgaaga tcgggatgct ataggctctt gggtcttcca gtccccagaa
     4081 ctttctccct gccaagtcct gcaacttgtc tggtttattt aggtggctag taagagctgg
     4141 ttttctcatt gagactagat acccctaagg tttttttttt tcctgctgtg gcacttccct
     4201 ttgcatccct aaaacacttc aagagtcaca ccagtgcagt tggcctctgc tctccaggca
     4261 gttcagctct tacctgagcc accagtggca cacctcaaat ccaagctaga aaagccagcc
     4321 tttgggctga cagcttcact atacccactt tgctccagaa cactatccac aatagatctc
     4381 tttcccactt cctgtctacc tctcaagcat gtctcttggc ttctcccgac agatgggata
     4441 aaacctaacc ccagcatgaa agttgatata catgaccact ccaggttcag ggccctcttc
     4501 ctcccttttc aggaccccaa gcattggttc gtgctgttgg ctctgctagg aatgtcctgg
     4561 ccttttggag tctaatcact gcctgtcgtt ccttatgtca gggttgggtg gttagttggt
     4621 tgattggttt tgttggagat agtctggata tagcctcaaa gtctcaattc tgtttcagtt
     4681 tcctgcatgc tgagattcct ggcagatgcc ctcctgcctt cttttctaag aaacttaaaa
     4741 acacaagcag tttgcccaaa ctgtttttga ctctgcagtg agctcccagg ctccaggctg
     4801 caggctgccg tgcaggcagg gaccagctgg cttgctggaa caccagatgc ctctagctct
     4861 ctatggtctg gaatctgatc atttctatct gcttatcctg acttcatcct ttgttgatca
     4921 ccctgtccgt cactcctcca atctgtatcg atgttcagac atagggacct gttacaactc
     4981 aagtcagatg gcagtctgct ggccagacct cccacctcag agctcaagtc cttagtagag
     5041 ccacatccct gcacaaagcc agcagcactt caacacttcc tctgctattc agccccaagt
     5101 ttcttcctgc accttagcat gccaggccta ctctacccta tgacctttgc atctcatcac
     5161 tgaaaatggg cttccttcag acatatggct cactctgcta ccttctagtt ccacgtgtca
     5221 tgtcttgggt ctactttgac taccataaac accatacata cacaccagat acatacccaa
     5281 catacaccat aaacatcagc catgccacgc accacacaaa atgcacacca cacacacacc
     5341 gtccacccct gacaacaccc atccacccac atccacttcc cttctctttc tccacagcac
     5401 tacagctgaa atccatacac tagttacctc tctcctgcag aacctggctc ctggcctaag
     5461 ctactcactc ttgggactcc agtaggtagg acagagccca gctggtagtg taggcagttg
     5521 ctcctgacta taagaatgaa ggtacaatga atcacaagac tgcctcctac tattccagcc
     5581 aatgtggccg tggaggactg agggaactca ccatcactta ttcatttccc agagaagtta
     5641 cacttgtgga gttttctgtg atccatccca cattttcaat gtcagccatt aactccactc
     5701 ctttcagggg aactgagggc aaatctgggc actccagccc cttatcacag caccatgggc
     5761 ttccttctga cccttcccac ctcatctggg atcctttgct ccagctgctc acttagcaag
     5821 gtgccctccc tactcctgtg agcacgctcc aaccttgcct ccaactgtac ctaccccatc
     5881 caaatgggct tggtcagcct gagtcaacaa gcagaacaag tcactgagtg gcaatgtcac
     5941 gactttattt atggtgcctg tgctttgtct caaaaatacc ttctcctcct ccccagacaa
     6001 taggtgggga ggaggcagca aaaatagaac atccctccct attgcacatg gaccctatat
     6061 acaggcccac ctggcagagg ccagtgggac tcttggcaca ttcctggtcc ctgctgggga
     6121 gggggggagg agtgctgggt agcatcacac gtgaggtggg accctggggc aaccactctg
     6181 cttctggata cttatctttg catttcttgg tccttgtttc cttcttggtc ccatctctga
     6241 tgctcagagc aacatctcag caacatctcc ctacctggct cagcctccca cctctatcct
     6301 gacctcagag aaccccttgg ttcctgggga ctctgtgctt tcctcccggt tctgaggtcc
     6361 cgagaggtta tggcttctca gcaacttccc ccagagcctt gtcactcatg ttcacgcggg
     6421 ggaaagggtg cgtgtgtcag aagcagcagt ataaatatgg tgcggg
//
LOCUS       NM_001106374            2070 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus lipase, family member K (Lipk), transcript
            variant 2, mRNA.
ACCESSION   NM_001106374 XM_001079875 XM_220067
VERSION     NM_001106374.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220067.4, XM_001079875.1.
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2070
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="lipase, family member K"
                     /db_xref="GeneID:294094"
                     /db_xref="RGD:1309724"
     exon            1..95
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="upstream in-frame stop codon"
     exon            96..205
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1300
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="lipase-like, ab-hydrolase domain containing 2;
                     lipase K; lipase member K"
                     /codon_start=1
                     /product="lipase member K precursor"
                     /protein_id="NP_001099844.1"
                     /db_xref="GeneID:294094"
                     /db_xref="RGD:1309724"
                     /translation="MWWLLATCCMFLPGPIYGHMQESITNPEANMNISEIISYWGYPY
                     ERHDVVTEDGYILGTYRIPHGKGCSRKAVPKAVVYLQHGLIASASNWICNLPNNSLAF
                     LLADSGYDVWLGNSRGNTWSRKHLRLSPKSPEYWAFSLDEMAKYDLPATINLILEKSG
                     QKQLFYVGHSQGTTIAFIAFSTNPELAKKIRMFFALAPVVTVKYTQSPMKKLTTLSRK
                     AVKILFGDKMFSTHTWLEQFIATKVCNRKLFRQLCSNFLFSLSGFDPQNLNMSRLDVY
                     MAQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPDQNMMHFNQLTPPVYNISKMRVPTA
                     MWSGGRDVVADEKDTKNLLPKVANLIYYKEIPHYNHMDFYLGQDAPQEVYRDLITMME
                     ESLQN"
     sig_peptide     107..160
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    206..1270
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="triacylglycerol lipase; Region: PLN02872"
                     /db_xref="CDD:215470"
     misc_feature    206..1270
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="triacylglycerol lipase; Region: PLN02872"
                     /db_xref="CDD:215470"
     exon            206..323
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..522
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..632
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..769
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..916
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..988
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1060
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..2070
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatgtttca ctgataggaa actgcggagg gagctggaat caatctgttg ctctctcaca
       61 acttgaagac tgacactcag aagagctgag atctggcaga ctccaaatgt ggtggctttt
      121 agcaacatgt tgtatgtttc ttcctggacc catatatggc catatgcaag agagcatcac
      181 aaatcctgaa gccaatatga acattagtga aattatttct tactggggct acccttatga
      241 aaggcatgat gttgtaacag aggatggtta tatccttgga acttaccgaa ttcctcatgg
      301 gaaaggatgc tcaaggaaag cagttccgaa ggcagttgtg tatctgcagc atggcttaat
      361 tgcatccgcc agtaactgga tttgcaacct gcccaacaac agcttggctt ttcttctggc
      421 cgatagtggt tatgacgtgt ggttggggaa cagtcgagga aacacctggt ccagaaaaca
      481 cctgcgactg tcacctaagt caccggaata ctgggccttc agtttggatg agatggctaa
      541 atacgatctt ccagctacaa tcaatctgat cttagagaaa agtggacaga agcaactctt
      601 ctatgtgggc cactcgcagg gcaccaccat agcgttcata gcattctcta cgaacccaga
      661 gctggctaaa aagatcagaa tgtttttcgc gctagctcca gtggtcacag taaaatacac
      721 tcaaagccca atgaaaaaat taaccaccct ttccaggaaa gctgtcaaga tattatttgg
      781 tgacaaaatg ttctccacac acacgtggct cgaacaattc attgctacca aagtgtgcaa
      841 ccggaagtta ttccgtcagc tatgcagcaa cttcctgttt tctctaagtg gatttgatcc
      901 ccaaaactta aacatgagtc gcttggatgt ttatatggca cagagtcctg caggaacatc
      961 tgttcagaac atgttgcact gggcccaggc tgtcaattcc ggtcaactcc aagcttttga
     1021 ctggggcaat cctgaccaga acatgatgca cttcaaccag cttaccccac ctgtgtataa
     1081 catcagtaag atgcgagtcc caacagcaat gtggagtggg ggacgcgatg ttgtggcaga
     1141 tgagaaggac actaagaacc tgctccctaa agttgccaac cttatctact acaaggagat
     1201 cccacactac aaccacatgg acttttacct cggacaggac gccccccagg aagtttaccg
     1261 agacctaatt acaatgatgg aagagtcttt gcaaaattaa tggcgctcta tttttataag
     1321 caggtgtgtg tcttgtggta ataataagac agacgctcca atgacacctc agtcattctc
     1381 aacttgtatt gtctcttctt ttctgtgagg aagagaaccg gagcgagggt tctttgtagt
     1441 caacagcatt tgcaaagttg acagaggcca taccccctgg ctaggtgatt ctatttggca
     1501 aaggtgaagg aatgcaatta cttccttcat tagaaaacac agcattacgt ttaagaattc
     1561 taaagcaaga gctacttttt ttacaaacag atgtaatgag gatgttcaca ttgcaaggaa
     1621 cagcgaatgg tttctcagat ctgagaatga tctctggcca ataaccagca aagatcactt
     1681 caaccactct accactgtgc ttgagtgcag acccccatta ttttgtactc aagcttccca
     1741 ctgggaaagc agcctggatt gcaacctgtg aaacccaggg cagagtcctc catgtataac
     1801 atgcctacat tcttgaactc caaaacactg gtatcataaa tatgcttgat ttcaaattgt
     1861 caactttatt ctaatctgtt gtcatcaata ataagatgcc aaaccttaag atatagcaag
     1921 tatataataa atgtaatact tgatcctatt aactatatag tgacattaat accacaattg
     1981 aaagcatata atcttataat tatgtaacac tgtattacat gtaacaatgt atttattgca
     2041 gtatattata tgttgttatt taattggttg
//
LOCUS       NM_001011943            1555 bp    mRNA    linear   ROD 04-APR-2025
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), transcript
            variant 5, mRNA.
ACCESSION   NM_001011943 XM_215273
VERSION     NM_001011943.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079096.1.
            
            On Feb 11, 2005 this sequence version replaced XM_215273.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079096.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1555
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..175
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..351
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="upstream in-frame stop codon"
     CDS             198..1424
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="isoform 3 is encoded by transcript variant 5;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 1; CST complex subunit STN1; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide-binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1 isoform 3"
                     /protein_id="NP_001011943.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNSKDTLDLAGLTALL
                     SEKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVF
                     KNALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNLWCMLPQEA
                     WRGTEEGLAVVVTLSVCLPLPVDVEKGCHLMHVLNCVLLNLRWDLNKAVLQQVLELLE
                     DQSDIVSTGDHYYTAF"
     misc_feature    219..782
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYD2.1);
                     Region: Interaction with CTC1.
                     /evidence=ECO:0000250|UniProtKB:Q9H668"
     misc_feature    390..692
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    390..692
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    order(390..392,618..620,624..626,630..632,684..686)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(390..392,618..620,624..626,630..632,684..686)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(405..413,438..449,453..455,471..479,483..485,
                     615..617,636..644,663..671)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(405..413,438..449,453..455,471..479,483..485,
                     615..617,636..644,663..671)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    798..1109
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYD2.1);
                     Region: Winged helix-turn-helix (wHTH) 1.
                     /evidence=ECO:0000250"
     misc_feature    831..1421
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    831..1421
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    1110..1421
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AYD2.1);
                     Region: Winged helix-turn-helix (wHTH) 1.
                     /evidence=ECO:0000250"
     exon            352..447
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..516
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..684
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..808
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..980
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1100
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1173
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1530
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcctgctc cgggagaggc tgtaaaccgc tctgattctg cctccttttc ctttcctccg
       61 ctcttcccag aaggtgaaat gtcgaagagt ggatagacac acctccaggg cccaaagtcc
      121 acggccacag gggcgccatt cactctccgg actcattcgt taaaactcct ttgggagtct
      181 tggctcaggg ttagcagatg ccagaacctt gccttttgat gcagtgcgaa tccagtccaa
      241 aagaagagga gatcccgtcc ctcttttggg gtctggatcc cgtgtttcta gcctttgcaa
      301 aactctacat caaggacatc ctggagatga aggagtccca acaagtgcca ggcatgtatt
      361 tttacaatgg acatccaata agacgggtgg atatcatggg agctgtcatc agtgtgaaag
      421 agagagagac tttctacagc tatggagtgg atgacgccac aggggttata aactgtgtgt
      481 gctggaaaag gccaagcaat gccgagtctt catcagaccc agctattctg agcacttcga
      541 gagaactcag catgacctca cagcttaaga aactgcagga gaccattgag cagaaaacca
      601 agatcgggat tggggatatc atccgagtcc gaggctacgt gcgtatgttc cgagaagagc
      661 gagagatctg tgccaccatt tattataagg tggacgatcc agtgtggaac atgcaaattg
      721 caaggatgct tgagctgcca gagctctaca agaaggtgta tgaccagccc ttccggaacc
      781 cagccctaaa ggaggaagag gcactaaaca gtaaagacac tttggatctc gctggcctca
      841 cggctttgtt gagtgagaaa gttaaagaat ttctccagga gaagaaagtg caaagcttct
      901 accagaagga gctggaaatg gtggagccct tgcagtctct ggccagtcag cccgtgaccc
      961 acagcacgtg ctcggaccaa gtggagttaa agaacgacgc cgcttctgac atacacagtg
     1021 tgtttaagaa tgctctgcac ctgcttcagg aaaaggggtt cgtgttccag agagacggtg
     1081 gctccgataa gctgtactat gttaccagta aggacaaaga cctgcaccag aagatctacc
     1141 agatcattaa ggaagactgt cagaaaccaa atctgtggtg catgctgcct caggaggcct
     1201 ggagagggac tgaggaaggc ctggccgtcg tggtcacact tagtgtctgc ctgcccttgc
     1261 ccgtagatgt ggagaagggc tgccacttga tgcacgtcct gaactgcgtg ctcctcaacc
     1321 tccgctggga cctgaacaag gctgtgctgc agcaggtgct ggagctcctg gaggaccaga
     1381 gcgacattgt gagtactgga gaccactact acacggcctt ctgagcagag ccacggagag
     1441 gcagcaggca gctttacccc aggttctgct cccaggcgtt gtagagactt atttgtgtat
     1501 aatcctctaa taaagtctga tacagccaca aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_001437473            3612 bp    mRNA    linear   ROD 06-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 3, mRNA.
ACCESSION   NM_001437473 XM_006254721
VERSION     NM_001437473.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3612)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3612)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3612)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3612)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3612)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3612)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3612)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3612)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254721.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2494566.1,
                                           SRR26360194.624517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000018.1  48404539-48404670
            133-235             JAXUCZ010000018.1  48472546-48472648
            236-308             JAXUCZ010000018.1  48485845-48485917
            309-1177            JAXUCZ010000018.1  48504584-48505452
            1178-1357           JAXUCZ010000018.1  48507187-48507366
            1358-1471           JAXUCZ010000018.1  48514668-48514781
            1472-1597           JAXUCZ010000018.1  48523111-48523236
            1598-1767           JAXUCZ010000018.1  48526537-48526706
            1768-1860           JAXUCZ010000018.1  48532075-48532167
            1861-2914           JAXUCZ010000018.1  48532658-48533711
            2915-2985           JAXUCZ010000018.1  48534878-48534948
            2986-3612           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3612
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..132
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..235
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    140..142
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             179..3070
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 1"
                     /protein_id="NP_001424402.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAM
                     YSSCIHLPSNALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     misc_feature    <1139..1702
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1139..1702
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1220..1222,1226..1228,1238..1243,1250..1258,
                     1262..1267,1277..1279,1292..1294,1319..1321,1325..1327,
                     1331..1333,1448..1453,1460..1468,1472..1477,1487..1489,
                     1508..1510,1535..1537,1541..1543,1547..1549,1559..1564,
                     1571..1579,1583..1588,1598..1600,1607..1609,1634..1636)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1220..1222,1226..1228,1238..1243,1250..1258,
                     1262..1267,1277..1279,1292..1294,1319..1321,1325..1327,
                     1331..1333,1448..1453,1460..1468,1472..1477,1487..1489,
                     1508..1510,1535..1537,1541..1543,1547..1549,1559..1564,
                     1571..1579,1583..1588,1598..1600,1607..1609,1634..1636)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1220..1321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1220..1321
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1325..1537
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1325..1537
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1541..1636
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1541..1636
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1709..1840
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1709..1840
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            236..308
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1177
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1357
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1471
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1597
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1767
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1860
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2914
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..2985
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3612
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaacgctc ctcagacaag acagtttccc aggaccgtgt ccaccttcct tttctcattt
       61 cccggtttta tgctggaacc ttggaatggt ttggggacca atgaggtggc agcggttgat
      121 tcatggatcg tggatattat aaatattcga ccttactcaa aatgtacaaa gaagaataat
      181 ggaagcccct gaatatcttg atctggatga aatcgacttt agtgatgaca tttcttattc
      241 agtcacatct ctcaagacca tcccagcact gtgcagaaga tgtgactcac agaacgaaga
      301 cagaccagtt tctagctcta gctggaattg tggtgtctca actctcatta caaacccgca
      361 aaagcccact ggaatcgctg atgtatacag taagttccgc ccggtgaagc gagtttctcc
      421 actgaaacat cagccagaga ctctggagag caatgaaagt gacgaccaga agaacaatac
      481 agtggaatac cagaaagggg gggagactga ccagggcccc cagcctgagg agctcagccc
      541 tgaagatgga gtcggaggct tgccaggcaa gggctcagag cccagccagg cactgggtga
      601 gctggagcac tatgacctcg acatggatga gattctggat gtgccttaca ttaaatccag
      661 tcaacagctg gccccgctca ccaaggtgac ttcagaaaaa aggattttgg gtttatgcac
      721 aactgtcaat ggcctctctg ccaaaacctg ccctattgta agcgctgaga cctccacacc
      781 caacatggct ccattgtgtg ttctttctcc tgtgaaaagc cctcacttac ggaaagtacc
      841 cagtgtcctc cgggaccagc acaagctccc tgcggaagaa tcggagaact cacccgctcc
      901 tggtaaatgc ggccctgcat ttgaatcaga aaaccacagt aaggacttct taaacaaggt
      961 ctttagtgat ccccatagtc ggaaagctga gaagtctggg ccagactgca agctcaggcc
     1021 cttccgcctg cagacctcgg cagcaggagc caaaccagag gagcaggtca acggcgtgag
     1081 ctgggccagt gcccaaggcg cagaagaaag gactgagtac ctgcagaaag taagaagcat
     1141 actgaacatt gtgaacgaag ggcagatatc gctcttgcca cacctagctg cagataatct
     1201 ggacaaaatt cacgacgaga acggaaacaa tctgttacac gttgctgcat caaagggcca
     1261 tgcggaatgt ctgcagcacc tcacgtcgct gatgggcgaa gactgtctga atgaacggaa
     1321 cgcagagcaa ctgactccag cgggcctggc catcaagaat ggtcagctgg agtgtgtacg
     1381 ctggatggtg agtgagacgg aagccattgc ggaactgagt tgttccaagg atttcccaag
     1441 cctaattcat tacgcaggct gctatgggca ggaaaagatt cttctgtggc ttcttcagtt
     1501 catgcaagaa caaggcatct cattggatga agtagatcag gaaggcaaca gtgctgttca
     1561 tgtcgcttca caacatggct accttggatg catacagacc ctggtggagt atggagcaaa
     1621 tgttacgatg cagaaccacg ctggggaaaa gccctcccag agtgccgagc ggcacggcca
     1681 caccctatgt tcccggtacc tcgtggtggt agagacctgt atgtcactgg cctcacaagt
     1741 ggtaaagttg accaagcagc taaaggagca gacagtggag cgcgtcacac tgcagagtca
     1801 actccaacaa cttctggaag cccagaaatc agagggcaag tccctcccat cttcacccag
     1861 ttcaccctcc tcaccagctt ctagaaagtc ccagtggaaa attctagatg cagatgacga
     1921 gtctacaggc aaaagcaaac tgggaaccca ggagggaata caagtccttg gaaacttatc
     1981 cagcagggct aggaccaaag gaaaagacga agactctgat aaaatcctac gtcagttatt
     2041 ggggaaagaa atatcagaga atgtctgcac ccaggaaaag ctgtcattgg aattccagga
     2101 tgctcaggta tcctctagga attcgaaaaa aatacctcta gagaagaggg aactgaagct
     2161 agctagactg cggcagctga tgcagagatc tttgagtgaa tctgacacgg attcaaacaa
     2221 ctctgaggac cccaaaaata ctcctgtgaa aagagtggac agacctagac cacagcccat
     2281 tgtggaaagt gtggagaata tggacagtgc agaaagctta cacctgatga taaagaaaca
     2341 ctctgtggca tcaggacgca ggtttccttt tggtatgaag gcctccaaat ccctggatgg
     2401 gcacagccca tctcccactt cagagagcag tgaaccagat ttggactccc attgcccgag
     2461 cctgggaatg actcctccaa cccaaccttc tacagaagcc actcagtgca gtcctgacag
     2521 tgccactgcc cagaaagttg ctacaagccc caagagtgcc ctcaagtctc catcatccaa
     2581 gcgccggaca tcccaaaact caaaactgag agtgaccttt gaggagcctg ttgtgcaaat
     2641 ggagcaaact agccttgaac taaatggaga aaaagacaaa gagaggggca gggcccccca
     2701 gaggactagt gagtcaggag aacaaatgaa aaggcctttt ggaaccttcc gatccatcat
     2761 ggagagttta agtggtaatc agaacaacaa taataactac cagccagcca gccagctgaa
     2821 gacctgcaca ctacccttga cgtcacttgg aaggaagaca gcagatgcca agggaaaccc
     2881 tgtgagccct gctagcaaag gaaagaataa ggcagcgatg tacagcagct gcattcatct
     2941 tccctctaat gcgctggtcg aagagcatct gcgtgattat gcacggctta atgacatcaa
     3001 aagaaacacg aagaaaactt acaacgtaaa gcacattgct gaaccagagc caaaggaact
     3061 cttcttataa attactctta gtatgagtct cacacatgcc ctctggccac cattgggagt
     3121 taatggactg tggcaatcag accatgagaa caacacctca ccagcgagca gaatatctgg
     3181 atgccttaaa tttataatat gagacttgtt ataagataca ttttggacca tatctgtaca
     3241 tagaacttgt ttgatttctt ttttaatatg ctgtttgaaa acatgatcgg gcaatgtatg
     3301 cattgacaca ttggacattt gattgagtcg accttcttga agcacatcca ccagcacctg
     3361 acacgactag tgtttttgtg aattgcatga ggatttgctg atgttgatta gatgttcacc
     3421 ttctttgtaa caagggcagc tgtggctcag ctcagtgagg ccaggtcact ggttttattt
     3481 tctgtccagt gtgtttttct gtcatttcta cttttttaat aaagaaaatt aaacatttgt
     3541 aacagcagac tctgggcgtg gggggcaggg catctacttt ctaataaatc tgtgaagctc
     3601 tgatttctaa aa
//
LOCUS       NM_001107431            2054 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 6 (Chst6),
            transcript variant 1, mRNA.
ACCESSION   NM_001107431 XM_001077726 XM_226482
VERSION     NM_001107431.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Akama,T.O., Misra,A.K., Hindsgaul,O. and Fukuda,M.N.
  TITLE     Enzymatic synthesis in vitro of the disulfated disaccharide unit of
            corneal keratan sulfate
  JOURNAL   J Biol Chem 277 (45), 42505-42513 (2002)
   PUBMED   12218059
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Akama,T.O., Nakayama,J., Nishida,K., Hiraoka,N., Suzuki,M.,
            McAuliffe,J., Hindsgaul,O., Fukuda,M. and Fukuda,M.N.
  TITLE     Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal
            GlcNac 6-O-sulfotransferase both produce keratan sulfate
  JOURNAL   J Biol Chem 276 (19), 16271-16278 (2001)
   PUBMED   11278593
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Bartes,A., Bhakta,S. and Hemmerich,S.
  TITLE     Sulfation of endothelial mucin by corneal keratan
            N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)
  JOURNAL   Biochem Biophys Res Commun 282 (4), 928-933 (2001)
   PUBMED   11352640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 7, 2025 this sequence version replaced NM_001107431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213398.1, SRR26643299.64821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000019.1  56790125-56790306   c
            183-2054            JAXUCZ010000019.1  56769975-56771846   c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2054
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="carbohydrate sulfotransferase 6"
                     /db_xref="GeneID:307859"
                     /db_xref="RGD:1561144"
     exon            1..182
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    114..116
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="upstream in-frame stop codon"
     CDS             129..1385
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5;
                     carbohydrate sulfotransferase 5"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 5 isoform 1"
                     /protein_id="NP_001100901.1"
                     /db_xref="GeneID:307859"
                     /db_xref="RGD:1561144"
                     /translation="MRPGRAAQSSTEAQPAAQALARGMRLPRFSSTVVLSLLIVQTGI
                     LVFLVSRQMPSSPAGRGEHVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWDA
                     LSQASAPALHMAVRDLIRSVFLCDMDVFDAYLPWRRNISDLFQWAVSRALCSPPVCDA
                     FARGNISSEEVCKPLCATRPFGLAQEACSSYSHVVLKEVRFFNLQVLYPLLSDPALNL
                     RIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPRLRVVSEVCRSHVRIA
                     EVALHKPPPFLQDRYRLVRYEDLARDPLTVIRELYAFTGLGLTPQLQTWIYNITHGSG
                     PGARREAFKTTSRDALSVSQAWRHTLPFAKIRRVQELCAGALQLLGYRPVHSELEQRD
                     LSLDLLLPRGMDSFKWASSTDKQPES"
     misc_feature    672..1268
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
     misc_feature    672..1268
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
     exon            183..2054
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacggtc cgggttgggg aggatagagg agctccaggc caactggctg cttccttgct
       61 cggctcccgc cctggctccc gccggcggcc ccaggcaaag agccaccact cactgagctg
      121 ctcattgtat gcgccccggg cgggcagcgc agagcagcac agaagcgcag ccggcagcgc
      181 aggctctagc cagaggcatg cggctacccc gcttctccag cactgtagtg ctttcgctcc
      241 tgatagtgca gaccggcatc ctggtcttcc tggtctcccg gcaaatgcca tcatccccag
      301 caggccgtgg ggagcatgtg catgtgctgg tgctgtcctc ctggcgctcg ggctcgtctt
      361 tcgtgggcca gctcttcagc caacacccgg atgtcttcta cctgatggag ccagcttggc
      421 acgtgtggga tgcgttgtcg caggccagtg cccccgcgct ccacatggcc gtgcgcgacc
      481 tgatccgttc agtgttccta tgcgacatgg acgtgttcga tgcctacctg ccctggcgcc
      541 gcaatatctc ggatctcttc cagtgggcag tgagccgggc gttgtgctcg cctccagtct
      601 gcgacgcctt cgctcggggc aacattagca gcgaggaggt gtgtaagcct ctgtgtgcaa
      661 cgcggccctt cggcctggct caggaagcct gcagctccta cagtcacgta gtgctcaagg
      721 aggtgcgctt ctttaacctg caggtgctct accccctgct cagcgaccct gcgctcaacc
      781 tgcgcatcgt gcacctagta cgcgacccgc gggccgtgct acgttcccga gagcagacag
      841 ccaaggcgct ggcacgggac aatggcatcg tcctgggtac caacggcaca tgggtggagg
      901 cagacccccg gctgcgcgtg gtcagcgagg tgtgccgcag ccatgtgcgc atcgcagagg
      961 tagcattgca caagccgccg cctttcttgc aagatcgcta ccgcctggtg cgctatgaag
     1021 acctggcccg agacccgctc accgtaatcc gtgaactcta tgccttcact ggtctgggtc
     1081 tcacgccgca gctccagact tggatttaca acatcaccca tggctcgggg ccaggcgcac
     1141 gccgtgaggc cttcaagacc acatccaggg atgcgctcag tgtatcccag gcttggcgcc
     1201 acacactgcc ctttgccaag attcgccggg tccaggagct gtgcgcgggt gcactgcagc
     1261 tgctcggtta ccggcctgtg cactcggagc ttgagcaacg ggacctctct ctggacctcc
     1321 tgctgccacg aggcatggac agtttcaagt gggcgtcgtc cacggataag caaccggaat
     1381 cttagaattt tagcggagag agccagctct gacattaggg tctattggag tatgataaag
     1441 ggcttggaga actcaaaagc aagtgaccgg aagtgggagt ggtcttgccc tgtatcagga
     1501 aaggatggag tccaaatccc acatttcgtt ttgtccagat tatagttttc ctttgggtcg
     1561 gtcctttagg atttggattc ccatcaagta ctgtcgatgg aaagtgaaag tgtccacttc
     1621 ctgaggtcac agaggcagcc agacacctac tgaagcactt cctttctctt tgactttctc
     1681 ccccctttgg tcataccatg gtgtcccagg tctggtcagg agtggaggaa gggcgctgct
     1741 atggggtggc tcctaaaatt tgtgcacctg cccctcattg gctcgccctg atgtctgccc
     1801 atctctgtgc cctagccccc ctggacagtt atgtgcacgg tcaaggagga atcggagagg
     1861 atgcctctgt agtttcccct tagattctct gcctgacctt ctaggaggga gccttggcgt
     1921 ataccccatg cctgaggacg acggcttttt aatgaacctt tggtttgtcc tgagatgaaa
     1981 gatcctaatt atggaaataa acatcataaa tacgctgcgt gatccagatt agagcctatc
     2041 gcatgtgaaa agca
//
LOCUS       NM_021687              12567 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4),
            transcript variant 2, mRNA.
ACCESSION   NM_021687
VERSION     NM_021687.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12567)
  AUTHORS   Zhang,S., Hu,S., Dong,W., Huang,S., Jiao,Z., Hu,Z., Dai,S., Yi,Y.,
            Gong,X., Li,K., Wang,H. and Xu,D.
  TITLE     Prenatal dexamethasone exposure induces anxiety- and
            depressive-like behavior of male offspring rats through
            intrauterine programming of the activation of NRG1-ErbB4 signaling
            in hippocampal PV interneurons
  JOURNAL   Cell Biol Toxicol 39 (3), 657-678 (2023)
   PUBMED   34189720
REFERENCE   2  (bases 1 to 12567)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   3  (bases 1 to 12567)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12567)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   5  (bases 1 to 12567)
  AUTHORS   Chen,J.L., Zhou,X., Ding,H.L., Zhan,H.L., Yang,F., Li,W.B.,
            Xie,J.C., Liu,X.G., Xu,Y.C., Su,M.Z., Liu,B.L. and Zhou,X.F.
  TITLE     Neuregulin-1-ErbB signaling promotes microglia activation
            contributing to mechanical allodynia of cyclophosphamide-induced
            cystitis
  JOURNAL   Neurourol Urodyn 38 (5), 1250-1260 (2019)
   PUBMED   30989724
REFERENCE   6  (bases 1 to 12567)
  AUTHORS   Carroll,S.L., Miller,M.L., Frohnert,P.W., Kim,S.S. and Corbett,J.A.
  TITLE     Expression of neuregulins and their putative receptors, ErbB2 and
            ErbB3, is induced during Wallerian degeneration
  JOURNAL   J Neurosci 17 (5), 1642-1659 (1997)
   PUBMED   9030624
REFERENCE   7  (bases 1 to 12567)
  AUTHORS   Riese,D.J., Kim,E.D., Elenius,K., Buckley,S., Klagsbrun,M.,
            Plowman,G.D. and Stern,D.F.
  TITLE     The epidermal growth factor receptor couples transforming growth
            factor-alpha, heparin-binding epidermal growth factor-like factor,
            and amphiregulin to Neu, ErbB-3, and ErbB-4
  JOURNAL   J Biol Chem 271 (33), 20047-20052 (1996)
   PUBMED   8702723
REFERENCE   8  (bases 1 to 12567)
  AUTHORS   Cohen,B.D., Green,J.M., Foy,L. and Fell,H.P.
  TITLE     HER4-mediated biological and biochemical properties in NIH 3T3
            cells. Evidence for HER1-HER4 heterodimers
  JOURNAL   J Biol Chem 271 (9), 4813-4818 (1996)
   PUBMED   8617750
REFERENCE   9  (bases 1 to 12567)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   10 (bases 1 to 12567)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 7, 2025 this sequence version replaced NM_021687.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY375306.1, AF041838.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               JAXUCZ010000009.1  78045492-78046365   c
            875-1026            JAXUCZ010000009.1  77652717-77652868   c
            1027-1213           JAXUCZ010000009.1  77486353-77486539   c
            1214-1348           JAXUCZ010000009.1  77329931-77330065   c
            1349-1414           JAXUCZ010000009.1  77297827-77297892   c
            1415-1533           JAXUCZ010000009.1  77277927-77278045   c
            1534-1675           JAXUCZ010000009.1  77274999-77275140   c
            1676-1789           JAXUCZ010000009.1  77272312-77272425   c
            1790-1916           JAXUCZ010000009.1  77265268-77265394   c
            1917-1990           JAXUCZ010000009.1  77258501-77258574   c
            1991-2081           JAXUCZ010000009.1  77257410-77257500   c
            2082-2281           JAXUCZ010000009.1  77250459-77250658   c
            2282-2414           JAXUCZ010000009.1  77241085-77241217   c
            2415-2508           JAXUCZ010000009.1  77233398-77233491   c
            2509-2663           JAXUCZ010000009.1  77226370-77226524   c
            2664-2738           JAXUCZ010000009.1  77218392-77218466   c
            2739-2871           JAXUCZ010000009.1  77189578-77189710   c
            2872-2994           JAXUCZ010000009.1  77186058-77186180   c
            2995-3093           JAXUCZ010000009.1  77182095-77182193   c
            3094-3279           JAXUCZ010000009.1  77138089-77138274   c
            3280-3435           JAXUCZ010000009.1  77019981-77020136   c
            3436-3511           JAXUCZ010000009.1  77017863-77017938   c
            3512-3658           JAXUCZ010000009.1  77015123-77015269   c
            3659-3756           JAXUCZ010000009.1  77012776-77012873   c
            3757-3927           JAXUCZ010000009.1  77010899-77011069   c
            3928-3975           JAXUCZ010000009.1  76984767-76984814   c
            3976-4273           JAXUCZ010000009.1  76983351-76983648   c
            4274-12567          JAXUCZ010000009.1  76973386-76981679   c
FEATURES             Location/Qualifiers
     source          1..12567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32-q33"
     gene            1..12567
                     /gene="Erbb4"
                     /note="erb-b2 receptor tyrosine kinase 4"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
     exon            1..874
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    778..780
                     /gene="Erbb4"
                     /note="upstream in-frame stop codon"
     CDS             793..4719
                     /gene="Erbb4"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor tyrosine-protein kinase erbB-4;
                     c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor
                     tyrosine kinase; v-erb-a erythroblastic leukemia viral
                     oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia
                     viral oncogene 4"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-4 isoform
                     2 precursor"
                     /protein_id="NP_067719.2"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
                     /translation="MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQ
                     QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENL
                     RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
                     IHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
                     GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
                     HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
                     DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVF
                     RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
                     KEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCS
                     NDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGL
                     LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG
                     CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKK
                     KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
                     GETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQL
                     MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
                     VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
                     TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
                     EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
                     PPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTI
                     PEAPVAQGATAEMFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERNPRAELD
                     EEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVN
                     EPLYLNTFTNALGNAEYMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEY
                     STKYFYKQNGRIRPIVAENPEYLSEFSLKPGTMLPPPPYRHRNTVV"
     sig_peptide     793..867
                     /gene="Erbb4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     868..4716
                     /gene="Erbb4"
                     /product="Receptor tyrosine-protein kinase erbB-4.
                     /id=PRO_0000016675"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3)"
     misc_feature    955..1293
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    955..1293
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1204..1206
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1312..1314
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1348..1788
                     /gene="Erbb4"
                     /note="Furin-like cysteine rich region; Region:
                     Furin-like; pfam00757"
                     /db_xref="CDD:395614"
     misc_feature    1348..1788
                     /gene="Erbb4"
                     /note="Furin-like cysteine rich region; Region:
                     Furin-like; pfam00757"
                     /db_xref="CDD:395614"
     misc_feature    1549..1551
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1864..2226
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1864..2226
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1864..1866
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2020..2022
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2209..2211
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2275..2277
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2296..2694
                     /gene="Erbb4"
                     /note="Growth factor receptor domain IV; Region:
                     GF_recep_IV; pfam14843"
                     /db_xref="CDD:464344"
     misc_feature    2296..2694
                     /gene="Erbb4"
                     /note="Growth factor receptor domain IV; Region:
                     GF_recep_IV; pfam14843"
                     /db_xref="CDD:464344"
     misc_feature    2434..2436
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2518..2520
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2650..2652
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2716..2847
                     /gene="Erbb4"
                     /note="Transmembrane domain of ErbB4, a Protein Tyrosine
                     Kinase; Region: TM_ErbB4; cd12092"
                     /db_xref="CDD:213053"
     misc_feature    2716..2847
                     /gene="Erbb4"
                     /note="Transmembrane domain of ErbB4, a Protein Tyrosine
                     Kinase; Region: TM_ErbB4; cd12092"
                     /db_xref="CDD:213053"
     misc_feature    order(2716..2721,2725..2736,2743..2748,2755..2760,
                     2767..2772,2779..2784,2791..2793,2803..2805)
                     /gene="Erbb4"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213053"
     misc_feature    order(2716..2721,2725..2736,2743..2748,2755..2760,
                     2767..2772,2779..2784,2791..2793,2803..2805)
                     /gene="Erbb4"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213053"
     misc_feature    2746..2817
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     transmembrane region"
     misc_feature    2818..2844
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    2920..3828
                     /gene="Erbb4"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     HER4; Region: PTKc_HER4; cd05110"
                     /db_xref="CDD:173655"
     misc_feature    2920..3828
                     /gene="Erbb4"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     HER4; Region: PTKc_HER4; cd05110"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375,3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="active site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375,3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="active site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375)
                     /gene="Erbb4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375)
                     /gene="Erbb4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    3370..3447
                     /gene="Erbb4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173655"
     misc_feature    3370..3447
                     /gene="Erbb4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173655"
     misc_feature    3415..3417
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    order(3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    order(3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    3886..3897
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PPxy motif 1"
     misc_feature    3895..3897
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    3958..3960
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4240..4242
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4276..4278
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4354..4356
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4396..4398
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4516..4518
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4564..4566
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4642..4644
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4684..4695
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PPxY motif 2"
     misc_feature    4708..4716
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PDZ-binding"
     exon            875..1026
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1213
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1348
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1414
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1533
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1675
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1789
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1916
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1990
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2081
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2281
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2414
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2508
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2663
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2738
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2871
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2994
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3093
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3279
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3435
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3511
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3658
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3756
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3927
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..3975
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4273
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..12567
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaaagc ctggctggtt gcgtggaggg ttgtttgatt cccaccccca ctcccctctt
       61 tttttctttc ttttcttttc ttttcttttt taaaaaatct ttctccctga gtcttattaa
      121 tttctctgtg gggctgcggc tggagaccgc ggagcgttgg aaatgacgct cggagcttta
      181 attactgcaa tggctggaca agtgtgagga aagctgacag tggaaaaaaa ggggcacagg
      241 atcggggaga aggaaagaag caccccccct ccttttccct ccagatttgg acaggagatg
      301 caaggagact gaagagagag ctgaacatag cctggttttg gggggagagg ccggaaccct
      361 gccgcctctt cgcaatcaac tttttttgga agcctttatt ccccctcttt ctttttattg
      421 ttgaccaacc agtgagaagg agagagagcg agcgagaaag tgaggagtga acgggcgagc
      481 agaggatcac tccggaaact agctgtacgg ttgtgctcgg agcaccagcc gcacagtcgc
      541 gcacactccc atccgcgcgc cctccttcgc ggccccttgc tgggtccgcg ggtccccggg
      601 tcctggaagc cgccaccagc gccgactggc tcgccaaccc cgggaagccc gtgcacagag
      661 cgcgccgcgc ccgcccccct cgcgcccccc acgcgctccc ggctgagggg gggagatctc
      721 ctccgcgtgc ccgcaagtgg ctatggtatt tggacatgta attgtcagcg cgggatctga
      781 gacttgccaa aaatgaagct ggcgacggga ctgtgggtct gggggagcct tctggtggca
      841 gccaggaccg tccagcccag cgcttctcag tcagtgtgtg ccggaacaga gaacaaactg
      901 agctctctct ctgatctgga gcagcagtac cgagccttgc gcaaatacta tgaaaactgc
      961 gaggtagtca tgggcaacct ggagatcacc agcatagagc acaaccggga cctctccttc
     1021 ctgcggtcta tccgagaagt cacaggctat gtacttgtgg ccctcaacca gtttcgttac
     1081 ctgcctctgg agaatttacg cattattcgt gggacaaaac tgtatgaaga tcgctatgcc
     1141 ttagcaatat tcttaaacta caggaaagat ggcaactttg gacttcaaga actgggatta
     1201 aagaacctga ccgaaatact aaatggtgga gtctatgtag accagaacaa attcctatgt
     1261 tatgctgata ctatacactg gcaagatatt gttcggaatc catggccttc caacatgact
     1321 ctggtgtcaa caattggaag ttctggatgc ggaagatgcc ataagtcttg cactggtcga
     1381 tgctggggac ccacagaaaa tcactgccag accttgacca ggactgtgtg tgctgaacaa
     1441 tgtgatggca ggtgctatgg accctacgtc agtgactgct gccatcgaga atgtgccgga
     1501 ggctgctcag gaccaaaaga cactgactgc tttgcctgca tgaacttcaa tgacagtgga
     1561 gcctgtgtta ctcagtgtcc ccaaacgttc gtctacaatc caaccacctt tcaactggaa
     1621 cacaacttca atgcaaagta cacatatgga gcattctgtg ttaagaaatg tccacataac
     1681 ttcgtggtag attccagttc ttgtgtacga gcctgcccta gttccaagat ggaagtcgaa
     1741 gaaaatggaa ttaaaatgtg taagccttgc actgatattt gccccaaagc atgtgatgga
     1801 atcggcaccg gatccttgat gtctgctcag actgtggatt ccagtaacat tgacaaattc
     1861 ataaactgca ccaagatcaa cgggaatctc atctttcttg tcactggcat tcatggtgac
     1921 ccttacaatg ctattgacgc catagaccca gagaaactga atgtctttcg gacagtcaga
     1981 gaaataacag gtttcctgaa catacaatct tggcccccaa atatgacaga tttcagtgtt
     2041 ttctccaacc ttgtaaccat tggaggaaga gtcctctaca gtggtctctc attgcttatc
     2101 ctcaaacaac aaggtatcac ttcactacag ttccagtctc tgaaggaaat cagtgcgggc
     2161 aatatctaca tcacggacaa cagcaacctg tgttattacc acaccatcaa ctggacaaca
     2221 ctgttcagca ccgttaacca gaggatagtg atccgagaca acaggagggc tgagaactgt
     2281 actgctgaag ggatggtgtg taaccacctg tgttcaaatg atggttgttg gggacctggg
     2341 ccagaccagt gtctgtcatg tcggcgcttc agcaggggaa agatctgtat agagtcctgc
     2401 aacctttatg atggggagtt tcgagagttt gaaaacggct ccatctgtgt tgagtgtgac
     2461 tcccagtgtg agaaaatgga agacggactc ctcacatgcc atggaccggg acctgacaac
     2521 tgtacaaagt gttctcattt taaagatggt cctaactgtg tagagaaatg tccagatggc
     2581 ctacagggag caaacagttt catatttaag tacgcagatc aggatcggga gtgccaccct
     2641 tgccatccaa actgcaccca ggggtgtaac ggtcccacta gtcatgactg catttactac
     2701 ccatggacgg gccattccac tttaccacaa catgctagaa ctccactgat tgcagccgga
     2761 gtcattggag ggctcttcat cctggtcatc atggctctga catttgccgt ttatgtcaga
     2821 aggaagagca tcaaaaagaa acgcgctttg agaagattcc tggagacaga gctagtcgag
     2881 cccttaaccc ctagtggcac agcacccaat caagctcaac ttcgaatttt gaaggaaaca
     2941 gagctaaaga gggtaaaagt ccttggctcg ggagcatttg gaaccgttta taaaggaatc
     3001 tgggtgcctg aaggtgaaac tgtgaaaatc cctgtggcta ttaagatcct caatgagaca
     3061 actggcccca aagccaatgt ggagttcatg gatgaggcac tgattatggc aagtgtggat
     3121 cacccacacc tagtgcgttt actgggtgtg tgtctgagcc ccactatcca gttggttact
     3181 cagttgatgc cacatggctg cctactggaa tatgtccacg aacacaagga taacatcgga
     3241 tcacagctgc tgttgaactg gtgtgtccag attgctaagg gaatgatgta tctggaggaa
     3301 aggcggcttg ttcatcggga tctggcagcc cgcaatgtgt tggtgaaatc tccaaatcat
     3361 gttaaaatca cagactttgg actggcccgg ctcttggaag gagatgaaaa agaatacaat
     3421 gctgacggtg gcaagatgcc aattaaatgg atggctctgg aatgtataca ttataggaaa
     3481 ttcacacatc aaagcgatgt ttggagctac ggtgtcacta tatgggaact gatgaccttt
     3541 ggaggaaagc cctatgatgg aattccaacg cgagaaatcc ctgacttatt agagaaggga
     3601 gagcgtttgc ctcaacctcc catctgcact attgacgttt acatggtcat ggtcaaatgt
     3661 tggatgatcg atgctgacag cagacctaaa ttcaaagaac tggctgctga gttttcaagg
     3721 atggctagag accctcaaag atacctagta attcaggggg atgatcgcat gaagcttccc
     3781 agtccaaacg acagcaaatt cttccagaat ctcttggatg aagaggattt ggaagatatg
     3841 atggacgctg aggaatattt ggtcccccag gctttcaata tcccacctcc tatctacaca
     3901 tccagaacaa gaattgactc caataggagt gaaattggac acagccctcc tcctgcctac
     3961 acccccatgt cgggaaatca gtttgtgtac caggatgggg gtttcgctac acaacaagga
     4021 atgcccatgc cctaccgagc cacaaccagc accataccag aggctccagt cgcccagggt
     4081 gcaacggctg agatgtttga tgactcctgc tgtaatggta ccctgcgaaa gccagtggta
     4141 ccccacgtcc aagaggacag tagcactcag aggtatagtg ccgaccccac agtgttcgcc
     4201 ccagaacgga accctcgagc agaactggat gaagaaggct acatgactcc catgcatgac
     4261 aagccaaaac aagaatatct gaatcctgtg gaagagaacc cttttgtgtc ccggaggaag
     4321 aatggagacc ttcaagcttt agataatcca gagtatcaca gcgcttccag cggtcccccc
     4381 aaggcagagg atgagtacgt gaatgagccc ctttatctca acaccttcac caacgccttg
     4441 ggaaatgcag agtacatgaa aaacagctta ctgtctgtgc cagagaaagc caagaaagca
     4501 tttgacaacc ccgactactg gaaccacagc ctgccacccc ggagcactct tcagcaccca
     4561 gactacctgc aggaatacag cacaaaatat ttttataaac agaatggacg gatccgccct
     4621 attgtggcag agaatcctga gtacctctca gagttctcgc tgaagccagg cactatgctg
     4681 ccccctccgc cctacagaca ccggaatact gtggtgtgag ctcagctaga gtgttaggtg
     4741 gagaaacaca cacccgctcc atttcccttc tccctcctct ttctctggca gtcttccttc
     4801 ttctcccaag gccagtagtt ttgacacttc cgagtggaag ccgtagagac gcaatgatag
     4861 ttccgtgctt acctaacttg aatattagaa ggaaagactg aaagagaaag acagaggggc
     4921 acacactgtt tcttcatttc ttcatatggg ttggttaaca gagtgtctgt cagagctaga
     4981 gaaggtctag gaagtgtaag gcaataccaa taccgcctgc tgtcaaagag ccccatcttt
     5041 gttctctttg cactctgcac tctctccctc cttctctccc tgtccccatc tccctttaat
     5101 ctatcaatgc tggtgatgat cggaagccca gactctgttc taatctgtag ccatagtctt
     5161 gtgcatattc aagcatccct gaaatcattc taaggcttcc attagaacaa aaagataagc
     5221 agttggacac catttgatag taactgagat tgagaagcca atttctttct ccaatagttt
     5281 ctttcttggc aagtaagaat ggccaatcca gcttttgtga attttaaatc tccattatag
     5341 ttataactgg caattatgct tggaaggcat ctctgtgtac ttcttttcaa ttttggtttg
     5401 ctttggccta ttcctttata tcagttgctc cccttttggc tgcagtttct aattgtaaag
     5461 aggtttacat aaaggcctct tgacagactt caaacaaaaa catatgatac gatgtagaga
     5521 ttgttatttt aaatcattca gtccttaaaa ctagaagaga aagccaagat agtagtaaaa
     5581 aatagtatca aaactagatc tcatgtttca cactactgag tttcgtcttc cctttcgttt
     5641 tcattcttta ccattttatt cttcccccag aaggcttgac aaggcagtgg gaatcttagg
     5701 agtagaaggg atgctaagaa acaggtctgt gtggttcaca aaactactga aactttcagg
     5761 gtggtcccgt gggggatcca tgcagtggga gaaacactgg attgggtacg tctacatgga
     5821 aggtactcag aaatgtagtt tgcacttaag ctataatttt atttgttctt tttctgaaca
     5881 ccactttgga tttttgaatg aagcaatatg gaagcaacca gcagattaac taatttaagt
     5941 acttcatttt aaaaaaaaaa aaggatgtaa gataaagaca gactgtggaa ataccaaacc
     6001 aagccaatta ggactttgga acagtaccca gggattgtgg tgagagggtc agcacattac
     6061 cttcatatga tgtgacattt gctgtgtaag gaagtatgtt aagtttatac tctctgtgtg
     6121 aacggatgca agttaaggac tggcgtgaat tccatagaga ttctggaatg acattctgtt
     6181 tatattgact aggtgactta actcttcaca cctaagttgc tataattaaa agcaaaccat
     6241 caacatttga agcctatgaa taggtccatg cttgagttaa aagttgtaaa taaacatgaa
     6301 aacccttctc acgcaattat tttattatcc agtatattaa tcttttaata atttatgtaa
     6361 tgactctttc ttcatatact accatactat gtccaggttg tagatccctc tgataggttt
     6421 aattttgaaa aagcacctat agtgttaagg ttagtgatgg ggacagtgac aaatgaatct
     6481 ttaggaaata aggaaacaat acatctctct tttctacaaa attctcctcc aagtctttta
     6541 ggtttttaaa catttctttc tactgttaaa gttttgagag aacattagat tcactagcaa
     6601 aaaaataatc aattagatta aaaatcttct cagtaaaata gagagtactt aagggagaaa
     6661 attctcaagg gagtttacgt ttctacctat tttgaaaaag taaacccgtg catccaaatc
     6721 tagaatcatt caactgatat taaaagtcta ctgaaagtat gtgggggata agtgaaacca
     6781 tccctgactt caaattttaa caatctagat ttatttgctg tgacattctt atttctctat
     6841 gagtccaagg aatcagattg tattagctat tttgtgaatg gatacatgga acattttgta
     6901 aaagttttca gaagtcattg ggatatattt taaacatcct tcaagctact gaagatgaca
     6961 aatataatcg cctctgtgtt ctttctcaga cacaaaccgg accacatgag cattacatca
     7021 ctggcaaact gatatatctg gagtgttgcc ataaaatcag ggcaaactcc tgggaagtgt
     7081 tgggtttgtt ctcttcttca gggaagagat ggcaagcgaa ctgaaagtga gagttggaaa
     7141 gagcagaggg gtctgtgaga tcctgtctag aggaatttag ccatgaattt accagatgca
     7201 gaatgatccg gggggccaca gcctgaaaac ccaaagttca ccccaattca gaggcatcca
     7261 ctaagacaag ggaccttata taagtaccta tttcccttaa agtaagcctc tgttagtaaa
     7321 taaatctata cctaaccatt actgtcagca ccttgaaatg ctacaaggac tttttcttat
     7381 cacttaaaat atccccgtgg cttctagtgg gataaagaaa gcaattattt cattagtaaa
     7441 tgaaaggaga taatctccta gctgttaatt caatgtaaat gtagtcaatg agggttgccc
     7501 ttttcttccc tataagcaca ggatttgcag ttccactcat cttcccctag atgcaggttt
     7561 gagggagaat gaccccaagt gccattttta tcattccttt gtatgacttt ttaatatata
     7621 cttgatttca gtttttctgg tatttcttgt ttatttagat ttgactacct aggccctgaa
     7681 ttctagggga cattattcaa gtatgtatta atgggacaac aagtaggaat catggaggat
     7741 gtacactcat ttgcttaaga gaacaacatg tttaaccccg taaaatgaaa ctgtaaaaca
     7801 ccaatactaa gcttgtagat tatggaatag caggtcccaa gactgggcag caccaatcaa
     7861 aatatgcagg atctatttgt aaagcagtaa aattaatgtt aaatttgagc ttcttatctt
     7921 ttttaaatca tcaaattgta acgatcaagc ttatcttggg aaatcctact ttcagggagg
     7981 aaaatttttt tagccactta aagaagccag tcttgagcag agaaaagttg ggggaagttc
     8041 agagctacca aagtgctgct attcaagcaa agttgataac aaagctatgc ccagctgaac
     8101 taactacatt cgcagcacag attaggtatg gatcactctc tctagaagca ttcttgaaga
     8161 gatgtggaaa caatgcaaat tgcaaactat taaaaaaaaa gaaagatgga agacttacta
     8221 aaacaaacaa acaaacaaaa aaaaccaaaa aatggaagac tcactaagta tgaacctgct
     8281 tttcataggt cacgaagaat gtctgatagg ccctatcttg aaaaagaaat gggggacttc
     8341 taagtgagac actgtcatgt cctatacctt tggagaatga cacatattgt caatggtgga
     8401 gaaaaaagga gggatatgag gcttcatgaa tagatgaagt tagtggaata agtggtggag
     8461 ttcctgaagg gtcaaaacta gaaagagtaa acaaacgtgt ttatgcctgt gcctgacaca
     8521 gaaagttgta aatacaagat tctcttgaac gggtttaacc tttatttaaa aactggaatt
     8581 tgttgtccac ctgtaagtgt tgattattta actagtacac gtagctcata aggtaataaa
     8641 aatggtgacc atgcaagcat gtgtacaatt ggacacaatc atgacaatgc tctaagacat
     8701 agaattcact aggctagcag atgttaaatg ctttcaatag taatgaccaa attaaattag
     8761 aaaaactagc aaggagcata aaataacaat aaaattcaga ctttgaaaac gtaggatgga
     8821 ttttgcgtag taaataagtt tcccatttaa atggttattt gttggagtta gcagatagca
     8881 ggaatagtga tgtttcacgt gtaaagactg gctttatagt gctacagtcg atttttctca
     8941 tgtcctctta gcccttcgtt tcattttaat tcattaagta taaagtgatg ctgtatttgg
     9001 ggactctggt ttgcagatat cactttgaag ggtttaacag gcaaataaac cacaggagaa
     9061 tttaagagac ctttataatg aataatggaa attttcaaaa agggtctatt gcctttcgca
     9121 gttgcggaaa aaaaatgtgt gcttacccca gtggtttaga aagcaagcaa aatatttaat
     9181 ttgtgaagtg tcctttcttt tcctaccatc ttgcagatat aaccaatatg gaacccattt
     9241 tcacttttat tgttactatt tttttgataa atagatgcct aaccaagaat tttaagctat
     9301 tctattggtg ttcttttgga ctctagtttt ttttaactgt ttatttgtta tggagcaaat
     9361 aggaaatcca agagcagagc tatgagcagt taaaaagcca gacaaaccaa tttctactgc
     9421 atgtatcatg ggcacagaat ccggttgtgc ctctctgtat ctgagggaca gtcttatact
     9481 ggtgtagaca cgcaatggca ggctgtcatc ccctgctgac cattggttca tgaccaaatg
     9541 atatatgaat ataagtgtga atccgacata attttaaaag atctttgaca gttcagacct
     9601 tctccatgat gactctaaga tgaggccagc atttacattt tctggttgga cacctttttc
     9661 taagcccaga gttgcctttg aaggtgttct ctctcctgtt ataaacatga agatttgaac
     9721 attgtatcag gccaggtgcc cttgtgtttg tgtatataaa tccatccaac acaagacact
     9781 gctttgcttc tccactaaat gaaacttgat aaaatgttaa gactttccga ctctctctgt
     9841 tcaagtccca ctcacttaat caggagacaa aagtgtgtgg tgtgtctcac ctcactcctg
     9901 gccgagagat ggtttaggca cagaaaaatg cttctagtgc cacaggctgt aaagactata
     9961 taagccccaa tgttaaggga agatatccat gcctcccctg gaaagaaatc ccttgaaagc
    10021 caactttgca agtaagtgat caccttgtca taaataggac attgtgtttc cctcggaacg
    10081 tttagaggaa aatagcatct ttactttccc acccccaact ctcacaatgc ctttgccatg
    10141 tttttttcta tcacaagttc aaagtggctt tcctggggta ccactttctt aagccatagt
    10201 ggatctctga agaaccacat cctcttctga aacactgacc cagcctttgc ctccaaatgc
    10261 ctgatggttt tttttccatt aaaatatcta accactctag aaggtgttta aattgcttct
    10321 caaacaaaag acagcacaaa agatatatat attgtttagg gtgttaagat tgttttttcg
    10381 tgacaattga ttctatcact gtgggcttct ctataggatt ttaagattag ttagctctgt
    10441 aatgaatctt aagactctca ttgtatgtac atacacttct agatcttaca ttaatctttc
    10501 catgaaaact atatatgtgt atatatagtt tttatgtatg tatataaaac taagttattg
    10561 ccgccaacta acttatttcc tttgatcacc ttattttatt tctgatataa atattttaca
    10621 gctgctagag ttttggggtt tttttttcca aatgaagagt tttattatca cgaaggtaaa
    10681 ggcaattcac ctgtgcgaac ctcctgtgac tcttgttgga acatccatct atctaacaaa
    10741 tttataataa gcaccgtttc actgtaatga aagtctgtgt tgactgacag aactctatct
    10801 actctttctc tactttagga ggaatttttc cttttaatac tttagtgtgt cttccccttg
    10861 tcactaaaag tgtttatatt tgtatagata aacaagtaca agaaaacgag cttttgcatc
    10921 tgtaggcaat agtcgaattt gtccaaacca ctttgtcttt actgctactt ttatccctga
    10981 tatgttgatg ttttccccgg gcctgttacc tttttgaaga aaagcaaacc acactccctc
    11041 tctattgaca gaaatccgat gttcaagtat catttccagt gtttttcggt taatggaggg
    11101 gttgcgtcat tttccttaat gtaagagtca tctccctgta tagttcttga tctctcaggg
    11161 gctgggagtg gggagtgagg gaacagctac catagaactc taagaaccaa gaacccttat
    11221 ggaattactc cggaatcagc tatgaaagtt attttctaac tgtagatata tgtaagccgt
    11281 tctttttaag taaggtactt tgaaatatgt agcataaact ggtactgctg ttaaatgggt
    11341 cgactattaa actgagcagc tgtgcaaggg gcagttaact ttgaatgcac accttcctgg
    11401 ctagcttgta tccatctcat cacctgagca ccatggcctt cattgctgca caccaagagt
    11461 gtttctccac atgctctggc tgcttgatca tctctctctc agtatcatta gaacaagatc
    11521 aaatgtaaat ggtattaatg cgcaagataa ttcatggcac acgctaaact aggtcacatt
    11581 aaatttttca aaacttcatc tcgtgcacgc accacagtag ttaactaaga tcagtttggg
    11641 tgacaaaggg aggcaatttg cagaagaggc agagttatgt ctgttcccta attttcttga
    11701 catgtaaaca gaaaaccagc tctctttcct ctgaagaatc atcaaaggac agggctgtta
    11761 aaaaaaaaaa aaaacacaac ttgctggtaa gccatcagtg tttcatttaa atcccagcat
    11821 tcaaagttag ctgccttttt tgaaacaaac aaacaaaaac tactactgta tgtttgaaaa
    11881 tgtgaatagt atttttatag cttgttaaag acatggctag ctgcatttgt aaatagggat
    11941 aatgttgctt tgattttctt tgatgagcat ctttatttgg aacataattg tctttagggt
    12001 tgatttgtat ataagtaatt ggcttgtgat tgtttctctt ttggttagaa gttatcgttt
    12061 tgacattacc tgtgattctg tgttcagcac tattgtgatg tgtccaacct ctgcactcgc
    12121 ttacacaata ggatatgcca attgtgtgtg gtgaaatgtt attttcattt ttttctattt
    12181 tatctatgaa ggattatgca cttaacacat actaactttt ttaatgttag gtctattttt
    12241 agtataattt cccgattctt ctccaaccct tcagcttctt ttccctcctt tccctatttt
    12301 ctgttgttat agaggatgag ggagaaaatg tattttaaat ggatgtaatt aggctttttg
    12361 aggtagttct caaggatcct cttttgactc ttgggaaaga attgtgcgtg cacaaggcaa
    12421 atatagaatg cgagctgctt tgcctcattc cgtactgatc atcccaaatg aacaatttga
    12481 aaactgttct gcctttttgt tacatgaatc tgtcagaaat atatttttaa tttaatataa
    12541 acgaaattca ataaaatatg aaacaaa
//
LOCUS       NM_001106321            5101 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus LDL receptor related protein 5 (Lrp5), transcript
            variant 2, mRNA.
ACCESSION   NM_001106321 XM_001067386 XM_215187
VERSION     NM_001106321.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5101)
  AUTHORS   Ubels,J.L., Lin,C.M., Antonetti,D.A., Diaz-Coranguez,M.,
            Diegel,C.R. and Williams,B.O.
  TITLE     Structure and function of the retina of low-density lipoprotein
            receptor-related protein 5 (Lrp5)-deficient rats
  JOURNAL   Exp Eye Res 217, 108977 (2022)
   PUBMED   35139333
  REMARK    GeneRIF: Structure and function of the retina of low-density
            lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
REFERENCE   2  (bases 1 to 5101)
  AUTHORS   Ju,S., Lim,L., Wi,K., Park,C., Ki,Y.J., Choi,D.H. and Song,H.
  TITLE     LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in
            Ischemic Myocardium
  JOURNAL   Int J Mol Sci 22 (12), 6581 (2021)
   PUBMED   34205318
  REMARK    GeneRIF: LRP5 Regulates HIF-1alpha Stability via Interaction with
            PHD2 in Ischemic Myocardium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5101)
  AUTHORS   Ubels,J.L., Diegel,C.R., Foxa,G.E., Ethen,N.J., Lensing,J.N.,
            Madaj,Z.B. and Williams,B.O.
  TITLE     Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats
            Have Reduced Bone Mass and Abnormal Development of the Retinal
            Vasculature
  JOURNAL   CRISPR J 3 (4), 284-298 (2020)
   PUBMED   32833527
  REMARK    GeneRIF: Low-Density Lipoprotein Receptor-Related Protein
            5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of
            the Retinal Vasculature.
REFERENCE   4  (bases 1 to 5101)
  AUTHORS   Ergun,S.G., Akay,G.G., Ergun,M.A. and Percin,E.F.
  TITLE     LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated
            microphthalmia
  JOURNAL   Eur J Med Genet 60 (3), 200-204 (2017)
   PUBMED   28111184
REFERENCE   5  (bases 1 to 5101)
  AUTHORS   Huang,W., Li,Q., Amiry-Moghaddam,M., Hokama,M., Sardi,S.H.,
            Nagao,M., Warman,M.L. and Olsen,B.R.
  TITLE     Critical Endothelial Regulation by LRP5 during Retinal Vascular
            Development
  JOURNAL   PLoS One 11 (3), e0152833 (2016)
   PUBMED   27031698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5101)
  AUTHORS   Kato,M., Patel,M.S., Levasseur,R., Lobov,I., Chang,B.H., Glass,D.A.
            2nd, Hartmann,C., Li,L., Hwang,T.H., Brayton,C.F., Lang,R.A.,
            Karsenty,G. and Chan,L.
  TITLE     Cbfa1-independent decrease in osteoblast proliferation, osteopenia,
            and persistent embryonic eye vascularization in mice deficient in
            Lrp5, a Wnt coreceptor
  JOURNAL   J Cell Biol 157 (2), 303-314 (2002)
   PUBMED   11956231
REFERENCE   7  (bases 1 to 5101)
  AUTHORS   Gong,Y., Slee,R.B., Fukai,N., Rawadi,G., Roman-Roman,S.,
            Reginato,A.M., Wang,H., Cundy,T., Glorieux,F.H., Lev,D.,
            Zacharin,M., Oexle,K., Marcelino,J., Suwairi,W., Heeger,S.,
            Sabatakos,G., Apte,S., Adkins,W.N., Allgrove,J.,
            Arslan-Kirchner,M., Batch,J.A., Beighton,P., Black,G.C.,
            Boles,R.G., Boon,L.M., Borrone,C., Brunner,H.G., Carle,G.F.,
            Dallapiccola,B., De Paepe,A., Floege,B., Halfhide,M.L., Hall,B.,
            Hennekam,R.C., Hirose,T., Jans,A., Juppner,H., Kim,C.A.,
            Keppler-Noreuil,K., Kohlschuetter,A., LaCombe,D., Lambert,M.,
            Lemyre,E., Letteboer,T., Peltonen,L., Ramesar,R.S., Romanengo,M.,
            Somer,H., Steichen-Gersdorf,E., Steinmann,B., Sullivan,B.,
            Superti-Furga,A., Swoboda,W., van den Boogaard,M.J., Van Hul,W.,
            Vikkula,M., Votruba,M., Zabel,B., Garcia,T., Baron,R., Olsen,B.R.
            and Warman,M.L.
  CONSRTM   Osteoporosis-Pseudoglioma Syndrome Collaborative Group
  TITLE     LDL receptor-related protein 5 (LRP5) affects bone accrual and eye
            development
  JOURNAL   Cell 107 (4), 513-523 (2001)
   PUBMED   11719191
REFERENCE   8  (bases 1 to 5101)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   9  (bases 1 to 5101)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   10 (bases 1 to 5101)
  AUTHORS   Dong,Y., Lathrop,W., Weaver,D., Qiu,Q., Cini,J., Bertolini,D. and
            Chen,D.
  TITLE     Molecular cloning and characterization of LR3, a novel LDL receptor
            family protein with mitogenic activity
  JOURNAL   Biochem Biophys Res Commun 251 (3), 784-790 (1998)
   PUBMED   9790987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166786.1.
            
            On May 20, 2008 this sequence version replaced NM_001106321.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42-q43"
     gene            1..5101
                     /gene="Lrp5"
                     /note="LDL receptor related protein 5"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
     exon            1..171
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..4883
                     /gene="Lrp5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; low-density lipoprotein receptor-related
                     protein 5"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     5 isoform 2 precursor"
                     /protein_id="NP_001099791.2"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
                     /translation="METAPTRAPPPPPQPLLLLLALCCSLVPAAASPLLLFANRRDVR
                     LVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNI
                     VISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP
                     AHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF
                     IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILS
                     ALYSPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSPREPFYSCACPTGVQLQDNGK
                     TCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDD
                     EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
                     KILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGL
                     ALDLQEGKLYWGDAKTDKIEVINIDGTKRQTLLEDKLPHIFGFTLLGDFIYWTDWQRR
                     SIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATK
                     CGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDF
                     DVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTN
                     RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT
                     LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSD
                     YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCG
                     QLCLAIPGGHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLILP
                     LHGLRNVKAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLS
                     IDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQD
                     HAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANR
                     LTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAV
                     EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD
                     QFACATGEIDCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDAV
                     CLPNQFRCASGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDVPAHSSAIGPVIGI
                     ILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGTPHVPLNFIAPGGSQHGPFPGI
                     PCSKSMMSSVSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPS
                     LYNMDMFYSSNIPSTARPYRPYIIRGMAPPTTPCSTDVCDSDYSTSRWKTSKYYLDLN
                     SDSDPYPPPPTPHSQYLSAEDSCPPSPVTERSYCHLFPPPPSPCTDSS"
     sig_peptide     81..173
                     /gene="Lrp5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    147..722
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    147..722
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    384..506
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    384..506
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    567..689
                     /gene="Lrp5"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    567..689
                     /gene="Lrp5"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    639..767
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    639..767
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    768..893
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    768..893
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    975..1088
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    975..1088
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1176..1298
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1176..1298
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1302..1430
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1302..1430
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1431..1562
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1431..1562
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1563..1691
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1563..1691
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1692..1793
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1692..1793
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1893..2000
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1893..2000
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    <2040..2426
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    <2040..2426
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    2208..2336
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2208..2336
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2475..2594
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2475..2594
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2592..2717
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2592..2717
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2796..2903
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    2796..2903
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    2988..3107
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2988..3107
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3258..3389
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3258..3389
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3390..3518
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3390..3518
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3729..3839
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3729..3839
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3855..3965
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3855..3965
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3870..3872,3900..3902,3933..3938)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3870..3872,3900..3902,3933..3938)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3912..3914,3921..3923,3933..3935,3951..3956)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3912..3914,3921..3923,3933..3935,3951..3956)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3942..3956
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3942..3956
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4041..4145
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    4041..4145
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(4056..4058,4080..4082,4113..4118)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4056..4058,4080..4082,4113..4118)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4092..4094,4101..4103,4113..4115,4131..4136)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(4092..4094,4101..4103,4113..4115,4131..4136)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    4122..4136
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4122..4136
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     exon            172..568
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            569..766
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..963
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1095
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1492
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1664
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1881
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2171
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2398
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2583
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2907
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3107
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3316
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3507
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3717
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3843
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4035
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4146
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4147..4383
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4523
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4621
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..5086
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagccgc gagggtccac cgccgccgcg cgcgccatgg agcccgagtg agcgcgcggc
       61 gctcccggcc gccggacgac atggaaacgg cgccgacccg ggcccctccg ccgccgccgc
      121 agccgctgtt gctgctgctg gcgctgtgct gcagcctagt ccccgctgcg gcctcaccac
      181 tcctgttgtt tgccaaccgc cgggatgtac gactagtgga tgctggtgga gtgaagctgg
      241 agtccaccat tgtggccagt ggtctggagg acgcagctgc tgtagacttc cagttctcca
      301 agggtgctgt gtactggaca gatgtgagcg aggaggccat caaacagacc tacctgaacc
      361 agactggagc tgctgcacag aacattgtca tctctggcct tgtatcacct gatggcctgg
      421 cctgtgactg ggttggcaag aagctgtact ggacagactc agagaccaac cgcatcgagg
      481 tggccaacct caatgggacg tcccgtaagg ttctcttctg gcaggacctg gaccagccaa
      541 gggccattgc cctggatcct gcacatgggt acatgtactg gactgactgg ggggaagcac
      601 cccggatcga gcgggcaggg atggatggca gtacccggaa gatcattgta gactccgaca
      661 tttactggcc caatgggctg accattgatc tggaggagca gaagctgtac tgggctgatg
      721 ccaaactcag cttcatccac cgtgccaacc tggacggctc cttccggcag aaggtggtgg
      781 agggcagcct cactcacccc tttgccctga cactctctgg ggacacactc tactggacag
      841 actggcagac ccgttctatc cacgcctgca acaagtggac aggggagaaa aggaaggaga
      901 tcctcagtgc tctgtattca cccatggaca ttcaggtgct gagccaggag cggcagcctc
      961 ccttccacac gccatgtgag gaaggcaacg gcggctgctc ccacctgtgc ctgctgtccc
     1021 cgagggagcc cttctactcc tgcgcctgcc ctactggtgt acagttgcag gacaatggca
     1081 agacgtgtaa ggcaggggct gaggaagtgc tgctgctggc ccggaggaca gacctgagaa
     1141 ggatctctct ggacacccct gacttcacag acatagtgct gcaagtgggc gacattcggc
     1201 atgccatcgc catcgactat gacccactgg agggctacgt gtactggaca gatgacgagg
     1261 tgcgggctat ccgcagggcg tacctggatg gctcaggtgc gcagaccctt gtgaacaccg
     1321 agatcaatga tcccgatggc attgccgtgg actgggtcgc ccggaacctc tactggacag
     1381 atacaggcac tgacagaatt gaggtgactc gcctcaacgg cacctcccga aagatcctgg
     1441 tgtccgagga cctggacgaa cctcgcgcca ttgtgttgca ccctgtgatg ggcctcatgt
     1501 actggacaga ctggggagag aaccccaaaa tcgaatgtgc caacctagat gggcgagatc
     1561 ggcatgtcct ggtgaacacc tcccttgggt ggcccaatgg actggccctg gacctgcagg
     1621 agggcaagct gtactggggg gatgccaaaa ctgataaaat tgaggtgatc aacatagacg
     1681 ggacaaagcg gcagaccctg ctagaggaca agctcccgca catttttggg ttcactctgc
     1741 ttggggactt catctactgg acagattggc agcgacgcag tattgagagg gtacacaagg
     1801 tcaaggccag ccgggatgtc atcatcgatc aactccccga cctgatggga ctcaaagcag
     1861 tgaacgtggc caaggttgtc ggaaccaacc cgtgtgcgga tggaaatgga gggtgcagcc
     1921 atctgtgctt cttcacccca cacgccacca agtgcggttg ccccataggc ctggagctgc
     1981 tgagtgacat gaagacctgc ataatccctg aagccttcct ggtgttcacc agcagagcca
     2041 ccatccacag gatctccctg gagactaaca acaatgacgt ggccatcccg ctcaccggtg
     2101 tcaaggaggc ctctgcactg gactttgatg tgtccaacaa ccacatctac tggactgatg
     2161 tcagcctcaa gactatcagc cgagccttca tgaatgggag ctcagtggag cacgtgattg
     2221 agtttggcct cgactaccct gaaggaatgg ccgtggattg gatgggcaag aacctctatt
     2281 gggctgacac ggggaccaac aggattgagg tggcccgact ggatgggcag ttccggcagg
     2341 tgctggtgtg gagagacctt gacaacccca ggtcgctggc tctggatcct actaaaggct
     2401 acatctactg gaccgagtgg ggaggcaagc caaggatcgt gcgggccttc atggatggga
     2461 ccaattgtat gacactggta gacaaggtgg gccgggccaa tgacctcacc attgattacg
     2521 ccgaccagcg actgtactgg actgacctgg acaccaacat gattgagtcc tccaacatgc
     2581 tgggtcagga gcgcatggtg atagctgatg atctgcccta cccctttggc ctgactcaat
     2641 atagcgatta catctactgg accgactgga acctgcatag cattgaacgg gccgacaaga
     2701 ccagcgggcg gaaccgtacc ctcatccagg gtcacctgga cttcgtcatg gacatcctgg
     2761 tgtttcactc ctcccgtcag gatggcctca acgactgcgt gcacagcaat ggccagtgtg
     2821 ggcagctgtg cctcgccatc cccggaggcc accgctgcgg ctgtgcttcc cactacacgc
     2881 tggaccccag cagccgcaac tgcagcccgc cctccacctt cttgctgttc agccagaaat
     2941 ttgccatcag ccggatgatc cccgatgacc agctcagtcc ggaccttatc ctacccctac
     3001 acgggctgag gaatgtcaaa gccatcaact acgacccgct ggacaagttc atctactggg
     3061 tggatgggcg tcagaacatc aagagggcca aggacgacgg tacccagccc tccatgctga
     3121 cctctcccag ccaaagcctg agcccagacc gacagccaca tgacctcagc attgacatct
     3181 acagccggac actgttctgg acctgtgagg ccaccaacac catcaatgtc caccggctgg
     3241 atggggatgc catgggagtg gtgcttcgag gggaccgtga cagaccaagg gccattgctg
     3301 tcaatgctga gcgagggtac atgtacttta ccaacatgca ggaccatgct gccaagattg
     3361 agcgagcctc cctggatggc acggagcgtg aggttctctt caccaccggc cttatccgtc
     3421 ctgtggccct tgtggtggac aatgccctgg gcaagctctt ctgggtggat gcagacctaa
     3481 agcgcattga aagctgcgac ctctcagggg ccaaccgcct gaccctggaa gatgccaaca
     3541 tcgtgcagcc agtaggtctg acggtgctgg ggaggcacct ctactggatc gaccgccagc
     3601 agcagatgat tgagcgtgtg gagaagacca ctggggacaa gaggactagg gttcagggcc
     3661 gtgtcaccca cctgacgggc atccatgctg tggaggaagt cagcctggag gagttctcag
     3721 cccatccttg tgcccgagac aatggcggct gctcccatat ctgcatcgcc aagggtgatg
     3781 ggacaccgcg ctgctcatgc ccagtccacc tcgtgctcct gcagaacctg ctgacttgtg
     3841 gtgagcctcc tacctgctcc cctgatcagt ttgcatgtgc cactggtgag attgactgca
     3901 tccctggagc ctggcgctgt gacggcttcc ctgagtgtgc tgaccagagt gatgaggaag
     3961 gctgcccagt gtgctctgcc tctcagttcc cctgtgctcg aggccagtgc gtggacctgc
     4021 gtttacgctg cgatgctgtc tgtctcccca atcagttccg gtgcgccagt ggccagtgcg
     4081 tcctcatcaa gcagcagtgc gattccttcc ccgactgtgc tgatggatct gatgagctca
     4141 tgtgtgaaat caacaagcca ccttctgatg acgtaccagc ccacagcagc gccattgggc
     4201 ctgtcattgg catcatcctg tccctcttcg tcatgggcgg ggtctacttt gtctgccagc
     4261 gtgtgatgtg ccagcgttac acaggggcca gtggtccctt tccccacgag tatgttggtg
     4321 gaacccctca tgtgcctctc aacttcatag ccccaggtgg ctcacagcac ggtcccttcc
     4381 caggcatccc gtgcagcaag tccatgatga gttctgtgag cctggtgggg gggcggggca
     4441 gcgtgcccct ctatgaccgg aatcacgtca ccggggcctc atccagcagt tcatccagca
     4501 caaaggccac actctatcca ccgatcctga acccaccacc gtccccggcc acagacccct
     4561 ccctgtacaa catggacatg ttttattctt caaacatccc atccactgcc agaccataca
     4621 ggccctacat cattcgaggt atggcacccc caacaacacc ttgcagcaca gacgtgtgtg
     4681 acagcgacta cagcaccagt cgctggaaga ccagcaagta ctacctggac ttgaattcgg
     4741 actcagaccc ctacccgccc ccgcccactc cccacagcca gtacctgtct gcagaggata
     4801 gctgtccacc ctctcctgtc actgagagaa gctactgcca cctcttccca ccccctccat
     4861 ccccctgcac ggactcgtcc tgacctcggc cgtccacccc ggcctcgctg cctccctgta
     4921 aatattttta aatatgaaca aaggaaaaat atattttatg atttaaaaaa taaatataat
     4981 tgggattttt aagaagtgag aaatgtgagc ggtgaagggg tgggcagggc tgggaaaact
     5041 ttgtacagtg gagaaaatat ttataaactt aattttttaa aacataaaaa aaaaaaaaaa
     5101 a
//
LOCUS       NM_001106888            4494 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus BICRA like chromatin remodeling complex
            associated protein (Bicral), transcript variant 2, mRNA.
ACCESSION   NM_001106888 XM_001065444 XM_217342
VERSION     NM_001106888.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4494)
  AUTHORS   Alpsoy,A. and Dykhuizen,E.C.
  TITLE     Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its
            paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes
  JOURNAL   J Biol Chem 293 (11), 3892-3903 (2018)
   PUBMED   29374058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217342.4, XM_001065444.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..4494
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="BICRA like chromatin remodeling complex associated
                     protein"
                     /db_xref="GeneID:301235"
                     /db_xref="RGD:1305680"
     exon            1..60
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="upstream in-frame stop codon"
     exon            61..106
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3302
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="GLTSCR1-like; BRD4 interacting chromatin remodeling
                     complex associated protein like; BRD4 interacting
                     chromatin remodelling complex associated protein like"
                     /codon_start=1
                     /product="BRD4-interacting chromatin-remodeling
                     complex-associated protein-like"
                     /protein_id="NP_001100358.1"
                     /db_xref="GeneID:301235"
                     /db_xref="RGD:1305680"
                     /translation="MDDDDDSCLLDLIGDPQALNYFLHGPSSKSSGDDVTNAGYSAAN
                     SNSIFANSTNADPKSSLKGVSNQLGEGPSDGLPLASSLQFLEDELESSPLPDLSEDQP
                     FDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSG
                     QTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLPNSSQISGSGQIQLIGS
                     FGNQPSMMTINNLDGSQIILKGSGQQAPSSVSGGLLVHRQTPNGNSLFGNPTSSPGAQ
                     PVTVPFNSTNFQASLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQSTYNVNSLGLQ
                     QHHVQQGISFASASSPQGSVVGPHMSVNIVNQQNARKPVTSQAVSSAGGSIVIHSPMG
                     QPHTPQSQFLIPTSLSVSSNSVHHVQTINGQLVQTQPSQLISGQVASEHVMLNRNSSN
                     MLRTNQPYAGQMLNNQSAAVQLVSGQTFATSGSPVIVNHASPQIVGGQMPLQQASPTV
                     LHLSPGQSSVSQGRPGFATMASVSSMSGPARFPAVSSASTAHPTLGPAVQSGASGSNF
                     TGDQLTQANRTPVPVSVSHRLPVSASKSPSTLSSTPGTQQQFFCQAPKKCLNQTAPIP
                     TPIPTSKTTDSLRQPQIPGLLSTALPGQDCGSKIMPAPLGTTQPQQENSVGSSPSQTA
                     VQVDSHSGQKRPAAKQLTKGAFILQQLQRDQAHAVTPDKSQFRSLTDTVQRLLSYHVC
                     QGSMPTEEDLSKVDSEFEEVATQLLKRTHAMLNKYRSLLLEDAMRINPSAEMVMIDRM
                     FNQEERASLSRDKRLALVDPEGFQADFCCSFKLDEAAPETPLDRSDQHRSKTSSLHQV
                     PRAQSRDRAKPGVAEATNHDQFHLVPNHIVVSAEGNISKKSEGHSRTLKFDKGVLGQY
                     RGPPEDKGGRRDPAKASGCSPGPEGHRKTLPRPDHGSESKLPGILASSHMEMPCLDSF
                     QDKALRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLEKTFKNILELKNAGRPQNDPAAS
                     GAVDLDFPSFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC"
     misc_feature    1557..>2075
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    1557..>2075
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    2199..2501
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Conserved region of unknown function on GLTSCR
                     protein; Region: GLTSCR1; pfam15249"
                     /db_xref="CDD:464589"
     misc_feature    2199..2501
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Conserved region of unknown function on GLTSCR
                     protein; Region: GLTSCR1; pfam15249"
                     /db_xref="CDD:464589"
     exon            107..155
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            156..224
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            225..1898
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2016
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2117
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2176
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2322
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2417
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2520
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..4494
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttattccacg catggcttga aatgggtgag aagcagggtt gccaggtgtc gatcactagt
       61 ttgtcatgga tgatgacgat gactcctgtc tcctcgatct tattggagac ccacaagcat
      121 tgaactattt tctgcacgga cctagcagta aatcgagcgg cgatgacgtg acgaacgcag
      181 ggtattctgc agccaattct aattcaattt tcgccaactc cacgaacgct gaccctaagt
      241 catccctcaa aggtgtaagt aaccagctcg gagaagggcc cagtgacggg ctgccgcttg
      301 caagcagcct tcagtttctt gaagatgaac ttgagtcttc tcctctccct gatctcagtg
      361 aggaccaacc ctttgacatt cttcagaaat ccttgcagga ggctaatatc actgaacaga
      421 cgctggcaga agaggcatat ctggatgcca gtataggctc gagccaacag tttgcacaag
      481 cccagcttca tccttcttca tcagcatcct ttactcaggc ttctaatgtt tctaattact
      541 caggtcagac actgcagcct atcggggtga ctcacgtgcc tgtcggagca tcgtttgcaa
      601 gcaatacagt gggtgtacag catggcttta tgcaacacgt ggggatcagt gttcccagcc
      661 agcatttgcc caatagcagc cagatcagtg gctccggtca gattcagtta atcgggtcct
      721 ttggtaatca gccttccatg atgactatta ataacctaga tggctctcaa atcatattga
      781 aaggcagtgg gcagcaagcc ccgtccagtg tgagtggggg gcttctggtt cacagacaga
      841 ctcctaacgg caactctttg tttgggaacc ccacttccag ccccggagca cagcctgtca
      901 ccgtcccatt taacagcaca aattttcaag catctctacc tgtgcataac atcattattc
      961 aaaggggtct cgcaccaaat tcaaataaag tcccaattaa tatccagcca aagccgatcc
     1021 agatgggtca gcagagtaca tacaatgtga acagccttgg actccagcag caccacgtcc
     1081 agcaagggat ctccttcgcc tctgcaagct cgccccaggg ctccgtggtt ggtccacaca
     1141 tgtctgtgaa cattgtcaac caacagaacg cgaggaagcc tgtcacctca caggcggtga
     1201 gcagcgcagg gggcagcatt gttattcact cccccatggg ccagcctcac acaccccaaa
     1261 gtcagttcct tatacccaca agcctttctg tcagctccaa ctcggtccac catgtccaga
     1321 ctataaatgg gcaacttgtt cagactcagc cctcccagct catctctggc caagtggcct
     1381 cagagcatgt catgttgaat aggaattctt ctaacatgct caggaccaac caaccatatg
     1441 ccggacagat gctcaacaac cagagtgccg ctgtccagct ggtgtctggg cagacttttg
     1501 ccacctctgg aagcccagtg atcgtcaacc atgcctctcc tcagatcgtg ggaggacaga
     1561 tgcccttgca gcaggcctca ccaactgtgc tacacctgtc gcctgggcag agcagtgttt
     1621 cccaaggaag gccaggcttc gccaccatgg cctcggtgag cagcatgtca ggacctgctc
     1681 ggttccccgc cgtcagctca gctagtactg cccaccctac tcttgggcct gcagtacagt
     1741 ctggggcatc aggatcaaac tttacgggag accagctgac acaggcaaac agaactccgg
     1801 tacccgtcag tgtgtcccac cgtcttccag tctctgcttc caaatctccc agcaccttga
     1861 gcagcacccc ggggactcag cagcagttct tctgtcaggc tccgaagaag tgtttgaacc
     1921 agaccgcccc cattcccacc cccattccca cgtccaagac cacagacagc ctgcggcaac
     1981 cacagatccc tgggctcttg agcacagcac tgccaggaca ggattgtgga agcaaaatta
     2041 tgccagcacc cttggggacc acacagccac agcaggaaaa ctcagttgga tcttccccga
     2101 gccagacagc cgtgcaggtg gacagtcatt caggacagaa gaggcctgct gccaaacagc
     2161 tgactaaagg agctttcatc ctccagcagt tacagaggga ccaagcccat gctgtgacac
     2221 ccgacaaaag ccagttccga tcactgactg acaccgtgca gagactgctc tcctaccacg
     2281 tgtgccaagg ctccatgccc acggaggaag acctgagcaa agtggacagt gaatttgaag
     2341 aagtcgccac tcagctcctc aaaaggaccc acgctatgct gaacaaatac agatccctgc
     2401 tcctcgaaga cgccatgagg atcaacccct ctgcagagat ggtgatgatt gataggatgt
     2461 tcaaccagga ggaaagagct tccctgtcac gggacaagcg tctggcgctc gtagatcctg
     2521 agggttttca ggccgatttc tgttgttcct ttaaacttga cgaagctgca cctgagacac
     2581 cgcttgacag gagtgaccag catcgcagca aaaccagctc gctccatcag gtgcccaggg
     2641 cccaaagcag agaccgagcc aagccaggcg tggcagaagc aacgaatcat gaccagtttc
     2701 atctagtgcc taaccacata gtggtctctg cagagggaaa catttctaaa aagtcagaag
     2761 gccacagtag aacactgaaa tttgacaaag gggtcttagg ccaataccgg ggtccgcctg
     2821 aggacaaggg cggccggagg gaccctgcca aggccagcgg gtgctctcca ggccctgaag
     2881 gccaccgcaa aactttgccc aggccagacc atggctctga gagcaagctc ccgggtatcc
     2941 tggccagctc gcacatggag atgccgtgcc tcgactcctt ccaggacaaa gccctgagga
     3001 attccccaaa gaatgaggtt ttacacacag acatcatgaa agggtcgggt gaaccccagc
     3061 cagatctcca gctcaccaag agcctagaga aaacctttaa gaacatcctg gaactcaaga
     3121 atgcggggcg gccgcagaac gacccagcgg ccagcggcgc ggtggacctg gacttcccca
     3181 gcttttctcc aatggcttcg caggaaaact gcctggaaaa gttcatcccg gaccacagcg
     3241 aaggcgttgt agaaacggac tccattttag aagcagctgt aaatagtatc ctagagtgtt
     3301 aatagcagcc gtcctccccc agaccctgcc ctggaccagt tacattctct cccagcaaag
     3361 caaatggaaa cgtctcctgt ccccagcctg cttggtcctc cgtcacaggt tatctttcta
     3421 atctccaccc tgttcttttg aagagcaata catgtcttcg tggctgcaga gagaccctca
     3481 gtaaaccccc ctctctagaa agcagtccga taggccctcc acatttcaag tgtcatggaa
     3541 gttttatggc cattgttggt taatttgttt tgtggtttgt ttcttagcac tgtcactcga
     3601 gaccacagta cacttggccc tgggtaacat tttgacaatc ataagtcatt tcaaaagaac
     3661 agacttatta aagaaaaatc aaacaggact gatagaagcc acttttttaa agactctctc
     3721 actgcagctc caaagtagtg gtttgctttt gttctgtttt gggggagagg gtatttgcgt
     3781 agggaagacc ccatgactct cctccatgct cggccctctg agcagtgaca gccagtgctc
     3841 tgcctggaac cccacaggcc tggccttaga cgccagtagc acagcgcaga gcaccctcag
     3901 actgccagtg ctgtgtgacg ctgctgaagc aaagcctttt gggtttgttg tttttttttt
     3961 ttttttaagc atatttatgt tgaattctgt ctgccaatgt tctgttctta accccaggtg
     4021 tacgccttga aattctcacg agctcagtag ggaacaatgg gagccagttc taaggcagca
     4081 agctggggag gctgctggag cccccagggt cttggtgcgt gcagcttaaa gagttttgcg
     4141 ttttataacc gggtaaaggc aacgtaacct atgttcttta gtgttgctga ctccgttcca
     4201 tttagcctct gtgtctcctc tccctcagcc cacagccaag gatcaaaagg ctttcaactt
     4261 gaaaatcacg ctgtgctctc tcagttgacg cttttgaagg gttcgctggc ctcgtttgtg
     4321 agaatagtag tcagcagtgt gtcatttatt cccaaacaca gtaaaccaaa ggtcacaacc
     4381 agcaggccac taaaggaagg aactgaggca ggagacgggc atgtcctggc cccgcctcgc
     4441 cgtgggtgct cctcgctcac ccgtggagcc ttcctctttt ttatttatgt tctt
//
LOCUS       NM_001434149            4159 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 7, mRNA.
ACCESSION   NM_001434149 XM_008764694
VERSION     NM_001434149.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4159)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4159)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4159)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4159)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4159)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4159)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4159)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_008764694.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.822523.1,
                                           SRR26360190.2871652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1613           JAXUCZ010000006.1  94520678-94520823   c
            1614-1752           JAXUCZ010000006.1  94516450-94516588   c
            1753-2056           JAXUCZ010000006.1  94499199-94499502   c
            2057-2219           JAXUCZ010000006.1  94496539-94496701   c
            2220-4159           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4159
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2282
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 7 is encoded by transcript variant 7;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 7"
                     /protein_id="NP_001421078.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKVPATPILQLEECCTH
                     NNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNAR
                     VKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLG
                     KTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFM
                     HNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLN
                     RNVQVTLHTGLPVPDFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1506..1745
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1506..1745
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1710..1715,1719..1724)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1710..1715,1719..1724)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1734..2249
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    1734..2249
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1613
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1752
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..2056
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2219
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..4159
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagtcc cagcaacccc catcctccag ctggaggagt
     1501 gttgcaccca caacaacagt gctacgctgt cctggaaaca gccccctctg tccactgtgg
     1561 ccgccgatgg ctacattctg gagctggatg atggcagtgg tggtcagttc cgggaagtgt
     1621 atgttggaaa agaaacaatg tgcacagtgg acggccttca cttcaacagc acatacaacg
     1681 cccgcgttaa ggccttcaac aaaacaggag tcagccccta cagcaagaca ctggtcctcc
     1741 agacgtctga ggtggcgtgg tttgcgtttg accccggctc ggcacactct gacatcatct
     1801 tctccaatga caacctgaca gtgacatgca gtagctacga tgaccgggtg gtgctgggga
     1861 aaactggctt ctccaagggc gtccactact gggagctgac catagatcgc tatgacaacc
     1921 accctgatcc agcatttggc gtggctcgca tcgatgtgat gaaggatatg atgttaggaa
     1981 aggacgacaa ggcttgggca atgtatgtgg acaataaccg gagctggttc atgcacaaca
     2041 actcgcacac caacagaact gaaggaggga tcacaaaagg ggccactatc ggggtcctcc
     2101 tcgacttaaa cagaaagaca ttaacgtttt tcgtcaacaa tgaacagcaa ggccccatag
     2161 cctttgagaa tgtggagggc ctgttctttc ctgccgtcag cctgaacagg aatgtacagg
     2221 tcacgcttca cactgggctt ccggtccccg acttctactc cagcagagct tccatagcct
     2281 aagggtgagc tgtggaggca ctggctgtcc ctgagaagga cagcccagag cctgcagcct
     2341 cagcagagga cacagagccg gtagaagaat gagaacagct ggtcctcagc aatctccacc
     2401 tttagagctc caccctttcc catcagcctc tccgcatcgc tgaacccagg ctcccttcct
     2461 cacccagaaa ctctacccgc gcagaggagc tctgcagccc accgctcccg tgtgttccca
     2521 cttccgtgtg ttctttttct ttaatttagt gggtttttgt tgttgtttgc ttgtttgttt
     2581 gtttttgttt taatgtaggt tgaattcatt ttgattcttt tctgattgtg ttttggtgac
     2641 ttacgtacac tacctggcac tgtcaaaaga cattctcctg gaaacttttt ttcttaagcg
     2701 tttggacaaa caaaggtgtt ctaggagagc aggtaggaaa gaagccgaat ttagagtttg
     2761 ccatttgact cctagaatgt tcttgccctg gttcttgtca agcaatgtta gttcttcatg
     2821 gctacttctt gggaggtggg cagaagtgca tttggcatcc agaagtctta ctacacccta
     2881 aagcacaaat acatcatcta cactggctca tggcagggta aggaccttcc agacaggctc
     2941 taggtactgg gaagaccagg tggcccaatg gtttgattca tttgactaat acaagttttt
     3001 aattaagaac tactacggac caggcactgt tcaagacact agaatgctgt gttcatgaac
     3061 agtctgtctt cctggaactt atattctatg taacaaagca acaaataacg tcaagttgtt
     3121 ctaagtacca gaaaggagag gagtcaaagg aggtgtcact gacaaaccct cagactgacg
     3181 ctgaacccac acactccagc catcacacag acatgtacca acccagtgct tttcccaccg
     3241 cactaccgta actaaggtct ctgctgccac tcaccgcaga gcccgtcttc ggcagaaatg
     3301 atgtcaccat tgttactcat tagtgctgtg ctcagaacaa gccttaaaag ccagaatgtt
     3361 aaaaaacaac atgaccagag gacacaggac ccagccacaa ccctgggcct cccgagttgc
     3421 aaaccacaac atttacatcc tcaggataaa catgacatct ccatgtatac tctctgtgcc
     3481 tgttgcaaat gagactccat ccgctcaccg ctgtcacagc ctgactttct aaagaagctc
     3541 aaatcgggtt tggaacagcg taagtgtgga catcattcct agcattgaca gaagactaac
     3601 caggcttacg actcttaacg gagtagatac ccttcagatg cttctgtttg acacgaagct
     3661 ttagagaatg taggacctgg gggcggggac ttctgattag ttgtgtaaat actttccact
     3721 gagccaagaa acccatcagt ataacagtga ccgacagagg tggggcggga cagccacagt
     3781 gctttggcaa agagtaatct atgtaaatag ctcatcctct gcccatgtgc tccctctaga
     3841 tcatctctgt ctttgtgttt ttctagttag aacctaattt actgaatggg tgctatcctg
     3901 tctatgtctg tctcgggttc ctgtgactac agaacactct cgtgggacta tactcgtttg
     3961 atctttgatt gttccgatga gactccatgg ctgggccgct agttactccc ttgattaaat
     4021 ccatccccct ggttagagtt ctagtgactt atatcaaata gtttacactg aactacaact
     4081 atagatgcat ataactgctg tactaggaga gaaaggtcat cctcggtatg ccaataaagc
     4141 atttttatga gaggaaaaa
//
LOCUS       NM_001434144            4459 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 2, mRNA.
ACCESSION   NM_001434144 XM_008764691
VERSION     NM_001434144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_008764691.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.35815.1,
                                           SRR26360194.1716999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-1797           JAXUCZ010000006.1  94515605-94515637   c
            1798-1986           JAXUCZ010000006.1  94503257-94503445   c
            1987-2028           JAXUCZ010000006.1  94500702-94500743   c
            2029-2052           JAXUCZ010000006.1  94500279-94500302   c
            2053-2356           JAXUCZ010000006.1  94499199-94499502   c
            2357-2519           JAXUCZ010000006.1  94496539-94496701   c
            2520-4459           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4459
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2582
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 2"
                     /protein_id="NP_001421073.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLR
                     RMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVD
                     IKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTID
                     RYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKG
                     ATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDF
                     YSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2052..2549
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2052..2549
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1797
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1986
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2028
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2052
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2356
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2519
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..4459
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggcagcgg gagcccatga gacaaaacct atgaaggaca
     1801 cagattcaga agaacagacc ctcccttttc cagtgccttc ggaaagattg ccgctccgta
     1861 gaatgagtcc tttctcctcc acccttaatc tacaacccag cttccccggg agatcctact
     1921 ttgatttccg gtcctcaccc caccagctga gcttgcattc ttctttacag tctctcaatg
     1981 caccgggctg caattttgag acacaatctg catcttactc tcaattagtt gacattaaaa
     2041 agctgttggc agtggcgtgg tttgcgtttg accccggctc ggcacactct gacatcatct
     2101 tctccaatga caacctgaca gtgacatgca gtagctacga tgaccgggtg gtgctgggga
     2161 aaactggctt ctccaagggc gtccactact gggagctgac catagatcgc tatgacaacc
     2221 accctgatcc agcatttggc gtggctcgca tcgatgtgat gaaggatatg atgttaggaa
     2281 aggacgacaa ggcttgggca atgtatgtgg acaataaccg gagctggttc atgcacaaca
     2341 actcgcacac caacagaact gaaggaggga tcacaaaagg ggccactatc ggggtcctcc
     2401 tcgacttaaa cagaaagaca ttaacgtttt tcgtcaacaa tgaacagcaa ggccccatag
     2461 cctttgagaa tgtggagggc ctgttctttc ctgccgtcag cctgaacagg aatgtacagg
     2521 tcacgcttca cactgggctt ccggtccccg acttctactc cagcagagct tccatagcct
     2581 aagggtgagc tgtggaggca ctggctgtcc ctgagaagga cagcccagag cctgcagcct
     2641 cagcagagga cacagagccg gtagaagaat gagaacagct ggtcctcagc aatctccacc
     2701 tttagagctc caccctttcc catcagcctc tccgcatcgc tgaacccagg ctcccttcct
     2761 cacccagaaa ctctacccgc gcagaggagc tctgcagccc accgctcccg tgtgttccca
     2821 cttccgtgtg ttctttttct ttaatttagt gggtttttgt tgttgtttgc ttgtttgttt
     2881 gtttttgttt taatgtaggt tgaattcatt ttgattcttt tctgattgtg ttttggtgac
     2941 ttacgtacac tacctggcac tgtcaaaaga cattctcctg gaaacttttt ttcttaagcg
     3001 tttggacaaa caaaggtgtt ctaggagagc aggtaggaaa gaagccgaat ttagagtttg
     3061 ccatttgact cctagaatgt tcttgccctg gttcttgtca agcaatgtta gttcttcatg
     3121 gctacttctt gggaggtggg cagaagtgca tttggcatcc agaagtctta ctacacccta
     3181 aagcacaaat acatcatcta cactggctca tggcagggta aggaccttcc agacaggctc
     3241 taggtactgg gaagaccagg tggcccaatg gtttgattca tttgactaat acaagttttt
     3301 aattaagaac tactacggac caggcactgt tcaagacact agaatgctgt gttcatgaac
     3361 agtctgtctt cctggaactt atattctatg taacaaagca acaaataacg tcaagttgtt
     3421 ctaagtacca gaaaggagag gagtcaaagg aggtgtcact gacaaaccct cagactgacg
     3481 ctgaacccac acactccagc catcacacag acatgtacca acccagtgct tttcccaccg
     3541 cactaccgta actaaggtct ctgctgccac tcaccgcaga gcccgtcttc ggcagaaatg
     3601 atgtcaccat tgttactcat tagtgctgtg ctcagaacaa gccttaaaag ccagaatgtt
     3661 aaaaaacaac atgaccagag gacacaggac ccagccacaa ccctgggcct cccgagttgc
     3721 aaaccacaac atttacatcc tcaggataaa catgacatct ccatgtatac tctctgtgcc
     3781 tgttgcaaat gagactccat ccgctcaccg ctgtcacagc ctgactttct aaagaagctc
     3841 aaatcgggtt tggaacagcg taagtgtgga catcattcct agcattgaca gaagactaac
     3901 caggcttacg actcttaacg gagtagatac ccttcagatg cttctgtttg acacgaagct
     3961 ttagagaatg taggacctgg gggcggggac ttctgattag ttgtgtaaat actttccact
     4021 gagccaagaa acccatcagt ataacagtga ccgacagagg tggggcggga cagccacagt
     4081 gctttggcaa agagtaatct atgtaaatag ctcatcctct gcccatgtgc tccctctaga
     4141 tcatctctgt ctttgtgttt ttctagttag aacctaattt actgaatggg tgctatcctg
     4201 tctatgtctg tctcgggttc ctgtgactac agaacactct cgtgggacta tactcgtttg
     4261 atctttgatt gttccgatga gactccatgg ctgggccgct agttactccc ttgattaaat
     4321 ccatccccct ggttagagtt ctagtgactt atatcaaata gtttacactg aactacaact
     4381 atagatgcat ataactgctg tactaggaga gaaaggtcat cctcggtatg ccaataaagc
     4441 atttttatga gaggaaaaa
//
LOCUS       NM_001434147            4405 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 5, mRNA.
ACCESSION   NM_001434147 XM_008764692
VERSION     NM_001434147.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4405)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4405)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4405)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4405)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_008764692.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.35817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-1797           JAXUCZ010000006.1  94515605-94515637   c
            1798-1986           JAXUCZ010000006.1  94503257-94503445   c
            1987-2028           JAXUCZ010000006.1  94500702-94500743   c
            2029-2052           JAXUCZ010000006.1  94500279-94500302   c
            2053-2302           JAXUCZ010000006.1  94499253-94499502   c
            2303-2465           JAXUCZ010000006.1  94496539-94496701   c
            2466-4405           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4405
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2528
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 5;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 5"
                     /protein_id="NP_001421076.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLR
                     RMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVD
                     IKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTID
                     RYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFV
                     NNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2052..2495
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2052..2495
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1797
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1986
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2028
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2052
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2302
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2465
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..4405
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggcagcgg gagcccatga gacaaaacct atgaaggaca
     1801 cagattcaga agaacagacc ctcccttttc cagtgccttc ggaaagattg ccgctccgta
     1861 gaatgagtcc tttctcctcc acccttaatc tacaacccag cttccccggg agatcctact
     1921 ttgatttccg gtcctcaccc caccagctga gcttgcattc ttctttacag tctctcaatg
     1981 caccgggctg caattttgag acacaatctg catcttactc tcaattagtt gacattaaaa
     2041 agctgttggc agtggcgtgg tttgcgtttg accccggctc ggcacactct gacatcatct
     2101 tctccaatga caacctgaca gtgacatgca gtagctacga tgaccgggtg gtgctgggga
     2161 aaactggctt ctccaagggc gtccactact gggagctgac catagatcgc tatgacaacc
     2221 accctgatcc agcatttggc gtggctcgca tcgatgtgat gaaggatatg atgttaggaa
     2281 aggacgacaa ggcttgggca ataactgaag gagggatcac aaaaggggcc actatcgggg
     2341 tcctcctcga cttaaacaga aagacattaa cgtttttcgt caacaatgaa cagcaaggcc
     2401 ccatagcctt tgagaatgtg gagggcctgt tctttcctgc cgtcagcctg aacaggaatg
     2461 tacaggtcac gcttcacact gggcttccgg tccccgactt ctactccagc agagcttcca
     2521 tagcctaagg gtgagctgtg gaggcactgg ctgtccctga gaaggacagc ccagagcctg
     2581 cagcctcagc agaggacaca gagccggtag aagaatgaga acagctggtc ctcagcaatc
     2641 tccaccttta gagctccacc ctttcccatc agcctctccg catcgctgaa cccaggctcc
     2701 cttcctcacc cagaaactct acccgcgcag aggagctctg cagcccaccg ctcccgtgtg
     2761 ttcccacttc cgtgtgttct ttttctttaa tttagtgggt ttttgttgtt gtttgcttgt
     2821 ttgtttgttt ttgttttaat gtaggttgaa ttcattttga ttcttttctg attgtgtttt
     2881 ggtgacttac gtacactacc tggcactgtc aaaagacatt ctcctggaaa ctttttttct
     2941 taagcgtttg gacaaacaaa ggtgttctag gagagcaggt aggaaagaag ccgaatttag
     3001 agtttgccat ttgactccta gaatgttctt gccctggttc ttgtcaagca atgttagttc
     3061 ttcatggcta cttcttggga ggtgggcaga agtgcatttg gcatccagaa gtcttactac
     3121 accctaaagc acaaatacat catctacact ggctcatggc agggtaagga ccttccagac
     3181 aggctctagg tactgggaag accaggtggc ccaatggttt gattcatttg actaatacaa
     3241 gtttttaatt aagaactact acggaccagg cactgttcaa gacactagaa tgctgtgttc
     3301 atgaacagtc tgtcttcctg gaacttatat tctatgtaac aaagcaacaa ataacgtcaa
     3361 gttgttctaa gtaccagaaa ggagaggagt caaaggaggt gtcactgaca aaccctcaga
     3421 ctgacgctga acccacacac tccagccatc acacagacat gtaccaaccc agtgcttttc
     3481 ccaccgcact accgtaacta aggtctctgc tgccactcac cgcagagccc gtcttcggca
     3541 gaaatgatgt caccattgtt actcattagt gctgtgctca gaacaagcct taaaagccag
     3601 aatgttaaaa aacaacatga ccagaggaca caggacccag ccacaaccct gggcctcccg
     3661 agttgcaaac cacaacattt acatcctcag gataaacatg acatctccat gtatactctc
     3721 tgtgcctgtt gcaaatgaga ctccatccgc tcaccgctgt cacagcctga ctttctaaag
     3781 aagctcaaat cgggtttgga acagcgtaag tgtggacatc attcctagca ttgacagaag
     3841 actaaccagg cttacgactc ttaacggagt agataccctt cagatgcttc tgtttgacac
     3901 gaagctttag agaatgtagg acctgggggc ggggacttct gattagttgt gtaaatactt
     3961 tccactgagc caagaaaccc atcagtataa cagtgaccga cagaggtggg gcgggacagc
     4021 cacagtgctt tggcaaagag taatctatgt aaatagctca tcctctgccc atgtgctccc
     4081 tctagatcat ctctgtcttt gtgtttttct agttagaacc taatttactg aatgggtgct
     4141 atcctgtcta tgtctgtctc gggttcctgt gactacagaa cactctcgtg ggactatact
     4201 cgtttgatct ttgattgttc cgatgagact ccatggctgg gccgctagtt actcccttga
     4261 ttaaatccat ccccctggtt agagttctag tgacttatat caaatagttt acactgaact
     4321 acaactatag atgcatataa ctgctgtact aggagagaaa ggtcatcctc ggtatgccaa
     4381 taaagcattt ttatgagagg aaaaa
//
LOCUS       NM_001434148            4402 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 6, mRNA.
ACCESSION   NM_001434148 XM_008764693
VERSION     NM_001434148.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4402)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4402)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4402)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4402)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4402)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4402)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4402)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_008764693.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.908550.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-1794           JAXUCZ010000006.1  94515605-94515634   c
            1795-1983           JAXUCZ010000006.1  94503257-94503445   c
            1984-2025           JAXUCZ010000006.1  94500702-94500743   c
            2026-2049           JAXUCZ010000006.1  94500279-94500302   c
            2050-2299           JAXUCZ010000006.1  94499253-94499502   c
            2300-2462           JAXUCZ010000006.1  94496539-94496701   c
            2463-4402           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4402
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2525
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 6 is encoded by transcript variant 6;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 6"
                     /protein_id="NP_001421077.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEAGAHETKPMKDTDSEEQTLPFPVPSERLPLRR
                     MSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDI
                     KKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDR
                     YDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFVN
                     NEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2049..2492
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2049..2492
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1794
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2025
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2049
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2299
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2462
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..4402
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggcgggag cccatgagac aaaacctatg aaggacacag
     1801 attcagaaga acagaccctc ccttttccag tgccttcgga aagattgccg ctccgtagaa
     1861 tgagtccttt ctcctccacc cttaatctac aacccagctt ccccgggaga tcctactttg
     1921 atttccggtc ctcaccccac cagctgagct tgcattcttc tttacagtct ctcaatgcac
     1981 cgggctgcaa ttttgagaca caatctgcat cttactctca attagttgac attaaaaagc
     2041 tgttggcagt ggcgtggttt gcgtttgacc ccggctcggc acactctgac atcatcttct
     2101 ccaatgacaa cctgacagtg acatgcagta gctacgatga ccgggtggtg ctggggaaaa
     2161 ctggcttctc caagggcgtc cactactggg agctgaccat agatcgctat gacaaccacc
     2221 ctgatccagc atttggcgtg gctcgcatcg atgtgatgaa ggatatgatg ttaggaaagg
     2281 acgacaaggc ttgggcaata actgaaggag ggatcacaaa aggggccact atcggggtcc
     2341 tcctcgactt aaacagaaag acattaacgt ttttcgtcaa caatgaacag caaggcccca
     2401 tagcctttga gaatgtggag ggcctgttct ttcctgccgt cagcctgaac aggaatgtac
     2461 aggtcacgct tcacactggg cttccggtcc ccgacttcta ctccagcaga gcttccatag
     2521 cctaagggtg agctgtggag gcactggctg tccctgagaa ggacagccca gagcctgcag
     2581 cctcagcaga ggacacagag ccggtagaag aatgagaaca gctggtcctc agcaatctcc
     2641 acctttagag ctccaccctt tcccatcagc ctctccgcat cgctgaaccc aggctccctt
     2701 cctcacccag aaactctacc cgcgcagagg agctctgcag cccaccgctc ccgtgtgttc
     2761 ccacttccgt gtgttctttt tctttaattt agtgggtttt tgttgttgtt tgcttgtttg
     2821 tttgtttttg ttttaatgta ggttgaattc attttgattc ttttctgatt gtgttttggt
     2881 gacttacgta cactacctgg cactgtcaaa agacattctc ctggaaactt tttttcttaa
     2941 gcgtttggac aaacaaaggt gttctaggag agcaggtagg aaagaagccg aatttagagt
     3001 ttgccatttg actcctagaa tgttcttgcc ctggttcttg tcaagcaatg ttagttcttc
     3061 atggctactt cttgggaggt gggcagaagt gcatttggca tccagaagtc ttactacacc
     3121 ctaaagcaca aatacatcat ctacactggc tcatggcagg gtaaggacct tccagacagg
     3181 ctctaggtac tgggaagacc aggtggccca atggtttgat tcatttgact aatacaagtt
     3241 tttaattaag aactactacg gaccaggcac tgttcaagac actagaatgc tgtgttcatg
     3301 aacagtctgt cttcctggaa cttatattct atgtaacaaa gcaacaaata acgtcaagtt
     3361 gttctaagta ccagaaagga gaggagtcaa aggaggtgtc actgacaaac cctcagactg
     3421 acgctgaacc cacacactcc agccatcaca cagacatgta ccaacccagt gcttttccca
     3481 ccgcactacc gtaactaagg tctctgctgc cactcaccgc agagcccgtc ttcggcagaa
     3541 atgatgtcac cattgttact cattagtgct gtgctcagaa caagccttaa aagccagaat
     3601 gttaaaaaac aacatgacca gaggacacag gacccagcca caaccctggg cctcccgagt
     3661 tgcaaaccac aacatttaca tcctcaggat aaacatgaca tctccatgta tactctctgt
     3721 gcctgttgca aatgagactc catccgctca ccgctgtcac agcctgactt tctaaagaag
     3781 ctcaaatcgg gtttggaaca gcgtaagtgt ggacatcatt cctagcattg acagaagact
     3841 aaccaggctt acgactctta acggagtaga tacccttcag atgcttctgt ttgacacgaa
     3901 gctttagaga atgtaggacc tgggggcggg gacttctgat tagttgtgta aatactttcc
     3961 actgagccaa gaaacccatc agtataacag tgaccgacag aggtggggcg ggacagccac
     4021 agtgctttgg caaagagtaa tctatgtaaa tagctcatcc tctgcccatg tgctccctct
     4081 agatcatctc tgtctttgtg tttttctagt tagaacctaa tttactgaat gggtgctatc
     4141 ctgtctatgt ctgtctcggg ttcctgtgac tacagaacac tctcgtggga ctatactcgt
     4201 ttgatctttg attgttccga tgagactcca tggctgggcc gctagttact cccttgatta
     4261 aatccatccc cctggttaga gttctagtga cttatatcaa atagtttaca ctgaactaca
     4321 actatagatg catataactg ctgtactagg agagaaaggt catcctcggt atgccaataa
     4381 agcattttta tgagaggaaa aa
//
LOCUS       NM_001434150            4117 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 8, mRNA.
ACCESSION   NM_001434150 XM_039111706
VERSION     NM_001434150.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4117)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4117)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4117)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4117)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4117)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4117)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4117)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_039111706.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1223218.1,
                                           SRR26360194.2377084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-2014           JAXUCZ010000006.1  94499253-94499502   c
            2015-2177           JAXUCZ010000006.1  94496539-94496701   c
            2178-4117           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4117
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2240
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 8 is encoded by transcript variant 8;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 8"
                     /protein_id="NP_001421079.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDR
                     VVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGIT
                     KGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVP
                     DFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1746..2207
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    1746..2207
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2014
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2177
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..4117
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggtggcgt ggtttgcgtt tgaccccggc tcggcacact
     1801 ctgacatcat cttctccaat gacaacctga cagtgacatg cagtagctac gatgaccggg
     1861 tggtgctggg gaaaactggc ttctccaagg gcgtccacta ctgggagctg accatagatc
     1921 gctatgacaa ccaccctgat ccagcatttg gcgtggctcg catcgatgtg atgaaggata
     1981 tgatgttagg aaaggacgac aaggcttggg caataactga aggagggatc acaaaagggg
     2041 ccactatcgg ggtcctcctc gacttaaaca gaaagacatt aacgtttttc gtcaacaatg
     2101 aacagcaagg ccccatagcc tttgagaatg tggagggcct gttctttcct gccgtcagcc
     2161 tgaacaggaa tgtacaggtc acgcttcaca ctgggcttcc ggtccccgac ttctactcca
     2221 gcagagcttc catagcctaa gggtgagctg tggaggcact ggctgtccct gagaaggaca
     2281 gcccagagcc tgcagcctca gcagaggaca cagagccggt agaagaatga gaacagctgg
     2341 tcctcagcaa tctccacctt tagagctcca ccctttccca tcagcctctc cgcatcgctg
     2401 aacccaggct cccttcctca cccagaaact ctacccgcgc agaggagctc tgcagcccac
     2461 cgctcccgtg tgttcccact tccgtgtgtt ctttttcttt aatttagtgg gtttttgttg
     2521 ttgtttgctt gtttgtttgt ttttgtttta atgtaggttg aattcatttt gattcttttc
     2581 tgattgtgtt ttggtgactt acgtacacta cctggcactg tcaaaagaca ttctcctgga
     2641 aacttttttt cttaagcgtt tggacaaaca aaggtgttct aggagagcag gtaggaaaga
     2701 agccgaattt agagtttgcc atttgactcc tagaatgttc ttgccctggt tcttgtcaag
     2761 caatgttagt tcttcatggc tacttcttgg gaggtgggca gaagtgcatt tggcatccag
     2821 aagtcttact acaccctaaa gcacaaatac atcatctaca ctggctcatg gcagggtaag
     2881 gaccttccag acaggctcta ggtactggga agaccaggtg gcccaatggt ttgattcatt
     2941 tgactaatac aagtttttaa ttaagaacta ctacggacca ggcactgttc aagacactag
     3001 aatgctgtgt tcatgaacag tctgtcttcc tggaacttat attctatgta acaaagcaac
     3061 aaataacgtc aagttgttct aagtaccaga aaggagagga gtcaaaggag gtgtcactga
     3121 caaaccctca gactgacgct gaacccacac actccagcca tcacacagac atgtaccaac
     3181 ccagtgcttt tcccaccgca ctaccgtaac taaggtctct gctgccactc accgcagagc
     3241 ccgtcttcgg cagaaatgat gtcaccattg ttactcatta gtgctgtgct cagaacaagc
     3301 cttaaaagcc agaatgttaa aaaacaacat gaccagagga cacaggaccc agccacaacc
     3361 ctgggcctcc cgagttgcaa accacaacat ttacatcctc aggataaaca tgacatctcc
     3421 atgtatactc tctgtgcctg ttgcaaatga gactccatcc gctcaccgct gtcacagcct
     3481 gactttctaa agaagctcaa atcgggtttg gaacagcgta agtgtggaca tcattcctag
     3541 cattgacaga agactaacca ggcttacgac tcttaacgga gtagataccc ttcagatgct
     3601 tctgtttgac acgaagcttt agagaatgta ggacctgggg gcggggactt ctgattagtt
     3661 gtgtaaatac tttccactga gccaagaaac ccatcagtat aacagtgacc gacagaggtg
     3721 gggcgggaca gccacagtgc tttggcaaag agtaatctat gtaaatagct catcctctgc
     3781 ccatgtgctc cctctagatc atctctgtct ttgtgttttt ctagttagaa cctaatttac
     3841 tgaatgggtg ctatcctgtc tatgtctgtc tcgggttcct gtgactacag aacactctcg
     3901 tgggactata ctcgtttgat ctttgattgt tccgatgaga ctccatggct gggccgctag
     3961 ttactccctt gattaaatcc atccccctgg ttagagttct agtgacttat atcaaatagt
     4021 ttacactgaa ctacaactat agatgcatat aactgctgta ctaggagaga aaggtcatcc
     4081 tcggtatgcc aataaagcat ttttatgaga ggaaaaa
//
LOCUS       NM_001434145            4456 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 3, mRNA.
ACCESSION   NM_001434145 XM_017593996
VERSION     NM_001434145.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_017593996.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1064931.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-1794           JAXUCZ010000006.1  94515605-94515634   c
            1795-1983           JAXUCZ010000006.1  94503257-94503445   c
            1984-2025           JAXUCZ010000006.1  94500702-94500743   c
            2026-2049           JAXUCZ010000006.1  94500279-94500302   c
            2050-2353           JAXUCZ010000006.1  94499199-94499502   c
            2354-2516           JAXUCZ010000006.1  94496539-94496701   c
            2517-4456           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4456
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2579
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 3"
                     /protein_id="NP_001421074.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEAGAHETKPMKDTDSEEQTLPFPVPSERLPLRR
                     MSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDI
                     KKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDR
                     YDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGA
                     TIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFY
                     SSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2049..2546
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2049..2546
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1794
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2025
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2049
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2353
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2516
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..4456
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggcgggag cccatgagac aaaacctatg aaggacacag
     1801 attcagaaga acagaccctc ccttttccag tgccttcgga aagattgccg ctccgtagaa
     1861 tgagtccttt ctcctccacc cttaatctac aacccagctt ccccgggaga tcctactttg
     1921 atttccggtc ctcaccccac cagctgagct tgcattcttc tttacagtct ctcaatgcac
     1981 cgggctgcaa ttttgagaca caatctgcat cttactctca attagttgac attaaaaagc
     2041 tgttggcagt ggcgtggttt gcgtttgacc ccggctcggc acactctgac atcatcttct
     2101 ccaatgacaa cctgacagtg acatgcagta gctacgatga ccgggtggtg ctggggaaaa
     2161 ctggcttctc caagggcgtc cactactggg agctgaccat agatcgctat gacaaccacc
     2221 ctgatccagc atttggcgtg gctcgcatcg atgtgatgaa ggatatgatg ttaggaaagg
     2281 acgacaaggc ttgggcaatg tatgtggaca ataaccggag ctggttcatg cacaacaact
     2341 cgcacaccaa cagaactgaa ggagggatca caaaaggggc cactatcggg gtcctcctcg
     2401 acttaaacag aaagacatta acgtttttcg tcaacaatga acagcaaggc cccatagcct
     2461 ttgagaatgt ggagggcctg ttctttcctg ccgtcagcct gaacaggaat gtacaggtca
     2521 cgcttcacac tgggcttccg gtccccgact tctactccag cagagcttcc atagcctaag
     2581 ggtgagctgt ggaggcactg gctgtccctg agaaggacag cccagagcct gcagcctcag
     2641 cagaggacac agagccggta gaagaatgag aacagctggt cctcagcaat ctccaccttt
     2701 agagctccac cctttcccat cagcctctcc gcatcgctga acccaggctc ccttcctcac
     2761 ccagaaactc tacccgcgca gaggagctct gcagcccacc gctcccgtgt gttcccactt
     2821 ccgtgtgttc tttttcttta atttagtggg tttttgttgt tgtttgcttg tttgtttgtt
     2881 tttgttttaa tgtaggttga attcattttg attcttttct gattgtgttt tggtgactta
     2941 cgtacactac ctggcactgt caaaagacat tctcctggaa actttttttc ttaagcgttt
     3001 ggacaaacaa aggtgttcta ggagagcagg taggaaagaa gccgaattta gagtttgcca
     3061 tttgactcct agaatgttct tgccctggtt cttgtcaagc aatgttagtt cttcatggct
     3121 acttcttggg aggtgggcag aagtgcattt ggcatccaga agtcttacta caccctaaag
     3181 cacaaataca tcatctacac tggctcatgg cagggtaagg accttccaga caggctctag
     3241 gtactgggaa gaccaggtgg cccaatggtt tgattcattt gactaataca agtttttaat
     3301 taagaactac tacggaccag gcactgttca agacactaga atgctgtgtt catgaacagt
     3361 ctgtcttcct ggaacttata ttctatgtaa caaagcaaca aataacgtca agttgttcta
     3421 agtaccagaa aggagaggag tcaaaggagg tgtcactgac aaaccctcag actgacgctg
     3481 aacccacaca ctccagccat cacacagaca tgtaccaacc cagtgctttt cccaccgcac
     3541 taccgtaact aaggtctctg ctgccactca ccgcagagcc cgtcttcggc agaaatgatg
     3601 tcaccattgt tactcattag tgctgtgctc agaacaagcc ttaaaagcca gaatgttaaa
     3661 aaacaacatg accagaggac acaggaccca gccacaaccc tgggcctccc gagttgcaaa
     3721 ccacaacatt tacatcctca ggataaacat gacatctcca tgtatactct ctgtgcctgt
     3781 tgcaaatgag actccatccg ctcaccgctg tcacagcctg actttctaaa gaagctcaaa
     3841 tcgggtttgg aacagcgtaa gtgtggacat cattcctagc attgacagaa gactaaccag
     3901 gcttacgact cttaacggag tagataccct tcagatgctt ctgtttgaca cgaagcttta
     3961 gagaatgtag gacctggggg cggggacttc tgattagttg tgtaaatact ttccactgag
     4021 ccaagaaacc catcagtata acagtgaccg acagaggtgg ggcgggacag ccacagtgct
     4081 ttggcaaaga gtaatctatg taaatagctc atcctctgcc catgtgctcc ctctagatca
     4141 tctctgtctt tgtgtttttc tagttagaac ctaatttact gaatgggtgc tatcctgtct
     4201 atgtctgtct cgggttcctg tgactacaga acactctcgt gggactatac tcgtttgatc
     4261 tttgattgtt ccgatgagac tccatggctg ggccgctagt tactcccttg attaaatcca
     4321 tccccctggt tagagttcta gtgacttata tcaaatagtt tacactgaac tacaactata
     4381 gatgcatata actgctgtac taggagagaa aggtcatcct cggtatgcca ataaagcatt
     4441 tttatgagag gaaaaa
//
LOCUS       NM_130420               4171 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 1, mRNA.
ACCESSION   NM_130420
VERSION     NM_130420.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4171)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4171)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4171)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4171)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4171)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4171)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced NM_130420.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF350422.1, SRR26360190.465027.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-2068           JAXUCZ010000006.1  94499199-94499502   c
            2069-2231           JAXUCZ010000006.1  94496539-94496701   c
            2232-4171           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4171
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2294
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 1"
                     /protein_id="NP_569104.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDR
                     VVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNR
                     SWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPA
                     VSLNRNVQVTLHTGLPVPDFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1746..2261
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    1746..2261
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2068
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2231
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..4171
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggtggcgt ggtttgcgtt tgaccccggc tcggcacact
     1801 ctgacatcat cttctccaat gacaacctga cagtgacatg cagtagctac gatgaccggg
     1861 tggtgctggg gaaaactggc ttctccaagg gcgtccacta ctgggagctg accatagatc
     1921 gctatgacaa ccaccctgat ccagcatttg gcgtggctcg catcgatgtg atgaaggata
     1981 tgatgttagg aaaggacgac aaggcttggg caatgtatgt ggacaataac cggagctggt
     2041 tcatgcacaa caactcgcac accaacagaa ctgaaggagg gatcacaaaa ggggccacta
     2101 tcggggtcct cctcgactta aacagaaaga cattaacgtt tttcgtcaac aatgaacagc
     2161 aaggccccat agcctttgag aatgtggagg gcctgttctt tcctgccgtc agcctgaaca
     2221 ggaatgtaca ggtcacgctt cacactgggc ttccggtccc cgacttctac tccagcagag
     2281 cttccatagc ctaagggtga gctgtggagg cactggctgt ccctgagaag gacagcccag
     2341 agcctgcagc ctcagcagag gacacagagc cggtagaaga atgagaacag ctggtcctca
     2401 gcaatctcca cctttagagc tccacccttt cccatcagcc tctccgcatc gctgaaccca
     2461 ggctcccttc ctcacccaga aactctaccc gcgcagagga gctctgcagc ccaccgctcc
     2521 cgtgtgttcc cacttccgtg tgttcttttt ctttaattta gtgggttttt gttgttgttt
     2581 gcttgtttgt ttgtttttgt tttaatgtag gttgaattca ttttgattct tttctgattg
     2641 tgttttggtg acttacgtac actacctggc actgtcaaaa gacattctcc tggaaacttt
     2701 ttttcttaag cgtttggaca aacaaaggtg ttctaggaga gcaggtagga aagaagccga
     2761 atttagagtt tgccatttga ctcctagaat gttcttgccc tggttcttgt caagcaatgt
     2821 tagttcttca tggctacttc ttgggaggtg ggcagaagtg catttggcat ccagaagtct
     2881 tactacaccc taaagcacaa atacatcatc tacactggct catggcaggg taaggacctt
     2941 ccagacaggc tctaggtact gggaagacca ggtggcccaa tggtttgatt catttgacta
     3001 atacaagttt ttaattaaga actactacgg accaggcact gttcaagaca ctagaatgct
     3061 gtgttcatga acagtctgtc ttcctggaac ttatattcta tgtaacaaag caacaaataa
     3121 cgtcaagttg ttctaagtac cagaaaggag aggagtcaaa ggaggtgtca ctgacaaacc
     3181 ctcagactga cgctgaaccc acacactcca gccatcacac agacatgtac caacccagtg
     3241 cttttcccac cgcactaccg taactaaggt ctctgctgcc actcaccgca gagcccgtct
     3301 tcggcagaaa tgatgtcacc attgttactc attagtgctg tgctcagaac aagccttaaa
     3361 agccagaatg ttaaaaaaca acatgaccag aggacacagg acccagccac aaccctgggc
     3421 ctcccgagtt gcaaaccaca acatttacat cctcaggata aacatgacat ctccatgtat
     3481 actctctgtg cctgttgcaa atgagactcc atccgctcac cgctgtcaca gcctgacttt
     3541 ctaaagaagc tcaaatcggg tttggaacag cgtaagtgtg gacatcattc ctagcattga
     3601 cagaagacta accaggctta cgactcttaa cggagtagat acccttcaga tgcttctgtt
     3661 tgacacgaag ctttagagaa tgtaggacct gggggcgggg acttctgatt agttgtgtaa
     3721 atactttcca ctgagccaag aaacccatca gtataacagt gaccgacaga ggtggggcgg
     3781 gacagccaca gtgctttggc aaagagtaat ctatgtaaat agctcatcct ctgcccatgt
     3841 gctccctcta gatcatctct gtctttgtgt ttttctagtt agaacctaat ttactgaatg
     3901 ggtgctatcc tgtctatgtc tgtctcgggt tcctgtgact acagaacact ctcgtgggac
     3961 tatactcgtt tgatctttga ttgttccgat gagactccat ggctgggccg ctagttactc
     4021 ccttgattaa atccatcccc ctggttagag ttctagtgac ttatatcaaa tagtttacac
     4081 tgaactacaa ctatagatgc atataactgc tgtactagga gagaaaggtc atcctcggta
     4141 tgccaataaa gcatttttat gagaggaaaa a
//
LOCUS       NM_001434146            4426 bp    mRNA    linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript
            variant 4, mRNA.
ACCESSION   NM_001434146 XM_017593999
VERSION     NM_001434146.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4426)
  AUTHORS   Li,J. and Zeng,Q.
  TITLE     Trim9 regulates the directional differentiation of retinal Muller
            cells to retinal ganglion cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (10), 1561-1571 (2023)
   PUBMED   38432885
  REMARK    GeneRIF: Trim9 regulates the directional differentiation of retinal
            Muller cells to retinal ganglion cells.
REFERENCE   2  (bases 1 to 4426)
  AUTHORS   Zeng,Q., Zhou,J. and Hua,X.
  TITLE     TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (8), 586-595 (2023)
   PUBMED   37792226
  REMARK    GeneRIF: TRIM9 promotes Muller cell-derived retinal stem cells to
            differentiate into retinal ganglion cells by regulating Atoh7.
REFERENCE   3  (bases 1 to 4426)
  AUTHORS   Morikawa,R.K., Kanamori,T., Yasunaga,K. and Emoto,K.
  TITLE     Different levels of the Tripartite motif protein, Anomalies in
            sensory axon patterning (Asap), regulate distinct axonal
            projections of Drosophila sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19389-19394 (2011)
   PUBMED   22084112
REFERENCE   4  (bases 1 to 4426)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
REFERENCE   5  (bases 1 to 4426)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   6  (bases 1 to 4426)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (bases 1 to 4426)
  AUTHORS   Koroll,M., Rathjen,F.G. and Volkmer,H.
  TITLE     The neural cell recognition molecule neurofascin interacts with
            syntenin-1 but not with syntenin-2, both of which reveal
            self-associating activity
  JOURNAL   J Biol Chem 276 (14), 10646-10654 (2001)
   PUBMED   11152476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 22, 2024 this sequence version replaced XM_017593999.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1999247.1,
                                           SRR26360194.1756340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-983               JAXUCZ010000006.1  94591572-94592554   c
            984-1079            JAXUCZ010000006.1  94539942-94540037   c
            1080-1202           JAXUCZ010000006.1  94537925-94538047   c
            1203-1313           JAXUCZ010000006.1  94529252-94529362   c
            1314-1467           JAXUCZ010000006.1  94528022-94528175   c
            1468-1625           JAXUCZ010000006.1  94520678-94520835   c
            1626-1764           JAXUCZ010000006.1  94516450-94516588   c
            1765-1953           JAXUCZ010000006.1  94503257-94503445   c
            1954-1995           JAXUCZ010000006.1  94500702-94500743   c
            1996-2019           JAXUCZ010000006.1  94500279-94500302   c
            2020-2323           JAXUCZ010000006.1  94499199-94499502   c
            2324-2486           JAXUCZ010000006.1  94496539-94496701   c
            2487-4426           JAXUCZ010000006.1  94492789-94494728   c
FEATURES             Location/Qualifiers
     source          1..4426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4426
                     /gene="Trim9"
                     /note="tripartite motif-containing 9"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
     exon            1..983
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Trim9"
                     /note="upstream in-frame stop codon"
     CDS             162..2549
                     /gene="Trim9"
                     /EC_number="2.3.2.27"
                     /note="isoform 4 is encoded by transcript variant 4;
                     tripartite motif-containing protein 9; E3
                     ubiquitin-protein ligase TRIM9; SNAP-25-interacting RING
                     finger protein; tripartite motif protein 9; Spring;
                     RING-type E3 ubiquitin transferase TRIM9"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 4"
                     /protein_id="NP_001421075.1"
                     /db_xref="GeneID:155812"
                     /db_xref="RGD:621540"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNL
                     QPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFA
                     FDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFG
                     VARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNR
                     KTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    174..308
                     /gene="Trim9"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: RING-HC_TRIM9; cd16755"
                     /db_xref="CDD:438413"
     misc_feature    282..284
                     /gene="Trim9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    291..293
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    297..299
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    306..308
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    318..320
                     /gene="Trim9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C7M3; propagated from
                     UniProtKB/Swiss-Prot (Q91ZY8.1); phosphorylation site"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    657..797
                     /gene="Trim9"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox1_TRIM9_C-I; cd19843"
                     /db_xref="CDD:380901"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    828..974
                     /gene="Trim9"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     Region: Bbox2_TRIM9_C-I; cd19826"
                     /db_xref="CDD:380884"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    978..1358
                     /gene="Trim9"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    1518..1757
                     /gene="Trim9"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1722..1727,1731..1736)
                     /gene="Trim9"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2019..2516
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     misc_feature    2019..2516
                     /gene="Trim9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; Region: SPRY_PRY_TRIM67_9;
                     cd12889"
                     /db_xref="CDD:293947"
     exon            984..1079
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1202
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1467
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1625
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1764
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1953
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..1995
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2019
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2323
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2486
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..4426
                     /gene="Trim9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagcgc gtcctgggga gtcggcgcct aggcgacgcg gaaaggcgcc accaccgccg
       61 ccgctggcca aggtgctgga caccacaggc ctatcgactg cttcgccagg tcaggccccc
      121 tttgccgcag cctctgctgc ctcgcttcca gccaggtccc catggaagag atggaagaag
      181 agttaaaatg ccccgtgtgt ggctccttct atcgggagcc catcatcctg ccctgctctc
      241 acaatttatg ccaggcttgc gcccgcaaca tcctggtgca gaccccggag tccgagtccc
      301 cccagagccg ccgggcctcg ggctctgggg tttctgacta tgactatctg gacctggaca
      361 agatgagcct ttacagcgag gcggacagcg gctatggctc ctacggaggt ttcgccagcg
      421 cccccactac cccgtgccag aagtcgccca acggcgtccg tgttttcccc cctgctatgc
      481 cgccaccgcc cacccacctg tcaccggctt tggcccctgt gccccgcaac tcctgcatta
      541 cctgccccca gtgccaccgc agcctcattc tggatgaccg ggggctccgc ggcttcccca
      601 agaaccgcgt cctggaaggg gtcatcgacc gctaccaaca gagcaaagcc gcggccctca
      661 agtgccagct ctgtgagaag gcgcccaagg aagccacggt catgtgcgaa cagtgcgatg
      721 tcttctactg cgacccttgc cgtctacgct gccacccacc gaggggtccc ctagccaaac
      781 accgtctggt gcccccggcc cagggtcgcg taagccgacg gctgagcccg cgcaaggtct
      841 ccacctgcac agaccacgag ctggagaacc acagcatgta ctgtgtgcaa tgcaagatgc
      901 cggtgtgcta ccagtgcttg gaggagggca aacactccag ccacgaagtc aaggctttgg
      961 gggctatgtg gaaattgcac aagagccagc tttcccaggc gctgaatgga ttgtcagata
     1021 gagccaaaga agccaaggag ttcctggtgc aactccgcac catggtgcaa caaatccagg
     1081 aaaacagtgt ggagtttgaa gcctgcctgg tggctcagtg cgatgctctc attgatgccc
     1141 taaaccgaag gaaggctcag ctgctggccc gggtcaacaa ggaacatgag cacaagctga
     1201 aggtggtccg ggaccagatc tctcattgca cagtgaaact gcgccagacc acgggcctca
     1261 tggagtactg cttggaagtg attaaggaga acgaccccag tggcttcctg cagatttcag
     1321 atgccctcat cagacgagtt cacttaactg aggaccagtg gggaaaaggc acactcactc
     1381 ccaggatgac cacggacttc gacctgagcc tggacaacag tcctctgcta cagtccatcc
     1441 accagctgga cttcgtgcaa gtgaaagctt cctctccagt cccagcaacc cccatcctcc
     1501 agctggagga gtgttgcacc cacaacaaca gtgctacgct gtcctggaaa cagccccctc
     1561 tgtccactgt ggccgccgat ggctacattc tggagctgga tgatggcagt ggtggtcagt
     1621 tccgggaagt gtatgttgga aaagaaacaa tgtgcacagt ggacggcctt cacttcaaca
     1681 gcacatacaa cgcccgcgtt aaggccttca acaaaacagg agtcagcccc tacagcaaga
     1741 cactggtcct ccagacgtct gaggacacag attcagaaga acagaccctc ccttttccag
     1801 tgccttcgga aagattgccg ctccgtagaa tgagtccttt ctcctccacc cttaatctac
     1861 aacccagctt ccccgggaga tcctactttg atttccggtc ctcaccccac cagctgagct
     1921 tgcattcttc tttacagtct ctcaatgcac cgggctgcaa ttttgagaca caatctgcat
     1981 cttactctca attagttgac attaaaaagc tgttggcagt ggcgtggttt gcgtttgacc
     2041 ccggctcggc acactctgac atcatcttct ccaatgacaa cctgacagtg acatgcagta
     2101 gctacgatga ccgggtggtg ctggggaaaa ctggcttctc caagggcgtc cactactggg
     2161 agctgaccat agatcgctat gacaaccacc ctgatccagc atttggcgtg gctcgcatcg
     2221 atgtgatgaa ggatatgatg ttaggaaagg acgacaaggc ttgggcaatg tatgtggaca
     2281 ataaccggag ctggttcatg cacaacaact cgcacaccaa cagaactgaa ggagggatca
     2341 caaaaggggc cactatcggg gtcctcctcg acttaaacag aaagacatta acgtttttcg
     2401 tcaacaatga acagcaaggc cccatagcct ttgagaatgt ggagggcctg ttctttcctg
     2461 ccgtcagcct gaacaggaat gtacaggtca cgcttcacac tgggcttccg gtccccgact
     2521 tctactccag cagagcttcc atagcctaag ggtgagctgt ggaggcactg gctgtccctg
     2581 agaaggacag cccagagcct gcagcctcag cagaggacac agagccggta gaagaatgag
     2641 aacagctggt cctcagcaat ctccaccttt agagctccac cctttcccat cagcctctcc
     2701 gcatcgctga acccaggctc ccttcctcac ccagaaactc tacccgcgca gaggagctct
     2761 gcagcccacc gctcccgtgt gttcccactt ccgtgtgttc tttttcttta atttagtggg
     2821 tttttgttgt tgtttgcttg tttgtttgtt tttgttttaa tgtaggttga attcattttg
     2881 attcttttct gattgtgttt tggtgactta cgtacactac ctggcactgt caaaagacat
     2941 tctcctggaa actttttttc ttaagcgttt ggacaaacaa aggtgttcta ggagagcagg
     3001 taggaaagaa gccgaattta gagtttgcca tttgactcct agaatgttct tgccctggtt
     3061 cttgtcaagc aatgttagtt cttcatggct acttcttggg aggtgggcag aagtgcattt
     3121 ggcatccaga agtcttacta caccctaaag cacaaataca tcatctacac tggctcatgg
     3181 cagggtaagg accttccaga caggctctag gtactgggaa gaccaggtgg cccaatggtt
     3241 tgattcattt gactaataca agtttttaat taagaactac tacggaccag gcactgttca
     3301 agacactaga atgctgtgtt catgaacagt ctgtcttcct ggaacttata ttctatgtaa
     3361 caaagcaaca aataacgtca agttgttcta agtaccagaa aggagaggag tcaaaggagg
     3421 tgtcactgac aaaccctcag actgacgctg aacccacaca ctccagccat cacacagaca
     3481 tgtaccaacc cagtgctttt cccaccgcac taccgtaact aaggtctctg ctgccactca
     3541 ccgcagagcc cgtcttcggc agaaatgatg tcaccattgt tactcattag tgctgtgctc
     3601 agaacaagcc ttaaaagcca gaatgttaaa aaacaacatg accagaggac acaggaccca
     3661 gccacaaccc tgggcctccc gagttgcaaa ccacaacatt tacatcctca ggataaacat
     3721 gacatctcca tgtatactct ctgtgcctgt tgcaaatgag actccatccg ctcaccgctg
     3781 tcacagcctg actttctaaa gaagctcaaa tcgggtttgg aacagcgtaa gtgtggacat
     3841 cattcctagc attgacagaa gactaaccag gcttacgact cttaacggag tagataccct
     3901 tcagatgctt ctgtttgaca cgaagcttta gagaatgtag gacctggggg cggggacttc
     3961 tgattagttg tgtaaatact ttccactgag ccaagaaacc catcagtata acagtgaccg
     4021 acagaggtgg ggcgggacag ccacagtgct ttggcaaaga gtaatctatg taaatagctc
     4081 atcctctgcc catgtgctcc ctctagatca tctctgtctt tgtgtttttc tagttagaac
     4141 ctaatttact gaatgggtgc tatcctgtct atgtctgtct cgggttcctg tgactacaga
     4201 acactctcgt gggactatac tcgtttgatc tttgattgtt ccgatgagac tccatggctg
     4261 ggccgctagt tactcccttg attaaatcca tccccctggt tagagttcta gtgacttata
     4321 tcaaatagtt tacactgaac tacaactata gatgcatata actgctgtac taggagagaa
     4381 aggtcatcct cggtatgcca ataaagcatt tttatgagag gaaaaa
//
LOCUS       NR_036653                153 bp    RNA     linear   ROD 07-APR-2025
DEFINITION  Rattus norvegicus brain cytoplasmic RNA 1 (Bc1), long non-coding
            RNA.
ACCESSION   NR_036653
VERSION     NR_036653.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 153)
  AUTHORS   Gitai,D.L., Fachin,A.L., Mello,S.S., Elias,C.F., Bittencourt,J.C.,
            Leite,J.P., Passos,G.A., Garcia-Cairasco,N. and Paco-Larson,M.L.
  TITLE     The non-coding RNA BC1 is down-regulated in the hippocampus of
            Wistar Audiogenic Rat (WAR) strain after audiogenic kindling
  JOURNAL   Brain Res 1367, 114-121 (2011)
   PUBMED   20974111
  REMARK    GeneRIF: This study demonistrated that lower levels of BC1 RNA in
            the GD-hilus and significant signal ratio reduction in the stratum
            radiatum and stratum pyramidale of hippocampal CA3 subfield of
            audiogenic kindled animals.
REFERENCE   2  (bases 1 to 153)
  AUTHORS   Muslimov,I.A., Iacoangeli,A., Brosius,J. and Tiedge,H.
  TITLE     Spatial codes in dendritic BC1 RNA
  JOURNAL   J Cell Biol 175 (3), 427-439 (2006)
   PUBMED   17074884
  REMARK    GeneRIF: A BC1 KT motif encodes distal targeting via the A2 pathway
            and that architectural RNA elements, such as KT motifs, may
            function as spatial codes in neural cells.
REFERENCE   3  (bases 1 to 153)
  AUTHORS   Wang,H., Iacoangeli,A., Popp,S., Muslimov,I.A., Imataka,H.,
            Sonenberg,N., Lomakin,I.B. and Tiedge,H.
  TITLE     Dendritic BC1 RNA: functional role in regulation of translation
            initiation
  JOURNAL   J Neurosci 22 (23), 10232-10241 (2002)
   PUBMED   12451124
  REMARK    GeneRIF: a functional role of BC1 RNA as a specific repressor of
            translation and a mediator of translational control in local
            protein synthesis in nerve cell dendrites and synaptic plasticity
REFERENCE   4  (bases 1 to 153)
  AUTHORS   Martignetti,J.A. and Brosius,J.
  TITLE     Neural BC1 RNA as an evolutionary marker: guinea pig remains a
            rodent
  JOURNAL   Proc Natl Acad Sci U S A 90 (20), 9698-9702 (1993)
   PUBMED   7692450
REFERENCE   5  (bases 1 to 153)
  AUTHORS   DeChiara,T.M. and Brosius,J.
  TITLE     Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content
  JOURNAL   Proc Natl Acad Sci U S A 84 (9), 2624-2628 (1987)
   PUBMED   2437583
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1987 Jul;84(14):4895]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2024 this sequence version replaced NR_036653.2.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000001.1  209502897-209503049
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..153
                     /gene="Bc1"
                     /note="brain cytoplasmic RNA 1"
                     /db_xref="GeneID:29294"
                     /db_xref="RGD:2193"
     ncRNA           1..153
                     /ncRNA_class="lncRNA"
                     /gene="Bc1"
                     /product="brain cytoplasmic RNA 1"
                     /db_xref="GeneID:29294"
                     /db_xref="RGD:2193"
     exon            1..153
                     /gene="Bc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttgggg atttagctca gtggtagagc gcttgcctag caagcgcaag gccctgggtt
       61 cggtcctcag ctccgaaaaa aaaaaaaaaa aaaaaaaaga caaaataaca aaaagaccaa
      121 aaaaaaacaa ggtaactggc acacacaacc ttt
//
LOCUS       NM_001437564            3137 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus RAS protein activator like 1 (Rasal1), transcript
            variant 2, mRNA.
ACCESSION   NM_001437564
VERSION     NM_001437564.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Hong,Y., Han,Y.Q., Wang,Y.Z., Gao,J.R., Li,Y.X., Liu,Q. and
            Xia,L.Z.
  TITLE     Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by
            regulating the expression of RASAL1/ERK1/2 signal pathway
  JOURNAL   J Ethnopharmacol 192, 114-122 (2016)
   PUBMED   27396351
  REMARK    GeneRIF: Paridis rhizoma sapoinins attenuate CCl4-induced liver
            fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Tao,H., Huang,C., Yang,J.J., Ma,T.T., Bian,E.B., Zhang,L., Lv,X.W.,
            Jin,Y. and Li,J.
  TITLE     MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in
            rats
  JOURNAL   Toxicology 290 (2-3), 327-333 (2011)
   PUBMED   22056649
  REMARK    GeneRIF: hypermethylation of RASAL1 is associated with the
            perpetuation of fibroblast activation and fibrogenesis in the liver
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 8, 2025 this sequence version replaced NM_001437564.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2410031.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840109,
                                           SAMN12840117 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000012.1  41573595-41573908   c
            315-371             JAXUCZ010000012.1  41570255-41570311   c
            372-433             JAXUCZ010000012.1  41567956-41568017   c
            434-563             JAXUCZ010000012.1  41562570-41562699   c
            564-645             JAXUCZ010000012.1  41559631-41559712   c
            646-777             JAXUCZ010000012.1  41559413-41559544   c
            778-863             JAXUCZ010000012.1  41558705-41558790   c
            864-981             JAXUCZ010000012.1  41557983-41558100   c
            982-1135            JAXUCZ010000012.1  41557705-41557858   c
            1136-1200           JAXUCZ010000012.1  41557299-41557363   c
            1201-1313           JAXUCZ010000012.1  41556938-41557050   c
            1314-1506           JAXUCZ010000012.1  41555495-41555687   c
            1507-1650           JAXUCZ010000012.1  41551502-41551645   c
            1651-1795           JAXUCZ010000012.1  41550265-41550409   c
            1796-1968           JAXUCZ010000012.1  41547288-41547460   c
            1969-2106           JAXUCZ010000012.1  41546254-41546391   c
            2107-2242           JAXUCZ010000012.1  41546041-41546176   c
            2243-2363           JAXUCZ010000012.1  41544782-41544902   c
            2364-2440           JAXUCZ010000012.1  41542798-41542874   c
            2441-3137           JAXUCZ010000012.1  41541864-41542560   c
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3137
                     /gene="Rasal1"
                     /note="RAS protein activator like 1"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
     exon            1..314
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Rasal1"
                     /note="upstream in-frame stop codon"
     CDS             250..2547
                     /gene="Rasal1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rasGAP-activating-like protein 1; RAS protein activator
                     like 1 (GAP1 like)"
                     /codon_start=1
                     /product="rasGAP-activating-like protein 1 isoform 2"
                     /protein_id="NP_001424493.2"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
                     /translation="MAKSGSLSIRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARHDD
                     IIGKISLSKEAITADPRGIDSWINLSRVDPDEEVQGEVCLAVKLLEDARGRCLRCHVR
                     QARDLAPRDISGTSDPFARVFWGSRSLETSTIKKTRFPHWDEVLELREAPGTTSPLRV
                     ELWDWDMVGKNDFLGMVEFTPQTLQQKPPNGWFRLLPFPRAEDSGGSLGALRLKVRLT
                     EDRVLPSQYYQPLMELLLESVQGPAEEDTTSPLALLEELASGDCRQDLATKLVKLFLG
                     RGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKSMEQFMKLVGMRYLHEVLRPVISR
                     VFEEKKYMELDPSKMDLNRSRRISFKGTPTEEQVRETSLGLLTGYLGSVVDAIVSSAG
                     RCPLALRLAFKQLQQCVEKRFPGMEHQDVKYLATSGFLFLRFFAPAILTPKLFDLRDH
                     HADPQTSRSLLLLAKVCAVQSIGNLGQQLGQGKEQWLAPLHPFLLQSISRVRDFLDQL
                     VDVDGDEEAGGSTCALVQPSTIVREGFLLKRKEEPASLATRFAFKKRYFRLSGRDLSY
                     SKTPEWQVHSSIPLSCIRAVERVDEGAFQLPHVMQVVTQDGTGASHTTYLQCKNVNDL
                     NQWLSALRKASAPNPGKLAACHPGAFRSGRWTCCLQAERSAVGCSRTHSAVTLGDWSD
                     PLDPDAEAQMVYRQLLLGRDQLRLKLLEDSSLDTAPDVDPGKDSSAVDGPCAEVLAQQ
                     REATTRLLQVLEDLEQAHEEFQKRG"
     misc_feature    265..513
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    265..513
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    535..897
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    535..897
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    919..1785
                     /gene="Rasal1"
                     /note="Ras GTPase Activating Domain; Region: RasGAP;
                     cl02569"
                     /db_xref="CDD:470620"
     misc_feature    919..1785
                     /gene="Rasal1"
                     /note="Ras GTPase Activating Domain; Region: RasGAP;
                     cl02569"
                     /db_xref="CDD:470620"
     misc_feature    order(1036..1038,1144..1146,1150..1152,1156..1161,
                     1165..1167,1174..1176,1186..1188,1519..1521,1543..1548,
                     1555..1560,1567..1569,1630..1632,1639..1644,1657..1659,
                     1669..1671,1675..1677,1696..1701)
                     /gene="Rasal1"
                     /note="RAS interface [polypeptide binding]; other site"
                     /db_xref="CDD:213337"
     misc_feature    order(1036..1038,1144..1146,1150..1152,1156..1161,
                     1165..1167,1174..1176,1186..1188,1519..1521,1543..1548,
                     1555..1560,1567..1569,1630..1632,1639..1644,1657..1659,
                     1669..1671,1675..1677,1696..1701)
                     /gene="Rasal1"
                     /note="RAS interface [polypeptide binding]; other site"
                     /db_xref="CDD:213337"
     misc_feature    1795..2208
                     /gene="Rasal1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    1795..2208
                     /gene="Rasal1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    2182..2268
                     /gene="Rasal1"
                     /note="BTK motif; Region: BTK; pfam00779"
                     /db_xref="CDD:459937"
     misc_feature    2182..2268
                     /gene="Rasal1"
                     /note="BTK motif; Region: BTK; pfam00779"
                     /db_xref="CDD:459937"
     exon            315..371
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..433
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..563
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..645
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..777
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..863
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..981
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1135
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1200
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1313
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1506
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1650
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1795
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1968
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2106
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2242
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2363
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2440
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..3137
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgccagg ctcagcctgc ccagatcgca gcgcacagct acctgtagct ctggacgcat
       61 gtccccttcc gggacccagc acttctccct cctagccctg catccagccc actcgcaccc
      121 cagacccgta cctgtgggaa cccgtggact gcgtgcttgg cccgccgctg atgacatgta
      181 gggtcacctc ctggtccagc ctcggaacct cggcagactc cttgcctgga aagtttggga
      241 ctgtgcgcca tggccaagag cggctctctg agtatccgcg tggtggaggg acgggcgctg
      301 cccgccaagg acgtgtctgg gagcagtgac ccctactgtc ttgtgaaagt ggatgatgag
      361 gtggtggcca gacacgacga catcattggg aagatctcct tgagcaaaga ggcgatcaca
      421 gcggaccctc gagggattga cagctggatc aacctgagcc gagtggatcc agatgaggaa
      481 gtgcagggtg aggtctgcct ggctgtgaag ctgctggagg atgctcgggg gagatgcctc
      541 cgctgccacg tgagacaggc cagggacctg gcccctcggg acatctctgg cacatcggac
      601 ccatttgccc gtgtgttctg gggcagccgt agtttggaaa cttcgaccat caagaagacc
      661 cgattcccac attgggatga ggtgctggaa ctacgagagg ctccgggaac cacatccccg
      721 ctgcgagtgg aactctggga ttgggacatg gtgggcaaaa atgacttcct gggcatggtg
      781 gaattcaccc cacagaccct ccagcagaag ccacccaatg gctggttccg tctcctgcct
      841 tttcctagag ctgaggattc tggggggagc ctgggtgccc tgcggctgaa ggtgcgcctc
      901 actgaggacc gggtcctgcc ttcccagtac taccagcctc tcatggaact gcttctggag
      961 tccgtgcaag ggccagccga ggaggacacc accagccccc tggcattgct agaggagttg
     1021 gcctctgggg actgtcgtca ggaccttgcc accaaactgg tgaagctttt cctgggccgg
     1081 ggcctggctg ggccctttct agattacctc acaaggcgtg aggtggcacg aaccaatgac
     1141 cccaacaccc tcttccgttc taactccttg gcatccaagt cgatggaaca gttcatgaaa
     1201 ctcgtgggca tgcgctacct gcatgaggtc ctgaggccgg tgatcagccg cgtcttcgag
     1261 gagaagaaat atatggagct ggacccttcc aagatggacc tgaaccgctc ccggagaatc
     1321 tccttcaagg gcacacccac ggaggagcag gtgcgggaga ccagcctggg gctgctgacc
     1381 ggatacctgg ggtccgttgt ggacgccatc gtgagctctg ccgggcgctg cccacttgcc
     1441 ctgcgcttag cctttaagca actccagcag tgtgtggaga agcgcttccc tgggatggag
     1501 catcaggacg tgaagtactt ggccactagc ggcttcctct ttctgcggtt ctttgcgccc
     1561 gccatcctca caccgaagct gtttgacctc agagaccacc acgcagaccc ccagaccagc
     1621 cgctccctgc tgctgcttgc caaggtctgt gctgtgcaga gcattggaaa cctgggccag
     1681 cagctgggcc agggcaaaga gcagtggcta gcccccctcc atcccttcct gctgcagagc
     1741 atctcacgtg tgagggactt cctggaccag ctggtggatg tggatgggga tgaggaggct
     1801 gggggatcaa cctgcgccct ggtccaaccc tcaacaattg ttcgagaagg ctttctgctg
     1861 aagcgcaagg aggagcctgc aagcctggcc acccgctttg ccttcaagaa gcgctacttc
     1921 cgactgagtg ggcgggacct ctcctactct aagactcctg agtggcaggt tcactcatcc
     1981 atcccgttgt cctgcatccg ggctgtggag cgtgtggatg agggtgcctt ccaactgcca
     2041 catgtcatgc aggtggtgac acaggatggc accggggcat cacacaccac ctacctccag
     2101 tgcaagaacg tgaatgacct caatcaatgg ctgtcagccc tgcgcaaagc cagcgccccc
     2161 aacccgggca agctggctgc ttgtcaccct ggtgccttcc gcagcgggcg ctggacctgc
     2221 tgcctccagg ccgagcgctc agctgttggc tgtagccgca cacactcagc tgtcacgctg
     2281 ggagactgga gtgacccact ggatcctgac gccgaagccc agatggtgta tcgccagctg
     2341 ctcctgggcc gagaccagct caggctgaaa ctgctggagg actccagcct ggacacagct
     2401 ccagatgtgg accctgggaa ggactccagt gctgtagatg ggccctgtgc tgaggttcta
     2461 gcccagcaga gggaggccac cacccgtctg ctgcaggtac ttgaagactt ggagcaagcc
     2521 catgaggaat tccagaaacg gggctagggg aaagtggccc tctaggacac tggatgctga
     2581 gaaggtgcca gagccagttg gggacagagc cacggggctt ccctgagctt actttggcct
     2641 aggcatcttc attgtcgtgg cttggagcct cccaaagtgt ggtcctgtgt gccctgtagc
     2701 cagccagggc ataggaacct ttaagagggc ccagccttgt accgactgac caaacctcac
     2761 ttccttctct gagcctggag cctcagcttc actggataca gctcctccag taccggtgga
     2821 acccataccg gtggcaccca tctcacccca agctgctggg tgcagctgta cctgaactcc
     2881 aatcctggct gatgcagaaa aacactcaat atgcttgacc aggaacttcc cgtgttatca
     2941 cttccgtggg ccccggtgac ctcacagatc cttctgtacc ccactttcat ctggcagtcc
     3001 cggcctcaag cttctgggac ccggtgttct cggaagaacg gactgggagc ccagcatgcc
     3061 aatttggagc ctcgaagctg gacacgggct cttcctccct cctataccct gtataaagtg
     3121 acgtgtgagc atgctta
//
LOCUS       NM_001437678            2416 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 7, mRNA.
ACCESSION   NM_001437678 XM_006244992
VERSION     NM_001437678.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_006244992.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2291159.1,
                                           SRR26360194.619984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000009.1  66814230-66814304
            76-125              JAXUCZ010000009.1  66839657-66839706
            126-210             JAXUCZ010000009.1  66873112-66873196
            211-271             JAXUCZ010000009.1  66898226-66898286
            272-380             JAXUCZ010000009.1  66921419-66921527
            381-430             JAXUCZ010000009.1  66924616-66924665
            431-677             JAXUCZ010000009.1  66927640-66927886
            678-884             JAXUCZ010000009.1  66942416-66942622
            885-1020            JAXUCZ010000009.1  66943912-66944047
            1021-1079           JAXUCZ010000009.1  66965594-66965652
            1080-1189           JAXUCZ010000009.1  66979059-66979168
            1190-1292           JAXUCZ010000009.1  66981573-66981675
            1293-1513           JAXUCZ010000009.1  66984115-66984335
            1514-2416           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2416
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..75
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            76..125
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            126..210
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             173..1909
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 1 is encoded by transcript variant 7;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 1"
                     /protein_id="NP_001424607.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITEGSRLLQQKMSLDGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVK
                     SNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAA
                     FAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAEL
                     RAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLP
                     LLNTHAVASGKQGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNG
                     PSNQRRRFNPQYHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAK
                     NQEAPLGTKAPEAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEA
                     TVLSVPAVTLVA"
     misc_feature    407..1336
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    407..1336
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            211..271
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            272..380
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            381..430
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            431..677
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            678..884
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1020
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1079
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1189
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1292
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1513
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2416
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcctctc ccgactactg cactcccagg cagaaacacc actggcggat gccacgggag
       61 gctcggggca gctcggagac tccagaagcc aggctgcttt cgggaacaac tctgtggatt
      121 cccaggtcct gtggtcagag ctgaaggccc cggttagtcc cgctgcaagt acatggctgg
      181 aacacaggaa accggagctt caacgagcaa ggcttatacc cctagaagga agatggctga
      241 actcaacact catgtgaatg tcaaagagaa gatctacgca gttagatcag ttgttccgaa
      301 caaaagcaat aatgaaattg tcctggtgct ccaacagttt gattttaatg tggataaagc
      361 cgtgcaagcc tttgtggacg gcagtgctat tcaggttctt aaagaatgga gcatgacggg
      421 gaaaaagaag aataacaaaa gaaaaagaag caaatccaag cagcatcaag gcaacaaaga
      481 tgctaaggac aagggggaga ggccggaggt ggggcccctg cagccccagg caccactggt
      541 acaaaatggt cacatgaatg gctgtgaaaa ggacagctca tcccctgact ctgccagaga
      601 aaaactggcc ctcacaccac gtgagaaaaa gatctcaata ctggaggaac caccaagggc
      661 tcagcgtggg atcacagaag gcagcagact actgcagcag aaaatgtcct tagatgggaa
      721 ccccaaagct attcatggac catcagagag gtcagatggc ctacagtggt cagctgggca
      781 gccttgtaac ccaagcaagc ctaaggcaaa aacatctcct gttaagtcca atgcccctgc
      841 agctcatctt gaaataaagc cagatgagct ggcaaagaaa agaggtccaa atattgagaa
      901 atcggtgaag gatctgcagc gctgcactgt ttctctgacg agataccgag tcatgatcaa
      961 ggaagaggtg gacagttctg tgaagaagat caaagcagct tttgctgagc tacacaactg
     1021 catcattgac aaagaagttt cactgatggc agagatggat aaagttaaag aagaagccat
     1081 ggacatcctg actgcccgtc agaagaaggc agaggagctg aagcgactga ctgatctagc
     1141 cagtcaaatg gcagagatgc agctggccga actcagagct gaaattaagc actttgtcag
     1201 cgaacgcaaa tatgatgaag agctagggaa agccgcccgc ttctcctgcg acattgaaca
     1261 gctgaaagcc caaatcctga tctgcggaga aatcacacat ccaaagaaca actattcctc
     1321 aagaactccc tgcagctccc tgttgcctct gctgaacact catgcggtag cttccgggaa
     1381 gcaggggaat ttttcccgga agtcatccgg tcacaacaag cccaatgagg ggaaagcagc
     1441 gaaccccaaa atggtgagcg gtcttcccag cactgccgat gcatgtcagc agaccatgcc
     1501 tactaacaag cagcagaatg gaccttccaa ccaaagacga agatttaatc cacagtatca
     1561 caacaggcta aatggtccag ccaagtcaca gggcagtggt aatgaagctg atcccatggt
     1621 gaagagcaac aaccgacatg aacacagaag acagccacat aatggttttc gtcccaaaaa
     1681 caaaggtggt gccaaaaacc aagaggcccc cttggggaca aaggccccag aggccccacc
     1741 acattctgaa aaggcccgtc gaaggcagca cgctgcagac aacttagaga ccaggccttt
     1801 ccggggtaat gttggtaggg tttcacagtg caatctttgt cccactagaa tagaagtttc
     1861 cacagaggcc acggttctct cagtcccagc tgtgacgctg gtggcctgag ctgggaagga
     1921 agagagcagg ttttgcctgg ttttggttcc ctgcccaagg tgctgaccca attcgctgcc
     1981 aaaagagagt caatcagaat atacaaacct gtatgtttgt gtcgttctct cgcaatcatt
     2041 tttactaatc ctagtactct gctctagctt gcttcataac tcccatggct ttgcttgatc
     2101 tgttgtcgct tctcctcatc aagactttgc atcatgttag ccagccagta tttacccatt
     2161 gttaggaaaa tcgagatgtg gctgaagatc agaggctcag ttagcaacct acgttgtagc
     2221 tgtgatgtcg acccattggt tgtctttaga gagttaatgt tgaaacaaga aattcttgat
     2281 cagacaaacg tgatctgctg aagacacatg tgcttttgta gaatttaaca tctggtgttt
     2341 ttctgaaata ttatataaat atatatataa acatatattg ctttatttga aacaaattaa
     2401 aatatgctgc atttga
//
LOCUS       NM_001437676            2429 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 5, mRNA.
ACCESSION   NM_001437676 XM_039083628
VERSION     NM_001437676.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_039083628.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.91717.1,
                                           SRR26360194.791331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000009.1  66814791-66814878
            89-138              JAXUCZ010000009.1  66839657-66839706
            139-223             JAXUCZ010000009.1  66873112-66873196
            224-284             JAXUCZ010000009.1  66898226-66898286
            285-393             JAXUCZ010000009.1  66921419-66921527
            394-443             JAXUCZ010000009.1  66924616-66924665
            444-690             JAXUCZ010000009.1  66927640-66927886
            691-897             JAXUCZ010000009.1  66942416-66942622
            898-1033            JAXUCZ010000009.1  66943912-66944047
            1034-1092           JAXUCZ010000009.1  66965594-66965652
            1093-1202           JAXUCZ010000009.1  66979059-66979168
            1203-1305           JAXUCZ010000009.1  66981573-66981675
            1306-1526           JAXUCZ010000009.1  66984115-66984335
            1527-2429           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2429
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..88
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            89..138
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            139..223
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    168..170
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             186..1922
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 1 is encoded by transcript variant 5;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 1"
                     /protein_id="NP_001424605.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITEGSRLLQQKMSLDGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVK
                     SNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAA
                     FAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAEL
                     RAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLP
                     LLNTHAVASGKQGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNG
                     PSNQRRRFNPQYHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAK
                     NQEAPLGTKAPEAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEA
                     TVLSVPAVTLVA"
     misc_feature    420..1349
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    420..1349
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            224..284
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            285..393
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            394..443
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            444..690
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            691..897
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1033
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1092
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1202
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1305
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1526
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..2429
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgaacgg atacaaaacc cagggaggcg tgatcggcgg cgtgtgtgca agcccgagcg
       61 aggggcgccg gcggggtgtg tgctcctgga gactccagaa gccaggctgc tttcgggaac
      121 aactctgtgg attcccaggt cctgtggtca gagctgaagg ccccggttag tcccgctgca
      181 agtacatggc tggaacacag gaaaccggag cttcaacgag caaggcttat acccctagaa
      241 ggaagatggc tgaactcaac actcatgtga atgtcaaaga gaagatctac gcagttagat
      301 cagttgttcc gaacaaaagc aataatgaaa ttgtcctggt gctccaacag tttgatttta
      361 atgtggataa agccgtgcaa gcctttgtgg acggcagtgc tattcaggtt cttaaagaat
      421 ggagcatgac ggggaaaaag aagaataaca aaagaaaaag aagcaaatcc aagcagcatc
      481 aaggcaacaa agatgctaag gacaaggggg agaggccgga ggtggggccc ctgcagcccc
      541 aggcaccact ggtacaaaat ggtcacatga atggctgtga aaaggacagc tcatcccctg
      601 actctgccag agaaaaactg gccctcacac cacgtgagaa aaagatctca atactggagg
      661 aaccaccaag ggctcagcgt gggatcacag aaggcagcag actactgcag cagaaaatgt
      721 ccttagatgg gaaccccaaa gctattcatg gaccatcaga gaggtcagat ggcctacagt
      781 ggtcagctgg gcagccttgt aacccaagca agcctaaggc aaaaacatct cctgttaagt
      841 ccaatgcccc tgcagctcat cttgaaataa agccagatga gctggcaaag aaaagaggtc
      901 caaatattga gaaatcggtg aaggatctgc agcgctgcac tgtttctctg acgagatacc
      961 gagtcatgat caaggaagag gtggacagtt ctgtgaagaa gatcaaagca gcttttgctg
     1021 agctacacaa ctgcatcatt gacaaagaag tttcactgat ggcagagatg gataaagtta
     1081 aagaagaagc catggacatc ctgactgccc gtcagaagaa ggcagaggag ctgaagcgac
     1141 tgactgatct agccagtcaa atggcagaga tgcagctggc cgaactcaga gctgaaatta
     1201 agcactttgt cagcgaacgc aaatatgatg aagagctagg gaaagccgcc cgcttctcct
     1261 gcgacattga acagctgaaa gcccaaatcc tgatctgcgg agaaatcaca catccaaaga
     1321 acaactattc ctcaagaact ccctgcagct ccctgttgcc tctgctgaac actcatgcgg
     1381 tagcttccgg gaagcagggg aatttttccc ggaagtcatc cggtcacaac aagcccaatg
     1441 aggggaaagc agcgaacccc aaaatggtga gcggtcttcc cagcactgcc gatgcatgtc
     1501 agcagaccat gcctactaac aagcagcaga atggaccttc caaccaaaga cgaagattta
     1561 atccacagta tcacaacagg ctaaatggtc cagccaagtc acagggcagt ggtaatgaag
     1621 ctgatcccat ggtgaagagc aacaaccgac atgaacacag aagacagcca cataatggtt
     1681 ttcgtcccaa aaacaaaggt ggtgccaaaa accaagaggc ccccttgggg acaaaggccc
     1741 cagaggcccc accacattct gaaaaggccc gtcgaaggca gcacgctgca gacaacttag
     1801 agaccaggcc tttccggggt aatgttggta gggtttcaca gtgcaatctt tgtcccacta
     1861 gaatagaagt ttccacagag gccacggttc tctcagtccc agctgtgacg ctggtggcct
     1921 gagctgggaa ggaagagagc aggttttgcc tggttttggt tccctgccca aggtgctgac
     1981 ccaattcgct gccaaaagag agtcaatcag aatatacaaa cctgtatgtt tgtgtcgttc
     2041 tctcgcaatc atttttacta atcctagtac tctgctctag cttgcttcat aactcccatg
     2101 gctttgcttg atctgttgtc gcttctcctc atcaagactt tgcatcatgt tagccagcca
     2161 gtatttaccc attgttagga aaatcgagat gtggctgaag atcagaggct cagttagcaa
     2221 cctacgttgt agctgtgatg tcgacccatt ggttgtcttt agagagttaa tgttgaaaca
     2281 agaaattctt gatcagacaa acgtgatctg ctgaagacac atgtgctttt gtagaattta
     2341 acatctggtg tttttctgaa atattatata aatatatata taaacatata ttgctttatt
     2401 tgaaacaaat taaaatatgc tgcatttga
//
LOCUS       NM_001437675            2223 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 3, mRNA.
ACCESSION   NM_001437675 XM_039083630
VERSION     NM_001437675.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_039083630.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.25664.1,
                                           SRR26643297.31713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000009.1  66815013-66815101
            90-139              JAXUCZ010000009.1  66839657-66839706
            140-224             JAXUCZ010000009.1  66873112-66873196
            225-285             JAXUCZ010000009.1  66898226-66898286
            286-394             JAXUCZ010000009.1  66921419-66921527
            395-444             JAXUCZ010000009.1  66924616-66924665
            445-691             JAXUCZ010000009.1  66927640-66927886
            692-827             JAXUCZ010000009.1  66943912-66944047
            828-886             JAXUCZ010000009.1  66965594-66965652
            887-996             JAXUCZ010000009.1  66979059-66979168
            997-1099            JAXUCZ010000009.1  66981573-66981675
            1100-1320           JAXUCZ010000009.1  66984115-66984335
            1321-2223           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2223
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..89
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            90..139
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            140..224
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             187..1716
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 3 is encoded by transcript variant 3;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 3"
                     /protein_id="NP_001424604.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDK
                     EVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSER
                     KYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLPLLNTHAVASGK
                     QGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNGPSNQRRRFNPQ
                     YHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAKNQEAPLGTKAP
                     EAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEATVLSVPAVTLV
                     A"
     misc_feature    421..1143
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    421..1143
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            225..285
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            286..394
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            395..444
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            445..691
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            692..827
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            828..886
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            887..996
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1099
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1320
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..2223
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgctctc cctccgctcg ccctccgcgc cgcaggggcc gccagcgctg cgccccggcc
       61 cgggacagag cggccgcact cgcaccgagg agactccaga agccaggctg ctttcgggaa
      121 caactctgtg gattcccagg tcctgtggtc agagctgaag gccccggtta gtcccgctgc
      181 aagtacatgg ctggaacaca ggaaaccgga gcttcaacga gcaaggctta tacccctaga
      241 aggaagatgg ctgaactcaa cactcatgtg aatgtcaaag agaagatcta cgcagttaga
      301 tcagttgttc cgaacaaaag caataatgaa attgtcctgg tgctccaaca gtttgatttt
      361 aatgtggata aagccgtgca agcctttgtg gacggcagtg ctattcaggt tcttaaagaa
      421 tggagcatga cggggaaaaa gaagaataac aaaagaaaaa gaagcaaatc caagcagcat
      481 caaggcaaca aagatgctaa ggacaagggg gagaggccgg aggtggggcc cctgcagccc
      541 caggcaccac tggtacaaaa tggtcacatg aatggctgtg aaaaggacag ctcatcccct
      601 gactctgcca gagaaaaact ggccctcaca ccacgtgaga aaaagatctc aatactggag
      661 gaaccaccaa gggctcagcg tgggatcaca ggtccaaata ttgagaaatc ggtgaaggat
      721 ctgcagcgct gcactgtttc tctgacgaga taccgagtca tgatcaagga agaggtggac
      781 agttctgtga agaagatcaa agcagctttt gctgagctac acaactgcat cattgacaaa
      841 gaagtttcac tgatggcaga gatggataaa gttaaagaag aagccatgga catcctgact
      901 gcccgtcaga agaaggcaga ggagctgaag cgactgactg atctagccag tcaaatggca
      961 gagatgcagc tggccgaact cagagctgaa attaagcact ttgtcagcga acgcaaatat
     1021 gatgaagagc tagggaaagc cgcccgcttc tcctgcgaca ttgaacagct gaaagcccaa
     1081 atcctgatct gcggagaaat cacacatcca aagaacaact attcctcaag aactccctgc
     1141 agctccctgt tgcctctgct gaacactcat gcggtagctt ccgggaagca ggggaatttt
     1201 tcccggaagt catccggtca caacaagccc aatgagggga aagcagcgaa ccccaaaatg
     1261 gtgagcggtc ttcccagcac tgccgatgca tgtcagcaga ccatgcctac taacaagcag
     1321 cagaatggac cttccaacca aagacgaaga tttaatccac agtatcacaa caggctaaat
     1381 ggtccagcca agtcacaggg cagtggtaat gaagctgatc ccatggtgaa gagcaacaac
     1441 cgacatgaac acagaagaca gccacataat ggttttcgtc ccaaaaacaa aggtggtgcc
     1501 aaaaaccaag aggccccctt ggggacaaag gccccagagg ccccaccaca ttctgaaaag
     1561 gcccgtcgaa ggcagcacgc tgcagacaac ttagagacca ggcctttccg gggtaatgtt
     1621 ggtagggttt cacagtgcaa tctttgtccc actagaatag aagtttccac agaggccacg
     1681 gttctctcag tcccagctgt gacgctggtg gcctgagctg ggaaggaaga gagcaggttt
     1741 tgcctggttt tggttccctg cccaaggtgc tgacccaatt cgctgccaaa agagagtcaa
     1801 tcagaatata caaacctgta tgtttgtgtc gttctctcgc aatcattttt actaatccta
     1861 gtactctgct ctagcttgct tcataactcc catggctttg cttgatctgt tgtcgcttct
     1921 cctcatcaag actttgcatc atgttagcca gccagtattt acccattgtt aggaaaatcg
     1981 agatgtggct gaagatcaga ggctcagtta gcaacctacg ttgtagctgt gatgtcgacc
     2041 cattggttgt ctttagagag ttaatgttga aacaagaaat tcttgatcag acaaacgtga
     2101 tctgctgaag acacatgtgc ttttgtagaa tttaacatct ggtgtttttc tgaaatatta
     2161 tataaatata tatataaaca tatattgctt tatttgaaac aaattaaaat atgctgcatt
     2221 tga
//
LOCUS       NM_001437660            5118 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus calcium responsive transcription factor (Carf),
            transcript variant 2, mRNA.
ACCESSION   NM_001437660
VERSION     NM_001437660.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5118)
  AUTHORS   Zheng,F., Zhou,X., Luo,Y., Xiao,H., Wayman,G. and Wang,H.
  TITLE     Regulation of brain-derived neurotrophic factor exon IV
            transcription through calcium responsive elements in cortical
            neurons
  JOURNAL   PLoS One 6 (12), e28441 (2011)
   PUBMED   22174809
REFERENCE   2  (bases 1 to 5118)
  AUTHORS   Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K.,
            Reddel,R.R., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF is a novel protein that cooperates with mouse p19ARF (human
            p14ARF) in activating p53
  JOURNAL   J Biol Chem 277 (40), 37765-37770 (2002)
   PUBMED   12154087
REFERENCE   3  (bases 1 to 5118)
  AUTHORS   Tao,X., West,A.E., Chen,W.G., Corfas,G. and Greenberg,M.E.
  TITLE     A calcium-responsive transcription factor, CaRF, that regulates
            neuronal activity-dependent expression of BDNF
  JOURNAL   Neuron 33 (3), 383-395 (2002)
   PUBMED   11832226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.50740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000009.1  68996617-68996660
            45-159              JAXUCZ010000009.1  69003480-69003594
            160-387             JAXUCZ010000009.1  69007733-69007960
            388-448             JAXUCZ010000009.1  69020417-69020477
            449-578             JAXUCZ010000009.1  69021475-69021604
            579-663             JAXUCZ010000009.1  69023524-69023608
            664-853             JAXUCZ010000009.1  69027269-69027458
            854-974             JAXUCZ010000009.1  69030122-69030242
            975-1118            JAXUCZ010000009.1  69032846-69032989
            1119-1352           JAXUCZ010000009.1  69034974-69035207
            1353-1515           JAXUCZ010000009.1  69037446-69037608
            1516-1579           JAXUCZ010000009.1  69039185-69039248
            1580-1710           JAXUCZ010000009.1  69040403-69040533
            1711-1933           JAXUCZ010000009.1  69041024-69041246
            1934-5118           JAXUCZ010000009.1  69043296-69046480
FEATURES             Location/Qualifiers
     source          1..5118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..5118
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="calcium responsive transcription factor"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
     exon            1..44
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            45..159
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            160..387
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2043
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 8; calcium-response factor; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 8
                     protein"
                     /codon_start=1
                     /product="calcium-responsive transcription factor isoform
                     2"
                     /protein_id="NP_001424589.1"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
                     /translation="MDSGDPSLGQNDPPTILPNTVPETHDPLTSQNIPETLTDTQALH
                     EEQFHLLDQNGQPIQYDLQSLGNSTAQMTGMEQVVIPQESFADVCSPPGVSEEKPIGG
                     SLPAVSTDALEDSASSYSLHSQASLVGPRKSGTRTLEEPLLAPLQPLSCNTPMWACRL
                     RSCEKIGDSYRGYCVSETELESVLTFHKQQTQTVWGTRQSPSPAKPATRLMWKSQYVP
                     YDGIPFVNAGSRAVVMECQYGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQK
                     FPDYRVPTDPQIDRKTIRMEQEKAFTMLKKNLVDAGGVLRWYVQLPTQQAHQYHEPET
                     PGVPLSPSPFPMSPLEEEEAIIRDENCVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQ
                     LRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQ
                     WTTDSGNILRETVTVTFAEGNLLKEPITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKI
                     FTHLQSQNLGTDTCLPENSSTASPMGSLPESVQNLVAVDQLVGGEDAEDAGNLEGNVK
                     RTLLGDAHTIPIHILDSHPALVEEDTLSMNQVKQEPNEPTLSTEAKTLLDCKNVSAT"
     misc_feature    772..1470
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     misc_feature    772..1470
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     exon            388..448
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            449..578
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            579..663
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            664..853
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            854..974
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1118
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1352
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1515
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1579
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1710
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1933
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..5118
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgtggt ggtctccacg gcggggcctc ggagccaaga cgaggtatgg tgagaccaac
       61 agacgaagag acgattgcca ttgggaagac agcccatttt tcacagttct cgaaaggagt
      121 gggcatgctg taccaccaag tgccaacaat aacaccaagc gtctgacctg tatggactct
      181 ggggatcctt cccttggaca aaatgatccc cctaccattt tgcccaatac tgttcctgaa
      241 acacatgatc cactcacatc acagaatata ccagagacac tgactgacac acaggccctt
      301 catgaagagc aatttcatct tttggaccaa aatgggcagc ctattcaata tgaccttcag
      361 tctttgggaa attctactgc acaaatgaca gggatggagc aagtggttat acctcaggag
      421 tcgtttgcag acgtgtgtag tcctccaggt gtctctgaag agaagcccat tggtgggagt
      481 ttgccagctg taagcacaga tgctctagaa gacagcgcca gtagctacag tcttcactca
      541 caagcatccc tcgtgggacc cagaaagtca gggaccagaa ctcttgaaga acctttgctg
      601 gcccctctcc agccactttc ttgtaacaca cccatgtggg cctgccgtct taggagttgt
      661 gagaaaattg gagattccta ccgtggctac tgtgtaagtg agactgaatt agaaagcgtc
      721 ctaacttttc acaagcagca aacacagact gtctggggca ctcgccaatc tccaagccca
      781 gccaaacctg ccacacgctt gatgtggaag tctcagtatg tcccctatga cggcatcccg
      841 tttgtcaatg caggaagtcg agctgttgta atggagtgtc agtatggacc aaggagaaaa
      901 ggttttcagt taaaaaaaat cagcgagcaa gaaagtaggt cttgtcatct ctacaaagct
      961 acttgtccag ccaggatata cattaaaaag gtacagaaat ttcctgacta tagagtacct
     1021 actgaccccc agattgatag gaagacaatc cggatggagc aggagaaagc cttcactatg
     1081 ctgaagaaga acctggtgga cgcgggcggt gtccttcggt ggtatgtgca gttacctacg
     1141 cagcaagctc accagtatca tgaaccagag actcccggtg tccctttgtc accgtcacct
     1201 ttccctatgt ctcctcttga ggaagaggag gctataatca gagatgagaa ctgtgtgttg
     1261 ccctctcgtc tccacccgca agtagcgcat aagatccagg agttagtgtc ccagggagtg
     1321 gggcaagtgt atgcagtgag gaagcagcta agaaaatttg tggaaagaga actgttcaaa
     1381 cctgatgagg tacctgaaag acataattta tctttttttc caactgtaaa tgatatcaaa
     1441 aatcatatcc acgaggtaca gaaatccttg cagactggag atgtggtata taactcagag
     1501 attattccag caacgcttca gtggactaca gatagtggaa atatcctcag agagactgta
     1561 acagttacat ttgcagaagg aaatttacta aaagagccga ttaccagcaa aatggggaca
     1621 agtcagacac aaacttcttt gtctccagaa ccacttccct tgctctcccc actttcttca
     1681 tttcagccca aaatatttac acatttacag agtcaaaacc ttggaacaga cacttgccta
     1741 cccgagaaca gcagcacggc ctctcccatg ggcagtcttc cggagtcagt tcagaaccta
     1801 gttgcagtgg atcagctggt gggaggtgag gatgctgagg atgctgggaa tctggaagga
     1861 aatgtaaaga ggactctgtt gggagatgca cacaccattc caatacacat cctagacagc
     1921 catccagctc ttgttgaaga agatactctg tccatgaacc aagttaaaca agaacccaat
     1981 gagccaacac tgtctacaga agcaaagact ttgctggact gtaaaaacgt gtctgctaca
     2041 taaatatttc aagtttttca gaatttacag atctggcccc ttctgatgtc ttagaaggtg
     2101 aagattgtca gggcatggta tatcactgga ccagagtgga tgatgggcag ttttgactta
     2161 aaattcaaat atttgttgca aattctatat ttgtatttcc cttaagaaat attttacttt
     2221 attttgtatt cctacaattt ttttattatt cagtaaggca agtattttaa aagatcatct
     2281 atctgaagtt atacatagta atttagtgtg aacgtaaata gttatatcca gttttggttc
     2341 ttacaagaca gaaaagacca acaataaagc agtatgtgag tgcacatata ggtgtgtcag
     2401 aaaatttaaa gctgtgagaa gagttttgat taacagacag gtaagagaat acttatcatc
     2461 tgtttatctg gaaagataga gccatagatt tctatggtag catagagcca ccagtcacat
     2521 ccctcaatgc tgaatttgca gtttatcctc agttttatat ctttaactgt aaaggaatgg
     2581 tactaaaggt catctgtcag aaatttcagt gacttggtaa gttttgaaaa gttgaattaa
     2641 tcagataaat aacacaaatc aatgtatttg gcatattttt atatggaatt ggaggcaaat
     2701 ccctacctag gaatagaaat ataaaaaatt cagagtattg gggggaaagg ttagaattcc
     2761 ctactgttta cagatcattt gggggaactt ttgatgatag caaaattttt gttgtttttt
     2821 aaatattcaa tttcgactag aaaatagttt aaatagtatt tacatttttt ctgtactagt
     2881 gttcttactg aattgatagt attacaattt atatatttca aggtaagtat atatagcttc
     2941 aaatttagtt catatttgaa acattaaaat atctgatctg atatttgttt gttaaataag
     3001 tacatttata cttagtacca aataactagt aaccagtatg tttattataa agttgttttc
     3061 atggaagagt gactaggtag aaatttcaaa tgtaactctc atgaaattaa cctagctgaa
     3121 gggtagtggt gcacgtctgt aatcccagca ctgaggaggg agagaacttg gtttgtaaac
     3181 tcagatttgc ctaggctaca tagtgagacc ttactaagaa agaaaggggg atcacctaca
     3241 agattctttt tctggagatt catttttgag ttatgtaaat ttttattttt aaaaataaga
     3301 acttaaatgg atattaaagt ttaatattca aagcatgaac aatgtaattg atacctgacc
     3361 ttgatacttt atgtggatcg actttcctaa agtctgattt cccattatta ttcactttgc
     3421 tttaggtgta ttacctgtac ctaaagataa aacactgtta ttttaaaagt aggcagaact
     3481 ctaaaattca ttatctttac atctatatcc tagtcaacat aaagtttatt atagccctat
     3541 tgaaagcaaa gttcatatat aattacacgt atgattgtta ataggaactg cttttctttt
     3601 ttaaaagaaa gaactgaaga tatctggtgc cagtatttat agcagcagac gactaaacct
     3661 gaatatatta tactaagttt aatacaactc tagtcacttc aaaatctagg ttctcttagt
     3721 ctgtgcatac ttaacaggaa caagatcaaa ttagtatgta gtttaggact gaattacagg
     3781 tttcgttatc tgtgttatag aaactgtttc aagaacaggt tttcatcttt caataatgat
     3841 tatggtttat tactaaatat tcactcacag aggaatattc tcttggagac attctttttt
     3901 tatttggatt gctaaggaga aatgctgtta aggaacaaac tagtcaattt ctgttgtgtg
     3961 agggcaagga gagaagagca gaggatctga tggttactat gtaatcagga acacataccg
     4021 tgacatgtgt ttctgtcact ccactccacc aggcatagcg gcagacacct ttagtttcag
     4081 tggatctctg tgagctccag ggtagcctgg ccgacacagt gagatcagga cagccagagc
     4141 tacatagtga gacccaggaa gaaagaaaaa aaacatgttt ctgtcacttc attctgtttg
     4201 aataggtctt ctgttaatat tttttatcat gagaatagaa agttacatat attcttccca
     4261 caaacaaaaa gaaaacagaa aactgaacac ttaaatccct aattgtatat tcttgcattt
     4321 ttttaggtag aaactggaac tattaatatt tttgtgtatt taaataagta gttcttaaag
     4381 atggtatcta ataagtttaa aaattcattt gtcttctaaa ctcatgtgta gtcacagcgt
     4441 gtcagtattg gccaaaggtg cttagcatca gtattcgaaa actatgttta catatttaaa
     4501 tgtttaattc tttacaaatg taccagatct taaacacaag tgtataaaaa tttcagtctc
     4561 tgtatttggc attcacttaa caactccaca gcaaactttg atagtaccct ttggttcatg
     4621 tatgacaaga tggagtagga gctgaggggg agctggacat ttaaaataag cagttaggaa
     4681 ttcataatca tagcctggat tgtttctttg tagttttctt gttcaaaacc tccaagtaaa
     4741 ctttgtatat acaccaggaa attatcgatg aaccaccaca ggagactttc cccccagtag
     4801 taattttcta tgtaagcagc caatgtactt aaaaagcttt aacatcttat gcaaagtaaa
     4861 tgtttcctaa ccaccacaga agtgatagga aacatgaact ctgggtccgg tattgaagtt
     4921 tttaatctta gccccagctt gtgcttcatc ttgtttctat cctgtcaaac tatatatgta
     4981 atcatgtggg tatgagacag tgtttacttt ataccgggtt tgtaaaaaga tttcaaaatg
     5041 tgtatgtata tattgtaact tgatgtacag tgttcttatt ataatgtaat tttttattaa
     5101 aaattctgtt ttttctta
//
LOCUS       NM_001437674            2427 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 2, mRNA.
ACCESSION   NM_001437674 XM_063267198
VERSION     NM_001437674.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_063267198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.48892.1,
                                           SRR26643299.39360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000009.1  66815013-66815101
            90-139              JAXUCZ010000009.1  66839657-66839706
            140-224             JAXUCZ010000009.1  66873112-66873196
            225-285             JAXUCZ010000009.1  66898226-66898286
            286-394             JAXUCZ010000009.1  66921419-66921527
            395-444             JAXUCZ010000009.1  66924616-66924665
            445-691             JAXUCZ010000009.1  66927640-66927886
            692-898             JAXUCZ010000009.1  66942416-66942622
            899-1034            JAXUCZ010000009.1  66943912-66944047
            1035-1093           JAXUCZ010000009.1  66965594-66965652
            1094-1203           JAXUCZ010000009.1  66979059-66979168
            1204-1306           JAXUCZ010000009.1  66981573-66981675
            1307-1527           JAXUCZ010000009.1  66984115-66984335
            1528-2427           JAXUCZ010000009.1  66987185-66988084
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2427
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..89
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            90..139
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            140..224
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             187..1920
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 2"
                     /protein_id="NP_001424603.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITEGSRLLQQKMSLDGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVK
                     SNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAA
                     FAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAEL
                     RAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLP
                     LLNTHAVASGKQGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQNGP
                     SNQRRRFNPQYHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAKN
                     QEAPLGTKAPEAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEAT
                     VLSVPAVTLVA"
     misc_feature    421..1350
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    421..1350
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            225..285
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            286..394
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            395..444
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            445..691
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            692..898
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1034
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1093
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1203
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1306
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1527
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2427
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgctctc cctccgctcg ccctccgcgc cgcaggggcc gccagcgctg cgccccggcc
       61 cgggacagag cggccgcact cgcaccgagg agactccaga agccaggctg ctttcgggaa
      121 caactctgtg gattcccagg tcctgtggtc agagctgaag gccccggtta gtcccgctgc
      181 aagtacatgg ctggaacaca ggaaaccgga gcttcaacga gcaaggctta tacccctaga
      241 aggaagatgg ctgaactcaa cactcatgtg aatgtcaaag agaagatcta cgcagttaga
      301 tcagttgttc cgaacaaaag caataatgaa attgtcctgg tgctccaaca gtttgatttt
      361 aatgtggata aagccgtgca agcctttgtg gacggcagtg ctattcaggt tcttaaagaa
      421 tggagcatga cggggaaaaa gaagaataac aaaagaaaaa gaagcaaatc caagcagcat
      481 caaggcaaca aagatgctaa ggacaagggg gagaggccgg aggtggggcc cctgcagccc
      541 caggcaccac tggtacaaaa tggtcacatg aatggctgtg aaaaggacag ctcatcccct
      601 gactctgcca gagaaaaact ggccctcaca ccacgtgaga aaaagatctc aatactggag
      661 gaaccaccaa gggctcagcg tgggatcaca gaaggcagca gactactgca gcagaaaatg
      721 tccttagatg ggaaccccaa agctattcat ggaccatcag agaggtcaga tggcctacag
      781 tggtcagctg ggcagccttg taacccaagc aagcctaagg caaaaacatc tcctgttaag
      841 tccaatgccc ctgcagctca tcttgaaata aagccagatg agctggcaaa gaaaagaggt
      901 ccaaatattg agaaatcggt gaaggatctg cagcgctgca ctgtttctct gacgagatac
      961 cgagtcatga tcaaggaaga ggtggacagt tctgtgaaga agatcaaagc agcttttgct
     1021 gagctacaca actgcatcat tgacaaagaa gtttcactga tggcagagat ggataaagtt
     1081 aaagaagaag ccatggacat cctgactgcc cgtcagaaga aggcagagga gctgaagcga
     1141 ctgactgatc tagccagtca aatggcagag atgcagctgg ccgaactcag agctgaaatt
     1201 aagcactttg tcagcgaacg caaatatgat gaagagctag ggaaagccgc ccgcttctcc
     1261 tgcgacattg aacagctgaa agcccaaatc ctgatctgcg gagaaatcac acatccaaag
     1321 aacaactatt cctcaagaac tccctgcagc tccctgttgc ctctgctgaa cactcatgcg
     1381 gtagcttccg ggaagcaggg gaatttttcc cggaagtcat ccggtcacaa caagcccaat
     1441 gaggggaaag cagcgaaccc caaaatggtg agcggtcttc ccagcactgc cgatgcatgt
     1501 cagcagacca tgcctactaa caagcagaat ggaccttcca accaaagacg aagatttaat
     1561 ccacagtatc acaacaggct aaatggtcca gccaagtcac agggcagtgg taatgaagct
     1621 gatcccatgg tgaagagcaa caaccgacat gaacacagaa gacagccaca taatggtttt
     1681 cgtcccaaaa acaaaggtgg tgccaaaaac caagaggccc ccttggggac aaaggcccca
     1741 gaggccccac cacattctga aaaggcccgt cgaaggcagc acgctgcaga caacttagag
     1801 accaggcctt tccggggtaa tgttggtagg gtttcacagt gcaatctttg tcccactaga
     1861 atagaagttt ccacagaggc cacggttctc tcagtcccag ctgtgacgct ggtggcctga
     1921 gctgggaagg aagagagcag gttttgcctg gttttggttc cctgcccaag gtgctgaccc
     1981 aattcgctgc caaaagagag tcaatcagaa tatacaaacc tgtatgtttg tgtcgttctc
     2041 tcgcaatcat ttttactaat cctagtactc tgctctagct tgcttcataa ctcccatggc
     2101 tttgcttgat ctgttgtcgc ttctcctcat caagactttg catcatgtta gccagccagt
     2161 atttacccat tgttaggaaa atcgagatgt ggctgaagat cagaggctca gttagcaacc
     2221 tacgttgtag ctgtgatgtc gacccattgg ttgtctttag agagttaatg ttgaaacaag
     2281 aaattcttga tcagacaaac gtgatctgct gaagacacat gtgcttttgt agaatttaac
     2341 atctggtgtt tttctgaaat attatataaa tatatatata aacatatatt gctttatttg
     2401 aaacaaatta aaatatgctg catttga
//
LOCUS       NM_001437677            2428 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 6, mRNA.
ACCESSION   NM_001437677 XM_017596460
VERSION     NM_001437677.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_017596460.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1576754.1,
                                           SRR26643295.35384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000009.1  66814482-66814568
            88-137              JAXUCZ010000009.1  66839657-66839706
            138-222             JAXUCZ010000009.1  66873112-66873196
            223-283             JAXUCZ010000009.1  66898226-66898286
            284-392             JAXUCZ010000009.1  66921419-66921527
            393-442             JAXUCZ010000009.1  66924616-66924665
            443-689             JAXUCZ010000009.1  66927640-66927886
            690-896             JAXUCZ010000009.1  66942416-66942622
            897-1032            JAXUCZ010000009.1  66943912-66944047
            1033-1091           JAXUCZ010000009.1  66965594-66965652
            1092-1201           JAXUCZ010000009.1  66979059-66979168
            1202-1304           JAXUCZ010000009.1  66981573-66981675
            1305-1525           JAXUCZ010000009.1  66984115-66984335
            1526-2428           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2428
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..87
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            88..137
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            138..222
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             185..1921
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 1 is encoded by transcript variant 6;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 1"
                     /protein_id="NP_001424606.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITEGSRLLQQKMSLDGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVK
                     SNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAA
                     FAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAEL
                     RAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLP
                     LLNTHAVASGKQGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNG
                     PSNQRRRFNPQYHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAK
                     NQEAPLGTKAPEAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEA
                     TVLSVPAVTLVA"
     misc_feature    419..1348
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    419..1348
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            223..283
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            284..392
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            393..442
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            443..689
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            690..896
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1032
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1091
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1201
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1304
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1525
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..2428
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactcccaga aagcattact accttctgtc gggagaagca tcttgccttt gcagacggta
       61 ctggggcagc aaagttcgtt ttcctcggag actccagaag ccaggctgct ttcgggaaca
      121 actctgtgga ttcccaggtc ctgtggtcag agctgaaggc cccggttagt cccgctgcaa
      181 gtacatggct ggaacacagg aaaccggagc ttcaacgagc aaggcttata cccctagaag
      241 gaagatggct gaactcaaca ctcatgtgaa tgtcaaagag aagatctacg cagttagatc
      301 agttgttccg aacaaaagca ataatgaaat tgtcctggtg ctccaacagt ttgattttaa
      361 tgtggataaa gccgtgcaag cctttgtgga cggcagtgct attcaggttc ttaaagaatg
      421 gagcatgacg gggaaaaaga agaataacaa aagaaaaaga agcaaatcca agcagcatca
      481 aggcaacaaa gatgctaagg acaaggggga gaggccggag gtggggcccc tgcagcccca
      541 ggcaccactg gtacaaaatg gtcacatgaa tggctgtgaa aaggacagct catcccctga
      601 ctctgccaga gaaaaactgg ccctcacacc acgtgagaaa aagatctcaa tactggagga
      661 accaccaagg gctcagcgtg ggatcacaga aggcagcaga ctactgcagc agaaaatgtc
      721 cttagatggg aaccccaaag ctattcatgg accatcagag aggtcagatg gcctacagtg
      781 gtcagctggg cagccttgta acccaagcaa gcctaaggca aaaacatctc ctgttaagtc
      841 caatgcccct gcagctcatc ttgaaataaa gccagatgag ctggcaaaga aaagaggtcc
      901 aaatattgag aaatcggtga aggatctgca gcgctgcact gtttctctga cgagataccg
      961 agtcatgatc aaggaagagg tggacagttc tgtgaagaag atcaaagcag cttttgctga
     1021 gctacacaac tgcatcattg acaaagaagt ttcactgatg gcagagatgg ataaagttaa
     1081 agaagaagcc atggacatcc tgactgcccg tcagaagaag gcagaggagc tgaagcgact
     1141 gactgatcta gccagtcaaa tggcagagat gcagctggcc gaactcagag ctgaaattaa
     1201 gcactttgtc agcgaacgca aatatgatga agagctaggg aaagccgccc gcttctcctg
     1261 cgacattgaa cagctgaaag cccaaatcct gatctgcgga gaaatcacac atccaaagaa
     1321 caactattcc tcaagaactc cctgcagctc cctgttgcct ctgctgaaca ctcatgcggt
     1381 agcttccggg aagcagggga atttttcccg gaagtcatcc ggtcacaaca agcccaatga
     1441 ggggaaagca gcgaacccca aaatggtgag cggtcttccc agcactgccg atgcatgtca
     1501 gcagaccatg cctactaaca agcagcagaa tggaccttcc aaccaaagac gaagatttaa
     1561 tccacagtat cacaacaggc taaatggtcc agccaagtca cagggcagtg gtaatgaagc
     1621 tgatcccatg gtgaagagca acaaccgaca tgaacacaga agacagccac ataatggttt
     1681 tcgtcccaaa aacaaaggtg gtgccaaaaa ccaagaggcc cccttgggga caaaggcccc
     1741 agaggcccca ccacattctg aaaaggcccg tcgaaggcag cacgctgcag acaacttaga
     1801 gaccaggcct ttccggggta atgttggtag ggtttcacag tgcaatcttt gtcccactag
     1861 aatagaagtt tccacagagg ccacggttct ctcagtccca gctgtgacgc tggtggcctg
     1921 agctgggaag gaagagagca ggttttgcct ggttttggtt ccctgcccaa ggtgctgacc
     1981 caattcgctg ccaaaagaga gtcaatcaga atatacaaac ctgtatgttt gtgtcgttct
     2041 ctcgcaatca tttttactaa tcctagtact ctgctctagc ttgcttcata actcccatgg
     2101 ctttgcttga tctgttgtcg cttctcctca tcaagacttt gcatcatgtt agccagccag
     2161 tatttaccca ttgttaggaa aatcgagatg tggctgaaga tcagaggctc agttagcaac
     2221 ctacgttgta gctgtgatgt cgacccattg gttgtcttta gagagttaat gttgaaacaa
     2281 gaaattcttg atcagacaaa cgtgatctgc tgaagacaca tgtgcttttg tagaatttaa
     2341 catctggtgt ttttctgaaa tattatataa atatatatat aaacatatat tgctttattt
     2401 gaaacaaatt aaaatatgct gcatttga
//
LOCUS       NM_001014102            2291 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 4, mRNA.
ACCESSION   NM_001014102 XM_237177
VERSION     NM_001014102.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced NM_001014102.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085874.1, SRR26643291.25585.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000009.1  66889337-66889421
            86-146              JAXUCZ010000009.1  66898226-66898286
            147-255             JAXUCZ010000009.1  66921419-66921527
            256-305             JAXUCZ010000009.1  66924616-66924665
            306-552             JAXUCZ010000009.1  66927640-66927886
            553-759             JAXUCZ010000009.1  66942416-66942622
            760-895             JAXUCZ010000009.1  66943912-66944047
            896-954             JAXUCZ010000009.1  66965594-66965652
            955-1064            JAXUCZ010000009.1  66979059-66979168
            1065-1167           JAXUCZ010000009.1  66981573-66981675
            1168-1388           JAXUCZ010000009.1  66984115-66984335
            1389-2291           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2291
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..85
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    81..83
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     exon            86..146
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1784
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 4 is encoded by transcript variant 4;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 4"
                     /protein_id="NP_001014124.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAELNTHVNVKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAV
                     QAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNKDAKDKGERPEVGPLQPQAPL
                     VQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEPPRAQRGITEGSRLLQQKMSL
                     DGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVKSNAPAAHLEIKPDELAKKRG
                     PNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMD
                     KVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSERKYDEELGKA
                     ARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLPLLNTHAVASGKQGNFSRKSS
                     GHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNGPSNQRRRFNPQYHNRLNGPA
                     KSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAKNQEAPLGTKAPEAPPHSEKA
                     RRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEATVLSVPAVTLVA"
     misc_feature    111..113
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ6; propagated from
                     UniProtKB/Swiss-Prot (Q5U2T3.1); acetylation site"
     misc_feature    282..1211
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    282..1211
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    294..551
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    465..467
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ6; propagated from
                     UniProtKB/Swiss-Prot (Q5U2T3.1); phosphorylation site"
     misc_feature    588..713
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1254..1649
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1470..1472
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ6; propagated from
                     UniProtKB/Swiss-Prot (Q5U2T3.1); phosphorylation site"
     exon            147..255
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            256..305
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            306..552
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            553..759
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            760..895
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            896..954
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1064
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1167
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1388
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2291
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgttggg ctgctgagga ggaagcaagt agctggaaca gtctatgcct gacagcccga
       61 agcggaacac caagagacct tgagaggctt atacccctag aaggaagatg gctgaactca
      121 acactcatgt gaatgtcaaa gagaagatct acgcagttag atcagttgtt ccgaacaaaa
      181 gcaataatga aattgtcctg gtgctccaac agtttgattt taatgtggat aaagccgtgc
      241 aagcctttgt ggacggcagt gctattcagg ttcttaaaga atggagcatg acggggaaaa
      301 agaagaataa caaaagaaaa agaagcaaat ccaagcagca tcaaggcaac aaagatgcta
      361 aggacaaggg ggagaggccg gaggtggggc ccctgcagcc ccaggcacca ctggtacaaa
      421 atggtcacat gaatggctgt gaaaaggaca gctcatcccc tgactctgcc agagaaaaac
      481 tggccctcac accacgtgag aaaaagatct caatactgga ggaaccacca agggctcagc
      541 gtgggatcac agaaggcagc agactactgc agcagaaaat gtccttagat gggaacccca
      601 aagctattca tggaccatca gagaggtcag atggcctaca gtggtcagct gggcagcctt
      661 gtaacccaag caagcctaag gcaaaaacat ctcctgttaa gtccaatgcc cctgcagctc
      721 atcttgaaat aaagccagat gagctggcaa agaaaagagg tccaaatatt gagaaatcgg
      781 tgaaggatct gcagcgctgc actgtttctc tgacgagata ccgagtcatg atcaaggaag
      841 aggtggacag ttctgtgaag aagatcaaag cagcttttgc tgagctacac aactgcatca
      901 ttgacaaaga agtttcactg atggcagaga tggataaagt taaagaagaa gccatggaca
      961 tcctgactgc ccgtcagaag aaggcagagg agctgaagcg actgactgat ctagccagtc
     1021 aaatggcaga gatgcagctg gccgaactca gagctgaaat taagcacttt gtcagcgaac
     1081 gcaaatatga tgaagagcta gggaaagccg cccgcttctc ctgcgacatt gaacagctga
     1141 aagcccaaat cctgatctgc ggagaaatca cacatccaaa gaacaactat tcctcaagaa
     1201 ctccctgcag ctccctgttg cctctgctga acactcatgc ggtagcttcc gggaagcagg
     1261 ggaatttttc ccggaagtca tccggtcaca acaagcccaa tgaggggaaa gcagcgaacc
     1321 ccaaaatggt gagcggtctt cccagcactg ccgatgcatg tcagcagacc atgcctacta
     1381 acaagcagca gaatggacct tccaaccaaa gacgaagatt taatccacag tatcacaaca
     1441 ggctaaatgg tccagccaag tcacagggca gtggtaatga agctgatccc atggtgaaga
     1501 gcaacaaccg acatgaacac agaagacagc cacataatgg ttttcgtccc aaaaacaaag
     1561 gtggtgccaa aaaccaagag gcccccttgg ggacaaaggc cccagaggcc ccaccacatt
     1621 ctgaaaaggc ccgtcgaagg cagcacgctg cagacaactt agagaccagg cctttccggg
     1681 gtaatgttgg tagggtttca cagtgcaatc tttgtcccac tagaatagaa gtttccacag
     1741 aggccacggt tctctcagtc ccagctgtga cgctggtggc ctgagctggg aaggaagaga
     1801 gcaggttttg cctggttttg gttccctgcc caaggtgctg acccaattcg ctgccaaaag
     1861 agagtcaatc agaatataca aacctgtatg tttgtgtcgt tctctcgcaa tcatttttac
     1921 taatcctagt actctgctct agcttgcttc ataactccca tggctttgct tgatctgttg
     1981 tcgcttctcc tcatcaagac tttgcatcat gttagccagc cagtatttac ccattgttag
     2041 gaaaatcgag atgtggctga agatcagagg ctcagttagc aacctacgtt gtagctgtga
     2101 tgtcgaccca ttggttgtct ttagagagtt aatgttgaaa caagaaattc ttgatcagac
     2161 aaacgtgatc tgctgaagac acatgtgctt ttgtagaatt taacatctgg tgtttttctg
     2221 aaatattata taaatatata tataaacata tattgcttta tttgaaacaa attaaaatat
     2281 gctgcatttg a
//
LOCUS       NM_001191809           13448 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus INO80 complex subunit D (Ino80d), transcript
            variant 2, mRNA.
ACCESSION   NM_001191809 XM_006245031 XM_237220
VERSION     NM_001191809.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 13448)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Apr 8, 2025 this sequence version replaced
            XM_006245031.4, NM_001191809.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.757360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000009.1  72007085-72007245   c
            162-253             JAXUCZ010000009.1  71988716-71988807   c
            254-500             JAXUCZ010000009.1  71988364-71988610   c
            501-1231            JAXUCZ010000009.1  71980268-71980998   c
            1232-1340           JAXUCZ010000009.1  71974486-71974594   c
            1341-1565           JAXUCZ010000009.1  71969327-71969551   c
            1566-1675           JAXUCZ010000009.1  71963374-71963483   c
            1676-1809           JAXUCZ010000009.1  71960532-71960665   c
            1810-2027           JAXUCZ010000009.1  71955044-71955261   c
            2028-2185           JAXUCZ010000009.1  71954146-71954303   c
            2186-13448          JAXUCZ010000009.1  71940941-71952203   c
FEATURES             Location/Qualifiers
     source          1..13448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..13448
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="INO80 complex subunit D"
                     /db_xref="GeneID:316440"
                     /db_xref="RGD:1304808"
     exon            1..161
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            162..253
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            254..500
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    271..273
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="upstream in-frame stop codon"
     CDS             283..3348
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /codon_start=1
                     /product="INO80 complex subunit D"
                     /protein_id="NP_001178738.1"
                     /db_xref="GeneID:316440"
                     /db_xref="RGD:1304808"
                     /translation="MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDK
                     TAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPVDEVKV
                     RHQMDAMAFSLTVPTLALKMPNGLDSMSLSPPGARVPLHYLETELEDPFAFNEEDDDL
                     KKGVTVRKKLQSKLAQNRQRQRETEILKVRQEHFSTPPTPPQQHAHLSPLPTSLKPPA
                     PPQGSVCKSPQPQSTSLPMQGVAPTTHSIAQTRQASHKRPLPLLPSSRAPVSDTPRTD
                     RILMKATAFSPHFSCISRLQRLVKLCTQKHQLDADLFPHLGLDWSEESGEELEDSDQA
                     SPYQVAWSVRETLRQERHTSDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAESRQKK
                     CRHTFRKALLQAASKEPECTGQLIQELRRAACSRDSLSQTKLKEVEPAACSGTVKGEQ
                     CTNQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKK
                     MDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNL
                     SMPTSVSLPVQASQIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFADVLPRLP
                     DDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLSQSDGVPVQGLSD
                     RGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVHDSFSSLELDENLLHSATLSNPP
                     TPLAGQIQGQFSAPASVGLTSATLLSQSALGERAFPGQFHGLHDGSHASQRPHPAQLL
                     SKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTSYSGDNMAATFSA
                     EMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAFSNLLGADGHLLSTSLST
                     PPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAA
                     FGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASPPFPTPN"
     misc_feature    334..519
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    334..519
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    <790..>1137
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <790..>1137
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    1606..1800
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    1606..1800
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     exon            501..1231
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1340
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1565
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1675
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1809
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2027
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2185
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..13448
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtcaggt gcagccgcgg cccggaaagt ttccttttag gcccgaattg ggggctgcct
       61 tctctctggg gagccccggt cctagcgccc ggggcccccg agggcgtggg ggagagcact
      121 cggctggctc gaaactcttt gccagttcct gtccgttcaa gacaatctgc ttcttcttga
      181 ttgatcagca ttccaaactg tggtacccct gggctctctt cacattgctg tggtgcagaa
      241 gatttaaaat cagctgatgt tcacaaggaa tagagtcacg tgatgtatga agggaaacat
      301 atacacttct ctgaggttga caataagccc ttgtgctcat atagccccaa actgtgcaag
      361 cagcggcgac tcaacggcta cgctttctgt atcagacacg ttctggaaga caagactgcc
      421 cccttcaagc aatgtgaata tgtggccaag tataacagcc agcgctgcac caaccccatt
      481 cccaagtcag aggatcgcag gtactgcaac agccacttgc aggtactcgg ctttatcccg
      541 aaaaaagaga ggaagaaaaa gaatgacccg gtagatgagg tgaaggtcag gcaccagatg
      601 gacgccatgg catttagcct gacggtacct accctggcct tgaagatgcc caatggactg
      661 gatagcatgt ccctctctcc acctggggca agggttcctc tccactacct ggaaactgag
      721 ttggaagacc cctttgcttt caatgaggaa gacgatgacc taaagaaagg ggtgacggtg
      781 agaaaaaagt tgcagagcaa attggctcag aaccggcaac gccagagaga gacagagatt
      841 ttaaaagttc ggcaagagca ctttagcacc cctcccacac ctccacagca gcacgcccac
      901 ctgtcacctc tacctacttc tttaaaacct ccagcgccac cacagggctc agtctgcaag
      961 tcacctcagc ctcagagcac cagcctacca atgcagggag tggcccccac cacacactct
     1021 atagcacaaa caaggcaggc ctctcacaag aggcctctgc ccctccttcc ctccagtcga
     1081 gctcccgtct cagacacccc caggactgac cgaatcctca tgaaagccac cgccttctct
     1141 ccacacttct cttgtataag ccgactgcag agactggtga aactgtgtac ccaaaagcat
     1201 cagctggacg cggatctgtt tcctcactta gggctggact ggtctgagga gagcggagag
     1261 gagctggagg attcagatca ggcttcacca tatcaggtcg catggtccgt ccgagaaacc
     1321 ctcagacagg aaagacacac gtcagatgac gacgatgcgg agagcaggag ctccagggtg
     1381 acccaacttt gcacttactt tcagcagaaa tacaagcacc tctgccgcct ggagcgtgca
     1441 gagtcgcgac aaaagaaatg ccggcatacg tttaggaagg cgctgctgca ggcagccagt
     1501 aaggagcccg aatgtactgg tcagctgata caagaacttc ggagagctgc gtgtagccga
     1561 gacagcctca gccagaccaa gttgaaggag gtggagccag cagcttgcag tggaacagtg
     1621 aagggtgaac agtgcacaaa ccaggccctg cccttcacca ggcattgttt ccagcacatc
     1681 ctcttgaacc gttctcagca gctgttctcc agctgcactg ccaagtttgc agacggacag
     1741 cagtgctctg tgccagtgtt tgacattaca caccagacgc ccctgtgcga agaacatgcc
     1801 aaaaagatgg ataatttcct gagaggagat aactcccgta aagttcagca ccagcaacag
     1861 aggaaaccta ggaaaaaaac aaagccccct gcacttacca aaaaacacaa gaagaagaga
     1921 cggcgtggac ctcgtcgacc ccagaagccc atccctcctg cagtgcccca agggaatctc
     1981 agcatgccca ccagcgtctc actgccagtg caggcctccc agatccgaag cccttccacg
     2041 ccagagctga gtgctgacga gttgccggat gacattgcca atgagatcac tgacattccg
     2101 cacgacttgg aattgaacca ggaagacttt gcagatgtcc tgccgcggct gccggatgat
     2161 ttacaagact ttgatttttt tgaaggaaag aatggagacc tcctcccgac cactgaagaa
     2221 gctgaagagc ttgagcgggc cttgcaagct gtaacttctc tcgagtgcct gagtacaatt
     2281 ggggtacttt cccagtcaga cggtgtgcca gtccagggct tgtcagatag agggatgggg
     2341 gtgttctcca cgggtaccga tgcttcggga atccagtcct tgagtcgaga agtaaacacg
     2401 gatctagggg agctactgaa cggacgtata gtacacgata gcttttctag tctagagctg
     2461 gacgagaacc tactccattc tgctactctg tccaacccac ctacacccct ggcagggcag
     2521 atccaggggc agttctctgc cccagccagc gttggcctta cttctgccac tctgctcagc
     2581 cagagtgcac ttggggagag agccttccca ggacagtttc atggacttca tgatggcagc
     2641 catgcctctc agaggccaca tcctgcccag ctgctgagca aggcagacga ccttatcacc
     2701 tcacgacagc aatacagcag tgatcattca cactcctcac cccatggaag ccattatgat
     2761 agcgagcacg tgccgtcgcc ctacagtgac catatcacct ctccccacac atcttactct
     2821 ggtgataata tggcagctac cttttcagca gagatgccca tcatggccca gcacttgctc
     2881 cccacccagc ttgaggtgcc acttggagga gtggtcaacc ccagaactca ctggggcaat
     2941 ctccccgtca accttggcga tccctctgca tttagcaacc tccttggcgc ggatggacac
     3001 cttctttcca cttccctctc cacgccaccc accacatcca actcagagac cacacagcct
     3061 gccttcgcca ccgttacccc aagcagttcc agtgtgcttc cggggttacc acagaccagc
     3121 ttcagtggca tggggccttc tgctgaacta atggcctcca cctctcccaa gcagcaactc
     3181 ccacagttca gcgcagcctt cggccaccag ctgagttctc acagtggcat tcctaaggac
     3241 ctgcagccca gccacagctc catagcccct cctacaggct tcacagtaac aggtgccacc
     3301 gctacaagta ccaataatgc atctcccccc ttccccaccc ccaactgagc gagtctgtgt
     3361 gcttgccggc aggtggaacc cggtgttttc tatctttgtt tcctcttttg cacccctctc
     3421 tccttttcct acagaagatt taaaaatgac agtggggatt agagggacgc cccttcccgg
     3481 ttcaacaggt ggccgtgcag tggaccttgc gtcagtgttc gcgcgtgctc cctagcactg
     3541 gtgctcattc cctcctggcg gtccgctcag cctggcgggt cactcggcct ggcaggcttt
     3601 ttggtggctc agcacagtga ctgggtagga ttgattattt tattttttat ttttattttt
     3661 atttgttttt atttcagcaa gtcctagaag tggaagatac ctcagattac cagtgccctt
     3721 tactgtctcc tactgttgag ataatgcttc ccattctcta gccaggtttt acataggttg
     3781 ttctggatgt tctgttgaga tcctgtgtag taggtggtgt gcggacacaa atcaaagctc
     3841 tgacttagca ccaactgcca gacaccacag ggaggccagg atgccattcc taattatgat
     3901 acattagctg aaaagaacat ggtctcttaa ctgcctgtgc ctgcttgttc attcgtcctg
     3961 tgtgtgtgct gtgcagtgca gtagctgtcg cttgtggctt gtctctcctc actcccagaa
     4021 taagcatagg cccttccccc tcctcctgtc tcatgccttg caagattcgt ccttccttcc
     4081 tactgagttg ctaaagcatc ctgaacagag aggggtggtc tcagagtgat agcgccttgc
     4141 taaaatcagc ctgtgaggaa aggagcccag aggcggagct cacatcagtc atggggagtg
     4201 tcgtgacccc ccacctctct tctatcatgt gcatttgttt cagattcccc actcatggaa
     4261 cacatttgta agtagtaatg aaaaaaatgt tttggtgtgc aaaagcaggc tacaccagag
     4321 agattcgaaa gatgacatct cggcctgttt ggtccatcat tggctcctag tttttacatg
     4381 tttacagttg tgattctttg gtgagatttg tgaactgtgg aggacacctg tagaaccgtg
     4441 taccagttgt gaagtgatgt gtaatatcag aaggacacac attttaacag ttctgtcaaa
     4501 gcagaatttg gaaattagac ataatttgac tcaccttagg tacttttaaa ataatttaag
     4561 taaaattgga aaattttttt aacgtaccaa ggctttaggg taaaaaatct tgttgggtag
     4621 tgcagtaagt tggtgactgt gaagtgatgt gagggtttcc tcttgcctgc cttcccctcc
     4681 cagcggggtg gagcttcatt ttctgctctg ctctgctctg ctgatggctc cctgcccctt
     4741 cagatatcgt caggtgtcta catctgagct ccacctgatt tacatgcaga cactcttaaa
     4801 agtgaggcag catgtctcta aatgacgtgt gtggtacagc aatcctttag tcagggactg
     4861 tctgatccta attccttcct gcgagtttaa ggttgggacg tattttccta cttcttatgt
     4921 gtgtgttcct cgtgctactt ctgaccaggt cttcctgttg aaggccttgc aaaggaatga
     4981 tggtggttac caggcattat gcagacacca cgtgcctgag ctttggagag aaagtgtcac
     5041 atgaccagat gaaatcatga tctgacctat tttgtattta ctgaagttgg ggaggcaaat
     5101 atgtttgtaa tatgtttcct ttttttcctt aaaaataatg ttagttaatt ggaacatttg
     5161 tttttaatag ctttgccttt ttttgcaaat tgagaaaatc ctaaattata aattatgtca
     5221 caaagcaaaa ttatatttgg tatcaccatg aacttctctc ctgaattgtg agaacagctt
     5281 tttgactgtt tgatctgtga gcctatgtca gtagcttttt tattttagta tgctgtaata
     5341 gagtgagagt gagtggttac ctcacctcaa aagtgtcatt tcgtttgtta ggctgttctc
     5401 acatccccac tagaatcatt ttaggtaact gaattcccag aaaatgcatt ttgtctccag
     5461 tgtgcatcga ctgaagactg tagcagagcc acatggccgt ctccttatcg gctcctcttt
     5521 gccagggaga gggaagtcgt gagtagtcaa tttggactgc cactgtctgt ctgtctctgt
     5581 gttagctgct gaaactcgtt tagttgtcaa actgagtttg caggaggttg caccttttat
     5641 tgtttgcagt tttctgttta tgtgcattta aaagcccttc ttcgctttcg agtaaggagg
     5701 cttgaagtga tcaggaatgt tgccagttac agcttcacgc caaaaatgtt gagcaagctc
     5761 ccttctgttc agatgcccat gatggttgct gaagggaggg cagtcttgga aatactgata
     5821 atggactgaa taattagcaa aagcacactt tccttccgtc tcagaacgaa catccaagcc
     5881 tgtaatttgc ttttctcttg gtttttttgt gagctccctg ttagaggaat atctgtttct
     5941 aagcccagag gtgtccactt tgtcacccct ctagctgttg aagcaattct agtctcttag
     6001 tagtaggtgg gtattaatat gcaaagaaag ttcagcatct tttgtaatgc ttatatgaaa
     6061 acgtagcact tatggtaagg caatactgga atcaaaaaca aaccctgcac aggccctaat
     6121 gggatagaag ctagtattag tgtagtgttg agtacatgag ggacagtaac aaagaaggct
     6181 cactgtgtct ctgcgggttc tgggaccatt tataaaggcc agttcattgt gttactgtga
     6241 cttaacttgt gaagttgctg ccgttgatga ctgactatgt gctctgagaa tatgaatgtc
     6301 agcaactgta atctctggta cctgaaggga agatgggctt tctctccttt aactgctaat
     6361 gttattttag tgaaagtact caagacattg tttttttctt ctgtaaaaat ggcttagcaa
     6421 tgttcatacc tgggtaggtt atacagctag tgaacaattc aggatagtaa atgacagtta
     6481 gaggaagccc accaagtaac agactctgca atggacacat cttgtactta tcatcccata
     6541 gttgaaagca gagattttct ctagtgagcc tactgtgtga ggtattcctg cttataaatg
     6601 acagcagttc cctgttggca ggtaatgtga tctaatgtcc ctctgtgaga agattttggt
     6661 ttgatgagaa gcagatagtt attagagatg gagttggaaa gtgattattt tatattgcca
     6721 aataactgtt tataagatga atcttttaaa gtaaaaccag actgtcacct gaaggttagg
     6781 gaatcatccc ttctgagagt cacactaaaa actcttccaa agttcattct cagtccatcc
     6841 atgctcccgg tccacatggc aaagtcagtt ctgtgtttag gagggagcca tgttcaggca
     6901 tcctgaatat ttagtttctt ttacacgaaa gaatagcttt ctgttggctt cttgcattgc
     6961 ttgttataaa taaggcatta gagatgagtc actcacacag aggtgaaccc cttactgtgt
     7021 gttccttgac cctgccccgc tgtgcgctgt gcgctggcat cctggtcagc ggcgggtggc
     7081 gtgtgggcgt cctcttcagt gcctgtctga aagcattgcc ttctctagtg cagttctcag
     7141 catggctgtg cgttgtttca cactgcagag tgggagtgag gatattaaca ctcaactcct
     7201 taataggttt ggaattcatt atacttttaa aagtatttac tttttagtct cctttttaga
     7261 cttaaaaaga ttaagttcta tactttatct gacatgtgta ggataatcta ataaatggtt
     7321 tgttgaatgg tcaacacaac tctgcagtat aatgaggaga tttagaaaca tctttgaaag
     7381 ataatttaat tggagtgagt gttctctcgt attttttttt ctttactgct acccacattg
     7441 ttctatggat tcttcatgtc aagagtactt catgggagac agtcattcat gaaaagacat
     7501 atttttcccc ctttcaacaa ataaaaaaat aactgacttc ttccctgaaa ttcagaaaaa
     7561 agaaaaatga cttcttaata ctttggcttc tttagccttc ccatgttatt atatttgtgg
     7621 gacccaaaat cacagtttaa ttaaagtagt atttacatga gatctttcaa aatgtttata
     7681 atacaatgcg gtctctgaga aaagcagagg cagatgcctg ttgagccttt ccactggcca
     7741 gtgagtgagt gagtcaggaa ggcctgtgtg ggattagccc tgcctctcgt aaggcccagt
     7801 gtgtggatgc gtggttgtga gtaactgtag gaacctgtgg ttctttactc cagtgtttgt
     7861 gcttggctgg cttcccctct tgcactgtgg tgtgaagcaa gtagaagaga tgtggcattt
     7921 cagagatttg ttgtgacttt atttaccctg tgtttctgag tatcaggaat gttttgagtg
     7981 ctttgaagag cagatcaaca tggtctttgg ctgacctaaa gctagtctag aaagcagtct
     8041 tctgaggtga aagctgctcg actcttgatg gctggcgggc agcatgtttt cttctcttcc
     8101 tccctccctc tgccttttgc acgctcttcc ccgtgctgca gtgtgcgtgt gccgcactcg
     8161 tcttggccca agagtggtag gattttcatt cgttggttct cattgttctt atgtgtttgt
     8221 ttgtttgctt tttaagctgg ggaccactga cctaagctct atatgcaccc caagttcccc
     8281 atggagaacg cttcaacatg caggacggaa ggcaccagtt acagctcaag gccacaccgt
     8341 cgcttttcct tggggactta ggctgatttg cttggaactg accccagcct gtgtcatgta
     8401 gtccaggcgg ctccagcggg ttagtgctga ctcgggggag agcttgacac ctgccgacag
     8461 tgtgtgcctc tgctccaaag ggttgaatca gttcttctca acggtgatag ctcttctcac
     8521 tgtctagtgt tgagtatgtc tcagggattc cttgcggaaa ttagggcagt ttttaaaata
     8581 aggaaatagt tttaaaggaa actaaaggtg actcctcact gatgagagct ccagaaagag
     8641 aaagcgtttg gtttcacagc ccgtggtgtc tcgccgagga cttcctttct acttcaggct
     8701 ctcatctcag cttcagctta cagaatcctt tcccatcatg cacagcttta aaacttttat
     8761 ttaaaacttc cttccccaat gagctttcag aatacttatt gtagatttta agagaaaagg
     8821 tatattaatt tatgctatta acatcacctc ataaattata agttttatac taaagctgta
     8881 ttgagtgtaa tgaattatgt tgcctatgtg ttttaatagc ttaaaattat atatgagctt
     8941 ctttttattt ttatttttat tttttgacaa aacaaactag tgacgcacct tcttacactg
     9001 gatctctgcc gtgtcaaggt gtaacgctgt ccttgctacc ttgcagatac ataaagaaaa
     9061 ggatagcctg gggcctcgaa atggagacca ccctagacca cttactattg tgtatagagc
     9121 tgttgagggt catgttctct gcacatgatc tgtggtttac acttaagatg gctagacact
     9181 tagttacagg gtaagtagaa gcaaatagat caagtaaaac gcccactact gtagctggaa
     9241 tttgtaaact taagttttta agacctctta tttcctatgg atttattctt taatttacag
     9301 tttattctgt aagttgagaa gtaaaataga gaaattaata aatctagatg ttctcagtgt
     9361 ctcattcagg aacgttttac ccctcctcac taaggaattc ccactgtgac ttaaaaatag
     9421 aggtaaatta cttgtgtgca tgtatgtgtc tgtgttttta cacaaatgca aaaatataca
     9481 tcgggggcac gtgtgtgaga tatgaatgtg tgcttgtgta aaaatagaaa ggtaaccgaa
     9541 tgtattatag aaatatgatt tatttagctg agggtattag agttattttc ccattgtttc
     9601 tattttataa acatgccata ttcttggcta tattctgttc aaaggctagc tctgatatca
     9661 cgcgcatttt ctattaactt aggctgtttt taaaagtgac acgagaaaag aagcagattc
     9721 taagaccagc cttttagtta tgagcataac gacgagagag cgagagcgag agcgagagag
     9781 agagagagag agaaagagag agagagaaac agacctagat aggtaacagc tcatatatct
     9841 tttgaagtga tgggaccaga gatttgttga aatattatgt ctagtaaatt ttcttcatat
     9901 tccaagtaat aaactaatat gttttcttgg tcaagttcag aaaacatagg ccttgataag
     9961 gaagctttga aggggctgct tgttgaagga gttggtgggc tcatctcccc atatatactt
    10021 caaagctggt atgatttcag ttgtttgcaa aatatttttt gaaacgaaat tgtgccattg
    10081 gttgtggagt agagcatccc agctctgtcc tctggctgtg ggaaaatcat gcttacctga
    10141 ctatgtggaa ctaaaaagac agacacattc ctgtgtcctg ggagctttgt cattctctgt
    10201 gtggtccttc ctggaacacc tggtgatctg agacggtcaa caagggccaa gtgctccatc
    10261 acacttactt taatatgaag gcgctgtact tagaaatgcc agggcaactc ccaggaacac
    10321 acttgaattg gtagttgtct ttggggcctc agttacttca tcttagatcc agacaaaacc
    10381 caggcaagct ctccatgttg tttttcacac ttgtgttttt gtagcatctc cctgtttcat
    10441 tcactcttgc tttcagattt taagaaacct gcatatttct tgtacatatg catgcaagcg
    10501 aaagaaggga gtttgtactg atgccatttc tcccttcagt tgctggttaa tggaatttgc
    10561 tagaatcaat tcccccttat tgaagggtga aaacagaccc tttgtgtata tctgtacaga
    10621 gatgtgtata tgggatgtgg tggcactttg ctgaatgtga acttgccttg tcaatggaaa
    10681 gattgaaaaa gtattatgtt tatttataca tttgtataaa tctatatata cacgtatgta
    10741 tatgtgtgtg tatagataaa gctatataca tatatttccc taaaatgtgt gtgtgtaata
    10801 gattaacagc ccttgctaag caagattatg catctgtggg aattctgggt tattctgcca
    10861 gccagtggaa atggccacag tgtagagcac atcaccaagc atgctgacgt gggaaccctt
    10921 tggattacag tcacgattac agattagtgc tcacaaacca atctttgaac tcttctttct
    10981 cagatttctg ctagctattc tctcattact taacaatcac acatctttgc caagttgtct
    11041 gttgtccaag tgctggagat tggctcctga ggtggccctg tgctgggcat gtgagaagcc
    11101 acgtccttgg gatgatttag ctctctcact agacacctgg gcatgaatgt gtcagctgtc
    11161 actcaggcct taccaacgac acttccccac ggtatacagc tttcaattat gttttctctg
    11221 agaattgggt agtcatcaaa aataaaaagc caatgttcaa aaacttaatt ctcaatttct
    11281 taacctaggt aactttggag tattttattt acattgaaaa atgtaattat gactttatga
    11341 ttgatattag tgttaggtgt atttccacac ttatcattta aagagtttga tttgctttgt
    11401 gttttaaata taaccattta ccacttgaat tttaacaaag tacacagagt cacatggaag
    11461 cctcttgaat tctataactg actcttgttt ctcatgatga aatgctctaa tgagttcttg
    11521 tgtaataatt ctgctagatt tccttttgac ttctctcaca gttgtgacat tcagttttaa
    11581 ctctgctgca gctctctaga aaacttgcac ccttctatat cgtgccttta aagctcttat
    11641 gcacacacag aagtgtatat atacatgttg gcgcatgtgt acatacactt tggtatatac
    11701 tcacacagta tgtctccagg atatattgtg ggagtggaca tagagatatt caaaggcaat
    11761 gaaatgttgc tctctagata tatatgtata taaatagtgt tgatataact gtacatacac
    11821 gtgtatatgt atgagttcta aatggcaatc ttttacattt agcaaaatgc tgccctactg
    11881 gaatattgcc actgcaatgg cacttgtatg taatgattta aaagacatta tcaaaaatta
    11941 tttaaagaac attaaaggtc tcatctaaag acagccacac actatttatt tagcttccta
    12001 ttcctgtgat tgttgtgttt gtataactgt aagggagact gtcattttaa actcaccacc
    12061 tgtgtaggag agatgagatt cactcggggt actttgtatc ccctctctct gaaacagtga
    12121 tgtgtcacag tccagcttgt ttatctcagt tttaaagcag tcctagtact gccattggtg
    12181 tgtgtcaccc accatgtcct cgatcaactt acttcaccaa tttgcctctt cctttcatta
    12241 ataaataatg atcatttcga tcagtttgcc tgggggaaag ctaactcctc tcttgcttca
    12301 gggaaataga tcatctagct gttgttctgc cttgttcaaa attcaccata gaaagagggt
    12361 ggtcctcata acgctgtctt aagcatagtt tatttttcat ttatttaaag atcttacttt
    12421 tttttttttt tgaaagtact cttaagttgc atgtccttgg catagatttc attcttactg
    12481 cccttcccca caggatattt ttcatagtcc atcagtttcc cataccaaat gcaagaacgt
    12541 caggacaaac tgtcaatact gttgctgttc gcgaggggct ggcagcagat cacacctgga
    12601 atttagaggg agagaaggta gccggataat cctgagccct gtgaagtgga gcgtggaata
    12661 agggtacttc taaggaaaca tttcagggta gctcactgga aattgatatc agaatcagcc
    12721 tttaacagcc tggcagaggg atggtactaa ctacccagcg tgcccaagtg taaacaaacc
    12781 aagctgcagt gggaagtcaa aggtgggagg tagccattgg aaaccaggaa caaagtaact
    12841 gcacggtagc aaggactagc agtctgttct catccacctt ggcacaccga atgctccata
    12901 cgccatacat tcaggacata ggcaggagga cagctgctta aaggggactt acaaaccaag
    12961 caccttctct tgtgtctgtg tcatggctgc cactcagttc caggcatgta caccgggagc
    13021 aactagtttc tgcagaatac aagaggaggc tggcaggctt tggaaaggcc tttccatggc
    13081 gttgcctgtg atttcagtgg ggaggacaca tttggggaga tggctgggct tttggtttgt
    13141 gatttccctt taaacaggaa gagatggttc acactttcca tatatatatc tcaatgaatg
    13201 tactgtatta ctgttttaaa aatttgatga aataataatg gattggtctc cttttgttat
    13261 ctggtccttg tttaatttgt ttaagggttt ttgtatacaa aagtttacat ttttatgtat
    13321 atttttcttg tgtaaaaact gatgtaatat gtgtataaaa cacttgtatg tattatctgt
    13381 atatagtgtg acaaaatgat ttttctttct ttcttttggt tgtattaata aatcttgctg
    13441 tgaagtaa
//
LOCUS       NM_001106915            5498 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus calcium responsive transcription factor (Carf),
            transcript variant 3, mRNA.
ACCESSION   NM_001106915 XM_001069949 XM_217411
VERSION     NM_001106915.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5498)
  AUTHORS   Zheng,F., Zhou,X., Luo,Y., Xiao,H., Wayman,G. and Wang,H.
  TITLE     Regulation of brain-derived neurotrophic factor exon IV
            transcription through calcium responsive elements in cortical
            neurons
  JOURNAL   PLoS One 6 (12), e28441 (2011)
   PUBMED   22174809
REFERENCE   2  (bases 1 to 5498)
  AUTHORS   Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K.,
            Reddel,R.R., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF is a novel protein that cooperates with mouse p19ARF (human
            p14ARF) in activating p53
  JOURNAL   J Biol Chem 277 (40), 37765-37770 (2002)
   PUBMED   12154087
REFERENCE   3  (bases 1 to 5498)
  AUTHORS   Tao,X., West,A.E., Chen,W.G., Corfas,G. and Greenberg,M.E.
  TITLE     A calcium-responsive transcription factor, CaRF, that regulates
            neuronal activity-dependent expression of BDNF
  JOURNAL   Neuron 33 (3), 383-395 (2002)
   PUBMED   11832226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced NM_001106915.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMN16676789
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000009.1  68996617-68996660
            45-203              JAXUCZ010000009.1  69001006-69001164
            204-318             JAXUCZ010000009.1  69003480-69003594
            319-433             JAXUCZ010000009.1  69006443-69006557
            434-556             JAXUCZ010000009.1  69007838-69007960
            557-617             JAXUCZ010000009.1  69020417-69020477
            618-684             JAXUCZ010000009.1  69020655-69020721
            685-814             JAXUCZ010000009.1  69021475-69021604
            815-899             JAXUCZ010000009.1  69023524-69023608
            900-1089            JAXUCZ010000009.1  69027269-69027458
            1090-1210           JAXUCZ010000009.1  69030122-69030242
            1211-1354           JAXUCZ010000009.1  69032846-69032989
            1355-1588           JAXUCZ010000009.1  69034974-69035207
            1589-1751           JAXUCZ010000009.1  69037446-69037608
            1752-1815           JAXUCZ010000009.1  69039185-69039248
            1816-1946           JAXUCZ010000009.1  69040403-69040533
            1947-2313           JAXUCZ010000009.1  69040880-69041246
            2314-5498           JAXUCZ010000009.1  69043296-69046480
FEATURES             Location/Qualifiers
     source          1..5498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..5498
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="calcium responsive transcription factor"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
     exon            1..44
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            45..203
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            204..318
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            319..433
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            434..556
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            557..617
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            618..684
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    648..650
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="upstream in-frame stop codon"
     CDS             660..2423
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="isoform 3 is encoded by transcript variant 3;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 8; calcium-response factor; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 8
                     protein"
                     /codon_start=1
                     /product="calcium-responsive transcription factor isoform
                     3"
                     /protein_id="NP_001100385.1"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
                     /translation="MLASSQMTSVSEEKPIGGSLPAVSTDALEDSASSYSLHSQASLV
                     GPRKSGTRTLEEPLLAPLQPLSCNTPMWACRLRSCEKIGDSYRGYCVSETELESVLTF
                     HKQQTQTVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKG
                     FQLKKISEQESRSCHLYKATCPARIYIKKVQKFPDYRVPTDPQIDRKTIRMEQEKAFT
                     MLKKNLVDAGGVLRWYVQLPTQQAHQYHEPETPGVPLSPSPFPMSPLEEEEAIIRDEN
                     CVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPT
                     VNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFAEGNLLKEP
                     ITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKIFTHLQALKLQPRLSSPDGSQALVSVN
                     SHPSSSPPGLDTAGNAEANNHSLLLGQSQNLGTDTCLPENSSTASPMGSLPESVQNLV
                     AVDQLVGGEDAEDAGNLEGNVKRTLLGDAHTIPIHILDSHPALVEEDTLSMNQVKQEP
                     NEPTLSTEAKTLLDCKNVSAT"
     misc_feature    660..728
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A7U2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1008..1706
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     misc_feature    1008..1706
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     misc_feature    1968..2057
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A7U2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2094..2156
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A7U2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            685..814
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            815..899
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1089
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1210
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1354
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1588
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1751
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1815
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1946
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2313
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..5498
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgtggt ggtctccacg gcggggcctc ggagccaaga cgagaacatg ctacagtgaa
       61 gacagagtca cagcttccat acaaataagc tggcctgctt agaattcagt gctccaaggg
      121 aagaccacca atgaatgcca gaaaaggcat ttctgaggca aaataacagg aatctggact
      181 tgaacttgag ccactgcctg gaggtatggt gagaccaaca gacgaagaga cgattgccat
      241 tgggaagaca gcccattttt cacagttctc gaaaggagtg ggcatgctgt accaccaagt
      301 gccaacaata acaccaagcc attagccaat cagagaaaat gggactgact gagaagccag
      361 catggagcca cgtcactcag taggaggcac ctgtggtgat ggtgagacag aaagagacac
      421 cccaggactc gagaatatac cagagacact gactgacaca caggcccttc atgaagagca
      481 atttcatctt ttggaccaaa atgggcagcc tattcaatat gaccttcagt ctttgggaaa
      541 ttctactgca caaatgacag ggatggagca agtggttata cctcaggagt cgtttgcaga
      601 cgtgtgtagt cctccaggtt atctgtctat ttcattttgg gattttatga agctggctga
      661 tgcttgcttc ctcccaaatg accagtgtct ctgaagagaa gcccattggt gggagtttgc
      721 cagctgtaag cacagatgct ctagaagaca gcgccagtag ctacagtctt cactcacaag
      781 catccctcgt gggacccaga aagtcaggga ccagaactct tgaagaacct ttgctggccc
      841 ctctccagcc actttcttgt aacacaccca tgtgggcctg ccgtcttagg agttgtgaga
      901 aaattggaga ttcctaccgt ggctactgtg taagtgagac tgaattagaa agcgtcctaa
      961 cttttcacaa gcagcaaaca cagactgtct ggggcactcg ccaatctcca agcccagcca
     1021 aacctgccac acgcttgatg tggaagtctc agtatgtccc ctatgacggc atcccgtttg
     1081 tcaatgcagg aagtcgagct gttgtaatgg agtgtcagta tggaccaagg agaaaaggtt
     1141 ttcagttaaa aaaaatcagc gagcaagaaa gtaggtcttg tcatctctac aaagctactt
     1201 gtccagccag gatatacatt aaaaaggtac agaaatttcc tgactataga gtacctactg
     1261 acccccagat tgataggaag acaatccgga tggagcagga gaaagccttc actatgctga
     1321 agaagaacct ggtggacgcg ggcggtgtcc ttcggtggta tgtgcagtta cctacgcagc
     1381 aagctcacca gtatcatgaa ccagagactc ccggtgtccc tttgtcaccg tcacctttcc
     1441 ctatgtctcc tcttgaggaa gaggaggcta taatcagaga tgagaactgt gtgttgccct
     1501 ctcgtctcca cccgcaagta gcgcataaga tccaggagtt agtgtcccag ggagtggggc
     1561 aagtgtatgc agtgaggaag cagctaagaa aatttgtgga aagagaactg ttcaaacctg
     1621 atgaggtacc tgaaagacat aatttatctt tttttccaac tgtaaatgat atcaaaaatc
     1681 atatccacga ggtacagaaa tccttgcaga ctggagatgt ggtatataac tcagagatta
     1741 ttccagcaac gcttcagtgg actacagata gtggaaatat cctcagagag actgtaacag
     1801 ttacatttgc agaaggaaat ttactaaaag agccgattac cagcaaaatg gggacaagtc
     1861 agacacaaac ttctttgtct ccagaaccac ttcccttgct ctccccactt tcttcatttc
     1921 agcccaaaat atttacacat ttacaggctt tgaagttgca gccaagactc tcctctcctg
     1981 atggatccca ggctttggtg tcagtaaata gccatccatc ctccagtccc cccggccttg
     2041 atacggcagg aaatgctgaa gccaataacc actctctact gcttggccag agtcaaaacc
     2101 ttggaacaga cacttgccta cccgagaaca gcagcacggc ctctcccatg ggcagtcttc
     2161 cggagtcagt tcagaaccta gttgcagtgg atcagctggt gggaggtgag gatgctgagg
     2221 atgctgggaa tctggaagga aatgtaaaga ggactctgtt gggagatgca cacaccattc
     2281 caatacacat cctagacagc catccagctc ttgttgaaga agatactctg tccatgaacc
     2341 aagttaaaca agaacccaat gagccaacac tgtctacaga agcaaagact ttgctggact
     2401 gtaaaaacgt gtctgctaca taaatatttc aagtttttca gaatttacag atctggcccc
     2461 ttctgatgtc ttagaaggtg aagattgtca gggcatggta tatcactgga ccagagtgga
     2521 tgatgggcag ttttgactta aaattcaaat atttgttgca aattctatat ttgtatttcc
     2581 cttaagaaat attttacttt attttgtatt cctacaattt ttttattatt cagtaaggca
     2641 agtattttaa aagatcatct atctgaagtt atacatagta atttagtgtg aacgtaaata
     2701 gttatatcca gttttggttc ttacaagaca gaaaagacca acaataaagc agtatgtgag
     2761 tgcacatata ggtgtgtcag aaaatttaaa gctgtgagaa gagttttgat taacagacag
     2821 gtaagagaat acttatcatc tgtttatctg gaaagataga gccatagatt tctatggtag
     2881 catagagcca ccagtcacat ccctcaatgc tgaatttgca gtttatcctc agttttatat
     2941 ctttaactgt aaaggaatgg tactaaaggt catctgtcag aaatttcagt gacttggtaa
     3001 gttttgaaaa gttgaattaa tcagataaat aacacaaatc aatgtatttg gcatattttt
     3061 atatggaatt ggaggcaaat ccctacctag gaatagaaat ataaaaaatt cagagtattg
     3121 gggggaaagg ttagaattcc ctactgttta cagatcattt gggggaactt ttgatgatag
     3181 caaaattttt gttgtttttt aaatattcaa tttcgactag aaaatagttt aaatagtatt
     3241 tacatttttt ctgtactagt gttcttactg aattgatagt attacaattt atatatttca
     3301 aggtaagtat atatagcttc aaatttagtt catatttgaa acattaaaat atctgatctg
     3361 atatttgttt gttaaataag tacatttata cttagtacca aataactagt aaccagtatg
     3421 tttattataa agttgttttc atggaagagt gactaggtag aaatttcaaa tgtaactctc
     3481 atgaaattaa cctagctgaa gggtagtggt gcacgtctgt aatcccagca ctgaggaggg
     3541 agagaacttg gtttgtaaac tcagatttgc ctaggctaca tagtgagacc ttactaagaa
     3601 agaaaggggg atcacctaca agattctttt tctggagatt catttttgag ttatgtaaat
     3661 ttttattttt aaaaataaga acttaaatgg atattaaagt ttaatattca aagcatgaac
     3721 aatgtaattg atacctgacc ttgatacttt atgtggatcg actttcctaa agtctgattt
     3781 cccattatta ttcactttgc tttaggtgta ttacctgtac ctaaagataa aacactgtta
     3841 ttttaaaagt aggcagaact ctaaaattca ttatctttac atctatatcc tagtcaacat
     3901 aaagtttatt atagccctat tgaaagcaaa gttcatatat aattacacgt atgattgtta
     3961 ataggaactg cttttctttt ttaaaagaaa gaactgaaga tatctggtgc cagtatttat
     4021 agcagcagac gactaaacct gaatatatta tactaagttt aatacaactc tagtcacttc
     4081 aaaatctagg ttctcttagt ctgtgcatac ttaacaggaa caagatcaaa ttagtatgta
     4141 gtttaggact gaattacagg tttcgttatc tgtgttatag aaactgtttc aagaacaggt
     4201 tttcatcttt caataatgat tatggtttat tactaaatat tcactcacag aggaatattc
     4261 tcttggagac attctttttt tatttggatt gctaaggaga aatgctgtta aggaacaaac
     4321 tagtcaattt ctgttgtgtg agggcaagga gagaagagca gaggatctga tggttactat
     4381 gtaatcagga acacataccg tgacatgtgt ttctgtcact ccactccacc aggcatagcg
     4441 gcagacacct ttagtttcag tggatctctg tgagctccag ggtagcctgg ccgacacagt
     4501 gagatcagga cagccagagc tacatagtga gacccaggaa gaaagaaaaa aaacatgttt
     4561 ctgtcacttc attctgtttg aataggtctt ctgttaatat tttttatcat gagaatagaa
     4621 agttacatat attcttccca caaacaaaaa gaaaacagaa aactgaacac ttaaatccct
     4681 aattgtatat tcttgcattt ttttaggtag aaactggaac tattaatatt tttgtgtatt
     4741 taaataagta gttcttaaag atggtatcta ataagtttaa aaattcattt gtcttctaaa
     4801 ctcatgtgta gtcacagcgt gtcagtattg gccaaaggtg cttagcatca gtattcgaaa
     4861 actatgttta catatttaaa tgtttaattc tttacaaatg taccagatct taaacacaag
     4921 tgtataaaaa tttcagtctc tgtatttggc attcacttaa caactccaca gcaaactttg
     4981 atagtaccct ttggttcatg tatgacaaga tggagtagga gctgaggggg agctggacat
     5041 ttaaaataag cagttaggaa ttcataatca tagcctggat tgtttctttg tagttttctt
     5101 gttcaaaacc tccaagtaaa ctttgtatat acaccaggaa attatcgatg aaccaccaca
     5161 ggagactttc cccccagtag taattttcta tgtaagcagc caatgtactt aaaaagcttt
     5221 aacatcttat gcaaagtaaa tgtttcctaa ccaccacaga agtgatagga aacatgaact
     5281 ctgggtccgg tattgaagtt tttaatctta gccccagctt gtgcttcatc ttgtttctat
     5341 cctgtcaaac tatatatgta atcatgtggg tatgagacag tgtttacttt ataccgggtt
     5401 tgtaaaaaga tttcaaaatg tgtatgtata tattgtaact tgatgtacag tgttcttatt
     5461 ataatgtaat tttttattaa aaattctgtt ttttctta
//
LOCUS       NM_001437254             821 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17),
            transcript variant 1, mRNA.
ACCESSION   NM_001437254 XM_006249264
VERSION     NM_001437254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 821)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 821)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 821)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 821)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249264.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223326.1, FM103434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000012.1  32587831-32587880   c
            51-190              JAXUCZ010000012.1  32586490-32586629   c
            191-821             JAXUCZ010000012.1  32584816-32585446   c
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..821
                     /gene="Mrps17"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
     exon            1..50
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     exon            51..190
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..451
                     /gene="Mrps17"
                     /note="28S ribosomal protein S17, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_001424183.1"
                     /db_xref="GeneID:288621"
                     /db_xref="RGD:1307650"
                     /translation="MSIVRSAVHAKWVVGKVIGTAMVKTAKVRATRLVLDPYLLKYFN
                     KRKTYFAHDALQQCSVGDIVLLRALPVPRAKHVKHELAEIIFKVGRVIDPVTGKPCAG
                     TAYLESPLSSEATPPCESREELKSS"
     misc_feature    98..319
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     misc_feature    98..319
                     /gene="Mrps17"
                     /note="Ribosomal protein uS17; Region: Ribosomal_uS17;
                     cd00364"
                     /db_xref="CDD:466775"
     exon            191..821
                     /gene="Mrps17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgcc caggctcctc cggccttggt ccgagttgta ggttttggag gcgctcacag
       61 acacataatg tcaatagtcc gttcagccgt ccacgccaaa tgggttgtgg ggaaggtgat
      121 tggtacagca atggtaaaaa ctgctaaagt aagagcgacc agacttgttt tggatcccta
      181 cttactaaag tactttaata agcggaaaac ctactttgct catgacgccc ttcagcagtg
      241 cagcgtcggg gacatcgtgc tcctcagagc tctgcccgtc ccacgagcaa agcacgtgaa
      301 acacgaactg gcagagatca tcttcaaagt gggccgagtt atcgaccccg tcacaggaaa
      361 gccctgtgca ggaaccgcct acctggagag ccccctcagt tcagaagcca ctcccccctg
      421 cgaatctcga gaagagctca agtcctcctg aacctgggga agagggagcc agaggatgga
      481 tgtctgtctg tttgctcagt ggcttttcat actgtttctc ctgtgacatt agaagtattc
      541 aacagagtaa agagcttagc gttccataaa ggttcgcatc ctttttcaga ttctctgccc
      601 tgaagttacc ttccgagtac tctgtatgcc taagcgtgct gcgtcattcc gtaagctcac
      661 tgtcctagat catatatgta ttgttttgtt tgccatcact caaagaaatc ttggactttg
      721 cacctttatt ttaaaagaag aaaacctttt gataataaca gaaaaggcta aacttagttt
      781 cgatagctga atttttcaaa atatatcgtg tgtgtccaca a
//
LOCUS       NM_001436980            5001 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 174 (Gpr174),
            transcript variant 2, mRNA.
ACCESSION   NM_001436980 XM_006257164
VERSION     NM_001436980.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5001)
  AUTHORS   Barnes,M.J., Li,C.M., Xu,Y., An,J., Huang,Y. and Cyster,J.G.
  TITLE     The lysophosphatidylserine receptor GPR174 constrains regulatory T
            cell development and function
  JOURNAL   J Exp Med 212 (7), 1011-1020 (2015)
   PUBMED   26077720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006257164.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000021.1  76428466-76428568
            104-207             JAXUCZ010000021.1  76428799-76428902
            208-289             JAXUCZ010000021.1  76442344-76442425
            290-5001            JAXUCZ010000021.1  76464314-76469025
FEATURES             Location/Qualifiers
     source          1..5001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..5001
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="G protein-coupled receptor 174"
                     /db_xref="GeneID:302373"
                     /db_xref="RGD:1564689"
     exon            1..103
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            104..207
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            208..289
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            290..5001
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    823..825
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="upstream in-frame stop codon"
     CDS             853..1860
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 174"
                     /protein_id="NP_001423909.1"
                     /db_xref="GeneID:302373"
                     /db_xref="RGD:1564689"
                     /translation="MTDNFTCNKTDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVF
                     YGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM
                     YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDD
                     TPGNRTKCFVDLPIRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPI
                     SQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSV
                     ALCLASLNSCLDPVIYYFTTNEFRRRLSRQELPDSIQLQTKSYKIVNNHGASPTAAEL
                     C"
     misc_feature    910..1761
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative purinergic receptor GPR174, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR174-like; cd15152"
                     /db_xref="CDD:320280"
     misc_feature    910..1761
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative purinergic receptor GPR174, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR174-like; cd15152"
                     /db_xref="CDD:320280"
     misc_feature    910..993
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320280"
     misc_feature    910..993
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320280"
     misc_feature    1012..1089
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320280"
     misc_feature    1012..1089
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320280"
     misc_feature    order(1075..1077,1084..1089,1123..1140,1144..1149,
                     1156..1158,1288..1290,1294..1308,1396..1398,1405..1413,
                     1417..1425,1429..1434,1579..1581,1588..1593,1597..1602,
                     1609..1611,1660..1665,1669..1677,1684..1686,1693..1698)
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320280"
     misc_feature    order(1075..1077,1084..1089,1123..1140,1144..1149,
                     1156..1158,1288..1290,1294..1308,1396..1398,1405..1413,
                     1417..1425,1429..1434,1579..1581,1588..1593,1597..1602,
                     1609..1611,1660..1665,1669..1677,1684..1686,1693..1698)
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320280"
     misc_feature    1123..1215
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320280"
     misc_feature    1123..1215
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320280"
     misc_feature    1246..1314
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320280"
     misc_feature    1246..1314
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320280"
     misc_feature    1396..1485
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320280"
     misc_feature    1396..1485
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320280"
     misc_feature    1519..1611
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320280"
     misc_feature    1519..1611
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320280"
     misc_feature    1663..1740
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320280"
     misc_feature    1663..1740
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320280"
ORIGIN      
        1 gagagcgcgc gctgctcacc cactagaaaa cggaaatgtt caatgtgttc agaaacgctt
       61 gcatatttca ttctgacaac tcactaccat attttccaac atgaaaacgg agctggatcg
      121 gtgcacagat cagtagcatc ctcattggag tggctgtcac atgaattctt tggagatttc
      181 tggagaaaag agaaagaaac tgaaacggca tgaatgaatt aatcatccct gttatcacag
      241 catctgcaga ggatctgatt aagagcttct atcagcactg gataaaacag tttgtatttt
      301 attctctctc tcatgctctt cttcaatgta tatctgaaaa agtctcagaa aaaaaaaaga
      361 accaccaaag taagtcatct ttggacagtg gcagagccac cctgcactga agcaaacctt
      421 tcttctgtgt gatccagact tctctccctc aaaagaacat aaaatgtcct tccaaacacc
      481 tgtacagtga tgactatcat atgggaattt gaaaagctga agtatgacat agttatgaat
      541 caagtgagaa atatccaatt tccatgatgt cctggaaagc cttaccacaa aataaacaag
      601 aggagaaaat ttgaacaact tttcatgtgt gcttacacaa tggagttctg taattgtgta
      661 tacaaatctg acgcataaat acagccagtt ttttttaaag ctcccaaatc atatgtagag
      721 gctaacaatt gtggcaaaag gttgttttat actctgtctt tctgacccac tgacttgtgg
      781 acagtacaga agttactgtg gatttagatt ttgaatgacc agtaggcaaa gacaatttct
      841 ctggaaataa tcatgactga taattttaca tgtaacaaga cagatggaga caatacagat
      901 ttccggtact tcatttatgc agtgacatac actgtgattc ttgtgccagg tctcataggg
      961 aatatattag ctttgtgggt attttatggc tatatgaaag aaaccaaaag ggctgtggtg
     1021 tttatgataa acctagccat tgctgactta ttacagattc tctctttgcc actgagaatc
     1081 ttttactact tgaaccacga ctggccattt ggtcctggtc tctgcatgtt ttgtttctac
     1141 ctgaaatatg ttaacatgta tgccagcatc tacttcttgg tctgtatcag tgtgcgaagg
     1201 ttttggtttc ttatgtaccc ctttcgtttc aatgactgca agcagaaata tgacttgtat
     1261 atcagcattg ttggctggct gatcatctgc cttgcctgcc tactctttcc tctcctcaga
     1321 accaatgatg ataccccagg taacagaacc aaatgctttg tggatcttcc tatcaggaat
     1381 gtcaatctgg cccaatctgt tgccatgata actattggag aggtggttgg gtttattact
     1441 cctcttatga ttgttctata ctgtacctgg aagacagctt tgtcattaca aaataaatat
     1501 cccatttctc agcatcttgg agagaaaaag aaagccctga ggatgattct gacctgtgca
     1561 gcggtgtttc taatttgctt tgcaccttat cacttcagct ttcctttaga tttcctagtt
     1621 aagtccaatg aaatcaaaag ctgcttagcc agaagagtga ttctaatatt tcattctgtg
     1681 gccctgtgtc tggcaagtct aaactcctgc cttgacccag ttatatatta tttcaccact
     1741 aatgagttca gaagacgtct ttcaagacaa gaactgcctg atagcatcca actccaaaca
     1801 aaatcatata aaattgtgaa taaccatggc gcctctccca cggcagctga actgtgctaa
     1861 ataaaacctg aaactgaatg tggccttgaa tgccacatcc ccatcaagac agtcttcata
     1921 gaaaatactc ataacctttc agtgtgctct atattacgta catggagaat gcacatactt
     1981 atgacaatac ctgttagaat attatgtttc attttcattg ctggtgacat gtccgtgcag
     2041 taacgccaga ccaggtcttt gagacttaag tggtaaagtt ttgataatgc tctgtgcaca
     2101 tatgctctga gctagactca tcagctttat ctgtgaacct aagtcacaaa gagattacta
     2161 tctcaagccc agtttaagca ctgagttttt tacctcagat gctgaatctc tatttaaaat
     2221 gtgtgcaatg gtcaatttgt agtagtgatc acagtttgca ttccaaaaac atatttggtt
     2281 gtgcttcatt aaagtgaggt gggcaatact ttatgtacac acaatgttac aaaaataggg
     2341 ttatttttat ctcccacgtg tgattccatt aaaggatttg aaactccaat gcttgatttc
     2401 ttcagttagc gtcaatgtga aacatcatct gtcatgttag ttgttgaatg aaattctgaa
     2461 atcaggattg ggtacactta aaataagaac aacatccata acacacaata atcctctgca
     2521 attgtataaa atgctacatt gaatattccc aaggcaggta gttttctaca gttaacccag
     2581 catgactcag ttgcccttta tgctttagag aaaggaaaga ggtgccaacc acaaggctct
     2641 ctgaaactag ttccaaagaa caccttcaga aatgtatgaa cctgtctagg agagggatag
     2701 tttttcatca taacttagaa ttacattgaa gaaatctgac aggttattac tgaaataaac
     2761 agtgtgccaa ttagtcacta agcttgggca gagtgaaaat atgaaccaaa gtgaagcata
     2821 agacttaaaa ttactattgt ccttcataaa ttccccaagg taaatggtgc ctatctaggc
     2881 atctacaaaa gccagagtaa gacacaaaga tactggtctt cttaagtcta cattttttag
     2941 ataggttata tgattattat gactactaag catatacgga ttacctctca aaaactgtgg
     3001 aaagcaattc tttcaccttt tgagaagagc gtacatgatt ccagtagcct tacacattcc
     3061 ttacaaaaac tttgtctact accagtttag actactgagc aggaagaact ctggtatgtg
     3121 acagtaatgt gacagtactg gaatattctg aagcatgata tacattgtaa ataagattac
     3181 tttaaaaaaa tccttcaata gagaatgggg agaaaacact cttctttaca ttgagcaaat
     3241 acagaaatca aacaagacat atatgtatat atgcatacag tgcagtttta ggtatataag
     3301 ttaatgatac tgcatgtctt tggggaaatt cattaaatcg acatgaattt tagcttgtaa
     3361 aactagtgag aaacttctaa agtttggtct gagtaagtaa caaaaaagta ttgtttatgt
     3421 ttgtacagtt tatgaaaata atggattagg aaaatgagtt tgtgctgcta gcaaaagtat
     3481 atttatatat ttcctagtta ttctttgtaa tgtacatgtg ttttgatgta ttaaataagt
     3541 gttaactttt gttttcaaaa gagaaactat aaatgtgtgt ggtctatttg tttagaagtg
     3601 atttctagtt gactgtaatt tggtattgta atgagattac gagtaatcat ttgtgaaact
     3661 atgaaacaat tgtgggtgct tgaaatagtg ctcatagtac tcatacttaa aatagctatg
     3721 cttaccattt cttgtagcat gagttacact ttttaaagtc actttgagag atcactaaac
     3781 tttttctaac attgattcta ctatactcgt accattttta agggaaagga aatgctccta
     3841 ggacattatt aaccattgta gagtggctga gagtccagct cacttgttaa atagtcctct
     3901 gtcatttagc ggtaagtcaa gtgtctaatg gttttatgct atttctctac ccagacctgt
     3961 ctatctgggt ttgtattcag catctgaata ctgaatcaga atcatttcct gattcttcat
     4021 cttcctcatc aacacatttg aattttgctt tacccccttc tgatcaactt attcacaata
     4081 aggtgctaat tataatgtta acttcatatc catttaccaa gatatatctg aagttcatac
     4141 cttagaaata ggcattaaca caaagtggtg aaattcaaat ggagcgattt caggcacagg
     4201 gagctgtggt ggaggggaag acattgtaaa gtaagtgagc cttacagcaa tcttttcaaa
     4261 taatgcatta taaataccca tctacttcag ttgccattgt aaggatgcta aattccaaga
     4321 aatagctcca taaacatttt acagattttc gcttgagatt ttttctttta ccctttccct
     4381 cttctaacac tggacttaag ttttcagaga ataaaaacta acattggaga gaaatagtgc
     4441 ttcatctacc ccaagtagct gcttctttat tgagattcca ttctccttgg aaaatctttt
     4501 cttcaaatcg cttatttatc attttgagtt ccatacgatt gagttcaaag agaatctgaa
     4561 ttatgacagt gtataattaa agataaatca tctcatatta cttttgtaaa gttgtgaatt
     4621 ttttgtctca aaattaatca attattttaa taagaaaatt tgaatataga ttgtcttaat
     4681 gctaataata ttgcctttat tgctgccttt attattttaa tgaaattgtt tttatgttac
     4741 atgttttcat tttcatgtaa taaaccagca aatcctatta atcagtagtt tatgaagagg
     4801 agccatttgg ccaatgaata acagaccaac ttaccatgct ctgtgaggat tcaccagtgg
     4861 aactctgcac aacttaattt ttatgccacc ttttgggtta acttccaaga tactgtgaaa
     4921 tgttgttatt ggagtttatt tacagctctt atttatcata tggattttaa taataaagtt
     4981 tatctctgta attaaatggg a
//
LOCUS       NM_001437220            3017 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), transcript variant
            5, mRNA.
ACCESSION   NM_001437220 XM_008769125
VERSION     NM_001437220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3017)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 3017)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 3017)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 3017)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 3017)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 3017)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 3017)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 3017)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 3017)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 3017)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_008769125.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166451.1, SRR26643286.34952.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000012.1  24761121-24761362   c
            243-296             JAXUCZ010000012.1  24760247-24760300   c
            297-543             JAXUCZ010000012.1  24759745-24759991   c
            544-721             JAXUCZ010000012.1  24759477-24759654   c
            722-862             JAXUCZ010000012.1  24756632-24756772   c
            863-974             JAXUCZ010000012.1  24756440-24756551   c
            975-1097            JAXUCZ010000012.1  24756223-24756345   c
            1098-1214           JAXUCZ010000012.1  24754191-24754307   c
            1215-1354           JAXUCZ010000012.1  24753946-24754085   c
            1355-1518           JAXUCZ010000012.1  24752946-24753109   c
            1519-1638           JAXUCZ010000012.1  24751630-24751749   c
            1639-1721           JAXUCZ010000012.1  24749484-24749566   c
            1722-1785           JAXUCZ010000012.1  24749332-24749395   c
            1786-1853           JAXUCZ010000012.1  24749165-24749232   c
            1854-1930           JAXUCZ010000012.1  24749003-24749079   c
            1931-2015           JAXUCZ010000012.1  24748839-24748923   c
            2016-2243           JAXUCZ010000012.1  24748522-24748749   c
            2244-2384           JAXUCZ010000012.1  24748072-24748212   c
            2385-3017           JAXUCZ010000012.1  24744468-24745100   c
FEATURES             Location/Qualifiers
     source          1..3017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3017
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..242
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    177..179
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="upstream in-frame stop codon"
     exon            243..296
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2660
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001424149.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     misc_feature    330..341
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Endocytosis signal. /evidence=ECO:0000255"
     misc_feature    336..395
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    507..569
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GUY2.1);
                     transmembrane region"
     misc_feature    678..>839
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    678..>839
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Zinc peptidases M18, M20, M28, and M42; Region:
                     Zinc_peptidase_like; cl14876"
                     /db_xref="CDD:472712"
     misc_feature    879..1451
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    879..1451
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Protease-associated domain containing proteins like
                     transferrin receptor (TfR). This group contains various PA
                     domain-containing proteins similar to human TfR1 and TfR2.
                     TfR1 and TfR2 are type II membrane proteins, belonging to
                     the peptidase M28 family; Region: PA_TfR; cd02128"
                     /db_xref="CDD:239043"
     misc_feature    966..968
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    order(1155..1157,1197..1208,1212..1214,1224..1235,
                     1242..1244,1248..1256)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1155..1157,1197..1208,1212..1214,1224..1235,
                     1242..1244,1248..1256)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/protease-like domain interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1227..1229,1245..1247)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1227..1229,1245..1247)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="PA/helical domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1242..1244,1251..1253)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1242..1244,1251..1253)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Ca2+ binding [ion binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1254..1256,1260..1262,1272..1277)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    order(1254..1256,1260..1262,1272..1277)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239043"
     misc_feature    1263..1265
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    1473..2174
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    1473..2174
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="M28 Zn-peptidase Transferrin Receptor family;
                     Region: M28_TfR; cd09848"
                     /db_xref="CDD:349946"
     misc_feature    order(1494..1496,1500..1502,1509..1511,1515..1520,
                     1524..1526,1656..1658,1662..1664,1713..1715,1722..1748)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    order(1494..1496,1500..1502,1509..1511,1515..1520,
                     1524..1526,1656..1658,1662..1664,1713..1715,1722..1748)
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349946"
     misc_feature    1866..1868
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B2GUY2.1); glycosylation site"
     misc_feature    2253..2627
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     misc_feature    2253..2627
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="Transferrin receptor-like dimerization domain;
                     Region: TFR_dimer; pfam04253"
                     /db_xref="CDD:461238"
     exon            297..543
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..721
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..862
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..974
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1097
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1214
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1354
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1518
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1638
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1721
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1785
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1853
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1930
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2015
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2243
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2384
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..3017
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacctgt tgctgagttg aacttggctg ctgtgtcttc ccactcagga ctcggctttg
       61 acaggcacga ggcagggact ggggtgagcc cctacctctc agatctttct ggacctgggt
      121 aggacctgca gtttcccagg ggagacccgg accgggagta agggtgaggt ggaccctgac
      181 ctttcccatc cacagctgcg ggtcctggga tcttcagcgc ggcttggatt tcaaactgga
      241 ggggttcagg agggggcaca agcatggaac aacgttgggg tctacttcgg aaagtgcaac
      301 agtggtcccc aagaccctct cagaccatct acagacgtgt ggaaggccct caactggaga
      361 acctagagga ggaagatagg gaggaagggg aggagcttcc tgcccagttc tgccccatgg
      421 aactcaaagg ccctgagcgc ttaggctcct gtcctgggag gtccattccc ataccctggg
      481 ctgcagcagg tcgaaaggct gctccctatc tggtcctgac caccctgcta atcttcactg
      541 gggccttcct cctgggctac gtggcctttc gagggtcctg ccaggcatgt ggggactctg
      601 tgttggtggt tggtgaagat gtcaactctg aggactccag ccggggcacg ttgtactgga
      661 gtgacctcca ggacatgttt ctccggttcc ttggggaggg acgcatggag gacaccatca
      721 ggctgaccag cctccgggaa cgcgtggccg gctcagccag aatggccacc ctggtccaag
      781 acatcctcga taagctctcg cgccagaagc tggaccacgt gtggactgac acgcactatg
      841 tgggacttca gttcccggac ccggctcacc ctaacaccct gcactgggtg ggtgcagacg
      901 ggagcgtcca agagcagcta ccgctggagg atccggaagt ctactgtccc tacagcgcca
      961 cgggcaacgc cacgggcaag cttgtgtacg cccactacgg gcggcgggag gacctgcagg
     1021 acctgaaagc caaggacgtg gagctggccg gcagcctcct gctagtgcgt gctgggatta
     1081 caagcttcgc ccagaaggta gccattgccc aggactttgg ggcccacgga gtgctgatat
     1141 accctgaccc agcggacttc tcccaagacc cccacaagcc aggcctgtct agtgacaggg
     1201 ctgtgtatgg acatgtgcac ctgggaactg gggaccctta cacgcctggc ttcccgtcct
     1261 tcaatcaaac ccagttccct ccagtagaat catcggggct tcccaacatc cctgcccagc
     1321 ccatcagtgc cgacgttgct gatcgcttgc tcaggaaact cacaggtccc gtggctcctc
     1381 aggaatggaa gggtcgcctc tcagactctc cgtatcgcct gggacctggg ccaggcttac
     1441 gccttgtggt caacaaccac agaacctcta ctcccatcag taacatcttt gcgtgcatcg
     1501 agggcttcgc agagccagat cactatgtcg ttatcggggc ccagagggat gcctggggcc
     1561 caggagcagc caagtctgca gtggggactg ccatcctcct ggagctggtt cggacctttt
     1621 cctccatggt cagcagtggc tttagacctc gaagaagtct tttgttcatc agctgggacg
     1681 gaggtgactt tggcagcgtg ggagccacgg agtggttgga gggctacctc agcgtgctac
     1741 acctcaaagc tgtcgtgtat gtgagcctgg acaactccgt gttgggagac ggcaaattcc
     1801 atgctaagac cagccccctt ctcgtcagcc tcattgagaa tatcctgaag caggtggatt
     1861 cccctaacca cagtggacag acactctacg atcaagtggc attcacccac ccaagctggg
     1921 atgctgaagt gatccagccc ctgcccatgg acagcagcgc atattccttc acagcttttg
     1981 cgggcgtccc agctgtggag ttctccttca tggaggacga tagggtgtac ccattcctgc
     2041 acacgaagga ggacacgtat gagaatctgc acaagatgct gcgaggtcgc ctgcccgccg
     2101 tggtcctagc agtggctcag ctcgctggtc agctcctcat ccgactgagc cacgatcacc
     2161 tactgccgct ggacttcggc cgctacggag acgtggtcct caggcacatc ggcaacctta
     2221 atgagttctc tggggacctc aaggcgcgcg ggctgaccct gcagtgggtg tactctgcaa
     2281 ggggggacta tatccgggcg gcggagaagc tgcggaagga gatttacagc tcggagcaga
     2341 gcgatgagcg tctgatgcgc atgtacaacg tgcgcatcat gagggtggag ttctacttcc
     2401 tgtcccagta cgtgtcgccg gccgactccc cattccgcca cattttccta ggccaaggcg
     2461 accacacttt gggtgccctg gtggaacacc tacggatgct gcgctccgat ggctcaggag
     2521 ctgcctcttc tgggttgagc ccaggtctgg gcttccagga gagtcgcttc cggcgacagc
     2581 tggcgctgct cacgtggacg ctacaggggg cagccaacgc actcagtggc gacgtttgga
     2641 acatcgacaa taacttttga ggccagaagt cctccatggg ccccacgtga ttctcctttc
     2701 tccctatttg agtggtgcag gcaacggagg tgcctgagag caacctatcc tcattaacaa
     2761 ccttggtcct gcaacgccag tgagacatat tttctcagtg tgactgttat accactgttt
     2821 atccagaaag cggttttctt cccatcactg gcctctctgc cttcaggagc atagttcccc
     2881 atatctagaa accatctaga cactgggatc cagctctctt agcgggtgag atggatagcg
     2941 tcattttctt atgacacaca agtggtatgt gggtggccca agggggatta gatgtcaata
     3001 aaccatttac ctggtaa
//
LOCUS       NM_001106938            5005 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 174 (Gpr174),
            transcript variant 1, mRNA.
ACCESSION   NM_001106938 XM_001059397 XM_006257163 XM_228495
VERSION     NM_001106938.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5005)
  AUTHORS   Barnes,M.J., Li,C.M., Xu,Y., An,J., Huang,Y. and Cyster,J.G.
  TITLE     The lysophosphatidylserine receptor GPR174 constrains regulatory T
            cell development and function
  JOURNAL   J Exp Med 212 (7), 1011-1020 (2015)
   PUBMED   26077720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Mar 25, 2025 this sequence version replaced
            XM_006257163.5, NM_001106938.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.65766.1,
                                           SRR26643284.21515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680445, SAMN06680453
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000021.1  76428466-76428568
            104-207             JAXUCZ010000021.1  76428799-76428902
            208-293             JAXUCZ010000021.1  76442344-76442429
            294-5005            JAXUCZ010000021.1  76464314-76469025
FEATURES             Location/Qualifiers
     source          1..5005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..5005
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="G protein-coupled receptor 174"
                     /db_xref="GeneID:302373"
                     /db_xref="RGD:1564689"
     exon            1..103
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            104..207
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            208..293
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     exon            294..5005
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    827..829
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="upstream in-frame stop codon"
     CDS             857..1864
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 174"
                     /protein_id="NP_001100408.1"
                     /db_xref="GeneID:302373"
                     /db_xref="RGD:1564689"
                     /translation="MTDNFTCNKTDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVF
                     YGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNM
                     YASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIVGWLIICLACLLFPLLRTNDD
                     TPGNRTKCFVDLPIRNVNLAQSVAMITIGEVVGFITPLMIVLYCTWKTALSLQNKYPI
                     SQHLGEKKKALRMILTCAAVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSV
                     ALCLASLNSCLDPVIYYFTTNEFRRRLSRQELPDSIQLQTKSYKIVNNHGASPTAAEL
                     C"
     misc_feature    914..1765
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative purinergic receptor GPR174, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR174-like; cd15152"
                     /db_xref="CDD:320280"
     misc_feature    914..1765
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative purinergic receptor GPR174, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR174-like; cd15152"
                     /db_xref="CDD:320280"
     misc_feature    914..997
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320280"
     misc_feature    914..997
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320280"
     misc_feature    1016..1093
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320280"
     misc_feature    1016..1093
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320280"
     misc_feature    order(1079..1081,1088..1093,1127..1144,1148..1153,
                     1160..1162,1292..1294,1298..1312,1400..1402,1409..1417,
                     1421..1429,1433..1438,1583..1585,1592..1597,1601..1606,
                     1613..1615,1664..1669,1673..1681,1688..1690,1697..1702)
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320280"
     misc_feature    order(1079..1081,1088..1093,1127..1144,1148..1153,
                     1160..1162,1292..1294,1298..1312,1400..1402,1409..1417,
                     1421..1429,1433..1438,1583..1585,1592..1597,1601..1606,
                     1613..1615,1664..1669,1673..1681,1688..1690,1697..1702)
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320280"
     misc_feature    1127..1219
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320280"
     misc_feature    1127..1219
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320280"
     misc_feature    1250..1318
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320280"
     misc_feature    1250..1318
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320280"
     misc_feature    1400..1489
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320280"
     misc_feature    1400..1489
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320280"
     misc_feature    1523..1615
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320280"
     misc_feature    1523..1615
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320280"
     misc_feature    1667..1744
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320280"
     misc_feature    1667..1744
                     /gene="Gpr174"
                     /gene_synonym="RGD1564689"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320280"
ORIGIN      
        1 gagagcgcgc gctgctcacc cactagaaaa cggaaatgtt caatgtgttc agaaacgctt
       61 gcatatttca ttctgacaac tcactaccat attttccaac atgaaaacgg agctggatcg
      121 gtgcacagat cagtagcatc ctcattggag tggctgtcac atgaattctt tggagatttc
      181 tggagaaaag agaaagaaac tgaaacggca tgaatgaatt aatcatccct gttatcacag
      241 catctgcaga ggatctgatt aagagcttct atcagcactg gataaaacag taggtttgta
      301 ttttattctc tctctcatgc tcttcttcaa tgtatatctg aaaaagtctc agaaaaaaaa
      361 aagaaccacc aaagtaagtc atctttggac agtggcagag ccaccctgca ctgaagcaaa
      421 cctttcttct gtgtgatcca gacttctctc cctcaaaaga acataaaatg tccttccaaa
      481 cacctgtaca gtgatgacta tcatatggga atttgaaaag ctgaagtatg acatagttat
      541 gaatcaagtg agaaatatcc aatttccatg atgtcctgga aagccttacc acaaaataaa
      601 caagaggaga aaatttgaac aacttttcat gtgtgcttac acaatggagt tctgtaattg
      661 tgtatacaaa tctgacgcat aaatacagcc agtttttttt aaagctccca aatcatatgt
      721 agaggctaac aattgtggca aaaggttgtt ttatactctg tctttctgac ccactgactt
      781 gtggacagta cagaagttac tgtggattta gattttgaat gaccagtagg caaagacaat
      841 ttctctggaa ataatcatga ctgataattt tacatgtaac aagacagatg gagacaatac
      901 agatttccgg tacttcattt atgcagtgac atacactgtg attcttgtgc caggtctcat
      961 agggaatata ttagctttgt gggtatttta tggctatatg aaagaaacca aaagggctgt
     1021 ggtgtttatg ataaacctag ccattgctga cttattacag attctctctt tgccactgag
     1081 aatcttttac tacttgaacc acgactggcc atttggtcct ggtctctgca tgttttgttt
     1141 ctacctgaaa tatgttaaca tgtatgccag catctacttc ttggtctgta tcagtgtgcg
     1201 aaggttttgg tttcttatgt acccctttcg tttcaatgac tgcaagcaga aatatgactt
     1261 gtatatcagc attgttggct ggctgatcat ctgccttgcc tgcctactct ttcctctcct
     1321 cagaaccaat gatgataccc caggtaacag aaccaaatgc tttgtggatc ttcctatcag
     1381 gaatgtcaat ctggcccaat ctgttgccat gataactatt ggagaggtgg ttgggtttat
     1441 tactcctctt atgattgttc tatactgtac ctggaagaca gctttgtcat tacaaaataa
     1501 atatcccatt tctcagcatc ttggagagaa aaagaaagcc ctgaggatga ttctgacctg
     1561 tgcagcggtg tttctaattt gctttgcacc ttatcacttc agctttcctt tagatttcct
     1621 agttaagtcc aatgaaatca aaagctgctt agccagaaga gtgattctaa tatttcattc
     1681 tgtggccctg tgtctggcaa gtctaaactc ctgccttgac ccagttatat attatttcac
     1741 cactaatgag ttcagaagac gtctttcaag acaagaactg cctgatagca tccaactcca
     1801 aacaaaatca tataaaattg tgaataacca tggcgcctct cccacggcag ctgaactgtg
     1861 ctaaataaaa cctgaaactg aatgtggcct tgaatgccac atccccatca agacagtctt
     1921 catagaaaat actcataacc tttcagtgtg ctctatatta cgtacatgga gaatgcacat
     1981 acttatgaca atacctgtta gaatattatg tttcattttc attgctggtg acatgtccgt
     2041 gcagtaacgc cagaccaggt ctttgagact taagtggtaa agttttgata atgctctgtg
     2101 cacatatgct ctgagctaga ctcatcagct ttatctgtga acctaagtca caaagagatt
     2161 actatctcaa gcccagttta agcactgagt tttttacctc agatgctgaa tctctattta
     2221 aaatgtgtgc aatggtcaat ttgtagtagt gatcacagtt tgcattccaa aaacatattt
     2281 ggttgtgctt cattaaagtg aggtgggcaa tactttatgt acacacaatg ttacaaaaat
     2341 agggttattt ttatctccca cgtgtgattc cattaaagga tttgaaactc caatgcttga
     2401 tttcttcagt tagcgtcaat gtgaaacatc atctgtcatg ttagttgttg aatgaaattc
     2461 tgaaatcagg attgggtaca cttaaaataa gaacaacatc cataacacac aataatcctc
     2521 tgcaattgta taaaatgcta cattgaatat tcccaaggca ggtagttttc tacagttaac
     2581 ccagcatgac tcagttgccc tttatgcttt agagaaagga aagaggtgcc aaccacaagg
     2641 ctctctgaaa ctagttccaa agaacacctt cagaaatgta tgaacctgtc taggagaggg
     2701 atagtttttc atcataactt agaattacat tgaagaaatc tgacaggtta ttactgaaat
     2761 aaacagtgtg ccaattagtc actaagcttg ggcagagtga aaatatgaac caaagtgaag
     2821 cataagactt aaaattacta ttgtccttca taaattcccc aaggtaaatg gtgcctatct
     2881 aggcatctac aaaagccaga gtaagacaca aagatactgg tcttcttaag tctacatttt
     2941 ttagataggt tatatgatta ttatgactac taagcatata cggattacct ctcaaaaact
     3001 gtggaaagca attctttcac cttttgagaa gagcgtacat gattccagta gccttacaca
     3061 ttccttacaa aaactttgtc tactaccagt ttagactact gagcaggaag aactctggta
     3121 tgtgacagta atgtgacagt actggaatat tctgaagcat gatatacatt gtaaataaga
     3181 ttactttaaa aaaatccttc aatagagaat ggggagaaaa cactcttctt tacattgagc
     3241 aaatacagaa atcaaacaag acatatatgt atatatgcat acagtgcagt tttaggtata
     3301 taagttaatg atactgcatg tctttgggga aattcattaa atcgacatga attttagctt
     3361 gtaaaactag tgagaaactt ctaaagtttg gtctgagtaa gtaacaaaaa agtattgttt
     3421 atgtttgtac agtttatgaa aataatggat taggaaaatg agtttgtgct gctagcaaaa
     3481 gtatatttat atatttccta gttattcttt gtaatgtaca tgtgttttga tgtattaaat
     3541 aagtgttaac ttttgttttc aaaagagaaa ctataaatgt gtgtggtcta tttgtttaga
     3601 agtgatttct agttgactgt aatttggtat tgtaatgaga ttacgagtaa tcatttgtga
     3661 aactatgaaa caattgtggg tgcttgaaat agtgctcata gtactcatac ttaaaatagc
     3721 tatgcttacc atttcttgta gcatgagtta cactttttaa agtcactttg agagatcact
     3781 aaactttttc taacattgat tctactatac tcgtaccatt tttaagggaa aggaaatgct
     3841 cctaggacat tattaaccat tgtagagtgg ctgagagtcc agctcacttg ttaaatagtc
     3901 ctctgtcatt tagcggtaag tcaagtgtct aatggtttta tgctatttct ctacccagac
     3961 ctgtctatct gggtttgtat tcagcatctg aatactgaat cagaatcatt tcctgattct
     4021 tcatcttcct catcaacaca tttgaatttt gctttacccc cttctgatca acttattcac
     4081 aataaggtgc taattataat gttaacttca tatccattta ccaagatata tctgaagttc
     4141 ataccttaga aataggcatt aacacaaagt ggtgaaattc aaatggagcg atttcaggca
     4201 cagggagctg tggtggaggg gaagacattg taaagtaagt gagccttaca gcaatctttt
     4261 caaataatgc attataaata cccatctact tcagttgcca ttgtaaggat gctaaattcc
     4321 aagaaatagc tccataaaca ttttacagat tttcgcttga gattttttct tttacccttt
     4381 ccctcttcta acactggact taagttttca gagaataaaa actaacattg gagagaaata
     4441 gtgcttcatc taccccaagt agctgcttct ttattgagat tccattctcc ttggaaaatc
     4501 ttttcttcaa atcgcttatt tatcattttg agttccatac gattgagttc aaagagaatc
     4561 tgaattatga cagtgtataa ttaaagataa atcatctcat attacttttg taaagttgtg
     4621 aattttttgt ctcaaaatta atcaattatt ttaataagaa aatttgaata tagattgtct
     4681 taatgctaat aatattgcct ttattgctgc ctttattatt ttaatgaaat tgtttttatg
     4741 ttacatgttt tcattttcat gtaataaacc agcaaatcct attaatcagt agtttatgaa
     4801 gaggagccat ttggccaatg aataacagac caacttacca tgctctgtga ggattcacca
     4861 gtggaactct gcacaactta atttttatgc caccttttgg gttaacttcc aagatactgt
     4921 gaaatgttgt tattggagtt tatttacagc tcttatttat catatggatt ttaataataa
     4981 agtttatctc tgtaattaaa tggga
//
LOCUS       NM_001437396            1607 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 68 (Ccdc68),
            transcript variant 4, mRNA.
ACCESSION   NM_001437396 XM_039096659
VERSION     NM_001437396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096659.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1973836.1,
                                           SRR26643291.40897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000018.1  65817263-65817401
            140-264             JAXUCZ010000018.1  65830766-65830890
            265-351             JAXUCZ010000018.1  65832026-65832112
            352-486             JAXUCZ010000018.1  65837996-65838130
            487-612             JAXUCZ010000018.1  65840508-65840633
            613-741             JAXUCZ010000018.1  65841071-65841199
            742-824             JAXUCZ010000018.1  65848350-65848432
            825-930             JAXUCZ010000018.1  65852302-65852407
            931-1014            JAXUCZ010000018.1  65853741-65853824
            1015-1091           JAXUCZ010000018.1  65856970-65857046
            1092-1607           JAXUCZ010000018.1  65859014-65859529
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1607
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="coiled-coil domain containing 68"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
     exon            1..139
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="upstream in-frame stop codon"
     exon            140..264
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1149
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="isoform 3 is encoded by transcript variant 4; CTCL
                     tumor antigen se57-1; coiled-coil domain-containing
                     protein 68"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 68 isoform
                     3"
                     /protein_id="NP_001424325.1"
                     /db_xref="GeneID:291530"
                     /db_xref="RGD:1561424"
                     /translation="MTTVTVTMEVPSGGKTEDRSIFSGPSSAQIIEETEYVRKIRTTL
                     EKIRNRMFKEEDGRGNARHKVDAEQSGNVQNGLDSTTDPTRLDLLLESMRRKDQQLLE
                     MNKENEVLQIKLEASREAGAAALRNAAQRLFDNYQTQSEDLEKKHKDSKHVLQVNKLE
                     KEQTLKQRAKNLSQLSEKLGEKHEQIVGLENRVQRMENEKKALLERKLCLESKLLQLK
                     SNAANSKSCQHLQTEISILQEQICHLQFVIHSQHQNLRNIIQEMEGLKNTLKEQDKKI
                     ENLKEKVTVLEAQNEELKTKVAHWTESPRTSVSKAVSTSELKTEGASPYLMLIRLRK"
     misc_feature    <400..>1038
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <400..>1038
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            265..351
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            352..486
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            487..612
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            613..741
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            742..824
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            825..930
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1014
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1091
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1607
                     /gene="Ccdc68"
                     /gene_synonym="RGD1561424"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgggaca ctggactctg ccctgggcgc gcctatctga gcacttaggt gctctcagtc
       61 gccaaacttc agcagttaag gacccgacgg tgggctctct gccagatcgc tggaactgga
      121 gcaggcggag gccttcaaga attcaccatg acaactgtca cggtgaccat ggaagttcct
      181 tctgggggta agacagaaga ccgctccatc ttcagtggac cgtcgtcagc tcagattatt
      241 gaagaaactg agtatgtgag aaagattcga actaccctgg aaaagatccg gaatcgcatg
      301 tttaaggagg aagacggccg aggcaatgca aggcacaaag tagatgcaga gcaatctgga
      361 aatgttcaga atggcttgga ttctacaaca gaccccacca ggttggattt gctcttggaa
      421 agcatgagaa gaaaagatca gcagctccta gaaatgaaca aagaaaacga agtgttgcaa
      481 atcaagctgg aagcttcccg agaagcagga gcggcagctt tgagaaatgc ggctcagaga
      541 ttatttgaca actaccaaac gcagtctgaa gacctggaga aaaagcataa ggacagtaaa
      601 catgtacttc aggtcaacaa actcgagaaa gagcagacgt taaagcaacg tgccaaaaat
      661 ctgagtcaac tttcagaaaa actgggagaa aaacatgagc aaatcgtagg actggaaaac
      721 cgtgtccaga ggatggaaaa tgaaaagaaa gcactcctag agagaaaatt atgtttagaa
      781 agcaagctac tccagctcaa gtccaacgct gcaaattcaa aaagctgcca gcatcttcaa
      841 acggagattt ccatcctcca ggagcagatc tgtcatctgc agttcgtgat ccactcccag
      901 caccagaacc tgcgcaacat catccaggag atggaaggac taaaaaatac tttaaaggaa
      961 caagataaaa aaattgaaaa tttgaaagaa aaggtcaccg tgctcgaagc ccagaatgaa
     1021 gaactaaaaa ccaaggtggc acactggacg gaatctccta ggacatcagt atctaaggcc
     1081 gtctctacaa gtgagttgaa gactgaaggt gcttctccct atttgatgtt gattcggcta
     1141 cgaaaatgag ctggctggct gcagttctga cagagaagga cttctacaga ttttatttat
     1201 tccttgaaat acagtttcag ctcccaagtt aaagtgacat catgtcttat ctaaatgtaa
     1261 cttagtatac atcaataacg gcatagaaag gtgatattgc aggcaattca acaaatgtct
     1321 cctggagaga agaaaccttt ttctttttaa accaaaatgt aacttaaaag gccaagggac
     1381 taggatcttt cccacatgga agatgaattc tgctttaaac ctaaaatatt aaaatttgaa
     1441 tctatctctc ttcaaacatt ttacaaagag gactcttata aggttgtcag atttgacctt
     1501 tgatagtggt tcttatgtgt ataaataaag ggaagtatgt aaatatatat taatgaatga
     1561 tgtaatttaa tttggcattt aggtaataaa tatcttacca tgccaca
//
LOCUS       NM_001437438            2689 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus sialic acid binding Ig-like lectin 5 (Siglec5),
            transcript variant 2, mRNA.
ACCESSION   NM_001437438 XM_006228946
VERSION     NM_001437438.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Tateno,H., Li,H., Schur,M.J., Bovin,N., Crocker,P.R.,
            Wakarchuk,W.W. and Paulson,J.C.
  TITLE     Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F
            reflect roles in cell signaling and innate immunity
  JOURNAL   Mol Cell Biol 27 (16), 5699-5710 (2007)
   PUBMED   17562860
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Zhang,J.Q., Biedermann,B., Nitschke,L. and Crocker,P.R.
  TITLE     The murine inhibitory receptor mSiglec-E is expressed broadly on
            cells of the innate immune system whereas mSiglec-F is restricted
            to eosinophils
  JOURNAL   Eur J Immunol 34 (4), 1175-1184 (2004)
   PUBMED   15048729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006228946.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.2151.1,
                                           SRR26643290.1840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000001.1  102904695-102905022
            329-691             JAXUCZ010000001.1  102905085-102905447
            692-970             JAXUCZ010000001.1  102905601-102905879
            971-1018            JAXUCZ010000001.1  102906048-102906095
            1019-1270           JAXUCZ010000001.1  102908845-102909096
            1271-1573           JAXUCZ010000001.1  102909196-102909498
            1574-1673           JAXUCZ010000001.1  102909773-102909872
            1674-1809           JAXUCZ010000001.1  102910168-102910303
            1810-2689           JAXUCZ010000001.1  102912403-102913282
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2689
                     /gene="Siglec5"
                     /note="sialic acid binding Ig-like lectin 5"
                     /db_xref="GeneID:292843"
                     /db_xref="RGD:1305432"
     exon            1..328
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    247..249
                     /gene="Siglec5"
                     /note="upstream in-frame stop codon"
     CDS             292..2001
                     /gene="Siglec5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 5 isoform 2
                     precursor"
                     /protein_id="NP_001424367.1"
                     /db_xref="GeneID:292843"
                     /db_xref="RGD:1305432"
                     /translation="MLWAQLLPLLWAGSLAVENYELSLTESVTVQEGLCVFVPCQVKY
                     PASGGSVFGYWFQDGANTNLNSPVATNDPHRPVQQETQGRFYLVGGIDTKNCSLDIRD
                     ARKSDTGKYFFRLDGSVKYSFRNRMLSVHVTALTKTPNLQVTSTLVSGTSTRVICSVL
                     WACEQGTPPIFSWMSSALTSLGRRTILSSELNLTPRPQDNGTNLICQVTFPGAGVTVE
                     RTQQLSVTYAPQKLTIRVSWGDGTETKVLQSGASLQIQEGESLRLVCVADSNPSAMLS
                     WKRQTQKNFRLSKGDELQLPRVELEDQGKYICQAKNSLGTQTASVSLSIRSLLQLLAP
                     SCSWDSEGLHCSCSSRAWPAPSLGWRLGEGLLEGNSSNASFTVMSSSAGPWVNSSLSL
                     SVEFSTDHRLSCEAWNDYGVQRATIVLVPGQGVSQADKSETSGGAVQGAIWGAGLMAL
                     LAVSFCLIFFIVKFLRKKSALEVAAMEGNHLAKNLVSTINSASMISSNIPLRYPIQDH
                     LNESESQTQKEEPPLATAPDIPKDEPELHYASLSFQGPRPQQPKNTETIKSVYTEIKI
                     HKR"
     sig_peptide     292..339
                     /gene="Siglec5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    349..690
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    349..690
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    397..411
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    397..411
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    445..459
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    445..459
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    577..591
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    577..591
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    619..636
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    619..636
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    655..675
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    655..675
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    706..960
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    706..960
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    748..762
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409579"
     misc_feature    748..762
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409579"
     misc_feature    799..813
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409579"
     misc_feature    799..813
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409579"
     misc_feature    856..870
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409579"
     misc_feature    856..870
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409579"
     misc_feature    898..915
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409579"
     misc_feature    898..915
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409579"
     misc_feature    943..954
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409579"
     misc_feature    943..954
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409579"
     misc_feature    1045..1266
                     /gene="Siglec5"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    1045..1266
                     /gene="Siglec5"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    1072..1086
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1072..1086
                     /gene="Siglec5"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1111..1134
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1111..1134
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1171..1185
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1171..1185
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1204..1221
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1204..1221
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1249..1260
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1249..1260
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    <1330..1548
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    <1330..1548
                     /gene="Siglec5"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1357..1371
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1357..1371
                     /gene="Siglec5"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1453..1467
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1453..1467
                     /gene="Siglec5"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1492..1509
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1492..1509
                     /gene="Siglec5"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1531..1542
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1531..1542
                     /gene="Siglec5"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            329..691
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            692..970
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1018
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1270
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1573
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1673
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1809
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2689
                     /gene="Siglec5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatgagaaa caaatgcgac agttcaggag cggagggcgg ctcttcctcg ctgactttgg
       61 ctcccatgat gccacacagg aaaagtggaa gtgtttattt tccaagggcc ttgatatcgc
      121 tgataacctg cgggtggaaa gttccttcct tctctgtggt cagtcaccct gcctctcttc
      181 attcctgggc taggtcagta ggacgacttc tcagtcctgt gacattgaag cctatgaccc
      241 tcgaactgac caagttttct gtctctggag cctaggacct ttcactgcgt gatgctgtgg
      301 gcacagctgc tgcccctgct gtgggcaggg tccctggccg tggagaatta tgagctctca
      361 ttgactgaat cagtgacggt gcaggagggt ctgtgcgtct ttgtaccctg ccaagtcaag
      421 taccctgctt ccgggggttc tgtttttggc tactggttcc aggatggggc caacacaaac
      481 ctcaactctc cagtggctac aaatgaccca catcgaccag tacagcagga aactcaaggt
      541 cgtttctatc tcgtgggggg catagatact aaaaattgct ccctggacat cagagacgca
      601 cggaaaagtg acacaggaaa gtacttcttc aggttggatg gaagtgtgaa atacagtttc
      661 cggaatcgga tgctctctgt gcatgtgaca gctctgacta agacccctaa cctccaagtc
      721 acatctaccc tggtgtctgg cacttctacc cgagtgatct gttctgtgct ctgggcctgt
      781 gagcagggga caccccccat cttttcctgg atgtcatctg ccctcacttc cctgggccgc
      841 agaaccatcc tctcctcaga gctgaacctc acacctaggc ctcaggacaa cggcaccaac
      901 ctcatctgtc aggtgacctt ccctggtgct ggtgttactg tggagaggac tcaacagctc
      961 agtgtcacct atgctccaca gaagctgacc atcagggtgt cctggggaga tggcacagaa
     1021 actaaagtcc tgcagagtgg agcatctctg cagatccaag agggtgagtc cctgcgcctg
     1081 gtctgtgtgg cagacagcaa cccctctgcc atgctgagct ggaagcgcca gacccagaag
     1141 aacttccggc tctctaaggg tgatgaactt caactgccac gggtggagtt ggaggaccag
     1201 ggaaaataca tctgccaggc taagaacagt ctgggtactc agacagcctc tgtgagcctc
     1261 agcataagga gccttctaca gctgctggca ccctcctgct cctgggattc tgagggtctg
     1321 cactgcagct gctcctccag agcctggcct gccccgtccc tgggctggcg gctgggggag
     1381 gggctgctgg agggaaacag cagcaatgcc tccttcacag ttatgtccag ctctgcagga
     1441 ccgtgggtca acagctccct gagcctcagt gtggaattca gcactgacca cagactcagc
     1501 tgtgaagctt ggaatgacta tggagttcag agagccacta tcgtgctggt tccaggacaa
     1561 ggagtctcac aggcagacaa atcagaaacc agtggaggag cggttcaggg ggccatctgg
     1621 ggagctggtc ttatggcttt gcttgctgtc tccttctgcc tcatcttctt catagtgaag
     1681 ttcctcagga agaaatcagc attggaagta gcagccatgg aaggcaacca ccttgccaag
     1741 aaccttgtct ccaccataaa tagtgcaagc atgatttcgt ccaacattcc attgagatac
     1801 cccatccagg atcatctgaa tgaatcagag tcacagaccc agaaagaaga gccacctctt
     1861 gccacagccc cagacatccc aaaggatgag cccgaacttc actatgcctc cctctccttc
     1921 caaggtccga ggccccagca gccaaagaac acggagacca tcaagtctgt ttacacagag
     1981 atcaagattc acaagcgctg aagctccttg ccccatgtgt cagtcacagt gctggctgga
     2041 gtcccagaaa ggcatggctg aagatagcat gtgttaggag catattctgg catcagtggc
     2101 cctcttaacc aaaggatatg tagtggaagg agggagtttt ggaaggagag aaggttacag
     2161 agattcctag gttcaaatcc atattcagtg ttattcccag agaagccacc ttttttcttt
     2221 gtgccccctc ttcctcctct gtaaagtgga gtcataatct gaggagtacc aaggagagaa
     2281 tgtgtttatt gttgattata ttgctttatg ttgcctgagc agtggggaag aacgttttgt
     2341 ctttattgca taacttgaat tttacttgta tatttttaaa gaacatatgt tagttcctaa
     2401 agttattctg ttttgaagtg tgactgtgtt gtagctacct gtatctcaga ttggactcat
     2461 tggacattct gcaaactctt aaagatcata cagatatcag cccagactac tatacccagt
     2521 aaaattaaca atcatggggc ataaagctaa tatataaaga tctcccacaa atcaataaaa
     2581 gtgacagaca attcaataca aaatggtaat atgtgagtgg taagcaaaca tacagaaagg
     2641 tgaccaatca gtgcttgtca acgaaatata aataaataca gtacaccta
//
LOCUS       NM_001437459            1082 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus nitric oxide synthase interacting protein
            (Nosip), transcript variant 1, mRNA.
ACCESSION   NM_001437459 XM_006229025
VERSION     NM_001437459.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Yu,X., Zhong,Y., Zhu,Z., Wu,T., Shen,A. and Huang,Y.
  TITLE     Increased expression of nitric oxide synthase interacting protein
            (NOSIP) following traumatic spinal cord injury in rats
  JOURNAL   J Mol Histol 43 (6), 661-668 (2012)
   PUBMED   23135205
  REMARK    GeneRIF: Data suggested that NOSIP may play an important roles in
            astrogliogenesis after a spinal cord injury.
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Dreyer,J., Schleicher,M., Tappe,A., Schilling,K., Kuner,T.,
            Kusumawidijaja,G., Muller-Esterl,W., Oess,S. and Kuner,R.
  TITLE     Nitric oxide synthase (NOS)-interacting protein interacts with
            neuronal NOS and regulates its distribution and activity
  JOURNAL   J Neurosci 24 (46), 10454-10465 (2004)
   PUBMED   15548660
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Dedio,J., Konig,P., Wohlfart,P., Schroeder,C., Kummer,W. and
            Muller-Esterl,W.
  TITLE     NOSIP, a novel modulator of endothelial nitric oxide synthase
            activity
  JOURNAL   FASEB J 15 (1), 79-89 (2001)
   PUBMED   11149895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229025.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216351.1, SRR26643299.2383.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  104679882-104679922
            42-213              JAXUCZ010000001.1  104691442-104691613
            214-319             JAXUCZ010000001.1  104692002-104692107
            320-401             JAXUCZ010000001.1  104692637-104692718
            402-561             JAXUCZ010000001.1  104693880-104694039
            562-680             JAXUCZ010000001.1  104694121-104694239
            681-868             JAXUCZ010000001.1  104694338-104694525
            869-977             JAXUCZ010000001.1  104694601-104694709
            978-1082            JAXUCZ010000001.1  104695015-104695119
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1082
                     /gene="Nosip"
                     /note="nitric oxide synthase interacting protein"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
     exon            1..41
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            42..213
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Nosip"
                     /note="upstream in-frame stop codon"
     CDS             144..1049
                     /gene="Nosip"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="nitric oxide synthase-interacting protein"
                     /protein_id="NP_001424388.1"
                     /db_xref="GeneID:292894"
                     /db_xref="RGD:1309992"
                     /translation="MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFD
                     CCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQMKAYEKQRGARREEQKEL
                     QRAAAQDQVRGFLEKESAIVSRPLNPFMPKAATLPNTDGEQPGPSVGPLGKDKDKALP
                     SFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRS
                     ERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVL
                     QRGGTGFAGSGVKLQAEMSRPVMQA"
     misc_feature    153..377
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    153..377
                     /gene="Nosip"
                     /note="Zinc-finger of nitric oxide synthase-interacting
                     protein; Region: zf-NOSIP; pfam15906"
                     /db_xref="CDD:318178"
     misc_feature    801..1004
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     misc_feature    801..1004
                     /gene="Nosip"
                     /note="U-box domain 2, a modified RING finger, found in
                     nitric oxide synthase-interacting protein (NOSIP) and
                     similar proteins; Region: RING-Ubox2_NOSIP; cd16662"
                     /db_xref="CDD:438324"
     exon            214..319
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            320..401
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            402..561
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            562..680
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            681..868
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            869..977
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1082
                     /gene="Nosip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagttga agcaacgaca ggacggatag tcgtttttga ggcgagttca aaaggcttct
       61 ggagcaggct actgaccaca agcccaggag gtgttcgtgt cctgtgtgag tgaggtcacc
      121 ctgccacttc ccccttggac aagatgacaa ggcatggcaa gaactgcact gcaggggctg
      181 tctacaccta ccacgaaaag aagaaggaca cagcggcctc aggctatggg acccagaaca
      241 ttcgactgag ccgggatgct gtgaaggact ttgactgctg ctgtctctct ctgcagccct
      301 gccatgaccc tgtggtcacc ccagacggct acctgtatga aagggaggca atcctggagt
      361 acatcctaca ccagaagaga gagattgccc ggcagatgaa ggcctatgag aagcagcgag
      421 gagcccggag agaagagcag aaagagctgc agcgagctgc agcacaggac caagttcgag
      481 gcttcctgga gaaggagtca gccattgtga gccggcccct caaccccttc atgcccaagg
      541 ctgccacctt gcccaacaca gatggtgaac agccagggcc cagtgtgggt cccctaggca
      601 aggacaagga caaagcacta cccagcttct ggattccctc actaacgccc gaggcaaagg
      661 ccaccaagct ggaaaagccg tcccgcacgg tgacctgccc gatgtctggg aagccactgc
      721 gcatgtcgga cctgacgtca gtgcgcttca cacagctgga cgactctgtg gaccgagtgg
      781 ggctcatcac gcgcagtgag cgctacgtgt gcgcagtgac ccgagacagc ctgagcaacg
      841 ccacgccgtg tgcggtgctg cggccctccg gggctgtggt caccctggag tgtgtggaga
      901 aactgatccg gaaggacatg gtggaccccg tgaacggaga tacgctgacg gagcgggaca
      961 tcatcgtgct gcagcggggt ggcacaggct ttgcaggctc cggagtgaag ctacaggcag
     1021 aaatgtcccg gccagtgatg caggcctgag ccgtgaccta ataaacttgg acgtgaacag
     1081 gc
//
LOCUS       NM_001437234            3545 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 248 (Tmem248), transcript
            variant 1, mRNA.
ACCESSION   NM_001437234 XM_006249230
VERSION     NM_001437234.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249230.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2197056.1, BC079161.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000012.1  32087200-32087430   c
            232-409             JAXUCZ010000012.1  32079959-32080136   c
            410-695             JAXUCZ010000012.1  32077686-32077971   c
            696-846             JAXUCZ010000012.1  32072686-32072836   c
            847-1030            JAXUCZ010000012.1  32071923-32072106   c
            1031-1174           JAXUCZ010000012.1  32070118-32070261   c
            1175-3545           JAXUCZ010000012.1  32066941-32069311   c
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3545
                     /gene="Tmem248"
                     /note="transmembrane protein 248"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
     exon            1..231
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Tmem248"
                     /note="upstream in-frame stop codon"
     exon            232..409
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1195
                     /gene="Tmem248"
                     /note="UPF0458 protein C7orf42 homolog"
                     /codon_start=1
                     /product="transmembrane protein 248"
                     /protein_id="NP_001424163.1"
                     /db_xref="GeneID:288616"
                     /db_xref="RGD:1303319"
                     /translation="MFSINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIK
                     EIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLSNDTTTPESTMTIGQTRSSTQPPQ
                     SLEESGPINISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITF
                     TLPAAWNADDCALHGHCEQVVFTACMTLTAAPGVFPVTVQPPHCVPDTYSNATLWYKI
                     FTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYF
                     LFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA"
     misc_feature    278..1021
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    278..1021
                     /gene="Tmem248"
                     /note="Transmembrane 219; Region: TMEM219; pfam14940"
                     /db_xref="CDD:464388"
     misc_feature    311..373
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    482..568
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    785..847
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     misc_feature    1058..1120
                     /gene="Tmem248"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY76.1);
                     transmembrane region"
     exon            410..695
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            696..846
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1030
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1174
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..3545
                     /gene="Tmem248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtggttt tctgctttca cccggaaagc ccggcgttcg cagcgcggag ccggcgtccc
       61 gttggcgcgc tctggcctgt cttcaggttg tcgctttcgc cccgaggagc tgctcgctgt
      121 ctccggagcg gcggagagga tggtgcgggg cagtccgggg cccgccgcgc gccgccgcga
      181 gtgaacaggg ccaggccgcg ggcgcccgcg gagccgcggg tctgtggggc ggttgccgct
      241 ggtgagaagc atgttcagca ttaacccctt ggagaacctg aagctgtaca tcagcagccg
      301 gccaccgttg gtggttttta tgatcagtgt cagcgccatg gccatcgcct tcctcaccct
      361 gggctacttc ttcaagatca aggagattaa gtccccagaa atggctgagg attggaatac
      421 tttcctgctc cggtttaatg atttggactt gtgtgtatca gaaaatgaga cactgaagca
      481 tctctccaac gataccacca cacctgagag caccatgacc atcgggcaaa ccagatcgtc
      541 cacccagccg ccccagtccc tggaggagtc aggccccatc aatatttcag tggccattac
      601 cttgaccttg gaccctctca agccctttgg agggtactct cgaaatgtca cacacctgta
      661 ctccaccatc cttggccatc agattggatt gtcaggcagg gaagcccatg aggagatcaa
      721 catcaccttc accctgcctg ctgcctggaa tgccgatgac tgtgctctcc atggccactg
      781 tgagcaggtg gtgttcacag catgcatgac cctcacagct gcccctggag tcttccctgt
      841 caccgttcag ccacctcact gtgtccccga cacatacagc aacgccacac tctggtacaa
      901 gatcttcaca actgccagag atgccaacac gaaatacgct caagactaca accctttctg
      961 gtgttacaag ggcgccattg ggaaagtcta ccacgcttta aatcccaagc tcaccgtcat
     1021 tgtcccagat gacgaccgct ccttaataaa cctgcatctc atgcacacca gttacttcct
     1081 tttcgtgatg gtgataacga tgttctgcta tgcagttatc aaaggcagac ccagcaaact
     1141 gcggcagagc aatcctgaat tttgccctga gaaggtggct ttggctgatg cctaatccca
     1201 cagctcccca ttttctgaga gaccaagaac catgatcatt gcctgctgaa tcggccaggg
     1261 cctggccact ctgtgaatac acgatcttgc aatgttgggt tattccagcc aaagacattt
     1321 caagtgcctg taactgatct gtacatattt ataaacgttg atctggaaac tggtcctgtg
     1381 gtgcacgtgc tttgccctgg atgcggccgg aacccgtcag cctcactgag gggcaggagg
     1441 gcactgacat ggggttcttc catgaagtgc cgggggatgt gggaatcttg ccagagctga
     1501 gcgtgtcgtg ttccaacacc agcggccgag gttggctgcg gttcttgtct cagacggggg
     1561 tgtgcagtgt tggacgctgt gtgcaccttt gtcaggacac tgtttcagaa gccaccattc
     1621 cctcctgcgg ctctcacgtg tctcagtgac catatagcga cagcagtagt tccttctcag
     1681 tttgcttgca aggaaactgt ttttaaaaga gaaaacaagc tacattttat attccccttg
     1741 ttaggacaga caggcttgtc tatccaggtc aaaggtcacg cccccaaggc atttctgtag
     1801 tgaagagcag agttccgtct ccacactggc ccctaggaac tggagtgctt tgctcctctg
     1861 tgctcctggt agagaagttc ctggcttgag aagtggcggt gtaatgggga cacagggcag
     1921 cacaggctgc ctaacttcac aaggcagaag agatggcggg ctgctgtaat gctcacaagc
     1981 agggcttgct ttttttttct ttctaaaatt cgtttcgcat tcatttttgt acatcacaca
     2041 tctatctcca gaaggagaat gaacattata ggtatataat gtggagctgg tgcagggaag
     2101 atctgaagga agaaggcgta tgaggcgctg atggctggcc agtcaaaacc agaagcgttt
     2161 tccttaggac agttgtgacc atccggcccc agtgccctct cgcatttcct ttaggaaagt
     2221 cattcgcatt cccttctgcg agttacttgt atttgcagtg gttttctatc aatgccttgc
     2281 cttaatgccc atgcagtgtt cttccaggca gtgttccaga cttgctgggt gtgaggatga
     2341 atgcatgtta ggagcagccc tctggaggcc gagggaggag aatctcgagt gcgaggctgg
     2401 cctgggccac atactgatag cctgtctcac aggaagaaaa actacttagg tatgtcagca
     2461 cttctgtccc gtaactgtag gtctgtctca gttgcagtta acttgctgta tcccgaacct
     2521 tactggccta gagaatttta tcccaggcat tcttagatgg aaaacaatac tttggatttt
     2581 tgttctaaat tgaagcttgt gaaaataatc actgtagtta ggtgacgccc taatgttttt
     2641 taaagcagag gtgagttact tataagatgg ctaatgtgtg aatttcattt agtcttccct
     2701 tagactttga gagccttgtc aggcaggatg gagaaaaccc acgtggctta gctggtatga
     2761 atgtgtcatc aggaccatca agtttcagat taagtagtaa gacccagtag agtaagacat
     2821 gagaagaaat caccttcatt ggtctgtcgg ctgtgttcct cttagtcatc cttgtgttaa
     2881 tgacaggcag tggctgggat ttgtagaggg tgggaaggag gaacaccata agacctgggg
     2941 agaggaagtc cccaaaatgc ttgagagtga cccatcctga ggccagatac atattttaaa
     3001 gcccaagtat tcgccatagc aggtagacag atggaggatg gctggggaag gaggttgtgg
     3061 gctgagttta ggggactgca gacacatctg ggcctggtcc tcagctgctc cttggtggta
     3121 aacctcaaaa atggcatgtc agattggcca ctagagacct ctgaccccag cagcactggc
     3181 ttgtcctcag gtgtgggtgt gtcagaagtc agtgacttcc tgggaaatgg ttgtttcgga
     3241 tcacattgat ctttcctttt gtctttcacc gtatggtagg acttgaatca gttttgattc
     3301 tgtgtgtacg ttctcttcgt ttggaacctg gcgtttctgt ctgttcttgg cagtgcatag
     3361 gaacccagcc tcctgtattt tgaccctcct gcaggcactg tgggacccaa gggtagcaga
     3421 tccatctccc gtcccttgct gcatgatggt cactagctga tctgtgatgg catccctccc
     3481 tcattgattt tctgtgtttg aagtatgtgc acatgtgctt tacagaataa aacatctgga
     3541 tttac
//
LOCUS       NM_001437436            2812 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase-like 2 (Oasl2),
            transcript variant 2, mRNA.
ACCESSION   NM_001437436 XM_008769327
VERSION     NM_001437436.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Perelygin,A.A., Zharkikh,A.A., Scherbik,S.V. and Brinton,M.A.
  TITLE     The mammalian 2'-5' oligoadenylate synthetase gene family: evidence
            for concerted evolution of paralogous Oas1 genes in Rodentia and
            Artiodactyla
  JOURNAL   J Mol Evol 63 (4), 562-576 (2006)
   PUBMED   17024523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_008769327.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.15980.1,
                                           SRR26643298.81249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840112 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               JAXUCZ010000012.1  47382922-47383219   c
            299-587             JAXUCZ010000012.1  47380276-47380564   c
            588-763             JAXUCZ010000012.1  47379484-47379659   c
            764-1005            JAXUCZ010000012.1  47375682-47375923   c
            1006-1138           JAXUCZ010000012.1  47374360-47374492   c
            1139-2812           JAXUCZ010000012.1  47369829-47371502   c
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2812
                     /gene="Oasl2"
                     /note="2'-5' oligoadenylate synthetase-like 2"
                     /db_xref="GeneID:304549"
                     /db_xref="RGD:1307351"
     exon            1..298
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="Oasl2"
                     /note="upstream in-frame stop codon"
     CDS             101..1612
                     /gene="Oasl2"
                     /EC_number="2.7.7.84"
                     /note="isoform 2 is encoded by transcript variant 2; 54
                     kDa 2'-5'-oligoadenylate synthase-like protein 2"
                     /codon_start=1
                     /product="2'-5'-oligoadenylate synthase-like protein 2
                     isoform 2"
                     /protein_id="NP_001424365.1"
                     /db_xref="GeneID:304549"
                     /db_xref="RGD:1307351"
                     /translation="MDTLPDLYGTVGDSLDYFLEHSLQPQRDWKEEGKDAWERIERFF
                     REKCFCDELLLDQEVRVLKVVKGGSSGKGTALNHRSDQDMILFLSCFSSFKQQARDRK
                     AVIDFIKSKLIHCRKSLAYNITVRQHKEGKRTPRSLTLEIQSRKSNDIICMDILPAYN
                     ALGSFSRDCKPEPEIYENLIRCKGYPGDFSPSFAELQRHFVKSRPVKLKNLLRLVKFW
                     HLKYLRHKYRRAVLPSKYALELLTIYAWEMGTDSSDNFNLDEGFVAVMELLRDYQDIC
                     IYWTKYYDFQNEVVRNFLKEQLKGDRPIILDPADPTNNLGRRGKWELVAKEATYCLLQ
                     LCCVTADRWNVQGARDVQVTVKQTGREEWILLTNPHSPIRKLKAKIKKRMNLCGELRI
                     SFQEPGGERQPLSGRKTLSDYGIFSKVNIRVMETFPPEIQVFVRYPGGQNKPFAIDPD
                     ATILSLWEKIEEDGGPCTEDWVLLFEGEELDDDDNLAELQIKDCDTIQLSRVS"
     misc_feature    185..742
                     /gene="Oasl2"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    185..742
                     /gene="Oasl2"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    order(299..307,314..316,320..328,341..343,347..349,
                     476..481,509..511,560..562,698..700,710..712,719..721)
                     /gene="Oasl2"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(299..307,314..316,320..328,341..343,347..349,
                     476..481,509..511,560..562,698..700,710..712,719..721)
                     /gene="Oasl2"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(302..307,341..343,347..349,479..481,698..700,
                     710..712,719..721)
                     /gene="Oasl2"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(302..307,341..343,347..349,479..481,698..700,
                     710..712,719..721)
                     /gene="Oasl2"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(341..343,347..349,560..562)
                     /gene="Oasl2"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    order(341..343,347..349,560..562)
                     /gene="Oasl2"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    608..1144
                     /gene="Oasl2"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    608..1144
                     /gene="Oasl2"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    1151..1372
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl1_OASL; cd01811"
                     /db_xref="CDD:340509"
     misc_feature    1151..1372
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 1 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl1_OASL; cd01811"
                     /db_xref="CDD:340509"
     misc_feature    1388..1603
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 2 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl2_OASL; cd16103"
                     /db_xref="CDD:340520"
     misc_feature    1388..1603
                     /gene="Oasl2"
                     /note="ubiquitin-like (Ubl) domain 2 found in
                     2'-5'-oligoadenylate synthase-like protein (OASL) and
                     similar proteins; Region: Ubl2_OASL; cd16103"
                     /db_xref="CDD:340520"
     exon            299..587
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..763
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1005
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1138
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..2812
                     /gene="Oasl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtctcct tctccagaga aggctgccgg aagcttctcc cagcattgct gagcagaagc
       61 acagaagatt caatccagag gacaggctga tccagcagag atggatacat tacccgacct
      121 gtatgggacc gttggggaca gtctagacta cttcctggaa cacagccttc agccccaaag
      181 ggactggaaa gaggaaggaa aggatgcctg ggagagaatt gagaggttct ttcgggaaaa
      241 gtgcttctgt gatgagctgc tcctggacca agaagtcagg gtgcttaaag tggtaaaggg
      301 aggctcctca ggaaagggga cggcgctgaa ccacagatct gaccaggaca tgattctgtt
      361 cctgagctgt ttttccagtt tcaaacagca ggcaagagac cggaaggccg tcatagactt
      421 cattaagagc aagctgattc attgtaggaa aagcctggcc tacaacatca ctgtccgtca
      481 acacaaagaa ggcaaaagga cccctcgctc cctgacccta gagatccagt ccaggaagag
      541 caatgacata atttgcatgg atattctccc tgcttacaat gccttgggat ccttttccag
      601 agactgcaaa ccagaacctg aaatctacga gaatctgata aggtgtaagg gctaccctgg
      661 cgacttctcg ccaagtttcg cagagttaca gagacatttt gtgaaaagtc gcccggttaa
      721 actgaaaaac ctcctacggt tggtgaagtt ctggcacctg aagtacctga ggcataaata
      781 tagaagagca gtgttgccct caaaatatgc actggagttg ctgaccatct atgcttggga
      841 gatgggtaca gacagcagtg ataatttcaa tctggatgaa gggtttgtag ccgtcatgga
      901 gctcctcagg gactaccaag acatctgcat ctactggacc aagtactatg atttccaaaa
      961 tgaggtcgtc aggaacttcc tgaaggaaca gcttaagggc gaccggccta tcattctaga
     1021 cccagctgac cccaccaaca acctaggaag aagaggaaaa tgggaactgg tggccaaaga
     1081 agctacttac tgcctgctac agttgtgttg tgtgactgca gaccgctgga atgttcaggg
     1141 agcgagggac gttcaggtga cagtgaaaca aacaggaagg gaagagtgga ttctcttgac
     1201 aaacccccac agccccatca ggaagttgaa ggcaaagatc aagaagagaa tgaacctctg
     1261 tggggagctg cgtatctcct tccaggagcc gggaggggag aggcagccgc tgagtggccg
     1321 gaaaaccctg tcggattatg gaattttctc taaggtgaac atccgggtga tggagacctt
     1381 tcctcctgag atccaggtct ttgtgaggta tcccggtggc cagaacaagc cttttgccat
     1441 cgaccctgat gctaccatct taagcctgtg ggagaaaatt gaggaagatg gaggcccatg
     1501 tacggaggat tgggtactac tgtttgaggg tgaggagctg gacgatgatg acaaccttgc
     1561 agagcttcag atcaaggact gtgacaccat ccagctcagc agggtctcct agtctgcctc
     1621 cccacatcac ccctttactc tgacatattc ctcctgtagc ttaaacatca tcatatccgg
     1681 ttggggattt ggctcagtgg tagagcgctt gcctagcaac cgcaaggccc tgggttcggt
     1741 ccccagctcc gaaaaaaaaa gaaaaaacaa aacaaaacag aacaaaaaaa tcatcatatc
     1801 cttctcttgc ttaaaaccct cctgtgtttt ctggtaacac agggtgaagt tcaagtttct
     1861 tttcctaaca agagtcttaa atataatccc ccacccccac cctgcacact caatgcacac
     1921 cagatactga atgaccccgt gagtcacaca cagagttccg agggctcccg agtcccagcg
     1981 agttcgggtc acactgagtg caaatgacac acacaaaggg gctggggtca cgcccccatc
     2041 actttgcctc aactaccctt tccctcaccc cagcctgtgt tctcatcgtt ctgtgagata
     2101 ccgaatctca aagagcagac ctcagatgga cagatttctc acctctccag aaacgtctca
     2161 gaaggaaaaa ctaacctgaa ccagggaccc gctgggactc agcgggctct gagccttcca
     2221 tgtcatccgg caagcttgag tttgaaaaca acaacctccc tcgtggttgg ggatttagct
     2281 cagcggtaga gcgcttgcct agcgagtgca aggccctggg ttcggtcccc agctctggaa
     2341 aaaaaaaata ataacaaaaa aacctcgggc tggagagatg gctcaacggt taagagcacc
     2401 cgactgctct tccagaggtc atgagttcaa ttcccagcaa ccgcatggtg gctcacaacc
     2461 atctataaag agatccgatg ccctcttctg gtgtatctga agacagctac agtgtactta
     2521 tatataataa ataaataaat cttaaaaaaa aaaaaagaaa gaaagaaaaa gaaaacaact
     2581 acttctggcc catgcaacag gccatgtgat cttgtgttct cgccctctcc catcatcccc
     2641 attagactcc tgggaatgtg ggaccttaat catgctgttt tcctaatcta tctccctcat
     2701 ctaatgagac ttgattgttt ttttaatgcc ttaggccttg tgctctacaa ggataccagt
     2761 ccagtacaaa tgtttgattt ctgctggtta aataaagaaa ctaaccaaag aa
//
LOCUS       NM_001005882            4828 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus RNA binding motif protein 47 (Rbm47), transcript
            variant 1, mRNA.
ACCESSION   NM_001005882 XM_006250951 XM_223403
VERSION     NM_001005882.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4828)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   2  (bases 1 to 4828)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 4828)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4828)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 26, 2025 this sequence version replaced
            XM_006250951.4, NM_001005882.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.952959.1,
                                           SRR26360176.619287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000014.1  42407277-42407378
            103-259             JAXUCZ010000014.1  42407538-42407694
            260-340             JAXUCZ010000014.1  42466335-42466415
            341-460             JAXUCZ010000014.1  42515618-42515737
            461-1620            JAXUCZ010000014.1  42535100-42536259
            1621-1827           JAXUCZ010000014.1  42537071-42537277
            1828-2033           JAXUCZ010000014.1  42539399-42539604
            2034-4828           JAXUCZ010000014.1  42542510-42545304
FEATURES             Location/Qualifiers
     source          1..4828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4828
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="RNA binding motif protein 47"
                     /db_xref="GeneID:305340"
                     /db_xref="RGD:1359713"
     exon            1..102
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            103..259
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            260..340
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            341..460
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="upstream in-frame stop codon"
     exon            461..1620
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..2264
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="hypothetical RNA binding protein RGD1359713"
                     /codon_start=1
                     /product="RNA-binding protein 47"
                     /protein_id="NP_001005882.1"
                     /db_xref="GeneID:305340"
                     /db_xref="RGD:1359713"
                     /translation="MTAEDSTTAMNSDPTVGSSTKVPEGVAGAPNEAALLALMERTGY
                     NMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRL
                     MMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPK
                     MKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGR
                     IQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKRSFGQFNPGCVER
                     VKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGG
                     GGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRT
                     PGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISAVNPVAIKPGTVAIPA
                     IGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVS
                     TPPPFQGRPITPVYTVAPNVPRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGG
                     YAGYIPQAFPAALQVPIHDVYQTY"
     misc_feature    492..569
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66H68.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    522..2261
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    522..2261
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; Region: hnRNP-R-Q; TIGR01648"
                     /db_xref="CDD:273732"
     misc_feature    1677..1679
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96; propagated from
                     UniProtKB/Swiss-Prot (Q66H68.1); methylation site"
     misc_feature    1710..1712
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:A0AV96; propagated from
                     UniProtKB/Swiss-Prot (Q66H68.1); methylation site"
     exon            1621..1827
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2033
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..4828
                     /gene="Rbm47"
                     /gene_synonym="RGD1359713"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttagtcac agaattcgat tcctgttggc tgattcggcg cctgcaaaca ggcttagtgc
       61 tccattgaaa tgcgggaggc tccttaattc ttgtataaac agaaaccagc tgtaacacta
      121 ggtcagagcg ctttaagaat gagccacttt gaacaagcgg cgcccaggcc ccaggccctg
      181 ctgtgaaggc cccggcaaag gtcagagctc ggccccgtga cgtgcctgcc tgtgttctcc
      241 gagccatgct cagcctcagc tcaggtaaca aacaagttag aaggacagcc tgcgccctgc
      301 cacccagcct cactagcagc tcccagctca ctgaagtttg ggtttgcctc aaagaatact
      361 tcaagaactg aacagagaaa tcccaagtga gctgcctgaa tcttcgcgaa ttctcttgtt
      421 ctaccttcca tagaaagacc aatcaaattg ctgacttttg gtttcctcca gctgtggatg
      481 cctttgacat tatgactgca gaagattcca ccacagccat gaacagcgat ccaacagtgg
      541 ggtcctccac caaggtaccg gagggtgtgg cgggcgcgcc caatgaggct gcactgttgg
      601 cactgatgga gcgcaccggt tacaacatgg tacaggagaa tgggcagcgc aagtatggtg
      661 gacccccgcc cggctgggag ggcccgcatc cccagcgtgg ctgtgaggtc ttcgtgggca
      721 agatcccacg tgatgtgtat gaagatgagc tggtgcctgt gtttgagacg gtaggtcgca
      781 tctacgagct gcgcctcatg atggatttcg atggcaagaa ccgcggctat gccttcgtga
      841 tgtactgcca caagcacgag gccaagcgag ctgtccgtga gctcaacaac tatgagatcc
      901 gcccgggtcg tctgctggga gtgtgctgca gtgtggacaa ctgccgcctc ttcatcggtg
      961 gcatccccaa gatgaagaag cgtggggaga tcctggagga gatcgccaag gtcaccgagg
     1021 gcgtgctcaa cgtgattgtg tatgccagtg cagcagacaa gatgaaaaac cgaggcttcg
     1081 cctttgtgga atatgagagc catcgggccg cagcaatggc ccgtcgcaag ctcatgccgg
     1141 gtcgtatcca gctgtggggc caccagatag ccgtggactg ggccgagcca gagattgatg
     1201 tagatgagga tgtgatgcag accgtgaaga tcctctacgt gcgcaacctc atgatcgaga
     1261 ccaccgagga gaccatcaag aggagctttg gccagttcaa cccaggctgt gtggaaagag
     1321 tcaagaagat ccgtgactac gccttcgtgc acttcactag ccgcgaggac gctgtgcacg
     1381 ctatgaacaa cctcaatggc acagagctgg agggctcctg cttagaagtc acgctggcca
     1441 agcctgtgga caaggagcag tactctcgct accagaaggc agccaagggt ggcggtggct
     1501 cagctgaggc agtggcacaa cagcccagct acgtgtactc ctgtgacccc tacacgctgg
     1561 cctattatgg ctacccctac aacgcgctca tcgggcccaa ccgggactac ttcgtgaaaa
     1621 caggcagcat aagaggccga ggacgcggtg cagctgggaa cagaaccccg gggcccaggg
     1681 gttcctacct gggagggtat tctgccggcc gtggcatata tagccgatat cacgaaggca
     1741 agggcaaaca gcaggagaaa ggatacgagc tcgtgccgaa cctggaaatc tctgccgtca
     1801 acccagtggc catcaaacct ggcacagtgg ccatccctgc cattggtgcc cagtactcca
     1861 tgttccaggc agccccggcc cctaaaataa ttgaagatgg caagatccac acaatggaac
     1921 acatgatcag ccccattgcg gtgcagccag acccggccac tgctgctgcc gccgccgctg
     1981 ccgctgctgc tgctgctgtc attcctgcgg tatccacacc gccgcctttc cagggccgtc
     2041 caataactcc tgtgtacact gtggcaccaa atgttccgag aatccccacc gccggcatct
     2101 acggggccag ctatgtcccc tttgctgctc cggccactgc cacaatcgcc acactacaga
     2161 agaacgctgc agccgccgtg tacgggggct acgcgggcta catacctcag gccttccctg
     2221 ctgctctcca ggtgcccatc cacgacgtct accagactta ctgagaccgg ggaccagaaa
     2281 ggcaagccac caaaccccgc cgaaggaaca ctctattatt tatgaagaaa gaacgtgtcg
     2341 ggttgacaca cgtgtaaaac ctgcaagtga agaagaatgt tatcaaatag cacactgaaa
     2401 tattttatat ccatgaagtt ttcactcatg tttttttgaa aatgactttt caatttagca
     2461 ggcccgcgtt catacatttc taagagactt gcgacgcctc atgccttaac atcatctttt
     2521 aaagtttgta tgctctactg tgtttgtaca gaggtttggt tttgtttttt aaggatatat
     2581 tttcagtatg aaggttattt tcttaacttc tgcactccag agttttctat tttgtagaac
     2641 ctttcaaaat atatcagctc tctctatata tatgtatatg tatatccaaa aaaaaaaaaa
     2701 aaaagagcac gcccgggcat ctagggaact attttgaaaa ctatattcaa tatttaaaga
     2761 cacaaactgt agtgttctga aatgctacgc aaaacatttt atttttaagg tgatgctgga
     2821 aagtgcaatt ttaaaatgag gaaaaaaagg tctctactgt gtttctactg gcattaaggg
     2881 ttgacgatat tgccatatat tcttgtcatg ttttctgggt ttatgggggt ttgggtttgg
     2941 tttgtttgtt tgtttgtttg ttttaataag tctgttctta agccaacatg gaaaagactc
     3001 cccacaccca gagtcccaac actggaaagc tctgacctgc cctcagtacc ctgggctcac
     3061 cctgtgtctc tactgttatc tgccccgccc caccctcaag gagggattct gcctccttcc
     3121 ctggctcccg ggcagctctg aggtttggca tatctaagaa aagtggataa tcgaatggag
     3181 aggactactg atgcctttta tgcttcttcc tgggattgtg ttggggtctt tttatattta
     3241 attttggatt gtctggggat gtattttctt ctccatgtgt tttcagtagc agaatgcacc
     3301 cgagggcaag attttacctc gtttgcctaa ggcatctttg catagctatt tgttcagtac
     3361 ggaacttcaa ctttctaatc ctttgttttt ttggcgtgtt tttttttttt ttaagtctga
     3421 gtttttagag accaagaatg tatgtgacta tagacaagac cttcaagact tgtcaacagg
     3481 aagtttagct tctcgctgcc tttctgcgtt tcctacagga tgcctgttgt catcagggat
     3541 gttagaagca ctgtgtgtgt ttaacagggt ttctctcagc cgccctgcgt ttggtaggcg
     3601 aacagggggc atacccatcc aagaggagga cctgtaggtt aagggtagtt tgtaaataac
     3661 ttctgatgct tgctcataca caccttctgt gttgccaaag ctcgtggctt gtagtgtaat
     3721 gcgaaacgca gccattttat ttcaatgtta ttaaaagtgt ttgctttttt gtgggggggg
     3781 gagtaaatgc acagaggcag ggttagggtt ttgtgcctgt tttaaggctt ttatttggca
     3841 gtgaatgtaa aatacagtga aatgataata ttgtcatctc ttttatgaat tacatctttt
     3901 taaaaggctt ggtccagggt gtgaagtgag cgataaggta acagaggcat ggttgtattt
     3961 tatggcataa cagagtccat cagatttttc ttccctccag agttttgcta ataggcttaa
     4021 ctcttatttc tggattaata gtaggatcat gcccttagca aataattttc tgtttttaaa
     4081 ttaagagatt cccaaatgtc ttttcccccc cttatcttga tgggatggat tttatatata
     4141 agaaatattt atttagctat tctgtaaaat tatctagtgc ctgctaaggc ctttgagcat
     4201 ccctccatcc tgttgcgtgg cataaagcag cagctgtacg gtgttctggg ggctcactca
     4261 gaagctgcac ccactcgggc ccgtggggat gagggacctt atcaaaggta tcaggttctc
     4321 atcccttgac ttgtgtgagg aaaaaagtgc tttccttcct gccaccacgg actgacatgg
     4381 aagtcttcag atggaacgct gaccccatgt tcttactgta tttttcaagt gcctggaaaa
     4441 aaatattttc aaaaacaata ctagtaataa taaaaggaaa aaatatgcac taacttaaca
     4501 tggcaactac cttaacaaca ggcattggtg gcagccagtt aagcaccagt ggccctgctg
     4561 tctgtgatct tacctgttcc tcttgtttct caaccatttc acacgtacac tactgaggta
     4621 agtttataac ttgaaatgtg aacttttttt ttttttagga ataagaacaa actaatataa
     4681 atgtttttaa acgttttaga gtttgggttt tagacatgct actagtttag tttttagctt
     4741 catatttgaa aagcttttta gatctcgctt catttacata cagtgcattc ttaaaatgta
     4801 tgtggtaaat aaagctttct tgaaagca
//
LOCUS       NM_001009491            1705 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus 2 ' -5 ' oligoadenylate synthetase 1H (Oas1h),
            mRNA.
ACCESSION   NM_001009491 XM_579292
VERSION     NM_001009491.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001009491.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY196701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840112,
                                           SAMN16418971 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000012.1  41353781-41353991   c
            212-500             JAXUCZ010000012.1  41352568-41352856   c
            501-697             JAXUCZ010000012.1  41349880-41350076   c
            698-933             JAXUCZ010000012.1  41346806-41347041   c
            934-1087            JAXUCZ010000012.1  41345987-41346140   c
            1088-1705           JAXUCZ010000012.1  41344320-41344937   c
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1705
                     /gene="Oas1h"
                     /note="2 ' -5 ' oligoadenylate synthetase 1H"
                     /db_xref="GeneID:494200"
                     /db_xref="RGD:1359732"
     exon            1..211
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1117
                     /gene="Oas1h"
                     /note="2'-5' oligoadenylate synthetase 1H"
                     /codon_start=1
                     /product="2 ' -5 ' oligoadenylate synthetase 1H"
                     /protein_id="NP_001009491.1"
                     /db_xref="GeneID:494200"
                     /db_xref="RGD:1359732"
                     /translation="MEKDLKSTPAWKLDKFIQNHLLADTTFVTEAKADIEFLCDFLTE
                     RCFQDASHPVRVSRIVMGGCYDEYSMLKGRSEATLVVFFNNLTRFEDQLKRREELIEE
                     IWKHLCQLQHEKQFKLKFEVQSSEQDNYSSLSIKLSSPQLQQEVEFDVQPAYDVLYEL
                     KEKLELDCEFYNKIYARLIRECITLRKEGEFSVCFMELQQKFLWNRPEDLRNLLVLVK
                     HWYQLCKEKLGDSLPPQYALELLTVHAWENEIPAKYGAQTARGFQSVLELIIKYTCLR
                     VYWTFYYDILHQDVSSYLHKQLRKERPVILDPADPTRNVAGLNIDGWCELAKEAEAWL
                     KYPCFRHIDETFVGSWEVPPEKQGGVFL"
     misc_feature    113..>499
                     /gene="Oas1h"
                     /note="Nucleotidyltransferase (NT) domain of DNA
                     polymerase beta and similar proteins; Region:
                     NT_Pol-beta-like; cl11966"
                     /db_xref="CDD:472251"
     misc_feature    113..>499
                     /gene="Oas1h"
                     /note="Nucleotidyltransferase (NT) domain of DNA
                     polymerase beta and similar proteins; Region:
                     NT_Pol-beta-like; cl11966"
                     /db_xref="CDD:472251"
     misc_feature    order(254..256,260..262,473..475)
                     /gene="Oas1h"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143387"
     misc_feature    order(254..256,260..262,473..475)
                     /gene="Oas1h"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143387"
     misc_feature    545..1093
                     /gene="Oas1h"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    545..1093
                     /gene="Oas1h"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     exon            212..500
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            501..697
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            698..933
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1087
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1705
                     /gene="Oas1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcagca aacattcctg gcctcaggat ggagaaggat ctcaagagta ctccagcttg
       61 gaagctggac aagttcatac agaatcacct ccttgctgac accaccttcg ttactgaggc
      121 caaggcagac atagagttcc tatgtgattt cctgactgag agatgcttcc aagatgcctc
      181 ccaccctgtg agggtctcta ggattgtgat gggcggctgc tatgatgaat actccatgct
      241 caagggaagg tcagaggcca ccctggtggt gttctttaac aatctcacca gatttgagga
      301 tcagttaaag cgacgggaag agctcattga agaaatttgg aaacacctgt gccagttgca
      361 gcacgagaaa cagtttaaac tgaagtttga ggtccagagc tcagagcagg acaactacag
      421 ctctctgagc atcaagctga gctcgcccca gctccagcag gaggtggagt ttgatgtgca
      481 gccagcctat gatgtcctgt atgaactgaa agaaaaactg gagcttgact gtgagttcta
      541 caacaaaatc tatgcccggc tcatccgtga gtgcatcacc ctgaggaagg agggcgagtt
      601 ctccgtctgc ttcatggagc tccagcaaaa gttcctgtgg aatcgtccag aagacctgag
      661 gaatctcctc gtactggtca agcactggta tcaactgtgt aaggagaagc tgggggattc
      721 gctgccccca cagtacgccc tggagctgct cacggtccat gcctgggaaa acgaaattcc
      781 agccaaatat ggagcacaga cagctcgggg tttccagagt gtcttagaac tgatcattaa
      841 gtacacctgt cttcgagtct actggacatt ttattacgac attctacacc aggatgtctc
      901 cagctacctg cacaaacagc tccgtaaaga aaggcctgtg atcctggacc ctgctgaccc
      961 aacaaggaac gtggctggtt tgaacataga tggctggtgt gagctggcaa aagaggcaga
     1021 agcctggctg aagtacccgt gctttaggca catcgatgag acctttgtgg gctcctggga
     1081 agtgccgcca gagaaacaag gaggtgtctt cctgtgagca ccacagccct tgcccaggag
     1141 gctctggagt caggggcatt cactcctctg ctgcaagacc ttgtcctgca gagaacagtt
     1201 tggtacacca ggctccagtg aggggcatcc aacctgtgat cagactctag gcttctgatc
     1261 ccgtcctgcc catgggacag ccttcctcac agcctgcttc acctgcctta tcctccacag
     1321 tgctctctgg gagtcagact ccgaaggaaa gagaagagct caaacttggc ttctgtctgt
     1381 ccacctgtgg ggaggctctg tccacaaaca tgtctgatca tgaacaattg accacagcaa
     1441 tccctgaggg agtgtgcact cggaggggtg agtcctcagc ccacatagga acggctcagc
     1501 agaggagcgt ggcccggaac gctggggatc tggccagtgt gcatcaaggt gcactgttgg
     1561 gcaaagtgtg agctggggtt acggcagtgc agggaaataa gattatgtac actttaaaac
     1621 ttaggacctt aaaacgtatg tgtgtgcatg tgaggatgag atttgaagcc ctgaattaaa
     1681 gtaaaatgca aaggactaaa ctaaa
//
LOCUS       NM_001437294             847 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437294
VERSION     NM_001437294.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 847)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 847)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.1560042.1,
                                           SRR26360190.1613304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000011.1  44781238-44781317
            81-216              JAXUCZ010000011.1  44781568-44781703
            217-356             JAXUCZ010000011.1  44823304-44823443
            357-847             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..847
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..80
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    40..42
                     /gene="Mrps6"
                     /note="upstream in-frame stop codon"
     exon            81..216
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..549
                     /gene="Mrps6"
                     /note="isoform 1 is encoded by transcript variant 1; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 1"
                     /protein_id="NP_001424223.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MPRYELALILKAMRRPETAAALKRTIESLMDRGAIVRNLENLGE
                     RALPYRISSHSQQHSRGGYFLVDFYAPTNAVESMLEHLARDTDVVRPNIVKHPLTQEV
                     KECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    178..459
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    178..459
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(181..183,316..318,328..330,385..387,394..399,
                     418..420,439..441,448..456)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(181..183,316..318,328..330,385..387,394..399,
                     418..420,439..441,448..456)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(184..186,190..192,304..306,310..318,358..360,
                     364..366,439..441,451..453)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(184..186,190..192,304..306,310..318,358..360,
                     364..366,439..441,451..453)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     exon            217..356
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            357..847
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggagagg gaggaggcct ggaaagttcc actggtttct agagcccaag gttggtcggc
       61 gcggaggcgg cgcgcagcgg ggagcctacc ggctgcatct cctctcgtct tccactgcac
      121 ccggcgtttc ccgacctagc gaccccggac tcggtgccgc catcccgggc gatgccccgc
      181 tacgagttgg ctttgattct gaaagccatg cggcggccag agaccgctgc tgctttaaaa
      241 cgtacaatag aatccctgat ggaccgagga gccatagtga ggaacttgga aaacctgggt
      301 gagcgtgcac tcccatacag gatctccagt cacagccagc agcacagccg aggagggtat
      361 ttcttggtgg atttttatgc cccaacaaat gctgtggaaa gcatgctgga acacttggca
      421 cgagacactg atgtggttag accaaatatt gtgaaacacc ctctgaccca ggaagtaaaa
      481 gagtgtgacg gcatagtccc agtccctctt gaagaaaaac tgtattcaac aaagagaagg
      541 aagaagtgag aagattcacc agatgtggct atgttcaatt ctaagtgcac catgggtgct
      601 gataggtttg tctaggatgc tttagcccgt gaccattttg ctgcagatgg ggactgctgg
      661 ccgagacctg ctctgtcacc cctgctgata tttcaccctc actgtgtgat tgtcagggtg
      721 cggtggggct ggtgttcaca gtcccactgc agagtttcga agaacaaaat gtttgtcatt
      781 cacactcggt tgtcttgtaa acctgtgtgg aacacagagc agagtaataa acatggtttt
      841 atcaaca
//
LOCUS       NM_001106184            2907 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus WW domain containing E3 ubiquitin protein ligase
            2 (Wwp2), mRNA.
ACCESSION   NM_001106184 XM_001076615 XM_214669
VERSION     NM_001106184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Yang,C., Pan,J., Luo,X., Li,J. and Jiang,Z.
  TITLE     Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast
            proliferation by regulating the WWP2/Notch1 axis
  JOURNAL   Regen Med 17 (6), 375-388 (2022)
   PUBMED   35545948
  REMARK    GeneRIF: Hypoxia-induced mesenchymal stem cells inhibit corneal
            fibroblast proliferation by regulating the WWP2/Notch1 axis.
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Yuan,L., Lv,Y., Li,H., Gao,H., Song,S., Zhang,Y., Xing,G., Kong,X.,
            Wang,L., Li,Y., Zhou,T., Gao,D., Xiao,Z.X., Yin,Y., Wei,W., He,F.
            and Zhang,L.
  TITLE     Deubiquitylase OTUD3 regulates PTEN stability and suppresses
            tumorigenesis
  JOURNAL   Nat Cell Biol 17 (9), 1169-1181 (2015)
   PUBMED   26280536
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Nabhan,J.F., Hu,R., Oh,R.S., Cohen,S.N. and Lu,Q.
  TITLE     Formation and release of arrestin domain-containing protein
            1-mediated microvesicles (ARMMs) at plasma membrane by recruitment
            of TSG101 protein
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4146-4151 (2012)
   PUBMED   22315426
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Nakamura,Y., Yamamoto,K., He,X., Otsuki,B., Kim,Y., Murao,H.,
            Soeda,T., Tsumaki,N., Deng,J.M., Zhang,Z., Behringer,R.R.,
            Crombrugghe,Bd., Postlethwait,J.H., Warman,M.L., Nakamura,T. and
            Akiyama,H.
  TITLE     Wwp2 is essential for palatogenesis mediated by the interaction
            between Sox9 and mediator subunit 25
  JOURNAL   Nat Commun 2, 251 (2011)
   PUBMED   21427722
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Chen,A., Gao,B., Zhang,J., McEwen,T., Ye,S.Q., Zhang,D. and Fang,D.
  TITLE     The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced
            T-cell death by catalyzing EGR2 ubiquitination
  JOURNAL   Mol Cell Biol 29 (19), 5348-5356 (2009)
   PUBMED   19651900
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Xu,H., Wang,W., Li,C., Yu,H., Yang,A., Wang,B. and Jin,Y.
  TITLE     WWP2 promotes degradation of transcription factor OCT4 in human
            embryonic stem cells
  JOURNAL   Cell Res 19 (5), 561-573 (2009)
   PUBMED   19274063
  REMARK    Erratum:[Cell Res. 2009 Jun;19(6):796]
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Foot,N.J., Dalton,H.E., Shearwin-Whyatt,L.M., Dorstyn,L., Tan,S.S.,
            Yang,B. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter DMT1 and iron
            homeostasis by a ubiquitin-dependent mechanism involving Ndfips and
            WWP2
  JOURNAL   Blood 112 (10), 4268-4275 (2008)
   PUBMED   18776082
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Jespersen,T., Membrez,M., Nicolas,C.S., Pitard,B., Staub,O.,
            Olesen,S.P., Baro,I. and Abriel,H.
  TITLE     The KCNQ1 potassium channel is down-regulated by ubiquitylating
            enzymes of the Nedd4/Nedd4-like family
  JOURNAL   Cardiovasc Res 74 (1), 64-74 (2007)
   PUBMED   17289006
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Xu,H.M., Liao,B., Zhang,Q.J., Wang,B.B., Li,H., Zhong,X.M.,
            Sheng,H.Z., Zhao,Y.X., Zhao,Y.M. and Jin,Y.
  TITLE     Wwp2, an E3 ubiquitin ligase that targets transcription factor
            Oct-4 for ubiquitination
  JOURNAL   J Biol Chem 279 (22), 23495-23503 (2004)
   PUBMED   15047715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076615.1, XM_214669.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2907
                     /gene="Wwp2"
                     /note="WW domain containing E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:291999"
                     /db_xref="RGD:1310091"
     exon            1..65
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    39..41
                     /gene="Wwp2"
                     /note="upstream in-frame stop codon"
     exon            66..150
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2693
                     /gene="Wwp2"
                     /EC_number="2.3.2.26"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP2"
                     /protein_id="NP_001099654.1"
                     /db_xref="GeneID:291999"
                     /db_xref="RGD:1310091"
                     /translation="MASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEV
                     AVDGLPSETKKTGKRIGSSELLWNEVIVLNVTAQSHLDLKVWSCHTLRNELLGTASVN
                     LSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDG
                     SQPPSRESSGTALAPETRHQPPSTNCFGGRSRTHRHSGGSARTATATGEQSPGARNRH
                     RQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSPPAAASSVSPNPNTTSLPAPS
                     TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWERPLPP
                     GWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLY
                     QSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGW
                     EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYERSFRWKYHQFRFLCHS
                     NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL
                     LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDT
                     GFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIKENNLDECGLELFFIQDMEILGKV
                     TTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF
                     DEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFV
                     TGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEK
                     LLYAIEETEGFGQE"
     misc_feature    129..506
                     /gene="Wwp2"
                     /note="C2 domain present in E3 ubiquitin ligase; Region:
                     C2_E3_ubiquitin_ligase; cd04021"
                     /db_xref="CDD:175988"
     misc_feature    129..506
                     /gene="Wwp2"
                     /note="C2 domain present in E3 ubiquitin ligase; Region:
                     C2_E3_ubiquitin_ligase; cd04021"
                     /db_xref="CDD:175988"
     misc_feature    <567..1016
                     /gene="Wwp2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <567..1016
                     /gene="Wwp2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    984..1073
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    984..1073
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    1074..1163
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    1074..1163
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    1299..1385
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    1299..1385
                     /gene="Wwp2"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    1419..1511
                     /gene="Wwp2"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; Region: WW; cd00201"
                     /db_xref="CDD:238122"
     misc_feature    1419..1511
                     /gene="Wwp2"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; Region: WW; cd00201"
                     /db_xref="CDD:238122"
     misc_feature    order(1461..1463,1494..1496)
                     /gene="Wwp2"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     misc_feature    order(1461..1463,1494..1496)
                     /gene="Wwp2"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     misc_feature    1626..2684
                     /gene="Wwp2"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; Region: HECTc;
                     cd00078"
                     /db_xref="CDD:238033"
     misc_feature    1626..2684
                     /gene="Wwp2"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; Region: HECTc;
                     cd00078"
                     /db_xref="CDD:238033"
     misc_feature    order(1641..1643,1731..1733,1764..1766,1947..1949,
                     2469..2471,2574..2579,2586..2600,2658..2660,2679..2681)
                     /gene="Wwp2"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     misc_feature    order(1641..1643,1731..1733,1764..1766,1947..1949,
                     2469..2471,2574..2579,2586..2600,2658..2660,2679..2681)
                     /gene="Wwp2"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     misc_feature    order(2031..2033,2040..2045,2049..2054,2061..2063,
                     2082..2084,2088..2090,2097..2102,2106..2108,2124..2126,
                     2139..2141,2190..2192,2202..2204)
                     /gene="Wwp2"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     misc_feature    order(2031..2033,2040..2045,2049..2054,2061..2063,
                     2082..2084,2088..2090,2097..2102,2106..2108,2124..2126,
                     2139..2141,2190..2192,2202..2204)
                     /gene="Wwp2"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     exon            151..298
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..420
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..558
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..655
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..783
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..994
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1084
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1259
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1314
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1396
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1525
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1601
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1673
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1762
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1922
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2056
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2197
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2318
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2423
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2520
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2593
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2907
                     /gene="Wwp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagtgcgg gcgctggaag gcggaagtgg agcggagtta ggcgccgctg gtgtggccgc
       61 ggcagttcca ttgtgatgat atggcgtctg ccagctccag ccgggcgggg gtggccctgc
      121 cttttgagaa gtcccagctt actctgagag tggtgtcagc aaagcccaag gtgcacaacc
      181 gccagcccag aatcaactcc tatgtggagg tggcagtgga tggactcccc agtgagacca
      241 agaagactgg gaagcgcatc gggagctctg agcttctctg gaatgaagtc atcgttctga
      301 atgttacagc ccagagtcat ttagatttga aggtctggag ctgtcatacc ttgaggaatg
      361 aactactggg cactgcctct gtcaacctct ccaatgtcct gaagaacaat ggcggcaaaa
      421 tggagaacac gcaactgacc ctgaacctgc agacagagaa caaaggcagc gttgtctcag
      481 gaggagagct gacaattttc ctggatgggc caactgttga tctgggcagt gtgcctaatg
      541 gcagtgcagt gacagacgga tcacaaccac cttcaagaga atccagtggg actgctctag
      601 ctccagagac ccggcaccag ccccccagta caaactgctt tggtggcaga tcccggacgc
      661 acagacattc aggtggctca gccaggacag ccacagcaac tggcgaacaa agtcctggtg
      721 ctaggaaccg ccaccgccaa cctgtgaaga accccagcag cagtggctta gccaatggca
      781 cagtgagtga ggaacctacg acagccagcg atcctgaaga actgtcggtt gttggtgtga
      841 catcgccgcc tgctgcagcc tccagtgtgt ccccaaatcc caacacgaca tctctccctg
      901 caccgtccac accagctgag ggagaagagc ccagcacttc cgggacacag cagctccctg
      961 ctgctgccca ggcccctgat gctcttcctg ctggatggga acagagacag ctgcccaatg
     1021 ggcgtgtcta ttatgttgat cacaatacca agaccaccac ctgggagcgg cctcttcctc
     1081 caggatggga aaagcgcaca gacccccgag ggaggtttta ctacgtggac cacaacaccc
     1141 ggacaaccac ctggcagcgc ccgactgctg agtacgtgcg gaactatgag cagtggcagt
     1201 cacagcggaa tcagctgcag ggggccatgc agcacttcag ccaaagattc ctctaccagt
     1261 cttcgagtgc ttcgactgac catgatccct tgggccccct cccgcctggc tgggagaaga
     1321 ggcaggacaa tggccgggtg tattacgtga accacaacac acgcactacc caatgggagg
     1381 acccgcggac gcagggaatg atacaggagc cagccctgcc cccagggtgg gagatgaagt
     1441 acaccagcga gggcgtgcgg tactttgtgg atcacaacac ccgcactacc acctttaagg
     1501 atcctcgccc agggttcgag tcagggacaa agcagggctc gcctggtgcc tatgagcgaa
     1561 gtttccggtg gaagtatcac cagttccgct tcctctgcca ctcaaatgcc ctacccagcc
     1621 acgtgaagat cagcgtttcc aggcagactc tctttgagga ttctttccaa cagattatga
     1681 acatgaaacc ttacgacctg cgccgccggc tctacatcat catgcgtggt gaggagggcc
     1741 tggactacgg cggcatcgcc agagagtggt ttttcctcct gtcccatgag gtgctcaacc
     1801 ctatgtactg tttgtttgaa tatgctggga agaacaatta ctgcctgcag atcaacccgg
     1861 cctcttccat caaccctgac cacctcacct acttccgctt tatcggcaga ttcatcgcca
     1921 tggctctgta ccatggaaag ttcatcgaca caggcttcac cctccctttc tacaagcgga
     1981 tgctcaacaa gagaccaact ctcagggacc tggagtctat tgaccctgag ttttacaact
     2041 ccattatctg gatcaaagag aacaacctgg atgagtgtgg cctggagctg ttcttcatcc
     2101 aggacatgga gatcctgggc aaggtgacaa cccatgaact gaaggaaggc ggagagaaca
     2161 tccgagttac tgaggagaac aaggaggagt atatcatgct gctgactgac tggcgattca
     2221 cccgaggtgt ggaagagcag accaaagcct tcctggatgg cttcaatgag gtggcccctc
     2281 tggagtggtt gagatatttt gatgaaaaag agctggagct catgctgtgt ggcatgcagg
     2341 agattgacat gagtgactgg cagaagaacg ccatctatcg gcactacacc aagagcagca
     2401 agcagatcca gtggttctgg caggttgtga aggagatgga caatgagaag aggatccggc
     2461 tactgcagtt tgtcacggga acctgccgcc tgcctgttgg gggctttgct gagctcattg
     2521 ggagcaatgg accccagaag ttctgcattg acagagttgg caaggaaacc tggctgccta
     2581 ggagccatac atgcttcaac cgcctggatc tgcctcccta caagagctac gagcagctga
     2641 aagagaagct gctgtatgcc atcgaggaga ctgagggttt tggacaggag tagctgaggc
     2701 tgcccctctc acaccctcca gcacatgtag tcctgagtcc tgcctgcctg agaggccacc
     2761 ggctgcacag ccctcgagag gcccctttgg atagtggccc tgcacgagac tgtgctttga
     2821 tcatgttggt gactgaagag gccttgggga ccctttcttc tctctgatga tggcagtctg
     2881 gaataaagcc ctgtcacctt tgactcc
//
LOCUS       NM_001106156            2473 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus polycystin 2 like 2, transient receptor potential
            cation channel (Pkd2l2), mRNA.
ACCESSION   NM_001106156 XM_001061050 XM_226056
VERSION     NM_001106156.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2473)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226056.4, XM_001061050.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2473
                     /gene="Pkd2l2"
                     /note="polycystin 2 like 2, transient receptor potential
                     cation channel"
                     /db_xref="GeneID:291683"
                     /db_xref="RGD:1310272"
     exon            1..75
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1910
                     /gene="Pkd2l2"
                     /note="polycystic kidney disease 2-like 2 protein"
                     /codon_start=1
                     /product="polycystin-2-like protein 2"
                     /protein_id="NP_001099626.1"
                     /db_xref="GeneID:291683"
                     /db_xref="RGD:1310272"
                     /translation="MSEATWWHRGGTSKHDLHYRREAEVNTTLEELLLYFIFLINLCI
                     LTFGTVNPHMYYLNKVMSSLFVDTSLPDDERSSFRSIRSITEFWKFMEGPLVEGLYWD
                     SWYGNTQLDSVKNSSLIYYENILLGVPRVRQLRVRNSTCQVYPAFQSLASDCYNKYTA
                     ENEDFSDFGLKHDPEWRHSAPSSTAPWHWGFVGVYRDGGYMVTLSKSKSETKAKLADL
                     RQNNWIGRGTRAVFIDFSLYNANVNLFCIIRLLAEFPATGGILTSWQFYSVKLIRYVS
                     YYDHFIASCEIIFCIFLLVFITQELRKLNEFKSAYFRSVWNWIELLLLVLCFLAVSFY
                     AYCNVQCFLLLGQLLRSTESYPDFYFLAYWHIYYNNIIAITIFFAWIKIFKFISFNET
                     MSQLSSTLSRCMKDIVGFAIMFFIIFFAYAQLAFLVFGSQVDDFSTFQNSIFAQFRIV
                     LGDFNFAGIQQANWILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRPD
                     FELGSIIKKSCFNILEKLRLRKAQNNEDKKMKTSVDLAQARKEGFDESEIQEARQMKR
                     WKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELEKELHYLSLKLNQVMRKLH"
     misc_feature    273..860
                     /gene="Pkd2l2"
                     /note="Polycystin domain; Region: Polycystin_dom;
                     pfam20519"
                     /db_xref="CDD:466668"
     misc_feature    273..860
                     /gene="Pkd2l2"
                     /note="Polycystin domain; Region: Polycystin_dom;
                     pfam20519"
                     /db_xref="CDD:466668"
     misc_feature    861..1535
                     /gene="Pkd2l2"
                     /note="Polycystin cation channel; Region: PKD_channel;
                     pfam08016"
                     /db_xref="CDD:462341"
     misc_feature    861..1535
                     /gene="Pkd2l2"
                     /note="Polycystin cation channel; Region: PKD_channel;
                     pfam08016"
                     /db_xref="CDD:462341"
     exon            76..177
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..311
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..568
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..790
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1019
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1190
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1372
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1493
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1595
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1660
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1712
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1825
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1926
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2473
                     /gene="Pkd2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggaaccg gcagagccgc acccgccgtg tggtcctgtc ggtgatgtcc gaggcgactt
       61 ggtggcaccg aggagggact tcaaaacatg acctgcatta ccgaagggaa gcggaggtta
      121 acaccacact tgaagagttg ttactatact ttatttttct aataaatcta tgcatattga
      181 cttttgggac ggtcaaccca catatgtact acttaaacaa agtcatgtca tctctgtttg
      241 tggacacttc tctacctgat gacgaaagaa gcagctttag gtccattcgc agcataactg
      301 agttctggaa gttcatggaa ggacccctcg tggaaggctt gtactgggac tcgtggtacg
      361 gaaacacaca gctggacagc gtgaagaaca gcagcctcat ctactacgag aacattctcc
      421 tcggcgtccc cagagtgcgg cagctgcgag tccgaaacag cacttgccag gtctacccag
      481 ctttccagtc cctagccagc gactgttaca acaaatacac agcagagaat gaggacttct
      541 ctgattttgg cctcaaacat gatccagaat ggaggcactc ggctccttcc agcaccgccc
      601 catggcactg ggggtttgtc ggcgtctacc gagatggagg gtatatggtc actttatcaa
      661 aatcaaagtc tgaaaccaaa gccaaactcg ctgacctgcg gcagaacaac tggatcggca
      721 gagggaccag ggctgtcttc attgattttt cattgtacaa tgctaacgtc aacctgtttt
      781 gtatcatcag gctgctggcg gagttccctg cgacaggcgg gatcctcact tcctggcaat
      841 tctactctgt gaagctcatc agatacgtct cctactacga ccacttcatt gcctcctgtg
      901 aaattatatt ttgtattttc cttttggtct tcataacaca agaactgaga aaactgaatg
      961 agtttaagtc tgcctatttc agaagtgtct ggaactggat agaactgctg cttttggtgc
     1021 tctgtttcct tgccgtgtct ttctacgcat actgtaacgt acagtgtttt ctcttacttg
     1081 gacagctgct gaggagcacc gaaagctatc cggactttta cttccttgca tattggcaca
     1141 tttactataa caacataatt gctatcacga tcttctttgc atggataaag atattcaaat
     1201 tcataagctt caacgagacg atgtctcagc tgtcgtccac gctatcccgc tgcatgaagg
     1261 acatcgtggg cttcgccatc atgttcttca tcatcttctt cgcctacgcc cagttggcgt
     1321 ttctcgtttt tgggtcacag gttgatgact tctccacctt tcaaaattcc atatttgcac
     1381 aatttcgaat tgtcctcggg gactttaact ttgctggcat ccagcaggcc aactggatct
     1441 tggggcccat ctacttcatc accttcatct tcttcgtatt cttcgtgctc ctgaacatgt
     1501 tcttggcaat aattaatgat acctattctg aagtgaaggc cgattattcg ataggcagaa
     1561 gaccagattt tgaacttggt agcataatta agaagagttg cttcaatatt ctggagaaac
     1621 tcagactcag gaaagctcaa aataatgaag acaagaaaat gaaaaccagc gtagacttgg
     1681 cacaagccag aaaagaaggc tttgatgaaa gtgagatcca agaggcaagg cagatgaaaa
     1741 ggtggaagga aaggcttgag aaaaagtatt attctaccga aattcaagac gactaccagc
     1801 ctgtcactca gcaagaattt cgagaactct tcttatatgc ggtggagctt gagaaggagc
     1861 tacactacct gagtttaaaa ctgaaccaag tgatgagaaa gctacactaa ctcgctgacg
     1921 agtaagtcgt tttgtaagaa aaaggcaact gaagaatttc attcagtgtg aagattttcc
     1981 tctcaatttt cttcagtaat aaaaaacaaa aagtaaacaa aaaagccttg tatttccaaa
     2041 gttcttgaag taaaaagaat aaaattcttg tcctttgcta atatatgtac ctgcatgttt
     2101 gctaagtgag gagggatctg cggtaggtaa cgtggctaag tgaggagagg tctgcggtag
     2161 gtaacggggc acagcctttc cttgccctac tgagaccaca aacaaggaca aaatggaatt
     2221 ctctgagtgg ctgacaaagt gaacgcaagg acgagccaag cacacatggt ggaccatcag
     2281 ggaacacaat cactttatga tgtcaacttt caagcaacat attttatatg gattttgaag
     2341 agtcttgttt gctgataaga acttcaagaa gtctaagctt ggctttaatt cttttgtatt
     2401 ccttatattc ctcaaggact ggaacacgat cctccttctg ggcattcctg gggaagataa
     2461 aactctgtaa aat
//
LOCUS       NM_001105924            2526 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus zinc finger BED-type containing 5 (Zbed5), mRNA.
ACCESSION   NM_001105924 XM_001078332 XM_222107
VERSION     NM_001105924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001105924.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.84583.1,
                                           SRR26360172.1181469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000012.1  32449687-32449777   c
            92-344              JAXUCZ010000012.1  32448082-32448334   c
            345-495             JAXUCZ010000012.1  32446692-32446842   c
            496-2526            JAXUCZ010000012.1  32443684-32445714   c
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..2526
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="zinc finger BED-type containing 5"
                     /db_xref="GeneID:288622"
                     /db_xref="RGD:1559988"
     exon            1..91
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2315
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /EC_number="2.3.1.15"
                     /note="zinc finger BED domain-containing protein 5; SCAN
                     domain containing 3; coiled-coil-helix-coiled-coil-helix
                     domain containing protein 2-like 2"
                     /codon_start=1
                     /product="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 2"
                     /protein_id="NP_001099394.1"
                     /db_xref="GeneID:288622"
                     /db_xref="RGD:1559988"
                     /translation="MPRGSRIRTSRVTPLAGRAPQMRAAPRRAPAAQPPATAAAPSAV
                     GSPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGANAEPARPDITYQE
                     PQGAPLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANVDHPPTVDH
                     GEKNVKRRKYNEGFLQYGFTSAITAGTERPQCVICGVVLSAESMKPNKLKRHFESKHS
                     SFANKDTNYFRSKADGLKKARFDTGSKTYKQNVAAVEASYLVALRIARDMKPHTFAEH
                     LLFPVAKDSVRVMIGDEFVTKLSAVSLSNDTVRRRIHDMSADILDQVIQEIKSAQLPA
                     FSIQLDESTDVANCSQLLVYVRYIKDGDFKDEFLFCKPLERTTTALDVFEAVGSFLRQ
                     HKISWESVCGVCTDGAPATLGCQSGFQRLVLNESPKAIGAHCMMHLQTLAMKTLPQDL
                     QDVMKSVLSSVSFIKASSLNSRLFLQLCSDLDAPSKALLLHTEGRWLSRGKVLKRIFE
                     LRDELKMFFNQKAIRQFEALFSDKSELQKIAYLVDIFTILNELNLSLQGQNSSCLDLS
                     EKIQSFQMKLQLWQKKLDENKIYMLPTLSAFFEEHDVEPHKRTTVVTSVKEHLDMLAG
                     EISWYFPNLPDVPFALARNPFTVKAEDVPKTAQDEFIELTNSDAARANFSTMPVTQFW
                     VKCLQSYPILSETVLRLLLPFATTSLCETGFSSLLVIKSKYRSRLVVEDDLRCALAKT
                     TPRISDLVRKKQSQPSH"
     misc_feature    <174..371
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="Uncharacterized conserved protein, DUF2076 domain
                     [Function unknown]; Region: COG3416"
                     /db_xref="CDD:442642"
     misc_feature    <174..371
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="Uncharacterized conserved protein, DUF2076 domain
                     [Function unknown]; Region: COG3416"
                     /db_xref="CDD:442642"
     misc_feature    <948..1292
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="Domain of unknown function (DUF4371); Region:
                     DUF4371; cl46273"
                     /db_xref="CDD:480613"
     misc_feature    <948..1292
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="Domain of unknown function (DUF4371); Region:
                     DUF4371; cl46273"
                     /db_xref="CDD:480613"
     misc_feature    2058..2252
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="hAT family C-terminal dimerization region; Region:
                     Dimer_Tnp_hAT; pfam05699"
                     /db_xref="CDD:399013"
     misc_feature    2058..2252
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /note="hAT family C-terminal dimerization region; Region:
                     Dimer_Tnp_hAT; pfam05699"
                     /db_xref="CDD:399013"
     exon            92..344
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /inference="alignment:Splign:2.1.0"
     exon            345..495
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..2526
                     /gene="Zbed5"
                     /gene_synonym="Chchd2l2; Scand3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtttgttg tgtctgggcg ctgaacgtag ggacacctag gatgccacgt ggaagccgaa
       61 tccgcacttc tcgtgtgacc cctctggccg gccgggcccc tcagatgagg gctgctccca
      121 gaagagcacc agcagctcag cctccagcca cagctgccgc cccatctgca gtcggctcac
      181 ctgctgctgc ccctcggcag ccaggcctga tggcccagat ggctaccact gcagccggtg
      241 tggctgtggg ttctgcggtg gggcacaccc tgggtcacgc catcactggg ggcttcagcg
      301 gaggggctaa tgctgagcct gcgaggcctg acatcactta ccaggagcct cagggagccc
      361 cgctgcagaa ccagcagtct tttggacctt gctctctaga gatcaagcag tttctggagt
      421 gtgcacagaa ccagagcgat gtcaagctct gtgagggctt caatgaggtg ctgcggcagt
      481 gcaggattgc aaatgtggac catcccccga cagtggatca tggagagaag aatgttaaaa
      541 gaagaaaata taacgagggc tttttacagt atggttttac ctcagccatc acagcgggga
      601 ctgagagacc gcagtgtgtc atctgtgggg ttgttctctc ggcggaatct atgaagccca
      661 acaaactgaa acgccatttt gaaagcaagc attcgagctt cgccaacaag gataccaact
      721 atttcagaag caaagctgat ggactcaaga aagccagatt tgacactggc agcaagacct
      781 acaaacagaa cgtggcagcc gtggaagctt cctatttggt ggccctcaga atcgccagag
      841 atatgaaacc tcacactttc gctgagcatt tactgttccc agtggccaaa gacagtgttc
      901 gagttatgat tggagacgaa tttgttacga aattgagtgc ggtttcctta tctaacgaca
      961 ccgtccgaag aagaatccac gacatgtctg ctgatatcct cgatcaggta atccaggaaa
     1021 ttaaatcagc tcaacttcca gcgttcagta tccagctcga cgaatcgaca gacgttgcaa
     1081 actgttcaca gttactggtt tatgtgaggt atattaaaga tggggacttt aaagatgagt
     1141 ttcttttctg caaacctctt gaaaggacaa ctactgccct tgatgtattc gaggcagtcg
     1201 gctcatttct gagacagcat aagatctcct gggaaagcgt ctgtggtgtt tgcacagatg
     1261 gcgctccagc cacgctagga tgtcaatctg gtttccagcg tttggtccta aatgagtcac
     1321 caaaagccat tggagctcac tgcatgatgc atctgcagac actagcaatg aagacactgc
     1381 cacaggactt acaggacgtc atgaaaagtg tcctgagttc cgtcagtttc ataaaggcga
     1441 gctctttgaa cagtcgactg tttctgcagc tatgcagtga tttagacgct ccgagcaaag
     1501 ccctcctact tcacactgaa gggagatggc tgtcaagagg aaaagttcta aaacgtattt
     1561 ttgagcttcg tgacgagctc aaaatgtttt ttaatcagaa agccatacgg cagtttgagg
     1621 cgcttttcag tgataaaagc gaactgcaga agatagctta cttggtcgac atctttacca
     1681 tcttgaacga gttgaattta tcactgcaag gacagaattc atcatgcctc gatttgtcgg
     1741 aaaagatcca atcattccaa atgaaacttc agctctggca gaagaaactg gacgaaaata
     1801 aaatttacat gttgcctacc ttatccgctt tctttgagga acatgacgtt gaaccgcaca
     1861 aaaggacgac cgtggtgact tccgtgaaag aacacttgga catgcttgcc ggtgaaattt
     1921 cttggtactt tcccaatcta cctgacgtcc cgtttgcact tgccagaaac ccattcacag
     1981 tcaaagctga agatgtcccc aagacagcac aggacgagtt catcgagctt acaaacagtg
     2041 atgcggcgag agccaatttc tccacaatgc cagtgacaca gttctgggtc aagtgtttgc
     2101 agtcataccc gattctgtct gagacggtgt tgcgactcct ccttccattc gcaacaacat
     2161 ctctttgtga aacagggttc tccagcttgt tggtcatcaa gtccaagtac agaagtaggc
     2221 ttgtcgtgga agacgacctc cggtgtgctc tcgcaaagac taccccaaga atttctgatc
     2281 tggtgagaaa gaagcagtct caaccctcac actgatgttg gctttttaca aacagtgttc
     2341 tgaaatgtag caatgtggtt tacctcattc tagtaagact gttacccgtg ccacactgtg
     2401 cttcaagaca aaatttcata tactcgtcat tagtaataaa tatttccaca gagaaaccct
     2461 gtctcaaaaa aaaaaaaaaa aagattttac aatataaaag tacataattg tttttgtgat
     2521 taatca
//
LOCUS       NM_001437270            3191 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus checkpoint with forkhead and ring finger domains
            (Chfr), transcript variant 1, mRNA.
ACCESSION   NM_001437270 XM_006249535
VERSION     NM_001437270.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 3191)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (bases 1 to 3191)
  AUTHORS   Jung,I., Sohn,D.H., Choi,J., Kim,J.M., Jeon,S., Seol,J.H. and
            Seong,R.H.
  TITLE     SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking
            CHFR mediated ubiquitination and degradation of its major
            components
  JOURNAL   Biochem Biophys Res Commun 418 (3), 512-517 (2012)
   PUBMED   22285184
REFERENCE   4  (bases 1 to 3191)
  AUTHORS   Oh,Y.M., Kwon,Y.E., Kim,J.M., Bae,S.J., Lee,B.K., Yoo,S.J.,
            Chung,C.H., Deshaies,R.J. and Seol,J.H.
  TITLE     Chfr is linked to tumour metastasis through the downregulation of
            HDAC1
  JOURNAL   Nat Cell Biol 11 (3), 295-302 (2009)
   PUBMED   19182791
REFERENCE   5  (bases 1 to 3191)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (bases 1 to 3191)
  AUTHORS   Yu,X., Minter-Dykhouse,K., Malureanu,L., Zhao,W.M., Zhang,D.,
            Merkle,C.J., Ward,I.M., Saya,H., Fang,G., van Deursen,J. and
            Chen,J.
  TITLE     Chfr is required for tumor suppression and Aurora A regulation
  JOURNAL   Nat Genet 37 (4), 401-406 (2005)
   PUBMED   15793587
REFERENCE   7  (bases 1 to 3191)
  AUTHORS   Daniels,M.J., Marson,A. and Venkitaraman,A.R.
  TITLE     PML bodies control the nuclear dynamics and function of the CHFR
            mitotic checkpoint protein
  JOURNAL   Nat Struct Mol Biol 11 (11), 1114-1121 (2004)
   PUBMED   15467728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249535.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.33002.1,
                                           SRR26643299.51245.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000012.1  52197661-52197734   c
            75-218              JAXUCZ010000012.1  52197409-52197552   c
            219-318             JAXUCZ010000012.1  52193002-52193101   c
            319-428             JAXUCZ010000012.1  52189107-52189216   c
            429-488             JAXUCZ010000012.1  52188275-52188334   c
            489-704             JAXUCZ010000012.1  52187940-52188155   c
            705-869             JAXUCZ010000012.1  52186341-52186505   c
            870-1029            JAXUCZ010000012.1  52182610-52182769   c
            1030-1184           JAXUCZ010000012.1  52181801-52181955   c
            1185-1347           JAXUCZ010000012.1  52180867-52181029   c
            1348-1493           JAXUCZ010000012.1  52178991-52179136   c
            1494-1613           JAXUCZ010000012.1  52177359-52177478   c
            1614-1697           JAXUCZ010000012.1  52175247-52175330   c
            1698-1768           JAXUCZ010000012.1  52174142-52174212   c
            1769-1856           JAXUCZ010000012.1  52172797-52172884   c
            1857-1964           JAXUCZ010000012.1  52168910-52169017   c
            1965-2037           JAXUCZ010000012.1  52167710-52167782   c
            2038-3191           JAXUCZ010000012.1  52164212-52165365   c
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3191
                     /gene="Chfr"
                     /note="checkpoint with forkhead and ring finger domains"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
     exon            1..74
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Chfr"
                     /note="upstream in-frame stop codon"
     exon            75..218
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2080
                     /gene="Chfr"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase CHFR; checkpoint with forkhead
                     and ring finger domains, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHFR isoform 1"
                     /protein_id="NP_001424199.1"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
                     /translation="MEPHGEDEQPPPREPWGRLLRLGAEEDEPQILLWKREWTIGRRR
                     GCDLSFPSNKLVSGDHCKLRVDEKSGEVTLEDTSTNGTVINKLRVVKKQTYPLQSGDI
                     IYLVYRKNEPEHNVAYLYESLNGKQSLTQESLEANKENMFHVTKESSGPGQGDDPQVP
                     LLSPMAQTCLEEPQPSTSTSDLLPTASTSSTEPELTSAGQKHSSSSGPGTISISPKEC
                     SSLVANGELSSLSSVFQDNEASFSLLKTEDTEELEPAKKKMKGDGELDLNLQLSVADQ
                     RGIAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMER
                     SSLCPTCRCPVERICKNHILNNLVEAYLLQHPDKSRSEEDVRSMDARNKITQDMLQPK
                     VRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESEL
                     GATQALGGEAPSTSASLTTAAPGYTCPLQGSHAICTCCFQPMPDRRAEHEQDSRIAPQ
                     QCAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLTT
                     RGLTWKNMLTESLLALQRGVFILSDYRITGNTVLCYCCGLRSFRELTYQYRQNIPASE
                     LPVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN"
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    128..457
                     /gene="Chfr"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); Region: FHA_CHFR; cd22672"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    order(128..151,203..205,227..229,233..235,242..244,
                     248..253,263..268,299..319,323..361,368..379,386..409,
                     431..457)
                     /gene="Chfr"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438724"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    200..>841
                     /gene="Chfr"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]; Region: COG3456"
                     /db_xref="CDD:442679"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    order(206..214,254..259,263..265,317..328)
                     /gene="Chfr"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438724"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    980..1141
                     /gene="Chfr"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); Region:
                     RING-HC_CHFR; cd16503"
                     /db_xref="CDD:438166"
     misc_feature    1481..1945
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    1481..1945
                     /gene="Chfr"
                     /note="Cysteine rich domain with multizinc binding
                     regions; Region: zf-CRD; pfam17979"
                     /db_xref="CDD:465602"
     misc_feature    1979..2050
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     misc_feature    1979..2050
                     /gene="Chfr"
                     /note="PBZ domain; Region: zf-CCHH; pfam10283"
                     /db_xref="CDD:463043"
     exon            219..318
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            319..428
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            429..488
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            489..704
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            705..869
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1029
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1184
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1493
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1613
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1697
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1768
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1856
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1964
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2037
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..3191
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtccccga gatgtctgtt gacagcggtg gcggcgactg tgctgccggt tccgggatcc
       61 gcgcagggag ggggatgtga gtcctatgga gccacacggg gaagacgagc agccgccacc
      121 gcgggagccc tgggggaggc ttcttcgcct aggcgcagag gaggacgaac cccagatcct
      181 tctttggaaa cgcgagtgga ccatcggaag gaggagaggc tgtgacctct cttttcccag
      241 caataaactg gtctctggag atcactgtaa acttagagtg gatgaaaaat ctggtgaggt
      301 gacactggaa gacaccagca ccaatggaac agtaatcaac aaactgcgag ttgttaagaa
      361 gcagacttac cctttacaga gtggggatat catctatttg gtgtacagga agaacgagcc
      421 agagcacaat gtggcatacc tctatgaatc tttaaatggc aaacagagct taactcaaga
      481 atcccttgaa gccaataaag aaaatatgtt ccatgtgacc aaagaatcct caggtccagg
      541 gcagggtgat gacccccagg ttccactctt gtcacccatg gctcagacat gcttagagga
      601 accacagcca tcaacatcga catcagacct ccttcccacg gcctctacct cttctacgga
      661 gccagagctg acctctgcag ggcaaaagca ttcctctagc tctggacctg ggactataag
      721 catctcccca aaagaatgta gttcacttgt tgcaaatggt gaactctcta gcctttcttc
      781 agttttccaa gacaacgaag catccttttc tttgttgaaa accgaagaca ctgaggaatt
      841 ggagcctgcc aaaaaaaaga tgaaaggaga tggggagctt gacttgaacc tccagttatc
      901 agttgcagac cagcgtggaa ttgcccaaac ctcaagtgag gatgtcaaag atgcctctgt
      961 gaaaccagac aagatggagg agacactaac ctgtatcatc tgtcaagacc ttctgcatga
     1021 ctgtgtgagt ttgcagcctt gtatgcacac attttgtgcg gcttgctact ctggttggat
     1081 ggagcgttca tctctgtgcc ctacctgccg atgtccagtg gagcggattt gcaaaaacca
     1141 catcctgaac aaccttgtgg aagcatacct tctccagcac ccagataaga gtcgcagtga
     1201 agaagatgtg agaagtatgg atgcaaggaa taaaatcact caagatatgc tgcaacccaa
     1261 agtcaggagg tctttctctg atgaagaggg gagttcagag gacctgctag agctgtctga
     1321 tgttgatagt gaatcctcag acatcagtca gccatacatt gtatgcagac agtgtcctga
     1381 atacagaagg caagcagtgc agtctcttcc ttgcccagtc ccagagagtg agctgggagc
     1441 cacacaggcc cttggtgggg aagcaccttc aacatctgcc agcttgacaa cagcagcccc
     1501 gggttataca tgccctcttc agggaagcca tgccatatgc acctgctgct tccagcctat
     1561 gccggaccgg agagctgagc atgagcagga ttcccgcatc gcccctcaac agtgtgcagt
     1621 gtgcctgcag cccttctgcc acctgtactg gggctgcacg cgaactggct gctttggctg
     1681 cttggcccca ttctgtgagc tcaacctggg ggacaagtgt ttggatggag tgctgaacaa
     1741 taacaattat gagtcggata tcctgaagaa ttacctgaca accaggggtc tgacatggaa
     1801 aaatatgttg acagagagtc tcctggctct acagcggggt gtatttatac tgtctgatta
     1861 cagaatcact ggaaacaccg tgctgtgtta ctgctgtggt ctgcgtagct tccgagagct
     1921 gacctatcag tatcgtcaga acattcctgc ttcagagttg ccagtgaccg taacatcccg
     1981 tcctgattgc tactggggcc gcaactgtcg cactcaggtg aaggctcacc atgcaatgaa
     2041 attcaatcac atctgtgagc aaacaaggtt caagaactaa atattggagg agacacatga
     2101 aacagttaca gagcacagga ggcaatgata ctatggtttt tttttttaaa taccatgtac
     2161 atttttacgg ttttccctaa gcagcactga ggtttctggt cagactctct ggtgtggcga
     2221 gctttatctt cagtcacaca cacacacaca cacacacaca ctctacatgc cccactaacc
     2281 tgggaggcct actggccaca ctggccttct agtcagtgtg agaggatgag cagactgaga
     2341 tcccccctcc cactagacag ctctcccttc ctgtgtggtg gggcagtgac agtgcaggtt
     2401 tgcaggtttg caggtttgta cttctgtgtc ttttctacct tgtaccttga ctacagttaa
     2461 atgggaaagt ttgtgggaaa agctgtcaga tatgttagaa acattctccg gaaggaaagg
     2521 aagcatacgt ttacagcctc cagggatgta taggatattc ttctgtctga aaagacacag
     2581 ccttttgtat attttttatt ttaataagtt tggtggtgct tatcttctaa taagatttaa
     2641 atattaaaaa ctgtagcaca aatactataa tttataattt acaaattgac taaaattagg
     2701 aatagcctga catttggaag aatgagcata tgtttttgtt tatttaaaaa cttatcaaat
     2761 gtccaaaact gctaatcctg gggaggatgt cttgagtatc caggtccttg acacagggct
     2821 ggccaatgcc tcttgtccag caggccaagc ccttagccct ccagtccctg agagcaactc
     2881 cctgctgaag ctccagatgg ctccagactg acagggcctt gcttctccag ccctgatctg
     2941 gtacattatt aggtttgcca tgtcatctgg aataatactt gaaattttgt tcttagtttt
     3001 ttttaaactt tttatctttt attgaaatca cctgttatat ttgtttgcaa actggtaact
     3061 ttttgcttct caggaataca attttcaact gttgtcttgc tcttgatata gactgagagg
     3121 cagtactctg tgtttgtggg agatggttct ctttttttaa ttctaataaa tgagctgtgt
     3181 ttgtttctct t
//
LOCUS       NM_001108467            5666 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), transcript
            variant 1, mRNA.
ACCESSION   NM_001108467 XM_001071045 XM_006228278 XM_341782
VERSION     NM_001108467.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5666)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5666)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 5666)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 5666)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 5666)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_006228278.4, NM_001108467.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.799.1,
                                           SRR26643299.1162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000001.1  78401913-78402166   c
            255-412             JAXUCZ010000001.1  78401477-78401634   c
            413-453             JAXUCZ010000001.1  78398316-78398356   c
            454-512             JAXUCZ010000001.1  78398010-78398068   c
            513-674             JAXUCZ010000001.1  78397058-78397219   c
            675-824             JAXUCZ010000001.1  78396669-78396818   c
            825-907             JAXUCZ010000001.1  78396228-78396310   c
            908-1172            JAXUCZ010000001.1  78395632-78395896   c
            1173-1299           JAXUCZ010000001.1  78395199-78395325   c
            1300-1388           JAXUCZ010000001.1  78394918-78395006   c
            1389-1463           JAXUCZ010000001.1  78394740-78394814   c
            1464-1612           JAXUCZ010000001.1  78394489-78394637   c
            1613-1754           JAXUCZ010000001.1  78392927-78393068   c
            1755-1783           JAXUCZ010000001.1  78392786-78392814   c
            1784-1913           JAXUCZ010000001.1  78389932-78390061   c
            1914-2045           JAXUCZ010000001.1  78389705-78389836   c
            2046-2154           JAXUCZ010000001.1  78389331-78389439   c
            2155-2329           JAXUCZ010000001.1  78389017-78389191   c
            2330-2462           JAXUCZ010000001.1  78388632-78388764   c
            2463-5666           JAXUCZ010000001.1  78385332-78388535   c
FEATURES             Location/Qualifiers
     source          1..5666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5666
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..254
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..412
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    318..320
                     /gene="Eps8l1"
                     /note="upstream in-frame stop codon"
     CDS             396..2549
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001101937.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     misc_feature    489..881
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    489..881
                     /gene="Eps8l1"
                     /note="Epidermal growth factor receptor kinase substrate
                     (EPS8)-like Phosphotyrosine-binding (PTB) domain; Region:
                     PTB_EPS8; cd01210"
                     /db_xref="CDD:269921"
     misc_feature    order(510..512,747..749,807..809)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(510..512,747..749,807..809)
                     /gene="Eps8l1"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(705..722,768..770,837..839,849..851)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    order(705..722,768..770,837..839,849..851)
                     /gene="Eps8l1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269921"
     misc_feature    1839..1997
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    1839..1997
                     /gene="Eps8l1"
                     /note="Src Homology 3 domain of Epidermal growth factor
                     receptor kinase substrate 8 and similar proteins; Region:
                     SH3_Eps8; cd11764"
                     /db_xref="CDD:212698"
     misc_feature    order(1839..1856,1860..1862,1869..1871,1878..1886,
                     1905..1922,1926..1952,1965..1976,1986..1997)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1839..1856,1860..1862,1869..1871,1878..1886,
                     1905..1922,1926..1952,1965..1976,1986..1997)
                     /gene="Eps8l1"
                     /note="swapped dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1860..1862,1872..1880,1929..1937,1941..1943,
                     1968..1973,1977..1988)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    order(1860..1862,1872..1880,1929..1937,1941..1943,
                     1968..1973,1977..1988)
                     /gene="Eps8l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212698"
     misc_feature    2262..2459
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     misc_feature    2262..2459
                     /gene="Eps8l1"
                     /note="SAM domain of EPS8-like subfamily; Region:
                     SAM_EPS8-like; cd09540"
                     /db_xref="CDD:188939"
     exon            413..453
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..512
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..674
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..824
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..907
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1172
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1299
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1388
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1463
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1612
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1754
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1783
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1913
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2045
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2154
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2329
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2462
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..5666
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagagcc agcaggcagg tgagaaggcc aggcctagtg tgagtgagga gagctgagtt
       61 gtagggtctt ggatctgaga cacaaggtat cctctggacc ccggatctga acaaggagag
      121 ctgatctaga ttcttggatc tgagagataa ggttctcccc tggacccctg ggtttgaaca
      181 aggagggtct ggagtctaga ctattggatc tgagagagga ggtccctcct ggacccctgg
      241 gtcttagcaa ggaggagcca ggctggtgcc tgaacatctc agtttgaggg aggaggcttg
      301 gatcaggatc ctgtgcctga agccaagtca gtcactcacg tctttgctgg ctctcaagga
      361 acctccaagc ggacagagca cctcttctgg ccaccatgag caccaccaca gggcctgaag
      421 ctgcacccaa accaagtgca aagtctatct atgagcagag aaaacgttac tccactgtgg
      481 ttatggctga tgtgtcccag tatcatgtca atcacctggt caccttctgc ttgggggagg
      541 aagatggcgt gcacactgtg gaagatgctt ccagaaagct ggcagtcatg gacagccagg
      601 ggcgtgtctg ggcacaggag atgctactga gagtgtcacc tggtcatgtc actctgcttg
      661 atccagtctc taaggaggaa ctagagtcat atcctctcga cgccatcgta cgctgcgacg
      721 cggtgatgcc ccgaggacgg agccgctcgt tgctgctcct ggtgtgccaa gagccagagc
      781 gtgcacagcc agatgtccat ttcttccagg gcctgctcct cggggcggag ctgatccgtg
      841 aggacatcca aggggctctg cagaactacc gctccggacg tggggaacgc agggcggcag
      901 cactcagggc tacgcaggag gagctgcgac gcggtgcctc tccagcagcg gagaccccgc
      961 ccttacagcg tcgcccttct gtccgcgcgg tgatcaacac ggtggaacca tccgcggtgc
     1021 gcgggcgacc ccaagtggag ccaattccag agactgagga agcgaggaaa cccgacccag
     1081 cgcgcacgac gactaggagc tctgatccta cctccccaga cctgggccca aggggtcctg
     1141 agctggccgg tctgcaggcg gagcgggatg tggatatcct gaaccatgtg tttgacgacg
     1201 tggagagttt tgtatccaga ctgcaaaagt cagcagaggc tacccgggtt ttggagcacc
     1261 gtgagcgcgg ccgcaggaca cgacgccgag ctgctggaga gggcctgctg accctaaggg
     1321 ccaagccacc cacagaggct gaatacactg atgtgcttca gaaaatcaaa tacgccttca
     1381 gtctgctggc ccggttgcgg ggcaacatcg ccaacccctc ctctccagag ctgttacact
     1441 ttctgttcgg acctctgcag atgattgtga acacttcagg cggccctgag ttcccgagga
     1501 gtgtgcgacg accacatttg accttggagg ctgtggcgct gctccgcgac aatgtcactc
     1561 ctcgtgaaaa tgaactatgg acctcactgg gggactcctg gacccgccca ggggtggagc
     1621 tgccccctga agaagggtct ccatacagtc cggaattcta cagcggttgg gaacctccgg
     1681 ccactgaccc gcagggccgc ccctgggagg acccagtgga aaaacagcta cagcacgaga
     1741 agcggcgcag gcagcaaagc gccccccaag tcgcggtcaa tggtcatcaa gatccagaac
     1801 tggaaactga gtcccagcta gaagagaaag ccagaaaatg ggttctgtgt aattatgact
     1861 tccaggcccg aaatggcagc gagctatctg tcaagcaccg agatgtgttg gaggtcctgg
     1921 atgacaggcg caaatggtgg aaggttcggg accatcaagg acaagagggc tatgtaccct
     1981 ataatatcct gacaccccac cctggacctc aggtgcactg cagccaaagc tccgcaataa
     2041 acctagagac tagcccacct cctcccccac ctgctgcagc tccagccccc actcaggtgc
     2101 ggccccagtg ggacagttgc gacagtctaa acagtttgga tcccagcgac aaggagaaat
     2161 tttcccagat gctttgtgtc aatgaggagc tgcaggcgcg cctggcgcag ggccgttcgg
     2221 gtcccagccg ggtaaccccg gggcttcgag ccccggagcc ccagctcagc ccacgctctg
     2281 aggcctcggt ggtccgtgcc tggctgcaga ccaagggctt tagctccggg actgtggatg
     2341 cgcttggagt gctgactggc gcacagctgt tctcgcttca aaaggaagag ttgcggtcgg
     2401 tgtgcccgga agaaggggcg cgagtatata gccaagtcac tgtgcagcgg gcgctactgg
     2461 aggacagaga aaaagtatca gagctggagg ccgtaatgga gaaacaaaag aaaaaagtgg
     2521 aaggcgagac caaaacagaa gtcatttgat cctggttcat tcataaaaag tgatgagatg
     2581 gtggggttcc cagcgccccg aaagacaaca gtcaccagac tcctccccca acgtcagtag
     2641 cagtagatgc cgtaaaggac cgcccaccct gggttccccg cggtcctggc gggcggactg
     2701 cattgacagt gctgaccgga acctttccag agggactgat gggaatgggg aagggaacag
     2761 agcatggaca ctactagaaa ggcacgccca agaggcgcga tgatggccct gtgcgttgtg
     2821 atgcgctata aacagcctcc ttttaggcta tgtccacctg ctgtcccccc ccacacacac
     2881 cccctctctt gccggccacc aagatgccag gaatctagaa gacatccata ttttctctcc
     2941 acaaacctgg agattccaac ccaggcttcc tcttaagcac caatctatcc ttgctctaac
     3001 actatctaca atctctctct ggttcaaaat cctttcctgt caactagcgt gaggcctggg
     3061 attttccttt caaaggcaga gggtgtctcc ttccaccccc cattttgggt caacccctcc
     3121 aatcacaggc atttccgcac ttactgcttc tgctggttgg agcagcttcc atcaatgtgg
     3181 ctcaactcac ctacattcca tggatgcctg tgccagccac taaggattca gctatgaaga
     3241 tcgggatgct ataggctctt gggtcttcca gtccccagaa ctttctccct gccaagtcct
     3301 gcaacttgtc tggtttattt aggtggctag taagagctgg ttttctcatt gagactagat
     3361 acccctaagg tttttttttt tcctgctgtg gcacttccct ttgcatccct aaaacacttc
     3421 aagagtcaca ccagtgcagt tggcctctgc tctccaggca gttcagctct tacctgagcc
     3481 accagtggca cacctcaaat ccaagctaga aaagccagcc tttgggctga cagcttcact
     3541 atacccactt tgctccagaa cactatccac aatagatctc tttcccactt cctgtctacc
     3601 tctcaagcat gtctcttggc ttctcccgac agatgggata aaacctaacc ccagcatgaa
     3661 agttgatata catgaccact ccaggttcag ggccctcttc ctcccttttc aggaccccaa
     3721 gcattggttc gtgctgttgg ctctgctagg aatgtcctgg ccttttggag tctaatcact
     3781 gcctgtcgtt ccttatgtca gggttgggtg gttagttggt tgattggttt tgttggagat
     3841 agtctggata tagcctcaaa gtctcaattc tgtttcagtt tcctgcatgc tgagattcct
     3901 ggcagatgcc ctcctgcctt cttttctaag aaacttaaaa acacaagcag tttgcccaaa
     3961 ctgtttttga ctctgcagtg agctcccagg ctccaggctg caggctgccg tgcaggcagg
     4021 gaccagctgg cttgctggaa caccagatgc ctctagctct ctatggtctg gaatctgatc
     4081 atttctatct gcttatcctg acttcatcct ttgttgatca ccctgtccgt cactcctcca
     4141 atctgtatcg atgttcagac atagggacct gttacaactc aagtcagatg gcagtctgct
     4201 ggccagacct cccacctcag agctcaagtc cttagtagag ccacatccct gcacaaagcc
     4261 agcagcactt caacacttcc tctgctattc agccccaagt ttcttcctgc accttagcat
     4321 gccaggccta ctctacccta tgacctttgc atctcatcac tgaaaatggg cttccttcag
     4381 acatatggct cactctgcta ccttctagtt ccacgtgtca tgtcttgggt ctactttgac
     4441 taccataaac accatacata cacaccagat acatacccaa catacaccat aaacatcagc
     4501 catgccacgc accacacaaa atgcacacca cacacacacc gtccacccct gacaacaccc
     4561 atccacccac atccacttcc cttctctttc tccacagcac tacagctgaa atccatacac
     4621 tagttacctc tctcctgcag aacctggctc ctggcctaag ctactcactc ttgggactcc
     4681 agtaggtagg acagagccca gctggtagtg taggcagttg ctcctgacta taagaatgaa
     4741 ggtacaatga atcacaagac tgcctcctac tattccagcc aatgtggccg tggaggactg
     4801 agggaactca ccatcactta ttcatttccc agagaagtta cacttgtgga gttttctgtg
     4861 atccatccca cattttcaat gtcagccatt aactccactc ctttcagggg aactgagggc
     4921 aaatctgggc actccagccc cttatcacag caccatgggc ttccttctga cccttcccac
     4981 ctcatctggg atcctttgct ccagctgctc acttagcaag gtgccctccc tactcctgtg
     5041 agcacgctcc aaccttgcct ccaactgtac ctaccccatc caaatgggct tggtcagcct
     5101 gagtcaacaa gcagaacaag tcactgagtg gcaatgtcac gactttattt atggtgcctg
     5161 tgctttgtct caaaaatacc ttctcctcct ccccagacaa taggtgggga ggaggcagca
     5221 aaaatagaac atccctccct attgcacatg gaccctatat acaggcccac ctggcagagg
     5281 ccagtgggac tcttggcaca ttcctggtcc ctgctgggga gggggggagg agtgctgggt
     5341 agcatcacac gtgaggtggg accctggggc aaccactctg cttctggata cttatctttg
     5401 catttcttgg tccttgtttc cttcttggtc ccatctctga tgctcagagc aacatctcag
     5461 caacatctcc ctacctggct cagcctccca cctctatcct gacctcagag aaccccttgg
     5521 ttcctgggga ctctgtgctt tcctcccggt tctgaggtcc cgagaggtta tggcttctca
     5581 gcaacttccc ccagagcctt gtcactcatg ttcacgcggg ggaaagggtg cgtgtgtcag
     5641 aagcagcagt ataaatatgg tgcggg
//
LOCUS       NM_001437164            2216 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 1, mRNA.
ACCESSION   NM_001437164
VERSION     NM_001437164.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2216)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.77782.1,
                                           SRR26643429.54674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000018.1  69721768-69721830
            64-215              JAXUCZ010000018.1  69726124-69726275
            216-343             JAXUCZ010000018.1  69732094-69732221
            344-443             JAXUCZ010000018.1  69732881-69732980
            444-590             JAXUCZ010000018.1  69735312-69735458
            591-776             JAXUCZ010000018.1  69736741-69736926
            777-932             JAXUCZ010000018.1  69740845-69741000
            933-1040            JAXUCZ010000018.1  69741592-69741699
            1041-2216           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2216
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..63
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="upstream in-frame stop codon"
     exon            64..215
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            216..343
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1094
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 1"
                     /protein_id="NP_001424093.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MCSKTKMTEKTNPHPPLRPTESAALMRGCLRGLESVSFMEQMQR
                     IPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREPLKNLFFVLAERARGPNPRKR
                     HLAMRGLGILAHEAPDKQVRKYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQ
                     GQRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQD
                     SLLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEI
                     LLFFYANKIL"
     misc_feature    501..947
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    501..947
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    615..716
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    615..716
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    744..833
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    744..833
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            344..443
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            444..590
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            591..776
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            777..932
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1040
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..2216
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatcaag atgagcccag agggaaaagg cagacgccct gggctcctca ttgcatagct
       61 caggtaagga aaccagggct gggaaaatct cgctgactca ccacatttgg aggccaatcc
      121 cgaatcggtg gaacaacgcg cctcccgaga gacccaggac tagcctccag ccccgaaaca
      181 gcggttcttc acgtgacagt caccccagga gccagggcca tctgacctcg aaaatgtgct
      241 caaaaacaaa gatgacagag aagacaaatc cccacccacc tctacgcccc accgaatcag
      301 ctgctctgat gcgtggctgc ctaagagggc tggaatctgt cagtttcatg gaacaaatgc
      361 agagaatccc gaaccagccc ctccccaccc ctgcttctca gtccaagaag aggaggacac
      421 cactgtcatc tttcttttcc aaggtctctt ggaaactgag gttgcagaag cgggaacctt
      481 tgaagaatct gtttttcgtc ttggcagaaa gagcccgggg tcctaatcct agaaagcgcc
      541 atctagcaat gagaggcctg ggtatcttgg cccatgaagc tcctgacaag caggtgagaa
      601 agtataagaa agttatgctt gacctgctgg tacacgggct gtatgatcct gtgagttccg
      661 aagtcattca tgagagtgtg aagacgctga ctatcatgtt gggcaagatc cagggccaac
      721 ggctgggctc cttcttcata gacatcaccc ttcagacccg gaccctattg gatgatgagg
      781 atgacagcgt gcgctactca gcctttgtcc tctttgggca gttggctgca tttgctgggc
      841 ggaaatggaa gaagttcttc acccaccagg tcaaccagac ccaagattcc ctcctaagcc
      901 atttgcagga cgaaagccct caggttgcca aggcttgcac aatggctgtt caagcctgtg
      961 ttccatacct gaaacccaga aaggagcaga gtttccaaag tgaagaagac cagaagaacc
     1021 gcaggctttc ccagcaactg agccactacc atccagagat cctgctgttc ttctatgcca
     1081 ataaaatcct gtaggtccag agcagcagag aaagcccacg ggagtgccct gccccggcat
     1141 ggaatttccc atctgtctca taggatacct ctttgactct cgagtgattg taagagaaaa
     1201 gaggatgtca gagagcaact gaaaaaaaaa tcaccctgga gtgcacgcaa agtaaaattc
     1261 tatgcaagtg tgtgcacata catgcacatg actgtggagg tcagaggacg acctcactgc
     1321 tgttcctaag gcgtcatcca tctttccact gaaacaggat ctttgactgg cctggggctt
     1381 gcaggagctt agactaggct tgatagctag tgagccagct ctggggttat aaccacagtc
     1441 catcgaacca accgtttttg actgtgccaa attcaggccc ttatacctac ttgtgctgac
     1501 taagccgtct ccccagccca gtagatgcac acttccttaa aacatttaac atgcatgatg
     1561 tcccaatccc tcctttctca ctccctctct gccaggtgac acacatttat aatatgtaac
     1621 ttctgaggct tgggggaaca attgttacct taaacatttt taaactgtat ttgtttttga
     1681 tagtttgcta tttgctacgg accaggagac caaggagctg gcttacaatg tgtctttaat
     1741 ttcggatgat cttaaaatgt catggtctta aaatcgtctt taaaaagaac aacaaggaaa
     1801 agaaatattg ttgaaaatcc actgaatgat gataagttac agaataaaaa cagtaacatt
     1861 tactgagaat gcttacaact tatttcggta ctgtggtggt ttggatgagc gaccctgcag
     1921 gcttacgtat ttgaatgctt ggtcccttct tagtggaagt gtttaggagg ggttagaggg
     1981 tgtgtatatc actggagatg gaatttgaga cttcagaagc ccaagcaagg ccctgtctgt
     2041 ctgtctgtct gtctgtctgt ccgtctctta ttttgcctgc ctactgtcta cagatcaaga
     2101 cgtaaagctc tcagttacta ctctagcacc atgcctgtct actcctacca tgatgataat
     2161 gaactggcct tctaaaactc taagccagcc ccaattaaac gcttcctttt ataaga
//
LOCUS       NM_001437353            1867 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 63 (Ccdc63),
            transcript variant 6, mRNA.
ACCESSION   NM_001437353 XM_063271319
VERSION     NM_001437353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271319.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.696435.1,
                                           SRR26643293.85248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000012.1  40090950-40090986
            38-138              JAXUCZ010000012.1  40093232-40093332
            139-308             JAXUCZ010000012.1  40093729-40093898
            309-498             JAXUCZ010000012.1  40096705-40096894
            499-618             JAXUCZ010000012.1  40098953-40099072
            619-800             JAXUCZ010000012.1  40100973-40101154
            801-982             JAXUCZ010000012.1  40102786-40102967
            983-1203            JAXUCZ010000012.1  40106323-40106543
            1204-1278           JAXUCZ010000012.1  40109132-40109206
            1279-1471           JAXUCZ010000012.1  40110908-40111100
            1472-1675           JAXUCZ010000012.1  40112332-40112535
            1676-1867           JAXUCZ010000012.1  40113629-40113820
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1867
                     /gene="Ccdc63"
                     /note="coiled-coil domain containing 63"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
     exon            1..37
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            38..138
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Ccdc63"
                     /note="upstream in-frame stop codon"
     CDS             139..1815
                     /gene="Ccdc63"
                     /note="isoform 2 is encoded by transcript variant 6;
                     coiled-coil domain-containing protein 63"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 63 isoform
                     2"
                     /protein_id="NP_001424282.1"
                     /db_xref="GeneID:304484"
                     /db_xref="RGD:1562334"
                     /translation="MKKHRRKVSEPLPELSEKAKEQLAEAELRKLRQQFRKMVDSRKS
                     SNFRNQRMIASQYKEIENLKAEQAETTLLLSLVKSPKNLDLNQKNFTELRFLLQTKGD
                     YEALISSMKVLLGELDDKIVQMERKITNQRQIFLKTQEANNPRKLQKQIHILETRLNL
                     VTVHFDTMLTSNAQLRKDIEDLLFEKAAYDHVYQQLQRRLQTQKKTMNVAIEQSTQAY
                     EQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHENKLKSFLLVKLNDRTEFEDQ
                     AKKQEAVKIKKHGKKRKGESFESYEVAHLRLLKLAENGDLNQLTEDFLAKEEKNFARF
                     TYVTELNNDMETMHKRTQRIQDDIINLRSQQQSSHEGTRNILKQMEEKLRKTTEDTDI
                     YENRYREMSKTLEYLKNSVEKLFKKINCNATEILGKLGETGKITDSNLQQYFAIIEKK
                     TNDLLLLESFRRLQEAEGPDVDVPQPFVNPFWGGSALLKPPEPLRVVPPVFGADSFSD
                     KVEEVEYPLDHSSLRQLVLENYLQKERGKEPQETLLEKGDEIRVKKKVIS"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <574..1395
                     /gene="Ccdc63"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            139..308
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            309..498
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            499..618
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            619..800
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            801..982
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1203
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1278
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1471
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1675
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1867
                     /gene="Ccdc63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggccac tacccggaac cgcgggagac gtgggtggac attgcagaca gaggagacac
       61 tgagagaacg agaaagaagt gggcttgcta gctttgacct ccaggaccca gtgtctaagc
      121 agaaaggaag cttagacgat gaagaaacac aggaggaagg tctctgaacc ccttccggaa
      181 ctttccgaga aggccaaaga gcagttggct gaggcagagc tacggaaact aaggcagcag
      241 ttccggaaga tggtagacag ccgaaagtct tccaatttcc gcaaccagcg gatgatcgcc
      301 agccagtaca aggagataga gaatttgaaa gcggagcagg cagagaccac cttgcttctg
      361 agcctcgtga agtcgccaaa gaacctagac ctcaaccaga aaaatttcac ggagctgcgc
      421 ttcctgctgc agaccaaggg ggactacgag gctctgatct cctccatgaa ggtgctgctg
      481 ggagaactgg atgacaagat tgttcagatg gagagaaaga tcacaaacca gagacagatc
      541 ttcttgaaga cacaagaggc caacaatccc cggaagctgc agaaacagat ccacattctg
      601 gagaccagac tgaacctggt cactgtccac tttgacacga tgttgacctc caatgcccag
      661 ctccggaagg atattgagga tcttctcttt gagaaggctg cctacgacca tgtctaccag
      721 cagcttcagc ggcgtctgca gacacagaag aagaccatga atgtggccat cgagcagtct
      781 acccaggcct atgagcagag agtggaagcc atggctcgga tggctgccat gaaggaccgc
      841 cagcaaaaag acatctctca gtacaacctg gagatccgag agctcgaacg cctgtatgac
      901 cacgagaaca aactcaagtc ctttctgctt gtcaagctca atgaccgcac ggaattcgag
      961 gaccaggcca agaagcagga agctgtcaaa attaagaagc atgggaaaaa gaggaagggt
     1021 gagagctttg agagctacga ggtggcccat ctccgactgc taaagctggc tgagaacggg
     1081 gacctgaacc agctcactga ggacttcctg gccaaggagg agaagaattt tgctcgcttc
     1141 acctatgtca ccgagctcaa caatgacatg gagaccatgc acaagaggac ccagcggatc
     1201 caggatgaca tcatcaacct gcggtcacag cagcagtcct cccatgaggg cacccggaac
     1261 atcctgaaac agatggagga gaaactgagg aagaccaccg aggacacgga catttatgag
     1321 aacaggtaca gggaaatgag caagaccctg gagtacctca agaactcagt ggagaagctg
     1381 tttaagaaga tcaactgcaa tgccacggag atcctgggga aactgggtga gactgggaag
     1441 atcacggaca gcaaccttca gcagtacttc gctatcatag aaaagaagac aaatgacctc
     1501 ctgcttctgg agtctttccg gcgcctgcag gaggcagagg ggcccgatgt tgatgtccca
     1561 caaccctttg tcaacccctt ctgggggggc tctgccctcc tcaagccccc agagccctta
     1621 agggttgtgc cgcctgtgtt tggggcagac tccttcagtg acaaagttga agaggtggaa
     1681 taccctctgg accacagtag cctccggcag ctggtcttgg agaactacct tcagaaggaa
     1741 cgaggaaaag aaccacagga gacactgttg gagaaggggg acgagataag ggtcaagaag
     1801 aaggtgataa gctgaacccc gtgggtggct gtattccaca ccgagaaaat aaatgttttc
     1861 ttgccga
//
LOCUS       NM_001108220            1891 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 237 (Tmem237), transcript
            variant 2, mRNA.
ACCESSION   NM_001108220 XM_001064402 XM_237179
VERSION     NM_001108220.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Huang,L., Szymanska,K., Jensen,V.L., Janecke,A.R., Innes,A.M.,
            Davis,E.E., Frosk,P., Li,C., Willer,J.R., Chodirker,B.N.,
            Greenberg,C.R., McLeod,D.R., Bernier,F.P., Chudley,A.E., Muller,T.,
            Shboul,M., Logan,C.V., Loucks,C.M., Beaulieu,C.L., Bowie,R.V.,
            Bell,S.M., Adkins,J., Zuniga,F.I., Ross,K.D., Wang,J., Ban,M.R.,
            Becker,C., Nurnberg,P., Douglas,S., Craft,C.M., Akimenko,M.A.,
            Hegele,R.A., Ober,C., Utermann,G., Bolz,H.J., Bulman,D.E.,
            Katsanis,N., Blacque,O.E., Doherty,D., Parboosingh,J.S.,
            Leroux,M.R., Johnson,C.A. and Boycott,K.M.
  TITLE     TMEM237 is mutated in individuals with a Joubert syndrome related
            disorder and expands the role of the TMEM family at the ciliary
            transition zone
  JOURNAL   Am J Hum Genet 89 (6), 713-730 (2011)
   PUBMED   22152675
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Zuniga,F.I. and Craft,C.M.
  TITLE     Deciphering the structure and function of Als2cr4 in the mouse
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 51 (9), 4407-4415 (2010)
   PUBMED   20375344
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064402.1, XM_237179.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1891
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="transmembrane protein 237"
                     /db_xref="GeneID:316412"
                     /db_xref="RGD:1306705"
     exon            1..173
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    112..114
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="upstream in-frame stop codon"
     exon            174..205
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            206..262
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            263..400
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..518
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1341
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 4"
                     /codon_start=1
                     /product="transmembrane protein 237 isoform 2"
                     /protein_id="NP_001101690.1"
                     /db_xref="GeneID:316412"
                     /db_xref="RGD:1306705"
                     /translation="MDVEPREEVVIPKPRRKAKKMQPAEPQYASELGVEDEDVITDEQ
                     STLEHHSRFTAPTGVSQPVGKIFVEKSRRFQAADRSELIKTTENVDVSMDMKPSWTTR
                     DVALSVHRAFRMIGLFSHGFLAGCAVWNIVVICVLAGDQFSNVSNLLQQYKPLAYPFQ
                     SLLYLLLALSTVSAFDRIDFAKTSVAIRNFLALEPTALASFLYFTALTLSLSQQMTSD
                     RIYLYEPSVNGSLWPAEVEEPVLMPWVIVNLVVALLVGLAWLFLSYRPGMDLSEELMF
                     FSDVDEYPERGVKASP"
     misc_feature    541..1269
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="Transmembrane protein 237; Region: TMEM237;
                     pfam15383"
                     /db_xref="CDD:464690"
     misc_feature    541..1269
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="Transmembrane protein 237; Region: TMEM237;
                     pfam15383"
                     /db_xref="CDD:464690"
     exon            519..676
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            677..800
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            801..992
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1066
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1157
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1279
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1891
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacctctg ggcggctctc ggctgcaggc aaagcgggag aggaggctgt ttccggtggg
       61 agcttgaatc ctggtctggt caagcggtgc tcatccccac gcaaatcgtg atgacctccc
      121 gggaaactgt gggtgaaccc cctccgctcc tggggacgtc gacatacgct gagcgtcctc
      181 cgcgagcact tccacctgtg ccaagatgag attccactta gtcatcctaa gaaaaagaaa
      241 tccagaacaa agagcacacc agctcctgct tcttcagaag gccttgctga gcccgttgtt
      301 aacaggaggg ctgagggcag tgagccacca gctgcagaac tcaaggagta cccagaggct
      361 cctgttcaaa ggaaacagaa gaagataaga ccacctcctg agttggagac ttccttcact
      421 gaaaagccat ccagtccgtc tttactacgg aatgaaaacg gcatggacgt ggagcctcgt
      481 gaggaagtgg ttattccaaa acctcgaagg aaggcgaaga aaatgcagcc agcggaacca
      541 cagtatgcca gcgagctagg ggtagaagat gaagacgtaa ttacggatga gcagagcact
      601 ctagaacacc actctaggtt caccgcaccc accggagtca gccagcctgt tggcaaaata
      661 tttgtggaaa aaagccggag atttcaggcg gcggaccgtt cggagttgat aaagaccaca
      721 gaaaacgtag atgtgtcaat ggacatgaag ccatcttgga ctacccgcga tgtggcactt
      781 tccgtgcacc gagctttcag gatgatcggc ctcttctctc acggcttctt ggctggctgt
      841 gctgtgtgga atattgttgt gatctgtgtt ctcgcgggag accagttctc taatgtctcc
      901 aaccttctgc agcagtacaa gcccttggca tatcccttcc agagccttct ttacttgctt
      961 ttggctctaa gtacagtttc agcatttgac aggatcgact ttgctaaaac ctcagtagca
     1021 atccggaact ttttggccct ggagccaaca gctttagcct ctttcttgta ttttactgct
     1081 ctaacactat ctctgagtca gcaaatgaca agtgacagaa tctaccttta cgaaccttct
     1141 gtcaatggaa gcctctggcc agcagaagtg gaggaaccgg ttctcatgcc atgggtcata
     1201 gtgaatctgg tggtggcgct tctggttgga ttagcctggc tctttttgtc ttacaggcca
     1261 ggcatggatc ttagtgaaga gttgatgttc ttttctgatg tggacgagta ccccgagaga
     1321 ggagtcaaag cgtctccgta gcgccggccg gctccgtccc tgcagtgacg gcctgcgttc
     1381 cccactcccg tttttaagtg tatttttata agatacatgt atttataatc gagcttttgt
     1441 tacataatgc tgaaatgcta ctgtagattg taaattatat ctggtcttta taccaaatat
     1501 tagggtcttt attattttca ccttagtgac acaggagata atgagctaaa acaaacaaac
     1561 aaacaaacaa aaaaacacag caggtgatgt gtttgtttcc tgtcctttca aatttgcaaa
     1621 attcatgatt attattagct aaagagcacc aatttagaaa agccttaacc tcagtgttat
     1681 aaaatataca tcaagtttaa atgtaaattt agtgaatggg gaagatggaa aaatgtcttc
     1741 attttatatt tttgatgtct tcttatggaa cactgcagga tgtgatttgt tttctctgaa
     1801 tctggctagt gttatagctc atataataat tatttgccat ttgaattgaa agatgcttta
     1861 tagctaataa aacagaaata cctatctttg a
//
LOCUS       NM_001436870            4501 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus calsyntenin 1 (Clstn1), transcript variant 1,
            mRNA.
ACCESSION   NM_001436870 XM_039110100
VERSION     NM_001436870.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Zhou,F., Hu,R., Wang,Y., Wu,X., Chen,X., Xi,Z. and Zeng,K.
  TITLE     Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models
  JOURNAL   Synapse 78 (5), e22307 (2024)
   PUBMED   39171546
  REMARK    GeneRIF: Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models.
REFERENCE   2  (bases 1 to 4501)
  AUTHORS   Ster,J., Steuble,M., Orlando,C., Diep,T.M., Akhmedov,A.,
            Raineteau,O., Pernet,V., Sonderegger,P. and Gerber,U.
  TITLE     Calsyntenin-1 regulates targeting of dendritic NMDA receptors and
            dendritic spine maturation in CA1 hippocampal pyramidal cells
            during postnatal development
  JOURNAL   J Neurosci 34 (26), 8716-8727 (2014)
   PUBMED   24966372
REFERENCE   3  (bases 1 to 4501)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   4  (bases 1 to 4501)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4501)
  AUTHORS   Vagnoni,A., Perkinton,M.S., Gray,E.H., Francis,P.T., Noble,W. and
            Miller,C.C.
  TITLE     Calsyntenin-1 mediates axonal transport of the amyloid precursor
            protein and regulates Abeta production
  JOURNAL   Hum Mol Genet 21 (13), 2845-2854 (2012)
   PUBMED   22434822
  REMARK    GeneRIF: findings show that amyloid precursor protein (APP) and
            calsyntenin-1 are co-transported through axons, that loss of
            calsyntenin-1 disrupts axonal transport of APP and that
            calsyntenin-1 loss also leads to altered APP processing and
            increased production of Abeta
REFERENCE   6  (bases 1 to 4501)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4501)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
  REMARK    GeneRIF: Calsyntenin-1 links a certain type of vesicular and
            tubulovesicular organelles to the Kinesin-1 motor.
REFERENCE   8  (bases 1 to 4501)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   9  (bases 1 to 4501)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4501)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_039110100.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21972.1,
                                           SRR26643297.21145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000005.1  165314338-165314634
            298-420             JAXUCZ010000005.1  165347091-165347213
            421-450             JAXUCZ010000005.1  165356823-165356852
            451-646             JAXUCZ010000005.1  165357948-165358143
            647-855             JAXUCZ010000005.1  165359104-165359312
            856-1005            JAXUCZ010000005.1  165361662-165361811
            1006-1191           JAXUCZ010000005.1  165362057-165362242
            1192-1440           JAXUCZ010000005.1  165364336-165364584
            1441-1562           JAXUCZ010000005.1  165364894-165365015
            1563-1725           JAXUCZ010000005.1  165367642-165367804
            1726-1782           JAXUCZ010000005.1  165370536-165370592
            1783-1940           JAXUCZ010000005.1  165372011-165372168
            1941-2089           JAXUCZ010000005.1  165372364-165372512
            2090-2316           JAXUCZ010000005.1  165372762-165372988
            2317-2487           JAXUCZ010000005.1  165373487-165373657
            2488-2633           JAXUCZ010000005.1  165373961-165374106
            2634-2769           JAXUCZ010000005.1  165375061-165375196
            2770-2954           JAXUCZ010000005.1  165375492-165375676
            2955-4501           JAXUCZ010000005.1  165376081-165377627
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4501
                     /gene="Clstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
     exon            1..297
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3152
                     /gene="Clstn1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alc-alpha; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 1 precursor"
                     /protein_id="NP_001423799.1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
                     /translation="MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVD
                     KSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEY
                     APVFKEKSYKAAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGY
                     IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEP
                     GTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGT
                     SELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWM
                     RHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKL
                     NQVCDEDWHHFVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQEY
                     SGVESGNETEPVTMASAGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLD
                     LQVPEDGNRGVQIQTSSSQAVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKIT
                     STVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPEL
                     KIISTITREVEPEADGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDV
                     ARLQQKGIEVNHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELN
                     GRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVV
                     PSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNP
                     METYEDQHSSEEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNTTRQQQL
                     EWDYSTLSY"
     sig_peptide     207..290
                     /gene="Clstn1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    327..683
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    327..683
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,555..557,561..563,672..674,678..683)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    order(348..353,555..557,561..563,672..674,678..683)
                     /gene="Clstn1"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    708..980
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    708..980
                     /gene="Clstn1"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1299..>1637
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1299..>1637
                     /gene="Clstn1"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     Region: Laminin_G_3; pfam13385"
                     /db_xref="CDD:463865"
     misc_feature    1902..2960
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     misc_feature    1902..2960
                     /gene="Clstn1"
                     /note="Calsyntenin C-terminal; Region: CLSTN_C; pfam19699"
                     /db_xref="CDD:466150"
     exon            298..420
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..450
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..646
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..855
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1005
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1191
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1440
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1562
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1725
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1782
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1940
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2089
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2316
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2487
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2633
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2769
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2954
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..4501
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccgcc gccgccgcct ccagcgcagc gctgccgacg aggggagggc gcgcgcggcc
       61 cagcagcacg gcggctgccg ctcacatccc ggtgctcgcc gcgccgccca gccgctggcc
      121 cccggctgcc cgcacccctc tcggcgtccc gcgcgactcc ctgctgcttc cgcgtcgggc
      181 cggccgcggc gctccgagcc cgagcgatgc tgcgccgccc tgcgcccgcg ctggcccggg
      241 ctgtccggct gctgctggcg gggctgctgt acggcggcgg ggtctgggcc gcgcgagtta
      301 acaagcacaa gccatggctg gagcccacct accacgggat cgtcaccgag aacgataaca
      361 cggtgctgct cgaccccccc ctcatcgccc tggacaaaga ctcaccgctg cgctttgcag
      421 agagttttga ggtgacagtc accaaagaag gtgagatttg tggctttaaa atccacgggc
      481 agaatgtccc cttcgatgcc gtggtagtgg ataagtccac gggtgaggga ataatccgat
      541 caaaagagaa actggactgt gagttgcaga aagactatac attcaccatc caggcctacg
      601 actgcgggaa gggacccgat ggcaccggtg tgaaaaaatc tcacaaagca accgtgcaca
      661 tccaggtgaa cgacgtgaat gagtacgccc ccgtgttcaa ggagaagtcg tacaaggcgg
      721 ccgtggtgga gggcaagcag cacggcagca tcctcagggt ggaggccgtg gatgcagact
      781 gctcgcccca gttcagccag atctgcagct atgagattct caccccagat gtgccgttca
      841 ctgtggacaa agacggttac atcaaaaaca cagagaagct taactacggc aaagagcatc
      901 agtataagct cactgtcacc gcctatgact gtgggaagaa aagagccacg gaggacgtcc
      961 tggtgaagat cagcgttaag cccacctgca gccccgggtg gcaaggctgg agcagcagaa
     1021 ttgaatatga gcccggcaca ggcgctttgg ccgtcttccc gagcatccac ttggagacct
     1081 gcgacgagcc tgtcgcctct gtgcaggcca cagtggagct ggagaccagc cacataggga
     1141 aaggctgcga ccgagacacc tactccgaga agtccctcca ccggctctgt ggggctgctg
     1201 ctggtacctc agagctgctc ccgtcgccca gtagctcctt caattggacc gtcggcctcc
     1261 ccactgacaa cggccatgac agtgaccagg tctttgagtt caatggcaca caggcggtgc
     1321 ggatcccaga cggtgttgtg acccttgacc ccaaagagcc ttttacaatt tccgtgtgga
     1381 tgcggcatgg gccttttggc cggaagaagg agacaattct ctgcagttcg gataaaacag
     1441 atatgaaccg acaccattat tcgctctatg tccacgggtg cagactcatt ttcctcctcc
     1501 gtcaggaccc gtctgaggag aagaagtaca ggcctgcgga gttccactgg aagctgaacc
     1561 aagtctgtga tgaggattgg caccactttg tcctcaatgt ggaagtccca agtgtgaccc
     1621 tctatgtgga cggcgtctct catgagccct tctccgtgac cgaggactac ccacttcatc
     1681 caaccaaaat agaaactcag cttgtggtcg gagcttgctg gcaagagtac tcaggagtcg
     1741 aaagtggcaa tgagactgag cctgtgacga tggcctctgc aggtggtgac ctgcacatga
     1801 cgcagttttt ccgaggtaac ctggctggcc tcacagtccg ttctgggaaa ctggcagata
     1861 agaaagtgat cgactgtctg tacacctgca aagaggggct ggacctgcag gtccctgagg
     1921 atggcaacag aggggtgcag atccaaacaa gctccagtca ggcggtattg accttggagg
     1981 gggagaatgt cggagagttg gataaggcca tgcagcacat ttcttacctc aactcaaggc
     2041 agttccccac accaggcatc cgcaggctga aaatcaccag caccgtcaag tgctttaatg
     2101 aggcggcttg catcgaggtg cctccggtgg agggctacgt gatggtttta cagccagaag
     2161 aacccaagat cagcctgagt ggggtccacc actttgcccg cgcagcttcc gagtttgaga
     2221 gcccggaggg tgtttccctt ttccctgagc tgaaaatcat aagcaccatc accagagagg
     2281 tggagcccga ggcggacggg gctgaggacc ccacagtgca agagtccctg gtgtcggagg
     2341 agattgtgca cgacctggac acctgtgagg tcacggtgga aggggaggag ctgaacgcag
     2401 agcaggagag cctagaggtg gacgtggccc gcctccagca gaagggcatc gaagtgaacc
     2461 actctgacct gggcgtggtc ttcacaggtg tggaaaccat ggcaagctac gaggaggttc
     2521 tgcacctcct gcgctatcgg aattggcaca ccaggtccct gctggaccgg aagttcaagc
     2581 tcatttgctc ggaactaaat ggtcgttacc tcagcaacga gttcaaggtg gaggtgaatg
     2641 tgatccacac agccaacccc gtggaacacg ctaatcacat ggccgcccag ccacagtttg
     2701 tccaccctga acaccgatcc ttcgtggacc tgtctggtca caacttggcc agtcctcacc
     2761 catttgcagt tgtccccagc acggcgactg tcgtgattgt ggtatgtgtc agcttcctgg
     2821 ttttcatgat catcctgggg gtgtttcgga tccgagctgc acatcagcga acgatgcggg
     2881 accaggacac cgggaaggag aacgagatgg actgggatga ctctgccttg accatcactg
     2941 tcaaccccat ggagacgtac gaggaccagc acagcagtga ggaggaggaa gaagaggaag
     3001 aggaggagga gagtgaagac ggggaggagg aggaggacat caccagtgcc gagtcagaga
     3061 gcagtgagga ggaggaaggc ggccccgggg acggccagaa caccacccgg cagcagcagc
     3121 tagaatggga ctactccaca ctcagctact aaacacgcgc tcgcccagca cctgctctcc
     3181 agactctccc agccatcttc cagccccacg ggtccacgat gtacaaatca ttttgaccag
     3241 caggtctgca gacccctccc ccattgctga aagtcctccc gtgcttggtg tgtgggacca
     3301 caggctccgc cctccctgcc catcacgctt gcagttttgc ttaggagctg gcccttcctc
     3361 ccagtgcagg ggccccacag cacctcagac cccaagtgtg tctggagtcc cctgtcagcc
     3421 agggagagga caccagcacc tgggacctcc agagaagccg cagtgagcgg acttgtcgac
     3481 agagggtaaa aaattactcc cacgcagtca tcatttttct tcatttttaa aagtttttat
     3541 ttttattttc caatatagtg catgtataaa gtgggagagc ggggaggggg ggttaatatg
     3601 tagatgacca actgactttt taatattttg taaataaatt gggattcttt gtgtcctttg
     3661 tgctagtgta gtccaggaca ggaatgtgaa gtcagaacat ggggccagga agagctcttc
     3721 ctcccttttc cctcccaaga aaccaggttg gaaaggtcca agtcacagtg gcccatgctg
     3781 gggtttctgt acagccatgt ggccagggcc ataggttttg agtgctgcct gggggagcca
     3841 gacccacgcg ctcccaccac attagaggct gggaacagcc aggatggtgc caaagcccct
     3901 ggccttcctt gtacacgcct gtgaccagcc tcgtggcttc tgctaattag cgtgtctccc
     3961 tgttggtgaa aacctgtagc tgggaactga tggcaaagat ggacaacagt tctgagcagt
     4021 ctgcactaca gcacccaaga ggagaacctg aggcccgaaa acaaactgct acaatgtttc
     4081 aaaacgagct gcgctctcct ccccagagac cccacgggat gcccccggga tgcccccttg
     4141 ctgtcgggtt ttggctaaga cctaagaccc agcagaggag agccagccgg cttggggggt
     4201 gggggtgggg gaggagacag cagctaaaac ccacacagca cggcttgtca ttcacagtca
     4261 cagtttagac tcctccagct ggggaatccg gtcctcgctg ctagtcctaa ggatgttgac
     4321 gctgtgctgc ctgtggccac cctcccgtgt cctgttccct gtagtcgctt tatagatgga
     4381 aacaggctat gaagagggac actgtcgtgt gttggtagcc gcaggctccc cttaagatgt
     4441 gtatattgac cccaggtcag gaagtgtatg cgttataata aagttctggt tctaactcca
     4501 a
//
LOCUS       NM_001100970            3798 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus AE binding protein 1 (Aebp1), transcript variant
            1, mRNA.
ACCESSION   NM_001100970 XM_001069152 XM_223583
VERSION     NM_001100970.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Blackburn,P.R., Xu,Z., Tumelty,K.E., Zhao,R.W., Monis,W.J.,
            Harris,K.G., Gass,J.M., Cousin,M.A., Boczek,N.J., Mitkov,M.V.,
            Cappel,M.A., Francomano,C.A., Parisi,J.E., Klee,E.W., Faqeih,E.,
            Alkuraya,F.S., Layne,M.D., McDonnell,N.B. and Atwal,P.S.
  TITLE     Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly
            and Connective Tissue Structure Resulting in a Variant of
            Ehlers-Danlos Syndrome
  JOURNAL   Am J Hum Genet 102 (4), 696-705 (2018)
   PUBMED   29606302
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Lyons,P.J., Muise,A.M. and Ro,H.S.
  TITLE     MAPK modulates the DNA binding of adipocyte enhancer-binding
            protein 1
  JOURNAL   Biochemistry 44 (3), 926-931 (2005)
   PUBMED   15654748
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   He,G.P., Muise,A., Li,A.W. and Ro,H.S.
  TITLE     A eukaryotic transcriptional repressor with carboxypeptidase
            activity
  JOURNAL   Nature 378 (6552), 92-96 (1995)
   PUBMED   7477299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001100970.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133065.1, SRR26643299.55417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               JAXUCZ010000014.1  84952849-84953291
            444-782             JAXUCZ010000014.1  84954813-84955151
            783-854             JAXUCZ010000014.1  84955673-84955744
            855-926             JAXUCZ010000014.1  84955866-84955937
            927-1037            JAXUCZ010000014.1  84956044-84956154
            1038-1106           JAXUCZ010000014.1  84956229-84956297
            1107-1184           JAXUCZ010000014.1  84957278-84957355
            1185-1265           JAXUCZ010000014.1  84957676-84957756
            1266-1322           JAXUCZ010000014.1  84957838-84957894
            1323-1432           JAXUCZ010000014.1  84958491-84958600
            1433-1572           JAXUCZ010000014.1  84958674-84958813
            1573-1657           JAXUCZ010000014.1  84959126-84959210
            1658-1802           JAXUCZ010000014.1  84959304-84959448
            1803-1888           JAXUCZ010000014.1  84959545-84959630
            1889-2012           JAXUCZ010000014.1  84959858-84959981
            2013-2209           JAXUCZ010000014.1  84960193-84960389
            2210-2389           JAXUCZ010000014.1  84960472-84960651
            2390-2741           JAXUCZ010000014.1  84960852-84961203
            2742-2881           JAXUCZ010000014.1  84961286-84961425
            2882-2981           JAXUCZ010000014.1  84961523-84961622
            2982-3798           JAXUCZ010000014.1  84962024-84962840
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3798
                     /gene="Aebp1"
                     /note="AE binding protein 1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
     exon            1..443
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Aebp1"
                     /note="upstream in-frame stop codon"
     CDS             197..3583
                     /gene="Aebp1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adipocyte enhancer-binding protein 1; aortic
                     carboxypeptidase-like protein"
                     /codon_start=1
                     /product="adipocyte enhancer-binding protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001094440.1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
                     /translation="MAAVRTASLLCGLLALLALCPEGSPQTVLTDDEIQEFLEGFLSE
                     FETQSPPREDDVEAQPLPEPTQRARKSKAGGKPRADAEAPPEKNKDKEKKGKKDKGPK
                     AAKHLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKR
                     PSAGKRFSTVAPLETPERSLTSPSNPGTRELPEERGRTSLNTWQGQGEETQVEARQHR
                     PEPEEETEMPTLDYNDQIEREDYEDFEYIRRQKQPRPTPSRKRIWPEPPEEKTQEPEE
                     RKEVDPPLKPLLPPDYGDGYLIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEELKKPKK
                     EGSSPKEDTEDKWAAEKNKDHKAGPRKGEELEEEWGPVEKIKCPPIGMESHRIEDNQI
                     RASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVI
                     TQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVV
                     ARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLM
                     KVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGMHGNEVLGR
                     ELLLLLMQYLCHEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL
                     WTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAII
                     SWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAALAAARGEDEDEVSEAQET
                     PDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYL
                     HTNCLELSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIAN
                     ATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNF
                     ILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRLQQRRLRYRLRMREQMRLRRL
                     NSTTGPATSPTPALTLPPSPTPGSTSRLWEILPTTAAGWEESETETYTEVVTEFETEY
                     GPDLEVEELEEEEEEEEEMDTGLTFPVTTVETYTVNFGDF"
     sig_peptide     197..271
                     /gene="Aebp1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     272..3580
                     /gene="Aebp1"
                     /product="Adipocyte enhancer-binding protein 1.
                     /id=PRO_0000333191"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     misc_feature    314..1300
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1328..1789
                     /gene="Aebp1"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    1328..1789
                     /gene="Aebp1"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    1340..1837
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Required for DNA-binding and interaction with
                     NFKBIA. /evidence=ECO:0000250"
     misc_feature    1433..2044
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
     misc_feature    order(1472..1474,1556..1558,1577..1579)
                     /gene="Aebp1"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
     misc_feature    order(1472..1474,1556..1558,1577..1579)
                     /gene="Aebp1"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
     misc_feature    1754..1756
                     /gene="Aebp1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A2RUV9.1); glycosylation site"
     misc_feature    1835..3127
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with PTEN. /evidence=ECO:0000250"
     misc_feature    1862..2881
                     /gene="Aebp1"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; Region: Peptidase_M14_like; cl11393"
                     /db_xref="CDD:472171"
     misc_feature    1862..2881
                     /gene="Aebp1"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; Region: Peptidase_M14_like; cl11393"
                     /db_xref="CDD:472171"
     misc_feature    order(2045..2047,2054..2056,2240..2242,2267..2272,
                     2459..2464,2480..2482,2792..2794)
                     /gene="Aebp1"
                     /note="active site"
                     /db_xref="CDD:349427"
     misc_feature    order(2045..2047,2054..2056,2240..2242,2267..2272,
                     2459..2464,2480..2482,2792..2794)
                     /gene="Aebp1"
                     /note="active site"
                     /db_xref="CDD:349427"
     misc_feature    2891..3118
                     /gene="Aebp1"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; Region: Peptidase_M14NE-CP-C_like;
                     cd11308"
                     /db_xref="CDD:200604"
     misc_feature    2891..3118
                     /gene="Aebp1"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; Region: Peptidase_M14NE-CP-C_like;
                     cd11308"
                     /db_xref="CDD:200604"
     misc_feature    2993..3580
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Required for transcriptional repression.
                     /evidence=ECO:0000250"
     misc_feature    3188..3580
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
     misc_feature    3275..3364
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            444..782
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..854
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..926
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1037
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1106
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1184
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1265
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1322
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1432
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1572
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1657
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1802
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1888
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2012
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2209
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2389
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2741
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2881
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2981
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3798
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccggag ctgggctcgc cagaacctct ctcggaatcc ccttgaatct ctctccccca
       61 cccctttctg gataccctcg acgtccacgt tgctccccag ggttcctcac gccctttccc
      121 gcccccacgc ggggcgccgc ccctgccacc caagtccctg ctcaagccca cccgactccc
      181 acgcgtgccc agagccatgg ctgcggtacg caccgcatcc ctgctctgcg gcctcttggc
      241 actcctggcg ctgtgcccgg aggggagccc acagacggtg ctgacggacg acgagatcca
      301 ggagttcctc gaaggcttcc tttcggagtt tgagacccag tccccgcccc gggaggacga
      361 cgtggaagcc cagccacttc ccgaacccac ccagcgtgcc cgcaaatcca aggcaggggg
      421 caagccgcgg gcagatgcag aagcccctcc agaaaagaac aaagacaaag agaagaaagg
      481 aaagaaggac aaaggcccca aggctgcaaa acacctggaa ggttccacca ggcccaccaa
      541 gaaaccaaag gagaagccac ccaaggccac caagaagccc aaagagaagc cacccaaggc
      601 caccaagaag cctaaagaga agccacccaa ggccaccaag aagcccaagg agaagccacc
      661 caaggccact aagaggccct cggcaggaaa gagattctca actgtagccc ccttagaaac
      721 gccggagcgt tcactcacct caccctccaa ccccggcacc agggagctac cagaggagag
      781 aggaagaacc tccctgaata cctggcaggg ccaaggagaa gagacccaag tggaggccag
      841 gcagcaccgg ccagagccag aggaggagac cgagatgccc acactggact acaatgacca
      901 gatagagcgg gaagattatg aagactttga gtacatcagg cgccagaagc agcccagacc
      961 cacacccagc aggaagagga tctggccaga gccccctgag gagaagaccc aagagccgga
     1021 ggaaaggaag gaagttgatc cgcctctgaa gcccctgttg ccccctgact atggggatgg
     1081 ctacttgatc cccaactacg atgacttgga ctactacttc ccccaccccc caccacagaa
     1141 gcccgatgtt ggacaagagg tggatgaaga aaaggaggag ttgaagaagc ccaaaaagga
     1201 gggcagtagc cccaaggagg acacagaaga caagtgggcg gcagagaaaa acaaggacca
     1261 caaagcagga ccccggaagg gcgaggagct ggaggaggag tggggtccag tggagaaaat
     1321 caagtgccca cctatcggga tggagtcaca ccgcattgag gacaaccaga tccgcgcctc
     1381 ctccatgctg cgccatggcc tcggagccca gcggggccgg ctcaacatgc aggctggtgc
     1441 caatgaagat gactactatg atggggcatg gtgtgctgag gacgagtctc agacccagtg
     1501 gattgaggtg gacacccgga ggacgactcg gttcacaggc gtgattacac agggtcggga
     1561 ctccagcatc catgacgact ttgtgactac cttcttcgtg ggcttcagca atgacagcca
     1621 gacctgggtg atgtacacca atggctatga ggaaatgacc ttccatggga atgtggataa
     1681 ggacacacct gtgctgagtg aactccccga gccagttgtg gcccgtttca tccgcatcta
     1741 tccactcacc tggaacggta gcctgtgcat gcgcctggag gtgctaggct gccctgtgac
     1801 ccctgtctac agctactacg cacagaacga ggtggtgacc actgacagcc tggacttccg
     1861 gcaccacagc tacaaggaca tgcgccagct gatgaaggtt gtgaatgagg agtgtcctac
     1921 cattacccgc acgtacagct tgggcaagag ttcacgaggg ctcaagatct atgcgatgga
     1981 gatctcagac aaccccgggg agcatgagct gggggagcct gagttccgct acacagccgg
     2041 catgcacggc aatgaggtgc tgggccgaga gctgctgtta ctgctcatgc agtacctgtg
     2101 tcacgagtac cgggatggga accccagagt gcgtaacctg gtgcaggaca cgcgcatcca
     2161 cctggtgcct tcgctgaacc ctgacggcta cgaggtggca gcgcagatgg gctcagagtt
     2221 tgggaactgg gcactggggc tgtggactga ggagggcttt gacatcttcg aggatttccc
     2281 agatctcaac tctgtgctct gggcagctga ggagaagaaa tgggtcccct acagggtccc
     2341 gaacaataac ttgccaatcc ctgaacgtta cctgtcccca gatgccacgg tatccacaga
     2401 agtccgggcc atcatttcct ggatggagaa gaaccccttt gtgctgggtg caaatctgaa
     2461 tggtggcgag cggcttgtgt cttaccccta tgacatggcc cggacaccta gccaggagca
     2521 gctgttggcc gcggcactgg cagctgcccg tggagaagac gaggatgagg tgtctgaggc
     2581 ccaggagact ccagatcacg ccattttccg ctggctggct atctcctttg cctctgccca
     2641 tctcaccatg actgagccct accggggagg gtgccaggcc caggactaca ccagcggcat
     2701 gggtatcgtc aacggggcca agtggaatcc tcggtctggg actttcaatg acttcagcta
     2761 cctgcatacc aactgcctgg agctctctat atacctgggc tgcgacaagt tcccccacga
     2821 gagcgagctg ccccgagagt gggagaacaa caaagaagcc ttgctaacct tcatggagca
     2881 ggtgcaccgt ggcatcaagg gtgtggtgac ggatgagcaa gggatcccca ttgccaatgc
     2941 taccatctct gtgagtggca tcaaccacgg agtaaagaca gcgagtggag gtgactactg
     3001 gcgcattctg aacccgggtg agtaccgtgt gacagctcac gcagagggct acacctcgag
     3061 tgccaagatt tgcaacgtgg actacgatat cggggccacc cagtgcaact tcatcctggc
     3121 gcgctccaac tggaagcgca ttcgggagat cttggctatg aacgggaacc gtcccattct
     3181 ccgagttgac ccctcacgac caatgacacc ccagcagcgg cgcctgcagc agcgccggct
     3241 acggtaccgg ctcaggatga gggaacagat gaggctgcgg cgcctcaatt ctaccacagg
     3301 ccctgccacg agccccactc ctgcccttac gctgcctcct tcccctacac caggcagtac
     3361 ctcgaggctc tgggaaattc tacccactac cgctgcgggc tgggaggagt cagagactga
     3421 gacctataca gaggtagtga cagagtttga gacagagtat gggcctgacc tggaggtgga
     3481 ggaactggag gaggaggagg aggaggagga ggagatggac acaggcctca cgtttccagt
     3541 cacaacagtg gagacctaca cagtcaactt tggggacttc tgagactggg gtcccaaagc
     3601 cctagcccaa ttcaaactaa agcagcattt ccccagcctg tgctggcagg cgcatagcca
     3661 tcagatgctc ctgggtgggc cctgttacca ccaggcctcc aaaagcagag tctctgcaga
     3721 agcccccggt tctacctgcc agcctttggg gaggcaagga agccaacgtc acaccaataa
     3781 aacaagctca cggcacca
//
LOCUS       NM_001437346            6943 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus kinetochore associated 1 (Kntc1), transcript
            variant 1, mRNA.
ACCESSION   NM_001437346 XM_008769228
VERSION     NM_001437346.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6943)
  AUTHORS   Civril,F., Wehenkel,A., Giorgi,F.M., Santaguida,S., Di Fonzo,A.,
            Grigorean,G., Ciccarelli,F.D. and Musacchio,A.
  TITLE     Structural analysis of the RZZ complex reveals common ancestry with
            multisubunit vesicle tethering machinery
  JOURNAL   Structure 18 (5), 616-626 (2010)
   PUBMED   20462495
REFERENCE   2  (bases 1 to 6943)
  AUTHORS   Chan,G.K., Jablonski,S.A., Starr,D.A., Goldberg,M.L. and Yen,T.J.
  TITLE     Human Zw10 and ROD are mitotic checkpoint proteins that bind to
            kinetochores
  JOURNAL   Nat Cell Biol 2 (12), 944-947 (2000)
   PUBMED   11146660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_008769228.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.47971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000012.1  38500362-38500456   c
            96-269              JAXUCZ010000012.1  38497839-38498012   c
            270-390             JAXUCZ010000012.1  38495972-38496092   c
            391-506             JAXUCZ010000012.1  38494374-38494489   c
            507-579             JAXUCZ010000012.1  38493836-38493908   c
            580-657             JAXUCZ010000012.1  38492937-38493014   c
            658-692             JAXUCZ010000012.1  38491527-38491561   c
            693-812             JAXUCZ010000012.1  38491157-38491276   c
            813-906             JAXUCZ010000012.1  38489505-38489598   c
            907-959             JAXUCZ010000012.1  38488544-38488596   c
            960-1075            JAXUCZ010000012.1  38488164-38488279   c
            1076-1130           JAXUCZ010000012.1  38487768-38487822   c
            1131-1229           JAXUCZ010000012.1  38486823-38486921   c
            1230-1273           JAXUCZ010000012.1  38485558-38485601   c
            1274-1339           JAXUCZ010000012.1  38485384-38485449   c
            1340-1415           JAXUCZ010000012.1  38485222-38485297   c
            1416-1538           JAXUCZ010000012.1  38483618-38483740   c
            1539-1628           JAXUCZ010000012.1  38483438-38483527   c
            1629-1682           JAXUCZ010000012.1  38482038-38482091   c
            1683-1744           JAXUCZ010000012.1  38481100-38481161   c
            1745-1856           JAXUCZ010000012.1  38479512-38479623   c
            1857-2000           JAXUCZ010000012.1  38477886-38478029   c
            2001-2057           JAXUCZ010000012.1  38477301-38477357   c
            2058-2159           JAXUCZ010000012.1  38476996-38477097   c
            2160-2279           JAXUCZ010000012.1  38475497-38475616   c
            2280-2423           JAXUCZ010000012.1  38475259-38475402   c
            2424-2522           JAXUCZ010000012.1  38473773-38473871   c
            2523-2626           JAXUCZ010000012.1  38472421-38472524   c
            2627-2726           JAXUCZ010000012.1  38472193-38472292   c
            2727-2861           JAXUCZ010000012.1  38471746-38471880   c
            2862-2981           JAXUCZ010000012.1  38470582-38470701   c
            2982-3054           JAXUCZ010000012.1  38469250-38469322   c
            3055-3122           JAXUCZ010000012.1  38468177-38468244   c
            3123-3403           JAXUCZ010000012.1  38467023-38467303   c
            3404-3576           JAXUCZ010000012.1  38466489-38466661   c
            3577-3674           JAXUCZ010000012.1  38465945-38466042   c
            3675-3813           JAXUCZ010000012.1  38464463-38464601   c
            3814-3870           JAXUCZ010000012.1  38463233-38463289   c
            3871-4034           JAXUCZ010000012.1  38462355-38462518   c
            4035-4139           JAXUCZ010000012.1  38461776-38461880   c
            4140-4268           JAXUCZ010000012.1  38458868-38458996   c
            4269-4385           JAXUCZ010000012.1  38457367-38457483   c
            4386-4495           JAXUCZ010000012.1  38456883-38456992   c
            4496-4700           JAXUCZ010000012.1  38454718-38454922   c
            4701-4790           JAXUCZ010000012.1  38451901-38451990   c
            4791-4962           JAXUCZ010000012.1  38449273-38449444   c
            4963-5021           JAXUCZ010000012.1  38449135-38449193   c
            5022-5235           JAXUCZ010000012.1  38448817-38449030   c
            5236-5309           JAXUCZ010000012.1  38448214-38448287   c
            5310-5520           JAXUCZ010000012.1  38447790-38448000   c
            5521-5630           JAXUCZ010000012.1  38447567-38447676   c
            5631-5677           JAXUCZ010000012.1  38443844-38443890   c
            5678-5756           JAXUCZ010000012.1  38441686-38441764   c
            5757-5875           JAXUCZ010000012.1  38440119-38440237   c
            5876-6011           JAXUCZ010000012.1  38439607-38439742   c
            6012-6107           JAXUCZ010000012.1  38438956-38439051   c
            6108-6164           JAXUCZ010000012.1  38438356-38438412   c
            6165-6219           JAXUCZ010000012.1  38436256-38436310   c
            6220-6283           JAXUCZ010000012.1  38435991-38436054   c
            6284-6413           JAXUCZ010000012.1  38434225-38434354   c
            6414-6503           JAXUCZ010000012.1  38433440-38433529   c
            6504-6649           JAXUCZ010000012.1  38432818-38432963   c
            6650-6740           JAXUCZ010000012.1  38432071-38432161   c
            6741-6943           JAXUCZ010000012.1  38429925-38430127   c
FEATURES             Location/Qualifiers
     source          1..6943
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15-q16"
     gene            1..6943
                     /gene="Kntc1"
                     /note="kinetochore associated 1"
                     /db_xref="GeneID:304477"
                     /db_xref="RGD:1307905"
     exon            1..95
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Kntc1"
                     /note="upstream in-frame stop codon"
     exon            96..269
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..6758
                     /gene="Kntc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinetochore-associated protein 1; kinetochore-associated
                     protein 1-like"
                     /codon_start=1
                     /product="kinetochore-associated protein 1 isoform 1"
                     /protein_id="NP_001424275.1"
                     /db_xref="GeneID:304477"
                     /db_xref="RGD:1307905"
                     /translation="MWNNIELLTSDDTGSGFLNVGSRKESVTALYQVDLLGKISSEKT
                     SLSPKIQACSLSDGFIIVADQSVILLDSTCRSLQLFLIFDTDVDVVGLCPEGKFLFVG
                     ERSGNFHLIYVTSKRTLFTKAFVEKAEDERTYRSLVIEKDGSNEGTYYMLLLTNNGFF
                     YITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTESYHSSGCLNLLASQSGKFANE
                     TSVIIGGTGSCAFSKWEPDSTKKDMSLKNFVDTDIIRGAKSFQLIDNLLFVLDTDNVL
                     SLWDAYTLTPVWNWPSLPIEQFLLTTEADSPSSVTWQGITNLKLVTLTATTKEKMRNL
                     IIYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVHKNDPNLCEDSVSNLELRYL
                     TEVLPENRLSRLLHKHRFADAESFAIQFGLDVELVYKVKSNDILEKLALISDKSEQSE
                     WQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRTLPAC
                     SDDFLEVLKAHAKLTTFYGAFGPEKFSGSAWVEFLNNEDDLKDIFVQLSEGNFDCAQY
                     LWLRHRADFESKFDVKMLENLLNSISTQIPVEKLCSWFKNDVIPFVRRIVPEGQNILA
                     KWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDKFGFSSSWHWISLKDYQNTEEV
                     QQLRTLVSKLQELIILHRKYNCRLALSEFEKENATTVVFRMFDRVSAPELIPSVLEKF
                     VRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFD
                     AVLKIMYKAVVPWSAAVEQLVRQHLEMDHPKVKLLQESYRLMEMKKLLRGYGIREVNL
                     LNKEIMRVVRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRVIDLIDRDQGEDCLLL
                     LRSLPPSEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSMDILKILCDIQKD
                     NLQKKDDAEEFLKRFKMVASLQENFEVFLPFEDYSDTGLVAGLREQYIKAQENAQAEH
                     KFRGPPGPTPAMGTNASVKSKLHRQALVLQVSTQELEAEMALRALKDGKVAVALSKCR
                     DLLKHYCNADTGRLLFVVCQKLCHMLADDVPMVAPVGLNLPSEIHDLTCHAVTICSPD
                     FLLDVLELSKYTLTAVELCRQCQMDDCGILMKAAVGTHKDPYEEWSYSDFFSEDGIVL
                     ESQVVLPVIYELISSVVPLAEGKRRPLDSISLPYCSTSEGENLILPLVSSISALLRNL
                     QESSQWELALRFVVASFGTCLQHSVSNVMSMSLSEKLLGKSTLASSRQIIMELKEKSI
                     AFIRGSATTLLHKVFNCRLVDLDLALAYCTLLPQKDVFENLWKFIDKAWQNYDKILAL
                     SLVGSRLANLYQDVETGLRFHELSIDAKWGIRLGKLGISFQPAFRQNFLSKKDLIKAL
                     VNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTTSQSQGGDAPEPTQHQHSKLL
                     QKATEMVPLLKSTKDLVISLTEILYKLDPYDYEMIEVVLKVIEQANEKITTVNINQAL
                     NLLRHLKSYRRMSPPVDLEYQYMLEHLITLPPAAQTRLPFHLILFGTAQNFWKILSSE
                     LSEESLPTLLLISKLMKFSLDTLYVSTAKHVFEKNLKPKLLKSAQARSSVMSKEVDKL
                     VQTLESYLLSIVNPEWAVAIAISLTQEIPEGPFKMTSLKFCLYLAERWLQNIPPQDET
                     CEKVKALQKKLYLQFRLSGTEAVLIAHKLNDQEYLRVVGKPAHLIVSLYEHPSISERL
                     CTTSGKDYPDIHAAAKEIAEVNEINLEKIWDMLLEKWLCPSTAPGEKASEFFELEEDE
                     VLHRVVYLLQARPIDYSSRMLFVFATSATSTLGIRQLTFAHRARALQCLLYLADKETI
                     ESLFKKPTEEMKSYLKCITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHEPMA
                     VRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSVHSLWQVPYFSKAW
                     QRVIQIPLLSASCPLRPSQLADCCESLVAILECPVSDDLDMMGVAKQYVQLELPAFAL
                     TCLTLMPHSEKRHQQIKNFLNSCDAQIILQQLEEHMNAGQLAGLSQQIRSLVLNHVVN
                     KKEFGILAKTKYFQLLKRHVINTDNVTELVNYLANDLSLDEASSLITEYSKHCGKPVP
                     ADTAPSEILKTFLGS"
     misc_feature    1596..>2372
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    1596..>2372
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    4878..6521
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     misc_feature    4878..6521
                     /gene="Kntc1"
                     /note="Rough deal protein C-terminal region; Region:
                     Rod_C; pfam10493"
                     /db_xref="CDD:463114"
     exon            270..390
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..506
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..579
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..657
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..692
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..812
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..906
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..959
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1075
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1130
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1229
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1273
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1339
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1415
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1538
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1628
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1682
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1744
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1856
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2000
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2057
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2159
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2279
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2423
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2522
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2626
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2726
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2861
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2981
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3054
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3122
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3403
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3576
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3674
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3813
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3870
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4034
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4139
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4268
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4385
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4495
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..4700
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4790
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..4962
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..5021
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5235
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..5309
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5310..5520
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5521..5630
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5677
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..5756
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5757..5875
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            5876..6011
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6012..6107
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6164
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6165..6219
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6220..6283
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6284..6413
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..6503
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6504..6649
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6650..6740
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
     exon            6741..6943
                     /gene="Kntc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcaggg aacctaaaat gagtaggggc ggttgtgtca gtaaggaaga agtgtgaaac
       61 acttgagaat tctcttttaa tttcttcagc tgcagggaga tcgtggcgcc ttccttcctc
      121 tgaaggacag tcttggggac atgtggaaca atatcgagct gctaaccagc gatgacacgg
      181 gaagtggatt cctcaatgtt ggctcacgaa aagaaagcgt gactgcactg taccaggtgg
      241 acttgcttgg gaagatctcc tctgagaaga cctcactgag tcccaagatc caagcatgca
      301 gcttaagcga tgggttcata atcgtggcag accagtcagt gatactgctt gacagtacat
      361 gcagatccct tcagctgttt cttatattcg acactgacgt ggacgtggtt ggcctgtgtc
      421 cagaaggaaa gtttctcttt gtgggggaga gaagcggcaa ctttcatctt atctatgtaa
      481 catcgaagcg aactctgttc accaaggcct ttgtggagaa agccgaggat gagcgtactt
      541 accggagtct cgttattgag aaagatggtt caaatgaagg tacctattat atgttgcttc
      601 tgacgaacaa cggatttttt tacattacaa acctccagct ttcacaaatt gaacaagcaa
      661 ttgagaacac agacttggat tcagccaaga agttgcaagg acaattcaaa tgtagtttta
      721 tttctactga aagttaccac agttctggtt gcctcaatct cctggcatct caatctggaa
      781 aatttgcaaa tgaaacttct gtgataattg ggggaactgg tagctgtgcg ttctcaaaat
      841 gggaaccaga ttctaccaag aaagacatgt ctcttaagaa ctttgtggac acggacatta
      901 ttagaggtgc aaagtcattt cagctgatcg acaatctgct ttttgtgctt gatactgata
      961 atgtgctgag cttgtgggat gcttatactc tcactccggt gtggaactgg ccttctcttc
     1021 ccatagagca gtttctcctc acgacagaag cggactcccc ctcttcagtt acctggcaag
     1081 ggattacaaa cctcaaatta gtcacgctga cagctaccac gaaggagaag atgagaaacc
     1141 tcatcattta ttcgttaccc acgatggaaa tactgtattc tttggaagtg tctagtgttt
     1201 cttctttagt tcaaacagga attagcacgg acaccatata ccttctggaa ggagttcaca
     1261 aaaatgatcc taacctatgt gaagactctg tgtctaactt agaacttagg tacctcacag
     1321 aggtgttacc agaaaacaga ctgagccggc tacttcacaa gcacagattt gccgatgccg
     1381 agagctttgc cattcagttt ggactggacg ttgagcttgt ttataaggtc aaatcaaatg
     1441 atatattgga gaagctggct ttgatctcag acaagagcga gcagtccgaa tggcagcaac
     1501 ttgtagatga agccaaagaa aacctatgca aaatccagga cgatgacttc gtggtgaatt
     1561 tctgcctcaa ggcccaatgg gtcacctatg aaaccaccca ggaaatgctc agttatgcca
     1621 aaaccaggct catgaagaaa gaagacagaa ctctacctgc ctgctctgat gacttcttgg
     1681 aggtgctaaa agctcatgcg aagttaacta cattttatgg agcatttgga ccagagaaat
     1741 tcagtggtag cgcttgggtt gaattcctga ataatgaaga tgacctcaag gatatttttg
     1801 tgcagctaag tgagggaaac ttcgattgtg ctcagtatct ttggcttaga catcgggctg
     1861 actttgaaag caagttcgac gtgaaaatgc tggagaattt gctgaactca atatctacac
     1921 aaatccccgt ggaaaaactc tgttcctggt ttaaaaacga cgtgattccc tttgtgagga
     1981 ggattgtgcc cgaaggacaa aacattcttg caaaatggct ggaacaagcc tcgaggaacc
     2041 tagagctaac ggataaggca aactggccag aaaatggact tcaactggca gaggtcttct
     2101 tcactgcaga aaaaactgac aaatttggat tctcgtcctc ttggcactgg atctccttga
     2161 aggattatca aaacacggag gaagtccaac agttgcggac actggtgagc aagttgcagg
     2221 agctgatcat cctgcatagg aaatacaact gcaggctggc cctctctgag tttgagaagg
     2281 aaaatgccac cactgtggtg ttccgcatgt tcgacagggt ctcggcccca gagctgatcc
     2341 cttctgtctt agagaagttc gtgagagttt acattcggga acagaatttg caagaggagg
     2401 aacttctttt gctctatata gaggacttac taaagaggtg cagctctaag tcaatgacac
     2461 tgttcgacac cgcgtgggaa gcgaaggcca tggccgtgat aagatgcttg tctgacacag
     2521 atctcatctt cgacgctgtg ctgaagataa tgtacaaggc cgtggttccc tggagtgccg
     2581 ctgtggagca gctggtgaga cagcatctgg aaatggacca ccccaaagtc aagttattac
     2641 aggaaagcta cagactcatg gagatgaaga aactcttgcg aggctatggg ataagagagg
     2701 tgaatctctt gaacaaggaa ataatgagag tggtccgcta cattctcaag caagacatcc
     2761 cgtcgtcttt agaagatgct ctgaaggtgg cccaagggta caggctgtcc gacgacgaaa
     2821 tctacagtct aagggtcatt gatctgattg accgagatca gggggaagat tgtctcctgc
     2881 tcctgaggtc tctgcctccc agtgaagctg agaaaaccgc agaaagagtc atcatctggg
     2941 ctcgactggc actgcaagaa gagcctgacg gttctgaaga ggacaaggcc tggagaatat
     3001 ctgtggcgaa gacatcgatg gatattctca aaatcctgtg tgatattcag aaagacaatc
     3061 tgcagaagaa ggatgacgct gaagaattcc tgaagcgatt taaaatggtt gctagtttac
     3121 aggagaactt cgaggtcttc cttccatttg aggattacag cgacactggc ttggtagctg
     3181 gccttcgaga acagtacatt aaggcacagg agaatgcaca ggctgagcac aaattcaggg
     3241 gacccccagg gcccaccccg gccatgggga caaacgcgag cgtcaagtca aagctgcaca
     3301 gacaggccct ggtcctgcag gtgtctacac aggaactgga ggcagagatg gctctgagag
     3361 ccctaaagga cggaaaggtg gcagtagccc tgagcaaatg cagggattta cttaagcatt
     3421 actgcaatgc cgacacaggg cgattgctgt tcgtggtgtg tcagaagctc tgtcacatgc
     3481 tggctgacga cgtcccaatg gtagccccag taggactcaa ccttccttct gagatccatg
     3541 atctcacatg ccacgctgtc accatctgca gtccagattt cctgctggat gttctagaac
     3601 tgagtaaata cactttgacc gctgtggagc tttgcagaca gtgccagatg gatgactgtg
     3661 ggattctgat gaaggctgcc gtcgggacac acaaggatcc ctatgaagag tggtcctaca
     3721 gtgacttctt cagtgaagac ggaattgttc ttgagtcaca ggtggtgctg cctgtcatct
     3781 atgaactgat ctcatcagtg gtgcccctgg cagaaggcaa aagacgccct ttggattcta
     3841 taagcttgcc atactgttcc accagtgaag gagaaaacct tattctcccc cttgtcagtt
     3901 ccatctctgc tctgctccgg aaccttcagg aatccagtca gtgggaactg gcgctcaggt
     3961 tcgtggtggc ctcctttggt acctgcctgc agcactctgt gtctaacgtc atgagcatga
     4021 gtttaagtga gaagctactt ggcaagagca cactggcgag ctcaaggcag atcattatgg
     4081 aactgaaaga gaagtccatc gcattcatca gaggaagcgc cacgacactc ctgcataaag
     4141 tgtttaactg tcgtctggtg gatctggacc tcgccttggc ttactgcact ctcttaccgc
     4201 aaaaggatgt gtttgaaaac ctctggaagt tcatagataa agcgtggcag aattacgaca
     4261 aaatcctggc attatctctg gtaggctctc ggctggcaaa tctctaccag gatgttgaaa
     4321 caggacttcg gttccatgaa ctcagtatcg atgccaagtg gggaattcgc cttggtaaac
     4381 ttggtatttc ctttcagccg gctttcagac aaaatttcct cagcaagaaa gaccttatta
     4441 aagctctcgt gaataacata gatatggaca caagcctcat tctggagtat tgcagcactt
     4501 ttcagctgga ctcggacgcc gcccttcggc tgttcattga gaccctgctc cgtaacacta
     4561 ccagccagag ccagggaggg gatgccccgg agcccacaca gcatcagcat tccaaactcc
     4621 tgcagaaagc cacagagatg gtccccttgc tgaagagcac aaaggacctg gtgatcagtc
     4681 ttaccgaaat cctttataag ctggacccat atgattatga aatgattgaa gttgtcctga
     4741 aagttataga gcaagctaac gaaaagataa ccacagtgaa cattaaccag gctctgaatc
     4801 ttctgagaca cttgaagtca tacagaagaa tgtccccacc agtggacctc gagtaccagt
     4861 acatgctgga gcacttgata acgctgccac cagccgccca gactagactg ccctttcacc
     4921 taatattatt tggcacagca cagaacttct ggaaaattct ctcctcggag ctcagcgaag
     4981 agtcacttcc aaccctgctc ttaatctcta agctaatgaa gttctcccta gatactctct
     5041 atgtgtctac cgccaaacac gtttttgaaa aaaacctgaa gccaaagctc ctgaagtcag
     5101 cacaagccag gtcctccgtg atgagcaagg aagtggataa gctcgtgcag accctggagt
     5161 catacctcct gtccatcgtc aaccccgagt gggccgtcgc cattgccatc agtctcaccc
     5221 aggagatccc agaaggcccc ttcaagatga ctagtttgaa attctgcctg tatttagctg
     5281 agagatggct acaaaacatc ccacctcagg acgagacatg cgaaaaggtc aaggccttgc
     5341 agaagaagct gtacctccag tttcggctct cgggaacgga ggccgtgctc atagcccaca
     5401 agctgaatga tcaggaatat ttaagagtgg tagggaagcc agcgcacctc atcgtgagcc
     5461 tctatgagca tcccagcata agcgaaagac tttgtaccac atctggcaaa gattatcccg
     5521 atattcacgc agcagctaaa gagatagccg aagtcaatga gattaacttg gaaaaaatat
     5581 gggacatgct gttggagaaa tggttgtgtc cctcaacggc gcccggtgag aaagcatcgg
     5641 agttctttga gcttgaagag gatgaagtgc tacatagagt cgtgtatctc ctccaggctc
     5701 gcccgatcga ttatagctcc aggatgctgt tcgtattcgc cacttcagcc acaagtacac
     5761 tgggcatacg gcagctaacg tttgcccaca gagcacgagc tcttcagtgc ctcctctact
     5821 tggctgacaa ggaaaccata gaatctctct tcaaaaagcc caccgaagaa atgaaatcct
     5881 atctgaaatg tataactttc ctggcatcat tcgagacatt gaatattccc atcacatatg
     5941 aattattctg caacagtccc aaagaaggca tgattaaggg cttgtggaag aaccacagcc
     6001 acgaacctat ggcagtacgg ttggtggcag agctttgctt agaatacaaa atctatgacc
     6061 tgcagctttg gaatgggctc ctgcagaagc ttctgggctt caacatgatc ccttacctaa
     6121 ggaaagtcct gtcctgcatt tctagcgtcc attccttatg gcaggttccc tacttcagca
     6181 aagcttggca gcgtgtaatc cagatccctc tgctctcagc ttcctgtcct ttaaggccca
     6241 gtcagttagc agactgttgt gagagtctcg tcgccatcct tgaatgtcca gtttcagatg
     6301 acctcgacat gatgggcgtc gccaagcagt atgtccagtt agagcttcct gcttttgcac
     6361 tgacctgtct gacgctcatg ccccactctg aaaaaagaca tcagcagatc aagaatttcc
     6421 tgaattcatg tgatgctcag atcattttac agcaattgga ggagcatatg aacgctggcc
     6481 agttagcagg gctttcacag cagattagaa gtctggttct gaatcatgtc gtaaataaga
     6541 aggaatttgg gattttggca aagacaaagt attttcagtt gttgaaacgg cacgtgatca
     6601 acaccgacaa cgtcactgag ttggtaaact atttagcaaa tgacttgagt ttggatgaag
     6661 catcatctct gataactgag tattcaaagc attgtgggaa gcctgtgcca gcagacacag
     6721 ctccctctga gatcctgaag acattccttg gatcgtagtc aaacaaacaa gtttttgaaa
     6781 ccaagaggaa ggtcggagtc tgctgctaat taatcatatt tattgtagtg tacaaattgt
     6841 gcaatctgta ttttgttatc ctgcaaggaa taaataaaac ttcaatattg acatggctga
     6901 cctgaatatc tcacagggtt tgttaataaa tattttgatg ttg
//
LOCUS       NM_001437580            5468 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus myocyte enhancer factor 2a (Mef2a), transcript
            variant 7, mRNA.
ACCESSION   NM_001437580 XM_008759541
VERSION     NM_001437580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5468)
  AUTHORS   Carrillo,E.D., Hernandez,D.I., Clara,M.V., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Exercise increases MEF2A abundance in rat cardiac muscle by
            downregulating microRNA-223-5p
  JOURNAL   Sci Rep 13 (1), 14481 (2023)
   PUBMED   37660209
  REMARK    GeneRIF: Exercise increases MEF2A abundance in rat cardiac muscle
            by downregulating microRNA-223-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5468)
  AUTHORS   He,T., Huang,J., Chen,L., Han,G., Stanmore,D., Krebs-Haupenthal,J.,
            Avkiran,M., Hagenmuller,M. and Backs,J.
  TITLE     Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5
  JOURNAL   J Mol Cell Cardiol 145, 88-98 (2020)
   PUBMED   32485181
  REMARK    GeneRIF: Cyclic AMP represses pathological MEF2 activation by
            myocyte-specific hypo-phosphorylation of HDAC5.
REFERENCE   3  (bases 1 to 5468)
  AUTHORS   Meyer,M., Berger,I., Winter,J. and Jurek,B.
  TITLE     Oxytocin alters the morphology of hypothalamic neurons via the
            transcription factor myocyte enhancer factor 2A (MEF-2A)
  JOURNAL   Mol Cell Endocrinol 477, 156-162 (2018)
   PUBMED   29928931
  REMARK    GeneRIF: the present study reveals a previously unknown OTR-coupled
            MAPK-MEF-2A pathway, which is responsible for oxytocin-induced
            neurite retraction of hypothalamic neurons.
REFERENCE   4  (bases 1 to 5468)
  AUTHORS   Wu,R., Wang,J., Yao,J., Dong,Z., Liu,Y. and Liu,M.
  TITLE     MEF2A regulates Calpain 3 expression in L6 myoblasts
  JOURNAL   Gene 668, 204-210 (2018)
   PUBMED   29783071
  REMARK    GeneRIF: MEF2A is a transcriptional regulator for Capn3 gene
            expression.
REFERENCE   5  (bases 1 to 5468)
  AUTHORS   Zhu,B., Carmichael,R.E., Solabre Valois,L., Wilkinson,K.A. and
            Henley,J.M.
  TITLE     The transcription factor MEF2A plays a key role in the
            differentiation/maturation of rat neural stem cells into neurons
  JOURNAL   Biochem Biophys Res Commun 500 (3), 645-649 (2018)
   PUBMED   29678571
  REMARK    GeneRIF: MEF2A participates in neuronal differentiation/maturation
            from neural stem cells.
REFERENCE   6  (bases 1 to 5468)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 5468)
  AUTHORS   Lin,X., Shah,S. and Bulleit,R.F.
  TITLE     The expression of MEF2 genes is implicated in CNS neuronal
            differentiation
  JOURNAL   Brain Res Mol Brain Res 42 (2), 307-316 (1996)
   PUBMED   9013788
REFERENCE   8  (bases 1 to 5468)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   9  (bases 1 to 5468)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5468)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_008759541.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1302.1,
                                           SRR26643292.2341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345329,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  130392055-130392171 c
            118-170             JAXUCZ010000001.1  130365401-130365453 c
            171-364             JAXUCZ010000001.1  130337632-130337825 c
            365-568             JAXUCZ010000001.1  130317243-130317446 c
            569-700             JAXUCZ010000001.1  130293170-130293301 c
            701-920             JAXUCZ010000001.1  130290825-130291044 c
            921-980             JAXUCZ010000001.1  130289823-130289882 c
            981-1168            JAXUCZ010000001.1  130277028-130277215 c
            1169-1295           JAXUCZ010000001.1  130267560-130267686 c
            1296-1422           JAXUCZ010000001.1  130263566-130263692 c
            1423-5468           JAXUCZ010000001.1  130258083-130262128 c
FEATURES             Location/Qualifiers
     source          1..5468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5468
                     /gene="Mef2a"
                     /note="myocyte enhancer factor 2a"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
     exon            1..117
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            118..170
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..364
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    299..301
                     /gene="Mef2a"
                     /note="upstream in-frame stop codon"
     CDS             311..1792
                     /gene="Mef2a"
                     /note="isoform 4 is encoded by transcript variant 7;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform 4"
                     /protein_id="NP_001424509.1"
                     /db_xref="GeneID:309957"
                     /db_xref="RGD:1359360"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLAESSMLSPPPATLHRNVSPGAPQRPPSTGSAGGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSVGKVMPTKSPPPPGGGSVGMNSRKPDLRVVIP
                     PSSKGMMPPLNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTS
                     ADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNINI
                     KSEPISPPRDRMTPSGFQQQQQQQPQQQPPPQPPQPQPQPRQEMGRSPVDSLSSSSSS
                     YDGSDREDPRGDFHSPIVLGRPPNAEDRESPSVKRMRMDTWVT"
     misc_feature    311..>1015
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    311..>1015
                     /gene="Mef2a"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     Region: ARG80; COG5068"
                     /db_xref="CDD:227400"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    314..544
                     /gene="Mef2a"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(314..322,326..328,332..334,347..349,353..355,
                     365..370,377..382,386..391,398..403,407..412,422..424)
                     /gene="Mef2a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    order(371..373,392..397,404..409,413..418,425..427,
                     440..442,446..448,452..454,470..472,476..478,494..496,
                     503..508,515..517,524..529)
                     /gene="Mef2a"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    485..487
                     /gene="Mef2a"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    <683..>1420
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     misc_feature    <683..>1420
                     /gene="Mef2a"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); Region: Herpes_BLLF1; pfam05109"
                     /db_xref="CDD:282904"
     exon            365..568
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            569..700
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            701..920
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            921..980
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1168
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1295
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1422
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..5468
                     /gene="Mef2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatgtcc cggcgagtcc cgggctgaag gaggcggctc cgggcggcgc ggagtgctgt
       61 ggcgggccgg gccggggctg cggcgtatgc gcgcccgccg gctgtagcgg agactcggaa
      121 ttgcatcttg tggaaaagga acaaagaaga actttctgca aggataaaat atttttaaga
      181 caatttcagc ggcagccttg gactggaagg ttaaataata ggaactgtgt acgatgcatt
      241 aggatattga agaaaattag cttctgaatt aattatttgg aatataagga agaaaaggtg
      301 acttttgaaa atggggcgaa agaaaataca aattacacgc ataatggatg agaggaaccg
      361 acaggtgact tttacaaagc gaaagttcgg attgatgaag aaagcctatg aactcagtgt
      421 gctctgtgac tgtgagatag cactcatcat cttcaacagc tctaacaagt tgtttcagta
      481 cgccagcact gacatggaca aagtccttct caagtacacc gagtacaacg agcctcatga
      541 aagcaggacg aactcggata ttgtggagac tttaagaaag aaaggcctta atggttgtga
      601 gagccctgat gctgacgatt actttgagca cagtccactc tcggaggaca gattcagcaa
      661 actaaatgaa gatagtgatt ttattttcaa acgaggccct cctggcttgc cgcctcagaa
      721 cttctcaatg tctgtcacag tccctgtgac cagccctaat gctttgtcgt acactaaccc
      781 agggagttca ctcgtgtcac cgtctttggc agccagctca acattagcag agtccagcat
      841 gctgtctcca cccccagcca cgctacatag aaatgtgtct ccaggagctc cgcagagacc
      901 accaagcact ggcagtgcag gtgggatgtt gagcactaca gacctcacgg taccaaatgg
      961 agctggaaat agtcctgtgg ggaatggatt tgtaaactca agggcctctc caaatttgat
     1021 tggaaatact ggtgcgaata gtgtaggcaa agtcatgcct acaaagtccc ccccgccacc
     1081 aggtgggggc agtgttggaa tgaacagtcg gaaaccagat ctacgggttg tcattccccc
     1141 ttcaagcaag ggcatgatgc ccccacttaa tgcccaaagg ataagtagtt ctcaagccac
     1201 acaacctctt gccacgcccg tggtgtctgt gacaactcca agcttgcctc cgcagggact
     1261 agtgtactcg gccatgccga cagcctacaa cactgattac tcattgacca gcgctgacct
     1321 gtccgccctg caaggcttta cttcccctgg aatgctgtct ctggggcagg cttcagcctg
     1381 gcagcagcac catctaggac aagcggccct cagctctcta gtggctggag ggcagttatc
     1441 tcagggttca aatttgtcca ttaacaccaa ccagaacatc aacattaagt cagagccaat
     1501 ttcacctccc cgtgatagaa tgaccccatc aggcttccag cagcagcagc agcagcagcc
     1561 acagcagcaa ccaccgccac aacctccaca gccccagccc caaccccggc aggaaatggg
     1621 gcgctcccct gtggacagtc tgagcagctc tagcagctcc tacgatggca gtgaccggga
     1681 ggatccacgg ggcgacttcc attctccaat tgtgcttggc cgacctccaa atgctgagga
     1741 cagagaaagc ccctctgtaa aacgcatgag gatggacaca tgggtgacct aaggcttcct
     1801 ggttcatgtc tgttctttgt gttactgcag tgaactgccc tacatatctt aaattggtga
     1861 ataaggacat gagttcaata tatttatatg tacatgcata catatatatc cctttacata
     1921 tatatgtatg tcggtgtgag tgtgtgtatg tgtgggtgtg tgttgcatac acagaatcag
     1981 gcacttactg cgactccttg taggtatgca gatgtgtgca cacggcacac agagcacctt
     2041 gtagagacag accagcctgg cacttccttg gactacttgt ctcctaagat aaagtttttg
     2101 cagagaaacg tgtacccata tataattctt ccacattagc ctgcagaaac ctaggggccc
     2161 ctatttgttt tatttacctg tgcggtgact gtagttactt caaaaaaaaa aaaaattgct
     2221 ttgtagaaca gagcagtaga aaagcaggaa ccaagaaagc aatactgtac ataaagtcat
     2281 ttatattaat aacccaacct ggcatgggtc tattgcagag gggtgcatgg gcaagggctg
     2341 tctatattaa acagacacag taaacaaaga gccccacaca taactgtttt gcacgtgcaa
     2401 aaaaatgtat tgggtcaaag aagtgatttt tagctattaa aaagagagaa tagaaaacac
     2461 gcatgaaata ttcagaaata ctagcctaga aatatagagc attaacaaaa taaaattaat
     2521 atattaagtt ataattggaa tatgtcagaa gtttctttta cattcatatc tttaaaaatt
     2581 aaagaaactg attttaggtc atgtatattt tatatgaaag aaaacaccct taatgaattg
     2641 atgactatat ataaaattat atccactact tttgaacaca ttctgctgaa ttatttatat
     2701 aagccaaagc tgtatgttgt aacttttttt tttaaagaat agctttatct tgttttaact
     2761 ttttagtttt attttaagag ggaagaaaaa aacaaaaata tcttgcaagc agaaccttgg
     2821 aaaaaaaaaa gccatgaaca ttattattct atatgtaaat taaaagtcga gccaaactct
     2881 ttgtgtatat agcatcttaa atatattacc acctttgatg taagtaccta tgtattgtat
     2941 ggtcaccaga ttaaaaagta tatttttgtg gattgccacc aatttggggg gaaaggcgaa
     3001 gtccttaagt agagtattca ctgtttaata tttactattt tgttaaatat actgtacttt
     3061 ggattttaat tattagccca gtttttcaga ggattgtgta aaggggtttc ccctcactgg
     3121 tggtgaatgt gtgatgttct gttgtaatct ttgtgctgta tggggtgagc atcattatat
     3181 attttatatg tgtacataaa tagcaaagtg gcaaaaaaat tggtgttaag ttcatcctgc
     3241 ataaatataa aatgtgttgt aacagatttt ataaggcatt atttaaaact tgccttttgt
     3301 gagggaaaaa aaaaaacagt agaaagatga cctaatttaa ctaatattag agaaaatggc
     3361 tgagtagtag atgagcacaa aggttttata agtggtaaat aattaggaaa atatttgtag
     3421 gggaagggat cttttctcct tgactctaaa gatagaatga tgcagctggt tacaaaatcc
     3481 aggagggctt tagcgtcccg tgcgtgggaa ggcacgggcg tgcagggagc agctctccta
     3541 tggtgcagat ccccgacaca attcttgctg tcctgacgga aactggtgcc accctcagct
     3601 tggattttga acaaggcctt actcttacag ggagacagct cgttggtgat ggcaagttca
     3661 tccgtttact gggcttgtgc catgaacaaa attcaaagtc ctgtatatct tttatcctag
     3721 atttttaaat actccttttc ctgaaaaaac ttaaagagtt taaaaatggc tgctatttta
     3781 tactgaacaa tgttgagcag ctacctgcag tttttactta cattttgctt ttcccctcga
     3841 ttccctaaat tatgctcctt ttgatgtctc ctcatctgct gtcccgacag ctcatcagcc
     3901 aggtttcctg cctggccgca cacaggtatt cggtccatgc accgtggtga gcacaggctg
     3961 tgcactggag agcctcactg acagtctggg tagcacatgt tagtggaagc caaggaagtg
     4021 gggacggtgt ctcatctcct ctgtggtctc agcacttggc tcttcctcag agaaggttag
     4081 gttttcttcc tcaagtgtac tgagttgact tacaggcacg ttcctcataa ggtcacagtc
     4141 tcccaacact gactttccaa gatacccctt accactttgt aaaccattta tagctttgaa
     4201 agtattaagt gaccctttca ttattattta tgcatgttca tgaacttctg ctgtatattg
     4261 ggataggagt taacacattc acatttactg tctattttct tgtgtgcctt atgagatggc
     4321 ttctctgact gtatctcaat agtctttcta tgcaggttta taatcagtac aactactgtt
     4381 ttctaaagga atattacaca cggctcggag tttgtactta aattacactg accaagtcac
     4441 aatgtattcc gttttcagga actgaatatc tgactgttaa tcttttccca tatgcccagt
     4501 gtgatctgga gcatatgggt ctgacatcct tcacccagat gctcatgtgt gaacacatcc
     4561 acatccacag ctctcagtgg aagccagcct agagtaggga ggacactgac ggtgttgctt
     4621 taaactgact tttcttaccc tttgagactc atgtgttttg tataagacac catcacaaga
     4681 aagttttctc ccttcagata acatatttta ttattaaaaa gaaaaacaaa aaaagctttt
     4741 aagttgcact ggacgtgggc cgttccttcg gaactctttg gatctacact gagagtgagt
     4801 gtcgccgctc tgtgaacaca ggtggtccca gtcaaaactc catcctttga gccctaatta
     4861 catccattgt gttacaaaac taaatcaggg gtttgttcta aaagaacaat acatgtctca
     4921 ccatttcctt tcaactgtaa agacgactga taatgtatta acataatttc tgtattaacc
     4981 atcatgcgca caagaaatac atagtaaata cggaacctga aaactcctgc atcggatcat
     5041 aaaagctaga tgattagaat gtgaaaagaa ctttacagat gtaaaacttt tatttctctg
     5101 tagaaacttt cttcactttg ctgtgcaaga agacactgct ttgctatatt taaaatggct
     5161 tttttaaaaa gagatttatg tatttggtaa atgtttgtag tcaacagttc acacaaagaa
     5221 gctgtacacg gtttgatcat gtaaaaccgt ttggcggcac aagctggact ttgttgccat
     5281 ccttgagatg aaccttttaa gaaaaataag ttaatctcaa tttttccctg aatgtgttgt
     5341 tttttcttca ttatacaata aatattatag tgaagttttt atcaaatggt taagacaatg
     5401 ctagaggttg ttgtaagcta tttgtctcct gcactcactc cagtaaagat ggcctggctt
     5461 tgaccata
//
LOCUS       NM_001106160            5479 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus trafficking protein particle complex subunit 8
            (Trappc8), transcript variant 1, mRNA.
ACCESSION   NM_001106160 XM_001053125 XM_214614
VERSION     NM_001106160.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5479)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001106160.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.226276.1,
                                           SRR26643287.34499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               JAXUCZ010000018.1  12454866-12455365   c
            501-695             JAXUCZ010000018.1  12442598-12442792   c
            696-785             JAXUCZ010000018.1  12433518-12433607   c
            786-960             JAXUCZ010000018.1  12432885-12433059   c
            961-1114            JAXUCZ010000018.1  12430131-12430284   c
            1115-1208           JAXUCZ010000018.1  12427994-12428087   c
            1209-1465           JAXUCZ010000018.1  12425874-12426130   c
            1466-1581           JAXUCZ010000018.1  12424974-12425089   c
            1582-1732           JAXUCZ010000018.1  12423362-12423512   c
            1733-1833           JAXUCZ010000018.1  12421992-12422092   c
            1834-1939           JAXUCZ010000018.1  12419690-12419795   c
            1940-2071           JAXUCZ010000018.1  12414949-12415080   c
            2072-2296           JAXUCZ010000018.1  12411582-12411806   c
            2297-2405           JAXUCZ010000018.1  12409700-12409808   c
            2406-2600           JAXUCZ010000018.1  12406067-12406261   c
            2601-2725           JAXUCZ010000018.1  12405437-12405561   c
            2726-2800           JAXUCZ010000018.1  12404566-12404640   c
            2801-2927           JAXUCZ010000018.1  12403111-12403237   c
            2928-3082           JAXUCZ010000018.1  12400790-12400944   c
            3083-3525           JAXUCZ010000018.1  12396148-12396590   c
            3526-3673           JAXUCZ010000018.1  12394455-12394602   c
            3674-3770           JAXUCZ010000018.1  12393566-12393662   c
            3771-3839           JAXUCZ010000018.1  12391995-12392063   c
            3840-3898           JAXUCZ010000018.1  12391823-12391881   c
            3899-4072           JAXUCZ010000018.1  12388345-12388518   c
            4073-4174           JAXUCZ010000018.1  12385151-12385252   c
            4175-4320           JAXUCZ010000018.1  12382387-12382532   c
            4321-4410           JAXUCZ010000018.1  12380763-12380852   c
            4411-5479           JAXUCZ010000018.1  12378825-12379893   c
FEATURES             Location/Qualifiers
     source          1..5479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5479
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="trafficking protein particle complex subunit 8"
                     /db_xref="GeneID:291750"
                     /db_xref="RGD:1309102"
     exon            1..500
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    110..112
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="upstream in-frame stop codon"
     CDS             344..4645
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trafficking protein particle complex subunit 8-like;
                     trafficking protein particle complex 8"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 8
                     isoform 1"
                     /protein_id="NP_001099630.1"
                     /db_xref="GeneID:291750"
                     /db_xref="RGD:1309102"
                     /translation="MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLK
                     PFSRLTSEVHMRDPNNQLHIIKNLKIAVSNIVTQPPQPGAIGKLLNDVVSGSQPAEGL
                     VANVITAGDYDLNISATTPWFESYRETFLQSMPASDHEFLNHYLACMLVASSAEAEPM
                     EQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVTSGDEQRAESIYEEMKQKY
                     GTQGCYLLKINSRAPNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTMTSSKNSDSN
                     LLSLDGLDNEVKDGLPDNCRVHPLQIDQCGDTPHNTDGSDHAKSASSVHETKKASTGL
                     IRGACLTLTDHDRIRQFIQEFTFRGLLPHVEKTIRQLNDQLISRKGLSRSLFSATKKW
                     FSGSKVPEKSISELKSTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
                     LNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAERCVLL
                     SAEILKSQSKYAEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKNPMVRKYAFHMIL
                     AGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAF
                     RHILINESKQSAAQQGAFLREYLYVYKNVNQLSPDGPLPQLPLPYINSSATRVFFGHD
                     RRPADGEKQAATHVSLDQEYDAESSQQWRELEEHVVAVANKGVIPSSFYPTQYCLNSY
                     SDNSRFPLAVVEEPITVEVAFRNPLKVPLLLSDLSLLWKFQPKDTSGKDTEKERVTGE
                     PEMIGTEVISEFLINSEESKVARLKLFPHHIGELHILGVVYNLGTIQGSVTVDGIGAL
                     PGCHTGKHSLGMSVRGRQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIVTEEMPLLEV
                     FFIHFPTGLLCGEIRKAYVEFVNVSQCPLTALKVVSKRPEFFTFGGNTAALTPLSPST
                     SENCSAYKTVVTASPSLGTAFVSTASSVDFGTGTGQQLEAIPVPLPDSVLLPGASVQL
                     PMWLRGPDEEGVHEINFLFYYESVKKQPKKRHRILRHTAVICTSRSLNVRATVCRSNS
                     LEDEEGRGGNMLVFVDVENTNTSEAGVKEFHMVQVSSSSKHWQLHRSVNISENRDAKL
                     ASREKGKFCFKAVRCKQKEGDKQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSE
                     LRRTQDQLPAYPEKNASEGAVRLIEKCSEVDLSIVVLWKAYVVEDNKQLILEGQHHVV
                     VRTVGKEACSHSQKQEPPEMELLKFFRPENTTVSARPSVEQLSNLIKTSLHYPESFHH
                     PFHQKSLCLVPVTLLLSNCSKAEVDVIVDLRHKTTSPEALETHGSFTWLGQTQYKLQL
                     KSQETHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIINNA"
     misc_feature    821..2155
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="ER-Golgi trafficking TRAPP I complex 85 kDa
                     subunit; Region: TRAPPC-Trs85; pfam12739"
                     /db_xref="CDD:463688"
     misc_feature    821..2155
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /note="ER-Golgi trafficking TRAPP I complex 85 kDa
                     subunit; Region: TRAPPC-Trs85; pfam12739"
                     /db_xref="CDD:463688"
     exon            501..695
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            696..785
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            786..960
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1114
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1208
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1465
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1581
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1732
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1833
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1939
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2071
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2296
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2405
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2600
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2725
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2800
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2927
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3082
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3525
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3673
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3770
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3839
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..3898
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4072
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4174
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4320
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4410
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..5479
                     /gene="Trappc8"
                     /gene_synonym="RGD1309102"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcacgt gaggcgtgct cgcagggcct gccgggaata gtactgccgg cgggtcaggg
       61 ttcggcccaa catggcggtt cctgtcggac agtgaccaag gctttgccgt agggaggact
      121 gaacggcggt ggtcggcgtc cccacctgcc agggtgggat gcaaagcctc ggagagcgct
      181 gagcggaggc agggacgggc tcaggccctc agtcgaagca gcggcggcta ctcgcagtcg
      241 gctgcaggct ccggagtggg gccgcgcccg gccgggcagg cggcggcggc tgcggcaagc
      301 tcggctccga agcggggcgg aggccgggcg cccggccgcg atcatggccc agtgcgtgca
      361 gtcggtgcag gagctcatcc ccgactcctt cgttccctgc gtcgccgcgc tgtgcagtga
      421 cgaagccgag cggctcactc gcctcaacca cctcagcttt gccgagctgc tcaagccctt
      481 ctctcgcctc acttccgaag ttcacatgag agatcctaat aatcaactgc atataattaa
      541 aaatttgaag atagcagtaa gcaacattgt cacccagcca cctcagccgg gagccattgg
      601 gaagcttttg aatgatgttg tttctggcag ccagcctgca gaaggattag tcgctaatgt
      661 gattacagca ggagattatg accttaatat cagtgctact actccatggt ttgagtctta
      721 cagagagacc tttctgcagt ccatgccagc atcagatcat gagtttctga atcactattt
      781 agcatgtatg ctggtggcat catctgctga agcagaaccc atggaacagt tttcaaagtt
      841 gtcacaggaa cagcatcgaa ttcagcacaa cagtgattat tcctacccta agtggtttat
      901 cccaaataca cttaaatatt acgtgctttt gcatgatgtg acttcaggag atgaacagag
      961 agctgaatca atttatgaag aaatgaaaca gaaatatgga actcagggtt gctatttact
     1021 taaaattaat tctcgagcac caaatcgagc atcagatgag cagataccag atccttggag
     1081 tcagtatctc cagaaaaata gtattcaaaa ccaggaatca tatgaagatg gcccttgtac
     1141 tatgacctcc agtaagaatt ctgatagtaa cttgctttca ttggatggac tagataacga
     1201 agtcaaagat ggccttccag ataactgcag agttcatcca cttcaaatag accagtgcgg
     1261 tgacactcct cataacaccg atggctcgga tcatgcaaag tctgcttctt cagtacatga
     1321 gacaaagaaa gcaagcactg gactgattcg tggtgcctgt ttaacactta ctgatcatga
     1381 tagaattcga cagtttatac aagaatttac attccgtggc cttttgccac acgtagagaa
     1441 aacaattcgt cagttaaatg atcagctaat atcaaggaaa ggtttgagtc gatctctgtt
     1501 ttctgccact aagaagtggt tcagtggcag taaagttcca gaaaagagca tcagtgagct
     1561 gaagagcacg tcggggttgt tgtatccacc agaagcacct gagcttcaga tcaggaagat
     1621 ggcggacttg tgctttttgg tgcaacacta tgatttggcc tacagttgct atcacactgc
     1681 aaagaaggac tttcttaatg atcaagccat gctttatgca gcaggtgcct tggaaatggc
     1741 agcagtgtca gcctttcttc agcctggagc tcccaggccg taccctgctc attacatgga
     1801 cacagcaatt cagacatata gggatatctg caagaatatg gtgctggctg aaagatgtgt
     1861 gttgcttagt gccgaaattt taaaaagtca aagcaagtac gcagaggctg cagctcttct
     1921 aatacggttg acaagcgagg attctgatct ccgaagtgca cttcttttgg aacaggctgc
     1981 acattgtttc ataaacatga agaaccccat ggttagaaaa tacgcatttc acatgatcct
     2041 ggcaggccac cgttttagta aagcagggca gaaaaagcac gctttgcgct gctattgtca
     2101 agccatgcaa gtttacaaag gaaaaggctg gtctctggca gaggatcata tcaacttcac
     2161 catcgggcgc cagtcctata ctctgaggca gctggacaac gctgtttccg ctttcagaca
     2221 tattttaatc aatgaaagca agcagtctgc cgctcagcag ggagccttcc tcagagaata
     2281 tctctatgtt tataagaatg taaatcagct gtcaccagat ggccctttac cacagcttcc
     2341 cttaccatac attaacagtt cagcaacacg ggttttcttt ggccatgaca gacgaccagc
     2401 agatggtgaa aagcaagcgg ctactcatgt gagtcttgat caagagtatg acgctgagtc
     2461 gtcccagcag tggcgagaac ttgaggagca tgttgtggct gtggctaata aaggagtaat
     2521 cccatccagt ttctatccta cacagtattg cttgaacagt tactccgata actccagatt
     2581 tccactggca gttgtagaag agccaattac tgtggaagtg gcttttagaa accctttaaa
     2641 agttccgctt ttgctgtctg atttgtcatt gctctggaag tttcagccta aagacaccag
     2701 tgggaaagac actgaaaaag aacgagttac aggtgaacct gaaatgattg gaactgaagt
     2761 tatttcagaa tttttaatta acagtgaaga atctaaagtg gcaagactga agctctttcc
     2821 ccatcacata ggggagctgc acatcctggg agttgtgtat aatcttggca ctattcaggg
     2881 ctccgtgaca gtagatggca ttggtgctct tcctggatgt cacacaggaa aacattctct
     2941 gggtatgtcc gtccgaggga gacaggattt agaaattcaa ggccctcgac ttaacaacac
     3001 caaggaggag aagacgtctg ttaagtatgg ccctgaccga cgtttggacc ccatagtcac
     3061 ggaagagatg ccgctcctgg aggtgttctt tatacatttt cctacaggtc tcctctgtgg
     3121 agaaatccga aaagcatatg tagagtttgt caatgtcagc cagtgtcctc tgactgcatt
     3181 gaaagtggta tctaaacgtc ccgagttctt cacttttggt ggcaatactg ctgctctaac
     3241 accgctgagc ccctccacat ctgagaactg cagtgcctat aagacggttg tgacagcgtc
     3301 cccctccttg gggacagcat ttgtgtcaac agcatcatct gtggacttcg gaactggcac
     3361 aggacagcag ctggaggcca ttcctgtccc ccttcctgac tctgtgctac tccctggagc
     3421 ttctgtccag ctgccaatgt ggcttcgtgg gccagacgaa gaaggtgtcc atgaaattaa
     3481 ctttttattt tactatgaaa gtgttaaaaa gcagcccaaa aaacgacaca gaatattaag
     3541 acacactgca gttatttgca ctagccggtc tttgaacgtg cgagcgactg tttgtagaag
     3601 taattccctt gaagacgaag aaggcagggg cggcaatatg ctagtcttcg tggatgtaga
     3661 aaataccaat actagtgaag cgggagttaa ggagttccac atggtgcagg tgtcaagtag
     3721 cagcaagcac tggcagctac acagatccgt gaacatctcc gaaaacagag atgccaaact
     3781 tgccagtaga gagaagggaa agttttgctt caaggcagta agatgtaaac aaaaggaagg
     3841 tgataaacag tcctcagaaa aatacacttt tgcagatatc atctttggaa atgaacagat
     3901 aataagttca gcaagtccat gtgcagattt cttttaccga agtttatcct cagagttgag
     3961 aagaacacaa gaccagcttc ccgcctatcc cgagaaaaat gcctcagagg gtgctgtcag
     4021 gctgattgag aagtgcagtg aggtggacct gagcattgtc gtcctgtgga aggcatacgt
     4081 tgtggaagat aacaagcagc ttattttaga aggccagcat catgttgtcg ttcgcactgt
     4141 tggcaaagaa gcctgttcac actctcagaa acaggagcca ccagaaatgg aactattaaa
     4201 gttttttagg ccagaaaaca ctacagtttc tgcaagacca tcagtagagc agctttctaa
     4261 tctcattaaa acaagtctcc actacccgga gtcatttcat catccatttc atcagaaaag
     4321 cctttgctta gtgccagtca cccttttact ttctaactgt tctaaggctg aggtagatgt
     4381 aatagttgat ctccggcata aaacaacaag tccagaggca ttggaaactc acggatcatt
     4441 cacatggctt ggacagacac agtataaact ccagctgaaa agccaagaga cgcacagttt
     4501 gcagctgaag gcatgctttg ttcatacagg cgtttataac cttggaactc caagggtatt
     4561 cgccaagtta tcggaccagg tgacagtatt tgaaacaagt cagcagaact ccatgcctgc
     4621 tttgattatc atcaataacg cgtgacagcc gagagtcaca gactcagtct gactttgtgg
     4681 agttggtttt acaacagcgt ttgaaatacc caacttgttc aggaagttct ctgatcactg
     4741 caaaacacag gggcttggca cttagctgac acagtatgct gggctgagaa tgcttagact
     4801 cccccttttt ttttcccctt ttaaacctgg taataattta catgcttata atacagaatt
     4861 caatgtatcc atacacctta agccttaagt cttaaaaaaa cgtccaagtc tgttgcaact
     4921 taacggatgg ttgtgactct taggagtggt tttgaggaat gaaaggcctt gctggtaata
     4981 ctcctgttaa gccatttacc acttaccttt actgtgaaat tctagagagt gttaaataca
     5041 gattgtcctg ccttgcccca gacagtcctg tgagatgggt tttgaacttc ggttgtggac
     5101 actcatactt cagtgtggtg tcctctggct tatacataac tgtaaaaaag cttttctgat
     5161 gctttgaaca tagttttgga aggagtttga ctttattccc ttgctcatct cttactgtca
     5221 cactatttca caataagatt tttgtcatta aatcatattc tttattataa ctaacaatta
     5281 agttgatctg tttaaaatat aaatctactc cagttaaaaa taagcttttc aaaaatgtat
     5341 tatatttata acaaatttac tgtaaataga ataaagacat actattcact gtataaattt
     5401 attagatgcc ttttttaaaa cctgctttgt gaggacttca tatattcttt atttaaaata
     5461 aagtcagacg tgtacagta
//
LOCUS       NM_001106375            3515 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus 3'-phosphoadenosine 5'-phosphosulfate synthase 2
            (Papss2), mRNA.
ACCESSION   NM_001106375 XM_001079800 XM_215288
VERSION     NM_001106375.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3515)
  AUTHORS   Kurima,K., Singh,B. and Schwartz,N.B.
  TITLE     Genomic organization of the mouse and human genes encoding the ATP
            sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2
  JOURNAL   J Biol Chem 274 (47), 33306-33312 (1999)
   PUBMED   10559207
REFERENCE   2  (bases 1 to 3515)
  AUTHORS   Rusiniak,M.E., O'Brien,E.P., Novak,E.K., Barone,S.M., McGarry,M.P.,
            Reddington,M. and Swank,R.T.
  TITLE     Molecular markers near the mouse brachymorphic (bm) gene, which
            affects connective tissues and bleeding time
  JOURNAL   Mamm Genome 7 (2), 98-102 (1996)
   PUBMED   8835524
REFERENCE   3  (bases 1 to 3515)
  AUTHORS   Johnson,D.R.
  TITLE     The growth of femur and tibia in three genetically distinct
            chondrodystrophic mutants of the house mouse
  JOURNAL   J Anat 125 (Pt 2), 267-275 (1978)
   PUBMED   624676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced NM_001106375.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169061.1, SRR26643429.5407.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000001.1  239867689-239867774
            87-201              JAXUCZ010000001.1  239917588-239917702
            202-437             JAXUCZ010000001.1  239920887-239921122
            438-576             JAXUCZ010000001.1  239922057-239922195
            577-695             JAXUCZ010000001.1  239922710-239922828
            696-809             JAXUCZ010000001.1  239922973-239923086
            810-921             JAXUCZ010000001.1  239925089-239925200
            922-1127            JAXUCZ010000001.1  239935261-239935466
            1128-1263           JAXUCZ010000001.1  239945540-239945675
            1264-1532           JAXUCZ010000001.1  239948252-239948520
            1533-1762           JAXUCZ010000001.1  239949563-239949792
            1763-3515           JAXUCZ010000001.1  239950862-239952614
FEATURES             Location/Qualifiers
     source          1..3515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3515
                     /gene="Papss2"
                     /note="3'-phosphoadenosine 5'-phosphosulfate synthase 2"
                     /db_xref="GeneID:294103"
                     /db_xref="RGD:1307012"
     exon            1..86
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1904
                     /gene="Papss2"
                     /codon_start=1
                     /product="bifunctional 3'-phosphoadenosine
                     5'-phosphosulfate synthase 2"
                     /protein_id="NP_001099845.2"
                     /db_xref="GeneID:294103"
                     /db_xref="RGD:1307012"
                     /translation="MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTV
                     WLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRI
                     AEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVK
                     GLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHT
                     TIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEY
                     LQTLHFDTLLDDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYE
                     HRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLEL
                     KQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDD
                     DVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYI
                     VGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDP
                     ARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN"
     misc_feature    123..707
                     /gene="Papss2"
                     /note="Adenylylsulfate kinase or related kinase [Inorganic
                     ion transport and metabolism]; Region: CysC; COG0529"
                     /db_xref="CDD:440295"
     misc_feature    123..707
                     /gene="Papss2"
                     /note="Adenylylsulfate kinase or related kinase [Inorganic
                     ion transport and metabolism]; Region: CysC; COG0529"
                     /db_xref="CDD:440295"
     misc_feature    786..1877
                     /gene="Papss2"
                     /note="ATP-sulfurylase; Region: ATPS; cd00517"
                     /db_xref="CDD:173895"
     misc_feature    786..1877
                     /gene="Papss2"
                     /note="ATP-sulfurylase; Region: ATPS; cd00517"
                     /db_xref="CDD:173895"
     misc_feature    order(1278..1292,1308..1310,1317..1319,1509..1511,
                     1584..1592,1596..1601,1707..1715)
                     /gene="Papss2"
                     /note="active site"
                     /db_xref="CDD:173895"
     misc_feature    order(1278..1292,1308..1310,1317..1319,1509..1511,
                     1584..1592,1596..1601,1707..1715)
                     /gene="Papss2"
                     /note="active site"
                     /db_xref="CDD:173895"
     misc_feature    1299..1310
                     /gene="Papss2"
                     /note="HXXH motif; other site"
                     /db_xref="CDD:173895"
     misc_feature    1299..1310
                     /gene="Papss2"
                     /note="HXXH motif; other site"
                     /db_xref="CDD:173895"
     misc_feature    1392..1424
                     /gene="Papss2"
                     /note="flexible loop; other site"
                     /db_xref="CDD:173895"
     misc_feature    1392..1424
                     /gene="Papss2"
                     /note="flexible loop; other site"
                     /db_xref="CDD:173895"
     exon            87..201
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..437
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..576
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..695
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..809
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..921
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1127
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1263
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1532
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1762
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..3515
                     /gene="Papss2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaccgcc gccatccacg tctctgcacc ctggacccgg gctccgtccc agccgcagca
       61 tgtcggagat caagaagcag aagacggacc agcaaaaatc caccaatgtg gtctaccagg
      121 cccatcatgt gagcaggaac aagagaggac aggtggttgg aaccagagga ggattcagag
      181 gatgtaccgt gtggctaaca ggtctctccg gcgctggaaa aacaaccata agcttcgctt
      241 tggaggagta ccttgtgtct catgccatcc cgtgttactc cctggatgga gacaatgtcc
      301 gtcatggcct taacaagaac ctgggattct ctgccgggga ccgagaagag aatatccgtc
      361 gaattgcaga ggtggccaag ctctttgctg atgctggcct agtgtgcatt accagtttta
      421 tttctccatt tgcaaaggat cgtgagaatg cccgcaaaat ccacgaatca gcaggactcc
      481 ccttctttga gatctttgta gatgcacctt taaatatctg tgaaagccga gatgtaaaag
      541 gactctacaa acgcgctcgg gcaggagaga ttaaagggtt tacaggcatc gattccaatt
      601 atgagaaacc cgagactcca gagtgtgtgc tgaagaccaa cttgtcctca gtgagcgact
      661 gtgtgcagca ggtggtggag cttctgcaag agcagagcat tgttccccac accaccatca
      721 aaggcatcca tgaactcttt gtgccggaaa acaaaattga tcaaatccga gctgagttag
      781 agactctccc atcactacca attaccaagc tggatctgca gtgggtgcag attctgagcg
      841 aaggctgggc cactccgctc aaaggcttta tgagggaaaa ggagtacttg caaactctgc
      901 acttcgacac cctactggac gatggagtca tcaacatgag cattcccatc gtactgcctg
      961 tttctgggga tgacaaggca cggctcgaag gctgcagcaa gtttgccttg atgtacgaag
     1021 gccggagggt agctctctta caagaccctg aattctatga gcataggaaa gaggagcgtt
     1081 gttctcgtgt gtggggaaca gccagtgcaa aacaccccca tatcaaaatg gtgatggaag
     1141 gtggggactg gcttgttggt ggagaccttc aggtgctaga gagaatacgg tggaatgatg
     1201 ggctggacca gtaccgcctg acgcctctag agctcaaaca gaagtgtaaa gacatggatg
     1261 ctgatgccgt gtttgcgttc cagttacgca atcctgtcca caacggccac gctctgctga
     1321 tgcaagacac ccggcgcagg ctcctggaga ggggctacaa gcacccggtc ctcctgctgc
     1381 accctctcgg gggctggacc aaggacgatg acgtacctct cgactggagg atgaaacagc
     1441 atgcggctgt gctggaggaa gggatcctgg atcccaagtc gactattgtc gccatcttcc
     1501 catctcctat gttatacgct gggcctacag aggtccagtg gcactgcagg tgccgaatga
     1561 ttgcaggggc caatttctac atcgtgggta gggatcctgc aggaatgcct caccctgaga
     1621 caaagaaaga cctatacgaa cctacccatg gtggtaaggt cttgagcatg gcccctggcc
     1681 tcacctctgt ggaaatcatt ccattccgag tggctgccta caataaaatt aagaaggcca
     1741 tggactttta tgatccggca aggcacgatg agtttgactt catctcagga actcgtatga
     1801 ggaagctcgc ccgggaagga gaagatcccc cagatggctt catggccccc aaagcatgga
     1861 aagtgttgac agattattac aggtctctgg agaagatcaa ctaggtgctc ccggctctgg
     1921 tttctttctc aagtgctcta tgacgatttt tttctatttt tgtgattagc ggctctgtat
     1981 ccaattgctt cttgatgact ttttaaagtt agtattttgc aatgaagtaa aaagttgtgt
     2041 ctataattta aaaccaactt cattatgtct atgaaactca cactggagac taagtcttag
     2101 gtgaaaacat tgttgtacat tccagaatga aagcacttgt atactacttc atctcagcat
     2161 atatgtctca gatttcttaa aaatgtgact acatgtctag ctgacttgcc caggacagaa
     2221 tcatactttc tggcttactt ttgccagcct ggaattctaa tgtcaccaaa cacacacaca
     2281 cacacacaca cacacacaca cacacacaca cacacacaca cagacacaca cacacacaca
     2341 cacacacaca cacacagagt catcttgaag gaaatgtttc atatcaggac tttttacttc
     2401 gtgactacac atggcctcac tgcccaatgt atgagatgaa gatgaatgaa actggaagga
     2461 aaatatgtgt gaagatgcga actaaatctt aaagatgtct gtaacgtacg tctgccatga
     2521 aaatagaaag agacgtgcta gtggccgtct atgaatagta actccagtgg gaaggcactt
     2581 ttcaaaagca tggtatgtat gctttggtca aaagatttct cccagggact aaaccatcag
     2641 ggttacattg tagactactt tccccagact tgctgtggtc atagttatct tagaggcacc
     2701 tatttgatcg ctgtagtcaa aaccaaccca catactaaac taatgagaag ctaaaacctg
     2761 atttctgtag aaaagataaa gtccaaacat cttcatccta gataaaatct ccattcttcc
     2821 atatcagctt tgagagctgc tgagcactgt aatacaccac actgacatta gcaaatactc
     2881 ctgacactca aaggctgccc ggactaccac cctcctaagc taggtccctt cctccccaca
     2941 acacaggaac aggttctgat tccttgaagc tacttaatga agctctcctt gaggatgcta
     3001 aaagcaacca ccttggagac agaaggttca gggcatccta aactcttgat gttacaagtt
     3061 tccagaatgg acctgttcga cgtcctttga cggtttattt tctaagaggg aattttgata
     3121 ttttatgcat ggttcactgt tgcccaggga tacgtaaaag aaaaaatacc tttacataca
     3181 ggtgtctttg gaagagacca cagactgaag agaaactgat ttttttcata ctgccacgtt
     3241 tttagaatac tagtaagagc tcttttgaga gtaagttaca taccgtgacc acagcgagtg
     3301 agtcttcaac tgttagtgcc tgtgctcact taggccggag ttactcattg ctgcctttaa
     3361 aactgtgtgt tcactgaaaa cacgacaggg ctgcagtgcc ttaccaaatg gagtgagatt
     3421 ctaaagacag taaagtgcct ttctgctcta acagttggtg tgactgtttc agtgtcccgc
     3481 tgatacttgt tcttcaataa atctctcaaa gacca
//
LOCUS       NM_001270416            1018 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus stem-loop binding protein like (Slbpl),
            transcript variant 1, mRNA.
ACCESSION   NM_001270416 XM_002728533 XM_003753034
VERSION     NM_001270416.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Thelie,A., Pascal,G., Angulo,L., Perreau,C., Papillier,P. and
            Dalbies-Tran,R.
  TITLE     An oocyte-preferential histone mRNA stem-loop-binding protein like
            is expressed in several mammalian species
  JOURNAL   Mol Reprod Dev 79 (6), 380-391 (2012)
   PUBMED   22467188
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001270416.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ361072.1, SRR26360181.310743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000018.1  26630518-26630719
            203-305             JAXUCZ010000018.1  26630832-26630934
            306-407             JAXUCZ010000018.1  26634060-26634161
            408-512             JAXUCZ010000018.1  26634269-26634373
            513-665             JAXUCZ010000018.1  26635446-26635598
            666-786             JAXUCZ010000018.1  26635726-26635846
            787-1018            JAXUCZ010000018.1  26637463-26637694
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1018
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="stem-loop binding protein like"
                     /db_xref="GeneID:100363294"
                     /db_xref="RGD:2323347"
     exon            1..202
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..305
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="upstream in-frame stop codon"
     exon            306..407
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..852
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="isoform 1 is encoded by transcript variant 1; stem
                     loop binding protein 2"
                     /codon_start=1
                     /product="uncharacterized protein LOC100363294 isoform 1"
                     /protein_id="NP_001257345.2"
                     /db_xref="GeneID:100363294"
                     /db_xref="RGD:2323347"
                     /translation="MSLSSRMEMVSVGVTTEPCHARWEVETDEVVLRRRQKQIDYGKC
                     TPGYQSFLQQVPRAQRQPGFHPQTPNKNRRYSRRSWDAQIRQWRRALHTWDPPSQPLH
                     DRQAEGKAAGNFLRPVDTAPLDDLLDNWPQDPESSENWDRGEKEAQFAYLKVPASCPP
                     QLKDELLHH"
     misc_feature    421..630
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="Histone RNA hairpin-binding protein RNA-binding
                     domain; Region: SLBP_RNA_bind; pfam15247"
                     /db_xref="CDD:464587"
     misc_feature    421..630
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /note="Histone RNA hairpin-binding protein RNA-binding
                     domain; Region: SLBP_RNA_bind; pfam15247"
                     /db_xref="CDD:464587"
     exon            408..512
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..665
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..786
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1018
                     /gene="Slbpl"
                     /gene_synonym="SLBP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actacatttt tcctgcactc aattgtctcc gccccagcaa ccccgggaga tttaaattga
       61 gtccccttaa tattgccaat cttgaggaac tgttttggag tcaagtgttc gcttctcctt
      121 gcttctttct cttgggtttt gttacctttc ggctggaaat ggagctcctg ccaccggtgt
      181 gacagtggtt ggggcatgac aggagggttt catgcctata atcccagcac ttagaagact
      241 gtaatcgaag agtcgccgtg agtttgagga catcccgcag tgagtccaga tcgccgtggg
      301 ctagactgca gaagctgctt ccccagaaag aaggtgtgtg aaatgtcttt gtcctctagg
      361 atggagatgg taagtgtggg agtcaccaca gagccttgtc atgccaggtg ggaagttgag
      421 acagatgaag tggtcctgag gcggcggcag aagcagatag actatggcaa gtgcacacct
      481 gggtaccaga gctttctgca gcaggtcccc agggcacagc gacagccggg ttttcaccct
      541 caaacaccaa acaaaaacag gaggtacagc cgcagatcct gggatgccca gatcaggcag
      601 tggagaagag ccctgcatac ctgggacccc ccaagccagc ctctccatga cagacaggct
      661 gaagggaagg cagcagggaa cttcctaagg ccagtggata ctgctccttt agatgatctc
      721 ctggataact ggccccagga cccagaatcc tcagagaatt gggacagagg cgagaaagag
      781 gcccagtttg catacttgaa ggttcctgct tcctgccctc cccagctcaa agatgaactt
      841 ctccatcact aagtctgctg ctgtttacct atcccagaca aggggggatt caaagcattc
      901 acagcgaaca ctttattttt agggatttgc tgctacaact gtataataat gaaatgactg
      961 gaattacttt ttttttaatt accactttaa ccgattaaaa aagaaatcta aaactcca
//
LOCUS       NM_001437529            3457 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 14 (Rnf14), transcript
            variant 4, mRNA.
ACCESSION   NM_001437529 XM_006254637
VERSION     NM_001437529.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3457)
  AUTHORS   Xu,K., Shimelis,H., Linn,D.E., Jiang,R., Yang,X., Sun,F., Guo,Z.,
            Chen,H., Li,W., Chen,H., Kong,X., Melamed,J., Fang,S., Xiao,Z.,
            Veenstra,T.D. and Qiu,Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   2  (bases 1 to 3457)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254637.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.73789.1,
                                           SRR26643299.62597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               JAXUCZ010000018.1  30382855-30383436
            583-752             JAXUCZ010000018.1  30385958-30386127
            753-914             JAXUCZ010000018.1  30386679-30386840
            915-1066            JAXUCZ010000018.1  30387819-30387970
            1067-1609           JAXUCZ010000018.1  30394747-30395289
            1610-1838           JAXUCZ010000018.1  30396391-30396619
            1839-2011           JAXUCZ010000018.1  30399772-30399944
            2012-2142           JAXUCZ010000018.1  30401686-30401816
            2143-3457           JAXUCZ010000018.1  30405545-30406859
FEATURES             Location/Qualifiers
     source          1..3457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..3457
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
     exon            1..582
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            583..752
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    701..703
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="upstream in-frame stop codon"
     exon            753..914
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     CDS             761..2200
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 4;
                     androgen receptor associated protein 54; triad2 protein;
                     E3 ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 1"
                     /protein_id="NP_001424458.1"
                     /db_xref="GeneID:619577"
                     /db_xref="RGD:1589576"
                     /translation="MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTA
                     QASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCF
                     NSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCS
                     SVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAIC
                     SSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKA
                     LEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKH
                     FTDPDSPCFNRLFHAVDVNGDIWEDEIED"
     misc_feature    785..1165
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    785..1165
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RWD domain of RING finger protein 14 (RNF14) and
                     related proteins; Region: RWD_RNF14; cd23820"
                     /db_xref="CDD:467656"
     misc_feature    1412..1588
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1412..1588
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 14 (RNF14) and similar proteins; Region:
                     RING-HC_RBR_RNF14; cd16628"
                     /db_xref="CDD:438290"
     misc_feature    1673..1843
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1673..1843
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="BRcat domain found in RING finger protein 14
                     (RNF14); Region: BRcat_RBR_RNF14; cd20341"
                     /db_xref="CDD:439002"
     misc_feature    1940..2143
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     misc_feature    1940..2143
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /note="Rcat domain found in RING finger protein 14
                     (RNF14); Region: Rcat_RBR_RNF14; cd20354"
                     /db_xref="CDD:439015"
     exon            915..1066
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1609
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1838
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2011
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2142
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..3457
                     /gene="Rnf14"
                     /gene_synonym="ARA54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggtgcc cggtgactgc aggcctggct ggctagcgtg ttgcgagggc cccagtcaag
       61 ggcatactgc ggaactttcg ggcccggctc agctaagcgg ccggaaggta cggcggggag
      121 gcgctgtgag cgcgcgaggc cgagccgagt ggccgggcct gctctgtgga cactcggctc
      181 cctgcccggg acagagcggg gaggccggct ccgtgggccc tgagggtaca gggcggggcg
      241 gatgggccct gcggctgccg cacgcccggg gaacagttcc tctacgccat tgctagcccc
      301 gggcctatag ccctgcctga tcctgtcggg tgttgcttgg gagtcgtaca aatacgtctg
      361 catggcgatt ggcagactgc ggagagagag acccaggctg accccagcgc tggagcctgc
      421 agggagtggc cgggaagatg aataggattt tcccaagcta gggaaagctg gcggaggagg
      481 ggcttcacgt cctgctggag tggcttccgg tttgcaacag tagcataatt aaattttgtc
      541 tgtttggtgc tgccagggtt gactattgtt cccggtttac agatggcaga atttctgtag
      601 tatattggat gcaaatccca catcttggtt tcttatccag cttcagtcta gcttcactgg
      661 ctagaaaata aatgggattt gcacaaattc caagccacag tgaaataacg cttgcagcat
      721 tgatatcctt ttctcctcgt tgttactaac agaaaattca atgtcggcag aagacctgga
      781 agcccaggag gatgaactac tggccctggc aagtatttat gatggagatg agtttagaaa
      841 agcagagtct gtccaaggag gggaaaccag gatctatttg gatctgccac agaatttcaa
      901 gatattcgtg agcggcaatt caaatgagtg tctccagaat agtggctttg aatacaccat
      961 ttgctttctg ccaccacttg tgctgaactt tgaactgcca ccagattatc catcctcctc
     1021 cccaccttca ttcacactta gtggcaaatg gctgtcacca actcagctct ctgctctctg
     1081 caagcacctg gacaacctgt gggaagaaca ccgaggccgt gtggtgctgt ttgcctggat
     1141 gcagtttctt aaggaggaga cccttaccta cctgaatatt gtctctcctt ttgagctcaa
     1201 gatggggtct cagaaaaagg ttcagagaag gacaacagct caggcctctt ccaacacaga
     1261 gcttgctttg ggaggagctg ctgctgctgc tgctgcgtca gatgtagacc aagaagacag
     1321 tgtggatgag agagctgtac aggatgtaga atcattgtca agtctgatcc aggaaatctt
     1381 ggacttcaat caagatcgac agatgaagtg cttcaatagt aaactgttct tgtgcagtat
     1441 ctgtttctgt gagaagctgg ggagtgattg tatgtacttc ttggagtgca gacatgtata
     1501 ttgcaaagcc tgtctgaagg attactttga aatccagatc aaagatggtc aagttaaatg
     1561 cctcaactgt ccagaaccac agtgttcttc ggtggctact cctggtcagg tcaaagagct
     1621 ggtagaagca gacttatttg ctcgctatga ccgcctcctc ctccagtcta ctttggatct
     1681 aatggcagat gtggtgtatt gtccccgtcc atgctgccag ctccctgtga tgcaagagcc
     1741 tggtggcacc atggctatct gctccagctg caattttgcc ttctgcacct tatgcagact
     1801 gacctatcac ggggtttctc catgtaaggt aacggcagag aaattaatag acttacggaa
     1861 tgaataccta caagcagatg aagctactaa aaggttcttg gaacagaggt atggcaagag
     1921 ggtgattcag aaggccctgg aggagatgga gagtaaagac tggctggaga agaactccaa
     1981 gagctgcccc tgctgtggaa cgcccataca gaaattagac ggctgcaaca agatgacctg
     2041 tactggctgt atgcagtatt tctgctgggt ttgcatgggc tctctctcaa gagcaaaccc
     2101 ttacaaacat ttcactgatc ctgattctcc atgctttaac aggttgttcc atgccgtgga
     2161 tgtcaatgga gacatttggg aagatgagat tgaggactag ttcattcctg ctcgcaatgt
     2221 agaaatggaa tggtttgccc tgaccttctg tcaagtacac aaagagccct cgcaggatat
     2281 ttagggtacc atctattcac tcttcagtgt agaaggaaga acagggttta tattttcctt
     2341 tggttctact gattaaggca cgtacatttc catgtaacat aatctgataa aattatatgc
     2401 caaaggatca gaaatgaaaa ctatagatta aatattataa tatgcccaaa ctgtgaatag
     2461 ttaaaaagta aatatttatt ttctccccca agctttaggt tagggagagg gtcaagagtt
     2521 aagcttttag accatgtcca agaagcccct gcagctgggg acagtcacag ccccagccac
     2581 actgtcctgg gagcctgatc cattctctgt acactgctca tttccattcg tgctttggag
     2641 agagcctctg ctctgtaact gaccaaatgt ccagtgttgt tctgttgtac tgcttgccag
     2701 aatagaaatc tataataaat taaaaaatat ttttagtatt ataatccctg tgggtcactt
     2761 gatatttatg aatagtgtat tgaatcccct ggtttagagc caaatgtaga atttaggatt
     2821 ctggctcaga attcctctag attcagagtc agagctgtct gtgctccctt ttgttctcag
     2881 ctttctccct ttgcctccca ccttctgttg gcaagtacag ttttaatgtt gattacagca
     2941 gtgtgtgtct ttatttcctc tgctagaata gaaaagagcc caatatattc ctcatgaatg
     3001 ctctctgaac ctgtgaacag catcatggtt ctaccccacc ttctgaacac tcgggaattg
     3061 ggcttcctcc cctcccctcc cctcgtagac agcagtgttt ggagtgataa tagtagcttg
     3121 atagctagat tcctaaccct ggcttttatt ggctttttga aaaactgtct tcctcctgat
     3181 tccctaagtg gcttggtgta gtcacttggt ggatgttttg gaaaggacag taactcacct
     3241 gtagcttgtg aacttgtgtt ttctactgtg acattgaaaa ttaaggattg cttaactgtc
     3301 agctcaaact gttgctggat tgtcaatgag gatgcttaat cttaacaata aagtaattta
     3361 aaatcatccc gtaattggag taggcatggt gtctgttgct tctgtcacca aagcactgac
     3421 tgaattaaaa ctgactgtgt ttctgtttgt tctgtta
//
LOCUS       NM_001437327            8839 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus janus kinase and microtubule interacting protein
            2 (Jakmip2), transcript variant 4, mRNA.
ACCESSION   NM_001437327 XM_063277366
VERSION     NM_001437327.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8839)
  AUTHORS   Cruz-Garcia,D., Vazquez-Martinez,R., Peinado,J.R., Anouar,Y.,
            Tonon,M.C., Vaudry,H., Castano,J.P. and Malagon,M.M.
  TITLE     Identification and characterization of two novel (neuro)endocrine
            long coiled-coil proteins
  JOURNAL   FEBS Lett 581 (17), 3149-3156 (2007)
   PUBMED   17572408
  REMARK    GeneRIF: NECC 1 & 2 proteins primarily expressed in
            (neuro)endocrine tissues in vertebrates thus supporting a role for
            these proteins in the regulated secretory pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277366.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.73923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000018.1  35998552-35998896   c
            346-576             JAXUCZ010000018.1  35907564-35907794   c
            577-853             JAXUCZ010000018.1  35901780-35902056   c
            854-1351            JAXUCZ010000018.1  35893106-35893603   c
            1352-1561           JAXUCZ010000018.1  35889442-35889651   c
            1562-1660           JAXUCZ010000018.1  35887501-35887599   c
            1661-1807           JAXUCZ010000018.1  35883648-35883794   c
            1808-1948           JAXUCZ010000018.1  35882878-35883018   c
            1949-2005           JAXUCZ010000018.1  35880934-35880990   c
            2006-2125           JAXUCZ010000018.1  35879957-35880076   c
            2126-2254           JAXUCZ010000018.1  35878661-35878789   c
            2255-2338           JAXUCZ010000018.1  35876787-35876870   c
            2339-2437           JAXUCZ010000018.1  35872906-35873004   c
            2438-2536           JAXUCZ010000018.1  35871950-35872048   c
            2537-2590           JAXUCZ010000018.1  35871138-35871191   c
            2591-2656           JAXUCZ010000018.1  35870288-35870353   c
            2657-2725           JAXUCZ010000018.1  35866017-35866085   c
            2726-2803           JAXUCZ010000018.1  35856809-35856886   c
            2804-3007           JAXUCZ010000018.1  35854261-35854464   c
            3008-3073           JAXUCZ010000018.1  35848371-35848436   c
            3074-3144           JAXUCZ010000018.1  35845323-35845393   c
            3145-8839           JAXUCZ010000018.1  35833986-35839680   c
FEATURES             Location/Qualifiers
     source          1..8839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..8839
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="janus kinase and microtubule interacting protein 2"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
     exon            1..345
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            346..576
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            577..853
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    713..715
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="upstream in-frame stop codon"
     CDS             725..3124
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     2 isoform 3"
                     /protein_id="NP_001424256.1"
                     /db_xref="GeneID:307479"
                     /db_xref="RGD:1559742"
                     /translation="MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKV
                     SKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSR
                     TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLK
                     TAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR
                     IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHC
                     SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLA
                     KRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL
                     KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMT
                     SFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAERE
                     AKAQEQLQAEVLRYRAKIEDLEATLAQKGQIEKQEAENHRLQQELQDARDQNELLEFR
                     NLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNL
                     RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELD
                     YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRK
                     SREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKFLFLFLFFSLAFILW
                     P"
     misc_feature    779..>2452
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    779..>2452
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    1949..2467
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    1949..2467
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="JAKMIP CC3 domain; Region: JAKMIP_CC3; pfam16034"
                     /db_xref="CDD:464986"
     misc_feature    <2150..>3070
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <2150..>3070
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            854..1351
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1561
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1660
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1807
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1948
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2005
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2125
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2254
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2338
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2437
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2536
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2590
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2656
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2725
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2803
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3007
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3073
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3144
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..8839
                     /gene="Jakmip2"
                     /gene_synonym="RGD1559742"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctaccg cagcaggggt ggggctgtgg gggtggggag ggaaggagga gcctgaggag
       61 gtgtctgctg caagttcctg gctgattctg agctcacacc atcctccaag agggaggagg
      121 ctcaagtgat gctgctgctg ttgccgcctc tactgctggt actctagtgg agctgggaag
      181 ggtggttcct atcgcaccat cgccaaccgg agagggaggg ggaaaaaaat cctggtagcc
      241 gctgctgatg ttgggttcag aggctgcatc cgacccggtc acaagaaaaa tggattcagt
      301 gtgcggctct ccctcttttc agcatcttct cctgctctca acatgtgcag tgtttgggac
      361 ttgaagatgt tcctcccttc tctcctctac tcaggattct ggttaggcct ccattacctg
      421 gaccaattca gcaacttgct cctgaatctc catgactcca ttctcttccc actctgccac
      481 cagaataacc tcaataatca cctgctagat acttaccagt caggaatttc aacacccctt
      541 gtactgctta ctggacgatg agccctacgc cctgagggct tccgaggcag cgtttgagaa
      601 gaccttagca aggaacacca agcagtagtg gctgaaacac ctcactccag gaaatgaaac
      661 agtaacatgg cagtacctgt ttgagaggat taaaacccca aaagactcca tttagaaagg
      721 gacaatgtcc aaaaaaggac gaaataaggg cgagaagccc gaggcactca ttgttgccct
      781 tcaagctgcc aatgaagacc tcaggaccaa actcacagac attcagatag aacttcatca
      841 agagaaatcc aaggtatcaa agcttgaaag agagaagact caagaagcaa agaggattcg
      901 tgagctggag cagcgcaaac acacagtcct ggtgacagag cttaaagcca agctccatga
      961 ggagaagatg aaggagctgc aggctgtgag ggagaatctc atcaagcaac atgagcagga
     1021 aatgtcaagg acagtgaagg tgcgggatgg agagattcag agactcaagt ccgctctgtg
     1081 tgctctccgc gatggcagca gtgacaaagt aaggacagca ctcaccattg aggcccggga
     1141 ggaggccagg aaacagttcg atgcagagcg cctgaagctc ctgcaggaaa ttacagactt
     1201 aaaaaccgcc aagaagcagg tggatgaggc tctgagcaat atgatccaag cggataaaat
     1261 caaggctggg gaccttagga gtgagcatca gtcccaccag gaagccatct cgaagatcaa
     1321 gtgggaatcg gaacgggata tacgaaggct gatggatgaa atcaaagcca aggacaggat
     1381 catcttctcc ctggaaaaag aactggagac tcagacaggc tatgtacaga aactccagct
     1441 acagaaagag gctttggatg agcagctctt ccttgtcaag gaggcagagt gtaacatgag
     1501 cagtccgaag agagagattc caggaagggc aggggatggc tctgaacact gcagcagccc
     1561 ggatttgcga agaaatcaaa agagaatagc cgaattgaat gccactatac gaaagttaga
     1621 agacaggaac accttgctcg gagatgaacg aaacgagttg ttaaaacgtg tgcgggaaac
     1681 tgaaaaacaa tgcaaacctc tcctggaaag gaacaagtgc ctagccaaga gaaacgatga
     1741 actgatggta tctctacaac gcatggaaga gaaattaaaa gccataacca aggaaaattc
     1801 agagatgaga gagaaaataa cgtctcaccc accattgaag aaactgaagt ctctgaatga
     1861 ccttgatcaa gctaatgaag aacaagagac ggagtttcta aaactgcagg tcattgagca
     1921 gcagaacatc attgatgagc tcaccaggga tcgagaaaaa ctcatccgta ggagaaagca
     1981 caggagaagc tcgaaaccaa tcaagaggcc tgttttagat ccgttcattg gctatgatga
     2041 ggattcgatg gattcagaaa catcatccat gacctccttt agaacagacc ggacacctgc
     2101 taccccggat gatgacttgg atgaaagtct agctgctgaa gaatctgagc tacgatttcg
     2161 acaattaaca aaagaatacc aagccctcca aagagcatat gccctcttgc aggaacagac
     2221 tggaggcatc atagatgctg aaagagaagc caaggcacaa gagcagctcc aggcagaggt
     2281 gctgaggtac agggccaaaa tcgaagattt ggaagcaacg ctggctcaga aagggcagat
     2341 agagaagcag gaagcagaga atcaccggct acagcaagaa cttcaggatg ccagagacca
     2401 gaatgagctg ctggagtttc gcaacctaga actagaagag agagagaggc gatcccctcc
     2461 attcaatcta caaattcacc ccttctcaga tggtgtgagt gcactgcaga tctactgcat
     2521 gaaagaaggt gtcaaggatg tcaacatccc tgatctcata aagcagcttg atatccttgg
     2581 tgacaacggg aatctaagga atgaagaaca ggtggccata attcaggcca gcactgtgct
     2641 gtccctggca gagaagtgga tccaacaaat tgaaggagca gaggctgccc tgcaccagaa
     2701 aatgatggaa ctggaaagtg atatggaaca attctgtaaa atcaaaggct acctggagga
     2761 agaactagac tacagaaaac aggctcttga ccaggcatat atgagaatcc aggaactaga
     2821 agctactttg tacaatgctc tgcagcaaga aactgtgatc aagttcggtg aactgttaag
     2881 tgacaagcag caagaggagt tgaggacggc tgtagaaaag ttacggcggc aaatgctgag
     2941 gaagagccgg gaatatgact gtcagatcct ccaggagagg atggagctcc tacagcaagc
     3001 tcaccagagg atccgtgacc tagaagataa aacagacatc caaaaacggc agataaagga
     3061 cctagaagaa aagtttctgt ttctattctt gttcttctct cttgccttca ttctatggcc
     3121 ttgatgtcaa ggtgcctctt aaagaaaaat caagaacttg gatcataccc caagaaggca
     3181 aatgctttta aaccttcaaa gatggcaaaa ttgtttacac cgatgtaagg gaaatcaaaa
     3241 gctaagaatt accctgtagc caagactatg agctttaaag ccattattca aggtttctta
     3301 cttgacagtt tataatgacc ctgttgaaaa atctacatta tatgctgcaa ttaatgaaac
     3361 gtgtgtatgt caaaccggaa gagaactata aacatatatt gtgggaagga aaatttcagc
     3421 agtggaacca gtttcagcag atcaaaagaa gatgtgtctt gggcatggaa ccaaagttac
     3481 aatgaaccat tcaactcctg ctgtgcaggg ggggtcattt taatgtaaca ccacacccca
     3541 tggaaacact attcctgaaa ataaacatca ttttaaaaaa aaacaaaaca aacaaaagtg
     3601 aaaaaaaaac caacttaagg gtgggcgggt aatgaagcac gaggaataat acctatgagg
     3661 aactatttac aataaaatgt ttcatttgaa aagtctggtt tcttactaca gggatttgct
     3721 tttctgtctt tatgattgtt ttaaactcag gaacagagac atctatgatg aggagggaag
     3781 aaaaatactc tccattttgt ttctccaaaa ggtggagttg gggatgagaa gtggattcta
     3841 gttactctac aagcgcagag ccaagggact ctgaggagtt taacatggag tggaattgga
     3901 aatctatgct tcctcatatc acacacctgc atctctccac catggatgga ctggtctcct
     3961 ccgtactgaa caaggtgaaa attatactca gaagtcacaa accgcctaac ttagctctgt
     4021 cgaaaacatc aagatctata gggaactagg gccaggaagc aactctgcag cttccagatt
     4081 caagttaaaa ttgcctgcag atgaatatgc tgtctgactt gtgtgaagac cccacagaaa
     4141 tgatgagaag ctgacaactg aacgtggggt tcccagagag ctgcgcatgt tgagtatccc
     4201 agagcaatct gaactcttgt cacttagaac aatagcatta ttttctgaga tcgctgtccg
     4261 caacaagacg tctctacttt tttatagaca acactgacaa gctggttctc tatcacaggc
     4321 agatagacaa ctaacacttt tcctaagtca catattacag agtattggtt tcagcaatgg
     4381 cagtaaatat atcctcctga aaagctgatt ttacacgtcc ttgactgtag ataacaaggc
     4441 aacctcaatt tctcaaatac tcaatgtttt ctttccaggt ttagaaatcc catgcatcga
     4501 gaatgtgtgt agggagccag gaactctttc tatgaaatgc tacacaaaca ggtccatatg
     4561 tgaattgagt atattctcct tcagttttaa cactggcaat ttcaaagcca gagcaactga
     4621 agaatcttca agacaaaaca gattcctggg gtcccacatt tttgtccttg tatttaatgc
     4681 tgacccaact gtttggccca gtcactgaac ctctctgtgc ctcagtttcc tcatctaaaa
     4741 aaatggggat taaatgtttt gatttttttc ctaaggtttt gtttgcaatt ctggaacaag
     4801 aggtgcttaa ggtagcacaa agtgctttgt aaccgttata aatgctgtat tatttgactt
     4861 ccctgtataa tgaaatagtt cctgagtttg attcaaacag cagagcatca ctgaagcgtc
     4921 cccatcaagc tgcctaggac attattagca ataaattgtg agattcaaaa accacaatat
     4981 tgaatctata ggaaatagat tgactcgttc tattgagaaa gacagaaagt gtgtcatttc
     5041 aatgctaagc acctcccatg ctctcctgat tgcataacat gccatcaatc gaaaccccca
     5101 acatcatcac aggagagcca accatgcaac tacggattgc caagaacaga aagcaacaaa
     5161 gaaagccgat attatttttc aaagaatgtc agatgatgtg tcctaatgca aaaactttaa
     5221 aagtcagaac tgtactaatg gattctttgt acaactaagg taagtcccag atccccgcaa
     5281 ttagcaggtt cattgtgcag gtgatgtgaa acagggtact tctcctacac cggccaccca
     5341 gctaactcag tcctgtatgg gagtacacaa acggcttgtt tactgcttca attatacttc
     5401 acctactatt ataggaccca cttgagaaaa tgcatactta atctgctccg tacatgcctt
     5461 cctcctctcc ttttgctttt cctatcgaaa acctggtggg taaattttca tatcagagaa
     5521 ctatgtctaa attattatga atgccaataa tatgctatat gttaccctgt tgttagtcaa
     5581 attgcataaa acccatgctg aactttctga gagcgaaagc cacttgagta atcatctctg
     5641 aaactttgat tggtgggagg gggaggcttt ctttctgttt aatatccaga atatcactct
     5701 agatcgtaag ctaaatgatg acatctttat caggtgttcg tcatagtcct caaaatgagt
     5761 gctctaatat ttagactagg aaagtttaaa tattttgata gagtccatat ctacgatgac
     5821 agcatcaaga aaaactggag gtgtgcgttt tgcttattca cagatgcctg agaatggttt
     5881 ctatcttagt gaatgcttcc ttgcatatga tgctcagaat agccaaaaga atgtactatt
     5941 agtaacaaag agttgtgctg tgacatcgtt tctcattttc aaaagaaaaa aaaggtaatt
     6001 cctactccag gttttaaatt ttggtatctg tacttagcta gagatttggg gggatgggca
     6061 caataagagt acacctaact actttttctt agccatgtac tcatctctct gaatcccact
     6121 gaagtagttt gagaggtgaa agcttaacac tgtcaggact tctcagattt ccataaaaga
     6181 aatgcacaga ctctatatga tatccattct acaaaacaag gtcagcaact tcagcatctt
     6241 gtcttaaatg ccatctaact tatttcagtt gaaaaattaa attagcactg tcagatcctg
     6301 tttgacttat gtcatattcg ctaaattgct gctaaaagtg aggttttaac aataaaagca
     6361 tactttgttt tgcttttttt tcccctacaa ttcagaataa gtttatatca aagtataaaa
     6421 ttcttcccaa cgttcgagat gtgcatcatc actggggtca gaaagggcct tcaattgcca
     6481 tagaagaaat aaaatttgcc aaatcatttg tgctgtggta ttttatttca aaccgttggg
     6541 gtgttttttt ctacttgaaa taaatctcac caatttttct tctgctgatt tattgctaac
     6601 tttttctaaa aacacacaat aaaatctgta tgtttataac ttaaatggaa ttgataagca
     6661 ccttctttta aaacaatgct tatcatttta acttgcctgg gttttcattg aaagctgtaa
     6721 aaagagcatc tgttggttat gttgatattt aaataactag accatctctg cgatgtcaca
     6781 tcagaataga tgaccagtgt actcagtatt aaagcatata gatgtgttct ttttatttgt
     6841 caaagaacgg aatggaatac tccctctccc tccccctctc cctccccctc tccctccccc
     6901 tctccctccc cctctccctc cccctctccc tccccctctc cctccccctc tccctccccc
     6961 tctccctccc cctccccctc tccctccccc tcccccccct ctctctctct cacacacaca
     7021 cacacacata caatatgtgt accaagacaa gatttgtaag actcagctat gttgattggc
     7081 agttgcattg cttttgtgac gcttccactg ccctctctcc ctcccccctc cactcttccc
     7141 tcctgctttt tgttttcttt tttatactgg tgctataggt tgaatccagg tgcctgggca
     7201 ttctagacag cacacagctg tatctcccca gaccccagcc ctggtaattt aatatatttt
     7261 agggattaaa tttgatctac tatatggaaa gtacataaat gtaacttttg aagtataact
     7321 tatgcaagta gctcttagat ggctgtgcca tggtgttcag gatggatgca aagccccctt
     7381 tctgcttaga tggggaaaag acataagata aagatttcct tattcccaac tgctttatac
     7441 ttttcatata gaatatgcct agagactaga ttccatactt atatacaaga ggactttcaa
     7501 tgctggaaga atggggttgt tcctcgggat gtcacttcag aactgagcaa ggcaggtttt
     7561 cttcccatcc ctgattttat cagttgagtt cctcctcaat aaatctttat tgctgagaga
     7621 gcctgagttg agttcttaat ttgactttta aaagatacat gtaaaggggc agtacaggaa
     7681 agtggactga aattcaccac attcactcta gtgtgacaaa cctgtaattg attcactgaa
     7741 gctttctggt tttattttgc tatttgattt tgtactgaaa tctttgttgt ataaagtcct
     7801 acagggcggc aatggtgcag acaaacaatg ttgagtcccc tttgcccaca tgaagactct
     7861 acaaacttac taaagaatga atgatccaat ctctcaatca gaaacagatc tggaacctgc
     7921 tataaactgc agtcacttaa gtttgacaga cacctcacaa aacgtgccta tttcccctct
     7981 taactaaacc atctctcctg aataaggcaa atcaaaatct aaacacttaa taaatacaag
     8041 atgtacatag tcatgcatat gtatcctgta cagagtatgg tggtgcaggc attaacagat
     8101 atgtacttca gacctcgaca gaagacttag agatgatgct tttctgatgt cactaggcaa
     8161 ctcgattttg tttggcgtat agtgtctata cccacccctc cttggctata tctctacctt
     8221 ccaccattac tgctatttcc tgttgcctgt gaattttcca cgaccctgtc ctctaagcag
     8281 aacgttttgt tccctagcat ctcaataaaa cgcccagcac aatttacagt attaatatca
     8341 atcaaaggtc ctatgctttt ctcaactaaa attgcatttc cagaagcttc tgtgcatgat
     8401 ctaacctata gtatttaatt ctgtgaggat ttgagtttac agggaacata tttgaatcca
     8461 caattccttg tgtatctatt gagttagtgt agccaggggg ctggtttcca aagcattcct
     8521 acgattgcct gcattagttc aggtccttcc tatcacagca tgactagtag gccacttcag
     8581 tgcttactga tgagaggcag aacttgattg aatgcagcag agggattgtc tgaggttcac
     8641 gggacaggta catgtgctgt atgtatcacc atagagatcg gaatccattt attgtatgta
     8701 aagttttatg aacggttatt ttataattta tgtatttaat atagcaatca atgaactctg
     8761 gtgttttagt ttctatgaaa aataaaacaa actgcatttt ttaaaaaaaa taaaagcttt
     8821 taccttgtgt tattcataa
//
LOCUS       NM_001436998            1162 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus Yip1 domain family, member 7 (Yipf7), transcript
            variant 2, mRNA.
ACCESSION   NM_001436998 XM_006251037
VERSION     NM_001436998.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced XM_006251037.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.34900.1,
                                           SRR26643295.48860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000014.1  38925046-38925084
            40-156              JAXUCZ010000014.1  38926496-38926612
            157-320             JAXUCZ010000014.1  38943454-38943617
            321-466             JAXUCZ010000014.1  38948134-38948279
            467-648             JAXUCZ010000014.1  38950311-38950492
            649-1162            JAXUCZ010000014.1  38952504-38953017
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1162
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Yip1 domain family, member 7"
                     /db_xref="GeneID:364147"
                     /db_xref="RGD:1310766"
     exon            1..39
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="upstream in-frame stop codon"
     exon            40..156
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..811
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /codon_start=1
                     /product="protein YIPF7"
                     /protein_id="NP_001423927.1"
                     /db_xref="GeneID:364147"
                     /db_xref="RGD:1310766"
                     /translation="MSNPEQYDMDFYQSNYIIDNQEQSYNDSNAYGNFYGSRQPQARE
                     QCQPSSPVPPEMFLSSDYGGQLFQPASNLHYYSQSSSVDSFDEEPPLLEELGINFDHI
                     WQKTLTVLNPMKPADGSIMNETDLTGPILFCVALGATLLMAGKAQFGYIYGMSAIGCF
                     GIHALLNLMSSSGVSYGCVASVLGYCLLPMVILSSCAVFFSLQGTAGTMSALLIITWC
                     SLSASKIFISALAMEGQQLLVAYPCALLYGLFALLTVF"
     misc_feature    <272..808
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Rab GTPase interacting factor, Golgi membrane
                     protein [Intracellular trafficking and secretion]; Region:
                     YIP1; cl46908"
                     /db_xref="CDD:481248"
     misc_feature    <272..808
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Rab GTPase interacting factor, Golgi membrane
                     protein [Intracellular trafficking and secretion]; Region:
                     YIP1; cl46908"
                     /db_xref="CDD:481248"
     exon            157..320
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            321..466
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            467..648
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            649..1162
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtttgttg gaggaccctc cctcatagca tacagagagg atgtcgaacc cagaacagta
       61 tgacatggac ttctaccaat caaattatat cattgataat caggagcaga gttataatga
      121 ttctaatgct tacggaaatt tctatggatc cagacaacca caagcccgtg agcagtgtca
      181 accttcctct ccagttccac cagagatgtt cttgtcatca gattatgggg gacagctttt
      241 tcagccagcg tccaacttgc attactattc acagtcttcc tcagttgaca gttttgatga
      301 agagcctcct ttgctagagg aacttggaat taattttgat cacatatggc agaaaacctt
      361 gacggtgcta aacccaatga aaccagcaga tggcagcatc atgaatgaaa cagatcttac
      421 aggacccatc cttttctgtg tggctctggg agccacgttg cttatggcag gaaaagccca
      481 gtttggttat atctatggca tgagtgccat tggctgcttt gggattcatg ccttactgaa
      541 cttgatgagc tcttcagggg tgtcgtatgg ctgtgtggcc agtgtgctag gatactgctt
      601 gctccccatg gtcatcttgt ccagctgtgc agttttcttt tcactgcagg gtaccgctgg
      661 aaccatgtca gccctgctca tcatcacctg gtgcagcctc tcagcgtcca agatcttcat
      721 ttcagccttg gccatggaag gacaacagct cctcgtcgct tacccctgtg ccttacttta
      781 tggactcttt gcccttctga cagttttcta aagactgctt ggcatggttt tgctcttcag
      841 atttttctgg aagtgtgctt tcactcagat cctgtgagat aacttccatg ttatcgccgc
      901 tgagagacta ttcagcagag agaggagaca gcgctcaatg atagtgctct gctagccggt
      961 tggtggggat gatgatgttt tgatttcttt agcctgcagc attaaaacag ttaaaacatt
     1021 tttgaaatat taagagatgc agtctccgtg ctgatagatg ctgtttttct caacagacat
     1081 gctgctgaga aattataagc aaaacaccat cctatgccta acatttatta actttgtaat
     1141 aaatattttt caaaaacttt ca
//
LOCUS       NM_001437265            6217 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ATPase phospholipid transporting 8B1 (Atp8b1),
            mRNA.
ACCESSION   NM_001437265 XM_006254842
VERSION     NM_001437265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6217)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   2  (bases 1 to 6217)
  AUTHORS   Haas,M.J., Shah,G.N., Onstead-Haas,L.M. and Mooradian,A.D.
  TITLE     Identification of ATP8B1 as a blood-brain barrier-enriched protein
  JOURNAL   Cell Mol Neurobiol 34 (4), 473-478 (2014)
   PUBMED   24643366
  REMARK    GeneRIF: ATP8B1, a P-type aminophospholipid translocase, is
            enriched in cerebral microvessels and may have a role in plasma
            membrane lipid transport
REFERENCE   3  (bases 1 to 6217)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   4  (bases 1 to 6217)
  AUTHORS   van der Velden,L.M., Wichers,C.G., van Breevoort,A.E.,
            Coleman,J.A., Molday,R.S., Berger,R., Klomp,L.W. and van de
            Graaf,S.F.
  TITLE     Heteromeric interactions required for abundance and subcellular
            localization of human CDC50 proteins and class 1 P4-ATPases
  JOURNAL   J Biol Chem 285 (51), 40088-40096 (2010)
   PUBMED   20947505
REFERENCE   5  (bases 1 to 6217)
  AUTHORS   Ray,N.B., Durairaj,L., Chen,B.B., McVerry,B.J., Ryan,A.J.,
            Donahoe,M., Waltenbaugh,A.K., O'Donnell,C.P., Henderson,F.C.,
            Etscheidt,C.A., McCoy,D.M., Agassandian,M., Hayes-Rowan,E.C.,
            Coon,T.A., Butler,P.L., Gakhar,L., Mathur,S.N., Sieren,J.C.,
            Tyurina,Y.Y., Kagan,V.E., McLennan,G. and Mallampalli,R.K.
  TITLE     Dynamic regulation of cardiolipin by the lipid pump Atp8b1
            determines the severity of lung injury in experimental pneumonia
  JOURNAL   Nat Med 16 (10), 1120-1127 (2010)
   PUBMED   20852622
REFERENCE   6  (bases 1 to 6217)
  AUTHORS   Pawlikowska,L., Groen,A., Eppens,E.F., Kunne,C., Ottenhoff,R.,
            Looije,N., Knisely,A.S., Killeen,N.P., Bull,L.N., Elferink,R.P. and
            Freimer,N.B.
  TITLE     A mouse genetic model for familial cholestasis caused by ATP8B1
            mutations reveals perturbed bile salt homeostasis but no impairment
            in bile secretion
  JOURNAL   Hum Mol Genet 13 (8), 881-892 (2004)
   PUBMED   14976163
REFERENCE   7  (bases 1 to 6217)
  AUTHORS   Eppens,E.F., van Mil,S.W., de Vree,J.M., Mok,K.S., Juijn,J.A., Oude
            Elferink,R.P., Berger,R., Houwen,R.H. and Klomp,L.W.
  TITLE     FIC1, the protein affected in two forms of hereditary cholestasis,
            is localized in the cholangiocyte and the canalicular membrane of
            the hepatocyte
  JOURNAL   J Hepatol 35 (4), 436-443 (2001)
   PUBMED   11682026
REFERENCE   8  (bases 1 to 6217)
  AUTHORS   Ujhazy,P., Ortiz,D., Misra,S., Li,S., Moseley,J., Jones,H. and
            Arias,I.M.
  TITLE     Familial intrahepatic cholestasis 1: studies of localization and
            function
  JOURNAL   Hepatology 34 (4 Pt 1), 768-775 (2001)
   PUBMED   11584374
  REMARK    Erratum:[Hepatology 2002 Jan;35(1):246]
REFERENCE   9  (bases 1 to 6217)
  AUTHORS   Tygstrup,N., Steig,B.A., Juijn,J.A., Bull,L.N. and Houwen,R.H.
  TITLE     Recurrent familial intrahepatic cholestasis in the Faeroe Islands.
            Phenotypic heterogeneity but genetic homogeneity
  JOURNAL   Hepatology 29 (2), 506-508 (1999)
   PUBMED   9918928
REFERENCE   10 (bases 1 to 6217)
  AUTHORS   Bull,L.N., van Eijk,M.J., Pawlikowska,L., DeYoung,J.A., Juijn,J.A.,
            Liao,M., Klomp,L.W., Lomri,N., Berger,R., Scharschmidt,B.F.,
            Knisely,A.S., Houwen,R.H. and Freimer,N.B.
  TITLE     A gene encoding a P-type ATPase mutated in two forms of hereditary
            cholestasis
  JOURNAL   Nat Genet 18 (3), 219-224 (1998)
   PUBMED   9500542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254842.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.63085.1,
                                           SRR26643297.50479.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000018.1  60426799-60426991   c
            194-396             JAXUCZ010000018.1  60369204-60369406   c
            397-494             JAXUCZ010000018.1  60346264-60346361   c
            495-608             JAXUCZ010000018.1  60343442-60343555   c
            609-707             JAXUCZ010000018.1  60341891-60341989   c
            708-769             JAXUCZ010000018.1  60341691-60341752   c
            770-842             JAXUCZ010000018.1  60337883-60337955   c
            843-913             JAXUCZ010000018.1  60337637-60337707   c
            914-996             JAXUCZ010000018.1  60336308-60336390   c
            997-1155            JAXUCZ010000018.1  60336035-60336193   c
            1156-1244           JAXUCZ010000018.1  60335665-60335753   c
            1245-1435           JAXUCZ010000018.1  60332286-60332476   c
            1436-1644           JAXUCZ010000018.1  60328575-60328783   c
            1645-1688           JAXUCZ010000018.1  60326458-60326501   c
            1689-1845           JAXUCZ010000018.1  60325531-60325687   c
            1846-2034           JAXUCZ010000018.1  60320250-60320438   c
            2035-2147           JAXUCZ010000018.1  60318254-60318366   c
            2148-2312           JAXUCZ010000018.1  60316290-60316454   c
            2313-2424           JAXUCZ010000018.1  60314757-60314868   c
            2425-2500           JAXUCZ010000018.1  60313487-60313562   c
            2501-2633           JAXUCZ010000018.1  60309504-60309636   c
            2634-2922           JAXUCZ010000018.1  60308402-60308690   c
            2923-3146           JAXUCZ010000018.1  60298629-60298852   c
            3147-3230           JAXUCZ010000018.1  60297673-60297756   c
            3231-3476           JAXUCZ010000018.1  60296402-60296647   c
            3477-3615           JAXUCZ010000018.1  60295949-60296087   c
            3616-3746           JAXUCZ010000018.1  60291141-60291271   c
            3747-6217           JAXUCZ010000018.1  60286605-60289075   c
FEATURES             Location/Qualifiers
     source          1..6217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6217
                     /gene="Atp8b1"
                     /note="ATPase phospholipid transporting 8B1"
                     /db_xref="GeneID:291555"
                     /db_xref="RGD:1308488"
     exon            1..193
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..396
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    195..197
                     /gene="Atp8b1"
                     /note="upstream in-frame stop codon"
     CDS             216..3971
                     /gene="Atp8b1"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IC;
                     ATPase, Class I, type 8B, member 1; ATPase,
                     aminophospholipid transporter, class I, type 8B, member 1;
                     P4-ATPase flippase complex alpha subunit ATP8B1"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase IC"
                     /protein_id="NP_001424194.1"
                     /db_xref="GeneID:291555"
                     /db_xref="RGD:1308488"
                     /translation="MNTERDSETTFDEDSQPNDEVVPYSDDETEDELEDQGPAVEPEQ
                     NRVNREVEKKKETFRKDCTWQVKANDRKFHEQPHFMNTKFFCIKESKYASNAIKTYKY
                     NALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAIKDL
                     VDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSS
                     EPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFT
                     GTLFWRNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKID
                     YLMNYMVYTIIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATPSYRGFLNFWGY
                     IIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHY
                     IFSDKTGTLTQNIMTFKKCCINGTIYGDHRDASQHSHSKIELVDFSWNEFADGKLAFY
                     DHYLIEQIQSGKEPEVRQFFFLLSICHTVMVDRIDGQINYQAASPDEGALVNAARNFG
                     FAFLARTQNTITVSELGTERTYSVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADTV
                     IYERLHRMNPMKQETQDALDIFASETLRTLCLCYKEIEEKEFAEWNKKFMAASVASSN
                     RDEALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAE
                     NIGFACELLTEDTTICYGEDINSLLHTRMENQRNRGGVSAKFAPPAYEPFFPPGENRA
                     LIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDL
                     ACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQE
                     GMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFN
                     GYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNY
                     KKFFVSLLHGVLTSMVLFFIPFGAYLQTVGQDGEAPSDYQSFAVTMASALVITVNFQI
                     GLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASNALRQPYIW
                     LTIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWKRRQSVFRRGASS
                     RRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIIADGTAEYRRTVES"
     misc_feature    216..371
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    495..3368
                     /gene="Atp8b1"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; Region: P-type_ATPase_APLT_Dnf-like;
                     cd02073"
                     /db_xref="CDD:319770"
     misc_feature    495..3368
                     /gene="Atp8b1"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; Region: P-type_ATPase_APLT_Dnf-like;
                     cd02073"
                     /db_xref="CDD:319770"
     misc_feature    579..641
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    648..710
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    1233..1295
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    1317..1319
                     /gene="Atp8b1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4AA47.2); glycosylation site"
     misc_feature    1347..1349
                     /gene="Atp8b1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4AA47.2); glycosylation site"
     misc_feature    1371..1433
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    order(1575..1583,2001..2003,2070..2078,2268..2270,
                     2409..2417,2814..2816,2823..2825,2832..2834,2892..2894,
                     2901..2903)
                     /gene="Atp8b1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319770"
     misc_feature    order(1575..1583,2001..2003,2070..2078,2268..2270,
                     2409..2417,2814..2816,2823..2825,2832..2834,2892..2894,
                     2901..2903)
                     /gene="Atp8b1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319770"
     misc_feature    3072..3134
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    3162..3224
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    3312..3374
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    3429..3491
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    3498..3560
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     misc_feature    3642..3704
                     /gene="Atp8b1"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AA47.2);
                     transmembrane region"
     exon            397..494
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..608
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..707
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..769
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..842
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..913
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..996
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1155
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1244
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1435
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1644
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1688
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1845
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2034
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2147
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2312
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2424
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2500
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2633
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2922
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3146
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3230
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3476
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3615
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3746
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..6217
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagccgga ggagtcgcgg ccaactggac aggcttcccg gggcccccgg ccagcccccg
       61 tgtgccatgc agcgctagcg cagccgcagc gccgaggccg ggcgggaggt ggccaggtgc
      121 gcaccagcct cggaagagcc tcggagcgcc gcgcaccccg cggatgccca aacccgggcc
      181 cagagagcac caggtagttc caatttgcca gcagaatgaa cacagaaagg gactcggaaa
      241 caacatttga tgaggattcc cagcccaatg atgaagtggt tccctacagt gatgatgaaa
      301 ccgaagacga acttgaagac caggggcctg cagttgaacc agaacagaat cgtgtcaaca
      361 gagaagtcga gaaaaagaaa gagacattcc ggaaagattg cacgtggcaa gtcaaagcaa
      421 atgatcgaaa gttccacgaa caacctcatt ttatgaacac caagttcttt tgtattaagg
      481 agagcaaata tgcgagtaat gcaattaaaa catacaagta caatgcactg acctttctac
      541 ccatgaattt gtttgagcaa tttaagaggg cagccaactt ctatttcctg atcctcctga
      601 tcttgcaggc aattcctcaa atctccaccc tggcatggta taccacactt gtacctctac
      661 ttctggtgct gggcatcacg gcaatcaaag acctggtaga tgatgtggct cgccataaaa
      721 tggacaagga aatcaacaac aggacatgtg aagtcattaa ggacggcagg ttcaaaatca
      781 tcaagtggaa agatatccag gttggagacg tcatccgtct gaagaagaat gattttattc
      841 cagccgacat tctgctattg tccagctccg agcctaacag cctctgctat gtagaaacgg
      901 ctgagcttga cggagaaacc aatttgaagt tcaaaatggc cctggaaatc acagaccagt
      961 atctccaaat agaagataac ttggcgacgt ttgatggttt catcgaatgt gaggaaccaa
     1021 acaaccggtt agacaagttc acgggaacgc tcttttggag gaaccaaagt tttcctttgg
     1081 atgctgataa aatcctgttg cggggctgcg tgattaggaa caccgatgtc tgccatggct
     1141 tggtcatttt tgcaggtgct gacacgaaga taatgaagaa cagtgggaaa accagattta
     1201 aaagaactaa aatcgattac ttgatgaact acatggtgta cacgatcatt attgtcctca
     1261 tcctggtttc cgctggcctt gccattggtc acgcgtattg ggaagcacaa attggcaatt
     1321 attcctggta cctctatgat ggagaaaatg ccacaccatc ctaccggggc ttcctgaatt
     1381 tctggggcta catcattgta ttgaacacca tggtgcccat ctctctctat gtcagtgtgg
     1441 aagtgatccg tctgggacag agtcatttca tcaactggga cctgcagatg tactacgctg
     1501 agaaggacac tcctgccaag tcgaggacta ccacactgaa tgagcagcta gggcagatcc
     1561 attacatttt ctctgacaag acggggactc tcacccaaaa catcatgacc ttcaagaagt
     1621 gctgcatcaa cgggaccatc tatggagacc atcgagatgc ttctcagcac agccacagca
     1681 aaatagagct agtggacttt agctggaatg aatttgctga tgggaagctt gcattttatg
     1741 accattatct tattgagcaa atccagtcag gaaaagagcc agaagtacga cagttcttct
     1801 ttttgctttc catttgccat acggtcatgg tggacagaat tgatggtcag atcaactacc
     1861 aggcggcctc tcctgacgaa ggcgccctgg tgaacgccgc caggaacttc ggctttgcct
     1921 ttcttgccag gacgcagaac accatcaccg tcagcgaact gggcacagaa aggacctaca
     1981 gtgtgcttgc cattttggac ttcaacagcg accgaaagcg gatgtctatc atcgtgagga
     2041 ccccagaagg tagcatcagg ctatactgta aaggtgctga cacggtgatt tatgaacgac
     2101 tccatcggat gaatcccatg aagcaggaaa cacaggatgc cctggatatc tttgcaagtg
     2161 agactctcag aaccctgtgc ctgtgctaca aggaaattga agaaaaagag tttgcagagt
     2221 ggaataagaa gttcatggct gccagtgtgg cctcaagcaa ccgagacgaa gcgttggata
     2281 aagtgtacga ggagatcgag agggacttga ttctcctggg agccactgct attgaagaca
     2341 agctacagga tggagttcca gaaaccattt caaaacttgc aaaggctgac attaagatct
     2401 gggtacttac cggagacaag aaggaaactg cagaaaacat aggctttgcc tgtgaacttc
     2461 tgacagaaga cactactatc tgctatgggg aggacataaa ctctcttctt cacaccagga
     2521 tggagaatca gagaaacaga ggcggagtct ctgcgaaatt tgcacccccc gcgtatgaac
     2581 ccttttttcc acctggagaa aaccgtgcct taatcatcac tggctcgtgg ttgaatgaga
     2641 tccttctaga gaagaagacc aagagaagta agatcctgaa gctgaagttc ccaaggaccg
     2701 aggaggagag gcggatgcgg agccagagtc ggaggcggct ggaagagaag aaagagcagc
     2761 ggcagaagaa ttttgtggac ctggcctgtg agtgcagcgc tgtcatctgc tgccgcgtca
     2821 cacccaagca gaaggccatg gtggtggacc tggtgaagag gtacaagaag gccatcacgc
     2881 tggccatcgg agacggggcc aacgatgtga acatgatcaa aactgcccac attggagttg
     2941 gaataagcgg acaagaaggc atgcaagctg tcatgtccag tgactattct tttgctcagt
     3001 tcagatacct gcagcgcttg ctgctggtcc atggccggtg gtcttacata aggatgtgca
     3061 agttcctacg ctatttcttt tacaagaact ttgcatttac tttggttcat ttctggtact
     3121 ccttcttcaa tggctactca gcccagacgg cgtatgagga ctggtttatc accctgtaca
     3181 atgtgctgta ctccagtttg cctgtgctcc tcatggggct gctcgatcag gatgtgagcg
     3241 acaagctgag cctccgattc cctgggttgt atgtagtggg acagagagac ttgctgttca
     3301 actataagaa gttctttgtc agtttgctgc acggggtctt aacctcaatg gtcctcttct
     3361 tcataccgtt tggcgcttac ctgcaaacag tgggacagga tggagaggca ccttcagact
     3421 accagtcctt tgccgtcaca atggcctcgg ctctagtgat aacggtcaat ttccagatcg
     3481 gcttggatac gtcgtactgg acgttcgtga atgccttttc catttttgga agcatcgcgc
     3541 tgtactttgg catcatgttt gatttccata gtgctgggat ccatgttctc ttcccatctg
     3601 cattccagtt cacaggtacg gcttccaatg ccctgagaca gccgtatatt tggctgacga
     3661 tcatcctgac ggttgcagtt tgcttgttac ctgtcgtcgc catccgtttc ctgtcaatga
     3721 ccatctggcc atcagaaagt gataagatcc agaagcatcg aaagcgattg aaggccgaag
     3781 agcagtggaa acggcggcag agcgtgttcc ggaggggagc atcttcccgg cgctccgcct
     3841 acgccttctc gcaccagagg ggctatgcgg acctcatctc ctctggccgc agcatccgca
     3901 agaagcgctc gcccctggac gccatcatcg cagatggcac agcggagtac cgacgcacag
     3961 tggagagctg aggggcactg ctctgctgag agaccggagc tctgggaaaa tgtctttttt
     4021 ttttttttct ttaatgaaca actcaggact ttttaaaaaa aaaaaataaa ctgaggttgt
     4081 cacagtgaca ctgatgacaa taaccttttc aataaacttc taggattgtg ctcttaagca
     4141 gtagcaaagc caagagacca cctgttattc agctgactgc ctcgctgaga ttcaaaggga
     4201 acgcttcttt tttttaaatc caggcctaat ggaagacggc agaatttaga aaagtctcct
     4261 tttcagcttg aaggatacta ctacactaca aagttacaat cacactctcc tatctctggc
     4321 ctcaagcatg gatttctcag acgcactcct ccctctgctt gtcactttta aaaaaaggaa
     4381 gaaagaaaat ctgtttttta atttatgagt gcagtaacaa cgggttccta atgtttacca
     4441 cctgatgtga ggtggtttaa tgactttttc aggcccggtg atcaggttcc ctggttcttt
     4501 ctaccaattt tcgaaattcg aaacaagttt ccttgattga atgatcaagg gcaacatttc
     4561 atgctggttt tgatttacta cgaggttaaa taatggattc catgttttta ctagttggta
     4621 ttttcctggg ctaccaagtg gtttgactcc ctacttcaat tttttccaaa aatgattttc
     4681 aaaagctgag gacgttatca actagtatta agttccattt agataagagt gcatttgttg
     4741 cacagtaaag gactgtagat gatgagaatg gaatgtgtgt ttcagaaatg ctagacgaaa
     4801 gggatttgag tgttttcaac acaaagtgat acctgaagag atggacaaac cgtgatgtca
     4861 acattacaca atgtacacat gtggaggaac accccatgtc gggctacctt gtggcttggt
     4921 ggtagagttg ggggtcttag gtcccatatt ggtacaaaaa aaaaaaagaa acatcacgtg
     4981 gtgttccata aatatgcaca attgtgggtc acttaagatt gactagaaaa ggacaggaca
     5041 acgcctactg aaagtttgct tgtggtttcc tttggaagac aaactagtta gcccttccta
     5101 actggatggg ctctgggggg cagggacaag agtgttgatg ggaacattgt tactattacc
     5161 cacaacagag gagaatgaaa catagaaagg tgtattcaaa ctgctgcctg tggccacatt
     5221 tagccaagga gaactatgaa tgtagtccaa taccaaaatg gtaaaagtta cttttactta
     5281 aaacactatg agattgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     5341 tgtgtgttgt gtatgtgcac ttatgattcc actgtttggt tcttgagttg agctttgtag
     5401 gttgtttgcc ccagtgtcag gagcttggac ctacctggta gggggagtct gttgagaaat
     5461 ttcccttgtg tttctgagaa gcaaaaaaga ggttcagtat agataagttt aagcaaacaa
     5521 actaaaaagc ccagagggca ttagtgatac atttgggaat attttgcaga gttgtctgtt
     5581 gaaaagaaac tgtgtccccc ttcctagaaa atattctata agagtctttc agagcctcgc
     5641 tctagcttac gtctgagaca aaagaacagt atttttttta ttttgaaaaa acattaggtg
     5701 gttaaggaaa atatccttga aaaggtaact tatcccctcc cccattttat ttccttcacg
     5761 aaacagtctc cctattctac agaaggtgcc cacaggttac ttttctcctt tgcaaatgtt
     5821 catagcagtc tgtgaattcc aaagaggaaa ccatatgtag tttgtcttct atacacagga
     5881 caggaaaaat taaatcgtac ttttagaatg cattgaaaga atgtacttct atctcctgga
     5941 ggtaaatttc tgaaagttta caactttact atgtatataa aaagaattgt acgtttttcc
     6001 cttttttttt tacagaaaat ttagcttgtg aaattttgtc aggtttcgct ttcattgttt
     6061 ttgaatggcg ggaagggttg acaatgcaaa tgtgtcaaag acttactggg tgcaatatta
     6121 ataatttaaa atgcaaatca taaattattt ctatatgctg taaatctgag atttaatgta
     6181 tatttttgtt taaaaaaata aatgctttag taaaata
//
LOCUS       NM_001437544             903 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus TPD52 like 3 (Tpd52l3), transcript variant 2,
            mRNA.
ACCESSION   NM_001437544 XM_006231260
VERSION     NM_001437544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 903)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006231260.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.860937.1, CR463267.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-782               JAXUCZ010000001.1  237195683-237196464
            783-903             JAXUCZ010000001.1  237197868-237197988
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..903
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="TPD52 like 3"
                     /db_xref="GeneID:293894"
                     /db_xref="RGD:1309391"
     exon            1..782
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..822
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="isoform 2 is encoded by transcript variant 2; tumor
                     protein D55; tumor protein D55-like; tumor protein
                     D52-like 3"
                     /codon_start=1
                     /product="tumor protein D55 isoform 2"
                     /protein_id="NP_001424473.1"
                     /db_xref="GeneID:293894"
                     /db_xref="RGD:1309391"
                     /translation="MDPSHLESHPSGQKSEPAGLDVSSTSPNCFSSNQGLDSVYQELD
                     LDSLNEDLSLSVSDAMTETSASTNEFHLASEPDLTEAEQMELRSELTKLEEEILSLRD
                     LLAAKEKRCGELKRKLGCVALVGLRQNLSKSWHDVQASNTYMKQKTSTALASMGSAIC
                     RKLGDMKKSSTFKSLEELVGTVKSRVAGGRELGSGLLPSPASGSDPHSVLGSGYETVS
                     GLDDQLFSLLKPDETKYCCQYRRSR"
     misc_feature    322..618
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="Tumour protein D52 family; Region: TPD52;
                     pfam04201"
                     /db_xref="CDD:461225"
     misc_feature    322..618
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /note="Tumour protein D52 family; Region: TPD52;
                     pfam04201"
                     /db_xref="CDD:461225"
     exon            783..903
                     /gene="Tpd52l3"
                     /gene_synonym="RGD1309391; Trpd52l3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacccggaag tggatcccca tcaaaagcgt cccatcctct cgacaggacg tagacttatc
       61 aaccagtgcc tgacttttgc tgcccaagat atggacccgt ctcacctcga gtcccatccc
      121 tctggccaga agtctgagcc tgcaggccta gacgttagct ccaccagccc taactgtttc
      181 tcctcaaacc aaggactgga ttctgtctat caagaactgg acctggactc cctgaacgaa
      241 gatctttctt tgtctgtttc agatgccatg acagagacct ctgcatccac aaatgaattc
      301 cacctagctt cagaaccaga tctgacggag gctgagcaaa tggagctcag atctgagctt
      361 actaaattgg aggaagagat cttaagcttg cgtgacctgc tcgcagccaa agagaagcgg
      421 tgtggcgaac tcaagaggaa gttaggctgc gtggccttgg tgggactgag gcagaatctg
      481 tccaagagct ggcatgatgt tcaggcctcc aacacctaca tgaagcagaa gacttcaact
      541 gccctggcct cgatgggttc tgccatctgc aggaagcttg gagacatgaa gaagtcgtcc
      601 acgttcaaat ctcttgaaga gctggtgggg acagtcaagt caagagtcgc gggtggcaga
      661 gagctcggca gtggccttct tccttcacca gcgagtggca gcgatccaca ctcggttctg
      721 gggagtggat atgaaactgt ttcagggctt gatgatcaac tgttttctct cctgaagcca
      781 gatgaaacta aatactgctg tcaatataga agatctcggt aaactgtaaa gccattgaaa
      841 aatcccagcc ctcgactgag tcccaaaggc catgtcttgc ttggattaaa acaaattata
      901 caa
//
LOCUS       NM_134371               4165 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 8 (Trpm8), mRNA.
ACCESSION   NM_134371
VERSION     NM_134371.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Kozyreva,T.V., Orlov,I.V., Boyarskaya,A.R. and Voronova,I.P.
  TITLE     Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of
            temperature homeostasis at water balance changes
  JOURNAL   Neurosci Lett 828, 137763 (2024)
   PUBMED   38574849
  REMARK    GeneRIF: Hypothalamic TRPM8 and TRPA1 ion channel genes in the
            regulation of temperature homeostasis at water balance changes.
REFERENCE   2  (bases 1 to 4165)
  AUTHORS   Skagen,C., Lovsletten,N.G., Asoawe,L., Al-Karbawi,Z., Rustan,A.C.,
            Thoresen,G.H. and Haugen,F.
  TITLE     Functional expression of the thermally activated transient receptor
            potential channels TRPA1 and TRPM8 in human myotubes
  JOURNAL   J Therm Biol 116, 103623 (2023)
   PUBMED   37542841
  REMARK    GeneRIF: Functional expression of the thermally activated transient
            receptor potential channels TRPA1 and TRPM8 in human myotubes.
REFERENCE   3  (bases 1 to 4165)
  AUTHORS   Chakraborty,R. and Goswami,C.
  TITLE     Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels
            regulate microglial activity
  JOURNAL   Biochem Biophys Res Commun 611, 132-139 (2022)
   PUBMED   35489198
  REMARK    GeneRIF: Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion
            channels regulate microglial activity.
REFERENCE   4  (bases 1 to 4165)
  AUTHORS   Huang,Y., Li,S., Jia,Z., Li,S., He,W., Zhou,C., Zhang,R., Xu,R.,
            Sun,B., Ali,D.W., Michalak,M., Chen,X.Z. and Tang,J.
  TITLE     TRIM4 interacts with TRPM8 and regulates its channel function
            through K423-mediated ubiquitination
  JOURNAL   J Cell Physiol 236 (4), 2934-2949 (2021)
   PUBMED   33037615
  REMARK    GeneRIF: TRIM4 interacts with TRPM8 and regulates its channel
            function through K423-mediated ubiquitination.
REFERENCE   5  (bases 1 to 4165)
  AUTHORS   Lai,H., Liu,C., Hou,L., Lin,W., Chen,T. and Hong,A.
  TITLE     TRPM8-regulated calcium mobilization plays a critical role in
            synergistic chemosensitization of Borneol on Doxorubicin
  JOURNAL   Theranostics 10 (22), 10154-10170 (2020)
   PUBMED   32929340
  REMARK    GeneRIF: TRPM8-regulated calcium mobilization plays a critical role
            in synergistic chemosensitization of Borneol on Doxorubicin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4165)
  AUTHORS   Hu,H.Z., Gu,Q., Wang,C., Colton,C.K., Tang,J., Kinoshita-Kawada,M.,
            Lee,L.Y., Wood,J.D. and Zhu,M.X.
  TITLE     2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2,
            and TRPV3
  JOURNAL   J Biol Chem 279 (34), 35741-35748 (2004)
   PUBMED   15194687
REFERENCE   7  (bases 1 to 4165)
  AUTHORS   Nealen,M.L., Gold,M.S., Thut,P.D. and Caterina,M.J.
  TITLE     TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal
            neurons from rat
  JOURNAL   J Neurophysiol 90 (1), 515-520 (2003)
   PUBMED   12634279
  REMARK    GeneRIF: TRPM8 is preferentially expressed within a subset of
            rapidly responsive, low-threshold (approximately 30 degrees C),
            cold-sensitive neurons in trigeminal ganglia.
REFERENCE   8  (bases 1 to 4165)
  AUTHORS   Story,G.M., Peier,A.M., Reeve,A.J., Eid,S.R., Mosbacher,J.,
            Hricik,T.R., Earley,T.J., Hergarden,A.C., Andersson,D.A.,
            Hwang,S.W., McIntyre,P., Jegla,T., Bevan,S. and Patapoutian,A.
  TITLE     ANKTM1, a TRP-like channel expressed in nociceptive neurons, is
            activated by cold temperatures
  JOURNAL   Cell 112 (6), 819-829 (2003)
   PUBMED   12654248
REFERENCE   9  (bases 1 to 4165)
  AUTHORS   Peier,A.M., Moqrich,A., Hergarden,A.C., Reeve,A.J., Andersson,D.A.,
            Story,G.M., Earley,T.J., Dragoni,I., McIntyre,P., Bevan,S. and
            Patapoutian,A.
  TITLE     A TRP channel that senses cold stimuli and menthol
  JOURNAL   Cell 108 (5), 705-715 (2002)
   PUBMED   11893340
REFERENCE   10 (bases 1 to 4165)
  AUTHORS   McKemy,D.D., Neuhausser,W.M. and Julius,D.
  TITLE     Identification of a cold receptor reveals a general role for TRP
            channels in thermosensation
  JOURNAL   Nature 416 (6876), 52-58 (2002)
   PUBMED   11882888
  REMARK    GeneRIF: CMR1 is a member of the TRP family of excitatory ion
            channels and is proposed to function as a transducer of cold
            stimuli in the somatosensory system
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134371.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY072788.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000009.1  96351683-96351715
            34-155              JAXUCZ010000009.1  96364479-96364600
            156-229             JAXUCZ010000009.1  96368424-96368497
            230-386             JAXUCZ010000009.1  96372666-96372822
            387-564             JAXUCZ010000009.1  96373628-96373805
            565-737             JAXUCZ010000009.1  96375632-96375804
            738-912             JAXUCZ010000009.1  96378783-96378957
            913-980             JAXUCZ010000009.1  96380090-96380157
            981-1178            JAXUCZ010000009.1  96384661-96384858
            1179-1281           JAXUCZ010000009.1  96388803-96388905
            1282-1400           JAXUCZ010000009.1  96390578-96390696
            1401-1691           JAXUCZ010000009.1  96395599-96395889
            1692-1787           JAXUCZ010000009.1  96397596-96397691
            1788-1917           JAXUCZ010000009.1  96398589-96398718
            1918-2063           JAXUCZ010000009.1  96399081-96399226
            2064-2176           JAXUCZ010000009.1  96402172-96402284
            2177-2393           JAXUCZ010000009.1  96402899-96403115
            2394-2485           JAXUCZ010000009.1  96407199-96407290
            2486-2627           JAXUCZ010000009.1  96408083-96408224
            2628-2799           JAXUCZ010000009.1  96409265-96409436
            2800-2977           JAXUCZ010000009.1  96411502-96411679
            2978-3168           JAXUCZ010000009.1  96421698-96421888
            3169-3268           JAXUCZ010000009.1  96426453-96426552
            3269-3302           JAXUCZ010000009.1  96427970-96428003
            3303-3394           JAXUCZ010000009.1  96431874-96431965
            3395-4165           JAXUCZ010000009.1  96435575-96436345
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..4165
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 8"
                     /db_xref="GeneID:171384"
                     /db_xref="RGD:620762"
     exon            1..33
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..155
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..3353
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="cold menthol receptor 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 8"
                     /protein_id="NP_599198.2"
                     /db_xref="GeneID:171384"
                     /db_xref="RGD:620762"
                     /translation="MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNF
                     IQANFKKRECVFFTRDSKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDA
                     FGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPR
                     MRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWG
                     MVSNRDTLIRNCDDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAK
                     LRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQ
                     IADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESPHLLT
                     VIKMEEAGDEVVSSAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTND
                     RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRN
                     LQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFI
                     WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETR
                     AVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQW
                     YGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSW
                     NVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLW
                     NVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPK
                     IIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ
                     VPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLVCIYMLSTNILLV
                     NLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFK
                     CCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRHRFRQLDTK
                     LNDLKGLLKEIANKIK"
     misc_feature    384..1115
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; cl39032"
                     /db_xref="CDD:476852"
     misc_feature    384..1115
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="SLOG in TRPM; Region: LSDAT_euk; cl39032"
                     /db_xref="CDD:476852"
     misc_feature    <2007..3053
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    <2007..3053
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); Region: TRPV; cl40437"
                     /db_xref="CDD:454755"
     misc_feature    2238..2312
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     misc_feature    2334..2405
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     misc_feature    2427..2489
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     misc_feature    2505..2582
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     misc_feature    2598..2708
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     misc_feature    2898..2990
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R455.4);
                     transmembrane region"
     exon            156..229
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..386
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..564
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..737
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..912
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..980
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1178
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1281
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1400
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1691
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1787
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1917
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2063
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2176
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2393
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2485
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2627
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2799
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2977
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3168
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3268
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3302
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3394
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..4165
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaagctc ttggctgttt gagcagctcc acggcaagat gtccttcgag ggagccaggc
       61 tcagcatgag gagccgcaga aatggaactc tgggcagcac ccggaccctg tactccagcg
      121 tgtctcggag cacagacgtg tcctacagtg aaagtgattt ggtgaatttt attcaggcaa
      181 attttaaaaa acgagaatgc gtcttcttta ccagagactc caaggccatg gagagcatat
      241 gcaagtgtgg ttatgcccag agccagcata tcgaaggcac ccagatcaac caaaatgaga
      301 agtggaacta caaaaaacac accaaggagt ttccaacaga cgcctttggg gacattcagt
      361 ttgagactct ggggaagaaa ggcaagtact tacgcttatc ctgtgacacg gactctgaaa
      421 ccctctacga actgctgacc cagcactggc acctcaaaac acccaacctg gtcatctcag
      481 tgacgggtgg agccaaaaac tttgctttga agccacgcat gcgcaaaatc ttcagtcggc
      541 tgatctacat cgctcagtct aaaggggcat ggattcttac cggaggcact cattacgggc
      601 tgatgaagta cataggtgag gtggtgagag ataacaccat cagcaggaac tcggaagaga
      661 acatcgtggc catcggcata gcggcctggg gcatggtctc caacagggac accctcatca
      721 ggaattgtga tgatgaggga catttttcag ctcaatatat catggatgac ttcatgagag
      781 atcctctcta catcctggac aacaatcata cccacctgct gcttgtggac aacggttgtc
      841 atggacaccc cacggtggaa gccaaacttc ggaatcagct ggagaagtac atctctgagc
      901 gcaccagtca agattccaac tatggtggta agatccccat cgtgtgtttt gcccagggag
      961 gtggaagaga aactttgaaa gccatcaaca cctctgtcaa aagtaagatc ccctgtgtgg
     1021 tggtggaagg ctcggggcag attgccgatg tgattgccag cctggtggag gtagaggatg
     1081 ttttaacctc ttccatggtc aaagagaagc tggtacggtt tttaccccgc actgtgtccc
     1141 ggctgcctga agaggagatt gagagctgga tcaaatggct caaagaaatt cttgagagcc
     1201 cccacctcct cacggtcatc aagatggagg aggctggaga cgaggtcgtg agcagcgcca
     1261 tttcctacgc gctgtacaaa gccttcagca ctaatgaaca agacaaggac aactggaacg
     1321 gacagctgaa gcttctgctg gagtggaacc aactggacct tgccagtgat gagatcttca
     1381 ccaatgaccg ccgctgggag tctgccgacc ttcaggaagt catgttcacg gccctcataa
     1441 aggacaggcc caagtttgtc cgcctcttcc tggagaatgg cctcaacctg cagaagttcc
     1501 tcaccaatga agtcctcacg gagctcttct ccacccactt cagcacccta gtgtaccgga
     1561 acctgcagat cgccaagaac tcctacaacg atgcactcct tacctttgtc tggaagttgg
     1621 tggcaaactt ccgtagaagc ttctggaaag aggacagaag cagcagggag gacttggatg
     1681 tggaactcca tgatgcatct ctcaccaccc ggcaccccct gcaggctctt ttcatctggg
     1741 ccattcttca gaacaagaag gaactctcca aggtcatctg ggagcagacc aaaggctgta
     1801 ctctggccgc cttgggggcc agcaaacttc tgaagaccct ggccaaagtt aagaatgata
     1861 tcaacgcagc tggggaatct gaggaactgg ctaatgagta tgagacccga gcagtggagt
     1921 tgttcactga gtgttacagc agtgatgagg acttggcaga acagctactg gtctactctt
     1981 gtgaagcctg gggtgggagc aactgtctgg agctggcggt ggaggctacg gaccagcatt
     2041 tcattgctca gcctggggtc cagaatttcc tttctaagca atggtatgga gagatttccc
     2101 gagacacgaa gaactggaag attatcctgt gtctgttcat catccccctg gtgggctgtg
     2161 gcctcgtatc gtttaggaag aagcccattg acaagcacaa gaagctgctc tggtactacg
     2221 tggccttctt cacttcgccc ttcgtggtct tctcctggaa cgtggtcttc tacatcgcct
     2281 tcctcctgct gtttgcgtat gtgctgctca tggacttcca ctcggtgcca cacacccccg
     2341 agctgatcct ctatgccctg gtcttcgtcc tcttctgtga tgaagtgagg cagtggtaca
     2401 tgaacggagt gaattatttc accgacctat ggaacgttat ggacacactg ggacttttct
     2461 acttcatagc gggtattgta ttccggcttc actcttcaaa taaaagctct ttgtactccg
     2521 ggcgagtcat tttctgtctg gattacatta tattcactct aaggctcatc cacattttca
     2581 ccgtgagcag gaacctggga cccaagatta taatgctgca gcggatgctc atcgacgttt
     2641 tcttcttctt gtttctcttt gctgtgtgga tggtggcctt cggcgtagcc agacagggga
     2701 tccttaggca aaatgaacag cgctggaggt ggatcttccg ctctgtcatc tatgagccct
     2761 acctggccat gtttggccag gtgcccagtg atgtggacag taccacatat gacttctccc
     2821 actgcacctt ctcgggaaat gagtccaagc cactgtgcgt ggagctagat gaatacaatc
     2881 tgccccgctt ccctgagtgg atcaccatcc cactagtgtg catctacatg ctctccacca
     2941 acatccttct ggtcaatctc ctggtcgcca tgtttggcta cacggtgggc attgtgcagg
     3001 agaacaacga tcaggtctgg aagttccagc ggtacttcct ggtgcaggag tactgcaacc
     3061 gcctcaacat ccccttcccc ttcgtcgtct tcgcttactt ctacatggtg gtcaagaagt
     3121 gtttcaaatg ctgctgtaaa gagaagaaca cggagtcttc tgcctgctgt ttcagaaatg
     3181 aggacaacga gactttggcg tgggagggcg tcatgaagga gaattacctt gtcaagatca
     3241 acacgaaggc caacgacaac gcagaggaga tgaggcatcg gttcagacaa ctggacacaa
     3301 agcttaatga tctcaaaggt cttctgaaag agattgctaa taaaatcaaa taaggcaggc
     3361 gactgctcat ggagagaagt caaattgcaa taagatcaaa tcaaacacct ggatttggag
     3421 gctcgtggga ctctgataaa caatactgct attgacttct aaaggagaca tttccaggtc
     3481 cctgggcaca aagtggatga gtcatagtca ccctcaaggg cataggtcag ggaccaaagt
     3541 gtacagagaa ctgtgcacaa gaagaggagt gcaaaggttc ctccatgaag gtgcctgtgc
     3601 tgtctgcatc tcggagcctt gaactgatgc tgaaggttta agtgatgaca cacctttccc
     3661 accctcgtct catgcacctc ccatgactgt gaccctggcc ctgattttac acctacactg
     3721 ctattgtgtt tatttcctac tgtccccttt ctgcattgta tgatgaattc atcgacatag
     3781 tgtcagagtc ctacaccacc ccaaagaaaa gtcaggccgg atgctaaaat accctggggc
     3841 aacctctcct ttctcacatg tcaaacgtgg gaggtgtggg gggggcacac ggaggcagtg
     3901 acttctttct ctggggctct ccaggactcc tgctgaagga acccttgaga gccgtacctt
     3961 gctccttttg attttgggag tgtgcctctc ctccattctc tcattatttc cccattgaga
     4021 atagcaaatg gatctcacag gaggttagag gagcacaaaa atgtatggaa acggcctccc
     4081 actcacagcc cttgctcaca cttccgtgtg tttgctcaat cccagccttt tctatgcatg
     4141 ctacacttca cttttaaaaa aaaaa
//
LOCUS       NM_001437515            3188 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 like 4A
            (Epb41l4a), transcript variant 2, mRNA.
ACCESSION   NM_001437515 XM_006254584
VERSION     NM_001437515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254584.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.62221.1,
                                           SRR26643297.49650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000018.1  25888993-25889375   c
            384-821             JAXUCZ010000018.1  25888201-25888638   c
            822-926             JAXUCZ010000018.1  25802641-25802745   c
            927-978             JAXUCZ010000018.1  25773271-25773322   c
            979-1057            JAXUCZ010000018.1  25768091-25768169   c
            1058-1155           JAXUCZ010000018.1  25762381-25762478   c
            1156-1276           JAXUCZ010000018.1  25761136-25761256   c
            1277-1364           JAXUCZ010000018.1  25759154-25759241   c
            1365-1453           JAXUCZ010000018.1  25756917-25757005   c
            1454-1517           JAXUCZ010000018.1  25756320-25756383   c
            1518-1609           JAXUCZ010000018.1  25743152-25743243   c
            1610-1687           JAXUCZ010000018.1  25741649-25741726   c
            1688-1809           JAXUCZ010000018.1  25736039-25736160   c
            1810-1900           JAXUCZ010000018.1  25715494-25715584   c
            1901-1984           JAXUCZ010000018.1  25711524-25711607   c
            1985-2098           JAXUCZ010000018.1  25710913-25711026   c
            2099-2146           JAXUCZ010000018.1  25708322-25708369   c
            2147-2224           JAXUCZ010000018.1  25707400-25707477   c
            2225-2344           JAXUCZ010000018.1  25694243-25694362   c
            2345-2392           JAXUCZ010000018.1  25686822-25686869   c
            2393-2461           JAXUCZ010000018.1  25685951-25686019   c
            2462-2572           JAXUCZ010000018.1  25681986-25682096   c
            2573-2654           JAXUCZ010000018.1  25681789-25681870   c
            2655-3188           JAXUCZ010000018.1  25680164-25680697   c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3188
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="erythrocyte membrane protein band 4.1 like 4A"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
     exon            1..383
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            384..821
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    699..701
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="upstream in-frame stop codon"
     CDS             723..2789
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="isoform 1 is encoded by transcript variant 2;
                     erythrocyte protein band 4.1-like 4a; band 4.1-like
                     protein 4A"
                     /codon_start=1
                     /product="band 4.1-like protein 4A isoform 1"
                     /protein_id="NP_001424444.1"
                     /db_xref="GeneID:307514"
                     /db_xref="RGD:1306034"
                     /translation="MGCFCAVPEEFYCEVLLLDESKLTLTTQHQGIKKSTKGSVVLDH
                     VFRHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAED
                     PCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQLGAYAIQAELGDHDPCKHTAGYV
                     SEYRFVPDQKEELEESIERIHKTLMGQAPSEAELNYLRTAKSLEMYGVDLHPVYGENK
                     SEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEAR
                     SKTACKHLWKCSVEHHTFFRMPETESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLS
                     IQLPRPNQNVVRSRSKTYPKRVAQTQPAGSNSINRMTANLENGENEGTTKIIAPSPVK
                     SFKKAKNENSPDPQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPCTRQRNLSCGSDN
                     DSSQPMRRRKAHHSGEDSDLKQRRRSRSRCNTSSGSESENSNREHRKKRNRIRQENDM
                     VDSAPQWEAVLRRQKEKNQVDPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGL
                     SEEQLKEIPYTKVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVP
                     PLPVTRSSDAQGSGGSTVHQRRNGSKDSLIEEKSQLSTTNLAGKHTAKTIKTIQAARL
                     KTDVTG"
     misc_feature    759..1355
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    759..1355
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    1341..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    1341..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM domain C-lobe of Novel band 4.1-like protein 4
                     and 5 (NBL4 and 5); Region: FERM_C_NBL4_NBL5; cd13186"
                     /db_xref="CDD:270007"
     misc_feature    order(1365..1367,1416..1418,1422..1424,1440..1442)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1365..1367,1416..1418,1422..1424,1440..1442)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1452..1454,1467..1478,1575..1577,1587..1589,
                     1596..1601)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    order(1452..1454,1467..1478,1575..1577,1587..1589,
                     1596..1601)
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1575..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1575..1610
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270007"
     misc_feature    1653..1787
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     misc_feature    1653..1787
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /note="FERM adjacent (FA); Region: FA; pfam08736"
                     /db_xref="CDD:462582"
     exon            822..926
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            927..978
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1057
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1155
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1276
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1364
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1453
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1517
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1609
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1687
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1809
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1900
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1984
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2098
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2146
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2224
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2344
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2392
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2461
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2572
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2654
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..3188
                     /gene="Epb41l4a"
                     /gene_synonym="Epb4.1l4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacctgca ggcacccagc cagactgacc acctccgccc cgccctccgc ccccggctga
       61 gaccccgccc tgaagggggg cgctcgggtc accgtcccgg ggctatccag cttcagatcc
      121 gaggcttttt gccgacaccc cgggccggga cccgctgtac ctgggctgct ccctccaggg
      181 ccccgccctg cgcgccacca agaactttcc ctggagcctc ggaggcctgg cgccccgggt
      241 tctgccgcgc cgcccgcagg tcctcagaca cccggctttt ccaggacgtt cggggaagga
      301 agcttgaact tggccatctc cgcgggatga gttcggggac cttcggacag aagctacagg
      361 ccgcgacaag ctgacctccc ccggtcgccg ccccattctt cagaagagga gctgctgccg
      421 caggatgcgc ggggacgcgc cacccctggt tcccagttct gcggacgctt ctcgggcgac
      481 tccgggctct tgacgccccg aggcgcgctc gccctcccgc cttcgctgtc cgagcctctc
      541 ggggtgcctt cggctcacca tagaacccca gaccttaccc tcacccgggg ggccccaccc
      601 agacccgcgc ctctcgccct ctacacggcg cgcacaataa attaatgctt cgcgcttgag
      661 gggaggcggc ggcgggcgcc gcggtcgctg ctctcgcctg actggagacg ctttcagccg
      721 acatgggctg tttctgcgcc gttccggaag aattttactg cgaagttttg ctcctggacg
      781 agtccaagct caccctcacc acccagcacc agggcatcaa gaagtcaacc aaaggttccg
      841 ttgtccttga ccatgttttc cgtcacgtaa acctcgtgga gatagattat tttggtctgc
      901 gatactgcga cagaagccat cagacatatt ggctggatcc cgcaaaaact cttgcagaac
      961 acaaggaact aatcaacact ggacctccgt atactttgta ttttggtatt aaattctatg
     1021 ctgaagatcc atgtaagctc aaagaagaga taaccagata tcagtttttc ttacaggtga
     1081 agcaagatgc ccttcagggc cgtctgcctt gtcctgtcaa tattgccgct cagctgggag
     1141 cctatgccat ccaggccgaa ctgggagacc acgacccatg taagcacact gcggggtacg
     1201 tgtcggagta ccggtttgtt cctgatcaga aggaagaact ggaagaatct atagaaagga
     1261 ttcacaagac tctaatgggt caggctcctt ccgaagctga gctgaattac ttgaggactg
     1321 cgaaatccct ggagatgtac ggcgttgacc tccatcctgt ctatggagaa aataagtccg
     1381 agtatttctt aggattgact ccagtgggtg ttgtcgtcta taagaataaa aagcaagtgg
     1441 ggaagtattt ctggcctcgg attaccaagg tgcacttcaa ggaaacccag tttgaactca
     1501 gagtcttggg aaaagactgt aatgagacct cgttcttttt tgaagctcgg agcaaaactg
     1561 cttgcaaaca cctctggaaa tgcagtgtgg agcaccatac atttttcagg atgccagaaa
     1621 cagagtcaaa ttcactgtca agaaaactca gcaagtttgg gtccataagt tataaacacc
     1681 gatacagtgg caggacagct ttgcaaatga gccgagatct ttccatccaa cttccccggc
     1741 ccaaccagaa cgtggtgaga agtcgaagca agacttaccc caagagggta gcacagacgc
     1801 agcccgctgg atccaacagc atcaatcgga tgactgcaaa cttggaaaac ggggagaatg
     1861 aaggaaccac caagatcatt gcgccctcac cagtgaaaag ttttaagaaa gcaaagaatg
     1921 aaaacagtcc tgacccccaa agaagcaaat ctcatgcacc atgggaagaa aacggacccc
     1981 agagtggact ctacaactcc cccagtgacc gcactaagtc accaaagttt ccctgtaccc
     2041 ggcagcgcaa cctctcctgt ggcagcgaca atgactcctc gcagccaatg aggcgaagga
     2101 aggctcacca cagtggggaa gactcggatc taaagcaacg gaggaggtca cgctcacgct
     2161 gtaacacgag cagtggtagt gagtcagaaa attctaacag agaacaccgg aagaagagaa
     2221 acagaatacg acaggagaat gacatggttg attcagcgcc tcagtgggaa gccgtgttaa
     2281 ggagacagaa ggagaaaaac caagtggatc ctaacaaccg gagatccagg cacagatctc
     2341 gctcgagaag tcctgatatc caagcaaaag aagaactgtg gaagcatatc cagaaggagc
     2401 ttgtggaccc atccgggttg tcagaggagc agttgaaaga gatcccatac actaaagtgg
     2461 agactcaggg tgaccctgtc cgcatcaggc attcgcattc cccaaggagt taccggcagt
     2521 accgcagatc ccagtgctca gacggagagc gatccgtcct ctcggaagtg aactcaaaga
     2581 cagatcttgt accaccactt ccagtcaccc gttcctcaga tgctcagggg tctggaggct
     2641 ctacagttca tcagagaaga aacgggtcta aagacagcct gattgaagaa aaatctcagc
     2701 tttctacaac caacctggct ggaaaacata cagcaaaaac aataaaaacc atccaggctg
     2761 ctcggctcaa gacagacgtc actgggtgaa ggggtgtagg gaaacgtgtg tcactggtac
     2821 ttttcaaact gtgaattaga taattaccca cgtatcttgg actcgtgtcc ttagcacaag
     2881 aaaattggca tcttttaagg atttatgtac agcattcttg tgctgtgggc ctttggaagg
     2941 acaaccttat gaactcactg gataccacca tctctttcct gaaattctga ccatccaact
     3001 gtgtttctca cctctccacc acagccaaga ccagaggctt cagatgagcc cctggactcc
     3061 cagctgccat cagactgtag tgacttttat tcccacaact gtttgtaata ttgtattttg
     3121 tgacatttaa gtcccaatgg ttatttacaa ataatgtaaa aagctgttaa gtgttgattt
     3181 gaatttaa
//
LOCUS       NM_001437036            2077 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus tRNA isopentenyltransferase 1 (Trit1), mRNA.
ACCESSION   NM_001437036
VERSION     NM_001437036.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Yarham,J.W., Lamichhane,T.N., Pyle,A., Mattijssen,S., Baruffini,E.,
            Bruni,F., Donnini,C., Vassilev,A., He,L., Blakely,E.L., Griffin,H.,
            Santibanez-Koref,M., Bindoff,L.A., Ferrero,I., Chinnery,P.F.,
            McFarland,R., Maraia,R.J. and Taylor,R.W.
  TITLE     Defective i6A37 modification of mitochondrial and cytosolic tRNAs
            results from pathogenic mutations in TRIT1 and its substrate tRNA
  JOURNAL   PLoS Genet 10 (6), e1004424 (2014)
   PUBMED   24901367
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.23578.1,
                                           SRR26643298.28774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000005.1  140580453-140580639
            188-328             JAXUCZ010000005.1  140607602-140607742
            329-427             JAXUCZ010000005.1  140612376-140612474
            428-573             JAXUCZ010000005.1  140613178-140613323
            574-716             JAXUCZ010000005.1  140615711-140615853
            717-828             JAXUCZ010000005.1  140617346-140617457
            829-941             JAXUCZ010000005.1  140617799-140617911
            942-1019            JAXUCZ010000005.1  140618119-140618196
            1020-1129           JAXUCZ010000005.1  140620926-140621035
            1130-1247           JAXUCZ010000005.1  140621329-140621446
            1248-2077           JAXUCZ010000005.1  140623052-140623881
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2077
                     /gene="Trit1"
                     /note="tRNA isopentenyltransferase 1"
                     /db_xref="GeneID:362586"
                     /db_xref="RGD:1304781"
     exon            1..187
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1417
                     /gene="Trit1"
                     /EC_number="2.5.1.75"
                     /note="tRNA dimethylallyltransferase, mitochondrial"
                     /codon_start=1
                     /product="tRNA dimethylallyltransferase"
                     /protein_id="NP_001423965.1"
                     /db_xref="GeneID:362586"
                     /db_xref="RGD:1304781"
                     /translation="MAAAAAARAVPVSSGFRGLPRTLPLVVILGATGTGKSTLALQLG
                     QRLGGEIVSADSMQVYEGLDIITNKVSAQEQKMCRHHMISFVDPLVTSYTVVDFRNRA
                     TALIEDIFARDKIPIVVGGTNYYIESLLWKVLVTTKPQGMGTGKAVDRKVELEKEDGH
                     ELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGVSHSEFLHRQHAEEGGGPLGGP
                     LKFPNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNLKNVSEDSQDYQ
                     HGIFQSIGFKEFHEYLTTEGKCTPETSNQLLKKGVEALKQVTKRYARKQNRWVRNRFL
                     SRPGPSVPPVYGLEVSDVSKWEEFVLEPALSIVQSFIQGSKPTATPVKIPYSETENKR
                     SYHMCDLCDRIIIGDREWAAHTKSKSHLHQLKKRRKLDLDAVSALGSQSNSPDSELER
                     KEGESSGQRDQELKASV"
     misc_feature    83..1132
                     /gene="Trit1"
                     /note="tRNA A37 N6-isopentenylltransferase MiaA
                     [Translation, ribosomal structure and biogenesis]; Region:
                     MiaA; COG0324"
                     /db_xref="CDD:440093"
     misc_feature    83..1132
                     /gene="Trit1"
                     /note="tRNA A37 N6-isopentenylltransferase MiaA
                     [Translation, ribosomal structure and biogenesis]; Region:
                     MiaA; COG0324"
                     /db_xref="CDD:440093"
     misc_feature    1196..1270
                     /gene="Trit1"
                     /note="Zinc-finger double-stranded RNA-binding; Region:
                     zf-C2H2_jaz; pfam12171"
                     /db_xref="CDD:432381"
     misc_feature    1196..1270
                     /gene="Trit1"
                     /note="Zinc-finger double-stranded RNA-binding; Region:
                     zf-C2H2_jaz; pfam12171"
                     /db_xref="CDD:432381"
     exon            188..328
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..427
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..573
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..716
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..828
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..941
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1019
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1129
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1247
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..2077
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgccttc aagatggcgg ctgcggctgc agcacgagcg gttcctgtga gctctggatt
       61 ccgaggcctg ccacgaacac tgccacttgt agtgattctc ggggctactg gcactggcaa
      121 gtccactctg gctcttcaat taggccagcg gctcggcggc gagatcgtca gcgccgactc
      181 catgcaggtc tatgaagggc tagacatcat caccaataag gtctctgccc aggagcagaa
      241 gatgtgccgg caccacatga tcagctttgt ggatccactc gtgaccagct acaccgtggt
      301 agactttagg aacagagcca ctgccctgat tgaagatatt tttgctcgag acaaaattcc
      361 tattgtggtg ggaggaacca attattacat tgagtctctg ctctggaaag ttcttgtgac
      421 taccaagccc caggggatgg gcactgggaa agcggttgat cggaaagtag aacttgaaaa
      481 ggaagatggt catgaactcc ataaacggct aagccaggtg gatccagaaa tggctgccaa
      541 gctacaccca catgacaaac gcaaagtggc caggagcttg caagtgtttg aagaaacagg
      601 agtctctcac agtgaattcc ttcatcgtca acacgcagag gaaggcggtg gtcctcttgg
      661 aggccctctc aagttcccta acccatgcat cctctggctt catgctgacc aggcagttct
      721 agatgagcgc ctggataaga gagtggacga catgcttgct gccggactct tggaagagct
      781 gagagatttt cacagacgct ataatcttaa gaacgtttca gaagatagcc aggactatca
      841 acatggtatc ttccagtcaa ttggcttcaa ggaatttcac gagtacctga ccactgaggg
      901 gaaatgcaca ccagagacta gtaaccagct tctaaagaaa ggggttgagg ctctgaaaca
      961 agtaactaag agatatgccc ggaaacagaa ccgatgggtt agaaaccgct ttttgagcag
     1021 acctggtccc agtgtccccc cggtatatgg cttagaagta tctgatgttt ccaagtggga
     1081 ggagtttgtt ctggagcctg ctctcagtat agtccagagt ttcatccagg gtagcaaacc
     1141 tacagccact ccagtgaaga taccatacag tgaaactgag aacaagagaa gttaccacat
     1201 gtgtgacctt tgtgaccgga tcatcattgg ggaccgggaa tgggcagcac atacaaaatc
     1261 caaatctcac ttgcaccaat tgaagaaaag aagaaagttg gacttggacg ctgtcagtgc
     1321 cttaggaagc caaagtaatt caccagacag tgagctggaa cgcaaagagg gggaatcctc
     1381 aggacagcgt gatcaagagc taaaggccag tgtttgagag acatgcccag tgacctttgc
     1441 agagatgtgg ggatcgagcc caggagggag gggagtgtct ctcttccacg cctggactga
     1501 ggaacgctgg gcagaaagcc ccaccatctt ctttcattct ctggcatgat ctgcacagga
     1561 aacagcaggc ctttcagctc ctcgtgtgcc tgttgtgtct ggtaatgatg tggctcaggg
     1621 taggattttt tttttttctt tgaaccttaa aggttttatt ttagaaagag gcacagattg
     1681 cacattttct acttgaggat cttttttagt ggtgaatacc aagattcagt acatccttta
     1741 aagagagttc ttgtccctgg cactggctaa aaatagtctc atttccagat gcttttgtag
     1801 atgactgaag tattgtaagg cacagtcagg agttctggac aggagaacgg caggaaggag
     1861 tggcccagag agatgagtaa gcgagctgcc ccagctctga atctgcagca gagggggtca
     1921 ggccgaggtg gctgtgacct ggatcgtgaa ggctaatgaa agaatctgtg tcccttgagc
     1981 tgctcctgtg catggtggcc gtcgttgctg gccatctagg gcagacacaa tcagattcct
     2041 ttgaaatgta aataaagatt tgtaaaagcc ctgtagt
//
LOCUS       NM_001108861            1166 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus Yip1 domain family, member 7 (Yipf7), transcript
            variant 1, mRNA.
ACCESSION   NM_001108861 XM_001077453 XM_344236
VERSION     NM_001108861.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 25, 2025 this sequence version replaced NM_001108861.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM118826.1, SRR26643296.33034.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000014.1  38925046-38925088
            44-160              JAXUCZ010000014.1  38926496-38926612
            161-324             JAXUCZ010000014.1  38943454-38943617
            325-470             JAXUCZ010000014.1  38948134-38948279
            471-652             JAXUCZ010000014.1  38950311-38950492
            653-1166            JAXUCZ010000014.1  38952504-38953017
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1166
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Yip1 domain family, member 7"
                     /db_xref="GeneID:364147"
                     /db_xref="RGD:1310766"
     exon            1..43
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            44..160
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..815
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /codon_start=1
                     /product="protein YIPF7"
                     /protein_id="NP_001102331.1"
                     /db_xref="GeneID:364147"
                     /db_xref="RGD:1310766"
                     /translation="MSNPEQYDMDFYQSNYIIDNQEQSYNDSNAYGNFYGSRQPQARE
                     QCQPSSPVPPEMFLSSDYGGQLFQPASNLHYYSQSSSVDSFDEEPPLLEELGINFDHI
                     WQKTLTVLNPMKPADGSIMNETDLTGPILFCVALGATLLMAGKAQFGYIYGMSAIGCF
                     GIHALLNLMSSSGVSYGCVASVLGYCLLPMVILSSCAVFFSLQGTAGTMSALLIITWC
                     SLSASKIFISALAMEGQQLLVAYPCALLYGLFALLTVF"
     misc_feature    <276..812
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Rab GTPase interacting factor, Golgi membrane
                     protein [Intracellular trafficking and secretion]; Region:
                     YIP1; cl46908"
                     /db_xref="CDD:481248"
     misc_feature    <276..812
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /note="Rab GTPase interacting factor, Golgi membrane
                     protein [Intracellular trafficking and secretion]; Region:
                     YIP1; cl46908"
                     /db_xref="CDD:481248"
     exon            161..324
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            325..470
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            471..652
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1166
                     /gene="Yipf7"
                     /gene_synonym="RGD1310766"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtttgttg gaggaccctc cctcatagca tacagagagg taggatgtcg aacccagaac
       61 agtatgacat ggacttctac caatcaaatt atatcattga taatcaggag cagagttata
      121 atgattctaa tgcttacgga aatttctatg gatccagaca accacaagcc cgtgagcagt
      181 gtcaaccttc ctctccagtt ccaccagaga tgttcttgtc atcagattat gggggacagc
      241 tttttcagcc agcgtccaac ttgcattact attcacagtc ttcctcagtt gacagttttg
      301 atgaagagcc tcctttgcta gaggaacttg gaattaattt tgatcacata tggcagaaaa
      361 ccttgacggt gctaaaccca atgaaaccag cagatggcag catcatgaat gaaacagatc
      421 ttacaggacc catccttttc tgtgtggctc tgggagccac gttgcttatg gcaggaaaag
      481 cccagtttgg ttatatctat ggcatgagtg ccattggctg ctttgggatt catgccttac
      541 tgaacttgat gagctcttca ggggtgtcgt atggctgtgt ggccagtgtg ctaggatact
      601 gcttgctccc catggtcatc ttgtccagct gtgcagtttt cttttcactg cagggtaccg
      661 ctggaaccat gtcagccctg ctcatcatca cctggtgcag cctctcagcg tccaagatct
      721 tcatttcagc cttggccatg gaaggacaac agctcctcgt cgcttacccc tgtgccttac
      781 tttatggact ctttgccctt ctgacagttt tctaaagact gcttggcatg gttttgctct
      841 tcagattttt ctggaagtgt gctttcactc agatcctgtg agataacttc catgttatcg
      901 ccgctgagag actattcagc agagagagga gacagcgctc aatgatagtg ctctgctagc
      961 cggttggtgg ggatgatgat gttttgattt ctttagcctg cagcattaaa acagttaaaa
     1021 catttttgaa atattaagag atgcagtctc cgtgctgata gatgctgttt ttctcaacag
     1081 acatgctgct gagaaattat aagcaaaaca ccatcctatg cctaacattt attaactttg
     1141 taataaatat ttttcaaaaa ctttca
//
LOCUS       NM_131907               4946 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ATPase secretory pathway Ca2+ transporting 1
            (Atp2c1), mRNA.
ACCESSION   NM_131907
VERSION     NM_131907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4946)
  AUTHORS   Tang,J., Wang,R., Fan,Y., Zhang,C. and Kong,Y.
  TITLE     Ultrashort wave alleviates oxygen-glucose deprivation/reoxygenation
            injury via up-regulation of SPCA1 expression in N2a cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (5), 641-647 (2023)
   PUBMED   37539566
  REMARK    GeneRIF: Ultrashort wave alleviates oxygen-glucose
            deprivation/reoxygenation injury via up-regulation of SPCA1
            expression in N2a cells.
REFERENCE   2  (bases 1 to 4946)
  AUTHORS   Fan,Y., Zhang,C., Li,T., Peng,W., Yin,J., Li,X., Kong,Y., Lan,C.,
            Wang,R. and Hu,Z.
  TITLE     A New Approach of Short Wave Protection against Middle Cerebral
            Artery Occlusion/Reperfusion Injury via Attenuation of Golgi
            Apparatus Stress by Inhibition of Downregulation of Secretory
            Pathway Ca(2+)-ATPase Isoform 1 in Rats
  JOURNAL   J Stroke Cerebrovasc Dis 25 (7), 1813-1822 (2016)
   PUBMED   27133772
  REMARK    GeneRIF: Short wave therapy protected against focal cerebral I/R
            injury by increasing SPCA1 expression to modulate Golgi apparatus
            stress.
REFERENCE   3  (bases 1 to 4946)
  AUTHORS   Cross,B.M., Hack,A., Reinhardt,T.A. and Rao,R.
  TITLE     SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry
            in a model of lactation
  JOURNAL   PLoS One 8 (6), e67348 (2013)
   PUBMED   23840669
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4946)
  AUTHORS   Leitch,S., Feng,M., Muend,S., Braiterman,L.T., Hubbard,A.L. and
            Rao,R.
  TITLE     Vesicular distribution of Secretory Pathway Ca(2)+-ATPase isoform 1
            and a role in manganese detoxification in liver-derived polarized
            cells
  JOURNAL   Biometals 24 (1), 159-170 (2011)
   PUBMED   20981470
  REMARK    GeneRIF: The secretory pathway Ca(2+)-ATPase isoform 1 (SPCA1) was
            expressed in liver and WIF-B cells.
REFERENCE   5  (bases 1 to 4946)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4946)
  AUTHORS   Fairclough,R.J., Dode,L., Vanoevelen,J., Andersen,J.P.,
            Missiaen,L., Raeymaekers,L., Wuytack,F. and Hovnanian,A.
  TITLE     Effect of Hailey-Hailey Disease mutations on the function of a new
            variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)
  JOURNAL   J Biol Chem 278 (27), 24721-24730 (2003)
   PUBMED   12707275
REFERENCE   7  (bases 1 to 4946)
  AUTHORS   Ton,V.K., Mandal,D., Vahadji,C. and Rao,R.
  TITLE     Functional expression in yeast of the human secretory pathway
            Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease
  JOURNAL   J Biol Chem 277 (8), 6422-6427 (2002)
   PUBMED   11741891
REFERENCE   8  (bases 1 to 4946)
  AUTHORS   Pruitt,K.D. and Maglott,D.R.
  TITLE     RefSeq and LocusLink: NCBI gene-centered resources
  JOURNAL   Nucleic Acids Res 29 (1), 137-140 (2001)
   PUBMED   11125071
REFERENCE   9  (bases 1 to 4946)
  AUTHORS   Hu,Z., Bonifas,J.M., Beech,J., Bench,G., Shigihara,T., Ogawa,H.,
            Ikeda,S., Mauro,T. and Epstein,E.H. Jr.
  TITLE     Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey
            disease
  JOURNAL   Nat Genet 24 (1), 61-65 (2000)
   PUBMED   10615129
REFERENCE   10 (bases 1 to 4946)
  AUTHORS   Gunteski-Hamblin,A.M., Clarke,D.M. and Shull,G.E.
  TITLE     Molecular cloning and tissue distribution of alternatively spliced
            mRNAs encoding possible mammalian homologues of the yeast secretory
            pathway calcium pump
  JOURNAL   Biochemistry 31 (33), 7600-7608 (1992)
   PUBMED   1380825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086994.1.
            
            On Dec 26, 2004 this sequence version replaced NM_131907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4946
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="ATPase secretory pathway Ca2+ transporting 1"
                     /db_xref="GeneID:170699"
                     /db_xref="RGD:621311"
     exon            1..287
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..473
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    435..437
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="upstream in-frame stop codon"
     CDS             468..3227
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /EC_number="7.2.2.10"
                     /note="calcium-transporting ATPase 2C1; ATP-dependent
                     Ca(2+) pump PMR1; ATPase, Ca++-sequestering; secretory
                     pathway Ca(2+)-ATPase 1; ATPase, Ca++ transporting, type
                     2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; secretory pathway
                     Ca(2+)-transporting ATPase type 1"
                     /codon_start=1
                     /product="calcium-transporting ATPase type 2C member 1"
                     /protein_id="NP_571982.2"
                     /db_xref="GeneID:170699"
                     /db_xref="RGD:621311"
                     /translation="MKVARFQKIPNVENETMIPVLTSKRASELAVSEVAGLLQADLQN
                     GLNKSEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMRQFDD
                     AVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDT
                     VCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAF
                     MGTLVRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGI
                     IGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK
                     LPIVETLGCCNVICSDKTGTLTKNEMTVTHILTSDGLHAEVTGVGYNQFGEVIVDGDV
                     VHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKA
                     EYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYNSKGQTLALTQQQRD
                     LYQQEKAQMGSAGLRVLALASGPDLGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSI
                     KMITGDSQETAIAIASRLGLYSKTSQSVSGEEVDTMEVQHLSQIVPKVAVFYRASPRH
                     KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDF
                     QTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINII
                     MDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWREL
                     RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQL
                     LVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVSEIIKKVERSREKTQKNATSTPS
                     SFLEV"
     misc_feature    627..3155
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="golgi-associated secretory pathway Ca(2+) transport
                     ATPases, similar to human ATPase secretory pathway Ca(2+)
                     transporting 1/hSPCA1 and Saccharomyces cerevisiae
                     Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; Region:
                     P-type_ATPase_SPCA; cd02085"
                     /db_xref="CDD:319779"
     misc_feature    627..3155
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="golgi-associated secretory pathway Ca(2+) transport
                     ATPases, similar to human ATPase secretory pathway Ca(2+)
                     transporting 1/hSPCA1 and Saccharomyces cerevisiae
                     Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; Region:
                     P-type_ATPase_SPCA; cd02085"
                     /db_xref="CDD:319779"
     misc_feature    702..752
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    765..830
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    1257..1316
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    1353..1418
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    order(1515..1523,1827..1829,1905..1913,2040..2042,
                     2175..2183,2322..2324,2331..2333,2340..2342,2397..2399,
                     2406..2408)
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319779"
     misc_feature    order(1515..1523,1827..1829,1905..1913,2040..2042,
                     2175..2183,2322..2324,2331..2333,2340..2342,2397..2399,
                     2406..2408)
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319779"
     misc_feature    2568..2636
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    order(2580..2582,2592..2597,2601..2606,2679..2681,
                     2688..2693)
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:319779"
     misc_feature    order(2580..2582,2592..2597,2601..2606,2679..2681,
                     2688..2693)
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="putative cation binding site [ion binding]; other
                     site"
                     /db_xref="CDD:319779"
     misc_feature    2652..2723
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    2796..2852
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    2874..2951
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    2997..3056
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     misc_feature    3096..3146
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64566.1);
                     transmembrane region"
     exon            474..584
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..701
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..791
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..827
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..889
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..998
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1154
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1223
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1299
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1366
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1491
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1589
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1685
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1775
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1880
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2037
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2208
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2306
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2357
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2524
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2593
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2710
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2858
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2954
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3096
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..4915
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcggtgg gcggcgggcg gtgtagtgca gggagcgccg ggcggcgggc ggcagggagg
       61 ggcggagcgc aggaggtgga ggcgggagca gagctgctcg gccgtgcgcg gagacgcgcg
      121 gagccggcgg gccaagcttg acgggcccct cgccgctcct cctctcccct ccctgccacc
      181 atcctgctcg ttctcctccg gacgcggctg ggctccgtgt ggcgccaccg tgccgccagc
      241 agtgcccgtt cgcccgaggc gcgtggggcg cccccgcagc cccgcgaatg ctgctgctag
      301 gggtggtggg agcagccgtg ggacgcgtgg ccgggagcgg gggtgacagc ctgggattcc
      361 agggtcttct cttccttgtc ctcctcctct cctctctatt cccagtgtgg ccgtggctga
      421 cactaaagac tttgtagcca tcaaccagag tgcagtttcg atggaaaatg aaggttgcac
      481 gatttcaaaa gatccctaat gttgaaaatg agacaatgat ccctgtactg acatccaaga
      541 gagcaagtga gttagcagtc agtgaggtcg caggccttct ccaggctgat cttcagaatg
      601 gcttaaacaa atctgaagtt agtcataggc gagccttcca tggctggaat gagtttgata
      661 tcagtgaaga tgaaccatta tggaagaagt acatttctca gtttaaaaat cccctcatca
      721 tgctgcttct ggcttcggca gtcatcagcg ttttaatgcg tcagtttgat gatgccgtca
      781 gtatcactgt ggcaatactg attgttgtca ccgtggcctt tgttcaggaa tatcgttcag
      841 aaaaatcttt agaagaatta agtaaacttg tgccaccaga atgccattgt gttcgtgaag
      901 gaaaattgga gcatacactt gcccgagact tggttccagg tgatacagtt tgtctgtctg
      961 tgggggacag agttcctgct gacttacgct tattcgaggc cgtggatctt tccatcgatg
     1021 agtctagctt gacaggagag acaactcctt gttctaaggt gaccgctcct caaccagctg
     1081 ctaccaatgg ggatcttgca tcaagaagta acattgcctt catggggact ctggtcagat
     1141 gtggcaaagc aaagggtatt gtcattggaa caggagagaa ttctgaattt ggagaggtct
     1201 ttaagatgat gcaggcagaa gaagcaccaa aaacgcctct gcagaagagc atggacctct
     1261 tgggcaagca gctgtccttt tactcctttg gtataatagg tatcatcatg ttggttggct
     1321 ggttactagg gaaagacatt ctggaaatgt tcactattag tgtaagtttg gctgtagctg
     1381 caattcctga aggtctgcct attgtggtca cagtgacact agcccttggt gttatgagaa
     1441 tggtgaagaa aagggctatt gtaaagaaat tgcctattgt tgaaacgctg ggctgctgta
     1501 atgtgatttg ttcagataaa actggaaccc tgacgaagaa tgagatgact gttactcaca
     1561 tcctcacttc agacggcctg catgctgagg ttactggagt tggctacaat cagtttggtg
     1621 aagtgattgt tgatggtgat gttgttcatg gattctataa cccagctgtt agcagaattg
     1681 ttgaggcggg ctgtgtgtgc aacgatgctg tcattaggaa caacactctg atgggaaagc
     1741 caactgaagg agccttaatc gctctcgcga tgaagatggg tcttgatgga ctgcaacaag
     1801 actatatcag aaaagctgaa taccctttta gttctgagca gaaatggatg gctgttaagt
     1861 gtgtgcaccg aacacagcag gacagaccag agatttgttt tatgaagggt gcttatgagc
     1921 aggtgattaa gtattgtact acgtacaaca gcaaagggca gactttggca cttacccagc
     1981 agcagagaga tttgtaccaa caagagaagg cccagatggg ctcggcagga ctccgagttc
     2041 ttgcactggc gtctggtccg gacctggggc agctgacctt ccttggcctg gtaggaatca
     2101 ttgaccctcc gagaactggt gtgaaagaag ccgtcacaac actcattgcc tcaggagtct
     2161 ccatcaaaat gatcacagga gactctcagg agactgcaat tgcaatcgct agtcgtctgg
     2221 gattgtattc taaaacttca cagtctgtgt ctggagaaga agtagataca atggaagtcc
     2281 agcacctttc acagatagtg ccaaaggttg cagtatttta cagagcaagc ccaagacaca
     2341 agatgaaaat tattaagtct ctacaaaaga acgggtcagt tgtagccatg acaggagatg
     2401 gggtaaatga tgcagtggct ctgaaggctg cagatattgg agttgcaatg ggccagactg
     2461 gcacagatgt ttgcaaagag gctgcggaca tgatcttggt ggatgatgat ttccaaacta
     2521 taatgtctgc aatagaagag ggtaaaggca tttataataa cattaaaaat tttgttagat
     2581 ttcaactgag cacgagtata gcagcattaa ctttaatctc attggctacg ttaatgaact
     2641 ttcctaaccc tctcaatgca atgcagattt tgtggatcaa tattataatg gatggacccc
     2701 cagctcagag ccttggagta gagccagtgg ataaagatgt cattcgaaaa ccccctcgga
     2761 actggaagga cagcattttg acaaaaaact tgatccttaa aatacttgtt tcatcaataa
     2821 tcattgtctg tgggactttg tttgtcttct ggcgagagct tcgagacaat gtgataacac
     2881 cccgagacac aacaatgact ttcacttgct tcgtgttttt tgatatgttc aatgcactga
     2941 gttccagatc tcagactaag tctgtgtttg agattggact ctgcagtaat aagatgttct
     3001 gctatgcggt tcttggatcc atcatggggc agttgcttgt tatctacttc ccgcctctgc
     3061 agaaggtttt tcagaccgag agcctcagta ttctggatct gttgtttctt ttgggtctca
     3121 cttcatcagt gtgcattgtg tctgaaatta taaagaaggt tgaaaggagc agggaaaaga
     3181 ctcagaagaa cgctacttca acaccatcgt cttttcttga agtatgatgc atattgcatt
     3241 ttttttttca tttgcaaact aggaattgca gtctgggaat catttagaag ggcaagttca
     3301 agaggataat gaagatttaa ggacttttaa actttccatt gactaaaaat gaccattaat
     3361 gttaaagact tgatttgaac cttgttggta gtcccaaatg aaattatgca actttgaata
     3421 acacgttcct tgatttgaat tggcttttgc aatcgattgg aacttcaaca tatggtcaag
     3481 tactgaatta aaaaagtaca aaaggcaaaa cgtgaacacc ttctgcactt agagttctaa
     3541 tgtacaaata cactatctgt cttagatgga tataaatatt ttttttattt ttaaatattg
     3601 tactatttat ggttgtgggg ctttcttact aatacactca ataaatgcac tcagtcattt
     3661 caaaggcatt ctatttggtt tagaaattgc caggagtgcc atatttcagc taccatgttt
     3721 cctttttcct gcaatgtacg caaatgatac cttgtgctac catttttata tttcaagttt
     3781 tttatttttt atttttgcac aggatgtgac cactgtctaa tcactgttct ttttttttgt
     3841 gactgaaaag catatactgc aattgaagta aatgtttgct cttcttagta agtgtacatg
     3901 gttgttttgg ttttttgtag tggttttcca cagaggtgtg agtctttgac ctagcaggat
     3961 tagttcaggc tgttgttgca ttacagttag agtaattgta cttaacacag tcaaagagtc
     4021 aaaaacaaca aaggctggat ggaatttcaa acagactatg ttaacacgtc cttgtttagg
     4081 ttaatacagt tctactttgt cagtgtcatc ttgtcatttc ttctttataa atcaaacact
     4141 tcagctaaat aattgacctt tattactgtt tcatatttgt atttttaagt ctatttctta
     4201 gagagtatag actaccatac ttagaaaatc aaaagtccca aactcagaga gataggacat
     4261 gaaccagggt gtccatcaga agatcctgtg caggccttgc tcctccgaat cctctaggca
     4321 gccgctttgg cctagattgt agcacaaccc tgagtctgtc ccttctgccg tttgttggga
     4381 tccgtcttct tcttttggta tgcttgggaa atagatggat ttgctttgtg taaaccatca
     4441 gtttttataa gagcttgaca aaataaaggt aagtgttgaa tcttgtattt cataaactgt
     4501 cagaattaac tgttctgagc ttgttcaata ttactggtga gtgttaacgc tgctgcgctg
     4561 tcgttgatag gagaactctg ttgtctgagt ctgtactact gaagcatgaa cgtaaggagc
     4621 cagatgtctg actttgtctt aatctctcag gctcaactgt cagtgtacat tgttctgtct
     4681 cattaggtgg gacgtgaggt cactgtcaac caactcatag aggtttgatg tctcatagca
     4741 aaattttata atggtttttt acattctgtt ccaaacttga aaactacata ttaagtgcat
     4801 attcagtctt gtttgtttta cagtagaggt tgagaatatg actcatgaaa tgaatgtgcc
     4861 tatcttttca cttggtattg aactataaaa ataaagtgag tttttcataa gttcaaaaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
LOCUS       NM_022603               1152 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus fibroblast growth factor binding protein 1
            (Fgfbp1), mRNA.
ACCESSION   NM_022603 XM_006251078
VERSION     NM_022603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1152)
  AUTHORS   Zhu,H.Y., Bai,W.D., Liu,J.Q., Zheng,Z., Guan,H., Zhou,Q., Su,L.L.,
            Xie,S.T., Wang,Y.C., Li,J., Li,N., Zhang,Y.J., Wang,H.T. and
            Hu,D.H.
  TITLE     Up-regulation of FGFBP1 signaling contributes to miR-146a-induced
            angiogenesis in human umbilical vein endothelial cells
  JOURNAL   Sci Rep 6, 25272 (2016)
   PUBMED   27121396
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1152)
  AUTHORS   Yamanaka,Y., Kitano,A., Takao,K., Prasansuklab,A., Mushiroda,T.,
            Yamazaki,K., Kumada,T., Shibata,M., Takaoka,Y., Awaya,T., Kato,T.,
            Abe,T., Iwata,N., Miyakawa,T., Nakamura,Y., Nakahata,T. and
            Heike,T.
  TITLE     Inactivation of fibroblast growth factor binding protein 3 causes
            anxiety-related behaviors
  JOURNAL   Mol Cell Neurosci 46 (1), 200-212 (2011)
   PUBMED   20851768
REFERENCE   3  (bases 1 to 1152)
  AUTHORS   Tassi,E., Walter,S., Aigner,A., Cabal-Manzano,R.H., Ray,R.,
            Reier,P.J. and Wellstein,A.
  TITLE     Effects on neurite outgrowth and cell survival of a secreted
            fibroblast growth factor binding protein upregulated during spinal
            cord injury
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 293 (2), R775-R783 (2007)
   PUBMED   17553847
  REMARK    GeneRIF: FGF-BP is an early response gene after spinal cord injury
            and that its upregulation in regenerating spinal cord tissue may
            provide a molecular mechanism for enhancing the initial
            FGF2-mediated neurotrophic effects occurring after such tissue
            damage
REFERENCE   4  (bases 1 to 1152)
  AUTHORS   Beer,H.D., Bittner,M., Niklaus,G., Munding,C., Max,N., Goppelt,A.
            and Werner,S.
  TITLE     The fibroblast growth factor binding protein is a novel interaction
            partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
            implications for epithelial repair
  JOURNAL   Oncogene 24 (34), 5269-5277 (2005)
   PUBMED   15806171
REFERENCE   5  (bases 1 to 1152)
  AUTHORS   West,D.C., Rees,C.G., Duchesne,L., Patey,S.J., Terry,C.J.,
            Turnbull,J.E., Delehedde,M., Heegaard,C.W., Allain,F.,
            Vanpouille,C., Ron,D. and Fernig,D.G.
  TITLE     Interactions of multiple heparin binding growth factors with
            neuropilin-1 and potentiation of the activity of fibroblast growth
            factor-2
  JOURNAL   J Biol Chem 280 (14), 13457-13464 (2005)
   PUBMED   15695515
REFERENCE   6  (bases 1 to 1152)
  AUTHORS   Aigner,A., Malerczyk,C., Houghtling,R. and Wellstein,A.
  TITLE     Tissue distribution and retinoid-mediated downregulation of an
            FGF-binding protein (FGF-BP) in the rat
  JOURNAL   Growth Factors 18 (1), 51-62 (2000)
   PUBMED   10831072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 26, 2025 this sequence version replaced
            XM_006251078.5, NM_022603.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.30460.1,
                                           SRR26643295.49069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN06680439
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000014.1  71317097-71317151
            56-1152             JAXUCZ010000014.1  71318872-71319968
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1152
                     /gene="Fgfbp1"
                     /note="fibroblast growth factor binding protein 1"
                     /db_xref="GeneID:64535"
                     /db_xref="RGD:621211"
     exon            1..55
                     /gene="Fgfbp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Fgfbp1"
                     /note="upstream in-frame stop codon"
     exon            56..1152
                     /gene="Fgfbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..792
                     /gene="Fgfbp1"
                     /note="FGF-BP; FGF-BP1; FGFBP-1; FGF-binding protein 1;
                     growth factor-binding protein 1"
                     /codon_start=1
                     /product="fibroblast growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_072125.2"
                     /db_xref="GeneID:64535"
                     /db_xref="RGD:621211"
                     /translation="MRIHSLILLSFLLLAAQVLSEKVRKTAKNVPDSTTEEDMSPSLG
                     KARNKQRSRTSKSMTHGKFVTKDQATCRWAVTEEELGINLKVQCTRADQEFSCVFAGD
                     PTGCLKYDKDQTYWKQVARTLRKQKNICENSKSVLKTRVCRKKFPESNLKVVNPRKEK
                     AEVSPREHNKVQEAVSMEPNKVKVDITTSPAATVAVKDSECLEDPDVLTQRKTALEFC
                     GESWSSFCTFFLNMLQATSC"
     sig_peptide     76..135
                     /gene="Fgfbp1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    118..777
                     /gene="Fgfbp1"
                     /note="FGF binding protein 1 (FGF-BP1); Region: FGF-BP1;
                     pfam06473"
                     /db_xref="CDD:461927"
     misc_feature    118..777
                     /gene="Fgfbp1"
                     /note="FGF binding protein 1 (FGF-BP1); Region: FGF-BP1;
                     pfam06473"
                     /db_xref="CDD:461927"
     mat_peptide     136..789
                     /gene="Fgfbp1"
                     /product="Fibroblast growth factor-binding protein 1.
                     /id=PRO_0000245514"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY10.1)"
     misc_feature    148..258
                     /gene="Fgfbp1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY10.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    565..567
                     /gene="Fgfbp1"
                     /note="O-linked (GalNAc...) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9QY10.1);
                     glycosylation site"
     misc_feature    664..789
                     /gene="Fgfbp1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY10.1);
                     Region: Sufficient for interaction with FGF2 and
                     FGF2-induced effects. /evidence=ECO:0000250"
ORIGIN      
        1 gaggactgga agcctgcact tccctgcgca cctggatctg tatactcata gaaaggtgtc
       61 cacccagctg tcgccatgag aatccacagc ctcatcctgc tctctttcct tctcctggct
      121 gctcaggtac tctcggaaaa ggtcagaaag acagccaaga atgtaccaga cagcacaacg
      181 gaggaggata tgtctccctc tttggggaag gcacggaata agcagaggag caggacatcc
      241 aaatctatga cccatggcaa gtttgtcacc aaagaccaag ccacatgcag atgggctgtg
      301 actgaggagg agctgggcat caacctgaag gtccagtgca cacgagccga tcaggagttt
      361 tcttgtgttt tcgctggtga tccaaccggc tgccttaaat acgacaaaga ccagacctac
      421 tggaaacaag tcgcccgcac actgcgcaaa cagaagaata tctgtgagaa ctccaagagt
      481 gtcttgaaga ccagagtgtg cagaaagaaa tttccagagt ctaacctcaa ggtggtaaac
      541 cccaggaagg agaaagcaga ggtctcccca agggagcaca acaaggtcca agaagctgtc
      601 tccatggagc caaacaaggt caaagtggac atcaccacca gcccagctgc gaccgtggct
      661 gtcaaagatt cagagtgtct agaggaccca gatgtcctca cccagaggaa gaccgccctg
      721 gagttctgtg gggaatcttg gagctccttc tgcacattct tcctcaacat gttacaggcc
      781 acatcatgct aacgaagtca gagagagagc agcctaagac atgtggtatc agagccccac
      841 tgtttgctgg aaactccccg ggttcccact aagacacaaa catttccaat acgggaacaa
      901 agtgaagtat ttaaacagat tttgtaaatt ttgttttttg tgtcttagaa tttgctttat
      961 tttgtttttt tacattctta gatgtgcttt tcagagactg tttacctcag cgtaatcttc
     1021 catggactac aaacctaggt tcatataagc agtggatata tacatccaag tgataatgtc
     1081 catgcaagga attgttggct gtatttacca agataataaa gttctgggca ttctcagaaa
     1141 tgccaccaac ca
//
LOCUS       NM_001437304            6647 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus myosin VIIb (Myo7b), mRNA.
ACCESSION   NM_001437304 XM_006254600
VERSION     NM_001437304.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6647)
  AUTHORS   Crawley,S.W., Shifrin,D.A. Jr., Grega-Larson,N.E., McConnell,R.E.,
            Benesh,A.E., Mao,S., Zheng,Y., Zheng,Q.Y., Nam,K.T., Millis,B.A.,
            Kachar,B. and Tyska,M.J.
  TITLE     Intestinal brush border assembly driven by protocadherin-based
            intermicrovillar adhesion
  JOURNAL   Cell 157 (2), 433-446 (2014)
   PUBMED   24725409
REFERENCE   2  (bases 1 to 6647)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254600.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.58999.1,
                                           SRR26643291.40217.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000018.1  23943964-23944078   c
            116-156             JAXUCZ010000018.1  23934490-23934530   c
            157-270             JAXUCZ010000018.1  23924211-23924324   c
            271-423             JAXUCZ010000018.1  23922955-23923107   c
            424-608             JAXUCZ010000018.1  23922077-23922261   c
            609-730             JAXUCZ010000018.1  23920702-23920823   c
            731-873             JAXUCZ010000018.1  23917417-23917559   c
            874-987             JAXUCZ010000018.1  23915919-23916032   c
            988-1141            JAXUCZ010000018.1  23914052-23914205   c
            1142-1218           JAXUCZ010000018.1  23912718-23912794   c
            1219-1338           JAXUCZ010000018.1  23911690-23911809   c
            1339-1481           JAXUCZ010000018.1  23911370-23911512   c
            1482-1692           JAXUCZ010000018.1  23910149-23910359   c
            1693-1828           JAXUCZ010000018.1  23909586-23909721   c
            1829-1998           JAXUCZ010000018.1  23904922-23905091   c
            1999-2136           JAXUCZ010000018.1  23904400-23904537   c
            2137-2289           JAXUCZ010000018.1  23898541-23898693   c
            2290-2388           JAXUCZ010000018.1  23897909-23898007   c
            2389-2483           JAXUCZ010000018.1  23896983-23897077   c
            2484-2568           JAXUCZ010000018.1  23892855-23892939   c
            2569-2787           JAXUCZ010000018.1  23891259-23891477   c
            2788-2958           JAXUCZ010000018.1  23890171-23890341   c
            2959-3168           JAXUCZ010000018.1  23889848-23890057   c
            3169-3336           JAXUCZ010000018.1  23889546-23889713   c
            3337-3464           JAXUCZ010000018.1  23886026-23886153   c
            3465-3591           JAXUCZ010000018.1  23883740-23883866   c
            3592-3711           JAXUCZ010000018.1  23883053-23883172   c
            3712-3885           JAXUCZ010000018.1  23881786-23881959   c
            3886-4113           JAXUCZ010000018.1  23880700-23880927   c
            4114-4281           JAXUCZ010000018.1  23879569-23879736   c
            4282-4399           JAXUCZ010000018.1  23878698-23878815   c
            4400-4526           JAXUCZ010000018.1  23878480-23878606   c
            4527-4690           JAXUCZ010000018.1  23876644-23876807   c
            4691-4872           JAXUCZ010000018.1  23875167-23875348   c
            4873-5003           JAXUCZ010000018.1  23874440-23874570   c
            5004-5161           JAXUCZ010000018.1  23874130-23874287   c
            5162-5315           JAXUCZ010000018.1  23873535-23873688   c
            5316-5471           JAXUCZ010000018.1  23872851-23873006   c
            5472-5577           JAXUCZ010000018.1  23871735-23871840   c
            5578-5691           JAXUCZ010000018.1  23870212-23870325   c
            5692-5779           JAXUCZ010000018.1  23869846-23869933   c
            5780-5886           JAXUCZ010000018.1  23869420-23869526   c
            5887-6072           JAXUCZ010000018.1  23868815-23869000   c
            6073-6189           JAXUCZ010000018.1  23868531-23868647   c
            6190-6273           JAXUCZ010000018.1  23867708-23867791   c
            6274-6393           JAXUCZ010000018.1  23867469-23867588   c
            6394-6647           JAXUCZ010000018.1  23866893-23867146   c
FEATURES             Location/Qualifiers
     source          1..6647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..6647
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="myosin VIIb"
                     /db_xref="GeneID:498834"
                     /db_xref="RGD:1561153"
     exon            1..115
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            116..156
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    130..132
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="upstream in-frame stop codon"
     CDS             139..6483
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /codon_start=1
                     /product="unconventional myosin-VIIb"
                     /protein_id="NP_001424233.1"
                     /db_xref="GeneID:498834"
                     /db_xref="RGD:1561153"
                     /translation="MSVFRLGDHVWLDPPSSNKTGVAIGGIVKETKLGKTLIEDDEGK
                     EHWISAEDLSTLRPMHPNSAQGVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSIL
                     VAVNPFQMLPLYTLEQVQIYYSRHMGELPPHVFAIANSCYFNMKKNKRDQCCIISGES
                     GAGKTETTKLILQFLATVSGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYID
                     IHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEEKNMLGLGMPS
                     EYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
                     AAVFENLDSSDVMETPAFPFAMKLLEVQHQALRDCLIKHTIPILGEFVSRPLNIAQAA
                     DRRDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFE
                     QLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIIS
                     LLDEESRFPQGTDVTMLQKLNSIHANNKSFLRPKSIHDTRFGIAHFAGDVYYQAEGFL
                     EKNRDVLSTDILILIHSSKNKFLKEIFNLDLPQTKLGHGTICQVKTKTGGQIFKPSDS
                     TKRSVTLSSQFKQSLEQLMKILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGM
                     METVHIRKSGFPIRYTFDEFSQRFRVLLPSPERVQFQNKHRQMTSRIADLCLGTDKEW
                     KMGKTKIFLKDHQDTMLEIQRSQALDGAAIRIQRVLRGHKYRKEFLRQKRAAVTLQAV
                     WRGHNQRKNFKLILMGFERLQAIARSHLLMRQFQTMRQKIVQLQARCRGYLVRQQVQA
                     KRRAVVIIQAHARGMVARKSYWQQKSSGPPVILAKEPKGQGVALDRKRKSIYDTVTDT
                     AMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQKLHEVDLDTVPMTEMPGEDVDGLAE
                     YTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALAVWIIILRFMGDLPEPQ
                     AYGRSSLTGSSVMRQIHDRLDKDSVTQGPQHNRSTQVASQQNIGEEVFKFDGPISDRP
                     MSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPS
                     ERFMKYLLNFISQGPASYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
                     LATGRSLTISVDSASTSREICQQIAQKQGLRDKLGFSLQVAVYDKFWSLGNSCDHVMD
                     AVAQCEQLAWERGESQRQAPWRIYFRKEFFTPWHDSREDPVSTELIYHQVLRGVWSGE
                     YNFEKEEDLVELLARHCYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVIAA
                     HAKAPYTQSKATPLEVKEQTVEAARLLWPLLFSRLFEVTTLSGPRLPKTQLILAINWK
                     GMYFLDQKERTLLGLSFAEVMGLIANRDAPGGKSLLLSTLHEEYEFASPSSVAIAEMV
                     ALFLAGLKERSVFAMALQDRKATDDVTLLPFKKGDLLILTKKQGLLASENWVLGQNDR
                     TGKTGLVPTACLYTIPSVTKPSAQLLNLLAMSPEKRKLAAQEVQASEPPLEEQLTELP
                     YTLEEFSYQYFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDS
                     ACQIFLAILKYTGDYPSRQSWHSLELTDQMFSLALKEPALQDELYCQILKQLTHNSIR
                     FSEERAWQLLWLCTGLFPPGKALLPHAQKFIDSRKKKPLALDCSRRLHRILRVGPRKQ
                     PPHHVEVKAAEQNVSKLHHEVYLPNDTNKTLEVSSSSRVRDLCEGIATRLQLASWDGC
                     SLFIKITDKVISLKEGDFFFDSLRQVSDWVKKNRPQKEGASTTLPYQVFFMRKLWLNV
                     TPGKDVNADTILHYHQELPKYMRGFHKCSREDAIYLAGLIYKIQFGSDRSQMASVSKI
                     LKELVPQNLTRLMSSEEWKKSLLLECDKHKNKSVAEAKVEFLKRIYRWPTFGSAFFEV
                     KQTSEPSYPDILLIAINRHGLLLIHPKTKELLDTFPFTKISSWSSGNTYFHMALGSLG
                     QGSRLLCETSLGYKMDDLLTSYVQQILSAVNKHRGFRANP"
     misc_feature    373..2388
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="class VII myosin, motor domain; Region: MYSc_Myo7;
                     cd01381"
                     /db_xref="CDD:276832"
     misc_feature    373..2388
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="class VII myosin, motor domain; Region: MYSc_Myo7;
                     cd01381"
                     /db_xref="CDD:276832"
     misc_feature    order(454..480,610..633,742..774,1447..1464)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276832"
     misc_feature    order(454..480,610..633,742..774,1447..1464)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276832"
     misc_feature    454..480
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    454..480
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    610..633
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="P-loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    610..633
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="P-loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    742..774
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="switch I region; other site"
                     /db_xref="CDD:276832"
     misc_feature    742..774
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="switch I region; other site"
                     /db_xref="CDD:276832"
     misc_feature    1447..1464
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="switch II region; other site"
                     /db_xref="CDD:276832"
     misc_feature    1447..1464
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="switch II region; other site"
                     /db_xref="CDD:276832"
     misc_feature    1534..1605
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="relay loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    1534..1605
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="relay loop; other site"
                     /db_xref="CDD:276832"
     misc_feature    2179..2208
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276832"
     misc_feature    2179..2208
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276832"
     misc_feature    order(2215..2292,2350..2388)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276832"
     misc_feature    order(2215..2292,2350..2388)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276832"
     misc_feature    2497..2565
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Calmodulin-binding motif; Region: IQ; smart00015"
                     /db_xref="CDD:197470"
     misc_feature    2497..2565
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Calmodulin-binding motif; Region: IQ; smart00015"
                     /db_xref="CDD:197470"
     misc_feature    2707..2769
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Calmodulin-binding motif; Region: IQ; smart00015"
                     /db_xref="CDD:197470"
     misc_feature    2707..2769
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Calmodulin-binding motif; Region: IQ; smart00015"
                     /db_xref="CDD:197470"
     misc_feature    3109..3720
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Domain in Myosin and Kinesin Tails; Region: MyTH4;
                     smart00139"
                     /db_xref="CDD:214535"
     misc_feature    3109..3720
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Domain in Myosin and Kinesin Tails; Region: MyTH4;
                     smart00139"
                     /db_xref="CDD:214535"
     misc_feature    3730..4026
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 1, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; Region:
                     FERM1_F1_Myosin-VII; cd17092"
                     /db_xref="CDD:340612"
     misc_feature    3730..4026
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 1, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; Region:
                     FERM1_F1_Myosin-VII; cd17092"
                     /db_xref="CDD:340612"
     misc_feature    3739..4380
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    3739..4380
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    order(3880..3897,3910..3912,3934..3936,4000..4002)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:340612"
     misc_feature    order(3880..3897,3910..3912,3934..3936,4000..4002)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:340612"
     misc_feature    4360..4650
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM domain C-lobe, repeat 1, of Myosin VII
                     (MyoVII/Myo7); Region: FERM_C1_MyoVII; cd13198"
                     /db_xref="CDD:270019"
     misc_feature    4360..4650
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM domain C-lobe, repeat 1, of Myosin VII
                     (MyoVII/Myo7); Region: FERM_C1_MyoVII; cd13198"
                     /db_xref="CDD:270019"
     misc_feature    order(4360..4365,4375..4377,4381..4383,4426..4428,
                     4471..4473)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="CEN1 peptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:270019"
     misc_feature    order(4360..4365,4375..4377,4381..4383,4426..4428,
                     4471..4473)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="CEN1 peptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:270019"
     misc_feature    order(4390..4392,4456..4458,4462..4464,4483..4485)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270019"
     misc_feature    order(4390..4392,4456..4458,4462..4464,4483..4485)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270019"
     misc_feature    4609..4644
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270019"
     misc_feature    4609..4644
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270019"
     misc_feature    4651..4833
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    4651..4833
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(4672..4674,4684..4686,4702..4704,4768..4773,
                     4816..4818,4822..4827)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(4672..4674,4684..4686,4702..4704,4768..4773,
                     4816..4818,4822..4827)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    5074..5517
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Domain in Myosin and Kinesin Tails; Region: MyTH4;
                     smart00139"
                     /db_xref="CDD:214535"
     misc_feature    5074..5517
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Domain in Myosin and Kinesin Tails; Region: MyTH4;
                     smart00139"
                     /db_xref="CDD:214535"
     misc_feature    5536..5829
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 2, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; Region:
                     FERM2_F1_Myosin-VII; cd17093"
                     /db_xref="CDD:340613"
     misc_feature    5536..5829
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 2, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; Region:
                     FERM2_F1_Myosin-VII; cd17093"
                     /db_xref="CDD:340613"
     misc_feature    5542..6180
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    5542..6180
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:214604"
     misc_feature    6166..6453
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM domain C-lobe, repeat 2, of Myosin VII
                     (MyoVII, Myo7); Region: FERM_C2_MyoVII; cd13199"
                     /db_xref="CDD:270020"
     misc_feature    6166..6453
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="FERM domain C-lobe, repeat 2, of Myosin VII
                     (MyoVII, Myo7); Region: FERM_C2_MyoVII; cd13199"
                     /db_xref="CDD:270020"
     misc_feature    order(6190..6192,6253..6255,6259..6261,6277..6279)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270020"
     misc_feature    order(6190..6192,6253..6255,6259..6261,6277..6279)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270020"
     misc_feature    order(6289..6291,6301..6312,6415..6417,6427..6429,
                     6436..6441)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270020"
     misc_feature    order(6289..6291,6301..6312,6415..6417,6427..6429,
                     6436..6441)
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270020"
     misc_feature    6415..6450
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270020"
     misc_feature    6415..6450
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /note="putative actin binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270020"
     exon            157..270
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            271..423
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            424..608
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            609..730
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            731..873
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            874..987
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1141
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1218
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1338
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1481
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1692
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1828
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1998
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2136
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2289
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2388
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2483
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2568
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2787
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2958
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3168
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3336
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3464
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3591
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3711
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3885
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..4113
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4281
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4399
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4526
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4690
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4872
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5003
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5161
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5315
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5316..5471
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5577
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5578..5691
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5692..5779
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5780..5886
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            5887..6072
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            6073..6189
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            6190..6273
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            6274..6393
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
     exon            6394..6647
                     /gene="Myo7b"
                     /gene_synonym="RGD1561153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcctgtcc tttctctccc acactgccag gagctctgaa cctgtctccc tacttggatc
       61 tttcagggtg ccctgggtgg agtcaatagg gtcgctatac tctgatcctg ataaggctga
      121 aggagctgct gacctgggat gtccgtgttc cggctgggtg accatgtgtg gctggaccct
      181 ccctccagca acaagactgg tgtggccatt ggaggcattg tcaaagaaac aaaactgggg
      241 aagaccttga ttgaggatga cgagggcaag gaacactgga tctctgctga agacctcagc
      301 accctcaggc ctatgcaccc caactcggcc caaggagtgg atgacatgat tcgcctgggg
      361 gacctgaatg aggccggtgt ggtacacaac ctcctgatcc gataccagca gcacaagatc
      421 tatacctaca cgggttccat cctggtggcg gtgaacccat tccagatgct gcccctgtac
      481 accctggagc aggtacaaat ctactacagc cgccacatgg gcgagctgcc tccccatgtc
      541 tttgccattg ccaacagctg ctacttcaac atgaagaaga acaagaggga ccagtgttgc
      601 atcatcagtg gtgagtctgg cgctgggaag accgagacca ccaagctcat ccttcagttc
      661 ctggccacag tcagcggcca gcactcgtgg atcgagcagc aggtcctgga ggccaacccc
      721 atcctggaag cctttggcaa tgccaagacc atccgcaatg acaactccag ccgctttggg
      781 aagtacatcg acatccactt caactctagc ggggtgatcg agggggcaag cattgagcac
      841 ttcctactgg aaaagtcgag ggtctgccgg caggctgcgg aggaacggaa ctaccatatt
      901 ttctactgca tgctgatggg gatgagcctg gaagagaaga acatgctggg tctgggcatg
      961 ccctctgagt accactacct gaccatggga aactgcacct cctatgaggg gctcagtgat
     1021 gccaaggact acgcacacgt tcgctcggcc atgaagatcc tccagttctc ggactcggag
     1081 aactgggaca tcagcaagct gctggcagcc atcctccacc tggggaatgt ggggtttatg
     1141 gctgccgtct ttgagaacct ggattcctct gatgtgatgg aaactccggc cttccccttt
     1201 gcaatgaagt tgctagaggt acagcaccag gctctccgag actgtttgat caaacacaca
     1261 atccctatcc ttggagagtt tgtctccagg cccttgaaca tcgcgcaggc tgcagaccgg
     1321 agagatgcct ttgtcaaggg catctacggg cacctcttcc tgtggatcgt caagaagatc
     1381 aatgctgcga tcttcactcc ccaagcccag gatccccaaa atgtgcggag ggccatcggt
     1441 ctcctggaca tatttggctt tgaaaacttt caaaacaaca gcttcgagca actctgcatc
     1501 aatttcgcca acgagcacct tcagcaattc ttcgtgaagc acgtgttcac catggagcag
     1561 gaggagtacc tgtctgagaa catcacttgg aactacatcc actacacgga caaccagccc
     1621 atcctagaca tgctggccct caagcccatg agcatcatct ctctcctgga tgaggagagc
     1681 cgcttcccac aggggacaga tgtcactatg ctgcagaaac tgaacagcat ccatgccaac
     1741 aacaagtcct tcctgagacc caagagcatc catgacaccc gatttgggat cgcacacttt
     1801 gcgggcgatg tatactacca ggcagaaggc tttctggaga agaatcgaga tgtgctgagc
     1861 actgacatcc tcatcctgat tcactcctca aaaaacaagt tcctgaagga gatatttaac
     1921 ctggacttac cacagacaaa gctggggcac ggcaccatct gccaggtgaa gacgaagaca
     1981 ggaggccaga tcttcaagcc atcagactcc accaagcgct ccgtcaccct ctcgagccag
     2041 ttcaagcagt ctctggagca gctgatgaaa atcctgacca attgccagcc ctactttgtc
     2101 cgctgcatca aacccaatga gtacaagaaa ccactgctgt ttgaccgaga gctgtgcatt
     2161 cagcagctgc gttattccgg catgatggag accgtgcaca tccgcaagtc aggctttccc
     2221 atccgctaca cattcgacga gttctcacag aggttccgcg tgctgctgcc tagtccggaa
     2281 cgtgtgcagt ttcaaaacaa gcaccgccag atgacctcgc gcattgctga cctgtgcctg
     2341 gggacggaca aagagtggaa aatgggaaag accaaaatct tcctgaagga tcatcaggac
     2401 acaatgctgg agatccagag gagccaggcc ctggatggag cagcgatccg aatccagaga
     2461 gtccttcggg gacacaaata caggaaggag ttcctgaggc agaaacgggc ggctgtgacc
     2521 ctccaagcag tgtggcgagg ccataaccaa agaaagaatt tcaagctgat cctcatgggt
     2581 tttgaacggc tgcaagccat tgcccggagc cacctgctga tgaggcagtt ccagaccatg
     2641 cgacagaaga tagtgcagct gcaggcccgc tgcaggggct acctggtgcg acagcaagtg
     2701 caggccaaga ggagagcagt ggtgatcatt caagcccatg ccagaggcat ggtggcccgg
     2761 aagagctact ggcaacagaa aagcagtgga cctccagtca tcctggctaa ggagccaaag
     2821 ggccaaggtg tggcccttga caggaagcgt aagtccatct atgacaccgt cactgacaca
     2881 gcaatggtgg agaaagtgtt tggcttcctc ccagctatga ttggaggtca ggagggtcca
     2941 gccccaacac gctttgagga tttggaagta aagacccaga aacttcatga ggttgatctg
     3001 gacacagtgc ccatgacgga gatgccagga gaggatgtgg atggtctggc tgagtatacc
     3061 ttccccaagt ttgctgtaac ttacttccag aaatcagcca gtcacaccca catccagaag
     3121 ccccttcgat acccactcct ctaccatgaa aatgacactg accactcggc agctctggct
     3181 gtttggatca tcatcctgag gttcatgggt gaccttccag aaccacaggc ctatggcagg
     3241 agcagcctga ctggcagctc agttatgcgg cagatccatg acaggctgga caaggacagt
     3301 gtcactcagg gtccacagca caacagatcc acacaggtgg ccagccagca gaacattggt
     3361 gaagaggtgt tcaagtttga tggccctatc tcagacagac ccatgagtaa cttggagaag
     3421 gtgcacttca ttgtgggcta cgccatcatg cgtcctggac tcagagatga aatctactgc
     3481 cagatctgca agcagctctc cgagaactac aaaacaagta gccgggctcg gggctggatc
     3541 ctgctcagcc tctgtctggg ctgcttccca ccctcagaga ggttcatgaa gtatctgctg
     3601 aacttcatta gtcaagggcc agccagctat gggcccttct gtgccgaacg cctgcaacgc
     3661 acctttgcca atggggtgcg tgcagaacct cccacctggc tggagctgca ggctgtcaag
     3721 tccaagaagc acatcccgat ccaggtcatc ctggcaaccg gaaggagcct gaccatctcc
     3781 gtggattctg cctccacatc tcgagaaatc tgccagcaaa ttgctcagaa acagggcctc
     3841 agggacaagc tgggcttctc cctccaggtc gctgtatatg acaagttctg gtccttgggc
     3901 aacagctgtg accatgtgat ggatgctgtg gcccagtgtg agcaactggc ctgggagagg
     3961 ggagagagcc agcgccaggc cccctggcgc atctacttcc ggaaggagtt cttcaccccg
     4021 tggcatgact cccgagagga ccccgtgagc actgagctca tttaccacca agtcctccgg
     4081 ggagtgtggt ctggcgagta taactttgag aaggaagagg acctggtaga gctgctagcc
     4141 cggcactgct atgtgcagct tggggccaca gtgaagagta atgctgtcca ggagctgcta
     4201 cccagctgtg ttccttccaa gctgtaccgc accaagtctc cagagaagtg ggctagcctt
     4261 gtcatcgctg cccatgccaa ggccccgtat acccagtcga aagccacacc attggaggtg
     4321 aaggagcaga cagtggaggc tgcccgtctt ctgtggccac tgctcttctc ccggctattt
     4381 gaagtcacca cactctccgg cccccgcctt cccaagacgc agctgatttt agccattaac
     4441 tggaagggga tgtacttcct ggatcagaag gagaggacac tgctggggtt gtccttcgca
     4501 gaggtcatgg gtctgatcgc caacagggac gccccaggtg ggaagagtct gcttctgtcc
     4561 acactgcatg aagagtacga gttcgcctcc cccagcagcg tggccattgc agagatggtg
     4621 gccttgttcc tggcaggctt gaaggagaga tctgtgttcg ccatggccct gcaggacagg
     4681 aaggccacag atgatgtcac ccttctgccc ttcaagaaag gggacttact gatcctgacc
     4741 aagaaacagg gactgttggc ctcagagaac tgggtcctgg gccagaacga cagaaccggc
     4801 aagacaggac tggtgcccac ggcctgcctc tacaccatcc cctcagtcac caagccctca
     4861 gcccagctgc tgaacttgct ggccatgtcg ccagagaaac ggaagctggc agcccaggag
     4921 gtgcaggctt cggagccacc gctagaggag cagctcacag agttaccgta caccctggag
     4981 gagttctcct accagtattt cagggctcca gagaaagaga ccatcagcag ggcggcgatg
     5041 cccatggccc gaagccgagg ccatctatgg gcctactctc ccgagccgct gcgccagcca
     5101 ctgctcaaat ctgtccacga caaagccaag cttcgagatt cagcctgcca gatcttcctt
     5161 gccatcctca agtacacagg cgactaccca tcccggcagt cctggcacag cctggagctc
     5221 acagaccaga tgttctcgct agccctgaag gagccagccc ttcaggacga gctctactgc
     5281 caaatcctga agcagttgac ccacaactcc atcaggttca gtgaagagag agcctggcag
     5341 ctactgtggc tctgcacagg cctcttccca cctggcaagg cgctgctgcc ccatgcccag
     5401 aagttcatag actcccggaa gaagaagcca ctagctctcg actgcagccg caggctccac
     5461 aggattctaa gggtgggacc tcggaagcag cccccacacc atgtagaggt gaaggccgct
     5521 gagcagaatg tctccaaact acaccatgag gtctacctcc ccaatgacac caataagacc
     5581 ttggaggtga gcagcagtag ccgggtgcga gacctatgtg agggcatcgc cactaggctc
     5641 cagctggcct cctgggatgg ctgcagcctc ttcatcaaga tcacagacaa ggtcatcagc
     5701 ctgaaggaag gagacttctt ttttgacagc ttgaggcagg tatctgactg ggtgaagaag
     5761 aacaggcccc agaaagaagg ggcctccacg acactcccct accaggtgtt cttcatgcgg
     5821 aaactgtggc tcaatgtgac ccctgggaag gacgtgaatg cagacaccat actccattac
     5881 caccaggagc tacccaagta catgcgtggg tttcacaagt gctcccggga agacgccatc
     5941 tacctggcag gcctcatcta taaaatccag tttggcagcg atcgatctca aatggccagt
     6001 gtctcgaaga tcctgaagga gctggtacct cagaacctca cacgcctgat gtcctcagag
     6061 gaatggaaaa agagcctcct tctggaatgt gacaaacaca agaataagtc agtggccgag
     6121 gccaaggtgg aattcctgaa gcggatctac cgatggccta cctttggatc tgccttcttt
     6181 gaggtgaagc aaacctctga gccttcctac ccagacatcc tcctcattgc catcaaccga
     6241 catgggttac tgctcatcca ccccaagacc aaggaactgc tggacacctt ccctttcacc
     6301 aagatctcca gctggagtag cggcaacacc tacttccata tggccttggg gagcctgggc
     6361 cagggcagtc gtttgctgtg tgagacctct ctgggataca agatggacga cctgctcact
     6421 tcatacgtac agcagatcct gagtgcagtg aacaaacatc ggggcttcag ggccaacccc
     6481 taaggggtcc catctgcacc catcttccat gccggccttc tacccacttc tcagcatgcc
     6541 tgactgcccc tcctgggcag tccctgcaga agccaaccaa ggtctcaagc ctcctggcag
     6601 gtggtgggca gctccctgaa tctgcaataa aaatccaccg agcagga
//
LOCUS       NM_001437268            1986 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus PGAM family member 5, mitochondrial
            serine/threonine protein phosphatase (Pgam5), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437268 XM_006249534
VERSION     NM_001437268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Chen,Y., Huang,J., Zhou,H., Lin,J. and Tao,J.
  TITLE     Pgam5 aggravates hyperglycemia-induced myocardial dysfunction
            through disrupting Phb2-dependent mitochondrial dynamics
  JOURNAL   Int J Med Sci 21 (7), 1194-1203 (2024)
   PUBMED   38818468
  REMARK    GeneRIF: Pgam5 aggravates hyperglycemia-induced myocardial
            dysfunction through disrupting Phb2-dependent mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Zhang,J., Li,X., Zhang,Z., Zhang,J., Ma,L., Wang,S., Guo,X., Li,H.,
            Pan,B. and Niu,Q.
  TITLE     Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells
            necroptosis
  JOURNAL   Ecotoxicol Environ Saf 270, 115860 (2024)
   PUBMED   38142589
  REMARK    GeneRIF: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced
            PC12 cells necroptosis.
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Fu,G., Wang,B., He,B., Feng,M. and Yu,Y.
  TITLE     LPS induces cardiomyocyte necroptosis through the Ripk3/Pgam5
            signaling pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 32-37 (2021)
   PUBMED   32580628
  REMARK    GeneRIF: LPS induces cardiomyocyte necroptosis through the
            Ripk3/Pgam5 signaling pathway.
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Liu,G., Qian,M., Chen,M., Chen,T. and Qin,S.
  TITLE     miR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute
            Lung Injury by Directly Targeting PGAM5
  JOURNAL   Biomed Res Int 2020, 4807254 (2020)
   PUBMED   33681349
  REMARK    GeneRIF: miR-21-5p Suppresses Mitophagy to Alleviate
            Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Yang,C., Liu,X., Yang,F., Zhang,W., Chen,Z., Yan,D., You,Q. and
            Wu,X.
  TITLE     Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL
            degradation and controls cardiomyocyte apoptosis driven by
            myocardial ischemia/reperfusion injury
  JOURNAL   In Vitro Cell Dev Biol Anim 53 (3), 248-257 (2017)
   PUBMED   27815660
  REMARK    GeneRIF: PGAM5 controls cardiomyocyte apoptosis induced by MIRI
            through regulating Keap1-mediated Bcl-xL degradation, which may
            supply a novel molecular target for acute myocardial infarction
            (AMI) therapy.
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Sekine,S., Yao,A., Hattori,K., Sugawara,S., Naguro,I., Koike,M.,
            Uchiyama,Y., Takeda,K. and Ichijo,H.
  TITLE     The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers
            Resistance Against Metabolic Stress
  JOURNAL   EBioMedicine 5, 82-92 (2016)
   PUBMED   27077115
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Wei,H., Liu,L. and Chen,Q.
  TITLE     Selective removal of mitochondria via mitophagy: distinct pathways
            for different mitochondrial stresses
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt B), 2784-2790 (2015)
   PUBMED   25840011
  REMARK    Review article
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Wang,Z., Jiang,H., Chen,S., Du,F. and Wang,X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Takeda,K., Komuro,Y., Hayakawa,T., Oguchi,H., Ishida,Y.,
            Murakami,S., Noguchi,T., Kinoshita,H., Sekine,Y., Iemura,S.,
            Natsume,T. and Ichijo,H.
  TITLE     Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic
            activity as a protein serine/threonine phosphatase to activate ASK1
  JOURNAL   Proc Natl Acad Sci U S A 106 (30), 12301-12305 (2009)
   PUBMED   19590015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249534.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.16027.1,
                                           SRR26643429.43815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000012.1  52069073-52069290
            219-397             JAXUCZ010000012.1  52071781-52071959
            398-523             JAXUCZ010000012.1  52072789-52072914
            524-612             JAXUCZ010000012.1  52072997-52073085
            613-743             JAXUCZ010000012.1  52073183-52073313
            744-1986            JAXUCZ010000012.1  52074889-52076131
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1986
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="PGAM family member 5, mitochondrial
                     serine/threonine protein phosphatase"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
     exon            1..218
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..894
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /EC_number="3.1.3.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein phosphatase PGAM5, mitochondrial;
                     phosphoglycerate mutase family member 5"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 2"
                     /protein_id="NP_001424197.1"
                     /db_xref="GeneID:288731"
                     /db_xref="RGD:1312028"
                     /translation="MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDADTRTTEP
                     LAWTGARPGHGVWDSNWDRREPLSLINLKKRNVESGEDELASRLDHYKAKATRHIFLI
                     RHSQYNVDGSMEKDRTLTPLGREQAELTGIRLASLGLKFNKIVHSSMTRAVETTDIIS
                     KHLPGVCRVSTDLLREGAPIEPDPPVSHWKPEAVYYEDGARIEAAFRNYIHRADAKQE
                     EDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDT
                     GFMPPDKITRS"
     misc_feature    49..117
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="propagated from UniProtKB/Swiss-Prot (Q562B5.1);
                     transmembrane region"
     misc_feature    67..885
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; Region: HP; cl11399"
                     /db_xref="CDD:472174"
     misc_feature    67..885
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; Region: HP; cl11399"
                     /db_xref="CDD:472174"
     misc_feature    100..105
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); cleavage site"
     misc_feature    286..288
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); phosphorylation site"
     misc_feature    order(337..342,481..483,712..717)
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     misc_feature    order(337..342,481..483,712..717)
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     misc_feature    373..375
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     misc_feature    457..459
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     misc_feature    598..600
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q562B5.1); acetylation site"
     exon            219..397
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            398..523
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            524..612
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            613..743
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1986
                     /gene="Pgam5"
                     /gene_synonym="RGD1312028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcccgccgt ccggtcgtgc ggcttgcggc atggctttcc ggcaggctct tcagctggcg
       61 gcctgtggtc tggcgggtgg ctcggccgct gttctcttct cggcggtagc ggtagggaag
      121 ccgagagctg gcggggatgc agacacgcgc acgacagagc cgctggcctg gaccggagcg
      181 cgccccgggc acggcgtctg ggactccaac tgggacaggc gagagccact gtcactcatt
      241 aacctgaaga aaaggaacgt ggaatctgga gaagatgaac tggcttccag gctggaccac
      301 tataaggcaa aggctacaag acacatattc ctcatccggc attcccagta caatgtggat
      361 ggctcgatgg agaaggaccg caccctgacc ccattaggtc gggaacaggc tgaactcacg
      421 gggatccgac ttgcaagcct gggactgaag tttaataaaa tcgtccattc ctctatgacc
      481 cgtgcagtag agaccacaga catcatcagt aagcacctgc caggtgtctg cagagtcagc
      541 acagacttgc tacgggaagg tgcccccatt gaaccggatc cacctgtgtc tcactggaag
      601 ccagaggctg tgtattatga agatggagcc cggattgagg ctgccttcag gaactacatc
      661 caccgagctg atgccaagca ggaggaggac agctacgaga tcttcatatg tcacgccaat
      721 gtcatccgtt atattgtttg tagggcactg cagtttcccc cagaaggttg gctccgcctg
      781 tccctcaaca atggtagtat cacccacctg gtgattcgac ccaatggtcg tgttgcactc
      841 aggacccttg gggacacagg gttcatgccc ccagacaaga ttactcggtc ctgaggctgt
      901 ctgtaagact gcaccctgtc ctctgctggt ggcctgccta cagccttccc ttgtcttcca
      961 cagctgtgct gtggcttcac gttcgtctcc agaagaggat atctcaagtg tcacatttgg
     1021 gtgcttactt ctggctcagg ctgaagaagg caacgtatga gttagatggc ctttttgaaa
     1081 gctctctact ttactattac caccagcata gccctaggag gtgcgacagg agccttccta
     1141 ggcagaaggc gggcctgtca cgggtactgt atcacgggat tgtagtagat caaccgaaca
     1201 ctctatgacc tctggaagac ctgtcaggta gtggggtggt gtttacaggt ggttatttca
     1261 ctgcaatcta gggactttgg ttgcttattt atcaaagatt ttcctcatgt gggttcttgc
     1321 tttgaaaacc aacttctcag ctcaattagg agattctgtg tctactgcat ttgaatgatg
     1381 gacaaagggg ctggcttcct ataaggtaga taaaagccaa gaaagtggca ctgctaaagg
     1441 actgtggcct gtataaggca agtaggtgat agttctgtaa gaggttcctt ggaagcaaag
     1501 atagccccac tgaccagaag aggtggcata tacttgtaat tctagcatct gggaggcaga
     1561 agcaggatcg tgagtctcta gccagcctga gttatgttaa aagacccaga aaaatatccc
     1621 tgagtgacgg ttccatttta gtttgctact gttaaccttg aacttgtagg ttatttagaa
     1681 atgatgtgtt tattccagat attctgataa gaaaaaaatg gtttttgtat gtgtggtttt
     1741 tgtttttgtg acagaatctt aactgttgcc caggctggct tcaaacttga gacccttctg
     1801 agtcttgtaa ttgttgggat tgcaggtata tactaccaca cctgtccgtt cgtcccccta
     1861 tcctccaaaa aacccagtac agtttctatg aaatggttgt gagcatcttc tgtaatcaat
     1921 gcaatgaatt ggaatatttg atgtatctct ctgccctctt tggaaataat aaaattttac
     1981 tttgtt
//
LOCUS       NM_001437512            3677 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus colony stimulating factor 1 receptor (Csf1r),
            transcript variant 1, mRNA.
ACCESSION   NM_001437512 XM_006254813
VERSION     NM_001437512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3677)
  AUTHORS   Hume,D.A., Teakle,N., Keshvari,S. and Irvine,K.M.
  TITLE     Macrophage deficiency in CSF1R-knockout rat embryos does not
            compromise placental or embryo development
  JOURNAL   J Leukoc Biol 114 (5), 421-433 (2023)
   PUBMED   37167456
  REMARK    GeneRIF: Macrophage deficiency in CSF1R-knockout rat embryos does
            not compromise placental or embryo development.
REFERENCE   2  (bases 1 to 3677)
  AUTHORS   Sehgal,A., Carter-Cusack,D., Keshvari,S., Patkar,O., Huang,S.,
            Summers,K.M., Hume,D.A. and Irvine,K.M.
  TITLE     Intraperitoneal transfer of wild-type bone marrow repopulates
            tissue macrophages in the Csf1r knockout rat without contributing
            to monocytopoiesis
  JOURNAL   Eur J Immunol 53 (8), e2250312 (2023)
   PUBMED   37059596
  REMARK    GeneRIF: Intraperitoneal transfer of wild-type bone marrow
            repopulates tissue macrophages in the Csf1r knockout rat without
            contributing to monocytopoiesis.
REFERENCE   3  (bases 1 to 3677)
  AUTHORS   Keshvari,S., Caruso,M., Teakle,N., Batoon,L., Sehgal,A.,
            Patkar,O.L., Ferrari-Cestari,M., Snell,C.E., Chen,C., Stevenson,A.,
            Davis,F.M., Bush,S.J., Pridans,C., Summers,K.M., Pettit,A.R.,
            Irvine,K.M. and Hume,D.A.
  TITLE     CSF1R-dependent macrophages control postnatal somatic growth and
            organ maturation
  JOURNAL   PLoS Genet 17 (6), e1009605 (2021)
   PUBMED   34081701
  REMARK    GeneRIF: CSF1R-dependent macrophages control postnatal somatic
            growth and organ maturation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3677)
  AUTHORS   Patkar,O.L., Caruso,M., Teakle,N., Keshvari,S., Bush,S.J.,
            Pridans,C., Belmer,A., Summers,K.M., Irvine,K.M. and Hume,D.A.
  TITLE     Analysis of homozygous and heterozygous Csf1r knockout in the rat
            as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations
  JOURNAL   Neurobiol Dis 151, 105268 (2021)
   PUBMED   33450391
  REMARK    GeneRIF: Analysis of homozygous and heterozygous Csf1r knockout in
            the rat as a model for understanding microglial function in brain
            development and the impacts of human CSF1R mutations.
REFERENCE   5  (bases 1 to 3677)
  AUTHORS   Sharon,A., Jankowski,M.M., Shmoel,N., Erez,H. and Spira,M.E.
  TITLE     Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat
            Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and
            Its Implications
  JOURNAL   Front Neurosci 15, 646914 (2021)
   PUBMED   33841088
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3677)
  AUTHORS   Storga,D., Pecina-Slaus,N., Pavelic,J., Pavelic,Z.P. and Pavelic,K.
  TITLE     c-fms is present in primary tumours as well as in their metastases
            in bone marrow
  JOURNAL   Int J Exp Pathol 73 (4), 527-533 (1992)
   PUBMED   1390197
REFERENCE   7  (bases 1 to 3677)
  AUTHORS   Borycki,A.G., Guillier,M., Leibovitch,M.P. and Leibovitch,S.A.
  TITLE     Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence
            analysis and regulation during myogenesis
  JOURNAL   Growth Factors 6 (3), 209-218 (1992)
   PUBMED   1389227
REFERENCE   8  (bases 1 to 3677)
  AUTHORS   Claycomb,W.C. and Lanson,N.A. Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   9  (bases 1 to 3677)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 3677)
  AUTHORS   Sherr,C.J., Rettenmier,C.W., Sacca,R., Roussel,M.F., Look,A.T. and
            Stanley,E.R.
  TITLE     The c-fms proto-oncogene product is related to the receptor for the
            mononuclear phagocyte growth factor, CSF-1
  JOURNAL   Cell 41 (3), 665-676 (1985)
   PUBMED   2408759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254813.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.495349.1,
                                           SRR26360186.2720224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000018.1  56834271-56834427
            158-415             JAXUCZ010000018.1  56838153-56838410
            416-700             JAXUCZ010000018.1  56838717-56839001
            701-837             JAXUCZ010000018.1  56840670-56840806
            838-997             JAXUCZ010000018.1  56841407-56841566
            998-1184            JAXUCZ010000018.1  56844188-56844374
            1185-1300           JAXUCZ010000018.1  56846766-56846881
            1301-1421           JAXUCZ010000018.1  56847022-56847142
            1422-1612           JAXUCZ010000018.1  56847259-56847449
            1613-1728           JAXUCZ010000018.1  56848724-56848839
            1729-1855           JAXUCZ010000018.1  56853763-56853889
            1856-1960           JAXUCZ010000018.1  56854006-56854110
            1961-2071           JAXUCZ010000018.1  56854387-56854497
            2072-2234           JAXUCZ010000018.1  56855134-56855296
            2235-2323           JAXUCZ010000018.1  56857334-56857422
            2324-2421           JAXUCZ010000018.1  56857539-56857636
            2422-2544           JAXUCZ010000018.1  56858446-56858568
            2545-2656           JAXUCZ010000018.1  56858645-56858756
            2657-2756           JAXUCZ010000018.1  56859399-56859498
            2757-2865           JAXUCZ010000018.1  56859804-56859912
            2866-3677           JAXUCZ010000018.1  56859996-56860807
FEATURES             Location/Qualifiers
     source          1..3677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3677
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="colony stimulating factor 1 receptor"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
     exon            1..157
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="upstream in-frame stop codon"
     CDS             109..3045
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; macrophage colony-stimulating factor 1
                     receptor; fms proto-oncogene; proto-oncogene fms;
                     proto-oncogene c-Fms; CSF-1 receptor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 receptor
                     isoform 1 precursor"
                     /protein_id="NP_001424441.1"
                     /db_xref="GeneID:307403"
                     /db_xref="RGD:2425"
                     /translation="MELGAPLVLLLATAWHGQGAPVIEPSGPELVVEPGATVTLRCVS
                     NGSVEWDGPISPYWTLDSESPGSILITKNATFKNTGTYRCTELEDPMRGSTAIHLYVK
                     DPVRPWNLLAQEVTVFEGQEAVLPCLITDPTLKDSVSLVREWGRPVSRKTVYSFLPWR
                     GFIIHKAKFLDSHTYMCKAVVNARESTSIGIRLKVNRAHPGPPHIILEPTKLVRIRGE
                     AAQIVCSATHSEVEFNVILKRGDTKLEIPINSDFQDNAYKKVLTLNLNAVDFQDAGIY
                     SCVANNAAGSNTATMNFQVVESAYLNLTSEQSLLQEVSVGENLDLTVIADAYPGLQRY
                     NWTYLGPFFEDPHNLEFRTQWTTYSYSFKLHLNRVKPLEAGRYSLMAQNKAGWNNLTF
                     ELTLRYPPEVSVTWIPVNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDD
                     TQPEVLSQKPFHRVILQSQLPIGTLKHNMTYVCRAHNNVGNSSQFFRAISLGQSKQLP
                     DEYLFTPVVVACISVMSLLVLLLLLLLYKYKQKPKYQVRWKIIESYEGNNYTFIDPTQ
                     LPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE
                     KEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLG
                     PSLSPGQDPEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFFKQDL
                     DKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLA
                     RDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG
                     ILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICFLLQEQARL
                     ERREQDYANLPSSSSSSSSSSDSGGGSGGSSSEPEEESSSEHLACCEPGDIAQPLLQP
                     NNYQFC"
     sig_peptide     109..165
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    190..411
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    190..411
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    220..234
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    220..234
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    271..282
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    271..282
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    304..318
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    304..318
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    370..381
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    370..381
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    445..693
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    445..693
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin like; Region: IG_like; smart00410"
                     /db_xref="CDD:214653"
     misc_feature    715..993
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    715..993
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    766..780
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    766..780
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    808..822
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    808..822
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    883..897
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    883..897
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    931..948
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    931..948
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    970..981
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    970..981
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1003..1302
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1003..1302
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1063..1077
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1063..1077
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1105..1119
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1105..1119
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1192..1206
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1192..1206
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1234..1251
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1234..1251
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1273..1284
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1273..1284
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1303..1569
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    1303..1569
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Immunoglobulin domain; Region: Ig_3; pfam13927"
                     /db_xref="CDD:464046"
     misc_feature    1729..2847
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Colony-Stimulating Factor-1 Receptor; Region: PTKc_CSF-1R;
                     cd05106"
                     /db_xref="CDD:133237"
     misc_feature    1729..2847
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Colony-Stimulating Factor-1 Receptor; Region: PTKc_CSF-1R;
                     cd05106"
                     /db_xref="CDD:133237"
     misc_feature    order(1864..1869,1873..1884,1888..1890,1942..1944,
                     1948..1950,2092..2094,2098..2100,2110..2112,2434..2436,
                     2446..2451,2455..2457,2488..2490,2542..2556,2581..2583,
                     2686..2688)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="active site"
                     /db_xref="CDD:133237"
     misc_feature    order(1864..1869,1873..1884,1888..1890,1942..1944,
                     1948..1950,2092..2094,2098..2100,2110..2112,2434..2436,
                     2446..2451,2455..2457,2488..2490,2542..2556,2581..2583,
                     2686..2688)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="active site"
                     /db_xref="CDD:133237"
     misc_feature    order(1864..1869,1873..1884,1888..1890,1942..1944,
                     1948..1950,2092..2094,2098..2100,2110..2112,2446..2451,
                     2455..2457,2488..2490)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(1864..1869,1873..1884,1888..1890,1942..1944,
                     1948..1950,2092..2094,2098..2100,2110..2112,2446..2451,
                     2455..2457,2488..2490)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(2434..2436,2446..2448,2542..2556,2581..2583,
                     2686..2688)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    order(2434..2436,2446..2448,2542..2556,2581..2583,
                     2686..2688)
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133237"
     misc_feature    2485..2562
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133237"
     misc_feature    2485..2562
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133237"
     exon            158..415
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            416..700
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            701..837
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            838..997
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1184
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1300
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1421
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1612
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1728
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1855
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1960
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2071
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2234
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2323
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2421
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2544
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2656
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2756
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2865
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3677
                     /gene="Csf1r"
                     /gene_synonym="c-fms; CSF-1-R; CSF-1R; M-CSF-R; mrfms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaagaac gtgttcctct gttcccatcc ctacagagtt agcagctggg agccctgtgc
       61 ccagccgact ttccaacctg catcgtccca cgctaacccc tggaggctat ggagctgggg
      121 gctcctctgg tcctgctgct ggccacagct tggcatggtc aaggggcccc tgtcatcgag
      181 cctagtggcc cagagctggt tgtagagcca ggtgcaacag tgaccctgcg atgtgtgagc
      241 aatggcagtg tggaatggga tggccccatc tctccctact ggaccttgga ctctgaatct
      301 cctggaagca tcctgatcac aaaaaacgcc accttcaaaa acactgggac ctaccgttgt
      361 actgagcttg aagaccctat gcggggcagt accgccatcc acttgtacgt caaagatcct
      421 gtccggccct ggaatttgct agcacaggag gtgacagtgt ttgagggcca ggaagctgtg
      481 ctgccctgtc tgatcactga ccccacactg aaggacagtg tctcactggt gagggagtgg
      541 ggcagaccag tctcacgcaa aacggtctac tccttcttac catggcgagg gttcattatc
      601 cacaaggcta aattccttga cagtcatacc tacatgtgca aggctgttgt gaacgctagg
      661 gaatccacct ccattggcat ccggcttaag gtgaatcgag cccacccagg gcccccacac
      721 atcatattgg aacctactaa gctggtgagg attcgagggg aggctgccca gatcgtgtgc
      781 tcggccactc actcagaagt tgaattcaac gttatcctca aacgtggaga caccaagttg
      841 gaaatcccca taaacagtga cttccaagac aacgcttata aaaaggtcct gactcttaac
      901 ctcaatgctg tggacttcca agatgctggc atatattcct gtgtggccaa caacgcagct
      961 ggctcgaaca cggccaccat gaacttccag gtggtggaga gtgcctactt aaacttgacc
     1021 tctgagcaga gcctcttgca ggaggtgtct gtgggtgaga acctcgacct cacagtcatt
     1081 gcagatgcct accctggcct acagcgttac aactggacct acctagggcc gttctttgaa
     1141 gacccacaca atcttgagtt tagaacccaa tggaccacat acagctactc attcaaactc
     1201 cacctgaacc gtgtaaagcc cttggaggcc ggccgctact ccttaatggc acaaaacaag
     1261 gcaggctgga ataatctgac ctttgagctc accctgcgat accccccaga agtcagtgtt
     1321 acatggatac ctgtgaacgg ctctgatgtc ctgctctgtg atgtctctgg gtatcctcag
     1381 cccaacgtga catggatgga gtgcaggggc cacaccgata ggtgtgatga ggcccaggcc
     1441 tcgcaggttt gggatgacac acaacctgaa gtcctgagtc agaagccctt ccacagagtg
     1501 atccttcaga gccagctgcc cattgggacc ctaaagcaca acatgactta tgtttgcaga
     1561 gcccacaaca atgtgggtaa cagctcccag ttcttcaggg ccatctccct aggacaaagc
     1621 aagcagctcc ctgatgagta cctgttcact ccagtggtgg tggcctgtat atctgtcatg
     1681 tctctgctgg tactactgct gctgctgctc ttgtacaagt acaagcagaa gccgaaatat
     1741 caggtgcgct ggaagatcat tgagagctac gagggcaaca actacacctt catcgaccct
     1801 acccagttgc cctacaatga gaagtgggag tttccccgga acaacctgca atttggtaag
     1861 actctcggag ctggtgcctt tgggaaggtg gtggaggcca cagcctttgg tctgggcaaa
     1921 gaagatgcag tgctgaaggt ggctgtgaag atgctcaagt ccacggctca tgccgatgag
     1981 aaggaggccc taatgtcaga actgaagatc atgagtcacc tgggacagca tgagaacatt
     2041 gtcaacctct tgggagcctg tactcatgga gggcctgtcc tggtcatcac cgaatactgc
     2101 tgctacggag accttctcaa cttccttcga aggaaggccg aggctatgct gggacccagc
     2161 ctgagtcctg gtcaggaccc cgagggggac tccagctaca agaacatcca cctggagaag
     2221 aaatatgtgc gcagggacag tggcttctcc agtcagggcg tagataccta tgtggagatg
     2281 aggcctgttt cgacttcctc aaatgactcc ttctttaagc aagatctgga caaagaggcc
     2341 agccggccgc tggagctctg ggacctgctt cacttctcta gccaagtggc tcagggcatg
     2401 gctttccttg cttctaaaaa ttgcatccat cgtgatgtag ctgctcgaaa tgtgctgttg
     2461 accagcggac atgtggccaa gattggggac tttgggctgg ctagggacat catgaatgac
     2521 tctaactatg ttgtcaaggg caatgcccgc ctgcctgtaa agtggatggc cccagagagc
     2581 atcttcgact gcgtctacac agttcagagt gatgtgtggt cctacggcat cctcctctgg
     2641 gagattttct cacttggtct gaacccctac ccaggcatct tagtgaacaa caagttctac
     2701 aaactggtga aggatggata ccaaatggcc cagcctgtat ttgcaccgga gaacatatac
     2761 agcatcatgc agtcctgctg ggacctggag cctaccaaaa gacctacctt ccagcagatc
     2821 tgcttcctcc tccaggaaca ggcccgactg gagaggagag agcaggacta tgctaacctg
     2881 ccaagcagca gcagcagcag tagcagcagc agtgacagtg gtggtggcag tggtggtagc
     2941 agcagtgagc ctgaagagga gagctccagt gagcacctgg cctgctgtga gccaggggac
     3001 atcgcccagc ccctgctgca gcctaacaac taccagttct gctgaagcgg gacagcagag
     3061 tcctgctgcc ctccacgtcc cagctcgacc tcctccatgg atgggcgaca tggggagagc
     3121 atatgaactt cgtcctcagc tcggcccagc tctgacgctt ctgaacatga ggggttccca
     3181 gagcctgggc catcactgcc agtggggttc tcacagtgct agcctctatt tactacacca
     3241 actggtgaac ccatacttca ctttcttcat cctgttccca cttgaaaaaa ctgtccccaa
     3301 ctctcgtttc aatggaaaga ctgatttgtg tctcaaaaag acaggtctca ggttgtaggt
     3361 gagcagaagc ttgcctccct gacagaggct cagactgcag gcttcttggg gcaggcggcc
     3421 cttcccaagc tcacagactg gtcgccactc ttaccttctc tttatctaca gtcccgtctc
     3481 atcctggatc ttgtacacta ggagcccagt ggcagctgag agccagggat gctttactta
     3541 gtgccctgca ttctaggctg gcaggcatgg gaccttggtg caaggctgac aacgccaagc
     3601 aaatactgcg tgctcctctc caaactgact cgtcctcatt aacagtcaac attaaactaa
     3661 cagcattaac acagcca
//
LOCUS       NM_001437333            1932 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus SEH1-like nucleoporin (Seh1l), transcript variant
            3, mRNA.
ACCESSION   NM_001437333 XM_056984931
VERSION     NM_001437333.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Parmigiani,A., Nourbakhsh,A., Ding,B., Wang,W., Kim,Y.C.,
            Akopiants,K., Guan,K.L., Karin,M. and Budanov,A.V.
  TITLE     Sestrins inhibit mTORC1 kinase activation through the GATOR complex
  JOURNAL   Cell Rep 9 (4), 1281-1291 (2014)
   PUBMED   25457612
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Bonnet,A. and Palancade,B.
  TITLE     Regulation of mRNA trafficking by nuclear pore complexes
  JOURNAL   Genes (Basel) 5 (3), 767-791 (2014)
   PUBMED   25184662
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Ahn,S.H., Deshmukh,H., Johnson,N., Cowell,L.G., Rude,T.H.,
            Scott,W.K., Nelson,C.L., Zaas,A.K., Marchuk,D.A., Keum,S.,
            Lamlertthon,S., Sharma-Kuinkel,B.K., Sempowski,G.D. and Fowler,V.G.
            Jr.
  TITLE     Two genes on A/J chromosome 18 are associated with susceptibility
            to Staphylococcus aureus infection by combined microarray and QTL
            analyses
  JOURNAL   PLoS Pathog 6 (9), e1001088 (2010)
   PUBMED   20824097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Zuccolo,M., Alves,A., Galy,V., Bolhy,S., Formstecher,E., Racine,V.,
            Sibarita,J.B., Fukagawa,T., Shiekhattar,R., Yen,T. and Doye,V.
  TITLE     The human Nup107-160 nuclear pore subcomplex contributes to proper
            kinetochore functions
  JOURNAL   EMBO J 26 (7), 1853-1864 (2007)
   PUBMED   17363900
REFERENCE   7  (bases 1 to 1932)
  AUTHORS   Glavy,J.S., Krutchinsky,A.N., Cristea,I.M., Berke,I.C., Boehmer,T.,
            Blobel,G. and Chait,B.T.
  TITLE     Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
            subcomplex
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3811-3816 (2007)
   PUBMED   17360435
REFERENCE   8  (bases 1 to 1932)
  AUTHORS   Loiodice,I., Alves,A., Rabut,G., Van Overbeek,M., Ellenberg,J.,
            Sibarita,J.B. and Doye,V.
  TITLE     The entire Nup107-160 complex, including three new members, is
            targeted as one entity to kinetochores in mitosis
  JOURNAL   Mol Biol Cell 15 (7), 3333-3344 (2004)
   PUBMED   15146057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 2, 2025 this sequence version replaced XM_056984931.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.291576.1,
                                           SRR22399492.2302238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000018.1  63616923-63617115
            194-244             JAXUCZ010000018.1  63621318-63621368
            245-391             JAXUCZ010000018.1  63624767-63624913
            392-603             JAXUCZ010000018.1  63626014-63626225
            604-702             JAXUCZ010000018.1  63628455-63628553
            703-843             JAXUCZ010000018.1  63632848-63632988
            844-1001            JAXUCZ010000018.1  63633520-63633677
            1002-1152           JAXUCZ010000018.1  63636252-63636402
            1153-1932           JAXUCZ010000018.1  63639073-63639852
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1932
                     /gene="Seh1l"
                     /note="SEH1-like nucleoporin"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
     exon            1..193
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1345
                     /gene="Seh1l"
                     /note="isoform 3 is encoded by transcript variant 3;
                     nucleoporin SEH1; nucleoporin SEH1-like"
                     /codon_start=1
                     /product="nucleoporin SEH1 isoform 3"
                     /protein_id="NP_001424262.1"
                     /db_xref="GeneID:100911798"
                     /db_xref="RGD:6490353"
                     /translation="MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSES
                     GDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSH
                     WVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRVYEAPDVMNLSQWSLQHEIS
                     CKLCCSCISWNPSSSRAHPPMIAVGSDDSSPNSMAKVQIFEYNENTRKYAKAETLMTV
                     TDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDN
                     HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQLGN
                     STPSLSSNIPNLQNSLNGTSAGRYFFPPLDSPRAGSRWSSCAQLLPPPAPLLEHSCDA
                     DTANLHYPHPRRGCLSRPLNPLPENEGV"
     misc_feature    <113..1066
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <113..1066
                     /gene="Seh1l"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    125..247
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    125..247
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    263..415
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    263..415
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    428..529
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    428..529
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    578..718
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    578..718
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    746..883
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    746..883
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1042
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1042
                     /gene="Seh1l"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            194..244
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            245..391
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            392..603
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            604..702
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            703..843
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1001
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1152
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1932
                     /gene="Seh1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgtgcct ctgccgcggt ccgggggctg cgggccgcac cgccgccctc tcggaggcgg
       61 gcccgggcag acggcggcgg ccatgtttgt ggcgcgcagc atcgcggcgg accacaagga
      121 cctcatccac gatgtgtctt tcgacttcca cgggcgccgg atggccacct gttccagcga
      181 ccagagcgtc aaggtgtggg ataagagcga gagcggagat tggcactgca cagctagttg
      241 gaagacacat agtggatctg tatggcgtgt gacatgggct catcctgagt ttggacaagt
      301 tttggcttcc tgttcttttg accgaacagc agccgtatgg gaagaaatag taggagagtc
      361 aaacgataaa cttcgaggac agagtcactg ggtgaaaagg acaactctag tggacagcag
      421 aacatctgtt acagatgtga aatttgctcc caagcacatg ggtctgatgt tagcaacctg
      481 ctctgcagat ggcatcgtga gagtctacga ggccccagat gtgatgaacc tcagccagtg
      541 gtccctgcag cacgagatct cgtgtaagct gtgctgcagc tgcatttctt ggaacccttc
      601 cagctctcgt gctcaccccc ccatgatcgc tgtgggaagt gatgacagca gtccaaattc
      661 aatggccaag gttcagatct ttgagtacaa tgaaaacacc aggaaatatg caaaagctga
      721 gactcttatg acagtcacgg atcctgtcca tgacattgcg tttgctccaa atttgggacg
      781 atctttccac atcctggcaa tagcaaccaa agatgtaaga attttcacat taaaacctgt
      841 gaggaaagaa cttacttctt ctggtggtcc aacaaaattt gaaatccata ttgtggctca
      901 gtttgataat cataattctc aggtctggag ggtgagttgg aacataacag gaacagtatt
      961 ggcgtcttca ggagatgacg gctgtgttag gttgtggaaa gctaattaca tggacaattg
     1021 gaagtgcact ggtattttga aaggtaacgg gagcccagta aatgggagtt ctcagctggg
     1081 aaactcaact ccttcactga gctcaaatat tccaaatctt caaaattcat taaatggaac
     1141 atctgctggc aggtatttct ttccccctct ggattcccca cgggctggat caagatggtc
     1201 cagctgtgcc cagctccttc ctcctcctgc tcctctgcta gagcactctt gtgatgcaga
     1261 cactgccaac ctccactatc ctcaccctcg cagaggatgc ctctctcggc ctcttaatcc
     1321 cttacctgag aatgaagggg tgtaaaatcc tgatttaaag gccttaccca gatgcttgta
     1381 aatgctttta ttccgggctg cttttggttt cttcattttc ttttagaaga tccttcctag
     1441 ttaggccatg tcttgcatgt atcacaactc gagtgtttga aaccaaacct gtttgtactt
     1501 ctgcaccagg aaaccttggc ttcactagtt ggttaccttg gacgagatga gcttcagaaa
     1561 aagcaatatt aactgtgaac gattcccagt atctggttca aagtgcctgt cttgtacatt
     1621 cattctgtgt ggacttgtta tcatagagtt cagttttgtc tgttgatggt agcttcagag
     1681 gaaagcatat cattgtgaac ttcactctgt aattcagaca ttaagaaatg tttggaattt
     1741 tataggctga tgttacaaat gactgtaaaa taaatcattc ctgtgtataa agcagcaaat
     1801 cataaggata tttttgtctt tttttttttt ttttaaagga aaatgccttt tactacttgg
     1861 aattactact taaaaatttt gtaactgttc tccaagtagg ttatttaata aaagtatttt
     1921 aaaagatgtg aa
//
LOCUS       NM_001436897            2027 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ceramide-1-phosphate transfer protein (Cptp),
            transcript variant 1, mRNA.
ACCESSION   NM_001436897 XM_006239576
VERSION     NM_001436897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2027)
  AUTHORS   Mishra,S.K., Gao,Y.G., Deng,Y., Chalfant,C.E., Hinchcliffe,E.H. and
            Brown,R.E.
  TITLE     CPTP: A sphingolipid transfer protein that regulates autophagy and
            inflammasome activation
  JOURNAL   Autophagy 14 (5), 862-879 (2018)
   PUBMED   29164996
REFERENCE   2  (bases 1 to 2027)
  AUTHORS   Simanshu,D.K., Kamlekar,R.K., Wijesinghe,D.S., Zou,X., Zhai,X.,
            Mishra,S.K., Molotkovsky,J.G., Malinina,L., Hinchcliffe,E.H.,
            Chalfant,C.E., Brown,R.E. and Patel,D.J.
  TITLE     Non-vesicular trafficking by a ceramide-1-phosphate transfer
            protein regulates eicosanoids
  JOURNAL   Nature 500 (7463), 463-467 (2013)
   PUBMED   23863933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006239576.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.25180.1,
                                           SRR26643292.24630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000005.1  171760996-171761230 c
            236-460             JAXUCZ010000005.1  171758958-171759182 c
            461-2027            JAXUCZ010000005.1  171757181-171758747 c
FEATURES             Location/Qualifiers
     source          1..2027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2027
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="ceramide-1-phosphate transfer protein"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
     exon            1..235
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..460
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    312..314
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="upstream in-frame stop codon"
     CDS             339..989
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="isoform a is encoded by transcript variant 1;
                     glycolipid transfer protein domain-containing protein 1;
                     glycolipid transfer protein domain containing 1"
                     /codon_start=1
                     /product="ceramide-1-phosphate transfer protein isoform a"
                     /protein_id="NP_001423826.1"
                     /db_xref="GeneID:313771"
                     /db_xref="RGD:1359656"
                     /translation="MDGPERDFNLKVVLISFKKCLTDKGEVLLDHYTASWKGLVRFLN
                     SLGAVFSFISKDVVSKLQIMEHLRSGPQSEHYISLQSMVAYEVSNKLVDRDSRSRPRH
                     PNSGCRTVLRLHRALHWLQLFLEGLRTSSEDARTSTLCSEAYNATLAAYHSWIVRQAV
                     NVAFHALPPRKVFLEAMNMGSSEQAVEMLGEALPFIEQVYDISQKLYAEHSLLDLP"
     misc_feature    417..863
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
     misc_feature    417..863
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="Glycolipid transfer protein (GLTP); Region: GLTP;
                     pfam08718"
                     /db_xref="CDD:462575"
     exon            461..2027
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccgcaggc tgcgagcttg ggggaaagca tagggatggg agctcttacc tgacagtgaa
       61 ctaggcagca gagccatgcc tctgtagacc accggaacgg agggcaaaga ttcgtcaccc
      121 acagcagcct aattatagct ttgatcaacc ccccccatca ctgaccttcc ctgcaccctt
      181 tgccctccgc gggagtaaag aaccaccact caccccccac cggaacccgt ctcagatctt
      241 cttcccaatc acttcctgag aaaatgaacc acagaatgag ctaattcagc atggcggcta
      301 caagttctgt gtgaaactat ttcagttcgt gttggaagat ggatggccca gagagagatt
      361 tcaaccttaa ggttgtcctg atcagcttca agaagtgtct cactgacaag ggagaggtgc
      421 tgctggacca ctatactgcc agctggaagg ggcttgtcag gtttctgaac agcctagggg
      481 ctgtcttttc attcatctcc aaggatgtgg tctcaaagct tcagattatg gagcatctga
      541 gaagtggccc acagtctgaa cactacatta gcttgcaatc catggtagcc tacgaggtga
      601 gcaacaagct ggtggacaga gacagccgct cacgtccccg acaccctaac tcaggctgcc
      661 ggactgtgct gcgcctacac cgtgctctgc attggctaca gctgttcctg gaaggcctgc
      721 gcaccagctc tgaggatgct cgtacctcca ccctctgcag tgaggcctac aatgccacac
      781 tggctgccta tcactcctgg atagtacgtc aagctgtcaa tgtggccttc catgccttgc
      841 ccccacgcaa ggtcttcctt gaggccatga atatggggtc ctctgagcaa gcagtggaga
      901 tgctgggaga ggccctgccc ttcattgagc aagtgtatga catctcccag aagctctatg
      961 ctgaacattc cctgctagac ctgccctagt agtggtaacc atactgtgtg gacttcccct
     1021 gctcagaact gggtttgggc aatctagggc tactcccaca gcagggcttt ctggaaacta
     1081 ctgtcacccc tgtaagctga actggtggaa agccagtctg tgaaaagaaa ggtcgtgggc
     1141 agctgaacca agaaaggtga atgctagtca tcctcttggt tcaggatgag acagttgaac
     1201 tccagttttg ccctccactt cagtcatgtg ttcagtcagg cttgattgaa gtgcagatgg
     1261 aaaatggaga agtggggggc ggtgtcatgt atctgcaaca acccaaggtt gctctacctc
     1321 tcctgtatag aatctgaaat ggtataagga cccaggaccc aggagctgtc ttccctacag
     1381 ccaacatgcc cagccaatgt gtatcctaca tgtctggggc cccttcatat tccaaaagct
     1441 gtaacatggg taacatgaag ttcctctggc agtggcatga gtccctgccc ttcacctgct
     1501 tccttgttag tctctctgca taccaaacag gcccttgcct ccttggaaat ggaaactgta
     1561 tgaaaccaat agctgaggct tctctaagaa agcctgccct ggtcagtgca gcctgttcca
     1621 cagcttctcc agtatagtac cgtcagcctt ctgaaggtgg cttcttacaa cacatgtacc
     1681 cccaggattc taagatgtca atactaactg gccaaaccat acctctctct agccagccct
     1741 gctgctcctg ttgccataat acgcagatga cttaggacat gacttgtggg aggagactag
     1801 gcccctttgt ctgacagatg gccataccta gcatggctaa tacccagtgt ataagaccat
     1861 aagctttccc actgggtctt aatgttaaac ccgaggacaa tgccctcagc gtagctgatg
     1921 tgtgcaaatg caaactttgg ggggcacatc tctttcctta agaattgtga tctatgtatt
     1981 tccaacataa ataaattaca cctacatgat tgggtatagc actctgg
//
LOCUS       NM_001437525            3107 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 24 (Zfp24), transcript
            variant 2, mRNA.
ACCESSION   NM_001437525 XM_006254464
VERSION     NM_001437525.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3107)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3107)
  AUTHORS   Howng,S.Y., Avila,R.L., Emery,B., Traka,M., Lin,W., Watkins,T.,
            Cook,S., Bronson,R., Davisson,M., Barres,B.A. and Popko,B.
  TITLE     ZFP191 is required by oligodendrocytes for CNS myelination
  JOURNAL   Genes Dev 24 (3), 301-311 (2010)
   PUBMED   20080941
REFERENCE   3  (bases 1 to 3107)
  AUTHORS   Wang,H., Sun,R., Liu,G., Yao,M., Fei,J. and Shen,H.
  TITLE     Characterization of the target DNA sequence for the DNA-binding
            domain of zinc finger protein 191
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 40 (8), 704-710 (2008)
   PUBMED   18685786
REFERENCE   4  (bases 1 to 3107)
  AUTHORS   Wu,Y., Yu,L., Bi,G., Luo,K., Zhou,G. and Zhao,S.
  TITLE     Identification and characterization of two novel human SCAN
            domain-containing zinc finger genes ZNF396 and ZNF397
  JOURNAL   Gene 310, 193-201 (2003)
   PUBMED   12801647
REFERENCE   5  (bases 1 to 3107)
  AUTHORS   Albanese,V., Biguet,N.F., Kiefer,H., Bayard,E., Mallet,J. and
            Meloni,R.
  TITLE     Quantitative effects on gene silencing by allelic variation at a
            tetranucleotide microsatellite
  JOURNAL   Hum Mol Genet 10 (17), 1785-1792 (2001)
   PUBMED   11532988
REFERENCE   6  (bases 1 to 3107)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254464.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.19498.1,
                                           SRR26643292.59012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000018.1  15581934-15582006   c
            74-573              JAXUCZ010000018.1  15578901-15579400   c
            574-721             JAXUCZ010000018.1  15578524-15578671   c
            722-3107            JAXUCZ010000018.1  15573031-15575416   c
FEATURES             Location/Qualifiers
     source          1..3107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3107
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zinc finger protein 24"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
     exon            1..73
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            74..573
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    103..105
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="upstream in-frame stop codon"
     CDS             154..1260
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="zfp-191; zinc finger protein 191"
                     /codon_start=1
                     /product="zinc finger protein 24"
                     /protein_id="NP_001424454.1"
                     /db_xref="GeneID:360204"
                     /db_xref="RGD:727963"
                     /translation="MSAQSVEEDSILIIPNPDEEEKILRVKLEEDPDGEEGSSISWNH
                     LPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVA
                     ILPRELQTLVREHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEEIASQED
                     AQGLPSSELDAVENQLKWASWELHSLRHCDDDATAENGALAPKQEIASAGESHEVPGT
                     LNIGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGE
                     KPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKP
                     YECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV"
     misc_feature    295..630
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    295..630
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    547..549
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    577..579
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    <898..1140
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <898..1140
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    904..1056
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNK3.1);
                     Region: Necessary and sufficient for nuclear localization.
                     /evidence=ECO:0000250"
     misc_feature    910..972
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    910..972
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(925..927,931..933,937..939,943..948,955..960,
                     967..969,1009..1011,1015..1017,1027..1032,1039..1044,
                     1051..1053,1093..1095,1099..1101,1105..1107,1111..1116,
                     1123..1128,1135..1137)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(925..927,931..933,937..939,943..948,955..960,
                     967..969,1009..1011,1015..1017,1027..1032,1039..1044,
                     1051..1053,1093..1095,1099..1101,1105..1107,1111..1116,
                     1123..1128,1135..1137)
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    973..975
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    994..1056
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    994..1056
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1027..1029
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1066..>1227
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1066..>1227
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1078..1140
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1078..1140
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1156..1158
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P17028; propagated from
                     UniProtKB/Swiss-Prot (Q7TNK3.1); phosphorylation site"
     misc_feature    1162..1224
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1162..1224
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            574..721
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
     exon            722..3107
                     /gene="Zfp24"
                     /gene_synonym="Zfp191; Znf24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggaagcg gctgaaagcg gcggcgcagc gtctgcccgg gacgacgagg ctgtggcggg
       61 tcccgagcca gaggagtact tttgaggaaa acagggtatt tctgaggtct gtaccttgcc
      121 tcagttgcct tttcttggag gtattgtaac aggatgtctg cccagtcagt ggaagaagat
      181 tcaatactta tcatcccaaa tccagatgaa gaagaaaaaa ttctgagagt gaaactagag
      241 gaggatcctg acggtgaaga aggatcgagc atttcctgga accatctccc tgacccggag
      301 attttccggc agcggttcag gcagtttgga taccaggatt caccaggacc gcgagaggcg
      361 gtgagccagc tccgagaact gtgccgcctg tggctcagac cggagacgca cacgaaggag
      421 cagatactgg agctggtggt tttggagcag tttgtcgcca tcctccccag ggagctacag
      481 actttggttc gagagcatca cccagagaac ggagaggagg cagtgactgt tctagaggac
      541 ttggagagtg aacttgatga ccctggacag ccggtttctc tccgtcggcg gaaacgggaa
      601 gtacttgtag aagagatagc atctcaagaa gacgctcagg gattaccgag ttctgagctt
      661 gacgccgtag agaaccagct caagtgggca tcctgggaac tccactctct gaggcactgt
      721 gatgatgatg ctacggcaga gaatggagcc ctggccccaa agcaggagat cgcttcagcg
      781 ggagagtctc acgaggttcc tggcactctc aacataggtg ttcctcagat tttcaaatat
      841 ggagaaacct gttttcccaa gggcaggttt gaaagaaaga gaaatccttc cagaaagaaa
      901 caacacatat gtgacgagtg tgggaaacac ttcagtcagg gctctgccct tattcttcat
      961 cagagaatcc acagcgggga gaagccttac ggatgtgtcg aatgtgggaa agccttcagc
     1021 agaagctcca tcctggtgca gcaccagaga gtccatactg gagaaaaacc ctacaagtgt
     1081 ctcgaatgtg ggaaagcctt tagccagaat tctgggctca ttaaccatca gcgaatccac
     1141 actggggaga aaccgtatga atgtgttcag tgtgggaaat cctatagtca aagctcaaat
     1201 ctttttagac atcagagaag acacaatgca gaaaaacttt taaatgttgt gaaggtttaa
     1261 gaaattatga ggaaacaatc agcactcagg tctttttctt cagaaatgaa gacaaaatta
     1321 aaaagtgaag agatatggaa actatttttc cccattgact gagaaaatct actgggaaat
     1381 aaaaaaaaaa aaatcttcat tcaccattat taccttgaaa gaaatggtgt tatacctgcc
     1441 tagaaaccga aattttaaat aattcaggtg ttaataacct aaattttcca tgtgatgttt
     1501 atattttctt tttttctccc caagtaatta gatgcctggt tctctgtccc tccccttttt
     1561 cagacagcta ctttatttct gtgttgatca ctggaggggt gttctgtgag ggtgcacacc
     1621 tttttgtttt aaagggcaac acaggaattg taaaatctaa agcccatctt caaggtttag
     1681 aaccatcctt gaaagcttag cttccttttg ttcaggttga gaagataacg gccaaagccg
     1741 cagtcagata agccttaagt ctcagacgag agatggcagc aaaacttcca ggagcggagg
     1801 gacaactggg gaagttccct ggtgaagcat gtctcttaag tacagtcagt ctacaggaaa
     1861 cctccaaagg aaaaagtgat tttacctaac ttgtgggaat cttactaact aaaatggttt
     1921 tcctgtgtaa acacagacaa ttgtagaagt gatggtaaat caaacactaa ggaagaatgt
     1981 agtgatattg aaaggcaaat gtaaaattaa agtaattata tgtatgacat ggcttttaga
     2041 aaaattctta actcattttg cctcatccta gttaaggaca gggaattccg tgatagggtg
     2101 ggcagcaata tcaggtttgc tatttttatt cctttggtac aaaagggttg aacaccaggc
     2161 taaaacagcc atacatttct tattaaacgt ttctactgac agtgcactgt gctgggtact
     2221 gtaatcctac ctaagcaggt aggtattcgc tccactgtaa gtcatgaggg gtttccccat
     2281 caccattccc agccacctct gagagcgcca gagctgtagt tctcttgcca gtgtgttgtg
     2341 tttggaggga gagctagctg gtcagctctt agcgttcttc agagctgagc tcaagacaca
     2401 ctcttagttt gaaagtttat gaatcttaaa aatccaaaca tttctagtag cattgtggtt
     2461 gtagctacac attgaatgga ctgtacttta aacaactaag ctattaatta ctagtttatt
     2521 aacggtcaga attgattttc taatctacag tcttaacaca tttttttaaa gaagtattaa
     2581 aagtaataca ttttagtagt aggattctgt atgccttggc taagaatcca agtactgtgg
     2641 ttctactgtt taatggaaaa ctctggaagt taaagcagtg ggtaagagaa gaggttttgt
     2701 ttggttttgt tttgttttgt atgtaagaca ggcattgtta catggaaaat tatccatgca
     2761 agtacaaata ttttatagct ccagttattt gggtcctatc tggtgcttcg tcaaatttta
     2821 acgtgaaaag tgaggttttt gagtgaacct ggtgaaaagc agtaaaaaat gcagcaccgc
     2881 tgctgaggtg aggcagaatg acgcttgttc atgattttct gagaacaatt ataagaaatg
     2941 tgctttatag atgaagattt attgaggtat aaatatgtag taatgctata atgtattttt
     3001 aagttataca agaaaatgta gggacttttg tttgggtctt tctctgtggc tgagaggaaa
     3061 caagttaatg tccaataaag ctggaaactc ctctgctcta agataaa
//
LOCUS       NM_001437242            5355 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus HR, lysine demethylase and nuclear receptor
            corepressor (Hr), transcript variant 1, mRNA.
ACCESSION   NM_001437242 XM_063274609
VERSION     NM_001437242.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5355)
  AUTHORS   Kuramoto,T., Kuwamura,M., Tagami,F., Mashimo,T., Nose,M. and
            Serikawa,T.
  TITLE     Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair
            loss and exhibit focal glomerulosclerosis
  JOURNAL   Exp Anim 60 (1), 57-63 (2011)
   PUBMED   21325752
REFERENCE   2  (bases 1 to 5355)
  AUTHORS   Hsieh,J.C., Slater,S.A., Whitfield,G.K., Dawson,J.L., Hsieh,G.,
            Sheedy,C., Haussler,C.A. and Haussler,M.R.
  TITLE     Analysis of hairless corepressor mutants to characterize molecular
            cooperation with the vitamin D receptor in promoting the mammalian
            hair cycle
  JOURNAL   J Cell Biochem 110 (3), 671-686 (2010)
   PUBMED   20512927
  REMARK    GeneRIF: Hr and VDR interact via multiple protein-protein
            interfaces, catalyzing histone demethylation to effect chromatin
            remodeling and repress the transcription of VDR target genes that
            control the hair cycle.
REFERENCE   3  (bases 1 to 5355)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   4  (bases 1 to 5355)
  AUTHORS   Hsieh,J.C., Sisk,J.M., Jurutka,P.W., Haussler,C.A., Slater,S.A.,
            Haussler,M.R. and Thompson,C.C.
  TITLE     Physical and functional interaction between the vitamin D receptor
            and hairless corepressor, two proteins required for hair cycling
  JOURNAL   J Biol Chem 278 (40), 38665-38674 (2003)
   PUBMED   12847098
REFERENCE   5  (bases 1 to 5355)
  AUTHORS   Fernandez,A., Silio,L., Noguera,J.L., Sanchez,A. and Ovilo,C.
  TITLE     Linkage mapping of the porcine hairless gene (HR) to chromosome 14
  JOURNAL   Anim Genet 34 (4), 317-318 (2003)
   PUBMED   12873232
REFERENCE   6  (bases 1 to 5355)
  AUTHORS   Potter,G.B., Zarach,J.M., Sisk,J.M. and Thompson,C.C.
  TITLE     The thyroid hormone-regulated corepressor hairless associates with
            histone deacetylases in neonatal rat brain
  JOURNAL   Mol Endocrinol 16 (11), 2547-2560 (2002)
   PUBMED   12403844
REFERENCE   7  (bases 1 to 5355)
  AUTHORS   Zlotogorski,A., Ahmad,W. and Christiano,A.M.
  TITLE     Congenital atrichia in five Arab Palestinian families resulting
            from a deletion mutation in the human hairless gene
  JOURNAL   Hum Genet 103 (4), 400-404 (1998)
   PUBMED   9856480
REFERENCE   8  (bases 1 to 5355)
  AUTHORS   Cichon,S., Anker,M., Vogt,I.R., Rohleder,H., Putzstuck,M.,
            Hillmer,A., Farooq,S.A., Al-Dhafri,K.S., Ahmad,M., Haque,S.,
            Rietschel,M., Propping,P., Kruse,R. and Nothen,M.M.
  TITLE     Cloning, genomic organization, alternative transcripts and
            mutational analysis of the gene responsible for autosomal recessive
            universal congenital alopecia
  JOURNAL   Hum Mol Genet 7 (11), 1671-1679 (1998)
   PUBMED   9736769
  REMARK    Erratum:[Hum Mol Genet 1998 Nov;7(12):1987-8]
REFERENCE   9  (bases 1 to 5355)
  AUTHORS   Thompson,C.C. and Bottcher,M.C.
  TITLE     The product of a thyroid hormone-responsive gene interacts with
            thyroid hormone receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8527-8532 (1997)
   PUBMED   9238010
REFERENCE   10 (bases 1 to 5355)
  AUTHORS   Thompson,C.C.
  TITLE     Thyroid hormone-responsive genes in developing cerebellum include a
            novel synaptotagmin and a hairless homolog
  JOURNAL   J Neurosci 16 (24), 7832-7840 (1996)
   PUBMED   8987811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063274609.1.
            
            Summary: This gene encodes a protein that is involved in hair
            growth. This protein functions as a transcriptional corepressor of
            multiple nuclear receptors, including thyroid hormone receptor, the
            retinoic acid receptor-related orphan receptors and the vitamin D
            receptors, and it interacts with histone deacetylases. The
            translation of this protein is modulated by a regulatory open
            reading frame (ORF) that exists upstream of the primary ORF.
            Mutations in this upstream ORF cause Marie Unna hereditary
            hypotrichosis (MUHH), an autosomal dominant form of genetic hair
            loss in human. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.57288.1,
                                           SRR26643295.51265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               JAXUCZ010000015.1  52038860-52039413
            555-1205            JAXUCZ010000015.1  52040641-52041291
            1206-1989           JAXUCZ010000015.1  52041944-52042727
            1990-2140           JAXUCZ010000015.1  52043839-52043989
            2141-2325           JAXUCZ010000015.1  52044075-52044259
            2326-2490           JAXUCZ010000015.1  52045901-52046065
            2491-2580           JAXUCZ010000015.1  52047412-52047501
            2581-2696           JAXUCZ010000015.1  52047650-52047765
            2697-2778           JAXUCZ010000015.1  52049011-52049092
            2779-2942           JAXUCZ010000015.1  52049725-52049888
            2943-3179           JAXUCZ010000015.1  52050003-52050239
            3180-3345           JAXUCZ010000015.1  52050443-52050608
            3346-3415           JAXUCZ010000015.1  52050813-52050882
            3416-3546           JAXUCZ010000015.1  52051160-52051290
            3547-3666           JAXUCZ010000015.1  52051432-52051551
            3667-3782           JAXUCZ010000015.1  52051646-52051761
            3783-3947           JAXUCZ010000015.1  52054044-52054208
            3948-4076           JAXUCZ010000015.1  52054444-52054572
            4077-5355           JAXUCZ010000015.1  52054733-52056011
FEATURES             Location/Qualifiers
     source          1..5355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..5355
                     /gene="Hr"
                     /note="HR, lysine demethylase and nuclear receptor
                     corepressor"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
     exon            1..554
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    405..407
                     /gene="Hr"
                     /note="upstream in-frame stop codon"
     exon            555..1205
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..4139
                     /gene="Hr"
                     /EC_number="1.14.11.65"
                     /note="protein hairless; hairless homolog; hairless
                     protein; hair growth associated; [histone
                     H3]-dimethyl-L-lysine(9) demethylase hairless"
                     /codon_start=1
                     /product="lysine-specific demethylase hairless"
                     /protein_id="NP_001424171.1"
                     /db_xref="GeneID:60563"
                     /db_xref="RGD:620634"
                     /translation="MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLHHGALCLG
                     EPVPFWRGVLSAPDSWLPPGFLQGPKDTLSVVEGEGSRNGERKANWLGSKEGLRWKEA
                     MLAHPLAFCGPACPPRYGPLIPEHSSGHPKSDPVAFRPLHCPFLLETKILERAPFWVP
                     TCLPPYLMSSLPPERSYDWPLAPSPWVYSGSQPKVPSAFSLGSKGFYHKDPNILRPAK
                     EPLAASESGMLGLAPGGHLQQACDAEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPR
                     TPWPSCPPGLVHTLGNVWAGPGSNSFGYQLGPPVTPRCPSPGPPTPPGGCCSSHLPAR
                     EGDPGPCRKCQDSPEGSSSGPGESSEERNKAGSRASPPSHHTKLKKTWLTRHSEQFEC
                     PGGCPGKGESPATGLRALKRAGSPEVQGARGPAPKRPSHTFPGTGRQGARAWQETPET
                     STGSKAEAQQQEEQRGPRDGRIRLRESRLEDTSCQHHLAGVTQCPSCVQAAGEVEILT
                     SHSQKSHRLPLEEKPLEEDSCATSEEGGGSSPEASINKGLAKHLLSGLGDRLCRLLRK
                     EREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIAG
                     AGKNREKTGSREQRTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRG
                     HCFCQVDARVWAPGDGGQQKEPTEKTPPAPQLSCNGDSNRTKDIKEETPDSTESPAED
                     RAGRSPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILDSIIAQV
                     VERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTRLSPPGALLWLQEPRPKHGFRLFQE
                     HWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTSLDSTAFWKGFS
                     HPEARPKLDEGSVLLLHRPLGDKDESRVENLASSLPLPEYCAHQGKLNLASYLPLGLT
                     LHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSGL
                     DGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDSGLRR
                     RLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLCH
                     QGASLPPDHRMLYAQMDRAVFQAVKVAVGTLQEAK"
     misc_feature    1524..1727
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1830..2009
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2118..2222
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2271..2285
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: LXXLL motif 1"
     misc_feature    2679..2828
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2847..2861
                     /gene="Hr"
                     /note="propagated from UniProtKB/Swiss-Prot (P97609.2);
                     Region: LXXLL motif 2"
     misc_feature    <3834..3989
                     /gene="Hr"
                     /note="RmlC-like cupin superfamily; Region:
                     cupin_RmlC-like; cl40423"
                     /db_xref="CDD:477354"
     misc_feature    <3834..3989
                     /gene="Hr"
                     /note="RmlC-like cupin superfamily; Region:
                     cupin_RmlC-like; cl40423"
                     /db_xref="CDD:477354"
     exon            1206..1989
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2140
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2325
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2490
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2580
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2696
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2778
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2942
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3179
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3345
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3415
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3546
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3666
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3782
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3947
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4076
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..5355
                     /gene="Hr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgcgcgt ctggcgatgg cgatcagagg tcctgctgcg ctctccgctg cgctctccct
       61 ccattagccg cgctacgcgg tgctgcgccc tcgctggtgc ctcgctcctg gctcacagga
      121 tcggcccccc acttccaggc acgaccccct tccccggccc ctcggccttt ccccccactc
      181 agccatctcc gacccggggc gcgcgttccc cccggcccgg cttcttctct ccctccgggg
      241 acacccgctc cctagccccg gttcgaccct ccccaaagcg cagcacggag tctcggcgtc
      301 ccatggcgca acctacagcc tcggcccaga agctggtgcg gcccatccgc gccgtgtgcc
      361 gcatcctgca aatcccggag tccgacccct ccaacctgcg gccctagagc gcccccgacg
      421 cccgggggga aagagagcgc gagcgcgctg agcagaaagc gggagaacgc cccgaagccg
      481 gcccatgggg agcgagtgcc cagcaccggc ttgcacgacc gccgcccaca ccgcgcccgg
      541 cctgtgaagc ccaggacccc cccctgggag agccccatga gggtaggaga gtgatggaga
      601 gtatgcccag cttcctgaag gacaccccag cctgggagaa gactgcccct gtgaacggca
      661 ttgtgggaca ggagcctggt acctccccgc aggatggctt gcaccatggg gcactgtgcc
      721 taggagaacc tgttcccttt tggaggggtg ttctgagcgc cccagactcc tggctccctc
      781 ctggcttcct ccaaggcccc aaggacacac tctcagtggt ggagggtgag ggttctcgga
      841 atggggagag gaaagccaac tggctgggta gcaaggaggg actacgctgg aaggaagcga
      901 tgctggccca tccactggcc ttctgtgggc cagcatgccc acctcgctat ggccccctga
      961 tacctgagca tagcagtggc catcccaaga gtgaccctgt ggccttccgg cccttgcact
     1021 gccctttcct gctggagacc aagattctag agcgagctcc cttctgggtt cctacctgct
     1081 tgcctcccta cctgatgtcc agcctgcctc cagagcgttc gtatgactgg cctttggccc
     1141 caagcccctg ggtatactct gggagccagc caaaagtgcc ctctgccttc agcttaggca
     1201 gcaagggctt ttaccacaag gatccaaaca tcctcaggcc agcaaaggag cccttggcag
     1261 cgtcagagtc tgggatgttg ggcttagctc ctggagggca tctccagcaa gcctgcgatg
     1321 cagaaggccc ctcgcttcac cagagggatg gggagacagg agctggcagg cagcagaatc
     1381 tttgcccagt tttcttgggg tacccagaca ctgttcctcg aaccccctgg ccttcttgtc
     1441 ccccaggcct ggttcacact ctcggtaacg tttgggctgg gccaggaagt aacagctttg
     1501 ggtaccagct aggcccacca gtcacaccaa ggtgcccatc acctgggcct cccacccctc
     1561 cagggggctg ttgctcatcc catctgcctg ccagagaggg tgatcctggc ccttgtagga
     1621 aatgtcagga tagcccagag ggaagtagca gtgggccagg ggaatccagt gaagaaagaa
     1681 acaaggctgg ctccagggcc tctcctccaa gccatcacac caagctgaaa aagacctggc
     1741 tcacacgcca ctcggaacag ttcgagtgcc caggtggctg tcctgggaag ggagagagcc
     1801 cagccactgg gctccgggca ctcaagaggg caggcagtcc agaggtccag ggagcaaggg
     1861 gcccggctcc caaacgccca tcccacactt tcccaggtac tgggaggcag ggggccaggg
     1921 cttggcagga gacaccagag acatccacag gaagcaaggc agaggcacag caacaagagg
     1981 agcaaagagg gccccgagat ggcaggattc ggctccggga atccagactt gaggatacat
     2041 cctgccagca tcacttagca ggtgtcactc agtgcccaag ctgtgtccag gcagctggag
     2101 aggtggagat actgaccagc cactcccaga aatcacatag gttacccctg gaagagaagc
     2161 cgttggagga ggattcctgt gccacttctg aggaaggagg agggtctagc ccagaagctt
     2221 ccatcaacaa gggcctagcc aagcatctac tgagtggtct gggtgaccga ctctgccgcc
     2281 tgctgcggaa ggagcgggaa gccctcgcct gggcacagcg tgaaggccag gggccagcca
     2341 tgacagagga cagcccaggc attccacact gctgcagccg ttgccaccac ggactcttca
     2401 acacccactg gagatgttcc cactgtagcc accggctgtg tgtagcctgt ggtcgcatag
     2461 ccggagctgg gaagaacagg gagaaaacag gctctcggga gcagcgcaca gatgactgtg
     2521 cccaggaggc tgggcatgct gcctgttccc tgattctgac ccagtttgtc tccagccagg
     2581 cgctggcaga actgagcact gtgatgcacc aagtctgggc caagtttgac attcgggggc
     2641 actgtttctg tcaagtcgat gcccgtgtgt gggcccccgg ggatgggggt cagcagaagg
     2701 aaccaacaga gaaaactccc ccagctccac aactttcctg caatggagat tccaatcgga
     2761 ccaaggacat caaagaagag accccagact ccacagagag cccagcagag gaccgtgctg
     2821 gccggtcacc acttccttgt ccctctcttt gtgagctgct agcctctaca gctgtcaaac
     2881 tctgcctggg gcatgagcgg attcacatgg cctttgcccc ggtcaccccg gctctgccca
     2941 gtgatgaccg cattaccaac atcctggaca gcattattgc gcaggtagta gaacggaaga
     3001 tccaagagaa agccctgggg ccaggccttc gagcagggtc aggcttacga aagggcctca
     3061 gcctgcccct gtcaccagtg cgaacccggt tgtctcctcc tggagctctg ctgtggctgc
     3121 aagagcccag gcctaagcac ggctttcgtc tcttccagga gcactggcgg cagggccagc
     3181 ctgtgttagt atcaggcatc cagaagacat tgagacttag cctgtgggga atggaagccc
     3241 ttgggacact tggtggccag gtgcagacac tgactgccct tgggccgccc caacccacca
     3301 gcctggacag cacagcattc tggaagggat tctctcatcc tgaggcacgt ccaaagttag
     3361 atgagggctc tgtcctcctg ctacaccgac ccctggggga taaggacgag agcagggtgg
     3421 agaaccttgc ctccagcctt ccactcccag agtactgtgc ccaccaaggg aaactcaacc
     3481 tagcgtccta cctccccctg ggtctcacac tgcatccact ggagccccag ctctgggcag
     3541 cctatggtgt gaactcgcac cgtggacacc tggggaccaa gaacctatgt gtggaggtgt
     3601 ctgacctaat cagtatcctg gtgcatgctg aggcacagct gcctccctgg taccgagcac
     3661 agaaagattt tctctcaggc ctggatgggg aagggctctg gtctccaggt agccagacca
     3721 gcactgtgtg gcatgtgttc cgagcccagg atgcccagcg tatccgtcgc tttctccaga
     3781 tggtgtgccc agctggagca ggaaccttgg agcctggtgc cccaggcagc tgctacttgg
     3841 attcagggtt gcgacgcagg ttaagggagg agtggggtgt gagctgctgg acactgctgc
     3901 aggctcctgg agaagcggtg ctggtgcctg ctggggcacc ccatcaggta cagggcttgg
     3961 tgagcacaat cagtgtcact cagcactttc tgtctcctga gacctcggcc ctctctgctc
     4021 agctctgcca ccagggagcc agcctgcccc ctgaccatcg tatgctttat gcccagatgg
     4081 accgggctgt gttccaagca gtgaaggtgg cggtggggac attacaggaa gctaaatagg
     4141 ggaccctggt gcctggaggg ggcgggggtg gagcaggtaa ctgagtgttc agtctgcatg
     4201 atttcagcgg ggaatggtac tgtggaactt aggtggtgtg atccgttcta caaatatctc
     4261 tttgggtaca agcagggaac cctgttccct caccctggcc ctggctctaa agggaacaac
     4321 tgtagtgctt acagccgctc ccctctccac ggtatcaggt tcaccctagg ggtccatgac
     4381 tccttctaag ccccactcca ggggataagt acccttcctt ggggaagctt gggaattgtt
     4441 ttagtttaag caacacttcc tctggctgct tcaccctgtg ttctccctgg catccccacg
     4501 cccacccctg gctgtgctac agctcaccag catccacaca aagttccgac tgtaggtgtg
     4561 ctggaccggg agccacagaa ttcttccctt actgtggagt tggggaggag aggacctcag
     4621 ttaatgggcc atactggctg gagggaacac catgggcaga accactgggt cccccgcttc
     4681 tgcctctctc cttccctgtc actgttaaaa ttggttgttc agtgactgct gccagcatag
     4741 ttggcctcac tctgctggcc acgtgggcta gggggaaaag gcaaacacag aaatctgatc
     4801 tggagcagaa gccagtggac agggtgagaa gggactgggg gacctggtga cagagacctc
     4861 acataccact gccagatctt tgggagcccc cctggagctt tctggggact gaagatgttc
     4921 ctgacttaca gagggaaggc agagttctaa ggacagcact gagatagcct ccctgggtgg
     4981 catcaacctg tggagattac agaaccccct gcctctgtcc cacctgtcct gtgcgttctg
     5041 acttggagag acatccagga tagccctggc tcaacccaac tactcttggt gtccaagcca
     5101 ccaggacaga gcttcactgc ctcaaacagc tgacccctac cctcatggcc cttctggtgc
     5161 caacagctga cccctaccct catggccctt ctagtgccag cagctgaccc catccccacg
     5221 gccctctggt actgccttgt ctcctacctc ttccttgtgt atctcaaccg cacacatgcg
     5281 ccagctcttg ttatacttaa cagttcctgc tgtggtttgg ggattttttt ttaattaaat
     5341 aaaagttttt attat
//
LOCUS       NM_001437317            4659 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), transcript
            variant 4, mRNA.
ACCESSION   NM_001437317 XM_039089367
VERSION     NM_001437317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039089367.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.47098.1,
                                           SRR26643287.27739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000012.1  16568376-16568531
            157-292             JAXUCZ010000012.1  16579863-16579998
            293-423             JAXUCZ010000012.1  16584164-16584294
            424-1062            JAXUCZ010000012.1  16586628-16587266
            1063-1139           JAXUCZ010000012.1  16588652-16588728
            1140-1242           JAXUCZ010000012.1  16591172-16591274
            1243-1407           JAXUCZ010000012.1  16592806-16592970
            1408-1522           JAXUCZ010000012.1  16597507-16597621
            1523-1662           JAXUCZ010000012.1  16598234-16598373
            1663-1713           JAXUCZ010000012.1  16602723-16602773
            1714-1851           JAXUCZ010000012.1  16604251-16604388
            1852-2000           JAXUCZ010000012.1  16609121-16609269
            2001-2079           JAXUCZ010000012.1  16609681-16609759
            2080-2177           JAXUCZ010000012.1  16658476-16658573
            2178-2400           JAXUCZ010000012.1  16670103-16670325
            2401-2470           JAXUCZ010000012.1  16687074-16687143
            2471-4659           JAXUCZ010000012.1  16687679-16689867
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4659
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..156
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            157..292
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="upstream in-frame stop codon"
     CDS             226..2787
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 4; E3
                     ubiquitin-protein ligase RNF216"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216 isoform 2"
                     /protein_id="NP_001424246.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTEDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTV
                     SPRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEY
                     WLDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPG
                     PASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLV
                     KETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLAS
                     QDDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAIT
                     RKAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRH
                     CRSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYG
                     EFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLP
                     QTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKC
                     QGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCR
                     CGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAE
                     EEQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPP
                     VRPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     misc_feature    1726..1896
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1726..1896
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 216 (RNF216) and similar proteins; Region:
                     RING-HC_RBR_RNF216; cd16630"
                     /db_xref="CDD:438292"
     misc_feature    1993..2148
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    1993..2148
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="BRcat domain found in RING finger protein 216
                     (RNF216); Region: BRcat_RBR_RNF216; cd20339"
                     /db_xref="CDD:439000"
     misc_feature    2179..2349
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     misc_feature    2179..2349
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="Rcat domain found in RING finger protein 216
                     (RNF216); Region: Rcat_RBR_RNF216; cd20353"
                     /db_xref="CDD:439014"
     exon            293..423
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1062
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1139
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1242
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1407
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1522
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1662
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1713
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1851
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2000
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2079
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2177
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2400
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2470
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..4659
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagcggcc tcggcggcag cggcggcggc gacgacagca ttggcagtgg cggctgtagc
       61 agcggggaag cttttcgagc ggatgcttca ggtgacttga gattgaactc ccgggcgtcg
      121 agccccgctc gcggagctgg actagctgcg tggcgaaccc tacagaacag atgatcacca
      181 tgtctgggtt ctagcaatca catacgttta tatctgaatt tgaaaatggc agagggaaac
      241 aaccaagagg aggtcattca cttgaacaac tttcactgcc accgggggaa ggagtggatg
      301 gctgtcagag aggggcccat caccatatct gactcctctg atgaggaagg gattccaatg
      361 ctggttaccc cggctactga gcaacaggaa gacgacctgg atgatgatgt catcctgaca
      421 gaagatgatt ctgaggatga atgtggtgga tttctggatc ttaagactga gaaaaaagga
      481 ggagaagcca aacctggacc aagcaataag cagacagcag acaatactgt cagccccagg
      541 ctggagcaga aagtcattat tttgggagaa aatggtcttc ttttttcaga aagtgagcct
      601 ctggaagttc agaaccaatt atctgaagac tcagagacag atcttttatc aaatcctggt
      661 gagccagctg cctcagtaga tgagcagcta attgaagaag agtactggct tgaccatccc
      721 tacttccagg ctctgaatcc acagcctcag gagagaacaa accagcttgt gccccaagag
      781 cgacattctg aatcagaaat gggcccaatg tttttccgcc atgatttccc ggagccagct
      841 tttccaaggc cagaacccca gcaggagggg attccaggac ccgcttctcc acaaccagcc
      901 catcctctag gagagcttga agaccagcaa ttagcaattg atgaagaccc tgggcctgcc
      961 taccccctgc caggacccca ggaggccaat ttggcaaatg tgtggggaca agaagctgct
     1021 gaaggggatc aagagctcat tccactgtta gtgaaagaaa cggaagcaag atttccagac
     1081 gtagcaaatg gatatgttga agagataatt catttgaaaa attactatga tttgaatgta
     1141 ctttgtaatt ttctcctgga aaatccagat tatccaaaga gagaagaccg aatccttatc
     1201 caccccagca gtagcctgct tgccagccag gatgatgtga agttgcctaa gatagacttt
     1261 tttgactatt ccaaattgac tccacttgac cagcgctgct tcatccaagc tgctgacctc
     1321 ttgatggctg atttcaagat gctcagcagc caggacatca agtgggccct gcacgagctc
     1381 aaagggcatt acgcaatcac ccgaaaggcc ttttctgatg ccattaaaaa atggcaggag
     1441 ctatcacctg aaaccagtgg aaagcggaaa aagaggaaag aaatgaatca gtattctttc
     1501 atagacttca aatttgaaca aggtaacata aaaatagaaa agaggatgtt ctttctggaa
     1561 aacaagcgtc gacactgtag gtcctatgac cagcaggccc tccttccagc tgtgcagcaa
     1621 gagcaggagt tctatgagca gaaaattaaa gagatggcag agcacgaaga ttttttgctt
     1681 gccctgcaga tgaatgaaga gcagtatcaa aaggatggcc agctgattga atgccgctgc
     1741 tgctatgggg agtttccatt tgaggagctg acacaatgcg ctgatgctca cttgttctgc
     1801 aaagaatgtc tcatcagata tgcccaagag gccgtgtttg gatctggaaa gtcagagctc
     1861 agctgcatgg aaggcagctg cacatgttcc ttcccaacca gtgaactgga gaaagtgctc
     1921 ccccagacca ttctgtacaa atactatgaa cggaaagctg aagaggaagt cgcagcagcc
     1981 tatgctgacg agcttgtccg gtgcccctct tgcagcttcc ctgctctgtt ggacagcgat
     2041 gtgaagaggt tcagctgccc taaccctcgc tgccgaaagg agacctgtag gaagtgtcag
     2101 ggactctgga aagaacacaa tggcctcacc tgtgaagagc tggcagaaaa ggatgacatc
     2161 aagtaccgga catctattga agaaaaaatg actgctgctc gaattagaaa atgccacaag
     2221 tgtgggactg gcctcatcaa atctgaaggc tgcaaccgca tgtcttgccg ctgtggtgcc
     2281 cagatgtgct acctctgtcg agtttctatc aatggctatg accacttctg ccagcatcct
     2341 cgctctccag gagccccttg ccaggaatgt tccaggtgct ccctctggac cgaccccact
     2401 gaagatgatg agaagctgat tgaggagatc caaaaggagg ctgaggagga gcagaaaaga
     2461 aagaatggag agaacacttt caaacgcatc gggcccccac tggagaagcc ggctgagaaa
     2521 gtgcagcgtg tggaagccct gccacggcct gtcccacaga acctgcaccc tcagatgcca
     2581 ccctatgcct ttgtccaccc acccttcccc ctgccacctg tgcggcccgt gttcaacaac
     2641 ttccccatca acatgggtcc tgtgcccgca ccctatgtac cccctctgcc caacgtgcgt
     2701 gtcaacttcg actttggcca cgtgcatgtg cccctggagc acaacctgcc catgcacttt
     2761 ggcccccaac cacggcatcg cttctgacac ccaaagccct gtccagctgt gctgagtctg
     2821 caggaggacc cagtctcatc ctctgagtag ggatgaagtc ctcgactccc tatggggtgt
     2881 gggctcgtgt cctcctgctc ttcccgttgc gaggtccact gctccttcgg gtctgatgcg
     2941 ccttgggtgc tgactgtcgc tgcaccagta atagggcagc tccccgggtc tgccatctat
     3001 cttagcagcc agtccagggg ccttggccga gaagcaggcc ctttaagcat ttgccatact
     3061 tcctccccag cagaccactg aaagcccaag ggaaaatggc ctaccctccc caggccaggg
     3121 ctctctcctt gttgcccaag gcccactcag gtccaagggc cgccaagaat cttctgtggc
     3181 gcaagttttg ttctgttgtt acctagaggt tgctcctatt cacatagttt gagctgaagt
     3241 tttttgtgtg tccccatccg tggaaagtca ggttgaaggt atttccccag ggctggcaac
     3301 tgctgagaac cagtagtcct gacacttgac atcaaacaga aggacccttt tagggccctt
     3361 tattcctggg ctgccccttt tctgggagag acctcacttg tcaccaacct gggatgagca
     3421 gcatctctcc taaggttttt aggggcttcc ctagcagtgc agatgacctc atggagctgc
     3481 tgcagctatc acagcaaccc tcctgcccgc tcagctgtcc ctcactagtt agcagtggat
     3541 gcagacagga gaggtctagc tccaagatga ggacagctgg cttccctaga gtcagatgaa
     3601 aatcggcctg cacagtcttt gccatgttcc cactacctgt gtcccctcct gtccagacca
     3661 gatctttata ctctcctcca gtgtgtgttg accagggctg atagcaagtg tctcactcag
     3721 ttgtactggc tgtccttgtc gtggagtgtc ccatgttcag agtgtacaga cttagaagag
     3781 agaagatgtc cctgggaaaa ggaaagactc cctgaggtgc ccactgtcac tggagtgtgg
     3841 gtagggcaca cagggcaact caggagccct gccatgggtc acctgaactg tgatgctagt
     3901 ctgaatgaca gtgccttgga aagatgggcc acatgctgca tgacaggatc ctccaagtac
     3961 cttaacaatt agtgtactcg tgttctctgc acttctccag aagccctgca gggggcggta
     4021 ctccgagcac tgcccctcca aggcctcatg agccgctgga ctgggcaccc agttctgggc
     4081 gcctcagtac cctatcacat tgttccacca agaggccaga tggaaaaact ggcagtttct
     4141 ggggtagctg gaagagcagg ccaggcaggt gccatccaga ccctggcact ccatttggag
     4201 aggtgaggcc agagacgtat ccttcaaaat attgtcagtc tgtgacaggg agactgctac
     4261 tgcctgtctc catcaaggag tgaccctccc atgttgccag cagggctagg gagtgagggg
     4321 tgggccagca aggatcccca aggcagctgc caccttaacc cctaggaccc agactgcttc
     4381 ctggtttaag aaactgccta gccactccca gtgtatttgc cttaaaactg gagagaatct
     4441 agtatttgca cttagcaaaa gatttcaaag ttaagagaaa agtgcatgat ctcactttgt
     4501 acaaaagaaa aaaaggaaaa aaaatgaagt agatggttaa acgtttttct ttaccttttg
     4561 gtagtaaaaa tagagaaaac aagtctgttt aaactactgt gtaaaaagac tgtatcatat
     4621 gtaacttgaa ttttgtgtaa ataaatgttt gtgaacgct
//
LOCUS       NM_001436946            3795 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus AE binding protein 1 (Aebp1), transcript variant
            2, mRNA.
ACCESSION   NM_001436946 XM_006251316
VERSION     NM_001436946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3795)
  AUTHORS   Blackburn,P.R., Xu,Z., Tumelty,K.E., Zhao,R.W., Monis,W.J.,
            Harris,K.G., Gass,J.M., Cousin,M.A., Boczek,N.J., Mitkov,M.V.,
            Cappel,M.A., Francomano,C.A., Parisi,J.E., Klee,E.W., Faqeih,E.,
            Alkuraya,F.S., Layne,M.D., McDonnell,N.B. and Atwal,P.S.
  TITLE     Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly
            and Connective Tissue Structure Resulting in a Variant of
            Ehlers-Danlos Syndrome
  JOURNAL   Am J Hum Genet 102 (4), 696-705 (2018)
   PUBMED   29606302
REFERENCE   2  (bases 1 to 3795)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3795)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3795)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 3795)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 3795)
  AUTHORS   Lyons,P.J., Muise,A.M. and Ro,H.S.
  TITLE     MAPK modulates the DNA binding of adipocyte enhancer-binding
            protein 1
  JOURNAL   Biochemistry 44 (3), 926-931 (2005)
   PUBMED   15654748
REFERENCE   7  (bases 1 to 3795)
  AUTHORS   He,G.P., Muise,A., Li,A.W. and Ro,H.S.
  TITLE     A eukaryotic transcriptional repressor with carboxypeptidase
            activity
  JOURNAL   Nature 378 (6552), 92-96 (1995)
   PUBMED   7477299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 24, 2025 this sequence version replaced XM_006251316.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1444748.1,
                                           SRR26360186.1986541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               JAXUCZ010000014.1  84952849-84953291
            444-782             JAXUCZ010000014.1  84954813-84955151
            783-854             JAXUCZ010000014.1  84955673-84955744
            855-926             JAXUCZ010000014.1  84955866-84955937
            927-1037            JAXUCZ010000014.1  84956044-84956154
            1038-1106           JAXUCZ010000014.1  84956229-84956297
            1107-1184           JAXUCZ010000014.1  84957278-84957355
            1185-1265           JAXUCZ010000014.1  84957676-84957756
            1266-1319           JAXUCZ010000014.1  84957841-84957894
            1320-1429           JAXUCZ010000014.1  84958491-84958600
            1430-1569           JAXUCZ010000014.1  84958674-84958813
            1570-1654           JAXUCZ010000014.1  84959126-84959210
            1655-1799           JAXUCZ010000014.1  84959304-84959448
            1800-1885           JAXUCZ010000014.1  84959545-84959630
            1886-2009           JAXUCZ010000014.1  84959858-84959981
            2010-2206           JAXUCZ010000014.1  84960193-84960389
            2207-2386           JAXUCZ010000014.1  84960472-84960651
            2387-2738           JAXUCZ010000014.1  84960852-84961203
            2739-2878           JAXUCZ010000014.1  84961286-84961425
            2879-2978           JAXUCZ010000014.1  84961523-84961622
            2979-3795           JAXUCZ010000014.1  84962024-84962840
FEATURES             Location/Qualifiers
     source          1..3795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3795
                     /gene="Aebp1"
                     /note="AE binding protein 1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
     exon            1..443
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Aebp1"
                     /note="upstream in-frame stop codon"
     CDS             197..3580
                     /gene="Aebp1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; adipocyte enhancer-binding protein 1; aortic
                     carboxypeptidase-like protein"
                     /codon_start=1
                     /product="adipocyte enhancer-binding protein 1 isoform 2
                     precursor"
                     /protein_id="NP_001423875.1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
                     /translation="MAAVRTASLLCGLLALLALCPEGSPQTVLTDDEIQEFLEGFLSE
                     FETQSPPREDDVEAQPLPEPTQRARKSKAGGKPRADAEAPPEKNKDKEKKGKKDKGPK
                     AAKHLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKR
                     PSAGKRFSTVAPLETPERSLTSPSNPGTRELPEERGRTSLNTWQGQGEETQVEARQHR
                     PEPEEETEMPTLDYNDQIEREDYEDFEYIRRQKQPRPTPSRKRIWPEPPEEKTQEPEE
                     RKEVDPPLKPLLPPDYGDGYLIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEELKKPKK
                     EGSSPKEDTEDKWAAEKNKDHKGPRKGEELEEEWGPVEKIKCPPIGMESHRIEDNQIR
                     ASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVIT
                     QGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVA
                     RFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMK
                     VVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGMHGNEVLGRE
                     LLLLLMQYLCHEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLW
                     TEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIS
                     WMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAALAAARGEDEDEVSEAQETP
                     DHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLH
                     TNCLELSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANA
                     TISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFI
                     LARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRLQQRRLRYRLRMREQMRLRRLN
                     STTGPATSPTPALTLPPSPTPGSTSRLWEILPTTAAGWEESETETYTEVVTEFETEYG
                     PDLEVEELEEEEEEEEEMDTGLTFPVTTVETYTVNFGDF"
     sig_peptide     197..271
                     /gene="Aebp1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    1325..1786
                     /gene="Aebp1"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    1325..1786
                     /gene="Aebp1"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; Region: FA58C;
                     cd00057"
                     /db_xref="CDD:238014"
     misc_feature    1337..1834
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Required for DNA-binding and interaction with
                     NFKBIA. /evidence=ECO:0000250"
     misc_feature    1430..2041
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
     misc_feature    order(1469..1471,1553..1555,1574..1576)
                     /gene="Aebp1"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
     misc_feature    order(1469..1471,1553..1555,1574..1576)
                     /gene="Aebp1"
                     /note="sugar binding site [chemical binding]; other site"
                     /db_xref="CDD:238014"
     misc_feature    1751..1753
                     /gene="Aebp1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A2RUV9.1); glycosylation site"
     misc_feature    1832..3124
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with PTEN. /evidence=ECO:0000250"
     misc_feature    1859..2878
                     /gene="Aebp1"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; Region: Peptidase_M14_like; cl11393"
                     /db_xref="CDD:472171"
     misc_feature    1859..2878
                     /gene="Aebp1"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; Region: Peptidase_M14_like; cl11393"
                     /db_xref="CDD:472171"
     misc_feature    order(2042..2044,2051..2053,2237..2239,2264..2269,
                     2456..2461,2477..2479,2789..2791)
                     /gene="Aebp1"
                     /note="active site"
                     /db_xref="CDD:349427"
     misc_feature    order(2042..2044,2051..2053,2237..2239,2264..2269,
                     2456..2461,2477..2479,2789..2791)
                     /gene="Aebp1"
                     /note="active site"
                     /db_xref="CDD:349427"
     misc_feature    2888..3115
                     /gene="Aebp1"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; Region: Peptidase_M14NE-CP-C_like;
                     cd11308"
                     /db_xref="CDD:200604"
     misc_feature    2888..3115
                     /gene="Aebp1"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; Region: Peptidase_M14NE-CP-C_like;
                     cd11308"
                     /db_xref="CDD:200604"
     misc_feature    2990..3577
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Required for transcriptional repression.
                     /evidence=ECO:0000250"
     misc_feature    3185..3577
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
     misc_feature    3272..3361
                     /gene="Aebp1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            444..782
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..854
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..926
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1037
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1106
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1184
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1265
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1319
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1429
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1569
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1654
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1799
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1885
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2009
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2206
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2386
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2738
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2878
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2978
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3795
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccggag ctgggctcgc cagaacctct ctcggaatcc ccttgaatct ctctccccca
       61 cccctttctg gataccctcg acgtccacgt tgctccccag ggttcctcac gccctttccc
      121 gcccccacgc ggggcgccgc ccctgccacc caagtccctg ctcaagccca cccgactccc
      181 acgcgtgccc agagccatgg ctgcggtacg caccgcatcc ctgctctgcg gcctcttggc
      241 actcctggcg ctgtgcccgg aggggagccc acagacggtg ctgacggacg acgagatcca
      301 ggagttcctc gaaggcttcc tttcggagtt tgagacccag tccccgcccc gggaggacga
      361 cgtggaagcc cagccacttc ccgaacccac ccagcgtgcc cgcaaatcca aggcaggggg
      421 caagccgcgg gcagatgcag aagcccctcc agaaaagaac aaagacaaag agaagaaagg
      481 aaagaaggac aaaggcccca aggctgcaaa acacctggaa ggttccacca ggcccaccaa
      541 gaaaccaaag gagaagccac ccaaggccac caagaagccc aaagagaagc cacccaaggc
      601 caccaagaag cctaaagaga agccacccaa ggccaccaag aagcccaagg agaagccacc
      661 caaggccact aagaggccct cggcaggaaa gagattctca actgtagccc ccttagaaac
      721 gccggagcgt tcactcacct caccctccaa ccccggcacc agggagctac cagaggagag
      781 aggaagaacc tccctgaata cctggcaggg ccaaggagaa gagacccaag tggaggccag
      841 gcagcaccgg ccagagccag aggaggagac cgagatgccc acactggact acaatgacca
      901 gatagagcgg gaagattatg aagactttga gtacatcagg cgccagaagc agcccagacc
      961 cacacccagc aggaagagga tctggccaga gccccctgag gagaagaccc aagagccgga
     1021 ggaaaggaag gaagttgatc cgcctctgaa gcccctgttg ccccctgact atggggatgg
     1081 ctacttgatc cccaactacg atgacttgga ctactacttc ccccaccccc caccacagaa
     1141 gcccgatgtt ggacaagagg tggatgaaga aaaggaggag ttgaagaagc ccaaaaagga
     1201 gggcagtagc cccaaggagg acacagaaga caagtgggcg gcagagaaaa acaaggacca
     1261 caaaggaccc cggaagggcg aggagctgga ggaggagtgg ggtccagtgg agaaaatcaa
     1321 gtgcccacct atcgggatgg agtcacaccg cattgaggac aaccagatcc gcgcctcctc
     1381 catgctgcgc catggcctcg gagcccagcg gggccggctc aacatgcagg ctggtgccaa
     1441 tgaagatgac tactatgatg gggcatggtg tgctgaggac gagtctcaga cccagtggat
     1501 tgaggtggac acccggagga cgactcggtt cacaggcgtg attacacagg gtcgggactc
     1561 cagcatccat gacgactttg tgactacctt cttcgtgggc ttcagcaatg acagccagac
     1621 ctgggtgatg tacaccaatg gctatgagga aatgaccttc catgggaatg tggataagga
     1681 cacacctgtg ctgagtgaac tccccgagcc agttgtggcc cgtttcatcc gcatctatcc
     1741 actcacctgg aacggtagcc tgtgcatgcg cctggaggtg ctaggctgcc ctgtgacccc
     1801 tgtctacagc tactacgcac agaacgaggt ggtgaccact gacagcctgg acttccggca
     1861 ccacagctac aaggacatgc gccagctgat gaaggttgtg aatgaggagt gtcctaccat
     1921 tacccgcacg tacagcttgg gcaagagttc acgagggctc aagatctatg cgatggagat
     1981 ctcagacaac cccggggagc atgagctggg ggagcctgag ttccgctaca cagccggcat
     2041 gcacggcaat gaggtgctgg gccgagagct gctgttactg ctcatgcagt acctgtgtca
     2101 cgagtaccgg gatgggaacc ccagagtgcg taacctggtg caggacacgc gcatccacct
     2161 ggtgccttcg ctgaaccctg acggctacga ggtggcagcg cagatgggct cagagtttgg
     2221 gaactgggca ctggggctgt ggactgagga gggctttgac atcttcgagg atttcccaga
     2281 tctcaactct gtgctctggg cagctgagga gaagaaatgg gtcccctaca gggtcccgaa
     2341 caataacttg ccaatccctg aacgttacct gtccccagat gccacggtat ccacagaagt
     2401 ccgggccatc atttcctgga tggagaagaa cccctttgtg ctgggtgcaa atctgaatgg
     2461 tggcgagcgg cttgtgtctt acccctatga catggcccgg acacctagcc aggagcagct
     2521 gttggccgcg gcactggcag ctgcccgtgg agaagacgag gatgaggtgt ctgaggccca
     2581 ggagactcca gatcacgcca ttttccgctg gctggctatc tcctttgcct ctgcccatct
     2641 caccatgact gagccctacc ggggagggtg ccaggcccag gactacacca gcggcatggg
     2701 tatcgtcaac ggggccaagt ggaatcctcg gtctgggact ttcaatgact tcagctacct
     2761 gcataccaac tgcctggagc tctctatata cctgggctgc gacaagttcc cccacgagag
     2821 cgagctgccc cgagagtggg agaacaacaa agaagccttg ctaaccttca tggagcaggt
     2881 gcaccgtggc atcaagggtg tggtgacgga tgagcaaggg atccccattg ccaatgctac
     2941 catctctgtg agtggcatca accacggagt aaagacagcg agtggaggtg actactggcg
     3001 cattctgaac ccgggtgagt accgtgtgac agctcacgca gagggctaca cctcgagtgc
     3061 caagatttgc aacgtggact acgatatcgg ggccacccag tgcaacttca tcctggcgcg
     3121 ctccaactgg aagcgcattc gggagatctt ggctatgaac gggaaccgtc ccattctccg
     3181 agttgacccc tcacgaccaa tgacacccca gcagcggcgc ctgcagcagc gccggctacg
     3241 gtaccggctc aggatgaggg aacagatgag gctgcggcgc ctcaattcta ccacaggccc
     3301 tgccacgagc cccactcctg cccttacgct gcctccttcc cctacaccag gcagtacctc
     3361 gaggctctgg gaaattctac ccactaccgc tgcgggctgg gaggagtcag agactgagac
     3421 ctatacagag gtagtgacag agtttgagac agagtatggg cctgacctgg aggtggagga
     3481 actggaggag gaggaggagg aggaggagga gatggacaca ggcctcacgt ttccagtcac
     3541 aacagtggag acctacacag tcaactttgg ggacttctga gactggggtc ccaaagccct
     3601 agcccaattc aaactaaagc agcatttccc cagcctgtgc tggcaggcgc atagccatca
     3661 gatgctcctg ggtgggccct gttaccacca ggcctccaaa agcagagtct ctgcagaagc
     3721 ccccggttct acctgccagc ctttggggag gcaaggaagc caacgtcaca ccaataaaac
     3781 aagctcacgg cacca
//
LOCUS       NM_001437536            5893 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus CDC42 binding protein kinase gamma (Cdc42bpg),
            transcript variant 1, mRNA.
ACCESSION   NM_001437536 XM_006230751
VERSION     NM_001437536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5893)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   2  (bases 1 to 5893)
  AUTHORS   Ng,Y., Tan,I., Lim,L. and Leung,T.
  TITLE     Expression of the human myotonic dystrophy kinase-related
            Cdc42-binding kinase gamma is regulated by promoter DNA methylation
            and Sp1 binding
  JOURNAL   J Biol Chem 279 (33), 34156-34164 (2004)
   PUBMED   15194684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006230751.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.5578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  213037913-213038250
            339-430             JAXUCZ010000001.1  213040617-213040708
            431-514             JAXUCZ010000001.1  213040790-213040873
            515-610             JAXUCZ010000001.1  213041214-213041309
            611-759             JAXUCZ010000001.1  213041709-213041857
            760-853             JAXUCZ010000001.1  213042483-213042576
            854-1054            JAXUCZ010000001.1  213042713-213042913
            1055-1303           JAXUCZ010000001.1  213043008-213043256
            1304-1383           JAXUCZ010000001.1  213043655-213043734
            1384-1481           JAXUCZ010000001.1  213044724-213044821
            1482-1562           JAXUCZ010000001.1  213044920-213045000
            1563-1669           JAXUCZ010000001.1  213045199-213045305
            1670-1849           JAXUCZ010000001.1  213045401-213045580
            1850-1933           JAXUCZ010000001.1  213045784-213045867
            1934-2055           JAXUCZ010000001.1  213046010-213046131
            2056-2131           JAXUCZ010000001.1  213046216-213046291
            2132-2238           JAXUCZ010000001.1  213046509-213046615
            2239-2353           JAXUCZ010000001.1  213046692-213046806
            2354-2502           JAXUCZ010000001.1  213047105-213047253
            2503-2591           JAXUCZ010000001.1  213047330-213047418
            2592-2644           JAXUCZ010000001.1  213047654-213047706
            2645-2743           JAXUCZ010000001.1  213047796-213047894
            2744-2803           JAXUCZ010000001.1  213047975-213048034
            2804-2909           JAXUCZ010000001.1  213048285-213048390
            2910-3043           JAXUCZ010000001.1  213048661-213048794
            3044-3183           JAXUCZ010000001.1  213048876-213049015
            3184-3265           JAXUCZ010000001.1  213049110-213049191
            3266-3482           JAXUCZ010000001.1  213050234-213050450
            3483-3545           JAXUCZ010000001.1  213052197-213052259
            3546-4145           JAXUCZ010000001.1  213052355-213052954
            4146-4243           JAXUCZ010000001.1  213053894-213053991
            4244-4328           JAXUCZ010000001.1  213054074-213054158
            4329-4449           JAXUCZ010000001.1  213054275-213054395
            4450-4567           JAXUCZ010000001.1  213054497-213054614
            4568-4691           JAXUCZ010000001.1  213054813-213054936
            4692-4780           JAXUCZ010000001.1  213055050-213055138
            4781-5893           JAXUCZ010000001.1  213056652-213057764
FEATURES             Location/Qualifiers
     source          1..5893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5893
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CDC42 binding protein kinase gamma"
                     /db_xref="GeneID:293693"
                     /db_xref="RGD:1307260"
     exon            1..338
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4837
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase MRCK gamma; CDC42 binding
                     protein kinase gamma (DMPK-like)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform 1"
                     /protein_id="NP_001424465.1"
                     /db_xref="GeneID:293693"
                     /db_xref="RGD:1307260"
                     /translation="MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRE
                     RNVAQFLSWAGPFVTKVKELRLQRDDFEILKVIGRGAFGEVAVVRQRDSGQIFAMKML
                     HKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLL
                     SRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCL
                     RLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF
                     YAESLVETYGKIMNHEDHLQFPSDVDDVPASAQALIRQLLCRQEERLGRGGLDDFRSH
                     PFFEGVDWERLATSTAPYIPELRGPVDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLP
                     FVGFTYTSGSLTDDKSSELMATPEWKPHGVEQMKVELSQKCQEALHSSLQPQELVRLQ
                     KEVQVLQEKLTETLRDSKASLSQADGLHVRSPAPDIQLQQEKDRLQQELAEAQAALQV
                     RDAELCQAQNRQEEFLQRLWEAQEREAAAASQIQALNSQLEEAWVVRRELEGQVNTLS
                     QEVTQLQGQCKQDSSSQAKTVHAAPETNGIGSPEGQSQEAQLRKEVAALREQLECACS
                     QGVNVGKEEVLCRLQEENQRLSREQERLAEELDLELQSRQRLEGERRESESNWEAQIA
                     DILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPTRPLDHQWKARRLQKMEAS
                     ARLELQSALEAEIRAKQGLQEQLTQVQEAQRQAERRLQEAEKQNQALQQEVAELREEL
                     QARGPGDAKPCTSLIPLLSFWNTEKDSAKDPGNSGESPRSGAEAELRPEGRRSLRMGS
                     VFPRVPAANPTPAEGPPAKPGSHTLRPRSFPSPTKCLHCTSLMLGLGRQGLGCDTCGY
                     FCHSACATQAPPCPVPPELLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVYAA
                     LSDSRLLLFDAPDPRGSMASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRV
                     TASQLTVPPSTCTVLLLAENEGERERWLQVLSELQRLLLDARPRPRPVYTLKEAYDNG
                     LPLLPHTLCAAIIDRERLALGTEEGLFVIHLHSNDIFQVGDCRRVQRLTVSSAAGLLV
                     VLCGRGPSVRLFTLSELENAEVAGAKIPESRGCQALVAGSILQARTPVLCVAVKRQVL
                     CYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNEAAPLALGT
                     GLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDGAGRKSRSHELLWPVAPT
                     GWGYTAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLLLYGTEKVRLTYL
                     RNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRSKF
                     ISPPTNFNHLVHVGPTEGRPGPRDGTRAQEQKSRGTRSSGPQRPHSFSEALRRPVSMG
                     NDGLPGETDPLVKRKVWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESEGSP
                     "
     misc_feature    383..1375
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; Region:
                     STKc_DMPK_like; cd05597"
                     /db_xref="CDD:270748"
     misc_feature    383..1375
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; Region:
                     STKc_DMPK_like; cd05597"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     620..625,629..631,641..643,647..649,761..763,767..769,
                     773..778,782..784,812..817,824..826,869..886,980..982,
                     998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="active site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     620..625,629..631,641..643,647..649,761..763,767..769,
                     773..778,782..784,812..817,824..826,869..886,980..982,
                     998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="active site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     623..631,641..643,761..763,767..769,773..778,782..784,
                     812..817)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(407..421,431..433,470..472,476..478,572..574,
                     623..631,641..643,761..763,767..769,773..778,782..784,
                     812..817)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(419..421,641..643,647..649,761..763,767..769,
                     773..775,824..826,869..886,980..982,998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(419..421,641..643,647..649,761..763,767..769,
                     773..775,824..826,869..886,980..982,998..1000,1007..1009)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270748"
     misc_feature    order(812..844,851..886)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270748"
     misc_feature    order(812..844,851..886)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270748"
     misc_feature    1355..1372
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270748"
     misc_feature    1355..1372
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270748"
     misc_feature    <1514..>2581
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <1514..>2581
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    2813..2968
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; Region:
                     C1_MRCKgamma; cd20866"
                     /db_xref="CDD:410416"
     misc_feature    2813..2968
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; Region:
                     C1_MRCKgamma; cd20866"
                     /db_xref="CDD:410416"
     misc_feature    order(2828..2848,2870..2884,2891..2893)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="putative DAG/PE binding site [chemical binding];
                     other site"
                     /db_xref="CDD:410416"
     misc_feature    order(2828..2848,2870..2884,2891..2893)
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="putative DAG/PE binding site [chemical binding];
                     other site"
                     /db_xref="CDD:410416"
     misc_feature    2990..3388
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; Region: PH_MRCK;
                     cd01243"
                     /db_xref="CDD:269949"
     misc_feature    2990..3388
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; Region: PH_MRCK;
                     cd01243"
                     /db_xref="CDD:269949"
     misc_feature    3482..4258
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     misc_feature    3482..4258
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:459938"
     exon            339..430
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            431..514
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            515..610
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            611..759
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            760..853
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1054
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1303
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1383
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1481
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1562
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1669
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1849
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1933
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2055
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2131
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2238
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2353
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2502
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2591
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2644
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2743
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2803
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2909
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3043
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3183
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3265
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3482
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3545
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..4145
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4243
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4328
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4449
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4567
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4691
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..4780
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..5893
                     /gene="Cdc42bpg"
                     /gene_synonym="RGD1307260"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggccag gtgaaggagc gcgggtgtcg acggaggaag gtgacagcgg ggagggcggg
       61 agggaggggg gaagccgagc aggacgagct gcggaaccac ggaccgaccg ccggacggac
      121 ggacggggca tgcgggcggc ctggctctag cccgggttac ggggctccag ccgcagccat
      181 ggagcagcgg ctgcgtgcgc tggagcagtt ggtacggggc gaggctggtg gcagcccggg
      241 gctcgacggc ctcctggatt tgctgctggg ggtgcaccag gagctcagca gcgcccccct
      301 gcgccgggag cgtaacgtgg cgcagtttct gagctgggct ggcccctttg taacaaaagt
      361 gaaagagctg cgtttacaga gagatgactt tgagatcttg aaggtgattg gcagaggggc
      421 ctttggggag gttgctgtgg tgaggcagag ggacagtggc cagatttttg ccatgaagat
      481 gctgcataag tgggagatgc tgaagagggc tgagacggcc tgtttccggg aggagcgaga
      541 tgttctagtg aagggagata gccgctgggt gactgctctg cactacgcct tccaagatga
      601 ggagtacctg tacctggtga tggactacta cgctggcggg gacctcctca cactgctgag
      661 ccgcttcgag gatcgcctcc cacctgagct ggcccagttc tatctggctg agatggttct
      721 ggccatccac tctctgcacc agctgggcta tgtccacagg gatgtcaagc ctgacaacat
      781 cctgctggac atgaatggcc acatccgcct ggcagacttt ggctcctgcc tgcgtctcaa
      841 caacaatggc atggtggatt catcagtcgc agttgggacc ccggactaca tctctcctga
      901 gatcctacag gccatggagg aaggcaaggg ccactacggc ccacagtgtg actggtggtc
      961 cctgggagtc tgcgcctacg agctgctctt tggggaaaca cccttttatg cagagtctct
     1021 ggtagaaacc tacggcaaga tcatgaacca cgaggaccac ctccagttcc cctctgatgt
     1081 agatgacgtg cctgctagtg cccaggccct gatccggcag ctgctgtgcc gtcaggagga
     1141 gcggctgggc cgcggtggac tggacgactt ccggagccac ccgttctttg aaggggttga
     1201 ttgggagaga cttgcaacca gcacagcacc ctacatccct gagcttcgcg ggccggtgga
     1261 tacctccaac ttcgatgtgg atgatgatac cctcaaccgt ccagagacgc tgccaccgtc
     1321 ctcccacggg gccttctcag gccaccacct gccatttgta ggcttcactt atacctcagg
     1381 cagcctcact gatgacaaga gctctgagct aatggctacc ccagagtgga agccccacgg
     1441 tgtggagcag atgaaagtgg agctcagcca gaagtgtcaa gaggccctgc atagctcatt
     1501 acaaccccag gagctggtgc gactgcagaa agaagtacag gttcttcagg agaaactgac
     1561 agagacactg agggacagca aggcctcact ctcacaggct gatggcctcc atgttagaag
     1621 cccagcccca gacatccaac tacaacagga gaaggaccgc ctccagcagg agctggctga
     1681 agctcaggca gcattgcaag tgcgggatgc tgaactgtgc caagcccaga accgacagga
     1741 agaattccta cagaggctgt gggaagccca agagagagag gcagctgcag ccagtcagat
     1801 ccaggccctg aactcccagc tggaggaagc ctgggttgtc cggagagagc ttgaaggcca
     1861 ggtgaacacc ctgagtcagg aggtgacaca gctccaggga caatgtaaac aagactcttc
     1921 ttcacaggcc aagaccgttc atgcagcccc tgagaccaac ggcataggat ctcctgaggg
     1981 tcagtctcaa gaggcccagc tgaggaagga ggtggctgct ctgagggagc agctggagtg
     2041 cgcctgcagc caaggggtca atgttgggaa agaggaggtt ctgtgccgac tgcaggagga
     2101 aaaccagcgg ctgagccggg agcaggaacg gttggcagag gagctggacc tggagctaca
     2161 gagcagacag cgtctggaag gtgagcggcg tgagagtgag agcaactggg aggcgcagat
     2221 tgctgacatc ctcagctggg tgaatgacga gaaggtctcg agaggctacc tgcaggcctt
     2281 ggctactaag atggccgagg agctggagtc cttgaggaat gtgggcaccc aaacactccc
     2341 tacccggcct ctggaccacc agtggaaggc tcggaggctg cagaagatgg aggcctcagc
     2401 ccggcttgag cttcagtcag cactggaagc tgagatccgt gccaagcagg gtctgcagga
     2461 gcagctgacg caggtgcagg aggcccagcg gcaggctgaa cgccgccttc aagaggctga
     2521 gaagcaaaac caggccctgc agcaggaggt ggctgagctc cgggaggaac ttcaagctcg
     2581 aggaccaggg gatgccaagc cctgtacctc cctcatccct ctcctgtcct tctggaacac
     2641 agagaaggat tctgccaagg accctggcaa ttcaggagag tccccccggt ctggagcaga
     2701 agcagagctg aggccagagg gccgccgcag tttgcgcatg gggagtgtgt tccccagggt
     2761 gcctgctgcc aaccctaccc ctgcagaggg tcctcctgct aagcctggtt ctcacacact
     2821 gcgtccccgg agttttccat cccctaccaa gtgtctccac tgcacctcgc tgatgttggg
     2881 cctgggccgc cagggcctgg gctgtgacac ctgtggctac ttctgccact cagcttgtgc
     2941 gacccaagcc ccaccctgcc ctgtgccccc tgaactcctc cgcacagccc tgggggtgca
     3001 cccggaaaca ggcacaggca ctgcctatga gggcttcctg tcggtgcctc ggccttcagg
     3061 tgtccgtcgg ggttggcaga gggtgtatgc tgctctcagt gactcccgcc tgttgttgtt
     3121 tgacgctcct gaccctcgag gcagcatggc cagtggggtc ctcctgcagg ccttggatct
     3181 gagggatccc cagttctcag ccacccctgt cttagctcca gatgtcatcc atgcccaatc
     3241 caaggacctg ccacgcatct ttagggtgac agcctcccag ctgacagtgc caccatccac
     3301 atgtactgtg ctgctgctgg cagagaacga gggggagcgg gagcgttggc ttcaggtgct
     3361 aagtgagctg cagcggctgc tcctggacgc acgcccaagg ccccgaccag tgtacacact
     3421 caaggaggcc tatgacaatg gactgccgct gctgcctcat acgctctgtg ctgctatcat
     3481 tgaccgagag cgtcttgccc tgggcactga ggagggcttg tttgtgatcc atcttcacag
     3541 caatgacatc ttccaggtgg gagactgccg cagggtgcag cggttgaccg tgagctctgc
     3601 cgctggccta ctggtcgtgc tctgtggccg tggtcccagt gtgcgcctct tcaccctgtc
     3661 tgagctggaa aatgcagagg tggcaggtgc caagatccct gaatcccgag gctgtcaggc
     3721 tttggtggct gggagcatcc tacaggcccg gactccagtg ctctgtgtgg cagtcaagcg
     3781 ccaagttctc tgttaccagc tgggcccagg accagggccc tggcagcgcc gcatccgaga
     3841 gctacaagcg ccagctcccg tgcagagcct ggggttgctg ggtgatcggc tctgtgtggg
     3901 tgccgctggc acctttgctc tctacccgct gctcaatgag gctgcgccct tagcgctggg
     3961 aaccggcctg gtggctgagg agctccccgc gtcccgtggg ggcctgggtg aggcactggg
     4021 tgctgtggag ctcagcctca gcgagcttct gctgctcttc gccactgctg gcgtctacgt
     4081 ggatggcgct ggccgcaagt cacgaagcca cgagctgctg tggccagtgg cacccactgg
     4141 ctggggttac acagcaccct acctaacagt gttcagtgaa aactccattg atgtgtttga
     4201 tgtgaggaga gcagaatggg tacagactgt gccactcaag aaggtaagac ccctaaatcc
     4261 agaaggctcc ttgctcctct atggcaccga gaaggtccgt ctgacctacc tcaggaatcc
     4321 attagcagag aaggatgagt ttgacattcc cgacctcacg gacaacagcc ggcgccagct
     4381 gttccgcacc aagagcaagc gccgcttctt cttccgggtg tctgacgagc tgcggcagca
     4441 gcagcgcagg gagatgctga aggacccttt tgtgcgctcc aagttcatct caccgcccac
     4501 caacttcaac cacctggtgc acgtgggccc tacagagggc aggcccggcc ccagggatgg
     4561 gacccgggct caggaacaga agagcagagg cacccgcagc tccggaccgc agcggcccca
     4621 cagcttctca gaggcattgc ggcgtccagt atccatgggc aatgatggcc tccctggaga
     4681 aacagacccc ctagtgaaga ggaaagtttg gacatctctg tccagcgaat ccgtgtcctg
     4741 cccccagggg tccctgagcc ctgcagcatc cctgatacag gtctcagaac ggccccggag
     4801 tctccctcca gatcctgagt cagagggctc cccctgatgc cctctggcag tgcccacccc
     4861 attcccaaga cagaaggaat gaggaagcaa agagcttgag ggatgccata cccggctggt
     4921 ccgggacatg ttgaaattca gactcaggga gagcctgggt ggagggctaa gagcaaggcg
     4981 cgcctgggtc cccaggagtg gggtctggct cctggcccta ttcctgccat tctcctgggc
     5041 ttccatcaca gcctacactg gcctctggga gtgccacgcc tttactgccc agggaagatt
     5101 gtgccaaagc tatgcttcat agggccaggg acgcagttag tcaggggagg aatggagggc
     5161 gggtccttgg gagtgtgctg gtgtcttgtc tgcagcctgg cccaggctga ggccgagatg
     5221 gagcatgtga ggtctctgct cagggtcagg ctgggctctg gttgacaaga aaaggattga
     5281 aaagagagag tgaggtaagt gagagagaga gagagaggag aggtgaggga gcaaaggcag
     5341 cagaggagga agtgatggaa tcaggagatg gatgctaact gagaaagagg agagaaggac
     5401 aaagcatgta gtgaggagga tgctggagag acagaaggga aggagggaga atgagccagg
     5461 gaaagcccga cccaggagct tttctctagg gtggggctca ggagtgagag cagggctatt
     5521 gctaggttat ccgtccagga aaaatggttc ctaggcaggg aggggatggg agggtattta
     5581 taagggcttc ttggtgggag atagacaccc ttcggggacc actaaatatc tccaggcaca
     5641 cgtcggccct tcccagcagg aagggtcctt ttctggaagc ttcaaccaag tgtattaggg
     5701 gaacataggg ggcattttaa tattgatcac agtcattatt attgttatta tattgctatt
     5761 tttattaaac ctcgccctgc tacagtgtag ggaatgaaag aagtatttat ctctttgaat
     5821 gccacagtcc cgggatggat gggctctgat gcaccgagat gtggcaagaa acaataaagc
     5881 caactttaca agc
//
LOCUS       NM_001437503            6318 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 532 (Zfp532), transcript
            variant 1, mRNA.
ACCESSION   NM_001437503 XM_006254865
VERSION     NM_001437503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254865.5.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360172.2764272.1, SRR26360194.224558.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000018.1  61364771-61365118
            349-458             JAXUCZ010000018.1  61366855-61366964
            459-2812            JAXUCZ010000018.1  61414137-61416490
            2813-2994           JAXUCZ010000018.1  61428974-61429155
            2995-3171           JAXUCZ010000018.1  61433813-61433989
            3172-3334           JAXUCZ010000018.1  61440821-61440983
            3335-3616           JAXUCZ010000018.1  61445638-61445919
            3617-3729           JAXUCZ010000018.1  61467135-61467247
            3730-3880           JAXUCZ010000018.1  61469855-61470005
            3881-6318           JAXUCZ010000018.1  61471223-61473660
FEATURES             Location/Qualifiers
     source          1..6318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6318
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc finger protein 532"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
     exon            1..348
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            349..458
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    371..373
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="upstream in-frame stop codon"
     exon            459..2812
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..4375
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 532 isoform 1"
                     /protein_id="NP_001424432.1"
                     /db_xref="GeneID:307362"
                     /db_xref="RGD:1311719"
                     /translation="MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHIKQN
                     AHVDDDSHTPSSSDVGVSVIVKNVRNIDSSEGVEKDGHNPTGNGLHNGFLTASSLDSY
                     GKDGAKSLKGDTPASEVTLKDPAFSQFSPISSAEEFEDDEKIEVDDPPDKEETRANFR
                     SNVLTGSAPQQDFDKLKALGGENTSKTGVSASGHADKNKVKREAESNSITLSVYEPFK
                     VRKAEDKLKENSEKMLESRVLDGKPSSEKNDPAIAAATSSKTKSSSKLSSCIAAIAAL
                     SAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKSPESQNLIDGTKKASLKPSDSP
                     RSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPS
                     EQAASVMASVTSLLSSSASAAVLSSPPRAPLPTAMVTSAVSSAELTPKQVTIKPVATA
                     FLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPA
                     SSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAILNAAAAQPPKKV
                     SRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPASAGITLPMRGYKCLECGDSF
                     ALEKSLSQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILK
                     PVPADQMIVSPSSNTAASTLPSSVGAATHTVAKVQPGLTGAVISAPPSTPISPAMPLD
                     EDPSKLCRHSLKCLECNEVFQDETSLATHFQHAADTCGQKTCTVCQMLLPNQCSYASH
                     QRIHQHKSPYTCPECGAICRSVHFQSHVTKNCLHYTRRVGFRCVHCNVVYSDVAALKS
                     HIQGSHCEVFYKCPICPMAFKSAPSTHSHAYTQHPGVKIGEPKIIYKCSMCDTVFTLQ
                     TLLYRHFDQHIDNQKVSVFKCPDCSLLYAQKQLMMDHIKSMHGTLKSIEGPPNLGINL
                     PLSSKPATQNSANHSREDAKSMNGKEKLEKKSPSPAKKSTESKKMASLGWTCWECDRL
                     FTQRDVYLSHMRKEHGKQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACSHCP
                     DSRRTFTKRLMLEKHIQLMHGIKDPDVKELSDEVTNEEEVEIKEDAKVPSPKRKLEEP
                     VLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHKSDGSSYQCR
                     ECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGEDSQQENKPSPEDEAAEGAVSDR
                     KCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK"
     misc_feature    2732..2791
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2732..2791
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2747..2749,2753..2755,2759..2761,2765..2770,
                     2777..2782,2834..2836,2840..2842,2852..2857,2864..2869,
                     2876..2878,2921..2923,2927..2929,2933..2938,2945..2950)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2747..2749,2753..2755,2759..2761,2765..2770,
                     2777..2782,2834..2836,2840..2842,2852..2857,2864..2869,
                     2876..2878,2921..2923,2927..2929,2933..2938,2945..2950)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2816..2923
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C4-type zinc ribbon domain; Region: zf-RING_7;
                     pfam02591"
                     /db_xref="CDD:426857"
     misc_feature    2816..2923
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C4-type zinc ribbon domain; Region: zf-RING_7;
                     pfam02591"
                     /db_xref="CDD:426857"
     misc_feature    2819..2881
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2819..2881
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2903..2953
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2903..2953
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2996..3049
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2996..3049
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3080..3145
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3080..3145
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3185..3247
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3185..3247
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3545..3607
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3545..3607
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(3560..3562,3566..3568,3572..3574,3578..3583,
                     3590..3595,3602..3604,3650..3652,3656..3658,3668..3673,
                     3680..3685,3692..3694,3749..3751,3755..3757,3761..3763,
                     3767..3772,3779..3784)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(3560..3562,3566..3568,3572..3574,3578..3583,
                     3590..3595,3602..3604,3650..3652,3656..3658,3668..3673,
                     3680..3685,3692..3694,3749..3751,3755..3757,3761..3763,
                     3767..3772,3779..3784)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    3635..3700
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3635..3700
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3725..3787
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3725..3787
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3995..4057
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    3995..4057
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(4010..4012,4016..4018,4022..4024,4028..4033,
                     4040..4045,4052..4054,4097..4099,4103..4105,4115..4120,
                     4127..4132,4142..4144,4280..4282,4286..4288,4292..4294,
                     4298..4303,4310..4315,4322..4324)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(4010..4012,4016..4018,4022..4024,4028..4033,
                     4040..4045,4052..4054,4097..4099,4103..4105,4115..4120,
                     4127..4132,4142..4144,4280..4282,4286..4288,4292..4294,
                     4298..4303,4310..4315,4322..4324)
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    4070..4150
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    4070..4150
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="zinc-finger C2H2-type; Region: zf-C2H2_11;
                     pfam16622"
                     /db_xref="CDD:465205"
     misc_feature    4082..4147
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    4082..4147
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    4262..4327
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    4262..4327
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2-type zinc finger; Region: zf-C2H2_6;
                     pfam13912"
                     /db_xref="CDD:433576"
     misc_feature    4265..4327
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    4265..4327
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            2813..2994
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3171
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3334
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3616
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3729
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3880
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..6318
                     /gene="Zfp532"
                     /gene_synonym="Znf532"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgttcg ctcgccgccc gggcggcccg agcgctaggc cccggcgtgg cccgggccga
       61 gccgccgccg cgcggcctag agcccgcgcc ccggagcggg gccggcgtcc gggcgcaccg
      121 cgaggccgcg gcagcgagga gccctagggc ggcgaggccg ggctccgctc tcgcacacag
      181 accccggcgg cggggaggcg cgacacgccc gtagcatgga agcggccgcc gctcgcactg
      241 cagcgggcgc agcagcagca gccgccggcg gcgcgcggag cagaggtcgc ccgagccacg
      301 gcccggacac ccgggcttga gcgctacgga ggcccgcccg gccagggggc ctgttgactg
      361 gggctgcttt taaccctttc ctatttgcag agaatgcaac cgtgtgacag taactgagca
      421 ctggtccaaa gtcttttcaa aaggtcaagg ttcacaagaa catctgatca aattcatgac
      481 catgggggat atgaagaccc cagactttga tgacctcttg gcagcgtttg acataccaga
      541 tatggttgat cctaaagcag ccattgagtc tgggcacgat gaccacgaaa gccacattaa
      601 gcagaatgct cacgtggatg acgactctca cacaccatca tcctcagatg ttggcgttag
      661 tgtgattgtg aagaatgttc gcaacatcga ctcctctgag ggagtggaaa aagatggcca
      721 caatcccaca ggcaatggct tgcataacgg gtttctcacg gcctcctctc ttgacagcta
      781 tggtaaggat ggagccaagt ccttaaaagg agacacacct gcctcagagg tgactcttaa
      841 agacccagcg ttcagccagt tcagccccat ctccagcgcc gaggagtttg aggatgatga
      901 gaaaatagag gtggatgacc cacctgataa ggaggagacg agggccaatt tcagatcaaa
      961 tgtgctgacg ggctccgctc cccagcagga cttcgacaaa ctgaaggcac ttggagggga
     1021 aaacacaagc aagactggag tctctgcatc aggtcatgca gataaaaaca aagtcaagag
     1081 agaagcagaa agcaattcca taaccctgag tgtctatgag ccgtttaagg tcagaaaagc
     1141 agaggataag ttgaaggaga actctgagaa gatgcttgaa agcagggtcc tggatgggaa
     1201 gccgagctcc gagaagaacg accctgccat tgctgctgcc acatcttcca aaacaaagtc
     1261 gtcctccaag ctctcgtcgt gcatagccgc cattgcggct ctgagtgcga aaaaggctgc
     1321 atctgactcc tgcaaagagc ctgtggccaa ttccagggaa gcatctccac taccaaaaga
     1381 agtgaatgac agtcccaaag ccgctgacaa gtctccggaa tcccagaatc tcatcgatgg
     1441 caccaagaag gcctctctga agccgtcaga tagtcccagg agcgtatcca gtgagaacag
     1501 cagcaaaggg tccccatcct ctcctgtggg gtctacccca gctatcccca aagtccgcat
     1561 caagaccatc aagacatcat ctggggagat caagaggaca gtgaccagag tactgccaga
     1621 agtggatctg gactctggga agaagccttc tgagcaggca gcgtccgtga tggcgtctgt
     1681 gacgtcactt ctgtcatctt cagcatcagc tgcggtcctc tcctcacccc ccagggcacc
     1741 tctgccgaca gccatggtta ccagtgcggt ttcctctgca gagctgactc ccaaacaggt
     1801 aaccatcaag cccgtggcta cagcttttct tcctgtgtct gccgtcaaga cagcagggtc
     1861 tcaagtcatc aacctgaagc tggctaacaa cacaacggtg aaagccacgg tcatctcggc
     1921 tgcctctgtt cagagcgcca gcagtgccat catcaaagct gccaatgcca tccagcagca
     1981 aaccgttgtg gtgccggcct ccagtctggc caatgccaaa ctcgtgccaa agactgtgca
     2041 ccttgccaac cttaacctcc tgcctcaggg tgcccaggcc acctctgaac tccgccaagt
     2101 gctcaccaaa cctcagcagc aaataaagca ggcaatactc aatgccgcgg ccgcgcagcc
     2161 acccaagaag gtgtcccggg tccaggtggt gtcctccttg cagagttctg tggtggaagc
     2221 tttcaacaag gtgctgagca gcgtcaaccc agtccctgtt tacatcccga acctcagtcc
     2281 tcccgccagt gccgggatca cgttaccgat gcgcgggtac aagtgcttgg agtgcgggga
     2341 ctccttcgcc ctggaaaaga gcctgagcca gcactacgac aggcgcagcg tgcgcatcga
     2401 agtgacgtgc aaccactgta cgaagaacct tgttttttac aacaagtgca gcctcctttc
     2461 ccacgcccga gggcataagg agaaaggcgt ggtgatgcag tgctcccact taatcctaaa
     2521 accagtccca gcagaccaga tgatagtgtc tccgtccagc aatactgctg cttccactct
     2581 gccgagctcg gtgggagctg ccacacacac tgtcgccaaa gtacagcctg gcctaaccgg
     2641 ggcggttatc tcagctcctc caagcacacc catcagccca gccatgcccc tagacgaaga
     2701 cccctccaag ctctgtagac acagtctcaa gtgtttggag tgcaatgaag tcttccagga
     2761 tgagacgtcc ctggccacac atttccagca tgccgcagac acatgtggac aaaagacttg
     2821 cactgtctgc cagatgctgc ttcctaacca gtgcagctat gcctcacacc agagaatcca
     2881 tcagcacaaa tctccctaca cctgccccga gtgcggggcc atctgcaggt cggtgcactt
     2941 ccagagccac gtcaccaaga actgcctgca ctacacacgg agagttggct ttcgatgtgt
     3001 acattgcaat gttgtgtact ctgatgtggc cgcactgaag tctcacattc aaggctctca
     3061 ctgtgaagtc ttctacaagt gccctatctg tccaatggcg tttaagtctg ccccaagtac
     3121 acattcccac gcctacacgc agcatcctgg cgtcaagata ggagaaccaa aaataatcta
     3181 taagtgttcc atgtgcgaca ctgtgttcac cctgcaaacc ttgctgtatc gccactttga
     3241 ccagcacatt gacaaccaga aggtgtctgt tttcaagtgt ccagactgtt ctcttttata
     3301 tgcccagaag caacttatga tggaccatat caagtctatg catggaacat tgaaaagtat
     3361 tgaagggcct ccaaacttgg gtataaactt gcctttgagc agtaagcctg caactcagaa
     3421 ttcagcaaac cacagcagag aggatgccaa gtccatgaat gggaaagaga aattggaaaa
     3481 gaagtctcca tctcctgcaa agaaatccac agaatctaag aagatggcca gtctcgggtg
     3541 gacgtgttgg gagtgtgacc gtctgttcac acagagggat gtgtatctgt ctcacatgag
     3601 gaaggagcat gggaagcaaa tgaagaagca cccctgccgc cagtgtgaca agtctttcag
     3661 ctcctcccac agcctgtgcc gccacaatcg catcaagcac aaaggcatca ggaaggttta
     3721 cgcctgctcg cactgcccag actcccgtcg gaccttcacc aagcggctga tgctggagaa
     3781 gcacatacag ctgatgcacg ggatcaaaga ccctgacgta aaggagctga gtgacgaggt
     3841 taccaacgag gaggaagtgg agataaagga ggacgccaag gttcccagtc ctaagcggaa
     3901 gttggaggag ccagttttag agttcaggcc tccccgagga gccatcactc agccactgaa
     3961 gaaactgaaa atcaatgtct ttaaggtcca caagtgcgcc gtgtgtggct tcaccactga
     4021 gaacctgctg cagttccacg aacacatccc ccagcacaag tcggacggct cctcctacca
     4081 gtgccgggag tgcggcctgt gctacacgtc ccacgtctcc ctgtccaggc acctcttcat
     4141 cgtgcacaag ctgaaggagc ctcagcctgt gtccaagcag aacggggctg gggaagacag
     4201 ccagcaggag aacaagccca gcccggagga tgaggccgcc gagggggcag tgtcagacag
     4261 gaagtgcaaa gtgtgcgcca aaactttcga aacggaagct gccttaaaca cacacatgag
     4321 gacacacggc atggccttca tcaagtccaa aagaatgagt tcagctgaaa aatagccaca
     4381 gaacttccat aagaacaatc cctgtccaca taggaattga acgtttttgt taccaaaagt
     4441 ttgcagtata acagagttac cagttctgtc taggctgtgg caatagactc tttgtcctgc
     4501 cctctcacct cagatgtatc ccttcccata agtgttaagg cagtatttga gttttaaaga
     4561 gtttgtatat atttaaataa cattttatac tctttgttac atgtttgtat cagtatttgg
     4621 tggaaaatgt tttgagggtt ttttttgtgt gtgtatgtta ggattctctt tttttgtact
     4681 gtttctttaa aacagagttc ttaggggaag ttcctgaatt caaaccaacc attttgtatg
     4741 ttgagaattt gaatgagttc agtaattaca ggctatcatg ccttttttag tgtttttaat
     4801 ttttagaact cgccacataa attataggtg attgtgggtc acacaacact agcaactttt
     4861 aagtgtctta gcaccacact cagcgtgcct gctcctagca accgagggct ccaaggacag
     4921 catcacccag ttaagggcgt ggcctgagcc atcccagaca gtgtgggaag cagccttaca
     4981 ggtccctcct ttgccatagt aggtaaaaga ggccaggaat ccagtaggga gtgcggtcgt
     5041 ccttaatccc aactggaaga atgaggaaga agggatccat aaaggggaga cagtggagct
     5101 gggtgaattc gcaaggtgac ttacagggca caaggagaca ggctagggaa aggccagcct
     5161 gtggtcaaag ttgaaagtca tagttagacc tgtcgctctc tctgtcaggt tttgtcatgg
     5221 aactcaccaa cctttctaga gacacacact acaagagtac caagtatttc tctggctctt
     5281 gataggaaca gaaaggcacg gttgacttaa ccctttgctg tctacacagt tggtatttcc
     5341 tgttccgggt gctactgcca aatgttcggg tacttagtgt cgggatgcac agcctcacca
     5401 ccgacctagc actgcagcag cctgtactct gcaactggcc tgaggagcca ccaggcttct
     5461 agagtcgttt cagcaccctc tcaaggccgc ctgactggag caccgctgag gtgctcttcg
     5521 tcacatccct gcctagttct ctgagaaaac tatatatttt ggttattgtt ttgtgttttt
     5581 cgttgcattt tgtatcttgt atttatctcc cgatatgttt tgtacttttg ttttcctaaa
     5641 cgaggaaatt catttgtgta cataaatact tgcatgctaa actgtagtcc acgttcagtt
     5701 ccctgaaagg tcttgctgct gttggtgcgc accctacacc atcgtgactg tattcagccc
     5761 atttcacatg taaataaaac gaggaacatc tggcccttga gcttcttcaa gagagtcatt
     5821 ggtgggtctc tgacatcata cagttcgggg agtgactctt ttggggacag gctgcagaat
     5881 actgcagaat tctttccact ctgaagaatg gcttctcgtt ctcatcggcg accagctcac
     5941 taccctgccg ctttctgtcg actgtgtcga cacaatccaa gggtgcgaga tgttcctcag
     6001 cttgaaatgt aattgctgtt acgtgttaca tccgcaccgc tcccgccccc actcgtggtc
     6061 atggcacttt cacacgttcc tgcatttgaa ccttgcaata agcctgcgtg gcggccacgc
     6121 gggtctgtac agcttacagc tgaggaagct gcgctcaggt tcagctcttc gcccgacccc
     6181 tcatagctgg taagtggctt tgcatattag aacccaaata tttcgctctc agtctagtat
     6241 tctcgctctt tgtggctatg tacatattga cagatactca tttattcaac aaataaagtt
     6301 atgtgcaaaa acaccata
//
LOCUS       NM_001437244             910 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus LSM10, U7 small nuclear RNA associated (Lsm10),
            transcript variant 1, mRNA.
ACCESSION   NM_001437244 XM_006238895
VERSION     NM_001437244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006238895.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166902.1, FM099348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000005.1  143658391-143658539
            150-910             JAXUCZ010000005.1  143659631-143660391
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..910
                     /gene="Lsm10"
                     /note="LSM10, U7 small nuclear RNA associated"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
     exon            1..149
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     exon            150..910
                     /gene="Lsm10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Lsm10"
                     /note="upstream in-frame stop codon"
     CDS             174..542
                     /gene="Lsm10"
                     /note="U7 snRNP-specific Sm-like protein LSM10"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm10"
                     /protein_id="NP_001424173.1"
                     /db_xref="GeneID:366468"
                     /db_xref="RGD:1584914"
                     /translation="MALSHSVKERTISENSLIILLQGLQGQITTVDLRDESVARGRID
                     NVDAFMNIRLANVTYTDRWGHQVELDDLFVTGRNVRYVHIPDGVNITATIEQQLQIIH
                     RVRNFGGKGQGRREFPSKRP"
     misc_feature    195..428
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    195..428
                     /gene="Lsm10"
                     /note="Like-Sm protein 10; Region: LSm10; cd01733"
                     /db_xref="CDD:212480"
     misc_feature    order(258..278,282..320,324..338)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(258..278,282..320,324..338)
                     /gene="Lsm10"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    order(312..314,318..320,396..398)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    order(312..314,318..320,396..398)
                     /gene="Lsm10"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212480"
     misc_feature    384..419
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
     misc_feature    384..419
                     /gene="Lsm10"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212480"
ORIGIN      
        1 ggacttgtag tccgtgtcct gcgatgcgca tgctctgatg ctctgggtct cccgcggttg
       61 ccatggcttc tctgagcctc cgtgggtgtt cccctagaca caggcgggtt ttggcggcgt
      121 agcgcgcgga aggcggaagg catcacgcgt gagcagccaa ccaatgtgga aaaatggcac
      181 tgagccactc tgtgaaggag cgaaccatct ctgagaacag cctgatcatc ctgttgcaag
      241 gcctccaggg acaaataacc actgtggacc ttcgagatga gagtgtggcc cgaggacgca
      301 tcgacaacgt tgatgctttc atgaacatcc gtctggccaa tgtcacctac accgaccgct
      361 gggggcatca ggttgagttg gatgaccttt tcgtgacagg tcgtaatgtc cgatatgtcc
      421 atatcccaga cggtgtgaac atcactgcca caatcgagca gcagctacag atcatccacc
      481 gtgtgcgcaa ctttggtggc aagggtcaag gtcgtcgaga gttcccctcc aaaaggccat
      541 gagactgtgt cctcattcaa attccagcac cacctcaggg acctccagtg ttctgagcca
      601 actcccgtcc atccttcccc accaatgacc tggtgtctta tagacacatc acagctgcct
      661 ttcatagggt tccacttttc agacacacct tgggacccag aattccttct gctggtggcc
      721 ttggggtagg tgacaatccc tctttttgat catttgtatc tggaatctcc attcactgat
      781 tgaccccatc catcaaggag ttgttaactc tgccagtgag gattacttga gagtgtttgg
      841 agtgaatcac ctctaacatc ccatttctct tgtcatttgt ttcttttctc ataaaaccaa
      901 actcctggga
//
LOCUS       NM_001437398            4245 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 36 (Trim36),
            transcript variant 2, mRNA.
ACCESSION   NM_001437398 XM_006254686
VERSION     NM_001437398.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Singh,N., Kumble Bhat,V., Tiwari,A., Kodaganur,S.G.,
            Tontanahal,S.J., Sarda,A., Malini,K.V. and Kumar,A.
  TITLE     A homozygous mutation in TRIM36 causes autosomal recessive
            anencephaly in an Indian family
  JOURNAL   Hum Mol Genet 26 (6), 1104-1114 (2017)
   PUBMED   28087737
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Miyajima,N., Maruyama,S., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM36 interacts with the kinetochore protein CENP-H and delays
            cell cycle progression
  JOURNAL   Biochem Biophys Res Commun 381 (3), 383-387 (2009)
   PUBMED   19232519
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Kitamura,K., Tanaka,H. and Nishimune,Y.
  TITLE     Haprin, a novel haploid germ cell-specific RING finger protein
            involved in the acrosome reaction
  JOURNAL   J Biol Chem 278 (45), 44417-44423 (2003)
   PUBMED   12917430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254686.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.50055.1,
                                           SRR26643288.59442.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000018.1  41088223-41088526   c
            305-539             JAXUCZ010000018.1  41084042-41084276   c
            540-865             JAXUCZ010000018.1  41075830-41076155   c
            866-1012            JAXUCZ010000018.1  41073397-41073543   c
            1013-1108           JAXUCZ010000018.1  41065895-41065990   c
            1109-1362           JAXUCZ010000018.1  41061600-41061853   c
            1363-1487           JAXUCZ010000018.1  41061277-41061401   c
            1488-1778           JAXUCZ010000018.1  41059874-41060164   c
            1779-2076           JAXUCZ010000018.1  41049807-41050104   c
            2077-4245           JAXUCZ010000018.1  41046243-41048411   c
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4245
                     /gene="Trim36"
                     /note="tripartite motif-containing 36"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
     exon            1..304
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..2431
                     /gene="Trim36"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif protein 36; E3 ubiquitin-protein ligase
                     TRIM36"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM36 isoform 2"
                     /protein_id="NP_001424327.1"
                     /db_xref="GeneID:291597"
                     /db_xref="RGD:1308714"
                     /translation="MEGDASDSQVTIKNIEKELICPACKELFTHPLILPCQHSVCHKC
                     VKELLLSLDDSFNDVASDSSNQSSPRLRLTSPSMDKIDKINRPGWKRNSLTPRPTMFP
                     CPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCM
                     DCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRP
                     VCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKET
                     ECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENN
                     GLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQT
                     EVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKADSYVLEYRKINRDEEMI
                     SWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELVLHTPPAPVFSFLFDE
                     KCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGITKGKHFWA
                     CRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDAYFDSSQPFTL
                     VTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYDMDHMKCLYERQV
                     DCSHTMYPAFALMGSGGIQLEETITAKYLEYEEDV"
     misc_feature    323..616
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    323..616
                     /gene="Trim36"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: RING-HC_TRIM36_C-I; cd16756"
                     /db_xref="CDD:438414"
     misc_feature    692..856
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    692..856
                     /gene="Trim36"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox1_TRIM36_C-I; cd19848"
                     /db_xref="CDD:380906"
     misc_feature    869..1003
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    869..1003
                     /gene="Trim36"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 36 (TRIM36) and similar proteins;
                     Region: Bbox2_TRIM36_C-I; cd19778"
                     /db_xref="CDD:380836"
     misc_feature    1007..1381
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1007..1381
                     /gene="Trim36"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1316..1462
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1316..1462
                     /gene="Trim36"
                     /note="TRIM C-terminal subgroup One Signature domain;
                     Region: COS; pfam18568"
                     /db_xref="CDD:465805"
     misc_feature    1532..1723
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1532..1723
                     /gene="Trim36"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1787..2398
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     misc_feature    1787..2398
                     /gene="Trim36"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 36 (TRIM36); Region: SPRY_PRY_TRIM36; cd12894"
                     /db_xref="CDD:293951"
     exon            305..539
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            540..865
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1012
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1108
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1362
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1487
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1778
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2076
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..4245
                     /gene="Trim36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtccgcg cgagccgccg ccgcagccgg cagcggggcg tcattcgccg ctccctgggc
       61 cctcgcaggg agcaaccgca ctctccgcgc ccgtgctttc gcctgcgccg gccagtccct
      121 cgccgcgtgg cccgctggcc ggatctggcg gaccagcttg ccctccggtc tgacccgagg
      181 ctcccgaatc gccgcgggga ctcgcccaca cgaccctgct ggggcccgct gcgcctgtaa
      241 agactcggtg gttgatgtca cccggcggag ggctgcgatg gagggggatg cttcagactc
      301 tcaggtgact atcaagaata tcgaaaagga gcttatttgc ccagcatgca aggagctgtt
      361 tacacacccg ctgatccttc cctgccagca cagcgtctgt cataaatgtg tgaaagaact
      421 cttactgtct cttgatgact cattcaacga tgtggcgtca gacagctcta atcagagcag
      481 ccctcggctc cggctcacct cccccagcat ggataaaatc gacaagatta acagaccagg
      541 ctggaagcgt aattcactga cccccagacc aaccatgttt ccttgtcctg gctgcgagca
      601 tgatgtggat cttggagagc gaggagtcag tggtctgttt cgaaatttca ctttggaaac
      661 gattgtcgag aggtaccggc aggctgctag ggcagccaca gccattatgt gtgacctttg
      721 taaaccacca ccccaggaat ctacaaagag ctgcatggat tgtagtgcaa gctactgcaa
      781 cgaatgcttc aaaatttatc atccctgggg cacggtaaaa gcccagcatg agtatgtggg
      841 ccccaccact aatttcagac ccaagatttt aatgtgccca gaacatgaga cagagagaat
      901 aaacatgtac tgtgaactgt gcaggagacc ggtttgccac ctctgtaagt tgggtgggaa
      961 tcattccaat caccgggtaa ccaccatgag cagtgcctac aaaacattaa aggagaaact
     1021 ttcaaaagac attgatttcc ttattggtaa ggaaagccag gtgaagagtc aaatttctga
     1081 actaaacttg ttaatgaaag aaacagagtg caatggagag agggcgaagg aagaagcgct
     1141 ggcacatttt gagaagctct ttgaaatcct ggaagacagg aagtcgtctg ttctgaaagc
     1201 catagatgcc tctaagaaac taagactaga taaatttcac actcaaatgg aagagtacca
     1261 aggccttcta gagaataacg ggcttgtggg atatgctcag gaagtgctga aggagacgga
     1321 tcagtcttgc tttgtgcaga cagcaaagca gctccatctc agaatacaga aagctacaga
     1381 atccctgaag agctttagac ctgcagccca ggcttctttt gaagactatg ttgttaacat
     1441 ttcgaaacaa acagaggtgc ttggagaatt gtcctttttc tctagtggca tagacattcc
     1501 tgagatcaac gaggaacaga gtaaagtgta taataatgcc ctgatagact ggcaccatcc
     1561 agaaaaggac aaagccgaca gctatgttct cgaataccgc aagattaata gagacgaaga
     1621 aatgatatcc tggaatgaga tagaagttca tggcacaagt aaagttgtct ccaatcttga
     1681 aagcaacagt ccctatgcgt tccgagtgag agcttacagg ggttctatct gcagtccctg
     1741 cagtcgagaa ctggttctgc atactcctcc agctccagtt ttcagtttcc tgtttgatga
     1801 aaagtgtggc tacaatactg agcatctctt gctgaacctg aagagagacc gggtagaaag
     1861 cagagctgga tttaatgtcc tcctcgctgc ggaacgcatc caagtgggcc attacacaag
     1921 cttagactac atcatcgggg atgtcggaat cacgaaaggt aaacacttct gggcctgccg
     1981 tgtggaaccg tattcatacc tggtgaaagt gggagttgct tccagtgaca aactgcaaga
     2041 gtggctgcgc tctccccggg acgcagctag tccaagatat gagcaagaca gtgggcatga
     2101 cagcggaagt gaggacgcct attttgattc ttcacaaccg tttacattag ttactatagg
     2161 catgaagaaa ttttttatac ccaagtcacc tacttcttct aatgaacccg aaaacagagt
     2221 tctccccatg ccaacaagta tagggatttt ccttgactgt gataaaggca aagtgagctt
     2281 ctatgatatg gaccacatga aatgcctata tgagcgccag gtggactgtt cacacacaat
     2341 gtaccccgct tttgcgttaa tgggcagtgg cgggatccag cttgaggaaa ccatcaccgc
     2401 gaagtatctg gaatatgaag aggatgtgta gcttggacac cccacaggac gaggatcaga
     2461 actgtgaaca aagccatgcc gtggtgttag agtcttcgta actaattaca tatcatttac
     2521 gtctctgtca ccacacctgt ttgtactgtg tgattctttg ttttgttttg ttctgctttg
     2581 acacacacag tctcagtgtg tagtccaggc cagcttcaaa ctctgttctg ttatagcctc
     2641 cttaggggct gggattatag gcaggcacca ccatacccag ctagtgtatg attcacaact
     2701 tttttcatgt cataatggtc ttacctttta caaatggtgg gagtagagac ttgtcttaac
     2761 tggtccagga tagataactc tacaatggaa gtccttctct ttggggacaa ggactctaat
     2821 tgatgtaagt cagctgatgg tggtattatt cctgtccctt tgtttggggg ttgcagtggg
     2881 atacaaagta tttacaaagt tctttgtgct tgttttcttc tttccttttc attgtgtatc
     2941 atgttcatgt ccaaagagaa gatattttta aatgtttatc gatagaaatt agtactaagc
     3001 catgtgtctt gcatttgatg ttaataggaa aataaattta cagataggta aaatgatgaa
     3061 ggccataaaa tggtagtata tttaagtaga aaattatgta ttttaaagtg tgtaactact
     3121 gagtgtatat tgcctggcaa acgaatactg ctttttccct ctatagacca cagactgtat
     3181 tggtaagaat atctctaaga gtgtctttgc tgtagtgccc attgtcctgt acatgtagca
     3241 agcatcgttt catataagaa acacagggtt cttgaaccca tgcgactttc cactacaata
     3301 gaattctttt tcaggaaatt ttattttcaa attttcttat tttagaaaat actcatttat
     3361 agcaaagaat tatttttcag aaatactagg gaagatggac tgatagtgaa cacctatctt
     3421 tttgtgtctt gtgaacttta tgattttggt acatatgtta tacatcaggg ttttctggct
     3481 tttgtttaca gatttgagaa gtttgctgtc cattttcagc gttgttgaat gccagacatg
     3541 ttacatgtta ctactgtcca cttggatggc actgtttgtg ggctcattgt gtggtcataa
     3601 gcatttgtag tgtgaatcag taaaatacaa aattccttag acataatagc taaacatcac
     3661 aaggatgtgt ctagtcagtt tttacacctt ttctacacta gatgttaatt tctgcaaggt
     3721 tactttccaa ttatttgaat tgccttttta aaagttaaaa tgtccagaca ctaagactta
     3781 catgtgttca gcactgatca tgcaatggaa tggtagcatt ttggtagaat aaccaaagct
     3841 gtttatttga ttgattcttt ttaatggaag cctgttgggc taatcacact gcatctgacc
     3901 cagcactgac tggtacgcat ccctacgctt gtgtagaaat atctggagga tttgtgttta
     3961 gtgattgccc ttcctctccc acttatatct agcactttat gacataggaa acagagagaa
     4021 tgtgcagtgt tacctggggt cattgtgcaa taatgctgct aaagtcgccg cacgtgtggg
     4081 ttagtgtgac actcaatatt catgtaagca catgtcctgt agacatttta aaatataaag
     4141 ctttaactgg agtcagagaa gcgagctgtt cgaacactgt atcactgtat agaaattgct
     4201 tagtggaatt ccactttttt aaaataaaaa aataaataaa gggaa
//
LOCUS       NM_001437464            2775 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus MISP family member 3 (Misp3), transcript variant
            1, mRNA.
ACCESSION   NM_001437464 XM_006255249
VERSION     NM_001437464.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006255249.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.35838.1,
                                           SRR26643288.60977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2422              JAXUCZ010000019.1  41043408-41045829
            2423-2496           JAXUCZ010000019.1  41046193-41046266
            2497-2775           JAXUCZ010000019.1  41046483-41046761
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2775
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="MISP family member 3"
                     /db_xref="GeneID:304650"
                     /db_xref="RGD:1310262"
     exon            1..2422
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1726..1728
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="upstream in-frame stop codon"
     CDS             1879..2511
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /codon_start=1
                     /product="uncharacterized protein MISP3"
                     /protein_id="NP_001424393.1"
                     /db_xref="GeneID:304650"
                     /db_xref="RGD:1310262"
                     /translation="METPIQREIRRSCEREESLRRSRGLSPGRAGEELIELRVRPVLS
                     RPGSGIPLPRALERARAGAKMQRDIEREAHRQAALASPAVPEPSARPRPQPLDELKRF
                     FEAAAEDGASLQRQPEAGGRLHPALQDGCPVLGQLPPLVAPSLLEQEVLRVREREREL
                     QLQRRSIYGAAEDREPAPSLTQSRGDGKLAVTWPPRRQASENGLEKERRP"
     misc_feature    1987..2478
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="A-kinase anchor protein 2 C-terminus; Region:
                     AKAP2_C; pfam15304"
                     /db_xref="CDD:464630"
     misc_feature    1987..2478
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /note="A-kinase anchor protein 2 C-terminus; Region:
                     AKAP2_C; pfam15304"
                     /db_xref="CDD:464630"
     exon            2423..2496
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2775
                     /gene="Misp3"
                     /gene_synonym="RGD1310262"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaagatgta tttattttta ttttatgtgt atctgtggtg tgctgcatat gttgggacag
       61 tgcctggggg gttgggggag tcaggttcca taaggctgga gttaccgata gggtgaacta
      121 tcctggtccc ctggaagagc agtcagtgct cttaactcat gaaccacctc tccaacccaa
      181 gagaaggcac cgtttgagac tgggtgtaag aggaggacag agagaaaagg gtgaccaaat
      241 agttgggatt ttgtgcccct ctatttccac ttctttcttt gtttggtgaa gtaagacctg
      301 gaaatgtagc cctgggtgtc ctggatctca ctgcatagaa caggcactcc cctccaatca
      361 tggagacccc tctgcctctg cctcctgagt gctggggtta aaggcttgtg cctccaccct
      421 tattcctctt tccattttct ttaggtaatt gtctttctcc caggttacta tagaatgaca
      481 cggggtgggc cggtttttgt gaaagttgtc ttccacaagg ggcagtggaa aaagtttctg
      541 ccctcactct gaacccttga ccctatcctg gaagacaacg gagcagcaaa ggtcgctact
      601 gcctcccgcg aaccccgtat ctcttctgcc ccagcctggg cctcctaagc aacctggccc
      661 aagctgaccg tcttccgtcc gcaattgctc atctagggcc cggaagtctt gtagtgcctg
      721 ggctctcaac cctcgctcat tctagctgga cacttggctg ccaacgcctt gtgggctttt
      781 ttggaaggtg gtggtgctgg gggagctgct ccagggcttt gagcggcagc agtggggctg
      841 caaacccagg cagagctaag caacccagag cagcaggagc aggcattggg gtgcccccgg
      901 gtgcccccac gggctgaacc cgagctgtgc tgcagcagcg atttgtgtgc agagaagacc
      961 gggagaccac agggggggta aggggggcca tgtcgctggc cgcgggctgg cacctgctga
     1021 gctagactag tgaggtcagc gaaagacgac cggggaaaca ctctgtaagg aggccatgga
     1081 cagcgatcag cacggcgctc cactagaggt cagatctcca gaaagtgata aaaaaacgag
     1141 accccaaaaa tgccagcgtg gtaccagagg gaaagggcga cacatacccc cttgggtaga
     1201 gttcagggaa gccctttctg aagaaaacgt cccttcagtc aacccgtggg ttcaggtggc
     1261 gggaatccgg cgtccagcct aggcgccctg gccatagggc gggtccaggg ccactggaat
     1321 ccagctggca ggtgccgggg gcggtgccca gtcctgcccc caggggacct tcctggaggc
     1381 cagaggcggg tcaaagaaga gtgctggcga cgccttagaa cctcgggcgg cggctgcaac
     1441 cacaggtacg gcgcagggca ttgtgtccta cctatctggg catcttaatc cggctctgag
     1501 aactgaaatt gtcaaagtgc gcctaactcc gaacatccat gcccccgggt gtccgagagc
     1561 ggagtcctgg gatcgcctga aacttaaagc tacgtgttcc gggagccgca gagccagggc
     1621 accgagggct gcagggggag gtagtgaggt cctgaaaacc tctggagagg aggacttgga
     1681 gaccccgggg ccatagccag gtcccgcaag tgccagtgga gcaggtgact gagcgcccgg
     1741 gcggtccgcg tctgggtcgc ctggcacttg gataacggag gtactgggac agttgtgccc
     1801 ctgcgtcggc tcagaggcct ccaggtgtgt tttccaccga ggcccgtggc atccaaacca
     1861 gcgcctgcgg aactgctgat ggagacgccc atccagcgcg aaatccgccg tagctgcgag
     1921 cgcgaggaga gcctgcgccg gagccgcggt ctgagtccgg gtcgcgcggg agaggaactc
     1981 atcgagttgc gggtgcggcc ggtgctcagc cggccaggtt ccggtatccc gctgccgcgc
     2041 gccctggagc gcgctcgggc gggcgcgaag atgcaacggg acatcgaacg cgaggctcac
     2101 aggcaggcgg cgctggcgag ccccgcggtt ccggagccca gcgcccggcc gcggccgcag
     2161 ccgctggatg aactcaagcg cttctttgag gctgcggcag aggacggagc gagcttgcag
     2221 cggcagccgg aggccggagg ccggttgcac cccgcccttc aggacggctg tccggtactg
     2281 gggcagttgc cgccgctcgt tgctccgtca ctgctagagc aggaggtgct ccgggtgcgt
     2341 gagcgcgagc gggagctgca gctgcagcgg cgcagcatct acggggcagc cgaggaccgg
     2401 gagccagcgc cgagcctcac ccagagcagg ggagatggaa agttggcggt gacctggccc
     2461 ccgcggagac aggcctcaga gaacggcctg gagaaggagc gcagaccctg aggtctgtga
     2521 aggttggggc ctgcggccag aagtaacatg ccctttggag aaccagggta gggttatcct
     2581 ccagatcagc agaaggccta gagagggaag gcccagcttt ctttaatgga aacttgaaat
     2641 tcagcccatc cctgatactg actatggaat taaccacctc tctccataaa agtgtttagt
     2701 cttccctgga aaatagacca ccgcccgcaa aacctgagtg aaacatacaa taaagttctc
     2761 ctcccttttc ctggg
//
LOCUS       NM_001437551            5089 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus PPARG related coactivator 1 (Pprc1), transcript
            variant 3, mRNA.
ACCESSION   NM_001437551 XM_006231453
VERSION     NM_001437551.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5089)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006231453.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.5552.1,
                                           SRR26643429.5846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000001.1  254851189-254851370
            183-356             JAXUCZ010000001.1  254856186-254856359
            357-503             JAXUCZ010000001.1  254856944-254857090
            504-605             JAXUCZ010000001.1  254857203-254857304
            606-3462            JAXUCZ010000001.1  254857400-254860256
            3463-3516           JAXUCZ010000001.1  254860529-254860582
            3517-3574           JAXUCZ010000001.1  254861917-254861974
            3575-3642           JAXUCZ010000001.1  254862695-254862762
            3643-4360           JAXUCZ010000001.1  254863590-254864307
            4361-4498           JAXUCZ010000001.1  254865878-254866015
            4499-4565           JAXUCZ010000001.1  254866108-254866174
            4566-4687           JAXUCZ010000001.1  254866293-254866414
            4688-4839           JAXUCZ010000001.1  254866843-254866994
            4840-5089           JAXUCZ010000001.1  254867210-254867459
FEATURES             Location/Qualifiers
     source          1..5089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5089
                     /gene="Pprc1"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
     exon            1..182
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4943
                     /gene="Pprc1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1; peroxisome proliferative
                     activated receptor, gamma, coactivator-related 1;
                     peroxisome proliferator-activated receptor gamma,
                     coactivator-related 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 3"
                     /protein_id="NP_001424480.1"
                     /db_xref="GeneID:294007"
                     /db_xref="RGD:1309688"
                     /translation="MAARRGRRDRVAPPPTGGPGPDPGGGVRGGGWASRSQAPHGTVG
                     SVSPAEQVHEEGDDSSFVSLSRLGPSLREKDLEMEELILQDETLLETMQNYMDASLIS
                     LIEDFGESRLSLEDQNEMSLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLH
                     KLLNLSRTPPERDRIPAMDPLGPSAGSSRVSGVEMSLADSPWDFSPPPFLETSSPKLP
                     SWRSSRPRPRWSQSPPPQQRSDGEEEEEVAGFSGQMLDGELDNSVNTLDFPMHLACPE
                     EEDKSGAANVAVSAPGDESISSLSELVRAMHPYCLPNLTQLASLDAELQEQADDLTLP
                     EGCVVLEIVGQAATAGDDLEIPVVVRQIPSGSQSVLLDGSVGTDPALQLLMPAMEPGT
                     EDGVPKVAPCPDQELPLSSACLLEPRDIMESLAPKEPRNLPANASEGSQRVPRKGRKK
                     KKKEQPTACLEGCTRRLRSSSRGQSTVATEVNSQAGNLQKQPQEELQRETAAPQSRGK
                     PRAWARAWAAALEKTGSEDPEDQNAGQDSPAEEDVLELRPKLVETSQADPTLSLNDSA
                     RADSIPVNSVEGDSTAVDTAVPVDQASSCTELVGSLSGGPILSSPVLDDRTGVEPAVA
                     IPTSNHLSPADAILANPGTADPAPNGLAPGDPVLVKCRPTDPRRAAAAATAAQGPRPS
                     LEPSDHPKVITPEVKDAGGPLKVEGSTSATTQEARPRPLSLSEYRQRRRQRQIEAEDR
                     NSQPPAGKWPSLPETPKGLADIPCLVPSAPTKKTAPQRSPIAVPETCSVSVGSNPVSP
                     TPEPSASKLMVSTHSEQVSSHEMPLPVRLPPPTLQSMAPAGPTPSTVPTPLPFPPSLP
                     PLLPLPASGPGVPSLPPPPLQPPGLPVSMRQMPPDPYTQYAPVPPWPCYPSVSPSGYS
                     CLPPPPAMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSSAYGSLGWGPGLQQPPF
                     WSTVSPPPLSSASTGRAVPPPSVEPSNSSAGPPEDTLPVPVTPSLSSRPASPIAPPAE
                     PTKLEAQPVPVSPQPKHKVSPVVQSPQIKVLPTLSAEGVAIGESESERLKPETQENRP
                     REKPISTATKAVLLPKQSTVAKLPAVHPARLRRLSFLPTPRAQGSEDVVQAFISEIGI
                     EASDLSSLLEQFEKSEAKKECPLPAPADSVAVGNSGIDTPQEKKPLDRLHAPELANVA
                     GLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPAAACLQEGVR
                     GPSPVHVGSGDHDYCVRSRTPPKKMPALVISEMGSRWNVKRHQDITIKPVLSLGSAAP
                     PLPCTTTSQEPLDHRTSSEQADPSAPCFAPSTLLSPEASPCRNEMNTRTPSEPPDKQR
                     SMRCYRKACRSASPPSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSLS
                     PPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSRSRSPSVSPCRRSDRRRRYSSY
                     RSNDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQ
                     GDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDF
                     DPAPVKSKFDSLDFDTLLKQAQKNLRR"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1161..2558
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1917..3374
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4109
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2958..4109
                     /gene="Pprc1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    4569..4841
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     misc_feature    4569..4841
                     /gene="Pprc1"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator-related
                     protein 1 (PRC) and similar proteins; Region: RRM_PRC;
                     cd12624"
                     /db_xref="CDD:410035"
     exon            183..356
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..503
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3462
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3516
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3574
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3642
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..4360
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4498
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4565
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4566..4687
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4839
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..5089
                     /gene="Pprc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagaccgag
       61 tcgcgccgcc tccgactggg ggcccgggtc ctgaccctgg cggtggagtg cgcggcggcg
      121 gttgggcgag tcgaagtcaa gcgccgcatg ggaccgtggg ctccgtgagc ccggcggagc
      181 aggtccatga ggaaggagat gactctagct ttgtcagtct ttctcgactg ggcccatctc
      241 taagggagaa agacctggaa atggaggaac tgatactgca ggatgagaca ctactagaga
      301 ccatgcagaa ctacatggac gcctccctta tatccctcat tgaggatttt ggagagagca
      361 ggctatcttt ggaggaccag aatgagatgt cgctgctcac agctctgacg gagatcttgg
      421 acaatgcaga ttctgagaac ctgtccccgt ttgataccat tcctgattca gagctgctcg
      481 tgtctcctcg ggagagctcc tctctgcaca agctgctcaa tctctctcgg acacctccag
      541 aacgtgaccg catccccgca atggaccctt tggggcccag cgcaggaagt agtcgggtga
      601 gtggggttga gatgtccctt gcagattctc cgtgggactt ctctccacct cctttcttgg
      661 aaacttcttc ccctaagctg cctagctgga gatcctcaag accaagacct cgatggagtc
      721 agtctcctcc tccccagcag cgcagtgatg gagaggagga ggaagaggtt gccggcttca
      781 gtggtcagat gcttgatggc gaacttgaca actcggtgaa taccttggat ttccccatgc
      841 acctggcatg ccctgaggaa gaagacaagt caggggcagc aaatgtggca gtgtcagcac
      901 ctggtgacga gagcatctcc tccttgagtg agctggtacg ggccatgcac ccctactgct
      961 tacccaacct cacccagttg gcatcacttg acgctgagct tcaggagcag gctgatgatc
     1021 tgacactgcc tgagggttgt gtggtgctgg agattgtggg ccaggcagcc acagctggtg
     1081 atgacctgga gatcccagtg gtcgtgcggc agattccttc aggatcccag tctgtgctcc
     1141 tagatgggtc tgtagggact gatcctgcct tgcagctact catgcccgcc atggagcctg
     1201 gaacagaaga tggtgtgcct aaagtcgctc cttgccctga tcaagaatta ccactgagct
     1261 ctgcctgctt attggagccc agggacatca tggagtcatt ggcccccaag gagcctcgga
     1321 acctacctgc caatgcaagt gagggttctc agagagttcc cagaaagggt aggaagaaga
     1381 agaagaagga gcagccaaca gcctgtttgg aaggctgtac caggaggctg aggtcatctt
     1441 ctcgtggaca gtctactgtg gctacagagg tgaactctca ggcaggcaac ttacagaaac
     1501 agcctcagga agagcttcag agagagactg cggcccctca gagcagaggg aagccacggg
     1561 cttgggctcg ggcctgggca gctgccttgg agaaaactgg gtctgaagac ccagaggacc
     1621 agaatgcagg acaggatagt cctgctgagg aagatgttct agaactccgt cctaagctgg
     1681 tggagactag ccaagccgac cccacgctct cactaaacga ctctgctcga gctgactcca
     1741 tcccagttaa ctctgttgaa ggtgactcca ctgcagtgga cactgctgta cctgttgacc
     1801 aggcttcatc ttgtacagag ctggttggtt ctctctcagg aggcccaatt ctgagtagcc
     1861 cagtcctaga tgacaggaca ggagttgaac ctgcagtggc tattcccact tcaaatcact
     1921 tgtctccagc tgatgctatc ctagctaacc cagggacagc tgaccctgct ccaaatggcc
     1981 tggctccagg agatcctgtg ctagttaagt gcagaccaac tgatcctaga cgtgcagctg
     2041 ctgctgccac tgctgctcag gggcctcgtc cttccctaga gccctcagac catcctaagg
     2101 tcatcacccc tgaagtcaag gatgctggag gtcctctgaa ggtggaaggt agtaccagtg
     2161 ctacaaccca ggaagccaga cctcggcccc tcagcctatc tgagtaccgt caacgacggc
     2221 ggcaacggca aatagaagca gaagacagga attctcagcc cccagctgga aagtggccaa
     2281 gtctcccaga gacgcccaaa gggctggcag atatcccttg tcttgttcca tcagccccaa
     2341 ccaagaagac agccccacag agaagcccta tagctgtacc agagacttgt tctgtatctg
     2401 tgggttctaa ccctgtttcc cctactcctg agccatctgc aagcaaactt atggtttcaa
     2461 ctcactctga acaggtgtca tctcatgaga tgccacttcc agttagactt ccccctccta
     2521 cattgcagtc tatggctcct gctgggccca ccccttctac agtgcccacg ccattgcctt
     2581 tccctccgag cttacctcct ctgcttcctc ttcctgcaag tggtcctggt gtccccagcc
     2641 tgcccccacc tcctttgcaa cctcctggac ttccagtatc aatgagacaa atgccacctg
     2701 acccctatac tcagtatgcc cctgtgccgc cctggccttg ttacccctct gtatctcctt
     2761 ctggctattc ttgtctgccc ccaccaccag cgatgcccat agtgtcgggt acccctggta
     2821 cctatgctgt acccccaact tgcaatgtgc cttgggtacc ccctcctgca ccagtctcac
     2881 cttatagctc cagctctgcc tatgggtccc ttgggtgggg cccagggttg caacagcctc
     2941 ccttttggtc tactgtttct ccacctccat tgtcttcagc ctctactggt agagctgttc
     3001 ccccacccag tgtggaaccc agtaacagtt cagctggtcc tccggaagat acacttcctg
     3061 tgccagtgac cccttccctg agctctcggc cagccagccc catagctcca ccagcagaac
     3121 ctacgaagct ggaggctcag ccagtgcctg tctctcccca accgaaacac aaagtgtccc
     3181 ctgtggtaca gagtccccag atcaaggttc taccaactct gtctgctgag ggcgtggcta
     3241 ttggggaatc tgaatcagag aggctaaagc cggagaccca ggagaacaga ccaagggaga
     3301 agcctatctc tacggctacg aaggctgttc tgttaccaaa gcagagcact gtcgcaaaac
     3361 tgcctgccgt ccatccagcc cggctaagga ggctgtcctt cctgcccacc ccacgtgctc
     3421 agggttctga ggatgtggtg caggcattca tcagtgagat tgggattgaa gcatcagacc
     3481 tgtccagtct gttggagcag tttgagaaat cagaagccaa aaaggagtgt cctctcccgg
     3541 ctcctgctga cagcgtggct gtaggaaact caggcattga cactccccag gagaagaaac
     3601 ccctagaccg gttacacgcc ccagaactgg ccaacgtggc agggctcacc ccgccagcta
     3661 cccctcccca ccagttatgg aaacccctgg ctgctgtctc actgttggcc aaagccaaat
     3721 ctcctaaatc tactgcccaa gagggaaccc tgaagcctga aggaattaca gaggccaaac
     3781 ctccagctgc agcctgcctc caagaagggg tccgtggccc tagtccagtc catgtgggct
     3841 ctggggacca tgactattgt gtccgaagca ggacaccccc aaaaaagatg cctgccctag
     3901 tcatttcaga gatgggctct cgatggaatg tcaagcgcca tcaggacatc actatcaaac
     3961 ctgtcttgtc attgggctca gctgcccccc cactcccatg cacaaccact tcccaggaac
     4021 cgcttgatca caggactagc agtgagcagg cagatccgtc agcgccttgt tttgccccat
     4081 ccaccttgct gtctcctgag gcctcaccct gccggaatga aatgaacact aggactccct
     4141 ctgagccccc agacaagcag cggtcaatgc gctgttaccg aaaagcctgc agatcagcca
     4201 gccccccaag tcggggctgg caaggccgcc gtggccgtag cagccgttct gtcagctctg
     4261 ggtccagccg gaccagtgaa gcatcctcat cctcatcggt gtcttcctca tcccggtccc
     4321 ggtccaggtc cctctccccc ccaaacaaga ggtggcgaag gtccagctgc agttcctctg
     4381 gacggtccag aagatgttcc tcctcttcct cttcttcctc ctcctcatct tcatcatcca
     4441 gttccagaag ccggtctccc tctgtgtccc cttgcaggag aagtgaccgg aggcggcggt
     4501 acagctctta ccgttcaaat gaccattacc aaaggcagag agtactgcag aaggagcgtg
     4561 caatagaaga gagaagggtg gtcttcattg ggaaaatacc tggccgcatg actcggtcgg
     4621 agctgaagca gaggttctct gtttttggag agattgagga gtgtaccatt cattttcgtg
     4681 tccaaggtga caactatggt ttcgtcactt accggtatgc tgaagaggca tttgcagcca
     4741 ttgagagtgg ccacaagttg cggcaggcag acgagcagcc ctttgatctc tgctttgggg
     4801 gccgaaggca gttctgcaag aggagttact ctgatcttga ctccaatcgg gaagactttg
     4861 atcctgctcc tgtcaagagc aaattcgatt ctcttgactt tgatactttg ttgaaacagg
     4921 cccagaagaa cctaaggagg taaccctggg ctttcctccc ccatccattt tctctggagg
     4981 tgtccaacct ctcaaccccc tcccctactc taggggagag agctgctagt gtggaaagac
     5041 ttttataagg aaatgaaaaa aagttaaata aaaatatgtt aaatcggga
//
LOCUS       NM_001437425            2065 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus polo-like kinase 5 (Plk5), transcript variant 2,
            mRNA.
ACCESSION   NM_001437425 XM_006240922
VERSION     NM_001437425.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006240922.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38033.1,
                                           SRR26643294.27580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000007.1  10005661-10005843   c
            184-291             JAXUCZ010000007.1  10004242-10004349   c
            292-408             JAXUCZ010000007.1  10003992-10004108   c
            409-538             JAXUCZ010000007.1  10003456-10003585   c
            539-626             JAXUCZ010000007.1  10002630-10002717   c
            627-722             JAXUCZ010000007.1  10002452-10002547   c
            723-921             JAXUCZ010000007.1  10001658-10001856   c
            922-1048            JAXUCZ010000007.1  10001445-10001571   c
            1049-1125           JAXUCZ010000007.1  10001180-10001256   c
            1126-1198           JAXUCZ010000007.1  10000771-10000843   c
            1199-1276           JAXUCZ010000007.1  10000493-10000570   c
            1277-1433           JAXUCZ010000007.1  9999984-10000140    c
            1434-1563           JAXUCZ010000007.1  9998944-9999073     c
            1564-1674           JAXUCZ010000007.1  9998755-9998865     c
            1675-2065           JAXUCZ010000007.1  9997453-9997843     c
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2065
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polo-like kinase 5"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
     exon            1..183
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1866
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /EC_number="2.7.11.21"
                     /note="isoform 2 is encoded by transcript variant 2;
                     polo-like kinase 5 pseudogene; serine/threonine-protein
                     kinase PLK5; inactive serine/threonine-protein kinase
                     PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5
                     isoform 2"
                     /protein_id="NP_001424354.1"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
                     /translation="MEPRLRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLHHRNIVAFHAHFADRDHVYM
                     VLEYCSRQSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYLHQQRIVHRDLKPSNFFLNK
                     NMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSAKSDIWALGCIMYTV
                     LTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIARLLAPDPDERPSLDHLLQD
                     DFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQLLLTQCRPPCPFTSKEASGP
                     GEESTEPDHMEASNEEGAPLCTESRIHLLTLGTPRTDPADAKGTLALQLEVATRKLCL
                     CLDAGPVAGQDPPGEQRSVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPP
                     GGHVSYQPDQGTLWIFALRDVPGPLRAKLAVLRLFACYMQRRLREEGTAPMTATPASP
                     DFCLLSFTADAQALAMLFSNGTVQVSSKTSPVQLVLSGEGEDFLLTIQEPGGPSMGTS
                     YTLDVLRSHGISLAVRHHLRLGLHLLQSV"
     misc_feature    151..915
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Polo-like kinases; Region: STKc_PLK; cd14099"
                     /db_xref="CDD:271001"
     misc_feature    151..915
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Polo-like kinases; Region: STKc_PLK; cd14099"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     388..399,409..411,415..417,526..528,532..534,538..543,
                     547..549,580..582,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="active site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     388..399,409..411,415..417,526..528,532..534,538..543,
                     547..549,580..582,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="active site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     391..399,547..549,580..582)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(175..189,199..201,238..240,244..246,340..342,
                     391..399,547..549,580..582)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(187..189,409..411,415..417,526..528,532..534,
                     538..540,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(187..189,409..411,415..417,526..528,532..534,
                     538..540,589..591,637..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271001"
     misc_feature    order(577..603,616..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271001"
     misc_feature    order(577..603,616..648)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271001"
     misc_feature    1306..1569
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    1306..1569
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="First polo-box domain (PBD) of polo-like kinases
                     Plk1, Plk2, Plk3, and Plk5; Region: POLO_box_1; cd13118"
                     /db_xref="CDD:240561"
     misc_feature    order(1324..1335,1540..1542,1546..1560)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     misc_feature    order(1324..1335,1540..1542,1546..1560)
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:240561"
     exon            184..291
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            292..408
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            409..538
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            539..626
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            627..722
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            723..921
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1048
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1125
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1198
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1276
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1433
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1563
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1674
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..2065
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcggcag cgctgcaggc agcactggct tgcccagttc ccgcgcgcgc gctgcgcacc
       61 caggcccacc ccgcgtcgat ggagccccgg ttgaggcggc ggcgaagccg ccagctagtg
      121 gccaccttcc tgcgtgaccc gggctcaggg cgcgtgtacc ggcgcgggaa gctgatcggc
      181 aagggcgcct tcagccgctg ctacaagctc acggacatgt ccaccagcgc ggtgtttgct
      241 cttaaggtgg tgccgagggg cggagcgggg cggctgcgcc tgcgcgggaa ggtggagcgt
      301 gagatcgccc tgcacagccg cctgcaccac cgcaacatcg tggccttcca cgcacacttt
      361 gctgaccgcg accacgtgta tatggtgctg gagtactgta gccgccagtc cttggctcat
      421 gtactgaaag tgcggcggac cctgacggag cctgaagtgc gctactactt tcggggcctg
      481 gtcagtggcc tccgctacct gcaccaacaa cgcatcgtgc acagggacct gaaacccagt
      541 aatttcttcc ttaacaagaa catggaagtt aagataggtg acctggggct ggctgcccgt
      601 gtggggcccg ctggccgctg ccacagggtg ctctgtggga ctccgaactt ccaggctcct
      661 gaagtggtgt cccgaaatgg acactcggcc aagtctgaca tctgggccct ggggtgcatt
      721 atgtacacgg tgctgacggg cacgcccccc ttcgctgccg cacccttgtc cgagatgtac
      781 caaaacatcc gagacggtca ctaccttgag cccactcagc tgtcacccag cgcccgtagc
      841 ctcattgcac gacttctggc accggaccct gatgagcggc ccagcctgga ccacttactg
      901 caagatgact tttttagtca gggctttacc ccagagcggc tgcctccaca ttcctgccac
      961 agcccacccg tgtttgcctt ccccccgcca ctgggcaggt tgttccggaa ggtgggccaa
     1021 ctcctgctga cccagtgccg gccgccctgt ccctttacct caaaagaggc ctcaggcccg
     1081 ggagaagaga gtacagaacc tgaccacatg gaggccagca acgaggaagg ggctcctctc
     1141 tgcactgaga gccgaatcca cctcctcact cttggaaccc ctcggactga cccggccgat
     1201 gcgaagggga ccttggccct gcagctggag gtggcaacca gaaaactgtg cctctgcttg
     1261 gatgcaggac ctgtggctgg acaggacccc cccggggagc agcgctctgt cctctgggct
     1321 cccaagtggg tggattattc cctcaagtat ggcttcggtt accagctgtc ggatgggggc
     1381 agtggcgtgc tgtttcggga tggctcccac atggccctgc gccccccagg aggccatgtc
     1441 tcctaccaac ctgaccaagg gactctgtgg atcttcgccc tgagggacgt ccccggccca
     1501 ctccgcgcca agctggccgt cctgaggctc tttgcctgct acatgcagcg gcgtctgcgg
     1561 gaggagggga cagcacccat gacggccaca cccgcctctc ctgacttctg tctgctgagc
     1621 ttcaccgctg atgcccaagc tctggccatg ctctttagca atgggacagt gcaggtcagt
     1681 tccaaaacct ccccagtcca gctggtgctg agtggggaag gcgaggactt tctgctcacc
     1741 atccaggagc cagggggacc cagcatgggc acctcctaca cgctggacgt cctgcggagt
     1801 cacggcatca gccttgcggt ccgccaccac ctgcgccttg gactgcatct gcttcagagt
     1861 gtctaaggag ccggacggag atctgggcgg acctctgcgt gatggtgctg gtgtctgttt
     1921 ctgtctgcgc tcctccgcca cagccagtgt ctgtggaggg tggacacatt gggacctctg
     1981 atgggtgggc gtctttgatt atttgactac tcaaggtaga ctttttttgg attttcatta
     2041 aagaaaacag aaccctttaa actgc
//
LOCUS       NM_001106348            1431 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus melan-A (Mlana), transcript variant 1, mRNA.
ACCESSION   NM_001106348 XM_001079637 XM_215234
VERSION     NM_001106348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Hoashi,T., Watabe,H., Muller,J., Yamaguchi,Y., Vieira,W.D. and
            Hearing,V.J.
  TITLE     MART-1 is required for the function of the melanosomal matrix
            protein PMEL17/GP100 and the maturation of melanosomes
  JOURNAL   J Biol Chem 280 (14), 14006-14016 (2005)
   PUBMED   15695812
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   De Maziere,A.M., Muehlethaler,K., van Donselaar,E., Salvi,S.,
            Davoust,J., Cerottini,J.C., Levy,F., Slot,J.W. and Rimoldi,D.
  TITLE     The melanocytic protein Melan-A/MART-1 has a subcellular
            localization distinct from typical melanosomal proteins
  JOURNAL   Traffic 3 (9), 678-693 (2002)
   PUBMED   12191019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001106348.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO783755.1, BG378791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000001.1  236883220-236883249
            31-126              JAXUCZ010000001.1  236885207-236885302
            127-223             JAXUCZ010000001.1  236889688-236889784
            224-337             JAXUCZ010000001.1  236895205-236895318
            338-1431            JAXUCZ010000001.1  236896600-236897693
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1431
                     /gene="Mlana"
                     /note="melan-A"
                     /db_xref="GeneID:293890"
                     /db_xref="RGD:1306525"
     exon            1..30
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            31..126
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Mlana"
                     /note="upstream in-frame stop codon"
     CDS             56..406
                     /gene="Mlana"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanoma antigen recognized by T-cells 1"
                     /codon_start=1
                     /product="melanoma antigen recognized by T-cells 1 isoform
                     1"
                     /protein_id="NP_001099818.1"
                     /db_xref="GeneID:293890"
                     /db_xref="RGD:1306525"
                     /translation="MPREEVHFGYPRKGHSHSYITAEEAAGIGILVVALGIALLIGCW
                     YCRRRSGYRALTDKRRHAGTQNTSRERCLCESLDHQDSRLSSQEKNHQPVVPNAPPAY
                     EKLSSDHSPPPYSP"
     misc_feature    59..403
                     /gene="Mlana"
                     /note="Protein melan-A; Region: MLANA; pfam14991"
                     /db_xref="CDD:464426"
     misc_feature    59..403
                     /gene="Mlana"
                     /note="Protein melan-A; Region: MLANA; pfam14991"
                     /db_xref="CDD:464426"
     exon            127..223
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            224..337
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
     exon            338..1431
                     /gene="Mlana"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagcaggg aggactgctc ctcaaggaag gtgtcctgtg ctctgagttc acacaatgcc
       61 ccgagaagaa gttcacttcg gttatcccag gaaggggcac agccactctt atatcactgc
      121 tgaagaggcc gcagggattg gcatcctggt tgtagccctg gggattgctc tgctaatcgg
      181 ctgctggtat tgcagaagac gaagtggata cagagccttg acggacaaaa ggcgtcatgc
      241 tggtactcaa aatacctcca gggaaagatg cttatgtgag agtcttgatc accaagacag
      301 ccgactgtct tctcaagaaa aaaaccacca acctgtggtt cccaacgctc cacctgccta
      361 tgagaagctc tcttcagacc actcgccacc accatattca ccctgagagc cgagaagctg
      421 ctaagaattc tgaaagtttc cttcatgctt tcgctttaag gctgagtaga tgcccatgtt
      481 ttgctttaga atgctataga atgtacagct atactaacag gccagggtta aattcttggc
      541 agggcaagca gaagggtggc gaggaatggt gagaaatatt aaccttggaa aagcgtcaat
      601 aaatatctca acgtatatta tctgtcccag tggcaatgcc attaaatcat cattgttagc
      661 attgttttga ggggtgaact cacctggatg accagggagc ctctgatttg caaagaaatt
      721 tttatcttta tgtgtgccca catttatgta tgtgcatttg catgctgatt cctgctgaag
      781 ccggaaactg ttagattccc tggagtcgga gttacaggag gctttgagct gcctcctgtg
      841 cgtgccggaa ctaaatgagt tctctgaagg agcagggagc acttttaaca atgcagccac
      901 ctcttctgac tttctcctgc ttcctaaaat gaaacgcagc tagctttcaa actactcttc
      961 agcttttaaa agcaacctat tggccagtgt gagctgtgca gaattgccac agatgttatg
     1021 ggctgttcag aaaggatccc gttacaggtt taaaacaact tgcttctgct ggacaatgtt
     1081 aaccacggtg ctctgtgttc taaagggatc ccacagtaac acattgtaaa gtttctctct
     1141 ctctcctccc tccacttctc tctctccgtg gttatgtatt tgtgaggact gaggtcagtg
     1201 ttgggtaggt ttttttgaca gtctctcagc aaaccctgag ttcattggtt tggctaatcg
     1261 gccagggagc ctcaaatacc cacccgtgtc cactgctcag ttctggagtt aatgtgcttc
     1321 cacaccttac cattatgcgt ggactctggg gttccaaagt ctcaagctcg tgtggcaggc
     1381 atcttacaaa ctaagcgatc ttctcagcag aaaataaaat gaacaaatat a
//
LOCUS       NM_001437410            3239 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus Xrcc1 N-terminal domain containing 1 (Xndc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001437410 XM_006229904
VERSION     NM_001437410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3239)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229904.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.871264.1,
                                           SRR26360194.979097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               JAXUCZ010000001.1  165852282-165852716
            436-610             JAXUCZ010000001.1  165857557-165857731
            611-752             JAXUCZ010000001.1  165859584-165859725
            753-908             JAXUCZ010000001.1  165862675-165862830
            909-1087            JAXUCZ010000001.1  165864598-165864776
            1088-1173           JAXUCZ010000001.1  165866964-165867049
            1174-1346           JAXUCZ010000001.1  165867251-165867423
            1347-1422           JAXUCZ010000001.1  165869240-165869315
            1423-1553           JAXUCZ010000001.1  165870275-165870405
            1554-3239           JAXUCZ010000001.1  165870906-165872591
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3239
                     /gene="Xndc1"
                     /note="Xrcc1 N-terminal domain containing 1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
     exon            1..435
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..610
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    545..547
                     /gene="Xndc1"
                     /note="upstream in-frame stop codon"
     CDS             566..1789
                     /gene="Xndc1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     transient receptor potential channel 2-like"
                     /codon_start=1
                     /product="putative short transient receptor potential
                     channel 2-like protein isoform 1"
                     /protein_id="NP_001424339.1"
                     /db_xref="GeneID:102549471"
                     /db_xref="RGD:7692537"
                     /translation="MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQ
                     LKVEFQLERAVPISYIDVGNCGCAFLQIDVGRSSWPLDRPFVTLLPATMLMSLTDSKE
                     GKNRSGVRMFKDDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDP
                     VKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQL
                     QPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRG
                     KRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSI
                     EALPRHAATCGESSPPQPASPTSLSSSESVLWVSSPESSPPPSSWVQCPICELQFSAR
                     EIEEHASVCGEVFPA"
     misc_feature    566..1015
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     misc_feature    566..1015
                     /gene="Xndc1"
                     /note="XRCC1 N terminal domain; Region: XRCC1_N;
                     pfam01834"
                     /db_xref="CDD:460356"
     exon            611..752
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..908
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1087
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1173
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1346
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1422
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1553
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..3239
                     /gene="Xndc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgacc cggaaattta aataccactt gctaagggag gactgtagag cgtgaaaata
       61 tatattaaaa actcctgaac gtggggtttt gttgttttgt ttttagatgt aggatctgct
      121 gtacttcctc agtagaagtc atctttcaga aatagcggct tctttaggac tcaaaatccg
      181 ttttgggcta cagtgggaag gctagaaagg ggaggtcacg ggacggaatt ggcgggagaa
      241 taagatctga gcaccgaaac tgaagctact acgacatgaa gtttatggac gcgggtgaga
      301 agggttggga tttgtcctct ggagaggaat agctgaaagg gaagagggtg gccaacaaga
      361 aaatgaacag agcacccggt ttcggggtct taatcctcag agagactgag agctgaagaa
      421 ccaaatggga cctcagagta atgtaaggac tcttcttctt ccaaaagcta ccaagagcaa
      481 aacatagacc gtgtcaccgt ggttacagaa gacatcctgg gaggaagcat atctgcctcg
      541 caaataaaga agctggtggc ctccgatggc tcctgtgaag atcagccatg tggtgtcatt
      601 ttcctctcag gatcccaaat atcctgtgga gaacttgctg aacccagaca gtcataaggg
      661 accttggctc agctgccctc gggacaagac tgggcaactg aaagtggagt ttcagctgga
      721 gagagcagtg cccataagct acatcgatgt cggtaactgt ggctgtgctt ttctacagat
      781 tgacgtgggt cgttcttctt ggcccctgga cagacctttt gtcaccctgc tccctgcaac
      841 catgctcatg tccctcactg actcaaagga ggggaagaac cgctcagggg tccggatgtt
      901 taaagatgat gattttctga ttccagcctc aggagaatca tgggatcgac ttcgattgac
      961 ctgctcccaa cctttcacac gtcatcaatc ctttggcctg gccttcctcc gagtacgttc
     1021 ctctctggac tctctgtctg accctgtaaa ggatccctca tcccctggga gctctgggct
     1081 taatcagaac tcttctgata agctggagtc tgatcctagc ccctggctga ctaatccttc
     1141 tatccggagg accttcttcc cagatcccca gacgagcacc aaggaaattt cagcgctcaa
     1201 gggtatgttg aagcagttgc agccagggcc tctggggcgg gcagcccgca tggtgctttc
     1261 tgctgcccat aaggcacctc cagccagtgt cgtaagccca aacaatagcc atggagaacc
     1321 agattccagt catcccgagc gtgcagagcc cagagcagaa gaaccaaaca ggaagaacaa
     1381 tgcaagcaga gggaagagga ggaaagtcca ggagcaaagg agaccgttgt ccagctcaag
     1441 ctctcagcca aataggaggg caacaggaag gacaaagcaa agacagcaac gacctcaggc
     1501 caaaagtgat ggcagtggtg tgcaggctac tggacagtgt cccatttgta caggttcctt
     1561 cagtattgag gctcttcccc ggcatgctgc cacttgtgga gagagctccc caccccagcc
     1621 agcttctcct acctccttgt cttcctcaga gtctgtgctg tgggtgtctt ccccagagag
     1681 ctcgccgcca ccatcttcct gggtccaatg ccctatttgt gaattacagt tctcggcaag
     1741 agaaatagaa gaacatgcca gcgtgtgtgg ggaagttttt ccagcctgag cagtgacatt
     1801 ctgctaaccc tttcttgatg ttggagcctg gggaatggat ctcttgtggc taagaagcat
     1861 tggtcccctc ccttctgtga ttacctcagg actctgcctg cctgaggaca ctttggaccc
     1921 agcttgctcc ccattcccgt tgccaaggct gtgtcactat ggtacccaat tctcataagg
     1981 atattttccc cttagaacat atttggtaga attgatgatc tctccaaggc cttagaacac
     2041 tatctagaat gtgatttcca atgcccattt ccctgaaagg aaaacggagg ctcacctagg
     2101 gggaaatact gcctgaaaat tataaagtcc tatgatggtc tgggaagatg agtgagtctt
     2161 gagcatgaca ctgacactga gtcccatctg accttgacct tctatatctt tcatgggtgt
     2221 ctgccccagg tgtaatcaga tactgccctg aaacttcaca ctacttacca taggtgtgga
     2281 atggacgttc agtgacacaa aaacccctca cagggttctt aaaggaacca gagagatttc
     2341 cttctaagga ataggcgtgg ctgtaaaagt ttgagcaaat ctcgttctaa ctatttgaga
     2401 tagttggacc atagtgtctc cccaaggtcc cctggagctg cgatggtcca attctgcttt
     2461 gaagaattat gcacgcttcc cttttcccca ggagatgtct tcatgtggca ctaacacccg
     2521 tcccccttat ccccaaggta cagggcaggg agagagcagc tggtcctggt gaagggaggg
     2581 cttggggtgg ggccttgagt gggaatgaaa gagcatgtga gccgcagtca agggagaggc
     2641 agagcaggag ttcaagcctt cagcccctgc ccacagaagt gggtgcagcc atggatcccc
     2701 tttcggtaag agacccttgc ttccctcccc tcctcatccc agtccccagg gggatgcagg
     2761 gacagcctgc tgctgttggt gggagagccc ctggattcct gatccagggc ctagaagaaa
     2821 agagcaggga gctggacctg gtagaacagg acgcaacagt accaaggagg ggagatgctc
     2881 tccaaggtag aaggcagagt gagagtatcc ggtggaggga aagcacctta aggtcctact
     2941 agagtctttc atagagaaag ggtttaggga aagtgcagct taaagaccct ctgtgtgggc
     3001 atgtctgaac ttgtccttca gagagatgag cagctacaag atgggaactg gattcctgtc
     3061 ggatgtgtat aggttaggtg cctagtgcgg ccccaaccac ctactttaat cacctctctt
     3121 cagggaacta acttgggccc tgttatgtct gatttttata agaatggaag tgggctgagt
     3181 aaatactccc catactagct tttcctacat gagtctacat aataaaatgg tgaacaaga
//
LOCUS       NM_001437167            2385 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus maestro (Mro), transcript variant 4, mRNA.
ACCESSION   NM_001437167
VERSION     NM_001437167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2603675.1,
                                           SRR26643287.35234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               JAXUCZ010000018.1  69725889-69726275
            388-515             JAXUCZ010000018.1  69732094-69732221
            516-615             JAXUCZ010000018.1  69732881-69732980
            616-762             JAXUCZ010000018.1  69735312-69735458
            763-945             JAXUCZ010000018.1  69736744-69736926
            946-1101            JAXUCZ010000018.1  69740845-69741000
            1102-1209           JAXUCZ010000018.1  69741592-69741699
            1210-2385           JAXUCZ010000018.1  69741987-69743162
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2385
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="maestro"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
     exon            1..387
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            388..515
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1263
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein maestro"
                     /codon_start=1
                     /product="maestro isoform 2"
                     /protein_id="NP_001424096.1"
                     /db_xref="GeneID:361348"
                     /db_xref="RGD:1559803"
                     /translation="MCSKTKMTEKTNPHPPLRPTESAALMRGCLRGLESVSFMEQMQR
                     IPNQPLPTPASQSKKRRTPLSSFFSKVSWKLRLQKREPLKNLFFVLAERARGPNPRKR
                     HLAMRGLGILAHEAPDKVRKYKKVMLDLLVHGLYDPVSSEVIHESVKTLTIMLGKIQG
                     QRLGSFFIDITLQTRTLLDDEDDSVRYSAFVLFGQLAAFAGRKWKKFFTHQVNQTQDS
                     LLSHLQDESPQVAKACTMAVQACVPYLKPRKEQSFQSEEDQKNRRLSQQLSHYHPEIL
                     LFFYANKIL"
     misc_feature    661..747
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    661..747
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    673..1116
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    673..1116
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [General function prediction only];
                     Region: HEAT; COG1413"
                     /db_xref="CDD:441023"
     misc_feature    781..888
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    781..888
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    913..990
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    913..990
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     exon            516..615
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            616..762
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            763..945
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1101
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1209
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2385
                     /gene="Mro"
                     /gene_synonym="AABR07032520.1; RGD1559803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaggggc aggaacagca agcagcaggc aggagacacc tcggcagtct ggagcgcaaa
       61 ggcgcagcat cttgggcgga ggaaggacaa ccttgtgggt gtcattggag ggcagttccc
      121 tcccccacct caccacctcg tactggcgga tcctccctct ctttgatttg tctcgctttc
      181 ctatgctctg ctggctccaa attccgagag gaccttctgg cttctctttt tgtaggtaag
      241 gaaaccaggg ctgggaaaat ctcgctgact caccacattt ggaggccaat cccgaatcgg
      301 tggaacaacg cgcctcccga gagacccagg actagcctcc agccccgaaa cagcggttct
      361 tcacgtgaca gtcaccccag gagccagggc catctgacct cgaaaatgtg ctcaaaaaca
      421 aagatgacag agaagacaaa tccccaccca cctctacgcc ccaccgaatc agctgctctg
      481 atgcgtggct gcctaagagg gctggaatct gtcagtttca tggaacaaat gcagagaatc
      541 ccgaaccagc ccctccccac ccctgcttct cagtccaaga agaggaggac accactgtca
      601 tctttctttt ccaaggtctc ttggaaactg aggttgcaga agcgggaacc tttgaagaat
      661 ctgtttttcg tcttggcaga aagagcccgg ggtcctaatc ctagaaagcg ccatctagca
      721 atgagaggcc tgggtatctt ggcccatgaa gctcctgaca aggtgagaaa gtataagaaa
      781 gttatgcttg acctgctggt acacgggctg tatgatcctg tgagttccga agtcattcat
      841 gagagtgtga agacgctgac tatcatgttg ggcaagatcc agggccaacg gctgggctcc
      901 ttcttcatag acatcaccct tcagacccgg accctattgg atgatgagga tgacagcgtg
      961 cgctactcag cctttgtcct ctttgggcag ttggctgcat ttgctgggcg gaaatggaag
     1021 aagttcttca cccaccaggt caaccagacc caagattccc tcctaagcca tttgcaggac
     1081 gaaagccctc aggttgccaa ggcttgcaca atggctgttc aagcctgtgt tccatacctg
     1141 aaacccagaa aggagcagag tttccaaagt gaagaagacc agaagaaccg caggctttcc
     1201 cagcaactga gccactacca tccagagatc ctgctgttct tctatgccaa taaaatcctg
     1261 taggtccaga gcagcagaga aagcccacgg gagtgccctg ccccggcatg gaatttccca
     1321 tctgtctcat aggatacctc tttgactctc gagtgattgt aagagaaaag aggatgtcag
     1381 agagcaactg aaaaaaaaat caccctggag tgcacgcaaa gtaaaattct atgcaagtgt
     1441 gtgcacatac atgcacatga ctgtggaggt cagaggacga cctcactgct gttcctaagg
     1501 cgtcatccat ctttccactg aaacaggatc tttgactggc ctggggcttg caggagctta
     1561 gactaggctt gatagctagt gagccagctc tggggttata accacagtcc atcgaaccaa
     1621 ccgtttttga ctgtgccaaa ttcaggccct tatacctact tgtgctgact aagccgtctc
     1681 cccagcccag tagatgcaca cttccttaaa acatttaaca tgcatgatgt cccaatccct
     1741 cctttctcac tccctctctg ccaggtgaca cacatttata atatgtaact tctgaggctt
     1801 gggggaacaa ttgttacctt aaacattttt aaactgtatt tgtttttgat agtttgctat
     1861 ttgctacgga ccaggagacc aaggagctgg cttacaatgt gtctttaatt tcggatgatc
     1921 ttaaaatgtc atggtcttaa aatcgtcttt aaaaagaaca acaaggaaaa gaaatattgt
     1981 tgaaaatcca ctgaatgatg ataagttaca gaataaaaac agtaacattt actgagaatg
     2041 cttacaactt atttcggtac tgtggtggtt tggatgagcg accctgcagg cttacgtatt
     2101 tgaatgcttg gtcccttctt agtggaagtg tttaggaggg gttagagggt gtgtatatca
     2161 ctggagatgg aatttgagac ttcagaagcc caagcaaggc cctgtctgtc tgtctgtctg
     2221 tctgtctgtc cgtctcttat tttgcctgcc tactgtctac agatcaagac gtaaagctct
     2281 cagttactac tctagcacca tgcctgtcta ctcctaccat gatgataatg aactggcctt
     2341 ctaaaactct aagccagccc caattaaacg cttcctttta taaga
//
LOCUS       NM_001437441            2660 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus potassium voltage-gated channel modifier
            subfamily G member 2 (Kcng2), transcript variant 2, mRNA.
ACCESSION   NM_001437441 XM_006254947
VERSION     NM_001437441.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Zhu,X.R., Netzer,R., Bohlke,K., Liu,Q. and Pongs,O.
  TITLE     Structural and functional characterization of Kv6.2 a new
            gamma-subunit of voltage-gated potassium channel
  JOURNAL   Recept Channels 6 (5), 337-350 (1999)
   PUBMED   10551266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254947.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.54839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000018.1  76083952-76084047   c
            97-794              JAXUCZ010000018.1  76044975-76045672   c
            795-2660            JAXUCZ010000018.1  76017197-76019062   c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2660
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 2"
                     /db_xref="GeneID:307234"
                     /db_xref="RGD:1309521"
     exon            1..96
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..794
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    108..110
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="upstream in-frame stop codon"
     CDS             132..1574
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="cardiac potassium channel subunit (Kv6.2);
                     voltage-gated potassium channel subunit Kv6.2; potassium
                     voltage-gated channel, subfamily G, member 2; potassium
                     channel, voltage gated modifier subfamily G, member 2"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG2"
                     /protein_id="NP_001424370.1"
                     /db_xref="GeneID:307234"
                     /db_xref="RGD:1309521"
                     /translation="MARLPGHPEVPGAEPGSAVRGGRGGRGARARHVIINVGGCRVRL
                     AWAALARCPLARLERLRACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAG
                     KLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARATPPARGPQTSP
                     GRALGSGRLERGRRRLRDVVENPHSGLAGKLFAYVSVAFVAVTAVGLCLSTMPDVRAE
                     EERGECSTKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAIIDILAILPFY
                     VSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCARE
                     FGLLLLFLCVAMALFAPLVHLAERELGAHRDFSSVPASYWWAVISMTTVGYGDMVPRS
                     LPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPVLREDSTRDD
                     STRSASATEDSSQDPETAGAAGSLPGPVGP"
     misc_feature    132..206
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    228..512
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in KCNG/Kv6
                     subfamily of potassium voltage-gated channels; Region:
                     BTB_POZ_Kv6_KCNG; cd18382"
                     /db_xref="CDD:349691"
     misc_feature    228..512
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in KCNG/Kv6
                     subfamily of potassium voltage-gated channels; Region:
                     BTB_POZ_Kv6_KCNG; cd18382"
                     /db_xref="CDD:349691"
     misc_feature    order(237..239,243..266,273..275,381..383,387..392,
                     399..401,408..410,420..422,429..431,438..440,444..446,
                     468..473,480..482)
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="putative tetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:349691"
     misc_feature    order(237..239,243..266,273..275,381..383,387..392,
                     399..401,408..410,420..422,429..431,438..440,444..446,
                     468..473,480..482)
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="putative tetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:349691"
     misc_feature    561..632
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    693..758
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    699..1418
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    699..1418
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    822..887
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    921..983
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1020..1082
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1128..1193
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1275..1292
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
     misc_feature    1320..1406
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     transmembrane region"
     misc_feature    1416..1571
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYU3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            795..2660
                     /gene="Kcng2"
                     /gene_synonym="Kv6.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactctgag cagtgggctc tggggacgct gcgctccacc cggaggagag ccacggcagg
       61 gcacgcggag caagcagccg ggagcccggg caggaggccc tgtctcctga tcgcggccgg
      121 catatggggc catggcccgg ctcccggggc acccggaggt ccccggcgcc gagcctggca
      181 gcgcagtccg agggggccga ggcggccgcg gggcccgggc gcgccacgtc ataatcaacg
      241 tcgggggctg cagggtgcgt ctggcctggg ctgcgctggc ccgctgtccc ctggctcgcc
      301 tcgagcgcct gcgagcctgc cgcggccacg acgagctgct gcgcgtgtgt gacgactacg
      361 acgtgagccg cgacgagttc ttcttcgacc gcagcccgtg cgctttccgc gccatcgtgg
      421 cgctgctgcg cgccggcaag ctgaggctgc tgcgcggccc gtgcgccctg gccttccggg
      481 acgagctggc ctactggggc atcgacgagg cgcggctgga gcgctgctgc ctgcgccgtc
      541 tgcgccgtcg cgaggaggag gccgccgagg cgagggccac gccgcccgcc cgagggccgc
      601 agaccagccc cggccgagcc ctggggagcg ggcggctgga gcgaggccga cggcgcctgc
      661 gcgacgtggt ggagaacccg cactccgggc tggcgggcaa gctcttcgcc tacgtctccg
      721 tggccttcgt ggccgtcacg gccgtgggcc tgtgcctgag caccatgcct gacgtccgcg
      781 cagaggagga aaggggcgag tgctccacca agtgccgcaa cctcttcgtg ttggagacag
      841 tgtgcgtggc ctggttctcc ttcgagttcc tgctgcgctc cctgcaagcc gagagcaagt
      901 gcgccttcct ccgtacgcct cttgccatca tcgacatcct ggccatcctg cccttctacg
      961 tgtcgctgct cgcgggactg gccgcagggc ccacgggcag caagatgctg gaacgcgcgg
     1021 ggctggtact gcggctactg cgggcgctgc gcgtgctcta cgtgatgcgc ctggcgcgcc
     1081 actcgctggg gctacgctcg cttggcctca ccgtgcgccg ctgcgcgcgc gagttcggac
     1141 tgctgctgct cttcctctgc gtggccatgg cgctcttcgc gccgctcgtg cacctggctg
     1201 agcgcgagct gggcgctcac cgcgacttct ccagcgtccc cgccagctac tggtgggcag
     1261 tcatctccat gaccaccgtg ggctatggag acatggtgcc acgcagcctt ccgggccagg
     1321 tggtggcgct gagcagcatc ctcagcggca tcctgctcat ggccttccct gtcacctcca
     1381 tcttccacac cttctcgcgc tcctactcgg agctcaagga gcagcagcaa cgcgcggcca
     1441 gccctgaacc ggtcctgcgg gaggacagca cacgcgacga cagcacgcgt tcggccagcg
     1501 ccaccgagga cagctcccag gacccggaga ccgcaggtgc cgcagggagc ttgccaggcc
     1561 cggtgggacc ctgagctgta ctgagaactt cagagtcaaa gcctcagagg acaccaagcg
     1621 ctggctgacc caggagtcgc aaacttggcc tggcatgtcg tcgttgcagc tgccttggct
     1681 cccccaagca accccgagct tcgcgtagcc tggaggagat cgcaacctgg tctttctttt
     1741 tccttttatt tttccctcca gttttaaatt ttctatggtt aattaaaaat tgagtcccag
     1801 aaattccaag tcttaagcaa atgtcagcta ccctggacta aagttttgcc cttctgtgct
     1861 cttaatctag ggcagcccca gggaacagaa gatggcattt acctggtgac ccttagtggc
     1921 caatacccca tcaaaaagag ggcatcagct gacatctgtc actgccagtg tccacatcac
     1981 ctgccaagtg ttgggtagtt gacaggacac ttagccccct agttctgcct atccaccctt
     2041 tgcagggggg ggaagaaatc tcagagttga cctctgttcc cccaaaccat ctcaatcaga
     2101 agataagacc cctgctcgct tgcatagtgg ccttttaacc cttcccctgc cctcctccct
     2161 ggtctgcagg aatgttgcct gtcttcgggg ggatactggt gtctcttctg gtgggacatt
     2221 tccctcagat gcggctcaag tgaaaacctt gaacaagggt agtgggctaa ggaggcagtt
     2281 cagggagaag tcagcgaggg cacagccagg agggggcatg gccttcctct actccatgga
     2341 ggctgttgct ttgccctgtt tcaacaagcc tcgggcggtg gcctaagccc aagattctgg
     2401 cacttgggaa gtaggcacag gaagatcgga agttcggtga gcacccaaca tagtcacaga
     2461 cgctctgtcg gaagtaaggt cttcggtctg cagtccatca tcactgcctg ccacacagta
     2521 gctttcagca aggcccctat gggagctcag gacaggccca tttggggctc ttacaccaca
     2581 ggctttgcaa gaaatctact gcaaccaaat aaaaaaaaat tgccagcccc tcctcatggc
     2641 agtaggctga gttcctctca
//
LOCUS       NM_001437371            2817 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 1 (Mbd1),
            transcript variant 1, mRNA.
ACCESSION   NM_001437371 XM_006254909
VERSION     NM_001437371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Dick,A.L.W., Zhao,Q., Crossin,R., Baker-Andresen,D., Li,X.,
            Edson,J., Roeh,S., Marshall,V., Bredy,T.W., Lawrence,A.J. and
            Duncan,J.R.
  TITLE     Adolescent chronic intermittent toluene inhalation dynamically
            regulates the transcriptome and neuronal methylome within the rat
            medial prefrontal cortex
  JOURNAL   Addict Biol 26 (3), e12937 (2021)
   PUBMED   32638524
  REMARK    GeneRIF: Adolescent chronic intermittent toluene inhalation
            dynamically regulates the transcriptome and neuronal methylome
            within the rat medial prefrontal cortex.
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Tang,W.Y., Morey,L.M., Cheung,Y.Y., Birch,L., Prins,G.S. and
            Ho,S.M.
  TITLE     Neonatal exposure to estradiol/bisphenol A alters promoter
            methylation and expression of Nsbp1 and Hpcal1 genes and
            transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate
            gland throughout life
  JOURNAL   Endocrinology 153 (1), 42-55 (2012)
   PUBMED   22109888
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Ohki,I., Shimotake,N., Fujita,N., Jee,J., Ikegami,T., Nakao,M. and
            Shirakawa,M.
  TITLE     Solution structure of the methyl-CpG binding domain of human MBD1
            in complex with methylated DNA
  JOURNAL   Cell 105 (4), 487-497 (2001)
   PUBMED   11371345
  REMARK    Erratum:[Cell 2001 Jun 15;105(6):815]
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254909.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.51931.1,
                                           SRR26643285.52684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000018.1  70145239-70145384
            147-271             JAXUCZ010000018.1  70146463-70146587
            272-386             JAXUCZ010000018.1  70150233-70150347
            387-607             JAXUCZ010000018.1  70150437-70150657
            608-690             JAXUCZ010000018.1  70150736-70150818
            691-731             JAXUCZ010000018.1  70151001-70151041
            732-878             JAXUCZ010000018.1  70151376-70151522
            879-1007            JAXUCZ010000018.1  70151617-70151745
            1008-1118           JAXUCZ010000018.1  70152116-70152226
            1119-1187           JAXUCZ010000018.1  70152308-70152376
            1188-1355           JAXUCZ010000018.1  70152876-70153043
            1356-1655           JAXUCZ010000018.1  70153375-70153674
            1656-1793           JAXUCZ010000018.1  70153761-70153898
            1794-1925           JAXUCZ010000018.1  70154230-70154361
            1926-1987           JAXUCZ010000018.1  70154449-70154510
            1988-2817           JAXUCZ010000018.1  70158915-70159744
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..2817
                     /gene="Mbd1"
                     /note="methyl-CpG binding domain protein 1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
     exon            1..146
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Mbd1"
                     /note="upstream in-frame stop codon"
     exon            147..271
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2060
                     /gene="Mbd1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 1 isoform 1"
                     /protein_id="NP_001424300.1"
                     /db_xref="GeneID:291439"
                     /db_xref="RGD:1305980"
                     /translation="MAEAWQDCPALGPGWKRREAFRKSGASCGRSDIYYRSPTGEKIR
                     SKIELTRYLGPACDLTLFDFRQGILCHPVPKTHPLAVPSKKKKKTSKPAKAKKQQVGP
                     QRSEVRKETPREGNKVAPATALLPVTASAPAPVPVPVSAPAPAPAPLCCENCGIHLSW
                     DGIKRERRRTLCKDCRAQRIAFNREQRMFKRVGCGECTACLVKEDCGVCSICCLQLPN
                     DVASGLFCKCEQRRCLRIVEKNRGCGVCRGCQTQEDCGHCRICLRFPRPGLKRQWRCL
                     QRRCFWGKYDHSKRGPRVASRRHSRAPPLPPHAASQHPEPTELHISDQTPTAPAEFVY
                     DCVEEDELQPYTNQRQNRKCGACAACLRRMDCGHCDFCCDKPKFGGSNQKRQKCRWRQ
                     CLQFAMKRLLPSIGPGSEEEARLLPHHTHQKRSASTRQLQLSSPLKAPLAVVTTPPGP
                     VQDSGKRQAGSGFVLPQPDTDLVYLQEGTSSLMQVPGPAAASTENPAQETQGSAPGWV
                     VALPQVKQEKADAPEEWTAVTTFLTSSTVQPGFLSKASGLDPPPVKREPPGPEEDGEE
                     NKEDDVSESAPAEEIGGIGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNENEYFTE
                     LQLKEEIL"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    174..359
                     /gene="Mbd1"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; Region:
                     MeCP2_MBD; cd01396"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    order(213..215,219..221,225..227,249..251,255..257,
                     282..284,291..293,303..305)
                     /gene="Mbd1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    717..860
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    864..1001
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1200..1340
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     misc_feature    1200..1340
                     /gene="Mbd1"
                     /note="CXXC zinc finger domain; Region: zf-CXXC;
                     pfam02008"
                     /db_xref="CDD:366873"
     exon            272..386
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..731
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..878
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1007
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1118
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1187
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1355
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1655
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1793
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1925
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1987
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2817
                     /gene="Mbd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcga caactactgt tttggaagag gctgcggtgg aagaggagga agaagaagag
       61 tagaaccggc gggtcgcgca agcgggatcc ttcccatggg tccaccggcc tagagccgag
      121 gaagctgcga gcctggtgtc aagctggctt ctgaagcatc tatggctgag gcctggcagg
      181 actgcccagc cctgggccct ggctggaaac gccgagaggc ctttcgaaag tcaggggcct
      241 cgtgtggacg ctcagacatc tattatcgga gccccacagg agaaaagatc cgaagcaaaa
      301 ttgagctgac tcgatacctg ggccctgcat gcgatcttac cctgtttgac ttcagacaag
      361 gcatcttatg ccacccagtt cccaagaccc atcccttggc tgtccccagc aagaagaaaa
      421 agaagacttc taaaccagcc aaggctaaga aacagcaggt tgggccacag agaagtgagg
      481 tcaggaaaga gactccacgg gaaggaaata aggtcgctcc tgccacagct ttattacctg
      541 tgactgcgtc tgcgcctgca cctgtgcctg tgcctgtgtc tgcacctgcg cctgcacctg
      601 cacctttgtg ctgtgagaat tgtggaatcc acctgtcatg ggatggtatc aaaagggaga
      661 gacgcaggac attgtgcaaa gactgccgag cacagagaat tgccttcaac cgagaacagc
      721 gaatgtttaa gcgagttggc tgtggggagt gcacagcttg cctggtgaaa gaagactgcg
      781 gggtgtgctc catctgctgc ctgcagctgc ccaacgatgt ggcctcaggg ctcttctgca
      841 agtgtgagca gagacgctgc ctgcggattg tggagaagaa ccgagggtgt ggtgtgtgtc
      901 ggggttgtca gacccaagag gactgtggcc attgccgcat ctgccttcgc tttccccgcc
      961 ctggtctcaa gcgccagtgg aggtgtttgc aacggcgctg tttttggggt aaatatgatc
     1021 atagtaagag aggcccgagg gtagcttctc gacgtcactc ccgagccccg ccacttcctc
     1081 cacacgctgc gtcacagcat ccagagccca cagaactgca catcagcgac caaacgccca
     1141 cagcacctgc tgagttcgtc tatgactgtg tagaggagga cgagctacag ccctatacga
     1201 accagcggca gaaccgcaag tgtggggcct gtgcagcctg cctacggcgg atggactgtg
     1261 gccactgcga cttctgctgt gacaagccca aattcggggg cagcaaccag aagcgccaga
     1321 agtgtcgttg gcgccagtgc ctgcagtttg ccatgaagcg gctgctgccc agtattgggc
     1381 cagggtctga ggaggaagca agattgcttc cacatcatac ccaccaaaag aggtctgctt
     1441 ctactcgaca gctgcaactg agctctccct taaaggctcc tttggctgtg gtcacaaccc
     1501 caccgggccc tgtccaagat tcagggaagc ggcaagcagg tagtggcttt gtactgcccc
     1561 aacctgacac agaccttgtg tatttacaag agggtaccag cagtctcatg caggtgcctg
     1621 gccctgctgc agcttccaca gaaaacccag cacaggagac ccagggctct gccccaggtt
     1681 gggttgtggc cttgccccag gtgaagcaag agaaggcgga tgccccagag gagtggacag
     1741 cagtcacaac cttcctgact tcttccacgg tgcagcctgg cttccttagc aaggcgtcag
     1801 gcctggaccc tccacctgtg aaacgagagc cccctggccc tgaggaggat ggagaagaga
     1861 acaaagaaga tgatgtctct gaatcagctc cagcagaaga gataggaggg attggcaccc
     1921 cagtgatcac ggagattttc agcctgggtg gaacccgcct ccgggatgca gaagcctggt
     1981 tgccaaggct acataaactg ttagcagtaa atgaaaatga gtattttact gagctgcagt
     2041 tgaaagaaga aatattgtag gagagaaaag caattattat taagagaaga aagacattct
     2101 tttgtggctg aaaagctgaa cctggaattc aggaaatgga atctaaatct agagatgtac
     2161 catgtagaaa atctgaagtg ggtgggttac aaataattaa gcacactaat ttgaagaaaa
     2221 ccatccttaa acatgtgtac acatggattg cacttagtat ctgtcagtga ctggccttat
     2281 tactgtcctc ccccttcctc ttcttgttcc cccatccctc ttaacagggg caccacagta
     2341 gcagtcagtt tgctcttaag cagtgtaact ccgttttatg gttactagga gctacaactc
     2401 tggtttccat gtatgctgaa gaccgtctag tttcctggac tgcattgcca gttttgcctg
     2461 ggatcccgat tctcaagaat tgagtatctg aacttctgat ccgaagctca ttcctccagt
     2521 cagacaactg ccctgctagt atttctgatc tgccctcttc ctgtgttagc ccaaagtgtg
     2581 ggccccattt tctgttcagt gcagtaggaa gattttgttc acagatctta ctggttgtgt
     2641 agctcgacaa ggcactttgg cttcctgagc cttagttgac ttcactgcaa actaaagcca
     2701 ataccctcag ttccttcaac cctgtaagaa ttttgtcaac ctcaaaggtt gtttctggaa
     2761 atactttgca aattgtaaaa aaaaaaaaaa aaaaaaaaaa aagagagaga aacaata
//
LOCUS       NM_001437273            4948 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), transcript variant 1, mRNA.
ACCESSION   NM_001437273 XM_039110503
VERSION     NM_001437273.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4948)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 4948)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 4948)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4948)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4948)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 4948)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 4948)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 4948)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 4948)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 4948)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039110503.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.21987.1,
                                           SRR26643284.8348.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  165425848-165425899 c
            53-171              JAXUCZ010000005.1  165403843-165403961 c
            172-344             JAXUCZ010000005.1  165392825-165392997 c
            345-573             JAXUCZ010000005.1  165389591-165389819 c
            574-803             JAXUCZ010000005.1  165389275-165389504 c
            804-983             JAXUCZ010000005.1  165388373-165388552 c
            984-1133            JAXUCZ010000005.1  165388101-165388250 c
            1134-1223           JAXUCZ010000005.1  165387693-165387782 c
            1224-1445           JAXUCZ010000005.1  165386476-165386697 c
            1446-1542           JAXUCZ010000005.1  165385787-165385883 c
            1543-1673           JAXUCZ010000005.1  165385559-165385689 c
            1674-1724           JAXUCZ010000005.1  165384765-165384815 c
            1725-1892           JAXUCZ010000005.1  165384521-165384688 c
            1893-2014           JAXUCZ010000005.1  165384309-165384430 c
            2015-2158           JAXUCZ010000005.1  165383996-165384139 c
            2159-2258           JAXUCZ010000005.1  165383697-165383796 c
            2259-2437           JAXUCZ010000005.1  165383289-165383467 c
            2438-2550           JAXUCZ010000005.1  165383088-165383200 c
            2551-2629           JAXUCZ010000005.1  165382877-165382955 c
            2630-2797           JAXUCZ010000005.1  165382365-165382532 c
            2798-2921           JAXUCZ010000005.1  165381666-165381789 c
            2922-3067           JAXUCZ010000005.1  165381296-165381441 c
            3068-3200           JAXUCZ010000005.1  165380825-165380957 c
            3201-4948           JAXUCZ010000005.1  165378057-165379804 c
FEATURES             Location/Qualifiers
     source          1..4948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4948
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..52
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            53..171
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            172..344
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="Pik3cd"
                     /note="upstream in-frame stop codon"
     CDS             204..3338
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="isoform a is encoded by transcript variant 1;
                     catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform a"
                     /protein_id="NP_001424202.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQ
                     LQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
                     LLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
                     LDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVL
                     MKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTL
                     LEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMD
                     FLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALL
                     NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
                     FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
                     LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
                     VNWLAHNVSKDNRQ"
     misc_feature    303..524
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    303..524
                     /gene="Pik3cd"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:460483"
     misc_feature    747..1046
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    747..1046
                     /gene="Pik3cd"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:395642"
     misc_feature    1143..1646
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1143..1646
                     /gene="Pik3cd"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1713..2255
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    1713..2255
                     /gene="Pik3cd"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); Region: PI3Ka; smart00145"
                     /db_xref="CDD:214537"
     misc_feature    2229..3329
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    2229..3329
                     /gene="Pik3cd"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; Region: PI3Kc_IA_delta; cd05174"
                     /db_xref="CDD:270718"
     misc_feature    order(2457..2459,2463..2471,2475..2477,2481..2483,
                     2532..2534,2538..2540,2547..2549,2640..2642,2676..2687,
                     2700..2702,2709..2711,2895..2897,2901..2903,2931..2936)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2457..2459,2463..2471,2475..2477,2481..2483,
                     2532..2534,2538..2540,2547..2549,2640..2642,2676..2687,
                     2700..2702,2709..2711,2895..2897,2901..2903,2931..2936)
                     /gene="Pik3cd"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2661..2666,2967..2972,2976..2978,2982..2984,
                     3180..3182,3189..3191)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    order(2661..2666,2967..2972,2976..2978,2982..2984,
                     3180..3182,3189..3191)
                     /gene="Pik3cd"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2802..2804
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2802..2804
                     /gene="Pik3cd"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270718"
     misc_feature    2871..2897
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2871..2897
                     /gene="Pik3cd"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     misc_feature    2934..3008
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     misc_feature    2934..3008
                     /gene="Pik3cd"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270718"
     exon            345..573
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            574..803
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            804..983
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1133
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1223
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1445
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1542
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1673
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1724
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1892
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2014
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2158
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2258
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2437
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2550
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2629
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2797
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2921
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3067
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3200
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..4948
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctcct tgcctcgggg ctgccagctc cgcgggcgca gccgctggac cgacacataa
       61 ggagctgaga gccaggcaga agtgggatga agctccctga tggcaaagca cctgtaatct
      121 cccaggcaca ggggccttgg ctggtggtcc ttctcggccc atcccaaaca ggagaacagg
      181 cctcagagaa gtaacacagc aggatgcccc ctggggtaga ctgccccatg gagttctgga
      241 ccaaagagga gagccagagc gtggccgttg acttcttgct gcccacagga gtctacttga
      301 acttccctgt gtcccgcaat gccaacctca gcaccatcaa gcaggtgctg tggcatcgtg
      361 cacagtatga gccgttcttc cacatgctca gtgaccccga ggcttatgtg ttcacctgtg
      421 tgaaccagac agcggagcag caggagttgg aggatgagca gcggaggctg tgtgacatcc
      481 agcccttcct gcccgtgctg cgcctggtgg cccgagaggg ggaccgcgtg aagaagctca
      541 tcaactcaca gatcagcctc ctcatcggca aaggtctcca tgagtttgat tccctgcggg
      601 acccggaagt aaacgacttc cgcactaaga tgcgccagtt ttgcgaagag gccgcggctc
      661 accgccagca gctgggctgg gtggaatggc tgcagtatag cttccccctg cagctggagc
      721 cctcagccag aggttggcgg gctggcttat tgcatgtcag caaccgaccc ctgctggtca
      781 atgtgaagtt cgagggcagt gaggagagct tcaccttcca ggtatccacc aaggacatgc
      841 ccctcgcact gatggcctgt gccctccgaa aaaaggccac cgtgttccgg cagcctctgg
      901 tggagaggcc tgaggagtat gccctgcagg tgaacgggag gcacgagtac ctctacggca
      961 gctaccccct ctgccacttt cagtacatct gtagctgcct gcacagcgga ctgactcccc
     1021 atctgaccat ggtccactcc tcctccatcc tcgccatgag ggatgagcag agcaaccctg
     1081 ccccccaggt gcagaagcca cgagtcaaac ctcccccgat ccctgccaag aagccctcct
     1141 ctgtgtccct gtggtccctg gaacagccat tctgcattga gctgattgag ggccgcaagg
     1201 tgaatgcgga tgaaaggatg aagctggttg tgcaggccgg gctcttccac ggcaatgaga
     1261 tgctgtgcaa gactgtgtcg agctcagagg tgaatgtgtg ctcagagccc gtgtggaagc
     1321 agcgactaga attcgacatc agcatctgtg acctcccccg aatggcccgg ctctgctttg
     1381 cactctatgc tgtcgtggag aaggctaaga aggcgcgctc cacaaagaag aagtccaaga
     1441 aggcggactg tcccatcgct tgggccaacc tcatgctatt cgactacaaa gatcagctca
     1501 agacgggcga acggtgcctc tacatgtggc cctctgtccc agatgagaaa ggggaactga
     1561 tgaatcctgc gggtacagta cgtggtaacc ccaacacaga gagtgccgct gccctggtca
     1621 tctacctacc tgaggtggct ccccaccctg tgtacttccc tgctctggag aagatcctgg
     1681 agctggggcg tcacggggag cgtgggcgca tcacagagga ggagcagctg cagctgcggg
     1741 agatcctgga gcggcgggga tctggggaac tgtacgaaca tgagaaggac ctggtgtgga
     1801 agatgcgtca cgaagtccag gagcatttcc cagaggcgct ggcccgcctg ctactggtca
     1861 ccaagtggaa taaacatgag gatgtggccc agatgctcta tttgctgtgc tcctggcccg
     1921 agcttcctgt gctgagcgcc ctggagcttc tggactttag ttttcctgac tgctacgtgg
     1981 gttccttcgc catcaagtcc ctacggaagc tgacggatga cgagcttttc cagtaccttc
     2041 tgcagctggt acaagtactc aaatatgagt cctacctgga ctgcgagttg accaaattct
     2101 tgttgggccg agccctggct aaccgcaaga tcgggcactt cctgttctgg cacctccgct
     2161 ctgagatgca tgtaccgtcc gtggccctgc gttttggcct catcatggaa gcctactgca
     2221 gaggcagcac ccaccacatg aaggtgctga tgaagcaggg ggaggcactg agcaagctta
     2281 aggccctgaa tgactttgtg aaggcgagct cgcagaagac caccaagccc cagaccaagg
     2341 agatgatgca tatgtgtatg cgccaggaga cttacatgga ggcgctgtcc cacctgcagt
     2401 ctcccctcga ccccagcacc ctgctggagg aagtctgtgt ggagcagtgc accttcatgg
     2461 actccaaaat gaagccattg tggatcatgt acagcagcga gaaggcaggc ggtgccggca
     2521 gcgtgggcat catctttaag aacggggatg acctccgcca ggacatgctg actctgcaga
     2581 tgatccagct catggacttc ctatggaagc aggagggcct ggacctgagg atgaccccct
     2641 atggctgcct ccccaccgga gatcgcacag gcctcattga ggtggtcctc cactcggaca
     2701 ccatcgccaa catccagctg aataaaagca acatggcagc cacggctgcg ttcaacaagg
     2761 acgctctgct caactggctc aagtctaaga accctgggga ggctctggat cgggccattg
     2821 aggaattcac cctctcctgt gctggctact gtgtggccac atatgtgctg ggcatcggtg
     2881 accggcacag cgataacatc atgatcagag agagtgggca gcttttccac attgactttg
     2941 gccactttct ggggaacttc aagaccaagt tcgggatcaa ccgggagcgt gtccccttca
     3001 ttctcaccta cgactttgtc cacgtgatcc agcaggggaa gactaacaac agtgagaaat
     3061 ttgaaaggtt ccgaggctac tgtgaacgag cctacaccat cctgcggcgt cacgggctgc
     3121 ttttccttca tctcttcgcc ctcatgcgcg cagcaggtct gcctgagctt agctgctcca
     3181 aagacatcca gtatctcaag gactctctgg cactagggaa gacggaggaa gaagcactaa
     3241 agcacttccg ggtgaagttc aatgaagctc tccgggagag ctggaaaacc aaagtcaact
     3301 ggctggcaca caatgtgtcc aaggataaca ggcagtaaga ggcgcccccc tgggcgtcac
     3361 attcccctgg gcgtcacatg gcagttccct ggttccctcc gggctctcag ccatagaggt
     3421 aaactgtcag tcctggagac caggcatgct cagtggtcat caaaggggcc ccagacctga
     3481 actgtccctc acagagaaga accacacaac tgcttcttgt ttacactggt tatttattta
     3541 tgactcgaaa tgtttaagga acagaatagc cataaatgga agtgcatttt tgtgcagggg
     3601 aggggtgctg tcctcgtgac cccccctccc tcagcactgt aaacagcacc ttgaggatcg
     3661 tacccctagt cttccaacct gtgggtcttg gccccccaaa ggcagttttg ggggccacct
     3721 tcccaggctc ccagccggct gcctagaaca agcctggcag tcacctggtg cctcccacgc
     3781 agacaggaca cctcaatcct cagctcagct cacctccgcc accttcatgt ggcccaccct
     3841 cggcgacctc catctaccaa gcctccggca gctcctgagg aagccaggag cttccctcta
     3901 gactcaggca cacttgctct gcactgctga agtgacaacc tcttgggtac ggaaacaccc
     3961 tcacctttta tttgcgggta agaacatgat tatgtaaact ctgtatagaa tagccggggt
     4021 aaaggacctg gcttccacta cagatagctg tgttctgggc ctcaaaacac tagagattgg
     4081 tgcccgattt agtgcggtgt ggtcgtgaat ccagacaaag ggcaagcctg aacggagtcc
     4141 tcttcgcaat ttgtgtgaga accgcacaca aaggcagctt tctggaagga caggactgat
     4201 gtctcccaga gctgccattc tcagaaggca gctggggtcc cgggttctga agtgtgcgcg
     4261 aggaggagga ccaagtttag tagtctgggc gactggagca tctccagaaa tgcagggtct
     4321 ccaccccctc ccaggtatcc aaacctactt tgggctgtag agccagtcac ctggcttttt
     4381 agagagccca gctcagtggt gcacatgcat aaaacgtgcc atcccgagcc caccgtgatg
     4441 catcagctgc cgcctcagga cctggctctc ccggtaacat cctgagactt gcagaaccat
     4501 caccgccgtc ttgctggcag cccagaacat ggctgctcaa ggaagccagg tgtccgctct
     4561 ttcacgatga tgaactgagg gtccagcagt ggttggtgcc tccagggcac ttgctgaacc
     4621 cttagtctgc cccaactctg aaataggaag tgtgcgtgcg tgtgcgtgcg tgtgcgcgtg
     4681 tgtgccgtgt tatttattga aaagagtcta ggtgctccct ggtgtggctg cagattctgc
     4741 agaggctcag cctttctggg ttgggtatgt ggtctgtgta cctggctgga aaagtatttt
     4801 ctattttttt tttttaaaag ttgttctacg tttctgtagg ggggaaggta gatttcctct
     4861 cactgatgtg ggctgagatc agtctgtgca accctgacac gtccggtaaa gacaggtgaa
     4921 aagaaataaa aatcttttta tgttctta
//
LOCUS       NM_001437111            6872 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus AT hook, DNA binding motif, containing 1 (Ahdc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001437111 XM_008764152
VERSION     NM_001437111.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6872)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 27, 2025 this sequence version replaced XM_008764152.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.20394.1,
                                           SRR26643296.16293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  150512215-150512249
            36-167              JAXUCZ010000005.1  150512501-150512632
            168-262             JAXUCZ010000005.1  150512867-150512961
            263-444             JAXUCZ010000005.1  150555407-150555588
            445-556             JAXUCZ010000005.1  150561836-150561947
            557-594             JAXUCZ010000005.1  150562081-150562118
            595-5490            JAXUCZ010000005.1  150562477-150567372
            5491-6872           JAXUCZ010000005.1  150577423-150578804
FEATURES             Location/Qualifiers
     source          1..6872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6872
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="AT hook, DNA binding motif, containing 1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
     exon            1..35
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            36..167
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            168..262
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            263..444
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            445..556
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    504..506
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="upstream in-frame stop codon"
     exon            557..594
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     exon            595..5490
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..5447
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="A.T hook DNA-binding motif-containing protein 1;
                     AT-hook DNA-binding motif-containing protein 1"
                     /codon_start=1
                     /product="transcription factor Gibbin"
                     /protein_id="NP_001424040.1"
                     /db_xref="GeneID:362617"
                     /db_xref="RGD:1310031"
                     /translation="MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPP
                     ASPPDKAFSTHTFSENPRPPPRRDPSSRRPPVLAKGDDLLPPRAARPVSQAHCPTPAP
                     DNNSLRHWDNGRVNLHPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPPG
                     DLQYSFFSSPSLANSIRSPEERATPHAKPERPNHPLYEPEPEPRDSPQPGQGHGPGAT
                     ATATGLPPEPEPDGPDYPELADADILSELASLTCPEAQLLEAQALEPPSPQPEPQLLD
                     PQPRFLDPQALEPLGEGLELPPLQPLADPLGLPSLTLQALDTLPDSLESQLLDPQALD
                     PLPKLLDVPGRRLEPQQSLGHCQLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKIL
                     CRRRKAGRGRKVDSGPEGRLLPLPMPTGLAAALAEPPPLPPPPPPPALSGPVPELEPE
                     SSQTPMVPTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKELGLR
                     VSSEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPTVVAAE
                     AAAVTAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNRQSQC
                     AGRCSPPRCWTPSEPESVHQAPDTQSISQFLHRVQGFRRRGGKTGGFGGRGGGHAAKA
                     ARCSFSDFFEGIGKKKKVVAVAATGVVGPGLTELGHPRKRGRGEVDAVTGKPKRKRRS
                     RKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEARAFA
                     STGLESGASGRGSYYAGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFALSASR
                     PESRKASGNYAGPPSSALPAQRGLATFPSRGAKGSPVAVGNSGAGTDPSFQPVLPSRQ
                     TFPPGRATSYGITPATSDCRAAETFPKLAPPPSAVARSPTTHPPANTYPPQYGGYGAG
                     QSVFAPAKPFSGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCLPPSKA
                     SFFNSSEGGPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASAASAASSSSSSFQPSP
                     ENCRQFVGASQWPFRQGYGGLDWASEAFSQLYNPNFDCHVSEPNVILDISNYTPQKVK
                     QQTAVSETFSESSSDSTQFNQPVGGGFRRANSEASSSEGQSSLSSLEKLMMDWNEASS
                     APGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFSTSTSATASGYPSKRSTGPRQP
                     RGGRGSGACSAKKERGGTAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGDSSMSPLPSQ
                     SRAFGVGERDPCDFMGPYSMNPSTPSDGTFGQGFHCDSPSLGAPDLDSKHFPPLAHPP
                     TVFDAGLQKAYSPTCSPTLGFKEELRPPPSKLTACEPLKHGLQGASLSHAAQAHLSCR
                     DLPLGQPHYESPSCKGTAYWYPPGSAARSPPYEGKVGSGLLADFLGRTEAVCLSAPHL
                     ASPPATPKADKEPLEMTRPPGPPRGPAAATAGYGCPLLSDLTLSPVPRDSLLPLQDTA
                     YRYPGFMPQTHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL"
     misc_feature    <2436..2582
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <2436..2582
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="Domain of unknown function (DUF4683); Region:
                     DUF4683; pfam15735"
                     /db_xref="CDD:464832"
     misc_feature    <3234..3809
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3234..3809
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            5491..6872
                     /gene="Ahdc1"
                     /gene_synonym="RGD1310031"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcagcg gcggcggcgg cggagacgga gagagctcgg agagcagaga aaggcagaga
       61 gagcgagaaa tagagacagg cagacaaaca gacagacaga cagagcggga gggagaaggg
      121 cggcggagga ggagcaggag gactacgcgg ggcgccttcc ctcccagccg ggcgcccgtg
      181 ttgctgtcgc cggcggaaga tagacgcccc ccgaaacccc tcgcttggct cggacccacg
      241 gagccggcag cccagcactc cgatgggagc ttgtctgatt gtctactcat cggcctggac
      301 cccagagcca acccagctga gtgagtgcag agggtcccag gtgaggggca ctgctcaggc
      361 ctgggcagcg actgccctgg agaagctgat ggtggtggag acagaccgtt cctgctgagt
      421 tgggcctcta cagtccctgc tcaggcgctg tccacacccc aaggcctggg ctcaggccga
      481 agttgctcca caataccctc agctgacagc cagcgactgg cagagtcccc aagcacgggg
      541 gccctctgtt taccagagat atccagtgtg acagcccagg cggcagagcc gagggttctg
      601 gtcccggcct ctctcaccct catgtcagcc ccggccccgc ccggcggccc gaggaggaca
      661 aggtcaggat gcgtgtgaag ccccagggcc tggttgtgac ttccagtgcc gtgtgcagct
      721 ctcctgacta cctccgagag cccaagtact accccggcgg ccccccaacc ccccggccct
      781 tgcttcccac ccgcccccct gccagcccac ctgacaaggc cttttccacc cataccttct
      841 ccgagaaccc acgcccaccc ccacgtcggg accccagctc ccggcgtcca ccagtccttg
      901 ccaagggaga cgacctgcta ccccctcggg cagcccggcc tgtctcccag gcccactgtc
      961 ccacaccggc cccagacaac aactccctcc gtcactggga caacgggcgt gtgaacctgc
     1021 atccggtggt gcagctgatt gacatcatga aggacctgac acggctgtcc caggacctgc
     1081 agcacagtgg tgtgcatcta gactgcggcg ggctgcgact gagccgccca cccgctccac
     1141 cgcccggcga cctgcagtac agcttcttct cttcacccag cctggccaat agcatccgca
     1201 gccctgagga gcgtgcgacc cctcacgcca agccagagcg gcccaaccac cccctctatg
     1261 aacctgagcc cgagcccagg gatagtcccc agcctggcca aggccatggt cctggagcca
     1321 cagccacggc cactggtctg cccccagagc ctgagccaga tgggcctgac taccctgagc
     1381 tggcagacgc tgacatcctc agtgaacttg cctcccttac ttgccctgag gcccagctcc
     1441 tggaggctca agcccttgag cctccttcac cacagcctga gccgcagctc ctggaccccc
     1501 agccccgctt cctagaccca caagcactag agcctctagg agaaggtttg gaactaccac
     1561 ccctgcagcc tcttgcggat cctctgggac tgccgagctt gactctgcag gccctagaca
     1621 ccctacctga ctccttggaa tcccagctcc ttgaccctca ggccctcgac cccctgccca
     1681 agttgttgga tgtccctggt cgacgtctag agccccagca atccttggga cactgccaac
     1741 tggctgagcc cttacgcctg gacttgtgct cacctcatgg tccccctggg cctgagggcc
     1801 accccaagta cgccttgagg cgcactgata ggccaaagat cctgtgtcgc aggcggaaag
     1861 ctggaagggg acggaaggtg gattcaggac ctgaaggtcg tctgctgcct cttcccatgc
     1921 ctacagggct ggcagctgcc ctggctgaac ccccaccgct gcccccacca ccaccacctc
     1981 ctgctctgtc aggcccagtt cctgaactgg agccagagtc ctctcaaact ccaatggtcc
     2041 ccacccgcaa aggcaagtgc aggggagtgc ggcggatggt ggtgaagatg gcaaagatcc
     2101 ctgtgtcact agggcggagg aacaagacca cgtacaaagt ttcatccttg agcagcagtc
     2161 tgagtgtgga gggcaaggag ctgggcctga gggtgtcgtc ggagcccacc ccattgctga
     2221 agatgaaaaa caatggccgg aatgtggtgg tggtcttccc gccaggtgag atgcctatta
     2281 ttctcaagcg aaagcgtggc cgccctccta agaacctgct gctgggtcct ggcaaaccca
     2341 aagagccaac agtggtagct gccgaggctg ccgctgtgac agcggccacc atggccatgc
     2401 cggaggtgaa gaaacggcgg cggaggaaac aaaagctggc atccccgcag ccgtcctacg
     2461 cagcagacgc caatgacagt aaggctgagt attccgatgt ccttgccaag ctggcctttt
     2521 tgaaccgcca gagccagtgt gctgggagat gctcgccacc ccgatgctgg acacccagtg
     2581 agcctgagtc agtgcaccaa gccccggaca ctcagagcat ctctcaattc ctgcaccggg
     2641 tgcagggctt ccggaggcgt ggaggcaaga caggaggctt tggaggtagg ggcggaggcc
     2701 atgcagccaa ggcagcccgc tgttccttta gtgacttttt tgagggcatt ggcaagaaaa
     2761 agaaggtggt agcagtggca gctactgggg ttgtgggtcc tggtctcact gagctggggc
     2821 atccacgcaa aaggggccga ggcgaggtag atgctgtaac tgggaaaccc aagcgcaaga
     2881 ggcggtcccg gaagaatggg actctgttcc cagagcaggt gcccagtggc ccaggctttg
     2941 gggaggccgg tgctgagtgg gctggggaca agggtggtgg ctgggcccct caccatgggc
     3001 acccaggagg gcaagctggc cgaaactgtg gtttccaggg gacggaggcc agggcttttg
     3061 cctccactgg gctggagagt ggggcttcag gccgtggcag ctactatgct ggtgcaccct
     3121 caggccagac ggagctcagc caggaacgcc aaaacctctt cactggctat tttcggtccc
     3181 tgcttgattc agatgactcc tctgacctct tggactttgc cctatcggcc tctcgcccag
     3241 agtcccggaa ggcatcgggc aactatgcag ggcctccctc cagtgcgctg cctgctcagc
     3301 gggggcttgc caccttccca agccggggag ccaagggtag cccagtggca gtgggcaaca
     3361 gtggagctgg gacagacccc tccttccagc ctgtcctgcc ttcccgtcag acctttccac
     3421 caggccgggc aacaagctat gggataaccc cagccacttc agactgccga gcagctgaga
     3481 ccttcccaaa gctggctccc cctccttcag ctgtggcccg ctcgcctaca acccaccctc
     3541 ctgccaacac ctacccacct cagtatggtg gctatggggc aggacaaagt gtgtttgccc
     3601 cagcaaagcc cttttcaggc caggactgtg ctaatagtaa ggactgcagc tttgcctatg
     3661 gcagcggcaa tagccttcct gcctcaccca gcagcgccca cagtgctggc tatgccccgc
     3721 cgcctactgg gggtccctgt ctaccgccca gcaaggcctc cttcttcaac agctctgagg
     3781 ggggcccctt ctctgggtca gctcccacac ccttgcgctg tgacagtcga gccagtactg
     3841 tctcacccgg tggctacatg gtacccaagg gcaccacagc ttctgctgcc tctgcggcct
     3901 cctcctcttc ctcttccttt cagccctcac ctgagaactg tcggcagttt gtgggggctt
     3961 ctcagtggcc tttccggcag gggtatggag gcctggactg ggcctcggag gcctttagtc
     4021 agctctacaa tcccaacttt gactgccacg tcagtgaacc caatgtgatc ttggacatct
     4081 cgaactacac gccacagaag gtgaagcagc agactgctgt gtccgagacc ttctccgagt
     4141 catcctctga cagcacccag ttcaatcagc cagttggtgg tggttttagg cgtgccaaca
     4201 gtgaggcctc aagcagtgag ggccagtcaa gcctgtccag cctggagaag ctcatgatgg
     4261 actggaatga agcatcatct gctcccggct acaactggaa ccagagcgtc ctctttcaga
     4321 gtagctcaaa gcctggccgt ggccggcgga agaaggtgga cctgtttgag gcctcacatt
     4381 tgggcttttc aacatccacc tcagccactg cctctgggta tccgtccaaa cggagcaccg
     4441 gaccccggca gcctcggggt ggccggggta gtggggcctg ctcagccaag aaggagagag
     4501 gtggtacagc ggccaaagcc aagttcatcc ccaagccaca accagtgaat ccactgttcc
     4561 aggacagccc agaccttggc ctggactact atagtgggga cagcagcatg tcaccactgc
     4621 cctcccagtc gagagccttt ggtgtgggag aacgagatcc ctgtgacttc atgggacctt
     4681 actccatgaa tccatccaca ccttctgatg gcacttttgg ccaaggcttc cactgtgact
     4741 ctcccagcct gggtgctcct gaccttgaca gcaagcattt cccaccactg gcccacccac
     4801 ccacagtgtt tgatgctggc ctgcagaagg cctactcacc cacctgttca ccgacactag
     4861 gcttcaagga agagttgcgg ccaccacctt caaagctgac tgcctgtgag cccctcaagc
     4921 atggtcttca gggggctagc ctgagtcatg cagcccaggc ccacctgagc tgccgggacc
     4981 taccgctagg ccagcctcac tatgagtccc ctagttgcaa gggtacagcc tattggtacc
     5041 caccaggttc agctgcccgc agcccacctt atgaaggcaa ggtgggttca gggctgctgg
     5101 ctgacttcct gggcaggacg gaggctgtct gcctcagtgc ccctcacctg gctagcccac
     5161 cagccacgcc caaggccgac aaggagccat tggagatgac ccggccccca ggtccacccc
     5221 gtggccctgc tgcagccact gctggctatg gctgcccact ccttagtgac ttaactctgt
     5281 cccctgtgcc gagggactcg ctgctgcccc tgcaggacac tgcctacagg tatccaggct
     5341 ttatgccgca gacacaccct ggcctgggtg ggggtcctaa gagtggcttc ctggggccca
     5401 tggcggaacc tcaccctgag gacacattta ccgtcacctc cctgtagtac caactgaagt
     5461 gccgactgga ccacgaggtt ttgttcctgg ctttcagaag accaatgcca agacccctcc
     5521 cagcgtccac agcatcctct ggcaggagcg cctgcccctc tgcctcccac ctgccccttg
     5581 caccccttgc agccccatat cccacccatg acccctcctt gcccatctcc tccacgcaga
     5641 agccgaaggt gagccctttc tgcacaaaac cagcaattgt aaatactttt taaaatgtac
     5701 aaaacttaaa aacaaaacac agttttagaa aaagacaaaa aaaaaaaaga gagagagagc
     5761 gagagcgaga gagagagcgt gtgcaagagg ttgtgagtgg ggcttcgagg tgtccagagc
     5821 ccctgcaagt gtgcactgag aaatttatct acaggtcgtt tgacaaaaat gaacaatatc
     5881 ctatttattg tatatactgt tttattataa attgtggatt gtatattgca ttctgtaaac
     5941 ctgctgtggt cccgtggtgt gcaaattcgc atggtggggg gggagggaga acctcttttg
     6001 ggggcttttt tttttttttt cttttttttt tttttccttt ttcactcttg ggttttctct
     6061 tctgttgctg ttgttgtttt ttgttggcag gacacaccca aagatccaag tttgtattaa
     6121 aaagaaatga agaaaagcaa aaaaaaaaaa aaaaaaaaaa aaaaaccaac ttgtgtctgt
     6181 aaaacagggt acatgagggt gggtgggact gtactggtga tgtcagcctc tggtccttct
     6241 gggagttgaa gtacctcagg atgttcctgg tttccctacc tctgagtcct ctcatctgcc
     6301 tagtgtctcg gtgtcatctc cgtcccccac cagactccga gtgttttgcc cacatgtatg
     6361 tttgtgcaca gcatgtgtga gttggtgccc ttgaaggtca gaaaagggca tggaatcccc
     6421 gttacagaca gctataagct gtcattccga tgctgggact caaatccatg tcctatgcaa
     6481 gaacagtgag tgttctcaac atcagaaaca ttgcgttgac tcgtccccgc tcctgtccta
     6541 catcccgtgg ctcccacaga tgctttcttt tgcctgaaga gtcccatggt aagtttggtc
     6601 accatcttct tcctctcgat gccctcagtc cacctcaggt cccagagcac caccccgacg
     6661 tctgtttgtc ctgtctccct gaccattaag gctccagact tctatcatgg tcctaagagg
     6721 ccgatcttca ttttactgag gcagagtgtc tctgtgtggc cccagctatc ctagaacttg
     6781 tatgtagtat gtaaaccagg ctgaccagac tcagacctgc ctgcctcatc ttccgagaac
     6841 tgggattaca catgtgccac tgcacccagc aa
//
LOCUS       NM_001437485            7745 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 655 (Zfp655), transcript
            variant 1, mRNA.
ACCESSION   NM_001437485 XM_063271445
VERSION     NM_001437485.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7745)
  AUTHORS   Houlard,M., Romero-Portillo,F., Germani,A., Depaux,A.,
            Regnier-Ricard,F., Gisselbrecht,S. and Varin-Blank,N.
  TITLE     Characterization of VIK-1: a new Vav-interacting Kruppel-like
            protein
  JOURNAL   Oncogene 24 (1), 28-38 (2005)
   PUBMED   15558030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063271445.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR23984936.183657.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000012.1  14488258-14488345   c
            89-251              JAXUCZ010000012.1  14486463-14486625   c
            252-337             JAXUCZ010000012.1  14484730-14484815   c
            338-464             JAXUCZ010000012.1  14484259-14484385   c
            465-569             JAXUCZ010000012.1  14475787-14475891   c
            570-7745            JAXUCZ010000012.1  14467958-14475133   c
FEATURES             Location/Qualifiers
     source          1..7745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..7745
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="zinc finger protein 655"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
     exon            1..88
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            89..251
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="upstream in-frame stop codon"
     CDS             116..1954
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="isoform 1 is encoded by transcript variant 1; vav-1
                     interacting Kruppel-like protein; zinc finger protein
                     205-like"
                     /codon_start=1
                     /product="zinc finger protein 655 isoform 1"
                     /protein_id="NP_001424414.1"
                     /db_xref="GeneID:360764"
                     /db_xref="RGD:1309158"
                     /translation="MEEITSQEAAESPRVQFQSLESQSECLSPELRFLRDTEMEQGYT
                     DAPPVPQVPALPHEGSPGDQAAALLTARYQEFVTFEDVAVHLTREEWGCLDPVQRELY
                     REVMLENYGNVVSLGFPISKPDGISQREQDLQVFDLETQNREGVRNDCSDGETREENK
                     LLIPKRKISEEVHSYKVRVGKFKQDIAQVPETREAYKSEDRLERLQEILRKFLFLERE
                     FRQITISKKTFSNEKNTEPEKSFSLDSTLDTDQRVLRIQTIDDSKYDMNFNQNPAVGE
                     QEPINLTENFQNTDYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQR
                     IHTREKPYKCKECEKSFSQSSSLSRHKRIHTREKSYRCEASDKSCDASDKSCSQSSDV
                     LQHKKVHAKAKSYKCGTCERVFSRSVHLTQHQRTHKDTACKCTVCGSDFCHTSYLVEH
                     QRLHHQEKSYEYDECGLAYVKQQGIRFREKPYSCNECGKDFRLNSHLVQHQRIHTGEK
                     LHECNERGKAFSQTSCLSQHHKMHRKEKSYEYNNYEESFSHNSDLTLQQEVPIRERVF
                     DCDAWEENFSQRAHLIPHERAHTKEKPYECNELGETFSQVQASFNM"
     misc_feature    344..508
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    344..508
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="krueppel associated box; Region: KRAB; smart00349"
                     /db_xref="CDD:214630"
     misc_feature    1037..>1909
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1037..>1909
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1061..1123
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1061..1123
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1076..1078,1082..1084,1088..1090,1094..1099,
                     1106..1111,1118..1120,1265..1267,1271..1273,1283..1288,
                     1295..1300,1307..1309,1349..1351,1355..1357,1361..1363,
                     1367..1372,1379..1384,1391..1393)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1076..1078,1082..1084,1088..1090,1094..1099,
                     1106..1111,1118..1120,1265..1267,1271..1273,1283..1288,
                     1295..1300,1307..1309,1349..1351,1355..1357,1361..1363,
                     1367..1372,1379..1384,1391..1393)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1145..1312
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1145..1312
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1157..1207
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1157..1207
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1334..1396
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1334..1396
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1415..1477
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1415..1477
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1430..1432,1436..1438,1442..1444,1448..1453,
                     1460..1465,1472..1474,1580..1582,1586..1588,1598..1603,
                     1610..1615,1622..1624,1664..1666,1670..1672,1676..1678,
                     1682..1687,1694..1699,1706..1708)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1430..1432,1436..1438,1442..1444,1448..1453,
                     1460..1465,1472..1474,1580..1582,1586..1588,1598..1603,
                     1610..1615,1622..1624,1664..1666,1670..1672,1676..1678,
                     1682..1687,1694..1699,1706..1708)
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1565..1627
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1565..1627
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1649..1711
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1649..1711
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1817..1879
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1817..1879
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            252..337
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            338..464
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            465..569
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
     exon            570..7745
                     /gene="Zfp655"
                     /gene_synonym="RGD1309158; Znf655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcgagagt ggccccggaa aggctggtga gactcagcga ggagcgtctc cgtgacggga
       61 cagtctctag gcccgcctct ccacctggtg atggtcattg tctccctgaa cagggatgga
      121 ggaaataaca tcccaagaag cagcagaatc accaagggtc cagtttcagt ctttggagag
      181 ccagtctgaa tgtctttccc cagagcttcg gtttctgcgg gacacagaga tggagcaggg
      241 atacactgat gctccacctg ttccccaggt gcctgccctt ccccatgagg gaagcccagg
      301 agaccaggca gctgcgctcc tgacagccag gtaccaggag tttgtgacat tcgaggatgt
      361 ggctgtgcat cttactcgag aggagtgggg atgcctggac cctgttcaga gggagctcta
      421 cagagaagtg atgttagaga attatggaaa cgtggtttca ctgggatttc caatttccaa
      481 gcctgatgga atttctcagc gggaacaaga tctacaagtc tttgatctgg aaactcagaa
      541 tagagaaggc gtaagaaatg actgttcaga tggagagacc agagaagaaa acaagctgtt
      601 gattcctaag cggaaaattt cagaagaagt acattcatac aaagtgagag taggaaaatt
      661 caaacaagat attgctcaag ttcctgagac cagagaggct tataagtctg aggacagatt
      721 agaaaggctc caggagattc taagaaaatt tctctttctg gagagagagt ttagacaaat
      781 aacaatcagc aagaaaactt tcagcaatga gaagaacact gaacctgaaa aaagcttcag
      841 tctagactcc acacttgata cagatcaaag agttcttaga atacagacca ttgatgacag
      901 taaatatgac atgaacttca accagaaccc agctgttggc gaacaagaac ccataaatct
      961 aacagagaat tttcagaata ctgactataa ggaaagctta atggatctgt cccaccttaa
     1021 taaatgggag agcatgccta ccactgacag atcctataaa tgtgatacat gtggaaaaac
     1081 cttccatcag gcctcagctc ttactagaca tcagagaatc cacacaagag agaaacccta
     1141 caaatgtaag gaatgtgaga aatcttttag tcagagctca agtcttagtc gacataaaag
     1201 aatacacact agagagaaat cctacagatg tgaagcatct gataaatctt gtgatgcctc
     1261 tgataagtct tgtagccaga gctcagatgt gcttcagcat aagaaggttc atgccaaagc
     1321 caagtcttac aagtgtggga cctgtgaaag agtcttcagc cgaagtgtgc atcttactca
     1381 gcatcagaga acacataagg acacggcctg taaatgcact gtgtgtggca gtgacttctg
     1441 ccacacctca tacttagttg aacatcagag actacatcat caagagaagt cctatgaata
     1501 tgatgaatgt gggctggcct atgttaaaca gcaaggaatt cgtttccgag aaaagcccta
     1561 ctcgtgtaat gaatgtggga aagactttag attgaattcc catcttgttc agcatcaaag
     1621 aattcacaca ggagaaaaac tgcatgaatg taatgagcgt gggaaagctt tcagccagac
     1681 ctcctgcctt agtcagcatc ataaaatgca caggaaagag aaatcatacg aatacaacaa
     1741 ttatgaggaa agtttcagtc acaattctga tcttactctg caacaagaag ttcccattag
     1801 agagagagtc tttgattgtg atgcatggga agagaacttc agtcagagag cgcacctcat
     1861 cccacatgaa agggcgcata ccaaagagaa accttatgaa tgcaatgaac ttggggagac
     1921 gtttagtcaa gttcaggcct cattcaatat gtgagaactg agaccagggg aagtcacata
     1981 tgtactgaat gtgataatgt cttcagtcat agcttagccc ttggtcagta tcagagaatt
     2041 aataccagag agaaacccgc tgaatgtgat gaatattggg aagttttttt ggtgttaaat
     2101 tcttcattgg ctcctgtaaa tcagtgctag aatatataga ctatggtaca ttcttcagat
     2161 tattttcata ccttagtcac agttggggaa tttgtactgg agtaaaattc cactgtcaaa
     2221 tgtgaaaaag ccatcagtca actaccttgt tggttcagtg tcaaatttgt gccatgcata
     2281 aagcctgtga ggatataggt gtgtatgtga ggaaactcaa gtcatacccc agtgcttgct
     2341 cacattgaag aatctaaacc cttgaacagt ctatacccaa gaagtcattt gggtgtagta
     2401 aatgtggcat atctgtgagc acgggtccat ctattgtcag aatgtaccag atgtgaatct
     2461 ggatatgatg taaatgctaa gatcagaaca tctgcaccag atgagactga tagaatgcaa
     2521 acagtgaaat ttaaccactg tattttcagg ccttatccag tatctcaaag tattagaaaa
     2581 tggttactgc tctgtataat tattcctatt tagtctcagt ctttttactg cagaataact
     2641 gaacccagaa gataattggt gaacgaagtc attttctcac agtatccttt aataagtatt
     2701 ctaagtaggt acgagtattt tatttacagg actcctttga gtggatttat tttaattcgg
     2761 cctacataca ttaaaacact tcttttcttt gaaatcgatt cttgttcaca gtttacgtag
     2821 gatgctgcta atgcgctgtg ctcacttagc ttctggagag gagctcaatg agccttctct
     2881 gttcttggcc tgagtgctct ccaaaggaga ctcagcctat tcttttctga ggaccctaca
     2941 tgttactgtt tctgtagcca caccttgggc ttccagttga tttctgcatt ctccttggca
     3001 gccttaaatg gtgttctggt tgttagcttc tcaccagctg ataaagactt acttctacat
     3061 cagccatcca taagttttgg aggattcagt cttcctgagt ttgtggcagg cacccaaaca
     3121 cttgcaagtg atgtccaatt tttagcttgt ttgcatccac agccctttaa atgagatgac
     3181 aaggacatca gggagccagt aagacttatg ttggcctagc tacatttcat tcagtgccta
     3241 ctttgcatgt atgtgtatgt ttagaattct tttatatgcc tatattgaag gccaacaaaa
     3301 tgctcaggtc tgcttttgat agggaaacaa agaacacaca aatcagaata aggaaataga
     3361 gccttccaat gaagatgttg ctgttagtga tgtatctaga cagtatttca agagcgtggc
     3421 aggtccgttc ctggtcaaac cttaatcatt aggattgctt ctttatctgt tccccctcta
     3481 ctcccttcat caagccaggg tagtattttg aagtgtagac ctttgtgcat aattgtttgt
     3541 gcactgccat acttttgtgt tgggatgcag cctttgccgc ccaggctggc cttgaattcc
     3601 tgggttcaca caaatttcct gcctcccaag tagctgggat tataggcatg cgctcctgtg
     3661 cctggatttt atttttgtat tttaatagca tctgcaggcc atttaaagga tcatgtctat
     3721 tttgatttat agaagtgatc acaggtgttg agttcagtgc cctatatact acatagagtt
     3781 catgattctt tacatgatgt caaagcattt gttttcatct taaaataaca tcttgtgaat
     3841 aagaaaagtg ttatttaaaa ttctagttgt caatcaagca gttgaggctt tcatagttca
     3901 gatgtcataa tgttcactag ggatcctcaa ccaatatata aaatatgctg ctcactctgt
     3961 aaaccttgtg gctaacctag gatagggata gtcctaccac tgtattttac ttctttgcca
     4021 tcagcaagca tagtgtctca tcagggcaag aaaattaaca tatatcaaat tgatctaaat
     4081 gtaaaagcaa atgaaaaatg catgtttttc tgtccctgtc aaacatgtat actcttactt
     4141 tatagcgacc aatagtcact tctggtgact gaggcagagg atttgattca tccctaagta
     4201 gcagaatctg taaaaatcac atgtatgcat ttgggttagg aacgtgcttt tgtatttcta
     4261 cttgaataaa ggtgtgttca gcgctcttag actctttgtt ttgaaccaag tctgtaggcc
     4321 ccaggcagaa gctctggcac cttggaattc ttcaccgtgc ctgtccctag ctcctttatg
     4381 atactcacaa gagtgattcg ttctctattg atgcctagct tccctttcca cagacctctg
     4441 cagccagtta ggttgagtag ttttgtattt tagatttaat taaaatgttt atgaatgttt
     4501 gcctgcatgt gcatgtgtgt ctggcattca tagaagacag aagaggacat caggtcccct
     4561 gaaactggag ttagagagac atttgagtgg gttctgaaat cactgctgtt ctctgcaaga
     4621 gcaggcagtg ttcttaactg cggaaccaac tctcaagccc caggaatgaa tgttggttca
     4681 ggtgggatgc tttagtacat aaaataaaat caaacaatgt gtgatttcaa taacgctcta
     4741 agaatgtttt ggtaggtaaa gtaaatttta aaaaagaatg ccaaaatcgt ttttgaagta
     4801 acttgtcagt ttaagtagat acttagttgg tgtagtgaca gtatgagttt gtattaatta
     4861 agcttttggt cttaggggag gaaaagaaga aatctattag ctggacagtt agttcatttg
     4921 tcttcattaa cctgtgtgca tactttcacg tacacattca agctttcacc acagttctgc
     4981 atgagagctt ggcttcgcaa aaggctaaag ggttttagaa caagttaatg tctgatgaaa
     5041 actgattaat ggccgattcc caggtgacag ggtttttgga agcttttcct acggtatcag
     5101 tactgttagc ttcagctgat catactggct tccagagctg atgtcagagt tggtttgatt
     5161 tggtttgaga ccggacatct ctgtatatat ccctgactgt tctggaaccg gctatgtaga
     5221 ccaggctgta gttcacctgc ctcctaagtg tcaccaccac ccagcagaag agagtatctt
     5281 aaagtaatcc gtggacttag ggtaacactg atgtaatgag ttaacaggtc aaaccctcag
     5341 attttctatc tcctgcccag atatccctgc cccatcatta gtttccctgt tcatttctca
     5401 gcattctaaa ttaattctta gctttttctg ttagccaaac tagctgatgg acatagagct
     5461 cttgacctga agcaaaataa ataacaggaa gaagcaagct tgattcctgg ggcatgtgaa
     5521 agaaagactt aaaatgtagg gagccctgga agagtgttag aagaggtaga gtgtccagtg
     5581 cttatgaccg tcttggttag tgttctaatt tagagaagaa aatgtttaac tggaggcttg
     5641 cttacaattt cagaggataa gttcatgatc atcatggccg ggaacatggc tgccggtaag
     5701 accaggcatg taactgagag cttatatcct gatcttcagg caggaggcag aggaattgag
     5761 ctgaaaatgt gcttttaaag tctcaaaact cactcccttc cctcagtgag ataccgccaa
     5821 caaggcctca ttagaatctt ccctaaactg tctacaatca accaaacaat cagatatgtg
     5881 agccctacgg gccattctca ttcaaaccac cacactgaaa acaggatttt tttttttttt
     5941 tttttttttt ttttttaaag acaaggtttc actttactgc cttggctggc ctggaactgt
     6001 gatatgccca cccttgtctc ctaagtgttg ggattaaagg caaggttctt tatgtgtgag
     6061 tgagtgagtg cctgcatgat gtctgtgcgt catgtgcatg caatgtttgt ggaggactag
     6121 atggtgttgg agttcctaga gttactagtc aattgtgaat tgccatggtc ctgtgaattg
     6181 aatgttcatt ttttaaatat tttttttatt ccttgaaaat ttcacacata tgatgctttg
     6241 acaacatgac cattttgtaa gcaatactag gttcttgggc ctatgacctc ccttactgtg
     6301 aacaagtttg cagtagtagg cataaattca catgaagcag cctcagatct aaccagaaag
     6361 tggcaagagt atagcatttt aaagtgggaa taaggggaat ctcgagggga agaatcctta
     6421 ccctagaaaa tggatgtaag cagttgaaca ccctgggtct ccataccaag cttcattagg
     6481 caaatgctat actactaagc tacatttcca tccccaccta ggtctatggt agttaaaagg
     6541 aggccccagt tagtcacttc agcaaagtat gacactgaca cgtctaaaaa tgtagctcca
     6601 cccatcggac ttacctagtt gttaggtgtg tggtattggt gctagccaga gtgacaaact
     6661 gatctaaaat taatccatag atttaagagg actgcgttat taatgcagtg ctttggaagt
     6721 agacatactt aggttttgct caactcaagt gtcacttgag gttttatata acttgcctat
     6781 gcaataaaag catagtgaaa ggtgaatgta ggggttgggg atttagctca gtggtagagc
     6841 gcttgcctag aaagcgcaag gccctgggtt cggtccccag ctccgggggg gggggggggg
     6901 ggaagaacca aaaaaaaaaa aaaaaaaaag gtgaatgtaa aaggtaccag tcaatagcaa
     6961 atgctcagtt agttcagggg ccagtgaagt ggttcactag gtaaggatgc ttgctgccaa
     7021 gcctggtgat cttaatttca tcactgggtt ctacaagtaa ccctttaacc cccacattct
     7081 tgcaatgcac agcacaccaa aatacgaatt tttaaaattt tacattttaa aaagtggtgc
     7141 ttggaagatg gcataagtga ttaagagcat ttctttccag gttcagagcc tgggaaggct
     7201 gacttccatg gtcagtgcac acatgtgata catataggca atacaccata tgcataaatt
     7261 aaatcttttt gttggttttt gtccaagaca gggtcttaat attagctctg gctgtcctgg
     7321 cactcacagt gtagatcagg gaggcctcaa actctcaagt gctgagatta aacgtgtact
     7381 acacacagca agaactgagt ttaaggggct ggagagatgg ttcagccctt aagagtgctg
     7441 actgctcttc cagaggtcct gagttcaatt cccagcaacc acatggtggc tcacaaccat
     7501 ctgtaatgag gtctgatgcc ctcttctggc ctgtaggcgt acatgcaggc agaaagctgt
     7561 atgttgtata cataatattt ttttttgttt tttgtttttt tttggttttt tttttttttt
     7621 ttcggagctg gggaccgaac ccagggcctt gcgcttccta ggtaagcgct ctaccactga
     7681 gctaaatccc cagccccata ttgtttttaa aaaaaaaaaa aaagaactga gtttaagtcc
     7741 cagca
//
LOCUS       NM_001437572            2465 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus lipase, family member K (Lipk), transcript
            variant 1, mRNA.
ACCESSION   NM_001437572 XM_063287436
VERSION     NM_001437572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_063287436.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.6420.1,
                                           SRR22582416.161929.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000001.1  240946106-240946195
            91-172              JAXUCZ010000001.1  240946392-240946473
            173-227             JAXUCZ010000001.1  240948056-240948110
            228-337             JAXUCZ010000001.1  240956749-240956858
            338-455             JAXUCZ010000001.1  240958335-240958452
            456-654             JAXUCZ010000001.1  240959683-240959881
            655-764             JAXUCZ010000001.1  240960695-240960804
            765-901             JAXUCZ010000001.1  240961771-240961907
            902-1048            JAXUCZ010000001.1  240969483-240969629
            1049-1120           JAXUCZ010000001.1  240972105-240972176
            1121-1192           JAXUCZ010000001.1  240974666-240974737
            1193-2465           JAXUCZ010000001.1  240976764-240978036
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2465
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="lipase, family member K"
                     /db_xref="GeneID:294094"
                     /db_xref="RGD:1309724"
     exon            1..90
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..172
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..227
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    197..199
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="upstream in-frame stop codon"
     exon            228..337
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1432
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="lipase-like, ab-hydrolase domain containing 2;
                     lipase K; lipase member K"
                     /codon_start=1
                     /product="lipase member K precursor"
                     /protein_id="NP_001424501.1"
                     /db_xref="GeneID:294094"
                     /db_xref="RGD:1309724"
                     /translation="MWWLLATCCMFLPGPIYGHMQESITNPEANMNISEIISYWGYPY
                     ERHDVVTEDGYILGTYRIPHGKGCSRKAVPKAVVYLQHGLIASASNWICNLPNNSLAF
                     LLADSGYDVWLGNSRGNTWSRKHLRLSPKSPEYWAFSLDEMAKYDLPATINLILEKSG
                     QKQLFYVGHSQGTTIAFIAFSTNPELAKKIRMFFALAPVVTVKYTQSPMKKLTTLSRK
                     AVKILFGDKMFSTHTWLEQFIATKVCNRKLFRQLCSNFLFSLSGFDPQNLNMSRLDVY
                     MAQSPAGTSVQNMLHWAQAVNSGQLQAFDWGNPDQNMMHFNQLTPPVYNISKMRVPTA
                     MWSGGRDVVADEKDTKNLLPKVANLIYYKEIPHYNHMDFYLGQDAPQEVYRDLITMME
                     ESLQN"
     sig_peptide     239..292
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    338..1402
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="triacylglycerol lipase; Region: PLN02872"
                     /db_xref="CDD:215470"
     misc_feature    338..1402
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /note="triacylglycerol lipase; Region: PLN02872"
                     /db_xref="CDD:215470"
     exon            338..455
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..654
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..764
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..901
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1048
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1120
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1192
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..2465
                     /gene="Lipk"
                     /gene_synonym="Lipl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcactgat aggaaactgc ggagggagct ggaatcaatc tgttgctctc tcacaacttg
       61 aagactgaca ctcagaagag ctgagatctg gaaaaaccag atgtgaagag agaggagaga
      121 gagaactact tcagaaggag agaggagacc cagcaactct cctcagagaa agcttttctg
      181 ttgaagaagc ggaaactgat ttgcagagca attaccactg ggaaatagca gactccaaat
      241 gtggtggctt ttagcaacat gttgtatgtt tcttcctgga cccatatatg gccatatgca
      301 agagagcatc acaaatcctg aagccaatat gaacattagt gaaattattt cttactgggg
      361 ctacccttat gaaaggcatg atgttgtaac agaggatggt tatatccttg gaacttaccg
      421 aattcctcat gggaaaggat gctcaaggaa agcagttccg aaggcagttg tgtatctgca
      481 gcatggctta attgcatccg ccagtaactg gatttgcaac ctgcccaaca acagcttggc
      541 ttttcttctg gccgatagtg gttatgacgt gtggttgggg aacagtcgag gaaacacctg
      601 gtccagaaaa cacctgcgac tgtcacctaa gtcaccggaa tactgggcct tcagtttgga
      661 tgagatggct aaatacgatc ttccagctac aatcaatctg atcttagaga aaagtggaca
      721 gaagcaactc ttctatgtgg gccactcgca gggcaccacc atagcgttca tagcattctc
      781 tacgaaccca gagctggcta aaaagatcag aatgtttttc gcgctagctc cagtggtcac
      841 agtaaaatac actcaaagcc caatgaaaaa attaaccacc ctttccagga aagctgtcaa
      901 gatattattt ggtgacaaaa tgttctccac acacacgtgg ctcgaacaat tcattgctac
      961 caaagtgtgc aaccggaagt tattccgtca gctatgcagc aacttcctgt tttctctaag
     1021 tggatttgat ccccaaaact taaacatgag tcgcttggat gtttatatgg cacagagtcc
     1081 tgcaggaaca tctgttcaga acatgttgca ctgggcccag gctgtcaatt ccggtcaact
     1141 ccaagctttt gactggggca atcctgacca gaacatgatg cacttcaacc agcttacccc
     1201 acctgtgtat aacatcagta agatgcgagt cccaacagca atgtggagtg ggggacgcga
     1261 tgttgtggca gatgagaagg acactaagaa cctgctccct aaagttgcca accttatcta
     1321 ctacaaggag atcccacact acaaccacat ggacttttac ctcggacagg acgcccccca
     1381 ggaagtttac cgagacctaa ttacaatgat ggaagagtct ttgcaaaatt aatggcgctc
     1441 tatttttata agcaggtgtg tgtcttgtgg taataataag acagacgctc caatgacacc
     1501 tcagtcattc tcaacttgta ttgtctcttc ttttctgtga ggaagagaac cggagcgagg
     1561 gttctttgta gtcaacagca tttgcaaagt tgacagaggc cataccccct ggctaggtga
     1621 ttctatttgg caaaggtgaa ggaatgcaat tacttccttc attagaaaac acagcattac
     1681 gtttaagaat tctaaagcaa gagctacttt ttttacaaac agatgtaatg aggatgttca
     1741 cattgcaagg aacagcgaat ggtttctcag atctgagaat gatctctggc caataaccag
     1801 caaagatcac ttcaaccact ctaccactgt gcttgagtgc agacccccat tattttgtac
     1861 tcaagcttcc cactgggaaa gcagcctgga ttgcaacctg tgaaacccag ggcagagtcc
     1921 tccatgtata acatgcctac attcttgaac tccaaaacac tggtatcata aatatgcttg
     1981 atttcaaatt gtcaacttta ttctaatctg ttgtcatcaa taataagatg ccaaacctta
     2041 agatatagca agtatataat aaatgtaata cttgatccta ttaactatat agtgacatta
     2101 ataccacaat tgaaagcata taatcttata attatgtaac actgtattac atgtaacaat
     2161 gtatttattg cagtatatta tatgttgtta tttaattggt tgaaaacttg atataacctc
     2221 atcttgattt cacctagtaa cctttgatgt aattctcttc cttgaccatt cagttgtagg
     2281 ttattaatga ctgaattatt cagcatgtat ttagttgaaa aggtctttct gcttttgttt
     2341 ctagaagaat ttatttcctt agaatggaat ttgcattccc atgtttgaat tatgtcattg
     2401 tttttcagtc ttctttttac ttttattctg ctttcatgat taaatcccca ccagtttccc
     2461 ctccc
//
LOCUS       NM_001437472            3690 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            transcript variant 2, mRNA.
ACCESSION   NM_001437472 XM_006254719
VERSION     NM_001437472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3690)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3690)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3690)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3690)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3690)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3690)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254719.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2904200.1,
                                           SRR26360181.1849224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000018.1  48404972-48405181
            211-313             JAXUCZ010000018.1  48472546-48472648
            314-386             JAXUCZ010000018.1  48485845-48485917
            387-1255            JAXUCZ010000018.1  48504584-48505452
            1256-1435           JAXUCZ010000018.1  48507187-48507366
            1436-1549           JAXUCZ010000018.1  48514668-48514781
            1550-1675           JAXUCZ010000018.1  48523111-48523236
            1676-1845           JAXUCZ010000018.1  48526537-48526706
            1846-1938           JAXUCZ010000018.1  48532075-48532167
            1939-2992           JAXUCZ010000018.1  48532658-48533711
            2993-3063           JAXUCZ010000018.1  48534878-48534948
            3064-3690           JAXUCZ010000018.1  48541620-48542246
FEATURES             Location/Qualifiers
     source          1..3690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3690
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..210
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..313
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    218..220
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="upstream in-frame stop codon"
     CDS             257..3148
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     synphilin-1; synuclein, alpha interacting protein
                     (synphilin)"
                     /codon_start=1
                     /product="synphilin-1 isoform 1"
                     /protein_id="NP_001424401.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAM
                     YSSCIHLPSNALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     misc_feature    <1217..1780
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    <1217..1780
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1298..1300,1304..1306,1316..1321,1328..1336,
                     1340..1345,1355..1357,1370..1372,1397..1399,1403..1405,
                     1409..1411,1526..1531,1538..1546,1550..1555,1565..1567,
                     1586..1588,1613..1615,1619..1621,1625..1627,1637..1642,
                     1649..1657,1661..1666,1676..1678,1685..1687,1712..1714)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(1298..1300,1304..1306,1316..1321,1328..1336,
                     1340..1345,1355..1357,1370..1372,1397..1399,1403..1405,
                     1409..1411,1526..1531,1538..1546,1550..1555,1565..1567,
                     1586..1588,1613..1615,1619..1621,1625..1627,1637..1642,
                     1649..1657,1661..1666,1676..1678,1685..1687,1712..1714)
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1298..1399
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1298..1399
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1403..1615
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1403..1615
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1619..1714
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1619..1714
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1787..1918
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     misc_feature    1787..1918
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="Synphilin-1 alpha-Synuclein-binding domain; Region:
                     SNCAIP_SNCA_bd; pfam16700"
                     /db_xref="CDD:435527"
     exon            314..386
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1255
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1435
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1549
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1675
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1845
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1938
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2992
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3063
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3690
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtcgcg tccctgatct caacgtcccg ctgccccggg tgtccccgcc cgcgcgcgcc
       61 cgttgggggg cccggggtgc ggcgccggcc gccgggccgc attgtgacgt agcggggccg
      121 cggcagcgcc tccgccgccc gccggggtct cctgcgcccg ccgctctcgc cgtctgtccg
      181 tccatccctc ccgccgccct tcccgctccg gatattataa atattcgacc ttactcaaaa
      241 tgtacaaaga agaataatgg aagcccctga atatcttgat ctggatgaaa tcgactttag
      301 tgatgacatt tcttattcag tcacatctct caagaccatc ccagcactgt gcagaagatg
      361 tgactcacag aacgaagaca gaccagtttc tagctctagc tggaattgtg gtgtctcaac
      421 tctcattaca aacccgcaaa agcccactgg aatcgctgat gtatacagta agttccgccc
      481 ggtgaagcga gtttctccac tgaaacatca gccagagact ctggagagca atgaaagtga
      541 cgaccagaag aacaatacag tggaatacca gaaagggggg gagactgacc agggccccca
      601 gcctgaggag ctcagccctg aagatggagt cggaggcttg ccaggcaagg gctcagagcc
      661 cagccaggca ctgggtgagc tggagcacta tgacctcgac atggatgaga ttctggatgt
      721 gccttacatt aaatccagtc aacagctggc cccgctcacc aaggtgactt cagaaaaaag
      781 gattttgggt ttatgcacaa ctgtcaatgg cctctctgcc aaaacctgcc ctattgtaag
      841 cgctgagacc tccacaccca acatggctcc attgtgtgtt ctttctcctg tgaaaagccc
      901 tcacttacgg aaagtaccca gtgtcctccg ggaccagcac aagctccctg cggaagaatc
      961 ggagaactca cccgctcctg gtaaatgcgg ccctgcattt gaatcagaaa accacagtaa
     1021 ggacttctta aacaaggtct ttagtgatcc ccatagtcgg aaagctgaga agtctgggcc
     1081 agactgcaag ctcaggccct tccgcctgca gacctcggca gcaggagcca aaccagagga
     1141 gcaggtcaac ggcgtgagct gggccagtgc ccaaggcgca gaagaaagga ctgagtacct
     1201 gcagaaagta agaagcatac tgaacattgt gaacgaaggg cagatatcgc tcttgccaca
     1261 cctagctgca gataatctgg acaaaattca cgacgagaac ggaaacaatc tgttacacgt
     1321 tgctgcatca aagggccatg cggaatgtct gcagcacctc acgtcgctga tgggcgaaga
     1381 ctgtctgaat gaacggaacg cagagcaact gactccagcg ggcctggcca tcaagaatgg
     1441 tcagctggag tgtgtacgct ggatggtgag tgagacggaa gccattgcgg aactgagttg
     1501 ttccaaggat ttcccaagcc taattcatta cgcaggctgc tatgggcagg aaaagattct
     1561 tctgtggctt cttcagttca tgcaagaaca aggcatctca ttggatgaag tagatcagga
     1621 aggcaacagt gctgttcatg tcgcttcaca acatggctac cttggatgca tacagaccct
     1681 ggtggagtat ggagcaaatg ttacgatgca gaaccacgct ggggaaaagc cctcccagag
     1741 tgccgagcgg cacggccaca ccctatgttc ccggtacctc gtggtggtag agacctgtat
     1801 gtcactggcc tcacaagtgg taaagttgac caagcagcta aaggagcaga cagtggagcg
     1861 cgtcacactg cagagtcaac tccaacaact tctggaagcc cagaaatcag agggcaagtc
     1921 cctcccatct tcacccagtt caccctcctc accagcttct agaaagtccc agtggaaaat
     1981 tctagatgca gatgacgagt ctacaggcaa aagcaaactg ggaacccagg agggaataca
     2041 agtccttgga aacttatcca gcagggctag gaccaaagga aaagacgaag actctgataa
     2101 aatcctacgt cagttattgg ggaaagaaat atcagagaat gtctgcaccc aggaaaagct
     2161 gtcattggaa ttccaggatg ctcaggtatc ctctaggaat tcgaaaaaaa tacctctaga
     2221 gaagagggaa ctgaagctag ctagactgcg gcagctgatg cagagatctt tgagtgaatc
     2281 tgacacggat tcaaacaact ctgaggaccc caaaaatact cctgtgaaaa gagtggacag
     2341 acctagacca cagcccattg tggaaagtgt ggagaatatg gacagtgcag aaagcttaca
     2401 cctgatgata aagaaacact ctgtggcatc aggacgcagg tttccttttg gtatgaaggc
     2461 ctccaaatcc ctggatgggc acagcccatc tcccacttca gagagcagtg aaccagattt
     2521 ggactcccat tgcccgagcc tgggaatgac tcctccaacc caaccttcta cagaagccac
     2581 tcagtgcagt cctgacagtg ccactgccca gaaagttgct acaagcccca agagtgccct
     2641 caagtctcca tcatccaagc gccggacatc ccaaaactca aaactgagag tgacctttga
     2701 ggagcctgtt gtgcaaatgg agcaaactag ccttgaacta aatggagaaa aagacaaaga
     2761 gaggggcagg gccccccaga ggactagtga gtcaggagaa caaatgaaaa ggccttttgg
     2821 aaccttccga tccatcatgg agagtttaag tggtaatcag aacaacaata ataactacca
     2881 gccagccagc cagctgaaga cctgcacact acccttgacg tcacttggaa ggaagacagc
     2941 agatgccaag ggaaaccctg tgagccctgc tagcaaagga aagaataagg cagcgatgta
     3001 cagcagctgc attcatcttc cctctaatgc gctggtcgaa gagcatctgc gtgattatgc
     3061 acggcttaat gacatcaaaa gaaacacgaa gaaaacttac aacgtaaagc acattgctga
     3121 accagagcca aaggaactct tcttataaat tactcttagt atgagtctca cacatgccct
     3181 ctggccacca ttgggagtta atggactgtg gcaatcagac catgagaaca acacctcacc
     3241 agcgagcaga atatctggat gccttaaatt tataatatga gacttgttat aagatacatt
     3301 ttggaccata tctgtacata gaacttgttt gatttctttt ttaatatgct gtttgaaaac
     3361 atgatcgggc aatgtatgca ttgacacatt ggacatttga ttgagtcgac cttcttgaag
     3421 cacatccacc agcacctgac acgactagtg tttttgtgaa ttgcatgagg atttgctgat
     3481 gttgattaga tgttcacctt ctttgtaaca agggcagctg tggctcagct cagtgaggcc
     3541 aggtcactgg ttttattttc tgtccagtgt gtttttctgt catttctact tttttaataa
     3601 agaaaattaa acatttgtaa cagcagactc tgggcgtggg gggcagggca tctactttct
     3661 aataaatctg tgaagctctg atttctaaaa
//
LOCUS       NM_001109125             440 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 475 (Zfp475), mRNA.
ACCESSION   NM_001109125 XM_001057605 XM_039097044 XM_574151
VERSION     NM_001109125.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Apr 2, 2025 this sequence version replaced
            XM_039097044.1, NM_001109125.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR460939.1, SRR26643293.77353.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000018.1  48276175-48276261
            88-268              JAXUCZ010000018.1  48294264-48294444
            269-440             JAXUCZ010000018.1  48297391-48297562
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..440
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc finger protein 475"
                     /db_xref="GeneID:498866"
                     /db_xref="RGD:1564428"
     exon            1..87
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    46..48
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="upstream in-frame stop codon"
     exon            88..268
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..420
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc finger protein 474"
                     /codon_start=1
                     /product="zinc finger protein 475"
                     /protein_id="NP_001102595.1"
                     /db_xref="GeneID:498866"
                     /db_xref="RGD:1564428"
                     /translation="MIRRPPTVVCYICGREYGTKSISIHEPQCLKKWHNENNLLPKEL
                     RRPEPRKPEIRTIAAKGFYDLDALNDAAWTSAQSQLVPCNLCGRTFLPDRLIVHQRSC
                     KPKASK"
     misc_feature    109..180
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc-finger of a C2HC-type; Region: zf-C2HC_2;
                     pfam13913"
                     /db_xref="CDD:464037"
     misc_feature    109..180
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc-finger of a C2HC-type; Region: zf-C2HC_2;
                     pfam13913"
                     /db_xref="CDD:464037"
     misc_feature    328..402
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc-finger of a C2HC-type; Region: zf-C2HC_2;
                     pfam13913"
                     /db_xref="CDD:464037"
     misc_feature    328..402
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /note="zinc-finger of a C2HC-type; Region: zf-C2HC_2;
                     pfam13913"
                     /db_xref="CDD:464037"
     exon            269..440
                     /gene="Zfp475"
                     /gene_synonym="RGD1564428; Znf474"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctttcctt ggggccaacc atgcccgcat atcagggcag catcctagga tcccgtggct
       61 ctcaggtgtt caaagagcaa caataagcca acgatgataa ggcgtccacc gacagttgtt
      121 tgttacatct gtggccgtga atatgggacc aaatctatta gcatccatga gccacaatgt
      181 ctgaaaaagt ggcataatga gaacaatttg ttacctaaag agctaagaag accagaaccc
      241 aggaaaccag aaatcagaac cattgccgcc aaaggattct acgatcttga cgccttaaat
      301 gacgccgctt ggacaagtgc ccagagccaa ttggttccct gcaacctttg tgggcggacc
      361 ttcctgccag acagactaat tgttcaccag cgatcttgta aacccaaagc ctccaagtaa
      421 agccctttcc tcagcatcaa
//
LOCUS       NM_001107139            6957 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol transfer protein,
            membrane-associated 2 (Pitpnm2), transcript variant 2, mRNA.
ACCESSION   NM_001107139 XM_001079124 XM_063271306 XM_222155
VERSION     NM_001107139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6957)
  AUTHORS   Lu,C., Vihtelic,T.S., Hyde,D.R. and Li,T.
  TITLE     A neuronal-specific mammalian homolog of the Drosophila retinal
            degeneration B gene with expression restricted to the retina and
            dentate gyrus
  JOURNAL   J Neurosci 19 (17), 7317-7325 (1999)
   PUBMED   10460238
REFERENCE   2  (bases 1 to 6957)
  AUTHORS   Lev,S., Hernandez,J., Martinez,R., Chen,A., Plowman,G. and
            Schlessinger,J.
  TITLE     Identification of a novel family of targets of PYK2 related to
            Drosophila retinal degeneration B (rdgB) protein
  JOURNAL   Mol Cell Biol 19 (3), 2278-2288 (1999)
   PUBMED   10022914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_063271306.1, NM_001107139.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               JAXUCZ010000012.1  38008179-38008537
            360-460             JAXUCZ010000012.1  38041755-38041855
            461-637             JAXUCZ010000012.1  38104755-38104931
            638-852             JAXUCZ010000012.1  38114915-38115129
            853-974             JAXUCZ010000012.1  38116367-38116488
            975-1202            JAXUCZ010000012.1  38117712-38117939
            1203-1502           JAXUCZ010000012.1  38121825-38122124
            1503-1598           JAXUCZ010000012.1  38122990-38123085
            1599-1703           JAXUCZ010000012.1  38124853-38124957
            1704-1774           JAXUCZ010000012.1  38125120-38125190
            1775-2022           JAXUCZ010000012.1  38127459-38127706
            2023-2212           JAXUCZ010000012.1  38128142-38128331
            2213-2332           JAXUCZ010000012.1  38128491-38128610
            2333-2571           JAXUCZ010000012.1  38129454-38129692
            2572-2750           JAXUCZ010000012.1  38130083-38130261
            2751-2921           JAXUCZ010000012.1  38131413-38131583
            2922-3086           JAXUCZ010000012.1  38133165-38133329
            3087-3235           JAXUCZ010000012.1  38134760-38134908
            3236-3352           JAXUCZ010000012.1  38135164-38135280
            3353-3469           JAXUCZ010000012.1  38135579-38135695
            3470-3618           JAXUCZ010000012.1  38135773-38135921
            3619-3768           JAXUCZ010000012.1  38136037-38136186
            3769-3952           JAXUCZ010000012.1  38136681-38136864
            3953-4081           JAXUCZ010000012.1  38136960-38137088
            4082-6957           JAXUCZ010000012.1  38137171-38140046
FEATURES             Location/Qualifiers
     source          1..6957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..6957
                     /gene="Pitpnm2"
                     /note="phosphatidylinositol transfer protein,
                     membrane-associated 2"
                     /db_xref="GeneID:304474"
                     /db_xref="RGD:1310867"
     exon            1..359
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..460
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..637
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    470..472
                     /gene="Pitpnm2"
                     /note="upstream in-frame stop codon"
     CDS             560..4405
                     /gene="Pitpnm2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     membrane-associated phosphatidylinositol transfer protein
                     2"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 2 isoform 2"
                     /protein_id="NP_001100609.1"
                     /db_xref="GeneID:304474"
                     /db_xref="RGD:1310867"
                     /translation="MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGQGSGVEILE
                     NRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCP
                     FVEKFSIDIETFYKTDTGENNNVFNLSPVEKNQLITDIIDIVKDPVTPSEYKTEEDPK
                     LFQSIKTRRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRR
                     VMVRAHRQAWCWQDEWYGLTMEKIRELEKEVQLMLSRKMAQFSEEGPSELSKESTIKD
                     QATGATPEPSSSNGESLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDS
                     DESSEEEFFDAQENLQHKEEMYTKDITKWSSNDLMDKMENPEPEESQDSLYHQSGSEF
                     RVASSVEQLNTIEDEVSQPLATPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTIT
                     NVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPL
                     AALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFD
                     ALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGILVNAAHCSGGSGGGSGGGSSLESS
                     RHLSRSNIDIPRSNGTEDSRKQMPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPS
                     SRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQ
                     VYNLFHPADPSASRLEPLLERRFHTLPPFNIPRYQRYPLGDGCSTLLADALQTHNTVF
                     QEHAAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASGIAQIAAKWWGQKRIDYA
                     LYCPDALMAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSASILELDGKEVSVFTP
                     SQPREKWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVD
                     VHIMTQPPSGEWLYLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYI
                     TVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDM
                     QKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDV
                     AVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMA
                     LRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDLEQRGQRSMSMAAS
                     CWGRAMAGRLEPGAATGPK"
     misc_feature    560..1333
                     /gene="Pitpnm2"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); Region:
                     SRPBCC_PITPNM1-2_like; cd08889"
                     /db_xref="CDD:176898"
     misc_feature    560..1333
                     /gene="Pitpnm2"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); Region:
                     SRPBCC_PITPNM1-2_like; cd08889"
                     /db_xref="CDD:176898"
     misc_feature    order(620..625,632..634,644..646,653..655,677..679,
                     734..736,740..742,746..748,752..754,761..763,767..769,
                     776..778,788..790,800..805,809..811,815..817,821..823,
                     827..829,842..844,848..850,854..856,863..868,884..886,
                     890..892,1133..1135,1151..1153,1157..1159,1187..1189,
                     1211..1219,1226..1228)
                     /gene="Pitpnm2"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176898"
     misc_feature    order(620..625,632..634,644..646,653..655,677..679,
                     734..736,740..742,746..748,752..754,761..763,767..769,
                     776..778,788..790,800..805,809..811,815..817,821..823,
                     827..829,842..844,848..850,854..856,863..868,884..886,
                     890..892,1133..1135,1151..1153,1157..1159,1187..1189,
                     1211..1219,1226..1228)
                     /gene="Pitpnm2"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176898"
     misc_feature    752..808
                     /gene="Pitpnm2"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    752..808
                     /gene="Pitpnm2"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    order(911..1000,1016..1090,1115..1120)
                     /gene="Pitpnm2"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    order(911..1000,1016..1090,1115..1120)
                     /gene="Pitpnm2"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     misc_feature    1049..1051
                     /gene="Pitpnm2"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]; other site"
                     /db_xref="CDD:176898"
     misc_feature    1049..1051
                     /gene="Pitpnm2"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]; other site"
                     /db_xref="CDD:176898"
     misc_feature    2660..3241
                     /gene="Pitpnm2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    2660..3241
                     /gene="Pitpnm2"
                     /note="DDHD domain; Region: DDHD; pfam02862"
                     /db_xref="CDD:460725"
     misc_feature    3677..4072
                     /gene="Pitpnm2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; Region: LNS2;
                     smart00775"
                     /db_xref="CDD:197870"
     misc_feature    3677..4072
                     /gene="Pitpnm2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; Region: LNS2;
                     smart00775"
                     /db_xref="CDD:197870"
     exon            638..852
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..974
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1202
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1502
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1598
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1703
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1774
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2022
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2212
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2332
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2571
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2750
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2921
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3086
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3235
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3352
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3469
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3618
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3768
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3952
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4081
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..6957
                     /gene="Pitpnm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgactgagg gaatgcgagc cgggccggcg cgcgcgggag gcagcggccg ctgaggcgcg
       61 tgggggcacg gcggcgccgc ggctcagagc gctccagccg gcccggcccg cgtcccctca
      121 gcccgcgctc acagaggcca cagcggccgg cggtccgagt cgcgcgccag cacgtgcgct
      181 gccgccgacg gcccggagca tgcccgccgc cgtccggacg ctcgcgcggg gccagctggc
      241 ggcgggggcg cgcgggtcca cggggtgcag ccggcccggc cggggccgtg gggcccgcgc
      301 tgcccgggac gcggcgtgag gcggcggcca aggagcccgg agcgcggccc gccgagcggg
      361 atgctggcac gtgtgtcttg gtccctgact cccttctgtg gacatactga tcattcctcc
      421 tcctgtggtg gagacgttga cagagctgct cagatctaag ggtcttcagt gaattctgtc
      481 atggttattt aaggaatctt gcctagaaag tccccacaag cacgaagtcc cctgccgccc
      541 agaaggcgtg gactccaaga tgatcataaa ggaataccgg attcccctgc caatgactgt
      601 ggaggaatac cgcatcgccc agctgtacat gatacagaag aagagccgga acgagaccta
      661 tggacaaggc agcggagtgg agatcctgga gaaccgaccc tacacagatg gtcctggggg
      721 ctccgggcag tacacccaca aggtgtatca tgtgggcatg cacattcctg gctggtttcg
      781 ctccatcttg cccaaagcag ccttgcgggt ggtggaggag tcctggaacg cctaccccta
      841 cacccgaaca aggttcacct gcccctttgt ggagaagttc tccattgaca ttgaaacctt
      901 ttataagaca gacactgggg aaaacaataa tgtgttcaac ctgtctcctg tggaaaagaa
      961 ccagctgata acagacatca tcgacatcgt caaggatcct gtgaccccca gtgagtacaa
     1021 gacagaagaa gaccccaagc tcttccagtc gatcaagact cgccggggac ctctctctga
     1081 aaactggatt caggagtaca agaagcggct cctccccatc atgtgcgcct acaagctctg
     1141 taaggtggag ttccggtact ggggcatgca gtccaagatc gagaggttta tccatgacac
     1201 aggcttgcgg cgggtgatgg tgagggccca ccggcaggcc tggtgctggc aggacgaatg
     1261 gtatgggctg accatggaga aaatccgaga gctggagaag gaggtacagc tcatgctgtc
     1321 ccgcaaaatg gcccagtttt cggaggaagg accatcagaa ctaagcaagg agagtacaat
     1381 caaggaccag gcaactggag caactcctga acccagcagc agcaatgggg agtctctggg
     1441 gcggggtctg aagaagcagt ggtccacctc ctccaagtcc tcaaggtcct ccaagcgcgg
     1501 agccagcccc tcccggcata gcatctcaga gtggagaatg cagagtatcg ccagggactc
     1561 tgacgaaagc tcagaagaag agttcttcga tgcacaagaa aacctgcagc acaaggagga
     1621 aatgtacacc aaggacatca ccaagtggag ctccaatgac ctcatggaca aaatggagaa
     1681 tccagagcct gaggaatcac aggactctct ctaccaccag agtggctctg agttcagggt
     1741 ggcctccagt gtggagcagc tgaacaccat cgaggatgag gtgagccagc cactagccac
     1801 accaccctcc aagattcacg tgctgctgct ggtgctgcat ggaggcacta tcctggacac
     1861 gggagcgggt gaccccagct ccaagcaggg tgacaccaac actatcacca atgtgttcga
     1921 caccgtcatg cgtgtgcact accccagtgc cctaggccac ctagccatcc gcctggtgcc
     1981 ctgcccaccc atctgtgccg atgccttcgc cctcgtctcc aacctcagtc cctatggcca
     2041 tgatgagggc tgtctgtcta gcagccagga ccacatcccc ctggctgctc tgcccctgct
     2101 ggccacttcc tcaccccagt accaggaggc agttgctaca gtgattcagc gggccaacct
     2161 ggcctatgga gactttatca agtcccagga aggcgtgacc ttcaacggac aggtctgcct
     2221 gattggagac tgtgtcgggg gcattctggc gtttgatgcc ttgtgctaca gtggccagcc
     2281 agtgtctgag agccagagca gtagccgccg gggcagtgtg gtcagcatgc aggacgctga
     2341 cctgctgtcc ccgggcatcc tggtgaatgc agcacactgc tccggtggta gtggcggtgg
     2401 cagtggtgga ggctccagcc tggagagcag ccggcatctg agccgtagca acattgacat
     2461 cccccgaagc aacggcacgg aggactccag aaagcagatg cctcgcaaaa ggagcgactc
     2521 ctccacctat gagctggaca ccatccagca gcaccaggcc ttcctgtcca gcctccatgc
     2581 cagcgtactg aggaatgaac ccagctcccg ccgctcaagc agttccacga tgctggacgg
     2641 tgccggggcc ctgggcaagt ttgacttcga gatcgccgac ctcttcctct tcgggtgccc
     2701 actggggcta gtcctagcct tgaggaaaac agtcatcccc tccctggatg ttttccagct
     2761 gcggccagcg tgtcagcaag tgtacaacct cttccaccct gcggaccctt cagcctcccg
     2821 cctggaaccg ctgctggagc ggcgtttcca caccctgccg cccttcaaca tccctcgata
     2881 ccagcgctac ccgctggggg atggctgttc cacactgctg gcggatgcgc tccagaccca
     2941 caacacagtc ttccaagagc atgcagcccc ctcgtcaccc ggcacagccc ctgctagccg
     3001 tggcttccgc agagccagtg agatcagcat cgccagtcag gtgtcaggca tggcggagag
     3061 ctacacagca tccggcattg cccagattgc tgccaagtgg tggggccaga agcggattga
     3121 ctacgccctg tactgccccg acgccctcat ggccttcccc acagtggccc tgccccacct
     3181 cttccatgcc agctactggg agtcaaccga tgtggtctcc tttctgctga gacaggtcat
     3241 gcggcacgac agcgcgagca tcctagagct ggacggcaag gaggtgtccg tgttcacgcc
     3301 ttcgcagccc agggagaagt ggcagcgcaa gagaacccac gtgaagctcc ggaacgtggc
     3361 agccaatcac cggatcaatg atgcagttgc caatgaggac ggcccacagg ttgtgacagg
     3421 ccggttcatg tacgggccct tagacatggt caccctgact ggggaaaagg tggatgtgca
     3481 catcatgacg cagccgccct caggtgagtg gctgtaccta gacactctag tgaccaacag
     3541 cagtgggcgt gtctcctaca cgattccaga aacacaccgc ctgggggtgg gcgtgtaccc
     3601 tatcaagatg gtggtcaggg gagaccacac atttgccgac agctacatca ctgtgctccc
     3661 caagggcaca gagtttgtgg tcttcagtat cgatggctcc tttgcggcta gcgtgtccat
     3721 catgggcagc gaccccaagg tgcgcgccgg ggctgtggac gtggtgcgac actggcagga
     3781 cctgggctac ctcatcatct atgtgaccgg ccggccggac atgcagaagc agcgggtggt
     3841 ggcatggctg gctcagcaca atttccctca cggtgtggtg tccttctgtg atggcctggt
     3901 gcacgacccg ctgcgccaca aggctaactt tctgaagctg ctcatctctg agctgcacct
     3961 gcgcgcgcat gcggcctacg gctccaccaa ggatgtggcc gtctacaact ccatcagcct
     4021 ttctcccatg cacatctaca ttgtgggccg ccccaccaag aagttgcagc agcagtgtca
     4081 gttcatcaca gacggctacg cggcccacct ggcccagctc aagtacaatc accgggcgcg
     4141 gccagcgcgg aacacagcaa cgcgcatggc tttgcgcaag ggcagcttcg gtctgcctgg
     4201 ccaaggtgac ttccttcgct cccggaatca cctgctccgc accatctcgg ctcagcccag
     4261 tgggcccagc catcggcacg atcggacaca gacccagatg gacttggagc agcggggcca
     4321 gcgcagcatg agcatggcgg ccagttgctg gggccgtgcc atggcaggcc ggcttgaacc
     4381 cggggcagcc acaggaccca agtaggaccc cctcaggagg cgctgtggtc tccatggtgc
     4441 taggccaggg caccggccct cctgggcaca cgtaggtggc tggggacaca gacaggacct
     4501 gagagcttgt cccggggcct cttggaagac agccatgcca acccagtcct cccagccttg
     4561 cccaatgccc taggctctga ggagcccagc tagtcatgga aactggcagg aggtccagcc
     4621 catgacggaa gaggaaccag gatcggccac ttagcccagc ctgggaggca ttcctggacg
     4681 tcttgctctg tgttgatctc tcagcctcct ggtggcaggc atgggtcttg gccttgcctg
     4741 tcacctccct gtccactggc gccccttccc atttggcagc agctccaatg gggtctaacc
     4801 tgcttcttgt tgactccagt tttcaactgt ccaacctcac tggttttgca ctggtttttg
     4861 agagtggaga cccgttacca cctcctggct ccagacatgt tgacatgcat gaaaatccag
     4921 tctctgctga tccagggcct gtcaccacac agaatattcc agtgtggaaa gttttcacgc
     4981 aagcaggaga gaaaggccat accttagttt ctgctgcctg cctgggctgc cgacaccaca
     5041 gcagcccgat ggcagtccca gactgctacc cacctgtcca cctgccccac ccagagctca
     5101 gtgcagtccc agagccgatg tcactccggg ccctgagcac agcacaggtg tgaggccagg
     5161 aaagtgcacg gctggctctt cgtagcccac cttgggcagc tggacctgaa gaggcctggc
     5221 ctccacctct actcctcgcc ggccatgggc ggggaccccg tgccatggct gctgcccacc
     5281 gtgtttctac gcctttctac ttctccatcc ggtttctata aggttttttt taacaggcaa
     5341 tcctgggctg cttccttttc ttaactcagt gtcagcgcag cctgctacat taggaacacc
     5401 cagcactgtg acagggtccc actcagtctg gcctgtgggc cctgcacctg gcccacttgg
     5461 caaggtgtgg gtttcttgcc tcacctgacc cacaattcca ccgacttcct actctggtgt
     5521 gggtggggct cttaggtttt cttaatgcca ttctgtttta atgtcgactc caagaagcca
     5581 cagctcacat gtcagcctga gggcgtacag ccattttatt tctctccaaa caaggatggg
     5641 catcttacac gctgggtctg ggccctgcct tccgcacagc actgaccacg accctactgc
     5701 accttctgtg ttggctgagc tcacggagct caggcctcct gtccagtgac ggggctctgc
     5761 ttgagtagct gccaagctgg actcagactc agggccccgt ggctgggtca agaggcgtat
     5821 aggagacact gactttgctg tgtagttacg tacagcacag gggcgtggga ttcccgccac
     5881 ggccggtcta cacgggaaga aagctattta ttttgtgcag aggaaaaaaa aatgtctgga
     5941 ggggtgaggc cttcagggtc tcctcatcca tgtagctttg tgctgttccc agcgttctgt
     6001 ataaagcagt gattatctta tggaccaaga ttccatggag ctgtcacggt aaaagtgcaa
     6061 tatttgcccc accactccca caggaagctg ctggcccgac aatcactgcc ccattgcggg
     6121 caccaggggc cagggcctcc tccctcaggc cccccgtctt gcctcagctg aggtgactag
     6181 ccatcgggag aagcacctag aagcctcagg ccacttgcag tcaaggcaag ggaggtcctg
     6241 gggtcagtgg gcttggtccc tcccctgggc agccccctgt ggctctgaat gcccatgctt
     6301 gcccagccgc cagccatgcc aaggacaaca gcaatagtcc cctgggctct cccagggccc
     6361 tcagccatag atggtgagac gggcagcctt ccccaaaacc tcactcaagt ctgctttttg
     6421 cctccctcga gattcccttt ggctcattct cttgaggaag ccccactttt acagaaagta
     6481 agagaggaag gtcaaagtcc tttaaaaata ccaaaaaaat gtttacagtg tcaggtgctg
     6541 agctgcaggg ctcaggcctg gccattcgta accaaagggt gaggcagacc ttgctgactg
     6601 ccacccaccc caggcctgtt agaatagaag ccttagtcag tccctccccg tccccagtcc
     6661 ccaggactga gccttgatgc cacccaacac caaccacctg ccttctctta gatttctgaa
     6721 gaaggattca gcaaagccca tccccttcct ggctctgtgt gagctagcca ccattctacc
     6781 ctgttttacc ttcacatctc agacacctcc catctttgtc cttgtactgt ctgttcctct
     6841 ggaccattgt gtgaactgtc ctgacccccc atgctgtccc tgcatcgtct ggcctgagtg
     6901 tgctctctgt atactgtgtc acagtctgtt acaccaatta aagaagcagg aggcttc
//
LOCUS       NM_001437514            5162 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus LDL receptor related protein 5 (Lrp5), transcript
            variant 1, mRNA.
ACCESSION   NM_001437514 XM_063286724
VERSION     NM_001437514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5162)
  AUTHORS   Ubels,J.L., Lin,C.M., Antonetti,D.A., Diaz-Coranguez,M.,
            Diegel,C.R. and Williams,B.O.
  TITLE     Structure and function of the retina of low-density lipoprotein
            receptor-related protein 5 (Lrp5)-deficient rats
  JOURNAL   Exp Eye Res 217, 108977 (2022)
   PUBMED   35139333
  REMARK    GeneRIF: Structure and function of the retina of low-density
            lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
REFERENCE   2  (bases 1 to 5162)
  AUTHORS   Ju,S., Lim,L., Wi,K., Park,C., Ki,Y.J., Choi,D.H. and Song,H.
  TITLE     LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in
            Ischemic Myocardium
  JOURNAL   Int J Mol Sci 22 (12), 6581 (2021)
   PUBMED   34205318
  REMARK    GeneRIF: LRP5 Regulates HIF-1alpha Stability via Interaction with
            PHD2 in Ischemic Myocardium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5162)
  AUTHORS   Ubels,J.L., Diegel,C.R., Foxa,G.E., Ethen,N.J., Lensing,J.N.,
            Madaj,Z.B. and Williams,B.O.
  TITLE     Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats
            Have Reduced Bone Mass and Abnormal Development of the Retinal
            Vasculature
  JOURNAL   CRISPR J 3 (4), 284-298 (2020)
   PUBMED   32833527
  REMARK    GeneRIF: Low-Density Lipoprotein Receptor-Related Protein
            5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of
            the Retinal Vasculature.
REFERENCE   4  (bases 1 to 5162)
  AUTHORS   Ergun,S.G., Akay,G.G., Ergun,M.A. and Percin,E.F.
  TITLE     LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated
            microphthalmia
  JOURNAL   Eur J Med Genet 60 (3), 200-204 (2017)
   PUBMED   28111184
REFERENCE   5  (bases 1 to 5162)
  AUTHORS   Huang,W., Li,Q., Amiry-Moghaddam,M., Hokama,M., Sardi,S.H.,
            Nagao,M., Warman,M.L. and Olsen,B.R.
  TITLE     Critical Endothelial Regulation by LRP5 during Retinal Vascular
            Development
  JOURNAL   PLoS One 11 (3), e0152833 (2016)
   PUBMED   27031698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5162)
  AUTHORS   Kato,M., Patel,M.S., Levasseur,R., Lobov,I., Chang,B.H., Glass,D.A.
            2nd, Hartmann,C., Li,L., Hwang,T.H., Brayton,C.F., Lang,R.A.,
            Karsenty,G. and Chan,L.
  TITLE     Cbfa1-independent decrease in osteoblast proliferation, osteopenia,
            and persistent embryonic eye vascularization in mice deficient in
            Lrp5, a Wnt coreceptor
  JOURNAL   J Cell Biol 157 (2), 303-314 (2002)
   PUBMED   11956231
REFERENCE   7  (bases 1 to 5162)
  AUTHORS   Gong,Y., Slee,R.B., Fukai,N., Rawadi,G., Roman-Roman,S.,
            Reginato,A.M., Wang,H., Cundy,T., Glorieux,F.H., Lev,D.,
            Zacharin,M., Oexle,K., Marcelino,J., Suwairi,W., Heeger,S.,
            Sabatakos,G., Apte,S., Adkins,W.N., Allgrove,J.,
            Arslan-Kirchner,M., Batch,J.A., Beighton,P., Black,G.C.,
            Boles,R.G., Boon,L.M., Borrone,C., Brunner,H.G., Carle,G.F.,
            Dallapiccola,B., De Paepe,A., Floege,B., Halfhide,M.L., Hall,B.,
            Hennekam,R.C., Hirose,T., Jans,A., Juppner,H., Kim,C.A.,
            Keppler-Noreuil,K., Kohlschuetter,A., LaCombe,D., Lambert,M.,
            Lemyre,E., Letteboer,T., Peltonen,L., Ramesar,R.S., Romanengo,M.,
            Somer,H., Steichen-Gersdorf,E., Steinmann,B., Sullivan,B.,
            Superti-Furga,A., Swoboda,W., van den Boogaard,M.J., Van Hul,W.,
            Vikkula,M., Votruba,M., Zabel,B., Garcia,T., Baron,R., Olsen,B.R.
            and Warman,M.L.
  CONSRTM   Osteoporosis-Pseudoglioma Syndrome Collaborative Group
  TITLE     LDL receptor-related protein 5 (LRP5) affects bone accrual and eye
            development
  JOURNAL   Cell 107 (4), 513-523 (2001)
   PUBMED   11719191
REFERENCE   8  (bases 1 to 5162)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   9  (bases 1 to 5162)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   10 (bases 1 to 5162)
  AUTHORS   Dong,Y., Lathrop,W., Weaver,D., Qiu,Q., Cini,J., Bertolini,D. and
            Chen,D.
  TITLE     Molecular cloning and characterization of LR3, a novel LDL receptor
            family protein with mitogenic activity
  JOURNAL   Biochem Biophys Res Commun 251 (3), 784-790 (1998)
   PUBMED   9790987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063286724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.4351.1,
                                           SRR26643297.4157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000001.1  210346652-210346861 c
            211-607             JAXUCZ010000001.1  210318557-210318953 c
            608-805             JAXUCZ010000001.1  210309785-210309982 c
            806-1002            JAXUCZ010000001.1  210307819-210308015 c
            1003-1134           JAXUCZ010000001.1  210306078-210306209 c
            1135-1531           JAXUCZ010000001.1  210292353-210292749 c
            1532-1703           JAXUCZ010000001.1  210290549-210290720 c
            1704-1920           JAXUCZ010000001.1  210284473-210284689 c
            1921-2210           JAXUCZ010000001.1  210282092-210282381 c
            2211-2437           JAXUCZ010000001.1  210276939-210277165 c
            2438-2622           JAXUCZ010000001.1  210275260-210275444 c
            2623-2946           JAXUCZ010000001.1  210273195-210273518 c
            2947-3146           JAXUCZ010000001.1  210270805-210271004 c
            3147-3355           JAXUCZ010000001.1  210265970-210266178 c
            3356-3546           JAXUCZ010000001.1  210264664-210264854 c
            3547-3756           JAXUCZ010000001.1  210263254-210263463 c
            3757-3882           JAXUCZ010000001.1  210259181-210259306 c
            3883-4119           JAXUCZ010000001.1  210255963-210256199 c
            4120-4230           JAXUCZ010000001.1  210253209-210253319 c
            4231-4467           JAXUCZ010000001.1  210250960-210251196 c
            4468-4607           JAXUCZ010000001.1  210250220-210250359 c
            4608-4705           JAXUCZ010000001.1  210246692-210246789 c
            4706-5162           JAXUCZ010000001.1  210243507-210243963 c
FEATURES             Location/Qualifiers
     source          1..5162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42-q43"
     gene            1..5162
                     /gene="Lrp5"
                     /note="LDL receptor related protein 5"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
     exon            1..210
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..4967
                     /gene="Lrp5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor-related
                     protein 5"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     5 isoform 1 precursor"
                     /protein_id="NP_001424443.1"
                     /db_xref="GeneID:293649"
                     /db_xref="RGD:1309329"
                     /translation="METAPTRAPPPPPQPLLLLLALCCSLVPAAASPLLLFANRRDVR
                     LVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNI
                     VISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP
                     AHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF
                     IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILS
                     ALYSPMDIQVLSQERQPHFHTPCEEGNGGCSHLCLLSPREPFYSCACPTGVQLQDNGK
                     TCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDD
                     EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
                     KILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGL
                     ALDLQEGKLYWGDAKTDKIEVINIDGTKRQTLLEDKLPHIFGFTLLGDFIYWTDWQRR
                     SIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATK
                     CGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDF
                     DVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTN
                     RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT
                     LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSD
                     YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCG
                     QLCLAIPGGHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLILP
                     LHGLRNVKAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLS
                     IDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQD
                     HAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANR
                     LTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAV
                     EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD
                     QFACATGEIDCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDGE
                     ADCQDGSDEANCDAVCLPNQFRCASGQCVLIKQQCDSFPDCADGSDELMCEINKPPSD
                     DVPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGTPHVPLN
                     FIAPGGSQHGPFPGIPCSKSMMSSVSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLY
                     PPILNPPPSPATDPSLYNMDMFYSSNIPSTARPYRPYIIRGMAPPTTPCSTDVCDSDY
                     STSRWKTSKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPVTERSYCHLFPPPPSP
                     CTDSS"
     sig_peptide     120..212
                     /gene="Lrp5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    186..761
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    186..761
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    423..545
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    423..545
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    606..728
                     /gene="Lrp5"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    606..728
                     /gene="Lrp5"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:459654"
     misc_feature    678..806
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    678..806
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    807..932
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    807..932
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1014..1127
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1014..1127
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1215..1337
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1215..1337
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1341..1469
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1341..1469
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1470..1601
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1470..1601
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1602..1730
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1602..1730
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1731..1832
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1731..1832
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    1932..2039
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    1932..2039
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    <2079..2465
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    <2079..2465
                     /gene="Lrp5"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; Region: YncE; COG3391"
                     /db_xref="CDD:442618"
     misc_feature    2247..2375
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2247..2375
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2514..2633
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2514..2633
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2631..2756
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2631..2756
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    2835..2942
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    2835..2942
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3027..3146
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3027..3146
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3297..3428
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3297..3428
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3429..3557
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3429..3557
                     /gene="Lrp5"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:214531"
     misc_feature    3768..3878
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3768..3878
                     /gene="Lrp5"
                     /note="Coagulation Factor Xa inhibitory site; Region:
                     FXa_inhibition; pfam14670"
                     /db_xref="CDD:464251"
     misc_feature    3894..4004
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    3894..4004
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(3909..3911,3939..3941,3972..3977)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3909..3911,3939..3941,3972..3977)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(3951..3953,3960..3962,3972..3974,3990..3995)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(3951..3953,3960..3962,3972..3974,3990..3995)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    3981..3995
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    3981..3995
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4011..4115
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    4011..4115
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(4026..4028,4050..4052,4083..4088)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4026..4028,4050..4052,4083..4088)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4062..4064,4071..4073,4083..4085,4101..4106)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(4062..4064,4071..4073,4083..4085,4101..4106)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    4092..4106
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4092..4106
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4125..4229
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    4125..4229
                     /gene="Lrp5"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:238060"
     misc_feature    order(4140..4142,4164..4166,4197..4202)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4140..4142,4164..4166,4197..4202)
                     /gene="Lrp5"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     misc_feature    order(4176..4178,4185..4187,4197..4199,4215..4220)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    order(4176..4178,4185..4187,4197..4199,4215..4220)
                     /gene="Lrp5"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:238060"
     misc_feature    4206..4220
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     misc_feature    4206..4220
                     /gene="Lrp5"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:238060"
     exon            211..607
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            608..805
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1002
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1134
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1531
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1703
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1920
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2210
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2437
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2622
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2946
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3146
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3355
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3546
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3756
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3882
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4119
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4230
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4467
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4468..4607
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4705
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..5162
                     /gene="Lrp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttgggcc gcggcgcccg aggcgggagc aagaggcgcc gggagccgcg agggtccacc
       61 gccgccgcgc gcgccatgga gcccgagtga gcgcgcggcg ctcccggccg ccggacgaca
      121 tggaaacggc gccgacccgg gcccctccgc cgccgccgca gccgctgttg ctgctgctgg
      181 cgctgtgctg cagcctagtc cccgctgcgg cctcaccact cctgttgttt gccaaccgcc
      241 gggatgtacg actagtggat gctggtggag tgaagctgga gtccaccatt gtggccagtg
      301 gtctggagga cgcagctgct gtagacttcc agttctccaa gggtgctgtg tactggacag
      361 atgtgagcga ggaggccatc aaacagacct acctgaacca gactggagct gctgcacaga
      421 acattgtcat ctctggcctt gtatcacctg atggcctggc ctgtgactgg gttggcaaga
      481 agctgtactg gacagactca gagaccaacc gcatcgaggt ggccaacctc aatgggacgt
      541 cccgtaaggt tctcttctgg caggacctgg accagccaag ggccattgcc ctggatcctg
      601 cacatgggta catgtactgg actgactggg gggaagcacc ccggatcgag cgggcaggga
      661 tggatggcag tacccggaag atcattgtag actccgacat ttactggccc aatgggctga
      721 ccattgatct ggaggagcag aagctgtact gggctgatgc caaactcagc ttcatccacc
      781 gtgccaacct ggacggctcc ttccggcaga aggtggtgga gggcagcctc actcacccct
      841 ttgccctgac actctctggg gacacactct actggacaga ctggcagacc cgttctatcc
      901 acgcctgcaa caagtggaca ggggagaaaa ggaaggagat cctcagtgct ctgtattcac
      961 ccatggacat tcaggtgctg agccaggagc ggcagcctca cttccacacg ccatgtgagg
     1021 aaggcaacgg cggctgctcc cacctgtgcc tgctgtcccc gagggagccc ttctactcct
     1081 gcgcctgccc tactggtgta cagttgcagg acaatggcaa gacgtgtaag gcaggggctg
     1141 aggaagtgct gctgctggcc cggaggacag acctgagaag gatctctctg gacacccctg
     1201 acttcacaga catagtgctg caagtgggcg acattcggca tgccatcgcc atcgactatg
     1261 acccactgga gggctacgtg tactggacag atgacgaggt gcgggctatc cgcagggcgt
     1321 acctggatgg ctcaggtgcg cagacccttg tgaacaccga gatcaatgat cccgatggca
     1381 ttgccgtgga ctgggtcgcc cggaacctct actggacaga tacaggcact gacagaattg
     1441 aggtgactcg cctcaacggc acctcccgaa agatcctggt gtccgaggac ctggacgaac
     1501 ctcgagccat tgtgttgcac cctgtgatgg gcctcatgta ctggacagac tggggagaga
     1561 accccaaaat cgaatgtgcc aacctagatg ggcgagatcg gcatgtcctg gtgaacacct
     1621 cccttgggtg gcccaatgga ctggccctgg acctgcagga gggcaagctg tactgggggg
     1681 atgccaaaac tgataaaatt gaggtgatca acatagacgg gacaaagcgg cagaccctgc
     1741 tagaggacaa gctcccgcac atttttgggt tcactctgct tggggacttc atctactgga
     1801 cagattggca gcgacgcagt attgagaggg tacacaaggt caaggccagc cgggatgtca
     1861 tcatcgatca actccccgac ctgatgggac tcaaagcagt gaacgtggcc aaggttgtcg
     1921 gaaccaaccc gtgtgcggat ggaaatggag ggtgcagcca tctgtgcttc ttcaccccac
     1981 acgccaccaa gtgcggttgc cccataggcc tggagctgct gagtgacatg aagacctgta
     2041 taatccctga agccttcctg gtgttcacca gcagagccac catccacagg atctccctgg
     2101 agactaacaa caatgacgtg gccatcccgc tcaccggtgt caaggaggcc tctgcactgg
     2161 actttgatgt gtccaacaac cacatctact ggactgatgt cagcctcaag actatcagcc
     2221 gagccttcat gaatgggagc tcagtggagc acgtgattga gtttggcctc gactaccctg
     2281 aaggaatggc cgtggattgg atgggcaaga acctctattg ggctgacacg gggaccaaca
     2341 ggattgaggt ggcccgactg gatgggcagt tccggcaggt gctggtgtgg agagaccttg
     2401 acaaccccag gtcgctggct ctggatccta ctaaaggcta catctactgg accgagtggg
     2461 gaggcaagcc aaggatcgtg cgggccttca tggatgggac caattgtatg acactggtag
     2521 acaaggtggg ccgggccaat gacctcacca ttgattacgc cgaccagcga ctgtactgga
     2581 ctgacctgga caccaacatg attgagtcct ccaacatgct gggtcaggag cgcatggtga
     2641 tagctgatga tctgccctac ccctttggcc tgactcaata tagcgattac atctactgga
     2701 ccgactggaa cctgcatagc attgaacggg ccgacaagac cagcgggcgg aaccgtaccc
     2761 tcatccaggg tcacctggac ttcgtcatgg acatcctggt gtttcactcc tcccgtcagg
     2821 atggcctcaa cgactgcgtg cacagcaatg gccagtgtgg gcagctgtgc ctcgccatcc
     2881 ctggaggcca ccgctgcggc tgtgcttccc actacacgct ggaccccagc agccgcaact
     2941 gcagcccgcc ctccaccttc ttgctgttca gccagaaatt tgccatcagc cggatgatcc
     3001 ccgatgacca gctcagtccg gaccttatcc tacccctaca cgggctgagg aatgtcaaag
     3061 ccatcaacta cgacccgctg gacaagttca tctactgggt ggatgggcgt cagaacatca
     3121 agagggccaa ggacgacggt acccagccct ccatgctgac ctctcccagc caaagcctga
     3181 gcccagaccg acagccacat gacctcagca ttgacatcta cagccggaca ctgttctgga
     3241 cctgtgaggc caccaacacc atcaatgtcc accggctgga tggggatgcc atgggagtgg
     3301 tgcttcgagg ggaccgtgac agaccaaggg ccattgctgt caatgctgag cgagggtaca
     3361 tgtactttac caacatgcag gaccatgctg ccaagattga gcgagcctcc ctggatggca
     3421 cggagcgtga ggttctcttc accaccggcc ttatccgtcc tgtggccctt gtggtggaca
     3481 atgccctggg caagctcttc tgggtggatg cagacctaaa gcgcattgaa agctgcgacc
     3541 tctcaggggc caaccgcctg accctggaag atgccaacat cgtgcagcca gtaggtctga
     3601 cggtgctggg gaggcacctc tactggatcg accgccagca gcagatgatt gagcgtgtgg
     3661 agaagaccac tggggacaag aggactaggg ttcagggccg tgtcacccac ctgacaggca
     3721 tccatgctgt ggaggaagtc agcctggagg agttctcagc ccatccttgt gcccgagaca
     3781 atggcggctg ctcccatatc tgcatcgcca agggtgatgg gacaccgcgc tgctcatgcc
     3841 cagtccacct cgtgctcctg cagaacctgc tgacttgtgg tgagcctcct acctgctccc
     3901 ctgatcagtt tgcatgtgcc actggtgaga ttgactgcat ccctggagcc tggcgctgtg
     3961 acggcttccc tgagtgtgct gaccagagtg atgaggaagg ctgcccagtg tgctctgcct
     4021 ctcagttccc ctgtgctcga ggccagtgcg tggacctgcg tttacgctgc gatggtgagg
     4081 ctgactgcca ggatggctcg gatgaagcta actgcgatgc tgtctgtctc cccaatcagt
     4141 tccggtgcgc cagtggccag tgcgtcctca tcaagcagca gtgcgattcc ttccccgact
     4201 gtgctgatgg atctgatgag ctcatgtgtg aaatcaacaa gccaccttct gatgacgtac
     4261 cagcccacag cagcgccatt gggcctgtca ttggcatcat cctgtccctc ttcgtcatgg
     4321 gcggggtcta ctttgtctgc cagcgtgtga tgtgccagcg ttacacaggg gccagtggtc
     4381 cctttcccca cgagtatgtt ggtggaaccc ctcatgtgcc tctcaacttc atagccccag
     4441 gtggctcaca gcacggtccc ttcccaggca tcccgtgcag caagtccatg atgagttctg
     4501 tgagcctggt gggggggcgg ggcagcgtgc ccctctatga ccggaatcac gtcaccgggg
     4561 cctcatccag cagttcatcc agcacaaagg ccacactcta tccaccgatc ctgaacccac
     4621 caccgtcccc ggccacagac ccctccctgt acaacatgga catgttttat tcttcaaaca
     4681 tcccatccac tgccagacca tacaggccct acatcattcg aggtatggca cccccaacaa
     4741 caccttgcag cacagacgtg tgtgacagcg actacagcac cagtcgctgg aagaccagca
     4801 agtactacct ggacttgaat tcggactcag acccctaccc gcccccgccc actccccaca
     4861 gccagtacct gtctgcagag gatagctgtc caccctctcc tgtcactgag agaagctact
     4921 gccacctctt cccaccccct ccatccccct gcacggactc gtcctgacct cggccgtcca
     4981 ccccggcctc gctgcctccc tgtaaatatt tttaaatatg aacaaaggaa aaatatattt
     5041 tatgatttaa aaaataaata taattgggat ttttaagaag tgagaaatgt gagcggtgaa
     5101 ggggtgggca gggctgggaa aactttgtac agtggagaaa atatttataa acttaatttt
     5161 tt
//
LOCUS       NM_001437446            1799 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus testis-specific serine kinase substrate (Tsks),
            transcript variant 4, mRNA.
ACCESSION   NM_001437446 XM_006229017
VERSION     NM_001437446.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Xu,B., Hao,Z., Jha,K.N., Zhang,Z., Urekar,C., Digilio,L.,
            Pulido,S., Strauss,J.F. 3rd, Flickinger,C.J. and Herr,J.C.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Kueng,P., Nikolova,Z., Djonov,V., Hemphill,A., Rohrbach,V.,
            Boehlen,D., Zuercher,G., Andres,A.C. and Ziemiecki,A.
  TITLE     A novel family of serine/threonine kinases participating in
            spermiogenesis
  JOURNAL   J Cell Biol 139 (7), 1851-1859 (1997)
   PUBMED   9412477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006229017.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1295640.1,
                                           SRR26643293.2993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  104564050-104564264
            216-438             JAXUCZ010000001.1  104564592-104564814
            439-534             JAXUCZ010000001.1  104570948-104571043
            535-618             JAXUCZ010000001.1  104571207-104571290
            619-702             JAXUCZ010000001.1  104572249-104572332
            703-989             JAXUCZ010000001.1  104572931-104573217
            990-1184            JAXUCZ010000001.1  104574234-104574428
            1185-1358           JAXUCZ010000001.1  104574810-104574983
            1359-1494           JAXUCZ010000001.1  104576616-104576751
            1495-1619           JAXUCZ010000001.1  104577708-104577832
            1620-1799           JAXUCZ010000001.1  104577968-104578147
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1799
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="testis-specific serine kinase substrate"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
     exon            1..215
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1776
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="isoform 4 is encoded by transcript variant 4; STK22
                     substrate 1; testis-specific kinase substrate;
                     serine/threonine kinase 22 substrate 1"
                     /codon_start=1
                     /product="testis-specific serine kinase substrate isoform
                     4"
                     /protein_id="NP_001424375.1"
                     /db_xref="GeneID:292890"
                     /db_xref="RGD:727784"
                     /translation="MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAK
                     GITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTE
                     DSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQ
                     TLQSECSVLSENLERRRQEAEELEGYCSQLKENCRKVTRSVEDAEIKTNVLKQNSALL
                     EEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEP
                     PRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQE
                     ALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLR
                     SELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQ
                     LLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQD
                     EAVRAKNLLLTDKMKPEEKVATLDYMHLKMCSLHDQLSHLPLEGSTGAMGGGSTGGAP
                     PKRGGPGSEQ"
     misc_feature    187..1773
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    187..1773
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Testis-specific serine kinase substrate; Region:
                     TSKS; pfam15358"
                     /db_xref="CDD:434661"
     misc_feature    316..423
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    469..>792
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Growth-arrest specific micro-tubule binding;
                     Region: GAS; pfam13851"
                     /db_xref="CDD:464001"
     misc_feature    688..690
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    802..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    859..861
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    943..945
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60531.1); phosphorylation site"
     misc_feature    1693..1773
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /note="propagated from UniProtKB/Swiss-Prot (P60531.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            216..438
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..534
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..989
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1184
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1358
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1494
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1619
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1799
                     /gene="Tsks"
                     /gene_synonym="Stk22s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtagatg gtgagtctcc ccctgggagc aggccccccc gcgccatggc aagcgtggtg
       61 gtgaagacaa tctggcaatc caaagagatc cacgaagcgg gggacccacc tgcgggggtg
      121 gagagccgcg cccagctggt ccccgaagct cccggggggg tgaccagccc tgccaagggg
      181 ataacaaaga aaaagaaggc cgtgtccttc catggggtgg agccccggat gtcccacgag
      241 ccgatgcact ggtgcctgaa cctcaagcgg tcctcagcct gcaccaacgt gtccttgctc
      301 aacctggctg ccatggagcc cgactcctcc ggtacagact cgaccacaga ggacagtggt
      361 ccactggcac tgccagggcc acctgcttcc cctacaacac cctgggctcc agaggaccct
      421 gacatcacag aactactgag tggggtcaac agtggattgg tacgtgccaa agactccatc
      481 accagcttga aggaaaagac cacgcgggtt aatcagcatg ttcagacact gcagagcgag
      541 tgctctgtgc tgagtgagaa tctggaaaga aggcggcagg aggcagaaga gttggagggg
      601 tactgcagtc aattgaagga gaactgccgc aaggtgaccc gttcagtgga agacgctgaa
      661 atcaaaacca atgtcctgaa gcagaactct gccttgttgg aggagaagct aagatacctc
      721 cagcagcaac tgcaggatga gacgccccgg agacaggagg ccgagttgca ggagctggag
      781 caaaaactag aggctggcct ctcccggcat ggcctaggcc ctactactcc cattcagggc
      841 tgctccggtc ctcctggtag cccggaggaa cccccgcggc cgcgaggcct gccctccaat
      901 ggctggggca tggcaatccg cgcaggggag ggaccctcgc tgagcgagca ggagttgcag
      961 aaggtctcca gcggcctaga ggagctgagg agggaggtgt cctcgctggc agctcggtgg
     1021 catcaggagg agggggcggt gcaggaggcc ctaaggttgc tgggaggcct gggcggccgt
     1081 ctggatggct ttctgggcca atgggagcgg gcgcagcggg aacaagcaca gtccgcacgg
     1141 ggtttgcagg agctgcgagg acgagcagat gagctgtgca ctatggtgga gaggtcagca
     1201 gtgtctgtcg cttcactgag gagcgaactg gaggcactgg gcccagtaaa accgattctg
     1261 gaggagctgg gacggcaact tcaaaactcc cgaaggggac ctgaccatgt cttgaacttg
     1321 gatcgtcctg cccaaggtcc ctgtcctcga tgtgccagcc aggggcagca gttatccacg
     1381 gagtccctac agcagctgct ggaacgtgcg ctgaccccac tggtggacga agtgaagcag
     1441 aagggtctgg ctcctgcctg ccccagttgc cagaggctac acaagaagat tctggagctg
     1501 gagcgccagg ccttggccaa acacgtcagg gcagaggccc tgagctccac ccttcggctg
     1561 gcccaagacg aagccgttcg ggccaagaac ctactgctga cggacaagat gaagccggag
     1621 gagaaggtgg ccactttgga ctatatgcat ttgaagatgt gttccctcca cgaccaactc
     1681 agccacctgc cacttgaggg gtccacaggg gcaatggggg gaggaagcac tggaggggct
     1741 ccccctaaac gtgggggtcc aggctctgaa caataaatgg cctctcatgc tggcatgaa
//
LOCUS       NM_001106241            2102 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus Ras and Rab interactor-like (Rinl), transcript
            variant 1, mRNA.
ACCESSION   NM_001106241 XM_001078499 XM_218477
VERSION     NM_001106241.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2102)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001106241.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1641.1,
                                           SRR26643284.532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  93204794-93204825
            33-155              JAXUCZ010000001.1  93206409-93206531
            156-315             JAXUCZ010000001.1  93206696-93206855
            316-418             JAXUCZ010000001.1  93209713-93209815
            419-491             JAXUCZ010000001.1  93211848-93211920
            492-556             JAXUCZ010000001.1  93212006-93212070
            557-703             JAXUCZ010000001.1  93212633-93212779
            704-1180            JAXUCZ010000001.1  93212866-93213342
            1181-1468           JAXUCZ010000001.1  93213660-93213947
            1469-1600           JAXUCZ010000001.1  93214110-93214241
            1601-1764           JAXUCZ010000001.1  93214371-93214534
            1765-2102           JAXUCZ010000001.1  93214620-93214957
FEATURES             Location/Qualifiers
     source          1..2102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2102
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
     exon            1..32
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            33..155
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1809
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     and Rab interactor-like protein"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein isoform 1"
                     /protein_id="NP_001099711.1"
                     /db_xref="GeneID:292760"
                     /db_xref="RGD:1310133"
                     /translation="MRLAQPDMVSAATTEEARLSWPLAEGADKSPLRVLSTTESLLRL
                     QRTQRVWQVPELDAEHAKAFLKPWPLGSFLVIGQDPDQVLMLKTGPSSGDINTYQIQK
                     FPGGVSLESSNLCMPDFPHLLAFLSASRDVLPRTLLLPTPTVGPGDKHSDPRRLGCIQ
                     VDTSGRVLSVVNQLYLETHGGWETETPQQTKPETGQKRSLAPRMPTPHRVSWVEESLK
                     PEAHHTGQEVHHPERQVHYPGPEAHSLGPEVHFPSPVLEEEEEVNNDSYKDEEEGCED
                     MLTAHIRALASARSSYVARQYQCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQD
                     YLAKDPDVRAVFGNRGPSIPREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELR
                     RLRRRQIALRVGAGPEGQSPALRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLA
                     GGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWF
                     GALYHIAHYQPDAGRAPQELSSEARASLRQWHRRRTLHQQAQPTAPENQPFEEPWAIG
                     DP"
     misc_feature    229..510
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    229..510
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    order(274..276,328..330,391..393,397..399)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(274..276,328..330,391..393,397..399)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(394..396,475..477)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    order(394..396,475..477)
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    1351..1659
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     misc_feature    1351..1659
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /note="Vacuolar sorting protein 9 (VPS9) domain; Region:
                     VPS9; pfam02204"
                     /db_xref="CDD:460489"
     exon            156..315
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            316..418
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            419..491
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            492..556
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            557..703
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1180
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1468
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1600
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1764
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2102
                     /gene="Rinl"
                     /gene_synonym="RGD1310133"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgct gctcaggctc ccctcggaac agctggagca gccttgagtc ttgtcttcct
       61 ccatgccaga ggccaaagca tggctcactg gtgcctggca gcatgaggct agcccagccg
      121 gacatggtgt ctgcagccac tactgaagag gccaggctga gttggccact agcagaagga
      181 gcagacaaga gcccactgag ggtcctcagc acgacagagt cacttcttcg actgcagagg
      241 acacagaggg tgtggcaggt ccccgagctg gacgctgagc atgccaaggc ctttctcaag
      301 ccgtggccac tggggagctt cctggtcatc gggcaggacc ctgaccaggt cctgatgttg
      361 aagacaggac cttcgtcagg agatatcaac acctaccaaa ttcagaagtt tcctggaggt
      421 gtgtccctgg aatcctccaa cctctgcatg ccagactttc ctcatctcct ggcctttctg
      481 tcagccagca gggacgtttt gccaaggact ctgctcttgc ccacacctac tgtggggcct
      541 ggagataagc actcagatcc tcgtcgactt ggctgcatcc aggtggacac ctcagggagg
      601 gtgctgtctg tggtgaacca gctctacctg gagacccatg gaggctggga aacagaaaca
      661 ccgcagcaaa caaagccaga aactggccag aaacgcagtc tagcccccag gatgcccact
      721 ccacaccggg tctcctgggt ggaagagtct ctgaaaccgg aagctcacca tactggacag
      781 gaagtgcatc atccagaaag acaagtgcat tatcctggac cagaagctca ctctcttggg
      841 ccagaagtac actttcctag tcctgttcta gaagaggagg aagaagtgaa caatgacagc
      901 tacaaggatg aagaggaagg ctgcgaggat atgctcactg cccacatccg tgctctggcc
      961 agtgcccgga gcagttatgt agccaggcag taccaatgcc ttcgagcacg actcatctca
     1021 gattctggaa atccctacag cccaggggac ccagccacag agctgcttca ggatgtacgc
     1081 cagctcctca ctgacctcca ggattacctg gcaaaagacc ccgatgtcag agctgtcttt
     1141 gggaataggg gacctagcat ccctcgggaa gaagatcttg gccccgctgt ggaggtggcc
     1201 ctgtgtcgag cggttctgga gcccctgaag cccgccctgt ggaccaaact ccgaactctc
     1261 agagcccagg aactgcggcg actgcgccgg cgccaaatag ccttgagggt aggagcagga
     1321 cccgagggac agagcccggc cttgcggaac cgtatccacg cacgcctcgc tcacctgcac
     1381 gcagcgtgcg ccccgcgccg caaggtggcg ctgttgttgg cggtgtgcag cgatgtctat
     1441 gcaggcctgg ctggcggcga gaataaagag cccctggggg ctgacgcctt tttacctgcc
     1501 ctgaccgagg agctgatctg gagtccacat attggggaaa cacagctgga tgtggagttt
     1561 cttatggagc tcttggatcc aggggagttg cgaggagaag ctgggtatta tcttaccacg
     1621 tggtttgggg ctctctacca cattgctcac taccagcctg atgctggccg tgcaccccag
     1681 gagctcagct ctgaggcccg ggcctccttg cgccagtggc accgaagacg gacactgcac
     1741 cagcaagccc agcccacagc cccggaaaac cagccctttg aggagccatg ggcaataggg
     1801 gacccatgat gattggagtc ctcaaaaatc agtctccaga accttttggc ccactcctct
     1861 gctaagcaag attctggagg catctgggtc agcacagtgg gtggggcaga aaaaaggacg
     1921 tggcgttttg cactggctgt tcctacttcc ttccttcccc tcctggtctg tccacatgtt
     1981 acctcaatga ggctctcccc agcaaacaaa accaacgcct aaacaatact acaactacag
     2041 ccctctcacc tgaatctctc tggggcaggt agaataaagg cacagtcccc aaaaggtatc
     2101 ta
//
LOCUS       NM_001436947            2552 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus nescient helix loop helix 1 (Nhlh1), transcript
            variant 2, mRNA.
ACCESSION   NM_001436947 XM_063272130
VERSION     NM_001436947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Manetopoulos,C., Hansson,A., Karlsson,J., Jonsson,J.I. and
            Axelson,H.
  TITLE     The LIM-only protein LMO4 modulates the transcriptional activity of
            HEN1
  JOURNAL   Biochem Biophys Res Commun 307 (4), 891-899 (2003)
   PUBMED   12878195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 24, 2025 this sequence version replaced XM_063272130.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1155514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16418971
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               JAXUCZ010000013.1  87054622-87054933   c
            313-415             JAXUCZ010000013.1  87053670-87053772   c
            416-2552            JAXUCZ010000013.1  87049735-87051871   c
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2552
                     /gene="Nhlh1"
                     /note="nescient helix loop helix 1"
                     /db_xref="GeneID:289230"
                     /db_xref="RGD:1310261"
     exon            1..312
                     /gene="Nhlh1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..415
                     /gene="Nhlh1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..2552
                     /gene="Nhlh1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    439..441
                     /gene="Nhlh1"
                     /note="upstream in-frame stop codon"
     CDS             586..987
                     /gene="Nhlh1"
                     /codon_start=1
                     /product="helix-loop-helix protein 1"
                     /protein_id="NP_001423876.1"
                     /db_xref="GeneID:289230"
                     /db_xref="RGD:1310261"
                     /translation="MMLNSDTMELDLPPTHSETESGFSDCGGGPGPDGAGSGDPGVGQ
                     VRSLELGESGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLL
                     PTLPPDKKLSKIEILRLAICYISYLNHVLDV"
     misc_feature    766..981
                     /gene="Nhlh1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     helix-loop-helix protein 1 (HEN-1) and similar proteins;
                     Region: bHLH_TS_HEN1; cd19701"
                     /db_xref="CDD:381544"
     misc_feature    766..981
                     /gene="Nhlh1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     helix-loop-helix protein 1 (HEN-1) and similar proteins;
                     Region: bHLH_TS_HEN1; cd19701"
                     /db_xref="CDD:381544"
     misc_feature    order(814..816,826..828,832..840,844..846,859..861,
                     913..924)
                     /gene="Nhlh1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(814..816,826..828,832..840,844..846,859..861,
                     913..924)
                     /gene="Nhlh1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(853..858,865..870,874..879,925..927,934..936,
                     946..948,952..957,967..969,973..978)
                     /gene="Nhlh1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(853..858,865..870,874..879,925..927,934..936,
                     946..948,952..957,967..969,973..978)
                     /gene="Nhlh1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381544"
ORIGIN      
        1 aggtgtgtga atgtgcggtg agtgtgtgaa tgtgtgggtg tgtgagtgtg tgcatgtacg
       61 tatgagtgtg cgtgtgagtg actccagttc cggattgagg ccatccctcc tgcctaggcc
      121 ttcaggatgt gtacccttct catccgtcct ggatcctgtt cagccacaac aagctgcccc
      181 taagagctct agaaactgct cactaacttt gcagacagat gacccttgag cagcgagaag
      241 agactggggc tctccacgct cgcttgctgt ccccctcact tgtcaccttg gattcctgga
      301 gagtccttct aggctaaact cactgggaaa ggcccagtgg ttatgagacg ggcaaactta
      361 gctgagctcc aagaagctta tgtcttcttc cacaggccat gccacggact atggggctcc
      421 aggctggaat cttgaccatg aaactttgaa gtaactgctt tccagagctc agtggcagac
      481 cctagcactc gaggcccttc ctgcctttct cacaaccctc tttcaagctc ccaaagggag
      541 gggtggggag aggatccgca tttccatagg tgtggatttt ccaccatgat gctcaactcc
      601 gacaccatgg agctggatct tcctcccacg cactcggaga ccgagtcggg ctttagcgac
      661 tgtgggggcg ggccgggccc ggatggtgct ggatcgggcg atccgggagt gggccaggtc
      721 cggagcttag agctcggaga gtccggccgc aaagacctgc agcacttgag ccgtgaggag
      781 cgcaggcgcc ggcgccgcgc cacggccaag taccgcacag cgcacgccac gcgggagcgc
      841 atccgcgtgg aagccttcaa cctggccttc gccgagctgc gcaagctgct gcccactctg
      901 cccccggaca agaaactctc caagattgag atcctgcgcc tggccatctg ctatatctct
      961 tacctgaacc acgtgctgga tgtctgaact cagtccgaat ccggccctgg attctcccct
     1021 tttccctggg cctctccaga gccccttgtc accatgcatt acttagaatg gccggctgct
     1081 gcccatccca gagcaccagg ctcccgtccg tcctgaaggc cactttcttt tctttggccc
     1141 aggaatgtga aggatgttct taagggttcc ttcagagagt tgttcgggcc tagctggtca
     1201 gggttgcttg tcagagtggt cagaatggag tccttgctgg gttaactaag cctagcctct
     1261 actcagctgc tgccttttct gccccatgtc caagttttca gagaccccag accctgactc
     1321 tgtcttctga caatggtggg actcagcaga ataggaaggg gaactgacta gtagcagagg
     1381 ttgggcaaac ggggttccta actcccagac ttgtctgtcc atgcgggggt gggggaggga
     1441 gggcatggac tcttgggaag gcagagagat gagggaggtg actcctgggt agccagggat
     1501 tataggaaaa ttcttccctt tgtctctctt gctcctgagg cttaggatat atagacctca
     1561 gatctaactt ggtagtgagt gccttgcctt cctggagctg actggccact ccccgggtcc
     1621 cttcccacac ctgccatccc agaattctcc ctttccctgt gctgtctaga gaaaggaaca
     1681 cctcagccct gggataagga ggacacctcc aaacagccca gggcaccttg cagaaggctc
     1741 aggccctgag tggggcagct cttcagccgc tgcttctgtc ccagtggacc cttgaaaaca
     1801 tgcgaacccc accagctcct ccctcagacg caggaggatg cctgcgactg ccctctgcga
     1861 aggatctagg gccttattac atttccccct tccattctta aattgccgtg ggcaggaagg
     1921 tgcccctccc cccccatgct gctgagccta ccagcccttg tagcctgtga cctcggtctc
     1981 tgggctttag actccctgta gatgaagtca ctgcttttct ctgctccgtc cactctcaca
     2041 ccaaactcct agctctacaa ggatatttat ttatgtattt atttattcac ttatttattt
     2101 atttatttat aaatattact atttattacc gagttatgca ctttggggta gggcgaggag
     2161 ggctccttgc agcgagctct agctagggtc ctcttgcttt ctcccgggtc acttcttcct
     2221 tctccagtgc aagcgtgggg gtggggatcc cttcacccac catactggta cgccttcctc
     2281 agctccatct gtctctgtcc cctttcctct ggaatagtgc cccttcccag cctcccagct
     2341 tccgggggtc tctctcaatc tctgcccccc aatcctgaca atcccacttc agtcctatct
     2401 actccattcc tctttaccag ccctgctttt tccaatatca ctaggagcag accccgggct
     2461 ctgtgtctag tgtcctgtgt ggaagtcttt gtctggttgc attcctactt tcttacaaaa
     2521 agaaaaatta aagtgacctc gatctagtac ca
//
LOCUS       NM_001107226            4551 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus SH3 domain and tetratricopeptide repeats 1
            (Sh3tc1), mRNA.
ACCESSION   NM_001107226 XM_001057749 XM_001057812 XM_006251125 XM_223527
VERSION     NM_001107226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4551)
  AUTHORS   Senderek,J., Bergmann,C., Stendel,C., Kirfel,J., Verpoorten,N., De
            Jonghe,P., Timmerman,V., Chrast,R., Verheijen,M.H., Lemke,G.,
            Battaloglu,E., Parman,Y., Erdem,S., Tan,E., Topaloglu,H., Hahn,A.,
            Muller-Felber,W., Rizzuto,N., Fabrizi,G.M., Stuhrmann,M.,
            Rudnik-Schoneborn,S., Zuchner,S., Michael Schroder,J., Buchheim,E.,
            Straub,V., Klepper,J., Huehne,K., Rautenstrauss,B., Buttner,R.,
            Nelis,E. and Zerres,K.
  TITLE     Mutations in a gene encoding a novel SH3/TPR domain protein cause
            autosomal recessive Charcot-Marie-Tooth type 4C neuropathy
  JOURNAL   Am J Hum Genet 73 (5), 1106-1119 (2003)
   PUBMED   14574644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 24, 2025 this sequence version replaced
            XM_006251125.5, NM_001107226.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.17197.1,
                                           SRR26643287.30542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               JAXUCZ010000014.1  79241359-79241687
            330-557             JAXUCZ010000014.1  79245678-79245905
            558-632             JAXUCZ010000014.1  79247962-79248036
            633-760             JAXUCZ010000014.1  79250383-79250510
            761-866             JAXUCZ010000014.1  79250842-79250947
            867-1013            JAXUCZ010000014.1  79252155-79252301
            1014-1224           JAXUCZ010000014.1  79252901-79253111
            1225-1301           JAXUCZ010000014.1  79254113-79254189
            1302-1497           JAXUCZ010000014.1  79254965-79255160
            1498-1631           JAXUCZ010000014.1  79258759-79258892
            1632-1673           JAXUCZ010000014.1  79260358-79260399
            1674-3353           JAXUCZ010000014.1  79263174-79264853
            3354-3534           JAXUCZ010000014.1  79268013-79268193
            3535-3685           JAXUCZ010000014.1  79269560-79269710
            3686-3808           JAXUCZ010000014.1  79270972-79271094
            3809-3959           JAXUCZ010000014.1  79271275-79271425
            3960-4156           JAXUCZ010000014.1  79272325-79272521
            4157-4551           JAXUCZ010000014.1  79274229-79274623
FEATURES             Location/Qualifiers
     source          1..4551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4551
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats 1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
     exon            1..329
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..557
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    371..373
                     /gene="Sh3tc1"
                     /note="upstream in-frame stop codon"
     CDS             377..4414
                     /gene="Sh3tc1"
                     /note="SH3 domain and tetratricopeptide repeats-containing
                     protein 1"
                     /codon_start=1
                     /product="SH3 domain and tetratricopeptide
                     repeat-containing protein 1"
                     /protein_id="NP_001100696.1"
                     /db_xref="GeneID:305441"
                     /db_xref="RGD:1305610"
                     /translation="MRSFREEEATSEDLSTMGQGPEEPPGGCSLEDKIQSISMGLPTS
                     QERTGPEEAEATTVRGDVAPPCGMVGQAAEPPSNQMAVYPTDLTLQLLAVRRKSGLRS
                     PSLQQTLRSRLRLLENDSREVARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTY
                     HALGFTHHCLENLLVDQTFWLLSPSEEEETAILIYVNKDALKQTHKSLLAQEGSFFVL
                     CPDHCVRRTKEPQGAGKGPQTLRRASGVTLGVPVVETVSSSPTPSMSSKAEAVEAEPE
                     PLTPFHQWTLRVPWDPIDESMSGPGTPDAQFMRFGLASAIADFQGSGPEEMSFSVGDV
                     IEIVGAQVPGLPWCLGQHMASGQVGFVRTGLVRMQGPASDLESSIFLSEEERSFFRSE
                     AHFSDEDARRLLCRTSGTDVCTTCSLDWLEEAEGEQLEQQEMSLPHLNPEPHESLHMV
                     KNVLEKCKACPDHPEDPVSWSLGAVSSRVSSPDLEEPPFCLDPDDDWTDPEPPDSLLQ
                     VLSAPGYRAQFRSLYDISLPCLSTALYSFDDEEELAERLAQARGVAKKVDLGMALARL
                     CLLLGRLCARKLKLSQARVYFEEALGALEGSFGDLSLVAAVYSSLATVYLKQKNGEKC
                     VQLAPKAAALLLGTPGHSCSTDAELLKYALRRVVCGLSPQAEARACFLLARHYTHLKQ
                     PEEALPYLERLLRLNRDVGTPQASWPEDCYLLLADIYGRKCLPHLALSCLKVSSLWTR
                     CSLAGSLRSVDLVLQNAPGPNSQRSTGHSLPSQIAHYLRQALASLPPGTGQTLRGPLY
                     ASLAQLYSYHQQYGQAIAFMSQAAEADTAAGVHPVVDRLVALAWLHLLCGKSLVAMDI
                     LKCVSDAAVANKDQECVMMNMVAMALKRMGRTRQAAEGYFRALHMAYSQGHLQSQAVV
                     LANFGALCLQAGARSLAQHYLREAVGLFSQLPSGVCGRDFTQVLLWLGQLCTRRTLPQ
                     QAKCYYEWAFLVAVETDHLESQLQAVQKLCHFYSKVMPNEVRCVIYHEFQLALARKTA
                     DKVLEGQLLEAISQLYLSLGTERAYKSALDYTKRSLGIFIDLQQKEKEARAWLQAGKI
                     YYILRQNELVDLYIQVAQNAALYTGDPKLGLELFEAAGDIFFNGTWEREKAVSFYRDR
                     ALPLAVTVGDQEVELRLCNKLVALLSALEAPQEGLEFAHEALALSITLGDRLNERVAY
                     HRLATLHHRLGHGELAEHFFLKALSLCTSPLEFDEETLYYVKVYLVLGDIIFYELKDP
                     FDAAGYYQLALAAAVDLGHKKAQLKIYTRLATIYHNFLMDREMSLFFYQKARTFASEL
                     NLRRTNLVPQHFCSRAPWLAPGYPS"
     misc_feature    1310..1474
                     /gene="Sh3tc1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    1310..1474
                     /gene="Sh3tc1"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(1325..1327,1331..1333,1340..1342,1352..1354,
                     1412..1417,1460..1462,1466..1471)
                     /gene="Sh3tc1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212818"
     misc_feature    order(1325..1327,1331..1333,1340..1342,1352..1354,
                     1412..1417,1460..1462,1466..1471)
                     /gene="Sh3tc1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212818"
     misc_feature    2189..2341
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2189..2341
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(2192..2194,2201..2206,2213..2218,2222..2224,
                     2378..2380,2387..2392,2399..2404,2408..2413,2504..2506,
                     2513..2518,2525..2530,2537..2539)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(2192..2194,2201..2206,2213..2218,2222..2224,
                     2378..2380,2387..2392,2399..2404,2408..2413,2504..2506,
                     2513..2518,2525..2530,2537..2539)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    <2372..3076
                     /gene="Sh3tc1"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    <2372..3076
                     /gene="Sh3tc1"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    2372..2464
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2372..2464
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2477..2575
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    2477..2575
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    <2699..4066
                     /gene="Sh3tc1"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3899"
                     /db_xref="CDD:443106"
     misc_feature    <2699..4066
                     /gene="Sh3tc1"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3899"
                     /db_xref="CDD:443106"
     misc_feature    order(3860..3862,3869..3874,3881..3886,3890..3892,
                     3962..3964,3989..3994,4001..4006,4010..4015,4112..4114,
                     4121..4126,4136..4141,4148..4150)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(3860..3862,3869..3874,3881..3886,3890..3892,
                     3962..3964,3989..3994,4001..4006,4010..4015,4112..4114,
                     4121..4126,4136..4141,4148..4150)
                     /gene="Sh3tc1"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    3860..3943
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3860..3943
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3869..4075
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3869..4075
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3956..4066
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3956..4066
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    3983..4204
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    3983..4204
                     /gene="Sh3tc1"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:315987"
     misc_feature    4109..4198
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    4109..4198
                     /gene="Sh3tc1"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            558..632
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..760
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..866
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1013
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1224
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1301
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1497
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1631
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1673
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..3353
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3534
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3685
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3808
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3959
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4156
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4551
                     /gene="Sh3tc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accacagagc acggggctgg cagtaggcag gcagggacag ggcctggctc tggtccacaa
       61 ggagctaatg atcaactggc cactgaaatc cttgccacag caccctagcc tgtcttaggt
      121 ctccaggccc ctaggctcag ggaggaagtg gggcaggaag cagggggcgg tggcagtact
      181 gagcagtcag ccggctgtgg gcggactctg cctgtccagg ccagctggag acagcctgta
      241 ggccagtcag caaggagccg agtctgtagt ggccacctgg cacctgcatt cctgagcctg
      301 gaaggaagtt tactgaagga cagatgctga aggccagcaa catgcccagc tcttggcctt
      361 gaggccactg tgagtcatga ggagcttcag ggaggaggag gcgacttctg aggatctgtc
      421 caccatgggg cagggccctg aggagcctcc aggaggctgt agcctggaag acaagatcca
      481 gagtatatcc atgggcttac ctactagtca ggagagaaca gggcctgagg aggctgaggc
      541 aacaacagtc agaggtgacg ttgctcctcc ctgtggcatg gttgggcaag ctgctgaacc
      601 cccttccaat caaatggcag tgtatccgac agacctcacc ctgcaattgt tggctgtgag
      661 gcggaagagt ggactgcgga gccccagcct acagcagacc ctgagaagcc gactccgcct
      721 gctggagaat gacagccggg aagtggcccg agtacttgga gaactgtcag ccaggctgct
      781 gtccatccac agtgaccagg accggatcgt ggtgacgttt aagacttttg aagaaatctg
      841 gaagttttcc acctatcatg ctcttggctt cacacatcac tgcctggaga acctgctggt
      901 ggaccagacc ttctggctgc tttcccccag tgaggaggag gagactgcca tcctcatata
      961 tgtaaacaag gatgccttga agcagacaca caagagcctt ctcgcacaag aagggtcctt
     1021 cttcgttctg tgtcccgacc actgtgtgag gaggacaaag gaaccccaag gtgcagggaa
     1081 gggcccccag accctcagac gggcttccgg ggtcactctg ggagtaccag ttgtggaaac
     1141 agtctcctca tcccccacac ccagcatgtc ctccaaagca gaagcagtag aggctgagcc
     1201 agagcccttg actccatttc accagtggac tctcagggtc ccatgggatc ccatcgatga
     1261 atccatgagt ggacctggga cgcctgatgc ccagttcatg aggtttggcc tggcctctgc
     1321 aatagctgac ttccagggct caggcccgga agagatgtcc ttcagcgttg gtgatgtcat
     1381 cgagatcgtc ggtgcccagg tgcctggcct gccctggtgt ttgggccagc acatggcctc
     1441 tggccaggtg ggctttgtga ggactggcct tgtccgcatg cagggcccgg catctgacct
     1501 ggaaagttca attttcctca gcgaggaaga aaggtcattc ttcagaagtg aggctcactt
     1561 ctcagacgag gatgcccggc ggctcctgtg caggacatct ggcacagatg tgtgtaccac
     1621 atgcagcctg gactggttag aagaagctga gggagaacag ctggagcaac aagaaatgtc
     1681 tctgcctcac ctgaacccag agccacatga gagtctgcac atggtaaaga acgttttaga
     1741 gaagtgcaag gcctgccctg accaccctga agaccctgta tcctggagcc ttggagcggt
     1801 gtccagcaga gtgagttcac cggaccttga ggagcccccc ttctgcctgg atcctgacga
     1861 tgactggaca gaccctgagc ctccggactc actgctgcag gtcctgagtg cccctggtta
     1921 tagggcccag ttccggagcc tgtatgatat ctcacttccc tgcctgagca ccgcactcta
     1981 tagctttgat gatgaagaag agttggctga acgcttggca caggcccgag gagttgccaa
     2041 gaaagtcgat ttgggcatgg ccctggcaag gctctgcctc ctgctggggc ggctgtgtgc
     2101 ccgaaagctc aaactatccc aggcccgggt gtactttgaa gaggccctgg gggctctgga
     2161 gggaagtttt ggggacctct ccctggtggc ggccgtgtat agcagcttgg ctactgtgta
     2221 cctgaagcag aagaacgggg agaagtgtgt gcagctggca cccaaagccg cagcgctgct
     2281 cctgggaacg cccggccact cctgcagcac agatgccgag ctcctgaagt acgcactgcg
     2341 cagggtcgtc tgtggcctca gcccacaggc cgaggcccgg gcctgcttcc tgctggcccg
     2401 gcactacacc cacctcaaac agcctgagga ggcactgcca tacttggaga gactgcttcg
     2461 cctcaacagg gatgtgggga ccccgcaggc ctcgtggcct gaagactgtt acctgcttct
     2521 ggcggacatc tatggccgga agtgcctgcc gcacctggca ttgagctgcc tcaaggtgtc
     2581 ctcactgtgg acaagatgct ctctggctgg ctccttgagg agtgtggacc tggtactcca
     2641 gaatgctcct gggccaaaca gccaaaggag cacaggtcat agccttccct cccagattgc
     2701 tcactacctc agacaggcat tggcctctct gcctcccggc acgggacaga cactgcgagg
     2761 gccactctat gccagcctgg ctcaattgta cagttaccac cagcagtacg gccaggccat
     2821 agccttcatg tctcaggctg cagaagctga cactgcagct ggggtccacc ctgtcgtgga
     2881 ccgcttggtg gcgctcgcct ggctgcacct gctttgtggg aaaagcttag tagccatgga
     2941 catcctgaag tgcgtctcag acgcggccgt ggccaataag gaccaggaat gtgttatgat
     3001 gaacatggtg gccatggccc tgaagaggat gggcaggacc cggcaggctg ctgaaggcta
     3061 cttccgagct ctgcacatgg cctacagcca gggccacctg cagagccagg cagtggtcct
     3121 agctaacttt ggggccctgt gcctgcaagc tggcgcacgc agcttggccc agcactacct
     3181 gcgggaggcc gtggggctct tctcccagct gcccagtggc gtgtgtggcc gtgacttcac
     3241 ccaggtgctc ctgtggttgg gccaactgtg tacgcgccgg accctccccc agcaggccaa
     3301 gtgctactat gagtgggcct ttctggtggc tgtggagacg gaccatctgg agagtcagtt
     3361 acaggcggtg caaaagctgt gccacttcta cagtaaggtc atgcccaacg aggtgcgatg
     3421 tgtcatctac catgagttcc aactggctct ggcacgcaag accgctgaca aggtgctgga
     3481 ggggcagctc ctggaggcca tcagtcagct ctacctgtcg ctgggcactg agcgggccta
     3541 caagtcggct ctggattaca ctaaacggag cctggggatt ttcatcgacc tgcagcagaa
     3601 ggagaaggag gcacgcgcct ggctgcaggc agggaagatc tactatatcc tccgtcagaa
     3661 tgagctggtg gacttgtaca tccaggtggc acagaatgca gccctgtata ccggggaccc
     3721 taagctgggg ctggaactgt ttgaggcagc tggggacatc ttcttcaatg ggacctggga
     3781 gcgggagaaa gctgtgtcct tctaccggga ccgggcactg cccctggctg tgactgtagg
     3841 agaccaagaa gtggagctgc gcctgtgcaa caagctggtg gccctgctgt ctgcactgga
     3901 ggcaccccag gagggcctag agttcgccca tgaggcccta gcactcagca tcaccctagg
     3961 tgaccggctg aatgagcgag tggcctacca caggctagcc accctgcacc accggctggg
     4021 ccacggggaa ctggccgagc acttcttcct gaaggctctg tcgctctgca cctcgcccct
     4081 ggaatttgat gaggagaccc tgtactatgt gaaggtctac ctggtactgg gtgacatcat
     4141 cttctatgag ctgaaggacc ccttcgatgc agctgggtat taccagctgg ctctggcagc
     4201 agccgtggac ctgggccaca agaaggctca gttgaagatc tatacacgcc tggctaccat
     4261 ctaccacaac ttcctcatgg accgagaaat gtccctcttc ttctaccaaa aagcaaggac
     4321 ctttgcctca gaactgaatc tccgcaggac caacctggta ccccagcact tctgtagccg
     4381 ggcaccctgg ttggcccctg gctacccatc ctgacaacct gagaaggggc acgtacaacg
     4441 ggactcttcc tcttcttggg gtatgggcaa cctattgtta ttattattat tcttttgctg
     4501 agggttgggg gtaactgaag gaccaaacag tagtaaatat ttttcagcaa c
//
LOCUS       NM_001437239            4374 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus myogenesis regulating glycosidase (Myorg),
            transcript variant 1, mRNA.
ACCESSION   NM_001437239 XM_063288108
VERSION     NM_001437239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4374)
  AUTHORS   Datta,K., Guan,T. and Gerace,L.
  TITLE     NET37, a nuclear envelope transmembrane protein with glycosidase
            homology, is involved in myoblast differentiation
  JOURNAL   J Biol Chem 284 (43), 29666-29676 (2009)
   PUBMED   19706595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063288108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26986.1,
                                           SRR26643289.14997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000005.1  61460228-61460304   c
            78-4374             JAXUCZ010000005.1  61452956-61457252   c
FEATURES             Location/Qualifiers
     source          1..4374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4374
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="myogenesis regulating glycosidase"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
     exon            1..77
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     exon            78..4374
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    316..318
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="upstream in-frame stop codon"
     CDS             325..2475
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /codon_start=1
                     /product="myogenesis-regulating glycosidase"
                     /protein_id="NP_001424168.1"
                     /db_xref="GeneID:366360"
                     /db_xref="RGD:1309821"
                     /translation="MPQNLQEKSQVYPRHRLGSHAGPKSLEVIPGATMYTFLPDNFSP
                     AKPKPTKELRPLLCSVVLGLLLVLAAVVAWCYYSASLRKAERLRAELLDLNRGGFSIR
                     NQKGEQVFRLAFRSGALDLDSCSRDGALLGCSRTADGRPLHFFIQTVRPKDTVMCYRV
                     RWEEAAPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDA
                     AFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSMRLQARYHHTSYKPPAGRTAAP
                     ELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPASEAFRDPIWSTWALYGRSVDQNKVLQ
                     FAQQIRQHRFNSSHLEIDDMYTPAYGDFDFDESKFPNATDLFHRLRDAGFRVTLWVHP
                     FVNYNSSRFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTRPEAREWFQGHLRRL
                     RSRYNVASFKFDAGEVSYLPPDFSTYKPLSDPSVWSRRYTEMALPFFSLAEVRVGYQS
                     QNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMIGGNAVPERTAGRP
                     DGPGPERELYVRWLEVAAFMPAMQFSIPPWQYDAEVVAIAHKFAALRASLVAPLLLEL
                     AGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAG
                     KWRSYKGELFDKTPVLLTDYPVDLDEVAYFTWAS"
     misc_feature    1261..2376
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    1261..2376
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="glucosidase NET37; Region: GH31_NET37; cd06592"
                     /db_xref="CDD:269878"
     misc_feature    order(1378..1383,1702..1704,1708..1713,1825..1827,
                     1879..1881,2131..2133,2137..2139)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
     misc_feature    order(1378..1383,1702..1704,1708..1713,1825..1827,
                     1879..1881,2131..2133,2137..2139)
                     /gene="Myorg"
                     /gene_synonym="RGD1309821"
                     /note="putative active site [active]"
                     /db_xref="CDD:269878"
ORIGIN      
        1 ggctgatcaa ctcctgctag cgtggagaga ggatcagctg gaggaccctt cttcccttct
       61 ttgtggcggt cactgagagt tctcaccgat ttggcaagcc gtggggcctg agagaaacaa
      121 gggtaagaca ccagctgtcc tggacaagag tcctgccttt gacatttgtc aagctctcag
      181 ctcctctact aggctgcaga aatggaaata ctgtgaaaca acaacaacaa caaaatcagt
      241 ttcttctctc acccctttgc agacatcagc acgacagttt cagatgggcc ctggtgtggt
      301 ggttcctttc ttagctagga actgatgccc cagaaccttc aggagaagag ccaggtctac
      361 cccagacatc gacttggtag ccacgcaggc cctaaaagtc tcgaagttat cccaggagca
      421 accatgtaca ctttcctgcc tgacaatttt tcacctgcca aacccaagcc cactaaagag
      481 ctgaggcctc tgctatgctc cgtggtactg ggactgctgc tggtgctggc cgcagttgtg
      541 gcctggtgct actatagcgc ctccttacgc aaagctgaac gcctgcgcgc agagctgctg
      601 gacctgaacc gtggcggctt ctccatccgt aaccagaagg gtgagcaagt cttccgcttg
      661 gccttccgtt cgggtgcgct ggatcttgac tcctgtagcc gggacggtgc cctgcttggc
      721 tgctcccgaa cggccgatgg gcgcccgttg cacttcttta tccagactgt acgacccaag
      781 gacactgtaa tgtgctaccg cgtgcgctgg gaggaagctg caccagggcg tgctgtagag
      841 cacgcgatgt ttctgggaga tgctgcagcg cactggtatg gtggcgcaga gatgaggacg
      901 caacactggc ccatccgcct agatggccag caagagccgc agccatttgt cacgagcgac
      961 gtctactctt ctgacgccgc attcgggggc atccttgagc gctactggct atcttcccgc
     1021 gcggccgcca tcaaagtcaa tgattcagtg cccttccacc tgggctggaa cagcaccgag
     1081 cgttcgatga gattgcaggc acgctaccac cacacatctt acaagccacc agccggccgg
     1141 actgcagcgc cagagctcag ctaccgcgtg tgcgtgggct cagatgtcac ctccatccac
     1201 aagtacatgg ttcgacgtta cttcaacaaa ccgtccaggg taccagcgtc agaggccttc
     1261 cgagacccca tttggtccac gtgggctcta tatgggcgct ctgtggacca gaacaaggtg
     1321 ctgcaattcg cccagcagat ccgccagcac cgcttcaaca gcagccatct ggaaatcgat
     1381 gacatgtaca cgccggccta tggtgacttt gatttcgacg agagcaagtt ccccaacgcc
     1441 actgacctgt tccaccgcct gcgagatgct ggcttccgcg tcacactttg ggtgcatccg
     1501 tttgtcaact ataactcgtc gcgtttcggc gaaggtgtgg agcgcgagct gttcgtgcgg
     1561 gagcccacgg gccgcctgcc cgcgctcgtg cgctggtgga acggcattgg cgcggtgctg
     1621 gacttcacgc gcccagaggc ccgagagtgg ttccagggac acctacggcg cctgcgctcg
     1681 cgctacaacg tggcctcctt taagttcgac gcgggtgaag tcagctacct gcccccggac
     1741 ttcagcacct acaagcctct gtctgacccc agtgtgtgga gcaggcggta caccgagatg
     1801 gcgctgccct tcttctcgct agccgaagtc cgcgtggggt accagtcaca gaacatctcc
     1861 tgcttcttcc gtctagtgga ccgcgactcg gtatggggct acgacctggg gctgcgctct
     1921 ctcatccctg cggtgctcac cgtcagtatg ctgggctatc cgttcatctt acctgatatg
     1981 ataggtggca acgcggtgcc ggagcgcaca gcgggccgcc cagatgggcc ggggccagag
     2041 cgcgaactct acgtgcgctg gctggaggtg gccgccttca tgcctgccat gcagttttca
     2101 atccctcctt ggcagtatga cgcagaagtg gtagccatcg cacataaatt cgctgctctg
     2161 cgcgcctccc tcgtggcgcc actgctgctg gagcttgctg gtgaggtcac cgacacgggc
     2221 gaccccatcg tgcgccccct gtggtggatc gcacccgggg atgaaacggc tcaccgcatt
     2281 gactcacagt tcctcatcgg ggacacgctg ttggtggcac cggtactgga acctggtaag
     2341 caagagcgcg atgtctacct gcctgccggc aaatggcgaa gttacaaggg tgagcttttt
     2401 gacaagacgc ctgtgctgct cacggattac cctgtcgacc tggatgaggt cgcctatttc
     2461 acctgggctt cctgacccag ctcagaacct aggaatccca cagccctaac cccagccttc
     2521 atacaaactt ttaatcctct accacgcgcg aacggtgaac cctcaggaag accccacctc
     2581 tataccatct aggaagtggg caccgacttt aaagtgctcc agccaacagc tgtagatgag
     2641 acctgggagg ggaggtattg aaacaacccc tgcaccagcg cacaatccta agagtcccgg
     2701 ttccttgacc attcgctcca gtctgcagaa agcctctccc ttgggttgga gggcagagaa
     2761 ctgagaggac aaagatctgt tctttgtgtt acacagggtc tggttttaaa agcacagaaa
     2821 gaaacctctc ctcccaccct ggtctttgta gccatccttg tcctctgaaa tgaggaacca
     2881 atcctcttta aaagttccca aatagttttc tgccatattt agaaagtgta cctttaacct
     2941 ggtgttggtg ggatatgcct ttaataccag cactcaggaa gcagagagac aggtggatct
     3001 ccgagatcaa ggccagcatg gtctacagat cgagttccag gaagccagcg ctacgcagag
     3061 aaactctatc tccaaaaaac tgaaggaagg aaggaaagaa gaaaggaagg aaggaagaaa
     3121 ggaaggaaga agagaaagtc taccttcttg atgacagcag ctaagccatg agctcccagc
     3181 acacacctga acagtgactg acctgctctc actcgatctg gggaagaaag atacacagat
     3241 gtttggtttg gccagctgac caggaagcaa aaggcctctt cccagtccat aggagaattg
     3301 aactgaacta atgttctctg tctgtgagaa agactcctaa catgcgttaa catatttgta
     3361 tgtattcata cccagacctg ggccagatgt gcctagtaga tagacttgca gggtcatgca
     3421 ggccggactc gttgccttaa ttcaagaacc tgtgtctatg tgtatgtaca catacttctg
     3481 tcagggcagt ggggagggag agagggagag aggcgcccac catgggtctc tgaaatattc
     3541 ctgaggctag ataagcctag agggaggata cggaggcagc ctcagggctt tgattatgat
     3601 ctaagcccca ttttaggtag actccctagg atactgccaa acccagttta agagtttaaa
     3661 actggagaac tgggctgagg aactgactca gaagacaagc ctgactacct gagttcagcc
     3721 taactcctgc tgtaaaagga gagaacggac aatagggtaa gccctttaag attacccagc
     3781 tgcctccctg cacacacgct ctgagtgtag cccgaacggg aaaaccatgt tctatgctgg
     3841 cagagatgtg cttggcacac gaatgacatt acacgctgat aacctgccag cacacgtatg
     3901 gggaagggct ttcatctcag taattctctt gttctaagaa gatcaactcc agctaccgtg
     3961 aggtgagttt ttcctgattt gccagagaag gtggggaatg aagtggggct cagcttccct
     4021 ctcagagcct gtgcccgaat cattcgtttt ctctgggtga aaggtcctgg tgagagcttc
     4081 agggctcccc agacgcccat ctccatgcca attcttttgt ttcttttcct tggcaatgct
     4141 gaagctagaa cccagggccc caagcatact aagtaagcat tcttcctcag ctctatcctc
     4201 ggtcttcagc cagccgggtg accttgaata agctgctgcc taccccactg agcctcagtg
     4261 ttttctgtgt aagggtgatg taatgcctac ctctaaggtc actttaataa taagcacaga
     4321 catatggaaa gtgcctgaca ccaagtaggt gctcaataaa agatagctat tgta
//
LOCUS       NM_001437341            4754 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus centrosomal protein 120 (Cep120), transcript
            variant 2, mRNA.
ACCESSION   NM_001437341 XM_063277302
VERSION     NM_001437341.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4754)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 4754)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   5  (bases 1 to 4754)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063277302.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1763008.1,
                                           SRR26643298.74070.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000018.1  49387941-49388277   c
            338-494             JAXUCZ010000018.1  49383840-49383996   c
            495-609             JAXUCZ010000018.1  49382222-49382336   c
            610-751             JAXUCZ010000018.1  49379306-49379447   c
            752-900             JAXUCZ010000018.1  49375066-49375214   c
            901-1098            JAXUCZ010000018.1  49373255-49373452   c
            1099-1326           JAXUCZ010000018.1  49370600-49370827   c
            1327-1543           JAXUCZ010000018.1  49369293-49369509   c
            1544-1721           JAXUCZ010000018.1  49367897-49368074   c
            1722-1871           JAXUCZ010000018.1  49365316-49365465   c
            1872-2054           JAXUCZ010000018.1  49364545-49364727   c
            2055-2151           JAXUCZ010000018.1  49361228-49361324   c
            2152-2310           JAXUCZ010000018.1  49360986-49361144   c
            2311-2400           JAXUCZ010000018.1  49358919-49359008   c
            2401-2493           JAXUCZ010000018.1  49354506-49354598   c
            2494-2655           JAXUCZ010000018.1  49352257-49352418   c
            2656-2778           JAXUCZ010000018.1  49348629-49348751   c
            2779-2877           JAXUCZ010000018.1  49344147-49344245   c
            2878-3023           JAXUCZ010000018.1  49331773-49331918   c
            3024-4754           JAXUCZ010000018.1  49326271-49328001   c
FEATURES             Location/Qualifiers
     source          1..4754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..4754
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
     exon            1..337
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="upstream in-frame stop codon"
     CDS             289..3258
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="isoform 1 is encoded by transcript variant 2;
                     centrosomal protein 120kDa; coiled-coil domain containing
                     100; centrosomal protein of 120 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 1"
                     /protein_id="NP_001424270.1"
                     /db_xref="GeneID:307302"
                     /db_xref="RGD:1565619"
                     /translation="MVPKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPV
                     DHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTA
                     QETKQAPKWYQLLSNKYTKFKSEVQISITLETDTKAQVDSFKAKGAPPRDGKVPASLL
                     GVDPKDIVAVLNEEGGYHQIGPAECCTDSFTLSVTIAFATQLEQLIPCTMKLPERQPE
                     FFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEVLRVYLALHSKLQIHLCCG
                     DQSLGSTEIPLSGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPVELAPTVGV
                     SVALQREGIGSQSLIELKTQNGHEPEHSQKRVLTPIKEKTLTGPKSPRVSPAPPQNQT
                     PPTKDDATESEVESLQYDKEPKQVVKGTGSIPASLAQPEATGNPSEVVTSGQKIAVPA
                     TSHHFCFSIDLRSIHGLEISFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQ
                     SYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFL
                     GANGEQCWRQTYSEKVPVIAAQGSNNRIVDLSYTMTLEDYGLVKMREIFVSESSQGMS
                     AVGQRASPPPPPPAPCPSEIQVEPRETLEYKAALELEMWKEMQEDIFESQLKQKELAH
                     MQALAEEWKKRDRERESLVKKKVAEYSILEGKLQQALTELESREQQLVTAETELQRER
                     KELQLERERNLQELQDSVRRARDDCVHQVELERLKLKQLEEDKHRLQQQLNDAENKYK
                     ILEKDFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALK
                     ELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTEQQELLDIRNELNRLR
                     QQEQKQYQDYKEIASGKQGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIIS
                     ELDRQIREVLTKNSASN"
     misc_feature    313..630
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    313..630
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    640..1308
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    640..1308
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Cep120 protein; Region: DUF3668; pfam12416"
                     /db_xref="CDD:463569"
     misc_feature    <2245..>3249
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <2245..>3249
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     exon            338..494
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            495..609
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            610..751
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            752..900
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1098
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1326
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1543
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1721
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1871
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2054
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2151
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2310
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2400
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2493
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2655
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2778
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2877
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3023
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..4754
                     /gene="Cep120"
                     /gene_synonym="Ccdc100; RGD1565619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgccct ttgtcctcca acctcccccg ggctctcggc ccgcgggcct ggttgctagg
       61 cggaagcggg gcgcggcggc gtccgctgcg gctgcccggg cgtttgaata gcggcttagc
      121 aggcggcaaa aggtgccggg gcggcgggct tgttggggag cagggccagg cagcggagca
      181 gccttcatcg agtcggggct gggttagggc ctgggcggcg gcctggggag cggggccggc
      241 ctgcgcccct cactcggcct ctttcctgca gaccccgccg ccacgaccat ggtccccaag
      301 tccgaccagc tgctcatcgt cgtatccatc ctcgaaggtc gccatttccc caaacgtcca
      361 aagcatatgc ttgtggtgga agcaaagttt gatggggagc agttggccac tgatcctgtc
      421 gaccatactg accagccaga atttgctact gagttagcct gggagatcga caggaaagtc
      481 cttcatcagc acaggttaca gcgcactccc atcaaactgc agtgctttgc cttggatcct
      541 cagacttctg ccaaggaaac cgtaggctac attgttttgg atttaagaac agctcaagaa
      601 acaaagcagg cacccaaatg gtaccagttg ctgagtaaca aatacaccaa attcaagtcc
      661 gaggtacaga taagcatcac tttggaaaca gatacaaagg cacaggtgga tagttttaaa
      721 gcaaaaggag ccccacctcg ggatggaaaa gttcctgcta gcctgttagg agttgaccct
      781 aaggacatcg tggcagtgtt gaatgaggag ggaggctacc atcagattgg accagcagag
      841 tgttgtactg actcctttac tctctcagtg accatagcat ttgccaccca gttggaacag
      901 ttaattccat gtaccatgaa gcttccagaa aggcagcctg agtttttctt ttactattct
      961 ttattgggaa atgatgttac aaatgagccg tttagtgatt tgatcaaccc gaactttgag
     1021 ccggagaggg cgtctgtccg catacgaagc agcgtggagg tccttcgtgt gtacctggct
     1081 cttcactcga aactgcagat ccatctctgc tgtggagacc agtcactcgg cagtacagaa
     1141 atacctctaa gtggattact gaagaagggc agcacagaga ttaaccagca tccagtcaca
     1201 gtcgagggtg cgtttaccct tgaccctcca aaccgagcca agcagaagct cgctcctgtt
     1261 cctgtcgagc tggccccaac tgtgggagtg tcagtggctc tgcagagaga aggcatcggc
     1321 tcccagtctt taattgaatt aaagacccag aatggacatg agcctgagca ctcacagaag
     1381 agagttttaa cccccataaa ggagaagaca ctcactgggc caaaatcacc aagggtgtcc
     1441 cctgccccac ctcaaaacca gacacctcca accaaggacg atgccacaga aagtgaagtg
     1501 gagagcctgc agtacgataa ggagccgaag caggtggtga agggcactgg ttccatacct
     1561 gcttcgctgg cccagccaga ggcgactggc aacccatcag aagtggtgac atcggggcag
     1621 aagattgctg ttccagcaac atcacaccac ttctgctttt caatagactt gagaagcatc
     1681 catggcttgg aaattagttt tccagtcaac tgcatattga ggtactccta cccattcttc
     1741 ggcagtgcag ctcctattat gactaaccct cctgtagaag ttcggaagaa catggaagtt
     1801 tttcttcctc agtcttactg tgcatttgat tttgcaacta tgcctcacca gctacaagac
     1861 accttcctaa ggattccact gcttgtagaa ctatggcaca aggataaaat gagtaaagac
     1921 ttactccttg ggattgcaag aattcagctt tctaacatct tgtcttcaga aaagacccgg
     1981 tttctaggtg ctaatggtga acagtgctgg cgacagactt acagtgagaa agtgcctgtc
     2041 atagcggccc aggggtcaaa taacaggata gtagaccttt cttacacaat gactctggag
     2101 gactatggcc tggtgaaaat gcgtgagatc tttgtatctg agtcatctca gggcatgtct
     2161 gctgtgggtc agagggcgtc tcctcctcct cctcctccag ctccttgccc ttctgagatc
     2221 caggtggagc cccgggagac cttagagtac aaggctgcac tggagctgga gatgtggaaa
     2281 gagatgcagg aggacatatt tgaaagtcag ctgaagcaga aagaactggc tcacatgcaa
     2341 gctcttgcag aagagtggaa aaaaagggac cgggaaagag agtcactagt gaagaaaaag
     2401 gtagctgagt acagtattct agaaggcaaa cttcaacaag ccctaacgga gctcgagagc
     2461 cgagagcagc agcttgtcac tgcagagaca gagcttcaaa gagagagaaa ggaactgcag
     2521 ttagaacgag agcggaacct tcaagagctg caggactctg tccgaagggc cagagacgac
     2581 tgcgtgcacc aagtggagct ggagaggctg aagctgaagc agctggaaga ggacaaacac
     2641 cgccttcagc agcagcttaa tgatgctgaa aataagtata agattttgga aaaagatttt
     2701 cagcagttca aggaccaaca aaacaacaaa ccagaaatac ggctgcagtc agaaataaac
     2761 ctcctcacct tggaaaaggt tgaacttgaa agaaagttgg agtctgcaac caagtctaaa
     2821 ctgcattaca agcagcagtg gggccgagct ttgaaagaac ttgccagact caagcagagg
     2881 gagcaagaaa gccaaatggc tcgccttaaa aaacagcagg aggagttgga gcagatgcgg
     2941 ctgcgttacc tggctgctga ggagaaagac acagtgaaaa ctgagcaaca agaactgctg
     3001 gacataagga acgaactgaa caggttacgg cagcaagaac agaaacagta ccaggactac
     3061 aaagagattg caagtgggaa acagggcagc cctcggggct ctgggctgga agaaggcctg
     3121 gatgactact tgacacgtct gatagaagaa cgggatactt tgatgagaac gggtgtctat
     3181 aaccatgagg accgcataat aagtgaactc gaccggcaga tcagagaggt tttgacaaaa
     3241 aacagtgcca gtaattaaat gcattgagga agtctttaca gctactctag gtctgtgttt
     3301 tgaatttttt gtaaactcct caaaagcaag gaaaacggcg actttagagt gctcttttta
     3361 attttttata agctgaattt tatatattac tgtatatagt atttatttga ttttacttac
     3421 gctacctctc caatgctggt ttcatttgta attgtatttt atatgctcat ttaaaatgac
     3481 ttttcagtgt tcttcagttc aaaatctatt gtttgacttt aaaaacagcc tttcagaact
     3541 tatcccagga gaactggcca cagtagttcc cagctatata agttttttat gttgagtcaa
     3601 gagagtatgt gttgcacttt aaaaatgctg tgccctgttc cctttgattg tagatatctt
     3661 caaattaaag ccaattataa gtgtagccat ttttaaaaaa gcatttatat gaccagtctt
     3721 tttcccttaa cctgtggtat ttgcacatga caactttgaa aataaagcag tcacaggcag
     3781 aaaagctatg tgacatgttg gctgacaaat tagtcattgc ttaaatacag ttcatgtaga
     3841 ttaagtttaa aaacaaattc ggaatttcac tggactccat tttaagaatg tgagaaaaca
     3901 gcttgttctg atcgcagcct cctgctcaca gctgcatgag gctggttgtc gttaaaattg
     3961 taggtcgcct ttgtctctca gtggtggcag tacagcttca gacagactga ggaaacagac
     4021 acctagcgac attagctgag aacaccttcc tccctctgca gtcattctgt tttccaagag
     4081 gcagtgcagc gtgagtcgtg taagccgcag agcttccctc cgtgttctcc agaccacctc
     4141 agcctcatgg cggcactcat ccctatgtct gcacaacaat gaacaggtta gtgagcaaac
     4201 tcccagttca tgtgcgatct taaaacatag aaagtaaaaa ttctgattcc ccaaaataac
     4261 agatgtaagt gtatccttcg gcaagtatga gctaattacc agtcacttca gcataagcaa
     4321 agcgggttac acggtaatct tcactaggtg tgtttctggt ttgtgaaatt aaagcctcca
     4381 taggagtcat atgcttcttt tctttaattt tccgtctttg tcttctaaaa gcaactgagc
     4441 agtaaatcac agaaaggctg ctgggtctga gggtggtgag acagatgatc atagcaggga
     4501 tttgaaatat gaattatggt tacacggtcc tgattttctt ggtgacatga atggagcaaa
     4561 aggatttttg ttttagaagg tcctggccca atgttggttc ttcctcctgt atcctgtgag
     4621 gcctggagct tttcaaacac tagagggggc ctaagagtaa gcagaaggac ttctaaaatg
     4681 tgtgtgtgct ttgccttcaa gaaagccatc tttgagctac tgtaatttga caaataaaat
     4741 cctcactgcg tgca
//
LOCUS       NM_001437571            9080 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus nuclear receptor co-repressor 2 (Ncor2),
            transcript variant 1, mRNA.
ACCESSION   NM_001437571 XM_006249305
VERSION     NM_001437571.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9080)
  AUTHORS   Barbieri,C.E., Bangma,C.H., Bjartell,A., Catto,J.W., Culig,Z.,
            Gronberg,H., Luo,J., Visakorpi,T. and Rubin,M.A.
  TITLE     The mutational landscape of prostate cancer
  JOURNAL   Eur Urol 64 (4), 567-576 (2013)
   PUBMED   23759327
  REMARK    Review article
REFERENCE   2  (bases 1 to 9080)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   3  (bases 1 to 9080)
  AUTHORS   Pei,L., Leblanc,M., Barish,G., Atkins,A., Nofsinger,R., Whyte,J.,
            Gold,D., He,M., Kawamura,K., Li,H.R., Downes,M., Yu,R.T.,
            Powell,H.C., Lingrel,J.B. and Evans,R.M.
  TITLE     Thyroid hormone receptor repression is linked to type I
            pneumocyte-associated respiratory distress syndrome
  JOURNAL   Nat Med 17 (11), 1466-1472 (2011)
   PUBMED   22001906
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9080)
  AUTHORS   Sircoulomb,F., Nicolas,N., Ferrari,A., Finetti,P., Bekhouche,I.,
            Rousselet,E., Lonigro,A., Adelaide,J., Baudelet,E., Esteyries,S.,
            Wicinski,J., Audebert,S., Charafe-Jauffret,E., Jacquemier,J.,
            Lopez,M., Borg,J.P., Sotiriou,C., Popovici,C., Bertucci,F.,
            Birnbaum,D., Chaffanet,M. and Ginestier,C.
  TITLE     ZNF703 gene amplification at 8p12 specifies luminal B breast cancer
  JOURNAL   EMBO Mol Med 3 (3), 153-166 (2011)
   PUBMED   21328542
  REMARK    Erratum:[EMBO Mol Med. 2011 Mar;3(3). doi:10.1002/emmm.201000121]
REFERENCE   5  (bases 1 to 9080)
  AUTHORS   Cui,J., Yang,Y., Zhang,C., Hu,P., Kan,W., Bai,X., Liu,X. and
            Song,H.
  TITLE     FBI-1 functions as a novel AR co-repressor in prostate cancer cells
  JOURNAL   Cell Mol Life Sci 68 (6), 1091-1103 (2011)
   PUBMED   20812024
REFERENCE   6  (bases 1 to 9080)
  AUTHORS   Martinez de Arrieta,C., Koibuchi,N. and Chin,W.W.
  TITLE     Coactivator and corepressor gene expression in rat cerebellum
            during postnatal development and the effect of altered thyroid
            status
  JOURNAL   Endocrinology 141 (5), 1693-1698 (2000)
   PUBMED   10803578
REFERENCE   7  (bases 1 to 9080)
  AUTHORS   Zhou,S., Fujimuro,M., Hsieh,J.J., Chen,L., Miyamoto,A.,
            Weinmaster,G. and Hayward,S.D.
  TITLE     SKIP, a CBF1-associated protein, interacts with the ankyrin repeat
            domain of NotchIC To facilitate NotchIC function
  JOURNAL   Mol Cell Biol 20 (7), 2400-2410 (2000)
   PUBMED   10713164
REFERENCE   8  (bases 1 to 9080)
  AUTHORS   Park,E.J., Schroen,D.J., Yang,M., Li,H., Li,L. and Chen,J.D.
  TITLE     SMRTe, a silencing mediator for retinoid and thyroid hormone
            receptors-extended isoform that is more related to the nuclear
            receptor corepressor
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3519-3524 (1999)
   PUBMED   10097068
REFERENCE   9  (bases 1 to 9080)
  AUTHORS   Ordentlich,P., Downes,M., Xie,W., Genin,A., Spinner,N.B. and
            Evans,R.M.
  TITLE     Unique forms of human and mouse nuclear receptor corepressor SMRT
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2639-2644 (1999)
   PUBMED   10077563
REFERENCE   10 (bases 1 to 9080)
  AUTHORS   Misiti,S., Schomburg,L., Yen,P.M. and Chin,W.W.
  TITLE     Expression and hormonal regulation of coactivator and corepressor
            genes
  JOURNAL   Endocrinology 139 (5), 2493-2500 (1998)
   PUBMED   9564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006249305.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000012.1  37127735-37127957
            224-269             JAXUCZ010000012.1  37153729-37153774
            270-480             JAXUCZ010000012.1  37181505-37181715
            481-608             JAXUCZ010000012.1  37186661-37186788
            609-786             JAXUCZ010000012.1  37187461-37187638
            787-966             JAXUCZ010000012.1  37195992-37196171
            967-1080            JAXUCZ010000012.1  37199919-37200032
            1081-1137           JAXUCZ010000012.1  37203554-37203610
            1138-1190           JAXUCZ010000012.1  37208308-37208360
            1191-1257           JAXUCZ010000012.1  37214776-37214842
            1258-1430           JAXUCZ010000012.1  37218299-37218471
            1431-1524           JAXUCZ010000012.1  37219313-37219406
            1525-1703           JAXUCZ010000012.1  37221026-37221204
            1704-1758           JAXUCZ010000012.1  37224761-37224815
            1759-1857           JAXUCZ010000012.1  37226642-37226740
            1858-2015           JAXUCZ010000012.1  37236892-37237049
            2016-2188           JAXUCZ010000012.1  37238062-37238234
            2189-2251           JAXUCZ010000012.1  37240123-37240185
            2252-2394           JAXUCZ010000012.1  37249760-37249902
            2395-2542           JAXUCZ010000012.1  37254466-37254613
            2543-2596           JAXUCZ010000012.1  37256119-37256172
            2597-3194           JAXUCZ010000012.1  37257021-37257618
            3195-3315           JAXUCZ010000012.1  37262715-37262835
            3316-3487           JAXUCZ010000012.1  37263588-37263759
            3488-3652           JAXUCZ010000012.1  37266394-37266558
            3653-3789           JAXUCZ010000012.1  37267421-37267557
            3790-3895           JAXUCZ010000012.1  37268044-37268149
            3896-4000           JAXUCZ010000012.1  37268259-37268363
            4001-4098           JAXUCZ010000012.1  37268502-37268599
            4099-4249           JAXUCZ010000012.1  37270589-37270739
            4250-4390           JAXUCZ010000012.1  37272343-37272483
            4391-4471           JAXUCZ010000012.1  37272774-37272854
            4472-4767           JAXUCZ010000012.1  37273219-37273514
            4768-5179           JAXUCZ010000012.1  37274384-37274795
            5180-5401           JAXUCZ010000012.1  37275932-37276153
            5402-5656           JAXUCZ010000012.1  37276604-37276858
            5657-5806           JAXUCZ010000012.1  37277625-37277774
            5807-5938           JAXUCZ010000012.1  37277883-37278014
            5939-6125           JAXUCZ010000012.1  37278098-37278284
            6126-6655           JAXUCZ010000012.1  37279776-37280305
            6656-6808           JAXUCZ010000012.1  37281155-37281307
            6809-6954           JAXUCZ010000012.1  37281397-37281542
            6955-7148           JAXUCZ010000012.1  37281763-37281956
            7149-7295           JAXUCZ010000012.1  37282623-37282769
            7296-7441           JAXUCZ010000012.1  37283278-37283423
            7442-7495           JAXUCZ010000012.1  37283997-37284050
            7496-7723           JAXUCZ010000012.1  37286783-37287010
            7724-7903           JAXUCZ010000012.1  37287848-37288027
            7904-9080           JAXUCZ010000012.1  37288437-37289613
FEATURES             Location/Qualifiers
     source          1..9080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..9080
                     /gene="Ncor2"
                     /note="nuclear receptor co-repressor 2"
                     /db_xref="GeneID:360801"
                     /db_xref="RGD:1310293"
     exon            1..223
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..269
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..480
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    277..279
                     /gene="Ncor2"
                     /note="upstream in-frame stop codon"
     CDS             376..8085
                     /gene="Ncor2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear receptor corepressor 2"
                     /codon_start=1
                     /product="nuclear receptor corepressor 2 isoform 1"
                     /protein_id="NP_001424500.1"
                     /db_xref="GeneID:360801"
                     /db_xref="RGD:1310293"
                     /translation="MSGSTQPVAQTWRAAEPRYPPHGISYPVQIARPHTDVGLLEYQH
                     HPRDYTSHLSPGSIIQPQRRRPSLLSEFQPGSERSQELHLRPESRTFLPELGKPDIEF
                     TESKRPRLELLPDTLLRPAPLLATGQPSGSEDLTKDRSLAGKLEPVSPPSPPHADPEL
                     ELTPSRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPP
                     IESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAM
                     RKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYE
                     KQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQL
                     AVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKN
                     FGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQ
                     QQQMARSSQEEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVAS
                     KGRKTANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAK
                     KGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRK
                     KKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEASQASGNEVPRVGECSGP
                     AAVNNSSDTESVPSPRTEATKDAGPKPASTEALPAATQPPVPPPEEPATVPDEPCPAP
                     DASGPPSPVASPPPAAPPAAVDKDEQDQAATVPQTEDAKEQKSEAEELVIDVGKTEEP
                     EAPEEPPESVKSDHKEETEEEPEDKAKGPEAIETVSEAPLKVEEAGSKAAVTKGSSSG
                     ATQDSDSSATCSADEVDEPEGGDKGRLLSPRPSLLTPAGDPRASTSPQKPLDLKQLKQ
                     RAAAIPPIQVTKVHEPPREDTVPPKPAPPVPPPTQHLQPEGDVSQQSGGSPRGKCRSP
                     VPPAEKEAEKASFFPAFPAEGPKLPTEPPRWTSGLPFPIPPREVIKTSPHAADPSAFS
                     YTPPGHPLPLGLHDSARPVLPRPPISNPPPLISSAKHPGVLERQLGTISQQGMSVQLR
                     VPHSEHAKAPMGPLTMGLPLAVDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQET
                     SVLRGTALGSTASGSITKGLPSTRTADGPSYRGSITHGTPADVLYKGTISRIVGEDSP
                     SRLDRAREDTLPKGHVIYEGKKGHVLSYEGGMSVSQCSKEDGRSSSGPPHETAAPKRT
                     YDMMEGRVGRTITSASIEGLMGRAIPEQHSPHLKEQHHIRGSITQGIPRSYVEAQEDY
                     LRREAKLLKREGTPPPPPPPRDLTETYKTRPLDPLGPLKLKPTHEGVVATVKEAGRSI
                     HEIPREELRRTPELPLAPRPLKEGSITQTYRENSIWPATYRPGPSPQGTPLKYDSGVP
                     SSGSKKHDVRSIIGSPGRPFPALHPLDIMADARALERACYEESLKSRSGTSSGAGGSI
                     TRGAPVVVPELGKPRQSPLAYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKAS
                     QDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVTGVDLYRGHIPLAFDPTSIP
                     RGIPLEAAAAAYYLPRHLAPSPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQM
                     HHNAASAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPAT
                     AIDRLAYLPTAPPPFSSRHSSSPLSPGGPTHLAKPTATSSSERERERERERDKSILTS
                     TTTVEHAPIWRPGTEQSSGAGGSSRPASHTHQHSPISPRTQDALQQRPSVLHNTSMKG
                     VVTSVEPGTPTVLRWARSTSTSSPVRPAATFPPATHCPLGGTLEGVYPTLMEPVLLPK
                     ETSRVTRPERPRVDAGHAFLTKPPAREPASSPSKSSEPRSLAPPSSSHTAIARTPAKS
                     LAPHHASPDLPAPTSASDLHREKTQSKPFSIQELELRSLGKTTLTAATFIDAIITRQI
                     AHERGPREGGSLAIDSPGDGYHSGAGYSPDGVEPISPVSSPSLTHDKGLSKPLEELEK
                     SHLEGELRHKQPGPMKLSGEAAHLPHLRPLPESQPSSSPLLQTAPGIKGHQRVVTLAQ
                     HISEVITQDYTRHHPQQLSGPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGTPAR
                     GSPHSEGGKRSPEPSKTVLSSSEDAIEPVSPPEGMTEPGHARSTAYPLLYRDGEQGEP
                     RMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNIGQPGTEI
                     FNMPAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMGKYDQWEEPPPLGANAFNPL
                     NASASLPAAAMPITTADGRSDHPLTSPGGGGKAKVSGRPSSRKAKSPAPGLAPGDRPP
                     SVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLAA
                     GSGPLAGPHHAWDEEPKPLLCSQYETLSDSE"
     misc_feature    802..1062
                     /gene="Ncor2"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     Region: GPS2_interact; pfam15784"
                     /db_xref="CDD:464868"
     misc_feature    802..1062
                     /gene="Ncor2"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     Region: GPS2_interact; pfam15784"
                     /db_xref="CDD:464868"
     misc_feature    850..>1590
                     /gene="Ncor2"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    850..>1590
                     /gene="Ncor2"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    1669..1800
                     /gene="Ncor2"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl21498"
                     /db_xref="CDD:473887"
     misc_feature    1669..1800
                     /gene="Ncor2"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl21498"
                     /db_xref="CDD:473887"
     misc_feature    order(1669..1671,1756..1761,1765..1770,1774..1782,
                     1786..1794)
                     /gene="Ncor2"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    order(1669..1671,1756..1761,1765..1770,1774..1782,
                     1786..1794)
                     /gene="Ncor2"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212559"
     misc_feature    <1990..>2322
                     /gene="Ncor2"
                     /note="RSC chromatin remodeling complex subunit RSC8
                     [Chromatin structure and dynamics / Transcription];
                     Region: RSC8; COG5259"
                     /db_xref="CDD:227584"
     misc_feature    <1990..>2322
                     /gene="Ncor2"
                     /note="RSC chromatin remodeling complex subunit RSC8
                     [Chromatin structure and dynamics / Transcription];
                     Region: RSC8; COG5259"
                     /db_xref="CDD:227584"
     misc_feature    2215..2346
                     /gene="Ncor2"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-binding; pfam00249"
                     /db_xref="CDD:459731"
     misc_feature    2215..2346
                     /gene="Ncor2"
                     /note="Myb-like DNA-binding domain; Region:
                     Myb_DNA-binding; pfam00249"
                     /db_xref="CDD:459731"
     misc_feature    <5698..6471
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5698..6471
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <6124..7338
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <6124..7338
                     /gene="Ncor2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            481..608
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..786
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..966
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1080
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1137
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1190
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1257
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1430
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1524
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1703
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1758
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1857
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2015
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2188
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2251
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2394
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2542
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2596
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..3194
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3315
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3487
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3652
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3789
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3895
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4000
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4098
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4249
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4250..4390
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4471
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4767
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            4768..5179
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5401
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..5656
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5657..5806
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5807..5938
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            5939..6125
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6126..6655
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6656..6808
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6809..6954
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            6955..7148
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7149..7295
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7296..7441
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7442..7495
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7496..7723
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7724..7903
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
     exon            7904..9080
                     /gene="Ncor2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccagga gcggagccgc gggcagcgca ggccgggccg catccccgta cccgcgccag
       61 ccgcccgcgc ccgccatgcg cgccccgcag cggcccgcgc gcccgggccc cgcgtcgtag
      121 cgcggcgggc ggagaccgca ggctcctagc cggtgcccgc cgcgtcctcg agcccgatcg
      181 gcgccgtagc ccggcgccag cgcccggtgc cgccgccggc gagcgctcct gagtctttga
      241 ggaacacagc ctcccggtgg aagtttctgg tacctgtgac gaggtcaccg gccagcagat
      301 gaccgagacc agcccctagt cctaggtgtg gtcaagagtg tattgggttc caaagccttc
      361 ctggacccta ccaccatgtc aggatccaca cagcctgtgg cacagacatg gcgggctgct
      421 gagccccgct acccacccca tggcatctcc tacccggtgc agatagcccg gccccacacg
      481 gacgtggggc tgcttgagta ccaacaccac cctcgtgact acacctcaca cctgtcaccc
      541 ggctccatta tccagccaca gaggaggcgg ccctcactgc tatctgagtt ccagcctgga
      601 agtgaacggt ctcaggagct ccacctgcgc cctgagtctc gcaccttcct gcctgaactg
      661 ggcaagcccg acatagaatt cacagagagc aagcgcccac gcctggagct actacctgat
      721 accctgctgc gcccggcacc cctgctggcc actgggcagc caagtgggtc tgaagatctt
      781 accaaggacc gcagcctggc aggcaagctg gagcccgtgt cacctcccag cccaccacac
      841 gctgaccctg agctagagct gacgccatct cggctgtcca aggaggagct gatccagaac
      901 atggaccgtg tggaccgtga gatcaccatg gtggagcagc agatctccaa gctgaagaag
      961 aagcagcaac agttggagga ggaggccgcc aagccacccg agcccgagaa gccggtgtcg
     1021 ccaccaccca tagaatcaaa gcaccgcagt ctggtccaga tcatctacga cgagaaccgg
     1081 aagaaagccg aagctgcaca ccgcatcctg gaagggctgg ggccccaggt ggagctgcct
     1141 ctgtacaacc agccgtccga cacacgccag taccatgaga acatcaaaat aaaccaggcg
     1201 atgcggaaga agctgatctt gtacttcaag cggaggaacc acgcacgcaa gcagtgggag
     1261 cagcgcttct gccagcgcta tgaccagctc atggaggcat gggagaagaa ggtggagcgc
     1321 attgagaaca atccgcggag aagggccaag gagagcaagg tgagggagta ctacgagaaa
     1381 cagttcccgg agatccgcaa gcagcgggag ctgcaggagc gcatgcagag cagggtgggc
     1441 cagcgtggca gtgggctctc catgtcggcg gcacgcagtg agcatgaggt ttctgagatc
     1501 atcgatggct tgtctgagca ggagaacctg gagaagcaga tgcgccagct ggctgtgatc
     1561 ccgcccatgt tgtacgatgc ggaccagcag aggatcaagt tcatcaacat gaacggactc
     1621 atggacgacc ccatgaaggt gtacaaagac cgccaggtta ccaacatgtg gagtgagcag
     1681 gagagggaca ccttccgcga gaagttcatg cagcatccca agaactttgg cctgatcgcc
     1741 tcattcctgg agagaaagac agtagccgag tgtgtcctct attactacct gaccaagaag
     1801 aatgagaact acaagagctt ggtgaggcgc agctatcggc gccgtggcaa gagtcagcag
     1861 cagcagcagc agcaacagca gcagcaacag cagcagcagc agcagcagat ggcacggagc
     1921 agccaggagg agaaggagga gaaggagaag gagaaggaag ccgacaagga ggaggagaag
     1981 caggatgcgg agaacgagaa ggaagaactc agcaaggaga agacagacga cacttctgga
     2041 gaggacaacg atgagaaaga ggctgtggcc tccaaaggcc gcaaaactgc caacagccaa
     2101 ggccgccgca aaggccggat cacacgctcc atggccaacg aggccaacca tgaggagacg
     2161 gccaccccgc agcaaagttc agagctagct tccatggaga tgaacgagag ctctcgctgg
     2221 actgaggaag agatggagac agcaaagaaa ggcctcctgg aacatgggag gaactggtca
     2281 gccatcgccc gcatggtggg ctccaagact gtgtcccagt gtaagaactt ttacttcaac
     2341 tacaagaaga ggcagaacct ggacgaaatc cttcagcagc acaagctaaa gatggagaag
     2401 gagaggaatg cccggaggaa gaaaaagaag accccggctg cggcaagtga ggagacagcc
     2461 ttcccacctg ccgctgagga cgaagagatg gaggcgtctg gtgcaagtgc caatgaggaa
     2521 gaactggcgg aggaggcaga agcctcacag gcctccggga atgaggttcc cagagttgga
     2581 gagtgcagtg gcccagctgc tgtcaacaac agctctgata ctgagagtgt cccatccccg
     2641 cgcacggaag ccaccaagga cgctggtcct aagcctgcta gcactgaagc attgcccgct
     2701 gccacccagc cacctgttcc tcctccagaa gaacccgcaa cagtccctga tgagccctgc
     2761 ccagcccctg atgccagtgg cccaccatcc ccagtggctt ccccaccacc tgccgcaccc
     2821 ccggctgctg ttgacaagga tgaacaagac caggctgcta ctgttcccca gaccgaggat
     2881 gccaaggagc agaagtctga ggccgaggag ctggtgattg atgtgggaaa gacagaggaa
     2941 cccgaggccc ctgaggagcc accagagagt gtaaagagtg atcacaagga ggagactgag
     3001 gaggagcctg aagacaaagc caagggccca gaggccattg agactgtgtc cgaggcgcca
     3061 cttaaggtgg aggaggctgg aagcaaggca gctgtgacca agggttccag ctcgggtgcc
     3121 acccaggaca gtgactccag tgccacctgc agtgccgatg aggtggatga gcccgaggga
     3181 ggtgacaagg gcaggctgct gtcaccaagg cccagcctcc tcaccccagc cggagatccc
     3241 cgggccagta cctcgcccca gaagccgctg gacctgaagc agctgaagca gcgagcagca
     3301 gccatccccc ctattcaggt caccaaggtc catgaacccc cccgggagga cacagtaccc
     3361 ccaaagccag ctccccctgt gcctccaccc acgcagcacc tacagccaga gggtgacgtg
     3421 tctcagcagt cgggaggaag tccacgtggc aagtgccgca gcccggtgcc tcccgccgag
     3481 aaagaggcag agaaagcttc attctttccc gccttcccag ctgagggccc gaagcttcct
     3541 actgagcccc cacgctggac atcgggtctg ccttttccca ttcctcctcg ggaagtgatc
     3601 aagacttccc cacacgctgc agacccctct gccttctcct acacaccccc tggtcaccct
     3661 ctgcctctgg gcctccacga tagtgcccgg ccggtcctgc cacgtccccc catctctaac
     3721 cccccacccc tcatctcctc tgccaagcac cctggtgtac ttgagaggca gctgggtacc
     3781 atctcccagc agggaatgtc agtgcagctt cgcgtgcccc actcagagca tgccaaggcc
     3841 cccatgggcc ctctcaccat gggactgcct ctcgctgtgg accctaagaa gctggccccc
     3901 ttcagtggag tgaagcagga gcagttgtcc cctcggggtc aggctgggcc acctgaaagt
     3961 ctgggagtgc ctactgctca ggagacctct gtgctaagag ggacagcact gggctccact
     4021 gccagtggaa gcatcaccaa gggcctcccc agtacccgga ctgcagatgg ccccagctac
     4081 cgaggctcta tcacccacgg cacgccagca gacgtcctct acaagggtac catcagcagg
     4141 atcgttggtg aggacagccc aagtcgcctt gatcgggcac gagaggatac cctgcccaag
     4201 ggccatgtca tctatgaggg caagaaaggc catgtcctat cctatgaagg tggtatgtcg
     4261 gtgtcacagt gctccaagga ggatgggagg agcagctcag gcccacccca cgagactgcc
     4321 gcccctaaac gcacctatga catgatggag ggccgtgtgg gcaggaccat cacctcagcc
     4381 agcatcgagg gactcatggg ccgtgccatc cctgagcagc acagccccca cctcaaggag
     4441 caacatcaca tccgaggctc catcacgcaa ggcatcccga ggtcatatgt ggaggcccag
     4501 gaggactact tacgtaggga ggccaagctc ttgaagcgag aaggcacgcc accgccccca
     4561 ccgccacctc gggacctgac tgagacctac aagacccggc ccctcgaccc tctgggtccc
     4621 ctgaagctga agccaactca tgagggtgtg gtagcgactg tgaaggaggc gggccgctct
     4681 atccatgaga tcccacgaga ggagctgcgc cgcacgcccg agctgcccct ggcaccacgg
     4741 cctctgaagg agggttccat cacccagaca tacagggaga acagcatctg gccagccaca
     4801 tacagacctg gaccctctcc ccaggggacc ccactcaagt acgactccgg ggtgccctcc
     4861 agtggctcca agaaacacga cgtacgctcc atcatcggca gccccggccg gccttttcct
     4921 gccctgcacc cactggacat aatggctgat gcccgggcac tagagcgcgc ctgctatgaa
     4981 gagagtctga agagccggtc agggaccagc agtggtgcag ggggctccat cacacgcggg
     5041 gccccagttg tcgtgcctga gctaggcaag ccccggcaaa gcccactggc ctacgaggac
     5101 cacggggcac ccttcaccag ccacctgccc cgaggctcac ctgtgactac cagggagccc
     5161 acgccacgcc ttcaggaagg cagcctcctc tccagcaagg cgtcccagga ccggaagctg
     5221 acctcgacac cccgggagat tgccaagtcc ccacatagca ctgtgcccga gcaccacccc
     5281 caccccatct ccccctacga gcacctgctc cggggtgtga ctggtgtgga cctgtaccgt
     5341 ggccacatcc cattggcctt tgaccccacc tccatacccc gagggatccc tctggaagca
     5401 gcagccgcag cctactacct gccccggcac ttggccccca gccccaccta cccacacctg
     5461 tacccgcctt acctcatccg cggctaccct gacaccgcgg ccctggagaa ccgccagacc
     5521 atcatcaatg actacatcac ctcgcagcag atgcaccaca acgcagcctc tgccatggcc
     5581 cagcgcgccg atatgctgag gggtctgtca ccgagagagt cctcgctggc cctcaattat
     5641 gccgctggcc cgcgtggcat tatcgacctg tcccaagtgc cacacctgcc cgtgctggtg
     5701 ccgccaactc caggcacccc tgccaccgcc atcgaccgcc ttgcctacct ccccactgcg
     5761 cccccaccct tcagcagccg tcacagcagt tcaccactgt ccccaggagg ccccactcac
     5821 ctagctaaac caactgccac gtcatcatcg gagcgggaac gggaacgaga gcgagaacga
     5881 gacaagtcca tcctcacgtc caccactaca gtggagcatg cacccatctg gagacctggt
     5941 acggagcaga gcagcggggc tgggggcagc agccgccccg cctcccacac ccaccagcac
     6001 tcgcccatct ccccccggac ccaggacgcc ttgcagcaga ggcccagtgt gctgcacaac
     6061 acgagcatga agggcgtggt cacctccgtg gaacccggca cgcccacggt cctgaggtgg
     6121 gccaggtcca cctccacctc ttcacctgtc cgcccagctg ccacattccc acctgccacc
     6181 cactgcccac ttggtggcac cctcgaaggg gtctacccta ccctcatgga gccagtcctg
     6241 ttacccaagg agacctctcg ggttacccgg cctgagcggc cccgtgtgga cgctggccat
     6301 gccttcctca ccaagccccc agcccgggag cctgcctcct cacccagcaa gagctccgaa
     6361 ccccgatccc tagcaccccc cagctccagc cacacagcca tcgcccgcac cccagcaaag
     6421 agccttgcac cccaccatgc cagtccggac ctgccggcgc ccacctcggc ctcagatctg
     6481 caccgagaaa agactcaaag taaacccttt tccatccagg aattggaact ccgttctctg
     6541 ggtaagacca ccctgacagc ggccacgttc atagacgcaa taatcacgcg tcaaattgct
     6601 cacgaaaggg ggccgcgaga aggaggttcg ctggccatcg actcccctgg cgacggttac
     6661 cacagtggag ctggctacag ccctgatggg gtagagccca tcagccccgt gagctcgccc
     6721 agcctgaccc acgacaaggg gctctccaag cctctggaag agctagagaa gagccacttg
     6781 gagggggagc tgcggcacaa gcagccaggc cccatgaagc tcagtgggga ggctgcccac
     6841 ctcccacatc tgcggccact gccggagagc cagccctcat ccagcccact cctccagact
     6901 gccccaggca tcaaaggtca ccagagggtg gtcaccttgg ctcagcacat cagtgaggtc
     6961 attacacagg actacacacg ccaccaccca cagcagctca gtggccccct tcccgcccct
     7021 ctctactcct tccctggagc cagctgccct gtcctggatc tccgccgtcc acccagtgac
     7081 ctctacctcc cacccccgga ccatggcacc ccagcccggg gatcccccca cagtgaaggg
     7141 ggcaaaaggt ctccagaacc cagcaaaaca gtcctgagta gcagcgagga tgctattgaa
     7201 cctgtgtccc caccggaggg catgactgag ccaggacatg cacggagcac tgcgtaccca
     7261 ctgctgtacc gggacgggga gcagggggag cccaggatgg gttctaagtc tccaggcaac
     7321 accagccagc cgccagcctt cttcagtaag ctgaccgaga gcaactccgc catggtgaag
     7381 tcgaagaagc aggagatcaa caagaaactc aacacccata accggaatga gcctgaatac
     7441 aatatcggcc agcctgggac ggaaatcttc aacatgcccg ccatcactgg agcaggcctt
     7501 atgacctgta gaagccaggc ggtgcaagaa cacgccagca ccaacatggg gctagaggcc
     7561 attattagaa aggcactcat gggtaaatat gatcagtggg aagagccccc gccgctcggc
     7621 gccaatgctt ttaaccctct gaatgccagt gccagtctgc ccgctgccgc tatgcccata
     7681 accactgctg acggacggag tgaccaccca ctcacctcgc caggtggtgg tgggaaagcc
     7741 aaggtttctg gcagacccag cagccgaaaa gccaagtcgc cagcgccagg cctggcaccc
     7801 ggagaccgac caccttctgt ctcctcagta cactcggagg gcgactgcaa tcgccgaaca
     7861 ccactcacca accgtgtgtg ggaggaccgg ccctcatctg cagggtccac gccattcccc
     7921 tacaaccctt tgattatgag gctacaggca ggtgtcatgg cctccccacc cccacctggc
     7981 cttgccgcag gcagcgggcc cctagctggt ccccaccatg cctgggatga ggagcccaag
     8041 ccactgctgt gttcacagta cgagacactc tcggacagcg agtgaccaca gattgggggg
     8101 gagcggtgcc aggtccctgc acgaggcaga agcagcccag catggagcag acagctgcca
     8161 actcccccga ctgaggaagg agcccctgaa tctgcctgcg cgtccatccg tccgtccgtc
     8221 tactcatctg tccatccaga gctggcatcc tgcctgtcta aagccttaac taagactccc
     8281 gccccgggct ggccctgcgc agtgacctta cactcagggg atgtttacct ggtgctcgag
     8341 aggggagtgg acaggagggg aggccagcgg gccgggagag gggtacagtg atcgtgtgtc
     8401 agttgcacgc gtgcatctgg ggcagcgggg acccaacaca ggatgaccag gcacctccat
     8461 gccactgcct cgccccttac cgcatttgga accaaagtct aagctgagct cgcggccctg
     8521 cccctccctc tgcccccagc ccgctcgcgc tctggacaga cagacgttcc cagcttatcc
     8581 tgccccatcg ctgtcatcgc agtccccaaa ggccacccag cccacaagac tgggagccca
     8641 tcagaccagg tgggtgcaca aagggccggg tatggcctgg ggcacggatg tttgcaggaa
     8701 ccggaccgtt cattcccggc ctgtcgctat ggcgatggcg gggaaggcag gtgtaaatgg
     8761 tgttggctta cagggtatat ttttgatacc ttcaatgagt taattcagtc gcttcacaca
     8821 aggaaggact cacccgtgtt actgccgctg tgctttggtc tctgcttcct gtcccagagg
     8881 catgtgccgg ccaaggcggt ggccccacca tacgcaggac tggggggcag gggctccggc
     8941 acacggcact gtgccctccc cctcccttcc ttgggcagaa tggacttgat gcgtattctg
     9001 tggccgctct ctgcacggcg gcattctgtc atttacacat gttgttccaa ttaaaaggca
     9061 aattatactc cagttacaaa
//
LOCUS       NM_001105970            2449 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus nescient helix loop helix 1 (Nhlh1), transcript
            variant 1, mRNA.
ACCESSION   NM_001105970 XM_001055226 XM_222898
VERSION     NM_001105970.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2449)
  AUTHORS   Manetopoulos,C., Hansson,A., Karlsson,J., Jonsson,J.I. and
            Axelson,H.
  TITLE     The LIM-only protein LMO4 modulates the transcriptional activity of
            HEN1
  JOURNAL   Biochem Biophys Res Commun 307 (4), 891-899 (2003)
   PUBMED   12878195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 24, 2025 this sequence version replaced NM_001105970.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.940433.1,
                                           SRR22582416.719706.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               JAXUCZ010000013.1  87054622-87054933   c
            313-2449            JAXUCZ010000013.1  87049735-87051871   c
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2449
                     /gene="Nhlh1"
                     /note="nescient helix loop helix 1"
                     /db_xref="GeneID:289230"
                     /db_xref="RGD:1310261"
     exon            1..312
                     /gene="Nhlh1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..2449
                     /gene="Nhlh1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    336..338
                     /gene="Nhlh1"
                     /note="upstream in-frame stop codon"
     CDS             483..884
                     /gene="Nhlh1"
                     /codon_start=1
                     /product="helix-loop-helix protein 1"
                     /protein_id="NP_001099440.1"
                     /db_xref="GeneID:289230"
                     /db_xref="RGD:1310261"
                     /translation="MMLNSDTMELDLPPTHSETESGFSDCGGGPGPDGAGSGDPGVGQ
                     VRSLELGESGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLL
                     PTLPPDKKLSKIEILRLAICYISYLNHVLDV"
     misc_feature    663..878
                     /gene="Nhlh1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     helix-loop-helix protein 1 (HEN-1) and similar proteins;
                     Region: bHLH_TS_HEN1; cd19701"
                     /db_xref="CDD:381544"
     misc_feature    663..878
                     /gene="Nhlh1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     helix-loop-helix protein 1 (HEN-1) and similar proteins;
                     Region: bHLH_TS_HEN1; cd19701"
                     /db_xref="CDD:381544"
     misc_feature    order(711..713,723..725,729..737,741..743,756..758,
                     810..821)
                     /gene="Nhlh1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(711..713,723..725,729..737,741..743,756..758,
                     810..821)
                     /gene="Nhlh1"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(750..755,762..767,771..776,822..824,831..833,
                     843..845,849..854,864..866,870..875)
                     /gene="Nhlh1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381544"
     misc_feature    order(750..755,762..767,771..776,822..824,831..833,
                     843..845,849..854,864..866,870..875)
                     /gene="Nhlh1"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381544"
ORIGIN      
        1 aggtgtgtga atgtgcggtg agtgtgtgaa tgtgtgggtg tgtgagtgtg tgcatgtacg
       61 tatgagtgtg cgtgtgagtg actccagttc cggattgagg ccatccctcc tgcctaggcc
      121 ttcaggatgt gtacccttct catccgtcct ggatcctgtt cagccacaac aagctgcccc
      181 taagagctct agaaactgct cactaacttt gcagacagat gacccttgag cagcgagaag
      241 agactggggc tctccacgct cgcttgctgt ccccctcact tgtcaccttg gattcctgga
      301 gagtccttct aggctccagg ctggaatctt gaccatgaaa ctttgaagta actgctttcc
      361 agagctcagt ggcagaccct agcactcgag gcccttcctg cctttctcac aaccctcttt
      421 caagctccca aagggagggg tggggagagg atccgcattt ccataggtgt ggattttcca
      481 ccatgatgct caactccgac accatggagc tggatcttcc tcccacgcac tcggagaccg
      541 agtcgggctt tagcgactgt gggggcgggc cgggcccgga tggtgctgga tcgggcgatc
      601 cgggagtggg ccaggtccgg agcttagagc tcggagagtc cggccgcaaa gacctgcagc
      661 acttgagccg tgaggagcgc aggcgccggc gccgcgccac ggccaagtac cgcacagcgc
      721 acgccacgcg ggagcgcatc cgcgtggaag ccttcaacct ggccttcgcc gagctgcgca
      781 agctgctgcc cactctgccc ccggacaaga aactctccaa gattgagatc ctgcgcctgg
      841 ccatctgcta tatctcttac ctgaaccacg tgctggatgt ctgaactcag tccgaatccg
      901 gccctggatt ctcccctttt ccctgggcct ctccagagcc ccttgtcacc atgcattact
      961 tagaatggcc ggctgctgcc catcccagag caccaggctc ccgtccgtcc tgaaggccac
     1021 tttcttttct ttggcccagg aatgtgaagg atgttcttaa gggttccttc agagagttgt
     1081 tcgggcctag ctggtcaggg ttgcttgtca gagtggtcag aatggagtcc ttgctgggtt
     1141 aactaagcct agcctctact cagctgctgc cttttctgcc ccatgtccaa gttttcagag
     1201 accccagacc ctgactctgt cttctgacaa tggtgggact cagcagaata ggaaggggaa
     1261 ctgactagta gcagaggttg ggcaaacggg gttcctaact cccagacttg tctgtccatg
     1321 cgggggtggg ggagggaggg catggactct tgggaaggca gagagatgag ggaggtgact
     1381 cctgggtagc cagggattat aggaaaattc ttccctttgt ctctcttgct cctgaggctt
     1441 aggatatata gacctcagat ctaacttggt agtgagtgcc ttgccttcct ggagctgact
     1501 ggccactccc cgggtccctt cccacacctg ccatcccaga attctccctt tccctgtgct
     1561 gtctagagaa aggaacacct cagccctggg ataaggagga cacctccaaa cagcccaggg
     1621 caccttgcag aaggctcagg ccctgagtgg ggcagctctt cagccgctgc ttctgtccca
     1681 gtggaccctt gaaaacatgc gaaccccacc agctcctccc tcagacgcag gaggatgcct
     1741 gcgactgccc tctgcgaagg atctagggcc ttattacatt tcccccttcc attcttaaat
     1801 tgccgtgggc aggaaggtgc ccctcccccc ccatgctgct gagcctacca gcccttgtag
     1861 cctgtgacct cggtctctgg gctttagact ccctgtagat gaagtcactg cttttctctg
     1921 ctccgtccac tctcacacca aactcctagc tctacaagga tatttattta tgtatttatt
     1981 tattcactta tttatttatt tatttataaa tattactatt tattaccgag ttatgcactt
     2041 tggggtaggg cgaggagggc tccttgcagc gagctctagc tagggtcctc ttgctttctc
     2101 ccgggtcact tcttccttct ccagtgcaag cgtgggggtg gggatccctt cacccaccat
     2161 actggtacgc cttcctcagc tccatctgtc tctgtcccct ttcctctgga atagtgcccc
     2221 ttcccagcct cccagcttcc gggggtctct ctcaatctct gccccccaat cctgacaatc
     2281 ccacttcagt cctatctact ccattcctct ttaccagccc tgctttttcc aatatcacta
     2341 ggagcagacc ccgggctctg tgtctagtgt cctgtgtgga agtctttgtc tggttgcatt
     2401 cctactttct tacaaaaaga aaaattaaag tgacctcgat ctagtacca
//
LOCUS       NM_001437471            8008 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus golgin A3 (Golga3), transcript variant 1, mRNA.
ACCESSION   NM_001437471 XM_006249563
VERSION     NM_001437471.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8008)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8008)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 8008)
  AUTHORS   Ohta,E., Misumi,Y., Sohda,M., Fujiwara,T., Yano,A. and Ikehara,Y.
  TITLE     Identification and characterization of GCP16, a novel acylated
            Golgi protein that interacts with GCP170
  JOURNAL   J Biol Chem 278 (51), 51957-51967 (2003)
   PUBMED   14522980
REFERENCE   4  (bases 1 to 8008)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   5  (bases 1 to 8008)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   6  (bases 1 to 8008)
  AUTHORS   Fritzler,M.J., Hamel,J.C., Ochs,R.L. and Chan,E.K.
  TITLE     Molecular characterization of two human autoantigens: unique cDNAs
            encoding 95- and 160-kD proteins of a putative family in the Golgi
            complex
  JOURNAL   J Exp Med 178 (1), 49-62 (1993)
   PUBMED   8315394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006249563.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.345643.1,
                                           SRR26643293.85937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000012.1  52159888-52159934   c
            48-366              JAXUCZ010000012.1  52155150-52155468   c
            367-636             JAXUCZ010000012.1  52152649-52152918   c
            637-749             JAXUCZ010000012.1  52149148-52149260   c
            750-1396            JAXUCZ010000012.1  52147114-52147760   c
            1397-1508           JAXUCZ010000012.1  52145672-52145783   c
            1509-1815           JAXUCZ010000012.1  52143096-52143402   c
            1816-2018           JAXUCZ010000012.1  52139848-52140050   c
            2019-2156           JAXUCZ010000012.1  52139109-52139246   c
            2157-2318           JAXUCZ010000012.1  52136241-52136402   c
            2319-2687           JAXUCZ010000012.1  52135506-52135874   c
            2688-2765           JAXUCZ010000012.1  52133802-52133879   c
            2766-3029           JAXUCZ010000012.1  52132623-52132886   c
            3030-3124           JAXUCZ010000012.1  52131526-52131620   c
            3125-3341           JAXUCZ010000012.1  52129845-52130061   c
            3342-3485           JAXUCZ010000012.1  52128948-52129091   c
            3486-3683           JAXUCZ010000012.1  52127867-52128064   c
            3684-3800           JAXUCZ010000012.1  52125433-52125549   c
            3801-3940           JAXUCZ010000012.1  52120961-52121100   c
            3941-4073           JAXUCZ010000012.1  52120173-52120305   c
            4074-4196           JAXUCZ010000012.1  52119896-52120018   c
            4197-4358           JAXUCZ010000012.1  52117567-52117728   c
            4359-4522           JAXUCZ010000012.1  52116696-52116859   c
            4523-8008           JAXUCZ010000012.1  52112129-52115614   c
FEATURES             Location/Qualifiers
     source          1..8008
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..8008
                     /gene="Golga3"
                     /note="golgin A3"
                     /db_xref="GeneID:312077"
                     /db_xref="RGD:1305262"
     exon            1..47
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            48..366
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="Golga3"
                     /note="upstream in-frame stop codon"
     CDS             231..4694
                     /gene="Golga3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Golgin subfamily A member 3; golgi autoantigen, golgin
                     subfamily a, 3"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 1"
                     /protein_id="NP_001424400.1"
                     /db_xref="GeneID:312077"
                     /db_xref="RGD:1305262"
                     /translation="MDGASAKQDGLWENKSSSDISSCPEASLETVGSLAQLPDQQDTA
                     QDGSVEVNRVFKEEGSPDRSSQVPICQNGQIPDLQLSLDPTTSPVGPDASTGVDGFHD
                     NLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEE
                     QLMQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPRASAVAVTKEYSFLRTSVP
                     RGPKVGSLGLLAHSKEKKNSKSSKIRSLADYRTEDPSDSGGLGSTADAVGSSLKQSRS
                     STSVVSEVSPSCETDNRAESASLAGDSVSEADGNESDSSSHSSFSARGACAVLGNVGT
                     PGAAYVVDGQEISAEALGQFPSIKDVLQAAAAQHQDQNQEANGEVQSRRDSICSSVSM
                     ESSFAEPQEELLQILKDKRRLEGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVE
                     HSHSSQQKQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQY
                     QRLMAKVEAMQRNILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLQASQAEITS
                     LQQARQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQ
                     HRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEEDLQRKLEEFEGEREQLQK
                     VADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQLTSTQEALQAKGQSLDDLQ
                     TRYDELQARLEELQREADSREDAIHFLQNEKIVLEVALHSARSDKEELDRGARRLEED
                     TEETSGLLEQLRQDVAVKSNQVEHLQQETATLRKQMQKVKEQFLQQKVMVEAYRRDAA
                     SKDQLINELKATKKRLDSEMKELRQELIKLHGEKKTVEVEHSRLQKDMSLVHQQMAEL
                     EGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLKKQIEELQQEAKKAITEQKQ
                     KMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALANKEATDAELNQLRAQSTGG
                     SSDPALHEKIHALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLELEDELQE
                     SRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLV
                     QLNLQVQAVLQRKEEEDRQMKQLVQALQISLEKEKTEVSSLKEQMAAARVEAGHNRRH
                     FKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQEGKHSQEIAQFQTELAEARTQLQ
                     LLQKKLEEQRSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEHQGKKELEGTQQT
                     LQTIKSELETVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKKK
                     EPKGESSSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDS
                     LQRQMEEHTITVHESLSSWAQVEAAPAEHAHARGDTKVHNQNSVPGEGLGQ"
     misc_feature    <1242..3188
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1242..3188
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2217..4283
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2217..4283
                     /gene="Golga3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            367..636
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..749
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1396
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1508
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1815
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2018
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2156
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2318
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2687
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2765
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..3029
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3124
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3341
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3485
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3683
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3800
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3940
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4073
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4196
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4358
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4359..4522
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..8008
                     /gene="Golga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcacggc cacgtcctac cggagccgca gggttgggcc gctacgggaa tcatggtatt
       61 gcttggtttg acttcaagcc atttatgaga ctttaaacct taccctgaaa atggaaaaca
      121 gagtaagatc cttcttagaa gctctgagct gttgctgatg gcaaaaagca aacttaatcc
      181 agagttacct gtagctcctc agagtcttct tagtctgggc tgccctgacc atggatggag
      241 catcagccaa acaggatggc ctctgggaaa acaagtctag cagtgatatt tcatcttgcc
      301 ctgaagcctc actggaaact gtgggctctt tggcccaact gcctgaccaa caagatacag
      361 ctcaggatgg cagtgttgag gtaaacagag tttttaagga agaaggaagc ccagacagat
      421 ccagccaggt gcccatctgt cagaatgggc agatcccaga ccttcagttg tctcttgatc
      481 ccacaacaag cccagtggga cctgatgcct ctacaggtgt ggatggtttc catgacaacc
      541 taaggaagtc tcagggaact agtgctgagg gcagtgttag aaaagaagct ttgcagtctc
      601 tcagactcag tcttcccatg caagaaacgc aactgtgctc tactgcatct tcactgccct
      661 tggaaaagga ggagcaggtc cgactgcagg cccggaagcg cctggaagag cagctgatgc
      721 aataccgagt taagcgccat cgggaaaggt ccagtcagcc ggcaactaaa atgaaacttt
      781 ttagtacact tgatcctgag ctcatgttaa atccagaaaa cttgccaagg gccagtgctg
      841 tagctgtgac aaaagaatat tccttcctgc gtaccagtgt tcctcggggg cccaaggtag
      901 gcagcttagg gctgctggca cattctaaag agaagaagaa ttccaagtca agcaagattc
      961 ggtctctggc tgactataga actgaagatc caagtgactc tggtggcctt ggttctactg
     1021 ctgatgctgt tggaagttcc ctgaaacaga gtagaagtag cacttcagtt gtgtctgaag
     1081 tgagcccatc atgtgagact gataaccgtg cagagagtgc ctcactggct ggggacagtg
     1141 tgtcagaggc tgatggaaat gagagtgaca gttcctcaca cagcagcttc tctgcccgag
     1201 gggcctgtgc tgtcctgggg aatgtcggca caccaggagc agcttacgtg gttgatggcc
     1261 aggagatttc tgctgaggcc ctgggccagt ttccttcgat taaagacgtg ctacaggctg
     1321 cagcagccca gcaccaagat cagaaccagg aagccaatgg ggaggtgcag agccgcagag
     1381 acagcatctg cagcagtgtg tccatggaga gctcttttgc tgaaccacag gaagaattgt
     1441 tgcagatcct taaagataag aggagacttg aaggacaggt ggaggctttg tcattagaag
     1501 ccagtcaggc acttcaagag aaggctgagc tacaggccca gcttgctgcc ctgagcacaa
     1561 ggctacaggc acaggtggaa cacagtcaca gcagccagca gaagcaagac tcccttagtt
     1621 ctgaagtgga cactttgaag cagtcttgct gggatttgga gcgggctatg actgacctgc
     1681 agaacatgct agaagctaaa aatgccagcc tggcatcgtc aaacaatgac ctacaagtgg
     1741 cagaggagca gtatcagaga ctgatggcca aagtggaggc catgcagaga aacatcctta
     1801 gcaaggacaa cacagttcat gacctgcggc agcagatgac agcgctacag agccagctcc
     1861 agcaagtaca gctggagcgc acaacactga ccagcaaact acaagcatca caggctgaaa
     1921 tcacttcttt gcagcaggcc cggcagtggt accaacagca gcttgctttg gcccaggagg
     1981 ccagagtcag gctgcaagga gagatggccc acatccaggt cggacagatg actcaagcgg
     2041 gccttttgga gcacctgaaa cttgagaatg tgtccctatc gcatcagcta acagaaactc
     2101 agcacagatc catcaaggaa aaagagcgca tagctgttca gctccagagc attgaggctg
     2161 acatgttaga tcaggaggca gcatttgtac agattcggga ggcgaagaca atggtggaag
     2221 aagacctcca aaggaagctg gaagaatttg aaggtgaacg ggaacagtta cagaaagtgg
     2281 cggatgcagc agcgtccctg gagcaacagt tggaacaggt gaagttgaca ttgttccagc
     2341 gagatcagca gctggcagca cttcagcagg agcatctaga tgtgataaag cagcttacat
     2401 cgacacagga ggctctacag gccaaagggc agtccctcga tgacctgcaa acacgttatg
     2461 atgagctaca agcaaggctg gaagagctgc agagagaggc tgactccagg gaggatgcca
     2521 ttcacttctt gcagaatgag aagattgtct tagaagtggc tctgcactca gccaggagtg
     2581 acaaggagga acttgacaga ggagcacggc gtttggaaga agatactgag gagacatcag
     2641 gacttttaga acaattgaga caagatgtgg ctgtcaagtc caaccaggtg gaacacttgc
     2701 agcaagagac agccacattg agaaaacaga tgcagaaagt aaaggagcag tttcttcagc
     2761 aaaaggtgat ggtagaggcc tatcggcgag atgctgcttc taaagaccaa ctcatcaatg
     2821 agctgaaagc taccaaaaaa cgcctggact cagagatgaa ggaactgagg caggagctga
     2881 tcaagctgca tggagagaag aagactgtgg aagtagagca ctcacggctg cagaaggaca
     2941 tgtccctggt tcaccagcag atggcagagc ttgaggggca tctccagtcg gtgcagaaag
     3001 agcgagatga aatggagatt cacctgcagt ctttgaagtt tgacaaagag cagatgatag
     3061 cccttactga ggccaatgag acactaaaga aacaaataga ggagctgcag caagaggcca
     3121 agaaggccat cacagaacag aagcagaaga tgaagcggct gggctcagat ctgaccagtg
     3181 cccagaagga gatgaagact aagcacaagg cttacgagaa tgctgtgagc attctcagcc
     3241 gtcgcctaca ggaggctctg gctaacaagg aggccacaga tgcggagctg aaccagctca
     3301 gagctcagag cacaggtggc agcagtgacc ctgctctaca tgagaagatt catgctctgg
     3361 aggtggaact gcagaatgtt ggccaaagca aaatactgct ggagaaggag ttacaggagg
     3421 tgatcacgat gactagccag gagttggaag agtcccggga gaaggtgctg gagctcgagg
     3481 atgagcttca agaatccaga ggcttcagaa ggaagataaa acgtcttgaa gagtcaaata
     3541 agaagctagc tctggagtta gaacatgagc gagggaagct caccggcctt ggacaatcta
     3601 atgcggcttt gcgggagcac aacagcattc tggaaactgc actagccaag agggaagctg
     3661 acctggtgca gctgaatctc caggtgcagg cagttttaca gcgcaaagag gaggaggatc
     3721 gccagatgaa gcaacttgtc caagccttac aaatctcatt agagaaagaa aagacggaag
     3781 tgagcagcct gaaggaacag atggctgctg ccagggtaga agctgggcac aaccgccgcc
     3841 actttaaggc agcgactttg gagctgagtg aggtgaagaa agaattgcag gccaaagaac
     3901 acctggtaca gacactgcag gccgaggtgg atgagctcca gattcaggag ggaaagcatt
     3961 ctcaagaaat cgctcaattc cagactgagc tggcagaagc taggacccag ctccagctcc
     4021 tgcagaagaa gctcgaagaa cagaggagcc agcaaccaac agggagccaa gagatggaag
     4081 atctcaaatg ggaattggat cagaaagaac gagagattca gtccctgaag cagcagcttg
     4141 acttgacaga gcaccagggc aagaaagaac tcgagggtac acaacagaca ctgcagacta
     4201 tcaagtctga gttggaaacg gttcaggaag atctgtctga gacccagaag gataagttta
     4261 tgcttcaagc caaagtgtct gaactgaaga acaacatgaa gactctgctg cagcagaacc
     4321 aacagctcaa gctggatctc cgccgcggtg cagccaagaa gaaagagcca aaaggtgagt
     4381 ccagctcatc cagtccagca acacccatca agataccaga ctgccctgtc ccagcctcac
     4441 tgctggagga gctgctgagg cccccacccg ctgtgagcaa ggagcccctg aagaatctca
     4501 acagctgttt gcagcagctc aagcaggaaa tggacagtct acagcgccag atggaggagc
     4561 ataccatcac tgtgcatgag tccctgtcct cgtgggctca ggtggaagct gccccagcag
     4621 agcatgccca tgcccgggga gacacaaaag tacacaatca aaacagtgtt cctggagaag
     4681 ggctgggcca atgaccactg ttgtccttat caccaagtat ttgtggctgt tgaaggaata
     4741 ctcttgtcaa tattatttat ttgattgaat gctctggtgg ctttcttttt ttttcgtttt
     4801 ttaagaaatt acttaaattt cccttcactt tttatcaagg attaaaataa caaacatctg
     4861 ggaggtggtg gcacacactt ttaatcccag cacccaggag gcagatgtag gcatgatctc
     4921 tatgagtttg aggccagcct ggtctacaga tcaatagttc cagaacagcc agggctacaa
     4981 agagagactc ttgtctcaaa ataaataaat aaagggatga ggcaagaatt aaaaacatag
     5041 tcatagcttt tcccatgaaa tgaccaattc ttaaaaacat cagagtttgg actgctggtg
     5101 aaatctgagt gtgtatatct gaacagtcac ttgcagaagg agagaacttc atgtgtggct
     5161 acagacacac ataagacctt tactttccta cataaatgag tttttattta caccttttgc
     5221 tttttatttc atttgccttt caaactattc tacctaaata ggatgtatat atataaatac
     5281 caaaagtctt ttgaaaacat acacctatgt tatttaagga tctaattgtt ttactactga
     5341 tttccctttg aaaatttgct actgggaaac agtatacatg tagctttagg ggtgtcagtt
     5401 taaaaatgta ttttaagaag tataacttat tttctatgca tcctaaaacc aaatactctt
     5461 ggcacagaaa gaattgtgtt agttttagtc ttttcatttc tgagggtctt ttctaccaac
     5521 atgtccatga attaataaca ctgacctttt aggtctgtgg ccttacgtgg ttttactcac
     5581 tttggcttac caacaggcag ggccagtcag gccttgaggt cagttagcag gggacaaaag
     5641 gacctccaag gtctcctcat actgacctga tatttggaga acactggtgg aggcagcctt
     5701 gggctgtggg ttataggctg caaacactgt gtcccaaaga tggtgtttat gaaacagtga
     5761 atgtctgtct gtgggcatca ggaaccacca tggacctcta ttgaatactt gtggcacaac
     5821 aagccagagt aatacctgga agaaggtagg caactttggt tttctgagac agggttaaaa
     5881 gacaaaagcc ttgtttaaag tcagcaccaa gtgtgtgatt tattgctgtc tgcttcccaa
     5941 atcataataa tatttacata gaacacctga cttgaggtct gtaatctttg tgaatgcttg
     6001 tgaagaaaat ttaaaataaa gtagattttt gatccatgac tgtaacccca gcacttggga
     6061 gatagaatca ggaggcgaat ctgttcaaga ctagttttca gctacacagc aagtttgagg
     6121 caagactggg ttacatgaac catgacttag aaagacagac aagctggaac aacaagagaa
     6181 acgatctgga acagtgttag aaggaaaagg gagaaagacc tgaaggaagc tgtaagcgtg
     6241 ttcagctagt tggtgtcttt gagtgggttt cttgtctatt ttatggaaaa tcagtatggc
     6301 atttttaatc tgtgttctct taaaatatcc tattagagcg gtaaatgatg tggttaaagt
     6361 agaattatca gcagtgatgt ctggtgtttg aaaaatattc tttagcaagt attgggactt
     6421 taaagtgtgt atatcacttg tacagggtta atcttaaaaa aatctttaaa acgttattgt
     6481 aaatataccc ttttattctc taagatagaa attagaaaaa gatggtaatt tacattattt
     6541 attttgtatt tttaatgtca aaaccaagaa atagctcttg gtttggactt actctgcaac
     6601 agagctagtt tctcctatgt aaagagatct tcaagtgagt tttgttgatt gtgttgtctg
     6661 gggaaggata agctaattct gaactcattc agatgaaggt tgttttcatg tcttaaccca
     6721 tttcttcggt tgctttgctg tcccatatgc acgtcccata tgtccctcag aaatgtcact
     6781 tcttctaaac tttgtagtct gccttgtgaa tccttggcta ggttcctttt ggttccatga
     6841 aaggtctgac atgtcttggc ttctttctct gtccctcttt gcatgtcaat gtgtcttttc
     6901 tcacagttgt gattcagagg actcttagat tggagccggg attctcttag ggctctttaa
     6961 gtcacattga agttgagttt tcaggttccc tttttttgtt tgtttgtttt gagtttttcc
     7021 cttctatttt tccctcttat ttctattgta cttcgcctcc ttgagcttat tcctgagtga
     7081 atatggcttg actactgttg cctctgcagc cagacctggg ggttttagtt tgctcatgaa
     7141 aaagtgcagg caggtatgga gaattgcttt ctcaggcggg ctcacaccat tgtgtaccat
     7201 ttctgcatat atcatatatg ctgaatcttg tcctatactg gacaccttgg cttgcatgct
     7261 ttatactatt agttttctta tgtttaaaaa ttaccatgaa atttctatct ttgtttctat
     7321 ggtagacgtc caattgatgc tgtgatttta gatttttata ccatggtagc aggcaatgat
     7381 tttgagagat gtgaggctga ctttacgtgg acgtgggata cagggagctc agaaggtaga
     7441 cttagtgcat atatcaaaaa gcttggttaa attcttctcc atttcaaaat aaactttcca
     7501 gtatgtggac actgtaaaag ccataggctt ataggtcaca atgatatata tttttcatat
     7561 attttgaaac aaaaattggc aggtgaagat tctggattta aaagggacca tcatatttga
     7621 aaagtcctgg aacctcagag gacccctgtg ataaaaataa tactgtggca tgagatatct
     7681 cgagtcttaa tctaacatgc tcagtagttt ggaaatctag cccagtctac tctgtagtgg
     7741 tcataggttc tgacaggatc tttgggtcca tgtacggttt ggagggtcca acatttcagt
     7801 gctttttgag tttctcattt ctataaaaag ttatcttaca agggagtcag tcttcatgtt
     7861 ggggctttcc cagggaaact gtcatcactg gtaacaaact gtaactttaa aaaggcatgt
     7921 tgttgctgtt attgttttgc cttctttttt taatataagt gtgcttggga actccttaca
     7981 ttttatgcaa taaactattt ttggtaaa
//
LOCUS       NM_001437243             105 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus HR upstream open reading frame (Hrurf), mRNA.
ACCESSION   NM_001437243
VERSION     NM_001437243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000015.1  52039162-52039266
FEATURES             Location/Qualifiers
     source          1..105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15"
     gene            1..105
                     /gene="Hrurf"
                     /note="HR upstream open reading frame"
                     /db_xref="GeneID:134482144"
                     /db_xref="RGD:402444115"
     CDS             1..105
                     /gene="Hrurf"
                     /note="protein HRURF"
                     /codon_start=1
                     /product="HR upstream open reading frame"
                     /protein_id="NP_001424172.1"
                     /db_xref="GeneID:134482144"
                     /db_xref="RGD:402444115"
                     /translation="MAQPTASAQKLVRPIRAVCRILQIPESDPSNLRP"
     exon            1..105
                     /gene="Hrurf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgcaac ctacagcctc ggcccagaag ctggtgcggc ccatccgcgc cgtgtgccgc
       61 atcctgcaaa tcccggagtc cgacccctcc aacctgcggc cctag
//
LOCUS       NM_001437500            6980 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 1 (Tjp1), transcript
            variant 8, mRNA.
ACCESSION   NM_001437500 XM_039105296
VERSION     NM_001437500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6980)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6980)
  AUTHORS   Lou,X., Mou,Q., Zhao,B., Huang,J., Yao,K., Luo,Z., Ye,M., Hu,Y.,
            Duan,Q., Li,X., Wen,Z., Chen,Z., Zhang,H. and Zhao,Y.
  TITLE     VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via
            Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
  JOURNAL   Oxid Med Cell Longev 2021, 9397960 (2021)
   PUBMED   34552687
  REMARK    GeneRIF: VIP Stabilizes the Cytoskeleton of Schlemm's Canal
            Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal
            Degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6980)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6980)
  AUTHORS   Hou,Q., Huang,Y., Wang,Y., Liao,L., Zhu,Z., Zhang,W., Liu,Y.,
            Li,P., Chen,X. and Liu,F.
  TITLE     Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1
  JOURNAL   J Microbiol Biotechnol 30 (10), 1480-1487 (2020)
   PUBMED   32807750
  REMARK    GeneRIF: Lactobacillus casei LC01 Regulates Intestinal Epithelial
            Permeability through miR-144 Targeting of OCLN and ZO1.
REFERENCE   5  (bases 1 to 6980)
  AUTHORS   Ribeiro Hudson,A.S., Nascimento Soares,A.D., Coelho Horta,N.A.,
            Fuscaldi,L.L., Machado-Moreira,C.A., Soares,D.D., Coimbra,C.C., de
            Oliveira Poletini,M., Cardoso,V.N. and Wanner,S.P.
  TITLE     The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats
  JOURNAL   J Therm Biol 91, 102610 (2020)
   PUBMED   32716860
  REMARK    GeneRIF: The magnitude of physical exercise-induced hyperthermia is
            associated with changes in the intestinal permeability and
            expression of tight junction genes in rats.
REFERENCE   6  (bases 1 to 6980)
  AUTHORS   Kawajiri,A., Itoh,N., Fukata,M., Nakagawa,M., Yamaga,M.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of a novel beta-catenin-interacting protein
  JOURNAL   Biochem Biophys Res Commun 273 (2), 712-717 (2000)
   PUBMED   10873669
REFERENCE   7  (bases 1 to 6980)
  AUTHORS   Kidson,S.H., Kume,T., Deng,K., Winfrey,V. and Hogan,B.L.
  TITLE     The forkhead/winged-helix gene, Mf1, is necessary for the normal
            development of the cornea and formation of the anterior chamber in
            the mouse eye
  JOURNAL   Dev Biol 211 (2), 306-322 (1999)
   PUBMED   10395790
REFERENCE   8  (bases 1 to 6980)
  AUTHORS   Toyofuku,T., Yabuki,M., Otsu,K., Kuzuya,T., Hori,M. and Tada,M.
  TITLE     Direct association of the gap junction protein connexin-43 with
            ZO-1 in cardiac myocytes
  JOURNAL   J Biol Chem 273 (21), 12725-12731 (1998)
   PUBMED   9582296
REFERENCE   9  (bases 1 to 6980)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
REFERENCE   10 (bases 1 to 6980)
  AUTHORS   Rajasekaran,A.K., Hojo,M., Huima,T. and Rodriguez-Boulan,E.
  TITLE     Catenins and zonula occludens-1 form a complex during early stages
            in the assembly of tight junctions
  JOURNAL   J Cell Biol 132 (3), 451-463 (1996)
   PUBMED   8636221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039105296.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000001.1  128504787-128505023 c
            238-370             JAXUCZ010000001.1  128488840-128488972 c
            371-427             JAXUCZ010000001.1  128325302-128325358 c
            428-552             JAXUCZ010000001.1  128309353-128309477 c
            553-655             JAXUCZ010000001.1  128308404-128308506 c
            656-932             JAXUCZ010000001.1  128306471-128306747 c
            933-1036            JAXUCZ010000001.1  128303218-128303321 c
            1037-1205           JAXUCZ010000001.1  128302666-128302834 c
            1206-1353           JAXUCZ010000001.1  128302203-128302350 c
            1354-1493           JAXUCZ010000001.1  128295152-128295291 c
            1494-1599           JAXUCZ010000001.1  128294447-128294552 c
            1600-1750           JAXUCZ010000001.1  128291713-128291863 c
            1751-1859           JAXUCZ010000001.1  128289070-128289178 c
            1860-2079           JAXUCZ010000001.1  128287751-128287970 c
            2080-2264           JAXUCZ010000001.1  128287297-128287481 c
            2265-2360           JAXUCZ010000001.1  128287089-128287184 c
            2361-2443           JAXUCZ010000001.1  128284354-128284436 c
            2444-2654           JAXUCZ010000001.1  128283655-128283865 c
            2655-2755           JAXUCZ010000001.1  128283262-128283362 c
            2756-3106           JAXUCZ010000001.1  128280040-128280390 c
            3107-3346           JAXUCZ010000001.1  128279474-128279713 c
            3347-4216           JAXUCZ010000001.1  128277918-128278787 c
            4217-4314           JAXUCZ010000001.1  128277712-128277809 c
            4315-4542           JAXUCZ010000001.1  128276273-128276500 c
            4543-4709           JAXUCZ010000001.1  128271583-128271749 c
            4710-5184           JAXUCZ010000001.1  128266965-128267439 c
            5185-5402           JAXUCZ010000001.1  128265159-128265376 c
            5403-5486           JAXUCZ010000001.1  128263837-128263920 c
            5487-6980           JAXUCZ010000001.1  128260332-128261825 c
FEATURES             Location/Qualifiers
     source          1..6980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6980
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
     exon            1..237
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    59..61
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="upstream in-frame stop codon"
     CDS             65..5581
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="isoform 8 is encoded by transcript variant 8; zona
                     occludens 1; tight junction protein ZO-1; zona occludens
                     protein 1; zonula occludens protein 1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform 8"
                     /protein_id="NP_001424429.1"
                     /db_xref="GeneID:292994"
                     /db_xref="RGD:1306305"
                     /translation="MRRLEGLCLRRRRRRRGPARERSGDKMKYQKYLTVLQMAIGVTP
                     SNRGSLLPLKRKLWVTPSSENPHGATSNVSQGKPSLRRIKGRLHRSKSLDSIDFCELT
                     STAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEG
                     QLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPDPVS
                     DNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAK
                     PTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS
                     LTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDH
                     SVRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVK
                     HVDDHTPKAVEEVTVEKHEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHED
                     GILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNV
                     DFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKES
                     PYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYT
                     LPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPV
                     TIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHAL
                     LDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRK
                     NNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLS
                     YLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSE
                     PVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKTASQQKAEASSPVPYLSPETN
                     PASSASAVKHNVNLTNVNLEEPTPAPPTSHVSQADCLGAPSPEAPHTMLRDEGVSLPS
                     HVDPAKVYRKEPYPEEMMRQNHILKQPALGHPGQRLDKEPNPAYDPQLPYVEKQASRD
                     LEQPPYRYESSSYTDQFSRNYDHRLRFEDRVPTYEDQWSYYDDKQPYPTRPFDTQHPR
                     DLDSRQHPEEASERGYFQRFEEPAPLPYDSRPRYEQLPRTSTLRHEEQPTSGYEVHNR
                     YRPEAQPYAPAGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIP
                     SSQHKPEVLPSATKPQPPPPALTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVN
                     DTASFKPPEVASKPPSASLVGPKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRSN
                     HYDPEEDEEYYRKQLSYFDRRSFESKPPAHIPAGHHSEPAKPVHSQSQPNFSSYSSKG
                     KPETDAMDRSFSEKRYDPTQAMPPPPPLPSQYSQPVPPLSNSSLHIHSKAAQSEGNSV
                     SLDFQNSYISKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKASVNGAEQTQKTI
                     TPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAH
                     SSTQPPEFDSGVETFSVHTDKPKYQINNISTMPKAVPVSPSAVEEDEDEDGHTVVATA
                     RGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLL
                     SPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF"
     misc_feature    407..667
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    407..667
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(440..460,512..514,521..523,605..607,617..619,
                     626..631)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(440..460,512..514,521..523,605..607,617..619,
                     626..631)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    899..1132
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    899..1132
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(899..916,929..979,986..994,1001..1003,1007..1012,
                     1031..1033,1055..1060,1064..1069,1103..1123)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(899..916,929..979,986..994,1001..1003,1007..1012,
                     1031..1033,1055..1060,1064..1069,1103..1123)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(932..952,968..970,977..979,1067..1069,1079..1081,
                     1088..1093)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(932..952,968..970,977..979,1067..1069,1079..1081,
                     1088..1093)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1607..1846
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1607..1846
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1637..1657,1685..1687,1694..1696,1781..1783,
                     1793..1795,1802..1807)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1637..1657,1685..1687,1694..1696,1781..1783,
                     1793..1795,1802..1807)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1892..2086
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    1892..2086
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; Region: SH3_ZO-1;
                     cd12026"
                     /db_xref="CDD:212959"
     misc_feature    order(1892..1900,1982..1990,2003..2005,2012..2014,
                     2069..2071)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1892..1900,1982..1990,2003..2005,2012..2014,
                     2069..2071)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="PDZ interface; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1898..1918,1955..1960,1967..1969,2012..2014,
                     2036..2041,2063..2071,2081..2086)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1898..1918,1955..1960,1967..1969,2012..2014,
                     2036..2041,2063..2071,2081..2086)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="GuK interface [polypeptide binding]; other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1916..1918,1922..1924,1931..1933,1943..1945,
                     2006..2011,2066..2068,2072..2077)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    order(1916..1918,1922..1924,1931..1933,1943..1945,
                     2006..2011,2066..2068,2072..2077)
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212959"
     misc_feature    2186..2725
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    2186..2725
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    <3218..5041
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3218..5041
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    5228..5548
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     misc_feature    5228..5548
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; Region: ZU5; smart00218"
                     /db_xref="CDD:128514"
     exon            238..370
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..427
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..552
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..655
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..932
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1036
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1205
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1353
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1493
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1599
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1750
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1859
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2079
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2264
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2360
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2443
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2654
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2755
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..3106
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3346
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..4216
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4314
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4542
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4709
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..5184
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5402
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5403..5486
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..6980
                     /gene="Tjp1"
                     /gene_synonym="ZO-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcacggcg gcaggagctg gagcggggcg cgcggtgggg cggcggatgg cccagagctg
       61 atctatgcgg cgcttggagg ggctgtgtct gcggcggcgg cggcggcggc ggggccctgc
      121 ccgggagcgg agcggggaca agatgaagta ccagaaatac ctgacggtgc tgcagatggc
      181 catcggcgtc accccgtcca accgcggcag cctcctgccg ctcaagagga agctgtgggt
      241 aactccatcc tctgaaaacc cccatggtgc tacttccaat gtcagccaag ggaaaccttc
      301 tctaagacga attaaaggga gactacatcg aagcaaaagc cttgacagta tcgacttctg
      361 tgagctcact agcacagcaa tggaggaaac agctatatgg gaacagcaca cagtgacgct
      421 tcacagggct cctgggtttg gatttggaat tgcaatatct ggtggaagag ataatcctca
      481 ttttcagagt ggggaaacct ccatagtgat ttctgatgtg ctaaaaggag ggccagctga
      541 aggacagcta caggaaaatg accgagtcgc aatggttaac ggagtttcaa tggataatgt
      601 tgaacatgct tttgctgttc agcagctaag gaaaagtggg aaaaacgcaa aaattaccat
      661 ccgaagaaag aagaaagttc agattcctgt aagtcaccca gaccctgacc cagtgtctga
      721 taatgaagat gatagctatg acgaggatgt gcacgatcca agaagtggcc gaggtgccct
      781 agctaacaga aggggtgaga agagctgggc aagggataga agcgcaagca gggaccggag
      841 cctgtcccct cgctcagaca ggcgatcagt ggcctccagt cagcccgcca aacccaccaa
      901 ggtcacattg gtgaagtctc ggaaaaatga agaatatggt cttcgattgg ccagccatat
      961 atttgtaaag gaaatttcac aagatagttt ggcagcaaga gatggtaaca ttcaagaagg
     1021 ggatgttgtc ctgaagataa atggtactgt gacagaaaat atgtcactga cagatgcaaa
     1081 aacattgata gaaaggtcta aaggcaagtt aaaaatggta gtgcaaagag atgagcgggc
     1141 taccttattg aatgtccctg atctttcaga tagtatccat tctgctaatg cctctgaaag
     1201 agatgacatt tcagaaattc agtcactagc atcagaccat tcagttcgct cccatgacag
     1261 gcctccccgc cgaagccagt cacgatctcc cgaccaacgt tcagagccct ctgatcattc
     1321 cacacagtct ccacagcagc ccagcaatgg cagtctccgg agcagagagg aagagcgcat
     1381 gtctaaaccc ggggctgtct caactcctgt aaaacatgta gatgatcata cacccaaagc
     1441 agtggaagaa gttacagttg aaaaacatga gaagcagaca cccactcttc cagaaccaaa
     1501 acctgtatat gctcaagtcg gacagccaga tgtggattta cctgtcagcc cttctgatgg
     1561 tgttctgcca aattcaacac atgaagatgg gattcttagg cccagcatga aactggtaaa
     1621 attcagaaaa ggagatagtg tgggtttgcg actagctggt ggaaatgatg tcggaatatt
     1681 tgtagctggc gttctagaag atagccctgc agccaaagaa ggcttagagg aaggtgatca
     1741 aattctcagg gtgaacaatg tagatttcac aaatatcata agagaagaag ctgttctttt
     1801 cctcctcgac ctccctaaag gtgaagaagt gaccatattg gctcagaaga aaaaggacgt
     1861 ttatcgccgc attgtagagt cagatgtagg agactcgttc tatattagaa cacattttga
     1921 atatgagaaa gaatctcctt atggactcag ttttaacaaa ggagaggtgt tccgggtcgt
     1981 ggacaccctg tacaacggga agctgggctc ctggctggcc attcgaattg gcaaaaatca
     2041 caaggaggta gagcgaggca tcgttcctaa taagaacaga gccgagcagt tagccagtgt
     2101 acagtacaca cttccaaaga cagcaggtgg cgatcgggca gacttctgga ggtttcgagg
     2161 tcttcgtagc tccaagagaa atcttcgaaa aagcagagag gacctgtcag cgcagccagt
     2221 tcaaacaaag ttcccagctt atgaaagggt tgttcttcga gaagctggat tcctaagacc
     2281 tgtaaccatc tttggaccga ttgctgatgt tgccagagaa aagttagcaa gggaggagcc
     2341 agacatttat cagattgcaa aaagtgaacc acgagatgct ggaactgacc atcggagctc
     2401 gggcattatt cgccttcata caataaagca aatcatagat caagataaac atgctttatt
     2461 agatgtcaca ccaaatgcag tcgatcgcct taattatgca cagtggtatc cgattgttgt
     2521 gttccttaac cctgactcta agcagggtgt aaaaacaatg aggatgaggc tatgtccaga
     2581 gtctcggaaa agtgccagga agctatatga acggtctcat aaacttcgta aaaataatca
     2641 ccatcttttt acaaccacaa ttaacttaaa ctcaatgaat gatggttggt atggtgccct
     2701 gaaagaagcg attcagcagc aacagaacca gctggtgtgg gtctctgagg ggaaggcgga
     2761 tggtgctaca agtgatgacc ttgatttgca tgatgatcgt ctgtcctacc tgtcagcccc
     2821 aggtagtgag tactcaatgt atagcacgga cagtagacac acttctgact atgaagacac
     2881 agatacagaa ggcggggcct acactgatca agaactagat gaaactctta atgatgaggt
     2941 ggggactcca ccggagtctg ctattacacg gtcctctgag cctgtaagag aggattcctc
     3001 tggaatgcat catgaaaacc aaacatatcc tccttactca ccacaagcgc agccacaagc
     3061 tattcataga atagactccc ctggacttaa gacagcctct caacagaaag cagaagcctc
     3121 atctccagtc ccttaccttt cgcctgaaac aaacccagca tcatcagcct ctgcagttaa
     3181 gcataatgta aatttaacta atgtcaacct ggaggagccc accccagctc ctcccacctc
     3241 gcacgtatca caagctgatt gtttaggagc accaagtcct gaggcacctc acacgatgct
     3301 cagagacgaa ggagtgtcat tgccgtcgca tgtagaccca gcaaaggtat ataggaagga
     3361 gccatatcct gaggaaatga tgagacaaaa ccatatttta aaacagccag ctcttggtca
     3421 tccagggcag aggctggata aagagccaaa tccagcctat gatccccaac ttccatatgt
     3481 agaaaaacaa gccagcagag accttgagca gccaccatac aggtatgagt cctcaagcta
     3541 cacagaccag ttttctcgga actatgacca tcgcctacga tttgaagacc gagtccctac
     3601 ctatgaagac cagtggtcat attatgatga caaacagccc tacccaactc ggccctttga
     3661 tactcagcat cctcgagact tggactccag acagcatcct gaagaggctt cagaacgagg
     3721 ctatttccag cgttttgaag agcccgcccc tctgccatat gacagtagac cacgctacga
     3781 gcagctgcct cgaacctcta ctctccgaca tgaagaacag ccaaccagtg gatatgaggt
     3841 gcacaacagg tacaggccag aagcacagcc ctatgctcca gcaggtccta agtcatctga
     3901 gccgaagcag tactttgacc agtacccacg aagttatgag caagtaccac caccaggatt
     3961 tacctccaaa acaggccatt acgagcctct ccatggtgct gcagttgttc ctcctctgat
     4021 accttcctct caacataagc cagaagttct gccctcagct accaagccac agcctccgcc
     4081 cccagcccta actgaggaag aggaggatcc agcaatgaaa ccacagtctg tgctcaccag
     4141 ggtcaaaatg tttgaaaaca aaagatctgc gtctctggag aacaagaagg atgtgaatga
     4201 cactgccagc tttaagcctc cagaagtagc atctaaacct ccaagtgctt ctcttgttgg
     4261 ccctaaacct gtttctcaga ctcagtttag tgagcatgac aaaacactct acaggctccc
     4321 agagcctcag aaacctcaag cgaagccacc tgaagatatt gttcgatcaa atcattacga
     4381 tcctgaagag gatgaagagt attaccggaa acagctctct tactttgacc ggagaagttt
     4441 cgagagcaag cctcctgcac atattcctgc tggccatcac tcagagcctg ccaagccagt
     4501 ccattctcag agtcagccga atttctctag ttattcttca aaggggaaac ccgaaactga
     4561 tgctatggat agatcattca gtgagaaacg ttatgatcca acccaggcca tgcctcctcc
     4621 tcctccgttg ccctcacagt acagccagcc agttccgcct ctgtccaact cttctctcca
     4681 catacattcc aaggccgccc agagtgaagg caattccgta tcgttggatt ttcagaactc
     4741 atatatatcc aaaccagacc cacccccatc tcagagcaaa ccagcaactt ttagaccacc
     4801 aacccgggag gaccctcctc agaccttcta tccccagaaa agtttcccag acaaagcttc
     4861 agttaatgga gctgagcaga ctcagaaaac catcactcca gcatacaacc gattcacacc
     4921 aaagccgtac acgagctctg cccggccatt tgaacgcaag tttgaaagtc caaagttcaa
     4981 ccataatctt ctgccaagtg aaactgtaca taaacctgaa ttgtcttcaa aacctccccc
     5041 ttctccaaaa actctcatga aggctcatag ttccacacag ccgcctgagt ttgacagtgg
     5101 agtcgagact ttctctgttc acacagataa gcctaaatat caaataaata atatcagcac
     5161 catgcctaaa gctgttcctg tgagtccttc agctgtggaa gaagatgaag atgaggatgg
     5221 tcatactgta gtggctacag cccgcggcat ttttaacagc aatggcggtg tgttgagttc
     5281 catagaaact ggtgttagta taattatccc acaaggagcc attcctgaag gaattgagca
     5341 agaaatctat ttcaaagtct gcagagacaa tagcatcctc ccacctttag ataaagagaa
     5401 aggtgaaact ctgctgagcc ccctagtgat gtgcgggccc catggcctca agttcctgaa
     5461 gcctgtggag ctacgcttgc cacactgtga ccctaaaact tggcaaaaca agtgtcttcc
     5521 tggagatccg aattaccttg ttggagccaa ctgtgtttct gtcctgattg accactttta
     5581 attcttagag tctagcagct ggactaagca gtgtgaacat ggattgaact tactgaatgg
     5641 aaccactcta atgagtattc tattttctta gaatttatac tgcagttagt agtattaaac
     5701 atttgttgga actgataaag gttagtgagc atgcccctga accacgatca gaaaacatgc
     5761 tacaagctgt gtgttattga gtggagaact gtcaggcatt ggctagaggt tcaaagatat
     5821 tttgctttgt aatgattttt gtactttttt atggtcactg cttaacttca catactgatt
     5881 tccgttaaaa ataccagcca gtaaatgggg gtgcatttga gttttgttct ttccaaagta
     5941 cactcaacct ttactatggc cttggcctag catacacatt tattttatta tgcatgaggt
     6001 aatgtgcaca cattttttac aaatgcacct ggaatatata accagtgtag tggatttaac
     6061 agaaatgtac agcaggggga tttataactt ggggagggag gggcaaatga agacaattcc
     6121 ttattgtata tgaaaacaca tttctcttag ggaaggacac caaagcatgt gagcccagtt
     6181 ccatggccgc tgaatctata aattaacata tcaccacaga catccaacca gcaggaatgc
     6241 cttaccctca tggttttcat tcttagatca tttcgctctg tagtactaag tttttatgag
     6301 tttgtgcgta cctagatact gtatcatgga aaagactgag gaaattgtgg acttgatggt
     6361 ttcggaaatg tgtaaatcac ctggaagaaa gtaatggtgt gacttaaaat attttttttt
     6421 gacaagggag agtggttggt ggtcttctgt tctttgggct atgcatctga gatgtttgat
     6481 gtgttcagga cgcatgtaca taatgcgtgc ataccacttt tgttcttggt ttgtaaatta
     6541 acttttataa actttacctt tttatacata aacagaaccg agtttctaag gctacctttg
     6601 tattctctcc tgtacctctt gagccttgaa ctttgacctc tgcagcaata aagcagcatt
     6661 tctacacata taaggtcatt tttttaagaa aaagaatgca cagagttgtt acatttttaa
     6721 gtgctgcatt taaaagatac agttactcta gtttgattaa attcttgcaa agtatccctt
     6781 ctgtaaaatt tgtgatacaa tgctgtgccc taaagtgtat ttttttacta atagtttatt
     6841 atggcacatc agcacgattt ctgtttagat aatacaccac tacattctgt taataatcat
     6901 taggtgtgaa aggatttctt ttgtggttat taaaaatctc aaatttctaa atctgcaaga
     6961 ataaaacttt ttaaaataca
//
LOCUS       NM_001437538            2970 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus membrane spanning 4-domains A10 (Ms4a10),
            transcript variant 1, mRNA.
ACCESSION   NM_001437538 XM_063286965
VERSION     NM_001437538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 3, 2025 this sequence version replaced XM_063286965.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.6310.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000001.1  217049289-217049369 c
            82-277              JAXUCZ010000001.1  217043294-217043489 c
            278-397             JAXUCZ010000001.1  217042826-217042945 c
            398-454             JAXUCZ010000001.1  217041832-217041888 c
            455-586             JAXUCZ010000001.1  217040014-217040145 c
            587-697             JAXUCZ010000001.1  217038875-217038985 c
            698-819             JAXUCZ010000001.1  217038204-217038325 c
            820-2970            JAXUCZ010000001.1  217034156-217036306 c
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2970
                     /gene="Ms4a10"
                     /note="membrane spanning 4-domains A10"
                     /db_xref="GeneID:293739"
                     /db_xref="RGD:1307478"
     exon            1..81
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    41..43
                     /gene="Ms4a10"
                     /note="upstream in-frame stop codon"
     exon            82..277
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..823
                     /gene="Ms4a10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-spanning 4-domains, subfamily A, member 10"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     10 isoform 1"
                     /protein_id="NP_001424467.1"
                     /db_xref="GeneID:293739"
                     /db_xref="RGD:1307478"
                     /translation="MSRQVPTVTASSAIGQASQWQSPGPSQPAQKVAQPQHLVPDGYL
                     EKPMEGSGLLQKLGGFHIAIAFAHLTFGGYLISTVKNLHLVVLKCWYPLWGAVSFLIS
                     GILATTTVTFPKTSLKILCVVANVISLFCALAGFFVIAKDLFLENPFPWPIWRPYPNP
                     TSYIQRLELTLLCFTFLEIFLSASTAITACRMKRPHAEDKDDTPLIPDTPMELKGLSL
                     GPPPSYKDVTQGNTQHEQNKR"
     misc_feature    272..673
                     /gene="Ms4a10"
                     /note="CD20-like family; Region: CD20; pfam04103"
                     /db_xref="CDD:461174"
     misc_feature    272..673
                     /gene="Ms4a10"
                     /note="CD20-like family; Region: CD20; pfam04103"
                     /db_xref="CDD:461174"
     exon            278..397
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            398..454
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            455..586
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            587..697
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            698..819
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            820..2970
                     /gene="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttccacc tctggctctg tctgaggcag ctctggatag taagggacag ctgaagccca
       61 cagaagaggt ccctgggcca gccagggttt cctaccagag tcaatgtcta gacaagttcc
      121 cacagtgact gccagcagtg ccattggaca agcctctcaa tggcagagcc caggaccttc
      181 ccagcctgca cagaaagtgg cccagcccca gcatctggtt ccggatgggt accttgagaa
      241 acccatggag ggaagtggtc tcctgcagaa gttgggtggc tttcacatcg ccattgcttt
      301 tgcacacctg acctttggtg gttacctgat ctccacagtc aagaatctgc acttggtggt
      361 gttgaagtgc tggtatccac tctggggagc tgtttctttt ctcatttcag ggatcttagc
      421 cacgacaaca gtgacatttc ccaagacctc tctgaaaatt ctgtgtgtgg tagcaaacgt
      481 catcagcttg ttctgcgccc tggccggctt cttcgtcatt gccaaggacc tctttctgga
      541 gaatcctttt ccatggccaa tctggagacc ataccccaac cccacaagct acatccaaag
      601 actagagctg actctgctct gctttacctt cctggagatc ttcctgtcgg cgtccaccgc
      661 cattacagcc tgtaggatga aacgcccgca tgcagaggac aaggatgata cccctctcat
      721 ccctgacaca cctatggaac ttaaaggtct gtcactagga ccaccaccat cctataaaga
      781 tgtgactcaa ggtaacacgc agcacgagca aaataagaga taaagactga gttcctgcag
      841 taccaagtcc atcgccgcct cccatcggct ggagtctgat gatgacacag gcgtgactca
      901 ataaaagcat aactactata aagagaaaca ggggtgctct gagagtgtga tggaaacaga
      961 ggggagtgga gtggagaagc caacaggcct ctcccacgga ggcatcaagg gatgcctatg
     1021 ggtctaactg tccagtgtag gcataaattt ttttacaacc tacttttaat atgggttcaa
     1081 cctctcctct agccagcaga ggttgtagaa gagaaaagtt attaggatgt gggggaagtg
     1141 gacctgttca gcaatagttc tttggaggca agattgatct tctttctcag caattcggtc
     1201 ctgtagcaaa catcaaatat gattcagcag ttgcagacca gacctctagg caggcagaca
     1261 ccaggcacaa accagcagct atagtccagt cctttcagca ggcagaaccc aggcagctgt
     1321 agttcaatcc tgaagaaaac gccaggctcg ccaacagacc tgaggtgagg ccaacaaagc
     1381 agcaagcatt tgcaagaacc tcatgagcaa gtttctctta atggtggcat taccacaagt
     1441 tgagctcaac aacgctatgt aaggcgatcc aatagatgcc tgtcgatagc aaagaatagt
     1501 ggaatggagc aaaccaagcc aatgcttagt gctcatctcc cactgtctgg gaggccatgt
     1561 tgatactcct ttatcaagta tcctttcatg tgtttgctat atcaaaacat cctttcacct
     1621 gtgtctgctt caggaaaaca gcctttacct ttttgcttta gcaagacatt gtttctcctg
     1681 tatgcctcag aaaaacatca tttgatgtaa ctaacgttcc aaagaaacta gaaatttcca
     1741 cttcagtcca ggctctgcca ctgtgtctgt gtctgtgtgt gtttattctg tgtgtgtgtc
     1801 tgtgtgtctg tgtctgtcta tgtgtgtgtg tgtctgtgtg tatgtctatg tatgtatgtc
     1861 tgtgtgtctg tctatctgtc tgtgtgtgtg tctgtgtgtg tgtgtctgtg tgtgtctgtg
     1921 tgtatgtctg tgtgtctgtc tgtgtgtgtc tgtgtgtgtg ggtgtgtgtg tgtctgtgtg
     1981 tctgtgtgtg tgtctgtgtg tgtctgtgtg tctgtgtgtg tgtgtatgtg tgtgtttatg
     2041 tctgtgtgtg tgtctgttct gtgtgtgttt atgtctctgt gtgtgtgtgt ctgtgtgtgt
     2101 ctgtgtctgt gtgtctgtgg gggagtgtgg gtgtctgtgt gtgtctgggt gtgtgtttgg
     2161 gtgtgtctgg atgtgtgtct gtgtttgtgt gtctctgtgt gtgggtgtgg gtgtatgtct
     2221 gtgtgtctgt gtgtgtgtct gtgtgtgttt atatctgtgc gtgtctgtgt gtgtttatat
     2281 ctgcgtgtgt ctgtgtgtgt gtgtgttgag catgtgtgta tgcatgttta catgtgtcag
     2341 ggcatgggag gtatacatgc atatgtgtgc atatggcgac tattgatgtc agaaatcatc
     2401 ctagatccaa tgaagaggtc tgaagtgtat cctccatcct tcttcctctt cattcactga
     2461 agcaggacct ctcactctaa cccagagctt gccaatatgg ctattgctgc tgactagctc
     2521 tgggcatccc atatctctct gccttctgag cctggaatta caggtgagct accatgcccc
     2581 cacccagtct aggttccagg gatctggggt ctgctggcta gttttatgtc aacttaacat
     2641 aaactaaagt cacctgagag gggggaacct aaattaagaa gatgcctcca taatatcata
     2701 atatgtaaac ctgtactttc ttaactgatg actgatgggg gagggcccag cccattgtgg
     2761 gtggggccat ccctggtctg gtaggcctgg gttctataag aaagcaggtt gagcaaacct
     2821 tggggagcaa gctcgtaagc agcatccctc cacggcctct gcatcagctc ctgcctccag
     2881 gttcctgcca tgtttgagtt cctgtcctgg cttccttcag tgatggccta caatgtgaaa
     2941 gagtaaaccc aataaacact ttcctcccca
//
LOCUS       NM_001437404            2095 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus myotilin (Myot), transcript variant 2, mRNA.
ACCESSION   NM_001437404 XM_006254668
VERSION     NM_001437404.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   von Nandelstadh,P., Ismail,M., Gardin,C., Suila,H., Zara,I.,
            Belgrano,A., Valle,G., Carpen,O. and Faulkner,G.
  TITLE     A class III PDZ binding motif in the myotilin and FATZ families
            binds enigma family proteins: a common link for Z-disc myopathies
  JOURNAL   Mol Cell Biol 29 (3), 822-834 (2009)
   PUBMED   19047374
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Hauser,M.A., Horrigan,S.K., Salmikangas,P., Torian,U.M.,
            Viles,K.D., Dancel,R., Tim,R.W., Taivainen,A., Bartoloni,L.,
            Gilchrist,J.M., Stajich,J.M., Gaskell,P.C., Gilbert,J.R.,
            Vance,J.M., Pericak-Vance,M.A., Carpen,O., Westbrook,C.A. and
            Speer,M.C.
  TITLE     Myotilin is mutated in limb girdle muscular dystrophy 1A
  JOURNAL   Hum Mol Genet 9 (14), 2141-2147 (2000)
   PUBMED   10958653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254668.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37680.1,
                                           SRR26360194.1722900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000018.1  36956191-36956275
            86-506              JAXUCZ010000018.1  36959174-36959594
            507-681             JAXUCZ010000018.1  36963587-36963761
            682-783             JAXUCZ010000018.1  36964671-36964772
            784-830             JAXUCZ010000018.1  36967667-36967713
            831-963             JAXUCZ010000018.1  36968360-36968492
            964-1171            JAXUCZ010000018.1  36969985-36970192
            1172-1337           JAXUCZ010000018.1  36974103-36974268
            1338-1471           JAXUCZ010000018.1  36974795-36974928
            1472-2095           JAXUCZ010000018.1  36975105-36975728
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2095
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="myotilin"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
     exon            1..85
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="upstream in-frame stop codon"
     exon            86..506
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1644
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="isoform 1 is encoded by transcript variant 2; titin
                     immunoglobulin domain protein (myotilin)"
                     /codon_start=1
                     /product="myotilin isoform 1"
                     /protein_id="NP_001424333.1"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
                     /translation="MFNYERPKHFIQSQNPCGSGLQPPGPEVSSFPNQTKQSSIVIQP
                     RQCTEQRFSASSTVSSHITVSSSAYPASQQLAGPNPGQKVTATYNQSPASFLSSILPS
                     QPDYSNSKIPSTVDSNYQQSSVHQPVNAVSSQAAGAKPTPRTPDHEIQGSKEALIQDL
                     ERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDVQDSSQHNPEHARL
                     QVPTSQVRSRSSSRADANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLPA
                     PDVSWYLNGRLVQSDELHKMIVSEKGFHSLIFEVVRASDAGPYACVARNRAGEATFTV
                     QLDVLAKEHKRAPMFIYKPQSKKVFEGESVKLECQISAIPPPKLFWKRNNEMVQFNTD
                     RISLYHDNAGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTPPAPK
                     QLRVRPTFSKYLALNGKGLDVKQAFNPEGEFQRLAAQSGLYESEEL"
     misc_feature    895..1167
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    895..1167
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    946..960
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    946..960
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    985..999
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    985..999
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1063..1077
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1063..1077
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1105..1122
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1105..1122
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1144..1155
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1144..1155
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    1192..1467
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1192..1467
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="C-terminal immunoglobulin (Ig)-like domain of
                     myotilin; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_Myotilin_C; cd05892"
                     /db_xref="CDD:409473"
     misc_feature    1192..1203
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1192..1203
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409473"
     misc_feature    1210..1227
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1210..1227
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409473"
     misc_feature    1240..1263
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1240..1263
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409473"
     misc_feature    1282..1302
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1282..1302
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409473"
     misc_feature    1303..1314
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1303..1314
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409473"
     misc_feature    1333..1353
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1333..1353
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409473"
     misc_feature    1360..1392
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1360..1392
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409473"
     misc_feature    1402..1428
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1402..1428
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409473"
     misc_feature    1432..1467
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     misc_feature    1432..1467
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409473"
     exon            507..681
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            682..783
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            784..830
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            831..963
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1171
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1337
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1471
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..2095
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccacac gatcctgagc aaggagatgc ttcttccttc tcttcagtag tgggttgaga
       61 caagctggcc ccttctgagc taagggcttg ccaccccacg gtcaggagtc tatccttctg
      121 ggagcaaatc catcttccat ataccagcta agcatgttta actacgaacg tccaaaacac
      181 ttcatccagt cccaaaatcc atgtggctcc gggctgcagc ctccaggacc tgaagtctcc
      241 agcttcccta accagaccaa acagtcttcc atcgtcatcc agcctcgcca atgcaccgag
      301 cagagatttt ctgcttcctc cacagtgagc tctcacatca ccgtgtcttc ctctgcttat
      361 cctgcttccc agcagctggc tggccccaac cccggtcaga aggttactgc tacctataac
      421 cagtccccag ccagcttcct cagttctata ttaccgtctc agcctgatta cagtaacagt
      481 aaaatcccat ccactgtgga ctccaactat caacaatcct cagttcacca acctgtaaat
      541 gccgtgtcat cccaagctgc aggtgctaag cccactccaa ggactcctga ccacgaaatc
      601 caaggatcaa aagaagcatt gattcaagat ttggaaagaa agctgaaatg caaagacacc
      661 cttcttcata atggaaacca aagactgacc tatgaggaga agatggctcg caggttgtta
      721 ggaccgcaga atgctgctgc tgtgtttcaa gctcaaaaca gtgacgtcca agattcgtca
      781 cagcataacc cagaacatgc acggctgcaa gttcccacat cacaagtaag aagtagatcg
      841 tcctccagag cagacgcaaa tgaccaggat gccatccagg agaagtttta cccaccacgc
      901 ttcattcaag tgccagaaaa tatgtccatc gaagaaggaa gattctgcag aatggacttt
      961 aaagtgagtg gactgccagc ccctgatgtg tcatggtatc taaacgggag actggtgcaa
     1021 tcagatgagt tgcacaaaat gatagtgtca gagaagggtt tccactccct catctttgaa
     1081 gtggtcagag catcagatgc agggccatat gcatgtgtag ccagaaacag agctggagaa
     1141 gccaccttca cagtgcagct ggatgttctg gcaaaagagc acaaaagagc accgatgttt
     1201 atctacaaac cacagagcaa aaaggttttt gagggagaat cagtgaagtt agagtgccag
     1261 atctcagcta tccctccacc aaagcttttc tggaaaagaa acaacgaaat ggttcagttc
     1321 aacactgacc ggataagctt atatcatgat aatgctggaa gagtaacttt actgataaaa
     1381 gatgtaaaca agaaggatgc tgggtggtat acagtgtcag cagtcaatga agctggcgtg
     1441 accacgtgta acacaagatt agatgtcaca gcccgtccaa accaaactcc cccagctcct
     1501 aagcaactgc gtgttcgacc aactttcagc aaatatttag ccctaaatgg gaaaggtttg
     1561 gatgtgaaac aagctttcaa ccctgaagga gagtttcagc gtctggcagc tcaatccgga
     1621 ctctatgaaa gtgaagaact ttaataactt tgcccacagg gaaaacagag cttcactcct
     1681 ccaatggatc tgataacatt gtgaaaaaaa atccatggtt gtattaacag attgtgactt
     1741 tacttaggtc atatactaac tcccatttag aatgttattc accctctgac tctggcacaa
     1801 cgtgtctatt cctctgacct gtgaagccgg cagtaaacta agtaaatgag tttgtattat
     1861 aagagactgt tttaagatac agtgtcttaa cactgaagtc atgcacattt aacaactatg
     1921 agttatgaac cagaaacttt ttaaatgcca ctaattcttg cagtaaagtg tatgggtatt
     1981 gcctaacaga ctttatttac ctgttttctc ttataggaat actaacatgg tatagattat
     2041 ctgagtgttc cacaatttca tgtcaaaaga gaataaaatt caagtagtta agaca
//
LOCUS       NM_001437566            1483 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus STN1 subunit of CST complex (Stn1), transcript
            variant 1, mRNA.
ACCESSION   NM_001437566 XM_006231472
VERSION     NM_001437566.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Iles,M.M., Bishop,D.T., Taylor,J.C., Hayward,N.K., Brossard,M.,
            Cust,A.E., Dunning,A.M., Lee,J.E., Moses,E.K., Akslen,L.A.,
            Andresen,P.A., Avril,M.F., Azizi,E., Scarra,G.B., Brown,K.M.,
            Debniak,T., Elder,D.E., Friedman,E., Ghiorzo,P., Gillanders,E.M.,
            Goldstein,A.M., Gruis,N.A., Hansson,J., Harland,M., Helsing,P.,
            Hocevar,M., Hoiom,V., Ingvar,C., Kanetsky,P.A., Landi,M.T.,
            Lang,J., Lathrop,G.M., Lubinski,J., Mackie,R.M., Martin,N.G.,
            Molven,A., Montgomery,G.W., Novakovic,S., Olsson,H., Puig,S.,
            Puig-Butille,J.A., Radford-Smith,G.L., Randerson-Moor,J., van der
            Stoep,N., van Doorn,R., Whiteman,D.C., MacGregor,S., Pooley,K.A.,
            Ward,S.V., Mann,G.J., Amos,C.I., Pharoah,P.D., Demenais,F.,
            Law,M.H., Newton Bishop,J.A. and Barrett,J.H.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Wan,M., Qin,J., Songyang,Z. and Liu,D.
  TITLE     OB fold-containing protein 1 (OBFC1), a human homolog of yeast
            Stn1, associates with TPP1 and is implicated in telomere length
            regulation
  JOURNAL   J Biol Chem 284 (39), 26725-26731 (2009)
   PUBMED   19648609
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_006231472.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.6414.1,
                                           SRR26360172.995289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000001.1  256370562-256370776 c
            216-391             JAXUCZ010000001.1  256369932-256370107 c
            392-487             JAXUCZ010000001.1  256363461-256363556 c
            488-556             JAXUCZ010000001.1  256358861-256358929 c
            557-724             JAXUCZ010000001.1  256351463-256351630 c
            725-848             JAXUCZ010000001.1  256350493-256350616 c
            849-1020            JAXUCZ010000001.1  256348306-256348477 c
            1021-1140           JAXUCZ010000001.1  256344882-256345001 c
            1141-1213           JAXUCZ010000001.1  256342471-256342543 c
            1214-1483           JAXUCZ010000001.1  256336916-256337185 c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1483
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="STN1 subunit of CST complex"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
     exon            1..215
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..391
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    232..234
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="upstream in-frame stop codon"
     CDS             238..1371
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 1; CST complex subunit STN1; suppressor of cdc
                     thirteen homolog; oligonucleotide/oligosaccharide-binding
                     fold containing 1; STN1, CST complex subunit"
                     /codon_start=1
                     /product="CST complex subunit STN1 isoform 1"
                     /protein_id="NP_001424495.1"
                     /db_xref="GeneID:294025"
                     /db_xref="RGD:1305637"
                     /translation="MPEPCLLMQCESSPKEEEIPSLFWGLDPVFLAFAKLYIKDILEM
                     KESQQVPGMYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKRPSNA
                     ESSSDPAILSTSRELSMTSQLKKLQETIEQKTKIGIGDIIRVRGYVRMFREEREICAT
                     IYYKVDDPVWNMQIARMLELPELYKKVYDQPFRNPALKEEEALNSKDTLDLAGLTALL
                     SEKVKEFLQEKKVQSFYQKELEMVEPLQSLASQPVTHSTCSDQVELKNDAASDIHSVF
                     KNALHLLQEKGFVFQRDGGSDKLYYVTSKDKDLHQKIYQIIKEDCQKPNHVEKGCHLM
                     HVLNCVLLNLRWDLNKAVLQQVLELLEDQSDIVSTGDHYYTAF"
     misc_feature    430..732
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    430..732
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="A subfamily of OB folds similar to that found in
                     human OB fold containing protein 1 (hOBFC1). Members of
                     this group belong to the Replication protein A subunit 2
                     (RPA2) family of OB folds. RPA is a nuclear ssDNA binding
                     protein (SSB) which appears to be...; Region: hOBFC1_like;
                     cd04483"
                     /db_xref="CDD:239929"
     misc_feature    order(430..432,658..660,664..666,670..672,724..726)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(430..432,658..660,664..666,670..672,724..726)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(445..453,478..489,493..495,511..519,523..525,
                     655..657,676..684,703..711)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    order(445..453,478..489,493..495,511..519,523..525,
                     655..657,676..684,703..711)
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239929"
     misc_feature    871..1368
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     misc_feature    871..1368
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /note="CST, complex subunit STN1, C terminal; Region:
                     STN1_2; pfam09170"
                     /db_xref="CDD:462701"
     exon            392..487
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..556
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..724
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..848
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1020
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1140
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1213
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1483
                     /gene="Stn1"
                     /gene_synonym="Obfc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcgcaa ccggaactat ttcggcaatc ttggccaact gctcctgctc cgggagaggc
       61 tgtaaaccgc tctgattctg cctccttttc ctttcctccg ctcttcccag aaggtgaaat
      121 gtcgaagagt ggatagacac acctccaggg cccaaagtcc acggccacag gggcgccatt
      181 cactctccgg actcattcgt taaaactcct ttgggagtct tggctcaggg ttagcagatg
      241 ccagaacctt gccttttgat gcagtgcgaa tccagtccaa aagaagagga gatcccgtcc
      301 ctcttttggg gtctggatcc cgtgtttcta gcctttgcaa aactctacat caaggacatc
      361 ctggagatga aggagtccca acaagtgcca ggcatgtatt tttacaatgg acatccaata
      421 agacgggtgg atatcatggg agctgtcatc agtgtgaaag agagagagac tttctacagc
      481 tatggagtgg atgacgccac aggggttata aactgtgtgt gctggaaaag gccaagcaat
      541 gccgagtctt catcagaccc agctattctg agcacttcga gagaactcag catgacctca
      601 cagcttaaga aactgcagga gaccattgag cagaaaacca agatcgggat tggggatatc
      661 atccgagtcc gaggctacgt gcgtatgttc cgagaagagc gagagatctg tgccaccatt
      721 tattataagg tggacgatcc agtgtggaac atgcaaattg caaggatgct tgagctgcca
      781 gagctctaca agaaggtgta tgaccagccc ttccggaacc cagccctaaa ggaggaagag
      841 gcactaaaca gtaaagacac tttggatctc gctggcctca cggctttgtt gagtgagaaa
      901 gttaaagaat ttctccagga gaagaaagtg caaagcttct accagaagga gctggaaatg
      961 gtggagccct tgcagtctct ggccagtcag cccgtgaccc acagcacgtg ctcggaccaa
     1021 gtggagttaa agaacgacgc cgcttctgac atacacagtg tgtttaagaa tgctctgcac
     1081 ctgcttcagg aaaaggggtt cgtgttccag agagacggtg gctccgataa gctgtactat
     1141 gttaccagta aggacaaaga cctgcaccag aagatctacc agatcattaa ggaagactgt
     1201 cagaaaccaa atcatgtgga gaagggctgc cacttgatgc acgtcctgaa ctgcgtgctc
     1261 ctcaacctcc gctgggacct gaacaaggct gtgctgcagc aggtgctgga gctcctggag
     1321 gaccagagcg acattgtgag tactggagac cactactaca cggccttctg agcagagcca
     1381 cggagaggca gcaggcagct ttaccccagg ttctgctccc aggcgttgta gagacttatt
     1441 tgtgtataat cccctaataa agtctgatac agccacagga aaa
//
LOCUS       NM_001436923            1043 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus troponin I1, slow skeletal type (Tnni1),
            transcript variant 1, mRNA.
ACCESSION   NM_001436923
VERSION     NM_001436923.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Lin,Y.H., Schmidt,W., Fritz,K.S., Jeong,M.Y., Cammarato,A.,
            Foster,D.B., Biesiadecki,B.J., McKinsey,T.A. and Woulfe,K.C.
  TITLE     Site-specific acetyl-mimetic modification of cardiac troponin I
            modulates myofilament relaxation and calcium sensitivity
  JOURNAL   J Mol Cell Cardiol 139, 135-147 (2020)
   PUBMED   31981571
  REMARK    GeneRIF: Site-specific acetyl-mimetic modification of cardiac
            troponin I modulates myofilament relaxation and calcium
            sensitivity.
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Liu,W., Kuang,H., Xia,Y., Pope,Z.C., Wang,Z., Tang,C. and Yin,D.
  TITLE     Regular aerobic exercise-ameliorated troponin I carbonylation to
            mitigate aged rat soleus muscle functional recession
  JOURNAL   Exp Physiol 104 (5), 715-728 (2019)
   PUBMED   30820991
  REMARK    GeneRIF: regular aerobic exercise appeared to have antioxidant
            effects in the muscle that reduced TNNI1 slow carbonylation and
            promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and
            TNNI1 expression for skeletal muscle contraction regulation
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Potluri,P.R., Chamoun,J., Cooke,J.A., Badr,M., Guse,J.A., Rayes,R.,
            Cordina,N.M., McCamey,D., Fajer,P.G. and Brown,L.J.
  TITLE     The concerted movement of the switch region of Troponin I in
            cardiac muscle thin filaments as tracked by conventional and pulsed
            (DEER) EPR
  JOURNAL   J Struct Biol 200 (3), 376-387 (2017)
   PUBMED   28864299
  REMARK    GeneRIF: Troponin I interaction with calcium and Troponin C in
            cardiac muscle
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Cheng,Y., Rao,V., Tu,A.Y., Lindert,S., Wang,D., Oxenford,L.,
            McCulloch,A.D., McCammon,J.A. and Regnier,M.
  TITLE     Troponin I Mutations R146G and R21C Alter Cardiac Troponin
            Function, Contractile Properties, and Modulation by Protein Kinase
            A (PKA)-mediated Phosphorylation
  JOURNAL   J Biol Chem 290 (46), 27749-27766 (2015)
   PUBMED   26391394
  REMARK    GeneRIF: these results suggest that cTnI(R146G) and cTnI(R21C)
            blunt PKA modulation of activation and relaxation kinetics by
            prohibiting cardiac-specific N-terminal interaction with the cTnI
            inhibitory peptide.
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Christopher,B., Pizarro,G.O., Nicholson,B., Yuen,S., Hoit,B.D. and
            Ogut,O.
  TITLE     Reduced force production during low blood flow to the heart
            correlates with altered troponin I phosphorylation
  JOURNAL   J Muscle Res Cell Motil 30 (3-4), 111-123 (2009)
   PUBMED   19507043
  REMARK    GeneRIF: These findings suggest that altered TnI function, due to
            changes in the distribution of phosphorylated sites, is an early
            contributor to reduced contractility of the heart.
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Takimoto,E., Soergel,D.G., Janssen,P.M., Stull,L.B., Kass,D.A. and
            Murphy,A.M.
  TITLE     Frequency- and afterload-dependent cardiac modulation in vivo by
            troponin I with constitutively active protein kinase A
            phosphorylation sites
  JOURNAL   Circ Res 94 (4), 496-504 (2004)
   PUBMED   14726477
  REMARK    GeneRIF: A novel role is described for cardiac TnI PKA
            phosphorylation in the rate-dependent enhancement of systolic &
            diastolic function in vivo & afterload sensitivity of relaxation.
            This has implications for cardiac failure.
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Westfall,M.V. and Borton,A.R.
  TITLE     Role of troponin I phosphorylation in protein kinase C-mediated
            enhanced contractile performance of rat myocytes
  JOURNAL   J Biol Chem 278 (36), 33694-33700 (2003)
   PUBMED   12815045
  REMARK    GeneRIF: troponin I phosphorylation has a role in protein kinase
            C-mediated enhanced contractile performance of myocytes
REFERENCE   8  (bases 1 to 1043)
  AUTHORS   Metzger,J.M., Michele,D.E., Rust,E.M., Borton,A.R. and
            Westfall,M.V.
  TITLE     Sarcomere thin filament regulatory isoforms. Evidence of a dominant
            effect of slow skeletal troponin I on cardiac contraction
  JOURNAL   J Biol Chem 278 (15), 13118-13123 (2003)
   PUBMED   12551900
REFERENCE   9  (bases 1 to 1043)
  AUTHORS   Huang,X., Pi,Y., Lee,K.J., Henkel,A.S., Gregg,R.G., Powers,P.A. and
            Walker,J.W.
  TITLE     Cardiac troponin I gene knockout: a mouse model of myocardial
            troponin I deficiency
  JOURNAL   Circ Res 84 (1), 1-8 (1999)
   PUBMED   9915769
REFERENCE   10 (bases 1 to 1043)
  AUTHORS   Koppe,R.I., Hallauer,P.L., Karpati,G. and Hastings,K.E.
  TITLE     cDNA clone and expression analysis of rodent fast and slow skeletal
            muscle troponin I mRNAs
  JOURNAL   J Biol Chem 264 (24), 14327-14333 (1989)
   PUBMED   2760067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215749.1, FQ216094.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000013.1  49780993-49781048
            57-104              JAXUCZ010000013.1  49781506-49781553
            105-134             JAXUCZ010000013.1  49784766-49784795
            135-138             JAXUCZ010000013.1  49785490-49785493
            139-180             JAXUCZ010000013.1  49787394-49787435
            181-312             JAXUCZ010000013.1  49787901-49788032
            313-402             JAXUCZ010000013.1  49789943-49790032
            403-579             JAXUCZ010000013.1  49791065-49791241
            580-689             JAXUCZ010000013.1  49792024-49792133
            690-1043            JAXUCZ010000013.1  49793032-49793385
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1043
                     /gene="Tnni1"
                     /note="troponin I1, slow skeletal type"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
     exon            1..56
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    49..51
                     /gene="Tnni1"
                     /note="upstream in-frame stop codon"
     exon            57..104
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..134
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..687
                     /gene="Tnni1"
                     /note="troponin I, skeletal, slow 1; troponin I type 1
                     (skeletal, slow)"
                     /codon_start=1
                     /product="troponin I, slow skeletal muscle"
                     /protein_id="NP_001423852.1"
                     /db_xref="GeneID:29388"
                     /db_xref="RGD:621765"
                     /translation="MPEVERKSKITASRKLMLKSLMLAKAKECWEQEHEEREAEKVRY
                     LSERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVL
                     DLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGD
                     WRKNVEAMSGMEGRKKMFDAAKSPTSQ"
     misc_feature    127..267
                     /gene="Tnni1"
                     /note="propagated from UniProtKB/Swiss-Prot (P13413.2);
                     Region: Involved in binding TNC"
     misc_feature    127..129
                     /gene="Tnni1"
                     /note="N-acetylproline.
                     /evidence=ECO:0000250|UniProtKB:P02645; propagated from
                     UniProtKB/Swiss-Prot (P13413.2); acetylation site"
     misc_feature    166..561
                     /gene="Tnni1"
                     /note="Region: Troponin; pfam00992"
                     /db_xref="CDD:460018"
     misc_feature    166..561
                     /gene="Tnni1"
                     /note="Region: Troponin; pfam00992"
                     /db_xref="CDD:460018"
     misc_feature    295..297
                     /gene="Tnni1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P13413.2); phosphorylation site"
     misc_feature    412..477
                     /gene="Tnni1"
                     /note="propagated from UniProtKB/Swiss-Prot (P13413.2);
                     Region: Involved in binding TNC and actin"
     exon            135..138
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..180
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..312
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..402
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..579
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..689
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1043
                     /gene="Tnni1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctgccgt ctgtggtgag gctcgggcca gcctagctcc acgaggacta aactaggtgc
       61 tttgagctct cttcacccgt ctcatctgca caggacacca acaggtgctg ccttgttacc
      121 accatgccgg aagttgagag gaaatctaag atcactgcct cccgtaaact catgctgaag
      181 agcctgatgc tagccaaggc caaggagtgc tgggagcagg agcacgagga gcgagaggct
      241 gagaaggtgc gttacctctc ggagcgcatc cctacgctgc agacccgcgg tctttccctc
      301 agcgcccttc aggacttatg ccgagagctc catgccaagg tggaggtggt ggatgaggag
      361 cgctatgata tcgaagccaa atgcctccac aacacgagag agatcaagga cctgaagctg
      421 aaggtgctgg acctccgtgg gaagttcaag cgtccacccc tgcgccgggt ccgtgtctca
      481 gccgacgcca tgctccgagc cctactgggt tccaaacaca aggtgtccat ggatctgcgg
      541 gccaacctca agtctgtgaa gaaagaagac acagaaaagg agcggccagt ggaggtggga
      601 gactggagga agaacgtgga ggccatgtct ggcatggaag gccgcaagaa gatgttcgat
      661 gctgccaagt ccccaacctc gcagtagagg tcggcttgct gaatggcact ctgggtcacg
      721 ctttggtccc cttccagccc cactcaccta tccttctgcc catgcctgga gcccttcctc
      781 cctccagctc tactatgccc acctttgaag ccaggatgag tgcacacaga ggggaagaga
      841 gacgctggtg cctgagacct cattccggca gtgtgggctt acagtaccca ccgggcatgc
      901 tggggttatc cagacacccc aaggggccct aggctgagga gggaggcaga gagaatgcct
      961 tcgcagcagc cccatattgc ttccctccac ttctgttgct atctgcagtg ttcccaagtt
     1021 ctccattaaa aaaatccagg gta
//
LOCUS       NM_001436972            5285 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus Myb/SANT DNA binding domain containing 3
            (Msantd3), transcript variant 1, mRNA.
ACCESSION   NM_001436972 XM_039110241
VERSION     NM_001436972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5285)
  AUTHORS   Oleskevich,S., Leck,K.J., Matthaei,K. and Hendry,I.A.
  TITLE     Enhanced serotonin response in the hippocampus of Galphaz protein
            knock-out mice
  JOURNAL   Neuroreport 16 (9), 921-925 (2005)
   PUBMED   15931062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 25, 2025 this sequence version replaced XM_039110241.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.19279.1,
                                           SRR26643297.18947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000005.1  67661856-67662024
            170-620             JAXUCZ010000005.1  67673780-67674230
            621-5285            JAXUCZ010000005.1  67683307-67687971
FEATURES             Location/Qualifiers
     source          1..5285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5285
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT DNA binding domain containing 3"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
     exon            1..169
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     exon            170..620
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1030
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain containing 3"
                     /codon_start=1
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 3"
                     /protein_id="NP_001423901.1"
                     /db_xref="GeneID:362516"
                     /db_xref="RGD:1308165"
                     /translation="MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIAL
                     KQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSGSPLLS
                     THVLDKEKIGSMLPEQLYFLQSPPEEEPEYHQDAAAQESFAVSNRELCDDEKEFVHFP
                     VCEGTSQPEPSCSAVRITANKNYRSKTPQEGALKKMHEEEHHQQMSILQLQLIQMNEV
                     HVAKIQQIERECEMAEEEHRIKMEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP"
     misc_feature    230..463
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     misc_feature    230..463
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /note="Myb/SANT-like DNA-binding domain; Region:
                     Myb_DNA-bind_5; pfam13873"
                     /db_xref="CDD:433544"
     exon            621..5285
                     /gene="Msantd3"
                     /gene_synonym="RGD1308165"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggccgcgg agcgcgcggc ggggcctggc cggccggggg cgcgcggccg cccggcgcct
       61 ggagcccgcg gccctgccgg ccgcccagcc cgccagagca gcccaggccg ccgcgcccgc
      121 gcctccgctc ccctccccgg gactcgcggc cgccgcgccg ccgctgcagg ctagccaacg
      181 accaggagaa atagagtgga aaatgcaaaa caacgaaatc attaaacctg ccaagtactt
      241 ctcagagctg gagaagagca tcttgcttgc cttagtagag aagtacaagt atgtgctgga
      301 gtgcaagaaa agcgacgcgc ggactattgc tctcaagcag cggacctggc aggccttggc
      361 ccatgagtac aactcgcagc ccagcgtgtc gctgcgggac ttcaaacagc tgaagaagtg
      421 ttgggagaac atcaaggctc ggaccaaaaa aattatggcc cacgagagga gggagaaggt
      481 gaagcgcagc gggagtccgc tgctgagcac gcacgtcctg gacaaggaga agatcggcag
      541 catgctaccg gagcagctct acttccttca gagcccgccc gaggaggagc ccgagtacca
      601 ccaggacgca gccgcccaag agtcctttgc tgtttcaaat cgagaactgt gcgacgatga
      661 gaaagagttt gtccactttc ctgtatgtga ggggacctca caacctgaac cttcgtgttc
      721 agccgtcaga ataacagcca ataagaacta caggagcaaa acccctcagg aaggtgcttt
      781 aaaaaagatg cacgaggagg agcaccatca gcagatgtcc atcctgcagc tccagctgat
      841 ccagatgaat gaggtgcacg tggccaaaat ccagcagata gaacgggaat gtgagatggc
      901 cgaggaggaa caccggatca agatggaggt cctcaacaag aagaagatgt actgggagag
      961 aaagctacag actttcacca aggagtggcc cgtctcctca tttaaccgac cctttcccaa
     1021 ttcaccctga gactggggga tggctccctg tagttaacct gtattggcaa ggcagtgtgg
     1081 gatgtggcct gcgtggtcag tagcccgtga cagacctacg gctaggtgaa ttagagtggt
     1141 actagtcact tattaagaac acattcaggt aaacagctgc accccgtcta cccctaaagt
     1201 ggccaagaag ctgttacagt cttctagaag tcaccactac gcgtgctata attctgaatg
     1261 taatgttctt aattagaatt catagaggaa ccatgtgcga gtgttgtatt ttttttttaa
     1321 gacatgcaag tgtggtgata taggagtgag gctggtggtt ctgacctcat ctgtcagtgg
     1381 ggttttgttt gttttcagct gacagtggcg cttttccaca caggtgtgaa gcccacccat
     1441 tgtgtggctg taccttggct gtttctccac ctttcagtgt actctgagtg tgggcgtttg
     1501 aagagcccag cctttagaag ggtgtttcct aatgtgggtt accaactgcc tttttagact
     1561 tttccccaca gaggctttcc aaccagggct ccagccgtgg cggtttcagt agaagtaggg
     1621 atgtaacaac tggagggctt aatgttcatt taggtatcta catcctgttg gttttttatt
     1681 aaaaatgtct taaaatttta tagttacact gtgtatgttt ttaaaggtgc tgctatccca
     1741 gcccggatcc ctcccaactt tttactgctg agtgaatggt tgtctggact ttttagtctc
     1801 tcactccctt aggagaggcc ccgccctcgc tgtgttcatg ctgtatgctg gtgttgacca
     1861 ccgatcaggg ttagggtgac caacatgttt ggaaacgtgg atggataaat gggtgttttg
     1921 atggagctgt gatgtttctg ctgtaacctg atgctttaaa aaaaattttt tttgttttta
     1981 agagttggga cagtagtagc tggaggcggc agggggaccc ttaagagcca gtgttctaag
     2041 tgtggctctg gctaactccc taaaacctca agctggtgct tcctgtccgc agaatgaggg
     2101 agttgaggag acatttggag cctgtttcag ctccttagcc acgttgcggc ttgtgcgact
     2161 ctctgcatgc actctgactt catggcagcc cggagggcat gagtctacac agagttgtct
     2221 ctagaaatgg ccaagctttg gaatttttcg tcccgggcct gttaggtttt gtatggttca
     2281 caccgactca cagtttgtgc actgcatata atgtaagcag atatcaattt tgtacattga
     2341 atctatttta aatatcttag aggaattagt ccgttatttt agatatatcc tgcagtgaga
     2401 gactagaagt aggatccttc catgaggatt tctgtcgttc atttttatca gatgaagcct
     2461 tcagagagtg aatggtttga aagtcacgtt cgatggtacg cagaaggtag gactccactc
     2521 cctgtgtcct gcctccggat agacagggat ggacagcaca aatctaggtg cagagggctg
     2581 cctttgcttc acgtactgat ctaaacatcc tcttaatatc acatccagag taaggcatga
     2641 ggtctgttct cacaagctcc cagattaggc ctgatctgat gctctgctca acacatctct
     2701 gaatgacaag gacttaaagg gaccttagga agttttccat ctcttacata catagatgtg
     2761 gtggttacga ttttctaaaa attcatgact taaactcaca aacagccaca tagaataaca
     2821 aaaattgcaa cgcattttaa ttggactata aaagcattga actaattcct gtctgaacaa
     2881 atacaggata attaagccag agcataaaac cccttgctgt actgctaatg gtatttatga
     2941 gtttacaata gtagcttgcg atatttggct atgtgttagg aataatattt tataaataat
     3001 tagtcccact gggtctcact tccagagggt tctgagtcag ttgacttggg gcggggctgg
     3061 ctgttgggta tttttggaag ctttctaggt gattaggatg cagagttgag attgagagcc
     3121 actttgtacg gcttacgaat gtatttcagt tgcttcttaa ttccacaaag ccatggagaa
     3181 ggaaggaatt gatgttcgga gaagagccca cctggcacca ggcctgtagc cagtaaatag
     3241 caaagaagaa cttcgggctg ggtctcttgg ttccgagatg cacagcccca cctgctgtct
     3301 ttaccctttc ttttgaagcc gagccaagga tgcttgattc tgaggctcga atgacgttac
     3361 acagttgctt gctgaagcag cttcattcat gaacagacag cacatcccag ttcattttgc
     3421 ttttgagctt tttatttcct gaggtagaaa agcaataacc atttcttgac aggaatcgtg
     3481 ggccagatac acataaaaaa atattaagac gtggttctac atcgtgggca ttgcccggga
     3541 gggagggaag aatggaggga gggagggctg gttcgcagct ggctgtagac tcagccggtg
     3601 cacatcttca aatgctctct cagttgaggg cagggagcta agaaaatgga gagcggaatc
     3661 gtagaagcgt ggtatttgag ttgagtctgt ggggctgaca ttttggcagg tagggaaagc
     3721 agagaacatc accagatgac acacaaatgg gagagagaag agtgagctag aggggagttt
     3781 tcaaatctga tcagaaccgt gcaccaggag ggaagttaga agctggaatg gaggggagag
     3841 gagactgcag ttgggatgac aggaaggagg gcttggcttt ggtagccggg atgacaggat
     3901 ccagaggagg tcgtggaaag gagaccaggg tcctgagcga gtggatggtg attgtttttg
     3961 ttagagagga gtggaaggtg ttcacagcta gacttgtgag agaacaatac tgataataac
     4021 cccgaaatga ggggacgata caaatgtcct ctaggatatt tgatgtccta gatgtgccta
     4081 ggcacagaca ctggtatttg ctcccaattc tttgtctacc tcatctctgc agcgacttcc
     4141 tccttgtcac ctgctgttgt tccttctgcc tgttcacttg aactggccct actcagtcct
     4201 cggtcacctg actatttggt acttcctctg tctccaatcc ctccattgtt attaggggca
     4261 cctcattcag tatcgtctat gtcgggttgc actaagatgg ccagaggacg ttgctctttg
     4321 ttgtttgttt ttgatttttg tttttgtctt cgtttttggt cccaagttga ataacaaatc
     4381 cgtggctgga aaagattggt gacttccatg tttgcatatc acagcccttt aaaaaaaatc
     4441 aaatatggaa ccctacccaa tgggtccatg ctttaggaat gtttcaaggg agatgccagg
     4501 acaatcttta gatgcatttt cttttgtttc gcttcagggg gcagagatgg catggtagga
     4561 gaatgcattg gagttgtcaa cagtctctgc cgtgtcaggt caattacatc agcacttggt
     4621 ctagaccaga ggaaaggaat gattgtgcct cctgggaatg tcacaaggac ctgataatta
     4681 tatttggcaa agccatgagg agtggctcgt aatgtcatta ctaagaatta ccctttcagt
     4741 agcatttctg gacgcctgag ctttgcacag ggatggtact tcatttctgt gccttccttc
     4801 ctgctgggcc tcttcccagg tggtccccct actccccctg cccttgctgg ctggctgtat
     4861 tctccctcca acccaatccc cacctcccaa gcccaccttc tgccctcaca gtcgctttca
     4921 ctgtccagtg gtagaggtga aagctacatg ggatgctctt cctgcggatg cccagagggc
     4981 agctccctca gctcctgcgg cagcccctgg acagagctga tttatttcca tgctgcagtc
     5041 gctacctttg tctacctttg tgctcgtggg actcaaagag tcgtgggaaa ggtgaccagg
     5101 aacctgtgac agcaaccagt tctttcccga ctgtgccata tattatgctc ttccacacag
     5161 tttactaatc tctgcctcag tttctccatc tgtaagtgat gtaatactta tctacctccc
     5221 ttggatgttg tgaagattag tatgtgttgg taaagcactt ctgaaataaa gaatgatacc
     5281 aagca
//
LOCUS       NM_001105998            2748 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus cyclin I (Ccni), mRNA.
ACCESSION   NM_001105998 XM_001070498 XM_006250715 XM_214007
VERSION     NM_001105998.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2748)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Mar 26, 2025 this sequence version replaced
            XM_006250715.5, NM_001105998.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223715.1, SRR26643288.50990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               JAXUCZ010000014.1  15164090-15164606
            518-675             JAXUCZ010000014.1  15167954-15168111
            676-804             JAXUCZ010000014.1  15179016-15179144
            805-879             JAXUCZ010000014.1  15179489-15179563
            880-1020            JAXUCZ010000014.1  15180519-15180659
            1021-1251           JAXUCZ010000014.1  15180901-15181131
            1252-2748           JAXUCZ010000014.1  15185388-15186884
FEATURES             Location/Qualifiers
     source          1..2748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2748
                     /gene="Ccni"
                     /note="cyclin I"
                     /db_xref="GeneID:289500"
                     /db_xref="RGD:1309209"
     exon            1..517
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    466..468
                     /gene="Ccni"
                     /note="upstream in-frame stop codon"
     exon            518..675
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1695
                     /gene="Ccni"
                     /codon_start=1
                     /product="cyclin-I"
                     /protein_id="NP_001099468.1"
                     /db_xref="GeneID:289500"
                     /db_xref="RGD:1309209"
                     /translation="MKFPGPLENQRLSSLLERAISREAQMWKVNVPKIPTNQNVSPSQ
                     RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTV
                     EEDEKIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVS
                     TRPQLLFSLPRLSPSQHLAVLTKQLLHCMACNQLLQFKGSMLALAMVSLEMEKLIPDW
                     LPLTIELLQKAQMDSSQLIHCRELVAYHLSALQSSLPLNSVYVYRPLKHTLVTCDKGA
                     FKLHPSSISGPDFSKDNSKPEVPVRGPAAFHLHLPAVSGCKHTSAKRKVEEMEVDDLY
                     DGIKRLYNEDSGSENVGSVCGTDLSRQEGHASPCPPLQPVSVM"
     misc_feature    691..987
                     /gene="Ccni"
                     /note="cyclin box found in cyclin-I (CCNI) and similar
                     proteins; Region: CYCLIN_CCNI-like; cd20526"
                     /db_xref="CDD:410230"
     misc_feature    691..987
                     /gene="Ccni"
                     /note="cyclin box found in cyclin-I (CCNI) and similar
                     proteins; Region: CYCLIN_CCNI-like; cd20526"
                     /db_xref="CDD:410230"
     exon            676..804
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            805..879
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1020
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1251
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..2748
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcccccgc gagcggacgc gctagcgcct ctgtctcgct ttttcttatt ttctccccct
       61 tcccccttcc ttttcttttc ttttttcccc ttcccccctt tcaccatttc ccctcggagg
      121 cgcttccctc gggcaggggc agagccggcc tcaccccgcg cctctccccg gcccccgccg
      181 ccctatggcg agagggcgcc ccctcctcac ccgggcacca gcggcagcgg tcggaggagc
      241 gggaccggcg gcggcggcct ccggcccagg gtcatcatgg aattagttcg ctgagtgacc
      301 cttcggccgc agccgtgcgt cccgcccgag tgcccgcgcc cgccggcccg gtttgccctc
      361 ttctccctcc tcagtcggcc cggccctagt cccgcgcgcc ccgccgccgc gcgctgagga
      421 tcatgaggtg gtaacgggcc cccggatgac cccgcgtcac cactgtgagg cctacagctc
      481 tgccggggag gaggaggagg aggaagagga ggagaaggta gctacatcaa gctgggtggc
      541 aggcagatcc aaagggatat catgaagttt ccaggacctt tggaaaacca gagactgtct
      601 tccctgttgg aaagggcaat ctccagggaa gcccagatgt ggaaggtgaa tgtaccaaaa
      661 atacctacaa accagaatgt ttctccatcc cagagagacg aagtaattca gtggttggcc
      721 aaactcaaat accagttcaa cctttatcca gaaacatttg ctctggcaag cagtcttttg
      781 gataggtttt tagctacagt aaaagctcat ccaaaatatt tgaattgtat tgcaatcagc
      841 tgtttttttc tggctgctaa gactgttgaa gaagatgaga aaattccagt gctaaaggta
      901 ttggcaagag acagtttctg tggatgttcc tcatctgaga ttttgagaat ggagagaatt
      961 attctggata aattgaattg ggatcttcac acagccacac cattggattt tcttcacatt
     1021 ttccatgcca ttgcagtgtc aactaggcct cagttacttt tcagtttgcc cagattgagc
     1081 ccgtctcaac acttggcagt cctgactaag cagctacttc actgtatggc ctgcaaccaa
     1141 cttctgcagt tcaaaggatc catgcttgct ctggccatgg ttagtctgga aatggagaaa
     1201 ctcattcccg attggcttcc tcttacaatt gaactgcttc agaaagcaca gatggacagc
     1261 tcccagttga tccactgtcg ggagctggtg gcatatcacc tttctgctct gcagtcttcc
     1321 ctgcctctaa attccgttta tgtctaccgt cccctcaagc acaccctggt gacctgtgac
     1381 aaaggagcgt tcaaattaca tccctcctct atctcaggcc cagatttctc caaggacaac
     1441 agcaagccag aagtgccagt cagaggtcca gcagccttcc acctccatct ccctgctgtc
     1501 agtgggtgca agcatacctc tgctaaacgg aaagtggagg agatggaggt ggacgacttg
     1561 tatgacggga tcaagcggct ctataacgaa gacagtggtt ccgagaatgt gggctctgtg
     1621 tgtggcactg atttatccag acaagagggc catgcttccc cctgtccacc tttgcagcct
     1681 gtttctgtca tgtagtttca ggtgtcacct tccagtgcac actaaggctg actacttggg
     1741 gtgagactag aaaaccagga aaggctatag agaagggcat gtgctttatc agactgaagt
     1801 gagccaggaa aaaagaaaaa cacttattct tttgtgcaat tacttacaat tcaacataat
     1861 ttaatataaa ggcatatatt tataaactca agatccaaaa tatatttaaa agtaaagcaa
     1921 aagttctttg tactatgtca gttccacttc tttgttaaaa taagtttgcc catgtccaaa
     1981 aaaaattttt aaaaagtaaa tgtttagggg aaagttgcaa actcacagct aggaaccttg
     2041 ttcatgttga cctcttcctc ttgccttttc ttgcctcggt tgaatacttc ataagttgtg
     2101 tgcttgttga tttgtgtatt ctgacttcac tgaacaagta acacccacct tttcttttaa
     2161 agtaattcag gaggcaaatt attttttgtg gcagccatgt ttaatccacg gttcaagtgt
     2221 gttagtctga aaagggcact ttgaagctat ccccatgaat cagtggcagt aggaaaagtt
     2281 ctcttatttt gtcagtctta ttttagtttt tagtttaaaa agattactat tgtccttttt
     2341 tgtttatctt gaagcttaaa aatggcatgt aattaggaca tcttaagcat tttgacgttt
     2401 atataaaaga atttctgata aagttaatat atccaggtgc tcaccaaaga aacatgtatg
     2461 taacatataa gtagattttt gtaactgatc tgttttcact catttataat cagtagaagc
     2521 aactgtctag atattggggc agccctgatt ggagtctaac ttataattga attcagtacc
     2581 ctagttttat attgcgctat taggattttc tttataagga atttttccct tgtttttctc
     2641 tgattggctt ctggaccctg agctcccttt gcagtctgaa gatggcactg cagtcagaac
     2701 cgtgtactgc tgggaaagcc tctggtagca ataaaatgtt gtccttaa
//
LOCUS       NM_001437442            4856 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus ADNP homeobox 2 (Adnp2), transcript variant 2,
            mRNA.
ACCESSION   NM_001437442 XM_039096772
VERSION     NM_001437442.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4856)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039096772.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.60330.1,
                                           SRR26643299.63451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000018.1  75871381-75871506   c
            127-247             JAXUCZ010000018.1  75862727-75862847   c
            248-337             JAXUCZ010000018.1  75857974-75858063   c
            338-4856            JAXUCZ010000018.1  75846860-75851378   c
FEATURES             Location/Qualifiers
     source          1..4856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..4856
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox 2"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
     exon            1..126
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     exon            127..247
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..3550
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox protein 2"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /protein_id="NP_001424371.1"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
                     /translation="MFQIPVQNLDNIRKVRKRVKGILVDIGLDSCKELLKDLKGFDPG
                     EKYFCNTSWGDVSLWEPSGKRAKYRTKPYCCSLCRYSTKVLTSLKNHLHRYHEEEADQ
                     ELMIPCPNCPFASQPKVVGKHFRMFHAPARKVQSYTVNILGEAKTSRSDVISFTCLKC
                     NFSNTLYYSMKKHVLVAHFNYLINSYFGLRTEETGEQPKASDPVSVDKALPFDKYYCK
                     KCSAIASSQDALMYHILTSDAHRDLENKLRSVISEHIKRTGFLKQMHIAPKPVTHIAL
                     PPNSSAPSIAAPPPCFQLALPQNSQSPGTVQSVTVAPGTSGSLTHSPPTTAQSHVALV
                     SSSLPVCQSSLTLQQSAPPPVFLSHSVPLSQPVSTSVLPLTQPLGPVNKSVGTSLLPV
                     NQAMCSVNQAVRPGVLPLPKPMGPINRPVGPGVLPVGPSVNSGVLQATSPGVISVGRA
                     VPSGVLPAGQVTPAGVIPGQTATSGVLPTGQVVQSSVLPVGQTAPSRVLPPGQTVPLR
                     VLPAGQVVPPGLLSPNQTVPSGVVPVNQGVNSGVLQLSQPVTPGVLPVGPPVRPGVLQ
                     LSPSVSTSILPVSQPVRAGTSQNTTFLTSGSILRQLIPTGKQVNGIPTYTLAPVSVTL
                     PVPSAGGLAAVGPPPQVPVQFLPSSSGTQMGSSLPSLPSPQVLVSPAPSVFVQATPPV
                     ADANQALRQAKQWKTCPVCNELFPANVYQVHMEVAHTQSEAKSSEKPEPERLAACAPF
                     LKWMREKTVRCLSCKCLVSQEELMHHLLMHGLGCLFCPCTFHDVRGLVEHSRTKHLGK
                     KRLSMDYSNRGFQLDLDANGNLLFPHLDFITILPREKLGEREVYLAILAGIHSKSLVP
                     VYVKVRPQPEVAPKIPNRQKLTCPFCFGTFMAADAYELHLKERHHVMPTVHTMLRSPA
                     FKCIHCCGVYTGNMTLGAIAVHLLRCRSAPKDSSSDLQAQPDFIESSELLMVNGEVIP
                     ESTFPLKRKLPEGHLGPEEQGDGDEPQLTVDTDASPGSEKGLSAVPLKRQKNESRTEG
                     SGASDDSLQVLALDPSKYGSRSYEEKKQFLRDYFHKRPYPSRKEVELLSSLLWVWKID
                     VASFFGKRRYICMKAIKSHKPSVLLGFDMSELKNVKHRLNFECESENL"
     misc_feature    140..3133
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    140..3133
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    3272..3433
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    3272..3433
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(3278..3289,3293..3295,3344..3346,3362..3364,
                     3401..3403,3407..3412,3419..3424,3428..3436,3440..3445)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(3278..3289,3293..3295,3344..3346,3362..3364,
                     3401..3403,3407..3412,3419..3424,3428..3436,3440..3445)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(3281..3283,3290..3292,3410..3412,3419..3424,
                     3431..3433)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    order(3281..3283,3290..3292,3410..3412,3419..3424,
                     3431..3433)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            248..337
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     exon            338..4856
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgccatc ttctctttct ggcgcgcggg aggagggacg ggcgcggggc gggggtcccg
       61 ccgcgtaggc ggaggacgcg gcggtgttgc gacggcggcg ggacgcggcg ctcctcgcgc
      121 cccgtggaaa atatcaaaaa tgtttcaaat tcctgtgcag aatcttgaca acatcagaaa
      181 ggtgcggaag agggtgaaag gcatccttgt ggacattgga cttgacagct gcaaggagct
      241 gctgaaggat cttaaaggct ttgatccggg agagaagtac ttttgtaata catcgtgggg
      301 agatgtttct ctttgggaac cttctggaaa gagagcgaaa tacagaacaa agccctactg
      361 ctgtagtctc tgcaggtact caacgaaggt gctcacctcc ctcaaaaatc acctgcaccg
      421 ataccacgaa gaggaggctg accaggagct catgatcccc tgccccaact gcccgtttgc
      481 ctctcagccc aaggttgtgg gcaagcactt cagaatgttc cacgcgcctg cgcggaaagt
      541 ccagagctac acagtgaaca tcctgggtga ggcgaagact tcaaggagtg atgtgataag
      601 cttcacatgt ttaaaatgta acttttcaaa cactctgtac tacagcatga agaagcatgt
      661 gctggtggcc cattttaatt acttaattaa ctcctacttt ggattgcgaa ctgaggaaac
      721 aggagaacaa ccgaaagcaa gtgatccagt ttctgtggat aaagccctgc catttgacaa
      781 gtactactgt aaaaaatgca gcgccatcgc cagtagtcag gatgccctga tgtatcacat
      841 tctgacatca gatgcacata gggacttgga gaataagctg aggtctgtta tctcagagca
      901 catcaagagg accgggtttc tgaagcaaat gcatattgct ccaaagccag tgacccacat
      961 agctttaccg ccaaacagca gtgctccgag cattgcagcc cctcctcctt gcttccagct
     1021 tgctttgcca cagaacagtc aaagtcccgg cactgtgcag tcagtgactg tggccccagg
     1081 cacttctggg agccttacac actcaccacc taccacggcc cagtctcatg tagctctggt
     1141 ctccagctct ttgcctgtgt gccagagtag cctcaccctg cagcagtccg ctcccccacc
     1201 tgtctttctc tctcacagtg tcccactgag tcagcccgtc agtacttctg tgctgcctct
     1261 cactcagcca cttgggcctg tgaataagtc tgttggaaca agcctcctcc ctgtgaacca
     1321 agccatgtgc tccgtgaacc aagctgtccg ccctggagtt ttacccctcc ctaagcccat
     1381 ggggcccata aacagacctg tgggccctgg tgtcttgcct gtgggtccct ctgttaactc
     1441 aggggttctc caggctacat ctcctggggt gatttctgta ggtcgagcag ttccatcagg
     1501 agtccttcct gcaggtcagg tgacccctgc tggtgtgatc cctgggcaga cagccacttc
     1561 cggggtctta cccactggcc aggtggtcca gtcgtcagtt ctccctgttg gccagacagc
     1621 gccatctcga gttctccctc ctggccagac agtgcccttg agggttctcc ctgcaggcca
     1681 ggtggtaccg cctgggctgc tttctccaaa ccaaactgtc ccctcgggag ttgtccctgt
     1741 gaatcaaggt gtgaactctg gtgttcttca gctcagtcag ccagtaacac caggagtcct
     1801 tcctgtgggc ccacccgtga ggcctggtgt tctgcagctc agtccgtctg tcagcaccag
     1861 catcctgccc gtgagccagc cggtgagagc tggaacgtcc caaaacacta ctttccttac
     1921 ttcaggttct attctcagac agctcattcc aactgggaaa caggtgaatg gaatccccac
     1981 ctatacgctg gccccagtgt ccgtcactct gccggtgccc tccgctggag gccttgcagc
     2041 tgttggaccg ccaccccagg tgccagtgca gttcctgccc tcaagctcgg gcacacagat
     2101 gggcagctcc ttgcccagcc tgccctcgcc acaggtgcta gtgagccctg cccctagcgt
     2161 gtttgttcag gctaccccgc ctgtggcaga tgcaaatcag gcactcagac aggccaagca
     2221 gtggaaaaca tgcccagttt gcaacgagct cttccctgcc aacgtctacc aggtccacat
     2281 ggaagtggct cacacgcaga gcgaggccaa gtccagtgag aagcctgagc ccgaaaggct
     2341 tgctgcatgc gccccatttc tgaagtggat gagagagaag acagtgcgct gcctctcttg
     2401 taagtgcctg gtctcgcagg aggagctgat gcaccatttg ctcatgcatg gcctggggtg
     2461 cctgttctgt ccatgcactt ttcatgatgt ccggggcctt gtggagcaca gcaggactaa
     2521 gcacctgggc aagaagagac tgtctatgga ttacagtaac agaggtttcc agctggactt
     2581 ggatgctaat gggaacctgc tgttccctca tctcgatttc atcaccatac tgccacgaga
     2641 gaaacttgga gagcgagaag tgtacctggc tatccttgct ggaatacact ccaagtcgtt
     2701 ggtccctgtg tacgttaagg tgaggcctca gcctgaggtt gcaccaaaga tacctaacag
     2761 acagaagctg acctgcccgt tctgttttgg cacattcatg gctgctgatg cctacgagct
     2821 gcatctgaag gagaggcacc atgtcatgcc cacagtccat acaatgctcc ggtctccggc
     2881 ctttaagtgc atccactgtt gtggggtcta cactggaaac atgaccttag gagccatcgc
     2941 tgtccatttg ctccgttgta gaagtgctcc aaaggacagc agctcagacc tgcaagccca
     3001 gccagatttt atcgagagca gtgaactgct gatggtcaat ggggaagtga tccccgagtc
     3061 cacctttcct ctgaagagaa agctgccaga aggccattta gggccagaag agcaggggga
     3121 cggggacgag ccccagctca cagtagacac cgatgcgagc ccaggttcag agaaagggct
     3181 gagtgctgtg cctttgaaga gacagaagaa tgagagcagg acagaggggt caggggccag
     3241 tgatgactcc ctgcaggtgt tggcgttaga ccccagtaag tatggaagtc gttcctatga
     3301 ggaaaagaaa cagttcctca gagactattt tcacaagaga ccatatccta gtcgaaaaga
     3361 agtggaacta ctgtcctcgc tcttgtgggt gtggaaaatc gacgtggcct cgttctttgg
     3421 gaaaaggagg tatatctgca tgaaagcaat aaaatcccac aagccctctg tacttctggg
     3481 ttttgatatg tctgagctta agaatgtcaa acacaggctg aactttgagt gtgagtcaga
     3541 aaacctgtag gagagtaagt ctgaagtctc ctgacttcca gcccttccca cctctcgctc
     3601 tgttgtaagt gtccgaggcc cttcaaggtg tcccaggtgc tcagaaagcc tgaaaaggaa
     3661 gcacacactg ccacagagga gctgttctcc gcagtttgcg ttgcggctgt ctgttttcct
     3721 tctgtcatgt aaattaaatc tttggtattc catgcacgcc ttgtttcccc acgagtgtca
     3781 gtgtcaatag caacaacctg gagtctgcag atacttggtt tttcatttta gagaatttct
     3841 gcttgtttga gaaacttgat taatagaaaa ttgaagcgtt gctccctctt agttcctagc
     3901 tgcagctagt gacagtgtgt gtttagagaa gcaagcactc tgatgtgtat gactccctaa
     3961 ggacatactt ttaagcatta acttctgctg attctgtgac cgacgtttgc ttaaggctac
     4021 aaatttgatt tacacctttt caagtgtccc ctgacagcta tttttttaat atcattattc
     4081 attaaaaaaa tcccagatgt tttccattta ttaaaatatc ctgactctga ggtctggtgt
     4141 gtagtaataa tcaagtgttg ctttataaat aaagactctg taggaacaga aatgctttat
     4201 ggtgcacact gtcttttgct gtgatgacaa gtcatttctc cattcaaagg taagacattt
     4261 ttagtgcctt tagactaaac tgaaaaccct gaggcccttc cttcttggaa ctgcttgtga
     4321 acagtgggaa ggaagggccc acgatagaca ttcgtgtctg gctcttgatt tagacacaac
     4381 ctgaggtgga attcgggttt cgggcataag gcgacaggca gacgagctgt gcctgtggtt
     4441 agagtagctg gggatgctgt gtgggagtca ggccttcaga tgaagggatg gtgaagcagt
     4501 gaatgctcac aatcctgccg atgccacatc ttgcttttcc ccctccctac gcgatcggta
     4561 atgtaaagca ccagacttgg taacgagggc cggccagctc tggtcccaat caccctcacc
     4621 cctccgggtg acgcaagcag gggttggccc tcagaacacg agcttgatga ccctgggaag
     4681 cgctgcagtg ttgctgtatg gcggttttaa aatacacttg catgtgatca ctgaagtgtt
     4741 gactcgaggc ggttatctgt gactcttgta aattcagagc ctgttggacc ttattttttt
     4801 tttttttaat tttcagagtg tctatttttg aattaaaatt tgttaaacca ctgaaa
//
LOCUS       NM_001108885            4416 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus kelch-like family member 14 (Klhl14), mRNA.
ACCESSION   NM_001108885 XM_001054994 XM_039096999 XM_344652
VERSION     NM_001108885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Giles,L.M., Li,L. and Chin,L.S.
  TITLE     Printor, a novel torsinA-interacting protein implicated in dystonia
            pathogenesis
  JOURNAL   J Biol Chem 284 (32), 21765-21775 (2009)
   PUBMED   19535332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Apr 2, 2025 this sequence version replaced
            XM_039096999.2, NM_001108885.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.34523.1,
                                           SRR26360176.1282008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1375              JAXUCZ010000018.1  13189760-13191134   c
            1376-1497           JAXUCZ010000018.1  13160431-13160552   c
            1498-1587           JAXUCZ010000018.1  13103812-13103901   c
            1588-1666           JAXUCZ010000018.1  13095693-13095771   c
            1667-1857           JAXUCZ010000018.1  13087718-13087908   c
            1858-2016           JAXUCZ010000018.1  13087479-13087637   c
            2017-2174           JAXUCZ010000018.1  13083668-13083825   c
            2175-4416           JAXUCZ010000018.1  13079161-13081402   c
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..4416
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="kelch-like family member 14"
                     /db_xref="GeneID:364823"
                     /db_xref="RGD:1566178"
     exon            1..1375
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    243..245
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="upstream in-frame stop codon"
     CDS             423..2315
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="kelch-like 14"
                     /codon_start=1
                     /product="kelch-like protein 14"
                     /protein_id="NP_001102355.1"
                     /db_xref="GeneID:364823"
                     /db_xref="RGD:1566178"
                     /translation="MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQF
                     HCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQQQQPQQQPSQQQQQPP
                     QEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL
                     SVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLL
                     NFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPEL
                     VERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPP
                     GPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHS
                     TNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDT
                     NEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNT
                     KRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPG
                     CAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACATVILPA
                     CVPYNK"
     misc_feature    423..992
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 14 (KLHL14); Region: BTB_POZ_KLHL14_printor;
                     cd18243"
                     /db_xref="CDD:349552"
     misc_feature    423..992
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 14 (KLHL14); Region: BTB_POZ_KLHL14_printor;
                     cd18243"
                     /db_xref="CDD:349552"
     misc_feature    969..1274
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 14 (KLHL14); Region: BACK_KLHL14;
                     cd18453"
                     /db_xref="CDD:350528"
     misc_feature    969..1274
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 14 (KLHL14); Region: BACK_KLHL14;
                     cd18453"
                     /db_xref="CDD:350528"
     misc_feature    1398..2159
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1398..2159
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; Region: NanM; COG3055"
                     /db_xref="CDD:442289"
     misc_feature    1515..1658
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1515..1658
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1668..1802
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1668..1802
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1809..1946
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    1809..1946
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2106..2234
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:396078"
     misc_feature    2106..2234
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="Kelch motif; Region: Kelch_1; pfam01344"
                     /db_xref="CDD:396078"
     misc_feature    2106..2234
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     misc_feature    2106..2234
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /note="KELCH repeat [structural motif]; Region: KELCH
                     repeat"
                     /db_xref="CDD:276965"
     exon            1376..1497
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1587
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1666
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1857
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2016
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2174
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..4416
                     /gene="Klhl14"
                     /gene_synonym="RGD1566178"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcatccag ctgggcatgg actcgagccc acgaggtgtc acggcctcag cctccacttt
       61 tgccgccgct gctgtcaccg ccgtcgctgc caagagagga gcctgggtgc ttttaggaaa
      121 gtgaggggcg aagagtgtaa gaggtagcaa ggagcagaac cggagtcccg accccagacg
      181 aggacccttc aggaggcgct caggaccggg cgccttcaca cctccctctt aggctcgcat
      241 cctaagcgca cagggaggga gccaagcggg gccttgactg ttgttcctct ctcccctcca
      301 cacccttccc caccccggcc acaccccacc ccccttcacc tccctgctcc ccctcccatc
      361 ccccacccct gtctgccagg ttggaggagg gtttaaagcc aggtgcgcag agtcagctcg
      421 ccatgtccag atccggggac aggacctcca ccttcgaccc cagccacagt gacaacctgc
      481 tgcacggtct caacctgctg tggaggaagc agctattttg cgacgtgacc ctgacagccc
      541 aaggccaaca gttccactgc cacaaggccg tgctggcctc ctgctcgcag tacttccgat
      601 cactcttctc cagccacccc cctctcgggg gaggggtcgg cggccaggac ggcctggggg
      661 cccccaagga ccagcagcag cagcagcagc cgcagcagca gccttcacag cagcagcagc
      721 agccaccaca ggaggagccc gggactcctt cctcctcccc cgacgacaag ctgctgacca
      781 gtccccgagc catcaacaac ctagtgctgc agggctgctc gtccatcggg ctgcgcctag
      841 tgcttgaata cctctacacg gccaacgtga ccctgtccct ggacaccgtg gaggaggtgc
      901 tgtcggtcag caaaatcctg cacattcctc aggtcaccaa gctctgcgtt cagttcctca
      961 acgaccagat ctcggtgcag aactacaagc aggtgtgcaa gatcgccgca ctgcacggcc
     1021 tggaggagac caagaagctg gccaacaagt acctggtgga ggatgtgctg ttgcttaact
     1081 tcgaggagat gcgtgccctg ctggactcgc tgccgccccc cgtggagtcg gagctggcac
     1141 ttttccagat gtccgtgctg tggctggagc acgaccgtga gacccgcatg cagtacgcgc
     1201 ccgacctcat gaagcgcctt cgctttgcgc tcatccccgc cccggagctg gtggagcggg
     1261 tccagtcggt ggatttcatg cgcaccgacc cggtctgcca gaagctgctg ctggacgcca
     1321 tgaactacca cctgatgccc ttcaggcagc actgcaggca gagcctggcc agcagaattc
     1381 gctctaacaa gaaaatgctg ctgttggttg gagggttgcc tcctggacca gaccggctcc
     1441 ccagcaatct ggttcagtat tatgacgacg aaaagaagac atggaaaata ctcacaatta
     1501 tgccttacaa cagtgcccac cactgcgttg tagaggtaga aaacttcctg ttcgtgttgg
     1561 gtggagagga ccagtggaac ccaaatggaa aacatagtac aaattttgtc agccgatatg
     1621 atccccgatt taatagttgg attcaacttc cacccatgca agaaagaaga gccagtttct
     1681 acgcatgtcg cttggacaag catttatatg tgatcggcgg gaggaacgaa actggctacc
     1741 tgtccagtgt ggagtgctac aacctggaca caaacgagtg gcgctatgtg tcgtctctgc
     1801 ctcagccgct ggcagcccac gcaggagcag tgcacaatgg gaaaatatac atttcagggg
     1861 gagtgcacaa cggagagtat gtcccgtggt tgtattgtta tgacccggtc atggatgtct
     1921 gggcccgcaa acaagacatg aacacgaagc gtgccatcca cactctggct gtgatgaacg
     1981 atcgcttgta tgcaattgga gggaatcatt tgaaaggctt ctcccaccta gacgtcatgc
     2041 ttgtggagtg ctatgaccca aaaggtgacc agtggaatat actccaaaca cccatcctgg
     2101 agggtcgaag tgggcctggc tgtgcggtgc tcgatgacag catttatcta gttggaggct
     2161 acagctggag tatgggtgcc tacaagtcct ctacaatctg ctattgtcca gaaaaaggaa
     2221 cctggacaga actcgaaggc gatgtggctg aacctctggc aggcccagcc tgtgcgacag
     2281 tcattctacc agcctgtgtg ccctacaaca aatgacagca ggaaagcctg gcatagtgcc
     2341 acacctagaa tgcagggaca ggcggtgtgc tgtcctgcgt gaaccatgca ttccaatggt
     2401 acaactgccc taacctttgg tttctgatga cttaaaagtg acttgcagaa gaaagagacc
     2461 cggccttgag cagagactgt tgtttgcaac ccagatgaca ctcaacttgt ggtgacagac
     2521 tcttccatat caggccggtt tgaacttgtt ccacctttac gcaaactcac gtggagctga
     2581 actttcaaaa aggaaaagat aagccacgga agcctggccc cagagaccta agatccatat
     2641 tgttgcattg tttcctaact gcatgtgata gactcggaca tttggcaaat attttgtaca
     2701 tgaatgattc aaagtccaac ccacggaaat ggtcaccctg tattccagaa agcgtcactt
     2761 gattctgtat tggtaaatgc ttggcttctt caccaactcc ataggtagca aaggaaaacc
     2821 acagaagaag gaagacaggc atctttgttt ccacacagtc atattctcta tcccttacag
     2881 cttaccatgg gatcgggaaa aagtgagttg gtgtctttgg taattgttct ctgctagaga
     2941 acaattaatt gtgtgtcttt gatactcctt gaaaattaaa actaagtgcg ctctgttgct
     3001 tttcagctcc cagaaactca tgcttcctca tttcttatgg gcatcttaag tagtgaacat
     3061 aggacaattt gcctcaagat agaagaccaa caactccatc atgaactatc tcagaaactc
     3121 tgttagatag aaatttgttc ccaatctaat ccataataaa aactgacaaa tcactttcag
     3181 aaattcaggt acacaaggca aactttctct caagtacaac ccaattatct ttctgattct
     3241 taaaacacat gacttccagc tgaagagatg gctcagtggt tcaaagcact tgcttctcag
     3301 gcagaggacc tgggtttggc tctcagcacc catgtggcga cttaccacca tccgtaactc
     3361 cagatccagg gcacccgtac atatgcagtg cacttacaaa cttgtaaaca aaacacttgt
     3421 acacgtgaaa taaaaataaa taactctttt aaaataatta ttttttaaaa aatgaacttg
     3481 caaactcata gttcctaatg gcccacttcc tcacctctgt ctgtctggca ccagattccc
     3541 gattctcatt cttcttccac ttaccccatt gttttttatc actggagatg cctggacttg
     3601 gtcaagagag taacttattc ttgttttgag gaactgaaaa cataaaagga tcaggagagc
     3661 atgacacggt ctctttgtgg ccaatcagaa aagcaaaact aagaaaaaca tgaattagat
     3721 tttcaagctc atctgagttt gaccaacacc gttaggcact tccaagcacc taaatatttt
     3781 tttaaatcac aaagaaatgt tgaccacctt caacaaatgt gatgttaaaa ataccaagta
     3841 ggggtagcca cagataagaa caaatgcttt catgggaagc ttccacaatc acctcaaggt
     3901 ggctgggcgt accagaatcc aacaacgttt ctacagaaaa gtgcaatctt tgttgttttt
     3961 gtatttattt gtatgttcag atccaaagga tctgttgtaa aaatatatat gtgaatatat
     4021 atacataacc agtgcaatca gcttccattt cctttttctt gaaaacacac gaatatatag
     4081 aaagaaagac aataagaaca tgagaaacgc ccaccggcat cccagagaga gcgagctgtt
     4141 tccaaaactg tattctcagc tgttacaagt cgctgtttat acaagggtat cggcttttcc
     4201 ttagacttgt tccttgcttt attttttatc actaaccaaa ttaaataaaa gcatttatga
     4261 gaactctaaa gctttctgta tttcagagag atgcaaactt ctagagtaaa aagtgaataa
     4321 aaagtcacag aggatgtaaa ttttgtacag gactaggatg taaatgaagc ttgcttggaa
     4381 ggggaaaagt ttaaataaaa ctttatgtac aaattc
//
LOCUS       NM_001191667            3698 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus BICD family like cargo adaptor 1 (Bicdl1), mRNA.
ACCESSION   NM_001191667 XM_222240
VERSION     NM_001191667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Schlager,M.A., Kapitein,L.C., Grigoriev,I., Burzynski,G.M.,
            Wulf,P.S., Keijzer,N., de Graaff,E., Fukuda,M., Shepherd,I.T.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     Pericentrosomal targeting of Rab6 secretory vesicles by
            Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
  JOURNAL   EMBO J 29 (10), 1637-1651 (2010)
   PUBMED   20360680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001191667.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.551204.1,
                                           SRR22582424.85624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1124              JAXUCZ010000012.1  46538378-46539501
            1125-1340           JAXUCZ010000012.1  46545477-46545692
            1341-1457           JAXUCZ010000012.1  46601587-46601703
            1458-1604           JAXUCZ010000012.1  46604517-46604663
            1605-1784           JAXUCZ010000012.1  46611113-46611292
            1785-2003           JAXUCZ010000012.1  46612023-46612241
            2004-2134           JAXUCZ010000012.1  46618795-46618925
            2135-2255           JAXUCZ010000012.1  46622903-46623023
            2256-3698           JAXUCZ010000012.1  46625434-46626876
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3698
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /note="BICD family like cargo adaptor 1"
                     /db_xref="GeneID:304537"
                     /db_xref="RGD:1310292"
     exon            1..1124
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    258..260
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /note="upstream in-frame stop codon"
     CDS             693..2414
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /note="bicaudal D-related protein 1; coiled-coil domain
                     containing 64"
                     /codon_start=1
                     /product="BICD family-like cargo adapter 1"
                     /protein_id="NP_001178596.1"
                     /db_xref="GeneID:304537"
                     /db_xref="RGD:1310292"
                     /translation="MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPAAAAALV
                     SFPGGPGELELALEEELALLAAGERPSDLGEHPQAEPGSPAEGHGPPPPPTQDPELLS
                     VIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENR
                     EGEWEGRVSELETDVKQLQDELERQQVHLREADREKTRAVQELSEQNQRLLDQLSRAS
                     EVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEE
                     NDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQVKVEELTEERS
                     LQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSA
                     VSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKE
                     ERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKKAVELELAKCKMDMMSLNSQLLDAIQ
                     QKLNLSQQLEAWQDDMHRVIDRQLMDTHLKEQSRPAAAFPRGHGVGRGQEPSTDGKRL
                     FSFFRKI"
     misc_feature    <1002..2129
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1002..2129
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            1125..1340
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1457
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1604
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1784
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2003
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2134
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2255
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..3698
                     /gene="Bicdl1"
                     /gene_synonym="Ccdc64; RGD1310292"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggggcg ggcgcctcgg cccggtgagc tgcggagccg ggaaggctag aaggagggct
       61 ccggggctgc gcggctaacg atgtcgagcc gccgcctcgg cccctgccgc agcagcagca
      121 gcagcagccg ccgccgccgc cgctgctgcc gccaagcctg gggacatgga gcgcggctgc
      181 aaggagcggc cgacggcagc agcagcagca gcagcaacag cgagcgtcgc agcgacagcg
      241 gagcgcaacc ctccccgtaa ggcgccggcc ggccggcggc ggcggcggcg gcggcggcag
      301 cagcagcggc ggcagcaaca gggcggctga aacccgggcc gcggcggcgg cggcgaccct
      361 cagcgcggcc tcccctccgg ctccgcgccc ccctcggctc tccccttcct cggccgctct
      421 tgcccacccc ctcgatcgcg tcccgggggc gcgcgccagc agctgagccc gggggcgggg
      481 gcgcgtgccg ccggcgcggg ggaggggcgg gccgcccgcg cgcgccgcgc ctcgccgcgc
      541 cgcgcccagg gctcgcgggg acccgggggg cgcgtgccgc ggcgcgaggc gaagagcggg
      601 gcggcgcggc ggggcccctc cccctcccac ccccctgcag cctggcgcgc gccggccggg
      661 ccgcaccgct gcgggctcgg cgcgcgcggg ccatgtccgc cttctgcctg ggcttggccg
      721 gccgagcttc agcacccgcc gagccggaca gcgcctgctg catggagctg cccgctgggg
      781 ccggggacgc agtccggagt cccgccgccg ccgccgccct tgtctctttc cccgggggtc
      841 ccggggaact ggaactggcc ttagaggagg agctggcgtt gctggcggcc ggggagcggc
      901 cgtccgacct cggggagcat cctcaggcgg agccggggtc tccggctgag gggcacggac
      961 cgccgccgcc gcctacccag gatcccgagc tgctgtcggt gatcaggcag aaggagaagg
     1021 atctggtgtt ggcggcccgg ctaggcaagg cgctgctcga gaggaaccag gacatgagcc
     1081 ggcagtacga gcagatgcac aaggagctga cggacaagct ggagcactta gagcaagaga
     1141 agcatgagct gagaaggcgg tttgagaacc gagaagggga gtgggaagga cgagtgtccg
     1201 agctggagac ggacgtgaag cagctacagg acgagctgga gaggcagcag gtccatcttc
     1261 gggaagcgga tcgagaaaaa actcgcgctg tccaggaact gtcagaacag aaccaaaggc
     1321 tactggatca actgagcagg gcatctgaag ttgagagaca gctatccatg caggtccatg
     1381 ctctcaaaga agactttcgg gagaaaaatt catccaccaa ccagcatatc atccggctag
     1441 agagccttca ggccgagatc aagatgctgt cggaccgaaa acgggagctg gagcatcggc
     1501 tcagtgccac cctagaggag aatgacctgc ttcaagggac tgtggaggag ctacaggacc
     1561 gggtgctgat cctagaaagg cagggccatg acaaagacct gcagctgcac cagagccagc
     1621 tggagctcca ggaggtccgt ctgtcctacc ggcagctgca ggtcaaagtg gaggagctga
     1681 cggaggagag gagcctgcag agctcggcgg ccaccagcac gtccctgctg tcagagatcg
     1741 agcagagcat ggaggctgag gagctggagc aggagagaga gcagctgagg ctgcagctct
     1801 gggaagccta ctgccaggtt cgctatctgt gctcacacct tcgagggaat gacagcgccg
     1861 attcagccgt gtccacagac tcctccatgg atgagtcctc agagacctca tccgccaagg
     1921 acgtgcctgc cggcagcctg cgcaccgccc tcaacgatct caagaggctg atccagagca
     1981 tcgtggacgg cgtggagccc acggtcacgc tgctgagtgt ggagatgacc gccctgaagg
     2041 aagaaaggga cagactcaga gtgacatctg aggacaagga gcccaaggag cagcttcaga
     2101 aggccatcag ggaccgggac gaggccattg caaagaagaa ggctgtggag ctggaactcg
     2161 ccaagtgcaa gatggacatg atgtctctca acagccagct actggacgcc attcagcaga
     2221 aactgaacct ctcccagcag cttgaggcct ggcaggatga catgcacagg gtcattgaca
     2281 ggcagctgat ggacacgcac ctgaaggaac agagccggcc tgctgctgcc ttccctaggg
     2341 gccacggcgt agggcggggg caggaaccca gcacagacgg caaacggctc ttctccttct
     2401 tcaggaaaat ttaagtgggg aggagtctgg ccattgagat ggggggacta gcagcacctg
     2461 aaaagggtcc cctttagctg gagctgggca gctacactgc ccgcccacct gccctggggc
     2521 ccagttagct ccagagagct cactccctat gtcagcgtaa tggaggctga gaggtagggc
     2581 ctgctctgtc ctctgaaggc tgcccacccc ccacacacac aagggacagg aatgtatctt
     2641 gtccccactg cccaagccaa gcctcagcct gggcttgccc aggatcctgt tagtgagcag
     2701 ggctcagcca cttcccatgc agcccactgc tgggctctgc cacccaggcc cagctgagca
     2761 cagcccaccc tataaaggct ctgctgcctc cttggttttg aacatgggga acagattggg
     2821 gcctcctgtg catgcctcag gaggcctaag cctccgctcc tgctccagcc actggcctgg
     2881 agtgtgggga gacacagccc tcacccaagt gcatgcacct ctgctggagc ccctgtacgg
     2941 caggcggctc agcctacggc tgtgaggcct aagaactggg tgtacccaag ccctgttgag
     3001 gccgtcctgc accccaggga aggtcctgtc ttctggctgc caccactcct cagcttcctc
     3061 cagtgcagtc cttagcccta gggaggcctg ggccaggctg tgtcccattg gccctgtagg
     3121 ctttagcctt ccagactttt cccccatcac gggataggac taggagggca cttgtcttcc
     3181 acagctccct cccacctcaa atgcaacttc ttggccaagc caagcaagtt caggccacaa
     3241 gagtggcctt ggaggggcct ggttttacca ccctcacact gaaggcagcg tgggtgccac
     3301 agggtagatg gggcaaggct gctgggagcc tccagatact gcccaccagg tctctaaggg
     3361 acaaaggcct tcagcctgct gcttctgctc cttccgcagc agccacccca tctcagccga
     3421 ggccccagct caaggctctg tggggccggc ctgcactgct ctccactcac tgagcctcct
     3481 ccctcgacag ggacaagcac agcagggctg agcgacagaa tgtacttaca gacatgtaca
     3541 taccacagtg ctgtaatttt gtatgtagca attgtgtaaa tacacgtatg gattttataa
     3601 tacacacata aatctataaa ggcatatttt tagaaaaaca gcgcaccact gcttcttttg
     3661 gaaatagtct gaataagaat aaaatgagtt tctacaga
//
LOCUS       NM_001009492            2026 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus 2'-5' oligoadenylate synthetase 1E (Oas1e), mRNA.
ACCESSION   NM_001009492 XM_579293
VERSION     NM_001009492.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 4, 2025 this sequence version replaced NM_001009492.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY196698.1, SRR26643429.43391.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000012.1  41396000-41396078
            80-543              JAXUCZ010000012.1  41410728-41411191
            544-832             JAXUCZ010000012.1  41412086-41412374
            833-1029            JAXUCZ010000012.1  41414228-41414424
            1030-1262           JAXUCZ010000012.1  41417338-41417570
            1263-1416           JAXUCZ010000012.1  41418205-41418358
            1417-2026           JAXUCZ010000012.1  41419318-41419927
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2026
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="2'-5' oligoadenylate synthetase 1E"
                     /db_xref="GeneID:494201"
                     /db_xref="RGD:1359611"
     exon            1..79
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     exon            80..543
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    262..264
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="upstream in-frame stop codon"
     CDS             361..1446
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="2'-5' oligoadenylate synthetase 1C; 2 ' -5 '
                     oligoadenylate synthetase 1C"
                     /codon_start=1
                     /product="2'-5' oligoadenylate synthetase 1E"
                     /protein_id="NP_001009492.1"
                     /db_xref="GeneID:494201"
                     /db_xref="RGD:1359611"
                     /translation="MSRRLARTPIWRLDRFIEDHLLPDTTFLTEVRADIDSICAFLTE
                     RCFQGATHPVRVSRIVKGGWFNKYTMLKGRSEATLVVFLNNLTCFEDQLKRREEFTEE
                     IWKHLCQLQQEKQFKLNFEVQSTEQPDSRTLSIKLSSPQLQQEVEFDVQPAYDVLYEL
                     RDKDDFNPDNYREIYARLIRESTTLEMEGEFSVCFTDLHQNFLKYRAPKLWNIIRLVK
                     HWYQLCKKRLKYPLPPQYALELLTVYAWERGLEDRPALHTGHCFRSVLDLITEYKKLR
                     IYWTWCYEFKKETFDYLSRQIKKDRPVILDPADPTRNVAGSNIQSWHVLAKEAAVWAR
                     SSFFRNSDMTFVNGWKVSAQKQECVYQ"
     misc_feature    439..891
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    439..891
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="Nucleotidyltransferase (NT) domain of
                     2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I
                     CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase;
                     cd05400"
                     /db_xref="CDD:143390"
     misc_feature    order(544..552,559..561,565..573,586..588,592..594,
                     742..747,754..756,805..807,847..849,859..861,868..870)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(544..552,559..561,565..573,586..588,592..594,
                     742..747,754..756,805..807,847..849,859..861,868..870)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="active site"
                     /db_xref="CDD:143390"
     misc_feature    order(547..552,586..588,592..594,745..747,847..849,
                     859..861,868..870)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(547..552,586..588,592..594,745..747,847..849,
                     859..861,868..870)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="NTP binding site [chemical binding]; other site"
                     /db_xref="CDD:143390"
     misc_feature    order(586..588,592..594,805..807)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    order(586..588,592..594,805..807)
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="metal binding triad [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:143390"
     misc_feature    856..1413
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     misc_feature    856..1413
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /note="2'-5'-oligoadenylate synthetase 1, domain 2,
                     C-terminus; Region: OAS1_C; pfam10421"
                     /db_xref="CDD:463087"
     exon            544..832
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1029
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1262
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1416
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..2026
                     /gene="Oas1e"
                     /gene_synonym="Oas1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaaccttc caagggaaga aaacctaaga gacctgatca ggctttctgg gggatttttc
       61 tgggaaaagc tgttacaaat aacaattcaa gatcaagaag gaaaaacaac agaaactatc
      121 tttttgatgc ttcttgcctc ctggtccaca gccaactatg aggagggttt gacaatctaa
      181 agaaatgcca gcagataatc aaaccccaga gtgtcaggga gcccaggagc caggggaggc
      241 aggtgtagag tctgatttgc atagctccgc cctttctggg aaagaggaac caggtatgga
      301 tataaggggc agctgactcc tgaggcaagg ctgcagtcag cacacattcc tgacctcagg
      361 atgtcgaggc gactcgccag aaccccaatc tggaggctgg acagattcat agaggatcac
      421 ctccttcctg acaccacctt ccttactgag gtcagagcag acattgactc tatatgtgct
      481 ttcctgactg agagatgctt ccaaggtgcc acccaccctg tgagggtctc taggattgtg
      541 aagggtggct ggttcaataa atacaccatg cttaagggaa ggtcagaggc caccctggtg
      601 gtgttcctta acaatctcac ctgctttgag gatcagttaa agcgacgaga agagttcact
      661 gaggaaattt ggaaacacct gtgccagttg cagcaagaga aacagtttaa actgaatttt
      721 gaggtccaga gcacagaaca gcccgactcc aggactctga gcatcaagct gagctcgccc
      781 cagctccagc aggaggtgga gtttgatgtg cagccagcct atgatgtcct gtatgagcta
      841 agagacaagg acgactttaa cccggataac tacagggaaa tctatgcccg ccttatccgt
      901 gagagcacca ccctggagat ggagggcgag ttctccgtct gcttcacgga ccttcatcag
      961 aacttcctga agtatcgtgc accaaagctg tggaatatca tccgtctggt caagcactgg
     1021 tatcaactgt gtaagaagag gctgaagtat ccgctgcccc cacagtacgc cctggagctg
     1081 ctcacggtct atgcctggga gcgtgggctg gaagaccgcc ctgcactaca tacaggccac
     1141 tgtttccgaa gtgtcttaga tctgatcaca gagtacaaga agcttcgaat ctactggaca
     1201 tggtgctatg aattcaaaaa agagaccttt gactatctga gcagacagat aaaaaaagac
     1261 aggcccgtga tcctggaccc tgctgaccca acaaggaacg tggctggttc aaacatccaa
     1321 tcctggcacg tgctggcaaa agaagctgcg gtctgggcgc ggtcgtcttt ctttaggaac
     1381 agtgatatga cctttgtcaa tggctggaaa gtgtcggcac agaaacaaga atgtgtctac
     1441 cagtgagcac cacagccctt gcccaggagg ctctggagtc agggccatgt gctcctctgc
     1501 tgcaagacct tgtcctggag agaacagttt ggcgcaccag ggtccagtga ggggcatcca
     1561 acctgtgatc agactccagg cttctattcc gtcctgccca tgggacagcc ttcctcacag
     1621 cctgcttcac ctgccttatc ccccacagtg ttctctggga gtcagactcc gaaggaaaga
     1681 gaagagctca aacgtggctt ctgtctgtcc acctgtgggg aggctctgtc cacaaacatg
     1741 tctgatcatg aacaatcgac cacagcaatc cctgagggag tgtgcactcg gaggggtgag
     1801 tcctcagccc acataggaac ggctcagcag aggagcgtgg cccgggaacg ctggggatct
     1861 ggccagtgtg catcgaggtg cactgttggg caaagtgtga gctggggtta cggcagtgca
     1921 gggaaataaa attgtatgca ctttaaaact taggacctta aaacttagat gtgtgtgcgt
     1981 gtgaggatga gatttgaagc cctgaattaa agtaaaatgc aaagaa
//
LOCUS       NM_001437467            2587 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus GRAM domain containing 2B (Gramd2b), transcript
            variant 2, mRNA.
ACCESSION   NM_001437467 XM_006254748
VERSION     NM_001437467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 3, 2025 this sequence version replaced XM_006254748.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.2838225.1,
                                           SRR26643299.62840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000018.1  52112803-52113013
            212-331             JAXUCZ010000018.1  52149457-52149576
            332-443             JAXUCZ010000018.1  52153538-52153649
            444-510             JAXUCZ010000018.1  52155530-52155596
            511-614             JAXUCZ010000018.1  52157431-52157534
            615-710             JAXUCZ010000018.1  52160835-52160930
            711-782             JAXUCZ010000018.1  52163592-52163663
            783-863             JAXUCZ010000018.1  52163752-52163832
            864-975             JAXUCZ010000018.1  52167125-52167236
            976-1098            JAXUCZ010000018.1  52167894-52168016
            1099-1186           JAXUCZ010000018.1  52169053-52169140
            1187-1291           JAXUCZ010000018.1  52170384-52170488
            1292-1385           JAXUCZ010000018.1  52175620-52175713
            1386-2587           JAXUCZ010000018.1  52178855-52180056
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11-q12.1"
     gene            1..2587
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain containing 2B"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
     exon            1..211
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1427
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="isoform 2 is encoded by transcript variant 2; GRAM
                     domain-containing protein 3; GRAM domain-containing
                     protein 2B; GRAM domain containing 3"
                     /codon_start=1
                     /product="GRAM domain-containing protein 2B isoform 2"
                     /protein_id="NP_001424396.1"
                     /db_xref="GeneID:307288"
                     /db_xref="RGD:1311016"
                     /translation="MTELQQEVEDAKPAKVLTKREGKVGPAHSEAENGVEDRKRFSKS
                     PTAQSPTSSVEAESPDQKRSLGLWSKSSFDGSNLLSDKNDCKTESKADSKTERKKSSS
                     SSQYKANMHFHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSENWICFHSKVFGKD
                     TKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLLKSICGHLE
                     NTSVGNSPNPSSAENSFRADRPSSLRLDFNDEFSDLDGVVQQRRQDLEGYSSSGSQTP
                     ESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGKAKILPAHGQSETIGILHK
                     MESRKCPTLRHILIFYAIIVCALIISTFYMRYRINTLEERLGSLTSIMDPHSTEQTAP
                     SSLGSQVQLNVEVLCQELTANIVTLEKIQNNLQKLLENGD"
     misc_feature    492..770
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     misc_feature    492..770
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_GRAMDC; cd13220"
                     /db_xref="CDD:275406"
     exon            212..331
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            332..443
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            444..510
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            511..614
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            615..710
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            711..782
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            783..863
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            864..975
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1098
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1186
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1291
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1385
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2587
                     /gene="Gramd2b"
                     /gene_synonym="Gramd3; RGD1311016"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgtgtcca tgttggcggc ccgggagctc agctgcctgg atgcgcagcg ttagggtgca
       61 ggagaacagg gagccgggag ccccgaatag ggagccgagt cctggggtac tcccgggacg
      121 cggccctgat gactgagctc cagcaagagg tggaggacgc caagccagcc aaagtgctca
      181 ccaagagaga aggcaaagtt ggcccggccc actcagaggc tgagaatggc gtggaagaca
      241 gaaagaggtt cagcaagtcg ccaacagccc aatctcctac ctcatctgtg gaggccgagt
      301 ccccggacca gaagagaagc ctcggtctgt ggtcaaaatc cagttttgat ggctccaatt
      361 tgttgagcga taagaatgac tgtaaaaccg aaagcaaggc tgactctaag accgaaagaa
      421 aaaagtcttc ctcctccagc cagtacaagg caaacatgca ctttcacaag ctattccttg
      481 atgtcccaac cgaggagccc ctgagacaaa gctttacctg tgctctccag aaagaaattc
      541 tgtaccaagg aaagctcttt gtgtcggaaa actggatttg ttttcattcc aaggtctttg
      601 gaaaagacac taagatctct atcccagcct tttcggtaac cttgatcaag aaaaccaaaa
      661 ctgcccttct ggtgccaaat gccctgatca tagcgacggt cacagacagg tacatattcg
      721 tttccttgct gtccagagac tcaacctaca aactgctaaa atctatttgc ggacacttag
      781 agaacacaag tgtcgggaac agtcccaacc catcttctgc tgaaaatagc ttccgggcag
      841 atcgcccttc ctctctgcgt ctggatttca atgatgaatt ctcagacctg gacggagtgg
      901 ttcaacaacg aaggcaagac ttggaaggat acagcagttc cggctcccag actccagaat
      961 ctgagaactc tcgagacttc catgtgaccg aatctcagac agttctgaat gtcacaaagg
     1021 gagaaacaaa accacctcgg acagatgccc acgggagcag agcgcctgat ggaaaagcca
     1081 agatcctgcc tgcccatggt caatcggaaa ctattgggat tttacataaa atggagtctc
     1141 ggaagtgtcc aactctccgt catatcctta tattctacgc cattattgtc tgtgcgttga
     1201 tcatctccac cttctacatg agatacagga ttaacactct ggaggagcgc ctggggtcct
     1261 tgacgtccat catggatccc cacagtactg agcagacagc cccctccagc ctaggatcac
     1321 aagtacagtt aaatgtggag gtcctctgcc aagaacttac agctaacata gtgacattag
     1381 aaaagataca aaacaactta cagaagctgc ttgagaatgg ggactgagtg accagctgct
     1441 ggggccaaca taatacctca cgttctccct tgaagaaggt gcttctcgag agtctgttgt
     1501 gcgccccctg ctggccagag gcgcaagatg ctgagaatcc agatgtgttt gcgcttggag
     1561 gtctccagct caggaagggg ggaggggaat gagtttgctt tcgtgcaata aaagttgacc
     1621 ttgtctctgc tgctgcctga agataacaga cccatctcgg gaggtgagca aggtcctgga
     1681 ggacacctgt aacactcggg ttatggtaac atcagtaaac acagcactcc acgcttgtca
     1741 gctctttctc agccattgct gccttcaccc acaccaatca gccttcagac ctaaggggag
     1801 gtacactgta taccaccaaa ctcaaaatgg tcctttagag aattagtcac gagcctccaa
     1861 caaggtggtg aatctctctc aatgagcagg cttgcttctg acaccttcac gtttgtggtt
     1921 ttgtttttgt tttcgtgttc ccttctactc ttatgttctg gtttctttca tctgtgcctt
     1981 taaattttcc aattcggttg ggtgagcatg tccggtaaag tgaattaaat gtcccatctg
     2041 tgttgtgctg tcttgcgcct gtgactagta cgtaattgga gtgattctcc ccaacctccc
     2101 gtcaggaatc tttgaggtgt gacattgaaa tactaaatca gattcgctct gaaaccaaaa
     2161 ctaatctttc agcccaaagc tgtcctagaa atgtaatatg ggaaggaaag ccccgttcct
     2221 ggggttgtaa gtgcagtggg agctttgaag caggatgtct gtgttggact ctaaaaccca
     2281 tttcagcatg gtaattggat gtctttctcc tacaataaag cgtaagtggt ggtctgctaa
     2341 ctttacttac agtatgggtt ggctggtttt tattaataat gatttagggt accataagat
     2401 ctgtaagtat aaaacattct atctgcgatg cattttataa tcatttctat gaaatgtatt
     2461 ttgtttaatc agagaagcta ataagcggat tggccgtgtc atgtgtattg gtctgcgtat
     2521 tgggtaactg tgcctggtgc acccccggct tttaataaat actcattgcc taaggcaccc
     2581 tagttaa
//
LOCUS       NM_012647               8554 bp    mRNA    linear   ROD 08-APR-2025
DEFINITION  Rattus norvegicus sodium voltage-gated channel alpha subunit 2
            (Scn2a), mRNA.
ACCESSION   NM_012647
VERSION     NM_012647.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8554)
  AUTHORS   van Cann,M., Kuzmenkov,A., Isensee,J., Andreev-Andrievskiy,A.,
            Peigneur,S., Khusainov,G., Berkut,A., Tytgat,J., Vassilevski,A. and
            Hucho,T.
  TITLE     Scorpion toxin MeuNaTxalpha-1 sensitizes primary nociceptors by
            selective modulation of voltage-gated sodium channels
  JOURNAL   FEBS J 288 (7), 2418-2435 (2021)
   PUBMED   33051988
  REMARK    GeneRIF: Scorpion toxin MeuNaTxalpha-1 sensitizes primary
            nociceptors by selective modulation of voltage-gated sodium
            channels.
REFERENCE   2  (bases 1 to 8554)
  AUTHORS   Middleton,S.J., Kneller,E.M., Chen,S., Ogiwara,I., Montal,M.,
            Yamakawa,K. and McHugh,T.J.
  TITLE     Altered hippocampal replay is associated with memory impairment in
            mice heterozygous for the Scn2a gene
  JOURNAL   Nat Neurosci 21 (7), 996-1003 (2018)
   PUBMED   29867081
REFERENCE   3  (bases 1 to 8554)
  AUTHORS   Johnson,K.W., Herold,K.F., Milner,T.A., Hemmings,H.C. Jr. and
            Platholi,J.
  TITLE     Sodium channel subtypes are differentially localized to pre- and
            post-synaptic sites in rat hippocampus
  JOURNAL   J Comp Neurol 525 (16), 3563-3578 (2017)
   PUBMED   28758202
  REMARK    GeneRIF: The Nav1.2 are highly expressed in axon terminals in
            central hilus compared to stratum radiatum and in dendrites and
            spines in stratum radiatum compared to central hilus .
REFERENCE   4  (bases 1 to 8554)
  AUTHORS   Berret,E., Barron,T., Xu,J., Debner,E., Kim,E.J. and Kim,J.H.
  TITLE     Oligodendroglial excitability mediated by glutamatergic inputs and
            Nav1.2 activation
  JOURNAL   Nat Commun 8 (1), 557 (2017)
   PUBMED   28916793
  REMARK    GeneRIF: Knockdown of Nav1.2 channels in pre-oligodendrocyte alters
            their morphology, reduces axon-oligodendrocyte interactions and
            impairs myelination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8554)
  AUTHORS   Hovey,L., Fowler,C.A., Mahling,R., Lin,Z., Miller,M.S., Marx,D.C.,
            Yoder,J.B., Kim,E.H., Tefft,K.M., Waite,B.C., Feldkamp,M.D., Yu,L.
            and Shea,M.A.
  TITLE     Calcium triggers reversal of calmodulin on nested anti-parallel
            sites in the IQ motif of the neuronal voltage-dependent sodium
            channel NaV1.2
  JOURNAL   Biophys Chem 224, 1-19 (2017)
   PUBMED   28343066
  REMARK    GeneRIF: The polarity of (Ca(2+))2-CaMC relative to the IQ motif of
            NaV1.2 was opposite to that seen in apo CaMC-Nav1.2IQp (2KXW),
            revealing that CaMC recognizes nested, anti-parallel sites in
            Nav1.2IQp. (CaMC is C-domain residues of CaM, calmodulin).
REFERENCE   6  (bases 1 to 8554)
  AUTHORS   Sampo,B., Tricaud,N., Leveque,C., Seagar,M., Couraud,F. and
            Dargent,B.
  TITLE     Direct interaction between synaptotagmin and the intracellular loop
            I-II of neuronal voltage-sensitive sodium channels
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3666-3671 (2000)
   PUBMED   10737807
REFERENCE   7  (bases 1 to 8554)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   8  (bases 1 to 8554)
  AUTHORS   Kjaergaard,J.
  TITLE     [Hospitals--new charge by physicians on equally worthy leadership]
  JOURNAL   Sygeplejersken 92 (48), 38-39 (1992)
   PUBMED   1299025
REFERENCE   9  (bases 1 to 8554)
  AUTHORS   Noda,M. and Numa,S.
  TITLE     Structure and function of sodium channel
  JOURNAL   J Recept Res 7 (1-4), 467-497 (1987)
   PUBMED   2442385
REFERENCE   10 (bases 1 to 8554)
  AUTHORS   Noda,M., Ikeda,T., Kayano,T., Suzuki,H., Takeshima,H., Kurasaki,M.,
            Takahashi,H. and Numa,S.
  TITLE     Existence of distinct sodium channel messenger RNAs in rat brain
  JOURNAL   Nature 320 (6058), 188-192 (1986)
   PUBMED   3754035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 28, 2024 this sequence version replaced NM_012647.2.
            
            Summary: Voltage-gated sodium channels are transmembrane
            glycoprotein complexes composed of a large alpha subunit with four
            repeat domains, each of which is composed of six membrane-spanning
            segments, and one or more regulatory beta subunits. Voltage-gated
            sodium channels are responsible for the generation and propagation
            of action potentials in neurons and muscle. This gene encodes one
            member of the sodium channel alpha subunit gene family. In humans,
            variants of this gene are associated with seizure disorders and
            autism spectrum disorder. Mice homozygous for a knockout mutation
            die with severe hypoxia and extensive neuronal cell death, while
            gain of function mutations result in progressive seizure disorder.
            [provided by RefSeq, Nov 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X03639.1, M22254.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000003.1  70710956-70711111
            157-474             JAXUCZ010000003.1  70760908-70761225
            475-593             JAXUCZ010000003.1  70762057-70762175
            594-683             JAXUCZ010000003.1  70771422-70771511
            684-812             JAXUCZ010000003.1  70772388-70772516
            813-904             JAXUCZ010000003.1  70772894-70772985
            905-1177            JAXUCZ010000003.1  70774084-70774356
            1178-1241           JAXUCZ010000003.1  70777213-70777276
            1242-1383           JAXUCZ010000003.1  70778885-70779026
            1384-1590           JAXUCZ010000003.1  70779169-70779375
            1591-1878           JAXUCZ010000003.1  70780636-70780923
            1879-2226           JAXUCZ010000003.1  70794216-70794563
            2227-2356           JAXUCZ010000003.1  70799298-70799427
            2357-2595           JAXUCZ010000003.1  70803793-70804031
            2596-2769           JAXUCZ010000003.1  70805759-70805932
            2770-3126           JAXUCZ010000003.1  70807748-70808104
            3127-3606           JAXUCZ010000003.1  70812906-70813385
            3607-3727           JAXUCZ010000003.1  70821903-70822023
            3728-3882           JAXUCZ010000003.1  70823978-70824132
            3883-4056           JAXUCZ010000003.1  70825699-70825872
            4057-4179           JAXUCZ010000003.1  70828608-70828730
            4180-4461           JAXUCZ010000003.1  70831876-70832157
            4462-4515           JAXUCZ010000003.1  70832988-70833041
            4516-4653           JAXUCZ010000003.1  70835962-70836099
            4654-4758           JAXUCZ010000003.1  70836482-70836586
            4759-5029           JAXUCZ010000003.1  70840598-70840868
            5030-8554           JAXUCZ010000003.1  70841755-70845279
FEATURES             Location/Qualifiers
     source          1..8554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..8554
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="sodium voltage-gated channel alpha subunit 2"
                     /db_xref="GeneID:24766"
                     /db_xref="RGD:3632"
     exon            1..156
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            157..474
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    184..186
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="upstream in-frame stop codon"
     CDS             208..6225
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="sodium channel voltage-gated type II alpha
                     polypeptide; RIIA sodium channel protein; sodium channel
                     protein type II subunit alpha; sodium channel protein,
                     brain II subunit alpha; voltage-gated sodium channel
                     subunit alpha Nav1.2; sodium channel, voltage-gated, type
                     2, alpha 1 polypeptide; sodium channel, voltage-gated,
                     type II, alpha subunit; sodium channel, voltage-gated,
                     type 2, alpha 1 subunit; sodium channel, voltage-gated,
                     type II, alpha 1"
                     /codon_start=1
                     /product="sodium channel protein type 2 subunit alpha"
                     /protein_id="NP_036779.2"
                     /db_xref="GeneID:24766"
                     /db_xref="RGD:3632"
                     /translation="MARSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDE
                     DDENGPKPNSDLEAGKSLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAISR
                     FSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEY
                     TFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRT
                     FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN
                     KCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQND
                     ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL
                     TLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML
                     EQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKK
                     KQKEQAGEEEKEDAVRKSASEDSIRKKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSL
                     FSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRPSN
                     VSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIR
                     KRRSSSYHVSMDLLEDPSRQRAMSMASILTNTMEELEESRQKCPPCWYKFANMCLIWD
                     CCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVF
                     TGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLR
                     VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI
                     SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNL
                     VVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFV
                     RKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVD
                     ESDYMSFINNPSLTVTVPIALGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV
                     DIGAPAEGEQPEAEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI
                     VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
                     AYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
                     EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS
                     VVNNYSECQALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN
                     VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
                     KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVET
                     DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF
                     LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF
                     LVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS
                     GPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE
                     ESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAM
                     DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTL
                     KRKQEEVSAIVIQRAYRRYLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENS
                     TPEKTDVTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK"
     misc_feature    217..219
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    289..390
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    538..1575
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: I. /evidence=ECO:0000305"
     misc_feature    589..1512
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    589..1512
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    595..651
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    673..735
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    778..831
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    841..843
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    850..900
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    958..1017
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    1060..1062
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1078..1080
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1096..1098
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1114..1116
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1129..1131
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1195..1197
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    1225..1227
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    1291..1293
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    1411..1473
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    1609..1611
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1618..1620
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1657..1659
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1687..1794
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1783..1785
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1789..1791
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1798..1800
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1864..1866
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1867..1869
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1322892,
                     ECO:0000269|PubMed:20131913, ECO:0007744|PubMed:22673903;
                     Phosphoserine, by PKC, in vitro.
                     /evidence=ECO:0000269|PubMed:1322892,
                     ECO:0000269|PubMed:20131913, ECO:0007744|PubMed:22673903;
                     propagated from UniProtKB/Swiss-Prot (P04775.1);
                     phosphorylation site"
     misc_feature    1879..2334
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Cytoplasmic domain of voltage-gated Na+ ion
                     channel; Region: Na_trans_cytopl; pfam11933"
                     /db_xref="CDD:463401"
     misc_feature    1879..2334
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Cytoplasmic domain of voltage-gated Na+ ion
                     channel; Region: Na_trans_cytopl; pfam11933"
                     /db_xref="CDD:463401"
     misc_feature    1879..1881
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1924..1926
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine, by PKC, in vitro.
                     /evidence=ECO:0000269|PubMed:1322892; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1933..1935
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine, by PKC, in vitro.
                     /evidence=ECO:0000269|PubMed:1322892; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1972..1974
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    1978..2109
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2035..2037
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    2074..2076
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    2266..2268
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    2269..2271
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    2368..2370
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    2428..3246
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: II. /evidence=ECO:0000305"
     misc_feature    2479..3120
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    2479..3120
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    2485..2541
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    2575..2634
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    2677..2736
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    2743..2796
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    2845..2901
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    2932..2934
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds SCN2B, via carbonyl oxygen.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    2953..2955
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA, via amide nitrogen.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    2956..2961
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Binds SCN2B.
                     /evidence=ECO:0000250|UniProtKB:Q99250"
     misc_feature    2965..2967
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA, via carbonyl oxygen.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    3040..3042
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    3052..3054
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    3091..3153
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    3196..3816
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Sodium ion transport-associated; Region:
                     Na_trans_assoc; pfam06512"
                     /db_xref="CDD:461936"
     misc_feature    3196..3816
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Sodium ion transport-associated; Region:
                     Na_trans_assoc; pfam06512"
                     /db_xref="CDD:461936"
     misc_feature    3565..3705
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3775..4719
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: III. /evidence=ECO:0000305"
     misc_feature    3826..4653
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    3826..4653
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    3835..3888
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    3928..3984
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4027..4083
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4108..4164
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4216..4275
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4309..4311
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    4327..4329
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA, via amide nitrogen.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    4351..4353
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    4384..4386
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); glycosylation site"
     misc_feature    4492..4494
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    4534..4536
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Binds Mu-conotoxin KIIIA.
                     /evidence=ECO:0000250|UniProtKB:Q99250; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    4549..4614
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4627..4785
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Inactivation gate of the voltage-gated sodium
                     channel alpha subunits; Region: Na_channel_gate; cd13433"
                     /db_xref="CDD:240441"
     misc_feature    4627..4785
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Inactivation gate of the voltage-gated sodium
                     channel alpha subunits; Region: Na_channel_gate; cd13433"
                     /db_xref="CDD:240441"
     misc_feature    4669..4680
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="putative hydrophobic latch; other site"
                     /db_xref="CDD:240441"
     misc_feature    4669..4680
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="putative hydrophobic latch; other site"
                     /db_xref="CDD:240441"
     misc_feature    4672..4674
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Important for channel closure; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); other site"
     misc_feature    4723..4725
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:1322892,
                     ECO:0000269|PubMed:1658937; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    4744..5640
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: IV. /evidence=ECO:0000305"
     misc_feature    4798..5565
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    4798..5565
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:459842"
     misc_feature    4804..4857
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4891..4947
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    4984..5037
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    5077..5127
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    5185..5238
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    5464..5532
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     transmembrane region"
     misc_feature    5995..5997
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    6004..6222
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="propagated from UniProtKB/Swiss-Prot (P04775.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    6034..6036
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    6094..6096
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    6103..6105
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     misc_feature    6118..6120
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:20131913; propagated from
                     UniProtKB/Swiss-Prot (P04775.1); phosphorylation site"
     exon            475..593
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            594..683
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            684..812
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            813..904
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1177
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1241
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1383
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1590
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1878
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2226
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2356
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2595
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2769
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..3126
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3606
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3727
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3882
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4056
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4179
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4461
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4515
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4653
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4654..4758
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..5029
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..8554
                     /gene="Scn2a"
                     /gene_synonym="NachII; Nav1.2; RII/RIIA; RNSCPIIR; SCN;
                     Scn2a1; Scn2a2; ScpII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctgtcttt gcttttcctc tttagtaagg atattattgc acatgtgaga tttttacttc
       61 ctactgtagg ctgaattcta gaaacctgca ctggagactg ctacattcaa cacgcacatg
      121 gattctgtgc tatgattacc attcctttta tttcagcact ttcttacgcg aggagctaaa
      181 cagtgactaa agaagcagga tgaaaagatg gcacggtcag tgctggtacc tccaggacct
      241 gacagcttcc gcttctttac cagggaatcc cttgctgcta tcgaacagcg cattgcagaa
      301 gagaaagcta agagacccaa acaggaacgc aaggacgaag acgatgaaaa tggcccaaag
      361 ccaaatagtg acttggaagc aggaaaatcc cttcctttta tttatggaga cattcctcca
      421 gagatggtgt cagaaccact ggaggacctg gacccctact atatcaataa gaaaaccttt
      481 atagtattga ataaggggaa agcaatctcg cggttcagcg ccacctctgc cctgtacatt
      541 ttaactccct tcaaccccat tagaaaatta gctattaaga ttttggtaca ttctttattc
      601 aatgtgctta tcatgtgcac aattcttacc aactgtgtgt ttatgaccat gagtaaccct
      661 ccagactgga caaagaatgt ggagtatact tttacaggaa tttatacttt tgaatcactt
      721 attaaaatcc ttgcaagggg cttttgtcta gaagatttca catttctacg ggatccctgg
      781 aattggttgg atttcacagt cattactttt gcgtatgtaa cagaatttgt aaacctaggc
      841 aatgtttcag ctcttcgaac tttcagagtc ttgagagctt tgaaaactat ttctgtaatt
      901 ccaggcctga agaccatcgt gggggccctg atccagtcag tgaagaagct ctctgacgtc
      961 atgatcctca ccgtgttctg tctcagtgtc tttgctctaa tcgggctgca gctcttcatg
     1021 ggcaacctga ggaataaatg cttgcagtgg cccccagaca attctacctt tgaaataaat
     1081 atcacttcct tctttaataa ctcattggat tggaatggta ctgccttcaa taggacggtg
     1141 aacatgttta actgggacga atatattgaa gataaaagtc acttttattt tttggaagga
     1201 caaaacgatg ctctgctttg tgggaacagc tcggatgctg gacagtgtcc agaaggatac
     1261 atctgtgtga aggctgggag aaaccccaac tacggctaca caagttttga caccttcagc
     1321 tgggccttct tgtccttatt tcgtctcatg actcaagact tctgggaaaa cctttatcag
     1381 ctgaccttgc gtgctgccgg gaaaacatac atgatatttt ttgtgctggt cattttcttg
     1441 ggctcattct acctgataaa tttgatcctg gctgtggtgg ccatggccta cgaggaacag
     1501 aaccaggcca cactggagga ggctgaacag aaggaggcag agtttcagca gatgctggag
     1561 caactgaaga agcagcagga ggaagctcag gcagcagctg cagcagcgtc cgcagaatcc
     1621 agagacttca gcggggcagg cgggataggt gttttctcgg agagttcgtc agtagcctca
     1681 aagttaagtt ccaaaagtga aaaggagttg aaaaacagaa gaaagaaaaa gaaacagaaa
     1741 gaacaggctg gggaggaaga gaaggaagac gcggtgcgga aatctgcctc tgaggacagc
     1801 atacgaaaga aaggcttccg gttttccctg gaaggaagta gattgaccta cgagaagaga
     1861 ttttcctctc cgcaccagtc tctcttgagc atccgaggct ccctattttc tccaagacgc
     1921 aacagtagag caagcctttt cagcttcaaa ggtcgagtga aggatattgg ttccgaaaat
     1981 gactttgcag acgatgaaca cagcacattt gaggacaacg acagcagaag agactctcta
     2041 tttgtaccac acagacatgg agaaaggcgt cctagcaatg tcagccaggc cagccgtgcc
     2101 tcccggggga tacccactct acccatgaat gggaagatgc acagtgcagt ggactgcaac
     2161 ggtgtggtgt ccctggttgg aggcccctct gcgctcacat cgcctgtggg gcagctgctg
     2221 ccggagggca caactactga gacagaaata aggaagagga gatccagttc ttaccacgtc
     2281 tctatggact tgttggaaga cccttcaagg caaagggcaa tgagtatggc cagtattttg
     2341 acgaacacta tggaagaact tgaagaatcc agacagaaat gcccaccctg ctggtataaa
     2401 tttgctaata tgtgcctgat ttgggactgt tgtaagccat ggctaaaggt aaaacacgtt
     2461 gtcaatctgg tagtgatgga tccatttgtt gacctggcca tcaccatctg cattgtgtta
     2521 aatacgctct tcatggccat ggagcactac cccatgactg agcagttcag cagtgtgctg
     2581 tctgttggga atttggtctt cactgggatc ttcacggcag aaatgtttct caagataata
     2641 gccatggatc catattatta cttccaagaa ggctggaata tctttgatgg ctttatagtg
     2701 agccttagtt taatggaact cggcttggcg aatgtggaag gattgtcagt tctccgatca
     2761 ttccggctgc ttagagtctt caagttggca aagtcctggc ccacactgaa catgctcatt
     2821 aagatcatcg gcaactcggt gggtgcactg ggcaacctga ccctggtgct ggccatcatc
     2881 gtcttcattt ttgctgtggt cggcatgcag ctgtttggaa agagctacaa ggagtgtgtc
     2941 tgtaagattt ccaatgattg tgagctcccg cgctggcaca tgcacgactt cttccactcc
     3001 ttcctgatcg tgtttcgagt gctgtgtggg gagtggatag agaccatgtg ggactgcatg
     3061 gaggtcgcgg gccagaccat gtgccttact gtcttcatga tggtcatggt gattgggaac
     3121 cttgttgtcc tgaacctctt cttggccttg ctcctcagtt ctttcagctc agacaacctg
     3181 gctgccacag atgacgataa cgaaatgaac aacctccaga tagccgtggg aaggatgcag
     3241 aagggaattg attttgttaa aaggaagata cgtgaattca ttcagaaagc ctttgtcaga
     3301 aagcagaaag ctttagatga aatcaaaccg ctggaagatc tgaataacaa gaaagacagt
     3361 tgtatctcca accacacgac catagaaata ggcaaggacc tcaattacct caaagatgga
     3421 aacgggacga ccagtggcat aggcagcagt gtggagaagt atgtggtaga tgagagtgat
     3481 tacatgtcgt tcataaacaa ccccagcctc accgtgactg tgcccatcgc ccttggagag
     3541 tctgactttg aaaacttaaa cacggaagaa ttcagtagtg agtcagatat ggaagaaagc
     3601 aaggagaaat tgaatgcaac tagctcatct gagggcagta cggttgatat aggcgctccg
     3661 gcagagggag agcagccaga ggccgaaccg gaagaatcgc ttgaaccgga agcgtgtttc
     3721 acagaagact gtgtgagaaa gttcaagtgt tgtcagataa gcatagaaga gggcaaaggc
     3781 aagctctggt ggaacttgag gaaaacgtgc tacaagatag tagagcataa ctggtttgaa
     3841 accttcatcg tctttatgat tctgctcagc agtggtgctc tggcctttga agacatttat
     3901 attgagcagc gaaagaccat caagaccatg ctggagtatg ctgacaaggt tttcacttat
     3961 atcttcatcc tggagatgct tctaaagtgg gtggcctatg gtttccaaat gtatttcacc
     4021 aatgcctggt gctggctgga cttcctgatc gttgatgtct ccttggttag cttaactgca
     4081 aatgccttgg gctattcgga acttggtgcc atcaagtccc tccgaacgtt aagagctctg
     4141 agacctctac gagccttatc ccgatttgaa ggaatgaggg ttgttgtaaa cgctctctta
     4201 ggcgccatcc cctccataat gaacgtactt ctggtctgcc tgatcttttg gctaatattc
     4261 agtatcatgg gggtgaatct ctttgctggc aagttctacc attgcatcaa ctacaccacg
     4321 ggggaaatgt ttgatgtgag cgtggtcaac aactacagtg aatgccaagc tctcattgag
     4381 agcaatcaga cggccaggtg gaagaacgtg aaggtcaact tcgataacgt gggactcgga
     4441 tacctttctc tgctccaagt agccaccttt aaaggatgga tggatatcat gtatgcagct
     4501 gttgactcaa gaaatgtaga actgcagccc aaatacgaag acaatctcta catgtacctt
     4561 tactttgtca tcttcatcat cttcggctca ttcttcaccc tgaacctgtt cattggtgtc
     4621 atcatagaca acttcaacca gcagaagaag aagtttggag gtcaagacat ctttatgaca
     4681 gaagaacaga agaaatacta caatgcaatg aagaagctcg gctccaagaa accgcagaag
     4741 cccattcctc ggcctgcaaa caaatttcaa gggatggtct ttgattttgt aaccaaacaa
     4801 gtctttgaca tcagcatcat gatcctcatc tgcctcaaca tggtgaccat gatggtggaa
     4861 acggacgacc agagtcagga gatgaccaac atcctgtact ggatcaacct ggtgttcatt
     4921 gtcctgttca cgggcgagtg tgtgctgaag ctcatctccc tccgccatta ttatttcacc
     4981 atcggctgga atatttttga ttttgtggta gtcatcctct ccattgtagg aatgtttctc
     5041 gcggagctga tagagaagta tttcgtgtcc cctaccctgt tccgagtcat ccgcctggcc
     5101 aggattggac gaatcctacg cctgatcaaa ggcgccaagg ggatccgcac tctgctcttt
     5161 gctctgatga tgtcccttcc tgcgctgttc aacatcggcc tcctgctttt cctggtcatg
     5221 ttcatctacg ccatctttgg gatgtccaac tttgcctacg ttaagaggga agttggaatt
     5281 gatgacatgt tcaactttga gacttttggc aacagcatga tctgcctgtt ccaaatcacc
     5341 acctctgccg gctgggacgg actgctggcc cctatactaa atagcggacc tcctgactgt
     5401 gaccctgaaa aagatcaccc tggaagctcg gtgaaggggg actgtgggaa cccatctgtg
     5461 gggattttct tttttgtcag ctacatcatc atatccttcc tggtggtggt gaacatgtac
     5521 atcgctgtca tcctggagaa cttcagcgtc gccaccgaag aaagtgcaga gcctctgagt
     5581 gaggacgact ttgagatgtt ctacgaggtc tgggagaagt tcgaccctga cgccactcag
     5641 ttcatagagt tctgcaagct ttctgacttt gcagctgccc tggatcctcc cctcctcatc
     5701 gcaaagccaa acaaagtcca gctcattgcc atggacctgc ccatggtgag tggagaccgc
     5761 atccactgcc tggacatctt gtttgctttt acaaagcggg tcctgggcga gagtggagag
     5821 atggacgctc ttcgaatcca gatggaagaa aggttcatgg cttccaaccc ctccaaggtc
     5881 tcttatgagc ccattaccac caccctgaaa cggaaacaag aggaggtgtc tgctattgtc
     5941 atccagcgag catacaggcg gtatctcctg aagcagaaag ttaagaaagt ttcgtctatc
     6001 tataaaaaag acaaaggtaa agaagacgag ggaacgccca tcaaagaaga catcatcaca
     6061 gataaactga acgagaattc aactccagag aagactgatg tgacaccttc cacaacttct
     6121 ccaccttcct acgatagcgt gacgaaaccg gagaaggaaa aatttgaaaa ggacaaatca
     6181 gaaaaagagg acaaagggaa agatatcagg gaaagtaaaa agtaaaaaaa taaaataata
     6241 ataataataa cgaaaattaa aaattaaaaa aaaaagaata ttccatttcg tgatcaactg
     6301 tttacagcct gtgttggtga tgtatctgtg actccctcag gaggtccatg ccaaactgac
     6361 tgtttctcta agtgtatact taaggtcagt gcctataaca agacaggacc tcgggtcagc
     6421 acactgggat tcaccaaacc agacaaagag caccgacggg aggcttctat gttcacaacc
     6481 agctgacact gctgaagagc ggagagcaat ggctactcag actagaagaa catggaaacg
     6541 gggaggaaag ttaaattttt atgtaaattt aacatgtgac acttgatagc ggtaactgtc
     6601 accactgttt gtgttttaac tgccacacct gccatatttt tacaaaatgt gtgctgtgac
     6661 tttatcactt tttttttttt tgattcacgg gttgtttact cttatatgtg actatttttg
     6721 taaacgggtt tatgttcggg gagagggatt acggagggga ttcgacgttt ctctatgtat
     6781 aacgagatct attttcaacg aaggtaatgc tgcagctctc attcacacac gacgatatcc
     6841 catcacacca ggaaagagct tacttctcat ttcaggatgt ttttagattt tttgaggtgc
     6901 ttaaatagct attcatattt ttaaggtgtt tcatccagag gaattttaat gtgcctgtaa
     6961 atgttccata gaaccacaac catcaaaaag agttgtttta tttttacata gttcattata
     7021 tgtacatgta tatatgtcta tatgtatatg gccgtgtata tacatatata tgtatacaca
     7081 catgcataca tatgcacaca cagaccatca catgctcaga gtcctgacag catgactata
     7141 acattttttt aataagtgtc ctttggtaaa aaaaatatat atatacatat atatatatct
     7201 cctatcagtc ctttctaaga aacccaaact accaaaaacc acccccacgg ccactttctg
     7261 aagttggttc tgcttttttt tccctgcagt attgtttagc catcttctgc tcttggtaag
     7321 gttgacatag tgtatgtcaa ttaaaaaaca acaacagcaa caaagtctgc tttgtaaata
     7381 gtaattttac ccagtggtgc atgtttgagc aaatgaaaat gatttaagca cagtatttac
     7441 tgcatcaaat atgtaccaca gttaagtata gtttgcaagc tttcaacagg cgacatggtg
     7501 tcactgggtc ccttagagtt tgaagctgtc accgctgcat gtctctcttg ctgatgccgc
     7561 tgtatcttaa cccttctgct gttcagaagt ctaacaggga agccatacgt cggtggcgaa
     7621 gtgaagcaaa tcggtccacc aggaactcac tcttcgtgac atgagccatg ggttgcggta
     7681 aacgggaagg agatccttgt tcttggttct cccaaacctt aatggaacag ccggtgagat
     7741 gtctgacagt gtaagctgct tagatctgtt aaaagtatgt gcttcgagtt ttctaaggaa
     7801 atatacatat tgtaaaaaag gggggctcat tttattttat ttcaaagcct tttgtacata
     7861 aaatgggaaa ttaaaagtat cttcaggttg acgtcacagt tctaccgtta gtttctgttc
     7921 cccggcactt tttaatcaag gcacttcgtc acggaagaga taaggcctaa gaggcagtgt
     7981 agggctctgg ctgtcgttgt tggtactgtg gacttgcgcg tatttccact tgaaacaatt
     8041 ctcattccaa gtctaatgtc catttgcttt caatagtgat gccttatcat tgacaagaga
     8101 tttcaagggg agcagatgac actcttggca ttgcctgagt aggatgtcct cacctagtgt
     8161 ttctcctcta ctcatccatc ttttttaatg ttcgtttaca cagatagata gatggataga
     8221 tagaatctta ctcatccaca tggcaccaga gctgtttcag gtatgattcg ggaaccaagc
     8281 gctcgctctc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     8341 tctgttttcc acaaaaccag ttagtgaaat gatatcgcca attacagcca aacactttgt
     8401 ttcacagaca accttcaatg tagattcttt atactaaagc tgttgacttg tagcgtgttc
     8461 atgaatgcat gcaggaaaat gctattacca tacagagcta ccggtaagcc acattacgat
     8521 caagccaaaa gaataaagat tttttttttg cttt
//
LOCUS       NR_199266                641 bp    RNA     linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 11, non-coding RNA.
ACCESSION   NR_199266
VERSION     NR_199266.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 641)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 641)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.985397.1,
                                           SRR26360190.2416032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-641             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..641
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     misc_RNA        1..641
                     /gene="Mrps6"
                     /product="mitochondrial ribosomal protein S6, transcript
                     variant 11"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    106..226
                     /gene="Mrps6"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001437294.1"
                     /note="predicted ORF does not meet quality criteria for
                     protein coding locus with longer protein data"
     exon            151..641
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg gtatttcttg gtggattttt atgccccaac
      181 aaatgctgtg gaaagcatgc tggaacactt ggcacgagac actgatgtgg ttagaccaaa
      241 tattgtgaaa caccctctga cccaggaagt aaaagagtgt gacggcatag tcccagtccc
      301 tcttgaagaa aaactgtatt caacaaagag aaggaagaag tgagaagatt caccagatgt
      361 ggctatgttc aattctaagt gcaccatggg tgctgatagg tttgtctagg atgctttagc
      421 ccgtgaccat tttgctgcag atggggactg ctggccgaga cctgctctgt cacccctgct
      481 gatatttcac cctcactgtg tgattgtcag ggtgcggtgg ggctggtgtt cacagtccca
      541 ctgcagagtt tcgaagaaca aaatgtttgt cattcacact cggttgtctt gtaaacctgt
      601 gtggaacaca gagcagagta ataaacatgg ttttatcaac a
//
LOCUS       NM_001437710            1961 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus COP9 signalosome subunit 7B (Cops7b), transcript
            variant 1, mRNA.
ACCESSION   NM_001437710
VERSION     NM_001437710.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.36206.1,
                                           SRR26643288.38574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000009.1  94691468-94691555
            89-266              JAXUCZ010000009.1  94693686-94693863
            267-342             JAXUCZ010000009.1  94697608-94697683
            343-431             JAXUCZ010000009.1  94702271-94702359
            432-634             JAXUCZ010000009.1  94705054-94705256
            635-740             JAXUCZ010000009.1  94706847-94706952
            741-1961            JAXUCZ010000009.1  94710439-94711659
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1961
                     /gene="Cops7b"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
     exon            1..88
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            89..266
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..899
                     /gene="Cops7b"
                     /note="COP9 (constitutive photomorphogenic) homolog,
                     subunit 7b; COP9 constitutive photomorphogenic homolog
                     subunit 7B"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b"
                     /protein_id="NP_001424639.1"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFG
                     ELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSAAQQNKLKHLTIV
                     SLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGR
                     DIQKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKK
                     TLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH"
     misc_feature    366..635
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    366..635
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    600..749
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     misc_feature    600..749
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     exon            267..342
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            343..431
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            432..634
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            635..740
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1961
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtccga tcatggaagc ttgacaacct gcaggcaggc tctgggaggc cgagacatcg
       61 gcgaagagaa cagagtcggc ggggacagat ctcaagacca gagaatggca ggtgaacaga
      121 aaccctcaag taacctcttg gagcagttta ttttattagc caaaggcacc agcggctcag
      181 ccctcaccac tctcataagc caggtactgg aggctcctgg agtttatgtt tttggagaac
      241 tactggagtt ggccaatgtt caggagcttg cagaaggagc taatgctgca tatttgcagt
      301 tgctgaacct gtttgcctat ggtacatacc cggattacat agccaacaag gagagcctgc
      361 cagaactgag cgcagcccag cagaacaagc tgaagcatct taccatcgtg agtttggcat
      421 caagaatgaa gtgtatcccc tactctgtgc tgctgaagga cctggagatg aggaatctcc
      481 gggaactaga agaccttatc attgaggctg tctacactga catcatccag ggcaagctgg
      541 accagcgaaa ccagctcctg gaagtggatt tctgcattgg ccgtgacatc cagaagaaag
      601 atatcaataa tattgtcaag accttgcatg aatggtgtga cggctgtgag gcagttctcc
      661 tgggcattga gcagcaagtt ctgagagcca accagtacaa agagaaccac caccggactc
      721 agcagcaggt ggaagccgag gttagcaaca ttaagaagac actcaaagca acagcgtcct
      781 cctcagctca ggaaatggag cagcaactgg ctgaacggga gtgtcccccc catactgagc
      841 agaggcaacc cactaagaag atgtccaaag tgaaaggtct ggtctccagc cgccactagg
      901 gccggctggg gcagctggca ctcagcaggc ctgggtcagg tgggagggga cacccagggc
      961 ctatttcctc ccctctctaa ctgcagtgag ttccagatct gcccgcccct caccagtacc
     1021 tccccatcca ttggtaccat ttcggaaaat gattgctcct cccttgcctc ctttcctagt
     1081 tgttcccttc agactcaggg gctcaacgga tgccatccta acagggtcca acactgcctg
     1141 gcttccctgc agggtccttg tctctgtgat gggctacctc cctcccagtt gttcttttgc
     1201 ccctgtcatt ttgtcaggct ggtcctaagc tggaggcagt ttccccagcc ctgagggatg
     1261 actgtggagg tggctcctct ctgagtgaag agggggcctt gcttctccag cctcgtgtac
     1321 cacagtaccc acaatggtgc aagtgtctct agccaggtag ccacattgtt tccctctcct
     1381 gccttacccc tgttggcagt gccagtgcag gccatggagg gatgtggtgc tgggctatgt
     1441 ttactaaacc tttgggtttt cagcctctta agcccagcca ggatctctca tcgagttgag
     1501 gcactaggct gactaacctc tggtgtctga taccagtggg gggtgcttgg gtctgtgggc
     1561 ggcagaaggc gtttctccta gcttggtgtc ctctgctgac tgctcttcct gctgcctctg
     1621 actgctcagc cttgatttgg catttaggct gcccactgcc cactgggatt gtctggcaac
     1681 atttgctctc ccaagatctt tcatgcctcc tggctgcccc tggggtagga gtggtggtgc
     1741 cgaagcccct cagactggtg aaggaccatt gctgcttctt tctccttcct tcccacccct
     1801 ccttggctgg caacccagaa ccctctgata acatcatact ccactcctgg ccagagaaaa
     1861 ggacttgact agactttctg aacttgaaca gtttcaggtt atattttaat ttttttttgt
     1921 acaggttgat tctaatacat ttcaacatgc ttttttctcc c
//
LOCUS       NM_053449               8105 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus histone deacetylase 4 (Hdac4), transcript variant
            3, mRNA.
ACCESSION   NM_053449 XM_001067733 XM_343629
VERSION     NM_053449.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8105)
  AUTHORS   Gu,X., Li,F., Che,X., Wei,X. and Li,P.
  TITLE     HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model
  JOURNAL   BMC Musculoskelet Disord 25 (1), 467 (2024)
   PUBMED   38879481
  REMARK    GeneRIF: HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8105)
  AUTHORS   Zhang,D., Du,J., Yu,M. and Suo,L.
  TITLE     Urine-derived stem cells-extracellular vesicles ameliorate diabetic
            osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering
            microRNA-26a-5p
  JOURNAL   Cell Biol Toxicol 39 (5), 2243-2257 (2023)
   PUBMED   35554780
  REMARK    GeneRIF: Urine-derived stem cells-extracellular vesicles ameliorate
            diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by
            delivering microRNA-26a-5p.
REFERENCE   3  (bases 1 to 8105)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7. PMID: 36806965]
REFERENCE   4  (bases 1 to 8105)
  AUTHORS   Moreno-Ruperez,A., Priego,T., Gonzalez-Nicolas,M.A.,
            Lopez-Calderon,A., Lazaro,A. and Martin,A.I.
  TITLE     Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm
            and Gastrocnemius Proteolytic Activity in Septic Rats
  JOURNAL   Int J Mol Sci 23 (7), 3641 (2022)
   PUBMED   35408999
  REMARK    GeneRIF: Role of Glucocorticoid Signaling and HDAC4 Activation in
            Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8105)
  AUTHORS   Wei,W., Chen,W. and He,N.
  TITLE     HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation
  JOURNAL   J Transl Med 19 (1), 258 (2021)
   PUBMED   34118928
  REMARK    GeneRIF: HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8105)
  AUTHORS   Fischle,W., Dequiedt,F., Hendzel,M.J., Guenther,M.G., Lazar,M.A.,
            Voelter,W. and Verdin,E.
  TITLE     Enzymatic activity associated with class II HDACs is dependent on a
            multiprotein complex containing HDAC3 and SMRT/N-CoR
  JOURNAL   Mol Cell 9 (1), 45-57 (2002)
   PUBMED   11804585
REFERENCE   7  (bases 1 to 8105)
  AUTHORS   Lu,J., McKinsey,T.A., Zhang,C.L. and Olson,E.N.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   8  (bases 1 to 8105)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   9  (bases 1 to 8105)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 8105)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 9, 2025 this sequence version replaced NM_053449.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.23282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000009.1  100197560-100197601 c
            43-281              JAXUCZ010000009.1  100164705-100164943 c
            282-353             JAXUCZ010000009.1  100076183-100076254 c
            354-595             JAXUCZ010000009.1  100050680-100050921 c
            596-746             JAXUCZ010000009.1  100034333-100034483 c
            747-867             JAXUCZ010000009.1  100024695-100024815 c
            868-989             JAXUCZ010000009.1  100018481-100018602 c
            990-1121            JAXUCZ010000009.1  100013993-100014124 c
            1122-1234           JAXUCZ010000009.1  100010352-100010464 c
            1235-1351           JAXUCZ010000009.1  100007494-100007610 c
            1352-1550           JAXUCZ010000009.1  100007207-100007405 c
            1551-1774           JAXUCZ010000009.1  100004898-100005121 c
            1775-2029           JAXUCZ010000009.1  99998890-99999144   c
            2030-2216           JAXUCZ010000009.1  99996052-99996238   c
            2217-2350           JAXUCZ010000009.1  99994292-99994425   c
            2351-2456           JAXUCZ010000009.1  99991738-99991843   c
            2457-2503           JAXUCZ010000009.1  99988140-99988186   c
            2504-2611           JAXUCZ010000009.1  99984745-99984852   c
            2612-2667           JAXUCZ010000009.1  99982715-99982770   c
            2668-2755           JAXUCZ010000009.1  99981864-99981951   c
            2756-2875           JAXUCZ010000009.1  99979516-99979635   c
            2876-2973           JAXUCZ010000009.1  99978680-99978777   c
            2974-3092           JAXUCZ010000009.1  99971610-99971728   c
            3093-3226           JAXUCZ010000009.1  99970072-99970205   c
            3227-3311           JAXUCZ010000009.1  99956805-99956889   c
            3312-3453           JAXUCZ010000009.1  99955846-99955987   c
            3454-8105           JAXUCZ010000009.1  99950972-99955623   c
FEATURES             Location/Qualifiers
     source          1..8105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..8105
                     /gene="Hdac4"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
     exon            1..42
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            43..281
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..3493
                     /gene="Hdac4"
                     /EC_number="3.5.1.98"
                     /note="isoform 3 is encoded by transcript variant 3; HD4"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 3"
                     /protein_id="NP_445901.1"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     AAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ
                     HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG
                     KESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQS
                     GVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVA
                     TALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVT
                     REGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHL
                     TPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHTQSLVGADRVSP
                     SIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKMIS
                     KPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEE
                     EVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRP
                     LSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQS
                     IWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFV
                     RLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAE
                     ESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLH
                     RYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANE
                     FAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDLT
                     AICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEYWRCLQRLSPT
                     VGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
     misc_feature    <527..712
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    <527..712
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    order(533..535,545..547,578..583,590..592,611..613,
                     623..628)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(533..535,545..547,578..583,590..592,611..613,
                     623..628)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    608..1195
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Interaction with MEF2A. /evidence=ECO:0000250"
     misc_feature    653..760
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    869..934
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    884..886
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZM9; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    974..1240
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    992..994
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1301..1318
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: PxLPxI/L motif, mediates interaction with ANKRA2
                     and 14-3-3 proteins.
                     /evidence=ECO:0000250|UniProtKB:P56524"
     misc_feature    1304..1306
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1655..1657
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1781..1849
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1883..2005
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1946..1948
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2126..2197
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2147..2149
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2150..2152
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2198..3409
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    2198..3409
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    2216..3490
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Histone deacetylase. /evidence=ECO:0000250"
     misc_feature    order(2642..2647,2669..2674,2756..2758,2762..2764,
                     3038..3040,3158..3160)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    order(2642..2647,2669..2674,2756..2758,2762..2764,
                     3038..3040,3158..3160)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    3389..3490
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Nuclear export signal. /evidence=ECO:0000250"
     misc_feature    3413..3490
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            282..353
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            354..595
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..746
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..867
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            868..989
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1121
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1234
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1351
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1550
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1774
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2029
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2216
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2350
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2456
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2503
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2611
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2667
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2755
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2875
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2973
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3092
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3226
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3311
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3453
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..8105
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggctct gcgctcgagg gggagcagca tcatggttca acgttcatct ctgcaaggcc
       61 aggtgacaac ttctgctctt cttgtggatt acttggttta caagacgctg ccagtgggac
      121 ttcgagtttg cgcagctggg acccgggcct cctcagtttt gtacctgcat gttctcgtgg
      181 gaatttggag cgtgttggag ccactgttta cctggacatc ttgagccatt tcgaacttaa
      241 ggcactgacg ctgctagcaa tgagctccca aagccatcca gatggacttt ctggccgaga
      301 ccagcctgtg gagctgctga atcctgcccg cgtgaaccac atgcccagca cggtggacgt
      361 ggctacagcg ctgcctctgc aggtggcccc tgcagcagta cccatggacc tgcgcttgga
      421 ccaccagttc tcactgccct tggaacctgc actgcgggag cagcaactgc agcaggaact
      481 cctagcactg aagcagaagc agcagatcca gcggcagatc ctcattgcag agttccagcg
      541 tcagcatgag cagttgtccc gacagcatga ggcacagctg catgaacata tcaagcagca
      601 gcaggagatg ctggccatga agcaccagca ggagctgctg gagcaccagc ggaaactgga
      661 gcggcaccgg caagagcagg agctggagaa gcagcaccgt gagcagaagc tgcagcagct
      721 caagaacaag gagaagggca aagagagtgc tgtggcgagc acagaggtga agatgaagct
      781 gcaggagttt gttctcaaca agaagaaggc tctggcccac cggaacctga accactgcat
      841 gtccagcgac ccccgctact ggtatgggaa gacacagcac agctcccttg accagagctc
      901 tccaccccag agtggggtgt cagcctccta caaccaccct gtcttgggaa tgtacgacgc
      961 caaagatgac ttccctctta ggaaaacagc ttctgaacct aacctgaaat tacggtcaag
     1021 gcttaagcag aaagtagctg agagacggag cagccccctg ctgcgcagga aagatggccc
     1081 tgtggccact gctctaaaaa agcgacccct ggatgttaca gactccgcat gtagcagcgc
     1141 ccctggctcc ggtcccagct cccccaatag cagctctggc aacgtcagca ccgagaatgg
     1201 cattgcaccc accgtgccca gcactccagc tgagacgagc ttggcacaca gacttgtgac
     1261 tcgagaaggc tctgttgccc cacttcctct ctatacatca ccatccttgc ccaacatcac
     1321 cctgggactt cctgccactg gccctgctgc tggtgcagca ggccagcagg atgctgagag
     1381 gcttgctctc ccagccctcc agcagcgaat ctccttgttc cctgggaccc acctcacccc
     1441 atacctgagc acctcgcccc tggagcggga cggtggagca gctcacaacc ccctcctgca
     1501 gcacatggtc ctgctggagc agccacccac ccagacgccc cttgtcacag gcctgggggc
     1561 actgcccctc cacacacagt ccctggttgg tgcggacagg gtgtccccat ccattcacaa
     1621 gctgcggcag caccgacctc tggggcgcac gcagtcagca cccctgccgc agaacgcaca
     1681 ggccctgcag cacctggtga tccagcagca gcaccagcag tttctggaga agcacaagca
     1741 acagttccag cagcagcagc tgcacctcag caagatgatt tctaaaccca gtgagccacc
     1801 tcggcagcct gagagccacc cggaggagac agaggaggag ctccgtgaac accaggcctt
     1861 gctggatgag ccctacctag atcggctccc tgggcagaag gagccctcct tagctggtgt
     1921 gcaggtgaag caggagccca tcgagagtga ggaggaagaa gtagaggcca ctcgagaggc
     1981 ggaacccagc cagcgcccag ccactgaaca ggagcttctc tttagacagc aagctcttct
     2041 gctggagcag cagaggatcc accagttaag gaactaccag gcatctatgg aggctgctgg
     2101 catccctgtg tcatttggca gccacagacc tctgtctcgc gcacagtcct ccccagcatc
     2161 tgccaccttc cccatgtcag tccaggagcc ccccaccaaa ccaaggttca ccacaggcct
     2221 tgtgtatgac acactcatgt tgaagcacca gtgcacctgt gggaacacca acagccaccc
     2281 ggagcatgct gggaggatcc agagcatctg gtcccgcctg caggagactg gcctccgtgg
     2341 caagtgtgag tgcatccgcg gacgcaaggc cacactggaa gagctgcaga cagtgcactc
     2401 ggaggcccac acactcctct atggcacaaa ccctctcaac agacagaaac tggacagctc
     2461 gctgacctcc gtgtttgtca ggcttccttg tggtggtgtt ggggtggata gtgataccat
     2521 atggaatgag gtgcactcgt ctggggcagc ccgcctggct gtaggctgtg tagtggagct
     2581 ggtcttcaag gtggccacgg gagagctaaa gaatggcttt gctgtggttc gtcccccagg
     2641 acaccatgcc gaggagagta cacccatggg tttctgctac tttaattctg tggcaattgc
     2701 agccaaactt ctccagcaga ggttgaatgt gagcaagatc ctcattgtag actgggatgt
     2761 gcaccatggg aatgggaccc agcaggcctt ctacaatgac cccaatgttc tctacatgtc
     2821 cctgcaccgc tatgacgatg ggaacttctt cccaggaagt ggagcaccag atgaggtggg
     2881 cacagggcca ggcgtgggtt tcaatgtcaa catggccttc acgggtggcc tcgatccccc
     2941 catgggagac gccgagtacc tggcagcctt cagaacggtg gtcatgccaa tcgcaaatga
     3001 gtttgcccca gatgtggtac tggtgtcctc gggcttcgat gctgtggagg gccaccccac
     3061 acctcttgga gggtacaatc tctctgccaa atgtttcggg tacttgacaa aacagctgat
     3121 gggcttagct ggtggccgga tcgtgctggc cctggaggga ggccatgacc tgacagccat
     3181 ctgtgatgct tctgaagcat gtgtttctgc tctgctggga aatgagcttg agcctctgcc
     3241 agaaaaggtt ctacatcaga gacccaatgc caatgccgtc cactccatgg agaaagtgat
     3301 gggcatccac agtgagtact ggcgctgcct gcagcgtttg tcccccactg tggggcactc
     3361 tctgattgag gcgcagaagt gtgagaatga agaagctgag acagtcaccg ccatggcctc
     3421 gctgtctgta ggcgtcaaac ctgctgagaa gagatctgag gaggagccca tggaggagga
     3481 gccaccactg tagccgaagc tgctgttctc tcctttgtct gtctgtctta aggctcagcc
     3541 aagaaacttt cccgtgtcac tcctgcgtcc tgccttggtg ctctctctga gtgcgaaggg
     3601 acagcaggtg tgaagcagca acgggaggcc tttctgccgc cctggaccac aggtctggag
     3661 acgcacacga acaccaggtg tggcagatca gatggaacac aggacagtgc gcaacacgtg
     3721 ggcacacaga catgccgcag aagccaagca cacgctgctg gggtccccca ggaaagccac
     3781 gaaggaagaa gcttgtggca acttgggcag agttgctgaa ttgagttgac atgaggaaaa
     3841 tgaaaatcaa agatctaata atacagaaca aacttgatta aaactggtgc ttaacatttg
     3901 attcttaccc acaatcccac agtctccgtg taaaccactc aactcatctt gtagcttttt
     3961 taaaaaaaaa aaaaaacaag aaaacaaaac agttttctat ggctctggcc tgccttgtga
     4021 accttagtgg ggtgctgtgg gggttcacag cttagcgagg acggagttgg aagaaacgtc
     4081 aaagaataaa aaactagaca gaacagaaat gggagcctgg gagtcagctg gagcttctcg
     4141 aagccatcgg aagatgcgag tttgtgcctt tttttattgc tctgatggaa ttttttgtgg
     4201 ctgggttttc tgaagtctga ggaacaatgc cttaagaaaa aacaaaaaca aaaacaaaaa
     4261 aacaccagta agaattggtg tgacagtgtc ctgtggctgg ctgagtctag tgatgctggc
     4321 ctggcattac aagagtggca ccagccactg tccccgaggg ccgaaggaca gccagccagc
     4381 cttgcttggt ttgatcaccg tttaaggaag gtgaggtagt tccaaaaagc agcgaacgcc
     4441 gccgccgccg gcagttttga agtctaacac gtttttaaac ggatccaaag tgttctttcc
     4501 tcatccgtca catagcagtt gagcatctcc attcgattgt gaagcatgtc gtaggcacat
     4561 tgcagtgtta cgatcggaat gcttttcatt aaaagcaggt agcatgaagt attgcttaaa
     4621 ttttaggtat aaataaatat atatatatat gtataatata tattccactg tattccaagc
     4681 taagaaactt gattcttatg agatcttgat aaaatattta taatgcattt atagacaaag
     4741 tatatataaa tatatataat aaatccagac cgcagaggtc ctggcaggcg aaagacgtgt
     4801 gtgttagctc tgaggtgctg agggctgggt ctggattgaa gcccatggat ttctgagctc
     4861 cagattggcc agcttccaga ttgccagcat gttcacccct gggcaatttc cctaccagtt
     4921 tgtactttaa ttttaattat tttctaacaa aacctctgcc ctttccaagc ctccatgcac
     4981 atatgtacct gatgagtttt tatagcaaaa gatataaact tgctgttgat ttttgtatga
     5041 atttttcaca aaaagatcct gaagaaaaca ttattttgtg gattttacat ttttcccctt
     5101 accattcagc agttttctga aggtggtaat gtctgaaact ttttctttct aaattcttac
     5161 ttgtacattt tttttagctc tgaaggttat ttttatggtt tgattttgtt tctttttgta
     5221 cagcaagcag ggctctgctt tgaccaggac cgctgctgtc atgcttggtt ttttagagca
     5281 aacctctcga gattgggcag caggtctgcg tggcaccctt gtcttgtaaa gctcaccggg
     5341 agctgcacag ccacgggctc ctgccccgca acactcatag tattacaagg gcgggcaggc
     5401 cgcatgagac acgagggcag tcagcatcaa tgagcgtgga cttgtaacca ctccatcagg
     5461 atagaactcc agctctagtt tcccaaagac cttcgaggcg agtccacaag cgcctgccca
     5521 gagcctggcc ctgcagctgt cagcaatttc cattgcggcc tcataacctg gactctggct
     5581 agagccacag ccctgggttt gtagcctgtg gctgctgaac caaggccttt gtccttgtcc
     5641 tgcaggaaca catagggtcc tgagggacag tcagtctttg tctttgctct tttttttttc
     5701 tatgacaact gactttttaa ctgctaactt cttttctagc acttaaagcc accaatttca
     5761 ttccaaagtg gagttcagac tggcgagagg aagttgagat actcagaagg gacatcaagc
     5821 taagtttctg aatttggtgg catttacagg gtagatggga actgggtcaa gcttttaacc
     5881 aacaggctga acacacattc ttggactttt gatcgctgtg ctgctatgag tgctaagcta
     5941 agacagtggg tagagaggtc ttaggacatg cctgactgtc ctccctgtgt cccttctggc
     6001 ccttggcgga agggacaaac ttgagggagc catgcagcct ctcccttgct tgtcactgca
     6061 tggtgacaga ggccagctag ctgctcttct ggcctccttg gtccattttc tgcataccct
     6121 gccacctgcc ctcttgtgcc agccacgact cgtgggagca tcatcttacc ttttcaggtg
     6181 atgggtagca ggccactcag tggccagggt actgtgagag gaactcactt tggttctatt
     6241 cagtcaccct ttgatgcagg ggcctggcca gggagccagc tcactccagc ttccctggga
     6301 gctgaaagca ttacctacca tatagccttt tctccccttt gaagacaggt gtggtccttc
     6361 ctcacagtca tcacccaggg cagagggcag aaggtcggcc ttgacctcca gggcaggacc
     6421 acagcactcc cctgcctgga ccttgaacct tccaccttct cccttccttt gcaaaggcct
     6481 tggtgggtgc tggcaaggga gccggagcaa gcactttaca cccctttaag gggagcccga
     6541 aggcaccgtg tcctcagggt gctggtgttc gctcaccctt ggggcttcca cctgcaccct
     6601 gagagcccac gccccaccag caggcggctg ttcccaaggc caccacctgc tgggacatcc
     6661 cagggctctg gcttgagggc tgctttatga aagtgtttca gtttttcttt attttcaaat
     6721 ctgtccccaa gaggaaggac caccctgtgg tggtctccgc agcactggtg atgggctcag
     6781 tcatgtttct ttcctcagaa cattccttcc ttcttcactg gtcccagcca cgtgctcatt
     6841 ccatccttct ttttgtagac tttgggccca tgtattttat gggcattgat acatatataa
     6901 atatatagat ataaatatat aaatatattt ttttaagttt cctacacctg gaggttgcat
     6961 ggacgtacgc cggcatgtct ttatattgta tacagatttt gcacgccaaa ctcggcagct
     7021 ttggggaagg agaagcattg cctttctctc ccctctcatg atgtttgcag atgcagaaat
     7081 ttttttctgt aaaacaaaac aaaaccttga aggagaagag gggggcgttt gagtcttact
     7141 gaacttattc ttaagaaatt gtacttttta ttgtaagaaa aataaaagga ctacttccac
     7201 actcgtcatt aagaaaagtt tacctagcac ctttgacata ccgatagaga gtcgattgta
     7261 tccacacgca agctccacat tcagaccctg ctgcctgtct gtcaagctgg ctgggggtgt
     7321 tttcttttgt tttgttggtt ttctcctctc tctccccgca cagggccagg tgcaccctgc
     7381 ctgctgtcac tggcctctgg tcgagaacct gaggttctgg tgagtcctgt ctcagcacaa
     7441 ctgtgtcgat gggttcattc cttctagaag acacggggct ggggttctgc actgggcaat
     7501 ccaggccttt gtgagcccta ggtctaaatg acacttggca ctggaggaaa ctatttctcc
     7561 ctctcaagga tccaggtgtg ctctgcaccc ggccttgatg gcctcaccgg ccttgagttg
     7621 atcaaagtct actatggaaa gagaagaatg cagacaggcc ttgttcgggg gtgtgcactc
     7681 cagtgaggag gtaccgtttc ccgatctgta agaatgttaa acatgctgtt ttcatgtatg
     7741 cacaggaggc tgacctctgt cagcaagagc tcactacaga agtgtggtcc aagccaccgg
     7801 agcgctgcca catgatgccg tgtgtgctcc acagccttga ccgccttcac tctgtaacag
     7861 cctgttttct ctttgattgt ctggacctcc cctccttggc gctttctcct cctggcgggg
     7921 ttgggggtca tgtttggttt tctcattctt gtttcgtttt tttttttgtg tgtgtggtgg
     7981 gtttcactga ccggcggtgc cctctggcgg tcacctcttt ccacctcccg ggtccagtgt
     8041 ttgtaccaca tcacacactt gtcgctctcg tggtgtaaat aaagactgcg ttaattgccc
     8101 tccca
//
LOCUS       NM_001437796             895 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family A, member 3 (Bpifa3),
            transcript variant 4, mRNA.
ACCESSION   NM_001437796 XM_039105884
VERSION     NM_001437796.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 895)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039105884.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3161349.1,
                                           SRR26360181.2037812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000003.1  163069924-163070103
            181-331             JAXUCZ010000003.1  163073784-163073934
            332-439             JAXUCZ010000003.1  163075743-163075850
            440-589             JAXUCZ010000003.1  163077544-163077693
            590-674             JAXUCZ010000003.1  163078635-163078719
            675-895             JAXUCZ010000003.1  163079636-163079856
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..895
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI fold containing family A, member 3"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
     exon            1..180
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="upstream in-frame stop codon"
     exon            181..331
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..884
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="BPI fold-containing family A member 3 isoform 4"
                     /protein_id="NP_001424725.1"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
                     /translation="MRLLDRLNVSGTVAPGMVSWLISGMNFQQQQEISINITNVQLDC
                     GGIQMAFPKEWFSANITLEFDIEFKLPFNSNILKTHAQMGLAAESWLEKDEFGRRKLV
                     TGRCQMEPSSDSASMTTEAASPKMKNFLHNLRESLGKVIPNLVESQNRWLLITLVSPE
                     SVKSLLSGSRGLPLPAIGQKEVLLVEILRLSQCVASAVPWKNDPQVPRHPVLSNNKL"
     misc_feature    231..674
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     misc_feature    231..674
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     exon            332..439
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            440..589
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..674
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..895
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccaat gtgagctagc cctgggagca gctgccagag ccatttgtac cacctcccac
       61 agcatgctgg gggcagccgt gcagccacct gccggaagac agctgtaagc ccatcgatct
      121 gggtggccat actcacagcc aactgcctgg gccctgctgg accattactg acacctgcag
      181 ttattgcaca gggcctcctg aagcacaatg cagaaggacg aatccagagc atgcgtcttc
      241 tggaccgtct gaacgtctca gggacagtgg ccccagggat ggtgagctgg cttattagtg
      301 gcatgaactt ccagcagcag caagaaatca gtatcaacat taccaatgtg cagctggact
      361 gtggcgggat ccagatggct ttccccaaag agtggttctc cgcaaacatc acacttgaat
      421 ttgacattga attcaaactg cccttcaatt cgaatatcct caaaacccat gcccagatgg
      481 gcctcgctgc agagtcctgg ctggagaaag atgagttcgg acggaggaag ctggtgacag
      541 gcaggtgcca aatggagccc agcagtgaca gtgcatccat gaccactgag gcagcctcac
      601 ccaagatgaa gaattttctc cacaacctca gagaaagcct ggggaaagtt atcccgaatt
      661 tggtagaaag tcaaaacagg tggctgctca taaccttggt cagccctgaa tcagtcaaat
      721 ctctgctatc aggctcgagg ggcctcccat tgcctgccat tggtcaaaag gaggtacttc
      781 tggttgagat cttacgtctc tctcagtgtg tggcttctgc tgtcccctgg aaaaatgacc
      841 cccaggtccc aagacatcct gtcctttcca acaataaact ctaactctga aggat
//
LOCUS       NM_001191557             798 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus synaptonemal complex central element protein 2
            (Syce2), transcript variant 1, mRNA.
ACCESSION   NM_001191557 XM_002728580
VERSION     NM_001191557.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 798)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   2  (bases 1 to 798)
  AUTHORS   Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E.
  TITLE     AGO4 regulates entry into meiosis and influences silencing of sex
            chromosomes in the male mouse germline
  JOURNAL   Dev Cell 23 (2), 251-264 (2012)
   PUBMED   22863743
REFERENCE   3  (bases 1 to 798)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   4  (bases 1 to 798)
  AUTHORS   Costa,Y., Speed,R., Ollinger,R., Alsheimer,M., Semple,C.A.,
            Gautier,P., Maratou,K., Novak,I., Hoog,C., Benavente,R. and
            Cooke,H.J.
  TITLE     Two novel proteins recruited by synaptonemal complex protein 1
            (SYCP1) are at the centre of meiosis
  JOURNAL   J Cell Sci 118 (Pt 12), 2755-2762 (2005)
   PUBMED   15944401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 9, 2025 this sequence version replaced NM_001191557.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000019.1  40191849-40191905   c
            58-188              JAXUCZ010000019.1  40191237-40191367   c
            189-342             JAXUCZ010000019.1  40176892-40177045   c
            343-531             JAXUCZ010000019.1  40175006-40175194   c
            532-798             JAXUCZ010000019.1  40173713-40173979   c
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..798
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /note="synaptonemal complex central element protein 2"
                     /db_xref="GeneID:364976"
                     /db_xref="RGD:1311867"
     exon            1..57
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..576
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 2
                     isoform 1"
                     /protein_id="NP_001178486.1"
                     /db_xref="GeneID:364976"
                     /db_xref="RGD:1311867"
                     /translation="MERQGSWLCSQVAVPPVELKDQEPPAIVESGEHQQNENHEETPS
                     SVAPSASCQLPGPFSSLDSSIETLKKKAQELIENINESRQKDHALMTNFRDSLKMKVS
                     DLTEKLEERMYQVYSHHSKIIQERLQEFTQKMAKISHLEMELKQVCQTVETMYKDLCV
                     QSEVPTSEEQNYKDGEC"
     exon            58..188
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            189..342
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            343..531
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            532..798
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgcgca gagggcggga acgcggaggc gggaaagacg gaatggagcg ccaaggaagc
       61 tggctgtgct cgcaggtggc cgtgcctccc gtggagttaa aggaccagga accgccagcg
      121 attgtggaga gcggagagca tcagcagaat gagaaccacg aggagacacc tagctcagtg
      181 gcgccgagtg ccagctgcca actaccagga cccttctcct ctctggactc tagcattgaa
      241 accctgaaga agaaagccca ggaactgatt gaaaacatca atgaaagcag gcagaaagac
      301 catgcactta tgaccaactt cagggacagc ctcaagatga aggtctcaga tctgacagaa
      361 aagttggagg aaaggatgta ccaggtatac agccaccaca gcaaaatcat tcaggaaaga
      421 ctacaagaat ttacccagaa gatggcaaag atcagtcatc tggaaatgga gctcaaacaa
      481 gtttgccaaa ctgtggaaac tatgtacaag gacctatgtg tccagtctga ggttcccact
      541 tccgaagaac agaattacaa ggatggtgaa tgctgactcc tgctaagagg cttccatctt
      601 aatgccttgt caccaagaga aggcacagag gctgtttaag ccatgctgat atgtcttaca
      661 gttctgtaac ccaacacaaa gccaccaatt atgtgtgtgc taattaccaa agtgtgataa
      721 ggttagaccc tgccataggc ctagccttag caaattctcc caacccacgt ctatagttga
      781 ttaaatgttt tgatttca
//
LOCUS       NM_001437763            2305 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 2, mRNA.
ACCESSION   NM_001437763 XM_006248396
VERSION     NM_001437763.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2305)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2305)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2305)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2305)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2305)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2305)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248396.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1099090.1,
                                           SRR26360172.1133587.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000011.1  77465394-77465485   c
            93-162              JAXUCZ010000011.1  77464858-77464927   c
            163-279             JAXUCZ010000011.1  77462369-77462485   c
            280-442             JAXUCZ010000011.1  77461993-77462155   c
            443-572             JAXUCZ010000011.1  77456828-77456957   c
            573-666             JAXUCZ010000011.1  77452674-77452767   c
            667-766             JAXUCZ010000011.1  77449073-77449172   c
            767-945             JAXUCZ010000011.1  77444544-77444722   c
            946-1055            JAXUCZ010000011.1  77442290-77442399   c
            1056-1165           JAXUCZ010000011.1  77440692-77440801   c
            1166-1308           JAXUCZ010000011.1  77435682-77435824   c
            1309-1457           JAXUCZ010000011.1  77433449-77433597   c
            1458-1589           JAXUCZ010000011.1  77424393-77424524   c
            1590-1746           JAXUCZ010000011.1  77412154-77412310   c
            1747-2305           JAXUCZ010000011.1  77410986-77411544   c
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2305
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..92
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            93..162
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            163..279
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     CDS             180..1976
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 1 is encoded by transcript variant 2; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 1"
                     /protein_id="NP_001424692.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWK
                     KLGEEPGDEMDVPKDELSIDLGTLFIGGTKPP"
     misc_feature    894..>1469
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    894..>1469
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    894..953
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    894..953
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    996..1025
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    996..1025
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    1047..>1127
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1047..>1127
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1059..1121
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1059..1121
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1146..1286
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1146..1286
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1353..1409
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1353..1409
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            280..442
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            443..572
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            573..666
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            667..766
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..945
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1055
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1165
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1308
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1457
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1589
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1746
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..2305
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag gtacgctgtg cgggtcgggc
       61 cctgaggtgg acgaacgcgg ggaaaagatg agtgattcct ggaagcagtg aagggcacgg
      121 ccttgggatt cttgattcct caaaggtcag cctagcaaca ggcataggtg gtagaaaaaa
      181 tgaagccagc gggtacagac ccaaggatct tgtctttagc tgctgaagta gcgaaaagtc
      241 ctgaacaaaa tgtccctgtt atattattga agttaaaaga aataataaac aacacccctt
      301 tgggaagctc agagttaaag aaagtcaagc aagatatata ttgttatgac ctcattcaat
      361 actgtctatt ggtcctcagt caagattctt ctcgaatcca gggtggttgg tctacaattt
      421 cccagctgac acagatacta agccattgct gtgtgggatt agagccagga gaagatggag
      481 aagaatttta caaggaatta cttccatcag ctgccgaaaa ttttcttgtc ctgggaagac
      541 gattgcaaac atgttttatc aatgcaacta agggtgaaga gcaagataaa ttactacatt
      601 ttttccaaat tgtgactgat tctctcttct ggctattggg aggtcatatt caactcatac
      661 agaatgtact gcagagtgat catttcttgc acctactgca aactgacaat gttcaaatag
      721 gagctacagt catgactctg cttcagaata tactacagat caacagtggt aatttactca
      781 aaatagaagg aaaagccctg cattctattt tagatgaaat tcttttcaag cttttgtcaa
      841 ctcctagtcc agtcataaga agtactgcta caaagctcct actggtattg gctgaatccc
      901 atcaggaaat tttgatttta ctgagactaa gtgcctgcta taaaggactt agaagtctgc
      961 taaataaaca ggaaactctt acagaattta gtcgagaact tagacagctc gttgatcttt
     1021 taacccctaa gatccaacag gaagtagaag aacagaaact acataaagca gcttgcttga
     1081 ttcaagccta ttggaaaggt ttccagacca gaaaaagatt aaagaagctt ccgtctgctg
     1141 tgattgcctt gcagaggagt ttcagagcta aacgaacaaa gatgttgttg gagctaaata
     1201 ggcagaagga agaagaagac ctcagattaa gattgcaact tcaaaaacag agagccatga
     1261 ggctttcccg agagtcacgc ttgagtatgc ttgaaataat tcatccaggt caagtggaga
     1321 aatacaatag ggaaatagaa gagaaatctg cattgactat ccagaaacat tggagagggt
     1381 acagggaaag gaagaatttt cgccaacaga ggccatctct cacagagtat aaagcagctg
     1441 tcacacttca gagagcagtt cttaaattcc tagcaaagtg ccgtaagaaa aagaaactct
     1501 ttgcctcttg gcatggactc caagaactca ctgatgcacg ccgagttgaa ctgaagcaac
     1561 aagtggatga ctatgtcaaa agacatccgg gctctcagat gtcagatgtg gccagcagag
     1621 agctccacgc acaagcacaa gaacgacttc aacactattt tatgggaaga gccatagaag
     1681 agcgagccca gcaacacagg gaagcattga tggctcagat cagcaccaat attgagcagt
     1741 tgatgaaggc accaagtctg aaggaggcgg aaggaaagga gcctgagcag ttcctgagta
     1801 gatctaggcc tgtggcagcc aaagccaagc aggcccacct taccaccctg aagcacatac
     1861 aggccccctg gtggaagaag ctcggagagg aaccagggga tgagatggat gttccaaagg
     1921 acgagcttag tatagattta gggactttat ttattggtgg aaccaagcct ccctagagag
     1981 ttactgggaa agccggcatt cttacctttt aagagattgt tggttttgcc tctggcatgc
     2041 aggaagacta ggtctatgcc agtggctttc cagagcatct tcttcatgaa cacttggaag
     2101 caaagagcag agcattgcct acctcactct cagttctttc cccatctcta caccctgtct
     2161 gtagtcacaa acagatttgt gggcttttaa ttgtgggaca gaactcaatg tgaaatttta
     2221 ttgttaattt gaaatttctt tcattctgtt ttctgactaa aagttgtttt gtttttgttt
     2281 ttaaataaat attgtttctg aaaaa
//
LOCUS       NM_001437690            4975 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 10,
            mRNA.
ACCESSION   NM_001437690 XM_039087896
VERSION     NM_001437690.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4975)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4975)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4975)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4975)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4975)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4975)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4975)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4975)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4975)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4975)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087896.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.46637.1,
                                           SRR26360176.2234693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-423             JAXUCZ010000011.1  98104416-98104454
            424-470             JAXUCZ010000011.1  98105694-98105740
            471-542             JAXUCZ010000011.1  98106090-98106161
            543-629             JAXUCZ010000011.1  98108322-98108408
            630-792             JAXUCZ010000011.1  98109928-98110090
            793-913             JAXUCZ010000011.1  98113029-98113149
            914-1045            JAXUCZ010000011.1  98115531-98115662
            1046-1252           JAXUCZ010000011.1  98117537-98117743
            1253-1373           JAXUCZ010000011.1  98123938-98124058
            1374-1529           JAXUCZ010000011.1  98124251-98124406
            1530-1619           JAXUCZ010000011.1  98124558-98124647
            1620-1712           JAXUCZ010000011.1  98126328-98126420
            1713-1769           JAXUCZ010000011.1  98128415-98128471
            1770-1802           JAXUCZ010000011.1  98129443-98129475
            1803-1997           JAXUCZ010000011.1  98131039-98131233
            1998-2107           JAXUCZ010000011.1  98131384-98131493
            2108-2267           JAXUCZ010000011.1  98133415-98133574
            2268-4975           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4975
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2324
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 10 is encoded by transcript variant 10;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 10"
                     /protein_id="NP_001424619.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEE
                     WGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDL
                     PGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDP
                     DGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIR
                     DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNS
                     YGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLE
                     SVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHE
                     EMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYIN
                     TKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKLIQDNRRETKNVASAGGGIGD
                     GGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVP
                     VARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQ
                     LYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2031..2303
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2031..2303
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..423
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..470
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..542
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..629
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..792
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..913
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1045
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1252
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1373
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1529
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1619
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1712
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1769
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1802
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1997
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2107
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2267
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..4975
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatgaccctg ctacatggaa aaactcaaga cacctttcta
      421 aaggagttga agcagaagaa tggggtaaat ttcttcacac caaaaacaag ctttacacag
      481 attttgatga aattcgacaa gaaattgaaa atgaaactga aagaatttca ggaaataata
      541 agggagtaag ccctgagcca atccatctca aggttttctc gcccaacgtt gtcaacctga
      601 cgcttgtgga tttaccagga atgaccaaag tacctgtagg tgatcagccc aaggatattg
      661 agcttcaaat cagagaactt attcttcggt tcatcagtaa tcccaattcc attatccttg
      721 ctgtcactgc tgcaaataca gatatggcaa cgtcagaggc acttaagatt tccagagagg
      781 tagatccaga tgggcgcaga actctagctg taatcaccaa gcttgatctc atggatgcgg
      841 gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaagctt ggaataattg
      901 gagtagttaa caggagccaa ctggacatta acaataagaa gagtgtaact gattcaatcc
      961 gtgatgagta tgcttttctt caaaagaagt acccatctct ggccaacaga aatggaacaa
     1021 agtatcttgc taggactctg aataggttac ttatgcatca tatcagagac tgtttaccag
     1081 agctgaaaac aagaataaat gtcttagctg ctcagtatca gtctcttcta aatagctatg
     1141 gtgagcccgt ggatgataaa agtgctactt tactccagct cattaccaag tttgccacag
     1201 agtattgtaa cactattgaa ggaacggcaa agtacattga aacttctgag ctatgtggtg
     1261 gtgctaggat ttgttatatt ttccatgaga cttttgggcg aaccttagaa tctgttgatc
     1321 cactaggtgg ccttaacact attgacatct tgaccgccat tagaaatgct actggccccc
     1381 gtccagcttt atttgtgcct gaagtttcat ttgagttact ggtcaaacgt cagattaagc
     1441 gtctagagga gcccagcctc cgctgtgtgg agctggtcca cgaggaaatg cagaggatca
     1501 ttcagcactg tagcaactac agcacacagg aactgttacg gttccctaaa ctccatgatg
     1561 ccatagttga agtagtgact tgtcttcttc gtaaaaggtt gcccgtgaca aatgaaatgg
     1621 tacataactt agtggcaatt gagctagcat atatcaacac aaaacacccc gactttgctg
     1681 atgcctgtgg gctaatgaac aataacatag aggaacaaag aagaaacaga ctagcaagag
     1741 aactaccttc cgctgtatcg cgagacaagt taattcagga caacagaaga gaaactaaaa
     1801 atgttgcatc tgcaggtggt ggaattggag atggtggtcg aattggagat ggtggtcagg
     1861 aaccgacaac aggcaactgg agaggaatgc tgaaaacttc aaaagctgaa gaattacttg
     1921 ctgaagaaaa atcaaaacca attccaatta tgccagcaag tccacaaaaa ggccatgctg
     1981 tcaatttgct agatgtgcca gttccagttg cacgaaaact gtctgcccga gaacagcgag
     2041 attgtgaggt tattgaaaga ctcatcaaat catattttct aattgtcaga aagaatattc
     2101 aagacagcgt cccaaaggca gtaatgcatt ttttggttaa tcatgtgaaa gatactcttc
     2161 agagtgaatt agtagggcag ctgtataagt catccttatt agatgacctt ctgactgaat
     2221 ccgaggacat ggcacagcga agaaaagaag cggctgacat gctgaaggca ttacaaggag
     2281 ccagtcaaat tattgctgaa atccgagaga ctcatctttg gtgaacagaa ctgtttggtc
     2341 ttctacactt tgctgacttg aacctactag ctactgccta cctgagtaga aatttattta
     2401 tggacttttg tgtatcgcag tgtatgaatt tgcttgtgtg aagactggct ataagctgaa
     2461 aagtatatta ttcattacaa gacaaatcac atgtttaatt cacatttttc aagtttccta
     2521 tgatgtatat caagtctgtc cgtttcagtc aaacttacaa gaacaattga tgttctagtt
     2581 gtacaaagca gtttgcctgt gcatatgatg acctgcgtaa ccttttttta gtcttaaagc
     2641 tgcagccgta gtcctcaaag aggaagctcc aggacatttc atgactataa tgcatgcact
     2701 atttatatag actgacctgg cttcaaaagg tggagcctgg cgagttcctc acataatcaa
     2761 tgtatccacc tatccttcat ttttatagtc ttaaaaaaca aacaaaattc tgaaacttct
     2821 gcagttttag gaaaaatata agatctgaaa gactcataaa gatgtaggaa cagactgtgt
     2881 aattaatggc tcctgagtct atactgccct aatgttagaa agtaaaatat gctttgattc
     2941 aaaataagcc tgaaaatata aattgacttc ctgcattaaa aataactatt aggaactttc
     3001 ttagtaacaa taactggtcc tgttagtttc taaatgactc agtgacaacc taaatttccc
     3061 taatttacaa gtacatcgat tgcagtccag atgcacctta gggtggggcg ctgactctgg
     3121 gctccgagac tcagttatgt gagacctaaa agtctactct gtatccactg gtaatgctac
     3181 tttatagttc cacaccaaca gaatacattt gtcaaagaaa aatacctgga catacacata
     3241 cacctaaaag cttatggact actaaactgt attcaggggt tgaggattta caacctattt
     3301 tgtgaaaact gcctgtgcaa ttcaatttct gacctagctg ggcagtggtg gtgcacacct
     3361 ttaatcccag cttttgggag gcagaggcag gtggatctct gagttcaagg ccagcctggt
     3421 ctacagagtt gagttccaag acaaccagaa ctacacagag aaaccctgtc ttgaaccccc
     3481 ctccccccaa aaaattgaaa cctaaataga aatctttgat gtatctagtt ttctctgacc
     3541 aaatgataca tttgtgttat aaatactaaa attcttttca ggtcaggcat cttatgaaat
     3601 actattagca aggaaaacaa gaacatgtta tctttagttt agatgcccat tgaaccatct
     3661 caaaaacaaa ggcagtctga taacagtacc agcttgacag tgagtataca ctgcctaaat
     3721 gtgttagcat acttaagaaa aatatcctgt tatctaacta ttaggtatcc atggtttatt
     3781 ttttaagaga gatgaccacc actgtagcct tttgaatttg taaagagaaa gaatgcacct
     3841 ttatccaaca tttcaaatag attttaaaag gaagatgtta gctttaaaaa cgtgctatga
     3901 taatgtactt gttagcacta cacactttgt acaaagaaaa acaagcaaga aaggtaggga
     3961 aatgaaagct tcctttgtgt acttttacac taagctgtgt tctgaaacat ggagataatt
     4021 tataagacca ctgtatgttc tatgtaaata aaaatgctgg tgtgaaatgg cattacggtt
     4081 tgccagtaag tgaattcttc ctgacttgcc gtaagagaga ggtttaaata ggtgcatctt
     4141 tgaaatatct gaatctactt cataatggaa cgatttaaat tgtactgcac caaaagtttt
     4201 atgccatttt tttaattaga taatcaccac caaggccttg ttacatcttt gtgtctacag
     4261 atgaagacag aaacttcttc caagtaatcc aaggatgaat gctgagaaca tgaactttgc
     4321 tgcaagacgt ctagaagctg atccacagtt tatgtttcac ccctatgtac attggggtgg
     4381 tgctatcttg atttttacag aaactgtttt tgagaattag cttgccttgt gtatacaaac
     4441 ctgaactagt ttgacttcaa aacttcctgt atcttttctg ttcttactga ctgcatactt
     4501 gatgagatac tttttgtttc tttggtttct taaaatatct gctataggaa cccactggca
     4561 aaaataggca gttatcagta aattattgaa acacagaaca aggaagtgga aaactgaact
     4621 ataaatgaag tctggtactg attgatgttt tgttttaaga aaaaactatt ttgtactaca
     4681 gtttctattg ggaaccactg ccatatctaa ctccttttta agaattctgt ttgcttggca
     4741 gcatcaatca gaagtttaac tttgtaacag atttctcaca tctaaacaga cattagaagc
     4801 ttggccagtt tgtacagcta tgtaacacaa ctgcaatcag gtgcttacct tacctcctgt
     4861 gttaacttta tacagtcatt tccactgcac cacttcttca gaccaaggag caagaaagat
     4921 cattcttgca taaagaaatg aactataatt aaatatcact ttattttgaa atgca
//
LOCUS       NM_001437715            5952 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus Cbl proto-oncogene B (Cblb), transcript variant
            3, mRNA.
ACCESSION   NM_001437715 XM_063270261
VERSION     NM_001437715.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5952)
  AUTHORS   Zhang,Z.Y., Bai,H.H., Guo,Z., Li,H.L., Diao,X.T., Zhang,T.Y.,
            Yao,L., Ma,J.J., Cao,Z., Li,Y.X., Bai,X., Chen,H.K., Suo,Z.W.,
            Yang,X. and Hu,X.D.
  TITLE     Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn
  JOURNAL   Sci Signal 13 (638) (2020)
   PUBMED   32606037
  REMARK    GeneRIF: Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5952)
  AUTHORS   Jeong,J.S., Kim,H.Y., Shin,B.S., Lee,A.R., Yoon,J.H., Hahm,T.S. and
            Lee,J.E.
  TITLE     Increased expression of the Cbl family of E3 ubiquitin ligases
            decreases Interleukin-2 production in a rat model of peripheral
            neuropathy
  JOURNAL   BMC Anesthesiol 18 (1), 87 (2018)
   PUBMED   30021515
  REMARK    GeneRIF: results suggest that ubiquitin and the E3 ubiquitin
            ligases c-Cbl and Cbl-b function as neuroimmune modulators in the
            subacute phase of neuropathic pain after nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5952)
  AUTHORS   Uchida,T., Sakashita,Y., Kitahata,K., Yamashita,Y., Tomida,C.,
            Kimori,Y., Komatsu,A., Hirasaka,K., Ohno,A., Nakao,R.,
            Higashitani,A., Higashibata,A., Ishioka,N., Shimazu,T.,
            Kobayashi,T., Okumura,Y., Choi,I., Oarada,M., Mills,E.M.,
            Teshima-Kondo,S., Takeda,S., Tanaka,E., Tanaka,K., Sokabe,M. and
            Nikawa,T.
  TITLE     Reactive oxygen species upregulate expression of muscle
            atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 314 (6), C721-C731 (2018)
   PUBMED   29513566
  REMARK    GeneRIF: Under microgravity conditions, elevated ROS may be a
            crucial mechanotransducer in skeletal muscle cells, regulating
            muscle mass through Cbl-b expression activated by the ERK-Egr
            signaling pathway.
REFERENCE   4  (bases 1 to 5952)
  AUTHORS   Li,P., Liu,H.L., Zhang,Z.Q., Lv,X.D., Chang,Y.X., Wang,H.J., Ma,J.,
            Ma,Z.Y., Qu,X.J. and Teng,Y.E.
  TITLE     Single nucleotide polymorphisms of casitas B-lineage lymphoma
            proto-oncogene-b predict outcomes of patients with advanced
            non-small cell lung cancer after first-line platinum based doublet
            chemotherapy
  JOURNAL   J Thorac Dis 10 (3), 1635-1647 (2018)
   PUBMED   29707316
REFERENCE   5  (bases 1 to 5952)
  AUTHORS   Li,P., Liu,H., Zhang,Z., Lv,X., Wang,H., Ma,J., Ma,Z., Qu,X. and
            Teng,Y.E.
  TITLE     Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma
            and Adenocarcinoma
  JOURNAL   Med Sci Monit 24, 623-635 (2018)
   PUBMED   29384143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5952)
  AUTHORS   Thirone,A.C., Carvalheira,J.B., Hirata,A.E., Velloso,L.A. and
            Saad,M.J.
  TITLE     Regulation of Cbl-associated protein/Cbl pathway in muscle and
            adipose tissues of two animal models of insulin resistance
  JOURNAL   Endocrinology 145 (1), 281-293 (2004)
   PUBMED   14525909
  REMARK    GeneRIF: CAP-Cbl pathway may have a role in the modulation of
            adiposity in fasting and in monosodium glutamate treated rats.
REFERENCE   7  (bases 1 to 5952)
  AUTHORS   Zhang,W., Shao,Y., Fang,D., Huang,J., Jeon,M.S. and Liu,Y.C.
  TITLE     Negative regulation of T cell antigen receptor-mediated Crk-L-C3G
            signaling and cell adhesion by Cbl-b
  JOURNAL   J Biol Chem 278 (26), 23978-23983 (2003)
   PUBMED   12697763
REFERENCE   8  (bases 1 to 5952)
  AUTHORS   Nishio,H., Otsuka,M., Kinoshita,S., Tokuoka,T., Nakajima,M.,
            Noda,Y., Fukuyama,Y. and Suzuki,K.
  TITLE     Phosphorylation of c-Cbl protooncogene product following ethanol
            administration in rat cerebellum: possible involvement of Fyn
            kinase
  JOURNAL   Brain Res 950 (1-2), 203-209 (2002)
   PUBMED   12231245
  REMARK    GeneRIF: c-Cbl protooncogene product is tyrosine- phosphorylated in
            rat cerebellum in response to ethanol administration.
REFERENCE   9  (bases 1 to 5952)
  AUTHORS   Yokoi,N., Komeda,K., Wang,H.Y., Yano,H., Kitada,K., Saitoh,Y.,
            Seino,Y., Yasuda,K., Serikawa,T. and Seino,S.
  TITLE     Cblb is a major susceptibility gene for rat type 1 diabetes
            mellitus
  JOURNAL   Nat Genet 31 (4), 391-394 (2002)
   PUBMED   12118252
  REMARK    GeneRIF: we report the positional cloning of Iddm/kdp1 and identify
            a nonsense mutation in Cblb, a member of the Cbl/Sli family of
            ubiquitin-protein ligases.Cblb is a major susceptibility gene for
            rat type 1 diabetes mellitus
REFERENCE   10 (bases 1 to 5952)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270261.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.30803.1,
                                           SRR26643292.45567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000011.1  62225753-62225896   c
            145-330             JAXUCZ010000011.1  62224275-62224460   c
            331-581             JAXUCZ010000011.1  62210550-62210800   c
            582-728             JAXUCZ010000011.1  62149944-62150090   c
            729-885             JAXUCZ010000011.1  62132129-62132285   c
            886-1007            JAXUCZ010000011.1  62127140-62127261   c
            1008-1145           JAXUCZ010000011.1  62123379-62123516   c
            1146-1233           JAXUCZ010000011.1  62121947-62122034   c
            1234-1365           JAXUCZ010000011.1  62119699-62119830   c
            1366-1569           JAXUCZ010000011.1  62109937-62110140   c
            1570-1755           JAXUCZ010000011.1  62099325-62099510   c
            1756-1850           JAXUCZ010000011.1  62090404-62090498   c
            1851-1997           JAXUCZ010000011.1  62081938-62082084   c
            1998-2095           JAXUCZ010000011.1  62079026-62079123   c
            2096-2236           JAXUCZ010000011.1  62076111-62076251   c
            2237-2356           JAXUCZ010000011.1  62070742-62070861   c
            2357-5952           JAXUCZ010000011.1  62058829-62062424   c
FEATURES             Location/Qualifiers
     source          1..5952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..5952
                     /gene="Cblb"
                     /note="Cbl proto-oncogene B"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
     exon            1..144
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            145..330
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2616
                     /gene="Cblb"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase CBL-B; SH3-binding protein CBL-B;
                     signal transduction protein CBL-B; casitas B-lineage
                     lymphoma proto-oncogene b; RING-type E3 ubiquitin
                     transferase CBL-B; Casitas B-lineage lymphoma b; Cas-Br-M
                     (murine) ecotropic retroviral transforming sequence b; Cbl
                     proto-oncogene B, E3 ubiquitin protein ligase; Cbl
                     proto-oncogene, E3 ubiquitin protein ligase B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-B isoform 3"
                     /protein_id="NP_001424644.1"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
                     /translation="MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRR
                     TVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLS
                     ENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAI
                     FPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKS
                     TIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY
                     STKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDG
                     RSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM
                     CTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLD
                     DDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVP
                     PRLDLIQKGIVRSPCGSPTGSPKVFSNGHLAPEEYDVPPRLSPPPPVTALLPSIKCTG
                     PIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCILNGT
                     HGTPSEMKKSNIPDLGIYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSS
                     GQDLFLLPSDPFFDPASGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQAPARP
                     PKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNLEVA
                     RSILREFAFPPPVSPRLNL"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    2458..2580
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    2458..2580
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    order(2464..2469,2473..2481,2485..2490,2503..2505,
                     2515..2517)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     misc_feature    order(2464..2469,2473..2481,2485..2490,2503..2505,
                     2515..2517)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     exon            331..581
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            582..728
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..885
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1007
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1145
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1233
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1365
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1569
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1755
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1850
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1997
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2095
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2236
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2356
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..5952
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttagctc cgccccacgc cttggtctcc ggggatggct caggggtggg gtggccagtg
       61 agtggtctcc tcctccggcg ggcgctgcgg cggcctcccg agagtggcgc gggactgccg
      121 ggcgggcgtg gagctgtctg cacgaaagga ctaagattcc agatggcaaa ttctatgaat
      181 ggcagaaatc ctggtggtcg aggaggaaac ccccgcaaag gtcgaatttt ggggattatt
      241 gatgccattc aggatgcagt tggaccccca aagcaagctg cagctgaccg caggacagtg
      301 gagaagactt ggaaactcat ggacaaagtg gtaagactgt gccaaaatcc gaaacttcag
      361 ttgaaaaaca gcccaccata tatcctcgac attttacctg atacgtatca gcatttgcgg
      421 cttatattga gtaagtatga cgacaaccag aagctggctc aactgagcga gaatgagtac
      481 tttaaaatct acatcgacag tctcatgaag aagtcaaagc gagcgatccg gctcttcaaa
      541 gaaggcaagg agaggatgta cgaggagcag tcgcaggaca gacggaatct cacaaagctg
      601 tcccttatct tcagtcacat gctggcagaa atcaaggcga tctttcccaa tggccagttc
      661 cagggagata acttccggat caccaaagca gatgctgccg aattctggag gaagtttttt
      721 ggagacaaaa ctatcgtacc atggaaagtc ttcagacagt gcctgcatga ggtccatcag
      781 atcagctctg gcctggaggc catggctctg aagtcaacca ttgacttaac ttgtaatgat
      841 tacatctccg tgtttgaatt tgatattttt accaggctat ttcagccctg gggctctatt
      901 ttacggaatt ggaacttctt agctgtgaca cacccggggt acatggcatt tctcacatat
      961 gatgaagtta aagctcgact acagaaatac agcaccaagc ctggaagcta cattttccgg
     1021 ttaagctgca ctcggctggg acaatgggcc attggctatg tgactgggga cggcaatatc
     1081 ctacagacca tacctcataa taagcccctg ttccaagccc tgattgatgg tagcagggaa
     1141 ggcttttacc tttatccaga tggacgaagc tataaccctg atttaaccgg attatgtgaa
     1201 cctacacctc atgatcatat aaaagttaca caggagcaat atgaactgta ttgtgaaatg
     1261 ggctccactt ttcagctgtg caagatctgt gcagagaatg acaaagatgt caagatcgag
     1321 ccttgcgggc atctcatgtg cacttcgtgc cttaccgcgt ggcaggagtc tgatggccaa
     1381 ggctgcccct tctgtcgctg tgagataaaa ggaaccgaac ctatcatcgt ggatcccttt
     1441 gaccccagag acgaaggctc caggtgctgc agcatcatcg accctttcag catccccatg
     1501 ctcgacttgg atgatgacga tgatcgagag gagtctctga tgatgaaccg gctggcgagt
     1561 gttcgcaagt gcacagacag gcagaactcg ccagtcacat cgccaggatc ctcacccctt
     1621 gcccagagaa gaaagcctca gccagaccct ctccagatcc cccacctcag cctgccacca
     1681 gtgcctcccc gcctggacct cattcagaaa ggcatcgtgc gctctccctg tggcagcccc
     1741 acgggctccc cgaaggtctt ttccaatgga caccttgccc ctgaagaata cgacgttcct
     1801 cctcggcttt cccctcctcc tccagtcact gcccttctcc ctagcataaa gtgtactggt
     1861 ccaatagcaa attgtctctc cgagaaaaca agagacacag tagaagaaga tgatgatgaa
     1921 tacaagattc cttcatccca tcctgtttcc ctgaattcac aaccatctca ttgtcataat
     1981 gtcaaacctc ctgttcggtc ttgtgataat ggtcactgta tactgaatgg aactcatggt
     2041 acgccttcag agatgaagaa atcaaacatc ccagatttag gcatctattt gaagggtgaa
     2101 gatgcttttg atgccctccc cccatccctt cctcctcctc cacctcctgc aagacatagt
     2161 ctcatcgagc attcaaaacc tccaggctcc agtagccggc cttcctcagg acaggacctt
     2221 ttccttcttc cttcagatcc cttttttgac ccagcaagtg gccaagttcc attgcctccg
     2281 gccaggagag caccaggaga tggtgtcaaa tccaacagag cctcccagga ctatgaccag
     2341 ctcccttcat cttccgatgg ttcgcaagca ccagctagac cccccaaacc acgaccccga
     2401 aggactgcac cagaaattca tcacagaaag ccccatgggc ccgaggcggc actggaaaat
     2461 gtggatgcga aaattgcaaa actcatggga gaggggtatg cctttgaaga ggtgaagaga
     2521 gccttagaga tcgcccagaa taacctggaa gtggccagga gcatacttcg agaattcgcc
     2581 ttccctcctc ccgtctcgcc acgtctcaat ctatagcagc ccagactgca aacaccaaag
     2641 ggtaaaacag ttaacaaata ttccaggagt atgggacgga aggactgaga gggaatgcag
     2701 gagccatggt gtcttttcat gtggcgtctc cagaaggcag ccttgagtcc agcttctctg
     2761 gtaccacagc tccctgagga tgcccacgct gcagcttctg tgtttgtgct agccatactt
     2821 ttaaatcagg gttgaactga gaaaataatt taaagacgtt tactccccct tgaactttga
     2881 atctgtgaaa tgctttcctt gtttacacgt tggcagaatt gcagtttgtc tctgtttttg
     2941 attcctgtac tgtgttcctg acaggccctt ggcagagttg gtcaggtctg ctgtaagttt
     3001 gtccatgccc accctgctgc ccacattggc agctaaagca tctcttcgtg ttgctgtcta
     3061 tccgggcccc acctcatgtg tccacgtcca gttcatttct ctcattcaca cagcatgcta
     3121 gtctgaggtc ctgatttttc atcgttttaa actaatgcag aaagaaaaag aaaaagaaaa
     3181 aaaatgtatg tggtctggtc ttcactactg agtctcttct ttgggaacca tcactgttga
     3241 gaggtgggga aacctgaatg taaaaagcat ttatttgtca ataaactgcc ttttgtaagg
     3301 ggtttttata tactgtaaaa gagcttccct tgttagttta agttctgtga cctttaggtt
     3361 tctgtacact ccctcccgtc cgcccaggag tgccatgaca gatgcaggag aaaatggggc
     3421 agcgcccgta ctacaggacc gtaatgagat tctctgatag ttatgcctcc atcactttca
     3481 ggagagatgg aaaggggggc caccgcctcg aaatatgtta atatgccttt agataaggtc
     3541 atagacatac atgcctttcc caagtggaag agagcccctt ttctatgtta tgacatcacc
     3601 ctggctcctc cctgtgtggg agcccctaag gcactgatga ctgttatgta tcactgctac
     3661 tgcaggcctt cttacttgca aaactcttcg taccctttct ccagtcaggt taggagtccc
     3721 gtttactctg tgggttttct cattgactgc tccgtgttgc ccgtcccagt cagatgaaac
     3781 cgtggtatca ctttaaatct acagataccc cttgaccatc tgtaaagtgc tttgcactct
     3841 tgttggcttt gaaagcacaa aatttcacac atgaactccg ccatattatt tgtgtatatg
     3901 tgtttggtgg taaatgtctc caatctgatg gatgaatcct ctgagactga tgcgaggact
     3961 tttagacctt cagattgctt ttgttttgtt ttgttttgtt ttgttttgtt ttttgcatcc
     4021 ctaatagtgt gtgaggggaa ataaaagcca tctccatgca aaaatgcttg cacgacattt
     4081 tgatagtttc taaagatgga ttcagttgta ggttgcatgg gtgtctctta cccctcctta
     4141 ctccacaccc agagatgcct cagataatca ctccctcatc ctgacaaagg acaagatact
     4201 acagcagata gatccgatgc agctgccatt ttatgagagt catgtccaca gctgtgtttg
     4261 cccagaaagg ggaacgtgcc cagcatactc gtttgcagtg tggctttcat gggatgagac
     4321 aggacttgag gatcacagtc tttgcatatg tcaggtttgt tcagagggcc ctatgtttct
     4381 tctgctacca cagggggatt ttttaatgtt tttacatcct atacctggga ggaggtatga
     4441 atacaaggtt tttttttaat atacttttta caattggctc tttgttgttt tattatctgc
     4501 tcttaatttt ttttacttgt tttataagtt ctgatgtcat actgatagat aacagtgcta
     4561 tgttttttgg ggggtttcac acaacttgcc aacaatcggc atagcctaaa acccaaagtt
     4621 tgccccttcg ttgtcctaac actgttaaac atccttaaac tacgaggggg ttggtttaca
     4681 acaggagcac tgggacccac agcatattct cctgcactct cgcataacac aagagatttc
     4741 cgtcaagaat ttaaaggcta aagatgtgct caaacagttg atttggacct gaggtttagg
     4801 gagggaggga agtgtaaata attttctgga ttgtaccaag atctctgctg catccacaca
     4861 gtagccactg ccggttttct catcaagaaa agtgaacctt gtgactcata cggaagacag
     4921 agcaaacaga aagcataaag actcacagaa tttgtttgag aacagtagtt caaactcttt
     4981 ttcattagga aagggactac tagttaatac tttgaaatgt cccatacttt gttccctctt
     5041 tttccagaaa ttgagatgtg cctcccaatg ctcaagattt gataatagaa ttacccttaa
     5101 gccagtattt aatataatct acacaattaa aacaaaccac ggctaattgg aacctctgcc
     5161 cgggatctat ccccaatgat attccagtcg tggtttttcc agaattctgg aggatttttt
     5221 tcctatttcc ttttcctttt aacccaccac acctacaccc ccaccccaac ccataacccc
     5281 acatccgaac caccaccaac ttcttggtat ctgatctatc acagccaaat tttctggacc
     5341 cagatcccaa cattttgatg cttaacttaa tcttgcaccc acaattaaaa ttattagccc
     5401 ttttctacct tccctctgcc cacagtacaa cacagagccc tagccagagc ctccagaggt
     5461 ctgtttgcta actcagtatt tcgcacaccc aaggacacat gcaaagagtt cttcataatg
     5521 tgaactttct aattgttcag ttccagaagc atttcctgca gtttgaacgt gactttgcct
     5581 ctcggatttt caacttgaag ctttagtttg cactgaatta tttcatctgg ttttaaaatg
     5641 tctcaaatgg actgatttgg aaacaaaatg tggtatattt taaatattga tggaggtact
     5701 ttctgtaaac ctgaaatgtt agagctccga ggaagacttt ccggaaaaag acagcaatag
     5761 aaagaaagtt ttcttctcag ttcctatttt tattgttttt gaaatgcatt ttttaaaaac
     5821 ttgtctaatg tggcaaaata gctatgtgat caattaattt atattttatt cattcttttt
     5881 caattctgga tatgtaacct caagtacttt atctgttctt ttaaggtatt ttataaaatg
     5941 aatgttgaca aa
//
LOCUS       NM_001437686            5020 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 6,
            mRNA.
ACCESSION   NM_001437686 XM_039087892
VERSION     NM_001437686.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5020)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5020)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 5020)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 5020)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 5020)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5020)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 5020)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 5020)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 5020)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 5020)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087892.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.67896.1,
                                           SRR26360176.219734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-423             JAXUCZ010000011.1  98104416-98104454
            424-470             JAXUCZ010000011.1  98105694-98105740
            471-542             JAXUCZ010000011.1  98106090-98106161
            543-629             JAXUCZ010000011.1  98108322-98108408
            630-792             JAXUCZ010000011.1  98109928-98110090
            793-913             JAXUCZ010000011.1  98113029-98113149
            914-1045            JAXUCZ010000011.1  98115531-98115662
            1046-1252           JAXUCZ010000011.1  98117537-98117743
            1253-1373           JAXUCZ010000011.1  98123938-98124058
            1374-1529           JAXUCZ010000011.1  98124251-98124406
            1530-1619           JAXUCZ010000011.1  98124558-98124647
            1620-1712           JAXUCZ010000011.1  98126328-98126420
            1713-1769           JAXUCZ010000011.1  98128415-98128471
            1770-1847           JAXUCZ010000011.1  98129086-98129163
            1848-2042           JAXUCZ010000011.1  98131039-98131233
            2043-2152           JAXUCZ010000011.1  98131384-98131493
            2153-2312           JAXUCZ010000011.1  98133415-98133574
            2313-5020           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..5020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5020
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2369
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 6 is encoded by transcript variant 6;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 6"
                     /protein_id="NP_001424615.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEE
                     WGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDL
                     PGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDP
                     DGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIR
                     DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNS
                     YGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLE
                     SVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHE
                     EMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYIN
                     TKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASA
                     EADGKVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPAS
                     PQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFL
                     VNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRE
                     THLW"
     misc_feature    135..137
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    306..314
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    906..917
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1203..1640
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Middle domain.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1758..1760
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1815..1817
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1911..1913
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1914..1916
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1947..1949
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q8K1M6; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    1977..1979
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2004..2006
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:17301055,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2067..2069
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CAMK1 and PKA.
                     /evidence=ECO:0000269|PubMed:28463107; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2076..2348
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2076..2348
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2118..2162
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Important for homodimerization.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..423
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..470
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..542
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..629
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..792
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..913
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1045
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1252
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1373
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1529
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1619
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1712
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1769
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1847
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2042
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2152
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2312
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..5020
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatgaccctg ctacatggaa aaactcaaga cacctttcta
      421 aaggagttga agcagaagaa tggggtaaat ttcttcacac caaaaacaag ctttacacag
      481 attttgatga aattcgacaa gaaattgaaa atgaaactga aagaatttca ggaaataata
      541 agggagtaag ccctgagcca atccatctca aggttttctc gcccaacgtt gtcaacctga
      601 cgcttgtgga tttaccagga atgaccaaag tacctgtagg tgatcagccc aaggatattg
      661 agcttcaaat cagagaactt attcttcggt tcatcagtaa tcccaattcc attatccttg
      721 ctgtcactgc tgcaaataca gatatggcaa cgtcagaggc acttaagatt tccagagagg
      781 tagatccaga tgggcgcaga actctagctg taatcaccaa gcttgatctc atggatgcgg
      841 gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaagctt ggaataattg
      901 gagtagttaa caggagccaa ctggacatta acaataagaa gagtgtaact gattcaatcc
      961 gtgatgagta tgcttttctt caaaagaagt acccatctct ggccaacaga aatggaacaa
     1021 agtatcttgc taggactctg aataggttac ttatgcatca tatcagagac tgtttaccag
     1081 agctgaaaac aagaataaat gtcttagctg ctcagtatca gtctcttcta aatagctatg
     1141 gtgagcccgt ggatgataaa agtgctactt tactccagct cattaccaag tttgccacag
     1201 agtattgtaa cactattgaa ggaacggcaa agtacattga aacttctgag ctatgtggtg
     1261 gtgctaggat ttgttatatt ttccatgaga cttttgggcg aaccttagaa tctgttgatc
     1321 cactaggtgg ccttaacact attgacatct tgaccgccat tagaaatgct actggccccc
     1381 gtccagcttt atttgtgcct gaagtttcat ttgagttact ggtcaaacgt cagattaagc
     1441 gtctagagga gcccagcctc cgctgtgtgg agctggtcca cgaggaaatg cagaggatca
     1501 ttcagcactg tagcaactac agcacacagg aactgttacg gttccctaaa ctccatgatg
     1561 ccatagttga agtagtgact tgtcttcttc gtaaaaggtt gcccgtgaca aatgaaatgg
     1621 tacataactt agtggcaatt gagctagcat atatcaacac aaaacacccc gactttgctg
     1681 atgcctgtgg gctaatgaac aataacatag aggaacaaag aagaaacaga ctagcaagag
     1741 aactaccttc cgctgtatcg cgagacaagt cttctaaagt tccaagtgct ttggcacctg
     1801 cctcccagga gccctcccct gccgcttctg ccgaggctga tggcaaggtt gcatctgcag
     1861 gtggtggaat tggagatggt ggtcgaattg gagatggtgg tcaggaaccg acaacaggca
     1921 actggagagg aatgctgaaa acttcaaaag ctgaagaatt acttgctgaa gaaaaatcaa
     1981 aaccaattcc aattatgcca gcaagtccac aaaaaggcca tgctgtcaat ttgctagatg
     2041 tgccagttcc agttgcacga aaactgtctg cccgagaaca gcgagattgt gaggttattg
     2101 aaagactcat caaatcatat tttctaattg tcagaaagaa tattcaagac agcgtcccaa
     2161 aggcagtaat gcattttttg gttaatcatg tgaaagatac tcttcagagt gaattagtag
     2221 ggcagctgta taagtcatcc ttattagatg accttctgac tgaatccgag gacatggcac
     2281 agcgaagaaa agaagcggct gacatgctga aggcattaca aggagccagt caaattattg
     2341 ctgaaatccg agagactcat ctttggtgaa cagaactgtt tggtcttcta cactttgctg
     2401 acttgaacct actagctact gcctacctga gtagaaattt atttatggac ttttgtgtat
     2461 cgcagtgtat gaatttgctt gtgtgaagac tggctataag ctgaaaagta tattattcat
     2521 tacaagacaa atcacatgtt taattcacat ttttcaagtt tcctatgatg tatatcaagt
     2581 ctgtccgttt cagtcaaact tacaagaaca attgatgttc tagttgtaca aagcagtttg
     2641 cctgtgcata tgatgacctg cgtaaccttt ttttagtctt aaagctgcag ccgtagtcct
     2701 caaagaggaa gctccaggac atttcatgac tataatgcat gcactattta tatagactga
     2761 cctggcttca aaaggtggag cctggcgagt tcctcacata atcaatgtat ccacctatcc
     2821 ttcattttta tagtcttaaa aaacaaacaa aattctgaaa cttctgcagt tttaggaaaa
     2881 atataagatc tgaaagactc ataaagatgt aggaacagac tgtgtaatta atggctcctg
     2941 agtctatact gccctaatgt tagaaagtaa aatatgcttt gattcaaaat aagcctgaaa
     3001 atataaattg acttcctgca ttaaaaataa ctattaggaa ctttcttagt aacaataact
     3061 ggtcctgtta gtttctaaat gactcagtga caacctaaat ttccctaatt tacaagtaca
     3121 tcgattgcag tccagatgca ccttagggtg gggcgctgac tctgggctcc gagactcagt
     3181 tatgtgagac ctaaaagtct actctgtatc cactggtaat gctactttat agttccacac
     3241 caacagaata catttgtcaa agaaaaatac ctggacatac acatacacct aaaagcttat
     3301 ggactactaa actgtattca ggggttgagg atttacaacc tattttgtga aaactgcctg
     3361 tgcaattcaa tttctgacct agctgggcag tggtggtgca cacctttaat cccagctttt
     3421 gggaggcaga ggcaggtgga tctctgagtt caaggccagc ctggtctaca gagttgagtt
     3481 ccaagacaac cagaactaca cagagaaacc ctgtcttgaa cccccctccc cccaaaaaat
     3541 tgaaacctaa atagaaatct ttgatgtatc tagttttctc tgaccaaatg atacatttgt
     3601 gttataaata ctaaaattct tttcaggtca ggcatcttat gaaatactat tagcaaggaa
     3661 aacaagaaca tgttatcttt agtttagatg cccattgaac catctcaaaa acaaaggcag
     3721 tctgataaca gtaccagctt gacagtgagt atacactgcc taaatgtgtt agcatactta
     3781 agaaaaatat cctgttatct aactattagg tatccatggt ttatttttta agagagatga
     3841 ccaccactgt agccttttga atttgtaaag agaaagaatg cacctttatc caacatttca
     3901 aatagatttt aaaaggaaga tgttagcttt aaaaacgtgc tatgataatg tacttgttag
     3961 cactacacac tttgtacaaa gaaaaacaag caagaaaggt agggaaatga aagcttcctt
     4021 tgtgtacttt tacactaagc tgtgttctga aacatggaga taatttataa gaccactgta
     4081 tgttctatgt aaataaaaat gctggtgtga aatggcatta cggtttgcca gtaagtgaat
     4141 tcttcctgac ttgccgtaag agagaggttt aaataggtgc atctttgaaa tatctgaatc
     4201 tacttcataa tggaacgatt taaattgtac tgcaccaaaa gttttatgcc atttttttaa
     4261 ttagataatc accaccaagg ccttgttaca tctttgtgtc tacagatgaa gacagaaact
     4321 tcttccaagt aatccaagga tgaatgctga gaacatgaac tttgctgcaa gacgtctaga
     4381 agctgatcca cagtttatgt ttcaccccta tgtacattgg ggtggtgcta tcttgatttt
     4441 tacagaaact gtttttgaga attagcttgc cttgtgtata caaacctgaa ctagtttgac
     4501 ttcaaaactt cctgtatctt ttctgttctt actgactgca tacttgatga gatacttttt
     4561 gtttctttgg tttcttaaaa tatctgctat aggaacccac tggcaaaaat aggcagttat
     4621 cagtaaatta ttgaaacaca gaacaaggaa gtggaaaact gaactataaa tgaagtctgg
     4681 tactgattga tgttttgttt taagaaaaaa ctattttgta ctacagtttc tattgggaac
     4741 cactgccata tctaactcct ttttaagaat tctgtttgct tggcagcatc aatcagaagt
     4801 ttaactttgt aacagatttc tcacatctaa acagacatta gaagcttggc cagtttgtac
     4861 agctatgtaa cacaactgca atcaggtgct taccttacct cctgtgttaa ctttatacag
     4921 tcatttccac tgcaccactt cttcagacca aggagcaaga aagatcattc ttgcataaag
     4981 aaatgaacta taattaaata tcactttatt ttgaaatgca
//
LOCUS       NM_001437751            3837 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 9 member C1 (Slc9c1),
            transcript variant 5, mRNA.
ACCESSION   NM_001437751 XM_039088182
VERSION     NM_001437751.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3837)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   2  (bases 1 to 3837)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039088182.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.69084.1,
                                           SRR26360181.2694227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000011.1  68740757-68740859   c
            104-234             JAXUCZ010000011.1  68739393-68739523   c
            235-488             JAXUCZ010000011.1  68738514-68738767   c
            489-589             JAXUCZ010000011.1  68737292-68737392   c
            590-718             JAXUCZ010000011.1  68735441-68735569   c
            719-884             JAXUCZ010000011.1  68734127-68734292   c
            885-1010            JAXUCZ010000011.1  68731230-68731355   c
            1011-1172           JAXUCZ010000011.1  68729739-68729900   c
            1173-1272           JAXUCZ010000011.1  68727024-68727123   c
            1273-1416           JAXUCZ010000011.1  68725462-68725605   c
            1417-1591           JAXUCZ010000011.1  68724252-68724426   c
            1592-1673           JAXUCZ010000011.1  68722851-68722932   c
            1674-1840           JAXUCZ010000011.1  68721131-68721297   c
            1841-1966           JAXUCZ010000011.1  68719387-68719512   c
            1967-2064           JAXUCZ010000011.1  68710052-68710149   c
            2065-2184           JAXUCZ010000011.1  68707948-68708067   c
            2185-2380           JAXUCZ010000011.1  68705164-68705359   c
            2381-2530           JAXUCZ010000011.1  68700108-68700257   c
            2531-2582           JAXUCZ010000011.1  68698708-68698759   c
            2583-2731           JAXUCZ010000011.1  68697254-68697402   c
            2732-2857           JAXUCZ010000011.1  68693952-68694077   c
            2858-2956           JAXUCZ010000011.1  68692683-68692781   c
            2957-3139           JAXUCZ010000011.1  68689006-68689188   c
            3140-3271           JAXUCZ010000011.1  68682499-68682630   c
            3272-3457           JAXUCZ010000011.1  68682196-68682381   c
            3458-3584           JAXUCZ010000011.1  68680194-68680320   c
            3585-3637           JAXUCZ010000011.1  68676184-68676236   c
            3638-3837           JAXUCZ010000011.1  68674380-68674579   c
FEATURES             Location/Qualifiers
     source          1..3837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3837
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
     exon            1..103
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            104..234
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            235..488
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    326..328
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="upstream in-frame stop codon"
     CDS             341..3700
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="isoform 2 is encoded by transcript variant 5;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; solute carrier family 9, member 10; solute
                     carrier family 9, subfamily C (Na+-transporting carboxylic
                     acid decarboxylase), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 10 isoform 2"
                     /protein_id="NP_001424680.1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
                     /translation="MEEVFENLTTTHNVKLSNAWLDLLKSVFLSTPQDLPEIILILSL
                     ICTIGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFFGI
                     FTPVIIFNVAFDMDIYMLQKLFWQILLITIPGFMINYTLILWYLQSVNKLSLKTIPWL
                     LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKH
                     MNHTLAHKVMSTAWSYLVESFITGILITKAIQLWMATIFGDDVNHITLIFSVLYLIFY
                     VCELIGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPA
                     HTYLYISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKG
                     TPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIVNRFILPMAVIKLGLRDVT
                     STKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTE
                     HQKVKCPDCNKEIDETLNIEAMELANRRLLSAQIASYQRQYRNEILSQSAMQVLVGAA
                     GSFGEKKGEYMSPENIKNYSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHS
                     IVFTNEFEYTGYIAVLMNTYPMIICWISRLKDIYQYEIKCANYYFLTFYILEALLKLI
                     TPKLLQVIDKRMSQQISFRYAILKGYVQGEMDVLNIIDQIASSKQAKQILLKRVIRNM
                     DHAMKELGYLEYDHPEIAVTMKTKEEVNVMLNMAREIVKAFRSKGIIHKVEGAEINKL
                     IMAKKKQVLELQSVIQPLNVEEAPYYIPWLSEDPEAISFIQEKAKVVTFDCGNNIFEE
                     GDEPEGIYVIISGMVKLKRSKPHLEMDRVSSESEVAQTRSYTLPHTEYLLSGEIIGEL
                     NCLTKERMQYSATCKTVVETYFIPISHLYEGFEKKYPNMKYKMWQKIGLAITAQKIRE
                     NLSFEDWNYKMQLKLCNVFVRDIPKTTKTDIYDETVTHVVLIHGSAEDCQLRKIYKAP
                     FLIPVTCHQIQGLEEFTKVMIIQTSVAVRKFRWNVKKYNPPRRISMKPDSTESLETLN
                     ESSEDDEDKKENEENEEYLEDIIDISSVSKK"
     misc_feature    449..2008
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    449..2008
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    2831..3214
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    2831..3214
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(3074..3079,3104..3112)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3074..3079,3104..3112)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3170..3178,3191..3199)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3170..3178,3191..3199)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            489..589
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            590..718
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            719..884
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1010
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1172
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1272
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1416
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1591
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1673
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1840
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1966
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2064
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2184
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2380
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2530
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2582
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2731
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2857
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2956
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3139
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3271
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3457
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3584
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3637
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3837
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtcagt gaggttgcag ttggttttgg acagttctgg agtgagagga agttcctggc
       61 ctccacttct cacattctct aggacactcc tgtgccctgg atgctttcca agtgattcat
      121 gctactgctg agatggagtc ttactggaca gacatagctg agagccgttg ctctatttcc
      181 agatcaacct caagctcttg ttttcttttg tgattttttt tttattattt tgagaagggc
      241 attaggaaga caccaagaag aaaagtccta ttccctttga tcccctgtga gtttttcaga
      301 gacacagagt ttgagacgct gactgtaatt aaatacggga atggaagaag tttttgagaa
      361 tctaactaca acccacaatg tcaaactgag taatgcatgg ctggatcttc tcaaaagcgt
      421 gtttttgagc actccccagg acctccctga aatcatcttg atactatctt tgatctgtac
      481 gattggagca tttttgaaca tgcatctgaa ggattttcca attcctcttc ctgtgatact
      541 atttttaatt ggatgctgtt ttgaaattct gagttttgca tctactcaga tccagttata
      601 tgcagatgcc atacagtgga tggatcctga catgtttttt gggatattta caccagtaat
      661 tatctttaat gttgcatttg acatggatat atacatgctt caaaagttat tttggcagat
      721 attattaatt acaattcctg gatttatgat taattacacc ttaatactgt ggtatctgca
      781 gtctgtgaat aaattatctt taaagaccat cccctggcta ctgttttcag ctgtgcttat
      841 cagttcagat cctatgctta cttcagcctc cataagagac cttggtcttt ccagaagcct
      901 cacaaattta attaacggag agagtctact gacctcagtg atatccttaa ttatatatag
      961 tgctgttgtg cagatcagtt tcaagtcaaa gcatatgaac cataccctag cccataaggt
     1021 catgtccaca gcttggtcat atcttgtgga aagtttcatc actggaatcc taattacaaa
     1081 agcgattcag ttatggatgg ctaccatctt tggtgatgac gtcaaccaca tcacgctcat
     1141 cttctcagtt ctatacctca tcttctatgt ttgtgagcta attggaatgt ctggaatatt
     1201 tactctggcc accataggac tttttctaaa ttctacaagt tttaaaccag gagttgaagc
     1261 atttctcctc gaattctgga actgcctgtc ctttattggt ttccttatgg tgttcacttt
     1321 cattggactt ctaatccctg cacacacata tttatatata tcattttctg atgtgtatta
     1381 ctcattaaat atctacttca cgctgattgt tttaaggctt ctggtctttc tgctaatgag
     1441 ccccattttg tctcgacttg gtcacgggtt cagctggcgc tgggcgttca tcatggtctg
     1501 gagtgaaatg aaaggaacac cgaacataaa tatggccctt ctgcttgcct actcggacgt
     1561 ttctcttggt tccgagaggg aaagatctca aatattattc catggcgtgt cagtatgtgt
     1621 aatcaccctg attgtcaata gatttatttt gccaatggca gtaattaaac taggtcttcg
     1681 tgatgtcaca tcaacaaaat ataaatcggt ttattataca ttccagcact ttcaagagct
     1741 aaccaaatcc acagccatgg cactcaaatt tgacaaagat cttgctaacg ctgactggaa
     1801 catggttgac aaggcgatta tacttcaaaa tccatatgct ttaaaccaag aagaaacaac
     1861 ggaacatcag aaggtgaaat gtcctgattg caacaaggaa atagatgaga cccttaacat
     1921 tgaagccatg gagttggcca acaggcgtct cctgtcagcg caaatagcaa gctaccaacg
     1981 acagtacagg aatgagattc tgtcccagag tgcaatgcaa gtgttggtag gcgcggccgg
     2041 aagctttggt gagaagaagg gagaatatat gagtcctgag aacataaaga attattcaga
     2101 aagcaaaaaa ctcctctcct ttcttagaaa attactactc aactgggtat ataatactaa
     2161 aaaagataaa ggggttccat caagatacat gtttcttcat gcatgccata gcatagtctt
     2221 cacaaatgaa tttgaataca ctggatacat cgctgtatta atgaacacat atccgatgat
     2281 aatctgttgg atttcccgac taaaagacat ctatcaatat gagataaaat gtgctaacta
     2341 ctattttctt acattttata ttctagaggc tctacttaag cttataacac caaaattgct
     2401 gcaagtaata gacaaaagga tgagccagca gatatccttc cggtatgcta tactaaaagg
     2461 ctacgtccaa ggggaaatgg atgtactgaa tataattgat cagattgcaa gttccaaaca
     2521 ggctaaacag atattgttaa agcgagtaat aaggaatatg gatcatgcta tgaaagagct
     2581 gggctaccta gagtatgatc acccagaaat cgctgtcact atgaaaacca aggaggaggt
     2641 taatgtgatg ctcaatatgg ccagagaaat tgtcaaggct ttcaggtcca aaggaattat
     2701 acataaggtg gaaggcgctg agatcaacaa gttaatcatg gccaaaaaga aacaagtgct
     2761 tgagctgcag tctgttatcc agccacttaa tgttgaagaa gccccatact atatcccatg
     2821 gctcagtgaa gatcctgaag ccataagctt tattcaggaa aaagcaaaag ttgtgacatt
     2881 tgactgcgga aataacatat ttgaggaagg cgacgaacca gaaggaatct atgtaataat
     2941 ttcgggcatg gtaaagctta aaaggtcaaa gccacacctg gagatggata gagtgtcctc
     3001 agagtcagag gttgctcaga ctagaagtta tacactgcct cacacagaat atctgctcag
     3061 cggggaaata ataggagagt taaactgttt gactaaagaa cggatgcaat attctgccac
     3121 ctgcaaaact gttgtggaga cgtattttat tcccattagc cacttgtatg aaggctttga
     3181 aaaaaaatac cctaacatga aatataaaat gtggcaaaaa atcggacttg ccattactgc
     3241 ccaaaagatc cgggaaaact tatcttttga ggactggaac tacaagatgc agttgaaact
     3301 ctgcaatgtc ttcgtaaggg acatacccaa gaccacaaaa actgacatct atgatgaaac
     3361 ggtaacccat gttgtcctca tccatggatc tgcagaagac tgccagttgc gaaaaattta
     3421 taaggcacct ttcctaattc ccgtgacatg ccatcagata caaggcttag aagagttcac
     3481 aaaagtcatg attattcaaa cttccgttgc tgtgagaaaa ttcaggtgga atgtaaaaaa
     3541 gtacaaccca cctcgaagga tttcaatgaa accagattct acagaatcac ttgaaacatt
     3601 aaatgaaagt tctgaagatg atgaggataa aaaagagaat gaagaaaatg aggaatattt
     3661 ggaagatatt attgacatct caagtgtctc caagaaataa cctggaaaga aagtttagtc
     3721 agtcgcctga gcttctcacc atggcaatga aaacatatat ttatggagat agagacaagc
     3781 caaagtttat atgcctcttg tgtgataatg tgaattaaag taccttgcac tagtcaa
//
LOCUS       NM_001437706            3026 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 4, mRNA.
ACCESSION   NM_001437706 XM_063270256
VERSION     NM_001437706.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270256.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.42961.1,
                                           SRR26643292.45364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000011.1  48251487-48251658   c
            173-390             JAXUCZ010000011.1  48198562-48198779   c
            391-542             JAXUCZ010000011.1  48179141-48179292   c
            543-746             JAXUCZ010000011.1  48168955-48169158   c
            747-827             JAXUCZ010000011.1  48168156-48168236   c
            828-884             JAXUCZ010000011.1  48158140-48158196   c
            885-932             JAXUCZ010000011.1  48157502-48157549   c
            933-3026            JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3026
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..172
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     CDS             155..1453
                     /gene="Erg"
                     /note="isoform 4 is encoded by transcript variant 4; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 4"
                     /protein_id="NP_001424635.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGM
                     SYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSD
                     SSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKV
                     HGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALP
                     VTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    941..1192
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    941..1192
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            173..390
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            391..542
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            543..746
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            828..884
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            885..932
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            933..3026
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatagaaacc tcttcctgcc attggctgac ttcatttccc agacttagca caatctcatc
       61 cgctctaaac aacctcatca aaactacttt ctggtcagag agaagcaata attattatta
      121 acatttatta acgatcaata aacttgattg cattatggcc agcactatta aggaggcctt
      181 gtcagttgtg agcgaggacc agtcactatt tgagtgtgcc tacggaacgc cacacctggc
      241 taagacagaa atgaccgcat cctcttccag tgactatggc cagacatcca agatgagtcc
      301 cagagtccca caacaggact ggctgtctca gcccccagcc agggtcacca tcaagatgga
      361 gtgcaaccct agccaggtga acggttccag gaactcacct gacgaatgca gtgtgaccaa
      421 aggtgggaag atggtgggca gccctgatac tgtgggaatg agctacggca gctacatgga
      481 ggagaagcac atgccgcccc ccaatatgac cacgaatgaa cgcagagtga tcgtccctgc
      541 agatcctact ctgtggagca cagaccatgt ccggcagtgg ctggagtggg cagtgaaaga
      601 atacggcctc ctagacgtgg acgtcttatt atttcagaat attgacggga aggagctgtg
      661 caagatgaca aaagatgact tccagaggct cactccgagc tacaatgccg acattcttct
      721 ctcacatctc cactacctca gagagactcc ccttccacat ctgacatccg acgacgttga
      781 taaggcttta caaaactctc cacggttaat gcatgctaga aacacagctg cccagccatc
      841 tccctccaca gtgcccaaaa ctgaagacca gcgtcctcag ttagatcctt accagatcct
      901 gggacccacc agtagtcgcc ttgctaatcc aggtagtggc cagatccagc tgtggcagtt
      961 cctgctagaa ctcctgtctg acagctccaa ctccaactgc atcacctggg aaggcaccaa
     1021 cggggagttc aagatgacag acccggatga ggtggctcgg cgctgggggg agcggaagag
     1081 caagcccaac atgaactatg acaaactcag ccgtgccctc cgctactact acgacaaaaa
     1141 catcatgacc aaggtgcatg ggaagcgcta tgcctacaag tttgacttcc acgggattgc
     1201 ccaggccctg cagccccatc cccccgagtc gtccctgtac aagtacccct ccgacctgcc
     1261 gtacatgggc tcctatcaca cccaccccca gaagatgaac tttgtggctc cccaccctcc
     1321 ggccctccca gtcacatctt ccagtttctt tgctaccccg aacccatact ggaattcgcc
     1381 gactgggggc atctacccga acactaggct cccagccagc catatgccct ctcacctggg
     1441 cacctactac tagagaccag atagaggcct ttcccaacag tgcacaatcg cctagcaatc
     1501 accacaaact cagagaacac aaatcgaaag tgcctcctga ggaatggaaa cggttggcca
     1561 gagctgggga aggaagccgg ggaaagaaaa ccaaagactc acaggggagg gtgggcacca
     1621 cccaagtatt actacagaaa tagaagaagc tcaaaatata ctgtacatgg acatataacc
     1681 tgtggtccac ccttgtcaaa gacattgtat gtagaaaagc gtgaccgaga agaacaactg
     1741 tccaaggaag tggccttaag tagtgtacaa actgtagagt gtgggacctt gcttgtacca
     1801 ggattcagtg agagcaatag aaccataaca gtcttggcct agcacaccat cacgtgtgat
     1861 gacatttgaa gggaaactac ctgtgtttaa aaacagaaaa aaacatatcc aaaccaaata
     1921 agaagaggaa aaaaaaaaaa agatggcggc ccctccacag accacaatgg ctgtggattt
     1981 tcttggctgg catttgctgt tttcattgaa atcaggttcg ttccatttga tagggagctg
     2041 ccagctctgt caaactgtga agatgaccca gcgtctcatc accttttcag tattacggga
     2101 aatgtgggcc atgtggtggg cggggaatgt atgtgcatgt tgttgtgagt atgtgatcat
     2161 agaagaaaga ctgaaacgga ggaagagata gaggatcagg ggttggggag ggagttaagg
     2221 gagaggagga agtggaagag gaagaggagg agggaggagg agaaaggggg aggaagaaaa
     2281 ggaggaagag gagaaaggag gaggaagaaa aggagaaaat gaggaagaga aggaaaagaa
     2341 gaaaagaagg gggaggaaga ggagaaggag gaagaggaag agaggaagag aagcaagctg
     2401 ctcaagccac cacagctgaa tttaggacat cttgggacca aagagcatga gtcaagatgt
     2461 ttgatgctgc cagggttgta agaaaggaca cagatttgtg gaggactggg agcagtagta
     2521 ttcagaacca aaaatatgtc tctttgtgaa aaggaaatca taactggaat tgtctgatat
     2581 ttaaaaaatt caggacctca gtattcaatg gaggctttgt ccttcacagg gggcagttga
     2641 gaggtgacct tggtggctac catggtcaga gaccacacag gcattgtggg taggtgggct
     2701 ccagttttcc ttaatgagtc gcgaacgctg tgcgttcgtc agaacgaagt ctacaagtca
     2761 atggtttttt tctttttata taataattat ataacttatg catttataca ctacgagttg
     2821 acctcggcca gccaaagaca ccacacacac acacacacac acacacacac acacacacac
     2881 acacacaaaa gagacaatca aacatatgat gtggccttga attttaactc tgtaatgctt
     2941 aatgtttaca atatgaagtt actagttctt agaatgcaga atgtatgtta ataaaaatga
     3001 gcttggcctc tcatggcgaa ccagaa
//
LOCUS       NM_001437793             645 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 20 open reading frame
            144 (C3h20orf144), transcript variant 3, mRNA.
ACCESSION   NM_001437793 XM_006235357
VERSION     NM_001437793.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006235357.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2786005.1,
                                           SRR26643293.19794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000003.1  163514345-163514523
            180-645             JAXUCZ010000003.1  163515018-163515483
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..645
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="similar to human chromosome 20 open reading frame
                     144"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
     exon            1..179
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..590
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="isoform 3 is encoded by transcript variant 3;
                     uncharacterized protein C20orf144 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C20orf144 homolog
                     isoform 3"
                     /protein_id="NP_001424722.1"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
                     /translation="MGNSGSHKRTKAPNQASKDRPPDMDKARHKQFFSHLKRKKPSTK
                     IVLLFPLDKRQQLAEAAAGPFVRPVRPAEDPLGAPTCFPATVAPMLRGAGDGVDRREG
                     ARAREMKRILVLLLQLDARLQEEGRRVAGRPGGGAKAQQYWQPLYAHLLTQREACGEG
                     DPREEQPRKRRRCPRPRP"
     misc_feature    54..563
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     misc_feature    54..563
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     exon            180..645
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggcagg gctgaggcag catgggcagt ggcttctagt gaccagtcct atcatgggaa
       61 acagcggttc ccacaagagg accaaagcac ccaatcaggc cagcaaggac aggccacctg
      121 acatggacaa ggcccgtcac aagcagttct tcagccacct caagcggaag aagccaagta
      181 ccaagatcgt gctgcttttc ccgctggaca agcggcagca gctggccgag gcagcggcgg
      241 gcccatttgt gcggcccgtg cggcccgctg aggacccgct cggcgccccg acgtgcttcc
      301 cagccacggt ggcgcctatg ctacgtgggg caggcgacgg cgtggacagg cgcgaaggtg
      361 cgcgcgcgag agagatgaaa aggatcctgg tgctgctgct gcagctggac gcgaggctgc
      421 aggaggaggg gcgtcgagtg gcaggcaggc cggggggcgg ggccaaggcc cagcagtact
      481 ggcagccgct gtatgcgcac ctgctgaccc aacgcgaggc ctgcggcgaa ggcgaccccc
      541 gcgaggagca gccgcgcaag cggcgccgct gtcctcgccc gcggccctga gtgtctggca
      601 cgacccctaa cgccaggact ctgctcaata aagagcacat agcaa
//
LOCUS       NM_001437769            1615 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 8, mRNA.
ACCESSION   NM_001437769 XM_063270524
VERSION     NM_001437769.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.66961.1,
                                           SRR26360194.1665223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000011.1  77465446-77465485   c
            41-110              JAXUCZ010000011.1  77464858-77464927   c
            111-222             JAXUCZ010000011.1  77462369-77462480   c
            223-385             JAXUCZ010000011.1  77461993-77462155   c
            386-515             JAXUCZ010000011.1  77456828-77456957   c
            516-609             JAXUCZ010000011.1  77452674-77452767   c
            610-709             JAXUCZ010000011.1  77449073-77449172   c
            710-888             JAXUCZ010000011.1  77444544-77444722   c
            889-998             JAXUCZ010000011.1  77442290-77442399   c
            999-1108            JAXUCZ010000011.1  77440692-77440801   c
            1109-1251           JAXUCZ010000011.1  77435682-77435824   c
            1252-1400           JAXUCZ010000011.1  77433449-77433597   c
            1401-1615           JAXUCZ010000011.1  77432471-77432685   c
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1615
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..40
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            41..110
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    81..83
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     exon            111..222
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1451
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 2 is encoded by transcript variant 8; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 2"
                     /protein_id="NP_001424698.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAASIKISSLGLERWLSG"
     misc_feature    990..>1070
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    990..>1070
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    <999..>1433
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <999..>1433
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1275..>1397
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <1275..>1397
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    1296..1352
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1296..1352
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            223..385
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            386..515
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..609
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            610..709
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            710..888
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            889..998
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1108
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1251
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1400
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1615
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag tgattcctgg aagcagtgaa
       61 gggcacggcc ttgggattct tgattcctca aaggtcagcc tagcaacagg gtggtagaaa
      121 aaatgaagcc agcgggtaca gacccaagga tcttgtcttt agctgctgaa gtagcgaaaa
      181 gtcctgaaca aaatgtccct gttatattat tgaagttaaa agaaataata aacaacaccc
      241 ctttgggaag ctcagagtta aagaaagtca agcaagatat atattgttat gacctcattc
      301 aatactgtct attggtcctc agtcaagatt cttctcgaat ccagggtggt tggtctacaa
      361 tttcccagct gacacagata ctaagccatt gctgtgtggg attagagcca ggagaagatg
      421 gagaagaatt ttacaaggaa ttacttccat cagctgccga aaattttctt gtcctgggaa
      481 gacgattgca aacatgtttt atcaatgcaa ctaagggtga agagcaagat aaattactac
      541 attttttcca aattgtgact gattctctct tctggctatt gggaggtcat attcaactca
      601 tacagaatgt actgcagagt gatcatttct tgcacctact gcaaactgac aatgttcaaa
      661 taggagctac agtcatgact ctgcttcaga atatactaca gatcaacagt ggtaatttac
      721 tcaaaataga aggaaaagcc ctgcattcta ttttagatga aattcttttc aagcttttgt
      781 caactcctag tccagtcata agaagtactg ctacaaagct cctactggta ttggctgaat
      841 cccatcagga aattttgatt ttactgagac taagtgcctg ctataaagga cttagaagtc
      901 tgctaaataa acaggaaact cttacagaat ttagtcgaga acttagacag ctcgttgatc
      961 ttttaacccc taagatccaa caggaagtag aagaacagaa actacataaa gcagcttgct
     1021 tgattcaagc ctattggaaa ggtttccaga ccagaaaaag attaaagaag cttccgtctg
     1081 ctgtgattgc cttgcagagg agtttcagag ctaaacgaac aaagatgttg ttggagctaa
     1141 ataggcagaa ggaagaagaa gacctcagat taagattgca acttcaaaaa cagagagcca
     1201 tgaggctttc ccgagagtca cgcttgagta tgcttgaaat aattcatcca ggtcaagtgg
     1261 agaaatacaa tagggaaata gaagagaaat ctgcattgac tatccagaaa cattggagag
     1321 ggtacaggga aaggaagaat tttcgccaac agaggccatc tctcacagag tataaagcag
     1381 ctgtcacact tcagagagca gcctctatta agatttcaag tctggggctg gagagatggc
     1441 tcagcggtta agagcactga ctgctcttcc agaggtcctg agttcaattc ccagcaacca
     1501 cgtggtggct cacaaccatc tgtaatggga tctgatgccc tcttctgctg tgtctgaaga
     1561 cagctacaat gtactcttat acatgaaata aataaagtaa atctttaaaa aaaaa
//
LOCUS       NM_001437700            4745 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 20,
            mRNA.
ACCESSION   NM_001437700 XM_063270239
VERSION     NM_001437700.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1889992.1,
                                           SRR26643290.40176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000011.1  98085846-98085923
            79-226              JAXUCZ010000011.1  98101064-98101211
            227-273             JAXUCZ010000011.1  98105694-98105740
            274-345             JAXUCZ010000011.1  98106090-98106161
            346-432             JAXUCZ010000011.1  98108322-98108408
            433-595             JAXUCZ010000011.1  98109928-98110090
            596-716             JAXUCZ010000011.1  98113029-98113149
            717-848             JAXUCZ010000011.1  98115531-98115662
            849-1055            JAXUCZ010000011.1  98117537-98117743
            1056-1176           JAXUCZ010000011.1  98123938-98124058
            1177-1332           JAXUCZ010000011.1  98124251-98124406
            1333-1422           JAXUCZ010000011.1  98124558-98124647
            1423-1515           JAXUCZ010000011.1  98126328-98126420
            1516-1572           JAXUCZ010000011.1  98128415-98128471
            1573-1767           JAXUCZ010000011.1  98131039-98131233
            1768-1877           JAXUCZ010000011.1  98131384-98131493
            1878-2037           JAXUCZ010000011.1  98133415-98133574
            2038-4745           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4745
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..78
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="upstream in-frame stop codon"
     exon            79..226
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..273
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..345
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..432
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2094
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 19 is encoded by transcript variant 20;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 19"
                     /protein_id="NP_001424629.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMAT
                     SEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLD
                     INNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRIN
                     VLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARIC
                     YIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLE
                     EPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV
                     HNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKVASAGGGIG
                     DGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPV
                     PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVG
                     QLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    1801..2073
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1801..2073
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            433..595
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..716
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..848
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1055
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1176
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1332
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1515
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1572
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1767
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1877
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2037
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..4745
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgtcgc ttccttccgg cggctgaggt ccggacgggc tctggagttg cggtggacag
       61 aagggcagca agctagtgag cagtggaaag agctcagtgc tggaaagcct agtggggagg
      121 gaccttcttc ccagagggac tggtgtggtc acccggagac ctcttattct gcagctggtc
      181 cacgtttcac cagaagataa aagaaaaaca acaggagaag aaaatggagt tgaagcagaa
      241 gaatggggta aatttcttca caccaaaaac aagctttaca cagattttga tgaaattcga
      301 caagaaattg aaaatgaaac tgaaagaatt tcaggaaata ataagggagt aagccctgag
      361 ccaatccatc tcaaggtttt ctcgcccaac gttgtcaacc tgacgcttgt ggatttacca
      421 ggaatgacca aagtacctgt aggtgatcag cccaaggata ttgagcttca aatcagagaa
      481 cttattcttc ggttcatcag taatcccaat tccattatcc ttgctgtcac tgctgcaaat
      541 acagatatgg caacgtcaga ggcacttaag atttccagag aggtagatcc agatgggcgc
      601 agaactctag ctgtaatcac caagcttgat ctcatggatg cgggtactga tgccatggat
      661 gtattgatgg gaagggttat tccagtcaag cttggaataa ttggagtagt taacaggagc
      721 caactggaca ttaacaataa gaagagtgta actgattcaa tccgtgatga gtatgctttt
      781 cttcaaaaga agtacccatc tctggccaac agaaatggaa caaagtatct tgctaggact
      841 ctgaataggt tacttatgca tcatatcaga gactgtttac cagagctgaa aacaagaata
      901 aatgtcttag ctgctcagta tcagtctctt ctaaatagct atggtgagcc cgtggatgat
      961 aaaagtgcta ctttactcca gctcattacc aagtttgcca cagagtattg taacactatt
     1021 gaaggaacgg caaagtacat tgaaacttct gagctatgtg gtggtgctag gatttgttat
     1081 attttccatg agacttttgg gcgaacctta gaatctgttg atccactagg tggccttaac
     1141 actattgaca tcttgaccgc cattagaaat gctactggcc cccgtccagc tttatttgtg
     1201 cctgaagttt catttgagtt actggtcaaa cgtcagatta agcgtctaga ggagcccagc
     1261 ctccgctgtg tggagctggt ccacgaggaa atgcagagga tcattcagca ctgtagcaac
     1321 tacagcacac aggaactgtt acggttccct aaactccatg atgccatagt tgaagtagtg
     1381 acttgtcttc ttcgtaaaag gttgcccgtg acaaatgaaa tggtacataa cttagtggca
     1441 attgagctag catatatcaa cacaaaacac cccgactttg ctgatgcctg tgggctaatg
     1501 aacaataaca tagaggaaca aagaagaaac agactagcaa gagaactacc ttccgctgta
     1561 tcgcgagaca aggttgcatc tgcaggtggt ggaattggag atggtggtcg aattggagat
     1621 ggtggtcagg aaccgacaac aggcaactgg agaggaatgc tgaaaacttc aaaagctgaa
     1681 gaattacttg ctgaagaaaa atcaaaacca attccaatta tgccagcaag tccacaaaaa
     1741 ggccatgctg tcaatttgct agatgtgcca gttccagttg cacgaaaact gtctgcccga
     1801 gaacagcgag attgtgaggt tattgaaaga ctcatcaaat catattttct aattgtcaga
     1861 aagaatattc aagacagcgt cccaaaggca gtaatgcatt ttttggttaa tcatgtgaaa
     1921 gatactcttc agagtgaatt agtagggcag ctgtataagt catccttatt agatgacctt
     1981 ctgactgaat ccgaggacat ggcacagcga agaaaagaag cggctgacat gctgaaggca
     2041 ttacaaggag ccagtcaaat tattgctgaa atccgagaga ctcatctttg gtgaacagaa
     2101 ctgtttggtc ttctacactt tgctgacttg aacctactag ctactgccta cctgagtaga
     2161 aatttattta tggacttttg tgtatcgcag tgtatgaatt tgcttgtgtg aagactggct
     2221 ataagctgaa aagtatatta ttcattacaa gacaaatcac atgtttaatt cacatttttc
     2281 aagtttccta tgatgtatat caagtctgtc cgtttcagtc aaacttacaa gaacaattga
     2341 tgttctagtt gtacaaagca gtttgcctgt gcatatgatg acctgcgtaa ccttttttta
     2401 gtcttaaagc tgcagccgta gtcctcaaag aggaagctcc aggacatttc atgactataa
     2461 tgcatgcact atttatatag actgacctgg cttcaaaagg tggagcctgg cgagttcctc
     2521 acataatcaa tgtatccacc tatccttcat ttttatagtc ttaaaaaaca aacaaaattc
     2581 tgaaacttct gcagttttag gaaaaatata agatctgaaa gactcataaa gatgtaggaa
     2641 cagactgtgt aattaatggc tcctgagtct atactgccct aatgttagaa agtaaaatat
     2701 gctttgattc aaaataagcc tgaaaatata aattgacttc ctgcattaaa aataactatt
     2761 aggaactttc ttagtaacaa taactggtcc tgttagtttc taaatgactc agtgacaacc
     2821 taaatttccc taatttacaa gtacatcgat tgcagtccag atgcacctta gggtggggcg
     2881 ctgactctgg gctccgagac tcagttatgt gagacctaaa agtctactct gtatccactg
     2941 gtaatgctac tttatagttc cacaccaaca gaatacattt gtcaaagaaa aatacctgga
     3001 catacacata cacctaaaag cttatggact actaaactgt attcaggggt tgaggattta
     3061 caacctattt tgtgaaaact gcctgtgcaa ttcaatttct gacctagctg ggcagtggtg
     3121 gtgcacacct ttaatcccag cttttgggag gcagaggcag gtggatctct gagttcaagg
     3181 ccagcctggt ctacagagtt gagttccaag acaaccagaa ctacacagag aaaccctgtc
     3241 ttgaaccccc ctccccccaa aaaattgaaa cctaaataga aatctttgat gtatctagtt
     3301 ttctctgacc aaatgataca tttgtgttat aaatactaaa attcttttca ggtcaggcat
     3361 cttatgaaat actattagca aggaaaacaa gaacatgtta tctttagttt agatgcccat
     3421 tgaaccatct caaaaacaaa ggcagtctga taacagtacc agcttgacag tgagtataca
     3481 ctgcctaaat gtgttagcat acttaagaaa aatatcctgt tatctaacta ttaggtatcc
     3541 atggtttatt ttttaagaga gatgaccacc actgtagcct tttgaatttg taaagagaaa
     3601 gaatgcacct ttatccaaca tttcaaatag attttaaaag gaagatgtta gctttaaaaa
     3661 cgtgctatga taatgtactt gttagcacta cacactttgt acaaagaaaa acaagcaaga
     3721 aaggtaggga aatgaaagct tcctttgtgt acttttacac taagctgtgt tctgaaacat
     3781 ggagataatt tataagacca ctgtatgttc tatgtaaata aaaatgctgg tgtgaaatgg
     3841 cattacggtt tgccagtaag tgaattcttc ctgacttgcc gtaagagaga ggtttaaata
     3901 ggtgcatctt tgaaatatct gaatctactt cataatggaa cgatttaaat tgtactgcac
     3961 caaaagtttt atgccatttt tttaattaga taatcaccac caaggccttg ttacatcttt
     4021 gtgtctacag atgaagacag aaacttcttc caagtaatcc aaggatgaat gctgagaaca
     4081 tgaactttgc tgcaagacgt ctagaagctg atccacagtt tatgtttcac ccctatgtac
     4141 attggggtgg tgctatcttg atttttacag aaactgtttt tgagaattag cttgccttgt
     4201 gtatacaaac ctgaactagt ttgacttcaa aacttcctgt atcttttctg ttcttactga
     4261 ctgcatactt gatgagatac tttttgtttc tttggtttct taaaatatct gctataggaa
     4321 cccactggca aaaataggca gttatcagta aattattgaa acacagaaca aggaagtgga
     4381 aaactgaact ataaatgaag tctggtactg attgatgttt tgttttaaga aaaaactatt
     4441 ttgtactaca gtttctattg ggaaccactg ccatatctaa ctccttttta agaattctgt
     4501 ttgcttggca gcatcaatca gaagtttaac tttgtaacag atttctcaca tctaaacaga
     4561 cattagaagc ttggccagtt tgtacagcta tgtaacacaa ctgcaatcag gtgcttacct
     4621 tacctcctgt gttaacttta tacagtcatt tccactgcac cacttcttca gaccaaggag
     4681 caagaaagat cattcttgca taaagaaatg aactataatt aaatatcact ttattttgaa
     4741 atgca
//
LOCUS       NM_001437688            4999 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 8,
            mRNA.
ACCESSION   NM_001437688 XM_063270234
VERSION     NM_001437688.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4999)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4999)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4999)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4999)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4999)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4999)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4999)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4999)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4999)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270234.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.816473.1,
                                           SRR26360190.161875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-449             JAXUCZ010000011.1  98105694-98105740
            450-521             JAXUCZ010000011.1  98106090-98106161
            522-608             JAXUCZ010000011.1  98108322-98108408
            609-771             JAXUCZ010000011.1  98109928-98110090
            772-892             JAXUCZ010000011.1  98113029-98113149
            893-1024            JAXUCZ010000011.1  98115531-98115662
            1025-1231           JAXUCZ010000011.1  98117537-98117743
            1232-1352           JAXUCZ010000011.1  98123938-98124058
            1353-1508           JAXUCZ010000011.1  98124251-98124406
            1509-1598           JAXUCZ010000011.1  98124558-98124647
            1599-1691           JAXUCZ010000011.1  98126328-98126420
            1692-1748           JAXUCZ010000011.1  98128415-98128471
            1749-1826           JAXUCZ010000011.1  98129086-98129163
            1827-2021           JAXUCZ010000011.1  98131039-98131233
            2022-2131           JAXUCZ010000011.1  98131384-98131493
            2132-2291           JAXUCZ010000011.1  98133415-98133574
            2292-4999           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4999
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2348
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 8 is encoded by transcript variant 8;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 8"
                     /protein_id="NP_001424617.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWRVEAEEWGKFLHT
                     KNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVP
                     VGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLA
                     VITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQ
                     KKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDD
                     KSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGG
                     LNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQ
                     HCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFA
                     DACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKVA
                     SAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAV
                     NLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDT
                     LQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2055..2327
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2055..2327
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..449
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..521
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..608
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..892
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1024
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1231
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1352
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1508
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1598
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1691
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1748
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1826
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2021
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2131
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2291
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..4999
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gagagttgaa gcagaagaat
      421 ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa attcgacaag
      481 aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc cctgagccaa
      541 tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat ttaccaggaa
      601 tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc agagaactta
      661 ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct gcaaatacag
      721 atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat gggcgcagaa
      781 ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc atggatgtat
      841 tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac aggagccaac
      901 tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat gcttttcttc
      961 aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct aggactctga
     1021 ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca agaataaatg
     1081 tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg gatgataaaa
     1141 gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac actattgaag
     1201 gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt tgttatattt
     1261 tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc cttaacacta
     1321 ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta tttgtgcctg
     1381 aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag cccagcctcc
     1441 gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt agcaactaca
     1501 gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa gtagtgactt
     1561 gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta gtggcaattg
     1621 agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg ctaatgaaca
     1681 ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc gctgtatcgc
     1741 gagacaagtc ttctaaagtt ccaagtgctt tggcacctgc ctcccaggag ccctcccctg
     1801 ccgcttctgc cgaggctgat ggcaaggttg catctgcagg tggtggaatt ggagatggtg
     1861 gtcgaattgg agatggtggt caggaaccga caacaggcaa ctggagagga atgctgaaaa
     1921 cttcaaaagc tgaagaatta cttgctgaag aaaaatcaaa accaattcca attatgccag
     1981 caagtccaca aaaaggccat gctgtcaatt tgctagatgt gccagttcca gttgcacgaa
     2041 aactgtctgc ccgagaacag cgagattgtg aggttattga aagactcatc aaatcatatt
     2101 ttctaattgt cagaaagaat attcaagaca gcgtcccaaa ggcagtaatg cattttttgg
     2161 ttaatcatgt gaaagatact cttcagagtg aattagtagg gcagctgtat aagtcatcct
     2221 tattagatga ccttctgact gaatccgagg acatggcaca gcgaagaaaa gaagcggctg
     2281 acatgctgaa ggcattacaa ggagccagtc aaattattgc tgaaatccga gagactcatc
     2341 tttggtgaac agaactgttt ggtcttctac actttgctga cttgaaccta ctagctactg
     2401 cctacctgag tagaaattta tttatggact tttgtgtatc gcagtgtatg aatttgcttg
     2461 tgtgaagact ggctataagc tgaaaagtat attattcatt acaagacaaa tcacatgttt
     2521 aattcacatt tttcaagttt cctatgatgt atatcaagtc tgtccgtttc agtcaaactt
     2581 acaagaacaa ttgatgttct agttgtacaa agcagtttgc ctgtgcatat gatgacctgc
     2641 gtaacctttt tttagtctta aagctgcagc cgtagtcctc aaagaggaag ctccaggaca
     2701 tttcatgact ataatgcatg cactatttat atagactgac ctggcttcaa aaggtggagc
     2761 ctggcgagtt cctcacataa tcaatgtatc cacctatcct tcatttttat agtcttaaaa
     2821 aacaaacaaa attctgaaac ttctgcagtt ttaggaaaaa tataagatct gaaagactca
     2881 taaagatgta ggaacagact gtgtaattaa tggctcctga gtctatactg ccctaatgtt
     2941 agaaagtaaa atatgctttg attcaaaata agcctgaaaa tataaattga cttcctgcat
     3001 taaaaataac tattaggaac tttcttagta acaataactg gtcctgttag tttctaaatg
     3061 actcagtgac aacctaaatt tccctaattt acaagtacat cgattgcagt ccagatgcac
     3121 cttagggtgg ggcgctgact ctgggctccg agactcagtt atgtgagacc taaaagtcta
     3181 ctctgtatcc actggtaatg ctactttata gttccacacc aacagaatac atttgtcaaa
     3241 gaaaaatacc tggacataca catacaccta aaagcttatg gactactaaa ctgtattcag
     3301 gggttgagga tttacaacct attttgtgaa aactgcctgt gcaattcaat ttctgaccta
     3361 gctgggcagt ggtggtgcac acctttaatc ccagcttttg ggaggcagag gcaggtggat
     3421 ctctgagttc aaggccagcc tggtctacag agttgagttc caagacaacc agaactacac
     3481 agagaaaccc tgtcttgaac ccccctcccc ccaaaaaatt gaaacctaaa tagaaatctt
     3541 tgatgtatct agttttctct gaccaaatga tacatttgtg ttataaatac taaaattctt
     3601 ttcaggtcag gcatcttatg aaatactatt agcaaggaaa acaagaacat gttatcttta
     3661 gtttagatgc ccattgaacc atctcaaaaa caaaggcagt ctgataacag taccagcttg
     3721 acagtgagta tacactgcct aaatgtgtta gcatacttaa gaaaaatatc ctgttatcta
     3781 actattaggt atccatggtt tattttttaa gagagatgac caccactgta gccttttgaa
     3841 tttgtaaaga gaaagaatgc acctttatcc aacatttcaa atagatttta aaaggaagat
     3901 gttagcttta aaaacgtgct atgataatgt acttgttagc actacacact ttgtacaaag
     3961 aaaaacaagc aagaaaggta gggaaatgaa agcttccttt gtgtactttt acactaagct
     4021 gtgttctgaa acatggagat aatttataag accactgtat gttctatgta aataaaaatg
     4081 ctggtgtgaa atggcattac ggtttgccag taagtgaatt cttcctgact tgccgtaaga
     4141 gagaggttta aataggtgca tctttgaaat atctgaatct acttcataat ggaacgattt
     4201 aaattgtact gcaccaaaag ttttatgcca tttttttaat tagataatca ccaccaaggc
     4261 cttgttacat ctttgtgtct acagatgaag acagaaactt cttccaagta atccaaggat
     4321 gaatgctgag aacatgaact ttgctgcaag acgtctagaa gctgatccac agtttatgtt
     4381 tcacccctat gtacattggg gtggtgctat cttgattttt acagaaactg tttttgagaa
     4441 ttagcttgcc ttgtgtatac aaacctgaac tagtttgact tcaaaacttc ctgtatcttt
     4501 tctgttctta ctgactgcat acttgatgag atactttttg tttctttggt ttcttaaaat
     4561 atctgctata ggaacccact ggcaaaaata ggcagttatc agtaaattat tgaaacacag
     4621 aacaaggaag tggaaaactg aactataaat gaagtctggt actgattgat gttttgtttt
     4681 aagaaaaaac tattttgtac tacagtttct attgggaacc actgccatat ctaactcctt
     4741 tttaagaatt ctgtttgctt ggcagcatca atcagaagtt taactttgta acagatttct
     4801 cacatctaaa cagacattag aagcttggcc agtttgtaca gctatgtaac acaactgcaa
     4861 tcaggtgctt accttacctc ctgtgttaac tttatacagt catttccact gcaccacttc
     4921 ttcagaccaa ggagcaagaa agatcattct tgcataaaga aatgaactat aattaaatat
     4981 cactttattt tgaaatgca
//
LOCUS       NM_001437765            2253 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 4, mRNA.
ACCESSION   NM_001437765 XM_008768730
VERSION     NM_001437765.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2253)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2253)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2253)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2253)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2253)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2253)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2253)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2253)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2253)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2253)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_008768730.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.48203.1,
                                           SRR26360172.999044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000011.1  77465446-77465485   c
            41-110              JAXUCZ010000011.1  77464858-77464927   c
            111-227             JAXUCZ010000011.1  77462369-77462485   c
            228-390             JAXUCZ010000011.1  77461993-77462155   c
            391-520             JAXUCZ010000011.1  77456828-77456957   c
            521-614             JAXUCZ010000011.1  77452674-77452767   c
            615-714             JAXUCZ010000011.1  77449073-77449172   c
            715-893             JAXUCZ010000011.1  77444544-77444722   c
            894-1003            JAXUCZ010000011.1  77442290-77442399   c
            1004-1113           JAXUCZ010000011.1  77440692-77440801   c
            1114-1256           JAXUCZ010000011.1  77435682-77435824   c
            1257-1405           JAXUCZ010000011.1  77433449-77433597   c
            1406-1537           JAXUCZ010000011.1  77424393-77424524   c
            1538-1694           JAXUCZ010000011.1  77412154-77412310   c
            1695-2253           JAXUCZ010000011.1  77410986-77411544   c
FEATURES             Location/Qualifiers
     source          1..2253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2253
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..40
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            41..110
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            111..227
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     CDS             128..1924
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 1 is encoded by transcript variant 4; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 1"
                     /protein_id="NP_001424694.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWK
                     KLGEEPGDEMDVPKDELSIDLGTLFIGGTKPP"
     misc_feature    842..>1417
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    842..>1417
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    842..901
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    842..901
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    944..973
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    944..973
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    995..>1075
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    995..>1075
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1007..1069
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1007..1069
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1094..1234
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1094..1234
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1301..1357
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1301..1357
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            228..390
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            391..520
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..614
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            615..714
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            715..893
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1003
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1113
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1256
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1405
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1537
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1694
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..2253
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag tgattcctgg aagcagtgaa
       61 gggcacggcc ttgggattct tgattcctca aaggtcagcc tagcaacagg cataggtggt
      121 agaaaaaatg aagccagcgg gtacagaccc aaggatcttg tctttagctg ctgaagtagc
      181 gaaaagtcct gaacaaaatg tccctgttat attattgaag ttaaaagaaa taataaacaa
      241 cacccctttg ggaagctcag agttaaagaa agtcaagcaa gatatatatt gttatgacct
      301 cattcaatac tgtctattgg tcctcagtca agattcttct cgaatccagg gtggttggtc
      361 tacaatttcc cagctgacac agatactaag ccattgctgt gtgggattag agccaggaga
      421 agatggagaa gaattttaca aggaattact tccatcagct gccgaaaatt ttcttgtcct
      481 gggaagacga ttgcaaacat gttttatcaa tgcaactaag ggtgaagagc aagataaatt
      541 actacatttt ttccaaattg tgactgattc tctcttctgg ctattgggag gtcatattca
      601 actcatacag aatgtactgc agagtgatca tttcttgcac ctactgcaaa ctgacaatgt
      661 tcaaatagga gctacagtca tgactctgct tcagaatata ctacagatca acagtggtaa
      721 tttactcaaa atagaaggaa aagccctgca ttctatttta gatgaaattc ttttcaagct
      781 tttgtcaact cctagtccag tcataagaag tactgctaca aagctcctac tggtattggc
      841 tgaatcccat caggaaattt tgattttact gagactaagt gcctgctata aaggacttag
      901 aagtctgcta aataaacagg aaactcttac agaatttagt cgagaactta gacagctcgt
      961 tgatctttta acccctaaga tccaacagga agtagaagaa cagaaactac ataaagcagc
     1021 ttgcttgatt caagcctatt ggaaaggttt ccagaccaga aaaagattaa agaagcttcc
     1081 gtctgctgtg attgccttgc agaggagttt cagagctaaa cgaacaaaga tgttgttgga
     1141 gctaaatagg cagaaggaag aagaagacct cagattaaga ttgcaacttc aaaaacagag
     1201 agccatgagg ctttcccgag agtcacgctt gagtatgctt gaaataattc atccaggtca
     1261 agtggagaaa tacaataggg aaatagaaga gaaatctgca ttgactatcc agaaacattg
     1321 gagagggtac agggaaagga agaattttcg ccaacagagg ccatctctca cagagtataa
     1381 agcagctgtc acacttcaga gagcagttct taaattccta gcaaagtgcc gtaagaaaaa
     1441 gaaactcttt gcctcttggc atggactcca agaactcact gatgcacgcc gagttgaact
     1501 gaagcaacaa gtggatgact atgtcaaaag acatccgggc tctcagatgt cagatgtggc
     1561 cagcagagag ctccacgcac aagcacaaga acgacttcaa cactatttta tgggaagagc
     1621 catagaagag cgagcccagc aacacaggga agcattgatg gctcagatca gcaccaatat
     1681 tgagcagttg atgaaggcac caagtctgaa ggaggcggaa ggaaaggagc ctgagcagtt
     1741 cctgagtaga tctaggcctg tggcagccaa agccaagcag gcccacctta ccaccctgaa
     1801 gcacatacag gccccctggt ggaagaagct cggagaggaa ccaggggatg agatggatgt
     1861 tccaaaggac gagcttagta tagatttagg gactttattt attggtggaa ccaagcctcc
     1921 ctagagagtt actgggaaag ccggcattct taccttttaa gagattgttg gttttgcctc
     1981 tggcatgcag gaagactagg tctatgccag tggctttcca gagcatcttc ttcatgaaca
     2041 cttggaagca aagagcagag cattgcctac ctcactctca gttctttccc catctctaca
     2101 ccctgtctgt agtcacaaac agatttgtgg gcttttaatt gtgggacaga actcaatgtg
     2161 aaattttatt gttaatttga aatttctttc attctgtttt ctgactaaaa gttgttttgt
     2221 ttttgttttt aaataaatat tgtttctgaa aaa
//
LOCUS       NM_001437789            4106 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus paired box 2 (Pax2), transcript variant 1, mRNA.
ACCESSION   NM_001437789 XM_039109033
VERSION     NM_001437789.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Wang,X.L., Hou,L., Zhao,C.G., Tang,Y., Zhang,B., Zhao,J.Y. and
            Wu,Y.B.
  TITLE     Screening of genes involved in epithelial-mesenchymal transition
            and differential expression of complement-related genes induced by
            PAX2 in renal tubules
  JOURNAL   Nephrology (Carlton) 24 (2), 263-271 (2019)
   PUBMED   29280536
  REMARK    GeneRIF: Pax2 overexpression by kidney tubule cells alters the
            expression of complement system proteins to induce
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Hou,L., Du,Y., Zhao,C. and Wu,Y.
  TITLE     PAX2 may induce ADAM10 expression in renal tubular epithelial cells
            and contribute to epithelial-to-mesenchymal transition
  JOURNAL   Int Urol Nephrol 50 (9), 1729-1741 (2018)
   PUBMED   30117015
  REMARK    GeneRIF: PAX2 directly increased expression of ADAM10, the presence
            of which contributed to EMT in renal tubular epithelia and hence
            plays an important role in renal fibrosis.
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Larsson,M.
  TITLE     Pax2 is persistently expressed by GABAergic neurons throughout the
            adult rat dorsal horn
  JOURNAL   Neurosci Lett 638, 96-101 (2017)
   PUBMED   27939388
  REMARK    GeneRIF: Persistent Pax2 expression may be required to maintain a
            GABAergic phenotype.
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Jiang,Y., Jiang,T., Ouyang,J., Zhou,Q., Liang,Y., Cui,Y., Chen,P.
            and Huang,B.
  TITLE     Cell atavistic transition: Paired box 2 re-expression occurs in
            mature tubular epithelial cells during acute kidney injury and is
            regulated by Angiotensin II
  JOURNAL   PLoS One 9 (4), e93563 (2014)
   PUBMED   24710423
  REMARK    GeneRIF: Those findings suggest that mature TECs can
            trans-differentiate into progenitor-like cells by 'atavistic
            transition', which may participate in the recovery of tissue
            structure and Pax2 may play a pivotal role in this process.
            Erratum:[PLoS One. 2015 May 06;10(5):e0127718. doi:
            10.1371/journal.pone.0127718. PMID: 25945929]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Ryan,G., Steele-Perkins,V., Morris,J.F., Rauscher,F.J. 3rd and
            Dressler,G.R.
  TITLE     Repression of Pax-2 by WT1 during normal kidney development
  JOURNAL   Development 121 (3), 867-875 (1995)
   PUBMED   7720589
REFERENCE   7  (bases 1 to 4106)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   8  (bases 1 to 4106)
  AUTHORS   Sharma,P.M., Bowman,M., Yu,B.F. and Sukumar,S.
  TITLE     A rodent model for Wilms tumors: embryonal kidney neoplasms induced
            by N-nitroso-N'-methylurea
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9931-9935 (1994)
   PUBMED   7937920
REFERENCE   9  (bases 1 to 4106)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   10 (bases 1 to 4106)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039109033.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.3976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-734               JAXUCZ010000001.1  253565263-253565996
            735-900             JAXUCZ010000001.1  253569474-253569639
            901-1098            JAXUCZ010000001.1  253570262-253570459
            1099-1184           JAXUCZ010000001.1  253597330-253597415
            1185-1304           JAXUCZ010000001.1  253599070-253599189
            1305-1480           JAXUCZ010000001.1  253624514-253624689
            1481-1607           JAXUCZ010000001.1  253626927-253627053
            1608-1709           JAXUCZ010000001.1  253641498-253641599
            1710-1796           JAXUCZ010000001.1  253643737-253643823
            1797-4106           JAXUCZ010000001.1  253644316-253646625
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4106
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
     exon            1..734
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    338..340
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="upstream in-frame stop codon"
     CDS             692..1918
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paired box protein Pax-2; paired box gene 2; paired box
                     protein 2; paired box homeotic gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2 isoform 1"
                     /protein_id="NP_001424718.1"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
                     /translation="MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELA
                     HQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYK
                     RQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAP
                     GHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKREEDVSEGSVPNGDSQS
                     GVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGL
                     DEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTL
                     AGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLMPPPGAPPLPLLPLPMTATSYRGD
                     HIKLQADSFGLHIVPV"
     misc_feature    734..1108
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    734..1108
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    order(749..754,767..769,773..781,785..787,800..802,
                     836..838,842..844,869..871,878..880,884..889,899..901,
                     926..946,950..961,1016..1024,1079..1081,1085..1090,
                     1097..1099,1106..1108)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    order(749..754,767..769,773..781,785..787,800..802,
                     836..838,842..844,869..871,878..880,884..889,899..901,
                     926..946,950..961,1016..1024,1079..1081,1085..1090,
                     1097..1099,1106..1108)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    1532..>1789
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     misc_feature    1532..>1789
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     exon            735..900
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1098
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1184
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1304
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1480
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1607
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1709
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1796
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..4106
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccagtct ccggccgagt cttcttgcag ccgcaaccca cctggggcca gcccagcgct
       61 gcgggcgccg ctcggctcct aggctgcctc cctccctctt ggcccttcgg ccgccgcggc
      121 gtgcgcctgc cttttccggg ggcgggggcc ggctcgcacg ctcccctccc gcgggcgccc
      181 gcttggacat cccggggatt gctacttctc tgccaacttc gccaactcgc cggcacttgg
      241 agcggcccgg ctcccctcct ggcgccctcg ggccgccccc gccctgagct ctcttggttc
      301 agagcctctc ggacgacggg gttccagggg agctgagtga gctgtcttcc ctacccggcc
      361 tcagctctgg ccgcagctgg cgcgcgagcc atgcgccccc agtgcccctt ggtccagccg
      421 gtcgcccggg ggctgctttg ctgactgccc agccgcgtgc cccaacggtg gcaagttgca
      481 gtcgctgcgg ttgcaaaccc cagcgggccc ggaggagtcc cggcgtggag cgcagcgcgg
      541 tgccccccgc cctcgcttgc cccccagcag ccgggcgccc gctcactctc cctcccccac
      601 cgtcccttcc ttttctcctc aagtcctgaa gttgagtttg agaggcgaca cggcggcggc
      661 ggccgcgctg ctcccgctcc tctgcctccc catggatatg cactgcaaag cagacccctt
      721 ctccgcgatg caccggcacg ggggtgtgaa ccagctcggg ggggtgtttg tgaacggccg
      781 gcccctaccc gacgtggtga ggcagcgcat cgtggagctg gcccaccagg gtgtgcggcc
      841 ctgtgacatc tcccggcagc tgcgggtcag ccatggctgt gtcagcaaaa tcctgggcag
      901 gtactacgag actggcagca tcaagcccgg agtgattggt ggctccaagc ccaaggtggc
      961 aacgcccaaa gtggtggaca agattgctga atacaagcga cagaacccga ctatgttcgc
     1021 ctgggagatc cgggacaggc tgctagctga gggcatctgc gacaatgata cagttcccag
     1081 cgtctcatcc atcaacagga tcatccggac caaagttcag cagcctttcc acccaacgcc
     1141 ggatggggca gggacaggag tgactgcccc tggccacacc atcgttccca gcacggcctc
     1201 ccctcctgtt tccagcgcct ctaacgaccc agtgggatcc tactccatca acgggatcct
     1261 ggggattcct cgctccaacg gtgagaagag gaaacgagag gaagatgtgt ccgagggctc
     1321 tgtccctaat ggagactccc agagtggtgt ggacagtttg cggaagcacc tgcgagccga
     1381 caccttcacc cagcagcagc tggaagcttt ggatcgagtc tttgagcgtc cttcctatcc
     1441 cgatgtcttc caagcatcag agcacatcaa atcagaacag gggaatgaat actctctccc
     1501 agccctgacc cctgggcttg atgaagtcaa gtccagtcta tctgcatcta ccaaccctga
     1561 gctgggcagc aatgtgtcag gcacacagac gtaccccgtc gtgaccggtc gtgatatggc
     1621 gagcaccact ctacctggtt acccccctca tgtgcccccc actggccagg gaagctaccc
     1681 tacctccacc ctggcaggaa tggtgcctgg gagcgagttc tcaggcaacc catacagcca
     1741 tccccagtac accgcctaca atgaggcttg gagattcagc aaccccgcct tactaatgcc
     1801 gccccccggg gctccgcccc tgccgctgct gccgctgcct atgaccgcca ctagttaccg
     1861 cggggaccac atcaagcttc aggcagacag cttcggcctc cacatcgtcc ccgtctgacc
     1921 gcccacccca gagggaggga ggaccgaagc gacgcgctgc ctctcggcca ccgtccctgt
     1981 cccaccccca cctcgagaca tcccacgccc ccgaagccct tcacgtcacc ctatcaaggc
     2041 cagacaggac aggtggagcc cagggtggga ccctcaggcc ccagccccgc ccgtcgcccc
     2101 tccccgcctg cctggaccgc ggcgccgccc ggaagccctc cggccgctgg cccgggcgcc
     2161 ggacacgttt ctgtgacaca caatcagcgt agcccacccg gggacagccc actttggacg
     2221 cccgggagcc gggaggcttc gctggaggag ctgagcaagg gaagctaagg aaaggacttt
     2281 gtgctgaagg aggagcggct ggcgaggggg ggaaatcctg ccccactccc cgagcctgcc
     2341 aggctgaatc cgccttatgt ctgcgcccgg ccccaggcag tggcactggg acgaaagggt
     2401 cggactcgag ggacagcttt tggggcgaca gcgttttccg aggctgggaa ccaaggctag
     2461 cagacgccaa ctgagctcat ccacctgaac tgcctcgttc cccagggcct gggatctcct
     2521 gctgcagtgg ctcgactctc ggccccgcct cgcccctacg tcagcgcctc ttccacctgc
     2581 tggcctctca cttttccctc ctgcgcttcc ttggctcatc ccacgacacc ttgtgtttgg
     2641 tcctaagcac gcagtcacgt cggggccacc gcgggaaccg tgtcctcagg ctgcggctgt
     2701 gagcattgat ctttcccatc agtaatgtgc tgcccccaca cccccgaccg gccccaaacc
     2761 cccaacctgc gggcgcaaag aacttggagg gaactgacga ccgaactgcc ccgaggtgaa
     2821 aacccgggac tgcccgcccc attcccctca acaacccccc tccccggacc ccccaagcct
     2881 tcccttgggc agatgctgaa cagagccgga aaaaaaaagt ctacacttat ttaatatgac
     2941 agtctttgca aaaacgaaca aaacagaaac ccaacaggct gctttgtaga aagacggtgt
     3001 gtgctgtgaa ggcgaacctc tctgtgtaca tatcccctcc ctctctgccc cgccccgccg
     3061 ggtaccgtag agtccctgtc ctccccacca ccctgcctgt agatacaccc ttctgtccgt
     3121 gctgtgagag tcgccgctcg ctggggggga ggggggacac agctacatgc ccactaaagc
     3181 acagcacgtc ctgggggagg ggggcatttt tttacgttac aaaaacaaat tatgaaagaa
     3241 atctctatgc aaaatgacga acatggtccc gcggacacct ctcgcctgtt tcgttggctg
     3301 tttctctgta attccgtgtt ttcgcgctca ccgccccgca tctctccctc ttcatctccc
     3361 ttttctctgc tgctctcggc ccttctgtgt ctctttctct gcttcacttg tctctgtctc
     3421 ggtcccttct gtcccaggcc tccaaggcta catcaaaggt ggcagagcca atctcggggc
     3481 ttggcccctt gtggccatgc cccacgtgcc ccaccaggcc gccctgcccc gccccaccct
     3541 gtagttgctc tctcggtagc ggcgatgctc cctgcatgtc tcctcaaccg tggatcgtga
     3601 cgactcgaaa taacagaaac aaagtaaata aaagtgaaaa aaaaacaagt aaataaataa
     3661 ataaataaat aaataaataa ataaataaat aaaaatcctt gaacaaatct gaaaaggctt
     3721 ggagtcctag cccagattgc gcttcccttc gagccttttt ctttgaaaag gaaagcgaga
     3781 aaagagaaca gtctaaggga actgccggca cccgaccggg ctccagtggc tggagccgga
     3841 tggtgagggc aatgaggtct cggcttcgag gcccagcctg accccagtct tgtgtggagc
     3901 tggccgcgct ccaggagtgc ggaatccagg ataaggctta gccttccaca agttcctggc
     3961 tcctctgcca ctttcaacgt gtcggttcgt tttgtttatt ttttcctttt tccccccttc
     4021 ctttccttct ctctcttctt tttttatgca catgataaat aataataata aataataata
     4081 ataataaaat tttgtatgtc actccc
//
LOCUS       NM_024129               1648 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus decorin (Dcn), transcript variant 2, mRNA.
ACCESSION   NM_024129 XM_343201
VERSION     NM_024129.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Hassan,G.M. and Ebrahim,R.H.
  TITLE     The myokine decorin improves the cardiac function in a rat model of
            isoprenaline-induced myocardial infarction
  JOURNAL   Can J Physiol Pharmacol 101 (6), 286-293 (2023)
   PUBMED   36917819
  REMARK    GeneRIF: The myokine decorin improves the cardiac function in a rat
            model of isoprenaline-induced myocardial infarction.
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Gaspar,R., Gomori,K., Kiss,B., Szantai,A., Paloczi,J., Varga,Z.V.,
            Pipis,J., Varadi,B., Agg,B., Csont,T., Ferdinandy,P., Bartekova,M.
            and Gorbe,A.
  TITLE     Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury
  JOURNAL   Molecules 25 (15), 3426 (2020)
   PUBMED   32731559
  REMARK    GeneRIF: Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1648)
  AUTHORS   Lai,J., Chen,F., Chen,J., Ruan,G., He,M., Chen,C., Tang,J. and
            Wang,D.W.
  TITLE     Overexpression of decorin promoted angiogenesis in diabetic
            cardiomyopathy via IGF1R-AKT-VEGF signaling
  JOURNAL   Sci Rep 7, 44473 (2017)
   PUBMED   28290552
  REMARK    GeneRIF: overexpression of decorin ameliorated diabetic
            cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF
            signaling pathway in vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1648)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 1648)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 1648)
  AUTHORS   De Cosmo,S., Tassi,V., Thomas,S., Piras,G.P., Trevisan,R., Cavallo
            Perin,P., Bacci,S., Zucaro,L., Cisternino,C., Trischitta,V. and
            Viberti,G.C.
  TITLE     The Decorin gene 179 allelic variant is associated with a slower
            progression of renal disease in patients with type 1 diabetes
  JOURNAL   Nephron 92 (1), 72-76 (2002)
   PUBMED   12187087
REFERENCE   7  (bases 1 to 1648)
  AUTHORS   Schaefer,L., Raslik,I., Grone,H.J., Schonherr,E., Macakova,K.,
            Ugorcakova,J., Budny,S., Schaefer,R.M. and Kresse,H.
  TITLE     Small proteoglycans in human diabetic nephropathy: discrepancy
            between glomerular expression and protein accumulation of decorin,
            biglycan, lumican, and fibromodulin
  JOURNAL   FASEB J 15 (3), 559-561 (2001)
   PUBMED   11259366
REFERENCE   8  (bases 1 to 1648)
  AUTHORS   Asundi,V.K. and Dreher,K.L.
  TITLE     Molecular characterization of vascular smooth muscle decorin:
            deduced core protein structure and regulation of gene expression
  JOURNAL   Eur J Cell Biol 59 (2), 314-321 (1992)
   PUBMED   1493796
REFERENCE   9  (bases 1 to 1648)
  AUTHORS   Abramson,S.R. and Woessner,J.F. Jr.
  TITLE     cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin)
  JOURNAL   Biochim Biophys Acta 1132 (2), 225-227 (1992)
   PUBMED   1390895
REFERENCE   10 (bases 1 to 1648)
  AUTHORS   Kokenyesi,R. and Woessner,J.F. Jr.
  TITLE     Purification and characterization of a small dermatan sulphate
            proteoglycan implicated in the dilatation of the rat uterine cervix
  JOURNAL   Biochem J 260 (2), 413-419 (1989)
   PUBMED   2764879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 9, 2025 this sequence version replaced NM_024129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083750.1, FQ228702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000007.1  34167943-34167998
            57-276              JAXUCZ010000007.1  34171780-34171999
            277-389             JAXUCZ010000007.1  34183041-34183153
            390-603             JAXUCZ010000007.1  34194575-34194788
            604-717             JAXUCZ010000007.1  34195743-34195856
            718-811             JAXUCZ010000007.1  34200078-34200171
            812-950             JAXUCZ010000007.1  34203914-34204052
            951-1648            JAXUCZ010000007.1  34207307-34208004
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1648
                     /gene="Dcn"
                     /note="decorin"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
     exon            1..56
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    51..53
                     /gene="Dcn"
                     /note="upstream in-frame stop codon"
     exon            57..276
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1145
                     /gene="Dcn"
                     /note="dermatan sulfate proteoglycan-II (decorin); DSPG;
                     PG40; PG-S2; bone proteoglycan II"
                     /codon_start=1
                     /product="decorin precursor"
                     /protein_id="NP_077043.1"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
                     /translation="MKATLVLFLLAQVSWAGPFEQRGLFDFMLEDEASGIIPYDPDNP
                     LISMCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKDL
                     HTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKL
                     KKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLPTSI
                     SELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKL
                     LRVPAGLAQHKYVQVVYLHNNNISEVGQHDFCLPSYQTRKTSYTAVSLYSNPVRYWQI
                     HPHTFRCVFGRSTIQLGNYK"
     sig_peptide     81..128
                     /gene="Dcn"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     171..1142
                     /gene="Dcn"
                     /product="Decorin. /id=PRO_0000032720"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1)"
     misc_feature    180..182
                     /gene="Dcn"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000269|PubMed:2764879; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    222..320
                     /gene="Dcn"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    222..320
                     /gene="Dcn"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    249..311
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    249..311
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    282..344
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 1"
     misc_feature    312..>986
                     /gene="Dcn"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    312..>986
                     /gene="Dcn"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    312..383
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    312..383
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    345..416
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 2"
     misc_feature    384..455
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    384..455
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    417..488
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 3"
     misc_feature    456..518
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    456..518
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    489..551
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 4"
     misc_feature    519..590
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    519..590
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    552..623
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 5"
     misc_feature    591..668
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    591..668
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    624..701
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 6"
     misc_feature    669..731
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    669..731
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    696..698
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    702..764
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 7"
     misc_feature    732..803
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    732..803
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    765..836
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 8"
     misc_feature    801..803
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    804..875
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    804..875
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    837..908
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 9"
     misc_feature    849..851
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    909..977
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 10"
     misc_feature    945..1004
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    945..1004
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    972..974
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    978..1067
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 11"
     misc_feature    1014..1097
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1014..1097
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1068..1142
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 12"
     exon            277..389
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            390..603
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            604..717
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            718..811
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            812..950
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1648
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttaatt acatcgcagc tttgagggct ccggtggcaa atacccggat taaaaggtgg
       61 tgaaaacgca tgagacaacc atgaaggcaa ctctcgtctt attccttctg gcgcaagtct
      121 cttgggctgg accatttgag cagagaggat tatttgactt catgctagaa gatgaggcct
      181 ctggcataat cccttacgac cctgacaatc ccctgatatc tatgtgcccc taccgatgcc
      241 aatgccatct ccgagtggtg cagtgttctg atctgggtct ggacaaagta ccctgggaat
      301 ttccacctga cacaacattg ctagacctgc aaaacaacaa aataacagag atcaaagagg
      361 gggcctttaa gaacctgaag gacttgcata ccttgatcct tgtcaacaac aagatcagca
      421 agatcagccc agaggcattt aaacctctag tgaagttgga aaggctttat ctgtctaaga
      481 accacctaaa ggagctgccc gaaaaattgc ccaaaacact ccaggagctt cgactccacg
      541 acaatgagat caccaaactg aagaaatctg tgttcaatgg actgaaccgt atgattgtca
      601 tagaactggg cggcaaccca ctgaaaaact ctgggattga aaatggagcc ttgcagggaa
      661 tgaagggtct cggatacatc cgcatctcag acaccaacat aactgctatt cctcaaggtc
      721 tgcccacttc tatcagtgaa ctgcatctgg atggcaacaa gatcgccaaa gttgatgcag
      781 ccagcctgaa aggaatgtct aatttgtcta agctgggttt gagcttcaat agcatcaccg
      841 ttgtggaaaa tggcagtctg gctaatgttc ctcatctgag ggagctccac ttggacaaca
      901 acaaactcct cagagtgcct gctgggctgg cacagcataa atatgtccag gtcgtctacc
      961 ttcataacaa caacatctcc gaagttgggc agcatgactt ctgcctccct tcataccaga
     1021 ctaggaagac ttcctacact gccgtgagtc tttatagcaa ccctgtccgg tattggcaaa
     1081 ttcacccaca caccttcaga tgtgtcttcg ggcgctctac cattcaactt gggaactaca
     1141 agtaactccc aaacagcctc atttttataa tcgggaacaa aaaaaccaat ctgtcaatat
     1201 tattgctaaa aagaaaaaaa tattttgaaa aagaaagaat gctagattct ggaaattcaa
     1261 gtatagcgcg gatgcctttc ccgtatgact tatcatgcat caagccaaat atacagattg
     1321 aataattacc tacaataaaa atattttatc tgtagtattc agaatcactt ttaaaatttt
     1381 ctgtagatgt gaactgaggt atcgaagtct ggtgtaatca tagatgtcaa catttaataa
     1441 agctaaaagg aacagaatac aaagtcttct gtaattcata gagctaaatt gactcttttg
     1501 acataaagtc aaatgtagaa ctctagcaat gtattaatct cctttattat tggtaaagtc
     1561 ttatttgaat atctaagttc aacatgggct atgtaaaatt ttcactgtca tactgaaaaa
     1621 caataaaatt taaaaaatgc attcaaaa
//
LOCUS       NM_001437724            2112 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus RNA binding motif protein 43 (Rbm43), mRNA.
ACCESSION   NM_001437724 XM_063283542
VERSION     NM_001437724.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063283542.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360172.1657478.1,
                                    SRR26360194.2284316.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN12840107,
                                    SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000003.1  56813887-56813931   c
            46-164              JAXUCZ010000003.1  56811314-56811432   c
            165-354             JAXUCZ010000003.1  56809119-56809308   c
            355-434             JAXUCZ010000003.1  56805970-56806049   c
            435-2112            JAXUCZ010000003.1  56803587-56805264   c
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2112
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA binding motif protein 43"
                     /db_xref="GeneID:311020"
                     /db_xref="RGD:1306676"
     exon            1..45
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            46..164
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    87..89
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="upstream in-frame stop codon"
     CDS             162..1193
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="rCG37778-like"
                     /codon_start=1
                     /product="RNA-binding protein 43"
                     /protein_id="NP_001424653.1"
                     /db_xref="GeneID:311020"
                     /db_xref="RGD:1306676"
                     /translation="MASALTVKDPTVSERTVVVSGLPVGLSKDQLVKRYFRDEGGHVE
                     KVIYPPRSKGVAYIIFKEKKVAQTIIRQKKHPLGSEPLLTVSHFSEKVFNYVMAILDL
                     SVFRPQIVLESLVVDLKKKIPTLNFSPLGRSGKISVQGSFLAILKLKQALISKAISAL
                     ENNRKYAGERRNWTGQNPRRVLQKNENSAPTLGTSVPEPAGSPETLVLDTDVFLYLKH
                     KCQFYEPTLSKYHVLCQERVDGDITTLCLQDARDGSYPGSVRHVKELIEEWAQEFYLE
                     LRKELLVLEGRRESEKRNMRQAFEQLCCRYPRVLMNVHRTHIDLIGPPSDTSLFKTQL
                     MKSAGQKVT"
     misc_feature    204..407
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    204..407
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    669..761
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            165..354
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            355..434
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            435..2112
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttttagg ccttcccgct gcctgagcat ctcctccctg cccaggtagg acctgcgtgc
       61 catctcatct tgactcagct actggttgaa aggacagcga ttccgagacc ctgcatcttc
      121 tgggccatca ccaccaccgc cttagttttc tgaattccac gatggcatca gcgttgacgg
      181 tcaaagatcc cacagtttct gagagaacag ttgtagtttc tgggcttcca gtcggcctct
      241 caaaagacca gttagtgaag cgctacttcc gggatgaggg cggacatgtg gaaaaggtga
      301 tatatccacc aagatccaaa ggagttgcgt atatcatctt caaggaaaag aaagttgcac
      361 agaccatcat cagacaaaag aaacaccctc taggctcaga gcctctgctc acagtctctc
      421 acttcagtga aaaggtcttc aactatgtga tggccattct tgatttgtct gtttttcggc
      481 ctcagattgt gctagaaagc ctagtagtag acctgaaaaa gaaaatccca actttaaatt
      541 ttagcccatt gggacgcagt gggaaaatct ctgtgcaagg ttcatttctg gccatcctga
      601 agctcaaaca ggctttgata tcaaaagcta tttccgcttt agaaaacaac aggaaatacg
      661 ctggtgagag gagaaactgg actggacaga accctagacg ggtcctgcag aaaaacgaga
      721 actctgcacc gactctgggg acctctgtac ctgagcctgc cggcagcccg gagacacttg
      781 tgcttgatac agatgttttt ctttacttga aacacaagtg tcagttttat gaaccaacgc
      841 tgagcaaata ccatgtcctg tgtcaggaaa gggtggatgg tgacatcact accctttgtc
      901 tacaagatgc ccgggatggg tcttaccctg gcagcgtcag acatgtgaag gagctcattg
      961 aggagtgggc ccaggagttc taccttgagc tcagaaaaga gctgctggtt ttggaaggaa
     1021 ggagagagag cgagaaaaga aacatgaggc aggcttttga acaactgtgt tgcagatatc
     1081 ctagagtttt gatgaatgtt cacagaacac atattgacct tataggacct ccttctgaca
     1141 cgtccctgtt taagacacag ctcatgaagt ctgcagggca aaaggtcact tgaagtctcg
     1201 gccacagtta tcatggtcac tccccccccg cccctccccc acccagggtg taggtgaaga
     1261 tttggatatg aagatatgga tatgaaacta cttatccggg ctggagagat ggctcagcgg
     1321 ttaagagcac ccgactgctc ttccagaggt catgagttca attcccagca accacatggt
     1381 ggctcacaac catctgtaat gagatctgat gccctcttct ggtgtatctg aagacagcta
     1441 cagtgtactt atatataata aatgaataaa tctttgaaaa aaaaaaaaga aactacttat
     1501 ccaaagttat ccagtagaca gtgaatggga ctggcattga ataaaaagta atgtctaaat
     1561 caagccttga aaaaaagaac tcactaaatg ttgactgatt tcccctgcaa atcaaaatta
     1621 ttaggagaag aagtcttccc ttgcataggt ttgcatgact agtgtgctgt tgctaagctc
     1681 tcggggtttg tattcacccc acatagcatt agaatgttgg ccgagctcac ttgggaagtt
     1741 gtggttctgt cagaattgtg ggggaatctt gggagaagtc tgtgtgaacg cttttgtgtg
     1801 tgcttcttgc tttccgatag tatggcatcc agatgagcat tgtgagtcga aaacattgtg
     1861 aatcagaaat gcctttaatt caagtagttt gcagaacatg ctagatttgc caaactgccc
     1921 acagtgagga gatgactgcg tacccgggtt gctgcgttga ctgacagata ggctcagtga
     1981 tgctgctctg cactgcttga cagcattggg tagtggatca gcacttgttt ggaagagatt
     2041 cagtgttcga agtacgattt ctactgactc tttattcctt ttgcaccgta ataaaggaaa
     2101 acgtacagaa ga
//
LOCUS       NM_001437685            5032 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 5,
            mRNA.
ACCESSION   NM_001437685 XM_039087891
VERSION     NM_001437685.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5032)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5032)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 5032)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 5032)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 5032)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5032)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 5032)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 5032)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 5032)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 5032)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087891.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.67906.1,
                                           SRR26360176.1828767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-449             JAXUCZ010000011.1  98105694-98105740
            450-521             JAXUCZ010000011.1  98106090-98106161
            522-608             JAXUCZ010000011.1  98108322-98108408
            609-771             JAXUCZ010000011.1  98109928-98110090
            772-892             JAXUCZ010000011.1  98113029-98113149
            893-1024            JAXUCZ010000011.1  98115531-98115662
            1025-1231           JAXUCZ010000011.1  98117537-98117743
            1232-1352           JAXUCZ010000011.1  98123938-98124058
            1353-1508           JAXUCZ010000011.1  98124251-98124406
            1509-1598           JAXUCZ010000011.1  98124558-98124647
            1599-1691           JAXUCZ010000011.1  98126328-98126420
            1692-1748           JAXUCZ010000011.1  98128415-98128471
            1749-1826           JAXUCZ010000011.1  98129086-98129163
            1827-1859           JAXUCZ010000011.1  98129443-98129475
            1860-2054           JAXUCZ010000011.1  98131039-98131233
            2055-2164           JAXUCZ010000011.1  98131384-98131493
            2165-2324           JAXUCZ010000011.1  98133415-98133574
            2325-5032           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..5032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5032
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2381
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 5 is encoded by transcript variant 5;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 5"
                     /protein_id="NP_001424614.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWRVEAEEWGKFLHT
                     KNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVP
                     VGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLA
                     VITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQ
                     KKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDD
                     KSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGG
                     LNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQ
                     HCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFA
                     DACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLI
                     QDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPI
                     MPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAV
                     MHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIA
                     EIRETHLW"
     misc_feature    135..137
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    306..314
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    885..896
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1182..1619
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Middle domain.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1494..2225
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Interaction with GSK3B.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1656..1859
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: B domain. /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1719..1943
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1737..1739
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1794..1796
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1923..1925
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1926..1928
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1959..1961
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q8K1M6; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    1989..1991
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2016..2018
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:17301055,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2079..2081
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CAMK1 and PKA.
                     /evidence=ECO:0000269|PubMed:28463107; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2088..2360
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2088..2360
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2130..2174
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Important for homodimerization.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..449
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..521
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..608
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..892
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1024
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1231
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1352
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1508
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1598
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1691
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1748
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1826
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1859
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2054
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2164
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2324
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..5032
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gagagttgaa gcagaagaat
      421 ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa attcgacaag
      481 aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc cctgagccaa
      541 tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat ttaccaggaa
      601 tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc agagaactta
      661 ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct gcaaatacag
      721 atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat gggcgcagaa
      781 ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc atggatgtat
      841 tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac aggagccaac
      901 tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat gcttttcttc
      961 aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct aggactctga
     1021 ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca agaataaatg
     1081 tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg gatgataaaa
     1141 gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac actattgaag
     1201 gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt tgttatattt
     1261 tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc cttaacacta
     1321 ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta tttgtgcctg
     1381 aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag cccagcctcc
     1441 gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt agcaactaca
     1501 gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa gtagtgactt
     1561 gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta gtggcaattg
     1621 agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg ctaatgaaca
     1681 ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc gctgtatcgc
     1741 gagacaagtc ttctaaagtt ccaagtgctt tggcacctgc ctcccaggag ccctcccctg
     1801 ccgcttctgc cgaggctgat ggcaagttaa ttcaggacaa cagaagagaa actaaaaatg
     1861 ttgcatctgc aggtggtgga attggagatg gtggtcgaat tggagatggt ggtcaggaac
     1921 cgacaacagg caactggaga ggaatgctga aaacttcaaa agctgaagaa ttacttgctg
     1981 aagaaaaatc aaaaccaatt ccaattatgc cagcaagtcc acaaaaaggc catgctgtca
     2041 atttgctaga tgtgccagtt ccagttgcac gaaaactgtc tgcccgagaa cagcgagatt
     2101 gtgaggttat tgaaagactc atcaaatcat attttctaat tgtcagaaag aatattcaag
     2161 acagcgtccc aaaggcagta atgcattttt tggttaatca tgtgaaagat actcttcaga
     2221 gtgaattagt agggcagctg tataagtcat ccttattaga tgaccttctg actgaatccg
     2281 aggacatggc acagcgaaga aaagaagcgg ctgacatgct gaaggcatta caaggagcca
     2341 gtcaaattat tgctgaaatc cgagagactc atctttggtg aacagaactg tttggtcttc
     2401 tacactttgc tgacttgaac ctactagcta ctgcctacct gagtagaaat ttatttatgg
     2461 acttttgtgt atcgcagtgt atgaatttgc ttgtgtgaag actggctata agctgaaaag
     2521 tatattattc attacaagac aaatcacatg tttaattcac atttttcaag tttcctatga
     2581 tgtatatcaa gtctgtccgt ttcagtcaaa cttacaagaa caattgatgt tctagttgta
     2641 caaagcagtt tgcctgtgca tatgatgacc tgcgtaacct ttttttagtc ttaaagctgc
     2701 agccgtagtc ctcaaagagg aagctccagg acatttcatg actataatgc atgcactatt
     2761 tatatagact gacctggctt caaaaggtgg agcctggcga gttcctcaca taatcaatgt
     2821 atccacctat ccttcatttt tatagtctta aaaaacaaac aaaattctga aacttctgca
     2881 gttttaggaa aaatataaga tctgaaagac tcataaagat gtaggaacag actgtgtaat
     2941 taatggctcc tgagtctata ctgccctaat gttagaaagt aaaatatgct ttgattcaaa
     3001 ataagcctga aaatataaat tgacttcctg cattaaaaat aactattagg aactttctta
     3061 gtaacaataa ctggtcctgt tagtttctaa atgactcagt gacaacctaa atttccctaa
     3121 tttacaagta catcgattgc agtccagatg caccttaggg tggggcgctg actctgggct
     3181 ccgagactca gttatgtgag acctaaaagt ctactctgta tccactggta atgctacttt
     3241 atagttccac accaacagaa tacatttgtc aaagaaaaat acctggacat acacatacac
     3301 ctaaaagctt atggactact aaactgtatt caggggttga ggatttacaa cctattttgt
     3361 gaaaactgcc tgtgcaattc aatttctgac ctagctgggc agtggtggtg cacaccttta
     3421 atcccagctt ttgggaggca gaggcaggtg gatctctgag ttcaaggcca gcctggtcta
     3481 cagagttgag ttccaagaca accagaacta cacagagaaa ccctgtcttg aacccccctc
     3541 cccccaaaaa attgaaacct aaatagaaat ctttgatgta tctagttttc tctgaccaaa
     3601 tgatacattt gtgttataaa tactaaaatt cttttcaggt caggcatctt atgaaatact
     3661 attagcaagg aaaacaagaa catgttatct ttagtttaga tgcccattga accatctcaa
     3721 aaacaaaggc agtctgataa cagtaccagc ttgacagtga gtatacactg cctaaatgtg
     3781 ttagcatact taagaaaaat atcctgttat ctaactatta ggtatccatg gtttattttt
     3841 taagagagat gaccaccact gtagcctttt gaatttgtaa agagaaagaa tgcaccttta
     3901 tccaacattt caaatagatt ttaaaaggaa gatgttagct ttaaaaacgt gctatgataa
     3961 tgtacttgtt agcactacac actttgtaca aagaaaaaca agcaagaaag gtagggaaat
     4021 gaaagcttcc tttgtgtact tttacactaa gctgtgttct gaaacatgga gataatttat
     4081 aagaccactg tatgttctat gtaaataaaa atgctggtgt gaaatggcat tacggtttgc
     4141 cagtaagtga attcttcctg acttgccgta agagagaggt ttaaataggt gcatctttga
     4201 aatatctgaa tctacttcat aatggaacga tttaaattgt actgcaccaa aagttttatg
     4261 ccattttttt aattagataa tcaccaccaa ggccttgtta catctttgtg tctacagatg
     4321 aagacagaaa cttcttccaa gtaatccaag gatgaatgct gagaacatga actttgctgc
     4381 aagacgtcta gaagctgatc cacagtttat gtttcacccc tatgtacatt ggggtggtgc
     4441 tatcttgatt tttacagaaa ctgtttttga gaattagctt gccttgtgta tacaaacctg
     4501 aactagtttg acttcaaaac ttcctgtatc ttttctgttc ttactgactg catacttgat
     4561 gagatacttt ttgtttcttt ggtttcttaa aatatctgct ataggaaccc actggcaaaa
     4621 ataggcagtt atcagtaaat tattgaaaca cagaacaagg aagtggaaaa ctgaactata
     4681 aatgaagtct ggtactgatt gatgttttgt tttaagaaaa aactattttg tactacagtt
     4741 tctattggga accactgcca tatctaactc ctttttaaga attctgtttg cttggcagca
     4801 tcaatcagaa gtttaacttt gtaacagatt tctcacatct aaacagacat tagaagcttg
     4861 gccagtttgt acagctatgt aacacaactg caatcaggtg cttaccttac ctcctgtgtt
     4921 aactttatac agtcatttcc actgcaccac ttcttcagac caaggagcaa gaaagatcat
     4981 tcttgcataa agaaatgaac tataattaaa tatcacttta ttttgaaatg ca
//
LOCUS       NM_001437707            3293 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 5, mRNA.
ACCESSION   NM_001437707 XM_039087929
VERSION     NM_001437707.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3293)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3293)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3293)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3293)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3293)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3293)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087929.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.46680.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000011.1  48369318-48369425   c
            109-210             JAXUCZ010000011.1  48315298-48315399   c
            211-298             JAXUCZ010000011.1  48308534-48308621   c
            299-516             JAXUCZ010000011.1  48198562-48198779   c
            517-668             JAXUCZ010000011.1  48179141-48179292   c
            669-872             JAXUCZ010000011.1  48168955-48169158   c
            873-953             JAXUCZ010000011.1  48168156-48168236   c
            954-1025            JAXUCZ010000011.1  48166329-48166400   c
            1026-1094           JAXUCZ010000011.1  48158807-48158875   c
            1095-1151           JAXUCZ010000011.1  48158140-48158196   c
            1152-1199           JAXUCZ010000011.1  48157502-48157549   c
            1200-3293           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3293
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..108
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            109..210
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     exon            211..298
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1720
                     /gene="Erg"
                     /note="isoform 5 is encoded by transcript variant 5; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 5"
                     /protein_id="NP_001424636.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MIQTVPDPEAQIKEALSVVSEDQSLFECAYGTPHLAKTEMTASS
                     SSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVG
                     SPDTVGMSYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLL
                     DVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKA
                     LQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSTWTGHSHPTPQ
                     SKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNS
                     NCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKR
                     YAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSS
                     SFFATPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY"
     misc_feature    623..874
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    623..874
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1208..1459
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1208..1459
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            299..516
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            517..668
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            669..872
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            873..953
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1025
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1094
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1151
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1199
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..3293
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctgccc ggcccggccc ggcatgtgcg tgggcacacg cgggcgcgga cacgcgcggg
       61 cacccacgag ctggacagac cctccccgac ggcagcaccg ggctctgggt tgttctaaga
      121 tctttggtga cctgagaaaa gctgtgttgg tcaagagcaa gacaaatgac tcccagagag
      181 aaaggatggc gaaaccaagg acaatcagag ctgtcccggg ttctacacag ctggtgaggg
      241 agctggcctg ctgaaggtca tgatccagac tgttcctgac ccagaagctc agattaagga
      301 ggccttgtca gttgtgagcg aggaccagtc actatttgag tgtgcctacg gaacgccaca
      361 cctggctaag acagaaatga ccgcatcctc ttccagtgac tatggccaga catccaagat
      421 gagtcccaga gtcccacaac aggactggct gtctcagccc ccagccaggg tcaccatcaa
      481 gatggagtgc aaccctagcc aggtgaacgg ttccaggaac tcacctgacg aatgcagtgt
      541 gaccaaaggt gggaagatgg tgggcagccc tgatactgtg ggaatgagct acggcagcta
      601 catggaggag aagcacatgc cgccccccaa tatgaccacg aatgaacgca gagtgatcgt
      661 ccctgcagat cctactctgt ggagcacaga ccatgtccgg cagtggctgg agtgggcagt
      721 gaaagaatac ggcctcctag acgtggacgt cttattattt cagaatattg acgggaagga
      781 gctgtgcaag atgacaaaag atgacttcca gaggctcact ccgagctaca atgccgacat
      841 tcttctctca catctccact acctcagaga gactcccctt ccacatctga catccgacga
      901 cgttgataag gctttacaaa actctccacg gttaatgcat gctagaaaca cagggggtgc
      961 agcttttatt ttccccaata cttcagtata tcccgaagcc acgcagagaa ttacaactag
     1021 gccagattta ccttatgagc ctcccaggag atcaacctgg accggccaca gccaccccac
     1081 ccctcagtcc aaagctgccc agccatctcc ctccacagtg cccaaaactg aagaccagcg
     1141 tcctcagtta gatccttacc agatcctggg acccaccagt agtcgccttg ctaatccagg
     1201 tagtggccag atccagctgt ggcagttcct gctagaactc ctgtctgaca gctccaactc
     1261 caactgcatc acctgggaag gcaccaacgg ggagttcaag atgacagacc cggatgaggt
     1321 ggctcggcgc tggggggagc ggaagagcaa gcccaacatg aactatgaca aactcagccg
     1381 tgccctccgc tactactacg acaaaaacat catgaccaag gtgcatggga agcgctatgc
     1441 ctacaagttt gacttccacg ggattgccca ggccctgcag ccccatcccc ccgagtcgtc
     1501 cctgtacaag tacccctccg acctgccgta catgggctcc tatcacaccc acccccagaa
     1561 gatgaacttt gtggctcccc accctccggc cctcccagtc acatcttcca gtttctttgc
     1621 taccccgaac ccatactgga attcgccgac tgggggcatc tacccgaaca ctaggctccc
     1681 agccagccat atgccctctc acctgggcac ctactactag agaccagata gaggcctttc
     1741 ccaacagtgc acaatcgcct agcaatcacc acaaactcag agaacacaaa tcgaaagtgc
     1801 ctcctgagga atggaaacgg ttggccagag ctggggaagg aagccgggga aagaaaacca
     1861 aagactcaca ggggagggtg ggcaccaccc aagtattact acagaaatag aagaagctca
     1921 aaatatactg tacatggaca tataacctgt ggtccaccct tgtcaaagac attgtatgta
     1981 gaaaagcgtg accgagaaga acaactgtcc aaggaagtgg ccttaagtag tgtacaaact
     2041 gtagagtgtg ggaccttgct tgtaccagga ttcagtgaga gcaatagaac cataacagtc
     2101 ttggcctagc acaccatcac gtgtgatgac atttgaaggg aaactacctg tgtttaaaaa
     2161 cagaaaaaaa catatccaaa ccaaataaga agaggaaaaa aaaaaaaaga tggcggcccc
     2221 tccacagacc acaatggctg tggattttct tggctggcat ttgctgtttt cattgaaatc
     2281 aggttcgttc catttgatag ggagctgcca gctctgtcaa actgtgaaga tgacccagcg
     2341 tctcatcacc ttttcagtat tacgggaaat gtgggccatg tggtgggcgg ggaatgtatg
     2401 tgcatgttgt tgtgagtatg tgatcataga agaaagactg aaacggagga agagatagag
     2461 gatcaggggt tggggaggga gttaagggag aggaggaagt ggaagaggaa gaggaggagg
     2521 gaggaggaga aagggggagg aagaaaagga ggaagaggag aaaggaggag gaagaaaagg
     2581 agaaaatgag gaagagaagg aaaagaagaa aagaaggggg aggaagagga gaaggaggaa
     2641 gaggaagaga ggaagagaag caagctgctc aagccaccac agctgaattt aggacatctt
     2701 gggaccaaag agcatgagtc aagatgtttg atgctgccag ggttgtaaga aaggacacag
     2761 atttgtggag gactgggagc agtagtattc agaaccaaaa atatgtctct ttgtgaaaag
     2821 gaaatcataa ctggaattgt ctgatattta aaaaattcag gacctcagta ttcaatggag
     2881 gctttgtcct tcacaggggg cagttgagag gtgaccttgg tggctaccat ggtcagagac
     2941 cacacaggca ttgtgggtag gtgggctcca gttttcctta atgagtcgcg aacgctgtgc
     3001 gttcgtcaga acgaagtcta caagtcaatg gtttttttct ttttatataa taattatata
     3061 acttatgcat ttatacacta cgagttgacc tcggccagcc aaagacacca cacacacaca
     3121 cacacacaca cacacacaca cacacacaca cacaaaagag acaatcaaac atatgatgtg
     3181 gccttgaatt ttaactctgt aatgcttaat gtttacaata tgaagttact agttcttaga
     3241 atgcagaatg tatgttaata aaaatgagct tggcctctca tggcgaacca gaa
//
LOCUS       NM_001437693            4942 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 13,
            mRNA.
ACCESSION   NM_001437693 XM_039087899
VERSION     NM_001437693.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4942)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4942)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4942)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4942)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4942)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4942)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4942)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4942)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4942)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4942)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087899.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.30247.1,
                                           SRR26643289.31603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-423             JAXUCZ010000011.1  98104416-98104454
            424-470             JAXUCZ010000011.1  98105694-98105740
            471-542             JAXUCZ010000011.1  98106090-98106161
            543-629             JAXUCZ010000011.1  98108322-98108408
            630-792             JAXUCZ010000011.1  98109928-98110090
            793-913             JAXUCZ010000011.1  98113029-98113149
            914-1045            JAXUCZ010000011.1  98115531-98115662
            1046-1252           JAXUCZ010000011.1  98117537-98117743
            1253-1373           JAXUCZ010000011.1  98123938-98124058
            1374-1529           JAXUCZ010000011.1  98124251-98124406
            1530-1619           JAXUCZ010000011.1  98124558-98124647
            1620-1712           JAXUCZ010000011.1  98126328-98126420
            1713-1769           JAXUCZ010000011.1  98128415-98128471
            1770-1964           JAXUCZ010000011.1  98131039-98131233
            1965-2074           JAXUCZ010000011.1  98131384-98131493
            2075-2234           JAXUCZ010000011.1  98133415-98133574
            2235-4942           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4942
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2291
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 13 is encoded by transcript variant 13;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 13"
                     /protein_id="NP_001424622.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEE
                     WGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDL
                     PGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDP
                     DGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIR
                     DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNS
                     YGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLE
                     SVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHE
                     EMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYIN
                     TKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKVASAGGGIGDGGRIGDGGQEP
                     TTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQR
                     DCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLL
                     TESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1998..2270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1998..2270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..423
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..470
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..542
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..629
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..792
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..913
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1045
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1252
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1373
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1529
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1619
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1712
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1769
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1964
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2074
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2234
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..4942
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatgaccctg ctacatggaa aaactcaaga cacctttcta
      421 aaggagttga agcagaagaa tggggtaaat ttcttcacac caaaaacaag ctttacacag
      481 attttgatga aattcgacaa gaaattgaaa atgaaactga aagaatttca ggaaataata
      541 agggagtaag ccctgagcca atccatctca aggttttctc gcccaacgtt gtcaacctga
      601 cgcttgtgga tttaccagga atgaccaaag tacctgtagg tgatcagccc aaggatattg
      661 agcttcaaat cagagaactt attcttcggt tcatcagtaa tcccaattcc attatccttg
      721 ctgtcactgc tgcaaataca gatatggcaa cgtcagaggc acttaagatt tccagagagg
      781 tagatccaga tgggcgcaga actctagctg taatcaccaa gcttgatctc atggatgcgg
      841 gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaagctt ggaataattg
      901 gagtagttaa caggagccaa ctggacatta acaataagaa gagtgtaact gattcaatcc
      961 gtgatgagta tgcttttctt caaaagaagt acccatctct ggccaacaga aatggaacaa
     1021 agtatcttgc taggactctg aataggttac ttatgcatca tatcagagac tgtttaccag
     1081 agctgaaaac aagaataaat gtcttagctg ctcagtatca gtctcttcta aatagctatg
     1141 gtgagcccgt ggatgataaa agtgctactt tactccagct cattaccaag tttgccacag
     1201 agtattgtaa cactattgaa ggaacggcaa agtacattga aacttctgag ctatgtggtg
     1261 gtgctaggat ttgttatatt ttccatgaga cttttgggcg aaccttagaa tctgttgatc
     1321 cactaggtgg ccttaacact attgacatct tgaccgccat tagaaatgct actggccccc
     1381 gtccagcttt atttgtgcct gaagtttcat ttgagttact ggtcaaacgt cagattaagc
     1441 gtctagagga gcccagcctc cgctgtgtgg agctggtcca cgaggaaatg cagaggatca
     1501 ttcagcactg tagcaactac agcacacagg aactgttacg gttccctaaa ctccatgatg
     1561 ccatagttga agtagtgact tgtcttcttc gtaaaaggtt gcccgtgaca aatgaaatgg
     1621 tacataactt agtggcaatt gagctagcat atatcaacac aaaacacccc gactttgctg
     1681 atgcctgtgg gctaatgaac aataacatag aggaacaaag aagaaacaga ctagcaagag
     1741 aactaccttc cgctgtatcg cgagacaagg ttgcatctgc aggtggtgga attggagatg
     1801 gtggtcgaat tggagatggt ggtcaggaac cgacaacagg caactggaga ggaatgctga
     1861 aaacttcaaa agctgaagaa ttacttgctg aagaaaaatc aaaaccaatt ccaattatgc
     1921 cagcaagtcc acaaaaaggc catgctgtca atttgctaga tgtgccagtt ccagttgcac
     1981 gaaaactgtc tgcccgagaa cagcgagatt gtgaggttat tgaaagactc atcaaatcat
     2041 attttctaat tgtcagaaag aatattcaag acagcgtccc aaaggcagta atgcattttt
     2101 tggttaatca tgtgaaagat actcttcaga gtgaattagt agggcagctg tataagtcat
     2161 ccttattaga tgaccttctg actgaatccg aggacatggc acagcgaaga aaagaagcgg
     2221 ctgacatgct gaaggcatta caaggagcca gtcaaattat tgctgaaatc cgagagactc
     2281 atctttggtg aacagaactg tttggtcttc tacactttgc tgacttgaac ctactagcta
     2341 ctgcctacct gagtagaaat ttatttatgg acttttgtgt atcgcagtgt atgaatttgc
     2401 ttgtgtgaag actggctata agctgaaaag tatattattc attacaagac aaatcacatg
     2461 tttaattcac atttttcaag tttcctatga tgtatatcaa gtctgtccgt ttcagtcaaa
     2521 cttacaagaa caattgatgt tctagttgta caaagcagtt tgcctgtgca tatgatgacc
     2581 tgcgtaacct ttttttagtc ttaaagctgc agccgtagtc ctcaaagagg aagctccagg
     2641 acatttcatg actataatgc atgcactatt tatatagact gacctggctt caaaaggtgg
     2701 agcctggcga gttcctcaca taatcaatgt atccacctat ccttcatttt tatagtctta
     2761 aaaaacaaac aaaattctga aacttctgca gttttaggaa aaatataaga tctgaaagac
     2821 tcataaagat gtaggaacag actgtgtaat taatggctcc tgagtctata ctgccctaat
     2881 gttagaaagt aaaatatgct ttgattcaaa ataagcctga aaatataaat tgacttcctg
     2941 cattaaaaat aactattagg aactttctta gtaacaataa ctggtcctgt tagtttctaa
     3001 atgactcagt gacaacctaa atttccctaa tttacaagta catcgattgc agtccagatg
     3061 caccttaggg tggggcgctg actctgggct ccgagactca gttatgtgag acctaaaagt
     3121 ctactctgta tccactggta atgctacttt atagttccac accaacagaa tacatttgtc
     3181 aaagaaaaat acctggacat acacatacac ctaaaagctt atggactact aaactgtatt
     3241 caggggttga ggatttacaa cctattttgt gaaaactgcc tgtgcaattc aatttctgac
     3301 ctagctgggc agtggtggtg cacaccttta atcccagctt ttgggaggca gaggcaggtg
     3361 gatctctgag ttcaaggcca gcctggtcta cagagttgag ttccaagaca accagaacta
     3421 cacagagaaa ccctgtcttg aacccccctc cccccaaaaa attgaaacct aaatagaaat
     3481 ctttgatgta tctagttttc tctgaccaaa tgatacattt gtgttataaa tactaaaatt
     3541 cttttcaggt caggcatctt atgaaatact attagcaagg aaaacaagaa catgttatct
     3601 ttagtttaga tgcccattga accatctcaa aaacaaaggc agtctgataa cagtaccagc
     3661 ttgacagtga gtatacactg cctaaatgtg ttagcatact taagaaaaat atcctgttat
     3721 ctaactatta ggtatccatg gtttattttt taagagagat gaccaccact gtagcctttt
     3781 gaatttgtaa agagaaagaa tgcaccttta tccaacattt caaatagatt ttaaaaggaa
     3841 gatgttagct ttaaaaacgt gctatgataa tgtacttgtt agcactacac actttgtaca
     3901 aagaaaaaca agcaagaaag gtagggaaat gaaagcttcc tttgtgtact tttacactaa
     3961 gctgtgttct gaaacatgga gataatttat aagaccactg tatgttctat gtaaataaaa
     4021 atgctggtgt gaaatggcat tacggtttgc cagtaagtga attcttcctg acttgccgta
     4081 agagagaggt ttaaataggt gcatctttga aatatctgaa tctacttcat aatggaacga
     4141 tttaaattgt actgcaccaa aagttttatg ccattttttt aattagataa tcaccaccaa
     4201 ggccttgtta catctttgtg tctacagatg aagacagaaa cttcttccaa gtaatccaag
     4261 gatgaatgct gagaacatga actttgctgc aagacgtcta gaagctgatc cacagtttat
     4321 gtttcacccc tatgtacatt ggggtggtgc tatcttgatt tttacagaaa ctgtttttga
     4381 gaattagctt gccttgtgta tacaaacctg aactagtttg acttcaaaac ttcctgtatc
     4441 ttttctgttc ttactgactg catacttgat gagatacttt ttgtttcttt ggtttcttaa
     4501 aatatctgct ataggaaccc actggcaaaa ataggcagtt atcagtaaat tattgaaaca
     4561 cagaacaagg aagtggaaaa ctgaactata aatgaagtct ggtactgatt gatgttttgt
     4621 tttaagaaaa aactattttg tactacagtt tctattggga accactgcca tatctaactc
     4681 ctttttaaga attctgtttg cttggcagca tcaatcagaa gtttaacttt gtaacagatt
     4741 tctcacatct aaacagacat tagaagcttg gccagtttgt acagctatgt aacacaactg
     4801 caatcaggtg cttaccttac ctcctgtgtt aactttatac agtcatttcc actgcaccac
     4861 ttcttcagac caaggagcaa gaaagatcat tcttgcataa agaaatgaac tataattaaa
     4921 tatcacttta ttttgaaatg ca
//
LOCUS       NM_001437683            5053 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 3,
            mRNA.
ACCESSION   NM_001437683 XM_039087889
VERSION     NM_001437683.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5053)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5053)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 5053)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 5053)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 5053)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5053)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 5053)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 5053)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 5053)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 5053)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087889.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF019043.2, SRR26643298.67900.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-423             JAXUCZ010000011.1  98104416-98104454
            424-470             JAXUCZ010000011.1  98105694-98105740
            471-542             JAXUCZ010000011.1  98106090-98106161
            543-629             JAXUCZ010000011.1  98108322-98108408
            630-792             JAXUCZ010000011.1  98109928-98110090
            793-913             JAXUCZ010000011.1  98113029-98113149
            914-1045            JAXUCZ010000011.1  98115531-98115662
            1046-1252           JAXUCZ010000011.1  98117537-98117743
            1253-1373           JAXUCZ010000011.1  98123938-98124058
            1374-1529           JAXUCZ010000011.1  98124251-98124406
            1530-1619           JAXUCZ010000011.1  98124558-98124647
            1620-1712           JAXUCZ010000011.1  98126328-98126420
            1713-1769           JAXUCZ010000011.1  98128415-98128471
            1770-1847           JAXUCZ010000011.1  98129086-98129163
            1848-1880           JAXUCZ010000011.1  98129443-98129475
            1881-2075           JAXUCZ010000011.1  98131039-98131233
            2076-2185           JAXUCZ010000011.1  98131384-98131493
            2186-2345           JAXUCZ010000011.1  98133415-98133574
            2346-5053           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..5053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5053
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 3 is encoded by transcript variant 3;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 3"
                     /protein_id="NP_001424612.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEE
                     WGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDL
                     PGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDP
                     DGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIR
                     DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNS
                     YGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLE
                     SVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHE
                     EMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYIN
                     TKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASA
                     EADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEE
                     KSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQ
                     DSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQ
                     GASQIIAEIRETHLW"
     misc_feature    135..137
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1079
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,609..611,
                     819..821,825..830,906..920,927..929)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,621..623,660..662,735..737,741..743,
                     747..758,762..767,828..830,834..845,915..923)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    306..314
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    609..620
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(615..620,708..713)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    816..827
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    846..1703
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    906..917
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    906..914
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1203..1640
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Middle domain.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1515..2246
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Interaction with GSK3B.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1677..1880
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: B domain. /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1740..1964
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1758..1760
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1815..1817
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1944..1946
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1947..1949
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1980..1982
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q8K1M6; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    2010..2012
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2037..2039
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:17301055,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2100..2102
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CAMK1 and PKA.
                     /evidence=ECO:0000269|PubMed:28463107; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2109..2381
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2109..2381
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2151..2195
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Important for homodimerization.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..423
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..470
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..542
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..629
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..792
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..913
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1045
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1252
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1373
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1529
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1619
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1712
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1769
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1847
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1880
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2075
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2185
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2345
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..5053
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatgaccctg ctacatggaa aaactcaaga cacctttcta
      421 aaggagttga agcagaagaa tggggtaaat ttcttcacac caaaaacaag ctttacacag
      481 attttgatga aattcgacaa gaaattgaaa atgaaactga aagaatttca ggaaataata
      541 agggagtaag ccctgagcca atccatctca aggttttctc gcccaacgtt gtcaacctga
      601 cgcttgtgga tttaccagga atgaccaaag tacctgtagg tgatcagccc aaggatattg
      661 agcttcaaat cagagaactt attcttcggt tcatcagtaa tcccaattcc attatccttg
      721 ctgtcactgc tgcaaataca gatatggcaa cgtcagaggc acttaagatt tccagagagg
      781 tagatccaga tgggcgcaga actctagctg taatcaccaa gcttgatctc atggatgcgg
      841 gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaagctt ggaataattg
      901 gagtagttaa caggagccaa ctggacatta acaataagaa gagtgtaact gattcaatcc
      961 gtgatgagta tgcttttctt caaaagaagt acccatctct ggccaacaga aatggaacaa
     1021 agtatcttgc taggactctg aataggttac ttatgcatca tatcagagac tgtttaccag
     1081 agctgaaaac aagaataaat gtcttagctg ctcagtatca gtctcttcta aatagctatg
     1141 gtgagcccgt ggatgataaa agtgctactt tactccagct cattaccaag tttgccacag
     1201 agtattgtaa cactattgaa ggaacggcaa agtacattga aacttctgag ctatgtggtg
     1261 gtgctaggat ttgttatatt ttccatgaga cttttgggcg aaccttagaa tctgttgatc
     1321 cactaggtgg ccttaacact attgacatct tgaccgccat tagaaatgct actggccccc
     1381 gtccagcttt atttgtgcct gaagtttcat ttgagttact ggtcaaacgt cagattaagc
     1441 gtctagagga gcccagcctc cgctgtgtgg agctggtcca cgaggaaatg cagaggatca
     1501 ttcagcactg tagcaactac agcacacagg aactgttacg gttccctaaa ctccatgatg
     1561 ccatagttga agtagtgact tgtcttcttc gtaaaaggtt gcccgtgaca aatgaaatgg
     1621 tacataactt agtggcaatt gagctagcat atatcaacac aaaacacccc gactttgctg
     1681 atgcctgtgg gctaatgaac aataacatag aggaacaaag aagaaacaga ctagcaagag
     1741 aactaccttc cgctgtatcg cgagacaagt cttctaaagt tccaagtgct ttggcacctg
     1801 cctcccagga gccctcccct gccgcttctg ccgaggctga tggcaagtta attcaggaca
     1861 acagaagaga aactaaaaat gttgcatctg caggtggtgg aattggagat ggtggtcgaa
     1921 ttggagatgg tggtcaggaa ccgacaacag gcaactggag aggaatgctg aaaacttcaa
     1981 aagctgaaga attacttgct gaagaaaaat caaaaccaat tccaattatg ccagcaagtc
     2041 cacaaaaagg ccatgctgtc aatttgctag atgtgccagt tccagttgca cgaaaactgt
     2101 ctgcccgaga acagcgagat tgtgaggtta ttgaaagact catcaaatca tattttctaa
     2161 ttgtcagaaa gaatattcaa gacagcgtcc caaaggcagt aatgcatttt ttggttaatc
     2221 atgtgaaaga tactcttcag agtgaattag tagggcagct gtataagtca tccttattag
     2281 atgaccttct gactgaatcc gaggacatgg cacagcgaag aaaagaagcg gctgacatgc
     2341 tgaaggcatt acaaggagcc agtcaaatta ttgctgaaat ccgagagact catctttggt
     2401 gaacagaact gtttggtctt ctacactttg ctgacttgaa cctactagct actgcctacc
     2461 tgagtagaaa tttatttatg gacttttgtg tatcgcagtg tatgaatttg cttgtgtgaa
     2521 gactggctat aagctgaaaa gtatattatt cattacaaga caaatcacat gtttaattca
     2581 catttttcaa gtttcctatg atgtatatca agtctgtccg tttcagtcaa acttacaaga
     2641 acaattgatg ttctagttgt acaaagcagt ttgcctgtgc atatgatgac ctgcgtaacc
     2701 tttttttagt cttaaagctg cagccgtagt cctcaaagag gaagctccag gacatttcat
     2761 gactataatg catgcactat ttatatagac tgacctggct tcaaaaggtg gagcctggcg
     2821 agttcctcac ataatcaatg tatccaccta tccttcattt ttatagtctt aaaaaacaaa
     2881 caaaattctg aaacttctgc agttttagga aaaatataag atctgaaaga ctcataaaga
     2941 tgtaggaaca gactgtgtaa ttaatggctc ctgagtctat actgccctaa tgttagaaag
     3001 taaaatatgc tttgattcaa aataagcctg aaaatataaa ttgacttcct gcattaaaaa
     3061 taactattag gaactttctt agtaacaata actggtcctg ttagtttcta aatgactcag
     3121 tgacaaccta aatttcccta atttacaagt acatcgattg cagtccagat gcaccttagg
     3181 gtggggcgct gactctgggc tccgagactc agttatgtga gacctaaaag tctactctgt
     3241 atccactggt aatgctactt tatagttcca caccaacaga atacatttgt caaagaaaaa
     3301 tacctggaca tacacataca cctaaaagct tatggactac taaactgtat tcaggggttg
     3361 aggatttaca acctattttg tgaaaactgc ctgtgcaatt caatttctga cctagctggg
     3421 cagtggtggt gcacaccttt aatcccagct tttgggaggc agaggcaggt ggatctctga
     3481 gttcaaggcc agcctggtct acagagttga gttccaagac aaccagaact acacagagaa
     3541 accctgtctt gaacccccct ccccccaaaa aattgaaacc taaatagaaa tctttgatgt
     3601 atctagtttt ctctgaccaa atgatacatt tgtgttataa atactaaaat tcttttcagg
     3661 tcaggcatct tatgaaatac tattagcaag gaaaacaaga acatgttatc tttagtttag
     3721 atgcccattg aaccatctca aaaacaaagg cagtctgata acagtaccag cttgacagtg
     3781 agtatacact gcctaaatgt gttagcatac ttaagaaaaa tatcctgtta tctaactatt
     3841 aggtatccat ggtttatttt ttaagagaga tgaccaccac tgtagccttt tgaatttgta
     3901 aagagaaaga atgcaccttt atccaacatt tcaaatagat tttaaaagga agatgttagc
     3961 tttaaaaacg tgctatgata atgtacttgt tagcactaca cactttgtac aaagaaaaac
     4021 aagcaagaaa ggtagggaaa tgaaagcttc ctttgtgtac ttttacacta agctgtgttc
     4081 tgaaacatgg agataattta taagaccact gtatgttcta tgtaaataaa aatgctggtg
     4141 tgaaatggca ttacggtttg ccagtaagtg aattcttcct gacttgccgt aagagagagg
     4201 tttaaatagg tgcatctttg aaatatctga atctacttca taatggaacg atttaaattg
     4261 tactgcacca aaagttttat gccatttttt taattagata atcaccacca aggccttgtt
     4321 acatctttgt gtctacagat gaagacagaa acttcttcca agtaatccaa ggatgaatgc
     4381 tgagaacatg aactttgctg caagacgtct agaagctgat ccacagttta tgtttcaccc
     4441 ctatgtacat tggggtggtg ctatcttgat ttttacagaa actgtttttg agaattagct
     4501 tgccttgtgt atacaaacct gaactagttt gacttcaaaa cttcctgtat cttttctgtt
     4561 cttactgact gcatacttga tgagatactt tttgtttctt tggtttctta aaatatctgc
     4621 tataggaacc cactggcaaa aataggcagt tatcagtaaa ttattgaaac acagaacaag
     4681 gaagtggaaa actgaactat aaatgaagtc tggtactgat tgatgttttg ttttaagaaa
     4741 aaactatttt gtactacagt ttctattggg aaccactgcc atatctaact cctttttaag
     4801 aattctgttt gcttggcagc atcaatcaga agtttaactt tgtaacagat ttctcacatc
     4861 taaacagaca ttagaagctt ggccagtttg tacagctatg taacacaact gcaatcaggt
     4921 gcttacctta cctcctgtgt taactttata cagtcatttc cactgcacca cttcttcaga
     4981 ccaaggagca agaaagatca ttcttgcata aagaaatgaa ctataattaa atatcacttt
     5041 attttgaaat gca
//
LOCUS       NM_001437750            4330 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 9 member C1 (Slc9c1),
            transcript variant 4, mRNA.
ACCESSION   NM_001437750 XM_017597927
VERSION     NM_001437750.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4330)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   2  (bases 1 to 4330)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_017597927.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.69078.1,
                                           SRR26360181.1921354.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               JAXUCZ010000011.1  68740450-68740859   c
            411-541             JAXUCZ010000011.1  68739393-68739523   c
            542-795             JAXUCZ010000011.1  68738514-68738767   c
            796-896             JAXUCZ010000011.1  68737292-68737392   c
            897-1025            JAXUCZ010000011.1  68735441-68735569   c
            1026-1191           JAXUCZ010000011.1  68734127-68734292   c
            1192-1317           JAXUCZ010000011.1  68731230-68731355   c
            1318-1479           JAXUCZ010000011.1  68729739-68729900   c
            1480-1579           JAXUCZ010000011.1  68727024-68727123   c
            1580-1723           JAXUCZ010000011.1  68725462-68725605   c
            1724-1898           JAXUCZ010000011.1  68724252-68724426   c
            1899-1980           JAXUCZ010000011.1  68722851-68722932   c
            1981-2147           JAXUCZ010000011.1  68721131-68721297   c
            2148-2273           JAXUCZ010000011.1  68719387-68719512   c
            2274-2371           JAXUCZ010000011.1  68710052-68710149   c
            2372-2491           JAXUCZ010000011.1  68707948-68708067   c
            2492-2687           JAXUCZ010000011.1  68705164-68705359   c
            2688-2873           JAXUCZ010000011.1  68702161-68702346   c
            2874-3023           JAXUCZ010000011.1  68700108-68700257   c
            3024-3075           JAXUCZ010000011.1  68698708-68698759   c
            3076-3224           JAXUCZ010000011.1  68697254-68697402   c
            3225-3350           JAXUCZ010000011.1  68693952-68694077   c
            3351-3449           JAXUCZ010000011.1  68692683-68692781   c
            3450-3632           JAXUCZ010000011.1  68689006-68689188   c
            3633-3764           JAXUCZ010000011.1  68682499-68682630   c
            3765-3950           JAXUCZ010000011.1  68682196-68682381   c
            3951-4077           JAXUCZ010000011.1  68680194-68680320   c
            4078-4130           JAXUCZ010000011.1  68676184-68676236   c
            4131-4330           JAXUCZ010000011.1  68674380-68674579   c
FEATURES             Location/Qualifiers
     source          1..4330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4330
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
     exon            1..410
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            411..541
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            542..795
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    633..635
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="upstream in-frame stop codon"
     CDS             648..4193
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="isoform 1 is encoded by transcript variant 4;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; solute carrier family 9, member 10; solute
                     carrier family 9, subfamily C (Na+-transporting carboxylic
                     acid decarboxylase), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 10 isoform 1"
                     /protein_id="NP_001424679.1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
                     /translation="MEEVFENLTTTHNVKLSNAWLDLLKSVFLSTPQDLPEIILILSL
                     ICTIGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFFGI
                     FTPVIIFNVAFDMDIYMLQKLFWQILLITIPGFMINYTLILWYLQSVNKLSLKTIPWL
                     LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKH
                     MNHTLAHKVMSTAWSYLVESFITGILITKAIQLWMATIFGDDVNHITLIFSVLYLIFY
                     VCELIGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPA
                     HTYLYISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKG
                     TPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIVNRFILPMAVIKLGLRDVT
                     STKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTE
                     HQKVKCPDCNKEIDETLNIEAMELANRRLLSAQIASYQRQYRNEILSQSAMQVLVGAA
                     GSFGEKKGEYMSPENIKNYSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHS
                     IVFTNEFEYTGYIAVLMNTYPMIICWISRLKDIYQYEIKCANYYFLTFYILEALLKVA
                     AMRKEFFSHTWLLFELGITLVGILDIILIETDSISYKFDLTETVVFMNVVRLLRILRI
                     LKLITPKLLQVIDKRMSQQISFRYAILKGYVQGEMDVLNIIDQIASSKQAKQILLKRV
                     IRNMDHAMKELGYLEYDHPEIAVTMKTKEEVNVMLNMAREIVKAFRSKGIIHKVEGAE
                     INKLIMAKKKQVLELQSVIQPLNVEEAPYYIPWLSEDPEAISFIQEKAKVVTFDCGNN
                     IFEEGDEPEGIYVIISGMVKLKRSKPHLEMDRVSSESEVAQTRSYTLPHTEYLLSGEI
                     IGELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKKYPNMKYKMWQKIGLAITAQ
                     KIRENLSFEDWNYKMQLKLCNVFVRDIPKTTKTDIYDETVTHVVLIHGSAEDCQLRKI
                     YKAPFLIPVTCHQIQGLEEFTKVMIIQTSVAVRKFRWNVKKYNPPRRISMKPDSTESL
                     ETLNESSEDDEDKKENEENEEYLEDIIDISSVSKK"
     misc_feature    756..2315
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    756..2315
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    3324..3707
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    3324..3707
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(3567..3572,3597..3605)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3567..3572,3597..3605)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3663..3671,3684..3692)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3663..3671,3684..3692)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            796..896
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1025
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1191
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1317
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1479
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1579
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1723
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1898
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1980
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2147
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2273
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2371
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2491
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2687
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2873
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3023
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3075
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3224
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3350
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3449
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3632
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3764
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3950
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4077
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4130
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4330
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtcagt gaggttgcag ttggttttgg acagttctgg agtgagagga agttcctggc
       61 ctccacttct cacattctct aggacactcc tgtgccctgg atggtgagcc ctcctgttgt
      121 ttctctttct ggaagttgac ctttccatct ggtgcttgtt ctctggaccg cctctgttcg
      181 aagatcaaag gaagccactg tttagcttag agtcttggct cgcacttgtg ctttctcatt
      241 acaaccaaag actgtaagac caattgcctt agggcaaatt tctgtctcac cccttcaccg
      301 ttaaactttt tatcaggtct tgagaaacta ctcaccacca catggataat gacttcatat
      361 tgatgacgta cccagtagtc atgccctaaa agagagtggg gtggaagatg ctttccaagt
      421 gattcatgct actgctgaga tggagtctta ctggacagac atagctgaga gccgttgctc
      481 tatttccaga tcaacctcaa gctcttgttt tcttttgtga tttttttttt attattttga
      541 gaagggcatt aggaagacac caagaagaaa agtcctattc cctttgatcc cctgtgagtt
      601 tttcagagac acagagtttg agacgctgac tgtaattaaa tacgggaatg gaagaagttt
      661 ttgagaatct aactacaacc cacaatgtca aactgagtaa tgcatggctg gatcttctca
      721 aaagcgtgtt tttgagcact ccccaggacc tccctgaaat catcttgata ctatctttga
      781 tctgtacgat tggagcattt ttgaacatgc atctgaagga ttttccaatt cctcttcctg
      841 tgatactatt tttaattgga tgctgttttg aaattctgag ttttgcatct actcagatcc
      901 agttatatgc agatgccata cagtggatgg atcctgacat gttttttggg atatttacac
      961 cagtaattat ctttaatgtt gcatttgaca tggatatata catgcttcaa aagttatttt
     1021 ggcagatatt attaattaca attcctggat ttatgattaa ttacacctta atactgtggt
     1081 atctgcagtc tgtgaataaa ttatctttaa agaccatccc ctggctactg ttttcagctg
     1141 tgcttatcag ttcagatcct atgcttactt cagcctccat aagagacctt ggtctttcca
     1201 gaagcctcac aaatttaatt aacggagaga gtctactgac ctcagtgata tccttaatta
     1261 tatatagtgc tgttgtgcag atcagtttca agtcaaagca tatgaaccat accctagccc
     1321 ataaggtcat gtccacagct tggtcatatc ttgtggaaag tttcatcact ggaatcctaa
     1381 ttacaaaagc gattcagtta tggatggcta ccatctttgg tgatgacgtc aaccacatca
     1441 cgctcatctt ctcagttcta tacctcatct tctatgtttg tgagctaatt ggaatgtctg
     1501 gaatatttac tctggccacc ataggacttt ttctaaattc tacaagtttt aaaccaggag
     1561 ttgaagcatt tctcctcgaa ttctggaact gcctgtcctt tattggtttc cttatggtgt
     1621 tcactttcat tggacttcta atccctgcac acacatattt atatatatca ttttctgatg
     1681 tgtattactc attaaatatc tacttcacgc tgattgtttt aaggcttctg gtctttctgc
     1741 taatgagccc cattttgtct cgacttggtc acgggttcag ctggcgctgg gcgttcatca
     1801 tggtctggag tgaaatgaaa ggaacaccga acataaatat ggcccttctg cttgcctact
     1861 cggacgtttc tcttggttcc gagagggaaa gatctcaaat attattccat ggcgtgtcag
     1921 tatgtgtaat caccctgatt gtcaatagat ttattttgcc aatggcagta attaaactag
     1981 gtcttcgtga tgtcacatca acaaaatata aatcggttta ttatacattc cagcactttc
     2041 aagagctaac caaatccaca gccatggcac tcaaatttga caaagatctt gctaacgctg
     2101 actggaacat ggttgacaag gcgattatac ttcaaaatcc atatgcttta aaccaagaag
     2161 aaacaacgga acatcagaag gtgaaatgtc ctgattgcaa caaggaaata gatgagaccc
     2221 ttaacattga agccatggag ttggccaaca ggcgtctcct gtcagcgcaa atagcaagct
     2281 accaacgaca gtacaggaat gagattctgt cccagagtgc aatgcaagtg ttggtaggcg
     2341 cggccggaag ctttggtgag aagaagggag aatatatgag tcctgagaac ataaagaatt
     2401 attcagaaag caaaaaactc ctctcctttc ttagaaaatt actactcaac tgggtatata
     2461 atactaaaaa agataaaggg gttccatcaa gatacatgtt tcttcatgca tgccatagca
     2521 tagtcttcac aaatgaattt gaatacactg gatacatcgc tgtattaatg aacacatatc
     2581 cgatgataat ctgttggatt tcccgactaa aagacatcta tcaatatgag ataaaatgtg
     2641 ctaactacta ttttcttaca ttttatattc tagaggctct acttaaggtg gcagcaatga
     2701 ggaaggaatt tttttcacac acctggctcc tgtttgagct cgggattacc ttggtcggca
     2761 tcctagatat aatacttatc gaaacagact ccattagtta caaatttgac ttaactgaga
     2821 ctgtggtctt catgaacgtg gttcgactcc ttcgtatact gcgcatcttg aagcttataa
     2881 caccaaaatt gctgcaagta atagacaaaa ggatgagcca gcagatatcc ttccggtatg
     2941 ctatactaaa aggctacgtc caaggggaaa tggatgtact gaatataatt gatcagattg
     3001 caagttccaa acaggctaaa cagatattgt taaagcgagt aataaggaat atggatcatg
     3061 ctatgaaaga gctgggctac ctagagtatg atcacccaga aatcgctgtc actatgaaaa
     3121 ccaaggagga ggttaatgtg atgctcaata tggccagaga aattgtcaag gctttcaggt
     3181 ccaaaggaat tatacataag gtggaaggcg ctgagatcaa caagttaatc atggccaaaa
     3241 agaaacaagt gcttgagctg cagtctgtta tccagccact taatgttgaa gaagccccat
     3301 actatatccc atggctcagt gaagatcctg aagccataag ctttattcag gaaaaagcaa
     3361 aagttgtgac atttgactgc ggaaataaca tatttgagga aggcgacgaa ccagaaggaa
     3421 tctatgtaat aatttcgggc atggtaaagc ttaaaaggtc aaagccacac ctggagatgg
     3481 atagagtgtc ctcagagtca gaggttgctc agactagaag ttatacactg cctcacacag
     3541 aatatctgct cagcggggaa ataataggag agttaaactg tttgactaaa gaacggatgc
     3601 aatattctgc cacctgcaaa actgttgtgg agacgtattt tattcccatt agccacttgt
     3661 atgaaggctt tgaaaaaaaa taccctaaca tgaaatataa aatgtggcaa aaaatcggac
     3721 ttgccattac tgcccaaaag atccgggaaa acttatcttt tgaggactgg aactacaaga
     3781 tgcagttgaa actctgcaat gtcttcgtaa gggacatacc caagaccaca aaaactgaca
     3841 tctatgatga aacggtaacc catgttgtcc tcatccatgg atctgcagaa gactgccagt
     3901 tgcgaaaaat ttataaggca cctttcctaa ttcccgtgac atgccatcag atacaaggct
     3961 tagaagagtt cacaaaagtc atgattattc aaacttccgt tgctgtgaga aaattcaggt
     4021 ggaatgtaaa aaagtacaac ccacctcgaa ggatttcaat gaaaccagat tctacagaat
     4081 cacttgaaac attaaatgaa agttctgaag atgatgagga taaaaaagag aatgaagaaa
     4141 atgaggaata tttggaagat attattgaca tctcaagtgt ctccaagaaa taacctggaa
     4201 agaaagttta gtcagtcgcc tgagcttctc accatggcaa tgaaaacata tatttatgga
     4261 gatagagaca agccaaagtt tatatgcctc ttgtgtgata atgtgaatta aagtaccttg
     4321 cactagtcaa
//
LOCUS       NM_001437759            4303 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 6, mRNA.
ACCESSION   NM_001437759 XM_063270502
VERSION     NM_001437759.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4303)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4303)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4303)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4303)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4303)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4303)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4303)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4303)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4303)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4303)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270502.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1976929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  81641872-81642273   c
            403-583             JAXUCZ010000011.1  81639358-81639538   c
            584-654             JAXUCZ010000011.1  81637098-81637168   c
            655-876             JAXUCZ010000011.1  81634588-81634809   c
            877-1029            JAXUCZ010000011.1  81633460-81633612   c
            1030-1307           JAXUCZ010000011.1  81632731-81633008   c
            1308-1434           JAXUCZ010000011.1  81632129-81632255   c
            1435-1581           JAXUCZ010000011.1  81631579-81631725   c
            1582-1676           JAXUCZ010000011.1  81631398-81631492   c
            1677-1871           JAXUCZ010000011.1  81627329-81627523   c
            1872-1963           JAXUCZ010000011.1  81625109-81625200   c
            1964-2008           JAXUCZ010000011.1  81624400-81624444   c
            2009-2403           JAXUCZ010000011.1  81623352-81623746   c
            2404-3267           JAXUCZ010000011.1  81622398-81623261   c
            3268-3363           JAXUCZ010000011.1  81622212-81622307   c
            3364-3491           JAXUCZ010000011.1  81621930-81622057   c
            3492-4303           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4303
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             325..3498
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 6 is encoded by transcript variant 6;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 6"
                     /protein_id="NP_001424688.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRL
                     LEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH
                     RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLE
                     SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL
                     KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
                     YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEG
                     RAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCW
                     GFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRMKREPPPRPPQPAIFTHKPTYD
                     PVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKAGRSSGGEVTLIDFGEEP
                     VAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAY
                     DDVAQDEDDFEAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTG
                     QLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPR
                     EPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPR
                     AGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPP
                     STPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEA
                     ARPADKVQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHK
                     VLEMFDWNLEQAGCHLLGSCGPAHHKR"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <1822..3213
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1822..3213
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2719..2895
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2719..2895
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3256..3387
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3256..3387
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3346..3465
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3346..3465
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            403..583
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..654
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..876
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1029
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1307
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1434
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1581
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1676
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1871
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1963
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2008
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2403
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..3267
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3363
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3491
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..4303
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcaag caggcggtgg ggggaagctg gggagtagga ccagagctgt gagcactgca
       61 ctggagacag gacagaggac ccagcctgtg accagctgtg gaaacccagc caggcttgca
      121 ggggagccaa gccaccactc cattcttctt ccctgtttcc tacttctgtg tgggatctga
      181 gggatttcta ggacctgttc cccctactct ctgggcagac catagaactc agaagctggg
      241 gcccttgcct gcccacttta gaacgaggcc atagctcctg tgacttaggg gcttcagctt
      301 gtggaggggc ttcagcttgt ggagatgcca gcagcccgtc gatttcctgg ccttgagctc
      361 tccttccctc tcctggccag actgcggcga cgactgtata caaggctggg gagcagcagc
      421 atgcagccgg aggagggaac aggctggctg ctggagctgc tgtctgaggt gcagctacaa
      481 cagtatttcc tgaggctccg agatgacctc aacattaccc gcctgtctca ttttgagtat
      541 gtcaaaaacg aagacctgga aaagattggc atgggccggc ctggccagag gcggctatgg
      601 gaggctgtga agaggaggaa ggccatgtgc aaacgcaagt catggatgag caaggtgttc
      661 agtggaaagc ggcaggaggc tgagttccct tcccatcact ctcagagcac cttccggaag
      721 ccctccccca ccccaggggg cctggcaggg gaggggaccc tgcagagcct cacctgcctc
      781 attggggaga aagacctgcg cctgctggag aagctgggag atggctcctt tggcgtggtg
      841 cgcaggggtg aatgggatgc ccctgcaggg aagacggtga gtgtggccgt gaagtgcctg
      901 aaacctgatg tgctgagcca gcccgaggcc atggacgact tcatccggga ggtcaatgcc
      961 atgcattcgc tagaccaccg aaacctcatt cgcttgtacg gtgtggtgct cacaccaccc
     1021 atgaagatgg tgacagagct ggcccctctg ggatccttgt tggaccggct acgtaaacac
     1081 caaggtcatt tcctcttggg gacgctgagt cgctatgccg tgcaggtggc tgagggcatg
     1141 ggctacctgg agtccaagcg cttcattcac cgagacctgg ctgctcgaaa tctgcttttg
     1201 gccacccgtg acctggtcaa gattggggac tttggactga tgcgagctct gccccagaat
     1261 gatgaccact atgtcatgca agaacatcgc aaggtgccct ttgcctggtg tgcccctgag
     1321 agcctgaaga cacggacttt ctcccatgcc agtgacacct ggatgtttgg ggtcacactg
     1381 tgggagatgt ttacgtatgg ccaggagccc tggattggcc tcaatggcag ccagatcctg
     1441 cataagattg acaaggaagg ggagcgcctg ccccggcctg aggactgccc ccaagacatc
     1501 tacaatgtca tggtccagtg ctgggcccac aagccagagg acagacccac atttgtggcc
     1561 cttcgggact tcctgctgga ggctcagcct acagacatgc gggcccttca ggacttcgag
     1621 gagccggaca agctgcacat ccagatgaac gacgtcatta ctgtcattga gggaagggct
     1681 gagaactact ggtggcgtgg tcagaacaca cggacgctgt gtgtgggacc cttccctcga
     1741 aatgtggtga cctctgtggc tggcctgtca gcccaggaca tcagccagcc tctacagaat
     1801 agcttcattc acacagggca tggcgacagt gacccccgcc actgctgggg gttccctgac
     1861 aggatcgatg aactgtacct gggaaacccc atggaccccc ctgacctgct gagtgtggaa
     1921 ctgagcacct cgcgacccac ccagcattta ggacggatga aaagggagcc tccacctcgc
     1981 ccacctcagc ctgccatctt cactcacaag ccaacatatg accctgtgag tgaggaccca
     2041 gaccccctgt ccagcgactt caagagactt ggcctgagga agccagccct gccccgaggg
     2101 ctctggctgg caaagccctc agcccgggtg ccaggcacca aggcaggccg cagcagtggg
     2161 ggtgaggtca cactcatcga cttcggcgag gagcctgtag ccccaacccc acggccctgt
     2221 gcaccttcct tggcacagtt ggccatggat gcctgctccc tgctggacaa gacaccacca
     2281 cagagcccca cacgggcact gccacgacct ttacatccta cacctgtggt ggactgggac
     2341 gctcgcccgc tgcccccgcc ccctgcctac gatgatgtgg cccaagatga ggatgacttc
     2401 gaggcccagc tgccccctgc cctggaggat aacctgttcc tgccaccgca gggtggaggc
     2461 cagccaccca gctcagccca gactgcagag attttccagg cactgcagca ggagtgtatg
     2521 cggcagctac aggtccccac tggccagctg accccgtccc ctaccccagg aggtgatgac
     2581 aagccccagg tgccaccccg ggtacctatt ccccctcggc ccacacgtcc acgtgtggga
     2641 ctatctccag ctcccttagg tgaggaagag gcaagtcggt ggcctggacc ctcctcccct
     2701 ccccgagtgc ctccccggga acccctgtct cctcaagggt cgaggacccc aagcccccta
     2761 gtaccacctg gcagctcccc actaccgcat cggctctcga gctcacctgg aaagaccatg
     2821 cccaccaccc agagctttgc ctcagaccct aagtacgcca ctccacaagt gatccaggct
     2881 cctggcccac gggctggccc ctgcatcctg cccattgtcc gtgatggcag gaaggtcagc
     2941 agcacccact attacctgct gccagagcgc cctccctacc tcgagcgcta ccagcgcttc
     3001 ctgagggagg cccagagccc cgaggagccg gccgccctgc ccgttccccc actgctgccc
     3061 ccgcctagca ctccagcccc tgccgccccc actgccaccg tccgacctat gcctcaggct
     3121 gccccagacc caaaggccaa cttctccacc aataacagca acccaggggc gcagccacca
     3181 tccctgaggg ccagtgcacg gctgccgcag aggggctgcc caggggatgg gcaagaggct
     3241 gcccggccag cagacaaagt ccagatgctg caggccatgg tgcatggggt gaccacagag
     3301 gagtgccagg cggccctgag gagccacagc tggagtattc agagggctgc ccagtatctg
     3361 aaggtggagc agctctttgg gctgggtctt cggccacggg tggagtgcca caaagtgcta
     3421 gagatgttcg actggaacct agagcaagcc ggctgtcacc ttctggggtc ctgtggccct
     3481 gcccaccaca aacgctgatg gttgactgga gagcaatggt ctgccctaag agaacctctt
     3541 gaacctgtct gtgggacaag ggtggggaga tgccctgcct caggcctgga ggacccacaa
     3601 ctgcctgcgg ctcccagtgg acagtgagac ccaggcagca ggaggctggg agcctcacct
     3661 tgcccacctc gctcacccac ccagcgctgt tctgcacacc ttggttcagc cctcagtgcc
     3721 ccaaccaaga ggtgggaagt tccaagcctt gtgaaggcaa gacaggaagc tgcctggcag
     3781 gccctgtgtg tgacctgcct ttggccccag accaaggctg ggctggtggc tagagtgtgc
     3841 cccaggcttt ccctggggga ttagactgag aggaagccag gcttgacttg gacaagaagg
     3901 atgtgttggc cacacagaag ggtgggccag cacccaacag gccctcctca ggaccaggcc
     3961 cctttccagg gaacccctgt aggaatgtgg agtgttggac agaatgtgac ctgtggcttc
     4021 actgtgaact cgggcttggc tggtcttaga tcttgtagct gtaaacagcc tgaagtggct
     4081 cagaaacaga agaggcgcca ggatcttctc tggcagggac cagggcccca ggccccgggt
     4141 gtggagggag accccagcgg caccagtact tgtcctgttt gatgcctgtt cctcccctgt
     4201 gtccatttga tgtgttccca tcgcctctgt tgccaaagct gctgtcccag ccatggatat
     4261 ctgcttcttc cagagaaata aagtctgttt ctattttacg tca
//
LOCUS       NM_001008336            4225 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 1, mRNA.
ACCESSION   NM_001008336 XM_221379
VERSION     NM_001008336.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4225)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4225)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4225)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4225)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4225)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4225)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4225)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4225)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4225)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4225)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_001008336.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000011.1  81658796-81659074   c
            280-460             JAXUCZ010000011.1  81639358-81639538   c
            461-531             JAXUCZ010000011.1  81637098-81637168   c
            532-753             JAXUCZ010000011.1  81634588-81634809   c
            754-906             JAXUCZ010000011.1  81633460-81633612   c
            907-1184            JAXUCZ010000011.1  81632731-81633008   c
            1185-1311           JAXUCZ010000011.1  81632129-81632255   c
            1312-1458           JAXUCZ010000011.1  81631579-81631725   c
            1459-1553           JAXUCZ010000011.1  81631398-81631492   c
            1554-1748           JAXUCZ010000011.1  81627329-81627523   c
            1749-1840           JAXUCZ010000011.1  81625109-81625200   c
            1841-3189           JAXUCZ010000011.1  81622398-81623746   c
            3190-3285           JAXUCZ010000011.1  81622212-81622307   c
            3286-3413           JAXUCZ010000011.1  81621930-81622057   c
            3414-4225           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4225
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..279
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    193..195
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     exon            280..460
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3420
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 1"
                     /protein_id="NP_001008337.2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNE
                     DLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPS
                     PTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCL
                     KPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLR
                     KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA
                     LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL
                     NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD
                     MRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLS
                     AQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQ
                     HLGRMKKPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKAGRSSGG
                     EVTLIDFGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDW
                     DARPLPPPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGETNYAFVPEQAQLPPA
                     LEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVP
                     PRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQGSRTPSPLVPP
                     GSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSS
                     THYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQ
                     AAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAARPADKVQMLQAMVHGV
                     TTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLL
                     GSCGPAHHKR"
     misc_feature    298..627
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: SAM-like domain. /evidence=ECO:0000250"
     misc_feature    313..498
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    313..498
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    553..624
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    634..636
                     /gene="Tnk2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O54967; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    685..1458
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    685..1458
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(691..699,715..717,763..765,769..771,910..921,
                     931..933,1051..1053,1063..1068,1072..1074,1105..1107,
                     1162..1176,1201..1203,1303..1305)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(691..699,715..717,763..765,769..771,910..921,
                     931..933,1051..1053,1063..1068,1072..1074,1105..1107,
                     1162..1176,1201..1203,1303..1305)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(691..699,715..717,763..765,769..771,910..921,
                     931..933,1051..1053,1063..1068,1072..1074,1105..1107)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(691..699,715..717,763..765,769..771,910..921,
                     931..933,1051..1053,1063..1068,1072..1074,1105..1107)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1051..1053,1063..1065,1162..1176,1201..1203,
                     1303..1305)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1051..1053,1063..1065,1162..1176,1201..1203,
                     1303..1305)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1102..1134,1138..1182)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1102..1134,1138..1182)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1147..1149
                     /gene="Tnk2"
                     /note="Phosphotyrosine, by SRC and autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    1480..1629
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1480..1629
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1486..1488,1492..1494,1507..1509,1561..1563,
                     1567..1569,1612..1614,1618..1623)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    order(1486..1488,1492..1494,1507..1509,1561..1563,
                     1567..1569,1612..1614,1618..1623)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    1642..1839
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1642..1839
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1810..1878
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1849..1851
                     /gene="Tnk2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    <2035..3135
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2035..3135
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2164..2253
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Required for interaction with SRC.
                     /evidence=ECO:0000250"
     misc_feature    2191..2202
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Required for interaction with NEDD4.
                     /evidence=ECO:0000250"
     misc_feature    2461..2769
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2494..2925
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: EBD domain. /evidence=ECO:0000250"
     misc_feature    2641..2817
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2641..2817
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2776..2778
                     /gene="Tnk2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    2812..2814
                     /gene="Tnk2"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O54967; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); methylation site"
     misc_feature    2872..2874
                     /gene="Tnk2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    2911..2913
                     /gene="Tnk2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    2938..3168
                     /gene="Tnk2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2X5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2938..2940
                     /gene="Tnk2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07912; propagated from
                     UniProtKB/Swiss-Prot (Q5U2X5.1); phosphorylation site"
     misc_feature    3178..3309
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3178..3309
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3268..3387
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3268..3387
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            461..531
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..753
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..906
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1184
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1311
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1458
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1553
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1748
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1840
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..3189
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3285
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3413
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..4225
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccccagcg ggagagggat tccaagaggg acacagaacc cgcaggcgca gacgacgaag
       61 gaggtggtaa tctgcaagct gccttactgg catcggggtt gctctagtgc caagaggaat
      121 gcaggaagat gtaggggctt ggggagcaga agagcgctgt gaacctgacc tttggaagcc
      181 attgctggag ggtaggcagt ggcctgcaag atcctctctg ctacctcaag tctgagcatc
      241 cttgaagcag tgtctgcctg gggagagctg aaaactcaga ggctggggag cagcagcatg
      301 cagccggagg agggaacagg ctggctgctg gagctgctgt ctgaggtgca gctacaacag
      361 tatttcctga ggctccgaga tgacctcaac attacccgcc tgtctcattt tgagtatgtc
      421 aaaaacgaag acctggaaaa gattggcatg ggccggcctg gccagaggcg gctatgggag
      481 gctgtgaaga ggaggaaggc catgtgcaaa cgcaagtcat ggatgagcaa ggtgttcagt
      541 ggaaagcggc aggaggctga gttcccttcc catcactctc agagcacctt ccggaagccc
      601 tcccccaccc cagggggcct ggcaggggag gggaccctgc agagcctcac ctgcctcatt
      661 ggggagaaag acctgcgcct gctggagaag ctgggagatg gctcctttgg cgtggtgcgc
      721 aggggtgaat gggatgcccc tgcagggaag acggtgagtg tggccgtgaa gtgcctgaaa
      781 cctgatgtgc tgagccagcc cgaggccatg gacgacttca tccgggaggt caatgccatg
      841 cattcgctag accaccgaaa cctcattcgc ttgtacggtg tggtgctcac accacccatg
      901 aagatggtga cagagctggc ccctctggga tccttgttgg accggctacg taaacaccaa
      961 ggtcatttcc tcttggggac gctgagtcgc tatgccgtgc aggtggctga gggcatgggc
     1021 tacctggagt ccaagcgctt cattcaccga gacctggctg ctcgaaatct gcttttggcc
     1081 acccgtgacc tggtcaagat tggggacttt ggactgatgc gagctctgcc ccagaatgat
     1141 gaccactatg tcatgcaaga acatcgcaag gtgccctttg cctggtgtgc ccctgagagc
     1201 ctgaagacac ggactttctc ccatgccagt gacacctgga tgtttggggt cacactgtgg
     1261 gagatgttta cgtatggcca ggagccctgg attggcctca atggcagcca gatcctgcat
     1321 aagattgaca aggaagggga gcgcctgccc cggcctgagg actgccccca agacatctac
     1381 aatgtcatgg tccagtgctg ggcccacaag ccagaggaca gacccacatt tgtggccctt
     1441 cgggacttcc tgctggaggc tcagcctaca gacatgcggg cccttcagga cttcgaggag
     1501 ccggacaagc tgcacatcca gatgaacgac gtcattactg tcattgaggg aagggctgag
     1561 aactactggt ggcgtggtca gaacacacgg acgctgtgtg tgggaccctt ccctcgaaat
     1621 gtggtgacct ctgtggctgg cctgtcagcc caggacatca gccagcctct acagaatagc
     1681 ttcattcaca cagggcatgg cgacagtgac ccccgccact gctgggggtt ccctgacagg
     1741 atcgatgaac tgtacctggg aaaccccatg gacccccctg acctgctgag tgtggaactg
     1801 agcacctcgc gacccaccca gcatttagga cggatgaaaa agccaacata tgaccctgtg
     1861 agtgaggacc cagaccccct gtccagcgac ttcaagagac ttggcctgag gaagccagcc
     1921 ctgccccgag ggctctggct ggcaaagccc tcagcccggg tgccaggcac caaggcaggc
     1981 cgcagcagtg ggggtgaggt cacactcatc gacttcggcg aggagcctgt agccccaacc
     2041 ccacggccct gtgcaccttc cttggcacag ttggccatgg atgcctgctc cctgctggac
     2101 aagacaccac cacagagccc cacacgggca ctgccacgac ctttacatcc tacacctgtg
     2161 gtggactggg acgctcgccc gctgcccccg ccccctgcct acgatgatgt ggcccaagat
     2221 gaggatgact tcgaggtgtg ctctatcaac agcaccctag tgagtgcagg cctccctacc
     2281 gggcctagcc aaggcgagac caattatgcg tttgtacctg agcaggccca gctgccccct
     2341 gccctggagg ataacctgtt cctgccaccg cagggtggag gccagccacc cagctcagcc
     2401 cagactgcag agattttcca ggcactgcag caggagtgta tgcggcagct acaggtcccc
     2461 actggccagc tgaccccgtc ccctacccca ggaggtgatg acaagcccca ggtgccaccc
     2521 cgggtaccta ttccccctcg gcccacacgt ccacgtgtgg gactatctcc agctccctta
     2581 ggtgaggaag aggcaagtcg gtggcctgga ccctcctccc ctccccgagt gcctccccgg
     2641 gaacccctgt ctcctcaagg gtcgaggacc ccaagccccc tagtaccacc tggcagctcc
     2701 ccactaccgc atcggctctc gagctcacct ggaaagacca tgcccaccac ccagagcttt
     2761 gcctcagacc ctaagtacgc cactccacaa gtgatccagg ctcctggccc acgggctggc
     2821 ccctgcatcc tgcccattgt ccgtgatggc aggaaggtca gcagcaccca ctattacctg
     2881 ctgccagagc gccctcccta cctcgagcgc taccagcgct tcctgaggga ggcccagagc
     2941 cccgaggagc cggccgccct gcccgttccc ccactgctgc ccccgcctag cactccagcc
     3001 cctgccgccc ccactgccac cgtccgacct atgcctcagg ctgccccaga cccaaaggcc
     3061 aacttctcca ccaataacag caacccaggg gcgcagccac catccctgag ggccagtgca
     3121 cggctgccgc agaggggctg cccaggggat gggcaagagg ctgcccggcc agcagacaaa
     3181 gtccagatgc tgcaggccat ggtgcatggg gtgaccacag aggagtgcca ggcggccctg
     3241 aggagccaca gctggagtat tcagagggct gcccagtatc tgaaggtgga gcagctcttt
     3301 gggctgggtc ttcggccacg ggtggagtgc cacaaagtgc tagagatgtt cgactggaac
     3361 ctagagcaag ccggctgtca ccttctgggg tcctgtggcc ctgcccacca caaacgctga
     3421 tggttgactg gagagcaatg gtctgcccta agagaacctc ttgaacctgt ctgtgggaca
     3481 agggtgggga gatgccctgc ctcaggcctg gaggacccac aactgcctgc ggctcccagt
     3541 ggacagtgag acccaggcag caggaggctg ggagcctcac cttgcccacc tcgctcaccc
     3601 acccagcgct gttctgcaca ccttggttca gccctcagtg ccccaaccaa gaggtgggaa
     3661 gttccaagcc ttgtgaaggc aagacaggaa gctgcctggc aggccctgtg tgtgacctgc
     3721 ctttggcccc agaccaaggc tgggctggtg gctagagtgt gccccaggct ttccctgggg
     3781 gattagactg agaggaagcc aggcttgact tggacaagaa ggatgtgttg gccacacaga
     3841 agggtgggcc agcacccaac aggccctcct caggaccagg cccctttcca gggaacccct
     3901 gtaggaatgt ggagtgttgg acagaatgtg acctgtggct tcactgtgaa ctcgggcttg
     3961 gctggtctta gatcttgtag ctgtaaacag cctgaagtgg ctcagaaaca gaagaggcgc
     4021 caggatcttc tctggcaggg accagggccc caggccccgg gtgtggaggg agaccccagc
     4081 ggcaccagta cttgtcctgt ttgatgcctg ttcctcccct gtgtccattt gatgtgttcc
     4141 catcgcctct gttgccaaag ctgctgtccc agccatggat atctgcttct tccagagaaa
     4201 taaagtctgt ttctatttta cgtca
//
LOCUS       NM_001437689            4981 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 9,
            mRNA.
ACCESSION   NM_001437689 XM_039087895
VERSION     NM_001437689.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4981)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4981)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4981)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4981)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4981)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4981)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4981)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4981)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4981)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4981)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087895.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.30240.1,
                                           SRR26643292.46638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-431             JAXUCZ010000011.1  98105694-98105740
            432-503             JAXUCZ010000011.1  98106090-98106161
            504-590             JAXUCZ010000011.1  98108322-98108408
            591-753             JAXUCZ010000011.1  98109928-98110090
            754-874             JAXUCZ010000011.1  98113029-98113149
            875-1006            JAXUCZ010000011.1  98115531-98115662
            1007-1213           JAXUCZ010000011.1  98117537-98117743
            1214-1334           JAXUCZ010000011.1  98123938-98124058
            1335-1490           JAXUCZ010000011.1  98124251-98124406
            1491-1580           JAXUCZ010000011.1  98124558-98124647
            1581-1673           JAXUCZ010000011.1  98126328-98126420
            1674-1730           JAXUCZ010000011.1  98128415-98128471
            1731-1808           JAXUCZ010000011.1  98129086-98129163
            1809-2003           JAXUCZ010000011.1  98131039-98131233
            2004-2113           JAXUCZ010000011.1  98131384-98131493
            2114-2273           JAXUCZ010000011.1  98133415-98133574
            2274-4981           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4981
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2330
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 9 is encoded by transcript variant 9;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 9"
                     /protein_id="NP_001424618.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYT
                     DFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPK
                     DIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLD
                     LMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSL
                     ANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLL
                     QLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDI
                     LTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYS
                     TQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLM
                     NNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKVASAGGGI
                     GDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVP
                     VPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELV
                     GQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1040
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1040
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,570..572,
                     780..782,786..791,867..881,888..890)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,570..572,
                     780..782,786..791,867..881,888..890)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,582..584,621..623,696..698,702..704,
                     708..719,723..728,789..791,795..806,876..884)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,582..584,621..623,696..698,702..704,
                     708..719,723..728,789..791,795..806,876..884)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    570..581
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    570..581
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(576..581,669..674)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(576..581,669..674)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    777..788
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    777..788
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    807..1664
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    807..1664
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    867..875
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    867..875
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2037..2309
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2037..2309
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..431
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..503
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..590
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..753
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1006
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1213
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1334
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1490
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1580
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1673
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1730
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1808
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2003
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2113
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2273
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..4981
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggagttg aagcagaaga atggggtaaa tttcttcaca
      421 ccaaaaacaa gctttacaca gattttgatg aaattcgaca agaaattgaa aatgaaactg
      481 aaagaatttc aggaaataat aagggagtaa gccctgagcc aatccatctc aaggttttct
      541 cgcccaacgt tgtcaacctg acgcttgtgg atttaccagg aatgaccaaa gtacctgtag
      601 gtgatcagcc caaggatatt gagcttcaaa tcagagaact tattcttcgg ttcatcagta
      661 atcccaattc cattatcctt gctgtcactg ctgcaaatac agatatggca acgtcagagg
      721 cacttaagat ttccagagag gtagatccag atgggcgcag aactctagct gtaatcacca
      781 agcttgatct catggatgcg ggtactgatg ccatggatgt attgatggga agggttattc
      841 cagtcaagct tggaataatt ggagtagtta acaggagcca actggacatt aacaataaga
      901 agagtgtaac tgattcaatc cgtgatgagt atgcttttct tcaaaagaag tacccatctc
      961 tggccaacag aaatggaaca aagtatcttg ctaggactct gaataggtta cttatgcatc
     1021 atatcagaga ctgtttacca gagctgaaaa caagaataaa tgtcttagct gctcagtatc
     1081 agtctcttct aaatagctat ggtgagcccg tggatgataa aagtgctact ttactccagc
     1141 tcattaccaa gtttgccaca gagtattgta acactattga aggaacggca aagtacattg
     1201 aaacttctga gctatgtggt ggtgctagga tttgttatat tttccatgag acttttgggc
     1261 gaaccttaga atctgttgat ccactaggtg gccttaacac tattgacatc ttgaccgcca
     1321 ttagaaatgc tactggcccc cgtccagctt tatttgtgcc tgaagtttca tttgagttac
     1381 tggtcaaacg tcagattaag cgtctagagg agcccagcct ccgctgtgtg gagctggtcc
     1441 acgaggaaat gcagaggatc attcagcact gtagcaacta cagcacacag gaactgttac
     1501 ggttccctaa actccatgat gccatagttg aagtagtgac ttgtcttctt cgtaaaaggt
     1561 tgcccgtgac aaatgaaatg gtacataact tagtggcaat tgagctagca tatatcaaca
     1621 caaaacaccc cgactttgct gatgcctgtg ggctaatgaa caataacata gaggaacaaa
     1681 gaagaaacag actagcaaga gaactacctt ccgctgtatc gcgagacaag tcttctaaag
     1741 ttccaagtgc tttggcacct gcctcccagg agccctcccc tgccgcttct gccgaggctg
     1801 atggcaaggt tgcatctgca ggtggtggaa ttggagatgg tggtcgaatt ggagatggtg
     1861 gtcaggaacc gacaacaggc aactggagag gaatgctgaa aacttcaaaa gctgaagaat
     1921 tacttgctga agaaaaatca aaaccaattc caattatgcc agcaagtcca caaaaaggcc
     1981 atgctgtcaa tttgctagat gtgccagttc cagttgcacg aaaactgtct gcccgagaac
     2041 agcgagattg tgaggttatt gaaagactca tcaaatcata ttttctaatt gtcagaaaga
     2101 atattcaaga cagcgtccca aaggcagtaa tgcatttttt ggttaatcat gtgaaagata
     2161 ctcttcagag tgaattagta gggcagctgt ataagtcatc cttattagat gaccttctga
     2221 ctgaatccga ggacatggca cagcgaagaa aagaagcggc tgacatgctg aaggcattac
     2281 aaggagccag tcaaattatt gctgaaatcc gagagactca tctttggtga acagaactgt
     2341 ttggtcttct acactttgct gacttgaacc tactagctac tgcctacctg agtagaaatt
     2401 tatttatgga cttttgtgta tcgcagtgta tgaatttgct tgtgtgaaga ctggctataa
     2461 gctgaaaagt atattattca ttacaagaca aatcacatgt ttaattcaca tttttcaagt
     2521 ttcctatgat gtatatcaag tctgtccgtt tcagtcaaac ttacaagaac aattgatgtt
     2581 ctagttgtac aaagcagttt gcctgtgcat atgatgacct gcgtaacctt tttttagtct
     2641 taaagctgca gccgtagtcc tcaaagagga agctccagga catttcatga ctataatgca
     2701 tgcactattt atatagactg acctggcttc aaaaggtgga gcctggcgag ttcctcacat
     2761 aatcaatgta tccacctatc cttcattttt atagtcttaa aaaacaaaca aaattctgaa
     2821 acttctgcag ttttaggaaa aatataagat ctgaaagact cataaagatg taggaacaga
     2881 ctgtgtaatt aatggctcct gagtctatac tgccctaatg ttagaaagta aaatatgctt
     2941 tgattcaaaa taagcctgaa aatataaatt gacttcctgc attaaaaata actattagga
     3001 actttcttag taacaataac tggtcctgtt agtttctaaa tgactcagtg acaacctaaa
     3061 tttccctaat ttacaagtac atcgattgca gtccagatgc accttagggt ggggcgctga
     3121 ctctgggctc cgagactcag ttatgtgaga cctaaaagtc tactctgtat ccactggtaa
     3181 tgctacttta tagttccaca ccaacagaat acatttgtca aagaaaaata cctggacata
     3241 cacatacacc taaaagctta tggactacta aactgtattc aggggttgag gatttacaac
     3301 ctattttgtg aaaactgcct gtgcaattca atttctgacc tagctgggca gtggtggtgc
     3361 acacctttaa tcccagcttt tgggaggcag aggcaggtgg atctctgagt tcaaggccag
     3421 cctggtctac agagttgagt tccaagacaa ccagaactac acagagaaac cctgtcttga
     3481 acccccctcc ccccaaaaaa ttgaaaccta aatagaaatc tttgatgtat ctagttttct
     3541 ctgaccaaat gatacatttg tgttataaat actaaaattc ttttcaggtc aggcatctta
     3601 tgaaatacta ttagcaagga aaacaagaac atgttatctt tagtttagat gcccattgaa
     3661 ccatctcaaa aacaaaggca gtctgataac agtaccagct tgacagtgag tatacactgc
     3721 ctaaatgtgt tagcatactt aagaaaaata tcctgttatc taactattag gtatccatgg
     3781 tttatttttt aagagagatg accaccactg tagccttttg aatttgtaaa gagaaagaat
     3841 gcacctttat ccaacatttc aaatagattt taaaaggaag atgttagctt taaaaacgtg
     3901 ctatgataat gtacttgtta gcactacaca ctttgtacaa agaaaaacaa gcaagaaagg
     3961 tagggaaatg aaagcttcct ttgtgtactt ttacactaag ctgtgttctg aaacatggag
     4021 ataatttata agaccactgt atgttctatg taaataaaaa tgctggtgtg aaatggcatt
     4081 acggtttgcc agtaagtgaa ttcttcctga cttgccgtaa gagagaggtt taaataggtg
     4141 catctttgaa atatctgaat ctacttcata atggaacgat ttaaattgta ctgcaccaaa
     4201 agttttatgc cattttttta attagataat caccaccaag gccttgttac atctttgtgt
     4261 ctacagatga agacagaaac ttcttccaag taatccaagg atgaatgctg agaacatgaa
     4321 ctttgctgca agacgtctag aagctgatcc acagtttatg tttcacccct atgtacattg
     4381 gggtggtgct atcttgattt ttacagaaac tgtttttgag aattagcttg ccttgtgtat
     4441 acaaacctga actagtttga cttcaaaact tcctgtatct tttctgttct tactgactgc
     4501 atacttgatg agatactttt tgtttctttg gtttcttaaa atatctgcta taggaaccca
     4561 ctggcaaaaa taggcagtta tcagtaaatt attgaaacac agaacaagga agtggaaaac
     4621 tgaactataa atgaagtctg gtactgattg atgttttgtt ttaagaaaaa actattttgt
     4681 actacagttt ctattgggaa ccactgccat atctaactcc tttttaagaa ttctgtttgc
     4741 ttggcagcat caatcagaag tttaactttg taacagattt ctcacatcta aacagacatt
     4801 agaagcttgg ccagtttgta cagctatgta acacaactgc aatcaggtgc ttaccttacc
     4861 tcctgtgtta actttataca gtcatttcca ctgcaccact tcttcagacc aaggagcaag
     4921 aaagatcatt cttgcataaa gaaatgaact ataattaaat atcactttat tttgaaatgc
     4981 a
//
LOCUS       NM_001109588            1102 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family A, member 3 (Bpifa3),
            transcript variant 1, mRNA.
ACCESSION   NM_001109588 XM_001074347
VERSION     NM_001109588.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced NM_001109588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1054069.1,
                                           SRR26360181.2751518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000003.1  163069924-163070251
            329-479             JAXUCZ010000003.1  163073784-163073934
            480-587             JAXUCZ010000003.1  163075743-163075850
            588-737             JAXUCZ010000003.1  163077544-163077693
            738-822             JAXUCZ010000003.1  163078635-163078719
            823-886             JAXUCZ010000003.1  163079081-163079144
            887-1102            JAXUCZ010000003.1  163079641-163079856
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1102
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI fold containing family A, member 3"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
     exon            1..328
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="upstream in-frame stop codon"
     CDS             202..900
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="BPI fold-containing family A member 3 isoform 1
                     precursor"
                     /protein_id="NP_001103058.1"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
                     /translation="MHLLWRFLVLLLGLLALPSALPKQPWPGLTKAHKDGRSTLARII
                     AQGLLKHNAEGRIQSMRLLDRLNVSGTVAPGMVSWLISGMNFQQQQEISINITNVQLD
                     CGGIQMAFPKEWFSANITLEFDIEFKLPFNSNILKTHAQMGLAAESWLEKDEFGRRKL
                     VTGRCQMEPSSDSASMTTEAASPKMKNFLHNLRESLGKVIPNLVESQVCPLIGEILRQ
                     LDVKLLKGLVGGCS"
     sig_peptide     202..261
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    340..858
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     misc_feature    340..858
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     exon            329..479
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..587
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..737
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..822
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..886
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1102
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccaat gtgagctagc cctgggagca gctgccagag ccatttgtac cacctcccac
       61 agcatgctgg gggcagccgt gcagccacct gccggaagac agctgtaagc ccatcgatct
      121 gggtggccat actcacagcc aactgcctgg gccctgctgg accattactg acacctgcag
      181 gttcgggtgc cagcacttga gatgcaccta ctctggaggt tcctggtcct cctcctggga
      241 ttactagcct tgccctcagc cctgcccaag cagccttggc ctggactgac caaggcccac
      301 aaggatggcc ggtccaccct agcgagaatt attgcacagg gcctcctgaa gcacaatgca
      361 gaaggacgaa tccagagcat gcgtcttctg gaccgtctga acgtctcagg gacagtggcc
      421 ccagggatgg tgagctggct tattagtggc atgaacttcc agcagcagca agaaatcagt
      481 atcaacatta ccaatgtgca gctggactgt ggcgggatcc agatggcttt ccccaaagag
      541 tggttctccg caaacatcac acttgaattt gacattgaat tcaaactgcc cttcaattcg
      601 aatatcctca aaacccatgc ccagatgggc ctcgctgcag agtcctggct ggagaaagat
      661 gagttcggac ggaggaagct ggtgacaggc aggtgccaaa tggagcccag cagtgacagt
      721 gcatccatga ccactgaggc agcctcaccc aagatgaaga attttctcca caacctcaga
      781 gaaagcctgg ggaaagttat cccgaatttg gtagaaagtc aagtatgtcc tctgattggt
      841 gagatcctcc ggcagttgga tgtgaagcta ttgaaaggct tagtgggtgg ctgctcataa
      901 ccttggtcag ccctgaatca gtcaaatctc tgctatcagg ctcgaggggc ctcccattgc
      961 ctgccattgg tcaaaaggag gtacttctgg ttgagatctt acgtctctct cagtgtgtgg
     1021 cttctgctgt cccctggaaa aatgaccccc aggtcccaag acatcctgtc ctttccaaca
     1081 ataaactcta actctgaagg at
//
LOCUS       NM_001437703            5976 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus lipin 2 (Lpin2), transcript variant 2, mRNA.
ACCESSION   NM_001437703 XM_039083795
VERSION     NM_001437703.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5976)
  AUTHORS   Kok,B.P.C., Dyck,J.R.B., Harris,T.E. and Brindley,D.N.
  TITLE     Differential regulation of the expressions of the PGC-1alpha splice
            variants, lipins, and PPARalpha in heart compared to liver
  JOURNAL   J Lipid Res 54 (6), 1662-1677 (2013)
   PUBMED   23505321
  REMARK    GeneRIF: novel differences in the regulation of lipins 1,2,3,
            PPARalpha, and PGC-1alpha splice variants during fasting in heart
            versus liver, even though the ultimate outcome in both tissues is
            to increase FA turnover and oxidation.
REFERENCE   2  (bases 1 to 5976)
  AUTHORS   Donkor,J., Zhang,P., Wong,S., O'Loughlin,L., Dewald,J., Kok,B.P.,
            Brindley,D.N. and Reue,K.
  TITLE     A conserved serine residue is required for the phosphatidate
            phosphatase activity but not the transcriptional coactivator
            functions of lipin-1 and lipin-2
  JOURNAL   J Biol Chem 284 (43), 29968-29978 (2009)
   PUBMED   19717560
REFERENCE   3  (bases 1 to 5976)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   4  (bases 1 to 5976)
  AUTHORS   Donkor,J., Sariahmetoglu,M., Dewald,J., Brindley,D.N. and Reue,K.
  TITLE     Three mammalian lipins act as phosphatidate phosphatases with
            distinct tissue expression patterns
  JOURNAL   J Biol Chem 282 (6), 3450-3457 (2007)
   PUBMED   17158099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039083795.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.12723.1,
                                           SRR26643288.39184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000009.1  118529936-118530127
            193-267             JAXUCZ010000009.1  118546175-118546249
            268-468             JAXUCZ010000009.1  118566588-118566788
            469-564             JAXUCZ010000009.1  118574295-118574390
            565-866             JAXUCZ010000009.1  118577183-118577484
            867-974             JAXUCZ010000009.1  118583094-118583201
            975-1098            JAXUCZ010000009.1  118584036-118584159
            1099-1438           JAXUCZ010000009.1  118584979-118585318
            1439-1538           JAXUCZ010000009.1  118587525-118587624
            1539-1726           JAXUCZ010000009.1  118591807-118591994
            1727-1820           JAXUCZ010000009.1  118593072-118593165
            1821-1890           JAXUCZ010000009.1  118593540-118593609
            1891-1980           JAXUCZ010000009.1  118595824-118595913
            1981-2063           JAXUCZ010000009.1  118596663-118596745
            2064-2208           JAXUCZ010000009.1  118597611-118597755
            2209-2357           JAXUCZ010000009.1  118598265-118598413
            2358-2444           JAXUCZ010000009.1  118598933-118599019
            2445-2597           JAXUCZ010000009.1  118599579-118599731
            2598-2712           JAXUCZ010000009.1  118600067-118600181
            2713-2816           JAXUCZ010000009.1  118601244-118601347
            2817-5976           JAXUCZ010000009.1  118601637-118604796
FEATURES             Location/Qualifiers
     source          1..5976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..5976
                     /gene="Lpin2"
                     /note="lipin 2"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
     exon            1..192
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Lpin2"
                     /note="upstream in-frame stop codon"
     exon            193..267
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..468
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2961
                     /gene="Lpin2"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN2"
                     /protein_id="NP_001424632.1"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
                     /translation="MNYVGQLAGQVLVTVKELYKGINQATLSGCIDVVVVRQQDGSYQ
                     CSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAY
                     LATSPIPTEDQFFKHIDPPLVKSSGNERPPQSSDVSHTLESEAVFTPSSVKKKKRRRK
                     KCKQDNRKEEQAASPVAEDVGDVAVSSDDEKRAQAARGSSNASLKEEDYKEPPPFHSG
                     DNYPLSDGDWSPLETSYPQTVCPKSDSELEVKPSESLLRSESHMEWTWGGFPESTKVS
                     KRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCK
                     QLSDAASTELPESPLEAPQISSTLDADPVPSPSAEAPSEPKPAAKVDSPTKRKGVHKR
                     SQHQGPDDIYLDDLKALEPEVAALYFPKSDTDPGSRQWPESDTFSGSQSPQSVGSAAA
                     DSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNL
                     VIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKKESMT
                     KQLPETKEGKSEVPPANDLPSGTEEPVSARPAENDTSSDEGSQELEETIKVDPISMET
                     LSHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDK
                     VIISDIDGTITKSDALGQILPQLGKDWTHQGIARLYHSINENGYKFLYCSARAIGMAD
                     MTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAP
                     SRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVE
                     HVFPLLNKEQNSAFPCPEFSSFCYWRDPIPDVDLDDLA"
     misc_feature    277..597
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    277..597
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    <1252..1725
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1252..1725
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1675..1953
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    1675..1953
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    2179..2856
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    2179..2856
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    2893..>2949
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     misc_feature    2893..>2949
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     exon            469..564
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..866
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..974
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1098
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1438
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1538
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1726
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1820
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1890
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1980
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2063
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2208
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2357
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2444
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2597
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2712
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2816
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..5976
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtctacc gccagcctgg ccgccgccgc cgccgccgcc gccgccgtgt cccattcatg
       61 aggccccgcg ggctccgctg tggcccgcgg ctcctgaggc ggcggccccg ccccttgctc
      121 gcccgcttct cgccgcagcc cgcccgggcc gcccgacagt ctgccgagtg agagccgcgc
      181 gccgtgccgc agtttttcag gatccggagg atcttgaggt ggagttgttg tggaggacca
      241 gtcctctcag gagtccaggg gtgtgagtct caaaccatga attatgtggg ccagctggct
      301 gggcaggtgc ttgtcactgt gaaggaactc tacaagggca ttaaccaagc cactctatct
      361 gggtgcatcg atgtggtcgt ggtgcggcag caggatggct cctatcagtg ctcacctttt
      421 cacgtgcgct tcgggaagct gggtgtcctg aggtccaagg agaaggtgat tgacatagaa
      481 atcaatggca gtgctgtgga tcttcacatg aaattgggtg ataatggaga agccttcttt
      541 gtagaggaga ctgaagaaga atatgaaaaa ctgcctgctt atcttgccac ctcaccaatt
      601 ccaactgaag accagttctt taaacatatt gacccccctt tggtgaaatc aagtggaaat
      661 gaaaggccac cacagagttc agatgtttct cataccttgg aatcagaggc agttttcact
      721 ccgagttctg tgaaaaagaa gaaacggagg agaaagaagt gcaaacagga caataggaag
      781 gaggagcagg cggcttcccc tgttgcagaa gatgtaggcg atgtggctgt gagctctgat
      841 gatgagaaga gagcccaggc agcaagagga tcttcaaatg cttccttaaa ggaagaggac
      901 tataaggagc ctccgccttt ccattctggg gataactatc ccttatctga tggagattgg
      961 tctccattgg aaaccagtta cccacagaca gtgtgcccca agagtgactc ggagctggag
     1021 gtgaagccat ccgagagcct cctcagatct gagtcgcaca tggagtggac gtggggtggg
     1081 ttcccagagt ccaccaaggt cagcaaaaga gaaagatatg actatcatcc aaggacagct
     1141 acaattacac catcagaaaa cactcatttt agggtaattc ccagtgaaga cagcctcata
     1201 agagaagttg agaaggatgc tactgttgaa gatactacct gtaccatagt gaaacccaaa
     1261 cctcgagccc tgtgtaagca actgagtgat gcagcttcca ctgaacttcc tgaatcgcct
     1321 cttgaagcac ctcagatctc atctacatta gatgcagacc ctgttcccag cccatcagca
     1381 gaggctccct cagagcccaa accagctgct aaagtagact cacctacaaa gagaaaaggt
     1441 gttcacaaaa gaagccagca ccagggacct gatgacattt accttgatga cttaaaggct
     1501 cttgagcctg aagtggcagc tctctatttc cctaaaagtg acaccgatcc gggttctagg
     1561 cagtggcctg agtctgacac attctctggt tctcagtccc cacaatctgt gggaagtgca
     1621 gctgcagaca gtggcaccga atgcctctcg gattctgcca tggacttgcc tgatgtaact
     1681 ctctccctct gtggaggcct cagtgagaat ggagagattt ctaaagagaa gttcatggag
     1741 cacatcatca cgtaccacga gtttgcagag aaccctggcc ttatcgacaa cccgaacctt
     1801 gtgatccgga tctataaccg ttactacaac tgggcgttgg ctgctcccat gatccttagc
     1861 ttacaggtat ttcagaagag tctgcctaag gccacagtcg agtcctgggt taaagacaag
     1921 atgccgaaga aatctggccg gtggtggttt tggcgaaaga aagaaagcat gaccaaacag
     1981 ttgccggaga ccaaggaggg gaaatctgag gtccctccag caaatgacct gccttccggt
     2041 actgaggagc ccgtcagtgc cagacctgca gagaatgaca cttctagtga cgaggggtca
     2101 caggagttag aagaaaccat caaagttgac cccatctcga tggagacatt gagtcactgt
     2161 ggaacagcct catataagaa gtctctccga ctgtcctcgg accagatagc aaaactgaaa
     2221 ctccacgatg gccccaatga tgttgtattc agtatcacaa cccagtatca gggcacctgt
     2281 cggtgtgcgg gtaccattta cctgtggaac tggaatgaca aagtcatcat ttctgacatc
     2341 gatggaacaa taaccaagtc tgatgctttg ggacagattc tcccacagct gggtaaagac
     2401 tggactcatc agggcatagc taggctctac cattccatca atgagaatgg ttacaagttt
     2461 ctgtactgtt ctgcacgcgc catcggcatg gccgacatga cccgtggcta tttacactgg
     2521 gtcaatgaca agggcacaat cttgcctcga ggccccctga tgctgtcccc cagcagcttg
     2581 ttctctgcct tccacaggga agtgatagaa aagaaaccag agaagttcaa aattgagtgt
     2641 ctgaatgata ttaagaactt gtttgcccca tccaggcagc ccttctatgc tgcctttgga
     2701 aaccgtccca acgatgtcta tgcttacaca caagtcggag ttccagactg taggatattc
     2761 actgtgaatc caaagggtga attaatacaa gaaaggacca aaggaaacaa gtcatcgtat
     2821 cacaggctga gtgagcttgt ggaacacgtg ttcccacttc tcaataagga acagaattct
     2881 gccttcccat gcccagagtt cagttccttc tgctactgga gagacccaat ccctgacgtg
     2941 gacctggatg acctagcttg aaaaaggcct gtggcaaggt gggggcactg tcactcacct
     3001 cccagcaggg aaggtcactg gccctcttac agatgaagac ccaggagctg acaggaacct
     3061 gctttccaga acagggacag agtccccgaa gctggcactg ccaccttctt tcagcttcct
     3121 aagccaccac tcagcaccta gacagaggag taaggggcag tcagcctgca ttagaagcct
     3181 gtgctctgaa gcctgtgctc cattacttgt gggcctcaca tgcctcttgt ggagttgtgt
     3241 gctgtgcact ggtcagctgc atagtttaaa aaggaagaaa ccagaaactc aaaaagaaca
     3301 gaccagcaca tgactacaca aagtaaagag ttaaaatctc cactggtcag ttgggatcgt
     3361 ttctctctat aaacagggct ttctgcagag gtccagttag tgctgccagc tgtgtgtaca
     3421 tgtcctcctc cggacacctc cactcctgct cactgaacta ggacagctgc ttcatgtgcc
     3481 aggcaggcag cgccagcacc ttgagcccag ctgcgccagc gtgggctgta aagttggggg
     3541 aaggcagcct agcagcacca tctcctcgct gagaaggaag tcgtttaggt tgtcgttatg
     3601 acctagcaga agaacaggtg catatttcat gtctggagta acagtgaggc cttggtttaa
     3661 atcacaggag aggcagtggc tttcctcaga agtgtagggc agttgccttg ggccttggga
     3721 gtcctgttct ctgacactgt cactgcctta ggtggtcctt ggggcaggta tttcaggaca
     3781 ggatttttga aagtctgggc ttcagatttg ctaaggaaaa agcctttggc tggtggcatt
     3841 gaccagtcct ttgaactcca gccacataag aagtccatgg aggcgtggga gagagggcac
     3901 tgagtgcccg ttgagagcga gcaccgcggc aggagcccag cccacctgat tcacctgtca
     3961 gctctgaccc tcatgcagtt gatagtgggc tacccctgca cctcgctgca cctcgctggc
     4021 agcaccagac actggcctag ttaagtgctt gtcaatgttg gaacacacag caccagggag
     4081 agttttgtcc tcagatctgc agagccggga ccagctgggt gtggacagtc actgcagtgc
     4141 tcacatcgag aagtactgaa ggagggcgtt ccagagacct cagtggttca gtcacaacct
     4201 cccctgggaa gatggccgtg gcggcttctg agcagagggg gagccgccct taaagctgtt
     4261 ccaaccctgc atgccctgca gctggatggc tggcctgacc aggcttcagt ttgcttcact
     4321 caaaataacg ctcgcctaga gttggcttag aaaaggggtg gttattttcc agattggaga
     4381 gttgagtgtc cctgcctcat ttcagtattg cagttgaatg cagagaccat ggttgacaat
     4441 gtttaattaa agaaaaaaag gaccatgtga agcacagttc tcagtggcaa acctgaaggt
     4501 acatgctccc agagaagggg ccacacaggc ttccacagct gatgtttccc atacaattca
     4561 cttctccttc gtgagttatc tgtgttaggt agtagggaaa ctcagttacg tttatgtgaa
     4621 attcttgccg gttagtgaaa taagatccta ttaaagcagc cacgtgggat ttgatgccca
     4681 agccatcagt accttggtgg tgtagcacat cttcgcttta gggaagcaga attgtgtact
     4741 taacctgagc ttggtaggat ctcgtggtac agaatgtctt ttatgttttc tctcagacca
     4801 cttctgtttg tcctttaggg agctttttac ctagctagtc tgtttgcttt tcctgacaaa
     4861 ctcttttttt tttttttttt ttttttttgg acacatgggc ctcttcagaa ggtccagcat
     4921 aggctctggg tctcttggcc tgtgccgaga gggtggctgg tctttctgtc cgtctgtgtg
     4981 tctgttagcc cgacacttgt cactgcacat tgatcagtga atatttagga taatgaatgt
     5041 aactctttcc ttatttaaag gagtcttcct tgctgaaagt agatgattac tgttactgta
     5101 gtgttatgag tgttaggttt gtgctgaaaa tccattgcca tttgttacaa atgacatttg
     5161 ttctttctgt gaaagagaga tgcccttaag tgtgtttgca cacaaaccct tagatggctt
     5221 gttgcagtgt caccttgtct tcagtgacag gtgatgctga agagacacta tggcagacca
     5281 gccacccgtc cctccatcag tgttgcatca gtgactacgg ccccatgtct ttccagttca
     5341 gtctaatgtt agtgtctggt gtcgagtgtt ggcacttcca ctgctgtgga agtgatggct
     5401 gctctccctg tggaggttgt acatgtggac ctggagcaca cacacgtaac cgtatgatca
     5461 gtactgcatt tcctgtggtc tatctgcata gtcagttgga aaaagaaatg tgttggtgta
     5521 gtaacgtaaa aacaaaagct gctaaaacag cctagagtgg gtcaggacca cagctgagca
     5581 gcagggagcc tctgtcctgt gcagcccctg tccatggggc gggtccggcc ttctgtagtg
     5641 ctcttcaaag ccatcatccg agagaagaag cggttaaggt gacgagcgag tttatcacat
     5701 agccctggga aaccttgttt gagagcacgc tggggtttat gcaaaacttg aaggcagagg
     5761 aaagacttcc cttttaataa ttacactcag ctgatgaagg acttgattat tagagagcag
     5821 ccactgagca gctttcagtc gtcagtaatg aattgtaaac atcagtgcag taccttcaat
     5881 gtggtacaga agttgtcttc agatgaacgg ctcatgtttt ggtgcagtgt ttgatgttca
     5941 caaaaatgtt acaataataa actaacgtga actgag
//
LOCUS       NM_001437705            3098 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 3, mRNA.
ACCESSION   NM_001437705 XM_063270254
VERSION     NM_001437705.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.66346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000011.1  48251487-48251658   c
            173-390             JAXUCZ010000011.1  48198562-48198779   c
            391-542             JAXUCZ010000011.1  48179141-48179292   c
            543-746             JAXUCZ010000011.1  48168955-48169158   c
            747-827             JAXUCZ010000011.1  48168156-48168236   c
            828-899             JAXUCZ010000011.1  48166329-48166400   c
            900-956             JAXUCZ010000011.1  48158140-48158196   c
            957-1004            JAXUCZ010000011.1  48157502-48157549   c
            1005-3098           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3098
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..172
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     CDS             155..1525
                     /gene="Erg"
                     /note="isoform 3 is encoded by transcript variant 3; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 3"
                     /protein_id="NP_001424634.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGM
                     SYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPT
                     SSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSK
                     PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDL
                     PYMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPS
                     HLGTYY"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1013..1264
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1013..1264
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            173..390
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            391..542
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            543..746
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            828..899
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            900..956
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1004
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..3098
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatagaaacc tcttcctgcc attggctgac ttcatttccc agacttagca caatctcatc
       61 cgctctaaac aacctcatca aaactacttt ctggtcagag agaagcaata attattatta
      121 acatttatta acgatcaata aacttgattg cattatggcc agcactatta aggaggcctt
      181 gtcagttgtg agcgaggacc agtcactatt tgagtgtgcc tacggaacgc cacacctggc
      241 taagacagaa atgaccgcat cctcttccag tgactatggc cagacatcca agatgagtcc
      301 cagagtccca caacaggact ggctgtctca gcccccagcc agggtcacca tcaagatgga
      361 gtgcaaccct agccaggtga acggttccag gaactcacct gacgaatgca gtgtgaccaa
      421 aggtgggaag atggtgggca gccctgatac tgtgggaatg agctacggca gctacatgga
      481 ggagaagcac atgccgcccc ccaatatgac cacgaatgaa cgcagagtga tcgtccctgc
      541 agatcctact ctgtggagca cagaccatgt ccggcagtgg ctggagtggg cagtgaaaga
      601 atacggcctc ctagacgtgg acgtcttatt atttcagaat attgacggga aggagctgtg
      661 caagatgaca aaagatgact tccagaggct cactccgagc tacaatgccg acattcttct
      721 ctcacatctc cactacctca gagagactcc ccttccacat ctgacatccg acgacgttga
      781 taaggcttta caaaactctc cacggttaat gcatgctaga aacacagggg gtgcagcttt
      841 tattttcccc aatacttcag tatatcccga agccacgcag agaattacaa ctaggccagc
      901 tgcccagcca tctccctcca cagtgcccaa aactgaagac cagcgtcctc agttagatcc
      961 ttaccagatc ctgggaccca ccagtagtcg ccttgctaat ccaggtagtg gccagatcca
     1021 gctgtggcag ttcctgctag aactcctgtc tgacagctcc aactccaact gcatcacctg
     1081 ggaaggcacc aacggggagt tcaagatgac agacccggat gaggtggctc ggcgctgggg
     1141 ggagcggaag agcaagccca acatgaacta tgacaaactc agccgtgccc tccgctacta
     1201 ctacgacaaa aacatcatga ccaaggtgca tgggaagcgc tatgcctaca agtttgactt
     1261 ccacgggatt gcccaggccc tgcagcccca tccccccgag tcgtccctgt acaagtaccc
     1321 ctccgacctg ccgtacatgg gctcctatca cacccacccc cagaagatga actttgtggc
     1381 tccccaccct ccggccctcc cagtcacatc ttccagtttc tttgctaccc cgaacccata
     1441 ctggaattcg ccgactgggg gcatctaccc gaacactagg ctcccagcca gccatatgcc
     1501 ctctcacctg ggcacctact actagagacc agatagaggc ctttcccaac agtgcacaat
     1561 cgcctagcaa tcaccacaaa ctcagagaac acaaatcgaa agtgcctcct gaggaatgga
     1621 aacggttggc cagagctggg gaaggaagcc ggggaaagaa aaccaaagac tcacagggga
     1681 gggtgggcac cacccaagta ttactacaga aatagaagaa gctcaaaata tactgtacat
     1741 ggacatataa cctgtggtcc acccttgtca aagacattgt atgtagaaaa gcgtgaccga
     1801 gaagaacaac tgtccaagga agtggcctta agtagtgtac aaactgtaga gtgtgggacc
     1861 ttgcttgtac caggattcag tgagagcaat agaaccataa cagtcttggc ctagcacacc
     1921 atcacgtgtg atgacatttg aagggaaact acctgtgttt aaaaacagaa aaaaacatat
     1981 ccaaaccaaa taagaagagg aaaaaaaaaa aaagatggcg gcccctccac agaccacaat
     2041 ggctgtggat tttcttggct ggcatttgct gttttcattg aaatcaggtt cgttccattt
     2101 gatagggagc tgccagctct gtcaaactgt gaagatgacc cagcgtctca tcaccttttc
     2161 agtattacgg gaaatgtggg ccatgtggtg ggcggggaat gtatgtgcat gttgttgtga
     2221 gtatgtgatc atagaagaaa gactgaaacg gaggaagaga tagaggatca ggggttgggg
     2281 agggagttaa gggagaggag gaagtggaag aggaagagga ggagggagga ggagaaaggg
     2341 ggaggaagaa aaggaggaag aggagaaagg aggaggaaga aaaggagaaa atgaggaaga
     2401 gaaggaaaag aagaaaagaa gggggaggaa gaggagaagg aggaagagga agagaggaag
     2461 agaagcaagc tgctcaagcc accacagctg aatttaggac atcttgggac caaagagcat
     2521 gagtcaagat gtttgatgct gccagggttg taagaaagga cacagatttg tggaggactg
     2581 ggagcagtag tattcagaac caaaaatatg tctctttgtg aaaaggaaat cataactgga
     2641 attgtctgat atttaaaaaa ttcaggacct cagtattcaa tggaggcttt gtccttcaca
     2701 gggggcagtt gagaggtgac cttggtggct accatggtca gagaccacac aggcattgtg
     2761 ggtaggtggg ctccagtttt ccttaatgag tcgcgaacgc tgtgcgttcg tcagaacgaa
     2821 gtctacaagt caatggtttt tttcttttta tataataatt atataactta tgcatttata
     2881 cactacgagt tgacctcggc cagccaaaga caccacacac acacacacac acacacacac
     2941 acacacacac acacacacaa aagagacaat caaacatatg atgtggcctt gaattttaac
     3001 tctgtaatgc ttaatgttta caatatgaag ttactagttc ttagaatgca gaatgtatgt
     3061 taataaaaat gagcttggcc tctcatggcg aaccagaa
//
LOCUS       NM_001437760            4297 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 7, mRNA.
ACCESSION   NM_001437760 XM_063270503
VERSION     NM_001437760.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4297)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4297)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4297)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4297)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4297)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4297)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4297)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270503.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.45968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  81641872-81642273   c
            403-583             JAXUCZ010000011.1  81639358-81639538   c
            584-654             JAXUCZ010000011.1  81637098-81637168   c
            655-825             JAXUCZ010000011.1  81634588-81634758   c
            826-978             JAXUCZ010000011.1  81633460-81633612   c
            979-1256            JAXUCZ010000011.1  81632731-81633008   c
            1257-1383           JAXUCZ010000011.1  81632129-81632255   c
            1384-1530           JAXUCZ010000011.1  81631579-81631725   c
            1531-1625           JAXUCZ010000011.1  81631398-81631492   c
            1626-1820           JAXUCZ010000011.1  81627329-81627523   c
            1821-1912           JAXUCZ010000011.1  81625109-81625200   c
            1913-3261           JAXUCZ010000011.1  81622398-81623746   c
            3262-3357           JAXUCZ010000011.1  81622212-81622307   c
            3358-3485           JAXUCZ010000011.1  81621930-81622057   c
            3486-4297           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4297
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             325..3492
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 7 is encoded by transcript variant 7;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 7"
                     /protein_id="NP_001424689.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEW
                     DAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKM
                     VTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA
                     TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVT
                     LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT
                     FVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV
                     GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDP
                     PDLLSVELSTSRPTQHLGRMKKPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKP
                     SARVPGTKAGRSSGGEVTLIDFGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPT
                     RALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGE
                     TNYAFVPEQAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQL
                     TPSPTPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREP
                     LSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG
                     PCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPST
                     PAPAAPTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAAR
                     PADKVQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVL
                     EMFDWNLEQAGCHLLGSCGPAHHKR"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    757..1530
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    757..1530
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179,
                     1234..1248,1273..1275,1375..1377)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179,
                     1234..1248,1273..1275,1375..1377)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1123..1125,1135..1137,1234..1248,1273..1275,
                     1375..1377)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1123..1125,1135..1137,1234..1248,1273..1275,
                     1375..1377)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1206,1210..1254)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1206,1210..1254)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1552..1701
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1552..1701
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1558..1560,1564..1566,1579..1581,1633..1635,
                     1639..1641,1684..1686,1690..1695)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    order(1558..1560,1564..1566,1579..1581,1633..1635,
                     1639..1641,1684..1686,1690..1695)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    1714..1911
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1714..1911
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <2107..3207
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2107..3207
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2713..2889
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2713..2889
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3250..3381
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3250..3381
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3340..3459
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3340..3459
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            403..583
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..654
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..825
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..978
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1256
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1383
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1530
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1625
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1820
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1912
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..3261
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3357
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3485
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..4297
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcaag caggcggtgg ggggaagctg gggagtagga ccagagctgt gagcactgca
       61 ctggagacag gacagaggac ccagcctgtg accagctgtg gaaacccagc caggcttgca
      121 ggggagccaa gccaccactc cattcttctt ccctgtttcc tacttctgtg tgggatctga
      181 gggatttcta ggacctgttc cccctactct ctgggcagac catagaactc agaagctggg
      241 gcccttgcct gcccacttta gaacgaggcc atagctcctg tgacttaggg gcttcagctt
      301 gtggaggggc ttcagcttgt ggagatgcca gcagcccgtc gatttcctgg ccttgagctc
      361 tccttccctc tcctggccag actgcggcga cgactgtata caaggctggg gagcagcagc
      421 atgcagccgg aggagggaac aggctggctg ctggagctgc tgtctgaggt gcagctacaa
      481 cagtatttcc tgaggctccg agatgacctc aacattaccc gcctgtctca ttttgagtat
      541 gtcaaaaacg aagacctgga aaagattggc atgggccggc ctggccagag gcggctatgg
      601 gaggctgtga agaggaggaa ggccatgtgc aaacgcaagt catggatgag caagagcacc
      661 ttccggaagc cctcccccac cccagggggc ctggcagggg aggggaccct gcagagcctc
      721 acctgcctca ttggggagaa agacctgcgc ctgctggaga agctgggaga tggctccttt
      781 ggcgtggtgc gcaggggtga atgggatgcc cctgcaggga agacggtgag tgtggccgtg
      841 aagtgcctga aacctgatgt gctgagccag cccgaggcca tggacgactt catccgggag
      901 gtcaatgcca tgcattcgct agaccaccga aacctcattc gcttgtacgg tgtggtgctc
      961 acaccaccca tgaagatggt gacagagctg gcccctctgg gatccttgtt ggaccggcta
     1021 cgtaaacacc aaggtcattt cctcttgggg acgctgagtc gctatgccgt gcaggtggct
     1081 gagggcatgg gctacctgga gtccaagcgc ttcattcacc gagacctggc tgctcgaaat
     1141 ctgcttttgg ccacccgtga cctggtcaag attggggact ttggactgat gcgagctctg
     1201 ccccagaatg atgaccacta tgtcatgcaa gaacatcgca aggtgccctt tgcctggtgt
     1261 gcccctgaga gcctgaagac acggactttc tcccatgcca gtgacacctg gatgtttggg
     1321 gtcacactgt gggagatgtt tacgtatggc caggagccct ggattggcct caatggcagc
     1381 cagatcctgc ataagattga caaggaaggg gagcgcctgc cccggcctga ggactgcccc
     1441 caagacatct acaatgtcat ggtccagtgc tgggcccaca agccagagga cagacccaca
     1501 tttgtggccc ttcgggactt cctgctggag gctcagccta cagacatgcg ggcccttcag
     1561 gacttcgagg agccggacaa gctgcacatc cagatgaacg acgtcattac tgtcattgag
     1621 ggaagggctg agaactactg gtggcgtggt cagaacacac ggacgctgtg tgtgggaccc
     1681 ttccctcgaa atgtggtgac ctctgtggct ggcctgtcag cccaggacat cagccagcct
     1741 ctacagaata gcttcattca cacagggcat ggcgacagtg acccccgcca ctgctggggg
     1801 ttccctgaca ggatcgatga actgtacctg ggaaacccca tggacccccc tgacctgctg
     1861 agtgtggaac tgagcacctc gcgacccacc cagcatttag gacggatgaa aaagccaaca
     1921 tatgaccctg tgagtgagga cccagacccc ctgtccagcg acttcaagag acttggcctg
     1981 aggaagccag ccctgccccg agggctctgg ctggcaaagc cctcagcccg ggtgccaggc
     2041 accaaggcag gccgcagcag tgggggtgag gtcacactca tcgacttcgg cgaggagcct
     2101 gtagccccaa ccccacggcc ctgtgcacct tccttggcac agttggccat ggatgcctgc
     2161 tccctgctgg acaagacacc accacagagc cccacacggg cactgccacg acctttacat
     2221 cctacacctg tggtggactg ggacgctcgc ccgctgcccc cgccccctgc ctacgatgat
     2281 gtggcccaag atgaggatga cttcgaggtg tgctctatca acagcaccct agtgagtgca
     2341 ggcctcccta ccgggcctag ccaaggcgag accaattatg cgtttgtacc tgagcaggcc
     2401 cagctgcccc ctgccctgga ggataacctg ttcctgccac cgcagggtgg aggccagcca
     2461 cccagctcag cccagactgc agagattttc caggcactgc agcaggagtg tatgcggcag
     2521 ctacaggtcc ccactggcca gctgaccccg tcccctaccc caggaggtga tgacaagccc
     2581 caggtgccac cccgggtacc tattccccct cggcccacac gtccacgtgt gggactatct
     2641 ccagctccct taggtgagga agaggcaagt cggtggcctg gaccctcctc ccctccccga
     2701 gtgcctcccc gggaacccct gtctcctcaa gggtcgagga ccccaagccc cctagtacca
     2761 cctggcagct ccccactacc gcatcggctc tcgagctcac ctggaaagac catgcccacc
     2821 acccagagct ttgcctcaga ccctaagtac gccactccac aagtgatcca ggctcctggc
     2881 ccacgggctg gcccctgcat cctgcccatt gtccgtgatg gcaggaaggt cagcagcacc
     2941 cactattacc tgctgccaga gcgccctccc tacctcgagc gctaccagcg cttcctgagg
     3001 gaggcccaga gccccgagga gccggccgcc ctgcccgttc ccccactgct gcccccgcct
     3061 agcactccag cccctgccgc ccccactgcc accgtccgac ctatgcctca ggctgcccca
     3121 gacccaaagg ccaacttctc caccaataac agcaacccag gggcgcagcc accatccctg
     3181 agggccagtg cacggctgcc gcagaggggc tgcccagggg atgggcaaga ggctgcccgg
     3241 ccagcagaca aagtccagat gctgcaggcc atggtgcatg gggtgaccac agaggagtgc
     3301 caggcggccc tgaggagcca cagctggagt attcagaggg ctgcccagta tctgaaggtg
     3361 gagcagctct ttgggctggg tcttcggcca cgggtggagt gccacaaagt gctagagatg
     3421 ttcgactgga acctagagca agccggctgt caccttctgg ggtcctgtgg ccctgcccac
     3481 cacaaacgct gatggttgac tggagagcaa tggtctgccc taagagaacc tcttgaacct
     3541 gtctgtggga caagggtggg gagatgccct gcctcaggcc tggaggaccc acaactgcct
     3601 gcggctccca gtggacagtg agacccaggc agcaggaggc tgggagcctc accttgccca
     3661 cctcgctcac ccacccagcg ctgttctgca caccttggtt cagccctcag tgccccaacc
     3721 aagaggtggg aagttccaag ccttgtgaag gcaagacagg aagctgcctg gcaggccctg
     3781 tgtgtgacct gcctttggcc ccagaccaag gctgggctgg tggctagagt gtgccccagg
     3841 ctttccctgg gggattagac tgagaggaag ccaggcttga cttggacaag aaggatgtgt
     3901 tggccacaca gaagggtggg ccagcaccca acaggccctc ctcaggacca ggcccctttc
     3961 cagggaaccc ctgtaggaat gtggagtgtt ggacagaatg tgacctgtgg cttcactgtg
     4021 aactcgggct tggctggtct tagatcttgt agctgtaaac agcctgaagt ggctcagaaa
     4081 cagaagaggc gccaggatct tctctggcag ggaccagggc cccaggcccc gggtgtggag
     4141 ggagacccca gcggcaccag tacttgtcct gtttgatgcc tgttcctccc ctgtgtccat
     4201 ttgatgtgtt cccatcgcct ctgttgccaa agctgctgtc ccagccatgg atatctgctt
     4261 cttccagaga aataaagtct gtttctattt tacgtca
//
LOCUS       NM_138885              11003 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus golgin B1 (Golgb1), transcript variant 1, mRNA.
ACCESSION   NM_138885
VERSION     NM_138885.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11003)
  AUTHORS   Casey,C.A., Thomes,P., Manca,S. and Petrosyan,A.
  TITLE     Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver
            Cells
  JOURNAL   Biomolecules 8 (4), 150 (2018)
   PUBMED   30453527
  REMARK    GeneRIF: Ethanol-induced Golgi disassembly was associated with
            de-dimerization of the largest Golgi matrix protein giantin, along
            with impaired transport of selected hepatic proteins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11003)
  AUTHORS   Katayama,K., Kuriki,M., Kamiya,T., Tochigi,Y. and Suzuki,H.
  TITLE     Giantin is required for coordinated production of aggrecan, link
            protein and type XI collagen during chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 499 (3), 459-465 (2018)
   PUBMED   29577904
  REMARK    GeneRIF: giantin plays a pivotal role in coordinated production of
            aggrecan, link protein and type XI collagen in chondrocytes.
REFERENCE   3  (bases 1 to 11003)
  AUTHORS   Asante,D., Stevenson,N.L. and Stephens,D.J.
  TITLE     Subunit composition of the human cytoplasmic dynein-2 complex
  JOURNAL   J Cell Sci 127 (Pt 21), 4774-4787 (2014)
   PUBMED   25205765
REFERENCE   4  (bases 1 to 11003)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 11003)
  AUTHORS   Fusco,C., Micale,L., Egorov,M., Monti,M., D'Addetta,E.V.,
            Augello,B., Cozzolino,F., Calcagni,A., Fontana,A., Polishchuk,R.S.,
            Didelot,G., Reymond,A., Pucci,P. and Merla,G.
  TITLE     The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and
            promotes the sequestration and clearance of ubiquitinated proteins
            into the aggresome
  JOURNAL   PLoS One 7 (7), e40440 (2012)
   PUBMED   22792322
REFERENCE   6  (bases 1 to 11003)
  AUTHORS   Katayama,K., Sasaki,T., Goto,S., Ogasawara,K., Maru,H., Suzuki,K.
            and Suzuki,H.
  TITLE     Insertional mutation in the Golgb1 gene is associated with
            osteochondrodysplasia and systemic edema in the OCD rat
  JOURNAL   Bone 49 (5), 1027-1036 (2011)
   PUBMED   21851869
  REMARK    GeneRIF: concluded that mutation of the Golgb1 gene is responsible
            for the phenotypic characteristics including osteochondrodysplasia
            of ocd/ocd, and that giantin plays a pivotal role in multiple
            aspects of chondrogenesis
REFERENCE   7  (bases 1 to 11003)
  AUTHORS   Zhang,B., Zheng,C., Zhu,M., Tao,J., Vasievich,M.P., Baines,A.,
            Kim,J., Schekman,R., Kaufman,R.J. and Ginsburg,D.
  TITLE     Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
            accumulation of alpha1-antitrypsin
  JOURNAL   Blood 118 (12), 3384-3391 (2011)
   PUBMED   21795745
REFERENCE   8  (bases 1 to 11003)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 11003)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   10 (bases 1 to 11003)
  AUTHORS   Diella,F., Levi,G. and Callahan,R.
  TITLE     Characterization of the INT6 mammary tumor gene product
  JOURNAL   DNA Cell Biol 16 (7), 839-847 (1997)
   PUBMED   9260927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_138885.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25543.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000011.1  77405910-77406029   c
            121-312             JAXUCZ010000011.1  77395914-77396105   c
            313-407             JAXUCZ010000011.1  77394529-77394623   c
            408-560             JAXUCZ010000011.1  77393412-77393564   c
            561-710             JAXUCZ010000011.1  77393106-77393255   c
            711-839             JAXUCZ010000011.1  77391172-77391300   c
            840-965             JAXUCZ010000011.1  77388259-77388384   c
            966-1079            JAXUCZ010000011.1  77384776-77384889   c
            1080-1461           JAXUCZ010000011.1  77382442-77382823   c
            1462-1577           JAXUCZ010000011.1  77380722-77380837   c
            1578-1692           JAXUCZ010000011.1  77376673-77376787   c
            1693-1766           JAXUCZ010000011.1  77373742-77373815   c
            1767-6889           JAXUCZ010000011.1  77364402-77369524   c
            6890-8777           JAXUCZ010000011.1  77361629-77363516   c
            8778-8956           JAXUCZ010000011.1  77357257-77357435   c
            8957-9119           JAXUCZ010000011.1  77356198-77356360   c
            9120-9257           JAXUCZ010000011.1  77355886-77356023   c
            9258-9404           JAXUCZ010000011.1  77353582-77353728   c
            9405-9502           JAXUCZ010000011.1  77353246-77353343   c
            9503-9637           JAXUCZ010000011.1  77352612-77352746   c
            9638-9743           JAXUCZ010000011.1  77350034-77350139   c
            9744-11003          JAXUCZ010000011.1  77348569-77349828   c
FEATURES             Location/Qualifiers
     source          1..11003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..11003
                     /gene="Golgb1"
                     /note="golgin B1"
                     /db_xref="GeneID:192243"
                     /db_xref="RGD:708429"
     exon            1..120
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..312
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    243..245
                     /gene="Golgb1"
                     /note="upstream in-frame stop codon"
     exon            313..407
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..9878
                     /gene="Golgb1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Golgin subfamily B member 1; golgi autoantigen, golgin
                     subfamily b, macrogolgin 1; golgi-associated protein
                     GCP360; golgin B1, golgi integral membrane protein"
                     /codon_start=1
                     /product="golgin subfamily B member 1 isoform 1"
                     /protein_id="NP_620240.2"
                     /db_xref="GeneID:192243"
                     /db_xref="RGD:708429"
                     /translation="MLSRLSGLANNVLHELSGDYTGWTTMTSSEAELPQGSAMELNNS
                     TQKDVLDRLADAEKLVLELKDIISKQDAQLQQKDEALQEEKKGAESKIKKIKLHAKAK
                     ITSLNKQIEELKTQGGAASPPEVQAEELSKHDKSSTEEEMEVEKIKHELQEKEKLISN
                     LQAQLDQAQSEQASQLDKSSAEMEDFVLMRQKLQEKEELIGALQTQLSQTQAEQAAQK
                     LRVMQRKLEEHEEALLGRAQVVDLLQKELTSAEQRNQDLSQQLQLLEAEHSTLRNTME
                     AERQESKILMEKVELEMAERKEELYQLQGQLERAGQAQAELEMQYGTLQQRHETEMEE
                     KTACISLLQKNEQELQSACDALKEENSKLLQEQQEQAAKSAQALQQLEDELQQKSKEI
                     SQFVNKPNLEKHETSSQTSLPDVYNEGVQAVMEESVASLQKRVLELENEKGALLLSSL
                     ELEELRAENEKLCSRITLLEAQNRAGEADGMVCEVSTAGIALLNRSDSSTEESGQDVL
                     ENTFSQKHKELSVLLVEMKEAQEEIAFLKSQLQGKRPEGDYEVLDRKEVQMMESEGLP
                     SVTARDVLCAPRDKNSVPAVEGEQAGMRDQHGTLEAGPLNDTGMELNSPQPDGVDKSL
                     SAPHVCLCHQGELERLKTQVLELETSLHTAKETHEKNLSEKAKEISSLTQLTKEFKES
                     AEEARSTLTAVCEERDQLLYRVKELDVLGELRAQVRELETSLAEAEKQRGLDYESQRA
                     QHNLLTEQIHSLSIEAKSKDVKIETLQRELDGVQLQFSEQGTQIRSLQSQLQTKESEV
                     LEGAERMKDISKEMEELSQALSQKELEIAQMDQLLLEKKKDVETLQQTIQEKDQQVTE
                     LSFSMTEKMVQLNEEKFSLGVEIKTLKEQLSLLSRAEGAKKEQVEDSGAESSPKHGPH
                     ESSAQEPVCKDALQQELEWLRKESEQRKRKLQAALISRKELLQKVSKLEEELAKVREE
                     STKDSLRESEKRELEEDSKNKDDPEKYGTSEWRELEVSLRLTISEKEVELEGIRRDLK
                     EKAAAEEELQALVQRMTQDLQNKTKQIDLLQEEITENQATIQKFITGTMDAGDGDSAV
                     KETSVSSPPRAGGGEHWKPELEGKIVDLEKEKTQLQKKLQEALISRKAILKKAQEKEK
                     HLKEELKEQKDAYRHLQEQFDGQSKENENIAARLRQLQAKESTDQQLPGTGQQEPTHG
                     SEGLSLEGTEPASESDLHAAQPSHPGETATLQATVSVAQIQDQLKEIEVEKEELELKI
                     SSTTSELTKKSEEVLLLQEQINEQGLEIQNLKAASHEAKAHTEQLKQELESSQLKIAD
                     LEHLKTLQPELETLQKHVGQKEEEVSYLVGQLGEKEQTLTTVQTEMEEQERLIKALHT
                     QLEMQAKEHEERLKQVQVEICELKKQPKELEEESKAKQQLQRKLQAALISRKEALKEN
                     KSLQEQLSSARDAVEHLTKSLADVESQVSVQNQEKDALLGKLALLQEERDKLIVEMDK
                     SLLENQSLGGSCESLKLALGGLTEDKEKLMKELESVRCSKIAESTEWQEKHKELQKEY
                     EVLLQSYENVSNEAERIQHVVESVRQEKQEVYAKLRSAESDKREREKQLQDAEQEMEE
                     MKEKMRKFAKSKQQKILELEEENDRLRAEAQPVGGANESMEALLSSNASLKEELERIT
                     LEYKTLSKEFEALMAEKNTLSEETRNLKLQVEAQELKQASLETTEKSDEPKDVIEEVT
                     EAVVGKSQEQDSLSENAKLEDAEATLLANSAKPGVSETFSSHDDINNYLQQLDQLKGR
                     IAELEMEKQKDRELSQTLENEKNALLTQISAKDSELKLLEEEVAKINMLNQQIQEELS
                     RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNEQLESEMQNLKRC
                     VSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGSKIHAKELQELLKEKQQEVK
                     QLQKDCIRYLGRISALEKTVKALEFVHTESQKDLDATKGNLAQAVEHHKKAQAELSSF
                     KILLDDTQSEAARVLADNLKLKKELQSNKESIKSQIKQKDEDLLRRLEQAEEKHRKEK
                     KNMQEKLDALHREKAHVEDTLAEIQVSLTRKDKDMKELQQSLDSTLAQLAAFTKSMSS
                     LQDDRDRVIDEAKKWEQRFGDAIQTKEEEVRLKEENCTALKDQLRQMTIHMEELKITV
                     SRLEHDKEIWESKAQTELQHQQKAYDKLQEENKELMSQLEEAGQLYHDSKNELTKLES
                     ELKSLKDQSTDLKNSLEKCREHENNLEGIIKQQEADIQNCKFNCEQLETDLTASRELT
                     TRLHDEINVKEQKIISLLSGKEEAIQVAIAELHQQHSKEIKELENLLSQEEEENLTLE
                     EENKRAVEKTNQLTEALETIKKESLEQKAQLDSFVKSMSSLQDDRDRIVSDYRQLEER
                     HLSVILEKDELIQDAAAENNKLKEEIRGLRGHMDDLNSENAKLDAELIQYRRDLNEVI
                     TIKDSQQRQLLEAQLQQNKELRNECVKLEGRLKGSEAEKQSLQMSLDALQEENQGLSK
                     EIKSFKEQLTALHEEGALAVYHAQLRVREEEVQKLTAALSSSQKRTVDLQEELVCVQK
                     EASKKVSEIEDKLKRELKHLHHNAGIMRNETETAEERVAELARDLVEMEQKLLTVTKE
                     NKDLTAQIQAFGKSMSSLQDSRDHATEELSDLKKKYDASLKELAQLKGRQDLGRESDV
                     LSQAAFPLTTSENISSRLEKLNQQLTSKDEQLLHLSSELESSHNQVQSFTKAMTSLQN
                     ERDHLWNELEKFRKSEEGKQRSAAPSAASSPAEVQSLKKAMSSLQNDRDRLLKELKNL
                     QQQYLQMNQEITELRPLKAQLQESQDQTKALQMMKEELRQENLSWQHELHQLRVEKNS
                     WELHERRMKEQYLMAISDKDQQLGHLQNLLRELRSSSQTQILPTQYQRQASSGTSAAL
                     DGSQNLVYETDCLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNILSTQLRDANQS
                     LRDSQHHYSNLFNHCAILERQVQQLQATGPLNADVAPGAPQEKDGIHIKTETETTGEE
                     QPSFSEVQQQLCNTKHDLSELKKLLEEERDQRLTAENALSLAKEQIRRLEHSEWESAR
                     TPIIGACGSQEQVLLMDLPGSSCRRTRSSAGWKRVLRSLCRSRTRVPLLAAIYFLMIH
                     VLLVLCFTGHL"
     misc_feature    501..>857
                     /gene="Golgb1"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    501..>857
                     /gene="Golgb1"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    723..>3032
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    723..>3032
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2349..5060
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2349..5060
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    4872..6290
                     /gene="Golgb1"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     misc_feature    4872..6290
                     /gene="Golgb1"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     misc_feature    5817..8087
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    5817..8087
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    7146..>9395
                     /gene="Golgb1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    7146..>9395
                     /gene="Golgb1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            408..560
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..710
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..839
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..965
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1079
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1461
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1577
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1692
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1766
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..6889
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6890..8777
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8778..8956
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8957..9119
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9120..9257
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9258..9404
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9405..9502
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9503..9637
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9638..9743
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9744..11003
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcgagtg gctgactccc aggggcgcgt cggtggtggc gctgcgcttg ggttacccga
       61 gctgacgtgg cttagattgg gcggggggcg tccggagttg tctgggacgg ccacctacag
      121 tgcttgaaga ggtcagaaaa ggacatcaga tcctctagga ctagagttac ggacggttgt
      181 gagcagccac gtggatactg agaggcgaac cctaggccct ctggaagagc agctggtgct
      241 cttaacctct gaccaactct gcagacccca ctgtgagtca tttttctccg tgcccatgga
      301 gcgctccttc agagatgctg agccgattat cgggattagc aaataatgtt ttgcatgaat
      361 tatcaggaga ttacactggc tggactacaa tgacttcctc ggaagctgaa ttaccccagg
      421 gttctgccat ggaattgaat aatagtaccc aaaaggacgt tctggatcgc ctggctgatg
      481 cagagaagtt agtgctggag ctaaaggata tcatcagtaa gcaggatgct cagctccagc
      541 aaaaggacga agctctgcag gaagaaaaaa aaggagctga aagcaaaatt aaaaaaataa
      601 aacttcatgc aaaggccaag atcacgtcct tgaacaaaca aatagaagaa ttgaagacac
      661 aaggaggagc tgcctcgcct ccagaagtgc aggcagagga gctctccaag catgataaga
      721 gttcaacaga agaggagatg gaggtagaaa aaataaaaca tgaactccag gagaaggaga
      781 aattaattag caatttgcaa gcccagctgg accaggcgca gtcagaacaa gcctcccagt
      841 tggataagag ttctgcggag atggaggact tcgtcctgat gaggcagaag ctccaagaga
      901 aggaggaact catcggcgct ttgcaaacgc agctcagcca gacacaggca gagcaagctg
      961 cccagaaatt gagggtgatg cagaggaagc ttgaggaaca cgaagaagcc ttgctgggcc
     1021 gagctcaggt tgtggacctg ctacagaagg agctgacttc tgcagaacag aggaaccagg
     1081 atctttcaca gcagttgcag ctgttggagg ctgaacacag tactttaagg aataccatgg
     1141 aagcagaaag acaggagtcc aagatcctga tggaaaaggt agaactcgaa atggcagaga
     1201 ggaaggaaga gctgtatcag cttcagggac agttggagcg agcaggccaa gcccaggctg
     1261 agctggagat gcagtacggt actctccagc aaagacatga gacagaaatg gaggagaaga
     1321 cagcttgcat ttcgcttctt cagaagaacg agcaggagct gcagtctgcc tgtgacgctc
     1381 tgaaggagga aaactccaag ctgcttcagg agcagcagga acaggctgcc aagtcagccc
     1441 aggccctgca gcagctggaa gatgaactcc agcaaaaatc taaagaaatt agccaatttg
     1501 taaacaaacc aaacttggaa aaacatgaga catcatctca gacgtcttta ccagatgttt
     1561 ataatgaggg cgtacaggca gtcatggagg agagtgtcgc ctctttacag aagagagtac
     1621 tagagctaga gaatgagaag ggagccttgc tccttagttc tctagagctg gaggagctga
     1681 gagctgagaa cgaaaaactc tgttctcgga ttactcttct ggaggctcag aatagagcag
     1741 gagaggctga tggtatggtc tgtgaggtca gcacagctgg tattgctttg ctcaacagga
     1801 gcgactcttc tactgaagaa agtggacagg atgtcctaga gaacacattt tctcagaaac
     1861 ataaagagct gtcggtttta ttagtggaaa tgaaggaagc ccaggaggaa attgcatttc
     1921 ttaagtcgca gctgcagggc aaaaggcctg aaggggacta tgaggtcctt gatcggaaag
     1981 aagtacagat gatggagagt gaaggactgc cctcagttac agcacgagat gtcctctgtg
     2041 cgccccgtga caagaacagt gtcccagcag tggaagggga acaggcaggc atgagagatc
     2101 agcacggaac attggaggcg ggacctctaa atgacaccgg aatggaactg aactccccac
     2161 agccggacgg tgtggacaaa tccctctctg caccacatgt ctgtctgtgt caccagggtg
     2221 aactggaaag gctgaaaact caagttttgg agcttgagac aagccttcat acagccaagg
     2281 aaactcatga gaagaattta agtgagaaag cgaaggaaat tagcagccta acccagctta
     2341 ccaaggagtt caaagagagt gcggaggaag cccgcagcac gctcactgct gtgtgtgaag
     2401 aaagagacca gctgctttac cgggtgaagg agcttgatgt ccttggagaa ctccgggctc
     2461 aggtccgaga actggaaacc agccttgcag aagcagagaa gcaaagaggt ctggactatg
     2521 aaagtcagag ggctcagcac aacctgctca ccgagcagat ccacagccta agcatagaag
     2581 ccaaatctaa agatgtgaaa atcgagactt tacagagaga gctggatggt gtgcaactac
     2641 aattttctga acagggaaca cagataagaa gcctacagag ccaactgcag acgaaggaaa
     2701 gtgaagtgct agagggggca gagcgtatga aggacatctc aaaagaaatg gaagaactgt
     2761 cgcaggcgct ttcacagaag gagctggaaa tagcccaaat ggaccaactc ttgttagaga
     2821 aaaagaaaga tgtggagaca ctccagcaaa ccatccagga gaaggatcag caagtgactg
     2881 aactcagctt cagtatgaca gagaaaatgg ttcagcttaa tgaagagaag ttttctcttg
     2941 gggtagaaat taagactctg aaggagcagc tcagtttatt gtccagagct gaaggagcaa
     3001 agaaagagca ggtagaagac agtggagctg agtccagccc taaacatggt ccacatgagt
     3061 cgagcgcaca ggagccagtg tgtaaagacg cactacagca agaacttgag tggctgagga
     3121 aagagagtga gcagaggaag cggaaactgc aggcagcgct gatcagcaga aaggagctac
     3181 tgcagaaagt cagcaagctg gaggaggagt tagccaaggt gagagaggag tccacaaaag
     3241 actccctcag ggagagtgag aagagagagc tggaggaaga cagcaagaac aaagatgacc
     3301 cagaaaagta tgggacttct gagtggaggg aactagaggt ttctttaaga ctgacaatat
     3361 ctgaaaagga agtggaactg gagggcataa ggagggactt aaaagaaaag gcagcagcag
     3421 aagaagagtt acaggccttg gtccaacgga tgactcagga cctgcagaat aagacaaagc
     3481 agatagactt gcttcaagaa gagatcactg aaaaccaagc aactattcag aaattcatca
     3541 caggcaccat ggatgctggg gatggagact cagcagtaaa ggaaacctcg gtgagcagcc
     3601 caccccgtgc agggggtggg gagcactgga agccggagct ggagggaaag atagtagacc
     3661 tggaaaaaga aaagactcaa cttcaaaaga agcttcaaga agccttaatt tcccgtaagg
     3721 caattctaaa aaaggcacaa gagaaagaga aacatctgaa ggaagagctc aaggagcaga
     3781 aggatgctta ccgtcaccta caggaacagt ttgatgggca gagtaaggaa aatgagaaca
     3841 ttgcggcccg cctaaggcaa ctccaagcaa aggagtctac agaccagcag ctcccaggca
     3901 ctggccagca ggagcccact cacggttcag aaggcctttc actcgaaggc acagagcctg
     3961 cttcagagtc tgacttacac gcagctcagc cttcgcaccc tggagagaca gcaactctcc
     4021 aggctaccgt ttctgttgcc cagattcagg accagctgaa agaaattgag gttgagaaag
     4081 aagagctgga attgaaaatt agttctacaa caagtgagct gaccaaaaaa tctgaagaag
     4141 tattactact acaagaacag atcaatgaac agggcttaga aatccagaat ttgaaggcag
     4201 cgtcccacga agccaaggcc cacacagaac agctgaagca agaattggaa agcagccaat
     4261 tgaaaattgc tgacctggaa catctgaaaa cattacagcc tgaactagaa acactgcaaa
     4321 agcacgtggg ccagaaggaa gaagaggtca gctaccttgt tggacagctt ggtgagaagg
     4381 agcagaccct caccaccgta cagacagaaa tggaggagca ggagcgttta atcaaggccc
     4441 tgcacacaca gctggaaatg caagccaagg agcatgagga gaggctaaag caggtccagg
     4501 tggaaatttg tgagctaaag aagcagccaa aagagcttga ggaagaaagt aaggcaaaac
     4561 agcaattaca gaggaaactg caggctgccc tcatctcccg gaaggaggcc ctcaaggaaa
     4621 acaagagtct gcaggagcag ttgtcctcgg ccagagatgc tgttgaacac ctgaccaaat
     4681 ctctggcaga tgtagagagc caggtttctg ttcagaatca agagaaagat gcactcctag
     4741 gaaagttagc ccttcttcag gaagaaaggg acaaactcat tgtagaaatg gacaagtctt
     4801 tactggaaaa tcagagcctt ggtggctctt gtgaaagcct gaagctagct ctcgggggcc
     4861 tcactgaaga caaggaaaag ctgatgaagg agctggaatc cgtgagatgt tctaagattg
     4921 cagagagcac cgaatggcaa gagaagcaca aggagctaca gaaagagtat gaagttcttc
     4981 tgcagtccta cgagaatgtg agcaatgagg cagagaggat tcaacacgtg gtggagagcg
     5041 tgaggcaaga gaagcaggag gtgtacgcaa agttaaggag cgcagagtca gacaagagag
     5101 agagagagaa gcagctgcag gatgcagaac aggaaatgga ggagatgaag gagaagatga
     5161 gaaagtttgc caaatctaag cagcagaaga tccttgagct agaggaagaa aacgaccgac
     5221 ttagagcaga ggcccagcct gtaggaggag ccaatgaaag catggaagct cttctttctt
     5281 ccaatgccag cttaaaggag gaactagaaa ggatcacatt ggagtataaa accctttcta
     5341 aggaatttga ggctttaatg gcagagaaga acactctgag tgaagagact cgtaatctga
     5401 agcttcaggt agaagctcag gaactgaaac aagctagcct cgagaccacc gagaagtccg
     5461 atgagccaaa ggatgtcatc gaagaggtaa cagaagccgt ggtaggcaag tctcaagaac
     5521 aagattccct gagtgaaaat gccaagcttg aagatgcaga agctactctc ttggctaaca
     5581 gtgccaagcc tggtgtcagt gagactttca gctcacacga tgacatcaat aactacctcc
     5641 agcagcttga tcagcttaaa ggaagaattg ctgagttaga gatggagaaa cagaaagaca
     5701 gggagcttag ccagactttg gaaaatgaaa aaaatgccct actgactcag atatctgcaa
     5761 aggatagtga gctcaagctc ctggaggaag aggttgccaa aataaacatg ctgaatcagc
     5821 aaatccaaga ggagctctcc agagtcacca agctgaaaga gacagcagag gaggagaaag
     5881 atgacttaga agagaggctg atgaatcaac tggcggaact taatgggagc atcgggaatt
     5941 attaccagga tgttacagac gcccaaataa agaacgagca actagagtca gaaatgcaga
     6001 accttaaaag atgtgtgagt gaattagaag aagaaaagca gcagctggtc aaggaaaaaa
     6061 ccaaggtgga gtcagaaata cgaaaagagt acatggaaaa gatacaaggt gcccagaagg
     6121 gacctggcag taaaatccac gccaaagagc tacaggagct gctcaaggaa aaacagcaag
     6181 aagtgaagca actgcagaag gactgcatcc ggtacctcgg caggatcagt gccctggaga
     6241 agaccgtcaa ggccctcgag tttgttcaca ctgaatccca aaaggatttg gatgcaacca
     6301 aaggaaatct ggctcaggcc gttgaacacc acaagaaggc acaggccgag ttatccagct
     6361 tcaagatact gctagatgac acccaaagcg aagcagcaag agtgctagcg gacaacctca
     6421 agttgaaaaa ggagcttcag tcaaacaaag agtccatcaa aagccagata aaacaaaaag
     6481 acgaagacct cttgcgaaga ctggagcaag cagaagagaa acaccgaaaa gagaagaaga
     6541 acatgcaaga gaagctggat gctttgcaca gagaaaaagc ccatgtggaa gacacgcttg
     6601 ccgagattca agtcagtctg accaggaaag acaaggacat gaaggagctg cagcaaagcc
     6661 tggacagcac cttggcccag cttgcggcct tcactaagag catgtcgtcc ctccaggatg
     6721 accgggacag ggtgatcgat gaagccaaga aatgggagca gaggttcggt gatgccattc
     6781 agaccaaaga ggaggaggtc agactcaaag aggagaactg cactgctcta aaggatcagc
     6841 tccgacaaat gaccatccac atggaggaac tgaagatcac cgtgtccagg cttgaacatg
     6901 acaaggaaat ttgggagtcc aaggcccaga ccgagctcca gcatcaacag aaggcttatg
     6961 ataagctgca agaagaaaat aaagaactta tgtcacagtt agaagaagct ggacagctgt
     7021 accatgattc taagaatgaa ttaactaagt tggaatcaga acttaagagt ctcaaagacc
     7081 aatcaactga cttaaagaac tctttagaaa aatgcagaga acacgaaaac aacttggaag
     7141 ggatcatcaa gcagcaagaa gctgacatcc agaattgtaa gttcaattgt gaacaactag
     7201 agactgacct gacagcctcc agagagctaa ccactcggct gcatgatgaa atcaatgtga
     7261 aggaacagaa gattataagc ctgctttctg gcaaggaaga ggcgatccaa gtagctatcg
     7321 cagaactgca ccaacagcac agtaaagaga tcaaagaatt agaaaacctg ttgtcccagg
     7381 aggaagagga gaatttgacc ttagaagagg aaaacaaaag ggctgttgag aaaaccaacc
     7441 agctcacaga agcactagaa accatcaaga aggagagcct tgagcagaag gctcagttgg
     7501 attcctttgt taagtccatg tcctctcttc aggacgaccg ggaccgcata gtaagtgact
     7561 accgacagct ggaagagcgg cacctttctg tgatcttgga aaaggacgag ctcatccaag
     7621 atgctgctgc tgagaataat aaactgaagg aggagattcg agggctgcga ggtcacatgg
     7681 atgacctcaa ctctgagaat gccaagctgg atgctgaact gatccagtat aggcgggacc
     7741 tgaatgaagt gatcaccata aaggactcgc agcaaaggca gctccttgag gctcagctgc
     7801 agcagaacaa agagctgaga aatgagtgtg taaagctaga aggaaggctg aaggggtcag
     7861 aggcagagaa gcagagcctg cagatgtcct tggacgccct ccaggaggag aatcaaggtt
     7921 tgtctaaaga gatcaaaagc ttcaaggagc agttgacggc cttgcacgag gaaggtgccc
     7981 tagctgtcta ccatgcccaa ctgagagtaa gagaggaaga agttcagaag ttaactgcgg
     8041 ctctctcctc ctctcagaag agaactgtgg atctgcaaga ggagttggtt tgtgtccaga
     8101 aggaggcaag caagaaggtg agtgagattg aagataagct gaagagggag ctgaagcatc
     8161 tccatcacaa cgcagggata atgcggaacg aaacagagac agcagaagag agggtggcag
     8221 agctggccag agacctcgtc gagatggaac agaagttgct tacggtaacc aaagagaata
     8281 aggatcttac ggcacagatt caggccttcg gaaagtcgat gagttccttg caggacagca
     8341 gagatcatgc cactgaggag ctgagtgacc tgaagaagaa gtatgatgcc agtctgaaag
     8401 agctggctca gctgaaaggg cggcaggact taggcagaga gagtgacgtt ctttcccagg
     8461 ctgcctttcc cctgaccacc tctgaaaaca tctcgtcccg ccttgagaaa ctgaaccagc
     8521 agctcacatc caaagacgag caattgcttc acttatcttc agaactagaa agttctcaca
     8581 accaagtgca gtccttcacc aaggccatga ccagcctaca gaatgagaga gatcacctgt
     8641 ggaatgagct ggagaaattc cggaagtcgg aggaagggaa gcagaggtct gcagcccctt
     8701 cagctgcctc cagcccagca gaagtacaga gcttgaaaaa agccatgtct tcactccaga
     8761 atgacagaga tcgattgctg aaggaactga agaatctaca acagcagtac ttacagatga
     8821 accaagagat caccgagctc cgtccgctga aggctcagct tcaggaatct caagatcaga
     8881 ccaaagccct gcagatgatg aaggaggagc tcaggcagga aaacctctcc tggcagcacg
     8941 agctgcatca gctcagagtg gagaagaact cttgggagct gcatgagaga agaatgaagg
     9001 aacagtacct tatggccatc tcagataaag atcagcagct tggccacctg cagaatctcc
     9061 tgagggaact gaggtcttcc tcccagactc agattctccc cacacagtac cagcgacagg
     9121 cgtcctcagg gacatcagct gccctcgacg ggtcacaaaa cctagtttat gaaacagact
     9181 gtctcaggac ccagctcaat gacagcttaa aggaaatcca tcagaaggag ctaagaattc
     9241 agcaactgaa cagcaagttc tctcagctgc ttgaggagaa gaacatcctc tccacccagc
     9301 tcagggacgc caaccagagt ctccgtgaca gccagcatca ctacagtaac ctcttcaacc
     9361 actgtgccat cctggagagg caggtgcagc agctgcaggc tacggggcca ctaaatgcag
     9421 atgttgctcc aggagcaccc caggaaaagg atgggattca cataaagact gaaactgaga
     9481 ccacagggga ggaacagcca agcttttctg aagtccagca gcagctgtgc aacactaaac
     9541 acgatctgag cgagctaaag aagctgctgg aagaagagcg agaccaaaga ctgaccgccg
     9601 aaaatgcact ctccctggcc aaggagcaga tcagacggtt ggagcatagc gagtgggagt
     9661 cagcccggac cccaatcatt ggcgcctgtg gctctcagga gcaggtgctg ttgatggatc
     9721 tcccaggcag tagctgtcgg aggacccgga gcagtgctgg atggaagcgg gttctgcgtt
     9781 ctctctgccg ttcccggacc cgcgtgccac tgctcgcagc catctacttc ctaatgattc
     9841 atgttttact ggttctgtgt ttcacgggtc acctataaac ttgttacttg acaactctcg
     9901 cacttgtaat tccttcatct gtagtgtcag gattgttgat cccagggcgg cctctcgctt
     9961 tgagcccacc ctcttggaaa gtgcctgtga aaagaggtgg ctgtgaggac aggcggcggt
    10021 aaggcctggc ctgccacatc cgctctcctt aaacacgtcg gcttctgaga tgtgccgtgt
    10081 tcactgcttc ttcagatgat gcagatccat atcccgtgtg gccttgcagg atgctgagag
    10141 aggctttcta gccgtgccaa caagatggtt ccaataaaca cagtaatctg gaatccagta
    10201 tcgctcttct tagtaacctg ctttgtcttg ttgcctgtat tttctcctgc ctcgggatga
    10261 atgcagagct gtgggcagtg agcacattgc cccataggac atgtgagcag tccttggagc
    10321 ctcgggggag ccggaaggct cccgggcttc agttgttgga tctcagggag gaaggcattt
    10381 tcttcctgcc tgttccatcg ccagtggggg gagggtgtgt tgctgggcat tgtcaggact
    10441 ggaccccagc agctttgcct tcggtcacat gtacactaag atactaagtg gccggtcttt
    10501 cctttccaaa aggcaggaag aactggtgat ggacagcaag gctcaaactc tatagtccta
    10561 ttttctggac gtgcctccat aggggtcctg agatggtgtc cagaggccag ccgggccatg
    10621 ccaaggtgaa ctggagtcag gtctgagtac cagtcacacc agcctcaaga actaccaagc
    10681 tgctgcactg cttgtgcggt gctggtttat tctgtctcca gcgccactgt caccttctgg
    10741 gaacaggggc taaggtggtg ggaagagaag gcgaagcacc tgaatccaga cctgaagagc
    10801 aatggctagg aatggatccc gctgtgttgg tcctcccctt tacggacatg atgtgcccct
    10861 tcctgttctc acccctaaag aagagagagc tgctgggctc actgatcaac ccactgttct
    10921 gtgttgatta aattttactc acaacatccc aaaaacttcc ctcaactact gtaaaataat
    10981 aaagttattt tcagaataag gaa
//
LOCUS       NM_001437696            4856 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 16,
            mRNA.
ACCESSION   NM_001437696 XM_039087901
VERSION     NM_001437696.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4856)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4856)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4856)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4856)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4856)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4856)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4856)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4856)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4856)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4856)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087901.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2216632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000011.1  98085846-98085923
            79-226              JAXUCZ010000011.1  98101064-98101211
            227-273             JAXUCZ010000011.1  98105694-98105740
            274-345             JAXUCZ010000011.1  98106090-98106161
            346-432             JAXUCZ010000011.1  98108322-98108408
            433-595             JAXUCZ010000011.1  98109928-98110090
            596-716             JAXUCZ010000011.1  98113029-98113149
            717-848             JAXUCZ010000011.1  98115531-98115662
            849-1055            JAXUCZ010000011.1  98117537-98117743
            1056-1176           JAXUCZ010000011.1  98123938-98124058
            1177-1332           JAXUCZ010000011.1  98124251-98124406
            1333-1422           JAXUCZ010000011.1  98124558-98124647
            1423-1515           JAXUCZ010000011.1  98126328-98126420
            1516-1572           JAXUCZ010000011.1  98128415-98128471
            1573-1650           JAXUCZ010000011.1  98129086-98129163
            1651-1683           JAXUCZ010000011.1  98129443-98129475
            1684-1878           JAXUCZ010000011.1  98131039-98131233
            1879-1988           JAXUCZ010000011.1  98131384-98131493
            1989-2148           JAXUCZ010000011.1  98133415-98133574
            2149-4856           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4856
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..78
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="upstream in-frame stop codon"
     exon            79..226
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..273
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..345
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..432
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2205
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 16 is encoded by transcript variant 16;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 16"
                     /protein_id="NP_001424625.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMAT
                     SEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLD
                     INNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRIN
                     VLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARIC
                     YIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLE
                     EPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV
                     HNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALA
                     PASQEPSPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGML
                     KTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLI
                     KSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQR
                     RKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    1912..2184
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1912..2184
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            433..595
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..716
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..848
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1055
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1176
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1332
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1515
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1572
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1650
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1683
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1878
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1988
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2148
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..4856
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgtcgc ttccttccgg cggctgaggt ccggacgggc tctggagttg cggtggacag
       61 aagggcagca agctagtgag cagtggaaag agctcagtgc tggaaagcct agtggggagg
      121 gaccttcttc ccagagggac tggtgtggtc acccggagac ctcttattct gcagctggtc
      181 cacgtttcac cagaagataa aagaaaaaca acaggagaag aaaatggagt tgaagcagaa
      241 gaatggggta aatttcttca caccaaaaac aagctttaca cagattttga tgaaattcga
      301 caagaaattg aaaatgaaac tgaaagaatt tcaggaaata ataagggagt aagccctgag
      361 ccaatccatc tcaaggtttt ctcgcccaac gttgtcaacc tgacgcttgt ggatttacca
      421 ggaatgacca aagtacctgt aggtgatcag cccaaggata ttgagcttca aatcagagaa
      481 cttattcttc ggttcatcag taatcccaat tccattatcc ttgctgtcac tgctgcaaat
      541 acagatatgg caacgtcaga ggcacttaag atttccagag aggtagatcc agatgggcgc
      601 agaactctag ctgtaatcac caagcttgat ctcatggatg cgggtactga tgccatggat
      661 gtattgatgg gaagggttat tccagtcaag cttggaataa ttggagtagt taacaggagc
      721 caactggaca ttaacaataa gaagagtgta actgattcaa tccgtgatga gtatgctttt
      781 cttcaaaaga agtacccatc tctggccaac agaaatggaa caaagtatct tgctaggact
      841 ctgaataggt tacttatgca tcatatcaga gactgtttac cagagctgaa aacaagaata
      901 aatgtcttag ctgctcagta tcagtctctt ctaaatagct atggtgagcc cgtggatgat
      961 aaaagtgcta ctttactcca gctcattacc aagtttgcca cagagtattg taacactatt
     1021 gaaggaacgg caaagtacat tgaaacttct gagctatgtg gtggtgctag gatttgttat
     1081 attttccatg agacttttgg gcgaacctta gaatctgttg atccactagg tggccttaac
     1141 actattgaca tcttgaccgc cattagaaat gctactggcc cccgtccagc tttatttgtg
     1201 cctgaagttt catttgagtt actggtcaaa cgtcagatta agcgtctaga ggagcccagc
     1261 ctccgctgtg tggagctggt ccacgaggaa atgcagagga tcattcagca ctgtagcaac
     1321 tacagcacac aggaactgtt acggttccct aaactccatg atgccatagt tgaagtagtg
     1381 acttgtcttc ttcgtaaaag gttgcccgtg acaaatgaaa tggtacataa cttagtggca
     1441 attgagctag catatatcaa cacaaaacac cccgactttg ctgatgcctg tgggctaatg
     1501 aacaataaca tagaggaaca aagaagaaac agactagcaa gagaactacc ttccgctgta
     1561 tcgcgagaca agtcttctaa agttccaagt gctttggcac ctgcctccca ggagccctcc
     1621 cctgccgctt ctgccgaggc tgatggcaag ttaattcagg acaacagaag agaaactaaa
     1681 aatgttgcat ctgcaggtgg tggaattgga gatggtggtc gaattggaga tggtggtcag
     1741 gaaccgacaa caggcaactg gagaggaatg ctgaaaactt caaaagctga agaattactt
     1801 gctgaagaaa aatcaaaacc aattccaatt atgccagcaa gtccacaaaa aggccatgct
     1861 gtcaatttgc tagatgtgcc agttccagtt gcacgaaaac tgtctgcccg agaacagcga
     1921 gattgtgagg ttattgaaag actcatcaaa tcatattttc taattgtcag aaagaatatt
     1981 caagacagcg tcccaaaggc agtaatgcat tttttggtta atcatgtgaa agatactctt
     2041 cagagtgaat tagtagggca gctgtataag tcatccttat tagatgacct tctgactgaa
     2101 tccgaggaca tggcacagcg aagaaaagaa gcggctgaca tgctgaaggc attacaagga
     2161 gccagtcaaa ttattgctga aatccgagag actcatcttt ggtgaacaga actgtttggt
     2221 cttctacact ttgctgactt gaacctacta gctactgcct acctgagtag aaatttattt
     2281 atggactttt gtgtatcgca gtgtatgaat ttgcttgtgt gaagactggc tataagctga
     2341 aaagtatatt attcattaca agacaaatca catgtttaat tcacattttt caagtttcct
     2401 atgatgtata tcaagtctgt ccgtttcagt caaacttaca agaacaattg atgttctagt
     2461 tgtacaaagc agtttgcctg tgcatatgat gacctgcgta accttttttt agtcttaaag
     2521 ctgcagccgt agtcctcaaa gaggaagctc caggacattt catgactata atgcatgcac
     2581 tatttatata gactgacctg gcttcaaaag gtggagcctg gcgagttcct cacataatca
     2641 atgtatccac ctatccttca tttttatagt cttaaaaaac aaacaaaatt ctgaaacttc
     2701 tgcagtttta ggaaaaatat aagatctgaa agactcataa agatgtagga acagactgtg
     2761 taattaatgg ctcctgagtc tatactgccc taatgttaga aagtaaaata tgctttgatt
     2821 caaaataagc ctgaaaatat aaattgactt cctgcattaa aaataactat taggaacttt
     2881 cttagtaaca ataactggtc ctgttagttt ctaaatgact cagtgacaac ctaaatttcc
     2941 ctaatttaca agtacatcga ttgcagtcca gatgcacctt agggtggggc gctgactctg
     3001 ggctccgaga ctcagttatg tgagacctaa aagtctactc tgtatccact ggtaatgcta
     3061 ctttatagtt ccacaccaac agaatacatt tgtcaaagaa aaatacctgg acatacacat
     3121 acacctaaaa gcttatggac tactaaactg tattcagggg ttgaggattt acaacctatt
     3181 ttgtgaaaac tgcctgtgca attcaatttc tgacctagct gggcagtggt ggtgcacacc
     3241 tttaatccca gcttttggga ggcagaggca ggtggatctc tgagttcaag gccagcctgg
     3301 tctacagagt tgagttccaa gacaaccaga actacacaga gaaaccctgt cttgaacccc
     3361 cctcccccca aaaaattgaa acctaaatag aaatctttga tgtatctagt tttctctgac
     3421 caaatgatac atttgtgtta taaatactaa aattcttttc aggtcaggca tcttatgaaa
     3481 tactattagc aaggaaaaca agaacatgtt atctttagtt tagatgccca ttgaaccatc
     3541 tcaaaaacaa aggcagtctg ataacagtac cagcttgaca gtgagtatac actgcctaaa
     3601 tgtgttagca tacttaagaa aaatatcctg ttatctaact attaggtatc catggtttat
     3661 tttttaagag agatgaccac cactgtagcc ttttgaattt gtaaagagaa agaatgcacc
     3721 tttatccaac atttcaaata gattttaaaa ggaagatgtt agctttaaaa acgtgctatg
     3781 ataatgtact tgttagcact acacactttg tacaaagaaa aacaagcaag aaaggtaggg
     3841 aaatgaaagc ttcctttgtg tacttttaca ctaagctgtg ttctgaaaca tggagataat
     3901 ttataagacc actgtatgtt ctatgtaaat aaaaatgctg gtgtgaaatg gcattacggt
     3961 ttgccagtaa gtgaattctt cctgacttgc cgtaagagag aggtttaaat aggtgcatct
     4021 ttgaaatatc tgaatctact tcataatgga acgatttaaa ttgtactgca ccaaaagttt
     4081 tatgccattt ttttaattag ataatcacca ccaaggcctt gttacatctt tgtgtctaca
     4141 gatgaagaca gaaacttctt ccaagtaatc caaggatgaa tgctgagaac atgaactttg
     4201 ctgcaagacg tctagaagct gatccacagt ttatgtttca cccctatgta cattggggtg
     4261 gtgctatctt gatttttaca gaaactgttt ttgagaatta gcttgccttg tgtatacaaa
     4321 cctgaactag tttgacttca aaacttcctg tatcttttct gttcttactg actgcatact
     4381 tgatgagata ctttttgttt ctttggtttc ttaaaatatc tgctatagga acccactggc
     4441 aaaaataggc agttatcagt aaattattga aacacagaac aaggaagtgg aaaactgaac
     4501 tataaatgaa gtctggtact gattgatgtt ttgttttaag aaaaaactat tttgtactac
     4561 agtttctatt gggaaccact gccatatcta actccttttt aagaattctg tttgcttggc
     4621 agcatcaatc agaagtttaa ctttgtaaca gatttctcac atctaaacag acattagaag
     4681 cttggccagt ttgtacagct atgtaacaca actgcaatca ggtgcttacc ttacctcctg
     4741 tgttaacttt atacagtcat ttccactgca ccacttcttc agaccaagga gcaagaaaga
     4801 tcattcttgc ataaagaaat gaactataat taaatatcac tttattttga aatgca
//
LOCUS       NM_001437692            4954 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 12,
            mRNA.
ACCESSION   NM_001437692 XM_039087898
VERSION     NM_001437692.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4954)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4954)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4954)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4954)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4954)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4954)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4954)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4954)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4954)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4954)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087898.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.70323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-449             JAXUCZ010000011.1  98105694-98105740
            450-521             JAXUCZ010000011.1  98106090-98106161
            522-608             JAXUCZ010000011.1  98108322-98108408
            609-771             JAXUCZ010000011.1  98109928-98110090
            772-892             JAXUCZ010000011.1  98113029-98113149
            893-1024            JAXUCZ010000011.1  98115531-98115662
            1025-1231           JAXUCZ010000011.1  98117537-98117743
            1232-1352           JAXUCZ010000011.1  98123938-98124058
            1353-1508           JAXUCZ010000011.1  98124251-98124406
            1509-1598           JAXUCZ010000011.1  98124558-98124647
            1599-1691           JAXUCZ010000011.1  98126328-98126420
            1692-1748           JAXUCZ010000011.1  98128415-98128471
            1749-1781           JAXUCZ010000011.1  98129443-98129475
            1782-1976           JAXUCZ010000011.1  98131039-98131233
            1977-2086           JAXUCZ010000011.1  98131384-98131493
            2087-2246           JAXUCZ010000011.1  98133415-98133574
            2247-4954           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4954
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2303
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 12 is encoded by transcript variant 12;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 12"
                     /protein_id="NP_001424621.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWRVEAEEWGKFLHT
                     KNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVP
                     VGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLA
                     VITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQ
                     KKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDD
                     KSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGG
                     LNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQ
                     HCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFA
                     DACGLMNNNIEEQRRNRLARELPSAVSRDKLIQDNRRETKNVASAGGGIGDGGRIGDG
                     GQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSA
                     REQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLL
                     DDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2010..2282
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2010..2282
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..449
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..521
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..608
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..892
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1024
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1231
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1352
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1508
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1598
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1691
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1748
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1781
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1976
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2086
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2246
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..4954
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gagagttgaa gcagaagaat
      421 ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa attcgacaag
      481 aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc cctgagccaa
      541 tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat ttaccaggaa
      601 tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc agagaactta
      661 ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct gcaaatacag
      721 atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat gggcgcagaa
      781 ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc atggatgtat
      841 tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac aggagccaac
      901 tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat gcttttcttc
      961 aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct aggactctga
     1021 ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca agaataaatg
     1081 tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg gatgataaaa
     1141 gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac actattgaag
     1201 gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt tgttatattt
     1261 tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc cttaacacta
     1321 ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta tttgtgcctg
     1381 aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag cccagcctcc
     1441 gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt agcaactaca
     1501 gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa gtagtgactt
     1561 gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta gtggcaattg
     1621 agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg ctaatgaaca
     1681 ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc gctgtatcgc
     1741 gagacaagtt aattcaggac aacagaagag aaactaaaaa tgttgcatct gcaggtggtg
     1801 gaattggaga tggtggtcga attggagatg gtggtcagga accgacaaca ggcaactgga
     1861 gaggaatgct gaaaacttca aaagctgaag aattacttgc tgaagaaaaa tcaaaaccaa
     1921 ttccaattat gccagcaagt ccacaaaaag gccatgctgt caatttgcta gatgtgccag
     1981 ttccagttgc acgaaaactg tctgcccgag aacagcgaga ttgtgaggtt attgaaagac
     2041 tcatcaaatc atattttcta attgtcagaa agaatattca agacagcgtc ccaaaggcag
     2101 taatgcattt tttggttaat catgtgaaag atactcttca gagtgaatta gtagggcagc
     2161 tgtataagtc atccttatta gatgaccttc tgactgaatc cgaggacatg gcacagcgaa
     2221 gaaaagaagc ggctgacatg ctgaaggcat tacaaggagc cagtcaaatt attgctgaaa
     2281 tccgagagac tcatctttgg tgaacagaac tgtttggtct tctacacttt gctgacttga
     2341 acctactagc tactgcctac ctgagtagaa atttatttat ggacttttgt gtatcgcagt
     2401 gtatgaattt gcttgtgtga agactggcta taagctgaaa agtatattat tcattacaag
     2461 acaaatcaca tgtttaattc acatttttca agtttcctat gatgtatatc aagtctgtcc
     2521 gtttcagtca aacttacaag aacaattgat gttctagttg tacaaagcag tttgcctgtg
     2581 catatgatga cctgcgtaac ctttttttag tcttaaagct gcagccgtag tcctcaaaga
     2641 ggaagctcca ggacatttca tgactataat gcatgcacta tttatataga ctgacctggc
     2701 ttcaaaaggt ggagcctggc gagttcctca cataatcaat gtatccacct atccttcatt
     2761 tttatagtct taaaaaacaa acaaaattct gaaacttctg cagttttagg aaaaatataa
     2821 gatctgaaag actcataaag atgtaggaac agactgtgta attaatggct cctgagtcta
     2881 tactgcccta atgttagaaa gtaaaatatg ctttgattca aaataagcct gaaaatataa
     2941 attgacttcc tgcattaaaa ataactatta ggaactttct tagtaacaat aactggtcct
     3001 gttagtttct aaatgactca gtgacaacct aaatttccct aatttacaag tacatcgatt
     3061 gcagtccaga tgcaccttag ggtggggcgc tgactctggg ctccgagact cagttatgtg
     3121 agacctaaaa gtctactctg tatccactgg taatgctact ttatagttcc acaccaacag
     3181 aatacatttg tcaaagaaaa atacctggac atacacatac acctaaaagc ttatggacta
     3241 ctaaactgta ttcaggggtt gaggatttac aacctatttt gtgaaaactg cctgtgcaat
     3301 tcaatttctg acctagctgg gcagtggtgg tgcacacctt taatcccagc ttttgggagg
     3361 cagaggcagg tggatctctg agttcaaggc cagcctggtc tacagagttg agttccaaga
     3421 caaccagaac tacacagaga aaccctgtct tgaacccccc tccccccaaa aaattgaaac
     3481 ctaaatagaa atctttgatg tatctagttt tctctgacca aatgatacat ttgtgttata
     3541 aatactaaaa ttcttttcag gtcaggcatc ttatgaaata ctattagcaa ggaaaacaag
     3601 aacatgttat ctttagttta gatgcccatt gaaccatctc aaaaacaaag gcagtctgat
     3661 aacagtacca gcttgacagt gagtatacac tgcctaaatg tgttagcata cttaagaaaa
     3721 atatcctgtt atctaactat taggtatcca tggtttattt tttaagagag atgaccacca
     3781 ctgtagcctt ttgaatttgt aaagagaaag aatgcacctt tatccaacat ttcaaataga
     3841 ttttaaaagg aagatgttag ctttaaaaac gtgctatgat aatgtacttg ttagcactac
     3901 acactttgta caaagaaaaa caagcaagaa aggtagggaa atgaaagctt cctttgtgta
     3961 cttttacact aagctgtgtt ctgaaacatg gagataattt ataagaccac tgtatgttct
     4021 atgtaaataa aaatgctggt gtgaaatggc attacggttt gccagtaagt gaattcttcc
     4081 tgacttgccg taagagagag gtttaaatag gtgcatcttt gaaatatctg aatctacttc
     4141 ataatggaac gatttaaatt gtactgcacc aaaagtttta tgccattttt ttaattagat
     4201 aatcaccacc aaggccttgt tacatctttg tgtctacaga tgaagacaga aacttcttcc
     4261 aagtaatcca aggatgaatg ctgagaacat gaactttgct gcaagacgtc tagaagctga
     4321 tccacagttt atgtttcacc cctatgtaca ttggggtggt gctatcttga tttttacaga
     4381 aactgttttt gagaattagc ttgccttgtg tatacaaacc tgaactagtt tgacttcaaa
     4441 acttcctgta tcttttctgt tcttactgac tgcatacttg atgagatact ttttgtttct
     4501 ttggtttctt aaaatatctg ctataggaac ccactggcaa aaataggcag ttatcagtaa
     4561 attattgaaa cacagaacaa ggaagtggaa aactgaacta taaatgaagt ctggtactga
     4621 ttgatgtttt gttttaagaa aaaactattt tgtactacag tttctattgg gaaccactgc
     4681 catatctaac tcctttttaa gaattctgtt tgcttggcag catcaatcag aagtttaact
     4741 ttgtaacaga tttctcacat ctaaacagac attagaagct tggccagttt gtacagctat
     4801 gtaacacaac tgcaatcagg tgcttacctt acctcctgtg ttaactttat acagtcattt
     4861 ccactgcacc acttcttcag accaaggagc aagaaagatc attcttgcat aaagaaatga
     4921 actataatta aatatcactt tattttgaaa tgca
//
LOCUS       NM_001437699            4763 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 19,
            mRNA.
ACCESSION   NM_001437699 XM_063270240
VERSION     NM_001437699.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4763)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4763)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4763)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4763)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4763)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270240.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.603237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000011.1  98085846-98085923
            79-244              JAXUCZ010000011.1  98101064-98101229
            245-291             JAXUCZ010000011.1  98105694-98105740
            292-363             JAXUCZ010000011.1  98106090-98106161
            364-450             JAXUCZ010000011.1  98108322-98108408
            451-613             JAXUCZ010000011.1  98109928-98110090
            614-734             JAXUCZ010000011.1  98113029-98113149
            735-866             JAXUCZ010000011.1  98115531-98115662
            867-1073            JAXUCZ010000011.1  98117537-98117743
            1074-1194           JAXUCZ010000011.1  98123938-98124058
            1195-1350           JAXUCZ010000011.1  98124251-98124406
            1351-1440           JAXUCZ010000011.1  98124558-98124647
            1441-1533           JAXUCZ010000011.1  98126328-98126420
            1534-1590           JAXUCZ010000011.1  98128415-98128471
            1591-1785           JAXUCZ010000011.1  98131039-98131233
            1786-1895           JAXUCZ010000011.1  98131384-98131493
            1896-2055           JAXUCZ010000011.1  98133415-98133574
            2056-4763           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4763
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..78
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="upstream in-frame stop codon"
     exon            79..244
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..291
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..363
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..450
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..2112
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 19 is encoded by transcript variant 19;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 19"
                     /protein_id="NP_001424628.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMAT
                     SEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLD
                     INNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRIN
                     VLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARIC
                     YIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLE
                     EPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV
                     HNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKVASAGGGIG
                     DGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPV
                     PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVG
                     QLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    <442..759
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <442..759
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    667..1524
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    667..1524
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    1819..2091
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1819..2091
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            451..613
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..734
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..866
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1073
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1194
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1350
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1440
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1533
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1590
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1785
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1895
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2055
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..4763
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgtcgc ttccttccgg cggctgaggt ccggacgggc tctggagttg cggtggacag
       61 aagggcagca agctagtgag cagtggaaag agctcagtgc tggaaagcct agtggggagg
      121 gaccttcttc ccagagggac tggtgtggtc acccggagac ctcttattct gcagctggtc
      181 cacgtttcac cagaagataa aagaaaaaca acaggagaag aaaatggtaa atttcagagc
      241 tggagagttg aagcagaaga atggggtaaa tttcttcaca ccaaaaacaa gctttacaca
      301 gattttgatg aaattcgaca agaaattgaa aatgaaactg aaagaatttc aggaaataat
      361 aagggagtaa gccctgagcc aatccatctc aaggttttct cgcccaacgt tgtcaacctg
      421 acgcttgtgg atttaccagg aatgaccaaa gtacctgtag gtgatcagcc caaggatatt
      481 gagcttcaaa tcagagaact tattcttcgg ttcatcagta atcccaattc cattatcctt
      541 gctgtcactg ctgcaaatac agatatggca acgtcagagg cacttaagat ttccagagag
      601 gtagatccag atgggcgcag aactctagct gtaatcacca agcttgatct catggatgcg
      661 ggtactgatg ccatggatgt attgatggga agggttattc cagtcaagct tggaataatt
      721 ggagtagtta acaggagcca actggacatt aacaataaga agagtgtaac tgattcaatc
      781 cgtgatgagt atgcttttct tcaaaagaag tacccatctc tggccaacag aaatggaaca
      841 aagtatcttg ctaggactct gaataggtta cttatgcatc atatcagaga ctgtttacca
      901 gagctgaaaa caagaataaa tgtcttagct gctcagtatc agtctcttct aaatagctat
      961 ggtgagcccg tggatgataa aagtgctact ttactccagc tcattaccaa gtttgccaca
     1021 gagtattgta acactattga aggaacggca aagtacattg aaacttctga gctatgtggt
     1081 ggtgctagga tttgttatat tttccatgag acttttgggc gaaccttaga atctgttgat
     1141 ccactaggtg gccttaacac tattgacatc ttgaccgcca ttagaaatgc tactggcccc
     1201 cgtccagctt tatttgtgcc tgaagtttca tttgagttac tggtcaaacg tcagattaag
     1261 cgtctagagg agcccagcct ccgctgtgtg gagctggtcc acgaggaaat gcagaggatc
     1321 attcagcact gtagcaacta cagcacacag gaactgttac ggttccctaa actccatgat
     1381 gccatagttg aagtagtgac ttgtcttctt cgtaaaaggt tgcccgtgac aaatgaaatg
     1441 gtacataact tagtggcaat tgagctagca tatatcaaca caaaacaccc cgactttgct
     1501 gatgcctgtg ggctaatgaa caataacata gaggaacaaa gaagaaacag actagcaaga
     1561 gaactacctt ccgctgtatc gcgagacaag gttgcatctg caggtggtgg aattggagat
     1621 ggtggtcgaa ttggagatgg tggtcaggaa ccgacaacag gcaactggag aggaatgctg
     1681 aaaacttcaa aagctgaaga attacttgct gaagaaaaat caaaaccaat tccaattatg
     1741 ccagcaagtc cacaaaaagg ccatgctgtc aatttgctag atgtgccagt tccagttgca
     1801 cgaaaactgt ctgcccgaga acagcgagat tgtgaggtta ttgaaagact catcaaatca
     1861 tattttctaa ttgtcagaaa gaatattcaa gacagcgtcc caaaggcagt aatgcatttt
     1921 ttggttaatc atgtgaaaga tactcttcag agtgaattag tagggcagct gtataagtca
     1981 tccttattag atgaccttct gactgaatcc gaggacatgg cacagcgaag aaaagaagcg
     2041 gctgacatgc tgaaggcatt acaaggagcc agtcaaatta ttgctgaaat ccgagagact
     2101 catctttggt gaacagaact gtttggtctt ctacactttg ctgacttgaa cctactagct
     2161 actgcctacc tgagtagaaa tttatttatg gacttttgtg tatcgcagtg tatgaatttg
     2221 cttgtgtgaa gactggctat aagctgaaaa gtatattatt cattacaaga caaatcacat
     2281 gtttaattca catttttcaa gtttcctatg atgtatatca agtctgtccg tttcagtcaa
     2341 acttacaaga acaattgatg ttctagttgt acaaagcagt ttgcctgtgc atatgatgac
     2401 ctgcgtaacc tttttttagt cttaaagctg cagccgtagt cctcaaagag gaagctccag
     2461 gacatttcat gactataatg catgcactat ttatatagac tgacctggct tcaaaaggtg
     2521 gagcctggcg agttcctcac ataatcaatg tatccaccta tccttcattt ttatagtctt
     2581 aaaaaacaaa caaaattctg aaacttctgc agttttagga aaaatataag atctgaaaga
     2641 ctcataaaga tgtaggaaca gactgtgtaa ttaatggctc ctgagtctat actgccctaa
     2701 tgttagaaag taaaatatgc tttgattcaa aataagcctg aaaatataaa ttgacttcct
     2761 gcattaaaaa taactattag gaactttctt agtaacaata actggtcctg ttagtttcta
     2821 aatgactcag tgacaaccta aatttcccta atttacaagt acatcgattg cagtccagat
     2881 gcaccttagg gtggggcgct gactctgggc tccgagactc agttatgtga gacctaaaag
     2941 tctactctgt atccactggt aatgctactt tatagttcca caccaacaga atacatttgt
     3001 caaagaaaaa tacctggaca tacacataca cctaaaagct tatggactac taaactgtat
     3061 tcaggggttg aggatttaca acctattttg tgaaaactgc ctgtgcaatt caatttctga
     3121 cctagctggg cagtggtggt gcacaccttt aatcccagct tttgggaggc agaggcaggt
     3181 ggatctctga gttcaaggcc agcctggtct acagagttga gttccaagac aaccagaact
     3241 acacagagaa accctgtctt gaacccccct ccccccaaaa aattgaaacc taaatagaaa
     3301 tctttgatgt atctagtttt ctctgaccaa atgatacatt tgtgttataa atactaaaat
     3361 tcttttcagg tcaggcatct tatgaaatac tattagcaag gaaaacaaga acatgttatc
     3421 tttagtttag atgcccattg aaccatctca aaaacaaagg cagtctgata acagtaccag
     3481 cttgacagtg agtatacact gcctaaatgt gttagcatac ttaagaaaaa tatcctgtta
     3541 tctaactatt aggtatccat ggtttatttt ttaagagaga tgaccaccac tgtagccttt
     3601 tgaatttgta aagagaaaga atgcaccttt atccaacatt tcaaatagat tttaaaagga
     3661 agatgttagc tttaaaaacg tgctatgata atgtacttgt tagcactaca cactttgtac
     3721 aaagaaaaac aagcaagaaa ggtagggaaa tgaaagcttc ctttgtgtac ttttacacta
     3781 agctgtgttc tgaaacatgg agataattta taagaccact gtatgttcta tgtaaataaa
     3841 aatgctggtg tgaaatggca ttacggtttg ccagtaagtg aattcttcct gacttgccgt
     3901 aagagagagg tttaaatagg tgcatctttg aaatatctga atctacttca taatggaacg
     3961 atttaaattg tactgcacca aaagttttat gccatttttt taattagata atcaccacca
     4021 aggccttgtt acatctttgt gtctacagat gaagacagaa acttcttcca agtaatccaa
     4081 ggatgaatgc tgagaacatg aactttgctg caagacgtct agaagctgat ccacagttta
     4141 tgtttcaccc ctatgtacat tggggtggtg ctatcttgat ttttacagaa actgtttttg
     4201 agaattagct tgccttgtgt atacaaacct gaactagttt gacttcaaaa cttcctgtat
     4261 cttttctgtt cttactgact gcatacttga tgagatactt tttgtttctt tggtttctta
     4321 aaatatctgc tataggaacc cactggcaaa aataggcagt tatcagtaaa ttattgaaac
     4381 acagaacaag gaagtggaaa actgaactat aaatgaagtc tggtactgat tgatgttttg
     4441 ttttaagaaa aaactatttt gtactacagt ttctattggg aaccactgcc atatctaact
     4501 cctttttaag aattctgttt gcttggcagc atcaatcaga agtttaactt tgtaacagat
     4561 ttctcacatc taaacagaca ttagaagctt ggccagtttg tacagctatg taacacaact
     4621 gcaatcaggt gcttacctta cctcctgtgt taactttata cagtcatttc cactgcacca
     4681 cttcttcaga ccaaggagca agaaagatca ttcttgcata aagaaatgaa ctataattaa
     4741 atatcacttt attttgaaat gca
//
LOCUS       NM_133601               6315 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus Cbl proto-oncogene B (Cblb), transcript variant
            1, mRNA.
ACCESSION   NM_133601
VERSION     NM_133601.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6315)
  AUTHORS   Zhang,Z.Y., Bai,H.H., Guo,Z., Li,H.L., Diao,X.T., Zhang,T.Y.,
            Yao,L., Ma,J.J., Cao,Z., Li,Y.X., Bai,X., Chen,H.K., Suo,Z.W.,
            Yang,X. and Hu,X.D.
  TITLE     Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn
  JOURNAL   Sci Signal 13 (638) (2020)
   PUBMED   32606037
  REMARK    GeneRIF: Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6315)
  AUTHORS   Jeong,J.S., Kim,H.Y., Shin,B.S., Lee,A.R., Yoon,J.H., Hahm,T.S. and
            Lee,J.E.
  TITLE     Increased expression of the Cbl family of E3 ubiquitin ligases
            decreases Interleukin-2 production in a rat model of peripheral
            neuropathy
  JOURNAL   BMC Anesthesiol 18 (1), 87 (2018)
   PUBMED   30021515
  REMARK    GeneRIF: results suggest that ubiquitin and the E3 ubiquitin
            ligases c-Cbl and Cbl-b function as neuroimmune modulators in the
            subacute phase of neuropathic pain after nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6315)
  AUTHORS   Uchida,T., Sakashita,Y., Kitahata,K., Yamashita,Y., Tomida,C.,
            Kimori,Y., Komatsu,A., Hirasaka,K., Ohno,A., Nakao,R.,
            Higashitani,A., Higashibata,A., Ishioka,N., Shimazu,T.,
            Kobayashi,T., Okumura,Y., Choi,I., Oarada,M., Mills,E.M.,
            Teshima-Kondo,S., Takeda,S., Tanaka,E., Tanaka,K., Sokabe,M. and
            Nikawa,T.
  TITLE     Reactive oxygen species upregulate expression of muscle
            atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 314 (6), C721-C731 (2018)
   PUBMED   29513566
  REMARK    GeneRIF: Under microgravity conditions, elevated ROS may be a
            crucial mechanotransducer in skeletal muscle cells, regulating
            muscle mass through Cbl-b expression activated by the ERK-Egr
            signaling pathway.
REFERENCE   4  (bases 1 to 6315)
  AUTHORS   Li,P., Liu,H.L., Zhang,Z.Q., Lv,X.D., Chang,Y.X., Wang,H.J., Ma,J.,
            Ma,Z.Y., Qu,X.J. and Teng,Y.E.
  TITLE     Single nucleotide polymorphisms of casitas B-lineage lymphoma
            proto-oncogene-b predict outcomes of patients with advanced
            non-small cell lung cancer after first-line platinum based doublet
            chemotherapy
  JOURNAL   J Thorac Dis 10 (3), 1635-1647 (2018)
   PUBMED   29707316
REFERENCE   5  (bases 1 to 6315)
  AUTHORS   Li,P., Liu,H., Zhang,Z., Lv,X., Wang,H., Ma,J., Ma,Z., Qu,X. and
            Teng,Y.E.
  TITLE     Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma
            and Adenocarcinoma
  JOURNAL   Med Sci Monit 24, 623-635 (2018)
   PUBMED   29384143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6315)
  AUTHORS   Thirone,A.C., Carvalheira,J.B., Hirata,A.E., Velloso,L.A. and
            Saad,M.J.
  TITLE     Regulation of Cbl-associated protein/Cbl pathway in muscle and
            adipose tissues of two animal models of insulin resistance
  JOURNAL   Endocrinology 145 (1), 281-293 (2004)
   PUBMED   14525909
  REMARK    GeneRIF: CAP-Cbl pathway may have a role in the modulation of
            adiposity in fasting and in monosodium glutamate treated rats.
REFERENCE   7  (bases 1 to 6315)
  AUTHORS   Zhang,W., Shao,Y., Fang,D., Huang,J., Jeon,M.S. and Liu,Y.C.
  TITLE     Negative regulation of T cell antigen receptor-mediated Crk-L-C3G
            signaling and cell adhesion by Cbl-b
  JOURNAL   J Biol Chem 278 (26), 23978-23983 (2003)
   PUBMED   12697763
REFERENCE   8  (bases 1 to 6315)
  AUTHORS   Nishio,H., Otsuka,M., Kinoshita,S., Tokuoka,T., Nakajima,M.,
            Noda,Y., Fukuyama,Y. and Suzuki,K.
  TITLE     Phosphorylation of c-Cbl protooncogene product following ethanol
            administration in rat cerebellum: possible involvement of Fyn
            kinase
  JOURNAL   Brain Res 950 (1-2), 203-209 (2002)
   PUBMED   12231245
  REMARK    GeneRIF: c-Cbl protooncogene product is tyrosine- phosphorylated in
            rat cerebellum in response to ethanol administration.
REFERENCE   9  (bases 1 to 6315)
  AUTHORS   Yokoi,N., Komeda,K., Wang,H.Y., Yano,H., Kitada,K., Saitoh,Y.,
            Seino,Y., Yasuda,K., Serikawa,T. and Seino,S.
  TITLE     Cblb is a major susceptibility gene for rat type 1 diabetes
            mellitus
  JOURNAL   Nat Genet 31 (4), 391-394 (2002)
   PUBMED   12118252
  REMARK    GeneRIF: we report the positional cloning of Iddm/kdp1 and identify
            a nonsense mutation in Cblb, a member of the Cbl/Sli family of
            ubiquitin-protein ligases.Cblb is a major susceptibility gene for
            rat type 1 diabetes mellitus
REFERENCE   10 (bases 1 to 6315)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_133601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071283.1, SRR26360172.345295.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000011.1  62225753-62225896   c
            145-330             JAXUCZ010000011.1  62224275-62224460   c
            331-581             JAXUCZ010000011.1  62210550-62210800   c
            582-728             JAXUCZ010000011.1  62149944-62150090   c
            729-885             JAXUCZ010000011.1  62132129-62132285   c
            886-1007            JAXUCZ010000011.1  62127140-62127261   c
            1008-1145           JAXUCZ010000011.1  62123379-62123516   c
            1146-1233           JAXUCZ010000011.1  62121947-62122034   c
            1234-1365           JAXUCZ010000011.1  62119699-62119830   c
            1366-1569           JAXUCZ010000011.1  62109937-62110140   c
            1570-1755           JAXUCZ010000011.1  62099325-62099510   c
            1756-2118           JAXUCZ010000011.1  62097450-62097812   c
            2119-2213           JAXUCZ010000011.1  62090404-62090498   c
            2214-2360           JAXUCZ010000011.1  62081938-62082084   c
            2361-2458           JAXUCZ010000011.1  62079026-62079123   c
            2459-2599           JAXUCZ010000011.1  62076111-62076251   c
            2600-2719           JAXUCZ010000011.1  62070742-62070861   c
            2720-6315           JAXUCZ010000011.1  62058829-62062424   c
FEATURES             Location/Qualifiers
     source          1..6315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..6315
                     /gene="Cblb"
                     /note="Cbl proto-oncogene B"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
     exon            1..144
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            145..330
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2979
                     /gene="Cblb"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase CBL-B; SH3-binding protein CBL-B;
                     signal transduction protein CBL-B; casitas B-lineage
                     lymphoma proto-oncogene b; RING-type E3 ubiquitin
                     transferase CBL-B; Casitas B-lineage lymphoma b; Cas-Br-M
                     (murine) ecotropic retroviral transforming sequence b; Cbl
                     proto-oncogene B, E3 ubiquitin protein ligase; Cbl
                     proto-oncogene, E3 ubiquitin protein ligase B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-B isoform 1"
                     /protein_id="NP_598285.2"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
                     /translation="MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRR
                     TVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLS
                     ENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAI
                     FPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKS
                     TIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY
                     STKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDG
                     RSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM
                     CTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLD
                     DDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVP
                     PRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPP
                     DSRLSRHFHHGEGVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSNL
                     NGRHSRMGSDQVLMRKHRRHDLPSEGAKVFSNGHLAPEEYDVPPRLSPPPPVTALLPS
                     IKCTGPIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHC
                     ILNGTHGTPSEMKKSNIPDLGIYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSS
                     SRPSSGQDLFLLPSDPFFDPASGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQ
                     APARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQN
                     NLEVARSILREFAFPPPVSPRLNL"
     misc_feature    265..663
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: 4H"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    664..882
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: EF-hand-like"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    883..1191
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: SH2-like"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    1006..1008
                     /gene="Cblb"
                     /note="Phosphoserine, by PKC/PRKCQ.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    1192..1278
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Linker"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    1249..1251
                     /gene="Cblb"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    1555..1926
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1588..1590
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1600..1602
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q3TTA7; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1612..1614
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q3TTA7; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1723..1725
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1735..1737
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1747..1749
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    1789..1863
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Interaction with VAV1. /evidence=ECO:0000250"
     misc_feature    2059..2061
                     /gene="Cblb"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    2152..2154
                     /gene="Cblb"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    2266..2337
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2284..2286
                     /gene="Cblb"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q13191; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    2473..2817
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2695..2697
                     /gene="Cblb"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q3TTA7; propagated from
                     UniProtKB/Swiss-Prot (Q8K4S7.1); phosphorylation site"
     misc_feature    2701..2811
                     /gene="Cblb"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4S7.1);
                     Region: Interaction with SH3KBP1. /evidence=ECO:0000250"
     misc_feature    2821..2943
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    2821..2943
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    order(2827..2832,2836..2844,2848..2853,2866..2868,
                     2878..2880)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     misc_feature    order(2827..2832,2836..2844,2848..2853,2866..2868,
                     2878..2880)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     exon            331..581
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            582..728
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..885
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1007
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1145
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1233
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1365
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1569
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1755
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2118
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2213
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2360
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2458
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2599
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2719
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..6315
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttagctc cgccccacgc cttggtctcc ggggatggct caggggtggg gtggccagtg
       61 agtggtctcc tcctccggcg ggcgctgcgg cggcctcccg agagtggcgc gggactgccg
      121 ggcgggcgtg gagctgtctg cacgaaagga ctaagattcc agatggcaaa ttctatgaat
      181 ggcagaaatc ctggtggtcg aggaggaaac ccccgcaaag gtcgaatttt ggggattatt
      241 gatgccattc aggatgcagt tggaccccca aagcaagctg cagctgaccg caggacagtg
      301 gagaagactt ggaaactcat ggacaaagtg gtaagactgt gccaaaatcc gaaacttcag
      361 ttgaaaaaca gcccaccata tatcctcgac attttacctg atacgtatca gcatttgcgg
      421 cttatattga gtaagtatga cgacaaccag aagctggctc aactgagcga gaatgagtac
      481 tttaaaatct acatcgacag tctcatgaag aagtcaaagc gagcgatccg gctcttcaaa
      541 gaaggcaagg agaggatgta cgaggagcag tcgcaggaca gacggaatct cacaaagctg
      601 tcccttatct tcagtcacat gctggcagaa atcaaggcga tctttcccaa tggccagttc
      661 cagggagata acttccggat caccaaagca gatgctgccg aattctggag gaagtttttt
      721 ggagacaaaa ctatcgtacc atggaaagtc ttcagacagt gcctgcatga ggtccatcag
      781 atcagctctg gcctggaggc catggctctg aagtcaacca ttgacttaac ttgtaatgat
      841 tacatctccg tgtttgaatt tgatattttt accaggctat ttcagccctg gggctctatt
      901 ttacggaatt ggaacttctt agctgtgaca cacccggggt acatggcatt tctcacatat
      961 gatgaagtta aagctcgact acagaaatac agcaccaagc ctggaagcta cattttccgg
     1021 ttaagctgca ctcggctggg acaatgggcc attggctatg tgactgggga cggcaatatc
     1081 ctacagacca tacctcataa taagcccctg ttccaagccc tgattgatgg tagcagggaa
     1141 ggcttttacc tttatccaga tggacgaagc tataaccctg atttaaccgg attatgtgaa
     1201 cctacacctc atgatcatat aaaagttaca caggagcaat atgaactgta ttgtgaaatg
     1261 ggctccactt ttcagctgtg caagatctgt gcagagaatg acaaagatgt caagatcgag
     1321 ccttgcgggc atctcatgtg cacttcgtgc cttaccgcgt ggcaggagtc tgatggccaa
     1381 ggctgcccct tctgtcgctg tgagataaaa ggaaccgaac ctatcatcgt ggatcccttt
     1441 gaccccagag acgaaggctc caggtgctgc agcatcatcg accctttcag catccccatg
     1501 ctcgacttgg atgatgacga tgatcgagag gagtctctga tgatgaaccg gctggcgagt
     1561 gttcgcaagt gcacagacag gcagaactcg ccagtcacat cgccaggatc ctcacccctt
     1621 gcccagagaa gaaagcctca gccagaccct ctccagatcc cccacctcag cctgccacca
     1681 gtgcctcccc gcctggacct cattcagaaa ggcatcgtgc gctctccctg tggcagcccc
     1741 acgggctccc cgaagtcttc tccatgcatg gttagaaaac aagacaaacc actcccagca
     1801 ccccctcctc ccttgcgaga tcctccgcct ccaccagagc ggcctccgcc aatcccgcct
     1861 gacagtagac tgagcagaca cttccaccac ggagagggtg tgccttccag ggaccagcca
     1921 atgcctcttg aagcctggtg ccctcgggat gccttcggga ctaatcaggt gatgggatgt
     1981 cgcatcctag gggatggctc tccaaagcct ggcgtcacag caaactccaa cttaaatgga
     2041 cgtcacagtc gaatgggctc tgaccaggtt cttatgagga aacacagacg ccacgatttg
     2101 ccttcagaag gcgccaaggt cttttccaat ggacaccttg cccctgaaga atacgacgtt
     2161 cctcctcggc tttcccctcc tcctccagtc actgcccttc tccctagcat aaagtgtact
     2221 ggtccaatag caaattgtct ctccgagaaa acaagagaca cagtagaaga agatgatgat
     2281 gaatacaaga ttccttcatc ccatcctgtt tccctgaatt cacaaccatc tcattgtcat
     2341 aatgtcaaac ctcctgttcg gtcttgtgat aatggtcact gtatactgaa tggaactcat
     2401 ggtacgcctt cagagatgaa gaaatcaaac atcccagatt taggcatcta tttgaagggt
     2461 gaagatgctt ttgatgccct ccccccatcc cttcctcctc ctccacctcc tgcaagacat
     2521 agtctcatcg agcattcaaa acctccaggc tccagtagcc ggccttcctc aggacaggac
     2581 cttttccttc ttccttcaga tccctttttt gacccagcaa gtggccaagt tccattgcct
     2641 ccggccagga gagcaccagg agatggtgtc aaatccaaca gagcctccca ggactatgac
     2701 cagctccctt catcttccga tggttcgcaa gcaccagcta gaccccccaa accacgaccc
     2761 cgaaggactg caccagaaat tcatcacaga aagccccatg ggcccgaggc ggcactggaa
     2821 aatgtggatg cgaaaattgc aaaactcatg ggagaggggt atgcctttga agaggtgaag
     2881 agagccttag agatcgccca gaataacctg gaagtggcca ggagcatact tcgagaattc
     2941 gccttccctc ctcccgtctc gccacgtctc aatctatagc agcccagact gcaaacacca
     3001 aagggtaaaa cagttaacaa atattccagg agtatgggac ggaaggactg agagggaatg
     3061 caggagccat ggtgtctttt catgtggcgt ctccagaagg cagccttgag tccagcttct
     3121 ctggtaccac agctccctga ggatgcccac gctgcagctt ctgtgtttgt gctagccata
     3181 cttttaaatc agggttgaac tgagaaaata atttaaagac gtttactccc ccttgaactt
     3241 tgaatctgtg aaatgctttc cttgtttaca cgttggcaga attgcagttt gtctctgttt
     3301 ttgattcctg tactgtgttc ctgacaggcc cttggcagag ttggtcaggt ctgctgtaag
     3361 tttgtccatg cccaccctgc tgcccacatt ggcagctaaa gcatctcttc gtgttgctgt
     3421 ctatccgggc cccacctcat gtgtccacgt ccagttcatt tctctcattc acacagcatg
     3481 ctagtctgag gtcctgattt ttcatcgttt taaactaatg cagaaagaaa aagaaaaaga
     3541 aaaaaaatgt atgtggtctg gtcttcacta ctgagtctct tctttgggaa ccatcactgt
     3601 tgagaggtgg ggaaacctga atgtaaaaag catttatttg tcaataaact gccttttgta
     3661 aggggttttt atatactgta aaagagcttc ccttgttagt ttaagttctg tgacctttag
     3721 gtttctgtac actccctccc gtccgcccag gagtgccatg acagatgcag gagaaaatgg
     3781 ggcagcgccc gtactacagg accgtaatga gattctctga tagttatgcc tccatcactt
     3841 tcaggagaga tggaaagggg ggccaccgcc tcgaaatatg ttaatatgcc tttagataag
     3901 gtcatagaca tacatgcctt tcccaagtgg aagagagccc cttttctatg ttatgacatc
     3961 accctggctc ctccctgtgt gggagcccct aaggcactga tgactgttat gtatcactgc
     4021 tactgcaggc cttcttactt gcaaaactct tcgtaccctt tctccagtca ggttaggagt
     4081 cccgtttact ctgtgggttt tctcattgac tgctccgtgt tgcccgtccc agtcagatga
     4141 aaccgtggta tcactttaaa tctacagata ccccttgacc atctgtaaag tgctttgcac
     4201 tcttgttggc tttgaaagca caaaatttca cacatgaact ccgccatatt atttgtgtat
     4261 atgtgtttgg tggtaaatgt ctccaatctg atggatgaat cctctgagac tgatgcgagg
     4321 acttttagac cttcagattg cttttgtttt gttttgtttt gttttgtttt gttttttgca
     4381 tccctaatag tgtgtgaggg gaaataaaag ccatctccat gcaaaaatgc ttgcacgaca
     4441 ttttgatagt ttctaaagat ggattcagtt gtaggttgca tgggtgtctc ttacccctcc
     4501 ttactccaca cccagagatg cctcagataa tcactccctc atcctgacaa aggacaagat
     4561 actacagcag atagatccga tgcagctgcc attttatgag agtcatgtcc acagctgtgt
     4621 ttgcccagaa aggggaacgt gcccagcata ctcgtttgca gtgtggcttt catgggatga
     4681 gacaggactt gaggatcaca gtctttgcat atgtcaggtt tgttcagagg gccctatgtt
     4741 tcttctgcta ccacaggggg attttttaat gtttttacat cctatacctg ggaggaggta
     4801 tgaatacaag gttttttttt aatatacttt ttacaattgg ctctttgttg ttttattatc
     4861 tgctcttaat tttttttact tgttttataa gttctgatgt catactgata gataacagtg
     4921 ctatgttttt tggggggttt cacacaactt gccaacaatc ggcatagcct aaaacccaaa
     4981 gtttgcccct tcgttgtcct aacactgtta aacatcctta aactacgagg gggttggttt
     5041 acaacaggag cactgggacc cacagcatat tctcctgcac tctcgcataa cacaagagat
     5101 ttccgtcaag aatttaaagg ctaaagatgt gctcaaacag ttgatttgga cctgaggttt
     5161 agggagggag ggaagtgtaa ataattttct ggattgtacc aagatctctg ctgcatccac
     5221 acagtagcca ctgccggttt tctcatcaag aaaagtgaac cttgtgactc atacggaaga
     5281 cagagcaaac agaaagcata aagactcaca gaatttgttt gagaacagta gttcaaactc
     5341 tttttcatta ggaaagggac tactagttaa tactttgaaa tgtcccatac tttgttccct
     5401 ctttttccag aaattgagat gtgcctccca atgctcaaga tttgataata gaattaccct
     5461 taagccagta tttaatataa tctacacaat taaaacaaac cacggctaat tggaacctct
     5521 gcccgggatc tatccccaat gatattccag tcgtggtttt tccagaattc tggaggattt
     5581 ttttcctatt tccttttcct tttaacccac cacacctaca cccccacccc aacccataac
     5641 cccacatccg aaccaccacc aacttcttgg tatctgatct atcacagcca aattttctgg
     5701 acccagatcc caacattttg atgcttaact taatcttgca cccacaatta aaattattag
     5761 cccttttcta ccttccctct gcccacagta caacacagag ccctagccag agcctccaga
     5821 ggtctgtttg ctaactcagt atttcgcaca cccaaggaca catgcaaaga gttcttcata
     5881 atgtgaactt tctaattgtt cagttccaga agcatttcct gcagtttgaa cgtgactttg
     5941 cctctcggat tttcaacttg aagctttagt ttgcactgaa ttatttcatc tggttttaaa
     6001 atgtctcaaa tggactgatt tggaaacaaa atgtggtata ttttaaatat tgatggaggt
     6061 actttctgta aacctgaaat gttagagctc cgaggaagac tttccggaaa aagacagcaa
     6121 tagaaagaaa gttttcttct cagttcctat ttttattgtt tttgaaatgc attttttaaa
     6181 aacttgtcta atgtggcaaa atagctatgt gatcaattaa tttatatttt attcattctt
     6241 tttcaattct ggatatgtaa cctcaagtac tttatctgtt cttttaaggt attttataaa
     6301 atgaatgttg acaaa
//
LOCUS       NM_053655               4936 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 1,
            mRNA.
ACCESSION   NM_053655
VERSION     NM_053655.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4936)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4936)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4936)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4936)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4936)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4936)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4936)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4936)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4936)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4936)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_053655.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085843.1, SRR26643297.39009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-384             JAXUCZ010000011.1  98101064-98101211
            385-431             JAXUCZ010000011.1  98105694-98105740
            432-503             JAXUCZ010000011.1  98106090-98106161
            504-590             JAXUCZ010000011.1  98108322-98108408
            591-753             JAXUCZ010000011.1  98109928-98110090
            754-874             JAXUCZ010000011.1  98113029-98113149
            875-1006            JAXUCZ010000011.1  98115531-98115662
            1007-1213           JAXUCZ010000011.1  98117537-98117743
            1214-1334           JAXUCZ010000011.1  98123938-98124058
            1335-1490           JAXUCZ010000011.1  98124251-98124406
            1491-1580           JAXUCZ010000011.1  98124558-98124647
            1581-1673           JAXUCZ010000011.1  98126328-98126420
            1674-1730           JAXUCZ010000011.1  98128415-98128471
            1731-1763           JAXUCZ010000011.1  98129443-98129475
            1764-1958           JAXUCZ010000011.1  98131039-98131233
            1959-2068           JAXUCZ010000011.1  98131384-98131493
            2069-2228           JAXUCZ010000011.1  98133415-98133574
            2229-4936           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4936
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2285
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 1"
                     /protein_id="NP_446107.2"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYT
                     DFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPK
                     DIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLD
                     LMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSL
                     ANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLL
                     QLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDI
                     LTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYS
                     TQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLM
                     NNNIEEQRRNRLARELPSAVSRDKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTT
                     GNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDC
                     EVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTE
                     SEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1040
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1040
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,570..572,
                     780..782,786..791,867..881,888..890)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,570..572,
                     780..782,786..791,867..881,888..890)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,582..584,621..623,696..698,702..704,
                     708..719,723..728,789..791,795..806,876..884)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,582..584,621..623,696..698,702..704,
                     708..719,723..728,789..791,795..806,876..884)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    570..581
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    570..581
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(576..581,669..674)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(576..581,669..674)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    777..788
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    777..788
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    807..1664
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    807..1664
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    867..875
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    867..875
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1992..2264
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1992..2264
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..384
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..431
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..503
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..590
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..753
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..874
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1006
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1213
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1334
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1490
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1580
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1673
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1730
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1763
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1958
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2068
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2228
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..4936
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggagttg aagcagaaga atggggtaaa tttcttcaca
      421 ccaaaaacaa gctttacaca gattttgatg aaattcgaca agaaattgaa aatgaaactg
      481 aaagaatttc aggaaataat aagggagtaa gccctgagcc aatccatctc aaggttttct
      541 cgcccaacgt tgtcaacctg acgcttgtgg atttaccagg aatgaccaaa gtacctgtag
      601 gtgatcagcc caaggatatt gagcttcaaa tcagagaact tattcttcgg ttcatcagta
      661 atcccaattc cattatcctt gctgtcactg ctgcaaatac agatatggca acgtcagagg
      721 cacttaagat ttccagagag gtagatccag atgggcgcag aactctagct gtaatcacca
      781 agcttgatct catggatgcg ggtactgatg ccatggatgt attgatggga agggttattc
      841 cagtcaagct tggaataatt ggagtagtta acaggagcca actggacatt aacaataaga
      901 agagtgtaac tgattcaatc cgtgatgagt atgcttttct tcaaaagaag tacccatctc
      961 tggccaacag aaatggaaca aagtatcttg ctaggactct gaataggtta cttatgcatc
     1021 atatcagaga ctgtttacca gagctgaaaa caagaataaa tgtcttagct gctcagtatc
     1081 agtctcttct aaatagctat ggtgagcccg tggatgataa aagtgctact ttactccagc
     1141 tcattaccaa gtttgccaca gagtattgta acactattga aggaacggca aagtacattg
     1201 aaacttctga gctatgtggt ggtgctagga tttgttatat tttccatgag acttttgggc
     1261 gaaccttaga atctgttgat ccactaggtg gccttaacac tattgacatc ttgaccgcca
     1321 ttagaaatgc tactggcccc cgtccagctt tatttgtgcc tgaagtttca tttgagttac
     1381 tggtcaaacg tcagattaag cgtctagagg agcccagcct ccgctgtgtg gagctggtcc
     1441 acgaggaaat gcagaggatc attcagcact gtagcaacta cagcacacag gaactgttac
     1501 ggttccctaa actccatgat gccatagttg aagtagtgac ttgtcttctt cgtaaaaggt
     1561 tgcccgtgac aaatgaaatg gtacataact tagtggcaat tgagctagca tatatcaaca
     1621 caaaacaccc cgactttgct gatgcctgtg ggctaatgaa caataacata gaggaacaaa
     1681 gaagaaacag actagcaaga gaactacctt ccgctgtatc gcgagacaag ttaattcagg
     1741 acaacagaag agaaactaaa aatgttgcat ctgcaggtgg tggaattgga gatggtggtc
     1801 gaattggaga tggtggtcag gaaccgacaa caggcaactg gagaggaatg ctgaaaactt
     1861 caaaagctga agaattactt gctgaagaaa aatcaaaacc aattccaatt atgccagcaa
     1921 gtccacaaaa aggccatgct gtcaatttgc tagatgtgcc agttccagtt gcacgaaaac
     1981 tgtctgcccg agaacagcga gattgtgagg ttattgaaag actcatcaaa tcatattttc
     2041 taattgtcag aaagaatatt caagacagcg tcccaaaggc agtaatgcat tttttggtta
     2101 atcatgtgaa agatactctt cagagtgaat tagtagggca gctgtataag tcatccttat
     2161 tagatgacct tctgactgaa tccgaggaca tggcacagcg aagaaaagaa gcggctgaca
     2221 tgctgaaggc attacaagga gccagtcaaa ttattgctga aatccgagag actcatcttt
     2281 ggtgaacaga actgtttggt cttctacact ttgctgactt gaacctacta gctactgcct
     2341 acctgagtag aaatttattt atggactttt gtgtatcgca gtgtatgaat ttgcttgtgt
     2401 gaagactggc tataagctga aaagtatatt attcattaca agacaaatca catgtttaat
     2461 tcacattttt caagtttcct atgatgtata tcaagtctgt ccgtttcagt caaacttaca
     2521 agaacaattg atgttctagt tgtacaaagc agtttgcctg tgcatatgat gacctgcgta
     2581 accttttttt agtcttaaag ctgcagccgt agtcctcaaa gaggaagctc caggacattt
     2641 catgactata atgcatgcac tatttatata gactgacctg gcttcaaaag gtggagcctg
     2701 gcgagttcct cacataatca atgtatccac ctatccttca tttttatagt cttaaaaaac
     2761 aaacaaaatt ctgaaacttc tgcagtttta ggaaaaatat aagatctgaa agactcataa
     2821 agatgtagga acagactgtg taattaatgg ctcctgagtc tatactgccc taatgttaga
     2881 aagtaaaata tgctttgatt caaaataagc ctgaaaatat aaattgactt cctgcattaa
     2941 aaataactat taggaacttt cttagtaaca ataactggtc ctgttagttt ctaaatgact
     3001 cagtgacaac ctaaatttcc ctaatttaca agtacatcga ttgcagtcca gatgcacctt
     3061 agggtggggc gctgactctg ggctccgaga ctcagttatg tgagacctaa aagtctactc
     3121 tgtatccact ggtaatgcta ctttatagtt ccacaccaac agaatacatt tgtcaaagaa
     3181 aaatacctgg acatacacat acacctaaaa gcttatggac tactaaactg tattcagggg
     3241 ttgaggattt acaacctatt ttgtgaaaac tgcctgtgca attcaatttc tgacctagct
     3301 gggcagtggt ggtgcacacc tttaatccca gcttttggga ggcagaggca ggtggatctc
     3361 tgagttcaag gccagcctgg tctacagagt tgagttccaa gacaaccaga actacacaga
     3421 gaaaccctgt cttgaacccc cctcccccca aaaaattgaa acctaaatag aaatctttga
     3481 tgtatctagt tttctctgac caaatgatac atttgtgtta taaatactaa aattcttttc
     3541 aggtcaggca tcttatgaaa tactattagc aaggaaaaca agaacatgtt atctttagtt
     3601 tagatgccca ttgaaccatc tcaaaaacaa aggcagtctg ataacagtac cagcttgaca
     3661 gtgagtatac actgcctaaa tgtgttagca tacttaagaa aaatatcctg ttatctaact
     3721 attaggtatc catggtttat tttttaagag agatgaccac cactgtagcc ttttgaattt
     3781 gtaaagagaa agaatgcacc tttatccaac atttcaaata gattttaaaa ggaagatgtt
     3841 agctttaaaa acgtgctatg ataatgtact tgttagcact acacactttg tacaaagaaa
     3901 aacaagcaag aaaggtaggg aaatgaaagc ttcctttgtg tacttttaca ctaagctgtg
     3961 ttctgaaaca tggagataat ttataagacc actgtatgtt ctatgtaaat aaaaatgctg
     4021 gtgtgaaatg gcattacggt ttgccagtaa gtgaattctt cctgacttgc cgtaagagag
     4081 aggtttaaat aggtgcatct ttgaaatatc tgaatctact tcataatgga acgatttaaa
     4141 ttgtactgca ccaaaagttt tatgccattt ttttaattag ataatcacca ccaaggcctt
     4201 gttacatctt tgtgtctaca gatgaagaca gaaacttctt ccaagtaatc caaggatgaa
     4261 tgctgagaac atgaactttg ctgcaagacg tctagaagct gatccacagt ttatgtttca
     4321 cccctatgta cattggggtg gtgctatctt gatttttaca gaaactgttt ttgagaatta
     4381 gcttgccttg tgtatacaaa cctgaactag tttgacttca aaacttcctg tatcttttct
     4441 gttcttactg actgcatact tgatgagata ctttttgttt ctttggtttc ttaaaatatc
     4501 tgctatagga acccactggc aaaaataggc agttatcagt aaattattga aacacagaac
     4561 aaggaagtgg aaaactgaac tataaatgaa gtctggtact gattgatgtt ttgttttaag
     4621 aaaaaactat tttgtactac agtttctatt gggaaccact gccatatcta actccttttt
     4681 aagaattctg tttgcttggc agcatcaatc agaagtttaa ctttgtaaca gatttctcac
     4741 atctaaacag acattagaag cttggccagt ttgtacagct atgtaacaca actgcaatca
     4801 ggtgcttacc ttacctcctg tgttaacttt atacagtcat ttccactgca ccacttcttc
     4861 agaccaagga gcaagaaaga tcattcttgc ataaagaaat gaactataat taaatatcac
     4921 tttattttga aatgca
//
LOCUS       NM_001437794            1043 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family A, member 3 (Bpifa3),
            transcript variant 2, mRNA.
ACCESSION   NM_001437794 XM_039105883
VERSION     NM_001437794.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039105883.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.528124.1,
                                           SRR26360181.303831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000003.1  163069924-163070251
            329-479             JAXUCZ010000003.1  163073784-163073934
            480-587             JAXUCZ010000003.1  163075743-163075850
            588-737             JAXUCZ010000003.1  163077544-163077693
            738-822             JAXUCZ010000003.1  163078635-163078719
            823-1043            JAXUCZ010000003.1  163079636-163079856
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1043
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI fold containing family A, member 3"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
     exon            1..328
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="upstream in-frame stop codon"
     CDS             202..1032
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="BPI fold-containing family A member 3 isoform 2
                     precursor"
                     /protein_id="NP_001424723.1"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
                     /translation="MHLLWRFLVLLLGLLALPSALPKQPWPGLTKAHKDGRSTLARII
                     AQGLLKHNAEGRIQSMRLLDRLNVSGTVAPGMVSWLISGMNFQQQQEISINITNVQLD
                     CGGIQMAFPKEWFSANITLEFDIEFKLPFNSNILKTHAQMGLAAESWLEKDEFGRRKL
                     VTGRCQMEPSSDSASMTTEAASPKMKNFLHNLRESLGKVIPNLVESQNRWLLITLVSP
                     ESVKSLLSGSRGLPLPAIGQKEVLLVEILRLSQCVASAVPWKNDPQVPRHPVLSNNKL
                     "
     sig_peptide     202..261
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    340..822
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     misc_feature    340..822
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     exon            329..479
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..587
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..737
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..822
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1043
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccaat gtgagctagc cctgggagca gctgccagag ccatttgtac cacctcccac
       61 agcatgctgg gggcagccgt gcagccacct gccggaagac agctgtaagc ccatcgatct
      121 gggtggccat actcacagcc aactgcctgg gccctgctgg accattactg acacctgcag
      181 gttcgggtgc cagcacttga gatgcaccta ctctggaggt tcctggtcct cctcctggga
      241 ttactagcct tgccctcagc cctgcccaag cagccttggc ctggactgac caaggcccac
      301 aaggatggcc ggtccaccct agcgagaatt attgcacagg gcctcctgaa gcacaatgca
      361 gaaggacgaa tccagagcat gcgtcttctg gaccgtctga acgtctcagg gacagtggcc
      421 ccagggatgg tgagctggct tattagtggc atgaacttcc agcagcagca agaaatcagt
      481 atcaacatta ccaatgtgca gctggactgt ggcgggatcc agatggcttt ccccaaagag
      541 tggttctccg caaacatcac acttgaattt gacattgaat tcaaactgcc cttcaattcg
      601 aatatcctca aaacccatgc ccagatgggc ctcgctgcag agtcctggct ggagaaagat
      661 gagttcggac ggaggaagct ggtgacaggc aggtgccaaa tggagcccag cagtgacagt
      721 gcatccatga ccactgaggc agcctcaccc aagatgaaga attttctcca caacctcaga
      781 gaaagcctgg ggaaagttat cccgaatttg gtagaaagtc aaaacaggtg gctgctcata
      841 accttggtca gccctgaatc agtcaaatct ctgctatcag gctcgagggg cctcccattg
      901 cctgccattg gtcaaaagga ggtacttctg gttgagatct tacgtctctc tcagtgtgtg
      961 gcttctgctg tcccctggaa aaatgacccc caggtcccaa gacatcctgt cctttccaac
     1021 aataaactct aactctgaag gat
//
LOCUS       NM_001437711            2020 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus COP9 signalosome subunit 7B (Cops7b), transcript
            variant 2, mRNA.
ACCESSION   NM_001437711
VERSION     NM_001437711.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.118827.1,
                                           SRR26360190.1938088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000009.1  94686329-94686475
            148-325             JAXUCZ010000009.1  94693686-94693863
            326-401             JAXUCZ010000009.1  94697608-94697683
            402-490             JAXUCZ010000009.1  94702271-94702359
            491-693             JAXUCZ010000009.1  94705054-94705256
            694-799             JAXUCZ010000009.1  94706847-94706952
            800-2020            JAXUCZ010000009.1  94710439-94711659
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2020
                     /gene="Cops7b"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
     exon            1..147
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    146..148
                     /gene="Cops7b"
                     /note="upstream in-frame stop codon"
     exon            148..325
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..958
                     /gene="Cops7b"
                     /note="COP9 (constitutive photomorphogenic) homolog,
                     subunit 7b; COP9 constitutive photomorphogenic homolog
                     subunit 7B"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b"
                     /protein_id="NP_001424640.1"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFG
                     ELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSAAQQNKLKHLTIV
                     SLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGR
                     DIQKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKK
                     TLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH"
     misc_feature    425..694
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    425..694
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    659..808
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     misc_feature    659..808
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     exon            326..401
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            402..490
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            491..693
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            694..799
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            800..2020
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcatatgt ggactccttc tatggggttg gtttctgaat cctgttactt gaaacccagc
       61 aggaagatcc acttttaccc cggagacatg acagcccacc gacagttaac ttctgtttac
      121 atggaactca ggagtctgca aatcatgatc tcaagaccag agaatggcag gtgaacagaa
      181 accctcaagt aacctcttgg agcagtttat tttattagcc aaaggcacca gcggctcagc
      241 cctcaccact ctcataagcc aggtactgga ggctcctgga gtttatgttt ttggagaact
      301 actggagttg gccaatgttc aggagcttgc agaaggagct aatgctgcat atttgcagtt
      361 gctgaacctg tttgcctatg gtacataccc ggattacata gccaacaagg agagcctgcc
      421 agaactgagc gcagcccagc agaacaagct gaagcatctt accatcgtga gtttggcatc
      481 aagaatgaag tgtatcccct actctgtgct gctgaaggac ctggagatga ggaatctccg
      541 ggaactagaa gaccttatca ttgaggctgt ctacactgac atcatccagg gcaagctgga
      601 ccagcgaaac cagctcctgg aagtggattt ctgcattggc cgtgacatcc agaagaaaga
      661 tatcaataat attgtcaaga ccttgcatga atggtgtgac ggctgtgagg cagttctcct
      721 gggcattgag cagcaagttc tgagagccaa ccagtacaaa gagaaccacc accggactca
      781 gcagcaggtg gaagccgagg ttagcaacat taagaagaca ctcaaagcaa cagcgtcctc
      841 ctcagctcag gaaatggagc agcaactggc tgaacgggag tgtccccccc atactgagca
      901 gaggcaaccc actaagaaga tgtccaaagt gaaaggtctg gtctccagcc gccactaggg
      961 ccggctgggg cagctggcac tcagcaggcc tgggtcaggt gggaggggac acccagggcc
     1021 tatttcctcc cctctctaac tgcagtgagt tccagatctg cccgcccctc accagtacct
     1081 ccccatccat tggtaccatt tcggaaaatg attgctcctc ccttgcctcc tttcctagtt
     1141 gttcccttca gactcagggg ctcaacggat gccatcctaa cagggtccaa cactgcctgg
     1201 cttccctgca gggtccttgt ctctgtgatg ggctacctcc ctcccagttg ttcttttgcc
     1261 cctgtcattt tgtcaggctg gtcctaagct ggaggcagtt tccccagccc tgagggatga
     1321 ctgtggaggt ggctcctctc tgagtgaaga gggggccttg cttctccagc ctcgtgtacc
     1381 acagtaccca caatggtgca agtgtctcta gccaggtagc cacattgttt ccctctcctg
     1441 ccttacccct gttggcagtg ccagtgcagg ccatggaggg atgtggtgct gggctatgtt
     1501 tactaaacct ttgggttttc agcctcttaa gcccagccag gatctctcat cgagttgagg
     1561 cactaggctg actaacctct ggtgtctgat accagtgggg ggtgcttggg tctgtgggcg
     1621 gcagaaggcg tttctcctag cttggtgtcc tctgctgact gctcttcctg ctgcctctga
     1681 ctgctcagcc ttgatttggc atttaggctg cccactgccc actgggattg tctggcaaca
     1741 tttgctctcc caagatcttt catgcctcct ggctgcccct ggggtaggag tggtggtgcc
     1801 gaagcccctc agactggtga aggaccattg ctgcttcttt ctccttcctt cccacccctc
     1861 cttggctggc aacccagaac cctctgataa catcatactc cactcctggc cagagaaaag
     1921 gacttgacta gactttctga acttgaacag tttcaggtta tattttaatt tttttttgta
     1981 caggttgatt ctaatacatt tcaacatgct tttttctccc
//
LOCUS       NM_001437691            4960 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 11,
            mRNA.
ACCESSION   NM_001437691 XM_039087897
VERSION     NM_001437691.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4960)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4960)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4960)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4960)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4960)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4960)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4960)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4960)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4960)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4960)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087897.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132727.1, SRR26643296.30241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-441             JAXUCZ010000011.1  98104416-98104454
            442-488             JAXUCZ010000011.1  98105694-98105740
            489-560             JAXUCZ010000011.1  98106090-98106161
            561-647             JAXUCZ010000011.1  98108322-98108408
            648-810             JAXUCZ010000011.1  98109928-98110090
            811-931             JAXUCZ010000011.1  98113029-98113149
            932-1063            JAXUCZ010000011.1  98115531-98115662
            1064-1270           JAXUCZ010000011.1  98117537-98117743
            1271-1391           JAXUCZ010000011.1  98123938-98124058
            1392-1547           JAXUCZ010000011.1  98124251-98124406
            1548-1637           JAXUCZ010000011.1  98124558-98124647
            1638-1730           JAXUCZ010000011.1  98126328-98126420
            1731-1787           JAXUCZ010000011.1  98128415-98128471
            1788-1982           JAXUCZ010000011.1  98131039-98131233
            1983-2092           JAXUCZ010000011.1  98131384-98131493
            2093-2252           JAXUCZ010000011.1  98133415-98133574
            2253-4960           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4960
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2309
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 11 is encoded by transcript variant 11;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 11"
                     /protein_id="NP_001424620.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSK
                     GVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVN
                     LTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKI
                     SREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKS
                     VTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY
                     QSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHET
                     FGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRC
                     VELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAI
                     ELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKVASAGGGIGDGGRIG
                     DGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKL
                     SAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSS
                     LLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2016..2288
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2016..2288
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..488
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..560
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..810
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1063
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1547
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1637
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1730
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1787
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1982
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2092
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2252
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..4960
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gaaccctgct acatggaaaa
      421 actcaagaca cctttctaaa ggagttgaag cagaagaatg gggtaaattt cttcacacca
      481 aaaacaagct ttacacagat tttgatgaaa ttcgacaaga aattgaaaat gaaactgaaa
      541 gaatttcagg aaataataag ggagtaagcc ctgagccaat ccatctcaag gttttctcgc
      601 ccaacgttgt caacctgacg cttgtggatt taccaggaat gaccaaagta cctgtaggtg
      661 atcagcccaa ggatattgag cttcaaatca gagaacttat tcttcggttc atcagtaatc
      721 ccaattccat tatccttgct gtcactgctg caaatacaga tatggcaacg tcagaggcac
      781 ttaagatttc cagagaggta gatccagatg ggcgcagaac tctagctgta atcaccaagc
      841 ttgatctcat ggatgcgggt actgatgcca tggatgtatt gatgggaagg gttattccag
      901 tcaagcttgg aataattgga gtagttaaca ggagccaact ggacattaac aataagaaga
      961 gtgtaactga ttcaatccgt gatgagtatg cttttcttca aaagaagtac ccatctctgg
     1021 ccaacagaaa tggaacaaag tatcttgcta ggactctgaa taggttactt atgcatcata
     1081 tcagagactg tttaccagag ctgaaaacaa gaataaatgt cttagctgct cagtatcagt
     1141 ctcttctaaa tagctatggt gagcccgtgg atgataaaag tgctacttta ctccagctca
     1201 ttaccaagtt tgccacagag tattgtaaca ctattgaagg aacggcaaag tacattgaaa
     1261 cttctgagct atgtggtggt gctaggattt gttatatttt ccatgagact tttgggcgaa
     1321 ccttagaatc tgttgatcca ctaggtggcc ttaacactat tgacatcttg accgccatta
     1381 gaaatgctac tggcccccgt ccagctttat ttgtgcctga agtttcattt gagttactgg
     1441 tcaaacgtca gattaagcgt ctagaggagc ccagcctccg ctgtgtggag ctggtccacg
     1501 aggaaatgca gaggatcatt cagcactgta gcaactacag cacacaggaa ctgttacggt
     1561 tccctaaact ccatgatgcc atagttgaag tagtgacttg tcttcttcgt aaaaggttgc
     1621 ccgtgacaaa tgaaatggta cataacttag tggcaattga gctagcatat atcaacacaa
     1681 aacaccccga ctttgctgat gcctgtgggc taatgaacaa taacatagag gaacaaagaa
     1741 gaaacagact agcaagagaa ctaccttccg ctgtatcgcg agacaaggtt gcatctgcag
     1801 gtggtggaat tggagatggt ggtcgaattg gagatggtgg tcaggaaccg acaacaggca
     1861 actggagagg aatgctgaaa acttcaaaag ctgaagaatt acttgctgaa gaaaaatcaa
     1921 aaccaattcc aattatgcca gcaagtccac aaaaaggcca tgctgtcaat ttgctagatg
     1981 tgccagttcc agttgcacga aaactgtctg cccgagaaca gcgagattgt gaggttattg
     2041 aaagactcat caaatcatat tttctaattg tcagaaagaa tattcaagac agcgtcccaa
     2101 aggcagtaat gcattttttg gttaatcatg tgaaagatac tcttcagagt gaattagtag
     2161 ggcagctgta taagtcatcc ttattagatg accttctgac tgaatccgag gacatggcac
     2221 agcgaagaaa agaagcggct gacatgctga aggcattaca aggagccagt caaattattg
     2281 ctgaaatccg agagactcat ctttggtgaa cagaactgtt tggtcttcta cactttgctg
     2341 acttgaacct actagctact gcctacctga gtagaaattt atttatggac ttttgtgtat
     2401 cgcagtgtat gaatttgctt gtgtgaagac tggctataag ctgaaaagta tattattcat
     2461 tacaagacaa atcacatgtt taattcacat ttttcaagtt tcctatgatg tatatcaagt
     2521 ctgtccgttt cagtcaaact tacaagaaca attgatgttc tagttgtaca aagcagtttg
     2581 cctgtgcata tgatgacctg cgtaaccttt ttttagtctt aaagctgcag ccgtagtcct
     2641 caaagaggaa gctccaggac atttcatgac tataatgcat gcactattta tatagactga
     2701 cctggcttca aaaggtggag cctggcgagt tcctcacata atcaatgtat ccacctatcc
     2761 ttcattttta tagtcttaaa aaacaaacaa aattctgaaa cttctgcagt tttaggaaaa
     2821 atataagatc tgaaagactc ataaagatgt aggaacagac tgtgtaatta atggctcctg
     2881 agtctatact gccctaatgt tagaaagtaa aatatgcttt gattcaaaat aagcctgaaa
     2941 atataaattg acttcctgca ttaaaaataa ctattaggaa ctttcttagt aacaataact
     3001 ggtcctgtta gtttctaaat gactcagtga caacctaaat ttccctaatt tacaagtaca
     3061 tcgattgcag tccagatgca ccttagggtg gggcgctgac tctgggctcc gagactcagt
     3121 tatgtgagac ctaaaagtct actctgtatc cactggtaat gctactttat agttccacac
     3181 caacagaata catttgtcaa agaaaaatac ctggacatac acatacacct aaaagcttat
     3241 ggactactaa actgtattca ggggttgagg atttacaacc tattttgtga aaactgcctg
     3301 tgcaattcaa tttctgacct agctgggcag tggtggtgca cacctttaat cccagctttt
     3361 gggaggcaga ggcaggtgga tctctgagtt caaggccagc ctggtctaca gagttgagtt
     3421 ccaagacaac cagaactaca cagagaaacc ctgtcttgaa cccccctccc cccaaaaaat
     3481 tgaaacctaa atagaaatct ttgatgtatc tagttttctc tgaccaaatg atacatttgt
     3541 gttataaata ctaaaattct tttcaggtca ggcatcttat gaaatactat tagcaaggaa
     3601 aacaagaaca tgttatcttt agtttagatg cccattgaac catctcaaaa acaaaggcag
     3661 tctgataaca gtaccagctt gacagtgagt atacactgcc taaatgtgtt agcatactta
     3721 agaaaaatat cctgttatct aactattagg tatccatggt ttatttttta agagagatga
     3781 ccaccactgt agccttttga atttgtaaag agaaagaatg cacctttatc caacatttca
     3841 aatagatttt aaaaggaaga tgttagcttt aaaaacgtgc tatgataatg tacttgttag
     3901 cactacacac tttgtacaaa gaaaaacaag caagaaaggt agggaaatga aagcttcctt
     3961 tgtgtacttt tacactaagc tgtgttctga aacatggaga taatttataa gaccactgta
     4021 tgttctatgt aaataaaaat gctggtgtga aatggcatta cggtttgcca gtaagtgaat
     4081 tcttcctgac ttgccgtaag agagaggttt aaataggtgc atctttgaaa tatctgaatc
     4141 tacttcataa tggaacgatt taaattgtac tgcaccaaaa gttttatgcc atttttttaa
     4201 ttagataatc accaccaagg ccttgttaca tctttgtgtc tacagatgaa gacagaaact
     4261 tcttccaagt aatccaagga tgaatgctga gaacatgaac tttgctgcaa gacgtctaga
     4321 agctgatcca cagtttatgt ttcaccccta tgtacattgg ggtggtgcta tcttgatttt
     4381 tacagaaact gtttttgaga attagcttgc cttgtgtata caaacctgaa ctagtttgac
     4441 ttcaaaactt cctgtatctt ttctgttctt actgactgca tacttgatga gatacttttt
     4501 gtttctttgg tttcttaaaa tatctgctat aggaacccac tggcaaaaat aggcagttat
     4561 cagtaaatta ttgaaacaca gaacaaggaa gtggaaaact gaactataaa tgaagtctgg
     4621 tactgattga tgttttgttt taagaaaaaa ctattttgta ctacagtttc tattgggaac
     4681 cactgccata tctaactcct ttttaagaat tctgtttgct tggcagcatc aatcagaagt
     4741 ttaactttgt aacagatttc tcacatctaa acagacatta gaagcttggc cagtttgtac
     4801 agctatgtaa cacaactgca atcaggtgct taccttacct cctgtgttaa ctttatacag
     4861 tcatttccac tgcaccactt cttcagacca aggagcaaga aagatcattc ttgcataaag
     4921 aaatgaacta taattaaata tcactttatt ttgaaatgca
//
LOCUS       NM_001437758            4342 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 5, mRNA.
ACCESSION   NM_001437758 XM_063270501
VERSION     NM_001437758.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270501.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.29828.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  81641872-81642273   c
            403-583             JAXUCZ010000011.1  81639358-81639538   c
            584-654             JAXUCZ010000011.1  81637098-81637168   c
            655-825             JAXUCZ010000011.1  81634588-81634758   c
            826-978             JAXUCZ010000011.1  81633460-81633612   c
            979-1256            JAXUCZ010000011.1  81632731-81633008   c
            1257-1383           JAXUCZ010000011.1  81632129-81632255   c
            1384-1530           JAXUCZ010000011.1  81631579-81631725   c
            1531-1625           JAXUCZ010000011.1  81631398-81631492   c
            1626-1820           JAXUCZ010000011.1  81627329-81627523   c
            1821-1912           JAXUCZ010000011.1  81625109-81625200   c
            1913-1957           JAXUCZ010000011.1  81624400-81624444   c
            1958-3306           JAXUCZ010000011.1  81622398-81623746   c
            3307-3402           JAXUCZ010000011.1  81622212-81622307   c
            3403-3530           JAXUCZ010000011.1  81621930-81622057   c
            3531-4342           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4342
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             325..3537
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 5"
                     /protein_id="NP_001424687.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEW
                     DAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKM
                     VTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA
                     TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVT
                     LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT
                     FVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV
                     GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDP
                     PDLLSVELSTSRPTQHLGRMKREPPPRPPQPAIFTHKPTYDPVSEDPDPLSSDFKRLG
                     LRKPALPRGLWLAKPSARVPGTKAGRSSGGEVTLIDFGEEPVAPTPRPCAPSLAQLAM
                     DACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINS
                     TLVSAGLPTGPSQGETNYAFVPEQAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQAL
                     QQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEASR
                     WPGPSSPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPK
                     YATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEE
                     PAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRASAR
                     LPQRGCPGDGQEAARPADKVQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVEQL
                     FGLGLRPRVECHKVLEMFDWNLEQAGCHLLGSCGPAHHKR"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    757..1530
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    757..1530
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179,
                     1234..1248,1273..1275,1375..1377)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179,
                     1234..1248,1273..1275,1375..1377)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(763..771,787..789,835..837,841..843,982..993,
                     1003..1005,1123..1125,1135..1140,1144..1146,1177..1179)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1123..1125,1135..1137,1234..1248,1273..1275,
                     1375..1377)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1123..1125,1135..1137,1234..1248,1273..1275,
                     1375..1377)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1206,1210..1254)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1206,1210..1254)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1552..1701
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1552..1701
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1558..1560,1564..1566,1579..1581,1633..1635,
                     1639..1641,1684..1686,1690..1695)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(1558..1560,1564..1566,1579..1581,1633..1635,
                     1639..1641,1684..1686,1690..1695)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    1714..1911
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1714..1911
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <2152..3282
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2152..3282
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2758..2934
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2758..2934
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3295..3426
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3295..3426
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3385..3504
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3385..3504
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            403..583
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..654
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..825
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..978
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1256
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1383
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1530
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1625
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1820
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1912
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1957
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..3306
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3530
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..4342
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcaag caggcggtgg ggggaagctg gggagtagga ccagagctgt gagcactgca
       61 ctggagacag gacagaggac ccagcctgtg accagctgtg gaaacccagc caggcttgca
      121 ggggagccaa gccaccactc cattcttctt ccctgtttcc tacttctgtg tgggatctga
      181 gggatttcta ggacctgttc cccctactct ctgggcagac catagaactc agaagctggg
      241 gcccttgcct gcccacttta gaacgaggcc atagctcctg tgacttaggg gcttcagctt
      301 gtggaggggc ttcagcttgt ggagatgcca gcagcccgtc gatttcctgg ccttgagctc
      361 tccttccctc tcctggccag actgcggcga cgactgtata caaggctggg gagcagcagc
      421 atgcagccgg aggagggaac aggctggctg ctggagctgc tgtctgaggt gcagctacaa
      481 cagtatttcc tgaggctccg agatgacctc aacattaccc gcctgtctca ttttgagtat
      541 gtcaaaaacg aagacctgga aaagattggc atgggccggc ctggccagag gcggctatgg
      601 gaggctgtga agaggaggaa ggccatgtgc aaacgcaagt catggatgag caagagcacc
      661 ttccggaagc cctcccccac cccagggggc ctggcagggg aggggaccct gcagagcctc
      721 acctgcctca ttggggagaa agacctgcgc ctgctggaga agctgggaga tggctccttt
      781 ggcgtggtgc gcaggggtga atgggatgcc cctgcaggga agacggtgag tgtggccgtg
      841 aagtgcctga aacctgatgt gctgagccag cccgaggcca tggacgactt catccgggag
      901 gtcaatgcca tgcattcgct agaccaccga aacctcattc gcttgtacgg tgtggtgctc
      961 acaccaccca tgaagatggt gacagagctg gcccctctgg gatccttgtt ggaccggcta
     1021 cgtaaacacc aaggtcattt cctcttgggg acgctgagtc gctatgccgt gcaggtggct
     1081 gagggcatgg gctacctgga gtccaagcgc ttcattcacc gagacctggc tgctcgaaat
     1141 ctgcttttgg ccacccgtga cctggtcaag attggggact ttggactgat gcgagctctg
     1201 ccccagaatg atgaccacta tgtcatgcaa gaacatcgca aggtgccctt tgcctggtgt
     1261 gcccctgaga gcctgaagac acggactttc tcccatgcca gtgacacctg gatgtttggg
     1321 gtcacactgt gggagatgtt tacgtatggc caggagccct ggattggcct caatggcagc
     1381 cagatcctgc ataagattga caaggaaggg gagcgcctgc cccggcctga ggactgcccc
     1441 caagacatct acaatgtcat ggtccagtgc tgggcccaca agccagagga cagacccaca
     1501 tttgtggccc ttcgggactt cctgctggag gctcagccta cagacatgcg ggcccttcag
     1561 gacttcgagg agccggacaa gctgcacatc cagatgaacg acgtcattac tgtcattgag
     1621 ggaagggctg agaactactg gtggcgtggt cagaacacac ggacgctgtg tgtgggaccc
     1681 ttccctcgaa atgtggtgac ctctgtggct ggcctgtcag cccaggacat cagccagcct
     1741 ctacagaata gcttcattca cacagggcat ggcgacagtg acccccgcca ctgctggggg
     1801 ttccctgaca ggatcgatga actgtacctg ggaaacccca tggacccccc tgacctgctg
     1861 agtgtggaac tgagcacctc gcgacccacc cagcatttag gacggatgaa aagggagcct
     1921 ccacctcgcc cacctcagcc tgccatcttc actcacaagc caacatatga ccctgtgagt
     1981 gaggacccag accccctgtc cagcgacttc aagagacttg gcctgaggaa gccagccctg
     2041 ccccgagggc tctggctggc aaagccctca gcccgggtgc caggcaccaa ggcaggccgc
     2101 agcagtgggg gtgaggtcac actcatcgac ttcggcgagg agcctgtagc cccaacccca
     2161 cggccctgtg caccttcctt ggcacagttg gccatggatg cctgctccct gctggacaag
     2221 acaccaccac agagccccac acgggcactg ccacgacctt tacatcctac acctgtggtg
     2281 gactgggacg ctcgcccgct gcccccgccc cctgcctacg atgatgtggc ccaagatgag
     2341 gatgacttcg aggtgtgctc tatcaacagc accctagtga gtgcaggcct ccctaccggg
     2401 cctagccaag gcgagaccaa ttatgcgttt gtacctgagc aggcccagct gccccctgcc
     2461 ctggaggata acctgttcct gccaccgcag ggtggaggcc agccacccag ctcagcccag
     2521 actgcagaga ttttccaggc actgcagcag gagtgtatgc ggcagctaca ggtccccact
     2581 ggccagctga ccccgtcccc taccccagga ggtgatgaca agccccaggt gccaccccgg
     2641 gtacctattc cccctcggcc cacacgtcca cgtgtgggac tatctccagc tcccttaggt
     2701 gaggaagagg caagtcggtg gcctggaccc tcctcccctc cccgagtgcc tccccgggaa
     2761 cccctgtctc ctcaagggtc gaggacccca agccccctag taccacctgg cagctcccca
     2821 ctaccgcatc ggctctcgag ctcacctgga aagaccatgc ccaccaccca gagctttgcc
     2881 tcagacccta agtacgccac tccacaagtg atccaggctc ctggcccacg ggctggcccc
     2941 tgcatcctgc ccattgtccg tgatggcagg aaggtcagca gcacccacta ttacctgctg
     3001 ccagagcgcc ctccctacct cgagcgctac cagcgcttcc tgagggaggc ccagagcccc
     3061 gaggagccgg ccgccctgcc cgttccccca ctgctgcccc cgcctagcac tccagcccct
     3121 gccgccccca ctgccaccgt ccgacctatg cctcaggctg ccccagaccc aaaggccaac
     3181 ttctccacca ataacagcaa cccaggggcg cagccaccat ccctgagggc cagtgcacgg
     3241 ctgccgcaga ggggctgccc aggggatggg caagaggctg cccggccagc agacaaagtc
     3301 cagatgctgc aggccatggt gcatggggtg accacagagg agtgccaggc ggccctgagg
     3361 agccacagct ggagtattca gagggctgcc cagtatctga aggtggagca gctctttggg
     3421 ctgggtcttc ggccacgggt ggagtgccac aaagtgctag agatgttcga ctggaaccta
     3481 gagcaagccg gctgtcacct tctggggtcc tgtggccctg cccaccacaa acgctgatgg
     3541 ttgactggag agcaatggtc tgccctaaga gaacctcttg aacctgtctg tgggacaagg
     3601 gtggggagat gccctgcctc aggcctggag gacccacaac tgcctgcggc tcccagtgga
     3661 cagtgagacc caggcagcag gaggctggga gcctcacctt gcccacctcg ctcacccacc
     3721 cagcgctgtt ctgcacacct tggttcagcc ctcagtgccc caaccaagag gtgggaagtt
     3781 ccaagccttg tgaaggcaag acaggaagct gcctggcagg ccctgtgtgt gacctgcctt
     3841 tggccccaga ccaaggctgg gctggtggct agagtgtgcc ccaggctttc cctgggggat
     3901 tagactgaga ggaagccagg cttgacttgg acaagaagga tgtgttggcc acacagaagg
     3961 gtgggccagc acccaacagg ccctcctcag gaccaggccc ctttccaggg aacccctgta
     4021 ggaatgtgga gtgttggaca gaatgtgacc tgtggcttca ctgtgaactc gggcttggct
     4081 ggtcttagat cttgtagctg taaacagcct gaagtggctc agaaacagaa gaggcgccag
     4141 gatcttctct ggcagggacc agggccccag gccccgggtg tggagggaga ccccagcggc
     4201 accagtactt gtcctgtttg atgcctgttc ctcccctgtg tccatttgat gtgttcccat
     4261 cgcctctgtt gccaaagctg ctgtcccagc catggatatc tgcttcttcc agagaaataa
     4321 agtctgtttc tattttacgt ca
//
LOCUS       NM_001437708            3224 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 6, mRNA.
ACCESSION   NM_001437708 XM_063270253
VERSION     NM_001437708.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3224)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3224)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3224)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3224)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3224)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3224)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3224)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.46681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000011.1  48369318-48369425   c
            109-210             JAXUCZ010000011.1  48315298-48315399   c
            211-298             JAXUCZ010000011.1  48308534-48308621   c
            299-516             JAXUCZ010000011.1  48198562-48198779   c
            517-668             JAXUCZ010000011.1  48179141-48179292   c
            669-872             JAXUCZ010000011.1  48168955-48169158   c
            873-953             JAXUCZ010000011.1  48168156-48168236   c
            954-1025            JAXUCZ010000011.1  48166329-48166400   c
            1026-1082           JAXUCZ010000011.1  48158140-48158196   c
            1083-1130           JAXUCZ010000011.1  48157502-48157549   c
            1131-3224           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3224
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..108
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            109..210
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     exon            211..298
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1651
                     /gene="Erg"
                     /note="isoform 6 is encoded by transcript variant 6; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 6"
                     /protein_id="NP_001424637.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MIQTVPDPEAQIKEALSVVSEDQSLFECAYGTPHLAKTEMTASS
                     SSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVG
                     SPDTVGMSYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLL
                     DVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKA
                     LQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKTEDQRPQLDP
                     YQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARR
                     WGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSL
                     YKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRL
                     PASHMPSHLGTYY"
     misc_feature    623..874
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    623..874
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1139..1390
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1139..1390
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            299..516
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            517..668
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            669..872
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            873..953
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1025
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1082
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1130
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..3224
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctgccc ggcccggccc ggcatgtgcg tgggcacacg cgggcgcgga cacgcgcggg
       61 cacccacgag ctggacagac cctccccgac ggcagcaccg ggctctgggt tgttctaaga
      121 tctttggtga cctgagaaaa gctgtgttgg tcaagagcaa gacaaatgac tcccagagag
      181 aaaggatggc gaaaccaagg acaatcagag ctgtcccggg ttctacacag ctggtgaggg
      241 agctggcctg ctgaaggtca tgatccagac tgttcctgac ccagaagctc agattaagga
      301 ggccttgtca gttgtgagcg aggaccagtc actatttgag tgtgcctacg gaacgccaca
      361 cctggctaag acagaaatga ccgcatcctc ttccagtgac tatggccaga catccaagat
      421 gagtcccaga gtcccacaac aggactggct gtctcagccc ccagccaggg tcaccatcaa
      481 gatggagtgc aaccctagcc aggtgaacgg ttccaggaac tcacctgacg aatgcagtgt
      541 gaccaaaggt gggaagatgg tgggcagccc tgatactgtg ggaatgagct acggcagcta
      601 catggaggag aagcacatgc cgccccccaa tatgaccacg aatgaacgca gagtgatcgt
      661 ccctgcagat cctactctgt ggagcacaga ccatgtccgg cagtggctgg agtgggcagt
      721 gaaagaatac ggcctcctag acgtggacgt cttattattt cagaatattg acgggaagga
      781 gctgtgcaag atgacaaaag atgacttcca gaggctcact ccgagctaca atgccgacat
      841 tcttctctca catctccact acctcagaga gactcccctt ccacatctga catccgacga
      901 cgttgataag gctttacaaa actctccacg gttaatgcat gctagaaaca cagggggtgc
      961 agcttttatt ttccccaata cttcagtata tcccgaagcc acgcagagaa ttacaactag
     1021 gccagctgcc cagccatctc cctccacagt gcccaaaact gaagaccagc gtcctcagtt
     1081 agatccttac cagatcctgg gacccaccag tagtcgcctt gctaatccag gtagtggcca
     1141 gatccagctg tggcagttcc tgctagaact cctgtctgac agctccaact ccaactgcat
     1201 cacctgggaa ggcaccaacg gggagttcaa gatgacagac ccggatgagg tggctcggcg
     1261 ctggggggag cggaagagca agcccaacat gaactatgac aaactcagcc gtgccctccg
     1321 ctactactac gacaaaaaca tcatgaccaa ggtgcatggg aagcgctatg cctacaagtt
     1381 tgacttccac gggattgccc aggccctgca gccccatccc cccgagtcgt ccctgtacaa
     1441 gtacccctcc gacctgccgt acatgggctc ctatcacacc cacccccaga agatgaactt
     1501 tgtggctccc caccctccgg ccctcccagt cacatcttcc agtttctttg ctaccccgaa
     1561 cccatactgg aattcgccga ctgggggcat ctacccgaac actaggctcc cagccagcca
     1621 tatgccctct cacctgggca cctactacta gagaccagat agaggccttt cccaacagtg
     1681 cacaatcgcc tagcaatcac cacaaactca gagaacacaa atcgaaagtg cctcctgagg
     1741 aatggaaacg gttggccaga gctggggaag gaagccgggg aaagaaaacc aaagactcac
     1801 aggggagggt gggcaccacc caagtattac tacagaaata gaagaagctc aaaatatact
     1861 gtacatggac atataacctg tggtccaccc ttgtcaaaga cattgtatgt agaaaagcgt
     1921 gaccgagaag aacaactgtc caaggaagtg gccttaagta gtgtacaaac tgtagagtgt
     1981 gggaccttgc ttgtaccagg attcagtgag agcaatagaa ccataacagt cttggcctag
     2041 cacaccatca cgtgtgatga catttgaagg gaaactacct gtgtttaaaa acagaaaaaa
     2101 acatatccaa accaaataag aagaggaaaa aaaaaaaaag atggcggccc ctccacagac
     2161 cacaatggct gtggattttc ttggctggca tttgctgttt tcattgaaat caggttcgtt
     2221 ccatttgata gggagctgcc agctctgtca aactgtgaag atgacccagc gtctcatcac
     2281 cttttcagta ttacgggaaa tgtgggccat gtggtgggcg gggaatgtat gtgcatgttg
     2341 ttgtgagtat gtgatcatag aagaaagact gaaacggagg aagagataga ggatcagggg
     2401 ttggggaggg agttaaggga gaggaggaag tggaagagga agaggaggag ggaggaggag
     2461 aaagggggag gaagaaaagg aggaagagga gaaaggagga ggaagaaaag gagaaaatga
     2521 ggaagagaag gaaaagaaga aaagaagggg gaggaagagg agaaggagga agaggaagag
     2581 aggaagagaa gcaagctgct caagccacca cagctgaatt taggacatct tgggaccaaa
     2641 gagcatgagt caagatgttt gatgctgcca gggttgtaag aaaggacaca gatttgtgga
     2701 ggactgggag cagtagtatt cagaaccaaa aatatgtctc tttgtgaaaa ggaaatcata
     2761 actggaattg tctgatattt aaaaaattca ggacctcagt attcaatgga ggctttgtcc
     2821 ttcacagggg gcagttgaga ggtgaccttg gtggctacca tggtcagaga ccacacaggc
     2881 attgtgggta ggtgggctcc agttttcctt aatgagtcgc gaacgctgtg cgttcgtcag
     2941 aacgaagtct acaagtcaat ggtttttttc tttttatata ataattatat aacttatgca
     3001 tttatacact acgagttgac ctcggccagc caaagacacc acacacacac acacacacac
     3061 acacacacac acacacacac acacaaaaga gacaatcaaa catatgatgt ggccttgaat
     3121 tttaactctg taatgcttaa tgtttacaat atgaagttac tagttcttag aatgcagaat
     3181 gtatgttaat aaaaatgagc ttggcctctc atggcgaacc agaa
//
LOCUS       NM_001437767            1672 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 5, mRNA.
ACCESSION   NM_001437767 XM_063270525
VERSION     NM_001437767.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 1672)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 1672)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 1672)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 1672)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.41306.1,
                                           SRR26360176.1665178.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000011.1  77465394-77465485   c
            93-162              JAXUCZ010000011.1  77464858-77464927   c
            163-279             JAXUCZ010000011.1  77462369-77462485   c
            280-442             JAXUCZ010000011.1  77461993-77462155   c
            443-572             JAXUCZ010000011.1  77456828-77456957   c
            573-666             JAXUCZ010000011.1  77452674-77452767   c
            667-766             JAXUCZ010000011.1  77449073-77449172   c
            767-945             JAXUCZ010000011.1  77444544-77444722   c
            946-1055            JAXUCZ010000011.1  77442290-77442399   c
            1056-1165           JAXUCZ010000011.1  77440692-77440801   c
            1166-1308           JAXUCZ010000011.1  77435682-77435824   c
            1309-1457           JAXUCZ010000011.1  77433449-77433597   c
            1458-1672           JAXUCZ010000011.1  77432471-77432685   c
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1672
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..92
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            93..162
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            163..279
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     CDS             180..1508
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 2 is encoded by transcript variant 5; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 2"
                     /protein_id="NP_001424696.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAASIKISSLGLERWLSG"
     misc_feature    1047..>1127
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1047..>1127
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    <1056..>1490
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1056..>1490
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1332..>1454
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <1332..>1454
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    1353..1409
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1353..1409
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            280..442
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            443..572
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            573..666
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            667..766
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..945
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1055
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1165
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1308
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1457
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1672
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag gtacgctgtg cgggtcgggc
       61 cctgaggtgg acgaacgcgg ggaaaagatg agtgattcct ggaagcagtg aagggcacgg
      121 ccttgggatt cttgattcct caaaggtcag cctagcaaca ggcataggtg gtagaaaaaa
      181 tgaagccagc gggtacagac ccaaggatct tgtctttagc tgctgaagta gcgaaaagtc
      241 ctgaacaaaa tgtccctgtt atattattga agttaaaaga aataataaac aacacccctt
      301 tgggaagctc agagttaaag aaagtcaagc aagatatata ttgttatgac ctcattcaat
      361 actgtctatt ggtcctcagt caagattctt ctcgaatcca gggtggttgg tctacaattt
      421 cccagctgac acagatacta agccattgct gtgtgggatt agagccagga gaagatggag
      481 aagaatttta caaggaatta cttccatcag ctgccgaaaa ttttcttgtc ctgggaagac
      541 gattgcaaac atgttttatc aatgcaacta agggtgaaga gcaagataaa ttactacatt
      601 ttttccaaat tgtgactgat tctctcttct ggctattggg aggtcatatt caactcatac
      661 agaatgtact gcagagtgat catttcttgc acctactgca aactgacaat gttcaaatag
      721 gagctacagt catgactctg cttcagaata tactacagat caacagtggt aatttactca
      781 aaatagaagg aaaagccctg cattctattt tagatgaaat tcttttcaag cttttgtcaa
      841 ctcctagtcc agtcataaga agtactgcta caaagctcct actggtattg gctgaatccc
      901 atcaggaaat tttgatttta ctgagactaa gtgcctgcta taaaggactt agaagtctgc
      961 taaataaaca ggaaactctt acagaattta gtcgagaact tagacagctc gttgatcttt
     1021 taacccctaa gatccaacag gaagtagaag aacagaaact acataaagca gcttgcttga
     1081 ttcaagccta ttggaaaggt ttccagacca gaaaaagatt aaagaagctt ccgtctgctg
     1141 tgattgcctt gcagaggagt ttcagagcta aacgaacaaa gatgttgttg gagctaaata
     1201 ggcagaagga agaagaagac ctcagattaa gattgcaact tcaaaaacag agagccatga
     1261 ggctttcccg agagtcacgc ttgagtatgc ttgaaataat tcatccaggt caagtggaga
     1321 aatacaatag ggaaatagaa gagaaatctg cattgactat ccagaaacat tggagagggt
     1381 acagggaaag gaagaatttt cgccaacaga ggccatctct cacagagtat aaagcagctg
     1441 tcacacttca gagagcagcc tctattaaga tttcaagtct ggggctggag agatggctca
     1501 gcggttaaga gcactgactg ctcttccaga ggtcctgagt tcaattccca gcaaccacgt
     1561 ggtggctcac aaccatctgt aatgggatct gatgccctct tctgctgtgt ctgaagacag
     1621 ctacaatgta ctcttataca tgaaataaat aaagtaaatc tttaaaaaaa aa
//
LOCUS       NM_001008762            3892 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 9 member C1 (Slc9c1),
            transcript variant 1, mRNA.
ACCESSION   NM_001008762 XM_221463
VERSION     NM_001008762.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3892)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   2  (bases 1 to 3892)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_001008762.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000011.1  68740757-68740859   c
            104-357             JAXUCZ010000011.1  68738514-68738767   c
            358-458             JAXUCZ010000011.1  68737292-68737392   c
            459-587             JAXUCZ010000011.1  68735441-68735569   c
            588-753             JAXUCZ010000011.1  68734127-68734292   c
            754-879             JAXUCZ010000011.1  68731230-68731355   c
            880-1041            JAXUCZ010000011.1  68729739-68729900   c
            1042-1141           JAXUCZ010000011.1  68727024-68727123   c
            1142-1285           JAXUCZ010000011.1  68725462-68725605   c
            1286-1460           JAXUCZ010000011.1  68724252-68724426   c
            1461-1542           JAXUCZ010000011.1  68722851-68722932   c
            1543-1709           JAXUCZ010000011.1  68721131-68721297   c
            1710-1835           JAXUCZ010000011.1  68719387-68719512   c
            1836-1933           JAXUCZ010000011.1  68710052-68710149   c
            1934-2053           JAXUCZ010000011.1  68707948-68708067   c
            2054-2249           JAXUCZ010000011.1  68705164-68705359   c
            2250-2435           JAXUCZ010000011.1  68702161-68702346   c
            2436-2585           JAXUCZ010000011.1  68700108-68700257   c
            2586-2637           JAXUCZ010000011.1  68698708-68698759   c
            2638-2786           JAXUCZ010000011.1  68697254-68697402   c
            2787-2912           JAXUCZ010000011.1  68693952-68694077   c
            2913-3011           JAXUCZ010000011.1  68692683-68692781   c
            3012-3194           JAXUCZ010000011.1  68689006-68689188   c
            3195-3326           JAXUCZ010000011.1  68682499-68682630   c
            3327-3512           JAXUCZ010000011.1  68682196-68682381   c
            3513-3639           JAXUCZ010000011.1  68680194-68680320   c
            3640-3692           JAXUCZ010000011.1  68676184-68676236   c
            3693-3892           JAXUCZ010000011.1  68674380-68674579   c
FEATURES             Location/Qualifiers
     source          1..3892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3892
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
     exon            1..103
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            104..357
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    195..197
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="upstream in-frame stop codon"
     CDS             210..3755
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; solute carrier family 9, member 10; solute
                     carrier family 9, subfamily C (Na+-transporting carboxylic
                     acid decarboxylase), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 10 isoform 1"
                     /protein_id="NP_001008762.2"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
                     /translation="MEEVFENLTTTHNVKLSNAWLDLLKSVFLSTPQDLPEIILILSL
                     ICTIGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFFGI
                     FTPVIIFNVAFDMDIYMLQKLFWQILLITIPGFMINYTLILWYLQSVNKLSLKTIPWL
                     LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKH
                     MNHTLAHKVMSTAWSYLVESFITGILITKAIQLWMATIFGDDVNHITLIFSVLYLIFY
                     VCELIGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPA
                     HTYLYISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKG
                     TPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIVNRFILPMAVIKLGLRDVT
                     STKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTE
                     HQKVKCPDCNKEIDETLNIEAMELANRRLLSAQIASYQRQYRNEILSQSAMQVLVGAA
                     GSFGEKKGEYMSPENIKNYSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHS
                     IVFTNEFEYTGYIAVLMNTYPMIICWISRLKDIYQYEIKCANYYFLTFYILEALLKVA
                     AMRKEFFSHTWLLFELGITLVGILDIILIETDSISYKFDLTETVVFMNVVRLLRILRI
                     LKLITPKLLQVIDKRMSQQISFRYAILKGYVQGEMDVLNIIDQIASSKQAKQILLKRV
                     IRNMDHAMKELGYLEYDHPEIAVTMKTKEEVNVMLNMAREIVKAFRSKGIIHKVEGAE
                     INKLIMAKKKQVLELQSVIQPLNVEEAPYYIPWLSEDPEAISFIQEKAKVVTFDCGNN
                     IFEEGDEPEGIYVIISGMVKLKRSKPHLEMDRVSSESEVAQTRSYTLPHTEYLLSGEI
                     IGELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKKYPNMKYKMWQKIGLAITAQ
                     KIRENLSFEDWNYKMQLKLCNVFVRDIPKTTKTDIYDETVTHVVLIHGSAEDCQLRKI
                     YKAPFLIPVTCHQIQGLEEFTKVMIIQTSVAVRKFRWNVKKYNPPRRISMKPDSTESL
                     ETLNESSEDDEDKKENEENEEYLEDIIDISSVSKK"
     misc_feature    318..1877
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    318..1877
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    2886..3269
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    2886..3269
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(3129..3134,3159..3167)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3129..3134,3159..3167)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3225..3233,3246..3254)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3225..3233,3246..3254)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            358..458
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            459..587
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            588..753
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            754..879
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1041
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1141
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1285
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1460
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1542
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1709
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1835
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1933
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2053
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2249
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2435
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2585
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2637
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2786
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2912
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3011
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3194
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3326
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3512
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3639
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3692
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3892
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtcagt gaggttgcag ttggttttgg acagttctgg agtgagagga agttcctggc
       61 ctccacttct cacattctct aggacactcc tgtgccctgg atgaagggca ttaggaagac
      121 accaagaaga aaagtcctat tccctttgat cccctgtgag tttttcagag acacagagtt
      181 tgagacgctg actgtaatta aatacgggaa tggaagaagt ttttgagaat ctaactacaa
      241 cccacaatgt caaactgagt aatgcatggc tggatcttct caaaagcgtg tttttgagca
      301 ctccccagga cctccctgaa atcatcttga tactatcttt gatctgtacg attggagcat
      361 ttttgaacat gcatctgaag gattttccaa ttcctcttcc tgtgatacta tttttaattg
      421 gatgctgttt tgaaattctg agttttgcat ctactcagat ccagttatat gcagatgcca
      481 tacagtggat ggatcctgac atgttttttg ggatatttac accagtaatt atctttaatg
      541 ttgcatttga catggatata tacatgcttc aaaagttatt ttggcagata ttattaatta
      601 caattcctgg atttatgatt aattacacct taatactgtg gtatctgcag tctgtgaata
      661 aattatcttt aaagaccatc ccctggctac tgttttcagc tgtgcttatc agttcagatc
      721 ctatgcttac ttcagcctcc ataagagacc ttggtctttc cagaagcctc acaaatttaa
      781 ttaacggaga gagtctactg acctcagtga tatccttaat tatatatagt gctgttgtgc
      841 agatcagttt caagtcaaag catatgaacc ataccctagc ccataaggtc atgtccacag
      901 cttggtcata tcttgtggaa agtttcatca ctggaatcct aattacaaaa gcgattcagt
      961 tatggatggc taccatcttt ggtgatgacg tcaaccacat cacgctcatc ttctcagttc
     1021 tatacctcat cttctatgtt tgtgagctaa ttggaatgtc tggaatattt actctggcca
     1081 ccataggact ttttctaaat tctacaagtt ttaaaccagg agttgaagca tttctcctcg
     1141 aattctggaa ctgcctgtcc tttattggtt tccttatggt gttcactttc attggacttc
     1201 taatccctgc acacacatat ttatatatat cattttctga tgtgtattac tcattaaata
     1261 tctacttcac gctgattgtt ttaaggcttc tggtctttct gctaatgagc cccattttgt
     1321 ctcgacttgg tcacgggttc agctggcgct gggcgttcat catggtctgg agtgaaatga
     1381 aaggaacacc gaacataaat atggcccttc tgcttgccta ctcggacgtt tctcttggtt
     1441 ccgagaggga aagatctcaa atattattcc atggcgtgtc agtatgtgta atcaccctga
     1501 ttgtcaatag atttattttg ccaatggcag taattaaact aggtcttcgt gatgtcacat
     1561 caacaaaata taaatcggtt tattatacat tccagcactt tcaagagcta accaaatcca
     1621 cagccatggc actcaaattt gacaaagatc ttgctaacgc tgactggaac atggttgaca
     1681 aggcgattat acttcaaaat ccatatgctt taaaccaaga agaaacaacg gaacatcaga
     1741 aggtgaaatg tcctgattgc aacaaggaaa tagatgagac ccttaacatt gaagccatgg
     1801 agttggccaa caggcgtctc ctgtcagcgc aaatagcaag ctaccaacga cagtacagga
     1861 atgagattct gtcccagagt gcaatgcaag tgttggtagg cgcggccgga agctttggtg
     1921 agaagaaggg agaatatatg agtcctgaga acataaagaa ttattcagaa agcaaaaaac
     1981 tcctctcctt tcttagaaaa ttactactca actgggtata taatactaaa aaagataaag
     2041 gggttccatc aagatacatg tttcttcatg catgccatag catagtcttc acaaatgaat
     2101 ttgaatacac tggatacatc gctgtattaa tgaacacata tccgatgata atctgttgga
     2161 tttcccgact aaaagacatc tatcaatatg agataaaatg tgctaactac tattttctta
     2221 cattttatat tctagaggct ctacttaagg tggcagcaat gaggaaggaa tttttttcac
     2281 acacctggct cctgtttgag ctcgggatta ccttggtcgg catcctagat ataatactta
     2341 tcgaaacaga ctccattagt tacaaatttg acttaactga gactgtggtc ttcatgaacg
     2401 tggttcgact ccttcgtata ctgcgcatct tgaagcttat aacaccaaaa ttgctgcaag
     2461 taatagacaa aaggatgagc cagcagatat ccttccggta tgctatacta aaaggctacg
     2521 tccaagggga aatggatgta ctgaatataa ttgatcagat tgcaagttcc aaacaggcta
     2581 aacagatatt gttaaagcga gtaataagga atatggatca tgctatgaaa gagctgggct
     2641 acctagagta tgatcaccca gaaatcgctg tcactatgaa aaccaaggag gaggttaatg
     2701 tgatgctcaa tatggccaga gaaattgtca aggctttcag gtccaaagga attatacata
     2761 aggtggaagg cgctgagatc aacaagttaa tcatggccaa aaagaaacaa gtgcttgagc
     2821 tgcagtctgt tatccagcca cttaatgttg aagaagcccc atactatatc ccatggctca
     2881 gtgaagatcc tgaagccata agctttattc aggaaaaagc aaaagttgtg acatttgact
     2941 gcggaaataa catatttgag gaaggcgacg aaccagaagg aatctatgta ataatttcgg
     3001 gcatggtaaa gcttaaaagg tcaaagccac acctggagat ggatagagtg tcctcagagt
     3061 cagaggttgc tcagactaga agttatacac tgcctcacac agaatatctg ctcagcgggg
     3121 aaataatagg agagttaaac tgtttgacta aagaacggat gcaatattct gccacctgca
     3181 aaactgttgt ggagacgtat tttattccca ttagccactt gtatgaaggc tttgaaaaaa
     3241 aataccctaa catgaaatat aaaatgtggc aaaaaatcgg acttgccatt actgcccaaa
     3301 agatccggga aaacttatct tttgaggact ggaactacaa gatgcagttg aaactctgca
     3361 atgtcttcgt aagggacata cccaagacca caaaaactga catctatgat gaaacggtaa
     3421 cccatgttgt cctcatccat ggatctgcag aagactgcca gttgcgaaaa atttataagg
     3481 cacctttcct aattcccgtg acatgccatc agatacaagg cttagaagag ttcacaaaag
     3541 tcatgattat tcaaacttcc gttgctgtga gaaaattcag gtggaatgta aaaaagtaca
     3601 acccacctcg aaggatttca atgaaaccag attctacaga atcacttgaa acattaaatg
     3661 aaagttctga agatgatgag gataaaaaag agaatgaaga aaatgaggaa tatttggaag
     3721 atattattga catctcaagt gtctccaaga aataacctgg aaagaaagtt tagtcagtcg
     3781 cctgagcttc tcaccatggc aatgaaaaca tatatttatg gagatagaga caagccaaag
     3841 tttatatgcc tcttgtgtga taatgtgaat taaagtacct tgcactagtc aa
//
LOCUS       NM_133397               3095 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 1, mRNA.
ACCESSION   NM_133397
VERSION     NM_133397.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_133397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217228.1, BC072519.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000011.1  48251487-48251658   c
            173-390             JAXUCZ010000011.1  48198562-48198779   c
            391-542             JAXUCZ010000011.1  48179141-48179292   c
            543-746             JAXUCZ010000011.1  48168955-48169158   c
            747-827             JAXUCZ010000011.1  48168156-48168236   c
            828-896             JAXUCZ010000011.1  48158807-48158875   c
            897-953             JAXUCZ010000011.1  48158140-48158196   c
            954-1001            JAXUCZ010000011.1  48157502-48157549   c
            1002-3095           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3095
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..172
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     CDS             155..1522
                     /gene="Erg"
                     /note="isoform 1 is encoded by transcript variant 1; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 1"
                     /protein_id="NP_596888.2"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGM
                     SYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTDLPYEPPRRSTWTGHSHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS
                     SRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKP
                     NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLP
                     YMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPSH
                     LGTYY"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1010..1261
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1010..1261
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            173..390
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            391..542
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            543..746
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            828..896
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            897..953
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1001
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..3095
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatagaaacc tcttcctgcc attggctgac ttcatttccc agacttagca caatctcatc
       61 cgctctaaac aacctcatca aaactacttt ctggtcagag agaagcaata attattatta
      121 acatttatta acgatcaata aacttgattg cattatggcc agcactatta aggaggcctt
      181 gtcagttgtg agcgaggacc agtcactatt tgagtgtgcc tacggaacgc cacacctggc
      241 taagacagaa atgaccgcat cctcttccag tgactatggc cagacatcca agatgagtcc
      301 cagagtccca caacaggact ggctgtctca gcccccagcc agggtcacca tcaagatgga
      361 gtgcaaccct agccaggtga acggttccag gaactcacct gacgaatgca gtgtgaccaa
      421 aggtgggaag atggtgggca gccctgatac tgtgggaatg agctacggca gctacatgga
      481 ggagaagcac atgccgcccc ccaatatgac cacgaatgaa cgcagagtga tcgtccctgc
      541 agatcctact ctgtggagca cagaccatgt ccggcagtgg ctggagtggg cagtgaaaga
      601 atacggcctc ctagacgtgg acgtcttatt atttcagaat attgacggga aggagctgtg
      661 caagatgaca aaagatgact tccagaggct cactccgagc tacaatgccg acattcttct
      721 ctcacatctc cactacctca gagagactcc ccttccacat ctgacatccg acgacgttga
      781 taaggcttta caaaactctc cacggttaat gcatgctaga aacacagatt taccttatga
      841 gcctcccagg agatcaacct ggaccggcca cagccacccc acccctcagt ccaaagctgc
      901 ccagccatct ccctccacag tgcccaaaac tgaagaccag cgtcctcagt tagatcctta
      961 ccagatcctg ggacccacca gtagtcgcct tgctaatcca ggtagtggcc agatccagct
     1021 gtggcagttc ctgctagaac tcctgtctga cagctccaac tccaactgca tcacctggga
     1081 aggcaccaac ggggagttca agatgacaga cccggatgag gtggctcggc gctgggggga
     1141 gcggaagagc aagcccaaca tgaactatga caaactcagc cgtgccctcc gctactacta
     1201 cgacaaaaac atcatgacca aggtgcatgg gaagcgctat gcctacaagt ttgacttcca
     1261 cgggattgcc caggccctgc agccccatcc ccccgagtcg tccctgtaca agtacccctc
     1321 cgacctgccg tacatgggct cctatcacac ccacccccag aagatgaact ttgtggctcc
     1381 ccaccctccg gccctcccag tcacatcttc cagtttcttt gctaccccga acccatactg
     1441 gaattcgccg actgggggca tctacccgaa cactaggctc ccagccagcc atatgccctc
     1501 tcacctgggc acctactact agagaccaga tagaggcctt tcccaacagt gcacaatcgc
     1561 ctagcaatca ccacaaactc agagaacaca aatcgaaagt gcctcctgag gaatggaaac
     1621 ggttggccag agctggggaa ggaagccggg gaaagaaaac caaagactca caggggaggg
     1681 tgggcaccac ccaagtatta ctacagaaat agaagaagct caaaatatac tgtacatgga
     1741 catataacct gtggtccacc cttgtcaaag acattgtatg tagaaaagcg tgaccgagaa
     1801 gaacaactgt ccaaggaagt ggccttaagt agtgtacaaa ctgtagagtg tgggaccttg
     1861 cttgtaccag gattcagtga gagcaataga accataacag tcttggccta gcacaccatc
     1921 acgtgtgatg acatttgaag ggaaactacc tgtgtttaaa aacagaaaaa aacatatcca
     1981 aaccaaataa gaagaggaaa aaaaaaaaaa gatggcggcc cctccacaga ccacaatggc
     2041 tgtggatttt cttggctggc atttgctgtt ttcattgaaa tcaggttcgt tccatttgat
     2101 agggagctgc cagctctgtc aaactgtgaa gatgacccag cgtctcatca ccttttcagt
     2161 attacgggaa atgtgggcca tgtggtgggc ggggaatgta tgtgcatgtt gttgtgagta
     2221 tgtgatcata gaagaaagac tgaaacggag gaagagatag aggatcaggg gttggggagg
     2281 gagttaaggg agaggaggaa gtggaagagg aagaggagga gggaggagga gaaaggggga
     2341 ggaagaaaag gaggaagagg agaaaggagg aggaagaaaa ggagaaaatg aggaagagaa
     2401 ggaaaagaag aaaagaaggg ggaggaagag gagaaggagg aagaggaaga gaggaagaga
     2461 agcaagctgc tcaagccacc acagctgaat ttaggacatc ttgggaccaa agagcatgag
     2521 tcaagatgtt tgatgctgcc agggttgtaa gaaaggacac agatttgtgg aggactggga
     2581 gcagtagtat tcagaaccaa aaatatgtct ctttgtgaaa aggaaatcat aactggaatt
     2641 gtctgatatt taaaaaattc aggacctcag tattcaatgg aggctttgtc cttcacaggg
     2701 ggcagttgag aggtgacctt ggtggctacc atggtcagag accacacagg cattgtgggt
     2761 aggtgggctc cagttttcct taatgagtcg cgaacgctgt gcgttcgtca gaacgaagtc
     2821 tacaagtcaa tggttttttt ctttttatat aataattata taacttatgc atttatacac
     2881 tacgagttga cctcggccag ccaaagacac cacacacaca cacacacaca cacacacaca
     2941 cacacacaca cacacaaaag agacaatcaa acatatgatg tggccttgaa ttttaactct
     3001 gtaatgctta atgtttacaa tatgaagtta ctagttctta gaatgcagaa tgtatgttaa
     3061 taaaaatgag cttggcctct catggcgaac cagaa
//
LOCUS       NM_001437790            3862 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus paired box 2 (Pax2), transcript variant 3, mRNA.
ACCESSION   NM_001437790 XM_063287134
VERSION     NM_001437790.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Wang,X.L., Hou,L., Zhao,C.G., Tang,Y., Zhang,B., Zhao,J.Y. and
            Wu,Y.B.
  TITLE     Screening of genes involved in epithelial-mesenchymal transition
            and differential expression of complement-related genes induced by
            PAX2 in renal tubules
  JOURNAL   Nephrology (Carlton) 24 (2), 263-271 (2019)
   PUBMED   29280536
  REMARK    GeneRIF: Pax2 overexpression by kidney tubule cells alters the
            expression of complement system proteins to induce
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   Hou,L., Du,Y., Zhao,C. and Wu,Y.
  TITLE     PAX2 may induce ADAM10 expression in renal tubular epithelial cells
            and contribute to epithelial-to-mesenchymal transition
  JOURNAL   Int Urol Nephrol 50 (9), 1729-1741 (2018)
   PUBMED   30117015
  REMARK    GeneRIF: PAX2 directly increased expression of ADAM10, the presence
            of which contributed to EMT in renal tubular epithelia and hence
            plays an important role in renal fibrosis.
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Larsson,M.
  TITLE     Pax2 is persistently expressed by GABAergic neurons throughout the
            adult rat dorsal horn
  JOURNAL   Neurosci Lett 638, 96-101 (2017)
   PUBMED   27939388
  REMARK    GeneRIF: Persistent Pax2 expression may be required to maintain a
            GABAergic phenotype.
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Jiang,Y., Jiang,T., Ouyang,J., Zhou,Q., Liang,Y., Cui,Y., Chen,P.
            and Huang,B.
  TITLE     Cell atavistic transition: Paired box 2 re-expression occurs in
            mature tubular epithelial cells during acute kidney injury and is
            regulated by Angiotensin II
  JOURNAL   PLoS One 9 (4), e93563 (2014)
   PUBMED   24710423
  REMARK    GeneRIF: Those findings suggest that mature TECs can
            trans-differentiate into progenitor-like cells by 'atavistic
            transition', which may participate in the recovery of tissue
            structure and Pax2 may play a pivotal role in this process.
            Erratum:[PLoS One. 2015 May 06;10(5):e0127718. doi:
            10.1371/journal.pone.0127718. PMID: 25945929]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3862)
  AUTHORS   Ryan,G., Steele-Perkins,V., Morris,J.F., Rauscher,F.J. 3rd and
            Dressler,G.R.
  TITLE     Repression of Pax-2 by WT1 during normal kidney development
  JOURNAL   Development 121 (3), 867-875 (1995)
   PUBMED   7720589
REFERENCE   7  (bases 1 to 3862)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   8  (bases 1 to 3862)
  AUTHORS   Sharma,P.M., Bowman,M., Yu,B.F. and Sukumar,S.
  TITLE     A rodent model for Wilms tumors: embryonal kidney neoplasms induced
            by N-nitroso-N'-methylurea
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9931-9935 (1994)
   PUBMED   7937920
REFERENCE   9  (bases 1 to 3862)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   10 (bases 1 to 3862)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063287134.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.3973.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000001.1  253555232-253555588
            358-468             JAXUCZ010000001.1  253565886-253565996
            469-637             JAXUCZ010000001.1  253569471-253569639
            638-835             JAXUCZ010000001.1  253570262-253570459
            836-921             JAXUCZ010000001.1  253597330-253597415
            922-1041            JAXUCZ010000001.1  253599070-253599189
            1042-1217           JAXUCZ010000001.1  253624514-253624689
            1218-1344           JAXUCZ010000001.1  253626927-253627053
            1345-1446           JAXUCZ010000001.1  253641498-253641599
            1447-1533           JAXUCZ010000001.1  253643737-253643823
            1534-3862           JAXUCZ010000001.1  253644297-253646625
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3862
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
     exon            1..357
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    207..209
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="upstream in-frame stop codon"
     CDS             333..1610
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; paired box protein Pax-2; paired box gene 2;
                     paired box protein 2; paired box homeotic gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2 isoform 3 precursor"
                     /protein_id="NP_001424719.1"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
                     /translation="MEQCAGRAVLKLSLRGDTAAAAALLPLLCLPMDMHCKADPFSAM
                     HPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGR
                     YYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTV
                     PSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSI
                     NGILGIPRSNGEKRKREEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVF
                     ERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYP
                     VVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAW
                     RFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH"
     sig_peptide     333..446
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    471..845
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    471..845
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    order(486..491,504..506,510..518,522..524,537..539,
                     573..575,579..581,606..608,615..617,621..626,636..638,
                     663..683,687..698,753..761,816..818,822..827,834..836,
                     843..845)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    order(486..491,504..506,510..518,522..524,537..539,
                     573..575,579..581,606..608,615..617,621..626,636..638,
                     663..683,687..698,753..761,816..818,822..827,834..836,
                     843..845)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    1269..1604
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     misc_feature    1269..1604
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     exon            358..468
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..637
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..835
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..921
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1041
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1217
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1344
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1446
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1533
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..3862
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttcgggt gcctctgggt agcgagggtg tgggtgtcgg cttgccggta gggctggggg
       61 cctcggtgcg tgtgcgcgcc tgtgcgcggc ccggagagcc cgcggcgcct cggcccgtgg
      121 ctgtgctcgg cggcctggtg tgcgagccag tgcacgatcg gagcggagcg cacagcccgc
      181 cctggcggcc ggcagccgct gttatctgag ccgctccgtc gcgggtggct gctcccggat
      241 ctcccggctg tggcggccaa ggcgagaccg actgtggggc ggctgaggag ccgggaagcc
      301 aagacccagg cccgggcagc agcgagccga gcatggaaca gtgtgcaggt cgagcagtcc
      361 tgaagttgag tttgagaggc gacacggcgg cggcggccgc gctgctcccg ctcctctgcc
      421 tccccatgga tatgcactgc aaagcagacc ccttctccgc gatgcaccca gggcacgggg
      481 gtgtgaacca gctcgggggg gtgtttgtga acggccggcc cctacccgac gtggtgaggc
      541 agcgcatcgt ggagctggcc caccagggtg tgcggccctg tgacatctcc cggcagctgc
      601 gggtcagcca tggctgtgtc agcaaaatcc tgggcaggta ctacgagact ggcagcatca
      661 agcccggagt gattggtggc tccaagccca aggtggcaac gcccaaagtg gtggacaaga
      721 ttgctgaata caagcgacag aacccgacta tgttcgcctg ggagatccgg gacaggctgc
      781 tagctgaggg catctgcgac aatgatacag ttcccagcgt ctcatccatc aacaggatca
      841 tccggaccaa agttcagcag cctttccacc caacgccgga tggggcaggg acaggagtga
      901 ctgcccctgg ccacaccatc gttcccagca cggcctcccc tcctgtttcc agcgcctcta
      961 acgacccagt gggatcctac tccatcaacg ggatcctggg gattcctcgc tccaacggtg
     1021 agaagaggaa acgagaggaa gatgtgtccg agggctctgt ccctaatgga gactcccaga
     1081 gtggtgtgga cagtttgcgg aagcacctgc gagccgacac cttcacccag cagcagctgg
     1141 aagctttgga tcgagtcttt gagcgtcctt cctatcccga tgtcttccaa gcatcagagc
     1201 acatcaaatc agaacagggg aatgaatact ctctcccagc cctgacccct gggcttgatg
     1261 aagtcaagtc cagtctatct gcatctacca accctgagct gggcagcaat gtgtcaggca
     1321 cacagacgta ccccgtcgtg accggtcgtg atatggcgag caccactcta cctggttacc
     1381 cccctcatgt gccccccact ggccagggaa gctaccctac ctccaccctg gcaggaatgg
     1441 tgcctgggag cgagttctca ggcaacccat acagccatcc ccagtacacc gcctacaatg
     1501 aggcttggag attcagcaac cccgccttac taagttcccc ttattattat agtgccgccc
     1561 cccggggctc cgcccctgcc gctgctgccg ctgcctatga ccgccactag ttaccgcggg
     1621 gaccacatca agcttcaggc agacagcttc ggcctccaca tcgtccccgt ctgaccgccc
     1681 accccagagg gagggaggac cgaagcgacg cgctgcctct cggccaccgt ccctgtccca
     1741 cccccacctc gagacatccc acgcccccga agcccttcac gtcaccctat caaggccaga
     1801 caggacaggt ggagcccagg gtgggaccct caggccccag ccccgcccgt cgcccctccc
     1861 cgcctgcctg gaccgcggcg ccgcccggaa gccctccggc cgctggcccg ggcgccggac
     1921 acgtttctgt gacacacaat cagcgtagcc cacccgggga cagcccactt tggacgcccg
     1981 ggagccggga ggcttcgctg gaggagctga gcaagggaag ctaaggaaag gactttgtgc
     2041 tgaaggagga gcggctggcg agggggggaa atcctgcccc actccccgag cctgccaggc
     2101 tgaatccgcc ttatgtctgc gcccggcccc aggcagtggc actgggacga aagggtcgga
     2161 ctcgagggac agcttttggg gcgacagcgt tttccgaggc tgggaaccaa ggctagcaga
     2221 cgccaactga gctcatccac ctgaactgcc tcgttcccca gggcctggga tctcctgctg
     2281 cagtggctcg actctcggcc ccgcctcgcc cctacgtcag cgcctcttcc acctgctggc
     2341 ctctcacttt tccctcctgc gcttccttgg ctcatcccac gacaccttgt gtttggtcct
     2401 aagcacgcag tcacgtcggg gccaccgcgg gaaccgtgtc ctcaggctgc ggctgtgagc
     2461 attgatcttt cccatcagta atgtgctgcc cccacacccc cgaccggccc caaaccccca
     2521 acctgcgggc gcaaagaact tggagggaac tgacgaccga actgccccga ggtgaaaacc
     2581 cgggactgcc cgccccattc ccctcaacaa cccccctccc cggacccccc aagccttccc
     2641 ttgggcagat gctgaacaga gccggaaaaa aaaagtctac acttatttaa tatgacagtc
     2701 tttgcaaaaa cgaacaaaac agaaacccaa caggctgctt tgtagaaaga cggtgtgtgc
     2761 tgtgaaggcg aacctctctg tgtacatatc ccctccctct ctgccccgcc ccgccgggta
     2821 ccgtagagtc cctgtcctcc ccaccaccct gcctgtagat acacccttct gtccgtgctg
     2881 tgagagtcgc cgctcgctgg gggggagggg ggacacagct acatgcccac taaagcacag
     2941 cacgtcctgg gggagggggg cattttttta cgttacaaaa acaaattatg aaagaaatct
     3001 ctatgcaaaa tgacgaacat ggtcccgcgg acacctctcg cctgtttcgt tggctgtttc
     3061 tctgtaattc cgtgttttcg cgctcaccgc cccgcatctc tccctcttca tctccctttt
     3121 ctctgctgct ctcggccctt ctgtgtctct ttctctgctt cacttgtctc tgtctcggtc
     3181 ccttctgtcc caggcctcca aggctacatc aaaggtggca gagccaatct cggggcttgg
     3241 ccccttgtgg ccatgcccca cgtgccccac caggccgccc tgccccgccc caccctgtag
     3301 ttgctctctc ggtagcggcg atgctccctg catgtctcct caaccgtgga tcgtgacgac
     3361 tcgaaataac agaaacaaag taaataaaag tgaaaaaaaa acaagtaaat aaataaataa
     3421 ataaataaat aaataaataa ataaataaaa atccttgaac aaatctgaaa aggcttggag
     3481 tcctagccca gattgcgctt cccttcgagc ctttttcttt gaaaaggaaa gcgagaaaag
     3541 agaacagtct aagggaactg ccggcacccg accgggctcc agtggctgga gccggatggt
     3601 gagggcaatg aggtctcggc ttcgaggccc agcctgaccc cagtcttgtg tggagctggc
     3661 cgcgctccag gagtgcggaa tccaggataa ggcttagcct tccacaagtt cctggctcct
     3721 ctgccacttt caacgtgtcg gttcgttttg tttatttttt cctttttccc cccttccttt
     3781 ccttctctct cttctttttt tatgcacatg ataaataata ataataaata ataataataa
     3841 taaaattttg tatgtcactc cc
//
LOCUS       NM_001437694            4921 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 14,
            mRNA.
ACCESSION   NM_001437694 XM_063270235
VERSION     NM_001437694.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4921)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4921)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4921)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4921)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4921)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4921)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4921)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4921)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4921)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4921)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270235.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.42047.1,
                                           SRR26643296.30243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-449             JAXUCZ010000011.1  98105694-98105740
            450-521             JAXUCZ010000011.1  98106090-98106161
            522-608             JAXUCZ010000011.1  98108322-98108408
            609-771             JAXUCZ010000011.1  98109928-98110090
            772-892             JAXUCZ010000011.1  98113029-98113149
            893-1024            JAXUCZ010000011.1  98115531-98115662
            1025-1231           JAXUCZ010000011.1  98117537-98117743
            1232-1352           JAXUCZ010000011.1  98123938-98124058
            1353-1508           JAXUCZ010000011.1  98124251-98124406
            1509-1598           JAXUCZ010000011.1  98124558-98124647
            1599-1691           JAXUCZ010000011.1  98126328-98126420
            1692-1748           JAXUCZ010000011.1  98128415-98128471
            1749-1943           JAXUCZ010000011.1  98131039-98131233
            1944-2053           JAXUCZ010000011.1  98131384-98131493
            2054-2213           JAXUCZ010000011.1  98133415-98133574
            2214-4921           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4921
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 14 is encoded by transcript variant 14;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 14"
                     /protein_id="NP_001424623.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWRVEAEEWGKFLHT
                     KNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVP
                     VGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLA
                     VITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQ
                     KKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDD
                     KSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGG
                     LNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQ
                     HCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFA
                     DACGLMNNNIEEQRRNRLARELPSAVSRDKVASAGGGIGDGGRIGDGGQEPTTGNWRG
                     MLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIER
                     LIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMA
                     QRRKEAADMLKALQGASQIIAEIRETHLW"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1058
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,588..590,
                     798..800,804..809,885..899,906..908)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,600..602,639..641,714..716,720..722,
                     726..737,741..746,807..809,813..824,894..902)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    588..599
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(594..599,687..692)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    795..806
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    825..1682
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    885..893
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1977..2249
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1977..2249
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..449
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..521
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..608
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..892
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1024
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1231
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1352
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1508
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1598
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1691
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1748
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1943
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2053
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2213
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..4921
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gagagttgaa gcagaagaat
      421 ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa attcgacaag
      481 aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc cctgagccaa
      541 tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat ttaccaggaa
      601 tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc agagaactta
      661 ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct gcaaatacag
      721 atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat gggcgcagaa
      781 ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc atggatgtat
      841 tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac aggagccaac
      901 tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat gcttttcttc
      961 aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct aggactctga
     1021 ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca agaataaatg
     1081 tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg gatgataaaa
     1141 gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac actattgaag
     1201 gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt tgttatattt
     1261 tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc cttaacacta
     1321 ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta tttgtgcctg
     1381 aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag cccagcctcc
     1441 gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt agcaactaca
     1501 gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa gtagtgactt
     1561 gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta gtggcaattg
     1621 agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg ctaatgaaca
     1681 ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc gctgtatcgc
     1741 gagacaaggt tgcatctgca ggtggtggaa ttggagatgg tggtcgaatt ggagatggtg
     1801 gtcaggaacc gacaacaggc aactggagag gaatgctgaa aacttcaaaa gctgaagaat
     1861 tacttgctga agaaaaatca aaaccaattc caattatgcc agcaagtcca caaaaaggcc
     1921 atgctgtcaa tttgctagat gtgccagttc cagttgcacg aaaactgtct gcccgagaac
     1981 agcgagattg tgaggttatt gaaagactca tcaaatcata ttttctaatt gtcagaaaga
     2041 atattcaaga cagcgtccca aaggcagtaa tgcatttttt ggttaatcat gtgaaagata
     2101 ctcttcagag tgaattagta gggcagctgt ataagtcatc cttattagat gaccttctga
     2161 ctgaatccga ggacatggca cagcgaagaa aagaagcggc tgacatgctg aaggcattac
     2221 aaggagccag tcaaattatt gctgaaatcc gagagactca tctttggtga acagaactgt
     2281 ttggtcttct acactttgct gacttgaacc tactagctac tgcctacctg agtagaaatt
     2341 tatttatgga cttttgtgta tcgcagtgta tgaatttgct tgtgtgaaga ctggctataa
     2401 gctgaaaagt atattattca ttacaagaca aatcacatgt ttaattcaca tttttcaagt
     2461 ttcctatgat gtatatcaag tctgtccgtt tcagtcaaac ttacaagaac aattgatgtt
     2521 ctagttgtac aaagcagttt gcctgtgcat atgatgacct gcgtaacctt tttttagtct
     2581 taaagctgca gccgtagtcc tcaaagagga agctccagga catttcatga ctataatgca
     2641 tgcactattt atatagactg acctggcttc aaaaggtgga gcctggcgag ttcctcacat
     2701 aatcaatgta tccacctatc cttcattttt atagtcttaa aaaacaaaca aaattctgaa
     2761 acttctgcag ttttaggaaa aatataagat ctgaaagact cataaagatg taggaacaga
     2821 ctgtgtaatt aatggctcct gagtctatac tgccctaatg ttagaaagta aaatatgctt
     2881 tgattcaaaa taagcctgaa aatataaatt gacttcctgc attaaaaata actattagga
     2941 actttcttag taacaataac tggtcctgtt agtttctaaa tgactcagtg acaacctaaa
     3001 tttccctaat ttacaagtac atcgattgca gtccagatgc accttagggt ggggcgctga
     3061 ctctgggctc cgagactcag ttatgtgaga cctaaaagtc tactctgtat ccactggtaa
     3121 tgctacttta tagttccaca ccaacagaat acatttgtca aagaaaaata cctggacata
     3181 cacatacacc taaaagctta tggactacta aactgtattc aggggttgag gatttacaac
     3241 ctattttgtg aaaactgcct gtgcaattca atttctgacc tagctgggca gtggtggtgc
     3301 acacctttaa tcccagcttt tgggaggcag aggcaggtgg atctctgagt tcaaggccag
     3361 cctggtctac agagttgagt tccaagacaa ccagaactac acagagaaac cctgtcttga
     3421 acccccctcc ccccaaaaaa ttgaaaccta aatagaaatc tttgatgtat ctagttttct
     3481 ctgaccaaat gatacatttg tgttataaat actaaaattc ttttcaggtc aggcatctta
     3541 tgaaatacta ttagcaagga aaacaagaac atgttatctt tagtttagat gcccattgaa
     3601 ccatctcaaa aacaaaggca gtctgataac agtaccagct tgacagtgag tatacactgc
     3661 ctaaatgtgt tagcatactt aagaaaaata tcctgttatc taactattag gtatccatgg
     3721 tttatttttt aagagagatg accaccactg tagccttttg aatttgtaaa gagaaagaat
     3781 gcacctttat ccaacatttc aaatagattt taaaaggaag atgttagctt taaaaacgtg
     3841 ctatgataat gtacttgtta gcactacaca ctttgtacaa agaaaaacaa gcaagaaagg
     3901 tagggaaatg aaagcttcct ttgtgtactt ttacactaag ctgtgttctg aaacatggag
     3961 ataatttata agaccactgt atgttctatg taaataaaaa tgctggtgtg aaatggcatt
     4021 acggtttgcc agtaagtgaa ttcttcctga cttgccgtaa gagagaggtt taaataggtg
     4081 catctttgaa atatctgaat ctacttcata atggaacgat ttaaattgta ctgcaccaaa
     4141 agttttatgc cattttttta attagataat caccaccaag gccttgttac atctttgtgt
     4201 ctacagatga agacagaaac ttcttccaag taatccaagg atgaatgctg agaacatgaa
     4261 ctttgctgca agacgtctag aagctgatcc acagtttatg tttcacccct atgtacattg
     4321 gggtggtgct atcttgattt ttacagaaac tgtttttgag aattagcttg ccttgtgtat
     4381 acaaacctga actagtttga cttcaaaact tcctgtatct tttctgttct tactgactgc
     4441 atacttgatg agatactttt tgtttctttg gtttcttaaa atatctgcta taggaaccca
     4501 ctggcaaaaa taggcagtta tcagtaaatt attgaaacac agaacaagga agtggaaaac
     4561 tgaactataa atgaagtctg gtactgattg atgttttgtt ttaagaaaaa actattttgt
     4621 actacagttt ctattgggaa ccactgccat atctaactcc tttttaagaa ttctgtttgc
     4681 ttggcagcat caatcagaag tttaactttg taacagattt ctcacatcta aacagacatt
     4741 agaagcttgg ccagtttgta cagctatgta acacaactgc aatcaggtgc ttaccttacc
     4801 tcctgtgtta actttataca gtcatttcca ctgcaccact tcttcagacc aaggagcaag
     4861 aaagatcatt cttgcataaa gaaatgaact ataattaaat atcactttat tttgaaatgc
     4921 a
//
LOCUS       NM_001437719            2746 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 116 (Ccdc116),
            transcript variant 2, mRNA.
ACCESSION   NM_001437719 XM_039088066
VERSION     NM_001437719.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2746)
  AUTHORS   Wang,Y., Wu,W., Zhu,M., Wang,C., Shen,W., Cheng,Y., Geng,L., Li,Z.,
            Zhang,J., Dai,J., Ma,H., Chen,L., Hu,Z., Jin,G. and Shen,H.
  TITLE     Integrating expression-related SNPs into genome-wide gene- and
            pathway-based analyses identified novel lung cancer susceptibility
            genes
  JOURNAL   Int J Cancer 142 (8), 1602-1610 (2018)
   PUBMED   29193083
REFERENCE   2  (bases 1 to 2746)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039088066.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.70220.1,
                                           SRR26360181.2164307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000011.1  97346672-97347066
            396-533             JAXUCZ010000011.1  97350002-97350139
            534-1082            JAXUCZ010000011.1  97351042-97351590
            1083-1682           JAXUCZ010000011.1  97351695-97352294
            1683-2746           JAXUCZ010000011.1  97353770-97354833
FEATURES             Location/Qualifiers
     source          1..2746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2746
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="coiled-coil domain containing 116"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
     exon            1..395
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..533
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    423..425
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="upstream in-frame stop codon"
     CDS             462..2555
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 116; stromal
                     cell-derived factor 2-like 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 116
                     isoform 1"
                     /protein_id="NP_001424648.1"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
                     /translation="MARCRHHSGYLADDEAAHGTYVARLPKKHLLPEMRPTCKLGRVP
                     HLPSMNRYSERQGHQQNLRRPRAFGGFLDFLTEGQVLDSLQTVVEQATECVATMKTEA
                     GVPLVDVQDRVEVPNSRHRSRGRPSINTVHRHRARPTLCAGHPNNYPSCSSSMSDSHS
                     SVTAGWLGSRSQDSDLGARGVGSLPPMRDKLLLEKNLKRLLRLESKGKVLNQHCSQRD
                     SLLWDSLGSQSSSQPTREQPLSWFSGLLASTSVTPETSELGLGEQEMIFLKQELNKEI
                     KSLLNQPTSFNLPTYCPLREPHRTLDFLSEHHLFPALQRVVSQAVDKLSHACRHNGFP
                     LFPVTSELSPVFPGNSDLQPSSKASLPTDREARGETCYSPTSASSPKTSHRKSKDRRG
                     SPSNAVQMATRFRLKSPNKFLKKKALPSISSVSSLSYISNPWFEELTNFLVEQAVSLL
                     ICKYKFEESLNKQLGFISFPITEVLMDIFLGFKKVKGTHIRLSSDINWTCLLRKLEEA
                     EMARQALRHVSRSGTSPHSTSRIVTSHHSTGPSSRQPELTRDTDQDQSPESHLSLHPA
                     LPIRQVMGPRDSRIGQKQTANTNQSEARRSVISTAGMGSKTKEVVNIEEGKDTEEEEE
                     EEEEEDEEEEDEEEEDEEEDEEEDEEEEEEEERGSEEEETKDFSECEHAPSPPLHELE
                     NSVNETTIVSPGDSQ"
     misc_feature    513..1688
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    513..1688
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    1500..1661
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1638..1640
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V8B5.1); phosphorylation site"
     exon            534..1082
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1682
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2746
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggggactt gcccaacaac tcccggaagc ggctgagttg agcttctagc tcctcccgca
       61 cctgaagaga ggggcacaga caccttgagc ttcgcgaagc cgccacaaag ccaggagctc
      121 cgtctggtgc tacgatgcga ctgctccagc ctttgaacta gagagtatac ccagcgcccg
      181 cttttgaccc aacgacttcc atgataccct ctgggctgag atttgaagat caagatgagt
      241 atccccctgc ggccacgcct ccgcacctgg ggcaaagcaa cgtctccagc cgctaaggcc
      301 tctcgaaatc ccatcttgcc aagaaagaag ccttccggac tgaggagcga cgaggcgttg
      361 tggcgggccg ggcccaccgg acggccctca gacagaggag tctgcatctg tgctgtagga
      421 cctgaagaag gaagcagaaa acaaatttaa ttatccacat catggcaagg tgccgccacc
      481 actcaggtta tctggctgac gacgaggctg ctcacggcac ctatgtggct cggctgccca
      541 agaagcatct gttgccagag atgaggccaa cttgcaagct tgggcgtgta ccacacctac
      601 catcaatgaa ccgatactca gagcgccagg gccaccagca aaaccttagg cgccctcggg
      661 catttggtgg cttcctggat ttcctcacgg agggtcaggt actggacagc ttgcagacag
      721 tcgtggagca ggcaacagaa tgtgtggcta ccatgaagac agaggctgga gtgccactgg
      781 tggatgtaca agaccgagtg gaggtgccaa atagtaggca tcgttctcga ggcagaccca
      841 gcatcaacac tgtgcatcgg caccgtgctc ggcccacgct gtgtgctgga cacccaaaca
      901 attacccatc ttgctccagc tccatgtctg actcccatag cagcgtcaca gctggatggc
      961 tggggtcccg cagccaagac agtgacctgg gtgccagagg cgtaggctca ttgccaccca
     1021 tgagggacaa actcctgctt gagaaaaacc tcaagaggct gctacgactg gaaagcaaag
     1081 ggaaagttct gaatcaacac tgctcccaga gggattccct gctatgggac tcactgggca
     1141 gccagagcag cagtcagccg acccgggaac agcccctgtc ttggttctct gggcttctgg
     1201 cctccacttc agtcacccct gaaacttcag agttgggact cggagaacaa gagatgattt
     1261 tcctcaaaca agaattaaac aaggagataa agtcactgct gaaccagcca acctccttca
     1321 acctgcctac ctattgtcca ctcagggaac cccatcgtac cctggatttc ctgtctgagc
     1381 accacctctt tccagccctg cagcgtgtgg tcagccaggc tgtagacaag ctgagccatg
     1441 cctgccgcca caatggcttc cccctcttcc ctgttacctc agagctgtct ccagtgtttc
     1501 ctgggaactc cgatcttcaa cccagctcta aggcttcctt acccaccgac agggaggcta
     1561 ggggagagac ttgttattct cccacctcgg cctccagccc taagacatct cacagaaaaa
     1621 gcaaggacag aaggggctcc ccatctaatg cagtccagat ggctaccaga ttcaggctca
     1681 agagccccaa caagtttttg aagaagaagg ccctgccctc catctcatcg gtgtccagct
     1741 tatcctacat ctctaacccc tggtttgagg aactcactaa cttcttggtt gagcaggcag
     1801 tctccttgct tatctgcaag tacaagtttg aggaaagcct caacaagcag cttggtttca
     1861 tctcctttcc gatcactgag gttctcatgg acatctttct gggcttcaag aaggtgaagg
     1921 gtacccacat ccgcctatct tcagacatca actggacctg tcttctgcgt aagttggagg
     1981 aagcagagat ggcgcggcag gccctgagac atgtctccag gtcaggaacc tctccacata
     2041 gcacctcccg tattgtcacc tcccaccata gcacaggacc ctcctctagg caaccagagc
     2101 ttactcgtga cacagatcag gaccagtctc cagagtccca cctctccctc caccctgcgt
     2161 tgccaatccg ccaggtgatg ggtcctcggg attctagaat aggccagaaa cagacagcaa
     2221 acacaaacca gtcagaggcc agacgctctg tgatttccac tgccggtatg ggctccaaga
     2281 ccaaggaagt ggtgaacatt gaagagggta aggacactga agaggaggag gaagaggaag
     2341 aggaagagga tgaggaggaa gaggatgagg aggaagagga tgaggaggag gatgaggagg
     2401 aagatgagga agaggaggag gaggaggaga gaggaagtga ggaggaagaa accaaggatt
     2461 tttctgagtg tgagcacgct cctagcccgc ctttgcatga attggagaac tctgtgaatg
     2521 agaccactat agtgagcccc ggtgactccc aatgagactt ctgtaagtca cgtggagtac
     2581 tccagtcctt ttctcctctt gttctatcca agtcgctggc cacccagcca gcccctgtcc
     2641 taagtggggg tcaggataac tgggtgctca ggaggagttc tgctaaagtt atcaagggag
     2701 ccaaagagac aaatggaaat aaattacgtg ttggtggaca ccgctg
//
LOCUS       NM_001437684            5038 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 4,
            mRNA.
ACCESSION   NM_001437684 XM_039087890
VERSION     NM_001437684.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5038)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5038)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 5038)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 5038)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 5038)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5038)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 5038)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 5038)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 5038)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 5038)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087890.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2283970.1,
                                           SRR26360176.886787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-441             JAXUCZ010000011.1  98104416-98104454
            442-488             JAXUCZ010000011.1  98105694-98105740
            489-560             JAXUCZ010000011.1  98106090-98106161
            561-647             JAXUCZ010000011.1  98108322-98108408
            648-810             JAXUCZ010000011.1  98109928-98110090
            811-931             JAXUCZ010000011.1  98113029-98113149
            932-1063            JAXUCZ010000011.1  98115531-98115662
            1064-1270           JAXUCZ010000011.1  98117537-98117743
            1271-1391           JAXUCZ010000011.1  98123938-98124058
            1392-1547           JAXUCZ010000011.1  98124251-98124406
            1548-1637           JAXUCZ010000011.1  98124558-98124647
            1638-1730           JAXUCZ010000011.1  98126328-98126420
            1731-1787           JAXUCZ010000011.1  98128415-98128471
            1788-1865           JAXUCZ010000011.1  98129086-98129163
            1866-2060           JAXUCZ010000011.1  98131039-98131233
            2061-2170           JAXUCZ010000011.1  98131384-98131493
            2171-2330           JAXUCZ010000011.1  98133415-98133574
            2331-5038           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..5038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5038
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2387
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 4 is encoded by transcript variant 4;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 4"
                     /protein_id="NP_001424613.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSK
                     GVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVN
                     LTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKI
                     SREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKS
                     VTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY
                     QSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHET
                     FGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRC
                     VELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAI
                     ELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEP
                     SPAASAEADGKVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPI
                     PIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPK
                     AVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQI
                     IAEIRETHLW"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    2094..2366
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2094..2366
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..488
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..560
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..810
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1063
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1547
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1637
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1730
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1787
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1865
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2060
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2170
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2330
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..5038
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gaaccctgct acatggaaaa
      421 actcaagaca cctttctaaa ggagttgaag cagaagaatg gggtaaattt cttcacacca
      481 aaaacaagct ttacacagat tttgatgaaa ttcgacaaga aattgaaaat gaaactgaaa
      541 gaatttcagg aaataataag ggagtaagcc ctgagccaat ccatctcaag gttttctcgc
      601 ccaacgttgt caacctgacg cttgtggatt taccaggaat gaccaaagta cctgtaggtg
      661 atcagcccaa ggatattgag cttcaaatca gagaacttat tcttcggttc atcagtaatc
      721 ccaattccat tatccttgct gtcactgctg caaatacaga tatggcaacg tcagaggcac
      781 ttaagatttc cagagaggta gatccagatg ggcgcagaac tctagctgta atcaccaagc
      841 ttgatctcat ggatgcgggt actgatgcca tggatgtatt gatgggaagg gttattccag
      901 tcaagcttgg aataattgga gtagttaaca ggagccaact ggacattaac aataagaaga
      961 gtgtaactga ttcaatccgt gatgagtatg cttttcttca aaagaagtac ccatctctgg
     1021 ccaacagaaa tggaacaaag tatcttgcta ggactctgaa taggttactt atgcatcata
     1081 tcagagactg tttaccagag ctgaaaacaa gaataaatgt cttagctgct cagtatcagt
     1141 ctcttctaaa tagctatggt gagcccgtgg atgataaaag tgctacttta ctccagctca
     1201 ttaccaagtt tgccacagag tattgtaaca ctattgaagg aacggcaaag tacattgaaa
     1261 cttctgagct atgtggtggt gctaggattt gttatatttt ccatgagact tttgggcgaa
     1321 ccttagaatc tgttgatcca ctaggtggcc ttaacactat tgacatcttg accgccatta
     1381 gaaatgctac tggcccccgt ccagctttat ttgtgcctga agtttcattt gagttactgg
     1441 tcaaacgtca gattaagcgt ctagaggagc ccagcctccg ctgtgtggag ctggtccacg
     1501 aggaaatgca gaggatcatt cagcactgta gcaactacag cacacaggaa ctgttacggt
     1561 tccctaaact ccatgatgcc atagttgaag tagtgacttg tcttcttcgt aaaaggttgc
     1621 ccgtgacaaa tgaaatggta cataacttag tggcaattga gctagcatat atcaacacaa
     1681 aacaccccga ctttgctgat gcctgtgggc taatgaacaa taacatagag gaacaaagaa
     1741 gaaacagact agcaagagaa ctaccttccg ctgtatcgcg agacaagtct tctaaagttc
     1801 caagtgcttt ggcacctgcc tcccaggagc cctcccctgc cgcttctgcc gaggctgatg
     1861 gcaaggttgc atctgcaggt ggtggaattg gagatggtgg tcgaattgga gatggtggtc
     1921 aggaaccgac aacaggcaac tggagaggaa tgctgaaaac ttcaaaagct gaagaattac
     1981 ttgctgaaga aaaatcaaaa ccaattccaa ttatgccagc aagtccacaa aaaggccatg
     2041 ctgtcaattt gctagatgtg ccagttccag ttgcacgaaa actgtctgcc cgagaacagc
     2101 gagattgtga ggttattgaa agactcatca aatcatattt tctaattgtc agaaagaata
     2161 ttcaagacag cgtcccaaag gcagtaatgc attttttggt taatcatgtg aaagatactc
     2221 ttcagagtga attagtaggg cagctgtata agtcatcctt attagatgac cttctgactg
     2281 aatccgagga catggcacag cgaagaaaag aagcggctga catgctgaag gcattacaag
     2341 gagccagtca aattattgct gaaatccgag agactcatct ttggtgaaca gaactgtttg
     2401 gtcttctaca ctttgctgac ttgaacctac tagctactgc ctacctgagt agaaatttat
     2461 ttatggactt ttgtgtatcg cagtgtatga atttgcttgt gtgaagactg gctataagct
     2521 gaaaagtata ttattcatta caagacaaat cacatgttta attcacattt ttcaagtttc
     2581 ctatgatgta tatcaagtct gtccgtttca gtcaaactta caagaacaat tgatgttcta
     2641 gttgtacaaa gcagtttgcc tgtgcatatg atgacctgcg taaccttttt ttagtcttaa
     2701 agctgcagcc gtagtcctca aagaggaagc tccaggacat ttcatgacta taatgcatgc
     2761 actatttata tagactgacc tggcttcaaa aggtggagcc tggcgagttc ctcacataat
     2821 caatgtatcc acctatcctt catttttata gtcttaaaaa acaaacaaaa ttctgaaact
     2881 tctgcagttt taggaaaaat ataagatctg aaagactcat aaagatgtag gaacagactg
     2941 tgtaattaat ggctcctgag tctatactgc cctaatgtta gaaagtaaaa tatgctttga
     3001 ttcaaaataa gcctgaaaat ataaattgac ttcctgcatt aaaaataact attaggaact
     3061 ttcttagtaa caataactgg tcctgttagt ttctaaatga ctcagtgaca acctaaattt
     3121 ccctaattta caagtacatc gattgcagtc cagatgcacc ttagggtggg gcgctgactc
     3181 tgggctccga gactcagtta tgtgagacct aaaagtctac tctgtatcca ctggtaatgc
     3241 tactttatag ttccacacca acagaataca tttgtcaaag aaaaatacct ggacatacac
     3301 atacacctaa aagcttatgg actactaaac tgtattcagg ggttgaggat ttacaaccta
     3361 ttttgtgaaa actgcctgtg caattcaatt tctgacctag ctgggcagtg gtggtgcaca
     3421 cctttaatcc cagcttttgg gaggcagagg caggtggatc tctgagttca aggccagcct
     3481 ggtctacaga gttgagttcc aagacaacca gaactacaca gagaaaccct gtcttgaacc
     3541 cccctccccc caaaaaattg aaacctaaat agaaatcttt gatgtatcta gttttctctg
     3601 accaaatgat acatttgtgt tataaatact aaaattcttt tcaggtcagg catcttatga
     3661 aatactatta gcaaggaaaa caagaacatg ttatctttag tttagatgcc cattgaacca
     3721 tctcaaaaac aaaggcagtc tgataacagt accagcttga cagtgagtat acactgccta
     3781 aatgtgttag catacttaag aaaaatatcc tgttatctaa ctattaggta tccatggttt
     3841 attttttaag agagatgacc accactgtag ccttttgaat ttgtaaagag aaagaatgca
     3901 cctttatcca acatttcaaa tagattttaa aaggaagatg ttagctttaa aaacgtgcta
     3961 tgataatgta cttgttagca ctacacactt tgtacaaaga aaaacaagca agaaaggtag
     4021 ggaaatgaaa gcttcctttg tgtactttta cactaagctg tgttctgaaa catggagata
     4081 atttataaga ccactgtatg ttctatgtaa ataaaaatgc tggtgtgaaa tggcattacg
     4141 gtttgccagt aagtgaattc ttcctgactt gccgtaagag agaggtttaa ataggtgcat
     4201 ctttgaaata tctgaatcta cttcataatg gaacgattta aattgtactg caccaaaagt
     4261 tttatgccat ttttttaatt agataatcac caccaaggcc ttgttacatc tttgtgtcta
     4321 cagatgaaga cagaaacttc ttccaagtaa tccaaggatg aatgctgaga acatgaactt
     4381 tgctgcaaga cgtctagaag ctgatccaca gtttatgttt cacccctatg tacattgggg
     4441 tggtgctatc ttgattttta cagaaactgt ttttgagaat tagcttgcct tgtgtataca
     4501 aacctgaact agtttgactt caaaacttcc tgtatctttt ctgttcttac tgactgcata
     4561 cttgatgaga tactttttgt ttctttggtt tcttaaaata tctgctatag gaacccactg
     4621 gcaaaaatag gcagttatca gtaaattatt gaaacacaga acaaggaagt ggaaaactga
     4681 actataaatg aagtctggta ctgattgatg ttttgtttta agaaaaaact attttgtact
     4741 acagtttcta ttgggaacca ctgccatatc taactccttt ttaagaattc tgtttgcttg
     4801 gcagcatcaa tcagaagttt aactttgtaa cagatttctc acatctaaac agacattaga
     4861 agcttggcca gtttgtacag ctatgtaaca caactgcaat caggtgctta ccttacctcc
     4921 tgtgttaact ttatacagtc atttccactg caccacttct tcagaccaag gagcaagaaa
     4981 gatcattctt gcataaagaa atgaactata attaaatatc actttatttt gaaatgca
//
LOCUS       NM_001437682            5071 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 2,
            mRNA.
ACCESSION   NM_001437682 XM_039087888
VERSION     NM_001437682.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5071)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 5071)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 5071)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 5071)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 5071)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5071)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 5071)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 5071)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 5071)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 5071)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087888.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.67895.1,
                                           SRR26360194.2130931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000011.1  98085425-98085660
            237-402             JAXUCZ010000011.1  98101064-98101229
            403-441             JAXUCZ010000011.1  98104416-98104454
            442-488             JAXUCZ010000011.1  98105694-98105740
            489-560             JAXUCZ010000011.1  98106090-98106161
            561-647             JAXUCZ010000011.1  98108322-98108408
            648-810             JAXUCZ010000011.1  98109928-98110090
            811-931             JAXUCZ010000011.1  98113029-98113149
            932-1063            JAXUCZ010000011.1  98115531-98115662
            1064-1270           JAXUCZ010000011.1  98117537-98117743
            1271-1391           JAXUCZ010000011.1  98123938-98124058
            1392-1547           JAXUCZ010000011.1  98124251-98124406
            1548-1637           JAXUCZ010000011.1  98124558-98124647
            1638-1730           JAXUCZ010000011.1  98126328-98126420
            1731-1787           JAXUCZ010000011.1  98128415-98128471
            1788-1865           JAXUCZ010000011.1  98129086-98129163
            1866-1898           JAXUCZ010000011.1  98129443-98129475
            1899-2093           JAXUCZ010000011.1  98131039-98131233
            2094-2203           JAXUCZ010000011.1  98131384-98131493
            2204-2363           JAXUCZ010000011.1  98133415-98133574
            2364-5071           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..5071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..5071
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2420
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 2"
                     /protein_id="NP_001424611.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSK
                     GVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVN
                     LTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKI
                     SREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKS
                     VTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY
                     QSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHET
                     FGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRC
                     VELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAI
                     ELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEP
                     SPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAE
                     ELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLI
                     VRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAAD
                     MLKALQGASQIIAEIRETHLW"
     misc_feature    135..137
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    201..1097
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin_like protein family includes dynamins and
                     Mx proteins; Region: DLP_1; cd08771"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    228..251
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G1 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(231..233,237..254,291..296,309..311,627..629,
                     837..839,843..848,924..938,945..947)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    order(234..239,639..641,678..680,753..755,759..761,
                     765..776,780..785,846..848,852..863,933..941)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:206738"
     misc_feature    306..314
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    309..311
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G2 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    321..329
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    627..638
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G3 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    order(633..638,726..731)
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    834..845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G4 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    864..1721
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    924..935
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01055"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    924..932
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="G5 box; other site"
                     /db_xref="CDD:206738"
     misc_feature    1221..1658
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Middle domain.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1533..2264
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Interaction with GSK3B.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1695..1898
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: B domain. /evidence=ECO:0000250|UniProtKB:O00429"
     misc_feature    1758..1982
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1776..1778
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1833..1835
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    1962..1964
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1965..1967
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:22745122; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); glycosylation site"
     misc_feature    1998..2000
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q8K1M6; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); acetylation site"
     misc_feature    2028..2030
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00429; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2055..2057
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:17301055,
                     ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2118..2120
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Phosphoserine, by CAMK1 and PKA.
                     /evidence=ECO:0000269|PubMed:28463107; propagated from
                     UniProtKB/Swiss-Prot (O35303.1); phosphorylation site"
     misc_feature    2127..2399
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2127..2399
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    2169..2213
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35303.1);
                     Region: Important for homodimerization.
                     /evidence=ECO:0000250|UniProtKB:O00429"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..488
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..560
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..810
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1063
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1270
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1547
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1637
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1730
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1787
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1865
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1898
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2093
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2203
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2363
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..5071
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtggcgg cctagcccaa tgggtgcgtg ctcccgagga gagggcggag gagaaaagga
       61 agcaagcggg ctgcgggctg cgtccccatt cattgcagtg gtctgctggg ttggggtcca
      121 gtgtttccgg agtcatggag gcgctgatcc cggtcatcaa taagctgcaa gacgtcttca
      181 acaccgtggg cgccgacatc atccagctgc ctcagattgt cgtagtggga actcagagca
      241 gtggaaagag ctcagtgctg gaaagcctag tggggaggga ccttcttccc agagggactg
      301 gtgtggtcac ccggagacct cttattctgc agctggtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gaaccctgct acatggaaaa
      421 actcaagaca cctttctaaa ggagttgaag cagaagaatg gggtaaattt cttcacacca
      481 aaaacaagct ttacacagat tttgatgaaa ttcgacaaga aattgaaaat gaaactgaaa
      541 gaatttcagg aaataataag ggagtaagcc ctgagccaat ccatctcaag gttttctcgc
      601 ccaacgttgt caacctgacg cttgtggatt taccaggaat gaccaaagta cctgtaggtg
      661 atcagcccaa ggatattgag cttcaaatca gagaacttat tcttcggttc atcagtaatc
      721 ccaattccat tatccttgct gtcactgctg caaatacaga tatggcaacg tcagaggcac
      781 ttaagatttc cagagaggta gatccagatg ggcgcagaac tctagctgta atcaccaagc
      841 ttgatctcat ggatgcgggt actgatgcca tggatgtatt gatgggaagg gttattccag
      901 tcaagcttgg aataattgga gtagttaaca ggagccaact ggacattaac aataagaaga
      961 gtgtaactga ttcaatccgt gatgagtatg cttttcttca aaagaagtac ccatctctgg
     1021 ccaacagaaa tggaacaaag tatcttgcta ggactctgaa taggttactt atgcatcata
     1081 tcagagactg tttaccagag ctgaaaacaa gaataaatgt cttagctgct cagtatcagt
     1141 ctcttctaaa tagctatggt gagcccgtgg atgataaaag tgctacttta ctccagctca
     1201 ttaccaagtt tgccacagag tattgtaaca ctattgaagg aacggcaaag tacattgaaa
     1261 cttctgagct atgtggtggt gctaggattt gttatatttt ccatgagact tttgggcgaa
     1321 ccttagaatc tgttgatcca ctaggtggcc ttaacactat tgacatcttg accgccatta
     1381 gaaatgctac tggcccccgt ccagctttat ttgtgcctga agtttcattt gagttactgg
     1441 tcaaacgtca gattaagcgt ctagaggagc ccagcctccg ctgtgtggag ctggtccacg
     1501 aggaaatgca gaggatcatt cagcactgta gcaactacag cacacaggaa ctgttacggt
     1561 tccctaaact ccatgatgcc atagttgaag tagtgacttg tcttcttcgt aaaaggttgc
     1621 ccgtgacaaa tgaaatggta cataacttag tggcaattga gctagcatat atcaacacaa
     1681 aacaccccga ctttgctgat gcctgtgggc taatgaacaa taacatagag gaacaaagaa
     1741 gaaacagact agcaagagaa ctaccttccg ctgtatcgcg agacaagtct tctaaagttc
     1801 caagtgcttt ggcacctgcc tcccaggagc cctcccctgc cgcttctgcc gaggctgatg
     1861 gcaagttaat tcaggacaac agaagagaaa ctaaaaatgt tgcatctgca ggtggtggaa
     1921 ttggagatgg tggtcgaatt ggagatggtg gtcaggaacc gacaacaggc aactggagag
     1981 gaatgctgaa aacttcaaaa gctgaagaat tacttgctga agaaaaatca aaaccaattc
     2041 caattatgcc agcaagtcca caaaaaggcc atgctgtcaa tttgctagat gtgccagttc
     2101 cagttgcacg aaaactgtct gcccgagaac agcgagattg tgaggttatt gaaagactca
     2161 tcaaatcata ttttctaatt gtcagaaaga atattcaaga cagcgtccca aaggcagtaa
     2221 tgcatttttt ggttaatcat gtgaaagata ctcttcagag tgaattagta gggcagctgt
     2281 ataagtcatc cttattagat gaccttctga ctgaatccga ggacatggca cagcgaagaa
     2341 aagaagcggc tgacatgctg aaggcattac aaggagccag tcaaattatt gctgaaatcc
     2401 gagagactca tctttggtga acagaactgt ttggtcttct acactttgct gacttgaacc
     2461 tactagctac tgcctacctg agtagaaatt tatttatgga cttttgtgta tcgcagtgta
     2521 tgaatttgct tgtgtgaaga ctggctataa gctgaaaagt atattattca ttacaagaca
     2581 aatcacatgt ttaattcaca tttttcaagt ttcctatgat gtatatcaag tctgtccgtt
     2641 tcagtcaaac ttacaagaac aattgatgtt ctagttgtac aaagcagttt gcctgtgcat
     2701 atgatgacct gcgtaacctt tttttagtct taaagctgca gccgtagtcc tcaaagagga
     2761 agctccagga catttcatga ctataatgca tgcactattt atatagactg acctggcttc
     2821 aaaaggtgga gcctggcgag ttcctcacat aatcaatgta tccacctatc cttcattttt
     2881 atagtcttaa aaaacaaaca aaattctgaa acttctgcag ttttaggaaa aatataagat
     2941 ctgaaagact cataaagatg taggaacaga ctgtgtaatt aatggctcct gagtctatac
     3001 tgccctaatg ttagaaagta aaatatgctt tgattcaaaa taagcctgaa aatataaatt
     3061 gacttcctgc attaaaaata actattagga actttcttag taacaataac tggtcctgtt
     3121 agtttctaaa tgactcagtg acaacctaaa tttccctaat ttacaagtac atcgattgca
     3181 gtccagatgc accttagggt ggggcgctga ctctgggctc cgagactcag ttatgtgaga
     3241 cctaaaagtc tactctgtat ccactggtaa tgctacttta tagttccaca ccaacagaat
     3301 acatttgtca aagaaaaata cctggacata cacatacacc taaaagctta tggactacta
     3361 aactgtattc aggggttgag gatttacaac ctattttgtg aaaactgcct gtgcaattca
     3421 atttctgacc tagctgggca gtggtggtgc acacctttaa tcccagcttt tgggaggcag
     3481 aggcaggtgg atctctgagt tcaaggccag cctggtctac agagttgagt tccaagacaa
     3541 ccagaactac acagagaaac cctgtcttga acccccctcc ccccaaaaaa ttgaaaccta
     3601 aatagaaatc tttgatgtat ctagttttct ctgaccaaat gatacatttg tgttataaat
     3661 actaaaattc ttttcaggtc aggcatctta tgaaatacta ttagcaagga aaacaagaac
     3721 atgttatctt tagtttagat gcccattgaa ccatctcaaa aacaaaggca gtctgataac
     3781 agtaccagct tgacagtgag tatacactgc ctaaatgtgt tagcatactt aagaaaaata
     3841 tcctgttatc taactattag gtatccatgg tttatttttt aagagagatg accaccactg
     3901 tagccttttg aatttgtaaa gagaaagaat gcacctttat ccaacatttc aaatagattt
     3961 taaaaggaag atgttagctt taaaaacgtg ctatgataat gtacttgtta gcactacaca
     4021 ctttgtacaa agaaaaacaa gcaagaaagg tagggaaatg aaagcttcct ttgtgtactt
     4081 ttacactaag ctgtgttctg aaacatggag ataatttata agaccactgt atgttctatg
     4141 taaataaaaa tgctggtgtg aaatggcatt acggtttgcc agtaagtgaa ttcttcctga
     4201 cttgccgtaa gagagaggtt taaataggtg catctttgaa atatctgaat ctacttcata
     4261 atggaacgat ttaaattgta ctgcaccaaa agttttatgc cattttttta attagataat
     4321 caccaccaag gccttgttac atctttgtgt ctacagatga agacagaaac ttcttccaag
     4381 taatccaagg atgaatgctg agaacatgaa ctttgctgca agacgtctag aagctgatcc
     4441 acagtttatg tttcacccct atgtacattg gggtggtgct atcttgattt ttacagaaac
     4501 tgtttttgag aattagcttg ccttgtgtat acaaacctga actagtttga cttcaaaact
     4561 tcctgtatct tttctgttct tactgactgc atacttgatg agatactttt tgtttctttg
     4621 gtttcttaaa atatctgcta taggaaccca ctggcaaaaa taggcagtta tcagtaaatt
     4681 attgaaacac agaacaagga agtggaaaac tgaactataa atgaagtctg gtactgattg
     4741 atgttttgtt ttaagaaaaa actattttgt actacagttt ctattgggaa ccactgccat
     4801 atctaactcc tttttaagaa ttctgtttgc ttggcagcat caatcagaag tttaactttg
     4861 taacagattt ctcacatcta aacagacatt agaagcttgg ccagtttgta cagctatgta
     4921 acacaactgc aatcaggtgc ttaccttacc tcctgtgtta actttataca gtcatttcca
     4981 ctgcaccact tcttcagacc aaggagcaag aaagatcatt cttgcataaa gaaatgaact
     5041 ataattaaat atcactttat tttgaaatgc a
//
LOCUS       NM_001437723            8394 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus histone deacetylase 4 (Hdac4), transcript variant
            2, mRNA.
ACCESSION   NM_001437723 XM_006245438
VERSION     NM_001437723.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8394)
  AUTHORS   Gu,X., Li,F., Che,X., Wei,X. and Li,P.
  TITLE     HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model
  JOURNAL   BMC Musculoskelet Disord 25 (1), 467 (2024)
   PUBMED   38879481
  REMARK    GeneRIF: HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8394)
  AUTHORS   Zhang,D., Du,J., Yu,M. and Suo,L.
  TITLE     Urine-derived stem cells-extracellular vesicles ameliorate diabetic
            osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering
            microRNA-26a-5p
  JOURNAL   Cell Biol Toxicol 39 (5), 2243-2257 (2023)
   PUBMED   35554780
  REMARK    GeneRIF: Urine-derived stem cells-extracellular vesicles ameliorate
            diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by
            delivering microRNA-26a-5p.
REFERENCE   3  (bases 1 to 8394)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7. PMID: 36806965]
REFERENCE   4  (bases 1 to 8394)
  AUTHORS   Moreno-Ruperez,A., Priego,T., Gonzalez-Nicolas,M.A.,
            Lopez-Calderon,A., Lazaro,A. and Martin,A.I.
  TITLE     Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm
            and Gastrocnemius Proteolytic Activity in Septic Rats
  JOURNAL   Int J Mol Sci 23 (7), 3641 (2022)
   PUBMED   35408999
  REMARK    GeneRIF: Role of Glucocorticoid Signaling and HDAC4 Activation in
            Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8394)
  AUTHORS   Wei,W., Chen,W. and He,N.
  TITLE     HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation
  JOURNAL   J Transl Med 19 (1), 258 (2021)
   PUBMED   34118928
  REMARK    GeneRIF: HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8394)
  AUTHORS   Fischle,W., Dequiedt,F., Hendzel,M.J., Guenther,M.G., Lazar,M.A.,
            Voelter,W. and Verdin,E.
  TITLE     Enzymatic activity associated with class II HDACs is dependent on a
            multiprotein complex containing HDAC3 and SMRT/N-CoR
  JOURNAL   Mol Cell 9 (1), 45-57 (2002)
   PUBMED   11804585
REFERENCE   7  (bases 1 to 8394)
  AUTHORS   Lu,J., McKinsey,T.A., Zhang,C.L. and Olson,E.N.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   8  (bases 1 to 8394)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   9  (bases 1 to 8394)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 8394)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006245438.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.34725.1,
                                           SRR26643295.36383.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000009.1  100197301-100197601 c
            302-540             JAXUCZ010000009.1  100164705-100164943 c
            541-612             JAXUCZ010000009.1  100076183-100076254 c
            613-854             JAXUCZ010000009.1  100050680-100050921 c
            855-1005            JAXUCZ010000009.1  100034333-100034483 c
            1006-1126           JAXUCZ010000009.1  100024695-100024815 c
            1127-1248           JAXUCZ010000009.1  100018481-100018602 c
            1249-1380           JAXUCZ010000009.1  100013993-100014124 c
            1381-1493           JAXUCZ010000009.1  100010352-100010464 c
            1494-1610           JAXUCZ010000009.1  100007494-100007610 c
            1611-1809           JAXUCZ010000009.1  100007207-100007405 c
            1810-2048           JAXUCZ010000009.1  100004898-100005136 c
            2049-2303           JAXUCZ010000009.1  99998890-99999144   c
            2304-2490           JAXUCZ010000009.1  99996052-99996238   c
            2491-2624           JAXUCZ010000009.1  99994292-99994425   c
            2625-2745           JAXUCZ010000009.1  99991723-99991843   c
            2746-2792           JAXUCZ010000009.1  99988140-99988186   c
            2793-2900           JAXUCZ010000009.1  99984745-99984852   c
            2901-2956           JAXUCZ010000009.1  99982715-99982770   c
            2957-3044           JAXUCZ010000009.1  99981864-99981951   c
            3045-3164           JAXUCZ010000009.1  99979516-99979635   c
            3165-3262           JAXUCZ010000009.1  99978680-99978777   c
            3263-3381           JAXUCZ010000009.1  99971610-99971728   c
            3382-3515           JAXUCZ010000009.1  99970072-99970205   c
            3516-3600           JAXUCZ010000009.1  99956805-99956889   c
            3601-3742           JAXUCZ010000009.1  99955846-99955987   c
            3743-8394           JAXUCZ010000009.1  99950972-99955623   c
FEATURES             Location/Qualifiers
     source          1..8394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..8394
                     /gene="Hdac4"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
     exon            1..301
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    63..65
                     /gene="Hdac4"
                     /note="upstream in-frame stop codon"
     exon            302..540
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..3782
                     /gene="Hdac4"
                     /EC_number="3.5.1.98"
                     /note="isoform 2 is encoded by transcript variant 2; HD4"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 2"
                     /protein_id="NP_001424652.1"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     AAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ
                     HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG
                     KESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQS
                     GVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVA
                     TALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVT
                     REGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHL
                     TPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTDWYLSGLGALPLHTQSLVGA
                     DRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHL
                     SKMISKPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPI
                     ESEEEEVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSF
                     GSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHA
                     GRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKK
                     LLGSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFA
                     VVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYN
                     DPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF
                     RTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIV
                     LALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEY
                     WRCLQRLSPTVGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
     misc_feature    <786..971
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    <786..971
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    order(792..794,804..806,837..842,849..851,870..872,
                     882..887)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(792..794,804..806,837..842,849..851,870..872,
                     882..887)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    867..1454
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Interaction with MEF2A. /evidence=ECO:0000250"
     misc_feature    912..1019
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1128..1193
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1143..1145
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZM9; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1233..1499
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1251..1253
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1560..1577
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: PxLPxI/L motif, mediates interaction with ANKRA2
                     and 14-3-3 proteins.
                     /evidence=ECO:0000250|UniProtKB:P56524"
     misc_feature    1563..1565
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1929..1931
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2055..2123
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2157..2279
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2220..2222
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2400..2471
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2421..2423
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2424..2426
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2472..3698
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    2472..3698
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    order(2931..2936,2958..2963,3045..3047,3051..3053,
                     3327..3329,3447..3449)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    order(2931..2936,2958..2963,3045..3047,3051..3053,
                     3327..3329,3447..3449)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    3678..3779
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Nuclear export signal. /evidence=ECO:0000250"
     misc_feature    3702..3779
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            541..612
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..854
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1005
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1126
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1248
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1380
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1493
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1610
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1809
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2048
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2303
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2490
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2624
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2745
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2792
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2900
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..2956
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3044
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3164
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3262
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3381
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3515
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3600
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3742
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..8394
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggctct gcgctcgagg gggagcagca tcatggttca acgtgggtca attttttgtg
       61 aatgaggagg ggaggttgtg gggccgctgc cgcggagcac catccccgcc gccgcccgag
      121 cccgagcccg cgcgcctgct cgcgccgccg ccgtcgccgc gccgcctcac gcccggcccg
      181 ctcaacgcga ctgctgtcgc cgtcgccgcc cgagcccgcc cgcccgccgg cggcggcgca
      241 ggctgaggag atgcggctcg gagcgcccga gcagggctag acgcggcccg ccgccgccgc
      301 ggttcatctc tgcaaggcca ggtgacaact tctgctcttc ttgtggatta cttggtttac
      361 aagacgctgc cagtgggact tcgagtttgc gcagctggga cccgggcctc ctcagttttg
      421 tacctgcatg ttctcgtggg aatttggagc gtgttggagc cactgtttac ctggacatct
      481 tgagccattt cgaacttaag gcactgacgc tgctagcaat gagctcccaa agccatccag
      541 atggactttc tggccgagac cagcctgtgg agctgctgaa tcctgcccgc gtgaaccaca
      601 tgcccagcac ggtggacgtg gctacagcgc tgcctctgca ggtggcccct gcagcagtac
      661 ccatggacct gcgcttggac caccagttct cactgccctt ggaacctgca ctgcgggagc
      721 agcaactgca gcaggaactc ctagcactga agcagaagca gcagatccag cggcagatcc
      781 tcattgcaga gttccagcgt cagcatgagc agttgtcccg acagcatgag gcacagctgc
      841 atgaacatat caagcagcag caggagatgc tggccatgaa gcaccagcag gagctgctgg
      901 agcaccagcg gaaactggag cggcaccggc aagagcagga gctggagaag cagcaccgtg
      961 agcagaagct gcagcagctc aagaacaagg agaagggcaa agagagtgct gtggcgagca
     1021 cagaggtgaa gatgaagctg caggagtttg ttctcaacaa gaagaaggct ctggcccacc
     1081 ggaacctgaa ccactgcatg tccagcgacc cccgctactg gtatgggaag acacagcaca
     1141 gctcccttga ccagagctct ccaccccaga gtggggtgtc agcctcctac aaccaccctg
     1201 tcttgggaat gtacgacgcc aaagatgact tccctcttag gaaaacagct tctgaaccta
     1261 acctgaaatt acggtcaagg cttaagcaga aagtagctga gagacggagc agccccctgc
     1321 tgcgcaggaa agatggccct gtggccactg ctctaaaaaa gcgacccctg gatgttacag
     1381 actccgcatg tagcagcgcc cctggctccg gtcccagctc ccccaatagc agctctggca
     1441 acgtcagcac cgagaatggc attgcaccca ccgtgcccag cactccagct gagacgagct
     1501 tggcacacag acttgtgact cgagaaggct ctgttgcccc acttcctctc tatacatcac
     1561 catccttgcc caacatcacc ctgggacttc ctgccactgg ccctgctgct ggtgcagcag
     1621 gccagcagga tgctgagagg cttgctctcc cagccctcca gcagcgaatc tccttgttcc
     1681 ctgggaccca cctcacccca tacctgagca cctcgcccct ggagcgggac ggtggagcag
     1741 ctcacaaccc cctcctgcag cacatggtcc tgctggagca gccacccacc cagacgcccc
     1801 ttgtcacaga ctggtatctt tcaggcctgg gggcactgcc cctccacaca cagtccctgg
     1861 ttggtgcgga cagggtgtcc ccatccattc acaagctgcg gcagcaccga cctctggggc
     1921 gcacgcagtc agcacccctg ccgcagaacg cacaggccct gcagcacctg gtgatccagc
     1981 agcagcacca gcagtttctg gagaagcaca agcaacagtt ccagcagcag cagctgcacc
     2041 tcagcaagat gatttctaaa cccagtgagc cacctcggca gcctgagagc cacccggagg
     2101 agacagagga ggagctccgt gaacaccagg ccttgctgga tgagccctac ctagatcggc
     2161 tccctgggca gaaggagccc tccttagctg gtgtgcaggt gaagcaggag cccatcgaga
     2221 gtgaggagga agaagtagag gccactcgag aggcggaacc cagccagcgc ccagccactg
     2281 aacaggagct tctctttaga cagcaagctc ttctgctgga gcagcagagg atccaccagt
     2341 taaggaacta ccaggcatct atggaggctg ctggcatccc tgtgtcattt ggcagccaca
     2401 gacctctgtc tcgcgcacag tcctccccag catctgccac cttccccatg tcagtccagg
     2461 agccccccac caaaccaagg ttcaccacag gccttgtgta tgacacactc atgttgaagc
     2521 accagtgcac ctgtgggaac accaacagcc acccggagca tgctgggagg atccagagca
     2581 tctggtcccg cctgcaggag actggcctcc gtggcaagtg tgagtgcatc cgcggacgca
     2641 aggccacact ggaagagctg cagacagtgc actcggaggc ccacacactc ctctatggca
     2701 caaaccctct caacagacag aaactggaca gtaagaaact tctaggctcg ctgacctccg
     2761 tgtttgtcag gcttccttgt ggtggtgttg gggtggatag tgataccata tggaatgagg
     2821 tgcactcgtc tggggcagcc cgcctggctg taggctgtgt agtggagctg gtcttcaagg
     2881 tggccacggg agagctaaag aatggctttg ctgtggttcg tcccccagga caccatgccg
     2941 aggagagtac acccatgggt ttctgctact ttaattctgt ggcaattgca gccaaacttc
     3001 tccagcagag gttgaatgtg agcaagatcc tcattgtaga ctgggatgtg caccatggga
     3061 atgggaccca gcaggccttc tacaatgacc ccaatgttct ctacatgtcc ctgcaccgct
     3121 atgacgatgg gaacttcttc ccaggaagtg gagcaccaga tgaggtgggc acagggccag
     3181 gcgtgggttt caatgtcaac atggccttca cgggtggcct cgatcccccc atgggagacg
     3241 ccgagtacct ggcagccttc agaacggtgg tcatgccaat cgcaaatgag tttgccccag
     3301 atgtggtact ggtgtcctcg ggcttcgatg ctgtggaggg ccaccccaca cctcttggag
     3361 ggtacaatct ctctgccaaa tgtttcgggt acttgacaaa acagctgatg ggcttagctg
     3421 gtggccggat cgtgctggcc ctggagggag gccatgacct gacagccatc tgtgatgctt
     3481 ctgaagcatg tgtttctgct ctgctgggaa atgagcttga gcctctgcca gaaaaggttc
     3541 tacatcagag acccaatgcc aatgccgtcc actccatgga gaaagtgatg ggcatccaca
     3601 gtgagtactg gcgctgcctg cagcgtttgt cccccactgt ggggcactct ctgattgagg
     3661 cgcagaagtg tgagaatgaa gaagctgaga cagtcaccgc catggcctcg ctgtctgtag
     3721 gcgtcaaacc tgctgagaag agatctgagg aggagcccat ggaggaggag ccaccactgt
     3781 agccgaagct gctgttctct cctttgtctg tctgtcttaa ggctcagcca agaaactttc
     3841 ccgtgtcact cctgcgtcct gccttggtgc tctctctgag tgcgaaggga cagcaggtgt
     3901 gaagcagcaa cgggaggcct ttctgccgcc ctggaccaca ggtctggaga cgcacacgaa
     3961 caccaggtgt ggcagatcag atggaacaca ggacagtgcg caacacgtgg gcacacagac
     4021 atgccgcaga agccaagcac acgctgctgg ggtcccccag gaaagccacg aaggaagaag
     4081 cttgtggcaa cttgggcaga gttgctgaat tgagttgaca tgaggaaaat gaaaatcaaa
     4141 gatctaataa tacagaacaa acttgattaa aactggtgct taacatttga ttcttaccca
     4201 caatcccaca gtctccgtgt aaaccactca actcatcttg tagctttttt aaaaaaaaaa
     4261 aaaaacaaga aaacaaaaca gttttctatg gctctggcct gccttgtgaa ccttagtggg
     4321 gtgctgtggg ggttcacagc ttagcgagga cggagttgga agaaacgtca aagaataaaa
     4381 aactagacag aacagaaatg ggagcctggg agtcagctgg agcttctcga agccatcgga
     4441 agatgcgagt ttgtgccttt ttttattgct ctgatggaat tttttgtggc tgggttttct
     4501 gaagtctgag gaacaatgcc ttaagaaaaa acaaaaacaa aaacaaaaaa acaccagtaa
     4561 gaattggtgt gacagtgtcc tgtggctggc tgagtctagt gatgctggcc tggcattaca
     4621 agagtggcac cagccactgt ccccgagggc cgaaggacag ccagccagcc ttgcttggtt
     4681 tgatcaccgt ttaaggaagg tgaggtagtt ccaaaaagca gcgaacgccg ccgccgccgg
     4741 cagttttgaa gtctaacacg tttttaaacg gatccaaagt gttctttcct catccgtcac
     4801 atagcagttg agcatctcca ttcgattgtg aagcatgtcg taggcacatt gcagtgttac
     4861 gatcggaatg cttttcatta aaagcaggta gcatgaagta ttgcttaaat tttaggtata
     4921 aataaatata tatatatatg tataatatat attccactgt attccaagct aagaaacttg
     4981 attcttatga gatcttgata aaatatttat aatgcattta tagacaaagt atatataaat
     5041 atatataata aatccagacc gcagaggtcc tggcaggcga aagacgtgtg tgttagctct
     5101 gaggtgctga gggctgggtc tggattgaag cccatggatt tctgagctcc agattggcca
     5161 gcttccagat tgccagcatg ttcacccctg ggcaatttcc ctaccagttt gtactttaat
     5221 tttaattatt ttctaacaaa acctctgccc tttccaagcc tccatgcaca tatgtacctg
     5281 atgagttttt atagcaaaag atataaactt gctgttgatt tttgtatgaa tttttcacaa
     5341 aaagatcctg aagaaaacat tattttgtgg attttacatt tttcccctta ccattcagca
     5401 gttttctgaa ggtggtaatg tctgaaactt tttctttcta aattcttact tgtacatttt
     5461 ttttagctct gaaggttatt tttatggttt gattttgttt ctttttgtac agcaagcagg
     5521 gctctgcttt gaccaggacc gctgctgtca tgcttggttt tttagagcaa acctctcgag
     5581 attgggcagc aggtctgcgt ggcacccttg tcttgtaaag ctcaccggga gctgcacagc
     5641 cacgggctcc tgccccgcaa cactcatagt attacaaggg cgggcaggcc gcatgagaca
     5701 cgagggcagt cagcatcaat gagcgtggac ttgtaaccac tccatcagga tagaactcca
     5761 gctctagttt cccaaagacc ttcgaggcga gtccacaagc gcctgcccag agcctggccc
     5821 tgcagctgtc agcaatttcc attgcggcct cataacctgg actctggcta gagccacagc
     5881 cctgggtttg tagcctgtgg ctgctgaacc aaggcctttg tccttgtcct gcaggaacac
     5941 atagggtcct gagggacagt cagtctttgt ctttgctctt ttttttttct atgacaactg
     6001 actttttaac tgctaacttc ttttctagca cttaaagcca ccaatttcat tccaaagtgg
     6061 agttcagact ggcgagagga agttgagata ctcagaaggg acatcaagct aagtttctga
     6121 atttggtggc atttacaggg tagatgggaa ctgggtcaag cttttaacca acaggctgaa
     6181 cacacattct tggacttttg atcgctgtgc tgctatgagt gctaagctaa gacagtgggt
     6241 agagaggtct taggacatgc ctgactgtcc tccctgtgtc ccttctggcc cttggcggaa
     6301 gggacaaact tgagggagcc atgcagcctc tcccttgctt gtcactgcat ggtgacagag
     6361 gccagctagc tgctcttctg gcctccttgg tccattttct gcataccctg ccacctgccc
     6421 tcttgtgcca gccacgactc gtgggagcat catcttacct tttcaggtga tgggtagcag
     6481 gccactcagt ggccagggta ctgtgagagg aactcacttt ggttctattc agtcaccctt
     6541 tgatgcaggg gcctggccag ggagccagct cactccagct tccctgggag ctgaaagcat
     6601 tacctaccat atagcctttt ctcccctttg aagacaggtg tggtccttcc tcacagtcat
     6661 cacccagggc agagggcaga aggtcggcct tgacctccag ggcaggacca cagcactccc
     6721 ctgcctggac cttgaacctt ccaccttctc ccttcctttg caaaggcctt ggtgggtgct
     6781 ggcaagggag ccggagcaag cactttacac ccctttaagg ggagcccgaa ggcaccgtgt
     6841 cctcagggtg ctggtgttcg ctcacccttg gggcttccac ctgcaccctg agagcccacg
     6901 ccccaccagc aggcggctgt tcccaaggcc accacctgct gggacatccc agggctctgg
     6961 cttgagggct gctttatgaa agtgtttcag tttttcttta ttttcaaatc tgtccccaag
     7021 aggaaggacc accctgtggt ggtctccgca gcactggtga tgggctcagt catgtttctt
     7081 tcctcagaac attccttcct tcttcactgg tcccagccac gtgctcattc catccttctt
     7141 tttgtagact ttgggcccat gtattttatg ggcattgata catatataaa tatatagata
     7201 taaatatata aatatatttt tttaagtttc ctacacctgg aggttgcatg gacgtacgcc
     7261 ggcatgtctt tatattgtat acagattttg cacgccaaac tcggcagctt tggggaagga
     7321 gaagcattgc ctttctctcc cctctcatga tgtttgcaga tgcagaaatt tttttctgta
     7381 aaacaaaaca aaaccttgaa ggagaagagg ggggcgtttg agtcttactg aacttattct
     7441 taagaaattg tactttttat tgtaagaaaa ataaaaggac tacttccaca ctcgtcatta
     7501 agaaaagttt acctagcacc tttgacatac cgatagagag tcgattgtat ccacacgcaa
     7561 gctccacatt cagaccctgc tgcctgtctg tcaagctggc tgggggtgtt ttcttttgtt
     7621 ttgttggttt tctcctctct ctccccgcac agggccaggt gcaccctgcc tgctgtcact
     7681 ggcctctggt cgagaacctg aggttctggt gagtcctgtc tcagcacaac tgtgtcgatg
     7741 ggttcattcc ttctagaaga cacggggctg gggttctgca ctgggcaatc caggcctttg
     7801 tgagccctag gtctaaatga cacttggcac tggaggaaac tatttctccc tctcaaggat
     7861 ccaggtgtgc tctgcacccg gccttgatgg cctcaccggc cttgagttga tcaaagtcta
     7921 ctatggaaag agaagaatgc agacaggcct tgttcggggg tgtgcactcc agtgaggagg
     7981 taccgtttcc cgatctgtaa gaatgttaaa catgctgttt tcatgtatgc acaggaggct
     8041 gacctctgtc agcaagagct cactacagaa gtgtggtcca agccaccgga gcgctgccac
     8101 atgatgccgt gtgtgctcca cagccttgac cgccttcact ctgtaacagc ctgttttctc
     8161 tttgattgtc tggacctccc ctccttggcg ctttctcctc ctggcggggt tgggggtcat
     8221 gtttggtttt ctcattcttg tttcgttttt ttttttgtgt gtgtggtggg tttcactgac
     8281 cggcggtgcc ctctggcggt cacctctttc cacctcccgg gtccagtgtt tgtaccacat
     8341 cacacacttg tcgctctcgt ggtgtaaata aagactgcgt taattgccct ccca
//
LOCUS       NM_001437749            4173 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 9 member C1 (Slc9c1),
            transcript variant 3, mRNA.
ACCESSION   NM_001437749 XM_017597926
VERSION     NM_001437749.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4173)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   2  (bases 1 to 4173)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_017597926.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.69079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000011.1  68740607-68740859   c
            254-384             JAXUCZ010000011.1  68739393-68739523   c
            385-638             JAXUCZ010000011.1  68738514-68738767   c
            639-739             JAXUCZ010000011.1  68737292-68737392   c
            740-868             JAXUCZ010000011.1  68735441-68735569   c
            869-1034            JAXUCZ010000011.1  68734127-68734292   c
            1035-1160           JAXUCZ010000011.1  68731230-68731355   c
            1161-1322           JAXUCZ010000011.1  68729739-68729900   c
            1323-1422           JAXUCZ010000011.1  68727024-68727123   c
            1423-1566           JAXUCZ010000011.1  68725462-68725605   c
            1567-1741           JAXUCZ010000011.1  68724252-68724426   c
            1742-1823           JAXUCZ010000011.1  68722851-68722932   c
            1824-1990           JAXUCZ010000011.1  68721131-68721297   c
            1991-2116           JAXUCZ010000011.1  68719387-68719512   c
            2117-2214           JAXUCZ010000011.1  68710052-68710149   c
            2215-2334           JAXUCZ010000011.1  68707948-68708067   c
            2335-2530           JAXUCZ010000011.1  68705164-68705359   c
            2531-2716           JAXUCZ010000011.1  68702161-68702346   c
            2717-2866           JAXUCZ010000011.1  68700108-68700257   c
            2867-2918           JAXUCZ010000011.1  68698708-68698759   c
            2919-3067           JAXUCZ010000011.1  68697254-68697402   c
            3068-3193           JAXUCZ010000011.1  68693952-68694077   c
            3194-3292           JAXUCZ010000011.1  68692683-68692781   c
            3293-3475           JAXUCZ010000011.1  68689006-68689188   c
            3476-3607           JAXUCZ010000011.1  68682499-68682630   c
            3608-3793           JAXUCZ010000011.1  68682196-68682381   c
            3794-3920           JAXUCZ010000011.1  68680194-68680320   c
            3921-3973           JAXUCZ010000011.1  68676184-68676236   c
            3974-4173           JAXUCZ010000011.1  68674380-68674579   c
FEATURES             Location/Qualifiers
     source          1..4173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4173
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
     exon            1..253
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            254..384
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            385..638
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    476..478
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="upstream in-frame stop codon"
     CDS             491..4036
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="isoform 1 is encoded by transcript variant 3;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; solute carrier family 9, member 10; solute
                     carrier family 9, subfamily C (Na+-transporting carboxylic
                     acid decarboxylase), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 10 isoform 1"
                     /protein_id="NP_001424678.1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
                     /translation="MEEVFENLTTTHNVKLSNAWLDLLKSVFLSTPQDLPEIILILSL
                     ICTIGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFFGI
                     FTPVIIFNVAFDMDIYMLQKLFWQILLITIPGFMINYTLILWYLQSVNKLSLKTIPWL
                     LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKH
                     MNHTLAHKVMSTAWSYLVESFITGILITKAIQLWMATIFGDDVNHITLIFSVLYLIFY
                     VCELIGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPA
                     HTYLYISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKG
                     TPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIVNRFILPMAVIKLGLRDVT
                     STKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTE
                     HQKVKCPDCNKEIDETLNIEAMELANRRLLSAQIASYQRQYRNEILSQSAMQVLVGAA
                     GSFGEKKGEYMSPENIKNYSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHS
                     IVFTNEFEYTGYIAVLMNTYPMIICWISRLKDIYQYEIKCANYYFLTFYILEALLKVA
                     AMRKEFFSHTWLLFELGITLVGILDIILIETDSISYKFDLTETVVFMNVVRLLRILRI
                     LKLITPKLLQVIDKRMSQQISFRYAILKGYVQGEMDVLNIIDQIASSKQAKQILLKRV
                     IRNMDHAMKELGYLEYDHPEIAVTMKTKEEVNVMLNMAREIVKAFRSKGIIHKVEGAE
                     INKLIMAKKKQVLELQSVIQPLNVEEAPYYIPWLSEDPEAISFIQEKAKVVTFDCGNN
                     IFEEGDEPEGIYVIISGMVKLKRSKPHLEMDRVSSESEVAQTRSYTLPHTEYLLSGEI
                     IGELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKKYPNMKYKMWQKIGLAITAQ
                     KIRENLSFEDWNYKMQLKLCNVFVRDIPKTTKTDIYDETVTHVVLIHGSAEDCQLRKI
                     YKAPFLIPVTCHQIQGLEEFTKVMIIQTSVAVRKFRWNVKKYNPPRRISMKPDSTESL
                     ETLNESSEDDEDKKENEENEEYLEDIIDISSVSKK"
     misc_feature    599..2158
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    599..2158
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    3167..3550
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    3167..3550
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(3410..3415,3440..3448)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3410..3415,3440..3448)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3506..3514,3527..3535)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3506..3514,3527..3535)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            639..739
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            740..868
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1034
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1160
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1322
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1422
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1566
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1741
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1823
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1990
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2116
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2214
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2334
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2530
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2716
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2866
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2918
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3067
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3193
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3292
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3475
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3607
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3793
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3920
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..3973
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4173
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtcagt gaggttgcag ttggttttgg acagttctgg agtgagagga agttcctggc
       61 ctccacttct cacattctct aggacactcc tgtgccctgg atggtgagcc ctcctgttgt
      121 ttctctttct ggaagttgac ctttccatct ggtgcttgtt ctctggaccg cctctgttcg
      181 aagatcaaag gaagccactg tttagcttag agtcttggct cgcacttgtg ctttctcatt
      241 acaaccaaag actctttcca agtgattcat gctactgctg agatggagtc ttactggaca
      301 gacatagctg agagccgttg ctctatttcc agatcaacct caagctcttg ttttcttttg
      361 tgattttttt tttattattt tgagaagggc attaggaaga caccaagaag aaaagtccta
      421 ttccctttga tcccctgtga gtttttcaga gacacagagt ttgagacgct gactgtaatt
      481 aaatacggga atggaagaag tttttgagaa tctaactaca acccacaatg tcaaactgag
      541 taatgcatgg ctggatcttc tcaaaagcgt gtttttgagc actccccagg acctccctga
      601 aatcatcttg atactatctt tgatctgtac gattggagca tttttgaaca tgcatctgaa
      661 ggattttcca attcctcttc ctgtgatact atttttaatt ggatgctgtt ttgaaattct
      721 gagttttgca tctactcaga tccagttata tgcagatgcc atacagtgga tggatcctga
      781 catgtttttt gggatattta caccagtaat tatctttaat gttgcatttg acatggatat
      841 atacatgctt caaaagttat tttggcagat attattaatt acaattcctg gatttatgat
      901 taattacacc ttaatactgt ggtatctgca gtctgtgaat aaattatctt taaagaccat
      961 cccctggcta ctgttttcag ctgtgcttat cagttcagat cctatgctta cttcagcctc
     1021 cataagagac cttggtcttt ccagaagcct cacaaattta attaacggag agagtctact
     1081 gacctcagtg atatccttaa ttatatatag tgctgttgtg cagatcagtt tcaagtcaaa
     1141 gcatatgaac cataccctag cccataaggt catgtccaca gcttggtcat atcttgtgga
     1201 aagtttcatc actggaatcc taattacaaa agcgattcag ttatggatgg ctaccatctt
     1261 tggtgatgac gtcaaccaca tcacgctcat cttctcagtt ctatacctca tcttctatgt
     1321 ttgtgagcta attggaatgt ctggaatatt tactctggcc accataggac tttttctaaa
     1381 ttctacaagt tttaaaccag gagttgaagc atttctcctc gaattctgga actgcctgtc
     1441 ctttattggt ttccttatgg tgttcacttt cattggactt ctaatccctg cacacacata
     1501 tttatatata tcattttctg atgtgtatta ctcattaaat atctacttca cgctgattgt
     1561 tttaaggctt ctggtctttc tgctaatgag ccccattttg tctcgacttg gtcacgggtt
     1621 cagctggcgc tgggcgttca tcatggtctg gagtgaaatg aaaggaacac cgaacataaa
     1681 tatggccctt ctgcttgcct actcggacgt ttctcttggt tccgagaggg aaagatctca
     1741 aatattattc catggcgtgt cagtatgtgt aatcaccctg attgtcaata gatttatttt
     1801 gccaatggca gtaattaaac taggtcttcg tgatgtcaca tcaacaaaat ataaatcggt
     1861 ttattataca ttccagcact ttcaagagct aaccaaatcc acagccatgg cactcaaatt
     1921 tgacaaagat cttgctaacg ctgactggaa catggttgac aaggcgatta tacttcaaaa
     1981 tccatatgct ttaaaccaag aagaaacaac ggaacatcag aaggtgaaat gtcctgattg
     2041 caacaaggaa atagatgaga cccttaacat tgaagccatg gagttggcca acaggcgtct
     2101 cctgtcagcg caaatagcaa gctaccaacg acagtacagg aatgagattc tgtcccagag
     2161 tgcaatgcaa gtgttggtag gcgcggccgg aagctttggt gagaagaagg gagaatatat
     2221 gagtcctgag aacataaaga attattcaga aagcaaaaaa ctcctctcct ttcttagaaa
     2281 attactactc aactgggtat ataatactaa aaaagataaa ggggttccat caagatacat
     2341 gtttcttcat gcatgccata gcatagtctt cacaaatgaa tttgaataca ctggatacat
     2401 cgctgtatta atgaacacat atccgatgat aatctgttgg atttcccgac taaaagacat
     2461 ctatcaatat gagataaaat gtgctaacta ctattttctt acattttata ttctagaggc
     2521 tctacttaag gtggcagcaa tgaggaagga atttttttca cacacctggc tcctgtttga
     2581 gctcgggatt accttggtcg gcatcctaga tataatactt atcgaaacag actccattag
     2641 ttacaaattt gacttaactg agactgtggt cttcatgaac gtggttcgac tccttcgtat
     2701 actgcgcatc ttgaagctta taacaccaaa attgctgcaa gtaatagaca aaaggatgag
     2761 ccagcagata tccttccggt atgctatact aaaaggctac gtccaagggg aaatggatgt
     2821 actgaatata attgatcaga ttgcaagttc caaacaggct aaacagatat tgttaaagcg
     2881 agtaataagg aatatggatc atgctatgaa agagctgggc tacctagagt atgatcaccc
     2941 agaaatcgct gtcactatga aaaccaagga ggaggttaat gtgatgctca atatggccag
     3001 agaaattgtc aaggctttca ggtccaaagg aattatacat aaggtggaag gcgctgagat
     3061 caacaagtta atcatggcca aaaagaaaca agtgcttgag ctgcagtctg ttatccagcc
     3121 acttaatgtt gaagaagccc catactatat cccatggctc agtgaagatc ctgaagccat
     3181 aagctttatt caggaaaaag caaaagttgt gacatttgac tgcggaaata acatatttga
     3241 ggaaggcgac gaaccagaag gaatctatgt aataatttcg ggcatggtaa agcttaaaag
     3301 gtcaaagcca cacctggaga tggatagagt gtcctcagag tcagaggttg ctcagactag
     3361 aagttataca ctgcctcaca cagaatatct gctcagcggg gaaataatag gagagttaaa
     3421 ctgtttgact aaagaacgga tgcaatattc tgccacctgc aaaactgttg tggagacgta
     3481 ttttattccc attagccact tgtatgaagg ctttgaaaaa aaatacccta acatgaaata
     3541 taaaatgtgg caaaaaatcg gacttgccat tactgcccaa aagatccggg aaaacttatc
     3601 ttttgaggac tggaactaca agatgcagtt gaaactctgc aatgtcttcg taagggacat
     3661 acccaagacc acaaaaactg acatctatga tgaaacggta acccatgttg tcctcatcca
     3721 tggatctgca gaagactgcc agttgcgaaa aatttataag gcacctttcc taattcccgt
     3781 gacatgccat cagatacaag gcttagaaga gttcacaaaa gtcatgatta ttcaaacttc
     3841 cgttgctgtg agaaaattca ggtggaatgt aaaaaagtac aacccacctc gaaggatttc
     3901 aatgaaacca gattctacag aatcacttga aacattaaat gaaagttctg aagatgatga
     3961 ggataaaaaa gagaatgaag aaaatgagga atatttggaa gatattattg acatctcaag
     4021 tgtctccaag aaataacctg gaaagaaagt ttagtcagtc gcctgagctt ctcaccatgg
     4081 caatgaaaac atatatttat ggagatagag acaagccaaa gtttatatgc ctcttgtgtg
     4141 ataatgtgaa ttaaagtacc ttgcactagt caa
//
LOCUS       NM_001437698            4778 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 18,
            mRNA.
ACCESSION   NM_001437698 XM_063270238
VERSION     NM_001437698.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4778)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4778)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4778)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4778)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4778)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4778)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4778)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4778)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4778)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4778)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270238.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.612294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000011.1  98085846-98085923
            79-226              JAXUCZ010000011.1  98101064-98101211
            227-273             JAXUCZ010000011.1  98105694-98105740
            274-345             JAXUCZ010000011.1  98106090-98106161
            346-432             JAXUCZ010000011.1  98108322-98108408
            433-595             JAXUCZ010000011.1  98109928-98110090
            596-716             JAXUCZ010000011.1  98113029-98113149
            717-848             JAXUCZ010000011.1  98115531-98115662
            849-1055            JAXUCZ010000011.1  98117537-98117743
            1056-1176           JAXUCZ010000011.1  98123938-98124058
            1177-1332           JAXUCZ010000011.1  98124251-98124406
            1333-1422           JAXUCZ010000011.1  98124558-98124647
            1423-1515           JAXUCZ010000011.1  98126328-98126420
            1516-1572           JAXUCZ010000011.1  98128415-98128471
            1573-1605           JAXUCZ010000011.1  98129443-98129475
            1606-1800           JAXUCZ010000011.1  98131039-98131233
            1801-1910           JAXUCZ010000011.1  98131384-98131493
            1911-2070           JAXUCZ010000011.1  98133415-98133574
            2071-4778           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4778
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..78
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="upstream in-frame stop codon"
     exon            79..226
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..273
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..345
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..432
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2127
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 18 is encoded by transcript variant 18;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 18"
                     /protein_id="NP_001424627.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMAT
                     SEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLD
                     INNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRIN
                     VLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARIC
                     YIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLE
                     EPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV
                     HNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKLIQDNRRET
                     KNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQK
                     GHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNH
                     VKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHL
                     W"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    1834..2106
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1834..2106
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            433..595
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..716
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..848
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1055
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1176
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1332
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1515
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1572
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1605
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1800
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1910
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2070
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..4778
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgtcgc ttccttccgg cggctgaggt ccggacgggc tctggagttg cggtggacag
       61 aagggcagca agctagtgag cagtggaaag agctcagtgc tggaaagcct agtggggagg
      121 gaccttcttc ccagagggac tggtgtggtc acccggagac ctcttattct gcagctggtc
      181 cacgtttcac cagaagataa aagaaaaaca acaggagaag aaaatggagt tgaagcagaa
      241 gaatggggta aatttcttca caccaaaaac aagctttaca cagattttga tgaaattcga
      301 caagaaattg aaaatgaaac tgaaagaatt tcaggaaata ataagggagt aagccctgag
      361 ccaatccatc tcaaggtttt ctcgcccaac gttgtcaacc tgacgcttgt ggatttacca
      421 ggaatgacca aagtacctgt aggtgatcag cccaaggata ttgagcttca aatcagagaa
      481 cttattcttc ggttcatcag taatcccaat tccattatcc ttgctgtcac tgctgcaaat
      541 acagatatgg caacgtcaga ggcacttaag atttccagag aggtagatcc agatgggcgc
      601 agaactctag ctgtaatcac caagcttgat ctcatggatg cgggtactga tgccatggat
      661 gtattgatgg gaagggttat tccagtcaag cttggaataa ttggagtagt taacaggagc
      721 caactggaca ttaacaataa gaagagtgta actgattcaa tccgtgatga gtatgctttt
      781 cttcaaaaga agtacccatc tctggccaac agaaatggaa caaagtatct tgctaggact
      841 ctgaataggt tacttatgca tcatatcaga gactgtttac cagagctgaa aacaagaata
      901 aatgtcttag ctgctcagta tcagtctctt ctaaatagct atggtgagcc cgtggatgat
      961 aaaagtgcta ctttactcca gctcattacc aagtttgcca cagagtattg taacactatt
     1021 gaaggaacgg caaagtacat tgaaacttct gagctatgtg gtggtgctag gatttgttat
     1081 attttccatg agacttttgg gcgaacctta gaatctgttg atccactagg tggccttaac
     1141 actattgaca tcttgaccgc cattagaaat gctactggcc cccgtccagc tttatttgtg
     1201 cctgaagttt catttgagtt actggtcaaa cgtcagatta agcgtctaga ggagcccagc
     1261 ctccgctgtg tggagctggt ccacgaggaa atgcagagga tcattcagca ctgtagcaac
     1321 tacagcacac aggaactgtt acggttccct aaactccatg atgccatagt tgaagtagtg
     1381 acttgtcttc ttcgtaaaag gttgcccgtg acaaatgaaa tggtacataa cttagtggca
     1441 attgagctag catatatcaa cacaaaacac cccgactttg ctgatgcctg tgggctaatg
     1501 aacaataaca tagaggaaca aagaagaaac agactagcaa gagaactacc ttccgctgta
     1561 tcgcgagaca agttaattca ggacaacaga agagaaacta aaaatgttgc atctgcaggt
     1621 ggtggaattg gagatggtgg tcgaattgga gatggtggtc aggaaccgac aacaggcaac
     1681 tggagaggaa tgctgaaaac ttcaaaagct gaagaattac ttgctgaaga aaaatcaaaa
     1741 ccaattccaa ttatgccagc aagtccacaa aaaggccatg ctgtcaattt gctagatgtg
     1801 ccagttccag ttgcacgaaa actgtctgcc cgagaacagc gagattgtga ggttattgaa
     1861 agactcatca aatcatattt tctaattgtc agaaagaata ttcaagacag cgtcccaaag
     1921 gcagtaatgc attttttggt taatcatgtg aaagatactc ttcagagtga attagtaggg
     1981 cagctgtata agtcatcctt attagatgac cttctgactg aatccgagga catggcacag
     2041 cgaagaaaag aagcggctga catgctgaag gcattacaag gagccagtca aattattgct
     2101 gaaatccgag agactcatct ttggtgaaca gaactgtttg gtcttctaca ctttgctgac
     2161 ttgaacctac tagctactgc ctacctgagt agaaatttat ttatggactt ttgtgtatcg
     2221 cagtgtatga atttgcttgt gtgaagactg gctataagct gaaaagtata ttattcatta
     2281 caagacaaat cacatgttta attcacattt ttcaagtttc ctatgatgta tatcaagtct
     2341 gtccgtttca gtcaaactta caagaacaat tgatgttcta gttgtacaaa gcagtttgcc
     2401 tgtgcatatg atgacctgcg taaccttttt ttagtcttaa agctgcagcc gtagtcctca
     2461 aagaggaagc tccaggacat ttcatgacta taatgcatgc actatttata tagactgacc
     2521 tggcttcaaa aggtggagcc tggcgagttc ctcacataat caatgtatcc acctatcctt
     2581 catttttata gtcttaaaaa acaaacaaaa ttctgaaact tctgcagttt taggaaaaat
     2641 ataagatctg aaagactcat aaagatgtag gaacagactg tgtaattaat ggctcctgag
     2701 tctatactgc cctaatgtta gaaagtaaaa tatgctttga ttcaaaataa gcctgaaaat
     2761 ataaattgac ttcctgcatt aaaaataact attaggaact ttcttagtaa caataactgg
     2821 tcctgttagt ttctaaatga ctcagtgaca acctaaattt ccctaattta caagtacatc
     2881 gattgcagtc cagatgcacc ttagggtggg gcgctgactc tgggctccga gactcagtta
     2941 tgtgagacct aaaagtctac tctgtatcca ctggtaatgc tactttatag ttccacacca
     3001 acagaataca tttgtcaaag aaaaatacct ggacatacac atacacctaa aagcttatgg
     3061 actactaaac tgtattcagg ggttgaggat ttacaaccta ttttgtgaaa actgcctgtg
     3121 caattcaatt tctgacctag ctgggcagtg gtggtgcaca cctttaatcc cagcttttgg
     3181 gaggcagagg caggtggatc tctgagttca aggccagcct ggtctacaga gttgagttcc
     3241 aagacaacca gaactacaca gagaaaccct gtcttgaacc cccctccccc caaaaaattg
     3301 aaacctaaat agaaatcttt gatgtatcta gttttctctg accaaatgat acatttgtgt
     3361 tataaatact aaaattcttt tcaggtcagg catcttatga aatactatta gcaaggaaaa
     3421 caagaacatg ttatctttag tttagatgcc cattgaacca tctcaaaaac aaaggcagtc
     3481 tgataacagt accagcttga cagtgagtat acactgccta aatgtgttag catacttaag
     3541 aaaaatatcc tgttatctaa ctattaggta tccatggttt attttttaag agagatgacc
     3601 accactgtag ccttttgaat ttgtaaagag aaagaatgca cctttatcca acatttcaaa
     3661 tagattttaa aaggaagatg ttagctttaa aaacgtgcta tgataatgta cttgttagca
     3721 ctacacactt tgtacaaaga aaaacaagca agaaaggtag ggaaatgaaa gcttcctttg
     3781 tgtactttta cactaagctg tgttctgaaa catggagata atttataaga ccactgtatg
     3841 ttctatgtaa ataaaaatgc tggtgtgaaa tggcattacg gtttgccagt aagtgaattc
     3901 ttcctgactt gccgtaagag agaggtttaa ataggtgcat ctttgaaata tctgaatcta
     3961 cttcataatg gaacgattta aattgtactg caccaaaagt tttatgccat ttttttaatt
     4021 agataatcac caccaaggcc ttgttacatc tttgtgtcta cagatgaaga cagaaacttc
     4081 ttccaagtaa tccaaggatg aatgctgaga acatgaactt tgctgcaaga cgtctagaag
     4141 ctgatccaca gtttatgttt cacccctatg tacattgggg tggtgctatc ttgattttta
     4201 cagaaactgt ttttgagaat tagcttgcct tgtgtataca aacctgaact agtttgactt
     4261 caaaacttcc tgtatctttt ctgttcttac tgactgcata cttgatgaga tactttttgt
     4321 ttctttggtt tcttaaaata tctgctatag gaacccactg gcaaaaatag gcagttatca
     4381 gtaaattatt gaaacacaga acaaggaagt ggaaaactga actataaatg aagtctggta
     4441 ctgattgatg ttttgtttta agaaaaaact attttgtact acagtttcta ttgggaacca
     4501 ctgccatatc taactccttt ttaagaattc tgtttgcttg gcagcatcaa tcagaagttt
     4561 aactttgtaa cagatttctc acatctaaac agacattaga agcttggcca gtttgtacag
     4621 ctatgtaaca caactgcaat caggtgctta ccttacctcc tgtgttaact ttatacagtc
     4681 atttccactg caccacttct tcagaccaag gagcaagaaa gatcattctt gcataaagaa
     4741 atgaactata attaaatatc actttatttt gaaatgca
//
LOCUS       NM_001437766            1667 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 7, mRNA.
ACCESSION   NM_001437766 XM_039088353
VERSION     NM_001437766.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039088353.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2856034.1,
                                           SRR26360194.1883352.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000011.1  77465394-77465485   c
            93-162              JAXUCZ010000011.1  77464858-77464927   c
            163-274             JAXUCZ010000011.1  77462369-77462480   c
            275-437             JAXUCZ010000011.1  77461993-77462155   c
            438-567             JAXUCZ010000011.1  77456828-77456957   c
            568-661             JAXUCZ010000011.1  77452674-77452767   c
            662-761             JAXUCZ010000011.1  77449073-77449172   c
            762-940             JAXUCZ010000011.1  77444544-77444722   c
            941-1050            JAXUCZ010000011.1  77442290-77442399   c
            1051-1160           JAXUCZ010000011.1  77440692-77440801   c
            1161-1303           JAXUCZ010000011.1  77435682-77435824   c
            1304-1452           JAXUCZ010000011.1  77433449-77433597   c
            1453-1667           JAXUCZ010000011.1  77432471-77432685   c
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1667
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..92
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            93..162
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     exon            163..274
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1503
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 2 is encoded by transcript variant 7; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 2"
                     /protein_id="NP_001424695.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAASIKISSLGLERWLSG"
     misc_feature    1042..>1122
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1042..>1122
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    <1051..>1485
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1051..>1485
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1327..>1449
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <1327..>1449
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    1348..1404
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1348..1404
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            275..437
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            438..567
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            568..661
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..761
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            762..940
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1050
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1160
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1303
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1452
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1667
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag gtacgctgtg cgggtcgggc
       61 cctgaggtgg acgaacgcgg ggaaaagatg agtgattcct ggaagcagtg aagggcacgg
      121 ccttgggatt cttgattcct caaaggtcag cctagcaaca gggtggtaga aaaaatgaag
      181 ccagcgggta cagacccaag gatcttgtct ttagctgctg aagtagcgaa aagtcctgaa
      241 caaaatgtcc ctgttatatt attgaagtta aaagaaataa taaacaacac ccctttggga
      301 agctcagagt taaagaaagt caagcaagat atatattgtt atgacctcat tcaatactgt
      361 ctattggtcc tcagtcaaga ttcttctcga atccagggtg gttggtctac aatttcccag
      421 ctgacacaga tactaagcca ttgctgtgtg ggattagagc caggagaaga tggagaagaa
      481 ttttacaagg aattacttcc atcagctgcc gaaaattttc ttgtcctggg aagacgattg
      541 caaacatgtt ttatcaatgc aactaagggt gaagagcaag ataaattact acattttttc
      601 caaattgtga ctgattctct cttctggcta ttgggaggtc atattcaact catacagaat
      661 gtactgcaga gtgatcattt cttgcaccta ctgcaaactg acaatgttca aataggagct
      721 acagtcatga ctctgcttca gaatatacta cagatcaaca gtggtaattt actcaaaata
      781 gaaggaaaag ccctgcattc tattttagat gaaattcttt tcaagctttt gtcaactcct
      841 agtccagtca taagaagtac tgctacaaag ctcctactgg tattggctga atcccatcag
      901 gaaattttga ttttactgag actaagtgcc tgctataaag gacttagaag tctgctaaat
      961 aaacaggaaa ctcttacaga atttagtcga gaacttagac agctcgttga tcttttaacc
     1021 cctaagatcc aacaggaagt agaagaacag aaactacata aagcagcttg cttgattcaa
     1081 gcctattgga aaggtttcca gaccagaaaa agattaaaga agcttccgtc tgctgtgatt
     1141 gccttgcaga ggagtttcag agctaaacga acaaagatgt tgttggagct aaataggcag
     1201 aaggaagaag aagacctcag attaagattg caacttcaaa aacagagagc catgaggctt
     1261 tcccgagagt cacgcttgag tatgcttgaa ataattcatc caggtcaagt ggagaaatac
     1321 aatagggaaa tagaagagaa atctgcattg actatccaga aacattggag agggtacagg
     1381 gaaaggaaga attttcgcca acagaggcca tctctcacag agtataaagc agctgtcaca
     1441 cttcagagag cagcctctat taagatttca agtctggggc tggagagatg gctcagcggt
     1501 taagagcact gactgctctt ccagaggtcc tgagttcaat tcccagcaac cacgtggtgg
     1561 ctcacaacca tctgtaatgg gatctgatgc cctcttctgc tgtgtctgaa gacagctaca
     1621 atgtactctt atacatgaaa taaataaagt aaatctttaa aaaaaaa
//
LOCUS       NM_001024740            1923 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 116 (Ccdc116),
            transcript variant 3, mRNA.
ACCESSION   NM_001024740 XM_237828
VERSION     NM_001024740.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Wang,Y., Wu,W., Zhu,M., Wang,C., Shen,W., Cheng,Y., Geng,L., Li,Z.,
            Zhang,J., Dai,J., Ma,H., Chen,L., Hu,Z., Jin,G. and Shen,H.
  TITLE     Integrating expression-related SNPs into genome-wide gene- and
            pathway-based analyses identified novel lung cancer susceptibility
            genes
  JOURNAL   Int J Cancer 142 (8), 1602-1610 (2018)
   PUBMED   29193083
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced NM_001024740.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.70231.1,
                                           SRR26360181.2615745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000011.1  97349708-97349772
            66-203              JAXUCZ010000011.1  97350002-97350139
            204-752             JAXUCZ010000011.1  97351042-97351590
            753-1923            JAXUCZ010000011.1  97351695-97352865
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1923
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="coiled-coil domain containing 116"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
     exon            1..65
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..203
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    93..95
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="upstream in-frame stop codon"
     CDS             132..1754
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="isoform 2 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 116; stromal
                     cell-derived factor 2-like 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 116
                     isoform 2"
                     /protein_id="NP_001019911.1"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
                     /translation="MARCRHHSGYLADDEAAHGTYVARLPKKHLLPEMRPTCKLGRVP
                     HLPSMNRYSERQGHQQNLRRPRAFGGFLDFLTEGQVLDSLQTVVEQATECVATMKTEA
                     GVPLVDVQDRVEVPNSRHRSRGRPSINTVHRHRARPTLCAGHPNNYPSCSSSMSDSHS
                     SVTAGWLGSRSQDSDLGARGVGSLPPMRDKLLLEKNLKRLLRLESKGKVLNQHCSQRD
                     SLLWDSLGSQSSSQPTREQPLSWFSGLLASTSVTPETSELGLGEQEMIFLKQELNKEI
                     KSLLNQPTSFNLPTYCPLREPHRTLDFLSEHHLFPALQRVVSQAVDKLSHACRHNGFP
                     LFPVTSELSPVFPGNSDLQPSSKASLPTDREARGETCYSPTSASSPKTSHRKSKDRRG
                     SPSNAVQMATRFRLKVTPTEVSNVPIPSSQCMLKSPNSDLKLQKQTTASNHNHIPQPR
                     HGLHLTLPAPGITVEVASCQGQLRGQVQHSLATPCHLHSHFPFPVFSPFLPLGKSFST
                     SPPTLCPEVSSRAGLEVLEGHLKGRGCFTHHF"
     misc_feature    183..1361
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    183..1361
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    1170..1331
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1308..1310
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V8B5.1); phosphorylation site"
     exon            204..752
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1923
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgcggt agagctttaa agggtgctga atgagtgaac ccctagaagc acagcagaga
       61 ctctgaggag tctgcatctg tgctgtagga cctgaagaag gaagcagaaa acaaatttaa
      121 ttatccacat catggcaagg tgccgccacc actcaggtta tctggctgac gacgaggctg
      181 ctcacggcac ctatgtggct cggctgccca agaagcatct gttgccagag atgaggccaa
      241 cttgcaagct tgggcgtgta ccacacctac catcaatgaa ccgatactca gagcgccagg
      301 gccaccagca aaaccttagg cgccctcggg catttggtgg cttcctggat ttcctcacgg
      361 agggtcaggt actggacagc ttgcagacag tcgtggagca ggcaacagaa tgtgtggcta
      421 ccatgaagac agaggctgga gtgccactgg tggatgtaca agaccgagtg gaggtgccaa
      481 atagtaggca tcgttctcga ggcagaccca gcatcaacac tgtgcatcgg caccgtgctc
      541 ggcccacgct gtgtgctgga cacccaaaca attacccatc ttgctccagc tccatgtctg
      601 actcccatag cagcgtcaca gctggatggc tggggtcccg cagccaagac agtgacctgg
      661 gtgccagagg cgtaggctca ttgccaccca tgagggacaa actcctgctt gagaaaaacc
      721 tcaagaggct gctacgactg gaaagcaaag ggaaagttct gaatcaacac tgctcccaga
      781 gggattccct gctatgggac tcactgggca gccagagcag cagtcagccg acccgggaac
      841 agcccctgtc ttggttctct gggcttctgg cctccacttc agtcacccct gaaacttcag
      901 agttgggact cggagaacaa gagatgattt tcctcaaaca agaattaaac aaggagataa
      961 agtcactgct gaaccagcca acctccttca acctgcctac ctattgtcca ctcagggaac
     1021 cccatcgtac cctggatttc ctgtctgagc accacctctt tccagccctg cagcgtgtgg
     1081 tcagccaggc tgtagacaag ctgagccatg cctgccgcca caatggcttc cccctcttcc
     1141 ctgttacctc agagctgtct ccagtgtttc ctgggaactc cgatcttcaa cccagctcta
     1201 aggcttcctt acccaccgac agggaggcta ggggagagac ttgttattct cccacctcgg
     1261 cctccagccc taagacatct cacagaaaaa gcaaggacag aaggggctcc ccatctaatg
     1321 cagtccagat ggctaccaga ttcaggctca aggtgacacc tacagaagtc tctaatgtcc
     1381 ctatcccctc atcccagtgc atgctgaagt ctcctaactc tgacctcaaa ttgcagaaac
     1441 aaactacagc ctcaaaccac aaccatatac ctcagccccg ccatggcctg cacctcaccc
     1501 tgcctgcccc tgggatcaca gtggaggtgg cctcctgcca gggccaactc aggggccagg
     1561 tccagcatag tcttgccact ccctgccatc tccactccca tttccctttc cctgtgttct
     1621 ccccattcct tcccctggga aaaagctttt ccacttcccc tcctacactg tgtcctgagg
     1681 tgtcctccag agcagggctg gaggtcttgg agggacattt gaagggaagg ggctgcttca
     1741 cccatcactt ctagtagcca ctgttactgg caaggtgccc aaggacaaga tctcttgccc
     1801 tgcactgtgg aactcctccg aggtagatat aagctgcctg gggatcaggt gtcctagtcc
     1861 atctatttcc agtgtccaga tgttgtcaaa gattaataaa ggctattttt taccctgctt
     1921 ttt
//
LOCUS       NM_001437768            1620 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 6, mRNA.
ACCESSION   NM_001437768 XM_063270526
VERSION     NM_001437768.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1475429.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000011.1  77465446-77465485   c
            41-110              JAXUCZ010000011.1  77464858-77464927   c
            111-227             JAXUCZ010000011.1  77462369-77462485   c
            228-390             JAXUCZ010000011.1  77461993-77462155   c
            391-520             JAXUCZ010000011.1  77456828-77456957   c
            521-614             JAXUCZ010000011.1  77452674-77452767   c
            615-714             JAXUCZ010000011.1  77449073-77449172   c
            715-893             JAXUCZ010000011.1  77444544-77444722   c
            894-1003            JAXUCZ010000011.1  77442290-77442399   c
            1004-1113           JAXUCZ010000011.1  77440692-77440801   c
            1114-1256           JAXUCZ010000011.1  77435682-77435824   c
            1257-1405           JAXUCZ010000011.1  77433449-77433597   c
            1406-1620           JAXUCZ010000011.1  77432471-77432685   c
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1620
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..40
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            41..110
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            111..227
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     CDS             128..1456
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 2 is encoded by transcript variant 6; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 2"
                     /protein_id="NP_001424697.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAASIKISSLGLERWLSG"
     misc_feature    995..>1075
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    995..>1075
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    <1004..>1438
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1004..>1438
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1280..>1402
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <1280..>1402
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    1301..1357
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1301..1357
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            228..390
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            391..520
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..614
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            615..714
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            715..893
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1003
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1113
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1256
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1405
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1620
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag tgattcctgg aagcagtgaa
       61 gggcacggcc ttgggattct tgattcctca aaggtcagcc tagcaacagg cataggtggt
      121 agaaaaaatg aagccagcgg gtacagaccc aaggatcttg tctttagctg ctgaagtagc
      181 gaaaagtcct gaacaaaatg tccctgttat attattgaag ttaaaagaaa taataaacaa
      241 cacccctttg ggaagctcag agttaaagaa agtcaagcaa gatatatatt gttatgacct
      301 cattcaatac tgtctattgg tcctcagtca agattcttct cgaatccagg gtggttggtc
      361 tacaatttcc cagctgacac agatactaag ccattgctgt gtgggattag agccaggaga
      421 agatggagaa gaattttaca aggaattact tccatcagct gccgaaaatt ttcttgtcct
      481 gggaagacga ttgcaaacat gttttatcaa tgcaactaag ggtgaagagc aagataaatt
      541 actacatttt ttccaaattg tgactgattc tctcttctgg ctattgggag gtcatattca
      601 actcatacag aatgtactgc agagtgatca tttcttgcac ctactgcaaa ctgacaatgt
      661 tcaaatagga gctacagtca tgactctgct tcagaatata ctacagatca acagtggtaa
      721 tttactcaaa atagaaggaa aagccctgca ttctatttta gatgaaattc ttttcaagct
      781 tttgtcaact cctagtccag tcataagaag tactgctaca aagctcctac tggtattggc
      841 tgaatcccat caggaaattt tgattttact gagactaagt gcctgctata aaggacttag
      901 aagtctgcta aataaacagg aaactcttac agaatttagt cgagaactta gacagctcgt
      961 tgatctttta acccctaaga tccaacagga agtagaagaa cagaaactac ataaagcagc
     1021 ttgcttgatt caagcctatt ggaaaggttt ccagaccaga aaaagattaa agaagcttcc
     1081 gtctgctgtg attgccttgc agaggagttt cagagctaaa cgaacaaaga tgttgttgga
     1141 gctaaatagg cagaaggaag aagaagacct cagattaaga ttgcaacttc aaaaacagag
     1201 agccatgagg ctttcccgag agtcacgctt gagtatgctt gaaataattc atccaggtca
     1261 agtggagaaa tacaataggg aaatagaaga gaaatctgca ttgactatcc agaaacattg
     1321 gagagggtac agggaaagga agaattttcg ccaacagagg ccatctctca cagagtataa
     1381 agcagctgtc acacttcaga gagcagcctc tattaagatt tcaagtctgg ggctggagag
     1441 atggctcagc ggttaagagc actgactgct cttccagagg tcctgagttc aattcccagc
     1501 aaccacgtgg tggctcacaa ccatctgtaa tgggatctga tgccctcttc tgctgtgtct
     1561 gaagacagct acaatgtact cttatacatg aaataaataa agtaaatctt taaaaaaaaa
//
LOCUS       NM_001437756            4409 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 3, mRNA.
ACCESSION   NM_001437756 XM_039088307
VERSION     NM_001437756.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4409)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4409)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4409)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4409)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4409)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4409)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039088307.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.29827.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               JAXUCZ010000011.1  81641872-81642274   c
            404-584             JAXUCZ010000011.1  81639358-81639538   c
            585-655             JAXUCZ010000011.1  81637098-81637168   c
            656-826             JAXUCZ010000011.1  81634588-81634758   c
            827-979             JAXUCZ010000011.1  81633460-81633612   c
            980-1257            JAXUCZ010000011.1  81632731-81633008   c
            1258-1384           JAXUCZ010000011.1  81632129-81632255   c
            1385-1531           JAXUCZ010000011.1  81631579-81631725   c
            1532-1626           JAXUCZ010000011.1  81631398-81631492   c
            1627-1821           JAXUCZ010000011.1  81627329-81627523   c
            1822-1913           JAXUCZ010000011.1  81625109-81625200   c
            1914-2024           JAXUCZ010000011.1  81624334-81624444   c
            2025-3373           JAXUCZ010000011.1  81622398-81623746   c
            3374-3469           JAXUCZ010000011.1  81622212-81622307   c
            3470-3597           JAXUCZ010000011.1  81621930-81622057   c
            3598-4409           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4409
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..403
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    287..289
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             326..3604
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 3"
                     /protein_id="NP_001424685.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEW
                     DAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKM
                     VTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA
                     TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVT
                     LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT
                     FVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV
                     GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDP
                     PDLLSVELSTSRPTQHLGRMKREPPPRPPQPAIFTHSKWGCSGCLGPRPLSPLSPLLE
                     EPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKAGRSSGGEVTLID
                     FGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLP
                     PPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGETNYAFVPEQAQLPPALEDNLF
                     LPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIP
                     PRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQGSRTPSPLVPPGSSPLP
                     HRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLL
                     PERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPK
                     ANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAARPADKVQMLQAMVHGVTTEECQ
                     AALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLLGSCGPA
                     HHKR"
     misc_feature    437..622
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    437..622
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    758..1531
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    758..1531
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(764..772,788..790,836..838,842..844,983..994,
                     1004..1006,1124..1126,1136..1141,1145..1147,1178..1180,
                     1235..1249,1274..1276,1376..1378)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(764..772,788..790,836..838,842..844,983..994,
                     1004..1006,1124..1126,1136..1141,1145..1147,1178..1180,
                     1235..1249,1274..1276,1376..1378)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(764..772,788..790,836..838,842..844,983..994,
                     1004..1006,1124..1126,1136..1141,1145..1147,1178..1180)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(764..772,788..790,836..838,842..844,983..994,
                     1004..1006,1124..1126,1136..1141,1145..1147,1178..1180)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1124..1126,1136..1138,1235..1249,1274..1276,
                     1376..1378)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1124..1126,1136..1138,1235..1249,1274..1276,
                     1376..1378)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1175..1207,1211..1255)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1175..1207,1211..1255)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1553..1702
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1553..1702
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1559..1561,1565..1567,1580..1582,1634..1636,
                     1640..1642,1685..1687,1691..1696)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(1559..1561,1565..1567,1580..1582,1634..1636,
                     1640..1642,1685..1687,1691..1696)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    1715..1912
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1715..1912
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <2219..3319
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2219..3319
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2825..3001
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2825..3001
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3362..3493
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3362..3493
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3452..3571
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3452..3571
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            404..584
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..655
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..826
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..979
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1257
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1384
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1531
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1626
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1821
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1913
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2024
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..3373
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3469
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3597
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..4409
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcaggcaa gcaggcggtg gggggaagct ggggagtagg accagagctg tgagcactgc
       61 actggagaca ggacagagga cccagcctgt gaccagctgt ggaaacccag ccaggcttgc
      121 aggggagcca agccaccact ccattcttct tccctgtttc ctacttctgt gtgggatctg
      181 agggatttct aggacctgtt ccccctactc tctgggcaga ccatagaact cagaagctgg
      241 ggcccttgcc tgcccacttt agaacgaggc catagctcct gtgacttagg ggcttcagct
      301 tgtggagggg cttcagcttg tggagatgcc agcagcccgt cgatttcctg gccttgagct
      361 ctccttccct ctcctggcca gactgcggcg acgactgtat acaaggctgg ggagcagcag
      421 catgcagccg gaggagggaa caggctggct gctggagctg ctgtctgagg tgcagctaca
      481 acagtatttc ctgaggctcc gagatgacct caacattacc cgcctgtctc attttgagta
      541 tgtcaaaaac gaagacctgg aaaagattgg catgggccgg cctggccaga ggcggctatg
      601 ggaggctgtg aagaggagga aggccatgtg caaacgcaag tcatggatga gcaagagcac
      661 cttccggaag ccctccccca ccccaggggg cctggcaggg gaggggaccc tgcagagcct
      721 cacctgcctc attggggaga aagacctgcg cctgctggag aagctgggag atggctcctt
      781 tggcgtggtg cgcaggggtg aatgggatgc ccctgcaggg aagacggtga gtgtggccgt
      841 gaagtgcctg aaacctgatg tgctgagcca gcccgaggcc atggacgact tcatccggga
      901 ggtcaatgcc atgcattcgc tagaccaccg aaacctcatt cgcttgtacg gtgtggtgct
      961 cacaccaccc atgaagatgg tgacagagct ggcccctctg ggatccttgt tggaccggct
     1021 acgtaaacac caaggtcatt tcctcttggg gacgctgagt cgctatgccg tgcaggtggc
     1081 tgagggcatg ggctacctgg agtccaagcg cttcattcac cgagacctgg ctgctcgaaa
     1141 tctgcttttg gccacccgtg acctggtcaa gattggggac tttggactga tgcgagctct
     1201 gccccagaat gatgaccact atgtcatgca agaacatcgc aaggtgccct ttgcctggtg
     1261 tgcccctgag agcctgaaga cacggacttt ctcccatgcc agtgacacct ggatgtttgg
     1321 ggtcacactg tgggagatgt ttacgtatgg ccaggagccc tggattggcc tcaatggcag
     1381 ccagatcctg cataagattg acaaggaagg ggagcgcctg ccccggcctg aggactgccc
     1441 ccaagacatc tacaatgtca tggtccagtg ctgggcccac aagccagagg acagacccac
     1501 atttgtggcc cttcgggact tcctgctgga ggctcagcct acagacatgc gggcccttca
     1561 ggacttcgag gagccggaca agctgcacat ccagatgaac gacgtcatta ctgtcattga
     1621 gggaagggct gagaactact ggtggcgtgg tcagaacaca cggacgctgt gtgtgggacc
     1681 cttccctcga aatgtggtga cctctgtggc tggcctgtca gcccaggaca tcagccagcc
     1741 tctacagaat agcttcattc acacagggca tggcgacagt gacccccgcc actgctgggg
     1801 gttccctgac aggatcgatg aactgtacct gggaaacccc atggaccccc ctgacctgct
     1861 gagtgtggaa ctgagcacct cgcgacccac ccagcattta ggacggatga aaagggagcc
     1921 tccacctcgc ccacctcagc ctgccatctt cactcacagt aagtggggct gttcaggatg
     1981 ccttggcccc cgccctctct ctcctctctc tcctctcctg gaagagccaa catatgaccc
     2041 tgtgagtgag gacccagacc ccctgtccag cgacttcaag agacttggcc tgaggaagcc
     2101 agccctgccc cgagggctct ggctggcaaa gccctcagcc cgggtgccag gcaccaaggc
     2161 aggccgcagc agtgggggtg aggtcacact catcgacttc ggcgaggagc ctgtagcccc
     2221 aaccccacgg ccctgtgcac cttccttggc acagttggcc atggatgcct gctccctgct
     2281 ggacaagaca ccaccacaga gccccacacg ggcactgcca cgacctttac atcctacacc
     2341 tgtggtggac tgggacgctc gcccgctgcc cccgccccct gcctacgatg atgtggccca
     2401 agatgaggat gacttcgagg tgtgctctat caacagcacc ctagtgagtg caggcctccc
     2461 taccgggcct agccaaggcg agaccaatta tgcgtttgta cctgagcagg cccagctgcc
     2521 ccctgccctg gaggataacc tgttcctgcc accgcagggt ggaggccagc cacccagctc
     2581 agcccagact gcagagattt tccaggcact gcagcaggag tgtatgcggc agctacaggt
     2641 ccccactggc cagctgaccc cgtcccctac cccaggaggt gatgacaagc cccaggtgcc
     2701 accccgggta cctattcccc ctcggcccac acgtccacgt gtgggactat ctccagctcc
     2761 cttaggtgag gaagaggcaa gtcggtggcc tggaccctcc tcccctcccc gagtgcctcc
     2821 ccgggaaccc ctgtctcctc aagggtcgag gaccccaagc cccctagtac cacctggcag
     2881 ctccccacta ccgcatcggc tctcgagctc acctggaaag accatgccca ccacccagag
     2941 ctttgcctca gaccctaagt acgccactcc acaagtgatc caggctcctg gcccacgggc
     3001 tggcccctgc atcctgccca ttgtccgtga tggcaggaag gtcagcagca cccactatta
     3061 cctgctgcca gagcgccctc cctacctcga gcgctaccag cgcttcctga gggaggccca
     3121 gagccccgag gagccggccg ccctgcccgt tcccccactg ctgcccccgc ctagcactcc
     3181 agcccctgcc gcccccactg ccaccgtccg acctatgcct caggctgccc cagacccaaa
     3241 ggccaacttc tccaccaata acagcaaccc aggggcgcag ccaccatccc tgagggccag
     3301 tgcacggctg ccgcagaggg gctgcccagg ggatgggcaa gaggctgccc ggccagcaga
     3361 caaagtccag atgctgcagg ccatggtgca tggggtgacc acagaggagt gccaggcggc
     3421 cctgaggagc cacagctgga gtattcagag ggctgcccag tatctgaagg tggagcagct
     3481 ctttgggctg ggtcttcggc cacgggtgga gtgccacaaa gtgctagaga tgttcgactg
     3541 gaacctagag caagccggct gtcaccttct ggggtcctgt ggccctgccc accacaaacg
     3601 ctgatggttg actggagagc aatggtctgc cctaagagaa cctcttgaac ctgtctgtgg
     3661 gacaagggtg gggagatgcc ctgcctcagg cctggaggac ccacaactgc ctgcggctcc
     3721 cagtggacag tgagacccag gcagcaggag gctgggagcc tcaccttgcc cacctcgctc
     3781 acccacccag cgctgttctg cacaccttgg ttcagccctc agtgccccaa ccaagaggtg
     3841 ggaagttcca agccttgtga aggcaagaca ggaagctgcc tggcaggccc tgtgtgtgac
     3901 ctgcctttgg ccccagacca aggctgggct ggtggctaga gtgtgcccca ggctttccct
     3961 gggggattag actgagagga agccaggctt gacttggaca agaaggatgt gttggccaca
     4021 cagaagggtg ggccagcacc caacaggccc tcctcaggac caggcccctt tccagggaac
     4081 ccctgtagga atgtggagtg ttggacagaa tgtgacctgt ggcttcactg tgaactcggg
     4141 cttggctggt cttagatctt gtagctgtaa acagcctgaa gtggctcaga aacagaagag
     4201 gcgccaggat cttctctggc agggaccagg gccccaggcc ccgggtgtgg agggagaccc
     4261 cagcggcacc agtacttgtc ctgtttgatg cctgttcctc ccctgtgtcc atttgatgtg
     4321 ttcccatcgc ctctgttgcc aaagctgctg tcccagccat ggatatctgc ttcttccaga
     4381 gaaataaagt ctgtttctat tttacgtca
//
LOCUS       NM_001437757            4348 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 4, mRNA.
ACCESSION   NM_001437757 XM_017597984
VERSION     NM_001437757.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4348)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4348)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4348)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4348)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4348)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4348)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4348)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4348)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4348)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4348)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_017597984.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.45967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  81641872-81642273   c
            403-583             JAXUCZ010000011.1  81639358-81639538   c
            584-654             JAXUCZ010000011.1  81637098-81637168   c
            655-876             JAXUCZ010000011.1  81634588-81634809   c
            877-1029            JAXUCZ010000011.1  81633460-81633612   c
            1030-1307           JAXUCZ010000011.1  81632731-81633008   c
            1308-1434           JAXUCZ010000011.1  81632129-81632255   c
            1435-1581           JAXUCZ010000011.1  81631579-81631725   c
            1582-1676           JAXUCZ010000011.1  81631398-81631492   c
            1677-1871           JAXUCZ010000011.1  81627329-81627523   c
            1872-1963           JAXUCZ010000011.1  81625109-81625200   c
            1964-3312           JAXUCZ010000011.1  81622398-81623746   c
            3313-3408           JAXUCZ010000011.1  81622212-81622307   c
            3409-3536           JAXUCZ010000011.1  81621930-81622057   c
            3537-4348           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4348
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             325..3543
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 4"
                     /protein_id="NP_001424686.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRL
                     LEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH
                     RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLE
                     SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL
                     KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
                     YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEG
                     RAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCW
                     GFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRMKKPTYDPVSEDPDPLSSDFKR
                     LGLRKPALPRGLWLAKPSARVPGTKAGRSSGGEVTLIDFGEEPVAPTPRPCAPSLAQL
                     AMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSI
                     NSTLVSAGLPTGPSQGETNYAFVPEQAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQ
                     ALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEA
                     SRWPGPSSPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASD
                     PKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSP
                     EEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRAS
                     ARLPQRGCPGDGQEAARPADKVQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVE
                     QLFGLGLRPRVECHKVLEMFDWNLEQAGCHLLGSCGPAHHKR"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212754"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <2158..3258
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2158..3258
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2764..2940
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2764..2940
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3301..3432
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3301..3432
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3391..3510
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3391..3510
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            403..583
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..654
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..876
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1029
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1307
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1434
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1581
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1676
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1871
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1963
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..3312
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3408
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3536
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..4348
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcaag caggcggtgg ggggaagctg gggagtagga ccagagctgt gagcactgca
       61 ctggagacag gacagaggac ccagcctgtg accagctgtg gaaacccagc caggcttgca
      121 ggggagccaa gccaccactc cattcttctt ccctgtttcc tacttctgtg tgggatctga
      181 gggatttcta ggacctgttc cccctactct ctgggcagac catagaactc agaagctggg
      241 gcccttgcct gcccacttta gaacgaggcc atagctcctg tgacttaggg gcttcagctt
      301 gtggaggggc ttcagcttgt ggagatgcca gcagcccgtc gatttcctgg ccttgagctc
      361 tccttccctc tcctggccag actgcggcga cgactgtata caaggctggg gagcagcagc
      421 atgcagccgg aggagggaac aggctggctg ctggagctgc tgtctgaggt gcagctacaa
      481 cagtatttcc tgaggctccg agatgacctc aacattaccc gcctgtctca ttttgagtat
      541 gtcaaaaacg aagacctgga aaagattggc atgggccggc ctggccagag gcggctatgg
      601 gaggctgtga agaggaggaa ggccatgtgc aaacgcaagt catggatgag caaggtgttc
      661 agtggaaagc ggcaggaggc tgagttccct tcccatcact ctcagagcac cttccggaag
      721 ccctccccca ccccaggggg cctggcaggg gaggggaccc tgcagagcct cacctgcctc
      781 attggggaga aagacctgcg cctgctggag aagctgggag atggctcctt tggcgtggtg
      841 cgcaggggtg aatgggatgc ccctgcaggg aagacggtga gtgtggccgt gaagtgcctg
      901 aaacctgatg tgctgagcca gcccgaggcc atggacgact tcatccggga ggtcaatgcc
      961 atgcattcgc tagaccaccg aaacctcatt cgcttgtacg gtgtggtgct cacaccaccc
     1021 atgaagatgg tgacagagct ggcccctctg ggatccttgt tggaccggct acgtaaacac
     1081 caaggtcatt tcctcttggg gacgctgagt cgctatgccg tgcaggtggc tgagggcatg
     1141 ggctacctgg agtccaagcg cttcattcac cgagacctgg ctgctcgaaa tctgcttttg
     1201 gccacccgtg acctggtcaa gattggggac tttggactga tgcgagctct gccccagaat
     1261 gatgaccact atgtcatgca agaacatcgc aaggtgccct ttgcctggtg tgcccctgag
     1321 agcctgaaga cacggacttt ctcccatgcc agtgacacct ggatgtttgg ggtcacactg
     1381 tgggagatgt ttacgtatgg ccaggagccc tggattggcc tcaatggcag ccagatcctg
     1441 cataagattg acaaggaagg ggagcgcctg ccccggcctg aggactgccc ccaagacatc
     1501 tacaatgtca tggtccagtg ctgggcccac aagccagagg acagacccac atttgtggcc
     1561 cttcgggact tcctgctgga ggctcagcct acagacatgc gggcccttca ggacttcgag
     1621 gagccggaca agctgcacat ccagatgaac gacgtcatta ctgtcattga gggaagggct
     1681 gagaactact ggtggcgtgg tcagaacaca cggacgctgt gtgtgggacc cttccctcga
     1741 aatgtggtga cctctgtggc tggcctgtca gcccaggaca tcagccagcc tctacagaat
     1801 agcttcattc acacagggca tggcgacagt gacccccgcc actgctgggg gttccctgac
     1861 aggatcgatg aactgtacct gggaaacccc atggaccccc ctgacctgct gagtgtggaa
     1921 ctgagcacct cgcgacccac ccagcattta ggacggatga aaaagccaac atatgaccct
     1981 gtgagtgagg acccagaccc cctgtccagc gacttcaaga gacttggcct gaggaagcca
     2041 gccctgcccc gagggctctg gctggcaaag ccctcagccc gggtgccagg caccaaggca
     2101 ggccgcagca gtgggggtga ggtcacactc atcgacttcg gcgaggagcc tgtagcccca
     2161 accccacggc cctgtgcacc ttccttggca cagttggcca tggatgcctg ctccctgctg
     2221 gacaagacac caccacagag ccccacacgg gcactgccac gacctttaca tcctacacct
     2281 gtggtggact gggacgctcg cccgctgccc ccgccccctg cctacgatga tgtggcccaa
     2341 gatgaggatg acttcgaggt gtgctctatc aacagcaccc tagtgagtgc aggcctccct
     2401 accgggccta gccaaggcga gaccaattat gcgtttgtac ctgagcaggc ccagctgccc
     2461 cctgccctgg aggataacct gttcctgcca ccgcagggtg gaggccagcc acccagctca
     2521 gcccagactg cagagatttt ccaggcactg cagcaggagt gtatgcggca gctacaggtc
     2581 cccactggcc agctgacccc gtcccctacc ccaggaggtg atgacaagcc ccaggtgcca
     2641 ccccgggtac ctattccccc tcggcccaca cgtccacgtg tgggactatc tccagctccc
     2701 ttaggtgagg aagaggcaag tcggtggcct ggaccctcct cccctccccg agtgcctccc
     2761 cgggaacccc tgtctcctca agggtcgagg accccaagcc ccctagtacc acctggcagc
     2821 tccccactac cgcatcggct ctcgagctca cctggaaaga ccatgcccac cacccagagc
     2881 tttgcctcag accctaagta cgccactcca caagtgatcc aggctcctgg cccacgggct
     2941 ggcccctgca tcctgcccat tgtccgtgat ggcaggaagg tcagcagcac ccactattac
     3001 ctgctgccag agcgccctcc ctacctcgag cgctaccagc gcttcctgag ggaggcccag
     3061 agccccgagg agccggccgc cctgcccgtt cccccactgc tgcccccgcc tagcactcca
     3121 gcccctgccg cccccactgc caccgtccga cctatgcctc aggctgcccc agacccaaag
     3181 gccaacttct ccaccaataa cagcaaccca ggggcgcagc caccatccct gagggccagt
     3241 gcacggctgc cgcagagggg ctgcccaggg gatgggcaag aggctgcccg gccagcagac
     3301 aaagtccaga tgctgcaggc catggtgcat ggggtgacca cagaggagtg ccaggcggcc
     3361 ctgaggagcc acagctggag tattcagagg gctgcccagt atctgaaggt ggagcagctc
     3421 tttgggctgg gtcttcggcc acgggtggag tgccacaaag tgctagagat gttcgactgg
     3481 aacctagagc aagccggctg tcaccttctg gggtcctgtg gccctgccca ccacaaacgc
     3541 tgatggttga ctggagagca atggtctgcc ctaagagaac ctcttgaacc tgtctgtggg
     3601 acaagggtgg ggagatgccc tgcctcaggc ctggaggacc cacaactgcc tgcggctccc
     3661 agtggacagt gagacccagg cagcaggagg ctgggagcct caccttgccc acctcgctca
     3721 cccacccagc gctgttctgc acaccttggt tcagccctca gtgccccaac caagaggtgg
     3781 gaagttccaa gccttgtgaa ggcaagacag gaagctgcct ggcaggccct gtgtgtgacc
     3841 tgcctttggc cccagaccaa ggctgggctg gtggctagag tgtgccccag gctttccctg
     3901 ggggattaga ctgagaggaa gccaggcttg acttggacaa gaaggatgtg ttggccacac
     3961 agaagggtgg gccagcaccc aacaggccct cctcaggacc aggccccttt ccagggaacc
     4021 cctgtaggaa tgtggagtgt tggacagaat gtgacctgtg gcttcactgt gaactcgggc
     4081 ttggctggtc ttagatcttg tagctgtaaa cagcctgaag tggctcagaa acagaagagg
     4141 cgccaggatc ttctctggca gggaccaggg ccccaggccc cgggtgtgga gggagacccc
     4201 agcggcacca gtacttgtcc tgtttgatgc ctgttcctcc cctgtgtcca tttgatgtgt
     4261 tcccatcgcc tctgttgcca aagctgctgt cccagccatg gatatctgct tcttccagag
     4321 aaataaagtc tgtttctatt ttacgtca
//
LOCUS       NM_001437697            4823 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus dynamin 1-like (Dnm1l), transcript variant 17,
            mRNA.
ACCESSION   NM_001437697 XM_063270237
VERSION     NM_001437697.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4823)
  AUTHORS   Chen,T., Yang,J., Zheng,Y., Zhou,X., Huang,H., Zhang,H. and Xu,Z.
  TITLE     ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated
            Mitochondrial Dynamic
  JOURNAL   Synapse 78 (5), e22309 (2024)
   PUBMED   39285628
  REMARK    GeneRIF: ERK1/2 Regulates Epileptic Seizures by Modulating the
            DRP1-Mediated Mitochondrial Dynamic.
REFERENCE   2  (bases 1 to 4823)
  AUTHORS   Sun,J., Shao,Y., Pei,L., Zhu,Q., Yu,X. and Yao,W.
  TITLE     AKAP1 alleviates VSMC phenotypic modulation and neointima formation
            by inhibiting Drp1-dependent mitochondrial fission
  JOURNAL   Biomed Pharmacother 176, 116858 (2024)
   PUBMED   38850669
  REMARK    GeneRIF: AKAP1 alleviates VSMC phenotypic modulation and neointima
            formation by inhibiting Drp1-dependent mitochondrial fission.
REFERENCE   3  (bases 1 to 4823)
  AUTHORS   Zhang,H., Chen,L., Li,J., Sun,J., Zhao,Q., Wang,S. and Li,G.
  TITLE     STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related
            protein 1) controlled-mitochondrial fission during the development
            of apoptotic-resistance in pulmonary arterial endothelial cells
  JOURNAL   Genes Genomics 46 (7), 751-762 (2024)
   PUBMED   38733520
  REMARK    GeneRIF: STAT3 phosphorylation at Tyr705 affects DRP1
            (dynamin-related protein 1) controlled-mitochondrial fission during
            the development of apoptotic-resistance in pulmonary arterial
            endothelial cells.
REFERENCE   4  (bases 1 to 4823)
  AUTHORS   Dubois,M., Boulghobra,D., Rochebloine,G., Pallot,F., Yehya,M.,
            Bornard,I., Gayrard,S., Coste,F., Walther,G., Meyer,G.,
            Gaillard,J.C., Armengaud,J., Alpha-Bazin,B. and Reboul,C.
  TITLE     Hyperglycemia triggers RyR2-dependent alterations of mitochondrial
            calcium homeostasis in response to cardiac ischemia-reperfusion:
            Key role of DRP1 activation
  JOURNAL   Redox Biol 70, 103044 (2024)
   PUBMED   38266577
  REMARK    GeneRIF: Hyperglycemia triggers RyR2-dependent alterations of
            mitochondrial calcium homeostasis in response to cardiac
            ischemia-reperfusion: Key role of DRP1 activation.
REFERENCE   5  (bases 1 to 4823)
  AUTHORS   Fan,R.Z., Sportelli,C., Lai,Y., Salehe,S.S., Pinnell,J.R.,
            Brown,H.J., Richardson,J.R., Luo,S. and Tieu,K.
  TITLE     A partial Drp1 knockout improves autophagy flux independent of
            mitochondrial function
  JOURNAL   Mol Neurodegener 19 (1), 26 (2024)
   PUBMED   38504290
  REMARK    GeneRIF: A partial Drp1 knockout improves autophagy flux
            independent of mitochondrial function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4823)
  AUTHORS   Smirnova,E., Griparic,L., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Dynamin-related protein Drp1 is required for mitochondrial division
            in mammalian cells
  JOURNAL   Mol Biol Cell 12 (8), 2245-2256 (2001)
   PUBMED   11514614
REFERENCE   7  (bases 1 to 4823)
  AUTHORS   Chen,C.H., Hwang,S.L., Howng,S.L., Chou,C.K. and Hong,Y.R.
  TITLE     Three rat brain alternative splicing dynamin-like protein variants:
            interaction with the glycogen synthase kinase 3beta and action as a
            substrate
  JOURNAL   Biochem Biophys Res Commun 268 (3), 893-898 (2000)
   PUBMED   10679301
REFERENCE   8  (bases 1 to 4823)
  AUTHORS   Pitts,K.R., Yoon,Y., Krueger,E.W. and McNiven,M.A.
  TITLE     The dynamin-like protein DLP1 is essential for normal distribution
            and morphology of the endoplasmic reticulum and mitochondria in
            mammalian cells
  JOURNAL   Mol Biol Cell 10 (12), 4403-4417 (1999)
   PUBMED   10588666
REFERENCE   9  (bases 1 to 4823)
  AUTHORS   Imoto,M., Tachibana,I. and Urrutia,R.
  TITLE     Identification and functional characterization of a novel human
            protein highly related to the yeast dynamin-like GTPase Vps1p
  JOURNAL   J Cell Sci 111 (Pt 10), 1341-1349 (1998)
   PUBMED   9570752
REFERENCE   10 (bases 1 to 4823)
  AUTHORS   Yoon,Y., Pitts,K.R., Dahan,S. and McNiven,M.A.
  TITLE     A novel dynamin-like protein associates with cytoplasmic vesicles
            and tubules of the endoplasmic reticulum in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 779-793 (1998)
   PUBMED   9472031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063270237.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.691021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000011.1  98085846-98085923
            79-226              JAXUCZ010000011.1  98101064-98101211
            227-273             JAXUCZ010000011.1  98105694-98105740
            274-345             JAXUCZ010000011.1  98106090-98106161
            346-432             JAXUCZ010000011.1  98108322-98108408
            433-595             JAXUCZ010000011.1  98109928-98110090
            596-716             JAXUCZ010000011.1  98113029-98113149
            717-848             JAXUCZ010000011.1  98115531-98115662
            849-1055            JAXUCZ010000011.1  98117537-98117743
            1056-1176           JAXUCZ010000011.1  98123938-98124058
            1177-1332           JAXUCZ010000011.1  98124251-98124406
            1333-1422           JAXUCZ010000011.1  98124558-98124647
            1423-1515           JAXUCZ010000011.1  98126328-98126420
            1516-1572           JAXUCZ010000011.1  98128415-98128471
            1573-1650           JAXUCZ010000011.1  98129086-98129163
            1651-1845           JAXUCZ010000011.1  98131039-98131233
            1846-1955           JAXUCZ010000011.1  98131384-98131493
            1956-2115           JAXUCZ010000011.1  98133415-98133574
            2116-4823           JAXUCZ010000011.1  98133859-98136566
FEATURES             Location/Qualifiers
     source          1..4823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4823
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
     exon            1..78
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="upstream in-frame stop codon"
     exon            79..226
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..273
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..345
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..432
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2172
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /EC_number="3.6.5.5"
                     /note="isoform 17 is encoded by transcript variant 17;
                     dynamin-1-like protein; N-terminal region; dynamin-like
                     protein 1; C-terminal region; dynamin-related protein 1"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform 17"
                     /protein_id="NP_001424626.1"
                     /db_xref="GeneID:114114"
                     /db_xref="RGD:620416"
                     /translation="MTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMAT
                     SEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLD
                     INNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRIN
                     VLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARIC
                     YIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLE
                     EPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV
                     HNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALA
                     PASQEPSPAASAEADGKVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAE
                     EKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNI
                     QDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKAL
                     QGASQIIAEIRETHLW"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <424..741
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    649..1506
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin central region; Region: Dynamin_M;
                     pfam01031"
                     /db_xref="CDD:460033"
     misc_feature    1879..2151
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     misc_feature    1879..2151
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /note="Dynamin GTPase effector domain; Region: GED;
                     pfam02212"
                     /db_xref="CDD:460495"
     exon            433..595
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..716
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..848
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1055
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1176
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1332
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1515
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1572
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1650
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1845
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1955
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2115
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..4823
                     /gene="Dnm1l"
                     /gene_synonym="DLP1; Dnml1; Drp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgtcgc ttccttccgg cggctgaggt ccggacgggc tctggagttg cggtggacag
       61 aagggcagca agctagtgag cagtggaaag agctcagtgc tggaaagcct agtggggagg
      121 gaccttcttc ccagagggac tggtgtggtc acccggagac ctcttattct gcagctggtc
      181 cacgtttcac cagaagataa aagaaaaaca acaggagaag aaaatggagt tgaagcagaa
      241 gaatggggta aatttcttca caccaaaaac aagctttaca cagattttga tgaaattcga
      301 caagaaattg aaaatgaaac tgaaagaatt tcaggaaata ataagggagt aagccctgag
      361 ccaatccatc tcaaggtttt ctcgcccaac gttgtcaacc tgacgcttgt ggatttacca
      421 ggaatgacca aagtacctgt aggtgatcag cccaaggata ttgagcttca aatcagagaa
      481 cttattcttc ggttcatcag taatcccaat tccattatcc ttgctgtcac tgctgcaaat
      541 acagatatgg caacgtcaga ggcacttaag atttccagag aggtagatcc agatgggcgc
      601 agaactctag ctgtaatcac caagcttgat ctcatggatg cgggtactga tgccatggat
      661 gtattgatgg gaagggttat tccagtcaag cttggaataa ttggagtagt taacaggagc
      721 caactggaca ttaacaataa gaagagtgta actgattcaa tccgtgatga gtatgctttt
      781 cttcaaaaga agtacccatc tctggccaac agaaatggaa caaagtatct tgctaggact
      841 ctgaataggt tacttatgca tcatatcaga gactgtttac cagagctgaa aacaagaata
      901 aatgtcttag ctgctcagta tcagtctctt ctaaatagct atggtgagcc cgtggatgat
      961 aaaagtgcta ctttactcca gctcattacc aagtttgcca cagagtattg taacactatt
     1021 gaaggaacgg caaagtacat tgaaacttct gagctatgtg gtggtgctag gatttgttat
     1081 attttccatg agacttttgg gcgaacctta gaatctgttg atccactagg tggccttaac
     1141 actattgaca tcttgaccgc cattagaaat gctactggcc cccgtccagc tttatttgtg
     1201 cctgaagttt catttgagtt actggtcaaa cgtcagatta agcgtctaga ggagcccagc
     1261 ctccgctgtg tggagctggt ccacgaggaa atgcagagga tcattcagca ctgtagcaac
     1321 tacagcacac aggaactgtt acggttccct aaactccatg atgccatagt tgaagtagtg
     1381 acttgtcttc ttcgtaaaag gttgcccgtg acaaatgaaa tggtacataa cttagtggca
     1441 attgagctag catatatcaa cacaaaacac cccgactttg ctgatgcctg tgggctaatg
     1501 aacaataaca tagaggaaca aagaagaaac agactagcaa gagaactacc ttccgctgta
     1561 tcgcgagaca agtcttctaa agttccaagt gctttggcac ctgcctccca ggagccctcc
     1621 cctgccgctt ctgccgaggc tgatggcaag gttgcatctg caggtggtgg aattggagat
     1681 ggtggtcgaa ttggagatgg tggtcaggaa ccgacaacag gcaactggag aggaatgctg
     1741 aaaacttcaa aagctgaaga attacttgct gaagaaaaat caaaaccaat tccaattatg
     1801 ccagcaagtc cacaaaaagg ccatgctgtc aatttgctag atgtgccagt tccagttgca
     1861 cgaaaactgt ctgcccgaga acagcgagat tgtgaggtta ttgaaagact catcaaatca
     1921 tattttctaa ttgtcagaaa gaatattcaa gacagcgtcc caaaggcagt aatgcatttt
     1981 ttggttaatc atgtgaaaga tactcttcag agtgaattag tagggcagct gtataagtca
     2041 tccttattag atgaccttct gactgaatcc gaggacatgg cacagcgaag aaaagaagcg
     2101 gctgacatgc tgaaggcatt acaaggagcc agtcaaatta ttgctgaaat ccgagagact
     2161 catctttggt gaacagaact gtttggtctt ctacactttg ctgacttgaa cctactagct
     2221 actgcctacc tgagtagaaa tttatttatg gacttttgtg tatcgcagtg tatgaatttg
     2281 cttgtgtgaa gactggctat aagctgaaaa gtatattatt cattacaaga caaatcacat
     2341 gtttaattca catttttcaa gtttcctatg atgtatatca agtctgtccg tttcagtcaa
     2401 acttacaaga acaattgatg ttctagttgt acaaagcagt ttgcctgtgc atatgatgac
     2461 ctgcgtaacc tttttttagt cttaaagctg cagccgtagt cctcaaagag gaagctccag
     2521 gacatttcat gactataatg catgcactat ttatatagac tgacctggct tcaaaaggtg
     2581 gagcctggcg agttcctcac ataatcaatg tatccaccta tccttcattt ttatagtctt
     2641 aaaaaacaaa caaaattctg aaacttctgc agttttagga aaaatataag atctgaaaga
     2701 ctcataaaga tgtaggaaca gactgtgtaa ttaatggctc ctgagtctat actgccctaa
     2761 tgttagaaag taaaatatgc tttgattcaa aataagcctg aaaatataaa ttgacttcct
     2821 gcattaaaaa taactattag gaactttctt agtaacaata actggtcctg ttagtttcta
     2881 aatgactcag tgacaaccta aatttcccta atttacaagt acatcgattg cagtccagat
     2941 gcaccttagg gtggggcgct gactctgggc tccgagactc agttatgtga gacctaaaag
     3001 tctactctgt atccactggt aatgctactt tatagttcca caccaacaga atacatttgt
     3061 caaagaaaaa tacctggaca tacacataca cctaaaagct tatggactac taaactgtat
     3121 tcaggggttg aggatttaca acctattttg tgaaaactgc ctgtgcaatt caatttctga
     3181 cctagctggg cagtggtggt gcacaccttt aatcccagct tttgggaggc agaggcaggt
     3241 ggatctctga gttcaaggcc agcctggtct acagagttga gttccaagac aaccagaact
     3301 acacagagaa accctgtctt gaacccccct ccccccaaaa aattgaaacc taaatagaaa
     3361 tctttgatgt atctagtttt ctctgaccaa atgatacatt tgtgttataa atactaaaat
     3421 tcttttcagg tcaggcatct tatgaaatac tattagcaag gaaaacaaga acatgttatc
     3481 tttagtttag atgcccattg aaccatctca aaaacaaagg cagtctgata acagtaccag
     3541 cttgacagtg agtatacact gcctaaatgt gttagcatac ttaagaaaaa tatcctgtta
     3601 tctaactatt aggtatccat ggtttatttt ttaagagaga tgaccaccac tgtagccttt
     3661 tgaatttgta aagagaaaga atgcaccttt atccaacatt tcaaatagat tttaaaagga
     3721 agatgttagc tttaaaaacg tgctatgata atgtacttgt tagcactaca cactttgtac
     3781 aaagaaaaac aagcaagaaa ggtagggaaa tgaaagcttc ctttgtgtac ttttacacta
     3841 agctgtgttc tgaaacatgg agataattta taagaccact gtatgttcta tgtaaataaa
     3901 aatgctggtg tgaaatggca ttacggtttg ccagtaagtg aattcttcct gacttgccgt
     3961 aagagagagg tttaaatagg tgcatctttg aaatatctga atctacttca taatggaacg
     4021 atttaaattg tactgcacca aaagttttat gccatttttt taattagata atcaccacca
     4081 aggccttgtt acatctttgt gtctacagat gaagacagaa acttcttcca agtaatccaa
     4141 ggatgaatgc tgagaacatg aactttgctg caagacgtct agaagctgat ccacagttta
     4201 tgtttcaccc ctatgtacat tggggtggtg ctatcttgat ttttacagaa actgtttttg
     4261 agaattagct tgccttgtgt atacaaacct gaactagttt gacttcaaaa cttcctgtat
     4321 cttttctgtt cttactgact gcatacttga tgagatactt tttgtttctt tggtttctta
     4381 aaatatctgc tataggaacc cactggcaaa aataggcagt tatcagtaaa ttattgaaac
     4441 acagaacaag gaagtggaaa actgaactat aaatgaagtc tggtactgat tgatgttttg
     4501 ttttaagaaa aaactatttt gtactacagt ttctattggg aaccactgcc atatctaact
     4561 cctttttaag aattctgttt gcttggcagc atcaatcaga agtttaactt tgtaacagat
     4621 ttctcacatc taaacagaca ttagaagctt ggccagtttg tacagctatg taacacaact
     4681 gcaatcaggt gcttacctta cctcctgtgt taactttata cagtcatttc cactgcacca
     4741 cttcttcaga ccaaggagca agaaagatca ttcttgcata aagaaatgaa ctataattaa
     4801 atatcacttt attttgaaat gca
//
LOCUS       NM_001437709            3248 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 7, mRNA.
ACCESSION   NM_001437709 XM_039087932
VERSION     NM_001437709.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3248)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3248)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3248)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3248)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039087932.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.204224.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000011.1  48251027-48251279   c
            254-471             JAXUCZ010000011.1  48198562-48198779   c
            472-623             JAXUCZ010000011.1  48179141-48179292   c
            624-827             JAXUCZ010000011.1  48168955-48169158   c
            828-908             JAXUCZ010000011.1  48168156-48168236   c
            909-980             JAXUCZ010000011.1  48166329-48166400   c
            981-1049            JAXUCZ010000011.1  48158807-48158875   c
            1050-1106           JAXUCZ010000011.1  48158140-48158196   c
            1107-1154           JAXUCZ010000011.1  48157502-48157549   c
            1155-3248           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3248
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..253
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    239..241
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     exon            254..471
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1675
                     /gene="Erg"
                     /note="isoform 7 is encoded by transcript variant 7; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 7"
                     /protein_id="NP_001424638.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVN
                     GSRNSPDECSVTKGGKMVGSPDTVGMSYGSYMEEKHMPPPNMTTNERRVIVPADPTLW
                     STDHVRQWLEWAVKEYGLLDVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHL
                     HYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDL
                     PYEPPRRSTWTGHSHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGS
                     GQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLS
                     RALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTH
                     PQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY"
     misc_feature    578..829
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    578..829
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1163..1414
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1163..1414
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            472..623
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            624..827
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            828..908
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            909..980
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1049
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1106
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1154
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..3248
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtttcta aattcactgt tgagcgccat ggattacttt tgtgaaggct ttttggagca
       61 cttctgaagt ttcagcttct ttacctgttc ctagcggtgt ctggatgtgg gtttgataca
      121 aggcaataat cacagaggtt ggagggcagg gtcaaagaga tggtcttgtc aatggtgaac
      181 tttggatgtg cttcggggac tcctcaccac caggcgcgcc agaaggtccc catggaagtg
      241 aggagatact cgggaggcct tgtcagttgt gagcgaggac cagtcactat ttgagtgtgc
      301 ctacggaacg ccacacctgg ctaagacaga aatgaccgca tcctcttcca gtgactatgg
      361 ccagacatcc aagatgagtc ccagagtccc acaacaggac tggctgtctc agcccccagc
      421 cagggtcacc atcaagatgg agtgcaaccc tagccaggtg aacggttcca ggaactcacc
      481 tgacgaatgc agtgtgacca aaggtgggaa gatggtgggc agccctgata ctgtgggaat
      541 gagctacggc agctacatgg aggagaagca catgccgccc cccaatatga ccacgaatga
      601 acgcagagtg atcgtccctg cagatcctac tctgtggagc acagaccatg tccggcagtg
      661 gctggagtgg gcagtgaaag aatacggcct cctagacgtg gacgtcttat tatttcagaa
      721 tattgacggg aaggagctgt gcaagatgac aaaagatgac ttccagaggc tcactccgag
      781 ctacaatgcc gacattcttc tctcacatct ccactacctc agagagactc cccttccaca
      841 tctgacatcc gacgacgttg ataaggcttt acaaaactct ccacggttaa tgcatgctag
      901 aaacacaggg ggtgcagctt ttattttccc caatacttca gtatatcccg aagccacgca
      961 gagaattaca actaggccag atttacctta tgagcctccc aggagatcaa cctggaccgg
     1021 ccacagccac cccacccctc agtccaaagc tgcccagcca tctccctcca cagtgcccaa
     1081 aactgaagac cagcgtcctc agttagatcc ttaccagatc ctgggaccca ccagtagtcg
     1141 ccttgctaat ccaggtagtg gccagatcca gctgtggcag ttcctgctag aactcctgtc
     1201 tgacagctcc aactccaact gcatcacctg ggaaggcacc aacggggagt tcaagatgac
     1261 agacccggat gaggtggctc ggcgctgggg ggagcggaag agcaagccca acatgaacta
     1321 tgacaaactc agccgtgccc tccgctacta ctacgacaaa aacatcatga ccaaggtgca
     1381 tgggaagcgc tatgcctaca agtttgactt ccacgggatt gcccaggccc tgcagcccca
     1441 tccccccgag tcgtccctgt acaagtaccc ctccgacctg ccgtacatgg gctcctatca
     1501 cacccacccc cagaagatga actttgtggc tccccaccct ccggccctcc cagtcacatc
     1561 ttccagtttc tttgctaccc cgaacccata ctggaattcg ccgactgggg gcatctaccc
     1621 gaacactagg ctcccagcca gccatatgcc ctctcacctg ggcacctact actagagacc
     1681 agatagaggc ctttcccaac agtgcacaat cgcctagcaa tcaccacaaa ctcagagaac
     1741 acaaatcgaa agtgcctcct gaggaatgga aacggttggc cagagctggg gaaggaagcc
     1801 ggggaaagaa aaccaaagac tcacagggga gggtgggcac cacccaagta ttactacaga
     1861 aatagaagaa gctcaaaata tactgtacat ggacatataa cctgtggtcc acccttgtca
     1921 aagacattgt atgtagaaaa gcgtgaccga gaagaacaac tgtccaagga agtggcctta
     1981 agtagtgtac aaactgtaga gtgtgggacc ttgcttgtac caggattcag tgagagcaat
     2041 agaaccataa cagtcttggc ctagcacacc atcacgtgtg atgacatttg aagggaaact
     2101 acctgtgttt aaaaacagaa aaaaacatat ccaaaccaaa taagaagagg aaaaaaaaaa
     2161 aaagatggcg gcccctccac agaccacaat ggctgtggat tttcttggct ggcatttgct
     2221 gttttcattg aaatcaggtt cgttccattt gatagggagc tgccagctct gtcaaactgt
     2281 gaagatgacc cagcgtctca tcaccttttc agtattacgg gaaatgtggg ccatgtggtg
     2341 ggcggggaat gtatgtgcat gttgttgtga gtatgtgatc atagaagaaa gactgaaacg
     2401 gaggaagaga tagaggatca ggggttgggg agggagttaa gggagaggag gaagtggaag
     2461 aggaagagga ggagggagga ggagaaaggg ggaggaagaa aaggaggaag aggagaaagg
     2521 aggaggaaga aaaggagaaa atgaggaaga gaaggaaaag aagaaaagaa gggggaggaa
     2581 gaggagaagg aggaagagga agagaggaag agaagcaagc tgctcaagcc accacagctg
     2641 aatttaggac atcttgggac caaagagcat gagtcaagat gtttgatgct gccagggttg
     2701 taagaaagga cacagatttg tggaggactg ggagcagtag tattcagaac caaaaatatg
     2761 tctctttgtg aaaaggaaat cataactgga attgtctgat atttaaaaaa ttcaggacct
     2821 cagtattcaa tggaggcttt gtccttcaca gggggcagtt gagaggtgac cttggtggct
     2881 accatggtca gagaccacac aggcattgtg ggtaggtggg ctccagtttt ccttaatgag
     2941 tcgcgaacgc tgtgcgttcg tcagaacgaa gtctacaagt caatggtttt tttcttttta
     3001 tataataatt atataactta tgcatttata cactacgagt tgacctcggc cagccaaaga
     3061 caccacacac acacacacac acacacacac acacacacac acacacacaa aagagacaat
     3121 caaacatatg atgtggcctt gaattttaac tctgtaatgc ttaatgttta caatatgaag
     3181 ttactagttc ttagaatgca gaatgtatgt taataaaaat gagcttggcc tctcatggcg
     3241 aaccagaa
//
LOCUS       NM_001012164            3046 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor E5 (Adgre5),
            mRNA.
ACCESSION   NM_001012164 XM_341662
VERSION     NM_001012164.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3046)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   2  (bases 1 to 3046)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 3046)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 3046)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3046)
  AUTHORS   Griffiths,M.R., Neal,J.W., Fontaine,M., Das,T. and Gasque,P.
  TITLE     Complement factor H, a marker of self protects against experimental
            autoimmune encephalomyelitis
  JOURNAL   J Immunol 182 (7), 4368-4377 (2009)
   PUBMED   19299737
REFERENCE   6  (bases 1 to 3046)
  AUTHORS   Aust,G., Steinert,M., Schutz,A., Boltze,C., Wahlbuhl,M., Hamann,J.
            and Wobus,M.
  TITLE     CD97, but not its closely related EGF-TM7 family member EMR2, is
            expressed on gastric, pancreatic, and esophageal carcinomas
  JOURNAL   Am J Clin Pathol 118 (5), 699-707 (2002)
   PUBMED   12428789
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083857.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341662.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132304, SAMD00132308
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..3046
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="adhesion G protein-coupled receptor E5"
                     /db_xref="GeneID:361383"
                     /db_xref="RGD:1305595"
     exon            1..57
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2504
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="CD97 antigen; CD97 molecule"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E5
                     precursor"
                     /protein_id="NP_001012164.1"
                     /db_xref="GeneID:361383"
                     /db_xref="RGD:1305595"
                     /translation="MRGVSCHLLLVLCFVPNLSGVGTQKASGCARWCPPNSECESNRS
                     CKCKPGFNSSSPDGLITNPAQSCEDINECIQTDNLCGPYAMCMNSEGSYYCVCNLGYK
                     LLSGAESFTNKSENTCQVSVLFPASVDTGMIPVPSSIHTVPTARKLPEQPTTVHPRTQ
                     LGDSGERTPKDVNECTSGQNQCHQSTHCINKMGGYSCICRRGWKPAPGSPNGPVNTVC
                     EDVDECSSGQHQCHSSAICKNIPGSYKCRCPPGWIAIPRDKPNNTVCQEPHFPTWTLL
                     PTAHSQALLSFSVEVQNLLRDFNPATVNYTIQKLIEAVDKLLEMPMDIGTQTQQVATQ
                     LLSNLEQSLRTLAQFLPKGPFTYKSPSNTELALMVKEQDNKDVTTVHHSQAWMQLDWA
                     VTAGAKSSENGYSVAGILSSPNIQKLLANTSLNLEQKRDTLEDLYGSPVQSVTLTFLS
                     NINAIFLTNTDTEKLASDVTFKFNLTSVKSLKAREELMCAYWKSHDNGSGSWATDGCS
                     MNDTGFCHCNHLTSFAVLMAQYHVQDPRLELITKVGLLLSLVCLLLCILTFLLVKPIQ
                     SSRTMVHLHLCICLFLGSVIFLVGVENEGGEVGLRCRLVAMLLHFCFLAAFCWMALEG
                     VELYFLVVRVFQGQGLSTWHRCLVGYGVPLLIVAISAAARMDGYGHATYCWLDFRKQG
                     FLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSEINPNMKKLRKARVLTITAIAQLLVL
                     GCTWGFGLFLFNPHSTWLSYIFTLLNCLQGLFLYVTLCLLNKKVREEYWKWACMVTGN
                     KYTEFTSSTTGTGTSQTRTLRPSESGM"
     sig_peptide     27..86
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    231..>329
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF-like domain; Region: EGF_CA;
                     smart00179"
                     /db_xref="CDD:214542"
     misc_feature    231..>329
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF-like domain; Region: EGF_CA;
                     smart00179"
                     /db_xref="CDD:214542"
     misc_feature    order(231..233,240..242,288..290)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(231..233,240..242,288..290)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    537..632
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    537..632
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    order(537..539,546..548,594..596)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(537..539,546..548,594..596)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    684..779
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    684..779
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:429571"
     misc_feature    order(684..686,693..695,741..743)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    order(684..686,693..695,741..743)
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:238011"
     misc_feature    1488..1604
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="GPCR proteolysis site, GPS, motif; Region: GPS;
                     pfam01825"
                     /db_xref="CDD:460350"
     misc_feature    1488..1604
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="GPCR proteolysis site, GPS, motif; Region: GPS;
                     pfam01825"
                     /db_xref="CDD:460350"
     misc_feature    1626..2417
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    1626..2417
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; Region: 7tm_GPCRs; cl28897"
                     /db_xref="CDD:475119"
     misc_feature    1635..1709
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320554"
     misc_feature    1635..1709
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320554"
     misc_feature    1734..1799
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320554"
     misc_feature    1734..1799
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320554"
     misc_feature    1833..1901
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320554"
     misc_feature    1833..1901
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320554"
     misc_feature    1956..2006
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320554"
     misc_feature    1956..2006
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320554"
     misc_feature    2064..2135
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320554"
     misc_feature    2064..2135
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320554"
     misc_feature    2214..2282
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320554"
     misc_feature    2214..2282
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320554"
     misc_feature    2292..2369
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320554"
     misc_feature    2292..2369
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320554"
     exon            58..108
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            109..231
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            232..384
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            385..537
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            538..684
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            685..825
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            826..872
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            873..950
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1116
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1233
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1457
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1625
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1817
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2044
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2114
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2206
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2375
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2474
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..3019
                     /gene="Adgre5"
                     /gene_synonym="Cd97"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagacgctg tccgttccgc gccaccatga ggggcgtcag ctgtcacctc ctgctcgtgt
       61 tatgctttgt accgaatctc tcaggagttg gaacccaaaa ggcatcgggc tgtgccaggt
      121 ggtgccctcc caactcagaa tgtgagagta acagaagctg taagtgcaag ccaggcttca
      181 actcctcctc gcccgacggt ttgatcacta accctgcaca gagctgtgaa gacatcaacg
      241 agtgtataca aaccgataat ctctgtggac cgtatgccat gtgtatgaac tcagagggga
      301 gctactactg cgtctgcaac ctgggataca agctcctttc tggggcggaa tcttttacta
      361 ataagagtga gaacacgtgt caagtctctg tcctcttccc agcatccgtg gacactggga
      421 tgatacctgt gccctccagc atccacacag ttcctactgc cagaaagctc ccggagcagc
      481 caactacagt gcacccacgg acacagctgg gagactcagg ggaaaggacc cccaaggatg
      541 tgaatgaatg cacctctggg caaaaccagt gccaccagtc cacgcactgc atcaacaaga
      601 tgggcggcta ttcctgcatc tgtcgccgag gctggaaacc tgctcctgga tcccccaatg
      661 gcccagtcaa cacagtgtgt gaagatgtgg atgagtgcag ttctggccaa catcaatgcc
      721 acagttccgc catctgcaaa aatatccctg gctcctacaa gtgccgctgc cctccaggtt
      781 ggatagcaat tcctcgtgat aagccaaata acaccgtatg ccaagaacca catttcccta
      841 cctggacgct gctgcccaca gcccacagcc aggctctgtt gagtttctct gttgaagtcc
      901 agaatctgct cagagacttc aatccagcca cggtcaacta caccatccag aaactcatcg
      961 aggctgtgga caaactgctg gaaatgccca tggatatagg gactcaaacc caacaagttg
     1021 ccacccagtt gctctcgaac ctggagcaaa gccttcggac cttggcccag ttcttaccca
     1081 aaggcccttt cacctacaag tccccttcaa acactgaact ggccctgatg gtcaaggagc
     1141 aagacaacaa agatgttacc acagtgcacc acagccaagc ttggatgcag ctggactggg
     1201 ctgtgacagc tggagccaaa agctcagaaa atggctactc agtggcgggc atcctgtcca
     1261 gtccaaacat acaaaagctg ctggccaaca cctccttgaa cctggagcag aagagggaca
     1321 ccttggaaga cctctatgga agcccggttc agagcgtcac acttacgttc ctctcgaaca
     1381 tcaacgccat ctttctgacc aacacagaca ctgagaagct cgcctcagat gtcacgttca
     1441 agttcaacct aacttctgtg aagtcactta aggcacgtga agaactgatg tgtgcctact
     1501 ggaaaagcca tgacaatggg agtgggtcct gggccactga cggctgctca atgaatgaca
     1561 ctggcttctg ccactgcaac cacctgacca gctttgctgt cctaatggct cagtaccacg
     1621 tgcaggaccc aaggctggaa ctgatcacca aggtggggtt gctgctgtcc ctggtctgcc
     1681 tgctgctctg tatcctgacc ttcctgctgg tgaagcccat ccagagttct cgaaccatgg
     1741 tgcacctgca cctgtgcatc tgccttttcc tgggctcagt catcttcctg gttggtgttg
     1801 agaatgaagg gggcgaggtg ggtctgcgct gccgcctggt ggctatgctg ctgcatttct
     1861 gcttcctggc cgccttctgc tggatggccc tggagggtgt ggagctctac ttcctggtgg
     1921 tgcgtgtgtt ccagggccaa ggcctgagca cgtggcaccg ctgtctggtt ggctatgggg
     1981 tgcccctcct catcgtggcc atctcggcag ctgccagaat ggacggctat gggcatgcga
     2041 cctactgctg gttggacttc aggaagcagg gctttctctg gagcttttcg ggccctgtgg
     2101 ccttcatcat tttctgcaat gctgccattt ttgtgatcac tgtctggaag ctcaccaaga
     2161 agttttctga aatcaaccca aacatgaaga aattaaggaa ggcgagagtg ctgaccatca
     2221 cagccattgc ccagctcctc gtgctgggct gcacctgggg cttcggcctg ttcctcttca
     2281 accctcatag cacatggctg tcctacatct ttaccctgct caactgcctg cagggccttt
     2341 tcctctatgt gacgctctgc ctgctcaaca aaaaggtgag ggaagagtac tggaaatggg
     2401 cctgcatggt caccgggaac aagtacacag agttcacctc ttccacaaca ggcactggca
     2461 ccagtcaaac acggaccctc aggccctcag aatcggggat gtgaaggcaa gttccatgta
     2521 ggacagcagc acatattcaa ggccgccatt ttgccttctg ttcccgccac cctcccgcct
     2581 ttggccccac ttcagataaa ggaagggatg taaacccagc agtgagccct gcaagagggc
     2641 aaggggccac agctcctgct tctggttgcc tctctgcctc accgtgacag ctattgccta
     2701 ccagagaaac aaagccagac agcccagacc tgcagcccac tgcctggtac atggggcagg
     2761 cagtcctgcg acaaaagcga agatcccttg aaacctgggc tcttggccag ggtgctgggt
     2821 tcagtttctt taagctaaga ctgacaaggc catgttggcc actgaggacc tgcctgctac
     2881 tgaggctcac ggtacagagg cctggctgcc ccacatccag ggcagagggt ctcccagtta
     2941 aaagactagg ttttgtaaat ttttttaaca tgtaaacctt tcaatgttga tacacaaaat
     3001 taaatctcct gataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
LOCUS       NM_001108236            5794 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus lipin 2 (Lpin2), transcript variant 3, mRNA.
ACCESSION   NM_001108236 XM_001055334 XM_237521
VERSION     NM_001108236.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5794)
  AUTHORS   Kok,B.P.C., Dyck,J.R.B., Harris,T.E. and Brindley,D.N.
  TITLE     Differential regulation of the expressions of the PGC-1alpha splice
            variants, lipins, and PPARalpha in heart compared to liver
  JOURNAL   J Lipid Res 54 (6), 1662-1677 (2013)
   PUBMED   23505321
  REMARK    GeneRIF: novel differences in the regulation of lipins 1,2,3,
            PPARalpha, and PGC-1alpha splice variants during fasting in heart
            versus liver, even though the ultimate outcome in both tissues is
            to increase FA turnover and oxidation.
REFERENCE   2  (bases 1 to 5794)
  AUTHORS   Donkor,J., Zhang,P., Wong,S., O'Loughlin,L., Dewald,J., Kok,B.P.,
            Brindley,D.N. and Reue,K.
  TITLE     A conserved serine residue is required for the phosphatidate
            phosphatase activity but not the transcriptional coactivator
            functions of lipin-1 and lipin-2
  JOURNAL   J Biol Chem 284 (43), 29968-29978 (2009)
   PUBMED   19717560
REFERENCE   3  (bases 1 to 5794)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   4  (bases 1 to 5794)
  AUTHORS   Donkor,J., Sariahmetoglu,M., Dewald,J., Brindley,D.N. and Reue,K.
  TITLE     Three mammalian lipins act as phosphatidate phosphatases with
            distinct tissue expression patterns
  JOURNAL   J Biol Chem 282 (6), 3450-3457 (2007)
   PUBMED   17158099
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474043.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055334.1, XM_237521.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132264,
                              SAMD00132295 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..5794
                     /gene="Lpin2"
                     /note="lipin 2"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
     exon            1..85
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..286
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2779
                     /gene="Lpin2"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN2"
                     /protein_id="NP_001101706.1"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
                     /translation="MNYVGQLAGQVLVTVKELYKGINQATLSGCIDVVVVRQQDGSYQ
                     CSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAY
                     LATSPIPTEDQFFKHIDPPLVKSSGNERPPQSSDVSHTLESEAVFTPSSVKKKKRRRK
                     KCKQDNRKEEQAASPVAEDVGDVAVSSDDEKRAQAARGSSNASLKEEDYKEPPPFHSG
                     DNYPLSDGDWSPLETSYPQTVCPKSDSELEVKPSESLLRSESHMEWTWGGFPESTKVS
                     KRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCK
                     QLSDAASTELPESPLEAPQISSTLDADPVPSPSAEAPSEPKPAAKVDSPTKRKGVHKR
                     SQHQGPDDIYLDDLKALEPEVAALYFPKSDTDPGSRQWPESDTFSGSQSPQSVGSAAA
                     DSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNL
                     VIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKKESMT
                     KQLPETKEGKSEVPPANDLPSGTEEPVSARPAENDTSSDEGSQELEETIKVDPISMET
                     LSHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDK
                     VIISDIDGTITKSDALGQILPQLGKDWTHQGIARLYHSINENGYKFLYCSARAIGMAD
                     MTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAP
                     SRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVE
                     HVFPLLNKEQNSAFPCPEFSSFCYWRDPIPDVDLDDLA"
     misc_feature    95..415
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    95..415
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    <1070..1543
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1070..1543
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1493..1771
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    1493..1771
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    1997..2674
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    1997..2674
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    2711..>2767
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     misc_feature    2711..>2767
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     exon            287..382
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..684
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..792
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..916
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1256
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1356
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1544
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1638
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1708
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1798
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1881
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2026
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2175
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2262
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2415
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2530
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2634
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..5794
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggggctg gcgaggtgca gttattccct caggccgttg gcttgcccgc cgccgcctcc
       61 tgcaggccgt ggaccaggtt cagattctca aaccatgaat tatgtgggcc agctggctgg
      121 gcaggtgctt gtcactgtga aggaactcta caagggcatt aaccaagcca ctctatctgg
      181 gtgcatcgat gtggtcgtgg tgcggcagca ggatggctcc tatcagtgct caccttttca
      241 cgtgcgcttc gggaagctgg gtgtcctgag gtccaaggag aaggtgattg acatagaaat
      301 caatggcagt gctgtggatc ttcacatgaa attgggtgat aatggagaag ccttctttgt
      361 agaggagact gaagaagaat atgaaaaact gcctgcttat cttgccacct caccaattcc
      421 aactgaagac cagttcttta aacatattga cccccctttg gtgaaatcaa gtggaaatga
      481 aaggccacca cagagttcag atgtttctca taccttggaa tcagaggcag ttttcactcc
      541 gagttctgtg aaaaagaaga aacggaggag aaagaagtgc aaacaggaca ataggaagga
      601 ggagcaggcg gcttcccctg ttgcagaaga tgtaggcgat gtggctgtga gctctgatga
      661 tgagaagaga gcccaggcag caagaggatc ttcaaatgct tccttaaagg aagaggacta
      721 taaggagcct ccgcctttcc attctgggga taactatccc ttatctgatg gagattggtc
      781 tccattggaa accagttacc cacagacagt gtgccccaag agtgactcgg agctggaggt
      841 gaagccatcc gagagcctcc tcagatctga gtcgcacatg gagtggacgt ggggtgggtt
      901 cccagagtcc accaaggtca gcaaaagaga aagatatgac tatcatccaa ggacagctac
      961 aattacacca tcagaaaaca ctcattttag ggtaattccc agtgaagaca gcctcataag
     1021 agaagttgag aaggatgcta ctgttgaaga tactacctgt accatagtga aacccaaacc
     1081 tcgagccctg tgtaagcaac tgagtgatgc agcttccact gaacttcctg aatcgcctct
     1141 tgaagcacct cagatctcat ctacattaga tgcagaccct gttcccagcc catcagcaga
     1201 ggctccctca gagcccaaac cagctgctaa agtagactca cctacaaaga gaaaaggtgt
     1261 tcacaaaaga agccagcacc agggacctga tgacatttac cttgatgact taaaggctct
     1321 tgagcctgaa gtggcagctc tctatttccc taaaagtgac accgatccgg gttctaggca
     1381 gtggcctgag tctgacacat tctctggttc tcagtcccca caatctgtgg gaagtgcagc
     1441 tgcagacagt ggcaccgaat gcctctcgga ttctgccatg gacttgcctg atgtaactct
     1501 ctccctctgt ggaggcctca gtgagaatgg agagatttct aaagagaagt tcatggagca
     1561 catcatcacg taccacgagt ttgcagagaa ccctggcctt atcgacaacc cgaaccttgt
     1621 gatccggatc tataaccgtt actacaactg ggcgttggct gctcccatga tccttagctt
     1681 acaggtattt cagaagagtc tgcctaaggc cacagtcgag tcctgggtta aagacaagat
     1741 gccgaagaaa tctggccggt ggtggttttg gcgaaagaaa gaaagcatga ccaaacagtt
     1801 gccggagacc aaggagggga aatctgaggt ccctccagca aatgacctgc cttccggtac
     1861 tgaggagccc gtcagtgcca gacctgcaga gaatgacact tctagtgacg aggggtcaca
     1921 ggagttagaa gaaaccatca aagttgaccc catctcgatg gagacattga gtcactgtgg
     1981 aacagcctca tataagaagt ctctccgact gtcctcggac cagatagcaa aactgaaact
     2041 ccacgatggc cccaatgatg ttgtattcag tatcacaacc cagtatcagg gcacctgtcg
     2101 gtgtgcgggt accatttacc tgtggaactg gaatgacaaa gtcatcattt ctgacatcga
     2161 tggaacaata accaagtctg atgctttggg acagattctc ccacagctgg gtaaagactg
     2221 gactcatcag ggcatagcta ggctctacca ttccatcaat gagaatggtt acaagtttct
     2281 gtactgttct gcacgcgcca tcggcatggc cgacatgacc cgtggctatt tacactgggt
     2341 caatgacaag ggcacaatct tgcctcgagg ccccctgatg ctgtccccca gcagcttgtt
     2401 ctctgccttc cacagggaag tgatagaaaa gaaaccagag aagttcaaaa ttgagtgtct
     2461 gaatgatatt aagaacttgt ttgccccatc caggcagccc ttctatgctg cctttggaaa
     2521 ccgtcccaac gatgtctatg cttacacaca agtcggagtt ccagactgta ggatattcac
     2581 tgtgaatcca aagggtgaat taatacaaga aaggaccaaa ggaaacaagt catcgtatca
     2641 caggctgagt gagcttgtgg aacacgtgtt cccacttctc aataaggaac agaattctgc
     2701 cttcccatgc ccagagttca gttccttctg ctactggaga gacccaatcc ctgacgtgga
     2761 cctggatgac ctagcttgaa aaaggcctgt ggcaaggtgg gggcactgtc actcacctcc
     2821 cagcagggaa ggtcactggc cctcttacag atgaagaccc aggagctgac aggaacctgc
     2881 tttccagaac agggacagag tccccgaagc tggcactgcc accttctttc agcttcctaa
     2941 gccaccactc agcacctaga cagaggagta aggggcagtc agcctgcatt agaagcctgt
     3001 gctctgaagc ctgtgctcca ttacttgtgg gcctcacatg cctcttgtgg agttgtgtgc
     3061 tgtgcactgg tcagctgcat agtttaaaaa ggaagaaacc agaaactcaa aaagaacaga
     3121 ccagcacatg actacacaaa gtaaagagtt aaaatctcca ctggtcagtt gggatcgttt
     3181 ctctctataa acagggcttt ctgcagaggt ccagttagtg ctgccagctg tgtgtacatg
     3241 tcctcctccg gacacctcca ctcctgctca ctgaactagg acagctgctt catgtgccag
     3301 gcaggcagcg ccagcacctt gagcccagct gcgccagcgt gggctgtaaa gttgggggaa
     3361 ggcagcctag cagcaccatc tcctcgctga gaaggaagtc gtttaggttg tcgttatgac
     3421 ctagcagaag aacaggtgca tatttcatgt ctggagtaac agtgaggcct tggtttaaat
     3481 cacaggagag gcagtggctt tcctcagaag tgtagggcag ttgccttggg ccttgggagt
     3541 cctgttctct gacactgtca ctgccttagg tggtccttgg ggcaggtatt tcaggacagg
     3601 atttttgaaa gtctgggctt cagatttgct aaggaaaaag cctttggctg gtggcattga
     3661 ccagtccttt gaactccagc cacataagaa gtccatggag gcgtgggaga gagggcactg
     3721 agtgcccgtt gagagcgagc accgcggcag gagcccagcc cacctgattc acctgtcagc
     3781 tctgaccctc atgcagttga tagtgggcta cccctgcacc tcgctgcacc tcgctggcag
     3841 caccagacac tggcctagtt aagtgcttgt caatgttgga acacacagca ccagggagag
     3901 ttttgtcctc agatctgcag agccgggacc agctgggtgt ggacagtcac tgcagtgctc
     3961 acatcgagaa gtactgaagg agggcgttcc agagacctca gtggttcagt cacaacctcc
     4021 cctgggaaga tggccgtggc ggcttctgag cagaggggga gccgccctta aagctgttcc
     4081 aaccctgcat gccctgcagc tggatggctg gcctgaccag gcttcagttt gcttcactca
     4141 aaataacgct cgcctagagt tggcttagaa aaggggtggt tattttccag attggagagt
     4201 tgagtgtccc tgcctcattt cagtattgca gttgaatgca gagaccatgg ttgacaatgt
     4261 ttaattaaag aaaaaaagga ccatgtgaag cacagttctc agtggcaaac ctgaaggtac
     4321 atgctcccag agaaggggcc acacaggctt ccacagctga tgtttcccat acaattcact
     4381 tctccttcgt gagttatctg tgttaggtag tagggaaact cagttacgtt tatgtgaaat
     4441 tcttgccggt tagtgaaata agatcctatt aaagcagcca cgtgggattt gatgcccaag
     4501 ccatcagtac cttggtggtg tagcacatct tcgctttagg gaagcagaat tgtgtactta
     4561 acctgagctt ggtaggatct cgtggtacag aatgtctttt atgttttctc tcagaccact
     4621 tctgtttgtc ctttagggag ctttttacct agctagtctg tttgcttttc ctgacaaact
     4681 cttttttttt tttttttttt ttttttggac acatgggcct cttcagaagg tccagcatag
     4741 gctctgggtc tcttggcctg tgccgagagg gtggctggtc tttctgtccg tctgtgtgtc
     4801 tgttagcccg acacttgtca ctgcacattg atcagtgaat atttaggata atgaatgtaa
     4861 ctctttcctt atttaaagga gtcttccttg ctgaaagtag atgattactg ttactgtagt
     4921 gttatgagtg ttaggtttgt gctgaaaatc cattgccatt tgttacaaat gacatttgtt
     4981 ctttctgtga aagagagatg cccttaagtg tgtttgcaca caaaccctta gatggcttgt
     5041 tgcagtgtca ccttgtcttc agtgacaggt gatgctgaag agacactatg gcagaccagc
     5101 cacccgtccc tccatcagtg ttgcatcagt gactacggcc ccatgtcttt ccagttcagt
     5161 ctaatgttag tgtctggtgt cgagtgttgg cacttccact gctgtggaag tgatggctgc
     5221 tctccctgtg gaggttgtac atgtggacct ggagcacaca cacgtaaccg tatgatcagt
     5281 actgcatttc ctgtggtcta tctgcatagt cagttggaaa aagaaatgtg ttggtgtagt
     5341 aacgtaaaaa caaaagctgc taaaacagcc tagagtgggt caggaccaca gctgagcagc
     5401 agggagcctc tgtcctgtgc agcccctgtc catggggcgg gtccggcctt ctgtagtgct
     5461 cttcaaagcc atcatccgag agaagaagcg gttaaggtga cgagcgagtt tatcacatag
     5521 ccctgggaaa ccttgtttga gagcacgctg gggtttatgc aaaacttgaa ggcagaggaa
     5581 agacttccct tttaataatt acactcagct gatgaaggac ttgattatta gagagcagcc
     5641 actgagcagc tttcagtcgt cagtaatgaa ttgtaaacat cagtgcagta ccttcaatgt
     5701 ggtacagaag ttgtcttcag atgaacggct catgttttgg tgcagtgttt gatgttcaca
     5761 aaaatgttac aataataaac taacgtgaac tgag
//
LOCUS       NM_001437634           12519 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4),
            transcript variant 1, mRNA.
ACCESSION   NM_001437634 XM_039084150
VERSION     NM_001437634.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12519)
  AUTHORS   Zhang,S., Hu,S., Dong,W., Huang,S., Jiao,Z., Hu,Z., Dai,S., Yi,Y.,
            Gong,X., Li,K., Wang,H. and Xu,D.
  TITLE     Prenatal dexamethasone exposure induces anxiety- and
            depressive-like behavior of male offspring rats through
            intrauterine programming of the activation of NRG1-ErbB4 signaling
            in hippocampal PV interneurons
  JOURNAL   Cell Biol Toxicol 39 (3), 657-678 (2023)
   PUBMED   34189720
REFERENCE   2  (bases 1 to 12519)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   3  (bases 1 to 12519)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12519)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   5  (bases 1 to 12519)
  AUTHORS   Chen,J.L., Zhou,X., Ding,H.L., Zhan,H.L., Yang,F., Li,W.B.,
            Xie,J.C., Liu,X.G., Xu,Y.C., Su,M.Z., Liu,B.L. and Zhou,X.F.
  TITLE     Neuregulin-1-ErbB signaling promotes microglia activation
            contributing to mechanical allodynia of cyclophosphamide-induced
            cystitis
  JOURNAL   Neurourol Urodyn 38 (5), 1250-1260 (2019)
   PUBMED   30989724
REFERENCE   6  (bases 1 to 12519)
  AUTHORS   Carroll,S.L., Miller,M.L., Frohnert,P.W., Kim,S.S. and Corbett,J.A.
  TITLE     Expression of neuregulins and their putative receptors, ErbB2 and
            ErbB3, is induced during Wallerian degeneration
  JOURNAL   J Neurosci 17 (5), 1642-1659 (1997)
   PUBMED   9030624
REFERENCE   7  (bases 1 to 12519)
  AUTHORS   Riese,D.J., Kim,E.D., Elenius,K., Buckley,S., Klagsbrun,M.,
            Plowman,G.D. and Stern,D.F.
  TITLE     The epidermal growth factor receptor couples transforming growth
            factor-alpha, heparin-binding epidermal growth factor-like factor,
            and amphiregulin to Neu, ErbB-3, and ErbB-4
  JOURNAL   J Biol Chem 271 (33), 20047-20052 (1996)
   PUBMED   8702723
REFERENCE   8  (bases 1 to 12519)
  AUTHORS   Cohen,B.D., Green,J.M., Foy,L. and Fell,H.P.
  TITLE     HER4-mediated biological and biochemical properties in NIH 3T3
            cells. Evidence for HER1-HER4 heterodimers
  JOURNAL   J Biol Chem 271 (9), 4813-4818 (1996)
   PUBMED   8617750
REFERENCE   9  (bases 1 to 12519)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   10 (bases 1 to 12519)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 7, 2025 this sequence version replaced XM_039084150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY375307.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               JAXUCZ010000009.1  78045492-78046365   c
            875-1026            JAXUCZ010000009.1  77652717-77652868   c
            1027-1213           JAXUCZ010000009.1  77486353-77486539   c
            1214-1348           JAXUCZ010000009.1  77329931-77330065   c
            1349-1414           JAXUCZ010000009.1  77297827-77297892   c
            1415-1533           JAXUCZ010000009.1  77277927-77278045   c
            1534-1675           JAXUCZ010000009.1  77274999-77275140   c
            1676-1789           JAXUCZ010000009.1  77272312-77272425   c
            1790-1916           JAXUCZ010000009.1  77265268-77265394   c
            1917-1990           JAXUCZ010000009.1  77258501-77258574   c
            1991-2081           JAXUCZ010000009.1  77257410-77257500   c
            2082-2281           JAXUCZ010000009.1  77250459-77250658   c
            2282-2414           JAXUCZ010000009.1  77241085-77241217   c
            2415-2508           JAXUCZ010000009.1  77233398-77233491   c
            2509-2663           JAXUCZ010000009.1  77226370-77226524   c
            2664-2738           JAXUCZ010000009.1  77218392-77218466   c
            2739-2871           JAXUCZ010000009.1  77189578-77189710   c
            2872-2994           JAXUCZ010000009.1  77186058-77186180   c
            2995-3093           JAXUCZ010000009.1  77182095-77182193   c
            3094-3279           JAXUCZ010000009.1  77138089-77138274   c
            3280-3435           JAXUCZ010000009.1  77019981-77020136   c
            3436-3511           JAXUCZ010000009.1  77017863-77017938   c
            3512-3658           JAXUCZ010000009.1  77015123-77015269   c
            3659-3756           JAXUCZ010000009.1  77012776-77012873   c
            3757-3927           JAXUCZ010000009.1  77010899-77011069   c
            3928-4225           JAXUCZ010000009.1  76983351-76983648   c
            4226-12519          JAXUCZ010000009.1  76973386-76981679   c
FEATURES             Location/Qualifiers
     source          1..12519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32-q33"
     gene            1..12519
                     /gene="Erbb4"
                     /note="erb-b2 receptor tyrosine kinase 4"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
     exon            1..874
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    778..780
                     /gene="Erbb4"
                     /note="upstream in-frame stop codon"
     CDS             793..4671
                     /gene="Erbb4"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor tyrosine-protein kinase erbB-4;
                     c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor
                     tyrosine kinase; v-erb-a erythroblastic leukemia viral
                     oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia
                     viral oncogene 4"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-4 isoform
                     1 precursor"
                     /protein_id="NP_001424563.1"
                     /db_xref="GeneID:59323"
                     /db_xref="RGD:620486"
                     /translation="MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQ
                     QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENL
                     RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
                     IHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
                     GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
                     HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
                     DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVF
                     RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
                     KEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCS
                     NDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGL
                     LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG
                     CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKK
                     KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
                     GETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQL
                     MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
                     VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
                     TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
                     EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
                     PPPIYTSRTRIDSNRNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDD
                     SCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERNPRAELDEEGYMTPMHDKPKQEY
                     LNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVNEPLYLNTFTNALGNAE
                     YMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIV
                     AENPEYLSEFSLKPGTMLPPPPYRHRNTVV"
     sig_peptide     793..867
                     /gene="Erbb4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    955..1293
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    955..1293
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1204..1206
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1312..1314
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1348..1788
                     /gene="Erbb4"
                     /note="Furin-like cysteine rich region; Region:
                     Furin-like; pfam00757"
                     /db_xref="CDD:395614"
     misc_feature    1348..1788
                     /gene="Erbb4"
                     /note="Furin-like cysteine rich region; Region:
                     Furin-like; pfam00757"
                     /db_xref="CDD:395614"
     misc_feature    1549..1551
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    1864..2226
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1864..2226
                     /gene="Erbb4"
                     /note="Receptor L domain; Region: Recep_L_domain;
                     pfam01030"
                     /db_xref="CDD:460032"
     misc_feature    1864..1866
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2020..2022
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2209..2211
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2275..2277
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2296..2694
                     /gene="Erbb4"
                     /note="Growth factor receptor domain IV; Region:
                     GF_recep_IV; pfam14843"
                     /db_xref="CDD:464344"
     misc_feature    2296..2694
                     /gene="Erbb4"
                     /note="Growth factor receptor domain IV; Region:
                     GF_recep_IV; pfam14843"
                     /db_xref="CDD:464344"
     misc_feature    2434..2436
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2518..2520
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2650..2652
                     /gene="Erbb4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); glycosylation site"
     misc_feature    2716..2847
                     /gene="Erbb4"
                     /note="Transmembrane domain of ErbB4, a Protein Tyrosine
                     Kinase; Region: TM_ErbB4; cd12092"
                     /db_xref="CDD:213053"
     misc_feature    2716..2847
                     /gene="Erbb4"
                     /note="Transmembrane domain of ErbB4, a Protein Tyrosine
                     Kinase; Region: TM_ErbB4; cd12092"
                     /db_xref="CDD:213053"
     misc_feature    order(2716..2721,2725..2736,2743..2748,2755..2760,
                     2767..2772,2779..2784,2791..2793,2803..2805)
                     /gene="Erbb4"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213053"
     misc_feature    order(2716..2721,2725..2736,2743..2748,2755..2760,
                     2767..2772,2779..2784,2791..2793,2803..2805)
                     /gene="Erbb4"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213053"
     misc_feature    2746..2817
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     transmembrane region"
     misc_feature    2818..2844
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    2920..3828
                     /gene="Erbb4"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     HER4; Region: PTKc_HER4; cd05110"
                     /db_xref="CDD:173655"
     misc_feature    2920..3828
                     /gene="Erbb4"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     HER4; Region: PTKc_HER4; cd05110"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375,3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="active site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375,3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="active site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375)
                     /gene="Erbb4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    order(2962..2967,2986..2988,3037..3039,3043..3045,
                     3106..3108,3172..3174,3178..3183,3187..3189,3331..3336,
                     3340..3342,3373..3375)
                     /gene="Erbb4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    3370..3447
                     /gene="Erbb4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173655"
     misc_feature    3370..3447
                     /gene="Erbb4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173655"
     misc_feature    3415..3417
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    order(3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    order(3436..3450,3463..3465,3475..3477)
                     /gene="Erbb4"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:173655"
     misc_feature    3886..3897
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PPxy motif 1"
     misc_feature    3895..3897
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4192..4194
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4228..4230
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4306..4308
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4348..4350
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4468..4470
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4516..4518
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4594..4596
                     /gene="Erbb4"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q15303; propagated from
                     UniProtKB/Swiss-Prot (Q62956.3); phosphorylation site"
     misc_feature    4636..4647
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PPxY motif 2"
     misc_feature    4660..4668
                     /gene="Erbb4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62956.3);
                     Region: PDZ-binding"
     exon            875..1026
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1213
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1348
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1414
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1533
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1675
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1789
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1916
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1990
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2081
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2281
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2414
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2508
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2663
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2738
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2871
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2994
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3093
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3279
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3435
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3511
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3658
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3756
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3927
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4225
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..12519
                     /gene="Erbb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaaagc ctggctggtt gcgtggaggg ttgtttgatt cccaccccca ctcccctctt
       61 tttttctttc ttttcttttc ttttcttttt taaaaaatct ttctccctga gtcttattaa
      121 tttctctgtg gggctgcggc tggagaccgc ggagcgttgg aaatgacgct cggagcttta
      181 attactgcaa tggctggaca agtgtgagga aagctgacag tggaaaaaaa ggggcacagg
      241 atcggggaga aggaaagaag caccccccct ccttttccct ccagatttgg acaggagatg
      301 caaggagact gaagagagag ctgaacatag cctggttttg gggggagagg ccggaaccct
      361 gccgcctctt cgcaatcaac tttttttgga agcctttatt ccccctcttt ctttttattg
      421 ttgaccaacc agtgagaagg agagagagcg agcgagaaag tgaggagtga acgggcgagc
      481 agaggatcac tccggaaact agctgtacgg ttgtgctcgg agcaccagcc gcacagtcgc
      541 gcacactccc atccgcgcgc cctccttcgc ggccccttgc tgggtccgcg ggtccccggg
      601 tcctggaagc cgccaccagc gccgactggc tcgccaaccc cgggaagccc gtgcacagag
      661 cgcgccgcgc ccgcccccct cgcgcccccc acgcgctccc ggctgagggg gggagatctc
      721 ctccgcgtgc ccgcaagtgg ctatggtatt tggacatgta attgtcagcg cgggatctga
      781 gacttgccaa aaatgaagct ggcgacggga ctgtgggtct gggggagcct tctggtggca
      841 gccaggaccg tccagcccag cgcttctcag tcagtgtgtg ccggaacaga gaacaaactg
      901 agctctctct ctgatctgga gcagcagtac cgagccttgc gcaaatacta tgaaaactgc
      961 gaggtagtca tgggcaacct ggagatcacc agcatagagc acaaccggga cctctccttc
     1021 ctgcggtcta tccgagaagt cacaggctat gtacttgtgg ccctcaacca gtttcgttac
     1081 ctgcctctgg agaatttacg cattattcgt gggacaaaac tgtatgaaga tcgctatgcc
     1141 ttagcaatat tcttaaacta caggaaagat ggcaactttg gacttcaaga actgggatta
     1201 aagaacctga ccgaaatact aaatggtgga gtctatgtag accagaacaa attcctatgt
     1261 tatgctgata ctatacactg gcaagatatt gttcggaatc catggccttc caacatgact
     1321 ctggtgtcaa caattggaag ttctggatgc ggaagatgcc ataagtcttg cactggtcga
     1381 tgctggggac ccacagaaaa tcactgccag accttgacca ggactgtgtg tgctgaacaa
     1441 tgtgatggca ggtgctatgg accctacgtc agtgactgct gccatcgaga atgtgccgga
     1501 ggctgctcag gaccaaaaga cactgactgc tttgcctgca tgaacttcaa tgacagtgga
     1561 gcctgtgtta ctcagtgtcc ccaaacgttc gtctacaatc caaccacctt tcaactggaa
     1621 cacaacttca atgcaaagta cacatatgga gcattctgtg ttaagaaatg tccacataac
     1681 ttcgtggtag attccagttc ttgtgtacga gcctgcccta gttccaagat ggaagtcgaa
     1741 gaaaatggaa ttaaaatgtg taagccttgc actgatattt gccccaaagc atgtgatgga
     1801 atcggcaccg gatccttgat gtctgctcag actgtggatt ccagtaacat tgacaaattc
     1861 ataaactgca ccaagatcaa cgggaatctc atctttcttg tcactggcat tcatggtgac
     1921 ccttacaatg ctattgacgc catagaccca gagaaactga atgtctttcg gacagtcaga
     1981 gaaataacag gtttcctgaa catacaatct tggcccccaa atatgacaga tttcagtgtt
     2041 ttctccaacc ttgtaaccat tggaggaaga gtcctctaca gtggtctctc attgcttatc
     2101 ctcaaacaac aaggtatcac ttcactacag ttccagtctc tgaaggaaat cagtgcgggc
     2161 aatatctaca tcacggacaa cagcaacctg tgttattacc acaccatcaa ctggacaaca
     2221 ctgttcagca ccgttaacca gaggatagtg atccgagaca acaggagggc tgagaactgt
     2281 actgctgaag ggatggtgtg taaccacctg tgttcaaatg atggttgttg gggacctggg
     2341 ccagaccagt gtctgtcatg tcggcgcttc agcaggggaa agatctgtat agagtcctgc
     2401 aacctttatg atggggagtt tcgagagttt gaaaacggct ccatctgtgt tgagtgtgac
     2461 tcccagtgtg agaaaatgga agacggactc ctcacatgcc atggaccggg acctgacaac
     2521 tgtacaaagt gttctcattt taaagatggt cctaactgtg tagagaaatg tccagatggc
     2581 ctacagggag caaacagttt catatttaag tacgcagatc aggatcggga gtgccaccct
     2641 tgccatccaa actgcaccca ggggtgtaac ggtcccacta gtcatgactg catttactac
     2701 ccatggacgg gccattccac tttaccacaa catgctagaa ctccactgat tgcagccgga
     2761 gtcattggag ggctcttcat cctggtcatc atggctctga catttgccgt ttatgtcaga
     2821 aggaagagca tcaaaaagaa acgcgctttg agaagattcc tggagacaga gctagtcgag
     2881 cccttaaccc ctagtggcac agcacccaat caagctcaac ttcgaatttt gaaggaaaca
     2941 gagctaaaga gggtaaaagt ccttggctcg ggagcatttg gaaccgttta taaaggaatc
     3001 tgggtgcctg aaggtgaaac tgtgaaaatc cctgtggcta ttaagatcct caatgagaca
     3061 actggcccca aagccaatgt ggagttcatg gatgaggcac tgattatggc aagtgtggat
     3121 cacccacacc tagtgcgttt actgggtgtg tgtctgagcc ccactatcca gttggttact
     3181 cagttgatgc cacatggctg cctactggaa tatgtccacg aacacaagga taacatcgga
     3241 tcacagctgc tgttgaactg gtgtgtccag attgctaagg gaatgatgta tctggaggaa
     3301 aggcggcttg ttcatcggga tctggcagcc cgcaatgtgt tggtgaaatc tccaaatcat
     3361 gttaaaatca cagactttgg actggcccgg ctcttggaag gagatgaaaa agaatacaat
     3421 gctgacggtg gcaagatgcc aattaaatgg atggctctgg aatgtataca ttataggaaa
     3481 ttcacacatc aaagcgatgt ttggagctac ggtgtcacta tatgggaact gatgaccttt
     3541 ggaggaaagc cctatgatgg aattccaacg cgagaaatcc ctgacttatt agagaaggga
     3601 gagcgtttgc ctcaacctcc catctgcact attgacgttt acatggtcat ggtcaaatgt
     3661 tggatgatcg atgctgacag cagacctaaa ttcaaagaac tggctgctga gttttcaagg
     3721 atggctagag accctcaaag atacctagta attcaggggg atgatcgcat gaagcttccc
     3781 agtccaaacg acagcaaatt cttccagaat ctcttggatg aagaggattt ggaagatatg
     3841 atggacgctg aggaatattt ggtcccccag gctttcaata tcccacctcc tatctacaca
     3901 tccagaacaa gaattgactc caataggaat cagtttgtgt accaggatgg gggtttcgct
     3961 acacaacaag gaatgcccat gccctaccga gccacaacca gcaccatacc agaggctcca
     4021 gtcgcccagg gtgcaacggc tgagatgttt gatgactcct gctgtaatgg taccctgcga
     4081 aagccagtgg taccccacgt ccaagaggac agtagcactc agaggtatag tgccgacccc
     4141 acagtgttcg ccccagaacg gaaccctcga gcagaactgg atgaagaagg ctacatgact
     4201 cccatgcatg acaagccaaa acaagaatat ctgaatcctg tggaagagaa cccttttgtg
     4261 tcccggagga agaatggaga ccttcaagct ttagataatc cagagtatca cagcgcttcc
     4321 agcggtcccc ccaaggcaga ggatgagtac gtgaatgagc ccctttatct caacaccttc
     4381 accaacgcct tgggaaatgc agagtacatg aaaaacagct tactgtctgt gccagagaaa
     4441 gccaagaaag catttgacaa ccccgactac tggaaccaca gcctgccacc ccggagcact
     4501 cttcagcacc cagactacct gcaggaatac agcacaaaat atttttataa acagaatgga
     4561 cggatccgcc ctattgtggc agagaatcct gagtacctct cagagttctc gctgaagcca
     4621 ggcactatgc tgccccctcc gccctacaga caccggaata ctgtggtgtg agctcagcta
     4681 gagtgttagg tggagaaaca cacacccgct ccatttccct tctccctcct ctttctctgg
     4741 cagtcttcct tcttctccca aggccagtag ttttgacact tccgagtgga agccgtagag
     4801 acgcaatgat agttccgtgc ttacctaact tgaatattag aaggaaagac tgaaagagaa
     4861 agacagaggg gcacacactg tttcttcatt tcttcatatg ggttggttaa cagagtgtct
     4921 gtcagagcta gagaaggtct aggaagtgta aggcaatacc aataccgcct gctgtcaaag
     4981 agccccatct ttgttctctt tgcactctgc actctctccc tccttctctc cctgtcccca
     5041 tctcccttta atctatcaat gctggtgatg atcggaagcc cagactctgt tctaatctgt
     5101 agccatagtc ttgtgcatat tcaagcatcc ctgaaatcat tctaaggctt ccattagaac
     5161 aaaaagataa gcagttggac accatttgat agtaactgag attgagaagc caatttcttt
     5221 ctccaatagt ttctttcttg gcaagtaaga atggccaatc cagcttttgt gaattttaaa
     5281 tctccattat agttataact ggcaattatg cttggaaggc atctctgtgt acttcttttc
     5341 aattttggtt tgctttggcc tattccttta tatcagttgc tccccttttg gctgcagttt
     5401 ctaattgtaa agaggtttac ataaaggcct cttgacagac ttcaaacaaa aacatatgat
     5461 acgatgtaga gattgttatt ttaaatcatt cagtccttaa aactagaaga gaaagccaag
     5521 atagtagtaa aaaatagtat caaaactaga tctcatgttt cacactactg agtttcgtct
     5581 tccctttcgt tttcattctt taccatttta ttcttccccc agaaggcttg acaaggcagt
     5641 gggaatctta ggagtagaag ggatgctaag aaacaggtct gtgtggttca caaaactact
     5701 gaaactttca gggtggtccc gtgggggatc catgcagtgg gagaaacact ggattgggta
     5761 cgtctacatg gaaggtactc agaaatgtag tttgcactta agctataatt ttatttgttc
     5821 tttttctgaa caccactttg gatttttgaa tgaagcaata tggaagcaac cagcagatta
     5881 actaatttaa gtacttcatt ttaaaaaaaa aaaaggatgt aagataaaga cagactgtgg
     5941 aaataccaaa ccaagccaat taggactttg gaacagtacc cagggattgt ggtgagaggg
     6001 tcagcacatt accttcatat gatgtgacat ttgctgtgta aggaagtatg ttaagtttat
     6061 actctctgtg tgaacggatg caagttaagg actggcgtga attccataga gattctggaa
     6121 tgacattctg tttatattga ctaggtgact taactcttca cacctaagtt gctataatta
     6181 aaagcaaacc atcaacattt gaagcctatg aataggtcca tgcttgagtt aaaagttgta
     6241 aataaacatg aaaacccttc tcacgcaatt attttattat ccagtatatt aatcttttaa
     6301 taatttatgt aatgactctt tcttcatata ctaccatact atgtccaggt tgtagatccc
     6361 tctgataggt ttaattttga aaaagcacct atagtgttaa ggttagtgat ggggacagtg
     6421 acaaatgaat ctttaggaaa taaggaaaca atacatctct cttttctaca aaattctcct
     6481 ccaagtcttt taggttttta aacatttctt tctactgtta aagttttgag agaacattag
     6541 attcactagc aaaaaaataa tcaattagat taaaaatctt ctcagtaaaa tagagagtac
     6601 ttaagggaga aaattctcaa gggagtttac gtttctacct attttgaaaa agtaaacccg
     6661 tgcatccaaa tctagaatca ttcaactgat attaaaagtc tactgaaagt atgtggggga
     6721 taagtgaaac catccctgac ttcaaatttt aacaatctag atttatttgc tgtgacattc
     6781 ttatttctct atgagtccaa ggaatcagat tgtattagct attttgtgaa tggatacatg
     6841 gaacattttg taaaagtttt cagaagtcat tgggatatat tttaaacatc cttcaagcta
     6901 ctgaagatga caaatataat cgcctctgtg ttctttctca gacacaaacc ggaccacatg
     6961 agcattacat cactggcaaa ctgatatatc tggagtgttg ccataaaatc agggcaaact
     7021 cctgggaagt gttgggtttg ttctcttctt cagggaagag atggcaagcg aactgaaagt
     7081 gagagttgga aagagcagag gggtctgtga gatcctgtct agaggaattt agccatgaat
     7141 ttaccagatg cagaatgatc cggggggcca cagcctgaaa acccaaagtt caccccaatt
     7201 cagaggcatc cactaagaca agggacctta tataagtacc tatttccctt aaagtaagcc
     7261 tctgttagta aataaatcta tacctaacca ttactgtcag caccttgaaa tgctacaagg
     7321 actttttctt atcacttaaa atatccccgt ggcttctagt gggataaaga aagcaattat
     7381 ttcattagta aatgaaagga gataatctcc tagctgttaa ttcaatgtaa atgtagtcaa
     7441 tgagggttgc ccttttcttc cctataagca caggatttgc agttccactc atcttcccct
     7501 agatgcaggt ttgagggaga atgaccccaa gtgccatttt tatcattcct ttgtatgact
     7561 ttttaatata tacttgattt cagtttttct ggtatttctt gtttatttag atttgactac
     7621 ctaggccctg aattctaggg gacattattc aagtatgtat taatgggaca acaagtagga
     7681 atcatggagg atgtacactc atttgcttaa gagaacaaca tgtttaaccc cgtaaaatga
     7741 aactgtaaaa caccaatact aagcttgtag attatggaat agcaggtccc aagactgggc
     7801 agcaccaatc aaaatatgca ggatctattt gtaaagcagt aaaattaatg ttaaatttga
     7861 gcttcttatc ttttttaaat catcaaattg taacgatcaa gcttatcttg ggaaatccta
     7921 ctttcaggga ggaaaatttt tttagccact taaagaagcc agtcttgagc agagaaaagt
     7981 tgggggaagt tcagagctac caaagtgctg ctattcaagc aaagttgata acaaagctat
     8041 gcccagctga actaactaca ttcgcagcac agattaggta tggatcactc tctctagaag
     8101 cattcttgaa gagatgtgga aacaatgcaa attgcaaact attaaaaaaa aagaaagatg
     8161 gaagacttac taaaacaaac aaacaaacaa aaaaaaccaa aaaatggaag actcactaag
     8221 tatgaacctg cttttcatag gtcacgaaga atgtctgata ggccctatct tgaaaaagaa
     8281 atgggggact tctaagtgag acactgtcat gtcctatacc tttggagaat gacacatatt
     8341 gtcaatggtg gagaaaaaag gagggatatg aggcttcatg aatagatgaa gttagtggaa
     8401 taagtggtgg agttcctgaa gggtcaaaac tagaaagagt aaacaaacgt gtttatgcct
     8461 gtgcctgaca cagaaagttg taaatacaag attctcttga acgggtttaa cctttattta
     8521 aaaactggaa tttgttgtcc acctgtaagt gttgattatt taactagtac acgtagctca
     8581 taaggtaata aaaatggtga ccatgcaagc atgtgtacaa ttggacacaa tcatgacaat
     8641 gctctaagac atagaattca ctaggctagc agatgttaaa tgctttcaat agtaatgacc
     8701 aaattaaatt agaaaaacta gcaaggagca taaaataaca ataaaattca gactttgaaa
     8761 acgtaggatg gattttgcgt agtaaataag tttcccattt aaatggttat ttgttggagt
     8821 tagcagatag caggaatagt gatgtttcac gtgtaaagac tggctttata gtgctacagt
     8881 cgatttttct catgtcctct tagcccttcg tttcatttta attcattaag tataaagtga
     8941 tgctgtattt ggggactctg gtttgcagat atcactttga agggtttaac aggcaaataa
     9001 accacaggag aatttaagag acctttataa tgaataatgg aaattttcaa aaagggtcta
     9061 ttgcctttcg cagttgcgga aaaaaaatgt gtgcttaccc cagtggttta gaaagcaagc
     9121 aaaatattta atttgtgaag tgtcctttct tttcctacca tcttgcagat ataaccaata
     9181 tggaacccat tttcactttt attgttacta tttttttgat aaatagatgc ctaaccaaga
     9241 attttaagct attctattgg tgttcttttg gactctagtt ttttttaact gtttatttgt
     9301 tatggagcaa ataggaaatc caagagcaga gctatgagca gttaaaaagc cagacaaacc
     9361 aatttctact gcatgtatca tgggcacaga atccggttgt gcctctctgt atctgaggga
     9421 cagtcttata ctggtgtaga cacgcaatgg caggctgtca tcccctgctg accattggtt
     9481 catgaccaaa tgatatatga atataagtgt gaatccgaca taattttaaa agatctttga
     9541 cagttcagac cttctccatg atgactctaa gatgaggcca gcatttacat tttctggttg
     9601 gacacctttt tctaagccca gagttgcctt tgaaggtgtt ctctctcctg ttataaacat
     9661 gaagatttga acattgtatc aggccaggtg cccttgtgtt tgtgtatata aatccatcca
     9721 acacaagaca ctgctttgct tctccactaa atgaaacttg ataaaatgtt aagactttcc
     9781 gactctctct gttcaagtcc cactcactta atcaggagac aaaagtgtgt ggtgtgtctc
     9841 acctcactcc tggccgagag atggtttagg cacagaaaaa tgcttctagt gccacaggct
     9901 gtaaagacta tataagcccc aatgttaagg gaagatatcc atgcctcccc tggaaagaaa
     9961 tcccttgaaa gccaactttg caagtaagtg atcaccttgt cataaatagg acattgtgtt
    10021 tccctcggaa cgtttagagg aaaatagcat ctttactttc ccacccccaa ctctcacaat
    10081 gcctttgcca tgtttttttc tatcacaagt tcaaagtggc tttcctgggg taccactttc
    10141 ttaagccata gtggatctct gaagaaccac atcctcttct gaaacactga cccagccttt
    10201 gcctccaaat gcctgatggt tttttttcca ttaaaatatc taaccactct agaaggtgtt
    10261 taaattgctt ctcaaacaaa agacagcaca aaagatatat atattgttta gggtgttaag
    10321 attgtttttt cgtgacaatt gattctatca ctgtgggctt ctctatagga ttttaagatt
    10381 agttagctct gtaatgaatc ttaagactct cattgtatgt acatacactt ctagatctta
    10441 cattaatctt tccatgaaaa ctatatatgt gtatatatag tttttatgta tgtatataaa
    10501 actaagttat tgccgccaac taacttattt cctttgatca ccttatttta tttctgatat
    10561 aaatatttta cagctgctag agttttgggg tttttttttc caaatgaaga gttttattat
    10621 cacgaaggta aaggcaattc acctgtgcga acctcctgtg actcttgttg gaacatccat
    10681 ctatctaaca aatttataat aagcaccgtt tcactgtaat gaaagtctgt gttgactgac
    10741 agaactctat ctactctttc tctactttag gaggaatttt tccttttaat actttagtgt
    10801 gtcttcccct tgtcactaaa agtgtttata tttgtataga taaacaagta caagaaaacg
    10861 agcttttgca tctgtaggca atagtcgaat ttgtccaaac cactttgtct ttactgctac
    10921 ttttatccct gatatgttga tgttttcccc gggcctgtta cctttttgaa gaaaagcaaa
    10981 ccacactccc tctctattga cagaaatccg atgttcaagt atcatttcca gtgtttttcg
    11041 gttaatggag gggttgcgtc attttcctta atgtaagagt catctccctg tatagttctt
    11101 gatctctcag gggctgggag tggggagtga gggaacagct accatagaac tctaagaacc
    11161 aagaaccctt atggaattac tccggaatca gctatgaaag ttattttcta actgtagata
    11221 tatgtaagcc gttcttttta agtaaggtac tttgaaatat gtagcataaa ctggtactgc
    11281 tgttaaatgg gtcgactatt aaactgagca gctgtgcaag gggcagttaa ctttgaatgc
    11341 acaccttcct ggctagcttg tatccatctc atcacctgag caccatggcc ttcattgctg
    11401 cacaccaaga gtgtttctcc acatgctctg gctgcttgat catctctctc tcagtatcat
    11461 tagaacaaga tcaaatgtaa atggtattaa tgcgcaagat aattcatggc acacgctaaa
    11521 ctaggtcaca ttaaattttt caaaacttca tctcgtgcac gcaccacagt agttaactaa
    11581 gatcagtttg ggtgacaaag ggaggcaatt tgcagaagag gcagagttat gtctgttccc
    11641 taattttctt gacatgtaaa cagaaaacca gctctctttc ctctgaagaa tcatcaaagg
    11701 acagggctgt taaaaaaaaa aaaaaacaca acttgctggt aagccatcag tgtttcattt
    11761 aaatcccagc attcaaagtt agctgccttt tttgaaacaa acaaacaaaa actactactg
    11821 tatgtttgaa aatgtgaata gtatttttat agcttgttaa agacatggct agctgcattt
    11881 gtaaataggg ataatgttgc tttgattttc tttgatgagc atctttattt ggaacataat
    11941 tgtctttagg gttgatttgt atataagtaa ttggcttgtg attgtttctc ttttggttag
    12001 aagttatcgt tttgacatta cctgtgattc tgtgttcagc actattgtga tgtgtccaac
    12061 ctctgcactc gcttacacaa taggatatgc caattgtgtg tggtgaaatg ttattttcat
    12121 ttttttctat tttatctatg aaggattatg cacttaacac atactaactt ttttaatgtt
    12181 aggtctattt ttagtataat ttcccgattc ttctccaacc cttcagcttc ttttccctcc
    12241 tttccctatt ttctgttgtt atagaggatg agggagaaaa tgtattttaa atggatgtaa
    12301 ttaggctttt tgaggtagtt ctcaaggatc ctcttttgac tcttgggaaa gaattgtgcg
    12361 tgcacaaggc aaatatagaa tgcgagctgc tttgcctcat tccgtactga tcatcccaaa
    12421 tgaacaattt gaaaactgtt ctgccttttt gttacatgaa tctgtcagaa atatattttt
    12481 aatttaatat aaacgaaatt caataaaata tgaaacaaa
//
LOCUS       NM_001109299            2599 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus transmembrane inner ear (Tmie), transcript
            variant 2, mRNA.
ACCESSION   NM_001109299 XM_001076090 XM_576477
VERSION     NM_001109299.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Shin,M.J., Lee,J.H., Yu,D.H., Kim,H.J., Bae,K.B., Yuh,H.S.,
            Kim,M.O., Hyun,B.H., Lee,S., Park,R. and Ryoo,Z.Y.
  TITLE     Spatiotemporal expression of tmie in the inner ear of rats during
            postnatal development
  JOURNAL   Comp Med 60 (4), 288-294 (2010)
   PUBMED   20819378
  REMARK    GeneRIF: Tmie exists in the cytoplasm and may have a key role in
            the maturation and structure of stereocilia bundles in developing
            hair cells. After hair cell maturation, Tmie is thought to be
            involved in the maintenance of organ of Corti cells.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Su,M.C., Yang,J.J., Chou,M.Y., Hsin,C.H., Su,C.C. and Li,S.Y.
  TITLE     Expression and localization of Tmie in adult rat cochlea
  JOURNAL   Histochem Cell Biol 130 (1), 119-126 (2008)
   PUBMED   18327602
  REMARK    GeneRIF: Our results point out the presence and localization of
            Tmie products in the cochlea of rat.
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Naz,S., Giguere,C.M., Kohrman,D.C., Mitchem,K.L., Riazuddin,S.,
            Morell,R.J., Ramesh,A., Srisailpathy,S., Deshmukh,D., Riazuddin,S.,
            Griffith,A.J., Friedman,T.B., Smith,R.J. and Wilcox,E.R.
  TITLE     Mutations in a novel gene, TMIE, are associated with hearing loss
            linked to the DFNB6 locus
  JOURNAL   Am J Hum Genet 71 (3), 632-636 (2002)
   PUBMED   12145746
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Mitchem,K.L., Hibbard,E., Beyer,L.A., Bosom,K., Dootz,G.A.,
            Dolan,D.F., Johnson,K.R., Raphael,Y. and Kohrman,D.C.
  TITLE     Mutation of the novel gene Tmie results in sensory cell defects in
            the inner ear of spinner, a mouse model of human hearing loss DFNB6
  JOURNAL   Hum Mol Genet 11 (16), 1887-1898 (2002)
   PUBMED   12140191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576477.1, XM_001076090.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMN06680413
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2599
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="transmembrane inner ear"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
     exon            1..808
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1024
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1407
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1246..1248
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="upstream in-frame stop codon"
     CDS             1312..1773
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /codon_start=1
                     /product="transmembrane inner ear expressed protein"
                     /protein_id="NP_001102769.1"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
                     /translation="MAGRQRGSGRLWALGGAALGACLAGVASQLVEPSTAPPKPKPPP
                     LTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCRVPRTRKEIEARYLQRKAAKM
                     YTDKLETVPPLNELTEIPGEDKKKKKKDSVDTVAIKVEEDEKNEAKKKGEK"
     misc_feature    1450..1707
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="TMIE protein; Region: TMIE; pfam16038"
                     /db_xref="CDD:464987"
     misc_feature    1450..1707
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="TMIE protein; Region: TMIE; pfam16038"
                     /db_xref="CDD:464987"
     exon            1408..1525
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1675
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2599
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggcctc ggaatgtccc taagcaaaca actctctccc ccgagcctct cccgccagac
       61 ttcgaaaact cccctccggt ccgcgagcac cccgggatcg cacccaggct gtcttttcgc
      121 ctcttacctc cctctcccga tccgagaccg caggcagtgc cttacccacc gactctgagc
      181 aggctgtacc tctgagacct tgccgacccc cattgggtca cccggccctt tcacccctac
      241 acaccggcga aggagccctg ggtagattcg ggaaacttgt ttaaggcagt cggccatgat
      301 gaccccgcaa cccctggact gggggcgctt cggtagcagc cactgctgcg tgtgaccttg
      361 aaagaggccc cctgcattca ttccgggtac agcctgaatc tggccagttt cctgtgccaa
      421 agccttcgac cttggaaaga gcagcgcagt tccaaaccaa actcttggaa ggaggaggga
      481 cgatggttca aacctgtaac aaagatgcct gctgtccagc tgccgggctc ccgtttggcc
      541 agaagcaagt cacccctccg cctgcagtgg caccaggcct ctgggagctg actagcctgg
      601 ctgaattgct tctaaccctt ccaagtctga gcacagagag aagcctgggg aagaggcagc
      661 tgtgaaagag caagaatggt ccacctgccc cttacccaag ttttggacgg cctccatgcg
      721 tcctgccaga gagaagagag acttctaaga gtctctgaga aggggcctgc caacttcaac
      781 agccctggct cccttaggtc gctttttgga gaaagtgtca aatcttctgg aactggagtt
      841 actgatggtt gagagccacc ccgtggatgc tgggaatcaa acatgggacc ttcgcaagag
      901 caacaaatgc tccaaaacac cgagcctctt ccaagagagc gaactttgaa catcagtgcc
      961 ctccctgggc tgagcagcaa gggaagtcct gtgagcagca gtccagtgac tgtgtcctga
     1021 taagtgccct tgggatggag tagaaggtct aaaagtctga tagcctaggc ggggtgccac
     1081 ccacacctac cctcacccca gtagtgatgg cgcaggtggc gtcccgggaa cctgacaccc
     1141 aagatgaata aatgatgcgg actcaaccgc ccgcagccag aactctccgc ggccgctgcc
     1201 actaccaccg tcaccgcctg ccggtggcca ggggcagtca cctggtagct ctgtgcatca
     1261 gccccctctg ctctcaggac ctgtagcgga gcccgcggca aacaggagaa catggccggg
     1321 aggcagcgtg gctcggggcg gctctgggcg ctgggcggcg ccgcgctggg ggcttgcctg
     1381 gcgggtgtcg cctcgcagct ggtagagccc agcacggccc cgcccaagcc caagccgccc
     1441 ccactgacca aggagaccgt ggtgttctgg gacatgcgcc tgtggcatgt ggtgggcatc
     1501 ttttccctct tcgtgctgtc catcatcatc acgctgtgct gtgtgttcaa ctgccgtgta
     1561 ccgcggacac ggaaggagat cgaggctcgg tatctacagc gaaaagcagc caagatgtac
     1621 acagacaagc tggagaccgt gcctcccctc aacgaactca cagaaatccc tggagaggac
     1681 aagaagaaaa agaagaagga cagtgtggac accgtggcta tcaaggtaga ggaggacgag
     1741 aagaatgagg caaagaagaa aggagagaag tgagggcggc gtcctggaga tggcagccgg
     1801 ggctggcagg ccctgaagcg taagttcagg ccgggatcca ggcatcaaga ctccgagttc
     1861 atacatggac ggcagaggct gtggtccaag ggaaagccaa ggtcgtgggc attacctcac
     1921 ggcccaaaag atgtagggac aagactggac tctgttcatt tcacatggtc agtctgggca
     1981 cttctcacgg gccactgtcc ctctatagat atagagtggc ctcaaactcc tctccccatc
     2041 caggcaagct tctgtcccac ccttcttgcc aggggcagaa gtggctatga aggagtcagg
     2101 gattggtcga tgaggatggc aggattgaac agattgttca acaacacaga tggaggactg
     2161 gaaggggact tgtgacatgg gagattctct gacatagcta gatagccacc ccaaagagca
     2221 aggagattgc cccaagtttg acggtgatct gtccttggct tctagggtgt ccccattatc
     2281 aggagaatcc ctgatctggc aaatgccaag ctctgaaaac aaggtaacag cgtgacaggg
     2341 cggagaccac tgaggggctg gcaggaggcc tagggcctaa gggcttctgg ctcaggggtg
     2401 gggtctgaaa catagaagaa tgagttgcgt gggccgagtg agaaaacctg ggtctcctca
     2461 cgggaaccaa gaactactca agacgcagtg catggggtac ggactactgc ggttgccttt
     2521 tctctggcca ggactctgtc agaccaccag tctgccgaac acagtggtat gcaggtcctc
     2581 ttctgccatg tcccttact
//
LOCUS       NM_001191944            3882 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 18 (Adamts18), mRNA.
ACCESSION   NM_001191944 XM_574244
VERSION     NM_001191944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Xu,B., Zhang,J.E., Ye,L. and Yuan,C.W.
  TITLE     The progression of obstructive renal fibrosis in rats is regulated
            by ADAMTS18 gene methylation in the embryonic kidney through the
            AKT/Notch pathway
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23628 (2024)
   PUBMED   38229317
  REMARK    GeneRIF: The progression of obstructive renal fibrosis in rats is
            regulated by ADAMTS18 gene methylation in the embryonic kidney
            through the AKT/Notch pathway.
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Aldahmesh,M.A., Alshammari,M.J., Khan,A.O., Mohamed,J.Y.,
            Alhabib,F.A. and Alkuraya,F.S.
  TITLE     The syndrome of microcornea, myopic chorioretinal atrophy, and
            telecanthus (MMCAT) is caused by mutations in ADAMTS18
  JOURNAL   Hum Mutat 34 (9), 1195-1199 (2013)
   PUBMED   23818446
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Li,Z., Nardi,M.A., Li,Y.S., Zhang,W., Pan,R., Dang,S., Yee,H.,
            Quartermain,D., Jonas,S. and Karpatkin,S.
  TITLE     C-terminal ADAMTS-18 fragment induces oxidative platelet
            fragmentation, dissolves platelet aggregates, and protects against
            carotid artery occlusion and cerebral stroke
  JOURNAL   Blood 113 (24), 6051-6060 (2009)
   PUBMED   19218546
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jul 17, 2010 this sequence version replaced XM_574244.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000019.1  58748850-58748939   c
            91-181              JAXUCZ010000019.1  58748657-58748747   c
            182-498             JAXUCZ010000019.1  58745206-58745522   c
            499-781             JAXUCZ010000019.1  58680336-58680618   c
            782-975             JAXUCZ010000019.1  58678039-58678232   c
            976-1059            JAXUCZ010000019.1  58677636-58677719   c
            1060-1219           JAXUCZ010000019.1  58675761-58675920   c
            1220-1325           JAXUCZ010000019.1  58673692-58673797   c
            1326-1463           JAXUCZ010000019.1  58668883-58669020   c
            1464-1617           JAXUCZ010000019.1  58666010-58666163   c
            1618-1713           JAXUCZ010000019.1  58657109-58657204   c
            1714-1862           JAXUCZ010000019.1  58653591-58653739   c
            1863-2035           JAXUCZ010000019.1  58646796-58646968   c
            2036-2166           JAXUCZ010000019.1  58641942-58642072   c
            2167-2290           JAXUCZ010000019.1  58640603-58640726   c
            2291-2535           JAXUCZ010000019.1  58639996-58640240   c
            2536-2677           JAXUCZ010000019.1  58612980-58613121   c
            2678-2804           JAXUCZ010000019.1  58611836-58611962   c
            2805-3009           JAXUCZ010000019.1  58608315-58608519   c
            3010-3192           JAXUCZ010000019.1  58605644-58605826   c
            3193-3396           JAXUCZ010000019.1  58603892-58604095   c
            3397-3544           JAXUCZ010000019.1  58601925-58602072   c
            3545-3882           JAXUCZ010000019.1  58597745-58598082   c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3882
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 18"
                     /db_xref="GeneID:361412"
                     /db_xref="RGD:1560118"
     CDS             1..3660
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 18; A disintegrin
                     and metalloproteinase with thrombospondin motifs 18"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 precursor"
                     /protein_id="NP_001178873.1"
                     /db_xref="GeneID:361412"
                     /db_xref="RGD:1560118"
                     /translation="MECALLFLCALRAAGPGPPWGPAGLARLAKALQLCCLCCASVAV
                     ALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHNRKRRSAHGASSSVHYRFS
                     AFGQDLHLELKPSALLSSHFIVQVLGKDGASETREPAVVQQCLYQGFIRNDSLSSVAV
                     STCAGLSGLIRTRDNEFLISPLPQLLAQQHNYSLPAGHHPHVLYKRTAEKRVRRYQDY
                     PASQRTYPGHSPSHTPPASQSQETEYRHRRWQKQHFCGRRKKYAPKPPAEDAYLRFDE
                     YGGAGRPRRSARKSQKGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGT
                     IGSDINIVVVSLILLEDEPGGLLINHHADQSLNSFCQWQSALVGKNGKRHDHAILLTG
                     FDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGE
                     GNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYP
                     DKLPGQIYDADTQCKWQFGAKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTV
                     CGLSMWCRQGQCVRLGDLGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSNPKPQY
                     GGKYCPGSSRIYKLCNINPCHENSLDFRAQQCAEYNNKPFRGWLYRWRPYTKVEEEDR
                     CKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICEPVGCDHELGSKAVSDACG
                     VCKGDNSTCKFYKGLYLSQHKANEYYPVVTIPAGARSIEIQELELSSSYLAVRSLSQK
                     YYLTGGWNIDWPGDFTFAGTTFEYQRPFNRPERLYAPGPTNETLVFEILTQGKNPGIT
                     WKYALPKVMNVTQPAAKRHHHTWRTVQSDCSVTCGGGYISIKAICLRDQNTQVNSSFC
                     SVRTKPATEPKLCNAFSCPAYWLPGEWSTCSKSCAGGQQSRKIRCVQKKPFQKEEAVL
                     HSLCPVSTPTQVQVCNSHACPPEWSPGPWSQCSKTCGRGVRRREVLCTSPAAETLPES
                     LCSSSPKPEAQEGCVLGRCPKNNRLQWIASAWTECSATCGLGVRKREFKCMEKTLQGK
                     LMTFPERRCRNIKKPNLELEETCNRRACPVYSMAAGWYSSPWQQCTVTCGGGVQTRSV
                     HCMQQGRPSSSCLLHQKPPVLRACNTNFCPVPEKRDDPSCVDFFSWCRLVPQHGVCNH
                     KFYGKQCCRSCSRKS"
     sig_peptide     1..141
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    193..612
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    193..612
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    880..1485
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...; Region:
                     ZnMc_ADAMTS_like; cd04273"
                     /db_xref="CDD:239801"
     misc_feature    880..1485
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...; Region:
                     ZnMc_ADAMTS_like; cd04273"
                     /db_xref="CDD:239801"
     misc_feature    order(1309..1314,1321..1323,1339..1341)
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="active site"
                     /db_xref="CDD:239801"
     misc_feature    order(1309..1314,1321..1323,1339..1341)
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="active site"
                     /db_xref="CDD:239801"
     misc_feature    1534..1737
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAMTS cysteine-rich domain 2; Region: ADAMTS_CR_2;
                     pfam17771"
                     /db_xref="CDD:465496"
     misc_feature    1534..1737
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAMTS cysteine-rich domain 2; Region: ADAMTS_CR_2;
                     pfam17771"
                     /db_xref="CDD:465496"
     misc_feature    1777..1935
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1777..1935
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
     misc_feature    1945..2247
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAMTS cysteine-rich domain; Region: ADAMTS_CR_3;
                     pfam19236"
                     /db_xref="CDD:437068"
     misc_feature    1945..2247
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAMTS cysteine-rich domain; Region: ADAMTS_CR_3;
                     pfam19236"
                     /db_xref="CDD:437068"
     misc_feature    2251..2586
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAM-TS Spacer 1; Region: ADAMTS_spacer1;
                     pfam05986"
                     /db_xref="CDD:461796"
     misc_feature    2251..2586
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAM-TS Spacer 1; Region: ADAMTS_spacer1;
                     pfam05986"
                     /db_xref="CDD:461796"
     misc_feature    2650..2796
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2650..2796
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2806..2976
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2806..2976
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2986..3147
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    2986..3147
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3169..3348
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3169..3348
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3373..3513
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3373..3513
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="Thrombospondin type 1 domain; Region: TSP1_ADAMTS;
                     pfam19030"
                     /db_xref="CDD:465950"
     misc_feature    3556..3648
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="PLAC (protease and lacunin) domain; Region: PLAC;
                     pfam08686"
                     /db_xref="CDD:462560"
     misc_feature    3556..3648
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="PLAC (protease and lacunin) domain; Region: PLAC;
                     pfam08686"
                     /db_xref="CDD:462560"
     exon            1..90
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            91..181
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            182..498
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            499..781
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            782..975
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1059
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1219
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1325
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1463
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1617
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1713
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1862
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2035
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2166
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2290
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2535
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2677
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2804
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3009
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3192
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3396
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3544
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3882
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtgcg ccctcctgtt cctgtgcgcc ctccgggccg ccggtcctgg gccgccgtgg
       61 gggcccgcgg gactggcgcg tctggccaag gcgctccagc tgtgctgcct ctgctgtgct
      121 tcggtggccg tcgccttagc cagtgacagc ggcagcagcg gtggcagcgg attaaatgat
      181 gattacgtct ttgtcgtgcc agtagaagtg gactcgggcg ggtcatatat ttcgcacgac
      241 attttgcaca acaggaaaag gcgatcggca cacggtgcca gcagctccgt gcactaccgc
      301 ttttcagcat ttggacagga tctacactta gagcttaagc cctcggcgct tttgagcagt
      361 cactttatag tccaggtact tggaaaggat ggtgcttcag agactcggga gcctgcggtg
      421 gtacagcagt gtttgtatca gggatttatc agaaatgaca gcctgtcctc tgttgctgtg
      481 tctacgtgtg ccggcttgtc aggtctgata aggacacgag acaatgaatt cctcatctca
      541 ccgctacctc agctgctggc ccagcaacac aactacagct tgcctgcagg ccaccatcct
      601 cacgtcctgt acaaaaggac agcagagaag agggtcagga ggtatcaaga ctaccctgcc
      661 tcccagcgga catatcctgg tcactcccca agtcacaccc cccctgcctc ccagagccaa
      721 gagacagagt accgccatcg aaggtggcaa aagcagcatt tttgtggacg acgcaagaaa
      781 tatgccccca aacctcctgc agaagatgcc tatctacgtt ttgatgaata tggaggcgca
      841 ggacggccca gacgatcagc cagaaagtct caaaagggtc tcaacgtgga gaccctcgtg
      901 gtggcagatg caaagatggt ggagaagcac ggcaaggatg acgtcactac gtacatcctc
      961 acagtcatga acatggtttc tagcctgttc aaagatggga ccattggaag tgacataaac
     1021 attgtggttg tgagcctaat tctgttggaa gacgaacctg gaggattgct gatcaatcac
     1081 catgcagacc agtctctaaa tagcttctgt caatggcagt cagcccttgt gggaaagaac
     1141 ggcaagagac acgaccatgc catcctcctc acaggatttg acatttgttc ctggaagaac
     1201 gaaccgtgtg acaccctagg atttgcacct atcagtggga tgtgcagtaa ataccgaagc
     1261 tgtaccatca atgaagacac aggacttggc cttgccttca ccattgcaca tgagtcaggg
     1321 cacaactttg gcatggttca tgatggcgaa ggcaacccct gcaggaaggc ggaaggcaac
     1381 atcatgtccc ccacgctgac cggaaacaat ggggtgtttt catggtcctc ctgcagccgt
     1441 cagtatctaa agaaattcct cagtacacca caggctggct gtctggtgga tgagcccaag
     1501 caaacgggac agtataaata tccggacaaa ctcccaggac agatttatga tgccgacacg
     1561 cagtgtaagt ggcaatttgg agccaaagcc aagctgtgca gccttggggt tatgaaggac
     1621 atttgcaagt cgctctggtg ccaccgcgtg ggccacagat gtgaaaccaa gttcatgcct
     1681 gcagccgagg ggaccgtctg tggcttgagc atgtggtgtc ggcaaggcca atgtgtaagg
     1741 cttggagatc tcgggccccg gcccatccac ggccagtggt ctgcctggtc gaagtggtca
     1801 gaatgttctc gaacatgcgg tggaggagtc aagtaccagg agagacactg tagtaacccc
     1861 aagcctcagt atggtgggaa gtactgtcca ggatctagcc gcatctacaa gctgtgcaac
     1921 attaaccctt gtcatgagaa tagcttggat ttccgtgccc agcaatgtgc agagtataac
     1981 aacaagccct tccggggatg gttgtaccgt tggagaccct atacaaaagt tgaagaggaa
     2041 gatcgatgta aactctactg caaggctgag aactttgagt tttttttcgc catgtctggc
     2101 aaggtgaaag acgggacgcc ttgctcccca cacagaaatg atgtctgcat cgacgggatt
     2161 tgtgaacctg tgggatgcga ccatgaactt ggctctaagg cagtgtcaga tgcatgcggt
     2221 gtttgcaaag gcgataactc gacttgcaag ttttataaag gcctgtacct cagtcagcac
     2281 aaagccaacg agtattatcc tgtggtcact atccccgctg gggcccgaag cattgaaatt
     2341 caggagttgg agctttcttc cagctatctt gctgttcgaa gcctcagtca aaagtattac
     2401 ctcacagggg gctggaacat cgactggcct ggggacttca ccttcgccgg caccacattt
     2461 gaataccagc gtccctttaa ccgccctgaa cgactgtacg cgccaggacc cacaaatgag
     2521 acgctggtct ttgaaattct gacccaaggc aagaaccccg ggatcacttg gaagtacgca
     2581 cttcccaagg tcatgaatgt aactcagcca gcggccaaga gacaccacca cacctggcgc
     2641 acagtacagt ctgactgctc ggtcacctgc ggcggaggtt acataagcat caaggccatt
     2701 tgcttacgag atcaaaacac ccaagtcaat tcctcattct gcagtgtaag aaccaagcca
     2761 gcaacggaac ccaagctatg caatgctttc tcctgcccag cctattggtt gccaggtgag
     2821 tggagtacat gcagcaagtc ctgtgccggg ggccagcaga gccgcaagat ccggtgtgtg
     2881 cagaagaagc ccttccagaa agaggaggct gtgctgcatt ctctctgtcc agtgagcacg
     2941 cctacccagg ttcaagtctg caacagccat gcctgccctc cagagtggag ccccgggccc
     3001 tggtctcagt gttccaagac ctgtggccgg ggagtgagga gacgtgaggt cctctgtaca
     3061 agccctgcag ccgagacact ccccgagagc ctgtgttcca gcagccccaa acccgaggca
     3121 caggagggct gtgtgctggg acggtgcccc aagaacaaca gactgcagtg gatcgcctct
     3181 gcctggactg agtgttctgc aacctgtggc ttgggtgtga ggaagagaga attcaagtgc
     3241 atggagaaga ccctgcaggg aaagctgatg acgttcccag agcggagatg tcgcaacatt
     3301 aagaagccaa acctggaact ggaagaaacc tgcaaccgaa gggcttgccc agtatacagc
     3361 atggcggcag gctggtattc gtccccgtgg caacagtgca ctgtaacctg tgggggaggg
     3421 gtccagaccc gatctgtcca ctgcatgcag caaggccggc cttcctcaag ttgtctgctc
     3481 catcagaagc ctccggtgct aagagcctgt aataccaact tctgtccagt tcctgaaaag
     3541 agagatgatc cgtcgtgtgt ggatttcttc agctggtgtc gcctggtccc tcagcacgga
     3601 gtctgcaacc acaaatttta tggaaaacag tgctgtcgat catgctcaag gaagagctga
     3661 tctcagggtc tcctcatccc cctcagacca ggacctgacc cgtccatctc caggtcttca
     3721 tatcaagact acaaaccaca gaggaattgc cacggggttt aaaaaactgg acagatagcc
     3781 accggcctcc ttagttgagc cctggaaaca catggtactc tccaacactt gacagtgaga
     3841 cgcgatgaca aatctaactt aaaaggaaaa aaaaaaaaaa aa
//
LOCUS       NM_001437628            2287 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 6 (Chst6),
            transcript variant 2, mRNA.
ACCESSION   NM_001437628 XM_006255632
VERSION     NM_001437628.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Akama,T.O., Misra,A.K., Hindsgaul,O. and Fukuda,M.N.
  TITLE     Enzymatic synthesis in vitro of the disulfated disaccharide unit of
            corneal keratan sulfate
  JOURNAL   J Biol Chem 277 (45), 42505-42513 (2002)
   PUBMED   12218059
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Akama,T.O., Nakayama,J., Nishida,K., Hiraoka,N., Suzuki,M.,
            McAuliffe,J., Hindsgaul,O., Fukuda,M. and Fukuda,M.N.
  TITLE     Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal
            GlcNac 6-O-sulfotransferase both produce keratan sulfate
  JOURNAL   J Biol Chem 276 (19), 16271-16278 (2001)
   PUBMED   11278593
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   Bartes,A., Bhakta,S. and Hemmerich,S.
  TITLE     Sulfation of endothelial mucin by corneal keratan
            N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)
  JOURNAL   Biochem Biophys Res Commun 282 (4), 928-933 (2001)
   PUBMED   11352640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 7, 2025 this sequence version replaced XM_006255632.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212819.1, SRR26643298.76541.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000019.1  56790125-56790306   c
            183-415             JAXUCZ010000019.1  56773007-56773239   c
            416-2287            JAXUCZ010000019.1  56769975-56771846   c
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2287
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="carbohydrate sulfotransferase 6"
                     /db_xref="GeneID:307859"
                     /db_xref="RGD:1561144"
     exon            1..182
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /inference="alignment:Splign:2.1.0"
     exon            183..415
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    347..349
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="upstream in-frame stop codon"
     exon            416..2287
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1618
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="isoform 2 is encoded by transcript variant 2;
                     carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5;
                     carbohydrate sulfotransferase 5"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 5 isoform 2"
                     /protein_id="NP_001424557.1"
                     /db_xref="GeneID:307859"
                     /db_xref="RGD:1561144"
                     /translation="MRLPRFSSTVVLSLLIVQTGILVFLVSRQMPSSPAGRGEHVHVL
                     VLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWDALSQASAPALHMAVRDLIRSVFLC
                     DMDVFDAYLPWRRNISDLFQWAVSRALCSPPVCDAFARGNISSEEVCKPLCATRPFGL
                     AQEACSSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKAL
                     ARDNGIVLGTNGTWVEADPRLRVVSEVCRSHVRIAEVALHKPPPFLQDRYRLVRYEDL
                     ARDPLTVIRELYAFTGLGLTPQLQTWIYNITHGSGPGARREAFKTTSRDALSVSQAWR
                     HTLPFAKIRRVQELCAGALQLLGYRPVHSELEQRDLSLDLLLPRGMDSFKWASSTDKQ
                     PES"
     misc_feature    905..1501
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
     misc_feature    905..1501
                     /gene="Chst6"
                     /gene_synonym="Chst5; RGD1561144"
                     /note="Sulfotransferase domain; Region: Sulfotransfer_1;
                     cl21551"
                     /db_xref="CDD:473908"
ORIGIN      
        1 agacacggtc cgggttgggg aggatagagg agctccaggc caactggctg cttccttgct
       61 cggctcccgc cctggctccc gccggcggcc ccaggcaaag agccaccact cactgagctg
      121 ctcattgtat gcgccccggg cgggcagcgc agagcagcac agaagcgcag ccggcagcgc
      181 aggctcgagg aacctccagg tacctcccac gggtttgtga gcaacacaag ccagctctcc
      241 cagccctaga cagcagtgag tactcacggc aggggaaggg ccagcagcct gccatgggca
      301 cgcctctgct ctgtctctct gcttctccca cttcactggg ctcttctgaa acccatggct
      361 tccagagaac atcctcggtc tagaggacgt cctaacttca acactttctc cccaggctct
      421 agccagaggc atgcggctac cccgcttctc cagcactgta gtgctttcgc tcctgatagt
      481 gcagaccggc atcctggtct tcctggtctc ccggcaaatg ccatcatccc cagcaggccg
      541 tggggagcat gtgcatgtgc tggtgctgtc ctcctggcgc tcgggctcgt ctttcgtggg
      601 ccagctcttc agccaacacc cggatgtctt ctacctgatg gagccagctt ggcacgtgtg
      661 ggatgcgttg tcgcaggcca gtgcccccgc gctccacatg gccgtgcgcg acctgatccg
      721 ttcagtgttc ctatgcgaca tggacgtgtt cgatgcctac ctgccctggc gccgcaatat
      781 ctcggatctc ttccagtggg cagtgagccg ggcgttgtgc tcgcctccag tctgcgacgc
      841 cttcgctcgg ggcaacatta gcagcgagga ggtgtgtaag cctctgtgtg caacgcggcc
      901 cttcggcctg gctcaggaag cctgcagctc ctacagtcac gtagtgctca aggaggtgcg
      961 cttctttaac ctgcaggtgc tctaccccct gctcagcgac cctgcgctca acctgcgcat
     1021 cgtgcaccta gtacgcgacc cgcgggccgt gctacgttcc cgagagcaga cagccaaggc
     1081 gctggcacgg gacaatggca tcgtcctggg taccaacggc acatgggtgg aggcagaccc
     1141 ccggctgcgc gtggtcagcg aggtgtgccg cagccatgtg cgcatcgcag aggtagcatt
     1201 gcacaagccg ccgcctttct tgcaagatcg ctaccgcctg gtgcgctatg aagacctggc
     1261 ccgagacccg ctcaccgtaa tccgtgaact ctatgccttc actggtctgg gtctcacgcc
     1321 gcagctccag acttggattt acaacatcac ccatggctcg gggccaggcg cacgccgtga
     1381 ggccttcaag accacatcca gggatgcgct cagtgtatcc caggcttggc gccacacact
     1441 gccctttgcc aagattcgcc gggtccagga gctgtgcgcg ggtgcactgc agctgctcgg
     1501 ttaccggcct gtgcactcgg agcttgagca acgggacctc tctctggacc tcctgctgcc
     1561 acgaggcatg gacagtttca agtgggcgtc gtccacggat aagcaaccgg aatcttagaa
     1621 ttttagcgga gagagccagc tctgacatta gggtctattg gagtatgata aagggcttgg
     1681 agaactcaaa agcaagtgac cggaagtggg agtggtcttg ccctgtatca ggaaaggatg
     1741 gagtccaaat cccacatttc gttttgtcca gattatagtt ttcctttggg tcggtccttt
     1801 aggatttgga ttcccatcaa gtactgtcga tggaaagtga aagtgtccac ttcctgaggt
     1861 cacagaggca gccagacacc tactgaagca cttcctttct ctttgacttt ctcccccctt
     1921 tggtcatacc atggtgtccc aggtctggtc aggagtggag gaagggcgct gctatggggt
     1981 ggctcctaaa atttgtgcac ctgcccctca ttggctcgcc ctgatgtctg cccatctctg
     2041 tgccctagcc cccctggaca gttatgtgca cggtcaagga ggaatcggag aggatgcctc
     2101 tgtagtttcc ccttagattc tctgcctgac cttctaggag ggagccttgg cgtatacccc
     2161 atgcctgagg acgacggctt tttaatgaac ctttggtttg tcctgagatg aaagatccta
     2221 attatggaaa taaacatcat aaatacgctg cgtgatccag attagagcct atcgcatgtg
     2281 aaaagca
//
LOCUS       NM_001437649            6552 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus BICRA like chromatin remodeling complex
            associated protein (Bicral), transcript variant 1, mRNA.
ACCESSION   NM_001437649 XM_039083177
VERSION     NM_001437649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6552)
  AUTHORS   Alpsoy,A. and Dykhuizen,E.C.
  TITLE     Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its
            paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes
  JOURNAL   J Biol Chem 293 (11), 3892-3903 (2018)
   PUBMED   29374058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 7, 2025 this sequence version replaced XM_039083177.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643429.33054.1, SRR26643292.36732.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000009.1  21597886-21597929
            45-140              JAXUCZ010000009.1  21619900-21619995
            141-421             JAXUCZ010000009.1  21626087-21626367
            422-467             JAXUCZ010000009.1  21652977-21653022
            468-516             JAXUCZ010000009.1  21653487-21653535
            517-585             JAXUCZ010000009.1  21653615-21653683
            586-2259            JAXUCZ010000009.1  21658071-21659744
            2260-2377           JAXUCZ010000009.1  21669210-21669327
            2378-2478           JAXUCZ010000009.1  21670806-21670906
            2479-2537           JAXUCZ010000009.1  21672867-21672925
            2538-2683           JAXUCZ010000009.1  21673963-21674108
            2684-2778           JAXUCZ010000009.1  21675121-21675215
            2779-2881           JAXUCZ010000009.1  21675901-21676003
            2882-6552           JAXUCZ010000009.1  21679315-21682985
FEATURES             Location/Qualifiers
     source          1..6552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..6552
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="BICRA like chromatin remodeling complex associated
                     protein"
                     /db_xref="GeneID:301235"
                     /db_xref="RGD:1305680"
     exon            1..44
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            45..140
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            141..421
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    160..162
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="upstream in-frame stop codon"
     exon            422..467
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..3663
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="GLTSCR1-like; BRD4 interacting chromatin remodeling
                     complex associated protein like; BRD4 interacting
                     chromatin remodelling complex associated protein like"
                     /codon_start=1
                     /product="BRD4-interacting chromatin-remodeling
                     complex-associated protein-like"
                     /protein_id="NP_001424578.1"
                     /db_xref="GeneID:301235"
                     /db_xref="RGD:1305680"
                     /translation="MDDDDDSCLLDLIGDPQALNYFLHGPSSKSSGDDVTNAGYSAAN
                     SNSIFANSTNADPKSSLKGVSNQLGEGPSDGLPLASSLQFLEDELESSPLPDLSEDQP
                     FDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSG
                     QTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLPNSSQISGSGQIQLIGS
                     FGNQPSMMTINNLDGSQIILKGSGQQAPSSVSGGLLVHRQTPNGNSLFGNPTSSPGAQ
                     PVTVPFNSTNFQASLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQSTYNVNSLGLQ
                     QHHVQQGISFASASSPQGSVVGPHMSVNIVNQQNARKPVTSQAVSSAGGSIVIHSPMG
                     QPHTPQSQFLIPTSLSVSSNSVHHVQTINGQLVQTQPSQLISGQVASEHVMLNRNSSN
                     MLRTNQPYAGQMLNNQSAAVQLVSGQTFATSGSPVIVNHASPQIVGGQMPLQQASPTV
                     LHLSPGQSSVSQGRPGFATMASVSSMSGPARFPAVSSASTAHPTLGPAVQSGASGSNF
                     TGDQLTQANRTPVPVSVSHRLPVSASKSPSTLSSTPGTQQQFFCQAPKKCLNQTAPIP
                     TPIPTSKTTDSLRQPQIPGLLSTALPGQDCGSKIMPAPLGTTQPQQENSVGSSPSQTA
                     VQVDSHSGQKRPAAKQLTKGAFILQQLQRDQAHAVTPDKSQFRSLTDTVQRLLSYHVC
                     QGSMPTEEDLSKVDSEFEEVATQLLKRTHAMLNKYRSLLLEDAMRINPSAEMVMIDRM
                     FNQEERASLSRDKRLALVDPEGFQADFCCSFKLDEAAPETPLDRSDQHRSKTSSLHQV
                     PRAQSRDRAKPGVAEATNHDQFHLVPNHIVVSAEGNISKKSEGHSRTLKFDKGVLGQY
                     RGPPEDKGGRRDPAKASGCSPGPEGHRKTLPRPDHGSESKLPGILASSHMEMPCLDSF
                     QDKALRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLEKTFKNILELKNAGRPQNDPAAS
                     GAVDLDFPSFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC"
     misc_feature    1918..>2436
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    1918..>2436
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:460830"
     misc_feature    2560..2862
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Conserved region of unknown function on GLTSCR
                     protein; Region: GLTSCR1; pfam15249"
                     /db_xref="CDD:464589"
     misc_feature    2560..2862
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /note="Conserved region of unknown function on GLTSCR
                     protein; Region: GLTSCR1; pfam15249"
                     /db_xref="CDD:464589"
     exon            468..516
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            517..585
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            586..2259
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2377
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2478
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2537
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2683
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2778
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2881
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..6552
                     /gene="Bicral"
                     /gene_synonym="Gltscr1l; RGD1305680"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttccttc ttaaaggggc aggacttata tccgggattg tgggcagtct actgcctgga
       61 tgatcacgtg actgacttct tgccttgtac catcccccgt ccttctgggt gcctggagtg
      121 gaaggatctg cctaagacag gcaagaccga agtttgaggt agacgagcag gcgagccgtt
      181 tgcccgggcg cagagcatga aggccgggcg ggcgcgggga gcgggcgccc gccgcccggc
      241 gcgggggtga gcgagagaga gagcggagcg cgtgtggccg gcgccgctcg gcctggagct
      301 cccgcgcccg cgccccgcgc cccgcgcccg ccgccgccgc cgccgccgcc gccgccgccg
      361 ccgccgcccc tggtgcgatg gcgcagaaac cccgttgaca aggcactgct ttttcatgac
      421 gttgtcatgg atgatgacga tgactcctgt ctcctcgatc ttattggaga cccacaagca
      481 ttgaactatt ttctgcacgg acctagcagt aaatcgagcg gcgatgacgt gacgaacgca
      541 gggtattctg cagccaattc taattcaatt ttcgccaact ccacgaacgc tgaccctaag
      601 tcatccctca aaggtgtaag taaccagctc ggagaagggc ccagtgacgg gctgccgctt
      661 gcaagcagcc ttcagtttct tgaagatgaa cttgagtctt ctcctctccc tgatctcagt
      721 gaggaccaac cctttgacat tcttcagaaa tccttgcagg aggctaatat cactgaacag
      781 acgctggcag aagaggcata tctggatgcc agtataggct cgagccaaca gtttgcacaa
      841 gcccagcttc atccttcttc atcagcatcc tttactcagg cttctaatgt ttctaattac
      901 tcaggtcaga cactgcagcc tatcggggtg actcacgtgc ctgtcggagc atcgtttgca
      961 agcaatacag tgggtgtaca gcatggcttt atgcaacacg tggggatcag tgttcccagc
     1021 cagcatttgc ccaatagcag ccagatcagt ggctccggtc agattcagtt aatcgggtcc
     1081 tttggtaatc agccttccat gatgactatt aataacctag atggctctca aatcatattg
     1141 aaaggcagtg ggcagcaagc cccgtccagt gtgagtgggg ggcttctggt tcacagacag
     1201 actcctaacg gcaactcttt gtttgggaac cccacttcca gccccggagc acagcctgtc
     1261 accgtcccat ttaacagcac aaattttcaa gcatctctac ctgtgcataa catcattatt
     1321 caaaggggtc tcgcaccaaa ttcaaataaa gtcccaatta atatccagcc aaagccgatc
     1381 cagatgggtc agcagagtac atacaatgtg aacagccttg gactccagca gcaccacgtc
     1441 cagcaaggga tctccttcgc ctctgcaagc tcgccccagg gctccgtggt tggtccacac
     1501 atgtctgtga acattgtcaa ccaacagaac gcgaggaagc ctgtcacctc acaggcggtg
     1561 agcagcgcag ggggcagcat tgttattcac tcccccatgg gccagcctca cacaccccaa
     1621 agtcagttcc ttatacccac aagcctttct gtcagctcca actcggtcca ccatgtccag
     1681 actataaatg ggcaacttgt tcagactcag ccctcccagc tcatctctgg ccaagtggcc
     1741 tcagagcatg tcatgttgaa taggaattct tctaacatgc tcaggaccaa ccaaccatat
     1801 gccggacaga tgctcaacaa ccagagtgcc gctgtccagc tggtgtctgg gcagactttt
     1861 gccacctctg gaagcccagt gatcgtcaac catgcctctc ctcagatcgt gggaggacag
     1921 atgcccttgc agcaggcctc accaactgtg ctacacctgt cgcctgggca gagcagtgtt
     1981 tcccaaggaa ggccaggctt cgccaccatg gcctcggtga gcagcatgtc aggacctgct
     2041 cggttccccg ccgtcagctc agctagtact gcccacccta ctcttgggcc tgcagtacag
     2101 tctggggcat caggatcaaa ctttacggga gaccagctga cacaggcaaa cagaactccg
     2161 gtacccgtca gtgtgtccca ccgtcttcca gtctctgctt ccaaatctcc cagcaccttg
     2221 agcagcaccc cggggactca gcagcagttc ttctgtcagg ctccgaagaa gtgtttgaac
     2281 cagaccgccc ccattcccac ccccattccc acgtccaaga ccacagacag cctgcggcaa
     2341 ccacagatcc ctgggctctt gagcacagca ctgccaggac aggattgtgg aagcaaaatt
     2401 atgccagcac ccttggggac cacacagcca cagcaggaaa actcagttgg atcttccccg
     2461 agccagacag ccgtgcaggt ggacagtcat tcaggacaga agaggcctgc tgccaaacag
     2521 ctgactaaag gagctttcat cctccagcag ttacagaggg accaagccca tgctgtgaca
     2581 cccgacaaaa gccagttccg atcactgact gacaccgtgc agagactgct ctcctaccac
     2641 gtgtgccaag gctccatgcc cacggaggaa gacctgagca aagtggacag tgaatttgaa
     2701 gaagtcgcca ctcagctcct caaaaggacc cacgctatgc tgaacaaata cagatccctg
     2761 ctcctcgaag acgccatgag gatcaacccc tctgcagaga tggtgatgat tgataggatg
     2821 ttcaaccagg aggaaagagc ttccctgtca cgggacaagc gtctggcgct cgtagatcct
     2881 gagggttttc aggccgattt ctgttgttcc tttaaacttg acgaagctgc acctgagaca
     2941 ccgcttgaca ggagtgacca gcatcgcagc aaaaccagct cgctccatca ggtgcccagg
     3001 gcccaaagca gagaccgagc caagccaggc gtggcagaag caacgaatca tgaccagttt
     3061 catctagtgc ctaaccacat agtggtctct gcagagggaa acatttctaa aaagtcagaa
     3121 ggccacagta gaacactgaa atttgacaaa ggggtcttag gccaataccg gggtccgcct
     3181 gaggacaagg gcggccggag ggaccctgcc aaggccagcg ggtgctctcc aggccctgaa
     3241 ggccaccgca aaactttgcc caggccagac catggctctg agagcaagct cccgggtatc
     3301 ctggccagct cgcacatgga gatgccgtgc ctcgactcct tccaggacaa agccctgagg
     3361 aattccccaa agaatgaggt tttacacaca gacatcatga aagggtcggg tgaaccccag
     3421 ccagatctcc agctcaccaa gagcctagag aaaaccttta agaacatcct ggaactcaag
     3481 aatgcggggc ggccgcagaa cgacccagcg gccagcggcg cggtggacct ggacttcccc
     3541 agcttttctc caatggcttc gcaggaaaac tgcctggaaa agttcatccc ggaccacagc
     3601 gaaggcgttg tagaaacgga ctccatttta gaagcagctg taaatagtat cctagagtgt
     3661 taatagcagc cgtcctcccc cagaccctgc cctggaccag ttacattctc tcccagcaaa
     3721 gcaaatggaa acgtctcctg tccccagcct gcttggtcct ccgtcacagg ttatctttct
     3781 aatctccacc ctgttctttt gaagagcaat acatgtcttc gtggctgcag agagaccctc
     3841 agtaaacccc cctctctaga aagcagtccg ataggccctc cacatttcaa gtgtcatgga
     3901 agttttatgg ccattgttgg ttaatttgtt ttgtggtttg tttcttagca ctgtcactcg
     3961 agaccacagt acacttggcc ctgggtaaca ttttgacaat cataagtcat ttcaaaagaa
     4021 cagacttatt aaagaaaaat caaacaggac tgatagaagc cactttttta aagactctct
     4081 cactgcagct ccaaagtagt ggtttgcttt tgttctgttt tgggggagag ggtatttgcg
     4141 tagggaagac cccatgactc tcctccatgc tcggccctct gagcagtgac agccagtgct
     4201 ctgcctggaa ccccacaggc ctggccttag acgccagtag cacagcgcag agcaccctca
     4261 gactgccagt gctgtgtgac gctgctgaag caaagccttt tgggtttgtt gttttttttt
     4321 tttttttaag catatttatg ttgaattctg tctgccaatg ttctgttctt aaccccaggt
     4381 gtacgccttg aaattctcac gagctcagta gggaacaatg ggagccagtt ctaaggcagc
     4441 aagctgggga ggctgctgga gcccccaggg tcttggtgcg tgcagcttaa agagttttgc
     4501 gttttataac cgggtaaagg caacgtaacc tatgttcttt agtgttgctg actccgttcc
     4561 atttagcctc tgtgtctcct ctccctcagc ccacagccaa ggatcaaaag gctttcaact
     4621 tgaaaatcac gctgtgctct ctcagttgac gcttttgaag ggttcgctgg cctcgtttgt
     4681 gagaatagta gtcagcagtg tgtcatttat tcccaaacac agtaaaccaa aggtcacaac
     4741 cagcaggcca ctaaaggaag gaactgaggc aggagacggg catgtcctgg ccccgcctcg
     4801 ccgtgggtgc tcctcgctca cccgtggagc cttcctcttt tttatttatg ttctttgcgg
     4861 ggagcgttcc ctgttttccg ctcctgtggg cctgtaccag gcatgatgct tctgttgcta
     4921 ctggctctct tcctgccgta gtaacaggtc atggtgctgc tgtttgctgc ctccccacca
     4981 cctccacccc agccgtcagc ggggatcgga ggtcgttttg gttactgtga gggctcgttc
     5041 cctccggcca tccctctggc tgtgtaaatg tacccgttga tttctgcttc gtcatccccc
     5101 aacgcagttg tcccttcggt catcatgtgg agtgtttctt ttccagattg gcctgcagtg
     5161 gaaaggaagg cttttgattt tgactttgat ctttttttca aataacacag cagcaatcta
     5221 ggcatgttgg catacacctg taatcccagc agtcaggtga ctgaagcagg agtcacaggt
     5281 tcaaggccaa acaagaaaaa aagctgagaa atagcagagt gtgtggaccc tttctacccc
     5341 tgtgtccact acatagacaa actctgcgag acagacagac agcctttgag agcaatgtac
     5401 cttctcccac ccacaaccca gccaaccgaa acagaaaact ctgggctgtc ttagagttgc
     5461 ccttttcttc cttctctgtg ccaatatcca agttgctgac ttccttcctg tattgtaaca
     5521 cattagaaag atgagttatg tgccagttag gactctgtct gggcttccct gggttaccag
     5581 cctgccctgc tctctctggc gtcacaggct cttctcatag cctcatgacc gcctgcacac
     5641 ggctagtgat gaattacttt aattattgca aatcagtgga attcttaaga agtctcgtgt
     5701 atattcctta cctcttccct cccgctccag ccccagcttt ctttcctgtc tgtcaaatca
     5761 cagggcttct catccctgac attggtccca cacaccgaga gcctaccgta ccaaaatgaa
     5821 acttgtaaat ttttgtgtcc ttgtatgtaa gtttactttc tatggaggaa agactctaga
     5881 taatgacaaa tgaagattac aaagtgtatt ttactcctgt gatcaggtta caccacatgg
     5941 gtcataactc actcacgagc ccccgctggt gaagggaaat gctctgcctc agtggccaac
     6001 ggttggtggt tcagggtcat tagtcagttg agttttagaa cgcgtgctca gtaacaaaaa
     6061 tcatttttcc ttccctttgt ttttaatctg tttgttgttg tggaaaagta tgaatttgtt
     6121 attacgcatt gattttctgt gtccttaagt actgcctaaa gatgaagcaa attttgaagt
     6181 ggcaattact ataaggaaat cctttagctc tggagaattt agtgggctct gttagattgg
     6241 gaggcctcac aggctggccg gctccgagga cggtcactca ctgtcagtgt ggtgtgggct
     6301 ttatttgctt aaataccttc atttgtatag tatgtctcac ttgaaattgc tttgtataca
     6361 ttttgtaaaa atatttataa aatgttttgt aaaaaaaaag tataagaaat tgcagtttat
     6421 tttgttatgt tggataaata ctgttaaacc agtcagtacc tatattgtta atccatggtt
     6481 aggaaatgtt cagttggaga ttacagaatg aaacaaccat tgcaatacag ccaaagattt
     6541 gggaaaatgt aa
//
LOCUS       NM_001106885            3178 bp    mRNA    linear   ROD 09-APR-2025
DEFINITION  Rattus norvegicus triggering receptor expressed on myeloid cells 1
            (Trem1), mRNA.
ACCESSION   NM_001106885 XM_001063859 XM_039083174 XM_217336
VERSION     NM_001106885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Sun,X.G., Zhang,M.M., Liu,S.Y., Chu,X.H., Xue,G.Q., Zhang,B.C.,
            Zhu,J.B., Godje Godje,I.S., Zhu,L.J., Hu,H.Y., Hai-Wang, Shen,Y.J.
            and Wang,G.Q.
  TITLE     Role of TREM-1 in the development of early brain injury after
            subarachnoid hemorrhage
  JOURNAL   Exp Neurol 341, 113692 (2021)
   PUBMED   33727099
  REMARK    GeneRIF: Role of TREM-1 in the development of early brain injury
            after subarachnoid hemorrhage.
REFERENCE   2  (bases 1 to 3178)
  AUTHORS   Liang,Y.B., Song,P.P., Zhu,Y.H., Xu,J.M., Zhu,P.Z., Liu,R.R. and
            Zhang,Y.S.
  TITLE     TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal
            injury by inhibiting oxidative stress and pyroptosis
  JOURNAL   Biochem Biophys Res Commun 529 (3), 554-561 (2020)
   PUBMED   32736673
  REMARK    Erratum:[Biochem Biophys Res Commun. 2023 Oct 1;675:184-186. doi:
            10.1016/j.bbrc.2023.07.016. PMID: 37516577]
REFERENCE   3  (bases 1 to 3178)
  AUTHORS   Fang,K., Li,H.R., Chen,X.X., Gao,X.R., Huang,L.L., Du,A.Q.,
            Jiang,C., Li,H. and Ge,J.F.
  TITLE     Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats
            via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in
            the Hippocampus and PFC
  JOURNAL   Front Pharmacol 10, 1544 (2020)
   PUBMED   32009956
  REMARK    Erratum:[Front Pharmacol. 2020 Apr 15;11:518. doi:
            10.3389/fphar.2020.00518. PMID: 32351394]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3178)
  AUTHORS   Gorlier,C., Sellam,J., Laurans,L., Simon,T., Giurgea,I.,
            Bastard,J.P., Fellahi,S., Deshayes,S., Grateau,G., Ait Oufella,H.
            and Georgin-Lavialle,S.
  TITLE     In familial Mediterranean fever, soluble TREM-1 plasma level is
            higher in case of amyloidosis
  JOURNAL   Innate Immun 25 (8), 487-490 (2019)
   PUBMED   31474164
REFERENCE   5  (bases 1 to 3178)
  AUTHORS   Zhu,H., Li,W., Wang,Z., Chen,J., Ding,M. and Han,L.
  TITLE     TREM-1 deficiency attenuates the inflammatory responses in
            LPS-induced murine endometritis
  JOURNAL   Microb Biotechnol 12 (6), 1337-1345 (2019)
   PUBMED   31365951
REFERENCE   6  (bases 1 to 3178)
  AUTHORS   Gibot,S., Massin,F., Marcou,M., Taylor,V., Stidwill,R., Wilson,P.,
            Singer,M. and Bellingan,G.
  TITLE     TREM-1 promotes survival during septic shock in mice
  JOURNAL   Eur J Immunol 37 (2), 456-466 (2007)
   PUBMED   17230441
REFERENCE   7  (bases 1 to 3178)
  AUTHORS   Gibot,S., Alauzet,C., Massin,F., Sennoune,N., Faure,G.C.,
            Bene,M.C., Lozniewski,A., Bollaert,P.E. and Levy,B.
  TITLE     Modulation of the triggering receptor expressed on myeloid cells-1
            pathway during pneumonia in rats
  JOURNAL   J Infect Dis 194 (7), 975-983 (2006)
   PUBMED   16960786
REFERENCE   8  (bases 1 to 3178)
  AUTHORS   Determann,R.M., Weisfelt,M., de Gans,J., van der Ende,A.,
            Schultz,M.J. and van de Beek,D.
  TITLE     Soluble triggering receptor expressed on myeloid cells 1: a
            biomarker for bacterial meningitis
  JOURNAL   Intensive Care Med 32 (8), 1243-1247 (2006)
   PUBMED   16786330
REFERENCE   9  (bases 1 to 3178)
  AUTHORS   Knapp,S., Gibot,S., de Vos,A., Versteeg,H.H., Colonna,M. and van
            der Poll,T.
  TITLE     Cutting edge: expression patterns of surface and soluble triggering
            receptor expressed on myeloid cells-1 in human endotoxemia
  JOURNAL   J Immunol 173 (12), 7131-7134 (2004)
   PUBMED   15585833
REFERENCE   10 (bases 1 to 3178)
  AUTHORS   Bouchon,A., Hernandez-Munain,C., Cella,M. and Colonna,M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Apr 7, 2025 this sequence version replaced
            XM_039083174.2, NM_001106885.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.31735.1,
                                           SRR26643284.12054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000009.1  20276721-20276798   c
            79-435              JAXUCZ010000009.1  20272113-20272469   c
            436-607             JAXUCZ010000009.1  20267799-20267970   c
            608-3178            JAXUCZ010000009.1  20259227-20261797   c
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..3178
                     /gene="Trem1"
                     /note="triggering receptor expressed on myeloid cells 1"
                     /db_xref="GeneID:301229"
                     /db_xref="RGD:1309467"
     exon            1..78
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Trem1"
                     /note="upstream in-frame stop codon"
     CDS             30..710
                     /gene="Trem1"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 1
                     precursor"
                     /protein_id="NP_001100355.2"
                     /db_xref="GeneID:301229"
                     /db_xref="RGD:1309467"
                     /translation="MRKAGLWGLLLVFFVSEVKAAIVPEEERYDLVEGQTLTVNCPFN
                     IMKYARSRKAWQRLSAGKEPLTLVVTERSSTTSSEVRVGKYTLKDDPTEAMLFVQMTD
                     LQVTDSGLYRCVIYHPPNDPVLLFHPVRLVVTKGSSGVSVPDIIPTTKPTEVPVLITT
                     KHSTPTRSLPKSTAVVSSPDPGVTINNGTDPTSVSTYNVVVPVVCGLLIKTLIFFVLF
                     VVTKRSFG"
     sig_peptide     30..89
                     /gene="Trem1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    99..425
                     /gene="Trem1"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    99..425
                     /gene="Trem1"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    138..152
                     /gene="Trem1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    138..152
                     /gene="Trem1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    183..197
                     /gene="Trem1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    183..197
                     /gene="Trem1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    315..329
                     /gene="Trem1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    315..329
                     /gene="Trem1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    357..374
                     /gene="Trem1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    357..374
                     /gene="Trem1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    405..416
                     /gene="Trem1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    405..416
                     /gene="Trem1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            79..435
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..607
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..3178
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaagccg tcagggctga gctcgaagga tgaggaaggc tgggctctgg ggactcctgt
       61 tggtgttctt tgtctcagaa gtcaaagctg ccattgtccc agaggaagaa aggtatgatc
      121 tagttgaggg ccagaccttg acagtgaact gtcccttcaa catcatgaag tatgccagaa
      181 gcaggaaggc ttggcagagg ctatcagctg ggaaggaacc cttgaccctg gtggtcacag
      241 agaggtcctc tacaacatcc agtgaagtcc gtgtggggaa gtacaccctg aaagatgacc
      301 ctaccgaggc catgttattt gttcaaatga ctgaccttca agtgacagac tctggattat
      361 atcgttgtgt gatttaccat cctccgaacg accctgttct gctcttccat cccgtccgcc
      421 tggtggtgac caagggttct tcaggtgtgt ccgttcctga catcattcct accacaaagc
      481 cgactgaggt tcccgtcctc attaccacaa aacactcaac tccaacccga tccctaccca
      541 agtccactgc tgttgtttcc tctcctgatc ctggagtcac catcaacaat gggacagatc
      601 ctacgagtgt ctccacatac aatgttgttg ttcccgtggt ctgtgggctc ctcatcaaaa
      661 ctctgatctt cttcgtctta ttcgttgtca caaagaggtc atttggatga cagatcttga
      721 agctacacaa tagtgacctt cagccatgtc tatctcacag aaggagctga catggggggg
      781 ggtatagagg aactgtgaca cgaattgagc ctgtaatcat aggtgacatc taaggctcag
      841 gatgtcccca cctggtcctg cccaccctcc tcatctcatc catcatttag ggaacatgtt
      901 ctgcaccctc aggaaagagg aaccaattcc tagaacactc tggtctttcc cccttaatag
      961 gtgggtttgt ctgaaataaa gacagagcaa agtacttctc cctgtctcct tttggggcag
     1021 tcatgaagat taaggtttcc atgctatccc catcccttgt ccttcccctg gaccgtacaa
     1081 ttctagccac cttggcaggt cccttgctcg tgaagcagcc tgctctccca cctctggggc
     1141 cttctgctct gggagtcaga cactcagatt tctgccttca cctgtgctcc tcggaacact
     1201 cccaaccatg gatcaagaag acaagatccc accttgacaa taatgcaact gggagagagg
     1261 aatcaagata aactgggaaa ctgctgtttc ctgggaaaca cctagagaag cagatggcat
     1321 ctgtaggttt ggatcagtac agcacatcaa catgctgtgt tcattttatc attgactcct
     1381 cagtgcatcc catgagcatc aaggagtgtg tgagcagagt gaggccgcag gagtgaggcc
     1441 atcacctctt gtcaagaatg aaatgtagag agctcccttg gagagacagg gaagtggagg
     1501 ctccaaaggc agggggatgg agagccaggt tctgctctag ctgaatgcct ttttgcctgg
     1561 actgaggcag gggccagcat gacaagggtc ccaacccaag ctgtccccct gtgtgcctct
     1621 gcctcccacc caccttcctt cacctctcag tctcctccca ggtactctat gactccagtg
     1681 ctttctctgg gacatatcag cactttcttg ttcccacctc tttgggctct acagacaaag
     1741 tggccccatg gggcatgggg ggaggatctt acatgagctc attctatgtc agcaatggct
     1801 ggagccaact tcatcccaag gttcccaaga gcaaacacat caccacatag catccagctc
     1861 atgtgatctc cagtggtgct ctgggacaac atttgaagta ctgatacaga cgctgttcac
     1921 gttgctatgt ttgctttctg actggagagc ggagtagagg tttattgccc agtgggtaaa
     1981 atgcttcttg agaaagcctg gagaccagag ttcaagctat aagagcaatg taaaagaagc
     2041 tggttagggt gagcctgcct attatctcag ccctggggaa gctgaaacag ccagttccct
     2101 gggacttggg gatcagttag agaacatctt ctggtcagtg agagaccctg tgtcaagaag
     2161 aacaaaacaa aaacaaggat aacagcacac acacacacag agacgcagaa gcacatacac
     2221 acttacacac ttacacacac acacttacac acacacttac acacacacat acacacttac
     2281 acttgccaca cccactccag tagagtctgt atgacatgaa gctcttgtgc ttcgtttcta
     2341 tccagaacag aggcctgtgc ctggaatggc ttggcctcct ggaggtccct ggcagtctcc
     2401 ctacaaacag atgatgacta gggtctgtgc ttgcagtgga ggtgccttct gtgttttagc
     2461 cttcgtgatc ttagcaactt taagcctgtc aacaatatct gattttaaga atatagcagt
     2521 gtgggaagat ggtcatgtac ctttagatgt ctcaggaact gaaagttcag agatggaaac
     2581 atctcacacc atcatgatcc tgataaactc aacggctgca atgaatacaa ctgctgcacc
     2641 cattagttcc cagcaaatag gagagaaatt aattacagtt actaacaaca tggctgttcc
     2701 agaaaagcct ttcccccctt ttgggaaagt tttgtttcgc atgattcaaa ttagtaatga
     2761 ttcttctagg aagatcatag acaagttcca acaagttgga caaacttatc aagagttaac
     2821 tagaagaaaa agagaagcta acattgagca agaagtgaaa gaaattataa aatggttaca
     2881 aaagtttcca tattattctg aggggccata aatatagagt ttaaacttta ttatgacaaa
     2941 gataaacgat ggatgcatgc ctggtgccca caaatctggc agtatagctg cagttttttt
     3001 aaactattgt ttgcagctga gaactgtttc ctagactgta tgtttagctt tcctctttgc
     3061 aagggacatt ggtgtggtaa tgaataagag ctggatgact gccaattatg atgtacctgt
     3121 tgtaactgct taaacatacg ccaagaagta aagcttattg cagcagtgca cacctcaa
//
LOCUS       NM_001437800            7892 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 17 (Rgs17),
            transcript variant 2, mRNA.
ACCESSION   NM_001437800 XM_006227855
VERSION     NM_001437800.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7892)
  AUTHORS   Dhukhwa,A., Al Aameri,R.F.H., Sheth,S., Mukherjea,D., Rybak,L. and
            Ramkumar,V.
  TITLE     Regulator of G protein signaling 17 represents a novel target for
            treating cisplatin induced hearing loss
  JOURNAL   Sci Rep 11 (1), 8116 (2021)
   PUBMED   33854102
  REMARK    GeneRIF: Regulator of G protein signaling 17 represents a novel
            target for treating cisplatin induced hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7892)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   3  (bases 1 to 7892)
  AUTHORS   Sokolov,E., Iannitti,D.A., Schrum,L.W. and McKillop,I.H.
  TITLE     Altered expression and function of regulator of G-protein
            signaling-17 (RGS17) in hepatocellular carcinoma
  JOURNAL   Cell Signal 23 (10), 1603-1610 (2011)
   PUBMED   21620966
  REMARK    GeneRIF: RGS17 is differentially expressed in hepatocellular
            carcinoma cells and plays a central role in regulating transformed
            hepatocyte tumorgenicity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006227855.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.716.1,
                                           SRR26360176.2074377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  44729394-44729642   c
            250-393             JAXUCZ010000001.1  44672850-44672993   c
            394-483             JAXUCZ010000001.1  44652184-44652273   c
            484-718             JAXUCZ010000001.1  44649951-44650185   c
            719-7892            JAXUCZ010000001.1  44627583-44634756   c
FEATURES             Location/Qualifiers
     source          1..7892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..7892
                     /gene="Rgs17"
                     /note="regulator of G-protein signaling 17"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
     exon            1..249
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    47..49
                     /gene="Rgs17"
                     /note="upstream in-frame stop codon"
     exon            250..393
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..907
                     /gene="Rgs17"
                     /codon_start=1
                     /product="regulator of G-protein signaling 17"
                     /protein_id="NP_001424729.1"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
                     /translation="MRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVR
                     NEERGDSSGRPPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKAPAGRNLFREFL
                     RTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN
                     RNLLEPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTASSTSES"
     misc_feature    395..865
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     misc_feature    395..865
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     exon            394..483
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            484..718
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            719..7892
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagaggg ggcggagggg acgcccgccg cctgtgctgt ggctggtgaa gcagtgaggt
       61 gcaagggtct cggcgggcag cacctcctcg cggcttcgtg aagttgaatc ccgcgtggtc
      121 cgcttcaggg ctcggtccac tcgcgtcccc aggctctgta gaggggctgg accgctctcc
      181 tgccgggtca cggctttggg tgtccctgct cccgggagga gaaatctcag caccttcagg
      241 gacctggagc cagtcggatt ctgaagcagc tgacatgaga aaacggcagc agtcacaaaa
      301 tgaaggcacg caggctgtgt ctcaagcgcc cggaaaccaa aggcccaaca acacctgttg
      361 cttctgctgg tgctgctgct gcagctgctc ctgcctcact gtcaggaatg aagaaagagg
      421 agactcttcg gggagacccc cacacaccac caaaatggag agcatccagg tcctagagga
      481 atgccaaaac cccactgcag atgaagtctt gtcctggtct cagaattttg acaagatgat
      541 gaaggctcct gcaggaagaa accttttccg agagttcctc cgaacagaat acagcgagga
      601 gaacctactc ttctggctgg cctgtgaaga cttaaagaag gagcagaaca agaaagctgt
      661 tgaagaaaag gccaggatga tatacgagga ttacatttct atactgtcac cgaaagaggt
      721 cagcctcgat tctcgagtta gagaggtgat caacaggaat ctgctggagc ccagccctca
      781 catgtacgaa gatgcccagc ttcagatcta caccctaatg cacagagatt ctttcccaag
      841 attcttgaac tcgcagatct acaaagcctt tgtcgaaagt actgccagct ccacttctga
      901 atcttaattt tcatttgaaa ggccaaaaaa aaaatcattt cagagggctg ggatgggaaa
      961 taaaagtaat taaataacat cagaaatcga gttcctgaaa aaaacgacag gttggctgct
     1021 gggaaaagac aactgggaaa gtcgtttgtc tctattttta tcaaggttat ccatgattct
     1081 gttagggggt aaaaagcctg tgtaagaaaa tgagttgcca aattgagttt gtttgattca
     1141 acacttgctc tccttgcaag cgaactatgt tcctagtcct ctgaacaatc ccctagtgca
     1201 tctctagagg ccgcatgtgc aaagtaaaac cgcttcgtct gccctttact tgtgccatta
     1261 agtcagtagc ataccttgta tctgtattta aggacttctg tgcaatatgg tctcttagaa
     1321 acaattgcca acaaattggc cgtggtttgc attttttaag cataatctga tacacacaaa
     1381 ggctatttta aacatgtaac agtgatattt aaccacgcta catactatgt ttagtacatg
     1441 gactctgaag ccaatttttc tgtacatgtt aaaaaaaaaa gtgaccattg aaggacctta
     1501 ttgtgtgaga cctctggttg ttcactgccc acattctgac atttttgtta cagaagagtt
     1561 tgctatatat atattttaag agaaagaaaa gagagaaaaa gaaagaaaac aaaaatagtt
     1621 aacaatgata agaaaaattt taaaaagcac aaaacaatct gcagatatcc tgtctcgttg
     1681 aaaattccaa gaaggatact atttttaggt ctaaaagaaa gaaaagagtc tatgtatata
     1741 tcagatgtcc aatagtgtaa ttaatttatc aaagaaaggc tcttcagttc taaaagcatt
     1801 gcataaacct atgactgtca gcaggtaaac aataataagt tcagtaaccc agtttgggaa
     1861 tagaacggga agggtaataa agaaatgcct acatgtagca ctgtaaaagt cacctttgag
     1921 gagtcgcctc tgtgtggcgc gctcaccttg aacgtgtaat tcagtgaaaa gcttgagttt
     1981 ttcctaacca acattttaca agggattata gagaagaaag ccttcgatgt cagaccttaa
     2041 ctgttttcac cgtagtctct caagaaagac ttatttttaa cattgttaaa atcaaactac
     2101 caaccctcgt ccgtaactag aaggcagtgc agtgctcaat ccttttagct gccaatatta
     2161 ttttttataa ttacattaac tctttacacg gatactcaca tgaccatggt atgcatttct
     2221 gaccttcaga acagtatcgt cttgtgcaca aaaccaaaat tacaatcaat gtcatattta
     2281 tatcaaggtc ctacctttca atatcaaaat cccctggaga ctattttttt aatcttaaac
     2341 tcaatgaata tatgttgagt aacctttaaa aaatgaaaga tttaaaaaga tttataacca
     2401 ctgagaatac tggccttata ttaaggatga tattaaaatt aaaggttttg tttgtcattt
     2461 ttaactacct ctcagttttt aatttattaa acatattttt ttaagatgca agtttggagt
     2521 tttctttttc actttatttt acttgaaagg ttggcatcat gtttcttttt ccataaattt
     2581 aaaacatttc aagaattgtt ttttaagtga atatgatttt ctaatttata tagaattcag
     2641 gagctatgat taaaagggct attacatatt ccctatgcaa atattttaac tgttgcagtg
     2701 tttgacaaaa tgggattaaa aaaaaacagt ttgcagagtg gaaaacaaaa tgttgtgttt
     2761 acactggcac cgctgaccat cctactacgc tcagtacttt taaatacatt atttatggaa
     2821 acatagttaa aatgcaagat agaaggtatt tataatagtc atcttttagc aaatgcctgt
     2881 ggactctttt ctgaaagtgt tagtgtgttt aagacgcgct ttgctcatgt ctcctagata
     2941 tttactcttt gaatagtttc agtaatctgt cgagaaaaaa gatagctatg aagatgttta
     3001 caaaaaaaat cctatttttt cctaaagagt caagaaaacg taaaagcgtc gttgcttctg
     3061 ttgtgaagtc ccatcgttct aaatgatttc attgttttct tgataagtgt ttattatgct
     3121 aatatgatgt gtatgcctat ctagtgtacc atcatctcat ttctgtgttt gaggcacaat
     3181 gaattggtgc acatgaccag gagatttgta atatactacg aagccctgca tgcacaattg
     3241 tttttgatgt agactttatt atattccctg tactgcggat gctcgtgact tactgtcaca
     3301 ggtgatcttt acaatatctc tggactacta ggcgagttgt ctgcttgatc atgcatttac
     3361 tcttttacca aatgtaagaa gaggtaaggg ccgttaaagg gtcctcatct ctaacctagg
     3421 catttgcagt gtttgcttca aagttgctgt gtctttggag cctggttacg aagcttcact
     3481 gacgaggtcc taaggcggat ttgcacagcc gctgtccttg gcgatgctgt gtgggcagct
     3541 ctgtgttgaa ttcctatttc agggggatgg cttctcattt cacttctgaa tgtttcaagt
     3601 tttagagagt gtgcctgtgg acttgtgact atgccggttt tcaaagtatg gtgtgatttc
     3661 ttctgtttaa gtcacagagc tacaataaac aaacaaaagc cctcaactgg tgtctctgcc
     3721 accatttcaa gagcacaaca tttgctttat tcaaaattga ttgaattctc cttggggaga
     3781 ccctagcact ttaagtgaag caccttgcat tgatgattgc caagataact ttgtatattg
     3841 ttagaatccg ctaatgcaca cacaagaggt taatgcactt tctataggtc tgtctattgt
     3901 ggaaagaaaa ggagattgta taggtgacgt atatagaggt ggctcaaaga cagatgtctc
     3961 cataggtgga tcttacacat agacatgcta atgctggagg gagggtggct cctctttctg
     4021 gcttattacg atgtcatcca aagtaagcac acatgctctg acagcatgac aaggcacaga
     4081 tgaatgtaag caaaaacgga ccttgataca gaagttataa atgaaaaagt caaaattata
     4141 atatggcctt taaaacattc ttacaatgtt tataaatgac cagctgttct aacagtgtgt
     4201 cactgtgcct agaacattta ttagcgagca cccttcagtg tctcctagta taaagaatgt
     4261 gctctattta tttgatagtt gagtgtcaaa ggactgtaga aatagataga ctaatctgtt
     4321 gaaaacaata tacatctccc ccattgtatt aacttaatac ttgaatctta atttaagttt
     4381 attctttttt ttttctagaa ttttttaaat agtctcagaa aaagtcacat tataattgtg
     4441 gaaactacac ttgcaacaaa taaaaatttt caggtgcttt ggtgaaggtt tttaaatgga
     4501 aggaatggaa ataaagtata gaaaagtgaa ctttttgaaa aaccatccat ttgtttttaa
     4561 acggaagata tacctagacc ccccacataa catgaatttt tgaattcctt tggctttata
     4621 tattcgtata ttatctcgaa ataggaaata cagccaaaaa aattgggtta tctgtctatt
     4681 tagattggca gtgagtgacc aatctccaaa gtatctattt ttgaaactgt gagcgtactc
     4741 ctttctgttt tcaaatttcc gatcaacaga aaatgctgtc ctttgatagg agcacgccac
     4801 gcgtaataac gttagtaatt cttcacttgc cacgactgca ggtaaaacca ctaaaaccta
     4861 ccgagccttc cttcagaaca tatctgcaag attatgatat ggctaagata tcaccacaac
     4921 acacatagtg aatgaaagag cactggcttt gatttctgcg tatgttaaga aatattactc
     4981 ctacagaaat agtcctaagc ggctataagg gacatgcttt ctttcccact ggttgaagag
     5041 aacacaccat accatcattc tattgaaaac atggagagat ggagtgttcc ttagttgggc
     5101 aaatggggtt gagaactcat ttgattctca tgacaaatgc tccaagttgg gaaaaagcag
     5161 ttatctaaag cacccatgat gacaaccaca cgagatatca cagtgtcatg catacaatct
     5221 gaaattcagt tccctcctct tgtcttacat caagtatttt ctgttgcaaa ctttcccatt
     5281 gattcatagc ttcatcacgg catttcagct ttttaaacag ttagaagtgt gtgcgtccta
     5341 aactgatgat taagcaaact gtctaaggtc tgggcacatt tccgtttgaa aggacagagc
     5401 tggtatttac atccagagat ggtaggaaaa gtcatgtaac ctttctgaat ctgtttcttc
     5461 atctgaaaat gaatattgat tatggggtgt ccgttggaac aataatgttg catataataa
     5521 ttgatcaaga gttcttcagc ccagtcatag tcacattttt agtaagtgac attttagcgt
     5581 actctcccct tgtttccttg gaatggtttg gttagcacac aaagagggtt tcatcatgcc
     5641 attttcatac tggtgtcttg ttatatcctg ttctcttttg taccccactg cctttccctg
     5701 ggccttctac tttctctgct tattttttta aacatacttg aaaaatttaa atatgcacag
     5761 gcacacacac tcaccacaca cacacagcaa cacacacaga cacagataca cacagacaca
     5821 tgcacaagca cacatacaca cagacacatg caacaccccc acacacacat gcacagacac
     5881 atacacacag atacacactt aaagatggag acctaggaca taaaatcgcc atccccacga
     5941 atcagaaaca tagaatcaag ttagttacaa atacaccaag tatgccactg gatgacagag
     6001 ccaaaagcaa gttcataaag catgactgaa aatcaatccc ttcaatatta gtgtgactgt
     6061 caagtttatc atgatactct gaatagaaag attattaata caagtggcta agtgttcatt
     6121 aatagtttca ccaaatttta gaatattttc agcttaatgg aaaaattaca aaggcagtac
     6181 aaaatgccct ggtgtgttct ctgtgtctgg aaaacaatta ttcccaatta ataactaatg
     6241 ctgccccatc aaggttgtac acatcatcct gacacttctc ttgtcttctc tctacccttc
     6301 ccatcctaaa accatgtgac ctcttattgt cacccttcgt tgtatttctt tcagctgtga
     6361 ctctctataa atgttcttgt gtttttcaaa accttgacag ttttgagtgg aaatgacatc
     6421 tattgtgtag agcatcactc tgcagggtgg gatttctcat ttttagacta gcgcttttgg
     6481 tttctggaag gaataatgtt attctgttct ttctatcata aagatttgtt ttttatttta
     6541 tgtgtgtgag tgttttgtct gcaagtataa atgtgaccac atgtgtgcaa cacctaaggc
     6601 cagaagagtc cgctgaaatt ggagctacag atggtcttaa ggcttcatat gggttctggg
     6661 aactaaatca ggggcttcag taagagcagc aagtgcttta attgttgagc cacctgccca
     6721 gccctggata gccaacctcg ttacatgata tctcaaaggc acatgccacc cgggtaagta
     6781 ctcttgcttt ggggtccttg ctgttgctgt tgcagtcacc ctgtcacctg tttaaagcat
     6841 tgccttttgg atacagcctc tctgctgcca agtgatatgc atgcaaagaa ggtacctgag
     6901 agtgaaatag accctgcatt acactgtgca agaaaaacaa ccaacaacca accaaccaag
     6961 caaacaaaaa caattctggc caaagtctta gcatgaatac taggctccat taaaggatta
     7021 ctaacaaata ctacaaagaa aatggaatgg attaggaaat gaaatgaccc aaatcagtgt
     7081 tagcttggat atctacttat gaaaagtgca actgttcccg ctttcctgaa ataccccggg
     7141 tagttattaa atcctgctca catgctggat ttgaagattt tagtctcatt aattgtagca
     7201 agaggttgct aattactcat gcttaatgcc ttcctgtata tcatccactg agctgtgtgt
     7261 acaatgctga agtgtagagg acttgatgtt gctcctcaag ctttaacctg tttgtcacag
     7321 tgtttcttgt gtgtgatttt aaagagtttg caaaatgtta aaacgtattt taccgaattc
     7381 gactctgtga aattcatttt gaacgtgtct gatttcttac ttccatgctc accctattta
     7441 gtgatctatt tccacatttt gcattcactg atgtatttat tagtgaacca caaaaaggtt
     7501 ctgagtacat gaatacaaga gcagccctgc ttgtccattt tataatacca aaatatctgt
     7561 gggtactcat agttgactag aaaatccaga ttctttttct tgcagctcaa aattttctgg
     7621 gtttttattc cattgaacca atttcatcat ttacctatgt acaataatag acttcttgaa
     7681 agtgttacag tttttgccat gtaatagatt tgagcatgac aatactgtaa gaaaacccag
     7741 acgtctgagt tttcaaagga aatcaaatag gtgttttcat ttaactatat tgtggcaatt
     7801 tatgggtatt attgtaaaat gcatatgcat tacactgatt ttcttaatgt gttttgaatt
     7861 aataaagaat tctcccatgt atccttagac aa
//
LOCUS       NM_001437839            4091 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 8, mRNA.
ACCESSION   NM_001437839 XM_063281282
VERSION     NM_001437839.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4091)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4091)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4091)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4091)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4091)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4091)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4091)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4091)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4091)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4091)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063281282.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1901771.1,
                                           SRR26360194.2086800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1449           JAXUCZ010000002.1  217916935-217916983
            1450-1525           JAXUCZ010000002.1  217946550-217946625
            1526-1620           JAXUCZ010000002.1  217955065-217955159
            1621-1849           JAXUCZ010000002.1  217957098-217957326
            1850-1938           JAXUCZ010000002.1  217958485-217958573
            1939-4091           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4091
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1916
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 8 is encoded by transcript variant 8;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 8"
                     /protein_id="NP_001424768.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESS
                     NTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGM
                     DFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSE
                     ETRVWHRRDGKWQNIHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1452..1835
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1452..1835
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1449
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1525
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1620
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1849
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1938
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..4091
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag gagtcaactg agagctcaaa taccaccatt gaggatgaag
     1441 acgtgaaagc acgaaagcaa gagatcatca aagtcactga gcagctgatt gaagctatca
     1501 acaatgggga cttcgaggct tacacgaaaa tctgtgatcc aggcctcact gcctttgaac
     1561 ccgaagcatt gggcaactta gtggaaggga tggactttca cagattctac tttgaaaatg
     1621 ctttgcccaa aatcaataaa ccaatccaca ctatcatcct gaaccctcac gtacacctgg
     1681 taggggatga tgcagcctgc atagcataca ttcggctcac acagtacatg gatggaaatg
     1741 gaatgccaaa gacaatgcag tcagaagaga ctcgagtgtg gcaccgccgt gatgggaagt
     1801 ggcagaatat tcactttcat cgttcggggt ccccaacagt ccccatcaag ccaccctgta
     1861 ttccaaatgg gaaagaaaac ttctcaggag gcacctcttt gtggcaaaac atctgaaaac
     1921 cattcacatt tgggtcttct aattgtcaac agtgccacgt cttcattctg tcctcaaggc
     1981 acctggcggg gtgatcctgg gacatcctct cctcttcatg catgtttctg agtgcatgaa
     2041 gttgtgaagg ttctacgtgt aatgcatatg tgacacgtca tcttaccatg tgacacgcca
     2101 tcttaccatg tattccttcc tgtacattgt ttacactcca gctactggac ggatgttcca
     2161 tgcaaacgtc agttactgct ggcaaactaa agagggagct ccgacaagaa aactccgcaa
     2221 tactccaagt tcagctgatc catcaggttt ctctgtggat gccaagattc aaaagacttc
     2281 ataaaattac tgttcaatga atgacagtgt gtaagaggaa aggaaatctt tcaagaatgc
     2341 tgccattaat ctatttgggc ttctcattgg gattttgggg ttgatttttt tttcattttt
     2401 taaggcaaat atatatatat atatatatat atatatatat atatatatat atatatatat
     2461 gccttcagtt cctggtagaa atgaatggat gccttttctc tgaaagtgtt ggtgttggat
     2521 aaatggatgg ctatgtgagc caagtcctgg gtgattgtag gagcaagaat cgtttgctgt
     2581 tctaccatca aagccatgtt gatttgggtc gagctctgta tactggaaaa attcacatca
     2641 ttttctagtt tgattgcttt cagataggca cagttctggt gaatgcttgg cactgatctt
     2701 ggtttttctt tcctaaatct gtgttctgtt ttcattatat actatttgct cctttccttt
     2761 gtatttgttt tcttttccca ctcttttctt tatctttctc tctcccactt tctttctttt
     2821 ttatgttttc ctttctatag ctgatagtgt gtaaaaacag taacatttgc atatgaagtt
     2881 aaaataaaaa tcaaggtctt ctagaagcta aaactagcac ttccggtctc tcacggggct
     2941 gtggagttgt tagaagattt aaataaatac ttaaataaga gaggaatgaa ttcagcttag
     3001 gttaccactt gtgcataggt atccttgctc tgttgaaagt gttggaattg ttgagactta
     3061 agctaacagc agtaagagcc tgcttacaca gtcctggttc tccccaacta gatattgaag
     3121 accaagtgga gcctgaccag ggttgcatgc agagcacttg ttttggacct tccagactag
     3181 gaggcattta ctgcctcact ttcactagct agccacagga agagtgttct ccatcctcct
     3241 agaggttgaa cttgaccttc gtgactagtg cagttctagc ttctctcttg agtcacagta
     3301 gcatcctgat gccaggagtt aggcttttgt ccagattaaa acaacgagga aaaggaaatg
     3361 ccccagtttt ctttccgttt cccatttctt ctttgtcgat tcggtccctg ggagactgtt
     3421 tctccgcgct gaactgcttt atggtgcatg gaatctccat cagcgtactt ctaccctagc
     3481 cactcacact ccttagaagc tgatttttaa agcagaagca aggaagcaaa agtaaaacac
     3541 tcccttcccc tctttttcct catttcacct tttggtgttg attgctaatc actttagata
     3601 tattgttgct agtgaatgta tgatagatgg gttgaagctt ttctgataat tagcacatga
     3661 tttaaaacaa tatatattta aaacaaatat atacagtaca tgtattgagc cgtgttaacc
     3721 tgccaatgag atctgtgaaa aacgtaatgg cctcactttt ccctttgaat ttcttttacc
     3781 tttctgtgaa gcagctctgc gtggcataca tgtatttaaa aacacaaata gtggtagaat
     3841 gggttttttt tttacacttt taacttagca tgtggtgttg aagtattacc atagatccag
     3901 tttgtcttct gcactaagat gtgaggaaat cgtgatttgt tctctccagc acagtggaat
     3961 tacaccttca tcatcttcta ttgttttgaa aacactgcag tttaccatgg gacactgtat
     4021 ataattcttg ccgtaatggt aaatgacaaa ttgatatatt taagagttaa taaatttgtg
     4081 atttctgctg a
//
LOCUS       NM_021859               1641 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus megakaryocyte-associated tyrosine kinase (Matk),
            transcript variant 3, mRNA.
ACCESSION   NM_021859
VERSION     NM_021859.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Gunn,N.J., Gorman,M.A., Dobson,R.C., Parker,M.W. and Mulhern,T.D.
  TITLE     Purification, crystallization, small-angle X-ray scattering and
            preliminary X-ray diffraction analysis of the SH2 domain of the
            Csk-homologous kinase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 336-339
            (2011)
   PUBMED   21393838
  REMARK    GeneRIF: The CHK SH2 was expressed in Escherichia coli and the
            purified protein was characterized as monomeric by synchrotron
            small-angle X-ray scattering in-line with size-exclusion
            chromatography.
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Kuo,S.S., Moran,P., Gripp,J., Armanini,M., Phillips,H.S.,
            Goddard,A. and Caras,I.W.
  TITLE     Identification and characterization of Batk, a predominantly
            brain-specific non-receptor protein tyrosine kinase related to Csk
  JOURNAL   J Neurosci Res 38 (6), 705-715 (1994)
   PUBMED   7807586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced NM_021859.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087726.1, SRR26643298.37823.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000007.1  9112696-9112746     c
            52-111              JAXUCZ010000007.1  9112131-9112190     c
            112-225             JAXUCZ010000007.1  9111468-9111581     c
            226-341             JAXUCZ010000007.1  9111257-9111372     c
            342-561             JAXUCZ010000007.1  9110951-9111170     c
            562-655             JAXUCZ010000007.1  9110597-9110690     c
            656-721             JAXUCZ010000007.1  9109717-9109782     c
            722-821             JAXUCZ010000007.1  9109164-9109263     c
            822-906             JAXUCZ010000007.1  9108992-9109076     c
            907-980             JAXUCZ010000007.1  9108841-9108914     c
            981-1179            JAXUCZ010000007.1  9108550-9108748     c
            1180-1266           JAXUCZ010000007.1  9108173-9108259     c
            1267-1641           JAXUCZ010000007.1  9107711-9108085     c
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1641
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
     exon            1..51
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            52..111
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    67..69
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="upstream in-frame stop codon"
     CDS             103..1506
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     megakaryocyte-associated tyrosine-protein kinase; protein
                     kinase BATK; tyrosine-protein kinase CTK;
                     megakaryocyte-associated tyrosine kinase (non-receptor
                     protein tyrosine kinase); non-receptor protein kinase
                     protein"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein kinase
                     isoform 1"
                     /protein_id="NP_068631.1"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
                     /translation="MPTQRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKS
                     WYRAKHHSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGL
                     FLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTRDKG
                     AICTKLVKPKRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKV
                     AVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLR
                     TRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK
                     AELRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE
                     VSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKLGRELRSVGVAAP
                     AGGQEAEGSAPTRSQDP"
     misc_feature    103..162
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    127..303
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    127..303
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(148..150,154..156,163..165,175..177,232..237,
                     280..282,286..291)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(148..150,154..156,163..165,175..177,232..237,
                     280..282,286..291)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    331..624
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    331..624
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    order(364..366,418..420,481..483,487..489)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(364..366,418..420,481..483,487..489)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(484..486,565..567)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    order(484..486,565..567)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    661..1425
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    661..1425
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(700..711,718..720,724..726,757..759,763..765,
                     844..846,889..900,1033..1035,1045..1050,1054..1056,
                     1084..1089)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(700..711,718..720,724..726,757..759,763..765,
                     844..846,889..900,1033..1035,1045..1050,1054..1056,
                     1084..1089)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    1435..1503
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            112..225
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            226..341
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            342..561
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            562..655
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            656..721
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            722..821
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            822..906
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            907..980
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1179
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1266
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1641
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagccaggg acccaggcag ccacagtcct gcggtgccgc actgggatgg ggtgaaccct
       61 caattctaag gagcttggca ccccacgcct gctgcagcta agatgccaac gcaacgctgg
      121 gcccctggga ctcaatgtat gaccaagtgc gagaactcac gccccaagcc cggtgagcta
      181 gcctttcgaa agggtgacat ggtgaccatc ttggaggcct gtgaggacaa gagctggtac
      241 cgagccaagc accacagcag tgggcaggaa gggctgctgg cggctgctgc tctgcgacag
      301 agggaggccc tttccacaga ccccaagctc agcctcatgc catggttcca tggcaagatt
      361 tccggtcagg aagccataca gcagctgcag ccacccgagg atgggctgtt cctcgtgagg
      421 gaatcggccc gtcaccctgg tgactatgtc ctgtgtgtca gtttcggccg tgatgtcatc
      481 cactaccgtg tcttgcatcg agatgggcac ctcaccattg atgaggccgt gtgtttctgt
      541 aatctgatgg acatggtaga gcactacacc agggacaagg gcgccatctg caccaagctg
      601 gtgaagccca agaggaaaca gggcgcaaag tccgcagagg aagagctcgc caaggctggc
      661 tggctgctag acctgcagca tctgactctg ggagcacaga ttggagaggg agagtttgga
      721 gccgtcctgc agggcgagta cttgggacag aaggtggccg tgaagaatat aaagtgtgat
      781 gtgacagccc aggccttcct ggatgagacg gctgtgatga caaagctgca gcacaggaac
      841 ctagtgcgac tcctgggtgt gatcctgcac cacggcctgt acattgtcat ggaacacgtg
      901 agcaagggca acctggtgaa cttcctgcgc acgcggggcc gtgcgcttgt gagcacctct
      961 cagctcctgc agtttgctct tcacgttgct gaaggcatgg agtacctgga gagcaagaag
     1021 ctggtacaca gggacctggc tgctcgaaac atcctggtct ctgaggactt agtggccaag
     1081 gtcagtgact ttggcctagc aaaggcagag cttaggaagg ggctggactc aagtcggctg
     1141 ccagtcaagt ggacagcacc cgaggctctc aaaaatggga ggttctccag caagtcggat
     1201 gtctggagtt ttggggtgct actgtgggaa gtcttctcat atggaagagc cccatacccc
     1261 aagatgtcgc taaaggaggt ttcagaggct gtggagaagg gttaccgcat ggagcccccc
     1321 gacagctgcc caggccctgt gcataccctc atgggcagct gctgggaggc tgagccctcg
     1381 cgcagaccac cgttccgcaa aatagtggag aagctgggtc gtgagctccg cagtgtgggc
     1441 gtcgcagccc ccgccggggg acaggaggct gagggctcag ctcccacacg gagccaggac
     1501 ccctgacccc tgaactggaa agcaagagga cacagatgta gggtcacagg gccagggtga
     1561 gccagtgcac aggctccgga gcccctggga tccccgttac tgggacaccc cataaagagt
     1621 gattggaagg attttgtaca a
//
LOCUS       NM_001437846            9485 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus prolactin receptor (Prlr), transcript variant 3,
            mRNA.
ACCESSION   NM_001437846
VERSION     NM_001437846.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9485)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   2  (bases 1 to 9485)
  AUTHORS   Vergara-Castaneda,E., Grattan,D.R., Pasantes-Morales,H.,
            Perez-Dominguez,M., Cabrera-Reyes,E.A., Morales,T. and Cerbon,M.
  TITLE     Prolactin mediates neuroprotection against excitotoxicity in
            primary cell cultures of hippocampal neurons via its receptor
  JOURNAL   Brain Res 1636, 193-199 (2016)
   PUBMED   26874070
  REMARK    GeneRIF: This study demonstrated that the Cultured neurons
            expressed mRNA for both PRL and its receptor (PRLR), and both PRL
            and PRLR expression levels changed after the excitotoxic insult.
REFERENCE   3  (bases 1 to 9485)
  AUTHORS   Rojas-Duran,F., Pascual-Mathey,L.I., Serrano,K., Aranda-Abreu,G.E.,
            Manzo,J., Soto-Cid,A.H. and Hernandez,M.E.
  TITLE     Correlation of prolactin levels and PRL-receptor expression with
            Stat and Mapk cell signaling in the prostate of long-term sexually
            active rats
  JOURNAL   Physiol Behav 138, 188-192 (2015)
   PUBMED   25446202
  REMARK    GeneRIF: Results showed that an active sexual life, with constant
            execution of sexual behavior, produces a sustained increase in
            serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
REFERENCE   4  (bases 1 to 9485)
  AUTHORS   Arumugam,R., Fleenor,D. and Freemark,M.
  TITLE     Knockdown of prolactin receptors in a pancreatic beta cell line:
            effects on DNA synthesis, apoptosis, and gene expression
  JOURNAL   Endocrine 46 (3), 568-576 (2014)
   PUBMED   24114406
  REMARK    GeneRIF: PRLR signaling is required for DNA synthesis and survival
            of rat insulinoma cells
REFERENCE   5  (bases 1 to 9485)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 9485)
  AUTHORS   Ali,S., Pellegrini,I. and Kelly,P.A.
  TITLE     A prolactin-dependent immune cell line (Nb2) expresses a mutant
            form of prolactin receptor
  JOURNAL   J Biol Chem 266 (30), 20110-20117 (1991)
   PUBMED   1718958
REFERENCE   7  (bases 1 to 9485)
  AUTHORS   Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.M.,
            Edery,M., Djiane,J. and Kelly,P.A.
  TITLE     Expression of two forms of prolactin receptor in rat ovary and
            liver
  JOURNAL   Mol Endocrinol 4 (8), 1136-1143 (1990)
   PUBMED   2293022
REFERENCE   8  (bases 1 to 9485)
  AUTHORS   Zhang,R., Buczko,E., Tsai-Morris,C.H., Hu,Z.Z. and Dufau,M.L.
  TITLE     Isolation and characterization of two novel rat ovarian lactogen
            receptor cDNA species
  JOURNAL   Biochem Biophys Res Commun 168 (2), 415-422 (1990)
   PUBMED   2159291
REFERENCE   9  (bases 1 to 9485)
  AUTHORS   Boutin,J.M., Jolicoeur,C., Okamura,H., Gagnon,J., Edery,M.,
            Shirota,M., Banville,D., Dusanter-Fourt,I., Djiane,J. and
            Kelly,P.A.
  TITLE     Cloning and expression of the rat prolactin receptor, a member of
            the growth hormone/prolactin receptor gene family
  JOURNAL   Cell 53 (1), 69-77 (1988)
   PUBMED   2832068
REFERENCE   10 (bases 1 to 9485)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.8254.1,
                                           SRR26360172.275651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000002.1  60861658-60861882
            226-285             JAXUCZ010000002.1  60992578-60992637
            286-395             JAXUCZ010000002.1  61012956-61013065
            396-528             JAXUCZ010000002.1  61016362-61016494
            529-698             JAXUCZ010000002.1  61018046-61018215
            699-868             JAXUCZ010000002.1  61027952-61028121
            869-1010            JAXUCZ010000002.1  61029594-61029735
            1011-1110           JAXUCZ010000002.1  61030181-61030280
            1111-1180           JAXUCZ010000002.1  61030794-61030863
            1181-9485           JAXUCZ010000002.1  61032628-61040932
FEATURES             Location/Qualifiers
     source          1..9485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..9485
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
     exon            1..225
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            226..285
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            286..395
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    308..310
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="upstream in-frame stop codon"
     CDS             341..2173
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; PRL-R; lactogen receptor"
                     /codon_start=1
                     /product="prolactin receptor isoform a precursor"
                     /protein_id="NP_001424775.1"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
                     /translation="MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     QMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFT
                     MEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESS
                     VEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVK
                     PTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQ
                     STNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVL
                     KLSKALETGEEEVAEQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDG
                     VLSLFPKQRENNQTEKPGVPETSKEYAKVSGITDNNILVLVPDSRAQNTALLEESAKK
                     APPSFEADQSEKDLASFTATSSNRRLQLGRLDYLDPTCFMHSFH"
     sig_peptide     341..397
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    395..685
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    395..685
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     mat_peptide     398..2170
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /product="Prolactin receptor. /id=PRO_0000010981"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2)"
     misc_feature    500..502
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    635..637
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    704..997
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    704..997
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(704..706,917..919,962..964)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(704..706,917..919,962..964)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    719..721
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    968..982
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: WSXWS motif"
     misc_feature    order(968..973,977..982)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(968..973,977..982)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1028..1099
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     transmembrane region"
     misc_feature    1124..1150
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Box 1 motif"
     misc_feature    1289..1405
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1712..1786
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2030..2092
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            396..528
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            529..698
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            699..868
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1010
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1110
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1180
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..9485
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacacgc ggctggcgac tgcggagcag aggctaaaat ccccagacgc cgggtcttct
       61 gggctgggct ttccccgcct tcctgctctg tctcactcgc tcctctcctg cgttctggat
      121 tttacacggg gctcaggaaa cagctttacc tgtcagagac agagctcacg tcctttgcag
      181 gaagtgcaca gcctctggta tggcagactt ttctctccag cagaactaaa ggacacttct
      241 ctgtgaaggt gagcactgca gatgttttgc acatgagccc tgaagggagc ctctgataca
      301 ttgcctatag caagaagaag gggccaacct gaagaaaaac atgccatctg cacttgcttt
      361 cgtcctactt gttctcaaca tcagcctcct gaagggacag tcaccaccag ggaaacctga
      421 gatccacaaa tgtcgctctc ctgacaagga aacattcacc tgctggtgga atcctgggac
      481 agatggagga cttcctacca attattcact gacttacagc aaagaaggag agaaaaccac
      541 ctacgaatgt ccagactaca aaaccagcgg ccccaactcc tgcttcttta gcaagcagta
      601 cacttccatc tggaaaatat atatcatcac agtaaatgcc acgaaccaaa tgggaagcag
      661 ttcctcggat ccactttatg tggatgtgac ttacatcgtt gagccagagc ctcctcggaa
      721 cctgacatta gaagtaaaac agctaaaaga caaaaaaaca tatctgtggg taaaatggtc
      781 cccacccacc ataactgatg tgaaaactgg ttggtttaca atggaatatg aaattcgatt
      841 aaagcctgaa gaagcagaag agtgggagat ccattttaca ggtcatcaaa cacagtttaa
      901 agtttttgac ctatatccag ggcaaaagta tcttgtccag actcgctgca agccagacca
      961 tggatactgg agtagatgga gccaggagag ttccgttgaa atgccaaatg acttcacctt
     1021 gaaggacaca accgtgtgga tcattgtggc cattctctct gctgtcatct gtttgattat
     1081 ggtctgggca gtggctttga agggctatag catgatgacc tgcatctttc caccagttcc
     1141 tgggccaaaa ataaaaggat ttgataccca tctgctggag aagggcaagt ctgaagagct
     1201 gctgagtgcc ttggggtgcc aagactttcc ccctacttct gactgtgagg acttgctggt
     1261 ggagttctta gaagttgatg acaatgagga cgagcggcta atgccatccc attccaaaga
     1321 gtatccaggt cagggtgtta agcccacaca cctagatccc gacagtgact ctggtcacgg
     1381 aagctatgac agccattctc ttttatctga aaagtgtgag gaaccccagg cctacccccc
     1441 tactttgcac atccctgaga tcactgagaa gccagagaat cctgaagcaa atattcctcc
     1501 caccgtggac ccccaaagca ccaaccccaa ttttcatgta gatgcaccca aatcttcaac
     1561 atggccatta ctgcctggcc aacacatgcc cagatctcct taccacagtg ttgctgatgt
     1621 gtgcaagcta gccggaagtc ctgtgaatac actggactct ttcttggaca aagcagagga
     1681 aaatgttcta aagttgtcta aagcccttga gactggagag gaagaagtgg ctgagcaaaa
     1741 aggggcaaaa agcttccctt ctgacaaaca aaacacacct tggccgctgc tccaggagaa
     1801 aagccccact gtctatgtta aacccccaga ttatgtggag attcacaaag tcaacaaaga
     1861 tggagtgcta tcattattcc ccaagcagag agaaaacaac cagacagaga agcctggggt
     1921 tcctgaaacc agtaaggagt atgccaaggt gtctggcatt acggataaca atatcctcgt
     1981 attagtgcca gactcacgag cccagaacac agcgttgctc gaggaatcag ccaagaaggc
     2041 tccaccatcg tttgaagctg accaatctga gaaagatctg gccagcttca ctgcaacctc
     2101 aagcaaccgc agactccaac tgggtaggct ggattacctg gatcctacgt gcttcatgca
     2161 ctcctttcac tgatagctag acttatggaa cgattggcta aactgtgatt tctcttcagg
     2221 taacactaca gagtcatgaa gtaatgtggt ctgctagcaa atgttacagg atgtgggtat
     2281 aaaaaagaaa aaaagaaaaa cactacttca ctccttctca cgcttgtgtt catcgcttgc
     2341 ctctttttaa cagctgatct ccaaaacaaa tcaacttgtt tcctgtgatc ttgctctttg
     2401 cgcgcatata tatatatata tatatatata tatatatata tatatatata tattgttcaa
     2461 tgtaattaaa agcacatcgc ttattattct tgagggatgg tgccaacagg tattagcctc
     2521 tgcaatagat ctgtcatctg acaaaaggta tgatatagtc aaaatgactt agcacaagaa
     2581 gatgacagat gggttgaaaa tgccatgaaa actgctctta agaactgagg gctaagcctt
     2641 tacactcctc tttcattttc atgatgatgg tccagatagt gcactttttt gaaagaatac
     2701 attccaggac accagccaaa ctgtttacat cagtcgcttt accttaagga cccattgcct
     2761 gtacgcaaat gggttcaagc ccctaatgct ttcttaaggt gattcgagta tgttaagcct
     2821 gggttattct gctgaaactt tattttattc taaggcttct cgagtgtata gtttgggtaa
     2881 ataaaatttt cttacaaaga aaggccaatg aattccacat agggaaccat ttcacatgct
     2941 ctccttgctt catttgagca gggggtgact tgttataaac ccgagtattt tcttagtaga
     3001 aaaaaaattt cccaaagact aactttaatc taaaaggtaa tcattgcagg actctaatag
     3061 gagtgttgcc ttactgtaca taaaattcta ctttaataca aacccgtaag tttcgcaatg
     3121 tatttttgaa gactattttt ctatcgctta ggtaaagtaa agactatttt ctaacttccc
     3181 agtattgctg tttacgtatt cgagtgagta gagtaatttc tgctgccaag ttacaatgag
     3241 tattcaaagt tgttcagtgt atgcagtccc tgttaaactg aagtgccagg caacccattg
     3301 cccattgagg aatgcaaagt ggatgaaaac accaattgag tacaatagag taaagtttat
     3361 ctgattattt tatccccagg atacttcaaa cagcaaccat cactaacttt gggttttaga
     3421 gctttctata gacctatttc tcccatgagc ttagggctct gcccacgtat gagtgaatct
     3481 cacaaaccac catgaacaag gatagtggtg gtggatgagg gtttccaaga cagaaatctg
     3541 actttgtttc atttactttt atcctgaaca caaaaggatt ttgagcaaaa tcaaacgtca
     3601 gcatctcctt ggaatacatc catttgtaag atcttggcag aggttgtgct tacgtcaggg
     3661 atgttaagat aaaagtttta gggaagcaag catctgccca gtgataagaa cagttttaaa
     3721 ggtcagggga tggtagaatc ggcaaggcaa gtccaagggc aggcttcctg agaaggttca
     3781 aagcaaagcc ttggatctcc aacagcatct atgactcacg cttcctccac ttctcaccta
     3841 ttggcaaatc aagtctctct cctttcaccg actggatgtg aagactgaac tcagatcttg
     3901 tgacgcccag cgtcacatgg tggtagaagc aggactcaaa gattctccaa tgactgaaag
     3961 gaaacctaga gccaatgaac ttccagaact ccaaatgcaa acagccaaag cttatattcc
     4021 taatacacaa agtatcttgt gaatggcaga agcatttgag aaagattgtc caggctcacg
     4081 caataccctg aaagcctcca tactgaatgt ctaagaacca actgcatcac aggggcactg
     4141 cttggaaatt gtgtttgcag cttcttaagc ttcttcgaag acatacagaa ttggagtctg
     4201 aattttactg cctttactca gttcccagat aactcacagg catgatcgag ctggagaagc
     4261 attttttttc tatgatcgtt ttcatgacaa attatttttc tctctgttgc aaaggatgaa
     4321 gcaagcctat ttcactcaaa ataaacactg tacgtaaaga gaaaacaaaa acaaaactct
     4381 tagtgatttc agattcacat aatgatgtaa cttatataaa gtcacacaag acaatgagat
     4441 gcaaaatata cataaacttc caagagggtc agtgaacttc actcaccttg aaaatcactg
     4501 acaaagaaga taaattccta agccagtgca gactaaaccg tctttcccaa catagtctat
     4561 cctaataaat caatgcattt atttacaaat caccactata aaattgatag tgcatcgctt
     4621 gaaatttcta aaaatcggct tcagatatat aattttgcaa atgtggaaaa catggctgtc
     4681 tgaagttgtt gcatcacaaa aataagttag cattcacgga agaaaatcaa atctacatag
     4741 ttctactcat ttattgaatt tttgtggtca aatattttca atctaaagct tggatgaaag
     4801 aaggcatatt aggggtcaag atacctgggt tctagtcctg tttgccttgg aaagaccaac
     4861 tgcctattgt agctttctct gtgttggacc aatcatttct acagcctttt gaaattcagt
     4921 ctctttgatt ctatggctca gtgaataatc agaaccaatc ccttgcatct taatgacgtt
     4981 ttcaggcaat tagggaaaca cagagtcact ttcattcatg tgctcatcct gcttcgctct
     5041 ttaaagtctc agcacccatt tgtcttcaca tactgaacat gtatttcaca ttatatggac
     5101 acggtgtaag tcagactcta ggatcatgtg caaatatgtg tgctaaggta agatgtagca
     5161 ctaagaaaga cacaggaaat gagacataag tctttagaaa aagtacgctt tatgcatcaa
     5221 gccatgctca ttcctacatg gagccaacag cctcaaagct ctgttctcgt atttggttgt
     5281 tgcctgtttt cccatcatct tgtttaatga ataaccattg tccatgtaga ttaaagaacc
     5341 tttttttctg catcattttt aaaaatgtat agttttctaa gcaactatct aaaaatttca
     5401 agttatgaag tacatggaaa ctgaatatat tcattgactt taggacacaa atggcaaaat
     5461 gttctctgat aaattttaac aagtacatag aaagaacttc actatgagca caatttacca
     5521 tcagcagtgt cactgacttt taatagatga tacattctcc taagtgcctg agaccaatcc
     5581 tggtggtcag ttataggtca atgattcact gtaaaccagt ttggtgggaa acagtcaagc
     5641 ccttgttgca tgtgtaaaag taaagctggg agactcttta cttgatataa tccaagggaa
     5701 ttggtgaatc ctcaattaat gaacaaccaa aggacctgaa ctccagggga aagtttgtcc
     5761 tgatgaaaaa ttagctcttt ttcttttctc tttagctgcc catcatttgt aaaatgactc
     5821 agcctgccct tagcaacctc aagttagcat agacaagaaa gaaagagatt tgtatatgtt
     5881 tacaaagtgc ctttctttat ttttaaaagg tttcattttg gaagaaaaat gcgttgattg
     5941 gaaggcaaat tttatcttaa atggatttct tttaaataaa tggagaaatg aacaaaaaag
     6001 ggggatgaca aaatgttcta aagactaacc aacaaaatgt cagggatttt tttttgcata
     6061 tagttatgtt gaatcatcac agaactgaat aatatcaatc actttacctg agtctgagca
     6121 tgattggtga tgaacctgaa gcctgtaatt caagactttc cattctgaaa aaaaggttga
     6181 tgcattcttg aatgattcac tgaatcgtgt gcctggccct gaagaggcca atgtgtatac
     6241 ttcgacgctc tgcacacaga tggaaaagta gtaatgacct tgaaatctct cctgtgactt
     6301 gctgtggatg aaagtttcat atatacttca tctaaccagg tttcttttct gacttttttg
     6361 gctcaagcac aatactgact gatgctagta ggagagcctc tgagccctcg gtgtccagct
     6421 ctgggtcata tcactgctac taaataggat tctagacctt gaattttttc aaattctgac
     6481 caccggtttc ccctctttta aataagtagg gtgactctct caaaaaacaa agtttctaca
     6541 atttcttcta ggtctgtctt taattctcat gagttaagta aaatctaaga ttgtgggtga
     6601 aaagcccagg ggccacagcc aacatgcccc taggcagtga atgcctgaga ctgtgtgaag
     6661 aaatgcttaa cagaaaacta agatccatgg ctccaaatca ggtagatcag aactcttgca
     6721 actctgcctc ctcgctgttt ctacattcgt agagcctttt cagtccctct ttccaagacc
     6781 tgctattctc cctaaagatt aattctgtag aatagtaaag ttgtgcctac aggaaagaaa
     6841 ttacccataa acagtgattt gactctgcat aagatgaatc tgttaactct ccacacagat
     6901 acaaacctaa aatgaggtca taaataatgc ttcagtttga tatgaacatg ttaaagattc
     6961 aactcattat ctaataaatc tgggctgtct tgatgagtag gtgttggctg tctttaaaag
     7021 aaagtttaaa atatagaact atttgcttca gagtttatgg ttaaaccaga aaatctactt
     7081 ataattagag tcctttccta tgaataatag ccattatctg tgaatcgcat gggaattttc
     7141 cctgagactt ttattttcca aaaaggtaac tttagatttg agctctgtgt gtatcaattt
     7201 ccaatggagg aaaaaggtaa aaacagaatg ctccaaaatg tgggacatat cagaacccca
     7261 ccaaatggag tatccattca ctcaaatctt actggaaatg gtaaatttac atgtaattgt
     7321 gagttaattg cagaggggta aacataactc ataagaccat aggctaacag cagttcttgt
     7381 aacaccaatt cctttgatct taagttataa agcattgaga cacatacagt agaaaggcaa
     7441 ccatctaaac agtctagtca atgagtaaag ggactcacag ataatcttac catggtgatt
     7501 aatatttacc tactgttgtt taaaaagaga aggaaaaatt ctaaaagttt ttgtgactaa
     7561 aacagtacta tcaaacataa actttaatag ttatggtcaa gttgtgcccc cccgaataca
     7621 ctcaaaatac agacttgatt tttctgtgca cattttgcaa attggggcgg caatcttttt
     7681 atcacattct ctaaaatgaa aaacaataaa aagaaatttt atgtgaaaat acctctgaaa
     7741 gtcatttgtt ttactaaatt cctgagaaac agatttggaa tttttaaaac tacctccctt
     7801 ctacatccta atgaccttcc ttcaaagctg cttatagtta gaaatgaaag ataccacatg
     7861 ttatgtttgg actggtgttt gatggaatat ttgatatact tttcctgtga cactcctaac
     7921 tctattattt taccctattt ttgctttttg tgatccaaaa cctatatatg ccatattgaa
     7981 atacataatc ctcttgttgt aaaatttatt atgtaataca agtaaaatca ttatttaatg
     8041 acttatgctc taaccatatc taatttcaat ataattgtgt ctatgtaaag tgaaattaaa
     8101 tatatgtaat catgtatgta atcatatatt tctgttgaaa ctgtgaatgt actgattttc
     8161 cctttaatct ttgtctacaa gtgatagtat atgtcattgt ataactgact tggggtacta
     8221 atgtgtttaa agtacaatcc accaattatt gaaatgtcaa ccttttggct tcgcttcttg
     8281 tgatcccaga gcgttctttg caccttgaga cttgcttttg tgcttttgtg ctctgtcatt
     8341 aattttaaac aatgtaagaa tctcttgtat aaaccaaagt aatcagatgc agcccactga
     8401 gtgatcatgc cttctgtaaa gccatactga agcacagact ccgctgtcgc ataaggtccc
     8461 ctctttccag agctgccact acctcgctcc tgctctttcc ctacaaattg ccaagctaag
     8521 tttaccctta agtggaaaat tagaattcat cgctattgtt accattttta acctgataat
     8581 aaaccttcta attcattact ttgcagatat atgctaggtt ttatgaataa ctatttttac
     8641 atcttggtat tttgtagact ttggctgatg agtaaagtac agaaagacta tacagtaagt
     8701 catcagattt aaaagaaaaa agtcatagag tgcaggtatt tttttcctat cagtgagtca
     8761 actcaagatg gttggccaaa gcaattacaa cctgggtccc tatatttgaa gcacccaatt
     8821 cagtgcctgg ctctaagatg tttatcccct ttgcctctct tggttctatt ttttgttgct
     8881 gttgtttgaa atgcaaatga acagaattac atggatgtag aggaagtgat tttctaattt
     8941 tttgctgcca gatctgtaat tataaattcg caatttaatt tccccaaact cccaagaaat
     9001 aaatattctc tttatttgat tttaatcatc aaatacatta tggtattgga agagtcgggt
     9061 atttatcaga aacaacattg tttcgaactt aaaagactca tttttatgtg tcactactgt
     9121 gatatcaact gttttctttt agcattaaag ggttatatgg ttatatggtt aaagggtctt
     9181 atgatttatc ctcctacatt ttttactctg caaatcttga gttattgcac attgtacttc
     9241 ctagttttca agaatctatt catttgtctc catcaacttt gttgggacaa catggacagt
     9301 taaaactttg tcaattatat gaagattatg ctaatttctc tcacattttt actgcatgct
     9361 aaaaataatg cttgccaaat ggaatcttag acatcccaga ataatatggt cactatattt
     9421 ctatttctgt cattattgaa aatacccagc tcagtgcctg gctcaataaa tgtttgtttc
     9481 ccttg
//
LOCUS       NM_001437832            3244 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            10, mRNA.
ACCESSION   NM_001437832
VERSION     NM_001437832.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 3244)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 3244)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 3244)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 3244)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 3244)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.733.1,
                                           SRR26360172.1815795.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               JAXUCZ010000001.1  105321608-105322211 c
            605-1076            JAXUCZ010000001.1  105320341-105320812 c
            1077-1226           JAXUCZ010000001.1  105319532-105319681 c
            1227-1321           JAXUCZ010000001.1  105319331-105319425 c
            1322-3244           JAXUCZ010000001.1  105317326-105319248 c
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3244
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..604
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1076
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    656..658
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             671..1456
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 2 is encoded by transcript variant 10"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 2"
                     /protein_id="NP_001424761.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGYVDCC"
     misc_feature    <1124..>1414
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <1124..>1414
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            1077..1226
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1321
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..3244
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagtgcag actctggagg ggctgccggg acgtcgcagc gtgcacgcag gttgtggggt
       61 ttggggtgac cccagagggg cggacactca ggcccagtgt ggaatactgg gtgaaatctg
      121 gaaactgcaa ccaggtccgg ccctgggata gagactcaga cctggtgttg cgttgcagcc
      181 ctggagtggg ttgtacaggc tagggatacg gggacaaacg gtgctcggtc cgcaacctgt
      241 gggtggagcc aagatctggg gccttgggag tccgagaccc agactaagat ggagcattta
      301 taaggctctg tgttgtctga tttgagggcc tcatacgggt ccctacagct tttaagggtg
      361 gggcagatac atgggcgtta aaggagcggc caagagcagc gggcagaggt agctcctgag
      421 ggacagtatt catgggggcg tgtcccaggc tgctgtgggc ctgggaaagg tgacaaacta
      481 gtcaggcgac tgggttgaac tgccaaaggt gagcaattag gaggttggaa cctttcgctg
      541 agcgggagaa ggggctcagt cctggctcac cttcttcctg gagagaactt ggccagacac
      601 ccagaggctg gaccaggagc tgaccacaag ccaagagtct agaagtgctt gggactgaac
      661 caaggtcgtc atggccccac caccactact gccagtggct gccagcactc cgatcctgca
      721 cggcgagttt ggttcctacc cagcccatgg ccccaggttt gccctcaccc tcacgacaca
      781 agccctacac atacagcgac tgcgcccaaa gccagaagcc cggccccgag atggtctagt
      841 ccctctggac gaggtctcag gctgtggcac tctgcagagc cgtagccccg aagacactgc
      901 agcctacttc tgcatctaca cctacccacg tggccggcgt gggggccggc gcagagctac
      961 tcgtaccttc cgggccgacg gggccgccac ttatgtggag aatcgtgcag aggcccagcg
     1021 ttgggcaact gctctcatgt gtctcctccg aggagtgcct ctgtctgggg accaggaaat
     1081 cacccctgaa ttgctgcccc ggaagcccag gctgctccta ttggtcaatc cttttggggg
     1141 gcggggcctg gcctggcagc gctgtatgga ccacgtggtg cccatgatct ctgaagctgg
     1201 gctgtccttc aacctcatac agacagaacg acaaaaccat gcacgtgagc tggtgcaggg
     1261 gttgagcctg agtgagtggg aaggcattgt cactgtgtcc ggagatgggc tgctttatga
     1321 ggtgctgaat gggctcctcg accgcccaga ttgggaagac gctgtgcgga tgcccattgg
     1381 tgtcctcccc tgtggttcgg gcaatgcact agctggggca gttaaccatc atggcgggta
     1441 tgttgactgc tgctgagaca gctagggata cctgctaaag agagggatga gtctttggga
     1501 cttcagggtc tgatatctta ttatccagca cccactaccc cttacccaag agcaagttct
     1561 gtggctggcc tgtagaatat cttcagtcag ggatgcttat ggggggctcc aggttatgac
     1621 tcctggtggc aggcattgct gcgcctgcca ccctttcccc tctgtgtctc actcctcatt
     1681 gccctttccc attgtgacac ctctctctga ttgtgaaggt ttgagcaaac tgttggtgtt
     1741 gacctgttgc tcaactgctc gcttcttctc tgccggggtg gcagccatcc tctggacctg
     1801 ctctctgtga cgctagcctc aggatcccgc tgtttttcct tcctgtcagt tgcctgggga
     1861 ttcttgtcag atgtggacat tcacagcgag cgcttcagag ccctgggcag tgctcgattc
     1921 acactgggtg cagtgctagg cctggccaca ttgcatacct accgtggacg tctctcctac
     1981 ctccctgcta ccacagaacc agccttgccc atcccaggcc atggtctgcc aagagccaag
     2041 tcagaactag ccttggcccc agccccagcc ccagccgcca cccactcacc tcttcatcga
     2101 tctgtgtctg acctgcccct gcctcttccc cagcctgccc tggcctcccc tggctcccct
     2161 gagcccctgc ctgacctgtc cctcaatggt ggtggtccag agctgactgg agactggggg
     2221 ggagctgggg atgcaccttt gtccccagac ccattgctgc cttcatcccc caacgctttc
     2281 aaaacagctc agctttcacc catcgccgaa gggccctcag aaatgccagc atcagggctg
     2341 ctgcctccca tccacaatgc tccagaagcc tctacctggg gcccagcgga ccacctgctc
     2401 cctcccctgg gctctccact gccccaagac tgggtgacaa tagaggggga gtttgtactc
     2461 atgttggcca tcttgccaag ccacctctgc gcagacctga tggcagcccc acacgcgcgt
     2521 tttgacgatg gtgtggtgca cctgtgctgg gtgcggagcg gcatctcacg ggccgcactt
     2581 ctacgaattt tgctggccat ggaacatgga aaccacttca gcctgggctg cccacatctg
     2641 ggctatgctg cagcacgtgc cttccgcctt gagccactca cgcctcgtgg ggtgctcact
     2701 gtagatgggg aattagtaga gtatgggcca atacaggcac aggtgcatcc aagtctcgcc
     2761 acactgctca ctgggcctgc aggtcaaaag cctcgagcct gaatgagccc aaagcatgcc
     2821 aagttgatgg gaccagagcc ccataggcta aggtctacct tttataggta gaagtggggc
     2881 ctgaactcag aactgcaagg gtagagagtg ctccagaccc tcagttccca gaggacccta
     2941 gaggctcgag ggtgggatct gcctttcttg atgtccaatg atggggcctg gaatgtatga
     3001 gctagcaagg cttcttcagc ttactgtcca gtcagggttt cttcttgcct atttcggtgc
     3061 ctctacttga ctggccaatc agcccttgag gggcaggttc ccccaggtgg tccctagatt
     3121 tgcactaatg ttcccctggc cagttagggg tgggatgttc tgtgtcttgt gtgtccctgt
     3181 ccctagtcta aaaagcaatt gaaaaggtct atgcaataaa ggtgttgctt tctctggacc
     3241 tgca
//
LOCUS       NM_017110                834 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus CART prepropeptide (Cartpt), transcript variant
            1, mRNA.
ACCESSION   NM_017110
VERSION     NM_017110.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Casini,A., Vivacqua,G., Vaccaro,R., Renzi,A., Leone,S.,
            Pannarale,L., Franchitto,A., Onori,P., Mancinelli,R. and Gaudio,E.
  TITLE     Expression and role of cocaine-amphetamine regulated transcript
            (CART) in the proliferation of biliary epithelium
  JOURNAL   Eur J Histochem 67 (4), 3846 (2023)
   PUBMED   37859350
  REMARK    GeneRIF: Expression and role of cocaine-amphetamine regulated
            transcript (CART) in the proliferation of biliary epithelium.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Schuller,J. and Koch,M.
  TITLE     Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats
  JOURNAL   Behav Brain Res 440, 114268 (2023)
   PUBMED   36539163
  REMARK    GeneRIF: Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats.
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Samson,W.K., Salvemini,D. and Yosten,G.L.C.
  TITLE     Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise
  JOURNAL   Endocrinology 162 (8) (2021)
   PUBMED   34043767
  REMARK    GeneRIF: Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise.
            Review article
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Drott,C.J., Norman,D. and Espes,D.
  TITLE     CART decreases islet blood flow, but has no effect on total
            pancreatic blood flow and glucose tolerance in anesthetized rats
  JOURNAL   Peptides 135, 170431 (2021)
   PUBMED   33098940
  REMARK    GeneRIF: CART decreases islet blood flow, but has no effect on
            total pancreatic blood flow and glucose tolerance in anesthetized
            rats.
REFERENCE   5  (bases 1 to 834)
  AUTHORS   Walker,L.C., Hand,L.J., Letherby,B., Huckstep,K.L., Campbell,E.J.
            and Lawrence,A.J.
  TITLE     Cocaine and amphetamine regulated transcript (CART) signalling in
            the central nucleus of the amygdala modulates stress-induced
            alcohol seeking
  JOURNAL   Neuropsychopharmacology 46 (2), 325-333 (2021)
   PUBMED   32826981
REFERENCE   6  (bases 1 to 834)
  AUTHORS   Walder,K., Morris,C. and Ravussin,E.
  TITLE     A polymorphism in the gene encoding CART is not associated with
            obesity in Pima Indians
  JOURNAL   Int J Obes Relat Metab Disord 24 (4), 520-521 (2000)
   PUBMED   10805512
REFERENCE   7  (bases 1 to 834)
  AUTHORS   Echwald,S.M., Sorensen,T.I., Andersen,T., Hansen,C., Tommerup,N.
            and Pedersen,O.
  TITLE     Sequence variants in the human cocaine and amphetamine-regulated
            transcript (CART) gene in subjects with early onset obesity
  JOURNAL   Obes Res 7 (6), 532-536 (1999)
   PUBMED   10574510
REFERENCE   8  (bases 1 to 834)
  AUTHORS   Thim,L., Nielsen,P.F., Judge,M.E., Andersen,A.S., Diers,I.,
            Egel-Mitani,M. and Hastrup,S.
  TITLE     Purification and characterisation of a new hypothalamic satiety
            peptide, cocaine and amphetamine regulated transcript (CART),
            produced in yeast
  JOURNAL   FEBS Lett 428 (3), 263-268 (1998)
   PUBMED   9654146
REFERENCE   9  (bases 1 to 834)
  AUTHORS   Kristensen,P., Judge,M.E., Thim,L., Ribel,U., Christjansen,K.N.,
            Wulff,B.S., Clausen,J.T., Jensen,P.B., Madsen,O.D., Vrang,N.,
            Larsen,P.J. and Hastrup,S.
  TITLE     Hypothalamic CART is a new anorectic peptide regulated by leptin
  JOURNAL   Nature 393 (6680), 72-76 (1998)
   PUBMED   9590691
REFERENCE   10 (bases 1 to 834)
  AUTHORS   Douglass,J., McKinzie,A.A. and Couceyro,P.
  TITLE     PCR differential display identifies a rat brain mRNA that is
            transcriptionally regulated by cocaine and amphetamine
  JOURNAL   J Neurosci 15 (3 Pt 2), 2471-2481 (1995)
   PUBMED   7891182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_017110.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10071.1, SRR26360172.2203744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000002.1  32991058-32991235   c
            179-301             JAXUCZ010000002.1  32990546-32990668   c
            302-834             JAXUCZ010000002.1  32989221-32989753   c
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..834
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="CART prepropeptide"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
     exon            1..178
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..409
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cocaine and amphetamine regulated transcript;
                     cocaine- and amphetamine-regulated transcript protein"
                     /codon_start=1
                     /product="cocaine- and amphetamine-regulated transcript
                     protein isoform 1 precursor"
                     /protein_id="NP_058806.1"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
                     /translation="MESSRLRLLPVLGAALLLLLPLLGAGAQEDAELQPRALDIYSAV
                     DDASHEKELPRRQLRAPGAVLQIEALQEVLKKLKSKRIPIYEKKYGQVPMCDAGEQCA
                     VRKGARIGKLCDCPRGTSCNSFLLKCL"
     sig_peptide     20..100
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     101..406
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /product="Cocaine-and amphetamine-regulated transcript
                     protein. /id=PRO_0000004442"
                     /note="propagated from UniProtKB/Swiss-Prot (P49192.1)"
     misc_feature    140..142
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P49192.1); phosphorylation site"
     misc_feature    161..163
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P49192.1); phosphorylation site"
     misc_feature    218..406
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Cocaine and amphetamine regulated transcript
                     protein (CART); Region: CART; pfam06373"
                     /db_xref="CDD:461888"
     misc_feature    218..406
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Cocaine and amphetamine regulated transcript
                     protein (CART); Region: CART; pfam06373"
                     /db_xref="CDD:461888"
     exon            179..301
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     exon            302..834
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggaag tccagcacca tggagagctc ccgcctgcgg ctgctacccg tcctgggcgc
       61 cgccctactg ctgctgctac ctttgctggg tgccggtgcc caggaggatg ccgagctgca
      121 gccccgagcc ctggacatct actctgccgt ggatgatgcg tcccatgaga aggagctgcc
      181 aaggcggcaa cttcgggctc ccggcgctgt gttgcagatt gaagcgctgc aggaagtcct
      241 gaagaagctc aagagtaaac gcattccgat ctatgagaag aagtacggcc aagtccccat
      301 gtgtgacgct ggagagcagt gcgcagtgcg gaaaggggcc aggatcggga agctgtgtga
      361 ctgtccccga ggaacttctt gcaattcttt cctcttgaag tgcttgtgaa ggggtgacag
      421 cctccttcgg ttcccatatt tcctctttcc cctaaaggag cgctcttttg tccctggagc
      481 cgctttaaca acaataaagt ttgcgttccc cccagagagt ggatgggctc tttccctgct
      541 gcttcaaaat aaaagatttg atgttattgt gtgaaggaca ataccttgaa tggtgttggt
      601 atgtgtgcaa agtattcttc tctcgtttta tccacctgac acattcttgt gacctttctg
      661 ggaagaagag ggactttcgc tttaaaactg tatttttgta tgtggcgggt cacaatgaag
      721 attagaccta gttaattttg gcagatgaca tcataacccg gaaaacaaat caccccaaag
      781 caacacaaat ggaagcgtgt gcaaattaca cccaataaag catttttgat aatt
//
LOCUS       NM_001437879            1696 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus megakaryocyte-associated tyrosine kinase (Matk),
            transcript variant 2, mRNA.
ACCESSION   NM_001437879 XM_063264201
VERSION     NM_001437879.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Gunn,N.J., Gorman,M.A., Dobson,R.C., Parker,M.W. and Mulhern,T.D.
  TITLE     Purification, crystallization, small-angle X-ray scattering and
            preliminary X-ray diffraction analysis of the SH2 domain of the
            Csk-homologous kinase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 336-339
            (2011)
   PUBMED   21393838
  REMARK    GeneRIF: The CHK SH2 was expressed in Escherichia coli and the
            purified protein was characterized as monomeric by synchrotron
            small-angle X-ray scattering in-line with size-exclusion
            chromatography.
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Kuo,S.S., Moran,P., Gripp,J., Armanini,M., Phillips,H.S.,
            Goddard,A. and Caras,I.W.
  TITLE     Identification and characterization of Batk, a predominantly
            brain-specific non-receptor protein tyrosine kinase related to Csk
  JOURNAL   J Neurosci Res 38 (6), 705-715 (1994)
   PUBMED   7807586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063264201.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2424159.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000007.1  9113096-9113234     c
            140-199             JAXUCZ010000007.1  9112131-9112190     c
            200-313             JAXUCZ010000007.1  9111468-9111581     c
            314-429             JAXUCZ010000007.1  9111257-9111372     c
            430-616             JAXUCZ010000007.1  9110984-9111170     c
            617-710             JAXUCZ010000007.1  9110597-9110690     c
            711-776             JAXUCZ010000007.1  9109717-9109782     c
            777-876             JAXUCZ010000007.1  9109164-9109263     c
            877-961             JAXUCZ010000007.1  9108992-9109076     c
            962-1035            JAXUCZ010000007.1  9108841-9108914     c
            1036-1234           JAXUCZ010000007.1  9108550-9108748     c
            1235-1321           JAXUCZ010000007.1  9108173-9108259     c
            1322-1696           JAXUCZ010000007.1  9107711-9108085     c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1696
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
     exon            1..139
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            140..199
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="upstream in-frame stop codon"
     CDS             191..1561
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     megakaryocyte-associated tyrosine-protein kinase; protein
                     kinase BATK; tyrosine-protein kinase CTK;
                     megakaryocyte-associated tyrosine kinase (non-receptor
                     protein tyrosine kinase); non-receptor protein kinase
                     protein"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein kinase
                     isoform 2"
                     /protein_id="NP_001424808.1"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
                     /translation="MPTQRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKS
                     WYRAKHHSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGL
                     FLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAHYTRDKGAICTKLVKPKR
                     KQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA
                     QAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLRTRGRALVSTSQ
                     LLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSR
                     LPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRM
                     EPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKLGRELRSVGVAAPAGGQEAEGSAP
                     TRSQDP"
     misc_feature    215..391
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    215..391
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(236..238,242..244,251..253,263..265,320..325,
                     368..370,374..379)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212745"
     misc_feature    order(236..238,242..244,251..253,263..265,320..325,
                     368..370,374..379)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212745"
     misc_feature    419..679
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    419..679
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
                     /db_xref="CDD:472789"
     misc_feature    order(452..454,506..508,569..571,575..577)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(452..454,506..508,569..571,575..577)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(572..574,617..619)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    order(572..574,617..619)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    716..1480
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    716..1480
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(755..766,773..775,779..781,812..814,818..820,
                     899..901,944..955,1088..1090,1100..1105,1109..1111,
                     1139..1144)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(755..766,773..775,779..781,812..814,818..820,
                     899..901,944..955,1088..1090,1100..1105,1109..1111,
                     1139..1144)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     exon            200..313
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            314..429
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            430..616
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            617..710
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            711..776
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            777..876
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            877..961
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1035
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1234
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1321
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1696
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaggaccc gcaggggctc cgagccggtc ccctccatcc ttgccccaaa atgaggaagc
       61 cttgcaagtt gctcggagtt gagccaccag ggcgctcggc cggctggcag ggaccctcca
      121 ggggtcgcgc cctaagcagg tgaaccctca attctaagga gcttggcacc ccacgcctgc
      181 tgcagctaag atgccaacgc aacgctgggc ccctgggact caatgtatga ccaagtgcga
      241 gaactcacgc cccaagcccg gtgagctagc ctttcgaaag ggtgacatgg tgaccatctt
      301 ggaggcctgt gaggacaaga gctggtaccg agccaagcac cacagcagtg ggcaggaagg
      361 gctgctggcg gctgctgctc tgcgacagag ggaggccctt tccacagacc ccaagctcag
      421 cctcatgcca tggttccatg gcaagatttc cggtcaggaa gccatacagc agctgcagcc
      481 acccgaggat gggctgttcc tcgtgaggga atcggcccgt caccctggtg actatgtcct
      541 gtgtgtcagt ttcggccgtg atgtcatcca ctaccgtgtc ttgcatcgag atgggcacct
      601 caccattgat gaggcccact acaccaggga caagggcgcc atctgcacca agctggtgaa
      661 gcccaagagg aaacagggcg caaagtccgc agaggaagag ctcgccaagg ctggctggct
      721 gctagacctg cagcatctga ctctgggagc acagattgga gagggagagt ttggagccgt
      781 cctgcagggc gagtacttgg gacagaaggt ggccgtgaag aatataaagt gtgatgtgac
      841 agcccaggcc ttcctggatg agacggctgt gatgacaaag ctgcagcaca ggaacctagt
      901 gcgactcctg ggtgtgatcc tgcaccacgg cctgtacatt gtcatggaac acgtgagcaa
      961 gggcaacctg gtgaacttcc tgcgcacgcg gggccgtgcg cttgtgagca cctctcagct
     1021 cctgcagttt gctcttcacg ttgctgaagg catggagtac ctggagagca agaagctggt
     1081 acacagggac ctggctgctc gaaacatcct ggtctctgag gacttagtgg ccaaggtcag
     1141 tgactttggc ctagcaaagg cagagcttag gaaggggctg gactcaagtc ggctgccagt
     1201 caagtggaca gcacccgagg ctctcaaaaa tgggaggttc tccagcaagt cggatgtctg
     1261 gagttttggg gtgctactgt gggaagtctt ctcatatgga agagccccat accccaagat
     1321 gtcgctaaag gaggtttcag aggctgtgga gaagggttac cgcatggagc cccccgacag
     1381 ctgcccaggc cctgtgcata ccctcatggg cagctgctgg gaggctgagc cctcgcgcag
     1441 accaccgttc cgcaaaatag tggagaagct gggtcgtgag ctccgcagtg tgggcgtcgc
     1501 agcccccgcc gggggacagg aggctgaggg ctcagctccc acacggagcc aggacccctg
     1561 acccctgaac tggaaagcaa gaggacacag atgtagggtc acagggccag ggtgagccag
     1621 tgcacaggct ccggagcccc tgggatcccc gttactggga caccccataa agagtgattg
     1681 gaaggatttt gtacaa
//
LOCUS       NM_001437857            3669 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 7, mRNA.
ACCESSION   NM_001437857 XM_008770494
VERSION     NM_001437857.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3669)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3669)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3669)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3669)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3669)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3669)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3669)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3669)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3669)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3669)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770494.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.33848.1,
                                           SRR26643298.56235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1191           JAXUCZ010000015.1  3600390-3600458
            1192-1236           JAXUCZ010000015.1  3601575-3601619
            1237-1285           JAXUCZ010000015.1  3604223-3604271
            1286-1361           JAXUCZ010000015.1  3607566-3607641
            1362-1456           JAXUCZ010000015.1  3607997-3608091
            1457-1701           JAXUCZ010000015.1  3609598-3609842
            1702-3669           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3669
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1689
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 7 is encoded by transcript variant 7;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 7"
                     /protein_id="NP_001424786.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGST
                     ESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLV
                     EGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTS
                     QSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1288..1671
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1288..1671
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1191
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1236
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1285
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1361
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1456
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1701
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..3669
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca agccacagag caacaacaaa
     1141 aacagtctcg taagcccagc ccaagagccc gcgcccttgc agacggccat ggagccacaa
     1201 accaccgtgg tacataatgc tacagatggg atcaagggct ccacagagag ctgcaacacc
     1261 accacagaag acgaagatct caaagtgcga aaacaggaga tcattaagat cacagaacag
     1321 ctgatagaag ccatcaacaa tggggacttt gaggcctaca cgaagatttg tgacccaggc
     1381 ctcacttcct ttgagccaga agcccttggt aacctcgtgg aggggatgga tttccataag
     1441 ttttactttg agaatctcct gtccaagaac agcaagccta tccacaccac catcctaaac
     1501 ccacatgtcc atgtcatcgg cgaggacgca gcttgcatcg cctacatccg gctcacccag
     1561 tacatcgatg ggcagggtcg gcctcgcacc agtcagtcag aggagacccg ggtgtggcac
     1621 cgccgggatg gcaagtggct caatgtccac tatcactgct caggagcccc tgctgcaccg
     1681 ctgcagtgag ctcaggcaca ggggcattag gagattccag ctggaggctg aaccttcgaa
     1741 gtcagtgact ctggagggcc tgagtgacag ccgcggtcct gtccatttga ggtttaaaac
     1801 aattacatta caaagcggca gcagccaatg cacgcccctg catgcagccc tcccgcccgc
     1861 ccttcgtgtc tgtctctgct gtactgaggt gttttttaca tttaagaaaa aaaaaagaaa
     1921 ataagattgt tttaaaaaaa aatggaattc ataccatgat gcgttttaaa acaactgata
     1981 gcctttgggc ttgaagaagg caggagtttg tatgatgctc atccaggcgt gaacagaggg
     2041 ctcacccact ggctttgaag aggtgagctt ggcctcaggc ccccatggac tcggggggga
     2101 ccaggcaagg actcttgaca gagctttggt catggacaga gccatgctgt ggttgcagcc
     2161 ccggtggtga cctgatcact ccaggtctag gagtggactt cttcagaata tacattgaca
     2221 cctagtatga gaaagaagaa aactccatgg ctaacagacc tacttgggag agaacgcagc
     2281 gctcccagcc cgctgtggag gcaactgtga agcgtggcct cgggactgaa ggcctggact
     2341 ttgccgtacc gttccagtta gtgtagacag gaagagaatt ggtgctgcag aagtgtgtcc
     2401 gacacagagc cggtgtgaaa cctcgcgtta gtctgacacg cacttactca tccatttcta
     2461 taggatgcac aatgcacgtg ggcctgagac tgaggcctga tttctgcagg cgagaagggg
     2521 gtgggattgc tactttgttt cctgttggtt ttcctaatgt atcaaggaga gatccagaca
     2581 tcgttggcca gggctcctgt tgccactttc tgcagttgtg tttgtgtgcg gatctggacc
     2641 actttgtctt atattttcgt ggcggtggtc cccatgccga ccctctgcca agtgcccctg
     2701 cgggatggga ggagtgagat aagagttggt ggttgtttct atgcattctg gctgccctct
     2761 gggctgcctc ccttcttccc gtgctgcacg tccgtctctt tccctgagtt tgagattgaa
     2821 ccgactgctt gggtgagaag tgtcctcttt aatgaggctc tctaccgacc aactgaagta
     2881 tagacttttc tgctggacaa tctgcatggg catcaccccc tcacctgcat gtacccaaaa
     2941 aggggtccag agccaaggct cctgtagtca ttgtccctct ctgtgctcaa ggagttcctt
     3001 tccaggagga aaagatctgt accttaggca gataacagag aagacaatgg aggagcaatt
     3061 ggtcatagtc ttggttccct cccacccaac agctgcacac tatctgcatt ttggggggga
     3121 aggtgggttg acttcagctc tttggatgac cttcagggag gcacaggagc tgggaaaaga
     3181 tacagaacta cagactttgg aaccagctga gaagagaaca aactcatggg tgctggtgct
     3241 tgaatttagc caggctcctc aagcaccttg tgcatgcctc agaccctgga ccctagcccc
     3301 ttcctgccct gcagcctgca gtgccagcca acagatccct tcaccacagg gtttggtttt
     3361 gctggcttga agacaacaaa tggtcttaga gctcattgag acccatagct tcatatggct
     3421 gctccagccc cacttagcgt tcttactcca cttctggggc taatgtcagc atctatagac
     3481 aattaataga ctatttaaaa aaaaaaacca ccttttaaac aggaaatgaa aggcatttga
     3541 tgcagaactt ttgcatgacg acatagaaat aatttaaaaa tagtgtttgt tctgaatgtt
     3601 ggtagtccct tcatagcttt gttacaatga aaccttgaag atatttaata aaataacctt
     3661 taaacagtc
//
LOCUS       NM_001437831            3546 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            9, mRNA.
ACCESSION   NM_001437831
VERSION     NM_001437831.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3546)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3546)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 3546)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 3546)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 3546)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 3546)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 3546)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 3546)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 3546)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 3546)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2476.1,
                                           SRR26643294.2461.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               JAXUCZ010000001.1  105324149-105325054 c
            907-1378            JAXUCZ010000001.1  105320341-105320812 c
            1379-1528           JAXUCZ010000001.1  105319532-105319681 c
            1529-1623           JAXUCZ010000001.1  105319331-105319425 c
            1624-3546           JAXUCZ010000001.1  105317326-105319248 c
FEATURES             Location/Qualifiers
     source          1..3546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3546
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..906
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1378
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    958..960
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             973..1758
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 2 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 2"
                     /protein_id="NP_001424760.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGYVDCC"
     misc_feature    <1426..>1716
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <1426..>1716
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            1379..1528
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1623
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..3546
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggagg tgaggcttgt ccgggcctga agaaaaagct
      241 aatctcacac ttccggcact tccttaaatt cacggctgcc ttttccttat tctcagttta
      301 ctagacggaa ctgaaattca ggaagtccta ctagatctct tacccgagac tttcttgttg
      361 cggttcaacc catagtatca ttttttccca atattttgtg ttcagctttt tcccctgccc
      421 ctaaatgatc tcttcccgga tctctcctta gttttcttca ttagagacgg ctcctccctc
      481 cccccccaaa ccagactggt tgaaccggcc caacattttc gatgtactta ttgatgtgca
      541 gagaaggcac tcagagctcc cgtggctgga aagcggatag atagcaagct ctagagagaa
      601 tgaagtagag accatgacgg tggttggagg tgtggaggcc tgagggtgag aaggaaaaat
      661 ggtgagggaa acccaggcag aaggagagac aaagatacaa aaccgggcag ttggcaccta
      721 gccagatagt aagctacttc tggtgccagc tctacccacc ccccacccac ccccctttaa
      781 gtcaaggttt cacaaagttg cccagcctgg ctttgaccca gtcttcctgc ctcagcttcg
      841 gaagtaactg ggatcacagt ctttcaacac ttggcctggc tctgccattt aaaattgtga
      901 tcttggaggc tggaccagga gctgaccaca agccaagagt ctagaagtgc ttgggactga
      961 accaaggtcg tcatggcccc accaccacta ctgccagtgg ctgccagcac tccgatcctg
     1021 cacggcgagt ttggttccta cccagcccat ggccccaggt ttgccctcac cctcacgaca
     1081 caagccctac acatacagcg actgcgccca aagccagaag cccggccccg agatggtcta
     1141 gtccctctgg acgaggtctc aggctgtggc actctgcaga gccgtagccc cgaagacact
     1201 gcagcctact tctgcatcta cacctaccca cgtggccggc gtgggggccg gcgcagagct
     1261 actcgtacct tccgggccga cggggccgcc acttatgtgg agaatcgtgc agaggcccag
     1321 cgttgggcaa ctgctctcat gtgtctcctc cgaggagtgc ctctgtctgg ggaccaggaa
     1381 atcacccctg aattgctgcc ccggaagccc aggctgctcc tattggtcaa tccttttggg
     1441 gggcggggcc tggcctggca gcgctgtatg gaccacgtgg tgcccatgat ctctgaagct
     1501 gggctgtcct tcaacctcat acagacagaa cgacaaaacc atgcacgtga gctggtgcag
     1561 gggttgagcc tgagtgagtg ggaaggcatt gtcactgtgt ccggagatgg gctgctttat
     1621 gaggtgctga atgggctcct cgaccgccca gattgggaag acgctgtgcg gatgcccatt
     1681 ggtgtcctcc cctgtggttc gggcaatgca ctagctgggg cagttaacca tcatggcggg
     1741 tatgttgact gctgctgaga cagctaggga tacctgctaa agagagggat gagtctttgg
     1801 gacttcaggg tctgatatct tattatccag cacccactac cccttaccca agagcaagtt
     1861 ctgtggctgg cctgtagaat atcttcagtc agggatgctt atggggggct ccaggttatg
     1921 actcctggtg gcaggcattg ctgcgcctgc caccctttcc cctctgtgtc tcactcctca
     1981 ttgccctttc ccattgtgac acctctctct gattgtgaag gtttgagcaa actgttggtg
     2041 ttgacctgtt gctcaactgc tcgcttcttc tctgccgggg tggcagccat cctctggacc
     2101 tgctctctgt gacgctagcc tcaggatccc gctgtttttc cttcctgtca gttgcctggg
     2161 gattcttgtc agatgtggac attcacagcg agcgcttcag agccctgggc agtgctcgat
     2221 tcacactggg tgcagtgcta ggcctggcca cattgcatac ctaccgtgga cgtctctcct
     2281 acctccctgc taccacagaa ccagccttgc ccatcccagg ccatggtctg ccaagagcca
     2341 agtcagaact agccttggcc ccagccccag ccccagccgc cacccactca cctcttcatc
     2401 gatctgtgtc tgacctgccc ctgcctcttc cccagcctgc cctggcctcc cctggctccc
     2461 ctgagcccct gcctgacctg tccctcaatg gtggtggtcc agagctgact ggagactggg
     2521 ggggagctgg ggatgcacct ttgtccccag acccattgct gccttcatcc cccaacgctt
     2581 tcaaaacagc tcagctttca cccatcgccg aagggccctc agaaatgcca gcatcagggc
     2641 tgctgcctcc catccacaat gctccagaag cctctacctg gggcccagcg gaccacctgc
     2701 tccctcccct gggctctcca ctgccccaag actgggtgac aatagagggg gagtttgtac
     2761 tcatgttggc catcttgcca agccacctct gcgcagacct gatggcagcc ccacacgcgc
     2821 gttttgacga tggtgtggtg cacctgtgct gggtgcggag cggcatctca cgggccgcac
     2881 ttctacgaat tttgctggcc atggaacatg gaaaccactt cagcctgggc tgcccacatc
     2941 tgggctatgc tgcagcacgt gccttccgcc ttgagccact cacgcctcgt ggggtgctca
     3001 ctgtagatgg ggaattagta gagtatgggc caatacaggc acaggtgcat ccaagtctcg
     3061 ccacactgct cactgggcct gcaggtcaaa agcctcgagc ctgaatgagc ccaaagcatg
     3121 ccaagttgat gggaccagag ccccataggc taaggtctac cttttatagg tagaagtggg
     3181 gcctgaactc agaactgcaa gggtagagag tgctccagac cctcagttcc cagaggaccc
     3241 tagaggctcg agggtgggat ctgcctttct tgatgtccaa tgatggggcc tggaatgtat
     3301 gagctagcaa ggcttcttca gcttactgtc cagtcagggt ttcttcttgc ctatttcggt
     3361 gcctctactt gactggccaa tcagcccttg aggggcaggt tcccccaggt ggtccctaga
     3421 tttgcactaa tgttcccctg gccagttagg ggtgggatgt tctgtgtctt gtgtgtccct
     3481 gtccctagtc taaaaagcaa ttgaaaaggt ctatgcaata aaggtgttgc tttctctgga
     3541 cctgca
//
LOCUS       NM_001437852            3783 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 2, mRNA.
ACCESSION   NM_001437852 XM_008770488
VERSION     NM_001437852.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3783)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3783)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3783)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3783)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3783)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3783)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3783)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3783)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3783)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3783)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770488.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.487419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1191           JAXUCZ010000015.1  3600390-3600458
            1192-1236           JAXUCZ010000015.1  3601575-3601619
            1237-1285           JAXUCZ010000015.1  3604223-3604271
            1286-1399           JAXUCZ010000015.1  3605519-3605632
            1400-1475           JAXUCZ010000015.1  3607566-3607641
            1476-1570           JAXUCZ010000015.1  3607997-3608091
            1571-1815           JAXUCZ010000015.1  3609598-3609842
            1816-3783           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3783
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1803
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 2"
                     /protein_id="NP_001424781.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGST
                     ESCNTTTEDEDLKAAPLRTGNGSLVPEGRSPRDRTAPSAGMQPQPSLCSSAMRKQEII
                     KITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKP
                     IHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHY
                     HCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1402..1785
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1402..1785
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1191
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1236
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1285
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1399
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1475
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1570
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1815
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..3783
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca agccacagag caacaacaaa
     1141 aacagtctcg taagcccagc ccaagagccc gcgcccttgc agacggccat ggagccacaa
     1201 accaccgtgg tacataatgc tacagatggg atcaagggct ccacagagag ctgcaacacc
     1261 accacagaag acgaagatct caaagctgcc ccgctccgca ctgggaatgg cagcttggtg
     1321 cctgaaggac ggagcccccg ggacagaaca gccccctctg caggcatgca gccccagcct
     1381 tctctctgct cctcagccat gcgaaaacag gagatcatta agatcacaga acagctgata
     1441 gaagccatca acaatgggga ctttgaggcc tacacgaaga tttgtgaccc aggcctcact
     1501 tcctttgagc cagaagccct tggtaacctc gtggagggga tggatttcca taagttttac
     1561 tttgagaatc tcctgtccaa gaacagcaag cctatccaca ccaccatcct aaacccacat
     1621 gtccatgtca tcggcgagga cgcagcttgc atcgcctaca tccggctcac ccagtacatc
     1681 gatgggcagg gtcggcctcg caccagtcag tcagaggaga cccgggtgtg gcaccgccgg
     1741 gatggcaagt ggctcaatgt ccactatcac tgctcaggag cccctgctgc accgctgcag
     1801 tgagctcagg cacaggggca ttaggagatt ccagctggag gctgaacctt cgaagtcagt
     1861 gactctggag ggcctgagtg acagccgcgg tcctgtccat ttgaggttta aaacaattac
     1921 attacaaagc ggcagcagcc aatgcacgcc cctgcatgca gccctcccgc ccgcccttcg
     1981 tgtctgtctc tgctgtactg aggtgttttt tacatttaag aaaaaaaaaa gaaaataaga
     2041 ttgttttaaa aaaaaatgga attcatacca tgatgcgttt taaaacaact gatagccttt
     2101 gggcttgaag aaggcaggag tttgtatgat gctcatccag gcgtgaacag agggctcacc
     2161 cactggcttt gaagaggtga gcttggcctc aggcccccat ggactcgggg gggaccaggc
     2221 aaggactctt gacagagctt tggtcatgga cagagccatg ctgtggttgc agccccggtg
     2281 gtgacctgat cactccaggt ctaggagtgg acttcttcag aatatacatt gacacctagt
     2341 atgagaaaga agaaaactcc atggctaaca gacctacttg ggagagaacg cagcgctccc
     2401 agcccgctgt ggaggcaact gtgaagcgtg gcctcgggac tgaaggcctg gactttgccg
     2461 taccgttcca gttagtgtag acaggaagag aattggtgct gcagaagtgt gtccgacaca
     2521 gagccggtgt gaaacctcgc gttagtctga cacgcactta ctcatccatt tctataggat
     2581 gcacaatgca cgtgggcctg agactgaggc ctgatttctg caggcgagaa gggggtggga
     2641 ttgctacttt gtttcctgtt ggttttccta atgtatcaag gagagatcca gacatcgttg
     2701 gccagggctc ctgttgccac tttctgcagt tgtgtttgtg tgcggatctg gaccactttg
     2761 tcttatattt tcgtggcggt ggtccccatg ccgaccctct gccaagtgcc cctgcgggat
     2821 gggaggagtg agataagagt tggtggttgt ttctatgcat tctggctgcc ctctgggctg
     2881 cctcccttct tcccgtgctg cacgtccgtc tctttccctg agtttgagat tgaaccgact
     2941 gcttgggtga gaagtgtcct ctttaatgag gctctctacc gaccaactga agtatagact
     3001 tttctgctgg acaatctgca tgggcatcac cccctcacct gcatgtaccc aaaaaggggt
     3061 ccagagccaa ggctcctgta gtcattgtcc ctctctgtgc tcaaggagtt cctttccagg
     3121 aggaaaagat ctgtacctta ggcagataac agagaagaca atggaggagc aattggtcat
     3181 agtcttggtt ccctcccacc caacagctgc acactatctg cattttgggg gggaaggtgg
     3241 gttgacttca gctctttgga tgaccttcag ggaggcacag gagctgggaa aagatacaga
     3301 actacagact ttggaaccag ctgagaagag aacaaactca tgggtgctgg tgcttgaatt
     3361 tagccaggct cctcaagcac cttgtgcatg cctcagaccc tggaccctag ccccttcctg
     3421 ccctgcagcc tgcagtgcca gccaacagat cccttcacca cagggtttgg ttttgctggc
     3481 ttgaagacaa caaatggtct tagagctcat tgagacccat agcttcatat ggctgctcca
     3541 gccccactta gcgttcttac tccacttctg gggctaatgt cagcatctat agacaattaa
     3601 tagactattt aaaaaaaaaa accacctttt aaacaggaaa tgaaaggcat ttgatgcaga
     3661 acttttgcat gacgacatag aaataattta aaaatagtgt ttgttctgaa tgttggtagt
     3721 cccttcatag ctttgttaca atgaaacctt gaagatattt aataaaataa cctttaaaca
     3781 gtc
//
LOCUS       NM_001437842            4002 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 11, mRNA.
ACCESSION   NM_001437842 XM_039101703
VERSION     NM_001437842.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039101703.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.69318.1,
                                           SRR26360186.562340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1449           JAXUCZ010000002.1  217916935-217916983
            1450-1525           JAXUCZ010000002.1  217946550-217946625
            1526-1620           JAXUCZ010000002.1  217955065-217955159
            1621-1849           JAXUCZ010000002.1  217957098-217957326
            1850-4002           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4002
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1853
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 11 is encoded by transcript variant 11;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 11"
                     /protein_id="NP_001424771.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESS
                     NTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGM
                     DFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSE
                     ETRVWHRRDGKWQNIHFHRSGSPTVPIN"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1452..1835
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1452..1835
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1449
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1525
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1620
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1849
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..4002
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag gagtcaactg agagctcaaa taccaccatt gaggatgaag
     1441 acgtgaaagc acgaaagcaa gagatcatca aagtcactga gcagctgatt gaagctatca
     1501 acaatgggga cttcgaggct tacacgaaaa tctgtgatcc aggcctcact gcctttgaac
     1561 ccgaagcatt gggcaactta gtggaaggga tggactttca cagattctac tttgaaaatg
     1621 ctttgcccaa aatcaataaa ccaatccaca ctatcatcct gaaccctcac gtacacctgg
     1681 taggggatga tgcagcctgc atagcataca ttcggctcac acagtacatg gatggaaatg
     1741 gaatgccaaa gacaatgcag tcagaagaga ctcgagtgtg gcaccgccgt gatgggaagt
     1801 ggcagaatat tcactttcat cgttcggggt ccccaacagt ccccatcaac taattgtcaa
     1861 cagtgccacg tcttcattct gtcctcaagg cacctggcgg ggtgatcctg ggacatcctc
     1921 tcctcttcat gcatgtttct gagtgcatga agttgtgaag gttctacgtg taatgcatat
     1981 gtgacacgtc atcttaccat gtgacacgcc atcttaccat gtattccttc ctgtacattg
     2041 tttacactcc agctactgga cggatgttcc atgcaaacgt cagttactgc tggcaaacta
     2101 aagagggagc tccgacaaga aaactccgca atactccaag ttcagctgat ccatcaggtt
     2161 tctctgtgga tgccaagatt caaaagactt cataaaatta ctgttcaatg aatgacagtg
     2221 tgtaagagga aaggaaatct ttcaagaatg ctgccattaa tctatttggg cttctcattg
     2281 ggattttggg gttgattttt ttttcatttt ttaaggcaaa tatatatata tatatatata
     2341 tatatatata tatatatata tatatatata tgccttcagt tcctggtaga aatgaatgga
     2401 tgccttttct ctgaaagtgt tggtgttgga taaatggatg gctatgtgag ccaagtcctg
     2461 ggtgattgta ggagcaagaa tcgtttgctg ttctaccatc aaagccatgt tgatttgggt
     2521 cgagctctgt atactggaaa aattcacatc attttctagt ttgattgctt tcagataggc
     2581 acagttctgg tgaatgcttg gcactgatct tggtttttct ttcctaaatc tgtgttctgt
     2641 tttcattata tactatttgc tcctttcctt tgtatttgtt ttcttttccc actcttttct
     2701 ttatctttct ctctcccact ttctttcttt tttatgtttt cctttctata gctgatagtg
     2761 tgtaaaaaca gtaacatttg catatgaagt taaaataaaa atcaaggtct tctagaagct
     2821 aaaactagca cttccggtct ctcacggggc tgtggagttg ttagaagatt taaataaata
     2881 cttaaataag agaggaatga attcagctta ggttaccact tgtgcatagg tatccttgct
     2941 ctgttgaaag tgttggaatt gttgagactt aagctaacag cagtaagagc ctgcttacac
     3001 agtcctggtt ctccccaact agatattgaa gaccaagtgg agcctgacca gggttgcatg
     3061 cagagcactt gttttggacc ttccagacta ggaggcattt actgcctcac tttcactagc
     3121 tagccacagg aagagtgttc tccatcctcc tagaggttga acttgacctt cgtgactagt
     3181 gcagttctag cttctctctt gagtcacagt agcatcctga tgccaggagt taggcttttg
     3241 tccagattaa aacaacgagg aaaaggaaat gccccagttt tctttccgtt tcccatttct
     3301 tctttgtcga ttcggtccct gggagactgt ttctccgcgc tgaactgctt tatggtgcat
     3361 ggaatctcca tcagcgtact tctaccctag ccactcacac tccttagaag ctgattttta
     3421 aagcagaagc aaggaagcaa aagtaaaaca ctcccttccc ctctttttcc tcatttcacc
     3481 ttttggtgtt gattgctaat cactttagat atattgttgc tagtgaatgt atgatagatg
     3541 ggttgaagct tttctgataa ttagcacatg atttaaaaca atatatattt aaaacaaata
     3601 tatacagtac atgtattgag ccgtgttaac ctgccaatga gatctgtgaa aaacgtaatg
     3661 gcctcacttt tccctttgaa tttcttttac ctttctgtga agcagctctg cgtggcatac
     3721 atgtatttaa aaacacaaat agtggtagaa tgggtttttt ttttacactt ttaacttagc
     3781 atgtggtgtt gaagtattac catagatcca gtttgtcttc tgcactaaga tgtgaggaaa
     3841 tcgtgatttg ttctctccag cacagtggaa ttacaccttc atcatcttct attgttttga
     3901 aaacactgca gtttaccatg ggacactgta tataattctt gccgtaatgg taaatgacaa
     3961 attgatatat ttaagagtta ataaatttgt gatttctgct ga
//
LOCUS       NM_001437875            1193 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus growth hormone receptor (Ghr), transcript variant
            4, mRNA.
ACCESSION   NM_001437875 XM_039101771
VERSION     NM_001437875.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Klammt,J., Shen,S., Kiess,W., Kratzsch,J., Stobbe,H., Vogel,M.,
            Luo,F. and Pfaffle,R.
  TITLE     Clinical and biochemical consequences of an intragenic growth
            hormone receptor (GHR) deletion in a large Chinese pedigree
  JOURNAL   Clin Endocrinol (Oxf) 82 (3), 453-461 (2015)
   PUBMED   25196842
REFERENCE   2  (bases 1 to 1193)
  AUTHORS   Deng,H.Z., Deng,H., Cen,C.Q., Chen,K.Y. and Du,M.L.
  TITLE     Post-receptor crosstalk between growth hormone and insulin signal
            in rats born small for gestational age with catch-up growth
  JOURNAL   PLoS One 9 (6), e100459 (2014)
   PUBMED   24963636
  REMARK    GeneRIF: receptor crosstalk between growth hormone and insulin
            signal in rats born small for gestational age with catch-up growth
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1193)
  AUTHORS   Claessen,K.M., Kloppenburg,M., Kroon,H.M., Bijsterbosch,J.,
            Pereira,A.M., Romijn,J.A., van der Straaten,T., Nelissen,R.G.,
            Hofman,A., Uitterlinden,A.G., Duijnisveld,B.J., Lakenberg,N.,
            Beekman,M., van Meurs,J.B., Slagboom,P.E., Biermasz,N.R. and
            Meulenbelt,I.
  TITLE     Relationship between the functional exon 3 deleted growth hormone
            receptor polymorphism and symptomatic osteoarthritis in women
  JOURNAL   Ann Rheum Dis 73 (2), 433-436 (2014)
   PUBMED   23740230
REFERENCE   4  (bases 1 to 1193)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1193)
  AUTHORS   Enhamre,E., Carlsson,A., Gronbladh,A., Watanabe,H., Hallberg,M. and
            Nyberg,F.
  TITLE     The expression of growth hormone receptor gene transcript in the
            prefrontal cortex is affected in male mice with diabetes-induced
            learning impairments
  JOURNAL   Neurosci Lett 523 (1), 82-86 (2012)
   PUBMED   22750159
REFERENCE   6  (bases 1 to 1193)
  AUTHORS   Frick,G.P. and Goodman,H.M.
  TITLE     Characterization of the short isoform of the growth hormone
            receptor synthesized by rat adipocytes
  JOURNAL   Endocrinology 131 (6), 3083-3090 (1992)
   PUBMED   1446642
REFERENCE   7  (bases 1 to 1193)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 1193)
  AUTHORS   Godowski,P.J., Leung,D.W., Meacham,L.R., Galgani,J.P., Hellmiss,R.,
            Keret,R., Rotwein,P.S., Parks,J.S., Laron,Z. and Wood,W.I.
  TITLE     Characterization of the human growth hormone receptor gene and
            demonstration of a partial gene deletion in two patients with
            Laron-type dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8083-8087 (1989)
   PUBMED   2813379
REFERENCE   9  (bases 1 to 1193)
  AUTHORS   Baumbach,W.R., Horner,D.L. and Logan,J.S.
  TITLE     The growth hormone-binding protein in rat serum is an alternatively
            spliced form of the rat growth hormone receptor
  JOURNAL   Genes Dev 3 (8), 1199-1205 (1989)
   PUBMED   2792761
REFERENCE   10 (bases 1 to 1193)
  AUTHORS   Mathews,L.S., Enberg,B. and Norstedt,G.
  TITLE     Regulation of rat growth hormone receptor gene expression
  JOURNAL   J Biol Chem 264 (17), 9905-9910 (1989)
   PUBMED   2722883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039101771.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216498.1, BC127501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000002.1  54532095-54532325   c
            232-310             JAXUCZ010000002.1  54418526-54418604   c
            311-376             JAXUCZ010000002.1  54351981-54352046   c
            377-506             JAXUCZ010000002.1  54304431-54304560   c
            507-679             JAXUCZ010000002.1  54298368-54298540   c
            680-858             JAXUCZ010000002.1  54285767-54285945   c
            859-1027            JAXUCZ010000002.1  54279713-54279881   c
            1028-1193           JAXUCZ010000002.1  54279248-54279413   c
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1193
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
     exon            1..231
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..117
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="upstream in-frame stop codon"
     exon            232..310
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1080
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; growth hormone receptor/binding protein; GH
                     receptor; somatotropin receptor; growth hormone receptor
                     variant d5-6"
                     /codon_start=1
                     /product="growth hormone receptor isoform 2 precursor"
                     /protein_id="NP_001424804.1"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
                     /translation="MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLR
                     ESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECP
                     DYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLL
                     NISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLY
                     SLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEGPKFNSQHPHQEID
                     NHL"
     sig_peptide     241..312
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    385..621
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    385..621
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    583..585
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    685..990
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    685..990
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(685..687,904..906,955..957)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(685..687,904..906,955..957)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    706..708
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    721..723
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    838..840
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    958..972
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: WSXWS motif.
                     /evidence=ECO:0000250|UniProtKB:P10912"
     misc_feature    order(958..963,967..972)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(958..963,967..972)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     exon            311..376
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            377..506
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            507..679
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            680..858
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1027
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1193
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagcccac gagctgccaa gcagggcgca gccatgggaa gaggaggcgg tctagggagc
       61 ggcggcactg gcagaagcgg ctgttacagc ggcggtggcg gcgacggctg ttgctgagcc
      121 ccggcagccg cgaggacccc gggctggggc cacgcgggcc tgaggcctcg gctccagcag
      181 cccccaagcg gacgcgaacc cgcgctctgt ctcccaaggc gaagctccga ggtctcaggt
      241 atggatcttt ggcgggtgtt cttaaccctg gcactggcag tctccagcga catgtttcct
      301 ggaagtgggg ctacaccagc tactcttggc aaagcttccc cggttctgca aagaattaat
      361 ccaagcctga gggaaagttc ctctggaaag cctcgattca ccaagtgtcg ttcccctgaa
      421 ctggagacct tttcatgcta ctggacagaa ggggatgatc ataatttaaa ggtcccggga
      481 tctattcagc tatactatgc tagaagaatt gctcatgaat ggaccccgga atggaaagaa
      541 tgccctgatt atgtctctgc tggagcaaac agctgttact tcaactcatc gtatacctcc
      601 atttggatac cctactgcat taagcttact acaaatggtg atttgttgga cgaaaagtgt
      661 ttcactgttg atgaaatagt gcaacctgat ccgcccattg gcctcaactg gactttacta
      721 aacatcagtt tgcctgggat ccgtggagat atccaagtga gttggcagcc accgcccagt
      781 gccgatgttc tgaagggatg gataattctg gagtatgaaa ttcagtacaa agaagtaaat
      841 gaaacaaaat ggaaaacgat gagcccgata tggtcaacat cagtcccact gtactcactg
      901 agactggata aagagcacga agtgcgtgtg agatccagac aacggagctt cgaaaagtac
      961 agcgagttca gtgaagtact ccgtgtaacg tttcctcaga tggacacact ggcagcatgt
     1021 gaagaaggac ccaagttcaa ttcccagcac ccacatcaag agattgacaa ccacctgtaa
     1081 caccagctcc agaggatctg ccatccctag ccttgcgggc acctgcattc atatgcacat
     1141 acatgcatac acataattaa aattaataaa ataaaatttt aaaaatatca aaa
//
LOCUS       NM_001437824            2639 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            3, mRNA.
ACCESSION   NM_001437824 XM_008759383
VERSION     NM_001437824.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008759383.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.2162.1,
                                           SRR26643295.2316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000001.1  105324846-105325054 c
            210-280             JAXUCZ010000001.1  105324149-105324219 c
            281-752             JAXUCZ010000001.1  105320341-105320812 c
            753-902             JAXUCZ010000001.1  105319532-105319681 c
            903-997             JAXUCZ010000001.1  105319331-105319425 c
            998-1113            JAXUCZ010000001.1  105319133-105319248 c
            1114-2639           JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2639
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..209
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..280
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..752
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    332..334
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             347..2197
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424753.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <800..2167
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <800..2167
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            753..902
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..997
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1113
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2639
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggagc ttcggaagta actgggatca cagtctttca
      241 acacttggcc tggctctgcc atttaaaatt gtgatcttgg aggctggacc aggagctgac
      301 cacaagccaa gagtctagaa gtgcttggga ctgaaccaag gtcgtcatgg ccccaccacc
      361 actactgcca gtggctgcca gcactccgat cctgcacggc gagtttggtt cctacccagc
      421 ccatggcccc aggtttgccc tcaccctcac gacacaagcc ctacacatac agcgactgcg
      481 cccaaagcca gaagcccggc cccgagatgg tctagtccct ctggacgagg tctcaggctg
      541 tggcactctg cagagccgta gccccgaaga cactgcagcc tacttctgca tctacaccta
      601 cccacgtggc cggcgtgggg gccggcgcag agctactcgt accttccggg ccgacggggc
      661 cgccacttat gtggagaatc gtgcagaggc ccagcgttgg gcaactgctc tcatgtgtct
      721 cctccgagga gtgcctctgt ctggggacca ggaaatcacc cctgaattgc tgccccggaa
      781 gcccaggctg ctcctattgg tcaatccttt tggggggcgg ggcctggcct ggcagcgctg
      841 tatggaccac gtggtgccca tgatctctga agctgggctg tccttcaacc tcatacagac
      901 agaacgacaa aaccatgcac gtgagctggt gcaggggttg agcctgagtg agtgggaagg
      961 cattgtcact gtgtccggag atgggctgct ttatgaggtg ctgaatgggc tcctcgaccg
     1021 cccagattgg gaagacgctg tgcggatgcc cattggtgtc ctcccctgtg gttcgggcaa
     1081 tgcactagct ggggcagtta accatcatgg cgggtttgag caaactgttg gtgttgacct
     1141 gttgctcaac tgctcgcttc ttctctgccg gggtggcagc catcctctgg acctgctctc
     1201 tgtgacgcta gcctcaggat cccgctgttt ttccttcctg tcagttgcct ggggattctt
     1261 gtcagatgtg gacattcaca gcgagcgctt cagagccctg ggcagtgctc gattcacact
     1321 gggtgcagtg ctaggcctgg ccacattgca tacctaccgt ggacgtctct cctacctccc
     1381 tgctaccaca gaaccagcct tgcccatccc aggccatggt ctgccaagag ccaagtcaga
     1441 actagccttg gccccagccc cagccccagc cgccacccac tcacctcttc atcgatctgt
     1501 gtctgacctg cccctgcctc ttccccagcc tgccctggcc tcccctggct cccctgagcc
     1561 cctgcctgac ctgtccctca atggtggtgg tccagagctg actggagact gggggggagc
     1621 tggggatgca cctttgtccc cagacccatt gctgccttca tcccccaacg ctttcaaaac
     1681 agctcagctt tcacccatcg ccgaagggcc ctcagaaatg ccagcatcag ggctgctgcc
     1741 tcccatccac aatgctccag aagcctctac ctggggccca gcggaccacc tgctccctcc
     1801 cctgggctct ccactgcccc aagactgggt gacaatagag ggggagtttg tactcatgtt
     1861 ggccatcttg ccaagccacc tctgcgcaga cctgatggca gccccacacg cgcgttttga
     1921 cgatggtgtg gtgcacctgt gctgggtgcg gagcggcatc tcacgggccg cacttctacg
     1981 aattttgctg gccatggaac atggaaacca cttcagcctg ggctgcccac atctgggcta
     2041 tgctgcagca cgtgccttcc gccttgagcc actcacgcct cgtggggtgc tcactgtaga
     2101 tggggaatta gtagagtatg ggccaataca ggcacaggtg catccaagtc tcgccacact
     2161 gctcactggg cctgcaggtc aaaagcctcg agcctgaatg agcccaaagc atgccaagtt
     2221 gatgggacca gagccccata ggctaaggtc taccttttat aggtagaagt ggggcctgaa
     2281 ctcagaactg caagggtaga gagtgctcca gaccctcagt tcccagagga ccctagaggc
     2341 tcgagggtgg gatctgcctt tcttgatgtc caatgatggg gcctggaatg tatgagctag
     2401 caaggcttct tcagcttact gtccagtcag ggtttcttct tgcctatttc ggtgcctcta
     2461 cttgactggc caatcagccc ttgaggggca ggttccccca ggtggtccct agatttgcac
     2521 taatgttccc ctggccagtt aggggtggga tgttctgtgt cttgtgtgtc cctgtcccta
     2581 gtctaaaaag caattgaaaa ggtctatgca ataaaggtgt tgctttctct ggacctgca
//
LOCUS       NM_001108559            2259 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus pre-mRNA processing factor 3 (Prpf3), transcript
            variant 1, mRNA.
ACCESSION   NM_001108559 XM_001057756 XM_342295
VERSION     NM_001108559.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Long,S.W., Ooi,J.Y., Yau,P.M. and Jones,P.L.
  TITLE     A brain-derived MeCP2 complex supports a role for MeCP2 in RNA
            processing
  JOURNAL   Biosci Rep 31 (5), 333-343 (2011)
   PUBMED   21070191
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J.,
            Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.
  TITLE     The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control
            reversible ubiquitination at the spliceosome
  JOURNAL   Genes Dev 24 (13), 1434-1447 (2010)
   PUBMED   20595234
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   8  (bases 1 to 2259)
  AUTHORS   Schaffert,N., Hossbach,M., Heintzmann,R., Achsel,T. and Luhrmann,R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   9  (bases 1 to 2259)
  AUTHORS   Chakarova,C.F., Hims,M.M., Bolz,H., Abu-Safieh,L., Patel,R.J.,
            Papaioannou,M.G., Inglehearn,C.F., Keen,T.J., Willis,C.,
            Moore,A.T., Rosenberg,T., Webster,A.R., Bird,A.C., Gal,A., Hunt,D.,
            Vithana,E.N. and Bhattacharya,S.S.
  TITLE     Mutations in HPRP3, a third member of pre-mRNA splicing factor
            genes, implicated in autosomal dominant retinitis pigmentosa
  JOURNAL   Hum Mol Genet 11 (1), 87-92 (2002)
   PUBMED   11773002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001108559.1.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000002.1  186092318-186092355 c
            39-231              JAXUCZ010000002.1  186089948-186090140 c
            232-362             JAXUCZ010000002.1  186087902-186088032 c
            363-509             JAXUCZ010000002.1  186085129-186085275 c
            510-593             JAXUCZ010000002.1  186083966-186084049 c
            594-814             JAXUCZ010000002.1  186083585-186083805 c
            815-1121            JAXUCZ010000002.1  186081114-186081420 c
            1122-1288           JAXUCZ010000002.1  186080368-186080534 c
            1289-1368           JAXUCZ010000002.1  186077517-186077596 c
            1369-1512           JAXUCZ010000002.1  186074038-186074181 c
            1513-1612           JAXUCZ010000002.1  186073378-186073477 c
            1613-1726           JAXUCZ010000002.1  186073061-186073174 c
            1727-1845           JAXUCZ010000002.1  186071606-186071724 c
            1846-1929           JAXUCZ010000002.1  186071281-186071364 c
            1930-2259           JAXUCZ010000002.1  186067980-186068309 c
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2259
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
     exon            1..38
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            39..231
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Prpf3"
                     /note="upstream in-frame stop codon"
     CDS             87..2000
                     /gene="Prpf3"
                     /note="isoform 1 is encoded by transcript variant 1; U4/U6
                     small nuclear ribonucleoprotein Prp3; PRP3 pre-mRNA
                     processing factor 3 homolog"
                     /codon_start=1
                     /product="U4/U6 small nuclear ribonucleoprotein Prp3
                     isoform 1"
                     /protein_id="NP_001102029.1"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
                     /translation="MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDK
                     KKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEIS
                     KESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQL
                     SFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLA
                     LKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTH
                     RMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGK
                     FEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDS
                     YIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR
                     QTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQ
                     KAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQ
                     LYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDGHSQRPELWR
                     DEVQTVPYREHGA"
     misc_feature    93..305
                     /gene="Prpf3"
                     /note="domain in splicing factors; Region: PWI;
                     smart00311"
                     /db_xref="CDD:214609"
     misc_feature    93..305
                     /gene="Prpf3"
                     /note="domain in splicing factors; Region: PWI;
                     smart00311"
                     /db_xref="CDD:214609"
     misc_feature    1008..1649
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3 (PRP3); Region: PRP3;
                     pfam08572"
                     /db_xref="CDD:462524"
     misc_feature    1008..1649
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3 (PRP3); Region: PRP3;
                     pfam08572"
                     /db_xref="CDD:462524"
     misc_feature    1707..>1931
                     /gene="Prpf3"
                     /note="C-terminal domain of U4/U6 small nuclear
                     ribonucleoprotein Prp3; Region: Prp3_C; cd24162"
                     /db_xref="CDD:467813"
     misc_feature    1707..>1931
                     /gene="Prpf3"
                     /note="C-terminal domain of U4/U6 small nuclear
                     ribonucleoprotein Prp3; Region: Prp3_C; cd24162"
                     /db_xref="CDD:467813"
     exon            232..362
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..509
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..593
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..814
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1121
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1288
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1368
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1512
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1612
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1726
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1845
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1929
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2259
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgttcggg ctccgtctca ggggctgaag tttgtgaggt gtagtacttt gtccgatttg
       61 agctcttagt ctctgtttcc tccaaaatgg cactgtctaa gcgggaactg gatgagctga
      121 aaccatggat agagaagaca gtgaagagag tgctgggttt ctcagagccc acggtggtca
      181 cagcggcatt gaactgtgtg gggaagggca tggacaaaaa gaaggcggct gatcacctga
      241 aaccttttct tgatgactcc actctccgat ttgtggataa gttgtttgaa gctgtggagg
      301 aaggccggag ctcaagacac tccaagtcta gcagtgacag aagcaggaaa cgagagttaa
      361 aggaggtgtt tggtgatgac tctgagatct caaaggaatc atcaggggta aagaagcggc
      421 gaataccccg ttttgaggag gtagaagagg aaccagaggt gatccctgga cctccgtcag
      481 aaagccctgg catgctaacg aagctccaga tcaaacagat gatggaggca gcaacgagac
      541 aaatcgagga aaggaaaaag cagctgagct tcatcagccc ccctgcacct cagccaaaga
      601 caccttcttc ttcccaacca gagcgacttc caattggcaa cactattcag ccctcccagg
      661 ccgctacctt tatgaatgat gccattgaga aggcaaggaa agccgctgaa ctacaagccc
      721 gaatccaggc ccagctggct ttgaagccag ggcttattgg caatgccaac atggtgggcc
      781 tagctaatct ccatgccatg ggcatagctc caccgaaagt cgagttaaaa gatcagacga
      841 agcccacccc actgatcctg gatgagcaag gccgcactgt ggatgccaca ggcaaggagg
      901 tggagctcac acaccgcatg cccaccctga aggcaaacat tcgagctgtg aagagggaac
      961 agttcaaaca gcaactaaaa gaaaagccat cagaagacat ggaatctaat accttttttg
     1021 accccagagt ctcaattgcc ccttcccagc gtcaaagacg cacttttaaa ttccatgaca
     1081 agggcaaatt tgagaagatt gctcaacgat tacggacaaa ggctcagttg gaaaagctgc
     1141 aagcagagat ttcacaggct gctagaaaaa caggcattca tacgtcgact agacttgccc
     1201 tcattgctcc taaaaaagag ctgaaggaag gcgacatccc tgaaattgag tggtgggact
     1261 cctacatcat tcccaatggc tttgacctta cagaggaaaa tcccaagaga gaagattatt
     1321 ttggaatcac aaatcttgtt gaacatccag cccagcttaa ccctccagtt gacaatgaca
     1381 caccagttac cctgggtgtg tatcttacaa agaaggagca gaagaaactt cggaggcaaa
     1441 caaggaggga ggcacagaag gagctacagg agaaagtcag gctaggcctg acacctcctc
     1501 cagagcccaa agtgaggatc tccaatttaa tgcgagtatt aggaacagaa gcagttcaag
     1561 accctacaaa ggtagaagcc cacgtcagag ctcagatggc aaagagacag aaagcgcacg
     1621 aagaggccaa cgctgcccga aaacttacag cagaacagag aaaggtcaag aaagttaaaa
     1681 agcttaaaga agacatttca cagggggtgc acatatctgt gtatagagtt cgaaatttga
     1741 gcaacccagc caagaagttc aagatcgagg ccaatgctgg gcagctgtac ctgacggggg
     1801 tggtagtgct gcacaaggat gtcaacgtgg tggtcgtgga agggggcccc aaagcccaga
     1861 agaaatttaa gcgtctcatg ctacatcgga taaagtggga tgagcagacg tctaacacga
     1921 agggagatgg gcacagccaa agaccggagc tttggagaga tgaagttcaa acagtgccct
     1981 acagagaaca tggcgcgtga gcatttcaag aagcacgggg ctgagcacta ctgggacctt
     2041 gccctgagtg aatctgtgct ggagtccacc gactgagacg actgctagcc ttgtgtcttc
     2101 ttctcactct gcttcccaac cttacccaac tgtgcgtgtg atctcagaac cgtgccaggc
     2161 tgatactggg gcaaagagac taccaagttc acccagtcag cctggtgcta cccttcctcc
     2221 tgtatgtgca tatgattaaa gagttatttt taaaattag
//
LOCUS       NM_001437880            1862 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus megakaryocyte-associated tyrosine kinase (Matk),
            transcript variant 4, mRNA.
ACCESSION   NM_001437880 XM_063264200
VERSION     NM_001437880.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Gunn,N.J., Gorman,M.A., Dobson,R.C., Parker,M.W. and Mulhern,T.D.
  TITLE     Purification, crystallization, small-angle X-ray scattering and
            preliminary X-ray diffraction analysis of the SH2 domain of the
            Csk-homologous kinase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 336-339
            (2011)
   PUBMED   21393838
  REMARK    GeneRIF: The CHK SH2 was expressed in Escherichia coli and the
            purified protein was characterized as monomeric by synchrotron
            small-angle X-ray scattering in-line with size-exclusion
            chromatography.
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Kuo,S.S., Moran,P., Gripp,J., Armanini,M., Phillips,H.S.,
            Goddard,A. and Caras,I.W.
  TITLE     Identification and characterization of Batk, a predominantly
            brain-specific non-receptor protein tyrosine kinase related to Csk
  JOURNAL   J Neurosci Res 38 (6), 705-715 (1994)
   PUBMED   7807586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063264200.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.37820.1,
                                           SRR26360176.2256034.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000007.1  9116388-9116659     c
            273-332             JAXUCZ010000007.1  9112131-9112190     c
            333-446             JAXUCZ010000007.1  9111468-9111581     c
            447-562             JAXUCZ010000007.1  9111257-9111372     c
            563-782             JAXUCZ010000007.1  9110951-9111170     c
            783-876             JAXUCZ010000007.1  9110597-9110690     c
            877-942             JAXUCZ010000007.1  9109717-9109782     c
            943-1042            JAXUCZ010000007.1  9109164-9109263     c
            1043-1127           JAXUCZ010000007.1  9108992-9109076     c
            1128-1201           JAXUCZ010000007.1  9108841-9108914     c
            1202-1400           JAXUCZ010000007.1  9108550-9108748     c
            1401-1487           JAXUCZ010000007.1  9108173-9108259     c
            1488-1862           JAXUCZ010000007.1  9107711-9108085     c
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1862
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
     exon            1..272
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            273..332
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    288..290
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="upstream in-frame stop codon"
     CDS             324..1727
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     megakaryocyte-associated tyrosine-protein kinase; protein
                     kinase BATK; tyrosine-protein kinase CTK;
                     megakaryocyte-associated tyrosine kinase (non-receptor
                     protein tyrosine kinase); non-receptor protein kinase
                     protein"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein kinase
                     isoform 1"
                     /protein_id="NP_001424809.1"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
                     /translation="MPTQRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKS
                     WYRAKHHSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGL
                     FLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTRDKG
                     AICTKLVKPKRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKV
                     AVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLR
                     TRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK
                     AELRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE
                     VSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKLGRELRSVGVAAP
                     AGGQEAEGSAPTRSQDP"
     misc_feature    324..383
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    348..524
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    348..524
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(369..371,375..377,384..386,396..398,453..458,
                     501..503,507..512)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(369..371,375..377,384..386,396..398,453..458,
                     501..503,507..512)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    552..845
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    552..845
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    order(585..587,639..641,702..704,708..710)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(585..587,639..641,702..704,708..710)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(705..707,786..788)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    order(705..707,786..788)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    882..1646
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    882..1646
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(921..932,939..941,945..947,978..980,984..986,
                     1065..1067,1110..1121,1254..1256,1266..1271,1275..1277,
                     1305..1310)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(921..932,939..941,945..947,978..980,984..986,
                     1065..1067,1110..1121,1254..1256,1266..1271,1275..1277,
                     1305..1310)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    1656..1724
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            333..446
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            447..562
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            563..782
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            783..876
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            877..942
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1042
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1127
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1201
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1400
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1487
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1862
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactagacag cagcatccat cattttgtga gcacggagtt gggtccagat ggagtcccgt
       61 ctgggccgcg cagctcgctg aagccgcgaa gagccgcagc atctgaccct cccgccccaa
      121 gtcccgtccc cacggggaag gggaccccgt gcagaccaac tgaggccagt gcacagggct
      181 ggacccaaaa taggccggaa gccggcctag ccgccagggt gctaaaggct ggacccaggc
      241 tgcggatgca gggagcgttg ctaggagaca aggtgaaccc tcaattctaa ggagcttggc
      301 accccacgcc tgctgcagct aagatgccaa cgcaacgctg ggcccctggg actcaatgta
      361 tgaccaagtg cgagaactca cgccccaagc ccggtgagct agcctttcga aagggtgaca
      421 tggtgaccat cttggaggcc tgtgaggaca agagctggta ccgagccaag caccacagca
      481 gtgggcagga agggctgctg gcggctgctg ctctgcgaca gagggaggcc ctttccacag
      541 accccaagct cagcctcatg ccatggttcc atggcaagat ttccggtcag gaagccatac
      601 agcagctgca gccacccgag gatgggctgt tcctcgtgag ggaatcggcc cgtcaccctg
      661 gtgactatgt cctgtgtgtc agtttcggcc gtgatgtcat ccactaccgt gtcttgcatc
      721 gagatgggca cctcaccatt gatgaggccg tgtgtttctg taatctgatg gacatggtag
      781 agcactacac cagggacaag ggcgccatct gcaccaagct ggtgaagccc aagaggaaac
      841 agggcgcaaa gtccgcagag gaagagctcg ccaaggctgg ctggctgcta gacctgcagc
      901 atctgactct gggagcacag attggagagg gagagtttgg agccgtcctg cagggcgagt
      961 acttgggaca gaaggtggcc gtgaagaata taaagtgtga tgtgacagcc caggccttcc
     1021 tggatgagac ggctgtgatg acaaagctgc agcacaggaa cctagtgcga ctcctgggtg
     1081 tgatcctgca ccacggcctg tacattgtca tggaacacgt gagcaagggc aacctggtga
     1141 acttcctgcg cacgcggggc cgtgcgcttg tgagcacctc tcagctcctg cagtttgctc
     1201 ttcacgttgc tgaaggcatg gagtacctgg agagcaagaa gctggtacac agggacctgg
     1261 ctgctcgaaa catcctggtc tctgaggact tagtggccaa ggtcagtgac tttggcctag
     1321 caaaggcaga gcttaggaag gggctggact caagtcggct gccagtcaag tggacagcac
     1381 ccgaggctct caaaaatggg aggttctcca gcaagtcgga tgtctggagt tttggggtgc
     1441 tactgtggga agtcttctca tatggaagag ccccataccc caagatgtcg ctaaaggagg
     1501 tttcagaggc tgtggagaag ggttaccgca tggagccccc cgacagctgc ccaggccctg
     1561 tgcataccct catgggcagc tgctgggagg ctgagccctc gcgcagacca ccgttccgca
     1621 aaatagtgga gaagctgggt cgtgagctcc gcagtgtggg cgtcgcagcc cccgccgggg
     1681 gacaggaggc tgagggctca gctcccacac ggagccagga cccctgaccc ctgaactgga
     1741 aagcaagagg acacagatgt agggtcacag ggccagggtg agccagtgca caggctccgg
     1801 agcccctggg atccccgtta ctgggacacc ccataaagag tgattggaag gattttgtac
     1861 aa
//
LOCUS       NM_001437833            4193 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 2, mRNA.
ACCESSION   NM_001437833 XM_008761452
VERSION     NM_001437833.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008761452.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.876913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217877711-217877783
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1502           JAXUCZ010000002.1  217914468-217914509
            1503-1551           JAXUCZ010000002.1  217916935-217916983
            1552-1627           JAXUCZ010000002.1  217946550-217946625
            1628-1722           JAXUCZ010000002.1  217955065-217955159
            1723-1951           JAXUCZ010000002.1  217957098-217957326
            1952-2040           JAXUCZ010000002.1  217958485-217958573
            2041-4193           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4193
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..2018
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 2"
                     /protein_id="NP_001424762.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPIKPPCIPNGKENFSGGTSLWQNI"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1371..1373
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1425..1541
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1509..1511
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1515..1517
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1527..1529
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1986..1988
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1998..2000
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1502
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1551
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1627
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1722
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1951
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2040
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..4193
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgcattcag cagatcctgg
      781 aggctgtgct acactgccat cagatgggcg tagtccatcg ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagccccaaa ctactgtaat ccacaaccct gatggaaaca
     1501 aggagtcaac tgagagctca aataccacca ttgaggatga agacgtgaaa gcacgaaagc
     1561 aagagatcat caaagtcact gagcagctga ttgaagctat caacaatggg gacttcgagg
     1621 cttacacgaa aatctgtgat ccaggcctca ctgcctttga acccgaagca ttgggcaact
     1681 tagtggaagg gatggacttt cacagattct actttgaaaa tgctttgccc aaaatcaata
     1741 aaccaatcca cactatcatc ctgaaccctc acgtacacct ggtaggggat gatgcagcct
     1801 gcatagcata cattcggctc acacagtaca tggatggaaa tggaatgcca aagacaatgc
     1861 agtcagaaga gactcgagtg tggcaccgcc gtgatgggaa gtggcagaat attcactttc
     1921 atcgttcggg gtccccaaca gtccccatca agccaccctg tattccaaat gggaaagaaa
     1981 acttctcagg aggcacctct ttgtggcaaa acatctgaaa accattcaca tttgggtctt
     2041 ctaattgtca acagtgccac gtcttcattc tgtcctcaag gcacctggcg gggtgatcct
     2101 gggacatcct ctcctcttca tgcatgtttc tgagtgcatg aagttgtgaa ggttctacgt
     2161 gtaatgcata tgtgacacgt catcttacca tgtgacacgc catcttacca tgtattcctt
     2221 cctgtacatt gtttacactc cagctactgg acggatgttc catgcaaacg tcagttactg
     2281 ctggcaaact aaagagggag ctccgacaag aaaactccgc aatactccaa gttcagctga
     2341 tccatcaggt ttctctgtgg atgccaagat tcaaaagact tcataaaatt actgttcaat
     2401 gaatgacagt gtgtaagagg aaaggaaatc tttcaagaat gctgccatta atctatttgg
     2461 gcttctcatt gggattttgg ggttgatttt tttttcattt tttaaggcaa atatatatat
     2521 atatatatat atatatatat atatatatat atatatatat atgccttcag ttcctggtag
     2581 aaatgaatgg atgccttttc tctgaaagtg ttggtgttgg ataaatggat ggctatgtga
     2641 gccaagtcct gggtgattgt aggagcaaga atcgtttgct gttctaccat caaagccatg
     2701 ttgatttggg tcgagctctg tatactggaa aaattcacat cattttctag tttgattgct
     2761 ttcagatagg cacagttctg gtgaatgctt ggcactgatc ttggtttttc tttcctaaat
     2821 ctgtgttctg ttttcattat atactatttg ctcctttcct ttgtatttgt tttcttttcc
     2881 cactcttttc tttatctttc tctctcccac tttctttctt ttttatgttt tcctttctat
     2941 agctgatagt gtgtaaaaac agtaacattt gcatatgaag ttaaaataaa aatcaaggtc
     3001 ttctagaagc taaaactagc acttccggtc tctcacgggg ctgtggagtt gttagaagat
     3061 ttaaataaat acttaaataa gagaggaatg aattcagctt aggttaccac ttgtgcatag
     3121 gtatccttgc tctgttgaaa gtgttggaat tgttgagact taagctaaca gcagtaagag
     3181 cctgcttaca cagtcctggt tctccccaac tagatattga agaccaagtg gagcctgacc
     3241 agggttgcat gcagagcact tgttttggac cttccagact aggaggcatt tactgcctca
     3301 ctttcactag ctagccacag gaagagtgtt ctccatcctc ctagaggttg aacttgacct
     3361 tcgtgactag tgcagttcta gcttctctct tgagtcacag tagcatcctg atgccaggag
     3421 ttaggctttt gtccagatta aaacaacgag gaaaaggaaa tgccccagtt ttctttccgt
     3481 ttcccatttc ttctttgtcg attcggtccc tgggagactg tttctccgcg ctgaactgct
     3541 ttatggtgca tggaatctcc atcagcgtac ttctacccta gccactcaca ctccttagaa
     3601 gctgattttt aaagcagaag caaggaagca aaagtaaaac actcccttcc cctctttttc
     3661 ctcatttcac cttttggtgt tgattgctaa tcactttaga tatattgttg ctagtgaatg
     3721 tatgatagat gggttgaagc ttttctgata attagcacat gatttaaaac aatatatatt
     3781 taaaacaaat atatacagta catgtattga gccgtgttaa cctgccaatg agatctgtga
     3841 aaaacgtaat ggcctcactt ttccctttga atttctttta cctttctgtg aagcagctct
     3901 gcgtggcata catgtattta aaaacacaaa tagtggtaga atgggttttt tttttacact
     3961 tttaacttag catgtggtgt tgaagtatta ccatagatcc agtttgtctt ctgcactaag
     4021 atgtgaggaa atcgtgattt gttctctcca gcacagtgga attacacctt catcatcttc
     4081 tattgttttg aaaacactgc agtttaccat gggacactgt atataattct tgccgtaatg
     4141 gtaaatgaca aattgatata tttaagagtt aataaatttg tgatttctgc tga
//
LOCUS       NM_001437858            3651 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 8, mRNA.
ACCESSION   NM_001437858 XM_008770495
VERSION     NM_001437858.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770495.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.44587.1,
                                           SRR26360176.601146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1104           JAXUCZ010000015.1  3601575-3601619
            1105-1153           JAXUCZ010000015.1  3604223-3604271
            1154-1267           JAXUCZ010000015.1  3605519-3605632
            1268-1343           JAXUCZ010000015.1  3607566-3607641
            1344-1438           JAXUCZ010000015.1  3607997-3608091
            1439-1683           JAXUCZ010000015.1  3609598-3609842
            1684-3651           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3651
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1671
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 8 is encoded by transcript variant 8;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 8"
                     /protein_id="NP_001424787.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKEPQT
                     TVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSLVPEGRSPRDRTAPSAGMQPQ
                     PSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFH
                     KFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETR
                     VWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1270..1653
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1270..1653
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1104
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1153
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1267
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1343
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1438
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1683
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..3651
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaagg agccacaaac caccgtggta
     1081 cataatgcta cagatgggat caagggctcc acagagagct gcaacaccac cacagaagac
     1141 gaagatctca aagctgcccc gctccgcact gggaatggca gcttggtgcc tgaaggacgg
     1201 agcccccggg acagaacagc cccctctgca ggcatgcagc cccagccttc tctctgctcc
     1261 tcagccatgc gaaaacagga gatcattaag atcacagaac agctgataga agccatcaac
     1321 aatggggact ttgaggccta cacgaagatt tgtgacccag gcctcacttc ctttgagcca
     1381 gaagcccttg gtaacctcgt ggaggggatg gatttccata agttttactt tgagaatctc
     1441 ctgtccaaga acagcaagcc tatccacacc accatcctaa acccacatgt ccatgtcatc
     1501 ggcgaggacg cagcttgcat cgcctacatc cggctcaccc agtacatcga tgggcagggt
     1561 cggcctcgca ccagtcagtc agaggagacc cgggtgtggc accgccggga tggcaagtgg
     1621 ctcaatgtcc actatcactg ctcaggagcc cctgctgcac cgctgcagtg agctcaggca
     1681 caggggcatt aggagattcc agctggaggc tgaaccttcg aagtcagtga ctctggaggg
     1741 cctgagtgac agccgcggtc ctgtccattt gaggtttaaa acaattacat tacaaagcgg
     1801 cagcagccaa tgcacgcccc tgcatgcagc cctcccgccc gcccttcgtg tctgtctctg
     1861 ctgtactgag gtgtttttta catttaagaa aaaaaaaaga aaataagatt gttttaaaaa
     1921 aaaatggaat tcataccatg atgcgtttta aaacaactga tagcctttgg gcttgaagaa
     1981 ggcaggagtt tgtatgatgc tcatccaggc gtgaacagag ggctcaccca ctggctttga
     2041 agaggtgagc ttggcctcag gcccccatgg actcgggggg gaccaggcaa ggactcttga
     2101 cagagctttg gtcatggaca gagccatgct gtggttgcag ccccggtggt gacctgatca
     2161 ctccaggtct aggagtggac ttcttcagaa tatacattga cacctagtat gagaaagaag
     2221 aaaactccat ggctaacaga cctacttggg agagaacgca gcgctcccag cccgctgtgg
     2281 aggcaactgt gaagcgtggc ctcgggactg aaggcctgga ctttgccgta ccgttccagt
     2341 tagtgtagac aggaagagaa ttggtgctgc agaagtgtgt ccgacacaga gccggtgtga
     2401 aacctcgcgt tagtctgaca cgcacttact catccatttc tataggatgc acaatgcacg
     2461 tgggcctgag actgaggcct gatttctgca ggcgagaagg gggtgggatt gctactttgt
     2521 ttcctgttgg ttttcctaat gtatcaagga gagatccaga catcgttggc cagggctcct
     2581 gttgccactt tctgcagttg tgtttgtgtg cggatctgga ccactttgtc ttatattttc
     2641 gtggcggtgg tccccatgcc gaccctctgc caagtgcccc tgcgggatgg gaggagtgag
     2701 ataagagttg gtggttgttt ctatgcattc tggctgccct ctgggctgcc tcccttcttc
     2761 ccgtgctgca cgtccgtctc tttccctgag tttgagattg aaccgactgc ttgggtgaga
     2821 agtgtcctct ttaatgaggc tctctaccga ccaactgaag tatagacttt tctgctggac
     2881 aatctgcatg ggcatcaccc cctcacctgc atgtacccaa aaaggggtcc agagccaagg
     2941 ctcctgtagt cattgtccct ctctgtgctc aaggagttcc tttccaggag gaaaagatct
     3001 gtaccttagg cagataacag agaagacaat ggaggagcaa ttggtcatag tcttggttcc
     3061 ctcccaccca acagctgcac actatctgca ttttgggggg gaaggtgggt tgacttcagc
     3121 tctttggatg accttcaggg aggcacagga gctgggaaaa gatacagaac tacagacttt
     3181 ggaaccagct gagaagagaa caaactcatg ggtgctggtg cttgaattta gccaggctcc
     3241 tcaagcacct tgtgcatgcc tcagaccctg gaccctagcc ccttcctgcc ctgcagcctg
     3301 cagtgccagc caacagatcc cttcaccaca gggtttggtt ttgctggctt gaagacaaca
     3361 aatggtctta gagctcattg agacccatag cttcatatgg ctgctccagc cccacttagc
     3421 gttcttactc cacttctggg gctaatgtca gcatctatag acaattaata gactatttaa
     3481 aaaaaaaaac caccttttaa acaggaaatg aaaggcattt gatgcagaac ttttgcatga
     3541 cgacatagaa ataatttaaa aatagtgttt gttctgaatg ttggtagtcc cttcatagct
     3601 ttgttacaat gaaaccttga agatatttaa taaaataacc tttaaacagt c
//
LOCUS       NM_001437873            2452 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus doublesex and mab-3 related transcription factor
            3 (Dmrt3), transcript variant 2, mRNA.
ACCESSION   NM_001437873 XM_063287107
VERSION     NM_001437873.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Andersson,L.S., Larhammar,M., Memic,F., Wootz,H., Schwochow,D.,
            Rubin,C.J., Patra,K., Arnason,T., Wellbring,L., Hjalm,G.,
            Imsland,F., Petersen,J.L., McCue,M.E., Mickelson,J.R., Cothran,G.,
            Ahituv,N., Roepstorff,L., Mikko,S., Vallstedt,A., Lindgren,G.,
            Andersson,L. and Kullander,K.
  TITLE     Mutations in DMRT3 affect locomotion in horses and spinal circuit
            function in mice
  JOURNAL   Nature 488 (7413), 642-646 (2012)
   PUBMED   22932389
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Konno,D., Iwashita,M., Satoh,Y., Momiyama,A., Abe,T., Kiyonari,H.
            and Matsuzaki,F.
  TITLE     The mammalian DM domain transcription factor Dmrta2 is required for
            early embryonic development of the cerebral cortex
  JOURNAL   PLoS One 7 (10), e46577 (2012)
   PUBMED   23056351
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Ahituv,N., Zhu,Y., Visel,A., Holt,A., Afzal,V., Pennacchio,L.A. and
            Rubin,E.M.
  TITLE     Deletion of ultraconserved elements yields viable mice
  JOURNAL   PLoS Biol 5 (9), e234 (2007)
   PUBMED   17803355
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063287107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.944210.1,
                                           SRR22582419.957498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000001.1  232674784-232674879
            97-777              JAXUCZ010000001.1  232675099-232675779
            778-2452            JAXUCZ010000001.1  232687161-232688835
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..2452
                     /gene="Dmrt3"
                     /note="doublesex and mab-3 related transcription factor 3"
                     /db_xref="GeneID:293976"
                     /db_xref="RGD:1306043"
     exon            1..96
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..777
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1739
                     /gene="Dmrt3"
                     /codon_start=1
                     /product="doublesex and mab-3 related transcription factor
                     3"
                     /protein_id="NP_001424802.1"
                     /db_xref="GeneID:293976"
                     /db_xref="RGD:1306043"
                     /translation="MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGH
                     KRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGD
                     AAATAATASQSSPASQASQPPAPPRPATELAAAAALRWVAEPQPGTLPAQIAKPDLTE
                     DRLGDSSSADNAAESFSDKDTDQRSSPDVVKSKNCFTPESPEIVSVDEGGYAVQKNGG
                     NPESCPDSPKYHAEQSHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELI
                     LKGCGGDLVSAVEVLLSSRSSAAGAERTAEESLVLPSSGHIFEHTLGSYPISSSKWSV
                     GSAFRVPDTLRFSADSSNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQSSPFLPND
                     VTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLSSRTTEDPRISIPDDGCPIVA
                     KQSIYTEDDYDERSDSSDSRILNTSS"
     misc_feature    381..521
                     /gene="Dmrt3"
                     /note="DM DNA binding domain; Region: DM; pfam00751"
                     /db_xref="CDD:459924"
     misc_feature    381..521
                     /gene="Dmrt3"
                     /note="DM DNA binding domain; Region: DM; pfam00751"
                     /db_xref="CDD:459924"
     misc_feature    573..698
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    747..893
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1065..1193
                     /gene="Dmrt3"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor 3 (DMRTA3); Region:
                     CUE_DMA_DMRTA3; cd14419"
                     /db_xref="CDD:270602"
     misc_feature    1065..1193
                     /gene="Dmrt3"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor 3 (DMRTA3); Region:
                     CUE_DMA_DMRTA3; cd14419"
                     /db_xref="CDD:270602"
     misc_feature    1560..1736
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            778..2452
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtccctcc cggctcagaa aggggtaaca gagggcttgg aagagggggc tttgagcgcc
       61 cccgcctgag aggcctggct gcaggtggcg gggaagctgc cctgagagcc tcggcgtggg
      121 aggaccagcg ggtggagttt gctccgggga gagcggcgag cagagaggcg gcgcgcgtgg
      181 ggacccgcgg gctgagagca ccatcggagc ggaggagact gcagccgtac ctccggctgc
      241 tgccgacctt cccgggcctc cgagctccgc gctccagctc ccgccgtcga ccagggggag
      301 ccctgggcat gaacggctac ggctccccct acctgtacat gggcggcccg gtgtcgcagc
      361 cgccgcgggc gcccttgcag cggacgccca agtgcgcgcg ctgccggaac cacggggtgc
      421 tatcctggct taagggccac aagcgctact gtcgcttcaa ggactgcacc tgcgagaagt
      481 gcatcctgat catcgagcgg cagcgggtga tggcggcgca ggtggcgctg cggcggcagc
      541 aggccaacga gagcctggag agcctcatcc cggactcgct gcgggctctg ccagggcctc
      601 cgccgccggg ggacgccgcg gccaccgccg ccaccgcctc gcagtcgtcc ccagcctccc
      661 aggcgtccca gccgccggcg ccgcctcgtc ccgccaccga gttggccgcg gccgctgcgc
      721 tgcgctgggt cgccgagccc cagcccggga cgctgccagc gcagattgct aagccagatt
      781 tgactgaaga ccgacttggg gacagcagtt cagcagacaa tgctgcggag tccttcagtg
      841 acaaagacac cgaccagagg agctccccag atgtggtcaa aagcaagaac tgcttcactc
      901 cggagagccc cgagatcgtg tccgtggatg aaggtgggta cgccgtgcag aaaaacgggg
      961 gcaacccgga gagctgccct gacagcccca agtaccacgc tgagcagagc catctcctga
     1021 tcgagggccc gtcagggacc gtctctctgc ccttcagctt gaaagccaac cggccacccc
     1081 tggaagtgtt gaagaaaatc tttcccaacc agaagcccac tgtactggag ctcatcctga
     1141 aaggctgcgg gggcgacctg gtcagtgccg tggaggtcct gctgtccagt cggtcctccg
     1201 cggctggggc ggagcggacg gccgaagaga gcctggtgct gccctccagc ggccatatct
     1261 ttgaacacac gctgggctcc taccctatct cttcctccaa gtggtccgtg ggctctgcct
     1321 tccgagtccc tgacacctta cgcttttccg cggactccag caacgtggtc cccaacccct
     1381 tggccgtgcc cctgcaacat cctttccccc agccaccccg gtatccgctg atgctgagga
     1441 atactttggc cagaaaccag tcgagcccct ttttgcccaa tgacgtcacc ctgtggaata
     1501 ccatgacact gcagcagcag taccagctga ggtcccagta tgtcagtcca tttcccagta
     1561 actccactag cgtcttccgg agctcgcccg tgctctcctc tcgcaccaca gaagaccctc
     1621 ggatctctat ccccgacgat gggtgtccaa tcgtggcaaa gcagtccatt tacacagagg
     1681 atgactatga tgagaggtcc gactcctcgg attctagaat actcaacacg tcatcctaaa
     1741 gtgtacctgt gggtggtgac tgggtgacat tttgtgtgtg ctggacctct cccccccgcc
     1801 cccgccccag ggagagtcca ctaatactgt atactctttc ttcctgtttg acaaagtgac
     1861 tgtgcttggt agtcttatac attagcaata aaaacataac ttatttaatt tcctgcactt
     1921 cactggaaaa tgccaaatag ctctgctctg tggatttagt gctgaatgtt gtaaatgagt
     1981 ttaaagctga ggactgcctg gggaggccgg gccagtgggg gatttaattg ggggtggggg
     2041 tcagctttac tcctaagttc aacctggaat gttccgtgaa atagtatact tgaatgccat
     2101 tttgtaaaag aggattcctc aggataccgg aaaccttagg gagtggctct attgccagcc
     2161 gacaaagagt agggacactc atgttactcc cgttctaaag agagactgca ctcaggctag
     2221 ctcggacggc acaggctcat atttaagctc ggacagtttt cagagacaaa ctccattaag
     2281 aatcattctt ttcacgtggc cgaatcgaaa catgtgtaat gtcagtataa agccaacccc
     2341 agctgtgaac tgcatgaaac gtgtcgccgc ggaaacgaac acaagattaa gctttgtcag
     2401 gttaatgtag catgctaagt aaggactcta gaaaaataaa ctaaggacat ga
//
LOCUS       NM_001437870            6419 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus myosin heavy chain 14 (Myh14), transcript variant
            4, mRNA.
ACCESSION   NM_001437870 XM_063261923
VERSION     NM_001437870.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6419)
  AUTHORS   Billington,N., Wang,A., Mao,J., Adelstein,R.S. and Sellers,J.R.
  TITLE     Characterization of three full-length human nonmuscle myosin II
            paralogs
  JOURNAL   J Biol Chem 288 (46), 33398-33410 (2013)
   PUBMED   24072716
REFERENCE   2  (bases 1 to 6419)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   3  (bases 1 to 6419)
  AUTHORS   Choi,B.O., Kang,S.H., Hyun,Y.S., Kanwal,S., Park,S.W., Koo,H.,
            Kim,S.B., Choi,Y.C., Yoo,J.H., Kim,J.W., Park,K.D., Choi,K.G.,
            Kim,S.J., Zuchner,S. and Chung,K.W.
  TITLE     A complex phenotype of peripheral neuropathy, myopathy, hoarseness,
            and hearing loss is linked to an autosomal dominant mutation in
            MYH14
  JOURNAL   Hum Mutat 32 (6), 669-677 (2011)
   PUBMED   21480433
REFERENCE   4  (bases 1 to 6419)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 6419)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 6419)
  AUTHORS   Kim,K.Y., Kovacs,M., Kawamoto,S., Sellers,J.R. and Adelstein,R.S.
  TITLE     Disease-associated mutations and alternative splicing alter the
            enzymatic and motile activity of nonmuscle myosins II-B and II-C
  JOURNAL   J Biol Chem 280 (24), 22769-22775 (2005)
   PUBMED   15845534
REFERENCE   7  (bases 1 to 6419)
  AUTHORS   Turney,S.G. and Bridgman,P.C.
  TITLE     Laminin stimulates and guides axonal outgrowth via growth cone
            myosin II activity
  JOURNAL   Nat Neurosci 8 (6), 717-719 (2005)
   PUBMED   15880105
REFERENCE   8  (bases 1 to 6419)
  AUTHORS   Bao,J., Jana,S.S. and Adelstein,R.S.
  TITLE     Vertebrate nonmuscle myosin II isoforms rescue small interfering
            RNA-induced defects in COS-7 cell cytokinesis
  JOURNAL   J Biol Chem 280 (20), 19594-19599 (2005)
   PUBMED   15774463
  REMARK    Erratum:[J Biol Chem. 2006 Apr 14;281(15):10652]
REFERENCE   9  (bases 1 to 6419)
  AUTHORS   Donaudy,F., Snoeckx,R., Pfister,M., Zenner,H.P., Blin,N., Di
            Stazio,M., Ferrara,A., Lanzara,C., Ficarella,R., Declau,F.,
            Pusch,C.M., Nurnberg,P., Melchionda,S., Zelante,L., Ballana,E.,
            Estivill,X., Van Camp,G., Gasparini,P. and Savoia,A.
  TITLE     Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and
            mutated in patients affected by autosomal dominant hearing
            impairment (DFNA4)
  JOURNAL   Am J Hum Genet 74 (4), 770-776 (2004)
   PUBMED   15015131
REFERENCE   10 (bases 1 to 6419)
  AUTHORS   Golomb,E., Ma,X., Jana,S.S., Preston,Y.A., Kawamoto,S.,
            Shoham,N.G., Goldin,E., Conti,M.A., Sellers,J.R. and Adelstein,R.S.
  TITLE     Identification and characterization of nonmuscle myosin II-C, a new
            member of the myosin II family
  JOURNAL   J Biol Chem 279 (4), 2800-2808 (2004)
   PUBMED   14594953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063261923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1373.1,
                                           SRR26643289.1557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000001.1  104295307-104295344 c
            39-434              JAXUCZ010000001.1  104289705-104290100 c
            435-591             JAXUCZ010000001.1  104284583-104284739 c
            592-619             JAXUCZ010000001.1  104282021-104282048 c
            620-722             JAXUCZ010000001.1  104281725-104281827 c
            723-815             JAXUCZ010000001.1  104279177-104279269 c
            816-879             JAXUCZ010000001.1  104278794-104278857 c
            880-978             JAXUCZ010000001.1  104277494-104277592 c
            979-1119            JAXUCZ010000001.1  104276344-104276484 c
            1120-1215           JAXUCZ010000001.1  104269048-104269143 c
            1216-1334           JAXUCZ010000001.1  104266200-104266318 c
            1335-1487           JAXUCZ010000001.1  104264350-104264502 c
            1488-1661           JAXUCZ010000001.1  104264084-104264257 c
            1662-1835           JAXUCZ010000001.1  104263419-104263592 c
            1836-1950           JAXUCZ010000001.1  104262885-104262999 c
            1951-2138           JAXUCZ010000001.1  104258734-104258921 c
            2139-2260           JAXUCZ010000001.1  104257865-104257986 c
            2261-2330           JAXUCZ010000001.1  104257345-104257414 c
            2331-2491           JAXUCZ010000001.1  104256789-104256949 c
            2492-2600           JAXUCZ010000001.1  104256018-104256126 c
            2601-2732           JAXUCZ010000001.1  104255157-104255288 c
            2733-2939           JAXUCZ010000001.1  104254399-104254605 c
            2940-3077           JAXUCZ010000001.1  104253811-104253948 c
            3078-3201           JAXUCZ010000001.1  104253374-104253497 c
            3202-3373           JAXUCZ010000001.1  104253051-104253222 c
            3374-3586           JAXUCZ010000001.1  104251920-104252132 c
            3587-3731           JAXUCZ010000001.1  104250259-104250403 c
            3732-3938           JAXUCZ010000001.1  104249888-104250094 c
            3939-4043           JAXUCZ010000001.1  104249228-104249332 c
            4044-4196           JAXUCZ010000001.1  104248994-104249146 c
            4197-4445           JAXUCZ010000001.1  104247889-104248137 c
            4446-4658           JAXUCZ010000001.1  104246686-104246898 c
            4659-4871           JAXUCZ010000001.1  104242891-104243103 c
            4872-5033           JAXUCZ010000001.1  104242094-104242255 c
            5034-5162           JAXUCZ010000001.1  104241139-104241267 c
            5163-5251           JAXUCZ010000001.1  104240531-104240619 c
            5252-5375           JAXUCZ010000001.1  104240317-104240440 c
            5376-5584           JAXUCZ010000001.1  104238455-104238663 c
            5585-5693           JAXUCZ010000001.1  104235388-104235496 c
            5694-5866           JAXUCZ010000001.1  104233615-104233787 c
            5867-6419           JAXUCZ010000001.1  104232778-104233330 c
FEATURES             Location/Qualifiers
     source          1..6419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6419
                     /gene="Myh14"
                     /note="myosin heavy chain 14"
                     /db_xref="GeneID:308572"
                     /db_xref="RGD:1306821"
     exon            1..38
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            39..434
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..6020
                     /gene="Myh14"
                     /EC_number="5.6.1.8"
                     /note="isoform 2 is encoded by transcript variant 4;
                     myosin, heavy polypeptide 14; myosin-14; myosin, heavy
                     chain 14, non-muscle"
                     /codon_start=1
                     /product="myosin-14 isoform 2"
                     /protein_id="NP_001424799.1"
                     /db_xref="GeneID:308572"
                     /db_xref="RGD:1306821"
                     /translation="MATVTLSVPGRKVASRPGPVPEAAQPFLFAPRTPNVGGPGGPQV
                     EWTARRMVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSK
                     AEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRG
                     KKRHEVPPHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSP
                     KGRKEPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGAN
                     IETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFLTNGPSSSP
                     GQERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTA
                     AQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRW
                     LVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFV
                     LEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVE
                     KVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQ
                     STDRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLS
                     NTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQR
                     YEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLK
                     VTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKP
                     LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE
                     LCSEAEETRARLAARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQHIQELETHL
                     EAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAE
                     EEEKVKSLNKLRVKYEATIADMEDRLKKEEKGRQELEKLKRRLDGESSELQEQMMEQK
                     QRAEELLIQLGRKEEELQSALVRAEEEGGARAQLLKSLREAQAGLAEAQEDLEAERVA
                     RAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEEARTHE
                     VAMQELRQRHSQALVELTEQLEQARRGKSVWEKTRLSLEAEVSELKTELSSLQTSRQE
                     GEQKRRRLESQLQEVQGRSSDSERARAEAAEKLQRAQVELESVSTALSEAESKAIRLS
                     KELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVVARERAGRE
                     LQTTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLAQRLAEKTEAVERLERARR
                     RLQQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGRER
                     EARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKNVHELERARRVAEQ
                     AASDLRTQVTELEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEERRRQLAKQ
                     LRDAEVERDEERKQRALAMAARKKLELELEELKAQTSAAGQGKEEAVKQLKKMQAQMK
                     ELWREVEETRSSREEMFTLSRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM
                     AEEVASGNLSKAATLEEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKLVLQVETLTT
                     ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKMLIAALESKLAQAEEQ
                     LEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKSNLRLKQLKRQLE
                     EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFR
                     LEEGVASDEEEAEGAEPGSAPTQEPEAPPPAAPQ"
     misc_feature    384..2393
                     /gene="Myh14"
                     /note="class II myosin heavy chain 14 motor domain;
                     Region: MYSc_Myh14_mammals; cd14930"
                     /db_xref="CDD:276893"
     misc_feature    384..2393
                     /gene="Myh14"
                     /note="class II myosin heavy chain 14 motor domain;
                     Region: MYSc_Myh14_mammals; cd14930"
                     /db_xref="CDD:276893"
     misc_feature    order(465..491,621..644,780..812,1461..1478)
                     /gene="Myh14"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(465..491,621..644,780..812,1461..1478)
                     /gene="Myh14"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276893"
     misc_feature    465..491
                     /gene="Myh14"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    465..491
                     /gene="Myh14"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    621..644
                     /gene="Myh14"
                     /note="P-loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    621..644
                     /gene="Myh14"
                     /note="P-loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    780..812
                     /gene="Myh14"
                     /note="switch I region; other site"
                     /db_xref="CDD:276893"
     misc_feature    780..812
                     /gene="Myh14"
                     /note="switch I region; other site"
                     /db_xref="CDD:276893"
     misc_feature    1461..1478
                     /gene="Myh14"
                     /note="switch II region; other site"
                     /db_xref="CDD:276893"
     misc_feature    1461..1478
                     /gene="Myh14"
                     /note="switch II region; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(1548..1583,1590..1619)
                     /gene="Myh14"
                     /note="relay loop [active]"
                     /db_xref="CDD:276893"
     misc_feature    order(1548..1583,1590..1619)
                     /gene="Myh14"
                     /note="relay loop [active]"
                     /db_xref="CDD:276893"
     misc_feature    2187..2216
                     /gene="Myh14"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276893"
     misc_feature    2187..2216
                     /gene="Myh14"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(2223..2273,2346..2393)
                     /gene="Myh14"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(2223..2273,2346..2393)
                     /gene="Myh14"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276893"
     misc_feature    2622..5864
                     /gene="Myh14"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:460256"
     misc_feature    2622..5864
                     /gene="Myh14"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:460256"
     exon            435..591
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            592..619
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            620..722
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            723..815
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            816..879
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            880..978
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1119
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1215
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1334
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1487
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1661
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1835
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1950
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2138
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2260
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2330
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2491
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2600
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2732
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2939
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3077
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3201
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3373
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3586
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3731
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3938
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4043
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4196
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4445
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4658
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4659..4871
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..5033
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5034..5162
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5251
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5252..5375
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5584
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5585..5693
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5694..5866
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..6419
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtccaggc cgaggcctct ggaccgccct gggcgccgac catggccaca gtgaccttgt
       61 ccgtgcctgg gaggaaggtg gcctccaggc caggcccggt gcctgaggca gcccagccat
      121 tcctgttcgc gccccggacg ccaaatgtag gtggccctgg agggccacag gtggagtgga
      181 cagcacggcg catggtgtgg gtgccctcgg aactgcatgg gttcgaggca gcagccctgc
      241 gggatgaagg ggaggaggag gcagaagtgg agctggcgga gagtgggcgg cgcctgcggc
      301 tgcccaggga ccagatccag cgcatgaacc cacccaagtt cagcaaggca gaagatatgg
      361 ctgagctcac ctgcctcaac gaggcctcgg tcctgcacaa tctgcgagag cgctactact
      421 ctgggctcat ttatacctac tctggcctct tctgtgtggt cattaacccg tacaagcagc
      481 tgcctatcta cacggaggcc attgttgaaa tgtaccgggg caagaagcgc cacgaggtgc
      541 cacctcacat ctatgccgtg accgagggcg cgtaccgcag catgcttcag gatcgtgagg
      601 atcagtccat tctctgcacg ggagagtctg gagctgggaa gacggagaac accaagaagg
      661 tcatccagta cctggcccat gtggcatcat ctccaaaggg caggaaggaa cctggtgtcc
      721 ctggggagct agagcggcag cttcttcaag ccaaccccat cctagaagcc ttcggcaatg
      781 ccaaaacggt gaagaacgac aactcttccc gatttggcaa attcatccgc atcaactttg
      841 atattgctgg ctacatcgtg ggagcaaaca tcgagaccta tctgctggag aagtcccggg
      901 ccatcagaca ggccaaggac gaatgcagct tccatatctt ctaccagctg ctagggggcg
      961 ctggggagca gctaaaagct gacctccttc tggagcccta ctcccattac cgcttcctga
     1021 ccaacgggcc ctcatcatcc cccggccagg agcgggagtt attccaggag accctggagt
     1081 ccctgcgagt gctgggcctc ctcccagaag agatcactgc catgctgcgc acagtctcag
     1141 ctgtcctcca gtttggcaac attgtcctga agaaagagcg gaacacggat caagccacca
     1201 tgcctgacaa cacagctgcc cagaagcttt gccgcctctt gggacttgga gtgactgact
     1261 tctccagagc ccttctcacg ccccgcatca aagtcggccg agattacgtc cagaaagcac
     1321 agaccaaaga gcaggctgac tttgcgctgg aggctctggc caaagctacc tatgagcgcc
     1381 tgttccgctg gctggttctg cggctcaacc gtgccctgga cagaagccca cgtcagggcg
     1441 cctccttcct gggcatcctg gacatcgcag gctttgagat cttccagctg aactccttcg
     1501 agcagctgtg catcaactac accaatgaga agctgcagca gctgttcaac cacaccatgt
     1561 tcgtgctgga gcaggaggag taccagcgag aaggcatccc ctggaccttc ctggactttg
     1621 ggttggacct gcagccttgt atcgacctca ttgagcggcc ggccaaccct ccaggtctcc
     1681 tggccctgct ggacgaggag tgctggttcc ccaaggccac tgacaagtct tttgtggaga
     1741 aggttgccca ggagcagggc agccacccca agttccagcg tcctaggaac ctacgagatc
     1801 aagcggactt cagcgtcctg cactacgcag gcaaggttga ctacaaagcc aatgagtggt
     1861 tgatgaagaa catggatcca ttgaatgaca atgtggccgc cttgcttcac cagagcacag
     1921 atcgtctcac agctgagatc tggaaggatg tggagggcat cgtggggctg gagcaagtga
     1981 gcagccttgg agatggcccc ccgggaggcc gcccccgccg tggaatgttc cggaccgtgg
     2041 ggcagctcta caaagaatcc ctgagccgcc tcatggccac gctcagcaac accaacccta
     2101 gttttgtccg ctgcatcgtt cccaatcatg agaagagggc tgggaaactg gagccgcgcc
     2161 tggtgctgga ccagctccgt tgtaatggtg tcctcgaggg tatccgcatc tgtcgccaag
     2221 gtttccccaa ccgcatcctc tttcaggagt tccggcagcg ctatgaaatc ctcaccccga
     2281 acgccattcc caagggcttc atggacggca aacaggcctg tgagaagatg atccaggccc
     2341 tggagctaga ccccaacttg taccgtgttg gccaaagcaa gatcttcttc cgggcagggg
     2401 tcctagctca actggaggag gagcgagatc tcaaggtcac cgacatcata gtatcttttc
     2461 aggcagcggc acggggctac ctggcccgta gggctttcca gaggaggcag cagcagcaga
     2521 gtgctctgag ggtgatgcag agaaactgtg ccgcctacct caagctgagg aactggcagt
     2581 ggtggagact gttcatcaag gtgaagcccc tgctgcaggt gacacggcag gatgaggtgc
     2641 tgcaggcgcg agcccaggag ctacagaaag ttcaggagct gcagcagcag agcgcccgtg
     2701 aagtggggga actgcagggt cgagtggcac agctagagga ggagcgtgcg cgcctggctg
     2761 agcagctgcg agcggaagcg gagctgtgct ctgaggcgga ggagacacgg gcacgattgg
     2821 ctgcccggaa gcaggagctg gagctggtgg tgacagagct ggaggcacga gtgggcgagg
     2881 aagaagagtg cagccggcag ctacagagcg agaagaagag gctgcagcag cacatccagg
     2941 agctggagac ccacctagaa gcagaggagg gtgcccggca gaaactgcag ctggagaaag
     3001 tgaccacaga ggccaagatg aagaagtttg aggaggatct gctgctcctg gaagaccaga
     3061 attccaagct gagcaaggag cggaggctgc tggaggagcg cctggctgag ttctcctcac
     3121 aggcagcaga agaggaagag aaagtcaaaa gccttaacaa gctgagggtc aaatatgaag
     3181 ccacaatcgc agacatggaa gaccgactga agaaagagga gaaaggccgc caggaactag
     3241 agaagctgaa gcgacggctg gatggggaga gctcagagct tcaggaacag atgatggagc
     3301 agaagcagag ggcagaggag ctgctcatac agctgggccg caaggaggaa gagctgcagt
     3361 cggccctggt cagggcagag gaggagggtg gtgcccgtgc tcagctgctc aagtctctgc
     3421 gagaggcaca ggctggcctt gctgaggccc aggaggacct ggaagctgag cgggtagcca
     3481 gggccaaggc ggagaagcag cgccgggacc tgggcgagga gttggaggcg ctccgcgggg
     3541 agctagagga cacgctggat tccaccaacg cccagcagga gctgcggtcc aagagggagc
     3601 aggaggtgac agagctgaaa aagactttgg aagaggaggc ccggactcac gaggtggcca
     3661 tgcaggagct gagacagagg catagccagg ccctggtgga gctgacagag cagttggagc
     3721 aagcacggag gggcaaaagt gtgtgggaga agacccggct ctccctggag gctgaggtgt
     3781 ctgaacttaa gacggagctg agcagcctgc agacctcaag acaggagggt gagcagaaga
     3841 ggcgacgcct ggagtcccag ctacaggagg tccagggccg atccagcgat tccgagaggg
     3901 ctcgggctga ggctgctgag aagctacaga gagcccaggt ggaacttgag agcgtgtcca
     3961 cagccctaag tgaggctgag tccaaggcca tcaggctgag caaggagctg agcagtgcag
     4021 agtcccagct gcacgacacc caggaactgc tgcaggagga gaccagggca aagctggctt
     4081 tggggtcccg tgtgcgtgcc ctggaggccg aggcagccgg gcttcgggag cagatggaag
     4141 aggaggtggt tgccagggaa cgggctggcc gagagctgca gaccacacag gcccagctct
     4201 ctgaatggcg gcgacgccag gaagaagagg ctgccgtgct ggaggctggg gaggaggctc
     4261 ggcgccgtgc agcccgggag gcagagaccc tggcccagcg cctggcagaa aagactgagg
     4321 ctgtagaaag actggagcga gcccggcggc ggctgcagca ggagctggac gacgccactg
     4381 tggacctggg gcagcagaaa cagctcctga gcacactgga gaagaagcag cgaaagtttg
     4441 accagctcct ggcagaggag aaggctgcag tgctacgggc tgtggaagat cgtgaacggg
     4501 tagaggctga aggccgggag cgagaggccc gggccctgtc gctgacacgg gccctggaag
     4561 aggagcagga ggcacgggag gagctggaga ggcagaaccg tgctctgcgg gctgagctgg
     4621 aggcactgct aagcagcaag gatgatgttg gcaagaatgt gcacgagctc gagcgagccc
     4681 gcagggtggc tgaacaggca gccagtgacc tgcggacaca ggtgacagaa ctggaggatg
     4741 agctgactgc cgcggaggat gccaaactgc gcctggaggt gactgtgcag gccctgaagg
     4801 ctcaacatga acgcgacctg cagggccgtg atgatgctgg cgaggagagg cggaggcagc
     4861 tggccaagca gctgagagac gcagaggtag agcgcgatga ggaacggaag cagagggcac
     4921 tggccatggc tgcccgcaag aagctggagt tggaactgga ggagttgaag gcacagacat
     4981 ctgctgctgg gcagggcaag gaagaggcag tgaagcagct gaagaagatg caggcccaga
     5041 tgaaggagct gtggcgggag gtggaggaga cgcgtagctc ccgcgaggag atgtttaccc
     5101 tgagcaggga aagtgagaag aggctcaagg ggttggaagc tgaggtgctg cggctgcagg
     5161 aggaactggc tgcctcagac cgagcccgga ggcaggcaca gcaggacaga gatgagatgg
     5221 cagaggaggt ggccagtggc aaccttagca aggcagccac cctggaggag aaacggcagc
     5281 tggaggggcg actgggccag ttggaagagg agctggagga agagcagaat aactcggagc
     5341 tgctcaagga ccactaccga aagctggtgc tacaggtaga gaccctcacc acagagctgt
     5401 ctgctgaacg cagtttctca gccaaggctg agagtggaag gcagcagctg gagcggcaga
     5461 tccaggaact gcgggcccgc ctgggtgaag aggatgctgg agccagagcc aggcagaaaa
     5521 tgctgatcgc cgctcttgag tctaaactgg cccaggcaga ggagcagctg gagcaggaga
     5581 gcagagagcg catcctctct ggcaagctgg tacgcagagc cgagaagcgg ctgaaggagg
     5641 tggttcttca ggtggatgaa gagcgcaggg tggctgacca gctccgggac cagctggaga
     5701 aaagcaacct ccggctgaag cagctcaaga gacagctgga ggaggcagag gaggaagcat
     5761 ctcgggcaca ggctggccgg aggcgtctgc agcgggagct ggaggacgtc actgagtctg
     5821 cagaatccat gaaccgggag gtgaccacgc tgaggaacag gctccggcgt ggcccgctta
     5881 ctttcaccac gcgaactgtg cgccaggtgt tccggctgga agagggcgtg gcttccgacg
     5941 aggaagaggc tgagggggca gagcctggtt ctgcaccaac ccaggagcct gaggctccgc
     6001 cccctgccgc tccccagtga tccagtctgt ccgagatgcc ccaaggacag agccctttct
     6061 ggtgtccctc ctggtttgca ctttgaaatg acactgtcct ctggcacttt ctggcatcga
     6121 tgaaccctac tgggacccca ggacccctgc tcactgggga ctccaaatca aggccccaaa
     6181 ccaaggagct gggtgggagg gaggcaagga tggtcgctca tgttagagaa acaaaattga
     6241 acatggatgt caaggatgtc cagtctgctc ctgttttcag caggcctgtc ccctggagag
     6301 gacaggaggg tgcttccacc ccctgtcttg ctctctttgg ggggaggggt gctcatagga
     6361 tagcgctcat ggtccctcat gctccagaca ctaaagaaat aaactggctg gacccttca
//
LOCUS       NM_001437807            8384 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 6, mRNA.
ACCESSION   NM_001437807 XM_063288661
VERSION     NM_001437807.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8384)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8384)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8384)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8384)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288661.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1014447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000001.1  9595970-9596116     c
            148-315             JAXUCZ010000001.1  9497140-9497307     c
            316-396             JAXUCZ010000001.1  9468266-9468346     c
            397-943             JAXUCZ010000001.1  9454995-9455541     c
            944-1146            JAXUCZ010000001.1  9448660-9448862     c
            1147-1303           JAXUCZ010000001.1  9447057-9447213     c
            1304-1359           JAXUCZ010000001.1  9441551-9441606     c
            1360-1421           JAXUCZ010000001.1  9435618-9435679     c
            1422-1559           JAXUCZ010000001.1  9433972-9434109     c
            1560-1636           JAXUCZ010000001.1  9426874-9426950     c
            1637-8384           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8384
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..147
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    129..131
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     CDS             135..1652
                     /gene="Phactr2"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 6"
                     /protein_id="NP_001424736.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MDKAVDGLDKASIANSDGPPAGSQTPPFKRKGKLSTIGKIFKPW
                     KWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQAGSSHPKKTTGSKAS
                     SSPSASSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLSPNTVTSETSSL
                     KGELSDTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPALPLPPEDPCTI
                     ALDTPMVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSREQAKCFTTKDG
                     PGKAGPQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTDDDDEEDDDDDS
                     TGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIGTKLVRRL
                     SQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEY
                     VEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP"
     misc_feature    318..383
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    318..383
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    1176..1253
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1176..1253
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1293..1367
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1293..1367
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1404..1481
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1404..1481
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            148..315
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..396
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..943
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1146
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1303
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1359
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1421
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1559
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1636
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..8384
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagtgcg tgaagtgtgt tctgtgtgcc agcaagggct gataatcagc agaagggcag
       61 ggtgctctgt tagccagaag agcccgggct tccgggctgc cagctgcccg gactcgcctc
      121 gccacttctg agccatggat aaagccgttg atggactaga caaagcctcc atagcaaact
      181 cagatggccc cccagcaggt tcccagacac ctcccttcaa gagaaagggg aaactctcca
      241 ccattggtaa aatcttcaag ccttggaaat ggaggaaaaa gaagaccagt gacaagttta
      301 gagagacctc agcagtatta gagaggaaga tatccaccag acaaagtaga gaggagctga
      361 taagaagggg cctgcttaag gaattgcctg atcaagctgg ttcctctcac ccgaagaaaa
      421 caactggttc caaagcctca tcctcaccat ctgcttcgtc cacctcctct catcccagag
      481 gacccaagga gtcactcact ggcaaagcag gcgcggttgg gaccacaagg ggcaagaaaa
      541 agattagcaa gcagccagca gcggcggcat cccgactgtc ccccaacaca gtcacttctg
      601 aaacgtctag tcttaaagga gagctctcag acactggggt agagagcctc aagccagagg
      661 aaactgttgc tggagcagag gaggaggcca caggcaaacc caaggcggtc gtcgtcgctc
      721 tgccacctgt cacagtaccg ccatcttcac ctgcccttcc tctgccccct gaggatccat
      781 gcactattgc cttggacact cccatggtcc tagtcagtga tggacccacc ctgcccatct
      841 ctgccttaga aacaagtccg ctccctggga ctgaagaacc agcgaacaga accactccgt
      901 actcaagcac cggcttaggt gggagccgag agcaggcaaa atgttttaca accaaagatg
      961 ggccgggaaa ggctggacct caattgctga cccctggaca gatgggagac tcattagaat
     1021 ccttcagtgc cccagaggat gaggccccaa gagagtacca agccaatgac tctgactcgg
     1081 atggacccat cttatacaca gatgatgatg atgaagaaga tgatgatgat gacagcactg
     1141 gagaaagtgc attggcaagt aagatcagac gaagggatac actcgccatc aaacttggca
     1201 acagaccatc caagaaagag ctagaggaca aaaacatcct gcagcgaacg tctgaagaag
     1261 aaaggcagga gctgcgacaa cagatcggaa ccaagctggt caggagactc agccagaggc
     1321 caaccactga agaattagag cagagaaaca tcttaaaaca aaagaatgaa gaagaggagc
     1381 aggaagcaaa aatggaactc aaacggaggc tcagccggaa gctcagccta agacctactg
     1441 tggcagagct acaagcccga agaatcctgc ggtttaatga gtatgtggaa gtcacagatt
     1501 ccccggacta cgacagacgt gcggacaagc cctgggccag gttgacacct gcggacaagg
     1561 cagcaataag gaaagaacta aatgaattta aaagcacgga aatggaagtt cacgaagaga
     1621 gtcgacagtt tacaaggttt caccgtccat aatgaagcat gggacagctt ggaaataagg
     1681 accctgacat tgcactgaga tttgaatgtg tgtgtttccg tttcgttgtg gtgaaggagg
     1741 tgtacgactc ggctttggtt gaagacgctc ctcaccctga cagcccagac gagggcaaca
     1801 agctgagagg cggatgcggc aagcctggct gcccacggtg tgcactgata taaggggcac
     1861 tctgactctc tcagctatgt ttcagcggga attttaatca aagaagacaa gcagaagaca
     1921 atcgccagtt tggctaccag aaagccatac ggtatagcac gtgtgggttc acaaacaata
     1981 gacattggaa ttgctggtgg ccaccccaac agggtgggag ctgaaactga gaaagagaga
     2041 gaaccgtttc attatgttaa tgaagagaag aagagtgaag agaagtatat ttttgaagta
     2101 ggcgttcggt agctgaggac ttcctaaggg atttgggaac ctactcaacc aacgtagatt
     2161 ccttaaagac ttcattctag aacattcttg tttcaccaat aatggttctg tgtagtagcc
     2221 tctttttttt ttttttttaa tgttgtgcca gtgaacccag ttgccagaaa caaatatgag
     2281 tgttcattca atgcaaggag ctcctaccag ctctcaccaa gcatgcttgc tcttgctgtg
     2341 ttgcatgcct ttcagtagta cagccaagcc cacactttct tatattgctt ccctaacgta
     2401 tgagcgctct acaagggtaa caggaatgag gtcagatgca atgtgaccct gtaaaactgt
     2461 ggcaagcttc agaaataaat cttctgctct ttccctgtct tgattctctc caaagtcagg
     2521 aaaccatcct ttagctaaag aagatgaccc ggacagtcat ggtacccttt aaacactcaa
     2581 tccagagttg tcacttaagc aacatacaag tgtctgctgc ctgctccaag tcctgagagg
     2641 ggatttaaag aacataccag atagtttaaa atcctgcatt aatttttttt taatattagg
     2701 ttgctgctat tttttttaaa aaaaagtgaa acagtaaaaa ccaagcatat gaatttaaca
     2761 aaaatatcct gaggcttaaa ggaacacaga agacgacttc tggtttatgt aaaggaaacc
     2821 ttaccttctc tgatgaattt gtggatcata tccatatacc cggtatttac tccccatgcc
     2881 agagaagcag taagatcccc gggccagctt ccccaggagt ctgtaatcag tcttgtttac
     2941 attaaaaagc ttcccccctc aaattgttct cttcagtgtc cggccccagc acagaacccc
     3001 agaagggctt acttgtgata ctaccttgaa tttcgttgtc ccttaacaat tgttttaagc
     3061 cccttggatt aaaagaagaa gaaaaagaag gcagaatcta tatcatgctt tttttttcct
     3121 taagaaggca gaatctatac caggtctatc tcattctttg atctggagct atgccgattc
     3181 tgaagcctgt aattttctat ttcgagtgaa cagtcagcct cgaatcagtc aagtaagtgt
     3241 aggccctgcc attctgtggt atctggaggg accgcttgaa atttgatgat ttcatttaaa
     3301 agtgaacgtg gttagcggca gcggactgtt gtgaaagccc agaggaaccg cgccacgagg
     3361 taaccagcgt tcatgcaccc accgccgtgc ttagccgttt gcggtaataa gacaaggctg
     3421 ctgcctacac tagttcgtct ggctaacagc atgaggcaga ctttgctttt gaaatagtgt
     3481 ctgtgcgtgc actagtgttt gtctttgtct ttgggggctt gctcgttcta ttgttgtttt
     3541 gcagtgccgg gactgaacca ggcccttgcg catgctctgt gtactctaac ccctgagcca
     3601 acacccctaa ccttcgtttg acaagagtct caactcaacc gtgaatagta attttgttct
     3661 cattacttat agagtagttt tccctcgtga tatcctacta tcgtcttagt gtcgtgggaa
     3721 aaagtgacaa gacaggtgat gttccttcgt ctatgcttat aatctcgaaa cgttttaaaa
     3781 accttctaat gaaatgtcct caaaatgttg taaattcaag acaggagcaa cacggcttgc
     3841 cattcaaagt gtgtttcata gaaagtttct gtctggttgg tcaaaagaac cttttttccc
     3901 cactagtggt gcaggtgaca caggttttaa tcttccacag ttaatgttca aaatgccacg
     3961 catcgttgaa gctcccagtt cagcccccag tactgcacaa acgaaaatct gtctcctgat
     4021 aacatctgcc agattggtgt tacctacacc ttttcttcat actaactgat acatttcaag
     4081 aagcttttgt gagaaagttt agaaagctaa aaaattaact actaacggtc taatatttaa
     4141 gtaacctggg accactgatg acttcattat gatggcctag tacctgtttt aaaagccgtg
     4201 ggaagaatta aaatatcacg agccaagctg tacttctcag aataaggctc tactttgctg
     4261 ggtaatttgt aaaggcagaa acgtttaaag gctacatagc cttagcagca gctcactcac
     4321 aggtctccat ccaggcatcc ccacagaagg caaagctccc tctccctgta attaccgctc
     4381 tgcccactgc cagcatttct gcagtccaac caacaagcag ctactcttta agaaaataaa
     4441 tgtgtgcaga aaccagggcg tgcgtgcgtg cgtgcgtgtg tgtgtgtgtg tgcatgtgtg
     4501 tgttgccatt gtaacacaat tccagttttt cactaaagca taccattagg caatggagtg
     4561 agcgttcctg actccggagt tatactaagg aaaagaaaat tagcccacct cactggaggc
     4621 cccaacaaga aaagaaactg gaccagacag aaaagccaaa gtggccattc ggagggagac
     4681 cctgttggta ttacggtatt gagaagacac taagctccct tcacgcagca gcctcgtggt
     4741 catcaccaac caaccaacgt gacgaatgca gtcctaatcc gtgttcgcca ggggcacctt
     4801 ggctggtcat ttcctgtagg tatgaaatgt ctggtggttt tgtgtgagct ataatttacc
     4861 tttatgttta ttccttaagt tgttttaacc cgaagtctgc aatatccaga gaaccatctc
     4921 gggtatttga gcacctatta aaggaaaggc aagcatatcc atctctctgc cttcccagtg
     4981 aagaagctga ctttctggtt tctttcttct tgcccttatc aacccaatga acgcagttct
     5041 ctgtctccga tgtcgggaga aagttctgga acttaattgc aaatatattt aaggaaagag
     5101 aagaatctaa taagcctttc aaaaaccacc aagtatggaa atgagtcgtg agtcctgaga
     5161 aaaggtcagg caggctttgt atcctgtaat taacccagcg atccattggc gcttttttaa
     5221 aaatacagga gtttgtactc gagggagaac atgggttcat ctcacatgtc cagatacgtg
     5281 caaccccaca gcaacacatg ccggacaccc gtgaccgtta ggctgtaggc acactagaaa
     5341 gaggccggtc tgccatgtag cagcggtctg tctgcatttg aacagtaaaa aatagtttcc
     5401 tcttctccat gtcttgttct aaaacatcca tcctgtgttg cttgggcttg gccctagccg
     5461 cgtattttag agacatcaac attccttagt gtatgtgaaa cgggcttaat ctaacacagg
     5521 atgtatggat ttatgtcctt ttcctcctcg gcacggcgga tttgtttatg cattcctaaa
     5581 tccccacttc acttacttat cgttacaagt acggggagct ctactgggga ggtcattttt
     5641 ccttcagggc tgtacaggac acagattgtc ccttcacccc ttaaaatgat taatcctttg
     5701 ttagtattcg ctgtctattg actggctgat atgtttttat ttaacaaaag cagaacgaac
     5761 ctttaggaga tatgtgctag aggggccaac ggggacaaaa aataagcaat tgtcaaatta
     5821 atgagaacag cttcctgaaa gaaaccatat tctcaggcaa ctcaaagtcg agctccacag
     5881 agggactcta ggtctcccta cagaggcact cggggaccaa agggtgatgg agatggaggt
     5941 gaccattctc gtttttgctt cctgtttccc ttttctaatc gttaagtcta aaacctcttt
     6001 tgaagcttga accactgttg gcatttctag aaagcaactg taataggggc tagtgctttt
     6061 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttttttag tatgactgta
     6121 ttttgttttg tttgtttgtt gaggccagct tcaccccata atttttttta aaaaaatttc
     6181 attttttaca tttaaaaaaa atgcaagttt ttttttccca aagaaatgga gagtcctgtg
     6241 gctgctatcc cggcctaatg ccagttttta accatgttgg gttgtgctgc agggaaatgc
     6301 cagttagcct gttgcttctt taacacagct gcctgtgaac aaagaagcgc tgatagatgt
     6361 ctcccggtgg gggtgctgtt ggtatttgga tctgggtaaa tccttgctgt gctgaaatgt
     6421 accacatgtt gcaagatgtt cagtatcctg ggctcctggt gactcaacac cagacattgt
     6481 gagaaccgga aaaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa
     6541 agagaagaaa aaagcttccc gtttgcctgc atagaaggat aaacccctca cctgagtgcc
     6601 actgtctcct gcaacaaggg tacatggggg aacctgcctg tctctaaata ccatgtctac
     6661 tgccttgcac gtctctaccc acttctcttt caaagccttc tgcttagatg cagcttaaac
     6721 tggcctgttc cctagaaaag agcttcctag gtagtcttgt ccattacggt gggcagcgtg
     6781 acatggcctg atatttctgg agggtacacg aagcaagtct tgttcattac ttctgtgtta
     6841 cttcagaact agactcctgg ttgccagaac acagtgtctc tgagtaaaac actggtcttt
     6901 ggaactcagc attggattct acctggtcat actgaagacc gagttgcaaa aagagtctcc
     6961 cttcctcctg ttgacaacgg agttaatcca cacaaaaaga cacggggact ccctcgtgta
     7021 aacatccaca cggttccgct ttcctaataa gacgtgcaaa tatgacatgt tggcaggaac
     7081 gtaggtaaac tggattgcat tcatgctgtt cacaccacag acgggcaaaa cgaaatgagt
     7141 tttcccccag gtgtagctcg atcaagctgt gctaaccgta cagaaagacg ctctttacgc
     7201 cactgaaatt aaatagtcag tgggtcttga aaaatattta gatgaattgc agctagctgc
     7261 aaggatggaa ttaattcctc ccattcttca cattaaaatt ctgaagactc cccgcccctc
     7321 ccccttcttt taagcatagc aacttggagt cagtaaaggt ggccatagcg taaacctata
     7381 gatggtgctt taaaacaaaa tcgtatcttt cttaatagca gtatttttta aagcagagaa
     7441 tagactgaaa gaagtaaatg cggcagaacg ctgttccaca ctcaggtaaa ttttgtggtt
     7501 tattaaaatg ccaataatat ttgtgcactt gccagcgtca ggggcttttc ccttaatgga
     7561 tgctctcggt gtgatttttt tcctcttctt taactgtatc gttacattgt ttagagagca
     7621 tccaccacca ggatttgcca ccgtagtgat aactagcatt aggaaagaat taccgagaac
     7681 tgagggtcaa accactttca tcacctaaac gacaggcact agttctttag tatttcttca
     7741 gtggcttggg tgtgcccatg tattcaaagc attccgcacg aattttacca gttaaatacc
     7801 ggctgaaaag tcagaccagt ctctctccgc acctcctctc tctgtaacaa tgtttcgttt
     7861 ttgttttgtt tttttcccat aatgagctgt ctgtgttctt ttgttatttc aaactttggt
     7921 tcaagtggta gcaatggtac acactgtgat ggtggggaga ctagctgggt gagtctctag
     7981 tgtgtgatct aatctttaca tgggtgtgct atctgtgggt gttgataact ggaactgtac
     8041 ccggacaaca cgacagtttc tctctcttcc tgttcctgat tcactactat atcatagtac
     8101 gtgggtatga cccctgcgag tatccacacc gaagcctatg tattccacaa ttgtaacctg
     8161 aaagaccatg cattatcttt ttttaattca tactggtgtt tgtgttattt aaagtggaaa
     8221 attataccct atctagtagt ataatgtaat ataataggat actccgctgt gcacagttcc
     8281 aagtgcctta gaacattgtt tagctttcct aagtatacgt aaatgcatat atgtgtgtat
     8341 aaaattggga aatgttacct caataaagtc attgggaaat ccta
//
LOCUS       NM_001437803            8744 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 1, mRNA.
ACCESSION   NM_001437803 XM_017589101
VERSION     NM_001437803.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8744)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8744)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8744)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8744)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017589101.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.121.1,
                                           SRR26360181.3308209.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000001.1  9680162-9680509     c
            349-516             JAXUCZ010000001.1  9497140-9497307     c
            517-597             JAXUCZ010000001.1  9468266-9468346     c
            598-756             JAXUCZ010000001.1  9463224-9463382     c
            757-1303            JAXUCZ010000001.1  9454995-9455541     c
            1304-1506           JAXUCZ010000001.1  9448660-9448862     c
            1507-1663           JAXUCZ010000001.1  9447057-9447213     c
            1664-1719           JAXUCZ010000001.1  9441551-9441606     c
            1720-1781           JAXUCZ010000001.1  9435618-9435679     c
            1782-1919           JAXUCZ010000001.1  9433972-9434109     c
            1920-1996           JAXUCZ010000001.1  9426874-9426950     c
            1997-8744           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8744
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..348
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2012
                     /gene="Phactr2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 1"
                     /protein_id="NP_001424732.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MAEAGRSPEMSPDQPDGQEAVAAEVPDPEPEAPGPPVPALRWLP
                     GDPSPRGRSQSDLSSASSRGRPLRVHISGSVDGLDKASIANSDGPPAGSQTPPFKRKG
                     KLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQDGD
                     VTVNFENSNGHMIHIGEEATQEENVGKPEEGNVSVCEKGPPREEQAEEKTAGSSHPKK
                     TTGSKASSSPSASSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLSPNTV
                     TSETSSLKGELSDTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPALPLP
                     PEDPCTIALDTPMVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSREQAK
                     CFTTKDGPGKAGPQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTDDDDE
                     EDDDDDSTGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIG
                     TKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARR
                     ILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTR
                     FHRP"
     misc_feature    519..584
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    519..584
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    1536..1613
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1536..1613
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1653..1727
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1653..1727
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1764..1841
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1764..1841
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            349..516
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..597
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..756
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1303
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1506
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1663
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1719
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1781
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1919
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1996
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..8744
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgcggcc gcctccccgc cctgccaacc ggccgggggc tccgcgcggg gccgcggcgg
       61 acagcacagc tctttgcgcc ggctccaccc tgcctgagct tgctccctcc tggagcctaa
      121 agcggatggc ggaagctggc aggagccctg agatgtcccc ggaccagcca gacggccagg
      181 aggcggtggc ggcggaggtt ccggaccccg agcccgaggc tcccggacca cccgtgcctg
      241 ccctgcgctg gcttcccggg gacccgagtc cccgcggccg ctcccagagc gacctgtcgt
      301 cggcctcgag ccggggccgc ccgctcagag tccacatctc cggctcagtt gatggactag
      361 acaaagcctc catagcaaac tcagatggcc ccccagcagg ttcccagaca cctcccttca
      421 agagaaaggg gaaactctcc accattggta aaatcttcaa gccttggaaa tggaggaaaa
      481 agaagaccag tgacaagttt agagagacct cagcagtatt agagaggaag atatccacca
      541 gacaaagtag agaggagctg ataagaaggg gcctgcttaa ggaattgcct gatcaagatg
      601 gagatgtaac agttaacttt gaaaattcaa acgggcacat gatacacatc ggagaggaag
      661 ctacccaaga ggagaatgta gggaaacctg aagaagggaa tgtctctgtg tgtgagaaag
      721 gaccacctcg agaggaacag gcagaagaga agacagctgg ttcctctcac ccgaagaaaa
      781 caactggttc caaagcctca tcctcaccat ctgcttcgtc cacctcctct catcccagag
      841 gacccaagga gtcactcact ggcaaagcag gcgcggttgg gaccacaagg ggcaagaaaa
      901 agattagcaa gcagccagca gcggcggcat cccgactgtc ccccaacaca gtcacttctg
      961 aaacgtctag tcttaaagga gagctctcag acactggggt agagagcctc aagccagagg
     1021 aaactgttgc tggagcagag gaggaggcca caggcaaacc caaggcggtc gtcgtcgctc
     1081 tgccacctgt cacagtaccg ccatcttcac ctgcccttcc tctgccccct gaggatccat
     1141 gcactattgc cttggacact cccatggtcc tagtcagtga tggacccacc ctgcccatct
     1201 ctgccttaga aacaagtccg ctccctggga ctgaagaacc agcgaacaga accactccgt
     1261 actcaagcac cggcttaggt gggagccgag agcaggcaaa atgttttaca accaaagatg
     1321 ggccgggaaa ggctggacct caattgctga cccctggaca gatgggagac tcattagaat
     1381 ccttcagtgc cccagaggat gaggccccaa gagagtacca agccaatgac tctgactcgg
     1441 atggacccat cttatacaca gatgatgatg atgaagaaga tgatgatgat gacagcactg
     1501 gagaaagtgc attggcaagt aagatcagac gaagggatac actcgccatc aaacttggca
     1561 acagaccatc caagaaagag ctagaggaca aaaacatcct gcagcgaacg tctgaagaag
     1621 aaaggcagga gctgcgacaa cagatcggaa ccaagctggt caggagactc agccagaggc
     1681 caaccactga agaattagag cagagaaaca tcttaaaaca aaagaatgaa gaagaggagc
     1741 aggaagcaaa aatggaactc aaacggaggc tcagccggaa gctcagccta agacctactg
     1801 tggcagagct acaagcccga agaatcctgc ggtttaatga gtatgtggaa gtcacagatt
     1861 ccccggacta cgacagacgt gcggacaagc cctgggccag gttgacacct gcggacaagg
     1921 cagcaataag gaaagaacta aatgaattta aaagcacgga aatggaagtt cacgaagaga
     1981 gtcgacagtt tacaaggttt caccgtccat aatgaagcat gggacagctt ggaaataagg
     2041 accctgacat tgcactgaga tttgaatgtg tgtgtttccg tttcgttgtg gtgaaggagg
     2101 tgtacgactc ggctttggtt gaagacgctc ctcaccctga cagcccagac gagggcaaca
     2161 agctgagagg cggatgcggc aagcctggct gcccacggtg tgcactgata taaggggcac
     2221 tctgactctc tcagctatgt ttcagcggga attttaatca aagaagacaa gcagaagaca
     2281 atcgccagtt tggctaccag aaagccatac ggtatagcac gtgtgggttc acaaacaata
     2341 gacattggaa ttgctggtgg ccaccccaac agggtgggag ctgaaactga gaaagagaga
     2401 gaaccgtttc attatgttaa tgaagagaag aagagtgaag agaagtatat ttttgaagta
     2461 ggcgttcggt agctgaggac ttcctaaggg atttgggaac ctactcaacc aacgtagatt
     2521 ccttaaagac ttcattctag aacattcttg tttcaccaat aatggttctg tgtagtagcc
     2581 tctttttttt ttttttttaa tgttgtgcca gtgaacccag ttgccagaaa caaatatgag
     2641 tgttcattca atgcaaggag ctcctaccag ctctcaccaa gcatgcttgc tcttgctgtg
     2701 ttgcatgcct ttcagtagta cagccaagcc cacactttct tatattgctt ccctaacgta
     2761 tgagcgctct acaagggtaa caggaatgag gtcagatgca atgtgaccct gtaaaactgt
     2821 ggcaagcttc agaaataaat cttctgctct ttccctgtct tgattctctc caaagtcagg
     2881 aaaccatcct ttagctaaag aagatgaccc ggacagtcat ggtacccttt aaacactcaa
     2941 tccagagttg tcacttaagc aacatacaag tgtctgctgc ctgctccaag tcctgagagg
     3001 ggatttaaag aacataccag atagtttaaa atcctgcatt aatttttttt taatattagg
     3061 ttgctgctat tttttttaaa aaaaagtgaa acagtaaaaa ccaagcatat gaatttaaca
     3121 aaaatatcct gaggcttaaa ggaacacaga agacgacttc tggtttatgt aaaggaaacc
     3181 ttaccttctc tgatgaattt gtggatcata tccatatacc cggtatttac tccccatgcc
     3241 agagaagcag taagatcccc gggccagctt ccccaggagt ctgtaatcag tcttgtttac
     3301 attaaaaagc ttcccccctc aaattgttct cttcagtgtc cggccccagc acagaacccc
     3361 agaagggctt acttgtgata ctaccttgaa tttcgttgtc ccttaacaat tgttttaagc
     3421 cccttggatt aaaagaagaa gaaaaagaag gcagaatcta tatcatgctt tttttttcct
     3481 taagaaggca gaatctatac caggtctatc tcattctttg atctggagct atgccgattc
     3541 tgaagcctgt aattttctat ttcgagtgaa cagtcagcct cgaatcagtc aagtaagtgt
     3601 aggccctgcc attctgtggt atctggaggg accgcttgaa atttgatgat ttcatttaaa
     3661 agtgaacgtg gttagcggca gcggactgtt gtgaaagccc agaggaaccg cgccacgagg
     3721 taaccagcgt tcatgcaccc accgccgtgc ttagccgttt gcggtaataa gacaaggctg
     3781 ctgcctacac tagttcgtct ggctaacagc atgaggcaga ctttgctttt gaaatagtgt
     3841 ctgtgcgtgc actagtgttt gtctttgtct ttgggggctt gctcgttcta ttgttgtttt
     3901 gcagtgccgg gactgaacca ggcccttgcg catgctctgt gtactctaac ccctgagcca
     3961 acacccctaa ccttcgtttg acaagagtct caactcaacc gtgaatagta attttgttct
     4021 cattacttat agagtagttt tccctcgtga tatcctacta tcgtcttagt gtcgtgggaa
     4081 aaagtgacaa gacaggtgat gttccttcgt ctatgcttat aatctcgaaa cgttttaaaa
     4141 accttctaat gaaatgtcct caaaatgttg taaattcaag acaggagcaa cacggcttgc
     4201 cattcaaagt gtgtttcata gaaagtttct gtctggttgg tcaaaagaac cttttttccc
     4261 cactagtggt gcaggtgaca caggttttaa tcttccacag ttaatgttca aaatgccacg
     4321 catcgttgaa gctcccagtt cagcccccag tactgcacaa acgaaaatct gtctcctgat
     4381 aacatctgcc agattggtgt tacctacacc ttttcttcat actaactgat acatttcaag
     4441 aagcttttgt gagaaagttt agaaagctaa aaaattaact actaacggtc taatatttaa
     4501 gtaacctggg accactgatg acttcattat gatggcctag tacctgtttt aaaagccgtg
     4561 ggaagaatta aaatatcacg agccaagctg tacttctcag aataaggctc tactttgctg
     4621 ggtaatttgt aaaggcagaa acgtttaaag gctacatagc cttagcagca gctcactcac
     4681 aggtctccat ccaggcatcc ccacagaagg caaagctccc tctccctgta attaccgctc
     4741 tgcccactgc cagcatttct gcagtccaac caacaagcag ctactcttta agaaaataaa
     4801 tgtgtgcaga aaccagggcg tgcgtgcgtg cgtgcgtgtg tgtgtgtgtg tgcatgtgtg
     4861 tgttgccatt gtaacacaat tccagttttt cactaaagca taccattagg caatggagtg
     4921 agcgttcctg actccggagt tatactaagg aaaagaaaat tagcccacct cactggaggc
     4981 cccaacaaga aaagaaactg gaccagacag aaaagccaaa gtggccattc ggagggagac
     5041 cctgttggta ttacggtatt gagaagacac taagctccct tcacgcagca gcctcgtggt
     5101 catcaccaac caaccaacgt gacgaatgca gtcctaatcc gtgttcgcca ggggcacctt
     5161 ggctggtcat ttcctgtagg tatgaaatgt ctggtggttt tgtgtgagct ataatttacc
     5221 tttatgttta ttccttaagt tgttttaacc cgaagtctgc aatatccaga gaaccatctc
     5281 gggtatttga gcacctatta aaggaaaggc aagcatatcc atctctctgc cttcccagtg
     5341 aagaagctga ctttctggtt tctttcttct tgcccttatc aacccaatga acgcagttct
     5401 ctgtctccga tgtcgggaga aagttctgga acttaattgc aaatatattt aaggaaagag
     5461 aagaatctaa taagcctttc aaaaaccacc aagtatggaa atgagtcgtg agtcctgaga
     5521 aaaggtcagg caggctttgt atcctgtaat taacccagcg atccattggc gcttttttaa
     5581 aaatacagga gtttgtactc gagggagaac atgggttcat ctcacatgtc cagatacgtg
     5641 caaccccaca gcaacacatg ccggacaccc gtgaccgtta ggctgtaggc acactagaaa
     5701 gaggccggtc tgccatgtag cagcggtctg tctgcatttg aacagtaaaa aatagtttcc
     5761 tcttctccat gtcttgttct aaaacatcca tcctgtgttg cttgggcttg gccctagccg
     5821 cgtattttag agacatcaac attccttagt gtatgtgaaa cgggcttaat ctaacacagg
     5881 atgtatggat ttatgtcctt ttcctcctcg gcacggcgga tttgtttatg cattcctaaa
     5941 tccccacttc acttacttat cgttacaagt acggggagct ctactgggga ggtcattttt
     6001 ccttcagggc tgtacaggac acagattgtc ccttcacccc ttaaaatgat taatcctttg
     6061 ttagtattcg ctgtctattg actggctgat atgtttttat ttaacaaaag cagaacgaac
     6121 ctttaggaga tatgtgctag aggggccaac ggggacaaaa aataagcaat tgtcaaatta
     6181 atgagaacag cttcctgaaa gaaaccatat tctcaggcaa ctcaaagtcg agctccacag
     6241 agggactcta ggtctcccta cagaggcact cggggaccaa agggtgatgg agatggaggt
     6301 gaccattctc gtttttgctt cctgtttccc ttttctaatc gttaagtcta aaacctcttt
     6361 tgaagcttga accactgttg gcatttctag aaagcaactg taataggggc tagtgctttt
     6421 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttttttag tatgactgta
     6481 ttttgttttg tttgtttgtt gaggccagct tcaccccata atttttttta aaaaaatttc
     6541 attttttaca tttaaaaaaa atgcaagttt ttttttccca aagaaatgga gagtcctgtg
     6601 gctgctatcc cggcctaatg ccagttttta accatgttgg gttgtgctgc agggaaatgc
     6661 cagttagcct gttgcttctt taacacagct gcctgtgaac aaagaagcgc tgatagatgt
     6721 ctcccggtgg gggtgctgtt ggtatttgga tctgggtaaa tccttgctgt gctgaaatgt
     6781 accacatgtt gcaagatgtt cagtatcctg ggctcctggt gactcaacac cagacattgt
     6841 gagaaccgga aaaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa
     6901 agagaagaaa aaagcttccc gtttgcctgc atagaaggat aaacccctca cctgagtgcc
     6961 actgtctcct gcaacaaggg tacatggggg aacctgcctg tctctaaata ccatgtctac
     7021 tgccttgcac gtctctaccc acttctcttt caaagccttc tgcttagatg cagcttaaac
     7081 tggcctgttc cctagaaaag agcttcctag gtagtcttgt ccattacggt gggcagcgtg
     7141 acatggcctg atatttctgg agggtacacg aagcaagtct tgttcattac ttctgtgtta
     7201 cttcagaact agactcctgg ttgccagaac acagtgtctc tgagtaaaac actggtcttt
     7261 ggaactcagc attggattct acctggtcat actgaagacc gagttgcaaa aagagtctcc
     7321 cttcctcctg ttgacaacgg agttaatcca cacaaaaaga cacggggact ccctcgtgta
     7381 aacatccaca cggttccgct ttcctaataa gacgtgcaaa tatgacatgt tggcaggaac
     7441 gtaggtaaac tggattgcat tcatgctgtt cacaccacag acgggcaaaa cgaaatgagt
     7501 tttcccccag gtgtagctcg atcaagctgt gctaaccgta cagaaagacg ctctttacgc
     7561 cactgaaatt aaatagtcag tgggtcttga aaaatattta gatgaattgc agctagctgc
     7621 aaggatggaa ttaattcctc ccattcttca cattaaaatt ctgaagactc cccgcccctc
     7681 ccccttcttt taagcatagc aacttggagt cagtaaaggt ggccatagcg taaacctata
     7741 gatggtgctt taaaacaaaa tcgtatcttt cttaatagca gtatttttta aagcagagaa
     7801 tagactgaaa gaagtaaatg cggcagaacg ctgttccaca ctcaggtaaa ttttgtggtt
     7861 tattaaaatg ccaataatat ttgtgcactt gccagcgtca ggggcttttc ccttaatgga
     7921 tgctctcggt gtgatttttt tcctcttctt taactgtatc gttacattgt ttagagagca
     7981 tccaccacca ggatttgcca ccgtagtgat aactagcatt aggaaagaat taccgagaac
     8041 tgagggtcaa accactttca tcacctaaac gacaggcact agttctttag tatttcttca
     8101 gtggcttggg tgtgcccatg tattcaaagc attccgcacg aattttacca gttaaatacc
     8161 ggctgaaaag tcagaccagt ctctctccgc acctcctctc tctgtaacaa tgtttcgttt
     8221 ttgttttgtt tttttcccat aatgagctgt ctgtgttctt ttgttatttc aaactttggt
     8281 tcaagtggta gcaatggtac acactgtgat ggtggggaga ctagctgggt gagtctctag
     8341 tgtgtgatct aatctttaca tgggtgtgct atctgtgggt gttgataact ggaactgtac
     8401 ccggacaaca cgacagtttc tctctcttcc tgttcctgat tcactactat atcatagtac
     8461 gtgggtatga cccctgcgag tatccacacc gaagcctatg tattccacaa ttgtaacctg
     8521 aaagaccatg cattatcttt ttttaattca tactggtgtt tgtgttattt aaagtggaaa
     8581 attataccct atctagtagt ataatgtaat ataataggat actccgctgt gcacagttcc
     8641 aagtgcctta gaacattgtt tagctttcct aagtatacgt aaatgcatat atgtgtgtat
     8701 aaaattggga aatgttacct caataaagtc attgggaaat ccta
//
LOCUS       NM_001437872            3947 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus growth hormone receptor (Ghr), transcript variant
            2, mRNA.
ACCESSION   NM_001437872 XM_039101770
VERSION     NM_001437872.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3947)
  AUTHORS   Klammt,J., Shen,S., Kiess,W., Kratzsch,J., Stobbe,H., Vogel,M.,
            Luo,F. and Pfaffle,R.
  TITLE     Clinical and biochemical consequences of an intragenic growth
            hormone receptor (GHR) deletion in a large Chinese pedigree
  JOURNAL   Clin Endocrinol (Oxf) 82 (3), 453-461 (2015)
   PUBMED   25196842
REFERENCE   2  (bases 1 to 3947)
  AUTHORS   Deng,H.Z., Deng,H., Cen,C.Q., Chen,K.Y. and Du,M.L.
  TITLE     Post-receptor crosstalk between growth hormone and insulin signal
            in rats born small for gestational age with catch-up growth
  JOURNAL   PLoS One 9 (6), e100459 (2014)
   PUBMED   24963636
  REMARK    GeneRIF: receptor crosstalk between growth hormone and insulin
            signal in rats born small for gestational age with catch-up growth
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3947)
  AUTHORS   Claessen,K.M., Kloppenburg,M., Kroon,H.M., Bijsterbosch,J.,
            Pereira,A.M., Romijn,J.A., van der Straaten,T., Nelissen,R.G.,
            Hofman,A., Uitterlinden,A.G., Duijnisveld,B.J., Lakenberg,N.,
            Beekman,M., van Meurs,J.B., Slagboom,P.E., Biermasz,N.R. and
            Meulenbelt,I.
  TITLE     Relationship between the functional exon 3 deleted growth hormone
            receptor polymorphism and symptomatic osteoarthritis in women
  JOURNAL   Ann Rheum Dis 73 (2), 433-436 (2014)
   PUBMED   23740230
REFERENCE   4  (bases 1 to 3947)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 3947)
  AUTHORS   Enhamre,E., Carlsson,A., Gronbladh,A., Watanabe,H., Hallberg,M. and
            Nyberg,F.
  TITLE     The expression of growth hormone receptor gene transcript in the
            prefrontal cortex is affected in male mice with diabetes-induced
            learning impairments
  JOURNAL   Neurosci Lett 523 (1), 82-86 (2012)
   PUBMED   22750159
REFERENCE   6  (bases 1 to 3947)
  AUTHORS   Frick,G.P. and Goodman,H.M.
  TITLE     Characterization of the short isoform of the growth hormone
            receptor synthesized by rat adipocytes
  JOURNAL   Endocrinology 131 (6), 3083-3090 (1992)
   PUBMED   1446642
REFERENCE   7  (bases 1 to 3947)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 3947)
  AUTHORS   Godowski,P.J., Leung,D.W., Meacham,L.R., Galgani,J.P., Hellmiss,R.,
            Keret,R., Rotwein,P.S., Parks,J.S., Laron,Z. and Wood,W.I.
  TITLE     Characterization of the human growth hormone receptor gene and
            demonstration of a partial gene deletion in two patients with
            Laron-type dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8083-8087 (1989)
   PUBMED   2813379
REFERENCE   9  (bases 1 to 3947)
  AUTHORS   Baumbach,W.R., Horner,D.L. and Logan,J.S.
  TITLE     The growth hormone-binding protein in rat serum is an alternatively
            spliced form of the rat growth hormone receptor
  JOURNAL   Genes Dev 3 (8), 1199-1205 (1989)
   PUBMED   2792761
REFERENCE   10 (bases 1 to 3947)
  AUTHORS   Mathews,L.S., Enberg,B. and Norstedt,G.
  TITLE     Regulation of rat growth hormone receptor gene expression
  JOURNAL   J Biol Chem 264 (17), 9905-9910 (1989)
   PUBMED   2722883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039101770.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.7375.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000002.1  54531313-54531352   c
            41-119              JAXUCZ010000002.1  54418526-54418604   c
            120-185             JAXUCZ010000002.1  54351981-54352046   c
            186-315             JAXUCZ010000002.1  54304431-54304560   c
            316-488             JAXUCZ010000002.1  54298368-54298540   c
            489-667             JAXUCZ010000002.1  54285767-54285945   c
            668-836             JAXUCZ010000002.1  54279713-54279881   c
            837-927             JAXUCZ010000002.1  54277635-54277725   c
            928-997             JAXUCZ010000002.1  54272313-54272382   c
            998-3947            JAXUCZ010000002.1  54269066-54272015   c
FEATURES             Location/Qualifiers
     source          1..3947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3947
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
     exon            1..40
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="upstream in-frame stop codon"
     exon            41..119
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1966
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; growth hormone receptor/binding protein; GH
                     receptor; somatotropin receptor; growth hormone receptor
                     variant d5-6"
                     /codon_start=1
                     /product="growth hormone receptor isoform 1 precursor"
                     /protein_id="NP_001424801.1"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
                     /translation="MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLR
                     ESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECP
                     DYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLL
                     NISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLY
                     SLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGI
                     FGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYK
                     PDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYD
                     PDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITL
                     TMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIK
                     AGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIY
                     ITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSS
                     CGYVSTDQLNKIMQ"
     sig_peptide     50..103
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1)"
     mat_peptide     104..1963
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /product="Growth hormone receptor. /id=PRO_0000010969"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1)"
     misc_feature    194..430
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    194..430
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    392..394
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    494..799
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    494..799
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(494..496,713..715,764..766)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(494..496,713..715,764..766)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    515..517
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    530..532
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    647..649
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    767..781
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: WSXWS motif.
                     /evidence=ECO:0000250|UniProtKB:P10912"
     misc_feature    order(767..772,776..781)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(767..772,776..781)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    845..916
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     transmembrane region"
     misc_feature    932..1189
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Required for JAK2 binding.
                     /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    941..967
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Box 1 motif. /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    998..1897
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    998..1897
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    1070..1099
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: UbE motif. /evidence=ECO:0000305|PubMed:7615519"
     misc_feature    1073..1075
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    1118..1216
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1508..1510
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    1829..1831
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     exon            120..185
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            186..315
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            316..488
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            489..667
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            668..836
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            837..927
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            928..997
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            998..3947
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagttctga tggaactgca gagtcttgag cgctgagcgg gtctcaggta tggatctttg
       61 gcgggtgttc ttaaccctgg cactggcagt ctccagcgac atgtttcctg gaagtggggc
      121 tacaccagct actcttggca aagcttcccc ggttctgcaa agaattaatc caagcctgag
      181 ggaaagttcc tctggaaagc ctcgattcac caagtgtcgt tcccctgaac tggagacctt
      241 ttcatgctac tggacagaag gggatgatca taatttaaag gtcccgggat ctattcagct
      301 atactatgct agaagaattg ctcatgaatg gaccccggaa tggaaagaat gccctgatta
      361 tgtctctgct ggagcaaaca gctgttactt caactcatcg tatacctcca tttggatacc
      421 ctactgcatt aagcttacta caaatggtga tttgttggac gaaaagtgtt tcactgttga
      481 tgaaatagtg caacctgatc cgcccattgg cctcaactgg actttactaa acatcagttt
      541 gcctgggatc cgtggagata tccaagtgag ttggcagcca ccgcccagtg ccgatgttct
      601 gaagggatgg ataattctgg agtatgaaat tcagtacaaa gaagtaaatg aaacaaaatg
      661 gaaaacgatg agcccgatat ggtcaacatc agtcccactg tactcactga gactggataa
      721 agagcacgaa gtgcgtgtga gatccagaca acggagcttc gaaaagtaca gcgagttcag
      781 tgaagtactc cgtgtaacgt ttcctcagat ggacacactg gcagcatgtg aagaagattt
      841 ccggtttcca tggttcttaa ttattatctt tggaatattt ggagtagcag tgatgctatt
      901 tgtagttata ttttcaaagc agcaaaggat taagatgctg attttacccc cagtaccagt
      961 tccaaagatt aaagggattg atccagatct tctcaaggaa ggaaaattgg aggaggtgaa
     1021 caccatcttg ggcattcatg ataactacaa acccgacttc tacaatgatg actcctgggt
     1081 tgagttcatt gagctggata ttgatgatgc ggatgagaag actgaagagt cagacaccga
     1141 cagacttcta agcgatgacc aggagaaatc agctggtatc cttggagcaa aggatgacga
     1201 ttctggacgt accagctgtt atgaccctga cattttggat accgatttcc acaccagtga
     1261 catgtgcgat ggtacctcgg agtttgctca gccgcagaag ttaaaagcag aagctgatct
     1321 cttgtgcctt gaccagaaga atctgaagaa ctcgccttat gatgcttccc ttggctctct
     1381 gcacccctcc attaccctga caatggaaga caaaccacag ccacttctgg gcagtgaaac
     1441 tgagtcaacc caccaactcc cctctacacc aatgagcagt cccgtgtcac tggcaaacat
     1501 tgacttttat gcccaagtaa gcgacattac accagcaggt ggtgtagtcc tttctccagg
     1561 ccaaaagatt aaggcagggt tagcccaggg caacacccag ctggaggtgg ccgcgccctg
     1621 ccaagaaaat tacagcatga acagtgccta cttctgtgag tcagatgcca aaaagtgcat
     1681 cgctgcggcc cctcacatgg aggccacgac atgtgtaaaa ccaagcttta accaagagga
     1741 catttacatc accacagaaa gccttaccac tactgcccga atgtccgaga cagcagatac
     1801 cgctccagat gctgagcctg tcccagacta caccacggtt cacaccgtga agtccccaag
     1861 gggccttata ctcaacgcga ctgctttgcc tttgcctgac aaaaagaagt ttctctcctc
     1921 atgtggctat gtgagcacag accaactgaa caaaatcatg cagtagcctt tcctatcttt
     1981 aatggcaaaa gaaatgactg ggcacgaacg cctaaaccaa aactatgttt taaatctgtg
     2041 ttgggagagc gtgagagtga atgtggattc aaaaatacct tttctggaaa cgtcgaaaca
     2101 ttatcataac gtggaaaatc aagaatatgt aatcagatag atactcccat tgtgaatttt
     2161 aaatatttta aagaatcgtc tttaagactg tttagtggca gtgattgtct gtgctgtggg
     2221 tcttaacttt gtgatactaa gtattaaata gctacgtttt tcatgtatgt agatcatgct
     2281 tttttgaaaa agcaaaacaa tcaggtggct tttgcagttc aggaaattga atgcagattt
     2341 tagcacagac tgatttcttt ttccttttta aatagctagg agctaaaact ctaggggaga
     2401 aggtaaaact agtttggata tgcaaaacat ttattttgac ataaaattga taaagatatt
     2461 tttaataatt tacactgtaa gcatgagtat tttataatac actacagata tattgtagtt
     2521 cacaacaatc catctacgga tgtaacaact acaatgtgta gaggggttga tgctttggtc
     2581 aatgaaccta aagaaaaatg aacaagttag atttttacaa agcccttttt tataactccc
     2641 aaaacttctt aaatctaaaa atgtctgcat tattggaaca aacccatttt aaatttgtaa
     2701 atgaatattt ttttaatttt gaaaacttta attttttata caaattaacg tatcatacac
     2761 caaacagtaa cagaagtgat tataataatg gaagaaacag tttcttcacc aaatttccat
     2821 tcaagccaca aggctgtgtg taagagaagt agaagtgatg tggtgtgact ggctaggata
     2881 aaggagatct tcaggagcac atgggtttag agagcccagg gatcaggaaa aggaggctct
     2941 cacatctgag cagtgctgtc ctttcaaaca cagcttggct tttatagtaa cctaagaatt
     3001 aatgcataca aggaggagtt tcacatgtgt gaaatccaat agcagatggg ttaaagttaa
     3061 acaagttata gcacaggaaa ttaaagacct agatctttgt ttcgcagtca gacacatact
     3121 tttaattcag ggagaaaagg gacagaataa atgacttcac agtcacaagg cacacctcag
     3181 aagtagttaa acaagtaaca gaaaccttgt tatcaaacct ttaataagat gtattttaaa
     3241 tagtaagcag tatttcattg cttcttaccc tcccagagag attgatctca aataaggtag
     3301 gaaaacaaac aatataaaaa tcactttaat tatgtaataa catagacaca gctctttggg
     3361 ttagcccccc aaaagattta tgagagaagg aggactttca gccaactgaa gaatacttct
     3421 cattttaagc actttttaga tgcttgaaac tttaaaatta cctttaactt tcaatgatat
     3481 ttaccatttt gcagagacct ttgtggggaa acaggcttaa tgtttagtgg tttttaaatc
     3541 tctttcatgc aggagagaca gtgaaaaatt tagacttggg tgtttaaggt tcactgtgtt
     3601 attctgtagt agattttaat agattttttt ctgctacctt gctgctatgg tttccccaat
     3661 ggctacatga tttagttcat atgaagtatc atcaacttag aacctattca gcttaaagat
     3721 gtgtgttttg atgaactatc ttaccatttc accataggct gaccacgttg ctatagccaa
     3781 aaatagctaa atacctcaat cagtcccaga atgtcatttt tggtactttg ctggccacac
     3841 aagccattat tcaccatgtg actagttgtg tcctgcagtc tgtatttaac tttcttttat
     3901 gtctgtggat ttttcccttc aaagttcaat aaatttattt tcttgga
//
LOCUS       NM_001024341            2822 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 6, mRNA.
ACCESSION   NM_001024341 XM_575762
VERSION     NM_001024341.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001024341.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC091289.1, SRR26360194.1205977.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2822              JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2822
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..2822
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    196..198
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             316..1416
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001019512.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    352..669
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    352..669
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    694..765
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    802..861
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    955..1074
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1015..1017
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1060..1386
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1060..1386
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1204..1206
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1252..1314
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 ctctgcctgc agttgagcac aaagacctga aggagactcc cacagccttc agggagaaga
       61 aaggaggcag ccaaggctat taaaaggaac ttgtggcttg tggccttttt gtgtaggagc
      121 agtctggaag gggagaaaag tgcaccgaag ccacagtggc ggttaatgag ctgtgagatg
      181 aggcgcagcc gcgactgaca ctgcttccag gatccttcat ctgccctttg tgcttcgtgt
      241 acatgtgtct gttcaggccg gccagaggcg cccagaagag catccaccac ggctgccggg
      301 gaaagaccgc ccaccatgcc cacggagacg ctacagacag gtagcatggt gaagcctgtc
      361 agccccgcgg gcaccttcac gtcggcggtg cccctgcgca tcctgaacaa aggacccgac
      421 tacttccgca ggcaggctga gcccaacccc aagagactca gtgcggtaga gagactagag
      481 gctgacaagg ccaaatatgt caagagccag gaagtgatca atgctaaaca ggagccagtg
      541 aagccggccg tgttggccaa gccccctgtg tgcccaggag ccaaacgagt actgggcagc
      601 cccactctca aggtgttcgg caaccatgcc aagaccgaga gcggcgtgca acgcgagacc
      661 ctcaagcttg agatcctcaa gaacatcatc aacagctcag agggctccag ctctggctct
      721 ggccacaagc atagctcccg aaactggccg cctcacaggg acaccactga gctgcaccgg
      781 cattccttcg cagagtcgct gaaggtgtac cctacacctg gccgtggcag cccgcaggag
      841 agcagctccc acgtgagcag gaggctgctg gagcagtctg cggagtcctt cctgcatgtc
      901 tcacacagct cctcagacat ccgcaaagtg accagtgtga agccccttaa agccatcccc
      961 tgcagcagtt ctgcccctcc cctgcctccc aagcccaagg tggctgctat gaagtcccct
     1021 gatgctgacc aggtggaacc agcctgtggg gtcagccgga gaccttccct tcagcggtcc
     1081 aagtcagact tgagtgacag gtatttccga gtagatgcag acgtggagag gttcttcaac
     1141 tactgtggac ttgacccaga agagctggaa aaccttggca tggagaactt tgccagggct
     1201 aattctgaca tcatatctct caacttccgc agtgcaagca tgatcagctc agactgtgaa
     1261 cagtctcagg acagtaacag tgaccttaga aatgacgaca gtgccaatga ccgggtgcca
     1321 tacggcattt ctgccatcga gagaaatgct agaatcatca agtggctgta tagcatcaaa
     1381 caagctagag agtcacagaa ggtgtcccac gtgtaagagg cgcagtggtg aaaaggaggg
     1441 ggggtgggtc tgtctgtgca tacaccgttg tgaaggttgt gaggtctcct tgaagtgtcg
     1501 tgagcttctc cactttgtgt tgcttgttgt gcaatgttct caagttgcat gcctgtcaac
     1561 atggcaactg gcctggcttc cttctcacac ctcgcagggc cttgctgaac actcatctgc
     1621 caaaagttcc cggccagaat ctgattaggg ctttgctctt aagcaaaact gtttacagaa
     1681 agaaaagaaa agaaaaaaaa aaaaaaacgg tttcgatttc ttcaatattt atgtgttttt
     1741 tgtgttttta taccctgcgc tattgtgtct taattaaaag ttttatcaac tggcttttaa
     1801 gttgagagca gaatcttttt gaaacaaaaa agccactttg cctacatggg agaccataac
     1861 actggggaaa tatatgggac ttgccaccaa atacagaatg acagccaggc tggagttcat
     1921 ttatgtgaaa tcaagtggtg ggccttgacc ttgtgcttca catgttggca ttttcttgcc
     1981 actttgtgaa gcactgtggg gcaacagtac agtcctcggt ccaattaagt gtatatgttg
     2041 gtatttttgt agaactgacc ccaggaaaga caatcagaca aaacccagga taggaggttc
     2101 tatattgatt gggaggggag ggaagggaga cagttgatgc tgttcaaagt gggataattc
     2161 ataaatatct agtattaacc ttacagaagt gccattcgac agctgattaa agctgataca
     2221 gaatgctatc tttaaaacat tatttcgttg gattttattt gttttgtgct tttggccaag
     2281 aattaactca tgttgtttct ctcccttgct cccttggtag ttgttctgtt cagggcggat
     2341 gggttggtct tctgcaggtt tgcactctga agggaggtga gaataccatc cgtgtcagta
     2401 tagtctccat tccacagtat ccacgtgctg gccgcttcac acctcagcag tgtgactctg
     2461 ttacctcgct tatactcctc tctaaagccg tgggtatttg ttagagctct agaaaactgt
     2521 agaaacaata tagctttcca ctctgttgtc tcttgttgcc tcttcccaca atagcctgcc
     2581 ctccctcggg gtcatttcag gagctgtgag ccagctgcca gcgttggcaa tggacgagga
     2641 ggacacgggt gggctgctcc actgcctcac aacccacagg ttcgcagcag aagcacctcg
     2701 gtcctcatca gctactagga gccttgaaac ggtgtgaatg ctgtaagatt ctgtacatac
     2761 ttgagttgtt ctggaatcta agaagaaagt tatgctaata aatagctctg gtgtaggctt
     2821 ta
//
LOCUS       NM_001437845            2068 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus TEA domain transcription factor 2 (Tead2),
            transcript variant 2, mRNA.
ACCESSION   NM_001437845 XM_063262029
VERSION     NM_001437845.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Tamm,C., Bower,N. and Anneren,C.
  TITLE     Regulation of mouse embryonic stem cell self-renewal by a
            Yes-YAP-TEAD2 signaling pathway downstream of LIF
  JOURNAL   J Cell Sci 124 (Pt 7), 1136-1144 (2011)
   PUBMED   21385842
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Tian,W., Yu,J., Tomchick,D.R., Pan,D. and Luo,X.
  TITLE     Structural and functional analysis of the YAP-binding domain of
            human TEAD2
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7293-7298 (2010)
   PUBMED   20368466
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Bhattaram,P., Penzo-Mendez,A., Sock,E., Colmenares,C., Kaneko,K.J.,
            Vassilev,A., Depamphilis,M.L., Wegner,M. and Lefebvre,V.
  TITLE     Organogenesis relies on SoxC transcription factors for the survival
            of neural and mesenchymal progenitors
  JOURNAL   Nat Commun 1 (1), 9 (2010)
   PUBMED   20596238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Zhang,H., Liu,C.Y., Zha,Z.Y., Zhao,B., Yao,J., Zhao,S., Xiong,Y.,
            Lei,Q.Y. and Guan,K.L.
  TITLE     TEAD transcription factors mediate the function of TAZ in cell
            growth and epithelial-mesenchymal transition
  JOURNAL   J Biol Chem 284 (20), 13355-13362 (2009)
   PUBMED   19324877
  REMARK    Erratum:[J Biol Chem. 2019 Apr 12;294(15):5808. doi:
            10.1074/jbc.AAC119.008436. PMID: 30979850]
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Zhao,B., Ye,X., Yu,J., Li,L., Li,W., Li,S., Yu,J., Lin,J.D.,
            Wang,C.Y., Chinnaiyan,A.M., Lai,Z.C. and Guan,K.L.
  TITLE     TEAD mediates YAP-dependent gene induction and growth control
  JOURNAL   Genes Dev 22 (14), 1962-1971 (2008)
   PUBMED   18579750
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Sawada,A., Nishizaki,Y., Sato,H., Yada,Y., Nakayama,R.,
            Yamamoto,S., Nishioka,N., Kondoh,H. and Sasaki,H.
  TITLE     Tead proteins activate the Foxa2 enhancer in the node in
            cooperation with a second factor
  JOURNAL   Development 132 (21), 4719-4729 (2005)
   PUBMED   16207754
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Kaneko,K.J., Rein,T., Guo,Z.S., Latham,K. and DePamphilis,M.L.
  TITLE     DNA methylation may restrict but does not determine differential
            gene expression at the Sgy/Tead2 locus during mouse development
  JOURNAL   Mol Cell Biol 24 (5), 1968-1982 (2004)
   PUBMED   14966277
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Milewski,R.C., Chi,N.C., Li,J., Brown,C., Lu,M.M. and Epstein,J.A.
  TITLE     Identification of minimal enhancer elements sufficient for Pax3
            expression in neural crest and implication of Tead2 as a regulator
            of Pax3
  JOURNAL   Development 131 (4), 829-837 (2004)
   PUBMED   14736747
  REMARK    Erratum:[Development. 2004 Mar;131(5):1195]
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Yockey,C.E. and Shimizu,N.
  TITLE     cDNA cloning and characterization of mouse DTEF-1 and ETF, members
            of the TEA/ATTS family of transcription factors
  JOURNAL   DNA Cell Biol 17 (2), 187-196 (1998)
   PUBMED   9502435
REFERENCE   10 (bases 1 to 2068)
  AUTHORS   Yasunami,M., Suzuki,K., Houtani,T., Sugimoto,T. and Ohkubo,H.
  TITLE     Molecular characterization of cDNA encoding a novel protein related
            to transcriptional enhancer factor-1 from neural precursor cells
  JOURNAL   J Biol Chem 270 (31), 18649-18654 (1995)
   PUBMED   7629195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063262029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.4192302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  104838842-104838882
            42-279              JAXUCZ010000001.1  104840316-104840553
            280-344             JAXUCZ010000001.1  104841151-104841215
            345-407             JAXUCZ010000001.1  104842308-104842370
            408-515             JAXUCZ010000001.1  104843681-104843788
            516-574             JAXUCZ010000001.1  104843887-104843945
            575-639             JAXUCZ010000001.1  104846742-104846806
            640-782             JAXUCZ010000001.1  104848502-104848644
            783-956             JAXUCZ010000001.1  104851373-104851546
            957-1118            JAXUCZ010000001.1  104853338-104853499
            1119-1267           JAXUCZ010000001.1  104854162-104854310
            1268-2068           JAXUCZ010000001.1  104854835-104855635
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2068
                     /gene="Tead2"
                     /note="TEA domain transcription factor 2"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
     exon            1..41
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            42..279
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1232
                     /gene="Tead2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Embryonic TEA domain containing factor; TEA domain family
                     member 2; transcriptional enhancer factor TEF-4"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-4 isoform 2"
                     /protein_id="NP_001424774.1"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
                     /translation="MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGV
                     WSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSS
                     HIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATEL
                     FQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAW
                     QARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYD
                     KFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESR
                     ELMTLTCSSKVCSFGKQVVEKVESGPSWRAGALCTACCALPCVSTWSTSCTSSVSCLS
                     AT"
     misc_feature    165..368
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    165..368
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    726..>1118
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     misc_feature    726..>1118
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     exon            280..344
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..515
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..574
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..639
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..782
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..956
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1118
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1267
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2068
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgccccgc ccgcccgcgg ctcccctgcc caggccggga ggcccagatg ggggatcccc
       61 ggactggggc ccccctggat gatggcgggg gctggacagg tagtgaggaa ggcagcgagg
      121 agggcactgg aggcagtgaa ggtgttggag gtgatgggag ccccgatgca gaaggtgtgt
      181 ggagccctga catcgagcag agttttcagg aggccctggc aatctaccct ccctgtggcc
      241 gtcgcaagat catcttgtca gatgagggca agatgtatgg ccggaacgaa ctcatcgccc
      301 gttacatcaa gctgaggaca gggaagacca gaactcgaaa gcaggtctct agtcacatcc
      361 aggttttggc tcgaaggaaa tcgagagaaa ttcagtccaa gctgaaggac caagtctcca
      421 aggacaaggc cttccagacg atggccacca tgtcttcggc acagctcatc tctgcacctt
      481 ctctccaggc caagctgggt ccttctggcc ctcaggccac cgagcttttc cagttctggt
      541 cagggagctc tgggccaaca tggaatgttc cagacgtgaa gcccttctca caagcaccgt
      601 tctccatgtc actgacgccc ccagccactg acctaccagg gtacgagccg cccccagccc
      661 tctcacccct acccccaccc gccccatctc ccccagcctg gcaggctcgg gccctgggca
      721 ctgcgcgcct gcagctggta gagttctcag cgtttgtgga gccgccagat gcagttgact
      781 cgttccagag gcatctgttt gtccacatca gtcagcagtg ccccagccct ggagccccac
      841 ccctggagag tgtggacgtg cggcagatct acgacaaatt ccctgagaaa aagggcggtc
      901 tccgggagct gtatgaccgg gggccaccac atgccttttt cctggtcaag ttctgggcgg
      961 acctgaactg gggcccaagt gccgaggagg cagggaacag cggaggtgct ggtggcttct
     1021 acggagtgag cagccagtac gagagccgag agctcatgac actgacctgc tcctccaagg
     1081 tctgctcctt tggcaagcaa gtggtggaga aggtggagag cgggcccagc tggagggcgg
     1141 gcgctttgtg taccgcctgc tgcgctctcc catgtgtgag tacctggtca acttcctgca
     1201 caagctccgt cagctgcctg agcgctacat gatgaacagc gtcctggaga acttcaccat
     1261 cctccaggtt gtgacaaata gggacactca ggaactgctg ctgtgtactg cctacgtctt
     1321 tgaagtctcc accagtgaac gcggagccca gcaccacatc taccgcctgg tcagggactg
     1381 atggggcccc attgctgctg tttatccgaa cacccccttc ctaggaaggg cccttctgct
     1441 ctccctgtaa gagagatgtg gagaggggcc catgattttt aaaaaggcct catctcagaa
     1501 gcaatggggg ctggcttcta ttagaaaggc acccgaagct tggcagcgaa gggagctggg
     1561 tttgagttta gatccccaac acgaggacct cacagagaac ctttgacagg acacaccact
     1621 cctgagcatc agggattgag gataggagtg catgcgcaca ggtacgcggc ctctccactc
     1681 tacaggggcc cctccttgct cttctggaaa ggggagctca gctatgtggg gcctcttact
     1741 cattgcctta tacccttcct gttttccagt ggtctcatgt ctgcccctcc cccacaccct
     1801 ttctctggga tctgtaatgt tacaaaccga agataatggt ttcccagctt gaggtagagt
     1861 gaagtgggac ctgaaaaatt gttttaatat aaggagatat ttatacacag tgttagggat
     1921 gtaatcttat ctcagctagg cagtggggtg ggacttctta atctcccccc accccattca
     1981 agtgagccgt ggaccaccct gccaccttcc cttccccaag agtgatggtt tatgtttgaa
     2041 ggagaataaa actattttta ccaaaaaa
//
LOCUS       NM_001437886            2959 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 5, mRNA.
ACCESSION   NM_001437886 XM_063288187
VERSION     NM_001437886.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2959)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288187.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.485321.1,
                                           SRR26360186.767589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000005.1  23587082-23587218
            138-2959            JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..2959
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2959
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..137
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            138..2959
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    333..335
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             453..1553
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001424815.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    489..806
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    489..806
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    831..902
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    939..998
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1092..1211
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1152..1154
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1197..1523
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1197..1523
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1341..1343
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1389..1451
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 actccgagcc ggcggcgagg actcggcggc cacttcatcc tggcctgtag tgcctcgcgg
       61 tccccaagct cctcctcgcg gtctccgaag ccttgtgcct ggcctggacg ctttgcaggg
      121 accggagcgc gaccaagctc tgcctgcagt tgagcacaaa gacctgaagg agactcccac
      181 agccttcagg gagaagaaag gaggcagcca aggctattaa aaggaacttg tggcttgtgg
      241 cctttttgtg taggagcagt ctggaagggg agaaaagtgc accgaagcca cagtggcggt
      301 taatgagctg tgagatgagg cgcagccgcg actgacactg cttccaggat ccttcatctg
      361 ccctttgtgc ttcgtgtaca tgtgtctgtt caggccggcc agaggcgccc agaagagcat
      421 ccaccacggc tgccggggaa agaccgccca ccatgcccac ggagacgcta cagacaggta
      481 gcatggtgaa gcctgtcagc cccgcgggca ccttcacgtc ggcggtgccc ctgcgcatcc
      541 tgaacaaagg acccgactac ttccgcaggc aggctgagcc caaccccaag agactcagtg
      601 cggtagagag actagaggct gacaaggcca aatatgtcaa gagccaggaa gtgatcaatg
      661 ctaaacagga gccagtgaag ccggccgtgt tggccaagcc ccctgtgtgc ccaggagcca
      721 aacgagtact gggcagcccc actctcaagg tgttcggcaa ccatgccaag accgagagcg
      781 gcgtgcaacg cgagaccctc aagcttgaga tcctcaagaa catcatcaac agctcagagg
      841 gctccagctc tggctctggc cacaagcata gctcccgaaa ctggccgcct cacagggaca
      901 ccactgagct gcaccggcat tccttcgcag agtcgctgaa ggtgtaccct acacctggcc
      961 gtggcagccc gcaggagagc agctcccacg tgagcaggag gctgctggag cagtctgcgg
     1021 agtccttcct gcatgtctca cacagctcct cagacatccg caaagtgacc agtgtgaagc
     1081 cccttaaagc catcccctgc agcagttctg cccctcccct gcctcccaag cccaaggtgg
     1141 ctgctatgaa gtcccctgat gctgaccagg tggaaccagc ctgtggggtc agccggagac
     1201 cttcccttca gcggtccaag tcagacttga gtgacaggta tttccgagta gatgcagacg
     1261 tggagaggtt cttcaactac tgtggacttg acccagaaga gctggaaaac cttggcatgg
     1321 agaactttgc cagggctaat tctgacatca tatctctcaa cttccgcagt gcaagcatga
     1381 tcagctcaga ctgtgaacag tctcaggaca gtaacagtga ccttagaaat gacgacagtg
     1441 ccaatgaccg ggtgccatac ggcatttctg ccatcgagag aaatgctaga atcatcaagt
     1501 ggctgtatag catcaaacaa gctagagagt cacagaaggt gtcccacgtg taagaggcgc
     1561 agtggtgaaa aggagggggg gtgggtctgt ctgtgcatac accgttgtga aggttgtgag
     1621 gtctccttga agtgtcgtga gcttctccac tttgtgttgc ttgttgtgca atgttctcaa
     1681 gttgcatgcc tgtcaacatg gcaactggcc tggcttcctt ctcacacctc gcagggcctt
     1741 gctgaacact catctgccaa aagttcccgg ccagaatctg attagggctt tgctcttaag
     1801 caaaactgtt tacagaaaga aaagaaaaga aaaaaaaaaa aaaacggttt cgatttcttc
     1861 aatatttatg tgttttttgt gtttttatac cctgcgctat tgtgtcttaa ttaaaagttt
     1921 tatcaactgg cttttaagtt gagagcagaa tctttttgaa acaaaaaagc cactttgcct
     1981 acatgggaga ccataacact ggggaaatat atgggacttg ccaccaaata cagaatgaca
     2041 gccaggctgg agttcattta tgtgaaatca agtggtgggc cttgaccttg tgcttcacat
     2101 gttggcattt tcttgccact ttgtgaagca ctgtggggca acagtacagt cctcggtcca
     2161 attaagtgta tatgttggta tttttgtaga actgacccca ggaaagacaa tcagacaaaa
     2221 cccaggatag gaggttctat attgattggg aggggaggga agggagacag ttgatgctgt
     2281 tcaaagtggg ataattcata aatatctagt attaacctta cagaagtgcc attcgacagc
     2341 tgattaaagc tgatacagaa tgctatcttt aaaacattat ttcgttggat tttatttgtt
     2401 ttgtgctttt ggccaagaat taactcatgt tgtttctctc ccttgctccc ttggtagttg
     2461 ttctgttcag ggcggatggg ttggtcttct gcaggtttgc actctgaagg gaggtgagaa
     2521 taccatccgt gtcagtatag tctccattcc acagtatcca cgtgctggcc gcttcacacc
     2581 tcagcagtgt gactctgtta cctcgcttat actcctctct aaagccgtgg gtatttgtta
     2641 gagctctaga aaactgtaga aacaatatag ctttccactc tgttgtctct tgttgcctct
     2701 tcccacaata gcctgccctc cctcggggtc atttcaggag ctgtgagcca gctgccagcg
     2761 ttggcaatgg acgaggagga cacgggtggg ctgctccact gcctcacaac ccacaggttc
     2821 gcagcagaag cacctcggtc ctcatcagct actaggagcc ttgaaacggt gtgaatgctg
     2881 taagattctg tacatacttg agttgttctg gaatctaaga agaaagttat gctaataaat
     2941 agctctggtg taggcttta
//
LOCUS       NM_001437835            3901 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 4, mRNA.
ACCESSION   NM_001437835 XM_063281279
VERSION     NM_001437835.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3901)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 3901)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 3901)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3901)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 3901)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 3901)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 3901)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 3901)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 3901)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 3901)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063281279.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.471440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217877711-217877783
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1502           JAXUCZ010000002.1  217914468-217914509
            1503-1551           JAXUCZ010000002.1  217916935-217916983
            1552-1627           JAXUCZ010000002.1  217946550-217946625
            1628-1722           JAXUCZ010000002.1  217955065-217955159
            1723-1951           JAXUCZ010000002.1  217957098-217957326
            1952-3901           JAXUCZ010000002.1  217959949-217961898
FEATURES             Location/Qualifiers
     source          1..3901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..3901
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..2000
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 4 is encoded by transcript variant 4;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 4"
                     /protein_id="NP_001424764.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPINYWTDVPCKRQLLLAN"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1371..1373
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1425..1541
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1509..1511
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1515..1517
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1527..1529
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1502
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1551
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1627
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1722
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1951
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3901
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgcattcag cagatcctgg
      781 aggctgtgct acactgccat cagatgggcg tagtccatcg ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagccccaaa ctactgtaat ccacaaccct gatggaaaca
     1501 aggagtcaac tgagagctca aataccacca ttgaggatga agacgtgaaa gcacgaaagc
     1561 aagagatcat caaagtcact gagcagctga ttgaagctat caacaatggg gacttcgagg
     1621 cttacacgaa aatctgtgat ccaggcctca ctgcctttga acccgaagca ttgggcaact
     1681 tagtggaagg gatggacttt cacagattct actttgaaaa tgctttgccc aaaatcaata
     1741 aaccaatcca cactatcatc ctgaaccctc acgtacacct ggtaggggat gatgcagcct
     1801 gcatagcata cattcggctc acacagtaca tggatggaaa tggaatgcca aagacaatgc
     1861 agtcagaaga gactcgagtg tggcaccgcc gtgatgggaa gtggcagaat attcactttc
     1921 atcgttcggg gtccccaaca gtccccatca actactggac ggatgttcca tgcaaacgtc
     1981 agttactgct ggcaaactaa agagggagct ccgacaagaa aactccgcaa tactccaagt
     2041 tcagctgatc catcaggttt ctctgtggat gccaagattc aaaagacttc ataaaattac
     2101 tgttcaatga atgacagtgt gtaagaggaa aggaaatctt tcaagaatgc tgccattaat
     2161 ctatttgggc ttctcattgg gattttgggg ttgatttttt tttcattttt taaggcaaat
     2221 atatatatat atatatatat atatatatat atatatatat atatatatat gccttcagtt
     2281 cctggtagaa atgaatggat gccttttctc tgaaagtgtt ggtgttggat aaatggatgg
     2341 ctatgtgagc caagtcctgg gtgattgtag gagcaagaat cgtttgctgt tctaccatca
     2401 aagccatgtt gatttgggtc gagctctgta tactggaaaa attcacatca ttttctagtt
     2461 tgattgcttt cagataggca cagttctggt gaatgcttgg cactgatctt ggtttttctt
     2521 tcctaaatct gtgttctgtt ttcattatat actatttgct cctttccttt gtatttgttt
     2581 tcttttccca ctcttttctt tatctttctc tctcccactt tctttctttt ttatgttttc
     2641 ctttctatag ctgatagtgt gtaaaaacag taacatttgc atatgaagtt aaaataaaaa
     2701 tcaaggtctt ctagaagcta aaactagcac ttccggtctc tcacggggct gtggagttgt
     2761 tagaagattt aaataaatac ttaaataaga gaggaatgaa ttcagcttag gttaccactt
     2821 gtgcataggt atccttgctc tgttgaaagt gttggaattg ttgagactta agctaacagc
     2881 agtaagagcc tgcttacaca gtcctggttc tccccaacta gatattgaag accaagtgga
     2941 gcctgaccag ggttgcatgc agagcacttg ttttggacct tccagactag gaggcattta
     3001 ctgcctcact ttcactagct agccacagga agagtgttct ccatcctcct agaggttgaa
     3061 cttgaccttc gtgactagtg cagttctagc ttctctcttg agtcacagta gcatcctgat
     3121 gccaggagtt aggcttttgt ccagattaaa acaacgagga aaaggaaatg ccccagtttt
     3181 ctttccgttt cccatttctt ctttgtcgat tcggtccctg ggagactgtt tctccgcgct
     3241 gaactgcttt atggtgcatg gaatctccat cagcgtactt ctaccctagc cactcacact
     3301 ccttagaagc tgatttttaa agcagaagca aggaagcaaa agtaaaacac tcccttcccc
     3361 tctttttcct catttcacct tttggtgttg attgctaatc actttagata tattgttgct
     3421 agtgaatgta tgatagatgg gttgaagctt ttctgataat tagcacatga tttaaaacaa
     3481 tatatattta aaacaaatat atacagtaca tgtattgagc cgtgttaacc tgccaatgag
     3541 atctgtgaaa aacgtaatgg cctcactttt ccctttgaat ttcttttacc tttctgtgaa
     3601 gcagctctgc gtggcataca tgtatttaaa aacacaaata gtggtagaat gggttttttt
     3661 tttacacttt taacttagca tgtggtgttg aagtattacc atagatccag tttgtcttct
     3721 gcactaagat gtgaggaaat cgtgatttgt tctctccagc acagtggaat tacaccttca
     3781 tcatcttcta ttgttttgaa aacactgcag tttaccatgg gacactgtat ataattcttg
     3841 ccgtaatggt aaatgacaaa ttgatatatt taagagttaa taaatttgtg atttctgctg
     3901 a
//
LOCUS       NM_001437830            2849 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            8, mRNA.
ACCESSION   NM_001437830
VERSION     NM_001437830.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2849)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2849)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2849)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2849)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2849)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2849)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1742.1,
                                           SRR26643292.2164.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000001.1  105324846-105325054 c
            210-681             JAXUCZ010000001.1  105320341-105320812 c
            682-831             JAXUCZ010000001.1  105319532-105319681 c
            832-926             JAXUCZ010000001.1  105319331-105319425 c
            927-2849            JAXUCZ010000001.1  105317326-105319248 c
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2849
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..209
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..681
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    261..263
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             276..1061
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 2 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 2"
                     /protein_id="NP_001424759.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGYVDCC"
     misc_feature    <729..>1019
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <729..>1019
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            682..831
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..926
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..2849
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggaga ggctggacca ggagctgacc acaagccaag
      241 agtctagaag tgcttgggac tgaaccaagg tcgtcatggc cccaccacca ctactgccag
      301 tggctgccag cactccgatc ctgcacggcg agtttggttc ctacccagcc catggcccca
      361 ggtttgccct caccctcacg acacaagccc tacacataca gcgactgcgc ccaaagccag
      421 aagcccggcc ccgagatggt ctagtccctc tggacgaggt ctcaggctgt ggcactctgc
      481 agagccgtag ccccgaagac actgcagcct acttctgcat ctacacctac ccacgtggcc
      541 ggcgtggggg ccggcgcaga gctactcgta ccttccgggc cgacggggcc gccacttatg
      601 tggagaatcg tgcagaggcc cagcgttggg caactgctct catgtgtctc ctccgaggag
      661 tgcctctgtc tggggaccag gaaatcaccc ctgaattgct gccccggaag cccaggctgc
      721 tcctattggt caatcctttt ggggggcggg gcctggcctg gcagcgctgt atggaccacg
      781 tggtgcccat gatctctgaa gctgggctgt ccttcaacct catacagaca gaacgacaaa
      841 accatgcacg tgagctggtg caggggttga gcctgagtga gtgggaaggc attgtcactg
      901 tgtccggaga tgggctgctt tatgaggtgc tgaatgggct cctcgaccgc ccagattggg
      961 aagacgctgt gcggatgccc attggtgtcc tcccctgtgg ttcgggcaat gcactagctg
     1021 gggcagttaa ccatcatggc gggtatgttg actgctgctg agacagctag ggatacctgc
     1081 taaagagagg gatgagtctt tgggacttca gggtctgata tcttattatc cagcacccac
     1141 taccccttac ccaagagcaa gttctgtggc tggcctgtag aatatcttca gtcagggatg
     1201 cttatggggg gctccaggtt atgactcctg gtggcaggca ttgctgcgcc tgccaccctt
     1261 tcccctctgt gtctcactcc tcattgccct ttcccattgt gacacctctc tctgattgtg
     1321 aaggtttgag caaactgttg gtgttgacct gttgctcaac tgctcgcttc ttctctgccg
     1381 gggtggcagc catcctctgg acctgctctc tgtgacgcta gcctcaggat cccgctgttt
     1441 ttccttcctg tcagttgcct ggggattctt gtcagatgtg gacattcaca gcgagcgctt
     1501 cagagccctg ggcagtgctc gattcacact gggtgcagtg ctaggcctgg ccacattgca
     1561 tacctaccgt ggacgtctct cctacctccc tgctaccaca gaaccagcct tgcccatccc
     1621 aggccatggt ctgccaagag ccaagtcaga actagccttg gccccagccc cagccccagc
     1681 cgccacccac tcacctcttc atcgatctgt gtctgacctg cccctgcctc ttccccagcc
     1741 tgccctggcc tcccctggct cccctgagcc cctgcctgac ctgtccctca atggtggtgg
     1801 tccagagctg actggagact gggggggagc tggggatgca cctttgtccc cagacccatt
     1861 gctgccttca tcccccaacg ctttcaaaac agctcagctt tcacccatcg ccgaagggcc
     1921 ctcagaaatg ccagcatcag ggctgctgcc tcccatccac aatgctccag aagcctctac
     1981 ctggggccca gcggaccacc tgctccctcc cctgggctct ccactgcccc aagactgggt
     2041 gacaatagag ggggagtttg tactcatgtt ggccatcttg ccaagccacc tctgcgcaga
     2101 cctgatggca gccccacacg cgcgttttga cgatggtgtg gtgcacctgt gctgggtgcg
     2161 gagcggcatc tcacgggccg cacttctacg aattttgctg gccatggaac atggaaacca
     2221 cttcagcctg ggctgcccac atctgggcta tgctgcagca cgtgccttcc gccttgagcc
     2281 actcacgcct cgtggggtgc tcactgtaga tggggaatta gtagagtatg ggccaataca
     2341 ggcacaggtg catccaagtc tcgccacact gctcactggg cctgcaggtc aaaagcctcg
     2401 agcctgaatg agcccaaagc atgccaagtt gatgggacca gagccccata ggctaaggtc
     2461 taccttttat aggtagaagt ggggcctgaa ctcagaactg caagggtaga gagtgctcca
     2521 gaccctcagt tcccagagga ccctagaggc tcgagggtgg gatctgcctt tcttgatgtc
     2581 caatgatggg gcctggaatg tatgagctag caaggcttct tcagcttact gtccagtcag
     2641 ggtttcttct tgcctatttc ggtgcctcta cttgactggc caatcagccc ttgaggggca
     2701 ggttccccca ggtggtccct agatttgcac taatgttccc ctggccagtt aggggtggga
     2761 tgttctgtgt cttgtgtgtc cctgtcccta gtctaaaaag caattgaaaa ggtctatgca
     2821 ataaaggtgt tgctttctct ggacctgca
//
LOCUS       NM_017094               4002 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus growth hormone receptor (Ghr), transcript variant
            1, mRNA.
ACCESSION   NM_017094
VERSION     NM_017094.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Klammt,J., Shen,S., Kiess,W., Kratzsch,J., Stobbe,H., Vogel,M.,
            Luo,F. and Pfaffle,R.
  TITLE     Clinical and biochemical consequences of an intragenic growth
            hormone receptor (GHR) deletion in a large Chinese pedigree
  JOURNAL   Clin Endocrinol (Oxf) 82 (3), 453-461 (2015)
   PUBMED   25196842
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Deng,H.Z., Deng,H., Cen,C.Q., Chen,K.Y. and Du,M.L.
  TITLE     Post-receptor crosstalk between growth hormone and insulin signal
            in rats born small for gestational age with catch-up growth
  JOURNAL   PLoS One 9 (6), e100459 (2014)
   PUBMED   24963636
  REMARK    GeneRIF: receptor crosstalk between growth hormone and insulin
            signal in rats born small for gestational age with catch-up growth
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Claessen,K.M., Kloppenburg,M., Kroon,H.M., Bijsterbosch,J.,
            Pereira,A.M., Romijn,J.A., van der Straaten,T., Nelissen,R.G.,
            Hofman,A., Uitterlinden,A.G., Duijnisveld,B.J., Lakenberg,N.,
            Beekman,M., van Meurs,J.B., Slagboom,P.E., Biermasz,N.R. and
            Meulenbelt,I.
  TITLE     Relationship between the functional exon 3 deleted growth hormone
            receptor polymorphism and symptomatic osteoarthritis in women
  JOURNAL   Ann Rheum Dis 73 (2), 433-436 (2014)
   PUBMED   23740230
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Enhamre,E., Carlsson,A., Gronbladh,A., Watanabe,H., Hallberg,M. and
            Nyberg,F.
  TITLE     The expression of growth hormone receptor gene transcript in the
            prefrontal cortex is affected in male mice with diabetes-induced
            learning impairments
  JOURNAL   Neurosci Lett 523 (1), 82-86 (2012)
   PUBMED   22750159
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Frick,G.P. and Goodman,H.M.
  TITLE     Characterization of the short isoform of the growth hormone
            receptor synthesized by rat adipocytes
  JOURNAL   Endocrinology 131 (6), 3083-3090 (1992)
   PUBMED   1446642
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Godowski,P.J., Leung,D.W., Meacham,L.R., Galgani,J.P., Hellmiss,R.,
            Keret,R., Rotwein,P.S., Parks,J.S., Laron,Z. and Wood,W.I.
  TITLE     Characterization of the human growth hormone receptor gene and
            demonstration of a partial gene deletion in two patients with
            Laron-type dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8083-8087 (1989)
   PUBMED   2813379
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Baumbach,W.R., Horner,D.L. and Logan,J.S.
  TITLE     The growth hormone-binding protein in rat serum is an alternatively
            spliced form of the rat growth hormone receptor
  JOURNAL   Genes Dev 3 (8), 1199-1205 (1989)
   PUBMED   2792761
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Mathews,L.S., Enberg,B. and Norstedt,G.
  TITLE     Regulation of rat growth hormone receptor gene expression
  JOURNAL   J Biol Chem 264 (17), 9905-9910 (1989)
   PUBMED   2722883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_017094.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000002.1  54431902-54431996   c
            96-174              JAXUCZ010000002.1  54418526-54418604   c
            175-240             JAXUCZ010000002.1  54351981-54352046   c
            241-370             JAXUCZ010000002.1  54304431-54304560   c
            371-543             JAXUCZ010000002.1  54298368-54298540   c
            544-722             JAXUCZ010000002.1  54285767-54285945   c
            723-891             JAXUCZ010000002.1  54279713-54279881   c
            892-982             JAXUCZ010000002.1  54277635-54277725   c
            983-1052            JAXUCZ010000002.1  54272313-54272382   c
            1053-4002           JAXUCZ010000002.1  54269066-54272015   c
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4002
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
     exon            1..95
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    51..53
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="upstream in-frame stop codon"
     exon            96..174
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2021
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; growth hormone receptor/binding protein; GH
                     receptor; somatotropin receptor; growth hormone receptor
                     variant d5-6"
                     /codon_start=1
                     /product="growth hormone receptor isoform 1 precursor"
                     /protein_id="NP_058790.1"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
                     /translation="MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLR
                     ESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECP
                     DYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLL
                     NISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLY
                     SLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGI
                     FGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYK
                     PDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYD
                     PDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITL
                     TMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIK
                     AGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIY
                     ITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSS
                     CGYVSTDQLNKIMQ"
     sig_peptide     105..158
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1)"
     mat_peptide     159..2018
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /product="Growth hormone receptor. /id=PRO_0000010969"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1)"
     misc_feature    249..485
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    249..485
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    447..449
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    549..854
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    549..854
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(549..551,768..770,819..821)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(549..551,768..770,819..821)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    570..572
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    585..587
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    702..704
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    822..836
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: WSXWS motif.
                     /evidence=ECO:0000250|UniProtKB:P10912"
     misc_feature    order(822..827,831..836)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(822..827,831..836)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    900..971
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     transmembrane region"
     misc_feature    987..1244
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Required for JAK2 binding.
                     /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    996..1022
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Box 1 motif. /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    1053..1952
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    1053..1952
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    1125..1154
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: UbE motif. /evidence=ECO:0000305|PubMed:7615519"
     misc_feature    1128..1130
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    1173..1271
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1563..1565
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    1884..1886
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     exon            175..240
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            241..370
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            371..543
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            544..722
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            723..891
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            892..982
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1052
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..4002
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctacagacc aagacaccaa gaaataacca cgaaattcta ctttcaaccc tagcttctct
       61 accagatttt aactaaacaa gatcttcttg caaaggtctc aggtatggat ctttggcggg
      121 tgttcttaac cctggcactg gcagtctcca gcgacatgtt tcctggaagt ggggctacac
      181 cagctactct tggcaaagct tccccggttc tgcaaagaat taatccaagc ctgagggaaa
      241 gttcctctgg aaagcctcga ttcaccaagt gtcgttcccc tgaactggag accttttcat
      301 gctactggac agaaggggat gatcataatt taaaggtccc gggatctatt cagctatact
      361 atgctagaag aattgctcat gaatggaccc cggaatggaa agaatgccct gattatgtct
      421 ctgctggagc aaacagctgt tacttcaact catcgtatac ctccatttgg ataccctact
      481 gcattaagct tactacaaat ggtgatttgt tggacgaaaa gtgtttcact gttgatgaaa
      541 tagtgcaacc tgatccgccc attggcctca actggacttt actaaacatc agtttgcctg
      601 ggatccgtgg agatatccaa gtgagttggc agccaccgcc cagtgccgat gttctgaagg
      661 gatggataat tctggagtat gaaattcagt acaaagaagt aaatgaaaca aaatggaaaa
      721 cgatgagccc gatatggtca acatcagtcc cactgtactc actgagactg gataaagagc
      781 acgaagtgcg tgtgagatcc agacaacgga gcttcgaaaa gtacagcgag ttcagtgaag
      841 tactccgtgt aacgtttcct cagatggaca cactggcagc atgtgaagaa gatttccggt
      901 ttccatggtt cttaattatt atctttggaa tatttggagt agcagtgatg ctatttgtag
      961 ttatattttc aaagcagcaa aggattaaga tgctgatttt acccccagta ccagttccaa
     1021 agattaaagg gattgatcca gatcttctca aggaaggaaa attggaggag gtgaacacca
     1081 tcttgggcat tcatgataac tacaaacccg acttctacaa tgatgactcc tgggttgagt
     1141 tcattgagct ggatattgat gatgcggatg agaagactga agagtcagac accgacagac
     1201 ttctaagcga tgaccaggag aaatcagctg gtatccttgg agcaaaggat gacgattctg
     1261 gacgtaccag ctgttatgac cctgacattt tggataccga tttccacacc agtgacatgt
     1321 gcgatggtac ctcggagttt gctcagccgc agaagttaaa agcagaagct gatctcttgt
     1381 gccttgacca gaagaatctg aagaactcgc cttatgatgc ttcccttggc tctctgcacc
     1441 cctccattac cctgacaatg gaagacaaac cacagccact tctgggcagt gaaactgagt
     1501 caacccacca actcccctct acaccaatga gcagtcccgt gtcactggca aacattgact
     1561 tttatgccca agtaagcgac attacaccag caggtggtgt agtcctttct ccaggccaaa
     1621 agattaaggc agggttagcc cagggcaaca cccagctgga ggtggccgcg ccctgccaag
     1681 aaaattacag catgaacagt gcctacttct gtgagtcaga tgccaaaaag tgcatcgctg
     1741 cggcccctca catggaggcc acgacatgtg taaaaccaag ctttaaccaa gaggacattt
     1801 acatcaccac agaaagcctt accactactg cccgaatgtc cgagacagca gataccgctc
     1861 cagatgctga gcctgtccca gactacacca cggttcacac cgtgaagtcc ccaaggggcc
     1921 ttatactcaa cgcgactgct ttgcctttgc ctgacaaaaa gaagtttctc tcctcatgtg
     1981 gctatgtgag cacagaccaa ctgaacaaaa tcatgcagta gcctttccta tctttaatgg
     2041 caaaagaaat gactgggcac gaacgcctaa accaaaacta tgttttaaat ctgtgttggg
     2101 agagcgtgag agtgaatgtg gattcaaaaa taccttttct ggaaacgtcg aaacattatc
     2161 ataacgtgga aaatcaagaa tatgtaatca gatagatact cccattgtga attttaaata
     2221 ttttaaagaa tcgtctttaa gactgtttag tggcagtgat tgtctgtgct gtgggtctta
     2281 actttgtgat actaagtatt aaatagctac gtttttcatg tatgtagatc atgctttttt
     2341 gaaaaagcaa aacaatcagg tggcttttgc agttcaggaa attgaatgca gattttagca
     2401 cagactgatt tctttttcct ttttaaatag ctaggagcta aaactctagg ggagaaggta
     2461 aaactagttt ggatatgcaa aacatttatt ttgacataaa attgataaag atatttttaa
     2521 taatttacac tgtaagcatg agtattttat aatacactac agatatattg tagttcacaa
     2581 caatccatct acggatgtaa caactacaat gtgtagaggg gttgatgctt tggtcaatga
     2641 acctaaagaa aaatgaacaa gttagatttt tacaaagccc ttttttataa ctcccaaaac
     2701 ttcttaaatc taaaaatgtc tgcattattg gaacaaaccc attttaaatt tgtaaatgaa
     2761 tattttttta attttgaaaa ctttaatttt ttatacaaat taacgtatca tacaccaaac
     2821 agtaacagaa gtgattataa taatggaaga aacagtttct tcaccaaatt tccattcaag
     2881 ccacaaggct gtgtgtaaga gaagtagaag tgatgtggtg tgactggcta ggataaagga
     2941 gatcttcagg agcacatggg tttagagagc ccagggatca ggaaaaggag gctctcacat
     3001 ctgagcagtg ctgtcctttc aaacacagct tggcttttat agtaacctaa gaattaatgc
     3061 atacaaggag gagtttcaca tgtgtgaaat ccaatagcag atgggttaaa gttaaacaag
     3121 ttatagcaca ggaaattaaa gacctagatc tttgtttcgc agtcagacac atacttttaa
     3181 ttcagggaga aaagggacag aataaatgac ttcacagtca caaggcacac ctcagaagta
     3241 gttaaacaag taacagaaac cttgttatca aacctttaat aagatgtatt ttaaatagta
     3301 agcagtattt cattgcttct taccctccca gagagattga tctcaaataa ggtaggaaaa
     3361 caaacaatat aaaaatcact ttaattatgt aataacatag acacagctct ttgggttagc
     3421 cccccaaaag atttatgaga gaaggaggac tttcagccaa ctgaagaata cttctcattt
     3481 taagcacttt ttagatgctt gaaactttaa aattaccttt aactttcaat gatatttacc
     3541 attttgcaga gacctttgtg gggaaacagg cttaatgttt agtggttttt aaatctcttt
     3601 catgcaggag agacagtgaa aaatttagac ttgggtgttt aaggttcact gtgttattct
     3661 gtagtagatt ttaatagatt tttttctgct accttgctgc tatggtttcc ccaatggcta
     3721 catgatttag ttcatatgaa gtatcatcaa cttagaacct attcagctta aagatgtgtg
     3781 ttttgatgaa ctatcttacc atttcaccat aggctgacca cgttgctata gccaaaaata
     3841 gctaaatacc tcaatcagtc ccagaatgtc atttttggta ctttgctggc cacacaagcc
     3901 attattcacc atgtgactag ttgtgtcctg cagtctgtat ttaactttct tttatgtctg
     3961 tggatttttc ccttcaaagt tcaataaatt tattttcttg ga
//
LOCUS       NM_001437829            2610 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            7, mRNA.
ACCESSION   NM_001437829
VERSION     NM_001437829.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1798370.1,
                                           SRR21887623.1798373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000001.1  105324846-105325054 c
            210-251             JAXUCZ010000001.1  105323321-105323362 c
            252-723             JAXUCZ010000001.1  105320341-105320812 c
            724-873             JAXUCZ010000001.1  105319532-105319681 c
            874-968             JAXUCZ010000001.1  105319331-105319425 c
            969-1084            JAXUCZ010000001.1  105319133-105319248 c
            1085-2610           JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2610
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..209
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..251
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..723
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    303..305
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             318..2168
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424758.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <771..2138
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <771..2138
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            724..873
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..968
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1084
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2610
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggagg caggctgctg aggctatcca gggcgaggtc
      241 acttgtcttg gaggctggac caggagctga ccacaagcca agagtctaga agtgcttggg
      301 actgaaccaa ggtcgtcatg gccccaccac cactactgcc agtggctgcc agcactccga
      361 tcctgcacgg cgagtttggt tcctacccag cccatggccc caggtttgcc ctcaccctca
      421 cgacacaagc cctacacata cagcgactgc gcccaaagcc agaagcccgg ccccgagatg
      481 gtctagtccc tctggacgag gtctcaggct gtggcactct gcagagccgt agccccgaag
      541 acactgcagc ctacttctgc atctacacct acccacgtgg ccggcgtggg ggccggcgca
      601 gagctactcg taccttccgg gccgacgggg ccgccactta tgtggagaat cgtgcagagg
      661 cccagcgttg ggcaactgct ctcatgtgtc tcctccgagg agtgcctctg tctggggacc
      721 aggaaatcac ccctgaattg ctgccccgga agcccaggct gctcctattg gtcaatcctt
      781 ttggggggcg gggcctggcc tggcagcgct gtatggacca cgtggtgccc atgatctctg
      841 aagctgggct gtccttcaac ctcatacaga cagaacgaca aaaccatgca cgtgagctgg
      901 tgcaggggtt gagcctgagt gagtgggaag gcattgtcac tgtgtccgga gatgggctgc
      961 tttatgaggt gctgaatggg ctcctcgacc gcccagattg ggaagacgct gtgcggatgc
     1021 ccattggtgt cctcccctgt ggttcgggca atgcactagc tggggcagtt aaccatcatg
     1081 gcgggtttga gcaaactgtt ggtgttgacc tgttgctcaa ctgctcgctt cttctctgcc
     1141 ggggtggcag ccatcctctg gacctgctct ctgtgacgct agcctcagga tcccgctgtt
     1201 tttccttcct gtcagttgcc tggggattct tgtcagatgt ggacattcac agcgagcgct
     1261 tcagagccct gggcagtgct cgattcacac tgggtgcagt gctaggcctg gccacattgc
     1321 atacctaccg tggacgtctc tcctacctcc ctgctaccac agaaccagcc ttgcccatcc
     1381 caggccatgg tctgccaaga gccaagtcag aactagcctt ggccccagcc ccagccccag
     1441 ccgccaccca ctcacctctt catcgatctg tgtctgacct gcccctgcct cttccccagc
     1501 ctgccctggc ctcccctggc tcccctgagc ccctgcctga cctgtccctc aatggtggtg
     1561 gtccagagct gactggagac tgggggggag ctggggatgc acctttgtcc ccagacccat
     1621 tgctgccttc atcccccaac gctttcaaaa cagctcagct ttcacccatc gccgaagggc
     1681 cctcagaaat gccagcatca gggctgctgc ctcccatcca caatgctcca gaagcctcta
     1741 cctggggccc agcggaccac ctgctccctc ccctgggctc tccactgccc caagactggg
     1801 tgacaataga gggggagttt gtactcatgt tggccatctt gccaagccac ctctgcgcag
     1861 acctgatggc agccccacac gcgcgttttg acgatggtgt ggtgcacctg tgctgggtgc
     1921 ggagcggcat ctcacgggcc gcacttctac gaattttgct ggccatggaa catggaaacc
     1981 acttcagcct gggctgccca catctgggct atgctgcagc acgtgccttc cgccttgagc
     2041 cactcacgcc tcgtggggtg ctcactgtag atggggaatt agtagagtat gggccaatac
     2101 aggcacaggt gcatccaagt ctcgccacac tgctcactgg gcctgcaggt caaaagcctc
     2161 gagcctgaat gagcccaaag catgccaagt tgatgggacc agagccccat aggctaaggt
     2221 ctacctttta taggtagaag tggggcctga actcagaact gcaagggtag agagtgctcc
     2281 agaccctcag ttcccagagg accctagagg ctcgagggtg ggatctgcct ttcttgatgt
     2341 ccaatgatgg ggcctggaat gtatgagcta gcaaggcttc ttcagcttac tgtccagtca
     2401 gggtttcttc ttgcctattt cggtgcctct acttgactgg ccaatcagcc cttgaggggc
     2461 aggttccccc aggtggtccc tagatttgca ctaatgttcc cctggccagt taggggtggg
     2521 atgttctgtg tcttgtgtgt ccctgtccct agtctaaaaa gcaattgaaa aggtctatgc
     2581 aataaaggtg ttgctttctc tggacctgca
//
LOCUS       NM_001437805            8911 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 4, mRNA.
ACCESSION   NM_001437805 XM_063288658
VERSION     NM_001437805.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8911)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8911)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8911)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8911)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288658.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000001.1  9465986-9466512     c
            528-686             JAXUCZ010000001.1  9463224-9463382     c
            687-923             JAXUCZ010000001.1  9459457-9459693     c
            924-1470            JAXUCZ010000001.1  9454995-9455541     c
            1471-1673           JAXUCZ010000001.1  9448660-9448862     c
            1674-1830           JAXUCZ010000001.1  9447057-9447213     c
            1831-1886           JAXUCZ010000001.1  9441551-9441606     c
            1887-1948           JAXUCZ010000001.1  9435618-9435679     c
            1949-2086           JAXUCZ010000001.1  9433972-9434109     c
            2087-2163           JAXUCZ010000001.1  9426874-9426950     c
            2164-8911           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8911
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..527
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    521..523
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     exon            528..686
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..2179
                     /gene="Phactr2"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 4"
                     /protein_id="NP_001424734.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MIHIGEEATQEENVGKPEEGNVSVCEKGPPREEQAEEKTENSEI
                     HSETPAALPPTVPSKPKPKPKPKKSSVPPKGGTTSGASHKGDEVPPTRKNVKAPSKQA
                     PVPPPKPTSRNTSREAAGSSHPKKTTGSKASSSPSASSTSSHPRGPKESLTGKAGAVG
                     TTRGKKKISKQPAAAASRLSPNTVTSETSSLKGELSDTGVESLKPEETVAGAEEEATG
                     KPKAVVVALPPVTVPPSSPALPLPPEDPCTIALDTPMVLVSDGPTLPISALETSPLPG
                     TEEPANRTTPYSSTGLGGSREQAKCFTTKDGPGKAGPQLLTPGQMGDSLESFSAPEDE
                     APREYQANDSDSDGPILYTDDDDEEDDDDDSTGESALASKIRRRDTLAIKLGNRPSKK
                     ELEDKNILQRTSEEERQELRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAK
                     MELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAA
                     IRKELNEFKSTEMEVHEESRQFTRFHRP"
     misc_feature    1703..1780
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1703..1780
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1820..1894
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1820..1894
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1931..2008
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1931..2008
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            687..923
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1470
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1673
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1830
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1886
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1948
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2086
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2163
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..8911
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagatctcc caggtttcag ccaagagcta gagaaagtag ttttctattt attcatagta
       61 gtcatctttc tcttccacaa aaccattatc ttgagaattc ctatctgaaa gtctgtctcc
      121 tgctgctcac cttgtgacag acagcttctc tccatcgttg aggactctct taaggcctct
      181 gtcttcctga cactgtgcct gacagttatt atcaattatg aactttgttt ggtagaccag
      241 atagactttt taagtccctc cagctgccct ggctgtgatc tcatcccacc ctaagctgta
      301 acagctaact ggctatggtt attataccat tcatgctgtg ttttccacac caagcttgac
      361 ctcaatctga gaattcacca aaatggtctt ctctcctgag aaggtctcac agatggtcta
      421 gtcccccatt tatttcttcc ctccatcttt tcttggagca gttacataag ggcatgtaag
      481 tgtctgacct gcttgcctga gacctgcttt tcacatcttc tagtgtgatg gagatgtaac
      541 agttaacttt gaaaattcaa acgggcacat gatacacatc ggagaggaag ctacccaaga
      601 ggagaatgta gggaaacctg aagaagggaa tgtctctgtg tgtgagaaag gaccacctcg
      661 agaggaacag gcagaagaga agacagagaa ctctgagatc cactctgaaa caccggctgc
      721 tctacctcct accgttcctt ctaaacctaa acccaaaccc aaaccaaaaa agtcttctgt
      781 gcctcccaaa ggaggcacca cgtctggggc cagccacaaa ggggatgaag tacctcctac
      841 tagaaaaaat gtcaaggctc ccagtaagca ggcccccgtc cctccgccca agccaacgag
      901 ccgaaacaca tcccgggagg ctgctggttc ctctcacccg aagaaaacaa ctggttccaa
      961 agcctcatcc tcaccatctg cttcgtccac ctcctctcat cccagaggac ccaaggagtc
     1021 actcactggc aaagcaggcg cggttgggac cacaaggggc aagaaaaaga ttagcaagca
     1081 gccagcagcg gcggcatccc gactgtcccc caacacagtc acttctgaaa cgtctagtct
     1141 taaaggagag ctctcagaca ctggggtaga gagcctcaag ccagaggaaa ctgttgctgg
     1201 agcagaggag gaggccacag gcaaacccaa ggcggtcgtc gtcgctctgc cacctgtcac
     1261 agtaccgcca tcttcacctg cccttcctct gccccctgag gatccatgca ctattgcctt
     1321 ggacactccc atggtcctag tcagtgatgg acccaccctg cccatctctg ccttagaaac
     1381 aagtccgctc cctgggactg aagaaccagc gaacagaacc actccgtact caagcaccgg
     1441 cttaggtggg agccgagagc aggcaaaatg ttttacaacc aaagatgggc cgggaaaggc
     1501 tggacctcaa ttgctgaccc ctggacagat gggagactca ttagaatcct tcagtgcccc
     1561 agaggatgag gccccaagag agtaccaagc caatgactct gactcggatg gacccatctt
     1621 atacacagat gatgatgatg aagaagatga tgatgatgac agcactggag aaagtgcatt
     1681 ggcaagtaag atcagacgaa gggatacact cgccatcaaa cttggcaaca gaccatccaa
     1741 gaaagagcta gaggacaaaa acatcctgca gcgaacgtct gaagaagaaa ggcaggagct
     1801 gcgacaacag atcggaacca agctggtcag gagactcagc cagaggccaa ccactgaaga
     1861 attagagcag agaaacatct taaaacaaaa gaatgaagaa gaggagcagg aagcaaaaat
     1921 ggaactcaaa cggaggctca gccggaagct cagcctaaga cctactgtgg cagagctaca
     1981 agcccgaaga atcctgcggt ttaatgagta tgtggaagtc acagattccc cggactacga
     2041 cagacgtgcg gacaagccct gggccaggtt gacacctgcg gacaaggcag caataaggaa
     2101 agaactaaat gaatttaaaa gcacggaaat ggaagttcac gaagagagtc gacagtttac
     2161 aaggtttcac cgtccataat gaagcatggg acagcttgga aataaggacc ctgacattgc
     2221 actgagattt gaatgtgtgt gtttccgttt cgttgtggtg aaggaggtgt acgactcggc
     2281 tttggttgaa gacgctcctc accctgacag cccagacgag ggcaacaagc tgagaggcgg
     2341 atgcggcaag cctggctgcc cacggtgtgc actgatataa ggggcactct gactctctca
     2401 gctatgtttc agcgggaatt ttaatcaaag aagacaagca gaagacaatc gccagtttgg
     2461 ctaccagaaa gccatacggt atagcacgtg tgggttcaca aacaatagac attggaattg
     2521 ctggtggcca ccccaacagg gtgggagctg aaactgagaa agagagagaa ccgtttcatt
     2581 atgttaatga agagaagaag agtgaagaga agtatatttt tgaagtaggc gttcggtagc
     2641 tgaggacttc ctaagggatt tgggaaccta ctcaaccaac gtagattcct taaagacttc
     2701 attctagaac attcttgttt caccaataat ggttctgtgt agtagcctct tttttttttt
     2761 tttttaatgt tgtgccagtg aacccagttg ccagaaacaa atatgagtgt tcattcaatg
     2821 caaggagctc ctaccagctc tcaccaagca tgcttgctct tgctgtgttg catgcctttc
     2881 agtagtacag ccaagcccac actttcttat attgcttccc taacgtatga gcgctctaca
     2941 agggtaacag gaatgaggtc agatgcaatg tgaccctgta aaactgtggc aagcttcaga
     3001 aataaatctt ctgctctttc cctgtcttga ttctctccaa agtcaggaaa ccatccttta
     3061 gctaaagaag atgacccgga cagtcatggt accctttaaa cactcaatcc agagttgtca
     3121 cttaagcaac atacaagtgt ctgctgcctg ctccaagtcc tgagagggga tttaaagaac
     3181 ataccagata gtttaaaatc ctgcattaat ttttttttaa tattaggttg ctgctatttt
     3241 ttttaaaaaa aagtgaaaca gtaaaaacca agcatatgaa tttaacaaaa atatcctgag
     3301 gcttaaagga acacagaaga cgacttctgg tttatgtaaa ggaaacctta ccttctctga
     3361 tgaatttgtg gatcatatcc atatacccgg tatttactcc ccatgccaga gaagcagtaa
     3421 gatccccggg ccagcttccc caggagtctg taatcagtct tgtttacatt aaaaagcttc
     3481 ccccctcaaa ttgttctctt cagtgtccgg ccccagcaca gaaccccaga agggcttact
     3541 tgtgatacta ccttgaattt cgttgtccct taacaattgt tttaagcccc ttggattaaa
     3601 agaagaagaa aaagaaggca gaatctatat catgcttttt ttttccttaa gaaggcagaa
     3661 tctataccag gtctatctca ttctttgatc tggagctatg ccgattctga agcctgtaat
     3721 tttctatttc gagtgaacag tcagcctcga atcagtcaag taagtgtagg ccctgccatt
     3781 ctgtggtatc tggagggacc gcttgaaatt tgatgatttc atttaaaagt gaacgtggtt
     3841 agcggcagcg gactgttgtg aaagcccaga ggaaccgcgc cacgaggtaa ccagcgttca
     3901 tgcacccacc gccgtgctta gccgtttgcg gtaataagac aaggctgctg cctacactag
     3961 ttcgtctggc taacagcatg aggcagactt tgcttttgaa atagtgtctg tgcgtgcact
     4021 agtgtttgtc tttgtctttg ggggcttgct cgttctattg ttgttttgca gtgccgggac
     4081 tgaaccaggc ccttgcgcat gctctgtgta ctctaacccc tgagccaaca cccctaacct
     4141 tcgtttgaca agagtctcaa ctcaaccgtg aatagtaatt ttgttctcat tacttataga
     4201 gtagttttcc ctcgtgatat cctactatcg tcttagtgtc gtgggaaaaa gtgacaagac
     4261 aggtgatgtt ccttcgtcta tgcttataat ctcgaaacgt tttaaaaacc ttctaatgaa
     4321 atgtcctcaa aatgttgtaa attcaagaca ggagcaacac ggcttgccat tcaaagtgtg
     4381 tttcatagaa agtttctgtc tggttggtca aaagaacctt ttttccccac tagtggtgca
     4441 ggtgacacag gttttaatct tccacagtta atgttcaaaa tgccacgcat cgttgaagct
     4501 cccagttcag cccccagtac tgcacaaacg aaaatctgtc tcctgataac atctgccaga
     4561 ttggtgttac ctacaccttt tcttcatact aactgataca tttcaagaag cttttgtgag
     4621 aaagtttaga aagctaaaaa attaactact aacggtctaa tatttaagta acctgggacc
     4681 actgatgact tcattatgat ggcctagtac ctgttttaaa agccgtggga agaattaaaa
     4741 tatcacgagc caagctgtac ttctcagaat aaggctctac tttgctgggt aatttgtaaa
     4801 ggcagaaacg tttaaaggct acatagcctt agcagcagct cactcacagg tctccatcca
     4861 ggcatcccca cagaaggcaa agctccctct ccctgtaatt accgctctgc ccactgccag
     4921 catttctgca gtccaaccaa caagcagcta ctctttaaga aaataaatgt gtgcagaaac
     4981 cagggcgtgc gtgcgtgcgt gcgtgtgtgt gtgtgtgtgc atgtgtgtgt tgccattgta
     5041 acacaattcc agtttttcac taaagcatac cattaggcaa tggagtgagc gttcctgact
     5101 ccggagttat actaaggaaa agaaaattag cccacctcac tggaggcccc aacaagaaaa
     5161 gaaactggac cagacagaaa agccaaagtg gccattcgga gggagaccct gttggtatta
     5221 cggtattgag aagacactaa gctcccttca cgcagcagcc tcgtggtcat caccaaccaa
     5281 ccaacgtgac gaatgcagtc ctaatccgtg ttcgccaggg gcaccttggc tggtcatttc
     5341 ctgtaggtat gaaatgtctg gtggttttgt gtgagctata atttaccttt atgtttattc
     5401 cttaagttgt tttaacccga agtctgcaat atccagagaa ccatctcggg tatttgagca
     5461 cctattaaag gaaaggcaag catatccatc tctctgcctt cccagtgaag aagctgactt
     5521 tctggtttct ttcttcttgc ccttatcaac ccaatgaacg cagttctctg tctccgatgt
     5581 cgggagaaag ttctggaact taattgcaaa tatatttaag gaaagagaag aatctaataa
     5641 gcctttcaaa aaccaccaag tatggaaatg agtcgtgagt cctgagaaaa ggtcaggcag
     5701 gctttgtatc ctgtaattaa cccagcgatc cattggcgct tttttaaaaa tacaggagtt
     5761 tgtactcgag ggagaacatg ggttcatctc acatgtccag atacgtgcaa ccccacagca
     5821 acacatgccg gacacccgtg accgttaggc tgtaggcaca ctagaaagag gccggtctgc
     5881 catgtagcag cggtctgtct gcatttgaac agtaaaaaat agtttcctct tctccatgtc
     5941 ttgttctaaa acatccatcc tgtgttgctt gggcttggcc ctagccgcgt attttagaga
     6001 catcaacatt ccttagtgta tgtgaaacgg gcttaatcta acacaggatg tatggattta
     6061 tgtccttttc ctcctcggca cggcggattt gtttatgcat tcctaaatcc ccacttcact
     6121 tacttatcgt tacaagtacg gggagctcta ctggggaggt catttttcct tcagggctgt
     6181 acaggacaca gattgtccct tcacccctta aaatgattaa tcctttgtta gtattcgctg
     6241 tctattgact ggctgatatg tttttattta acaaaagcag aacgaacctt taggagatat
     6301 gtgctagagg ggccaacggg gacaaaaaat aagcaattgt caaattaatg agaacagctt
     6361 cctgaaagaa accatattct caggcaactc aaagtcgagc tccacagagg gactctaggt
     6421 ctccctacag aggcactcgg ggaccaaagg gtgatggaga tggaggtgac cattctcgtt
     6481 tttgcttcct gtttcccttt tctaatcgtt aagtctaaaa cctcttttga agcttgaacc
     6541 actgttggca tttctagaaa gcaactgtaa taggggctag tgcttttctt tctttctttc
     6601 tttctttctt tctttctttc tttctttctt tttttagtat gactgtattt tgttttgttt
     6661 gtttgttgag gccagcttca ccccataatt ttttttaaaa aaatttcatt ttttacattt
     6721 aaaaaaaatg caagtttttt tttcccaaag aaatggagag tcctgtggct gctatcccgg
     6781 cctaatgcca gtttttaacc atgttgggtt gtgctgcagg gaaatgccag ttagcctgtt
     6841 gcttctttaa cacagctgcc tgtgaacaaa gaagcgctga tagatgtctc ccggtggggg
     6901 tgctgttggt atttggatct gggtaaatcc ttgctgtgct gaaatgtacc acatgttgca
     6961 agatgttcag tatcctgggc tcctggtgac tcaacaccag acattgtgag aaccggaaaa
     7021 aaagaaaaga aaagaaaaga aaagaaaaga aaagaaaaga aaagaaaaga gaagaaaaaa
     7081 gcttcccgtt tgcctgcata gaaggataaa cccctcacct gagtgccact gtctcctgca
     7141 acaagggtac atgggggaac ctgcctgtct ctaaatacca tgtctactgc cttgcacgtc
     7201 tctacccact tctctttcaa agccttctgc ttagatgcag cttaaactgg cctgttccct
     7261 agaaaagagc ttcctaggta gtcttgtcca ttacggtggg cagcgtgaca tggcctgata
     7321 tttctggagg gtacacgaag caagtcttgt tcattacttc tgtgttactt cagaactaga
     7381 ctcctggttg ccagaacaca gtgtctctga gtaaaacact ggtctttgga actcagcatt
     7441 ggattctacc tggtcatact gaagaccgag ttgcaaaaag agtctccctt cctcctgttg
     7501 acaacggagt taatccacac aaaaagacac ggggactccc tcgtgtaaac atccacacgg
     7561 ttccgctttc ctaataagac gtgcaaatat gacatgttgg caggaacgta ggtaaactgg
     7621 attgcattca tgctgttcac accacagacg ggcaaaacga aatgagtttt cccccaggtg
     7681 tagctcgatc aagctgtgct aaccgtacag aaagacgctc tttacgccac tgaaattaaa
     7741 tagtcagtgg gtcttgaaaa atatttagat gaattgcagc tagctgcaag gatggaatta
     7801 attcctccca ttcttcacat taaaattctg aagactcccc gcccctcccc cttcttttaa
     7861 gcatagcaac ttggagtcag taaaggtggc catagcgtaa acctatagat ggtgctttaa
     7921 aacaaaatcg tatctttctt aatagcagta ttttttaaag cagagaatag actgaaagaa
     7981 gtaaatgcgg cagaacgctg ttccacactc aggtaaattt tgtggtttat taaaatgcca
     8041 ataatatttg tgcacttgcc agcgtcaggg gcttttccct taatggatgc tctcggtgtg
     8101 atttttttcc tcttctttaa ctgtatcgtt acattgttta gagagcatcc accaccagga
     8161 tttgccaccg tagtgataac tagcattagg aaagaattac cgagaactga gggtcaaacc
     8221 actttcatca cctaaacgac aggcactagt tctttagtat ttcttcagtg gcttgggtgt
     8281 gcccatgtat tcaaagcatt ccgcacgaat tttaccagtt aaataccggc tgaaaagtca
     8341 gaccagtctc tctccgcacc tcctctctct gtaacaatgt ttcgtttttg ttttgttttt
     8401 ttcccataat gagctgtctg tgttcttttg ttatttcaaa ctttggttca agtggtagca
     8461 atggtacaca ctgtgatggt ggggagacta gctgggtgag tctctagtgt gtgatctaat
     8521 ctttacatgg gtgtgctatc tgtgggtgtt gataactgga actgtacccg gacaacacga
     8581 cagtttctct ctcttcctgt tcctgattca ctactatatc atagtacgtg ggtatgaccc
     8641 ctgcgagtat ccacaccgaa gcctatgtat tccacaattg taacctgaaa gaccatgcat
     8701 tatctttttt taattcatac tggtgtttgt gttatttaaa gtggaaaatt ataccctatc
     8761 tagtagtata atgtaatata ataggatact ccgctgtgca cagttccaag tgccttagaa
     8821 cattgtttag ctttcctaag tatacgtaaa tgcatatatg tgtgtataaa attgggaaat
     8881 gttacctcaa taaagtcatt gggaaatcct a
//
LOCUS       NM_001437806            8463 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 5, mRNA.
ACCESSION   NM_001437806 XM_063288660
VERSION     NM_001437806.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8463)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8463)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8463)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8463)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288660.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.862588.1,
                                           SRR26360186.2486458.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  9530860-9531085     c
            227-394             JAXUCZ010000001.1  9497140-9497307     c
            395-475             JAXUCZ010000001.1  9468266-9468346     c
            476-1022            JAXUCZ010000001.1  9454995-9455541     c
            1023-1225           JAXUCZ010000001.1  9448660-9448862     c
            1226-1382           JAXUCZ010000001.1  9447057-9447213     c
            1383-1438           JAXUCZ010000001.1  9441551-9441606     c
            1439-1500           JAXUCZ010000001.1  9435618-9435679     c
            1501-1638           JAXUCZ010000001.1  9433972-9434109     c
            1639-1715           JAXUCZ010000001.1  9426874-9426950     c
            1716-8463           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8463
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..226
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    148..150
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     CDS             181..1731
                     /gene="Phactr2"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 5"
                     /protein_id="NP_001424735.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MGQTSVSALSPQPGSVDGLDKASIANSDGPPAGSQTPPFKRKGK
                     LSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQAGSS
                     HPKKTTGSKASSSPSASSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLS
                     PNTVTSETSSLKGELSDTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPA
                     LPLPPEDPCTIALDTPMVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSR
                     EQAKCFTTKDGPGKAGPQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTD
                     DDDEEDDDDDSTGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELR
                     QQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAEL
                     QARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESR
                     QFTRFHRP"
     misc_feature    397..462
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    397..462
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    1255..1332
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1255..1332
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1372..1446
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1372..1446
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1483..1560
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1483..1560
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            227..394
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..475
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1022
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1225
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1382
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1438
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1500
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1638
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1715
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..8463
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccgctggg ccggcttggc cgctgccagg gccgggcgac ccgcgcgcgc ggggagaagg
       61 tgcggggact ggcgggcgcg ggccgagatg agcgcgcggg aggccggcgg cgagcggacg
      121 ggcgcgcgca ggagcggagc agcccggtga ggcggaggcg cggcggggcg gtcacccgcc
      181 atgggccaga cctcggtgtc cgcgctgtcc ccgcagcccg gcagcgttga tggactagac
      241 aaagcctcca tagcaaactc agatggcccc ccagcaggtt cccagacacc tcccttcaag
      301 agaaagggga aactctccac cattggtaaa atcttcaagc cttggaaatg gaggaaaaag
      361 aagaccagtg acaagtttag agagacctca gcagtattag agaggaagat atccaccaga
      421 caaagtagag aggagctgat aagaaggggc ctgcttaagg aattgcctga tcaagctggt
      481 tcctctcacc cgaagaaaac aactggttcc aaagcctcat cctcaccatc tgcttcgtcc
      541 acctcctctc atcccagagg acccaaggag tcactcactg gcaaagcagg cgcggttggg
      601 accacaaggg gcaagaaaaa gattagcaag cagccagcag cggcggcatc ccgactgtcc
      661 cccaacacag tcacttctga aacgtctagt cttaaaggag agctctcaga cactggggta
      721 gagagcctca agccagagga aactgttgct ggagcagagg aggaggccac aggcaaaccc
      781 aaggcggtcg tcgtcgctct gccacctgtc acagtaccgc catcttcacc tgcccttcct
      841 ctgccccctg aggatccatg cactattgcc ttggacactc ccatggtcct agtcagtgat
      901 ggacccaccc tgcccatctc tgccttagaa acaagtccgc tccctgggac tgaagaacca
      961 gcgaacagaa ccactccgta ctcaagcacc ggcttaggtg ggagccgaga gcaggcaaaa
     1021 tgttttacaa ccaaagatgg gccgggaaag gctggacctc aattgctgac ccctggacag
     1081 atgggagact cattagaatc cttcagtgcc ccagaggatg aggccccaag agagtaccaa
     1141 gccaatgact ctgactcgga tggacccatc ttatacacag atgatgatga tgaagaagat
     1201 gatgatgatg acagcactgg agaaagtgca ttggcaagta agatcagacg aagggataca
     1261 ctcgccatca aacttggcaa cagaccatcc aagaaagagc tagaggacaa aaacatcctg
     1321 cagcgaacgt ctgaagaaga aaggcaggag ctgcgacaac agatcggaac caagctggtc
     1381 aggagactca gccagaggcc aaccactgaa gaattagagc agagaaacat cttaaaacaa
     1441 aagaatgaag aagaggagca ggaagcaaaa atggaactca aacggaggct cagccggaag
     1501 ctcagcctaa gacctactgt ggcagagcta caagcccgaa gaatcctgcg gtttaatgag
     1561 tatgtggaag tcacagattc cccggactac gacagacgtg cggacaagcc ctgggccagg
     1621 ttgacacctg cggacaaggc agcaataagg aaagaactaa atgaatttaa aagcacggaa
     1681 atggaagttc acgaagagag tcgacagttt acaaggtttc accgtccata atgaagcatg
     1741 ggacagcttg gaaataagga ccctgacatt gcactgagat ttgaatgtgt gtgtttccgt
     1801 ttcgttgtgg tgaaggaggt gtacgactcg gctttggttg aagacgctcc tcaccctgac
     1861 agcccagacg agggcaacaa gctgagaggc ggatgcggca agcctggctg cccacggtgt
     1921 gcactgatat aaggggcact ctgactctct cagctatgtt tcagcgggaa ttttaatcaa
     1981 agaagacaag cagaagacaa tcgccagttt ggctaccaga aagccatacg gtatagcacg
     2041 tgtgggttca caaacaatag acattggaat tgctggtggc caccccaaca gggtgggagc
     2101 tgaaactgag aaagagagag aaccgtttca ttatgttaat gaagagaaga agagtgaaga
     2161 gaagtatatt tttgaagtag gcgttcggta gctgaggact tcctaaggga tttgggaacc
     2221 tactcaacca acgtagattc cttaaagact tcattctaga acattcttgt ttcaccaata
     2281 atggttctgt gtagtagcct cttttttttt tttttttaat gttgtgccag tgaacccagt
     2341 tgccagaaac aaatatgagt gttcattcaa tgcaaggagc tcctaccagc tctcaccaag
     2401 catgcttgct cttgctgtgt tgcatgcctt tcagtagtac agccaagccc acactttctt
     2461 atattgcttc cctaacgtat gagcgctcta caagggtaac aggaatgagg tcagatgcaa
     2521 tgtgaccctg taaaactgtg gcaagcttca gaaataaatc ttctgctctt tccctgtctt
     2581 gattctctcc aaagtcagga aaccatcctt tagctaaaga agatgacccg gacagtcatg
     2641 gtacccttta aacactcaat ccagagttgt cacttaagca acatacaagt gtctgctgcc
     2701 tgctccaagt cctgagaggg gatttaaaga acataccaga tagtttaaaa tcctgcatta
     2761 attttttttt aatattaggt tgctgctatt ttttttaaaa aaaagtgaaa cagtaaaaac
     2821 caagcatatg aatttaacaa aaatatcctg aggcttaaag gaacacagaa gacgacttct
     2881 ggtttatgta aaggaaacct taccttctct gatgaatttg tggatcatat ccatataccc
     2941 ggtatttact ccccatgcca gagaagcagt aagatccccg ggccagcttc cccaggagtc
     3001 tgtaatcagt cttgtttaca ttaaaaagct tcccccctca aattgttctc ttcagtgtcc
     3061 ggccccagca cagaacccca gaagggctta cttgtgatac taccttgaat ttcgttgtcc
     3121 cttaacaatt gttttaagcc ccttggatta aaagaagaag aaaaagaagg cagaatctat
     3181 atcatgcttt ttttttcctt aagaaggcag aatctatacc aggtctatct cattctttga
     3241 tctggagcta tgccgattct gaagcctgta attttctatt tcgagtgaac agtcagcctc
     3301 gaatcagtca agtaagtgta ggccctgcca ttctgtggta tctggaggga ccgcttgaaa
     3361 tttgatgatt tcatttaaaa gtgaacgtgg ttagcggcag cggactgttg tgaaagccca
     3421 gaggaaccgc gccacgaggt aaccagcgtt catgcaccca ccgccgtgct tagccgtttg
     3481 cggtaataag acaaggctgc tgcctacact agttcgtctg gctaacagca tgaggcagac
     3541 tttgcttttg aaatagtgtc tgtgcgtgca ctagtgtttg tctttgtctt tgggggcttg
     3601 ctcgttctat tgttgttttg cagtgccggg actgaaccag gcccttgcgc atgctctgtg
     3661 tactctaacc cctgagccaa cacccctaac cttcgtttga caagagtctc aactcaaccg
     3721 tgaatagtaa ttttgttctc attacttata gagtagtttt ccctcgtgat atcctactat
     3781 cgtcttagtg tcgtgggaaa aagtgacaag acaggtgatg ttccttcgtc tatgcttata
     3841 atctcgaaac gttttaaaaa ccttctaatg aaatgtcctc aaaatgttgt aaattcaaga
     3901 caggagcaac acggcttgcc attcaaagtg tgtttcatag aaagtttctg tctggttggt
     3961 caaaagaacc ttttttcccc actagtggtg caggtgacac aggttttaat cttccacagt
     4021 taatgttcaa aatgccacgc atcgttgaag ctcccagttc agcccccagt actgcacaaa
     4081 cgaaaatctg tctcctgata acatctgcca gattggtgtt acctacacct tttcttcata
     4141 ctaactgata catttcaaga agcttttgtg agaaagttta gaaagctaaa aaattaacta
     4201 ctaacggtct aatatttaag taacctggga ccactgatga cttcattatg atggcctagt
     4261 acctgtttta aaagccgtgg gaagaattaa aatatcacga gccaagctgt acttctcaga
     4321 ataaggctct actttgctgg gtaatttgta aaggcagaaa cgtttaaagg ctacatagcc
     4381 ttagcagcag ctcactcaca ggtctccatc caggcatccc cacagaaggc aaagctccct
     4441 ctccctgtaa ttaccgctct gcccactgcc agcatttctg cagtccaacc aacaagcagc
     4501 tactctttaa gaaaataaat gtgtgcagaa accagggcgt gcgtgcgtgc gtgcgtgtgt
     4561 gtgtgtgtgt gcatgtgtgt gttgccattg taacacaatt ccagtttttc actaaagcat
     4621 accattaggc aatggagtga gcgttcctga ctccggagtt atactaagga aaagaaaatt
     4681 agcccacctc actggaggcc ccaacaagaa aagaaactgg accagacaga aaagccaaag
     4741 tggccattcg gagggagacc ctgttggtat tacggtattg agaagacact aagctccctt
     4801 cacgcagcag cctcgtggtc atcaccaacc aaccaacgtg acgaatgcag tcctaatccg
     4861 tgttcgccag gggcaccttg gctggtcatt tcctgtaggt atgaaatgtc tggtggtttt
     4921 gtgtgagcta taatttacct ttatgtttat tccttaagtt gttttaaccc gaagtctgca
     4981 atatccagag aaccatctcg ggtatttgag cacctattaa aggaaaggca agcatatcca
     5041 tctctctgcc ttcccagtga agaagctgac tttctggttt ctttcttctt gcccttatca
     5101 acccaatgaa cgcagttctc tgtctccgat gtcgggagaa agttctggaa cttaattgca
     5161 aatatattta aggaaagaga agaatctaat aagcctttca aaaaccacca agtatggaaa
     5221 tgagtcgtga gtcctgagaa aaggtcaggc aggctttgta tcctgtaatt aacccagcga
     5281 tccattggcg cttttttaaa aatacaggag tttgtactcg agggagaaca tgggttcatc
     5341 tcacatgtcc agatacgtgc aaccccacag caacacatgc cggacacccg tgaccgttag
     5401 gctgtaggca cactagaaag aggccggtct gccatgtagc agcggtctgt ctgcatttga
     5461 acagtaaaaa atagtttcct cttctccatg tcttgttcta aaacatccat cctgtgttgc
     5521 ttgggcttgg ccctagccgc gtattttaga gacatcaaca ttccttagtg tatgtgaaac
     5581 gggcttaatc taacacagga tgtatggatt tatgtccttt tcctcctcgg cacggcggat
     5641 ttgtttatgc attcctaaat ccccacttca cttacttatc gttacaagta cggggagctc
     5701 tactggggag gtcatttttc cttcagggct gtacaggaca cagattgtcc cttcacccct
     5761 taaaatgatt aatcctttgt tagtattcgc tgtctattga ctggctgata tgtttttatt
     5821 taacaaaagc agaacgaacc tttaggagat atgtgctaga ggggccaacg gggacaaaaa
     5881 ataagcaatt gtcaaattaa tgagaacagc ttcctgaaag aaaccatatt ctcaggcaac
     5941 tcaaagtcga gctccacaga gggactctag gtctccctac agaggcactc ggggaccaaa
     6001 gggtgatgga gatggaggtg accattctcg tttttgcttc ctgtttccct tttctaatcg
     6061 ttaagtctaa aacctctttt gaagcttgaa ccactgttgg catttctaga aagcaactgt
     6121 aataggggct agtgcttttc tttctttctt tctttctttc tttctttctt tctttctttc
     6181 tttttttagt atgactgtat tttgttttgt ttgtttgttg aggccagctt caccccataa
     6241 ttttttttaa aaaaatttca ttttttacat ttaaaaaaaa tgcaagtttt tttttcccaa
     6301 agaaatggag agtcctgtgg ctgctatccc ggcctaatgc cagtttttaa ccatgttggg
     6361 ttgtgctgca gggaaatgcc agttagcctg ttgcttcttt aacacagctg cctgtgaaca
     6421 aagaagcgct gatagatgtc tcccggtggg ggtgctgttg gtatttggat ctgggtaaat
     6481 ccttgctgtg ctgaaatgta ccacatgttg caagatgttc agtatcctgg gctcctggtg
     6541 actcaacacc agacattgtg agaaccggaa aaaaagaaaa gaaaagaaaa gaaaagaaaa
     6601 gaaaagaaaa gaaaagaaaa gagaagaaaa aagcttcccg tttgcctgca tagaaggata
     6661 aacccctcac ctgagtgcca ctgtctcctg caacaagggt acatggggga acctgcctgt
     6721 ctctaaatac catgtctact gccttgcacg tctctaccca cttctctttc aaagccttct
     6781 gcttagatgc agcttaaact ggcctgttcc ctagaaaaga gcttcctagg tagtcttgtc
     6841 cattacggtg ggcagcgtga catggcctga tatttctgga gggtacacga agcaagtctt
     6901 gttcattact tctgtgttac ttcagaacta gactcctggt tgccagaaca cagtgtctct
     6961 gagtaaaaca ctggtctttg gaactcagca ttggattcta cctggtcata ctgaagaccg
     7021 agttgcaaaa agagtctccc ttcctcctgt tgacaacgga gttaatccac acaaaaagac
     7081 acggggactc cctcgtgtaa acatccacac ggttccgctt tcctaataag acgtgcaaat
     7141 atgacatgtt ggcaggaacg taggtaaact ggattgcatt catgctgttc acaccacaga
     7201 cgggcaaaac gaaatgagtt ttcccccagg tgtagctcga tcaagctgtg ctaaccgtac
     7261 agaaagacgc tctttacgcc actgaaatta aatagtcagt gggtcttgaa aaatatttag
     7321 atgaattgca gctagctgca aggatggaat taattcctcc cattcttcac attaaaattc
     7381 tgaagactcc ccgcccctcc cccttctttt aagcatagca acttggagtc agtaaaggtg
     7441 gccatagcgt aaacctatag atggtgcttt aaaacaaaat cgtatctttc ttaatagcag
     7501 tattttttaa agcagagaat agactgaaag aagtaaatgc ggcagaacgc tgttccacac
     7561 tcaggtaaat tttgtggttt attaaaatgc caataatatt tgtgcacttg ccagcgtcag
     7621 gggcttttcc cttaatggat gctctcggtg tgattttttt cctcttcttt aactgtatcg
     7681 ttacattgtt tagagagcat ccaccaccag gatttgccac cgtagtgata actagcatta
     7741 ggaaagaatt accgagaact gagggtcaaa ccactttcat cacctaaacg acaggcacta
     7801 gttctttagt atttcttcag tggcttgggt gtgcccatgt attcaaagca ttccgcacga
     7861 attttaccag ttaaataccg gctgaaaagt cagaccagtc tctctccgca cctcctctct
     7921 ctgtaacaat gtttcgtttt tgttttgttt ttttcccata atgagctgtc tgtgttcttt
     7981 tgttatttca aactttggtt caagtggtag caatggtaca cactgtgatg gtggggagac
     8041 tagctgggtg agtctctagt gtgtgatcta atctttacat gggtgtgcta tctgtgggtg
     8101 ttgataactg gaactgtacc cggacaacac gacagtttct ctctcttcct gttcctgatt
     8161 cactactata tcatagtacg tgggtatgac ccctgcgagt atccacaccg aagcctatgt
     8221 attccacaat tgtaacctga aagaccatgc attatctttt tttaattcat actggtgttt
     8281 gtgttattta aagtggaaaa ttatacccta tctagtagta taatgtaata taataggata
     8341 ctccgctgtg cacagttcca agtgccttag aacattgttt agctttccta agtatacgta
     8401 aatgcatata tgtgtgtata aaattgggaa atgttacctc aataaagtca ttgggaaatc
     8461 cta
//
LOCUS       NM_001437840            4062 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 9, mRNA.
ACCESSION   NM_001437840 XM_063281283
VERSION     NM_001437840.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4062)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4062)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4062)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4062)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4062)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4062)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4062)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4062)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4062)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063281283.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2312438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217877711-217877783
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1509           JAXUCZ010000002.1  217916935-217916983
            1510-1585           JAXUCZ010000002.1  217946550-217946625
            1586-1680           JAXUCZ010000002.1  217955065-217955159
            1681-1909           JAXUCZ010000002.1  217957098-217957326
            1910-4062           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4062
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1913
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 9 is encoded by transcript variant 9;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 9"
                     /protein_id="NP_001424769.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKI
                     CDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIA
                     YIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIN"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1509
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1585
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1680
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1909
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..4062
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgcattcag cagatcctgg
      781 aggctgtgct acactgccat cagatgggcg tagtccatcg ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagtcaactg agagctcaaa taccaccatt gaggatgaag
     1501 acgtgaaagc acgaaagcaa gagatcatca aagtcactga gcagctgatt gaagctatca
     1561 acaatgggga cttcgaggct tacacgaaaa tctgtgatcc aggcctcact gcctttgaac
     1621 ccgaagcatt gggcaactta gtggaaggga tggactttca cagattctac tttgaaaatg
     1681 ctttgcccaa aatcaataaa ccaatccaca ctatcatcct gaaccctcac gtacacctgg
     1741 taggggatga tgcagcctgc atagcataca ttcggctcac acagtacatg gatggaaatg
     1801 gaatgccaaa gacaatgcag tcagaagaga ctcgagtgtg gcaccgccgt gatgggaagt
     1861 ggcagaatat tcactttcat cgttcggggt ccccaacagt ccccatcaac taattgtcaa
     1921 cagtgccacg tcttcattct gtcctcaagg cacctggcgg ggtgatcctg ggacatcctc
     1981 tcctcttcat gcatgtttct gagtgcatga agttgtgaag gttctacgtg taatgcatat
     2041 gtgacacgtc atcttaccat gtgacacgcc atcttaccat gtattccttc ctgtacattg
     2101 tttacactcc agctactgga cggatgttcc atgcaaacgt cagttactgc tggcaaacta
     2161 aagagggagc tccgacaaga aaactccgca atactccaag ttcagctgat ccatcaggtt
     2221 tctctgtgga tgccaagatt caaaagactt cataaaatta ctgttcaatg aatgacagtg
     2281 tgtaagagga aaggaaatct ttcaagaatg ctgccattaa tctatttggg cttctcattg
     2341 ggattttggg gttgattttt ttttcatttt ttaaggcaaa tatatatata tatatatata
     2401 tatatatata tatatatata tatatatata tgccttcagt tcctggtaga aatgaatgga
     2461 tgccttttct ctgaaagtgt tggtgttgga taaatggatg gctatgtgag ccaagtcctg
     2521 ggtgattgta ggagcaagaa tcgtttgctg ttctaccatc aaagccatgt tgatttgggt
     2581 cgagctctgt atactggaaa aattcacatc attttctagt ttgattgctt tcagataggc
     2641 acagttctgg tgaatgcttg gcactgatct tggtttttct ttcctaaatc tgtgttctgt
     2701 tttcattata tactatttgc tcctttcctt tgtatttgtt ttcttttccc actcttttct
     2761 ttatctttct ctctcccact ttctttcttt tttatgtttt cctttctata gctgatagtg
     2821 tgtaaaaaca gtaacatttg catatgaagt taaaataaaa atcaaggtct tctagaagct
     2881 aaaactagca cttccggtct ctcacggggc tgtggagttg ttagaagatt taaataaata
     2941 cttaaataag agaggaatga attcagctta ggttaccact tgtgcatagg tatccttgct
     3001 ctgttgaaag tgttggaatt gttgagactt aagctaacag cagtaagagc ctgcttacac
     3061 agtcctggtt ctccccaact agatattgaa gaccaagtgg agcctgacca gggttgcatg
     3121 cagagcactt gttttggacc ttccagacta ggaggcattt actgcctcac tttcactagc
     3181 tagccacagg aagagtgttc tccatcctcc tagaggttga acttgacctt cgtgactagt
     3241 gcagttctag cttctctctt gagtcacagt agcatcctga tgccaggagt taggcttttg
     3301 tccagattaa aacaacgagg aaaaggaaat gccccagttt tctttccgtt tcccatttct
     3361 tctttgtcga ttcggtccct gggagactgt ttctccgcgc tgaactgctt tatggtgcat
     3421 ggaatctcca tcagcgtact tctaccctag ccactcacac tccttagaag ctgattttta
     3481 aagcagaagc aaggaagcaa aagtaaaaca ctcccttccc ctctttttcc tcatttcacc
     3541 ttttggtgtt gattgctaat cactttagat atattgttgc tagtgaatgt atgatagatg
     3601 ggttgaagct tttctgataa ttagcacatg atttaaaaca atatatattt aaaacaaata
     3661 tatacagtac atgtattgag ccgtgttaac ctgccaatga gatctgtgaa aaacgtaatg
     3721 gcctcacttt tccctttgaa tttcttttac ctttctgtga agcagctctg cgtggcatac
     3781 atgtatttaa aaacacaaat agtggtagaa tgggtttttt ttttacactt ttaacttagc
     3841 atgtggtgtt gaagtattac catagatcca gtttgtcttc tgcactaaga tgtgaggaaa
     3901 tcgtgatttg ttctctccag cacagtggaa ttacaccttc atcatcttct attgttttga
     3961 aaacactgca gtttaccatg ggacactgta tataattctt gccgtaatgg taaatgacaa
     4021 attgatatat ttaagagtta ataaatttgt gatttctgct ga
//
LOCUS       NM_001437808            8674 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 7, mRNA.
ACCESSION   NM_001437808
VERSION     NM_001437808.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8674)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8674)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8674)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8674)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000001.1  9465986-9466512     c
            528-686             JAXUCZ010000001.1  9463224-9463382     c
            687-1233            JAXUCZ010000001.1  9454995-9455541     c
            1234-1436           JAXUCZ010000001.1  9448660-9448862     c
            1437-1593           JAXUCZ010000001.1  9447057-9447213     c
            1594-1649           JAXUCZ010000001.1  9441551-9441606     c
            1650-1711           JAXUCZ010000001.1  9435618-9435679     c
            1712-1849           JAXUCZ010000001.1  9433972-9434109     c
            1850-1926           JAXUCZ010000001.1  9426874-9426950     c
            1927-8674           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8674
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..527
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    521..523
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     exon            528..686
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..1942
                     /gene="Phactr2"
                     /note="isoform 7 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 7"
                     /protein_id="NP_001424737.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MIHIGEEATQEENVGKPEEGNVSVCEKGPPREEQAEEKTAGSSH
                     PKKTTGSKASSSPSASSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLSP
                     NTVTSETSSLKGELSDTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPAL
                     PLPPEDPCTIALDTPMVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSRE
                     QAKCFTTKDGPGKAGPQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTDD
                     DDEEDDDDDSTGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQ
                     QIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQ
                     ARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQ
                     FTRFHRP"
     misc_feature    1466..1543
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1466..1543
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1583..1657
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1583..1657
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1694..1771
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1694..1771
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            687..1233
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1436
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1593
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1649
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1711
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1849
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1926
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..8674
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagatctcc caggtttcag ccaagagcta gagaaagtag ttttctattt attcatagta
       61 gtcatctttc tcttccacaa aaccattatc ttgagaattc ctatctgaaa gtctgtctcc
      121 tgctgctcac cttgtgacag acagcttctc tccatcgttg aggactctct taaggcctct
      181 gtcttcctga cactgtgcct gacagttatt atcaattatg aactttgttt ggtagaccag
      241 atagactttt taagtccctc cagctgccct ggctgtgatc tcatcccacc ctaagctgta
      301 acagctaact ggctatggtt attataccat tcatgctgtg ttttccacac caagcttgac
      361 ctcaatctga gaattcacca aaatggtctt ctctcctgag aaggtctcac agatggtcta
      421 gtcccccatt tatttcttcc ctccatcttt tcttggagca gttacataag ggcatgtaag
      481 tgtctgacct gcttgcctga gacctgcttt tcacatcttc tagtgtgatg gagatgtaac
      541 agttaacttt gaaaattcaa acgggcacat gatacacatc ggagaggaag ctacccaaga
      601 ggagaatgta gggaaacctg aagaagggaa tgtctctgtg tgtgagaaag gaccacctcg
      661 agaggaacag gcagaagaga agacagctgg ttcctctcac ccgaagaaaa caactggttc
      721 caaagcctca tcctcaccat ctgcttcgtc cacctcctct catcccagag gacccaagga
      781 gtcactcact ggcaaagcag gcgcggttgg gaccacaagg ggcaagaaaa agattagcaa
      841 gcagccagca gcggcggcat cccgactgtc ccccaacaca gtcacttctg aaacgtctag
      901 tcttaaagga gagctctcag acactggggt agagagcctc aagccagagg aaactgttgc
      961 tggagcagag gaggaggcca caggcaaacc caaggcggtc gtcgtcgctc tgccacctgt
     1021 cacagtaccg ccatcttcac ctgcccttcc tctgccccct gaggatccat gcactattgc
     1081 cttggacact cccatggtcc tagtcagtga tggacccacc ctgcccatct ctgccttaga
     1141 aacaagtccg ctccctggga ctgaagaacc agcgaacaga accactccgt actcaagcac
     1201 cggcttaggt gggagccgag agcaggcaaa atgttttaca accaaagatg ggccgggaaa
     1261 ggctggacct caattgctga cccctggaca gatgggagac tcattagaat ccttcagtgc
     1321 cccagaggat gaggccccaa gagagtacca agccaatgac tctgactcgg atggacccat
     1381 cttatacaca gatgatgatg atgaagaaga tgatgatgat gacagcactg gagaaagtgc
     1441 attggcaagt aagatcagac gaagggatac actcgccatc aaacttggca acagaccatc
     1501 caagaaagag ctagaggaca aaaacatcct gcagcgaacg tctgaagaag aaaggcagga
     1561 gctgcgacaa cagatcggaa ccaagctggt caggagactc agccagaggc caaccactga
     1621 agaattagag cagagaaaca tcttaaaaca aaagaatgaa gaagaggagc aggaagcaaa
     1681 aatggaactc aaacggaggc tcagccggaa gctcagccta agacctactg tggcagagct
     1741 acaagcccga agaatcctgc ggtttaatga gtatgtggaa gtcacagatt ccccggacta
     1801 cgacagacgt gcggacaagc cctgggccag gttgacacct gcggacaagg cagcaataag
     1861 gaaagaacta aatgaattta aaagcacgga aatggaagtt cacgaagaga gtcgacagtt
     1921 tacaaggttt caccgtccat aatgaagcat gggacagctt ggaaataagg accctgacat
     1981 tgcactgaga tttgaatgtg tgtgtttccg tttcgttgtg gtgaaggagg tgtacgactc
     2041 ggctttggtt gaagacgctc ctcaccctga cagcccagac gagggcaaca agctgagagg
     2101 cggatgcggc aagcctggct gcccacggtg tgcactgata taaggggcac tctgactctc
     2161 tcagctatgt ttcagcggga attttaatca aagaagacaa gcagaagaca atcgccagtt
     2221 tggctaccag aaagccatac ggtatagcac gtgtgggttc acaaacaata gacattggaa
     2281 ttgctggtgg ccaccccaac agggtgggag ctgaaactga gaaagagaga gaaccgtttc
     2341 attatgttaa tgaagagaag aagagtgaag agaagtatat ttttgaagta ggcgttcggt
     2401 agctgaggac ttcctaaggg atttgggaac ctactcaacc aacgtagatt ccttaaagac
     2461 ttcattctag aacattcttg tttcaccaat aatggttctg tgtagtagcc tctttttttt
     2521 ttttttttaa tgttgtgcca gtgaacccag ttgccagaaa caaatatgag tgttcattca
     2581 atgcaaggag ctcctaccag ctctcaccaa gcatgcttgc tcttgctgtg ttgcatgcct
     2641 ttcagtagta cagccaagcc cacactttct tatattgctt ccctaacgta tgagcgctct
     2701 acaagggtaa caggaatgag gtcagatgca atgtgaccct gtaaaactgt ggcaagcttc
     2761 agaaataaat cttctgctct ttccctgtct tgattctctc caaagtcagg aaaccatcct
     2821 ttagctaaag aagatgaccc ggacagtcat ggtacccttt aaacactcaa tccagagttg
     2881 tcacttaagc aacatacaag tgtctgctgc ctgctccaag tcctgagagg ggatttaaag
     2941 aacataccag atagtttaaa atcctgcatt aatttttttt taatattagg ttgctgctat
     3001 tttttttaaa aaaaagtgaa acagtaaaaa ccaagcatat gaatttaaca aaaatatcct
     3061 gaggcttaaa ggaacacaga agacgacttc tggtttatgt aaaggaaacc ttaccttctc
     3121 tgatgaattt gtggatcata tccatatacc cggtatttac tccccatgcc agagaagcag
     3181 taagatcccc gggccagctt ccccaggagt ctgtaatcag tcttgtttac attaaaaagc
     3241 ttcccccctc aaattgttct cttcagtgtc cggccccagc acagaacccc agaagggctt
     3301 acttgtgata ctaccttgaa tttcgttgtc ccttaacaat tgttttaagc cccttggatt
     3361 aaaagaagaa gaaaaagaag gcagaatcta tatcatgctt tttttttcct taagaaggca
     3421 gaatctatac caggtctatc tcattctttg atctggagct atgccgattc tgaagcctgt
     3481 aattttctat ttcgagtgaa cagtcagcct cgaatcagtc aagtaagtgt aggccctgcc
     3541 attctgtggt atctggaggg accgcttgaa atttgatgat ttcatttaaa agtgaacgtg
     3601 gttagcggca gcggactgtt gtgaaagccc agaggaaccg cgccacgagg taaccagcgt
     3661 tcatgcaccc accgccgtgc ttagccgttt gcggtaataa gacaaggctg ctgcctacac
     3721 tagttcgtct ggctaacagc atgaggcaga ctttgctttt gaaatagtgt ctgtgcgtgc
     3781 actagtgttt gtctttgtct ttgggggctt gctcgttcta ttgttgtttt gcagtgccgg
     3841 gactgaacca ggcccttgcg catgctctgt gtactctaac ccctgagcca acacccctaa
     3901 ccttcgtttg acaagagtct caactcaacc gtgaatagta attttgttct cattacttat
     3961 agagtagttt tccctcgtga tatcctacta tcgtcttagt gtcgtgggaa aaagtgacaa
     4021 gacaggtgat gttccttcgt ctatgcttat aatctcgaaa cgttttaaaa accttctaat
     4081 gaaatgtcct caaaatgttg taaattcaag acaggagcaa cacggcttgc cattcaaagt
     4141 gtgtttcata gaaagtttct gtctggttgg tcaaaagaac cttttttccc cactagtggt
     4201 gcaggtgaca caggttttaa tcttccacag ttaatgttca aaatgccacg catcgttgaa
     4261 gctcccagtt cagcccccag tactgcacaa acgaaaatct gtctcctgat aacatctgcc
     4321 agattggtgt tacctacacc ttttcttcat actaactgat acatttcaag aagcttttgt
     4381 gagaaagttt agaaagctaa aaaattaact actaacggtc taatatttaa gtaacctggg
     4441 accactgatg acttcattat gatggcctag tacctgtttt aaaagccgtg ggaagaatta
     4501 aaatatcacg agccaagctg tacttctcag aataaggctc tactttgctg ggtaatttgt
     4561 aaaggcagaa acgtttaaag gctacatagc cttagcagca gctcactcac aggtctccat
     4621 ccaggcatcc ccacagaagg caaagctccc tctccctgta attaccgctc tgcccactgc
     4681 cagcatttct gcagtccaac caacaagcag ctactcttta agaaaataaa tgtgtgcaga
     4741 aaccagggcg tgcgtgcgtg cgtgcgtgtg tgtgtgtgtg tgcatgtgtg tgttgccatt
     4801 gtaacacaat tccagttttt cactaaagca taccattagg caatggagtg agcgttcctg
     4861 actccggagt tatactaagg aaaagaaaat tagcccacct cactggaggc cccaacaaga
     4921 aaagaaactg gaccagacag aaaagccaaa gtggccattc ggagggagac cctgttggta
     4981 ttacggtatt gagaagacac taagctccct tcacgcagca gcctcgtggt catcaccaac
     5041 caaccaacgt gacgaatgca gtcctaatcc gtgttcgcca ggggcacctt ggctggtcat
     5101 ttcctgtagg tatgaaatgt ctggtggttt tgtgtgagct ataatttacc tttatgttta
     5161 ttccttaagt tgttttaacc cgaagtctgc aatatccaga gaaccatctc gggtatttga
     5221 gcacctatta aaggaaaggc aagcatatcc atctctctgc cttcccagtg aagaagctga
     5281 ctttctggtt tctttcttct tgcccttatc aacccaatga acgcagttct ctgtctccga
     5341 tgtcgggaga aagttctgga acttaattgc aaatatattt aaggaaagag aagaatctaa
     5401 taagcctttc aaaaaccacc aagtatggaa atgagtcgtg agtcctgaga aaaggtcagg
     5461 caggctttgt atcctgtaat taacccagcg atccattggc gcttttttaa aaatacagga
     5521 gtttgtactc gagggagaac atgggttcat ctcacatgtc cagatacgtg caaccccaca
     5581 gcaacacatg ccggacaccc gtgaccgtta ggctgtaggc acactagaaa gaggccggtc
     5641 tgccatgtag cagcggtctg tctgcatttg aacagtaaaa aatagtttcc tcttctccat
     5701 gtcttgttct aaaacatcca tcctgtgttg cttgggcttg gccctagccg cgtattttag
     5761 agacatcaac attccttagt gtatgtgaaa cgggcttaat ctaacacagg atgtatggat
     5821 ttatgtcctt ttcctcctcg gcacggcgga tttgtttatg cattcctaaa tccccacttc
     5881 acttacttat cgttacaagt acggggagct ctactgggga ggtcattttt ccttcagggc
     5941 tgtacaggac acagattgtc ccttcacccc ttaaaatgat taatcctttg ttagtattcg
     6001 ctgtctattg actggctgat atgtttttat ttaacaaaag cagaacgaac ctttaggaga
     6061 tatgtgctag aggggccaac ggggacaaaa aataagcaat tgtcaaatta atgagaacag
     6121 cttcctgaaa gaaaccatat tctcaggcaa ctcaaagtcg agctccacag agggactcta
     6181 ggtctcccta cagaggcact cggggaccaa agggtgatgg agatggaggt gaccattctc
     6241 gtttttgctt cctgtttccc ttttctaatc gttaagtcta aaacctcttt tgaagcttga
     6301 accactgttg gcatttctag aaagcaactg taataggggc tagtgctttt ctttctttct
     6361 ttctttcttt ctttctttct ttctttcttt ctttttttag tatgactgta ttttgttttg
     6421 tttgtttgtt gaggccagct tcaccccata atttttttta aaaaaatttc attttttaca
     6481 tttaaaaaaa atgcaagttt ttttttccca aagaaatgga gagtcctgtg gctgctatcc
     6541 cggcctaatg ccagttttta accatgttgg gttgtgctgc agggaaatgc cagttagcct
     6601 gttgcttctt taacacagct gcctgtgaac aaagaagcgc tgatagatgt ctcccggtgg
     6661 gggtgctgtt ggtatttgga tctgggtaaa tccttgctgt gctgaaatgt accacatgtt
     6721 gcaagatgtt cagtatcctg ggctcctggt gactcaacac cagacattgt gagaaccgga
     6781 aaaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa agaaaagaaa agagaagaaa
     6841 aaagcttccc gtttgcctgc atagaaggat aaacccctca cctgagtgcc actgtctcct
     6901 gcaacaaggg tacatggggg aacctgcctg tctctaaata ccatgtctac tgccttgcac
     6961 gtctctaccc acttctcttt caaagccttc tgcttagatg cagcttaaac tggcctgttc
     7021 cctagaaaag agcttcctag gtagtcttgt ccattacggt gggcagcgtg acatggcctg
     7081 atatttctgg agggtacacg aagcaagtct tgttcattac ttctgtgtta cttcagaact
     7141 agactcctgg ttgccagaac acagtgtctc tgagtaaaac actggtcttt ggaactcagc
     7201 attggattct acctggtcat actgaagacc gagttgcaaa aagagtctcc cttcctcctg
     7261 ttgacaacgg agttaatcca cacaaaaaga cacggggact ccctcgtgta aacatccaca
     7321 cggttccgct ttcctaataa gacgtgcaaa tatgacatgt tggcaggaac gtaggtaaac
     7381 tggattgcat tcatgctgtt cacaccacag acgggcaaaa cgaaatgagt tttcccccag
     7441 gtgtagctcg atcaagctgt gctaaccgta cagaaagacg ctctttacgc cactgaaatt
     7501 aaatagtcag tgggtcttga aaaatattta gatgaattgc agctagctgc aaggatggaa
     7561 ttaattcctc ccattcttca cattaaaatt ctgaagactc cccgcccctc ccccttcttt
     7621 taagcatagc aacttggagt cagtaaaggt ggccatagcg taaacctata gatggtgctt
     7681 taaaacaaaa tcgtatcttt cttaatagca gtatttttta aagcagagaa tagactgaaa
     7741 gaagtaaatg cggcagaacg ctgttccaca ctcaggtaaa ttttgtggtt tattaaaatg
     7801 ccaataatat ttgtgcactt gccagcgtca ggggcttttc ccttaatgga tgctctcggt
     7861 gtgatttttt tcctcttctt taactgtatc gttacattgt ttagagagca tccaccacca
     7921 ggatttgcca ccgtagtgat aactagcatt aggaaagaat taccgagaac tgagggtcaa
     7981 accactttca tcacctaaac gacaggcact agttctttag tatttcttca gtggcttggg
     8041 tgtgcccatg tattcaaagc attccgcacg aattttacca gttaaatacc ggctgaaaag
     8101 tcagaccagt ctctctccgc acctcctctc tctgtaacaa tgtttcgttt ttgttttgtt
     8161 tttttcccat aatgagctgt ctgtgttctt ttgttatttc aaactttggt tcaagtggta
     8221 gcaatggtac acactgtgat ggtggggaga ctagctgggt gagtctctag tgtgtgatct
     8281 aatctttaca tgggtgtgct atctgtgggt gttgataact ggaactgtac ccggacaaca
     8341 cgacagtttc tctctcttcc tgttcctgat tcactactat atcatagtac gtgggtatga
     8401 cccctgcgag tatccacacc gaagcctatg tattccacaa ttgtaacctg aaagaccatg
     8461 cattatcttt ttttaattca tactggtgtt tgtgttattt aaagtggaaa attataccct
     8521 atctagtagt ataatgtaat ataataggat actccgctgt gcacagttcc aagtgcctta
     8581 gaacattgtt tagctttcct aagtatacgt aaatgcatat atgtgtgtat aaaattggga
     8641 aatgttacct caataaagtc attgggaaat ccta
//
LOCUS       NM_001437862            3600 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 13, mRNA.
ACCESSION   NM_001437862 XM_008770498
VERSION     NM_001437862.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3600)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3600)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3600)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3600)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3600)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3600)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3600)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3600)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3600)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3600)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770498.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.44590.1,
                                           SRR26643285.39724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1167           JAXUCZ010000015.1  3601575-3601619
            1168-1216           JAXUCZ010000015.1  3604223-3604271
            1217-1292           JAXUCZ010000015.1  3607566-3607641
            1293-1387           JAXUCZ010000015.1  3607997-3608091
            1388-1632           JAXUCZ010000015.1  3609598-3609842
            1633-3600           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3600
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1620
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 13 is encoded by transcript variant 13;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 13"
                     /protein_id="NP_001424791.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKIT
                     EQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHT
                     TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCS
                     GAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1219..1602
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1219..1602
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1167
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1216
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1292
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1387
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1632
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..3600
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca aggagccaca aaccaccgtg
     1141 gtacataatg ctacagatgg gatcaagggc tccacagaga gctgcaacac caccacagaa
     1201 gacgaagatc tcaaagtgcg aaaacaggag atcattaaga tcacagaaca gctgatagaa
     1261 gccatcaaca atggggactt tgaggcctac acgaagattt gtgacccagg cctcacttcc
     1321 tttgagccag aagcccttgg taacctcgtg gaggggatgg atttccataa gttttacttt
     1381 gagaatctcc tgtccaagaa cagcaagcct atccacacca ccatcctaaa cccacatgtc
     1441 catgtcatcg gcgaggacgc agcttgcatc gcctacatcc ggctcaccca gtacatcgat
     1501 gggcagggtc ggcctcgcac cagtcagtca gaggagaccc gggtgtggca ccgccgggat
     1561 ggcaagtggc tcaatgtcca ctatcactgc tcaggagccc ctgctgcacc gctgcagtga
     1621 gctcaggcac aggggcatta ggagattcca gctggaggct gaaccttcga agtcagtgac
     1681 tctggagggc ctgagtgaca gccgcggtcc tgtccatttg aggtttaaaa caattacatt
     1741 acaaagcggc agcagccaat gcacgcccct gcatgcagcc ctcccgcccg cccttcgtgt
     1801 ctgtctctgc tgtactgagg tgttttttac atttaagaaa aaaaaaagaa aataagattg
     1861 ttttaaaaaa aaatggaatt cataccatga tgcgttttaa aacaactgat agcctttggg
     1921 cttgaagaag gcaggagttt gtatgatgct catccaggcg tgaacagagg gctcacccac
     1981 tggctttgaa gaggtgagct tggcctcagg cccccatgga ctcggggggg accaggcaag
     2041 gactcttgac agagctttgg tcatggacag agccatgctg tggttgcagc cccggtggtg
     2101 acctgatcac tccaggtcta ggagtggact tcttcagaat atacattgac acctagtatg
     2161 agaaagaaga aaactccatg gctaacagac ctacttggga gagaacgcag cgctcccagc
     2221 ccgctgtgga ggcaactgtg aagcgtggcc tcgggactga aggcctggac tttgccgtac
     2281 cgttccagtt agtgtagaca ggaagagaat tggtgctgca gaagtgtgtc cgacacagag
     2341 ccggtgtgaa acctcgcgtt agtctgacac gcacttactc atccatttct ataggatgca
     2401 caatgcacgt gggcctgaga ctgaggcctg atttctgcag gcgagaaggg ggtgggattg
     2461 ctactttgtt tcctgttggt tttcctaatg tatcaaggag agatccagac atcgttggcc
     2521 agggctcctg ttgccacttt ctgcagttgt gtttgtgtgc ggatctggac cactttgtct
     2581 tatattttcg tggcggtggt ccccatgccg accctctgcc aagtgcccct gcgggatggg
     2641 aggagtgaga taagagttgg tggttgtttc tatgcattct ggctgccctc tgggctgcct
     2701 cccttcttcc cgtgctgcac gtccgtctct ttccctgagt ttgagattga accgactgct
     2761 tgggtgagaa gtgtcctctt taatgaggct ctctaccgac caactgaagt atagactttt
     2821 ctgctggaca atctgcatgg gcatcacccc ctcacctgca tgtacccaaa aaggggtcca
     2881 gagccaaggc tcctgtagtc attgtccctc tctgtgctca aggagttcct ttccaggagg
     2941 aaaagatctg taccttaggc agataacaga gaagacaatg gaggagcaat tggtcatagt
     3001 cttggttccc tcccacccaa cagctgcaca ctatctgcat tttggggggg aaggtgggtt
     3061 gacttcagct ctttggatga ccttcaggga ggcacaggag ctgggaaaag atacagaact
     3121 acagactttg gaaccagctg agaagagaac aaactcatgg gtgctggtgc ttgaatttag
     3181 ccaggctcct caagcacctt gtgcatgcct cagaccctgg accctagccc cttcctgccc
     3241 tgcagcctgc agtgccagcc aacagatccc ttcaccacag ggtttggttt tgctggcttg
     3301 aagacaacaa atggtcttag agctcattga gacccatagc ttcatatggc tgctccagcc
     3361 ccacttagcg ttcttactcc acttctgggg ctaatgtcag catctataga caattaatag
     3421 actatttaaa aaaaaaaacc accttttaaa caggaaatga aaggcatttg atgcagaact
     3481 tttgcatgac gacatagaaa taatttaaaa atagtgtttg ttctgaatgt tggtagtccc
     3541 ttcatagctt tgttacaatg aaaccttgaa gatatttaat aaaataacct ttaaacagtc
//
LOCUS       NM_001437854            3720 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 4, mRNA.
ACCESSION   NM_001437854 XM_008770491
VERSION     NM_001437854.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3720)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770491.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2023173.1,
                                           SRR26643298.56237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1128           JAXUCZ010000015.1  3600390-3600458
            1129-1173           JAXUCZ010000015.1  3601575-3601619
            1174-1222           JAXUCZ010000015.1  3604223-3604271
            1223-1336           JAXUCZ010000015.1  3605519-3605632
            1337-1412           JAXUCZ010000015.1  3607566-3607641
            1413-1507           JAXUCZ010000015.1  3607997-3608091
            1508-1752           JAXUCZ010000015.1  3609598-3609842
            1753-3720           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3720
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1740
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 4 is encoded by transcript variant 4;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 4"
                     /protein_id="NP_001424783.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKPQSN
                     NKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGN
                     GSLVPEGRSPRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKI
                     CDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIA
                     YIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1339..1722
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1339..1722
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1128
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1173
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1222
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1336
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1412
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1507
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1752
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..3720
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaagc cacagagcaa caacaaaaac
     1081 agtctcgtaa gcccagccca agagcccgcg cccttgcaga cggccatgga gccacaaacc
     1141 accgtggtac ataatgctac agatgggatc aagggctcca cagagagctg caacaccacc
     1201 acagaagacg aagatctcaa agctgccccg ctccgcactg ggaatggcag cttggtgcct
     1261 gaaggacgga gcccccggga cagaacagcc ccctctgcag gcatgcagcc ccagccttct
     1321 ctctgctcct cagccatgcg aaaacaggag atcattaaga tcacagaaca gctgatagaa
     1381 gccatcaaca atggggactt tgaggcctac acgaagattt gtgacccagg cctcacttcc
     1441 tttgagccag aagcccttgg taacctcgtg gaggggatgg atttccataa gttttacttt
     1501 gagaatctcc tgtccaagaa cagcaagcct atccacacca ccatcctaaa cccacatgtc
     1561 catgtcatcg gcgaggacgc agcttgcatc gcctacatcc ggctcaccca gtacatcgat
     1621 gggcagggtc ggcctcgcac cagtcagtca gaggagaccc gggtgtggca ccgccgggat
     1681 ggcaagtggc tcaatgtcca ctatcactgc tcaggagccc ctgctgcacc gctgcagtga
     1741 gctcaggcac aggggcatta ggagattcca gctggaggct gaaccttcga agtcagtgac
     1801 tctggagggc ctgagtgaca gccgcggtcc tgtccatttg aggtttaaaa caattacatt
     1861 acaaagcggc agcagccaat gcacgcccct gcatgcagcc ctcccgcccg cccttcgtgt
     1921 ctgtctctgc tgtactgagg tgttttttac atttaagaaa aaaaaaagaa aataagattg
     1981 ttttaaaaaa aaatggaatt cataccatga tgcgttttaa aacaactgat agcctttggg
     2041 cttgaagaag gcaggagttt gtatgatgct catccaggcg tgaacagagg gctcacccac
     2101 tggctttgaa gaggtgagct tggcctcagg cccccatgga ctcggggggg accaggcaag
     2161 gactcttgac agagctttgg tcatggacag agccatgctg tggttgcagc cccggtggtg
     2221 acctgatcac tccaggtcta ggagtggact tcttcagaat atacattgac acctagtatg
     2281 agaaagaaga aaactccatg gctaacagac ctacttggga gagaacgcag cgctcccagc
     2341 ccgctgtgga ggcaactgtg aagcgtggcc tcgggactga aggcctggac tttgccgtac
     2401 cgttccagtt agtgtagaca ggaagagaat tggtgctgca gaagtgtgtc cgacacagag
     2461 ccggtgtgaa acctcgcgtt agtctgacac gcacttactc atccatttct ataggatgca
     2521 caatgcacgt gggcctgaga ctgaggcctg atttctgcag gcgagaaggg ggtgggattg
     2581 ctactttgtt tcctgttggt tttcctaatg tatcaaggag agatccagac atcgttggcc
     2641 agggctcctg ttgccacttt ctgcagttgt gtttgtgtgc ggatctggac cactttgtct
     2701 tatattttcg tggcggtggt ccccatgccg accctctgcc aagtgcccct gcgggatggg
     2761 aggagtgaga taagagttgg tggttgtttc tatgcattct ggctgccctc tgggctgcct
     2821 cccttcttcc cgtgctgcac gtccgtctct ttccctgagt ttgagattga accgactgct
     2881 tgggtgagaa gtgtcctctt taatgaggct ctctaccgac caactgaagt atagactttt
     2941 ctgctggaca atctgcatgg gcatcacccc ctcacctgca tgtacccaaa aaggggtcca
     3001 gagccaaggc tcctgtagtc attgtccctc tctgtgctca aggagttcct ttccaggagg
     3061 aaaagatctg taccttaggc agataacaga gaagacaatg gaggagcaat tggtcatagt
     3121 cttggttccc tcccacccaa cagctgcaca ctatctgcat tttggggggg aaggtgggtt
     3181 gacttcagct ctttggatga ccttcaggga ggcacaggag ctgggaaaag atacagaact
     3241 acagactttg gaaccagctg agaagagaac aaactcatgg gtgctggtgc ttgaatttag
     3301 ccaggctcct caagcacctt gtgcatgcct cagaccctgg accctagccc cttcctgccc
     3361 tgcagcctgc agtgccagcc aacagatccc ttcaccacag ggtttggttt tgctggcttg
     3421 aagacaacaa atggtcttag agctcattga gacccatagc ttcatatggc tgctccagcc
     3481 ccacttagcg ttcttactcc acttctgggg ctaatgtcag catctataga caattaatag
     3541 actatttaaa aaaaaaaacc accttttaaa caggaaatga aaggcatttg atgcagaact
     3601 tttgcatgac gacatagaaa taatttaaaa atagtgtttg ttctgaatgt tggtagtccc
     3661 ttcatagctt tgttacaatg aaaccttgaa gatatttaat aaaataacct ttaaacagtc
//
LOCUS       NM_001437837            4104 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 6, mRNA.
ACCESSION   NM_001437837 XM_063281281
VERSION     NM_001437837.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4104)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4104)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4104)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4104)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4104)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4104)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4104)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4104)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4104)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063281281.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.992584.1,
                                           SRR26360194.249395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217877711-217877783
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1502           JAXUCZ010000002.1  217914468-217914509
            1503-1551           JAXUCZ010000002.1  217916935-217916983
            1552-1627           JAXUCZ010000002.1  217946550-217946625
            1628-1722           JAXUCZ010000002.1  217955065-217955159
            1723-1951           JAXUCZ010000002.1  217957098-217957326
            1952-4104           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4104
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1955
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 6 is encoded by transcript variant 6;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 6"
                     /protein_id="NP_001424766.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPIN"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1371..1373
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1425..1541
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1509..1511
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1515..1517
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1527..1529
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1502
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1551
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1627
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1722
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1951
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..4104
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgcattcag cagatcctgg
      781 aggctgtgct acactgccat cagatgggcg tagtccatcg ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagccccaaa ctactgtaat ccacaaccct gatggaaaca
     1501 aggagtcaac tgagagctca aataccacca ttgaggatga agacgtgaaa gcacgaaagc
     1561 aagagatcat caaagtcact gagcagctga ttgaagctat caacaatggg gacttcgagg
     1621 cttacacgaa aatctgtgat ccaggcctca ctgcctttga acccgaagca ttgggcaact
     1681 tagtggaagg gatggacttt cacagattct actttgaaaa tgctttgccc aaaatcaata
     1741 aaccaatcca cactatcatc ctgaaccctc acgtacacct ggtaggggat gatgcagcct
     1801 gcatagcata cattcggctc acacagtaca tggatggaaa tggaatgcca aagacaatgc
     1861 agtcagaaga gactcgagtg tggcaccgcc gtgatgggaa gtggcagaat attcactttc
     1921 atcgttcggg gtccccaaca gtccccatca actaattgtc aacagtgcca cgtcttcatt
     1981 ctgtcctcaa ggcacctggc ggggtgatcc tgggacatcc tctcctcttc atgcatgttt
     2041 ctgagtgcat gaagttgtga aggttctacg tgtaatgcat atgtgacacg tcatcttacc
     2101 atgtgacacg ccatcttacc atgtattcct tcctgtacat tgtttacact ccagctactg
     2161 gacggatgtt ccatgcaaac gtcagttact gctggcaaac taaagaggga gctccgacaa
     2221 gaaaactccg caatactcca agttcagctg atccatcagg tttctctgtg gatgccaaga
     2281 ttcaaaagac ttcataaaat tactgttcaa tgaatgacag tgtgtaagag gaaaggaaat
     2341 ctttcaagaa tgctgccatt aatctatttg ggcttctcat tgggattttg gggttgattt
     2401 ttttttcatt ttttaaggca aatatatata tatatatata tatatatata tatatatata
     2461 tatatatata tatgccttca gttcctggta gaaatgaatg gatgcctttt ctctgaaagt
     2521 gttggtgttg gataaatgga tggctatgtg agccaagtcc tgggtgattg taggagcaag
     2581 aatcgtttgc tgttctacca tcaaagccat gttgatttgg gtcgagctct gtatactgga
     2641 aaaattcaca tcattttcta gtttgattgc tttcagatag gcacagttct ggtgaatgct
     2701 tggcactgat cttggttttt ctttcctaaa tctgtgttct gttttcatta tatactattt
     2761 gctcctttcc tttgtatttg ttttcttttc ccactctttt ctttatcttt ctctctccca
     2821 ctttctttct tttttatgtt ttcctttcta tagctgatag tgtgtaaaaa cagtaacatt
     2881 tgcatatgaa gttaaaataa aaatcaaggt cttctagaag ctaaaactag cacttccggt
     2941 ctctcacggg gctgtggagt tgttagaaga tttaaataaa tacttaaata agagaggaat
     3001 gaattcagct taggttacca cttgtgcata ggtatccttg ctctgttgaa agtgttggaa
     3061 ttgttgagac ttaagctaac agcagtaaga gcctgcttac acagtcctgg ttctccccaa
     3121 ctagatattg aagaccaagt ggagcctgac cagggttgca tgcagagcac ttgttttgga
     3181 ccttccagac taggaggcat ttactgcctc actttcacta gctagccaca ggaagagtgt
     3241 tctccatcct cctagaggtt gaacttgacc ttcgtgacta gtgcagttct agcttctctc
     3301 ttgagtcaca gtagcatcct gatgccagga gttaggcttt tgtccagatt aaaacaacga
     3361 ggaaaaggaa atgccccagt tttctttccg tttcccattt cttctttgtc gattcggtcc
     3421 ctgggagact gtttctccgc gctgaactgc tttatggtgc atggaatctc catcagcgta
     3481 cttctaccct agccactcac actccttaga agctgatttt taaagcagaa gcaaggaagc
     3541 aaaagtaaaa cactcccttc ccctcttttt cctcatttca ccttttggtg ttgattgcta
     3601 atcactttag atatattgtt gctagtgaat gtatgataga tgggttgaag cttttctgat
     3661 aattagcaca tgatttaaaa caatatatat ttaaaacaaa tatatacagt acatgtattg
     3721 agccgtgtta acctgccaat gagatctgtg aaaaacgtaa tggcctcact tttccctttg
     3781 aatttctttt acctttctgt gaagcagctc tgcgtggcat acatgtattt aaaaacacaa
     3841 atagtggtag aatgggtttt ttttttacac ttttaactta gcatgtggtg ttgaagtatt
     3901 accatagatc cagtttgtct tctgcactaa gatgtgagga aatcgtgatt tgttctctcc
     3961 agcacagtgg aattacacct tcatcatctt ctattgtttt gaaaacactg cagtttacca
     4021 tgggacactg tatataattc ttgccgtaat ggtaaatgac aaattgatat atttaagagt
     4081 taataaattt gtgatttctg ctga
//
LOCUS       NM_013115               4761 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus prostaglandin F receptor (Ptgfr), transcript
            variant 1, mRNA.
ACCESSION   NM_013115 XM_579372
VERSION     NM_013115.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4761)
  AUTHORS   Fukuda,M., Aoki,T., Manabe,T., Maekawa,A., Shirakawa,T.,
            Kataoka,H., Takagi,Y., Miyamoto,S. and Narumiya,S.
  TITLE     Exacerbation of intracranial aneurysm and aortic dissection in
            hypertensive rat treated with the prostaglandin F-receptor
            antagonist AS604872
  JOURNAL   J Pharmacol Sci 126 (3), 230-242 (2014)
   PUBMED   25341845
  REMARK    GeneRIF: Prostaglandin F-receptor antagonist AS604872 exacerbates
            vascular inflammation in hypertensive animals, facilitating
            intracranial aneurysm formation and aortic dissection.
REFERENCE   2  (bases 1 to 4761)
  AUTHORS   Anadol,E., Kanca,H., Yar,A.S., Helvacioglu,F., Menevse,S.,
            Calguner,E. and Erdogan,D.
  TITLE     Prostaglandin F receptor expression in intrauterine tissues of
            pregnant rats
  JOURNAL   J Vet Sci 15 (1), 125-131 (2014)
   PUBMED   24136214
  REMARK    GeneRIF: There was an increase rat prostaglandin F receptor
            expression in rat uterus with advancing gestation, a marked
            elevation of expression at term, and a concominant decrease during
            the postpartum period.
REFERENCE   3  (bases 1 to 4761)
  AUTHORS   Ueno,T. and Fujimori,K.
  TITLE     Novel suppression mechanism operating in early phase of
            adipogenesis by positive feedback loop for enhancement of
            cyclooxygenase-2 expression through prostaglandin F2alpha receptor
            mediated activation of MEK/ERK-CREB cascade
  JOURNAL   FEBS J 278 (16), 2901-2912 (2011)
   PUBMED   21668646
REFERENCE   4  (bases 1 to 4761)
  AUTHORS   Suzuki-Yamamoto,T., Toida,K., Sugimoto,Y. and Ishimura,K.
  TITLE     Colocalization of prostaglandin F(2alpha) receptor FP and
            prostaglandin F synthase-I in the spinal cord
  JOURNAL   J Lipid Res 50 (10), 1996-2003 (2009)
   PUBMED   19429887
  REMARK    GeneRIF: Data found that FP localizes in neuronal somata and
            dendrites but not in ependymal cells, tanycytes, or endothelial
            cells. Immunohistochemical analysis of serial sections showed the
            colocalization of FP and PGFS I.
REFERENCE   5  (bases 1 to 4761)
  AUTHORS   Almirza,W.H., Dernison,M.M., Peters,P.H., van Zoelen,E.J. and
            Theuvenet,A.P.
  TITLE     Role of the prostanoid FP receptor in action potential generation
            and phenotypic transformation of NRK fibroblasts
  JOURNAL   Cell Signal 20 (11), 2022-2029 (2008)
   PUBMED   18703136
  REMARK    GeneRIF: Activity of PGF(2alpha) by putative pacemaker cells
            underlies the generation of calcium action potentials in normal rat
            kidney monolayers.
REFERENCE   6  (bases 1 to 4761)
  AUTHORS   Yonekura,H., Sakurai,S., Liu,X., Migita,H., Wang,H., Yamagishi,S.,
            Nomura,M., Abedin,M.J., Unoki,H., Yamamoto,Y. and Yamamoto,H.
  TITLE     Placenta growth factor and vascular endothelial growth factor B and
            C expression in microvascular endothelial cells and pericytes.
            Implication in autocrine and paracrine regulation of angiogenesis
  JOURNAL   J Biol Chem 274 (49), 35172-35178 (1999)
   PUBMED   10575000
REFERENCE   7  (bases 1 to 4761)
  AUTHORS   Olofsson,J.I., Leung,C.H., Bjurulf,E., Ohno,T., Selstam,G., Peng,C.
            and Leung,P.C.
  TITLE     Characterization and regulation of a mRNA encoding the
            prostaglandin F2alpha receptor in the rat ovary
  JOURNAL   Mol Cell Endocrinol 123 (1), 45-52 (1996)
   PUBMED   8912810
REFERENCE   8  (bases 1 to 4761)
  AUTHORS   Orlicky,D.J.
  TITLE     Negative regulatory activity of a prostaglandin F2 alpha receptor
            associated protein (FPRP)
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 54 (4), 247-259 (1996)
   PUBMED   8804121
REFERENCE   9  (bases 1 to 4761)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
REFERENCE   10 (bases 1 to 4761)
  AUTHORS   Kitanaka,J., Hasimoto,H., Sugimoto,Y., Negishi,M., Aino,H.,
            Gotoh,M., Ichikawa,A. and Baba,A.
  TITLE     Cloning and expression of a cDNA for rat prostaglandin F2 alpha
            receptor
  JOURNAL   Prostaglandins 48 (1), 31-41 (1994)
   PUBMED   7972878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_013115.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN16093047
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000002.1  243425564-243425623 c
            61-931              JAXUCZ010000002.1  243423769-243424639 c
            932-4761            JAXUCZ010000002.1  243391590-243395419 c
FEATURES             Location/Qualifiers
     source          1..4761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..4761
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F receptor"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
     exon            1..60
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     exon            61..931
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    89..91
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="upstream in-frame stop codon"
     CDS             134..1234
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="PGF receptor; prostanoid FP receptor; PGF2-alpha
                     receptor"
                     /codon_start=1
                     /product="prostaglandin F2-alpha receptor"
                     /protein_id="NP_037247.1"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
                     /translation="MSINSSKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSN
                     SLAIAILMKAYQRFRRKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFD
                     QSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLFHSTKITSKHVKMILSGVC
                     MFAVFVALLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLALGISFS
                     CNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAING
                     NNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWE
                     LSSIKNSLKVAAISESPAAEKENQQASSEAGL"
     misc_feature    143..145
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P43118.1); glycosylation site"
     misc_feature    188..190
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P43118.1); glycosylation site"
     misc_feature    212..1081
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F2-alpha receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_FP; cd15145"
                     /db_xref="CDD:320273"
     misc_feature    212..1081
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F2-alpha receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_FP; cd15145"
                     /db_xref="CDD:320273"
     misc_feature    215..295
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320273"
     misc_feature    215..295
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320273"
     misc_feature    227..298
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    329..409
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320273"
     misc_feature    329..409
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320273"
     misc_feature    341..403
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    order(395..397,404..409,455..472,476..481,488..490,
                     623..625,629..643,722..724,731..739,743..751,755..760,
                     917..919,926..931,935..940,947..949,977..982,986..994,
                     1001..1003,1010..1015)
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320273"
     misc_feature    order(395..397,404..409,455..472,476..481,488..490,
                     623..625,629..643,722..724,731..739,743..751,755..760,
                     917..919,926..931,935..940,947..949,977..982,986..994,
                     1001..1003,1010..1015)
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320273"
     misc_feature    455..547
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320273"
     misc_feature    455..547
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320273"
     misc_feature    461..526
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    581..649
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320273"
     misc_feature    581..649
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320273"
     misc_feature    590..658
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    722..811
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320273"
     misc_feature    722..811
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320273"
     misc_feature    728..805
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    857..949
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320273"
     misc_feature    857..949
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320273"
     misc_feature    884..934
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    980..1057
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320273"
     misc_feature    980..1057
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320273"
     misc_feature    989..1054
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     exon            932..4761
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaatgttg caagctgagg ccccttgggg gtgtgggctc tgtaactggc aaagtcaact
       61 atgtctgcac ttcgaggctg cacagtcgtg acagagagat gacttgaggg ggacggcgtt
      121 tatctccaca acgatgtcca taaacagttc caagcagccg gcgtcctctg cagctggact
      181 catcgccaac acgacttgcc agacggagaa ccggctttca gtgttctttt caataatctt
      241 catgacggtg gggattgtat ctaacagcct ggccattgcc atcctcatga aggcatatca
      301 gagatttaga cggaagtcga aggcttcttt cctgctcttg gctagtggcc tggtgatcac
      361 agacttcttc ggccacctca tcaacggagg gatagctgtc ttcgtatacg cttctgataa
      421 agactggatc cgcttcgatc aatcgaacat cctgtgcagt gtttttggga tctccatggt
      481 gttctctggc ttgtgcccac ttttcctggg cagtacgatg gccattgaga ggtgcatcgg
      541 ggtcaccaac cctctattcc actctacaaa gatcacgtct aagcatgtga aaatgatact
      601 gagcggtgtg tgcatgtttg ctgtcttcgt ggccctgttg cccatccttg gacaccgaga
      661 ttatcaaatc caagcatcca gaacttggtg cttctacaac acagagcaca tcgaagactg
      721 ggaagacagg ttctatctct tgttcttttc ttccctggga ctcttagctc tcggcatctc
      781 attctcgtgc aacgccgtca cgggagtcac acttttgaga gtgaagttta gaagtcagca
      841 gcacaggcaa ggcaggtctc accacctgga gatggtcatt cagctcctgg ccataatgtg
      901 tgtctcctgc gtctgctgga gtccctttct ggtgacgatg gccaacattg caatcaatgg
      961 aaataattcc ccagtgacct gtgagacgac gctctttgct ctccgaatgg caacctggaa
     1021 ccagatatta gacccctggg tctacattct gctacggaag gctgtcctta ggaacctgta
     1081 caagcttgcc agtcgctgct gtggagtgaa catcatcagc ttgcacatct gggaactcag
     1141 ctccatcaag aattccttaa aggttgctgc tatctctgag tcaccggctg cagagaagga
     1201 gaatcagcaa gcatctagtg aggctggact gtaagtcaat gcacagctag aagaaagtta
     1261 tgggaacttc cgaaacatct tacctgacca gactcagagc ataactggaa cacttggacc
     1321 tctgtgtgta gttcaggagt acactggtca gacaaagctt ctgacttttg ttatgctggc
     1381 tgctgcatgg ttgtgcattt tcatttgttg gtgtcaacag gagattcaac atggtggagt
     1441 taagtagagt acacatttta tctgcgtgac ttatgttttt ggaataaatg aatctgttga
     1501 ggccctgtgc ctttatttga cctatttttc caagcacctt aatgctacct gcaccgtgac
     1561 atggccattt gaggagcact gacttgcaga caaagcttaa agtaacacaa gactttttgt
     1621 gtttgtgtgt gcagctctgc tctgtttacc aacccacgtg tcctcaatgt ctgcatgacc
     1681 atgacatctg agtctcgtgg tgactttgat ggccactatg taggcagctc agcttgacat
     1741 tgtggggctg atgaggataa tcattcttgt cacaactcac atgtgtggtt gcttgcattt
     1801 gttgttgtga aggtcaatta ttttttccac attggctgtc ctcctataaa gtcataggtt
     1861 ttcagtgtct aagtaatccc cctttcctct gaaaattgta gaggaataca ggctttatct
     1921 tagcacagat tcagctcatg atagcatatc ataagcccta ttgtggatga tgcaaacatt
     1981 gaaatcccac ttacacatgc caagaacatg gcagacattg ctttacctga gctatcattt
     2041 ctgtgtcaga gaataaaaaa cgatcaagac acattcgaag tctcttggag ctattgtgtt
     2101 tctgccttac acacacaggc ataagggagt tctgttaaca gtaatttcac taaataagtt
     2161 gaaccacact tccaaaagcc tgtgttatca gtgaggagtg gaaagatctg aaattagcca
     2221 ggagttggga tccactgttg tggttaaccc gaggctaagg gacaagattc tgtcgccaag
     2281 tttcccaatc ttaattcaca cttctccttt gtataattta acacaaagat actcaatttc
     2341 agtaatcact ctaaacatta gttccatcag tgactacggt tagtggttat attttataaa
     2401 gaaatgtatt ttcatattta aaaaattcct ttcttttatc gtttgtcttt atttaaaaat
     2461 ttctattttt ttctttgcta tgtgtatgag tgtttcaccc gaatgtattt ccgagcatta
     2521 cgtaccttcc tagaacttac ttaaaccaga aaaggacatc gggtccttac agatggttat
     2581 aagctaccat gtggatacta ggaattgagc ccaggttctc tggaagagca gctgtagaga
     2641 gaattttaat ccagcaattt gtgaattcaa tagacttaaa atagtacctc caacatggtt
     2701 tctctggcaa aagatcacat ccgaagagct tctaggttta tatgatctgg cttgaatgca
     2761 gacattctct ggattatagt acaatctggc tgtaacacag acacaccctt agtacacacc
     2821 tttaatccct aacagtgaag gaaagttagt ttgtagaagg aagtagtcac ttttgaaatc
     2881 gatgtccagt tgagggtcag acagagtgac gaatcagaga aagttttgac agaatgagtt
     2941 agagaaagga tgtgctcaat tcacgtgaga acagtacgga aagagaggat gccgaaaagg
     3001 ggagagagag agagagagag agagagagag agagagagag agagagaggg aggaagaagg
     3061 aggaggagga agaggaggag gaggaggatg aagataagga ggaagaggaa gaagggagga
     3121 gtgagaggag ggggaggagg aggagggact gcggtgtgtg tttatggtac caggacagat
     3181 ttatatagtt tggctgtagg gagaacaagc tggatacagg tgaagacaga gcaaaccaaa
     3241 aaatgagaag gagccagaag agtagacctt attgacaaag ttcgtatgag gccaagcaag
     3301 caatcaggca gaagtggaga gaagccagac tgaatcagtc agcttggaag attagattgt
     3361 ttggaggata gacgctttca ggcctaggcc tagggataat tagaacagag aaagaagtgc
     3421 tctgggctca gcctaagctg tgtatccaca gagctagaaa acaggtttca tcccatccct
     3481 tcatctgagg aaataaaggc atcattttca agtgctgctt aactgctgag ccatctctcc
     3541 agcctttcaa aactgttttt atctgtaaaa ataattttgg attctaggaa tcctgtaaac
     3601 tcaacaaaat agtattttta aaaacctctg cttttgattg gtagcttaca ttggatatga
     3661 ttactgcttt tggtaaattc tcattagtaa attaaaagaa attaagcaaa cagcctcgtt
     3721 gaagacttaa agaaaattat ttgtagtgat ttgaaaggag tacacactat catgtgataa
     3781 tcttaattta aaggcaagtg atcaatcaca cagttgattc ttatgtagag aatatgtcag
     3841 agaatagaca acaatttttg gtgtaaattt agcacggggt tgtaaagaat gtgcccagtt
     3901 taagtgtaag ctgataccta tatgtgggtt attgtgatgt agatatgtat acatatatgt
     3961 atgtaagttc ccctgtgcat gcatgtgttt atgaatatgt gtgtatatgt atgtgtatat
     4021 atgtataatg catatgattg taaaaggcat tacaatttat gattaatgtt acattacata
     4081 agtgttatca tttttaactt caagagtact caaagtttgg aaaaccattt ggtcacttca
     4141 cgcactttca gagcagattt ctttcctaca gcaataagat gttgctatct cacaaactga
     4201 ggctcaaaga accaaatctc tgtctttcct aattatagtt tgcataactc tgcaatgaac
     4261 attggcatgt attccaactg aggaaaggta gtaagaagga acttcgagac tccaggtctc
     4321 ttcatagagc ctctgataca gacacaattg ttcttctacc tactttgatg tctacaatga
     4381 gaccatcttt taacatcatg ctgtgctgaa ggcaaggctc tgggaagagc caaggagtta
     4441 ctcagtgcat attctggaag atttatccat gctacttgag cataccgttt aggcaaaaaa
     4501 aaaaaaaacc caaaaaaaca gaagaacaaa acaaaatgaa aaactgatct taagatgagg
     4561 ataaacccac agtgtaaata taaaaaattg aaaaagtttc atgttatacc tgactctaaa
     4621 attctgtttg ttatagtgcc tgttgtacct agtttactgt acagtgagcg atagagaatg
     4681 tgctcactga taacttccat agggctgagt agaagtgtgc tttttcttag cccttaaaat
     4741 aaagagtaca agtagtgcca a
//
LOCUS       NM_001437841            4062 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 10, mRNA.
ACCESSION   NM_001437841 XM_039101696
VERSION     NM_001437841.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4062)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4062)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4062)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4062)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4062)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4062)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4062)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4062)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4062)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039101696.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1010564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1509           JAXUCZ010000002.1  217916935-217916983
            1510-1585           JAXUCZ010000002.1  217946550-217946625
            1586-1680           JAXUCZ010000002.1  217955065-217955159
            1681-1909           JAXUCZ010000002.1  217957098-217957326
            1910-4062           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4062
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1913
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 10 is encoded by transcript variant 10;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 10"
                     /protein_id="NP_001424770.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKI
                     CDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIA
                     YIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIN"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1509
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1585
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1680
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1909
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..4062
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagtcaactg agagctcaaa taccaccatt gaggatgaag
     1501 acgtgaaagc acgaaagcaa gagatcatca aagtcactga gcagctgatt gaagctatca
     1561 acaatgggga cttcgaggct tacacgaaaa tctgtgatcc aggcctcact gcctttgaac
     1621 ccgaagcatt gggcaactta gtggaaggga tggactttca cagattctac tttgaaaatg
     1681 ctttgcccaa aatcaataaa ccaatccaca ctatcatcct gaaccctcac gtacacctgg
     1741 taggggatga tgcagcctgc atagcataca ttcggctcac acagtacatg gatggaaatg
     1801 gaatgccaaa gacaatgcag tcagaagaga ctcgagtgtg gcaccgccgt gatgggaagt
     1861 ggcagaatat tcactttcat cgttcggggt ccccaacagt ccccatcaac taattgtcaa
     1921 cagtgccacg tcttcattct gtcctcaagg cacctggcgg ggtgatcctg ggacatcctc
     1981 tcctcttcat gcatgtttct gagtgcatga agttgtgaag gttctacgtg taatgcatat
     2041 gtgacacgtc atcttaccat gtgacacgcc atcttaccat gtattccttc ctgtacattg
     2101 tttacactcc agctactgga cggatgttcc atgcaaacgt cagttactgc tggcaaacta
     2161 aagagggagc tccgacaaga aaactccgca atactccaag ttcagctgat ccatcaggtt
     2221 tctctgtgga tgccaagatt caaaagactt cataaaatta ctgttcaatg aatgacagtg
     2281 tgtaagagga aaggaaatct ttcaagaatg ctgccattaa tctatttggg cttctcattg
     2341 ggattttggg gttgattttt ttttcatttt ttaaggcaaa tatatatata tatatatata
     2401 tatatatata tatatatata tatatatata tgccttcagt tcctggtaga aatgaatgga
     2461 tgccttttct ctgaaagtgt tggtgttgga taaatggatg gctatgtgag ccaagtcctg
     2521 ggtgattgta ggagcaagaa tcgtttgctg ttctaccatc aaagccatgt tgatttgggt
     2581 cgagctctgt atactggaaa aattcacatc attttctagt ttgattgctt tcagataggc
     2641 acagttctgg tgaatgcttg gcactgatct tggtttttct ttcctaaatc tgtgttctgt
     2701 tttcattata tactatttgc tcctttcctt tgtatttgtt ttcttttccc actcttttct
     2761 ttatctttct ctctcccact ttctttcttt tttatgtttt cctttctata gctgatagtg
     2821 tgtaaaaaca gtaacatttg catatgaagt taaaataaaa atcaaggtct tctagaagct
     2881 aaaactagca cttccggtct ctcacggggc tgtggagttg ttagaagatt taaataaata
     2941 cttaaataag agaggaatga attcagctta ggttaccact tgtgcatagg tatccttgct
     3001 ctgttgaaag tgttggaatt gttgagactt aagctaacag cagtaagagc ctgcttacac
     3061 agtcctggtt ctccccaact agatattgaa gaccaagtgg agcctgacca gggttgcatg
     3121 cagagcactt gttttggacc ttccagacta ggaggcattt actgcctcac tttcactagc
     3181 tagccacagg aagagtgttc tccatcctcc tagaggttga acttgacctt cgtgactagt
     3241 gcagttctag cttctctctt gagtcacagt agcatcctga tgccaggagt taggcttttg
     3301 tccagattaa aacaacgagg aaaaggaaat gccccagttt tctttccgtt tcccatttct
     3361 tctttgtcga ttcggtccct gggagactgt ttctccgcgc tgaactgctt tatggtgcat
     3421 ggaatctcca tcagcgtact tctaccctag ccactcacac tccttagaag ctgattttta
     3481 aagcagaagc aaggaagcaa aagtaaaaca ctcccttccc ctctttttcc tcatttcacc
     3541 ttttggtgtt gattgctaat cactttagat atattgttgc tagtgaatgt atgatagatg
     3601 ggttgaagct tttctgataa ttagcacatg atttaaaaca atatatattt aaaacaaata
     3661 tatacagtac atgtattgag ccgtgttaac ctgccaatga gatctgtgaa aaacgtaatg
     3721 gcctcacttt tccctttgaa tttcttttac ctttctgtga agcagctctg cgtggcatac
     3781 atgtatttaa aaacacaaat agtggtagaa tgggtttttt ttttacactt ttaacttagc
     3841 atgtggtgtt gaagtattac catagatcca gtttgtcttc tgcactaaga tgtgaggaaa
     3901 tcgtgatttg ttctctccag cacagtggaa ttacaccttc atcatcttct attgttttga
     3961 aaacactgca gtttaccatg ggacactgta tataattctt gccgtaatgg taaatgacaa
     4021 attgatatat ttaagagtta ataaatttgt gatttctgct ga
//
LOCUS       NM_001437847            3816 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 1, mRNA.
ACCESSION   NM_001437847 XM_008770486
VERSION     NM_001437847.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3816)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3816)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3816)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3816)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3816)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3816)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3816)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3816)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3816)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770486.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.56231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1155           JAXUCZ010000015.1  3598315-3598347
            1156-1224           JAXUCZ010000015.1  3600390-3600458
            1225-1269           JAXUCZ010000015.1  3601575-3601619
            1270-1318           JAXUCZ010000015.1  3604223-3604271
            1319-1432           JAXUCZ010000015.1  3605519-3605632
            1433-1508           JAXUCZ010000015.1  3607566-3607641
            1509-1603           JAXUCZ010000015.1  3607997-3608091
            1604-1848           JAXUCZ010000015.1  3609598-3609842
            1849-3816           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3816
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1836
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 1"
                     /protein_id="NP_001424776.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVV
                     HNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSLVPEGRSPRDRTAPSAGMQPQPSL
                     CSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFY
                     FENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWH
                     RRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1435..1818
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1435..1818
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1155
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1269
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1318
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1432
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1508
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1603
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1848
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..3816
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca agaaaaggaa gtcgagttcc
     1141 agcgtgcacc taatgccaca gagcaacaac aaaaacagtc tcgtaagccc agcccaagag
     1201 cccgcgccct tgcagacggc catggagcca caaaccaccg tggtacataa tgctacagat
     1261 gggatcaagg gctccacaga gagctgcaac accaccacag aagacgaaga tctcaaagct
     1321 gccccgctcc gcactgggaa tggcagcttg gtgcctgaag gacggagccc ccgggacaga
     1381 acagccccct ctgcaggcat gcagccccag ccttctctct gctcctcagc catgcgaaaa
     1441 caggagatca ttaagatcac agaacagctg atagaagcca tcaacaatgg ggactttgag
     1501 gcctacacga agatttgtga cccaggcctc acttcctttg agccagaagc ccttggtaac
     1561 ctcgtggagg ggatggattt ccataagttt tactttgaga atctcctgtc caagaacagc
     1621 aagcctatcc acaccaccat cctaaaccca catgtccatg tcatcggcga ggacgcagct
     1681 tgcatcgcct acatccggct cacccagtac atcgatgggc agggtcggcc tcgcaccagt
     1741 cagtcagagg agacccgggt gtggcaccgc cgggatggca agtggctcaa tgtccactat
     1801 cactgctcag gagcccctgc tgcaccgctg cagtgagctc aggcacaggg gcattaggag
     1861 attccagctg gaggctgaac cttcgaagtc agtgactctg gagggcctga gtgacagccg
     1921 cggtcctgtc catttgaggt ttaaaacaat tacattacaa agcggcagca gccaatgcac
     1981 gcccctgcat gcagccctcc cgcccgccct tcgtgtctgt ctctgctgta ctgaggtgtt
     2041 ttttacattt aagaaaaaaa aaagaaaata agattgtttt aaaaaaaaat ggaattcata
     2101 ccatgatgcg ttttaaaaca actgatagcc tttgggcttg aagaaggcag gagtttgtat
     2161 gatgctcatc caggcgtgaa cagagggctc acccactggc tttgaagagg tgagcttggc
     2221 ctcaggcccc catggactcg ggggggacca ggcaaggact cttgacagag ctttggtcat
     2281 ggacagagcc atgctgtggt tgcagccccg gtggtgacct gatcactcca ggtctaggag
     2341 tggacttctt cagaatatac attgacacct agtatgagaa agaagaaaac tccatggcta
     2401 acagacctac ttgggagaga acgcagcgct cccagcccgc tgtggaggca actgtgaagc
     2461 gtggcctcgg gactgaaggc ctggactttg ccgtaccgtt ccagttagtg tagacaggaa
     2521 gagaattggt gctgcagaag tgtgtccgac acagagccgg tgtgaaacct cgcgttagtc
     2581 tgacacgcac ttactcatcc atttctatag gatgcacaat gcacgtgggc ctgagactga
     2641 ggcctgattt ctgcaggcga gaagggggtg ggattgctac tttgtttcct gttggttttc
     2701 ctaatgtatc aaggagagat ccagacatcg ttggccaggg ctcctgttgc cactttctgc
     2761 agttgtgttt gtgtgcggat ctggaccact ttgtcttata ttttcgtggc ggtggtcccc
     2821 atgccgaccc tctgccaagt gcccctgcgg gatgggagga gtgagataag agttggtggt
     2881 tgtttctatg cattctggct gccctctggg ctgcctccct tcttcccgtg ctgcacgtcc
     2941 gtctctttcc ctgagtttga gattgaaccg actgcttggg tgagaagtgt cctctttaat
     3001 gaggctctct accgaccaac tgaagtatag acttttctgc tggacaatct gcatgggcat
     3061 caccccctca cctgcatgta cccaaaaagg ggtccagagc caaggctcct gtagtcattg
     3121 tccctctctg tgctcaagga gttcctttcc aggaggaaaa gatctgtacc ttaggcagat
     3181 aacagagaag acaatggagg agcaattggt catagtcttg gttccctccc acccaacagc
     3241 tgcacactat ctgcattttg ggggggaagg tgggttgact tcagctcttt ggatgacctt
     3301 cagggaggca caggagctgg gaaaagatac agaactacag actttggaac cagctgagaa
     3361 gagaacaaac tcatgggtgc tggtgcttga atttagccag gctcctcaag caccttgtgc
     3421 atgcctcaga ccctggaccc tagccccttc ctgccctgca gcctgcagtg ccagccaaca
     3481 gatcccttca ccacagggtt tggttttgct ggcttgaaga caacaaatgg tcttagagct
     3541 cattgagacc catagcttca tatggctgct ccagccccac ttagcgttct tactccactt
     3601 ctggggctaa tgtcagcatc tatagacaat taatagacta tttaaaaaaa aaaaccacct
     3661 tttaaacagg aaatgaaagg catttgatgc agaacttttg catgacgaca tagaaataat
     3721 ttaaaaatag tgtttgttct gaatgttggt agtcccttca tagctttgtt acaatgaaac
     3781 cttgaagata tttaataaaa taacctttaa acagtc
//
LOCUS       NM_001012066            2963 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            1, mRNA.
ACCESSION   NM_001012066 XM_218558
VERSION     NM_001012066.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2963)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2963)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2963)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2963)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001012066.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079120.1, SRR26643429.1931.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               JAXUCZ010000001.1  105321608-105322211 c
            605-1076            JAXUCZ010000001.1  105320341-105320812 c
            1077-1226           JAXUCZ010000001.1  105319532-105319681 c
            1227-1321           JAXUCZ010000001.1  105319331-105319425 c
            1322-1437           JAXUCZ010000001.1  105319133-105319248 c
            1438-2963           JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2963
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..604
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1076
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    656..658
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             671..2521
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001012066.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <1124..2491
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <1124..2491
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            1077..1226
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1321
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1437
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2963
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagtgcag actctggagg ggctgccggg acgtcgcagc gtgcacgcag gttgtggggt
       61 ttggggtgac cccagagggg cggacactca ggcccagtgt ggaatactgg gtgaaatctg
      121 gaaactgcaa ccaggtccgg ccctgggata gagactcaga cctggtgttg cgttgcagcc
      181 ctggagtggg ttgtacaggc tagggatacg gggacaaacg gtgctcggtc cgcaacctgt
      241 gggtggagcc aagatctggg gccttgggag tccgagaccc agactaagat ggagcattta
      301 taaggctctg tgttgtctga tttgagggcc tcatacgggt ccctacagct tttaagggtg
      361 gggcagatac atgggcgtta aaggagcggc caagagcagc gggcagaggt agctcctgag
      421 ggacagtatt catgggggcg tgtcccaggc tgctgtgggc ctgggaaagg tgacaaacta
      481 gtcaggcgac tgggttgaac tgccaaaggt gagcaattag gaggttggaa cctttcgctg
      541 agcgggagaa ggggctcagt cctggctcac cttcttcctg gagagaactt ggccagacac
      601 ccagaggctg gaccaggagc tgaccacaag ccaagagtct agaagtgctt gggactgaac
      661 caaggtcgtc atggccccac caccactact gccagtggct gccagcactc cgatcctgca
      721 cggcgagttt ggttcctacc cagcccatgg ccccaggttt gccctcaccc tcacgacaca
      781 agccctacac atacagcgac tgcgcccaaa gccagaagcc cggccccgag atggtctagt
      841 ccctctggac gaggtctcag gctgtggcac tctgcagagc cgtagccccg aagacactgc
      901 agcctacttc tgcatctaca cctacccacg tggccggcgt gggggccggc gcagagctac
      961 tcgtaccttc cgggccgacg gggccgccac ttatgtggag aatcgtgcag aggcccagcg
     1021 ttgggcaact gctctcatgt gtctcctccg aggagtgcct ctgtctgggg accaggaaat
     1081 cacccctgaa ttgctgcccc ggaagcccag gctgctccta ttggtcaatc cttttggggg
     1141 gcggggcctg gcctggcagc gctgtatgga ccacgtggtg cccatgatct ctgaagctgg
     1201 gctgtccttc aacctcatac agacagaacg acaaaaccat gcacgtgagc tggtgcaggg
     1261 gttgagcctg agtgagtggg aaggcattgt cactgtgtcc ggagatgggc tgctttatga
     1321 ggtgctgaat gggctcctcg accgcccaga ttgggaagac gctgtgcgga tgcccattgg
     1381 tgtcctcccc tgtggttcgg gcaatgcact agctggggca gttaaccatc atggcgggtt
     1441 tgagcaaact gttggtgttg acctgttgct caactgctcg cttcttctct gccggggtgg
     1501 cagccatcct ctggacctgc tctctgtgac gctagcctca ggatcccgct gtttttcctt
     1561 cctgtcagtt gcctggggat tcttgtcaga tgtggacatt cacagcgagc gcttcagagc
     1621 cctgggcagt gctcgattca cactgggtgc agtgctaggc ctggccacat tgcataccta
     1681 ccgtggacgt ctctcctacc tccctgctac cacagaacca gccttgccca tcccaggcca
     1741 tggtctgcca agagccaagt cagaactagc cttggcccca gccccagccc cagccgccac
     1801 ccactcacct cttcatcgat ctgtgtctga cctgcccctg cctcttcccc agcctgccct
     1861 ggcctcccct ggctcccctg agcccctgcc tgacctgtcc ctcaatggtg gtggtccaga
     1921 gctgactgga gactgggggg gagctgggga tgcacctttg tccccagacc cattgctgcc
     1981 ttcatccccc aacgctttca aaacagctca gctttcaccc atcgccgaag ggccctcaga
     2041 aatgccagca tcagggctgc tgcctcccat ccacaatgct ccagaagcct ctacctgggg
     2101 cccagcggac cacctgctcc ctcccctggg ctctccactg ccccaagact gggtgacaat
     2161 agagggggag tttgtactca tgttggccat cttgccaagc cacctctgcg cagacctgat
     2221 ggcagcccca cacgcgcgtt ttgacgatgg tgtggtgcac ctgtgctggg tgcggagcgg
     2281 catctcacgg gccgcacttc tacgaatttt gctggccatg gaacatggaa accacttcag
     2341 cctgggctgc ccacatctgg gctatgctgc agcacgtgcc ttccgccttg agccactcac
     2401 gcctcgtggg gtgctcactg tagatgggga attagtagag tatgggccaa tacaggcaca
     2461 ggtgcatcca agtctcgcca cactgctcac tgggcctgca ggtcaaaagc ctcgagcctg
     2521 aatgagccca aagcatgcca agttgatggg accagagccc cataggctaa ggtctacctt
     2581 ttataggtag aagtggggcc tgaactcaga actgcaaggg tagagagtgc tccagaccct
     2641 cagttcccag aggaccctag aggctcgagg gtgggatctg cctttcttga tgtccaatga
     2701 tggggcctgg aatgtatgag ctagcaaggc ttcttcagct tactgtccag tcagggtttc
     2761 ttcttgccta tttcggtgcc tctacttgac tggccaatca gcccttgagg ggcaggttcc
     2821 cccaggtggt ccctagattt gcactaatgt tcccctggcc agttaggggt gggatgttct
     2881 gtgtcttgtg tgtccctgtc cctagtctaa aaagcaattg aaaaggtcta tgcaataaag
     2941 gtgttgcttt ctctggacct gca
//
LOCUS       NM_001437836            4151 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 5, mRNA.
ACCESSION   NM_001437836 XM_017590610
VERSION     NM_001437836.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017590610.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1535975.1,
                                           SRR21887623.3142198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1509           JAXUCZ010000002.1  217916935-217916983
            1510-1585           JAXUCZ010000002.1  217946550-217946625
            1586-1680           JAXUCZ010000002.1  217955065-217955159
            1681-1909           JAXUCZ010000002.1  217957098-217957326
            1910-1998           JAXUCZ010000002.1  217958485-217958573
            1999-4151           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4151
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1976
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 5 is encoded by transcript variant 5;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 5"
                     /protein_id="NP_001424765.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKI
                     CDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIA
                     YIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIKPPCIPNGKEN
                     FSGGTSLWQNI"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1512..1895
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1509
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1585
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1680
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1909
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1998
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..4151
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagtcaactg agagctcaaa taccaccatt gaggatgaag
     1501 acgtgaaagc acgaaagcaa gagatcatca aagtcactga gcagctgatt gaagctatca
     1561 acaatgggga cttcgaggct tacacgaaaa tctgtgatcc aggcctcact gcctttgaac
     1621 ccgaagcatt gggcaactta gtggaaggga tggactttca cagattctac tttgaaaatg
     1681 ctttgcccaa aatcaataaa ccaatccaca ctatcatcct gaaccctcac gtacacctgg
     1741 taggggatga tgcagcctgc atagcataca ttcggctcac acagtacatg gatggaaatg
     1801 gaatgccaaa gacaatgcag tcagaagaga ctcgagtgtg gcaccgccgt gatgggaagt
     1861 ggcagaatat tcactttcat cgttcggggt ccccaacagt ccccatcaag ccaccctgta
     1921 ttccaaatgg gaaagaaaac ttctcaggag gcacctcttt gtggcaaaac atctgaaaac
     1981 cattcacatt tgggtcttct aattgtcaac agtgccacgt cttcattctg tcctcaaggc
     2041 acctggcggg gtgatcctgg gacatcctct cctcttcatg catgtttctg agtgcatgaa
     2101 gttgtgaagg ttctacgtgt aatgcatatg tgacacgtca tcttaccatg tgacacgcca
     2161 tcttaccatg tattccttcc tgtacattgt ttacactcca gctactggac ggatgttcca
     2221 tgcaaacgtc agttactgct ggcaaactaa agagggagct ccgacaagaa aactccgcaa
     2281 tactccaagt tcagctgatc catcaggttt ctctgtggat gccaagattc aaaagacttc
     2341 ataaaattac tgttcaatga atgacagtgt gtaagaggaa aggaaatctt tcaagaatgc
     2401 tgccattaat ctatttgggc ttctcattgg gattttgggg ttgatttttt tttcattttt
     2461 taaggcaaat atatatatat atatatatat atatatatat atatatatat atatatatat
     2521 gccttcagtt cctggtagaa atgaatggat gccttttctc tgaaagtgtt ggtgttggat
     2581 aaatggatgg ctatgtgagc caagtcctgg gtgattgtag gagcaagaat cgtttgctgt
     2641 tctaccatca aagccatgtt gatttgggtc gagctctgta tactggaaaa attcacatca
     2701 ttttctagtt tgattgcttt cagataggca cagttctggt gaatgcttgg cactgatctt
     2761 ggtttttctt tcctaaatct gtgttctgtt ttcattatat actatttgct cctttccttt
     2821 gtatttgttt tcttttccca ctcttttctt tatctttctc tctcccactt tctttctttt
     2881 ttatgttttc ctttctatag ctgatagtgt gtaaaaacag taacatttgc atatgaagtt
     2941 aaaataaaaa tcaaggtctt ctagaagcta aaactagcac ttccggtctc tcacggggct
     3001 gtggagttgt tagaagattt aaataaatac ttaaataaga gaggaatgaa ttcagcttag
     3061 gttaccactt gtgcataggt atccttgctc tgttgaaagt gttggaattg ttgagactta
     3121 agctaacagc agtaagagcc tgcttacaca gtcctggttc tccccaacta gatattgaag
     3181 accaagtgga gcctgaccag ggttgcatgc agagcacttg ttttggacct tccagactag
     3241 gaggcattta ctgcctcact ttcactagct agccacagga agagtgttct ccatcctcct
     3301 agaggttgaa cttgaccttc gtgactagtg cagttctagc ttctctcttg agtcacagta
     3361 gcatcctgat gccaggagtt aggcttttgt ccagattaaa acaacgagga aaaggaaatg
     3421 ccccagtttt ctttccgttt cccatttctt ctttgtcgat tcggtccctg ggagactgtt
     3481 tctccgcgct gaactgcttt atggtgcatg gaatctccat cagcgtactt ctaccctagc
     3541 cactcacact ccttagaagc tgatttttaa agcagaagca aggaagcaaa agtaaaacac
     3601 tcccttcccc tctttttcct catttcacct tttggtgttg attgctaatc actttagata
     3661 tattgttgct agtgaatgta tgatagatgg gttgaagctt ttctgataat tagcacatga
     3721 tttaaaacaa tatatattta aaacaaatat atacagtaca tgtattgagc cgtgttaacc
     3781 tgccaatgag atctgtgaaa aacgtaatgg cctcactttt ccctttgaat ttcttttacc
     3841 tttctgtgaa gcagctctgc gtggcataca tgtatttaaa aacacaaata gtggtagaat
     3901 gggttttttt tttacacttt taacttagca tgtggtgttg aagtattacc atagatccag
     3961 tttgtcttct gcactaagat gtgaggaaat cgtgatttgt tctctccagc acagtggaat
     4021 tacaccttca tcatcttcta ttgttttgaa aacactgcag tttaccatgg gacactgtat
     4081 ataattcttg ccgtaatggt aaatgacaaa ttgatatatt taagagttaa taaatttgtg
     4141 atttctgctg a
//
LOCUS       NM_001047913            1614 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sulfide quinone oxidoreductase (Sqor), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001047913 XM_001077275 XM_001077299 XM_001077317 XM_001077335
            XM_342606
VERSION     NM_001047913.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Augustyn,K.D., Jackson,M.R. and Jorns,M.S.
  TITLE     Use of Tissue Metabolite Analysis and Enzyme Kinetics To
            Discriminate between Alternate Pathways for Hydrogen Sulfide
            Metabolism
  JOURNAL   Biochemistry 56 (7), 986-996 (2017)
   PUBMED   28107627
  REMARK    GeneRIF: The role of Sqor in hydrogen sulfide metabolism in the
            heart and liver
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Ackermann,M., Kubitza,M., Hauska,G. and Pina,A.L.
  TITLE     The vertebrate homologue of sulfide-quinone reductase in mammalian
            mitochondria
  JOURNAL   Cell Tissue Res 358 (3), 779-792 (2014)
   PUBMED   25130143
  REMARK    GeneRIF: The present report demonstrates the presence and specific
            localization of SQRDL in various mammalian tissues.
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Jackson,M.R., Melideo,S.L. and Jorns,M.S.
  TITLE     Human sulfide:quinone oxidoreductase catalyzes the first step in
            hydrogen sulfide metabolism and produces a sulfane sulfur
            metabolite
  JOURNAL   Biochemistry 51 (34), 6804-6815 (2012)
   PUBMED   22852582
REFERENCE   5  (bases 1 to 1614)
  AUTHORS   Ackermann,M., Kubitza,M., Maier,K., Brawanski,A., Hauska,G. and
            Pina,A.L.
  TITLE     The vertebrate homolog of sulfide-quinone reductase is expressed in
            mitochondria of neuronal tissues
  JOURNAL   Neuroscience 199, 1-12 (2011)
   PUBMED   22067608
  REMARK    GeneRIF: we demonstrated that the SQRDL protein is expressed in
            neurons, oligodendrocytes, and endothelial cells
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 1614)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1614)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001047913.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158559.1, SRR26643293.18541.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000003.1  130300216-130300248
            34-284              JAXUCZ010000003.1  130318361-130318611
            285-455             JAXUCZ010000003.1  130320797-130320967
            456-509             JAXUCZ010000003.1  130325592-130325645
            510-704             JAXUCZ010000003.1  130330300-130330494
            705-914             JAXUCZ010000003.1  130331246-130331455
            915-1098            JAXUCZ010000003.1  130335284-130335467
            1099-1166           JAXUCZ010000003.1  130337368-130337435
            1167-1345           JAXUCZ010000003.1  130337681-130337859
            1346-1614           JAXUCZ010000003.1  130339006-130339274
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1614
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="sulfide quinone oxidoreductase"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
     exon            1..33
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            34..284
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="upstream in-frame stop codon"
     CDS             51..1403
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /EC_number="1.8.5.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfide:quinone oxidoreductase, mitochondrial"
                     /codon_start=1
                     /product="sulfide:quinone oxidoreductase, mitochondrial
                     isoform 1"
                     /protein_id="NP_001041378.2"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
                     /translation="MAPLVAVVSSPRARLFACFLRLGTQQAGPLQLHTGACCTAKNHY
                     EVLVLGGGSGGITMATRMKRRVGAENVAIVEPSERHFYQPIWTLVGAGAKELSSSDRS
                     TLSVIPSGVQWIQDRVAELNPDQNCIRTDNGKEISYRYLIIALGIQLDYEKIKGLPEG
                     FAYPKIGSNYSVKTVEKTWKALQDFKEGNALFTFPNTPVKCAGAPQKIMYLSEAYFRK
                     TGKRSKANIIFNTALGTIFGVKKYADALQEIIRERNVSVNYKHNLIEVRADKQEAVFE
                     NLDKPGETHVIHYEMLHVTPPMSSPDVLKRSPVADSAGWVDVDKETLQHKKYPNVFGI
                     GDCTNLPTSKTAAAVAAQSGILDRTISLIMKNQTPTKKYDGYTSCPLVTGYNRVILAE
                     FDYTAQPLETFPFDQSKERISMYLMKADMMPFLYWNMMLRGYWGGPAFLRKLFHLGLS
                     "
     misc_feature    261..1217
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     misc_feature    261..1217
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     exon            285..455
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            456..509
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            510..704
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            705..914
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1098
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1166
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1345
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1614
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaagctg aaatccaagc catggcacaa cagcctgatc taccctggtg atggccccac
       61 tggttgctgt tgtatccagt ccacgtgccc ggctctttgc ttgtttcctt aggctgggca
      121 ctcagcaggc tggacccctc caattgcata cgggagcctg ctgcacagcc aagaaccact
      181 atgaggtgct ggtacttggt gggggaagtg gtgggatcac catggccact cgcatgaaga
      241 ggagagttgg agcggagaat gtggccattg ttgaacccag tgagaggcat ttctaccagc
      301 caatctggac actagtgggt gctggtgcca aagagctgtc ctcatcggac cgttctacac
      361 tgagtgtgat tccatccggt gtgcagtgga ttcaagatag agtggcggaa ctgaacccag
      421 atcagaactg tatccgcaca gacaatggca aggagatctc ctacagatat cttatcatcg
      481 ctcttggaat ccagctggac tatgagaaga ttaaaggact acctgaaggc tttgcttatc
      541 caaaaatagg gtccaattac tcagttaaga cagtggagaa gacatggaag gccctgcagg
      601 acttcaagga aggcaatgcc cttttcacct tcccaaacac tccagtgaag tgtgctggtg
      661 ccccccagaa gatcatgtac ctatcggaag cctacttcag aaagactgga aagcgatcca
      721 aggctaatat catcttcaac acagcccttg gaacaatttt tggagttaag aagtacgcag
      781 atgctttgca ggagatcatt cgggagagga acgtttctgt caactataag cacaatctta
      841 ttgaggtccg agctgacaaa caggaggctg tttttgagaa cctggacaag cctggggaga
      901 cacatgtgat tcattatgaa atgcttcacg tcacgccacc catgagctcg ccagatgtcc
      961 tcaagaggag tcctgtggcc gattctgctg gctgggtgga cgtggataag gagactctgc
     1021 agcataagaa atacccgaat gtgtttggca tcggggactg caccaacctc ccaacttcaa
     1081 agacggctgc tgcagtagct gcccaatctg gaatccttga tagaacaatt tctctgatta
     1141 tgaagaatca aacacccaca aaaaagtatg atggctatac ctcgtgccca ctggtgactg
     1201 gttacaaccg tgtgattctt gctgagtttg actacacagc tcagcctctg gaaaccttcc
     1261 cctttgatca gagtaaagaa cgaatttcca tgtacctcat gaaggctgac atgatgccgt
     1321 tcctgtattg gaatatgatg ctaagaggct actggggagg tccagccttc ttgcgaaagc
     1381 tgtttcatct gggcctgagt taaagatggc tcagcacttg ctctttttgg atgatgtctg
     1441 gaccaaaatc acagttactg attgacatga cagatccaaa ggactcagaa tcttaccctt
     1501 taaggagttt cttactggac atgatgacct ttctagacct ctgaatagct atcatgtgaa
     1561 caacccagaa tgagtctttg gaaacatcca aaataaaatt ctattttata aata
//
LOCUS       NM_001437861            3715 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 12, mRNA.
ACCESSION   NM_001437861 XM_063273937
VERSION     NM_001437861.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3715)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3715)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3715)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3715)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3715)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3715)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3715)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3715)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3715)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063273937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1944582.1,
                                           SRR26360194.792732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000015.1  3556246-3556469
            225-284             JAXUCZ010000015.1  3568253-3568312
            285-339             JAXUCZ010000015.1  3576050-3576104
            340-405             JAXUCZ010000015.1  3576930-3576995
            406-478             JAXUCZ010000015.1  3580329-3580401
            479-581             JAXUCZ010000015.1  3580559-3580661
            582-665             JAXUCZ010000015.1  3581097-3581180
            666-760             JAXUCZ010000015.1  3581604-3581698
            761-883             JAXUCZ010000015.1  3582328-3582450
            884-967             JAXUCZ010000015.1  3586196-3586279
            968-1010            JAXUCZ010000015.1  3586516-3586558
            1011-1054           JAXUCZ010000015.1  3590901-3590944
            1055-1123           JAXUCZ010000015.1  3600390-3600458
            1124-1168           JAXUCZ010000015.1  3601575-3601619
            1169-1217           JAXUCZ010000015.1  3604223-3604271
            1218-1331           JAXUCZ010000015.1  3605519-3605632
            1332-1407           JAXUCZ010000015.1  3607566-3607641
            1408-1502           JAXUCZ010000015.1  3607997-3608091
            1503-1747           JAXUCZ010000015.1  3609598-3609842
            1748-3715           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3715
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    179..181
                     /gene="Camk2g"
                     /note="upstream in-frame stop codon"
     CDS             185..1735
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 12 is encoded by transcript variant 12;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 12"
                     /protein_id="NP_001424790.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MHRKLNAEGWGPEDHQKLEREARICRLLKHPNIVRLHDSISEEG
                     FHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENL
                     LLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC
                     GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPA
                     KRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSA
                     AKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESC
                     NTTTEDEDLKAAPLRTGNGSLVPEGRSPRDRTAPSAGMQPQPSLCSSAMRKQEIIKIT
                     EQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHT
                     TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCS
                     GAPAAPLQ"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1334..1717
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1334..1717
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            225..284
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            285..339
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            340..405
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            406..478
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            479..581
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            666..760
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            761..883
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            884..967
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1010
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1054
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1123
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1168
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1217
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1331
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1407
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1502
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1747
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..3715
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagacatg ctctgactaa gaatggaaga ggcaggcagg aatgaggtga agatgggtct
       61 ctccctgtgc ccacacagcc tagccctggt gtagcagaaa tgtggctgac atctggtgtc
      121 tccagcggat ggtgcagctc cttgctttgc tcctcatcag tgcctactgg tccaggagtg
      181 agaaatgcat aggaagctga acgctgaagg ctggggacct gaagatcatc agaaactaga
      241 acgagaggcc cggatatgcc gacttctgaa acatccaaac atcgtgcgtc tccatgacag
      301 tatttctgaa gaagggtttc actacctcgt gtttgacctt gttacgggag gggagttgtt
      361 tgaagacatc gtggccagag aatactacag cgaagctgat gccagccact gtatacatca
      421 gatcctggag agcgtcaacc acatccacca gcatgacatc gtccaccggg acctgaagcc
      481 cgagaacttg ctgctggcga gtaaatgcaa gggtgctgcg gtcaagctag ctgattttgg
      541 cctggccatc gaagtgcagg gagagcagca ggcttggttt ggttttgctg gcaccccagg
      601 ttacttgtcc cctgaggtct tgaggaaaga tccctatgga aaacctgtgg atatctgggc
      661 ctgcggggtc atcctgtata tcctcctggt gggctaccct cccttctggg atgaggatca
      721 gcacaagctc tatcagcaga tcaaagctgg agcctacgat ttcccatcac cagaatggga
      781 cacagtcact cctgaagcta agaacttgat caaccagatg ttgaccataa accctgcaaa
      841 gcgtatcaca gctgaccagg ctctcaagca cccatgggtc tgtcaacggt caacagtggc
      901 atccatgatg catcgccaag agacagtgga gtgcttacgc aagttcaacg cccggagaaa
      961 actgaagggt gccatcctca caaccatgct tgtctccagg aacttttcag ctgccaagag
     1021 cctattgaac aagaagtcag atggcggcgt caagccacag agcaacaaca aaaacagtct
     1081 cgtaagccca gcccaagagc ccgcgccctt gcagacggcc atggagccac aaaccaccgt
     1141 ggtacataat gctacagatg ggatcaaggg ctccacagag agctgcaaca ccaccacaga
     1201 agacgaagat ctcaaagctg ccccgctccg cactgggaat ggcagcttgg tgcctgaagg
     1261 acggagcccc cgggacagaa cagccccctc tgcaggcatg cagccccagc cttctctctg
     1321 ctcctcagcc atgcgaaaac aggagatcat taagatcaca gaacagctga tagaagccat
     1381 caacaatggg gactttgagg cctacacgaa gatttgtgac ccaggcctca cttcctttga
     1441 gccagaagcc cttggtaacc tcgtggaggg gatggatttc cataagtttt actttgagaa
     1501 tctcctgtcc aagaacagca agcctatcca caccaccatc ctaaacccac atgtccatgt
     1561 catcggcgag gacgcagctt gcatcgccta catccggctc acccagtaca tcgatgggca
     1621 gggtcggcct cgcaccagtc agtcagagga gacccgggtg tggcaccgcc gggatggcaa
     1681 gtggctcaat gtccactatc actgctcagg agcccctgct gcaccgctgc agtgagctca
     1741 ggcacagggg cattaggaga ttccagctgg aggctgaacc ttcgaagtca gtgactctgg
     1801 agggcctgag tgacagccgc ggtcctgtcc atttgaggtt taaaacaatt acattacaaa
     1861 gcggcagcag ccaatgcacg cccctgcatg cagccctccc gcccgccctt cgtgtctgtc
     1921 tctgctgtac tgaggtgttt tttacattta agaaaaaaaa aagaaaataa gattgtttta
     1981 aaaaaaaatg gaattcatac catgatgcgt tttaaaacaa ctgatagcct ttgggcttga
     2041 agaaggcagg agtttgtatg atgctcatcc aggcgtgaac agagggctca cccactggct
     2101 ttgaagaggt gagcttggcc tcaggccccc atggactcgg gggggaccag gcaaggactc
     2161 ttgacagagc tttggtcatg gacagagcca tgctgtggtt gcagccccgg tggtgacctg
     2221 atcactccag gtctaggagt ggacttcttc agaatataca ttgacaccta gtatgagaaa
     2281 gaagaaaact ccatggctaa cagacctact tgggagagaa cgcagcgctc ccagcccgct
     2341 gtggaggcaa ctgtgaagcg tggcctcggg actgaaggcc tggactttgc cgtaccgttc
     2401 cagttagtgt agacaggaag agaattggtg ctgcagaagt gtgtccgaca cagagccggt
     2461 gtgaaacctc gcgttagtct gacacgcact tactcatcca tttctatagg atgcacaatg
     2521 cacgtgggcc tgagactgag gcctgatttc tgcaggcgag aagggggtgg gattgctact
     2581 ttgtttcctg ttggttttcc taatgtatca aggagagatc cagacatcgt tggccagggc
     2641 tcctgttgcc actttctgca gttgtgtttg tgtgcggatc tggaccactt tgtcttatat
     2701 tttcgtggcg gtggtcccca tgccgaccct ctgccaagtg cccctgcggg atgggaggag
     2761 tgagataaga gttggtggtt gtttctatgc attctggctg ccctctgggc tgcctccctt
     2821 cttcccgtgc tgcacgtccg tctctttccc tgagtttgag attgaaccga ctgcttgggt
     2881 gagaagtgtc ctctttaatg aggctctcta ccgaccaact gaagtataga cttttctgct
     2941 ggacaatctg catgggcatc accccctcac ctgcatgtac ccaaaaaggg gtccagagcc
     3001 aaggctcctg tagtcattgt ccctctctgt gctcaaggag ttcctttcca ggaggaaaag
     3061 atctgtacct taggcagata acagagaaga caatggagga gcaattggtc atagtcttgg
     3121 ttccctccca cccaacagct gcacactatc tgcattttgg gggggaaggt gggttgactt
     3181 cagctctttg gatgaccttc agggaggcac aggagctggg aaaagataca gaactacaga
     3241 ctttggaacc agctgagaag agaacaaact catgggtgct ggtgcttgaa tttagccagg
     3301 ctcctcaagc accttgtgca tgcctcagac cctggaccct agccccttcc tgccctgcag
     3361 cctgcagtgc cagccaacag atcccttcac cacagggttt ggttttgctg gcttgaagac
     3421 aacaaatggt cttagagctc attgagaccc atagcttcat atggctgctc cagccccact
     3481 tagcgttctt actccacttc tggggctaat gtcagcatct atagacaatt aatagactat
     3541 ttaaaaaaaa aaaccacctt ttaaacagga aatgaaaggc atttgatgca gaacttttgc
     3601 atgacgacat agaaataatt taaaaatagt gtttgttctg aatgttggta gtcccttcat
     3661 agctttgtta caatgaaacc ttgaagatat ttaataaaat aacctttaaa cagtc
//
LOCUS       NM_001437853            3753 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 3, mRNA.
ACCESSION   NM_001437853 XM_008770489
VERSION     NM_001437853.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3753)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3753)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3753)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3753)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3753)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3753)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3753)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3753)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3753)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3753)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770489.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.63496.1,
                                           SRR26643298.56233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1092           JAXUCZ010000015.1  3598315-3598347
            1093-1161           JAXUCZ010000015.1  3600390-3600458
            1162-1206           JAXUCZ010000015.1  3601575-3601619
            1207-1255           JAXUCZ010000015.1  3604223-3604271
            1256-1369           JAXUCZ010000015.1  3605519-3605632
            1370-1445           JAXUCZ010000015.1  3607566-3607641
            1446-1540           JAXUCZ010000015.1  3607997-3608091
            1541-1785           JAXUCZ010000015.1  3609598-3609842
            1786-3753           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3753
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1773
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 3 is encoded by transcript variant 3;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 3"
                     /protein_id="NP_001424782.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKS
                     SSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDE
                     DLKAAPLRTGNGSLVPEGRSPRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAI
                     NNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV
                     HVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPL
                     Q"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1372..1755
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1372..1755
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1092
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1161
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1206
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1255
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1369
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1445
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1540
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1785
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..3753
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaaga aaaggaagtc gagttccagc
     1081 gtgcacctaa tgccacagag caacaacaaa aacagtctcg taagcccagc ccaagagccc
     1141 gcgcccttgc agacggccat ggagccacaa accaccgtgg tacataatgc tacagatggg
     1201 atcaagggct ccacagagag ctgcaacacc accacagaag acgaagatct caaagctgcc
     1261 ccgctccgca ctgggaatgg cagcttggtg cctgaaggac ggagcccccg ggacagaaca
     1321 gccccctctg caggcatgca gccccagcct tctctctgct cctcagccat gcgaaaacag
     1381 gagatcatta agatcacaga acagctgata gaagccatca acaatgggga ctttgaggcc
     1441 tacacgaaga tttgtgaccc aggcctcact tcctttgagc cagaagccct tggtaacctc
     1501 gtggagggga tggatttcca taagttttac tttgagaatc tcctgtccaa gaacagcaag
     1561 cctatccaca ccaccatcct aaacccacat gtccatgtca tcggcgagga cgcagcttgc
     1621 atcgcctaca tccggctcac ccagtacatc gatgggcagg gtcggcctcg caccagtcag
     1681 tcagaggaga cccgggtgtg gcaccgccgg gatggcaagt ggctcaatgt ccactatcac
     1741 tgctcaggag cccctgctgc accgctgcag tgagctcagg cacaggggca ttaggagatt
     1801 ccagctggag gctgaacctt cgaagtcagt gactctggag ggcctgagtg acagccgcgg
     1861 tcctgtccat ttgaggttta aaacaattac attacaaagc ggcagcagcc aatgcacgcc
     1921 cctgcatgca gccctcccgc ccgcccttcg tgtctgtctc tgctgtactg aggtgttttt
     1981 tacatttaag aaaaaaaaaa gaaaataaga ttgttttaaa aaaaaatgga attcatacca
     2041 tgatgcgttt taaaacaact gatagccttt gggcttgaag aaggcaggag tttgtatgat
     2101 gctcatccag gcgtgaacag agggctcacc cactggcttt gaagaggtga gcttggcctc
     2161 aggcccccat ggactcgggg gggaccaggc aaggactctt gacagagctt tggtcatgga
     2221 cagagccatg ctgtggttgc agccccggtg gtgacctgat cactccaggt ctaggagtgg
     2281 acttcttcag aatatacatt gacacctagt atgagaaaga agaaaactcc atggctaaca
     2341 gacctacttg ggagagaacg cagcgctccc agcccgctgt ggaggcaact gtgaagcgtg
     2401 gcctcgggac tgaaggcctg gactttgccg taccgttcca gttagtgtag acaggaagag
     2461 aattggtgct gcagaagtgt gtccgacaca gagccggtgt gaaacctcgc gttagtctga
     2521 cacgcactta ctcatccatt tctataggat gcacaatgca cgtgggcctg agactgaggc
     2581 ctgatttctg caggcgagaa gggggtggga ttgctacttt gtttcctgtt ggttttccta
     2641 atgtatcaag gagagatcca gacatcgttg gccagggctc ctgttgccac tttctgcagt
     2701 tgtgtttgtg tgcggatctg gaccactttg tcttatattt tcgtggcggt ggtccccatg
     2761 ccgaccctct gccaagtgcc cctgcgggat gggaggagtg agataagagt tggtggttgt
     2821 ttctatgcat tctggctgcc ctctgggctg cctcccttct tcccgtgctg cacgtccgtc
     2881 tctttccctg agtttgagat tgaaccgact gcttgggtga gaagtgtcct ctttaatgag
     2941 gctctctacc gaccaactga agtatagact tttctgctgg acaatctgca tgggcatcac
     3001 cccctcacct gcatgtaccc aaaaaggggt ccagagccaa ggctcctgta gtcattgtcc
     3061 ctctctgtgc tcaaggagtt cctttccagg aggaaaagat ctgtacctta ggcagataac
     3121 agagaagaca atggaggagc aattggtcat agtcttggtt ccctcccacc caacagctgc
     3181 acactatctg cattttgggg gggaaggtgg gttgacttca gctctttgga tgaccttcag
     3241 ggaggcacag gagctgggaa aagatacaga actacagact ttggaaccag ctgagaagag
     3301 aacaaactca tgggtgctgg tgcttgaatt tagccaggct cctcaagcac cttgtgcatg
     3361 cctcagaccc tggaccctag ccccttcctg ccctgcagcc tgcagtgcca gccaacagat
     3421 cccttcacca cagggtttgg ttttgctggc ttgaagacaa caaatggtct tagagctcat
     3481 tgagacccat agcttcatat ggctgctcca gccccactta gcgttcttac tccacttctg
     3541 gggctaatgt cagcatctat agacaattaa tagactattt aaaaaaaaaa accacctttt
     3601 aaacaggaaa tgaaaggcat ttgatgcaga acttttgcat gacgacatag aaataattta
     3661 aaaatagtgt ttgttctgaa tgttggtagt cccttcatag ctttgttaca atgaaacctt
     3721 gaagatattt aataaaataa cctttaaaca gtc
//
LOCUS       NM_033485               2228 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), transcript
            variant 2, mRNA.
ACCESSION   NM_033485 XM_039079857
VERSION     NM_033485.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Hao,Y., Niu,H., An,S., Wang,M. and Wang,Z.
  TITLE     Downregulation of iNOS, IL-1beta, and P2X7 Expression in Mast Cells
            via Activation of PAR4 Contributes to the Inhibition of Visceral
            Hyperalgesia in Rats
  JOURNAL   J Immunol Res 2018, 3256908 (2018)
   PUBMED   29854833
  REMARK    GeneRIF: this study shows that downregulation of iNOS, IL-1beta,
            and P2X7 expression in mast cells via activation of PAR4
            contributes to the Inhibition of visceral hyperalgesia
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Du,W.W., Li,X., Li,T., Li,H., Khorshidi,A., Liu,F. and Yang,B.B.
  TITLE     The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence
            by targeting Par4
  JOURNAL   J Cell Sci 128 (2), 293-304 (2015)
   PUBMED   25472717
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   de Thonel,A., Hazoume,A., Kochin,V., Isoniemi,K., Jego,G.,
            Fourmaux,E., Hammann,A., Mjahed,H., Filhol,O., Micheau,O.,
            Rocchi,P., Mezger,V., Eriksson,J.E., Rangnekar,V.M. and Garrido,C.
  TITLE     Regulation of the proapoptotic functions of prostate apoptosis
            response-4 (Par-4) by casein kinase 2 in prostate cancer cells
  JOURNAL   Cell Death Dis 5 (1), e1016 (2014)
   PUBMED   24457960
  REMARK    GeneRIF: Phosphorylation by CK2 impairs Par-4 proapoptotic
            functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Wang,Z., Chen,D., Zhang,R., An,S., Zhang,Z. and Ma,Q.
  TITLE     Interleukin-1beta increased the expression of protease-activated
            receptor 4 mRNA and protein in dorsal root ganglion neurons
  JOURNAL   Neurochem Res 38 (9), 1895-1903 (2013)
   PUBMED   23775412
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   MacDonald,J.A., Moffat,L.D., Al-Ghabkari,A., Sutherland,C. and
            Walsh,M.P.
  TITLE     Prostate-apoptosis response-4 phosphorylation in vascular smooth
            muscle
  JOURNAL   Arch Biochem Biophys 535 (1), 84-90 (2013)
   PUBMED   23219599
  REMARK    GeneRIF: Par-4 binding does not block MYPT1 phosphorylation in rat
            caudal arterial smooth muscle.
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   Duan,W., Rangnekar,V.M. and Mattson,M.P.
  TITLE     Prostate apoptosis response-4 production in synaptic compartments
            following apoptotic and excitotoxic insults: evidence for a pivotal
            role in mitochondrial dysfunction and neuronal degeneration
  JOURNAL   J Neurochem 72 (6), 2312-2322 (1999)
   PUBMED   10349840
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Boghaert,E.R., Sells,S.F., Walid,A.J., Malone,P., Williams,N.M.,
            Weinstein,M.H., Strange,R. and Rangnekar,V.M.
  TITLE     Immunohistochemical analysis of the proapoptotic protein Par-4 in
            normal rat tissues
  JOURNAL   Cell Growth Differ 8 (8), 881-890 (1997)
   PUBMED   9269897
REFERENCE   9  (bases 1 to 2228)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
REFERENCE   10 (bases 1 to 2228)
  AUTHORS   Sells,S.F., Wood,D.P. Jr., Joshi-Barve,S.S., Muthukumar,S.,
            Jacob,R.J., Crist,S.A., Humphreys,S. and Rangnekar,V.M.
  TITLE     Commonality of the gene programs induced by effectors of apoptosis
            in androgen-dependent and -independent prostate cells
  JOURNAL   Cell Growth Differ 5 (4), 457-466 (1994)
   PUBMED   8043520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 10, 2025 this sequence version replaced
            XM_039079857.2, NM_033485.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.30560.1,
                                           SRR26643291.20200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000007.1  45531648-45531760
            114-672             JAXUCZ010000007.1  45532238-45532796
            673-804             JAXUCZ010000007.1  45582043-45582174
            805-839             JAXUCZ010000007.1  45590321-45590355
            840-987             JAXUCZ010000007.1  45605743-45605890
            988-1092            JAXUCZ010000007.1  45608522-45608626
            1093-2228           JAXUCZ010000007.1  45610357-45611492
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..2228
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="pro-apoptotic WT1 regulator"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
     exon            1..113
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            114..672
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1179
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="prostate apoptosis response 4 protein;
                     transcriptional repressor Par-4-like protein PAWR; par-4
                     induced by effectors of apoptosis; Prostate apoptosis
                     response protein 4; PRKC, apoptosis, WT1, regulator"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein"
                     /protein_id="NP_277020.2"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
                     /translation="MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAA
                     KSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDE
                     CPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNI
                     PAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRY
                     KSTTSAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQ
                     ENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR"
     misc_feature    181..939
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    361..375
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: B30.2/SPRY domain-binding motif.
                     /evidence=ECO:0000250|UniProtKB:Q96IZ0"
     misc_feature    589..765
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Selective for apoptosis induction in cancer cells
                     (SAC)"
     misc_feature    589..639
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Nuclear localization signal"
     misc_feature    643..645
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Phosphothreonine, by PKA.
                     /evidence=ECO:0000269|PubMed:15657440; propagated from
                     UniProtKB/Swiss-Prot (Q62627.1); phosphorylation site"
     misc_feature    847..849
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96IZ0; propagated from
                     UniProtKB/Swiss-Prot (Q62627.1); phosphorylation site"
     misc_feature    952..1155
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; Region: Atg16_CCD; cl46300"
                     /db_xref="CDD:480640"
     misc_feature    952..1155
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; Region: Atg16_CCD; cl46300"
                     /db_xref="CDD:480640"
     misc_feature    order(958..963,967..972,979..981,988..993,1000..1005,
                     1009..1014,1021..1026,1033..1035,1042..1047,1054..1056,
                     1063..1068,1072..1077,1084..1086,1093..1098,1105..1110,
                     1114..1119,1126..1131,1135..1140,1147..1152)
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:439196"
     misc_feature    order(958..963,967..972,979..981,988..993,1000..1005,
                     1009..1014,1021..1026,1033..1035,1042..1047,1054..1056,
                     1063..1068,1072..1077,1084..1086,1093..1098,1105..1110,
                     1114..1119,1126..1131,1135..1140,1147..1152)
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:439196"
     misc_feature    1054..1176
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Leucine-zipper"
     exon            673..804
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..839
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            840..987
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1092
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..2228
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccggcc ggcgagcttg cggctgctgg tcgtccgcgt cgcgggctct ccggctcacc
       61 tggacaaccc tcctccccgc cccgcgcctt gtcccaccga aaagttctcg gaggcaggcg
      121 gcggcggcgg gagtcaggag tcgcggcgtg aggggcgccc ccgccggccc ctctgggaac
      181 atggcgaccg gcggctatcg gagcagcggc agcaccacgg acttcctgga ggagtggaaa
      241 gcgaagcgcg agaagatgcg cgccaagcag aaccccgtgg gcccgggttc gagcggcggg
      301 gatccagccg ccaagtcccc tgcgggaccg ctcgcccaga ctacggccgc ggggacctcg
      361 gaactcaacc acggccccgc cggcgcggcc gcacctgccg cccccgggcc gggcgccctg
      421 aactgcgctc acggctcgtc cgcgctgccc cgcggggctc ccggctcccg gcggccggag
      481 gacgagtgtc ctattgccgc tggggccgcg ggagcacccg cgtcccgggg agacgaggag
      541 gagccggata gcgccccgga gaagggccgc agctcggggc ccagcgccag gaaaggcaaa
      601 gggcagatcg agaagaggaa gctgcgggag aagcgccgct ccaccggcgt ggtcaacatc
      661 cccgcggcgg agtgcttaga tgagtacgaa gatgacgaag caggacagaa ggaacggaag
      721 cgagaggatg ctatcacaca gcagaacacc atccagaatg aagctgcgag cctcccagat
      781 ccaggaacct cctacctgcc ccaggacccg tcgagaacag tcccaggcag atacaaaagc
      841 acaaccagtg ccccagaaga agaaatctta aatagatatc cccgaacaga tagaagtggc
      901 ttcagtagac acaacagaga taccagtgcg cctgctaact tcgcttcaag tagcaccttg
      961 gaaaagagaa ttgaagatct tgagaaggaa gtcttgagag aaaggcaaga aaaccttcga
     1021 cttacgaggc tgatgcaaga taaagaagaa atgattggaa aactcaagga agagattgat
     1081 ttgttaaata gagacctcga tgacatggaa gacgaaaacg agcaactaaa gcaggaaaat
     1141 aaaactcttt tgaaagttgt tgggcagctg acaaggtaga agacgcaagg ctgcctcggt
     1201 gtgggaaacc tgcttttaaa ccgcggatga atgtcatggc gaaggcgccc gtgattcagt
     1261 gcgctgagag aactgtatat ttatttctag aaaacacatg gatctcttct tctcaaaatt
     1321 tactctttct cattactagt ttttaaaaag tgtaaatccc cgtctttcac atagaagtta
     1381 acatctttag ctattaaaat gataggtgat gcctcttggt tctgtgtgat actcagataa
     1441 tatatggttc gaagtagcag ccatttgcat atgttttatc tatgttagca catattctcc
     1501 ctaaaggaag atgcatagtc tttgtttaca tgaattcaaa tccttggggg agttgcctac
     1561 agatgcccta ttactaatgt gtgcgccttc cgtgtgctaa tgcctactca taaagacgca
     1621 tctgccgtct cgtcctccca cgggctctcc tgattccgag tggtaataga tacactactt
     1681 tgtatagcag taatcgttca aaggaaagct attttgcagt tatttcatat gttctagttg
     1741 gctaaatata aacttaagaa aatacttgaa ctgtgttata gtaagtgaaa aattactatt
     1801 ttgtgtttga atattgaaaa aaatttcagt aacttctgaa aaacagttaa tgtatagttt
     1861 cttatgtagg tactatcatt cttttttttt tattgctcta gggtttacta gtaaataatg
     1921 ggatatttaa aaagttgttt attcttcagg cctcaattgt gtacaatttc agtattgaag
     1981 aagaaaattg atgctgtgaa tagcatgtgc ttcaaaaatc agaactaaaa aatttttcca
     2041 cacttaaaat atgtacacat acgtcagcat gtgtaagcag agataacaca gatatctcag
     2101 ccgattcctg agttggagac accctgggat gctttttgtc aatagagaat catcccataa
     2161 ccctaacact gaagatttta aagcaaccat atttgaagat ttataaaata aagttgtctt
     2221 ctattaaa
//
LOCUS       NM_001437827            2493 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            6, mRNA.
ACCESSION   NM_001437827 XM_039112297
VERSION     NM_001437827.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2493)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2493)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2493)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2493)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2493)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2493)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2493)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039112297.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.2168.1,
                                           SRR26643429.1934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000001.1  105322078-105322211 c
            135-606             JAXUCZ010000001.1  105320341-105320812 c
            607-756             JAXUCZ010000001.1  105319532-105319681 c
            757-851             JAXUCZ010000001.1  105319331-105319425 c
            852-967             JAXUCZ010000001.1  105319133-105319248 c
            968-2493            JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2493
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..134
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            135..606
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             201..2051
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424756.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <654..2021
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <654..2021
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            607..756
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..851
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..967
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..2493
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagtgcag actctggagg ggctgccggg acgtcgcagc gtgcacgcag gttgtggggt
       61 ttggggtgac cccagagggg cggacactca ggcccagtgt ggaatactgg gtgaaatctg
      121 gaaactgcaa ccagaggctg gaccaggagc tgaccacaag ccaagagtct agaagtgctt
      181 gggactgaac caaggtcgtc atggccccac caccactact gccagtggct gccagcactc
      241 cgatcctgca cggcgagttt ggttcctacc cagcccatgg ccccaggttt gccctcaccc
      301 tcacgacaca agccctacac atacagcgac tgcgcccaaa gccagaagcc cggccccgag
      361 atggtctagt ccctctggac gaggtctcag gctgtggcac tctgcagagc cgtagccccg
      421 aagacactgc agcctacttc tgcatctaca cctacccacg tggccggcgt gggggccggc
      481 gcagagctac tcgtaccttc cgggccgacg gggccgccac ttatgtggag aatcgtgcag
      541 aggcccagcg ttgggcaact gctctcatgt gtctcctccg aggagtgcct ctgtctgggg
      601 accaggaaat cacccctgaa ttgctgcccc ggaagcccag gctgctccta ttggtcaatc
      661 cttttggggg gcggggcctg gcctggcagc gctgtatgga ccacgtggtg cccatgatct
      721 ctgaagctgg gctgtccttc aacctcatac agacagaacg acaaaaccat gcacgtgagc
      781 tggtgcaggg gttgagcctg agtgagtggg aaggcattgt cactgtgtcc ggagatgggc
      841 tgctttatga ggtgctgaat gggctcctcg accgcccaga ttgggaagac gctgtgcgga
      901 tgcccattgg tgtcctcccc tgtggttcgg gcaatgcact agctggggca gttaaccatc
      961 atggcgggtt tgagcaaact gttggtgttg acctgttgct caactgctcg cttcttctct
     1021 gccggggtgg cagccatcct ctggacctgc tctctgtgac gctagcctca ggatcccgct
     1081 gtttttcctt cctgtcagtt gcctggggat tcttgtcaga tgtggacatt cacagcgagc
     1141 gcttcagagc cctgggcagt gctcgattca cactgggtgc agtgctaggc ctggccacat
     1201 tgcataccta ccgtggacgt ctctcctacc tccctgctac cacagaacca gccttgccca
     1261 tcccaggcca tggtctgcca agagccaagt cagaactagc cttggcccca gccccagccc
     1321 cagccgccac ccactcacct cttcatcgat ctgtgtctga cctgcccctg cctcttcccc
     1381 agcctgccct ggcctcccct ggctcccctg agcccctgcc tgacctgtcc ctcaatggtg
     1441 gtggtccaga gctgactgga gactgggggg gagctgggga tgcacctttg tccccagacc
     1501 cattgctgcc ttcatccccc aacgctttca aaacagctca gctttcaccc atcgccgaag
     1561 ggccctcaga aatgccagca tcagggctgc tgcctcccat ccacaatgct ccagaagcct
     1621 ctacctgggg cccagcggac cacctgctcc ctcccctggg ctctccactg ccccaagact
     1681 gggtgacaat agagggggag tttgtactca tgttggccat cttgccaagc cacctctgcg
     1741 cagacctgat ggcagcccca cacgcgcgtt ttgacgatgg tgtggtgcac ctgtgctggg
     1801 tgcggagcgg catctcacgg gccgcacttc tacgaatttt gctggccatg gaacatggaa
     1861 accacttcag cctgggctgc ccacatctgg gctatgctgc agcacgtgcc ttccgccttg
     1921 agccactcac gcctcgtggg gtgctcactg tagatgggga attagtagag tatgggccaa
     1981 tacaggcaca ggtgcatcca agtctcgcca cactgctcac tgggcctgca ggtcaaaagc
     2041 ctcgagcctg aatgagccca aagcatgcca agttgatggg accagagccc cataggctaa
     2101 ggtctacctt ttataggtag aagtggggcc tgaactcaga actgcaaggg tagagagtgc
     2161 tccagaccct cagttcccag aggaccctag aggctcgagg gtgggatctg cctttcttga
     2221 tgtccaatga tggggcctgg aatgtatgag ctagcaaggc ttcttcagct tactgtccag
     2281 tcagggtttc ttcttgccta tttcggtgcc tctacttgac tggccaatca gcccttgagg
     2341 ggcaggttcc cccaggtggt ccctagattt gcactaatgt tcccctggcc agttaggggt
     2401 gggatgttct gtgtcttgtg tgtccctgtc cctagtctaa aaagcaattg aaaaggtcta
     2461 tgcaataaag gtgttgcttt ctctggacct gca
//
LOCUS       NM_001437860            3606 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 11, mRNA.
ACCESSION   NM_001437860 XM_008770497
VERSION     NM_001437860.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3606)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3606)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3606)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3606)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3606)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3606)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3606)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3606)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770497.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.33853.1,
                                           SRR26643299.56076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1128           JAXUCZ010000015.1  3600390-3600458
            1129-1173           JAXUCZ010000015.1  3601575-3601619
            1174-1222           JAXUCZ010000015.1  3604223-3604271
            1223-1298           JAXUCZ010000015.1  3607566-3607641
            1299-1393           JAXUCZ010000015.1  3607997-3608091
            1394-1638           JAXUCZ010000015.1  3609598-3609842
            1639-3606           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3606
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1626
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 11 is encoded by transcript variant 11;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 11"
                     /protein_id="NP_001424789.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKPQSN
                     NKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIK
                     ITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPI
                     HTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYH
                     CSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1225..1608
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1225..1608
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1128
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1173
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1222
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1298
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1393
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1638
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..3606
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaagc cacagagcaa caacaaaaac
     1081 agtctcgtaa gcccagccca agagcccgcg cccttgcaga cggccatgga gccacaaacc
     1141 accgtggtac ataatgctac agatgggatc aagggctcca cagagagctg caacaccacc
     1201 acagaagacg aagatctcaa agtgcgaaaa caggagatca ttaagatcac agaacagctg
     1261 atagaagcca tcaacaatgg ggactttgag gcctacacga agatttgtga cccaggcctc
     1321 acttcctttg agccagaagc ccttggtaac ctcgtggagg ggatggattt ccataagttt
     1381 tactttgaga atctcctgtc caagaacagc aagcctatcc acaccaccat cctaaaccca
     1441 catgtccatg tcatcggcga ggacgcagct tgcatcgcct acatccggct cacccagtac
     1501 atcgatgggc agggtcggcc tcgcaccagt cagtcagagg agacccgggt gtggcaccgc
     1561 cgggatggca agtggctcaa tgtccactat cactgctcag gagcccctgc tgcaccgctg
     1621 cagtgagctc aggcacaggg gcattaggag attccagctg gaggctgaac cttcgaagtc
     1681 agtgactctg gagggcctga gtgacagccg cggtcctgtc catttgaggt ttaaaacaat
     1741 tacattacaa agcggcagca gccaatgcac gcccctgcat gcagccctcc cgcccgccct
     1801 tcgtgtctgt ctctgctgta ctgaggtgtt ttttacattt aagaaaaaaa aaagaaaata
     1861 agattgtttt aaaaaaaaat ggaattcata ccatgatgcg ttttaaaaca actgatagcc
     1921 tttgggcttg aagaaggcag gagtttgtat gatgctcatc caggcgtgaa cagagggctc
     1981 acccactggc tttgaagagg tgagcttggc ctcaggcccc catggactcg ggggggacca
     2041 ggcaaggact cttgacagag ctttggtcat ggacagagcc atgctgtggt tgcagccccg
     2101 gtggtgacct gatcactcca ggtctaggag tggacttctt cagaatatac attgacacct
     2161 agtatgagaa agaagaaaac tccatggcta acagacctac ttgggagaga acgcagcgct
     2221 cccagcccgc tgtggaggca actgtgaagc gtggcctcgg gactgaaggc ctggactttg
     2281 ccgtaccgtt ccagttagtg tagacaggaa gagaattggt gctgcagaag tgtgtccgac
     2341 acagagccgg tgtgaaacct cgcgttagtc tgacacgcac ttactcatcc atttctatag
     2401 gatgcacaat gcacgtgggc ctgagactga ggcctgattt ctgcaggcga gaagggggtg
     2461 ggattgctac tttgtttcct gttggttttc ctaatgtatc aaggagagat ccagacatcg
     2521 ttggccaggg ctcctgttgc cactttctgc agttgtgttt gtgtgcggat ctggaccact
     2581 ttgtcttata ttttcgtggc ggtggtcccc atgccgaccc tctgccaagt gcccctgcgg
     2641 gatgggagga gtgagataag agttggtggt tgtttctatg cattctggct gccctctggg
     2701 ctgcctccct tcttcccgtg ctgcacgtcc gtctctttcc ctgagtttga gattgaaccg
     2761 actgcttggg tgagaagtgt cctctttaat gaggctctct accgaccaac tgaagtatag
     2821 acttttctgc tggacaatct gcatgggcat caccccctca cctgcatgta cccaaaaagg
     2881 ggtccagagc caaggctcct gtagtcattg tccctctctg tgctcaagga gttcctttcc
     2941 aggaggaaaa gatctgtacc ttaggcagat aacagagaag acaatggagg agcaattggt
     3001 catagtcttg gttccctccc acccaacagc tgcacactat ctgcattttg ggggggaagg
     3061 tgggttgact tcagctcttt ggatgacctt cagggaggca caggagctgg gaaaagatac
     3121 agaactacag actttggaac cagctgagaa gagaacaaac tcatgggtgc tggtgcttga
     3181 atttagccag gctcctcaag caccttgtgc atgcctcaga ccctggaccc tagccccttc
     3241 ctgccctgca gcctgcagtg ccagccaaca gatcccttca ccacagggtt tggttttgct
     3301 ggcttgaaga caacaaatgg tcttagagct cattgagacc catagcttca tatggctgct
     3361 ccagccccac ttagcgttct tactccactt ctggggctaa tgtcagcatc tatagacaat
     3421 taatagacta tttaaaaaaa aaaaccacct tttaaacagg aaatgaaagg catttgatgc
     3481 agaacttttg catgacgaca tagaaataat ttaaaaatag tgtttgttct gaatgttggt
     3541 agtcccttca tagctttgtt acaatgaaac cttgaagata tttaataaaa taacctttaa
     3601 acagtc
//
LOCUS       NM_001437856            3684 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 6, mRNA.
ACCESSION   NM_001437856 XM_017599576
VERSION     NM_001437856.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017599576.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.957026.1,
                                           SRR26360194.341829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1092           JAXUCZ010000015.1  3598315-3598347
            1093-1137           JAXUCZ010000015.1  3601575-3601619
            1138-1186           JAXUCZ010000015.1  3604223-3604271
            1187-1300           JAXUCZ010000015.1  3605519-3605632
            1301-1376           JAXUCZ010000015.1  3607566-3607641
            1377-1471           JAXUCZ010000015.1  3607997-3608091
            1472-1716           JAXUCZ010000015.1  3609598-3609842
            1717-3684           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3684
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1704
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 6 is encoded by transcript variant 6;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 6"
                     /protein_id="NP_001424785.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKS
                     SSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSLVPEGRSPRD
                     RTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEA
                     LGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQG
                     RPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1303..1686
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1303..1686
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1092
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1137
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1186
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1300
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1376
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1471
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1716
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..3684
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaaga aaaggaagtc gagttccagc
     1081 gtgcacctaa tggagccaca aaccaccgtg gtacataatg ctacagatgg gatcaagggc
     1141 tccacagaga gctgcaacac caccacagaa gacgaagatc tcaaagctgc cccgctccgc
     1201 actgggaatg gcagcttggt gcctgaagga cggagccccc gggacagaac agccccctct
     1261 gcaggcatgc agccccagcc ttctctctgc tcctcagcca tgcgaaaaca ggagatcatt
     1321 aagatcacag aacagctgat agaagccatc aacaatgggg actttgaggc ctacacgaag
     1381 atttgtgacc caggcctcac ttcctttgag ccagaagccc ttggtaacct cgtggagggg
     1441 atggatttcc ataagtttta ctttgagaat ctcctgtcca agaacagcaa gcctatccac
     1501 accaccatcc taaacccaca tgtccatgtc atcggcgagg acgcagcttg catcgcctac
     1561 atccggctca cccagtacat cgatgggcag ggtcggcctc gcaccagtca gtcagaggag
     1621 acccgggtgt ggcaccgccg ggatggcaag tggctcaatg tccactatca ctgctcagga
     1681 gcccctgctg caccgctgca gtgagctcag gcacaggggc attaggagat tccagctgga
     1741 ggctgaacct tcgaagtcag tgactctgga gggcctgagt gacagccgcg gtcctgtcca
     1801 tttgaggttt aaaacaatta cattacaaag cggcagcagc caatgcacgc ccctgcatgc
     1861 agccctcccg cccgcccttc gtgtctgtct ctgctgtact gaggtgtttt ttacatttaa
     1921 gaaaaaaaaa agaaaataag attgttttaa aaaaaaatgg aattcatacc atgatgcgtt
     1981 ttaaaacaac tgatagcctt tgggcttgaa gaaggcagga gtttgtatga tgctcatcca
     2041 ggcgtgaaca gagggctcac ccactggctt tgaagaggtg agcttggcct caggccccca
     2101 tggactcggg ggggaccagg caaggactct tgacagagct ttggtcatgg acagagccat
     2161 gctgtggttg cagccccggt ggtgacctga tcactccagg tctaggagtg gacttcttca
     2221 gaatatacat tgacacctag tatgagaaag aagaaaactc catggctaac agacctactt
     2281 gggagagaac gcagcgctcc cagcccgctg tggaggcaac tgtgaagcgt ggcctcggga
     2341 ctgaaggcct ggactttgcc gtaccgttcc agttagtgta gacaggaaga gaattggtgc
     2401 tgcagaagtg tgtccgacac agagccggtg tgaaacctcg cgttagtctg acacgcactt
     2461 actcatccat ttctatagga tgcacaatgc acgtgggcct gagactgagg cctgatttct
     2521 gcaggcgaga agggggtggg attgctactt tgtttcctgt tggttttcct aatgtatcaa
     2581 ggagagatcc agacatcgtt ggccagggct cctgttgcca ctttctgcag ttgtgtttgt
     2641 gtgcggatct ggaccacttt gtcttatatt ttcgtggcgg tggtccccat gccgaccctc
     2701 tgccaagtgc ccctgcggga tgggaggagt gagataagag ttggtggttg tttctatgca
     2761 ttctggctgc cctctgggct gcctcccttc ttcccgtgct gcacgtccgt ctctttccct
     2821 gagtttgaga ttgaaccgac tgcttgggtg agaagtgtcc tctttaatga ggctctctac
     2881 cgaccaactg aagtatagac ttttctgctg gacaatctgc atgggcatca ccccctcacc
     2941 tgcatgtacc caaaaagggg tccagagcca aggctcctgt agtcattgtc cctctctgtg
     3001 ctcaaggagt tcctttccag gaggaaaaga tctgtacctt aggcagataa cagagaagac
     3061 aatggaggag caattggtca tagtcttggt tccctcccac ccaacagctg cacactatct
     3121 gcattttggg ggggaaggtg ggttgacttc agctctttgg atgaccttca gggaggcaca
     3181 ggagctggga aaagatacag aactacagac tttggaacca gctgagaaga gaacaaactc
     3241 atgggtgctg gtgcttgaat ttagccaggc tcctcaagca ccttgtgcat gcctcagacc
     3301 ctggacccta gccccttcct gccctgcagc ctgcagtgcc agccaacaga tcccttcacc
     3361 acagggtttg gttttgctgg cttgaagaca acaaatggtc ttagagctca ttgagaccca
     3421 tagcttcata tggctgctcc agccccactt agcgttctta ctccacttct ggggctaatg
     3481 tcagcatcta tagacaatta atagactatt taaaaaaaaa aaccaccttt taaacaggaa
     3541 atgaaaggca tttgatgcag aacttttgca tgacgacata gaaataattt aaaaatagtg
     3601 tttgttctga atgttggtag tcccttcata gctttgttac aatgaaacct tgaagatatt
     3661 taataaaata acctttaaac agtc
//
LOCUS       NM_001437834            4190 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 3, mRNA.
ACCESSION   NM_001437834 XM_017590607
VERSION     NM_001437834.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4190)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4190)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4190)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4190)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4190)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4190)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4190)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4190)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4190)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4190)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017590607.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1422082.1,
                                           SRR26360176.737065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1397           JAXUCZ010000002.1  217908119-217908153
            1398-1457           JAXUCZ010000002.1  217912214-217912273
            1458-1499           JAXUCZ010000002.1  217914468-217914509
            1500-1548           JAXUCZ010000002.1  217916935-217916983
            1549-1624           JAXUCZ010000002.1  217946550-217946625
            1625-1719           JAXUCZ010000002.1  217955065-217955159
            1720-1948           JAXUCZ010000002.1  217957098-217957326
            1949-2037           JAXUCZ010000002.1  217958485-217958573
            2038-4190           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4190
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..2015
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 3 is encoded by transcript variant 3;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 3"
                     /protein_id="NP_001424763.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAKSLLKKPDGVKINNKANV
                     VTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLIE
                     AINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNP
                     HVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTV
                     PIKPPCIPNGKENFSGGTSLWQNI"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1365..1367
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1422..1538
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1503..1505
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1512..1514
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1521..1523
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1551..1934
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1551..1934
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1983..1985
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1995..1997
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1397
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1457
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1499
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1548
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1624
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1719
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1948
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2037
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..4190
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agccaagagt ttgttgaaga
     1381 aaccggatgg ggtaaagata aacaacaaag ccaacgtggt aaccagcccc aaagaaaata
     1441 ttcctacccc ggcgctggag ccccaaacta ctgtaatcca caaccctgat ggaaacaagg
     1501 agtcaactga gagctcaaat accaccattg aggatgaaga cgtgaaagca cgaaagcaag
     1561 agatcatcaa agtcactgag cagctgattg aagctatcaa caatggggac ttcgaggctt
     1621 acacgaaaat ctgtgatcca ggcctcactg cctttgaacc cgaagcattg ggcaacttag
     1681 tggaagggat ggactttcac agattctact ttgaaaatgc tttgcccaaa atcaataaac
     1741 caatccacac tatcatcctg aaccctcacg tacacctggt aggggatgat gcagcctgca
     1801 tagcatacat tcggctcaca cagtacatgg atggaaatgg aatgccaaag acaatgcagt
     1861 cagaagagac tcgagtgtgg caccgccgtg atgggaagtg gcagaatatt cactttcatc
     1921 gttcggggtc cccaacagtc cccatcaagc caccctgtat tccaaatggg aaagaaaact
     1981 tctcaggagg cacctctttg tggcaaaaca tctgaaaacc attcacattt gggtcttcta
     2041 attgtcaaca gtgccacgtc ttcattctgt cctcaaggca cctggcgggg tgatcctggg
     2101 acatcctctc ctcttcatgc atgtttctga gtgcatgaag ttgtgaaggt tctacgtgta
     2161 atgcatatgt gacacgtcat cttaccatgt gacacgccat cttaccatgt attccttcct
     2221 gtacattgtt tacactccag ctactggacg gatgttccat gcaaacgtca gttactgctg
     2281 gcaaactaaa gagggagctc cgacaagaaa actccgcaat actccaagtt cagctgatcc
     2341 atcaggtttc tctgtggatg ccaagattca aaagacttca taaaattact gttcaatgaa
     2401 tgacagtgtg taagaggaaa ggaaatcttt caagaatgct gccattaatc tatttgggct
     2461 tctcattggg attttggggt tgattttttt ttcatttttt aaggcaaata tatatatata
     2521 tatatatata tatatatata tatatatata tatatatatg ccttcagttc ctggtagaaa
     2581 tgaatggatg ccttttctct gaaagtgttg gtgttggata aatggatggc tatgtgagcc
     2641 aagtcctggg tgattgtagg agcaagaatc gtttgctgtt ctaccatcaa agccatgttg
     2701 atttgggtcg agctctgtat actggaaaaa ttcacatcat tttctagttt gattgctttc
     2761 agataggcac agttctggtg aatgcttggc actgatcttg gtttttcttt cctaaatctg
     2821 tgttctgttt tcattatata ctatttgctc ctttcctttg tatttgtttt cttttcccac
     2881 tcttttcttt atctttctct ctcccacttt ctttcttttt tatgttttcc tttctatagc
     2941 tgatagtgtg taaaaacagt aacatttgca tatgaagtta aaataaaaat caaggtcttc
     3001 tagaagctaa aactagcact tccggtctct cacggggctg tggagttgtt agaagattta
     3061 aataaatact taaataagag aggaatgaat tcagcttagg ttaccacttg tgcataggta
     3121 tccttgctct gttgaaagtg ttggaattgt tgagacttaa gctaacagca gtaagagcct
     3181 gcttacacag tcctggttct ccccaactag atattgaaga ccaagtggag cctgaccagg
     3241 gttgcatgca gagcacttgt tttggacctt ccagactagg aggcatttac tgcctcactt
     3301 tcactagcta gccacaggaa gagtgttctc catcctccta gaggttgaac ttgaccttcg
     3361 tgactagtgc agttctagct tctctcttga gtcacagtag catcctgatg ccaggagtta
     3421 ggcttttgtc cagattaaaa caacgaggaa aaggaaatgc cccagttttc tttccgtttc
     3481 ccatttcttc tttgtcgatt cggtccctgg gagactgttt ctccgcgctg aactgcttta
     3541 tggtgcatgg aatctccatc agcgtacttc taccctagcc actcacactc cttagaagct
     3601 gatttttaaa gcagaagcaa ggaagcaaaa gtaaaacact cccttcccct ctttttcctc
     3661 atttcacctt ttggtgttga ttgctaatca ctttagatat attgttgcta gtgaatgtat
     3721 gatagatggg ttgaagcttt tctgataatt agcacatgat ttaaaacaat atatatttaa
     3781 aacaaatata tacagtacat gtattgagcc gtgttaacct gccaatgaga tctgtgaaaa
     3841 acgtaatggc ctcacttttc cctttgaatt tcttttacct ttctgtgaag cagctctgcg
     3901 tggcatacat gtatttaaaa acacaaatag tggtagaatg ggtttttttt ttacactttt
     3961 aacttagcat gtggtgttga agtattacca tagatccagt ttgtcttctg cactaagatg
     4021 tgaggaaatc gtgatttgtt ctctccagca cagtggaatt acaccttcat catcttctat
     4081 tgttttgaaa acactgcagt ttaccatggg acactgtata taattcttgc cgtaatggta
     4141 aatgacaaat tgatatattt aagagttaat aaatttgtga tttctgctga
//
LOCUS       NM_001437804            8543 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 3, mRNA.
ACCESSION   NM_001437804 XM_063288655
VERSION     NM_001437804.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8543)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8543)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8543)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8543)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288655.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1250329.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000001.1  9595970-9596116     c
            148-315             JAXUCZ010000001.1  9497140-9497307     c
            316-396             JAXUCZ010000001.1  9468266-9468346     c
            397-555             JAXUCZ010000001.1  9463224-9463382     c
            556-1102            JAXUCZ010000001.1  9454995-9455541     c
            1103-1305           JAXUCZ010000001.1  9448660-9448862     c
            1306-1462           JAXUCZ010000001.1  9447057-9447213     c
            1463-1518           JAXUCZ010000001.1  9441551-9441606     c
            1519-1580           JAXUCZ010000001.1  9435618-9435679     c
            1581-1718           JAXUCZ010000001.1  9433972-9434109     c
            1719-1795           JAXUCZ010000001.1  9426874-9426950     c
            1796-8543           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8543
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..147
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    129..131
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     CDS             135..1811
                     /gene="Phactr2"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 3"
                     /protein_id="NP_001424733.1"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MDKAVDGLDKASIANSDGPPAGSQTPPFKRKGKLSTIGKIFKPW
                     KWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQDGDVTVNFENSNGHM
                     IHIGEEATQEENVGKPEEGNVSVCEKGPPREEQAEEKTAGSSHPKKTTGSKASSSPSA
                     SSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLSPNTVTSETSSLKGELS
                     DTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPALPLPPEDPCTIALDTP
                     MVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSREQAKCFTTKDGPGKAG
                     PQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTDDDDEEDDDDDSTGESA
                     LASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIGTKLVRRLSQRPT
                     TEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTD
                     SPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP"
     misc_feature    318..383
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    318..383
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    1335..1412
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1335..1412
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1452..1526
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1452..1526
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1563..1640
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1563..1640
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     exon            148..315
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..396
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..555
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1102
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1305
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1462
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1518
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1580
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1718
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1795
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..8543
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacagtgcg tgaagtgtgt tctgtgtgcc agcaagggct gataatcagc agaagggcag
       61 ggtgctctgt tagccagaag agcccgggct tccgggctgc cagctgcccg gactcgcctc
      121 gccacttctg agccatggat aaagccgttg atggactaga caaagcctcc atagcaaact
      181 cagatggccc cccagcaggt tcccagacac ctcccttcaa gagaaagggg aaactctcca
      241 ccattggtaa aatcttcaag ccttggaaat ggaggaaaaa gaagaccagt gacaagttta
      301 gagagacctc agcagtatta gagaggaaga tatccaccag acaaagtaga gaggagctga
      361 taagaagggg cctgcttaag gaattgcctg atcaagatgg agatgtaaca gttaactttg
      421 aaaattcaaa cgggcacatg atacacatcg gagaggaagc tacccaagag gagaatgtag
      481 ggaaacctga agaagggaat gtctctgtgt gtgagaaagg accacctcga gaggaacagg
      541 cagaagagaa gacagctggt tcctctcacc cgaagaaaac aactggttcc aaagcctcat
      601 cctcaccatc tgcttcgtcc acctcctctc atcccagagg acccaaggag tcactcactg
      661 gcaaagcagg cgcggttggg accacaaggg gcaagaaaaa gattagcaag cagccagcag
      721 cggcggcatc ccgactgtcc cccaacacag tcacttctga aacgtctagt cttaaaggag
      781 agctctcaga cactggggta gagagcctca agccagagga aactgttgct ggagcagagg
      841 aggaggccac aggcaaaccc aaggcggtcg tcgtcgctct gccacctgtc acagtaccgc
      901 catcttcacc tgcccttcct ctgccccctg aggatccatg cactattgcc ttggacactc
      961 ccatggtcct agtcagtgat ggacccaccc tgcccatctc tgccttagaa acaagtccgc
     1021 tccctgggac tgaagaacca gcgaacagaa ccactccgta ctcaagcacc ggcttaggtg
     1081 ggagccgaga gcaggcaaaa tgttttacaa ccaaagatgg gccgggaaag gctggacctc
     1141 aattgctgac ccctggacag atgggagact cattagaatc cttcagtgcc ccagaggatg
     1201 aggccccaag agagtaccaa gccaatgact ctgactcgga tggacccatc ttatacacag
     1261 atgatgatga tgaagaagat gatgatgatg acagcactgg agaaagtgca ttggcaagta
     1321 agatcagacg aagggataca ctcgccatca aacttggcaa cagaccatcc aagaaagagc
     1381 tagaggacaa aaacatcctg cagcgaacgt ctgaagaaga aaggcaggag ctgcgacaac
     1441 agatcggaac caagctggtc aggagactca gccagaggcc aaccactgaa gaattagagc
     1501 agagaaacat cttaaaacaa aagaatgaag aagaggagca ggaagcaaaa atggaactca
     1561 aacggaggct cagccggaag ctcagcctaa gacctactgt ggcagagcta caagcccgaa
     1621 gaatcctgcg gtttaatgag tatgtggaag tcacagattc cccggactac gacagacgtg
     1681 cggacaagcc ctgggccagg ttgacacctg cggacaaggc agcaataagg aaagaactaa
     1741 atgaatttaa aagcacggaa atggaagttc acgaagagag tcgacagttt acaaggtttc
     1801 accgtccata atgaagcatg ggacagcttg gaaataagga ccctgacatt gcactgagat
     1861 ttgaatgtgt gtgtttccgt ttcgttgtgg tgaaggaggt gtacgactcg gctttggttg
     1921 aagacgctcc tcaccctgac agcccagacg agggcaacaa gctgagaggc ggatgcggca
     1981 agcctggctg cccacggtgt gcactgatat aaggggcact ctgactctct cagctatgtt
     2041 tcagcgggaa ttttaatcaa agaagacaag cagaagacaa tcgccagttt ggctaccaga
     2101 aagccatacg gtatagcacg tgtgggttca caaacaatag acattggaat tgctggtggc
     2161 caccccaaca gggtgggagc tgaaactgag aaagagagag aaccgtttca ttatgttaat
     2221 gaagagaaga agagtgaaga gaagtatatt tttgaagtag gcgttcggta gctgaggact
     2281 tcctaaggga tttgggaacc tactcaacca acgtagattc cttaaagact tcattctaga
     2341 acattcttgt ttcaccaata atggttctgt gtagtagcct cttttttttt tttttttaat
     2401 gttgtgccag tgaacccagt tgccagaaac aaatatgagt gttcattcaa tgcaaggagc
     2461 tcctaccagc tctcaccaag catgcttgct cttgctgtgt tgcatgcctt tcagtagtac
     2521 agccaagccc acactttctt atattgcttc cctaacgtat gagcgctcta caagggtaac
     2581 aggaatgagg tcagatgcaa tgtgaccctg taaaactgtg gcaagcttca gaaataaatc
     2641 ttctgctctt tccctgtctt gattctctcc aaagtcagga aaccatcctt tagctaaaga
     2701 agatgacccg gacagtcatg gtacccttta aacactcaat ccagagttgt cacttaagca
     2761 acatacaagt gtctgctgcc tgctccaagt cctgagaggg gatttaaaga acataccaga
     2821 tagtttaaaa tcctgcatta attttttttt aatattaggt tgctgctatt ttttttaaaa
     2881 aaaagtgaaa cagtaaaaac caagcatatg aatttaacaa aaatatcctg aggcttaaag
     2941 gaacacagaa gacgacttct ggtttatgta aaggaaacct taccttctct gatgaatttg
     3001 tggatcatat ccatataccc ggtatttact ccccatgcca gagaagcagt aagatccccg
     3061 ggccagcttc cccaggagtc tgtaatcagt cttgtttaca ttaaaaagct tcccccctca
     3121 aattgttctc ttcagtgtcc ggccccagca cagaacccca gaagggctta cttgtgatac
     3181 taccttgaat ttcgttgtcc cttaacaatt gttttaagcc ccttggatta aaagaagaag
     3241 aaaaagaagg cagaatctat atcatgcttt ttttttcctt aagaaggcag aatctatacc
     3301 aggtctatct cattctttga tctggagcta tgccgattct gaagcctgta attttctatt
     3361 tcgagtgaac agtcagcctc gaatcagtca agtaagtgta ggccctgcca ttctgtggta
     3421 tctggaggga ccgcttgaaa tttgatgatt tcatttaaaa gtgaacgtgg ttagcggcag
     3481 cggactgttg tgaaagccca gaggaaccgc gccacgaggt aaccagcgtt catgcaccca
     3541 ccgccgtgct tagccgtttg cggtaataag acaaggctgc tgcctacact agttcgtctg
     3601 gctaacagca tgaggcagac tttgcttttg aaatagtgtc tgtgcgtgca ctagtgtttg
     3661 tctttgtctt tgggggcttg ctcgttctat tgttgttttg cagtgccggg actgaaccag
     3721 gcccttgcgc atgctctgtg tactctaacc cctgagccaa cacccctaac cttcgtttga
     3781 caagagtctc aactcaaccg tgaatagtaa ttttgttctc attacttata gagtagtttt
     3841 ccctcgtgat atcctactat cgtcttagtg tcgtgggaaa aagtgacaag acaggtgatg
     3901 ttccttcgtc tatgcttata atctcgaaac gttttaaaaa ccttctaatg aaatgtcctc
     3961 aaaatgttgt aaattcaaga caggagcaac acggcttgcc attcaaagtg tgtttcatag
     4021 aaagtttctg tctggttggt caaaagaacc ttttttcccc actagtggtg caggtgacac
     4081 aggttttaat cttccacagt taatgttcaa aatgccacgc atcgttgaag ctcccagttc
     4141 agcccccagt actgcacaaa cgaaaatctg tctcctgata acatctgcca gattggtgtt
     4201 acctacacct tttcttcata ctaactgata catttcaaga agcttttgtg agaaagttta
     4261 gaaagctaaa aaattaacta ctaacggtct aatatttaag taacctggga ccactgatga
     4321 cttcattatg atggcctagt acctgtttta aaagccgtgg gaagaattaa aatatcacga
     4381 gccaagctgt acttctcaga ataaggctct actttgctgg gtaatttgta aaggcagaaa
     4441 cgtttaaagg ctacatagcc ttagcagcag ctcactcaca ggtctccatc caggcatccc
     4501 cacagaaggc aaagctccct ctccctgtaa ttaccgctct gcccactgcc agcatttctg
     4561 cagtccaacc aacaagcagc tactctttaa gaaaataaat gtgtgcagaa accagggcgt
     4621 gcgtgcgtgc gtgcgtgtgt gtgtgtgtgt gcatgtgtgt gttgccattg taacacaatt
     4681 ccagtttttc actaaagcat accattaggc aatggagtga gcgttcctga ctccggagtt
     4741 atactaagga aaagaaaatt agcccacctc actggaggcc ccaacaagaa aagaaactgg
     4801 accagacaga aaagccaaag tggccattcg gagggagacc ctgttggtat tacggtattg
     4861 agaagacact aagctccctt cacgcagcag cctcgtggtc atcaccaacc aaccaacgtg
     4921 acgaatgcag tcctaatccg tgttcgccag gggcaccttg gctggtcatt tcctgtaggt
     4981 atgaaatgtc tggtggtttt gtgtgagcta taatttacct ttatgtttat tccttaagtt
     5041 gttttaaccc gaagtctgca atatccagag aaccatctcg ggtatttgag cacctattaa
     5101 aggaaaggca agcatatcca tctctctgcc ttcccagtga agaagctgac tttctggttt
     5161 ctttcttctt gcccttatca acccaatgaa cgcagttctc tgtctccgat gtcgggagaa
     5221 agttctggaa cttaattgca aatatattta aggaaagaga agaatctaat aagcctttca
     5281 aaaaccacca agtatggaaa tgagtcgtga gtcctgagaa aaggtcaggc aggctttgta
     5341 tcctgtaatt aacccagcga tccattggcg cttttttaaa aatacaggag tttgtactcg
     5401 agggagaaca tgggttcatc tcacatgtcc agatacgtgc aaccccacag caacacatgc
     5461 cggacacccg tgaccgttag gctgtaggca cactagaaag aggccggtct gccatgtagc
     5521 agcggtctgt ctgcatttga acagtaaaaa atagtttcct cttctccatg tcttgttcta
     5581 aaacatccat cctgtgttgc ttgggcttgg ccctagccgc gtattttaga gacatcaaca
     5641 ttccttagtg tatgtgaaac gggcttaatc taacacagga tgtatggatt tatgtccttt
     5701 tcctcctcgg cacggcggat ttgtttatgc attcctaaat ccccacttca cttacttatc
     5761 gttacaagta cggggagctc tactggggag gtcatttttc cttcagggct gtacaggaca
     5821 cagattgtcc cttcacccct taaaatgatt aatcctttgt tagtattcgc tgtctattga
     5881 ctggctgata tgtttttatt taacaaaagc agaacgaacc tttaggagat atgtgctaga
     5941 ggggccaacg gggacaaaaa ataagcaatt gtcaaattaa tgagaacagc ttcctgaaag
     6001 aaaccatatt ctcaggcaac tcaaagtcga gctccacaga gggactctag gtctccctac
     6061 agaggcactc ggggaccaaa gggtgatgga gatggaggtg accattctcg tttttgcttc
     6121 ctgtttccct tttctaatcg ttaagtctaa aacctctttt gaagcttgaa ccactgttgg
     6181 catttctaga aagcaactgt aataggggct agtgcttttc tttctttctt tctttctttc
     6241 tttctttctt tctttctttc tttttttagt atgactgtat tttgttttgt ttgtttgttg
     6301 aggccagctt caccccataa ttttttttaa aaaaatttca ttttttacat ttaaaaaaaa
     6361 tgcaagtttt tttttcccaa agaaatggag agtcctgtgg ctgctatccc ggcctaatgc
     6421 cagtttttaa ccatgttggg ttgtgctgca gggaaatgcc agttagcctg ttgcttcttt
     6481 aacacagctg cctgtgaaca aagaagcgct gatagatgtc tcccggtggg ggtgctgttg
     6541 gtatttggat ctgggtaaat ccttgctgtg ctgaaatgta ccacatgttg caagatgttc
     6601 agtatcctgg gctcctggtg actcaacacc agacattgtg agaaccggaa aaaaagaaaa
     6661 gaaaagaaaa gaaaagaaaa gaaaagaaaa gaaaagaaaa gagaagaaaa aagcttcccg
     6721 tttgcctgca tagaaggata aacccctcac ctgagtgcca ctgtctcctg caacaagggt
     6781 acatggggga acctgcctgt ctctaaatac catgtctact gccttgcacg tctctaccca
     6841 cttctctttc aaagccttct gcttagatgc agcttaaact ggcctgttcc ctagaaaaga
     6901 gcttcctagg tagtcttgtc cattacggtg ggcagcgtga catggcctga tatttctgga
     6961 gggtacacga agcaagtctt gttcattact tctgtgttac ttcagaacta gactcctggt
     7021 tgccagaaca cagtgtctct gagtaaaaca ctggtctttg gaactcagca ttggattcta
     7081 cctggtcata ctgaagaccg agttgcaaaa agagtctccc ttcctcctgt tgacaacgga
     7141 gttaatccac acaaaaagac acggggactc cctcgtgtaa acatccacac ggttccgctt
     7201 tcctaataag acgtgcaaat atgacatgtt ggcaggaacg taggtaaact ggattgcatt
     7261 catgctgttc acaccacaga cgggcaaaac gaaatgagtt ttcccccagg tgtagctcga
     7321 tcaagctgtg ctaaccgtac agaaagacgc tctttacgcc actgaaatta aatagtcagt
     7381 gggtcttgaa aaatatttag atgaattgca gctagctgca aggatggaat taattcctcc
     7441 cattcttcac attaaaattc tgaagactcc ccgcccctcc cccttctttt aagcatagca
     7501 acttggagtc agtaaaggtg gccatagcgt aaacctatag atggtgcttt aaaacaaaat
     7561 cgtatctttc ttaatagcag tattttttaa agcagagaat agactgaaag aagtaaatgc
     7621 ggcagaacgc tgttccacac tcaggtaaat tttgtggttt attaaaatgc caataatatt
     7681 tgtgcacttg ccagcgtcag gggcttttcc cttaatggat gctctcggtg tgattttttt
     7741 cctcttcttt aactgtatcg ttacattgtt tagagagcat ccaccaccag gatttgccac
     7801 cgtagtgata actagcatta ggaaagaatt accgagaact gagggtcaaa ccactttcat
     7861 cacctaaacg acaggcacta gttctttagt atttcttcag tggcttgggt gtgcccatgt
     7921 attcaaagca ttccgcacga attttaccag ttaaataccg gctgaaaagt cagaccagtc
     7981 tctctccgca cctcctctct ctgtaacaat gtttcgtttt tgttttgttt ttttcccata
     8041 atgagctgtc tgtgttcttt tgttatttca aactttggtt caagtggtag caatggtaca
     8101 cactgtgatg gtggggagac tagctgggtg agtctctagt gtgtgatcta atctttacat
     8161 gggtgtgcta tctgtgggtg ttgataactg gaactgtacc cggacaacac gacagtttct
     8221 ctctcttcct gttcctgatt cactactata tcatagtacg tgggtatgac ccctgcgagt
     8281 atccacaccg aagcctatgt attccacaat tgtaacctga aagaccatgc attatctttt
     8341 tttaattcat actggtgttt gtgttattta aagtggaaaa ttatacccta tctagtagta
     8401 taatgtaata taataggata ctccgctgtg cacagttcca agtgccttag aacattgttt
     8461 agctttccta agtatacgta aatgcatata tgtgtgtata aaattgggaa atgttacctc
     8521 aataaagtca ttgggaaatc cta
//
LOCUS       NM_012630               1617 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus prolactin receptor (Prlr), transcript variant 2,
            mRNA.
ACCESSION   NM_012630
VERSION     NM_012630.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Vergara-Castaneda,E., Grattan,D.R., Pasantes-Morales,H.,
            Perez-Dominguez,M., Cabrera-Reyes,E.A., Morales,T. and Cerbon,M.
  TITLE     Prolactin mediates neuroprotection against excitotoxicity in
            primary cell cultures of hippocampal neurons via its receptor
  JOURNAL   Brain Res 1636, 193-199 (2016)
   PUBMED   26874070
  REMARK    GeneRIF: This study demonstrated that the Cultured neurons
            expressed mRNA for both PRL and its receptor (PRLR), and both PRL
            and PRLR expression levels changed after the excitotoxic insult.
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Rojas-Duran,F., Pascual-Mathey,L.I., Serrano,K., Aranda-Abreu,G.E.,
            Manzo,J., Soto-Cid,A.H. and Hernandez,M.E.
  TITLE     Correlation of prolactin levels and PRL-receptor expression with
            Stat and Mapk cell signaling in the prostate of long-term sexually
            active rats
  JOURNAL   Physiol Behav 138, 188-192 (2015)
   PUBMED   25446202
  REMARK    GeneRIF: Results showed that an active sexual life, with constant
            execution of sexual behavior, produces a sustained increase in
            serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   Arumugam,R., Fleenor,D. and Freemark,M.
  TITLE     Knockdown of prolactin receptors in a pancreatic beta cell line:
            effects on DNA synthesis, apoptosis, and gene expression
  JOURNAL   Endocrine 46 (3), 568-576 (2014)
   PUBMED   24114406
  REMARK    GeneRIF: PRLR signaling is required for DNA synthesis and survival
            of rat insulinoma cells
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   Ali,S., Pellegrini,I. and Kelly,P.A.
  TITLE     A prolactin-dependent immune cell line (Nb2) expresses a mutant
            form of prolactin receptor
  JOURNAL   J Biol Chem 266 (30), 20110-20117 (1991)
   PUBMED   1718958
REFERENCE   7  (bases 1 to 1617)
  AUTHORS   Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.M.,
            Edery,M., Djiane,J. and Kelly,P.A.
  TITLE     Expression of two forms of prolactin receptor in rat ovary and
            liver
  JOURNAL   Mol Endocrinol 4 (8), 1136-1143 (1990)
   PUBMED   2293022
REFERENCE   8  (bases 1 to 1617)
  AUTHORS   Zhang,R., Buczko,E., Tsai-Morris,C.H., Hu,Z.Z. and Dufau,M.L.
  TITLE     Isolation and characterization of two novel rat ovarian lactogen
            receptor cDNA species
  JOURNAL   Biochem Biophys Res Commun 168 (2), 415-422 (1990)
   PUBMED   2159291
REFERENCE   9  (bases 1 to 1617)
  AUTHORS   Boutin,J.M., Jolicoeur,C., Okamura,H., Gagnon,J., Edery,M.,
            Shirota,M., Banville,D., Dusanter-Fourt,I., Djiane,J. and
            Kelly,P.A.
  TITLE     Cloning and expression of the rat prolactin receptor, a member of
            the growth hormone/prolactin receptor gene family
  JOURNAL   Cell 53 (1), 69-77 (1988)
   PUBMED   2832068
REFERENCE   10 (bases 1 to 1617)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_012630.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19304.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000002.1  60909682-60909786
            106-128             JAXUCZ010000002.1  60992578-60992600
            129-238             JAXUCZ010000002.1  61012956-61013065
            239-371             JAXUCZ010000002.1  61016362-61016494
            372-541             JAXUCZ010000002.1  61018046-61018215
            542-711             JAXUCZ010000002.1  61027952-61028121
            712-853             JAXUCZ010000002.1  61029594-61029735
            854-953             JAXUCZ010000002.1  61030181-61030280
            954-1023            JAXUCZ010000002.1  61030794-61030863
            1024-1617           JAXUCZ010000002.1  61051290-61051883
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1617
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
     exon            1..105
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            106..128
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            129..238
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    151..153
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="upstream in-frame stop codon"
     CDS             184..1116
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; PRL-R; lactogen receptor"
                     /codon_start=1
                     /product="prolactin receptor isoform b precursor"
                     /protein_id="NP_036762.1"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
                     /translation="MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     QMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFT
                     MEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESS
                     VEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLETGSPSKYKVDLYLALPGGFQKLDNAGELDY"
     sig_peptide     184..240
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    238..528
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    238..528
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    343..345
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    478..480
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    547..840
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    547..840
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(547..549,760..762,805..807)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(547..549,760..762,805..807)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    562..564
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    811..825
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: WSXWS motif"
     misc_feature    order(811..816,820..825)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(811..816,820..825)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    871..942
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     transmembrane region"
     misc_feature    967..993
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Box 1 motif"
     exon            239..371
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            372..541
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            542..711
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            712..853
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            854..953
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1023
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1617
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacatagaa gagtaatcat ccagagaggg gctctggtgg agctcactag ccattgactg
       61 ttcttttcag aagtctggac tccctgacct acaaggcctc tcaagctaaa ggacacttct
      121 ctgtgaaggg agcctctgat acattgccta tagcaagaag aaggggccaa cctgaagaaa
      181 aacatgccat ctgcacttgc tttcgtccta cttgttctca acatcagcct cctgaaggga
      241 cagtcaccac cagggaaacc tgagatccac aaatgtcgct ctcctgacaa ggaaacattc
      301 acctgctggt ggaatcctgg gacagatgga ggacttccta ccaattattc actgacttac
      361 agcaaagaag gagagaaaac cacctacgaa tgtccagact acaaaaccag cggccccaac
      421 tcctgcttct ttagcaagca gtacacttcc atctggaaaa tatatatcat cacagtaaat
      481 gccacgaacc aaatgggaag cagttcctcg gatccacttt atgtggatgt gacttacatc
      541 gttgagccag agcctcctcg gaacctgaca ttagaagtaa aacagctaaa agacaaaaaa
      601 acatatctgt gggtaaaatg gtccccaccc accataactg atgtgaaaac tggttggttt
      661 acaatggaat atgaaattcg attaaagcct gaagaagcag aagagtggga gatccatttt
      721 acaggtcatc aaacacagtt taaagttttt gacctatatc cagggcaaaa gtatcttgtc
      781 cagactcgct gcaagccaga ccatggatac tggagtagat ggagccagga gagttccgtt
      841 gaaatgccaa atgacttcac cttgaaggac acaaccgtgt ggatcattgt ggccattctc
      901 tctgctgtca tctgtttgat tatggtctgg gcagtggctt tgaagggcta tagcatgatg
      961 acctgcatct ttccaccagt tcctgggcca aaaataaaag gatttgatac ccatctgctg
     1021 gagactggtt ctccaagcaa atacaaggtg gatctgtacc tggcccttcc tggaggattc
     1081 cagaaactgg acaatgcagg ggaacttgac tactgaagct gcagactcaa ataggagcct
     1141 ctcaaaatgg gttctaccac catcgcaaca aatgctgaga acaagacaga aatttcccag
     1201 tgccaataat ctagtatcca ggacgcctgc ctggttagac tttaaatttg ctcaatgaca
     1261 aacgagatca gtgttaattg tgtttcttga gcagctctcg tttgtttttc tcttttgtca
     1321 gcctcagcca tctgccatct tgatccctca gtctcacgtg gtgatatcta tctttctgtg
     1381 tgtgtgtgta tctctgtgtg tctctctgtg tcatctctct gtctctatgt gtctctgttc
     1441 ctctgtgtct tcctttgtcc tttgtgttct ctctctctct ctctctctct ctctctctct
     1501 ctctctctct ctctctccaa cttgcttcat gcttttctgg gcttgagtgt gcttaagaaa
     1561 acacatttta cgatcatcag aataaccccc cctttaaata aaaaactgtc ataatca
//
LOCUS       NM_001437882            3141 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 1, mRNA.
ACCESSION   NM_001437882 XM_063288186
VERSION     NM_001437882.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3141)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063288186.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.317170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000005.1  23661581-23661633
            54-140              JAXUCZ010000005.1  23666739-23666825
            141-319             JAXUCZ010000005.1  23676041-23676219
            320-3141            JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..3141
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3141
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..53
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            54..140
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            141..319
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            320..3141
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    515..517
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             635..1735
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001424811.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    671..988
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    671..988
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    1013..1084
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1121..1180
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1274..1393
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1334..1336
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1379..1705
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1379..1705
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1523..1525
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1571..1633
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 aggacctgca gctagctgcg ggggaggtca gtgaaggagt ctctcggttc acgatacctc
       61 ctgctgcaga gagcgcttta agcaaggaag gctttccttg gcttctgtct gcattccata
      121 aaatactcct tgccttttag gagattctga atacggatgc ttaatgtaat aaaccaagtg
      181 atagttacct catttcccga tctttagaaa gctttctgat tgctgattga tgacctgcac
      241 tggaatgcat gtggacctag gaaggaaact gaacattatc tcggaaagat gatttcattc
      301 ttgacgagcc agcacaaagc tctgcctgca gttgagcaca aagacctgaa ggagactccc
      361 acagccttca gggagaagaa aggaggcagc caaggctatt aaaaggaact tgtggcttgt
      421 ggcctttttg tgtaggagca gtctggaagg ggagaaaagt gcaccgaagc cacagtggcg
      481 gttaatgagc tgtgagatga ggcgcagccg cgactgacac tgcttccagg atccttcatc
      541 tgccctttgt gcttcgtgta catgtgtctg ttcaggccgg ccagaggcgc ccagaagagc
      601 atccaccacg gctgccgggg aaagaccgcc caccatgccc acggagacgc tacagacagg
      661 tagcatggtg aagcctgtca gccccgcggg caccttcacg tcggcggtgc ccctgcgcat
      721 cctgaacaaa ggacccgact acttccgcag gcaggctgag cccaacccca agagactcag
      781 tgcggtagag agactagagg ctgacaaggc caaatatgtc aagagccagg aagtgatcaa
      841 tgctaaacag gagccagtga agccggccgt gttggccaag ccccctgtgt gcccaggagc
      901 caaacgagta ctgggcagcc ccactctcaa ggtgttcggc aaccatgcca agaccgagag
      961 cggcgtgcaa cgcgagaccc tcaagcttga gatcctcaag aacatcatca acagctcaga
     1021 gggctccagc tctggctctg gccacaagca tagctcccga aactggccgc ctcacaggga
     1081 caccactgag ctgcaccggc attccttcgc agagtcgctg aaggtgtacc ctacacctgg
     1141 ccgtggcagc ccgcaggaga gcagctccca cgtgagcagg aggctgctgg agcagtctgc
     1201 ggagtccttc ctgcatgtct cacacagctc ctcagacatc cgcaaagtga ccagtgtgaa
     1261 gccccttaaa gccatcccct gcagcagttc tgcccctccc ctgcctccca agcccaaggt
     1321 ggctgctatg aagtcccctg atgctgacca ggtggaacca gcctgtgggg tcagccggag
     1381 accttccctt cagcggtcca agtcagactt gagtgacagg tatttccgag tagatgcaga
     1441 cgtggagagg ttcttcaact actgtggact tgacccagaa gagctggaaa accttggcat
     1501 ggagaacttt gccagggcta attctgacat catatctctc aacttccgca gtgcaagcat
     1561 gatcagctca gactgtgaac agtctcagga cagtaacagt gaccttagaa atgacgacag
     1621 tgccaatgac cgggtgccat acggcatttc tgccatcgag agaaatgcta gaatcatcaa
     1681 gtggctgtat agcatcaaac aagctagaga gtcacagaag gtgtcccacg tgtaagaggc
     1741 gcagtggtga aaaggagggg gggtgggtct gtctgtgcat acaccgttgt gaaggttgtg
     1801 aggtctcctt gaagtgtcgt gagcttctcc actttgtgtt gcttgttgtg caatgttctc
     1861 aagttgcatg cctgtcaaca tggcaactgg cctggcttcc ttctcacacc tcgcagggcc
     1921 ttgctgaaca ctcatctgcc aaaagttccc ggccagaatc tgattagggc tttgctctta
     1981 agcaaaactg tttacagaaa gaaaagaaaa gaaaaaaaaa aaaaaacggt ttcgatttct
     2041 tcaatattta tgtgtttttt gtgtttttat accctgcgct attgtgtctt aattaaaagt
     2101 tttatcaact ggcttttaag ttgagagcag aatctttttg aaacaaaaaa gccactttgc
     2161 ctacatggga gaccataaca ctggggaaat atatgggact tgccaccaaa tacagaatga
     2221 cagccaggct ggagttcatt tatgtgaaat caagtggtgg gccttgacct tgtgcttcac
     2281 atgttggcat tttcttgcca ctttgtgaag cactgtgggg caacagtaca gtcctcggtc
     2341 caattaagtg tatatgttgg tatttttgta gaactgaccc caggaaagac aatcagacaa
     2401 aacccaggat aggaggttct atattgattg ggaggggagg gaagggagac agttgatgct
     2461 gttcaaagtg ggataattca taaatatcta gtattaacct tacagaagtg ccattcgaca
     2521 gctgattaaa gctgatacag aatgctatct ttaaaacatt atttcgttgg attttatttg
     2581 ttttgtgctt ttggccaaga attaactcat gttgtttctc tcccttgctc ccttggtagt
     2641 tgttctgttc agggcggatg ggttggtctt ctgcaggttt gcactctgaa gggaggtgag
     2701 aataccatcc gtgtcagtat agtctccatt ccacagtatc cacgtgctgg ccgcttcaca
     2761 cctcagcagt gtgactctgt tacctcgctt atactcctct ctaaagccgt gggtatttgt
     2821 tagagctcta gaaaactgta gaaacaatat agctttccac tctgttgtct cttgttgcct
     2881 cttcccacaa tagcctgccc tccctcgggg tcatttcagg agctgtgagc cagctgccag
     2941 cgttggcaat ggacgaggag gacacgggtg ggctgctcca ctgcctcaca acccacaggt
     3001 tcgcagcaga agcacctcgg tcctcatcag ctactaggag ccttgaaacg gtgtgaatgc
     3061 tgtaagattc tgtacatact tgagttgttc tggaatctaa gaagaaagtt atgctaataa
     3121 atagctctgg tgtaggcttt a
//
LOCUS       NM_001437825            2402 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            4, mRNA.
ACCESSION   NM_001437825 XM_039112304
VERSION     NM_001437825.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2402)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2402)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039112304.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.1936.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105322162-105322211 c
            51-522              JAXUCZ010000001.1  105320341-105320812 c
            523-672             JAXUCZ010000001.1  105319532-105319681 c
            673-767             JAXUCZ010000001.1  105319331-105319425 c
            768-883             JAXUCZ010000001.1  105319133-105319248 c
            884-2402            JAXUCZ010000001.1  105317333-105318851 c
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2402
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..50
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..522
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    102..104
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             117..1967
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424754.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <570..1937
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <570..1937
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            523..672
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..767
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..883
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..2402
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagtgcag actctggagg ggctgccggg acgtcgcagc gtgcacgcag aggctggacc
       61 aggagctgac cacaagccaa gagtctagaa gtgcttggga ctgaaccaag gtcgtcatgg
      121 ccccaccacc actactgcca gtggctgcca gcactccgat cctgcacggc gagtttggtt
      181 cctacccagc ccatggcccc aggtttgccc tcaccctcac gacacaagcc ctacacatac
      241 agcgactgcg cccaaagcca gaagcccggc cccgagatgg tctagtccct ctggacgagg
      301 tctcaggctg tggcactctg cagagccgta gccccgaaga cactgcagcc tacttctgca
      361 tctacaccta cccacgtggc cggcgtgggg gccggcgcag agctactcgt accttccggg
      421 ccgacggggc cgccacttat gtggagaatc gtgcagaggc ccagcgttgg gcaactgctc
      481 tcatgtgtct cctccgagga gtgcctctgt ctggggacca ggaaatcacc cctgaattgc
      541 tgccccggaa gcccaggctg ctcctattgg tcaatccttt tggggggcgg ggcctggcct
      601 ggcagcgctg tatggaccac gtggtgccca tgatctctga agctgggctg tccttcaacc
      661 tcatacagac agaacgacaa aaccatgcac gtgagctggt gcaggggttg agcctgagtg
      721 agtgggaagg cattgtcact gtgtccggag atgggctgct ttatgaggtg ctgaatgggc
      781 tcctcgaccg cccagattgg gaagacgctg tgcggatgcc cattggtgtc ctcccctgtg
      841 gttcgggcaa tgcactagct ggggcagtta accatcatgg cgggtttgag caaactgttg
      901 gtgttgacct gttgctcaac tgctcgcttc ttctctgccg gggtggcagc catcctctgg
      961 acctgctctc tgtgacgcta gcctcaggat cccgctgttt ttccttcctg tcagttgcct
     1021 ggggattctt gtcagatgtg gacattcaca gcgagcgctt cagagccctg ggcagtgctc
     1081 gattcacact gggtgcagtg ctaggcctgg ccacattgca tacctaccgt ggacgtctct
     1141 cctacctccc tgctaccaca gaaccagcct tgcccatccc aggccatggt ctgccaagag
     1201 ccaagtcaga actagccttg gccccagccc cagccccagc cgccacccac tcacctcttc
     1261 atcgatctgt gtctgacctg cccctgcctc ttccccagcc tgccctggcc tcccctggct
     1321 cccctgagcc cctgcctgac ctgtccctca atggtggtgg tccagagctg actggagact
     1381 gggggggagc tggggatgca cctttgtccc cagacccatt gctgccttca tcccccaacg
     1441 ctttcaaaac agctcagctt tcacccatcg ccgaagggcc ctcagaaatg ccagcatcag
     1501 ggctgctgcc tcccatccac aatgctccag aagcctctac ctggggccca gcggaccacc
     1561 tgctccctcc cctgggctct ccactgcccc aagactgggt gacaatagag ggggagtttg
     1621 tactcatgtt ggccatcttg ccaagccacc tctgcgcaga cctgatggca gccccacacg
     1681 cgcgttttga cgatggtgtg gtgcacctgt gctgggtgcg gagcggcatc tcacgggccg
     1741 cacttctacg aattttgctg gccatggaac atggaaacca cttcagcctg ggctgcccac
     1801 atctgggcta tgctgcagca cgtgccttcc gccttgagcc actcacgcct cgtggggtgc
     1861 tcactgtaga tggggaatta gtagagtatg ggccaataca ggcacaggtg catccaagtc
     1921 tcgccacact gctcactggg cctgcaggtc aaaagcctcg agcctgaatg agcccaaagc
     1981 atgccaagtt gatgggacca gagccccata ggctaaggtc taccttttat aggtagaagt
     2041 ggggcctgaa ctcagaactg caagggtaga gagtgctcca gaccctcagt tcccagagga
     2101 ccctagaggc tcgagggtgg gatctgcctt tcttgatgtc caatgatggg gcctggaatg
     2161 tatgagctag caaggcttct tcagcttact gtccagtcag ggtttcttct tgcctatttc
     2221 ggtgcctcta cttgactggc caatcagccc ttgaggggca ggttccccca ggtggtccct
     2281 agatttgcac taatgttccc ctggccagtt aggggtggga tgttctgtgt cttgtgtgtc
     2341 cctgtcccta gtctaaaaag caattgaaaa ggtctatgca ataaaggtgt tgctttctct
     2401 gg
//
LOCUS       NM_001437884            2962 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 3, mRNA.
ACCESSION   NM_001437884 XM_006237839
VERSION     NM_001437884.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006237839.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.132988.1,
                                           SRR26360190.36827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000005.1  23661581-23661633
            54-140              JAXUCZ010000005.1  23666739-23666825
            141-2962            JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2962
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..53
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            54..140
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            141..2962
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    336..338
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             456..1556
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001424813.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    492..809
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    492..809
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    834..905
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    942..1001
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1095..1214
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1155..1157
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1200..1526
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1200..1526
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1344..1346
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1392..1454
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 aggacctgca gctagctgcg ggggaggtca gtgaaggagt ctctcggttc acgatacctc
       61 ctgctgcaga gagcgcttta agcaaggaag gctttccttg gcttctgtct gcattccata
      121 aaatactcct tgccttttag ctctgcctgc agttgagcac aaagacctga aggagactcc
      181 cacagccttc agggagaaga aaggaggcag ccaaggctat taaaaggaac ttgtggcttg
      241 tggccttttt gtgtaggagc agtctggaag gggagaaaag tgcaccgaag ccacagtggc
      301 ggttaatgag ctgtgagatg aggcgcagcc gcgactgaca ctgcttccag gatccttcat
      361 ctgccctttg tgcttcgtgt acatgtgtct gttcaggccg gccagaggcg cccagaagag
      421 catccaccac ggctgccggg gaaagaccgc ccaccatgcc cacggagacg ctacagacag
      481 gtagcatggt gaagcctgtc agccccgcgg gcaccttcac gtcggcggtg cccctgcgca
      541 tcctgaacaa aggacccgac tacttccgca ggcaggctga gcccaacccc aagagactca
      601 gtgcggtaga gagactagag gctgacaagg ccaaatatgt caagagccag gaagtgatca
      661 atgctaaaca ggagccagtg aagccggccg tgttggccaa gccccctgtg tgcccaggag
      721 ccaaacgagt actgggcagc cccactctca aggtgttcgg caaccatgcc aagaccgaga
      781 gcggcgtgca acgcgagacc ctcaagcttg agatcctcaa gaacatcatc aacagctcag
      841 agggctccag ctctggctct ggccacaagc atagctcccg aaactggccg cctcacaggg
      901 acaccactga gctgcaccgg cattccttcg cagagtcgct gaaggtgtac cctacacctg
      961 gccgtggcag cccgcaggag agcagctccc acgtgagcag gaggctgctg gagcagtctg
     1021 cggagtcctt cctgcatgtc tcacacagct cctcagacat ccgcaaagtg accagtgtga
     1081 agccccttaa agccatcccc tgcagcagtt ctgcccctcc cctgcctccc aagcccaagg
     1141 tggctgctat gaagtcccct gatgctgacc aggtggaacc agcctgtggg gtcagccgga
     1201 gaccttccct tcagcggtcc aagtcagact tgagtgacag gtatttccga gtagatgcag
     1261 acgtggagag gttcttcaac tactgtggac ttgacccaga agagctggaa aaccttggca
     1321 tggagaactt tgccagggct aattctgaca tcatatctct caacttccgc agtgcaagca
     1381 tgatcagctc agactgtgaa cagtctcagg acagtaacag tgaccttaga aatgacgaca
     1441 gtgccaatga ccgggtgcca tacggcattt ctgccatcga gagaaatgct agaatcatca
     1501 agtggctgta tagcatcaaa caagctagag agtcacagaa ggtgtcccac gtgtaagagg
     1561 cgcagtggtg aaaaggaggg ggggtgggtc tgtctgtgca tacaccgttg tgaaggttgt
     1621 gaggtctcct tgaagtgtcg tgagcttctc cactttgtgt tgcttgttgt gcaatgttct
     1681 caagttgcat gcctgtcaac atggcaactg gcctggcttc cttctcacac ctcgcagggc
     1741 cttgctgaac actcatctgc caaaagttcc cggccagaat ctgattaggg ctttgctctt
     1801 aagcaaaact gtttacagaa agaaaagaaa agaaaaaaaa aaaaaaacgg tttcgatttc
     1861 ttcaatattt atgtgttttt tgtgttttta taccctgcgc tattgtgtct taattaaaag
     1921 ttttatcaac tggcttttaa gttgagagca gaatcttttt gaaacaaaaa agccactttg
     1981 cctacatggg agaccataac actggggaaa tatatgggac ttgccaccaa atacagaatg
     2041 acagccaggc tggagttcat ttatgtgaaa tcaagtggtg ggccttgacc ttgtgcttca
     2101 catgttggca ttttcttgcc actttgtgaa gcactgtggg gcaacagtac agtcctcggt
     2161 ccaattaagt gtatatgttg gtatttttgt agaactgacc ccaggaaaga caatcagaca
     2221 aaacccagga taggaggttc tatattgatt gggaggggag ggaagggaga cagttgatgc
     2281 tgttcaaagt gggataattc ataaatatct agtattaacc ttacagaagt gccattcgac
     2341 agctgattaa agctgataca gaatgctatc tttaaaacat tatttcgttg gattttattt
     2401 gttttgtgct tttggccaag aattaactca tgttgtttct ctcccttgct cccttggtag
     2461 ttgttctgtt cagggcggat gggttggtct tctgcaggtt tgcactctga agggaggtga
     2521 gaataccatc cgtgtcagta tagtctccat tccacagtat ccacgtgctg gccgcttcac
     2581 acctcagcag tgtgactctg ttacctcgct tatactcctc tctaaagccg tgggtatttg
     2641 ttagagctct agaaaactgt agaaacaata tagctttcca ctctgttgtc tcttgttgcc
     2701 tcttcccaca atagcctgcc ctccctcggg gtcatttcag gagctgtgag ccagctgcca
     2761 gcgttggcaa tggacgagga ggacacgggt gggctgctcc actgcctcac aacccacagg
     2821 ttcgcagcag aagcacctcg gtcctcatca gctactagga gccttgaaac ggtgtgaatg
     2881 ctgtaagatt ctgtacatac ttgagttgtt ctggaatcta agaagaaagt tatgctaata
     2941 aatagctctg gtgtaggctt ta
//
LOCUS       NM_001437866            3601 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 17, mRNA.
ACCESSION   NM_001437866 XM_063273940
VERSION     NM_001437866.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3601)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3601)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3601)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3601)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3601)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3601)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3601)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3601)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3601)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3601)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063273940.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.610423.1,
                                           SRR26360194.480101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000015.1  3556246-3556469
            225-284             JAXUCZ010000015.1  3568253-3568312
            285-339             JAXUCZ010000015.1  3576050-3576104
            340-405             JAXUCZ010000015.1  3576930-3576995
            406-478             JAXUCZ010000015.1  3580329-3580401
            479-581             JAXUCZ010000015.1  3580559-3580661
            582-665             JAXUCZ010000015.1  3581097-3581180
            666-760             JAXUCZ010000015.1  3581604-3581698
            761-883             JAXUCZ010000015.1  3582328-3582450
            884-967             JAXUCZ010000015.1  3586196-3586279
            968-1010            JAXUCZ010000015.1  3586516-3586558
            1011-1054           JAXUCZ010000015.1  3590901-3590944
            1055-1123           JAXUCZ010000015.1  3600390-3600458
            1124-1168           JAXUCZ010000015.1  3601575-3601619
            1169-1217           JAXUCZ010000015.1  3604223-3604271
            1218-1293           JAXUCZ010000015.1  3607566-3607641
            1294-1388           JAXUCZ010000015.1  3607997-3608091
            1389-1633           JAXUCZ010000015.1  3609598-3609842
            1634-3601           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3601
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3601
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    179..181
                     /gene="Camk2g"
                     /note="upstream in-frame stop codon"
     CDS             185..1621
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 17 is encoded by transcript variant 17;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 17"
                     /protein_id="NP_001424795.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MHRKLNAEGWGPEDHQKLEREARICRLLKHPNIVRLHDSISEEG
                     FHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENL
                     LLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC
                     GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPA
                     KRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSA
                     AKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESC
                     NTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGM
                     DFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSE
                     ETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1220..1603
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1220..1603
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            225..284
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            285..339
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            340..405
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            406..478
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            479..581
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            666..760
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            761..883
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            884..967
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1010
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1054
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1123
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1168
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1217
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1293
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1388
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1633
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..3601
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagacatg ctctgactaa gaatggaaga ggcaggcagg aatgaggtga agatgggtct
       61 ctccctgtgc ccacacagcc tagccctggt gtagcagaaa tgtggctgac atctggtgtc
      121 tccagcggat ggtgcagctc cttgctttgc tcctcatcag tgcctactgg tccaggagtg
      181 agaaatgcat aggaagctga acgctgaagg ctggggacct gaagatcatc agaaactaga
      241 acgagaggcc cggatatgcc gacttctgaa acatccaaac atcgtgcgtc tccatgacag
      301 tatttctgaa gaagggtttc actacctcgt gtttgacctt gttacgggag gggagttgtt
      361 tgaagacatc gtggccagag aatactacag cgaagctgat gccagccact gtatacatca
      421 gatcctggag agcgtcaacc acatccacca gcatgacatc gtccaccggg acctgaagcc
      481 cgagaacttg ctgctggcga gtaaatgcaa gggtgctgcg gtcaagctag ctgattttgg
      541 cctggccatc gaagtgcagg gagagcagca ggcttggttt ggttttgctg gcaccccagg
      601 ttacttgtcc cctgaggtct tgaggaaaga tccctatgga aaacctgtgg atatctgggc
      661 ctgcggggtc atcctgtata tcctcctggt gggctaccct cccttctggg atgaggatca
      721 gcacaagctc tatcagcaga tcaaagctgg agcctacgat ttcccatcac cagaatggga
      781 cacagtcact cctgaagcta agaacttgat caaccagatg ttgaccataa accctgcaaa
      841 gcgtatcaca gctgaccagg ctctcaagca cccatgggtc tgtcaacggt caacagtggc
      901 atccatgatg catcgccaag agacagtgga gtgcttacgc aagttcaacg cccggagaaa
      961 actgaagggt gccatcctca caaccatgct tgtctccagg aacttttcag ctgccaagag
     1021 cctattgaac aagaagtcag atggcggcgt caagccacag agcaacaaca aaaacagtct
     1081 cgtaagccca gcccaagagc ccgcgccctt gcagacggcc atggagccac aaaccaccgt
     1141 ggtacataat gctacagatg ggatcaaggg ctccacagag agctgcaaca ccaccacaga
     1201 agacgaagat ctcaaagtgc gaaaacagga gatcattaag atcacagaac agctgataga
     1261 agccatcaac aatggggact ttgaggccta cacgaagatt tgtgacccag gcctcacttc
     1321 ctttgagcca gaagcccttg gtaacctcgt ggaggggatg gatttccata agttttactt
     1381 tgagaatctc ctgtccaaga acagcaagcc tatccacacc accatcctaa acccacatgt
     1441 ccatgtcatc ggcgaggacg cagcttgcat cgcctacatc cggctcaccc agtacatcga
     1501 tgggcagggt cggcctcgca ccagtcagtc agaggagacc cgggtgtggc accgccggga
     1561 tggcaagtgg ctcaatgtcc actatcactg ctcaggagcc cctgctgcac cgctgcagtg
     1621 agctcaggca caggggcatt aggagattcc agctggaggc tgaaccttcg aagtcagtga
     1681 ctctggaggg cctgagtgac agccgcggtc ctgtccattt gaggtttaaa acaattacat
     1741 tacaaagcgg cagcagccaa tgcacgcccc tgcatgcagc cctcccgccc gcccttcgtg
     1801 tctgtctctg ctgtactgag gtgtttttta catttaagaa aaaaaaaaga aaataagatt
     1861 gttttaaaaa aaaatggaat tcataccatg atgcgtttta aaacaactga tagcctttgg
     1921 gcttgaagaa ggcaggagtt tgtatgatgc tcatccaggc gtgaacagag ggctcaccca
     1981 ctggctttga agaggtgagc ttggcctcag gcccccatgg actcgggggg gaccaggcaa
     2041 ggactcttga cagagctttg gtcatggaca gagccatgct gtggttgcag ccccggtggt
     2101 gacctgatca ctccaggtct aggagtggac ttcttcagaa tatacattga cacctagtat
     2161 gagaaagaag aaaactccat ggctaacaga cctacttggg agagaacgca gcgctcccag
     2221 cccgctgtgg aggcaactgt gaagcgtggc ctcgggactg aaggcctgga ctttgccgta
     2281 ccgttccagt tagtgtagac aggaagagaa ttggtgctgc agaagtgtgt ccgacacaga
     2341 gccggtgtga aacctcgcgt tagtctgaca cgcacttact catccatttc tataggatgc
     2401 acaatgcacg tgggcctgag actgaggcct gatttctgca ggcgagaagg gggtgggatt
     2461 gctactttgt ttcctgttgg ttttcctaat gtatcaagga gagatccaga catcgttggc
     2521 cagggctcct gttgccactt tctgcagttg tgtttgtgtg cggatctgga ccactttgtc
     2581 ttatattttc gtggcggtgg tccccatgcc gaccctctgc caagtgcccc tgcgggatgg
     2641 gaggagtgag ataagagttg gtggttgttt ctatgcattc tggctgccct ctgggctgcc
     2701 tcccttcttc ccgtgctgca cgtccgtctc tttccctgag tttgagattg aaccgactgc
     2761 ttgggtgaga agtgtcctct ttaatgaggc tctctaccga ccaactgaag tatagacttt
     2821 tctgctggac aatctgcatg ggcatcaccc cctcacctgc atgtacccaa aaaggggtcc
     2881 agagccaagg ctcctgtagt cattgtccct ctctgtgctc aaggagttcc tttccaggag
     2941 gaaaagatct gtaccttagg cagataacag agaagacaat ggaggagcaa ttggtcatag
     3001 tcttggttcc ctcccaccca acagctgcac actatctgca ttttgggggg gaaggtgggt
     3061 tgacttcagc tctttggatg accttcaggg aggcacagga gctgggaaaa gatacagaac
     3121 tacagacttt ggaaccagct gagaagagaa caaactcatg ggtgctggtg cttgaattta
     3181 gccaggctcc tcaagcacct tgtgcatgcc tcagaccctg gaccctagcc ccttcctgcc
     3241 ctgcagcctg cagtgccagc caacagatcc cttcaccaca gggtttggtt ttgctggctt
     3301 gaagacaaca aatggtctta gagctcattg agacccatag cttcatatgg ctgctccagc
     3361 cccacttagc gttcttactc cacttctggg gctaatgtca gcatctatag acaattaata
     3421 gactatttaa aaaaaaaaac caccttttaa acaggaaatg aaaggcattt gatgcagaac
     3481 ttttgcatga cgacatagaa ataatttaaa aatagtgttt gttctgaatg ttggtagtcc
     3541 cttcatagct ttgttacaat gaaaccttga agatatttaa taaaataacc tttaaacagt
     3601 c
//
LOCUS       NM_133605               3633 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 10, mRNA.
ACCESSION   NM_133605
VERSION     NM_133605.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3633)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3633)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3633)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3633)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced NM_133605.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04063.1, SRR26360176.419335.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1155           JAXUCZ010000015.1  3598315-3598347
            1156-1200           JAXUCZ010000015.1  3601575-3601619
            1201-1249           JAXUCZ010000015.1  3604223-3604271
            1250-1325           JAXUCZ010000015.1  3607566-3607641
            1326-1420           JAXUCZ010000015.1  3607997-3608091
            1421-1665           JAXUCZ010000015.1  3609598-3609842
            1666-3633           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3633
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1653
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 10 is encoded by transcript variant 10;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 10"
                     /protein_id="NP_598289.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDL
                     KVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFEN
                     LLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRD
                     GKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    916..945
                     /gene="Camk2g"
                     /note="propagated from UniProtKB/Swiss-Prot (P11730.1);
                     Region: Autoinhibitory domain.
                     /evidence=ECO:0000250|UniProtKB:Q13555"
     misc_feature    928..930
                     /gene="Camk2g"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13555; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    949..1017
                     /gene="Camk2g"
                     /note="propagated from UniProtKB/Swiss-Prot (P11730.1);
                     Region: Calmodulin-binding.
                     /evidence=ECO:0000250|UniProtKB:Q13555"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    985..987
                     /gene="Camk2g"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    988..990
                     /gene="Camk2g"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1000..1002
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1030..1032
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1042..1044
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1054..1056
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1099..1236
                     /gene="Camk2g"
                     /note="propagated from UniProtKB/Swiss-Prot (P11730.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1132..1134
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     misc_feature    1252..1635
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1252..1635
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1426..1428
                     /gene="Camk2g"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11730.1); phosphorylation site"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1155
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1200
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1249
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1325
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1420
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1665
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..3633
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca agaaaaggaa gtcgagttcc
     1141 agcgtgcacc taatggagcc acaaaccacc gtggtacata atgctacaga tgggatcaag
     1201 ggctccacag agagctgcaa caccaccaca gaagacgaag atctcaaagt gcgaaaacag
     1261 gagatcatta agatcacaga acagctgata gaagccatca acaatgggga ctttgaggcc
     1321 tacacgaaga tttgtgaccc aggcctcact tcctttgagc cagaagccct tggtaacctc
     1381 gtggagggga tggatttcca taagttttac tttgagaatc tcctgtccaa gaacagcaag
     1441 cctatccaca ccaccatcct aaacccacat gtccatgtca tcggcgagga cgcagcttgc
     1501 atcgcctaca tccggctcac ccagtacatc gatgggcagg gtcggcctcg caccagtcag
     1561 tcagaggaga cccgggtgtg gcaccgccgg gatggcaagt ggctcaatgt ccactatcac
     1621 tgctcaggag cccctgctgc accgctgcag tgagctcagg cacaggggca ttaggagatt
     1681 ccagctggag gctgaacctt cgaagtcagt gactctggag ggcctgagtg acagccgcgg
     1741 tcctgtccat ttgaggttta aaacaattac attacaaagc ggcagcagcc aatgcacgcc
     1801 cctgcatgca gccctcccgc ccgcccttcg tgtctgtctc tgctgtactg aggtgttttt
     1861 tacatttaag aaaaaaaaaa gaaaataaga ttgttttaaa aaaaaatgga attcatacca
     1921 tgatgcgttt taaaacaact gatagccttt gggcttgaag aaggcaggag tttgtatgat
     1981 gctcatccag gcgtgaacag agggctcacc cactggcttt gaagaggtga gcttggcctc
     2041 aggcccccat ggactcgggg gggaccaggc aaggactctt gacagagctt tggtcatgga
     2101 cagagccatg ctgtggttgc agccccggtg gtgacctgat cactccaggt ctaggagtgg
     2161 acttcttcag aatatacatt gacacctagt atgagaaaga agaaaactcc atggctaaca
     2221 gacctacttg ggagagaacg cagcgctccc agcccgctgt ggaggcaact gtgaagcgtg
     2281 gcctcgggac tgaaggcctg gactttgccg taccgttcca gttagtgtag acaggaagag
     2341 aattggtgct gcagaagtgt gtccgacaca gagccggtgt gaaacctcgc gttagtctga
     2401 cacgcactta ctcatccatt tctataggat gcacaatgca cgtgggcctg agactgaggc
     2461 ctgatttctg caggcgagaa gggggtggga ttgctacttt gtttcctgtt ggttttccta
     2521 atgtatcaag gagagatcca gacatcgttg gccagggctc ctgttgccac tttctgcagt
     2581 tgtgtttgtg tgcggatctg gaccactttg tcttatattt tcgtggcggt ggtccccatg
     2641 ccgaccctct gccaagtgcc cctgcgggat gggaggagtg agataagagt tggtggttgt
     2701 ttctatgcat tctggctgcc ctctgggctg cctcccttct tcccgtgctg cacgtccgtc
     2761 tctttccctg agtttgagat tgaaccgact gcttgggtga gaagtgtcct ctttaatgag
     2821 gctctctacc gaccaactga agtatagact tttctgctgg acaatctgca tgggcatcac
     2881 cccctcacct gcatgtaccc aaaaaggggt ccagagccaa ggctcctgta gtcattgtcc
     2941 ctctctgtgc tcaaggagtt cctttccagg aggaaaagat ctgtacctta ggcagataac
     3001 agagaagaca atggaggagc aattggtcat agtcttggtt ccctcccacc caacagctgc
     3061 acactatctg cattttgggg gggaaggtgg gttgacttca gctctttgga tgaccttcag
     3121 ggaggcacag gagctgggaa aagatacaga actacagact ttggaaccag ctgagaagag
     3181 aacaaactca tgggtgctgg tgcttgaatt tagccaggct cctcaagcac cttgtgcatg
     3241 cctcagaccc tggaccctag ccccttcctg ccctgcagcc tgcagtgcca gccaacagat
     3301 cccttcacca cagggtttgg ttttgctggc ttgaagacaa caaatggtct tagagctcat
     3361 tgagacccat agcttcatat ggctgctcca gccccactta gcgttcttac tccacttctg
     3421 gggctaatgt cagcatctat agacaattaa tagactattt aaaaaaaaaa accacctttt
     3481 aaacaggaaa tgaaaggcat ttgatgcaga acttttgcat gacgacatag aaataattta
     3541 aaaatagtgt ttgttctgaa tgttggtagt cccttcatag ctttgttaca atgaaacctt
     3601 gaagatattt aataaaataa cctttaaaca gtc
//
LOCUS       NM_001437864            3537 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 15, mRNA.
ACCESSION   NM_001437864 XM_008770499
VERSION     NM_001437864.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3537)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3537)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3537)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3537)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3537)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3537)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3537)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770499.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.56072.1,
                                           SRR26360194.1394486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1104           JAXUCZ010000015.1  3601575-3601619
            1105-1153           JAXUCZ010000015.1  3604223-3604271
            1154-1229           JAXUCZ010000015.1  3607566-3607641
            1230-1324           JAXUCZ010000015.1  3607997-3608091
            1325-1569           JAXUCZ010000015.1  3609598-3609842
            1570-3537           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3537
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1557
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 15 is encoded by transcript variant 15;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 15"
                     /protein_id="NP_001424793.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKEPQT
                     TVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDP
                     GLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIR
                     LTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1156..1539
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1156..1539
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1104
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1153
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1324
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1569
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..3537
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaagg agccacaaac caccgtggta
     1081 cataatgcta cagatgggat caagggctcc acagagagct gcaacaccac cacagaagac
     1141 gaagatctca aagtgcgaaa acaggagatc attaagatca cagaacagct gatagaagcc
     1201 atcaacaatg gggactttga ggcctacacg aagatttgtg acccaggcct cacttccttt
     1261 gagccagaag cccttggtaa cctcgtggag gggatggatt tccataagtt ttactttgag
     1321 aatctcctgt ccaagaacag caagcctatc cacaccacca tcctaaaccc acatgtccat
     1381 gtcatcggcg aggacgcagc ttgcatcgcc tacatccggc tcacccagta catcgatggg
     1441 cagggtcggc ctcgcaccag tcagtcagag gagacccggg tgtggcaccg ccgggatggc
     1501 aagtggctca atgtccacta tcactgctca ggagcccctg ctgcaccgct gcagtgagct
     1561 caggcacagg ggcattagga gattccagct ggaggctgaa ccttcgaagt cagtgactct
     1621 ggagggcctg agtgacagcc gcggtcctgt ccatttgagg tttaaaacaa ttacattaca
     1681 aagcggcagc agccaatgca cgcccctgca tgcagccctc ccgcccgccc ttcgtgtctg
     1741 tctctgctgt actgaggtgt tttttacatt taagaaaaaa aaaagaaaat aagattgttt
     1801 taaaaaaaaa tggaattcat accatgatgc gttttaaaac aactgatagc ctttgggctt
     1861 gaagaaggca ggagtttgta tgatgctcat ccaggcgtga acagagggct cacccactgg
     1921 ctttgaagag gtgagcttgg cctcaggccc ccatggactc gggggggacc aggcaaggac
     1981 tcttgacaga gctttggtca tggacagagc catgctgtgg ttgcagcccc ggtggtgacc
     2041 tgatcactcc aggtctagga gtggacttct tcagaatata cattgacacc tagtatgaga
     2101 aagaagaaaa ctccatggct aacagaccta cttgggagag aacgcagcgc tcccagcccg
     2161 ctgtggaggc aactgtgaag cgtggcctcg ggactgaagg cctggacttt gccgtaccgt
     2221 tccagttagt gtagacagga agagaattgg tgctgcagaa gtgtgtccga cacagagccg
     2281 gtgtgaaacc tcgcgttagt ctgacacgca cttactcatc catttctata ggatgcacaa
     2341 tgcacgtggg cctgagactg aggcctgatt tctgcaggcg agaagggggt gggattgcta
     2401 ctttgtttcc tgttggtttt cctaatgtat caaggagaga tccagacatc gttggccagg
     2461 gctcctgttg ccactttctg cagttgtgtt tgtgtgcgga tctggaccac tttgtcttat
     2521 attttcgtgg cggtggtccc catgccgacc ctctgccaag tgcccctgcg ggatgggagg
     2581 agtgagataa gagttggtgg ttgtttctat gcattctggc tgccctctgg gctgcctccc
     2641 ttcttcccgt gctgcacgtc cgtctctttc cctgagtttg agattgaacc gactgcttgg
     2701 gtgagaagtg tcctctttaa tgaggctctc taccgaccaa ctgaagtata gacttttctg
     2761 ctggacaatc tgcatgggca tcaccccctc acctgcatgt acccaaaaag gggtccagag
     2821 ccaaggctcc tgtagtcatt gtccctctct gtgctcaagg agttcctttc caggaggaaa
     2881 agatctgtac cttaggcaga taacagagaa gacaatggag gagcaattgg tcatagtctt
     2941 ggttccctcc cacccaacag ctgcacacta tctgcatttt gggggggaag gtgggttgac
     3001 ttcagctctt tggatgacct tcagggaggc acaggagctg ggaaaagata cagaactaca
     3061 gactttggaa ccagctgaga agagaacaaa ctcatgggtg ctggtgcttg aatttagcca
     3121 ggctcctcaa gcaccttgtg catgcctcag accctggacc ctagcccctt cctgccctgc
     3181 agcctgcagt gccagccaac agatcccttc accacagggt ttggttttgc tggcttgaag
     3241 acaacaaatg gtcttagagc tcattgagac ccatagcttc atatggctgc tccagcccca
     3301 cttagcgttc ttactccact tctggggcta atgtcagcat ctatagacaa ttaatagact
     3361 atttaaaaaa aaaaaccacc ttttaaacag gaaatgaaag gcatttgatg cagaactttt
     3421 gcatgacgac atagaaataa tttaaaaata gtgtttgttc tgaatgttgg tagtcccttc
     3481 atagctttgt tacaatgaaa ccttgaagat atttaataaa ataaccttta aacagtc
//
LOCUS       NM_001437838            4104 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 7, mRNA.
ACCESSION   NM_001437838 XM_017590613
VERSION     NM_001437838.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4104)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4104)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4104)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4104)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4104)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4104)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4104)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4104)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4104)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017590613.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1438710.1,
                                           SRR26360194.1177318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1502           JAXUCZ010000002.1  217914468-217914509
            1503-1551           JAXUCZ010000002.1  217916935-217916983
            1552-1627           JAXUCZ010000002.1  217946550-217946625
            1628-1722           JAXUCZ010000002.1  217955065-217955159
            1723-1951           JAXUCZ010000002.1  217957098-217957326
            1952-4104           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4104
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..1955
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 7 is encoded by transcript variant 7;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 7"
                     /protein_id="NP_001424767.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPIN"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1371..1373
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1425..1541
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1509..1511
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1515..1517
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1527..1529
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1502
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1551
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1627
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1722
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1951
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..4104
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagccccaaa ctactgtaat ccacaaccct gatggaaaca
     1501 aggagtcaac tgagagctca aataccacca ttgaggatga agacgtgaaa gcacgaaagc
     1561 aagagatcat caaagtcact gagcagctga ttgaagctat caacaatggg gacttcgagg
     1621 cttacacgaa aatctgtgat ccaggcctca ctgcctttga acccgaagca ttgggcaact
     1681 tagtggaagg gatggacttt cacagattct actttgaaaa tgctttgccc aaaatcaata
     1741 aaccaatcca cactatcatc ctgaaccctc acgtacacct ggtaggggat gatgcagcct
     1801 gcatagcata cattcggctc acacagtaca tggatggaaa tggaatgcca aagacaatgc
     1861 agtcagaaga gactcgagtg tggcaccgcc gtgatgggaa gtggcagaat attcactttc
     1921 atcgttcggg gtccccaaca gtccccatca actaattgtc aacagtgcca cgtcttcatt
     1981 ctgtcctcaa ggcacctggc ggggtgatcc tgggacatcc tctcctcttc atgcatgttt
     2041 ctgagtgcat gaagttgtga aggttctacg tgtaatgcat atgtgacacg tcatcttacc
     2101 atgtgacacg ccatcttacc atgtattcct tcctgtacat tgtttacact ccagctactg
     2161 gacggatgtt ccatgcaaac gtcagttact gctggcaaac taaagaggga gctccgacaa
     2221 gaaaactccg caatactcca agttcagctg atccatcagg tttctctgtg gatgccaaga
     2281 ttcaaaagac ttcataaaat tactgttcaa tgaatgacag tgtgtaagag gaaaggaaat
     2341 ctttcaagaa tgctgccatt aatctatttg ggcttctcat tgggattttg gggttgattt
     2401 ttttttcatt ttttaaggca aatatatata tatatatata tatatatata tatatatata
     2461 tatatatata tatgccttca gttcctggta gaaatgaatg gatgcctttt ctctgaaagt
     2521 gttggtgttg gataaatgga tggctatgtg agccaagtcc tgggtgattg taggagcaag
     2581 aatcgtttgc tgttctacca tcaaagccat gttgatttgg gtcgagctct gtatactgga
     2641 aaaattcaca tcattttcta gtttgattgc tttcagatag gcacagttct ggtgaatgct
     2701 tggcactgat cttggttttt ctttcctaaa tctgtgttct gttttcatta tatactattt
     2761 gctcctttcc tttgtatttg ttttcttttc ccactctttt ctttatcttt ctctctccca
     2821 ctttctttct tttttatgtt ttcctttcta tagctgatag tgtgtaaaaa cagtaacatt
     2881 tgcatatgaa gttaaaataa aaatcaaggt cttctagaag ctaaaactag cacttccggt
     2941 ctctcacggg gctgtggagt tgttagaaga tttaaataaa tacttaaata agagaggaat
     3001 gaattcagct taggttacca cttgtgcata ggtatccttg ctctgttgaa agtgttggaa
     3061 ttgttgagac ttaagctaac agcagtaaga gcctgcttac acagtcctgg ttctccccaa
     3121 ctagatattg aagaccaagt ggagcctgac cagggttgca tgcagagcac ttgttttgga
     3181 ccttccagac taggaggcat ttactgcctc actttcacta gctagccaca ggaagagtgt
     3241 tctccatcct cctagaggtt gaacttgacc ttcgtgacta gtgcagttct agcttctctc
     3301 ttgagtcaca gtagcatcct gatgccagga gttaggcttt tgtccagatt aaaacaacga
     3361 ggaaaaggaa atgccccagt tttctttccg tttcccattt cttctttgtc gattcggtcc
     3421 ctgggagact gtttctccgc gctgaactgc tttatggtgc atggaatctc catcagcgta
     3481 cttctaccct agccactcac actccttaga agctgatttt taaagcagaa gcaaggaagc
     3541 aaaagtaaaa cactcccttc ccctcttttt cctcatttca ccttttggtg ttgattgcta
     3601 atcactttag atatattgtt gctagtgaat gtatgataga tgggttgaag cttttctgat
     3661 aattagcaca tgatttaaaa caatatatat ttaaaacaaa tatatacagt acatgtattg
     3721 agccgtgtta acctgccaat gagatctgtg aaaaacgtaa tggcctcact tttccctttg
     3781 aatttctttt acctttctgt gaagcagctc tgcgtggcat acatgtattt aaaaacacaa
     3841 atagtggtag aatgggtttt ttttttacac ttttaactta gcatgtggtg ttgaagtatt
     3901 accatagatc cagtttgtct tctgcactaa gatgtgagga aatcgtgatt tgttctctcc
     3961 agcacagtgg aattacacct tcatcatctt ctattgtttt gaaaacactg cagtttacca
     4021 tgggacactg tatataattc ttgccgtaat ggtaaatgac aaattgatat atttaagagt
     4081 taataaattt gtgatttctg ctga
//
LOCUS       NM_001437826            3265 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            5, mRNA.
ACCESSION   NM_001437826
VERSION     NM_001437826.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3265)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3265)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 3265)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 3265)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 3265)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 3265)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 3265)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 3265)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 3265)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 3265)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1740.1,
                                           SRR26360172.1433322.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               JAXUCZ010000001.1  105324149-105325054 c
            907-1378            JAXUCZ010000001.1  105320341-105320812 c
            1379-1528           JAXUCZ010000001.1  105319532-105319681 c
            1529-1623           JAXUCZ010000001.1  105319331-105319425 c
            1624-1739           JAXUCZ010000001.1  105319133-105319248 c
            1740-3265           JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..3265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3265
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..906
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1378
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    958..960
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             973..2823
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424755.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <1426..2793
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <1426..2793
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            1379..1528
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1623
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1739
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..3265
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggagg tgaggcttgt ccgggcctga agaaaaagct
      241 aatctcacac ttccggcact tccttaaatt cacggctgcc ttttccttat tctcagttta
      301 ctagacggaa ctgaaattca ggaagtccta ctagatctct tacccgagac tttcttgttg
      361 cggttcaacc catagtatca ttttttccca atattttgtg ttcagctttt tcccctgccc
      421 ctaaatgatc tcttcccgga tctctcctta gttttcttca ttagagacgg ctcctccctc
      481 cccccccaaa ccagactggt tgaaccggcc caacattttc gatgtactta ttgatgtgca
      541 gagaaggcac tcagagctcc cgtggctgga aagcggatag atagcaagct ctagagagaa
      601 tgaagtagag accatgacgg tggttggagg tgtggaggcc tgagggtgag aaggaaaaat
      661 ggtgagggaa acccaggcag aaggagagac aaagatacaa aaccgggcag ttggcaccta
      721 gccagatagt aagctacttc tggtgccagc tctacccacc ccccacccac ccccctttaa
      781 gtcaaggttt cacaaagttg cccagcctgg ctttgaccca gtcttcctgc ctcagcttcg
      841 gaagtaactg ggatcacagt ctttcaacac ttggcctggc tctgccattt aaaattgtga
      901 tcttggaggc tggaccagga gctgaccaca agccaagagt ctagaagtgc ttgggactga
      961 accaaggtcg tcatggcccc accaccacta ctgccagtgg ctgccagcac tccgatcctg
     1021 cacggcgagt ttggttccta cccagcccat ggccccaggt ttgccctcac cctcacgaca
     1081 caagccctac acatacagcg actgcgccca aagccagaag cccggccccg agatggtcta
     1141 gtccctctgg acgaggtctc aggctgtggc actctgcaga gccgtagccc cgaagacact
     1201 gcagcctact tctgcatcta cacctaccca cgtggccggc gtgggggccg gcgcagagct
     1261 actcgtacct tccgggccga cggggccgcc acttatgtgg agaatcgtgc agaggcccag
     1321 cgttgggcaa ctgctctcat gtgtctcctc cgaggagtgc ctctgtctgg ggaccaggaa
     1381 atcacccctg aattgctgcc ccggaagccc aggctgctcc tattggtcaa tccttttggg
     1441 gggcggggcc tggcctggca gcgctgtatg gaccacgtgg tgcccatgat ctctgaagct
     1501 gggctgtcct tcaacctcat acagacagaa cgacaaaacc atgcacgtga gctggtgcag
     1561 gggttgagcc tgagtgagtg ggaaggcatt gtcactgtgt ccggagatgg gctgctttat
     1621 gaggtgctga atgggctcct cgaccgccca gattgggaag acgctgtgcg gatgcccatt
     1681 ggtgtcctcc cctgtggttc gggcaatgca ctagctgggg cagttaacca tcatggcggg
     1741 tttgagcaaa ctgttggtgt tgacctgttg ctcaactgct cgcttcttct ctgccggggt
     1801 ggcagccatc ctctggacct gctctctgtg acgctagcct caggatcccg ctgtttttcc
     1861 ttcctgtcag ttgcctgggg attcttgtca gatgtggaca ttcacagcga gcgcttcaga
     1921 gccctgggca gtgctcgatt cacactgggt gcagtgctag gcctggccac attgcatacc
     1981 taccgtggac gtctctccta cctccctgct accacagaac cagccttgcc catcccaggc
     2041 catggtctgc caagagccaa gtcagaacta gccttggccc cagccccagc cccagccgcc
     2101 acccactcac ctcttcatcg atctgtgtct gacctgcccc tgcctcttcc ccagcctgcc
     2161 ctggcctccc ctggctcccc tgagcccctg cctgacctgt ccctcaatgg tggtggtcca
     2221 gagctgactg gagactgggg gggagctggg gatgcacctt tgtccccaga cccattgctg
     2281 ccttcatccc ccaacgcttt caaaacagct cagctttcac ccatcgccga agggccctca
     2341 gaaatgccag catcagggct gctgcctccc atccacaatg ctccagaagc ctctacctgg
     2401 ggcccagcgg accacctgct ccctcccctg ggctctccac tgccccaaga ctgggtgaca
     2461 atagaggggg agtttgtact catgttggcc atcttgccaa gccacctctg cgcagacctg
     2521 atggcagccc cacacgcgcg ttttgacgat ggtgtggtgc acctgtgctg ggtgcggagc
     2581 ggcatctcac gggccgcact tctacgaatt ttgctggcca tggaacatgg aaaccacttc
     2641 agcctgggct gcccacatct gggctatgct gcagcacgtg ccttccgcct tgagccactc
     2701 acgcctcgtg gggtgctcac tgtagatggg gaattagtag agtatgggcc aatacaggca
     2761 caggtgcatc caagtctcgc cacactgctc actgggcctg caggtcaaaa gcctcgagcc
     2821 tgaatgagcc caaagcatgc caagttgatg ggaccagagc cccataggct aaggtctacc
     2881 ttttataggt agaagtgggg cctgaactca gaactgcaag ggtagagagt gctccagacc
     2941 ctcagttccc agaggaccct agaggctcga gggtgggatc tgcctttctt gatgtccaat
     3001 gatggggcct ggaatgtatg agctagcaag gcttcttcag cttactgtcc agtcagggtt
     3061 tcttcttgcc tatttcggtg cctctacttg actggccaat cagcccttga ggggcaggtt
     3121 cccccaggtg gtccctagat ttgcactaat gttcccctgg ccagttaggg gtgggatgtt
     3181 ctgtgtcttg tgtgtccctg tccctagtct aaaaagcaat tgaaaaggtc tatgcaataa
     3241 aggtgttgct ttctctggac ctgca
//
LOCUS       NM_001437867            3532 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 18, mRNA.
ACCESSION   NM_001437867 XM_063273942
VERSION     NM_001437867.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3532)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3532)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3532)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3532)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3532)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3532)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3532)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3532)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3532)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3532)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063273942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.91706.1,
                                           SRR26360194.2136284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000015.1  3556246-3556469
            225-284             JAXUCZ010000015.1  3568253-3568312
            285-339             JAXUCZ010000015.1  3576050-3576104
            340-405             JAXUCZ010000015.1  3576930-3576995
            406-478             JAXUCZ010000015.1  3580329-3580401
            479-581             JAXUCZ010000015.1  3580559-3580661
            582-665             JAXUCZ010000015.1  3581097-3581180
            666-760             JAXUCZ010000015.1  3581604-3581698
            761-883             JAXUCZ010000015.1  3582328-3582450
            884-967             JAXUCZ010000015.1  3586196-3586279
            968-1010            JAXUCZ010000015.1  3586516-3586558
            1011-1054           JAXUCZ010000015.1  3590901-3590944
            1055-1099           JAXUCZ010000015.1  3601575-3601619
            1100-1148           JAXUCZ010000015.1  3604223-3604271
            1149-1224           JAXUCZ010000015.1  3607566-3607641
            1225-1319           JAXUCZ010000015.1  3607997-3608091
            1320-1564           JAXUCZ010000015.1  3609598-3609842
            1565-3532           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3532
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    179..181
                     /gene="Camk2g"
                     /note="upstream in-frame stop codon"
     CDS             185..1552
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 18 is encoded by transcript variant 18;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 18"
                     /protein_id="NP_001424796.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MHRKLNAEGWGPEDHQKLEREARICRLLKHPNIVRLHDSISEEG
                     FHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENL
                     LLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC
                     GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPA
                     KRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSA
                     AKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQL
                     IEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTIL
                     NPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAP
                     AAPLQ"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1151..1534
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1151..1534
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            225..284
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            285..339
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            340..405
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            406..478
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            479..581
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            666..760
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            761..883
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            884..967
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1010
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1054
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1099
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1148
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1319
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1564
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..3532
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagacatg ctctgactaa gaatggaaga ggcaggcagg aatgaggtga agatgggtct
       61 ctccctgtgc ccacacagcc tagccctggt gtagcagaaa tgtggctgac atctggtgtc
      121 tccagcggat ggtgcagctc cttgctttgc tcctcatcag tgcctactgg tccaggagtg
      181 agaaatgcat aggaagctga acgctgaagg ctggggacct gaagatcatc agaaactaga
      241 acgagaggcc cggatatgcc gacttctgaa acatccaaac atcgtgcgtc tccatgacag
      301 tatttctgaa gaagggtttc actacctcgt gtttgacctt gttacgggag gggagttgtt
      361 tgaagacatc gtggccagag aatactacag cgaagctgat gccagccact gtatacatca
      421 gatcctggag agcgtcaacc acatccacca gcatgacatc gtccaccggg acctgaagcc
      481 cgagaacttg ctgctggcga gtaaatgcaa gggtgctgcg gtcaagctag ctgattttgg
      541 cctggccatc gaagtgcagg gagagcagca ggcttggttt ggttttgctg gcaccccagg
      601 ttacttgtcc cctgaggtct tgaggaaaga tccctatgga aaacctgtgg atatctgggc
      661 ctgcggggtc atcctgtata tcctcctggt gggctaccct cccttctggg atgaggatca
      721 gcacaagctc tatcagcaga tcaaagctgg agcctacgat ttcccatcac cagaatggga
      781 cacagtcact cctgaagcta agaacttgat caaccagatg ttgaccataa accctgcaaa
      841 gcgtatcaca gctgaccagg ctctcaagca cccatgggtc tgtcaacggt caacagtggc
      901 atccatgatg catcgccaag agacagtgga gtgcttacgc aagttcaacg cccggagaaa
      961 actgaagggt gccatcctca caaccatgct tgtctccagg aacttttcag ctgccaagag
     1021 cctattgaac aagaagtcag atggcggcgt caaggagcca caaaccaccg tggtacataa
     1081 tgctacagat gggatcaagg gctccacaga gagctgcaac accaccacag aagacgaaga
     1141 tctcaaagtg cgaaaacagg agatcattaa gatcacagaa cagctgatag aagccatcaa
     1201 caatggggac tttgaggcct acacgaagat ttgtgaccca ggcctcactt cctttgagcc
     1261 agaagccctt ggtaacctcg tggaggggat ggatttccat aagttttact ttgagaatct
     1321 cctgtccaag aacagcaagc ctatccacac caccatccta aacccacatg tccatgtcat
     1381 cggcgaggac gcagcttgca tcgcctacat ccggctcacc cagtacatcg atgggcaggg
     1441 tcggcctcgc accagtcagt cagaggagac ccgggtgtgg caccgccggg atggcaagtg
     1501 gctcaatgtc cactatcact gctcaggagc ccctgctgca ccgctgcagt gagctcaggc
     1561 acaggggcat taggagattc cagctggagg ctgaaccttc gaagtcagtg actctggagg
     1621 gcctgagtga cagccgcggt cctgtccatt tgaggtttaa aacaattaca ttacaaagcg
     1681 gcagcagcca atgcacgccc ctgcatgcag ccctcccgcc cgcccttcgt gtctgtctct
     1741 gctgtactga ggtgtttttt acatttaaga aaaaaaaaag aaaataagat tgttttaaaa
     1801 aaaaatggaa ttcataccat gatgcgtttt aaaacaactg atagcctttg ggcttgaaga
     1861 aggcaggagt ttgtatgatg ctcatccagg cgtgaacaga gggctcaccc actggctttg
     1921 aagaggtgag cttggcctca ggcccccatg gactcggggg ggaccaggca aggactcttg
     1981 acagagcttt ggtcatggac agagccatgc tgtggttgca gccccggtgg tgacctgatc
     2041 actccaggtc taggagtgga cttcttcaga atatacattg acacctagta tgagaaagaa
     2101 gaaaactcca tggctaacag acctacttgg gagagaacgc agcgctccca gcccgctgtg
     2161 gaggcaactg tgaagcgtgg cctcgggact gaaggcctgg actttgccgt accgttccag
     2221 ttagtgtaga caggaagaga attggtgctg cagaagtgtg tccgacacag agccggtgtg
     2281 aaacctcgcg ttagtctgac acgcacttac tcatccattt ctataggatg cacaatgcac
     2341 gtgggcctga gactgaggcc tgatttctgc aggcgagaag ggggtgggat tgctactttg
     2401 tttcctgttg gttttcctaa tgtatcaagg agagatccag acatcgttgg ccagggctcc
     2461 tgttgccact ttctgcagtt gtgtttgtgt gcggatctgg accactttgt cttatatttt
     2521 cgtggcggtg gtccccatgc cgaccctctg ccaagtgccc ctgcgggatg ggaggagtga
     2581 gataagagtt ggtggttgtt tctatgcatt ctggctgccc tctgggctgc ctcccttctt
     2641 cccgtgctgc acgtccgtct ctttccctga gtttgagatt gaaccgactg cttgggtgag
     2701 aagtgtcctc tttaatgagg ctctctaccg accaactgaa gtatagactt ttctgctgga
     2761 caatctgcat gggcatcacc ccctcacctg catgtaccca aaaaggggtc cagagccaag
     2821 gctcctgtag tcattgtccc tctctgtgct caaggagttc ctttccagga ggaaaagatc
     2881 tgtaccttag gcagataaca gagaagacaa tggaggagca attggtcata gtcttggttc
     2941 cctcccaccc aacagctgca cactatctgc attttggggg ggaaggtggg ttgacttcag
     3001 ctctttggat gaccttcagg gaggcacagg agctgggaaa agatacagaa ctacagactt
     3061 tggaaccagc tgagaagaga acaaactcat gggtgctggt gcttgaattt agccaggctc
     3121 ctcaagcacc ttgtgcatgc ctcagaccct ggaccctagc cccttcctgc cctgcagcct
     3181 gcagtgccag ccaacagatc ccttcaccac agggtttggt tttgctggct tgaagacaac
     3241 aaatggtctt agagctcatt gagacccata gcttcatatg gctgctccag ccccacttag
     3301 cgttcttact ccacttctgg ggctaatgtc agcatctata gacaattaat agactattta
     3361 aaaaaaaaaa ccacctttta aacaggaaat gaaaggcatt tgatgcagaa cttttgcatg
     3421 acgacataga aataatttaa aaatagtgtt tgttctgaat gttggtagtc ccttcatagc
     3481 tttgttacaa tgaaaccttg aagatattta ataaaataac ctttaaacag tc
//
LOCUS       NM_021690               3430 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus Rap guanine nucleotide exchange factor 3
            (Rapgef3), transcript variant 2, mRNA.
ACCESSION   NM_021690
VERSION     NM_021690.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Boileve,A., Romito,O., Hof,T., Levallois,A., Brard,L., d'Hers,S.,
            Fouchet,A., Simard,C., Guinamard,R., Brette,F. and Salle,L.
  TITLE     EPAC1 and 2 inhibit K+ currents via PLC/PKC and NOS/PKG pathways in
            rat ventricular cardiomyocytes
  JOURNAL   Am J Physiol Cell Physiol 327 (3), C557-C570 (2024)
   PUBMED   38985989
  REMARK    GeneRIF: EPAC1 and 2 inhibit K[+] currents via PLC/PKC and NOS/PKG
            pathways in rat ventricular cardiomyocytes.
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Huang,S., Shi,C., Liu,F., Si,Y., Shen,D., Yang,L., Gao,Y. and
            Liao,Y.
  TITLE     Activation of Epac in the BLA disrupts reconsolidation and
            attenuates heroin-seeking behaviour
  JOURNAL   Addict Biol 28 (10), e13330 (2023)
   PUBMED   37753572
  REMARK    GeneRIF: Activation of Epac in the BLA disrupts reconsolidation and
            attenuates heroin-seeking behaviour.
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Sitzia,C., Vianello,E., Dozio,E., Kalousova,M., Zima,T.,
            Brizzola,S., Roccabianca,P., Tedeschi,G., Lamont,J., Tacchini,L.
            and Corsi-Romanelli,M.M.
  TITLE     Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to
            Obesity in Zucker Fatty Rats
  JOURNAL   Int J Mol Sci 24 (3), 1991 (2023)
   PUBMED   36768322
  REMARK    GeneRIF: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac
            Remodeling Due to Obesity in Zucker Fatty Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Huang,S.T., Chen,B.B., Song,Z.J., Tang,H.L., Hua,R. and Zhang,Y.M.
  TITLE     Unraveling the role of Epac1-SOCS3 signaling in the development of
            neonatal-CRD-induced visceral hypersensitivity in rats
  JOURNAL   CNS Neurosci Ther 28 (9), 1393-1408 (2022)
   PUBMED   35702948
  REMARK    GeneRIF: Unraveling the role of Epac1-SOCS3 signaling in the
            development of neonatal-CRD-induced visceral hypersensitivity in
            rats.
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Wang,X., Zhang,Y., Yang,Y., Zhang,W., Luo,L., Han,F., Guan,H.,
            Tao,K. and Hu,D.
  TITLE     Curcumin pretreatment protects against hypoxia/reoxgenation injury
            via improvement of mitochondrial function, destabilization of
            HIF-1alpha and activation of Epac1-Akt pathway in rat bone marrow
            mesenchymal stem cells
  JOURNAL   Biomed Pharmacother 109, 1268-1275 (2019)
   PUBMED   30551377
  REMARK    GeneRIF: Activation of Epac1-Akt signaling pathway.
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Weissman,J.T., Ma,J.N., Essex,A., Gao,Y. and Burstein,E.S.
  TITLE     G-protein-coupled receptor-mediated activation of rap GTPases:
            characterization of a novel Galphai regulated pathway
  JOURNAL   Oncogene 23 (1), 241-249 (2004)
   PUBMED   14712229
REFERENCE   7  (bases 1 to 3430)
  AUTHORS   Lin,S.L., Johnson-Farley,N.N., Lubinsky,D.R. and Cowen,D.S.
  TITLE     Coupling of neuronal 5-HT7 receptors to activation of
            extracellular-regulated kinase through a protein kinase
            A-independent pathway that can utilize Epac
  JOURNAL   J Neurochem 87 (5), 1076-1085 (2003)
   PUBMED   14622088
  REMARK    GeneRIF: Over-expression of Epac1 enhanced 5-HT7 nicotinic
            receptor-mediated activation of ERK proceeding through
            cAMP-dependent pathways utilizing cAMP-guanine nucleotide exchange
            factors rather than protein kinase A
REFERENCE   8  (bases 1 to 3430)
  AUTHORS   Laroche-Joubert,N., Marsy,S., Michelet,S., Imbert-Teboul,M. and
            Doucet,A.
  TITLE     Protein kinase A-independent activation of ERK and H,K-ATPase by
            cAMP in native kidney cells: role of Epac I
  JOURNAL   J Biol Chem 277 (21), 18598-18604 (2002)
   PUBMED   11897793
REFERENCE   9  (bases 1 to 3430)
  AUTHORS   Konu,O., Kane,J.K., Barrett,T., Vawter,M.P., Chang,R., Ma,J.Z.,
            Donovan,D.M., Sharp,B., Becker,K.G. and Li,M.D.
  TITLE     Region-specific transcriptional response to chronic nicotine in rat
            brain
  JOURNAL   Brain Res 909 (1-2), 194-203 (2001)
   PUBMED   11478936
REFERENCE   10 (bases 1 to 3430)
  AUTHORS   Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A family of cAMP-binding proteins that directly activate Rap1
  JOURNAL   Science 282 (5397), 2275-2279 (1998)
   PUBMED   9856955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced NM_021690.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107667.1, U78167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000007.1  130776528-130776828 c
            302-355             JAXUCZ010000007.1  130771083-130771136 c
            356-462             JAXUCZ010000007.1  130770888-130770994 c
            463-584             JAXUCZ010000007.1  130770593-130770714 c
            585-753             JAXUCZ010000007.1  130770050-130770218 c
            754-838             JAXUCZ010000007.1  130769409-130769493 c
            839-899             JAXUCZ010000007.1  130768674-130768734 c
            900-976             JAXUCZ010000007.1  130768511-130768587 c
            977-1123            JAXUCZ010000007.1  130768191-130768337 c
            1124-1236           JAXUCZ010000007.1  130767738-130767850 c
            1237-1325           JAXUCZ010000007.1  130767356-130767444 c
            1326-1404           JAXUCZ010000007.1  130767022-130767100 c
            1405-1564           JAXUCZ010000007.1  130766671-130766830 c
            1565-1647           JAXUCZ010000007.1  130766500-130766582 c
            1648-1687           JAXUCZ010000007.1  130765950-130765989 c
            1688-1769           JAXUCZ010000007.1  130763691-130763772 c
            1770-1916           JAXUCZ010000007.1  130763243-130763389 c
            1917-2014           JAXUCZ010000007.1  130760446-130760543 c
            2015-2140           JAXUCZ010000007.1  130759928-130760053 c
            2141-2322           JAXUCZ010000007.1  130759671-130759852 c
            2323-2413           JAXUCZ010000007.1  130759314-130759404 c
            2414-2464           JAXUCZ010000007.1  130759159-130759209 c
            2465-2552           JAXUCZ010000007.1  130758283-130758370 c
            2553-2617           JAXUCZ010000007.1  130757877-130757941 c
            2618-2672           JAXUCZ010000007.1  130757109-130757163 c
            2673-2744           JAXUCZ010000007.1  130756943-130757014 c
            2745-3430           JAXUCZ010000007.1  130754883-130755568 c
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3430
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Rap guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
     exon            1..301
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2863
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="isoform 2 is encoded by transcript variant 2; epac
                     1; cAMP-GEFI; exchange factor directly activated by cAMP
                     1; exchange protein directly activated by cAMP 1;
                     cAMP-regulated guanine nucleotide exchange factor I
                     (cAMP-GEFI); Rap guanine nucleotide exchange factor (GEF)
                     3"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     2"
                     /protein_id="NP_067722.2"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
                     /translation="MVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEGSLDFR
                     VSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGL
                     GVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELV
                     EAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAV
                     LLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVND
                     APRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPS
                     RPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQL
                     FAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSF
                     LQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWFPNHEEPL
                     PSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVN
                     SAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSA
                     KDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATE
                     LCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK
                     VRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLI
                     NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSP
                     ASTWAYVQQLKVIDNQRELSRLSRELEP"
     misc_feature    380..751
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     Region: DEP_Epac; cd04437"
                     /db_xref="CDD:239884"
     misc_feature    380..751
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     Region: DEP_Epac; cd04437"
                     /db_xref="CDD:239884"
     misc_feature    821..1150
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    821..1150
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(1013..1018,1043..1051)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(1013..1018,1043..1051)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(1112..1120,1130..1138)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(1112..1120,1130..1138)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    1241..1570
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="RasGEF N-terminal motif; Region: RasGEF_N;
                     pfam00618"
                     /db_xref="CDD:459873"
     misc_feature    1241..1570
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="RasGEF N-terminal motif; Region: RasGEF_N;
                     pfam00618"
                     /db_xref="CDD:459873"
     misc_feature    order(1289..1291,1466..1468,1478..1483,1490..1492,
                     1499..1504,1607..1612,1619..1621)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    order(1289..1291,1466..1468,1478..1483,1490..1492,
                     1499..1504,1607..1612,1619..1621)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    2063..2860
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; Region: RasGEF; smart00147"
                     /db_xref="CDD:214539"
     misc_feature    2063..2860
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; Region: RasGEF; smart00147"
                     /db_xref="CDD:214539"
     misc_feature    order(2162..2170,2201..2206,2210..2218,2222..2227,
                     2234..2239,2246..2248,2345..2347,2354..2359,2363..2371,
                     2375..2386,2390..2395,2453..2455,2462..2464,2477..2485,
                     2492..2494,2531..2539,2546..2554,2558..2566,2570..2581,
                     2621..2623,2633..2635,2738..2740,2747..2752)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
     misc_feature    order(2162..2170,2201..2206,2210..2218,2222..2227,
                     2234..2239,2246..2248,2345..2347,2354..2359,2363..2371,
                     2375..2386,2390..2395,2453..2455,2462..2464,2477..2485,
                     2492..2494,2531..2539,2546..2554,2558..2566,2570..2581,
                     2621..2623,2633..2635,2738..2740,2747..2752)
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
     exon            302..355
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            356..462
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            463..584
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            585..753
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            754..838
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            839..899
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            900..976
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1123
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1236
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1325
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1404
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1564
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1647
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1687
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1769
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1916
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2014
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2140
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2322
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2413
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2464
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2552
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2617
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2672
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2744
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..3430
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtccagag gacgctaagc ctggggtggt ggtaggaagg tccagctcct ccggccgatg
       61 gctgtccact ttcctccccc catcacaggt cagctggcca ggtgagaacc actggcaggt
      121 gggcccagct gtggtggaga gtccagctgt gggggcaccg caggtgggag gtctcccgga
      181 cgtggttccg gagggcacgc tgctcaatat ggtgctgaag agaatgcacc gtccccggtg
      241 ctgctcttac cagctagtgt tcgagcaccg gcgcccaagc tgcatccagg gacttcgctg
      301 gacgccactt accaacagtg agggctccct ggacttcaga gtgagcctgg agcaggccac
      361 cacagagcat gtgcacaagg ccgggaagct cctgtaccgt catctcttgg caacgtaccc
      421 taccctcatc cgagacagaa aataccatct gcgactacat cggcagtgct gctctggccg
      481 ggagctagtg gatgggatct tggctctggg tcttggggtc cactcacgga gccaagctgt
      541 gggcatctgc caggtgttgc tggatgaggg tgccctttgc catgtaaaac atgactggac
      601 cttccaggac cgagacgccc aattctacag attccctgga ccggagcccc agcctgcagg
      661 aactcatgac gtggaagagg agcttgttga ggcaatggcc ctactctccc agcgagggcc
      721 tgatgcccta ctcactgttg cactccggaa gtccccgggt cagcgtacag atgaagagct
      781 ggacctcatc ttcgaggagc tgctacatat caaggcggtg gctcaccttt ctaactcggt
      841 gaaacgggaa ctagctgctg ttctgctctt tgaaccacac agcaaggcag gaactgtgtt
      901 gttcagccag ggggacaagg gtacctcatg gtacattatc tggaagggat ctgtcaatgt
      961 ggtgacccat ggcaaggggc tggtgaccac gttgcacgag ggagatgact ttggacagct
     1021 ggctctggtg aacgacgcac ctcgagcagc caccatcatc cttcgagaaa ataactgtca
     1081 ctttctgcgt gtggacaagc aggacttcaa ccgcatcatc aaggatgtgg aagcaaaaac
     1141 catgagactg gaagaacacg gcaaagtggt gttagttttg gagagaacct ctcagggtgc
     1201 tggcccttcc cgccctccga ccccaggcag gaaccgatat acggtaatgt ctggcacccc
     1261 agagaaaatc ctagaactcc tgttggaggc tatgagaccg gattccagtg ctcatgaccc
     1321 aacagagaca ttcctcagtg acttcctgct gacgcacagt gtcttcatgc cctgcacaca
     1381 gctctttgcc gccctcctgc accacttcca cgtggagcca tcagagcctg ccgggggcag
     1441 cgagcaggaa cgcagcacct acatctgcaa caagaggcag cagattctgc gtctggtcag
     1501 ccggtgggtg gccctctaca gccccatgct ccgctcagat cccgtggcca ccagcttcct
     1561 ccagaaactc tcagacctgg tgagcagaga tacccgactt agcaacttgc tgagggaaca
     1621 gtatccggag agacggcgac accacaggtt ggagaatggc tgtgggaatg tatctcctca
     1681 gaccaaggcc cggaatgcac ctgtttggtt tcctaaccat gaggaacccc tcccaagcag
     1741 cgctggggcc atccgagtcg gggacaaagt cccctatgat atctgcagac ccgaccactc
     1801 ggtgctgacc ctgcacctgc cggtgacagc ctccgtgagg gaagtgatgg cagctttggc
     1861 ccatgaggac cactggacca aggggcaggt gctggtaaag gtcaattctg ccggtgatgt
     1921 cgttggcttg cagccagatg cccgcggtgt ggccacatcc ctggggctca atgagcggat
     1981 ctttgttgtc gacccacagg aagtgcacga gctgacccca caccctgagc agctggggcc
     2041 cactctgggt tcttctgaga tgctggacct agtgagtgcc aaggacctgg caggccagct
     2101 cacagagcat gactggaacc tcttcaacag gatccaccag gtggagctga tccactatgt
     2161 actgggcccc cagcacctgc gggacgtcac cactgcaaac ctggagcgct tcatgcgacg
     2221 cttcaacgag ctgcagtact gggtggccac cgaactctgt ctctgcccgg ttcctggccc
     2281 ccgggctcag ctactccgga agttcatcaa gctggcagcc cacctcaagg agcagaagaa
     2341 tctcaactct ttctttgcgg tcatgtttgg cctcagcaac tcggccatca gccgcctggc
     2401 ccacacctgg gagcgtctgc cccataaagt acggaagctg tactcggccc tggaaaggtt
     2461 gctggaccct tcctggaacc accgagtgta ccgattggct ctcaccaagc tctctcctcc
     2521 tgtcatccct ttcatgcccc tgctactcaa agacatgacc ttcatccatg aagggaacca
     2581 cacactggta gaaaacctca tcaactttga gaagatgcga atgatggcca gagccgtgcg
     2641 gatgctccac cactgccgaa gccacagcac cgcgcctcta tcaccactca gaagccgggt
     2701 ttcccacatc cacgaggaca gccaggcatc aagaatctcc acatgttccg agcagtccct
     2761 gagcacccgg agtccagcca gcacctgggc ttatgtccag cagctgaagg tcattgacaa
     2821 ccagcgggaa ctgtcccgcc tctcccggga actggaacca tgaggaagga ctggctggag
     2881 caggcacttc tctcagagaa agccagagcc tgtgcaacca agaggtccag aggccagcca
     2941 cagctgggca gggctctcca cagagcggac tcaaggccct ggagtgggca gtgtcgaggc
     3001 agctgtcctc tgtgatgact gtcagctgtg aagatctttg atgttcacgg ccaaggaaaa
     3061 ggggccattg aggccccaga ggggtaggag agctgggagg tgcaggactc tggttcagta
     3121 gagagccctc ccaccgggct ttctgcatgt ctgtatgtct gtacatgcag ctgtgctgtc
     3181 catggatgcc aggccctgtg cttgttttca caggagccag cgagctcaca tctgcatggg
     3241 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gagcactggg tggtgccttg
     3301 cctgggagag ggtggggagt tctgctattc tcaccacaca tctgagataa acagctgggt
     3361 gtgggcagag ccgctgccta gagtggtggt ccctgtggag ttgtattgtt cccataaatt
     3421 aacaaagata
//
LOCUS       NM_001437883            3046 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 2, mRNA.
ACCESSION   NM_001437883 XM_039110535
VERSION     NM_001437883.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3046)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039110535.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.425899.1,
                                           SRR21887620.199832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000005.1  23587082-23587218
            138-224             JAXUCZ010000005.1  23618556-23618642
            225-3046            JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..3046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3046
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..137
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            138..224
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            225..3046
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    420..422
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             540..1640
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001424812.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    576..893
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    576..893
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    918..989
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1026..1085
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1179..1298
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1239..1241
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1284..1610
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1284..1610
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1428..1430
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1476..1538
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 actccgagcc ggcggcgagg actcggcggc cacttcatcc tggcctgtag tgcctcgcgg
       61 tccccaagct cctcctcgcg gtctccgaag ccttgtgcct ggcctggacg ctttgcaggg
      121 accggagcgc gaccaagaaa tcccaacgca gacatcactc ctatcttttc tgagtcttga
      181 attgaaagct tcaaggactc tacagcctaa aagtgaaata aaagctctgc ctgcagttga
      241 gcacaaagac ctgaaggaga ctcccacagc cttcagggag aagaaaggag gcagccaagg
      301 ctattaaaag gaacttgtgg cttgtggcct ttttgtgtag gagcagtctg gaaggggaga
      361 aaagtgcacc gaagccacag tggcggttaa tgagctgtga gatgaggcgc agccgcgact
      421 gacactgctt ccaggatcct tcatctgccc tttgtgcttc gtgtacatgt gtctgttcag
      481 gccggccaga ggcgcccaga agagcatcca ccacggctgc cggggaaaga ccgcccacca
      541 tgcccacgga gacgctacag acaggtagca tggtgaagcc tgtcagcccc gcgggcacct
      601 tcacgtcggc ggtgcccctg cgcatcctga acaaaggacc cgactacttc cgcaggcagg
      661 ctgagcccaa ccccaagaga ctcagtgcgg tagagagact agaggctgac aaggccaaat
      721 atgtcaagag ccaggaagtg atcaatgcta aacaggagcc agtgaagccg gccgtgttgg
      781 ccaagccccc tgtgtgccca ggagccaaac gagtactggg cagccccact ctcaaggtgt
      841 tcggcaacca tgccaagacc gagagcggcg tgcaacgcga gaccctcaag cttgagatcc
      901 tcaagaacat catcaacagc tcagagggct ccagctctgg ctctggccac aagcatagct
      961 cccgaaactg gccgcctcac agggacacca ctgagctgca ccggcattcc ttcgcagagt
     1021 cgctgaaggt gtaccctaca cctggccgtg gcagcccgca ggagagcagc tcccacgtga
     1081 gcaggaggct gctggagcag tctgcggagt ccttcctgca tgtctcacac agctcctcag
     1141 acatccgcaa agtgaccagt gtgaagcccc ttaaagccat cccctgcagc agttctgccc
     1201 ctcccctgcc tcccaagccc aaggtggctg ctatgaagtc ccctgatgct gaccaggtgg
     1261 aaccagcctg tggggtcagc cggagacctt cccttcagcg gtccaagtca gacttgagtg
     1321 acaggtattt ccgagtagat gcagacgtgg agaggttctt caactactgt ggacttgacc
     1381 cagaagagct ggaaaacctt ggcatggaga actttgccag ggctaattct gacatcatat
     1441 ctctcaactt ccgcagtgca agcatgatca gctcagactg tgaacagtct caggacagta
     1501 acagtgacct tagaaatgac gacagtgcca atgaccgggt gccatacggc atttctgcca
     1561 tcgagagaaa tgctagaatc atcaagtggc tgtatagcat caaacaagct agagagtcac
     1621 agaaggtgtc ccacgtgtaa gaggcgcagt ggtgaaaagg agggggggtg ggtctgtctg
     1681 tgcatacacc gttgtgaagg ttgtgaggtc tccttgaagt gtcgtgagct tctccacttt
     1741 gtgttgcttg ttgtgcaatg ttctcaagtt gcatgcctgt caacatggca actggcctgg
     1801 cttccttctc acacctcgca gggccttgct gaacactcat ctgccaaaag ttcccggcca
     1861 gaatctgatt agggctttgc tcttaagcaa aactgtttac agaaagaaaa gaaaagaaaa
     1921 aaaaaaaaaa acggtttcga tttcttcaat atttatgtgt tttttgtgtt tttataccct
     1981 gcgctattgt gtcttaatta aaagttttat caactggctt ttaagttgag agcagaatct
     2041 ttttgaaaca aaaaagccac tttgcctaca tgggagacca taacactggg gaaatatatg
     2101 ggacttgcca ccaaatacag aatgacagcc aggctggagt tcatttatgt gaaatcaagt
     2161 ggtgggcctt gaccttgtgc ttcacatgtt ggcattttct tgccactttg tgaagcactg
     2221 tggggcaaca gtacagtcct cggtccaatt aagtgtatat gttggtattt ttgtagaact
     2281 gaccccagga aagacaatca gacaaaaccc aggataggag gttctatatt gattgggagg
     2341 ggagggaagg gagacagttg atgctgttca aagtgggata attcataaat atctagtatt
     2401 aaccttacag aagtgccatt cgacagctga ttaaagctga tacagaatgc tatctttaaa
     2461 acattatttc gttggatttt atttgttttg tgcttttggc caagaattaa ctcatgttgt
     2521 ttctctccct tgctcccttg gtagttgttc tgttcagggc ggatgggttg gtcttctgca
     2581 ggtttgcact ctgaagggag gtgagaatac catccgtgtc agtatagtct ccattccaca
     2641 gtatccacgt gctggccgct tcacacctca gcagtgtgac tctgttacct cgcttatact
     2701 cctctctaaa gccgtgggta tttgttagag ctctagaaaa ctgtagaaac aatatagctt
     2761 tccactctgt tgtctcttgt tgcctcttcc cacaatagcc tgccctccct cggggtcatt
     2821 tcaggagctg tgagccagct gccagcgttg gcaatggacg aggaggacac gggtgggctg
     2881 ctccactgcc tcacaaccca caggttcgca gcagaagcac ctcggtcctc atcagctact
     2941 aggagccttg aaacggtgtg aatgctgtaa gattctgtac atacttgagt tgttctggaa
     3001 tctaagaaga aagttatgct aataaatagc tctggtgtag gcttta
//
LOCUS       NM_001437865            3646 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 16, mRNA.
ACCESSION   NM_001437865 XM_063273939
VERSION     NM_001437865.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3646)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3646)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3646)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3646)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3646)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3646)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3646)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3646)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3646)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3646)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063273939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.440842.1,
                                           SRR26643298.56253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000015.1  3556246-3556469
            225-284             JAXUCZ010000015.1  3568253-3568312
            285-339             JAXUCZ010000015.1  3576050-3576104
            340-405             JAXUCZ010000015.1  3576930-3576995
            406-478             JAXUCZ010000015.1  3580329-3580401
            479-581             JAXUCZ010000015.1  3580559-3580661
            582-665             JAXUCZ010000015.1  3581097-3581180
            666-760             JAXUCZ010000015.1  3581604-3581698
            761-883             JAXUCZ010000015.1  3582328-3582450
            884-967             JAXUCZ010000015.1  3586196-3586279
            968-1010            JAXUCZ010000015.1  3586516-3586558
            1011-1054           JAXUCZ010000015.1  3590901-3590944
            1055-1099           JAXUCZ010000015.1  3601575-3601619
            1100-1148           JAXUCZ010000015.1  3604223-3604271
            1149-1262           JAXUCZ010000015.1  3605519-3605632
            1263-1338           JAXUCZ010000015.1  3607566-3607641
            1339-1433           JAXUCZ010000015.1  3607997-3608091
            1434-1678           JAXUCZ010000015.1  3609598-3609842
            1679-3646           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3646
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    179..181
                     /gene="Camk2g"
                     /note="upstream in-frame stop codon"
     CDS             185..1666
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 16 is encoded by transcript variant 16;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 16"
                     /protein_id="NP_001424794.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MHRKLNAEGWGPEDHQKLEREARICRLLKHPNIVRLHDSISEEG
                     FHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENL
                     LLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC
                     GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPA
                     KRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSA
                     AKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSLVP
                     EGRSPRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGL
                     TSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLT
                     QYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    191..973
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(353..355,359..361,467..472,476..478,482..484,
                     542..544,587..601,605..607)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(530..562,569..601)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(944..946,950..973)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1265..1648
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1265..1648
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            225..284
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            285..339
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            340..405
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            406..478
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            479..581
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            666..760
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            761..883
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            884..967
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1010
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1054
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1099
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1148
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1262
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1338
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1433
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1678
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..3646
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagacatg ctctgactaa gaatggaaga ggcaggcagg aatgaggtga agatgggtct
       61 ctccctgtgc ccacacagcc tagccctggt gtagcagaaa tgtggctgac atctggtgtc
      121 tccagcggat ggtgcagctc cttgctttgc tcctcatcag tgcctactgg tccaggagtg
      181 agaaatgcat aggaagctga acgctgaagg ctggggacct gaagatcatc agaaactaga
      241 acgagaggcc cggatatgcc gacttctgaa acatccaaac atcgtgcgtc tccatgacag
      301 tatttctgaa gaagggtttc actacctcgt gtttgacctt gttacgggag gggagttgtt
      361 tgaagacatc gtggccagag aatactacag cgaagctgat gccagccact gtatacatca
      421 gatcctggag agcgtcaacc acatccacca gcatgacatc gtccaccggg acctgaagcc
      481 cgagaacttg ctgctggcga gtaaatgcaa gggtgctgcg gtcaagctag ctgattttgg
      541 cctggccatc gaagtgcagg gagagcagca ggcttggttt ggttttgctg gcaccccagg
      601 ttacttgtcc cctgaggtct tgaggaaaga tccctatgga aaacctgtgg atatctgggc
      661 ctgcggggtc atcctgtata tcctcctggt gggctaccct cccttctggg atgaggatca
      721 gcacaagctc tatcagcaga tcaaagctgg agcctacgat ttcccatcac cagaatggga
      781 cacagtcact cctgaagcta agaacttgat caaccagatg ttgaccataa accctgcaaa
      841 gcgtatcaca gctgaccagg ctctcaagca cccatgggtc tgtcaacggt caacagtggc
      901 atccatgatg catcgccaag agacagtgga gtgcttacgc aagttcaacg cccggagaaa
      961 actgaagggt gccatcctca caaccatgct tgtctccagg aacttttcag ctgccaagag
     1021 cctattgaac aagaagtcag atggcggcgt caaggagcca caaaccaccg tggtacataa
     1081 tgctacagat gggatcaagg gctccacaga gagctgcaac accaccacag aagacgaaga
     1141 tctcaaagct gccccgctcc gcactgggaa tggcagcttg gtgcctgaag gacggagccc
     1201 ccgggacaga acagccccct ctgcaggcat gcagccccag ccttctctct gctcctcagc
     1261 catgcgaaaa caggagatca ttaagatcac agaacagctg atagaagcca tcaacaatgg
     1321 ggactttgag gcctacacga agatttgtga cccaggcctc acttcctttg agccagaagc
     1381 ccttggtaac ctcgtggagg ggatggattt ccataagttt tactttgaga atctcctgtc
     1441 caagaacagc aagcctatcc acaccaccat cctaaaccca catgtccatg tcatcggcga
     1501 ggacgcagct tgcatcgcct acatccggct cacccagtac atcgatgggc agggtcggcc
     1561 tcgcaccagt cagtcagagg agacccgggt gtggcaccgc cgggatggca agtggctcaa
     1621 tgtccactat cactgctcag gagcccctgc tgcaccgctg cagtgagctc aggcacaggg
     1681 gcattaggag attccagctg gaggctgaac cttcgaagtc agtgactctg gagggcctga
     1741 gtgacagccg cggtcctgtc catttgaggt ttaaaacaat tacattacaa agcggcagca
     1801 gccaatgcac gcccctgcat gcagccctcc cgcccgccct tcgtgtctgt ctctgctgta
     1861 ctgaggtgtt ttttacattt aagaaaaaaa aaagaaaata agattgtttt aaaaaaaaat
     1921 ggaattcata ccatgatgcg ttttaaaaca actgatagcc tttgggcttg aagaaggcag
     1981 gagtttgtat gatgctcatc caggcgtgaa cagagggctc acccactggc tttgaagagg
     2041 tgagcttggc ctcaggcccc catggactcg ggggggacca ggcaaggact cttgacagag
     2101 ctttggtcat ggacagagcc atgctgtggt tgcagccccg gtggtgacct gatcactcca
     2161 ggtctaggag tggacttctt cagaatatac attgacacct agtatgagaa agaagaaaac
     2221 tccatggcta acagacctac ttgggagaga acgcagcgct cccagcccgc tgtggaggca
     2281 actgtgaagc gtggcctcgg gactgaaggc ctggactttg ccgtaccgtt ccagttagtg
     2341 tagacaggaa gagaattggt gctgcagaag tgtgtccgac acagagccgg tgtgaaacct
     2401 cgcgttagtc tgacacgcac ttactcatcc atttctatag gatgcacaat gcacgtgggc
     2461 ctgagactga ggcctgattt ctgcaggcga gaagggggtg ggattgctac tttgtttcct
     2521 gttggttttc ctaatgtatc aaggagagat ccagacatcg ttggccaggg ctcctgttgc
     2581 cactttctgc agttgtgttt gtgtgcggat ctggaccact ttgtcttata ttttcgtggc
     2641 ggtggtcccc atgccgaccc tctgccaagt gcccctgcgg gatgggagga gtgagataag
     2701 agttggtggt tgtttctatg cattctggct gccctctggg ctgcctccct tcttcccgtg
     2761 ctgcacgtcc gtctctttcc ctgagtttga gattgaaccg actgcttggg tgagaagtgt
     2821 cctctttaat gaggctctct accgaccaac tgaagtatag acttttctgc tggacaatct
     2881 gcatgggcat caccccctca cctgcatgta cccaaaaagg ggtccagagc caaggctcct
     2941 gtagtcattg tccctctctg tgctcaagga gttcctttcc aggaggaaaa gatctgtacc
     3001 ttaggcagat aacagagaag acaatggagg agcaattggt catagtcttg gttccctccc
     3061 acccaacagc tgcacactat ctgcattttg ggggggaagg tgggttgact tcagctcttt
     3121 ggatgacctt cagggaggca caggagctgg gaaaagatac agaactacag actttggaac
     3181 cagctgagaa gagaacaaac tcatgggtgc tggtgcttga atttagccag gctcctcaag
     3241 caccttgtgc atgcctcaga ccctggaccc tagccccttc ctgccctgca gcctgcagtg
     3301 ccagccaaca gatcccttca ccacagggtt tggttttgct ggcttgaaga caacaaatgg
     3361 tcttagagct cattgagacc catagcttca tatggctgct ccagccccac ttagcgttct
     3421 tactccactt ctggggctaa tgtcagcatc tatagacaat taatagacta tttaaaaaaa
     3481 aaaaccacct tttaaacagg aaatgaaagg catttgatgc agaacttttg catgacgaca
     3541 tagaaataat ttaaaaatag tgtttgttct gaatgttggt agtcccttca tagctttgtt
     3601 acaatgaaac cttgaagata tttaataaaa taacctttaa acagtc
//
LOCUS       NM_001437859            3639 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 9, mRNA.
ACCESSION   NM_001437859 XM_008770496
VERSION     NM_001437859.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3639)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3639)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3639)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3639)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770496.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.56238.1,
                                           SRR26643296.33849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1092           JAXUCZ010000015.1  3598315-3598347
            1093-1161           JAXUCZ010000015.1  3600390-3600458
            1162-1206           JAXUCZ010000015.1  3601575-3601619
            1207-1255           JAXUCZ010000015.1  3604223-3604271
            1256-1331           JAXUCZ010000015.1  3607566-3607641
            1332-1426           JAXUCZ010000015.1  3607997-3608091
            1427-1671           JAXUCZ010000015.1  3609598-3609842
            1672-3639           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3639
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1659
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 9 is encoded by transcript variant 9;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 9"
                     /protein_id="NP_001424788.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKS
                     SSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDE
                     DLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYF
                     ENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHR
                     RDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1258..1641
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1258..1641
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1092
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1161
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1206
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1255
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1331
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1426
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1671
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..3639
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaaga aaaggaagtc gagttccagc
     1081 gtgcacctaa tgccacagag caacaacaaa aacagtctcg taagcccagc ccaagagccc
     1141 gcgcccttgc agacggccat ggagccacaa accaccgtgg tacataatgc tacagatggg
     1201 atcaagggct ccacagagag ctgcaacacc accacagaag acgaagatct caaagtgcga
     1261 aaacaggaga tcattaagat cacagaacag ctgatagaag ccatcaacaa tggggacttt
     1321 gaggcctaca cgaagatttg tgacccaggc ctcacttcct ttgagccaga agcccttggt
     1381 aacctcgtgg aggggatgga tttccataag ttttactttg agaatctcct gtccaagaac
     1441 agcaagccta tccacaccac catcctaaac ccacatgtcc atgtcatcgg cgaggacgca
     1501 gcttgcatcg cctacatccg gctcacccag tacatcgatg ggcagggtcg gcctcgcacc
     1561 agtcagtcag aggagacccg ggtgtggcac cgccgggatg gcaagtggct caatgtccac
     1621 tatcactgct caggagcccc tgctgcaccg ctgcagtgag ctcaggcaca ggggcattag
     1681 gagattccag ctggaggctg aaccttcgaa gtcagtgact ctggagggcc tgagtgacag
     1741 ccgcggtcct gtccatttga ggtttaaaac aattacatta caaagcggca gcagccaatg
     1801 cacgcccctg catgcagccc tcccgcccgc ccttcgtgtc tgtctctgct gtactgaggt
     1861 gttttttaca tttaagaaaa aaaaaagaaa ataagattgt tttaaaaaaa aatggaattc
     1921 ataccatgat gcgttttaaa acaactgata gcctttgggc ttgaagaagg caggagtttg
     1981 tatgatgctc atccaggcgt gaacagaggg ctcacccact ggctttgaag aggtgagctt
     2041 ggcctcaggc ccccatggac tcggggggga ccaggcaagg actcttgaca gagctttggt
     2101 catggacaga gccatgctgt ggttgcagcc ccggtggtga cctgatcact ccaggtctag
     2161 gagtggactt cttcagaata tacattgaca cctagtatga gaaagaagaa aactccatgg
     2221 ctaacagacc tacttgggag agaacgcagc gctcccagcc cgctgtggag gcaactgtga
     2281 agcgtggcct cgggactgaa ggcctggact ttgccgtacc gttccagtta gtgtagacag
     2341 gaagagaatt ggtgctgcag aagtgtgtcc gacacagagc cggtgtgaaa cctcgcgtta
     2401 gtctgacacg cacttactca tccatttcta taggatgcac aatgcacgtg ggcctgagac
     2461 tgaggcctga tttctgcagg cgagaagggg gtgggattgc tactttgttt cctgttggtt
     2521 ttcctaatgt atcaaggaga gatccagaca tcgttggcca gggctcctgt tgccactttc
     2581 tgcagttgtg tttgtgtgcg gatctggacc actttgtctt atattttcgt ggcggtggtc
     2641 cccatgccga ccctctgcca agtgcccctg cgggatggga ggagtgagat aagagttggt
     2701 ggttgtttct atgcattctg gctgccctct gggctgcctc ccttcttccc gtgctgcacg
     2761 tccgtctctt tccctgagtt tgagattgaa ccgactgctt gggtgagaag tgtcctcttt
     2821 aatgaggctc tctaccgacc aactgaagta tagacttttc tgctggacaa tctgcatggg
     2881 catcaccccc tcacctgcat gtacccaaaa aggggtccag agccaaggct cctgtagtca
     2941 ttgtccctct ctgtgctcaa ggagttcctt tccaggagga aaagatctgt accttaggca
     3001 gataacagag aagacaatgg aggagcaatt ggtcatagtc ttggttccct cccacccaac
     3061 agctgcacac tatctgcatt ttggggggga aggtgggttg acttcagctc tttggatgac
     3121 cttcagggag gcacaggagc tgggaaaaga tacagaacta cagactttgg aaccagctga
     3181 gaagagaaca aactcatggg tgctggtgct tgaatttagc caggctcctc aagcaccttg
     3241 tgcatgcctc agaccctgga ccctagcccc ttcctgccct gcagcctgca gtgccagcca
     3301 acagatccct tcaccacagg gtttggtttt gctggcttga agacaacaaa tggtcttaga
     3361 gctcattgag acccatagct tcatatggct gctccagccc cacttagcgt tcttactcca
     3421 cttctggggc taatgtcagc atctatagac aattaataga ctatttaaaa aaaaaaacca
     3481 ccttttaaac aggaaatgaa aggcatttga tgcagaactt ttgcatgacg acatagaaat
     3541 aatttaaaaa tagtgtttgt tctgaatgtt ggtagtccct tcatagcttt gttacaatga
     3601 aaccttgaag atatttaata aaataacctt taaacagtc
//
LOCUS       NM_001437818            1886 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus sulfide quinone oxidoreductase (Sqor), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437818 XM_039105892
VERSION     NM_001437818.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Augustyn,K.D., Jackson,M.R. and Jorns,M.S.
  TITLE     Use of Tissue Metabolite Analysis and Enzyme Kinetics To
            Discriminate between Alternate Pathways for Hydrogen Sulfide
            Metabolism
  JOURNAL   Biochemistry 56 (7), 986-996 (2017)
   PUBMED   28107627
  REMARK    GeneRIF: The role of Sqor in hydrogen sulfide metabolism in the
            heart and liver
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Ackermann,M., Kubitza,M., Hauska,G. and Pina,A.L.
  TITLE     The vertebrate homologue of sulfide-quinone reductase in mammalian
            mitochondria
  JOURNAL   Cell Tissue Res 358 (3), 779-792 (2014)
   PUBMED   25130143
  REMARK    GeneRIF: The present report demonstrates the presence and specific
            localization of SQRDL in various mammalian tissues.
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Jackson,M.R., Melideo,S.L. and Jorns,M.S.
  TITLE     Human sulfide:quinone oxidoreductase catalyzes the first step in
            hydrogen sulfide metabolism and produces a sulfane sulfur
            metabolite
  JOURNAL   Biochemistry 51 (34), 6804-6815 (2012)
   PUBMED   22852582
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Ackermann,M., Kubitza,M., Maier,K., Brawanski,A., Hauska,G. and
            Pina,A.L.
  TITLE     The vertebrate homolog of sulfide-quinone reductase is expressed in
            mitochondria of neuronal tissues
  JOURNAL   Neuroscience 199, 1-12 (2011)
   PUBMED   22067608
  REMARK    GeneRIF: we demonstrated that the SQRDL protein is expressed in
            neurons, oligodendrocytes, and endothelial cells
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1886)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039105892.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.14919.1,
                                           SRR26643296.11274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000003.1  130294885-130294935
            52-302              JAXUCZ010000003.1  130318361-130318611
            303-473             JAXUCZ010000003.1  130320797-130320967
            474-527             JAXUCZ010000003.1  130325592-130325645
            528-722             JAXUCZ010000003.1  130330300-130330494
            723-932             JAXUCZ010000003.1  130331246-130331455
            933-1116            JAXUCZ010000003.1  130335284-130335467
            1117-1184           JAXUCZ010000003.1  130337368-130337435
            1185-1363           JAXUCZ010000003.1  130337681-130337859
            1364-1886           JAXUCZ010000003.1  130340280-130340802
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1886
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="sulfide quinone oxidoreductase"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
     exon            1..51
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            52..302
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    54..56
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="upstream in-frame stop codon"
     CDS             69..1376
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /EC_number="1.8.5.8"
                     /note="isoform 2 is encoded by transcript variant 3;
                     sulfide:quinone oxidoreductase, mitochondrial"
                     /codon_start=1
                     /product="sulfide:quinone oxidoreductase, mitochondrial
                     isoform 2"
                     /protein_id="NP_001424747.1"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
                     /translation="MAPLVAVVSSPRARLFACFLRLGTQQAGPLQLHTGACCTAKNHY
                     EVLVLGGGSGGITMATRMKRRVGAENVAIVEPSERHFYQPIWTLVGAGAKELSSSDRS
                     TLSVIPSGVQWIQDRVAELNPDQNCIRTDNGKEISYRYLIIALGIQLDYEKIKGLPEG
                     FAYPKIGSNYSVKTVEKTWKALQDFKEGNALFTFPNTPVKCAGAPQKIMYLSEAYFRK
                     TGKRSKANIIFNTALGTIFGVKKYADALQEIIRERNVSVNYKHNLIEVRADKQEAVFE
                     NLDKPGETHVIHYEMLHVTPPMSSPDVLKRSPVADSAGWVDVDKETLQHKKYPNVFGI
                     GDCTNLPTSKTAAAVAAQSGILDRTISLIMKNQTPTKKYDGYTSCPLVTGYNRVILAE
                     FDYTAQPLETFPFDQSKERISMYLMKADMMPFLYWNMMLRFNA"
     misc_feature    279..1235
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     misc_feature    279..1235
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     exon            303..473
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            474..527
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            528..722
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            723..932
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1116
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1184
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1363
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1886
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtagttt ctgctgcgcc agcgctgggg cccacggtgt cgctcagccg gcctgatcta
       61 ccctggtgat ggccccactg gttgctgttg tatccagtcc acgtgcccgg ctctttgctt
      121 gtttccttag gctgggcact cagcaggctg gacccctcca attgcatacg ggagcctgct
      181 gcacagccaa gaaccactat gaggtgctgg tacttggtgg gggaagtggt gggatcacca
      241 tggccactcg catgaagagg agagttggag cggagaatgt ggccattgtt gaacccagtg
      301 agaggcattt ctaccagcca atctggacac tagtgggtgc tggtgccaaa gagctgtcct
      361 catcggaccg ttctacactg agtgtgattc catccggtgt gcagtggatt caagatagag
      421 tggcggaact gaacccagat cagaactgta tccgcacaga caatggcaag gagatctcct
      481 acagatatct tatcatcgct cttggaatcc agctggacta tgagaagatt aaaggactac
      541 ctgaaggctt tgcttatcca aaaatagggt ccaattactc agttaagaca gtggagaaga
      601 catggaaggc cctgcaggac ttcaaggaag gcaatgccct tttcaccttc ccaaacactc
      661 cagtgaagtg tgctggtgcc ccccagaaga tcatgtacct atcggaagcc tacttcagaa
      721 agactggaaa gcgatccaag gctaatatca tcttcaacac agcccttgga acaatttttg
      781 gagttaagaa gtacgcagat gctttgcagg agatcattcg ggagaggaac gtttctgtca
      841 actataagca caatcttatt gaggtccgag ctgacaaaca ggaggctgtt tttgagaacc
      901 tggacaagcc tggggagaca catgtgattc attatgaaat gcttcacgtc acgccaccca
      961 tgagctcgcc agatgtcctc aagaggagtc ctgtggccga ttctgctggc tgggtggacg
     1021 tggataagga gactctgcag cataagaaat acccgaatgt gtttggcatc ggggactgca
     1081 ccaacctccc aacttcaaag acggctgctg cagtagctgc ccaatctgga atccttgata
     1141 gaacaatttc tctgattatg aagaatcaaa cacccacaaa aaagtatgat ggctatacct
     1201 cgtgcccact ggtgactggt tacaaccgtg tgattcttgc tgagtttgac tacacagctc
     1261 agcctctgga aaccttcccc tttgatcaga gtaaagaacg aatttccatg tacctcatga
     1321 aggctgacat gatgccgttc ctgtattgga atatgatgct aagattcaat gcataagatg
     1381 ctggcttcat tgcagaagaa ggaatggaag gattgtaatg gatcaaggaa gagagagtta
     1441 gaaggaagag tagaagaaag aagccacagc caaaaataat actctgacaa aatatgagtt
     1501 caattgggag aactataaaa ctgataactt gtagattaga agaccatgaa gcaacaaatc
     1561 tatattaaga actacagtta atgaaggaag ttgagagtag gaagagggga acaaatggtt
     1621 attctacatc acatggtcag ccctgcaaac atatgtacaa gctaaactat ttattggagc
     1681 actacatact tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgattg
     1741 tatcaagaat atgtgaagaa agcagtcaca gaatttaact ggatcatgtg ggtacatatg
     1801 ggagcattat gagggaggaa agggatgttg aaaattatgt tatattaatt caagaacaaa
     1861 ataaatggag ataaaatgga atgtaa
//
LOCUS       NM_001437863            3570 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 14, mRNA.
ACCESSION   NM_001437863 XM_017599577
VERSION     NM_001437863.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3570)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3570)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3570)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3570)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3570)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3570)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3570)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3570)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3570)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3570)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_017599577.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1822499.1,
                                           SRR26643298.56240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1059           JAXUCZ010000015.1  3590901-3590944
            1060-1092           JAXUCZ010000015.1  3598315-3598347
            1093-1137           JAXUCZ010000015.1  3601575-3601619
            1138-1186           JAXUCZ010000015.1  3604223-3604271
            1187-1262           JAXUCZ010000015.1  3607566-3607641
            1263-1357           JAXUCZ010000015.1  3607997-3608091
            1358-1602           JAXUCZ010000015.1  3609598-3609842
            1603-3570           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3570
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1590
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 14 is encoded by transcript variant 14;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 14"
                     /protein_id="NP_001424792.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKS
                     SSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNG
                     DFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVI
                     GEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1189..1572
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1189..1572
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1092
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1137
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1186
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1262
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1357
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1602
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3570
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagctgcc
     1021 aagagcctat tgaacaagaa gtcagatggc ggcgtcaaga aaaggaagtc gagttccagc
     1081 gtgcacctaa tggagccaca aaccaccgtg gtacataatg ctacagatgg gatcaagggc
     1141 tccacagaga gctgcaacac caccacagaa gacgaagatc tcaaagtgcg aaaacaggag
     1201 atcattaaga tcacagaaca gctgatagaa gccatcaaca atggggactt tgaggcctac
     1261 acgaagattt gtgacccagg cctcacttcc tttgagccag aagcccttgg taacctcgtg
     1321 gaggggatgg atttccataa gttttacttt gagaatctcc tgtccaagaa cagcaagcct
     1381 atccacacca ccatcctaaa cccacatgtc catgtcatcg gcgaggacgc agcttgcatc
     1441 gcctacatcc ggctcaccca gtacatcgat gggcagggtc ggcctcgcac cagtcagtca
     1501 gaggagaccc gggtgtggca ccgccgggat ggcaagtggc tcaatgtcca ctatcactgc
     1561 tcaggagccc ctgctgcacc gctgcagtga gctcaggcac aggggcatta ggagattcca
     1621 gctggaggct gaaccttcga agtcagtgac tctggagggc ctgagtgaca gccgcggtcc
     1681 tgtccatttg aggtttaaaa caattacatt acaaagcggc agcagccaat gcacgcccct
     1741 gcatgcagcc ctcccgcccg cccttcgtgt ctgtctctgc tgtactgagg tgttttttac
     1801 atttaagaaa aaaaaaagaa aataagattg ttttaaaaaa aaatggaatt cataccatga
     1861 tgcgttttaa aacaactgat agcctttggg cttgaagaag gcaggagttt gtatgatgct
     1921 catccaggcg tgaacagagg gctcacccac tggctttgaa gaggtgagct tggcctcagg
     1981 cccccatgga ctcggggggg accaggcaag gactcttgac agagctttgg tcatggacag
     2041 agccatgctg tggttgcagc cccggtggtg acctgatcac tccaggtcta ggagtggact
     2101 tcttcagaat atacattgac acctagtatg agaaagaaga aaactccatg gctaacagac
     2161 ctacttggga gagaacgcag cgctcccagc ccgctgtgga ggcaactgtg aagcgtggcc
     2221 tcgggactga aggcctggac tttgccgtac cgttccagtt agtgtagaca ggaagagaat
     2281 tggtgctgca gaagtgtgtc cgacacagag ccggtgtgaa acctcgcgtt agtctgacac
     2341 gcacttactc atccatttct ataggatgca caatgcacgt gggcctgaga ctgaggcctg
     2401 atttctgcag gcgagaaggg ggtgggattg ctactttgtt tcctgttggt tttcctaatg
     2461 tatcaaggag agatccagac atcgttggcc agggctcctg ttgccacttt ctgcagttgt
     2521 gtttgtgtgc ggatctggac cactttgtct tatattttcg tggcggtggt ccccatgccg
     2581 accctctgcc aagtgcccct gcgggatggg aggagtgaga taagagttgg tggttgtttc
     2641 tatgcattct ggctgccctc tgggctgcct cccttcttcc cgtgctgcac gtccgtctct
     2701 ttccctgagt ttgagattga accgactgct tgggtgagaa gtgtcctctt taatgaggct
     2761 ctctaccgac caactgaagt atagactttt ctgctggaca atctgcatgg gcatcacccc
     2821 ctcacctgca tgtacccaaa aaggggtcca gagccaaggc tcctgtagtc attgtccctc
     2881 tctgtgctca aggagttcct ttccaggagg aaaagatctg taccttaggc agataacaga
     2941 gaagacaatg gaggagcaat tggtcatagt cttggttccc tcccacccaa cagctgcaca
     3001 ctatctgcat tttggggggg aaggtgggtt gacttcagct ctttggatga ccttcaggga
     3061 ggcacaggag ctgggaaaag atacagaact acagactttg gaaccagctg agaagagaac
     3121 aaactcatgg gtgctggtgc ttgaatttag ccaggctcct caagcacctt gtgcatgcct
     3181 cagaccctgg accctagccc cttcctgccc tgcagcctgc agtgccagcc aacagatccc
     3241 ttcaccacag ggtttggttt tgctggcttg aagacaacaa atggtcttag agctcattga
     3301 gacccatagc ttcatatggc tgctccagcc ccacttagcg ttcttactcc acttctgggg
     3361 ctaatgtcag catctataga caattaatag actatttaaa aaaaaaaacc accttttaaa
     3421 caggaaatga aaggcatttg atgcagaact tttgcatgac gacatagaaa taatttaaaa
     3481 atagtgtttg ttctgaatgt tggtagtccc ttcatagctt tgttacaatg aaaccttgaa
     3541 gatatttaat aaaataacct ttaaacagtc
//
LOCUS       NM_001437848            1647 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus prolactin receptor (Prlr), transcript variant 4,
            mRNA.
ACCESSION   NM_001437848 XM_039101752
VERSION     NM_001437848.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Vergara-Castaneda,E., Grattan,D.R., Pasantes-Morales,H.,
            Perez-Dominguez,M., Cabrera-Reyes,E.A., Morales,T. and Cerbon,M.
  TITLE     Prolactin mediates neuroprotection against excitotoxicity in
            primary cell cultures of hippocampal neurons via its receptor
  JOURNAL   Brain Res 1636, 193-199 (2016)
   PUBMED   26874070
  REMARK    GeneRIF: This study demonstrated that the Cultured neurons
            expressed mRNA for both PRL and its receptor (PRLR), and both PRL
            and PRLR expression levels changed after the excitotoxic insult.
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Rojas-Duran,F., Pascual-Mathey,L.I., Serrano,K., Aranda-Abreu,G.E.,
            Manzo,J., Soto-Cid,A.H. and Hernandez,M.E.
  TITLE     Correlation of prolactin levels and PRL-receptor expression with
            Stat and Mapk cell signaling in the prostate of long-term sexually
            active rats
  JOURNAL   Physiol Behav 138, 188-192 (2015)
   PUBMED   25446202
  REMARK    GeneRIF: Results showed that an active sexual life, with constant
            execution of sexual behavior, produces a sustained increase in
            serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
REFERENCE   4  (bases 1 to 1647)
  AUTHORS   Arumugam,R., Fleenor,D. and Freemark,M.
  TITLE     Knockdown of prolactin receptors in a pancreatic beta cell line:
            effects on DNA synthesis, apoptosis, and gene expression
  JOURNAL   Endocrine 46 (3), 568-576 (2014)
   PUBMED   24114406
  REMARK    GeneRIF: PRLR signaling is required for DNA synthesis and survival
            of rat insulinoma cells
REFERENCE   5  (bases 1 to 1647)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 1647)
  AUTHORS   Ali,S., Pellegrini,I. and Kelly,P.A.
  TITLE     A prolactin-dependent immune cell line (Nb2) expresses a mutant
            form of prolactin receptor
  JOURNAL   J Biol Chem 266 (30), 20110-20117 (1991)
   PUBMED   1718958
REFERENCE   7  (bases 1 to 1647)
  AUTHORS   Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.M.,
            Edery,M., Djiane,J. and Kelly,P.A.
  TITLE     Expression of two forms of prolactin receptor in rat ovary and
            liver
  JOURNAL   Mol Endocrinol 4 (8), 1136-1143 (1990)
   PUBMED   2293022
REFERENCE   8  (bases 1 to 1647)
  AUTHORS   Zhang,R., Buczko,E., Tsai-Morris,C.H., Hu,Z.Z. and Dufau,M.L.
  TITLE     Isolation and characterization of two novel rat ovarian lactogen
            receptor cDNA species
  JOURNAL   Biochem Biophys Res Commun 168 (2), 415-422 (1990)
   PUBMED   2159291
REFERENCE   9  (bases 1 to 1647)
  AUTHORS   Boutin,J.M., Jolicoeur,C., Okamura,H., Gagnon,J., Edery,M.,
            Shirota,M., Banville,D., Dusanter-Fourt,I., Djiane,J. and
            Kelly,P.A.
  TITLE     Cloning and expression of the rat prolactin receptor, a member of
            the growth hormone/prolactin receptor gene family
  JOURNAL   Cell 53 (1), 69-77 (1988)
   PUBMED   2832068
REFERENCE   10 (bases 1 to 1647)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_039101752.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092133.1, SRR26643429.7268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000002.1  60899219-60899316
            99-158              JAXUCZ010000002.1  60992578-60992637
            159-268             JAXUCZ010000002.1  61012956-61013065
            269-401             JAXUCZ010000002.1  61016362-61016494
            402-571             JAXUCZ010000002.1  61018046-61018215
            572-741             JAXUCZ010000002.1  61027952-61028121
            742-883             JAXUCZ010000002.1  61029594-61029735
            884-983             JAXUCZ010000002.1  61030181-61030280
            984-1053            JAXUCZ010000002.1  61030794-61030863
            1054-1647           JAXUCZ010000002.1  61051290-61051883
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1647
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
     exon            1..98
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            99..158
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            159..268
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    181..183
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="upstream in-frame stop codon"
     CDS             214..1146
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="isoform b precursor is encoded by transcript
                     variant 4; PRL-R; lactogen receptor"
                     /codon_start=1
                     /product="prolactin receptor isoform b precursor"
                     /protein_id="NP_001424777.1"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
                     /translation="MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     QMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFT
                     MEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESS
                     VEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLETGSPSKYKVDLYLALPGGFQKLDNAGELDY"
     sig_peptide     214..270
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    268..558
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    268..558
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    373..375
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    508..510
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    577..870
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    577..870
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(577..579,790..792,835..837)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(577..579,790..792,835..837)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    592..594
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    841..855
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: WSXWS motif"
     misc_feature    order(841..846,850..855)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(841..846,850..855)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    901..972
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     transmembrane region"
     misc_feature    997..1023
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Box 1 motif"
     exon            269..401
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            402..571
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            572..741
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            742..883
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            884..983
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1053
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1647
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttgaggg agactgttgt gatgttcggc cgtcccctct tgtgcgcatg cagctcctac
       61 cacagctaac ctttacacct ggtgctctag agacaaagct aaaggacact tctctgtgaa
      121 ggtgagcact gcagatgttt tgcacatgag ccctgaaggg agcctctgat acattgccta
      181 tagcaagaag aaggggccaa cctgaagaaa aacatgccat ctgcacttgc tttcgtccta
      241 cttgttctca acatcagcct cctgaaggga cagtcaccac cagggaaacc tgagatccac
      301 aaatgtcgct ctcctgacaa ggaaacattc acctgctggt ggaatcctgg gacagatgga
      361 ggacttccta ccaattattc actgacttac agcaaagaag gagagaaaac cacctacgaa
      421 tgtccagact acaaaaccag cggccccaac tcctgcttct ttagcaagca gtacacttcc
      481 atctggaaaa tatatatcat cacagtaaat gccacgaacc aaatgggaag cagttcctcg
      541 gatccacttt atgtggatgt gacttacatc gttgagccag agcctcctcg gaacctgaca
      601 ttagaagtaa aacagctaaa agacaaaaaa acatatctgt gggtaaaatg gtccccaccc
      661 accataactg atgtgaaaac tggttggttt acaatggaat atgaaattcg attaaagcct
      721 gaagaagcag aagagtggga gatccatttt acaggtcatc aaacacagtt taaagttttt
      781 gacctatatc cagggcaaaa gtatcttgtc cagactcgct gcaagccaga ccatggatac
      841 tggagtagat ggagccagga gagttccgtt gaaatgccaa atgacttcac cttgaaggac
      901 acaaccgtgt ggatcattgt ggccattctc tctgctgtca tctgtttgat tatggtctgg
      961 gcagtggctt tgaagggcta tagcatgatg acctgcatct ttccaccagt tcctgggcca
     1021 aaaataaaag gatttgatac ccatctgctg gagactggtt ctccaagcaa atacaaggtg
     1081 gatctgtacc tggcccttcc tggaggattc cagaaactgg acaatgcagg ggaacttgac
     1141 tactgaagct gcagactcaa ataggagcct ctcaaaatgg gttctaccac catcgcaaca
     1201 aatgctgaga acaagacaga aatttcccag tgccaataat ctagtatcca ggacgcctgc
     1261 ctggttagac tttaaatttg ctcaatgaca aacgagatca gtgttaattg tgtttcttga
     1321 gcagctctcg tttgtttttc tcttttgtca gcctcagcca tctgccatct tgatccctca
     1381 gtctcacgtg gtgatatcta tctttctgtg tgtgtgtgta tctctgtgtg tctctctgtg
     1441 tcatctctct gtctctatgt gtctctgttc ctctgtgtct tcctttgtcc tttgtgttct
     1501 ctctctctct ctctctctct ctctctctct ctctctctct ctctctccaa cttgcttcat
     1561 gcttttctgg gcttgagtgt gcttaagaaa acacatttta cgatcatcag aataaccccc
     1621 cctttaaata aaaaactgtc ataatca
//
LOCUS       NR_199368               7045 bp    RNA     linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus SNF2 histone linker PHD RING helicase (Shprh),
            transcript variant 2, non-coding RNA.
ACCESSION   NR_199368
VERSION     NR_199368.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7045)
  AUTHORS   Zeman,M.K., Lin,J.R., Freire,R. and Cimprich,K.A.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   2  (bases 1 to 7045)
  AUTHORS   Motegi,A., Liaw,H.J., Lee,K.Y., Roest,H.P., Maas,A., Wu,X.,
            Moinova,H., Markowitz,S.D., Ding,H., Hoeijmakers,J.H. and Myung,K.
  TITLE     Polyubiquitination of proliferating cell nuclear antigen by HLTF
            and SHPRH prevents genomic instability from stalled replication
            forks
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12411-12416 (2008)
   PUBMED   18719106
REFERENCE   3  (bases 1 to 7045)
  AUTHORS   Motegi,A., Sood,R., Moinova,H., Markowitz,S.D., Liu,P.P. and
            Myung,K.
  TITLE     Human SHPRH suppresses genomic instability through proliferating
            cell nuclear antigen polyubiquitination
  JOURNAL   J Cell Biol 175 (5), 703-708 (2006)
   PUBMED   17130289
REFERENCE   4  (bases 1 to 7045)
  AUTHORS   Unk,I., Hajdu,I., Fatyol,K., Szakal,B., Blastyak,A., Bermudez,V.,
            Hurwitz,J., Prakash,L., Prakash,S. and Haracska,L.
  TITLE     Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent
            polyubiquitylation of proliferating cell nuclear antigen
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18107-18112 (2006)
   PUBMED   17108083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1504527.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000001.1  7349255-7349314
            61-713              JAXUCZ010000001.1  7351308-7351960
            714-843             JAXUCZ010000001.1  7355004-7355133
            844-1062            JAXUCZ010000001.1  7357118-7357336
            1063-1141           JAXUCZ010000001.1  7359535-7359613
            1142-1292           JAXUCZ010000001.1  7360560-7360710
            1293-1401           JAXUCZ010000001.1  7362013-7362121
            1402-1655           JAXUCZ010000001.1  7363203-7363456
            1656-2333           JAXUCZ010000001.1  7364754-7365431
            2334-2585           JAXUCZ010000001.1  7366890-7367141
            2586-2664           JAXUCZ010000001.1  7368083-7368161
            2665-2828           JAXUCZ010000001.1  7370243-7370406
            2829-3085           JAXUCZ010000001.1  7370509-7370765
            3086-3207           JAXUCZ010000001.1  7372111-7372232
            3208-3296           JAXUCZ010000001.1  7379066-7379154
            3297-3389           JAXUCZ010000001.1  7381878-7381970
            3390-3497           JAXUCZ010000001.1  7384115-7384222
            3498-3640           JAXUCZ010000001.1  7385336-7385478
            3641-3814           JAXUCZ010000001.1  7386175-7386348
            3815-3877           JAXUCZ010000001.1  7386633-7386695
            3878-4103           JAXUCZ010000001.1  7387666-7387891
            4104-4247           JAXUCZ010000001.1  7388633-7388776
            4248-4349           JAXUCZ010000001.1  7389892-7389993
            4350-4421           JAXUCZ010000001.1  7391376-7391447
            4422-4610           JAXUCZ010000001.1  7399780-7399968
            4611-4806           JAXUCZ010000001.1  7413389-7413584
            4807-4899           JAXUCZ010000001.1  7414199-7414291
            4900-4986           JAXUCZ010000001.1  7414926-7415012
            4987-5165           JAXUCZ010000001.1  7415632-7415810
            5166-5246           JAXUCZ010000001.1  7419874-7419954
            5247-7045           JAXUCZ010000001.1  7421003-7422801
FEATURES             Location/Qualifiers
     source          1..7045
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..7045
                     /gene="Shprh"
                     /note="SNF2 histone linker PHD RING helicase"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
     misc_RNA        1..7045
                     /gene="Shprh"
                     /product="SNF2 histone linker PHD RING helicase,
                     transcript variant 2"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
     exon            1..60
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            61..713
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            714..843
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1062
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1141
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1292
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1401
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1655
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2333
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2585
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2664
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2828
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3085
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3207
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3296
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3389
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3497
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..3640
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3814
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3877
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..4103
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4247
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4349
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4421
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4610
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4611..4806
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4899
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4900..4986
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5165
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5246
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..7045
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatctgca ggctccgagg agggccggtc ctcgcgactg gtgctcgtat agcggttgag
       61 aattcacgtt taccaaccaa gaaagggaaa gctcgaggat gagtagccga aggaaacgtg
      121 ctcccccgat gaaggtggat gaagaaaggc agcagcagct tcgctggaac atgcacgagg
      181 acctgaggaa tgagccgctc agcttgactg aggaagagcg ggcctgctgg gatgcagact
      241 cctccgattg catcatcata gatgatgacc ctcccgaagg tgcagctcac agagataaga
      301 agaggtgtac agagtctgtg agcatcttaa actccactga aaaagagacc cctctgtccg
      361 tggccttgaa tgttaccatt tctccccatc cttccgatga ttcttggaaa gcgtttctgg
      421 gagattttgt gcttcagctt ctccctgaag agagtttagt tgaacatttt tctgaaagga
      481 cttttacgtt gatgagttca gagtcaagca gtcagctcct gatctatgtt cattcagaat
      541 gtaacaatgt ggagaaagaa gaaaacgtac ttaaaggacc agcaagtatc tatggcaagg
      601 gtattcgagt ggaatcctcc ttcagtagtg acatgttaca ggatttggcc tggctacaga
      661 agagaagagg aataaaactc taccagcgac cagaaggaac tcatacgatc aaggttagaa
      721 tttacctctt ggaagctggc ctgacaagac tagacttcat gagtgatgca ggctccagaa
      781 tgaaaaagtt caatcagctc ctgaagagag tgatgggaaa gttatacagt ctcagtattc
      841 cagatgtgtt ggaagaagat gaggaggaat cagagagtga gccagagggc caggacattg
      901 atgagctcta tcagtttgtg aagcgaacac accagcaaga ggcaaagtca gtccaagtgg
      961 atgtccagca ccctgcactg attccggtgc tgaggccgta ccagagagag gcagtcaact
     1021 ggatgctaca gcaggagcag ttcaggagca ctcctgctgg tgataactcc ctgcacttct
     1081 tgtggcgaga aattgttaca cctgatggct tgaacctcta ctataatccg tacacaggct
     1141 gcatcattcg ggacttccca catgctgggc cacagttgct cggtggaatc ttagcagatg
     1201 agatgggcct cgggaagaca gtggaggttc tggctctgat tctgactcat acccgacaag
     1261 atgtcagaca ggatgccctc accctgcctg agggaaaagt ggtaaattat ttcatcccaa
     1321 ctcattgtcc tagaggaaaa gtgaaaagta gagaaatcca gaatacagag tgtgaaccaa
     1381 aagagaaagt tcactgccct cccacacgtg tgatgattct gacagctgtg aaagaaatga
     1441 atgggaaaaa aggcgtttct attctttcta tctataagta tgtcagctcc acattcagat
     1501 acgacgttca gcggaaccgg agtcttctga agcggatgtt gaaatgttta atctttgaag
     1561 gtcttgtgaa acagattaaa ggccgtggtt tctctgggac ttttacactg ggaaagaatt
     1621 acaaagaaga tgtatttgat aaaacgaaaa agcaggcagt agggagtcca caaaaaattg
     1681 agaaagagtt aaggaaatca gtgaacaagg atacagattc tgaatacatg ccatcagaca
     1741 tttatgatga cgataatgac aacgacgatg acgacgacga tgatccttat tattattact
     1801 gcaaggcaag aaaaagccgt aagttgaaga agaagcctgt gttactcact aaaaaggaaa
     1861 agggtcagcc tgtcaatctg gattcccaag ttgaggctcc agctgctggt gactgtgcaa
     1921 gcgccgatgc tcatgtgtca gaaagtacat gtgtctctga aaacaggcag atccaagacg
     1981 cagaggactg tgttgagtct ccaagcccgg ccgccatgga gctggcacag tctaacactg
     2041 caagtttctg tgagacccct gactaccgct ttgagtgtat atgtggtgaa tttgaccaga
     2101 tcggccgcaa gccaagagtt cagtgtctga agtgtcacct gtggcagcat gcaaagtgtg
     2161 tgaattacga ggagaagaat ctgaaggtta agccttttta ctgccctcat tgcctggttg
     2221 caatggagcc agtgtcaacc agagcgactc tcatcatctc cccaagctcc atttgccacc
     2281 agtgggtaga tgaaatcaac cggcacgtga gatcgtcatc ccttcgagtt ttggtatatc
     2341 aaggagtgaa gaaagatggg ttcttacagc ctcatttttt ggcagaacaa gatatagtta
     2401 tcattaccta tgatgttctc cgttcagaat taaactatgt cgatatccca catagcaata
     2461 gtgaagatgg gcgtcgcctg aggaaccaga agcgctacat ggccattccc agccccctgg
     2521 tagcggtgga gtggtggcgg atctgtctgg atgaagcgca gatggtcgag tgtcctacag
     2581 taaaagctgc agaaatggcc cagcgtttga gtggcattaa tcggtggtgt gtcagtggca
     2641 ctccagtgca gagaggattg gaagatcttt ttgggctggt ggtctttctt gggattgaac
     2701 cttattgtgt caaacactgg tggattcgac ttctctatca tccatactgc aagaaaaatc
     2761 ctcaacacct gtacagtttt attgctaaga taatgtggag gtccgcaaag aaagatgtca
     2821 ttgaccaaat ccagatccca cctcagactg aagaaatgca ctggctccat ttttcccctg
     2881 tggagaggca tttctaccac cgccagcatg aggtgtgctg ccaggatgct gtggtaaagc
     2941 tcaggaagat ctcggactgg gccctgaagc tgagcagctt ggacagaagg acggtctcct
     3001 ccatcctgta ccccctgctg agactcaggc aggcctgctg ccacccacag gctgtgcgtg
     3061 gggagttcct gccactccag aagagcacca tgacgatgga ggagttgctg acatctttgc
     3121 agaagaagtg tggaacagag tgtgaagagg cccaccggca gctagtttgt gcccttaacg
     3181 gcttagcagg catccacatc attaaaggtg aatacgcctt ggcagcggaa ctctacagag
     3241 aagttttaag gtcgtctgag gagcacaaag gaaaactcaa aactgattca cttcaaagac
     3301 ttcacgccac acataacctg atggagctcc tggtagccaa acacccaggg ataccgccca
     3361 ccctgagaga tggcagactt gaagaagagg ccaagcagct ccgagagcac tacatgagca
     3421 agtgtaacac agaggtggcc gaagcccagc aagctttgca gcctgtgcag cagtccattc
     3481 gggagctcca aaggaaggtt cattctggtt ctccttggtg gctgaatgta gttcacagag
     3541 caatggagta tgctgttgac gaggagcttg ttcagcgcgt gcgaaatgag ataagcagta
     3601 actacaagca ccaaacggac aaactctcca tgtcagagaa gttccgtgac tgtagaggtc
     3661 ttcagttctt acttacaaca caaatggaag agctgcacaa gttccagaag ctagtgaggg
     3721 aggctgtgaa gaagctggag aaacctccgt cccgggatgt gattgagtct gcaacagttt
     3781 gccacctgcg gccagctaga ctccctctca actgctgtgt cttttgtaaa gctgatgaat
     3841 tgttcacaga gtatgagtca aagctatttt ctaacactgt caaaggccag accgccatct
     3901 ttgaagaaat gatagaagat gaagaaggac tcgtggatga tagagtccct accactacca
     3961 gaggcctgtg ggccgtgagc gagacggagc gatctatgaa agcaatacta tcatttgcaa
     4021 gatcacatag gtttgacgtt gaatatatag atgaaggaag tgtttcaatg gatctcttcg
     4081 aggcatggaa gaaggagtat aagttacttc atgaatactg gatgactctg agaaaccgcg
     4141 tatccgctgt tgatgaactt gcaatggcta cagagcgact aagagtgcgc catcccaagg
     4201 agccaaagcc aaacccaccc gtccaccaca tcattgaacc acacgaggtt gaacagaatc
     4261 gtataaaact agtaaatgat aaagctgttg ctacttccca gcttcagaag aaacttggac
     4321 agcttcttta cctgacaaat ttggagaagt ctcaggacaa aacatcagga ggtattaatc
     4381 cagagccttg tccgatctgt gctcggcagt tgggaaaaca gtgggcagtg ctgacctgcg
     4441 gacactgctt ctgtaatgaa tgcacttcaa ttataattga acaatacagt gtgggatccc
     4501 atcgaagctc cattaagtgt gctatctgcc gccagaccac atcacacaaa gaagtctcct
     4561 atgtcttcac ttcagagaag gcaaaccaag aggatgatat ccctgtgaag gttttaaacc
     4621 acttttctat ttccatattc ctgtgatgca acagttttga aagatgaaaa ataaaacaga
     4681 aaaaatatct tgtaaagtga ctttatctgc ctgtgtgtta gtggacatct tgtgtctctg
     4741 tcattgtcca tggtcatgcc attgcaaaga aattgtattc attggttgaa tccttcagtt
     4801 ttcaagggta gccattctac aaaagtggaa gctgtggtca gaactctgat gaaaatacaa
     4861 cttaaagatc cgggggccaa agcgctcgtt ttctcaacgt ggcaagatgt gttagatatt
     4921 atttcaaaag ctctcacgga caacaacatg ggattcacac aaatcagtcg cattaagaca
     4981 ttccaggaga acctttcagc atttaaatat gatccccaga tcaatatttt gctgctgccc
     5041 ctgcatacag gctctaatgg attaactatc attgaagcca ctcatgtcct cctggtggaa
     5101 ccgatactga atcctgccca tgagcttcag gccattggga gagtgcaccg aattggacag
     5161 acaaaaccta ctattgtaca tagattctta attaaagcaa caatagaaga gcggatgcag
     5221 gcaatgctaa agactgctga gaggagccac accagctcgt ctgggaagca ttctgaagcc
     5281 tctgcactga ccgtggctga cctggcagac ctgttcacca aagagagtga ggagcttgaa
     5341 tgaagcgcca tcgcgtcatt gcacggatgt tcagacttag ctctcacaga tgtaaagcaa
     5401 gcttacaaag ttaagatcag taaccattag tagatactat tttaatgaat tgattttgtt
     5461 atacaccagc ctagtaataa ttggcaattg gttccttttc agtaaaccta tttcacacca
     5521 tttacaatga attttaattt tacattccta ctgaaacatt tactttttgt tctacatgta
     5581 tatctataac tgataaggca ggagaattta aaaaagaagg tattaaataa tttttcatta
     5641 gtagatagat gtttgttata acaagacaga atacataaga aagaaggtaa attagtctag
     5701 ttttgtatga cctgacctac acagccagtg taaatgacat ttttgaaagg gcctttggca
     5761 tctttagctt atgattcatc attctcttct cggtagtgtt ttaagaagac gctaaactat
     5821 gatacctagt tgtttgcatg agtttaaact gtaacactct ctttggaact ttaagtagta
     5881 cagctcctga tcataaattc ttaggtggtt attttgtgtc ttgttactag ccgtcaaaat
     5941 actgaaaagc tcatttttct attatgttta agccgtgtca ttgttagtgt ttttaagtgt
     6001 attaacattt acctacaatg atctctttaa tctttgtagt gagttctttt tgtgttttaa
     6061 gatgatgtat ctgtaaatag ggctttttta aaatcatcat tgtactgaat tctttccctg
     6121 tgttcctgta actaatcatt ttagccggta attatctaag tttacagtag agtttattca
     6181 tttcagttac tctgtcatta agtattttat cttactgcaa gagaatgctg tgttcacaca
     6241 tgcatagaac tataagtggt taaactgtct cttctgtgaa gacttcatag atgactttga
     6301 aatcacaaaa taagaagtag cttgtatcct aaccctgtgt tgaaatataa atgttcttgt
     6361 tttccttcct ttagctgttg aagttttaag tgactctcga gattcattag ctcctaccta
     6421 actgcccagg aagctgtact agaaatagtc cctggagctc cttcatccat tgagcttggt
     6481 gcttaagcta aggtgcattt tcctatccgg gtttataggt gacagctcag ctgaggaaga
     6541 cacattctgg gtgcttattc cttagtgaag ggagatatgc attggttctt ttatatgaga
     6601 ttaaacataa tatttttaca gctctttgac atccatgaag agcttttctg tgtattaatg
     6661 tagttaattt tcccaaccgt cctgtgaagt ggacataatt aaagtcattc ctgttgtgaa
     6721 ggtaaggagc gaatgctcag gaggaatctt ggctatgata tgtagcaaat agacagagga
     6781 gtccaggccc tggcttcatg tctgcttttc ttccaccaaa tcgtgtcatg ctgaggtcca
     6841 gaagcctcag aggtgtaatt taggggtgcg attgttgagg tttttctttt tcctaatatt
     6901 tcatgtgcta tgttctagga aaagcaatct gatatgcttc aattaaaaaa ataacataaa
     6961 tagatatctg tacttattag tattagaaaa actactctta tttatttcag taagatacct
     7021 caaataaata ttttagtgaa aaatg
//
LOCUS       NR_199369               4090 bp    RNA     linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus PNMA family member 8B (Pnma8b), transcript
            variant 2, non-coding RNA.
ACCESSION   NR_199369
VERSION     NR_199369.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.1639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2666              JAXUCZ010000001.1  86750391-86753056
            2667-4090           JAXUCZ010000001.1  86753182-86754605
FEATURES             Location/Qualifiers
     source          1..4090
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4090
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="PNMA family member 8B"
                     /db_xref="GeneID:308393"
                     /db_xref="RGD:1560435"
     misc_RNA        1..4090
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /product="PNMA family member 8B, transcript variant 2"
                     /db_xref="GeneID:308393"
                     /db_xref="RGD:1560435"
     exon            1..2666
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    407..2410
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001107481.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            2667..4090
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccgcagc ggccccgctg agcgtctaga cctggctacg cgcttcgctc cagactccgc
       61 gggagcacag gcgagccgct gctcccaccc accccacgcc caccaggtgc attgattgcc
      121 gtcctcctgt accccaccag ccgcgtccag tcgtctgggt tgtcagggac aaagggagga
      181 acaacccggg ccagcccgga gaacgtacac gtaagccccc tgcagaccct cggattgccc
      241 caggggaaga tcgttgcgtc gtcccgctag atagcaggta gctaaaaccc agagccccaa
      301 acccgagtct ggactctcac cctgcgggtg gcctttccag agtgggtttg acctagcctt
      361 tctcgggctc cctcccgccc aagattagcc tctgccaggc agcgccatga ctatgaacct
      421 tctgcaagat tggtgtaagg agctggaagt ggaggtgcac agggccctcc tgatcacggg
      481 catccccgag cgcctgcagc aggcggacat cgaagctacc ctgaggccga acttgcagcc
      541 cctgggcaac tacaggcttc gaactgtgag agccgtgacc aaggagaagg ctcaggccgc
      601 ccttgttgaa tttggggccg acttcgatca ctctgccata cctatccaca ttaggggaga
      661 gaatgggatc tggaaaatcc tgagtaagga ccgcgggcaa gatgcgcggg tccttaggca
      721 gatgaggcgc ctgttgctgg atgaaaggcc catggatgac ttcagagaaa ttgccatccc
      781 tctggtattg gaggcccagg cccaggccaa gggattaggg aaggaggcca agaaagctgg
      841 ctcctctgaa ggggcagcta ggagcggccg tcggggccgt cggggaggta agcggcgatc
      901 cagaagccac aagttgacgg ctcagaaggg ccagaagagg agccggggag gacgccgagc
      961 caggagtgag tcggaagact cttctgatga cagcctgggt atcgtcatag aggagatcta
     1021 cgcagaggac ctgagcgtag atgaagacca gagagccctg tatgccacac tccaagcagc
     1081 cgccaaagag ctcaccaaga agtgggcctt tcggggtgac caggacgaag gagatggccc
     1141 ccgagagttt ttggcacttg tcacggtcac cgacaaagct aaaaaggaag agatagagaa
     1201 agaccttcct gggacagaat ctatttgctt aaacatcaaa gacgaaaaga gcggggtccc
     1261 tgatttagtc gcgctactgg ctgtgagaga tacccccgca gtggaggtag aaacagaagt
     1321 ggaggatgat gatgaagaag atgacgatga tgacgatgat gaagacgaag atgaagacga
     1381 agatgatgac gaagatgacg atgacgatgg ttccgacagc gagtctctgg aaaatggaga
     1441 gcaagggaag gaagtaatgg acagccccga gtttgtggct atcgtggctt atacagaccc
     1501 cgccgacccg tctgccagag aagaaatgct gaaaatcgct tctgtgattg agaccctcgg
     1561 ttggggcgat aaaaaagaca aaaaagatgt ccttcctcaa gtcctgtccg tcatggccaa
     1621 ggacacctct gggcccaggg tgaaggtaga agaggcaggt cgccaggtgg acgccatggt
     1681 tctgaggaag gcagaggaag atgggaatct tctggaatgt atttccacct tggctgaagc
     1741 agagaactgc cctaaaggaa agaaatctgg gctaggtctc ctcagaggct ggaccgctga
     1801 gggccaccag ggtggcctct tggagctggt ggcactcctg gctgctcaag atatggtgga
     1861 agctgtgaga gaggaagaag ccagcaggtg gggcggtggt ggaagtggtg gccggaagtg
     1921 tgatcacagc caaggtggtt tatccgaggt cctggctttc ctggcctccc aggagaatct
     1981 cgaatccaac gaggaatcgg aggaagattc agacacagag tcagagggag attccgagga
     2041 cactgacagc gaagagtcag aacctggtga cagcgtgtcc aagaagccgc gcgccaagag
     2101 agcgcgcacc ggctccaaag gcttggcacc ggccggcgcc accgcggtct ccaccgggtc
     2161 ccgggcacgc aaaacccgca ggggtggccg cggtcgtggc cgcggtgtca ccccagagaa
     2221 gaaagcgggg agcggggctt caaccgagga ccatgcgggg aacaacaaaa agaagaagaa
     2281 gaagggatcc gcaggcgccg gggcccgtgt cagggctggt gaggccaagg gacagccagc
     2341 tgctgttccc aagtctaccc gcggaaagaa agcacgcagg ggcccaaggc gggcgcccaa
     2401 atgccgttag tgccgcagat gtcactacga gccccgtctc ttgtgtgtgg acttccccct
     2461 tcccgtttcc tcctattctc tcttctccct gcagcttccc tctcgcttaa ccgcgtgcat
     2521 ttgctttgtg ctccgctgtg tccctggctg gctatggccg gtgcccagct ttccctctca
     2581 gttccatgaa cagatggcat gagcgatcat tatggctgca gcctagatac aaggaaaaga
     2641 gacaaggcac tcggatgcag tggccggcac ctgtttctgg cggagccgtt gggatctact
     2701 gggagccacc tctggccctg acggggcatt agggagaagc aagagtgatg ggcacaatgc
     2761 gtattagggg attttggaag ggttaagggc cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2821 tgtgcgtgct tgcgcaagcg cgtgtgtgcg catgtgtgtc tgcgctcgcg cgcccgtgtg
     2881 tacatgcgtg tgtgtgtgtg tgcgcgtgcg cgcgcgtgcg ctcctgcgcg tgtgcgcgcg
     2941 tttatgtgtg tgtattttga gggaaaggta ttccataaat gcaagtctga gggggctggg
     3001 agctggagga ggaataaaaa tggaaggaga ggaggggaat gttggggggg gactggggag
     3061 gagggagaat aggggaacca ggaggaggaa ggaaggaagg cgtttgcatt agcccatcct
     3121 cctgaggctt tgcagttggg aacgaggggg aagctaagcc tccccccacc agcccgtgtc
     3181 cacaggttga actggtaata tactgccaat atgttctgat ttggaaaact tacatgaaat
     3241 ccagatttcc agctttctgg gcaagccttg cccctccgac tgtggtgccc cagctgtcag
     3301 tggccacccc tcagctgttt gcccttgtaa ctcttgactt aatgtaacaa tggagtccct
     3361 tgttcacccc cccccactcc aactgtgtgc agtaaagacc ccagatcccc ttaaagggtc
     3421 aagtgtccct attgtaggaa gcagttgctg tgccccaccc tggcatcatt agtcccccag
     3481 taaagcctgt ctgatgctgg ccactctcca gccctcagct gtccctgaaa acagccgctt
     3541 tagctgtgtg ttttcctgta gtgctacgcg ccagaagccc tggccgccta gttctgtgtt
     3601 tcgatgtgta gataatgctt tgccctgcac agcactttgc accctcttgt tcgtgtgtgt
     3661 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt tcaactttct atccccagga
     3721 agtgaccagt tcgtggtacc tggacctttt aggatgtaac agaagttctg accagcctca
     3781 cacccagacc gaactgtcca gctcctcagt ggggacatac agaaactgca gggggcatgg
     3841 gtacctcttt gtactcagag gcagccccac tccttgcttc ccaggaccag ggatgatgac
     3901 gggacagatg gagaagcagg ccaggggagc cttcggctgg agaggaaacc ccacttcatg
     3961 gtggctgatg gacttggggt gtggtggctg gggagggccc cacatgtcac ttccccttgc
     4021 atagttacag gtacctgtcc tcgtgtgctg tgtgatccgg gatcctcaaa tgaagcaatg
     4081 aagcatctta
//
LOCUS       NM_001191548            3911 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus DEAD-box helicase 54 (Ddx54), mRNA.
ACCESSION   NM_001191548 XM_002727973 XM_006249397
VERSION     NM_001191548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3911)
  AUTHORS   Liu,P., Zhang,Y., Li,X. and Ma,M.
  TITLE     DEAD-box helicase 54 regulates microglial inflammatory response in
            rats with chronic constriction injuries through NF-kappaB/NLRP3
            signaling axis
  JOURNAL   J Neurophysiol 130 (2), 392-400 (2023)
   PUBMED   37377223
  REMARK    GeneRIF: DEAD-box helicase 54 regulates microglial inflammatory
            response in rats with chronic constriction injuries through
            NF-kappaB/NLRP3 signaling axis.
REFERENCE   2  (bases 1 to 3911)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3911)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3911)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3911)
  AUTHORS   Rajendran,R.R., Nye,A.C., Frasor,J., Balsara,R.D., Martini,P.G. and
            Katzenellenbogen,B.S.
  TITLE     Regulation of nuclear receptor transcriptional activity by a novel
            DEAD box RNA helicase (DP97)
  JOURNAL   J Biol Chem 278 (7), 4628-4638 (2003)
   PUBMED   12466272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_006249397.4, NM_001191548.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1539782.1,
                                           SRR26360186.1252917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000012.1  41610324-41610522   c
            200-329             JAXUCZ010000012.1  41606909-41607038   c
            330-400             JAXUCZ010000012.1  41605793-41605863   c
            401-589             JAXUCZ010000012.1  41605236-41605424   c
            590-639             JAXUCZ010000012.1  41605089-41605138   c
            640-681             JAXUCZ010000012.1  41604373-41604414   c
            682-777             JAXUCZ010000012.1  41604183-41604278   c
            778-899             JAXUCZ010000012.1  41603682-41603803   c
            900-961             JAXUCZ010000012.1  41603531-41603592   c
            962-1093            JAXUCZ010000012.1  41603295-41603426   c
            1094-1304           JAXUCZ010000012.1  41602171-41602381   c
            1305-1442           JAXUCZ010000012.1  41600575-41600712   c
            1443-1676           JAXUCZ010000012.1  41600048-41600281   c
            1677-1750           JAXUCZ010000012.1  41599890-41599963   c
            1751-1942           JAXUCZ010000012.1  41599101-41599292   c
            1943-2085           JAXUCZ010000012.1  41597995-41598137   c
            2086-2199           JAXUCZ010000012.1  41597800-41597913   c
            2200-2304           JAXUCZ010000012.1  41597289-41597393   c
            2305-2420           JAXUCZ010000012.1  41596899-41597014   c
            2421-3911           JAXUCZ010000012.1  41595298-41596788   c
FEATURES             Location/Qualifiers
     source          1..3911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3911
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DEAD-box helicase 54"
                     /db_xref="GeneID:360815"
                     /db_xref="RGD:1562539"
     exon            1..199
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2653
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 54"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX54"
                     /protein_id="NP_001178477.2"
                     /db_xref="GeneID:360815"
                     /db_xref="RGD:1562539"
                     /translation="MAAGRRVGLGPRSHPAMAPWKKKRLRKRRTGASQARDSDSEDGE
                     FEIQAEDDARARKLGPGRALPSFPTSECVSDVEPDTREMVRAQNKKKKKSGGFQSMGL
                     SYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKAR
                     SAQTGARALILSPTRELALQTMKFTKELGKFTGLKTALILGGDKMEDQFAALHENPDI
                     IIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIGRLPGGHQTVLF
                     SATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFFLVREDTKTAVLLYLLQNVV
                     RPQDQNVVFVATKHHAEYLTELLTGQGVSCAHIYSALDQTARKINLAKFTHNKCSTLI
                     VTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLL
                     DLHLFLGRSVTLARPHEEPSSAGAVGRDGVLGRVPQSVVDDEDSSLQTALQASLELQG
                     LQRVANNAQQQYLRSRPAPSPESIKRAKELDLAELGLHPLFSSCFEEGELQRLRLVDS
                     IKNYRTRTTIFEINASSKDPSSQMMRAKRQRDRKAITSFHQGRQERQDGPADPVPQRE
                     LPQKEEEDMVETVEGVFTEVVGQKQPRPGPNQGAKRRRKEASQRDQEFYVPYRPKDFD
                     SERGLSVSGAGGAFEQQVAGAVLDLMGDEAQNMSRGRQQLKWDRKKKRFVGQSGQEDK
                     KKIKTESGRFISSSYKRDLYQKWKQKQKIDDRDSEEEGPSNRRGPGPHRGGKRGRSQG
                     ASQSRASSVPTGHMRSELKTKEQILKQRRQAQKQRFLQRGGLKQLSARNRRRAQELRQ
                     SAFGRGAPTRKGKMRKRM"
     misc_feature    311..925
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DEAD-box helicase domain of DEAD box protein 54;
                     Region: DEADc_DDX54; cd17959"
                     /db_xref="CDD:350717"
     misc_feature    311..925
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DEAD-box helicase domain of DEAD box protein 54;
                     Region: DEADc_DDX54; cd17959"
                     /db_xref="CDD:350717"
     misc_feature    order(368..373,377..385,392..394,446..469)
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350717"
     misc_feature    order(368..373,377..385,392..394,446..469)
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350717"
     misc_feature    956..1351
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; Region: SF2_C_DEAD; cd18787"
                     /db_xref="CDD:350174"
     misc_feature    956..1351
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; Region: SF2_C_DEAD; cd18787"
                     /db_xref="CDD:350174"
     misc_feature    order(1226..1228,1232..1234,1307..1309,1316..1321)
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350174"
     misc_feature    order(1226..1228,1232..1234,1307..1309,1316..1321)
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350174"
     misc_feature    2144..2326
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DBP10CT (NUC160) domain; Region: DBP10CT;
                     pfam08147"
                     /db_xref="CDD:462373"
     misc_feature    2144..2326
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /note="DBP10CT (NUC160) domain; Region: DBP10CT;
                     pfam08147"
                     /db_xref="CDD:462373"
     exon            200..329
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            330..400
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            401..589
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            590..639
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            640..681
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            682..777
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            778..899
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            900..961
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1093
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1304
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1442
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1676
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1750
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1942
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2085
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2199
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2304
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2420
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..3911
                     /gene="Ddx54"
                     /gene_synonym="RGD1562539"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttccggg tccgagtgcc cggcccgcat ggctgccggc agacgtgtgg ggcttggccc
       61 gcggtcgcat cccgccatgg ctccgtggaa gaagaagagg ctgcggaaac gccgaactgg
      121 ggcttcccag gcccgcgaca gcgattcgga ggacggcgag ttcgagatcc aagcagagga
      181 tgacgcccgg gcgcggaagc tgggccctgg cagagccttg ccctcatttc ccacctcaga
      241 gtgcgtatca gatgtggagc ctgacacccg agagatggta cgagcccaga acaagaaaaa
      301 gaagaagtct ggaggcttcc agtccatggg cttgagctac ccagtgttca aggggatcat
      361 gaagaagggc tacaaggtgc caacacccat ccagaggaag accatccccg tgatcttgga
      421 tggcaaggat gtggtggcta tggcccggac aggcagtggc aagacagcct gtttcctcct
      481 cccgatgttt gagcggctga aggcacgcag tgcacagacg ggggctcggg ccctcatcct
      541 ctcacccacc cgggagctgg ccctgcagac catgaagttc actaaagagc taggcaagtt
      601 cactggcctc aagactgcct tgatcctggg tggagacaaa atggaagacc agtttgcagc
      661 cctgcacgag aaccctgaca taatcattgc cacccctggg cggctggtgc atgtcgctgt
      721 ggagatgaac ttaaagctgc agagtgtgga gtatgtggtt tttgatgaag cagacaggct
      781 ctttgaaatg ggctttgctg agcagctaca ggagatcata ggccgccttc ctgggggcca
      841 ccagacagtg ctgttctcag ccacactgcc caaactgctg gtggaatttg cacgagcagg
      901 cctcacagag cccgtgctca tccgcctgga tgtagactcc aaactcaatg aacagctcaa
      961 gacttccttc ttccttgtgc gtgaggacac caagactgct gtgctcctct acctgctaca
     1021 gaatgtcgtt cggccccagg accagaacgt ggtgtttgta gccacgaagc accacgcaga
     1081 gtacctcaca gagttgctga cgggccaggg tgtgagctgc gcccacatct acagtgcctt
     1141 ggaccagacg gcccgcaaga tcaacttggc caagttcaca cacaacaaat gttccaccct
     1201 tatcgtgact gacctggctg cccggggcct ggacatccca ctgctggaca acgtcatcaa
     1261 ctacagcttc cctgccaagg gcaagctttt tctacaccga gtgggccgag tggccagagc
     1321 aggccgaagt ggcacagcct attccctggt ggccccagac gaagttccct acctgctcga
     1381 ccttcacctg ttcctgggcc gctctgtcac cctagcccgg cctcatgagg aaccttcttc
     1441 agcaggtgca gttggcaggg atggtgtgct gggtcgggtg ccacagagtg tagtggatga
     1501 cgaggacagc agcctgcaga ccgccctgca ggcgtcactg gaacttcagg gtctgcagcg
     1561 tgtggccaac aatgctcagc agcagtacct gcgctcgcgt ccggcaccct caccggagtc
     1621 catcaagaga gccaaggaac tggacctggc agagctgggc ctgcacccac tcttcagctc
     1681 gtgctttgag gagggagagc tccagcgcct gaggctggta gacagcatca agaactatcg
     1741 cacacgcaca accatcttcg agatcaatgc ctccagcaaa gacccaagca gccagatgat
     1801 gcgtgccaag cggcagaggg accggaaagc tattaccagc tttcatcagg ggcggcagga
     1861 aaggcaggac ggcccagctg acccagtccc tcagagggag ctgcctcaga aggaagagga
     1921 ggacatggtt gagactgtgg agggtgtctt cacagaggtt gtgggccaga aacagccaag
     1981 gccaggaccc aaccaaggag ccaagaggcg gaggaaggag gccagtcagc gagaccagga
     2041 attttatgtc ccctaccggc ccaaggattt cgacagtgag cgggggctga gtgtcagtgg
     2101 ggctggaggg gcctttgagc agcaggtggc cggtgccgtc cttgatctga tgggggatga
     2161 agcccagaac atgagccgag ggcggcagca gctcaagtgg gaccggaaga agaagcggtt
     2221 tgtggggcag tcaggccaag aggacaagaa aaagatcaag acagagagtg gccggtttat
     2281 cagcagctct tacaagcgcg acctctacca gaagtggaag cagaagcaga aaattgatga
     2341 ccgggactcc gaggaagaag gaccatccaa ccggcgaggc cctgggcccc acagaggtgg
     2401 aaagcgaggt cgtagtcaag gtgcgtccca gtcccgagct tccagtgtac ccacaggcca
     2461 catgcgctcc gaactcaaga ccaaggaaca gatcctcaag cagcgccgtc aagcccagaa
     2521 gcagcgcttc ctgcagcgag ggggcctgaa gcagctttca gcacgcaacc gccgccgagc
     2581 ccaggagttg cgccagagcg cctttggccg gggtgctccc accaggaagg gcaagatgag
     2641 gaaaaggatg taaagagcca gactcagccc tggggcttcc tagtagccct ggtgcggaca
     2701 tcagggacat gtttccatgt gctgttggca gatccttcca cagaggagcc agtgtctatg
     2761 aggagcagtg ccacatggcc acagaaagca acaactgctt ttgactggga cactgggtgg
     2821 actcttagag gaggatgcat aggcgtctag ctatggaaag caggccgacc aagtcctgag
     2881 cctgcaagtc agctagctgc ttccatttct atgcattcag ggttcagaga ttggggccat
     2941 atggatgcct ccgactcagt attgagtttt aatgagtaaa ctttactgcc tctagtagac
     3001 caggagtgta gcttgcttag gatactggaa ggtgtctcag ctgaggctga gagcaagtgg
     3061 ccatgcctgt gtgtcgctcc tggccgccga atgaagaaaa tgagtggctg gatccacttg
     3121 cccatggcgg ctcagcacca ctgcagggca gaggaaggct gtgggtggct ttgccctctt
     3181 gcacatggaa gagagaacca gcctgtgcca tcctcgggtg cgccatcctg ctggtggctt
     3241 tcctcacctc ttgattgggg gtggagggtg gcaagcatcc tccagcagct ggaccccagt
     3301 gcagaccaaa aagcagatgg tgctgataat cacctcagac actgtgcaca gcaagggccc
     3361 gtcttggcat gcaccagccc tgtctgagct tgtccaatgc ccccagccag ctgggagagg
     3421 cccgtcccca gcctgtgtgg tgggtggagc gagcagcaca gctgcccacc ccattgtcta
     3481 cttaactgag ttcatactga gtgtcctgtg gaaggctcac aatggcgtga gctgccatgg
     3541 ctccatcttg ccaggagaaa ggagattcag agagcagttg tgttaagcct gcacaccaag
     3601 aaacgtggga cttggttcct cgggttccct tcactgttcg cctagtcggt ttaggaggca
     3661 gtctctgtgg gtttagcctt aggttggtca aagctggcca gtatggctga gacactcatg
     3721 ataaactgct tcacctgggg gcaggaacga catggtccga ttacatcctc tccctacccc
     3781 tacagaagga agcccagggc aggggcaggc tgggaaaccc cactggagag gcactggtag
     3841 tgtctagtcc agcctcttaa aagtttcctt tgttttactt attgataaag taactcaaac
     3901 ttgacctcta a
//
LOCUS       NM_001437305           14734 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 186 member A
            (Fam186a), transcript variant 1, mRNA.
ACCESSION   NM_001437305 XM_039080362
VERSION     NM_001437305.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 3, 2025 this sequence version replaced XM_039080362.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000007.1  132977874-132978184 c
            312-528             JAXUCZ010000007.1  132961323-132961539 c
            529-699             JAXUCZ010000007.1  132960820-132960990 c
            700-14086           JAXUCZ010000007.1  132942285-132955671 c
            14087-14279         JAXUCZ010000007.1  132938146-132938338 c
            14280-14428         JAXUCZ010000007.1  132934481-132934629 c
            14429-14608         JAXUCZ010000007.1  132933001-132933180 c
            14609-14734         JAXUCZ010000007.1  132922410-132922535 c
FEATURES             Location/Qualifiers
     source          1..14734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..14734
                     /gene="Fam186a"
                     /note="family with sequence similarity 186 member A"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
     exon            1..311
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    63..65
                     /gene="Fam186a"
                     /note="upstream in-frame stop codon"
     misc_feature    120..122
                     /gene="Fam186a"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MFK"
     CDS             129..14630
                     /gene="Fam186a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Protein FAM186A-like"
                     /codon_start=1
                     /product="family with sequence similarity 186 member A
                     isoform 1"
                     /protein_id="NP_001424234.1"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
                     /translation="MPVKKRGDFLIDSDSDDEVMDPITMRNPKGSKSLSLQFEIPESV
                     QAVINKIEQSQMIRAQEDVITKLSGIMTNVQLIMTRYNIDSLSPGRKVSISEVQKKTR
                     KVFLEKIATCVKNADIRERALSKTLSWLEEWNFVLSEVGAINMDEHYHWIAKVELMPE
                     MLKSINNNVDSMIRMILFLLEERKRLKKKSVARGTLWKVWKDRAIKRPATAQALRPDQ
                     MISDQIGLNAKVTEIQSMLQELISTSMFSKLENNAIKYMSATLLNLSKALNTVNEELR
                     LVSFRVARPFLHEDQGTEKDTDNSQQVIQELIEENEMLQEKLRESEEKCDQLIRVKNY
                     LGRPIHPSAPTLRTMVTLPLQVPYVSRDVHREEAGSEEQTDDSQKKGAKSTTVKWEPS
                     GGEVALAADMQQAEDRAVMTQDQKKLKGLPLTAETSDINLETAEKRTGQLAIPKAMEK
                     KKPSKQKAQEVKGTPSVLWEQLGKGKSEQLLRSSPGSPGSRESTLKLPDKDAKSEVEL
                     MQTESSPEVQKPETKWKKVAAKTGVLASAKQSGKAKTPKGTSETPEESEQGSLESFQR
                     AILAFLREKSSNIGKAFDPKSIRKEELSLGRTEVEKLNIIRDQMEEYFQRVAETVTAA
                     LRTYKDEKRAQLKEKAKKPSKVALGTPRMLPKQGAGSAKSEVGRVLLSEITDPPIRKL
                     VLMLLEEIDSESTFKRTKEQQGVEAGAGKEEPRLKPKDRAQLLETWGQAFKAPVASQV
                     QDRLGRDAEDAEKLRKRERSHLDILKATRQSSISLIPKSPMKTPKSQRSQVQVLPVEP
                     GAMGAAEEEQPKLSPFSSRASLLSAKPPPMHVLEQVEMAGHDIAKLSGASLTPEQAQP
                     LTGPLTGEHTVELETAFIAGQEQHLGTKLMVPRTLEPTQTPKGSLTAEEPQAVRISQV
                     TTEQIPGVTGTQRTVLPSQEVQVKDRILTSKQTLEQEITLIPEQDKGPRITLTPQQTQ
                     ALGITLTSEQTKAQRISLTHEQARALGIMLTPEQYQEERLSLTPQQAQILGLTLDLQQ
                     AKALGITLTPEQTKAQRVSLIPQQSQALEATLTAQQAEAQRINLTPEQAEVLGLSLTP
                     QPIIHAPEQAEVLGLSLTPQPIIHAPEQAEVLGLSLTPQPITLYPEQAQALGITPTPQ
                     PITLYPEQTQVPGITPTPQPITRAPEQAQAPGITPTPQPITHAPEQTQAPGITPTPQP
                     ITRAPEQTQAPGITPTPQPITFNPEQARVLAINLIDEQVSLSPQQAKALGITPTPQMT
                     TLTPEQTQALGITPTPQLITLYPEQAQAPGITPTPQPITLAPEQAQAPGITPTPQPIT
                     LSPEQARVLAINLIDEQVSLSPQQAKALGITPTPQMTTLTPEQTQALGITPMPQPITL
                     YPEQAQAPGITPTPQPITLYPEQAQAPGITPTPQPITRAPEQAQAPGITPTPQPITRA
                     PEQAQAPGITPNSQPITRAPEQAQAPGITPTPQPITRAPEQTQAPGITPTPQPITFTP
                     EQAQAPGITPTPQPITHAPEQTQAPGITRTPQPITRAPEQTQAPGITRTPQRITRAPE
                     QAQAPGITPTPQRITRAPEQAQAPGITPTPQPITRAPEQAEAPGITRTPQPITRAPEQ
                     AQAPGITRIPQPITRAPEQAQAPGITRTPQPITRAPEQAQAPGITPTPQPITRAPEQT
                     QAPGITPTPQPITFNPEQARVLAINLIDEQVSLSPQQAKALGITPTPQMTTLTPEQTQ
                     ALGITPTPQPITLYPEQAQAPGITPTPQPITLSPEQAQAPGITPTPQQITRAPEQAQA
                     PGITPTPQPITLSPEQARVLAINLIDEQVGLSPQQAKALGITPTPQMTTLTPEQTQAL
                     GITPTPQPITLSPEQAQAPGITPTPQPITLSPEQAQAPGITPTPQPTTLYPEQTQAPG
                     ITRIPQPITRAPEQAQAPGITPTPQPITRAPEQTQALGITPTPQPITFTPEQAQAPGI
                     TPTPQPITHAPEQTQALGITPTPQPITFTPEQAQVLSVTPTLQPITFTPEQAQALGIT
                     PTPQPVTLTPKQNQALAIALTAEQVKTQSVSLSPKQTQALGITPTPQPITFTPDQTQA
                     LGITPTPQPITLSPEQARVLAINLIDEQVSLSPQQAKALGITPTPQMTTLTPEQTQAL
                     GITPTPQPITLYPEQVQALGITPTPQPITLSPEQAQALAITPTPPPITLAPEQTEALG
                     ITPTPQPITLSPEQVQALGITSTPEPITLDPEQAQALGIIPTPQPITLAPEQTEALGI
                     TPTPPPITLTPEEIQNLGISLIPKQQEISLSPQQAEALGLTITPQQAQVQKIYFTPLQ
                     AQALGIRLSPDQAETLKISLTPEQAHSLGIILTVEQAKAQRINLTPQQAEDLGLTLTP
                     EQAQDLGVYLIPKRQQISLSPQQAQALGLTLTPQQAQVQKIYLTAPQAQALGIILNPE
                     QAKTLNISLTPEEAHSLGLTLTLDQAKAQRVSLTPQQAEDLGITLTPEQAQDLGISLI
                     PKEREISFSPEQAQALGLTLTPQQAQVEKIYLTPQHAQALGIRLSPEQAKTMKISLSP
                     EQAQSLGIILTVEQAKAQKINLTLQQAEDLGLTLTPEQAQDLGVSLIPKEQEISFSPE
                     QAQALGLTLTPQQAQVEKIYLNPQQAQALGIKLSPEQAKTMKISLSPEQAQSLGIILT
                     VEQAKAQKINLTLQQAEDLGLTLTPEQTQDLGVYLIPKEQEISLSPEQAQALGLTLTP
                     QQAKAQKIYLTPQQAQALGIKLSPEQAKTRGFSLTSEQAQDLGIILTVEQAKAQRINL
                     TLRQAEDLGLTLTSEQAEALGITPSPRQAEALGITPSPGQAEALGITPTPWEAEALGI
                     TPTPWEAEALGIAPTPRQAEALGIAPTPEQAEALGIAPTPEQAEALGIAPTPRQAEAL
                     GITPSPGQAEALGITPTPGQAKALGVAPSKRQAKALRIAPTPRQAKALGVAPTPRQAE
                     PLGITPIPWEAEDLGLTLTPEQAQDLGVSLIPKEQEISLSPEQAQALGLTLTPQQAKA
                     QKIYLTPQQAQALGIKLSPEQAKTMKISLSPEQAQSLGIILTVEQAKAQKINLTLQQA
                     EDLGLTLTPEQAQDLGVSLIPKEQEISFSPEQAQALGLTLTPQQAQVEKIYLNPQQAQ
                     ALGIRLSPEQAKTMKISLSPEQAQSLGIILTVEQAKAQKINLTLQQAEDLGLTLTPEQ
                     AQDLGVSLIPKEQEISFSPEQAQALGLTLTPQQAQVEKIYLNPQQAQALGIRLSPEQA
                     KTMKISLSPEQAQSLGIILTVEQAKAQKINLTLQQAEDLGLTLTPEQAQDLGVSLIPK
                     EQEISFSPEQAQALGLTLTPQQAQVEKIYLNPQQAQALGIKLSPEQAKTMKISLSPEQ
                     AQSLGIILTVEQAKAQKINLTLQQAEDLGLTLTPEQTQDLGVSLIPKEQEISLSPEQA
                     QALGLTLTPQQAKAQKIYLTPQQAQALGIKLSSEQAKTMKISLSPEQAQSLGIILTVE
                     QAKAQKINLTLQQAEDLGLTLTPEQAQDLGVYLIPKEQEISLSPEQAQALGLTLTPQQ
                     AKAQKIYLTPQQAQALGIKLSPEQAKTMKISLSPEQAQSLGIILTVEQAKAQRINLTL
                     RQAEDLGLTLTSEQAEALGITLSPGQAEALGIAPTPGQAEALGVAPTPRQAEALRITP
                     SPRQAEALGITPSPRQAEGLGITPSPRQAEALGIAPTPEQAEALGIAPTPRQAKALRI
                     APTPRRAKALGITPSPGQAKALGITPSPGQAKALGITPSPKQAEALGITPSPKQAEAL
                     GITPSPGQAKALGITPSPGQAKTLGITPSPGQAKALGITPSPGQAAALGITPSPGQAK
                     ALGITPSPKQAEALGITPSPKQTEALGITPSPGQAKALGITPSPGQAKTLGITPSPGQ
                     AKALGITPSPEPGKESLGLTPEQVQALSTSFFPKETQSLGIYLTPKQAWKLGITLTTT
                     QAKVMKISLTPEQAQALGITFTPEQAKARRTSLTPEQAQALGVALTPQQAKAQRITLT
                     PEQAQGLGVALTPEQALALGIALIPDNAQAQGILSLRKSQDLDVPLTHKQAEALRSRF
                     SVKQLEALGTQRLISESVQMPKPAVASKQTQTIGIPLTTQLSQGLGVPLTKRQDTAVG
                     ISPLLPRQTQAFEPAQAKQPPLRPRQAPPWQDQLAPGLTKTLVFTISLQKAWNLGLTF
                     TYEQMQAAAVTLTSEQVAALEDALTEAMAWRWETLVTPERVQAASNITAKHLQALGAT
                     ARQSVQAFRTPFTLERPAALVPSTDWPPLTQAPFPLTTSLGVSILPDSEKPRMSPPYR
                     QTLADRGQGVPAQVQGPEEVPPSSRQLLAPGAPPTPGPPLGPKHFFKPKDTWPPLVSE
                     PYFPHRTPPASRVPPTSGEAPGLVSGDTAAQKELLVSRTSLFQPPAFREQAPSPAPEW
                     QEPSWTIPMQGLVPISSSFPLHPSTAEALPTPGRSQRIPPSSTTQRSSEAKPLKPKSA
                     RALPGVALGFEASPAPFPIEKTQVPKVSDTSEQTQVLQGSFDMQPFGIFQPYVTSSRI
                     PRSQSPLTGEKALSREKPGIPLPSLTTQLPQTQQILPSEKSQKPQLPPIDKPWTPTPV
                     SGTREAKMMVPPFTDQHSEDRYVIDVEAQRKNLVTLNQAAQTSGLPEQYLTVAKNLII
                     ELLHIDTVRLGYLSRKYVAYRLIQLARNHLSKRVKTIQNTGKGYELQNLYIMLNRIDQ
                     YQKKVMQGWTDKQKHLEQRRRQCLWTMTQFFSQLERVFKLNLSQPMPSISSFKKIPKF
                     TKLQRPVLDLLIDDSKRSDVFKRRGQAPVEAVWNADLSTSSYPVVEKTPMNLLWAQLG
                     GYPDIPKLLQLDIQSTLRKSLASICPRSKKIRK"
     misc_feature    <993..1112
                     /gene="Fam186a"
                     /note="GvpT/GvpP family gas vesicle accessory protein;
                     Region: GvpT; NF041669"
                     /db_xref="CDD:469551"
     misc_feature    <993..1112
                     /gene="Fam186a"
                     /note="GvpT/GvpP family gas vesicle accessory protein;
                     Region: GvpT; NF041669"
                     /db_xref="CDD:469551"
     misc_feature    <1212..2402
                     /gene="Fam186a"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <1212..2402
                     /gene="Fam186a"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <3555..4637
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <3555..4637
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <4209..5969
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <4209..5969
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5292..6869
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5292..6869
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <8334..>8996
                     /gene="Fam186a"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    <8334..>8996
                     /gene="Fam186a"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    9138..>10922
                     /gene="Fam186a"
                     /note="exonuclease SbcC; Region: sbcc; TIGR00618"
                     /db_xref="CDD:129705"
     misc_feature    9138..>10922
                     /gene="Fam186a"
                     /note="exonuclease SbcC; Region: sbcc; TIGR00618"
                     /db_xref="CDD:129705"
     misc_feature    <10794..>11732
                     /gene="Fam186a"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    <10794..>11732
                     /gene="Fam186a"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    <12867..13877
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <12867..13877
                     /gene="Fam186a"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            312..528
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            529..699
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            700..14086
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            14087..14279
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            14280..14428
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            14429..14608
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            14609..14734
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cataacctca ggactccttg aggcttccta gtggacgctt attagcattc gcctagattc
       61 tgtgaagaag aaaaaaaaaa aagaagaaga agaagaagaa atacaaagaa atcacccaaa
      121 tgtttaaaat gcctgtcaaa aagcgaggtg atttcttgat tgactctgat tcagacgatg
      181 aggtcatgga tcccatcacc atgagaaatc ccaaaggcag taagtcactg agcttgcaat
      241 ttgaaattcc agagtcagta caggcagtca tcaataagat tgagcaatcg cagatgattc
      301 gggcccaaga ggatgttatt acaaagctga gtggaattat gaccaacgtg cagctgataa
      361 tgacccggta taatattgac agcctgtccc ctgggaggaa ggtctccatc tcggaagtcc
      421 agaaaaagac gagaaaggtt ttcttagaaa agattgccac ttgtgtgaag aatgctgaca
      481 taagagaaag ggctctctcc aagactctgt cctggctgga agaatggaat tttgttctgt
      541 ctgaggtggg cgccatcaac atggatgagc actaccactg gatcgccaag gtggagttga
      601 tgccggaaat gctgaagagc atcaacaata atgtggattc catgatccga atgatcttat
      661 tcctcctcga agaaaggaag aggctaaaga aaaagtcagt ggccagaggc actctctgga
      721 aagtgtggaa agaccgggct ataaagcggc ctgccacggc gcaggcttta aggccagatc
      781 agatgatttc cgaccagatt ggcctaaatg cgaaggttac agagatccaa agcatgctgc
      841 aggagctcat cagtacctcc atgttcagca agctggagaa caatgccatt aaatacatgt
      901 ctgcgacgct gctcaatctc tccaaggcct tgaataccgt caacgaagag ctcagactcg
      961 tgagctttcg agttgccagg ccgtttctcc acgaagacca agggacagag aaagatacag
     1021 acaactccca gcaagtcatc caagaactca ttgaagagaa cgagatgctt caggagaaac
     1081 ttagagaatc cgaagaaaaa tgtgaccaac ttattcgcgt caaaaactat ctcggacgcc
     1141 cgatacatcc ctcagctccg accttgagga cgatggttac gctgcctctg caggtcccgt
     1201 acgtcagcag agatgtccac agggaggagg ctggcagtga ggaacagact gatgactccc
     1261 agaagaaggg ggctaaaagc accacagtaa agtgggaacc atctgggggt gaagtggccc
     1321 tggctgcaga tatgcagcaa gccgaggaca gagctgtgat gacccaggac cagaagaaac
     1381 tcaaaggcct accactgacg gctgagacct cagacataaa tctggaaacg gcggaaaaga
     1441 gaactggtca gcttgctatt ccaaaagcaa tggaaaagaa gaaaccaagt aaacagaagg
     1501 cccaggaagt caaaggcaca ccgagtgtcc tgtgggaaca actcgggaag gggaaatcgg
     1561 agcagctgct tcggagcagc ccaggctcgc cagggagtag agagtccacc ctgaagttac
     1621 cagacaaaga tgccaagagt gaggtagaac tgatgcaaac tgagagttcc ccagaggtac
     1681 aaaaaccgga aacaaagtgg aaaaaagtag cagcaaaaac cggagtgtta gcctctgcaa
     1741 aacaatctgg taaagctaag acccctaagg ggacttcaga gacccccgaa gaaagtgagc
     1801 agggcagtct agaatcattt caaagggcca tcctggcttt cctgagagag aagagtagta
     1861 acataggaaa ggcttttgat ccaaagagta tacggaaaga ggagttgtca ctgggaagaa
     1921 cggaagttga aaaattaaac atcataaggg atcaaatgga ggaatatttc caaagagtgg
     1981 cagagactgt gaccgcagcc ttgaggacat acaaggatga gaaaagggca caacttaaag
     2041 agaaggccaa gaaaccgtca aaggtggcgc tgggtacacc ccggatgctt cctaagcagg
     2101 gggcaggcag cgccaagtct gaagtcggca gagttctcct cagtgagatc acagacccac
     2161 caattaggaa actggtcctg atgctactag aagagataga cagtgagtcc acattcaaaa
     2221 ggacaaagga gcagcaaggg gtggaggcgg gggcagggaa ggaggagcca agactgaagc
     2281 cgaaggacag agcacagctg ctggagacgt ggggacaagc attcaaagca ccagttgcca
     2341 gccaggttca ggaccgtctg gggagagatg cggaagatgc tgagaagctg aggaagaggg
     2401 agcggagtca tctggacata ttgaaagcca ccagacaatc ctcgataagt ttaattccta
     2461 agtcgccaat gaagacccca aaatcgcaga gaagtcaggt gcaggtgctc cctgtggagc
     2521 ctggtgcaat gggggccgcc gaggaagagc agcccaaact gtctcccttc tcttccaggg
     2581 cctcccttct ttctgcgaag ccccccccaa tgcatgttct tgagcaggtg gagatggcgg
     2641 gccatgacat agctaagctt tcaggagcat ccctcacccc cgagcaggca caacctttga
     2701 cgggtcctct tactggtgaa cacactgtag aattagagac tgctttcata gcagggcagg
     2761 agcagcactt ggggactaag ctgatggttc ctaggactct tgagccaaca cagactccaa
     2821 agggctctct cacagcagaa gaaccccagg cagtgcgaat ctcccaagtg actactgaac
     2881 agatacctgg ggtcacaggc acccaaagaa cagttctccc ctcccaggag gttcaagtaa
     2941 aagatagaat tctcacctcc aagcagaccc tggaacaaga aatcactctc atccctgagc
     3001 aagacaaggg gccaaggatc actctcaccc ctcagcagac ccaggcccta ggcatcactc
     3061 ttacctctga gcagactaag gcccagagga tcagtctgac tcacgagcag gctcgggccc
     3121 ttgggatcat gctcactcct gagcagtacc aagaagagag acttagtctg actcctcagc
     3181 aggcccagat cctgggactc actctcgacc ttcagcaggc taaggccctg ggaatcaccc
     3241 tcacccctga gcagaccaag gcacagaggg tcagtctgat cccgcaacag tcccaggccc
     3301 tggaagccac tctcaccgct cagcaggctg aagcacaaag aattaatctc accccggagc
     3361 aggctgaggt cctggggctc tctctgaccc ctcagcctat cattcatgca cctgagcagg
     3421 ctgaggtcct ggggctctct ctgacccctc agcctatcat tcatgcacct gagcaggctg
     3481 aggtcctggg gctctctctg acccctcagc cgatcactct ctaccctgag caggcccagg
     3541 ccctgggtat caccccaaca cctcagccga tcactctcta ccctgagcag acccaggtcc
     3601 cgggtatcac cccgacccct cagccgatca ctcgggcccc tgagcaggcc caggccccgg
     3661 gtatcacccc aacccctcag ccgatcactc acgcccctga gcagacccag gccccgggta
     3721 tcaccccgac ccctcagccg atcactcgcg cccctgagca gacccaggcc ccgggtatca
     3781 ccccgacccc tcagccgatc actttcaacc ctgagcaggc ccgggtcctg gcgatcaatc
     3841 tcattgatga gcaggtcagt ctgagccctc aacaggccaa ggctctgggt atcactccta
     3901 cccctcagat gaccactctc actcctgaac agactcaggc cctgggtatc accccaacgc
     3961 ctcagctgat cactctctac cctgagcagg cccaggcccc gggtatcacc ccgacccctc
     4021 agccgatcac tctcgcccct gagcaggccc aggccccggg tatcaccccg acccctcagc
     4081 cgatcactct ctcccctgag caggcccggg tcctggcgat caatctcatt gatgagcagg
     4141 tcagtctgag ccctcaacag gccaaggctc tgggtatcac tcctacccct cagatgacca
     4201 ctctcactcc tgaacagact caggccctgg gtatcactcc aatgcctcag ccgatcactc
     4261 tctaccctga gcaggcccag gccccgggta tcaccccgac tcctcagccg atcactctct
     4321 accctgagca ggcccaggcc ccgggtatca ccccaacccc tcagccgatc actcgcgccc
     4381 ctgagcaggc ccaggccccg ggtatcaccc caacgcctca gccgatcact cgcgcccctg
     4441 agcaggccca ggccccgggt atcaccccga actctcagcc gatcactcgt gcccctgagc
     4501 aggcccaggc cccgggtatc accccaacgc ctcagccgat cactcgcgcc cctgagcaga
     4561 cccaggcccc gggtatcacc ccgacccctc agccgatcac tttcacccct gagcaggccc
     4621 aggccccggg tatcaccccg acccctcagc caatcactca cgcccctgag cagacccagg
     4681 ccccgggtat cacccggacc cctcagccga tcactcgcgc ccctgagcag acccaggccc
     4741 cgggtatcac ccggacccct cagcggatca ctcgcgcccc tgagcaggcc caggccccgg
     4801 gtatcacccc gacccctcag cggatcactc gcgcccctga gcaggcccag gccccgggta
     4861 tcaccccgac ccctcagccg atcactcgcg cccctgagca ggccgaggcc ccgggtatca
     4921 cccggacccc tcagccgatc actcgcgccc ctgagcaggc ccaggccccg ggtatcaccc
     4981 ggatccctca gccgatcact cgcgcccctg agcaggccca ggccccgggt atcacccgga
     5041 cccctcagcc gatcactcgt gcccctgagc aggcccaggc cccgggtatc accccgaccc
     5101 ctcagccgat cactcgcgcc cctgagcaga cccaggcccc gggtatcacc ccgacccctc
     5161 agccgatcac tttcaaccct gagcaggccc gagtcctggc gatcaatctc attgatgagc
     5221 aggtcagtct gagccctcaa caggccaagg ctctgggtat cactcctacc cctcagatga
     5281 ccactctcac tcctgaacag actcaggccc tgggtatcac cccaacgcct cagccgatca
     5341 ctctctaccc tgagcaggcc caggccccgg gtatcacccc aacccctcag ccgatcactc
     5401 tctcccctga gcaggcccag gccccgggta tcaccccgac ccctcagcag atcactcgcg
     5461 cccctgagca ggcccaggcc ccgggtatca ccccgacccc tcagccgatc actctctccc
     5521 ctgagcaggc ccgggtcctg gcgatcaatc tcattgatga gcaggtcggt ctgagccctc
     5581 aacaggccaa ggctctgggt atcactccta cccctcagat gaccactctc actcctgaac
     5641 agactcaggc cctgggtatc accccaacgc ctcagccgat cacactctcc cctgagcagg
     5701 cccaggcccc gggtatcacc ccgacccctc agccgatcac tctctcccct gagcaggccc
     5761 aggccccggg tatcaccccg actcctcagc cgaccactct ctaccctgag cagacccagg
     5821 ccccgggtat cacccggatc cctcagccga tcactcgcgc ccctgagcag gcccaggccc
     5881 cgggtatcac cccgacccct cagccgatca ctcgcgcccc tgagcagacc caggccctgg
     5941 gtatcacccc gacccctcag ccaatcactt tcacccctga gcaggcccag gccccgggta
     6001 tcaccccgac ccctcagccg atcactcacg cccctgagca gacccaggcc ctgggtatca
     6061 ccccgacccc tcagccgatc actttcaccc ctgagcaggc ccaggtcctg agtgtcactc
     6121 ctactcttca gccaatcact ttcacccctg agcaggccca ggccctgggt atcaccccga
     6181 cccctcagcc agtcactctc acccctaagc agaaccaggc cctggcaatc gctctcactg
     6241 ctgagcaggt caagactcag tcagtcagtc tgagcccgaa gcagactcag gccctgggta
     6301 tcaccccaac ccctcagcca ataactttca cccctgatca gacccaggcc ctgggtatca
     6361 ccccaacccc tcagccgatc actctctccc ctgagcaggc ccgggtcctg gcgatcaatc
     6421 tcattgatga gcaggtcagt ctgagccctc aacaggccaa ggctctgggt atcactccta
     6481 cccctcagat gaccactctc actcctgaac agactcaggc cctgggtatc accccaacgc
     6541 ctcagccgat cactctctac cctgagcagg tccaggccct gggtatcacc ccgacccctc
     6601 agccgatcac tctctcccct gagcaggccc aggccctggc tatcactccg accccaccac
     6661 caatcactct tgcccctgag cagacagaag ctctgggtat caccccgacc cctcagccaa
     6721 ttactctttc ccctgagcag gtccaggccc tgggtattac ttctacccct gagccgatca
     6781 ctctcgaccc tgagcaggcc caggccctgg gtatcatccc gacccctcag ccgatcactc
     6841 tcgcccctga gcagacagaa gccctgggta tcaccccgac cccaccaccg atcactctca
     6901 cccctgagga gatccaaaac ctggggattt ctctcattcc caaacaacag gagatcagtc
     6961 ttagtcccca gcaggccgaa gctcttgggc ttactattac ccctcagcag gctcaagtac
     7021 agaagattta tttcacccct ctgcaggccc aagctctggg tatcagactc agccctgacc
     7081 aggccgagac actgaagatc agtcttaccc ctgagcaggc ccattctctg ggcatcattc
     7141 tcacagttga gcaggccaag gcccagagga ttaatctgac ccctcagcag gctgaggact
     7201 tgggactcac tctcacccct gagcaggccc aggacctagg ggtttatctc attcccaaac
     7261 gacagcagat cagtcttagt ccccagcagg cccaagctct cgggctcact ctcacccctc
     7321 agcaggctca ggtacagaag atttatctga ctgctccgca ggcccaagct ctgggtatca
     7381 ttctcaaccc tgagcaggcc aagacactga atatcagtct tacgcctgag gaggcccact
     7441 cactaggcct cactctcaca cttgaccagg ccaaggcaca gagggtcagt ctgacccctc
     7501 agcaggctga ggacttggga ataactctca cccctgagca ggcccaggac ctagggattt
     7561 ctctcattcc taaagaacgg gagataagtt tcagtcctga gcaggcccaa gctctggggc
     7621 tcactctcac ccctcagcag gctcaagtag agaagattta tctcacccct cagcatgccc
     7681 aagctctggg tatcagactc agccctgagc aggccaagac aatgaagatc agtcttagcc
     7741 ctgagcaagc ccaatctctg ggcatcattc tcacagttga gcaggccaag gcccagaaga
     7801 ttaatctgac ccttcagcag gctgaggact tgggactcac tctcacccct gagcaggccc
     7861 aggacctagg ggtttctctc attcctaaag aacaggagat aagtttcagt cctgagcagg
     7921 cccaagctct ggggctcact ctcacccctc agcaggctca agtagagaag atttatctca
     7981 accctcagca ggcccaagct ctgggtatca aactcagccc tgagcaggcc aagacaatga
     8041 agatcagtct tagccctgag caagcccaat ctctgggcat cattctcaca gttgagcagg
     8101 ccaaggccca gaagattaat ctgacccttc agcaggctga ggacttggga ctcactctca
     8161 cccctgagca gacccaggac ctaggggttt atctcatacc taaagaacag gagatcagtc
     8221 ttagtcctga gcaggcccaa gctctggggc tcactctcac ccctcagcag gccaaggcac
     8281 agaagattta tctcacccct cagcaggccc aagctctggg tatcaaactc agccctgagc
     8341 aggccaagac acgggggttc agtcttacct ctgagcaggc ccaagatttg ggcatcattc
     8401 ttacagttga gcaggccaag gcccagagga ttaatctgac ccttcggcag gctgaggact
     8461 tgggactcac tctcacctct gagcaggctg aggccttggg aataactcct tccccacggc
     8521 aggctgaggc cttgggaata actccttccc ctgggcaggc tgaggccttg ggaataactc
     8581 ctaccccatg ggaggctgag gccttgggaa taactcctac cccatgggag gctgaggcct
     8641 tgggaatagc tcctactcct aggcaggctg aggccttggg aatagctcct actcctgagc
     8701 aggctgaggc cttgggaata gctcctaccc ctgagcaggc tgaggccttg ggaatagctc
     8761 ctactcctag gcaggctgag gccttgggaa taactccttc ccctgggcag gctgaggcct
     8821 tgggaataac tcctacccct gggcaggcta aagccttggg agtagctcct tccaaacggc
     8881 aggctaaggc cttgagaata gctcctactc ctaggcaggc taaggccttg ggagtagctc
     8941 ctactcctag gcaggctgag cccttgggaa taactcctat cccatgggag gctgaggact
     9001 tgggactcac tctcacccct gagcaggccc aggacctagg ggtttctctc attcctaaag
     9061 aacaggagat cagtcttagt cctgagcagg cccaagctct ggggctcact ctcacccctc
     9121 agcaggccaa ggcacagaag atttatctca cccctcagca ggcccaagct ctgggtatca
     9181 aactcagccc agagcaggcc aagacaatga agatcagtct tagccctgag caagcccaat
     9241 ctctgggcat cattctcaca gttgagcagg ccaaggccca gaagattaat ctgacccttc
     9301 agcaggctga ggacttggga ctcactctca cccctgagca ggcccaggac ctaggggttt
     9361 ctctcattcc taaagaacag gagataagtt tcagtcctga gcaggcccaa gctctggggc
     9421 tcactctcac ccctcagcag gctcaagtag agaagattta tctcaaccct cagcaggccc
     9481 aagctctggg tatcagactt agccctgagc aggccaagac aatgaagatc agtcttagcc
     9541 ctgagcaagc ccaatctctg ggcatcattc tcacagttga gcaggccaag gcccagaaga
     9601 ttaatctgac ccttcagcag gctgaggact tgggactcac tctcacccct gagcaggccc
     9661 aggacctagg ggtttctctc attcctaaag aacaggagat aagtttcagt cctgagcagg
     9721 cccaagctct ggggctcact ctcacccctc agcaggctca agtagagaag atttatctca
     9781 accctcagca ggcccaagct ctgggtatca gactcagccc tgagcaggcc aagacaatga
     9841 agatcagtct tagccctgag caagcccaat ctctgggcat cattcttaca gttgagcagg
     9901 ccaaggccca gaaaattaat ctgacccttc agcaggctga ggacttggga ctcactctca
     9961 cccctgagca ggcccaggac ctaggggttt ctctcattcc taaagaacag gagataagtt
    10021 tcagtcctga gcaggcccaa gctctggggc tcactctcac ccctcagcag gctcaagtag
    10081 agaagattta tctcaaccct cagcaggccc aagctctggg tatcaaactc agccctgagc
    10141 aggccaagac aatgaagatc agtcttagcc ctgagcaagc ccaatctctg ggcatcattc
    10201 tcacagttga gcaggccaag gcccagaaga ttaatctgac ccttcagcag gctgaggact
    10261 tgggactcac tctcacccct gagcagaccc aggacctagg ggtttctctc attcctaaag
    10321 aacaggagat cagtcttagt cctgagcagg cccaagctct ggggctcact ctcacccctc
    10381 agcaggccaa ggcacagaag atttatctca cccctcagca ggcccaagct ctgggtatca
    10441 aactcagctc tgagcaggcc aagacaatga agatcagtct tagccctgag caagcccaat
    10501 ctctgggcat cattcttaca gttgagcagg ccaaggccca gaaaattaat ctgacccttc
    10561 agcaggctga ggacttggga ctcactctca cccctgagca ggcccaggac ctaggggttt
    10621 atctcattcc taaagaacag gagatcagtc ttagtcctga gcaggcccaa gctctggggc
    10681 tcactctcac ccctcagcag gccaaggcac agaagattta tctcacccct cagcaggccc
    10741 aagctctggg tatcaaactc agccctgagc aggccaagac aatgaagatc agtcttagcc
    10801 ctgagcaagc ccaatctctg ggcatcattc tcacagttga gcaggccaag gcccagagga
    10861 ttaatctgac ccttcggcag gctgaggact taggactcac tctcacctct gaacaggctg
    10921 aggccttggg aataactctt tcccctgggc aggctgaggc cttgggaata gctcctaccc
    10981 ctgggcaggc tgaggccttg ggagtagctc ctaccccacg gcaggctgag gccttgagaa
    11041 taactccttc cccaaggcag gctgaggcct tgggaataac tccttcccca aggcaggctg
    11101 agggcttggg tataactcct tccccacggc aggctgaggc cttgggaata gctcctaccc
    11161 ctgagcaggc tgaggccttg ggaatagctc ctaccccaag gcaggctaag gccttgagaa
    11221 tagctcctac tcctaggcgg gctaaagcct tgggaataac tccttcccct gggcaggcta
    11281 aagccttggg aataactcct tcccctgggc aggctaaagc cttgggaata actccttccc
    11341 ctaagcaggc tgaggccttg ggaataactc cttcccctaa gcaggctgag gccttgggaa
    11401 taactccttc ccctgggcag gctaaagcct tgggaataac tccttcccct ggacaggcta
    11461 aaaccttggg aataactcct tcccctgggc aggctaaagc cttgggaata actccttccc
    11521 ctgggcaggc tgcggccttg ggaataactc cttcccctgg gcaggctaaa gccttgggaa
    11581 taactccttc ccctaagcag gctgaggcct tgggaataac tccttcccct aagcagactg
    11641 aggccttggg aataactcct tcccctgggc aggctaaagc cttgggaata actccttccc
    11701 ctgggcaggc taaaaccttg ggaataactc cttcccctgg gcaggctaaa gccttgggaa
    11761 taactccttc ccctgagcct ggcaaagaaa gtttaggtct gacccctgag caagttcagg
    11821 ccttgagtac cagtttcttc cctaaggaaa cccagtcctt gggaatttat ctcaccccaa
    11881 agcaggcctg gaaattgggg atcactctta ctactactca agccaaggta atgaagatta
    11941 gtttgacccc tgagcaggcc caggccctgg ggatcacttt cacccctgag caggccaagg
    12001 cacggaggac cagtctgacc cctgagcagg cccaggctct gggggtcgca ctcacacctc
    12061 agcaggccaa ggcccagagg atcactctca ccccagagca ggcccagggc ctgggggtcg
    12121 ctctcactcc tgagcaggcc ctggccctgg ggattgctct catccccgat aatgcccagg
    12181 cacaaggtat tctttctctc aggaaatccc aggatttgga tgttccatta actcataaac
    12241 aagcagaagc actaaggagc cgtttttctg tgaagcaact tgaagccctg ggaacccaaa
    12301 gacttatctc tgagtctgtc caaatgccaa agccagctgt cgcttctaaa cagacccaga
    12361 caattggaat cccactaact actcaactgt cccagggact tggagttcca cttacaaaga
    12421 gacaggacac agcagtgggg atctctcccc tccttcccag gcagacccag gcatttgagc
    12481 ctgcccaggc aaagcagcct cccctcagac ccaggcaggc cccaccatgg caggaccagc
    12541 ttgctccagg gctcacaaag acactggtat tcaccatcag tctccagaaa gcctggaact
    12601 tgggtctcac ttttacctat gaacaaatgc aggcagcagc ggtcaccctc acctctgagc
    12661 aggtggcagc attagaagat gctctcactg aggcaatggc ttggagatgg gagactttag
    12721 tcacaccaga aagggttcaa gcggcatcaa acattactgc taagcatctg caagcactgg
    12781 gagctactgc tcgtcagtca gttcaggcat ttcgcactcc ttttaccttg gaaaggcctg
    12841 ccgcattggt tccttccact gactggcctc ctctcactca agccccattt ccccttacga
    12901 caagcctagg agtgagtatt cttccagact ctgagaagcc acggatgtct cctccctaca
    12961 gacagactct tgcagacagg ggccaaggcg ttcctgcaca ggtccaagga ccagaagaag
    13021 tccctccttc cagtagacag ctcctagcac ctggggctcc tcccactcca gggcctcctc
    13081 tgggccctaa gcacttcttc aaaccaaaag acacttggcc acctctagta tcagaaccct
    13141 acttccccca ccgaacacct cctgcgtcta gagtcccacc cacctctgga gaggcgccag
    13201 gacttgtttc tggagacact gctgcccaga aggagctcct ggtttccaga acctccctct
    13261 tccagcctcc tgccttccgt gagcaagctc cctctcctgc ccctgaatgg caagagccat
    13321 cgtggaccat tcccatgcaa gggttggtac caataagctc ctccttcccg ctgcatccct
    13381 ccacagcaga ggccctccca acccctggaa gatctcagag aattcccccc tcttcaacca
    13441 ctcagagaag ttcagaagcc aaacctctaa aacctaagtc agcgagagct cttccgggtg
    13501 ttgctctggg ttttgaggcc tctccggctc ctttccctat cgagaagacc caagtaccta
    13561 aggtttctga cacttcagaa caaactcaag tactccaagg ttcttttgac atgcaaccat
    13621 ttggaatatt tcagccttat gtcaccagct ccaggatacc acggtcacag tcccctctca
    13681 ctggtgagaa agccctttcc agagagaagc ctggaatacc actaccgtct ctcaccactc
    13741 aactccccca aacacaacag atcttacctt ctgaaaagag ccagaaacca cagctccccc
    13801 cgatagacaa gccctggaca ccaacccctg tttctggtac cagagaagcc aagatgatgg
    13861 tgcccccttt cactgatcag cactctgagg acagatatgt cattgatgtg gaggctcaga
    13921 ggaagaatct ggtcacatta aatcaggctg cacaaacttc tggactccct gaacaatatc
    13981 tcacagttgc caagaatctc atcatcgaat tgcttcatat agatacagtt cggctagggt
    14041 atctgtcccg caagtatgtt gcctataggc tgatccagct tgccagaaac cacctaagca
    14101 aacgagtgaa aaccatccaa aacactggga aagggtatga gcttcagaac ttgtacatca
    14161 tgctgaacag aatcgatcag taccagaaga aggtaatgca gggttggaca gacaaacaga
    14221 aacatctgga gcagagacga aggcagtgcc tatggactat gacgcagttc ttcagccagc
    14281 ttgagagggt gtttaaacta aatcttagcc agcccatgcc ctccatctcc agctttaaga
    14341 agatacccaa attcaccaaa cttcaacggc cggtcttgga cttattgatt gatgacagca
    14401 aaagatccga tgttttcaaa agacgtgggc aagccccagt ggaggctgtg tggaatgctg
    14461 acctgtctac atcaagctac ccagtggtag agaaaacacc aatgaatcta ctctgggccc
    14521 agctgggcgg gtacccagat attcccaaac tgctgcagtt agatattcag tcgaccttaa
    14581 gaaaatctct tgcctccatc tgcccacggt ctaagaagat tcgaaagtga acacaaaact
    14641 aaaagacaag cacgtagaaa tcaaatttca atgtttcagt aaaacgttgg tttttggctt
    14701 tttgtcttac ataaaatatt aattattatg ttta
//
LOCUS       NM_001107142            3210 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus anaphase promoting complex subunit 7 (Anapc7),
            mRNA.
ACCESSION   NM_001107142 XM_001079480 XM_006249365 XM_222171
VERSION     NM_001107142.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Mansfeld,J., Collin,P., Collins,M.O., Choudhary,J.S. and Pines,J.
  TITLE     APC15 drives the turnover of MCC-CDC20 to make the spindle assembly
            checkpoint responsive to kinetochore attachment
  JOURNAL   Nat Cell Biol 13 (10), 1234-1243 (2011)
   PUBMED   21926987
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Song,M.S., Carracedo,A., Salmena,L., Song,S.J., Egia,A.,
            Malumbres,M. and Pandolfi,P.P.
  TITLE     Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a
            phosphatase-independent manner
  JOURNAL   Cell 144 (2), 187-199 (2011)
   PUBMED   21241890
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Jin,L., Williamson,A., Banerjee,S., Philipp,I. and Rape,M.
  TITLE     Mechanism of ubiquitin-chain formation by the human
            anaphase-promoting complex
  JOURNAL   Cell 133 (4), 653-665 (2008)
   PUBMED   18485873
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Dube,P., Herzog,F., Gieffers,C., Sander,B., Riedel,D., Muller,S.A.,
            Engel,A., Peters,J.M. and Stark,H.
  TITLE     Localization of the coactivator Cdh1 and the cullin subunit Apc2 in
            a cryo-electron microscopy model of vertebrate APC/C
  JOURNAL   Mol Cell 20 (6), 867-879 (2005)
   PUBMED   16364912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_006249365.4, NM_001107142.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.43281.1,
                                           SRR26643284.15757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000012.1  39820643-39820817   c
            176-362             JAXUCZ010000012.1  39816187-39816373   c
            363-482             JAXUCZ010000012.1  39815408-39815527   c
            483-594             JAXUCZ010000012.1  39807299-39807410   c
            595-748             JAXUCZ010000012.1  39806631-39806784   c
            749-891             JAXUCZ010000012.1  39804492-39804634   c
            892-1009            JAXUCZ010000012.1  39802068-39802185   c
            1010-1206           JAXUCZ010000012.1  39798488-39798684   c
            1207-1431           JAXUCZ010000012.1  39797686-39797910   c
            1432-1582           JAXUCZ010000012.1  39796765-39796915   c
            1583-3210           JAXUCZ010000012.1  39793514-39795141   c
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3210
                     /gene="Anapc7"
                     /note="anaphase promoting complex subunit 7"
                     /db_xref="GeneID:304490"
                     /db_xref="RGD:1311927"
     exon            1..175
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1772
                     /gene="Anapc7"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 7"
                     /protein_id="NP_001100612.1"
                     /db_xref="GeneID:304490"
                     /db_xref="RGD:1311927"
                     /translation="MSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQ
                     LLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEI
                     EVKYKMAECYTMLKLDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKE
                     VLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNS
                     RAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDV
                     YGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQL
                     NSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREA
                     MVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAE
                     LLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVSVNEYQEAMDQYSIALSLDPND
                     QKSLEGMQKMEKEGSPTDATQEDDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ"
     misc_feature    <369..1250
                     /gene="Anapc7"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     Region: PEP_TPR_lipo; TIGR02917"
                     /db_xref="CDD:274350"
     misc_feature    <369..1250
                     /gene="Anapc7"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     Region: PEP_TPR_lipo; TIGR02917"
                     /db_xref="CDD:274350"
     misc_feature    987..1664
                     /gene="Anapc7"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    987..1664
                     /gene="Anapc7"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; Region: LapB; COG2956"
                     /db_xref="CDD:442196"
     misc_feature    order(1011..1016,1020..1022,1092..1094,1101..1106,
                     1113..1118,1122..1127,1194..1196,1203..1208,1215..1220,
                     1227..1229)
                     /gene="Anapc7"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1011..1016,1020..1022,1092..1094,1101..1106,
                     1113..1118,1122..1127,1194..1196,1203..1208,1215..1220,
                     1227..1229)
                     /gene="Anapc7"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1086..1178
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1086..1178
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1398..1484
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1398..1484
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1497..1583
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1497..1583
                     /gene="Anapc7"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     exon            176..362
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            363..482
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            483..594
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            595..748
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            749..891
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1009
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1206
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1431
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1582
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..3210
                     /gene="Anapc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactttccct gagactcggc tccgctcctg ggggttctgt cagctgctgc tgggtcacgg
       61 tgtcgccggg caggatgagt gtgatagatc atgtgcggga catggcggcc gctgggctgc
      121 actccaacgt gcggctcctc agcagcttgc tgctgaccat gagtaataac aaccctgagc
      181 tgttttcccc gtctcagaag taccagcttc tggtgtatca tgcagattct ctctttcacg
      241 ataaggaata ccgcaatgct gtgagtaagt ataccatggc tttacagcag aagaaagcct
      301 taagtaaaac ttcaaaggtg cgaccttcaa ctggaaattc tgcatctact ccacagagcc
      361 agtgtcttcc atccgaaatt gaagtgaaat acaaaatggc tgagtgctac acaatgctga
      421 aactggacaa ggacgccatt gctatactcg atgggatccc ttcaagacaa agaaccccca
      481 aaataaacat gatgttggca aacctgtaca agaaggctgg tcaggaacgc ccgtcggtca
      541 ccagctataa ggaggtcctg cggcagtgcc ctttggccct tgacgccatt ctaggtttgt
      601 tatccctgtc tgtgaaaggt gcagaggtgg catcgatgac aatgaatgtg atccagactg
      661 tgcccaacct ggactggctg tccgtgtgga ttaaagcata cgcttttgtg catactggtg
      721 acaactcaag agcgatcaac accatctgtt cgctagagaa aaaatcctta ctgcgagaca
      781 atgtggacct gctggggagc ctggcagacc tgtacttcag agcaggagac aacaagaact
      841 cagtcctcaa gtttgagcag gcccagatgc tggaccctta cctgataaaa gggatggatg
      901 tttatggcta cctcttggca cgagaagggc ggctagagga tgtggagaac cttggctgcc
      961 gccttttcaa tatttctgat cagcatgccg agccttgggt ggtctccgga tgccacagct
     1021 tctacagtaa gcgctactcc cgggccctgt acttaggcgc caaggccatt caactgaaca
     1081 gcaacagtgt ccaagcttta ttactcaaag gagcggcgct tagaaacatg ggaagagtcc
     1141 aggaagctat aatacatttt cgggaggcca taaggcttgc gccttgtcgc ttagactgtt
     1201 acgaaggtct catagaatgt tacttagctt ctaacagcat ccgagaggcc atggtgatgg
     1261 ccaacaatgt ttacaaaact ctgggtgcaa acgctcagac gcttaccctg ttagccaccg
     1321 tgtgtctgga agatccagtg acacaggaga aagccaaaac cttgttagac aaagccctgg
     1381 cccagaggcc ggactacgtc aaggccgtgg tgaagaaggc agaattgctg agcagggagc
     1441 agaagtacga agatggaatt gctctgctga gaaatgcact ggccaaccag agcgactgcg
     1501 tcctgcaccg catcctgggg gacttcctgg tgtctgtgaa tgagtaccag gaagcaatgg
     1561 accagtatag catagcactg agtttggacc ccaatgacca gaagtccctg gagggcatgc
     1621 agaagatgga gaaggagggg agccccacag acgccactca ggaggacgac gtggacgaca
     1681 tggagggcag tggggaagaa ggggacctgg agggtagcga cagtgaggca gcccagtggg
     1741 ctgaccagga gcagtggttt ggcatgcagt gagggcacag cggtgaccct tgtgtcccta
     1801 gagtggcagg agctgttgga cgtgtgctca cagcaggcct ttctgcctgt ttcctcaagt
     1861 tggcactgat gtttgtccgt ctgctttgct gtggactgag cgagttccga gccacagact
     1921 cgccattctg gatggttcgg ctgcacgaaa tggaagatgc tttttctctt tatgagcggg
     1981 tacataggac tgagccatcc tcttaagagc acatgcccct gggtggccct gtcagaggtt
     2041 cggtccctgg gagtcacatc ctggtacggc cacactcctg tagtcatgga gctctggatg
     2101 ggggggggcg ggctgtgcct cactgactgc agagcaggct cggcctcagt gggcagatct
     2161 gagaagcaga tgatgggagc atggccaccc cagggcaggt tcaactaata aaactgccca
     2221 gtgtggtgtc acatgtcaca gtggacaccc tttgagactc ttcctttttc ctccttgtca
     2281 gaggcagcca tgcaggccta gacagtttga catacatata ctccctattc tcccatgtgc
     2341 tgggaggcag agccctgagc ttgtcacaca gaaccagcct ggctctttcc tgagtccctg
     2401 agggcagggt cagccttgat catctgccta gagtctcatt cagctactgg ggatgggtcg
     2461 actccaggtc cctcctgggt gcctttcaag atgcagatcg gtgtgctagg aagaaatgag
     2521 gtttactgta aagaatccgt agtcgatttc agagcatctg tcagtgcagt gaagtgggcc
     2581 acgtagtctg gtggaaacat tccggaagcc tgcacttggg aggcagaggc agacagttca
     2641 aatgtgctgg gctgcactgc aagatttgca ttaagagaca taagttaagc ggaccaggtc
     2701 tcataaagtg tgtcagtgag cctcagcctc cacactagcc ggccctgagc agtctcaggc
     2761 tccctttgag caagcagcat gtgggtggtg cttttcctga ctccaccccg ccagcagccc
     2821 cactcaccag tcagtgctga gagaaggcaa aatctgttca gccacaaatt gaacccagtc
     2881 taccccctgt cttcatgcca gacgggatcc ccacaggtca gggtggatgc ccagtgtctg
     2941 cagtgtgctg gaattcctcc ccttcttgtg tgtcacactc attgctacca ggagccagtg
     3001 tgacctctcc attccagcag cacccagctg gacccctcag gtccacctta gactgaggtg
     3061 gggagcacct ctcgggtgtg aaaatacttg gcccctcaaa ggatagtgtt ggcttttcca
     3121 tggtcacaac atcaggattg ggagccctgt ggctgtccac ttgaacatcg tgctcctaaa
     3181 ctagataaag tgaaggtgtc ctttaacttg
//
LOCUS       NM_013224                435 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus ribosomal protein S26 (Rps26), mRNA.
ACCESSION   NM_013224
VERSION     NM_013224.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   2  (bases 1 to 435)
  AUTHORS   O'Donohue,M.F., Choesmel,V., Faubladier,M., Fichant,G. and
            Gleizes,P.E.
  TITLE     Functional dichotomy of ribosomal proteins during the synthesis of
            mammalian 40S ribosomal subunits
  JOURNAL   J Cell Biol 190 (5), 853-866 (2010)
   PUBMED   20819938
REFERENCE   3  (bases 1 to 435)
  AUTHORS   Kuwano,Y., Nakanishi,O., Nabeshima,Y., Tanaka,T. and Ogata,K.
  TITLE     Molecular cloning and nucleotide sequence of DNA complementary to
            rat ribosomal protein S26 messenger RNA
  JOURNAL   J Biochem 97 (4), 983-992 (1985)
   PUBMED   2993263
REFERENCE   4  (bases 1 to 435)
  AUTHORS   Stahl,J. and Kobetz,N.D.
  TITLE     Affinity labelling of rat liver ribosomal protein S26 by
            heptauridylate containing a 5'-terminal alkylating group
  JOURNAL   Mol Biol Rep 9 (4), 219-222 (1984)
   PUBMED   6708946
REFERENCE   5  (bases 1 to 435)
  AUTHORS   Collatz,E., Ulbrich,N., Tsurugi,K., Lightfoot,H.N., MacKinlay,W.,
            Lin,A. and Wool,I.G.
  TITLE     Isolation of eukaryotic ribosomal proteins. Purification and
            characterization of the 40 S ribosomal subunit proteins Sa, Sc,
            S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18,
            S19, S20, S21, S26, S27', and S29
  JOURNAL   J Biol Chem 252 (24), 9071-9080 (1977)
   PUBMED   925037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X02414.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210888.1, X02414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..435
                     /gene="Rps26"
                     /note="ribosomal protein S26"
                     /db_xref="GeneID:27139"
                     /db_xref="RGD:621044"
     exon            1..26
                     /gene="Rps26"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..371
                     /gene="Rps26"
                     /note="40S ribosomal protein S26"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS26"
                     /protein_id="NP_037356.1"
                     /db_xref="GeneID:27139"
                     /db_xref="RGD:621044"
                     /translation="MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNI
                     VEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPRFR
                     PAGAAPRPPPKPM"
     misc_feature    24..326
                     /gene="Rps26"
                     /note="Ribosomal protein S26e; Region: Ribosomal_S26e;
                     pfam01283"
                     /db_xref="CDD:426179"
     misc_feature    24..326
                     /gene="Rps26"
                     /note="Ribosomal protein S26e; Region: Ribosomal_S26e;
                     pfam01283"
                     /db_xref="CDD:426179"
     misc_feature    183..185
                     /gene="Rps26"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P62854; propagated from
                     UniProtKB/Swiss-Prot (P62856.3); phosphorylation site"
     misc_feature    276..368
                     /gene="Rps26"
                     /note="propagated from UniProtKB/Swiss-Prot (P62856.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            27..204
                     /gene="Rps26"
                     /inference="alignment:Splign:2.1.0"
     exon            205..335
                     /gene="Rps26"
                     /inference="alignment:Splign:2.1.0"
     exon            336..435
                     /gene="Rps26"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      435
                     /gene="Rps26"
                     /note="polyA site"
ORIGIN      
        1 ctctttcgag tcttggctcc aatatgacca aaaaaaggag aaacaacggt cgtgccaaaa
       61 agggccgcgg ccatgtgcaa ccaattcgct gcacgaactg cgcccggtgc gtgcccaagg
      121 ataaggccat taagaagttt gtcattcgga acattgtaga agccgctgca gtcagggaca
      181 tatctgaagc aagcgtcttc gacgcttacg tgcttcccaa gctctatgtc aagctgcact
      241 actgcgtgag ctgtgccatt catagcaagg ttgtcaggaa tcgatctcgt gaggcccgga
      301 aggaccgaac acccccacca cgattcagac ctgctggcgc tgcaccacga cctccaccaa
      361 agcccatgta aagaggtgat ttcatgaaga cagaaagaaa aataccatgg aaaaataaaa
      421 ctgaagttat acttt
//
LOCUS       NM_001437679           13427 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus INO80 complex subunit D (Ino80d), transcript
            variant 1, mRNA.
ACCESSION   NM_001437679 XM_006245032
VERSION     NM_001437679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 13427)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_006245032.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2289702.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000009.1  72007345-72007484   c
            141-232             JAXUCZ010000009.1  71988716-71988807   c
            233-479             JAXUCZ010000009.1  71988364-71988610   c
            480-1210            JAXUCZ010000009.1  71980268-71980998   c
            1211-1319           JAXUCZ010000009.1  71974486-71974594   c
            1320-1544           JAXUCZ010000009.1  71969327-71969551   c
            1545-1654           JAXUCZ010000009.1  71963374-71963483   c
            1655-1788           JAXUCZ010000009.1  71960532-71960665   c
            1789-2006           JAXUCZ010000009.1  71955044-71955261   c
            2007-2164           JAXUCZ010000009.1  71954146-71954303   c
            2165-13427          JAXUCZ010000009.1  71940941-71952203   c
FEATURES             Location/Qualifiers
     source          1..13427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..13427
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="INO80 complex subunit D"
                     /db_xref="GeneID:316440"
                     /db_xref="RGD:1304808"
     exon            1..140
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            141..232
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            233..479
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    250..252
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="upstream in-frame stop codon"
     CDS             262..3327
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /codon_start=1
                     /product="INO80 complex subunit D"
                     /protein_id="NP_001424608.1"
                     /db_xref="GeneID:316440"
                     /db_xref="RGD:1304808"
                     /translation="MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDK
                     TAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPVDEVKV
                     RHQMDAMAFSLTVPTLALKMPNGLDSMSLSPPGARVPLHYLETELEDPFAFNEEDDDL
                     KKGVTVRKKLQSKLAQNRQRQRETEILKVRQEHFSTPPTPPQQHAHLSPLPTSLKPPA
                     PPQGSVCKSPQPQSTSLPMQGVAPTTHSIAQTRQASHKRPLPLLPSSRAPVSDTPRTD
                     RILMKATAFSPHFSCISRLQRLVKLCTQKHQLDADLFPHLGLDWSEESGEELEDSDQA
                     SPYQVAWSVRETLRQERHTSDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAESRQKK
                     CRHTFRKALLQAASKEPECTGQLIQELRRAACSRDSLSQTKLKEVEPAACSGTVKGEQ
                     CTNQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKK
                     MDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNL
                     SMPTSVSLPVQASQIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFADVLPRLP
                     DDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLSQSDGVPVQGLSD
                     RGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVHDSFSSLELDENLLHSATLSNPP
                     TPLAGQIQGQFSAPASVGLTSATLLSQSALGERAFPGQFHGLHDGSHASQRPHPAQLL
                     SKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTSYSGDNMAATFSA
                     EMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAFSNLLGADGHLLSTSLST
                     PPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAA
                     FGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASPPFPTPN"
     misc_feature    313..498
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    313..498
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    <769..>1116
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    <769..>1116
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK12323; cl46901"
                     /db_xref="CDD:481241"
     misc_feature    1585..1779
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     misc_feature    1585..1779
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /note="Potential DNA-binding domain; Region: zf-C3Hc3H;
                     pfam13891"
                     /db_xref="CDD:464023"
     exon            480..1210
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1319
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1544
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1654
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1788
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..2006
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2164
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..13427
                     /gene="Ino80d"
                     /gene_synonym="RGD1304808"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcatcctg cgctggcccc aggctctccc gcgggacgga aggccgggca gcggggaccg
       61 gggcggcggg gccttggagt agggactgta cggcagtacc ccgtccccgg gcatcgcgct
      121 gacggggccc ccggattccg acaatctgct tcttcttgat tgatcagcat tccaaactgt
      181 ggtacccctg ggctctcttc acattgctgt ggtgcagaag atttaaaatc agctgatgtt
      241 cacaaggaat agagtcacgt gatgtatgaa gggaaacata tacacttctc tgaggttgac
      301 aataagccct tgtgctcata tagccccaaa ctgtgcaagc agcggcgact caacggctac
      361 gctttctgta tcagacacgt tctggaagac aagactgccc ccttcaagca atgtgaatat
      421 gtggccaagt ataacagcca gcgctgcacc aaccccattc ccaagtcaga ggatcgcagg
      481 tactgcaaca gccacttgca ggtactcggc tttatcccga aaaaagagag gaagaaaaag
      541 aatgacccgg tagatgaggt gaaggtcagg caccagatgg acgccatggc atttagcctg
      601 acggtaccta ccctggcctt gaagatgccc aatggactgg atagcatgtc cctctctcca
      661 cctggggcaa gggttcctct ccactacctg gaaactgagt tggaagaccc ctttgctttc
      721 aatgaggaag acgatgacct aaagaaaggg gtgacggtga gaaaaaagtt gcagagcaaa
      781 ttggctcaga accggcaacg ccagagagag acagagattt taaaagttcg gcaagagcac
      841 tttagcaccc ctcccacacc tccacagcag cacgcccacc tgtcacctct acctacttct
      901 ttaaaacctc cagcgccacc acagggctca gtctgcaagt cacctcagcc tcagagcacc
      961 agcctaccaa tgcagggagt ggcccccacc acacactcta tagcacaaac aaggcaggcc
     1021 tctcacaaga ggcctctgcc cctccttccc tccagtcgag ctcccgtctc agacaccccc
     1081 aggactgacc gaatcctcat gaaagccacc gccttctctc cacacttctc ttgtataagc
     1141 cgactgcaga gactggtgaa actgtgtacc caaaagcatc agctggacgc ggatctgttt
     1201 cctcacttag ggctggactg gtctgaggag agcggagagg agctggagga ttcagatcag
     1261 gcttcaccat atcaggtcgc atggtccgtc cgagaaaccc tcagacagga aagacacacg
     1321 tcagatgacg acgatgcgga gagcaggagc tccagggtga cccaactttg cacttacttt
     1381 cagcagaaat acaagcacct ctgccgcctg gagcgtgcag agtcgcgaca aaagaaatgc
     1441 cggcatacgt ttaggaaggc gctgctgcag gcagccagta aggagcccga atgtactggt
     1501 cagctgatac aagaacttcg gagagctgcg tgtagccgag acagcctcag ccagaccaag
     1561 ttgaaggagg tggagccagc agcttgcagt ggaacagtga agggtgaaca gtgcacaaac
     1621 caggccctgc ccttcaccag gcattgtttc cagcacatcc tcttgaaccg ttctcagcag
     1681 ctgttctcca gctgcactgc caagtttgca gacggacagc agtgctctgt gccagtgttt
     1741 gacattacac accagacgcc cctgtgcgaa gaacatgcca aaaagatgga taatttcctg
     1801 agaggagata actcccgtaa agttcagcac cagcaacaga ggaaacctag gaaaaaaaca
     1861 aagccccctg cacttaccaa aaaacacaag aagaagagac ggcgtggacc tcgtcgaccc
     1921 cagaagccca tccctcctgc agtgccccaa gggaatctca gcatgcccac cagcgtctca
     1981 ctgccagtgc aggcctccca gatccgaagc ccttccacgc cagagctgag tgctgacgag
     2041 ttgccggatg acattgccaa tgagatcact gacattccgc acgacttgga attgaaccag
     2101 gaagactttg cagatgtcct gccgcggctg ccggatgatt tacaagactt tgattttttt
     2161 gaaggaaaga atggagacct cctcccgacc actgaagaag ctgaagagct tgagcgggcc
     2221 ttgcaagctg taacttctct cgagtgcctg agtacaattg gggtactttc ccagtcagac
     2281 ggtgtgccag tccagggctt gtcagataga gggatggggg tgttctccac gggtaccgat
     2341 gcttcgggaa tccagtcctt gagtcgagaa gtaaacacgg atctagggga gctactgaac
     2401 ggacgtatag tacacgatag cttttctagt ctagagctgg acgagaacct actccattct
     2461 gctactctgt ccaacccacc tacacccctg gcagggcaga tccaggggca gttctctgcc
     2521 ccagccagcg ttggccttac ttctgccact ctgctcagcc agagtgcact tggggagaga
     2581 gccttcccag gacagtttca tggacttcat gatggcagcc atgcctctca gaggccacat
     2641 cctgcccagc tgctgagcaa ggcagacgac cttatcacct cacgacagca atacagcagt
     2701 gatcattcac actcctcacc ccatggaagc cattatgata gcgagcacgt gccgtcgccc
     2761 tacagtgacc atatcacctc tccccacaca tcttactctg gtgataatat ggcagctacc
     2821 ttttcagcag agatgcccat catggcccag cacttgctcc ccacccagct tgaggtgcca
     2881 cttggaggag tggtcaaccc cagaactcac tggggcaatc tccccgtcaa ccttggcgat
     2941 ccctctgcat ttagcaacct ccttggcgcg gatggacacc ttctttccac ttccctctcc
     3001 acgccaccca ccacatccaa ctcagagacc acacagcctg ccttcgccac cgttacccca
     3061 agcagttcca gtgtgcttcc ggggttacca cagaccagct tcagtggcat ggggccttct
     3121 gctgaactaa tggcctccac ctctcccaag cagcaactcc cacagttcag cgcagccttc
     3181 ggccaccagc tgagttctca cagtggcatt cctaaggacc tgcagcccag ccacagctcc
     3241 atagcccctc ctacaggctt cacagtaaca ggtgccaccg ctacaagtac caataatgca
     3301 tctcccccct tccccacccc caactgagcg agtctgtgtg cttgccggca ggtggaaccc
     3361 ggtgttttct atctttgttt cctcttttgc acccctctct ccttttccta cagaagattt
     3421 aaaaatgaca gtggggatta gagggacgcc ccttcccggt tcaacaggtg gccgtgcagt
     3481 ggaccttgcg tcagtgttcg cgcgtgctcc ctagcactgg tgctcattcc ctcctggcgg
     3541 tccgctcagc ctggcgggtc actcggcctg gcaggctttt tggtggctca gcacagtgac
     3601 tgggtaggat tgattatttt attttttatt tttattttta tttgttttta tttcagcaag
     3661 tcctagaagt ggaagatacc tcagattacc agtgcccttt actgtctcct actgttgaga
     3721 taatgcttcc cattctctag ccaggtttta cataggttgt tctggatgtt ctgttgagat
     3781 cctgtgtagt aggtggtgtg cggacacaaa tcaaagctct gacttagcac caactgccag
     3841 acaccacagg gaggccagga tgccattcct aattatgata cattagctga aaagaacatg
     3901 gtctcttaac tgcctgtgcc tgcttgttca ttcgtcctgt gtgtgtgctg tgcagtgcag
     3961 tagctgtcgc ttgtggcttg tctctcctca ctcccagaat aagcataggc ccttccccct
     4021 cctcctgtct catgccttgc aagattcgtc cttccttcct actgagttgc taaagcatcc
     4081 tgaacagaga ggggtggtct cagagtgata gcgccttgct aaaatcagcc tgtgaggaaa
     4141 ggagcccaga ggcggagctc acatcagtca tggggagtgt cgtgaccccc cacctctctt
     4201 ctatcatgtg catttgtttc agattcccca ctcatggaac acatttgtaa gtagtaatga
     4261 aaaaaatgtt ttggtgtgca aaagcaggct acaccagaga gattcgaaag atgacatctc
     4321 ggcctgtttg gtccatcatt ggctcctagt ttttacatgt ttacagttgt gattctttgg
     4381 tgagatttgt gaactgtgga ggacacctgt agaaccgtgt accagttgtg aagtgatgtg
     4441 taatatcaga aggacacaca ttttaacagt tctgtcaaag cagaatttgg aaattagaca
     4501 taatttgact caccttaggt acttttaaaa taatttaagt aaaattggaa aattttttta
     4561 acgtaccaag gctttagggt aaaaaatctt gttgggtagt gcagtaagtt ggtgactgtg
     4621 aagtgatgtg agggtttcct cttgcctgcc ttcccctccc agcggggtgg agcttcattt
     4681 tctgctctgc tctgctctgc tgatggctcc ctgccccttc agatatcgtc aggtgtctac
     4741 atctgagctc cacctgattt acatgcagac actcttaaaa gtgaggcagc atgtctctaa
     4801 atgacgtgtg tggtacagca atcctttagt cagggactgt ctgatcctaa ttccttcctg
     4861 cgagtttaag gttgggacgt attttcctac ttcttatgtg tgtgttcctc gtgctacttc
     4921 tgaccaggtc ttcctgttga aggccttgca aaggaatgat ggtggttacc aggcattatg
     4981 cagacaccac gtgcctgagc tttggagaga aagtgtcaca tgaccagatg aaatcatgat
     5041 ctgacctatt ttgtatttac tgaagttggg gaggcaaata tgtttgtaat atgtttcctt
     5101 tttttcctta aaaataatgt tagttaattg gaacatttgt ttttaatagc tttgcctttt
     5161 tttgcaaatt gagaaaatcc taaattataa attatgtcac aaagcaaaat tatatttggt
     5221 atcaccatga acttctctcc tgaattgtga gaacagcttt ttgactgttt gatctgtgag
     5281 cctatgtcag tagctttttt attttagtat gctgtaatag agtgagagtg agtggttacc
     5341 tcacctcaaa agtgtcattt cgtttgttag gctgttctca catccccact agaatcattt
     5401 taggtaactg aattcccaga aaatgcattt tgtctccagt gtgcatcgac tgaagactgt
     5461 agcagagcca catggccgtc tccttatcgg ctcctctttg ccagggagag ggaagtcgtg
     5521 agtagtcaat ttggactgcc actgtctgtc tgtctctgtg ttagctgctg aaactcgttt
     5581 agttgtcaaa ctgagtttgc aggaggttgc accttttatt gtttgcagtt ttctgtttat
     5641 gtgcatttaa aagcccttct tcgctttcga gtaaggaggc ttgaagtgat caggaatgtt
     5701 gccagttaca gcttcacgcc aaaaatgttg agcaagctcc cttctgttca gatgcccatg
     5761 atggttgctg aagggagggc agtcttggaa atactgataa tggactgaat aattagcaaa
     5821 agcacacttt ccttccgtct cagaacgaac atccaagcct gtaatttgct tttctcttgg
     5881 tttttttgtg agctccctgt tagaggaata tctgtttcta agcccagagg tgtccacttt
     5941 gtcacccctc tagctgttga agcaattcta gtctcttagt agtaggtggg tattaatatg
     6001 caaagaaagt tcagcatctt ttgtaatgct tatatgaaaa cgtagcactt atggtaaggc
     6061 aatactggaa tcaaaaacaa accctgcaca ggccctaatg ggatagaagc tagtattagt
     6121 gtagtgttga gtacatgagg gacagtaaca aagaaggctc actgtgtctc tgcgggttct
     6181 gggaccattt ataaaggcca gttcattgtg ttactgtgac ttaacttgtg aagttgctgc
     6241 cgttgatgac tgactatgtg ctctgagaat atgaatgtca gcaactgtaa tctctggtac
     6301 ctgaagggaa gatgggcttt ctctccttta actgctaatg ttattttagt gaaagtactc
     6361 aagacattgt ttttttcttc tgtaaaaatg gcttagcaat gttcatacct gggtaggtta
     6421 tacagctagt gaacaattca ggatagtaaa tgacagttag aggaagccca ccaagtaaca
     6481 gactctgcaa tggacacatc ttgtacttat catcccatag ttgaaagcag agattttctc
     6541 tagtgagcct actgtgtgag gtattcctgc ttataaatga cagcagttcc ctgttggcag
     6601 gtaatgtgat ctaatgtccc tctgtgagaa gattttggtt tgatgagaag cagatagtta
     6661 ttagagatgg agttggaaag tgattatttt atattgccaa ataactgttt ataagatgaa
     6721 tcttttaaag taaaaccaga ctgtcacctg aaggttaggg aatcatccct tctgagagtc
     6781 acactaaaaa ctcttccaaa gttcattctc agtccatcca tgctcccggt ccacatggca
     6841 aagtcagttc tgtgtttagg agggagccat gttcaggcat cctgaatatt tagtttcttt
     6901 tacacgaaag aatagctttc tgttggcttc ttgcattgct tgttataaat aaggcattag
     6961 agatgagtca ctcacacaga ggtgaacccc ttactgtgtg ttccttgacc ctgccccgct
     7021 gtgcgctgtg cgctggcatc ctggtcagcg gcgggtggcg tgtgggcgtc ctcttcagtg
     7081 cctgtctgaa agcattgcct tctctagtgc agttctcagc atggctgtgc gttgtttcac
     7141 actgcagagt gggagtgagg atattaacac tcaactcctt aataggtttg gaattcatta
     7201 tacttttaaa agtatttact ttttagtctc ctttttagac ttaaaaagat taagttctat
     7261 actttatctg acatgtgtag gataatctaa taaatggttt gttgaatggt caacacaact
     7321 ctgcagtata atgaggagat ttagaaacat ctttgaaaga taatttaatt ggagtgagtg
     7381 ttctctcgta tttttttttc tttactgcta cccacattgt tctatggatt cttcatgtca
     7441 agagtacttc atgggagaca gtcattcatg aaaagacata tttttccccc tttcaacaaa
     7501 taaaaaaata actgacttct tccctgaaat tcagaaaaaa gaaaaatgac ttcttaatac
     7561 tttggcttct ttagccttcc catgttatta tatttgtggg acccaaaatc acagtttaat
     7621 taaagtagta tttacatgag atctttcaaa atgtttataa tacaatgcgg tctctgagaa
     7681 aagcagaggc agatgcctgt tgagcctttc cactggccag tgagtgagtg agtcaggaag
     7741 gcctgtgtgg gattagccct gcctctcgta aggcccagtg tgtggatgcg tggttgtgag
     7801 taactgtagg aacctgtggt tctttactcc agtgtttgtg cttggctggc ttcccctctt
     7861 gcactgtggt gtgaagcaag tagaagagat gtggcatttc agagatttgt tgtgacttta
     7921 tttaccctgt gtttctgagt atcaggaatg ttttgagtgc tttgaagagc agatcaacat
     7981 ggtctttggc tgacctaaag ctagtctaga aagcagtctt ctgaggtgaa agctgctcga
     8041 ctcttgatgg ctggcgggca gcatgttttc ttctcttcct ccctccctct gccttttgca
     8101 cgctcttccc cgtgctgcag tgtgcgtgtg ccgcactcgt cttggcccaa gagtggtagg
     8161 attttcattc gttggttctc attgttctta tgtgtttgtt tgtttgcttt ttaagctggg
     8221 gaccactgac ctaagctcta tatgcacccc aagttcccca tggagaacgc ttcaacatgc
     8281 aggacggaag gcaccagtta cagctcaagg ccacaccgtc gcttttcctt ggggacttag
     8341 gctgatttgc ttggaactga ccccagcctg tgtcatgtag tccaggcggc tccagcgggt
     8401 tagtgctgac tcgggggaga gcttgacacc tgccgacagt gtgtgcctct gctccaaagg
     8461 gttgaatcag ttcttctcaa cggtgatagc tcttctcact gtctagtgtt gagtatgtct
     8521 cagggattcc ttgcggaaat tagggcagtt tttaaaataa ggaaatagtt ttaaaggaaa
     8581 ctaaaggtga ctcctcactg atgagagctc cagaaagaga aagcgtttgg tttcacagcc
     8641 cgtggtgtct cgccgaggac ttcctttcta cttcaggctc tcatctcagc ttcagcttac
     8701 agaatccttt cccatcatgc acagctttaa aacttttatt taaaacttcc ttccccaatg
     8761 agctttcaga atacttattg tagattttaa gagaaaaggt atattaattt atgctattaa
     8821 catcacctca taaattataa gttttatact aaagctgtat tgagtgtaat gaattatgtt
     8881 gcctatgtgt tttaatagct taaaattata tatgagcttc tttttatttt tatttttatt
     8941 ttttgacaaa acaaactagt gacgcacctt cttacactgg atctctgccg tgtcaaggtg
     9001 taacgctgtc cttgctacct tgcagataca taaagaaaag gatagcctgg ggcctcgaaa
     9061 tggagaccac cctagaccac ttactattgt gtatagagct gttgagggtc atgttctctg
     9121 cacatgatct gtggtttaca cttaagatgg ctagacactt agttacaggg taagtagaag
     9181 caaatagatc aagtaaaacg cccactactg tagctggaat ttgtaaactt aagtttttaa
     9241 gacctcttat ttcctatgga tttattcttt aatttacagt ttattctgta agttgagaag
     9301 taaaatagag aaattaataa atctagatgt tctcagtgtc tcattcagga acgttttacc
     9361 cctcctcact aaggaattcc cactgtgact taaaaataga ggtaaattac ttgtgtgcat
     9421 gtatgtgtct gtgtttttac acaaatgcaa aaatatacat cgggggcacg tgtgtgagat
     9481 atgaatgtgt gcttgtgtaa aaatagaaag gtaaccgaat gtattataga aatatgattt
     9541 atttagctga gggtattaga gttattttcc cattgtttct attttataaa catgccatat
     9601 tcttggctat attctgttca aaggctagct ctgatatcac gcgcattttc tattaactta
     9661 ggctgttttt aaaagtgaca cgagaaaaga agcagattct aagaccagcc ttttagttat
     9721 gagcataacg acgagagagc gagagcgaga gcgagagaga gagagagaga gaaagagaga
     9781 gagagaaaca gacctagata ggtaacagct catatatctt ttgaagtgat gggaccagag
     9841 atttgttgaa atattatgtc tagtaaattt tcttcatatt ccaagtaata aactaatatg
     9901 ttttcttggt caagttcaga aaacataggc cttgataagg aagctttgaa ggggctgctt
     9961 gttgaaggag ttggtgggct catctcccca tatatacttc aaagctggta tgatttcagt
    10021 tgtttgcaaa atattttttg aaacgaaatt gtgccattgg ttgtggagta gagcatccca
    10081 gctctgtcct ctggctgtgg gaaaatcatg cttacctgac tatgtggaac taaaaagaca
    10141 gacacattcc tgtgtcctgg gagctttgtc attctctgtg tggtccttcc tggaacacct
    10201 ggtgatctga gacggtcaac aagggccaag tgctccatca cacttacttt aatatgaagg
    10261 cgctgtactt agaaatgcca gggcaactcc caggaacaca cttgaattgg tagttgtctt
    10321 tggggcctca gttacttcat cttagatcca gacaaaaccc aggcaagctc tccatgttgt
    10381 ttttcacact tgtgtttttg tagcatctcc ctgtttcatt cactcttgct ttcagatttt
    10441 aagaaacctg catatttctt gtacatatgc atgcaagcga aagaagggag tttgtactga
    10501 tgccatttct cccttcagtt gctggttaat ggaatttgct agaatcaatt cccccttatt
    10561 gaagggtgaa aacagaccct ttgtgtatat ctgtacagag atgtgtatat gggatgtggt
    10621 ggcactttgc tgaatgtgaa cttgccttgt caatggaaag attgaaaaag tattatgttt
    10681 atttatacat ttgtataaat ctatatatac acgtatgtat atgtgtgtgt atagataaag
    10741 ctatatacat atatttccct aaaatgtgtg tgtgtaatag attaacagcc cttgctaagc
    10801 aagattatgc atctgtggga attctgggtt attctgccag ccagtggaaa tggccacagt
    10861 gtagagcaca tcaccaagca tgctgacgtg ggaacccttt ggattacagt cacgattaca
    10921 gattagtgct cacaaaccaa tctttgaact cttctttctc agatttctgc tagctattct
    10981 ctcattactt aacaatcaca catctttgcc aagttgtctg ttgtccaagt gctggagatt
    11041 ggctcctgag gtggccctgt gctgggcatg tgagaagcca cgtccttggg atgatttagc
    11101 tctctcacta gacacctggg catgaatgtg tcagctgtca ctcaggcctt accaacgaca
    11161 cttccccacg gtatacagct ttcaattatg ttttctctga gaattgggta gtcatcaaaa
    11221 ataaaaagcc aatgttcaaa aacttaattc tcaatttctt aacctaggta actttggagt
    11281 attttattta cattgaaaaa tgtaattatg actttatgat tgatattagt gttaggtgta
    11341 tttccacact tatcatttaa agagtttgat ttgctttgtg ttttaaatat aaccatttac
    11401 cacttgaatt ttaacaaagt acacagagtc acatggaagc ctcttgaatt ctataactga
    11461 ctcttgtttc tcatgatgaa atgctctaat gagttcttgt gtaataattc tgctagattt
    11521 ccttttgact tctctcacag ttgtgacatt cagttttaac tctgctgcag ctctctagaa
    11581 aacttgcacc cttctatatc gtgcctttaa agctcttatg cacacacaga agtgtatata
    11641 tacatgttgg cgcatgtgta catacacttt ggtatatact cacacagtat gtctccagga
    11701 tatattgtgg gagtggacat agagatattc aaaggcaatg aaatgttgct ctctagatat
    11761 atatgtatat aaatagtgtt gatataactg tacatacacg tgtatatgta tgagttctaa
    11821 atggcaatct tttacattta gcaaaatgct gccctactgg aatattgcca ctgcaatggc
    11881 acttgtatgt aatgatttaa aagacattat caaaaattat ttaaagaaca ttaaaggtct
    11941 catctaaaga cagccacaca ctatttattt agcttcctat tcctgtgatt gttgtgtttg
    12001 tataactgta agggagactg tcattttaaa ctcaccacct gtgtaggaga gatgagattc
    12061 actcggggta ctttgtatcc cctctctctg aaacagtgat gtgtcacagt ccagcttgtt
    12121 tatctcagtt ttaaagcagt cctagtactg ccattggtgt gtgtcaccca ccatgtcctc
    12181 gatcaactta cttcaccaat ttgcctcttc ctttcattaa taaataatga tcatttcgat
    12241 cagtttgcct gggggaaagc taactcctct cttgcttcag ggaaatagat catctagctg
    12301 ttgttctgcc ttgttcaaaa ttcaccatag aaagagggtg gtcctcataa cgctgtctta
    12361 agcatagttt atttttcatt tatttaaaga tcttactttt tttttttttt gaaagtactc
    12421 ttaagttgca tgtccttggc atagatttca ttcttactgc ccttccccac aggatatttt
    12481 tcatagtcca tcagtttccc ataccaaatg caagaacgtc aggacaaact gtcaatactg
    12541 ttgctgttcg cgaggggctg gcagcagatc acacctggaa tttagaggga gagaaggtag
    12601 ccggataatc ctgagccctg tgaagtggag cgtggaataa gggtacttct aaggaaacat
    12661 ttcagggtag ctcactggaa attgatatca gaatcagcct ttaacagcct ggcagaggga
    12721 tggtactaac tacccagcgt gcccaagtgt aaacaaacca agctgcagtg ggaagtcaaa
    12781 ggtgggaggt agccattgga aaccaggaac aaagtaactg cacggtagca aggactagca
    12841 gtctgttctc atccaccttg gcacaccgaa tgctccatac gccatacatt caggacatag
    12901 gcaggaggac agctgcttaa aggggactta caaaccaagc accttctctt gtgtctgtgt
    12961 catggctgcc actcagttcc aggcatgtac accgggagca actagtttct gcagaataca
    13021 agaggaggct ggcaggcttt ggaaaggcct ttccatggcg ttgcctgtga tttcagtggg
    13081 gaggacacat ttggggagat ggctgggctt ttggtttgtg atttcccttt aaacaggaag
    13141 agatggttca cactttccat atatatatct caatgaatgt actgtattac tgttttaaaa
    13201 atttgatgaa ataataatgg attggtctcc ttttgttatc tggtccttgt ttaatttgtt
    13261 taagggtttt tgtatacaaa agtttacatt tttatgtata tttttcttgt gtaaaaactg
    13321 atgtaatatg tgtataaaac acttgtatgt attatctgta tatagtgtga caaaatgatt
    13381 tttctttctt tcttttggtt gtattaataa atcttgctgt gaagtaa
//
LOCUS       NM_001109557             684 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus crystallin, gamma F (Crygf), mRNA.
ACCESSION   NM_001109557 NM_001085380 XM_001072649
VERSION     NM_001109557.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 684)
  AUTHORS   Kim,I., Saito,T., Fujii,N., Kanamoto,T., Chatake,T. and Fujii,N.
  TITLE     Site specific oxidation of amino acid residues in rat lens
            gamma-crystallin induced by low-dose gamma-irradiation
  JOURNAL   Biochem Biophys Res Commun 466 (4), 622-628 (2015)
   PUBMED   26385181
  REMARK    GeneRIF: Specific oxidation sites of methionine, cysteine and
            tryptophan in water-soluble and -insoluble gammaE and
            gammaF-crystallin were determined by one-shot analysis after
            low-dose gamma-irradiation.
REFERENCE   2  (bases 1 to 684)
  AUTHORS   Lengler,J., Krausz,E., Tomarev,S., Prescott,A., Quinlan,R.A. and
            Graw,J.
  TITLE     Antagonistic action of Six3 and Prox1 at the gamma-crystallin
            promoter
  JOURNAL   Nucleic Acids Res 29 (2), 515-526 (2001)
   PUBMED   11139622
REFERENCE   3  (bases 1 to 684)
  AUTHORS   Voorter,C.E., De Haard-Hoekman,W.A., Hermans,M.M., Bloemendal,H.
            and De Jong,W.W.
  TITLE     Differential synthesis of crystallins in the developing rat eye
            lens
  JOURNAL   Exp Eye Res 50 (4), 429-437 (1990)
   PUBMED   2338125
REFERENCE   4  (bases 1 to 684)
  AUTHORS   den Dunnen,J.T., van Neck,J.W., Cremers,F.P., Lubsen,N.H. and
            Schoenmakers,J.G.
  TITLE     Nucleotide sequence of the rat gamma-crystallin gene region and
            comparison with an orthologous human region
  JOURNAL   Gene 78 (2), 201-213 (1989)
   PUBMED   2777080
REFERENCE   5  (bases 1 to 684)
  AUTHORS   den Dunnen,J.T., Moormann,R.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Concerted and divergent evolution within the rat gamma-crystallin
            gene family
  JOURNAL   J Mol Biol 189 (1), 37-46 (1986)
   PUBMED   3783678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474044.2.
            
            On or before May 29, 2008 this sequence version replaced
            NM_001085380.1, XM_001072649.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF553419.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..684
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="crystallin, gamma F"
                     /db_xref="GeneID:689947"
                     /db_xref="RGD:1586353"
     exon            1..104
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..620
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="crystallin, gamma polypeptide 6;
                     gamma-F-crystallin; gamma-crystallin 4-1"
                     /codon_start=1
                     /product="gamma-crystallin F"
                     /protein_id="NP_001103027.1"
                     /db_xref="GeneID:689947"
                     /db_xref="RGD:1586353"
                     /translation="MGKITFYEDRGFQGRHYECSTDHSNLQPYFSRCNSVRVDSGCWM
                     LYEQPNFTGCQYFLRRGEYPDYQQWMGFSDSVRSCHLIPHSSSHRIRIYEREDYRGQM
                     VEITDDCPHLQDRFHFSDFHSFHVIEGYWVLYEMPNYRGRQYLLRPREYRRYHDWGAM
                     NARVGSLRRIMDYY"
     misc_feature    102..341
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="Beta/gamma crystallins; Region: XTALbg; smart00247"
                     /db_xref="CDD:214583"
     misc_feature    102..341
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="Beta/gamma crystallins; Region: XTALbg; smart00247"
                     /db_xref="CDD:214583"
     misc_feature    345..356
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="propagated from UniProtKB/Swiss-Prot (P10068.2);
                     Region: Connecting peptide"
     misc_feature    360..605
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     misc_feature    360..605
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /note="Beta/Gamma crystallin; Region: Crystall; pfam00030"
                     /db_xref="CDD:459639"
     exon            105..347
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /inference="alignment:Splign:2.1.0"
     exon            348..684
                     /gene="Crygf"
                     /gene_synonym="Cryg6; Len"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctgcca acgcagcaga cctcctgcta tatatataga ccctgctccc agccctacac
       61 aaccaacagc accatcccat ccgcaaacac cagccatggg aaagatcacc ttctatgagg
      121 accgaggctt ccagggccgc cactatgagt gcagcacaga ccactccaac ctgcagccct
      181 acttcagccg ctgcaactct gtgcgcgtgg acagtggctg ctggatgctc tatgagcagc
      241 ccaacttcac aggctgccag tatttccttc gtcgcgggga gtaccctgac taccagcagt
      301 ggatgggttt cagcgactct gtccgctcct gccacctcat cccccactcc agctctcaca
      361 gaatcaggat ctacgagcga gaggactaca gaggccagat ggtggagatc acagacgact
      421 gcccccacct gcaggaccgc ttccacttca gtgacttcca ctccttccac gtgatagagg
      481 gctactgggt cctctacgag atgcccaact accgggggcg gcagtacctg ctgaggccca
      541 gggaatacag gcgctaccac gactggggcg ccatgaatgc cagggtgggc tctctgagga
      601 gaatcatgga ttactattga attgtcttac tctgcccttt catcatttgg aagttaataa
      661 aatatttcct gtgtgttcca tgca
//
LOCUS       NM_001108335            3245 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus RAS protein activator like 1 (Rasal1), transcript
            variant 1, mRNA.
ACCESSION   NM_001108335 XM_001076575 XM_006249395 XM_341088
VERSION     NM_001108335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Hong,Y., Han,Y.Q., Wang,Y.Z., Gao,J.R., Li,Y.X., Liu,Q. and
            Xia,L.Z.
  TITLE     Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by
            regulating the expression of RASAL1/ERK1/2 signal pathway
  JOURNAL   J Ethnopharmacol 192, 114-122 (2016)
   PUBMED   27396351
  REMARK    GeneRIF: Paridis rhizoma sapoinins attenuate CCl4-induced liver
            fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
REFERENCE   2  (bases 1 to 3245)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (bases 1 to 3245)
  AUTHORS   Tao,H., Huang,C., Yang,J.J., Ma,T.T., Bian,E.B., Zhang,L., Lv,X.W.,
            Jin,Y. and Li,J.
  TITLE     MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in
            rats
  JOURNAL   Toxicology 290 (2-3), 327-333 (2011)
   PUBMED   22056649
  REMARK    GeneRIF: hypermethylation of RASAL1 is associated with the
            perpetuation of fibroblast activation and fibrogenesis in the liver
REFERENCE   4  (bases 1 to 3245)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_006249395.5, NM_001108335.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.45615.1,
                                           SRR26643292.48181.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000012.1  41573595-41573908   c
            315-371             JAXUCZ010000012.1  41570255-41570311   c
            372-485             JAXUCZ010000012.1  41568170-41568283   c
            486-547             JAXUCZ010000012.1  41567956-41568017   c
            548-677             JAXUCZ010000012.1  41562570-41562699   c
            678-759             JAXUCZ010000012.1  41559631-41559712   c
            760-891             JAXUCZ010000012.1  41559413-41559544   c
            892-977             JAXUCZ010000012.1  41558705-41558790   c
            978-1095            JAXUCZ010000012.1  41557983-41558100   c
            1096-1249           JAXUCZ010000012.1  41557705-41557858   c
            1250-1314           JAXUCZ010000012.1  41557299-41557363   c
            1315-1427           JAXUCZ010000012.1  41556938-41557050   c
            1428-1620           JAXUCZ010000012.1  41555495-41555687   c
            1621-1758           JAXUCZ010000012.1  41551508-41551645   c
            1759-1903           JAXUCZ010000012.1  41550265-41550409   c
            1904-2076           JAXUCZ010000012.1  41547288-41547460   c
            2077-2214           JAXUCZ010000012.1  41546254-41546391   c
            2215-2350           JAXUCZ010000012.1  41546041-41546176   c
            2351-2471           JAXUCZ010000012.1  41544782-41544902   c
            2472-2548           JAXUCZ010000012.1  41542798-41542874   c
            2549-3245           JAXUCZ010000012.1  41541864-41542560   c
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3245
                     /gene="Rasal1"
                     /note="RAS protein activator like 1"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
     exon            1..314
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Rasal1"
                     /note="upstream in-frame stop codon"
     CDS             250..2655
                     /gene="Rasal1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rasGAP-activating-like protein 1; RAS protein activator
                     like 1 (GAP1 like)"
                     /codon_start=1
                     /product="rasGAP-activating-like protein 1 isoform 1"
                     /protein_id="NP_001101805.1"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
                     /translation="MAKSGSLSIRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTAT
                     IWRSLSPFWGEEYTVHLPLDFHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGID
                     SWINLSRVDPDEEVQGEVCLAVKLLEDARGRCLRCHVRQARDLAPRDISGTSDPFARV
                     FWGSRSLETSTIKKTRFPHWDEVLELREAPGTTSPLRVELWDWDMVGKNDFLGMVEFT
                     PQTLQQKPPNGWFRLLPFPRAEDSGGSLGALRLKVRLTEDRVLPSQYYQPLMELLLES
                     VQGPAEEDTTSPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTN
                     DPNTLFRSNSLASKSMEQFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPSKMDLNRS
                     RRISFKGTPTEEQVRETSLGLLTGYLGSVVDAIVSSAGRCPLALRLAFKQLQQCVEKR
                     FPGMEHQDVKYLATSGFLFLRFFAPAILTPKLFDLRDHHADPQTSRSLLLLAKAVQSI
                     GNLGQQLGQGKEQWLAPLHPFLLQSISRVRDFLDQLVDVDGDEEAGGSTCALVQPSTI
                     VREGFLLKRKEEPASLATRFAFKKRYFRLSGRDLSYSKTPEWQVHSSIPLSCIRAVER
                     VDEGAFQLPHVMQVVTQDGTGASHTTYLQCKNVNDLNQWLSALRKASAPNPGKLAACH
                     PGAFRSGRWTCCLQAERSAVGCSRTHSAVTLGDWSDPLDPDAEAQMVYRQLLLGRDQL
                     RLKLLEDSSLDTAPDVDPGKDSSAVDGPCAEVLAQQREATTRLLQVLEDLEQAHEEFQ
                     KRG"
     misc_feature    265..627
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    265..627
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    649..1011
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    649..1011
                     /gene="Rasal1"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:472691"
     misc_feature    1033..1893
                     /gene="Rasal1"
                     /note="Ras-GTPase Activating Domain of RASAL1 and similar
                     proteins; Region: RasGAP_RASAL; cd05135"
                     /db_xref="CDD:213337"
     misc_feature    1033..1893
                     /gene="Rasal1"
                     /note="Ras-GTPase Activating Domain of RASAL1 and similar
                     proteins; Region: RasGAP_RASAL; cd05135"
                     /db_xref="CDD:213337"
     misc_feature    order(1150..1152,1258..1260,1264..1266,1270..1275,
                     1279..1281,1288..1290,1300..1302,1633..1635,1657..1662,
                     1669..1674,1681..1683,1744..1746,1753..1758,1765..1767,
                     1777..1779,1783..1785,1804..1809)
                     /gene="Rasal1"
                     /note="putative RAS interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213337"
     misc_feature    order(1150..1152,1258..1260,1264..1266,1270..1275,
                     1279..1281,1288..1290,1300..1302,1633..1635,1657..1662,
                     1669..1674,1681..1683,1744..1746,1753..1758,1765..1767,
                     1777..1779,1783..1785,1804..1809)
                     /gene="Rasal1"
                     /note="putative RAS interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213337"
     misc_feature    1903..2316
                     /gene="Rasal1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    1903..2316
                     /gene="Rasal1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    2290..2376
                     /gene="Rasal1"
                     /note="BTK motif; Region: BTK; pfam00779"
                     /db_xref="CDD:459937"
     misc_feature    2290..2376
                     /gene="Rasal1"
                     /note="BTK motif; Region: BTK; pfam00779"
                     /db_xref="CDD:459937"
     exon            315..371
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..485
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..547
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..677
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..759
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..891
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..977
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1095
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1249
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1314
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1427
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1620
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1758
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1903
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2076
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2214
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2350
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2471
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2548
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..3245
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgccagg ctcagcctgc ccagatcgca gcgcacagct acctgtagct ctggacgcat
       61 gtccccttcc gggacccagc acttctccct cctagccctg catccagccc actcgcaccc
      121 cagacccgta cctgtgggaa cccgtggact gcgtgcttgg cccgccgctg atgacatgta
      181 gggtcacctc ctggtccagc ctcggaacct cggcagactc cttgcctgga aagtttggga
      241 ctgtgcgcca tggccaagag cggctctctg agtatccgcg tggtggaggg acgggcgctg
      301 cccgccaagg acgtgtctgg gagcagtgac ccctactgtc ttgtgaaagt ggatgatgag
      361 gtggtggcca ggacagcaac catctggagg agcctgagcc ccttttgggg ggaggagtac
      421 actgttcacc ttccactgga cttccaccac ctggccttct acgtgctgga tgaggatact
      481 gttggacacg acgacatcat tgggaagatc tccttgagca aagaggcgat cacagcggac
      541 cctcgaggga ttgacagctg gatcaacctg agccgagtgg atccagatga ggaagtgcag
      601 ggtgaggtct gcctggctgt gaagctgctg gaggatgctc gggggagatg cctccgctgc
      661 cacgtgagac aggccaggga cctggcccct cgggacatct ctggcacatc ggacccattt
      721 gcccgtgtgt tctggggcag ccgtagtttg gaaacttcga ccatcaagaa gacccgattc
      781 ccacattggg atgaggtgct ggaactacga gaggctccgg gaaccacatc cccgctgcga
      841 gtggaactct gggattggga catggtgggc aaaaatgact tcctgggcat ggtggaattc
      901 accccacaga ccctccagca gaagccaccc aatggctggt tccgtctcct gccttttcct
      961 agagctgagg attctggggg gagcctgggt gccctgcggc tgaaggtgcg cctcactgag
     1021 gaccgggtcc tgccttccca gtactaccag cctctcatgg aactgcttct ggagtccgtg
     1081 caagggccag ccgaggagga caccaccagc cccctggcat tgctagagga gttggcctct
     1141 ggggactgtc gtcaggacct tgccaccaaa ctggtgaagc ttttcctggg ccggggcctg
     1201 gctgggccct ttctagatta cctcacaagg cgtgaggtgg cacgaaccaa tgaccccaac
     1261 accctcttcc gttctaactc cttggcatcc aagtcgatgg aacagttcat gaaactcgtg
     1321 ggcatgcgct acctgcatga ggtcctgagg ccggtgatca gccgcgtctt cgaggagaag
     1381 aaatatatgg agctggaccc ttccaagatg gacctgaacc gctcccggag aatctccttc
     1441 aagggcacac ccacggagga gcaggtgcgg gagaccagcc tggggctgct gaccggatac
     1501 ctggggtccg ttgtggacgc catcgtgagc tctgccgggc gctgcccact tgccctgcgc
     1561 ttagccttta agcaactcca gcagtgtgtg gagaagcgct tccctgggat ggagcatcag
     1621 gacgtgaagt acttggccac tagcggcttc ctctttctgc ggttctttgc gcccgccatc
     1681 ctcacaccga agctgtttga cctcagagac caccacgcag acccccagac cagccgctcc
     1741 ctgctgctgc ttgccaaggc tgtgcagagc attggaaacc tgggccagca gctgggccag
     1801 ggcaaagagc agtggctagc ccccctccat cccttcctgc tgcagagcat ctcacgtgtg
     1861 agggacttcc tggaccagct ggtggatgtg gatggggatg aggaggctgg gggatcaacc
     1921 tgcgccctgg tccaaccctc aacaattgtt cgagaaggct ttctgctgaa gcgcaaggag
     1981 gagcctgcaa gcctggccac ccgctttgcc ttcaagaagc gctacttccg actgagtggg
     2041 cgggacctct cctactctaa gactcctgag tggcaggttc actcatccat cccgttgtcc
     2101 tgcatccggg ctgtggagcg tgtggatgag ggtgccttcc aactgccaca tgtcatgcag
     2161 gtggtgacac aggatggcac cggggcatca cacaccacct acctccagtg caagaacgtg
     2221 aatgacctca atcaatggct gtcagccctg cgcaaagcca gcgcccccaa cccgggcaag
     2281 ctggctgctt gtcaccctgg tgccttccgc agcgggcgct ggacctgctg cctccaggcc
     2341 gagcgctcag ctgttggctg tagccgcaca cactcagctg tcacgctggg agactggagt
     2401 gacccactgg atcctgacgc cgaagcccag atggtgtatc gccagctgct cctgggccga
     2461 gaccagctca ggctgaaact gctggaggac tccagcctgg acacagctcc agatgtggac
     2521 cctgggaagg actccagtgc tgtagatggg ccctgtgctg aggttctagc ccagcagagg
     2581 gaggccacca cccgtctgct gcaggtactt gaagacttgg agcaagccca tgaggaattc
     2641 cagaaacggg gctaggggaa agtggccctc taggacactg gatgctgaga aggtgccaga
     2701 gccagttggg gacagagcca cggggcttcc ctgagcttac tttggcctag gcatcttcat
     2761 tgtcgtggct tggagcctcc caaagtgtgg tcctgtgtgc cctgtagcca gccagggcat
     2821 aggaaccttt aagagggccc agccttgtac cgactgacca aacctcactt ccttctctga
     2881 gcctggagcc tcagcttcac tggatacagc tcctccagta ccggtggaac ccataccggt
     2941 ggcacccatc tcaccccaag ctgctgggtg cagctgtacc tgaactccaa tcctggctga
     3001 tgcagaaaaa cactcaatat gcttgaccag gaacttcccg tgttatcact tccgtgggcc
     3061 ccggtgacct cacagatcct tctgtacccc actttcatct ggcagtcccg gcctcaagct
     3121 tctgggaccc ggtgttctcg gaagaacgga ctgggagccc agcatgccaa tttggagcct
     3181 cgaagctgga cacgggctct tcctccctcc tataccctgt ataaagtgac gtgtgagcat
     3241 gctta
//
LOCUS       NM_001037775            1715 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 12 (Chst12),
            transcript variant 1, mRNA.
ACCESSION   NM_001037775 XM_006248935 XM_221946
VERSION     NM_001037775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Prisco,S.Z., Prokop,J.W., Sarkis,A.B., Yeo,N.C., Hoffman,M.J.,
            Hansen,C.C., Jacob,H.J., Flister,M.J. and Lazar,J.
  TITLE     Refined mapping of a hypertension susceptibility locus on rat
            chromosome 12
  JOURNAL   Hypertension 64 (4), 883-890 (2014)
   PUBMED   25001272
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Hiraoka,N., Nakagawa,H., Ong,E., Akama,T.O., Fukuda,M.N. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of two distinct human chondroitin
            4-O-sulfotransferases that belong to the HNK-1 sulfotransferase
            gene family
  JOURNAL   J Biol Chem 275 (26), 20188-20196 (2000)
   PUBMED   10781601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_006248935.3, NM_001037775.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.42557.1,
                                           SRR26643289.31903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000012.1  19242868-19242930   c
            64-1715             JAXUCZ010000012.1  19224545-19226196   c
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1715
                     /gene="Chst12"
                     /note="carbohydrate sulfotransferase 12"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
     exon            1..63
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     exon            64..1715
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    108..110
                     /gene="Chst12"
                     /note="upstream in-frame stop codon"
     CDS             141..1400
                     /gene="Chst12"
                     /EC_number="2.8.2.5"
                     /note="carbohydrate (chondroitin 4) sulfotransferase 12"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 12"
                     /protein_id="NP_001032864.1"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
                     /translation="MTKPRLFRLWLALGSALMILLIIVYWDNVGTAHFYLHTSLSRPH
                     ILEPLPTQGLAEENVLASDVDEFLDTLLSSDAKHNDLSRRKTEQPPVLTPSKPVLSHM
                     EENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELN
                     HLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTH
                     LTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFA
                     VPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLC
                     HPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLA
                     WRQQLYKLYEADFVLFGYPKPENLLRD"
     misc_feature    633..1373
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
     misc_feature    633..1373
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
ORIGIN      
        1 agaatcagca gcctcagcaa cagcagcagc agcagcagcg gtggtgactg tagcgggcgc
       61 taggtccctc tcccagcacc atgtcccagc ggtacacaag gctgaagtga agggccaggt
      121 gtggccctgc ccagggcagc atgaccaagc cgcggctctt ccggctgtgg ctggcactag
      181 ggtcggccct catgattctt ttgatcattg tatattggga caacgtgggc actgcccact
      241 tctatctgca tacgtccctg tccaggccac acatcctaga accccttccc acccaggggc
      301 tggcagagga gaacgtgttg gcttccgatg tggacgagtt tttggacacg ctccttagtt
      361 ctgacgcgaa acacaacgac ctttccagga gaaaaactga gcagcccccg gtgctcaccc
      421 ccagcaagcc agtcttgagc cacatggagg agaacgtgag aggctacgac tggtccaccc
      481 atgatgccca gcagaaccca gaccgggaca ggcagcaggc cgagaggagg agcctgctga
      541 gggatttctg tgccaacgcc agcctggcat tccccaccaa ggaccgctct tttgacgaca
      601 tccccaacta cgaactgaac cacctgattg tggacgaccg ccacggggtc atctactgct
      661 acgtgcccaa ggtggcctgc accaactgga agcgagtgat gatcgtgctg agcgagagcc
      721 tgctggaccg gggcagcccc taccgagacc ccctggacat cccccgggag cacgtgcaca
      781 acaccagcac gcacctgacc ttcaacaagt tctggcgccg ctacgggaag ttctcccgtc
      841 acctcatgaa ggtcaagctg aagaagtaca ccaagttcct gttcgtgcgc gaccccttcg
      901 tgcgcctcat ctcagccttc cgcagcaagt tcgagctgga aaacgaggag ttttaccgca
      961 agttcgcggt gcccatgctc cggctgtacg ccaaccacac cagcctgccc gcctcggtga
     1021 gcgaggcttt cagcgcaggc ctcaaggtct ccttcgccaa cttcatccag tacctcctgg
     1081 acccacacac ggagaagctg gcgcccttca acgagcactg gcgacaggtg taccgcctct
     1141 gccacccgtg ccagatagac tacgacttcg tggggaagct ggagaccctg gatgaggatg
     1201 ctgcccagct cctgaggtcc ctcaaggtag actcccaact ccacttccct cccagttacc
     1261 ggaacaggac cgccagcagc tgggaggaag actggtttgc caacatcccc ctggcctgga
     1321 ggcaacagct ctataaactc tacgaggccg actttgttct ctttggctac cccaagccag
     1381 aaaacctgct cagggactga gctcccataa gccctcacgc tgccacaaga aactgagatg
     1441 gtcctttgag aatgggaccc cgtggcctcc tggttctctc ctggcttcct gtaccttccc
     1501 tggtgtagac aggcagagga tgacacaacc caagcacctc actctccaga gtttcgcgcc
     1561 ccacccccac ccccaccctt ttgcaatctg ggtttgttta ctccacagcc tgtactcatg
     1621 ggacactgtg ttaatactgt tttctacgat taatatattt cagatatatt taataagaaa
     1681 gtgggaggaa gctggagtaa agtgtggagc ccgca
//
LOCUS       NM_001107459            2493 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 17 (Rgs17),
            transcript variant 3, mRNA.
ACCESSION   NM_001107459 XM_001059287 XM_217837
VERSION     NM_001107459.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Dhukhwa,A., Al Aameri,R.F.H., Sheth,S., Mukherjea,D., Rybak,L. and
            Ramkumar,V.
  TITLE     Regulator of G protein signaling 17 represents a novel target for
            treating cisplatin induced hearing loss
  JOURNAL   Sci Rep 11 (1), 8116 (2021)
   PUBMED   33854102
  REMARK    GeneRIF: Regulator of G protein signaling 17 represents a novel
            target for treating cisplatin induced hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Sokolov,E., Iannitti,D.A., Schrum,L.W. and McKillop,I.H.
  TITLE     Altered expression and function of regulator of G-protein
            signaling-17 (RGS17) in hepatocellular carcinoma
  JOURNAL   Cell Signal 23 (10), 1603-1610 (2011)
   PUBMED   21620966
  REMARK    GeneRIF: RGS17 is differentially expressed in hepatocellular
            carcinoma cells and plays a central role in regulating transformed
            hepatocyte tumorgenicity.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474052.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217837.4, XM_001059287.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2493
                     /gene="Rgs17"
                     /note="regulator of G-protein signaling 17"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
     exon            1..158
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            159..231
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    221..223
                     /gene="Rgs17"
                     /note="upstream in-frame stop codon"
     exon            232..375
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..889
                     /gene="Rgs17"
                     /codon_start=1
                     /product="regulator of G-protein signaling 17"
                     /protein_id="NP_001100929.1"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
                     /translation="MRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVR
                     NEERGDSSGRPPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKAPAGRNLFREFL
                     RTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN
                     RNLLEPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTASSTSES"
     misc_feature    377..847
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     misc_feature    377..847
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     exon            376..465
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            466..700
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            701..2493
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcggctc tatcctggcc tctctccctc tctccgtcgc cgggtgctga agttgggcgg
       61 atggcaagga gcccgctccg ctagaggacg gaacagccca gccttgagca cactcggact
      121 cggacccggg gacggtcgcc cacatcccag gccacctggt ttattatata tactgcctaa
      181 ttcccatcaa gatatgtgat tcttcccaac aaattattgc taagatggca gccagtcgga
      241 ttctgaagca gctgacatga gaaaacggca gcagtcacaa aatgaaggca cgcaggctgt
      301 gtctcaagcg cccggaaacc aaaggcccaa caacacctgt tgcttctgct ggtgctgctg
      361 ctgcagctgc tcctgcctca ctgtcaggaa tgaagaaaga ggagactctt cggggagacc
      421 cccacacacc accaaaatgg agagcatcca ggtcctagag gaatgccaaa accccactgc
      481 agatgaagtc ttgtcctggt ctcagaattt tgacaagatg atgaaggctc ctgcaggaag
      541 aaaccttttc cgagagttcc tccgaacaga atacagcgag gagaacctac tcttctggct
      601 ggcctgtgaa gacttaaaga aggagcagaa caagaaagct gttgaagaaa aggccaggat
      661 gatatacgag gattacattt ctatactgtc accgaaagag gtcagcctcg attctcgagt
      721 tagagaggtg atcaacagga atctgctgga gcccagccct cacatgtacg aagatgccca
      781 gcttcagatc tacaccctaa tgcacagaga ttctttccca agattcttga actcgcagat
      841 ctacaaagcc tttgtcgaaa gtactgccag ctccacttct gaatcttaat tttcatttga
      901 aaggccaaaa aaaaaatcat ttcagagggc tgggatggga aataaaagta attaaataac
      961 atcagaaatc gagttcctga aaaaaacgac aggttggctg ctgggaaaag acaactggga
     1021 aagtcgtttg tctctatttt tatcaaggtt atccatgatt ctgttagggg gtaaaaagcc
     1081 tgtgtaagaa aatgagttgc caaattgagt ttgtttgatt caacacttgc tctccttgca
     1141 agcgaactat gttcctagtc ctctgaacaa tcccctagtg catctctaga ggccgcatgt
     1201 gcaaagtaaa accgcttcgt ctgcccttta cttgtgccat taagtcagta gcataccttg
     1261 tatctgtatt taaggacttc tgtgcaatat ggtctcttag aaacaattgc caacaaattg
     1321 gccgtggttt gcatttttta agcataatct gatacacaca aaggctattt taaacatgta
     1381 acagtgatat ttaaccacgc tacatactat gtttagtaca tggactctga agccaatttt
     1441 tctgtacatg ttaaaaaaaa aagtgaccat tgaaggacct tattgtgtga gacctctggt
     1501 tgttcactgc ccacattctg acatttttgt tacagaagag tttgctatat atatatttta
     1561 agagaaagaa aagagagaaa aagaaagaaa acaaaaatag ttaacaatga taagaaaaat
     1621 tttaaaaagc acaaaacaat ctgcagatat cctgtctcgt tgaaaattcc aagaaggata
     1681 ctatttttag gtctaaaaga aagaaaagag tctatgtata tatcagatgt ccaatagtgt
     1741 aattaattta tcaaagaaag gctcttcagt tctaaaagca ttgcataaac ctatgactgt
     1801 cagcaggtaa acaataataa gttcagtaac ccagtttggg aatagaacgg gaagggtaat
     1861 aaagaaatgc ctacatgtag cactgtaaaa gtcacctttg aggagtcgcc tctgtgtggc
     1921 gcgctcacct tgaacgtgta attcagtgaa aagcttgagt ttttcctaac caacatttta
     1981 caagggatta tagagaagaa agccttcgat gtcagacctt aactgttttc accgtagtct
     2041 ctcaagaaag acttattttt aacattgtta aaatcaaact accaaccctc gtccgtaact
     2101 agaaggcagt gcagtgctca atccttttag ctgccaatat tattttttat aattacatta
     2161 actctttaca cggatactca catgaccatg gtatgcattt ctgaccttca gaacagtatc
     2221 gtcttgtgca caaaaccaaa attacaatca atgtcatatt tatatcaagg tcctaccttt
     2281 caatatcaaa atcccctgga gactattttt ttaatcttaa actcaatgaa tatatgttga
     2341 gtaaccttta aaaaatgaaa gatttaaaaa gatttataac cactgagaat actggcctta
     2401 tattaaggat gatattaaaa ttaaaggttt tgtttgtcat ttttaactac ctctcagttt
     2461 ttaatttatt aaacatattt ttttaagatg caa
//
LOCUS       NM_001106361            1400 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus paired box 2 (Pax2), transcript variant 2, mRNA.
ACCESSION   NM_001106361 XM_001062747 XM_239083
VERSION     NM_001106361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Wang,X.L., Hou,L., Zhao,C.G., Tang,Y., Zhang,B., Zhao,J.Y. and
            Wu,Y.B.
  TITLE     Screening of genes involved in epithelial-mesenchymal transition
            and differential expression of complement-related genes induced by
            PAX2 in renal tubules
  JOURNAL   Nephrology (Carlton) 24 (2), 263-271 (2019)
   PUBMED   29280536
  REMARK    GeneRIF: Pax2 overexpression by kidney tubule cells alters the
            expression of complement system proteins to induce
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Hou,L., Du,Y., Zhao,C. and Wu,Y.
  TITLE     PAX2 may induce ADAM10 expression in renal tubular epithelial cells
            and contribute to epithelial-to-mesenchymal transition
  JOURNAL   Int Urol Nephrol 50 (9), 1729-1741 (2018)
   PUBMED   30117015
  REMARK    GeneRIF: PAX2 directly increased expression of ADAM10, the presence
            of which contributed to EMT in renal tubular epithelia and hence
            plays an important role in renal fibrosis.
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Larsson,M.
  TITLE     Pax2 is persistently expressed by GABAergic neurons throughout the
            adult rat dorsal horn
  JOURNAL   Neurosci Lett 638, 96-101 (2017)
   PUBMED   27939388
  REMARK    GeneRIF: Persistent Pax2 expression may be required to maintain a
            GABAergic phenotype.
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Jiang,Y., Jiang,T., Ouyang,J., Zhou,Q., Liang,Y., Cui,Y., Chen,P.
            and Huang,B.
  TITLE     Cell atavistic transition: Paired box 2 re-expression occurs in
            mature tubular epithelial cells during acute kidney injury and is
            regulated by Angiotensin II
  JOURNAL   PLoS One 9 (4), e93563 (2014)
   PUBMED   24710423
  REMARK    GeneRIF: Those findings suggest that mature TECs can
            trans-differentiate into progenitor-like cells by 'atavistic
            transition', which may participate in the recovery of tissue
            structure and Pax2 may play a pivotal role in this process.
            Erratum:[PLoS One. 2015 May 06;10(5):e0127718. doi:
            10.1371/journal.pone.0127718. PMID: 25945929]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Ryan,G., Steele-Perkins,V., Morris,J.F., Rauscher,F.J. 3rd and
            Dressler,G.R.
  TITLE     Repression of Pax-2 by WT1 during normal kidney development
  JOURNAL   Development 121 (3), 867-875 (1995)
   PUBMED   7720589
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Sharma,P.M., Bowman,M., Yu,B.F. and Sukumar,S.
  TITLE     A rodent model for Wilms tumors: embryonal kidney neoplasms induced
            by N-nitroso-N'-methylurea
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9931-9935 (1994)
   PUBMED   7937920
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_239083.4, XM_001062747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132274, SAMD00132279
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1400
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
     exon            1..75
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1283
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     paired box protein Pax-2; paired box gene 2; paired box
                     protein 2; paired box homeotic gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2 isoform 2"
                     /protein_id="NP_001099831.1"
                     /db_xref="GeneID:293992"
                     /db_xref="RGD:1305568"
                     /translation="MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELA
                     HQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYK
                     RQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAP
                     GHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKREEVEVYTDPAHIRGGG
                     GLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVF
                     QASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMAS
                     TTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLS
                     SPYYYSAAPRGSAPAAAAAAYDRH"
     misc_feature    75..449
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    75..449
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired Box domain; Region: PAX; smart00351"
                     /db_xref="CDD:128645"
     misc_feature    order(90..95,108..110,114..122,126..128,141..143,177..179,
                     183..185,210..212,219..221,225..230,240..242,267..287,
                     291..302,357..365,420..422,426..431,438..440,447..449)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    order(90..95,108..110,114..122,126..128,141..143,177..179,
                     183..185,210..212,219..221,225..230,240..242,267..287,
                     291..302,357..365,420..422,426..431,438..440,447..449)
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     misc_feature    942..1277
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     misc_feature    942..1277
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /note="Paired-box protein 2 C terminal; Region: Pax2_C;
                     pfam12403"
                     /db_xref="CDD:463563"
     exon            76..241
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..439
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..525
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..645
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..714
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..890
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1017
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1119
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1206
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1400
                     /gene="Pax2"
                     /gene_synonym="Pax-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgct gctcccgctc ctctgcctcc ccatggatat gcactgcaaa gcagacccct
       61 tctccgcgat gcaccggcac gggggtgtga accagctcgg gggggtgttt gtgaacggcc
      121 ggcccctacc cgacgtggtg aggcagcgca tcgtggagct ggcccaccag ggtgtgcggc
      181 cctgtgacat ctcccggcag ctgcgggtca gccatggctg tgtcagcaaa atcctgggca
      241 ggtactacga gactggcagc atcaagcccg gagtgattgg tggctccaag cccaaggtgg
      301 caacgcccaa agtggtggac aagattgctg aatacaagcg acagaacccg actatgttcg
      361 cctgggagat ccgggacagg ctgctagctg agggcatctg cgacaatgat acagttccca
      421 gcgtctcatc catcaacagg atcatccgga ccaaagttca gcagcctttc cacccaacgc
      481 cggatggggc agggacagga gtgactgccc ctggccacac catcgttccc agcacggcct
      541 cccctcctgt ttccagcgcc tctaacgacc cagtgggatc ctactccatc aacgggatcc
      601 tggggattcc tcgctccaac ggtgagaaga ggaaacgaga ggaagtcgag gtatacactg
      661 atcctgccca cattagagga ggtggaggtt tgcatctggt ctggacttta agagatgtgt
      721 ccgagggctc tgtccctaat ggagactccc agagtggtgt ggacagtttg cggaagcacc
      781 tgcgagccga caccttcacc cagcagcagc tggaagcttt ggatcgagtc tttgagcgtc
      841 cttcctatcc cgatgtcttc caagcatcag agcacatcaa atcagaacag gggaatgaat
      901 actctctccc agccctgacc cctgggcttg atgaagtcaa gtccagtcta tctgcatcta
      961 ccaaccctga gctgggcagc aatgtgtcag gcacacagac gtaccccgtc gtgaccggtc
     1021 gtgatatggc gagcaccact ctacctggtt acccccctca tgtgcccccc actggccagg
     1081 gaagctaccc tacctccacc ctggcaggaa tggtgcctgg gagcgagttc tcaggcaacc
     1141 catacagcca tccccagtac accgcctaca atgaggcttg gagattcagc aaccccgcct
     1201 tactaagttc cccttattat tatagtgccg ccccccgggg ctccgcccct gccgctgctg
     1261 ccgctgccta tgaccgccac tagttaccgc ggggaccaca tcaagcttca ggcagacagc
     1321 ttcggcctcc acatcgtccc cgtctgaccg cccaccccag agggagggag gaccgaagcg
     1381 acgcgctgcc tctcggccac
//
LOCUS       NM_001007687            2775 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus carnosine dipeptidase 1 (Cndp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001007687 XM_008772135 XM_225678
VERSION     NM_001007687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Chakkera,H.A., Hanson,R.L., Kobes,S., Millis,M.P., Nelson,R.G.,
            Knowler,W.C. and Distefano,J.K.
  TITLE     Association of variants in the carnosine peptidase 1 gene (CNDP1)
            with diabetic nephropathy in American Indians
  JOURNAL   Mol Genet Metab 103 (2), 185-190 (2011)
   PUBMED   21393041
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Kilis-Pstrusinska,K., Zwolinska,D. and Grzeszczak,W.
  CONSRTM   Study Group
  TITLE     Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic
            kidney disease progression in children and young adults? results of
            a family-based study
  JOURNAL   Arch Med Res 41 (5), 356-362 (2010)
   PUBMED   20851293
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S.,
            Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D.,
            Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C.
            and Smirnova,T.
  TITLE     Sequence identification and characterization of human carnosinase
            and a closely related non-specific dipeptidase
  JOURNAL   J Biol Chem 278 (8), 6521-6531 (2003)
   PUBMED   12473676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_008772135.4, NM_001007687.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.52841.1,
                                           SRR26643295.57032.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000018.1  80305653-80305785   c
            134-335             JAXUCZ010000018.1  80282443-80282644   c
            336-485             JAXUCZ010000018.1  80280876-80281025   c
            486-648             JAXUCZ010000018.1  80279338-80279500   c
            649-737             JAXUCZ010000018.1  80277825-80277913   c
            738-938             JAXUCZ010000018.1  80275787-80275987   c
            939-1023            JAXUCZ010000018.1  80273152-80273236   c
            1024-1184           JAXUCZ010000018.1  80267586-80267746   c
            1185-1349           JAXUCZ010000018.1  80264705-80264869   c
            1350-1491           JAXUCZ010000018.1  80263386-80263527   c
            1492-1639           JAXUCZ010000018.1  80261987-80262134   c
            1640-2775           JAXUCZ010000018.1  80259766-80260901   c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2775
                     /gene="Cndp1"
                     /note="carnosine dipeptidase 1"
                     /db_xref="GeneID:307212"
                     /db_xref="RGD:1359493"
     exon            1..133
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..335
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Cndp1"
                     /note="upstream in-frame stop codon"
     CDS             258..1736
                     /gene="Cndp1"
                     /EC_number="3.4.13.20"
                     /note="CNDP dipeptidase 1; carnosine dipeptidase 1
                     (metallopeptidase M20 family)"
                     /codon_start=1
                     /product="beta-Ala-His dipeptidase"
                     /protein_id="NP_001007688.1"
                     /db_xref="GeneID:307212"
                     /db_xref="RGD:1359493"
                     /translation="MLSPPHSGTLEKLFQYIDLHQDEFVQTLKEWVAIESDSVQPMPR
                     LRQELFRMMALAADKLRNLGARVDSVDLGSQQMPDGQSLPTPPIILAELGNDPKKPSV
                     CFYGHLDVQPAQKEDGWLTDPYTLTEVDGKLYGRGATDNKGPVLAWINAVSTFRALQQ
                     DLPVNVKFILEGMEEAGSVALEELVKREKDNFFSGVDYIVISDNLWLSQKKPALTCGT
                     RGNCYFTVEVKCRDQDFHSGTFGGILNEPMADLVALLGSLVDSSGHILVPGIYDQMAP
                     ITEEEKTMYENIDLDLEEYQKSSRVERFLFDTKEELLTHLWRYPSLSIHGIEGAFDEP
                     GTKTVIPGRVLGKFSIRLVPHMTPSVVETQVTQHLEAVFSKRNSFNKMAVSMVLGLQP
                     WTANINGTQYLAARRAIQTVFGVDPDMIQDGSTIPIAKIFQDITQKSVMMLPLGAVDD
                     GEHSQNEKINRWNYIQGSKLFAAFFLELSKLHSGQQVPSGAF"
     misc_feature    294..1700
                     /gene="Cndp1"
                     /note="M20 cytosolic nonspecific dipeptidases including
                     anserinase and serum carnosinase; Region:
                     M20_dipept_like_CNDP; cd05676"
                     /db_xref="CDD:349925"
     misc_feature    294..1700
                     /gene="Cndp1"
                     /note="M20 cytosolic nonspecific dipeptidases including
                     anserinase and serum carnosinase; Region:
                     M20_dipept_like_CNDP; cd05676"
                     /db_xref="CDD:349925"
     misc_feature    order(576..578,675..677,777..782,864..866,870..872,
                     909..911,1308..1310,1419..1421,1521..1523,1527..1535,
                     1614..1616)
                     /gene="Cndp1"
                     /note="active site"
                     /db_xref="CDD:349925"
     misc_feature    order(576..578,675..677,777..782,864..866,870..872,
                     909..911,1308..1310,1419..1421,1521..1523,1527..1535,
                     1614..1616)
                     /gene="Cndp1"
                     /note="active site"
                     /db_xref="CDD:349925"
     misc_feature    order(588..590,606..608,912..914,918..920,924..926,
                     930..932,948..959,963..995,999..1001,1011..1013,
                     1020..1025,1032..1040,1140..1142,1149..1157,1164..1169,
                     1191..1193,1200..1205,1218..1241,1251..1274,1278..1283,
                     1296..1298,1308..1310,1383..1388,1392..1394,1419..1421,
                     1524..1529,1611..1622)
                     /gene="Cndp1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349925"
     misc_feature    order(588..590,606..608,912..914,918..920,924..926,
                     930..932,948..959,963..995,999..1001,1011..1013,
                     1020..1025,1032..1040,1140..1142,1149..1157,1164..1169,
                     1191..1193,1200..1205,1218..1241,1251..1274,1278..1283,
                     1296..1298,1308..1310,1383..1388,1392..1394,1419..1421,
                     1524..1529,1611..1622)
                     /gene="Cndp1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349925"
     misc_feature    837..839
                     /gene="Cndp1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (Q66HG3.1); phosphorylation site"
     exon            336..485
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..648
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..737
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..938
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1023
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1184
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1349
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1491
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1639
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..2775
                     /gene="Cndp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctcat tggtgttcat caccaaagga agacaggacc agcactcaag cagatcagga
       61 agcagtgaaa gacccctgga gctgggagac tctcactcaa gtctcgggat gacacgaccc
      121 cccaagaact cacgcttcat ctcccgctgc actgctgctg cgggccaatc ataggcttca
      181 tctcttagtc actgctgctg tgggccaatc ataagcttcg tctctcctgg gcactgctgc
      241 tgcagctgga gcgcggaatg ttatctcctc cacactctgg gacgctggag aagctcttcc
      301 agtacataga cctccaccag gatgagtttg tgcagaccct gaaggaatgg gtggccattg
      361 agagtgattc tgtgcagccc atgcctcgtc tcagacagga gctcttccgg atgatggcct
      421 tagccgcaga caaactccgg aacctgggag ctagggtgga ttctgtagac ctgggttctc
      481 agcagatgcc tgacggtcag agtcttccca cgcctcctat catattggct gaacttggaa
      541 atgatcccaa gaagccctcc gtatgtttct atgggcacct ggatgtgcag ccagctcaga
      601 aggaggatgg gtggctcacg gacccctaca cactgacaga ggtggatggg aaactgtatg
      661 gacggggagc gacagacaac aaaggccctg tcttggcttg gattaatgcc gtgagcacct
      721 tcagagctct gcagcaggat cttcccgtga acgtcaagtt catcctggaa gggatggagg
      781 aagctggttc tgtcgccctg gaggaactcg tcaaaagaga aaaagacaac ttcttctctg
      841 gtgtggacta cattgtgatt tcagacaacc tgtggctcag ccagaagaag cctgcactca
      901 cttgtggaac ccgggggaac tgctacttca cggtggaggt aaagtgtaga gatcaagatt
      961 tccattccgg aacctttggt ggcatcctca acgaaccaat ggctgacctg gttgctcttc
     1021 taggtagcct ggtagattca tcaggccaca tcctagttcc tggaatctat gatcaaatgg
     1081 cccctattac agaggaggaa aagacaatgt atgaaaacat tgatctggac ctagaagaat
     1141 accagaagag cagccgggtt gaaagatttc tgtttgatac caaggaggag ctcctcacgc
     1201 atctgtggag atacccgtct ctctccatcc atggcatcga gggtgcattt gatgagcccg
     1261 gaactaaaac agtcattccc ggccgcgtcc taggaaaatt ttcaatccgt ctagtcccac
     1321 acatgactcc gtctgtggta gagacacagg tgacgcagca tctggaagcg gtgttctcaa
     1381 aaaggaatag tttcaacaag atggctgttt ctatggtact aggactccag ccgtggactg
     1441 caaacatcaa tggcactcag tacctcgcag cacgaagagc catccaaaca gtgtttggag
     1501 tcgatcctga catgatccag gatgggtcaa ccattccaat tgctaaaata ttccaggata
     1561 tcacccaaaa gagtgtgatg atgctcccgc tgggggctgt ggacgatgga gagcactccc
     1621 agaatgagaa gatcaacagg tggaactaca tacaagggtc gaaattattc gctgcctttt
     1681 tcctggagtt gtcaaagctt cattcaggac agcaggtgcc ttccggagca ttctgaccca
     1741 ccggcagatc tccccacctc agaccccccg gcaaagctgg aggagggaaa attcaggaaa
     1801 tgtggaaaat gaaatgtttg gaagcacaga tgctggagag attttaacag tccctctgtc
     1861 acttaacttt cacaagtctc agctacctgg ctggtcagtc cctgaaacca ctgtaaggct
     1921 gggactgcct tctagtgcag gtgggctgtc tcttcaggaa attaggttct cactttcact
     1981 tccattggct cagtcctcca gttcactttc caggcctgaa gagctatggt tcccaatcat
     2041 tggacctggg ggggtttcag gacctgagtc atcttcacct ctgtttcctt aataacggaa
     2101 gtggtggctt tcatcactgg ctagagtgat tttcccatgg attcaccttt agaagagtta
     2161 ctagaacatg tctcttgttc ttgcctcccc ttcatttatt ttctccagac tcttgaacat
     2221 tctgaagcta aacgatcagt attcataccc tcacaccgtt tggaatccct atgcaaagat
     2281 gaattgtttt ctttaattcc aaatttcttc agctttacct gctcagcccc tctgccgccc
     2341 atcctcccac tccgtcagta aagccccttc cctgcaaaca tgtgcacccg ccattctacc
     2401 agcaacattc accccaatgg aatttcacgc cattgaaatt ttgcctgatg agtttatttg
     2461 aattgcttaa agcttttaat aacgccagcg ttagatggag aactaatcag ccctgacatc
     2521 agcaagacat tctcgattta aagctctcag ctaaatctgc atccactaat cattttagtt
     2581 aactatcttg tttggctcga ttgggcttgg tggtgtaaac actataaaaa gttaattttt
     2641 ttttcttaca atcaagtgta tataaataaa ctgattcttc taagttcatt acttaaatcc
     2701 cgttaatagg aaagaacttg aaggcttatt tttaaatgct tctcttatgg ttccaaataa
     2761 aaacattcca taaca
//
LOCUS       NM_001109062            3893 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 146 (Gpr146), mRNA.
ACCESSION   NM_001109062 XM_001065344 XM_006248957 XM_573364
VERSION     NM_001109062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3893)
  AUTHORS   Jiang,Y., Huang,J., Xia,Y., Sun,Z., Hu,P., Wang,D., Liu,Y., Tao,T.
            and Liu,Y.
  TITLE     Hypoxia activates GPR146 which participates in pulmonary vascular
            remodeling by promoting pyroptosis of pulmonary artery endothelial
            cells
  JOURNAL   Eur J Pharmacol 941, 175502 (2023)
   PUBMED   36638952
  REMARK    GeneRIF: Hypoxia activates GPR146 which participates in pulmonary
            vascular remodeling by promoting pyroptosis of pulmonary artery
            endothelial cells.
REFERENCE   2  (bases 1 to 3893)
  AUTHORS   Martin,J.H., Aitken,R.J., Bromfield,E.G., Cafe,S.L.,
            Sutherland,J.M., Frost,E.R., Nixon,B. and Lord,T.
  TITLE     Investigation into the presence and functional significance of
            proinsulin C-peptide in the female germlinedagger
  JOURNAL   Biol Reprod 100 (5), 1275-1289 (2019)
   PUBMED   30715203
REFERENCE   3  (bases 1 to 3893)
  AUTHORS   Yosten,G.L., Kolar,G.R., Redlinger,L.J. and Samson,W.K.
  TITLE     Evidence for an interaction between proinsulin C-peptide and GPR146
  JOURNAL   J Endocrinol 218 (2), B1-B8 (2013)
   PUBMED   23759446
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_006248957.5, NM_001109062.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.40634.1,
                                           SRR26643292.47235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840127
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000012.1  20380911-20380973   c
            64-3893             JAXUCZ010000012.1  20365790-20369619   c
FEATURES             Location/Qualifiers
     source          1..3893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..3893
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="G protein-coupled receptor 146"
                     /db_xref="GeneID:498153"
                     /db_xref="RGD:1560731"
     exon            1..63
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /inference="alignment:Splign:2.1.0"
     exon            64..3893
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    80..82
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="upstream in-frame stop codon"
     CDS             89..1090
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 146"
                     /protein_id="NP_001102532.1"
                     /db_xref="GeneID:498153"
                     /db_xref="RGD:1560731"
                     /translation="MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLFYLGAGVPVGLGYN
                     ALLVLANLASKNSMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHV
                     TLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFS
                     SLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTP
                     LDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLVSRGRTVEGHYLGILQVAK
                     DLAKFLAFSSSSVTPLLYRYINKAFPSKLRRLVKKIHCGRRHCSPDPAGIQQVMAQA"
     misc_feature    167..1003
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="G protein-coupled receptor 146, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR146; cd14990"
                     /db_xref="CDD:320121"
     misc_feature    167..1003
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="G protein-coupled receptor 146, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR146; cd14990"
                     /db_xref="CDD:320121"
     misc_feature    170..250
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320121"
     misc_feature    170..250
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320121"
     misc_feature    269..343
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320121"
     misc_feature    269..343
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320121"
     misc_feature    order(332..334,341..346,392..409,413..418,425..427,
                     551..553,557..571,635..637,644..652,656..664,668..673,
                     821..823,830..835,839..841,848..850,902..907,911..919,
                     926..928,935..940)
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320121"
     misc_feature    order(332..334,341..346,392..409,413..418,425..427,
                     551..553,557..571,635..637,644..652,656..664,668..673,
                     821..823,830..835,839..841,848..850,902..907,911..919,
                     926..928,935..940)
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320121"
     misc_feature    389..481
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320121"
     misc_feature    389..481
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320121"
     misc_feature    512..577
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320121"
     misc_feature    512..577
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320121"
     misc_feature    635..718
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320121"
     misc_feature    635..718
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320121"
     misc_feature    761..850
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320121"
     misc_feature    761..850
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320121"
     misc_feature    905..982
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320121"
     misc_feature    905..982
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320121"
ORIGIN      
        1 gttgcctcct gcaagcccag ctgcccgccc gcggccggtg agcgggccgc cgcccagcga
       61 gcgagctgcg aagctggggt gagctgccat gtggagctgt ggcccactca acagcacagc
      121 gtgggctgag gagccgctgt gccggaacct gcgcctgggg ctgtgggtcc tctcactgtt
      181 ctacctgggg gcaggtgtcc ctgtgggctt aggctacaat gctcttttgg tgctggccaa
      241 tctggccagc aagaacagca tgaccatgcc tgatgtgtac ttcgtgaaca tggctgtggc
      301 ggggctggtg ctcacagcac tggcacctgc gtacctgctg ggtcctgccc actccaggtg
      361 ggccctgtgg agcctcagca gcgaggccca tgtgacactg ctcatcctgt tcaacgtggc
      421 ttccctggtg accatgtact ccactgcact gctgagtctt gactactaca tcgagcgtgc
      481 cctgccgcgt acctacatgg ctagtgtgta caacacccgg cacgtgtgtg gcttcgtctg
      541 gggaggggca gtgctcacca gcttttcctc cctgctcttc tatatctgca gtcatgtgtc
      601 ttctagaatt gccgagtgtg cccggatgca gaacacggag gcagccgacg ccatccttgt
      661 gctcattggc tacgtggtgc caggtctggc tgtgttgtat gccctggcac tcatctcaag
      721 gattgggaag gaagacacac ccctggacca ggacaccagc aggctggacc cctcagtgca
      781 caggctgctg gtggccactg tgtgcacaca gtttggcctc tggacacctt actacctgag
      841 cctggggcac acagtgctag tgtcacgggg aaggaccgtg gaggggcatt atctgggcat
      901 cctacaggtt gctaaggacc tggcaaagtt cttggccttc tcaagcagtt ctgtgacgcc
      961 gctgctctac cgttacatca acaaagcctt ccccagcaag ctccggcgcc tggtgaaaaa
     1021 gatacactgt gggcgccgcc actgctcccc cgaccctgcg gggatacagc aggtgatggc
     1081 ccaggcgtag ctgaccctct ctgggccgac gtccaaggag agggcctgac catgaggaac
     1141 actaaaactc aactggacgc atagcacttt gttccccaag cacatggtgc ttccaaccca
     1201 aaagacacgc cgaagccaga gtagcacagc agggcatttc tcttgacatt ttctgtgttt
     1261 tcccctaaaa gaccaatctt ggtcttaagc tgcattgtgg aaagcagagg tgccttctgt
     1321 gaagaggctg cttctaacta accctcacca tcccacccac ggtgtgtgcc tttctcccag
     1381 gggcatcttc aaggtccatg tcctcaaaag caggctgacc tttggtttcc ctgatatttg
     1441 gactttctaa atgaagcgat gaaatctaaa gccagtattt atactccata ttgatatgat
     1501 acttgattct cctattattt ttttaaatag aaagaagtgt tagaaaaata cctagtatta
     1561 agaagaaggc agttcagggg aacacggctg tcgcaaatac cagtgttaca gcttgaggac
     1621 aggacagtgt gtcaaacctg tggcagctcc acagccactg ctgacagtga cagctatggt
     1681 gcactggccc tgtccccacc cacacatctg gcacctctcc tctactgcgt gaggatctta
     1741 gtataggtct gtcttcccaa tgcttccaca tatgcacata aataatggaa ggaaaagtgt
     1801 gttctcttag tgccagcggt cttccagaga tctggatgtg gtaaagtgtt agccaggcat
     1861 ggaagggaaa ggcaggatgg tatgaggcta ggcgctccaa gatgacaagg gactggcatc
     1921 cagggaaagc ccagcttggc cagtcccaca cggctgtggg gtggttcgca atgaggctca
     1981 cctctcacag gttcctctgg gccttttacc atccttgtgt ttggtgatta tttactctaa
     2041 cgtgggcatg aaaagaagtc ccacaccagc cttgtctagg ttacatggca gtccacaagt
     2101 ccctgctcct agttctaaag atctccatgt gaccatctaa cctgacagcc tctacagaag
     2161 gccagtgtgt gatccatagc cggtggcctt cccacatggt tccagggctg gtcctggctg
     2221 ctccgagtcg gtaactttag ttttatctat tctatgcaaa ctatatcttc ttggatggtg
     2281 actgctccag ttaatctgcc ttaaggagaa ttagggagaa acatgaggcc ctcagctcat
     2341 gaataaacca aagggctggg ttagacaggc gtcttcagag ttgcttatgg ctgaagaatt
     2401 ttgaggactt taaagtggca atgcctgatt ttcctaccat tcccccaggc gcacagctga
     2461 gtgagggctc tgaggcttcc catcctgatg gccatactga acaccttaat gcttgccaaa
     2521 gaaacaagaa ccctcaccat gaataatcta gctaggcctg gcctacaggc ccgctataat
     2581 tgtcctatgg gtgagagcaa gcccagggac caaggtcaag gcaagcaaaa ggcaacctaa
     2641 actctgtggg tcacagagga aacaggattc tggtgggcag ggctgtttgc agtgtcaggt
     2701 cccagttcaa cggtctttgc cctgtggacc attttgcacc ctttgctaca agcagaggtc
     2761 caggggaggg gcagacccca ggtctagggg ttctatgccc tggaatcctc accccagtca
     2821 cccacaagca aggtggggga ggcccaaatc atgttcctct gctgtacctt ctcagtggcc
     2881 ttaggtacag actggctagg ttcttgggga cctgtgaggg attggaagcc aggaccagag
     2941 ctgtgagaat gagatcaact gtatggctac ttgctgcagg gataacagtg gagacccaga
     3001 tgcctacctg ggtcttcctg gtggggccac acatcaccag agtagtggcc atctgcagtg
     3061 ctgatccctt tgctgtagag acccctggag tgatgcaccc ttccacccgg ggccccattc
     3121 ccacccccac cagcctcctc cttaccccag ctttccatca cagccgccca cgctctgtag
     3181 gccctgggct cggatgtttg ctgtctgtga tcctgtgcta agttcactgt gtgtctccag
     3241 ggtctgcctc ccaattctgc cctgcacctt gcaccttcca aagtaggaga gaacctaaac
     3301 cacacagagg ttactgcgtg cgtgcgtgcg tgcgtgcgtg cgtgcgtgcg tgcgtgcgtg
     3361 tgtgtgtgtg tgtgtgtgcg tgcgcgcgcg cgcagctgtg ctttcttgcg tgagtttaag
     3421 acttccccaa ggcatactct tccccaaggc ttgttagttt ggccgttgac accgtcttga
     3481 tggttttatt tacaacgaat gttcttattt tcattcactc ataagaaagc ttgctgtgcg
     3541 tcattattca ggatcccaga aagggacctt tttcttgggt ttccttcaca atgccacatg
     3601 acgcgacata ggaaaccatt gctcactgga gcagatatgc ccaggaacca ccagacacct
     3661 cttctgtaga gaaagctttc agcaaaggtc aggccagaga gaacttagga caataaactg
     3721 cgtgtctggt tttgggtttt gaagcctgtg ggaagatgtg ggtgttctca ctcctttcct
     3781 acaggatata ccccagtggc tgggtccatt tgccgaaatt ctgtgaatgt gaaaaagaaa
     3841 ctactgatga gagtcacact tctgaagact attaaattat ttaacactca tca
//
LOCUS       NM_001105938            2990 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 4 (B3gnt4), mRNA.
ACCESSION   NM_001105938 XM_001079276 XM_222292
VERSION     NM_001105938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Shiraishi,N., Natsume,A., Togayachi,A., Endo,T., Akashima,T.,
            Yamada,Y., Imai,N., Nakagawa,S., Koizumi,S., Sekine,S.,
            Narimatsu,H. and Sasaki,K.
  TITLE     Identification and characterization of three novel beta
            1,3-N-acetylglucosaminyltransferases structurally related to the
            beta 1,3-galactosyltransferase family
  JOURNAL   J Biol Chem 276 (5), 3498-3507 (2001)
   PUBMED   11042166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced NM_001105938.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1136026.1,
                                           SRR26360194.2452530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000012.1  38734660-38734691   c
            33-2990             JAXUCZ010000012.1  38729653-38732610   c
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2990
                     /gene="B3gnt4"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 4"
                     /db_xref="GeneID:288752"
                     /db_xref="RGD:1309612"
     exon            1..32
                     /gene="B3gnt4"
                     /inference="alignment:Splign:2.1.0"
     exon            33..2990
                     /gene="B3gnt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1092
                     /gene="B3gnt4"
                     /EC_number="2.4.1.149"
                     /codon_start=1
                     /product="N-acetyllactosaminide
                     beta-1,3-N-acetylglucosaminyltransferase 4"
                     /protein_id="NP_001099408.1"
                     /db_xref="GeneID:288752"
                     /db_xref="RGD:1309612"
                     /translation="MLRRLGCVLFCTLVVLLLGCLLFLKERTPAGSSEAHQHFLAPPR
                     PHHSQCSPNLTVVNTSLSLPSRHRLFLTYRHCRNFSILLEPSECARDIFLLLVIKSQP
                     AHIEQRAAIRSTWGRGGSWARGRQLKLVFLLGVAGPVPPAQLLAYESWQFDDILQWDF
                     AEDFFNLTLKELHVQRWIAAACTQAHFILKGDDDVFIHVPNVLEFLEGWDPAQDLLVG
                     DVIRLARPNRNTKVKYFIPFSMYRARHYPPYAGGGGYVMSQATVRHLHTAMEEAELFP
                     IDDVFVGMCLRKLGVTPIHHAGFKTFGIQQPLNPRDPCLYRGLLLVHRLSPLEMWTMW
                     ALVTDERLECAARKP"
     misc_feature    358..927
                     /gene="B3gnt4"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     misc_feature    358..927
                     /gene="B3gnt4"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
ORIGIN      
        1 ttgtgcggtg cctgcttccc aggggagcct agggctccga ctatgttgcg caggctgggc
       61 tgtgtgctgt tctgcactct tgtggttctg ctgctcggct gcctgctctt tctgaaggag
      121 cgaacaccag caggcagctc tgaggcccac cagcacttct tggcaccgcc aaggccccac
      181 cacagccagt gctcacccaa cctaacagtt gttaacacct ccctgtccct gcccagccgt
      241 catcgcctct tcttaaccta tcgtcattgc cgaaacttct ccatcttgct ggagccttcg
      301 gagtgtgcca gggacatctt cctgctcctg gtcatcaagt ctcagccggc tcatattgaa
      361 cagcgtgcag ccattcggag cacttggggc cggggtggga gctgggctag aggccggcaa
      421 ctgaagctgg tgttcctcct gggggtggca ggacctgtgc ccccagccca gctgctggcc
      481 tatgagagtt ggcagttcga tgacatccta cagtgggact tcgctgagga cttcttcaat
      541 ctgaccctca aggagctgca tgtgcagcgc tggatagccg ctgcctgcac acaggcccac
      601 ttcatactaa agggggacga tgatgtcttt atccatgttc ccaatgtgct tgagttcttg
      661 gagggctggg atccagccca ggacctcctg gtgggagatg tcatccgcct ggctcggccc
      721 aacaggaaca ccaaagttaa atatttcatc ccgttttcca tgtacagggc ccgccactat
      781 ccaccttatg caggaggtgg aggctatgtt atgtcccagg ccactgtgag gcatcttcac
      841 acagccatgg aggaggcaga actcttcccc attgatgatg tctttgtggg gatgtgcctg
      901 aggaagctgg gggtgactcc catacaccat gctggcttca agacatttgg aatccaacag
      961 cccctcaacc ccagggaccc ctgtctgtac agagggctcc tgctggtgca ccgtctcagc
     1021 cccctggaga tgtggaccat gtgggcactg gtgacagatg agaggctgga gtgtgcagct
     1081 cgcaaaccct agccatgagg cgtgggctga gcaaagcttt agtgattgaa ctcctgtcac
     1141 caggagagac tactgaaaac tggtccctgc aggtcagcag aagtgatcta tttttataat
     1201 gccaccaacc ttaattgatt aaaactcttc cagcctggaa aatttgtcca gcatgtgctg
     1261 aaatgggagt gtgtgctgcc aggagcctta ggagaatcca gggccctata actcccaccg
     1321 ccttggccat gaaggaaaga cgctgcacga cagcccagaa gacttttttt tttttttaat
     1381 gcaaacacca aacttctctt cctttggata cagcagagaa attcaaaaaa ggaacgaaca
     1441 agaagcacgt gttggagaag gtgctgtggg gagcaccagg ggaactgttc acactgagta
     1501 acgccttagc tgagctgtgc tcacagggag aaaggacatt ataaacacaa agaaatgtta
     1561 caaaccagac aagcttccct gtggaggagc aagcagtaat tcatacttga acatctgagt
     1621 aacagtaaaa actggagtta aacagctatt gaacttaagg gtgtggcaga aaaggcccct
     1681 cctccattgg ccccggttgg tgaagtgctt tgggagtgag gtaaaagatc aagagagaag
     1741 ctgtgtgagg gacagtgcag agccaggccc agagaggctg cgagcagaga gaaggggcca
     1801 ggcgcagctc gcaaaggctc tggtctgact gtcaatggca gaaccggtca gcttctgcag
     1861 ttgggacgtc actgggtgga tgtcatgcac ctgctttccc cacagagtgg atggacaggg
     1921 cactgggctc gagccctcaa tcttctcgta ggtaggcctc ctcttcctgg tccgctgcct
     1981 catcgctcgc ttcctgtgtt ttctggcgca gctcttgtgt ctgcacttct gccagcttgg
     2041 tttccgcctt ctgggagagc tggcgcacct cctgcacctg cgacttcacc aactggatgt
     2101 gattcctggc ggttatagag gcctgatctg ctcctgtcaa aagaggacat ttgtactgag
     2161 cgccacagca aggacagaag tcacacacga aggcctgaag ctggcagctc ggctctcgtg
     2221 tggtcacctt cctgaccctc tggcttctga gttgaggttt gcatcttatt tcttttgagg
     2281 tggggtactg ggtgctggag agctgtgtgg tcatgagtgc gtgctattcc agaggctggg
     2341 gagtgccatt aggtggctca cagctacctt tacaactcaa gctgcagggg atctgatgcc
     2401 ctagactctg gggacgcctg cactcatagg ctctgaattg ttcagacaaa aaactgtggt
     2461 ctccctatac atcccaagct ggccttgaat ttccgcctgc ctcagcccta agggccacag
     2521 cacgcccagg tgaggctaat tcgcacacgc tggtgtggct gtgctcagct gtcactgcat
     2581 ctgacttaca gctctagttg ggagccagtc agactcgact gttagtttcg agccacctgg
     2641 gaccagtttg gtgtctgtgc tgttggtgtc acagattctg ctacaggctc gtcaggactg
     2701 agcctgggct ggttaggtca gcgaggcgag ccctcaggag atgagggacc cagccccgtg
     2761 gatgcactgc aggtgggtgc tggacatccg aacaacgcgc atgttacaga ctgagccact
     2821 ccaacctgga atttttgttt ttgaatatct aactcttccc tcaaaataac tgggcgtggt
     2881 gtccatcaca tccataggct cctcagccta tctggaatgt tgatggggtg gctggtcttt
     2941 ggagggatga tgctcatact taacactttc ctcctaaggg agaaaccaaa
//
LOCUS       NM_001107512            2135 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus TEA domain transcription factor 2 (Tead2),
            transcript variant 3, mRNA.
ACCESSION   NM_001107512 XM_001080702 XM_218630
VERSION     NM_001107512.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Tamm,C., Bower,N. and Anneren,C.
  TITLE     Regulation of mouse embryonic stem cell self-renewal by a
            Yes-YAP-TEAD2 signaling pathway downstream of LIF
  JOURNAL   J Cell Sci 124 (Pt 7), 1136-1144 (2011)
   PUBMED   21385842
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Tian,W., Yu,J., Tomchick,D.R., Pan,D. and Luo,X.
  TITLE     Structural and functional analysis of the YAP-binding domain of
            human TEAD2
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7293-7298 (2010)
   PUBMED   20368466
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Bhattaram,P., Penzo-Mendez,A., Sock,E., Colmenares,C., Kaneko,K.J.,
            Vassilev,A., Depamphilis,M.L., Wegner,M. and Lefebvre,V.
  TITLE     Organogenesis relies on SoxC transcription factors for the survival
            of neural and mesenchymal progenitors
  JOURNAL   Nat Commun 1 (1), 9 (2010)
   PUBMED   20596238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Zhang,H., Liu,C.Y., Zha,Z.Y., Zhao,B., Yao,J., Zhao,S., Xiong,Y.,
            Lei,Q.Y. and Guan,K.L.
  TITLE     TEAD transcription factors mediate the function of TAZ in cell
            growth and epithelial-mesenchymal transition
  JOURNAL   J Biol Chem 284 (20), 13355-13362 (2009)
   PUBMED   19324877
  REMARK    Erratum:[J Biol Chem. 2019 Apr 12;294(15):5808. doi:
            10.1074/jbc.AAC119.008436. PMID: 30979850]
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Zhao,B., Ye,X., Yu,J., Li,L., Li,W., Li,S., Yu,J., Lin,J.D.,
            Wang,C.Y., Chinnaiyan,A.M., Lai,Z.C. and Guan,K.L.
  TITLE     TEAD mediates YAP-dependent gene induction and growth control
  JOURNAL   Genes Dev 22 (14), 1962-1971 (2008)
   PUBMED   18579750
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Sawada,A., Nishizaki,Y., Sato,H., Yada,Y., Nakayama,R.,
            Yamamoto,S., Nishioka,N., Kondoh,H. and Sasaki,H.
  TITLE     Tead proteins activate the Foxa2 enhancer in the node in
            cooperation with a second factor
  JOURNAL   Development 132 (21), 4719-4729 (2005)
   PUBMED   16207754
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Kaneko,K.J., Rein,T., Guo,Z.S., Latham,K. and DePamphilis,M.L.
  TITLE     DNA methylation may restrict but does not determine differential
            gene expression at the Sgy/Tead2 locus during mouse development
  JOURNAL   Mol Cell Biol 24 (5), 1968-1982 (2004)
   PUBMED   14966277
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Milewski,R.C., Chi,N.C., Li,J., Brown,C., Lu,M.M. and Epstein,J.A.
  TITLE     Identification of minimal enhancer elements sufficient for Pax3
            expression in neural crest and implication of Tead2 as a regulator
            of Pax3
  JOURNAL   Development 131 (4), 829-837 (2004)
   PUBMED   14736747
  REMARK    Erratum:[Development. 2004 Mar;131(5):1195]
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Yockey,C.E. and Shimizu,N.
  TITLE     cDNA cloning and characterization of mouse DTEF-1 and ETF, members
            of the TEA/ATTS family of transcription factors
  JOURNAL   DNA Cell Biol 17 (2), 187-196 (1998)
   PUBMED   9502435
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Yasunami,M., Suzuki,K., Houtani,T., Sugimoto,T. and Ohkubo,H.
  TITLE     Molecular characterization of cDNA encoding a novel protein related
            to transcriptional enhancer factor-1 from neural precursor cells
  JOURNAL   J Biol Chem 270 (31), 18649-18654 (1995)
   PUBMED   7629195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218630.4, XM_001080702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168947.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2135
                     /gene="Tead2"
                     /note="TEA domain transcription factor 2"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
     exon            1..110
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..348
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1454
                     /gene="Tead2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     Embryonic TEA domain containing factor; TEA domain family
                     member 2; transcriptional enhancer factor TEF-4"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-4 isoform 1"
                     /protein_id="NP_001100982.1"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
                     /translation="MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGV
                     WSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSS
                     HIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATEL
                     FQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAW
                     QARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYD
                     KFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESR
                     ELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNFLHKLRQLP
                     ERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD"
     misc_feature    234..437
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    234..437
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    795..1442
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     misc_feature    795..1442
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     exon            349..413
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..476
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..584
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..643
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..708
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..851
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1025
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1187
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1340
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..2135
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgggctc tttgttctgt cctccagatg gctgggcgac tgagtcccaa ggcctgaagt
       61 ttgatgggcg ccccagcccc gcctccacct ggttctgtgg ttactttctg gcccagatgg
      121 gggatccccg gactggggcc cccctggatg atggcggggg ctggacaggt agtgaggaag
      181 gcagcgagga gggcactgga ggcagtgaag gtgttggagg tgatgggagc cccgatgcag
      241 aaggtgtgtg gagccctgac atcgagcaga gttttcagga ggccctggca atctaccctc
      301 cctgtggccg tcgcaagatc atcttgtcag atgagggcaa gatgtatggc cggaacgaac
      361 tcatcgcccg ttacatcaag ctgaggacag ggaagaccag aactcgaaag caggtctcta
      421 gtcacatcca ggttttggct cgaaggaaat cgagagaaat tcagtccaag ctgaaggacc
      481 aagtctccaa ggacaaggcc ttccagacga tggccaccat gtcttcggca cagctcatct
      541 ctgcaccttc tctccaggcc aagctgggtc cttctggccc tcaggccacc gagcttttcc
      601 agttctggtc agggagctct gggccaacat ggaatgttcc agacgtgaag cccttctcac
      661 aagcaccgtt ctccatgtca ctgacgcccc cagccactga cctaccaggg tacgagccgc
      721 ccccagccct ctcaccccta cccccacccg ccccatctcc cccagcctgg caggctcggg
      781 ccctgggcac tgcgcgcctg cagctggtag agttctcagc gtttgtggag ccgccagatg
      841 cagttgactc gttccagagg catctgtttg tccacatcag tcagcagtgc cccagccctg
      901 gagccccacc cctggagagt gtggacgtgc ggcagatcta cgacaaattc cctgagaaaa
      961 agggcggtct ccgggagctg tatgaccggg ggccaccaca tgcctttttc ctggtcaagt
     1021 tctgggcgga cctgaactgg ggcccaagtg ccgaggaggc agggaacagc ggaggtgctg
     1081 gtggcttcta cggagtgagc agccagtacg agagccgaga gctcatgaca ctgacctgct
     1141 cctccaaggt ctgctccttt ggcaagcaag tggtggagaa ggtggagaca gagcgggccc
     1201 agctggaggg cgggcgcttt gtgtaccgcc tgctgcgctc tcccatgtgt gagtacctgg
     1261 tcaacttcct gcacaagctc cgtcagctgc ctgagcgcta catgatgaac agcgtcctgg
     1321 agaacttcac catcctccag gttgtgacaa atagggacac tcaggaactg ctgctgtgta
     1381 ctgcctacgt ctttgaagtc tccaccagtg aacgcggagc ccagcaccac atctaccgcc
     1441 tggtcaggga ctgatggggc cccattgctg ctgtttatcc gaacaccccc ttcctaggaa
     1501 gggcccttct gctctccctg taagagagat gtggagaggg gcccatgatt tttaaaaagg
     1561 cctcatctca gaagcaatgg gggctggctt ctattagaaa ggcacccgaa gcttggcagc
     1621 gaagggagct gggtttgagt ttagatcccc aacacgagga cctcacagag aacctttgac
     1681 aggacacacc actcctgagc atcagggatt gaggatagga gtgcatgcgc acaggtacgc
     1741 ggcctctcca ctctacaggg gcccctcctt gctcttctgg aaaggggagc tcagctatgt
     1801 ggggcctctt actcattgcc ttataccctt cctgttttcc agtggtctca tgtctgcccc
     1861 tcccccacac cctttctctg ggatctgtaa tgttacaaac cgaagataat ggtttcccag
     1921 cttgaggtag agtgaagtgg gacctgaaaa attgttttaa tataaggaga tatttataca
     1981 cagtgttagg gatgtaatct tatctcagct aggcagtggg gtgggacttc ttaatctccc
     2041 cccaccccat tcaagtgagc cgtggaccac cctgccacct tcccttcccc aagagtgatg
     2101 gtttatgttt gaaggagaat aaaactattt ttacc
//
LOCUS       NM_001437595             857 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus CDC42 effector protein 5 (Cdc42ep5), transcript
            variant 2, mRNA.
ACCESSION   NM_001437595 XM_008758945
VERSION     NM_001437595.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 857)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   2  (bases 1 to 857)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2025 this sequence version replaced XM_008758945.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1452369.1,
                                           SRR26360190.2088372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               JAXUCZ010000001.1  79108335-79108595
            262-857             JAXUCZ010000001.1  79109955-79110550
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..857
                     /gene="Cdc42ep5"
                     /note="CDC42 effector protein 5"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
     exon            1..261
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    241..243
                     /gene="Cdc42ep5"
                     /note="upstream in-frame stop codon"
     exon            262..857
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..723
                     /gene="Cdc42ep5"
                     /note="isoform 1 is encoded by transcript variant 2; CDC42
                     effector protein (Rho GTPase binding) 5"
                     /codon_start=1
                     /product="cdc42 effector protein 5 isoform 1"
                     /protein_id="NP_001424524.1"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
                     /translation="MALLKQVGPAQPKKRLERGALSISAPLGDFRHTLHVGSSGDAFG
                     DTSFLNRHGGGPPPEAGAPPVVAPHSVPPPAVPQASVPGLRVPSPADPLLSFHLDLGP
                     SMLDAVLGVMDAERGETTATKPSGDALTGMQHPNAHCCSNADFQLDDVIGL"
     misc_feature    328..>411
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    328..>411
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    <469..600
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
     misc_feature    <469..600
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
ORIGIN      
        1 tggcttccac tatgctcagt cctgatctcc acctaccccc acaatccctt caaagggcct
       61 ttaggtttac taccaacaag gctttctagt cctttaaatc ctagaggcaa attttgaggg
      121 aataaggaag gttgggaggg gcctatggct taaccctctc agtctgggac aagaggccaa
      181 ctctcactgg gcgttgactc ggtgttgggt tgggaggctg ctatggcccc cgagaggggc
      241 tgaagcttat tcccggtgca gatggcgttg ttgaagcagg tgggccctgc acagccaaag
      301 aagcgactgg agcgtggagc actctctatc tcagcacccc ttggagactt caggcacaca
      361 ttgcacgtgg gaagcagtgg cgatgccttc ggagacacct cattcctgaa taggcacggg
      421 ggtggtccac ctccggaggc tggagcccca ccagttgtgg ccccacattc tgtccctcca
      481 cctgcagttc cacaggcctc tgtgcctggt ctccgagttc cttcacctgc agacccgcta
      541 ctgtccttcc acctggacct gggcccctct atgctggacg cagtgttagg cgtcatggac
      601 gcggagcgcg gcgagacgac ggccaccaag cccagtgggg atgccctcac tggaatgcag
      661 catcccaatg cccactgctg ctccaatgct gacttccagc tggatgatgt cattggtctg
      721 tagtatcttg attcccgcaa ctcctccctc cctgcactcc acttttgtac acataaatag
      781 ccgagtttta cgcgggaagg ggtgcagaag caggacagtg gtggggtgcc accaactaaa
      841 agtcaaatct gtcctca
//
LOCUS       NM_001437662            1885 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus transmembrane protein 237 (Tmem237), transcript
            variant 1, mRNA.
ACCESSION   NM_001437662 XM_006244975
VERSION     NM_001437662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Huang,L., Szymanska,K., Jensen,V.L., Janecke,A.R., Innes,A.M.,
            Davis,E.E., Frosk,P., Li,C., Willer,J.R., Chodirker,B.N.,
            Greenberg,C.R., McLeod,D.R., Bernier,F.P., Chudley,A.E., Muller,T.,
            Shboul,M., Logan,C.V., Loucks,C.M., Beaulieu,C.L., Bowie,R.V.,
            Bell,S.M., Adkins,J., Zuniga,F.I., Ross,K.D., Wang,J., Ban,M.R.,
            Becker,C., Nurnberg,P., Douglas,S., Craft,C.M., Akimenko,M.A.,
            Hegele,R.A., Ober,C., Utermann,G., Bolz,H.J., Bulman,D.E.,
            Katsanis,N., Blacque,O.E., Doherty,D., Parboosingh,J.S.,
            Leroux,M.R., Johnson,C.A. and Boycott,K.M.
  TITLE     TMEM237 is mutated in individuals with a Joubert syndrome related
            disorder and expands the role of the TMEM family at the ciliary
            transition zone
  JOURNAL   Am J Hum Genet 89 (6), 713-730 (2011)
   PUBMED   22152675
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Zuniga,F.I. and Craft,C.M.
  TITLE     Deciphering the structure and function of Als2cr4 in the mouse
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 51 (9), 4407-4415 (2010)
   PUBMED   20375344
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_006244975.5.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000009.1  68062910-68063065   c
            157-188             JAXUCZ010000009.1  68060573-68060604   c
            189-199             JAXUCZ010000009.1  68059948-68059958   c
            200-256             JAXUCZ010000009.1  68058422-68058478   c
            257-394             JAXUCZ010000009.1  68052937-68053074   c
            395-512             JAXUCZ010000009.1  68049085-68049202   c
            513-670             JAXUCZ010000009.1  68048174-68048331   c
            671-794             JAXUCZ010000009.1  68044893-68045016   c
            795-986             JAXUCZ010000009.1  68044473-68044664   c
            987-1060            JAXUCZ010000009.1  68043072-68043145   c
            1061-1151           JAXUCZ010000009.1  68041974-68042064   c
            1152-1273           JAXUCZ010000009.1  68034382-68034503   c
            1274-1885           JAXUCZ010000009.1  68030664-68031275   c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1885
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="transmembrane protein 237"
                     /db_xref="GeneID:316412"
                     /db_xref="RGD:1306705"
     exon            1..156
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1335
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 4"
                     /codon_start=1
                     /product="transmembrane protein 237 isoform 1"
                     /protein_id="NP_001424591.1"
                     /db_xref="GeneID:316412"
                     /db_xref="RGD:1306705"
                     /translation="MTSRETVGEPPPLLGTSTYAERPPRALPPVPSAIQDEIPLSHPK
                     KKKSRTKSTPAPASSEGLAEPVVNRRAEGSEPPAAELKEYPEAPVQRKQKKIRPPPEL
                     ETSFTEKPSSPSLLRNENGMDVEPREEVVIPKPRRKAKKMQPAEPQYASELGVEDEDV
                     ITDEQSTLEHHSRFTAPTGVSQPVGKIFVEKSRRFQAADRSELIKTTENVDVSMDMKP
                     SWTTRDVALSVHRAFRMIGLFSHGFLAGCAVWNIVVICVLAGDQFSNVSNLLQQYKPL
                     AYPFQSLLYLLLALSTVSAFDRIDFAKTSVAIRNFLALEPTALASFLYFTALTLSLSQ
                     QMTSDRIYLYEPSVNGSLWPAEVEEPVLMPWVIVNLVVALLVGLAWLFLSYRPGMDLS
                     EELMFFSDVDEYPERGVKASP"
     misc_feature    535..1263
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="Transmembrane protein 237; Region: TMEM237;
                     pfam15383"
                     /db_xref="CDD:464690"
     misc_feature    535..1263
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /note="Transmembrane protein 237; Region: TMEM237;
                     pfam15383"
                     /db_xref="CDD:464690"
     exon            157..188
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            189..199
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            200..256
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            257..394
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..512
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..670
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            671..794
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            795..986
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1060
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1151
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1273
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1885
                     /gene="Tmem237"
                     /gene_synonym="Als2cr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggctgca ggcaaagcgg gagaggaggc tgtttccggt gggagcttga atcctggtct
       61 ggtcaagcgg tgctcatccc cacgcaaatc gtgatgacct cccgggaaac tgtgggtgaa
      121 ccccctccgc tcctggggac gtcgacatac gctgagcgtc ctccgcgagc acttccacct
      181 gtgccaagtg ctatccaaga tgagattcca cttagtcatc ctaagaaaaa gaaatccaga
      241 acaaagagca caccagctcc tgcttcttca gaaggccttg ctgagcccgt tgttaacagg
      301 agggctgagg gcagtgagcc accagctgca gaactcaagg agtacccaga ggctcctgtt
      361 caaaggaaac agaagaagat aagaccacct cctgagttgg agacttcctt cactgaaaag
      421 ccatccagtc cgtctttact acggaatgaa aacggcatgg acgtggagcc tcgtgaggaa
      481 gtggttattc caaaacctcg aaggaaggcg aagaaaatgc agccagcgga accacagtat
      541 gccagcgagc taggggtaga agatgaagac gtaattacgg atgagcagag cactctagaa
      601 caccactcta ggttcaccgc acccaccgga gtcagccagc ctgttggcaa aatatttgtg
      661 gaaaaaagcc ggagatttca ggcggcggac cgttcggagt tgataaagac cacagaaaac
      721 gtagatgtgt caatggacat gaagccatct tggactaccc gcgatgtggc actttccgtg
      781 caccgagctt tcaggatgat cggcctcttc tctcacggct tcttggctgg ctgtgctgtg
      841 tggaatattg ttgtgatctg tgttctcgcg ggagaccagt tctctaatgt ctccaacctt
      901 ctgcagcagt acaagccctt ggcatatccc ttccagagcc ttctttactt gcttttggct
      961 ctaagtacag tttcagcatt tgacaggatc gactttgcta aaacctcagt agcaatccgg
     1021 aactttttgg ccctggagcc aacagcttta gcctctttct tgtattttac tgctctaaca
     1081 ctatctctga gtcagcaaat gacaagtgac agaatctacc tttacgaacc ttctgtcaat
     1141 ggaagcctct ggccagcaga agtggaggaa ccggttctca tgccatgggt catagtgaat
     1201 ctggtggtgg cgcttctggt tggattagcc tggctctttt tgtcttacag gccaggcatg
     1261 gatcttagtg aagagttgat gttcttttct gatgtggacg agtaccccga gagaggagtc
     1321 aaagcgtctc cgtagcgccg gccggctccg tccctgcagt gacggcctgc gttccccact
     1381 cccgttttta agtgtatttt tataagatac atgtatttat aatcgagctt ttgttacata
     1441 atgctgaaat gctactgtag attgtaaatt atatctggtc tttataccaa atattagggt
     1501 ctttattatt ttcaccttag tgacacagga gataatgagc taaaacaaac aaacaaacaa
     1561 acaaaaaaac acagcaggtg atgtgtttgt ttcctgtcct ttcaaatttg caaaattcat
     1621 gattattatt agctaaagag caccaattta gaaaagcctt aacctcagtg ttataaaata
     1681 tacatcaagt ttaaatgtaa atttagtgaa tggggaagat ggaaaaatgt cttcatttta
     1741 tatttttgat gtcttcttat ggaacactgc aggatgtgat ttgttttctc tgaatctggc
     1801 tagtgttata gctcatataa taattatttg ccatttgaat tgaaagatgc tttatagcta
     1861 ataaaacaga aatacctatc tttga
//
LOCUS       NM_001108470            2542 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus myeloid zinc finger 1 (Mzf1), transcript variant
            1, mRNA.
ACCESSION   NM_001108470 XM_001062114 XM_006228116 XM_341789
VERSION     NM_001108470.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Xing,F., Gu,H., Niu,Q., Fan,X., Wang,Z., Yuan,J., Li,Z., Xu,J.T.
            and Zhang,W.
  TITLE     MZF1 in the Dorsal Root Ganglia Contributes to the Development and
            Maintenance of Neuropathic Pain via Regulation of TRPV1
  JOURNAL   Neural Plast 2019, 2782417 (2019)
   PUBMED   31582966
  REMARK    GeneRIF: that MZF1 may contribute to neuropathic pain via
            regulation of TRPV1 expression in dorsal root ganglions
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Li,Z., Gu,X., Sun,L., Wu,S., Liang,L., Cao,J., Lutz,B.M.,
            Bekker,A., Zhang,W. and Tao,Y.X.
  TITLE     Dorsal root ganglion myeloid zinc finger protein 1 contributes to
            neuropathic pain after peripheral nerve trauma
  JOURNAL   Pain 156 (4), 711-721 (2015)
   PUBMED   25630025
  REMARK    GeneRIF: This study demonstrated that MZF1 participated in
            CCI-induced reductions in Kv1.2 mRNA and protein and total Kv
            current and the CCI-induced increase in neuronal excitability
            through MZF1-triggered Kv1.2
            Erratum:[Pain. 2022 Feb 1;163(2):e384. doi:
            10.1097/j.pain.0000000000002563. PMID: 35029603]
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Peterson,F.C., Hayes,P.L., Waltner,J.K., Heisner,A.K., Jensen,D.R.,
            Sander,T.L. and Volkman,B.F.
  TITLE     Structure of the SCAN domain from the tumor suppressor protein MZF1
  JOURNAL   J Mol Biol 363 (1), 137-147 (2006)
   PUBMED   16950398
  REMARK    Erratum:[J Mol Biol. 2007 Feb 9;366(1):346]
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Le Mee,S., Fromigue,O. and Marie,P.J.
  TITLE     Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human
            N-cadherin promoter in osteoblasts
  JOURNAL   Exp Cell Res 302 (1), 129-142 (2005)
   PUBMED   15541732
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Morris,J.F., Rauscher,F.J. 3rd, Davis,B., Klemsz,M., Xu,D.,
            Tenen,D. and Hromas,R.
  TITLE     The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in
            vitro
  JOURNAL   Blood 86 (10), 3640-3647 (1995)
   PUBMED   7579328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_006228116.5, NM_001108470.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1589517.1,
                                           SRR26643298.1501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000001.1  82754747-82754923   c
            178-616             JAXUCZ010000001.1  82752949-82753387   c
            617-800             JAXUCZ010000001.1  82752397-82752580   c
            801-871             JAXUCZ010000001.1  82751925-82751995   c
            872-992             JAXUCZ010000001.1  82751686-82751806   c
            993-2542            JAXUCZ010000001.1  82743531-82745080   c
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2542
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="myeloid zinc finger 1"
                     /db_xref="GeneID:361508"
                     /db_xref="RGD:1308391"
     exon            1..177
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            178..616
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2425
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 98"
                     /codon_start=1
                     /product="myeloid zinc finger 1 isoform 1"
                     /protein_id="NP_001101940.1"
                     /db_xref="GeneID:361508"
                     /db_xref="RGD:1308391"
                     /translation="MKPIVPDSSGRAPPENEPAVVKLEDSDNYDKREDTLWDPGPEAA
                     RLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQ
                     ARVQEQWPGSPEEAAALVDRLRWELDGPRKWVTVQVQGKEVLSEKMEPSSFQPRPQVK
                     LQTPEAGSETTPGATQELPLDLQMKEETELMENPELLESEPLSAAQEAAATLLPKVAQ
                     GHGIALDQTSPHSDTEPDVPPWSEDPMPLWHEEVEGILSPGFTLQMDSITAEPDTVSP
                     HLHVPWDLDMASLSGQMQSPTREGGFAHALVLPSDPGSEQDPACEDPCPSVGPALVAT
                     RWHAPRDRSQGHPSTGTGVMRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR
                     SFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSF
                     RQRSNLLQHQRIHGDPPGPAPPVRSLAGVPEPPGPFPCSECCESFPRRAVLLEHQAVH
                     TGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTG
                     ERPFACTECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEK
                     PYRCSECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLIQHRRIHTGERPY
                     ACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQRIHSTE"
     misc_feature    338..676
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    338..676
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    1289..2368
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1289..2368
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1292..1354
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1292..1354
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1307..1309,1313..1315,1319..1321,1325..1330,
                     1337..1342,1349..1351,1391..1393,1397..1399,1409..1414,
                     1421..1426,1433..1435,1475..1477,1481..1483,1487..1489,
                     1493..1498,1505..1510,1517..1519)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1307..1309,1313..1315,1319..1321,1325..1330,
                     1337..1342,1349..1351,1391..1393,1397..1399,1409..1414,
                     1421..1426,1433..1435,1475..1477,1481..1483,1487..1489,
                     1493..1498,1505..1510,1517..1519)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1376..1438
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1376..1438
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1460..1522
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1460..1522
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1544..1606
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1544..1606
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1679..1741
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1679..1741
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1763..1825
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1763..1825
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1847..1909
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1847..1909
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1862..1864,1868..1870,1874..1876,1880..1885,
                     1892..1897,1904..1906,1946..1948,1952..1954,1964..1969,
                     1976..1981,1988..1990,2030..2032,2036..2038,2042..2044,
                     2048..2053,2060..2065,2072..2074)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1862..1864,1868..1870,1874..1876,1880..1885,
                     1892..1897,1904..1906,1946..1948,1952..1954,1964..1969,
                     1976..1981,1988..1990,2030..2032,2036..2038,2042..2044,
                     2048..2053,2060..2065,2072..2074)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1931..1993
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1931..1993
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2015..2077
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2015..2077
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2099..2161
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2099..2161
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2114..2116,2120..2122,2126..2128,2132..2137,
                     2144..2149,2156..2158,2198..2200,2204..2206,2216..2221,
                     2228..2233,2240..2242,2282..2284,2288..2290,2294..2296,
                     2300..2305,2312..2317,2324..2326)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2114..2116,2120..2122,2126..2128,2132..2137,
                     2144..2149,2156..2158,2198..2200,2204..2206,2216..2221,
                     2228..2233,2240..2242,2282..2284,2288..2290,2294..2296,
                     2300..2305,2312..2317,2324..2326)
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2183..2245
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2183..2245
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2267..2329
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2267..2329
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2351..2413
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2351..2413
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            617..800
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            801..871
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            872..992
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
     exon            993..2542
                     /gene="Mzf1"
                     /gene_synonym="Zfp98"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgggggg catgcgcggt gtggaaggcg gtgctaccat ctgttgcccc ccgagaggat
       61 tgtgcacgtc gacggggccc tgacgcctgg attcgagacg gggagtgtgg gaagagacgg
      121 ccaggagtgc gacctgatta ttgcgaccag cgcaatccct tggggacggg aagaagggga
      181 cagacactgg cctcaaagac ctgatctggt tctcctgatg aaacccattg tgccagactc
      241 ctcaggccgt gcacccccag aaaatgagcc tgctgtggtg aagctggagg actctgacaa
      301 ctacgataag agagaagata cactgtggga cccaggccct gaagctgcac gtctacgctt
      361 ccggtgcttt cggtatgagg aggcaatagg tcctcaggaa gccctggctc agctccgaga
      421 actgtgtcac cagtggctac gtccagaggt acattccaag gaacagatcc tggaactttt
      481 ggtgctggag cagttcctag gtgcactgcc ttctgagatc caggcccgtg tgcaagagca
      541 gtggccaggc agccctgaag aggctgctgc cttggttgac agacttcgat gggagcttga
      601 tggacctcgg aaatgggtca cggtccaggt acagggcaag gaggtcctat cagagaagat
      661 ggaaccttcc agcttccagc ctagacctca agtcaagctt cagactccag aggctgggtc
      721 tgagactacc ccaggggcca cgcaggaatt gccgctggac ctacaaatga aagaggagac
      781 agagttgatg gagaatccag agctcctgga gtctgagcct ctttctgctg ctcaagaggc
      841 tgcagccact ctcctaccta aggtggccca gggccatggg atagcactgg accagacctc
      901 tcctcacagc gacactgaac ctgatgtgcc cccatggagc gaggacccta tgcccctgtg
      961 gcatgaggaa gtagaaggca tcttgtcgcc agggttcacg ctgcagatgg acagcatcac
     1021 agcagagcca gatacggtga gcccccacct ccatgtcccc tgggatctgg acatggctag
     1081 cctctctgga cagatgcagt cccctaccag agaaggtggc tttgcccatg ccctcgtact
     1141 ccccagcgat ccaggaagtg aacaggaccc tgcctgtgag gatccctgcc ccagtgtggg
     1201 cccagcactg gtggcgactc gctggcatgc cccaagggac cggagccagg gccaccctag
     1261 cacagggact ggagtgatgc gaggcggccg ctgcgacgtg tgtggcaagg tattcagcca
     1321 gcgaagcaat ctgctgcggc accagaagat ccacacaggc gagagaccgt tcgtgtgtgg
     1381 cgagtgtggc cgaagtttca gccgcagctc tcacctgctg cgccaccaac tcacgcatac
     1441 tgaggaacgg cctttcgtgt gccgcgactg tggccaaggc ttcgtgcgca gcgcccgcct
     1501 ggaggagcat cggcgcgtgc acacgggcga gcagccgttc cgctgcgcag agtgcggcca
     1561 gagctttcgg cagcgctcca acctactgca gcaccagcgc atccacggtg acccgccagg
     1621 tccggcgccg cccgtccggt ccctcgctgg agtgcccgag cctccgggcc ccttcccttg
     1681 cagcgagtgc tgcgagagct tcccacgacg cgcagtactg ctcgagcacc aagcggtgca
     1741 caccggagac aagtccttcg gatgcgtgga gtgcggcgag cgcttcggcc gccgctcggt
     1801 gctgctgcag catcggcgcg tgcatagcgg cgaacgacct ttcgcatgtg ccgagtgcgg
     1861 tcaaagcttc cggcagcgct ccaacctcac ccagcaccgg cgcatccaca ccggcgagcg
     1921 gcccttcgcc tgcacagaat gtggcaaggc cttccgccag cggcccactc tcacgcagca
     1981 cctgcgtgtg cacaccggtg agaagccctt cgcctgcccc gagtgcggcc agcgcttcag
     2041 ccagcgactc aagctcacac gccaccaaag gacccatacg ggcgagaagc cctaccgctg
     2101 cagtgaatgc ggcctcggtt tcacgcaggt gtctcggctc accgagcacc agcgcatcca
     2161 cacaggtgag cggcctttcg cctgtcccga atgtggccag agcttccggc agcacgccaa
     2221 cctcatccag caccggcgca tccatacagg cgagcggccc tacgcgtgtc ccgagtgtgg
     2281 caaggccttc cgccagcggc ccacgctcac gcagcacctg cgcacccacc ggcgcgaaaa
     2341 gcccttcgcc tgccaggact gtggccgccg ctttcaccag agcaccaagc tcatccaaca
     2401 tcaacgcatc cacagcactg agtagctgta cagcactgag taggtcaaaa cacctcatta
     2461 ggttgttgtg aggctgccat cttccaacag gcccaagtag agccttcagt aggtgctcaa
     2521 taaatagata atgcttcccc aa
//
LOCUS       NM_001191637            4167 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 16, member 12 (Slc16a12),
            transcript variant 1, mRNA.
ACCESSION   NM_001191637 XM_017589301 XM_220057
VERSION     NM_001191637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4167)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Contribution of monocarboxylate transporter 12 to blood supply of
            creatine on the sinusoidal membrane of the hepatocytes
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (2), G113-G122 (2021)
   PUBMED   34075817
REFERENCE   2  (bases 1 to 4167)
  AUTHORS   Verouti,S.N., Lambert,D., Mathis,D., Pathare,G., Escher,G., Vogt,B.
            and Fuster,D.G.
  TITLE     Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney
  JOURNAL   Am J Physiol Renal Physiol 320 (3), F351-F358 (2021)
   PUBMED   33459166
  REMARK    GeneRIF: Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney.
REFERENCE   3  (bases 1 to 4167)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Monocarboxylate transporter 12 as a guanidinoacetate efflux
            transporter in renal proximal tubular epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (11), 183434 (2020)
   PUBMED   32781157
  REMARK    GeneRIF: Monocarboxylate transporter 12 as a guanidinoacetate
            efflux transporter in renal proximal tubular epithelial cells.
REFERENCE   4  (bases 1 to 4167)
  AUTHORS   Abplanalp,J., Laczko,E., Philp,N.J., Neidhardt,J., Zuercher,J.,
            Braun,P., Schorderet,D.F., Munier,F.L., Verrey,F., Berger,W.,
            Camargo,S.M. and Kloeckener-Gruissem,B.
  TITLE     The cataract and glucosuria associated monocarboxylate transporter
            MCT12 is a new creatine transporter
  JOURNAL   Hum Mol Genet 22 (16), 3218-3226 (2013)
   PUBMED   23578822
REFERENCE   5  (bases 1 to 4167)
  AUTHORS   Castorino,J.J., Gallagher-Colombo,S.M., Levin,A.V.,
            Fitzgerald,P.G., Polishook,J., Kloeckener-Gruissem,B., Ostertag,E.
            and Philp,N.J.
  TITLE     Juvenile cataract-associated mutation of solute carrier SLC16A12
            impairs trafficking of the protein to the plasma membrane
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6774-6784 (2011)
   PUBMED   21778275
  REMARK    GeneRIF: a model whereby the SLC16A12 (c.643C>T) mutation causes
            juvenile cataract by a defect in protein trafficking rather than by
            haploinsufficiency.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_017589301.3, NM_001191637.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.4706.1,
                                           SRR26643288.6974.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000001.1  241674683-241674923 c
            242-489             JAXUCZ010000001.1  241621607-241621854 c
            490-593             JAXUCZ010000001.1  241608971-241609074 c
            594-737             JAXUCZ010000001.1  241605846-241605989 c
            738-1317            JAXUCZ010000001.1  241603636-241604215 c
            1318-1577           JAXUCZ010000001.1  241601272-241601531 c
            1578-4167           JAXUCZ010000001.1  241597154-241599743 c
FEATURES             Location/Qualifiers
     source          1..4167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..4167
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16, member 12"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
     exon            1..241
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            242..489
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    329..331
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="upstream in-frame stop codon"
     CDS             380..1840
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 12; solute carrier family 16, member
                     12 (monocarboxylic acid transporter 12)"
                     /codon_start=1
                     /product="monocarboxylate transporter 12"
                     /protein_id="NP_001178566.1"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
                     /translation="MTKITRVGSASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFV
                     EFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGLILG
                     SFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKAFAYGIAMSGSGIGTFIL
                     APVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDPSGPEKSHDRDAQRED
                     CKQASPYSPLTKEWTETRLCCSLQQGYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP
                     YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCY
                     LCLPMLQSFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPY
                     LVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFAKIAKRMKRTQVPFLVKDSDP
                     KLHLWTNGSVAYSIAKELDQKDEESLAKARTGCNLT"
     misc_feature    407..469
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    431..1672
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="Monocarboxylate transporter 12 of the of the Major
                     Facilitator Superfamily of transporters; Region:
                     MFS_MCT12; cd17424"
                     /db_xref="CDD:340982"
     misc_feature    431..1672
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="Monocarboxylate transporter 12 of the of the Major
                     Facilitator Superfamily of transporters; Region:
                     MFS_MCT12; cd17424"
                     /db_xref="CDD:340982"
     misc_feature    order(464..469,476..481,488..490,593..595,746..751,
                     755..763,770..772,827..829,836..841,848..850,1157..1159,
                     1166..1171,1178..1186,1193..1195,1274..1276,1286..1288,
                     1445..1450,1460..1462,1472..1474,1520..1522,1529..1534,
                     1541..1546,1553..1555)
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340982"
     misc_feature    order(464..469,476..481,488..490,593..595,746..751,
                     755..763,770..772,827..829,836..841,848..850,1157..1159,
                     1166..1171,1178..1186,1193..1195,1274..1276,1286..1288,
                     1445..1450,1460..1462,1472..1474,1520..1522,1529..1534,
                     1541..1546,1553..1555)
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340982"
     misc_feature    551..613
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    635..697
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    722..784
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    821..883
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    908..970
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    980..1042
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1136..1198
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1244..1306
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1337..1399
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1436..1498
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1526..1588
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     misc_feature    1607..1669
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A734.1);
                     transmembrane region"
     exon            490..593
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            594..737
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1317
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1577
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..4167
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcagagt caccctcggg gctggcgtca ctgagagcct tggttctccg gggcggggcg
       61 gtgggatctc ctcagtgaca gtgtccggcg ggctctgcct gtggccccgg cccctacggc
      121 gcctccgccc cgtgcgcacc ccgcccctcg gccggaccgg actccagggg ccgtgggaag
      181 gggccgccgt gcagggggca tgtgggctca ccgtcgccag ctctgcagct gtccccgcga
      241 gatgggcagt aatccctgtg ccaggtagca tcctgaacca actttgagga tcaacaggaa
      301 gttgctgggt agcaaccact gaggatccta acttactgct gcagtgacct ggaaagagaa
      361 gaaaaccaaa attgcaacca tgacgaagat aactagagtt ggttccgcat cccctccaga
      421 tggaggctgg ggatggatga ttgtggccgg ctgctttctt gttaccatct gcacccgggc
      481 agtcaccagg tgtatctcca tattttttgt ggagtttcag acgtactttg ctcaggatta
      541 ttcccaaaca gcatggatcc attccattgt agactgcatg acaatgctct gtgctccgct
      601 tgggagtgtt gtcagtaacc aattatcctg tcaagcgggg atcatgctgg gtggcttgct
      661 ggcatctact ggtctcatcc tgggctcatt tgccaccagt ttgaagcacc tctacctcag
      721 tctgggagtt ctcacaggtc ttggatttgc actttgttac tccccagcaa ttgccatggt
      781 gggcaagtac ttcagcaggc ggaaagcctt cgcttacggg attgccatgt caggcagtgg
      841 cattggtacc ttcatcctgg cccctgtggt tcagctcctc attgaacagt tctcctggcg
      901 aggagcactg ctcattcttg gtgggttcgt tctgaatctc tgcgtctgcg gcgcgctgat
      961 gcgtccaatt acccttaaag aggacccgtc aggcccagag aagagtcacg accgtgacgc
     1021 tcagagagaa gactgtaagc aggcatctcc ctattcacct ttgaccaaag aatggacaga
     1081 gacccgtctt tgctgctctt tgcagcaagg atacggcttt ttactgatgt cagacttcgt
     1141 cgtgctggct gtctctgttc tgttcatggc ctacggctgc agccctctct ttgtgtacct
     1201 ggtgccttat gctttgagtg tcggagtgag tcaccatcaa gctgctttcc tcatgtccat
     1261 cctcggagtg attgatattg tcggcaacat cacgtttggc tggctaactg acagaaggtg
     1321 tctgaagaat taccgatatg tttgctacct ctttgctgtg gcactagatg ggctgtgcta
     1381 tctgtgtctc ccaatgcttc aaagcttccc ccttcttgtg cctttctctt gtacctttgg
     1441 ctacttcgac ggagcctacg ttaccttgat cccagtagtg actgcagaga tagtagggac
     1501 cacctctttg tcatcagcac ttggcgtggt ctacttcctc catgcagtgc catacttggt
     1561 gagcccaccc attgcaggat ggctggtgga cacgacgggc agctatactg cagccttcct
     1621 tctttgtgga tttgccatga tatttagttc catcctgctt ggctttgcca aaattgcaaa
     1681 aagaatgaaa agaacacagg tgcccttcct ggtcaaagac tcagatccca agctgcatct
     1741 gtggaccaat ggatcagtgg cctactctat agcgaaggag ttagatcaga aagatgagga
     1801 atccctggct aaagctagga ctggttgcaa tctcacatga cctgtgtggc cttgtcctgg
     1861 gaatctgcaa ggctggtgga taccaggcca ccaggttgtt cacagtctgg aaatatttta
     1921 ttttgacaga gtatcacctc ccaagtaaat tattaatact gttttgttaa catatttata
     1981 tggggacaat aatgagcaac aaagaaatct ggagttagcc tggagttttc tcattcagga
     2041 tttgtactca ctacaaactt agctctggga gaagggcagg acacagttga cagggtcagt
     2101 tgtatttcag gacaactcta agcagaggcc actgtgaaga gttttcataa aatctgcccc
     2161 accccctcat tctgaacaga agcagtggtg gttgtgctgg cagtggggat gcagaggtga
     2221 cttgagaaca gagcgcctca atgtttagag tggcaaagaa attcttgaga ctctttgaaa
     2281 ggcaatgata aattaatgta caacagacac tctcttatcc atttcccagc caaccagtaa
     2341 ccagtgcctc ttccaatggg tagccatcac tttgagagac ccaacagtca tcaaacacta
     2401 tggctggaac agactttaga gagtggcttg tggtaatact ttatttgtaa ctgtcttgtt
     2461 gaaacagaag ctcttttctt cagaccgtcc ccccgacccc cgacactcac cctgtcatta
     2521 ctgcatactg actctaaatg taacacaact cgttcaatgt tgggacaact gctacatctt
     2581 tcctgaagtg attgtaatac cccaggaatc ctcagctttt tcttctcttt gaaaaaaaaa
     2641 ggttctaatt tgaactttag gcacattcct tttaggaata gaaaaatgtt gacagtattc
     2701 cagttgagca gtaattgaat tcctgagtca gcagtcgtta gagtcatcat tatccaaaag
     2761 aggggttggg ggttttctta tcatacaaat gttctaaaga tggcctttgg agttcaccat
     2821 atcccttgtt ggatcatagt tataaatctg actcattggc ttagaagtgt ctgctccatc
     2881 gcttctcggc cttttggcta agatcaagtg tagaagtgtc tgctccttct cggaggccag
     2941 actttgcagg gacatgaaat cctttctgaa ttttcatatc agagaaaagt acaaaaaaga
     3001 agaaaggtgg ggccacatct tatccccagc tgttttaata tccacacaat taagagtcct
     3061 gaatccccaa tcaggtacca ttttcaaaga aggacaagtt atataataaa agggggatgt
     3121 tttcaattgt tcaagagttt aaatgcaagt cacaaggaaa cgttgtgaac tcaatgacca
     3181 tttaacctac tgtccccaag aagcctcaga gtggcttttg ccagacatgg tgctgggaga
     3241 aataacaaag cgttgaggga tggctgaggt gactgagttc tcacttgaac tgagtatgtt
     3301 tgtgttgcta tactgctttc ataatgagat actggcttga ttcgatggag agatcggcac
     3361 tactcacatt gtagtttttc acagaaaaat gtgagtgtcc tgtctttact cagtctggga
     3421 ctttagtttt gaatccattc actgtgttat ttgcaatttt aaaaatactt tgaggagatc
     3481 tgtaaaaatt caaagtcaaa attgaatact caaaatatat tcaagatgaa atacttgttt
     3541 tggaatagca ctttacccta aatgtcattt ttaatcataa aaatgctttt tcttaaaaaa
     3601 gtaagtactc ttatttgtat gtttttaaag aattgattgt aaattttgtt tgtgtgattc
     3661 tataatatag tttctctatt gtgtttataa aaaactagga taatgatcaa aggttttaaa
     3721 cttatataaa acattttaga tcttttgact ttatccgtgc aataaatttg cattctaact
     3781 ttcttgggaa aacatttttg aagaaccagt aagaaaaact gtagatctta cagtttacag
     3841 tttggtcacc tgcacaacat gttactaaaa cattttctcc atgtatttaa acagttggtt
     3901 ccaaagctaa ggaattcata ggaatggggc attttgtgga gtcaagaata aaccagtaga
     3961 gaaattattt tatgccttaa atatttgttc acccaactgt aggttcacct ttgtaactaa
     4021 gtaggaaaac aagacagaat ctaaattttc aatgtgctat tttttctgtt gcttaaatta
     4081 gaattctact aatgaatccg atgtgtaggc taatgttttc ctagttcaaa ggcaaaataa
     4141 aatggattta tactcacatg tttcaaa
//
LOCUS       NM_001108469             964 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus CDC42 effector protein 5 (Cdc42ep5), transcript
            variant 1, mRNA.
ACCESSION   NM_001108469 XM_001070494 XM_008758944 XM_341784
VERSION     NM_001108469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_008758944.4, NM_001108469.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI295807.1, SRR22582416.796775.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               JAXUCZ010000001.1  79108335-79108595
            262-368             JAXUCZ010000001.1  79108872-79108978
            369-964             JAXUCZ010000001.1  79109955-79110550
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..964
                     /gene="Cdc42ep5"
                     /note="CDC42 effector protein 5"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
     exon            1..261
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     exon            262..368
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    336..338
                     /gene="Cdc42ep5"
                     /note="upstream in-frame stop codon"
     exon            369..964
                     /gene="Cdc42ep5"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..830
                     /gene="Cdc42ep5"
                     /note="isoform 1 is encoded by transcript variant 1; CDC42
                     effector protein (Rho GTPase binding) 5"
                     /codon_start=1
                     /product="cdc42 effector protein 5 isoform 1"
                     /protein_id="NP_001101939.1"
                     /db_xref="GeneID:361505"
                     /db_xref="RGD:1308382"
                     /translation="MALLKQVGPAQPKKRLERGALSISAPLGDFRHTLHVGSSGDAFG
                     DTSFLNRHGGGPPPEAGAPPVVAPHSVPPPAVPQASVPGLRVPSPADPLLSFHLDLGP
                     SMLDAVLGVMDAERGETTATKPSGDALTGMQHPNAHCCSNADFQLDDVIGL"
     misc_feature    435..>518
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    435..>518
                     /gene="Cdc42ep5"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; Region: CRIB; cl00113"
                     /db_xref="CDD:412170"
     misc_feature    <576..707
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
     misc_feature    <576..707
                     /gene="Cdc42ep5"
                     /note="Cdc42 effector; Region: BORG_CEP; pfam14957"
                     /db_xref="CDD:464403"
ORIGIN      
        1 tggcttccac tatgctcagt cctgatctcc acctaccccc acaatccctt caaagggcct
       61 ttaggtttac taccaacaag gctttctagt cctttaaatc ctagaggcaa attttgaggg
      121 aataaggaag gttgggaggg gcctatggct taaccctctc agtctgggac aagaggccaa
      181 ctctcactgg gcgttgactc ggtgttgggt tgggaggctg ctatggcccc cgagaggggc
      241 tgaagcttat tcccggtgca ggtgagatcc cgccgggaga aagaaggaaa aaggcgtcag
      301 agaggtagcc tccaaggcca ggagagaccc cagtttaagc cggattacaa ttcagtctgg
      361 accacgagat ggcgttgttg aagcaggtgg gccctgcaca gccaaagaag cgactggagc
      421 gtggagcact ctctatctca gcaccccttg gagacttcag gcacacattg cacgtgggaa
      481 gcagtggcga tgccttcgga gacacctcat tcctgaatag gcacgggggt ggtccacctc
      541 cggaggctgg agccccacca gttgtggccc cacattctgt ccctccacct gcagttccac
      601 aggcctctgt gcctggtctc cgagttcctt cacctgcaga cccgctactg tccttccacc
      661 tggacctggg cccctctatg ctggacgcag tgttaggcgt catggacgcg gagcgcggcg
      721 agacgacggc caccaagccc agtggggatg ccctcactgg aatgcagcat cccaatgccc
      781 actgctgctc caatgctgac ttccagctgg atgatgtcat tggtctgtag tatcttgatt
      841 cccgcaactc ctccctccct gcactccact tttgtacaca taaatagccg agttttacgc
      901 gggaaggggt gcagaagcag gacagtggtg gggtgccacc aactaaaagt caaatctgtc
      961 ctca
//
LOCUS       NM_001109006            2052 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 23, member 3 (Slc23a3),
            mRNA.
ACCESSION   NM_001109006 XM_001060290 XM_346061
VERSION     NM_001109006.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474004.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_346061.3, XM_001060290.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680413,
                              SAMN06680416 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2052
                     /gene="Slc23a3"
                     /note="solute carrier family 23, member 3"
                     /db_xref="GeneID:367298"
                     /db_xref="RGD:1307402"
     exon            1..203
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1868
                     /gene="Slc23a3"
                     /note="solute carrier family 23 (nucleobase transporters),
                     member 3"
                     /codon_start=1
                     /product="solute carrier family 23 member 3"
                     /protein_id="NP_001102476.1"
                     /db_xref="GeneID:367298"
                     /db_xref="RGD:1307402"
                     /translation="MSRSPPHPIPLLSVGSQDTPAPRPPLLPPLQDPSSRSWASWCGP
                     STWGLSCLLALQHFLVLTSLLWASHLLLLHSLPPGGLSYPPAQLLASSFFSCGMSTVL
                     QTWMGSRLPLIQAPSLEFLIPALVLTNQKLPLMTKTPGNASLSLRLCSLTRSCHGPEL
                     WNTSLREVSGAVVMSGLLQGTMGLLGVPGRVFPYCGPLVLAPSLVVAGLSAHKEVAQF
                     CSAHWGLALLLILLMVVCSQHLGSCQVPLCSWRPASTSSTHIYIPIFRLLSVLAPVAC
                     VWLISACLGLSVIPLQLSEPSDAPWFWLPHPGEWEWPLLTPKALAAGISMALAASTSS
                     LGCYALCGQLLHLSPPPPHACSRGLSLEGLGSVLAGLLGSPLGTASSFPNVGTVSLFQ
                     TGSRRVAHLVGLFCMGLGLSPRLAQLFTNIPLPVLGGVLGVTQAVVLSAGFSSFHLAD
                     IDSGRNVFIVGFSIFMALLLPRWLREAPILLNTGWSPMDMFLRSLLAEPIFLAGLLGF
                     LLENTISGTRIERGLGQALPTSFTAQETQMLQKSRKKAAQEYGLPLSIKNLCSCIPQP
                     LRCLCPMPEDSGDEGGSSKTGETADLLPNSGESSSPDGREGFRS"
     misc_feature    270..1463
                     /gene="Slc23a3"
                     /note="Permease family; Region: Xan_ur_permease;
                     pfam00860"
                     /db_xref="CDD:395690"
     misc_feature    270..1463
                     /gene="Slc23a3"
                     /note="Permease family; Region: Xan_ur_permease;
                     pfam00860"
                     /db_xref="CDD:395690"
     exon            204..361
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..459
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..536
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..718
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..842
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..957
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1211
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1317
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1485
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1581
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..2052
                     /gene="Slc23a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaggcagc caagacgcaa tcaagtcagg gcagcatgag cagatcacct ccccatccca
       61 ttccacttct atctgtgggc tcccaggata cccctgctcc ccgtccacca ctgctacccc
      121 ctctccagga tccctcctcc cgctcttggg cctcttggtg tgggccttcc acctgggggc
      181 tcagctgtct tctggctcta cagcatttcc tggtcttgac atctctgctc tgggcctccc
      241 acctgctgct gcttcacagt ctccccccag gagggctctc atacccacct gctcagctcc
      301 tggcttccag tttcttctca tgtggcatgt ctacggtcct gcagacttgg atgggcagca
      361 ggctgcctct aatccaggct ccgtccctag agtttcttat ccctgcactg gtgctgacaa
      421 accagaagct acctctgatg accaagacac ctggaaatgc ctccctctcc ctacgcctgt
      481 gtagtttgac aagaagttgc catggcccgg agctctggaa cacatctctc cgagaggtgt
      541 cgggggcagt ggtgatgtcc gggctgctgc agggcactat gggacttcta ggggtgcctg
      601 gtcgtgtgtt tccctactgt gggccactgg tgctggctcc cagcctggtt gtggcagggc
      661 tctctgccca caaggaagtg gcccagttct gttctgctca ctggggcctg gccttgctgc
      721 tcatcctgct catggtggta tgctcccagc acttggggtc ctgccaggta cccctttgct
      781 cctggaggcc agcttcaacc tcttcaactc acatttatat tcctatcttc cgactccttt
      841 cggtgcttgc ccctgtggcc tgtgtgtggc tcatctctgc ctgtctgggt ctgagtgtta
      901 tccccttgca gctgtctgag ccctccgatg caccgtggtt ttggctgcct cacccaggtg
      961 agtgggaatg gcccttgctg acacccaagg ccctggctgc agggatctcc atggctttgg
     1021 cagcctccac cagctccttg ggttgctatg ccctgtgtgg ccagctgctg catttgtctc
     1081 ctccaccacc acatgcctgt agtcgagggc tgagcctgga ggggctgggc agtgtgctgg
     1141 cagggctgct ggggagtccc ctgggcactg catccagctt ccccaatgta ggcacagtga
     1201 gtcttttcca gactggttct cggagagtgg cccacctagt gggactgttc tgcatggggc
     1261 ttggactctc cccaaggctg gctcagttat ttaccaacat cccactgcct gtgcttggtg
     1321 gggtactggg agtgacccag gctgtagttc tgtctgctgg attctccagc ttccacctgg
     1381 ctgacattga ctctggacga aacgtcttca ttgtgggctt ctccatcttc atggctttgc
     1441 ttttgccaag gtggctccgg gaagctccaa tcctccttaa cacaggctgg agccccatgg
     1501 atatgtttct gcgttctttg ctggcagaac ccattttcct agctggtcta ttgggctttc
     1561 tcctagaaaa cactatatct ggtacacgga ttgagagagg cttaggtcag gccctgccaa
     1621 cttctttcac tgcccaagaa acgcaaatgc ttcagaagtc caggaagaaa gccgctcaag
     1681 agtatgggct tcctttgtct atcaaaaacc tgtgttcctg tatcccacag cctctccgtt
     1741 gtctctgtcc aatgcctgaa gactctgggg atgaaggagg atcctctaaa acaggagaga
     1801 cagccgactt gttgcctaac tcaggggagt caagctctcc ggatggcaga gaagggttta
     1861 ggtcctagta attaccaaaa ccaccatttt tgtcttagtt tagcagtaac tcccaccttg
     1921 ctggagtctt gcccccaagg cccgctagta ggatgggctt tctttcctcc tcttaataat
     1981 tagacttgag tgttcaggag caggggtatg gtttagtagg tcagaagtga ataaattaga
     2041 tttttgcctg ta
//
LOCUS       NM_001100690            6443 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus myosin heavy chain 14 (Myh14), transcript variant
            1, mRNA.
ACCESSION   NM_001100690 XM_001080622 XM_218617
VERSION     NM_001100690.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6443)
  AUTHORS   Billington,N., Wang,A., Mao,J., Adelstein,R.S. and Sellers,J.R.
  TITLE     Characterization of three full-length human nonmuscle myosin II
            paralogs
  JOURNAL   J Biol Chem 288 (46), 33398-33410 (2013)
   PUBMED   24072716
REFERENCE   2  (bases 1 to 6443)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   3  (bases 1 to 6443)
  AUTHORS   Choi,B.O., Kang,S.H., Hyun,Y.S., Kanwal,S., Park,S.W., Koo,H.,
            Kim,S.B., Choi,Y.C., Yoo,J.H., Kim,J.W., Park,K.D., Choi,K.G.,
            Kim,S.J., Zuchner,S. and Chung,K.W.
  TITLE     A complex phenotype of peripheral neuropathy, myopathy, hoarseness,
            and hearing loss is linked to an autosomal dominant mutation in
            MYH14
  JOURNAL   Hum Mutat 32 (6), 669-677 (2011)
   PUBMED   21480433
REFERENCE   4  (bases 1 to 6443)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 6443)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 6443)
  AUTHORS   Kim,K.Y., Kovacs,M., Kawamoto,S., Sellers,J.R. and Adelstein,R.S.
  TITLE     Disease-associated mutations and alternative splicing alter the
            enzymatic and motile activity of nonmuscle myosins II-B and II-C
  JOURNAL   J Biol Chem 280 (24), 22769-22775 (2005)
   PUBMED   15845534
REFERENCE   7  (bases 1 to 6443)
  AUTHORS   Turney,S.G. and Bridgman,P.C.
  TITLE     Laminin stimulates and guides axonal outgrowth via growth cone
            myosin II activity
  JOURNAL   Nat Neurosci 8 (6), 717-719 (2005)
   PUBMED   15880105
REFERENCE   8  (bases 1 to 6443)
  AUTHORS   Bao,J., Jana,S.S. and Adelstein,R.S.
  TITLE     Vertebrate nonmuscle myosin II isoforms rescue small interfering
            RNA-induced defects in COS-7 cell cytokinesis
  JOURNAL   J Biol Chem 280 (20), 19594-19599 (2005)
   PUBMED   15774463
  REMARK    Erratum:[J Biol Chem. 2006 Apr 14;281(15):10652]
REFERENCE   9  (bases 1 to 6443)
  AUTHORS   Donaudy,F., Snoeckx,R., Pfister,M., Zenner,H.P., Blin,N., Di
            Stazio,M., Ferrara,A., Lanzara,C., Ficarella,R., Declau,F.,
            Pusch,C.M., Nurnberg,P., Melchionda,S., Zelante,L., Ballana,E.,
            Estivill,X., Van Camp,G., Gasparini,P. and Savoia,A.
  TITLE     Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and
            mutated in patients affected by autosomal dominant hearing
            impairment (DFNA4)
  JOURNAL   Am J Hum Genet 74 (4), 770-776 (2004)
   PUBMED   15015131
REFERENCE   10 (bases 1 to 6443)
  AUTHORS   Golomb,E., Ma,X., Jana,S.S., Preston,Y.A., Kawamoto,S.,
            Shoham,N.G., Goldin,E., Conti,M.A., Sellers,J.R. and Adelstein,R.S.
  TITLE     Identification and characterization of nonmuscle myosin II-C, a new
            member of the myosin II family
  JOURNAL   J Biol Chem 279 (4), 2800-2808 (2004)
   PUBMED   14594953
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 12, 2007 this sequence version replaced
            XM_218617.4, XM_001080622.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2273.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000001.1  104295307-104295344 c
            39-434              JAXUCZ010000001.1  104289705-104290100 c
            435-591             JAXUCZ010000001.1  104284583-104284739 c
            592-619             JAXUCZ010000001.1  104282021-104282048 c
            620-722             JAXUCZ010000001.1  104281725-104281827 c
            723-746             JAXUCZ010000001.1  104281185-104281208 c
            747-839             JAXUCZ010000001.1  104279177-104279269 c
            840-903             JAXUCZ010000001.1  104278794-104278857 c
            904-1002            JAXUCZ010000001.1  104277494-104277592 c
            1003-1143           JAXUCZ010000001.1  104276344-104276484 c
            1144-1239           JAXUCZ010000001.1  104269048-104269143 c
            1240-1358           JAXUCZ010000001.1  104266200-104266318 c
            1359-1511           JAXUCZ010000001.1  104264350-104264502 c
            1512-1685           JAXUCZ010000001.1  104264084-104264257 c
            1686-1859           JAXUCZ010000001.1  104263419-104263592 c
            1860-1974           JAXUCZ010000001.1  104262885-104262999 c
            1975-2162           JAXUCZ010000001.1  104258734-104258921 c
            2163-2284           JAXUCZ010000001.1  104257865-104257986 c
            2285-2354           JAXUCZ010000001.1  104257345-104257414 c
            2355-2515           JAXUCZ010000001.1  104256789-104256949 c
            2516-2624           JAXUCZ010000001.1  104256018-104256126 c
            2625-2756           JAXUCZ010000001.1  104255157-104255288 c
            2757-2963           JAXUCZ010000001.1  104254399-104254605 c
            2964-3101           JAXUCZ010000001.1  104253811-104253948 c
            3102-3225           JAXUCZ010000001.1  104253374-104253497 c
            3226-3397           JAXUCZ010000001.1  104253051-104253222 c
            3398-3610           JAXUCZ010000001.1  104251920-104252132 c
            3611-3755           JAXUCZ010000001.1  104250259-104250403 c
            3756-3962           JAXUCZ010000001.1  104249888-104250094 c
            3963-4067           JAXUCZ010000001.1  104249228-104249332 c
            4068-4220           JAXUCZ010000001.1  104248994-104249146 c
            4221-4469           JAXUCZ010000001.1  104247889-104248137 c
            4470-4682           JAXUCZ010000001.1  104246686-104246898 c
            4683-4895           JAXUCZ010000001.1  104242891-104243103 c
            4896-5057           JAXUCZ010000001.1  104242094-104242255 c
            5058-5186           JAXUCZ010000001.1  104241139-104241267 c
            5187-5275           JAXUCZ010000001.1  104240531-104240619 c
            5276-5399           JAXUCZ010000001.1  104240317-104240440 c
            5400-5608           JAXUCZ010000001.1  104238455-104238663 c
            5609-5717           JAXUCZ010000001.1  104235388-104235496 c
            5718-5890           JAXUCZ010000001.1  104233615-104233787 c
            5891-6443           JAXUCZ010000001.1  104232778-104233330 c
FEATURES             Location/Qualifiers
     source          1..6443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6443
                     /gene="Myh14"
                     /note="myosin heavy chain 14"
                     /db_xref="GeneID:308572"
                     /db_xref="RGD:1306821"
     exon            1..38
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            39..434
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..6044
                     /gene="Myh14"
                     /EC_number="5.6.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin, heavy polypeptide 14; myosin-14; myosin, heavy
                     chain 14, non-muscle"
                     /codon_start=1
                     /product="myosin-14 isoform 1"
                     /protein_id="NP_001094160.1"
                     /db_xref="GeneID:308572"
                     /db_xref="RGD:1306821"
                     /translation="MATVTLSVPGRKVASRPGPVPEAAQPFLFAPRTPNVGGPGGPQV
                     EWTARRMVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSK
                     AEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRG
                     KKRHEVPPHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSP
                     KGRKEPGVPASVSTMSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDI
                     AGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFL
                     TNGPSSSPGQERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQ
                     ATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKA
                     TYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQ
                     LFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPK
                     ATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPLND
                     NVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESL
                     SRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRI
                     LFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQ
                     LEEERDLKVTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWW
                     RLFIKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLA
                     EQLRAEAELCSEAEETRARLAARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQH
                     IQELETHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERRLLEERLA
                     EFSSQAAEEEEKVKSLNKLRVKYEATIADMEDRLKKEEKGRQELEKLKRRLDGESSEL
                     QEQMMEQKQRAEELLIQLGRKEEELQSALVRAEEEGGARAQLLKSLREAQAGLAEAQE
                     DLEAERVARAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL
                     EEEARTHEVAMQELRQRHSQALVELTEQLEQARRGKSVWEKTRLSLEAEVSELKTELS
                     SLQTSRQEGEQKRRRLESQLQEVQGRSSDSERARAEAAEKLQRAQVELESVSTALSEA
                     ESKAIRLSKELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVV
                     ARERAGRELQTTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLAQRLAEKTEAV
                     ERLERARRRLQQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRER
                     VEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKNVHELE
                     RARRVAEQAASDLRTQVTELEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEE
                     RRRQLAKQLRDAEVERDEERKQRALAMAARKKLELELEELKAQTSAAGQGKEEAVKQL
                     KKMQAQMKELWREVEETRSSREEMFTLSRESEKRLKGLEAEVLRLQEELAASDRARRQ
                     AQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKLV
                     LQVETLTTELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKMLIAALES
                     KLAQAEEQLEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKSNLRL
                     KQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTT
                     RTVRQVFRLEEGVASDEEEAEGAEPGSAPTQEPEAPPPAAPQ"
     misc_feature    384..2417
                     /gene="Myh14"
                     /note="class II myosin heavy chain 14 motor domain;
                     Region: MYSc_Myh14_mammals; cd14930"
                     /db_xref="CDD:276893"
     misc_feature    384..2417
                     /gene="Myh14"
                     /note="class II myosin heavy chain 14 motor domain;
                     Region: MYSc_Myh14_mammals; cd14930"
                     /db_xref="CDD:276893"
     misc_feature    order(465..491,621..644,804..836,1485..1502)
                     /gene="Myh14"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(465..491,621..644,804..836,1485..1502)
                     /gene="Myh14"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276893"
     misc_feature    465..491
                     /gene="Myh14"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    465..491
                     /gene="Myh14"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    621..644
                     /gene="Myh14"
                     /note="P-loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    621..644
                     /gene="Myh14"
                     /note="P-loop; other site"
                     /db_xref="CDD:276893"
     misc_feature    804..836
                     /gene="Myh14"
                     /note="switch I region; other site"
                     /db_xref="CDD:276893"
     misc_feature    804..836
                     /gene="Myh14"
                     /note="switch I region; other site"
                     /db_xref="CDD:276893"
     misc_feature    1485..1502
                     /gene="Myh14"
                     /note="switch II region; other site"
                     /db_xref="CDD:276893"
     misc_feature    1485..1502
                     /gene="Myh14"
                     /note="switch II region; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(1572..1607,1614..1643)
                     /gene="Myh14"
                     /note="relay loop [active]"
                     /db_xref="CDD:276893"
     misc_feature    order(1572..1607,1614..1643)
                     /gene="Myh14"
                     /note="relay loop [active]"
                     /db_xref="CDD:276893"
     misc_feature    2211..2240
                     /gene="Myh14"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276893"
     misc_feature    2211..2240
                     /gene="Myh14"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(2247..2297,2370..2417)
                     /gene="Myh14"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276893"
     misc_feature    order(2247..2297,2370..2417)
                     /gene="Myh14"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276893"
     misc_feature    2646..5888
                     /gene="Myh14"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:460256"
     misc_feature    2646..5888
                     /gene="Myh14"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:460256"
     exon            435..591
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            592..619
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            620..722
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            723..746
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            747..839
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            840..903
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1002
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1143
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1239
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1358
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1511
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1685
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1859
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1974
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2162
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2284
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2354
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2515
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2624
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2756
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2963
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3101
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3225
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3397
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3610
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3755
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3962
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4067
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4220
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4469
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4682
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4683..4895
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5057
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5186
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5275
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5399
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5608
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5609..5717
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5718..5890
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
     exon            5891..6443
                     /gene="Myh14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtccaggc cgaggcctct ggaccgccct gggcgccgac catggccaca gtgaccttgt
       61 ccgtgcctgg gaggaaggtg gcctccaggc caggcccggt gcctgaggca gcccagccat
      121 tcctgttcgc gccccggacg ccaaatgtag gtggccctgg agggccacag gtggagtgga
      181 cagcacggcg catggtgtgg gtgccctcgg aactgcatgg gttcgaggca gcagccctgc
      241 gggatgaagg ggaggaggag gcagaagtgg agctggcgga gagtgggcgg cgcctgcggc
      301 tgcccaggga ccagatccag cgcatgaacc cacccaagtt cagcaaggca gaagatatgg
      361 ctgagctcac ctgcctcaac gaggcctcgg tcctgcacaa tctgcgagag cgctactact
      421 ctgggctcat ttatacctac tctggcctct tctgtgtggt cattaacccg tacaagcagc
      481 tgcctatcta cacggaggcc attgttgaaa tgtaccgggg caagaagcgc cacgaggtgc
      541 cacctcacat ctatgccgtg accgagggcg cgtaccgcag catgcttcag gatcgtgagg
      601 atcagtccat tctctgcacg ggagagtctg gagctgggaa gacggagaac accaagaagg
      661 tcatccagta cctggcccat gtggcatcat ctccaaaggg caggaaggaa cctggtgtcc
      721 ctgcctccgt cagcaccatg tcttatgggg agctagagcg gcagcttctt caagccaacc
      781 ccatcctaga agccttcggc aatgccaaaa cggtgaagaa cgacaactct tcccgatttg
      841 gcaaattcat ccgcatcaac tttgatattg ctggctacat cgtgggagca aacatcgaga
      901 cctatctgct ggagaagtcc cgggccatca gacaggccaa ggacgaatgc agcttccata
      961 tcttctacca gctgctaggg ggcgctgggg agcagctaaa agctgacctc cttctggagc
     1021 cctactccca ttaccgcttc ctgaccaacg ggccctcatc atcccccggc caggagcggg
     1081 agttattcca ggagaccctg gagtccctgc gagtgctggg cctcctccca gaagagatca
     1141 ctgccatgct gcgcacagtc tcagctgtcc tccagtttgg caacattgtc ctgaagaaag
     1201 agcggaacac ggatcaagcc accatgcctg acaacacagc tgcccagaag ctttgccgcc
     1261 tcttgggact tggagtgact gacttctcca gagcccttct cacgccccgc atcaaagtcg
     1321 gccgagatta cgtccagaaa gcacagacca aagagcaggc tgactttgcg ctggaggctc
     1381 tggccaaagc tacctatgag cgcctgttcc gctggctggt tctgcggctc aaccgtgccc
     1441 tggacagaag cccacgtcag ggcgcctcct tcctgggcat cctggacatc gcaggctttg
     1501 agatcttcca gctgaactcc ttcgagcagc tgtgcatcaa ctacaccaat gagaagctgc
     1561 agcagctgtt caaccacacc atgttcgtgc tggagcagga ggagtaccag cgagaaggca
     1621 tcccctggac cttcctggac tttgggttgg acctgcagcc ttgtatcgac ctcattgagc
     1681 ggccggccaa ccctccaggt ctcctggccc tgctggacga ggagtgctgg ttccccaagg
     1741 ccactgacaa gtcttttgtg gagaaggttg cccaggagca gggcagccac cccaagttcc
     1801 agcgtcctag gaacctacga gatcaagcgg acttcagcgt cctgcactac gcaggcaagg
     1861 ttgactacaa agccaatgag tggttgatga agaacatgga tccattgaat gacaatgtgg
     1921 ccgccttgct tcaccagagc acagatcgtc tcacagctga gatctggaag gatgtggagg
     1981 gcatcgtggg gctggagcaa gtgagcagcc ttggagatgg ccccccggga ggccgccccc
     2041 gccgtggaat gttccggacc gtggggcagc tctacaaaga atccctgagc cgcctcatgg
     2101 ccacgctcag caacaccaac cctagttttg tccgctgcat cgttcccaat catgagaaga
     2161 gggctgggaa actggagccg cgcctggtgc tggaccagct ccgttgtaat ggtgtcctcg
     2221 agggtatccg catctgtcgc caaggtttcc ccaaccgcat cctctttcag gagttccggc
     2281 agcgctatga aatcctcacc ccgaacgcca ttcccaaggg cttcatggac ggcaaacagg
     2341 cctgtgagaa gatgatccag gccctggagc tagaccccaa cttgtaccgt gttggccaaa
     2401 gcaagatctt cttccgggca ggggtcctag ctcaactgga ggaggagcga gatctcaagg
     2461 tcaccgacat catagtatct tttcaggcag cggcacgggg ctacctggcc cgtagggctt
     2521 tccagaggag gcagcagcag cagagtgctc tgagggtgat gcagagaaac tgtgccgcct
     2581 acctcaagct gaggaactgg cagtggtgga gactgttcat caaggtgaag cccctgctgc
     2641 aggtgacacg gcaggatgag gtgctgcagg cgcgagccca ggagctacag aaagttcagg
     2701 agctgcagca gcagagcgcc cgtgaagtgg gggaactgca gggtcgagtg gcacagctag
     2761 aggaggagcg tgcgcgcctg gctgagcagc tgcgagcgga agcggagctg tgctctgagg
     2821 cggaggagac acgggcacga ttggctgccc ggaagcagga gctggagctg gtggtgacag
     2881 agctggaggc acgagtgggc gaggaagaag agtgcagccg gcagctacag agcgagaaga
     2941 agaggctgca gcagcacatc caggagctgg agacccacct agaagcagag gagggtgccc
     3001 ggcagaaact gcagctggag aaagtgacca cagaggccaa gatgaagaag tttgaggagg
     3061 atctgctgct cctggaagac cagaattcca agctgagcaa ggagcggagg ctgctggagg
     3121 agcgcctggc tgagttctcc tcacaggcag cagaagagga agagaaagtc aaaagcctta
     3181 acaagctgag ggtcaaatat gaagccacaa tcgcagacat ggaagaccga ctgaagaaag
     3241 aggagaaagg ccgccaggaa ctagagaagc tgaagcgacg gctggatggg gagagctcag
     3301 agcttcagga acagatgatg gagcagaagc agagggcaga ggagctgctc atacagctgg
     3361 gccgcaagga ggaagagctg cagtcggccc tggtcagggc agaggaggag ggtggtgccc
     3421 gtgctcagct gctcaagtct ctgcgagagg cacaggctgg ccttgctgag gcccaggagg
     3481 acctggaagc tgagcgggta gccagggcca aggcggagaa gcagcgccgg gacctgggcg
     3541 aggagttgga ggcgctccgc ggggagctag aggacacgct ggattccacc aacgcccagc
     3601 aggagctgcg gtccaagagg gagcaggagg tgacagagct gaaaaagact ttggaagagg
     3661 aggcccggac tcacgaggtg gccatgcagg agctgagaca gaggcatagc caggccctgg
     3721 tggagctgac agagcagttg gagcaagcac ggaggggcaa aagtgtgtgg gagaagaccc
     3781 ggctctccct ggaggctgag gtgtctgaac ttaagacgga gctgagcagc ctgcagacct
     3841 caagacagga gggtgagcag aagaggcgac gcctggagtc ccagctacag gaggtccagg
     3901 gccgatccag cgattccgag agggctcggg ctgaggctgc tgagaagcta cagagagccc
     3961 aggtggaact tgagagcgtg tccacagccc taagtgaggc tgagtccaag gccatcaggc
     4021 tgagcaagga gctgagcagt gcagagtccc agctgcacga cacccaggaa ctgctgcagg
     4081 aggagaccag ggcaaagctg gctttggggt cccgtgtgcg tgccctggag gccgaggcag
     4141 ccgggcttcg ggagcagatg gaagaggagg tggttgccag ggaacgggct ggccgagagc
     4201 tgcagaccac acaggcccag ctctctgaat ggcggcgacg ccaggaagaa gaggctgccg
     4261 tgctggaggc tggggaggag gctcggcgcc gtgcagcccg ggaggcagag accctggccc
     4321 agcgcctggc agaaaagact gaggctgtag aaagactgga gcgagcccgg cggcggctgc
     4381 agcaggagct ggacgacgcc actgtggacc tggggcagca gaaacagctc ctgagcacac
     4441 tggagaagaa gcagcgaaag tttgaccagc tcctggcaga ggagaaggct gcagtgctac
     4501 gggctgtgga agatcgtgaa cgggtagagg ctgaaggccg ggagcgagag gcccgggccc
     4561 tgtcgctgac acgggccctg gaagaggagc aggaggcacg ggaggagctg gagaggcaga
     4621 accgtgctct gcgggctgag ctggaggcac tgctaagcag caaggatgat gttggcaaga
     4681 atgtgcacga gctcgagcga gcccgcaggg tggctgaaca ggcagccagt gacctgcgga
     4741 cacaggtgac agaactggag gatgagctga ctgccgcgga ggatgccaaa ctgcgcctgg
     4801 aggtgactgt gcaggccctg aaggctcaac atgaacgcga cctgcagggc cgtgatgatg
     4861 ctggcgagga gaggcggagg cagctggcca agcagctgag agacgcagag gtagagcgcg
     4921 atgaggaacg gaagcagagg gcactggcca tggctgcccg caagaagctg gagttggaac
     4981 tggaggagtt gaaggcacag acatctgctg ctgggcaggg caaggaagag gcagtgaagc
     5041 agctgaagaa gatgcaggcc cagatgaagg agctgtggcg ggaggtggag gagacgcgta
     5101 gctcccgcga ggagatgttt accctgagca gggaaagtga gaagaggctc aaggggttgg
     5161 aagctgaggt gctgcggctg caggaggaac tggctgcctc agaccgagcc cggaggcagg
     5221 cacagcagga cagagatgag atggcagagg aggtggccag tggcaacctt agcaaggcag
     5281 ccaccctgga ggagaaacgg cagctggagg ggcgactggg ccagttggaa gaggagctgg
     5341 aggaagagca gaataactcg gagctgctca aggaccacta ccgaaagctg gtgctacagg
     5401 tagagaccct caccacagag ctgtctgctg aacgcagttt ctcagccaag gctgagagtg
     5461 gaaggcagca gctggagcgg cagatccagg aactgcgggc ccgcctgggt gaagaggatg
     5521 ctggagccag agccaggcag aaaatgctga tcgccgctct tgagtctaaa ctggcccagg
     5581 cagaggagca gctggagcag gagagcagag agcgcatcct ctctggcaag ctggtacgca
     5641 gagccgagaa gcggctgaag gaggtggttc ttcaggtgga tgaagagcgc agggtggctg
     5701 accagctccg ggaccagctg gagaaaagca acctccggct gaagcagctc aagagacagc
     5761 tggaggaggc agaggaggaa gcatctcggg cacaggctgg ccggaggcgt ctgcagcggg
     5821 agctggagga cgtcactgag tctgcagaat ccatgaaccg ggaggtgacc acgctgagga
     5881 acaggctccg gcgtggcccg cttactttca ccacgcgaac tgtgcgccag gtgttccggc
     5941 tggaagaggg cgtggcttcc gacgaggaag aggctgaggg ggcagagcct ggttctgcac
     6001 caacccagga gcctgaggct ccgccccctg ccgctcccca gtgatccagt ctgtccgaga
     6061 tgccccaagg acagagccct ttctggtgtc cctcctggtt tgcactttga aatgacactg
     6121 tcctctggca ctttctggca tcgatgaacc ctactgggac cccaggaccc ctgctcactg
     6181 gggactccaa atcaaggccc caaaccaagg agctgggtgg gagggaggca aggatggtcg
     6241 ctcatgttag agaaacaaaa ttgaacatgg atgtcaagga tgtccagtct gctcctgttt
     6301 tcagcaggcc tgtcccctgg agaggacagg agggtgcttc caccccctgt cttgctctct
     6361 ttggggggag gggtgctcat aggatagcgc tcatggtccc tcatgctcca gacactaaag
     6421 aaataaactg gctggaccct tca
//
LOCUS       NM_001437296             913 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437296
VERSION     NM_001437296.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.423247.1,
                                           SRR26360176.889585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-290             JAXUCZ010000011.1  44823304-44823443
            291-422             JAXUCZ010000011.1  44832669-44832800
            423-913             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..913
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..615
                     /gene="Mrps6"
                     /note="isoform 2 is encoded by transcript variant 3; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 2"
                     /protein_id="NP_001424225.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MPRYELALILKAMRRPETAAALKRTIESLMDRGAIVRNLENLGE
                     RALPYRISSHSQQHSRGGWWPSEFHLVVYRCIKLYTHNGHIESTFLHWAAEASPQGGD
                     LLPRYFLVDFYAPTNAVESMLEHLARDTDVVRPNIVKHPLTQEVKECDGIVPVPLEEK
                     LYSTKRRKK"
     misc_feature    112..525
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    112..525
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(115..117,250..252,262..264,451..453,460..465,
                     484..486,505..507,514..522)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(115..117,250..252,262..264,451..453,460..465,
                     484..486,505..507,514..522)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(118..120,124..126,238..240,244..252,424..426,
                     430..432,505..507,517..519)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(118..120,124..126,238..240,244..252,424..426,
                     430..432,505..507,517..519)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     exon            151..290
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            291..422
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            423..913
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg ccagagaccg ctgctgcttt aaaacgtaca
      181 atagaatccc tgatggaccg aggagccata gtgaggaact tggaaaacct gggtgagcgt
      241 gcactcccat acaggatctc cagtcacagc cagcagcaca gccgaggagg ttggtggccc
      301 agtgagttcc atcttgtggt ttacaggtgt ataaagctgt atacacataa cggccatata
      361 gaaagcacct tcctgcactg ggcagcagag gctagcccac aaggaggaga cttactgccc
      421 aggtatttct tggtggattt ttatgcccca acaaatgctg tggaaagcat gctggaacac
      481 ttggcacgag acactgatgt ggttagacca aatattgtga aacaccctct gacccaggaa
      541 gtaaaagagt gtgacggcat agtcccagtc cctcttgaag aaaaactgta ttcaacaaag
      601 agaaggaaga agtgagaaga ttcaccagat gtggctatgt tcaattctaa gtgcaccatg
      661 ggtgctgata ggtttgtcta ggatgcttta gcccgtgacc attttgctgc agatggggac
      721 tgctggccga gacctgctct gtcacccctg ctgatatttc accctcactg tgtgattgtc
      781 agggtgcggt ggggctggtg ttcacagtcc cactgcagag tttcgaagaa caaaatgttt
      841 gtcattcaca ctcggttgtc ttgtaaacct gtgtggaaca cagagcagag taataaacat
      901 ggttttatca aca
//
LOCUS       NM_001437307             645 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 186 member A
            (Fam186a), transcript variant 3, mRNA.
ACCESSION   NM_001437307
VERSION     NM_001437307.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1790288.1,
                                           SRR26360181.971413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000007.1  132935858-132936047 c
            191-339             JAXUCZ010000007.1  132934481-132934629 c
            340-519             JAXUCZ010000007.1  132933001-132933180 c
            520-645             JAXUCZ010000007.1  132922410-132922535 c
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..645
                     /gene="Fam186a"
                     /note="family with sequence similarity 186 member A"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
     exon            1..190
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Fam186a"
                     /note="upstream in-frame stop codon"
     exon            191..339
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..541
                     /gene="Fam186a"
                     /note="isoform 2 is encoded by transcript variant 3;
                     Protein FAM186A-like"
                     /codon_start=1
                     /product="family with sequence similarity 186 member A
                     isoform 2"
                     /protein_id="NP_001424236.1"
                     /db_xref="GeneID:100362820"
                     /db_xref="RGD:2323958"
                     /translation="MPSISSFKKIPKFTKLQRPVLDLLIDDSKRSDVFKRRGQAPVEA
                     VWNADLSTSSYPVVEKTPMNLLWAQLGGYPDIPKLLQLDIQSTLRKSLASICPRSKKI
                     RK"
     exon            340..519
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
     exon            520..645
                     /gene="Fam186a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggccacgc acagtctcaa gtcttcttac tggtgggtat caacagggct ctgtctcggg
       61 agcacggcag tgagagcttg ggatccgttc ccaaagttcc agcgtttgta tcatttcatt
      121 gggcggtaga tttgcgctct caggactcag agcttggggc cggtacacta gctcatcaga
      181 ctgccttggg cttgagaggg tgtttaaact aaatcttagc cagcccatgc cctccatctc
      241 cagctttaag aagataccca aattcaccaa acttcaacgg ccggtcttgg acttattgat
      301 tgatgacagc aaaagatccg atgttttcaa aagacgtggg caagccccag tggaggctgt
      361 gtggaatgct gacctgtcta catcaagcta cccagtggta gagaaaacac caatgaatct
      421 actctgggcc cagctgggcg ggtacccaga tattcccaaa ctgctgcagt tagatattca
      481 gtcgacctta agaaaatctc ttgcctccat ctgcccacgg tctaagaaga ttcgaaagtg
      541 aacacaaaac taaaagacaa gcacgtagaa atcaaatttc aatgtttcag taaaacgttg
      601 gtttttggct ttttgtctta cataaaatat taattattat gttta
//
LOCUS       NM_001191666            2821 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus trichoplein, keratin filament binding (Tchp),
            mRNA.
ACCESSION   NM_001191666 XM_006249451 XM_222232
VERSION     NM_001191666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Kasahara,K., Kawakami,Y., Kiyono,T., Yonemura,S., Kawamura,Y.,
            Era,S., Matsuzaki,F., Goshima,N. and Inagaki,M.
  TITLE     Ubiquitin-proteasome system controls ciliogenesis at the initial
            step of axoneme extension
  JOURNAL   Nat Commun 5, 5081 (2014)
   PUBMED   25270598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Veleri,S., Manjunath,S.H., Fariss,R.N., May-Simera,H., Brooks,M.,
            Foskett,T.A., Gao,C., Longo,T.A., Liu,P., Nagashima,K.,
            Rachel,R.A., Li,T., Dong,L. and Swaroop,A.
  TITLE     Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal
            appendages on the mother centriole during cilia biogenesis
  JOURNAL   Nat Commun 5, 4207 (2014)
   PUBMED   24947469
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Ibi,M., Zou,P., Inoko,A., Shiromizu,T., Matsuyama,M., Hayashi,Y.,
            Enomoto,M., Mori,D., Hirotsune,S., Kiyono,T., Tsukita,S., Goto,H.
            and Inagaki,M.
  TITLE     Trichoplein controls microtubule anchoring at the centrosome by
            binding to Odf2 and ninein
  JOURNAL   J Cell Sci 124 (Pt 6), 857-864 (2011)
   PUBMED   21325031
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Vecchione,A., Fassan,M., Anesti,V., Morrione,A., Goldoni,S.,
            Baldassarre,G., Byrne,D., D'Arca,D., Palazzo,J.P., Lloyd,J.,
            Scorrano,L., Gomella,L.G., Iozzo,R.V. and Baffa,R.
  TITLE     MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is
            downregulated in human bladder and breast cancer
  JOURNAL   Oncogene 28 (2), 257-269 (2009)
   PUBMED   18931701
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Nishizawa,M., Izawa,I., Inoko,A., Hayashi,Y., Nagata,K.,
            Yokoyama,T., Usukura,J. and Inagaki,M.
  TITLE     Identification of trichoplein, a novel keratin filament-binding
            protein
  JOURNAL   J Cell Sci 118 (Pt 5), 1081-1090 (2005)
   PUBMED   15731013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_006249451.4, NM_001191666.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.207504.1,
                                           SRR26643288.48215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000012.1  47553754-47553920   c
            168-352             JAXUCZ010000012.1  47552764-47552948   c
            353-563             JAXUCZ010000012.1  47552253-47552463   c
            564-620             JAXUCZ010000012.1  47550418-47550474   c
            621-689             JAXUCZ010000012.1  47548036-47548104   c
            690-863             JAXUCZ010000012.1  47546708-47546881   c
            864-976             JAXUCZ010000012.1  47545823-47545935   c
            977-1043            JAXUCZ010000012.1  47545632-47545698   c
            1044-1216           JAXUCZ010000012.1  47543797-47543969   c
            1217-1298           JAXUCZ010000012.1  47542683-47542764   c
            1299-1484           JAXUCZ010000012.1  47541285-47541470   c
            1485-1628           JAXUCZ010000012.1  47540540-47540683   c
            1629-2821           JAXUCZ010000012.1  47538519-47539711   c
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2821
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /note="trichoplein, keratin filament binding"
                     /db_xref="GeneID:304547"
                     /db_xref="RGD:1310813"
     exon            1..167
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    114..116
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /note="upstream in-frame stop codon"
     CDS             168..1661
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /codon_start=1
                     /product="trichoplein keratin filament-binding protein"
                     /protein_id="NP_001178595.1"
                     /db_xref="GeneID:304547"
                     /db_xref="RGD:1310813"
                     /translation="MALPTLPSYWSNRRPANIRYRQQQQEDEFRQQWEQNSRYFKTWD
                     LHNSKQTEWTSKTSYQRSMHALYCGKMEEERRKNLEVRRERLRKLMLEEQDLLAEELE
                     ELRLSMSLRERRLREQHRDLKSAREEQRKLMAEQLLYEHWRKNNPKLREIELDLHKKH
                     VINSWATQKEEKKQQEATEKQENKQFENEYAAARQEAEARLKAEEERKQLEGQLQGEA
                     LRQQMEELKQKEMEATKLKKEQENLLKQHWELERLDDERKQMAIVRRKTELGRILRHQ
                     YNAQLNRRTQQIQEELEADGRILQALLEKDNELQQVELARREQAMADAAQMKQVIEEQ
                     LQLEKAREAELQQLLREEAKEMWEKREAEWAREQSARDKLMSEVLTGRQQQIQEKIEQ
                     NRRAQEETLKYREELIKSLEEGKQLALRAKEESEELKSARKQELEAQVAERQFQEWEA
                     ARQEEEEEKEAKKAEQLSNARLQQEARTMVKRGYRPKIHGHLRIAWD"
     misc_feature    591..1610
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /note="Trichohyalin-plectin-homology domain; Region: TPH;
                     pfam13868"
                     /db_xref="CDD:464007"
     misc_feature    591..1610
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /note="Trichohyalin-plectin-homology domain; Region: TPH;
                     pfam13868"
                     /db_xref="CDD:464007"
     exon            168..352
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            353..563
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            564..620
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            621..689
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            690..863
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            864..976
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1043
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1216
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1298
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1484
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1628
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2821
                     /gene="Tchp"
                     /gene_synonym="RGD1310813"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcgcggt gctccgtcgt cccgagggct gcccggcaac cggcgaggaa acggctggcg
       61 tctgtgcagc gggcgcagcg ggaccctcgg agcctgcggg cgcgagatcg agctaaggcc
      121 ggcaactctt ctccgcgaac ctccggcgcc aggcgcagga gtcagagatg gcgctcccca
      181 cgctgccctc ttattggtcc aaccgcagac ccgcgaatat ccgctaccgc cagcaacagc
      241 aggaggacga gtttcgccag cagtgggagc agaacagtcg ctatttcaag acgtgggacc
      301 tccacaactc caaacagacc gaatggacct ccaagacctc ctaccagcga agcatgcacg
      361 ccctctactg tggcaagatg gaggaggaga ggaggaagaa tctggaggtc cggcgggaga
      421 gactcaggaa gcttatgctg gaggagcagg acttgctggc cgaagagctg gaggaactga
      481 ggctgagtat gagcctgcgg gagcgaagac tccgggagca gcacagggat ctgaagtcag
      541 cccgagaaga acaaaggaaa ctgatggctg aacaacttct gtatgaacac tggaggaaga
      601 acaacccgaa acttcgagag attgagttgg accttcacaa gaagcatgtg ataaattcct
      661 gggcaacaca gaaagaagaa aaaaaacagc aagaagccac tgagaagcag gaaaacaagc
      721 agtttgagaa cgagtatgcg gccgcccgcc aggaagctga ggccaggctg aaagccgagg
      781 aggagaggaa gcagctagag ggtcagctgc agggcgaggc tctgcgccag cagatggagg
      841 agctgaagca gaaggagatg gaggccacca aactgaagaa ggaacaggag aacctgctga
      901 agcagcactg ggaactggaa aggctggacg acgaaaggaa gcagatggcc atcgtccggc
      961 gcaagacaga gctagggcgc atcttgcgac atcagtacaa tgcgcagctc aacaggcgca
     1021 cccagcagat ccaggaggag ctggaggcag atgggcggat cctgcaggca ctgctggaga
     1081 aggacaatga gctgcagcaa gtcgaactgg ccaggcggga gcaagccatg gccgatgcgg
     1141 cccagatgaa gcaggtcatc gaggagcagc tgcagctgga gaaggcacgg gaggcagagc
     1201 tgcagcagct gctgagggaa gaggccaaag agatgtggga aaagagagaa gcagagtggg
     1261 ctcgagagca gagtgcgcgg gacaaactga tgagcgaggt tctgaccggc aggcagcagc
     1321 agatccaaga aaagattgaa cagaaccggc gagcacaaga ggagacccta aaatacaggg
     1381 aagaactcat caagagtctc gaggagggga agcagttagc tctgcgggca aaggaagaga
     1441 gtgaagagct gaagtcagcc aggaagcagg agctggaagc ccaggttgcg gagcgccagt
     1501 tccaggagtg ggaagcagcc cggcaggagg aggaggaaga gaaggaggcc aagaaggcag
     1561 aacagctctc caacgctcgg ctgcagcagg aggcgaggac catggtgaag aggggctaca
     1621 ggcccaagat tcatggacac ctcaggattg cctgggactg atgttgaaca cagagaagca
     1681 agccgacgtg acagagctcg cggcagttgt acagtgttgg ttctggccaa ggctcagggt
     1741 gctgctgacc acttgagcca tgcctgtgag gcgcatcatg gtccatagat gtcaggatgc
     1801 catgggtgtg cggccctgct gagagccctt ccctgccatc ctcacccaga caggccttac
     1861 agactcatgt ctacagtgcc acccgaggtc acacactgct ttataagtag attttagagc
     1921 tattcgaaga agtcatattc catgacagga tagtaggttc tcttgtctcc cctgtagttg
     1981 tctgctctag ggaggaccag gcagagggag gagacagcct tttaggtttt acagttgccg
     2041 ttagaagtta atctattgga ggcagactca taggtcttgg tgtagtgagt ttcagttgtg
     2101 agctgtgtag ccccaaggat cacatggtgt gtatttccga agagtggcag tctggaaaga
     2161 cagtgacaaa ggagcccttg tttggaagtg ttgtgagagc tacccatagg agctgggggt
     2221 gcttagtgtg gggtacttga cctttcacct atggtcctca cctcagctct acaccatcaa
     2281 gaagcagagt cctatagaga gcacttgagc ccaacacgtg ccacctctcg agtcctcagg
     2341 gtcacttggt tggctggccc aatagaaaca gggttgacag tgacctttcg agtgtggaga
     2401 aggcctatct atgtgcagcc ccatgggagt taggtgccca gaggaacact ggcgaaatgg
     2461 caggagactc agaatcacag atgagcgtgt ccccactgtt agatcccaat tcacctctgc
     2521 aagtggctct gggtcctggt cgcgagagtt ggattgttat gacttgtatc tctctgtagc
     2581 cttcatttcg tccctgtatt caagattctg ccaactttgc tgactatagg gtgtttgctc
     2641 tggtcatggg aacccagagt tagacgagcc tgggtttgag ggctgcattg cttctcagtc
     2701 tgtttcattt cctgccttgg ttctcggatg cggccccagc actgtttacc tcacacactt
     2761 ttgagcactc gcccttttca aatgcacact gactgtgaag taaagctctg tttcacctca
     2821 g
//
LOCUS       NM_001107133            5972 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus GRB10 interacting GYF protein 1 (Gigyf1), mRNA.
ACCESSION   NM_001107133 XM_001069187 XM_017598327 XM_222024
VERSION     NM_001107133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5972)
  AUTHORS   Ajiro,M., Nishidate,T., Katagiri,T. and Nakamura,Y.
  TITLE     Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary
            carcinogenesis
  JOURNAL   Int J Oncol 37 (5), 1085-1093 (2010)
   PUBMED   20878056
REFERENCE   2  (bases 1 to 5972)
  AUTHORS   Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
            Smith,R.J.
  TITLE     Two novel proteins that are linked to insulin-like growth factor
            (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
  JOURNAL   J Biol Chem 278 (34), 31564-31573 (2003)
   PUBMED   12771153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Apr 3, 2025 this sequence version replaced
            XM_017598327.3, NM_001107133.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.40781.1,
                                           SRR26643298.80020.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000012.1  24818208-24818373   c
            167-412             JAXUCZ010000012.1  24811551-24811796   c
            413-539             JAXUCZ010000012.1  24810525-24810651   c
            540-648             JAXUCZ010000012.1  24810209-24810317   c
            649-778             JAXUCZ010000012.1  24809982-24810111   c
            779-874             JAXUCZ010000012.1  24809788-24809883   c
            875-986             JAXUCZ010000012.1  24809578-24809689   c
            987-1095            JAXUCZ010000012.1  24809349-24809457   c
            1096-1136           JAXUCZ010000012.1  24808901-24808941   c
            1137-1301           JAXUCZ010000012.1  24808598-24808762   c
            1302-1555           JAXUCZ010000012.1  24808156-24808409   c
            1556-1664           JAXUCZ010000012.1  24807963-24808071   c
            1665-1796           JAXUCZ010000012.1  24806931-24807062   c
            1797-1900           JAXUCZ010000012.1  24806685-24806788   c
            1901-2072           JAXUCZ010000012.1  24806358-24806529   c
            2073-2239           JAXUCZ010000012.1  24806081-24806247   c
            2240-2340           JAXUCZ010000012.1  24805845-24805945   c
            2341-2457           JAXUCZ010000012.1  24805650-24805766   c
            2458-2558           JAXUCZ010000012.1  24805421-24805521   c
            2559-2641           JAXUCZ010000012.1  24805051-24805133   c
            2642-2785           JAXUCZ010000012.1  24804826-24804969   c
            2786-3010           JAXUCZ010000012.1  24804523-24804747   c
            3011-3201           JAXUCZ010000012.1  24804096-24804286   c
            3202-3362           JAXUCZ010000012.1  24803841-24804001   c
            3363-3559           JAXUCZ010000012.1  24803563-24803759   c
            3560-3689           JAXUCZ010000012.1  24803365-24803494   c
            3690-5972           JAXUCZ010000012.1  24800994-24803276   c
FEATURES             Location/Qualifiers
     source          1..5972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..5972
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="GRB10 interacting GYF protein 1"
                     /db_xref="GeneID:304378"
                     /db_xref="RGD:1309933"
     exon            1..166
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..412
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..539
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    428..430
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="upstream in-frame stop codon"
     exon            540..648
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     CDS             614..3742
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="PERQ amino acid rich, with GYF domain 1; PERQ amino
                     acid-rich with GYF domain-containing protein 1"
                     /codon_start=1
                     /product="GRB10-interacting GYF protein 1"
                     /protein_id="NP_001100603.1"
                     /db_xref="GeneID:304378"
                     /db_xref="RGD:1309933"
                     /translation="MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGRE
                     EMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEDEQRNFSLSVNSVAVLRL
                     MGKGAGPPLAATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDD
                     RGERRFEKSARRDGVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDSSWRLGAGPR
                     RDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRC
                     RGLDGFEDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEE
                     EEEEPSDGVDEEGPEAGGKEVTPLPPSEKSSSPSSLPALGPLWTANEDGEAVEKELPP
                     AEGDEMRGLPLSPRISSPPAGPPADLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTA
                     AMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLL
                     VKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQ
                     HQHFLQLVGSRQLPQCATLREKAAMGDLTPPQQQLTTFLQQLQALKTPRGGDQNLLPT
                     MSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERRE
                     VELRVKREEEERKRREEKRRQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQA
                     TNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQPAPREPLRAQAPNHR
                     VQLGGLGTAPLNQWVSEAGPLWGGPDKSGGSSSGNLGLWEDTLKSGGSLARSLGLKNS
                     RSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTSS
                     LDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQ
                     QQQQQQQQQQEAWLSSSSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLH
                     GPSGEIESVDDY"
     misc_feature    947..>1408
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="transcription termination factor Rho; Provisional;
                     Region: PRK12678"
                     /db_xref="CDD:237171"
     misc_feature    947..>1408
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="transcription termination factor Rho; Provisional;
                     Region: PRK12678"
                     /db_xref="CDD:237171"
     misc_feature    2036..2197
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="GYF domain: contains conserved Gly-Tyr-Phe
                     residues; Proline-binding domain in CD2-binding and other
                     proteins. Involved in signaling lymphocyte activity. Also
                     present in other unrelated proteins (mainly unknown)
                     derived from diverse eukaryotic species; Region: GYF;
                     cd00072"
                     /db_xref="CDD:238027"
     misc_feature    2036..2197
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="GYF domain: contains conserved Gly-Tyr-Phe
                     residues; Proline-binding domain in CD2-binding and other
                     proteins. Involved in signaling lymphocyte activity. Also
                     present in other unrelated proteins (mainly unknown)
                     derived from diverse eukaryotic species; Region: GYF;
                     cd00072"
                     /db_xref="CDD:238027"
     misc_feature    2072..2122
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="proline binding motif [active]"
                     /db_xref="CDD:238027"
     misc_feature    2072..2122
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="proline binding motif [active]"
                     /db_xref="CDD:238027"
     misc_feature    order(2102..2104,2117..2122)
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="proline interaction residues [active]"
                     /db_xref="CDD:238027"
     misc_feature    order(2102..2104,2117..2122)
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /note="proline interaction residues [active]"
                     /db_xref="CDD:238027"
     exon            649..778
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..874
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..986
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1095
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1136
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1301
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1555
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1664
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1796
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1900
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2072
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2239
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2340
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2457
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2558
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2641
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2785
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3010
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3201
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3362
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3559
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3689
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..5972
                     /gene="Gigyf1"
                     /gene_synonym="Perq1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctacaaaca caaacagaga ggagcggccg ccgcgggagc gccagcgccc ccccagtccc
       61 ccccttgccg ccgccgtccc ggcccgccgc gcgccacccg cccgtcaccg ccaccaccgc
      121 gcccgggtca ccaacgcccc gggggaccgg gaacctcgcg cccccgactc ctggcatcct
      181 gcagcggatg gggactgcag aggcacactg gtccagcctc ctgctcagcc agtgataaaa
      241 aaaacccacg tactacccct ggacactgcc tgcccttcct cctctcctct gcccttgctg
      301 gatgaacccc tacctgagag tctcctaccc aggcccctag aggaaccttc ccgtgttgct
      361 gccactgccg cctcactagc cgctggagac tgaacttgcc tcttcccgta tggatctttc
      421 ccagatgtga aggtttctcc caggcacttc tgaggctaga gctagttgct tggggattct
      481 agttccccca gcccaggccc tgctagacaa gagccttgtt tcacggacag gactgtcagg
      541 tatttggaca gtacacgcct ggtcctctct cctccattca tccttgacct gtgagaagca
      601 tcccatctcc acaatggcag cggagacact caactttggg cctgagtggc tgagagccct
      661 ttccagcggt ggcagcgtgg cctctccacc cccatcccct gccatgccca agtacaagct
      721 ggcagattac cgctatgggc gagaggagat gctggccctc tatgtcaagg agaacaaggt
      781 tcccgaggaa ctacaggaca aggagtttgc tgcagtgtta caggaggagc cgctgcagcc
      841 cctggctctg gagcctctca ctgaggatga gcagagaaac ttctccctgt cggtgaacag
      901 tgtggctgtg ctgaggctga tgggaaaagg ggctgggccc cctttggctg ccacctcccg
      961 tggcaggggc agcactcgga gccgagggcg aggccgtggt gacagctgct tttaccaaag
     1021 aagcattgag gaaggcgatg gggcctttgg acgcaatcct cgggagatcc agcgaagcca
     1081 gagctgggac gacagaggtg agaggcggtt tgagaagtct gcaaggaggg atggagtacg
     1141 atctggcttt gaggagggag gggctggccc gaggaaggag catgcgcgct cagacagtga
     1201 gaattggcgc tcacttcgag aggagcaaga ggatgatagc agctggagac ttggggcagg
     1261 accccggcga gatggtgatc gctggcgttc caccagtcct gacggtggtc cccgctctgc
     1321 tggctggcgg gagcatggag agcggaggcg caagtttgat tttgatttgc gaggggaacg
     1381 cggaggttgt ggtgaagaag atgggcgagt tgggggaggc aactcacacc tccgaagatg
     1441 ccgggggctg gatggctttg aagatgacaa ggatgggctc ccagagtggt gcctggatga
     1501 tgaggatgag gagatgggta cttttgatgc ttctggagcc ttcctgcctc ttaagaaggg
     1561 ccccaaggaa cctattccag aggagcaaga gcttgatttc cagggcctgg aggaagagga
     1621 agaggaacca tcagatgggg tggatgaaga ggggcctgag gccggaggga aggaagtgac
     1681 cccattgcct ccttcagaga agtcgagctc cccatcctca ctgcctgcct tgggccctct
     1741 ctggacagcg aatgaagatg gtgaggcagt ggagaaagag ctgcccccgg ctgaaggaga
     1801 cgagatgagg ggactgcctc taagtccaag aatcagttcc cctcctgcag gcccgcctgc
     1861 agacctagaa gatgaagaag gcttgaagca cttgcaacag gaggcagaga agctggtggc
     1921 ctccctgcag gacagctccc tggaggagga gcagttcact gctgccatgc agacccaggg
     1981 cctacgccac tccacagccg ccactgccct tcccctcagc catggcgctg cccgaaagtg
     2041 gttctacaag gacccacagg gagagatcca aggccctttc acaacccagg agatggctga
     2101 gtggttccag gctggctact tctccatgtc cctcttagtg aagaggggct gcgatgaggg
     2161 tttccagcct ctgggagagg tgatcaagat gtggggccgt gtgccctttg ccccagggcc
     2221 ctcgccaccc ccgctgctgg ggaacatgga tcaggagcgg ctgaagaagc agcaggagct
     2281 ggctgcggca gccctgtacc agcagctgca gcaccagcac tttctgcagc tggttggcag
     2341 ccgccagctc ccgcagtgtg cgacactccg ggaaaaggca gctatggggg acctgacgcc
     2401 gccgcagcag cagctcacta cgttcctgca gcagctccag gctctcaaaa cccccagagg
     2461 tggggaccag aacctgctcc cgacaatgag ccggtccttg tcggtgccag attcaggccc
     2521 cctctgggac ttacatacct cagcttcatc acagtcaggt ggtgaggcca gtctttggga
     2581 cataccaatt aactcttcga ctcagggtcc aattctagaa caactccagc tgcaacacaa
     2641 atttcaagaa cgcagagaag tggagctcag ggtgaagcgg gaggaggagg agcgcaaacg
     2701 ccgggaggag aagcgtcgcc agcagcagca gcaggaggag cagaagcggc gtcaggagga
     2761 ggaggagctc tttcgacgca agcaggtgcg gcagcaggaa ctgttgctga agctgctaca
     2821 gcagcagcag gcgacgaatg tccctgtgcc ccctgcaccc agctccccac ccccactctg
     2881 ggctggccta gccaagcagg gcctgtccat gaagactctg ctggagctgc agatggaaag
     2941 tgagcgccaa ctgcacaagc agccggcacc acgggagcct ctgcgggccc aggcccccaa
     3001 ccaccgagtg caacttgggg gcttgggcac tgcccctctg aaccagtggg tgtctgaggc
     3061 tgggccactg tggggcgggc cagacaagag tgggggcagc agcagtggca acctgggact
     3121 ctgggaagac actctcaaga gtggcgggag cctggcccga agcctgggcc taaagaacag
     3181 tcggagcagc ccgtctctca gtgactccta cagccacctg tcaggtcgac ctgttcgcaa
     3241 aaagaccgaa gaggaagaga agttgctgaa gctgctacag ggcatccctc ggccccagga
     3301 tggcttcacc caatggtgtg agcagatgct gcacactctg agcaccacaa gcagcctgga
     3361 tgttcccatg gctgtagcga tcctcaagga ggtggagtcc ccttatgatg tccatgatta
     3421 tattcgttcc tgcctggggg acacgctgga agccaaagaa tttgccaaac aattcctgga
     3481 gcggagggcc aagcagaaag ccagccaaca gcggcagcag caacagcagc agcagcagca
     3541 gcagcaacag cagcagcagg aggcctggct gagcagcagc tccctacaga cagcctttca
     3601 ggccaaccac agcaccaaac tgggccctgg ggagggcagc aaggccaaga ggcgggcgct
     3661 gatgcttcac tctgacccca gcatcttggg gtactccctg cacggccctt ccggtgagat
     3721 cgagagcgtg gatgactact gaccagcctg tcccaccagc cccctgggct ctacactcgg
     3781 gtggcggcag catagacctt tgggtctccg gcctgcaggc tcccagcaag gagcagagga
     3841 ggaagcaagc ggggcagggt ccccagcact tgttacaaac cacacgatgc accttaactc
     3901 acccaccacg aggcacttta cagatggggg aggggctttt ttttctcttt aattttaaac
     3961 cttaggagag acaaaagtat cattcaaaag ctagacggta ggccccttca cccctttggg
     4021 gataatgggt gtgacattgg aaggtccaca gaggtttggg ggttcttttt gttttgtttt
     4081 gtttttattt tttattttta gaaaaaaaga aaaaataatg aaaaaaaagt taggctgaaa
     4141 ggaaaaaaaa tcacactgtt attttcggcc agtgggtacc aggccccatg gaactgtcct
     4201 ggctggctcc cctgaggctg cacttactct gctgcctgcc cctagaaggt gggtcattgg
     4261 ggtaactgtc agctgggtgc tggcagtctg cacagcgagg cccctccaga agccccaccc
     4321 gctggaccag ctgtggtccg cttcctgggg caggtaccgt ggcaggtgtc ctggtcaggg
     4381 gccatagtcg ccccttgcct cagctgcttt gggaggaacg ttgcacaaat tggatgagct
     4441 gcctcagctc cctcttcccc aagccccctc aacagccctc ccacaccggc tgaggggagc
     4501 tggggaaaga cctgtcagtg ccagcctgtc aggtaggctc tgaactcagg cctgctgagg
     4561 ggctgccccc cactgctgcc attccggggg acagccgggg tgacactgaa agccccagct
     4621 ccctgccttt gccacatgaa tgtattctct ggcccccaag cctgtctcac cctctctgag
     4681 aagggacaca gcccttcctc caggagctgg agaccaccac ctccttttat catggctgag
     4741 gccttgctta tgtgagggga ggaccctgaa ggagtggctt ggggctgaac ctgtggtgga
     4801 gggcctaggt gggagccccc tgatgggagc cccctgatgt gcagccagtg gtgtgggaag
     4861 tagaccacag ctctgtacct ggacccctcc attgaccaaa tgggagagga gttagcagcc
     4921 cctctccttg atgtttccca tgctgggtgt aaggctggag gttgaaagcg cctgtgtcct
     4981 gggctggggg ctgccttgcc tgttgctcac cgacttcact cctagtcccc ccgcctgggc
     5041 ttgtctccat cttgtttggc tttccccctt ttcgttttaa tgtactgtgt tagtgagctc
     5101 tcccatcggc ctcattgctc agaatgcagt attagggcga gcctgtcact gcctcctcca
     5161 tgaatgtatt tctcttttct gccctgggga agtggggagt ggccccaggt ttctttccca
     5221 tccatcccca gagaggtgac cttctgtttt cctttcaact tttttttttc tttttccttt
     5281 ttttttaatt ttttttaaaa tttttttttt tttgcaccaa agtggcaact gggtcagtgt
     5341 tggggatcag gctggctctg ggtggaagtc ccctccacct gcttctccct ggctttgaca
     5401 gtgttagcgt ctgtgaaaag acaatattct ctctaaagca ataagggggt gatgggccag
     5461 ggggaaatgt cttgctgctg ctggcccccc agctcccctt ccctcttgcc actgtggtgg
     5521 cattggaggg gtgggagaga ctcctgttgt gactgaatgt aacctaccct gcccctgcca
     5581 cagccaatgc agggggaggg gaacacttgt ctcttcctac cccttccccc agctaaagag
     5641 actttgaact tgggggccca tgagcctgga gaggccttaa ccctgtgagg aagtgtaggg
     5701 ggagccctct cccaccccat cccctctgag agtggtcaat gtttacaagc cctgagccct
     5761 aacccaggga ctcagacgct ccccacccca tcttaatcct ttccccatcc cagtcttaca
     5821 gggccctgct gctccaccct ggcccccttg gggttcaggg tagtgtaggt atcctgtgta
     5881 tcccagttta ccctacctct accctgtgtg acttccctaa tacccactct tgtaaatact
     5941 cccaataaaa ctcggtgtgt tctcccagtc ta
//
LOCUS       NM_001107465            7877 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus chromodomain helicase DNA binding protein 1
            (Chd1), mRNA.
ACCESSION   NM_001107465 XM_001056703 XM_039110776 XM_238731
VERSION     NM_001107465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7877)
  AUTHORS   Pilarowski,G.O., Vernon,H.J., Applegate,C.D., Boukas,L., Cho,M.T.,
            Gurnett,C.A., Benke,P.J., Beaver,E., Heeley,J.M., Medne,L.,
            Krantz,I.D., Azage,M., Niyazov,D., Henderson,L.B., Wentzensen,I.M.,
            Baskin,B., Sacoto,M.J.G., Bowman,G.D. and Bjornsson,H.T.
  TITLE     Missense variants in the chromatin remodeler CHD1 are associated
            with neurodevelopmental disability
  JOURNAL   J Med Genet 55 (8), 561-566 (2018)
   PUBMED   28866611
REFERENCE   2  (bases 1 to 7877)
  AUTHORS   Rodgers,M.J., Banks,D.J., Bradley,K.A. and Young,J.A.
  TITLE     CHD1 and CHD2 are positive regulators of HIV-1 gene expression
  JOURNAL   Virol J 11, 180 (2014)
   PUBMED   25297984
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7877)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   4  (bases 1 to 7877)
  AUTHORS   Huang,S., Gulzar,Z.G., Salari,K., Lapointe,J., Brooks,J.D. and
            Pollack,J.R.
  TITLE     Recurrent deletion of CHD1 in prostate cancer with relevance to
            cell invasiveness
  JOURNAL   Oncogene 31 (37), 4164-4170 (2012)
   PUBMED   22179824
REFERENCE   5  (bases 1 to 7877)
  AUTHORS   Grasso,C.S., Wu,Y.M., Robinson,D.R., Cao,X., Dhanasekaran,S.M.,
            Khan,A.P., Quist,M.J., Jing,X., Lonigro,R.J., Brenner,J.C.,
            Asangani,I.A., Ateeq,B., Chun,S.Y., Siddiqui,J., Sam,L.,
            Anstett,M., Mehra,R., Prensner,J.R., Palanisamy,N., Ryslik,G.A.,
            Vandin,F., Raphael,B.J., Kunju,L.P., Rhodes,D.R., Pienta,K.J.,
            Chinnaiyan,A.M. and Tomlins,S.A.
  TITLE     The mutational landscape of lethal castration-resistant prostate
            cancer
  JOURNAL   Nature 487 (7406), 239-243 (2012)
   PUBMED   22722839
REFERENCE   6  (bases 1 to 7877)
  AUTHORS   Dey,P., Ponnusamy,M.P., Deb,S. and Batra,S.K.
  TITLE     Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates
            histone methylation and chromatin remodeling in pancreatic cancer
  JOURNAL   PLoS One 6 (10), e26926 (2011)
   PUBMED   22046413
REFERENCE   7  (bases 1 to 7877)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   8  (bases 1 to 7877)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 7877)
  AUTHORS   Chen,Y.X., Yan,J., Keeshan,K., Tubbs,A.T., Wang,H., Silva,A.,
            Brown,E.J., Hess,J.L., Pear,W.S. and Hua,X.
  TITLE     The tumor suppressor menin regulates hematopoiesis and myeloid
            transformation by influencing Hox gene expression
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 1018-1023 (2006)
   PUBMED   16415155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 4, 2025 this sequence version replaced
            XM_039110776.2, NM_001107465.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.745.1, SRR26643292.789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JAXUCZ010000001.1  65335255-65335580
            327-527             JAXUCZ010000001.1  65337223-65337423
            528-729             JAXUCZ010000001.1  65354269-65354470
            730-843             JAXUCZ010000001.1  65355286-65355399
            844-908             JAXUCZ010000001.1  65357173-65357237
            909-1058            JAXUCZ010000001.1  65360285-65360434
            1059-1327           JAXUCZ010000001.1  65360567-65360835
            1328-1553           JAXUCZ010000001.1  65361669-65361894
            1554-1654           JAXUCZ010000001.1  65362346-65362446
            1655-1833           JAXUCZ010000001.1  65362781-65362959
            1834-1961           JAXUCZ010000001.1  65364142-65364269
            1962-2178           JAXUCZ010000001.1  65365309-65365525
            2179-2268           JAXUCZ010000001.1  65366563-65366652
            2269-2459           JAXUCZ010000001.1  65367418-65367608
            2460-2648           JAXUCZ010000001.1  65368531-65368719
            2649-2811           JAXUCZ010000001.1  65370962-65371124
            2812-2964           JAXUCZ010000001.1  65371887-65372039
            2965-3036           JAXUCZ010000001.1  65373058-65373129
            3037-3186           JAXUCZ010000001.1  65373363-65373512
            3187-3335           JAXUCZ010000001.1  65375068-65375216
            3336-3432           JAXUCZ010000001.1  65375550-65375646
            3433-3528           JAXUCZ010000001.1  65375736-65375831
            3529-3705           JAXUCZ010000001.1  65377691-65377867
            3706-3866           JAXUCZ010000001.1  65380408-65380568
            3867-3908           JAXUCZ010000001.1  65382285-65382326
            3909-4039           JAXUCZ010000001.1  65383581-65383711
            4040-4178           JAXUCZ010000001.1  65384269-65384407
            4179-4329           JAXUCZ010000001.1  65384574-65384724
            4330-4452           JAXUCZ010000001.1  65386563-65386685
            4453-4581           JAXUCZ010000001.1  65387431-65387559
            4582-4722           JAXUCZ010000001.1  65388671-65388811
            4723-4901           JAXUCZ010000001.1  65392343-65392521
            4902-4998           JAXUCZ010000001.1  65395957-65396053
            4999-5053           JAXUCZ010000001.1  65396950-65397004
            5054-5264           JAXUCZ010000001.1  65398271-65398481
            5265-7877           JAXUCZ010000001.1  65399658-65402270
FEATURES             Location/Qualifiers
     source          1..7877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..7877
                     /gene="Chd1"
                     /note="chromodomain helicase DNA binding protein 1"
                     /db_xref="GeneID:308215"
                     /db_xref="RGD:1306794"
     exon            1..326
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..527
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    454..456
                     /gene="Chd1"
                     /note="upstream in-frame stop codon"
     CDS             475..5610
                     /gene="Chd1"
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 1"
                     /protein_id="NP_001100935.1"
                     /db_xref="GeneID:308215"
                     /db_xref="RGD:1306794"
                     /translation="MNGHSDEESVRNGSGESSQSEDDSGSASGSGSGSSSGSSSDGSS
                     SQSGSSDSDSGSDSGSQSESESDTSRENKVQAKPPKVDGAEFWKSNPSILAVQRSAML
                     RKQTQQPQQQRPASSNSGSEEDSSSSEDSDASSSDVKRKKHNDEDWQMSGSGSPSQSG
                     SDSESEDERDKSSCDGTESDYEPKNKVKSRKPQNRSKSKSGKKILGQKKRQIDSSEDE
                     DDEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQTEDEEFETIERFM
                     DCRVGRKGATGATTTIYAIEADGDPNAGFEKSKEPGDVQYLIKWKGWSHIHNTWETEE
                     TLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERI
                     IAHSNQKSAAGLPDYYCKWQGLPYSECSWEDGALISKKFQTCIDEYFSRNQSKTTPFK
                     DCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGL
                     GKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSR
                     NMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLL
                     YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYA
                     SLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSK
                     GSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRL
                     RERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRRQALDHFNAEGSEDF
                     CFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKG
                     SVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAE
                     ELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDI
                     ELEPERNSKNWEDIIPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRS
                     RSRRYSGSDSDSISERKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERL
                     DAIARDAELVDKSETDLRRLGELVHNGCVKALKDSSSGTERAGGRLGKVKGPTFRISG
                     VQVNAKLVIAHEDELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIG
                     IYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEA
                     QRLSGAGGSKRRKTRAKKNKAMKSIKVKEEIKSDSSPLPSERSEEEDDNVNDSKPESK
                     DRSKKSVVSDAPVHITASGEPVPIAEESEELDQKTFSICKERMRPVKAALKQLDRPEK
                     GLSEREQLEHTRQCLIKIGDHITECLKEYSNPEQIKQWRKNLWIFVSKFTEFDARKLH
                     KLYKHAIKKRQESQQNSDQNSNVPTTHVIRNPDMERLKENTNHDDSSRDGYSSDRHLS
                     QCHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHREWDHYRQDSRYYSDREKHRKLDD
                     HRSREHRPSVEGSLKDRCHSDHRSHSDHRMHSDHRSSTEHTHHKSSRDYRYLSDWQLD
                     HRAASSGPRSPLDQRSPYGSRSPFEHSAEHRSTPEHTWSSRKT"
     misc_feature    1276..1530
                     /gene="Chd1"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; Region: CD1_tandem_CHD1-2_like; cd18666"
                     /db_xref="CDD:349313"
     misc_feature    1276..1530
                     /gene="Chd1"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; Region: CD1_tandem_CHD1-2_like; cd18666"
                     /db_xref="CDD:349313"
     misc_feature    order(1282..1284,1432..1434,1438..1443,1453..1455)
                     /gene="Chd1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349313"
     misc_feature    order(1282..1284,1432..1434,1438..1443,1453..1455)
                     /gene="Chd1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349313"
     misc_feature    1627..1797
                     /gene="Chd1"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; Region: CD2_tandem_CHD1-2_like; cd18661"
                     /db_xref="CDD:349308"
     misc_feature    1627..1797
                     /gene="Chd1"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; Region: CD2_tandem_CHD1-2_like; cd18661"
                     /db_xref="CDD:349308"
     misc_feature    order(1690..1692,1741..1743)
                     /gene="Chd1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349308"
     misc_feature    order(1690..1692,1741..1743)
                     /gene="Chd1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349308"
     misc_feature    1846..2559
                     /gene="Chd1"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:475120"
     misc_feature    1846..2559
                     /gene="Chd1"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:475120"
     misc_feature    1858..>3468
                     /gene="Chd1"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     misc_feature    1858..>3468
                     /gene="Chd1"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     misc_feature    order(1990..2010,2308..2310)
                     /gene="Chd1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     misc_feature    order(1990..2010,2308..2310)
                     /gene="Chd1"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     misc_feature    3838..4098
                     /gene="Chd1"
                     /note="CDH1/2 SANT-Helical linker 1; Region:
                     CDH1_2_SANT_HL1; cl39715"
                     /db_xref="CDD:477096"
     misc_feature    3838..4098
                     /gene="Chd1"
                     /note="CDH1/2 SANT-Helical linker 1; Region:
                     CDH1_2_SANT_HL1; cl39715"
                     /db_xref="CDD:477096"
     misc_feature    <4348..5196
                     /gene="Chd1"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    <4348..5196
                     /gene="Chd1"
                     /note="MAEBL; Provisional; Region: PTZ00121"
                     /db_xref="CDD:173412"
     misc_feature    4696..4968
                     /gene="Chd1"
                     /note="Domain of unknown function (DUF4208); Region:
                     DUF4208; pfam13907"
                     /db_xref="CDD:464035"
     misc_feature    4696..4968
                     /gene="Chd1"
                     /note="Domain of unknown function (DUF4208); Region:
                     DUF4208; pfam13907"
                     /db_xref="CDD:464035"
     misc_feature    5245..>5547
                     /gene="Chd1"
                     /note="E4 protein; Provisional; Region: PHA03420"
                     /db_xref="CDD:177648"
     misc_feature    5245..>5547
                     /gene="Chd1"
                     /note="E4 protein; Provisional; Region: PHA03420"
                     /db_xref="CDD:177648"
     exon            528..729
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..843
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..908
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1058
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1327
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1553
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1654
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1833
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1961
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2178
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2268
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2459
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2648
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2811
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2964
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3036
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3186
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3335
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3432
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3528
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3705
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3866
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..3908
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4039
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4178
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4329
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4452
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4581
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4582..4722
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4901
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..4998
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5053
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5264
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5265..7877
                     /gene="Chd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctcggcg gcgccgcgcg gcggagacgg ttgcgctcga tcgcggtctt ggcgtcatgg
       61 cggctgccgg cggccgataa gcggcggggc gggagcgcgg acggaggagg cgccttcggt
      121 acttcccgct cgccctcggc gcccggagat gaactgatcg taggacccgc ttcccagccc
      181 ctcacgtctc cgcccgcggc ctcccctccc cctctgccgt ccgcggcgcg ggtcccgcgg
      241 cctgggcgtc caggatcgcg ggccccgcgc ggggcatcct ccgcctgagg cgccggcccg
      301 cgccaccctt cgccctgtgc ccgccggtga catagagagg gggccctgga aacccgtgga
      361 tgttgaagaa aattcatctt tgaacttttg atattcgagg aaatcggcat tcatactcgt
      421 cttttattat tctgaggaga tttgtgtttt atttaaaact tgttgatctt tacaatgaat
      481 ggacacagtg atgaagaaag tgttagaaat ggcagcggag aatcaagtca gtcagaagat
      541 gattctgggt cagcatcagg ctctggatct ggctcaagct ctggcagcag cagtgatggg
      601 agcagcagcc agtctgggag cagcgactct gattctggtt ctgactccgg aagtcaatca
      661 gagtctgagt cagacacatc ccgagagaac aaagttcaag caaaaccacc aaaagttgat
      721 ggagctgagt tttggaaatc taaccccagt attctggctg ttcagagatc tgcaatgctt
      781 aggaagcaga cacagcagcc tcagcagcag cgcccagctt catctaatag tggatccgaa
      841 gaggattcct ctagcagtga agactcagac gcctcgtcca gcgatgtcaa gaggaaaaag
      901 cataacgatg aagattggca aatgtctggg tctggatctc catctcagtc tggttcagac
      961 tcagaatctg aagacgagag agataaaagt agctgtgatg ggacagagtc tgattatgag
     1021 ccaaaaaaca aagtcaaaag cagaaaacct cagaatagat ctaagtcaaa aagtgggaaa
     1081 aaaattcttg gacagaaaaa gaggcagatt gattcgtctg aggatgaaga tgatgaggac
     1141 tacgataatg ataaacgaag ctctcgacgc caggccaccg tcaatgtgag ctacaaggag
     1201 gatgaagaga tgaaaactga ctctgatgac ctgctggagg tctgcggaga ggacgtccct
     1261 cagacggagg atgaggagtt tgagaccata gaaaggttta tggattgcag agttgggcgg
     1321 aaaggagcta ctggtgctac tacaaccatt tatgctattg aagcagatgg tgacccaaat
     1381 gcaggattcg aaaaaagcaa agagccggga gacgtccagt atttaattaa gtggaaaggg
     1441 tggtcgcaca tccataacac gtgggagacg gaagaaaccc tcaagcagca gaacgttaga
     1501 gggatgaaaa agttggataa ttataagaaa aaagatcagg agacaaaacg atggctgaaa
     1561 aatgcttctc cggaagatgt ggaatattac aactgccagc aagagcttac cgatgacctc
     1621 cacaaacagt accagatagt ggagcgcata attgctcatt ccaatcagaa gtcagcagct
     1681 ggtcttcctg attactattg caaatggcag gggcttccct actctgagtg cagctgggag
     1741 gacggagcgc tcatttccaa aaagttccag acgtgtatcg atgagtattt tagcaggaat
     1801 cagtcaaaaa ctacaccttt taaagattgc aaagtactga aacaaagacc aagatttgta
     1861 gctctgaaga aacaaccatc ctatattgga ggacatgagg gtttagaatt gagagactat
     1921 cagctgaatg gtttaaactg gcttgctcac tcttggtgca aaggaaatag ttgcatactt
     1981 gctgatgaaa tgggccttgg aaaaacgata cagaccatct catttttgaa ctatttgttt
     2041 catgaacatc agttatacgg accttttcta ctagttgtcc cgctctccac tctgacttcc
     2101 tggcaaaggg aaattcagac gtgggcgtct cagatgaatg ctgtggttta tttaggtgac
     2161 attaacagca gaaacatgat aagaacgcac gaatggatgc atccccagac caaacggtta
     2221 aagtttaaca tacttttaac aacgtatgaa attttattga aggataaggc attccttggt
     2281 ggtctgaatt gggcatttat aggtgttgat gaagcacatc gattaaaaaa tgatgattcc
     2341 cttctatata aaactttaat tgatttcaaa tctaatcacc gcctcttaat cactggaact
     2401 cctctgcaga actccctgaa agagctctgg tcattgctgc atttcattat gccagaaaag
     2461 ttttcttcat gggaagattt tgaggaagaa catggtaaag gcagagaata tggttatgca
     2521 agcctccaca aggagcttga gccatttctg ttacgcagag ttaagaaaga tgtggaaaaa
     2581 tctcttcctg ccaaggtgga gcagatttta agaatggaaa tgagtgcttt acagaaacaa
     2641 tattacaagt ggattttaac taggaattac aaagccctca gcaaaggttc caagggcagt
     2701 acctcaggct ttttgaacat tatgatggag ctaaagaaat gttgtaacca ttgctacctc
     2761 attaaaccac cagataataa cgaattctat aataaacagg aggccttaca acacttaatc
     2821 cgtagtagtg gaaaattaat tcttctagac aagctgttga ttcgtctaag agaaagaggc
     2881 aatcgagtcc tcattttttc tcagatggtg cggatgttag atatacttgc agaatatttg
     2941 aagtatcgcc aattcccctt tcaaagatta gatggatcaa taaaagggga gctgaggaga
     3001 caagctctag accactttaa tgcggagggg tcagaggatt tctgcttttt gctctctacc
     3061 cgagctgggg gtttaggcat taacttagcc tctgctgaca ctgttgttat attcgattcg
     3121 gattggaatc cacaaaatga tcttcaggct caagctagag ctcatcgaat tgggcagaag
     3181 aaacaggtga atatatatcg cttggttaca aagggatccg ttgaagaaga tattcttgaa
     3241 agggccaaaa agaaaatggt cttggatcat cttgtgattc aacgaatgga taccactggg
     3301 aagacagtgt tgcacacagg ctccgctcca tcaagttcta cccccttcaa taaagaggaa
     3361 ttatcagcca ttttaaagtt tggtgctgag gagcttttta aggagcctga aggagaagag
     3421 caggagcccc aggagatgga tatagatgaa atcttgaaga gagctgagac tcacgaaaat
     3481 gagccaggcc cgctgactgt cggggatgag ctgctctccc agtttaaggt tgccaatttt
     3541 tcaaatatgg atgaagatga cattgaattg gaacctgaaa gaaattcaaa gaactgggag
     3601 gacatcattc cagaagagca aagacgacgg ttagaagagg aggagagaca aaaggagctg
     3661 gaagaaattt atatgctccc gagaatgaga aactgtgcaa agcagataag tttcaatgga
     3721 agtgaagggc ggcggagtag aagcagaaga tactcgggat ctgatagtga ttcaatctcg
     3781 gaaaggaagc ggccgaagaa acgtgggcga ccacgcacca tccctcggga gaacattaaa
     3841 ggctttagtg atgcggagat taggcggttt atcaagagct ataagaaatt tggtggccct
     3901 ctggagaggt tagatgcaat tgctcgagat gctgaattgg ttgataaatc ggaaacagac
     3961 ctcagaagac taggagaact ggtgcataat ggttgtgtta aagctttaaa agatagttct
     4021 tcgggaacag agcgagcagg tggcagactt ggaaaggtga aggggccaac gttccgaata
     4081 tccggagtac aggtgaatgc gaagctggtc attgctcacg aggacgagct gatacctttg
     4141 cataagtcca ttccctcaga cccggaggag aggaagcagt atacaatccc atgccataca
     4201 aaggctgctc acttcgatat agactggggc aaagaggatg actcgaattt attaattggt
     4261 atctatgaat atggctatgg aagctgggaa atgattaaaa tggatccaga cctcagctta
     4321 acacacaaga ttcttccaga tgatcctgat aaaaaaccac aagcaaaaca gttacagact
     4381 cgagcagact acctcatcaa actacttagc agagatcttg caaaaaaaga ggctcagagg
     4441 ctttctggtg cgggaggctc aaagaggaga aaaacaagag ctaaaaagaa taaagcaatg
     4501 aagtccatca aagtcaaaga ggaaataaag agtgactcat cgcccctgcc ttcagagagg
     4561 tctgaggagg aggacgataa cgtgaatgac tccaagcctg aaagtaaaga ccgctccaaa
     4621 aagtctgtgg tgtctgatgc tcccgtccac atcactgcaa gtggagagcc agtccccata
     4681 gctgaagagt ctgaagagct ggatcagaag acattcagta tttgtaaaga aagaatgaga
     4741 ccggtgaagg cagctttgaa acaacttgac aggcctgaga agggcctttc ggaaagagag
     4801 cagctggaac acactagaca gtgtttaatc aagatcggcg accatatcac tgaatgtttg
     4861 aaggagtatt ccaatcctga gcaaattaag cagtggagaa aaaacctgtg gatttttgtt
     4921 tctaagttta ctgaatttga tgcaaggaaa ttacataaat tatataagca tgctattaaa
     4981 aaacgacaag aatctcagca aaacagtgac cagaatagca atgttcctac cactcatgtg
     5041 attaggaatc cagacatgga aaggttaaaa gagaatacaa atcacgatga cagcagcagg
     5101 gacggctact cttcggacag acacttatct cagtgccatg atcatcacaa ggaccgccat
     5161 cagggagact cttataaaaa gagtgactct cggaagagac cctactcctc atttagcaac
     5221 ggcaaagacc atcgcgagtg ggatcactac aggcaagaca gtaggtacta tagtgacaga
     5281 gagaaacaca gaaaactgga tgaccacagg agtcgagagc acaggccaag tgtggaaggc
     5341 agcttaaagg acaggtgtca ttctgaccac cgatctcact cggaccatcg gatgcattca
     5401 gaccatcgct ccagcactga gcacacacac cataagtctt ccagggatta taggtacctc
     5461 tcagattggc agctggacca ccgagctgcc agcagtggcc ctaggtctcc tttagatcag
     5521 aggtctccat atggctccag gtccccattt gaacattcag ctgaacacag aagtacacct
     5581 gaacacacct ggagtagtcg gaagacataa cagatactga tggttttgtc tttctggact
     5641 tcattttagc catagatcat aaaccaacac agtaattgcc ttacatgact tgaaagatac
     5701 aaacagctct tctatctatc ggtagcagta ttgttacttc tttccaggac gcaaggtcta
     5761 ttatcccaac agaagagaag atatttttat atttaaggat tatgctgcac tgtactgcaa
     5821 tactgtagta cctttttttc tttttttaaa gaaatggaaa atgtttacta taccagggac
     5881 ctcagcactg ccctcccgtg taggctgtat aaaactgttt atacgtcagt gattttagac
     5941 tgactccatt taaattatgt ttgtatatga actttactct gacctgtgat catgtttcag
     6001 gaaggaatga aagagaggtc ttttcttaat aaagaaaaat cgctcaagga ctttgttcac
     6061 tttccaaagc tacttgttta cattgtacac tgcgaccacc ttgccgcttc ccgtcacaag
     6121 cttgaatatt taaatcctgt actgaagtct gtaagatagc cgggaacttc ctgtttgtga
     6181 ttattattat gcctttttac agaagaagat ggctgtaaat tattgtaaat gtataaatga
     6241 gctttccttc cttacccttc tcaggcttct tctgactgtt cctttcccta ccaactcagg
     6301 ccttcttatt aaaaaaaaaa aaatcagtgt aataacactc tttaatgatt tgtctcgatg
     6361 gaatcattgt ttagaatgta aaaatgggga aaggggccac ttattcattt cgtcctcttt
     6421 ttatattgaa tatttttgtt agatacatgt tttacccctc ctttttaaag tcaattttgt
     6481 gtttgtagtt tttacagaag aagaagtggt gagggttaca tgtgagatag aaacttgatg
     6541 ctctgggaaa gtttgcagat gcatttggtt taaaagggta ggtgtgtgaa cactttcaaa
     6601 atccagactg gccaaacgtt cttgtgagtc catttgtttt ccctctcacg tgggcaataa
     6661 tgtcaaatgt gctatgcagc caggctaaca ttttagacgg acttgattga ctttttaata
     6721 taaactgtta cagtgcacac tgattgtaca taaaacctta tatatgacaa attaaattct
     6781 aagaaaaagg atatgtgggc tcctggagtt tctgctgcat ccttgtttcc tcaagcattt
     6841 aatcttttgt tttaagtaac tgctgccaga aagaaaggtg ttttggtaaa caattggatt
     6901 gataatatga aatcctaagc tcttactgtg tggacgaatc cgtcttctgt gaagtagaac
     6961 agatgacaga agtcttggct tcctgtgggc attctccttg gatgccttac tcaaccaccc
     7021 ccttctcctt acactcagtg gggattttgt atgtatgttg tgtagccatg aataacgttt
     7081 actcctggtc tccatggggg caacctaaag ttagtctgtg gctttatatt tttatatctt
     7141 ccttttacat gattaaatat gaaatttatg ctgtgtatac aaacagactt ttcttttcaa
     7201 agcagtttca tctctggcct aaagttatcc cgaagcagac gatgtatttt tattcttgat
     7261 atgcaaggta atgcgttggg gaataactca acttttaaac atctagtttt aattaaagat
     7321 aaaaatgatg atagtatatt cagtgctggc acacaacttt taacattttt cactttcctc
     7381 cacttttaat gtaaacgatc atttaattcc caaagaacac ttcccacaat cctgatacac
     7441 agcaaatagc tcagggtcgg cgctacatgc ctttgcggct aagtcatttg cttaaaagcc
     7501 tgttgtagag actttgcgaa aaataatgca attttggaga atgggctggg ttttttttct
     7561 ttttttcttt ttaacaattt gacatttaat tgcattaact tgctgaggtg aatgaagcaa
     7621 tcttaaacct gtatgtaaca tttgagtgtt atttgtaaaa agtaacagtt acacagtaaa
     7681 ggagcaagcc ataaagttac tgagatacag ggacagcagc agtccggggc attacccaca
     7741 tgcttacttt tgtctcttac atgctcattc tgcttctctg tccacttgtt taccttttaa
     7801 agatgagaga ttacacatag cattgtacca actaaccttc cattttaata ataaacaata
     7861 aacgattctt ataaaaa
//
LOCUS       NM_001437328            1913 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 12 (Chst12),
            transcript variant 2, mRNA.
ACCESSION   NM_001437328 XM_017598322
VERSION     NM_001437328.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Prisco,S.Z., Prokop,J.W., Sarkis,A.B., Yeo,N.C., Hoffman,M.J.,
            Hansen,C.C., Jacob,H.J., Flister,M.J. and Lazar,J.
  TITLE     Refined mapping of a hypertension susceptibility locus on rat
            chromosome 12
  JOURNAL   Hypertension 64 (4), 883-890 (2014)
   PUBMED   25001272
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Hiraoka,N., Nakagawa,H., Ong,E., Akama,T.O., Fukuda,M.N. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of two distinct human chondroitin
            4-O-sulfotransferases that belong to the HNK-1 sulfotransferase
            gene family
  JOURNAL   J Biol Chem 275 (26), 20188-20196 (2000)
   PUBMED   10781601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2025 this sequence version replaced XM_017598322.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.40596.1,
                                           SRR26643284.15484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000012.1  19242868-19242930   c
            64-261              JAXUCZ010000012.1  19238461-19238658   c
            262-1913            JAXUCZ010000012.1  19224545-19226196   c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1913
                     /gene="Chst12"
                     /note="carbohydrate sulfotransferase 12"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
     exon            1..63
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     exon            64..261
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     exon            262..1913
                     /gene="Chst12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    306..308
                     /gene="Chst12"
                     /note="upstream in-frame stop codon"
     CDS             339..1598
                     /gene="Chst12"
                     /EC_number="2.8.2.5"
                     /note="carbohydrate (chondroitin 4) sulfotransferase 12"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 12"
                     /protein_id="NP_001424257.1"
                     /db_xref="GeneID:304322"
                     /db_xref="RGD:1308214"
                     /translation="MTKPRLFRLWLALGSALMILLIIVYWDNVGTAHFYLHTSLSRPH
                     ILEPLPTQGLAEENVLASDVDEFLDTLLSSDAKHNDLSRRKTEQPPVLTPSKPVLSHM
                     EENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELN
                     HLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTH
                     LTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFA
                     VPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLC
                     HPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLA
                     WRQQLYKLYEADFVLFGYPKPENLLRD"
     misc_feature    831..1571
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
     misc_feature    831..1571
                     /gene="Chst12"
                     /note="Sulfotransferase family; Region: Sulfotransfer_2;
                     pfam03567"
                     /db_xref="CDD:427369"
ORIGIN      
        1 agaatcagca gcctcagcaa cagcagcagc agcagcagcg gtggtgactg tagcgggcgc
       61 taggctcagc gctggcggaa aagagggagt agggacagga ggatcctggg gctcactggc
      121 caaccgttct gacaagatca gtgaattccg ggctcagtga gaaattccgt ctcaaaaaat
      181 aaaccagaga gggatcgagg aagacacctc ccttcaactg ctggccatca catgcacgtg
      241 cccaggcatg caaataaata cgtccctctc ccagcaccat gtcccagcgg tacacaaggc
      301 tgaagtgaag ggccaggtgt ggccctgccc agggcagcat gaccaagccg cggctcttcc
      361 ggctgtggct ggcactaggg tcggccctca tgattctttt gatcattgta tattgggaca
      421 acgtgggcac tgcccacttc tatctgcata cgtccctgtc caggccacac atcctagaac
      481 cccttcccac ccaggggctg gcagaggaga acgtgttggc ttccgatgtg gacgagtttt
      541 tggacacgct ccttagttct gacgcgaaac acaacgacct ttccaggaga aaaactgagc
      601 agcccccggt gctcaccccc agcaagccag tcttgagcca catggaggag aacgtgagag
      661 gctacgactg gtccacccat gatgcccagc agaacccaga ccgggacagg cagcaggccg
      721 agaggaggag cctgctgagg gatttctgtg ccaacgccag cctggcattc cccaccaagg
      781 accgctcttt tgacgacatc cccaactacg aactgaacca cctgattgtg gacgaccgcc
      841 acggggtcat ctactgctac gtgcccaagg tggcctgcac caactggaag cgagtgatga
      901 tcgtgctgag cgagagcctg ctggaccggg gcagccccta ccgagacccc ctggacatcc
      961 cccgggagca cgtgcacaac accagcacgc acctgacctt caacaagttc tggcgccgct
     1021 acgggaagtt ctcccgtcac ctcatgaagg tcaagctgaa gaagtacacc aagttcctgt
     1081 tcgtgcgcga ccccttcgtg cgcctcatct cagccttccg cagcaagttc gagctggaaa
     1141 acgaggagtt ttaccgcaag ttcgcggtgc ccatgctccg gctgtacgcc aaccacacca
     1201 gcctgcccgc ctcggtgagc gaggctttca gcgcaggcct caaggtctcc ttcgccaact
     1261 tcatccagta cctcctggac ccacacacgg agaagctggc gcccttcaac gagcactggc
     1321 gacaggtgta ccgcctctgc cacccgtgcc agatagacta cgacttcgtg gggaagctgg
     1381 agaccctgga tgaggatgct gcccagctcc tgaggtccct caaggtagac tcccaactcc
     1441 acttccctcc cagttaccgg aacaggaccg ccagcagctg ggaggaagac tggtttgcca
     1501 acatccccct ggcctggagg caacagctct ataaactcta cgaggccgac tttgttctct
     1561 ttggctaccc caagccagaa aacctgctca gggactgagc tcccataagc cctcacgctg
     1621 ccacaagaaa ctgagatggt cctttgagaa tgggaccccg tggcctcctg gttctctcct
     1681 ggcttcctgt accttccctg gtgtagacag gcagaggatg acacaaccca agcacctcac
     1741 tctccagagt ttcgcgcccc acccccaccc ccaccctttt gcaatctggg tttgtttact
     1801 ccacagcctg tactcatggg acactgtgtt aatactgttt tctacgatta atatatttca
     1861 gatatattta ataagaaagt gggaggaagc tggagtaaag tgtggagccc gca
//
LOCUS       NM_001437673            2430 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus spermatogenesis associated, serine-rich 2-like
            (Spats2l), transcript variant 1, mRNA.
ACCESSION   NM_001437673 XM_039083627
VERSION     NM_001437673.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2430)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 2430)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 8, 2025 this sequence version replaced XM_039083627.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.35385.1,
                                           SRR26643294.36368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000009.1  66815013-66815101
            90-139              JAXUCZ010000009.1  66839657-66839706
            140-224             JAXUCZ010000009.1  66873112-66873196
            225-285             JAXUCZ010000009.1  66898226-66898286
            286-394             JAXUCZ010000009.1  66921419-66921527
            395-444             JAXUCZ010000009.1  66924616-66924665
            445-691             JAXUCZ010000009.1  66927640-66927886
            692-898             JAXUCZ010000009.1  66942416-66942622
            899-1034            JAXUCZ010000009.1  66943912-66944047
            1035-1093           JAXUCZ010000009.1  66965594-66965652
            1094-1203           JAXUCZ010000009.1  66979059-66979168
            1204-1306           JAXUCZ010000009.1  66981573-66981675
            1307-1527           JAXUCZ010000009.1  66984115-66984335
            1528-2430           JAXUCZ010000009.1  66987182-66988084
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2430
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="spermatogenesis associated, serine-rich 2-like"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
     exon            1..89
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            90..139
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            140..224
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="upstream in-frame stop codon"
     CDS             187..1923
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SPATS2-like protein"
                     /codon_start=1
                     /product="SPATS2-like protein isoform 1"
                     /protein_id="NP_001424602.1"
                     /db_xref="GeneID:316426"
                     /db_xref="RGD:1309930"
                     /translation="MAGTQETGASTSKAYTPRRKMAELNTHVNVKEKIYAVRSVVPNK
                     SNNEIVLVLQQFDFNVDKAVQAFVDGSAIQVLKEWSMTGKKKNNKRKRSKSKQHQGNK
                     DAKDKGERPEVGPLQPQAPLVQNGHMNGCEKDSSSPDSAREKLALTPREKKISILEEP
                     PRAQRGITEGSRLLQQKMSLDGNPKAIHGPSERSDGLQWSAGQPCNPSKPKAKTSPVK
                     SNAPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAA
                     FAELHNCIIDKEVSLMAEMDKVKEEAMDILTARQKKAEELKRLTDLASQMAEMQLAEL
                     RAEIKHFVSERKYDEELGKAARFSCDIEQLKAQILICGEITHPKNNYSSRTPCSSLLP
                     LLNTHAVASGKQGNFSRKSSGHNKPNEGKAANPKMVSGLPSTADACQQTMPTNKQQNG
                     PSNQRRRFNPQYHNRLNGPAKSQGSGNEADPMVKSNNRHEHRRQPHNGFRPKNKGGAK
                     NQEAPLGTKAPEAPPHSEKARRRQHAADNLETRPFRGNVGRVSQCNLCPTRIEVSTEA
                     TVLSVPAVTLVA"
     misc_feature    421..1350
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     misc_feature    421..1350
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /note="Protein of unknown function (DUF1387); Region:
                     DUF1387; pfam07139"
                     /db_xref="CDD:462100"
     exon            225..285
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            286..394
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            395..444
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            445..691
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            692..898
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1034
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1093
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1203
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1306
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1527
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2430
                     /gene="Spats2l"
                     /gene_synonym="RGD1309930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgctctc cctccgctcg ccctccgcgc cgcaggggcc gccagcgctg cgccccggcc
       61 cgggacagag cggccgcact cgcaccgagg agactccaga agccaggctg ctttcgggaa
      121 caactctgtg gattcccagg tcctgtggtc agagctgaag gccccggtta gtcccgctgc
      181 aagtacatgg ctggaacaca ggaaaccgga gcttcaacga gcaaggctta tacccctaga
      241 aggaagatgg ctgaactcaa cactcatgtg aatgtcaaag agaagatcta cgcagttaga
      301 tcagttgttc cgaacaaaag caataatgaa attgtcctgg tgctccaaca gtttgatttt
      361 aatgtggata aagccgtgca agcctttgtg gacggcagtg ctattcaggt tcttaaagaa
      421 tggagcatga cggggaaaaa gaagaataac aaaagaaaaa gaagcaaatc caagcagcat
      481 caaggcaaca aagatgctaa ggacaagggg gagaggccgg aggtggggcc cctgcagccc
      541 caggcaccac tggtacaaaa tggtcacatg aatggctgtg aaaaggacag ctcatcccct
      601 gactctgcca gagaaaaact ggccctcaca ccacgtgaga aaaagatctc aatactggag
      661 gaaccaccaa gggctcagcg tgggatcaca gaaggcagca gactactgca gcagaaaatg
      721 tccttagatg ggaaccccaa agctattcat ggaccatcag agaggtcaga tggcctacag
      781 tggtcagctg ggcagccttg taacccaagc aagcctaagg caaaaacatc tcctgttaag
      841 tccaatgccc ctgcagctca tcttgaaata aagccagatg agctggcaaa gaaaagaggt
      901 ccaaatattg agaaatcggt gaaggatctg cagcgctgca ctgtttctct gacgagatac
      961 cgagtcatga tcaaggaaga ggtggacagt tctgtgaaga agatcaaagc agcttttgct
     1021 gagctacaca actgcatcat tgacaaagaa gtttcactga tggcagagat ggataaagtt
     1081 aaagaagaag ccatggacat cctgactgcc cgtcagaaga aggcagagga gctgaagcga
     1141 ctgactgatc tagccagtca aatggcagag atgcagctgg ccgaactcag agctgaaatt
     1201 aagcactttg tcagcgaacg caaatatgat gaagagctag ggaaagccgc ccgcttctcc
     1261 tgcgacattg aacagctgaa agcccaaatc ctgatctgcg gagaaatcac acatccaaag
     1321 aacaactatt cctcaagaac tccctgcagc tccctgttgc ctctgctgaa cactcatgcg
     1381 gtagcttccg ggaagcaggg gaatttttcc cggaagtcat ccggtcacaa caagcccaat
     1441 gaggggaaag cagcgaaccc caaaatggtg agcggtcttc ccagcactgc cgatgcatgt
     1501 cagcagacca tgcctactaa caagcagcag aatggacctt ccaaccaaag acgaagattt
     1561 aatccacagt atcacaacag gctaaatggt ccagccaagt cacagggcag tggtaatgaa
     1621 gctgatccca tggtgaagag caacaaccga catgaacaca gaagacagcc acataatggt
     1681 tttcgtccca aaaacaaagg tggtgccaaa aaccaagagg cccccttggg gacaaaggcc
     1741 ccagaggccc caccacattc tgaaaaggcc cgtcgaaggc agcacgctgc agacaactta
     1801 gagaccaggc ctttccgggg taatgttggt agggtttcac agtgcaatct ttgtcccact
     1861 agaatagaag tttccacaga ggccacggtt ctctcagtcc cagctgtgac gctggtggcc
     1921 tgagctggga aggaagagag caggttttgc ctggttttgg ttccctgccc aaggtgctga
     1981 cccaattcgc tgccaaaaga gagtcaatca gaatatacaa acctgtatgt ttgtgtcgtt
     2041 ctctcgcaat catttttact aatcctagta ctctgctcta gcttgcttca taactcccat
     2101 ggctttgctt gatctgttgt cgcttctcct catcaagact ttgcatcatg ttagccagcc
     2161 agtatttacc cattgttagg aaaatcgaga tgtggctgaa gatcagaggc tcagttagca
     2221 acctacgttg tagctgtgat gtcgacccat tggttgtctt tagagagtta atgttgaaac
     2281 aagaaattct tgatcagaca aacgtgatct gctgaagaca catgtgcttt tgtagaattt
     2341 aacatctggt gtttttctga aatattatat aaatatatat ataaacatat attgctttat
     2401 ttgaaacaaa ttaaaatatg ctgcatttga
//
LOCUS       NM_001437295             781 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S6 (Mrps6),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437295
VERSION     NM_001437295.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI282247.1, SRR22582416.1563961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000011.1  44781554-44781703
            151-290             JAXUCZ010000011.1  44823304-44823443
            291-781             JAXUCZ010000011.1  44833930-44834420
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..781
                     /gene="Mrps6"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
     exon            1..150
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..483
                     /gene="Mrps6"
                     /note="isoform 1 is encoded by transcript variant 2; 28S
                     ribosomal protein S6, mitochondrial; small ribosomal
                     subunit protein bS6m"
                     /codon_start=1
                     /product="mitochondrial ribosomal protein S6 isoform 1"
                     /protein_id="NP_001424224.1"
                     /db_xref="GeneID:100360017"
                     /db_xref="RGD:2322928"
                     /translation="MPRYELALILKAMRRPETAAALKRTIESLMDRGAIVRNLENLGE
                     RALPYRISSHSQQHSRGGYFLVDFYAPTNAVESMLEHLARDTDVVRPNIVKHPLTQEV
                     KECDGIVPVPLEEKLYSTKRRKK"
     misc_feature    112..393
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    112..393
                     /gene="Mrps6"
                     /note="Mitochondrial Ribosomal Protein (MRP) S6; Region:
                     bS6_mito; cd15465"
                     /db_xref="CDD:275386"
     misc_feature    order(115..117,250..252,262..264,319..321,328..333,
                     352..354,373..375,382..390)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(115..117,250..252,262..264,319..321,328..333,
                     352..354,373..375,382..390)
                     /gene="Mrps6"
                     /note="rRNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(118..120,124..126,238..240,244..252,292..294,
                     298..300,373..375,385..387)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     misc_feature    order(118..120,124..126,238..240,244..252,292..294,
                     298..300,373..375,385..387)
                     /gene="Mrps6"
                     /note="S18 interface [polypeptide binding]; other site"
                     /db_xref="CDD:275386"
     exon            151..290
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
     exon            291..781
                     /gene="Mrps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttcgccg ccagggagcc taccggctgc atctcctctc gtcttccact gcacccggcg
       61 tttcccgacc tagcgacccc ggactcggtg ccgccatccc gggcgatgcc ccgctacgag
      121 ttggctttga ttctgaaagc catgcggcgg ccagagaccg ctgctgcttt aaaacgtaca
      181 atagaatccc tgatggaccg aggagccata gtgaggaact tggaaaacct gggtgagcgt
      241 gcactcccat acaggatctc cagtcacagc cagcagcaca gccgaggagg gtatttcttg
      301 gtggattttt atgccccaac aaatgctgtg gaaagcatgc tggaacactt ggcacgagac
      361 actgatgtgg ttagaccaaa tattgtgaaa caccctctga cccaggaagt aaaagagtgt
      421 gacggcatag tcccagtccc tcttgaagaa aaactgtatt caacaaagag aaggaagaag
      481 tgagaagatt caccagatgt ggctatgttc aattctaagt gcaccatggg tgctgatagg
      541 tttgtctagg atgctttagc ccgtgaccat tttgctgcag atggggactg ctggccgaga
      601 cctgctctgt cacccctgct gatatttcac cctcactgtg tgattgtcag ggtgcggtgg
      661 ggctggtgtt cacagtccca ctgcagagtt tcgaagaaca aaatgtttgt cattcacact
      721 cggttgtctt gtaaacctgt gtggaacaca gagcagagta ataaacatgg ttttatcaac
      781 a
//
LOCUS       NM_001437309            5312 bp    mRNA    linear   ROD 10-APR-2025
DEFINITION  Rattus norvegicus KIAA1328 homolog (Kiaa1328), transcript variant
            3, mRNA.
ACCESSION   NM_001437309
VERSION     NM_001437309.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1322829.1,
                                           SRR26643293.76442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000018.1  16764588-16764666
            80-115              JAXUCZ010000018.1  16770797-16770832
            116-258             JAXUCZ010000018.1  16771469-16771611
            259-353             JAXUCZ010000018.1  16776653-16776747
            354-469             JAXUCZ010000018.1  16794966-16795081
            470-597             JAXUCZ010000018.1  16865059-16865186
            598-1271            JAXUCZ010000018.1  16920208-16920881
            1272-1355           JAXUCZ010000018.1  16927043-16927126
            1356-1537           JAXUCZ010000018.1  16983935-16984116
            1538-1646           JAXUCZ010000018.1  16996889-16996997
            1647-5312           JAXUCZ010000018.1  17047419-17051084
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5312
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="KIAA1328 homolog"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
     exon            1..79
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1851
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="protein hinderin isoform 3"
                     /protein_id="NP_001424238.1"
                     /db_xref="GeneID:498831"
                     /db_xref="RGD:1562608"
                     /translation="MAGAAGPSLPGSAFWSRDFSDEEQSVVYVPGISTERNTRSRLKL
                     INPKVDAKVKVPKVTDIPASMESLKGAGDSVAEQSFCKRGLKSASLKDLCVEDKRRIA
                     NLIKELARVSEEKEVTEERLKTEQESFEKKIRQLEEQNELIIKEREALQLQYRECQEL
                     LSLYQKYLSEQQEKLTMSLSELGAARAQEQQITKKKITHQSSLVNLDGSYLSVAKPQT
                     CQTRARPKSENQDSASESHTALRNNSLKPVTLHHPKQDLERMSTETRTCTYESPGRRL
                     INAAPVEEALPEELKIKDYPNLLPTPSSQYCGHKYSESEAYVHENYHPTNMASQCCKT
                     HPESCSHCRMSWASLMHDGVTLQPRETDIEKQLSEDRRQQLMLQKMELEIEKERLQQL
                     LAQQETKLLLKQQQLHQSRLDYNWLRTQAVFRSRELVADKDFPKPGSDSGPSLLKPKC
                     DGWLRGTSSSFRKCPDSPNSAQNQKEKKTVEFQSHVENGIQWTCQQNDTCRLQRETAT
                     GVRKDASTSPMSTQSPKHPLTPASSSSKHKTSRYETSLLDLVQSLSPNSAPKCQPHSS
                     RAAGTWSALRPTPKTSTWKKVGTHKSPEDLEENQILEDIFFI"
     misc_feature    298..1269
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     misc_feature    298..1269
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /note="Uncharacterized protein KIAA1328; Region: KIAA1328;
                     pfam15369"
                     /db_xref="CDD:464679"
     exon            80..115
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            116..258
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            259..353
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            354..469
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            470..597
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1271
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1355
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1537
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1646
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..5312
                     /gene="Kiaa1328"
                     /gene_synonym="RGD1562608; RGD1564140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcgagtg gcggttgttt caagatggcg ggcgcggcgg gcccctccct gccgggctcc
       61 gcgttctgga gccgcgactt ttctgatgaa gaacaatccg tagtttatgt tccaggaatc
      121 tccacagaaa gaaatacaag atcaaggctc aagttgataa atccaaaagt tgatgctaaa
      181 gttaaggttc ccaaggtgac tgatattcct gcctccatgg agtctttaaa aggtgcagga
      241 gattcagtag ctgaacagag tttctgcaag agaggactga agagtgcgtc attgaaagat
      301 ttatgtgttg aggacaaaag gcgcattgcc aatttaatta aagaactggc cagagtaagt
      361 gaagaaaagg aggtgacaga ggagcgactg aaaactgagc aggagtcctt tgagaagaag
      421 atccggcagt tggaggaaca gaatgaactg atcatcaaag aaagggaagc tcttcagcta
      481 cagtatagag aatgtcaaga acttctaagt ctctaccaga agtacctgtc agagcagcaa
      541 gagaagctta ccatgtcgct ctcagagctt ggagctgcta gagcacagga acagcagata
      601 accaagaaga aaatcactca ccagtcttca ttggtgaacc tggatggttc ctatctgagt
      661 gtagccaaac cgcaaacctg ccagaccagg gccaggccta agtcagaaaa ccaggactca
      721 gcttcagaat cccacacagc attaaggaat aattctttga aaccagtaac acttcatcat
      781 cccaaacagg atttagagag gatgtcaaca gaaaccagaa cgtgtactta tgaatctcca
      841 gggaggagac taataaatgc agccccagta gaggaagctc tcccagaaga gttgaagata
      901 aaggactatc caaaccttct gcctactcca tctagtcagt actgtggtca taaatactct
      961 gaaagtgaag cttatgttca tgagaactat catcctacga acatggcctc tcagtgttgt
     1021 aagacacatc cagaatcatg cagtcattgt aggatgtcct gggcatctct catgcatgat
     1081 ggagtgacac tgcaacccag agaaaccgac atcgaaaaac aactctcaga agatcgaagg
     1141 cagcagctga tgcttcagaa aatggaactg gaaattgaaa aggaacgcct tcagcaactc
     1201 ctggcccaac aagagacaaa gcttctcctt aaacagcagc agctgcacca atcccgacta
     1261 gattacaatt ggttaagaac tcaagctgtg tttagatctc gagaactggt tgctgataaa
     1321 gactttccta aacctggaag tgactctgga ccaagtttat tgaagccgaa atgtgatgga
     1381 tggctgcgtg gaacctcatc gtccttcaga aagtgcccag actctccaaa cagtgcgcaa
     1441 aaccagaagg agaagaaaac tgttgagttt cagtcacacg tggagaatgg cattcaatgg
     1501 acatgtcaac agaatgacac atgcagactc cagagagaga cagcaactgg agttagaaaa
     1561 gatgcttcca catctcctat gtcaacacaa agccctaaac accccctgac accagcctca
     1621 tcgtcatcca agcacaaaac ctcaaggtat gagacatctc tgttggactt ggttcagtct
     1681 ctgagcccaa attctgctcc taaatgtcag ccccattcct ccagagcagc agggacatgg
     1741 agtgctctcc gacctacccc taagacatct acctggaaga aagtggggac acataagagc
     1801 cctgaggacc tggaggagaa tcagattctg gaagacatat ttttcatatg actctgaagc
     1861 acatgctaca gaatttccac aggaaatatt tgagtttctt tccatattga tgtaggatgt
     1921 taaactgaaa agaagccgtg tctctccttt cgtggagacc tcttgctggc atccttttat
     1981 agtattgaat atagaaagca ttcttataaa tcagggtggt ttttgtcaga ccagttagca
     2041 gaaacagact aaagggggtc acttagaggt aggatctttt ctataccaaa cagaaattag
     2101 aaattgtgga tactgcctgc atagtaaaac ccatgaatgt ctagtgtcat tttaagagtg
     2161 ttttcaattt actactgcaa aaagttgact ctttacagat ggaaaacgtt cccattgaca
     2221 gaccccttaa atatgaaagt agccacttca gaaaggctct tctctcctca ccaatgctaa
     2281 gtgtggcgct tcattccgac gttgaagttg gtgactctaa tatcatctta catgggacca
     2341 atacttgtgg gtcatagtgg tcaaccgagt cattgccacc ccttaaacca aaaggctgaa
     2401 tgacttagag ggaagtttgc aaccagacag tggcattaga ccacatgagg gcatggccgc
     2461 ctggggaaat ttaccagtgt ccaggcagcc acctctccag tgttccatga tgggtgtttc
     2521 ttgtcgactt cagtgttgta aactttacct gtggttgtgt ctgaggaaga tagcactaga
     2581 ggaagagtgg tgtcgagtgg ctgcaggctg gcaggttcct tctgccccac ctcacaccat
     2641 aggacgagta tcctcctctg agcaccgtgg atgcagagtc tgagaacgct ctgctgatta
     2701 cccttcttgg cccagatcta gatcttttct cctcaggctg agctcagtgc tgttggttct
     2761 actcaggctc cctcccaagc tcatactctt cctctgaagc agctgcaagg gcaagactaa
     2821 ttaccctttg gaaatttaaa gttcattgaa aattccaatt ttcttttcaa attcagcctg
     2881 agagtaacta gaacagactt gttctacttc aaaacacctt taggatatgc ctttggaggg
     2941 gcagaaatag ccatattctc agttgggttt ccagaaacat cttttctcta tcttgtgtca
     3001 aagacagctt aactatacct atttctttac acctgctata accatagtca ccgttctgag
     3061 catcagtagt cttactactc ctgtatatct ccagaaggaa aagaaagaga atctgatctc
     3121 cttaagaagc ttatttacag gtagaagagt tgtaaacggc ctaaaaatga aagcttttgt
     3181 gcagtgacat gccagtgaat agaatttaat tgcttcttca ccagcatggg aagtttggaa
     3241 gagaaaaaag gggggttttc agtcagtaca ctttttatac ttcacagatc tgccatgcgt
     3301 taccttcttc tcatgcatat acatacatac atacacacac acacacacac acacggatat
     3361 atatatatat atatatatat atatatatat atatatatat atcctagtga ctttgttatt
     3421 aaccaaatag tatattgtgg cccatcccac agaagaatgg gaagaaagta ggagccatgt
     3481 gcctccctgg ataatgctct cttcggtggt tggttgggac ttgcttggcc agctcctaga
     3541 tgtttcctcc aagcaaaact gcactcaatg ataaaaattt agtttaacaa gattcaccaa
     3601 ggtcaccaga tagtaaggag caattcaaac ccagaggtga agatgggggg aaggggagtc
     3661 attgttcttt tctttacttc tctttcctat tttgagtaaa tatcaaaacc atcaagacca
     3721 ttttctacag tccagttatt atttatcaga cacatggatt ggtaaggaga ggagagcagt
     3781 gggaagaagg gattaaagga aacaggccta catccctttg cagccttggt acaattcctt
     3841 attgcatgca gttctctcat aaaggagaag aggaccagaa gagagaaatg gagatggtgg
     3901 gctctgggac ccttccactg ctccttcctc agtgccttat ctgcagtgtt taatgttttt
     3961 cttccaaatt taagatttct aactctcata cttggaaata caaagaactc cccagggctt
     4021 acaggtcaag gggcacaggc cctagagagg cacatcaggg ctctctgtct ccagccccat
     4081 gtccctttgc tgcatcagcc gcctccatta ccctcttctt tgctccccat tgcagctcac
     4141 cactgttaga cacatcccaa tggcacactt ctcttcccag gtccttctgg gtgaataact
     4201 taagactaag tttttaccac tttgtgaaat tttccttatg ttcctggcac tgtgtactgt
     4261 tgactccagt aagatgtgca gatatgtcca acccataagc cataagctgt gacgtatggt
     4321 caaggatagc tgtgaatgtg gcccaacaca aaattgtaaa cgtaagacat tttgagtagt
     4381 gtggttattt ttgtttttca cttttgtgtg tgtgacttga ttgtgcagct ctcaaacatg
     4441 aacattgtat ataataaatc atgtcatcat gttgctgtgt caaaggctgg ccatgcggca
     4501 agtccaagcc tctgtggtgg ccctcctcgt catgccacat tgtactgggt actgtttgcc
     4561 tttcttgtta gagttccagg tgtccagact aacatatgct atgtcggaga agccaagttc
     4621 accatttgta acatacagac atgcaggtga gttattgata ccttcagata atgataattc
     4681 tacctgcagt tttaggcctt atctgctgac ctagccctaa aagcctagac cagagaaaag
     4741 ctagaatgag aaggtcaaag ttcccaagaa tgtgaagctg acagttgggg ggcactgaga
     4801 cccatctcct tagaacatgg ggcaaccaac agacccaaag gcagggagca gagtcagtgt
     4861 tagaacagta cagagctggt tgaccagaac agtttcattc cagagctgac acccctctgc
     4921 cctctgtggt ctgacacctg attggctcat gccaagcaag cactagcaca aacattgccc
     4981 acagtgactc ccacccagaa gctccctctt tctcttcccc agatgctgcc ccacactctc
     5041 ctccacactc tttccagctc taggtcctaa ggtggccagg aggctgctga gatgagggag
     5101 accatgctgt atcccaggga aatggggtga gcccttagtt ttcaaacctc ctctgagaga
     5161 ttttaacttg ttggatttat gtagcattgg aaaatgataa actgtatgaa ttttctgtat
     5221 tttccatgga cagttattta tggaggggcg tttttaactc aagtgctaga aatgttaaat
     5281 catcataata aattcatgct attcagactt tc
//
LOCUS       NM_001437785            2684 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RAB3A interacting protein (Rab3ip), transcript
            variant 2, mRNA.
ACCESSION   NM_001437785
VERSION     NM_001437785.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Vetter,M., Stehle,R., Basquin,C. and Lorentzen,E.
  TITLE     Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3
            and Rabin8 effectors to Rab11
  JOURNAL   Nat Struct Mol Biol 22 (9), 695-702 (2015)
   PUBMED   26258637
REFERENCE   2  (bases 1 to 2684)
  AUTHORS   Klip,A., Sun,Y., Chiu,T.T. and Foley,K.P.
  TITLE     Signal transduction meets vesicle traffic: the software and
            hardware of GLUT4 translocation
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C879-C886 (2014)
   PUBMED   24598362
  REMARK    Review article
REFERENCE   3  (bases 1 to 2684)
  AUTHORS   Chiba,S., Amagai,Y., Homma,Y., Fukuda,M. and Mizuno,K.
  TITLE     NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by
            switching binding specificity from phosphatidylserine to Sec15
  JOURNAL   EMBO J 32 (6), 874-885 (2013)
   PUBMED   23435566
REFERENCE   4  (bases 1 to 2684)
  AUTHORS   Blumer,J., Rey,J., Dehmelt,L., Mazel,T., Wu,Y.W., Bastiaens,P.,
            Goody,R.S. and Itzen,A.
  TITLE     RabGEFs are a major determinant for specific Rab membrane targeting
  JOURNAL   J Cell Biol 200 (3), 287-300 (2013)
   PUBMED   23382462
REFERENCE   5  (bases 1 to 2684)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   6  (bases 1 to 2684)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   7  (bases 1 to 2684)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
REFERENCE   8  (bases 1 to 2684)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   9  (bases 1 to 2684)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   10 (bases 1 to 2684)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001437785.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.39114.1,
                                           SRR26643287.17902.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000007.1  54461114-54461277   c
            165-444             JAXUCZ010000007.1  54446719-54446998   c
            445-703             JAXUCZ010000007.1  54444976-54445234   c
            704-781             JAXUCZ010000007.1  54428642-54428719   c
            782-985             JAXUCZ010000007.1  54427855-54428058   c
            986-1114            JAXUCZ010000007.1  54425796-54425924   c
            1115-1227           JAXUCZ010000007.1  54424518-54424630   c
            1228-1327           JAXUCZ010000007.1  54420776-54420875   c
            1328-1397           JAXUCZ010000007.1  54420625-54420694   c
            1398-2684           JAXUCZ010000007.1  54417418-54418704   c
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2684
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="RAB3A interacting protein"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
     exon            1..164
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            165..444
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="upstream in-frame stop codon"
     CDS             194..1480
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rab-3A-interacting protein; rabin-3; SSX2-interacting
                     protein; rab3A-interacting protein"
                     /codon_start=1
                     /product="rab-3A-interacting protein isoform 2"
                     /protein_id="NP_001424714.2"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
                     /translation="MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPH
                     PSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGL
                     TRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYER
                     LKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTS
                     PTQEPLAAGKTPFKRGHTRNKSTSSAMSGSHQDFSAIQPIVKDCREADLSLYNEFRSW
                     KDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVLEAVENNTLSIEPVGLQPIRFV
                     KASAVECGGPKKCALTGQSKPCKHRIKLGDSSSYYYISPVCRYRITSVCNFFTYIRYI
                     QQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL"
     misc_feature    500..>820
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Autophagy protein 16 (ATG16); Region: ATG16;
                     pfam08614"
                     /db_xref="CDD:462536"
     misc_feature    500..>820
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Autophagy protein 16 (ATG16); Region: ATG16;
                     pfam08614"
                     /db_xref="CDD:462536"
     misc_feature    <665..>817
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; Region:
                     CwlO1; COG3883"
                     /db_xref="CDD:443091"
     misc_feature    <665..>817
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; Region:
                     CwlO1; COG3883"
                     /db_xref="CDD:443091"
     misc_feature    893..1471
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    893..1471
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    order(1148..1168,1331..1333,1340..1345,1352..1354,
                     1364..1366,1379..1393)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     misc_feature    order(1148..1168,1331..1333,1340..1345,1352..1354,
                     1364..1366,1379..1393)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     exon            445..703
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..781
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..985
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1114
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1227
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1327
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1397
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..2684
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggctct ccctccctcg gctcccatcg cagtgcgccc gccgcggcgg agtggagcgg
       61 cgtctgtccg ccgccgtcct tcgcgtctcc cgagctgggc acgcgcaccc tgcggctctg
      121 cgagcgccgc tgagcgcggg cggcggccgc ggcgggtccg gcagcttagg ctgtcctatg
      181 atgaagtctt gctatggcta acgacccctt agaaggtttc catgaagtga acctcgcttc
      241 gcctacctct ccagaccttc ttggtgtgtg tgacccggga acccaagagc agactacctc
      301 cccgagcgtc atctaccggc cacacccttc gacgttgtgc tctgccacta tccaggccaa
      361 tgccttaaat ctttctgacc ttcccacaca gcctgtgtat tcatccccga ggcatttaaa
      421 ctgtgcagaa atatctaaca tcagcattca tgttccagag ccagcatcat cggtagcctc
      481 tgaggtggca gcagggctca cgaggttcac ctcaaggaag gacagctgca acgcagagag
      541 ggagtttctg cagggcgcca ccgtcacaga ggcttctgct ggcaacgatg acatctttgg
      601 gttgagcacg gacagcctgt cccgtttacg gagcccatct gttctggaag ttagagagaa
      661 gggctacgaa aggttaaaag aagaacttgc aaaagctcag agggaagctc acaagatggt
      721 gagagaggcg aacgtcaagc aggcaactgc agaaaagcag ctgaaggaag ctcaagggaa
      781 aattgatgtg cttcaagccg aagtggctgc gctgaagaca ctcgtactgt ccagttctcc
      841 aacatcgcct acgcaggagc ctctggcggc tggaaagacg ccctttaaaa gggggcacac
      901 acggaacaaa agtacaagca gtgctatgag tggcagccac caggacttca gtgcgatcca
      961 gccaatcgta aaagactgca gagaggccga tctatcgctg tataatgagt tcaggtcttg
     1021 gaaggatgag cccacaatgg acagaacatg tcccttccta gacaaaatct atcaggagga
     1081 tatctttcca tgcttaacat tcgcgaaaag tgagttggct tcagctgttc tggaggccgt
     1141 ggagaacaac actctaagca tcgagccggt agggttgcag cccatccgct tcgtgaaggc
     1201 ttccgcggtg gagtgcggag ggccaaaaaa gtgtgctctc actggccaga gtaagccctg
     1261 taagcacagg attaaactag gggactccag cagctattac tacatctctc cggtttgcag
     1321 ataccggatc acttctgtat gtaacttttt tacatacatt cgatatattc agcagggact
     1381 tgtgaaacag caggatgttg atcagatgtt ctgggaagtt atgcaactaa gaaaggagat
     1441 gtcgttggca aagctgggat atttcaaaga agaactctga tgccctgagt acggggccgt
     1501 gcgtgctcct ccctggacag ctgaaggatg acaacgtttt tatggttact caatatttat
     1561 ttctaaggag aaggccaaag acttccctcc tctgcacacc acactatgaa gtgctgtgat
     1621 ttttttcaaa ctgactgagc tgtacttgct tatcccttaa tggaacacac tctgaagatt
     1681 gcaggcctgc tagtgatggt aattcaacac tgcaaatcca gaccaccaaa taaacaccag
     1741 actgaacatg tgtgtctttc ttagctctga ctcggcataa agttgcagag gttgatagta
     1801 gtcttcacat tgtacccctg tgagagcgag gaaggagcca gctggacagg gcttcatgtc
     1861 tgtgtgtatg ctggcattca gacgaaaggt tttatttatt tttattctgc cagctgtgat
     1921 gtagggaatc cttttatcat aatgatttgt taagtgtaat aaatgaagac agtgaacatt
     1981 cttgggcatc ctgacggagg gcttcacgtt agcattgagc attatcgtgg aatagaagga
     2041 gtgttaagtt taatagacca gggcatggcc taaaaggata cggtctgcca gctctgagct
     2101 tctggtgact gcttcatttc taaggttgga ctaatgctga cactcgggaa gaaacgacca
     2161 acatcagatg tacaaataaa agaggttcgt agtggagaca tagtatagga aagcaaagga
     2221 aaacagcccg cttccttaac tcgagtaaga acactccgct cacacttttg gagaacacct
     2281 tggactgtga aatatttcct acttatagat gcacaattct gattgttgta tgtgtgtgaa
     2341 tgtgtgtgtg tgtgcatctc acttgggcct tgtgcacaca gatctggaac tggagttgca
     2401 gacagccgtg agctgccgtc tctccagctt gtccctctcg ctttaaaagt aaataatttt
     2461 tctacattgt atgtgtctat gagggtgtac ctgtgtgtgt gtggcagtca gatgacggct
     2521 tttaggagtc tgttctctcc tgtctaggtt ttcatgatca aacagactca ggacatcagg
     2581 gttggtagca atacctttat gtgctgagcc atttctctgg tgcggatctc cacatcctaa
     2641 tcattgtgta ttcatcgcaa ttaaacatag tctaattgtc tcta
//
LOCUS       NM_001437952            1163 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus golgin A6 family like 9 (Golga6l9), transcript
            variant 2, mRNA.
ACCESSION   NM_001437952 XM_063274168
VERSION     NM_001437952.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063274168.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.458732.1,
                                           SRR26360181.708876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000015.1  78875208-78875292
            86-1163             JAXUCZ010000015.1  78875664-78876741
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..1163
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="golgin A6 family like 9"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
     exon            1..85
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     exon            86..1163
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    142..144
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="upstream in-frame stop codon"
     CDS             196..1020
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="spermatid associated like"
                     /codon_start=1
                     /product="uncharacterized protein LOC290425"
                     /protein_id="NP_001424881.1"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
                     /translation="MNISGSKQIHKRKILRLFSCFSCTQNQKKLKHKSQDVEKKLCRE
                     NKVLRDENRALRKDNKFLWGENKALGRENKTFRMDNQFIRERNHILRQQNQLLRKVKR
                     LISENPKLSGEECNALNTEGRSFWQQNRAMEAQITALRQQEKAFQNEAKALHEEIKSL
                     CEETKALQHQERALRMEEKALLRDGVAAELAEALTKEGAALEMEEQALWKEEQALREE
                     NKALREEHGALQDEEVALQEEARILQEWNNLLQGKITNNLPENMNNQDPEKCELRM"
     misc_feature    <337..>948
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <337..>948
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <661..>960
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
     misc_feature    <661..>960
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
ORIGIN      
        1 agaaaccagg ctacaagtga cttagagaac acagcaatgt aagtctggct ggttgcctca
       61 atctttaacc ctcctagaac gctaacgggc ctgtctgagc attgtggtcc attaagaagt
      121 caacagacag ccaagactac atgaacaaat ttagtacatt ttctgttgag attatcagta
      181 gtgcaccgaa aaacaatgaa tatctctgga tcaaaacaaa tacacaaaag gaaaatactg
      241 cggttgtttt cttgtttctc ttgtacccaa aatcaaaaga aactcaaaca taaatcccag
      301 gacgtggaaa aaaaactctg tagagaaaat aaggtgttga gagatgaaaa tagggctctg
      361 agaaaagaca acaaatttct ctggggcgaa aacaaagcct taggaagaga aaataaaacc
      421 ttccggatgg acaaccagtt catcagggaa agaaatcata tcctaaggca gcagaaccag
      481 ctactccgga aggtgaaaag gttgatttca gagaacccaa aactgtctgg ggaagaatgc
      541 aatgccttga acacagaagg aaggtctttt tggcaacaga atcgagccat ggaagctcag
      601 atcacagctc tccggcagca agagaaagcc ttccagaatg aggccaaagc cttgcatgag
      661 gagatcaagt ccctgtgtga ggagaccaag gctctacaac accaagagag ggctctcagg
      721 atggaagaga aagccctgct gagggacgga gtggctgcag agctggcaga ggccctgacc
      781 aaggagggag ctgctctaga gatggaagaa caggctttgt ggaaggaaga gcaggctctc
      841 agggaggaga acaaggcgct gagagaagag cacggggctc tacaagacga ggaagttgcc
      901 ctgcaggaag aggcgagaat cctccaggag tggaataatc ttcttcaggg gaagatcaca
      961 aacaacctcc cagagaatat gaataaccaa gacccagaga agtgcgaact aagaatgtaa
     1021 ccatgaagtc atgacaataa ttgtaattcc agaacataaa agtagaattc gatcgcgtaa
     1081 tgttattgtc agaagcctca gaaattgacg tgctcaatat ttggtccttg aaacaaaata
     1141 aaggcctgag aaataaatta aaa
//
LOCUS       NM_001108073            2978 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus tight junction protein 3 (Tjp3), transcript
            variant 3, mRNA.
ACCESSION   NM_001108073 XM_001069839 XM_234924
VERSION     NM_001108073.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Qiao,X., Roth,I., Feraille,E. and Hasler,U.
  TITLE     Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney
            collecting duct principal cell proliferation and adhesion
  JOURNAL   Cell Cycle 13 (19), 3059-3075 (2014)
   PUBMED   25486565
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Capaldo,C.T., Koch,S., Kwon,M., Laur,O., Parkos,C.A. and Nusrat,A.
  TITLE     Tight function zonula occludens-3 regulates cyclin D1-dependent
            cell proliferation
  JOURNAL   Mol Biol Cell 22 (10), 1677-1685 (2011)
   PUBMED   21411630
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Aho,S., Lupo,J., Coly,P.A., Sabine,A., Castellazzi,M., Morand,P.,
            Sergeant,A., Manet,E., Boyer,V. and Gruffat,H.
  TITLE     Characterization of the ubinuclein protein as a new member of the
            nuclear and adhesion complex components (NACos)
  JOURNAL   Biol Cell 101 (6), 319-334 (2009)
   PUBMED   18823282
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Adachi,M., Inoko,A., Hata,M., Furuse,K., Umeda,K., Itoh,M. and
            Tsukita,S.
  TITLE     Normal establishment of epithelial tight junctions in mice and
            cultured cells lacking expression of ZO-3, a tight-junction MAGUK
            protein
  JOURNAL   Mol Cell Biol 26 (23), 9003-9015 (2006)
   PUBMED   17000770
REFERENCE   5  (bases 1 to 2978)
  AUTHORS   Inoko,A., Itoh,M., Tamura,A., Matsuda,M., Furuse,M. and Tsukita,S.
  TITLE     Expression and distribution of ZO-3, a tight junction MAGUK
            protein, in mouse tissues
  JOURNAL   Genes Cells 8 (11), 837-845 (2003)
   PUBMED   14622136
REFERENCE   6  (bases 1 to 2978)
  AUTHORS   Unda,F.J., Perez-Nanclares,G., Le Morvan,V., Hernandez,C.,
            Vilaxa,A., De-la-Fuente,M. and Gorry,P.
  TITLE     Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2,
            ZO-3 and occludin during mouse tooth development
  JOURNAL   Histol Histopathol 18 (1), 27-38 (2003)
   PUBMED   12507281
REFERENCE   7  (bases 1 to 2978)
  AUTHORS   Haskins,J., Gu,L., Wittchen,E.S., Hibbard,J. and Stevenson,B.R.
  TITLE     ZO-3, a novel member of the MAGUK protein family found at the tight
            junction, interacts with ZO-1 and occludin
  JOURNAL   J Cell Biol 141 (1), 199-208 (1998)
   PUBMED   9531559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001108073.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.29569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06680417
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000007.1  9084400-9084573
            175-231             JAXUCZ010000007.1  9086387-9086443
            232-341             JAXUCZ010000007.1  9086523-9086632
            342-444             JAXUCZ010000007.1  9087144-9087246
            445-772             JAXUCZ010000007.1  9088631-9088958
            773-876             JAXUCZ010000007.1  9089224-9089327
            877-1036            JAXUCZ010000007.1  9089508-9089667
            1037-1145           JAXUCZ010000007.1  9089882-9089990
            1146-1207           JAXUCZ010000007.1  9090129-9090190
            1208-1274           JAXUCZ010000007.1  9091058-9091124
            1275-1431           JAXUCZ010000007.1  9091278-9091434
            1432-1540           JAXUCZ010000007.1  9091887-9091995
            1541-1787           JAXUCZ010000007.1  9092302-9092548
            1788-2002           JAXUCZ010000007.1  9092891-9093105
            2003-2098           JAXUCZ010000007.1  9093920-9094015
            2099-2169           JAXUCZ010000007.1  9094980-9095050
            2170-2380           JAXUCZ010000007.1  9095406-9095616
            2381-2481           JAXUCZ010000007.1  9095703-9095803
            2482-2742           JAXUCZ010000007.1  9096135-9096395
            2743-2789           JAXUCZ010000007.1  9096497-9096543
            2790-2978           JAXUCZ010000007.1  9096802-9096990
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2978
                     /gene="Tjp3"
                     /note="tight junction protein 3"
                     /db_xref="GeneID:314640"
                     /db_xref="RGD:1309247"
     exon            1..174
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2892
                     /gene="Tjp3"
                     /note="isoform 3 is encoded by transcript variant 3; tight
                     junction protein ZO-3"
                     /codon_start=1
                     /product="tight junction protein ZO-3 isoform 3"
                     /protein_id="NP_001101543.1"
                     /db_xref="GeneID:314640"
                     /db_xref="RGD:1309247"
                     /translation="MAVADMEELTIWEQHTATLYKDPRRGFGIAVSGGHDRAGGPVVV
                     SDVVPGGPAEGRLQTGDHIVMVNGVSVENVTSAFAIQILKTCTKTANITVKRPRRVQL
                     PATKASPASGHQLSDQEEADHGRGYEGDSSSGSGRSWGERSRRSRAGRRVRMGSHGRR
                     SSCGGSEANGLDLVSGYKRLPKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITE
                     SGLAARNRGLQEGDLILQINGVSSANLSLSDTRRLIEKSEGQLTLLVLRDSGQFLVNI
                     PPAVSDSDSSLMEDISDLTSELSQAPPSHIPPPPLKSRRSPEDSQTDSPVETPQPQRR
                     ERSVDSRAIAEPESPGESRYDIYRVPSRQSLEDRGYSPDTRVVRFPKGVSIGLRLAGG
                     NDVGIFVSGVQAGSPADGQGIQEGDEILQVNDMPFRNLTREEAVQFLLGLPAGEDVEL
                     VIQSKQDIFRKMVQSRVGDSFYIRTHFELEPSPPYGLGFTRGDVFHVVDTLYRGSGSG
                     HGHSSHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLEAAQRAAGLGPGASTGSNP
                     RAEFWRLRGLRRGAKKTMTQRSREDLSALTRQGHYPPYERVVLREASFKRPVVILGPV
                     ADIAMKRLTTEVPEQFEIAESVSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIER
                     LNYVQYYPVVIFCAPESRSALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATI
                     PLNGTSDSWYQEVKAVIQQQQARPIWTAEDQLNGSSEDLDLPGHGLAASSGDLSCDSR
                     ANSDYEDTDGEGTYTDREGEPQDFDEEAPPTALARSSEPVWVDDHQGLMGHGRIAAAE
                     VQADSHYTPDQRRQDSMRTYKHEALRKKFTRARDIESSDEEGYDWGPATDL"
     misc_feature    211..456
                     /gene="Tjp3"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    211..456
                     /gene="Tjp3"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region: PDZ1_ZO1-like;
                     cd06727"
                     /db_xref="CDD:467209"
     misc_feature    order(244..264,301..303,310..312,394..396,406..408,
                     415..420)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    order(244..264,301..303,310..312,394..396,406..408,
                     415..420)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467209"
     misc_feature    736..972
                     /gene="Tjp3"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    736..972
                     /gene="Tjp3"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     Region: PDZ2_ZO1-like_ds; cd06728"
                     /db_xref="CDD:467210"
     misc_feature    order(736..756,769..819,826..834,841..843,847..852,
                     871..873,895..900,904..909,943..963)
                     /gene="Tjp3"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(736..756,769..819,826..834,841..843,847..852,
                     871..873,895..900,904..909,943..963)
                     /gene="Tjp3"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(772..792,808..810,817..819,907..909,919..921,
                     928..933)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    order(772..792,808..810,817..819,907..909,919..921,
                     928..933)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467210"
     misc_feature    1285..1530
                     /gene="Tjp3"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    1285..1530
                     /gene="Tjp3"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; Region:
                     PDZ3_ZO1-like_domain; cd06729"
                     /db_xref="CDD:467211"
     misc_feature    order(1318..1338,1366..1368,1375..1377,1462..1464,
                     1474..1476,1483..1488)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    order(1318..1338,1366..1368,1375..1377,1462..1464,
                     1474..1476,1483..1488)
                     /gene="Tjp3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467211"
     misc_feature    1573..1794
                     /gene="Tjp3"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    1573..1794
                     /gene="Tjp3"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(1597..1599,1603..1605,1612..1614,1624..1626,
                     1687..1692,1774..1776,1780..1785)
                     /gene="Tjp3"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(1597..1599,1603..1605,1612..1614,1624..1626,
                     1687..1692,1774..1776,1780..1785)
                     /gene="Tjp3"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    1921..2451
                     /gene="Tjp3"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     misc_feature    1921..2451
                     /gene="Tjp3"
                     /note="Guanylate kinase homologues; Region: GuKc;
                     smart00072"
                     /db_xref="CDD:214504"
     exon            175..231
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..341
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..444
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..772
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..876
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1036
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1145
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1207
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1274
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1431
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1540
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1787
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..2002
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2098
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2169
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2380
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2481
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2742
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2789
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2978
                     /gene="Tjp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagcaggt gcagcccgga gccgctggca gagccggaga aaggcgggag cgcggcccgg
       61 accccgccgc caccacctcc ggcccaaagt gggggtcggt tgtttccagg cgcctccagg
      121 tccaaggtgg gggctgccct accgtttcca ggacgcctgt tgtacaccat ggcggtggca
      181 gacatggaag agttgaccat ctgggaacag cacacagcca cactgtacaa ggacccccgc
      241 cgaggctttg gcatagctgt gtctggaggt catgaccgag ctggtggacc tgtggtcgtg
      301 tctgatgtgg tacctggagg ccccgctgag ggcaggcttc agactgggga ccacatcgtc
      361 atggtgaatg gtgtctctgt ggagaatgtc acatctgctt ttgccatcca gatccttaag
      421 acctgcacca aaacagccaa cattacagtg aagcgtcccc gaagggtcca actgcctgcc
      481 accaaggcta gcccagcttc tggccaccag ctctcagacc aggaggaagc tgaccatggc
      541 cggggctatg agggggactc ctccagtggc tcaggtcgat cttggggtga gcgttctcgc
      601 cggtccaggg ctggtcgccg cgtcaggatg ggcagccatg ggcgccggag ctcttgtgga
      661 ggttctgagg ccaatggtct ggacctggta tctggctaca agcgcttgcc taagcaggat
      721 gtgctaatga gaccgctaaa gtccgtgctg gtgaaacgaa gaaacagcga agagtttgga
      781 gtgaagctag gcagtcagat cttcataaaa cacatcacag agtccggcct cgctgctcgg
      841 aaccgtgggc tgcaggaggg agaccttatc ttacagatca acggagtgtc cagtgctaat
      901 ctatccctga gtgacacacg gaggctcatt gagaagtcag aggggcagct aaccctgctg
      961 gtgctgaggg acagtgggca gttcctggtg aacatccctc cagcagtgag tgacagcgac
     1021 agctccctaa tggaagacat ctcagacctg acctcggaat tgtcccaggc gcccccttcc
     1081 cacattccac cgccacctct gaagagtcgg cggagccctg aggacagcca gacggattcc
     1141 ccagtggaga ccccacagcc ccagaggcgg gaacggtcgg tggattcaag agccatcgct
     1201 gaaccagagt ctcctggaga aagccgctat gacatttacc gggtccctag tcggcagagc
     1261 ctggaggacc gtggctacag ccccgacacc cgtgtcgtgc gcttccccaa gggtgtgagc
     1321 attggtctgc ggctggccgg cggcaacgac gtgggcatct tcgtgtccgg ggtgcaggca
     1381 ggcagccccg ccgacgggca aggcatccag gaaggggatg agatcttgca ggtgaatgat
     1441 atgccatttc ggaacctgac tcgggaggag gctgtgcagt ttctgttagg gctgcctgca
     1501 ggggaagacg tggagctggt gatacagagc aagcaggaca tcttcaggaa gatggtccag
     1561 tcccgcgtgg gtgactcctt ctacatccgc acacactttg agctggagcc aagcccgccc
     1621 tacggcctgg gcttcactcg cggtgatgtg ttccacgtgg tggacacgtt gtaccggggc
     1681 tctgggtcag gccacgggca cagcagccat gggggtctct ggctggcggc ccgaatgggc
     1741 agagatctcc gagagcaaga acgaggcgtc attcccaacc agagcagggc cgagcagctg
     1801 gccagtttgg aggccgcgca gcgggccgcg ggcctggggc caggcgcctc aacaggctcc
     1861 aacccacggg ccgagttctg gcgactccga ggtctccggc gaggggccaa gaagacaatg
     1921 acccagcgga gccgcgagga cctgtcggcg ctgaccaggc agggacacta cccaccctac
     1981 gagcgagtcg tgctacgaga agccagtttt aagcgccccg tggtgatcct aggacccgtg
     2041 gcagacattg ctatgaagag actgacaaca gaggtgccag agcagtttga gattgcagaa
     2101 agcgtgtccc ggactgacag cccatccaag atcatcaaat tggacacagt gcgggtgatc
     2161 gcagagaggg acaagcacgc actcctggat gtcaccccct ctgccatcga gcgcctcaac
     2221 tacgtgcagt actaccctgt cgtcatcttc tgtgctccgg agagccggtc agcgctcaag
     2281 gcccttcgcg agtggctggc ccccgcctct cgccgcagca gccgccgcct gtatgcgcag
     2341 gcccagaagc tgcagaaaca cagtggccac ctcttcaccg ccaccattcc cctgaatggc
     2401 actagtgact cctggtacca ggaagtcaag gctgtcatac agcaacagca ggcgcgaccg
     2461 atctggactg cggaggacca gctgaatggc tcatccgagg accttgacct gccgggccat
     2521 gggctggccg ccagctctgg agacctcagc tgtgacagtc gggctaacag cgactacgaa
     2581 gacaccgatg gggagggcac ctatacggat agagagggcg aaccccagga tttcgatgag
     2641 gaagccccac ccacggccct ggcccggtcc tcagagcctg tgtgggtaga tgaccaccag
     2701 gggctgatgg gtcatgggag gatcgcagcc gcggaggtgc aggccgacag ccactacacc
     2761 ccggaccagc ggcgccaaga cagcatgcgg acctacaagc atgaggccct gagaaagaag
     2821 ttcacaagag cccgggacat cgaatcctct gacgaagaag gctatgactg gggcccagcc
     2881 accgacctgt gacctgtgca gtccaccagc ctgccacaag ccctcaagct tctgaccatt
     2941 taataaacct ttaaaagtat tttttacatt agaaaata
//
LOCUS       NM_001437954            2502 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus AT-rich interaction domain 3A (Arid3a),
            transcript variant 3, mRNA.
ACCESSION   NM_001437954
VERSION     NM_001437954.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2502)
  AUTHORS   Tidwell,J.A., Schmidt,C., Heaton,P., Wilson,V. and Tucker,P.W.
  TITLE     Characterization of a new ARID family transcription factor
            (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated
            immunoglobulin gene transcription
  JOURNAL   Mol Immunol 49 (1-2), 260-272 (2011)
   PUBMED   21955986
REFERENCE   2  (bases 1 to 2502)
  AUTHORS   Nixon,J.C., Rajaiya,J. and Webb,C.F.
  TITLE     Mutations in the DNA-binding domain of the transcription factor
            Bright act as dominant negative proteins and interfere with
            immunoglobulin transactivation
  JOURNAL   J Biol Chem 279 (50), 52465-52472 (2004)
   PUBMED   15456761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.29828.1,
                                           SRR26643284.9728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000007.1  10431027-10431230   c
            205-837             JAXUCZ010000007.1  10427109-10427741   c
            838-1153            JAXUCZ010000007.1  10426019-10426334   c
            1154-1226           JAXUCZ010000007.1  10411872-10411944   c
            1227-1410           JAXUCZ010000007.1  10409498-10409681   c
            1411-1658           JAXUCZ010000007.1  10408421-10408668   c
            1659-1955           JAXUCZ010000007.1  10407232-10407528   c
            1956-2054           JAXUCZ010000007.1  10406751-10406849   c
            2055-2502           JAXUCZ010000007.1  10405925-10406372   c
FEATURES             Location/Qualifiers
     source          1..2502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2502
                     /gene="Arid3a"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
     exon            1..204
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            205..837
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    224..226
                     /gene="Arid3a"
                     /note="upstream in-frame stop codon"
     CDS             467..2251
                     /gene="Arid3a"
                     /note="dead ringer homolog 1; AT rich interactive domain
                     3A (Bright like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     3A"
                     /protein_id="NP_001424883.1"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
                     /translation="MKLQAVMETLIQRQQRARQELEARQPPLPPPPEPAGVQARTTMT
                     DEDREPENARMHRTQMAALAAMRAAAAGLRHPSSPGGSEDEDTAQGGTLSSPALHGSG
                     QEGPGHTEGDGHLMDMGSDDDTKPKWEEQELEELGEEEEEEDEDDFEEEEEDEEEEGL
                     GLPESASLGSAGLFTRKAPPTQTFRGDGGPRMLSGPERLGPGPAHPSHVASQMPPPDH
                     GDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVL
                     VTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPN
                     ELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLSSPKLPVTSLGLAASTNGSSITPT
                     PKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREK
                     LESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDPAVNL
                     TSANGSNSISMSVEMNGIVYTGVLFAQPPPPTPPPASSKGGVSSIGTNNTMGNRTGAS
                     GSAGSSGQVGLAGVSAPTMSSTSNNSLP"
     misc_feature    1115..1513
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    1115..1513
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    order(1241..1261,1334..1336,1340..1345,1352..1354,
                     1376..1387,1391..1399,1403..1405,1493..1498)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     misc_feature    order(1241..1261,1334..1336,1340..1345,1352..1354,
                     1376..1387,1391..1399,1403..1405,1493..1498)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     exon            838..1153
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1226
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1410
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1658
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1955
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2054
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2502
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaggggccg cgacctgaag ttttccgtcc actctgtggc ggctctccag ctcccctcca
       61 cctcctccca ccgtggacgc cctcagattg agttggagag gggggacccc ggtgtggtgt
      121 cctgggaaag cttggaaagg gggaccttgc agagacaccc accacctcct cctgcgtccc
      181 cggggctgct gaatcaccgg cgaggagtct gcaggtgctt gaatgagccc gacaccagcc
      241 tctgcccctg ggtgcccgac gtaacaacaa ggatcccact ggtcgcccct ggcatgcccc
      301 accagccttc accctgagtt ggcagccccc acccctgcca gccgtcaccc tgcattgttc
      361 cggctccccc gaagtcccca cgctgcagtg cggccaagac ccctccccac gggggccacc
      421 cccaccaagt gcccctggtg cccggggtgg cccggcccgt cgggccatga agctgcaggc
      481 agtgatggag actcttattc agaggcaaca gcgagcccgg caggaactgg aggctcgaca
      541 gcctccacta cccccaccac cggagcccgc tggtgtccag gctcggacca ccatgacaga
      601 tgaggacagg gagcctgaga atgcccgtat gcataggacg cagatggctg cactggctgc
      661 catgcgggct gctgccgccg gcttgagaca tccgtcctct cccgggggct cggaggacga
      721 agacacagcc cagggaggga ctctgagttc acctgccctg catggaagtg gccaggaggg
      781 accgggacac actgagggag acggccattt gatggacatg ggctccgatg atgacacgaa
      841 gcccaagtgg gaagaacaag agctggaaga actgggggaa gaggaagagg aggaggatga
      901 agatgacttt gaggaagaag aggaggatga ggaggaagaa ggcctgggcc tcccagagtc
      961 tgccagcctg ggctccgcag gcctgtttac ccgcaaggcc ccacctactc agaccttccg
     1021 tggagacggt ggtcccagaa tgctcagtgg ccctgagcgc ctgggacctg gcccggccca
     1081 ccccagtcat gtggcgtccc agatgccacc accggaccat ggggactgga catttgagga
     1141 gcagttcaaa cagctctatg aactggacgc agaccccaag aggaaagagt tcctggacga
     1201 cctgttcagc ttcatgcaga agcggggcac tccggtgaac cggatcccca tcatggccaa
     1261 gcaggtcctc gacctgttca tgctgtatgt gctggtgacg gaaaagggcg gtctggtaga
     1321 ggttatcaac aagaagctgt ggagggagat caccaagggg ctcaacctgc ccacctccat
     1381 caccagtgct gccttcacac ttcggacaca gtacatgaag tatctttacc cctatgagtg
     1441 tgagaggcga ggcctgagca gccccaatga gctccaggct gccatagaca gcaaccgccg
     1501 ggagggcagg cgccagagct tcgggggctc cctctttgct tactcaccca gtggagccca
     1561 cagcatgctg tcctcaccca agctaccggt gacttctttg ggccttgctg ccagcaccaa
     1621 tggcagctct atcaccccaa cacccaagat caagaaagag gaagactcag ccatccccat
     1681 cacagtccca ggccgcctac ccgtgtctct ggcaggccac cctgtcgtag cagcccaggc
     1741 agcggctgtg caagccgcag cagcccaggc tgcagttgcg gcccaggcag ccgccctgga
     1801 acaactccgg gagaagctgg aatccacgga gcctccggaa aagaagatgg ccctggttgc
     1861 agatgagcag cagcgtctca tgcagcgagc cgtgcagcag agcttcctgg ccatgacagc
     1921 ccagctgccc atgaacatcc ggatcaacag ccaagcctct gagagtcgcc aggacccagc
     1981 tgtaaatctc accagtgcca atggcagcaa cagtattagc atgtccgtgg agatgaacgg
     2041 tattgtatac acaggggtgc tgttcgctca gccaccacct cctacgccac ctcccgcctc
     2101 cagcaaaggt ggtgtgagca gcattggtac caacaacacc atgggtaacc ggacaggagc
     2161 cagtggcagt gctggcagca gcggccaagt ggggctggct ggggtgtctg cacccaccat
     2221 gtcttctacc tcaaataact ccttgcctta aaaggaaacc aagttgcatg gctgcccacc
     2281 cgccacagga accacatggc cacacagggg gacctgggac gtcagaagaa tcccagtggg
     2341 ctgggcagat tcccaaggag ccacactgac gccaaaaagg agagagagag atagagagag
     2401 aaagagagag agagaaaata tatatatata catatatata tatacatata gaaagagata
     2461 ggtagatgga gaaacagatc taataaatca gggcaaagca aa
//
LOCUS       NM_001437902            4437 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 5, mRNA.
ACCESSION   NM_001437902 XM_039078857
VERSION     NM_001437902.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4437)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078857.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.26756.1,
                                           SRR26643299.32861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-312             JAXUCZ010000007.1  122187562-122187662
            313-440             JAXUCZ010000007.1  122193494-122193621
            441-596             JAXUCZ010000007.1  122194723-122194878
            597-679             JAXUCZ010000007.1  122198007-122198089
            680-727             JAXUCZ010000007.1  122198472-122198519
            728-970             JAXUCZ010000007.1  122203808-122204050
            971-1157            JAXUCZ010000007.1  122207498-122207684
            1158-1295           JAXUCZ010000007.1  122210547-122210684
            1296-1361           JAXUCZ010000007.1  122213276-122213341
            1362-1474           JAXUCZ010000007.1  122216165-122216277
            1475-1588           JAXUCZ010000007.1  122216625-122216738
            1589-1715           JAXUCZ010000007.1  122218925-122219051
            1716-1868           JAXUCZ010000007.1  122220112-122220264
            1869-2084           JAXUCZ010000007.1  122223641-122223856
            2085-2149           JAXUCZ010000007.1  122225088-122225152
            2150-2265           JAXUCZ010000007.1  122226909-122227024
            2266-2351           JAXUCZ010000007.1  122228286-122228371
            2352-2432           JAXUCZ010000007.1  122228849-122228929
            2433-2530           JAXUCZ010000007.1  122229298-122229395
            2531-2588           JAXUCZ010000007.1  122229728-122229785
            2589-2710           JAXUCZ010000007.1  122230077-122230198
            2711-2874           JAXUCZ010000007.1  122230444-122230607
            2875-3031           JAXUCZ010000007.1  122231523-122231679
            3032-3120           JAXUCZ010000007.1  122231770-122231858
            3121-3316           JAXUCZ010000007.1  122232571-122232766
            3317-3544           JAXUCZ010000007.1  122235416-122235643
            3545-4437           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4437
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..312
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..440
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..596
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..679
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    657..659
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            680..727
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..970
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..3593
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 1 is encoded by transcript variant 5;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 1"
                     /protein_id="NP_001424831.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLVSTHHLHSSSEDEDIEGTFPNELSLQQAFS
                     EYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIEADEDSPSAALFEAC
                     CSDRIQPFDDDEEDIWEDEETRCTARVMARARFGAPHTSENYSKKAVGHGGQGRKTGS
                     PTARNVPGLATPSSPTQKEGPRSESDSAGTTWTAVFDEPVNPLSAASGAARDVGSSAW
                     AAGPSVAEEKGWAKFTDFQPFCCSETGPRCSSPVDMDHSNAEGGQSPGPEKAFGPTSP
                     CAWNVCVTRKAPLVASDSSSSGGSDSEDDEKAAGAVEALCAGHTGKASPPPRTAEAAA
                     GRAECPDSTVLAPACPAPSEVTISPAVATIAPSKAGSPTATIVVSSSVATAVPPGPIM
                     AVTTTAPAIVATLGTMTKDRKTDALPDGAALNGPV"
     misc_feature    1125..2345
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    1125..2345
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2676..>3563
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2676..>3563
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            971..1157
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1295
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1361
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1474
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1588
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1715
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1868
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2084
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2149
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2265
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2351
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2432
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2530
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2588
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2710
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2874
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3031
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3120
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3316
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3544
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..4437
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggttctcagc cttggctgtc ctggaactct
      241 ctccatagac caggcgggcc ttgaactcat agagatctgc ctacctctgc ctcctgagtg
      301 ctgagatcaa aggtaaacca accaaaactc tttgcagaat gaaaacacct tttttaaaat
      361 tgcatgtata caaaagaaag agcccaaatg ctttttattt tgcctgaata caagatttaa
      421 acaaggtatt gccatagaag tctctaccac agcgcgttct gttggactct ttcacggaac
      481 tataggatca catgggcagc acttgtgttt gattctaccc tctttcttcc ggtcggttct
      541 gtcaccctgg gaaatagaga agcagaacgt acggctcctt tcttcattca ctgctggatc
      601 aatgtccagg gccaaggcag ttttgtttgt gtggatttct gtttactgct gcatggtaga
      661 ggctgccgaa ccccataagg aaacattgtt gcggtttgca catccagtct gagagacttc
      721 tgcattgctc tgtgaccacc atcatgttct ggaaatttga cttgaatacc acgtcccacg
      781 ttgacaagct cctcgacaag gaacatgtga cactgcagga attaatggat gaagatgaca
      841 tcttgcaaga gtgtaaggct cagaaccaga agctgctgga cttcctgtgc aggcagcagt
      901 gtatggagga gctggtgaac ctcatcacac aagacccacc ccaggacatg gaagagaagg
      961 tccgattcaa atatccaaac acagcctgtg agcttctgac ttgtgatgtg ccgcagatca
     1021 gcgacagact aggcgaggac gagagtctgc tgaaccttct gtatgacttc ttggaccagg
     1081 agccaccact caaccctctg cttgccagtt tttttagcaa gaccattggc aatctcattg
     1141 caaggaaaac cgaacaggtg atcatgttct tgaagaagaa ggacaagttc atcagtctga
     1201 tactgaagca cataggcacc tcagctctca tggacctgct gctacgcctg gtcagctgcg
     1261 tggaaccagt tgttctccgg caggaggtcc tacattggct taatgaagag aaagtcatcc
     1321 agagacttgt ggaattgatc catccccacc aggatgaaga taggcagtca aatgcttctc
     1381 aggcactctg tgacatcatc aggctgggca gagaccaggg cagtcagctg caggagactg
     1441 tggagccgga tcccctcctc acagcactgg agtcgcagga ctgtgtggaa cagcttctga
     1501 agaacatgtt tgatggggat cggacggaga gctgcctggt cagtgggatg caggtgctgc
     1561 ttgccctgct ggagccaagg cgtgttggaa cagaaggctt ggtggactcc ttttctcagg
     1621 gactggaaag gtcatactct gtcagcagca gcatcctgca cggcattgag ccatggctga
     1681 agaatttcca tcagctcctg ctcaacccac caaagaagaa agcaatcctg accactattg
     1741 gcgtgctaga ggagcccctg gggaatgctc gtcttcatgg tgcacgcctc atggctgcac
     1801 tgctgcacac aaatacgccc agcatcaacc aggagctctg ccggctcaac accatggact
     1861 tactgctgga cctgtttttt aagtacacct ggaataactt cttacacttg caagtggagc
     1921 tgtgcatagc cgctattctc tcccacgctg gtcgggagga gcaggcagaa gctggcagat
     1981 cagatggcaa agtggaacct gtgcagggga gtggagatgg gggtgggaag ccggagacca
     2041 ccccgtccat caccagccct cctgagaaca caatggtgac ccatctgttc cagaagtgct
     2101 gcctggttca gaggatcctg gaagcctggg aagccaatga caacacacag gcggcaggtg
     2161 gcatgagacg tgggaatatg ggccacctca caaggatcgc caacgcagtt gtacagaacc
     2221 tggagcaggg cccggtgcag acacacatca gtgaagtcat ccgagggctc cctgcagagt
     2281 gccgtggacg ctgggagagc tttgtggaag agacactgat ggagaccaac cgcaggaaca
     2341 ctgtggacct ggtgagcact caccaccttc actcctcaag tgaggacgag gacattgagg
     2401 gtactttccc taacgagctg tcccttcagc aggccttctc tgagtaccag atccagcaga
     2461 tgacagcaaa ctttgtggat cagtttggct tcaatgatga ggagtttgca gaccaggatg
     2521 acaacatcaa tgccccattt gaccggattg cagagatcaa cttcaacatt gaagccgatg
     2581 aggacagtcc cagtgcagct ctgtttgaag cttgctgcag tgatcggatc cagcccttcg
     2641 atgatgacga ggaggacatt tgggaggatg aggagactcg atgcacggcc cgggtgatgg
     2701 ccagagccag gtttggagcc cctcacacct cagaaaacta ctcaaagaag gccgtgggac
     2761 atggaggcca gggcaggaag actggctccc ccacagctag gaatgtgcct ggactggcca
     2821 cgccttcatc ccctacacag aaagaaggtc ctcgctcaga aagtgattca gcaggtacta
     2881 catggacagc agtttttgat gagccagtga acccgctgtc tgcagcctca ggagctgcga
     2941 gggatgtggg ttctagtgca tgggcggctg gtccttcagt tgcagaggag aaaggctggg
     3001 ccaaattcac cgacttccag cctttctgct gctctgagac agggccccgg tgcagctctc
     3061 ctgtggacat ggaccacagc aatgccgagg gtggccagag tccaggccca gagaaagcct
     3121 ttggtcctac ctcgccttgt gcctggaacg tgtgtgtcac taggaaggcc ccactggtag
     3181 cctctgacag cagctcctct gggggatctg acagtgaaga tgacgagaag gcagcgggtg
     3241 ctgtggaagc tctgtgcgca ggccatactg gaaaggcctc cccgccaccc aggacagcag
     3301 aggctgctgc tggcagggcc gagtgtcctg acagcaccgt gttagcccct gcctgccctg
     3361 ctccttcaga agtgaccatc agtcctgccg tggctaccat agcaccaagc aaggcaggct
     3421 ctcccacagc caccatagtg gtctcttcct cagtggctac tgcggtaccc ccaggaccaa
     3481 tcatggcagt aaccacaaca gctccagcca tagttgcaac cctggggaca atgacaaagg
     3541 acaggaagac agatgccctg ccagatggag ctgccttaaa tggccctgtg taatggctgc
     3601 cgcccagcta tggcccaccc tggtcaggct gcctccttaa tcaagaagac tacctggtga
     3661 tgcaattttt tttaatttaa ctttaaaata aatgctgcat ttggtaaagc tggcagtgga
     3721 acccgttgga tgacccagct catgtttctc ctgcctgccc ttggtcctgt tggaggacag
     3781 gatgcacctg gccattccca ggcccaggtc ttggtgtggc aatgcagccc tgacgcgcag
     3841 cttcaacctg caggagttgg ggagggaaca agaccctaag gggccagcac catcggatgg
     3901 gcaggaaggg tgcggatctc caggcgctgg tttcatctgt atttttaacg catggaggaa
     3961 aagccgtttt ttgcactttg tacccagcta cagtacaggg tctctctagg ctcagggcag
     4021 atgtacaggc ctgagttgga gagacctgat ccccactaat aatactacat gggggtctgg
     4081 cactagtttg gccacatgag gtcaaacccc agttctagct gcccagggac tcctgggagc
     4141 tggtgttgaa tcaggctaca cattttgact gccttaaaaa caaagaccct ctggacccgg
     4201 tgcagtggtc tctgtgctca gcagggcaga ctggcacact cgggtggggg ttggagctgc
     4261 accagacatg taagagtgga cacggaagag cactgggagg cctagggacc gggcgggccc
     4321 atagtgtcca ggaagagtct aaagtctatg ttgtcttttt tttttttttt ttttaaatgt
     4381 tctgaccttc tgacagggca tctaaccccc aataaaaagg atcattctta ctgaaaa
//
LOCUS       NM_001437977            2240 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            5, mRNA.
ACCESSION   NM_001437977
VERSION     NM_001437977.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3039931.1,
                                           SRR26360181.119266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 JAXUCZ010000007.1  97509310-97509314
            6-35                JAXUCZ010000007.1  97509567-97509596
            36-180              JAXUCZ010000007.1  97509983-97510127
            181-478             JAXUCZ010000007.1  97510569-97510866
            479-665             JAXUCZ010000007.1  97512128-97512314
            666-840             JAXUCZ010000007.1  97512838-97513012
            841-946             JAXUCZ010000007.1  97515701-97515806
            947-994             JAXUCZ010000007.1  97516474-97516521
            995-1170            JAXUCZ010000007.1  97517084-97517259
            1171-1312           JAXUCZ010000007.1  97517640-97517781
            1313-1386           JAXUCZ010000007.1  97518224-97518297
            1387-2244           JAXUCZ010000007.1  97518931-97519788
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2240
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..31
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            32..176
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    90..92
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            177..474
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1673
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 1 is encoded by transcript variant 5;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 1"
                     /protein_id="NP_001424906.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELVASILEHNCNQTEETT
                     SPLPTGVLCALKSEDEVLILNLVQGCGLELEKSGCQLPWDPTVVPQLSALYACLTGLQ
                     LLTDPSPGLSRTVPEEETLICP"
     misc_feature    264..968
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    264..968
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    1026..1538
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    1026..1538
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            475..661
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            662..836
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            837..942
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            943..990
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1166
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1308
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1382
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2240
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcccagga gggcgatgct tgaggaccca gacaggtgaa tcccagagcc cacctcaggg
       61 aggtcctggc ttcaatgtca agaaaaccat gatacaacgc aactggagat aagaggaaac
      121 tggagtccac cttaggtcct tccgcacagg aatttgtaca accacaggga aagcaaatca
      181 ggccagcttg cagctatcac gaagggatcc catatccagc ccgggatgat attgtccctt
      241 gcctctcaag gagcatgtca tctctgttct tgaggagcac caaaagcctg gtgagagagc
      301 tgggcaggaa gggtgagctg gtgccggtag acagcctgaa cagttcacag cgcctgcgcc
      361 ccttctgcct ggtgaggaag aagcacaagc attccctctg gccttgggac acacccctca
      421 tccccacaga cttctccctg ctggatgtgc tggagcctgg ctgccctgac ccagaggtga
      481 accacagcaa gcccatctat tcctgggaga aggaggcaga gggattgaca ggagctgtga
      541 gcgtgagtgc tgggctgcag agccaggtga ctggaagcgg cacgaccacc tgcctctctg
      601 ccttggcggt gcagacactc tgggtctccc cgtttacctg ggagatgctt cttgagaaaa
      661 ggaaactgag gtcgcctagg ccctcgttcc tccaggaact acagagccgg aaggagaggg
      721 agagcctata tgtggtgacc gaggctgtgg agaccctgca agataccata cttcagagcc
      781 acgaccaaat gcgaggagcc ggacagctgt ccctcctaca gctgggccat gttcaggtcc
      841 agggacagag ccatgtggac acagagaaga tggtgagcat cccacagggc agtgttctgg
      901 cctacagggt tctgcagcta gtggtggaag aagatggctg ggctgtcctt tacttccctg
      961 aaagaaagct ctgcaggaat gccagagtag ctatagcctt cagccaggaa tcaggagaag
     1021 agtctaactt ctacagcttg cgggaccaag cagatagcca gttgcaggac ctggtcacat
     1081 tatcctcaga gcgacgggcc acattgcttg gtgccctcca ggagctacta cgggatcagc
     1141 aggcactcca ggagctagag gatacgctgg aacaggctct ggacacaggg ctgctggcac
     1201 agctggaggg ccctggaggc tgtgtcttat gcatcctcca agactctaca agcaacttgt
     1261 catgctcgaa aggcagggct atcctctata ttcttggagc cttagcagca ctgagtgaac
     1321 cccagcattg cctgctggcc cagtccatag agagacaaat cctatctgag gaactggagc
     1381 tggtggcaag catcttggag cacaactgta atcagacgga ggaaacaacc tctcccctcc
     1441 caacaggagt actctgtgcc ctgaagagtg aggatgaggt cctcatccta aacctggtgc
     1501 agggctgtgg gctagagcta gagaagtctg gctgccagct cccctgggac cctacagtgg
     1561 tacctcagct ttctgcactc tatgcatgcc tcacagggct gcagctactg actgacccaa
     1621 gccctgggct ttctaggaca gtgcctgaag aggaaacact tatctgtccc taaggtctca
     1681 tccaacctga ctcctggcag cctgggatgt cactaaccct ctctagtggt cacagctgat
     1741 gacagggttt caccaggaaa ggccccacac tacacttaag actggttcca gacatcggaa
     1801 acacctattc agaacaagta tcctgaatca ggattctgtc tgagcagtgc aggctggctg
     1861 cagaacagtt tggctgtgta tcttaggtag catagtcccc tctgtactca ggtaaaatca
     1921 gccattgtaa aatgagattt gtggtcattc cccaggcaca agaactttgt aaaagtatat
     1981 gtgacatgct tacaagagtg ctgttattgt atggtggcaa ggtgagacca cagggagaag
     2041 tagctcttca gggtaacaca ggacaagctg tcctgccttg cgtttcctgc attggcctcc
     2101 ttcgttccat ctgtcacatg acaaaacaga acaagctgct caggttccag cccattgtac
     2161 caatgactat acaatgtcag agcatgggat cgagtcagtt gaataaataa gaccaggctc
     2221 ttcccagtct tccttgttaa
//
LOCUS       NM_001437919            4226 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus adenosylhomocysteinase-like 1 (Ahcyl1),
            transcript variant 3, mRNA.
ACCESSION   NM_001437919 XM_006233166
VERSION     NM_001437919.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4226)
  AUTHORS   Harvey,K.E., LaVigne,E.K., Dar,M.S., Salyer,A.E., Pratt,E.P.S.,
            Sample,P.A., Aryal,U.K., Gowher,H. and Hockerman,G.H.
  TITLE     RyR2/IRBIT regulates insulin gene transcript, insulin content, and
            secretion in the insulinoma cell line INS-1
  JOURNAL   Sci Rep 12 (1), 7713 (2022)
   PUBMED   35562179
  REMARK    GeneRIF: RyR2/IRBIT regulates insulin gene transcript, insulin
            content, and secretion in the insulinoma cell line INS-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4226)
  AUTHORS   Borth,H., Weber,N., Meyer,D., Wartenberg,A., Arlt,E., Zierler,S.,
            Breit,A., Wennemuth,G., Gudermann,T. and Boekhoff,I.
  TITLE     The IP3 R Binding Protein Released With Inositol
            1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and
            Spermatozoa
  JOURNAL   J Cell Physiol 231 (5), 1114-1129 (2016)
   PUBMED   26439876
  REMARK    GeneRIF: The present study documents that IRBIT is expressed in
            Leydig and Sertoli cells.
REFERENCE   3  (bases 1 to 4226)
  AUTHORS   Ando,H., Hirose,M., Gainche,L., Kawaai,K., Bonneau,B., Ijuin,T.,
            Itoh,T., Takenawa,T. and Mikoshiba,K.
  TITLE     IRBIT Interacts with the Catalytic Core of Phosphatidylinositol
            Phosphate Kinase Type Ialpha and IIalpha through Conserved
            Catalytic Aspartate Residues
  JOURNAL   PLoS One 10 (10), e0141569 (2015)
   PUBMED   26509711
  REMARK    GeneRIF: IRBIT forms signaling complexes with PIPKIalpha and
            NBCe1-B, whose activity is regulated by PI(4,5)P2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4226)
  AUTHORS   Park,S., Shcheynikov,N., Hong,J.H., Zheng,C., Suh,S.H., Kawaai,K.,
            Ando,H., Mizutani,A., Abe,T., Kiyonari,H., Seki,G., Yule,D.,
            Mikoshiba,K. and Muallem,S.
  TITLE     Irbit mediates synergy between ca(2+) and cAMP signaling pathways
            during epithelial transport in mice
  JOURNAL   Gastroenterology 145 (1), 232-241 (2013)
   PUBMED   23542070
REFERENCE   5  (bases 1 to 4226)
  AUTHORS   He,P., Klein,J. and Yun,C.C.
  TITLE     Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated
            by inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein
            kinase II
  JOURNAL   J Biol Chem 285 (36), 27869-27878 (2010)
   PUBMED   20584908
  REMARK    GeneRIF: IRBIT is critically involved in mediating activation of
            NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases
            II-dependent pathway.
REFERENCE   6  (bases 1 to 4226)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   7  (bases 1 to 4226)
  AUTHORS   Yang,D., Shcheynikov,N., Zeng,W., Ohana,E., So,I., Ando,H.,
            Mizutani,A., Mikoshiba,K. and Muallem,S.
  TITLE     IRBIT coordinates epithelial fluid and HCO3- secretion by
            stimulating the transporters pNBC1 and CFTR in the murine
            pancreatic duct
  JOURNAL   J Clin Invest 119 (1), 193-202 (2009)
   PUBMED   19033647
REFERENCE   8  (bases 1 to 4226)
  AUTHORS   He,P., Zhang,H. and Yun,C.C.
  TITLE     IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3
            activity in response to calcium
  JOURNAL   J Biol Chem 283 (48), 33544-33553 (2008)
   PUBMED   18829453
REFERENCE   9  (bases 1 to 4226)
  AUTHORS   Shirakabe,K., Priori,G., Yamada,H., Ando,H., Horita,S., Fujita,T.,
            Fujimoto,I., Mizutani,A., Seki,G. and Mikoshiba,K.
  TITLE     IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein,
            specifically binds to and activates pancreas-type Na+/HCO3-
            cotransporter 1 (pNBC1)
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9542-9547 (2006)
   PUBMED   16769890
REFERENCE   10 (bases 1 to 4226)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006233166.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2272302.1,
                                           SRR26643298.12967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-775               JAXUCZ010000002.1  198015998-198016772 c
            776-887             JAXUCZ010000002.1  197996976-197997087 c
            888-1031            JAXUCZ010000002.1  197994562-197994705 c
            1032-1132           JAXUCZ010000002.1  197993582-197993682 c
            1133-1235           JAXUCZ010000002.1  197993022-197993124 c
            1236-1330           JAXUCZ010000002.1  197991814-197991908 c
            1331-1437           JAXUCZ010000002.1  197990910-197991016 c
            1438-1554           JAXUCZ010000002.1  197989966-197990082 c
            1555-1618           JAXUCZ010000002.1  197989657-197989720 c
            1619-1707           JAXUCZ010000002.1  197988861-197988949 c
            1708-1778           JAXUCZ010000002.1  197988425-197988495 c
            1779-1873           JAXUCZ010000002.1  197987990-197988084 c
            1874-1972           JAXUCZ010000002.1  197987807-197987905 c
            1973-2041           JAXUCZ010000002.1  197987176-197987244 c
            2042-2120           JAXUCZ010000002.1  197986588-197986666 c
            2121-2241           JAXUCZ010000002.1  197984726-197984846 c
            2242-4226           JAXUCZ010000002.1  197982335-197984319 c
FEATURES             Location/Qualifiers
     source          1..4226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4226
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="adenosylhomocysteinase-like 1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
     exon            1..775
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    719..721
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="upstream in-frame stop codon"
     exon            776..887
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             797..2248
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /EC_number="3.13.2.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     S-adenosylhomocysteine hydrolase-like 1; putative
                     adenosylhomocysteinase 2; adoHcyase 2;
                     S-adenosyl-L-homocysteine hydrolase 2;
                     S-adenosylhomocysteine hydrolase-like protein 1;
                     IP3R-binding protein released with inositol
                     1,4,5-trisphosphate"
                     /codon_start=1
                     /product="S-adenosylhomocysteine hydrolase-like protein 1
                     isoform 3"
                     /protein_id="NP_001424848.1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
                     /translation="MQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSP
                     REKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIV
                     GCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDD
                     FWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQL
                     SKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVG
                     KGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVT
                     REHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAE
                     GRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHL
                     PSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY"
     misc_feature    797..964
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    848..931
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: PEST. /evidence=ECO:0000250|UniProtKB:O43865,
                     ECO:0000250|UniProtKB:Q80SW1"
     misc_feature    857..859
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine, by PKD.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    866..868
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    875..877
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    884..886
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    905..907
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80SW1; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    971..2242
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    971..2242
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    order(998..1000,1007..1009,1019..1021,1028..1033,
                     1433..1435,1442..1447,1493..1495,1499..1501,1511..1516,
                     1526..1528,1535..1540,1550..1552,1559..1564,1571..1591,
                     1613..1618,1625..1627,1652..1657,1661..1663,1676..1702,
                     1706..1717,1721..1732,1739..1741,1778..1792,1820..1828,
                     1859..1861,1910..1915,1928..1930,2000..2002,2006..2008,
                     2012..2017,2024..2026,2102..2104,2120..2125,2132..2137,
                     2144..2146,2153..2158,2162..2170,2174..2176,2183..2188,
                     2195..2200)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    order(998..1000,1007..1009,1019..1021,1028..1033,
                     1433..1435,1442..1447,1493..1495,1499..1501,1511..1516,
                     1526..1528,1535..1540,1550..1552,1559..1564,1571..1591,
                     1613..1618,1625..1627,1652..1657,1661..1663,1676..1702,
                     1706..1717,1721..1732,1739..1741,1778..1792,1820..1828,
                     1859..1861,1910..1915,1928..1930,2000..2002,2006..2008,
                     2012..2017,2024..2026,2102..2104,2120..2125,2132..2137,
                     2144..2146,2153..2158,2162..2170,2174..2176,2183..2188,
                     2195..2200)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    1067..1258
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: Interaction with BCL2L10.
                     /evidence=ECO:0000250|UniProtKB:O43865"
     misc_feature    order(1112..1114,1118..1120,1124..1129,1340..1342,
                     1415..1420,1505..1507,1517..1519,1988..1990,2003..2005,
                     2018..2020,2030..2032)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(1112..1114,1118..1120,1124..1129,1340..1342,
                     1415..1420,1505..1507,1517..1519,1988..1990,2003..2005,
                     2018..2020,2030..2032)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(1418..1426,1520..1522,1532..1534,1607..1609,
                     1613..1621,1673..1684,1691..1693,1772..1783,1790..1792,
                     1844..1852,1979..1981,1985..1987,2003..2005)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(1418..1426,1520..1522,1532..1534,1607..1609,
                     1613..1621,1673..1684,1691..1693,1772..1783,1790..1792,
                     1844..1852,1979..1981,1985..1987,2003..2005)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    1496..1999
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: NAD binding. /evidence=ECO:0000250"
     misc_feature    1826..1828
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    2213..2245
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: PDZ-binding. /evidence=ECO:0000250"
     exon            888..1031
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1132
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1235
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1330
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1437
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1554
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1618
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1707
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1778
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1873
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1972
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2041
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2120
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2241
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..4226
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttgcgtg cgtgcttgcg tgtggcggag gtggctgcgc gggcaggtcg gagctgcgtg
       61 ctgttgcttc tggttcttct gtggccgccg tcgctgtccg gcaggcttgg gttgagaagc
      121 cgacaaggcg cgcgggtcac agcccttcgg aagcccaagg agctcggcgc ggggcctggc
      181 gggaaggcgg gcgagcgcgt ggcccagggc gccgcgcgga cgggcgggcg cccgtgaggg
      241 gaagaggcgg gggcggcggg ttagccgcgg gccgggccgg ccgggggatg tcgatgcctg
      301 acgcgatgcc gctgcccggt gtcggggagg agctgaaaca ggccaaggag atcgaggacg
      361 ccgagaagta ctccttcatg gccacggtca ccaaggctcc caagaaggtg cgggggctct
      421 gggtggcggc gagggccctc gcggaagggg cgcgagcaag ccccgggccc ggactcgggt
      481 agttcgggac ttcgggctaa ggtttggggt gctcaggacc attgacacga taaagggggt
      541 ggccggtgag cggcgatggg cctatctaga gccaaagagg ccgctctgac ctcgcttttc
      601 tttgtccctc ggccggagtc ctcctggatc tttctgaagc ccgacagggc caggccttaa
      661 attcgcgaca gacttttcct ggatggagga gggccttgaa gacgagattg ggagggggtg
      721 aacgactcat ctgacctgtc caggggatga gggtgtgcag gaaatttccc ctcagcaaat
      781 ccagtttgcg gatgacatgc aagagttcac caaattccct actaagactg gccggagatc
      841 cttgtctcgc tccatctcac agtcctccac agacagctac agttcagctg catcctatac
      901 agatagctct gatgatgagg tttccccccg agagaagcag caaaccaact caaagggcag
      961 cagcaatttc tgtgtgaaga acatcaagca ggcagagttt ggacgccggg agattgagat
     1021 tgcagagcaa gacatgtctg ctctgatttc actcaggaaa cgtgctcagg gagagaagcc
     1081 tttggctggt gctaaaatag tgggctgtac acacatcaca gcccagacag cggtattgat
     1141 tgagacactt tgtgccctgg gggctcagtg ccgctggtct gcctgcaaca tctattcaac
     1201 tcagaatgag gtagctgcag cactggctga ggctggagtt gcagtgtttg cttggaaggg
     1261 cgagtcagaa gatgatttct ggtggtgcat tgaccgctgt gtcaacatgg atgggtggca
     1321 ggctaacatg atcctggatg atgggggaga cttaacccac tgggtttata agaagtatcc
     1381 aaacgtgttt aagaagatcc gaggcattgt ggaagagagc gtgactggtg ttcacaggct
     1441 gtatcagctc tccaaagctg ggaagctctg tgttccagcc atgaatgtca atgattctgt
     1501 taccaaacag aagtttgata acttgtactg ctgccgagaa tccattttgg atggcctgaa
     1561 gaggaccaca gatgtgatgt ttggtgggaa acaggtggtg gtgtgtggct atggtgaggt
     1621 aggaaagggc tgctgtgctg ctctcaaggc ccttggagca attgtctaca tcacagaaat
     1681 tgaccccatc tgtgctctgc aggcctgcat ggatgggttc cgggtggtga agctgaatga
     1741 agtcatccgg caggtggacg ttgtaataac ttgcacagga aataagaatg tagtgacccg
     1801 ggagcacttg gaccgaatga aaaatagttg cattgtatgt aatatgggcc attccaacac
     1861 agaaattgat gtgaccagcc tccgcactcc agagctaaca tgggagcgcg tacgttctca
     1921 ggtggaccat gtcatctggc ctgatggcaa gcgggtcgtc cttctagcag agggtcgttt
     1981 actcaatttg agctgctcca cagttcctac ctttgtcctt tccatcacgg ctacaacaca
     2041 ggctttggca ctgatagaac tttataatgc accagaagga cgctacaaac aggatgtgta
     2101 cttgcttcct aagaaaatgg atgagtatgt tgccagcttg cacctgccat catttgatgc
     2161 ccacctcaca gagctgacag atgaccaagc aaaatatctg ggactcaaca aaaatgggcc
     2221 attcaaacct aattattaca gatactaatg gacgtattac aatgaccagt ccacacgaac
     2281 cacgcaactc taatagagta ttttttaaga taacttttat tttcttctta ttactttcct
     2341 tttgattttt ttttctataa tttcattttt tttctcatct catcatttga gttttgcaga
     2401 ccacacagga acttgctcca tggctgttta ggtgaaactg aggtcaaagg tttctcacct
     2461 ttagtcacta aaaggggtta attctgcagc ccagaaagtc aattctttaa ccatttctgg
     2521 ggactttgat cgcatttagt taccatatta acagaaaatg ctaaggcatc ttctgtgtgg
     2581 aacaatctac agtgtctaaa ttgccttaaa agagactgtt ctagctgctg gaactagtgc
     2641 tctttacttc ttcagaggag ccaggatggc tccagccagg taggttagac gtaggtggtg
     2701 catgtcaact tcccgtagac agacgctcta agccgtttcc tgtctaagat ggcgtgtctg
     2761 cagagatgtg tgctgttaaa ctccgtaggc tcactcggat ttgtagttca gcccttccac
     2821 cagtctctct cattgttcta gttttaacta aactgcattc tatcaagttg aattttgtcc
     2881 cttagcattt atttgttttg tttcttttaa ttaaggaaaa attttagtgt taatcctgag
     2941 gaacagctca ggtggttagt taccaatatc tcttttgaac ctttgaagca aagtgtcaag
     3001 agttgaggct agaaaaatgc tagcctcaga ctctgatgtt tccagctcat agtttatagt
     3061 gtcagtgaac tggagccata agcaaaactt ctcagctctg cctcacgcag cttatgctga
     3121 cggccgattt cttgagccat tactcagtat aaaacactga gccctgtcct tagggtttat
     3181 cctttcagag caaacctgtg ggcagctgtg cttctgcaac ctaaactgtt tgaagggaag
     3241 tttgcataga tggaagaaag aatgacaaat tgggccaagg tgaaacaaat ataactgtat
     3301 aatctgttca gagctggaga ccttgtctgc tgttagtttt atagacatgg tgccactttt
     3361 gattgacact tgccacaaaa atagaaaata aaaattgtaa actgagatct taaagacttg
     3421 gtggagaaag tacatcctga ttcatgctct aagagaattc caagagaccc tctaaaatca
     3481 gagagactta ttcccaggcc acgcacccgc ttgccagcat ctctgcatgg tcaaacgagc
     3541 ttcaagctca agctttaggt atataattat ccgggatttt aagtcctcag cgtgttctag
     3601 cttgtgatcc ttcaaagatg ggttatgtgt taatgataga tactggaaat gtttacttct
     3661 ctctttcact gatcagagaa acaggcatta aaaacagaaa tacaagaaag gaaagctttt
     3721 accctgcacc ttccttgcag ggaacaatta tcttgccaaa acttttttcc ctttcatctc
     3781 ccatttctct gtacccagcc ccttcctgct cctttccaat gtgatcatgc tttcttctct
     3841 atagatacta acatttgaag acccctttcc taaggcactt aaccatccaa tcagaacacc
     3901 acactcagta gggccttatc ttggctaaca gcagtgtatt catctggtca gctctactgg
     3961 agggaagggg ccaagttcct gctgccctct aatctgccct ctggtcctat ctattactgt
     4021 gtccatagga ataataggta agggctagtc tctgtcaagc catgtaacaa aggacactgg
     4081 aaaatgtctg gcatcagagg gaacatttgg agaccaactt gggaggaaaa tattcatttt
     4141 gtattgaatg atttttaatg aatgcaatat taatccttgc agatgagcaa taatcattaa
     4201 agtcaattaa aagtgataag acataa
//
LOCUS       NM_001135814            2526 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus MGAT4 family, member C (Mgat4c), transcript
            variant 1, mRNA.
ACCESSION   NM_001135814 XM_001080664 XM_235099
VERSION     NM_001135814.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001135814.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2633840.1,
                                           SRR26360176.1744583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000007.1  39146882-39147070
            190-239             JAXUCZ010000007.1  39323164-39323213
            240-392             JAXUCZ010000007.1  39346115-39346267
            393-540             JAXUCZ010000007.1  39354954-39355101
            541-2526            JAXUCZ010000007.1  39359103-39361088
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..2526
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="MGAT4 family, member C"
                     /db_xref="GeneID:299756"
                     /db_xref="RGD:1307871"
     exon            1..189
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            190..239
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="upstream in-frame stop codon"
     exon            240..392
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1682
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /EC_number="2.4.1.145"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase C; mannosyl
                     (alpha-1,3-)-glycoprotein
                     beta-1,4-N-acetylglucosaminyltransferase, isozyme C
                     (putative)"
                     /codon_start=1
                     /product="alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase C isoform 1"
                     /protein_id="NP_001129286.1"
                     /db_xref="GeneID:299756"
                     /db_xref="RGD:1307871"
                     /translation="MFKFYQMKYIFQILDKMRCLRKRSTVSFLGVLVVFLLFMNVFIE
                     DSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGTINVTYRYLAATPLQRKRYLT
                     IGLSSVKRKKGNYLLETIKSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKF
                     AHHIIAGRLMVIHAPEEYYPVLDGLKRNYNDPEDRVRFRSKQNVDYAFLLNFCANTSD
                     YYVMLEDDVRCSRNFLTAIKKVIASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFL
                     LMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEES
                     FDIPDNPPASLYTNMNVFENYEASKAYSSVDEYFWGKPPSTGDTFVIVFENPIKIKKI
                     KVNTGTEDRQNDILHHGALDVGEKLIFSKQIRQCETYLRLGEFKNGNFEMSDVNQKIP
                     FDIHCMRICVTKTQKEWLIIRSISIWTS"
     misc_feature    435..1235
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="N-Acetylglucosaminyltransferase-IV (GnT-IV)
                     conserved region; Region: Glyco_transf_54; pfam04666"
                     /db_xref="CDD:461384"
     misc_feature    435..1235
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="N-Acetylglucosaminyltransferase-IV (GnT-IV)
                     conserved region; Region: Glyco_transf_54; pfam04666"
                     /db_xref="CDD:461384"
     exon            393..540
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            541..2526
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggagta cacagaacag ctgaggcagc gttcagtttc agcccgagtg ctattatgat
       61 ggatgtttac atgtcttcat tgagagccaa ttatcttgct tttgtgtgag gcccaaggat
      121 cactcatgct gccaggctgc acagagcact gttggatcta gctgaacgaa ttgtttttct
      181 ctgtctccgg gtgacaatag cttttataca ggacagatta tgtcagcttc tttcttaagg
      241 agaggatgtt taaattttat caaatgaaat atatttttca aatattggat aaaatgagat
      301 gcttgcgaaa acgttctaca gtgtcattct tgggagtcct tgttgttttt cttctattca
      361 tgaatgtgtt cattgaagat agctatgttc tggaaggcga caagcaactt ataagggaaa
      421 catcaacaca tcaacttaat tctgaacgct atgttcatac cttcaaggat ttatcaaact
      481 tctcaggaac tataaatgtc acctatcgct acctggctgc cacaccttta cagagaaagc
      541 gatatctcac aattggactt tcatcagtaa aacggaaaaa aggaaattat ttacttgaga
      601 caatcaagtc aatttttgaa cagtccagct atgaagaact aaaagaaatt tcagttgtag
      661 tgcatctagc agactttaat tcatcatggc gtgatgccat ggtccaagat attacacaga
      721 aatttgccca tcatattatt gcaggaagat taatggttat acatgctcct gaagaatatt
      781 atccagttct ggatggtctt aaaagaaatt acaatgaccc agaagataga gtcagatttc
      841 gctccaagca aaatgtagat tatgcttttc tgctaaattt ctgtgccaat acttctgact
      901 attatgtaat gcttgaagat gatgtccggt gttccagaaa tttcttaact gccatcaaga
      961 aagttatcgc atccttagaa ggaacatact gggtaactct tgagttctct aaacttggct
     1021 acattggaaa actctatcat tctcatgatc tcccacgtct ggcccatttc ttattaatgt
     1081 tttatcaaga aatgccttgt gactggctat tgactcattt ccgagggctg ctggctcaga
     1141 aaaatgtgat tcgatttaaa ccttctctct ttcagcacat ggggtattat tcatcctata
     1201 aaggaacgga gaataaactg aaggatgatg actttgaaga ggagtcattt gacatccctg
     1261 ataacccacc agcaagtctc tacaccaaca tgaatgtctt tgaaaattac gaagcaagca
     1321 aggcttacag tagtgttgat gagtactttt ggggaaagcc accttcaacg ggggatacgt
     1381 ttgttattgt atttgagaat cctattaaaa ttaaaaaaat taaggtgaat actggaacag
     1441 aagaccggca gaatgacatt ttgcatcacg gagccctaga tgttggggaa aaactcattt
     1501 ttagcaaaca aataagacaa tgtgaaactt acttaagact aggggaattc aaaaatggaa
     1561 actttgaaat gtcagatgtg aatcaaaaaa ttccctttga catacattgc atgaggatat
     1621 gtgtcaccaa aactcagaaa gaatggttga taattaggag catcagcatt tggacttcct
     1681 agccaagtaa atcagtagat tgagtttctg aaacaggtct tcctgtttca atttttgcta
     1741 ttccctcttt tgctactttt gtcttttgga gggtaactaa ttggtgtgct gtggcacaag
     1801 aacgttgagt catctcagca gttttgattg tagttttact aagcacatct ttgtaattaa
     1861 tttcacgttt caggctgaat atcattctgt agttaaaact gatttcactc attcatttaa
     1921 atgttcatag ttccaaattt caactcattg tgcaaagagt tgataattta ttttatgttt
     1981 agaaagattc ttagtaagaa tatatgagaa tatgcagatt ggttgccatc ataaaatggg
     2041 atactttttc ttataaattt aggctttcac tgactgatgt atttctacaa ttaatacctc
     2101 ctcatggaag tggtgtcttt acaacagatt agttgtgtaa gtagagcttt gaaaaaacag
     2161 acttaaaagt catcattcct ttggttattt ctatgaaaag gaacattgct cattgtttta
     2221 aaacatttaa ttgagcacat gttaatacaa ttcccatgag aataagtcta tttctaattt
     2281 cccttttgaa aatatatagt taagctcaat attttaaggt tatattggat atctgtaatt
     2341 aatagaggaa gagagatggc ttaccgttag ttcattcata cattttcagt atatgtagaa
     2401 aaaactgaaa ttgatgtttt tactttttgt attaaaactc atgtgattaa aattgttgta
     2461 atttatcata tttggggaag attaaatggc tgtcttatgt gggagaaaag taaaatttaa
     2521 agtaac
//
LOCUS       NM_001437973            2488 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus adaptor-related protein complex 1 associated
            regulatory protein (Ap1ar), transcript variant 2, mRNA.
ACCESSION   NM_001437973 XM_039102717
VERSION     NM_001437973.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Maritzen,T., Zech,T., Schmidt,M.R., Krause,E., Machesky,L.M. and
            Haucke,V.
  TITLE     Gadkin negatively regulates cell spreading and motility via
            sequestration of the actin-nucleating ARP2/3 complex
  JOURNAL   Proc Natl Acad Sci U S A 109 (26), 10382-10387 (2012)
   PUBMED   22689987
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Schmidt,M.R., Maritzen,T., Kukhtina,V., Higman,V.A., Doglio,L.,
            Barak,N.N., Strauss,H., Oschkinat,H., Dotti,C.G. and Haucke,V.
  TITLE     Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin
            KIF5 complex
  JOURNAL   Proc Natl Acad Sci U S A 106 (36), 15344-15349 (2009)
   PUBMED   19706427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039102717.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2014064.1,
                                           SRR26643289.7684.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               JAXUCZ010000002.1  218983138-218983433 c
            297-345             JAXUCZ010000002.1  218967050-218967098 c
            346-372             JAXUCZ010000002.1  218966232-218966258 c
            373-398             JAXUCZ010000002.1  218964489-218964514 c
            399-495             JAXUCZ010000002.1  218960487-218960583 c
            496-551             JAXUCZ010000002.1  218957003-218957058 c
            552-625             JAXUCZ010000002.1  218956302-218956375 c
            626-754             JAXUCZ010000002.1  218955986-218956114 c
            755-2488            JAXUCZ010000002.1  218951104-218952837 c
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2488
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="adaptor-related protein complex 1 associated
                     regulatory protein"
                     /db_xref="GeneID:362037"
                     /db_xref="RGD:1311435"
     exon            1..296
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1017
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="isoform 2 is encoded by transcript variant 2; AP-1
                     complex-associated regulatory protein"
                     /codon_start=1
                     /product="AP-1 complex-associated regulatory protein
                     isoform 2"
                     /protein_id="NP_001424902.1"
                     /db_xref="GeneID:362037"
                     /db_xref="RGD:1311435"
                     /translation="MGNCCWTQCFGLLRREAGRLQRAGGGSKYFRTCPRGEHLTIEFE
                     NLVESDEGESPGSSHRPLTEEEIVDLQERHYDSIAEKQKDVDRKIQREQEKQRIAQRY
                     HPSSGDCQSVGPEDDFEASLRNIKSQYEVFRSSRLSSDATVLTPNTESSCDLMTKTKS
                     TSGNDDSTSLDLEWEDEEGMNRMLPMRERSKTEEDILRAALKCSSKKGSNPTSASDDS
                     NGLEWENDFVSAEMDDNGNSEYAGFVNPVLELSESAIKQSDTDQQIR"
     misc_feature    289..1014
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="AP-1 complex-associated regulatory protein; Region:
                     AP1AR; pfam15745"
                     /db_xref="CDD:464841"
     misc_feature    289..1014
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="AP-1 complex-associated regulatory protein; Region:
                     AP1AR; pfam15745"
                     /db_xref="CDD:464841"
     exon            297..345
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            346..372
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            373..398
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            399..495
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            496..551
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            552..625
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            626..754
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2488
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggtgg caagcaggcc atgcggacgg ctggcgaccc gggaccccac ggccctgcgc
       61 tcgtccctcg cgcccgggta tccaggagcc cgcgggccta gcggcggcct ttgttcccta
      121 catcaccgtc tgccgagctc cggccggcgc ggatgcagct gctccgcctg ggctcgcgct
      181 cggggctgga ggaggagcgg cagctccagg cggcatgcga tggggaactg ctgctggacg
      241 caatgcttcg ggctgctccg ccgggaagcg ggtcggctgc agcgagcggg cggaggatcc
      301 aagtatttta gaacatgccc aagaggagag cacttgacca tagagtttga gaatcttgtg
      361 gagagcgatg agggggagag cccaggaagc agccataggc cacttactga ggaagaaatc
      421 gttgacttac aagagaggca ttatgactct attgctgaga agcagaaaga cgtggatagg
      481 aaaatccaga gggagcaaga aaagcagaga attgcccagc gctatcatcc cagcagtgga
      541 gactgtcaaa gtgtaggacc agaagacgac tttgaagctt ccttaagaaa tataaagtca
      601 cagtatgaag tttttcgaag tagtagactc tcatctgatg ccacagtgtt gacaccaaat
      661 acggaaagca gctgtgacct aatgaccaaa accaaatcaa ccagtgggaa tgacgacagc
      721 acctccttag acctggagtg ggaagatgaa gaaggaatga ataggatgct gcccatgaga
      781 gagcgctcca agacagagga agacatcctg cgggcagcgc tgaagtgcag cagcaagaag
      841 ggcagcaacc ccacgtccgc ctccgatgac tccaacgggc tggagtggga gaacgacttt
      901 gtcagtgccg agatggacga caatggcaat tctgagtacg cggggtttgt gaatcctgtg
      961 ttggaactgt cggagtccgc catcaagcag tctgatacag atcagcagat ccggtagggt
     1021 gaagctgtga ccttactcac caaatgttaa caatcagcta gaatgtacag gtggcacgcc
     1081 agggctcttt gtgagggcag caaaatacca cgtgacagat gcttgttttc ctggagggac
     1141 agctgagtgc tccagttggt gtgagcgcag catctgcctt ctgcgtccca ggactgactc
     1201 agtgattctg acatatcaaa cactcatgcc tttctgttca ccccgtcaag ttctgcatct
     1261 taagtctgca ttcgttttcc tctgaccgct ttactcagcc tatcttccta taacaatcta
     1321 aaagtgtttt tgttagttca gcatatgtac aggcagcatg aggaggtggg gggatcccag
     1381 gaaggcagac ccttccagca gaggctcctt tggttgcttt tactcttctt gtcttgtaga
     1441 cagcaggaat tggagatgac ccaagcatac tgatgtgcgg gcacacacgc gcacacacac
     1501 acacacgcac acacacacac acacacacac acacacacac acatcctaag ccctgcttca
     1561 ctcaatctgg tgacaggatt aaagatgctt ccagagtttg gacactttga gttggtaata
     1621 atgaaaacta atacataaaa atatatattt aaaattttta cttcctttca catgccatta
     1681 tattggcttt aaattgagat tttaagtttt cactttcatt ttttaaaaat tctatatttc
     1741 cagtgagtga tctttgaaag atttttacac agaacatatt ctgtgagtga tttaagaaga
     1801 cattaaaata cgggtatttc aaagtatata acctcctttc tgatatgaaa ggtcccattg
     1861 tattaccctt tccttcgcct tgtagtgcaa ggcgctgtgt gggatggaac taaaatggcg
     1921 gcgtattaaa gacccatgtc tgaatctgta gagaaggcca gggctgggaa gtgtttccta
     1981 actgcgttcc ttgctttggc tgaggactga gtgtcacttt gggaagcaca cggcattctg
     2041 tctcccttgc tgttttcctc tcctcagcag cgatggtgca tgctttcagc agtacagggc
     2101 ggtcaggtag aaatagtcaa gttcttgctg tgcgtgaaaa cttatgtggc cctttcaata
     2161 tttgaactgc tatacgatga catctataat tttgtcattt ttaaatctca tacaaataaa
     2221 tatactttga tatgtaaata tgcattaggt tatgctatta tttatatcta tcttaagatt
     2281 taaattgtag gtgtgtcatg gaaataattt aaaggcactc tgttcacatt gcctgtgttc
     2341 atgctttcta aggtttatat tacatcagat gtatattttt ggtttggcat aagctactgt
     2401 tgtaattttc ttggcttttt gttcataaag aattttctga aggaatggta acctttcaag
     2461 gattgtgaat aaacattttt acaattaa
//
LOCUS       NM_001024798            4083 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 1, mRNA.
ACCESSION   NM_001024798 XM_342284
VERSION     NM_001024798.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4083)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 4083)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 4083)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 4083)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4083)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4083)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 4083)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001024798.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000002.1  177791555-177791637 c
            84-213              JAXUCZ010000002.1  177786942-177787071 c
            214-291             JAXUCZ010000002.1  177784108-177784185 c
            292-402             JAXUCZ010000002.1  177782701-177782811 c
            403-571             JAXUCZ010000002.1  177779310-177779478 c
            572-667             JAXUCZ010000002.1  177778834-177778929 c
            668-713             JAXUCZ010000002.1  177775282-177775327 c
            714-826             JAXUCZ010000002.1  177774722-177774834 c
            827-886             JAXUCZ010000002.1  177771737-177771796 c
            887-939             JAXUCZ010000002.1  177768704-177768756 c
            940-1025            JAXUCZ010000002.1  177766872-177766957 c
            1026-1197           JAXUCZ010000002.1  177765163-177765334 c
            1198-1396           JAXUCZ010000002.1  177760418-177760616 c
            1397-1674           JAXUCZ010000002.1  177758391-177758668 c
            1675-1847           JAXUCZ010000002.1  177758048-177758220 c
            1848-2037           JAXUCZ010000002.1  177756072-177756261 c
            2038-2092           JAXUCZ010000002.1  177755325-177755379 c
            2093-2267           JAXUCZ010000002.1  177753749-177753923 c
            2268-2340           JAXUCZ010000002.1  177753274-177753346 c
            2341-2536           JAXUCZ010000002.1  177751968-177752163 c
            2537-2625           JAXUCZ010000002.1  177751792-177751880 c
            2626-2679           JAXUCZ010000002.1  177749533-177749586 c
            2680-2761           JAXUCZ010000002.1  177747255-177747336 c
            2762-2979           JAXUCZ010000002.1  177746302-177746519 c
            2980-3085           JAXUCZ010000002.1  177745433-177745538 c
            3086-3153           JAXUCZ010000002.1  177740434-177740501 c
            3154-3351           JAXUCZ010000002.1  177739078-177739275 c
            3352-3402           JAXUCZ010000002.1  177738613-177738663 c
            3403-4083           JAXUCZ010000002.1  177736374-177737054 c
FEATURES             Location/Qualifiers
     source          1..4083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4083
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..83
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..213
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             124..3441
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 1"
                     /protein_id="NP_001019969.2"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGT
                     KSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGSSS
                     GNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGAWRTATEEWGTEDWNEDLSET
                     KIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPSLAQPL
                     VFSNSKQNAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQAL
                     AQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFTPSSTM
                     MEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQ
                     KKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAP
                     SSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPS
                     SISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSESPSTSSIPSLNETVPA
                     ASLLTTASQHSSSLSGLSHSEEIPNTTTTQHSSALSTQQNTLSSSTSSGRTSTSTLLH
                     TSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRS
                     SVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYS
                     IPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQ
                     QTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASAT
                     PFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLP
                     SALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQLPYLQMILCCQR
                     QQEEQDILTLVDDQLGE"
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1669..1752
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1669..1752
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            214..291
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..402
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..571
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..713
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..826
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..886
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..939
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1025
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1197
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1396
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1674
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1847
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2037
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2092
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2267
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2340
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2536
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2625
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2679
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2761
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2979
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3085
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3153
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3351
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3402
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..4083
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgaggt aaagttggca gcgcagcggc gttggcggcg gcggcggcgg
       61 cagcggcaac gcggcggggc cggtattctt ccttgtaaat actgttattt gtatatactg
      121 taaatgatga cgtcggtggg cactaaccga gcccggggaa actgggaaca acctcaaaac
      181 caaaaccaga cacagcacaa gcagcggcca caggccactg cagagcaaat tcgacttgca
      241 cagatgattt cggaccataa tgatgctgac tttgaggaga aggtgaaaca attgattgat
      301 atcacaggca aaaaccagga tgaatgtgtg attgctttgc atgactgcaa tggagatgtc
      361 aacagagcca tcaatgttct cctggaagga aatccagaca cgcattcctg ggagatggtc
      421 gggaagaaga aaggagtctc aggacagaag gatggtggac aaactgaatc taatgaagaa
      481 ggaaaagaaa atcgagaccg ggacagagac tatagtcgac gacgtggtgg gccaccaaga
      541 cgggggagag gtgccagccg tggacgagag tttcggggcc aggaaaatgg attggatggc
      601 actaagagtg gtggaccttc tggaagaggc acagacagag ggagaagagg ccgtggccgg
      661 ggcagaggta gttctggtag acgaggagga aggttttctg ctcaaggaat gggaaccttt
      721 aaccctgctg attatgcaga gccagccaac actgatgata actatggcag tagcagtggc
      781 aatacatgga acaacactgg ccactttgaa ccagatgatg gaacaagact tgatttcatt
      841 ggggttgagg ggtcaaatta tccccgaaaa tttgagactg ctcctggtgc atggaggact
      901 gcaacagaag agtggggaac tgaagattgg aatgaagatc tttctgagac caagatcttt
      961 actgcctcta atgtgtcttc agtgcctctg cctgcggaga atgtgacaat cactgctggt
     1021 cagagaattg atcttgctgt tctgttgggg aagacaccgt cttcaatgga gaatgattca
     1081 tctaatctgg atccatctca ggctccttcc ctggcccagc ctctggtatt cagtaattcg
     1141 aagcagaatg ccatatcaca gcctgcttca gggaatacat tttctcatca tagcatggtg
     1201 agcatgttgg ggaaaggatt tggtgatgtt ggggaagcta aaggtggcag tacaacaggc
     1261 tctcagttct tggagcaatt caagactgca caggccctgg ctcaactggc agctcaacat
     1321 tctcagtctg gaagcaccac cacctcctct tgggatatgg gctcaacaac acaatcacca
     1381 tcactggtgc agtatgattt gaagagtgca aatgattcaa cagtgcacag tccttttaca
     1441 aagcgccagg cattcacccc atcatcaacc atgatggagg tgttccttca ggagaagcca
     1501 cctgcagtgg ctacctcgac agctgcacct cctcccccct cttctcctct gccaagcaaa
     1561 tccacctcgg ctccacagat gtctccgggg tcttcggaca accaatcctc cagccctcag
     1621 ccggctcaac agaaactgaa acagcaaaag aagaaaacct ccttgacgtc taagattcct
     1681 gctctggctg tggagatgcc tggctcagca gatatctcag ggctaaatct gcagtttggg
     1741 gcattgcaat ttgggtcaga gcctgtcctt tctgattatg agtccacccc caccacgagc
     1801 gcctcttcaa gccaggctcc cagtagcctg tataccagca cggccagtga gtcttcatct
     1861 acagtttcat ctaatcagag tcaggagtct ggttatcaga gtggcccaat tcagtcgaca
     1921 acttatacct cccaaaataa tgctcagggc cctctatatg aacagagatc cacacagaca
     1981 cggcggtatc ccagctccat ctcttcatca ccccaaaagg acctgactca ggctaagaat
     2041 ggtttcagct ctgtgcaggc cacgcagtta cagaccacgc aatctgttga aggtgctaca
     2101 ggctctgcag tgaaatctga atcaccttcc acttctagta taccctctct caatgaaaca
     2161 gtacctgcag cttccttact gacgacagcc agtcagcatt catcctcctt aagtggcttg
     2221 agccatagtg aggagattcc aaataccacc accacacaac atagcagtgc attatctaca
     2281 cagcagaata ccctttcttc atcaacatct tctgggcgta cttcaacatc tactcttttg
     2341 catacaagtg tggagagtga agcgaatctg cattcttcct ccagcacttt ctctaccacg
     2401 tccagcactg tctctgcacc tcccccagtg gtcagtgtct cctccagtct gaatagtggc
     2461 agtagcctgg gccttagcct gggcagcaac tctactgtca cagcctcaac tcgaagctca
     2521 gttgctacaa cttcaggaaa agctcctccc aaccttcctc ctggagtccc gccattgttg
     2581 cctaatccat atattatggc tccagggctg ttacatgcct acccgccaca agtatatggt
     2641 tatgatgatt tacagatgct ccagacaaga tttccattgg attactacag tatcccgttt
     2701 cccacaccca ccactccact tactgggagg gatggtagcc tggccagcaa cccttactct
     2761 ggcgacctca ccaagttcgg ccgcggggat gcctcctccc cagccccagc cacaaccttg
     2821 gcccaacccc aacagaacca gacgcagact caccacacca cgcagcagac attcctgaac
     2881 ccggcgctgc ctcctggcta tagttacacc agcctgccat actacacagg ggtcccgggc
     2941 ctccccagca ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag
     3001 cagcatggtg tgaatgtcag tgtgaatgcc tcggccaccc ctttccaaca accaagtgga
     3061 tatgggtctc atggatacaa cactggtgtg tcagtcacct ccagtaacac gggcgtgcca
     3121 gatatctcgg gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat
     3181 tccggtactc ctgctgcctc cttcaacttg ccttcagccc taggaagtgg agggcccatc
     3241 aatccagcca cagctgctgc ctacccacct gcccccttta tgcacattct gaccccacat
     3301 cagcagccac actctcagat ccttcaccat cacctgcagc aggatggcca gctaccatat
     3361 ttgcagatga ttctctgttg ccagcgccag caggaggagc aggatatcct cactctcgtc
     3421 gatgaccagc ttggtgaata agtattaccg taccaactgg gcctcttcta gcaggctcga
     3481 aggctgtgga ataaagtgaa atctttgccc tttaagaact ctcaccttaa tgtgctaata
     3541 ttttgccctt aaggggattc ccttttacat cctgtgactg aaaagaacca ctgcacatct
     3601 tcatttcttc tagaaactgc ctcacctaca gcaagtttca ggaagtgaaa ggggaaggag
     3661 ctaaggacat ttaaaaggaa aaggaccttg tgggaatcta agcatgattt aaaggattct
     3721 gaaatctgaa gccagcatta tctactgtct ggcagaacca aattgtaggg cttttttctt
     3781 tttggaggag tatagtagtt cttgtctgag ttatgttttt gagacaatct cactatgtaa
     3841 ccctgactgg ctagaagttg taacccaact ggctggaagt tggtgtggag accaggctgg
     3901 tctcaaattc agagatctac ctgcctctac ctcttgagtg ccaaggttaa aggttctcag
     3961 cactatacct taccttgcct tttttatgtg actttgaaat gcctaagttt tgggaaagga
     4021 gtggatgatg gtagagcaag acctggggtg gggacatggt gcagtaaaag gttttggaca
     4081 tgg
//
LOCUS       NM_001437903            4228 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 9, mRNA.
ACCESSION   NM_001437903 XM_063263338
VERSION     NM_001437903.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4228)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263338.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.31379.1,
                                           SRR26643295.29803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-312             JAXUCZ010000007.1  122187562-122187662
            313-468             JAXUCZ010000007.1  122194723-122194878
            469-551             JAXUCZ010000007.1  122198007-122198089
            552-599             JAXUCZ010000007.1  122198472-122198519
            600-842             JAXUCZ010000007.1  122203808-122204050
            843-1029            JAXUCZ010000007.1  122207498-122207684
            1030-1167           JAXUCZ010000007.1  122210547-122210684
            1168-1233           JAXUCZ010000007.1  122213276-122213341
            1234-1346           JAXUCZ010000007.1  122216165-122216277
            1347-1460           JAXUCZ010000007.1  122216625-122216738
            1461-1587           JAXUCZ010000007.1  122218925-122219051
            1588-1740           JAXUCZ010000007.1  122220112-122220264
            1741-1956           JAXUCZ010000007.1  122223641-122223856
            1957-2021           JAXUCZ010000007.1  122225088-122225152
            2022-2137           JAXUCZ010000007.1  122226909-122227024
            2138-2223           JAXUCZ010000007.1  122228286-122228371
            2224-2321           JAXUCZ010000007.1  122229298-122229395
            2322-2379           JAXUCZ010000007.1  122229728-122229785
            2380-2501           JAXUCZ010000007.1  122230077-122230198
            2502-2665           JAXUCZ010000007.1  122230444-122230607
            2666-2822           JAXUCZ010000007.1  122231523-122231679
            2823-2911           JAXUCZ010000007.1  122231770-122231858
            2912-3107           JAXUCZ010000007.1  122232571-122232766
            3108-3335           JAXUCZ010000007.1  122235416-122235643
            3336-4228           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4228
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..312
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..468
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..551
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    529..531
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            552..599
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..842
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..3384
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 2 is encoded by transcript variant 9;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 2"
                     /protein_id="NP_001424832.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLAFSEYQIQQMTANFVDQFGFNDEEFADQDD
                     NINAPFDRIAEINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARV
                     MARARFGAPHTSENYSKKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDS
                     AGTTWTAVFDEPVNPLSAASGAARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETG
                     PRCSSPVDMDHSNAEGGQSPGPEKAFGPTSPCAWNVCVTRKAPLVASDSSSSGGSDSE
                     DDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRAECPDSTVLAPACPAPSEVTISPAV
                     ATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAIVATLGTMTKDRKTDALPD
                     GAALNGPV"
     misc_feature    997..2217
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    997..2217
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2467..>3354
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2467..>3354
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            843..1029
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1167
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1233
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1346
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1460
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1587
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1740
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1956
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2021
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2137
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2223
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2321
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2379
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2501
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2665
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2822
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2911
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3107
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3335
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..4228
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggttctcagc cttggctgtc ctggaactct
      241 ctccatagac caggcgggcc ttgaactcat agagatctgc ctacctctgc ctcctgagtg
      301 ctgagatcaa agtctctacc acagcgcgtt ctgttggact ctttcacgga actataggat
      361 cacatgggca gcacttgtgt ttgattctac cctctttctt ccggtcggtt ctgtcaccct
      421 gggaaataga gaagcagaac gtacggctcc tttcttcatt cactgctgga tcaatgtcca
      481 gggccaaggc agttttgttt gtgtggattt ctgtttactg ctgcatggta gaggctgccg
      541 aaccccataa ggaaacattg ttgcggtttg cacatccagt ctgagagact tctgcattgc
      601 tctgtgacca ccatcatgtt ctggaaattt gacttgaata ccacgtccca cgttgacaag
      661 ctcctcgaca aggaacatgt gacactgcag gaattaatgg atgaagatga catcttgcaa
      721 gagtgtaagg ctcagaacca gaagctgctg gacttcctgt gcaggcagca gtgtatggag
      781 gagctggtga acctcatcac acaagaccca ccccaggaca tggaagagaa ggtccgattc
      841 aaatatccaa acacagcctg tgagcttctg acttgtgatg tgccgcagat cagcgacaga
      901 ctaggcgagg acgagagtct gctgaacctt ctgtatgact tcttggacca ggagccacca
      961 ctcaaccctc tgcttgccag tttttttagc aagaccattg gcaatctcat tgcaaggaaa
     1021 accgaacagg tgatcatgtt cttgaagaag aaggacaagt tcatcagtct gatactgaag
     1081 cacataggca cctcagctct catggacctg ctgctacgcc tggtcagctg cgtggaacca
     1141 gttgttctcc ggcaggaggt cctacattgg cttaatgaag agaaagtcat ccagagactt
     1201 gtggaattga tccatcccca ccaggatgaa gataggcagt caaatgcttc tcaggcactc
     1261 tgtgacatca tcaggctggg cagagaccag ggcagtcagc tgcaggagac tgtggagccg
     1321 gatcccctcc tcacagcact ggagtcgcag gactgtgtgg aacagcttct gaagaacatg
     1381 tttgatgggg atcggacgga gagctgcctg gtcagtggga tgcaggtgct gcttgccctg
     1441 ctggagccaa ggcgtgttgg aacagaaggc ttggtggact ccttttctca gggactggaa
     1501 aggtcatact ctgtcagcag cagcatcctg cacggcattg agccatggct gaagaatttc
     1561 catcagctcc tgctcaaccc accaaagaag aaagcaatcc tgaccactat tggcgtgcta
     1621 gaggagcccc tggggaatgc tcgtcttcat ggtgcacgcc tcatggctgc actgctgcac
     1681 acaaatacgc ccagcatcaa ccaggagctc tgccggctca acaccatgga cttactgctg
     1741 gacctgtttt ttaagtacac ctggaataac ttcttacact tgcaagtgga gctgtgcata
     1801 gccgctattc tctcccacgc tggtcgggag gagcaggcag aagctggcag atcagatggc
     1861 aaagtggaac ctgtgcaggg gagtggagat gggggtggga agccggagac caccccgtcc
     1921 atcaccagcc ctcctgagaa cacaatggtg acccatctgt tccagaagtg ctgcctggtt
     1981 cagaggatcc tggaagcctg ggaagccaat gacaacacac aggcggcagg tggcatgaga
     2041 cgtgggaata tgggccacct cacaaggatc gccaacgcag ttgtacagaa cctggagcag
     2101 ggcccggtgc agacacacat cagtgaagtc atccgagggc tccctgcaga gtgccgtgga
     2161 cgctgggaga gctttgtgga agagacactg atggagacca accgcaggaa cactgtggac
     2221 ctggccttct ctgagtacca gatccagcag atgacagcaa actttgtgga tcagtttggc
     2281 ttcaatgatg aggagtttgc agaccaggat gacaacatca atgccccatt tgaccggatt
     2341 gcagagatca acttcaacat tgaagccgat gaggacagtc ccagtgcagc tctgtttgaa
     2401 gcttgctgca gtgatcggat ccagcccttc gatgatgacg aggaggacat ttgggaggat
     2461 gaggagactc gatgcacggc ccgggtgatg gccagagcca ggtttggagc ccctcacacc
     2521 tcagaaaact actcaaagaa ggccgtggga catggaggcc agggcaggaa gactggctcc
     2581 cccacagcta ggaatgtgcc tggactggcc acgccttcat cccctacaca gaaagaaggt
     2641 cctcgctcag aaagtgattc agcaggtact acatggacag cagtttttga tgagccagtg
     2701 aacccgctgt ctgcagcctc aggagctgcg agggatgtgg gttctagtgc atgggcggct
     2761 ggtccttcag ttgcagagga gaaaggctgg gccaaattca ccgacttcca gcctttctgc
     2821 tgctctgaga cagggccccg gtgcagctct cctgtggaca tggaccacag caatgccgag
     2881 ggtggccaga gtccaggccc agagaaagcc tttggtccta cctcgccttg tgcctggaac
     2941 gtgtgtgtca ctaggaaggc cccactggta gcctctgaca gcagctcctc tgggggatct
     3001 gacagtgaag atgacgagaa ggcagcgggt gctgtggaag ctctgtgcgc aggccatact
     3061 ggaaaggcct ccccgccacc caggacagca gaggctgctg ctggcagggc cgagtgtcct
     3121 gacagcaccg tgttagcccc tgcctgccct gctccttcag aagtgaccat cagtcctgcc
     3181 gtggctacca tagcaccaag caaggcaggc tctcccacag ccaccatagt ggtctcttcc
     3241 tcagtggcta ctgcggtacc cccaggacca atcatggcag taaccacaac agctccagcc
     3301 atagttgcaa ccctggggac aatgacaaag gacaggaaga cagatgccct gccagatgga
     3361 gctgccttaa atggccctgt gtaatggctg ccgcccagct atggcccacc ctggtcaggc
     3421 tgcctcctta atcaagaaga ctacctggtg atgcaatttt ttttaattta actttaaaat
     3481 aaatgctgca tttggtaaag ctggcagtgg aacccgttgg atgacccagc tcatgtttct
     3541 cctgcctgcc cttggtcctg ttggaggaca ggatgcacct ggccattccc aggcccaggt
     3601 cttggtgtgg caatgcagcc ctgacgcgca gcttcaacct gcaggagttg gggagggaac
     3661 aagaccctaa ggggccagca ccatcggatg ggcaggaagg gtgcggatct ccaggcgctg
     3721 gtttcatctg tatttttaac gcatggagga aaagccgttt tttgcacttt gtacccagct
     3781 acagtacagg gtctctctag gctcagggca gatgtacagg cctgagttgg agagacctga
     3841 tccccactaa taatactaca tgggggtctg gcactagttt ggccacatga ggtcaaaccc
     3901 cagttctagc tgcccaggga ctcctgggag ctggtgttga atcaggctac acattttgac
     3961 tgccttaaaa acaaagaccc tctggacccg gtgcagtggt ctctgtgctc agcagggcag
     4021 actggcacac tcgggtgggg gttggagctg caccagacat gtaagagtgg acacggaaga
     4081 gcactgggag gcctagggac cgggcgggcc catagtgtcc aggaagagtc taaagtctat
     4141 gttgtctttt tttttttttt tttttaaatg ttctgacctt ctgacagggc atctaacccc
     4201 caataaaaag gatcattctt actgaaaa
//
LOCUS       NM_001105759            7635 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 4, mRNA.
ACCESSION   NM_001105759 XM_001078910 XM_224538
VERSION     NM_001105759.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7635)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7635)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7635)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7635)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7635)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001105759.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               JAXUCZ010000015.1  105289555-105289948 c
            395-511             JAXUCZ010000015.1  105182942-105183058 c
            512-601             JAXUCZ010000015.1  105168842-105168931 c
            602-684             JAXUCZ010000015.1  105162379-105162461 c
            685-754             JAXUCZ010000015.1  105160417-105160486 c
            755-850             JAXUCZ010000015.1  105158803-105158898 c
            851-985             JAXUCZ010000015.1  105157736-105157870 c
            986-1160            JAXUCZ010000015.1  105151440-105151614 c
            1161-1228           JAXUCZ010000015.1  105149491-105149558 c
            1229-1303           JAXUCZ010000015.1  105137132-105137206 c
            1304-1444           JAXUCZ010000015.1  105135597-105135737 c
            1445-1642           JAXUCZ010000015.1  105134347-105134544 c
            1643-1765           JAXUCZ010000015.1  105133869-105133991 c
            1766-1848           JAXUCZ010000015.1  105129765-105129847 c
            1849-1971           JAXUCZ010000015.1  105129126-105129248 c
            1972-2051           JAXUCZ010000015.1  105124162-105124241 c
            2052-2239           JAXUCZ010000015.1  105123885-105124072 c
            2240-2305           JAXUCZ010000015.1  105123662-105123727 c
            2306-2398           JAXUCZ010000015.1  105122343-105122435 c
            2399-2522           JAXUCZ010000015.1  105120141-105120264 c
            2523-2644           JAXUCZ010000015.1  105119666-105119787 c
            2645-2731           JAXUCZ010000015.1  105118736-105118822 c
            2732-2821           JAXUCZ010000015.1  105117931-105118020 c
            2822-2937           JAXUCZ010000015.1  105115724-105115839 c
            2938-3007           JAXUCZ010000015.1  105113993-105114062 c
            3008-3133           JAXUCZ010000015.1  105113031-105113156 c
            3134-3205           JAXUCZ010000015.1  105111200-105111271 c
            3206-3352           JAXUCZ010000015.1  105101578-105101724 c
            3353-3436           JAXUCZ010000015.1  105101310-105101393 c
            3437-3548           JAXUCZ010000015.1  105100567-105100678 c
            3549-3727           JAXUCZ010000015.1  105098660-105098838 c
            3728-3841           JAXUCZ010000015.1  105098365-105098478 c
            3842-3959           JAXUCZ010000015.1  105096851-105096968 c
            3960-4093           JAXUCZ010000015.1  105091621-105091754 c
            4094-4205           JAXUCZ010000015.1  105089536-105089647 c
            4206-4272           JAXUCZ010000015.1  105087183-105087249 c
            4273-4320           JAXUCZ010000015.1  105085955-105086002 c
            4321-4364           JAXUCZ010000015.1  105082924-105082967 c
            4365-4480           JAXUCZ010000015.1  105076918-105077033 c
            4481-4618           JAXUCZ010000015.1  105074536-105074673 c
            4619-4801           JAXUCZ010000015.1  105074236-105074418 c
            4802-4915           JAXUCZ010000015.1  105072671-105072784 c
            4916-5131           JAXUCZ010000015.1  105072316-105072531 c
            5132-5189           JAXUCZ010000015.1  105069893-105069950 c
            5190-5296           JAXUCZ010000015.1  105067917-105068023 c
            5297-5419           JAXUCZ010000015.1  105053003-105053125 c
            5420-5533           JAXUCZ010000015.1  105051698-105051811 c
            5534-5680           JAXUCZ010000015.1  105050156-105050302 c
            5681-5891           JAXUCZ010000015.1  105046980-105047190 c
            5892-6082           JAXUCZ010000015.1  105035414-105035604 c
            6083-6183           JAXUCZ010000015.1  105031777-105031877 c
            6184-6322           JAXUCZ010000015.1  105031234-105031372 c
            6323-7635           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7635
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..394
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..6445
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 4 is encoded by transcript variant 4;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 4"
                     /protein_id="NP_001099229.2"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MAQQQLPVSTETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAK
                     PKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEE
                     EAQSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADK
                     DEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKD
                     EKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLN
                     KILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESR
                     VKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTN
                     VEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQ
                     AAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNA
                     KQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADF
                     RKPEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVP
                     CIPKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIY
                     GRPGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKG
                     STKKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEV
                     KWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAM
                     EGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKF
                     AYKAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHL
                     IENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRC
                     FTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGR
                     IQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSF
                     DDRYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGN
                     PLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSL
                     PDRNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWN
                     KASTAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVAHQS
                     LLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMA
                     LKNVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMR
                     NNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTS
                     FSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMA
                     RIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVG
                     MQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTL
                     HRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLL
                     KLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCH
                     NIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIE
                     VAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKR
                     YPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMR
                     EQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV"
     misc_feature    401..733
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    401..733
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    773..1144
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    773..1144
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2174..2743
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2174..2743
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    5066..6310
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    5066..6310
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5378..5380,5408..5410,5414..5419,5423..5428,
                     5435..5440,5444..5449,5456..5461)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5378..5380,5408..5410,5414..5419,5423..5428,
                     5435..5440,5444..5449,5456..5461)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5480..5491,5495..5497,5582..5587,5591..5602,
                     5606..5611,5666..5674,5723..5725,5729..5731,5816..5818,
                     5822..5824,5843..5848,5864..5866,5981..5986,5993..5995,
                     6035..6037,6041..6043,6053..6055,6062..6070,6077..6088,
                     6092..6097,6104..6106,6188..6190,6242..6247,6251..6256,
                     6263..6265)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5480..5491,5495..5497,5582..5587,5591..5602,
                     5606..5611,5666..5674,5723..5725,5729..5731,5816..5818,
                     5822..5824,5843..5848,5864..5866,5981..5986,5993..5995,
                     6035..6037,6041..6043,6053..6055,6062..6070,6077..6088,
                     6092..6097,6104..6106,6188..6190,6242..6247,6251..6256,
                     6263..6265)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    6077..6094
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    6077..6094
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            395..511
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            512..601
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            602..684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            685..754
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            755..850
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            851..985
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1160
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1228
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1303
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1444
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1642
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1765
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1971
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2051
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2239
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2305
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2398
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2522
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2644
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2731
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2821
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2937
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3133
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3205
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3352
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3436
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3548
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3727
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3841
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..3959
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4093
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4205
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4272
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4320
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4364
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4480
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4618
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4801
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..4915
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..5131
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5189
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5190..5296
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5419
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5533
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5680
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5681..5891
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5892..6082
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6183
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6184..6322
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6323..7635
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggcggc cgagcacgga ggtcgggggc atgggggagc cgcggcgggt gctacgcgga
       61 ggatcgtccc gagcgaggcc aggcgccgcc gcaggcatac ggatccgggg aagacacctc
      121 ggggcgtgac gcggcacaga gggcgtggcc cgggctgcag tgcctgacga cccggcaggg
      181 accgggggtt cccgtgcccg gggcgcacct ggcggcggcg cgaccgggcc ggaccgcgcg
      241 gtccgaagcc cgcagcggcg gccggaggat ggcgcagcag caactccctg tgtcgacgga
      301 gactcggaag ttcacccggg cgttgagcaa gcccggcacg gcggcggagc tgcggcagag
      361 tgtgtcggag gtggtgcgcg gctcggtgct cctggcaaag ccaaagctga ttgagccact
      421 tgactacgaa aatgtcatcg tgcagaagaa gacccagatc ctgaatgact gtctgcggga
      481 gatgctcctc ttcccttacg atgacttcca gacggccatc ctgaggcggc aggggcgcta
      541 cgtacgttcc acggtccctg caaatgcaga ggaggaagca cagagcctgt ttgtcaccga
      601 gtgcatcaaa acctacaact ctgactggca ccttgtgacc tatcactatg aagattactc
      661 aggagagttc cgacagcttc caaacaaagt ggccaagttg gataaacttc cagttcacgt
      721 ctatgaagtc gatgaggagg ctgacaaaga tgaggacgct gcttcccttg ggtctcagaa
      781 gggtggaatc acaaagcacg gctggctgta caaaggcaac atgaacagtg ccatcagcgt
      841 gaccatgagg tcattcaaga ggcggttttt ccacctgatt cagcttggcg atggatccta
      901 taatctaaac ttttataaag atgagaagat ctccaaggag ccgaaagggt ccatattcct
      961 ggattcctgc atgggcgtga tccagaacaa cagagtcagg cgcttcgcct ttgagctcaa
     1021 gatgcaggac aaaagcagtt accttctggc tgcggacagt gaggcagaga tggaggagtg
     1081 ggtcacagtc ctcaacaaga tcctccagct caactttgag gctgcaatgc aagagaagcg
     1141 aaatggggac cctcatgaag atgatgaaca aagcaaactg gaaggttccg gttccggttt
     1201 ggacagctac ctgcctgaac ttgccaagag caccagagaa gcagaaatca aactgaaaag
     1261 cgagagcaga gtgaagctct tttacttgga cccagatacc cagaaactcg acttctcatc
     1321 tgctgaacca gaagtgaagc catttgaaga aaagtttggg aagaggattc tcgtcaagtg
     1381 caatgatttg tccttcaacc tgcagtgctg tgtcgcagag aacgaggaag gacccacgac
     1441 aaatgtggag cctttctttg tcaccctgtc cctgttcgac ataaaataca accggaagat
     1501 ttctgctgac ttccacgtgg acctgaacca cttctcagtg cggcagatgc tggcccctgc
     1561 atccccagtg ctgatgaacg gtggtcagag tccacctgcc ttccaggatg cccttcaggc
     1621 ggccatgcag tatccgaagc agggaatatt ttcagtcacg tgtcctcacc cagacatatt
     1681 tcttgtggcc agaattgaaa aggtcctcca aggaagcatc acgcactgtg ctgagcctta
     1741 catgaaaagc tcagactctt ctaaggtcgc tcagaaggtg ctgaagaatg ccaagcaggc
     1801 atgtcaaaga ctaggacagt accgaatgcc gtttgcttgg gcagcaagga cgttgtttaa
     1861 agacacatct ggaaacctgg ataaaaatgc caggttttct gccatctacc ggcaagacag
     1921 caataagctc tcaaatgagg acatgctcaa gctgctcgca gacttccgga aacctgagaa
     1981 gatggccaaa ctcccagtga ttttaggcaa tctagacatt acaatcgaca acgtttcctg
     2041 cgacttccct aattacctga attcatcata cattcccatg aggcagtttg aaacctgcag
     2101 taagtctccg atcaccttcg aagtagagga gtttgtgccc tgcataccca agcacaccca
     2161 gccttataca gtctacagca atcaccttta tgtttacccc aagtacttga gatacgacag
     2221 ccagaagtct tttgccaagg ccagaaacat tgcaatctgc attgagttca aggattccga
     2281 tgaagaagac tcgcaaccct tgaagtgcat ttacggcaga cctggtggcc cagtgttcac
     2341 aaggagtgcc ctcgctgcag tcctacacca tcaacaaagc ccagaattct acgatgagat
     2401 caagatagag ctgcccgccc agctgcacga gaagcaccat ttactgttca ccttcttcca
     2461 cgtcagctgc gacaactcga ccaaagggag cacgaagaag aaggacgctg tggagacaca
     2521 ggttggcttc tcctggcttc ctctcctgaa agacggcaga gtgttgacga atgaacagca
     2581 tatccctgtc tccgccaacc tgccgtctgg ctaccttggc taccaggagc tcagcatggg
     2641 caggcattat ggtccagaag ttaagtgggt ggaaggaggc aagccattgt tgaaaatctc
     2701 cactcatctg gtttccaccg tgtacactca ggatcagcac ttacacaatt ttttccaata
     2761 ctgtcagaaa acggaatctg gagcccaagc ctcagggagt gaactagtga aataccttaa
     2821 gagtctgcat gcaatggaag gtcacgtgat gatcgccttc ctgccgacca ttttaaacca
     2881 gctattccga gtcctcacca gagccaccca ggaggaggtt gcagttaatg tgactcgggt
     2941 cattattcat gtggttgccc agtgccatga ggaaggattg gagagccact tgaggtcata
     3001 tgttaagttt gcctacaagg ctgagccgta tatagcatcc gagtataaga cagtgcacga
     3061 ggaactgacg aaatccatga ccaccattct caagccttct gctgatttcc ttaccagcaa
     3121 caaacttctg aagtactctt ggtttttctt tgatgtgctg ataaagtcca tggctcagca
     3181 tttgattgaa aataacaaag tgaagttact tcgaaaccag agatttccgg cctcctacca
     3241 tcacgccgtg gaaaccgtgg tgaacatgct gatgccgcac atcacacaga agtttcgaga
     3301 taacccagaa gcatctaaga atgccaatca cagcctggcc gtgttcatca agagatgctt
     3361 caccttcatg gacagaggct tcgtcttcaa acagatcaac aactacatca gttgctttgc
     3421 tcctggagac cccaagactc tctttgagta caagtttgag tttctccgtg tggtgtgcaa
     3481 ccatgaacac tatattcctt tgaacttgcc gatgccattt gggaaaggaa gaattcagag
     3541 ataccaagat ctccagcttg actactcttt aacggacgaa ttctgcagaa accacttctt
     3601 ggtgggactg ttactaaggg aggtgggtac tgcactccag gagttccggg aggtccgtgt
     3661 catcgctgtc agtgtgctca agaaccttct gatcaagcat tcttttgatg acagatacac
     3721 ttcaaggagt caccaggcaa ggatagccac cctctacctg cctctgtttg gtctgcttat
     3781 tgaaaacgtc cagcggatca acgtgaggga tgtgtcgccc ttccctgtga acccgggcag
     3841 tatctcgaag gacgaagccc tggccgtgcc taccgggaat ccactcatga ctccgcagaa
     3901 gggaaacaca cttgaccaca gcctgcacaa agacctcttg ggtgccatct ccggcattgc
     3961 ttctccgtat acagcttcaa cccccaacat caacagtgtg agaaatgccg actcaagggg
     4021 ctctctcatc agcacggact cggggaacag ccttccagac aggaaccccg agaagagcaa
     4081 ctccctggac aagcagcaga gcggcatgct gggaaattct gtggtccgct gtgacaaact
     4141 ggaccagtct gagatcaaga gcctgctgat gtgcttcctc tacgtgttga agagcatgtc
     4201 tgacgatgcc ctgtttacgt actggaacaa ggcttccact gctgaactga tggatttctt
     4261 taccatatct gaagtgtgcc tgcaccagtt ccagtacatg gggaagcgct acatagccag
     4321 tgtgagaaag atatcaagtg tgcttgggat ttctgtagac aatggctacg gccactcgga
     4381 ggcagatgtc gctcaccagt cgcttctcga agcaaacatc gccactgagg tctgcctcac
     4441 agctctggac accctctcgc tgttcacact ggcttttaag aaccagctcc tagctgacca
     4501 tggacataat ccactcatga agaaagtttt tgatgtctac ctgtgtttcc tccaaaagca
     4561 tcagtcagaa atggctttaa aaaatgtctt cactgcctta aggtcattaa tttataagtt
     4621 cccctcaacg ttctacgagg ggcgggcaga catgtgcgca tctctgtgct atgaggttct
     4681 caagtgctgt aactccaagc tcagctccat ccgcaccgag gcctcccagc tgctctactt
     4741 cctgatgagg aacaacttcg actacacagg gaagaagtct tttgtccgga cacacttaca
     4801 ggtcatcatc tctgtcagcc agctgatcgc agacgtggtt ggcattggag gaaccagatt
     4861 ccagcagtcc ttgtctatca tcaacaactg tgccaatagc gaccggctca ttaagcacac
     4921 cagcttctcc tctgatgtga aggatttgac caagaggatc cgcacagtcc tgatggccac
     4981 agcccagatg aaggaacatg agaacgaccc agagatgctg gtggacctgc agtacagcct
     5041 ggccaagtcc tacgccagca cccctgagct caggaagaca tggctggaca gcatggcaag
     5101 gatccatgtt aaaaatgggg atctctcaga ggcagcaatg tgctatgtcc acgtgacagc
     5161 tttggtagcg gaatatctca cacggaaagg catgttcaga caggggtgca cagccttcag
     5221 ggtcatcaca ccaaacattg atgaagaggc ttccatgatg gaagatgtcg gcatgcagga
     5281 tgtccatttc aatgaggatg tgctgatgga gctgctggag cagtgcgcag atggactttg
     5341 gaaggcagag cgctacgagc tgattgctga catctataaa ctcatcatcc ccatctatga
     5401 aaagcggagg gactttgaga gactagccca cctgtatgac acgctgcacc gcgcatacag
     5461 caaagtgaca gaggtcatgc actcgggccg caggctcctg gggacctact tccgggtggc
     5521 cttcttcgga cagggattct tcgaagatga agacgggaag gaatacatct acaaagagcc
     5581 caaactcacg cctctgtcag agatttctca gagactcctt aaactttact cggataaatt
     5641 cggttctgaa aatgtcaaaa tgatacagga ttctggcaag gtcaacccga aggatctgga
     5701 ttccaagttt gcttacatcc aggtgaccca tgtgaccccg ttctttgatg aaaaggagtt
     5761 acaggagagg aaaacagagt ttgaacgatg tcacaacatc cggcgcttca tgttcgagat
     5821 gcccttcacc cagactggga agaggcaggg tggcgtggag gagcagtgta agcgacggac
     5881 catcctgaca gcaatacact gcttccccta tgtaaagaag cggatccctg tcatgtacca
     5941 gcaccacact gacctgaacc ccattgaggt ggccatcgat gaaatgagca agaaagtggc
     6001 cgagctccgc cagctgtgtt cctcagctga agtggacatg atcaaactgc agctcaaact
     6061 gcagggcagt gtgagcgtcc aggtcaatgc tggcccgcta gcatacgccc gagccttcct
     6121 cgatgacacc aacacaaaga gataccctga caataaggtg aagctgctga aggaagtttt
     6181 caggcaattc gtggaagctt gtggccaagc cttggcagtg aacgaacgtc tgattaaaga
     6241 ggaccagctg gagtaccagg aagagatgaa agccaactac agggagatgg ccaaggagct
     6301 ctccgacatc atgcgtgagc aaatttgccc cctggaggag aagacaagcg tgctaccaaa
     6361 ttccctgcac atcttcaacg ccatcagtgg gacaccaaca agcacagtgg ttcaagggtt
     6421 gaccagttca tcctcagttg tgtgacttta cctcatgaac cacacgtggg gacatgcttt
     6481 gtcatgtgca aactcaggac gactttcaga gctaatcact ggttttgcca agcacaggaa
     6541 gaagccatgg ggaatgggag agagaaagag cctggactgt gatatttaat agcagatttt
     6601 ataggagttg ggggaaggtg cacatatttt tttaaatatc actggcaatg tttagttttc
     6661 ctcatgtctt aacaggtgta tgtggatact cttgggctgc agttcaattt tattcttctt
     6721 acagtatagt attaaaataa atggtctaaa ggaaaagagg gaaagtatgc tgggacacct
     6781 gtagcaggtg tgctgggaca cctgtaccag ctgtgctggg acacctgtac cagctgtgct
     6841 gggacacctg tagcagatgc agcagcactg aacctgggaa tggggactaa gctggaaaaa
     6901 tcttgaaaat atttttctcc ctgtggcaca ttcaggttga gtacaagaac tatttttgtg
     6961 tctagttttg aagactgaag ggaattgact attgagattt tttactagtg aatgcggaga
     7021 cttagagcct ttatatccat gccttgtgtt gacaacatga gcacttccga agctgagtgt
     7081 gatgtgagcc taagcctagt cagcagcata gaaccaaagg cctgcactag cgaacacacc
     7141 tatgctaaaa cctaaaaccc catgtacata tgttctgtta atacggcctc ctcgctgagt
     7201 ccacgtactt actacatttc tacactttta atacatcagt gtccgtgtta agtttattat
     7261 tcgtgaccca tttgtgctgt tctcggtata tgcaaataca ttggacttca ctgtttattc
     7321 ttgtacataa gaagtgcaat atggagatgt atacagtctt tgctatgtta ggtttataaa
     7381 ctgtttttaa aaagaaattc atccttttgc caaaatggtg gagtatgtga ttggtaaacc
     7441 ctaaaccctg tggtgagtgg agggataatt taaagttttc accatgttat attttctttt
     7501 aagactttaa tttagtaatt ttatatttgg gaaaataaag gtttttaatt taactggaat
     7561 cactgccctg ctgtaattac atatcgtgta ccccaactgt attaaaaata acactgctga
     7621 ttttctggta ataaa
//
LOCUS       NM_001437956            2571 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus caspase 14 (Casp14), transcript variant 1, mRNA.
ACCESSION   NM_001437956
VERSION     NM_001437956.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Gkegkes,I.D., Aroni,K., Agrogiannis,G., Patsouris,E.S. and
            Konstantinidou,A.E.
  TITLE     Expression of caspase-14 and keratin-19 in the human epidermis and
            appendages during fetal skin development
  JOURNAL   Arch Dermatol Res 305 (5), 379-387 (2013)
   PUBMED   23377137
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Alibardi,L., Tschachler,E. and Eckhart,L.
  TITLE     Distribution of caspase-14 in epidermis and hair follicles is
            evolutionarily conserved among mammals
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 286 (2), 962-973 (2005)
   PUBMED   16142807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.27729.1,
                                           SRR26643295.27357.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000007.1  11577336-11577487
            153-219             JAXUCZ010000007.1  11580311-11580377
            220-369             JAXUCZ010000007.1  11580781-11580930
            370-556             JAXUCZ010000007.1  11581031-11581217
            557-673             JAXUCZ010000007.1  11582168-11582284
            674-777             JAXUCZ010000007.1  11582443-11582546
            778-2571            JAXUCZ010000007.1  11583067-11584860
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2571
                     /gene="Casp14"
                     /note="caspase 14"
                     /db_xref="GeneID:299587"
                     /db_xref="RGD:1311781"
     exon            1..152
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Casp14"
                     /note="upstream in-frame stop codon"
     exon            153..219
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..882
                     /gene="Casp14"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="caspase-14 isoform 1"
                     /protein_id="NP_001424885.1"
                     /db_xref="GeneID:299587"
                     /db_xref="RGD:1311781"
                     /translation="MDSETINPQPLQEERYDMSGARLALTLCVTKAREGSEVDMDALE
                     RMFQYLKFESTMKRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLMAHGEEGFLKGE
                     DGNMVRLEDLFEVLNNKNCKALREHRDPGEELPGDELAVIKKKNPPTIPTYTDMIHIY
                     STVEGFLSYRHDQKGSGFIQTLTDVFIHKKGSITELLEEITRLMANTEVMQEGKPRKV
                     NPEIQSTLRKKLYLQ"
     misc_feature    208..879
                     /gene="Casp14"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cl00042"
                     /db_xref="CDD:444667"
     misc_feature    208..879
                     /gene="Casp14"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cl00042"
                     /db_xref="CDD:444667"
     misc_feature    order(277..279,460..462,562..564,679..696,706..711)
                     /gene="Casp14"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(277..279,460..462,562..564,679..696,706..711)
                     /gene="Casp14"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(565..567,634..639,658..660,667..669,676..678,
                     748..750,772..774,790..792,829..831,844..849,853..855,
                     862..867)
                     /gene="Casp14"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(565..567,634..639,658..660,667..669,676..678,
                     748..750,772..774,790..792,829..831,844..849,853..855,
                     862..867)
                     /gene="Casp14"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(568..570,631..633)
                     /gene="Casp14"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(568..570,631..633)
                     /gene="Casp14"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     exon            220..369
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            370..556
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            557..673
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            674..777
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            778..2571
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagacagga tctcagaaga aacttctgag tctgtccttt ctcagagagc aacacgtggc
       61 tctaactcct cctgagtgac agcgctgcat catccatcaa cagcttggag tcagacaagc
      121 cagggcctga cccaaggaga aggagcgcac cgggcaagac aaaggtgctg gaagccagac
      181 atggactcag agacgattaa tccccagccc ttgcaggagg agagatacga tatgtcgggt
      241 gcccgcctgg ccctgacgct gtgtgtcacc aaagcccggg agggttctga ggtagatatg
      301 gatgccctag aacgcatgtt ccagtaccta aaatttgaaa gcaccatgaa gagggatcct
      361 actgctcagc aatttctgga tgatatggat gaatttcagc agaccataga gaattggaaa
      421 gagcctgtca gctgtgcctt cgtggtactc atggcacacg gcgaggaagg cttcctcaag
      481 ggagaagacg ggaatatggt cagactggaa gacctttttg aggtcttgaa caacaagaac
      541 tgcaaggccc tgagagagca cagagacccc ggtgaggaac tacctggaga tgaacttgct
      601 gtgatcaaga agaaaaaccc cccaactatc ccaacatata cggatatgat ccatatctac
      661 tccacggtag aggggttcct ctcctataga catgaccaga aaggctctgg cttcatccag
      721 accctgacgg atgtgttcat tcataaaaaa ggatccatca cagagctgtt agaagagatc
      781 acccgactta tggcaaacac agaggtgatg caggagggaa aaccaaggaa agtgaacccc
      841 gaaatccaaa gcaccctccg gaagaagctc tatctgcaat aaaaggaaag gcagtgacgg
      901 ccttcctgca gccgctttct cggtcgccac cagtcttcaa agatagttcc tggattcttc
      961 attcatcaca gcccttcatc tgtatcagtt tcagagcaag ccaggcaacc agagcacatt
     1021 gacgccacct tcctctgcct ggactccctg actctgttaa tgcagcctcg catggtcttc
     1081 ctatagctac ctttcggctc ttttgcctca ccaagccttc cttttcctcc aacgactcaa
     1141 ctgaaaatgg tcattcctat ttcagaggta gtagctttct gaacaatttc tagaaacttc
     1201 caataaccaa ttaaggtcac cactgtggaa tctgggcagt aggctggaag agagaccagc
     1261 catgttggct ttacggtcat tatgagtcac aacttaagac gggtctcttc tttctggtct
     1321 ctcttctcag gctttcccag cttcctcctt ttcttgttct ttgcctggga ttctttctat
     1381 agctcataca cccctcactt ccctccagct gactttgaaa tggctttcgc atccgtctct
     1441 cttctcttcc ccggaccctc aaggctcggc ctgaatgatc tcaactctgc cacagccaga
     1501 attcttcctc ctctctctgc ataacctgtg ggggaattct ctctgaaaca cgctgaaaga
     1561 tacaatgagc cccgagacca aagctaaacg acatcatatt cttgtttctc atgcttggtg
     1621 tacaattcat cattgtaagg aaatcagggc aggacataca acagctagtg acaataaata
     1681 ttcttactca aaatcaaagg actggagcat gaaacaatca caccaaaacc cccagaggac
     1741 ttgagtagcc cttcctgcag tccagctagt aactttctta ttccaaaagg tttaccccag
     1801 taaagaagat accatgataa tggtgctggc ctctggtgat ctcagcagct tcttcagccc
     1861 aagcatggtg aacacacaca aatccttagt caaattatct ataaatagtt ttatttgttc
     1921 ctgacagagt ctttgcttct ctccaaaacc ccacgagcta ggcctcaatg atcccaaaac
     1981 aacctatgag ttctgtttcc agaatttaat ggcttttcca gtccactata cctaaagctt
     2041 tcaaattcct cccacaaaac atgtccaaat cataaaagcc acatggtcag gtctatcaca
     2101 gcagtgaccc tacttccttg gtatcaattc ctacgaaaga ggtgtctctg gaagcctaga
     2161 ggagacacaa agagcactaa tatttagaga ccaaaggcaa gccctacatc tgtggttttt
     2221 gatgtggttt tttttatatt tttatgactc catccaatct gccctcagat aaattcatct
     2281 ccttttctat gaaattgttc tcccagaaat gctagcatcc tctctctctc ccctctgcct
     2341 ctgtgtcttt tgcccaatag accgattctc caagcttagg tctcccacat gcctgcctct
     2401 tctctttttc cctttttcca gtgcctcccc ctcaccactg actccactcc taatgttctt
     2461 tttagcttat gctgcggtct cttccatgat gaaatgctgt aattactttt gtcagatgtc
     2521 aacctttgat tggtgtaatg agaattcagt aaacatctgt tgaattttgc c
//
LOCUS       NM_001437935            8988 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 6, mRNA.
ACCESSION   NM_001437935 XM_006242391
VERSION     NM_001437935.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8988)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8988)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 8988)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 8988)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 8988)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 8988)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8988)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8988)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 8988)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 8988)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006242391.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2786621.1,
                                           SRR26360172.2730191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000007.1  136229085-136229132 c
            49-148              JAXUCZ010000007.1  136228828-136228927 c
            149-331             JAXUCZ010000007.1  136227163-136227345 c
            332-518             JAXUCZ010000007.1  136218085-136218271 c
            519-619             JAXUCZ010000007.1  136213218-136213318 c
            620-8988            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..8988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..8988
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..48
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            49..148
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            149..331
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    171..173
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             195..770
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424864.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    249..398
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    249..398
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(249..260,309..311,315..317,348..350,360..380)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(249..260,309..311,315..317,348..350,360..380)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    540..713
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    540..713
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(567..569,573..587,609..611,636..638,696..698,
                     705..710)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(567..569,573..587,609..611,636..638,696..698,
                     705..710)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(579..581,693..701,705..710)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(579..581,693..701,705..710)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(663..665,675..680,684..689,696..701)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(663..665,675..680,684..689,696..701)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            332..518
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..619
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            620..8988
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccctcc tgttagccca gagggaaaga acgaactggg gcgatccggg aaggccatag
       61 ccacaatgct taactgcatg cttccaacat ggggctggtt ttaacccagc gctctgacct
      121 aaagtgctca gctcccggaa attccaagga acctggtggc cgcactcctt taggtggacc
      181 aacacatacc caacatggga aagaagacca agaggacagc cgacagctct tcatcagagg
      241 atgaggagga gtatgtggtg gaaaaggtgt tggacaggcg catggttaaa gggcaagtgg
      301 agtatctgct gaagtggaaa ggcttttctg aggagcacaa cacttgggaa cctgagaaga
      361 acttggattg tcctgaacta atttctgagt ttatgaaaaa gtacaagaag atgaaggagg
      421 gagagaacaa caagcctagg gagaagtcag aaggaaacaa gaggaaatcc agtttttcca
      481 acagtgctga tgatattaaa tccaaaaaaa agagagagca aagcaatgat atcgctcggg
      541 gctttgagag aggactggaa ccagaaaaga tcattggggc gacagattcc tgtggagact
      601 taatgttctt aatgaaatgg aaagacacag atgaagctga cctggtcctt gcaaaagaag
      661 ctaatgtgaa atgtccacaa attgtgatag cattttatga agagagactg acgtggcatg
      721 cgtatccaga ggatgcggaa aacaaagaaa aagaaagcgc aaagagctaa aggaggaggc
      781 agtctctgtc atttctcttt gtatataata ccttcacctt cctgcctcct ctcgcttctc
      841 ccgtcccttt ccatcctaaa catatccata aaaatgatgt gcttatcaat cactgtgctc
      901 cacgggagag atgttggtat tggttccctt gtaatataac tgatggtctg actcctaagt
      961 gtagctctgt gaaagtcagg cattacatcc ttcacatgct gtgtggttcc catagtgttc
     1021 tctttcatcc tgatcttttc cttctgttcc ctgtaacttt taatcacctt agagtcgtga
     1081 tctttggggt tggttgcttt ggggaatttt attataatga cgatgacttc agtttcttgg
     1141 ttgttaatta gaatatattg atgaccagct ggcctttgtt ttgacatact ggcatagaaa
     1201 ggatgttgtc cagcttttag aaagctaata gcagcagcct acatgttgtg tattttttaa
     1261 tctcacttag ctctgccagg agaatacagg gtccctggtg tggtcttctg ggccactcct
     1321 gactattctc acctaccctc ccataacaac tcagttctct tgagggcttg agactttaca
     1381 ctgtttagcc ctcacactct tttggcttcg ttactttcaa tccctgattc tgcttctgta
     1441 aagtgtatca gtttgttatt aaatgacagg attaactgtg gggtctgtaa gctgtagtgc
     1501 aggacgataa caggacgggg ctggatgcgg ttgtctttgg tatcacatgg tgtgcatgtg
     1561 ttctttcctt caccctcatt cctagactct atttatgtag gtgtagggac tgcctggtgc
     1621 ttgcttgtgc caagcaccct gccaactttt atggcctccc aaagcattcc tgtaccaaag
     1681 aggaatcagc agatccacac attcccttcc gtgccgttat tttaagttgg gaattgttag
     1741 aaaggaacca ttagccacag tgtcatcagt ttctaaatcc tcacagcagt gatagatact
     1801 ctttaacttt accactaagt ccctagagga ttaatgttcc tgccctctcc atcctcagac
     1861 ttttagttgt agcttatttt aaaaactatt ttcatggaag accatcgcct cagaaaccaa
     1921 caggtcttga cattagcttt ttgacacaac cttctcccac aacaaactac tcctttttga
     1981 tttactctta ctttgctatt atttctgctc ctgttctgtt ctttttgtcc cctgaaaatg
     2041 tccatcttct cttcattcct ttcttcttat atagttgagg agactgagaa tcaggactaa
     2101 atgtaaggaa ataacagggt ttggagctga gcactctttt tttttttttt cccccccccc
     2161 cggagctggg gaccgaaccc agggccttgc gcttcctagg taagcgctct accactgagc
     2221 taaatcccca gccccaggag ctgagcactc ttgacccagc tcaaaagctg aggaaaagga
     2281 gtaaacgctg agatagcctt aattctagac tttatcaact actgaggctg tttttgttgt
     2341 tcctttcggt ttttaaagca tagctatctg agcagccacc catttctaga tcgttcatgg
     2401 taatgagggg aaggagtgga gtgctctggt ccacagatga cccaagtgtg tgcacgtcct
     2461 agacccattc agtgtttgct agcatcactt ctctgctcag ctgccactga gctctgtgtt
     2521 cttgaataaa ttatgtcaac aattatactg cacagttgac aggacagcca ggaagaacct
     2581 gtgaatggta ctgtggtagg ggaagagcac ctaaccctta cctctccgta gttcattctc
     2641 tgaagatggt agaggcaagc tcaaaggctg gataagtgac cattgtctgc ttaacttgat
     2701 gaaatgcagg tggttagaga gcagatgtgt ccttcacgca acctagacta gtaattaggg
     2761 cagatgaagg tagcccagaa gtggcccagt tcctgaggat cttagtctct gattagcagc
     2821 tggagggaag gacagcctgc tgagcactca gcagcagtgg gctgtaaact ggcagtggaa
     2881 ggactgagta tacagtttga ggatttaatg ccttgtaatg caaaaaatga agggaaggag
     2941 tggcctgctg gttttaatgc tctttacaat gtttttccct ctcaaaagtt catggagtat
     3001 tggttttctg ttaattatta ccaaaactct cttgtccgtg tctccccccc ccccccccca
     3061 gctggggacc gaacccaggg ccttgcgctt gctaggcaag tgctctacca ctgagctaaa
     3121 tccccaaccc cttgttttcc tcttagtaag tttcctggtt atatatagaa atagggaacc
     3181 gggattccag tattctcttc agctctcagt atgaagaagc cagacaccca tttgtgcctc
     3241 cagcctgtgt tgtgccaagt agcttgattc tgctggagaa ttgcagctgt ggacaaaagt
     3301 gtttcctaga gttatcttct atcttcgctc taaagagttc atggccaaag gtgaaagaaa
     3361 tactcctaaa cactgactat attctcctgt gttaaccctc tccagaacta attttgtggt
     3421 actggaaatt gaacctagga ccagcgtgga cagccgggca actgctgtgc catttttgtc
     3481 tgcccccttt cctcccctgc catacagttg atggatcacc aaattcacct gtttttgttg
     3541 ctctaaggac tttaagtcac tgataccaag ctaaccttgg ttgtataacc aagttgaatt
     3601 cttttttttt tttttttaaa cttatgtgac tatgttgttg ctgtcttcag acacaccaga
     3661 agaaggcatc ggatcacatt acagatggtt gtgagccacc atgtggttgc tgggatttga
     3721 actcaggacc tctggaagag cagtcagtgc tcttaaccac tgagccatcc tccagccctg
     3781 ctaagttgaa ttcttttttt ctttttttct ttttcttttt cttttttccg aagctgggga
     3841 ccgaacccag ggccttgcgc ttgctaggca agcgctctac cactgagcta aatccccaac
     3901 cccctaagtt gaattcttga tctcctgcct cttcccagtc tctaggatta taggtatgtg
     3961 ccaccatatc tggctcttag ctccttctat atggagttat ctgtgctagc caggtacagt
     4021 gtaatacacc tttatttcca gtctttagga ggcagaagta gataaatctt aatcggaggc
     4081 ctgcctggac tatatagtga gttctaggcc agccacacct acatagatct tgttgtgaaa
     4141 ggaaaaatag gaaaagagta cccagattgg ccttgaactt aggatcttta tgtatcagtt
     4201 gtatgccact atgcctggct caaaatgcct ttttttttct ttattaactt gagtatttct
     4261 tatttacatt tcgatttttt ttaagttata tatatatgtg atttctgcct gcatgtatat
     4321 gcaccatatg catgcctggt tccctaggag acagaagagg gtctcatatc ctcttagata
     4381 ggagtgagcc actatgtggg tgttgagaat cagatctgga agagtagtca gtgctcttaa
     4441 ctgctgagcc atctcccacc cttcaaaaca tctttctaaa gttgaatttc ttcccccccc
     4501 ccttttctgt ttagtcctga ctgtttcttg ctggcttcac cctctagtgc tcacgttttg
     4561 ctagctttgt gcaaaaacag gtgaactggg tgatccatcc tcaattttac acattgtgtt
     4621 gttcacattt ctacaacttt agcatacatc aatattgttt tcattcaaca aacagttttg
     4681 gctcaggaac tcgctagaga actttgatag tggtgtggga tgagttgatc agtatagttt
     4741 tggataatga atactgcaca tgtatataaa ttactggtct gggacagcat caggtataca
     4801 aaaaggtgag tctttagtgg gcagttagtt aagtggttga gtgctggtga ggaatccatg
     4861 aagccctggg tttccacggg ggggggggta aggtaaatct gcagtaggag gggggggtaa
     4921 ggtaaatctg cagtaggagg ggggggtaag gtaaatctgc agtaggaggg tgccattaac
     4981 tgcttcatct gtgggaaaga ctgtggtctt ggatgaactg agttaactgg ccatgggcag
     5041 cattgcagga aataaagcta gaaaggcttt cgtttcgtta ccaagagtgc agatgaatga
     5101 gcgtgagaac tgtcttgttt agactgccaa gcattcatga ctgtgttagt attgcctgtg
     5161 ctggtgtata tttcttcttt gtgggcgttt tagcaagttg ctcacactgt tcaatttctc
     5221 acccttttgg agaaatcaac attagtctgg ctttaaagcc caaaacatac catctaatga
     5281 caagacttcc ttagaacaaa gcttaggaat gagctacctt tggatcacgt gggtctcagt
     5341 gccagggagt aagcagctcc tgtgtcactt atatcaaaac cttccacagg aataatgtgc
     5401 tctggctcct cattgtgcgt gacacccttc tcagagaagg aaaggtctgt ttttcaggtt
     5461 cttattctga ctcctgagag cccaagacga agatgtaatt gactgacttt agaagtcaga
     5521 attcccagaa attcaactaa ctgctctaga aggttaaaat gtgaagtttc ttgtttgttt
     5581 tttgcttgtg ctgaatattt tgaattttca tctacctcgt cttatttttc ttagttactt
     5641 ctgtcattac cacttgagca tcaagcttga ttttggtcat tgtctaaaat ggggtctctc
     5701 ctgttcagtg acagtttatt cccttgtctt tcctcttggc cctcatttca cctaacatca
     5761 tctcttattg ctcctgtcag aaatatgttt taaagtcttg ttttatggga aaaagtggtc
     5821 caccaatgct gtttgtctct gaggtcagtg agagaaggag ttaaaacaca gtggtggagg
     5881 aagggcagag cctgcctgca ctggaggcaa aagctgacaa ggaaggagtc attaattaaa
     5941 gacaatttca aagtcaactg attgtgatca ttaatgtcac aatagatcaa aacctaatta
     6001 tcacagccta ggtaagagcc atcagtatta atcggaaaat ctaataggaa actattagca
     6061 agaaattagg ccaaattgaa tgcaatgaac tttttatcat ctttttttgg taatgttctt
     6121 ggtgttggca actgtgaccc taacagttgg tccaagccca gattgctaat tttaaagagc
     6181 cttttttttt ttttttttta agtaacccag gctgacccta gtgcttacag ccctccagct
     6241 tcagccttga gcactgggat tatgaggggt acatgcattt gtgtttgtgt gggtgggtag
     6301 gagagaattg aactcagggc cttgtacatt ttagacaagt gctctaccac tgaactgtat
     6361 tcctagctca gagtgttttg tttgttaggg aagtttccag acagactgaa cctaagctga
     6421 cattgctgaa acaccagcct tgaatttttt tatcatatgg atctattcat tctaatcaga
     6481 tcagcgggat ataaacatat atattaaagt cgtagagtgt ccctagtgaa catcatatca
     6541 tctgttgagt gcttgtatat agagttctat actggttgtt gtgaaggctg tgggaggaag
     6601 gcagtgtcct gctttgaaat tctttgaaaa ctaaaaagat agtttccttg tgtgacagca
     6661 tgatcaagat gcaagtctgt gtttttcagt ttccattagc attagggttt gatcctaaac
     6721 cagcttagca gtgcccccaa ccccaatagt tttaagatag gcacaaaatg atttcctact
     6781 ggaattctaa ggtatgggga agacatcttt gtttctgttt tcctttctgg tagtaggaga
     6841 agcatcagta tgtccttaag atgtttgtaa agatgctacc ccctttaggt gagatgagtc
     6901 aggctgtgga acggttgctg tcacaggagg agtgccaggc agtagtagag ggaattgtgc
     6961 ttaggagtct gcactgtgcc ctgcagccct cagatgctca gtgctgacct taggaggccc
     7021 atgctgcttt ctggaccttg ggaacctgga ttacccagta gaagactgag aatcaatgtc
     7081 ttttgtttgt ttgtttattt tttgttctgt ttttgttttg ttttgttttg ttttccaaga
     7141 tggggtctct gtgtagccat ggatgtcctg gaacttgctc tgttgaccag actggcctcg
     7201 aactcaaaga tctgcctgcc cctgcctccc aagtactgtg atcaaacgtg tgcgccatca
     7261 ctgcctggct aacccttcac ttcttagtga gttttagtgt ttaaaaaatg caacttaatt
     7321 ttcaaagtgg cactaaggtg gtttgtccag ccttgggtta ctccaggtga gcagcagccc
     7381 tcaattaaca gtgtgttgat tggactcatc cggctgcagt gaaatgactg aaagtgagat
     7441 gttctagtgc atagttctgt gctaacctcc tacttggtct taatggctga ccttgggcaa
     7501 gtctttcctt tcaatgcctc agttccccat ctgtcaaatg gggtgataat actgacctac
     7561 ctcatggggt gttgtgaggc attacagatc agagctgatc aaccctttag gattgcctgt
     7621 ggaggatacc ttaagtcgga ctcttttagc cctcactgag ctacttccaa gtttggaagt
     7681 agttagtgac cttggcgagt ttctgtcccc ccacccttta cccctcatca aagctgctag
     7741 ttcagatgtt aacagtgttt tgtgaatgtt ggagtcttga tcgtccagtc taacttggga
     7801 caatgtaagg gaaggcactt gtgggttctg tgtcttatat tacaaagaga ctgttagaaa
     7861 ttcaagagcc ttggtttagg aatcttgagg caggaatgct accgcatgtc tttctctgca
     7921 ggagttaagg tcctattctc atggacttat aactacttct gactgtcttc gaaaggaagt
     7981 gacacttggt attttggatt tatattgttg ctttcatttt ccagactgat cctaggacag
     8041 ttagtctact gaacccttca tgcttctatg cctctgccct ctcatagaag ccagatggtt
     8101 caagcaacat agctctccct tcccccacca aaaagctgta ttggattttt gtttttttgt
     8161 ttctagaaat aggtgtaaca tttcagaatt gagcattggt cctcaaggct tcttccagtt
     8221 cactgtgtgt ggaatctgtc acctcttttc agtgtccacc atctgaccca ctgaggacat
     8281 cttggacact tgtttgccca cttgagggtt caaaagcctt actctgtgtt tcagtatagg
     8341 gctaaggcat ccccaagctc ttcgtgatag gtttcctttc ccctacttga ccttgtattg
     8401 gtaccatgaa aaagcacaca gtcctagctc cctggaggta cacactccag tactgttagg
     8461 tggactctac tcctaacagg gatcctagag ggttctctgg aggatgggaa aggagcagtc
     8521 tcatgtcctg ccaagtagta gccagcagtt gccttacccc tgcctgctgg ccatgttccc
     8581 acctcctcat ggagagggct ttcagaggtc ctcgaggctg gattttctca gtctctgctg
     8641 tgccattctg agtgggaagc agaccacact ttgtggccag gtgtctaagt ggaagtgagg
     8701 tcttgaattc tcggtggact ttttggtttg tgggggagtt ttggttgtgt ttcttggttc
     8761 tatttcagcc aaactcgcct gcttttgatt tctttaaagg ataagtggtc tatctatcta
     8821 tatacatgta tgtttgcatt ttaagtgtaa atgttttgaa aaaaaaaaac agacatgtct
     8881 ttctataact gacatccgat tcagacatca ttctctcccc ttccaccctc ttttccctct
     8941 tttcatactc ttgtattggt tctaataaag gattgctttt caaatatg
//
LOCUS       NM_001437912            4032 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 6, mRNA.
ACCESSION   NM_001437912 XM_063282149
VERSION     NM_001437912.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4032)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 4032)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 4032)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 4032)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4032)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4032)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 4032)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063282149.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.3161.1,
                                           SRR26643295.9797.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000002.1  177791555-177791637 c
            84-213              JAXUCZ010000002.1  177786942-177787071 c
            214-291             JAXUCZ010000002.1  177784108-177784185 c
            292-402             JAXUCZ010000002.1  177782701-177782811 c
            403-571             JAXUCZ010000002.1  177779310-177779478 c
            572-667             JAXUCZ010000002.1  177778834-177778929 c
            668-713             JAXUCZ010000002.1  177775282-177775327 c
            714-826             JAXUCZ010000002.1  177774722-177774834 c
            827-886             JAXUCZ010000002.1  177771737-177771796 c
            887-939             JAXUCZ010000002.1  177768704-177768756 c
            940-1025            JAXUCZ010000002.1  177766872-177766957 c
            1026-1197           JAXUCZ010000002.1  177765163-177765334 c
            1198-1396           JAXUCZ010000002.1  177760418-177760616 c
            1397-1674           JAXUCZ010000002.1  177758391-177758668 c
            1675-1847           JAXUCZ010000002.1  177758048-177758220 c
            1848-2037           JAXUCZ010000002.1  177756072-177756261 c
            2038-2092           JAXUCZ010000002.1  177755325-177755379 c
            2093-2267           JAXUCZ010000002.1  177753749-177753923 c
            2268-2340           JAXUCZ010000002.1  177753274-177753346 c
            2341-2536           JAXUCZ010000002.1  177751968-177752163 c
            2537-2625           JAXUCZ010000002.1  177751792-177751880 c
            2626-2679           JAXUCZ010000002.1  177749533-177749586 c
            2680-2761           JAXUCZ010000002.1  177747255-177747336 c
            2762-2979           JAXUCZ010000002.1  177746302-177746519 c
            2980-3085           JAXUCZ010000002.1  177745433-177745538 c
            3086-3153           JAXUCZ010000002.1  177740434-177740501 c
            3154-3351           JAXUCZ010000002.1  177739078-177739275 c
            3352-4032           JAXUCZ010000002.1  177736374-177737054 c
FEATURES             Location/Qualifiers
     source          1..4032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4032
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..83
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..213
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             124..3390
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 6"
                     /protein_id="NP_001424841.1"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGT
                     KSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGSSS
                     GNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGAWRTATEEWGTEDWNEDLSET
                     KIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPSLAQPL
                     VFSNSKQNAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQAL
                     AQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFTPSSTM
                     MEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQ
                     KKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAP
                     SSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPS
                     SISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSESPSTSSIPSLNETVPA
                     ASLLTTASQHSSSLSGLSHSEEIPNTTTTQHSSALSTQQNTLSSSTSSGRTSTSTLLH
                     TSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRS
                     SVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYS
                     IPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQ
                     QTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASAT
                     PFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLP
                     SALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQDILTLVDDQLGE
                     "
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1669..1752
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1669..1752
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            214..291
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..402
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..571
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..713
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..826
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..886
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..939
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1025
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1197
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1396
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1674
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1847
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2037
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2092
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2267
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2340
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2536
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2625
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2679
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2761
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2979
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3085
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3153
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3351
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..4032
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgaggt aaagttggca gcgcagcggc gttggcggcg gcggcggcgg
       61 cagcggcaac gcggcggggc cggtattctt ccttgtaaat actgttattt gtatatactg
      121 taaatgatga cgtcggtggg cactaaccga gcccggggaa actgggaaca acctcaaaac
      181 caaaaccaga cacagcacaa gcagcggcca caggccactg cagagcaaat tcgacttgca
      241 cagatgattt cggaccataa tgatgctgac tttgaggaga aggtgaaaca attgattgat
      301 atcacaggca aaaaccagga tgaatgtgtg attgctttgc atgactgcaa tggagatgtc
      361 aacagagcca tcaatgttct cctggaagga aatccagaca cgcattcctg ggagatggtc
      421 gggaagaaga aaggagtctc aggacagaag gatggtggac aaactgaatc taatgaagaa
      481 ggaaaagaaa atcgagaccg ggacagagac tatagtcgac gacgtggtgg gccaccaaga
      541 cgggggagag gtgccagccg tggacgagag tttcggggcc aggaaaatgg attggatggc
      601 actaagagtg gtggaccttc tggaagaggc acagacagag ggagaagagg ccgtggccgg
      661 ggcagaggta gttctggtag acgaggagga aggttttctg ctcaaggaat gggaaccttt
      721 aaccctgctg attatgcaga gccagccaac actgatgata actatggcag tagcagtggc
      781 aatacatgga acaacactgg ccactttgaa ccagatgatg gaacaagact tgatttcatt
      841 ggggttgagg ggtcaaatta tccccgaaaa tttgagactg ctcctggtgc atggaggact
      901 gcaacagaag agtggggaac tgaagattgg aatgaagatc tttctgagac caagatcttt
      961 actgcctcta atgtgtcttc agtgcctctg cctgcggaga atgtgacaat cactgctggt
     1021 cagagaattg atcttgctgt tctgttgggg aagacaccgt cttcaatgga gaatgattca
     1081 tctaatctgg atccatctca ggctccttcc ctggcccagc ctctggtatt cagtaattcg
     1141 aagcagaatg ccatatcaca gcctgcttca gggaatacat tttctcatca tagcatggtg
     1201 agcatgttgg ggaaaggatt tggtgatgtt ggggaagcta aaggtggcag tacaacaggc
     1261 tctcagttct tggagcaatt caagactgca caggccctgg ctcaactggc agctcaacat
     1321 tctcagtctg gaagcaccac cacctcctct tgggatatgg gctcaacaac acaatcacca
     1381 tcactggtgc agtatgattt gaagagtgca aatgattcaa cagtgcacag tccttttaca
     1441 aagcgccagg cattcacccc atcatcaacc atgatggagg tgttccttca ggagaagcca
     1501 cctgcagtgg ctacctcgac agctgcacct cctcccccct cttctcctct gccaagcaaa
     1561 tccacctcgg ctccacagat gtctccgggg tcttcggaca accaatcctc cagccctcag
     1621 ccggctcaac agaaactgaa acagcaaaag aagaaaacct ccttgacgtc taagattcct
     1681 gctctggctg tggagatgcc tggctcagca gatatctcag ggctaaatct gcagtttggg
     1741 gcattgcaat ttgggtcaga gcctgtcctt tctgattatg agtccacccc caccacgagc
     1801 gcctcttcaa gccaggctcc cagtagcctg tataccagca cggccagtga gtcttcatct
     1861 acagtttcat ctaatcagag tcaggagtct ggttatcaga gtggcccaat tcagtcgaca
     1921 acttatacct cccaaaataa tgctcagggc cctctatatg aacagagatc cacacagaca
     1981 cggcggtatc ccagctccat ctcttcatca ccccaaaagg acctgactca ggctaagaat
     2041 ggtttcagct ctgtgcaggc cacgcagtta cagaccacgc aatctgttga aggtgctaca
     2101 ggctctgcag tgaaatctga atcaccttcc acttctagta taccctctct caatgaaaca
     2161 gtacctgcag cttccttact gacgacagcc agtcagcatt catcctcctt aagtggcttg
     2221 agccatagtg aggagattcc aaataccacc accacacaac atagcagtgc attatctaca
     2281 cagcagaata ccctttcttc atcaacatct tctgggcgta cttcaacatc tactcttttg
     2341 catacaagtg tggagagtga agcgaatctg cattcttcct ccagcacttt ctctaccacg
     2401 tccagcactg tctctgcacc tcccccagtg gtcagtgtct cctccagtct gaatagtggc
     2461 agtagcctgg gccttagcct gggcagcaac tctactgtca cagcctcaac tcgaagctca
     2521 gttgctacaa cttcaggaaa agctcctccc aaccttcctc ctggagtccc gccattgttg
     2581 cctaatccat atattatggc tccagggctg ttacatgcct acccgccaca agtatatggt
     2641 tatgatgatt tacagatgct ccagacaaga tttccattgg attactacag tatcccgttt
     2701 cccacaccca ccactccact tactgggagg gatggtagcc tggccagcaa cccttactct
     2761 ggcgacctca ccaagttcgg ccgcggggat gcctcctccc cagccccagc cacaaccttg
     2821 gcccaacccc aacagaacca gacgcagact caccacacca cgcagcagac attcctgaac
     2881 ccggcgctgc ctcctggcta tagttacacc agcctgccat actacacagg ggtcccgggc
     2941 ctccccagca ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag
     3001 cagcatggtg tgaatgtcag tgtgaatgcc tcggccaccc ctttccaaca accaagtgga
     3061 tatgggtctc atggatacaa cactggtgtg tcagtcacct ccagtaacac gggcgtgcca
     3121 gatatctcgg gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat
     3181 tccggtactc ctgctgcctc cttcaacttg ccttcagccc taggaagtgg agggcccatc
     3241 aatccagcca cagctgctgc ctacccacct gcccccttta tgcacattct gaccccacat
     3301 cagcagccac actctcagat ccttcaccat cacctgcagc aggatggcca ggatatcctc
     3361 actctcgtcg atgaccagct tggtgaataa gtattaccgt accaactggg cctcttctag
     3421 caggctcgaa ggctgtggaa taaagtgaaa tctttgccct ttaagaactc tcaccttaat
     3481 gtgctaatat tttgccctta aggggattcc cttttacatc ctgtgactga aaagaaccac
     3541 tgcacatctt catttcttct agaaactgcc tcacctacag caagtttcag gaagtgaaag
     3601 gggaaggagc taaggacatt taaaaggaaa aggaccttgt gggaatctaa gcatgattta
     3661 aaggattctg aaatctgaag ccagcattat ctactgtctg gcagaaccaa attgtagggc
     3721 ttttttcttt ttggaggagt atagtagttc ttgtctgagt tatgtttttg agacaatctc
     3781 actatgtaac cctgactggc tagaagttgt aacccaactg gctggaagtt ggtgtggaga
     3841 ccaggctggt ctcaaattca gagatctacc tgcctctacc tcttgagtgc caaggttaaa
     3901 ggttctcagc actatacctt accttgcctt ttttatgtga ctttgaaatg cctaagtttt
     3961 gggaaaggag tggatgatgg tagagcaaga cctggggtgg ggacatggtg cagtaaaagg
     4021 ttttggacat gg
//
LOCUS       NM_001437962            3612 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus midnolin (Midn), transcript variant 2, mRNA.
ACCESSION   NM_001437962 XM_017594815
VERSION     NM_001437962.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3612)
  AUTHORS   Obara,Y. and Ishii,K.
  TITLE     Transcriptome Analysis Reveals That Midnolin Regulates mRNA
            Expression Levels of Multiple Parkinson's Disease Causative Genes
  JOURNAL   Biol Pharm Bull 41 (1), 20-23 (2018)
   PUBMED   29311479
  REMARK    GeneRIF: These findings indicate that MIDN regulates the expression
            of a wide variety of genes, including multiple Parkinson's Disease
            causative genes and is associated with Parkinson's Disease onset.
REFERENCE   2  (bases 1 to 3612)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3612)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   4  (bases 1 to 3612)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_017594815.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38089.1,
                                           SRR26643295.27268.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000007.1  10208716-10208794   c
            80-710              JAXUCZ010000007.1  10206769-10207399   c
            711-798             JAXUCZ010000007.1  10205648-10205735   c
            799-861             JAXUCZ010000007.1  10205404-10205466   c
            862-1179            JAXUCZ010000007.1  10202930-10203247   c
            1180-1318           JAXUCZ010000007.1  10202592-10202730   c
            1319-1582           JAXUCZ010000007.1  10201724-10201987   c
            1583-3612           JAXUCZ010000007.1  10198761-10200790   c
FEATURES             Location/Qualifiers
     source          1..3612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3612
                     /gene="Midn"
                     /note="midnolin"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
     exon            1..79
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            80..710
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    328..330
                     /gene="Midn"
                     /note="upstream in-frame stop codon"
     CDS             475..1860
                     /gene="Midn"
                     /note="isoform 2 is encoded by transcript variant 2;
                     midbrain nucleolar protein"
                     /codon_start=1
                     /product="midnolin isoform 2"
                     /protein_id="NP_001424891.1"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
                     /translation="MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRY
                     DLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPT
                     VEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQ
                     HAPLQHRHVLAAAAAAAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSP
                     VTAGTFQSHAASTTCPETDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGVF
                     SGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCSP
                     ASPAPDLTPKTTSCEKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLL
                     QQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPEV
                     NPDIQSEFVVA"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     exon            711..798
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            799..861
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1179
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1318
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1582
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..3612
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccggcac ggccacctct caccacgacc catacgcagg tcgtctggag cagtggtgac
       61 acaggaccta cggcacccga tcttgagagc agcggctgcg gctgttgcta agggaaggga
      121 cgcgcggggt agcacgaccc gagagggatc caggcaccgt gcgaaccagg atagctcgcc
      181 ccgtttctgt tggaccctcc ccgtgccgta ccctggtcgc tgtcaaacgc cctagaaacc
      241 ggatcgcaga ccccaccccg gggcgcaacc caaggatccc acgcgacccc gagcaccatt
      301 cggattcttg attgccggct ctattgctaa cgttgggacc ttccccaagg ggcgcacgca
      361 ctgctcttgt ccctgggcgc ccacggagca gaggaggacc ttgttttggc gggggagtcc
      421 cggcaaggat tggaggcgac ccgcaggccc ccagttatcc tgcgcgcgcc ggggatggag
      481 ccgcagcccg gcggcgcccg gagctgccgg cgcggggccc ccggtggcgc ctgcgagctg
      541 agcacgaccg cggaatcggc cgcacccatg agcctggcga tccacagcac tacggggacc
      601 cgctacgacc tttcggtgcc ccacgacgag accgtggagg ggctgcgcaa aaggctgtcc
      661 caacgcctca aagtacccaa ggaacgcctg gcgctgcttc acaaagacac ccggctcagt
      721 tcggggaagc tgcaggaatt cggcgtgggg gatgggagca agttgacgct cgtgcccacg
      781 gtggaagctg gcctcatgtc ccaggcctcg aggccggagc agtccgttat gcaagccctg
      841 gaaagtttga ctgagaccca ggtcagtgac tttttgtcag gccgatcgcc tttgaccctg
      901 gccctgcgag ttggggatca catgatgttt gtacaattgc aactggcagc ccaacacgcc
      961 ccactccagc accgccatgt gctggccgcg gctgccgcag ctgctgccgc tgcccgggga
     1021 gattccagca tagctacccc agtatcctca ccttgtcggc ccgtgtccag tgccgcccgt
     1081 gtccccccag tatccagcag cccttcttcg cctgtgtccc cctcacctgt caccgctggc
     1141 accttccaat cccatgcagc ctccacgact tgtcctgaga cggactgttc tccacccgcc
     1201 agcagcaaca ccacatccac cccaggcagc agccccaccc cccgatcccg caaacccggt
     1261 gcagtcattg agagcttcgt gaaccacgct ccaggggtct tctcagggac cttctctggc
     1321 acactgcacc ccaactgcca ggatagtagt gggcggcctc ggcgtgacat cggcaccatt
     1381 ctgcagatac tcaatgacct cctaagtgcc acaaggcatt accagggcat gccggcctca
     1441 ctgacccagc tccgctgcca cgcgcagtgc tcacctgcct caccagcccc tgacctcacc
     1501 cccaaaacta cctcctgtga aaagctggca accccatcac tgctccaggg ccagagccag
     1561 atccgaatgt gcaagccccc tggagaccgt ctgcgacaga cagagaaccg tgccacacgc
     1621 tgcaaagtgg aacgcctcca gctcctgctg cagcagaagc gcctgcgaag gaaggcacgg
     1681 cgggacgccc ggggtcctta ccactggacc ccaagccgca aagctggtcg tagtgacagc
     1741 agcagcagtg ggggtggagg tagccccagc gaggccacag gcttgggcct cgacttcgag
     1801 gactccgttt ggaagcctga agtcaaccca gacatccagt ccgagtttgt ggtggcttaa
     1861 agaatcccct tgggcctgaa catcctctac cccatacacg gggcaggagg acgacacaga
     1921 ctggacgctg agcggcccag ctctgggggg gaggggcagg aggtcacctc cattgccact
     1981 taccagcctt tctgattctt ttttagctcc tcccctggtt gtctaccctg catccctggt
     2041 cacgtgccca cctgtctttc ttcccttacc atggtcaggg cctctgagac agggcccttc
     2101 cctcccacct tctccagttc caaatatgta gcagtctgtt cccagatggc ccagacggag
     2161 gaagccaccc accccagccc ttccgctctg cctagctctc cccaccccct tccataaccc
     2221 aattcaggtt tttaaactca atgtagattc tccaagcact ttacagatga gggttgggga
     2281 ccccaggatg agtgcgcccc cctccccttc ccctctgcag acttggccac cattccaggc
     2341 cagctggctc ccccacccct cccatcccgg aaagctacta gatacactca cagaggatac
     2401 ctttgtccac aatgcccact taactcacag ccttcctcct gcctcggtct cccaagtgct
     2461 acaatgacag gctttgccac tatgcctggc cgcccttgct cttgccacaa gctaattcga
     2521 tggagactgc tggagcaggg gggctgtttg ttagtcaggt gggggatgct ccttttcctc
     2581 atgagaggag gctaggcctc gcaccaccct ccctggacac tggcctcttg gtctcctccc
     2641 tccacacacc cacttatttc cctaaccttc cttcccaatg gggcttgagg gactatttat
     2701 agacttcatt tttctgactg agccagtaat ggtttctatc ctctagggga aagaaaagaa
     2761 actggggtag cttgtaggag gaggggccca gagagacacc cctgtacctc ttctctagtc
     2821 ccagcctgca gctggggatg ggaagagagg tgctgagctg tgactgcatt aaccccaccc
     2881 tggggagggc gggcgcactg ctgatccaca ttggctccat ggatgagagc cctcccctcg
     2941 gattggggcc catacagcag gggtgatctt gtggggtttt tttcctccac attttgagat
     3001 ttttgtgata aatgggatgt gtgcccaccc ctgatgcctg tccacgttgt ctagactcca
     3061 cctgtccacg gttcctttga tctaggctgt gaacccatcc ttgtcttccc ccactgtgtg
     3121 tttaaaccgt taatggtttg ggatgtgaac gtgtgttgac tagctgtaaa ggtttttggg
     3181 gtgggtgggt gggaaaggga tcctgaatgg tagaggccaa gtgagaattc ggtttggttt
     3241 tttgttttgt tttttttttt ctattttttt tcccaaaaag aaaagggagg ggggaaagtg
     3301 ggtgcatttt ttaagctgtc ttgaaatacc tatttaaatg tgtgttttgg tttttttagg
     3361 attttttttt aagctgcctg tgatatgtcc gctgggctga gggtggagac ctcaggcagg
     3421 agcccaccca tagttctctc ttccctgtga agacatcccc agatagcatt agccaccctc
     3481 ggggggaggg ggagaatccg gctatgggga atccacctcg cccaagtctc cttttattga
     3541 aataaaattt gaggggaaaa gaaaaacctt acacgagcac cgaatttcaa ataaatgaaa
     3601 acgagacatg aa
//
LOCUS       NM_199501               2233 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus cyclin dependent kinase 2 (Cdk2), transcript
            variant 1, mRNA.
ACCESSION   NM_199501 XM_343145
VERSION     NM_199501.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Matveevsky,S., Chassovnikarova,T., Grishaeva,T., Atsaeva,M.,
            Malygin,V., Bakloushinskaya,I. and Kolomiets,O.
  TITLE     Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero-
            and Homomorphic Sex Chromosomes
  JOURNAL   Int J Mol Sci 22 (4), 1969 (2021)
   PUBMED   33671248
  REMARK    GeneRIF: Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for
            Hetero- and Homomorphic Sex Chromosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Peng,T., Peng,J.J., Miao,G.Y., Tan,Z.Q., Liu,B. and Zhou,E.
  TITLE     miR-125/CDK2 axis in cochlear progenitor cell proliferation
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300064
  REMARK    GeneRIF: miR125/CDK2 axis in cochlear progenitor cell
            proliferation.
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Ren,S., Xing,Y., Wang,C., Jiang,F., Liu,G., Li,Z., Jiang,T., Zhu,Y.
            and Piao,D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Lin,Z., Liu,Z., Wang,X., Qiu,C. and Zheng,S.
  TITLE     MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal
            Tubular Epithelial Cells during Sepsis Associated Acute Kidney
            Injury via AKT/CDK2-FOXO1 Pathway
  JOURNAL   Biomed Res Int 2019, 2821731 (2019)
   PUBMED   31223614
  REMARK    GeneRIF: MiR-21-3p mediates metabolism and cell fate alterations of
            tubular epithelial cells (TECs) via manipulating AKT/CDK2-FOXO1
            pathway, and that is crucial in the regulation of energy metabolism
            of TECs during Sepsis and associated acute kidney injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Kotani,S., Endo,T., Kitagawa,M., Higashi,H. and Onaya,T.
  TITLE     A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly
            transformed rat thyroid (FRTL-Tc) cell line
  JOURNAL   Oncogene 10 (4), 663-669 (1995)
   PUBMED   7862443
REFERENCE   9  (bases 1 to 2233)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   10 (bases 1 to 2233)
  AUTHORS   Tsai,L.H., Harlow,E. and Meyerson,M.
  TITLE     Isolation of the human cdk2 gene that encodes the cyclin A- and
            adenovirus E1A-associated p33 kinase
  JOURNAL   Nature 353 (6340), 174-177 (1991)
   PUBMED   1653904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_199501.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061832.1, SRR26360176.1411493.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000007.1  1721613-1721917     c
            306-383             JAXUCZ010000007.1  1720839-1720916     c
            384-504             JAXUCZ010000007.1  1720620-1720740     c
            505-675             JAXUCZ010000007.1  1719299-1719469     c
            676-777             JAXUCZ010000007.1  1717972-1718073     c
            778-981             JAXUCZ010000007.1  1715897-1716100     c
            982-2233            JAXUCZ010000007.1  1714392-1715643     c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2233
                     /gene="Cdk2"
                     /note="cyclin dependent kinase 2"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
     exon            1..305
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    181..183
                     /gene="Cdk2"
                     /note="upstream in-frame stop codon"
     CDS             190..1086
                     /gene="Cdk2"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 2; cyclin dependent kinase
                     2-alpha"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2 isoform 1"
                     /protein_id="NP_955795.1"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
                     /translation="MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGV
                     PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP
                     LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYT
                     HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT
                     LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS
                     AKAALAHPFFQDVTKPVPHLRL"
     misc_feature    190..192
                     /gene="Cdk2"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); acetylation site"
     misc_feature    196..1047
                     /gene="Cdk2"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase 2 and 3; Region:
                     STKc_CDK2_3; cd07860"
                     /db_xref="CDD:270844"
     misc_feature    196..1047
                     /gene="Cdk2"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase 2 and 3; Region:
                     STKc_CDK2_3; cd07860"
                     /db_xref="CDD:270844"
     misc_feature    205..207
                     /gene="Cdk2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); acetylation site"
     misc_feature    214..216
                     /gene="Cdk2"
                     /note="CDK7 binding.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); other site"
     misc_feature    order(217..228,241..243,280..282,286..288,337..339,
                     379..381,427..438,445..447,451..456,568..570,574..576,
                     580..585,589..591,622..624,631..633,667..669,673..684,
                     688..690,802..807)
                     /gene="Cdk2"
                     /note="active site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,337..339,
                     379..381,427..438,445..447,451..456,568..570,574..576,
                     580..585,589..591,622..624,631..633,667..669,673..684,
                     688..690,802..807)
                     /gene="Cdk2"
                     /note="active site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,379..381,
                     427..438,445..447,454..456,580..585,589..591,622..624)
                     /gene="Cdk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,379..381,
                     427..438,445..447,454..456,580..585,589..591,622..624)
                     /gene="Cdk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    229..231
                     /gene="Cdk2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); phosphorylation site"
     misc_feature    232..234
                     /gene="Cdk2"
                     /note="Phosphotyrosine, by WEE1.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); phosphorylation site"
     misc_feature    244..246
                     /gene="Cdk2"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); phosphorylation site"
     misc_feature    order(298..300,310..321,325..327,334..339,343..348,
                     355..360,400..408,535..537,544..555,637..645,649..654,
                     658..669,1003..1005,1015..1023)
                     /gene="Cdk2"
                     /note="CDK/cyclin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270844"
     misc_feature    order(298..300,310..321,325..327,334..339,343..348,
                     355..360,400..408,535..537,544..555,637..645,649..654,
                     658..669,1003..1005,1015..1023)
                     /gene="Cdk2"
                     /note="CDK/cyclin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270844"
     misc_feature    order(337..339,451..453,568..570,574..576,631..633,
                     667..669,673..684,688..690,802..807)
                     /gene="Cdk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    order(337..339,451..453,568..570,574..576,631..633,
                     667..669,673..684,688..690,802..807)
                     /gene="Cdk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    451..456
                     /gene="Cdk2"
                     /note="CDK7 binding.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); other site"
     misc_feature    619..690
                     /gene="Cdk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270844"
     misc_feature    619..690
                     /gene="Cdk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270844"
     misc_feature    667..669
                     /gene="Cdk2"
                     /note="Phosphothreonine, by CAK and CCRK.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); phosphorylation site"
     misc_feature    685..687
                     /gene="Cdk2"
                     /note="CDK7 binding.
                     /evidence=ECO:0000250|UniProtKB:P24941; propagated from
                     UniProtKB/Swiss-Prot (Q63699.1); other site"
     exon            306..383
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..504
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..675
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..777
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..981
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..2233
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggaggcg gcaacattgt ttcaagttgg acaaattgtc aagagctgag ctctgcttgc
       61 gttccatccc gagctagggc tgccgtgctc acccgggccc ccaggtcctc cgctccgagt
      121 gtccggcccg ctttcgtcag ggttcccggg ccccgctccc gggggcctga gccgcctcac
      181 tagcgctcca tggagaactt ccaaaaggtg gagaagattg gagagggcac gtacggagtg
      241 gtgtacaaag ccaaaaacaa gttgacggga gaagttgtgg cgcttaagaa aatccggctc
      301 gacactgaga ctgaaggtgt gcccagtact gccatccgag agatctccct ccttaaggag
      361 ctcaatcacc ctaacatcgt caagctgctg gatgtcatcc acacagaaaa taagctttat
      421 ctggtgtttg aattcctgca ccaggacctc aagaagttta tggatgcttc tgctctcact
      481 ggcattcctc ttcccctcat caagagctat ctgttccagc tgctccaggg cctagcattc
      541 tgccattctc accgtgtcct gcaccgagac cttaagcccc agaacctgct tatcaacgca
      601 gaggggtcca tcaagctggc tgactttgga ctagcaagag cctttggagt ccctgtccgt
      661 acttacactc atgaggtggt gaccctctgg taccgagcac cggagattct tctgggctgc
      721 aagtactact ccacagccgt ggacatctgg agcctgggct gcatctttgc cgaaatggtg
      781 acccgcaggg ccctattccc tggagactct gagattgacc aactcttccg gatctttcgg
      841 actctgggga ccccagatga ggtggtttgg ccaggagtta cttctatgcc tgattataag
      901 ccaagtttcc ccaagtgggc tcggcaggat tttagcaagg ttgtgcctcc cctggatgaa
      961 gacggacgga gcttgttatc tcaaatgctg cactatgacc ccaacaagcg gatttcagcc
     1021 aaagcagccc tggctcaccc tttcttccag gatgtgacta aaccagtgcc ccaccttcga
     1081 ctctgatgtc cttcccaaag ccctcttcac ctgtggtctg acctgatcct gggccttttg
     1141 gacacaggtc agccttctgc tgttttctgg ctgtcttagc cttttctctg ggccagccgg
     1201 ttctggggat tcagaggtgc agagaaggat taggtgaaaa gggagaaagt tttggcatta
     1261 gatgcactta acccgacttc cagcttctct ccctcttccc agtcatcact gagaaggatt
     1321 agtattgaag caaaactgac agttctcccc agtgtcagat tttgccatcc caaccttaag
     1381 actgtctcat agttaccgtg ttgagggaaa tgcccccaga ctcctgctga caatgttttc
     1441 taaactaatg agcagaagcc taagttggga cagttcagaa ccaagcaaga ggggtccatt
     1501 ttaatgaatt agagtaaaaa aatagaccta agccatttgt accttagtct tagtgtttgg
     1561 cctcatctag caaccaagga agcctggttg gagaaacaga agaaatgatt ccctccagag
     1621 ccctgtctcc cttccccagg caagaagagc caggagggca caggcttacg cttcactctg
     1681 atctgtgtgc ttcacagggc aaggtgaaag acacttgaat ttcccttttt agcaatctta
     1741 ctgttttctg gtgctgccgg ctgaacccag gaccttgccc tcactaagca aatgtaccta
     1801 ccaccagtga gccagatttc gttcgagccc tcctttggga agttcagttc ttcagttgtc
     1861 agagagcctt attaccatct tcctctgaga gccaccctca ctcctagtag tggaagcgag
     1921 ctaggagaca tttcgagaat gctgatactt tttaaaggct gggttaggtc attgggggaa
     1981 attttctata aaagagtgaa caattatatt tatattttca agttagaata gtttggatat
     2041 ttcaatggtt ttttgtttgt tgtttctttt tttctttttt gtcagtgtgg atggatttgt
     2101 taccatgtgc actttgggat ttttttttta attgtttaaa gaaaatattt cttttatgat
     2161 ttccttctcc caccccgtgt tgttaatatt atttgtaatt tagtttgtaa ttcattaaaa
     2221 gaaaatattc tca
//
LOCUS       NM_001437981            2319 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            6, mRNA.
ACCESSION   NM_001437981 XM_063263523
VERSION     NM_001437981.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263523.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.939020.1,
                                           SRR26643293.41276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-75               JAXUCZ010000007.1  97509567-97509596
            76-255              JAXUCZ010000007.1  97509948-97510127
            256-553             JAXUCZ010000007.1  97510569-97510866
            554-740             JAXUCZ010000007.1  97512128-97512314
            741-915             JAXUCZ010000007.1  97512838-97513012
            916-1021            JAXUCZ010000007.1  97515701-97515806
            1022-1069           JAXUCZ010000007.1  97516474-97516521
            1070-1245           JAXUCZ010000007.1  97517084-97517259
            1246-1387           JAXUCZ010000007.1  97517640-97517781
            1388-1461           JAXUCZ010000007.1  97518224-97518297
            1462-2319           JAXUCZ010000007.1  97518931-97519788
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2319
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..75
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            76..255
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            256..553
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1752
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 1 is encoded by transcript variant 6;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 1"
                     /protein_id="NP_001424910.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELVASILEHNCNQTEETT
                     SPLPTGVLCALKSEDEVLILNLVQGCGLELEKSGCQLPWDPTVVPQLSALYACLTGLQ
                     LLTDPSPGLSRTVPEEETLICP"
     misc_feature    343..1047
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    343..1047
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    1105..1617
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    1105..1617
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            554..740
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            741..915
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1021
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1069
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1245
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1387
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1461
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2319
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgaggtccc aggagggcga
       61 tgcttgagga cccagcccaa ggctcatcct aaaatcaacg ccctgcacag acaggtgaat
      121 cccagagccc acctcaggga ggtcctggct tcaatgtcaa gaaaaccatg atacaacgca
      181 actggagata agaggaaact ggagtccacc ttaggtcctt ccgcacagga atttgtacaa
      241 ccacagggaa agcaaatcag gccagcttgc agctatcacg aagggatccc atatccagcc
      301 cgggatgata ttgtcccttg cctctcaagg agcatgtcat ctctgttctt gaggagcacc
      361 aaaagcctgg tgagagagct gggcaggaag ggtgagctgg tgccggtaga cagcctgaac
      421 agttcacagc gcctgcgccc cttctgcctg gtgaggaaga agcacaagca ttccctctgg
      481 ccttgggaca cacccctcat ccccacagac ttctccctgc tggatgtgct ggagcctggc
      541 tgccctgacc cagaggtgaa ccacagcaag cccatctatt cctgggagaa ggaggcagag
      601 ggattgacag gagctgtgag cgtgagtgct gggctgcaga gccaggtgac tggaagcggc
      661 acgaccacct gcctctctgc cttggcggtg cagacactct gggtctcccc gtttacctgg
      721 gagatgcttc ttgagaaaag gaaactgagg tcgcctaggc cctcgttcct ccaggaacta
      781 cagagccgga aggagaggga gagcctatat gtggtgaccg aggctgtgga gaccctgcaa
      841 gataccatac ttcagagcca cgaccaaatg cgaggagccg gacagctgtc cctcctacag
      901 ctgggccatg ttcaggtcca gggacagagc catgtggaca cagagaagat ggtgagcatc
      961 ccacagggca gtgttctggc ctacagggtt ctgcagctag tggtggaaga agatggctgg
     1021 gctgtccttt acttccctga aagaaagctc tgcaggaatg ccagagtagc tatagccttc
     1081 agccaggaat caggagaaga gtctaacttc tacagcttgc gggaccaagc agatagccag
     1141 ttgcaggacc tggtcacatt atcctcagag cgacgggcca cattgcttgg tgccctccag
     1201 gagctactac gggatcagca ggcactccag gagctagagg atacgctgga acaggctctg
     1261 gacacagggc tgctggcaca gctggagggc cctggaggct gtgtcttatg catcctccaa
     1321 gactctacaa gcaacttgtc atgctcgaaa ggcagggcta tcctctatat tcttggagcc
     1381 ttagcagcac tgagtgaacc ccagcattgc ctgctggccc agtccataga gagacaaatc
     1441 ctatctgagg aactggagct ggtggcaagc atcttggagc acaactgtaa tcagacggag
     1501 gaaacaacct ctcccctccc aacaggagta ctctgtgccc tgaagagtga ggatgaggtc
     1561 ctcatcctaa acctggtgca gggctgtggg ctagagctag agaagtctgg ctgccagctc
     1621 ccctgggacc ctacagtggt acctcagctt tctgcactct atgcatgcct cacagggctg
     1681 cagctactga ctgacccaag ccctgggctt tctaggacag tgcctgaaga ggaaacactt
     1741 atctgtccct aaggtctcat ccaacctgac tcctggcagc ctgggatgtc actaaccctc
     1801 tctagtggtc acagctgatg acagggtttc accaggaaag gccccacact acacttaaga
     1861 ctggttccag acatcggaaa cacctattca gaacaagtat cctgaatcag gattctgtct
     1921 gagcagtgca ggctggctgc agaacagttt ggctgtgtat cttaggtagc atagtcccct
     1981 ctgtactcag gtaaaatcag ccattgtaaa atgagatttg tggtcattcc ccaggcacaa
     2041 gaactttgta aaagtatatg tgacatgctt acaagagtgc tgttattgta tggtggcaag
     2101 gtgagaccac agggagaagt agctcttcag ggtaacacag gacaagctgt cctgccttgc
     2161 gtttcctgca ttggcctcct tcgttccatc tgtcacatga caaaacagaa caagctgctc
     2221 aggttccagc ccattgtacc aatgactata caatgtcaga gcatgggatc gagtcagttg
     2281 aataaataag accaggctct tcccagtctt ccttgttaa
//
LOCUS       NM_001437937            8992 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 9, mRNA.
ACCESSION   NM_001437937 XM_039078943
VERSION     NM_001437937.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8992)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8992)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 8992)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 8992)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 8992)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 8992)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8992)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8992)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 8992)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 8992)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078943.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.352365.1,
                                           SRR26360190.853824.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000007.1  136229081-136229132 c
            53-152              JAXUCZ010000007.1  136228828-136228927 c
            153-335             JAXUCZ010000007.1  136227163-136227345 c
            336-522             JAXUCZ010000007.1  136218085-136218271 c
            523-623             JAXUCZ010000007.1  136213218-136213318 c
            624-8992            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..8992
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..8992
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..52
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            53..152
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            153..335
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    175..177
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             199..774
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424866.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    253..402
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    253..402
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(253..264,313..315,319..321,352..354,364..384)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(253..264,313..315,319..321,352..354,364..384)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    544..717
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    544..717
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(571..573,577..591,613..615,640..642,700..702,
                     709..714)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(571..573,577..591,613..615,640..642,700..702,
                     709..714)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(583..585,697..705,709..714)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(583..585,697..705,709..714)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(667..669,679..684,688..693,700..705)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(667..669,679..684,688..693,700..705)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            336..522
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            523..623
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            624..8992
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccctcc tgttagccca gagggaaaga acgaactggg gcgatccggt agggaaggcc
       61 atagccacaa tgcttaactg catgcttcca acatggggct ggttttaacc cagcgctctg
      121 acctaaagtg ctcagctccc ggaaattcca aggaacctgg tggccgcact cctttaggtg
      181 gaccaacaca tacccaacat gggaaagaag accaagagga cagccgacag ctcttcatca
      241 gaggatgagg aggagtatgt ggtggaaaag gtgttggaca ggcgcatggt taaagggcaa
      301 gtggagtatc tgctgaagtg gaaaggcttt tctgaggagc acaacacttg ggaacctgag
      361 aagaacttgg attgtcctga actaatttct gagtttatga aaaagtacaa gaagatgaag
      421 gagggagaga acaacaagcc tagggagaag tcagaaggaa acaagaggaa atccagtttt
      481 tccaacagtg ctgatgatat taaatccaaa aaaaagagag agcaaagcaa tgatatcgct
      541 cggggctttg agagaggact ggaaccagaa aagatcattg gggcgacaga ttcctgtgga
      601 gacttaatgt tcttaatgaa atggaaagac acagatgaag ctgacctggt ccttgcaaaa
      661 gaagctaatg tgaaatgtcc acaaattgtg atagcatttt atgaagagag actgacgtgg
      721 catgcgtatc cagaggatgc ggaaaacaaa gaaaaagaaa gcgcaaagag ctaaaggagg
      781 aggcagtctc tgtcatttct ctttgtatat aataccttca ccttcctgcc tcctctcgct
      841 tctcccgtcc ctttccatcc taaacatatc cataaaaatg atgtgcttat caatcactgt
      901 gctccacggg agagatgttg gtattggttc ccttgtaata taactgatgg tctgactcct
      961 aagtgtagct ctgtgaaagt caggcattac atccttcaca tgctgtgtgg ttcccatagt
     1021 gttctctttc atcctgatct tttccttctg ttccctgtaa cttttaatca ccttagagtc
     1081 gtgatctttg gggttggttg ctttggggaa ttttattata atgacgatga cttcagtttc
     1141 ttggttgtta attagaatat attgatgacc agctggcctt tgttttgaca tactggcata
     1201 gaaaggatgt tgtccagctt ttagaaagct aatagcagca gcctacatgt tgtgtatttt
     1261 ttaatctcac ttagctctgc caggagaata cagggtccct ggtgtggtct tctgggccac
     1321 tcctgactat tctcacctac cctcccataa caactcagtt ctcttgaggg cttgagactt
     1381 tacactgttt agccctcaca ctcttttggc ttcgttactt tcaatccctg attctgcttc
     1441 tgtaaagtgt atcagtttgt tattaaatga caggattaac tgtggggtct gtaagctgta
     1501 gtgcaggacg ataacaggac ggggctggat gcggttgtct ttggtatcac atggtgtgca
     1561 tgtgttcttt ccttcaccct cattcctaga ctctatttat gtaggtgtag ggactgcctg
     1621 gtgcttgctt gtgccaagca ccctgccaac ttttatggcc tcccaaagca ttcctgtacc
     1681 aaagaggaat cagcagatcc acacattccc ttccgtgccg ttattttaag ttgggaattg
     1741 ttagaaagga accattagcc acagtgtcat cagtttctaa atcctcacag cagtgataga
     1801 tactctttaa ctttaccact aagtccctag aggattaatg ttcctgccct ctccatcctc
     1861 agacttttag ttgtagctta ttttaaaaac tattttcatg gaagaccatc gcctcagaaa
     1921 ccaacaggtc ttgacattag ctttttgaca caaccttctc ccacaacaaa ctactccttt
     1981 ttgatttact cttactttgc tattatttct gctcctgttc tgttcttttt gtcccctgaa
     2041 aatgtccatc ttctcttcat tcctttcttc ttatatagtt gaggagactg agaatcagga
     2101 ctaaatgtaa ggaaataaca gggtttggag ctgagcactc tttttttttt ttttcccccc
     2161 cccccggagc tggggaccga acccagggcc ttgcgcttcc taggtaagcg ctctaccact
     2221 gagctaaatc cccagcccca ggagctgagc actcttgacc cagctcaaaa gctgaggaaa
     2281 aggagtaaac gctgagatag ccttaattct agactttatc aactactgag gctgtttttg
     2341 ttgttccttt cggtttttaa agcatagcta tctgagcagc cacccatttc tagatcgttc
     2401 atggtaatga ggggaaggag tggagtgctc tggtccacag atgacccaag tgtgtgcacg
     2461 tcctagaccc attcagtgtt tgctagcatc acttctctgc tcagctgcca ctgagctctg
     2521 tgttcttgaa taaattatgt caacaattat actgcacagt tgacaggaca gccaggaaga
     2581 acctgtgaat ggtactgtgg taggggaaga gcacctaacc cttacctctc cgtagttcat
     2641 tctctgaaga tggtagaggc aagctcaaag gctggataag tgaccattgt ctgcttaact
     2701 tgatgaaatg caggtggtta gagagcagat gtgtccttca cgcaacctag actagtaatt
     2761 agggcagatg aaggtagccc agaagtggcc cagttcctga ggatcttagt ctctgattag
     2821 cagctggagg gaaggacagc ctgctgagca ctcagcagca gtgggctgta aactggcagt
     2881 ggaaggactg agtatacagt ttgaggattt aatgccttgt aatgcaaaaa atgaagggaa
     2941 ggagtggcct gctggtttta atgctcttta caatgttttt ccctctcaaa agttcatgga
     3001 gtattggttt tctgttaatt attaccaaaa ctctcttgtc cgtgtctccc cccccccccc
     3061 cccagctggg gaccgaaccc agggccttgc gcttgctagg caagtgctct accactgagc
     3121 taaatcccca accccttgtt ttcctcttag taagtttcct ggttatatat agaaataggg
     3181 aaccgggatt ccagtattct cttcagctct cagtatgaag aagccagaca cccatttgtg
     3241 cctccagcct gtgttgtgcc aagtagcttg attctgctgg agaattgcag ctgtggacaa
     3301 aagtgtttcc tagagttatc ttctatcttc gctctaaaga gttcatggcc aaaggtgaaa
     3361 gaaatactcc taaacactga ctatattctc ctgtgttaac cctctccaga actaattttg
     3421 tggtactgga aattgaacct aggaccagcg tggacagccg ggcaactgct gtgccatttt
     3481 tgtctgcccc ctttcctccc ctgccataca gttgatggat caccaaattc acctgttttt
     3541 gttgctctaa ggactttaag tcactgatac caagctaacc ttggttgtat aaccaagttg
     3601 aattcttttt tttttttttt taaacttatg tgactatgtt gttgctgtct tcagacacac
     3661 cagaagaagg catcggatca cattacagat ggttgtgagc caccatgtgg ttgctgggat
     3721 ttgaactcag gacctctgga agagcagtca gtgctcttaa ccactgagcc atcctccagc
     3781 cctgctaagt tgaattcttt ttttcttttt ttctttttct ttttcttttt tccgaagctg
     3841 gggaccgaac ccagggcctt gcgcttgcta ggcaagcgct ctaccactga gctaaatccc
     3901 caacccccta agttgaattc ttgatctcct gcctcttccc agtctctagg attataggta
     3961 tgtgccacca tatctggctc ttagctcctt ctatatggag ttatctgtgc tagccaggta
     4021 cagtgtaata cacctttatt tccagtcttt aggaggcaga agtagataaa tcttaatcgg
     4081 aggcctgcct ggactatata gtgagttcta ggccagccac acctacatag atcttgttgt
     4141 gaaaggaaaa ataggaaaag agtacccaga ttggccttga acttaggatc tttatgtatc
     4201 agttgtatgc cactatgcct ggctcaaaat gccttttttt ttctttatta acttgagtat
     4261 ttcttattta catttcgatt ttttttaagt tatatatata tgtgatttct gcctgcatgt
     4321 atatgcacca tatgcatgcc tggttcccta ggagacagaa gagggtctca tatcctctta
     4381 gataggagtg agccactatg tgggtgttga gaatcagatc tggaagagta gtcagtgctc
     4441 ttaactgctg agccatctcc cacccttcaa aacatctttc taaagttgaa tttcttcccc
     4501 cccccctttt ctgtttagtc ctgactgttt cttgctggct tcaccctcta gtgctcacgt
     4561 tttgctagct ttgtgcaaaa acaggtgaac tgggtgatcc atcctcaatt ttacacattg
     4621 tgttgttcac atttctacaa ctttagcata catcaatatt gttttcattc aacaaacagt
     4681 tttggctcag gaactcgcta gagaactttg atagtggtgt gggatgagtt gatcagtata
     4741 gttttggata atgaatactg cacatgtata taaattactg gtctgggaca gcatcaggta
     4801 tacaaaaagg tgagtcttta gtgggcagtt agttaagtgg ttgagtgctg gtgaggaatc
     4861 catgaagccc tgggtttcca cggggggggg ggtaaggtaa atctgcagta ggaggggggg
     4921 gtaaggtaaa tctgcagtag gagggggggg taaggtaaat ctgcagtagg agggtgccat
     4981 taactgcttc atctgtggga aagactgtgg tcttggatga actgagttaa ctggccatgg
     5041 gcagcattgc aggaaataaa gctagaaagg ctttcgtttc gttaccaaga gtgcagatga
     5101 atgagcgtga gaactgtctt gtttagactg ccaagcattc atgactgtgt tagtattgcc
     5161 tgtgctggtg tatatttctt ctttgtgggc gttttagcaa gttgctcaca ctgttcaatt
     5221 tctcaccctt ttggagaaat caacattagt ctggctttaa agcccaaaac ataccatcta
     5281 atgacaagac ttccttagaa caaagcttag gaatgagcta cctttggatc acgtgggtct
     5341 cagtgccagg gagtaagcag ctcctgtgtc acttatatca aaaccttcca caggaataat
     5401 gtgctctggc tcctcattgt gcgtgacacc cttctcagag aaggaaaggt ctgtttttca
     5461 ggttcttatt ctgactcctg agagcccaag acgaagatgt aattgactga ctttagaagt
     5521 cagaattccc agaaattcaa ctaactgctc tagaaggtta aaatgtgaag tttcttgttt
     5581 gttttttgct tgtgctgaat attttgaatt ttcatctacc tcgtcttatt tttcttagtt
     5641 acttctgtca ttaccacttg agcatcaagc ttgattttgg tcattgtcta aaatggggtc
     5701 tctcctgttc agtgacagtt tattcccttg tctttcctct tggccctcat ttcacctaac
     5761 atcatctctt attgctcctg tcagaaatat gttttaaagt cttgttttat gggaaaaagt
     5821 ggtccaccaa tgctgtttgt ctctgaggtc agtgagagaa ggagttaaaa cacagtggtg
     5881 gaggaagggc agagcctgcc tgcactggag gcaaaagctg acaaggaagg agtcattaat
     5941 taaagacaat ttcaaagtca actgattgtg atcattaatg tcacaataga tcaaaaccta
     6001 attatcacag cctaggtaag agccatcagt attaatcgga aaatctaata ggaaactatt
     6061 agcaagaaat taggccaaat tgaatgcaat gaacttttta tcatcttttt ttggtaatgt
     6121 tcttggtgtt ggcaactgtg accctaacag ttggtccaag cccagattgc taattttaaa
     6181 gagccttttt tttttttttt tttaagtaac ccaggctgac cctagtgctt acagccctcc
     6241 agcttcagcc ttgagcactg ggattatgag gggtacatgc atttgtgttt gtgtgggtgg
     6301 gtaggagaga attgaactca gggccttgta cattttagac aagtgctcta ccactgaact
     6361 gtattcctag ctcagagtgt tttgtttgtt agggaagttt ccagacagac tgaacctaag
     6421 ctgacattgc tgaaacacca gccttgaatt tttttatcat atggatctat tcattctaat
     6481 cagatcagcg ggatataaac atatatatta aagtcgtaga gtgtccctag tgaacatcat
     6541 atcatctgtt gagtgcttgt atatagagtt ctatactggt tgttgtgaag gctgtgggag
     6601 gaaggcagtg tcctgctttg aaattctttg aaaactaaaa agatagtttc cttgtgtgac
     6661 agcatgatca agatgcaagt ctgtgttttt cagtttccat tagcattagg gtttgatcct
     6721 aaaccagctt agcagtgccc ccaaccccaa tagttttaag ataggcacaa aatgatttcc
     6781 tactggaatt ctaaggtatg gggaagacat ctttgtttct gttttccttt ctggtagtag
     6841 gagaagcatc agtatgtcct taagatgttt gtaaagatgc tacccccttt aggtgagatg
     6901 agtcaggctg tggaacggtt gctgtcacag gaggagtgcc aggcagtagt agagggaatt
     6961 gtgcttagga gtctgcactg tgccctgcag ccctcagatg ctcagtgctg accttaggag
     7021 gcccatgctg ctttctggac cttgggaacc tggattaccc agtagaagac tgagaatcaa
     7081 tgtcttttgt ttgtttgttt attttttgtt ctgtttttgt tttgttttgt tttgttttcc
     7141 aagatggggt ctctgtgtag ccatggatgt cctggaactt gctctgttga ccagactggc
     7201 ctcgaactca aagatctgcc tgcccctgcc tcccaagtac tgtgatcaaa cgtgtgcgcc
     7261 atcactgcct ggctaaccct tcacttctta gtgagtttta gtgtttaaaa aatgcaactt
     7321 aattttcaaa gtggcactaa ggtggtttgt ccagccttgg gttactccag gtgagcagca
     7381 gccctcaatt aacagtgtgt tgattggact catccggctg cagtgaaatg actgaaagtg
     7441 agatgttcta gtgcatagtt ctgtgctaac ctcctacttg gtcttaatgg ctgaccttgg
     7501 gcaagtcttt cctttcaatg cctcagttcc ccatctgtca aatggggtga taatactgac
     7561 ctacctcatg gggtgttgtg aggcattaca gatcagagct gatcaaccct ttaggattgc
     7621 ctgtggagga taccttaagt cggactcttt tagccctcac tgagctactt ccaagtttgg
     7681 aagtagttag tgaccttggc gagtttctgt ccccccaccc tttacccctc atcaaagctg
     7741 ctagttcaga tgttaacagt gttttgtgaa tgttggagtc ttgatcgtcc agtctaactt
     7801 gggacaatgt aagggaaggc acttgtgggt tctgtgtctt atattacaaa gagactgtta
     7861 gaaattcaag agccttggtt taggaatctt gaggcaggaa tgctaccgca tgtctttctc
     7921 tgcaggagtt aaggtcctat tctcatggac ttataactac ttctgactgt cttcgaaagg
     7981 aagtgacact tggtattttg gatttatatt gttgctttca ttttccagac tgatcctagg
     8041 acagttagtc tactgaaccc ttcatgcttc tatgcctctg ccctctcata gaagccagat
     8101 ggttcaagca acatagctct cccttccccc accaaaaagc tgtattggat ttttgttttt
     8161 ttgtttctag aaataggtgt aacatttcag aattgagcat tggtcctcaa ggcttcttcc
     8221 agttcactgt gtgtggaatc tgtcacctct tttcagtgtc caccatctga cccactgagg
     8281 acatcttgga cacttgtttg cccacttgag ggttcaaaag ccttactctg tgtttcagta
     8341 tagggctaag gcatccccaa gctcttcgtg ataggtttcc tttcccctac ttgaccttgt
     8401 attggtacca tgaaaaagca cacagtccta gctccctgga ggtacacact ccagtactgt
     8461 taggtggact ctactcctaa cagggatcct agagggttct ctggaggatg ggaaaggagc
     8521 agtctcatgt cctgccaagt agtagccagc agttgcctta cccctgcctg ctggccatgt
     8581 tcccacctcc tcatggagag ggctttcaga ggtcctcgag gctggatttt ctcagtctct
     8641 gctgtgccat tctgagtggg aagcagacca cactttgtgg ccaggtgtct aagtggaagt
     8701 gaggtcttga attctcggtg gactttttgg tttgtggggg agttttggtt gtgtttcttg
     8761 gttctatttc agccaaactc gcctgctttt gatttcttta aaggataagt ggtctatcta
     8821 tctatataca tgtatgtttg cattttaagt gtaaatgttt tgaaaaaaaa aaacagacat
     8881 gtctttctat aactgacatc cgattcagac atcattctct ccccttccac cctcttttcc
     8941 ctcttttcat actcttgtat tggttctaat aaaggattgc ttttcaaata tg
//
LOCUS       NM_001437980            1681 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            9, mRNA.
ACCESSION   NM_001437980 XM_039079164
VERSION     NM_001437980.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039079164.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1673690.1,
                                           SRR26360186.948703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-190              JAXUCZ010000007.1  97509983-97510127
            191-488             JAXUCZ010000007.1  97510569-97510866
            489-675             JAXUCZ010000007.1  97512128-97512314
            676-850             JAXUCZ010000007.1  97512838-97513012
            851-956             JAXUCZ010000007.1  97515701-97515806
            957-1004            JAXUCZ010000007.1  97516474-97516521
            1005-1180           JAXUCZ010000007.1  97517084-97517259
            1181-1322           JAXUCZ010000007.1  97517640-97517781
            1323-1396           JAXUCZ010000007.1  97518224-97518297
            1397-1681           JAXUCZ010000007.1  97519504-97519788
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1681
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..190
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            191..488
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1651
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 2 is encoded by transcript variant 9;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 2"
                     /protein_id="NP_001424909.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELAQELCKSICDMLTRVL
                     LLYGGKVRPQGEVALQGNTGQAVLPCVSCIGLLRSICHMTKQNKLLRFQPIVPMTIQC
                     QSMGSSQLNK"
     misc_feature    278..982
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    278..982
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    1040..>1408
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    1040..>1408
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            489..675
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            676..850
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            851..956
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1004
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1180
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1322
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1396
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1681
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgagacagg tgaatcccag
       61 agcccacctc agggaggtcc tggcttcaat gtcaagaaaa ccatgataca acgcaactgg
      121 agataagagg aaactggagt ccaccttagg tccttccgca caggaatttg tacaaccaca
      181 gggaaagcaa atcaggccag cttgcagcta tcacgaaggg atcccatatc cagcccggga
      241 tgatattgtc ccttgcctct caaggagcat gtcatctctg ttcttgagga gcaccaaaag
      301 cctggtgaga gagctgggca ggaagggtga gctggtgccg gtagacagcc tgaacagttc
      361 acagcgcctg cgccccttct gcctggtgag gaagaagcac aagcattccc tctggccttg
      421 ggacacaccc ctcatcccca cagacttctc cctgctggat gtgctggagc ctggctgccc
      481 tgacccagag gtgaaccaca gcaagcccat ctattcctgg gagaaggagg cagagggatt
      541 gacaggagct gtgagcgtga gtgctgggct gcagagccag gtgactggaa gcggcacgac
      601 cacctgcctc tctgccttgg cggtgcagac actctgggtc tccccgttta cctgggagat
      661 gcttcttgag aaaaggaaac tgaggtcgcc taggccctcg ttcctccagg aactacagag
      721 ccggaaggag agggagagcc tatatgtggt gaccgaggct gtggagaccc tgcaagatac
      781 catacttcag agccacgacc aaatgcgagg agccggacag ctgtccctcc tacagctggg
      841 ccatgttcag gtccagggac agagccatgt ggacacagag aagatggtga gcatcccaca
      901 gggcagtgtt ctggcctaca gggttctgca gctagtggtg gaagaagatg gctgggctgt
      961 cctttacttc cctgaaagaa agctctgcag gaatgccaga gtagctatag ccttcagcca
     1021 ggaatcagga gaagagtcta acttctacag cttgcgggac caagcagata gccagttgca
     1081 ggacctggtc acattatcct cagagcgacg ggccacattg cttggtgccc tccaggagct
     1141 actacgggat cagcaggcac tccaggagct agaggatacg ctggaacagg ctctggacac
     1201 agggctgctg gcacagctgg agggccctgg aggctgtgtc ttatgcatcc tccaagactc
     1261 tacaagcaac ttgtcatgct cgaaaggcag ggctatcctc tatattcttg gagccttagc
     1321 agcactgagt gaaccccagc attgcctgct ggcccagtcc atagagagac aaatcctatc
     1381 tgaggaactg gagctggcac aagaactttg taaaagtata tgtgacatgc ttacaagagt
     1441 gctgttattg tatggtggca aggtgagacc acagggagaa gtagctcttc agggtaacac
     1501 aggacaagct gtcctgcctt gcgtttcctg cattggcctc cttcgttcca tctgtcacat
     1561 gacaaaacag aacaagctgc tcaggttcca gcccattgta ccaatgacta tacaatgtca
     1621 gagcatggga tcgagtcagt tgaataaata agaccaggct cttcccagtc ttccttgtta
     1681 a
//
LOCUS       NM_001437906            1832 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus aladin WD repeat nucleoporin (Aaas), transcript
            variant 2, mRNA.
ACCESSION   NM_001437906 XM_008765705
VERSION     NM_001437906.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Carvalhal,S., Ribeiro,S.A., Arocena,M., Kasciukovic,T., Temme,A.,
            Koehler,K., Huebner,A. and Griffis,E.R.
  TITLE     The nucleoporin ALADIN regulates Aurora A localization to ensure
            robust mitotic spindle formation
  JOURNAL   Mol Biol Cell 26 (19), 3424-3438 (2015)
   PUBMED   26246606
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Huebner,A., Mann,P., Rohde,E., Kaindl,A.M., Witt,M., Verkade,P.,
            Jakubiczka,S., Menschikowski,M., Stoltenburg-Didinger,G. and
            Koehler,K.
  TITLE     Mice lacking the nuclear pore complex protein ALADIN show female
            infertility but fail to develop a phenotype resembling human triple
            A syndrome
  JOURNAL   Mol Cell Biol 26 (5), 1879-1887 (2006)
   PUBMED   16479006
REFERENCE   6  (bases 1 to 1832)
  AUTHORS   Brooks,B.P., Kleta,R., Stuart,C., Tuchman,M., Jeong,A.,
            Stergiopoulos,S.G., Bei,T., Bjornson,B., Russell,L., Chanoine,J.P.,
            Tsagarakis,S., Kalsner,L. and Stratakis,C.
  TITLE     Genotypic heterogeneity and clinical phenotype in triple A
            syndrome: a review of the NIH experience 2000-2005
  JOURNAL   Clin Genet 68 (3), 215-221 (2005)
   PUBMED   16098009
REFERENCE   7  (bases 1 to 1832)
  AUTHORS   Storr,H.L., Clark,A.J., Priestley,J.V. and Michael,G.J.
  TITLE     Identification of the sites of expression of triple A syndrome mRNA
            in the rat using in situ hybridisation
  JOURNAL   Neuroscience 131 (1), 113-123 (2005)
   PUBMED   15680696
REFERENCE   8  (bases 1 to 1832)
  AUTHORS   Cronshaw,J.M. and Matunis,M.J.
  TITLE     The nuclear pore complex protein ALADIN is mislocalized in triple A
            syndrome
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5823-5827 (2003)
   PUBMED   12730363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_008765705.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.28962.1,
                                           SRR26643293.43512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000007.1  135355808-135356096 c
            290-417             JAXUCZ010000007.1  135355309-135355436 c
            418-473             JAXUCZ010000007.1  135351834-135351889 c
            474-565             JAXUCZ010000007.1  135351461-135351552 c
            566-612             JAXUCZ010000007.1  135351293-135351339 c
            613-711             JAXUCZ010000007.1  135350514-135350612 c
            712-855             JAXUCZ010000007.1  135348996-135349139 c
            856-976             JAXUCZ010000007.1  135345069-135345189 c
            977-1101            JAXUCZ010000007.1  135344702-135344826 c
            1102-1162           JAXUCZ010000007.1  135344497-135344557 c
            1163-1253           JAXUCZ010000007.1  135344262-135344352 c
            1254-1347           JAXUCZ010000007.1  135344041-135344134 c
            1348-1415           JAXUCZ010000007.1  135343902-135343969 c
            1416-1497           JAXUCZ010000007.1  135343541-135343622 c
            1498-1582           JAXUCZ010000007.1  135343368-135343452 c
            1583-1832           JAXUCZ010000007.1  135342910-135343159 c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1832
                     /gene="Aaas"
                     /note="aladin WD repeat nucleoporin"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
     exon            1..289
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1807
                     /gene="Aaas"
                     /note="isoform 2 is encoded by transcript variant 2;
                     achalasia, adrenocortical insufficiency, alacrimia
                     (Allgrove, triple-A)"
                     /codon_start=1
                     /product="aladin isoform 2"
                     /protein_id="NP_001424835.1"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
                     /translation="MCSLGLFPPPPPRGQVTLYEHNNELVTGNSYESPPPDFRGQVVG
                     VGDAAWINLPVLHLTKDPLKAPGRLDHGTRAAFIHHREQVWKRCINVWHDVGLFGVLN
                     EIANSEEEVFEWVKTASSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSC
                     CLRVFAWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLA
                     VACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPNGGWLLSASPVDAV
                     ILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWTCEGWPT
                     LSGRCQTGCWSPDGKRLLFTVLGEALIYSLSFPEPCGTEKGHVGGAKSATIVADLSET
                     TIQTPDGEERLGGEAHAMVWDPSGERLAVLMKGNPRVQDGNPVILLFRTRNSPVFELL
                     PCGVIQGEPGAQAQLVSFHPAFNKGALLSVCWSTGRITHIPLYFVNAQFPRFSPVLGR
                     AQEPPAGGGGSVHEVPLFTETSPTSAPWDPLPGLPSAQPHSPHSHL"
     misc_feature    635..745
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    635..745
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    <638..1417
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <638..1417
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    755..895
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    755..895
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    905..1015
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    905..1015
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1037..1150
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1037..1150
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            290..417
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            418..473
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            474..565
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            566..612
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            613..711
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            712..855
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            856..976
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1101
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1162
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1253
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1347
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1415
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1497
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1582
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1832
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttccgt tcagcttcac gcagtagttt gtcctgtacg gctacccgtc cgcatacgaa
       61 tctagcccgg gaactaagat tcaagagagc gcagtcacca gccgggagcc tgtcggttcc
      121 agacaccctc cggactgaca agatgtgctc cctggggttg tttcccccgc cgccgcctag
      181 aggtcaagtc accctgtatg agcacaataa cgagctggtg accggcaaca gctatgagag
      241 cccgcctccc gacttccggg gccaggtggt cggggttggg gatgcggcgt ggatcaatct
      301 tcctgtccta cacctgacca aggatcccct aaaagctcct gggaggctgg accatggtac
      361 aagagctgcc ttcatccatc atcgggagca agtgtggaag aggtgcatca atgtttggca
      421 cgatgtgggt ctttttggag tcctgaatga aattgcaaat tcagaggaag aagtgtttga
      481 gtgggtaaag acagcctcca gctgggccct ggctctctgt ggccgggcct cctccctcca
      541 tggctccttg ttcccacacc tctcactcag gagtgaggat ctgattgctg aatttgccca
      601 agtcactaac tggtccagct gctgcttacg ggtctttgcc tggcatcctc acaccaacaa
      661 gtttgcagtg gccctgctgg atgactccat ccgtgtttat aatgccaaca gcactatagt
      721 tccctccctg aagcaccgtc tacagcgaaa tgtggcagca ctggcctgga agcccctcag
      781 tgcctctgtc ttggctgtgg cctgccagag ctgtattctc atctggaccc tggaccccac
      841 ttccttatct acgagaccct cctctggctg cgcccaggtc ttgtctcacc ctgggcacac
      901 accagtcacc agcttggctt gggcccccaa tggggggtgg ctgctctcag cctcaccggt
      961 agatgctgtt attctggtat gggacgtttc aacagaaacc tgtgtccccc ttccttggtt
     1021 ccgaggagga ggggttacca acttgctgtg gtccccagat ggcagcaaag tcctggctac
     1081 aactccttcc gctgtctttc gagtctggga ggcccggatg tggacttgtg aggggtggcc
     1141 aactctctca gggcgctgcc agactggctg ctggagtcca gacggaaaac gattgttgtt
     1201 cactgtattg ggggaagcat taatttattc cttgtcattc ccagaaccat gtggaacaga
     1261 gaaaggacat gttggaggtg caaagtcagc caccatcgta gcagatcttt ctgagacaac
     1321 aattcagacc ccagatggag aggagagact cgggggagag gctcacgcca tggtttggga
     1381 ccctagtggt gaacgactgg ctgtgctcat gaaaggaaac ccacgggttc aggatgggaa
     1441 tcctgtcatc ctcctttttc gaactcgaaa cagccccgtg tttgagctgc ttccctgtgg
     1501 tgttattcag ggggagccgg gagcccaagc ccagctcgtc agcttccatc ctgctttcaa
     1561 caaaggggcc ttgctcagtg tgtgctggtc cacaggccga atcacccaca tccctctgta
     1621 ctttgtcaac gcccaatttc cacgctttag cccagtgctt ggtcgggccc aggagccccc
     1681 agctggaggt ggaggctctg ttcatgaagt accactattt actgagacat caccaacctc
     1741 tgccccttgg gaccctcttc caggactacc atctgctcaa ccccactccc ctcactccca
     1801 cttgtaaata aagtttttct tgtttccact ca
//
LOCUS       NM_001437901            4124 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 8, mRNA.
ACCESSION   NM_001437901 XM_039078867
VERSION     NM_001437901.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4124)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078867.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230825.1, SRR26643295.29795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-339             JAXUCZ010000007.1  122193494-122193621
            340-495             JAXUCZ010000007.1  122194723-122194878
            496-738             JAXUCZ010000007.1  122203808-122204050
            739-925             JAXUCZ010000007.1  122207498-122207684
            926-1063            JAXUCZ010000007.1  122210547-122210684
            1064-1129           JAXUCZ010000007.1  122213276-122213341
            1130-1242           JAXUCZ010000007.1  122216165-122216277
            1243-1356           JAXUCZ010000007.1  122216625-122216738
            1357-1483           JAXUCZ010000007.1  122218925-122219051
            1484-1636           JAXUCZ010000007.1  122220112-122220264
            1637-1852           JAXUCZ010000007.1  122223641-122223856
            1853-1917           JAXUCZ010000007.1  122225088-122225152
            1918-2033           JAXUCZ010000007.1  122226909-122227024
            2034-2119           JAXUCZ010000007.1  122228286-122228371
            2120-2217           JAXUCZ010000007.1  122229298-122229395
            2218-2275           JAXUCZ010000007.1  122229728-122229785
            2276-2397           JAXUCZ010000007.1  122230077-122230198
            2398-2561           JAXUCZ010000007.1  122230444-122230607
            2562-2718           JAXUCZ010000007.1  122231523-122231679
            2719-2807           JAXUCZ010000007.1  122231770-122231858
            2808-3003           JAXUCZ010000007.1  122232571-122232766
            3004-3231           JAXUCZ010000007.1  122235416-122235643
            3232-4124           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4124
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..339
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    317..319
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            340..495
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..738
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..3280
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 2 is encoded by transcript variant 8;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 2"
                     /protein_id="NP_001424830.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLAFSEYQIQQMTANFVDQFGFNDEEFADQDD
                     NINAPFDRIAEINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARV
                     MARARFGAPHTSENYSKKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDS
                     AGTTWTAVFDEPVNPLSAASGAARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETG
                     PRCSSPVDMDHSNAEGGQSPGPEKAFGPTSPCAWNVCVTRKAPLVASDSSSSGGSDSE
                     DDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRAECPDSTVLAPACPAPSEVTISPAV
                     ATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAIVATLGTMTKDRKTDALPD
                     GAALNGPV"
     misc_feature    893..2113
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    893..2113
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2363..>3250
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2363..>3250
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            739..925
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1063
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1129
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1242
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1356
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1483
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1636
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1852
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1917
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2033
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2119
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2217
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2275
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2397
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2561
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2718
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2807
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..3003
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3231
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..4124
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggtaaaccaa ccaaaactct ttgcagaatg
      241 aaaacacctt ttttaaaatt gcatgtatac aaaagaaaga gcccaaatgc tttttatttt
      301 gcctgaatac aagatttaaa caaggtattg ccatagaagt ctctaccaca gcgcgttctg
      361 ttggactctt tcacggaact ataggatcac atgggcagca cttgtgtttg attctaccct
      421 ctttcttccg gtcggttctg tcaccctggg aaatagagaa gcagaacgta cggctccttt
      481 cttcattcac tgctgctctg tgaccaccat catgttctgg aaatttgact tgaataccac
      541 gtcccacgtt gacaagctcc tcgacaagga acatgtgaca ctgcaggaat taatggatga
      601 agatgacatc ttgcaagagt gtaaggctca gaaccagaag ctgctggact tcctgtgcag
      661 gcagcagtgt atggaggagc tggtgaacct catcacacaa gacccacccc aggacatgga
      721 agagaaggtc cgattcaaat atccaaacac agcctgtgag cttctgactt gtgatgtgcc
      781 gcagatcagc gacagactag gcgaggacga gagtctgctg aaccttctgt atgacttctt
      841 ggaccaggag ccaccactca accctctgct tgccagtttt tttagcaaga ccattggcaa
      901 tctcattgca aggaaaaccg aacaggtgat catgttcttg aagaagaagg acaagttcat
      961 cagtctgata ctgaagcaca taggcacctc agctctcatg gacctgctgc tacgcctggt
     1021 cagctgcgtg gaaccagttg ttctccggca ggaggtccta cattggctta atgaagagaa
     1081 agtcatccag agacttgtgg aattgatcca tccccaccag gatgaagata ggcagtcaaa
     1141 tgcttctcag gcactctgtg acatcatcag gctgggcaga gaccagggca gtcagctgca
     1201 ggagactgtg gagccggatc ccctcctcac agcactggag tcgcaggact gtgtggaaca
     1261 gcttctgaag aacatgtttg atggggatcg gacggagagc tgcctggtca gtgggatgca
     1321 ggtgctgctt gccctgctgg agccaaggcg tgttggaaca gaaggcttgg tggactcctt
     1381 ttctcaggga ctggaaaggt catactctgt cagcagcagc atcctgcacg gcattgagcc
     1441 atggctgaag aatttccatc agctcctgct caacccacca aagaagaaag caatcctgac
     1501 cactattggc gtgctagagg agcccctggg gaatgctcgt cttcatggtg cacgcctcat
     1561 ggctgcactg ctgcacacaa atacgcccag catcaaccag gagctctgcc ggctcaacac
     1621 catggactta ctgctggacc tgttttttaa gtacacctgg aataacttct tacacttgca
     1681 agtggagctg tgcatagccg ctattctctc ccacgctggt cgggaggagc aggcagaagc
     1741 tggcagatca gatggcaaag tggaacctgt gcaggggagt ggagatgggg gtgggaagcc
     1801 ggagaccacc ccgtccatca ccagccctcc tgagaacaca atggtgaccc atctgttcca
     1861 gaagtgctgc ctggttcaga ggatcctgga agcctgggaa gccaatgaca acacacaggc
     1921 ggcaggtggc atgagacgtg ggaatatggg ccacctcaca aggatcgcca acgcagttgt
     1981 acagaacctg gagcagggcc cggtgcagac acacatcagt gaagtcatcc gagggctccc
     2041 tgcagagtgc cgtggacgct gggagagctt tgtggaagag acactgatgg agaccaaccg
     2101 caggaacact gtggacctgg ccttctctga gtaccagatc cagcagatga cagcaaactt
     2161 tgtggatcag tttggcttca atgatgagga gtttgcagac caggatgaca acatcaatgc
     2221 cccatttgac cggattgcag agatcaactt caacattgaa gccgatgagg acagtcccag
     2281 tgcagctctg tttgaagctt gctgcagtga tcggatccag cccttcgatg atgacgagga
     2341 ggacatttgg gaggatgagg agactcgatg cacggcccgg gtgatggcca gagccaggtt
     2401 tggagcccct cacacctcag aaaactactc aaagaaggcc gtgggacatg gaggccaggg
     2461 caggaagact ggctccccca cagctaggaa tgtgcctgga ctggccacgc cttcatcccc
     2521 tacacagaaa gaaggtcctc gctcagaaag tgattcagca ggtactacat ggacagcagt
     2581 ttttgatgag ccagtgaacc cgctgtctgc agcctcagga gctgcgaggg atgtgggttc
     2641 tagtgcatgg gcggctggtc cttcagttgc agaggagaaa ggctgggcca aattcaccga
     2701 cttccagcct ttctgctgct ctgagacagg gccccggtgc agctctcctg tggacatgga
     2761 ccacagcaat gccgagggtg gccagagtcc aggcccagag aaagcctttg gtcctacctc
     2821 gccttgtgcc tggaacgtgt gtgtcactag gaaggcccca ctggtagcct ctgacagcag
     2881 ctcctctggg ggatctgaca gtgaagatga cgagaaggca gcgggtgctg tggaagctct
     2941 gtgcgcaggc catactggaa aggcctcccc gccacccagg acagcagagg ctgctgctgg
     3001 cagggccgag tgtcctgaca gcaccgtgtt agcccctgcc tgccctgctc cttcagaagt
     3061 gaccatcagt cctgccgtgg ctaccatagc accaagcaag gcaggctctc ccacagccac
     3121 catagtggtc tcttcctcag tggctactgc ggtaccccca ggaccaatca tggcagtaac
     3181 cacaacagct ccagccatag ttgcaaccct ggggacaatg acaaaggaca ggaagacaga
     3241 tgccctgcca gatggagctg ccttaaatgg ccctgtgtaa tggctgccgc ccagctatgg
     3301 cccaccctgg tcaggctgcc tccttaatca agaagactac ctggtgatgc aatttttttt
     3361 aatttaactt taaaataaat gctgcatttg gtaaagctgg cagtggaacc cgttggatga
     3421 cccagctcat gtttctcctg cctgcccttg gtcctgttgg aggacaggat gcacctggcc
     3481 attcccaggc ccaggtcttg gtgtggcaat gcagccctga cgcgcagctt caacctgcag
     3541 gagttgggga gggaacaaga ccctaagggg ccagcaccat cggatgggca ggaagggtgc
     3601 ggatctccag gcgctggttt catctgtatt tttaacgcat ggaggaaaag ccgttttttg
     3661 cactttgtac ccagctacag tacagggtct ctctaggctc agggcagatg tacaggcctg
     3721 agttggagag acctgatccc cactaataat actacatggg ggtctggcac tagtttggcc
     3781 acatgaggtc aaaccccagt tctagctgcc cagggactcc tgggagctgg tgttgaatca
     3841 ggctacacat tttgactgcc ttaaaaacaa agaccctctg gacccggtgc agtggtctct
     3901 gtgctcagca gggcagactg gcacactcgg gtgggggttg gagctgcacc agacatgtaa
     3961 gagtggacac ggaagagcac tgggaggcct agggaccggg cgggcccata gtgtccagga
     4021 agagtctaaa gtctatgttg tctttttttt tttttttttt taaatgttct gaccttctga
     4081 cagggcatct aacccccaat aaaaaggatc attcttactg aaaa
//
LOCUS       NM_001033702            1584 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 126 (Rnf126), transcript
            variant 2, mRNA.
ACCESSION   NM_001033702
VERSION     NM_001033702.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Huang,C.Y., Lee,F.L., Peng,S.F., Lin,K.H., Chen,R.J., Ho,T.J.,
            Tsai,F.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain
            IGF-IIR expression for hypertension-induced cardiomyocyte
            hypertrophy
  JOURNAL   J Cell Physiol 233 (2), 979-989 (2018)
   PUBMED   28383811
  REMARK    GeneRIF: Angiotensin II activates ERK/GSK3 to phosphorylate HSF1,
            resulting in RNF126 degradation, which stabilizes IGF-IIR protein
            expression and eventually results in cardiac hypertrophy.
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Rodrigo-Brenni,M.C., Gutierrez,E. and Hegde,R.S.
  TITLE     Cytosolic quality control of mislocalized proteins requires RNF126
            recruitment to Bag6
  JOURNAL   Mol Cell 55 (2), 227-237 (2014)
   PUBMED   24981174
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Smith,C.J. and McGlade,C.J.
  TITLE     The ubiquitin ligase RNF126 regulates the retrograde sorting of the
            cation-independent mannose 6-phosphate receptor
  JOURNAL   Exp Cell Res 320 (2), 219-232 (2014)
   PUBMED   24275455
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   Delker,R.K., Zhou,Y., Strikoudis,A., Stebbins,C.E. and
            Papavasiliou,F.N.
  TITLE     Solubility-based genetic screen identifies RING finger protein 126
            as an E3 ligase for activation-induced cytidine deaminase
  JOURNAL   Proc Natl Acad Sci U S A 110 (3), 1029-1034 (2013)
   PUBMED   23277564
REFERENCE   6  (bases 1 to 1584)
  AUTHORS   Zhi,X., Zhao,D., Wang,Z., Zhou,Z., Wang,C., Chen,W., Liu,R. and
            Chen,C.
  TITLE     E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by
            targeting the tumor suppressor p21 for ubiquitin-mediated
            degradation
  JOURNAL   Cancer Res 73 (1), 385-394 (2013)
   PUBMED   23026136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001033702.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099810.1, SRR26643299.29881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000007.1  10590071-10590205
            136-194             JAXUCZ010000007.1  10594365-10594423
            195-303             JAXUCZ010000007.1  10594526-10594634
            304-548             JAXUCZ010000007.1  10594736-10594980
            549-617             JAXUCZ010000007.1  10595420-10595488
            618-687             JAXUCZ010000007.1  10595554-10595623
            688-781             JAXUCZ010000007.1  10595873-10595966
            782-897             JAXUCZ010000007.1  10596049-10596164
            898-1584            JAXUCZ010000007.1  10596899-10597585
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1584
                     /gene="Rnf126"
                     /note="ring finger protein 126"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
     exon            1..135
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1047
                     /gene="Rnf126"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF126"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF126 isoform 2"
                     /protein_id="NP_001028874.1"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
                     /translation="MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEET
                     RNTENGSAPSTAPTDQNRQPFEVRQGPWAQARPPVLQNVDQHLFTLPQGYSQFAFGIF
                     DDSFEIPAFPPGAQADDGRDPESRREREHQSRHRYGARQPRARLTARRATGRHEGVPT
                     LEGIIQQLVNGIISPAAVPSLGLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTG
                     PPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGERVRQLPCNHLFHDSCIVPW
                     LEQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS"
     misc_feature    88..180
                     /gene="Rnf126"
                     /note="zinc-ribbon; Region: zinc_ribbon_9; pfam14369"
                     /db_xref="CDD:433910"
     misc_feature    88..180
                     /gene="Rnf126"
                     /note="zinc-ribbon; Region: zinc_ribbon_9; pfam14369"
                     /db_xref="CDD:433910"
     misc_feature    793..924
                     /gene="Rnf126"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 126 (RNF126) and similar proteins; Region:
                     RING-H2_RNF126; cd16801"
                     /db_xref="CDD:438453"
     misc_feature    793..924
                     /gene="Rnf126"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 126 (RNF126) and similar proteins; Region:
                     RING-H2_RNF126; cd16801"
                     /db_xref="CDD:438453"
     exon            136..194
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            195..303
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            304..548
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            549..617
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            618..687
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            688..781
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            782..897
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1584
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaaacggc cggcggcagg cgccgcgcgg ggggcgggcg gcgcggaggc ggcggtggcc
       61 atggctgagg cgtcgccgca gcccggacgg tacttctgcc actgctgttc ggtggagatc
      121 gtgccgcgcc tgccggatta catctgccca cggtgcgagt ctggcttcat cgaggagctt
      181 ccagaagaga ccaggaacac agaaaacggc tcagccccct ccacagcccc tactgaccag
      241 aaccggcagc catttgaggt gcgtcagggt ccctgggccc aggcccgccc tcctgtcctg
      301 cagaatgtgg accagcacct gttcacgctg ccacagggat acagccagtt tgcttttggc
      361 atcttcgacg acagctttga gattcccgcg ttccctcctg gggcccaggc cgatgatggc
      421 agggaccctg agagccgacg ggagagagag caccagtctc ggcatcggta tggggcccgg
      481 cagccccgtg cccgcctcac tgcccggcgg gccactggcc ggcatgaagg cgtccccacg
      541 ctggaaggga tcatccagca gctcgtgaat ggcatcatct ctccagctgc cgtacccagc
      601 ctgggccttg gtccctgggg cgtcctgcac tcgaacccaa tggactacgc ctggggggcc
      661 aacggcctgg acgccatcat cacgcagctc ctcaatcagt ttgagaacac cggcccccca
      721 cctgcagaca aggagaagat tcaggctctc cccacggtcc cagtcacaga ggagcacgtg
      781 ggctcagggc tggagtgccc agtgtgcaaa gaagactacg cgctgggtga gagagtgcgg
      841 cagttaccct gcaaccacct gttccacgac agctgcatcg tgccctggct ggagcagcat
      901 gacagctgcc cggtctgccg caagagcctc actggacaga acacagccac caatcctcca
      961 ggcctgaccg gtgttggctt ctcctcgtcc tcgtcctcat cctcgtccag ctcacccagc
     1021 aacgagaacg ccacaagcaa ctcctgagtc ccacctggcc atccccccgg ggcttggtca
     1081 tcccacccac cccaggtgcc ccagcaccgc ctgccatggc cgtggactag aggtgctgcc
     1141 catggcggcc ggcagcacct ggcgggcccc aggctgcggg cggctcggac ttggccatgg
     1201 ccgctcctgt ttggaggtgt gcacgtgggt cccatgtccc cagcaggcag gcgccttcag
     1261 tccgtcttta acctcaccct ccaaatgttc aacggcagaa gggtttttat gattttaaat
     1321 tattactgct ttgaaataaa tggacgtttg agccacgtgc ggccatgcat gatctgtgga
     1381 gagtcagcag aactgtcgcc aggcccagcc cgccacatgc cctgggaggc cgggccagca
     1441 cccagtcagc gccggcctcg ggaccacgag ggtgaccagc agacccagga acaaactgct
     1501 ccagcagaca tttttttttt tttttttaag ggaaatgtgt gttatctgga aagctattta
     1561 aaatacacct actcaaaaag caga
//
LOCUS       NM_001437948            7498 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 6, mRNA.
ACCESSION   NM_001437948 XM_063274028
VERSION     NM_001437948.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7498)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7498)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7498)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7498)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7498)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063274028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.41138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000015.1  105199266-105199522 c
            258-374             JAXUCZ010000015.1  105182942-105183058 c
            375-464             JAXUCZ010000015.1  105168842-105168931 c
            465-547             JAXUCZ010000015.1  105162379-105162461 c
            548-617             JAXUCZ010000015.1  105160417-105160486 c
            618-713             JAXUCZ010000015.1  105158803-105158898 c
            714-848             JAXUCZ010000015.1  105157736-105157870 c
            849-1023            JAXUCZ010000015.1  105151440-105151614 c
            1024-1091           JAXUCZ010000015.1  105149491-105149558 c
            1092-1166           JAXUCZ010000015.1  105137132-105137206 c
            1167-1307           JAXUCZ010000015.1  105135597-105135737 c
            1308-1505           JAXUCZ010000015.1  105134347-105134544 c
            1506-1628           JAXUCZ010000015.1  105133869-105133991 c
            1629-1711           JAXUCZ010000015.1  105129765-105129847 c
            1712-1834           JAXUCZ010000015.1  105129126-105129248 c
            1835-1914           JAXUCZ010000015.1  105124162-105124241 c
            1915-2102           JAXUCZ010000015.1  105123885-105124072 c
            2103-2168           JAXUCZ010000015.1  105123662-105123727 c
            2169-2261           JAXUCZ010000015.1  105122343-105122435 c
            2262-2385           JAXUCZ010000015.1  105120141-105120264 c
            2386-2507           JAXUCZ010000015.1  105119666-105119787 c
            2508-2594           JAXUCZ010000015.1  105118736-105118822 c
            2595-2684           JAXUCZ010000015.1  105117931-105118020 c
            2685-2800           JAXUCZ010000015.1  105115724-105115839 c
            2801-2870           JAXUCZ010000015.1  105113993-105114062 c
            2871-2996           JAXUCZ010000015.1  105113031-105113156 c
            2997-3068           JAXUCZ010000015.1  105111200-105111271 c
            3069-3215           JAXUCZ010000015.1  105101578-105101724 c
            3216-3299           JAXUCZ010000015.1  105101310-105101393 c
            3300-3411           JAXUCZ010000015.1  105100567-105100678 c
            3412-3590           JAXUCZ010000015.1  105098660-105098838 c
            3591-3704           JAXUCZ010000015.1  105098365-105098478 c
            3705-3822           JAXUCZ010000015.1  105096851-105096968 c
            3823-3956           JAXUCZ010000015.1  105091621-105091754 c
            3957-4068           JAXUCZ010000015.1  105089536-105089647 c
            4069-4135           JAXUCZ010000015.1  105087183-105087249 c
            4136-4183           JAXUCZ010000015.1  105085955-105086002 c
            4184-4227           JAXUCZ010000015.1  105082924-105082967 c
            4228-4343           JAXUCZ010000015.1  105076918-105077033 c
            4344-4481           JAXUCZ010000015.1  105074536-105074673 c
            4482-4664           JAXUCZ010000015.1  105074236-105074418 c
            4665-4778           JAXUCZ010000015.1  105072671-105072784 c
            4779-4994           JAXUCZ010000015.1  105072316-105072531 c
            4995-5052           JAXUCZ010000015.1  105069893-105069950 c
            5053-5159           JAXUCZ010000015.1  105067917-105068023 c
            5160-5282           JAXUCZ010000015.1  105053003-105053125 c
            5283-5396           JAXUCZ010000015.1  105051698-105051811 c
            5397-5543           JAXUCZ010000015.1  105050156-105050302 c
            5544-5754           JAXUCZ010000015.1  105046980-105047190 c
            5755-5945           JAXUCZ010000015.1  105035414-105035604 c
            5946-6046           JAXUCZ010000015.1  105031777-105031877 c
            6047-6185           JAXUCZ010000015.1  105031234-105031372 c
            6186-7498           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7498
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..257
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="upstream in-frame stop codon"
     CDS             138..6308
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 6 is encoded by transcript variant 6;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 6"
                     /protein_id="NP_001424877.1"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MQADKYRTSGRNDKKELVIESPLQYKDAAQADSEAENSALAKPK
                     LIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEEEA
                     QSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADKDE
                     DAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEK
                     ISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKI
                     LQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVK
                     LFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVE
                     PFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQAA
                     MQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQ
                     ACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADFRK
                     PEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCI
                     PKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGR
                     PGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGST
                     KKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEVKW
                     VEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEG
                     HVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAY
                     KAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE
                     NNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFT
                     FMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQ
                     RYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDD
                     RYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGNPL
                     MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPD
                     RNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKA
                     STAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVAHQSLL
                     EANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALK
                     NVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNN
                     FDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFS
                     SDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARI
                     HVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQ
                     DVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHR
                     AYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKL
                     YSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCHNI
                     RRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVA
                     IDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYP
                     DNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQ
                     ICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    4929..6173
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    4929..6173
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5241..5243,5271..5273,5277..5282,5286..5291,
                     5298..5303,5307..5312,5319..5324)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5241..5243,5271..5273,5277..5282,5286..5291,
                     5298..5303,5307..5312,5319..5324)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5343..5354,5358..5360,5445..5450,5454..5465,
                     5469..5474,5529..5537,5586..5588,5592..5594,5679..5681,
                     5685..5687,5706..5711,5727..5729,5844..5849,5856..5858,
                     5898..5900,5904..5906,5916..5918,5925..5933,5940..5951,
                     5955..5960,5967..5969,6051..6053,6105..6110,6114..6119,
                     6126..6128)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5343..5354,5358..5360,5445..5450,5454..5465,
                     5469..5474,5529..5537,5586..5588,5592..5594,5679..5681,
                     5685..5687,5706..5711,5727..5729,5844..5849,5856..5858,
                     5898..5900,5904..5906,5916..5918,5925..5933,5940..5951,
                     5955..5960,5967..5969,6051..6053,6105..6110,6114..6119,
                     6126..6128)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    5940..5957
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    5940..5957
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            258..374
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            375..464
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..547
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            618..713
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1091
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1505
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1628
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1834
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1914
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2102
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2385
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2507
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2800
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2870
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3215
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3299
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3411
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3590
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3704
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3822
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3956
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4135
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4183
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4227
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4343
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4481
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4664
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4778
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4779..4994
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5052
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5159
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5282
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5283..5396
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5543
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5754
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5755..5945
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5946..6046
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6047..6185
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6186..7498
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccaccc ctgaggctcc gcacttccag ccttgtgcct gggaaacagg cttccttgcc
       61 tttctctggc cagtggtgca gcaggggact ctcagctgtc cctgctgcag gctttctgac
      121 agtggtctgg gtggagaatg caggctgata agtacaggac tagcggtaga aatgacaaga
      181 aggagctggt catcgagtct cccctgcagt acaaggatgc agctcaggca gactcggagg
      241 cagagaactc ggcattggca aagccaaagc tgattgagcc acttgactac gaaaatgtca
      301 tcgtgcagaa gaagacccag atcctgaatg actgtctgcg ggagatgctc ctcttccctt
      361 acgatgactt ccagacggcc atcctgaggc ggcaggggcg ctacgtacgt tccacggtcc
      421 ctgcaaatgc agaggaggaa gcacagagcc tgtttgtcac cgagtgcatc aaaacctaca
      481 actctgactg gcaccttgtg acctatcact atgaagatta ctcaggagag ttccgacagc
      541 ttccaaacaa agtggccaag ttggataaac ttccagttca cgtctatgaa gtcgatgagg
      601 aggctgacaa agatgaggac gctgcttccc ttgggtctca gaagggtgga atcacaaagc
      661 acggctggct gtacaaaggc aacatgaaca gtgccatcag cgtgaccatg aggtcattca
      721 agaggcggtt tttccacctg attcagcttg gcgatggatc ctataatcta aacttttata
      781 aagatgagaa gatctccaag gagccgaaag ggtccatatt cctggattcc tgcatgggcg
      841 tgatccagaa caacagagtc aggcgcttcg cctttgagct caagatgcag gacaaaagca
      901 gttaccttct ggctgcggac agtgaggcag agatggagga gtgggtcaca gtcctcaaca
      961 agatcctcca gctcaacttt gaggctgcaa tgcaagagaa gcgaaatggg gaccctcatg
     1021 aagatgatga acaaagcaaa ctggaaggtt ccggttccgg tttggacagc tacctgcctg
     1081 aacttgccaa gagcaccaga gaagcagaaa tcaaactgaa aagcgagagc agagtgaagc
     1141 tcttttactt ggacccagat acccagaaac tcgacttctc atctgctgaa ccagaagtga
     1201 agccatttga agaaaagttt gggaagagga ttctcgtcaa gtgcaatgat ttgtccttca
     1261 acctgcagtg ctgtgtcgca gagaacgagg aaggacccac gacaaatgtg gagcctttct
     1321 ttgtcaccct gtccctgttc gacataaaat acaaccggaa gatttctgct gacttccacg
     1381 tggacctgaa ccacttctca gtgcggcaga tgctggcccc tgcatcccca gtgctgatga
     1441 acggtggtca gagtccacct gccttccagg atgcccttca ggcggccatg cagtatccga
     1501 agcagggaat attttcagtc acgtgtcctc acccagacat atttcttgtg gccagaattg
     1561 aaaaggtcct ccaaggaagc atcacgcact gtgctgagcc ttacatgaaa agctcagact
     1621 cttctaaggt cgctcagaag gtgctgaaga atgccaagca ggcatgtcaa agactaggac
     1681 agtaccgaat gccgtttgct tgggcagcaa ggacgttgtt taaagacaca tctggaaacc
     1741 tggataaaaa tgccaggttt tctgccatct accggcaaga cagcaataag ctctcaaatg
     1801 aggacatgct caagctgctc gcagacttcc ggaaacctga gaagatggcc aaactcccag
     1861 tgattttagg caatctagac attacaatcg acaacgtttc ctgcgacttc cctaattacc
     1921 tgaattcatc atacattccc atgaggcagt ttgaaacctg cagtaagtct ccgatcacct
     1981 tcgaagtaga ggagtttgtg ccctgcatac ccaagcacac ccagccttat acagtctaca
     2041 gcaatcacct ttatgtttac cccaagtact tgagatacga cagccagaag tcttttgcca
     2101 aggccagaaa cattgcaatc tgcattgagt tcaaggattc cgatgaagaa gactcgcaac
     2161 ccttgaagtg catttacggc agacctggtg gcccagtgtt cacaaggagt gccctcgctg
     2221 cagtcctaca ccatcaacaa agcccagaat tctacgatga gatcaagata gagctgcccg
     2281 cccagctgca cgagaagcac catttactgt tcaccttctt ccacgtcagc tgcgacaact
     2341 cgaccaaagg gagcacgaag aagaaggacg ctgtggagac acaggttggc ttctcctggc
     2401 ttcctctcct gaaagacggc agagtgttga cgaatgaaca gcatatccct gtctccgcca
     2461 acctgccgtc tggctacctt ggctaccagg agctcagcat gggcaggcat tatggtccag
     2521 aagttaagtg ggtggaagga ggcaagccat tgttgaaaat ctccactcat ctggtttcca
     2581 ccgtgtacac tcaggatcag cacttacaca attttttcca atactgtcag aaaacggaat
     2641 ctggagccca agcctcaggg agtgaactag tgaaatacct taagagtctg catgcaatgg
     2701 aaggtcacgt gatgatcgcc ttcctgccga ccattttaaa ccagctattc cgagtcctca
     2761 ccagagccac ccaggaggag gttgcagtta atgtgactcg ggtcattatt catgtggttg
     2821 cccagtgcca tgaggaagga ttggagagcc acttgaggtc atatgttaag tttgcctaca
     2881 aggctgagcc gtatatagca tccgagtata agacagtgca cgaggaactg acgaaatcca
     2941 tgaccaccat tctcaagcct tctgctgatt tccttaccag caacaaactt ctgaagtact
     3001 cttggttttt ctttgatgtg ctgataaagt ccatggctca gcatttgatt gaaaataaca
     3061 aagtgaagtt acttcgaaac cagagatttc cggcctccta ccatcacgcc gtggaaaccg
     3121 tggtgaacat gctgatgccg cacatcacac agaagtttcg agataaccca gaagcatcta
     3181 agaatgccaa tcacagcctg gccgtgttca tcaagagatg cttcaccttc atggacagag
     3241 gcttcgtctt caaacagatc aacaactaca tcagttgctt tgctcctgga gaccccaaga
     3301 ctctctttga gtacaagttt gagtttctcc gtgtggtgtg caaccatgaa cactatattc
     3361 ctttgaactt gccgatgcca tttgggaaag gaagaattca gagataccaa gatctccagc
     3421 ttgactactc tttaacggac gaattctgca gaaaccactt cttggtggga ctgttactaa
     3481 gggaggtggg tactgcactc caggagttcc gggaggtccg tgtcatcgct gtcagtgtgc
     3541 tcaagaacct tctgatcaag cattcttttg atgacagata cacttcaagg agtcaccagg
     3601 caaggatagc caccctctac ctgcctctgt ttggtctgct tattgaaaac gtccagcgga
     3661 tcaacgtgag ggatgtgtcg cccttccctg tgaacccggg cagtatctcg aaggacgaag
     3721 ccctggccgt gcctaccggg aatccactca tgactccgca gaagggaaac acacttgacc
     3781 acagcctgca caaagacctc ttgggtgcca tctccggcat tgcttctccg tatacagctt
     3841 caacccccaa catcaacagt gtgagaaatg ccgactcaag gggctctctc atcagcacgg
     3901 actcggggaa cagccttcca gacaggaacc ccgagaagag caactccctg gacaagcagc
     3961 agagcggcat gctgggaaat tctgtggtcc gctgtgacaa actggaccag tctgagatca
     4021 agagcctgct gatgtgcttc ctctacgtgt tgaagagcat gtctgacgat gccctgttta
     4081 cgtactggaa caaggcttcc actgctgaac tgatggattt ctttaccata tctgaagtgt
     4141 gcctgcacca gttccagtac atggggaagc gctacatagc cagtgtgaga aagatatcaa
     4201 gtgtgcttgg gatttctgta gacaatggct acggccactc ggaggcagat gtcgctcacc
     4261 agtcgcttct cgaagcaaac atcgccactg aggtctgcct cacagctctg gacaccctct
     4321 cgctgttcac actggctttt aagaaccagc tcctagctga ccatggacat aatccactca
     4381 tgaagaaagt ttttgatgtc tacctgtgtt tcctccaaaa gcatcagtca gaaatggctt
     4441 taaaaaatgt cttcactgcc ttaaggtcat taatttataa gttcccctca acgttctacg
     4501 aggggcgggc agacatgtgc gcatctctgt gctatgaggt tctcaagtgc tgtaactcca
     4561 agctcagctc catccgcacc gaggcctccc agctgctcta cttcctgatg aggaacaact
     4621 tcgactacac agggaagaag tcttttgtcc ggacacactt acaggtcatc atctctgtca
     4681 gccagctgat cgcagacgtg gttggcattg gaggaaccag attccagcag tccttgtcta
     4741 tcatcaacaa ctgtgccaat agcgaccggc tcattaagca caccagcttc tcctctgatg
     4801 tgaaggattt gaccaagagg atccgcacag tcctgatggc cacagcccag atgaaggaac
     4861 atgagaacga cccagagatg ctggtggacc tgcagtacag cctggccaag tcctacgcca
     4921 gcacccctga gctcaggaag acatggctgg acagcatggc aaggatccat gttaaaaatg
     4981 gggatctctc agaggcagca atgtgctatg tccacgtgac agctttggta gcggaatatc
     5041 tcacacggaa aggcatgttc agacaggggt gcacagcctt cagggtcatc acaccaaaca
     5101 ttgatgaaga ggcttccatg atggaagatg tcggcatgca ggatgtccat ttcaatgagg
     5161 atgtgctgat ggagctgctg gagcagtgcg cagatggact ttggaaggca gagcgctacg
     5221 agctgattgc tgacatctat aaactcatca tccccatcta tgaaaagcgg agggactttg
     5281 agagactagc ccacctgtat gacacgctgc accgcgcata cagcaaagtg acagaggtca
     5341 tgcactcggg ccgcaggctc ctggggacct acttccgggt ggccttcttc ggacagggat
     5401 tcttcgaaga tgaagacggg aaggaataca tctacaaaga gcccaaactc acgcctctgt
     5461 cagagatttc tcagagactc cttaaacttt actcggataa attcggttct gaaaatgtca
     5521 aaatgataca ggattctggc aaggtcaacc cgaaggatct ggattccaag tttgcttaca
     5581 tccaggtgac ccatgtgacc ccgttctttg atgaaaagga gttacaggag aggaaaacag
     5641 agtttgaacg atgtcacaac atccggcgct tcatgttcga gatgcccttc acccagactg
     5701 ggaagaggca gggtggcgtg gaggagcagt gtaagcgacg gaccatcctg acagcaatac
     5761 actgcttccc ctatgtaaag aagcggatcc ctgtcatgta ccagcaccac actgacctga
     5821 accccattga ggtggccatc gatgaaatga gcaagaaagt ggccgagctc cgccagctgt
     5881 gttcctcagc tgaagtggac atgatcaaac tgcagctcaa actgcagggc agtgtgagcg
     5941 tccaggtcaa tgctggcccg ctagcatacg cccgagcctt cctcgatgac accaacacaa
     6001 agagataccc tgacaataag gtgaagctgc tgaaggaagt tttcaggcaa ttcgtggaag
     6061 cttgtggcca agccttggca gtgaacgaac gtctgattaa agaggaccag ctggagtacc
     6121 aggaagagat gaaagccaac tacagggaga tggccaagga gctctccgac atcatgcgtg
     6181 agcaaatttg ccccctggag gagaagacaa gcgtgctacc aaattccctg cacatcttca
     6241 acgccatcag tgggacacca acaagcacag tggttcaagg gttgaccagt tcatcctcag
     6301 ttgtgtgact ttacctcatg aaccacacgt ggggacatgc tttgtcatgt gcaaactcag
     6361 gacgactttc agagctaatc actggttttg ccaagcacag gaagaagcca tggggaatgg
     6421 gagagagaaa gagcctggac tgtgatattt aatagcagat tttataggag ttgggggaag
     6481 gtgcacatat ttttttaaat atcactggca atgtttagtt ttcctcatgt cttaacaggt
     6541 gtatgtggat actcttgggc tgcagttcaa ttttattctt cttacagtat agtattaaaa
     6601 taaatggtct aaaggaaaag agggaaagta tgctgggaca cctgtagcag gtgtgctggg
     6661 acacctgtac cagctgtgct gggacacctg taccagctgt gctgggacac ctgtagcaga
     6721 tgcagcagca ctgaacctgg gaatggggac taagctggaa aaatcttgaa aatatttttc
     6781 tccctgtggc acattcaggt tgagtacaag aactattttt gtgtctagtt ttgaagactg
     6841 aagggaattg actattgaga ttttttacta gtgaatgcgg agacttagag cctttatatc
     6901 catgccttgt gttgacaaca tgagcacttc cgaagctgag tgtgatgtga gcctaagcct
     6961 agtcagcagc atagaaccaa aggcctgcac tagcgaacac acctatgcta aaacctaaaa
     7021 ccccatgtac atatgttctg ttaatacggc ctcctcgctg agtccacgta cttactacat
     7081 ttctacactt ttaatacatc agtgtccgtg ttaagtttat tattcgtgac ccatttgtgc
     7141 tgttctcggt atatgcaaat acattggact tcactgttta ttcttgtaca taagaagtgc
     7201 aatatggaga tgtatacagt ctttgctatg ttaggtttat aaactgtttt taaaaagaaa
     7261 ttcatccttt tgccaaaatg gtggagtatg tgattggtaa accctaaacc ctgtggtgag
     7321 tggagggata atttaaagtt ttcaccatgt tatattttct tttaagactt taatttagta
     7381 attttatatt tgggaaaata aaggttttta atttaactgg aatcactgcc ctgctgtaat
     7441 tacatatcgt gtaccccaac tgtattaaaa ataacactgc tgattttctg gtaataaa
//
LOCUS       NM_001437955            2443 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus AT-rich interaction domain 3A (Arid3a),
            transcript variant 4, mRNA.
ACCESSION   NM_001437955 XM_006240902
VERSION     NM_001437955.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Tidwell,J.A., Schmidt,C., Heaton,P., Wilson,V. and Tucker,P.W.
  TITLE     Characterization of a new ARID family transcription factor
            (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated
            immunoglobulin gene transcription
  JOURNAL   Mol Immunol 49 (1-2), 260-272 (2011)
   PUBMED   21955986
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Nixon,J.C., Rajaiya,J. and Webb,C.F.
  TITLE     Mutations in the DNA-binding domain of the transcription factor
            Bright act as dominant negative proteins and interfere with
            immunoglobulin transactivation
  JOURNAL   J Biol Chem 279 (50), 52465-52472 (2004)
   PUBMED   15456761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006240902.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2414196.1,
                                           SRR26643293.38640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000007.1  10427842-10427986   c
            146-778             JAXUCZ010000007.1  10427109-10427741   c
            779-1094            JAXUCZ010000007.1  10426019-10426334   c
            1095-1167           JAXUCZ010000007.1  10411872-10411944   c
            1168-1351           JAXUCZ010000007.1  10409498-10409681   c
            1352-1599           JAXUCZ010000007.1  10408421-10408668   c
            1600-1896           JAXUCZ010000007.1  10407232-10407528   c
            1897-1995           JAXUCZ010000007.1  10406751-10406849   c
            1996-2443           JAXUCZ010000007.1  10405925-10406372   c
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2443
                     /gene="Arid3a"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
     exon            1..145
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            146..778
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    165..167
                     /gene="Arid3a"
                     /note="upstream in-frame stop codon"
     CDS             408..2192
                     /gene="Arid3a"
                     /note="dead ringer homolog 1; AT rich interactive domain
                     3A (Bright like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     3A"
                     /protein_id="NP_001424884.1"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
                     /translation="MKLQAVMETLIQRQQRARQELEARQPPLPPPPEPAGVQARTTMT
                     DEDREPENARMHRTQMAALAAMRAAAAGLRHPSSPGGSEDEDTAQGGTLSSPALHGSG
                     QEGPGHTEGDGHLMDMGSDDDTKPKWEEQELEELGEEEEEEDEDDFEEEEEDEEEEGL
                     GLPESASLGSAGLFTRKAPPTQTFRGDGGPRMLSGPERLGPGPAHPSHVASQMPPPDH
                     GDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVL
                     VTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPN
                     ELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLSSPKLPVTSLGLAASTNGSSITPT
                     PKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREK
                     LESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDPAVNL
                     TSANGSNSISMSVEMNGIVYTGVLFAQPPPPTPPPASSKGGVSSIGTNNTMGNRTGAS
                     GSAGSSGQVGLAGVSAPTMSSTSNNSLP"
     misc_feature    1056..1454
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    1056..1454
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    order(1182..1202,1275..1277,1281..1286,1293..1295,
                     1317..1328,1332..1340,1344..1346,1434..1439)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     misc_feature    order(1182..1202,1275..1277,1281..1286,1293..1295,
                     1317..1328,1332..1340,1344..1346,1434..1439)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     exon            779..1094
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1167
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1351
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1599
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1896
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1995
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2443
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcttctt atgggacaat aaccccatgg tgtctctggt ggacctgccc agaggggacc
       61 cagagattcc cttggtgtcc actgcagtga ccctggtcct gaggaacctg cagacaggca
      121 gatgagggta tgaacccctg agcaggagtc tgcaggtgct tgaatgagcc cgacaccagc
      181 ctctgcccct gggtgcccga cgtaacaaca aggatcccac tggtcgcccc tggcatgccc
      241 caccagcctt caccctgagt tggcagcccc cacccctgcc agccgtcacc ctgcattgtt
      301 ccggctcccc cgaagtcccc acgctgcagt gcggccaaga cccctcccca cgggggccac
      361 ccccaccaag tgcccctggt gcccggggtg gcccggcccg tcgggccatg aagctgcagg
      421 cagtgatgga gactcttatt cagaggcaac agcgagcccg gcaggaactg gaggctcgac
      481 agcctccact acccccacca ccggagcccg ctggtgtcca ggctcggacc accatgacag
      541 atgaggacag ggagcctgag aatgcccgta tgcataggac gcagatggct gcactggctg
      601 ccatgcgggc tgctgccgcc ggcttgagac atccgtcctc tcccgggggc tcggaggacg
      661 aagacacagc ccagggaggg actctgagtt cacctgccct gcatggaagt ggccaggagg
      721 gaccgggaca cactgaggga gacggccatt tgatggacat gggctccgat gatgacacga
      781 agcccaagtg ggaagaacaa gagctggaag aactggggga agaggaagag gaggaggatg
      841 aagatgactt tgaggaagaa gaggaggatg aggaggaaga aggcctgggc ctcccagagt
      901 ctgccagcct gggctccgca ggcctgttta cccgcaaggc cccacctact cagaccttcc
      961 gtggagacgg tggtcccaga atgctcagtg gccctgagcg cctgggacct ggcccggccc
     1021 accccagtca tgtggcgtcc cagatgccac caccggacca tggggactgg acatttgagg
     1081 agcagttcaa acagctctat gaactggacg cagaccccaa gaggaaagag ttcctggacg
     1141 acctgttcag cttcatgcag aagcggggca ctccggtgaa ccggatcccc atcatggcca
     1201 agcaggtcct cgacctgttc atgctgtatg tgctggtgac ggaaaagggc ggtctggtag
     1261 aggttatcaa caagaagctg tggagggaga tcaccaaggg gctcaacctg cccacctcca
     1321 tcaccagtgc tgccttcaca cttcggacac agtacatgaa gtatctttac ccctatgagt
     1381 gtgagaggcg aggcctgagc agccccaatg agctccaggc tgccatagac agcaaccgcc
     1441 gggagggcag gcgccagagc ttcgggggct ccctctttgc ttactcaccc agtggagccc
     1501 acagcatgct gtcctcaccc aagctaccgg tgacttcttt gggccttgct gccagcacca
     1561 atggcagctc tatcacccca acacccaaga tcaagaaaga ggaagactca gccatcccca
     1621 tcacagtccc aggccgccta cccgtgtctc tggcaggcca ccctgtcgta gcagcccagg
     1681 cagcggctgt gcaagccgca gcagcccagg ctgcagttgc ggcccaggca gccgccctgg
     1741 aacaactccg ggagaagctg gaatccacgg agcctccgga aaagaagatg gccctggttg
     1801 cagatgagca gcagcgtctc atgcagcgag ccgtgcagca gagcttcctg gccatgacag
     1861 cccagctgcc catgaacatc cggatcaaca gccaagcctc tgagagtcgc caggacccag
     1921 ctgtaaatct caccagtgcc aatggcagca acagtattag catgtccgtg gagatgaacg
     1981 gtattgtata cacaggggtg ctgttcgctc agccaccacc tcctacgcca cctcccgcct
     2041 ccagcaaagg tggtgtgagc agcattggta ccaacaacac catgggtaac cggacaggag
     2101 ccagtggcag tgctggcagc agcggccaag tggggctggc tggggtgtct gcacccacca
     2161 tgtcttctac ctcaaataac tccttgcctt aaaaggaaac caagttgcat ggctgcccac
     2221 ccgccacagg aaccacatgg ccacacaggg ggacctggga cgtcagaaga atcccagtgg
     2281 gctgggcaga ttcccaagga gccacactga cgccaaaaag gagagagaga gatagagaga
     2341 gaaagagaga gagagaaaat atatatatat acatatatat atatacatat agaaagagat
     2401 aggtagatgg agaaacagat ctaataaatc agggcaaagc aaa
//
LOCUS       NM_001437932            9193 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 3, mRNA.
ACCESSION   NM_001437932 XM_039078944
VERSION     NM_001437932.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9193)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9193)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 9193)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 9193)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 9193)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 9193)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 9193)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 9193)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 9193)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 9193)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078944.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.43640.1,
                                           SRR26360181.1424345.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               JAXUCZ010000007.1  136254218-136254570 c
            354-536             JAXUCZ010000007.1  136227163-136227345 c
            537-723             JAXUCZ010000007.1  136218085-136218271 c
            724-824             JAXUCZ010000007.1  136213218-136213318 c
            825-9193            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..9193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..9193
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..353
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            354..536
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    376..378
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             400..975
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424861.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    454..603
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    454..603
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(454..465,514..516,520..522,553..555,565..585)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(454..465,514..516,520..522,553..555,565..585)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    745..918
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    745..918
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(772..774,778..792,814..816,841..843,901..903,
                     910..915)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(772..774,778..792,814..816,841..843,901..903,
                     910..915)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(784..786,898..906,910..915)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(784..786,898..906,910..915)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(868..870,880..885,889..894,901..906)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(868..870,880..885,889..894,901..906)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            537..723
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..824
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            825..9193
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggactcga gttgcacgcg gcgcatgcgt cctgttactt catacgcagg cgcaacaaaa
       61 gacacaggtt ggtctggtcc atcgccatta agacttagta tctctttaac aagagatcat
      121 tagaccagat agggaaaaac gaaaaaaagg ccacaaaccc cagatcgtta agtgtaagaa
      181 ttctgccaaa aggaacagtg cgtagaaact aatggctgtc ggatcgcagc ctcatggtga
      241 ctatgaggac aaaatggcga cctgcatttt ttaaagtagg cctcagcagt aatcgatcaa
      301 acaccgaaag cacgggagcc agcgacaaaa caggtcacat cccgtcatat tcagaacctg
      361 gtggccgcac tcctttaggt ggaccaacac atacccaaca tgggaaagaa gaccaagagg
      421 acagccgaca gctcttcatc agaggatgag gaggagtatg tggtggaaaa ggtgttggac
      481 aggcgcatgg ttaaagggca agtggagtat ctgctgaagt ggaaaggctt ttctgaggag
      541 cacaacactt gggaacctga gaagaacttg gattgtcctg aactaatttc tgagtttatg
      601 aaaaagtaca agaagatgaa ggagggagag aacaacaagc ctagggagaa gtcagaagga
      661 aacaagagga aatccagttt ttccaacagt gctgatgata ttaaatccaa aaaaaagaga
      721 gagcaaagca atgatatcgc tcggggcttt gagagaggac tggaaccaga aaagatcatt
      781 ggggcgacag attcctgtgg agacttaatg ttcttaatga aatggaaaga cacagatgaa
      841 gctgacctgg tccttgcaaa agaagctaat gtgaaatgtc cacaaattgt gatagcattt
      901 tatgaagaga gactgacgtg gcatgcgtat ccagaggatg cggaaaacaa agaaaaagaa
      961 agcgcaaaga gctaaaggag gaggcagtct ctgtcatttc tctttgtata taataccttc
     1021 accttcctgc ctcctctcgc ttctcccgtc cctttccatc ctaaacatat ccataaaaat
     1081 gatgtgctta tcaatcactg tgctccacgg gagagatgtt ggtattggtt cccttgtaat
     1141 ataactgatg gtctgactcc taagtgtagc tctgtgaaag tcaggcatta catccttcac
     1201 atgctgtgtg gttcccatag tgttctcttt catcctgatc ttttccttct gttccctgta
     1261 acttttaatc accttagagt cgtgatcttt ggggttggtt gctttgggga attttattat
     1321 aatgacgatg acttcagttt cttggttgtt aattagaata tattgatgac cagctggcct
     1381 ttgttttgac atactggcat agaaaggatg ttgtccagct tttagaaagc taatagcagc
     1441 agcctacatg ttgtgtattt tttaatctca cttagctctg ccaggagaat acagggtccc
     1501 tggtgtggtc ttctgggcca ctcctgacta ttctcaccta ccctcccata acaactcagt
     1561 tctcttgagg gcttgagact ttacactgtt tagccctcac actcttttgg cttcgttact
     1621 ttcaatccct gattctgctt ctgtaaagtg tatcagtttg ttattaaatg acaggattaa
     1681 ctgtggggtc tgtaagctgt agtgcaggac gataacagga cggggctgga tgcggttgtc
     1741 tttggtatca catggtgtgc atgtgttctt tccttcaccc tcattcctag actctattta
     1801 tgtaggtgta gggactgcct ggtgcttgct tgtgccaagc accctgccaa cttttatggc
     1861 ctcccaaagc attcctgtac caaagaggaa tcagcagatc cacacattcc cttccgtgcc
     1921 gttattttaa gttgggaatt gttagaaagg aaccattagc cacagtgtca tcagtttcta
     1981 aatcctcaca gcagtgatag atactcttta actttaccac taagtcccta gaggattaat
     2041 gttcctgccc tctccatcct cagactttta gttgtagctt attttaaaaa ctattttcat
     2101 ggaagaccat cgcctcagaa accaacaggt cttgacatta gctttttgac acaaccttct
     2161 cccacaacaa actactcctt tttgatttac tcttactttg ctattatttc tgctcctgtt
     2221 ctgttctttt tgtcccctga aaatgtccat cttctcttca ttcctttctt cttatatagt
     2281 tgaggagact gagaatcagg actaaatgta aggaaataac agggtttgga gctgagcact
     2341 cttttttttt tttttccccc ccccccggag ctggggaccg aacccagggc cttgcgcttc
     2401 ctaggtaagc gctctaccac tgagctaaat ccccagcccc aggagctgag cactcttgac
     2461 ccagctcaaa agctgaggaa aaggagtaaa cgctgagata gccttaattc tagactttat
     2521 caactactga ggctgttttt gttgttcctt tcggttttta aagcatagct atctgagcag
     2581 ccacccattt ctagatcgtt catggtaatg aggggaagga gtggagtgct ctggtccaca
     2641 gatgacccaa gtgtgtgcac gtcctagacc cattcagtgt ttgctagcat cacttctctg
     2701 ctcagctgcc actgagctct gtgttcttga ataaattatg tcaacaatta tactgcacag
     2761 ttgacaggac agccaggaag aacctgtgaa tggtactgtg gtaggggaag agcacctaac
     2821 ccttacctct ccgtagttca ttctctgaag atggtagagg caagctcaaa ggctggataa
     2881 gtgaccattg tctgcttaac ttgatgaaat gcaggtggtt agagagcaga tgtgtccttc
     2941 acgcaaccta gactagtaat tagggcagat gaaggtagcc cagaagtggc ccagttcctg
     3001 aggatcttag tctctgatta gcagctggag ggaaggacag cctgctgagc actcagcagc
     3061 agtgggctgt aaactggcag tggaaggact gagtatacag tttgaggatt taatgccttg
     3121 taatgcaaaa aatgaaggga aggagtggcc tgctggtttt aatgctcttt acaatgtttt
     3181 tccctctcaa aagttcatgg agtattggtt ttctgttaat tattaccaaa actctcttgt
     3241 ccgtgtctcc cccccccccc ccccagctgg ggaccgaacc cagggccttg cgcttgctag
     3301 gcaagtgctc taccactgag ctaaatcccc aaccccttgt tttcctctta gtaagtttcc
     3361 tggttatata tagaaatagg gaaccgggat tccagtattc tcttcagctc tcagtatgaa
     3421 gaagccagac acccatttgt gcctccagcc tgtgttgtgc caagtagctt gattctgctg
     3481 gagaattgca gctgtggaca aaagtgtttc ctagagttat cttctatctt cgctctaaag
     3541 agttcatggc caaaggtgaa agaaatactc ctaaacactg actatattct cctgtgttaa
     3601 ccctctccag aactaatttt gtggtactgg aaattgaacc taggaccagc gtggacagcc
     3661 gggcaactgc tgtgccattt ttgtctgccc cctttcctcc cctgccatac agttgatgga
     3721 tcaccaaatt cacctgtttt tgttgctcta aggactttaa gtcactgata ccaagctaac
     3781 cttggttgta taaccaagtt gaattctttt tttttttttt ttaaacttat gtgactatgt
     3841 tgttgctgtc ttcagacaca ccagaagaag gcatcggatc acattacaga tggttgtgag
     3901 ccaccatgtg gttgctggga tttgaactca ggacctctgg aagagcagtc agtgctctta
     3961 accactgagc catcctccag ccctgctaag ttgaattctt tttttctttt tttctttttc
     4021 tttttctttt ttccgaagct ggggaccgaa cccagggcct tgcgcttgct aggcaagcgc
     4081 tctaccactg agctaaatcc ccaaccccct aagttgaatt cttgatctcc tgcctcttcc
     4141 cagtctctag gattataggt atgtgccacc atatctggct cttagctcct tctatatgga
     4201 gttatctgtg ctagccaggt acagtgtaat acacctttat ttccagtctt taggaggcag
     4261 aagtagataa atcttaatcg gaggcctgcc tggactatat agtgagttct aggccagcca
     4321 cacctacata gatcttgttg tgaaaggaaa aataggaaaa gagtacccag attggccttg
     4381 aacttaggat ctttatgtat cagttgtatg ccactatgcc tggctcaaaa tgcctttttt
     4441 tttctttatt aacttgagta tttcttattt acatttcgat tttttttaag ttatatatat
     4501 atgtgatttc tgcctgcatg tatatgcacc atatgcatgc ctggttccct aggagacaga
     4561 agagggtctc atatcctctt agataggagt gagccactat gtgggtgttg agaatcagat
     4621 ctggaagagt agtcagtgct cttaactgct gagccatctc ccacccttca aaacatcttt
     4681 ctaaagttga atttcttccc cccccccttt tctgtttagt cctgactgtt tcttgctggc
     4741 ttcaccctct agtgctcacg ttttgctagc tttgtgcaaa aacaggtgaa ctgggtgatc
     4801 catcctcaat tttacacatt gtgttgttca catttctaca actttagcat acatcaatat
     4861 tgttttcatt caacaaacag ttttggctca ggaactcgct agagaacttt gatagtggtg
     4921 tgggatgagt tgatcagtat agttttggat aatgaatact gcacatgtat ataaattact
     4981 ggtctgggac agcatcaggt atacaaaaag gtgagtcttt agtgggcagt tagttaagtg
     5041 gttgagtgct ggtgaggaat ccatgaagcc ctgggtttcc acgggggggg gggtaaggta
     5101 aatctgcagt aggagggggg ggtaaggtaa atctgcagta ggaggggggg gtaaggtaaa
     5161 tctgcagtag gagggtgcca ttaactgctt catctgtggg aaagactgtg gtcttggatg
     5221 aactgagtta actggccatg ggcagcattg caggaaataa agctagaaag gctttcgttt
     5281 cgttaccaag agtgcagatg aatgagcgtg agaactgtct tgtttagact gccaagcatt
     5341 catgactgtg ttagtattgc ctgtgctggt gtatatttct tctttgtggg cgttttagca
     5401 agttgctcac actgttcaat ttctcaccct tttggagaaa tcaacattag tctggcttta
     5461 aagcccaaaa cataccatct aatgacaaga cttccttaga acaaagctta ggaatgagct
     5521 acctttggat cacgtgggtc tcagtgccag ggagtaagca gctcctgtgt cacttatatc
     5581 aaaaccttcc acaggaataa tgtgctctgg ctcctcattg tgcgtgacac ccttctcaga
     5641 gaaggaaagg tctgtttttc aggttcttat tctgactcct gagagcccaa gacgaagatg
     5701 taattgactg actttagaag tcagaattcc cagaaattca actaactgct ctagaaggtt
     5761 aaaatgtgaa gtttcttgtt tgttttttgc ttgtgctgaa tattttgaat tttcatctac
     5821 ctcgtcttat ttttcttagt tacttctgtc attaccactt gagcatcaag cttgattttg
     5881 gtcattgtct aaaatggggt ctctcctgtt cagtgacagt ttattccctt gtctttcctc
     5941 ttggccctca tttcacctaa catcatctct tattgctcct gtcagaaata tgttttaaag
     6001 tcttgtttta tgggaaaaag tggtccacca atgctgtttg tctctgaggt cagtgagaga
     6061 aggagttaaa acacagtggt ggaggaaggg cagagcctgc ctgcactgga ggcaaaagct
     6121 gacaaggaag gagtcattaa ttaaagacaa tttcaaagtc aactgattgt gatcattaat
     6181 gtcacaatag atcaaaacct aattatcaca gcctaggtaa gagccatcag tattaatcgg
     6241 aaaatctaat aggaaactat tagcaagaaa ttaggccaaa ttgaatgcaa tgaacttttt
     6301 atcatctttt tttggtaatg ttcttggtgt tggcaactgt gaccctaaca gttggtccaa
     6361 gcccagattg ctaattttaa agagcctttt tttttttttt ttttaagtaa cccaggctga
     6421 ccctagtgct tacagccctc cagcttcagc cttgagcact gggattatga ggggtacatg
     6481 catttgtgtt tgtgtgggtg ggtaggagag aattgaactc agggccttgt acattttaga
     6541 caagtgctct accactgaac tgtattccta gctcagagtg ttttgtttgt tagggaagtt
     6601 tccagacaga ctgaacctaa gctgacattg ctgaaacacc agccttgaat ttttttatca
     6661 tatggatcta ttcattctaa tcagatcagc gggatataaa catatatatt aaagtcgtag
     6721 agtgtcccta gtgaacatca tatcatctgt tgagtgcttg tatatagagt tctatactgg
     6781 ttgttgtgaa ggctgtggga ggaaggcagt gtcctgcttt gaaattcttt gaaaactaaa
     6841 aagatagttt ccttgtgtga cagcatgatc aagatgcaag tctgtgtttt tcagtttcca
     6901 ttagcattag ggtttgatcc taaaccagct tagcagtgcc cccaacccca atagttttaa
     6961 gataggcaca aaatgatttc ctactggaat tctaaggtat ggggaagaca tctttgtttc
     7021 tgttttcctt tctggtagta ggagaagcat cagtatgtcc ttaagatgtt tgtaaagatg
     7081 ctaccccctt taggtgagat gagtcaggct gtggaacggt tgctgtcaca ggaggagtgc
     7141 caggcagtag tagagggaat tgtgcttagg agtctgcact gtgccctgca gccctcagat
     7201 gctcagtgct gaccttagga ggcccatgct gctttctgga ccttgggaac ctggattacc
     7261 cagtagaaga ctgagaatca atgtcttttg tttgtttgtt tattttttgt tctgtttttg
     7321 ttttgttttg ttttgttttc caagatgggg tctctgtgta gccatggatg tcctggaact
     7381 tgctctgttg accagactgg cctcgaactc aaagatctgc ctgcccctgc ctcccaagta
     7441 ctgtgatcaa acgtgtgcgc catcactgcc tggctaaccc ttcacttctt agtgagtttt
     7501 agtgtttaaa aaatgcaact taattttcaa agtggcacta aggtggtttg tccagccttg
     7561 ggttactcca ggtgagcagc agccctcaat taacagtgtg ttgattggac tcatccggct
     7621 gcagtgaaat gactgaaagt gagatgttct agtgcatagt tctgtgctaa cctcctactt
     7681 ggtcttaatg gctgaccttg ggcaagtctt tcctttcaat gcctcagttc cccatctgtc
     7741 aaatggggtg ataatactga cctacctcat ggggtgttgt gaggcattac agatcagagc
     7801 tgatcaaccc tttaggattg cctgtggagg ataccttaag tcggactctt ttagccctca
     7861 ctgagctact tccaagtttg gaagtagtta gtgaccttgg cgagtttctg tccccccacc
     7921 ctttacccct catcaaagct gctagttcag atgttaacag tgttttgtga atgttggagt
     7981 cttgatcgtc cagtctaact tgggacaatg taagggaagg cacttgtggg ttctgtgtct
     8041 tatattacaa agagactgtt agaaattcaa gagccttggt ttaggaatct tgaggcagga
     8101 atgctaccgc atgtctttct ctgcaggagt taaggtccta ttctcatgga cttataacta
     8161 cttctgactg tcttcgaaag gaagtgacac ttggtatttt ggatttatat tgttgctttc
     8221 attttccaga ctgatcctag gacagttagt ctactgaacc cttcatgctt ctatgcctct
     8281 gccctctcat agaagccaga tggttcaagc aacatagctc tcccttcccc caccaaaaag
     8341 ctgtattgga tttttgtttt tttgtttcta gaaataggtg taacatttca gaattgagca
     8401 ttggtcctca aggcttcttc cagttcactg tgtgtggaat ctgtcacctc ttttcagtgt
     8461 ccaccatctg acccactgag gacatcttgg acacttgttt gcccacttga gggttcaaaa
     8521 gccttactct gtgtttcagt atagggctaa ggcatcccca agctcttcgt gataggtttc
     8581 ctttccccta cttgaccttg tattggtacc atgaaaaagc acacagtcct agctccctgg
     8641 aggtacacac tccagtactg ttaggtggac tctactccta acagggatcc tagagggttc
     8701 tctggaggat gggaaaggag cagtctcatg tcctgccaag tagtagccag cagttgcctt
     8761 acccctgcct gctggccatg ttcccacctc ctcatggaga gggctttcag aggtcctcga
     8821 ggctggattt tctcagtctc tgctgtgcca ttctgagtgg gaagcagacc acactttgtg
     8881 gccaggtgtc taagtggaag tgaggtcttg aattctcggt ggactttttg gtttgtgggg
     8941 gagttttggt tgtgtttctt ggttctattt cagccaaact cgcctgcttt tgatttcttt
     9001 aaaggataag tggtctatct atctatatac atgtatgttt gcattttaag tgtaaatgtt
     9061 ttgaaaaaaa aaaacagaca tgtctttcta taactgacat ccgattcaga catcattctc
     9121 tccccttcca ccctcttttc cctcttttca tactcttgta ttggttctaa taaaggattg
     9181 cttttcaaat atg
//
LOCUS       NM_001437936            8888 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 8, mRNA.
ACCESSION   NM_001437936 XM_006242393
VERSION     NM_001437936.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8888)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8888)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 8888)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 8888)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 8888)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 8888)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8888)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8888)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 8888)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 8888)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006242393.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.969573.1,
                                           SRR26360176.1738214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000007.1  136229085-136229132 c
            49-231              JAXUCZ010000007.1  136227163-136227345 c
            232-418             JAXUCZ010000007.1  136218085-136218271 c
            419-519             JAXUCZ010000007.1  136213218-136213318 c
            520-8888            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..8888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..8888
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..48
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            49..231
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             95..670
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424865.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    149..298
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    149..298
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(149..160,209..211,215..217,248..250,260..280)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(149..160,209..211,215..217,248..250,260..280)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    440..613
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    440..613
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(467..469,473..487,509..511,536..538,596..598,
                     605..610)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(467..469,473..487,509..511,536..538,596..598,
                     605..610)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(479..481,593..601,605..610)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(479..481,593..601,605..610)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(563..565,575..580,584..589,596..601)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(563..565,575..580,584..589,596..601)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            232..418
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..519
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..8888
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccctcc tgttagccca gagggaaaga acgaactggg gcgatccgga acctggtggc
       61 cgcactcctt taggtggacc aacacatacc caacatggga aagaagacca agaggacagc
      121 cgacagctct tcatcagagg atgaggagga gtatgtggtg gaaaaggtgt tggacaggcg
      181 catggttaaa gggcaagtgg agtatctgct gaagtggaaa ggcttttctg aggagcacaa
      241 cacttgggaa cctgagaaga acttggattg tcctgaacta atttctgagt ttatgaaaaa
      301 gtacaagaag atgaaggagg gagagaacaa caagcctagg gagaagtcag aaggaaacaa
      361 gaggaaatcc agtttttcca acagtgctga tgatattaaa tccaaaaaaa agagagagca
      421 aagcaatgat atcgctcggg gctttgagag aggactggaa ccagaaaaga tcattggggc
      481 gacagattcc tgtggagact taatgttctt aatgaaatgg aaagacacag atgaagctga
      541 cctggtcctt gcaaaagaag ctaatgtgaa atgtccacaa attgtgatag cattttatga
      601 agagagactg acgtggcatg cgtatccaga ggatgcggaa aacaaagaaa aagaaagcgc
      661 aaagagctaa aggaggaggc agtctctgtc atttctcttt gtatataata ccttcacctt
      721 cctgcctcct ctcgcttctc ccgtcccttt ccatcctaaa catatccata aaaatgatgt
      781 gcttatcaat cactgtgctc cacgggagag atgttggtat tggttccctt gtaatataac
      841 tgatggtctg actcctaagt gtagctctgt gaaagtcagg cattacatcc ttcacatgct
      901 gtgtggttcc catagtgttc tctttcatcc tgatcttttc cttctgttcc ctgtaacttt
      961 taatcacctt agagtcgtga tctttggggt tggttgcttt ggggaatttt attataatga
     1021 cgatgacttc agtttcttgg ttgttaatta gaatatattg atgaccagct ggcctttgtt
     1081 ttgacatact ggcatagaaa ggatgttgtc cagcttttag aaagctaata gcagcagcct
     1141 acatgttgtg tattttttaa tctcacttag ctctgccagg agaatacagg gtccctggtg
     1201 tggtcttctg ggccactcct gactattctc acctaccctc ccataacaac tcagttctct
     1261 tgagggcttg agactttaca ctgtttagcc ctcacactct tttggcttcg ttactttcaa
     1321 tccctgattc tgcttctgta aagtgtatca gtttgttatt aaatgacagg attaactgtg
     1381 gggtctgtaa gctgtagtgc aggacgataa caggacgggg ctggatgcgg ttgtctttgg
     1441 tatcacatgg tgtgcatgtg ttctttcctt caccctcatt cctagactct atttatgtag
     1501 gtgtagggac tgcctggtgc ttgcttgtgc caagcaccct gccaactttt atggcctccc
     1561 aaagcattcc tgtaccaaag aggaatcagc agatccacac attcccttcc gtgccgttat
     1621 tttaagttgg gaattgttag aaaggaacca ttagccacag tgtcatcagt ttctaaatcc
     1681 tcacagcagt gatagatact ctttaacttt accactaagt ccctagagga ttaatgttcc
     1741 tgccctctcc atcctcagac ttttagttgt agcttatttt aaaaactatt ttcatggaag
     1801 accatcgcct cagaaaccaa caggtcttga cattagcttt ttgacacaac cttctcccac
     1861 aacaaactac tcctttttga tttactctta ctttgctatt atttctgctc ctgttctgtt
     1921 ctttttgtcc cctgaaaatg tccatcttct cttcattcct ttcttcttat atagttgagg
     1981 agactgagaa tcaggactaa atgtaaggaa ataacagggt ttggagctga gcactctttt
     2041 tttttttttt cccccccccc cggagctggg gaccgaaccc agggccttgc gcttcctagg
     2101 taagcgctct accactgagc taaatcccca gccccaggag ctgagcactc ttgacccagc
     2161 tcaaaagctg aggaaaagga gtaaacgctg agatagcctt aattctagac tttatcaact
     2221 actgaggctg tttttgttgt tcctttcggt ttttaaagca tagctatctg agcagccacc
     2281 catttctaga tcgttcatgg taatgagggg aaggagtgga gtgctctggt ccacagatga
     2341 cccaagtgtg tgcacgtcct agacccattc agtgtttgct agcatcactt ctctgctcag
     2401 ctgccactga gctctgtgtt cttgaataaa ttatgtcaac aattatactg cacagttgac
     2461 aggacagcca ggaagaacct gtgaatggta ctgtggtagg ggaagagcac ctaaccctta
     2521 cctctccgta gttcattctc tgaagatggt agaggcaagc tcaaaggctg gataagtgac
     2581 cattgtctgc ttaacttgat gaaatgcagg tggttagaga gcagatgtgt ccttcacgca
     2641 acctagacta gtaattaggg cagatgaagg tagcccagaa gtggcccagt tcctgaggat
     2701 cttagtctct gattagcagc tggagggaag gacagcctgc tgagcactca gcagcagtgg
     2761 gctgtaaact ggcagtggaa ggactgagta tacagtttga ggatttaatg ccttgtaatg
     2821 caaaaaatga agggaaggag tggcctgctg gttttaatgc tctttacaat gtttttccct
     2881 ctcaaaagtt catggagtat tggttttctg ttaattatta ccaaaactct cttgtccgtg
     2941 tctccccccc ccccccccca gctggggacc gaacccaggg ccttgcgctt gctaggcaag
     3001 tgctctacca ctgagctaaa tccccaaccc cttgttttcc tcttagtaag tttcctggtt
     3061 atatatagaa atagggaacc gggattccag tattctcttc agctctcagt atgaagaagc
     3121 cagacaccca tttgtgcctc cagcctgtgt tgtgccaagt agcttgattc tgctggagaa
     3181 ttgcagctgt ggacaaaagt gtttcctaga gttatcttct atcttcgctc taaagagttc
     3241 atggccaaag gtgaaagaaa tactcctaaa cactgactat attctcctgt gttaaccctc
     3301 tccagaacta attttgtggt actggaaatt gaacctagga ccagcgtgga cagccgggca
     3361 actgctgtgc catttttgtc tgcccccttt cctcccctgc catacagttg atggatcacc
     3421 aaattcacct gtttttgttg ctctaaggac tttaagtcac tgataccaag ctaaccttgg
     3481 ttgtataacc aagttgaatt cttttttttt tttttttaaa cttatgtgac tatgttgttg
     3541 ctgtcttcag acacaccaga agaaggcatc ggatcacatt acagatggtt gtgagccacc
     3601 atgtggttgc tgggatttga actcaggacc tctggaagag cagtcagtgc tcttaaccac
     3661 tgagccatcc tccagccctg ctaagttgaa ttcttttttt ctttttttct ttttcttttt
     3721 cttttttccg aagctgggga ccgaacccag ggccttgcgc ttgctaggca agcgctctac
     3781 cactgagcta aatccccaac cccctaagtt gaattcttga tctcctgcct cttcccagtc
     3841 tctaggatta taggtatgtg ccaccatatc tggctcttag ctccttctat atggagttat
     3901 ctgtgctagc caggtacagt gtaatacacc tttatttcca gtctttagga ggcagaagta
     3961 gataaatctt aatcggaggc ctgcctggac tatatagtga gttctaggcc agccacacct
     4021 acatagatct tgttgtgaaa ggaaaaatag gaaaagagta cccagattgg ccttgaactt
     4081 aggatcttta tgtatcagtt gtatgccact atgcctggct caaaatgcct ttttttttct
     4141 ttattaactt gagtatttct tatttacatt tcgatttttt ttaagttata tatatatgtg
     4201 atttctgcct gcatgtatat gcaccatatg catgcctggt tccctaggag acagaagagg
     4261 gtctcatatc ctcttagata ggagtgagcc actatgtggg tgttgagaat cagatctgga
     4321 agagtagtca gtgctcttaa ctgctgagcc atctcccacc cttcaaaaca tctttctaaa
     4381 gttgaatttc ttcccccccc ccttttctgt ttagtcctga ctgtttcttg ctggcttcac
     4441 cctctagtgc tcacgttttg ctagctttgt gcaaaaacag gtgaactggg tgatccatcc
     4501 tcaattttac acattgtgtt gttcacattt ctacaacttt agcatacatc aatattgttt
     4561 tcattcaaca aacagttttg gctcaggaac tcgctagaga actttgatag tggtgtggga
     4621 tgagttgatc agtatagttt tggataatga atactgcaca tgtatataaa ttactggtct
     4681 gggacagcat caggtataca aaaaggtgag tctttagtgg gcagttagtt aagtggttga
     4741 gtgctggtga ggaatccatg aagccctggg tttccacggg ggggggggta aggtaaatct
     4801 gcagtaggag gggggggtaa ggtaaatctg cagtaggagg ggggggtaag gtaaatctgc
     4861 agtaggaggg tgccattaac tgcttcatct gtgggaaaga ctgtggtctt ggatgaactg
     4921 agttaactgg ccatgggcag cattgcagga aataaagcta gaaaggcttt cgtttcgtta
     4981 ccaagagtgc agatgaatga gcgtgagaac tgtcttgttt agactgccaa gcattcatga
     5041 ctgtgttagt attgcctgtg ctggtgtata tttcttcttt gtgggcgttt tagcaagttg
     5101 ctcacactgt tcaatttctc acccttttgg agaaatcaac attagtctgg ctttaaagcc
     5161 caaaacatac catctaatga caagacttcc ttagaacaaa gcttaggaat gagctacctt
     5221 tggatcacgt gggtctcagt gccagggagt aagcagctcc tgtgtcactt atatcaaaac
     5281 cttccacagg aataatgtgc tctggctcct cattgtgcgt gacacccttc tcagagaagg
     5341 aaaggtctgt ttttcaggtt cttattctga ctcctgagag cccaagacga agatgtaatt
     5401 gactgacttt agaagtcaga attcccagaa attcaactaa ctgctctaga aggttaaaat
     5461 gtgaagtttc ttgtttgttt tttgcttgtg ctgaatattt tgaattttca tctacctcgt
     5521 cttatttttc ttagttactt ctgtcattac cacttgagca tcaagcttga ttttggtcat
     5581 tgtctaaaat ggggtctctc ctgttcagtg acagtttatt cccttgtctt tcctcttggc
     5641 cctcatttca cctaacatca tctcttattg ctcctgtcag aaatatgttt taaagtcttg
     5701 ttttatggga aaaagtggtc caccaatgct gtttgtctct gaggtcagtg agagaaggag
     5761 ttaaaacaca gtggtggagg aagggcagag cctgcctgca ctggaggcaa aagctgacaa
     5821 ggaaggagtc attaattaaa gacaatttca aagtcaactg attgtgatca ttaatgtcac
     5881 aatagatcaa aacctaatta tcacagccta ggtaagagcc atcagtatta atcggaaaat
     5941 ctaataggaa actattagca agaaattagg ccaaattgaa tgcaatgaac tttttatcat
     6001 ctttttttgg taatgttctt ggtgttggca actgtgaccc taacagttgg tccaagccca
     6061 gattgctaat tttaaagagc cttttttttt ttttttttta agtaacccag gctgacccta
     6121 gtgcttacag ccctccagct tcagccttga gcactgggat tatgaggggt acatgcattt
     6181 gtgtttgtgt gggtgggtag gagagaattg aactcagggc cttgtacatt ttagacaagt
     6241 gctctaccac tgaactgtat tcctagctca gagtgttttg tttgttaggg aagtttccag
     6301 acagactgaa cctaagctga cattgctgaa acaccagcct tgaatttttt tatcatatgg
     6361 atctattcat tctaatcaga tcagcgggat ataaacatat atattaaagt cgtagagtgt
     6421 ccctagtgaa catcatatca tctgttgagt gcttgtatat agagttctat actggttgtt
     6481 gtgaaggctg tgggaggaag gcagtgtcct gctttgaaat tctttgaaaa ctaaaaagat
     6541 agtttccttg tgtgacagca tgatcaagat gcaagtctgt gtttttcagt ttccattagc
     6601 attagggttt gatcctaaac cagcttagca gtgcccccaa ccccaatagt tttaagatag
     6661 gcacaaaatg atttcctact ggaattctaa ggtatgggga agacatcttt gtttctgttt
     6721 tcctttctgg tagtaggaga agcatcagta tgtccttaag atgtttgtaa agatgctacc
     6781 ccctttaggt gagatgagtc aggctgtgga acggttgctg tcacaggagg agtgccaggc
     6841 agtagtagag ggaattgtgc ttaggagtct gcactgtgcc ctgcagccct cagatgctca
     6901 gtgctgacct taggaggccc atgctgcttt ctggaccttg ggaacctgga ttacccagta
     6961 gaagactgag aatcaatgtc ttttgtttgt ttgtttattt tttgttctgt ttttgttttg
     7021 ttttgttttg ttttccaaga tggggtctct gtgtagccat ggatgtcctg gaacttgctc
     7081 tgttgaccag actggcctcg aactcaaaga tctgcctgcc cctgcctccc aagtactgtg
     7141 atcaaacgtg tgcgccatca ctgcctggct aacccttcac ttcttagtga gttttagtgt
     7201 ttaaaaaatg caacttaatt ttcaaagtgg cactaaggtg gtttgtccag ccttgggtta
     7261 ctccaggtga gcagcagccc tcaattaaca gtgtgttgat tggactcatc cggctgcagt
     7321 gaaatgactg aaagtgagat gttctagtgc atagttctgt gctaacctcc tacttggtct
     7381 taatggctga ccttgggcaa gtctttcctt tcaatgcctc agttccccat ctgtcaaatg
     7441 gggtgataat actgacctac ctcatggggt gttgtgaggc attacagatc agagctgatc
     7501 aaccctttag gattgcctgt ggaggatacc ttaagtcgga ctcttttagc cctcactgag
     7561 ctacttccaa gtttggaagt agttagtgac cttggcgagt ttctgtcccc ccacccttta
     7621 cccctcatca aagctgctag ttcagatgtt aacagtgttt tgtgaatgtt ggagtcttga
     7681 tcgtccagtc taacttggga caatgtaagg gaaggcactt gtgggttctg tgtcttatat
     7741 tacaaagaga ctgttagaaa ttcaagagcc ttggtttagg aatcttgagg caggaatgct
     7801 accgcatgtc tttctctgca ggagttaagg tcctattctc atggacttat aactacttct
     7861 gactgtcttc gaaaggaagt gacacttggt attttggatt tatattgttg ctttcatttt
     7921 ccagactgat cctaggacag ttagtctact gaacccttca tgcttctatg cctctgccct
     7981 ctcatagaag ccagatggtt caagcaacat agctctccct tcccccacca aaaagctgta
     8041 ttggattttt gtttttttgt ttctagaaat aggtgtaaca tttcagaatt gagcattggt
     8101 cctcaaggct tcttccagtt cactgtgtgt ggaatctgtc acctcttttc agtgtccacc
     8161 atctgaccca ctgaggacat cttggacact tgtttgccca cttgagggtt caaaagcctt
     8221 actctgtgtt tcagtatagg gctaaggcat ccccaagctc ttcgtgatag gtttcctttc
     8281 ccctacttga ccttgtattg gtaccatgaa aaagcacaca gtcctagctc cctggaggta
     8341 cacactccag tactgttagg tggactctac tcctaacagg gatcctagag ggttctctgg
     8401 aggatgggaa aggagcagtc tcatgtcctg ccaagtagta gccagcagtt gccttacccc
     8461 tgcctgctgg ccatgttccc acctcctcat ggagagggct ttcagaggtc ctcgaggctg
     8521 gattttctca gtctctgctg tgccattctg agtgggaagc agaccacact ttgtggccag
     8581 gtgtctaagt ggaagtgagg tcttgaattc tcggtggact ttttggtttg tgggggagtt
     8641 ttggttgtgt ttcttggttc tatttcagcc aaactcgcct gcttttgatt tctttaaagg
     8701 ataagtggtc tatctatcta tatacatgta tgtttgcatt ttaagtgtaa atgttttgaa
     8761 aaaaaaaaac agacatgtct ttctataact gacatccgat tcagacatca ttctctcccc
     8821 ttccaccctc ttttccctct tttcatactc ttgtattggt tctaataaag gattgctttt
     8881 caaatatg
//
LOCUS       NM_001437900            4309 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 4, mRNA.
ACCESSION   NM_001437900 XM_039078860
VERSION     NM_001437900.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078860.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.41662.1,
                                           SRR26643296.20655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-312             JAXUCZ010000007.1  122187562-122187662
            313-468             JAXUCZ010000007.1  122194723-122194878
            469-551             JAXUCZ010000007.1  122198007-122198089
            552-599             JAXUCZ010000007.1  122198472-122198519
            600-842             JAXUCZ010000007.1  122203808-122204050
            843-1029            JAXUCZ010000007.1  122207498-122207684
            1030-1167           JAXUCZ010000007.1  122210547-122210684
            1168-1233           JAXUCZ010000007.1  122213276-122213341
            1234-1346           JAXUCZ010000007.1  122216165-122216277
            1347-1460           JAXUCZ010000007.1  122216625-122216738
            1461-1587           JAXUCZ010000007.1  122218925-122219051
            1588-1740           JAXUCZ010000007.1  122220112-122220264
            1741-1956           JAXUCZ010000007.1  122223641-122223856
            1957-2021           JAXUCZ010000007.1  122225088-122225152
            2022-2137           JAXUCZ010000007.1  122226909-122227024
            2138-2223           JAXUCZ010000007.1  122228286-122228371
            2224-2304           JAXUCZ010000007.1  122228849-122228929
            2305-2402           JAXUCZ010000007.1  122229298-122229395
            2403-2460           JAXUCZ010000007.1  122229728-122229785
            2461-2582           JAXUCZ010000007.1  122230077-122230198
            2583-2746           JAXUCZ010000007.1  122230444-122230607
            2747-2903           JAXUCZ010000007.1  122231523-122231679
            2904-2992           JAXUCZ010000007.1  122231770-122231858
            2993-3188           JAXUCZ010000007.1  122232571-122232766
            3189-3416           JAXUCZ010000007.1  122235416-122235643
            3417-4309           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4309
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..312
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..468
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..551
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    529..531
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            552..599
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..842
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..3465
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 1"
                     /protein_id="NP_001424829.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLVSTHHLHSSSEDEDIEGTFPNELSLQQAFS
                     EYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIEADEDSPSAALFEAC
                     CSDRIQPFDDDEEDIWEDEETRCTARVMARARFGAPHTSENYSKKAVGHGGQGRKTGS
                     PTARNVPGLATPSSPTQKEGPRSESDSAGTTWTAVFDEPVNPLSAASGAARDVGSSAW
                     AAGPSVAEEKGWAKFTDFQPFCCSETGPRCSSPVDMDHSNAEGGQSPGPEKAFGPTSP
                     CAWNVCVTRKAPLVASDSSSSGGSDSEDDEKAAGAVEALCAGHTGKASPPPRTAEAAA
                     GRAECPDSTVLAPACPAPSEVTISPAVATIAPSKAGSPTATIVVSSSVATAVPPGPIM
                     AVTTTAPAIVATLGTMTKDRKTDALPDGAALNGPV"
     misc_feature    997..2217
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    997..2217
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2548..>3435
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2548..>3435
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            843..1029
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1167
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1233
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1346
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1460
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1587
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1740
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1956
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2021
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2137
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2223
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2304
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2402
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2460
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2582
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2746
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2903
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..2992
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3188
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3416
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..4309
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggttctcagc cttggctgtc ctggaactct
      241 ctccatagac caggcgggcc ttgaactcat agagatctgc ctacctctgc ctcctgagtg
      301 ctgagatcaa agtctctacc acagcgcgtt ctgttggact ctttcacgga actataggat
      361 cacatgggca gcacttgtgt ttgattctac cctctttctt ccggtcggtt ctgtcaccct
      421 gggaaataga gaagcagaac gtacggctcc tttcttcatt cactgctgga tcaatgtcca
      481 gggccaaggc agttttgttt gtgtggattt ctgtttactg ctgcatggta gaggctgccg
      541 aaccccataa ggaaacattg ttgcggtttg cacatccagt ctgagagact tctgcattgc
      601 tctgtgacca ccatcatgtt ctggaaattt gacttgaata ccacgtccca cgttgacaag
      661 ctcctcgaca aggaacatgt gacactgcag gaattaatgg atgaagatga catcttgcaa
      721 gagtgtaagg ctcagaacca gaagctgctg gacttcctgt gcaggcagca gtgtatggag
      781 gagctggtga acctcatcac acaagaccca ccccaggaca tggaagagaa ggtccgattc
      841 aaatatccaa acacagcctg tgagcttctg acttgtgatg tgccgcagat cagcgacaga
      901 ctaggcgagg acgagagtct gctgaacctt ctgtatgact tcttggacca ggagccacca
      961 ctcaaccctc tgcttgccag tttttttagc aagaccattg gcaatctcat tgcaaggaaa
     1021 accgaacagg tgatcatgtt cttgaagaag aaggacaagt tcatcagtct gatactgaag
     1081 cacataggca cctcagctct catggacctg ctgctacgcc tggtcagctg cgtggaacca
     1141 gttgttctcc ggcaggaggt cctacattgg cttaatgaag agaaagtcat ccagagactt
     1201 gtggaattga tccatcccca ccaggatgaa gataggcagt caaatgcttc tcaggcactc
     1261 tgtgacatca tcaggctggg cagagaccag ggcagtcagc tgcaggagac tgtggagccg
     1321 gatcccctcc tcacagcact ggagtcgcag gactgtgtgg aacagcttct gaagaacatg
     1381 tttgatgggg atcggacgga gagctgcctg gtcagtggga tgcaggtgct gcttgccctg
     1441 ctggagccaa ggcgtgttgg aacagaaggc ttggtggact ccttttctca gggactggaa
     1501 aggtcatact ctgtcagcag cagcatcctg cacggcattg agccatggct gaagaatttc
     1561 catcagctcc tgctcaaccc accaaagaag aaagcaatcc tgaccactat tggcgtgcta
     1621 gaggagcccc tggggaatgc tcgtcttcat ggtgcacgcc tcatggctgc actgctgcac
     1681 acaaatacgc ccagcatcaa ccaggagctc tgccggctca acaccatgga cttactgctg
     1741 gacctgtttt ttaagtacac ctggaataac ttcttacact tgcaagtgga gctgtgcata
     1801 gccgctattc tctcccacgc tggtcgggag gagcaggcag aagctggcag atcagatggc
     1861 aaagtggaac ctgtgcaggg gagtggagat gggggtggga agccggagac caccccgtcc
     1921 atcaccagcc ctcctgagaa cacaatggtg acccatctgt tccagaagtg ctgcctggtt
     1981 cagaggatcc tggaagcctg ggaagccaat gacaacacac aggcggcagg tggcatgaga
     2041 cgtgggaata tgggccacct cacaaggatc gccaacgcag ttgtacagaa cctggagcag
     2101 ggcccggtgc agacacacat cagtgaagtc atccgagggc tccctgcaga gtgccgtgga
     2161 cgctgggaga gctttgtgga agagacactg atggagacca accgcaggaa cactgtggac
     2221 ctggtgagca ctcaccacct tcactcctca agtgaggacg aggacattga gggtactttc
     2281 cctaacgagc tgtcccttca gcaggccttc tctgagtacc agatccagca gatgacagca
     2341 aactttgtgg atcagtttgg cttcaatgat gaggagtttg cagaccagga tgacaacatc
     2401 aatgccccat ttgaccggat tgcagagatc aacttcaaca ttgaagccga tgaggacagt
     2461 cccagtgcag ctctgtttga agcttgctgc agtgatcgga tccagccctt cgatgatgac
     2521 gaggaggaca tttgggagga tgaggagact cgatgcacgg cccgggtgat ggccagagcc
     2581 aggtttggag cccctcacac ctcagaaaac tactcaaaga aggccgtggg acatggaggc
     2641 cagggcagga agactggctc ccccacagct aggaatgtgc ctggactggc cacgccttca
     2701 tcccctacac agaaagaagg tcctcgctca gaaagtgatt cagcaggtac tacatggaca
     2761 gcagtttttg atgagccagt gaacccgctg tctgcagcct caggagctgc gagggatgtg
     2821 ggttctagtg catgggcggc tggtccttca gttgcagagg agaaaggctg ggccaaattc
     2881 accgacttcc agcctttctg ctgctctgag acagggcccc ggtgcagctc tcctgtggac
     2941 atggaccaca gcaatgccga gggtggccag agtccaggcc cagagaaagc ctttggtcct
     3001 acctcgcctt gtgcctggaa cgtgtgtgtc actaggaagg ccccactggt agcctctgac
     3061 agcagctcct ctgggggatc tgacagtgaa gatgacgaga aggcagcggg tgctgtggaa
     3121 gctctgtgcg caggccatac tggaaaggcc tccccgccac ccaggacagc agaggctgct
     3181 gctggcaggg ccgagtgtcc tgacagcacc gtgttagccc ctgcctgccc tgctccttca
     3241 gaagtgacca tcagtcctgc cgtggctacc atagcaccaa gcaaggcagg ctctcccaca
     3301 gccaccatag tggtctcttc ctcagtggct actgcggtac ccccaggacc aatcatggca
     3361 gtaaccacaa cagctccagc catagttgca accctgggga caatgacaaa ggacaggaag
     3421 acagatgccc tgccagatgg agctgcctta aatggccctg tgtaatggct gccgcccagc
     3481 tatggcccac cctggtcagg ctgcctcctt aatcaagaag actacctggt gatgcaattt
     3541 tttttaattt aactttaaaa taaatgctgc atttggtaaa gctggcagtg gaacccgttg
     3601 gatgacccag ctcatgtttc tcctgcctgc ccttggtcct gttggaggac aggatgcacc
     3661 tggccattcc caggcccagg tcttggtgtg gcaatgcagc cctgacgcgc agcttcaacc
     3721 tgcaggagtt ggggagggaa caagacccta aggggccagc accatcggat gggcaggaag
     3781 ggtgcggatc tccaggcgct ggtttcatct gtatttttaa cgcatggagg aaaagccgtt
     3841 ttttgcactt tgtacccagc tacagtacag ggtctctcta ggctcagggc agatgtacag
     3901 gcctgagttg gagagacctg atccccacta ataatactac atgggggtct ggcactagtt
     3961 tggccacatg aggtcaaacc ccagttctag ctgcccaggg actcctggga gctggtgttg
     4021 aatcaggcta cacattttga ctgccttaaa aacaaagacc ctctggaccc ggtgcagtgg
     4081 tctctgtgct cagcagggca gactggcaca ctcgggtggg ggttggagct gcaccagaca
     4141 tgtaagagtg gacacggaag agcactggga ggcctaggga ccgggcgggc ccatagtgtc
     4201 caggaagagt ctaaagtcta tgttgtcttt tttttttttt ttttttaaat gttctgacct
     4261 tctgacaggg catctaaccc ccaataaaaa ggatcattct tactgaaaa
//
LOCUS       NM_001437905            2765 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 2 (Amigo2),
            transcript variant 3, mRNA.
ACCESSION   NM_001437905 XM_063263370
VERSION     NM_001437905.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Li,Z., Khan,M.M., Kuja-Panula,J., Wang,H., Chen,Y., Guo,D.,
            Chen,Z.J., Lahesmaa,R., Rauvala,H. and Tian,L.
  TITLE     AMIGO2 modulates T cell functions and its deficiency in mice
            ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   Brain Behav Immun 62, 110-123 (2017)
   PUBMED   28119027
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Kanda,Y., Osaki,M., Onuma,K., Sonoda,A., Kobayashi,M., Hamada,J.,
            Nicolson,G.L., Ochiya,T. and Okada,F.
  TITLE     Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to
            Liver Endothelial Cells Resulting in Liver Metastases
  JOURNAL   Sci Rep 7, 43567 (2017)
   PUBMED   28272394
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Park,H., Lee,S., Shrestha,P., Kim,J., Park,J.A., Ko,Y., Ban,Y.H.,
            Park,D.Y., Ha,S.J., Koh,G.Y., Hong,V.S., Mochizuki,N., Kim,Y.M.,
            Lee,W. and Kwon,Y.G.
  TITLE     AMIGO2, a novel membrane anchor of PDK1, controls cell survival and
            angiogenesis via Akt activation
  JOURNAL   J Cell Biol 211 (3), 619-637 (2015)
   PUBMED   26553931
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Rabenau,K.E., O'Toole,J.M., Bassi,R., Kotanides,H., Witte,L.,
            Ludwig,D.L. and Pereira,D.S.
  TITLE     DEGA/AMIGO-2, a leucine-rich repeat family member, differentially
            expressed in human gastric adenocarcinoma: effects on ploidy,
            chromosomal stability, cell adhesion/migration and tumorigenicity
  JOURNAL   Oncogene 23 (29), 5056-5067 (2004)
   PUBMED   15107827
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263370.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.32160.1,
                                           SRR26643295.29979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000007.1  130273443-130273753 c
            312-2765            JAXUCZ010000007.1  130270639-130273092 c
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2765
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
     exon            1..311
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    145..147
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="upstream in-frame stop codon"
     exon            312..2765
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1932
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="amphoterin-induced protein 2; alivin 1; AMIGO-2;
                     amphoterin induced gene 2; transmembrane protein AMIGO2;
                     transmembrane protein AMIGO2-like"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_001424834.1"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
                     /translation="MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTAC
                     ICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHN
                     NITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAF
                     GGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQ
                     LRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQD
                     SFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDK
                     DTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHA
                     HEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPT
                     RDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSETVIAEGILKSSRAKSDSDSVN
                     SVFSDTPFVAST"
     sig_peptide     370..480
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     mat_peptide     481..1929
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /product="Amphoterin-induced protein 2.
                     /evidence=ECO:0000255. /id=PRO_0000014512"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     misc_feature    517..582
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    517..582
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    538..540
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    571..636
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 1"
     misc_feature    <574..>1056
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <574..>1056
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    583..651
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    583..651
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    646..711
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 2"
     misc_feature    655..720
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    655..720
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    676..678
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    718..783
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 3"
     misc_feature    721..792
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    721..792
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    790..855
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 4"
     misc_feature    793..864
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    793..864
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    862..927
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 5"
     misc_feature    865..945
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    865..945
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    943..1008
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 6"
     misc_feature    1024..1062
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1024..1062
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1207..1209
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1228..1230
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1258..1470
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1258..1470
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1282..1296
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1282..1296
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1324..1338
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1324..1338
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1378..1392
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1378..1392
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1399..1401
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1444..1461
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1444..1461
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1483..1485
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1507..1509
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1516..1518
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1528..1530
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1564..1626
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     transmembrane region"
     misc_feature    1678..1743
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1861..1929
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 gggccctgca gcctgcgagc gccaccggcg ggccggcttt ccccgccgcc caccccgctc
       61 ccggcgcggc cgagctccgg cggtacctgc agccgagcca gagagccggg gagccctcgc
      121 cgccgcctcg aaactcgcca aagttgagag gctgccgccc accgggagct ggagggaagg
      181 tgcgagcgcg cggggcgcga accggcagac ggacgcgcgg accttctgag cgcaccgccg
      241 tcggcggcct ctcccgagcc gctgcggctt ccccgcgctg tgagtggtcg gctagaccga
      301 cggctggcta aattggtggg aggctgtgct ggtgagaagc gactggcaag aggctcagag
      361 gcgaccataa tgtcgttaag gttccacaca ctgcccaccc tgcctagagc tgtcaaaccg
      421 ggttgcagag agctgctgtg tctgttggtg atcgcagtga tggtgagccc cagctcctca
      481 ggactgtgcc ctacggcttg catctgtgcc actgacattg taagctgcac caacaaaaac
      541 ctgtctaagg tgcctgggaa ccttttccga ctgattaaaa gactggatct gagctataac
      601 agaatcggac tcctggatgc cgactggatt ccggtgtcgt tcgtcaagct gagcaccctg
      661 attgttcgcc acaacaacat caccagcatt tccacgggca gcttctccac cactccaaat
      721 ttaaagtgtc tcgacttatc gtccaatagg ctgaagtcgg tgaaaagtgc catgttccag
      781 gagctaaagg ttctggaagt gctcctgctt tacaacaacc acatttccta tctggacccg
      841 gcagcgttcg gagggctctc ccacttgcag aaactctacc tgagtgggaa cttcctcacg
      901 aagttcccta tggatttgta tgtcgggagg ttcaagctgg ctgatctgac atttttagat
      961 gtttcgtaca atcaaattgc ttccatacca atgcaccaca taaatttagt gccgggaaag
     1021 cagctgaggg gcatcttcct tcacgggaac cctttcgtct gtgactgttc cctgtactcc
     1081 ttgctgacct tctggtaccg taggcacttt aactctgtga cggatttcaa gcatgactac
     1141 acctgtcgcc tgtggttgga ctccaggcac tcccaccagc tgttgctgct ccaggatagc
     1201 tttctgaact gttctcacag cgtcatcaac ggctccttcc acgcacttgg ctttatccac
     1261 gaggctcagg ttggggaaag ggcgattgtc cactgtgacg gcaaaaccgg taacgggaac
     1321 accgatttca tctgggtggg tcccgacaac aggctgttgg agccggataa agacacgggg
     1381 aactttcgag tgttttacaa cggaagcctg gttatagaga accctggttt tgaggacgcc
     1441 ggggtttact cctgtatcgc catgaacagg cagcgcctgt tgaatgagac ggtggacatc
     1501 atgataaacg tgagcaattt caccataaac agatcccacc acgcccacga ggcatttaac
     1561 acggctttca ccaccctggc tgcctgcgtg gtcagtatcg tcctagtgct actgtacctg
     1621 tacctgacac cgtgtccctg caaatgtaga gacaagagac agaaaaacgc actgaaccaa
     1681 agcaacgccc attcgtccat tctcagtccc ggccccaccc gggatgcctc tgctgaggat
     1741 cggaaggcag gtaaaagagt ggtgtttttg gagcccctga aggatccagc ggtgggacag
     1801 aatggaaaag tcaagcttgt ccccagtgag accgttatag ccgagggcat cttaaagtcc
     1861 tccagggcaa aatctgactc agactcggtc aattccgtgt tctcagacac acccttcgtg
     1921 gcatccactt aaccgtgtgc ctgtgttcgt ctggtgtcgt gatttgacct ctccctaccc
     1981 aactgcagtc cacgaaatta gtagcaggag agaaactgtt ttgtcttttt gagagaaaac
     2041 caaatggtgt ctttatgatg gttgctagga agtgaggcag agcaccctgg ttgcttcctc
     2101 gtgctgggta aagatccagt tgattttgag agtcttaagt tcccagtaac agccatcagc
     2161 atctttgagg atttcaggct ggcctgaagg cggtaggacc agccattatc tcctggttat
     2221 ctcggaggga aaaaaaataa agctatgtgt tagcattctt taaaaataga accttttaac
     2281 ttactagagc caaagttgag ctgagctttt cttattttta agaaaaacac gagtggcttc
     2341 tttcccctct aaaagatgta gaaggaagaa tcggttattt atagatcata aagttagcat
     2401 agaggttttt cagccgaaac catcatttcg gaccaggata gacacactag taacatccac
     2461 agaatcatgc cacgtcccat ggagtgcaca ggggcctagc ttttagctgt cttctccgtc
     2521 atctctgtgc tgtatcctgg tacaaaagat gccccccaaa aagttaaagg tgtctttatg
     2581 tgttgccaag agtatgtgtc actgccaaac tgtctgagtc actccctaca ccctcaccgc
     2641 agcagactca ggtttgtcca cctgcgtgtg tatatgtaaa accttaagtt ctatgaatgg
     2701 ccgtatagac cccaatgtac tgtattccag acatttaaat cagcgtaaat acacgtgctc
     2761 tgtga
//
LOCUS       NM_001108066            2425 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus AT-rich interaction domain 3A (Arid3a),
            transcript variant 2, mRNA.
ACCESSION   NM_001108066 XM_001076973 XM_234884
VERSION     NM_001108066.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2425)
  AUTHORS   Tidwell,J.A., Schmidt,C., Heaton,P., Wilson,V. and Tucker,P.W.
  TITLE     Characterization of a new ARID family transcription factor
            (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated
            immunoglobulin gene transcription
  JOURNAL   Mol Immunol 49 (1-2), 260-272 (2011)
   PUBMED   21955986
REFERENCE   2  (bases 1 to 2425)
  AUTHORS   Nixon,J.C., Rajaiya,J. and Webb,C.F.
  TITLE     Mutations in the DNA-binding domain of the transcription factor
            Bright act as dominant negative proteins and interfere with
            immunoglobulin transactivation
  JOURNAL   J Biol Chem 279 (50), 52465-52472 (2004)
   PUBMED   15456761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001108066.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168846.1, SRR26360181.2561555.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000007.1  10427860-10427986   c
            128-760             JAXUCZ010000007.1  10427109-10427741   c
            761-1076            JAXUCZ010000007.1  10426019-10426334   c
            1077-1149           JAXUCZ010000007.1  10411872-10411944   c
            1150-1333           JAXUCZ010000007.1  10409498-10409681   c
            1334-1581           JAXUCZ010000007.1  10408421-10408668   c
            1582-1878           JAXUCZ010000007.1  10407232-10407528   c
            1879-1977           JAXUCZ010000007.1  10406751-10406849   c
            1978-2425           JAXUCZ010000007.1  10405925-10406372   c
FEATURES             Location/Qualifiers
     source          1..2425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2425
                     /gene="Arid3a"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
     exon            1..127
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            128..760
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    147..149
                     /gene="Arid3a"
                     /note="upstream in-frame stop codon"
     CDS             390..2174
                     /gene="Arid3a"
                     /note="dead ringer homolog 1; AT rich interactive domain
                     3A (Bright like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     3A"
                     /protein_id="NP_001101536.2"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
                     /translation="MKLQAVMETLIQRQQRARQELEARQPPLPPPPEPAGVQARTTMT
                     DEDREPENARMHRTQMAALAAMRAAAAGLRHPSSPGGSEDEDTAQGGTLSSPALHGSG
                     QEGPGHTEGDGHLMDMGSDDDTKPKWEEQELEELGEEEEEEDEDDFEEEEEDEEEEGL
                     GLPESASLGSAGLFTRKAPPTQTFRGDGGPRMLSGPERLGPGPAHPSHVASQMPPPDH
                     GDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVL
                     VTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPN
                     ELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLSSPKLPVTSLGLAASTNGSSITPT
                     PKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREK
                     LESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDPAVNL
                     TSANGSNSISMSVEMNGIVYTGVLFAQPPPPTPPPASSKGGVSSIGTNNTMGNRTGAS
                     GSAGSSGQVGLAGVSAPTMSSTSNNSLP"
     misc_feature    1038..1436
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    1038..1436
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    order(1164..1184,1257..1259,1263..1268,1275..1277,
                     1299..1310,1314..1322,1326..1328,1416..1421)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     misc_feature    order(1164..1184,1257..1259,1263..1268,1275..1277,
                     1299..1310,1314..1322,1326..1328,1416..1421)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     exon            761..1076
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1149
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1333
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1581
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1878
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1977
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2425
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcttctt atgggacaat aaccccatgg tgtctctggt ggacctgccc agaggggacc
       61 cagagattcc cttggtgtcc actgcagtga ccctggtcct gaggaacctg cagacaggca
      121 gatgagggag tctgcaggtg cttgaatgag cccgacacca gcctctgccc ctgggtgccc
      181 gacgtaacaa caaggatccc actggtcgcc cctggcatgc cccaccagcc ttcaccctga
      241 gttggcagcc cccacccctg ccagccgtca ccctgcattg ttccggctcc cccgaagtcc
      301 ccacgctgca gtgcggccaa gacccctccc cacgggggcc acccccacca agtgcccctg
      361 gtgcccgggg tggcccggcc cgtcgggcca tgaagctgca ggcagtgatg gagactctta
      421 ttcagaggca acagcgagcc cggcaggaac tggaggctcg acagcctcca ctacccccac
      481 caccggagcc cgctggtgtc caggctcgga ccaccatgac agatgaggac agggagcctg
      541 agaatgcccg tatgcatagg acgcagatgg ctgcactggc tgccatgcgg gctgctgccg
      601 ccggcttgag acatccgtcc tctcccgggg gctcggagga cgaagacaca gcccagggag
      661 ggactctgag ttcacctgcc ctgcatggaa gtggccagga gggaccggga cacactgagg
      721 gagacggcca tttgatggac atgggctccg atgatgacac gaagcccaag tgggaagaac
      781 aagagctgga agaactgggg gaagaggaag aggaggagga tgaagatgac tttgaggaag
      841 aagaggagga tgaggaggaa gaaggcctgg gcctcccaga gtctgccagc ctgggctccg
      901 caggcctgtt tacccgcaag gccccaccta ctcagacctt ccgtggagac ggtggtccca
      961 gaatgctcag tggccctgag cgcctgggac ctggcccggc ccaccccagt catgtggcgt
     1021 cccagatgcc accaccggac catggggact ggacatttga ggagcagttc aaacagctct
     1081 atgaactgga cgcagacccc aagaggaaag agttcctgga cgacctgttc agcttcatgc
     1141 agaagcgggg cactccggtg aaccggatcc ccatcatggc caagcaggtc ctcgacctgt
     1201 tcatgctgta tgtgctggtg acggaaaagg gcggtctggt agaggttatc aacaagaagc
     1261 tgtggaggga gatcaccaag gggctcaacc tgcccacctc catcaccagt gctgccttca
     1321 cacttcggac acagtacatg aagtatcttt acccctatga gtgtgagagg cgaggcctga
     1381 gcagccccaa tgagctccag gctgccatag acagcaaccg ccgggagggc aggcgccaga
     1441 gcttcggggg ctccctcttt gcttactcac ccagtggagc ccacagcatg ctgtcctcac
     1501 ccaagctacc ggtgacttct ttgggccttg ctgccagcac caatggcagc tctatcaccc
     1561 caacacccaa gatcaagaaa gaggaagact cagccatccc catcacagtc ccaggccgcc
     1621 tacccgtgtc tctggcaggc caccctgtcg tagcagccca ggcagcggct gtgcaagccg
     1681 cagcagccca ggctgcagtt gcggcccagg cagccgccct ggaacaactc cgggagaagc
     1741 tggaatccac ggagcctccg gaaaagaaga tggccctggt tgcagatgag cagcagcgtc
     1801 tcatgcagcg agccgtgcag cagagcttcc tggccatgac agcccagctg cccatgaaca
     1861 tccggatcaa cagccaagcc tctgagagtc gccaggaccc agctgtaaat ctcaccagtg
     1921 ccaatggcag caacagtatt agcatgtccg tggagatgaa cggtattgta tacacagggg
     1981 tgctgttcgc tcagccacca cctcctacgc cacctcccgc ctccagcaaa ggtggtgtga
     2041 gcagcattgg taccaacaac accatgggta accggacagg agccagtggc agtgctggca
     2101 gcagcggcca agtggggctg gctggggtgt ctgcacccac catgtcttct acctcaaata
     2161 actccttgcc ttaaaaggaa accaagttgc atggctgccc acccgccaca ggaaccacat
     2221 ggccacacag ggggacctgg gacgtcagaa gaatcccagt gggctgggca gattcccaag
     2281 gagccacact gacgccaaaa aggagagaga gagatagaga gagaaagaga gagagagaaa
     2341 atatatatat atacatatat atatatacat atagaaagag ataggtagat ggagaaacag
     2401 atctaataaa tcagggcaaa gcaaa
//
LOCUS       NM_001437909            4065 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 3, mRNA.
ACCESSION   NM_001437909 XM_063282142
VERSION     NM_001437909.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063282142.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.9537.1,
                                           SRR26643295.9793.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000002.1  177791555-177791637 c
            84-213              JAXUCZ010000002.1  177786942-177787071 c
            214-291             JAXUCZ010000002.1  177784108-177784185 c
            292-402             JAXUCZ010000002.1  177782701-177782811 c
            403-604             JAXUCZ010000002.1  177779277-177779478 c
            605-700             JAXUCZ010000002.1  177778834-177778929 c
            701-746             JAXUCZ010000002.1  177775282-177775327 c
            747-859             JAXUCZ010000002.1  177774722-177774834 c
            860-919             JAXUCZ010000002.1  177771737-177771796 c
            920-972             JAXUCZ010000002.1  177768704-177768756 c
            973-1058            JAXUCZ010000002.1  177766872-177766957 c
            1059-1230           JAXUCZ010000002.1  177765163-177765334 c
            1231-1429           JAXUCZ010000002.1  177760418-177760616 c
            1430-1707           JAXUCZ010000002.1  177758391-177758668 c
            1708-1880           JAXUCZ010000002.1  177758048-177758220 c
            1881-2070           JAXUCZ010000002.1  177756072-177756261 c
            2071-2125           JAXUCZ010000002.1  177755325-177755379 c
            2126-2300           JAXUCZ010000002.1  177753749-177753923 c
            2301-2373           JAXUCZ010000002.1  177753274-177753346 c
            2374-2569           JAXUCZ010000002.1  177751968-177752163 c
            2570-2658           JAXUCZ010000002.1  177751792-177751880 c
            2659-2712           JAXUCZ010000002.1  177749533-177749586 c
            2713-2794           JAXUCZ010000002.1  177747255-177747336 c
            2795-3012           JAXUCZ010000002.1  177746302-177746519 c
            3013-3118           JAXUCZ010000002.1  177745433-177745538 c
            3119-3186           JAXUCZ010000002.1  177740434-177740501 c
            3187-3384           JAXUCZ010000002.1  177739078-177739275 c
            3385-4065           JAXUCZ010000002.1  177736374-177737054 c
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4065
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..83
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..213
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             124..3423
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 3"
                     /protein_id="NP_001424838.1"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGRECMHGALSKPAV
                     VRGQENGLDGTKSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEP
                     ANTDDNYGSSSGNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGAWRTATEEWG
                     TEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLD
                     PSQAPSLAQPLVFSNSKQNAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQ
                     FLEQFKTAQALAQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFT
                     KRQAFTPSSTMMEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSS
                     PQPAQQKLKQQKKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYEST
                     PTTSASSSQAPSSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQGPLYE
                     QRSTQTRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSESPSTS
                     SIPSLNETVPAASLLTTASQHSSSLSGLSHSEEIPNTTTTQHSSALSTQQNTLSSSTS
                     SGRTSTSTLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLG
                     SNSTVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQM
                     LQTRFPLDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQ
                     QNQTQTHHTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQH
                     GVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFH
                     SGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQD
                     ILTLVDDQLGE"
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    271..384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1702..1785
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1702..1785
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            214..291
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..402
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..604
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..700
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..746
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..859
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..919
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..972
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1058
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1230
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1429
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1707
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1880
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2070
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2125
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2300
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2373
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2569
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2658
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2712
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2794
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..3012
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3118
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3186
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3384
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..4065
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgaggt aaagttggca gcgcagcggc gttggcggcg gcggcggcgg
       61 cagcggcaac gcggcggggc cggtattctt ccttgtaaat actgttattt gtatatactg
      121 taaatgatga cgtcggtggg cactaaccga gcccggggaa actgggaaca acctcaaaac
      181 caaaaccaga cacagcacaa gcagcggcca caggccactg cagagcaaat tcgacttgca
      241 cagatgattt cggaccataa tgatgctgac tttgaggaga aggtgaaaca attgattgat
      301 atcacaggca aaaaccagga tgaatgtgtg attgctttgc atgactgcaa tggagatgtc
      361 aacagagcca tcaatgttct cctggaagga aatccagaca cgcattcctg ggagatggtc
      421 gggaagaaga aaggagtctc aggacagaag gatggtggac aaactgaatc taatgaagaa
      481 ggaaaagaaa atcgagaccg ggacagagac tatagtcgac gacgtggtgg gccaccaaga
      541 cgggggagag gtgccagccg tggacgagag tgtatgcatg gggctttatc aaaaccagct
      601 gtggttcggg gccaggaaaa tggattggat ggcactaaga gtggtggacc ttctggaaga
      661 ggcacagaca gagggagaag aggccgtggc cggggcagag gtagttctgg tagacgagga
      721 ggaaggtttt ctgctcaagg aatgggaacc tttaaccctg ctgattatgc agagccagcc
      781 aacactgatg ataactatgg cagtagcagt ggcaatacat ggaacaacac tggccacttt
      841 gaaccagatg atggaacaag acttgatttc attggggttg aggggtcaaa ttatccccga
      901 aaatttgaga ctgctcctgg tgcatggagg actgcaacag aagagtgggg aactgaagat
      961 tggaatgaag atctttctga gaccaagatc tttactgcct ctaatgtgtc ttcagtgcct
     1021 ctgcctgcgg agaatgtgac aatcactgct ggtcagagaa ttgatcttgc tgttctgttg
     1081 gggaagacac cgtcttcaat ggagaatgat tcatctaatc tggatccatc tcaggctcct
     1141 tccctggccc agcctctggt attcagtaat tcgaagcaga atgccatatc acagcctgct
     1201 tcagggaata cattttctca tcatagcatg gtgagcatgt tggggaaagg atttggtgat
     1261 gttggggaag ctaaaggtgg cagtacaaca ggctctcagt tcttggagca attcaagact
     1321 gcacaggccc tggctcaact ggcagctcaa cattctcagt ctggaagcac caccacctcc
     1381 tcttgggata tgggctcaac aacacaatca ccatcactgg tgcagtatga tttgaagagt
     1441 gcaaatgatt caacagtgca cagtcctttt acaaagcgcc aggcattcac cccatcatca
     1501 accatgatgg aggtgttcct tcaggagaag ccacctgcag tggctacctc gacagctgca
     1561 cctcctcccc cctcttctcc tctgccaagc aaatccacct cggctccaca gatgtctccg
     1621 gggtcttcgg acaaccaatc ctccagccct cagccggctc aacagaaact gaaacagcaa
     1681 aagaagaaaa cctccttgac gtctaagatt cctgctctgg ctgtggagat gcctggctca
     1741 gcagatatct cagggctaaa tctgcagttt ggggcattgc aatttgggtc agagcctgtc
     1801 ctttctgatt atgagtccac ccccaccacg agcgcctctt caagccaggc tcccagtagc
     1861 ctgtatacca gcacggccag tgagtcttca tctacagttt catctaatca gagtcaggag
     1921 tctggttatc agagtggccc aattcagtcg acaacttata cctcccaaaa taatgctcag
     1981 ggccctctat atgaacagag atccacacag acacggcggt atcccagctc catctcttca
     2041 tcaccccaaa aggacctgac tcaggctaag aatggtttca gctctgtgca ggccacgcag
     2101 ttacagacca cgcaatctgt tgaaggtgct acaggctctg cagtgaaatc tgaatcacct
     2161 tccacttcta gtataccctc tctcaatgaa acagtacctg cagcttcctt actgacgaca
     2221 gccagtcagc attcatcctc cttaagtggc ttgagccata gtgaggagat tccaaatacc
     2281 accaccacac aacatagcag tgcattatct acacagcaga ataccctttc ttcatcaaca
     2341 tcttctgggc gtacttcaac atctactctt ttgcatacaa gtgtggagag tgaagcgaat
     2401 ctgcattctt cctccagcac tttctctacc acgtccagca ctgtctctgc acctccccca
     2461 gtggtcagtg tctcctccag tctgaatagt ggcagtagcc tgggccttag cctgggcagc
     2521 aactctactg tcacagcctc aactcgaagc tcagttgcta caacttcagg aaaagctcct
     2581 cccaaccttc ctcctggagt cccgccattg ttgcctaatc catatattat ggctccaggg
     2641 ctgttacatg cctacccgcc acaagtatat ggttatgatg atttacagat gctccagaca
     2701 agatttccat tggattacta cagtatcccg tttcccacac ccaccactcc acttactggg
     2761 agggatggta gcctggccag caacccttac tctggcgacc tcaccaagtt cggccgcggg
     2821 gatgcctcct ccccagcccc agccacaacc ttggcccaac cccaacagaa ccagacgcag
     2881 actcaccaca ccacgcagca gacattcctg aacccggcgc tgcctcctgg ctatagttac
     2941 accagcctgc catactacac aggggtcccg ggcctcccca gcaccttcca gtatgggcct
     3001 gctgtgttcc ctgtggctcc tacctcttcc aagcagcatg gtgtgaatgt cagtgtgaat
     3061 gcctcggcca cccctttcca acaaccaagt ggatatgggt ctcatggata caacactggt
     3121 gtgtcagtca cctccagtaa cacgggcgtg ccagatatct cgggttctgt gtactccaaa
     3181 acccagcagt cctttgagaa acaaggtttt cattccggta ctcctgctgc ctccttcaac
     3241 ttgccttcag ccctaggaag tggagggccc atcaatccag ccacagctgc tgcctaccca
     3301 cctgccccct ttatgcacat tctgacccca catcagcagc cacactctca gatccttcac
     3361 catcacctgc agcaggatgg ccaggatatc ctcactctcg tcgatgacca gcttggtgaa
     3421 taagtattac cgtaccaact gggcctcttc tagcaggctc gaaggctgtg gaataaagtg
     3481 aaatctttgc cctttaagaa ctctcacctt aatgtgctaa tattttgccc ttaaggggat
     3541 tcccttttac atcctgtgac tgaaaagaac cactgcacat cttcatttct tctagaaact
     3601 gcctcaccta cagcaagttt caggaagtga aaggggaagg agctaaggac atttaaaagg
     3661 aaaaggacct tgtgggaatc taagcatgat ttaaaggatt ctgaaatctg aagccagcat
     3721 tatctactgt ctggcagaac caaattgtag ggcttttttc tttttggagg agtatagtag
     3781 ttcttgtctg agttatgttt ttgagacaat ctcactatgt aaccctgact ggctagaagt
     3841 tgtaacccaa ctggctggaa gttggtgtgg agaccaggct ggtctcaaat tcagagatct
     3901 acctgcctct acctcttgag tgccaaggtt aaaggttctc agcactatac cttaccttgc
     3961 cttttttatg tgactttgaa atgcctaagt tttgggaaag gagtggatga tggtagagca
     4021 agacctgggg tggggacatg gtgcagtaaa aggttttgga catgg
//
LOCUS       NM_001437944            7579 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 2, mRNA.
ACCESSION   NM_001437944 XM_063274024
VERSION     NM_001437944.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7579)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7579)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7579)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7579)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7579)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063274024.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.37513.1,
                                           SRR26643296.34889.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000015.1  105199266-105199522 c
            258-374             JAXUCZ010000015.1  105182942-105183058 c
            375-464             JAXUCZ010000015.1  105168842-105168931 c
            465-547             JAXUCZ010000015.1  105162379-105162461 c
            548-617             JAXUCZ010000015.1  105160417-105160486 c
            618-713             JAXUCZ010000015.1  105158803-105158898 c
            714-848             JAXUCZ010000015.1  105157736-105157870 c
            849-1023            JAXUCZ010000015.1  105151440-105151614 c
            1024-1091           JAXUCZ010000015.1  105149491-105149558 c
            1092-1166           JAXUCZ010000015.1  105137132-105137206 c
            1167-1307           JAXUCZ010000015.1  105135597-105135737 c
            1308-1505           JAXUCZ010000015.1  105134347-105134544 c
            1506-1628           JAXUCZ010000015.1  105133869-105133991 c
            1629-1711           JAXUCZ010000015.1  105129765-105129847 c
            1712-1834           JAXUCZ010000015.1  105129126-105129248 c
            1835-1914           JAXUCZ010000015.1  105124162-105124241 c
            1915-2102           JAXUCZ010000015.1  105123885-105124072 c
            2103-2168           JAXUCZ010000015.1  105123662-105123727 c
            2169-2261           JAXUCZ010000015.1  105122343-105122435 c
            2262-2385           JAXUCZ010000015.1  105120141-105120264 c
            2386-2507           JAXUCZ010000015.1  105119666-105119787 c
            2508-2594           JAXUCZ010000015.1  105118736-105118822 c
            2595-2684           JAXUCZ010000015.1  105117931-105118020 c
            2685-2800           JAXUCZ010000015.1  105115724-105115839 c
            2801-2870           JAXUCZ010000015.1  105113993-105114062 c
            2871-2996           JAXUCZ010000015.1  105113031-105113156 c
            2997-3068           JAXUCZ010000015.1  105111200-105111271 c
            3069-3215           JAXUCZ010000015.1  105101578-105101724 c
            3216-3299           JAXUCZ010000015.1  105101310-105101393 c
            3300-3411           JAXUCZ010000015.1  105100567-105100678 c
            3412-3590           JAXUCZ010000015.1  105098660-105098838 c
            3591-3704           JAXUCZ010000015.1  105098365-105098478 c
            3705-3822           JAXUCZ010000015.1  105096851-105096968 c
            3823-3956           JAXUCZ010000015.1  105091621-105091754 c
            3957-4071           JAXUCZ010000015.1  105089536-105089650 c
            4072-4138           JAXUCZ010000015.1  105087183-105087249 c
            4139-4186           JAXUCZ010000015.1  105085955-105086002 c
            4187-4230           JAXUCZ010000015.1  105082924-105082967 c
            4231-4346           JAXUCZ010000015.1  105076918-105077033 c
            4347-4484           JAXUCZ010000015.1  105074536-105074673 c
            4485-4667           JAXUCZ010000015.1  105074236-105074418 c
            4668-4781           JAXUCZ010000015.1  105072671-105072784 c
            4782-4997           JAXUCZ010000015.1  105072316-105072531 c
            4998-5055           JAXUCZ010000015.1  105069893-105069950 c
            5056-5133           JAXUCZ010000015.1  105069119-105069196 c
            5134-5240           JAXUCZ010000015.1  105067917-105068023 c
            5241-5363           JAXUCZ010000015.1  105053003-105053125 c
            5364-5477           JAXUCZ010000015.1  105051698-105051811 c
            5478-5624           JAXUCZ010000015.1  105050156-105050302 c
            5625-5835           JAXUCZ010000015.1  105046980-105047190 c
            5836-6026           JAXUCZ010000015.1  105035414-105035604 c
            6027-6127           JAXUCZ010000015.1  105031777-105031877 c
            6128-6266           JAXUCZ010000015.1  105031234-105031372 c
            6267-7579           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7579
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..257
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="upstream in-frame stop codon"
     CDS             138..6389
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 2"
                     /protein_id="NP_001424873.1"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MQADKYRTSGRNDKKELVIESPLQYKDAAQADSEAENSALAKPK
                     LIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEEEA
                     QSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADKDE
                     DAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEK
                     ISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKI
                     LQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVK
                     LFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVE
                     PFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQAA
                     MQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQ
                     ACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADFRK
                     PEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCI
                     PKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGR
                     PGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGST
                     KKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEVKW
                     VEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEG
                     HVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAY
                     KAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE
                     NNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFT
                     FMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQ
                     RYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDD
                     RYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGNPL
                     MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPD
                     RNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNK
                     ASTAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVAHQSL
                     LEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMAL
                     KNVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRN
                     NFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSF
                     SSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMAR
                     IHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPPVFPYSHTSCQRKSRGGMF
                     RQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIAD
                     IYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFE
                     DEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYI
                     QVTHVTPFFDEKELQERKTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTA
                     IHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQG
                     SVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKE
                     DQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQ
                     GLTSSSSVV"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    4932..6254
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    4932..6254
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5322..5324,5352..5354,5358..5363,5367..5372,
                     5379..5384,5388..5393,5400..5405)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5322..5324,5352..5354,5358..5363,5367..5372,
                     5379..5384,5388..5393,5400..5405)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5424..5435,5439..5441,5526..5531,5535..5546,
                     5550..5555,5610..5618,5667..5669,5673..5675,5760..5762,
                     5766..5768,5787..5792,5808..5810,5925..5930,5937..5939,
                     5979..5981,5985..5987,5997..5999,6006..6014,6021..6032,
                     6036..6041,6048..6050,6132..6134,6186..6191,6195..6200,
                     6207..6209)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5424..5435,5439..5441,5526..5531,5535..5546,
                     5550..5555,5610..5618,5667..5669,5673..5675,5760..5762,
                     5766..5768,5787..5792,5808..5810,5925..5930,5937..5939,
                     5979..5981,5985..5987,5997..5999,6006..6014,6021..6032,
                     6036..6041,6048..6050,6132..6134,6186..6191,6195..6200,
                     6207..6209)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    6021..6038
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    6021..6038
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            258..374
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            375..464
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..547
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            618..713
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1091
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1505
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1628
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1834
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1914
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2102
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2385
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2507
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2800
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2870
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3215
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3299
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3411
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3590
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3704
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3822
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3956
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4071
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4138
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4186
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4230
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4346
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4484
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4667
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4668..4781
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4782..4997
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5055
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5133
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5134..5240
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5363
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5477
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..5624
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5625..5835
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..6026
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6027..6127
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6128..6266
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..7579
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccaccc ctgaggctcc gcacttccag ccttgtgcct gggaaacagg cttccttgcc
       61 tttctctggc cagtggtgca gcaggggact ctcagctgtc cctgctgcag gctttctgac
      121 agtggtctgg gtggagaatg caggctgata agtacaggac tagcggtaga aatgacaaga
      181 aggagctggt catcgagtct cccctgcagt acaaggatgc agctcaggca gactcggagg
      241 cagagaactc ggcattggca aagccaaagc tgattgagcc acttgactac gaaaatgtca
      301 tcgtgcagaa gaagacccag atcctgaatg actgtctgcg ggagatgctc ctcttccctt
      361 acgatgactt ccagacggcc atcctgaggc ggcaggggcg ctacgtacgt tccacggtcc
      421 ctgcaaatgc agaggaggaa gcacagagcc tgtttgtcac cgagtgcatc aaaacctaca
      481 actctgactg gcaccttgtg acctatcact atgaagatta ctcaggagag ttccgacagc
      541 ttccaaacaa agtggccaag ttggataaac ttccagttca cgtctatgaa gtcgatgagg
      601 aggctgacaa agatgaggac gctgcttccc ttgggtctca gaagggtgga atcacaaagc
      661 acggctggct gtacaaaggc aacatgaaca gtgccatcag cgtgaccatg aggtcattca
      721 agaggcggtt tttccacctg attcagcttg gcgatggatc ctataatcta aacttttata
      781 aagatgagaa gatctccaag gagccgaaag ggtccatatt cctggattcc tgcatgggcg
      841 tgatccagaa caacagagtc aggcgcttcg cctttgagct caagatgcag gacaaaagca
      901 gttaccttct ggctgcggac agtgaggcag agatggagga gtgggtcaca gtcctcaaca
      961 agatcctcca gctcaacttt gaggctgcaa tgcaagagaa gcgaaatggg gaccctcatg
     1021 aagatgatga acaaagcaaa ctggaaggtt ccggttccgg tttggacagc tacctgcctg
     1081 aacttgccaa gagcaccaga gaagcagaaa tcaaactgaa aagcgagagc agagtgaagc
     1141 tcttttactt ggacccagat acccagaaac tcgacttctc atctgctgaa ccagaagtga
     1201 agccatttga agaaaagttt gggaagagga ttctcgtcaa gtgcaatgat ttgtccttca
     1261 acctgcagtg ctgtgtcgca gagaacgagg aaggacccac gacaaatgtg gagcctttct
     1321 ttgtcaccct gtccctgttc gacataaaat acaaccggaa gatttctgct gacttccacg
     1381 tggacctgaa ccacttctca gtgcggcaga tgctggcccc tgcatcccca gtgctgatga
     1441 acggtggtca gagtccacct gccttccagg atgcccttca ggcggccatg cagtatccga
     1501 agcagggaat attttcagtc acgtgtcctc acccagacat atttcttgtg gccagaattg
     1561 aaaaggtcct ccaaggaagc atcacgcact gtgctgagcc ttacatgaaa agctcagact
     1621 cttctaaggt cgctcagaag gtgctgaaga atgccaagca ggcatgtcaa agactaggac
     1681 agtaccgaat gccgtttgct tgggcagcaa ggacgttgtt taaagacaca tctggaaacc
     1741 tggataaaaa tgccaggttt tctgccatct accggcaaga cagcaataag ctctcaaatg
     1801 aggacatgct caagctgctc gcagacttcc ggaaacctga gaagatggcc aaactcccag
     1861 tgattttagg caatctagac attacaatcg acaacgtttc ctgcgacttc cctaattacc
     1921 tgaattcatc atacattccc atgaggcagt ttgaaacctg cagtaagtct ccgatcacct
     1981 tcgaagtaga ggagtttgtg ccctgcatac ccaagcacac ccagccttat acagtctaca
     2041 gcaatcacct ttatgtttac cccaagtact tgagatacga cagccagaag tcttttgcca
     2101 aggccagaaa cattgcaatc tgcattgagt tcaaggattc cgatgaagaa gactcgcaac
     2161 ccttgaagtg catttacggc agacctggtg gcccagtgtt cacaaggagt gccctcgctg
     2221 cagtcctaca ccatcaacaa agcccagaat tctacgatga gatcaagata gagctgcccg
     2281 cccagctgca cgagaagcac catttactgt tcaccttctt ccacgtcagc tgcgacaact
     2341 cgaccaaagg gagcacgaag aagaaggacg ctgtggagac acaggttggc ttctcctggc
     2401 ttcctctcct gaaagacggc agagtgttga cgaatgaaca gcatatccct gtctccgcca
     2461 acctgccgtc tggctacctt ggctaccagg agctcagcat gggcaggcat tatggtccag
     2521 aagttaagtg ggtggaagga ggcaagccat tgttgaaaat ctccactcat ctggtttcca
     2581 ccgtgtacac tcaggatcag cacttacaca attttttcca atactgtcag aaaacggaat
     2641 ctggagccca agcctcaggg agtgaactag tgaaatacct taagagtctg catgcaatgg
     2701 aaggtcacgt gatgatcgcc ttcctgccga ccattttaaa ccagctattc cgagtcctca
     2761 ccagagccac ccaggaggag gttgcagtta atgtgactcg ggtcattatt catgtggttg
     2821 cccagtgcca tgaggaagga ttggagagcc acttgaggtc atatgttaag tttgcctaca
     2881 aggctgagcc gtatatagca tccgagtata agacagtgca cgaggaactg acgaaatcca
     2941 tgaccaccat tctcaagcct tctgctgatt tccttaccag caacaaactt ctgaagtact
     3001 cttggttttt ctttgatgtg ctgataaagt ccatggctca gcatttgatt gaaaataaca
     3061 aagtgaagtt acttcgaaac cagagatttc cggcctccta ccatcacgcc gtggaaaccg
     3121 tggtgaacat gctgatgccg cacatcacac agaagtttcg agataaccca gaagcatcta
     3181 agaatgccaa tcacagcctg gccgtgttca tcaagagatg cttcaccttc atggacagag
     3241 gcttcgtctt caaacagatc aacaactaca tcagttgctt tgctcctgga gaccccaaga
     3301 ctctctttga gtacaagttt gagtttctcc gtgtggtgtg caaccatgaa cactatattc
     3361 ctttgaactt gccgatgcca tttgggaaag gaagaattca gagataccaa gatctccagc
     3421 ttgactactc tttaacggac gaattctgca gaaaccactt cttggtggga ctgttactaa
     3481 gggaggtggg tactgcactc caggagttcc gggaggtccg tgtcatcgct gtcagtgtgc
     3541 tcaagaacct tctgatcaag cattcttttg atgacagata cacttcaagg agtcaccagg
     3601 caaggatagc caccctctac ctgcctctgt ttggtctgct tattgaaaac gtccagcgga
     3661 tcaacgtgag ggatgtgtcg cccttccctg tgaacccggg cagtatctcg aaggacgaag
     3721 ccctggccgt gcctaccggg aatccactca tgactccgca gaagggaaac acacttgacc
     3781 acagcctgca caaagacctc ttgggtgcca tctccggcat tgcttctccg tatacagctt
     3841 caacccccaa catcaacagt gtgagaaatg ccgactcaag gggctctctc atcagcacgg
     3901 actcggggaa cagccttcca gacaggaacc ccgagaagag caactccctg gacaagcagc
     3961 agcagagcgg catgctggga aattctgtgg tccgctgtga caaactggac cagtctgaga
     4021 tcaagagcct gctgatgtgc ttcctctacg tgttgaagag catgtctgac gatgccctgt
     4081 ttacgtactg gaacaaggct tccactgctg aactgatgga tttctttacc atatctgaag
     4141 tgtgcctgca ccagttccag tacatgggga agcgctacat agccagtgtg agaaagatat
     4201 caagtgtgct tgggatttct gtagacaatg gctacggcca ctcggaggca gatgtcgctc
     4261 accagtcgct tctcgaagca aacatcgcca ctgaggtctg cctcacagct ctggacaccc
     4321 tctcgctgtt cacactggct tttaagaacc agctcctagc tgaccatgga cataatccac
     4381 tcatgaagaa agtttttgat gtctacctgt gtttcctcca aaagcatcag tcagaaatgg
     4441 ctttaaaaaa tgtcttcact gccttaaggt cattaattta taagttcccc tcaacgttct
     4501 acgaggggcg ggcagacatg tgcgcatctc tgtgctatga ggttctcaag tgctgtaact
     4561 ccaagctcag ctccatccgc accgaggcct cccagctgct ctacttcctg atgaggaaca
     4621 acttcgacta cacagggaag aagtcttttg tccggacaca cttacaggtc atcatctctg
     4681 tcagccagct gatcgcagac gtggttggca ttggaggaac cagattccag cagtccttgt
     4741 ctatcatcaa caactgtgcc aatagcgacc ggctcattaa gcacaccagc ttctcctctg
     4801 atgtgaagga tttgaccaag aggatccgca cagtcctgat ggccacagcc cagatgaagg
     4861 aacatgagaa cgacccagag atgctggtgg acctgcagta cagcctggcc aagtcctacg
     4921 ccagcacccc tgagctcagg aagacatggc tggacagcat ggcaaggatc catgttaaaa
     4981 atggggatct ctcagaggca gcaatgtgct atgtccacgt gacagctttg gtagcggaat
     5041 atctcacacg gaaagaagct gacctagcac tccagcggga accacctgtc ttcccctaca
     5101 gccatacctc ctgccagagg aagagccggg gaggcatgtt cagacagggg tgcacagcct
     5161 tcagggtcat cacaccaaac attgatgaag aggcttccat gatggaagat gtcggcatgc
     5221 aggatgtcca tttcaatgag gatgtgctga tggagctgct ggagcagtgc gcagatggac
     5281 tttggaaggc agagcgctac gagctgattg ctgacatcta taaactcatc atccccatct
     5341 atgaaaagcg gagggacttt gagagactag cccacctgta tgacacgctg caccgcgcat
     5401 acagcaaagt gacagaggtc atgcactcgg gccgcaggct cctggggacc tacttccggg
     5461 tggccttctt cggacaggga ttcttcgaag atgaagacgg gaaggaatac atctacaaag
     5521 agcccaaact cacgcctctg tcagagattt ctcagagact ccttaaactt tactcggata
     5581 aattcggttc tgaaaatgtc aaaatgatac aggattctgg caaggtcaac ccgaaggatc
     5641 tggattccaa gtttgcttac atccaggtga cccatgtgac cccgttcttt gatgaaaagg
     5701 agttacagga gaggaaaaca gagtttgaac gatgtcacaa catccggcgc ttcatgttcg
     5761 agatgccctt cacccagact gggaagaggc agggtggcgt ggaggagcag tgtaagcgac
     5821 ggaccatcct gacagcaata cactgcttcc cctatgtaaa gaagcggatc cctgtcatgt
     5881 accagcacca cactgacctg aaccccattg aggtggccat cgatgaaatg agcaagaaag
     5941 tggccgagct ccgccagctg tgttcctcag ctgaagtgga catgatcaaa ctgcagctca
     6001 aactgcaggg cagtgtgagc gtccaggtca atgctggccc gctagcatac gcccgagcct
     6061 tcctcgatga caccaacaca aagagatacc ctgacaataa ggtgaagctg ctgaaggaag
     6121 ttttcaggca attcgtggaa gcttgtggcc aagccttggc agtgaacgaa cgtctgatta
     6181 aagaggacca gctggagtac caggaagaga tgaaagccaa ctacagggag atggccaagg
     6241 agctctccga catcatgcgt gagcaaattt gccccctgga ggagaagaca agcgtgctac
     6301 caaattccct gcacatcttc aacgccatca gtgggacacc aacaagcaca gtggttcaag
     6361 ggttgaccag ttcatcctca gttgtgtgac tttacctcat gaaccacacg tggggacatg
     6421 ctttgtcatg tgcaaactca ggacgacttt cagagctaat cactggtttt gccaagcaca
     6481 ggaagaagcc atggggaatg ggagagagaa agagcctgga ctgtgatatt taatagcaga
     6541 ttttatagga gttgggggaa ggtgcacata tttttttaaa tatcactggc aatgtttagt
     6601 tttcctcatg tcttaacagg tgtatgtgga tactcttggg ctgcagttca attttattct
     6661 tcttacagta tagtattaaa ataaatggtc taaaggaaaa gagggaaagt atgctgggac
     6721 acctgtagca ggtgtgctgg gacacctgta ccagctgtgc tgggacacct gtaccagctg
     6781 tgctgggaca cctgtagcag atgcagcagc actgaacctg ggaatgggga ctaagctgga
     6841 aaaatcttga aaatattttt ctccctgtgg cacattcagg ttgagtacaa gaactatttt
     6901 tgtgtctagt tttgaagact gaagggaatt gactattgag attttttact agtgaatgcg
     6961 gagacttaga gcctttatat ccatgccttg tgttgacaac atgagcactt ccgaagctga
     7021 gtgtgatgtg agcctaagcc tagtcagcag catagaacca aaggcctgca ctagcgaaca
     7081 cacctatgct aaaacctaaa accccatgta catatgttct gttaatacgg cctcctcgct
     7141 gagtccacgt acttactaca tttctacact tttaatacat cagtgtccgt gttaagttta
     7201 ttattcgtga cccatttgtg ctgttctcgg tatatgcaaa tacattggac ttcactgttt
     7261 attcttgtac ataagaagtg caatatggag atgtatacag tctttgctat gttaggttta
     7321 taaactgttt ttaaaaagaa attcatcctt ttgccaaaat ggtggagtat gtgattggta
     7381 aaccctaaac cctgtggtga gtggagggat aatttaaagt tttcaccatg ttatattttc
     7441 ttttaagact ttaatttagt aattttatat ttgggaaaat aaaggttttt aatttaactg
     7501 gaatcactgc cctgctgtaa ttacatatcg tgtaccccaa ctgtattaaa aataacactg
     7561 ctgattttct ggtaataaa
//
LOCUS       NM_001437979            1637 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            8, mRNA.
ACCESSION   NM_001437979 XM_039079167
VERSION     NM_001437979.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039079167.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1380905.1,
                                           SRR26360181.2625084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-75               JAXUCZ010000007.1  97509567-97509596
            76-220              JAXUCZ010000007.1  97509983-97510127
            221-444             JAXUCZ010000007.1  97510643-97510866
            445-631             JAXUCZ010000007.1  97512128-97512314
            632-806             JAXUCZ010000007.1  97512838-97513012
            807-912             JAXUCZ010000007.1  97515701-97515806
            913-960             JAXUCZ010000007.1  97516474-97516521
            961-1136            JAXUCZ010000007.1  97517084-97517259
            1137-1278           JAXUCZ010000007.1  97517640-97517781
            1279-1352           JAXUCZ010000007.1  97518224-97518297
            1353-1637           JAXUCZ010000007.1  97519504-97519788
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1637
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..75
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            76..220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    177..179
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            221..444
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1607
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 2 is encoded by transcript variant 8;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 2"
                     /protein_id="NP_001424908.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELAQELCKSICDMLTRVL
                     LLYGGKVRPQGEVALQGNTGQAVLPCVSCIGLLRSICHMTKQNKLLRFQPIVPMTIQC
                     QSMGSSQLNK"
     misc_feature    234..938
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    234..938
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    996..>1364
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    996..>1364
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            445..631
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            632..806
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            807..912
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1136
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1278
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1352
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1637
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgaggtccc aggagggcga
       61 tgcttgagga cccagacagg tgaatcccag agcccacctc agggaggtcc tggcttcaat
      121 gtcaagaaaa ccatgataca acgcaactgg agataagagg aaactggagt ccaccttagg
      181 tccttccgca caggaatttg tacaaccaca gggaaagcaa gagcatgtca tctctgttct
      241 tgaggagcac caaaagcctg gtgagagagc tgggcaggaa gggtgagctg gtgccggtag
      301 acagcctgaa cagttcacag cgcctgcgcc ccttctgcct ggtgaggaag aagcacaagc
      361 attccctctg gccttgggac acacccctca tccccacaga cttctccctg ctggatgtgc
      421 tggagcctgg ctgccctgac ccagaggtga accacagcaa gcccatctat tcctgggaga
      481 aggaggcaga gggattgaca ggagctgtga gcgtgagtgc tgggctgcag agccaggtga
      541 ctggaagcgg cacgaccacc tgcctctctg ccttggcggt gcagacactc tgggtctccc
      601 cgtttacctg ggagatgctt cttgagaaaa ggaaactgag gtcgcctagg ccctcgttcc
      661 tccaggaact acagagccgg aaggagaggg agagcctata tgtggtgacc gaggctgtgg
      721 agaccctgca agataccata cttcagagcc acgaccaaat gcgaggagcc ggacagctgt
      781 ccctcctaca gctgggccat gttcaggtcc agggacagag ccatgtggac acagagaaga
      841 tggtgagcat cccacagggc agtgttctgg cctacagggt tctgcagcta gtggtggaag
      901 aagatggctg ggctgtcctt tacttccctg aaagaaagct ctgcaggaat gccagagtag
      961 ctatagcctt cagccaggaa tcaggagaag agtctaactt ctacagcttg cgggaccaag
     1021 cagatagcca gttgcaggac ctggtcacat tatcctcaga gcgacgggcc acattgcttg
     1081 gtgccctcca ggagctacta cgggatcagc aggcactcca ggagctagag gatacgctgg
     1141 aacaggctct ggacacaggg ctgctggcac agctggaggg ccctggaggc tgtgtcttat
     1201 gcatcctcca agactctaca agcaacttgt catgctcgaa aggcagggct atcctctata
     1261 ttcttggagc cttagcagca ctgagtgaac cccagcattg cctgctggcc cagtccatag
     1321 agagacaaat cctatctgag gaactggagc tggcacaaga actttgtaaa agtatatgtg
     1381 acatgcttac aagagtgctg ttattgtatg gtggcaaggt gagaccacag ggagaagtag
     1441 ctcttcaggg taacacagga caagctgtcc tgccttgcgt ttcctgcatt ggcctccttc
     1501 gttccatctg tcacatgaca aaacagaaca agctgctcag gttccagccc attgtaccaa
     1561 tgactataca atgtcagagc atgggatcga gtcagttgaa taaataagac caggctcttc
     1621 ccagtcttcc ttgttaa
//
LOCUS       NM_001437910            3979 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 4, mRNA.
ACCESSION   NM_001437910 XM_063282148
VERSION     NM_001437910.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3979)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3979)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 3979)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063282148.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.6740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000002.1  177791620-177791637 c
            19-148              JAXUCZ010000002.1  177786942-177787071 c
            149-226             JAXUCZ010000002.1  177784108-177784185 c
            227-337             JAXUCZ010000002.1  177782701-177782811 c
            338-506             JAXUCZ010000002.1  177779310-177779478 c
            507-602             JAXUCZ010000002.1  177778834-177778929 c
            603-648             JAXUCZ010000002.1  177775282-177775327 c
            649-761             JAXUCZ010000002.1  177774722-177774834 c
            762-836             JAXUCZ010000002.1  177771722-177771796 c
            837-889             JAXUCZ010000002.1  177768704-177768756 c
            890-975             JAXUCZ010000002.1  177766872-177766957 c
            976-1147            JAXUCZ010000002.1  177765163-177765334 c
            1148-1346           JAXUCZ010000002.1  177760418-177760616 c
            1347-1624           JAXUCZ010000002.1  177758391-177758668 c
            1625-1797           JAXUCZ010000002.1  177758048-177758220 c
            1798-1987           JAXUCZ010000002.1  177756072-177756261 c
            1988-2042           JAXUCZ010000002.1  177755325-177755379 c
            2043-2217           JAXUCZ010000002.1  177753749-177753923 c
            2218-2290           JAXUCZ010000002.1  177753274-177753346 c
            2291-2486           JAXUCZ010000002.1  177751968-177752163 c
            2487-2575           JAXUCZ010000002.1  177751792-177751880 c
            2576-2629           JAXUCZ010000002.1  177749533-177749586 c
            2630-2711           JAXUCZ010000002.1  177747255-177747336 c
            2712-2929           JAXUCZ010000002.1  177746302-177746519 c
            2930-3035           JAXUCZ010000002.1  177745433-177745538 c
            3036-3103           JAXUCZ010000002.1  177740434-177740501 c
            3104-3298           JAXUCZ010000002.1  177739078-177739272 c
            3299-3979           JAXUCZ010000002.1  177736374-177737054 c
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3979
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..18
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            19..148
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             59..3337
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 4"
                     /protein_id="NP_001424839.1"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGT
                     KSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGSSS
                     GNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGMIHPGAWRTATEEWGTEDWNE
                     DLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPS
                     LAQPLVFSNSKQNAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFK
                     TAQALAQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFT
                     PSSTMMEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQ
                     KLKQQKKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYESTPTTSAS
                     SSQAPSSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQT
                     RRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSESPSTSSIPSLN
                     ETVPAASLLTTASQHSSSLSGLSHSEEIPNTTTTQHSSALSTQQNTLSSSTSSGRTST
                     STLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVT
                     ASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFP
                     LDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQT
                     HHTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSV
                     NASATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQSFEKQGFHSGTPAAS
                     FNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQDILTLVDD
                     QLGE"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1619..1702
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1619..1702
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            149..226
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..337
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..506
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..602
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..648
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..761
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..836
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..889
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..975
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1147
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1346
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1624
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1797
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1987
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2042
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2217
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2290
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2486
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2575
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2629
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2711
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2929
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3035
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3103
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3298
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3979
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgagta ttcttccttg taaatactgt tatttgtata tactgtaaat
       61 gatgacgtcg gtgggcacta accgagcccg gggaaactgg gaacaacctc aaaaccaaaa
      121 ccagacacag cacaagcagc ggccacaggc cactgcagag caaattcgac ttgcacagat
      181 gatttcggac cataatgatg ctgactttga ggagaaggtg aaacaattga ttgatatcac
      241 aggcaaaaac caggatgaat gtgtgattgc tttgcatgac tgcaatggag atgtcaacag
      301 agccatcaat gttctcctgg aaggaaatcc agacacgcat tcctgggaga tggtcgggaa
      361 gaagaaagga gtctcaggac agaaggatgg tggacaaact gaatctaatg aagaaggaaa
      421 agaaaatcga gaccgggaca gagactatag tcgacgacgt ggtgggccac caagacgggg
      481 gagaggtgcc agccgtggac gagagtttcg gggccaggaa aatggattgg atggcactaa
      541 gagtggtgga ccttctggaa gaggcacaga cagagggaga agaggccgtg gccggggcag
      601 aggtagttct ggtagacgag gaggaaggtt ttctgctcaa ggaatgggaa cctttaaccc
      661 tgctgattat gcagagccag ccaacactga tgataactat ggcagtagca gtggcaatac
      721 atggaacaac actggccact ttgaaccaga tgatggaaca agacttgatt tcattggggt
      781 tgaggggtca aattatcccc gaaaatttga gactgctcct ggtatgatac atccaggtgc
      841 atggaggact gcaacagaag agtggggaac tgaagattgg aatgaagatc tttctgagac
      901 caagatcttt actgcctcta atgtgtcttc agtgcctctg cctgcggaga atgtgacaat
      961 cactgctggt cagagaattg atcttgctgt tctgttgggg aagacaccgt cttcaatgga
     1021 gaatgattca tctaatctgg atccatctca ggctccttcc ctggcccagc ctctggtatt
     1081 cagtaattcg aagcagaatg ccatatcaca gcctgcttca gggaatacat tttctcatca
     1141 tagcatggtg agcatgttgg ggaaaggatt tggtgatgtt ggggaagcta aaggtggcag
     1201 tacaacaggc tctcagttct tggagcaatt caagactgca caggccctgg ctcaactggc
     1261 agctcaacat tctcagtctg gaagcaccac cacctcctct tgggatatgg gctcaacaac
     1321 acaatcacca tcactggtgc agtatgattt gaagagtgca aatgattcaa cagtgcacag
     1381 tccttttaca aagcgccagg cattcacccc atcatcaacc atgatggagg tgttccttca
     1441 ggagaagcca cctgcagtgg ctacctcgac agctgcacct cctcccccct cttctcctct
     1501 gccaagcaaa tccacctcgg ctccacagat gtctccgggg tcttcggaca accaatcctc
     1561 cagccctcag ccggctcaac agaaactgaa acagcaaaag aagaaaacct ccttgacgtc
     1621 taagattcct gctctggctg tggagatgcc tggctcagca gatatctcag ggctaaatct
     1681 gcagtttggg gcattgcaat ttgggtcaga gcctgtcctt tctgattatg agtccacccc
     1741 caccacgagc gcctcttcaa gccaggctcc cagtagcctg tataccagca cggccagtga
     1801 gtcttcatct acagtttcat ctaatcagag tcaggagtct ggttatcaga gtggcccaat
     1861 tcagtcgaca acttatacct cccaaaataa tgctcagggc cctctatatg aacagagatc
     1921 cacacagaca cggcggtatc ccagctccat ctcttcatca ccccaaaagg acctgactca
     1981 ggctaagaat ggtttcagct ctgtgcaggc cacgcagtta cagaccacgc aatctgttga
     2041 aggtgctaca ggctctgcag tgaaatctga atcaccttcc acttctagta taccctctct
     2101 caatgaaaca gtacctgcag cttccttact gacgacagcc agtcagcatt catcctcctt
     2161 aagtggcttg agccatagtg aggagattcc aaataccacc accacacaac atagcagtgc
     2221 attatctaca cagcagaata ccctttcttc atcaacatct tctgggcgta cttcaacatc
     2281 tactcttttg catacaagtg tggagagtga agcgaatctg cattcttcct ccagcacttt
     2341 ctctaccacg tccagcactg tctctgcacc tcccccagtg gtcagtgtct cctccagtct
     2401 gaatagtggc agtagcctgg gccttagcct gggcagcaac tctactgtca cagcctcaac
     2461 tcgaagctca gttgctacaa cttcaggaaa agctcctccc aaccttcctc ctggagtccc
     2521 gccattgttg cctaatccat atattatggc tccagggctg ttacatgcct acccgccaca
     2581 agtatatggt tatgatgatt tacagatgct ccagacaaga tttccattgg attactacag
     2641 tatcccgttt cccacaccca ccactccact tactgggagg gatggtagcc tggccagcaa
     2701 cccttactct ggcgacctca ccaagttcgg ccgcggggat gcctcctccc cagccccagc
     2761 cacaaccttg gcccaacccc aacagaacca gacgcagact caccacacca cgcagcagac
     2821 attcctgaac ccggcgctgc ctcctggcta tagttacacc agcctgccat actacacagg
     2881 ggtcccgggc ctccccagca ccttccagta tgggcctgct gtgttccctg tggctcctac
     2941 ctcttccaag cagcatggtg tgaatgtcag tgtgaatgcc tcggccaccc ctttccaaca
     3001 accaagtgga tatgggtctc atggatacaa cactggtgtg tcagtcacct ccagtaacac
     3061 gggcgtgcca gatatctcgg gttctgtgta ctccaaaacc cagtcctttg agaaacaagg
     3121 ttttcattcc ggtactcctg ctgcctcctt caacttgcct tcagccctag gaagtggagg
     3181 gcccatcaat ccagccacag ctgctgccta cccacctgcc ccctttatgc acattctgac
     3241 cccacatcag cagccacact ctcagatcct tcaccatcac ctgcagcagg atggccagga
     3301 tatcctcact ctcgtcgatg accagcttgg tgaataagta ttaccgtacc aactgggcct
     3361 cttctagcag gctcgaaggc tgtggaataa agtgaaatct ttgcccttta agaactctca
     3421 ccttaatgtg ctaatatttt gcccttaagg ggattccctt ttacatcctg tgactgaaaa
     3481 gaaccactgc acatcttcat ttcttctaga aactgcctca cctacagcaa gtttcaggaa
     3541 gtgaaagggg aaggagctaa ggacatttaa aaggaaaagg accttgtggg aatctaagca
     3601 tgatttaaag gattctgaaa tctgaagcca gcattatcta ctgtctggca gaaccaaatt
     3661 gtagggcttt tttctttttg gaggagtata gtagttcttg tctgagttat gtttttgaga
     3721 caatctcact atgtaaccct gactggctag aagttgtaac ccaactggct ggaagttggt
     3781 gtggagacca ggctggtctc aaattcagag atctacctgc ctctacctct tgagtgccaa
     3841 ggttaaaggt tctcagcact ataccttacc ttgccttttt tatgtgactt tgaaatgcct
     3901 aagttttggg aaaggagtgg atgatggtag agcaagacct ggggtgggga catggtgcag
     3961 taaaaggttt tggacatgg
//
LOCUS       NM_001437898            4356 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 7, mRNA.
ACCESSION   NM_001437898 XM_063263337
VERSION     NM_001437898.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4356)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.26751.1,
                                           SRR26643295.29802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-312             JAXUCZ010000007.1  122187562-122187662
            313-440             JAXUCZ010000007.1  122193494-122193621
            441-596             JAXUCZ010000007.1  122194723-122194878
            597-679             JAXUCZ010000007.1  122198007-122198089
            680-727             JAXUCZ010000007.1  122198472-122198519
            728-970             JAXUCZ010000007.1  122203808-122204050
            971-1157            JAXUCZ010000007.1  122207498-122207684
            1158-1295           JAXUCZ010000007.1  122210547-122210684
            1296-1361           JAXUCZ010000007.1  122213276-122213341
            1362-1474           JAXUCZ010000007.1  122216165-122216277
            1475-1588           JAXUCZ010000007.1  122216625-122216738
            1589-1715           JAXUCZ010000007.1  122218925-122219051
            1716-1868           JAXUCZ010000007.1  122220112-122220264
            1869-2084           JAXUCZ010000007.1  122223641-122223856
            2085-2149           JAXUCZ010000007.1  122225088-122225152
            2150-2265           JAXUCZ010000007.1  122226909-122227024
            2266-2351           JAXUCZ010000007.1  122228286-122228371
            2352-2449           JAXUCZ010000007.1  122229298-122229395
            2450-2507           JAXUCZ010000007.1  122229728-122229785
            2508-2629           JAXUCZ010000007.1  122230077-122230198
            2630-2793           JAXUCZ010000007.1  122230444-122230607
            2794-2950           JAXUCZ010000007.1  122231523-122231679
            2951-3039           JAXUCZ010000007.1  122231770-122231858
            3040-3235           JAXUCZ010000007.1  122232571-122232766
            3236-3463           JAXUCZ010000007.1  122235416-122235643
            3464-4356           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4356
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..312
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..440
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..596
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..679
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    657..659
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            680..727
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..970
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..3512
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 2 is encoded by transcript variant 7;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 2"
                     /protein_id="NP_001424827.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLAFSEYQIQQMTANFVDQFGFNDEEFADQDD
                     NINAPFDRIAEINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARV
                     MARARFGAPHTSENYSKKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDS
                     AGTTWTAVFDEPVNPLSAASGAARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETG
                     PRCSSPVDMDHSNAEGGQSPGPEKAFGPTSPCAWNVCVTRKAPLVASDSSSSGGSDSE
                     DDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRAECPDSTVLAPACPAPSEVTISPAV
                     ATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAIVATLGTMTKDRKTDALPD
                     GAALNGPV"
     misc_feature    1125..2345
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    1125..2345
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2595..>3482
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2595..>3482
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            971..1157
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1295
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1361
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1474
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1588
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1715
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1868
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2084
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2149
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2265
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2351
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2449
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2507
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2629
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2793
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2950
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3039
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3235
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3463
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..4356
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggttctcagc cttggctgtc ctggaactct
      241 ctccatagac caggcgggcc ttgaactcat agagatctgc ctacctctgc ctcctgagtg
      301 ctgagatcaa aggtaaacca accaaaactc tttgcagaat gaaaacacct tttttaaaat
      361 tgcatgtata caaaagaaag agcccaaatg ctttttattt tgcctgaata caagatttaa
      421 acaaggtatt gccatagaag tctctaccac agcgcgttct gttggactct ttcacggaac
      481 tataggatca catgggcagc acttgtgttt gattctaccc tctttcttcc ggtcggttct
      541 gtcaccctgg gaaatagaga agcagaacgt acggctcctt tcttcattca ctgctggatc
      601 aatgtccagg gccaaggcag ttttgtttgt gtggatttct gtttactgct gcatggtaga
      661 ggctgccgaa ccccataagg aaacattgtt gcggtttgca catccagtct gagagacttc
      721 tgcattgctc tgtgaccacc atcatgttct ggaaatttga cttgaatacc acgtcccacg
      781 ttgacaagct cctcgacaag gaacatgtga cactgcagga attaatggat gaagatgaca
      841 tcttgcaaga gtgtaaggct cagaaccaga agctgctgga cttcctgtgc aggcagcagt
      901 gtatggagga gctggtgaac ctcatcacac aagacccacc ccaggacatg gaagagaagg
      961 tccgattcaa atatccaaac acagcctgtg agcttctgac ttgtgatgtg ccgcagatca
     1021 gcgacagact aggcgaggac gagagtctgc tgaaccttct gtatgacttc ttggaccagg
     1081 agccaccact caaccctctg cttgccagtt tttttagcaa gaccattggc aatctcattg
     1141 caaggaaaac cgaacaggtg atcatgttct tgaagaagaa ggacaagttc atcagtctga
     1201 tactgaagca cataggcacc tcagctctca tggacctgct gctacgcctg gtcagctgcg
     1261 tggaaccagt tgttctccgg caggaggtcc tacattggct taatgaagag aaagtcatcc
     1321 agagacttgt ggaattgatc catccccacc aggatgaaga taggcagtca aatgcttctc
     1381 aggcactctg tgacatcatc aggctgggca gagaccaggg cagtcagctg caggagactg
     1441 tggagccgga tcccctcctc acagcactgg agtcgcagga ctgtgtggaa cagcttctga
     1501 agaacatgtt tgatggggat cggacggaga gctgcctggt cagtgggatg caggtgctgc
     1561 ttgccctgct ggagccaagg cgtgttggaa cagaaggctt ggtggactcc ttttctcagg
     1621 gactggaaag gtcatactct gtcagcagca gcatcctgca cggcattgag ccatggctga
     1681 agaatttcca tcagctcctg ctcaacccac caaagaagaa agcaatcctg accactattg
     1741 gcgtgctaga ggagcccctg gggaatgctc gtcttcatgg tgcacgcctc atggctgcac
     1801 tgctgcacac aaatacgccc agcatcaacc aggagctctg ccggctcaac accatggact
     1861 tactgctgga cctgtttttt aagtacacct ggaataactt cttacacttg caagtggagc
     1921 tgtgcatagc cgctattctc tcccacgctg gtcgggagga gcaggcagaa gctggcagat
     1981 cagatggcaa agtggaacct gtgcagggga gtggagatgg gggtgggaag ccggagacca
     2041 ccccgtccat caccagccct cctgagaaca caatggtgac ccatctgttc cagaagtgct
     2101 gcctggttca gaggatcctg gaagcctggg aagccaatga caacacacag gcggcaggtg
     2161 gcatgagacg tgggaatatg ggccacctca caaggatcgc caacgcagtt gtacagaacc
     2221 tggagcaggg cccggtgcag acacacatca gtgaagtcat ccgagggctc cctgcagagt
     2281 gccgtggacg ctgggagagc tttgtggaag agacactgat ggagaccaac cgcaggaaca
     2341 ctgtggacct ggccttctct gagtaccaga tccagcagat gacagcaaac tttgtggatc
     2401 agtttggctt caatgatgag gagtttgcag accaggatga caacatcaat gccccatttg
     2461 accggattgc agagatcaac ttcaacattg aagccgatga ggacagtccc agtgcagctc
     2521 tgtttgaagc ttgctgcagt gatcggatcc agcccttcga tgatgacgag gaggacattt
     2581 gggaggatga ggagactcga tgcacggccc gggtgatggc cagagccagg tttggagccc
     2641 ctcacacctc agaaaactac tcaaagaagg ccgtgggaca tggaggccag ggcaggaaga
     2701 ctggctcccc cacagctagg aatgtgcctg gactggccac gccttcatcc cctacacaga
     2761 aagaaggtcc tcgctcagaa agtgattcag caggtactac atggacagca gtttttgatg
     2821 agccagtgaa cccgctgtct gcagcctcag gagctgcgag ggatgtgggt tctagtgcat
     2881 gggcggctgg tccttcagtt gcagaggaga aaggctgggc caaattcacc gacttccagc
     2941 ctttctgctg ctctgagaca gggccccggt gcagctctcc tgtggacatg gaccacagca
     3001 atgccgaggg tggccagagt ccaggcccag agaaagcctt tggtcctacc tcgccttgtg
     3061 cctggaacgt gtgtgtcact aggaaggccc cactggtagc ctctgacagc agctcctctg
     3121 ggggatctga cagtgaagat gacgagaagg cagcgggtgc tgtggaagct ctgtgcgcag
     3181 gccatactgg aaaggcctcc ccgccaccca ggacagcaga ggctgctgct ggcagggccg
     3241 agtgtcctga cagcaccgtg ttagcccctg cctgccctgc tccttcagaa gtgaccatca
     3301 gtcctgccgt ggctaccata gcaccaagca aggcaggctc tcccacagcc accatagtgg
     3361 tctcttcctc agtggctact gcggtacccc caggaccaat catggcagta accacaacag
     3421 ctccagccat agttgcaacc ctggggacaa tgacaaagga caggaagaca gatgccctgc
     3481 cagatggagc tgccttaaat ggccctgtgt aatggctgcc gcccagctat ggcccaccct
     3541 ggtcaggctg cctccttaat caagaagact acctggtgat gcaatttttt ttaatttaac
     3601 tttaaaataa atgctgcatt tggtaaagct ggcagtggaa cccgttggat gacccagctc
     3661 atgtttctcc tgcctgccct tggtcctgtt ggaggacagg atgcacctgg ccattcccag
     3721 gcccaggtct tggtgtggca atgcagccct gacgcgcagc ttcaacctgc aggagttggg
     3781 gagggaacaa gaccctaagg ggccagcacc atcggatggg caggaagggt gcggatctcc
     3841 aggcgctggt ttcatctgta tttttaacgc atggaggaaa agccgttttt tgcactttgt
     3901 acccagctac agtacagggt ctctctaggc tcagggcaga tgtacaggcc tgagttggag
     3961 agacctgatc cccactaata atactacatg ggggtctggc actagtttgg ccacatgagg
     4021 tcaaacccca gttctagctg cccagggact cctgggagct ggtgttgaat caggctacac
     4081 attttgactg ccttaaaaac aaagaccctc tggacccggt gcagtggtct ctgtgctcag
     4141 cagggcagac tggcacactc gggtgggggt tggagctgca ccagacatgt aagagtggac
     4201 acggaagagc actgggaggc ctagggaccg ggcgggccca tagtgtccag gaagagtcta
     4261 aagtctatgt tgtctttttt tttttttttt tttaaatgtt ctgaccttct gacagggcat
     4321 ctaaccccca ataaaaagga tcattcttac tgaaaa
//
LOCUS       NM_001437976            2210 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            4, mRNA.
ACCESSION   NM_001437976 XM_063263518
VERSION     NM_001437976.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263518.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.41286.1,
                                           SRR26360181.2388047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-75               JAXUCZ010000007.1  97509567-97509596
            76-220              JAXUCZ010000007.1  97509983-97510127
            221-444             JAXUCZ010000007.1  97510643-97510866
            445-631             JAXUCZ010000007.1  97512128-97512314
            632-806             JAXUCZ010000007.1  97512838-97513012
            807-912             JAXUCZ010000007.1  97515701-97515806
            913-960             JAXUCZ010000007.1  97516474-97516521
            961-1136            JAXUCZ010000007.1  97517084-97517259
            1137-1278           JAXUCZ010000007.1  97517640-97517781
            1279-1352           JAXUCZ010000007.1  97518224-97518297
            1353-2210           JAXUCZ010000007.1  97518931-97519788
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2210
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..75
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            76..220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    177..179
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            221..444
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1643
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 1 is encoded by transcript variant 4;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 1"
                     /protein_id="NP_001424905.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELVASILEHNCNQTEETT
                     SPLPTGVLCALKSEDEVLILNLVQGCGLELEKSGCQLPWDPTVVPQLSALYACLTGLQ
                     LLTDPSPGLSRTVPEEETLICP"
     misc_feature    234..938
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    234..938
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    996..1508
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    996..1508
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            445..631
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            632..806
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            807..912
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1136
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1278
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1352
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2210
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgaggtccc aggagggcga
       61 tgcttgagga cccagacagg tgaatcccag agcccacctc agggaggtcc tggcttcaat
      121 gtcaagaaaa ccatgataca acgcaactgg agataagagg aaactggagt ccaccttagg
      181 tccttccgca caggaatttg tacaaccaca gggaaagcaa gagcatgtca tctctgttct
      241 tgaggagcac caaaagcctg gtgagagagc tgggcaggaa gggtgagctg gtgccggtag
      301 acagcctgaa cagttcacag cgcctgcgcc ccttctgcct ggtgaggaag aagcacaagc
      361 attccctctg gccttgggac acacccctca tccccacaga cttctccctg ctggatgtgc
      421 tggagcctgg ctgccctgac ccagaggtga accacagcaa gcccatctat tcctgggaga
      481 aggaggcaga gggattgaca ggagctgtga gcgtgagtgc tgggctgcag agccaggtga
      541 ctggaagcgg cacgaccacc tgcctctctg ccttggcggt gcagacactc tgggtctccc
      601 cgtttacctg ggagatgctt cttgagaaaa ggaaactgag gtcgcctagg ccctcgttcc
      661 tccaggaact acagagccgg aaggagaggg agagcctata tgtggtgacc gaggctgtgg
      721 agaccctgca agataccata cttcagagcc acgaccaaat gcgaggagcc ggacagctgt
      781 ccctcctaca gctgggccat gttcaggtcc agggacagag ccatgtggac acagagaaga
      841 tggtgagcat cccacagggc agtgttctgg cctacagggt tctgcagcta gtggtggaag
      901 aagatggctg ggctgtcctt tacttccctg aaagaaagct ctgcaggaat gccagagtag
      961 ctatagcctt cagccaggaa tcaggagaag agtctaactt ctacagcttg cgggaccaag
     1021 cagatagcca gttgcaggac ctggtcacat tatcctcaga gcgacgggcc acattgcttg
     1081 gtgccctcca ggagctacta cgggatcagc aggcactcca ggagctagag gatacgctgg
     1141 aacaggctct ggacacaggg ctgctggcac agctggaggg ccctggaggc tgtgtcttat
     1201 gcatcctcca agactctaca agcaacttgt catgctcgaa aggcagggct atcctctata
     1261 ttcttggagc cttagcagca ctgagtgaac cccagcattg cctgctggcc cagtccatag
     1321 agagacaaat cctatctgag gaactggagc tggtggcaag catcttggag cacaactgta
     1381 atcagacgga ggaaacaacc tctcccctcc caacaggagt actctgtgcc ctgaagagtg
     1441 aggatgaggt cctcatccta aacctggtgc agggctgtgg gctagagcta gagaagtctg
     1501 gctgccagct cccctgggac cctacagtgg tacctcagct ttctgcactc tatgcatgcc
     1561 tcacagggct gcagctactg actgacccaa gccctgggct ttctaggaca gtgcctgaag
     1621 aggaaacact tatctgtccc taaggtctca tccaacctga ctcctggcag cctgggatgt
     1681 cactaaccct ctctagtggt cacagctgat gacagggttt caccaggaaa ggccccacac
     1741 tacacttaag actggttcca gacatcggaa acacctattc agaacaagta tcctgaatca
     1801 ggattctgtc tgagcagtgc aggctggctg cagaacagtt tggctgtgta tcttaggtag
     1861 catagtcccc tctgtactca ggtaaaatca gccattgtaa aatgagattt gtggtcattc
     1921 cccaggcaca agaactttgt aaaagtatat gtgacatgct tacaagagtg ctgttattgt
     1981 atggtggcaa ggtgagacca cagggagaag tagctcttca gggtaacaca ggacaagctg
     2041 tcctgccttg cgtttcctgc attggcctcc ttcgttccat ctgtcacatg acaaaacaga
     2101 acaagctgct caggttccag cccattgtac caatgactat acaatgtcag agcatgggat
     2161 cgagtcagtt gaataaataa gaccaggctc ttcccagtct tccttgttaa
//
LOCUS       NM_001437978            1711 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            7, mRNA.
ACCESSION   NM_001437978 XM_006241642
VERSION     NM_001437978.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006241642.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.127880.1,
                                           SRR26643293.41292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-75               JAXUCZ010000007.1  97509567-97509596
            76-220              JAXUCZ010000007.1  97509983-97510127
            221-518             JAXUCZ010000007.1  97510569-97510866
            519-705             JAXUCZ010000007.1  97512128-97512314
            706-880             JAXUCZ010000007.1  97512838-97513012
            881-986             JAXUCZ010000007.1  97515701-97515806
            987-1034            JAXUCZ010000007.1  97516474-97516521
            1035-1210           JAXUCZ010000007.1  97517084-97517259
            1211-1352           JAXUCZ010000007.1  97517640-97517781
            1353-1426           JAXUCZ010000007.1  97518224-97518297
            1427-1711           JAXUCZ010000007.1  97519504-97519788
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1711
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..75
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            76..220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            221..518
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1681
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 2 is encoded by transcript variant 7;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 2"
                     /protein_id="NP_001424907.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELAQELCKSICDMLTRVL
                     LLYGGKVRPQGEVALQGNTGQAVLPCVSCIGLLRSICHMTKQNKLLRFQPIVPMTIQC
                     QSMGSSQLNK"
     misc_feature    308..1012
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    308..1012
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    1070..>1438
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    1070..>1438
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            519..705
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            706..880
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            881..986
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1034
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1210
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1352
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1426
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1711
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgaggtccc aggagggcga
       61 tgcttgagga cccagacagg tgaatcccag agcccacctc agggaggtcc tggcttcaat
      121 gtcaagaaaa ccatgataca acgcaactgg agataagagg aaactggagt ccaccttagg
      181 tccttccgca caggaatttg tacaaccaca gggaaagcaa atcaggccag cttgcagcta
      241 tcacgaaggg atcccatatc cagcccggga tgatattgtc ccttgcctct caaggagcat
      301 gtcatctctg ttcttgagga gcaccaaaag cctggtgaga gagctgggca ggaagggtga
      361 gctggtgccg gtagacagcc tgaacagttc acagcgcctg cgccccttct gcctggtgag
      421 gaagaagcac aagcattccc tctggccttg ggacacaccc ctcatcccca cagacttctc
      481 cctgctggat gtgctggagc ctggctgccc tgacccagag gtgaaccaca gcaagcccat
      541 ctattcctgg gagaaggagg cagagggatt gacaggagct gtgagcgtga gtgctgggct
      601 gcagagccag gtgactggaa gcggcacgac cacctgcctc tctgccttgg cggtgcagac
      661 actctgggtc tccccgttta cctgggagat gcttcttgag aaaaggaaac tgaggtcgcc
      721 taggccctcg ttcctccagg aactacagag ccggaaggag agggagagcc tatatgtggt
      781 gaccgaggct gtggagaccc tgcaagatac catacttcag agccacgacc aaatgcgagg
      841 agccggacag ctgtccctcc tacagctggg ccatgttcag gtccagggac agagccatgt
      901 ggacacagag aagatggtga gcatcccaca gggcagtgtt ctggcctaca gggttctgca
      961 gctagtggtg gaagaagatg gctgggctgt cctttacttc cctgaaagaa agctctgcag
     1021 gaatgccaga gtagctatag ccttcagcca ggaatcagga gaagagtcta acttctacag
     1081 cttgcgggac caagcagata gccagttgca ggacctggtc acattatcct cagagcgacg
     1141 ggccacattg cttggtgccc tccaggagct actacgggat cagcaggcac tccaggagct
     1201 agaggatacg ctggaacagg ctctggacac agggctgctg gcacagctgg agggccctgg
     1261 aggctgtgtc ttatgcatcc tccaagactc tacaagcaac ttgtcatgct cgaaaggcag
     1321 ggctatcctc tatattcttg gagccttagc agcactgagt gaaccccagc attgcctgct
     1381 ggcccagtcc atagagagac aaatcctatc tgaggaactg gagctggcac aagaactttg
     1441 taaaagtata tgtgacatgc ttacaagagt gctgttattg tatggtggca aggtgagacc
     1501 acagggagaa gtagctcttc agggtaacac aggacaagct gtcctgcctt gcgtttcctg
     1561 cattggcctc cttcgttcca tctgtcacat gacaaaacag aacaagctgc tcaggttcca
     1621 gcccattgta ccaatgacta tacaatgtca gagcatggga tcgagtcagt tgaataaata
     1681 agaccaggct cttcccagtc ttccttgtta a
//
LOCUS       NM_001437969            4829 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus metadherin (Mtdh), transcript variant 3, mRNA.
ACCESSION   NM_001437969 XM_006241524
VERSION     NM_001437969.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Xiang,Y., Duan,Y., Peng,Z., Huang,H., Ding,W., Chen,E., Liu,Z.,
            Dou,C., Li,J., Ou,J., Wan,Q., Yang,B. and He,Z.
  TITLE     Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells
            Promote Vascular Calcification Through Astrocyte-Elevated Gene-1
  JOURNAL   Calcif Tissue Int 111 (1), 73-86 (2022)
   PUBMED   35195734
  REMARK    GeneRIF: Microparticles from Hyperphosphatemia-Stimulated
            Endothelial Cells Promote Vascular Calcification Through
            Astrocyte-Elevated Gene-1.
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Wang,Y., Zhang,W., Zhu,X., Wang,Y., Mao,X., Xu,X. and Wang,Y.
  TITLE     Upregulation of AEG-1 Involves in Schwann Cell Proliferation and
            Migration After Sciatic Nerve Crush
  JOURNAL   J Mol Neurosci 60 (2), 248-257 (2016)
   PUBMED   27351433
  REMARK    GeneRIF: AEG-1 was expressed mainly in Schwann cells of the distal
            sciatic nerve segment from injury.  Interference of AEG-1 inhibited
            both proliferation and migration of Schwann cells.
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Emdad,L., Sarkar,D., Su,Z.Z., Randolph,A., Boukerche,H., Valerie,K.
            and Fisher,P.B.
  TITLE     Activation of the nuclear factor kappaB pathway by astrocyte
            elevated gene-1: implications for tumor progression and metastasis
  JOURNAL   Cancer Res 66 (3), 1509-1516 (2006)
   PUBMED   16452207
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 4829)
  AUTHORS   Kang,D.C., Su,Z.Z., Sarkar,D., Emdad,L., Volsky,D.J. and
            Fisher,P.B.
  TITLE     Cloning and characterization of HIV-1-inducible astrocyte elevated
            gene-1, AEG-1
  JOURNAL   Gene 353 (1), 8-15 (2005)
   PUBMED   15927426
REFERENCE   9  (bases 1 to 4829)
  AUTHORS   Britt,D.E., Yang,D.F., Yang,D.Q., Flanagan,D., Callanan,H.,
            Lim,Y.P., Lin,S.H. and Hixson,D.C.
  TITLE     Identification of a novel protein, LYRIC, localized to tight
            junctions of polarized epithelial cells
  JOURNAL   Exp Cell Res 300 (1), 134-148 (2004)
   PUBMED   15383321
REFERENCE   10 (bases 1 to 4829)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006241524.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.725942.1,
                                           SRR26360186.2502169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               JAXUCZ010000007.1  67192654-67193350
            698-799             JAXUCZ010000007.1  67208780-67208881
            800-884             JAXUCZ010000007.1  67220475-67220559
            885-1061            JAXUCZ010000007.1  67221235-67221411
            1062-1127           JAXUCZ010000007.1  67222718-67222783
            1128-1364           JAXUCZ010000007.1  67224204-67224440
            1365-1489           JAXUCZ010000007.1  67237466-67237590
            1490-1597           JAXUCZ010000007.1  67240852-67240959
            1598-1738           JAXUCZ010000007.1  67243630-67243770
            1739-1895           JAXUCZ010000007.1  67247056-67247212
            1896-4829           JAXUCZ010000007.1  67247886-67250819
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4829
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
     exon            1..697
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1966
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein LYRIC; lysine-rich CEACAM1 co-isolated protein;
                     metastasis adhesion protein"
                     /codon_start=1
                     /product="protein LYRIC isoform 3"
                     /protein_id="NP_001424898.1"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDP
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE
                     NITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKD
                     WGRNWSDRSIFSGIDGLSSADPSSDWNAPAEEWGNWVDEDRASLLKSQEPISNDQKDS
                     DDDKEKGEGALPTGKSKKKKKKKKKQGEDNSITQDTEDLEKDTREELPVNTSKARPKQ
                     EKACSLKTMSTSDPVEVLIKNSQPIKTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQD
                     TDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET"
     misc_feature    335..1486
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     misc_feature    335..1486
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     exon            698..799
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            800..884
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1127
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1364
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1489
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1597
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1738
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1895
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..4829
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgcca ttgttccgcc gggggaggac agcgaggcct ggcgctggcg ccccgacgcc
       61 acttagcggc cgcctctgga gacactctgt ccccgccgcc ccgtgtcctc ctggcggcgg
      121 cggcgtgagg ccgactggag ggagtgggaa ccctcggccc tccccgtggc ggcggcggcc
      181 acctattccc cactctggag tgaggggcgg ccgcgatgcg cttggcctga ggtgtcgcgg
      241 ccctcgtcgc ttcccacgac tgttccagcg gcgtctgtgc tccccggcgt catcccgaga
      301 gtctctgacg ggagggaaga tggctgcacg aagctggcag gacgaactgg ctcagcaggc
      361 cgaggagggc tctgcccggc tgcgggagtt gctctctgtc ggcctaggtt ttctgcgcac
      421 ggagttgggc ctcgacctgg ggttggagcc gaagcggtac ccgagctggg tgatcctggt
      481 gggcaccggc gctctcgggt tgctgcttct cttcctccta ggttacggct gggccgctgc
      541 ttgcgccggc gcccgcaaaa agcgaaggag cccgccccgc aagcgggagg aggtgacccc
      601 gccgactccg gcccccgagg acccagccca actgaagaat ctcagaagcg aggagcaaaa
      661 gaaaaagaac cggaagaagc tgcctgaaaa gcccaaacca aatggacgga ctgttgaaat
      721 acctgaagat gaagttgtta gaactccccg aagtataact gccaagcagc caccagagac
      781 agacaagaaa aatgaaaagt caaagaaaaa taagaagaag tcaaagtcag atgctaaagc
      841 agtgcaaaac agttcacgcc atgatggaaa ggaagttgat gaaggagcct gggaaactaa
      901 aattagtcac agagagaaac gacaacagcg taaacgtgat aaagtgctga ctgattctgg
      961 ttcattggat tcaactatcc ctgggataga aaataccatc acagttacca ccgagcaact
     1021 tacaactgca tcatttcctg ttggttccaa gaagaataaa ggtgattctc atctaaatgt
     1081 tcaagttagc aactttaagt ctggaaaagg agattctaca cttcaggttt cttcagggtt
     1141 gaatgaaaat attactgtca atggaggagg ctggagtgaa aagtctgtaa aactctcctc
     1201 acaattgagt gcaggtgagg agaagtggaa ctctgtccca cctgcttctg caggcaagag
     1261 aaaaacagag cagtctgctt ggactcaaga ccctggtgat actaatgcaa atgggaaaga
     1321 ctggggaagg aattggagtg atcgctcaat attttctggc attgatggtt tgtcttctgc
     1381 tgatcctagc tcagactgga atgcaccagc agaagagtgg gggaactggg tagatgaaga
     1441 tagagcttca cttctgaagt cccaggagcc gatttctaat gatcaaaagg attcagatga
     1501 tgataaggaa aaaggagaag gagctcttcc aactggaaaa tctaaaaaga aaaaaaagaa
     1561 aaagaagaag caaggtgaag ataactctat cacccaggac acagaagacc tagaaaagga
     1621 cactagagaa gagcttccag tgaatacctc gaaagcccgt ccaaaacagg agaaagcttg
     1681 ttccctgaag accatgagca ctagtgatcc agttgaagta ctcatcaaaa atagccagcc
     1741 tatcaagact cttccacctg ctatctctgc cgagccatct gttactttat caaagggtga
     1801 ctctgacaag agctcttccc aagtgccacc gatgttacaa gacacagaca aacccaagtc
     1861 aaatgctaag caaaacagtg tgcctccctc acagaccaag tctgaaacta attgggaatc
     1921 tccaaaacaa ataaaaaaga agaaaaaggc cagacgggaa acgtgaattt ttttcctaaa
     1981 ttggacatgt gtttacaaac actgtcttga agattatgct gtttatgcaa taatttgtga
     2041 acatgtacag agttttatat aaatttaaac caatttttaa aacaaaactg aacacaacca
     2101 ccataaaatg gaatcaaagg aaagttaatt tatgaaatta agaggtcaac aatacatact
     2161 acagtgctgg aagacactcg ggagagactt tgcaattgaa cgagaatgat cataatttaa
     2221 gaatattatc ctggttttac aacagttccc tgtttacaac agattgtgcc ctgtttcatc
     2281 tgcagctgag gaataatgga ttctgattag agagaaggct gcctagaagc cagtaggcaa
     2341 gtccttggat cttatgcacg accttagacc atttgaatct gttttatgct taaatcaaag
     2401 tgctttgatt aaatgcatac ctgccatatc tttacctatt tgttgtagca atttgtatta
     2461 aaagaatcac aagtgcaaat aaaaggtcat ttatcattta tttaactaaa ctgtcttggt
     2521 ttagtttaca gttctttaaa agttctaaat taaaacattg aaaaatgcaa ttgacagaca
     2581 cctgtatggc ttacaaagtt atttttgata gtcttgcatt acttgaatta ttcaaagtaa
     2641 cagtatattt taaattaaga aaggtaaata tattatttgt ttgatacatt aagactgaga
     2701 ctaacagtgc tcttgtttat gatttgaaaa cttttcaggc aaaatccaac ttaatatttt
     2761 tcctttccct agcaattttc cagtgtcaac tcttagttgc tagtaatttt ttaccttaaa
     2821 aataaagtaa ttcgcaactt ttgagcatac gacggagaat ggaaaagtag tcagacagct
     2881 ttaattgaca ttgtggagac ctccggttat caggaataca tttttttact gccttaacct
     2941 cctgtagtgc gtagaatatg catcaatttc ttgaagggga ttcatgtttt tataagaatt
     3001 ttcatgtaac tattgcaatt gtggtcaaaa aaaggaacat tttctgcttg aaactgtgtt
     3061 gatttaaatg acgtatgatc tgtcaccatt ttcaggcact gtgtgattcc taggaaagtg
     3121 gcaggcctct ctgtaactgt taatagtgca tgctcggcca tgtacactgt aaatagcctt
     3181 taccaaacgt gtttgacaag gaccataatt aacatcactt tagtgaattg taattttaaa
     3241 aaagccatga tttattgatg tgagcggctt gttttcgtgt ggcgccagga atgaacctgt
     3301 ttaaaagcta taaccaatgg tactgatcta tccattaaat actgtcctta tatttgactg
     3361 tagtttaata gtattgtcaa ctaggaaagc tacaagatgt aaaatggttt tcgttctgtt
     3421 gaagactggc cttattaatg gacagctttc ctcagaagtg attaacaact ttttttattg
     3481 ggtgttaaca tctgtttcag gaacatggca gtatgtttac atgttgtcag aagttttgtt
     3541 tgattgaatg ggatttctaa attaacttac ttgtttaaat aaattcagaa atggatagca
     3601 ttgtttttat ttgcttcact attggggtaa ataatagctg atgtgccagg aatggagcct
     3661 tcagatggct gctgtgagct tcatgttccc tcaggggatg ccacgctatg tctcaaggag
     3721 aagttgatag ggagtctgta attacagagt gtgccaaaag gtcagtgctc acaagtttaa
     3781 ttgaactctc tcaactctac ctcactgttc cttttcctta taattctctg ggctagaaca
     3841 aataagaaac tttatttttc acttcaatgt ctccggatgc aatcacttat aggaggtggc
     3901 acctacacca ggtagcaaga ataccgtctt tttgcagagg aatatataat ggggggaagc
     3961 agagtgacac tgggtgggtc agtgtggagg tggcctctat gcctgccttc tctctggctt
     4021 gcgagccagg cagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4081 gtgtgtgtgt gaaggaggca ggtatatgag tgaaaattaa tcattcactg ctctttgcct
     4141 ctgtatagat ctttgtgtgg cagggcaggg atttcttgtc actgatcaga ggaactggtt
     4201 tctgccatca actcagaaaa ctctgagatt taggtaatgg tgattagaga gtggcaacag
     4261 aagactgggt attctctgct ggccggaatg agggcccctg atgccacctg tttccccaaa
     4321 aggctctctg aaaagccttt ctgttgtggg gcggggcatg ggcatgtcag agttctccaa
     4381 ctgcattgtc cctatcttat accctaaatt gagaaacagt tgagagagtc caaaaagaaa
     4441 gttgaaataa aatatcatta atgtaattta ccttgtttaa tttgtgcatg cattttattg
     4501 gggaggggag gttggaataa tttatctaaa actaatggta ttatttcata ggctaatcca
     4561 gtttgtattt gagttaaaga tcccagaggg tagtaattaa ttacagagtt tagtttttct
     4621 taattaaaag cagtcctcta ttaatatagt atgaaatgtc aaaatttagg atttaagttt
     4681 aaggtctaat ggctatttta aagtttttct gtaaactcat tgcacaaact ggaattggaa
     4741 ttgctttcaa aagacttggg aaatgaaaat gtgtcatgta agatgcactg agtgttgtaa
     4801 ataaaatact gtttttgttt tgtttaaaa
//
LOCUS       NM_001437945            7576 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 3, mRNA.
ACCESSION   NM_001437945 XM_063274025
VERSION     NM_001437945.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7576)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7576)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7576)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7576)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7576)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063274025.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.37511.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000015.1  105199266-105199522 c
            258-374             JAXUCZ010000015.1  105182942-105183058 c
            375-464             JAXUCZ010000015.1  105168842-105168931 c
            465-547             JAXUCZ010000015.1  105162379-105162461 c
            548-617             JAXUCZ010000015.1  105160417-105160486 c
            618-713             JAXUCZ010000015.1  105158803-105158898 c
            714-848             JAXUCZ010000015.1  105157736-105157870 c
            849-1023            JAXUCZ010000015.1  105151440-105151614 c
            1024-1091           JAXUCZ010000015.1  105149491-105149558 c
            1092-1166           JAXUCZ010000015.1  105137132-105137206 c
            1167-1307           JAXUCZ010000015.1  105135597-105135737 c
            1308-1505           JAXUCZ010000015.1  105134347-105134544 c
            1506-1628           JAXUCZ010000015.1  105133869-105133991 c
            1629-1711           JAXUCZ010000015.1  105129765-105129847 c
            1712-1834           JAXUCZ010000015.1  105129126-105129248 c
            1835-1914           JAXUCZ010000015.1  105124162-105124241 c
            1915-2102           JAXUCZ010000015.1  105123885-105124072 c
            2103-2168           JAXUCZ010000015.1  105123662-105123727 c
            2169-2261           JAXUCZ010000015.1  105122343-105122435 c
            2262-2385           JAXUCZ010000015.1  105120141-105120264 c
            2386-2507           JAXUCZ010000015.1  105119666-105119787 c
            2508-2594           JAXUCZ010000015.1  105118736-105118822 c
            2595-2684           JAXUCZ010000015.1  105117931-105118020 c
            2685-2800           JAXUCZ010000015.1  105115724-105115839 c
            2801-2870           JAXUCZ010000015.1  105113993-105114062 c
            2871-2996           JAXUCZ010000015.1  105113031-105113156 c
            2997-3068           JAXUCZ010000015.1  105111200-105111271 c
            3069-3215           JAXUCZ010000015.1  105101578-105101724 c
            3216-3299           JAXUCZ010000015.1  105101310-105101393 c
            3300-3411           JAXUCZ010000015.1  105100567-105100678 c
            3412-3590           JAXUCZ010000015.1  105098660-105098838 c
            3591-3704           JAXUCZ010000015.1  105098365-105098478 c
            3705-3822           JAXUCZ010000015.1  105096851-105096968 c
            3823-3956           JAXUCZ010000015.1  105091621-105091754 c
            3957-4068           JAXUCZ010000015.1  105089536-105089647 c
            4069-4135           JAXUCZ010000015.1  105087183-105087249 c
            4136-4183           JAXUCZ010000015.1  105085955-105086002 c
            4184-4227           JAXUCZ010000015.1  105082924-105082967 c
            4228-4343           JAXUCZ010000015.1  105076918-105077033 c
            4344-4481           JAXUCZ010000015.1  105074536-105074673 c
            4482-4664           JAXUCZ010000015.1  105074236-105074418 c
            4665-4778           JAXUCZ010000015.1  105072671-105072784 c
            4779-4994           JAXUCZ010000015.1  105072316-105072531 c
            4995-5052           JAXUCZ010000015.1  105069893-105069950 c
            5053-5130           JAXUCZ010000015.1  105069119-105069196 c
            5131-5237           JAXUCZ010000015.1  105067917-105068023 c
            5238-5360           JAXUCZ010000015.1  105053003-105053125 c
            5361-5474           JAXUCZ010000015.1  105051698-105051811 c
            5475-5621           JAXUCZ010000015.1  105050156-105050302 c
            5622-5832           JAXUCZ010000015.1  105046980-105047190 c
            5833-6023           JAXUCZ010000015.1  105035414-105035604 c
            6024-6124           JAXUCZ010000015.1  105031777-105031877 c
            6125-6263           JAXUCZ010000015.1  105031234-105031372 c
            6264-7576           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7576
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..257
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="upstream in-frame stop codon"
     CDS             138..6386
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 3 is encoded by transcript variant 3;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 3"
                     /protein_id="NP_001424874.1"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MQADKYRTSGRNDKKELVIESPLQYKDAAQADSEAENSALAKPK
                     LIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEEEA
                     QSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADKDE
                     DAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEK
                     ISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKI
                     LQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVK
                     LFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVE
                     PFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQAA
                     MQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQ
                     ACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADFRK
                     PEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCI
                     PKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGR
                     PGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGST
                     KKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEVKW
                     VEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEG
                     HVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAY
                     KAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE
                     NNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFT
                     FMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQ
                     RYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDD
                     RYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGNPL
                     MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPD
                     RNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKA
                     STAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVAHQSLL
                     EANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALK
                     NVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNN
                     FDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFS
                     SDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARI
                     HVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPPVFPYSHTSCQRKSRGGMFR
                     QGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADI
                     YKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFED
                     EDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQ
                     VTHVTPFFDEKELQERKTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAI
                     HCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGS
                     VSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKED
                     QLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQG
                     LTSSSSVV"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    4929..6251
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    4929..6251
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5319..5321,5349..5351,5355..5360,5364..5369,
                     5376..5381,5385..5390,5397..5402)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5319..5321,5349..5351,5355..5360,5364..5369,
                     5376..5381,5385..5390,5397..5402)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5421..5432,5436..5438,5523..5528,5532..5543,
                     5547..5552,5607..5615,5664..5666,5670..5672,5757..5759,
                     5763..5765,5784..5789,5805..5807,5922..5927,5934..5936,
                     5976..5978,5982..5984,5994..5996,6003..6011,6018..6029,
                     6033..6038,6045..6047,6129..6131,6183..6188,6192..6197,
                     6204..6206)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5421..5432,5436..5438,5523..5528,5532..5543,
                     5547..5552,5607..5615,5664..5666,5670..5672,5757..5759,
                     5763..5765,5784..5789,5805..5807,5922..5927,5934..5936,
                     5976..5978,5982..5984,5994..5996,6003..6011,6018..6029,
                     6033..6038,6045..6047,6129..6131,6183..6188,6192..6197,
                     6204..6206)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    6018..6035
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    6018..6035
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            258..374
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            375..464
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..547
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            618..713
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1091
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1505
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1628
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1834
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1914
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2102
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2385
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2507
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2800
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2870
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3215
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3299
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3411
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3590
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3704
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3822
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3956
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4135
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4183
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4227
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4343
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4481
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4664
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4778
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4779..4994
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5052
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5130
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5131..5237
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5238..5360
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5361..5474
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5475..5621
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5622..5832
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5833..6023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6024..6124
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6125..6263
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6264..7576
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccaccc ctgaggctcc gcacttccag ccttgtgcct gggaaacagg cttccttgcc
       61 tttctctggc cagtggtgca gcaggggact ctcagctgtc cctgctgcag gctttctgac
      121 agtggtctgg gtggagaatg caggctgata agtacaggac tagcggtaga aatgacaaga
      181 aggagctggt catcgagtct cccctgcagt acaaggatgc agctcaggca gactcggagg
      241 cagagaactc ggcattggca aagccaaagc tgattgagcc acttgactac gaaaatgtca
      301 tcgtgcagaa gaagacccag atcctgaatg actgtctgcg ggagatgctc ctcttccctt
      361 acgatgactt ccagacggcc atcctgaggc ggcaggggcg ctacgtacgt tccacggtcc
      421 ctgcaaatgc agaggaggaa gcacagagcc tgtttgtcac cgagtgcatc aaaacctaca
      481 actctgactg gcaccttgtg acctatcact atgaagatta ctcaggagag ttccgacagc
      541 ttccaaacaa agtggccaag ttggataaac ttccagttca cgtctatgaa gtcgatgagg
      601 aggctgacaa agatgaggac gctgcttccc ttgggtctca gaagggtgga atcacaaagc
      661 acggctggct gtacaaaggc aacatgaaca gtgccatcag cgtgaccatg aggtcattca
      721 agaggcggtt tttccacctg attcagcttg gcgatggatc ctataatcta aacttttata
      781 aagatgagaa gatctccaag gagccgaaag ggtccatatt cctggattcc tgcatgggcg
      841 tgatccagaa caacagagtc aggcgcttcg cctttgagct caagatgcag gacaaaagca
      901 gttaccttct ggctgcggac agtgaggcag agatggagga gtgggtcaca gtcctcaaca
      961 agatcctcca gctcaacttt gaggctgcaa tgcaagagaa gcgaaatggg gaccctcatg
     1021 aagatgatga acaaagcaaa ctggaaggtt ccggttccgg tttggacagc tacctgcctg
     1081 aacttgccaa gagcaccaga gaagcagaaa tcaaactgaa aagcgagagc agagtgaagc
     1141 tcttttactt ggacccagat acccagaaac tcgacttctc atctgctgaa ccagaagtga
     1201 agccatttga agaaaagttt gggaagagga ttctcgtcaa gtgcaatgat ttgtccttca
     1261 acctgcagtg ctgtgtcgca gagaacgagg aaggacccac gacaaatgtg gagcctttct
     1321 ttgtcaccct gtccctgttc gacataaaat acaaccggaa gatttctgct gacttccacg
     1381 tggacctgaa ccacttctca gtgcggcaga tgctggcccc tgcatcccca gtgctgatga
     1441 acggtggtca gagtccacct gccttccagg atgcccttca ggcggccatg cagtatccga
     1501 agcagggaat attttcagtc acgtgtcctc acccagacat atttcttgtg gccagaattg
     1561 aaaaggtcct ccaaggaagc atcacgcact gtgctgagcc ttacatgaaa agctcagact
     1621 cttctaaggt cgctcagaag gtgctgaaga atgccaagca ggcatgtcaa agactaggac
     1681 agtaccgaat gccgtttgct tgggcagcaa ggacgttgtt taaagacaca tctggaaacc
     1741 tggataaaaa tgccaggttt tctgccatct accggcaaga cagcaataag ctctcaaatg
     1801 aggacatgct caagctgctc gcagacttcc ggaaacctga gaagatggcc aaactcccag
     1861 tgattttagg caatctagac attacaatcg acaacgtttc ctgcgacttc cctaattacc
     1921 tgaattcatc atacattccc atgaggcagt ttgaaacctg cagtaagtct ccgatcacct
     1981 tcgaagtaga ggagtttgtg ccctgcatac ccaagcacac ccagccttat acagtctaca
     2041 gcaatcacct ttatgtttac cccaagtact tgagatacga cagccagaag tcttttgcca
     2101 aggccagaaa cattgcaatc tgcattgagt tcaaggattc cgatgaagaa gactcgcaac
     2161 ccttgaagtg catttacggc agacctggtg gcccagtgtt cacaaggagt gccctcgctg
     2221 cagtcctaca ccatcaacaa agcccagaat tctacgatga gatcaagata gagctgcccg
     2281 cccagctgca cgagaagcac catttactgt tcaccttctt ccacgtcagc tgcgacaact
     2341 cgaccaaagg gagcacgaag aagaaggacg ctgtggagac acaggttggc ttctcctggc
     2401 ttcctctcct gaaagacggc agagtgttga cgaatgaaca gcatatccct gtctccgcca
     2461 acctgccgtc tggctacctt ggctaccagg agctcagcat gggcaggcat tatggtccag
     2521 aagttaagtg ggtggaagga ggcaagccat tgttgaaaat ctccactcat ctggtttcca
     2581 ccgtgtacac tcaggatcag cacttacaca attttttcca atactgtcag aaaacggaat
     2641 ctggagccca agcctcaggg agtgaactag tgaaatacct taagagtctg catgcaatgg
     2701 aaggtcacgt gatgatcgcc ttcctgccga ccattttaaa ccagctattc cgagtcctca
     2761 ccagagccac ccaggaggag gttgcagtta atgtgactcg ggtcattatt catgtggttg
     2821 cccagtgcca tgaggaagga ttggagagcc acttgaggtc atatgttaag tttgcctaca
     2881 aggctgagcc gtatatagca tccgagtata agacagtgca cgaggaactg acgaaatcca
     2941 tgaccaccat tctcaagcct tctgctgatt tccttaccag caacaaactt ctgaagtact
     3001 cttggttttt ctttgatgtg ctgataaagt ccatggctca gcatttgatt gaaaataaca
     3061 aagtgaagtt acttcgaaac cagagatttc cggcctccta ccatcacgcc gtggaaaccg
     3121 tggtgaacat gctgatgccg cacatcacac agaagtttcg agataaccca gaagcatcta
     3181 agaatgccaa tcacagcctg gccgtgttca tcaagagatg cttcaccttc atggacagag
     3241 gcttcgtctt caaacagatc aacaactaca tcagttgctt tgctcctgga gaccccaaga
     3301 ctctctttga gtacaagttt gagtttctcc gtgtggtgtg caaccatgaa cactatattc
     3361 ctttgaactt gccgatgcca tttgggaaag gaagaattca gagataccaa gatctccagc
     3421 ttgactactc tttaacggac gaattctgca gaaaccactt cttggtggga ctgttactaa
     3481 gggaggtggg tactgcactc caggagttcc gggaggtccg tgtcatcgct gtcagtgtgc
     3541 tcaagaacct tctgatcaag cattcttttg atgacagata cacttcaagg agtcaccagg
     3601 caaggatagc caccctctac ctgcctctgt ttggtctgct tattgaaaac gtccagcgga
     3661 tcaacgtgag ggatgtgtcg cccttccctg tgaacccggg cagtatctcg aaggacgaag
     3721 ccctggccgt gcctaccggg aatccactca tgactccgca gaagggaaac acacttgacc
     3781 acagcctgca caaagacctc ttgggtgcca tctccggcat tgcttctccg tatacagctt
     3841 caacccccaa catcaacagt gtgagaaatg ccgactcaag gggctctctc atcagcacgg
     3901 actcggggaa cagccttcca gacaggaacc ccgagaagag caactccctg gacaagcagc
     3961 agagcggcat gctgggaaat tctgtggtcc gctgtgacaa actggaccag tctgagatca
     4021 agagcctgct gatgtgcttc ctctacgtgt tgaagagcat gtctgacgat gccctgttta
     4081 cgtactggaa caaggcttcc actgctgaac tgatggattt ctttaccata tctgaagtgt
     4141 gcctgcacca gttccagtac atggggaagc gctacatagc cagtgtgaga aagatatcaa
     4201 gtgtgcttgg gatttctgta gacaatggct acggccactc ggaggcagat gtcgctcacc
     4261 agtcgcttct cgaagcaaac atcgccactg aggtctgcct cacagctctg gacaccctct
     4321 cgctgttcac actggctttt aagaaccagc tcctagctga ccatggacat aatccactca
     4381 tgaagaaagt ttttgatgtc tacctgtgtt tcctccaaaa gcatcagtca gaaatggctt
     4441 taaaaaatgt cttcactgcc ttaaggtcat taatttataa gttcccctca acgttctacg
     4501 aggggcgggc agacatgtgc gcatctctgt gctatgaggt tctcaagtgc tgtaactcca
     4561 agctcagctc catccgcacc gaggcctccc agctgctcta cttcctgatg aggaacaact
     4621 tcgactacac agggaagaag tcttttgtcc ggacacactt acaggtcatc atctctgtca
     4681 gccagctgat cgcagacgtg gttggcattg gaggaaccag attccagcag tccttgtcta
     4741 tcatcaacaa ctgtgccaat agcgaccggc tcattaagca caccagcttc tcctctgatg
     4801 tgaaggattt gaccaagagg atccgcacag tcctgatggc cacagcccag atgaaggaac
     4861 atgagaacga cccagagatg ctggtggacc tgcagtacag cctggccaag tcctacgcca
     4921 gcacccctga gctcaggaag acatggctgg acagcatggc aaggatccat gttaaaaatg
     4981 gggatctctc agaggcagca atgtgctatg tccacgtgac agctttggta gcggaatatc
     5041 tcacacggaa agaagctgac ctagcactcc agcgggaacc acctgtcttc ccctacagcc
     5101 atacctcctg ccagaggaag agccggggag gcatgttcag acaggggtgc acagccttca
     5161 gggtcatcac accaaacatt gatgaagagg cttccatgat ggaagatgtc ggcatgcagg
     5221 atgtccattt caatgaggat gtgctgatgg agctgctgga gcagtgcgca gatggacttt
     5281 ggaaggcaga gcgctacgag ctgattgctg acatctataa actcatcatc cccatctatg
     5341 aaaagcggag ggactttgag agactagccc acctgtatga cacgctgcac cgcgcataca
     5401 gcaaagtgac agaggtcatg cactcgggcc gcaggctcct ggggacctac ttccgggtgg
     5461 ccttcttcgg acagggattc ttcgaagatg aagacgggaa ggaatacatc tacaaagagc
     5521 ccaaactcac gcctctgtca gagatttctc agagactcct taaactttac tcggataaat
     5581 tcggttctga aaatgtcaaa atgatacagg attctggcaa ggtcaacccg aaggatctgg
     5641 attccaagtt tgcttacatc caggtgaccc atgtgacccc gttctttgat gaaaaggagt
     5701 tacaggagag gaaaacagag tttgaacgat gtcacaacat ccggcgcttc atgttcgaga
     5761 tgcccttcac ccagactggg aagaggcagg gtggcgtgga ggagcagtgt aagcgacgga
     5821 ccatcctgac agcaatacac tgcttcccct atgtaaagaa gcggatccct gtcatgtacc
     5881 agcaccacac tgacctgaac cccattgagg tggccatcga tgaaatgagc aagaaagtgg
     5941 ccgagctccg ccagctgtgt tcctcagctg aagtggacat gatcaaactg cagctcaaac
     6001 tgcagggcag tgtgagcgtc caggtcaatg ctggcccgct agcatacgcc cgagccttcc
     6061 tcgatgacac caacacaaag agataccctg acaataaggt gaagctgctg aaggaagttt
     6121 tcaggcaatt cgtggaagct tgtggccaag ccttggcagt gaacgaacgt ctgattaaag
     6181 aggaccagct ggagtaccag gaagagatga aagccaacta cagggagatg gccaaggagc
     6241 tctccgacat catgcgtgag caaatttgcc ccctggagga gaagacaagc gtgctaccaa
     6301 attccctgca catcttcaac gccatcagtg ggacaccaac aagcacagtg gttcaagggt
     6361 tgaccagttc atcctcagtt gtgtgacttt acctcatgaa ccacacgtgg ggacatgctt
     6421 tgtcatgtgc aaactcagga cgactttcag agctaatcac tggttttgcc aagcacagga
     6481 agaagccatg gggaatggga gagagaaaga gcctggactg tgatatttaa tagcagattt
     6541 tataggagtt gggggaaggt gcacatattt ttttaaatat cactggcaat gtttagtttt
     6601 cctcatgtct taacaggtgt atgtggatac tcttgggctg cagttcaatt ttattcttct
     6661 tacagtatag tattaaaata aatggtctaa aggaaaagag ggaaagtatg ctgggacacc
     6721 tgtagcaggt gtgctgggac acctgtacca gctgtgctgg gacacctgta ccagctgtgc
     6781 tgggacacct gtagcagatg cagcagcact gaacctggga atggggacta agctggaaaa
     6841 atcttgaaaa tatttttctc cctgtggcac attcaggttg agtacaagaa ctatttttgt
     6901 gtctagtttt gaagactgaa gggaattgac tattgagatt ttttactagt gaatgcggag
     6961 acttagagcc tttatatcca tgccttgtgt tgacaacatg agcacttccg aagctgagtg
     7021 tgatgtgagc ctaagcctag tcagcagcat agaaccaaag gcctgcacta gcgaacacac
     7081 ctatgctaaa acctaaaacc ccatgtacat atgttctgtt aatacggcct cctcgctgag
     7141 tccacgtact tactacattt ctacactttt aatacatcag tgtccgtgtt aagtttatta
     7201 ttcgtgaccc atttgtgctg ttctcggtat atgcaaatac attggacttc actgtttatt
     7261 cttgtacata agaagtgcaa tatggagatg tatacagtct ttgctatgtt aggtttataa
     7321 actgttttta aaaagaaatt catccttttg ccaaaatggt ggagtatgtg attggtaaac
     7381 cctaaaccct gtggtgagtg gagggataat ttaaagtttt caccatgtta tattttcttt
     7441 taagacttta atttagtaat tttatatttg ggaaaataaa ggtttttaat ttaactggaa
     7501 tcactgccct gctgtaatta catatcgtgt accccaactg tattaaaaat aacactgctg
     7561 attttctggt aataaa
//
LOCUS       NM_001437908            3904 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 2, mRNA.
ACCESSION   NM_001437908 XM_063282130
VERSION     NM_001437908.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 3904)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 3904)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 3904)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3904)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3904)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 3904)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063282130.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.9802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000002.1  177791620-177791637 c
            19-148              JAXUCZ010000002.1  177786942-177787071 c
            149-226             JAXUCZ010000002.1  177784108-177784185 c
            227-337             JAXUCZ010000002.1  177782701-177782811 c
            338-539             JAXUCZ010000002.1  177779277-177779478 c
            540-635             JAXUCZ010000002.1  177778834-177778929 c
            636-681             JAXUCZ010000002.1  177775282-177775327 c
            682-794             JAXUCZ010000002.1  177774722-177774834 c
            795-869             JAXUCZ010000002.1  177771722-177771796 c
            870-922             JAXUCZ010000002.1  177768704-177768756 c
            923-1008            JAXUCZ010000002.1  177766872-177766957 c
            1009-1180           JAXUCZ010000002.1  177765163-177765334 c
            1181-1379           JAXUCZ010000002.1  177760418-177760616 c
            1380-1657           JAXUCZ010000002.1  177758391-177758668 c
            1658-1830           JAXUCZ010000002.1  177758048-177758220 c
            1831-2020           JAXUCZ010000002.1  177756072-177756261 c
            2021-2075           JAXUCZ010000002.1  177755325-177755379 c
            2076-2250           JAXUCZ010000002.1  177753749-177753923 c
            2251-2323           JAXUCZ010000002.1  177753274-177753346 c
            2324-2519           JAXUCZ010000002.1  177751968-177752163 c
            2520-2608           JAXUCZ010000002.1  177751792-177751880 c
            2609-2662           JAXUCZ010000002.1  177749533-177749586 c
            2663-2744           JAXUCZ010000002.1  177747255-177747336 c
            2745-2962           JAXUCZ010000002.1  177746302-177746519 c
            2963-3068           JAXUCZ010000002.1  177745433-177745538 c
            3069-3136           JAXUCZ010000002.1  177740434-177740501 c
            3137-3334           JAXUCZ010000002.1  177739078-177739275 c
            3335-3904           JAXUCZ010000002.1  177737223-177737792 c
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3904
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..18
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            19..148
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             59..3430
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 2"
                     /protein_id="NP_001424837.1"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGRECMHGALSKPAV
                     VRGQENGLDGTKSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEP
                     ANTDDNYGSSSGNTWNNTGHFEPDDGTRLDFIGVEGSNYPRKFETAPGMIHPGAWRTA
                     TEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMEND
                     SSNLDPSQAPSLAQPLVFSNSKQNAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGS
                     TTGSQFLEQFKTAQALAQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTV
                     HSPFTKRQAFTPSSTMMEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSD
                     NQSSSPQPAQQKLKQQKKKTSLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLS
                     DYESTPTTSASSSQAPSSLYTSTASESSSTVSSNQSQESGYQSGPIQSTTYTSQNNAQ
                     GPLYEQRSTQTRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSE
                     SPSTSSIPSLNETVPAASLLTTASQHSSSLSGLSHSEEIPNTTTTQHSSALSTQQNTL
                     SSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSL
                     GLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGY
                     DDLQMLQTRFPLDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATT
                     LAQPQQNQTQTHHTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPT
                     SSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFE
                     KQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQ
                     QDGQTGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1652..1735
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1652..1735
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            149..226
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..337
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..539
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..635
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..681
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..794
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..869
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..922
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1008
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1180
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1379
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1657
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1830
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2020
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2075
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2250
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2323
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2519
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2608
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2662
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2744
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2962
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3068
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3136
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3334
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3904
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgagta ttcttccttg taaatactgt tatttgtata tactgtaaat
       61 gatgacgtcg gtgggcacta accgagcccg gggaaactgg gaacaacctc aaaaccaaaa
      121 ccagacacag cacaagcagc ggccacaggc cactgcagag caaattcgac ttgcacagat
      181 gatttcggac cataatgatg ctgactttga ggagaaggtg aaacaattga ttgatatcac
      241 aggcaaaaac caggatgaat gtgtgattgc tttgcatgac tgcaatggag atgtcaacag
      301 agccatcaat gttctcctgg aaggaaatcc agacacgcat tcctgggaga tggtcgggaa
      361 gaagaaagga gtctcaggac agaaggatgg tggacaaact gaatctaatg aagaaggaaa
      421 agaaaatcga gaccgggaca gagactatag tcgacgacgt ggtgggccac caagacgggg
      481 gagaggtgcc agccgtggac gagagtgtat gcatggggct ttatcaaaac cagctgtggt
      541 tcggggccag gaaaatggat tggatggcac taagagtggt ggaccttctg gaagaggcac
      601 agacagaggg agaagaggcc gtggccgggg cagaggtagt tctggtagac gaggaggaag
      661 gttttctgct caaggaatgg gaacctttaa ccctgctgat tatgcagagc cagccaacac
      721 tgatgataac tatggcagta gcagtggcaa tacatggaac aacactggcc actttgaacc
      781 agatgatgga acaagacttg atttcattgg ggttgagggg tcaaattatc cccgaaaatt
      841 tgagactgct cctggtatga tacatccagg tgcatggagg actgcaacag aagagtgggg
      901 aactgaagat tggaatgaag atctttctga gaccaagatc tttactgcct ctaatgtgtc
      961 ttcagtgcct ctgcctgcgg agaatgtgac aatcactgct ggtcagagaa ttgatcttgc
     1021 tgttctgttg gggaagacac cgtcttcaat ggagaatgat tcatctaatc tggatccatc
     1081 tcaggctcct tccctggccc agcctctggt attcagtaat tcgaagcaga atgccatatc
     1141 acagcctgct tcagggaata cattttctca tcatagcatg gtgagcatgt tggggaaagg
     1201 atttggtgat gttggggaag ctaaaggtgg cagtacaaca ggctctcagt tcttggagca
     1261 attcaagact gcacaggccc tggctcaact ggcagctcaa cattctcagt ctggaagcac
     1321 caccacctcc tcttgggata tgggctcaac aacacaatca ccatcactgg tgcagtatga
     1381 tttgaagagt gcaaatgatt caacagtgca cagtcctttt acaaagcgcc aggcattcac
     1441 cccatcatca accatgatgg aggtgttcct tcaggagaag ccacctgcag tggctacctc
     1501 gacagctgca cctcctcccc cctcttctcc tctgccaagc aaatccacct cggctccaca
     1561 gatgtctccg gggtcttcgg acaaccaatc ctccagccct cagccggctc aacagaaact
     1621 gaaacagcaa aagaagaaaa cctccttgac gtctaagatt cctgctctgg ctgtggagat
     1681 gcctggctca gcagatatct cagggctaaa tctgcagttt ggggcattgc aatttgggtc
     1741 agagcctgtc ctttctgatt atgagtccac ccccaccacg agcgcctctt caagccaggc
     1801 tcccagtagc ctgtatacca gcacggccag tgagtcttca tctacagttt catctaatca
     1861 gagtcaggag tctggttatc agagtggccc aattcagtcg acaacttata cctcccaaaa
     1921 taatgctcag ggccctctat atgaacagag atccacacag acacggcggt atcccagctc
     1981 catctcttca tcaccccaaa aggacctgac tcaggctaag aatggtttca gctctgtgca
     2041 ggccacgcag ttacagacca cgcaatctgt tgaaggtgct acaggctctg cagtgaaatc
     2101 tgaatcacct tccacttcta gtataccctc tctcaatgaa acagtacctg cagcttcctt
     2161 actgacgaca gccagtcagc attcatcctc cttaagtggc ttgagccata gtgaggagat
     2221 tccaaatacc accaccacac aacatagcag tgcattatct acacagcaga ataccctttc
     2281 ttcatcaaca tcttctgggc gtacttcaac atctactctt ttgcatacaa gtgtggagag
     2341 tgaagcgaat ctgcattctt cctccagcac tttctctacc acgtccagca ctgtctctgc
     2401 acctccccca gtggtcagtg tctcctccag tctgaatagt ggcagtagcc tgggccttag
     2461 cctgggcagc aactctactg tcacagcctc aactcgaagc tcagttgcta caacttcagg
     2521 aaaagctcct cccaaccttc ctcctggagt cccgccattg ttgcctaatc catatattat
     2581 ggctccaggg ctgttacatg cctacccgcc acaagtatat ggttatgatg atttacagat
     2641 gctccagaca agatttccat tggattacta cagtatcccg tttcccacac ccaccactcc
     2701 acttactggg agggatggta gcctggccag caacccttac tctggcgacc tcaccaagtt
     2761 cggccgcggg gatgcctcct ccccagcccc agccacaacc ttggcccaac cccaacagaa
     2821 ccagacgcag actcaccaca ccacgcagca gacattcctg aacccggcgc tgcctcctgg
     2881 ctatagttac accagcctgc catactacac aggggtcccg ggcctcccca gcaccttcca
     2941 gtatgggcct gctgtgttcc ctgtggctcc tacctcttcc aagcagcatg gtgtgaatgt
     3001 cagtgtgaat gcctcggcca cccctttcca acaaccaagt ggatatgggt ctcatggata
     3061 caacactggt gtgtcagtca cctccagtaa cacgggcgtg ccagatatct cgggttctgt
     3121 gtactccaaa acccagcagt cctttgagaa acaaggtttt cattccggta ctcctgctgc
     3181 ctccttcaac ttgccttcag ccctaggaag tggagggccc atcaatccag ccacagctgc
     3241 tgcctaccca cctgccccct ttatgcacat tctgacccca catcagcagc cacactctca
     3301 gatccttcac catcacctgc agcaggatgg ccagacgggc agcgggcaac gtagccagac
     3361 cagctccatc ccgcagaagc cccagaccaa caagtctgcc tacaacagct acagctgggg
     3421 ggccaactga ggccctgacc ctcttctcct gtcccatctt ctgagagggc ttctcagcct
     3481 ggaaactatg gaaacagcat caaagagaga aaagaatgtg gggcgattcc gctgctccac
     3541 acccccagcg gcccatccca cacctcagct tcatgtctgt cccatccctc taccatccta
     3601 ccctgttgta tgtattatag gatttgtatt ttcttccctc ccctcctctt cctcctttct
     3661 ctttgcattc aagattatga aactttgctg tgggccctgc ctttccctca cttcttcctg
     3721 ttcaccctgg tggtgtatgg gtgaggtggg aaggtgaaac ccctccccca ccccaaatat
     3781 atatcagccc aacagcccta agtctcctcc tttattatta ggaaagccaa accacacaca
     3841 cacacacaca cacacacaca cacactaaaa aaaaatggcg tcataaatat gaacagcatt
     3901 gtca
//
LOCUS       NM_175598               3001 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RIC8 guanine nucleotide exchange factor B
            (Ric8b), transcript variant 1, mRNA.
ACCESSION   NM_175598
VERSION     NM_175598.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Lopez-Benito,S., Lillo,C., Hernandez-Hernandez,A., Chao,M.V. and
            Arevalo,J.C.
  TITLE     ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated
            secretion
  JOURNAL   J Cell Sci 129 (9), 1866-1877 (2016)
   PUBMED   26966186
  REMARK    GeneRIF: overexpression of ARMS blocked NGF-mediated secretion,
            without affecting basal secretion, a decrease in ARMS resulted in
            potentiation. Similar effects were observed with synembryn-B, a
            protein that interacts directly with ARMS. Downstream of ARMS and
            synembryn-B are Galphaq and Trio proteins, which modulate the
            activity of Rac1 in response to NGF
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Aguilar,R., Grandy,R., Meza,D., Sepulveda,H., Pihan,P., van
            Wijnen,A.J., Lian,J.B., Stein,G.S., Stein,J.L. and Montecino,M.
  TITLE     A functional N-terminal domain in C/EBPbeta-LAP* is required for
            interacting with SWI/SNF and to repress Ric-8B gene transcription
            in osteoblasts
  JOURNAL   J Cell Physiol 229 (10), 1521-1528 (2014)
   PUBMED   24585571
  REMARK    GeneRIF: Results indicate that a functional N-terminus in
            C/EBPbeta-LAP* is required for interacting with SWI/SNF and for
            Ric-8B gene repression in osteoblasts.
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Chan,P., Gabay,M., Wright,F.A. and Tall,G.G.
  TITLE     Ric-8B is a GTP-dependent G protein alphas guanine nucleotide
            exchange factor
  JOURNAL   J Biol Chem 286 (22), 19932-19942 (2011)
   PUBMED   21467038
  REMARK    GeneRIF: Ric-8BFL-catalyzed nucleotide exchange probably proceeds
            in the forward direction to produce Galpha-GTP in cells.
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Klattenhoff,C., Montecino,M., Soto,X., Guzman,L., Romo,X.,
            Garcia,M.A., Mellstrom,B., Naranjo,J.R., Hinrichs,M.V. and Olate,J.
  TITLE     Human brain synembryn interacts with Gsalpha and Gqalpha and is
            translocated to the plasma membrane in response to isoproterenol
            and carbachol
  JOURNAL   J Cell Physiol 195 (2), 151-157 (2003)
   PUBMED   12652642
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Tall,G.G., Krumins,A.M. and Gilman,A.G.
  TITLE     Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein
            guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 278 (10), 8356-8362 (2003)
   PUBMED   12509430
  REMARK    GeneRIF: two mammalian homologs of the Caenorhabditis elegans
            protein Ric-8 were identified: Ric-8A (Ric-8/synembryn) and Ric-8B
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_175598.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY177755.1, SRR26360172.698421.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000007.1  20729896-20730066   c
            172-219             JAXUCZ010000007.1  20722480-20722527   c
            220-828             JAXUCZ010000007.1  20701536-20702144   c
            829-923             JAXUCZ010000007.1  20691843-20691937   c
            924-1152            JAXUCZ010000007.1  20678508-20678736   c
            1153-1248           JAXUCZ010000007.1  20677768-20677863   c
            1249-1393           JAXUCZ010000007.1  20669149-20669293   c
            1394-1538           JAXUCZ010000007.1  20658000-20658144   c
            1539-3001           JAXUCZ010000007.1  20636337-20637799   c
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..3001
                     /gene="Ric8b"
                     /note="RIC8 guanine nucleotide exchange factor B"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
     exon            1..171
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1650
                     /gene="Ric8b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synembryn-B; resistance to inhibitors of cholinesterase 8
                     homolog B; resistance to inhibitors of cholinesterase 8B;
                     heterotrimeric G protein guanine nucleotide exchange
                     factor-like protein Ric-8B; chaperone Ric-8B"
                     /codon_start=1
                     /product="chaperone Ric-8B isoform 1"
                     /protein_id="NP_783188.1"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
                     /translation="MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESADEDKRK
                     KLCEGIFKVLVKGVPTTCQVPCLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESD
                     DSLEKVSEFPVIVESLKCLCNIVFNSQVAQQLSLELNLAAKLCNLLRKCKDRKFINDI
                     KCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHSGPP
                     LSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEE
                     LHSNAVNLLSNVPVSCLDVLICPLTHEETAQEAATLDELPGDKTAEKDTALKSSAMVY
                     NGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPL
                     RDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAG
                     LLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKPMGLKPDGTITPLEEALSQ
                     YSVIEETSSDTD"
     misc_feature    283..1536
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     misc_feature    283..1536
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     misc_feature    1489..1491
                     /gene="Ric8b"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q80ZG0.1); phosphorylation site"
     misc_feature    1504..1506
                     /gene="Ric8b"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q80ZG0.1); phosphorylation site"
     exon            172..219
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            220..828
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..923
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1152
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1538
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..3001
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggtag cgggggcgcg aggcgtttac ctgggaggca gcggctgggg cgcgcacagc
       61 ggctgcggct cccccgcacc tgcggccatg gatgaagagc gcgccctcta catcgtccgg
      121 gccggcgagg cgggggctat cgagcgggtc ctgagagatt acagcgacaa gcatagggct
      181 actttcaaat ttgaatcagc agatgaagat aaaagaaaga aactctgtga aggcatattt
      241 aaggtcctgg taaagggtgt cccaacaaca tgccaagtgc cctgcctgga agttctccgc
      301 attctctcca gagacaaaaa gattttagct cctgtaacaa ctgaggaaaa tatgcaaata
      361 ctgctgagac tggccaagct ccatgagtcg gacgattctt tggagaaggt gtcagagttc
      421 ccggtcattg tggagtcatt gaaatgtctt tgtaacatcg tgttcaacag tcaggtggca
      481 cagcagctta gcctggaact gaatctcgct gcaaagctct gtaacctcct gaggaagtgc
      541 aaggaccgaa aatttatcaa tgacataaag tgctttgacc tgcgcttgct ctttgtcctg
      601 tcacttttgc acactgacat caggtcacaa ttgcgctatg agctccaggg actgccgctg
      661 ctaacccaga tcttggaaag tgcctttagc atcaagtgga ccgatgagta tgagtcggcc
      721 atagaccata gtggacctcc tctctcacct caggagacag actgtgccat tgaggccctc
      781 aaagctctgt tcaatgtgac ggtagacagt tggaaggtgc ataaagagag cgattctcat
      841 cagttccgtg tcatggccgc tgtccttcgc cactgtttac taattgtagg tccaaccgaa
      901 gacaaaacgg aagagctgca cagtaatgcc gtcaaccttt taagcaatgt tccagtctct
      961 tgtttggatg ttctcatttg tccattaacc catgaagaaa cagcccagga ggcagcaact
     1021 ctagacgaac tgcccggtga taagacagca gagaaagaca cggctttgaa gagcagtgcc
     1081 atggtataca atggcatgaa catggaggcc atccacgttt tactcagttt tatggagaag
     1141 aggattgata agggaagcag ctatagagag ggtctaactc cagttctcag cttattaaca
     1201 gaatgttccc gagcccatcg gaacatccga aaatttctca aagatcaggt gttaccacct
     1261 ttgagggatg tgacaaatcg accagaagtc ggctcaaccg tgagaaataa gctggtgcgc
     1321 ctcatgacac acgttgacct cggagtcaag cagattgctg ctgagttcct cttcgtcctt
     1381 tgcaaagagc gagtggatag tctgctgaag tacactggct atgggaacgc tgcaggactg
     1441 ctggctgcca ggggcctctt ggctggagga agaggagaca attggtactc agaggacgag
     1501 gacacggaca ctgaggaata caaaaacgca aaaccaaaag aggagttgct taaaccaatg
     1561 ggactaaaac ctgacgggac aataacgcct ttggaggaag cgctcagcca gtattctgtc
     1621 atcgaagaga ccagctcgga cacagactga aagcgccgtc acctgctccc tctcaatatg
     1681 gcttttatca gcatcttttc tctgtagctc caggggaatc ttctctagaa cgtttatgcc
     1741 ctcgctttgg ctagaaacac attaactggt ttactcatcg ggaatccagc atatttaaga
     1801 ggtaatcctg tgttttctgc aacattgagg cattcgtaca gagctgcagt caggcagagt
     1861 tgcggggcta gaagcagaag ctgccatccc attgcaccag gacggaggat gggacttcac
     1921 ttggcaaagc agccctggtc aaatctggca gtcctattgc cgggaattcc tagccgaaga
     1981 ttcggccgtg tccttccacc catcgtataa accgcccctc tgagtctctc cagcgaccca
     2041 aggcacagga gagtccgagg agctgctaaa caagggctga ggcaagcaac tccttaggtc
     2101 agcgctgact gaatggaagc caggcagctg ctccgaaagc ctagccccac ccttcatttc
     2161 agttttatac aaatgtggaa acacacacat acacgcacgc atacgcgcgc gcgcgcgcac
     2221 acacacacac acacacacac acacacacac acacacacac acacacacac acacacacac
     2281 acacacacac ggccccagac ttacaaacct attaagctct cacagttggt tacttagcta
     2341 acacttgaga ttacatttct ccctaggagg agttagcagt gatgggttag ttcaggcagc
     2401 tccacgtgcc tatttacccc tcgatcctga acactactag aaccgtaggg ctggaccaca
     2461 cctgtaccgc tgcgtccaca gcgtgcattc tgagatacca ctcagggtgc caagttcaca
     2521 ctcatcctca ggcaacagag aggatggggc tccccgagta gtgggagttc ttttgtggcc
     2581 tgtgctgggg cagggagcca acagcaccca tttgtacata caggtcattc gtgtgtcaca
     2641 tgttctaaac aggggtctct gtgtgtattt gtgtgtgtgt tctacctttc taccatatgt
     2701 gatcagttta atggtaactt tatttattta aaaaaaaaga aacacagata gttactattg
     2761 aactgattaa ggctgtgtat ttgtactcct aggaatggtc atatgaagta gatgtgcaat
     2821 catgtagaca gcaggccaag gtgatcagtg gctaaggttg gaaaggggtt ggtttctctc
     2881 atatatgtat gtatgtgtgt gtagatgcgc atacataggt atatgcacac atagattatg
     2941 tgcttggcca ctgcctttta aaactttaaa ttaaataaaa cgttggggat gattcaattt
     3001 a
//
LOCUS       NM_001437975            2220 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus gasdermin D like 1 (Gsdmdl1), transcript variant
            3, mRNA.
ACCESSION   NM_001437975 XM_039079168
VERSION     NM_001437975.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039079168.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.41290.1,
                                           SRR26360181.1065105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  97509310-97509354
            46-75               JAXUCZ010000007.1  97509567-97509596
            76-220              JAXUCZ010000007.1  97509983-97510127
            221-518             JAXUCZ010000007.1  97510569-97510866
            519-705             JAXUCZ010000007.1  97512128-97512314
            706-880             JAXUCZ010000007.1  97512838-97513012
            881-986             JAXUCZ010000007.1  97515701-97515806
            987-1034            JAXUCZ010000007.1  97516474-97516521
            1035-1210           JAXUCZ010000007.1  97517084-97517259
            1211-1352           JAXUCZ010000007.1  97517640-97517781
            1353-1426           JAXUCZ010000007.1  97518224-97518297
            1427-2220           JAXUCZ010000007.1  97518995-97519788
FEATURES             Location/Qualifiers
     source          1..2220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="gasdermin D like 1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
     exon            1..45
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            46..75
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            76..220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="upstream in-frame stop codon"
     exon            221..518
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1444
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="isoform 3 is encoded by transcript variant 3;
                     gasdermin domain containing protein RGD1359449"
                     /codon_start=1
                     /product="gasdermin D like 1 isoform 3"
                     /protein_id="NP_001424904.1"
                     /db_xref="GeneID:314959"
                     /db_xref="RGD:1359449"
                     /translation="MSSLFLRSTKSLVRELGRKGELVPVDSLNSSQRLRPFCLVRKKH
                     KHSLWPWDTPLIPTDFSLLDVLEPGCPDPEVNHSKPIYSWEKEAEGLTGAVSVSAGLQ
                     SQVTGSGTTTCLSALAVQTLWVSPFTWEMLLEKRKLRSPRPSFLQELQSRKERESLYV
                     VTEAVETLQDTILQSHDQMRGAGQLSLLQLGHVQVQGQSHVDTEKMVSIPQGSVLAYR
                     VLQLVVEEDGWAVLYFPERKLCRNARVAIAFSQESGEESNFYSLRDQADSQLQDLVTL
                     SSERRATLLGALQELLRDQQALQELEDTLEQALDTGLLAQLEGPGGCVLCILQDSTSN
                     LSCSKGRAILYILGALAALSEPQHCLLAQSIERQILSEELELEYSVP"
     misc_feature    308..1012
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    308..1012
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin pore forming domain; Region: Gasdermin;
                     pfam04598"
                     /db_xref="CDD:398339"
     misc_feature    1070..>1438
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     misc_feature    1070..>1438
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /note="Gasdermin PUB domain; Region: Gasdermin_C;
                     pfam17708"
                     /db_xref="CDD:407590"
     exon            519..705
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            706..880
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            881..986
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1034
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1210
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1352
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1426
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..2220
                     /gene="Gsdmdl1"
                     /gene_synonym="RGD1359449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggtagg tcagctgggt ggcacccacc agcagccacc ccgaggtccc aggagggcga
       61 tgcttgagga cccagacagg tgaatcccag agcccacctc agggaggtcc tggcttcaat
      121 gtcaagaaaa ccatgataca acgcaactgg agataagagg aaactggagt ccaccttagg
      181 tccttccgca caggaatttg tacaaccaca gggaaagcaa atcaggccag cttgcagcta
      241 tcacgaaggg atcccatatc cagcccggga tgatattgtc ccttgcctct caaggagcat
      301 gtcatctctg ttcttgagga gcaccaaaag cctggtgaga gagctgggca ggaagggtga
      361 gctggtgccg gtagacagcc tgaacagttc acagcgcctg cgccccttct gcctggtgag
      421 gaagaagcac aagcattccc tctggccttg ggacacaccc ctcatcccca cagacttctc
      481 cctgctggat gtgctggagc ctggctgccc tgacccagag gtgaaccaca gcaagcccat
      541 ctattcctgg gagaaggagg cagagggatt gacaggagct gtgagcgtga gtgctgggct
      601 gcagagccag gtgactggaa gcggcacgac cacctgcctc tctgccttgg cggtgcagac
      661 actctgggtc tccccgttta cctgggagat gcttcttgag aaaaggaaac tgaggtcgcc
      721 taggccctcg ttcctccagg aactacagag ccggaaggag agggagagcc tatatgtggt
      781 gaccgaggct gtggagaccc tgcaagatac catacttcag agccacgacc aaatgcgagg
      841 agccggacag ctgtccctcc tacagctggg ccatgttcag gtccagggac agagccatgt
      901 ggacacagag aagatggtga gcatcccaca gggcagtgtt ctggcctaca gggttctgca
      961 gctagtggtg gaagaagatg gctgggctgt cctttacttc cctgaaagaa agctctgcag
     1021 gaatgccaga gtagctatag ccttcagcca ggaatcagga gaagagtcta acttctacag
     1081 cttgcgggac caagcagata gccagttgca ggacctggtc acattatcct cagagcgacg
     1141 ggccacattg cttggtgccc tccaggagct actacgggat cagcaggcac tccaggagct
     1201 agaggatacg ctggaacagg ctctggacac agggctgctg gcacagctgg agggccctgg
     1261 aggctgtgtc ttatgcatcc tccaagactc tacaagcaac ttgtcatgct cgaaaggcag
     1321 ggctatcctc tatattcttg gagccttagc agcactgagt gaaccccagc attgcctgct
     1381 ggcccagtcc atagagagac aaatcctatc tgaggaactg gagctggagt actctgtgcc
     1441 ctgaagagtg aggatgaggt cctcatccta aacctggtgc agggctgtgg gctagagcta
     1501 gagaagtctg gctgccagct cccctgggac cctacagtgg tacctcagct ttctgcactc
     1561 tatgcatgcc tcacagggct gcagctactg actgacccaa gccctgggct ttctaggaca
     1621 gtgcctgaag aggaaacact tatctgtccc taaggtctca tccaacctga ctcctggcag
     1681 cctgggatgt cactaaccct ctctagtggt cacagctgat gacagggttt caccaggaaa
     1741 ggccccacac tacacttaag actggttcca gacatcggaa acacctattc agaacaagta
     1801 tcctgaatca ggattctgtc tgagcagtgc aggctggctg cagaacagtt tggctgtgta
     1861 tcttaggtag catagtcccc tctgtactca ggtaaaatca gccattgtaa aatgagattt
     1921 gtggtcattc cccaggcaca agaactttgt aaaagtatat gtgacatgct tacaagagtg
     1981 ctgttattgt atggtggcaa ggtgagacca cagggagaag tagctcttca gggtaacaca
     2041 ggacaagctg tcctgccttg cgtttcctgc attggcctcc ttcgttccat ctgtcacatg
     2101 acaaaacaga acaagctgct caggttccag cccattgtac caatgactat acaatgtcag
     2161 agcatgggat cgagtcagtt gaataaataa gaccaggctc ttcccagtct tccttgttaa
//
LOCUS       NM_001191577            3744 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus midnolin (Midn), transcript variant 3, mRNA.
ACCESSION   NM_001191577 XM_002729765 XM_006240911
VERSION     NM_001191577.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3744)
  AUTHORS   Obara,Y. and Ishii,K.
  TITLE     Transcriptome Analysis Reveals That Midnolin Regulates mRNA
            Expression Levels of Multiple Parkinson's Disease Causative Genes
  JOURNAL   Biol Pharm Bull 41 (1), 20-23 (2018)
   PUBMED   29311479
  REMARK    GeneRIF: These findings indicate that MIDN regulates the expression
            of a wide variety of genes, including multiple Parkinson's Disease
            causative genes and is associated with Parkinson's Disease onset.
REFERENCE   2  (bases 1 to 3744)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3744)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   4  (bases 1 to 3744)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_006240911.5, NM_001191577.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.27605.1,
                                           SRR26643290.24867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000007.1  10208716-10208794   c
            80-710              JAXUCZ010000007.1  10206769-10207399   c
            711-798             JAXUCZ010000007.1  10205648-10205735   c
            799-861             JAXUCZ010000007.1  10205404-10205466   c
            862-990             JAXUCZ010000007.1  10203344-10203472   c
            991-1308            JAXUCZ010000007.1  10202930-10203247   c
            1309-1450           JAXUCZ010000007.1  10202592-10202733   c
            1451-1714           JAXUCZ010000007.1  10201724-10201987   c
            1715-3744           JAXUCZ010000007.1  10198761-10200790   c
FEATURES             Location/Qualifiers
     source          1..3744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3744
                     /gene="Midn"
                     /note="midnolin"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
     exon            1..79
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            80..710
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    328..330
                     /gene="Midn"
                     /note="upstream in-frame stop codon"
     CDS             475..1992
                     /gene="Midn"
                     /note="isoform 3 is encoded by transcript variant 3;
                     midbrain nucleolar protein"
                     /codon_start=1
                     /product="midnolin isoform 3"
                     /protein_id="NP_001178506.1"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
                     /translation="MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRY
                     DLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPT
                     VEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKYRLILFKRPWHRQG
                     PQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAA
                     AAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSPVTAGTFQSHAASTTC
                     PEQTDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQD
                     SSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCSPASPAPDLTPKTTSC
                     EKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDAR
                     GPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     misc_feature    937..1002
                     /gene="Midn"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1156..1389
                     /gene="Midn"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1792..1929
                     /gene="Midn"
                     /note="propagated from UniProtKB/Swiss-Prot (D4AE48.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            711..798
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            799..861
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            862..990
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1308
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1450
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1714
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..3744
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccggcac ggccacctct caccacgacc catacgcagg tcgtctggag cagtggtgac
       61 acaggaccta cggcacccga tcttgagagc agcggctgcg gctgttgcta agggaaggga
      121 cgcgcggggt agcacgaccc gagagggatc caggcaccgt gcgaaccagg atagctcgcc
      181 ccgtttctgt tggaccctcc ccgtgccgta ccctggtcgc tgtcaaacgc cctagaaacc
      241 ggatcgcaga ccccaccccg gggcgcaacc caaggatccc acgcgacccc gagcaccatt
      301 cggattcttg attgccggct ctattgctaa cgttgggacc ttccccaagg ggcgcacgca
      361 ctgctcttgt ccctgggcgc ccacggagca gaggaggacc ttgttttggc gggggagtcc
      421 cggcaaggat tggaggcgac ccgcaggccc ccagttatcc tgcgcgcgcc ggggatggag
      481 ccgcagcccg gcggcgcccg gagctgccgg cgcggggccc ccggtggcgc ctgcgagctg
      541 agcacgaccg cggaatcggc cgcacccatg agcctggcga tccacagcac tacggggacc
      601 cgctacgacc tttcggtgcc ccacgacgag accgtggagg ggctgcgcaa aaggctgtcc
      661 caacgcctca aagtacccaa ggaacgcctg gcgctgcttc acaaagacac ccggctcagt
      721 tcggggaagc tgcaggaatt cggcgtgggg gatgggagca agttgacgct cgtgcccacg
      781 gtggaagctg gcctcatgtc ccaggcctcg aggccggagc agtccgttat gcaagccctg
      841 gaaagtttga ctgagaccca gcccccagcg acacccgggc caggccgggc tgccggagga
      901 ggcttccgga aatacagatt gattttattt aagcgtccgt ggcaccgaca gggaccccag
      961 agcccagaga ggggcggcga gaggccccag gtcagtgact ttttgtcagg ccgatcgcct
     1021 ttgaccctgg ccctgcgagt tggggatcac atgatgtttg tacaattgca actggcagcc
     1081 caacacgccc cactccagca ccgccatgtg ctggccgcgg ctgccgcagc tgctgccgct
     1141 gcccggggag attccagcat agctacccca gtatcctcac cttgtcggcc cgtgtccagt
     1201 gccgcccgtg tccccccagt atccagcagc ccttcttcgc ctgtgtcccc ctcacctgtc
     1261 accgctggca ccttccaatc ccatgcagcc tccacgactt gtcctgagca gacggactgt
     1321 tctccacccg ccagcagcaa caccacatcc accccaggca gcagccccac cccccgatcc
     1381 cgcaaacccg gtgcagtcat tgagagcttc gtgaaccacg ctccaggggt cttctcaggg
     1441 accttctctg gcacactgca ccccaactgc caggatagta gtgggcggcc tcggcgtgac
     1501 atcggcacca ttctgcagat actcaatgac ctcctaagtg ccacaaggca ttaccagggc
     1561 atgccggcct cactgaccca gctccgctgc cacgcgcagt gctcacctgc ctcaccagcc
     1621 cctgacctca cccccaaaac tacctcctgt gaaaagctgg caaccccatc actgctccag
     1681 ggccagagcc agatccgaat gtgcaagccc cctggagacc gtctgcgaca gacagagaac
     1741 cgtgccacac gctgcaaagt ggaacgcctc cagctcctgc tgcagcagaa gcgcctgcga
     1801 aggaaggcac ggcgggacgc ccggggtcct taccactgga ccccaagccg caaagctggt
     1861 cgtagtgaca gcagcagcag tgggggtgga ggtagcccca gcgaggccac aggcttgggc
     1921 ctcgacttcg aggactccgt ttggaagcct gaagtcaacc cagacatcca gtccgagttt
     1981 gtggtggctt aaagaatccc cttgggcctg aacatcctct accccataca cggggcagga
     2041 ggacgacaca gactggacgc tgagcggccc agctctgggg gggaggggca ggaggtcacc
     2101 tccattgcca cttaccagcc tttctgattc ttttttagct cctcccctgg ttgtctaccc
     2161 tgcatccctg gtcacgtgcc cacctgtctt tcttccctta ccatggtcag ggcctctgag
     2221 acagggccct tccctcccac cttctccagt tccaaatatg tagcagtctg ttcccagatg
     2281 gcccagacgg aggaagccac ccaccccagc ccttccgctc tgcctagctc tccccacccc
     2341 cttccataac ccaattcagg tttttaaact caatgtagat tctccaagca ctttacagat
     2401 gagggttggg gaccccagga tgagtgcgcc cccctcccct tcccctctgc agacttggcc
     2461 accattccag gccagctggc tcccccaccc ctcccatccc ggaaagctac tagatacact
     2521 cacagaggat acctttgtcc acaatgccca cttaactcac agccttcctc ctgcctcggt
     2581 ctcccaagtg ctacaatgac aggctttgcc actatgcctg gccgcccttg ctcttgccac
     2641 aagctaattc gatggagact gctggagcag gggggctgtt tgttagtcag gtgggggatg
     2701 ctccttttcc tcatgagagg aggctaggcc tcgcaccacc ctccctggac actggcctct
     2761 tggtctcctc cctccacaca cccacttatt tccctaacct tccttcccaa tggggcttga
     2821 gggactattt atagacttca tttttctgac tgagccagta atggtttcta tcctctaggg
     2881 gaaagaaaag aaactggggt agcttgtagg aggaggggcc cagagagaca cccctgtacc
     2941 tcttctctag tcccagcctg cagctgggga tgggaagaga ggtgctgagc tgtgactgca
     3001 ttaaccccac cctggggagg gcgggcgcac tgctgatcca cattggctcc atggatgaga
     3061 gccctcccct cggattgggg cccatacagc aggggtgatc ttgtggggtt tttttcctcc
     3121 acattttgag atttttgtga taaatgggat gtgtgcccac ccctgatgcc tgtccacgtt
     3181 gtctagactc cacctgtcca cggttccttt gatctaggct gtgaacccat ccttgtcttc
     3241 ccccactgtg tgtttaaacc gttaatggtt tgggatgtga acgtgtgttg actagctgta
     3301 aaggtttttg gggtgggtgg gtgggaaagg gatcctgaat ggtagaggcc aagtgagaat
     3361 tcggtttggt tttttgtttt gttttttttt ttctattttt tttcccaaaa agaaaaggga
     3421 ggggggaaag tgggtgcatt ttttaagctg tcttgaaata cctatttaaa tgtgtgtttt
     3481 ggttttttta ggattttttt ttaagctgcc tgtgatatgt ccgctgggct gagggtggag
     3541 acctcaggca ggagcccacc catagttctc tcttccctgt gaagacatcc ccagatagca
     3601 ttagccaccc tcggggggag ggggagaatc cggctatggg gaatccacct cgcccaagtc
     3661 tccttttatt gaaataaaat ttgaggggaa aagaaaaacc ttacacgagc accgaatttc
     3721 aaataaatga aaacgagaca tgaa
//
LOCUS       NM_001437938            9001 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 7, mRNA.
ACCESSION   NM_001437938 XM_017594793
VERSION     NM_001437938.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9001)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9001)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 9001)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 9001)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 9001)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 9001)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 9001)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 9001)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 9001)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 9001)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_017594793.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.814045.1,
                                           SRR26360190.1733068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000007.1  136229076-136229132 c
            58-161              JAXUCZ010000007.1  136228828-136228931 c
            162-344             JAXUCZ010000007.1  136227163-136227345 c
            345-531             JAXUCZ010000007.1  136218085-136218271 c
            532-632             JAXUCZ010000007.1  136213218-136213318 c
            633-9001            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..9001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..9001
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..57
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            58..161
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            162..344
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    184..186
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             208..783
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424867.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    262..411
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    262..411
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(262..273,322..324,328..330,361..363,373..393)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(262..273,322..324,328..330,361..363,373..393)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    553..726
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    553..726
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(580..582,586..600,622..624,649..651,709..711,
                     718..723)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(580..582,586..600,622..624,649..651,709..711,
                     718..723)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(592..594,706..714,718..723)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(592..594,706..714,718..723)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(676..678,688..693,697..702,709..714)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(676..678,688..693,697..702,709..714)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            345..531
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            532..632
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..9001
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccctcc tgttagccca gagggaaaga acgaactggg gcgatccggt aggtaaggca
       61 gggaaggcca tagccacaat gcttaactgc atgcttccaa catggggctg gttttaaccc
      121 agcgctctga cctaaagtgc tcagctcccg gaaattccaa ggaacctggt ggccgcactc
      181 ctttaggtgg accaacacat acccaacatg ggaaagaaga ccaagaggac agccgacagc
      241 tcttcatcag aggatgagga ggagtatgtg gtggaaaagg tgttggacag gcgcatggtt
      301 aaagggcaag tggagtatct gctgaagtgg aaaggctttt ctgaggagca caacacttgg
      361 gaacctgaga agaacttgga ttgtcctgaa ctaatttctg agtttatgaa aaagtacaag
      421 aagatgaagg agggagagaa caacaagcct agggagaagt cagaaggaaa caagaggaaa
      481 tccagttttt ccaacagtgc tgatgatatt aaatccaaaa aaaagagaga gcaaagcaat
      541 gatatcgctc ggggctttga gagaggactg gaaccagaaa agatcattgg ggcgacagat
      601 tcctgtggag acttaatgtt cttaatgaaa tggaaagaca cagatgaagc tgacctggtc
      661 cttgcaaaag aagctaatgt gaaatgtcca caaattgtga tagcatttta tgaagagaga
      721 ctgacgtggc atgcgtatcc agaggatgcg gaaaacaaag aaaaagaaag cgcaaagagc
      781 taaaggagga ggcagtctct gtcatttctc tttgtatata ataccttcac cttcctgcct
      841 cctctcgctt ctcccgtccc tttccatcct aaacatatcc ataaaaatga tgtgcttatc
      901 aatcactgtg ctccacggga gagatgttgg tattggttcc cttgtaatat aactgatggt
      961 ctgactccta agtgtagctc tgtgaaagtc aggcattaca tccttcacat gctgtgtggt
     1021 tcccatagtg ttctctttca tcctgatctt ttccttctgt tccctgtaac ttttaatcac
     1081 cttagagtcg tgatctttgg ggttggttgc tttggggaat tttattataa tgacgatgac
     1141 ttcagtttct tggttgttaa ttagaatata ttgatgacca gctggccttt gttttgacat
     1201 actggcatag aaaggatgtt gtccagcttt tagaaagcta atagcagcag cctacatgtt
     1261 gtgtattttt taatctcact tagctctgcc aggagaatac agggtccctg gtgtggtctt
     1321 ctgggccact cctgactatt ctcacctacc ctcccataac aactcagttc tcttgagggc
     1381 ttgagacttt acactgttta gccctcacac tcttttggct tcgttacttt caatccctga
     1441 ttctgcttct gtaaagtgta tcagtttgtt attaaatgac aggattaact gtggggtctg
     1501 taagctgtag tgcaggacga taacaggacg gggctggatg cggttgtctt tggtatcaca
     1561 tggtgtgcat gtgttctttc cttcaccctc attcctagac tctatttatg taggtgtagg
     1621 gactgcctgg tgcttgcttg tgccaagcac cctgccaact tttatggcct cccaaagcat
     1681 tcctgtacca aagaggaatc agcagatcca cacattccct tccgtgccgt tattttaagt
     1741 tgggaattgt tagaaaggaa ccattagcca cagtgtcatc agtttctaaa tcctcacagc
     1801 agtgatagat actctttaac tttaccacta agtccctaga ggattaatgt tcctgccctc
     1861 tccatcctca gacttttagt tgtagcttat tttaaaaact attttcatgg aagaccatcg
     1921 cctcagaaac caacaggtct tgacattagc tttttgacac aaccttctcc cacaacaaac
     1981 tactcctttt tgatttactc ttactttgct attatttctg ctcctgttct gttctttttg
     2041 tcccctgaaa atgtccatct tctcttcatt cctttcttct tatatagttg aggagactga
     2101 gaatcaggac taaatgtaag gaaataacag ggtttggagc tgagcactct tttttttttt
     2161 tttccccccc ccccggagct ggggaccgaa cccagggcct tgcgcttcct aggtaagcgc
     2221 tctaccactg agctaaatcc ccagccccag gagctgagca ctcttgaccc agctcaaaag
     2281 ctgaggaaaa ggagtaaacg ctgagatagc cttaattcta gactttatca actactgagg
     2341 ctgtttttgt tgttcctttc ggtttttaaa gcatagctat ctgagcagcc acccatttct
     2401 agatcgttca tggtaatgag gggaaggagt ggagtgctct ggtccacaga tgacccaagt
     2461 gtgtgcacgt cctagaccca ttcagtgttt gctagcatca cttctctgct cagctgccac
     2521 tgagctctgt gttcttgaat aaattatgtc aacaattata ctgcacagtt gacaggacag
     2581 ccaggaagaa cctgtgaatg gtactgtggt aggggaagag cacctaaccc ttacctctcc
     2641 gtagttcatt ctctgaagat ggtagaggca agctcaaagg ctggataagt gaccattgtc
     2701 tgcttaactt gatgaaatgc aggtggttag agagcagatg tgtccttcac gcaacctaga
     2761 ctagtaatta gggcagatga aggtagccca gaagtggccc agttcctgag gatcttagtc
     2821 tctgattagc agctggaggg aaggacagcc tgctgagcac tcagcagcag tgggctgtaa
     2881 actggcagtg gaaggactga gtatacagtt tgaggattta atgccttgta atgcaaaaaa
     2941 tgaagggaag gagtggcctg ctggttttaa tgctctttac aatgtttttc cctctcaaaa
     3001 gttcatggag tattggtttt ctgttaatta ttaccaaaac tctcttgtcc gtgtctcccc
     3061 cccccccccc ccagctgggg accgaaccca gggccttgcg cttgctaggc aagtgctcta
     3121 ccactgagct aaatccccaa ccccttgttt tcctcttagt aagtttcctg gttatatata
     3181 gaaataggga accgggattc cagtattctc ttcagctctc agtatgaaga agccagacac
     3241 ccatttgtgc ctccagcctg tgttgtgcca agtagcttga ttctgctgga gaattgcagc
     3301 tgtggacaaa agtgtttcct agagttatct tctatcttcg ctctaaagag ttcatggcca
     3361 aaggtgaaag aaatactcct aaacactgac tatattctcc tgtgttaacc ctctccagaa
     3421 ctaattttgt ggtactggaa attgaaccta ggaccagcgt ggacagccgg gcaactgctg
     3481 tgccattttt gtctgccccc tttcctcccc tgccatacag ttgatggatc accaaattca
     3541 cctgtttttg ttgctctaag gactttaagt cactgatacc aagctaacct tggttgtata
     3601 accaagttga attctttttt tttttttttt aaacttatgt gactatgttg ttgctgtctt
     3661 cagacacacc agaagaaggc atcggatcac attacagatg gttgtgagcc accatgtggt
     3721 tgctgggatt tgaactcagg acctctggaa gagcagtcag tgctcttaac cactgagcca
     3781 tcctccagcc ctgctaagtt gaattctttt tttctttttt tctttttctt tttctttttt
     3841 ccgaagctgg ggaccgaacc cagggccttg cgcttgctag gcaagcgctc taccactgag
     3901 ctaaatcccc aaccccctaa gttgaattct tgatctcctg cctcttccca gtctctagga
     3961 ttataggtat gtgccaccat atctggctct tagctccttc tatatggagt tatctgtgct
     4021 agccaggtac agtgtaatac acctttattt ccagtcttta ggaggcagaa gtagataaat
     4081 cttaatcgga ggcctgcctg gactatatag tgagttctag gccagccaca cctacataga
     4141 tcttgttgtg aaaggaaaaa taggaaaaga gtacccagat tggccttgaa cttaggatct
     4201 ttatgtatca gttgtatgcc actatgcctg gctcaaaatg cctttttttt tctttattaa
     4261 cttgagtatt tcttatttac atttcgattt tttttaagtt atatatatat gtgatttctg
     4321 cctgcatgta tatgcaccat atgcatgcct ggttccctag gagacagaag agggtctcat
     4381 atcctcttag ataggagtga gccactatgt gggtgttgag aatcagatct ggaagagtag
     4441 tcagtgctct taactgctga gccatctccc acccttcaaa acatctttct aaagttgaat
     4501 ttcttccccc cccccttttc tgtttagtcc tgactgtttc ttgctggctt caccctctag
     4561 tgctcacgtt ttgctagctt tgtgcaaaaa caggtgaact gggtgatcca tcctcaattt
     4621 tacacattgt gttgttcaca tttctacaac tttagcatac atcaatattg ttttcattca
     4681 acaaacagtt ttggctcagg aactcgctag agaactttga tagtggtgtg ggatgagttg
     4741 atcagtatag ttttggataa tgaatactgc acatgtatat aaattactgg tctgggacag
     4801 catcaggtat acaaaaaggt gagtctttag tgggcagtta gttaagtggt tgagtgctgg
     4861 tgaggaatcc atgaagccct gggtttccac gggggggggg gtaaggtaaa tctgcagtag
     4921 gagggggggg taaggtaaat ctgcagtagg aggggggggt aaggtaaatc tgcagtagga
     4981 gggtgccatt aactgcttca tctgtgggaa agactgtggt cttggatgaa ctgagttaac
     5041 tggccatggg cagcattgca ggaaataaag ctagaaaggc tttcgtttcg ttaccaagag
     5101 tgcagatgaa tgagcgtgag aactgtcttg tttagactgc caagcattca tgactgtgtt
     5161 agtattgcct gtgctggtgt atatttcttc tttgtgggcg ttttagcaag ttgctcacac
     5221 tgttcaattt ctcacccttt tggagaaatc aacattagtc tggctttaaa gcccaaaaca
     5281 taccatctaa tgacaagact tccttagaac aaagcttagg aatgagctac ctttggatca
     5341 cgtgggtctc agtgccaggg agtaagcagc tcctgtgtca cttatatcaa aaccttccac
     5401 aggaataatg tgctctggct cctcattgtg cgtgacaccc ttctcagaga aggaaaggtc
     5461 tgtttttcag gttcttattc tgactcctga gagcccaaga cgaagatgta attgactgac
     5521 tttagaagtc agaattccca gaaattcaac taactgctct agaaggttaa aatgtgaagt
     5581 ttcttgtttg ttttttgctt gtgctgaata ttttgaattt tcatctacct cgtcttattt
     5641 ttcttagtta cttctgtcat taccacttga gcatcaagct tgattttggt cattgtctaa
     5701 aatggggtct ctcctgttca gtgacagttt attcccttgt ctttcctctt ggccctcatt
     5761 tcacctaaca tcatctctta ttgctcctgt cagaaatatg ttttaaagtc ttgttttatg
     5821 ggaaaaagtg gtccaccaat gctgtttgtc tctgaggtca gtgagagaag gagttaaaac
     5881 acagtggtgg aggaagggca gagcctgcct gcactggagg caaaagctga caaggaagga
     5941 gtcattaatt aaagacaatt tcaaagtcaa ctgattgtga tcattaatgt cacaatagat
     6001 caaaacctaa ttatcacagc ctaggtaaga gccatcagta ttaatcggaa aatctaatag
     6061 gaaactatta gcaagaaatt aggccaaatt gaatgcaatg aactttttat catctttttt
     6121 tggtaatgtt cttggtgttg gcaactgtga ccctaacagt tggtccaagc ccagattgct
     6181 aattttaaag agcctttttt tttttttttt ttaagtaacc caggctgacc ctagtgctta
     6241 cagccctcca gcttcagcct tgagcactgg gattatgagg ggtacatgca tttgtgtttg
     6301 tgtgggtggg taggagagaa ttgaactcag ggccttgtac attttagaca agtgctctac
     6361 cactgaactg tattcctagc tcagagtgtt ttgtttgtta gggaagtttc cagacagact
     6421 gaacctaagc tgacattgct gaaacaccag ccttgaattt ttttatcata tggatctatt
     6481 cattctaatc agatcagcgg gatataaaca tatatattaa agtcgtagag tgtccctagt
     6541 gaacatcata tcatctgttg agtgcttgta tatagagttc tatactggtt gttgtgaagg
     6601 ctgtgggagg aaggcagtgt cctgctttga aattctttga aaactaaaaa gatagtttcc
     6661 ttgtgtgaca gcatgatcaa gatgcaagtc tgtgtttttc agtttccatt agcattaggg
     6721 tttgatccta aaccagctta gcagtgcccc caaccccaat agttttaaga taggcacaaa
     6781 atgatttcct actggaattc taaggtatgg ggaagacatc tttgtttctg ttttcctttc
     6841 tggtagtagg agaagcatca gtatgtcctt aagatgtttg taaagatgct acccccttta
     6901 ggtgagatga gtcaggctgt ggaacggttg ctgtcacagg aggagtgcca ggcagtagta
     6961 gagggaattg tgcttaggag tctgcactgt gccctgcagc cctcagatgc tcagtgctga
     7021 ccttaggagg cccatgctgc tttctggacc ttgggaacct ggattaccca gtagaagact
     7081 gagaatcaat gtcttttgtt tgtttgttta ttttttgttc tgtttttgtt ttgttttgtt
     7141 ttgttttcca agatggggtc tctgtgtagc catggatgtc ctggaacttg ctctgttgac
     7201 cagactggcc tcgaactcaa agatctgcct gcccctgcct cccaagtact gtgatcaaac
     7261 gtgtgcgcca tcactgcctg gctaaccctt cacttcttag tgagttttag tgtttaaaaa
     7321 atgcaactta attttcaaag tggcactaag gtggtttgtc cagccttggg ttactccagg
     7381 tgagcagcag ccctcaatta acagtgtgtt gattggactc atccggctgc agtgaaatga
     7441 ctgaaagtga gatgttctag tgcatagttc tgtgctaacc tcctacttgg tcttaatggc
     7501 tgaccttggg caagtctttc ctttcaatgc ctcagttccc catctgtcaa atggggtgat
     7561 aatactgacc tacctcatgg ggtgttgtga ggcattacag atcagagctg atcaaccctt
     7621 taggattgcc tgtggaggat accttaagtc ggactctttt agccctcact gagctacttc
     7681 caagtttgga agtagttagt gaccttggcg agtttctgtc cccccaccct ttacccctca
     7741 tcaaagctgc tagttcagat gttaacagtg ttttgtgaat gttggagtct tgatcgtcca
     7801 gtctaacttg ggacaatgta agggaaggca cttgtgggtt ctgtgtctta tattacaaag
     7861 agactgttag aaattcaaga gccttggttt aggaatcttg aggcaggaat gctaccgcat
     7921 gtctttctct gcaggagtta aggtcctatt ctcatggact tataactact tctgactgtc
     7981 ttcgaaagga agtgacactt ggtattttgg atttatattg ttgctttcat tttccagact
     8041 gatcctagga cagttagtct actgaaccct tcatgcttct atgcctctgc cctctcatag
     8101 aagccagatg gttcaagcaa catagctctc ccttccccca ccaaaaagct gtattggatt
     8161 tttgtttttt tgtttctaga aataggtgta acatttcaga attgagcatt ggtcctcaag
     8221 gcttcttcca gttcactgtg tgtggaatct gtcacctctt ttcagtgtcc accatctgac
     8281 ccactgagga catcttggac acttgtttgc ccacttgagg gttcaaaagc cttactctgt
     8341 gtttcagtat agggctaagg catccccaag ctcttcgtga taggtttcct ttcccctact
     8401 tgaccttgta ttggtaccat gaaaaagcac acagtcctag ctccctggag gtacacactc
     8461 cagtactgtt aggtggactc tactcctaac agggatccta gagggttctc tggaggatgg
     8521 gaaaggagca gtctcatgtc ctgccaagta gtagccagca gttgccttac ccctgcctgc
     8581 tggccatgtt cccacctcct catggagagg gctttcagag gtcctcgagg ctggattttc
     8641 tcagtctctg ctgtgccatt ctgagtggga agcagaccac actttgtggc caggtgtcta
     8701 agtggaagtg aggtcttgaa ttctcggtgg actttttggt ttgtggggga gttttggttg
     8761 tgtttcttgg ttctatttca gccaaactcg cctgcttttg atttctttaa aggataagtg
     8821 gtctatctat ctatatacat gtatgtttgc attttaagtg taaatgtttt gaaaaaaaaa
     8881 aacagacatg tctttctata actgacatcc gattcagaca tcattctctc cccttccacc
     8941 ctcttttccc tcttttcata ctcttgtatt ggttctaata aaggattgct tttcaaatat
     9001 g
//
LOCUS       NM_001437899            4205 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 3, mRNA.
ACCESSION   NM_001437899 XM_039078863
VERSION     NM_001437899.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4205)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078863.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.20662.1,
                                           SRR26643298.41658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-339             JAXUCZ010000007.1  122193494-122193621
            340-495             JAXUCZ010000007.1  122194723-122194878
            496-738             JAXUCZ010000007.1  122203808-122204050
            739-925             JAXUCZ010000007.1  122207498-122207684
            926-1063            JAXUCZ010000007.1  122210547-122210684
            1064-1129           JAXUCZ010000007.1  122213276-122213341
            1130-1242           JAXUCZ010000007.1  122216165-122216277
            1243-1356           JAXUCZ010000007.1  122216625-122216738
            1357-1483           JAXUCZ010000007.1  122218925-122219051
            1484-1636           JAXUCZ010000007.1  122220112-122220264
            1637-1852           JAXUCZ010000007.1  122223641-122223856
            1853-1917           JAXUCZ010000007.1  122225088-122225152
            1918-2033           JAXUCZ010000007.1  122226909-122227024
            2034-2119           JAXUCZ010000007.1  122228286-122228371
            2120-2200           JAXUCZ010000007.1  122228849-122228929
            2201-2298           JAXUCZ010000007.1  122229298-122229395
            2299-2356           JAXUCZ010000007.1  122229728-122229785
            2357-2478           JAXUCZ010000007.1  122230077-122230198
            2479-2642           JAXUCZ010000007.1  122230444-122230607
            2643-2799           JAXUCZ010000007.1  122231523-122231679
            2800-2888           JAXUCZ010000007.1  122231770-122231858
            2889-3084           JAXUCZ010000007.1  122232571-122232766
            3085-3312           JAXUCZ010000007.1  122235416-122235643
            3313-4205           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4205
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..339
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    317..319
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            340..495
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..738
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..3361
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 1"
                     /protein_id="NP_001424828.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLVSTHHLHSSSEDEDIEGTFPNELSLQQAFS
                     EYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIEADEDSPSAALFEAC
                     CSDRIQPFDDDEEDIWEDEETRCTARVMARARFGAPHTSENYSKKAVGHGGQGRKTGS
                     PTARNVPGLATPSSPTQKEGPRSESDSAGTTWTAVFDEPVNPLSAASGAARDVGSSAW
                     AAGPSVAEEKGWAKFTDFQPFCCSETGPRCSSPVDMDHSNAEGGQSPGPEKAFGPTSP
                     CAWNVCVTRKAPLVASDSSSSGGSDSEDDEKAAGAVEALCAGHTGKASPPPRTAEAAA
                     GRAECPDSTVLAPACPAPSEVTISPAVATIAPSKAGSPTATIVVSSSVATAVPPGPIM
                     AVTTTAPAIVATLGTMTKDRKTDALPDGAALNGPV"
     misc_feature    893..2113
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    893..2113
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2444..>3331
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2444..>3331
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            739..925
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1063
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1129
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1242
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1356
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1483
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1636
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1852
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1917
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2033
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2119
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2200
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2298
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2356
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2478
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2642
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2799
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2888
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3084
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3312
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..4205
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggtaaaccaa ccaaaactct ttgcagaatg
      241 aaaacacctt ttttaaaatt gcatgtatac aaaagaaaga gcccaaatgc tttttatttt
      301 gcctgaatac aagatttaaa caaggtattg ccatagaagt ctctaccaca gcgcgttctg
      361 ttggactctt tcacggaact ataggatcac atgggcagca cttgtgtttg attctaccct
      421 ctttcttccg gtcggttctg tcaccctggg aaatagagaa gcagaacgta cggctccttt
      481 cttcattcac tgctgctctg tgaccaccat catgttctgg aaatttgact tgaataccac
      541 gtcccacgtt gacaagctcc tcgacaagga acatgtgaca ctgcaggaat taatggatga
      601 agatgacatc ttgcaagagt gtaaggctca gaaccagaag ctgctggact tcctgtgcag
      661 gcagcagtgt atggaggagc tggtgaacct catcacacaa gacccacccc aggacatgga
      721 agagaaggtc cgattcaaat atccaaacac agcctgtgag cttctgactt gtgatgtgcc
      781 gcagatcagc gacagactag gcgaggacga gagtctgctg aaccttctgt atgacttctt
      841 ggaccaggag ccaccactca accctctgct tgccagtttt tttagcaaga ccattggcaa
      901 tctcattgca aggaaaaccg aacaggtgat catgttcttg aagaagaagg acaagttcat
      961 cagtctgata ctgaagcaca taggcacctc agctctcatg gacctgctgc tacgcctggt
     1021 cagctgcgtg gaaccagttg ttctccggca ggaggtccta cattggctta atgaagagaa
     1081 agtcatccag agacttgtgg aattgatcca tccccaccag gatgaagata ggcagtcaaa
     1141 tgcttctcag gcactctgtg acatcatcag gctgggcaga gaccagggca gtcagctgca
     1201 ggagactgtg gagccggatc ccctcctcac agcactggag tcgcaggact gtgtggaaca
     1261 gcttctgaag aacatgtttg atggggatcg gacggagagc tgcctggtca gtgggatgca
     1321 ggtgctgctt gccctgctgg agccaaggcg tgttggaaca gaaggcttgg tggactcctt
     1381 ttctcaggga ctggaaaggt catactctgt cagcagcagc atcctgcacg gcattgagcc
     1441 atggctgaag aatttccatc agctcctgct caacccacca aagaagaaag caatcctgac
     1501 cactattggc gtgctagagg agcccctggg gaatgctcgt cttcatggtg cacgcctcat
     1561 ggctgcactg ctgcacacaa atacgcccag catcaaccag gagctctgcc ggctcaacac
     1621 catggactta ctgctggacc tgttttttaa gtacacctgg aataacttct tacacttgca
     1681 agtggagctg tgcatagccg ctattctctc ccacgctggt cgggaggagc aggcagaagc
     1741 tggcagatca gatggcaaag tggaacctgt gcaggggagt ggagatgggg gtgggaagcc
     1801 ggagaccacc ccgtccatca ccagccctcc tgagaacaca atggtgaccc atctgttcca
     1861 gaagtgctgc ctggttcaga ggatcctgga agcctgggaa gccaatgaca acacacaggc
     1921 ggcaggtggc atgagacgtg ggaatatggg ccacctcaca aggatcgcca acgcagttgt
     1981 acagaacctg gagcagggcc cggtgcagac acacatcagt gaagtcatcc gagggctccc
     2041 tgcagagtgc cgtggacgct gggagagctt tgtggaagag acactgatgg agaccaaccg
     2101 caggaacact gtggacctgg tgagcactca ccaccttcac tcctcaagtg aggacgagga
     2161 cattgagggt actttcccta acgagctgtc ccttcagcag gccttctctg agtaccagat
     2221 ccagcagatg acagcaaact ttgtggatca gtttggcttc aatgatgagg agtttgcaga
     2281 ccaggatgac aacatcaatg ccccatttga ccggattgca gagatcaact tcaacattga
     2341 agccgatgag gacagtccca gtgcagctct gtttgaagct tgctgcagtg atcggatcca
     2401 gcccttcgat gatgacgagg aggacatttg ggaggatgag gagactcgat gcacggcccg
     2461 ggtgatggcc agagccaggt ttggagcccc tcacacctca gaaaactact caaagaaggc
     2521 cgtgggacat ggaggccagg gcaggaagac tggctccccc acagctagga atgtgcctgg
     2581 actggccacg ccttcatccc ctacacagaa agaaggtcct cgctcagaaa gtgattcagc
     2641 aggtactaca tggacagcag tttttgatga gccagtgaac ccgctgtctg cagcctcagg
     2701 agctgcgagg gatgtgggtt ctagtgcatg ggcggctggt ccttcagttg cagaggagaa
     2761 aggctgggcc aaattcaccg acttccagcc tttctgctgc tctgagacag ggccccggtg
     2821 cagctctcct gtggacatgg accacagcaa tgccgagggt ggccagagtc caggcccaga
     2881 gaaagccttt ggtcctacct cgccttgtgc ctggaacgtg tgtgtcacta ggaaggcccc
     2941 actggtagcc tctgacagca gctcctctgg gggatctgac agtgaagatg acgagaaggc
     3001 agcgggtgct gtggaagctc tgtgcgcagg ccatactgga aaggcctccc cgccacccag
     3061 gacagcagag gctgctgctg gcagggccga gtgtcctgac agcaccgtgt tagcccctgc
     3121 ctgccctgct ccttcagaag tgaccatcag tcctgccgtg gctaccatag caccaagcaa
     3181 ggcaggctct cccacagcca ccatagtggt ctcttcctca gtggctactg cggtaccccc
     3241 aggaccaatc atggcagtaa ccacaacagc tccagccata gttgcaaccc tggggacaat
     3301 gacaaaggac aggaagacag atgccctgcc agatggagct gccttaaatg gccctgtgta
     3361 atggctgccg cccagctatg gcccaccctg gtcaggctgc ctccttaatc aagaagacta
     3421 cctggtgatg caattttttt taatttaact ttaaaataaa tgctgcattt ggtaaagctg
     3481 gcagtggaac ccgttggatg acccagctca tgtttctcct gcctgccctt ggtcctgttg
     3541 gaggacagga tgcacctggc cattcccagg cccaggtctt ggtgtggcaa tgcagccctg
     3601 acgcgcagct tcaacctgca ggagttgggg agggaacaag accctaaggg gccagcacca
     3661 tcggatgggc aggaagggtg cggatctcca ggcgctggtt tcatctgtat ttttaacgca
     3721 tggaggaaaa gccgtttttt gcactttgta cccagctaca gtacagggtc tctctaggct
     3781 cagggcagat gtacaggcct gagttggaga gacctgatcc ccactaataa tactacatgg
     3841 gggtctggca ctagtttggc cacatgaggt caaaccccag ttctagctgc ccagggactc
     3901 ctgggagctg gtgttgaatc aggctacaca ttttgactgc cttaaaaaca aagaccctct
     3961 ggacccggtg cagtggtctc tgtgctcagc agggcagact ggcacactcg ggtgggggtt
     4021 ggagctgcac cagacatgta agagtggaca cggaagagca ctgggaggcc tagggaccgg
     4081 gcgggcccat agtgtccagg aagagtctaa agtctatgtt gtcttttttt tttttttttt
     4141 ttaaatgttc tgaccttctg acagggcatc taacccccaa taaaaaggat cattcttact
     4201 gaaaa
//
LOCUS       NM_001106797            8997 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 2, mRNA.
ACCESSION   NM_001106797 XM_001069676 XM_217062
VERSION     NM_001106797.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8997)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8997)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 8997)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 8997)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 8997)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 8997)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8997)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8997)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 8997)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 8997)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001106797.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168739.1, FM071446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000007.1  136229076-136229132 c
            58-157              JAXUCZ010000007.1  136228828-136228927 c
            158-340             JAXUCZ010000007.1  136227163-136227345 c
            341-527             JAXUCZ010000007.1  136218085-136218271 c
            528-628             JAXUCZ010000007.1  136213218-136213318 c
            629-8997            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..8997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..8997
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..57
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            58..157
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            158..340
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    180..182
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             204..779
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001100267.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    258..407
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    258..407
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(258..269,318..320,324..326,357..359,369..389)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(258..269,318..320,324..326,357..359,369..389)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    549..722
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    549..722
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(576..578,582..596,618..620,645..647,705..707,
                     714..719)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(576..578,582..596,618..620,645..647,705..707,
                     714..719)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(588..590,702..710,714..719)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(588..590,702..710,714..719)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(672..674,684..689,693..698,705..710)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(672..674,684..689,693..698,705..710)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            341..527
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            528..628
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            629..8997
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcccctcc tgttagccca gagggaaaga acgaactggg gcgatccggt aggtaaggga
       61 aggccatagc cacaatgctt aactgcatgc ttccaacatg gggctggttt taacccagcg
      121 ctctgaccta aagtgctcag ctcccggaaa ttccaaggaa cctggtggcc gcactccttt
      181 aggtggacca acacataccc aacatgggaa agaagaccaa gaggacagcc gacagctctt
      241 catcagagga tgaggaggag tatgtggtgg aaaaggtgtt ggacaggcgc atggttaaag
      301 ggcaagtgga gtatctgctg aagtggaaag gcttttctga ggagcacaac acttgggaac
      361 ctgagaagaa cttggattgt cctgaactaa tttctgagtt tatgaaaaag tacaagaaga
      421 tgaaggaggg agagaacaac aagcctaggg agaagtcaga aggaaacaag aggaaatcca
      481 gtttttccaa cagtgctgat gatattaaat ccaaaaaaaa gagagagcaa agcaatgata
      541 tcgctcgggg ctttgagaga ggactggaac cagaaaagat cattggggcg acagattcct
      601 gtggagactt aatgttctta atgaaatgga aagacacaga tgaagctgac ctggtccttg
      661 caaaagaagc taatgtgaaa tgtccacaaa ttgtgatagc attttatgaa gagagactga
      721 cgtggcatgc gtatccagag gatgcggaaa acaaagaaaa agaaagcgca aagagctaaa
      781 ggaggaggca gtctctgtca tttctctttg tatataatac cttcaccttc ctgcctcctc
      841 tcgcttctcc cgtccctttc catcctaaac atatccataa aaatgatgtg cttatcaatc
      901 actgtgctcc acgggagaga tgttggtatt ggttcccttg taatataact gatggtctga
      961 ctcctaagtg tagctctgtg aaagtcaggc attacatcct tcacatgctg tgtggttccc
     1021 atagtgttct ctttcatcct gatcttttcc ttctgttccc tgtaactttt aatcacctta
     1081 gagtcgtgat ctttggggtt ggttgctttg gggaatttta ttataatgac gatgacttca
     1141 gtttcttggt tgttaattag aatatattga tgaccagctg gcctttgttt tgacatactg
     1201 gcatagaaag gatgttgtcc agcttttaga aagctaatag cagcagccta catgttgtgt
     1261 attttttaat ctcacttagc tctgccagga gaatacaggg tccctggtgt ggtcttctgg
     1321 gccactcctg actattctca cctaccctcc cataacaact cagttctctt gagggcttga
     1381 gactttacac tgtttagccc tcacactctt ttggcttcgt tactttcaat ccctgattct
     1441 gcttctgtaa agtgtatcag tttgttatta aatgacagga ttaactgtgg ggtctgtaag
     1501 ctgtagtgca ggacgataac aggacggggc tggatgcggt tgtctttggt atcacatggt
     1561 gtgcatgtgt tctttccttc accctcattc ctagactcta tttatgtagg tgtagggact
     1621 gcctggtgct tgcttgtgcc aagcaccctg ccaactttta tggcctccca aagcattcct
     1681 gtaccaaaga ggaatcagca gatccacaca ttcccttccg tgccgttatt ttaagttggg
     1741 aattgttaga aaggaaccat tagccacagt gtcatcagtt tctaaatcct cacagcagtg
     1801 atagatactc tttaacttta ccactaagtc cctagaggat taatgttcct gccctctcca
     1861 tcctcagact tttagttgta gcttatttta aaaactattt tcatggaaga ccatcgcctc
     1921 agaaaccaac aggtcttgac attagctttt tgacacaacc ttctcccaca acaaactact
     1981 cctttttgat ttactcttac tttgctatta tttctgctcc tgttctgttc tttttgtccc
     2041 ctgaaaatgt ccatcttctc ttcattcctt tcttcttata tagttgagga gactgagaat
     2101 caggactaaa tgtaaggaaa taacagggtt tggagctgag cactcttttt tttttttttc
     2161 cccccccccc ggagctgggg accgaaccca gggccttgcg cttcctaggt aagcgctcta
     2221 ccactgagct aaatccccag ccccaggagc tgagcactct tgacccagct caaaagctga
     2281 ggaaaaggag taaacgctga gatagcctta attctagact ttatcaacta ctgaggctgt
     2341 ttttgttgtt cctttcggtt tttaaagcat agctatctga gcagccaccc atttctagat
     2401 cgttcatggt aatgagggga aggagtggag tgctctggtc cacagatgac ccaagtgtgt
     2461 gcacgtccta gacccattca gtgtttgcta gcatcacttc tctgctcagc tgccactgag
     2521 ctctgtgttc ttgaataaat tatgtcaaca attatactgc acagttgaca ggacagccag
     2581 gaagaacctg tgaatggtac tgtggtaggg gaagagcacc taacccttac ctctccgtag
     2641 ttcattctct gaagatggta gaggcaagct caaaggctgg ataagtgacc attgtctgct
     2701 taacttgatg aaatgcaggt ggttagagag cagatgtgtc cttcacgcaa cctagactag
     2761 taattagggc agatgaaggt agcccagaag tggcccagtt cctgaggatc ttagtctctg
     2821 attagcagct ggagggaagg acagcctgct gagcactcag cagcagtggg ctgtaaactg
     2881 gcagtggaag gactgagtat acagtttgag gatttaatgc cttgtaatgc aaaaaatgaa
     2941 gggaaggagt ggcctgctgg ttttaatgct ctttacaatg tttttccctc tcaaaagttc
     3001 atggagtatt ggttttctgt taattattac caaaactctc ttgtccgtgt ctcccccccc
     3061 ccccccccag ctggggaccg aacccagggc cttgcgcttg ctaggcaagt gctctaccac
     3121 tgagctaaat ccccaacccc ttgttttcct cttagtaagt ttcctggtta tatatagaaa
     3181 tagggaaccg ggattccagt attctcttca gctctcagta tgaagaagcc agacacccat
     3241 ttgtgcctcc agcctgtgtt gtgccaagta gcttgattct gctggagaat tgcagctgtg
     3301 gacaaaagtg tttcctagag ttatcttcta tcttcgctct aaagagttca tggccaaagg
     3361 tgaaagaaat actcctaaac actgactata ttctcctgtg ttaaccctct ccagaactaa
     3421 ttttgtggta ctggaaattg aacctaggac cagcgtggac agccgggcaa ctgctgtgcc
     3481 atttttgtct gccccctttc ctcccctgcc atacagttga tggatcacca aattcacctg
     3541 tttttgttgc tctaaggact ttaagtcact gataccaagc taaccttggt tgtataacca
     3601 agttgaattc tttttttttt ttttttaaac ttatgtgact atgttgttgc tgtcttcaga
     3661 cacaccagaa gaaggcatcg gatcacatta cagatggttg tgagccacca tgtggttgct
     3721 gggatttgaa ctcaggacct ctggaagagc agtcagtgct cttaaccact gagccatcct
     3781 ccagccctgc taagttgaat tctttttttc tttttttctt tttctttttc ttttttccga
     3841 agctggggac cgaacccagg gccttgcgct tgctaggcaa gcgctctacc actgagctaa
     3901 atccccaacc ccctaagttg aattcttgat ctcctgcctc ttcccagtct ctaggattat
     3961 aggtatgtgc caccatatct ggctcttagc tccttctata tggagttatc tgtgctagcc
     4021 aggtacagtg taatacacct ttatttccag tctttaggag gcagaagtag ataaatctta
     4081 atcggaggcc tgcctggact atatagtgag ttctaggcca gccacaccta catagatctt
     4141 gttgtgaaag gaaaaatagg aaaagagtac ccagattggc cttgaactta ggatctttat
     4201 gtatcagttg tatgccacta tgcctggctc aaaatgcctt tttttttctt tattaacttg
     4261 agtatttctt atttacattt cgattttttt taagttatat atatatgtga tttctgcctg
     4321 catgtatatg caccatatgc atgcctggtt ccctaggaga cagaagaggg tctcatatcc
     4381 tcttagatag gagtgagcca ctatgtgggt gttgagaatc agatctggaa gagtagtcag
     4441 tgctcttaac tgctgagcca tctcccaccc ttcaaaacat ctttctaaag ttgaatttct
     4501 tccccccccc cttttctgtt tagtcctgac tgtttcttgc tggcttcacc ctctagtgct
     4561 cacgttttgc tagctttgtg caaaaacagg tgaactgggt gatccatcct caattttaca
     4621 cattgtgttg ttcacatttc tacaacttta gcatacatca atattgtttt cattcaacaa
     4681 acagttttgg ctcaggaact cgctagagaa ctttgatagt ggtgtgggat gagttgatca
     4741 gtatagtttt ggataatgaa tactgcacat gtatataaat tactggtctg ggacagcatc
     4801 aggtatacaa aaaggtgagt ctttagtggg cagttagtta agtggttgag tgctggtgag
     4861 gaatccatga agccctgggt ttccacgggg gggggggtaa ggtaaatctg cagtaggagg
     4921 ggggggtaag gtaaatctgc agtaggaggg gggggtaagg taaatctgca gtaggagggt
     4981 gccattaact gcttcatctg tgggaaagac tgtggtcttg gatgaactga gttaactggc
     5041 catgggcagc attgcaggaa ataaagctag aaaggctttc gtttcgttac caagagtgca
     5101 gatgaatgag cgtgagaact gtcttgttta gactgccaag cattcatgac tgtgttagta
     5161 ttgcctgtgc tggtgtatat ttcttctttg tgggcgtttt agcaagttgc tcacactgtt
     5221 caatttctca cccttttgga gaaatcaaca ttagtctggc tttaaagccc aaaacatacc
     5281 atctaatgac aagacttcct tagaacaaag cttaggaatg agctaccttt ggatcacgtg
     5341 ggtctcagtg ccagggagta agcagctcct gtgtcactta tatcaaaacc ttccacagga
     5401 ataatgtgct ctggctcctc attgtgcgtg acacccttct cagagaagga aaggtctgtt
     5461 tttcaggttc ttattctgac tcctgagagc ccaagacgaa gatgtaattg actgacttta
     5521 gaagtcagaa ttcccagaaa ttcaactaac tgctctagaa ggttaaaatg tgaagtttct
     5581 tgtttgtttt ttgcttgtgc tgaatatttt gaattttcat ctacctcgtc ttatttttct
     5641 tagttacttc tgtcattacc acttgagcat caagcttgat tttggtcatt gtctaaaatg
     5701 gggtctctcc tgttcagtga cagtttattc ccttgtcttt cctcttggcc ctcatttcac
     5761 ctaacatcat ctcttattgc tcctgtcaga aatatgtttt aaagtcttgt tttatgggaa
     5821 aaagtggtcc accaatgctg tttgtctctg aggtcagtga gagaaggagt taaaacacag
     5881 tggtggagga agggcagagc ctgcctgcac tggaggcaaa agctgacaag gaaggagtca
     5941 ttaattaaag acaatttcaa agtcaactga ttgtgatcat taatgtcaca atagatcaaa
     6001 acctaattat cacagcctag gtaagagcca tcagtattaa tcggaaaatc taataggaaa
     6061 ctattagcaa gaaattaggc caaattgaat gcaatgaact ttttatcatc tttttttggt
     6121 aatgttcttg gtgttggcaa ctgtgaccct aacagttggt ccaagcccag attgctaatt
     6181 ttaaagagcc tttttttttt ttttttttaa gtaacccagg ctgaccctag tgcttacagc
     6241 cctccagctt cagccttgag cactgggatt atgaggggta catgcatttg tgtttgtgtg
     6301 ggtgggtagg agagaattga actcagggcc ttgtacattt tagacaagtg ctctaccact
     6361 gaactgtatt cctagctcag agtgttttgt ttgttaggga agtttccaga cagactgaac
     6421 ctaagctgac attgctgaaa caccagcctt gaattttttt atcatatgga tctattcatt
     6481 ctaatcagat cagcgggata taaacatata tattaaagtc gtagagtgtc cctagtgaac
     6541 atcatatcat ctgttgagtg cttgtatata gagttctata ctggttgttg tgaaggctgt
     6601 gggaggaagg cagtgtcctg ctttgaaatt ctttgaaaac taaaaagata gtttccttgt
     6661 gtgacagcat gatcaagatg caagtctgtg tttttcagtt tccattagca ttagggtttg
     6721 atcctaaacc agcttagcag tgcccccaac cccaatagtt ttaagatagg cacaaaatga
     6781 tttcctactg gaattctaag gtatggggaa gacatctttg tttctgtttt cctttctggt
     6841 agtaggagaa gcatcagtat gtccttaaga tgtttgtaaa gatgctaccc cctttaggtg
     6901 agatgagtca ggctgtggaa cggttgctgt cacaggagga gtgccaggca gtagtagagg
     6961 gaattgtgct taggagtctg cactgtgccc tgcagccctc agatgctcag tgctgacctt
     7021 aggaggccca tgctgctttc tggaccttgg gaacctggat tacccagtag aagactgaga
     7081 atcaatgtct tttgtttgtt tgtttatttt ttgttctgtt tttgttttgt tttgttttgt
     7141 tttccaagat ggggtctctg tgtagccatg gatgtcctgg aacttgctct gttgaccaga
     7201 ctggcctcga actcaaagat ctgcctgccc ctgcctccca agtactgtga tcaaacgtgt
     7261 gcgccatcac tgcctggcta acccttcact tcttagtgag ttttagtgtt taaaaaatgc
     7321 aacttaattt tcaaagtggc actaaggtgg tttgtccagc cttgggttac tccaggtgag
     7381 cagcagccct caattaacag tgtgttgatt ggactcatcc ggctgcagtg aaatgactga
     7441 aagtgagatg ttctagtgca tagttctgtg ctaacctcct acttggtctt aatggctgac
     7501 cttgggcaag tctttccttt caatgcctca gttccccatc tgtcaaatgg ggtgataata
     7561 ctgacctacc tcatggggtg ttgtgaggca ttacagatca gagctgatca accctttagg
     7621 attgcctgtg gaggatacct taagtcggac tcttttagcc ctcactgagc tacttccaag
     7681 tttggaagta gttagtgacc ttggcgagtt tctgtccccc caccctttac ccctcatcaa
     7741 agctgctagt tcagatgtta acagtgtttt gtgaatgttg gagtcttgat cgtccagtct
     7801 aacttgggac aatgtaaggg aaggcacttg tgggttctgt gtcttatatt acaaagagac
     7861 tgttagaaat tcaagagcct tggtttagga atcttgaggc aggaatgcta ccgcatgtct
     7921 ttctctgcag gagttaaggt cctattctca tggacttata actacttctg actgtcttcg
     7981 aaaggaagtg acacttggta ttttggattt atattgttgc tttcattttc cagactgatc
     8041 ctaggacagt tagtctactg aacccttcat gcttctatgc ctctgccctc tcatagaagc
     8101 cagatggttc aagcaacata gctctccctt cccccaccaa aaagctgtat tggatttttg
     8161 tttttttgtt tctagaaata ggtgtaacat ttcagaattg agcattggtc ctcaaggctt
     8221 cttccagttc actgtgtgtg gaatctgtca cctcttttca gtgtccacca tctgacccac
     8281 tgaggacatc ttggacactt gtttgcccac ttgagggttc aaaagcctta ctctgtgttt
     8341 cagtataggg ctaaggcatc cccaagctct tcgtgatagg tttcctttcc cctacttgac
     8401 cttgtattgg taccatgaaa aagcacacag tcctagctcc ctggaggtac acactccagt
     8461 actgttaggt ggactctact cctaacaggg atcctagagg gttctctgga ggatgggaaa
     8521 ggagcagtct catgtcctgc caagtagtag ccagcagttg ccttacccct gcctgctggc
     8581 catgttccca cctcctcatg gagagggctt tcagaggtcc tcgaggctgg attttctcag
     8641 tctctgctgt gccattctga gtgggaagca gaccacactt tgtggccagg tgtctaagtg
     8701 gaagtgaggt cttgaattct cggtggactt tttggtttgt gggggagttt tggttgtgtt
     8761 tcttggttct atttcagcca aactcgcctg cttttgattt ctttaaagga taagtggtct
     8821 atctatctat atacatgtat gtttgcattt taagtgtaaa tgttttgaaa aaaaaaaaca
     8881 gacatgtctt tctataactg acatccgatt cagacatcat tctctcccct tccaccctct
     8941 tttccctctt ttcatactct tgtattggtt ctaataaagg attgcttttc aaatatg
//
LOCUS       NM_001437971            2905 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RIC8 guanine nucleotide exchange factor B
            (Ric8b), transcript variant 3, mRNA.
ACCESSION   NM_001437971 XM_063263436
VERSION     NM_001437971.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Lopez-Benito,S., Lillo,C., Hernandez-Hernandez,A., Chao,M.V. and
            Arevalo,J.C.
  TITLE     ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated
            secretion
  JOURNAL   J Cell Sci 129 (9), 1866-1877 (2016)
   PUBMED   26966186
  REMARK    GeneRIF: overexpression of ARMS blocked NGF-mediated secretion,
            without affecting basal secretion, a decrease in ARMS resulted in
            potentiation. Similar effects were observed with synembryn-B, a
            protein that interacts directly with ARMS. Downstream of ARMS and
            synembryn-B are Galphaq and Trio proteins, which modulate the
            activity of Rac1 in response to NGF
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Aguilar,R., Grandy,R., Meza,D., Sepulveda,H., Pihan,P., van
            Wijnen,A.J., Lian,J.B., Stein,G.S., Stein,J.L. and Montecino,M.
  TITLE     A functional N-terminal domain in C/EBPbeta-LAP* is required for
            interacting with SWI/SNF and to repress Ric-8B gene transcription
            in osteoblasts
  JOURNAL   J Cell Physiol 229 (10), 1521-1528 (2014)
   PUBMED   24585571
  REMARK    GeneRIF: Results indicate that a functional N-terminus in
            C/EBPbeta-LAP* is required for interacting with SWI/SNF and for
            Ric-8B gene repression in osteoblasts.
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Chan,P., Gabay,M., Wright,F.A. and Tall,G.G.
  TITLE     Ric-8B is a GTP-dependent G protein alphas guanine nucleotide
            exchange factor
  JOURNAL   J Biol Chem 286 (22), 19932-19942 (2011)
   PUBMED   21467038
  REMARK    GeneRIF: Ric-8BFL-catalyzed nucleotide exchange probably proceeds
            in the forward direction to produce Galpha-GTP in cells.
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Klattenhoff,C., Montecino,M., Soto,X., Guzman,L., Romo,X.,
            Garcia,M.A., Mellstrom,B., Naranjo,J.R., Hinrichs,M.V. and Olate,J.
  TITLE     Human brain synembryn interacts with Gsalpha and Gqalpha and is
            translocated to the plasma membrane in response to isoproterenol
            and carbachol
  JOURNAL   J Cell Physiol 195 (2), 151-157 (2003)
   PUBMED   12652642
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Tall,G.G., Krumins,A.M. and Gilman,A.G.
  TITLE     Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein
            guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 278 (10), 8356-8362 (2003)
   PUBMED   12509430
  REMARK    GeneRIF: two mammalian homologs of the Caenorhabditis elegans
            protein Ric-8 were identified: Ric-8A (Ric-8/synembryn) and Ric-8B
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263436.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.19206.1,
                                           SRR26643295.27520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000007.1  20729896-20730066   c
            172-219             JAXUCZ010000007.1  20722480-20722527   c
            220-828             JAXUCZ010000007.1  20701536-20702144   c
            829-923             JAXUCZ010000007.1  20691843-20691937   c
            924-1152            JAXUCZ010000007.1  20678508-20678736   c
            1153-1297           JAXUCZ010000007.1  20669149-20669293   c
            1298-1442           JAXUCZ010000007.1  20658000-20658144   c
            1443-2905           JAXUCZ010000007.1  20636337-20637799   c
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2905
                     /gene="Ric8b"
                     /note="RIC8 guanine nucleotide exchange factor B"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
     exon            1..171
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1554
                     /gene="Ric8b"
                     /note="isoform 3 is encoded by transcript variant 3;
                     synembryn-B; resistance to inhibitors of cholinesterase 8
                     homolog B; resistance to inhibitors of cholinesterase 8B;
                     heterotrimeric G protein guanine nucleotide exchange
                     factor-like protein Ric-8B; chaperone Ric-8B"
                     /codon_start=1
                     /product="chaperone Ric-8B isoform 3"
                     /protein_id="NP_001424900.1"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
                     /translation="MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESADEDKRK
                     KLCEGIFKVLVKGVPTTCQVPCLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESD
                     DSLEKVSEFPVIVESLKCLCNIVFNSQVAQQLSLELNLAAKLCNLLRKCKDRKFINDI
                     KCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHSGPP
                     LSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEE
                     LHSNAVNLLSNVPVSCLDVLICPLTHEETAQEAATLDELPGDKTAEKDTALKSSAMVY
                     NGMNMEAIHVLLSFMEKRIDKVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIA
                     AEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAK
                     PKEELLKPMGLKPDGTITPLEEALSQYSVIEETSSDTD"
     misc_feature    283..1440
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     misc_feature    283..1440
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     exon            172..219
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            220..828
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..923
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1152
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1297
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1442
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..2905
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggtag cgggggcgcg aggcgtttac ctgggaggca gcggctgggg cgcgcacagc
       61 ggctgcggct cccccgcacc tgcggccatg gatgaagagc gcgccctcta catcgtccgg
      121 gccggcgagg cgggggctat cgagcgggtc ctgagagatt acagcgacaa gcatagggct
      181 actttcaaat ttgaatcagc agatgaagat aaaagaaaga aactctgtga aggcatattt
      241 aaggtcctgg taaagggtgt cccaacaaca tgccaagtgc cctgcctgga agttctccgc
      301 attctctcca gagacaaaaa gattttagct cctgtaacaa ctgaggaaaa tatgcaaata
      361 ctgctgagac tggccaagct ccatgagtcg gacgattctt tggagaaggt gtcagagttc
      421 ccggtcattg tggagtcatt gaaatgtctt tgtaacatcg tgttcaacag tcaggtggca
      481 cagcagctta gcctggaact gaatctcgct gcaaagctct gtaacctcct gaggaagtgc
      541 aaggaccgaa aatttatcaa tgacataaag tgctttgacc tgcgcttgct ctttgtcctg
      601 tcacttttgc acactgacat caggtcacaa ttgcgctatg agctccaggg actgccgctg
      661 ctaacccaga tcttggaaag tgcctttagc atcaagtgga ccgatgagta tgagtcggcc
      721 atagaccata gtggacctcc tctctcacct caggagacag actgtgccat tgaggccctc
      781 aaagctctgt tcaatgtgac ggtagacagt tggaaggtgc ataaagagag cgattctcat
      841 cagttccgtg tcatggccgc tgtccttcgc cactgtttac taattgtagg tccaaccgaa
      901 gacaaaacgg aagagctgca cagtaatgcc gtcaaccttt taagcaatgt tccagtctct
      961 tgtttggatg ttctcatttg tccattaacc catgaagaaa cagcccagga ggcagcaact
     1021 ctagacgaac tgcccggtga taagacagca gagaaagaca cggctttgaa gagcagtgcc
     1081 atggtataca atggcatgaa catggaggcc atccacgttt tactcagttt tatggagaag
     1141 aggattgata aggtgttacc acctttgagg gatgtgacaa atcgaccaga agtcggctca
     1201 accgtgagaa ataagctggt gcgcctcatg acacacgttg acctcggagt caagcagatt
     1261 gctgctgagt tcctcttcgt cctttgcaaa gagcgagtgg atagtctgct gaagtacact
     1321 ggctatggga acgctgcagg actgctggct gccaggggcc tcttggctgg aggaagagga
     1381 gacaattggt actcagagga cgaggacacg gacactgagg aatacaaaaa cgcaaaacca
     1441 aaagaggagt tgcttaaacc aatgggacta aaacctgacg ggacaataac gcctttggag
     1501 gaagcgctca gccagtattc tgtcatcgaa gagaccagct cggacacaga ctgaaagcgc
     1561 cgtcacctgc tccctctcaa tatggctttt atcagcatct tttctctgta gctccagggg
     1621 aatcttctct agaacgttta tgccctcgct ttggctagaa acacattaac tggtttactc
     1681 atcgggaatc cagcatattt aagaggtaat cctgtgtttt ctgcaacatt gaggcattcg
     1741 tacagagctg cagtcaggca gagttgcggg gctagaagca gaagctgcca tcccattgca
     1801 ccaggacgga ggatgggact tcacttggca aagcagccct ggtcaaatct ggcagtccta
     1861 ttgccgggaa ttcctagccg aagattcggc cgtgtccttc cacccatcgt ataaaccgcc
     1921 cctctgagtc tctccagcga cccaaggcac aggagagtcc gaggagctgc taaacaaggg
     1981 ctgaggcaag caactcctta ggtcagcgct gactgaatgg aagccaggca gctgctccga
     2041 aagcctagcc ccacccttca tttcagtttt atacaaatgt ggaaacacac acatacacgc
     2101 acgcatacgc gcgcgcgcgc gcacacacac acacacacac acacacacac acacacacac
     2161 acacacacac acacacacac acacacacac acacggcccc agacttacaa acctattaag
     2221 ctctcacagt tggttactta gctaacactt gagattacat ttctccctag gaggagttag
     2281 cagtgatggg ttagttcagg cagctccacg tgcctattta cccctcgatc ctgaacacta
     2341 ctagaaccgt agggctggac cacacctgta ccgctgcgtc cacagcgtgc attctgagat
     2401 accactcagg gtgccaagtt cacactcatc ctcaggcaac agagaggatg gggctccccg
     2461 agtagtggga gttcttttgt ggcctgtgct ggggcaggga gccaacagca cccatttgta
     2521 catacaggtc attcgtgtgt cacatgttct aaacaggggt ctctgtgtgt atttgtgtgt
     2581 gtgttctacc tttctaccat atgtgatcag tttaatggta actttattta tttaaaaaaa
     2641 aagaaacaca gatagttact attgaactga ttaaggctgt gtatttgtac tcctaggaat
     2701 ggtcatatga agtagatgtg caatcatgta gacagcaggc caaggtgatc agtggctaag
     2761 gttggaaagg ggttggtttc tctcatatat gtatgtatgt gtgtgtagat gcgcatacat
     2821 aggtatatgc acacatagat tatgtgcttg gccactgcct tttaaaactt taaattaaat
     2881 aaaacgttgg ggatgattca attta
//
LOCUS       NM_001437933            9036 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 4, mRNA.
ACCESSION   NM_001437933 XM_039078942
VERSION     NM_001437933.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9036)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9036)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 9036)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 9036)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 9036)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 9036)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 9036)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 9036)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 9036)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 9036)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078942.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1594368.1,
                                           SRR26360190.1392179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000007.1  136253383-136253478 c
            97-196              JAXUCZ010000007.1  136228828-136228927 c
            197-379             JAXUCZ010000007.1  136227163-136227345 c
            380-566             JAXUCZ010000007.1  136218085-136218271 c
            567-667             JAXUCZ010000007.1  136213218-136213318 c
            668-9036            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..9036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..9036
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..96
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            97..196
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            197..379
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    219..221
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             243..818
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424862.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    297..446
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    297..446
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(297..308,357..359,363..365,396..398,408..428)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(297..308,357..359,363..365,396..398,408..428)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    588..761
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    588..761
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(615..617,621..635,657..659,684..686,744..746,
                     753..758)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(615..617,621..635,657..659,684..686,744..746,
                     753..758)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(627..629,741..749,753..758)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(627..629,741..749,753..758)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(711..713,723..728,732..737,744..749)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(711..713,723..728,732..737,744..749)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            380..566
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..667
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            668..9036
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgcgcaga aggcggcggt agcggtggct tgtggtgccg ctttgccaca gaggaaccgt
       61 gcaggcctta gtgtgagtga tcactttaga tcccggggaa ggccatagcc acaatgctta
      121 actgcatgct tccaacatgg ggctggtttt aacccagcgc tctgacctaa agtgctcagc
      181 tcccggaaat tccaaggaac ctggtggccg cactccttta ggtggaccaa cacataccca
      241 acatgggaaa gaagaccaag aggacagccg acagctcttc atcagaggat gaggaggagt
      301 atgtggtgga aaaggtgttg gacaggcgca tggttaaagg gcaagtggag tatctgctga
      361 agtggaaagg cttttctgag gagcacaaca cttgggaacc tgagaagaac ttggattgtc
      421 ctgaactaat ttctgagttt atgaaaaagt acaagaagat gaaggaggga gagaacaaca
      481 agcctaggga gaagtcagaa ggaaacaaga ggaaatccag tttttccaac agtgctgatg
      541 atattaaatc caaaaaaaag agagagcaaa gcaatgatat cgctcggggc tttgagagag
      601 gactggaacc agaaaagatc attggggcga cagattcctg tggagactta atgttcttaa
      661 tgaaatggaa agacacagat gaagctgacc tggtccttgc aaaagaagct aatgtgaaat
      721 gtccacaaat tgtgatagca ttttatgaag agagactgac gtggcatgcg tatccagagg
      781 atgcggaaaa caaagaaaaa gaaagcgcaa agagctaaag gaggaggcag tctctgtcat
      841 ttctctttgt atataatacc ttcaccttcc tgcctcctct cgcttctccc gtccctttcc
      901 atcctaaaca tatccataaa aatgatgtgc ttatcaatca ctgtgctcca cgggagagat
      961 gttggtattg gttcccttgt aatataactg atggtctgac tcctaagtgt agctctgtga
     1021 aagtcaggca ttacatcctt cacatgctgt gtggttccca tagtgttctc tttcatcctg
     1081 atcttttcct tctgttccct gtaactttta atcaccttag agtcgtgatc tttggggttg
     1141 gttgctttgg ggaattttat tataatgacg atgacttcag tttcttggtt gttaattaga
     1201 atatattgat gaccagctgg cctttgtttt gacatactgg catagaaagg atgttgtcca
     1261 gcttttagaa agctaatagc agcagcctac atgttgtgta ttttttaatc tcacttagct
     1321 ctgccaggag aatacagggt ccctggtgtg gtcttctggg ccactcctga ctattctcac
     1381 ctaccctccc ataacaactc agttctcttg agggcttgag actttacact gtttagccct
     1441 cacactcttt tggcttcgtt actttcaatc cctgattctg cttctgtaaa gtgtatcagt
     1501 ttgttattaa atgacaggat taactgtggg gtctgtaagc tgtagtgcag gacgataaca
     1561 ggacggggct ggatgcggtt gtctttggta tcacatggtg tgcatgtgtt ctttccttca
     1621 ccctcattcc tagactctat ttatgtaggt gtagggactg cctggtgctt gcttgtgcca
     1681 agcaccctgc caacttttat ggcctcccaa agcattcctg taccaaagag gaatcagcag
     1741 atccacacat tcccttccgt gccgttattt taagttggga attgttagaa aggaaccatt
     1801 agccacagtg tcatcagttt ctaaatcctc acagcagtga tagatactct ttaactttac
     1861 cactaagtcc ctagaggatt aatgttcctg ccctctccat cctcagactt ttagttgtag
     1921 cttattttaa aaactatttt catggaagac catcgcctca gaaaccaaca ggtcttgaca
     1981 ttagcttttt gacacaacct tctcccacaa caaactactc ctttttgatt tactcttact
     2041 ttgctattat ttctgctcct gttctgttct ttttgtcccc tgaaaatgtc catcttctct
     2101 tcattccttt cttcttatat agttgaggag actgagaatc aggactaaat gtaaggaaat
     2161 aacagggttt ggagctgagc actctttttt ttttttttcc cccccccccg gagctgggga
     2221 ccgaacccag ggccttgcgc ttcctaggta agcgctctac cactgagcta aatccccagc
     2281 cccaggagct gagcactctt gacccagctc aaaagctgag gaaaaggagt aaacgctgag
     2341 atagccttaa ttctagactt tatcaactac tgaggctgtt tttgttgttc ctttcggttt
     2401 ttaaagcata gctatctgag cagccaccca tttctagatc gttcatggta atgaggggaa
     2461 ggagtggagt gctctggtcc acagatgacc caagtgtgtg cacgtcctag acccattcag
     2521 tgtttgctag catcacttct ctgctcagct gccactgagc tctgtgttct tgaataaatt
     2581 atgtcaacaa ttatactgca cagttgacag gacagccagg aagaacctgt gaatggtact
     2641 gtggtagggg aagagcacct aacccttacc tctccgtagt tcattctctg aagatggtag
     2701 aggcaagctc aaaggctgga taagtgacca ttgtctgctt aacttgatga aatgcaggtg
     2761 gttagagagc agatgtgtcc ttcacgcaac ctagactagt aattagggca gatgaaggta
     2821 gcccagaagt ggcccagttc ctgaggatct tagtctctga ttagcagctg gagggaagga
     2881 cagcctgctg agcactcagc agcagtgggc tgtaaactgg cagtggaagg actgagtata
     2941 cagtttgagg atttaatgcc ttgtaatgca aaaaatgaag ggaaggagtg gcctgctggt
     3001 tttaatgctc tttacaatgt ttttccctct caaaagttca tggagtattg gttttctgtt
     3061 aattattacc aaaactctct tgtccgtgtc tccccccccc cccccccagc tggggaccga
     3121 acccagggcc ttgcgcttgc taggcaagtg ctctaccact gagctaaatc cccaacccct
     3181 tgttttcctc ttagtaagtt tcctggttat atatagaaat agggaaccgg gattccagta
     3241 ttctcttcag ctctcagtat gaagaagcca gacacccatt tgtgcctcca gcctgtgttg
     3301 tgccaagtag cttgattctg ctggagaatt gcagctgtgg acaaaagtgt ttcctagagt
     3361 tatcttctat cttcgctcta aagagttcat ggccaaaggt gaaagaaata ctcctaaaca
     3421 ctgactatat tctcctgtgt taaccctctc cagaactaat tttgtggtac tggaaattga
     3481 acctaggacc agcgtggaca gccgggcaac tgctgtgcca tttttgtctg ccccctttcc
     3541 tcccctgcca tacagttgat ggatcaccaa attcacctgt ttttgttgct ctaaggactt
     3601 taagtcactg ataccaagct aaccttggtt gtataaccaa gttgaattct tttttttttt
     3661 tttttaaact tatgtgacta tgttgttgct gtcttcagac acaccagaag aaggcatcgg
     3721 atcacattac agatggttgt gagccaccat gtggttgctg ggatttgaac tcaggacctc
     3781 tggaagagca gtcagtgctc ttaaccactg agccatcctc cagccctgct aagttgaatt
     3841 ctttttttct ttttttcttt ttctttttct tttttccgaa gctggggacc gaacccaggg
     3901 ccttgcgctt gctaggcaag cgctctacca ctgagctaaa tccccaaccc cctaagttga
     3961 attcttgatc tcctgcctct tcccagtctc taggattata ggtatgtgcc accatatctg
     4021 gctcttagct ccttctatat ggagttatct gtgctagcca ggtacagtgt aatacacctt
     4081 tatttccagt ctttaggagg cagaagtaga taaatcttaa tcggaggcct gcctggacta
     4141 tatagtgagt tctaggccag ccacacctac atagatcttg ttgtgaaagg aaaaatagga
     4201 aaagagtacc cagattggcc ttgaacttag gatctttatg tatcagttgt atgccactat
     4261 gcctggctca aaatgccttt ttttttcttt attaacttga gtatttctta tttacatttc
     4321 gatttttttt aagttatata tatatgtgat ttctgcctgc atgtatatgc accatatgca
     4381 tgcctggttc cctaggagac agaagagggt ctcatatcct cttagatagg agtgagccac
     4441 tatgtgggtg ttgagaatca gatctggaag agtagtcagt gctcttaact gctgagccat
     4501 ctcccaccct tcaaaacatc tttctaaagt tgaatttctt cccccccccc ttttctgttt
     4561 agtcctgact gtttcttgct ggcttcaccc tctagtgctc acgttttgct agctttgtgc
     4621 aaaaacaggt gaactgggtg atccatcctc aattttacac attgtgttgt tcacatttct
     4681 acaactttag catacatcaa tattgttttc attcaacaaa cagttttggc tcaggaactc
     4741 gctagagaac tttgatagtg gtgtgggatg agttgatcag tatagttttg gataatgaat
     4801 actgcacatg tatataaatt actggtctgg gacagcatca ggtatacaaa aaggtgagtc
     4861 tttagtgggc agttagttaa gtggttgagt gctggtgagg aatccatgaa gccctgggtt
     4921 tccacggggg ggggggtaag gtaaatctgc agtaggaggg gggggtaagg taaatctgca
     4981 gtaggagggg ggggtaaggt aaatctgcag taggagggtg ccattaactg cttcatctgt
     5041 gggaaagact gtggtcttgg atgaactgag ttaactggcc atgggcagca ttgcaggaaa
     5101 taaagctaga aaggctttcg tttcgttacc aagagtgcag atgaatgagc gtgagaactg
     5161 tcttgtttag actgccaagc attcatgact gtgttagtat tgcctgtgct ggtgtatatt
     5221 tcttctttgt gggcgtttta gcaagttgct cacactgttc aatttctcac ccttttggag
     5281 aaatcaacat tagtctggct ttaaagccca aaacatacca tctaatgaca agacttcctt
     5341 agaacaaagc ttaggaatga gctacctttg gatcacgtgg gtctcagtgc cagggagtaa
     5401 gcagctcctg tgtcacttat atcaaaacct tccacaggaa taatgtgctc tggctcctca
     5461 ttgtgcgtga cacccttctc agagaaggaa aggtctgttt ttcaggttct tattctgact
     5521 cctgagagcc caagacgaag atgtaattga ctgactttag aagtcagaat tcccagaaat
     5581 tcaactaact gctctagaag gttaaaatgt gaagtttctt gtttgttttt tgcttgtgct
     5641 gaatattttg aattttcatc tacctcgtct tatttttctt agttacttct gtcattacca
     5701 cttgagcatc aagcttgatt ttggtcattg tctaaaatgg ggtctctcct gttcagtgac
     5761 agtttattcc cttgtctttc ctcttggccc tcatttcacc taacatcatc tcttattgct
     5821 cctgtcagaa atatgtttta aagtcttgtt ttatgggaaa aagtggtcca ccaatgctgt
     5881 ttgtctctga ggtcagtgag agaaggagtt aaaacacagt ggtggaggaa gggcagagcc
     5941 tgcctgcact ggaggcaaaa gctgacaagg aaggagtcat taattaaaga caatttcaaa
     6001 gtcaactgat tgtgatcatt aatgtcacaa tagatcaaaa cctaattatc acagcctagg
     6061 taagagccat cagtattaat cggaaaatct aataggaaac tattagcaag aaattaggcc
     6121 aaattgaatg caatgaactt tttatcatct ttttttggta atgttcttgg tgttggcaac
     6181 tgtgacccta acagttggtc caagcccaga ttgctaattt taaagagcct tttttttttt
     6241 tttttttaag taacccaggc tgaccctagt gcttacagcc ctccagcttc agccttgagc
     6301 actgggatta tgaggggtac atgcatttgt gtttgtgtgg gtgggtagga gagaattgaa
     6361 ctcagggcct tgtacatttt agacaagtgc tctaccactg aactgtattc ctagctcaga
     6421 gtgttttgtt tgttagggaa gtttccagac agactgaacc taagctgaca ttgctgaaac
     6481 accagccttg aattttttta tcatatggat ctattcattc taatcagatc agcgggatat
     6541 aaacatatat attaaagtcg tagagtgtcc ctagtgaaca tcatatcatc tgttgagtgc
     6601 ttgtatatag agttctatac tggttgttgt gaaggctgtg ggaggaaggc agtgtcctgc
     6661 tttgaaattc tttgaaaact aaaaagatag tttccttgtg tgacagcatg atcaagatgc
     6721 aagtctgtgt ttttcagttt ccattagcat tagggtttga tcctaaacca gcttagcagt
     6781 gcccccaacc ccaatagttt taagataggc acaaaatgat ttcctactgg aattctaagg
     6841 tatggggaag acatctttgt ttctgttttc ctttctggta gtaggagaag catcagtatg
     6901 tccttaagat gtttgtaaag atgctacccc ctttaggtga gatgagtcag gctgtggaac
     6961 ggttgctgtc acaggaggag tgccaggcag tagtagaggg aattgtgctt aggagtctgc
     7021 actgtgccct gcagccctca gatgctcagt gctgacctta ggaggcccat gctgctttct
     7081 ggaccttggg aacctggatt acccagtaga agactgagaa tcaatgtctt ttgtttgttt
     7141 gtttattttt tgttctgttt ttgttttgtt ttgttttgtt ttccaagatg gggtctctgt
     7201 gtagccatgg atgtcctgga acttgctctg ttgaccagac tggcctcgaa ctcaaagatc
     7261 tgcctgcccc tgcctcccaa gtactgtgat caaacgtgtg cgccatcact gcctggctaa
     7321 cccttcactt cttagtgagt tttagtgttt aaaaaatgca acttaatttt caaagtggca
     7381 ctaaggtggt ttgtccagcc ttgggttact ccaggtgagc agcagccctc aattaacagt
     7441 gtgttgattg gactcatccg gctgcagtga aatgactgaa agtgagatgt tctagtgcat
     7501 agttctgtgc taacctccta cttggtctta atggctgacc ttgggcaagt ctttcctttc
     7561 aatgcctcag ttccccatct gtcaaatggg gtgataatac tgacctacct catggggtgt
     7621 tgtgaggcat tacagatcag agctgatcaa ccctttagga ttgcctgtgg aggatacctt
     7681 aagtcggact cttttagccc tcactgagct acttccaagt ttggaagtag ttagtgacct
     7741 tggcgagttt ctgtcccccc accctttacc cctcatcaaa gctgctagtt cagatgttaa
     7801 cagtgttttg tgaatgttgg agtcttgatc gtccagtcta acttgggaca atgtaaggga
     7861 aggcacttgt gggttctgtg tcttatatta caaagagact gttagaaatt caagagcctt
     7921 ggtttaggaa tcttgaggca ggaatgctac cgcatgtctt tctctgcagg agttaaggtc
     7981 ctattctcat ggacttataa ctacttctga ctgtcttcga aaggaagtga cacttggtat
     8041 tttggattta tattgttgct ttcattttcc agactgatcc taggacagtt agtctactga
     8101 acccttcatg cttctatgcc tctgccctct catagaagcc agatggttca agcaacatag
     8161 ctctcccttc ccccaccaaa aagctgtatt ggatttttgt ttttttgttt ctagaaatag
     8221 gtgtaacatt tcagaattga gcattggtcc tcaaggcttc ttccagttca ctgtgtgtgg
     8281 aatctgtcac ctcttttcag tgtccaccat ctgacccact gaggacatct tggacacttg
     8341 tttgcccact tgagggttca aaagccttac tctgtgtttc agtatagggc taaggcatcc
     8401 ccaagctctt cgtgataggt ttcctttccc ctacttgacc ttgtattggt accatgaaaa
     8461 agcacacagt cctagctccc tggaggtaca cactccagta ctgttaggtg gactctactc
     8521 ctaacaggga tcctagaggg ttctctggag gatgggaaag gagcagtctc atgtcctgcc
     8581 aagtagtagc cagcagttgc cttacccctg cctgctggcc atgttcccac ctcctcatgg
     8641 agagggcttt cagaggtcct cgaggctgga ttttctcagt ctctgctgtg ccattctgag
     8701 tgggaagcag accacacttt gtggccaggt gtctaagtgg aagtgaggtc ttgaattctc
     8761 ggtggacttt ttggtttgtg ggggagtttt ggttgtgttt cttggttcta tttcagccaa
     8821 actcgcctgc ttttgatttc tttaaaggat aagtggtcta tctatctata tacatgtatg
     8881 tttgcatttt aagtgtaaat gttttgaaaa aaaaaaacag acatgtcttt ctataactga
     8941 catccgattc agacatcatt ctctcccctt ccaccctctt ttccctcttt tcatactctt
     9001 gtattggttc taataaagga ttgcttttca aatatg
//
LOCUS       NM_133398               4928 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus metadherin (Mtdh), transcript variant 1, mRNA.
ACCESSION   NM_133398 XM_003750334 XM_006241522
VERSION     NM_133398.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Xiang,Y., Duan,Y., Peng,Z., Huang,H., Ding,W., Chen,E., Liu,Z.,
            Dou,C., Li,J., Ou,J., Wan,Q., Yang,B. and He,Z.
  TITLE     Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells
            Promote Vascular Calcification Through Astrocyte-Elevated Gene-1
  JOURNAL   Calcif Tissue Int 111 (1), 73-86 (2022)
   PUBMED   35195734
  REMARK    GeneRIF: Microparticles from Hyperphosphatemia-Stimulated
            Endothelial Cells Promote Vascular Calcification Through
            Astrocyte-Elevated Gene-1.
REFERENCE   2  (bases 1 to 4928)
  AUTHORS   Wang,Y., Zhang,W., Zhu,X., Wang,Y., Mao,X., Xu,X. and Wang,Y.
  TITLE     Upregulation of AEG-1 Involves in Schwann Cell Proliferation and
            Migration After Sciatic Nerve Crush
  JOURNAL   J Mol Neurosci 60 (2), 248-257 (2016)
   PUBMED   27351433
  REMARK    GeneRIF: AEG-1 was expressed mainly in Schwann cells of the distal
            sciatic nerve segment from injury.  Interference of AEG-1 inhibited
            both proliferation and migration of Schwann cells.
REFERENCE   3  (bases 1 to 4928)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4928)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4928)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   6  (bases 1 to 4928)
  AUTHORS   Emdad,L., Sarkar,D., Su,Z.Z., Randolph,A., Boukerche,H., Valerie,K.
            and Fisher,P.B.
  TITLE     Activation of the nuclear factor kappaB pathway by astrocyte
            elevated gene-1: implications for tumor progression and metastasis
  JOURNAL   Cancer Res 66 (3), 1509-1516 (2006)
   PUBMED   16452207
REFERENCE   7  (bases 1 to 4928)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 4928)
  AUTHORS   Kang,D.C., Su,Z.Z., Sarkar,D., Emdad,L., Volsky,D.J. and
            Fisher,P.B.
  TITLE     Cloning and characterization of HIV-1-inducible astrocyte elevated
            gene-1, AEG-1
  JOURNAL   Gene 353 (1), 8-15 (2005)
   PUBMED   15927426
REFERENCE   9  (bases 1 to 4928)
  AUTHORS   Britt,D.E., Yang,D.F., Yang,D.Q., Flanagan,D., Callanan,H.,
            Lim,Y.P., Lin,S.H. and Hixson,D.C.
  TITLE     Identification of a novel protein, LYRIC, localized to tight
            junctions of polarized epithelial cells
  JOURNAL   Exp Cell Res 300 (1), 134-148 (2004)
   PUBMED   15383321
REFERENCE   10 (bases 1 to 4928)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_133398.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.28375.1,
                                           SRR26360194.2156001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               JAXUCZ010000007.1  67192654-67193350
            698-799             JAXUCZ010000007.1  67208780-67208881
            800-884             JAXUCZ010000007.1  67220475-67220559
            885-1061            JAXUCZ010000007.1  67221235-67221411
            1062-1127           JAXUCZ010000007.1  67222718-67222783
            1128-1364           JAXUCZ010000007.1  67224204-67224440
            1365-1463           JAXUCZ010000007.1  67229897-67229995
            1464-1588           JAXUCZ010000007.1  67237466-67237590
            1589-1696           JAXUCZ010000007.1  67240852-67240959
            1697-1837           JAXUCZ010000007.1  67243630-67243770
            1838-1994           JAXUCZ010000007.1  67247056-67247212
            1995-4928           JAXUCZ010000007.1  67247886-67250819
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4928
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
     exon            1..697
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2065
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LYRIC; lysine-rich CEACAM1 co-isolated protein;
                     metastasis adhesion protein"
                     /codon_start=1
                     /product="protein LYRIC isoform 1"
                     /protein_id="NP_596889.1"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDP
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE
                     NITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKD
                     WGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSD
                     WNAPAEEWGNWVDEDRASLLKSQEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKK
                     QGEDNSITQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPVEVLIKNSQPI
                     KTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWE
                     SPKQIKKKKKARRET"
     misc_feature    320..532
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Activation of NF-kappa-B. /evidence=ECO:0000250"
     misc_feature    335..1585
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     misc_feature    335..1585
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     misc_feature    467..529
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     transmembrane region"
     misc_feature    533..823
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Interaction with BCCIP. /evidence=ECO:0000250"
     misc_feature    548..982
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    617..931
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Interaction with RELA. /evidence=ECO:0000250"
     misc_feature    743..745
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    854..856
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    962..964
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1067..1069
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1106..1108
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q80WJ7; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); acetylation site"
     misc_feature    1157..2062
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1208..1210
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1232..1234
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1247..1249
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1346..1348
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1421..1423
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1457..1645
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1W6.2);
                     Region: Lung-homing for mammary tumors.
                     /evidence=ECO:0000250"
     misc_feature    1559..1561
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1592..1594
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1685..1687
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1748..1750
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1796..1798
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    1802..1804
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86UE4; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     misc_feature    2018..2020
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1W6.2); phosphorylation site"
     exon            698..799
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            800..884
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1127
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1364
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1463
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1588
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1696
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1837
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1994
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..4928
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgcca ttgttccgcc gggggaggac agcgaggcct ggcgctggcg ccccgacgcc
       61 acttagcggc cgcctctgga gacactctgt ccccgccgcc ccgtgtcctc ctggcggcgg
      121 cggcgtgagg ccgactggag ggagtgggaa ccctcggccc tccccgtggc ggcggcggcc
      181 acctattccc cactctggag tgaggggcgg ccgcgatgcg cttggcctga ggtgtcgcgg
      241 ccctcgtcgc ttcccacgac tgttccagcg gcgtctgtgc tccccggcgt catcccgaga
      301 gtctctgacg ggagggaaga tggctgcacg aagctggcag gacgaactgg ctcagcaggc
      361 cgaggagggc tctgcccggc tgcgggagtt gctctctgtc ggcctaggtt ttctgcgcac
      421 ggagttgggc ctcgacctgg ggttggagcc gaagcggtac ccgagctggg tgatcctggt
      481 gggcaccggc gctctcgggt tgctgcttct cttcctccta ggttacggct gggccgctgc
      541 ttgcgccggc gcccgcaaaa agcgaaggag cccgccccgc aagcgggagg aggtgacccc
      601 gccgactccg gcccccgagg acccagccca actgaagaat ctcagaagcg aggagcaaaa
      661 gaaaaagaac cggaagaagc tgcctgaaaa gcccaaacca aatggacgga ctgttgaaat
      721 acctgaagat gaagttgtta gaactccccg aagtataact gccaagcagc caccagagac
      781 agacaagaaa aatgaaaagt caaagaaaaa taagaagaag tcaaagtcag atgctaaagc
      841 agtgcaaaac agttcacgcc atgatggaaa ggaagttgat gaaggagcct gggaaactaa
      901 aattagtcac agagagaaac gacaacagcg taaacgtgat aaagtgctga ctgattctgg
      961 ttcattggat tcaactatcc ctgggataga aaataccatc acagttacca ccgagcaact
     1021 tacaactgca tcatttcctg ttggttccaa gaagaataaa ggtgattctc atctaaatgt
     1081 tcaagttagc aactttaagt ctggaaaagg agattctaca cttcaggttt cttcagggtt
     1141 gaatgaaaat attactgtca atggaggagg ctggagtgaa aagtctgtaa aactctcctc
     1201 acaattgagt gcaggtgagg agaagtggaa ctctgtccca cctgcttctg caggcaagag
     1261 aaaaacagag cagtctgctt ggactcaaga ccctggtgat actaatgcaa atgggaaaga
     1321 ctggggaagg aattggagtg atcgctcaat attttctggc attggatcta ctgctgagcc
     1381 agtttctcag tctaccactt ctgattatca gtgggatggt agccgtaatc agccccatat
     1441 cgatgatgaa tggtctgggt taaatggttt gtcttctgct gatcctagct cagactggaa
     1501 tgcaccagca gaagagtggg ggaactgggt agatgaagat agagcttcac ttctgaagtc
     1561 ccaggagccg atttctaatg atcaaaagga ttcagatgat gataaggaaa aaggagaagg
     1621 agctcttcca actggaaaat ctaaaaagaa aaaaaagaaa aagaagaagc aaggtgaaga
     1681 taactctatc acccaggaca cagaagacct agaaaaggac actagagaag agcttccagt
     1741 gaatacctcg aaagcccgtc caaaacagga gaaagcttgt tccctgaaga ccatgagcac
     1801 tagtgatcca gttgaagtac tcatcaaaaa tagccagcct atcaagactc ttccacctgc
     1861 tatctctgcc gagccatctg ttactttatc aaagggtgac tctgacaaga gctcttccca
     1921 agtgccaccg atgttacaag acacagacaa acccaagtca aatgctaagc aaaacagtgt
     1981 gcctccctca cagaccaagt ctgaaactaa ttgggaatct ccaaaacaaa taaaaaagaa
     2041 gaaaaaggcc agacgggaaa cgtgaatttt tttcctaaat tggacatgtg tttacaaaca
     2101 ctgtcttgaa gattatgctg tttatgcaat aatttgtgaa catgtacaga gttttatata
     2161 aatttaaacc aatttttaaa acaaaactga acacaaccac cataaaatgg aatcaaagga
     2221 aagttaattt atgaaattaa gaggtcaaca atacatacta cagtgctgga agacactcgg
     2281 gagagacttt gcaattgaac gagaatgatc ataatttaag aatattatcc tggttttaca
     2341 acagttccct gtttacaaca gattgtgccc tgtttcatct gcagctgagg aataatggat
     2401 tctgattaga gagaaggctg cctagaagcc agtaggcaag tccttggatc ttatgcacga
     2461 ccttagacca tttgaatctg ttttatgctt aaatcaaagt gctttgatta aatgcatacc
     2521 tgccatatct ttacctattt gttgtagcaa tttgtattaa aagaatcaca agtgcaaata
     2581 aaaggtcatt tatcatttat ttaactaaac tgtcttggtt tagtttacag ttctttaaaa
     2641 gttctaaatt aaaacattga aaaatgcaat tgacagacac ctgtatggct tacaaagtta
     2701 tttttgatag tcttgcatta cttgaattat tcaaagtaac agtatatttt aaattaagaa
     2761 aggtaaatat attatttgtt tgatacatta agactgagac taacagtgct cttgtttatg
     2821 atttgaaaac ttttcaggca aaatccaact taatattttt cctttcccta gcaattttcc
     2881 agtgtcaact cttagttgct agtaattttt taccttaaaa ataaagtaat tcgcaacttt
     2941 tgagcatacg acggagaatg gaaaagtagt cagacagctt taattgacat tgtggagacc
     3001 tccggttatc aggaatacat ttttttactg ccttaacctc ctgtagtgcg tagaatatgc
     3061 atcaatttct tgaaggggat tcatgttttt ataagaattt tcatgtaact attgcaattg
     3121 tggtcaaaaa aaggaacatt ttctgcttga aactgtgttg atttaaatga cgtatgatct
     3181 gtcaccattt tcaggcactg tgtgattcct aggaaagtgg caggcctctc tgtaactgtt
     3241 aatagtgcat gctcggccat gtacactgta aatagccttt accaaacgtg tttgacaagg
     3301 accataatta acatcacttt agtgaattgt aattttaaaa aagccatgat ttattgatgt
     3361 gagcggcttg ttttcgtgtg gcgccaggaa tgaacctgtt taaaagctat aaccaatggt
     3421 actgatctat ccattaaata ctgtccttat atttgactgt agtttaatag tattgtcaac
     3481 taggaaagct acaagatgta aaatggtttt cgttctgttg aagactggcc ttattaatgg
     3541 acagctttcc tcagaagtga ttaacaactt tttttattgg gtgttaacat ctgtttcagg
     3601 aacatggcag tatgtttaca tgttgtcaga agttttgttt gattgaatgg gatttctaaa
     3661 ttaacttact tgtttaaata aattcagaaa tggatagcat tgtttttatt tgcttcacta
     3721 ttggggtaaa taatagctga tgtgccagga atggagcctt cagatggctg ctgtgagctt
     3781 catgttccct caggggatgc cacgctatgt ctcaaggaga agttgatagg gagtctgtaa
     3841 ttacagagtg tgccaaaagg tcagtgctca caagtttaat tgaactctct caactctacc
     3901 tcactgttcc ttttccttat aattctctgg gctagaacaa ataagaaact ttatttttca
     3961 cttcaatgtc tccggatgca atcacttata ggaggtggca cctacaccag gtagcaagaa
     4021 taccgtcttt ttgcagagga atatataatg gggggaagca gagtgacact gggtgggtca
     4081 gtgtggaggt ggcctctatg cctgccttct ctctggcttg cgagccaggc agtgtgtgtg
     4141 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg aaggaggcag
     4201 gtatatgagt gaaaattaat cattcactgc tctttgcctc tgtatagatc tttgtgtggc
     4261 agggcaggga tttcttgtca ctgatcagag gaactggttt ctgccatcaa ctcagaaaac
     4321 tctgagattt aggtaatggt gattagagag tggcaacaga agactgggta ttctctgctg
     4381 gccggaatga gggcccctga tgccacctgt ttccccaaaa ggctctctga aaagcctttc
     4441 tgttgtgggg cggggcatgg gcatgtcaga gttctccaac tgcattgtcc ctatcttata
     4501 ccctaaattg agaaacagtt gagagagtcc aaaaagaaag ttgaaataaa atatcattaa
     4561 tgtaatttac cttgtttaat ttgtgcatgc attttattgg ggaggggagg ttggaataat
     4621 ttatctaaaa ctaatggtat tatttcatag gctaatccag tttgtatttg agttaaagat
     4681 cccagagggt agtaattaat tacagagttt agtttttctt aattaaaagc agtcctctat
     4741 taatatagta tgaaatgtca aaatttagga tttaagttta aggtctaatg gctattttaa
     4801 agtttttctg taaactcatt gcacaaactg gaattggaat tgctttcaaa agacttggga
     4861 aatgaaaatg tgtcatgtaa gatgcactga gtgttgtaaa taaaatactg tttttgtttt
     4921 gtttaaaa
//
LOCUS       NM_182816               3115 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 2 (Amigo2),
            transcript variant 1, mRNA.
ACCESSION   NM_182816
VERSION     NM_182816.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Li,Z., Khan,M.M., Kuja-Panula,J., Wang,H., Chen,Y., Guo,D.,
            Chen,Z.J., Lahesmaa,R., Rauvala,H. and Tian,L.
  TITLE     AMIGO2 modulates T cell functions and its deficiency in mice
            ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   Brain Behav Immun 62, 110-123 (2017)
   PUBMED   28119027
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Kanda,Y., Osaki,M., Onuma,K., Sonoda,A., Kobayashi,M., Hamada,J.,
            Nicolson,G.L., Ochiya,T. and Okada,F.
  TITLE     Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to
            Liver Endothelial Cells Resulting in Liver Metastases
  JOURNAL   Sci Rep 7, 43567 (2017)
   PUBMED   28272394
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Park,H., Lee,S., Shrestha,P., Kim,J., Park,J.A., Ko,Y., Ban,Y.H.,
            Park,D.Y., Ha,S.J., Koh,G.Y., Hong,V.S., Mochizuki,N., Kim,Y.M.,
            Lee,W. and Kwon,Y.G.
  TITLE     AMIGO2, a novel membrane anchor of PDK1, controls cell survival and
            angiogenesis via Akt activation
  JOURNAL   J Cell Biol 211 (3), 619-637 (2015)
   PUBMED   26553931
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Rabenau,K.E., O'Toole,J.M., Bassi,R., Kotanides,H., Witte,L.,
            Ludwig,D.L. and Pereira,D.S.
  TITLE     DEGA/AMIGO-2, a leucine-rich repeat family member, differentially
            expressed in human gastric adenocarcinoma: effects on ploidy,
            chromosomal stability, cell adhesion/migration and tumorigenicity
  JOURNAL   Oncogene 23 (29), 5056-5067 (2004)
   PUBMED   15107827
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_182816.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB078879.1, AY237730.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3115              JAXUCZ010000007.1  130270639-130273753 c
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3115
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
     exon            1..3115
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    612..614
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="upstream in-frame stop codon"
     CDS             720..2282
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="amphoterin-induced protein 2; alivin 1; AMIGO-2;
                     amphoterin induced gene 2; transmembrane protein AMIGO2;
                     transmembrane protein AMIGO2-like"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_877968.3"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
                     /translation="MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTAC
                     ICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHN
                     NITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAF
                     GGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQ
                     LRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQD
                     SFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDK
                     DTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHA
                     HEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPT
                     RDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSETVIAEGILKSSRAKSDSDSVN
                     SVFSDTPFVAST"
     sig_peptide     720..830
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     mat_peptide     831..2279
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /product="Amphoterin-induced protein 2.
                     /evidence=ECO:0000255. /id=PRO_0000014512"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     misc_feature    867..932
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    867..932
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    888..890
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    921..986
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 1"
     misc_feature    <924..>1406
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <924..>1406
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    933..1001
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    933..1001
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    996..1061
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 2"
     misc_feature    1005..1070
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1005..1070
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1026..1028
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1068..1133
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 3"
     misc_feature    1071..1142
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1071..1142
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1140..1205
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 4"
     misc_feature    1143..1214
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1143..1214
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1212..1277
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 5"
     misc_feature    1215..1295
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1215..1295
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1293..1358
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 6"
     misc_feature    1374..1412
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1374..1412
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1557..1559
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1578..1580
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1608..1820
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1608..1820
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1632..1646
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1632..1646
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1674..1688
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1674..1688
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1728..1742
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1728..1742
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1749..1751
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1794..1811
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1794..1811
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1833..1835
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1857..1859
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1866..1868
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1878..1880
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1914..1976
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     transmembrane region"
     misc_feature    2028..2093
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2211..2279
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 gggccctgca gcctgcgagc gccaccggcg ggccggcttt ccccgccgcc caccccgctc
       61 ccggcgcggc cgagctccgg cggtacctgc agccgagcca gagagccggg gagccctcgc
      121 cgccgcctcg aaactcgcca aagttgagag gctgccgccc accgggagct ggagggaagg
      181 tgcgagcgcg cggggcgcga accggcagac ggacgcgcgg accttctgag cgcaccgccg
      241 tcggcggcct ctcccgagcc gctgcggctt ccccgcgctg tgagtggtcg gctagaccga
      301 cggctggcta agtatttccg ttcaattgtt tatgggatgc gattgtgtat tttttgtgtc
      361 ggcggaggga gttaaggcag aatgcaccct ttaaaaacaa aaacaacaac aacaaaaaaa
      421 atcctgagtt tctgatagtg agactgttgc attgagagga ggtacctgga aatcgtactg
      481 agttggagta atctaggaaa aatgcattta acaggttctt ttttttttaa agacccccca
      541 attggagatg gaacccatct caaaagttga ttggaacgaa agcaattacg gaataactct
      601 aaggggttaa ctagtggcag ttaacttgta cttctctccc gtttttaaat gttgttacca
      661 gattggtggg aggctgtgct ggtgagaagc gactggcaag aggctcagag gcgaccataa
      721 tgtcgttaag gttccacaca ctgcccaccc tgcctagagc tgtcaaaccg ggttgcagag
      781 agctgctgtg tctgttggtg atcgcagtga tggtgagccc cagctcctca ggactgtgcc
      841 ctacggcttg catctgtgcc actgacattg taagctgcac caacaaaaac ctgtctaagg
      901 tgcctgggaa ccttttccga ctgattaaaa gactggatct gagctataac agaatcggac
      961 tcctggatgc cgactggatt ccggtgtcgt tcgtcaagct gagcaccctg attgttcgcc
     1021 acaacaacat caccagcatt tccacgggca gcttctccac cactccaaat ttaaagtgtc
     1081 tcgacttatc gtccaatagg ctgaagtcgg tgaaaagtgc catgttccag gagctaaagg
     1141 ttctggaagt gctcctgctt tacaacaacc acatttccta tctggacccg gcagcgttcg
     1201 gagggctctc ccacttgcag aaactctacc tgagtgggaa cttcctcacg aagttcccta
     1261 tggatttgta tgtcgggagg ttcaagctgg ctgatctgac atttttagat gtttcgtaca
     1321 atcaaattgc ttccatacca atgcaccaca taaatttagt gccgggaaag cagctgaggg
     1381 gcatcttcct tcacgggaac cctttcgtct gtgactgttc cctgtactcc ttgctgacct
     1441 tctggtaccg taggcacttt aactctgtga cggatttcaa gcatgactac acctgtcgcc
     1501 tgtggttgga ctccaggcac tcccaccagc tgttgctgct ccaggatagc tttctgaact
     1561 gttctcacag cgtcatcaac ggctccttcc acgcacttgg ctttatccac gaggctcagg
     1621 ttggggaaag ggcgattgtc cactgtgacg gcaaaaccgg taacgggaac accgatttca
     1681 tctgggtggg tcccgacaac aggctgttgg agccggataa agacacgggg aactttcgag
     1741 tgttttacaa cggaagcctg gttatagaga accctggttt tgaggacgcc ggggtttact
     1801 cctgtatcgc catgaacagg cagcgcctgt tgaatgagac ggtggacatc atgataaacg
     1861 tgagcaattt caccataaac agatcccacc acgcccacga ggcatttaac acggctttca
     1921 ccaccctggc tgcctgcgtg gtcagtatcg tcctagtgct actgtacctg tacctgacac
     1981 cgtgtccctg caaatgtaga gacaagagac agaaaaacgc actgaaccaa agcaacgccc
     2041 attcgtccat tctcagtccc ggccccaccc gggatgcctc tgctgaggat cggaaggcag
     2101 gtaaaagagt ggtgtttttg gagcccctga aggatccagc ggtgggacag aatggaaaag
     2161 tcaagcttgt ccccagtgag accgttatag ccgagggcat cttaaagtcc tccagggcaa
     2221 aatctgactc agactcggtc aattccgtgt tctcagacac acccttcgtg gcatccactt
     2281 aaccgtgtgc ctgtgttcgt ctggtgtcgt gatttgacct ctccctaccc aactgcagtc
     2341 cacgaaatta gtagcaggag agaaactgtt ttgtcttttt gagagaaaac caaatggtgt
     2401 ctttatgatg gttgctagga agtgaggcag agcaccctgg ttgcttcctc gtgctgggta
     2461 aagatccagt tgattttgag agtcttaagt tcccagtaac agccatcagc atctttgagg
     2521 atttcaggct ggcctgaagg cggtaggacc agccattatc tcctggttat ctcggaggga
     2581 aaaaaaataa agctatgtgt tagcattctt taaaaataga accttttaac ttactagagc
     2641 caaagttgag ctgagctttt cttattttta agaaaaacac gagtggcttc tttcccctct
     2701 aaaagatgta gaaggaagaa tcggttattt atagatcata aagttagcat agaggttttt
     2761 cagccgaaac catcatttcg gaccaggata gacacactag taacatccac agaatcatgc
     2821 cacgtcccat ggagtgcaca ggggcctagc ttttagctgt cttctccgtc atctctgtgc
     2881 tgtatcctgg tacaaaagat gccccccaaa aagttaaagg tgtctttatg tgttgccaag
     2941 agtatgtgtc actgccaaac tgtctgagtc actccctaca ccctcaccgc agcagactca
     3001 ggtttgtcca cctgcgtgtg tatatgtaaa accttaagtt ctatgaatgg ccgtatagac
     3061 cccaatgtac tgtattccag acatttaaat cagcgtaaat acacgtgctc tgtga
//
LOCUS       NM_001437946            7501 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 5, mRNA.
ACCESSION   NM_001437946 XM_039093039
VERSION     NM_001437946.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7501)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7501)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7501)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039093039.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.37512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000015.1  105199266-105199522 c
            258-374             JAXUCZ010000015.1  105182942-105183058 c
            375-464             JAXUCZ010000015.1  105168842-105168931 c
            465-547             JAXUCZ010000015.1  105162379-105162461 c
            548-617             JAXUCZ010000015.1  105160417-105160486 c
            618-713             JAXUCZ010000015.1  105158803-105158898 c
            714-848             JAXUCZ010000015.1  105157736-105157870 c
            849-1023            JAXUCZ010000015.1  105151440-105151614 c
            1024-1091           JAXUCZ010000015.1  105149491-105149558 c
            1092-1166           JAXUCZ010000015.1  105137132-105137206 c
            1167-1307           JAXUCZ010000015.1  105135597-105135737 c
            1308-1505           JAXUCZ010000015.1  105134347-105134544 c
            1506-1628           JAXUCZ010000015.1  105133869-105133991 c
            1629-1711           JAXUCZ010000015.1  105129765-105129847 c
            1712-1834           JAXUCZ010000015.1  105129126-105129248 c
            1835-1914           JAXUCZ010000015.1  105124162-105124241 c
            1915-2102           JAXUCZ010000015.1  105123885-105124072 c
            2103-2168           JAXUCZ010000015.1  105123662-105123727 c
            2169-2261           JAXUCZ010000015.1  105122343-105122435 c
            2262-2385           JAXUCZ010000015.1  105120141-105120264 c
            2386-2507           JAXUCZ010000015.1  105119666-105119787 c
            2508-2594           JAXUCZ010000015.1  105118736-105118822 c
            2595-2684           JAXUCZ010000015.1  105117931-105118020 c
            2685-2800           JAXUCZ010000015.1  105115724-105115839 c
            2801-2870           JAXUCZ010000015.1  105113993-105114062 c
            2871-2996           JAXUCZ010000015.1  105113031-105113156 c
            2997-3068           JAXUCZ010000015.1  105111200-105111271 c
            3069-3215           JAXUCZ010000015.1  105101578-105101724 c
            3216-3299           JAXUCZ010000015.1  105101310-105101393 c
            3300-3411           JAXUCZ010000015.1  105100567-105100678 c
            3412-3590           JAXUCZ010000015.1  105098660-105098838 c
            3591-3704           JAXUCZ010000015.1  105098365-105098478 c
            3705-3822           JAXUCZ010000015.1  105096851-105096968 c
            3823-3956           JAXUCZ010000015.1  105091621-105091754 c
            3957-4071           JAXUCZ010000015.1  105089536-105089650 c
            4072-4138           JAXUCZ010000015.1  105087183-105087249 c
            4139-4186           JAXUCZ010000015.1  105085955-105086002 c
            4187-4230           JAXUCZ010000015.1  105082924-105082967 c
            4231-4346           JAXUCZ010000015.1  105076918-105077033 c
            4347-4484           JAXUCZ010000015.1  105074536-105074673 c
            4485-4667           JAXUCZ010000015.1  105074236-105074418 c
            4668-4781           JAXUCZ010000015.1  105072671-105072784 c
            4782-4997           JAXUCZ010000015.1  105072316-105072531 c
            4998-5055           JAXUCZ010000015.1  105069893-105069950 c
            5056-5162           JAXUCZ010000015.1  105067917-105068023 c
            5163-5285           JAXUCZ010000015.1  105053003-105053125 c
            5286-5399           JAXUCZ010000015.1  105051698-105051811 c
            5400-5546           JAXUCZ010000015.1  105050156-105050302 c
            5547-5757           JAXUCZ010000015.1  105046980-105047190 c
            5758-5948           JAXUCZ010000015.1  105035414-105035604 c
            5949-6049           JAXUCZ010000015.1  105031777-105031877 c
            6050-6188           JAXUCZ010000015.1  105031234-105031372 c
            6189-7501           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7501
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..257
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="upstream in-frame stop codon"
     CDS             138..6311
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 5 is encoded by transcript variant 5;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 5"
                     /protein_id="NP_001424875.1"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MQADKYRTSGRNDKKELVIESPLQYKDAAQADSEAENSALAKPK
                     LIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEEEA
                     QSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADKDE
                     DAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEK
                     ISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKI
                     LQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVK
                     LFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVE
                     PFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQAA
                     MQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQ
                     ACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADFRK
                     PEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCI
                     PKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGR
                     PGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGST
                     KKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEVKW
                     VEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEG
                     HVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAY
                     KAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE
                     NNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFT
                     FMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQ
                     RYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDD
                     RYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGNPL
                     MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPD
                     RNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNK
                     ASTAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVAHQSL
                     LEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMAL
                     KNVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRN
                     NFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSF
                     SSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMAR
                     IHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGM
                     QDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLH
                     RAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLK
                     LYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCHN
                     IRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEV
                     AIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRY
                     PDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMRE
                     QICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    4932..6176
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    4932..6176
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5244..5246,5274..5276,5280..5285,5289..5294,
                     5301..5306,5310..5315,5322..5327)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5244..5246,5274..5276,5280..5285,5289..5294,
                     5301..5306,5310..5315,5322..5327)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5346..5357,5361..5363,5448..5453,5457..5468,
                     5472..5477,5532..5540,5589..5591,5595..5597,5682..5684,
                     5688..5690,5709..5714,5730..5732,5847..5852,5859..5861,
                     5901..5903,5907..5909,5919..5921,5928..5936,5943..5954,
                     5958..5963,5970..5972,6054..6056,6108..6113,6117..6122,
                     6129..6131)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5346..5357,5361..5363,5448..5453,5457..5468,
                     5472..5477,5532..5540,5589..5591,5595..5597,5682..5684,
                     5688..5690,5709..5714,5730..5732,5847..5852,5859..5861,
                     5901..5903,5907..5909,5919..5921,5928..5936,5943..5954,
                     5958..5963,5970..5972,6054..6056,6108..6113,6117..6122,
                     6129..6131)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    5943..5960
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    5943..5960
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            258..374
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            375..464
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..547
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            618..713
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1091
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1505
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1628
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1834
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1914
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2102
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2385
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2507
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2800
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2870
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3215
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3299
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3411
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3590
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3704
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3822
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3956
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4071
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4138
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4186
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4230
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4346
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4484
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4667
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4668..4781
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4782..4997
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5055
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5162
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5285
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5399
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5546
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5757
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5758..5948
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6049
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6050..6188
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6189..7501
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccaccc ctgaggctcc gcacttccag ccttgtgcct gggaaacagg cttccttgcc
       61 tttctctggc cagtggtgca gcaggggact ctcagctgtc cctgctgcag gctttctgac
      121 agtggtctgg gtggagaatg caggctgata agtacaggac tagcggtaga aatgacaaga
      181 aggagctggt catcgagtct cccctgcagt acaaggatgc agctcaggca gactcggagg
      241 cagagaactc ggcattggca aagccaaagc tgattgagcc acttgactac gaaaatgtca
      301 tcgtgcagaa gaagacccag atcctgaatg actgtctgcg ggagatgctc ctcttccctt
      361 acgatgactt ccagacggcc atcctgaggc ggcaggggcg ctacgtacgt tccacggtcc
      421 ctgcaaatgc agaggaggaa gcacagagcc tgtttgtcac cgagtgcatc aaaacctaca
      481 actctgactg gcaccttgtg acctatcact atgaagatta ctcaggagag ttccgacagc
      541 ttccaaacaa agtggccaag ttggataaac ttccagttca cgtctatgaa gtcgatgagg
      601 aggctgacaa agatgaggac gctgcttccc ttgggtctca gaagggtgga atcacaaagc
      661 acggctggct gtacaaaggc aacatgaaca gtgccatcag cgtgaccatg aggtcattca
      721 agaggcggtt tttccacctg attcagcttg gcgatggatc ctataatcta aacttttata
      781 aagatgagaa gatctccaag gagccgaaag ggtccatatt cctggattcc tgcatgggcg
      841 tgatccagaa caacagagtc aggcgcttcg cctttgagct caagatgcag gacaaaagca
      901 gttaccttct ggctgcggac agtgaggcag agatggagga gtgggtcaca gtcctcaaca
      961 agatcctcca gctcaacttt gaggctgcaa tgcaagagaa gcgaaatggg gaccctcatg
     1021 aagatgatga acaaagcaaa ctggaaggtt ccggttccgg tttggacagc tacctgcctg
     1081 aacttgccaa gagcaccaga gaagcagaaa tcaaactgaa aagcgagagc agagtgaagc
     1141 tcttttactt ggacccagat acccagaaac tcgacttctc atctgctgaa ccagaagtga
     1201 agccatttga agaaaagttt gggaagagga ttctcgtcaa gtgcaatgat ttgtccttca
     1261 acctgcagtg ctgtgtcgca gagaacgagg aaggacccac gacaaatgtg gagcctttct
     1321 ttgtcaccct gtccctgttc gacataaaat acaaccggaa gatttctgct gacttccacg
     1381 tggacctgaa ccacttctca gtgcggcaga tgctggcccc tgcatcccca gtgctgatga
     1441 acggtggtca gagtccacct gccttccagg atgcccttca ggcggccatg cagtatccga
     1501 agcagggaat attttcagtc acgtgtcctc acccagacat atttcttgtg gccagaattg
     1561 aaaaggtcct ccaaggaagc atcacgcact gtgctgagcc ttacatgaaa agctcagact
     1621 cttctaaggt cgctcagaag gtgctgaaga atgccaagca ggcatgtcaa agactaggac
     1681 agtaccgaat gccgtttgct tgggcagcaa ggacgttgtt taaagacaca tctggaaacc
     1741 tggataaaaa tgccaggttt tctgccatct accggcaaga cagcaataag ctctcaaatg
     1801 aggacatgct caagctgctc gcagacttcc ggaaacctga gaagatggcc aaactcccag
     1861 tgattttagg caatctagac attacaatcg acaacgtttc ctgcgacttc cctaattacc
     1921 tgaattcatc atacattccc atgaggcagt ttgaaacctg cagtaagtct ccgatcacct
     1981 tcgaagtaga ggagtttgtg ccctgcatac ccaagcacac ccagccttat acagtctaca
     2041 gcaatcacct ttatgtttac cccaagtact tgagatacga cagccagaag tcttttgcca
     2101 aggccagaaa cattgcaatc tgcattgagt tcaaggattc cgatgaagaa gactcgcaac
     2161 ccttgaagtg catttacggc agacctggtg gcccagtgtt cacaaggagt gccctcgctg
     2221 cagtcctaca ccatcaacaa agcccagaat tctacgatga gatcaagata gagctgcccg
     2281 cccagctgca cgagaagcac catttactgt tcaccttctt ccacgtcagc tgcgacaact
     2341 cgaccaaagg gagcacgaag aagaaggacg ctgtggagac acaggttggc ttctcctggc
     2401 ttcctctcct gaaagacggc agagtgttga cgaatgaaca gcatatccct gtctccgcca
     2461 acctgccgtc tggctacctt ggctaccagg agctcagcat gggcaggcat tatggtccag
     2521 aagttaagtg ggtggaagga ggcaagccat tgttgaaaat ctccactcat ctggtttcca
     2581 ccgtgtacac tcaggatcag cacttacaca attttttcca atactgtcag aaaacggaat
     2641 ctggagccca agcctcaggg agtgaactag tgaaatacct taagagtctg catgcaatgg
     2701 aaggtcacgt gatgatcgcc ttcctgccga ccattttaaa ccagctattc cgagtcctca
     2761 ccagagccac ccaggaggag gttgcagtta atgtgactcg ggtcattatt catgtggttg
     2821 cccagtgcca tgaggaagga ttggagagcc acttgaggtc atatgttaag tttgcctaca
     2881 aggctgagcc gtatatagca tccgagtata agacagtgca cgaggaactg acgaaatcca
     2941 tgaccaccat tctcaagcct tctgctgatt tccttaccag caacaaactt ctgaagtact
     3001 cttggttttt ctttgatgtg ctgataaagt ccatggctca gcatttgatt gaaaataaca
     3061 aagtgaagtt acttcgaaac cagagatttc cggcctccta ccatcacgcc gtggaaaccg
     3121 tggtgaacat gctgatgccg cacatcacac agaagtttcg agataaccca gaagcatcta
     3181 agaatgccaa tcacagcctg gccgtgttca tcaagagatg cttcaccttc atggacagag
     3241 gcttcgtctt caaacagatc aacaactaca tcagttgctt tgctcctgga gaccccaaga
     3301 ctctctttga gtacaagttt gagtttctcc gtgtggtgtg caaccatgaa cactatattc
     3361 ctttgaactt gccgatgcca tttgggaaag gaagaattca gagataccaa gatctccagc
     3421 ttgactactc tttaacggac gaattctgca gaaaccactt cttggtggga ctgttactaa
     3481 gggaggtggg tactgcactc caggagttcc gggaggtccg tgtcatcgct gtcagtgtgc
     3541 tcaagaacct tctgatcaag cattcttttg atgacagata cacttcaagg agtcaccagg
     3601 caaggatagc caccctctac ctgcctctgt ttggtctgct tattgaaaac gtccagcgga
     3661 tcaacgtgag ggatgtgtcg cccttccctg tgaacccggg cagtatctcg aaggacgaag
     3721 ccctggccgt gcctaccggg aatccactca tgactccgca gaagggaaac acacttgacc
     3781 acagcctgca caaagacctc ttgggtgcca tctccggcat tgcttctccg tatacagctt
     3841 caacccccaa catcaacagt gtgagaaatg ccgactcaag gggctctctc atcagcacgg
     3901 actcggggaa cagccttcca gacaggaacc ccgagaagag caactccctg gacaagcagc
     3961 agcagagcgg catgctggga aattctgtgg tccgctgtga caaactggac cagtctgaga
     4021 tcaagagcct gctgatgtgc ttcctctacg tgttgaagag catgtctgac gatgccctgt
     4081 ttacgtactg gaacaaggct tccactgctg aactgatgga tttctttacc atatctgaag
     4141 tgtgcctgca ccagttccag tacatgggga agcgctacat agccagtgtg agaaagatat
     4201 caagtgtgct tgggatttct gtagacaatg gctacggcca ctcggaggca gatgtcgctc
     4261 accagtcgct tctcgaagca aacatcgcca ctgaggtctg cctcacagct ctggacaccc
     4321 tctcgctgtt cacactggct tttaagaacc agctcctagc tgaccatgga cataatccac
     4381 tcatgaagaa agtttttgat gtctacctgt gtttcctcca aaagcatcag tcagaaatgg
     4441 ctttaaaaaa tgtcttcact gccttaaggt cattaattta taagttcccc tcaacgttct
     4501 acgaggggcg ggcagacatg tgcgcatctc tgtgctatga ggttctcaag tgctgtaact
     4561 ccaagctcag ctccatccgc accgaggcct cccagctgct ctacttcctg atgaggaaca
     4621 acttcgacta cacagggaag aagtcttttg tccggacaca cttacaggtc atcatctctg
     4681 tcagccagct gatcgcagac gtggttggca ttggaggaac cagattccag cagtccttgt
     4741 ctatcatcaa caactgtgcc aatagcgacc ggctcattaa gcacaccagc ttctcctctg
     4801 atgtgaagga tttgaccaag aggatccgca cagtcctgat ggccacagcc cagatgaagg
     4861 aacatgagaa cgacccagag atgctggtgg acctgcagta cagcctggcc aagtcctacg
     4921 ccagcacccc tgagctcagg aagacatggc tggacagcat ggcaaggatc catgttaaaa
     4981 atggggatct ctcagaggca gcaatgtgct atgtccacgt gacagctttg gtagcggaat
     5041 atctcacacg gaaaggcatg ttcagacagg ggtgcacagc cttcagggtc atcacaccaa
     5101 acattgatga agaggcttcc atgatggaag atgtcggcat gcaggatgtc catttcaatg
     5161 aggatgtgct gatggagctg ctggagcagt gcgcagatgg actttggaag gcagagcgct
     5221 acgagctgat tgctgacatc tataaactca tcatccccat ctatgaaaag cggagggact
     5281 ttgagagact agcccacctg tatgacacgc tgcaccgcgc atacagcaaa gtgacagagg
     5341 tcatgcactc gggccgcagg ctcctgggga cctacttccg ggtggccttc ttcggacagg
     5401 gattcttcga agatgaagac gggaaggaat acatctacaa agagcccaaa ctcacgcctc
     5461 tgtcagagat ttctcagaga ctccttaaac tttactcgga taaattcggt tctgaaaatg
     5521 tcaaaatgat acaggattct ggcaaggtca acccgaagga tctggattcc aagtttgctt
     5581 acatccaggt gacccatgtg accccgttct ttgatgaaaa ggagttacag gagaggaaaa
     5641 cagagtttga acgatgtcac aacatccggc gcttcatgtt cgagatgccc ttcacccaga
     5701 ctgggaagag gcagggtggc gtggaggagc agtgtaagcg acggaccatc ctgacagcaa
     5761 tacactgctt cccctatgta aagaagcgga tccctgtcat gtaccagcac cacactgacc
     5821 tgaaccccat tgaggtggcc atcgatgaaa tgagcaagaa agtggccgag ctccgccagc
     5881 tgtgttcctc agctgaagtg gacatgatca aactgcagct caaactgcag ggcagtgtga
     5941 gcgtccaggt caatgctggc ccgctagcat acgcccgagc cttcctcgat gacaccaaca
     6001 caaagagata ccctgacaat aaggtgaagc tgctgaagga agttttcagg caattcgtgg
     6061 aagcttgtgg ccaagccttg gcagtgaacg aacgtctgat taaagaggac cagctggagt
     6121 accaggaaga gatgaaagcc aactacaggg agatggccaa ggagctctcc gacatcatgc
     6181 gtgagcaaat ttgccccctg gaggagaaga caagcgtgct accaaattcc ctgcacatct
     6241 tcaacgccat cagtgggaca ccaacaagca cagtggttca agggttgacc agttcatcct
     6301 cagttgtgtg actttacctc atgaaccaca cgtggggaca tgctttgtca tgtgcaaact
     6361 caggacgact ttcagagcta atcactggtt ttgccaagca caggaagaag ccatggggaa
     6421 tgggagagag aaagagcctg gactgtgata tttaatagca gattttatag gagttggggg
     6481 aaggtgcaca tattttttta aatatcactg gcaatgttta gttttcctca tgtcttaaca
     6541 ggtgtatgtg gatactcttg ggctgcagtt caattttatt cttcttacag tatagtatta
     6601 aaataaatgg tctaaaggaa aagagggaaa gtatgctggg acacctgtag caggtgtgct
     6661 gggacacctg taccagctgt gctgggacac ctgtaccagc tgtgctggga cacctgtagc
     6721 agatgcagca gcactgaacc tgggaatggg gactaagctg gaaaaatctt gaaaatattt
     6781 ttctccctgt ggcacattca ggttgagtac aagaactatt tttgtgtcta gttttgaaga
     6841 ctgaagggaa ttgactattg agatttttta ctagtgaatg cggagactta gagcctttat
     6901 atccatgcct tgtgttgaca acatgagcac ttccgaagct gagtgtgatg tgagcctaag
     6961 cctagtcagc agcatagaac caaaggcctg cactagcgaa cacacctatg ctaaaaccta
     7021 aaaccccatg tacatatgtt ctgttaatac ggcctcctcg ctgagtccac gtacttacta
     7081 catttctaca cttttaatac atcagtgtcc gtgttaagtt tattattcgt gacccatttg
     7141 tgctgttctc ggtatatgca aatacattgg acttcactgt ttattcttgt acataagaag
     7201 tgcaatatgg agatgtatac agtctttgct atgttaggtt tataaactgt ttttaaaaag
     7261 aaattcatcc ttttgccaaa atggtggagt atgtgattgg taaaccctaa accctgtggt
     7321 gagtggaggg ataatttaaa gttttcacca tgttatattt tcttttaaga ctttaattta
     7381 gtaattttat atttgggaaa ataaaggttt ttaatttaac tggaatcact gccctgctgt
     7441 aattacatat cgtgtacccc aactgtatta aaaataacac tgctgatttt ctggtaataa
     7501 a
//
LOCUS       NM_001437934            9112 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 5, mRNA.
ACCESSION   NM_001437934 XM_039078946
VERSION     NM_001437934.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9112)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9112)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 9112)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 9112)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 9112)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 9112)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 9112)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 9112)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 9112)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 9112)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_039078946.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2817719.1,
                                           SRR26360181.2600024.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000007.1  136252983-136253094 c
            113-272             JAXUCZ010000007.1  136252327-136252486 c
            273-455             JAXUCZ010000007.1  136227163-136227345 c
            456-642             JAXUCZ010000007.1  136218085-136218271 c
            643-743             JAXUCZ010000007.1  136213218-136213318 c
            744-9112            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..9112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..9112
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..112
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            113..272
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            273..455
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    295..297
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             319..894
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424863.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    373..522
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    373..522
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(373..384,433..435,439..441,472..474,484..504)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(373..384,433..435,439..441,472..474,484..504)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    664..837
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    664..837
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(691..693,697..711,733..735,760..762,820..822,
                     829..834)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(691..693,697..711,733..735,760..762,820..822,
                     829..834)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(703..705,817..825,829..834)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(703..705,817..825,829..834)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(787..789,799..804,808..813,820..825)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(787..789,799..804,808..813,820..825)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            456..642
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            643..743
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..9112
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtttttct tgcctgagtt gcgtctctcc gagccaatga accccaagcg cgccataggc
       61 cggccttccc caagaggcag aggctggact ccagtgggga gcgcgggagt cgtcattatg
      121 ttcttgtgac cactattcat gtttccaatt cttcgagtgt ctcctccgaa gaacattttt
      181 ctcccctaac attcaagata tcctaagctc ctatttctgc tgttcatttg aggatgtctg
      241 attctgggtg aaaaagctga ttcatttgaa aggaacctgg tggccgcact cctttaggtg
      301 gaccaacaca tacccaacat gggaaagaag accaagagga cagccgacag ctcttcatca
      361 gaggatgagg aggagtatgt ggtggaaaag gtgttggaca ggcgcatggt taaagggcaa
      421 gtggagtatc tgctgaagtg gaaaggcttt tctgaggagc acaacacttg ggaacctgag
      481 aagaacttgg attgtcctga actaatttct gagtttatga aaaagtacaa gaagatgaag
      541 gagggagaga acaacaagcc tagggagaag tcagaaggaa acaagaggaa atccagtttt
      601 tccaacagtg ctgatgatat taaatccaaa aaaaagagag agcaaagcaa tgatatcgct
      661 cggggctttg agagaggact ggaaccagaa aagatcattg gggcgacaga ttcctgtgga
      721 gacttaatgt tcttaatgaa atggaaagac acagatgaag ctgacctggt ccttgcaaaa
      781 gaagctaatg tgaaatgtcc acaaattgtg atagcatttt atgaagagag actgacgtgg
      841 catgcgtatc cagaggatgc ggaaaacaaa gaaaaagaaa gcgcaaagag ctaaaggagg
      901 aggcagtctc tgtcatttct ctttgtatat aataccttca ccttcctgcc tcctctcgct
      961 tctcccgtcc ctttccatcc taaacatatc cataaaaatg atgtgcttat caatcactgt
     1021 gctccacggg agagatgttg gtattggttc ccttgtaata taactgatgg tctgactcct
     1081 aagtgtagct ctgtgaaagt caggcattac atccttcaca tgctgtgtgg ttcccatagt
     1141 gttctctttc atcctgatct tttccttctg ttccctgtaa cttttaatca ccttagagtc
     1201 gtgatctttg gggttggttg ctttggggaa ttttattata atgacgatga cttcagtttc
     1261 ttggttgtta attagaatat attgatgacc agctggcctt tgttttgaca tactggcata
     1321 gaaaggatgt tgtccagctt ttagaaagct aatagcagca gcctacatgt tgtgtatttt
     1381 ttaatctcac ttagctctgc caggagaata cagggtccct ggtgtggtct tctgggccac
     1441 tcctgactat tctcacctac cctcccataa caactcagtt ctcttgaggg cttgagactt
     1501 tacactgttt agccctcaca ctcttttggc ttcgttactt tcaatccctg attctgcttc
     1561 tgtaaagtgt atcagtttgt tattaaatga caggattaac tgtggggtct gtaagctgta
     1621 gtgcaggacg ataacaggac ggggctggat gcggttgtct ttggtatcac atggtgtgca
     1681 tgtgttcttt ccttcaccct cattcctaga ctctatttat gtaggtgtag ggactgcctg
     1741 gtgcttgctt gtgccaagca ccctgccaac ttttatggcc tcccaaagca ttcctgtacc
     1801 aaagaggaat cagcagatcc acacattccc ttccgtgccg ttattttaag ttgggaattg
     1861 ttagaaagga accattagcc acagtgtcat cagtttctaa atcctcacag cagtgataga
     1921 tactctttaa ctttaccact aagtccctag aggattaatg ttcctgccct ctccatcctc
     1981 agacttttag ttgtagctta ttttaaaaac tattttcatg gaagaccatc gcctcagaaa
     2041 ccaacaggtc ttgacattag ctttttgaca caaccttctc ccacaacaaa ctactccttt
     2101 ttgatttact cttactttgc tattatttct gctcctgttc tgttcttttt gtcccctgaa
     2161 aatgtccatc ttctcttcat tcctttcttc ttatatagtt gaggagactg agaatcagga
     2221 ctaaatgtaa ggaaataaca gggtttggag ctgagcactc tttttttttt ttttcccccc
     2281 cccccggagc tggggaccga acccagggcc ttgcgcttcc taggtaagcg ctctaccact
     2341 gagctaaatc cccagcccca ggagctgagc actcttgacc cagctcaaaa gctgaggaaa
     2401 aggagtaaac gctgagatag ccttaattct agactttatc aactactgag gctgtttttg
     2461 ttgttccttt cggtttttaa agcatagcta tctgagcagc cacccatttc tagatcgttc
     2521 atggtaatga ggggaaggag tggagtgctc tggtccacag atgacccaag tgtgtgcacg
     2581 tcctagaccc attcagtgtt tgctagcatc acttctctgc tcagctgcca ctgagctctg
     2641 tgttcttgaa taaattatgt caacaattat actgcacagt tgacaggaca gccaggaaga
     2701 acctgtgaat ggtactgtgg taggggaaga gcacctaacc cttacctctc cgtagttcat
     2761 tctctgaaga tggtagaggc aagctcaaag gctggataag tgaccattgt ctgcttaact
     2821 tgatgaaatg caggtggtta gagagcagat gtgtccttca cgcaacctag actagtaatt
     2881 agggcagatg aaggtagccc agaagtggcc cagttcctga ggatcttagt ctctgattag
     2941 cagctggagg gaaggacagc ctgctgagca ctcagcagca gtgggctgta aactggcagt
     3001 ggaaggactg agtatacagt ttgaggattt aatgccttgt aatgcaaaaa atgaagggaa
     3061 ggagtggcct gctggtttta atgctcttta caatgttttt ccctctcaaa agttcatgga
     3121 gtattggttt tctgttaatt attaccaaaa ctctcttgtc cgtgtctccc cccccccccc
     3181 cccagctggg gaccgaaccc agggccttgc gcttgctagg caagtgctct accactgagc
     3241 taaatcccca accccttgtt ttcctcttag taagtttcct ggttatatat agaaataggg
     3301 aaccgggatt ccagtattct cttcagctct cagtatgaag aagccagaca cccatttgtg
     3361 cctccagcct gtgttgtgcc aagtagcttg attctgctgg agaattgcag ctgtggacaa
     3421 aagtgtttcc tagagttatc ttctatcttc gctctaaaga gttcatggcc aaaggtgaaa
     3481 gaaatactcc taaacactga ctatattctc ctgtgttaac cctctccaga actaattttg
     3541 tggtactgga aattgaacct aggaccagcg tggacagccg ggcaactgct gtgccatttt
     3601 tgtctgcccc ctttcctccc ctgccataca gttgatggat caccaaattc acctgttttt
     3661 gttgctctaa ggactttaag tcactgatac caagctaacc ttggttgtat aaccaagttg
     3721 aattcttttt tttttttttt taaacttatg tgactatgtt gttgctgtct tcagacacac
     3781 cagaagaagg catcggatca cattacagat ggttgtgagc caccatgtgg ttgctgggat
     3841 ttgaactcag gacctctgga agagcagtca gtgctcttaa ccactgagcc atcctccagc
     3901 cctgctaagt tgaattcttt ttttcttttt ttctttttct ttttcttttt tccgaagctg
     3961 gggaccgaac ccagggcctt gcgcttgcta ggcaagcgct ctaccactga gctaaatccc
     4021 caacccccta agttgaattc ttgatctcct gcctcttccc agtctctagg attataggta
     4081 tgtgccacca tatctggctc ttagctcctt ctatatggag ttatctgtgc tagccaggta
     4141 cagtgtaata cacctttatt tccagtcttt aggaggcaga agtagataaa tcttaatcgg
     4201 aggcctgcct ggactatata gtgagttcta ggccagccac acctacatag atcttgttgt
     4261 gaaaggaaaa ataggaaaag agtacccaga ttggccttga acttaggatc tttatgtatc
     4321 agttgtatgc cactatgcct ggctcaaaat gccttttttt ttctttatta acttgagtat
     4381 ttcttattta catttcgatt ttttttaagt tatatatata tgtgatttct gcctgcatgt
     4441 atatgcacca tatgcatgcc tggttcccta ggagacagaa gagggtctca tatcctctta
     4501 gataggagtg agccactatg tgggtgttga gaatcagatc tggaagagta gtcagtgctc
     4561 ttaactgctg agccatctcc cacccttcaa aacatctttc taaagttgaa tttcttcccc
     4621 cccccctttt ctgtttagtc ctgactgttt cttgctggct tcaccctcta gtgctcacgt
     4681 tttgctagct ttgtgcaaaa acaggtgaac tgggtgatcc atcctcaatt ttacacattg
     4741 tgttgttcac atttctacaa ctttagcata catcaatatt gttttcattc aacaaacagt
     4801 tttggctcag gaactcgcta gagaactttg atagtggtgt gggatgagtt gatcagtata
     4861 gttttggata atgaatactg cacatgtata taaattactg gtctgggaca gcatcaggta
     4921 tacaaaaagg tgagtcttta gtgggcagtt agttaagtgg ttgagtgctg gtgaggaatc
     4981 catgaagccc tgggtttcca cggggggggg ggtaaggtaa atctgcagta ggaggggggg
     5041 gtaaggtaaa tctgcagtag gagggggggg taaggtaaat ctgcagtagg agggtgccat
     5101 taactgcttc atctgtggga aagactgtgg tcttggatga actgagttaa ctggccatgg
     5161 gcagcattgc aggaaataaa gctagaaagg ctttcgtttc gttaccaaga gtgcagatga
     5221 atgagcgtga gaactgtctt gtttagactg ccaagcattc atgactgtgt tagtattgcc
     5281 tgtgctggtg tatatttctt ctttgtgggc gttttagcaa gttgctcaca ctgttcaatt
     5341 tctcaccctt ttggagaaat caacattagt ctggctttaa agcccaaaac ataccatcta
     5401 atgacaagac ttccttagaa caaagcttag gaatgagcta cctttggatc acgtgggtct
     5461 cagtgccagg gagtaagcag ctcctgtgtc acttatatca aaaccttcca caggaataat
     5521 gtgctctggc tcctcattgt gcgtgacacc cttctcagag aaggaaaggt ctgtttttca
     5581 ggttcttatt ctgactcctg agagcccaag acgaagatgt aattgactga ctttagaagt
     5641 cagaattccc agaaattcaa ctaactgctc tagaaggtta aaatgtgaag tttcttgttt
     5701 gttttttgct tgtgctgaat attttgaatt ttcatctacc tcgtcttatt tttcttagtt
     5761 acttctgtca ttaccacttg agcatcaagc ttgattttgg tcattgtcta aaatggggtc
     5821 tctcctgttc agtgacagtt tattcccttg tctttcctct tggccctcat ttcacctaac
     5881 atcatctctt attgctcctg tcagaaatat gttttaaagt cttgttttat gggaaaaagt
     5941 ggtccaccaa tgctgtttgt ctctgaggtc agtgagagaa ggagttaaaa cacagtggtg
     6001 gaggaagggc agagcctgcc tgcactggag gcaaaagctg acaaggaagg agtcattaat
     6061 taaagacaat ttcaaagtca actgattgtg atcattaatg tcacaataga tcaaaaccta
     6121 attatcacag cctaggtaag agccatcagt attaatcgga aaatctaata ggaaactatt
     6181 agcaagaaat taggccaaat tgaatgcaat gaacttttta tcatcttttt ttggtaatgt
     6241 tcttggtgtt ggcaactgtg accctaacag ttggtccaag cccagattgc taattttaaa
     6301 gagccttttt tttttttttt tttaagtaac ccaggctgac cctagtgctt acagccctcc
     6361 agcttcagcc ttgagcactg ggattatgag gggtacatgc atttgtgttt gtgtgggtgg
     6421 gtaggagaga attgaactca gggccttgta cattttagac aagtgctcta ccactgaact
     6481 gtattcctag ctcagagtgt tttgtttgtt agggaagttt ccagacagac tgaacctaag
     6541 ctgacattgc tgaaacacca gccttgaatt tttttatcat atggatctat tcattctaat
     6601 cagatcagcg ggatataaac atatatatta aagtcgtaga gtgtccctag tgaacatcat
     6661 atcatctgtt gagtgcttgt atatagagtt ctatactggt tgttgtgaag gctgtgggag
     6721 gaaggcagtg tcctgctttg aaattctttg aaaactaaaa agatagtttc cttgtgtgac
     6781 agcatgatca agatgcaagt ctgtgttttt cagtttccat tagcattagg gtttgatcct
     6841 aaaccagctt agcagtgccc ccaaccccaa tagttttaag ataggcacaa aatgatttcc
     6901 tactggaatt ctaaggtatg gggaagacat ctttgtttct gttttccttt ctggtagtag
     6961 gagaagcatc agtatgtcct taagatgttt gtaaagatgc tacccccttt aggtgagatg
     7021 agtcaggctg tggaacggtt gctgtcacag gaggagtgcc aggcagtagt agagggaatt
     7081 gtgcttagga gtctgcactg tgccctgcag ccctcagatg ctcagtgctg accttaggag
     7141 gcccatgctg ctttctggac cttgggaacc tggattaccc agtagaagac tgagaatcaa
     7201 tgtcttttgt ttgtttgttt attttttgtt ctgtttttgt tttgttttgt tttgttttcc
     7261 aagatggggt ctctgtgtag ccatggatgt cctggaactt gctctgttga ccagactggc
     7321 ctcgaactca aagatctgcc tgcccctgcc tcccaagtac tgtgatcaaa cgtgtgcgcc
     7381 atcactgcct ggctaaccct tcacttctta gtgagtttta gtgtttaaaa aatgcaactt
     7441 aattttcaaa gtggcactaa ggtggtttgt ccagccttgg gttactccag gtgagcagca
     7501 gccctcaatt aacagtgtgt tgattggact catccggctg cagtgaaatg actgaaagtg
     7561 agatgttcta gtgcatagtt ctgtgctaac ctcctacttg gtcttaatgg ctgaccttgg
     7621 gcaagtcttt cctttcaatg cctcagttcc ccatctgtca aatggggtga taatactgac
     7681 ctacctcatg gggtgttgtg aggcattaca gatcagagct gatcaaccct ttaggattgc
     7741 ctgtggagga taccttaagt cggactcttt tagccctcac tgagctactt ccaagtttgg
     7801 aagtagttag tgaccttggc gagtttctgt ccccccaccc tttacccctc atcaaagctg
     7861 ctagttcaga tgttaacagt gttttgtgaa tgttggagtc ttgatcgtcc agtctaactt
     7921 gggacaatgt aagggaaggc acttgtgggt tctgtgtctt atattacaaa gagactgtta
     7981 gaaattcaag agccttggtt taggaatctt gaggcaggaa tgctaccgca tgtctttctc
     8041 tgcaggagtt aaggtcctat tctcatggac ttataactac ttctgactgt cttcgaaagg
     8101 aagtgacact tggtattttg gatttatatt gttgctttca ttttccagac tgatcctagg
     8161 acagttagtc tactgaaccc ttcatgcttc tatgcctctg ccctctcata gaagccagat
     8221 ggttcaagca acatagctct cccttccccc accaaaaagc tgtattggat ttttgttttt
     8281 ttgtttctag aaataggtgt aacatttcag aattgagcat tggtcctcaa ggcttcttcc
     8341 agttcactgt gtgtggaatc tgtcacctct tttcagtgtc caccatctga cccactgagg
     8401 acatcttgga cacttgtttg cccacttgag ggttcaaaag ccttactctg tgtttcagta
     8461 tagggctaag gcatccccaa gctcttcgtg ataggtttcc tttcccctac ttgaccttgt
     8521 attggtacca tgaaaaagca cacagtccta gctccctgga ggtacacact ccagtactgt
     8581 taggtggact ctactcctaa cagggatcct agagggttct ctggaggatg ggaaaggagc
     8641 agtctcatgt cctgccaagt agtagccagc agttgcctta cccctgcctg ctggccatgt
     8701 tcccacctcc tcatggagag ggctttcaga ggtcctcgag gctggatttt ctcagtctct
     8761 gctgtgccat tctgagtggg aagcagacca cactttgtgg ccaggtgtct aagtggaagt
     8821 gaggtcttga attctcggtg gactttttgg tttgtggggg agttttggtt gtgtttcttg
     8881 gttctatttc agccaaactc gcctgctttt gatttcttta aaggataagt ggtctatcta
     8941 tctatataca tgtatgtttg cattttaagt gtaaatgttt tgaaaaaaaa aaacagacat
     9001 gtctttctat aactgacatc cgattcagac atcattctct ccccttccac cctcttttcc
     9061 ctcttttcat actcttgtat tggttctaat aaaggattgc ttttcaaata tg
//
LOCUS       NM_001106789            4207 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus protein phosphatase 6, regulatory subunit 2
            (Ppp6r2), transcript variant 2, mRNA.
ACCESSION   NM_001106789 XM_001054912 XM_217014
VERSION     NM_001106789.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   Schmid,E.M., Ford,M.G., Burtey,A., Praefcke,G.J., Peak-Chew,S.Y.,
            Mills,I.G., Benmerah,A. and McMahon,H.T.
  TITLE     Role of the AP2 beta-appendage hub in recruiting partners for
            clathrin-coated vesicle assembly
  JOURNAL   PLoS Biol 4 (9), e262 (2006)
   PUBMED   16903783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced NM_001106789.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.29797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000007.1  122165048-122165258
            212-339             JAXUCZ010000007.1  122193494-122193621
            340-495             JAXUCZ010000007.1  122194723-122194878
            496-578             JAXUCZ010000007.1  122198007-122198089
            579-821             JAXUCZ010000007.1  122203808-122204050
            822-1008            JAXUCZ010000007.1  122207498-122207684
            1009-1146           JAXUCZ010000007.1  122210547-122210684
            1147-1212           JAXUCZ010000007.1  122213276-122213341
            1213-1325           JAXUCZ010000007.1  122216165-122216277
            1326-1439           JAXUCZ010000007.1  122216625-122216738
            1440-1566           JAXUCZ010000007.1  122218925-122219051
            1567-1719           JAXUCZ010000007.1  122220112-122220264
            1720-1935           JAXUCZ010000007.1  122223641-122223856
            1936-2000           JAXUCZ010000007.1  122225088-122225152
            2001-2116           JAXUCZ010000007.1  122226909-122227024
            2117-2202           JAXUCZ010000007.1  122228286-122228371
            2203-2300           JAXUCZ010000007.1  122229298-122229395
            2301-2358           JAXUCZ010000007.1  122229728-122229785
            2359-2480           JAXUCZ010000007.1  122230077-122230198
            2481-2644           JAXUCZ010000007.1  122230444-122230607
            2645-2801           JAXUCZ010000007.1  122231523-122231679
            2802-2890           JAXUCZ010000007.1  122231770-122231858
            2891-3086           JAXUCZ010000007.1  122232571-122232766
            3087-3314           JAXUCZ010000007.1  122235416-122235643
            3315-4207           JAXUCZ010000007.1  122235733-122236625
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4207
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="protein phosphatase 6, regulatory subunit 2"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
     exon            1..211
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            212..339
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..495
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..578
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    556..558
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="upstream in-frame stop codon"
     exon            579..821
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             595..3363
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein phosphatase 6 regulatory subunit
                     2; SAPS domain family, member 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 2 isoform 2"
                     /protein_id="NP_001100259.1"
                     /db_xref="GeneID:300146"
                     /db_xref="RGD:1563990"
                     /translation="MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKL
                     LDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESL
                     LNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILKHIGTS
                     ALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDI
                     IRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALL
                     EPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGV
                     LEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVE
                     LCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQ
                     KCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRG
                     LPAECRGRWESFVEETLMETNRRNTVDLAFSEYQIQQMTANFVDQFGFNDEEFADQDD
                     NINAPFDRIAEINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARV
                     MARARFGAPHTSENYSKKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDS
                     AGTTWTAVFDEPVNPLSAASGAARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETG
                     PRCSSPVDMDHSNAEGGQSPGPEKAFGPTSPCAWNVCVTRKAPLVASDSSSSGGSDSE
                     DDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRAECPDSTVLAPACPAPSEVTISPAV
                     ATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAIVATLGTMTKDRKTDALPD
                     GAALNGPV"
     misc_feature    976..2196
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    976..2196
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="SIT4 phosphatase-associated protein; Region: SAPS;
                     pfam04499"
                     /db_xref="CDD:398279"
     misc_feature    2446..>3333
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    2446..>3333
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     exon            822..1008
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1146
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1212
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1325
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1439
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1566
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1719
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1935
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2000
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2116
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2202
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2300
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2358
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2480
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2644
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2801
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2890
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3086
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3314
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..4207
                     /gene="Ppp6r2"
                     /gene_synonym="RGD1563990; Saps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggagc gatctcgccc gcggccccga gccggtcccg agcgggtccc gagcctcccg
       61 cccgctgcgc ccgagtccga aggcgccgcg ccgcggggcc gggcccatgt gcgtgcggcc
      121 cgctccaggc ggtccgcact tcacctctgg gagcgtcctg gcctccctcg ggcctcggag
      181 gagtcgccgc gacccccagc ctgcggggca ggtaaaccaa ccaaaactct ttgcagaatg
      241 aaaacacctt ttttaaaatt gcatgtatac aaaagaaaga gcccaaatgc tttttatttt
      301 gcctgaatac aagatttaaa caaggtattg ccatagaagt ctctaccaca gcgcgttctg
      361 ttggactctt tcacggaact ataggatcac atgggcagca cttgtgtttg attctaccct
      421 ctttcttccg gtcggttctg tcaccctggg aaatagagaa gcagaacgta cggctccttt
      481 cttcattcac tgctggatca atgtccaggg ccaaggcagt tttgtttgtg tggatttctg
      541 tttactgctg catggtagag gctgccgaac cccataagct ctgtgaccac catcatgttc
      601 tggaaatttg acttgaatac cacgtcccac gttgacaagc tcctcgacaa ggaacatgtg
      661 acactgcagg aattaatgga tgaagatgac atcttgcaag agtgtaaggc tcagaaccag
      721 aagctgctgg acttcctgtg caggcagcag tgtatggagg agctggtgaa cctcatcaca
      781 caagacccac cccaggacat ggaagagaag gtccgattca aatatccaaa cacagcctgt
      841 gagcttctga cttgtgatgt gccgcagatc agcgacagac taggcgagga cgagagtctg
      901 ctgaaccttc tgtatgactt cttggaccag gagccaccac tcaaccctct gcttgccagt
      961 ttttttagca agaccattgg caatctcatt gcaaggaaaa ccgaacaggt gatcatgttc
     1021 ttgaagaaga aggacaagtt catcagtctg atactgaagc acataggcac ctcagctctc
     1081 atggacctgc tgctacgcct ggtcagctgc gtggaaccag ttgttctccg gcaggaggtc
     1141 ctacattggc ttaatgaaga gaaagtcatc cagagacttg tggaattgat ccatccccac
     1201 caggatgaag ataggcagtc aaatgcttct caggcactct gtgacatcat caggctgggc
     1261 agagaccagg gcagtcagct gcaggagact gtggagccgg atcccctcct cacagcactg
     1321 gagtcgcagg actgtgtgga acagcttctg aagaacatgt ttgatgggga tcggacggag
     1381 agctgcctgg tcagtgggat gcaggtgctg cttgccctgc tggagccaag gcgtgttgga
     1441 acagaaggct tggtggactc cttttctcag ggactggaaa ggtcatactc tgtcagcagc
     1501 agcatcctgc acggcattga gccatggctg aagaatttcc atcagctcct gctcaaccca
     1561 ccaaagaaga aagcaatcct gaccactatt ggcgtgctag aggagcccct ggggaatgct
     1621 cgtcttcatg gtgcacgcct catggctgca ctgctgcaca caaatacgcc cagcatcaac
     1681 caggagctct gccggctcaa caccatggac ttactgctgg acctgttttt taagtacacc
     1741 tggaataact tcttacactt gcaagtggag ctgtgcatag ccgctattct ctcccacgct
     1801 ggtcgggagg agcaggcaga agctggcaga tcagatggca aagtggaacc tgtgcagggg
     1861 agtggagatg ggggtgggaa gccggagacc accccgtcca tcaccagccc tcctgagaac
     1921 acaatggtga cccatctgtt ccagaagtgc tgcctggttc agaggatcct ggaagcctgg
     1981 gaagccaatg acaacacaca ggcggcaggt ggcatgagac gtgggaatat gggccacctc
     2041 acaaggatcg ccaacgcagt tgtacagaac ctggagcagg gcccggtgca gacacacatc
     2101 agtgaagtca tccgagggct ccctgcagag tgccgtggac gctgggagag ctttgtggaa
     2161 gagacactga tggagaccaa ccgcaggaac actgtggacc tggccttctc tgagtaccag
     2221 atccagcaga tgacagcaaa ctttgtggat cagtttggct tcaatgatga ggagtttgca
     2281 gaccaggatg acaacatcaa tgccccattt gaccggattg cagagatcaa cttcaacatt
     2341 gaagccgatg aggacagtcc cagtgcagct ctgtttgaag cttgctgcag tgatcggatc
     2401 cagcccttcg atgatgacga ggaggacatt tgggaggatg aggagactcg atgcacggcc
     2461 cgggtgatgg ccagagccag gtttggagcc cctcacacct cagaaaacta ctcaaagaag
     2521 gccgtgggac atggaggcca gggcaggaag actggctccc ccacagctag gaatgtgcct
     2581 ggactggcca cgccttcatc ccctacacag aaagaaggtc ctcgctcaga aagtgattca
     2641 gcaggtacta catggacagc agtttttgat gagccagtga acccgctgtc tgcagcctca
     2701 ggagctgcga gggatgtggg ttctagtgca tgggcggctg gtccttcagt tgcagaggag
     2761 aaaggctggg ccaaattcac cgacttccag cctttctgct gctctgagac agggccccgg
     2821 tgcagctctc ctgtggacat ggaccacagc aatgccgagg gtggccagag tccaggccca
     2881 gagaaagcct ttggtcctac ctcgccttgt gcctggaacg tgtgtgtcac taggaaggcc
     2941 ccactggtag cctctgacag cagctcctct gggggatctg acagtgaaga tgacgagaag
     3001 gcagcgggtg ctgtggaagc tctgtgcgca ggccatactg gaaaggcctc cccgccaccc
     3061 aggacagcag aggctgctgc tggcagggcc gagtgtcctg acagcaccgt gttagcccct
     3121 gcctgccctg ctccttcaga agtgaccatc agtcctgccg tggctaccat agcaccaagc
     3181 aaggcaggct ctcccacagc caccatagtg gtctcttcct cagtggctac tgcggtaccc
     3241 ccaggaccaa tcatggcagt aaccacaaca gctccagcca tagttgcaac cctggggaca
     3301 atgacaaagg acaggaagac agatgccctg ccagatggag ctgccttaaa tggccctgtg
     3361 taatggctgc cgcccagcta tggcccaccc tggtcaggct gcctccttaa tcaagaagac
     3421 tacctggtga tgcaattttt tttaatttaa ctttaaaata aatgctgcat ttggtaaagc
     3481 tggcagtgga acccgttgga tgacccagct catgtttctc ctgcctgccc ttggtcctgt
     3541 tggaggacag gatgcacctg gccattccca ggcccaggtc ttggtgtggc aatgcagccc
     3601 tgacgcgcag cttcaacctg caggagttgg ggagggaaca agaccctaag gggccagcac
     3661 catcggatgg gcaggaaggg tgcggatctc caggcgctgg tttcatctgt atttttaacg
     3721 catggaggaa aagccgtttt ttgcactttg tacccagcta cagtacaggg tctctctagg
     3781 ctcagggcag atgtacaggc ctgagttgga gagacctgat ccccactaat aatactacat
     3841 gggggtctgg cactagtttg gccacatgag gtcaaacccc agttctagct gcccagggac
     3901 tcctgggagc tggtgttgaa tcaggctaca cattttgact gccttaaaaa caaagaccct
     3961 ctggacccgg tgcagtggtc tctgtgctca gcagggcaga ctggcacact cgggtggggg
     4021 ttggagctgc accagacatg taagagtgga cacggaagag cactgggagg cctagggacc
     4081 gggcgggccc atagtgtcca ggaagagtct aaagtctatg ttgtcttttt tttttttttt
     4141 ttttaaatgt tctgaccttc tgacagggca tctaaccccc aataaaaagg atcattctta
     4201 ctgaaaa
//
LOCUS       NM_001437795            1107 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family A, member 3 (Bpifa3),
            transcript variant 3, mRNA.
ACCESSION   NM_001437795 XM_006235362
VERSION     NM_001437795.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006235362.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1468411.1,
                                           SRR26360181.79486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000003.1  163069924-163070251
            329-479             JAXUCZ010000003.1  163073784-163073934
            480-587             JAXUCZ010000003.1  163075743-163075850
            588-737             JAXUCZ010000003.1  163077544-163077693
            738-822             JAXUCZ010000003.1  163078635-163078719
            823-886             JAXUCZ010000003.1  163079081-163079144
            887-1107            JAXUCZ010000003.1  163079636-163079856
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1107
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="BPI fold containing family A, member 3"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
     exon            1..328
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="upstream in-frame stop codon"
     CDS             202..921
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="BPI fold-containing family A member 3 isoform 3
                     precursor"
                     /protein_id="NP_001424724.1"
                     /db_xref="GeneID:690402"
                     /db_xref="RGD:1596102"
                     /translation="MHLLWRFLVLLLGLLALPSALPKQPWPGLTKAHKDGRSTLARII
                     AQGLLKHNAEGRIQSMRLLDRLNVSGTVAPGMVSWLISGMNFQQQQEISINITNVQLD
                     CGGIQMAFPKEWFSANITLEFDIEFKLPFNSNILKTHAQMGLAAESWLEKDEFGRRKL
                     VTGRCQMEPSSDSASMTTEAASPKMKNFLHNLRESLGKVIPNLVESQVCPLIGEILRQ
                     LDVKLLKGLVEQVAAHNLGQP"
     sig_peptide     202..261
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    340..858
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     misc_feature    340..858
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /note="LBP / BPI / CETP family, N-terminal domain; Region:
                     LBP_BPI_CETP; pfam01273"
                     /db_xref="CDD:396022"
     exon            329..479
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..587
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..737
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..822
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..886
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1107
                     /gene="Bpifa3"
                     /gene_synonym="Splunc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccaat gtgagctagc cctgggagca gctgccagag ccatttgtac cacctcccac
       61 agcatgctgg gggcagccgt gcagccacct gccggaagac agctgtaagc ccatcgatct
      121 gggtggccat actcacagcc aactgcctgg gccctgctgg accattactg acacctgcag
      181 gttcgggtgc cagcacttga gatgcaccta ctctggaggt tcctggtcct cctcctggga
      241 ttactagcct tgccctcagc cctgcccaag cagccttggc ctggactgac caaggcccac
      301 aaggatggcc ggtccaccct agcgagaatt attgcacagg gcctcctgaa gcacaatgca
      361 gaaggacgaa tccagagcat gcgtcttctg gaccgtctga acgtctcagg gacagtggcc
      421 ccagggatgg tgagctggct tattagtggc atgaacttcc agcagcagca agaaatcagt
      481 atcaacatta ccaatgtgca gctggactgt ggcgggatcc agatggcttt ccccaaagag
      541 tggttctccg caaacatcac acttgaattt gacattgaat tcaaactgcc cttcaattcg
      601 aatatcctca aaacccatgc ccagatgggc ctcgctgcag agtcctggct ggagaaagat
      661 gagttcggac ggaggaagct ggtgacaggc aggtgccaaa tggagcccag cagtgacagt
      721 gcatccatga ccactgaggc agcctcaccc aagatgaaga attttctcca caacctcaga
      781 gaaagcctgg ggaaagttat cccgaatttg gtagaaagtc aagtatgtcc tctgattggt
      841 gagatcctcc ggcagttgga tgtgaagcta ttgaaaggct tagtggaaca ggtggctgct
      901 cataaccttg gtcagccctg aatcagtcaa atctctgcta tcaggctcga ggggcctccc
      961 attgcctgcc attggtcaaa aggaggtact tctggttgag atcttacgtc tctctcagtg
     1021 tgtggcttct gctgtcccct ggaaaaatga cccccaggtc ccaagacatc ctgtcctttc
     1081 caacaataaa ctctaactct gaaggat
//
LOCUS       NM_001134619            3859 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus TELO2 interacting protein 1 (Tti1), mRNA.
ACCESSION   NM_001134619 XM_001068226 XM_006235428 XM_575280
VERSION     NM_001134619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   Fernandez-Saiz,V., Targosz,B.S., Lemeer,S., Eichner,R., Langer,C.,
            Bullinger,L., Reiter,C., Slotta-Huspenina,J., Schroeder,S.,
            Knorn,A.M., Kurutz,J., Peschel,C., Pagano,M., Kuster,B. and
            Bassermann,F.
  TITLE     SCFFbxo9 and CK2 direct the cellular response to growth factor
            withdrawal via Tel2/Tti1 degradation and promote survival in
            multiple myeloma
  JOURNAL   Nat Cell Biol 15 (1), 72-81 (2013)
   PUBMED   23263282
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Laplante,M. and Sabatini,D.M.
  TITLE     mTOR signaling in growth control and disease
  JOURNAL   Cell 149 (2), 274-293 (2012)
   PUBMED   22500797
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Apr 9, 2025 this sequence version replaced
            XM_006235428.5, NM_001134619.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.5105.1,
                                           SRR26643286.12046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000003.1  167102746-167102802 c
            58-2396             JAXUCZ010000003.1  167084389-167086727 c
            2397-2585           JAXUCZ010000003.1  167078896-167079084 c
            2586-2743           JAXUCZ010000003.1  167075878-167076035 c
            2744-2884           JAXUCZ010000003.1  167072684-167072824 c
            2885-3089           JAXUCZ010000003.1  167070574-167070778 c
            3090-3177           JAXUCZ010000003.1  167070201-167070288 c
            3178-3859           JAXUCZ010000003.1  167058989-167059670 c
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3859
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /note="TELO2 interacting protein 1"
                     /db_xref="GeneID:499935"
                     /db_xref="RGD:1562582"
     exon            1..57
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            58..2396
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3364
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /note="TEL2-interacting protein 1 homolog; Tel2
                     interacting protein 1 homolog"
                     /codon_start=1
                     /product="TELO2-interacting protein 1 homolog"
                     /protein_id="NP_001128091.1"
                     /db_xref="GeneID:499935"
                     /db_xref="RGD:1562582"
                     /translation="MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTA
                     LQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSA
                     CLYSPNSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLG
                     LAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALT
                     RVITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKVRAKPAVEHKVAALMIHRE
                     ADWVKSTGGKLAILIKKIIDCVSVHPHWKVRLELVEFVEVLLFKCSQSLVESTGPLLK
                     VLVGLVNDESSEVQAQCNTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQ
                     DDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVADVKMVEERR
                     WNSDNLSASAEASAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHF
                     MELYHTSIVYRKQAAMILNELVVGAAGLDVEDIHYECASTSPEELREIVKSILEEYTS
                     QENWYLITCIEAEEEEEVMMKQQGLQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIW
                     QICIQLEGIGQFAYALGKDFRLLLMSALYPVLEKAGDQTLLISQVAASTMVDICHACG
                     YNSVQHLINQNSDYLVNGISLNLRHLALHPHTPKVLEVMLRNSDASLLPLVADVVQDV
                     LATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQHSLEEVARQTPAASKAS
                     PTAEDIERFVLSYLQEKDMAEGNVSDLEAEEVLSEEQSVPPRVDESDALPDVEPPLPV
                     HIQIAKDVMERCIHLLSDKNLKVRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVH
                     RLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLASSLVTQAPISARAGPVY
                     SHTLAFKLQLAVLQGLGPLCESLDLGEGDLNKVADACLIYLSTKQPVKLQEAARSVFL
                     HLIKVDPDSTWLLLHQLHCPVQQFTAPHPSLHPVQWQGATKPQNPYATNVCHLLLQLQ
                     "
     exon            2397..2585
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2743
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2884
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3089
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3177
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3859
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcatttccg tctagggtgc tggaggcggg agagtggggg aaagactgga agacgagcct
       61 gcagaatgtt tcctcagtag gggaaagagg ttgtacaatg gcagtgtttg acactcccga
      121 ggaggctttt ggtgtcttac gtccagtctg cgttcagctc acaaagaccc agacagtgga
      181 gaacgtggaa catctgcaga cacagttaca agccataagt gacactgccc ttcaggaact
      241 acagcagtac attctcttcc ccttgcgatt tgccctgaag accccagggc ccaaaagaga
      301 gcgtctcgta cagagtgtgg tggaatgcct cacctttgtc ctctcttcaa catgtgtgag
      361 agagcaggag cttctccagg aactcttctc agaactttca gcttgtctgt actctcccaa
      421 ctcccagaaa cccgcagctt tgtcagagga gttaaaattg gctgtgatcc agggacttag
      481 caccttaatg cactcagctt acagggacat cattctgact ttttatgagc cctccattct
      541 gcctcgttta ggatttgctg tgtctttact gttgggcctg gcagagcagg agaagtcaaa
      601 acagattaaa attgctgcct tacagtgtct acaggttctc ctccttcaat gtgattgtca
      661 ggaccatcca aggcctttgg atgaactgga gcagcaacag ctgggggact tgttggcatc
      721 tttcttacct ggaatctcaa ctgcactgac cagagtcatc acaggagact ttaaacaagg
      781 tcatagcatt gtcgtgtctt ccctaaaggt cttctacaaa accgtgggct tcatcatggc
      841 tgatgaacag ctcacaagga tcccaaaggt gcgagcaaag cccgcagttg agcacaaagt
      901 agcagccctg atgattcaca gagaagcaga ctgggtaaaa agtactggtg gcaagttggc
      961 aatccttatt aaaaagataa ttgactgtgt ctctgttcat ccacactgga aggtgaggct
     1021 ggaactggta gagtttgtgg aggtcctgct ttttaagtgc agtcagtccc tggttgaatc
     1081 cacaggtccc ctcttgaagg tgttagttgg cctggtgaat gatgaaagtt ctgaagtgca
     1141 ggcccagtgc aatacagtgc taaggcgtct tgcagatcag aaggtagtag tgggcagcag
     1201 agccttggct gatatcttgt cagaaagcct gcattcattg gccacatctc ttccccgcct
     1261 gatgaacaca caagatgatc agggcaagtt ctctaccctt tccctgttac ttgggtatct
     1321 gaaactgttg ggccccaaag tacatgtaat tctcaattct gtggcccatg tgcagcgcct
     1381 ttccagggca ctcatccaag tattggagct agaggtggct gatgtcaaaa tggtggaaga
     1441 gcggcgatgg aattctgaca acctcagtgc ttctgcagag gcctcagctg cacggccatg
     1501 gagcagagtc cagaggcgat atttccgatg ctttactgac gagagggtct tcctgctcct
     1561 tcgaaagatc tgtcagcttc tgggttatta tggggacctg tatttgcttg tggatcactt
     1621 tatggaactg tatcatacat ctatagttta tcggaagcaa gctgccatga tccttaatga
     1681 actggttgta ggggctgctg gactggatgt ggaagatatt cattatgaat gtgcaagcac
     1741 gagcccagag gaattgagag agattgtgaa atctatacta gaggaataca cgagccaaga
     1801 aaactggtac ttgattacct gtattgaagc tgaggaggag gaggaggtga tgatgaagca
     1861 gcaaggcctc caggctgtca catctggtgt ccacacctgc caagttgtat cctttccagc
     1921 cctgtcaaag ccgagtccca ctatctgctc catgaacagt aacatctggc agatatgcat
     1981 tcagttggaa gggattggcc agtttgctta tgcactagga aaagactttc gtttgctttt
     2041 gatgtcagct ctctatccag tactagagaa ggctggagac caaaccttgc tcattagtca
     2101 agtggctgct agcaccatgg tagatatttg ccatgcttgt ggctataact ctgtacagca
     2161 cctgatcaat caaaattcag actatttggt gaatggaatc tctttaaatc tgcgtcacct
     2221 tgctctacac ccacataccc caaaagtcct ggaagtcatg cttcggaact cagatgctag
     2281 cctccttcct ttggtagcag atgtggttca agatgtcttg gccaccctgg accaatttta
     2341 tgataagaga gctgcatcct ttgtcagcgt tctgcacgct ctactggcag cattggcaca
     2401 ttggttccca gactcgggtt ctactgggca actccaacag cacagtttag aagaagtggc
     2461 gaggcaaacg ccagcagcta gcaaggctag ccccacagct gaggacatcg agcggtttgt
     2521 gctgagctat ctccaggaga aggatatggc agaggggaat gtttctgatc ttgaagctga
     2581 agaagttctt tcagaggagc agtctgtccc tcccagagtg gatgagagtg acgcccttcc
     2641 agacgtggag ccaccactgc cagtgcacat ccagatagcc aaggacgtga tggagcgctg
     2701 tatccacctg ttatcagata aaaacctgaa agtccgcctg aaggtcttgg acgtgctggg
     2761 attgtgtgtg gaagttctac agacccacaa gaaccagctt cttcccctgg ctcaccgagc
     2821 ctggccttca ctcgtgcacc gactcacaag tgatgacccc ctggcagtgc tcagagcttt
     2881 caaggttttg cagacccttg gaagcagatg tggcgatttt ctccggagcc ggttctgcaa
     2941 agatgtcctg ccaaaattgg ccagctcctt agtcacccag gcccccatca gtgccagggc
     3001 tggaccagtt tattctcaca cactggcctt caagctacag ctggctgtcc tgcagggcct
     3061 gggccccctc tgtgaaagtc tggacttagg tgagggtgac ctgaataaag tggctgatgc
     3121 ctgcttgatt tacctcagca ccaaacagcc cgtgaaatta caagaggctg ccaggagcgt
     3181 cttcctccac ctgataaagg tggaccccga ctccacctgg ctcctcctgc accagctgca
     3241 ctgccctgtg cagcagttca cagccccgca cccgagcctt cacccagtgc agtggcaggg
     3301 ggccactaag ccacagaacc cctatgccac caatgtttgc cacctgcttc ttcaactgca
     3361 gtgatcctgc cagaacctgc cagctaggag ctgagctgag ccacccctgc tggatacagt
     3421 tgcggcaaca cagagagcgg tgaaggtgga ttagacaacc accaatatat aaattgatcg
     3481 atcacacaac tgcttagaaa ttgggttgaa ggaaaagtcg cttactgtta cttatgtttc
     3541 actctttgtg ttttcagatg acattgattg gtggctctaa gagttcaact ctttagccta
     3601 ctgtctgcac agcccctctg ccacacaagt ccttcaaaca cacacaaaca cacacacaca
     3661 cacacacaca cacacacacc ccttgtgctc taagtccaag ttcgattctc agcacccatt
     3721 agtagctctc aaccgtccat gactccagtt tcaagggatc caaccccctc ctctgacctc
     3781 aagcaccaga cttgcacatg gtgcacagac actcatgagc caaacacata taagataaat
     3841 aaatcttttc aaaaatgtc
//
LOCUS       NM_001437792             744 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 20 open reading frame
            144 (C3h20orf144), transcript variant 2, mRNA.
ACCESSION   NM_001437792 XM_006235356
VERSION     NM_001437792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006235356.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.19793.1,
                                           SRR26360181.1434935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000003.1  163514345-163514523
            180-278             JAXUCZ010000003.1  163514755-163514853
            279-744             JAXUCZ010000003.1  163515018-163515483
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..744
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="similar to human chromosome 20 open reading frame
                     144"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
     exon            1..179
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..689
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C20orf144 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C20orf144 homolog
                     isoform 2"
                     /protein_id="NP_001424721.1"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
                     /translation="MGNSGSHKRTKAPNQASKDRPPDMDKARHKQFFSHLKRKKPSPT
                     ASQHATFPFFQWREAPDPARVGENPRIKAGKTKIVLLFPLDKRQQLAEAAAGPFVRPV
                     RPAEDPLGAPTCFPATVAPMLRGAGDGVDRREGARAREMKRILVLLLQLDARLQEEGR
                     RVAGRPGGGAKAQQYWQPLYAHLLTQREACGEGDPREEQPRKRRRCPRPRP"
     misc_feature    54..662
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     misc_feature    54..662
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     exon            180..278
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
     exon            279..744
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggcagg gctgaggcag catgggcagt ggcttctagt gaccagtcct atcatgggaa
       61 acagcggttc ccacaagagg accaaagcac ccaatcaggc cagcaaggac aggccacctg
      121 acatggacaa ggcccgtcac aagcagttct tcagccacct caagcggaag aagccaagtc
      181 ccacagcctc acaacatgcc actttcccct tttttcaatg gcgagaggct cctgaccctg
      241 cccgggtggg tgagaacccc cgcatcaagg ctgggaaaac caagatcgtg ctgcttttcc
      301 cgctggacaa gcggcagcag ctggccgagg cagcggcggg cccatttgtg cggcccgtgc
      361 ggcccgctga ggacccgctc ggcgccccga cgtgcttccc agccacggtg gcgcctatgc
      421 tacgtggggc aggcgacggc gtggacaggc gcgaaggtgc gcgcgcgaga gagatgaaaa
      481 ggatcctggt gctgctgctg cagctggacg cgaggctgca ggaggagggg cgtcgagtgg
      541 caggcaggcc ggggggcggg gccaaggccc agcagtactg gcagccgctg tatgcgcacc
      601 tgctgaccca acgcgaggcc tgcggcgaag gcgacccccg cgaggagcag ccgcgcaagc
      661 ggcgccgctg tcctcgcccg cggccctgag tgtctggcac gacccctaac gccaggactc
      721 tgctcaataa agagcacata gcaa
//
LOCUS       NM_001437722            8379 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus histone deacetylase 4 (Hdac4), transcript variant
            1, mRNA.
ACCESSION   NM_001437722 XM_063267466
VERSION     NM_001437722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8379)
  AUTHORS   Gu,X., Li,F., Che,X., Wei,X. and Li,P.
  TITLE     HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model
  JOURNAL   BMC Musculoskelet Disord 25 (1), 467 (2024)
   PUBMED   38879481
  REMARK    GeneRIF: HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8379)
  AUTHORS   Zhang,D., Du,J., Yu,M. and Suo,L.
  TITLE     Urine-derived stem cells-extracellular vesicles ameliorate diabetic
            osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering
            microRNA-26a-5p
  JOURNAL   Cell Biol Toxicol 39 (5), 2243-2257 (2023)
   PUBMED   35554780
  REMARK    GeneRIF: Urine-derived stem cells-extracellular vesicles ameliorate
            diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by
            delivering microRNA-26a-5p.
REFERENCE   3  (bases 1 to 8379)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7. PMID: 36806965]
REFERENCE   4  (bases 1 to 8379)
  AUTHORS   Moreno-Ruperez,A., Priego,T., Gonzalez-Nicolas,M.A.,
            Lopez-Calderon,A., Lazaro,A. and Martin,A.I.
  TITLE     Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm
            and Gastrocnemius Proteolytic Activity in Septic Rats
  JOURNAL   Int J Mol Sci 23 (7), 3641 (2022)
   PUBMED   35408999
  REMARK    GeneRIF: Role of Glucocorticoid Signaling and HDAC4 Activation in
            Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8379)
  AUTHORS   Wei,W., Chen,W. and He,N.
  TITLE     HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation
  JOURNAL   J Transl Med 19 (1), 258 (2021)
   PUBMED   34118928
  REMARK    GeneRIF: HDAC4 induces the development of asthma by increasing
            Slug-upregulated CXCL12 expression through KLF5 deacetylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8379)
  AUTHORS   Fischle,W., Dequiedt,F., Hendzel,M.J., Guenther,M.G., Lazar,M.A.,
            Voelter,W. and Verdin,E.
  TITLE     Enzymatic activity associated with class II HDACs is dependent on a
            multiprotein complex containing HDAC3 and SMRT/N-CoR
  JOURNAL   Mol Cell 9 (1), 45-57 (2002)
   PUBMED   11804585
REFERENCE   7  (bases 1 to 8379)
  AUTHORS   Lu,J., McKinsey,T.A., Zhang,C.L. and Olson,E.N.
  TITLE     Regulation of skeletal myogenesis by association of the MEF2
            transcription factor with class II histone deacetylases
  JOURNAL   Mol Cell 6 (2), 233-244 (2000)
   PUBMED   10983972
REFERENCE   8  (bases 1 to 8379)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   9  (bases 1 to 8379)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 8379)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063267466.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.50117.1,
                                           SRR26643284.12627.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000009.1  100197301-100197601 c
            302-540             JAXUCZ010000009.1  100164705-100164943 c
            541-612             JAXUCZ010000009.1  100076183-100076254 c
            613-854             JAXUCZ010000009.1  100050680-100050921 c
            855-1005            JAXUCZ010000009.1  100034333-100034483 c
            1006-1126           JAXUCZ010000009.1  100024695-100024815 c
            1127-1248           JAXUCZ010000009.1  100018481-100018602 c
            1249-1380           JAXUCZ010000009.1  100013993-100014124 c
            1381-1493           JAXUCZ010000009.1  100010352-100010464 c
            1494-1610           JAXUCZ010000009.1  100007494-100007610 c
            1611-1809           JAXUCZ010000009.1  100007207-100007405 c
            1810-2033           JAXUCZ010000009.1  100004898-100005121 c
            2034-2288           JAXUCZ010000009.1  99998890-99999144   c
            2289-2475           JAXUCZ010000009.1  99996052-99996238   c
            2476-2609           JAXUCZ010000009.1  99994292-99994425   c
            2610-2730           JAXUCZ010000009.1  99991723-99991843   c
            2731-2777           JAXUCZ010000009.1  99988140-99988186   c
            2778-2885           JAXUCZ010000009.1  99984745-99984852   c
            2886-2941           JAXUCZ010000009.1  99982715-99982770   c
            2942-3029           JAXUCZ010000009.1  99981864-99981951   c
            3030-3149           JAXUCZ010000009.1  99979516-99979635   c
            3150-3247           JAXUCZ010000009.1  99978680-99978777   c
            3248-3366           JAXUCZ010000009.1  99971610-99971728   c
            3367-3500           JAXUCZ010000009.1  99970072-99970205   c
            3501-3585           JAXUCZ010000009.1  99956805-99956889   c
            3586-3727           JAXUCZ010000009.1  99955846-99955987   c
            3728-8379           JAXUCZ010000009.1  99950972-99955623   c
FEATURES             Location/Qualifiers
     source          1..8379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..8379
                     /gene="Hdac4"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
     exon            1..301
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    63..65
                     /gene="Hdac4"
                     /note="upstream in-frame stop codon"
     exon            302..540
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..3767
                     /gene="Hdac4"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1; HD4"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 1"
                     /protein_id="NP_001424651.1"
                     /db_xref="GeneID:363287"
                     /db_xref="RGD:619979"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     AAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ
                     HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG
                     KESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQS
                     GVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVA
                     TALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVT
                     REGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHL
                     TPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHTQSLVGADRVSP
                     SIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKMIS
                     KPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEE
                     EVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRP
                     LSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQS
                     IWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSL
                     TSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPP
                     GHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVL
                     YMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVM
                     PIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEG
                     GHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEYWRCLQ
                     RLSPTVGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
     misc_feature    702..971
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    702..971
                     /gene="Hdac4"
                     /note="Glutamine-rich N-terminal helical domain of HDAC4,
                     a Class IIa histone deacetylase; Region:
                     ClassIIa_HDAC4_Gln-rich-N; cd10162"
                     /db_xref="CDD:197398"
     misc_feature    order(705..710,714..719,726..728,738..740,747..752,
                     759..764,768..773,780..785,789..794,801..809,813..821,
                     825..830,834..842,846..851,858..860,867..872,879..887)
                     /gene="Hdac4"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(705..710,714..719,726..728,738..740,747..752,
                     759..764,768..773,780..785,789..794,801..809,813..821,
                     825..830,834..842,846..851,858..860,867..872,879..887)
                     /gene="Hdac4"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(705..710,714..719,726..728,738..740,747..749,
                     759..761,768..770,780..785,789..794,801..806,813..815,
                     825..827,834..836,846..848,867..869,879..881)
                     /gene="Hdac4"
                     /note="dimer interface A, C [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(705..710,714..719,726..728,738..740,747..749,
                     759..761,768..770,780..785,789..794,801..806,813..815,
                     825..827,834..836,846..848,867..869,879..881)
                     /gene="Hdac4"
                     /note="dimer interface A, C [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(738..740,750..752,762..764,771..773,783..785,
                     792..794,804..809,816..821,828..830,840..842,849..851)
                     /gene="Hdac4"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(738..740,750..752,762..764,771..773,783..785,
                     792..794,804..809,816..821,828..830,840..842,849..851)
                     /gene="Hdac4"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(792..794,804..806,837..842,849..851,870..872,
                     882..887)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    order(792..794,804..806,837..842,849..851,870..872,
                     882..887)
                     /gene="Hdac4"
                     /note="dimer interface A, B [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    867..1454
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Interaction with MEF2A. /evidence=ECO:0000250"
     misc_feature    912..1019
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1128..1193
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1143..1145
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZM9; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1233..1499
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1251..1253
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1560..1577
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: PxLPxI/L motif, mediates interaction with ANKRA2
                     and 14-3-3 proteins.
                     /evidence=ECO:0000250|UniProtKB:P56524"
     misc_feature    1563..1565
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    1914..1916
                     /gene="Hdac4"
                     /note="Phosphoserine, by CaMK4 and SIK1.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2040..2108
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2142..2264
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2205..2207
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2385..2456
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2406..2408
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2409..2411
                     /gene="Hdac4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56524; propagated from
                     UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site"
     misc_feature    2457..3683
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    2457..3683
                     /gene="Hdac4"
                     /note="Histone deacetylase 4; Region: HDAC4; cd10006"
                     /db_xref="CDD:212530"
     misc_feature    order(2916..2921,2943..2948,3030..3032,3036..3038,
                     3312..3314,3432..3434)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    order(2916..2921,2943..2948,3030..3032,3036..3038,
                     3312..3314,3432..3434)
                     /gene="Hdac4"
                     /note="active site"
                     /db_xref="CDD:212530"
     misc_feature    3663..3764
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Nuclear export signal. /evidence=ECO:0000250"
     misc_feature    3687..3764
                     /gene="Hdac4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            541..612
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..854
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1005
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1126
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1248
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1380
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1493
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1610
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1809
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2033
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2288
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2475
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2609
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2730
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2777
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2885
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2941
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3029
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3149
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3247
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3366
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3500
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3585
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3727
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..8379
                     /gene="Hdac4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggctct gcgctcgagg gggagcagca tcatggttca acgtgggtca attttttgtg
       61 aatgaggagg ggaggttgtg gggccgctgc cgcggagcac catccccgcc gccgcccgag
      121 cccgagcccg cgcgcctgct cgcgccgccg ccgtcgccgc gccgcctcac gcccggcccg
      181 ctcaacgcga ctgctgtcgc cgtcgccgcc cgagcccgcc cgcccgccgg cggcggcgca
      241 ggctgaggag atgcggctcg gagcgcccga gcagggctag acgcggcccg ccgccgccgc
      301 ggttcatctc tgcaaggcca ggtgacaact tctgctcttc ttgtggatta cttggtttac
      361 aagacgctgc cagtgggact tcgagtttgc gcagctggga cccgggcctc ctcagttttg
      421 tacctgcatg ttctcgtggg aatttggagc gtgttggagc cactgtttac ctggacatct
      481 tgagccattt cgaacttaag gcactgacgc tgctagcaat gagctcccaa agccatccag
      541 atggactttc tggccgagac cagcctgtgg agctgctgaa tcctgcccgc gtgaaccaca
      601 tgcccagcac ggtggacgtg gctacagcgc tgcctctgca ggtggcccct gcagcagtac
      661 ccatggacct gcgcttggac caccagttct cactgccctt ggaacctgca ctgcgggagc
      721 agcaactgca gcaggaactc ctagcactga agcagaagca gcagatccag cggcagatcc
      781 tcattgcaga gttccagcgt cagcatgagc agttgtcccg acagcatgag gcacagctgc
      841 atgaacatat caagcagcag caggagatgc tggccatgaa gcaccagcag gagctgctgg
      901 agcaccagcg gaaactggag cggcaccggc aagagcagga gctggagaag cagcaccgtg
      961 agcagaagct gcagcagctc aagaacaagg agaagggcaa agagagtgct gtggcgagca
     1021 cagaggtgaa gatgaagctg caggagtttg ttctcaacaa gaagaaggct ctggcccacc
     1081 ggaacctgaa ccactgcatg tccagcgacc cccgctactg gtatgggaag acacagcaca
     1141 gctcccttga ccagagctct ccaccccaga gtggggtgtc agcctcctac aaccaccctg
     1201 tcttgggaat gtacgacgcc aaagatgact tccctcttag gaaaacagct tctgaaccta
     1261 acctgaaatt acggtcaagg cttaagcaga aagtagctga gagacggagc agccccctgc
     1321 tgcgcaggaa agatggccct gtggccactg ctctaaaaaa gcgacccctg gatgttacag
     1381 actccgcatg tagcagcgcc cctggctccg gtcccagctc ccccaatagc agctctggca
     1441 acgtcagcac cgagaatggc attgcaccca ccgtgcccag cactccagct gagacgagct
     1501 tggcacacag acttgtgact cgagaaggct ctgttgcccc acttcctctc tatacatcac
     1561 catccttgcc caacatcacc ctgggacttc ctgccactgg ccctgctgct ggtgcagcag
     1621 gccagcagga tgctgagagg cttgctctcc cagccctcca gcagcgaatc tccttgttcc
     1681 ctgggaccca cctcacccca tacctgagca cctcgcccct ggagcgggac ggtggagcag
     1741 ctcacaaccc cctcctgcag cacatggtcc tgctggagca gccacccacc cagacgcccc
     1801 ttgtcacagg cctgggggca ctgcccctcc acacacagtc cctggttggt gcggacaggg
     1861 tgtccccatc cattcacaag ctgcggcagc accgacctct ggggcgcacg cagtcagcac
     1921 ccctgccgca gaacgcacag gccctgcagc acctggtgat ccagcagcag caccagcagt
     1981 ttctggagaa gcacaagcaa cagttccagc agcagcagct gcacctcagc aagatgattt
     2041 ctaaacccag tgagccacct cggcagcctg agagccaccc ggaggagaca gaggaggagc
     2101 tccgtgaaca ccaggccttg ctggatgagc cctacctaga tcggctccct gggcagaagg
     2161 agccctcctt agctggtgtg caggtgaagc aggagcccat cgagagtgag gaggaagaag
     2221 tagaggccac tcgagaggcg gaacccagcc agcgcccagc cactgaacag gagcttctct
     2281 ttagacagca agctcttctg ctggagcagc agaggatcca ccagttaagg aactaccagg
     2341 catctatgga ggctgctggc atccctgtgt catttggcag ccacagacct ctgtctcgcg
     2401 cacagtcctc cccagcatct gccaccttcc ccatgtcagt ccaggagccc cccaccaaac
     2461 caaggttcac cacaggcctt gtgtatgaca cactcatgtt gaagcaccag tgcacctgtg
     2521 ggaacaccaa cagccacccg gagcatgctg ggaggatcca gagcatctgg tcccgcctgc
     2581 aggagactgg cctccgtggc aagtgtgagt gcatccgcgg acgcaaggcc acactggaag
     2641 agctgcagac agtgcactcg gaggcccaca cactcctcta tggcacaaac cctctcaaca
     2701 gacagaaact ggacagtaag aaacttctag gctcgctgac ctccgtgttt gtcaggcttc
     2761 cttgtggtgg tgttggggtg gatagtgata ccatatggaa tgaggtgcac tcgtctgggg
     2821 cagcccgcct ggctgtaggc tgtgtagtgg agctggtctt caaggtggcc acgggagagc
     2881 taaagaatgg ctttgctgtg gttcgtcccc caggacacca tgccgaggag agtacaccca
     2941 tgggtttctg ctactttaat tctgtggcaa ttgcagccaa acttctccag cagaggttga
     3001 atgtgagcaa gatcctcatt gtagactggg atgtgcacca tgggaatggg acccagcagg
     3061 ccttctacaa tgaccccaat gttctctaca tgtccctgca ccgctatgac gatgggaact
     3121 tcttcccagg aagtggagca ccagatgagg tgggcacagg gccaggcgtg ggtttcaatg
     3181 tcaacatggc cttcacgggt ggcctcgatc cccccatggg agacgccgag tacctggcag
     3241 ccttcagaac ggtggtcatg ccaatcgcaa atgagtttgc cccagatgtg gtactggtgt
     3301 cctcgggctt cgatgctgtg gagggccacc ccacacctct tggagggtac aatctctctg
     3361 ccaaatgttt cgggtacttg acaaaacagc tgatgggctt agctggtggc cggatcgtgc
     3421 tggccctgga gggaggccat gacctgacag ccatctgtga tgcttctgaa gcatgtgttt
     3481 ctgctctgct gggaaatgag cttgagcctc tgccagaaaa ggttctacat cagagaccca
     3541 atgccaatgc cgtccactcc atggagaaag tgatgggcat ccacagtgag tactggcgct
     3601 gcctgcagcg tttgtccccc actgtggggc actctctgat tgaggcgcag aagtgtgaga
     3661 atgaagaagc tgagacagtc accgccatgg cctcgctgtc tgtaggcgtc aaacctgctg
     3721 agaagagatc tgaggaggag cccatggagg aggagccacc actgtagccg aagctgctgt
     3781 tctctccttt gtctgtctgt cttaaggctc agccaagaaa ctttcccgtg tcactcctgc
     3841 gtcctgcctt ggtgctctct ctgagtgcga agggacagca ggtgtgaagc agcaacggga
     3901 ggcctttctg ccgccctgga ccacaggtct ggagacgcac acgaacacca ggtgtggcag
     3961 atcagatgga acacaggaca gtgcgcaaca cgtgggcaca cagacatgcc gcagaagcca
     4021 agcacacgct gctggggtcc cccaggaaag ccacgaagga agaagcttgt ggcaacttgg
     4081 gcagagttgc tgaattgagt tgacatgagg aaaatgaaaa tcaaagatct aataatacag
     4141 aacaaacttg attaaaactg gtgcttaaca tttgattctt acccacaatc ccacagtctc
     4201 cgtgtaaacc actcaactca tcttgtagct tttttaaaaa aaaaaaaaaa caagaaaaca
     4261 aaacagtttt ctatggctct ggcctgcctt gtgaacctta gtggggtgct gtgggggttc
     4321 acagcttagc gaggacggag ttggaagaaa cgtcaaagaa taaaaaacta gacagaacag
     4381 aaatgggagc ctgggagtca gctggagctt ctcgaagcca tcggaagatg cgagtttgtg
     4441 ccttttttta ttgctctgat ggaatttttt gtggctgggt tttctgaagt ctgaggaaca
     4501 atgccttaag aaaaaacaaa aacaaaaaca aaaaaacacc agtaagaatt ggtgtgacag
     4561 tgtcctgtgg ctggctgagt ctagtgatgc tggcctggca ttacaagagt ggcaccagcc
     4621 actgtccccg agggccgaag gacagccagc cagccttgct tggtttgatc accgtttaag
     4681 gaaggtgagg tagttccaaa aagcagcgaa cgccgccgcc gccggcagtt ttgaagtcta
     4741 acacgttttt aaacggatcc aaagtgttct ttcctcatcc gtcacatagc agttgagcat
     4801 ctccattcga ttgtgaagca tgtcgtaggc acattgcagt gttacgatcg gaatgctttt
     4861 cattaaaagc aggtagcatg aagtattgct taaattttag gtataaataa atatatatat
     4921 atatgtataa tatatattcc actgtattcc aagctaagaa acttgattct tatgagatct
     4981 tgataaaata tttataatgc atttatagac aaagtatata taaatatata taataaatcc
     5041 agaccgcaga ggtcctggca ggcgaaagac gtgtgtgtta gctctgaggt gctgagggct
     5101 gggtctggat tgaagcccat ggatttctga gctccagatt ggccagcttc cagattgcca
     5161 gcatgttcac ccctgggcaa tttccctacc agtttgtact ttaattttaa ttattttcta
     5221 acaaaacctc tgccctttcc aagcctccat gcacatatgt acctgatgag tttttatagc
     5281 aaaagatata aacttgctgt tgatttttgt atgaattttt cacaaaaaga tcctgaagaa
     5341 aacattattt tgtggatttt acatttttcc ccttaccatt cagcagtttt ctgaaggtgg
     5401 taatgtctga aactttttct ttctaaattc ttacttgtac atttttttta gctctgaagg
     5461 ttatttttat ggtttgattt tgtttctttt tgtacagcaa gcagggctct gctttgacca
     5521 ggaccgctgc tgtcatgctt ggttttttag agcaaacctc tcgagattgg gcagcaggtc
     5581 tgcgtggcac ccttgtcttg taaagctcac cgggagctgc acagccacgg gctcctgccc
     5641 cgcaacactc atagtattac aagggcgggc aggccgcatg agacacgagg gcagtcagca
     5701 tcaatgagcg tggacttgta accactccat caggatagaa ctccagctct agtttcccaa
     5761 agaccttcga ggcgagtcca caagcgcctg cccagagcct ggccctgcag ctgtcagcaa
     5821 tttccattgc ggcctcataa cctggactct ggctagagcc acagccctgg gtttgtagcc
     5881 tgtggctgct gaaccaaggc ctttgtcctt gtcctgcagg aacacatagg gtcctgaggg
     5941 acagtcagtc tttgtctttg ctcttttttt tttctatgac aactgacttt ttaactgcta
     6001 acttcttttc tagcacttaa agccaccaat ttcattccaa agtggagttc agactggcga
     6061 gaggaagttg agatactcag aagggacatc aagctaagtt tctgaatttg gtggcattta
     6121 cagggtagat gggaactggg tcaagctttt aaccaacagg ctgaacacac attcttggac
     6181 ttttgatcgc tgtgctgcta tgagtgctaa gctaagacag tgggtagaga ggtcttagga
     6241 catgcctgac tgtcctccct gtgtcccttc tggcccttgg cggaagggac aaacttgagg
     6301 gagccatgca gcctctccct tgcttgtcac tgcatggtga cagaggccag ctagctgctc
     6361 ttctggcctc cttggtccat tttctgcata ccctgccacc tgccctcttg tgccagccac
     6421 gactcgtggg agcatcatct taccttttca ggtgatgggt agcaggccac tcagtggcca
     6481 gggtactgtg agaggaactc actttggttc tattcagtca ccctttgatg caggggcctg
     6541 gccagggagc cagctcactc cagcttccct gggagctgaa agcattacct accatatagc
     6601 cttttctccc ctttgaagac aggtgtggtc cttcctcaca gtcatcaccc agggcagagg
     6661 gcagaaggtc ggccttgacc tccagggcag gaccacagca ctcccctgcc tggaccttga
     6721 accttccacc ttctcccttc ctttgcaaag gccttggtgg gtgctggcaa gggagccgga
     6781 gcaagcactt tacacccctt taaggggagc ccgaaggcac cgtgtcctca gggtgctggt
     6841 gttcgctcac ccttggggct tccacctgca ccctgagagc ccacgcccca ccagcaggcg
     6901 gctgttccca aggccaccac ctgctgggac atcccagggc tctggcttga gggctgcttt
     6961 atgaaagtgt ttcagttttt ctttattttc aaatctgtcc ccaagaggaa ggaccaccct
     7021 gtggtggtct ccgcagcact ggtgatgggc tcagtcatgt ttctttcctc agaacattcc
     7081 ttccttcttc actggtccca gccacgtgct cattccatcc ttctttttgt agactttggg
     7141 cccatgtatt ttatgggcat tgatacatat ataaatatat agatataaat atataaatat
     7201 atttttttaa gtttcctaca cctggaggtt gcatggacgt acgccggcat gtctttatat
     7261 tgtatacaga ttttgcacgc caaactcggc agctttgggg aaggagaagc attgcctttc
     7321 tctcccctct catgatgttt gcagatgcag aaattttttt ctgtaaaaca aaacaaaacc
     7381 ttgaaggaga agaggggggc gtttgagtct tactgaactt attcttaaga aattgtactt
     7441 tttattgtaa gaaaaataaa aggactactt ccacactcgt cattaagaaa agtttaccta
     7501 gcacctttga cataccgata gagagtcgat tgtatccaca cgcaagctcc acattcagac
     7561 cctgctgcct gtctgtcaag ctggctgggg gtgttttctt ttgttttgtt ggttttctcc
     7621 tctctctccc cgcacagggc caggtgcacc ctgcctgctg tcactggcct ctggtcgaga
     7681 acctgaggtt ctggtgagtc ctgtctcagc acaactgtgt cgatgggttc attccttcta
     7741 gaagacacgg ggctggggtt ctgcactggg caatccaggc ctttgtgagc cctaggtcta
     7801 aatgacactt ggcactggag gaaactattt ctccctctca aggatccagg tgtgctctgc
     7861 acccggcctt gatggcctca ccggccttga gttgatcaaa gtctactatg gaaagagaag
     7921 aatgcagaca ggccttgttc gggggtgtgc actccagtga ggaggtaccg tttcccgatc
     7981 tgtaagaatg ttaaacatgc tgttttcatg tatgcacagg aggctgacct ctgtcagcaa
     8041 gagctcacta cagaagtgtg gtccaagcca ccggagcgct gccacatgat gccgtgtgtg
     8101 ctccacagcc ttgaccgcct tcactctgta acagcctgtt ttctctttga ttgtctggac
     8161 ctcccctcct tggcgctttc tcctcctggc ggggttgggg gtcatgtttg gttttctcat
     8221 tcttgtttcg tttttttttt tgtgtgtgtg gtgggtttca ctgaccggcg gtgccctctg
     8281 gcggtcacct ctttccacct cccgggtcca gtgtttgtac cacatcacac acttgtcgct
     8341 ctcgtggtgt aaataaagac tgcgttaatt gccctccca
//
LOCUS       NM_001437725            2220 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RNA binding motif protein 43 (Rbm43), mRNA.
ACCESSION   NM_001437725 XM_063283541
VERSION     NM_001437725.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 2220)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063283541.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.881445.1,
                                           SRR26643292.12418.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000003.1  56813779-56813931   c
            154-272             JAXUCZ010000003.1  56811314-56811432   c
            273-462             JAXUCZ010000003.1  56809119-56809308   c
            463-542             JAXUCZ010000003.1  56805970-56806049   c
            543-2220            JAXUCZ010000003.1  56803587-56805264   c
FEATURES             Location/Qualifiers
     source          1..2220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2220
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA binding motif protein 43"
                     /db_xref="GeneID:311020"
                     /db_xref="RGD:1306676"
     exon            1..153
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            154..272
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    195..197
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="upstream in-frame stop codon"
     CDS             270..1301
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="rCG37778-like"
                     /codon_start=1
                     /product="RNA-binding protein 43"
                     /protein_id="NP_001424654.1"
                     /db_xref="GeneID:311020"
                     /db_xref="RGD:1306676"
                     /translation="MASALTVKDPTVSERTVVVSGLPVGLSKDQLVKRYFRDEGGHVE
                     KVIYPPRSKGVAYIIFKEKKVAQTIIRQKKHPLGSEPLLTVSHFSEKVFNYVMAILDL
                     SVFRPQIVLESLVVDLKKKIPTLNFSPLGRSGKISVQGSFLAILKLKQALISKAISAL
                     ENNRKYAGERRNWTGQNPRRVLQKNENSAPTLGTSVPEPAGSPETLVLDTDVFLYLKH
                     KCQFYEPTLSKYHVLCQERVDGDITTLCLQDARDGSYPGSVRHVKELIEEWAQEFYLE
                     LRKELLVLEGRRESEKRNMRQAFEQLCCRYPRVLMNVHRTHIDLIGPPSDTSLFKTQL
                     MKSAGQKVT"
     misc_feature    312..515
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    312..515
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    777..869
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            273..462
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            463..542
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
     exon            543..2220
                     /gene="Rbm43"
                     /gene_synonym="RGD1306676"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttttagg ccttcccgct gcctgagcat ctcctccctg cccaggcaag tagtttttcc
       61 cctggtttgc agtgcaggga ggcgcgccga gggtcccaaa gcatgagttc cgcgcggtcg
      121 cgcgccccga agtggccatc gcgggagcgg caggtaggac ctgcgtgcca tctcatcttg
      181 actcagctac tggttgaaag gacagcgatt ccgagaccct gcatcttctg ggccatcacc
      241 accaccgcct tagttttctg aattccacga tggcatcagc gttgacggtc aaagatccca
      301 cagtttctga gagaacagtt gtagtttctg ggcttccagt cggcctctca aaagaccagt
      361 tagtgaagcg ctacttccgg gatgagggcg gacatgtgga aaaggtgata tatccaccaa
      421 gatccaaagg agttgcgtat atcatcttca aggaaaagaa agttgcacag accatcatca
      481 gacaaaagaa acaccctcta ggctcagagc ctctgctcac agtctctcac ttcagtgaaa
      541 aggtcttcaa ctatgtgatg gccattcttg atttgtctgt ttttcggcct cagattgtgc
      601 tagaaagcct agtagtagac ctgaaaaaga aaatcccaac tttaaatttt agcccattgg
      661 gacgcagtgg gaaaatctct gtgcaaggtt catttctggc catcctgaag ctcaaacagg
      721 ctttgatatc aaaagctatt tccgctttag aaaacaacag gaaatacgct ggtgagagga
      781 gaaactggac tggacagaac cctagacggg tcctgcagaa aaacgagaac tctgcaccga
      841 ctctggggac ctctgtacct gagcctgccg gcagcccgga gacacttgtg cttgatacag
      901 atgtttttct ttacttgaaa cacaagtgtc agttttatga accaacgctg agcaaatacc
      961 atgtcctgtg tcaggaaagg gtggatggtg acatcactac cctttgtcta caagatgccc
     1021 gggatgggtc ttaccctggc agcgtcagac atgtgaagga gctcattgag gagtgggccc
     1081 aggagttcta ccttgagctc agaaaagagc tgctggtttt ggaaggaagg agagagagcg
     1141 agaaaagaaa catgaggcag gcttttgaac aactgtgttg cagatatcct agagttttga
     1201 tgaatgttca cagaacacat attgacctta taggacctcc ttctgacacg tccctgttta
     1261 agacacagct catgaagtct gcagggcaaa aggtcacttg aagtctcggc cacagttatc
     1321 atggtcactc cccccccgcc cctcccccac ccagggtgta ggtgaagatt tggatatgaa
     1381 gatatggata tgaaactact tatccgggct ggagagatgg ctcagcggtt aagagcaccc
     1441 gactgctctt ccagaggtca tgagttcaat tcccagcaac cacatggtgg ctcacaacca
     1501 tctgtaatga gatctgatgc cctcttctgg tgtatctgaa gacagctaca gtgtacttat
     1561 atataataaa tgaataaatc tttgaaaaaa aaaaaagaaa ctacttatcc aaagttatcc
     1621 agtagacagt gaatgggact ggcattgaat aaaaagtaat gtctaaatca agccttgaaa
     1681 aaaagaactc actaaatgtt gactgatttc ccctgcaaat caaaattatt aggagaagaa
     1741 gtcttccctt gcataggttt gcatgactag tgtgctgttg ctaagctctc ggggtttgta
     1801 ttcaccccac atagcattag aatgttggcc gagctcactt gggaagttgt ggttctgtca
     1861 gaattgtggg ggaatcttgg gagaagtctg tgtgaacgct tttgtgtgtg cttcttgctt
     1921 tccgatagta tggcatccag atgagcattg tgagtcgaaa acattgtgaa tcagaaatgc
     1981 ctttaattca agtagtttgc agaacatgct agatttgcca aactgcccac agtgaggaga
     2041 tgactgcgta cccgggttgc tgcgttgact gacagatagg ctcagtgatg ctgctctgca
     2101 ctgcttgaca gcattgggta gtggatcagc acttgtttgg aagagattca gtgttcgaag
     2161 tacgatttct actgactctt tattcctttt gcaccgtaat aaaggaaaac gtacagaaga
//
LOCUS       NM_001437791            1736 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family B, member 3 (Bpifb3),
            transcript variant 2, mRNA.
ACCESSION   NM_001437791 XM_006235352
VERSION     NM_001437791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1736)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   2  (bases 1 to 1736)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   3  (bases 1 to 1736)
  AUTHORS   Andrault,J.B., Gaillard,I., Giorgi,D. and Rouquier,S.
  TITLE     Expansion of the BPI family by duplication on human chromosome 20:
            characterization of the RY gene cluster in 20q11.21 encoding
            olfactory transporters/antimicrobial-like peptides
  JOURNAL   Genomics 82 (2), 172-184 (2003)
   PUBMED   12837268
REFERENCE   4  (bases 1 to 1736)
  AUTHORS   Dear,T.N., Boehm,T., Keverne,E.B. and Rabbitts,T.H.
  TITLE     Novel genes for potential ligand-binding proteins in subregions of
            the olfactory mucosa
  JOURNAL   EMBO J 10 (10), 2813-2819 (1991)
   PUBMED   1915264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006235352.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1434241.1,
                                           SRR22582424.718915.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000003.1  162861400-162861451
            53-178              JAXUCZ010000003.1  162862660-162862785
            179-335             JAXUCZ010000003.1  162863558-162863714
            336-440             JAXUCZ010000003.1  162865297-162865401
            441-581             JAXUCZ010000003.1  162865718-162865858
            582-645             JAXUCZ010000003.1  162867010-162867073
            646-706             JAXUCZ010000003.1  162868033-162868093
            707-798             JAXUCZ010000003.1  162868777-162868868
            799-978             JAXUCZ010000003.1  162868985-162869164
            979-1032            JAXUCZ010000003.1  162870558-162870611
            1033-1203           JAXUCZ010000003.1  162871907-162872077
            1204-1271           JAXUCZ010000003.1  162872549-162872616
            1272-1314           JAXUCZ010000003.1  162873464-162873506
            1315-1378           JAXUCZ010000003.1  162874203-162874266
            1379-1455           JAXUCZ010000003.1  162874705-162874781
            1456-1736           JAXUCZ010000003.1  162875570-162875850
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1736
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI fold containing family B, member 3"
                     /db_xref="GeneID:499924"
                     /db_xref="RGD:1565613"
     exon            1..52
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            53..178
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1485
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Potential ligand-binding protein RYA3; long
                     palate, lung and nasal epithelium carcinoma-associated
                     protein 3; Long palate, lung and nasal epithelium
                     carcinoma associated protein 3; antimicrobial peptide
                     RYA3"
                     /codon_start=1
                     /product="BPI fold-containing family B member 3 isoform 2
                     precursor"
                     /protein_id="NP_001424720.1"
                     /db_xref="GeneID:499924"
                     /db_xref="RGD:1565613"
                     /translation="MMPGVYALLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSL
                     VGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGLFSLVEELSGLKIEELTLPTV
                     SIKLLPGVGVQLSLHTKVSLHGSGPLVGLLQLAAEVNVSSKVALGMSPRGTPILILKR
                     CNTLLGHISLTSGLLPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVP
                     LGPLGSVEFTLATLPLISNQYIELDINPIVKSIAGDVIDFPKPRLPVKMPPKEDHTSQ
                     VTVPLYLFNTVFGLLQTNGALDLDITPEMVPRNIPLTTTDLAALAPEALGKLPPGQHL
                     LLSLRVMKSPMILLQNKKVTVSIPVTIHVLSSVPQGTPVALFQMNGVMTLNAHLVPST
                     TKLHISLSLERLTVQLASSFSQPFDASRLEEWLSDVVRAAYMQKLNEHLEVGIPLPKI
                     LNVNFANSVVDVIENAVVLTVAP"
     sig_peptide     64..123
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     124..1482
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /product="BPI fold-containing family B member 3.
                     /id=PRO_0000017172"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05701.1)"
     misc_feature    139..159
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI dimerizatation interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238164"
     misc_feature    139..159
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI dimerizatation interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238164"
     misc_feature    151..879
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     misc_feature    151..879
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     misc_feature    order(154..156,169..171,178..180,190..192,199..201,
                     382..384,493..495,499..501,529..531,658..660,670..672,
                     682..684,781..783)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    order(154..156,169..171,178..180,190..192,199..201,
                     382..384,493..495,499..501,529..531,658..660,670..672,
                     682..684,781..783)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    478..480
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05701.1); glycosylation site"
     misc_feature    880..1476
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP C-terminal domain; Region: BPI2;
                     smart00329"
                     /db_xref="CDD:128624"
     misc_feature    880..1476
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP C-terminal domain; Region: BPI2;
                     smart00329"
                     /db_xref="CDD:128624"
     misc_feature    order(898..900,913..915,922..924,934..936,943..945,
                     1120..1122,1219..1221,1225..1227,1252..1254,1360..1362,
                     1372..1374,1384..1386,1462..1464)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    order(898..900,913..915,922..924,934..936,943..945,
                     1120..1122,1219..1221,1225..1227,1252..1254,1360..1362,
                     1372..1374,1384..1386,1462..1464)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     exon            179..335
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            336..440
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..581
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..645
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..706
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..798
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..978
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1032
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1203
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1271
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1314
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1378
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1455
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1736
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggctggc aggaggctgg gaacccacct acagagcagg aggaacaggc tggtgtgcag
       61 ctgatgatgc cgggtgtgta cgccctgctt ctgctctggg gcctggccac gccgtgtctg
      121 gggctgcttg agacagtggg cacgcttgct cggattgaca aagatgagct gggcaaagcc
      181 atccagaact ccctagttgg gggtcccatt ctgcaaaatg tgctggggac cgtgacatca
      241 gtgaaccagg gtctcctggg cgcaggaggg ctgctcggag gtggtggact gctgagctac
      301 ggtggcctct ttagtcttgt ggaggaactc tctgggttga agatagagga actaaccttg
      361 cccaccgtgt caatcaagct gctgccgggg gttggggtgc agctgagcct gcacaccaag
      421 gttagcctgc atggctccgg tcccctggtg ggcctcctgc agctggccgc agaggtgaat
      481 gtgtcttcga aagtggcact gggcatgagc cctcggggga cacccatcct tatccttaag
      541 cgctgcaaca cgctcttggg ccacatcagc ctgacgtcag ggctgctgcc cacaccaatc
      601 tttgggcttg tggaacagac actgtgcaag gtgctgcctg gactgctgtg ccctgtggta
      661 gacagtgtgc tgagcgtggt gaatgagctc ttaggagcta cgctgagcct ggtacccctt
      721 gggcctctgg ggtctgtgga gttcactctg gccacactgc ccctaatctc caaccagtac
      781 attgagttgg atataaatcc catcgtgaag agcatagctg gtgatgtcat tgatttcccc
      841 aagccacgcc tcccagtcaa gatgcccccc aaagaggacc acacctccca agtgactgtc
      901 ccactctacc tcttcaacac tgtgtttggg ctcctgcaaa ccaatggtgc ccttgacctg
      961 gacatcaccc ctgagatggt tcccagaaat atcccgctga caactactga cctggcagct
     1021 ttggcccctg aggccctggg gaagctgccc cctggtcagc acctcctgct ctcgctgcgg
     1081 gtaatgaagt cacccatgat cctgctgcag aacaagaagg tcacagtctc tatcccagtc
     1141 accatccacg tgctgtcttc tgtccctcaa ggaactcctg tagctctttt ccagatgaat
     1201 ggagtcatga ctctaaatgc ccacctggtt ccatccacca ccaagctgca catatctctg
     1261 tccttggaac ggttgactgt ccagctggcc tcctcctttt cccaaccttt tgacgcatcc
     1321 cgtctagaag aatggctcag tgatgtggtc cgggctgcct acatgcagaa gctcaatgaa
     1381 cacctggagg ttggaatacc tctgcctaaa atcctcaacg tcaactttgc caattcagta
     1441 gtggatgtca ttgagaatgc ggtcgtgctc acagtggctc catgaggcag tatgactgca
     1501 gctcttcctg ttcactaaga gtcctatctg tctgcccgct ctgcctcagt ttccctccca
     1561 gcatgcattg gtggcagtat aagtactcct ctcccaccca ggcccacctt gccctctgtt
     1621 cctgtgatta tgactgtttg gggatggggt tgactggaca gccacagatc tgcttcagaa
     1681 agcacacagc accttggttc aggcccagcc tcaataaact gacccttggt cttgtg
//
LOCUS       NM_001437755            4459 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus tyrosine kinase, non-receptor, 2 (Tnk2),
            transcript variant 2, mRNA.
ACCESSION   NM_001437755 XM_039088304
VERSION     NM_001437755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Strochlic,T.I., Stavrides,K.P., Thomas,S.V., Nicolas,E.,
            O'Reilly,A.M. and Peterson,J.R.
  TITLE     Ack kinase regulates CTP synthase filaments during Drosophila
            oogenesis
  JOURNAL   EMBO Rep 15 (11), 1184-1191 (2014)
   PUBMED   25223282
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Hitomi,Y., Heinzen,E.L., Donatello,S., Dahl,H.H., Damiano,J.A.,
            McMahon,J.M., Berkovic,S.F., Scheffer,I.E., Legros,B., Rai,M.,
            Weckhuysen,S., Suls,A., De Jonghe,P., Pandolfo,M., Goldstein,D.B.,
            Van Bogaert,P. and Depondt,C.
  TITLE     Mutations in TNK2 in severe autosomal recessive infantile onset
            epilepsy
  JOURNAL   Ann Neurol 74 (3), 496-501 (2013)
   PUBMED   23686771
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Abdallah,A.M., Zhou,X., Kim,C., Shah,K.K., Hogden,C.,
            Schoenherr,J.A., Clemens,J.C. and Chang,H.C.
  TITLE     Activated Cdc42 kinase regulates Dock localization in male germ
            cells during Drosophila spermatogenesis
  JOURNAL   Dev Biol 378 (2), 141-153 (2013)
   PUBMED   23562806
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Shen,H., Ferguson,S.M., Dephoure,N., Park,R., Yang,Y.,
            Volpicelli-Daley,L., Gygi,S., Schlessinger,J. and De Camilli,P.
  TITLE     Constitutive activated Cdc42-associated kinase (Ack)
            phosphorylation at arrested endocytic clathrin-coated pits of cells
            that lack dynamin
  JOURNAL   Mol Biol Cell 22 (4), 493-502 (2011)
   PUBMED   21169560
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Prieto-Echague,V., Gucwa,A., Brown,D.A. and Miller,W.T.
  TITLE     Regulation of Ack1 localization and activity by the amino-terminal
            SAM domain
  JOURNAL   BMC Biochem 11, 42 (2010)
   PUBMED   20979614
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Shen,F., Lin,Q., Gu,Y., Childress,C. and Yang,W.
  TITLE     Activated Cdc42-associated kinase 1 is a component of EGF receptor
            signaling complex and regulates EGF receptor degradation
  JOURNAL   Mol Biol Cell 18 (3), 732-742 (2007)
   PUBMED   17182860
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Purification and enzyme activity of ACK1
  JOURNAL   Methods Enzymol 406, 250-260 (2006)
   PUBMED   16472662
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Yokoyama,N., Lougheed,J. and Miller,W.T.
  TITLE     Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual
            hydroxyamino acid specificity in a tyrosine kinase
  JOURNAL   J Biol Chem 280 (51), 42219-42226 (2005)
   PUBMED   16257963
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Eisenmann,K.M., McCarthy,J.B., Simpson,M.A., Keely,P.J., Guan,J.L.,
            Tachibana,K., Lim,L., Manser,E., Furcht,L.T. and Iida,J.
  TITLE     Melanoma chondroitin sulphate proteoglycan regulates cell spreading
            through Cdc42, Ack-1 and p130cas
  JOURNAL   Nat Cell Biol 1 (8), 507-513 (1999)
   PUBMED   10587647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039088304.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.29826.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  81641872-81642273   c
            403-583             JAXUCZ010000011.1  81639358-81639538   c
            584-654             JAXUCZ010000011.1  81637098-81637168   c
            655-876             JAXUCZ010000011.1  81634588-81634809   c
            877-1029            JAXUCZ010000011.1  81633460-81633612   c
            1030-1307           JAXUCZ010000011.1  81632731-81633008   c
            1308-1434           JAXUCZ010000011.1  81632129-81632255   c
            1435-1581           JAXUCZ010000011.1  81631579-81631725   c
            1582-1676           JAXUCZ010000011.1  81631398-81631492   c
            1677-1871           JAXUCZ010000011.1  81627329-81627523   c
            1872-1963           JAXUCZ010000011.1  81625109-81625200   c
            1964-2074           JAXUCZ010000011.1  81624334-81624444   c
            2075-3423           JAXUCZ010000011.1  81622398-81623746   c
            3424-3519           JAXUCZ010000011.1  81622212-81622307   c
            3520-3647           JAXUCZ010000011.1  81621930-81622057   c
            3648-4459           JAXUCZ010000011.1  81619795-81620606   c
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4459
                     /gene="Tnk2"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
     exon            1..402
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    286..288
                     /gene="Tnk2"
                     /note="upstream in-frame stop codon"
     CDS             325..3654
                     /gene="Tnk2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     activated CDC42 kinase 1; ACK-1; tyrosine kinase
                     non-receptor protein 2; activated p21cdc42Hs kinase"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 2"
                     /protein_id="NP_001424684.1"
                     /db_xref="GeneID:303882"
                     /db_xref="RGD:1305957"
                     /translation="MPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLE
                     LLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMC
                     KRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRL
                     LEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH
                     RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLE
                     SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL
                     KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
                     YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEG
                     RAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCW
                     GFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRMKREPPPRPPQPAIFTHSKWGC
                     SGCLGPRPLSPLSPLLEEPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARV
                     PGTKAGRSSGGEVTLIDFGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALP
                     RPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGETNYA
                     FVPEQAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQLTPSP
                     TPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQ
                     GSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCIL
                     PIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPA
                     APTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAARPADK
                     VQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEMFD
                     WNLEQAGCHLLGSCGPAHHKR"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    436..621
                     /gene="Tnk2"
                     /note="SAM domain of TNK(ACK)-like non-receptor
                     tyrosine-protein kinases; Region: SAM_TNK-like; cd09539"
                     /db_xref="CDD:188938"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    808..1581
                     /gene="Tnk2"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Activated Cdc42-associated kinase; Region: PTKc_Ack_like;
                     cd05040"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230,
                     1285..1299,1324..1326,1426..1428)
                     /gene="Tnk2"
                     /note="active site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(814..822,838..840,886..888,892..894,1033..1044,
                     1054..1056,1174..1176,1186..1191,1195..1197,1228..1230)
                     /gene="Tnk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1174..1176,1186..1188,1285..1299,1324..1326,
                     1426..1428)
                     /gene="Tnk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    order(1225..1257,1261..1305)
                     /gene="Tnk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270636"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    1603..1752
                     /gene="Tnk2"
                     /note="Variant SH3 domain; Region: SH3_9; pfam14604"
                     /db_xref="CDD:434066"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(1609..1611,1615..1617,1630..1632,1684..1686,
                     1690..1692,1735..1737,1741..1746)
                     /gene="Tnk2"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    1765..1962
                     /gene="Tnk2"
                     /note="GTPase binding; Region: GTPase_binding; pfam09027"
                     /db_xref="CDD:430374"
     misc_feature    <2269..3369
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2269..3369
                     /gene="Tnk2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2875..3051
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    2875..3051
                     /gene="Tnk2"
                     /note="EGFR receptor inhibitor Mig-6; Region:
                     Inhibitor_Mig-6; pfam11555"
                     /db_xref="CDD:463294"
     misc_feature    3412..3543
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3412..3543
                     /gene="Tnk2"
                     /note="UBA domain found in activated Cdc42 kinase 1 (ACK1)
                     and similar proteins; Region: UBA_ACK1; cd14274"
                     /db_xref="CDD:270460"
     misc_feature    3502..3621
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     misc_feature    3502..3621
                     /gene="Tnk2"
                     /note="UBA domain found in non-receptor tyrosine-protein
                     kinase TNK1 and similar proteins; Region: UBA_TNK1;
                     cd14328"
                     /db_xref="CDD:270513"
     exon            403..583
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..654
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..876
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1029
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1307
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1434
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1581
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1676
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1871
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1963
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2074
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..3423
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3519
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3647
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..4459
                     /gene="Tnk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcaag caggcggtgg ggggaagctg gggagtagga ccagagctgt gagcactgca
       61 ctggagacag gacagaggac ccagcctgtg accagctgtg gaaacccagc caggcttgca
      121 ggggagccaa gccaccactc cattcttctt ccctgtttcc tacttctgtg tgggatctga
      181 gggatttcta ggacctgttc cccctactct ctgggcagac catagaactc agaagctggg
      241 gcccttgcct gcccacttta gaacgaggcc atagctcctg tgacttaggg gcttcagctt
      301 gtggaggggc ttcagcttgt ggagatgcca gcagcccgtc gatttcctgg ccttgagctc
      361 tccttccctc tcctggccag actgcggcga cgactgtata caaggctggg gagcagcagc
      421 atgcagccgg aggagggaac aggctggctg ctggagctgc tgtctgaggt gcagctacaa
      481 cagtatttcc tgaggctccg agatgacctc aacattaccc gcctgtctca ttttgagtat
      541 gtcaaaaacg aagacctgga aaagattggc atgggccggc ctggccagag gcggctatgg
      601 gaggctgtga agaggaggaa ggccatgtgc aaacgcaagt catggatgag caaggtgttc
      661 agtggaaagc ggcaggaggc tgagttccct tcccatcact ctcagagcac cttccggaag
      721 ccctccccca ccccaggggg cctggcaggg gaggggaccc tgcagagcct cacctgcctc
      781 attggggaga aagacctgcg cctgctggag aagctgggag atggctcctt tggcgtggtg
      841 cgcaggggtg aatgggatgc ccctgcaggg aagacggtga gtgtggccgt gaagtgcctg
      901 aaacctgatg tgctgagcca gcccgaggcc atggacgact tcatccggga ggtcaatgcc
      961 atgcattcgc tagaccaccg aaacctcatt cgcttgtacg gtgtggtgct cacaccaccc
     1021 atgaagatgg tgacagagct ggcccctctg ggatccttgt tggaccggct acgtaaacac
     1081 caaggtcatt tcctcttggg gacgctgagt cgctatgccg tgcaggtggc tgagggcatg
     1141 ggctacctgg agtccaagcg cttcattcac cgagacctgg ctgctcgaaa tctgcttttg
     1201 gccacccgtg acctggtcaa gattggggac tttggactga tgcgagctct gccccagaat
     1261 gatgaccact atgtcatgca agaacatcgc aaggtgccct ttgcctggtg tgcccctgag
     1321 agcctgaaga cacggacttt ctcccatgcc agtgacacct ggatgtttgg ggtcacactg
     1381 tgggagatgt ttacgtatgg ccaggagccc tggattggcc tcaatggcag ccagatcctg
     1441 cataagattg acaaggaagg ggagcgcctg ccccggcctg aggactgccc ccaagacatc
     1501 tacaatgtca tggtccagtg ctgggcccac aagccagagg acagacccac atttgtggcc
     1561 cttcgggact tcctgctgga ggctcagcct acagacatgc gggcccttca ggacttcgag
     1621 gagccggaca agctgcacat ccagatgaac gacgtcatta ctgtcattga gggaagggct
     1681 gagaactact ggtggcgtgg tcagaacaca cggacgctgt gtgtgggacc cttccctcga
     1741 aatgtggtga cctctgtggc tggcctgtca gcccaggaca tcagccagcc tctacagaat
     1801 agcttcattc acacagggca tggcgacagt gacccccgcc actgctgggg gttccctgac
     1861 aggatcgatg aactgtacct gggaaacccc atggaccccc ctgacctgct gagtgtggaa
     1921 ctgagcacct cgcgacccac ccagcattta ggacggatga aaagggagcc tccacctcgc
     1981 ccacctcagc ctgccatctt cactcacagt aagtggggct gttcaggatg ccttggcccc
     2041 cgccctctct ctcctctctc tcctctcctg gaagagccaa catatgaccc tgtgagtgag
     2101 gacccagacc ccctgtccag cgacttcaag agacttggcc tgaggaagcc agccctgccc
     2161 cgagggctct ggctggcaaa gccctcagcc cgggtgccag gcaccaaggc aggccgcagc
     2221 agtgggggtg aggtcacact catcgacttc ggcgaggagc ctgtagcccc aaccccacgg
     2281 ccctgtgcac cttccttggc acagttggcc atggatgcct gctccctgct ggacaagaca
     2341 ccaccacaga gccccacacg ggcactgcca cgacctttac atcctacacc tgtggtggac
     2401 tgggacgctc gcccgctgcc cccgccccct gcctacgatg atgtggccca agatgaggat
     2461 gacttcgagg tgtgctctat caacagcacc ctagtgagtg caggcctccc taccgggcct
     2521 agccaaggcg agaccaatta tgcgtttgta cctgagcagg cccagctgcc ccctgccctg
     2581 gaggataacc tgttcctgcc accgcagggt ggaggccagc cacccagctc agcccagact
     2641 gcagagattt tccaggcact gcagcaggag tgtatgcggc agctacaggt ccccactggc
     2701 cagctgaccc cgtcccctac cccaggaggt gatgacaagc cccaggtgcc accccgggta
     2761 cctattcccc ctcggcccac acgtccacgt gtgggactat ctccagctcc cttaggtgag
     2821 gaagaggcaa gtcggtggcc tggaccctcc tcccctcccc gagtgcctcc ccgggaaccc
     2881 ctgtctcctc aagggtcgag gaccccaagc cccctagtac cacctggcag ctccccacta
     2941 ccgcatcggc tctcgagctc acctggaaag accatgccca ccacccagag ctttgcctca
     3001 gaccctaagt acgccactcc acaagtgatc caggctcctg gcccacgggc tggcccctgc
     3061 atcctgccca ttgtccgtga tggcaggaag gtcagcagca cccactatta cctgctgcca
     3121 gagcgccctc cctacctcga gcgctaccag cgcttcctga gggaggccca gagccccgag
     3181 gagccggccg ccctgcccgt tcccccactg ctgcccccgc ctagcactcc agcccctgcc
     3241 gcccccactg ccaccgtccg acctatgcct caggctgccc cagacccaaa ggccaacttc
     3301 tccaccaata acagcaaccc aggggcgcag ccaccatccc tgagggccag tgcacggctg
     3361 ccgcagaggg gctgcccagg ggatgggcaa gaggctgccc ggccagcaga caaagtccag
     3421 atgctgcagg ccatggtgca tggggtgacc acagaggagt gccaggcggc cctgaggagc
     3481 cacagctgga gtattcagag ggctgcccag tatctgaagg tggagcagct ctttgggctg
     3541 ggtcttcggc cacgggtgga gtgccacaaa gtgctagaga tgttcgactg gaacctagag
     3601 caagccggct gtcaccttct ggggtcctgt ggccctgccc accacaaacg ctgatggttg
     3661 actggagagc aatggtctgc cctaagagaa cctcttgaac ctgtctgtgg gacaagggtg
     3721 gggagatgcc ctgcctcagg cctggaggac ccacaactgc ctgcggctcc cagtggacag
     3781 tgagacccag gcagcaggag gctgggagcc tcaccttgcc cacctcgctc acccacccag
     3841 cgctgttctg cacaccttgg ttcagccctc agtgccccaa ccaagaggtg ggaagttcca
     3901 agccttgtga aggcaagaca ggaagctgcc tggcaggccc tgtgtgtgac ctgcctttgg
     3961 ccccagacca aggctgggct ggtggctaga gtgtgcccca ggctttccct gggggattag
     4021 actgagagga agccaggctt gacttggaca agaaggatgt gttggccaca cagaagggtg
     4081 ggccagcacc caacaggccc tcctcaggac caggcccctt tccagggaac ccctgtagga
     4141 atgtggagtg ttggacagaa tgtgacctgt ggcttcactg tgaactcggg cttggctggt
     4201 cttagatctt gtagctgtaa acagcctgaa gtggctcaga aacagaagag gcgccaggat
     4261 cttctctggc agggaccagg gccccaggcc ccgggtgtgg agggagaccc cagcggcacc
     4321 agtacttgtc ctgtttgatg cctgttcctc ccctgtgtcc atttgatgtg ttcccatcgc
     4381 ctctgttgcc aaagctgctg tcccagccat ggatatctgc ttcttccaga gaaataaagt
     4441 ctgtttctat tttacgtca
//
LOCUS       NM_001437772            1750 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus decorin (Dcn), transcript variant 1, mRNA.
ACCESSION   NM_001437772 XM_006241285
VERSION     NM_001437772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Hassan,G.M. and Ebrahim,R.H.
  TITLE     The myokine decorin improves the cardiac function in a rat model of
            isoprenaline-induced myocardial infarction
  JOURNAL   Can J Physiol Pharmacol 101 (6), 286-293 (2023)
   PUBMED   36917819
  REMARK    GeneRIF: The myokine decorin improves the cardiac function in a rat
            model of isoprenaline-induced myocardial infarction.
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Gaspar,R., Gomori,K., Kiss,B., Szantai,A., Paloczi,J., Varga,Z.V.,
            Pipis,J., Varadi,B., Agg,B., Csont,T., Ferdinandy,P., Bartekova,M.
            and Gorbe,A.
  TITLE     Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury
  JOURNAL   Molecules 25 (15), 3426 (2020)
   PUBMED   32731559
  REMARK    GeneRIF: Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Lai,J., Chen,F., Chen,J., Ruan,G., He,M., Chen,C., Tang,J. and
            Wang,D.W.
  TITLE     Overexpression of decorin promoted angiogenesis in diabetic
            cardiomyopathy via IGF1R-AKT-VEGF signaling
  JOURNAL   Sci Rep 7, 44473 (2017)
   PUBMED   28290552
  REMARK    GeneRIF: overexpression of decorin ameliorated diabetic
            cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF
            signaling pathway in vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   De Cosmo,S., Tassi,V., Thomas,S., Piras,G.P., Trevisan,R., Cavallo
            Perin,P., Bacci,S., Zucaro,L., Cisternino,C., Trischitta,V. and
            Viberti,G.C.
  TITLE     The Decorin gene 179 allelic variant is associated with a slower
            progression of renal disease in patients with type 1 diabetes
  JOURNAL   Nephron 92 (1), 72-76 (2002)
   PUBMED   12187087
REFERENCE   7  (bases 1 to 1750)
  AUTHORS   Schaefer,L., Raslik,I., Grone,H.J., Schonherr,E., Macakova,K.,
            Ugorcakova,J., Budny,S., Schaefer,R.M. and Kresse,H.
  TITLE     Small proteoglycans in human diabetic nephropathy: discrepancy
            between glomerular expression and protein accumulation of decorin,
            biglycan, lumican, and fibromodulin
  JOURNAL   FASEB J 15 (3), 559-561 (2001)
   PUBMED   11259366
REFERENCE   8  (bases 1 to 1750)
  AUTHORS   Asundi,V.K. and Dreher,K.L.
  TITLE     Molecular characterization of vascular smooth muscle decorin:
            deduced core protein structure and regulation of gene expression
  JOURNAL   Eur J Cell Biol 59 (2), 314-321 (1992)
   PUBMED   1493796
REFERENCE   9  (bases 1 to 1750)
  AUTHORS   Abramson,S.R. and Woessner,J.F. Jr.
  TITLE     cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin)
  JOURNAL   Biochim Biophys Acta 1132 (2), 225-227 (1992)
   PUBMED   1390895
REFERENCE   10 (bases 1 to 1750)
  AUTHORS   Kokenyesi,R. and Woessner,J.F. Jr.
  TITLE     Purification and characterization of a small dermatan sulphate
            proteoglycan implicated in the dilatation of the rat uterine cervix
  JOURNAL   Biochem J 260 (2), 413-419 (1989)
   PUBMED   2764879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006241285.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF110991.1, FQ223184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               JAXUCZ010000007.1  34170772-34170929
            159-378             JAXUCZ010000007.1  34171780-34171999
            379-491             JAXUCZ010000007.1  34183041-34183153
            492-705             JAXUCZ010000007.1  34194575-34194788
            706-819             JAXUCZ010000007.1  34195743-34195856
            820-913             JAXUCZ010000007.1  34200078-34200171
            914-1052            JAXUCZ010000007.1  34203914-34204052
            1053-1750           JAXUCZ010000007.1  34207307-34208004
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1750
                     /gene="Dcn"
                     /note="decorin"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
     exon            1..158
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    15..17
                     /gene="Dcn"
                     /note="upstream in-frame stop codon"
     exon            159..378
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1247
                     /gene="Dcn"
                     /note="dermatan sulfate proteoglycan-II (decorin); DSPG;
                     PG40; PG-S2; bone proteoglycan II"
                     /codon_start=1
                     /product="decorin precursor"
                     /protein_id="NP_001424701.1"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
                     /translation="MKATLVLFLLAQVSWAGPFEQRGLFDFMLEDEASGIIPYDPDNP
                     LISMCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKDL
                     HTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKL
                     KKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLPTSI
                     SELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKL
                     LRVPAGLAQHKYVQVVYLHNNNISEVGQHDFCLPSYQTRKTSYTAVSLYSNPVRYWQI
                     HPHTFRCVFGRSTIQLGNYK"
     sig_peptide     183..230
                     /gene="Dcn"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     273..1244
                     /gene="Dcn"
                     /product="Decorin. /id=PRO_0000032720"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1)"
     misc_feature    282..284
                     /gene="Dcn"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000269|PubMed:2764879; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    324..422
                     /gene="Dcn"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    324..422
                     /gene="Dcn"
                     /note="Leucine rich repeat N-terminal domain; Region:
                     LRRNT; smart00013"
                     /db_xref="CDD:214470"
     misc_feature    351..413
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    351..413
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    384..446
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 1"
     misc_feature    414..>1088
                     /gene="Dcn"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    414..>1088
                     /gene="Dcn"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    414..485
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    414..485
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    447..518
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 2"
     misc_feature    486..557
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    486..557
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    519..590
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 3"
     misc_feature    558..620
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    558..620
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    591..653
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 4"
     misc_feature    621..692
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    621..692
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    654..725
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 5"
     misc_feature    693..770
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    693..770
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    726..803
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 6"
     misc_feature    771..833
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    771..833
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    798..800
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    804..866
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 7"
     misc_feature    834..905
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    834..905
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    867..938
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 8"
     misc_feature    903..905
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    906..977
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    906..977
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    939..1010
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 9"
     misc_feature    951..953
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    1011..1079
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 10"
     misc_feature    1047..1106
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1047..1106
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1074..1076
                     /gene="Dcn"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q01129.1); glycosylation site"
     misc_feature    1080..1169
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 11"
     misc_feature    1116..1199
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1116..1199
                     /gene="Dcn"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1170..1244
                     /gene="Dcn"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01129.1);
                     Region: LRR 12"
     exon            379..491
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            492..705
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            706..819
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            820..913
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1052
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1750
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaaaacac attataacat gtgataagtt cattaaaaga ggtcagagta tcgttctcag
       61 atcacagaag aggcaacgag caggctcctg ctcggaggag tcaggagata caggggagaa
      121 acccagactc tcacgtaatc tgtaaacttc ttcagaaggt ggtgaaaacg catgagacaa
      181 ccatgaaggc aactctcgtc ttattccttc tggcgcaagt ctcttgggct ggaccatttg
      241 agcagagagg attatttgac ttcatgctag aagatgaggc ctctggcata atcccttacg
      301 accctgacaa tcccctgata tctatgtgcc cctaccgatg ccaatgccat ctccgagtgg
      361 tgcagtgttc tgatctgggt ctggacaaag taccctggga atttccacct gacacaacat
      421 tgctagacct gcaaaacaac aaaataacag agatcaaaga gggggccttt aagaacctga
      481 aggacttgca taccttgatc cttgtcaaca acaagatcag caagatcagc ccagaggcat
      541 ttaaacctct agtgaagttg gaaaggcttt atctgtctaa gaaccaccta aaggagctgc
      601 ccgaaaaatt gcccaaaaca ctccaggagc ttcgactcca cgacaatgag atcaccaaac
      661 tgaagaaatc tgtgttcaat ggactgaacc gtatgattgt catagaactg ggcggcaacc
      721 cactgaaaaa ctctgggatt gaaaatggag ccttgcaggg aatgaagggt ctcggataca
      781 tccgcatctc agacaccaac ataactgcta ttcctcaagg tctgcccact tctatcagtg
      841 aactgcatct ggatggcaac aagatcgcca aagttgatgc agccagcctg aaaggaatgt
      901 ctaatttgtc taagctgggt ttgagcttca atagcatcac cgttgtggaa aatggcagtc
      961 tggctaatgt tcctcatctg agggagctcc acttggacaa caacaaactc ctcagagtgc
     1021 ctgctgggct ggcacagcat aaatatgtcc aggtcgtcta ccttcataac aacaacatct
     1081 ccgaagttgg gcagcatgac ttctgcctcc cttcatacca gactaggaag acttcctaca
     1141 ctgccgtgag tctttatagc aaccctgtcc ggtattggca aattcaccca cacaccttca
     1201 gatgtgtctt cgggcgctct accattcaac ttgggaacta caagtaactc ccaaacagcc
     1261 tcatttttat aatcgggaac aaaaaaacca atctgtcaat attattgcta aaaagaaaaa
     1321 aatattttga aaaagaaaga atgctagatt ctggaaattc aagtatagcg cggatgcctt
     1381 tcccgtatga cttatcatgc atcaagccaa atatacagat tgaataatta cctacaataa
     1441 aaatatttta tctgtagtat tcagaatcac ttttaaaatt ttctgtagat gtgaactgag
     1501 gtatcgaagt ctggtgtaat catagatgtc aacatttaat aaagctaaaa ggaacagaat
     1561 acaaagtctt ctgtaattca tagagctaaa ttgactcttt tgacataaag tcaaatgtag
     1621 aactctagca atgtattaat ctcctttatt attggtaaag tcttatttga atatctaagt
     1681 tcaacatggg ctatgtaaaa ttttcactgt catactgaaa aacaataaaa tttaaaaaat
     1741 gcattcaaaa
//
LOCUS       NM_001437748            4023 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 9 member C1 (Slc9c1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437748 XM_017597925
VERSION     NM_001437748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4023)
  AUTHORS   Wang,D., King,S.M., Quill,T.A., Doolittle,L.K. and Garbers,D.L.
  TITLE     A new sperm-specific Na+/H+ exchanger required for sperm motility
            and fertility
  JOURNAL   Nat Cell Biol 5 (12), 1117-1122 (2003)
   PUBMED   14634667
REFERENCE   2  (bases 1 to 4023)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_017597925.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.542339.1,
                                           SRR26643293.69081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000011.1  68740757-68740859   c
            104-234             JAXUCZ010000011.1  68739393-68739523   c
            235-488             JAXUCZ010000011.1  68738514-68738767   c
            489-589             JAXUCZ010000011.1  68737292-68737392   c
            590-718             JAXUCZ010000011.1  68735441-68735569   c
            719-884             JAXUCZ010000011.1  68734127-68734292   c
            885-1010            JAXUCZ010000011.1  68731230-68731355   c
            1011-1172           JAXUCZ010000011.1  68729739-68729900   c
            1173-1272           JAXUCZ010000011.1  68727024-68727123   c
            1273-1416           JAXUCZ010000011.1  68725462-68725605   c
            1417-1591           JAXUCZ010000011.1  68724252-68724426   c
            1592-1673           JAXUCZ010000011.1  68722851-68722932   c
            1674-1840           JAXUCZ010000011.1  68721131-68721297   c
            1841-1966           JAXUCZ010000011.1  68719387-68719512   c
            1967-2064           JAXUCZ010000011.1  68710052-68710149   c
            2065-2184           JAXUCZ010000011.1  68707948-68708067   c
            2185-2380           JAXUCZ010000011.1  68705164-68705359   c
            2381-2566           JAXUCZ010000011.1  68702161-68702346   c
            2567-2716           JAXUCZ010000011.1  68700108-68700257   c
            2717-2768           JAXUCZ010000011.1  68698708-68698759   c
            2769-2917           JAXUCZ010000011.1  68697254-68697402   c
            2918-3043           JAXUCZ010000011.1  68693952-68694077   c
            3044-3142           JAXUCZ010000011.1  68692683-68692781   c
            3143-3325           JAXUCZ010000011.1  68689006-68689188   c
            3326-3457           JAXUCZ010000011.1  68682499-68682630   c
            3458-3643           JAXUCZ010000011.1  68682196-68682381   c
            3644-3770           JAXUCZ010000011.1  68680194-68680320   c
            3771-3823           JAXUCZ010000011.1  68676184-68676236   c
            3824-4023           JAXUCZ010000011.1  68674380-68674579   c
FEATURES             Location/Qualifiers
     source          1..4023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4023
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="solute carrier family 9 member C1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
     exon            1..103
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            104..234
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            235..488
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    326..328
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="upstream in-frame stop codon"
     CDS             341..3886
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="isoform 1 is encoded by transcript variant 2;
                     sperm-specific sodium proton exchanger; sodium/hydrogen
                     exchanger 10; solute carrier family 9, member 10; solute
                     carrier family 9, subfamily C (Na+-transporting carboxylic
                     acid decarboxylase), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 10 isoform 1"
                     /protein_id="NP_001424677.1"
                     /db_xref="GeneID:288117"
                     /db_xref="RGD:1309075"
                     /translation="MEEVFENLTTTHNVKLSNAWLDLLKSVFLSTPQDLPEIILILSL
                     ICTIGAFLNMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFFGI
                     FTPVIIFNVAFDMDIYMLQKLFWQILLITIPGFMINYTLILWYLQSVNKLSLKTIPWL
                     LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKH
                     MNHTLAHKVMSTAWSYLVESFITGILITKAIQLWMATIFGDDVNHITLIFSVLYLIFY
                     VCELIGMSGIFTLATIGLFLNSTSFKPGVEAFLLEFWNCLSFIGFLMVFTFIGLLIPA
                     HTYLYISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWRWAFIMVWSEMKG
                     TPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIVNRFILPMAVIKLGLRDVT
                     STKYKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTE
                     HQKVKCPDCNKEIDETLNIEAMELANRRLLSAQIASYQRQYRNEILSQSAMQVLVGAA
                     GSFGEKKGEYMSPENIKNYSESKKLLSFLRKLLLNWVYNTKKDKGVPSRYMFLHACHS
                     IVFTNEFEYTGYIAVLMNTYPMIICWISRLKDIYQYEIKCANYYFLTFYILEALLKVA
                     AMRKEFFSHTWLLFELGITLVGILDIILIETDSISYKFDLTETVVFMNVVRLLRILRI
                     LKLITPKLLQVIDKRMSQQISFRYAILKGYVQGEMDVLNIIDQIASSKQAKQILLKRV
                     IRNMDHAMKELGYLEYDHPEIAVTMKTKEEVNVMLNMAREIVKAFRSKGIIHKVEGAE
                     INKLIMAKKKQVLELQSVIQPLNVEEAPYYIPWLSEDPEAISFIQEKAKVVTFDCGNN
                     IFEEGDEPEGIYVIISGMVKLKRSKPHLEMDRVSSESEVAQTRSYTLPHTEYLLSGEI
                     IGELNCLTKERMQYSATCKTVVETYFIPISHLYEGFEKKYPNMKYKMWQKIGLAITAQ
                     KIRENLSFEDWNYKMQLKLCNVFVRDIPKTTKTDIYDETVTHVVLIHGSAEDCQLRKI
                     YKAPFLIPVTCHQIQGLEEFTKVMIIQTSVAVRKFRWNVKKYNPPRRISMKPDSTESL
                     ETLNESSEDDEDKKENEENEEYLEDIIDISSVSKK"
     misc_feature    449..2008
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    449..2008
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion
                     transport and metabolism]; Region: NhaP; COG0025"
                     /db_xref="CDD:439796"
     misc_feature    3017..3400
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    3017..3400
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(3260..3265,3290..3298)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3260..3265,3290..3298)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3356..3364,3377..3385)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(3356..3364,3377..3385)
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            489..589
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            590..718
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            719..884
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1010
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1172
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1272
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1416
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1591
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1673
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1840
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1966
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2064
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2184
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2380
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2566
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2716
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2768
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2917
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3043
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3142
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3325
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3457
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3643
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3770
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3823
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4023
                     /gene="Slc9c1"
                     /gene_synonym="Gm610; Slc9a10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtcagt gaggttgcag ttggttttgg acagttctgg agtgagagga agttcctggc
       61 ctccacttct cacattctct aggacactcc tgtgccctgg atgctttcca agtgattcat
      121 gctactgctg agatggagtc ttactggaca gacatagctg agagccgttg ctctatttcc
      181 agatcaacct caagctcttg ttttcttttg tgattttttt tttattattt tgagaagggc
      241 attaggaaga caccaagaag aaaagtccta ttccctttga tcccctgtga gtttttcaga
      301 gacacagagt ttgagacgct gactgtaatt aaatacggga atggaagaag tttttgagaa
      361 tctaactaca acccacaatg tcaaactgag taatgcatgg ctggatcttc tcaaaagcgt
      421 gtttttgagc actccccagg acctccctga aatcatcttg atactatctt tgatctgtac
      481 gattggagca tttttgaaca tgcatctgaa ggattttcca attcctcttc ctgtgatact
      541 atttttaatt ggatgctgtt ttgaaattct gagttttgca tctactcaga tccagttata
      601 tgcagatgcc atacagtgga tggatcctga catgtttttt gggatattta caccagtaat
      661 tatctttaat gttgcatttg acatggatat atacatgctt caaaagttat tttggcagat
      721 attattaatt acaattcctg gatttatgat taattacacc ttaatactgt ggtatctgca
      781 gtctgtgaat aaattatctt taaagaccat cccctggcta ctgttttcag ctgtgcttat
      841 cagttcagat cctatgctta cttcagcctc cataagagac cttggtcttt ccagaagcct
      901 cacaaattta attaacggag agagtctact gacctcagtg atatccttaa ttatatatag
      961 tgctgttgtg cagatcagtt tcaagtcaaa gcatatgaac cataccctag cccataaggt
     1021 catgtccaca gcttggtcat atcttgtgga aagtttcatc actggaatcc taattacaaa
     1081 agcgattcag ttatggatgg ctaccatctt tggtgatgac gtcaaccaca tcacgctcat
     1141 cttctcagtt ctatacctca tcttctatgt ttgtgagcta attggaatgt ctggaatatt
     1201 tactctggcc accataggac tttttctaaa ttctacaagt tttaaaccag gagttgaagc
     1261 atttctcctc gaattctgga actgcctgtc ctttattggt ttccttatgg tgttcacttt
     1321 cattggactt ctaatccctg cacacacata tttatatata tcattttctg atgtgtatta
     1381 ctcattaaat atctacttca cgctgattgt tttaaggctt ctggtctttc tgctaatgag
     1441 ccccattttg tctcgacttg gtcacgggtt cagctggcgc tgggcgttca tcatggtctg
     1501 gagtgaaatg aaaggaacac cgaacataaa tatggccctt ctgcttgcct actcggacgt
     1561 ttctcttggt tccgagaggg aaagatctca aatattattc catggcgtgt cagtatgtgt
     1621 aatcaccctg attgtcaata gatttatttt gccaatggca gtaattaaac taggtcttcg
     1681 tgatgtcaca tcaacaaaat ataaatcggt ttattataca ttccagcact ttcaagagct
     1741 aaccaaatcc acagccatgg cactcaaatt tgacaaagat cttgctaacg ctgactggaa
     1801 catggttgac aaggcgatta tacttcaaaa tccatatgct ttaaaccaag aagaaacaac
     1861 ggaacatcag aaggtgaaat gtcctgattg caacaaggaa atagatgaga cccttaacat
     1921 tgaagccatg gagttggcca acaggcgtct cctgtcagcg caaatagcaa gctaccaacg
     1981 acagtacagg aatgagattc tgtcccagag tgcaatgcaa gtgttggtag gcgcggccgg
     2041 aagctttggt gagaagaagg gagaatatat gagtcctgag aacataaaga attattcaga
     2101 aagcaaaaaa ctcctctcct ttcttagaaa attactactc aactgggtat ataatactaa
     2161 aaaagataaa ggggttccat caagatacat gtttcttcat gcatgccata gcatagtctt
     2221 cacaaatgaa tttgaataca ctggatacat cgctgtatta atgaacacat atccgatgat
     2281 aatctgttgg atttcccgac taaaagacat ctatcaatat gagataaaat gtgctaacta
     2341 ctattttctt acattttata ttctagaggc tctacttaag gtggcagcaa tgaggaagga
     2401 atttttttca cacacctggc tcctgtttga gctcgggatt accttggtcg gcatcctaga
     2461 tataatactt atcgaaacag actccattag ttacaaattt gacttaactg agactgtggt
     2521 cttcatgaac gtggttcgac tccttcgtat actgcgcatc ttgaagctta taacaccaaa
     2581 attgctgcaa gtaatagaca aaaggatgag ccagcagata tccttccggt atgctatact
     2641 aaaaggctac gtccaagggg aaatggatgt actgaatata attgatcaga ttgcaagttc
     2701 caaacaggct aaacagatat tgttaaagcg agtaataagg aatatggatc atgctatgaa
     2761 agagctgggc tacctagagt atgatcaccc agaaatcgct gtcactatga aaaccaagga
     2821 ggaggttaat gtgatgctca atatggccag agaaattgtc aaggctttca ggtccaaagg
     2881 aattatacat aaggtggaag gcgctgagat caacaagtta atcatggcca aaaagaaaca
     2941 agtgcttgag ctgcagtctg ttatccagcc acttaatgtt gaagaagccc catactatat
     3001 cccatggctc agtgaagatc ctgaagccat aagctttatt caggaaaaag caaaagttgt
     3061 gacatttgac tgcggaaata acatatttga ggaaggcgac gaaccagaag gaatctatgt
     3121 aataatttcg ggcatggtaa agcttaaaag gtcaaagcca cacctggaga tggatagagt
     3181 gtcctcagag tcagaggttg ctcagactag aagttataca ctgcctcaca cagaatatct
     3241 gctcagcggg gaaataatag gagagttaaa ctgtttgact aaagaacgga tgcaatattc
     3301 tgccacctgc aaaactgttg tggagacgta ttttattccc attagccact tgtatgaagg
     3361 ctttgaaaaa aaatacccta acatgaaata taaaatgtgg caaaaaatcg gacttgccat
     3421 tactgcccaa aagatccggg aaaacttatc ttttgaggac tggaactaca agatgcagtt
     3481 gaaactctgc aatgtcttcg taagggacat acccaagacc acaaaaactg acatctatga
     3541 tgaaacggta acccatgttg tcctcatcca tggatctgca gaagactgcc agttgcgaaa
     3601 aatttataag gcacctttcc taattcccgt gacatgccat cagatacaag gcttagaaga
     3661 gttcacaaaa gtcatgatta ttcaaacttc cgttgctgtg agaaaattca ggtggaatgt
     3721 aaaaaagtac aacccacctc gaaggatttc aatgaaacca gattctacag aatcacttga
     3781 aacattaaat gaaagttctg aagatgatga ggataaaaaa gagaatgaag aaaatgagga
     3841 atatttggaa gatattattg acatctcaag tgtctccaag aaataacctg gaaagaaagt
     3901 ttagtcagtc gcctgagctt ctcaccatgg caatgaaaac atatatttat ggagatagag
     3961 acaagccaaa gtttatatgc ctcttgtgtg ataatgtgaa ttaaagtacc ttgcactagt
     4021 caa
//
LOCUS       NM_001437704            3167 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus ETS transcription factor ERG (Erg), transcript
            variant 2, mRNA.
ACCESSION   NM_001437704 XM_006248142
VERSION     NM_001437704.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Manaud,G., Nossent,E.J., Lambert,M., Ghigna,M.R., Boet,A.,
            Vinhas,M.C., Ranchoux,B., Dumas,S.J., Courboulin,A., Girerd,B.,
            Soubrier,F., Bignard,J., Claude,O., Lecerf,F., Hautefort,A.,
            Florio,M., Sun,B., Nadaud,S., Verleden,S.E., Remy,S., Anegon,I.,
            Bogaard,H.J., Mercier,O., Fadel,E., Simonneau,G., Vonk
            Noordegraaf,A., Grunberg,K., Humbert,M., Montani,D., Dorfmuller,P.,
            Antigny,F. and Perros,F.
  TITLE     Comparison of Human and Experimental Pulmonary Veno-Occlusive
            Disease
  JOURNAL   Am J Respir Cell Mol Biol 63 (1), 118-131 (2020)
   PUBMED   32209028
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Wu,L., Zhao,J.C., Kim,J., Jin,H.J., Wang,C.Y. and Yu,J.
  TITLE     ERG is a critical regulator of Wnt/LEF1 signaling in prostate
            cancer
  JOURNAL   Cancer Res 73 (19), 6068-6079 (2013)
   PUBMED   23913826
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Birger,Y., Goldberg,L., Chlon,T.M., Goldenson,B., Muler,I.,
            Schiby,G., Jacob-Hirsch,J., Rechavi,G., Crispino,J.D. and
            Izraeli,S.
  TITLE     Perturbation of fetal hematopoiesis in a mouse model of Down
            syndrome's transient myeloproliferative disorder
  JOURNAL   Blood 122 (6), 988-998 (2013)
   PUBMED   23719302
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Nhili,R., Peixoto,P., Depauw,S., Flajollet,S., Dezitter,X.,
            Munde,M.M., Ismail,M.A., Kumar,A., Farahat,A.A., Stephens,C.E.,
            Duterque-Coquillaud,M., David Wilson,W., Boykin,D.W. and
            David-Cordonnier,M.H.
  TITLE     Targeting the DNA-binding activity of the human ERG transcription
            factor using new heterocyclic dithiophene diamidines
  JOURNAL   Nucleic Acids Res 41 (1), 125-138 (2013)
   PUBMED   23093599
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Vijayaraj,P., Le Bras,A., Mitchell,N., Kondo,M., Juliao,S.,
            Wasserman,M., Beeler,D., Spokes,K., Aird,W.C., Baldwin,H.S. and
            Oettgen,P.
  TITLE     Erg is a crucial regulator of endocardial-mesenchymal
            transformation during cardiac valve morphogenesis
  JOURNAL   Development 139 (21), 3973-3985 (2012)
   PUBMED   22932696
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   Yuan,L., Le Bras,A., Sacharidou,A., Itagaki,K., Zhan,Y., Kondo,M.,
            Carman,C.V., Davis,G.E., Aird,W.C. and Oettgen,P.
  TITLE     ETS-related gene (ERG) controls endothelial cell permeability via
            transcriptional regulation of the claudin 5 (CLDN5) gene
  JOURNAL   J Biol Chem 287 (9), 6582-6591 (2012)
   PUBMED   22235125
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Birdsey,G.M., Dryden,N.H., Amsellem,V., Gebhardt,F., Sahnan,K.,
            Haskard,D.O., Dejana,E., Mason,J.C. and Randi,A.M.
  TITLE     Transcription factor Erg regulates angiogenesis and endothelial
            apoptosis through VE-cadherin
  JOURNAL   Blood 111 (7), 3498-3506 (2008)
   PUBMED   18195090
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Jonson,L., Vikesaa,J., Krogh,A., Nielsen,L.K., Hansen,Tv.,
            Borup,R., Johnsen,A.H., Christiansen,J. and Nielsen,F.C.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248142.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.45363.1,
                                           SRR26643290.38967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000011.1  48251487-48251658   c
            173-390             JAXUCZ010000011.1  48198562-48198779   c
            391-542             JAXUCZ010000011.1  48179141-48179292   c
            543-746             JAXUCZ010000011.1  48168955-48169158   c
            747-827             JAXUCZ010000011.1  48168156-48168236   c
            828-899             JAXUCZ010000011.1  48166329-48166400   c
            900-968             JAXUCZ010000011.1  48158807-48158875   c
            969-1025            JAXUCZ010000011.1  48158140-48158196   c
            1026-1073           JAXUCZ010000011.1  48157502-48157549   c
            1074-3167           JAXUCZ010000011.1  48148149-48150242   c
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3167
                     /gene="Erg"
                     /note="ETS transcription factor ERG"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
     exon            1..172
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Erg"
                     /note="upstream in-frame stop codon"
     CDS             155..1594
                     /gene="Erg"
                     /note="isoform 2 is encoded by transcript variant 2; v-ets
                     erythroblastosis virus E26 oncogene like; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related;
                     transcriptional regulator ERG; v-ets erythroblastosis
                     virus E26 oncogene homolog; v-ets avian erythroblastosis
                     virus E26 oncogene; ERG, ETS transcription factor"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 2"
                     /protein_id="NP_001424633.1"
                     /db_xref="GeneID:170909"
                     /db_xref="RGD:621108"
                     /translation="MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQT
                     SKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGM
                     SYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLF
                     QNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRL
                     MHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSTWTGHSHPTPQSKAAQPS
                     PSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEG
                     TNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF
                     HGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPN
                     PYWNSPTGGIYPNTRLPASHMPSHLGTYY"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    497..748
                     /gene="Erg"
                     /note="SAM (Sterile alpha motif); Region: SAM_superfamily;
                     cl15755"
                     /db_xref="CDD:472832"
     misc_feature    1082..1333
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     misc_feature    1082..1333
                     /gene="Erg"
                     /note="erythroblast transformation specific domain;
                     Region: ETS; smart00413"
                     /db_xref="CDD:197710"
     exon            173..390
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            391..542
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            543..746
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            828..899
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            900..968
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1025
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1073
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..3167
                     /gene="Erg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatagaaacc tcttcctgcc attggctgac ttcatttccc agacttagca caatctcatc
       61 cgctctaaac aacctcatca aaactacttt ctggtcagag agaagcaata attattatta
      121 acatttatta acgatcaata aacttgattg cattatggcc agcactatta aggaggcctt
      181 gtcagttgtg agcgaggacc agtcactatt tgagtgtgcc tacggaacgc cacacctggc
      241 taagacagaa atgaccgcat cctcttccag tgactatggc cagacatcca agatgagtcc
      301 cagagtccca caacaggact ggctgtctca gcccccagcc agggtcacca tcaagatgga
      361 gtgcaaccct agccaggtga acggttccag gaactcacct gacgaatgca gtgtgaccaa
      421 aggtgggaag atggtgggca gccctgatac tgtgggaatg agctacggca gctacatgga
      481 ggagaagcac atgccgcccc ccaatatgac cacgaatgaa cgcagagtga tcgtccctgc
      541 agatcctact ctgtggagca cagaccatgt ccggcagtgg ctggagtggg cagtgaaaga
      601 atacggcctc ctagacgtgg acgtcttatt atttcagaat attgacggga aggagctgtg
      661 caagatgaca aaagatgact tccagaggct cactccgagc tacaatgccg acattcttct
      721 ctcacatctc cactacctca gagagactcc ccttccacat ctgacatccg acgacgttga
      781 taaggcttta caaaactctc cacggttaat gcatgctaga aacacagggg gtgcagcttt
      841 tattttcccc aatacttcag tatatcccga agccacgcag agaattacaa ctaggccaga
      901 tttaccttat gagcctccca ggagatcaac ctggaccggc cacagccacc ccacccctca
      961 gtccaaagct gcccagccat ctccctccac agtgcccaaa actgaagacc agcgtcctca
     1021 gttagatcct taccagatcc tgggacccac cagtagtcgc cttgctaatc caggtagtgg
     1081 ccagatccag ctgtggcagt tcctgctaga actcctgtct gacagctcca actccaactg
     1141 catcacctgg gaaggcacca acggggagtt caagatgaca gacccggatg aggtggctcg
     1201 gcgctggggg gagcggaaga gcaagcccaa catgaactat gacaaactca gccgtgccct
     1261 ccgctactac tacgacaaaa acatcatgac caaggtgcat gggaagcgct atgcctacaa
     1321 gtttgacttc cacgggattg cccaggccct gcagccccat ccccccgagt cgtccctgta
     1381 caagtacccc tccgacctgc cgtacatggg ctcctatcac acccaccccc agaagatgaa
     1441 ctttgtggct ccccaccctc cggccctccc agtcacatct tccagtttct ttgctacccc
     1501 gaacccatac tggaattcgc cgactggggg catctacccg aacactaggc tcccagccag
     1561 ccatatgccc tctcacctgg gcacctacta ctagagacca gatagaggcc tttcccaaca
     1621 gtgcacaatc gcctagcaat caccacaaac tcagagaaca caaatcgaaa gtgcctcctg
     1681 aggaatggaa acggttggcc agagctgggg aaggaagccg gggaaagaaa accaaagact
     1741 cacaggggag ggtgggcacc acccaagtat tactacagaa atagaagaag ctcaaaatat
     1801 actgtacatg gacatataac ctgtggtcca cccttgtcaa agacattgta tgtagaaaag
     1861 cgtgaccgag aagaacaact gtccaaggaa gtggccttaa gtagtgtaca aactgtagag
     1921 tgtgggacct tgcttgtacc aggattcagt gagagcaata gaaccataac agtcttggcc
     1981 tagcacacca tcacgtgtga tgacatttga agggaaacta cctgtgttta aaaacagaaa
     2041 aaaacatatc caaaccaaat aagaagagga aaaaaaaaaa aagatggcgg cccctccaca
     2101 gaccacaatg gctgtggatt ttcttggctg gcatttgctg ttttcattga aatcaggttc
     2161 gttccatttg atagggagct gccagctctg tcaaactgtg aagatgaccc agcgtctcat
     2221 caccttttca gtattacggg aaatgtgggc catgtggtgg gcggggaatg tatgtgcatg
     2281 ttgttgtgag tatgtgatca tagaagaaag actgaaacgg aggaagagat agaggatcag
     2341 gggttgggga gggagttaag ggagaggagg aagtggaaga ggaagaggag gagggaggag
     2401 gagaaagggg gaggaagaaa aggaggaaga ggagaaagga ggaggaagaa aaggagaaaa
     2461 tgaggaagag aaggaaaaga agaaaagaag ggggaggaag aggagaagga ggaagaggaa
     2521 gagaggaaga gaagcaagct gctcaagcca ccacagctga atttaggaca tcttgggacc
     2581 aaagagcatg agtcaagatg tttgatgctg ccagggttgt aagaaaggac acagatttgt
     2641 ggaggactgg gagcagtagt attcagaacc aaaaatatgt ctctttgtga aaaggaaatc
     2701 ataactggaa ttgtctgata tttaaaaaat tcaggacctc agtattcaat ggaggctttg
     2761 tccttcacag ggggcagttg agaggtgacc ttggtggcta ccatggtcag agaccacaca
     2821 ggcattgtgg gtaggtgggc tccagttttc cttaatgagt cgcgaacgct gtgcgttcgt
     2881 cagaacgaag tctacaagtc aatggttttt ttctttttat ataataatta tataacttat
     2941 gcatttatac actacgagtt gacctcggcc agccaaagac accacacaca cacacacaca
     3001 cacacacaca cacacacaca cacacacaaa agagacaatc aaacatatga tgtggccttg
     3061 aattttaact ctgtaatgct taatgtttac aatatgaagt tactagttct tagaatgcag
     3121 aatgtatgtt aataaaaatg agcttggcct ctcatggcga accagaa
//
LOCUS       NM_001109208            1771 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus BPI fold containing family B, member 3 (Bpifb3),
            transcript variant 1, mRNA.
ACCESSION   NM_001109208 XM_001063849 XM_575268
VERSION     NM_001109208.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Andrault,J.B., Gaillard,I., Giorgi,D. and Rouquier,S.
  TITLE     Expansion of the BPI family by duplication on human chromosome 20:
            characterization of the RY gene cluster in 20q11.21 encoding
            olfactory transporters/antimicrobial-like peptides
  JOURNAL   Genomics 82 (2), 172-184 (2003)
   PUBMED   12837268
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Dear,T.N., Boehm,T., Keverne,E.B. and Rabbitts,T.H.
  TITLE     Novel genes for potential ligand-binding proteins in subregions of
            the olfactory mucosa
  JOURNAL   EMBO J 10 (10), 2813-2819 (1991)
   PUBMED   1915264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474050.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575268.1, XM_001063849.1.
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1771
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI fold containing family B, member 3"
                     /db_xref="GeneID:499924"
                     /db_xref="RGD:1565613"
     exon            1..129
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    84..86
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="upstream in-frame stop codon"
     exon            130..255
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1520
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Potential ligand-binding protein RYA3; long
                     palate, lung and nasal epithelium carcinoma-associated
                     protein 3; Long palate, lung and nasal epithelium
                     carcinoma associated protein 3; antimicrobial peptide
                     RYA3"
                     /codon_start=1
                     /product="BPI fold-containing family B member 3 isoform 1
                     precursor"
                     /protein_id="NP_001102678.1"
                     /db_xref="GeneID:499924"
                     /db_xref="RGD:1565613"
                     /translation="MMPGVYALLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSL
                     VGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGLFSLVEELSGLKIEELTLPTV
                     SIKLLPGVGVQLSLHTKLAAEVNVSSKVALGMSPRGTPILILKRCNTLLGHISLTSGL
                     LPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVPLGPLGSVEFTLATL
                     PLISNQYIELDINPIVKSIAGDVIDFPKPRLPVKMPPKEDHTSQVTVPLYLFNTVFGL
                     LQTNGALDLDITPEMVPRNIPLTTTDLAALAPEALGKLPPGQHLLLSLRVMKSPMILL
                     QNKKVTVSIPVTIHVLSSVPQGTPVALFQMNGVMTLNAHLVPSTTKLHISLSLERLTV
                     QLASSFSQPFDASRLEEWLSDVVRAAYMQKLNEHLEVGIPLPKILNVNFANSVVDVIE
                     NAVVLTVAP"
     sig_peptide     141..200
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    216..845
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     misc_feature    216..845
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) domain; binds to and
                     neutralizes lipopolysaccharides from the outer membrane of
                     Gram-negative...; Region: BPI; cl00188"
                     /db_xref="CDD:412206"
     misc_feature    216..236
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI dimerizatation interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238164"
     misc_feature    216..236
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI dimerizatation interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:238164"
     misc_feature    order(231..233,246..248,255..257,267..269,276..278,
                     459..461,528..530,534..536,564..566,693..695,705..707,
                     717..719,816..818)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    order(231..233,246..248,255..257,267..269,276..278,
                     459..461,528..530,534..536,564..566,693..695,705..707,
                     717..719,816..818)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    915..1511
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP C-terminal domain; Region: BPI2;
                     smart00329"
                     /db_xref="CDD:128624"
     misc_feature    915..1511
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="BPI/LBP/CETP C-terminal domain; Region: BPI2;
                     smart00329"
                     /db_xref="CDD:128624"
     misc_feature    order(933..935,948..950,957..959,969..971,978..980,
                     1155..1157,1254..1256,1260..1262,1287..1289,1395..1397,
                     1407..1409,1419..1421,1497..1499)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     misc_feature    order(933..935,948..950,957..959,969..971,978..980,
                     1155..1157,1254..1256,1260..1262,1287..1289,1395..1397,
                     1407..1409,1419..1421,1497..1499)
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     exon            256..412
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            413..497
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..616
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..680
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..741
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..833
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1013
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1067
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1238
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1306
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1349
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1413
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1490
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1771
                     /gene="Bpifb3"
                     /gene_synonym="Lplunc3; Rya3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcccct ggctctcctt gcagaaggaa ggcttaattc aggccctcgg ggaaaaccgc
       61 aatttgctcc tgacttgaca tactgacggg tttctggcgg ctgtgccccc tttgtctctc
      121 caagctgctg tgtgcagctg atgatgccgg gtgtgtacgc cctgcttctg ctctggggcc
      181 tggccacgcc gtgtctgggg ctgcttgaga cagtgggcac gcttgctcgg attgacaaag
      241 atgagctggg caaagccatc cagaactccc tagttggggg tcccattctg caaaatgtgc
      301 tggggaccgt gacatcagtg aaccagggtc tcctgggcgc aggagggctg ctcggaggtg
      361 gtggactgct gagctacggt ggcctcttta gtcttgtgga ggaactctct gggttgaaga
      421 tagaggaact aaccttgccc accgtgtcaa tcaagctgct gccgggggtt ggggtgcagc
      481 tgagcctgca caccaagctg gccgcagagg tgaatgtgtc ttcgaaagtg gcactgggca
      541 tgagccctcg ggggacaccc atccttatcc ttaagcgctg caacacgctc ttgggccaca
      601 tcagcctgac gtcagggctg ctgcccacac caatctttgg gcttgtggaa cagacactgt
      661 gcaaggtgct gcctggactg ctgtgccctg tggtagacag tgtgctgagc gtggtgaatg
      721 agctcttagg agctacgctg agcctggtac cccttgggcc tctggggtct gtggagttca
      781 ctctggccac actgccccta atctccaacc agtacattga gttggatata aatcccatcg
      841 tgaagagcat agctggtgat gtcattgatt tccccaagcc acgcctccca gtcaagatgc
      901 cccccaaaga ggaccacacc tcccaagtga ctgtcccact ctacctcttc aacactgtgt
      961 ttgggctcct gcaaaccaat ggtgcccttg acctggacat cacccctgag atggttccca
     1021 gaaatatccc gctgacaact actgacctgg cagctttggc ccctgaggcc ctggggaagc
     1081 tgccccctgg tcagcacctc ctgctctcgc tgcgggtaat gaagtcaccc atgatcctgc
     1141 tgcagaacaa gaaggtcaca gtctctatcc cagtcaccat ccacgtgctg tcttctgtcc
     1201 ctcaaggaac tcctgtagct cttttccaga tgaatggagt catgactcta aatgcccacc
     1261 tggttccatc caccaccaag ctgcacatat ctctgtcctt ggaacggttg actgtccagc
     1321 tggcctcctc cttttcccaa ccttttgacg catcccgtct agaagaatgg ctcagtgatg
     1381 tggtccgggc tgcctacatg cagaagctca atgaacacct ggaggttgga atacctctgc
     1441 ctaaaatcct caacgtcaac tttgccaatt cagtagtgga tgtcattgag aatgcggtcg
     1501 tgctcacagt ggctccatga ggcagtatga ctgcagctct tcctgttcac taagagtcct
     1561 atctgtctgc ccgctctgcc tcagtttccc tcccagcatg cattggtggc agtataagta
     1621 ctcctctccc acccaggccc accttgccct ctgttcctgt gattatgact gtttggggat
     1681 ggggttgact ggacagccac agatctgctt cagaaagcac acagcacctt ggttcaggcc
     1741 cagcctcaat aaactgaccc ttggtcttgt g
//
LOCUS       NM_001135901             755 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus similar to human chromosome 20 open reading frame
            144 (C3h20orf144), transcript variant 1, mRNA.
ACCESSION   NM_001135901 XM_001062699 XM_575271
VERSION     NM_001135901.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001135901.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ080432.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000003.1  163514340-163514527
            189-241             JAXUCZ010000003.1  163514801-163514853
            242-755             JAXUCZ010000003.1  163515018-163515531
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..755
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="similar to human chromosome 20 open reading frame
                     144"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
     exon            1..188
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="upstream in-frame stop codon"
     CDS             59..652
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C20orf144 homolog"
                     /codon_start=1
                     /product="uncharacterized protein C20orf144 homolog
                     isoform 1"
                     /protein_id="NP_001129373.1"
                     /db_xref="GeneID:499927"
                     /db_xref="RGD:1561517"
                     /translation="MGNSGSHKRTKAPNQASKDRPPDMDKARHKQFFSHLKRKKPSVK
                     APDPARVGENPRIKAGKTKIVLLFPLDKRQQLAEAAAGPFVRPVRPAEDPLGAPTCFP
                     ATVAPMLRGAGDGVDRREGARAREMKRILVLLLQLDARLQEEGRRVAGRPGGGAKAQQ
                     YWQPLYAHLLTQREACGEGDPREEQPRKRRRCPRPRP"
     misc_feature    59..625
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     misc_feature    59..625
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /note="Putative Bcl-2 like protein of testis; Region:
                     Bclt; pfam15318"
                     /db_xref="CDD:434628"
     exon            189..241
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
     exon            242..755
                     /gene="C3h20orf144"
                     /gene_synonym="RGD1561517"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggctagagg gcagggctga ggcagcatgg gcagtggctt ctagtgacca gtcctatcat
       61 gggaaacagc ggttcccaca agaggaccaa agcacccaat caggccagca aggacaggcc
      121 acctgacatg gacaaggccc gtcacaagca gttcttcagc cacctcaagc ggaagaagcc
      181 aagtgtgaag gctcctgacc ctgcccgggt gggtgagaac ccccgcatca aggctgggaa
      241 aaccaagatc gtgctgcttt tcccgctgga caagcggcag cagctggccg aggcagcggc
      301 gggcccattt gtgcggcccg tgcggcccgc tgaggacccg ctcggcgccc cgacgtgctt
      361 cccagccacg gtggcgccta tgctacgtgg ggcaggcgac ggcgtggaca ggcgcgaagg
      421 tgcgcgcgcg agagagatga aaaggatcct ggtgctgctg ctgcagctgg acgcgaggct
      481 gcaggaggag gggcgtcgag tggcaggcag gccggggggc ggggccaagg cccagcagta
      541 ctggcagccg ctgtatgcgc acctgctgac ccaacgcgag gcctgcggcg aaggcgaccc
      601 ccgcgaggag cagccgcgca agcggcgccg ctgtcctcgc ccgcggccct gagtgtctgg
      661 cacgacccct aacgccagga ctctgctcaa taaagagcac atagcaaccc tggcgtctgc
      721 tacttctgtc cctgctgtcg gtcccagggt caaaa
//
LOCUS       NM_001437716           11086 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus golgin B1 (Golgb1), transcript variant 2, mRNA.
ACCESSION   NM_001437716 XM_006248379
VERSION     NM_001437716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11086)
  AUTHORS   Casey,C.A., Thomes,P., Manca,S. and Petrosyan,A.
  TITLE     Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver
            Cells
  JOURNAL   Biomolecules 8 (4), 150 (2018)
   PUBMED   30453527
  REMARK    GeneRIF: Ethanol-induced Golgi disassembly was associated with
            de-dimerization of the largest Golgi matrix protein giantin, along
            with impaired transport of selected hepatic proteins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11086)
  AUTHORS   Katayama,K., Kuriki,M., Kamiya,T., Tochigi,Y. and Suzuki,H.
  TITLE     Giantin is required for coordinated production of aggrecan, link
            protein and type XI collagen during chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 499 (3), 459-465 (2018)
   PUBMED   29577904
  REMARK    GeneRIF: giantin plays a pivotal role in coordinated production of
            aggrecan, link protein and type XI collagen in chondrocytes.
REFERENCE   3  (bases 1 to 11086)
  AUTHORS   Asante,D., Stevenson,N.L. and Stephens,D.J.
  TITLE     Subunit composition of the human cytoplasmic dynein-2 complex
  JOURNAL   J Cell Sci 127 (Pt 21), 4774-4787 (2014)
   PUBMED   25205765
REFERENCE   4  (bases 1 to 11086)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 11086)
  AUTHORS   Fusco,C., Micale,L., Egorov,M., Monti,M., D'Addetta,E.V.,
            Augello,B., Cozzolino,F., Calcagni,A., Fontana,A., Polishchuk,R.S.,
            Didelot,G., Reymond,A., Pucci,P. and Merla,G.
  TITLE     The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and
            promotes the sequestration and clearance of ubiquitinated proteins
            into the aggresome
  JOURNAL   PLoS One 7 (7), e40440 (2012)
   PUBMED   22792322
REFERENCE   6  (bases 1 to 11086)
  AUTHORS   Katayama,K., Sasaki,T., Goto,S., Ogasawara,K., Maru,H., Suzuki,K.
            and Suzuki,H.
  TITLE     Insertional mutation in the Golgb1 gene is associated with
            osteochondrodysplasia and systemic edema in the OCD rat
  JOURNAL   Bone 49 (5), 1027-1036 (2011)
   PUBMED   21851869
  REMARK    GeneRIF: concluded that mutation of the Golgb1 gene is responsible
            for the phenotypic characteristics including osteochondrodysplasia
            of ocd/ocd, and that giantin plays a pivotal role in multiple
            aspects of chondrogenesis
REFERENCE   7  (bases 1 to 11086)
  AUTHORS   Zhang,B., Zheng,C., Zhu,M., Tao,J., Vasievich,M.P., Baines,A.,
            Kim,J., Schekman,R., Kaufman,R.J. and Ginsburg,D.
  TITLE     Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
            accumulation of alpha1-antitrypsin
  JOURNAL   Blood 118 (12), 3384-3391 (2011)
   PUBMED   21795745
REFERENCE   8  (bases 1 to 11086)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 11086)
  AUTHORS   Breuza,L., Halbeisen,R., Jeno,P., Otte,S., Barlowe,C., Hong,W. and
            Hauri,H.P.
  TITLE     Proteomics of endoplasmic reticulum-Golgi intermediate compartment
            (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies
            ERGIC-32, a new cycling protein that interacts with human Erv46
  JOURNAL   J Biol Chem 279 (45), 47242-47253 (2004)
   PUBMED   15308636
REFERENCE   10 (bases 1 to 11086)
  AUTHORS   Diella,F., Levi,G. and Callahan,R.
  TITLE     Characterization of the INT6 mammary tumor gene product
  JOURNAL   DNA Cell Biol 16 (7), 839-847 (1997)
   PUBMED   9260927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248379.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000011.1  77405910-77406029   c
            121-272             JAXUCZ010000011.1  77395954-77396105   c
            273-367             JAXUCZ010000011.1  77394529-77394623   c
            368-520             JAXUCZ010000011.1  77393412-77393564   c
            521-670             JAXUCZ010000011.1  77393106-77393255   c
            671-799             JAXUCZ010000011.1  77391172-77391300   c
            800-925             JAXUCZ010000011.1  77388259-77388384   c
            926-1048            JAXUCZ010000011.1  77386320-77386442   c
            1049-1162           JAXUCZ010000011.1  77384776-77384889   c
            1163-1544           JAXUCZ010000011.1  77382442-77382823   c
            1545-1660           JAXUCZ010000011.1  77380722-77380837   c
            1661-1775           JAXUCZ010000011.1  77376673-77376787   c
            1776-1849           JAXUCZ010000011.1  77373742-77373815   c
            1850-6972           JAXUCZ010000011.1  77364402-77369524   c
            6973-8860           JAXUCZ010000011.1  77361629-77363516   c
            8861-9039           JAXUCZ010000011.1  77357257-77357435   c
            9040-9202           JAXUCZ010000011.1  77356198-77356360   c
            9203-9340           JAXUCZ010000011.1  77355886-77356023   c
            9341-9487           JAXUCZ010000011.1  77353582-77353728   c
            9488-9585           JAXUCZ010000011.1  77353246-77353343   c
            9586-9720           JAXUCZ010000011.1  77352612-77352746   c
            9721-9826           JAXUCZ010000011.1  77350034-77350139   c
            9827-11086          JAXUCZ010000011.1  77348569-77349828   c
FEATURES             Location/Qualifiers
     source          1..11086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..11086
                     /gene="Golgb1"
                     /note="golgin B1"
                     /db_xref="GeneID:192243"
                     /db_xref="RGD:708429"
     exon            1..120
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..272
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    272..274
                     /gene="Golgb1"
                     /note="upstream in-frame stop codon"
     exon            273..367
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..9961
                     /gene="Golgb1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Golgin subfamily B member 1; golgi autoantigen, golgin
                     subfamily b, macrogolgin 1; golgi-associated protein
                     GCP360; golgin B1, golgi integral membrane protein"
                     /codon_start=1
                     /product="golgin subfamily B member 1 isoform 2"
                     /protein_id="NP_001424645.1"
                     /db_xref="GeneID:192243"
                     /db_xref="RGD:708429"
                     /translation="MLSRLSGLANNVLHELSGDYTGWTTMTSSEAELPQGSAMELNNS
                     TQKDVLDRLADAEKLVLELKDIISKQDAQLQQKDEALQEEKKGAESKIKKIKLHAKAK
                     ITSLNKQIEELKTQGGAASPPEVQAEELSKHDKSSTEEEMEVEKIKHELQEKEKLISN
                     LQAQLDQAQSEQASQLDKSSAEMEDFVLMRQKLQEKEELIGALQTQLSQTQAEQAAQL
                     SSMQQVVREKDARFETQVRLHEDELLQLVTQSDVETEVQQKLRVMQRKLEEHEEALLG
                     RAQVVDLLQKELTSAEQRNQDLSQQLQLLEAEHSTLRNTMEAERQESKILMEKVELEM
                     AERKEELYQLQGQLERAGQAQAELEMQYGTLQQRHETEMEEKTACISLLQKNEQELQS
                     ACDALKEENSKLLQEQQEQAAKSAQALQQLEDELQQKSKEISQFVNKPNLEKHETSSQ
                     TSLPDVYNEGVQAVMEESVASLQKRVLELENEKGALLLSSLELEELRAENEKLCSRIT
                     LLEAQNRAGEADGMVCEVSTAGIALLNRSDSSTEESGQDVLENTFSQKHKELSVLLVE
                     MKEAQEEIAFLKSQLQGKRPEGDYEVLDRKEVQMMESEGLPSVTARDVLCAPRDKNSV
                     PAVEGEQAGMRDQHGTLEAGPLNDTGMELNSPQPDGVDKSLSAPHVCLCHQGELERLK
                     TQVLELETSLHTAKETHEKNLSEKAKEISSLTQLTKEFKESAEEARSTLTAVCEERDQ
                     LLYRVKELDVLGELRAQVRELETSLAEAEKQRGLDYESQRAQHNLLTEQIHSLSIEAK
                     SKDVKIETLQRELDGVQLQFSEQGTQIRSLQSQLQTKESEVLEGAERMKDISKEMEEL
                     SQALSQKELEIAQMDQLLLEKKKDVETLQQTIQEKDQQVTELSFSMTEKMVQLNEEKF
                     SLGVEIKTLKEQLSLLSRAEGAKKEQVEDSGAESSPKHGPHESSAQEPVCKDALQQEL
                     EWLRKESEQRKRKLQAALISRKELLQKVSKLEEELAKVREESTKDSLRESEKRELEED
                     SKNKDDPEKYGTSEWRELEVSLRLTISEKEVELEGIRRDLKEKAAAEEELQALVQRMT
                     QDLQNKTKQIDLLQEEITENQATIQKFITGTMDAGDGDSAVKETSVSSPPRAGGGEHW
                     KPELEGKIVDLEKEKTQLQKKLQEALISRKAILKKAQEKEKHLKEELKEQKDAYRHLQ
                     EQFDGQSKENENIAARLRQLQAKESTDQQLPGTGQQEPTHGSEGLSLEGTEPASESDL
                     HAAQPSHPGETATLQATVSVAQIQDQLKEIEVEKEELELKISSTTSELTKKSEEVLLL
                     QEQINEQGLEIQNLKAASHEAKAHTEQLKQELESSQLKIADLEHLKTLQPELETLQKH
                     VGQKEEEVSYLVGQLGEKEQTLTTVQTEMEEQERLIKALHTQLEMQAKEHEERLKQVQ
                     VEICELKKQPKELEEESKAKQQLQRKLQAALISRKEALKENKSLQEQLSSARDAVEHL
                     TKSLADVESQVSVQNQEKDALLGKLALLQEERDKLIVEMDKSLLENQSLGGSCESLKL
                     ALGGLTEDKEKLMKELESVRCSKIAESTEWQEKHKELQKEYEVLLQSYENVSNEAERI
                     QHVVESVRQEKQEVYAKLRSAESDKREREKQLQDAEQEMEEMKEKMRKFAKSKQQKIL
                     ELEEENDRLRAEAQPVGGANESMEALLSSNASLKEELERITLEYKTLSKEFEALMAEK
                     NTLSEETRNLKLQVEAQELKQASLETTEKSDEPKDVIEEVTEAVVGKSQEQDSLSENA
                     KLEDAEATLLANSAKPGVSETFSSHDDINNYLQQLDQLKGRIAELEMEKQKDRELSQT
                     LENEKNALLTQISAKDSELKLLEEEVAKINMLNQQIQEELSRVTKLKETAEEEKDDLE
                     ERLMNQLAELNGSIGNYYQDVTDAQIKNEQLESEMQNLKRCVSELEEEKQQLVKEKTK
                     VESEIRKEYMEKIQGAQKGPGSKIHAKELQELLKEKQQEVKQLQKDCIRYLGRISALE
                     KTVKALEFVHTESQKDLDATKGNLAQAVEHHKKAQAELSSFKILLDDTQSEAARVLAD
                     NLKLKKELQSNKESIKSQIKQKDEDLLRRLEQAEEKHRKEKKNMQEKLDALHREKAHV
                     EDTLAEIQVSLTRKDKDMKELQQSLDSTLAQLAAFTKSMSSLQDDRDRVIDEAKKWEQ
                     RFGDAIQTKEEEVRLKEENCTALKDQLRQMTIHMEELKITVSRLEHDKEIWESKAQTE
                     LQHQQKAYDKLQEENKELMSQLEEAGQLYHDSKNELTKLESELKSLKDQSTDLKNSLE
                     KCREHENNLEGIIKQQEADIQNCKFNCEQLETDLTASRELTTRLHDEINVKEQKIISL
                     LSGKEEAIQVAIAELHQQHSKEIKELENLLSQEEEENLTLEEENKRAVEKTNQLTEAL
                     ETIKKESLEQKAQLDSFVKSMSSLQDDRDRIVSDYRQLEERHLSVILEKDELIQDAAA
                     ENNKLKEEIRGLRGHMDDLNSENAKLDAELIQYRRDLNEVITIKDSQQRQLLEAQLQQ
                     NKELRNECVKLEGRLKGSEAEKQSLQMSLDALQEENQGLSKEIKSFKEQLTALHEEGA
                     LAVYHAQLRVREEEVQKLTAALSSSQKRTVDLQEELVCVQKEASKKVSEIEDKLKREL
                     KHLHHNAGIMRNETETAEERVAELARDLVEMEQKLLTVTKENKDLTAQIQAFGKSMSS
                     LQDSRDHATEELSDLKKKYDASLKELAQLKGRQDLGRESDVLSQAAFPLTTSENISSR
                     LEKLNQQLTSKDEQLLHLSSELESSHNQVQSFTKAMTSLQNERDHLWNELEKFRKSEE
                     GKQRSAAPSAASSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQMNQEITELRPL
                     KAQLQESQDQTKALQMMKEELRQENLSWQHELHQLRVEKNSWELHERRMKEQYLMAIS
                     DKDQQLGHLQNLLRELRSSSQTQILPTQYQRQASSGTSAALDGSQNLVYETDCLRTQL
                     NDSLKEIHQKELRIQQLNSKFSQLLEEKNILSTQLRDANQSLRDSQHHYSNLFNHCAI
                     LERQVQQLQATGPLNADVAPGAPQEKDGIHIKTETETTGEEQPSFSEVQQQLCNTKHD
                     LSELKKLLEEERDQRLTAENALSLAKEQIRRLEHSEWESARTPIIGACGSQEQVLLMD
                     LPGSSCRRTRSSAGWKRVLRSLCRSRTRVPLLAAIYFLMIHVLLVLCFTGHL"
     misc_feature    461..>817
                     /gene="Golgb1"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    461..>817
                     /gene="Golgb1"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    839..>3115
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    839..>3115
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2432..5143
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    2432..5143
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    4955..6373
                     /gene="Golgb1"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     misc_feature    4955..6373
                     /gene="Golgb1"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; Region: YhaN; COG4717"
                     /db_xref="CDD:443752"
     misc_feature    5900..8170
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    5900..8170
                     /gene="Golgb1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    7229..>9478
                     /gene="Golgb1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    7229..>9478
                     /gene="Golgb1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            368..520
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..670
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..799
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..925
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1048
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1162
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1544
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1660
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1775
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1849
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..6972
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6973..8860
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            8861..9039
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9040..9202
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9203..9340
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9341..9487
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9488..9585
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9586..9720
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9721..9826
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            9827..11086
                     /gene="Golgb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcgagtg gctgactccc aggggcgcgt cggtggtggc gctgcgcttg ggttacccga
       61 gctgacgtgg cttagattgg gcggggggcg tccggagttg tctgggacgg ccacctacag
      121 tgcttgaaga ggtcagaaaa ggacatcaga tcctctagga ctagagttac ggacggttgt
      181 gagcagccac gtggatactg agaggcgaac cctaggccct ctggaagagc agctggtgct
      241 cttaacctct gaccaactct gcagacccca ctagatgctg agccgattat cgggattagc
      301 aaataatgtt ttgcatgaat tatcaggaga ttacactggc tggactacaa tgacttcctc
      361 ggaagctgaa ttaccccagg gttctgccat ggaattgaat aatagtaccc aaaaggacgt
      421 tctggatcgc ctggctgatg cagagaagtt agtgctggag ctaaaggata tcatcagtaa
      481 gcaggatgct cagctccagc aaaaggacga agctctgcag gaagaaaaaa aaggagctga
      541 aagcaaaatt aaaaaaataa aacttcatgc aaaggccaag atcacgtcct tgaacaaaca
      601 aatagaagaa ttgaagacac aaggaggagc tgcctcgcct ccagaagtgc aggcagagga
      661 gctctccaag catgataaga gttcaacaga agaggagatg gaggtagaaa aaataaaaca
      721 tgaactccag gagaaggaga aattaattag caatttgcaa gcccagctgg accaggcgca
      781 gtcagaacaa gcctcccagt tggataagag ttctgcggag atggaggact tcgtcctgat
      841 gaggcagaag ctccaagaga aggaggaact catcggcgct ttgcaaacgc agctcagcca
      901 gacacaggca gagcaagctg cccagttgag ttccatgcag caggtggtcc gagagaaaga
      961 cgcccgcttt gagacacagg tccgtctcca cgaagatgaa ctccttcagt tagtaaccca
     1021 gtcagatgtg gaaacagagg tgcaacagaa attgagggtg atgcagagga agcttgagga
     1081 acacgaagaa gccttgctgg gccgagctca ggttgtggac ctgctacaga aggagctgac
     1141 ttctgcagaa cagaggaacc aggatctttc acagcagttg cagctgttgg aggctgaaca
     1201 cagtacttta aggaatacca tggaagcaga aagacaggag tccaagatcc tgatggaaaa
     1261 ggtagaactc gaaatggcag agaggaagga agagctgtat cagcttcagg gacagttgga
     1321 gcgagcaggc caagcccagg ctgagctgga gatgcagtac ggtactctcc agcaaagaca
     1381 tgagacagaa atggaggaga agacagcttg catttcgctt cttcagaaga acgagcagga
     1441 gctgcagtct gcctgtgacg ctctgaagga ggaaaactcc aagctgcttc aggagcagca
     1501 ggaacaggct gccaagtcag cccaggccct gcagcagctg gaagatgaac tccagcaaaa
     1561 atctaaagaa attagccaat ttgtaaacaa accaaacttg gaaaaacatg agacatcatc
     1621 tcagacgtct ttaccagatg tttataatga gggcgtacag gcagtcatgg aggagagtgt
     1681 cgcctcttta cagaagagag tactagagct agagaatgag aagggagcct tgctccttag
     1741 ttctctagag ctggaggagc tgagagctga gaacgaaaaa ctctgttctc ggattactct
     1801 tctggaggct cagaatagag caggagaggc tgatggtatg gtctgtgagg tcagcacagc
     1861 tggtattgct ttgctcaaca ggagcgactc ttctactgaa gaaagtggac aggatgtcct
     1921 agagaacaca ttttctcaga aacataaaga gctgtcggtt ttattagtgg aaatgaagga
     1981 agcccaggag gaaattgcat ttcttaagtc gcagctgcag ggcaaaaggc ctgaagggga
     2041 ctatgaggtc cttgatcgga aagaagtaca gatgatggag agtgaaggac tgccctcagt
     2101 tacagcacga gatgtcctct gtgcgccccg tgacaagaac agtgtcccag cagtggaagg
     2161 ggaacaggca ggcatgagag atcagcacgg aacattggag gcgggacctc taaatgacac
     2221 cggaatggaa ctgaactccc cacagccgga cggtgtggac aaatccctct ctgcaccaca
     2281 tgtctgtctg tgtcaccagg gtgaactgga aaggctgaaa actcaagttt tggagcttga
     2341 gacaagcctt catacagcca aggaaactca tgagaagaat ttaagtgaga aagcgaagga
     2401 aattagcagc ctaacccagc ttaccaagga gttcaaagag agtgcggagg aagcccgcag
     2461 cacgctcact gctgtgtgtg aagaaagaga ccagctgctt taccgggtga aggagcttga
     2521 tgtccttgga gaactccggg ctcaggtccg agaactggaa accagccttg cagaagcaga
     2581 gaagcaaaga ggtctggact atgaaagtca gagggctcag cacaacctgc tcaccgagca
     2641 gatccacagc ctaagcatag aagccaaatc taaagatgtg aaaatcgaga ctttacagag
     2701 agagctggat ggtgtgcaac tacaattttc tgaacaggga acacagataa gaagcctaca
     2761 gagccaactg cagacgaagg aaagtgaagt gctagagggg gcagagcgta tgaaggacat
     2821 ctcaaaagaa atggaagaac tgtcgcaggc gctttcacag aaggagctgg aaatagccca
     2881 aatggaccaa ctcttgttag agaaaaagaa agatgtggag acactccagc aaaccatcca
     2941 ggagaaggat cagcaagtga ctgaactcag cttcagtatg acagagaaaa tggttcagct
     3001 taatgaagag aagttttctc ttggggtaga aattaagact ctgaaggagc agctcagttt
     3061 attgtccaga gctgaaggag caaagaaaga gcaggtagaa gacagtggag ctgagtccag
     3121 ccctaaacat ggtccacatg agtcgagcgc acaggagcca gtgtgtaaag acgcactaca
     3181 gcaagaactt gagtggctga ggaaagagag tgagcagagg aagcggaaac tgcaggcagc
     3241 gctgatcagc agaaaggagc tactgcagaa agtcagcaag ctggaggagg agttagccaa
     3301 ggtgagagag gagtccacaa aagactccct cagggagagt gagaagagag agctggagga
     3361 agacagcaag aacaaagatg acccagaaaa gtatgggact tctgagtgga gggaactaga
     3421 ggtttcttta agactgacaa tatctgaaaa ggaagtggaa ctggagggca taaggaggga
     3481 cttaaaagaa aaggcagcag cagaagaaga gttacaggcc ttggtccaac ggatgactca
     3541 ggacctgcag aataagacaa agcagataga cttgcttcaa gaagagatca ctgaaaacca
     3601 agcaactatt cagaaattca tcacaggcac catggatgct ggggatggag actcagcagt
     3661 aaaggaaacc tcggtgagca gcccaccccg tgcagggggt ggggagcact ggaagccgga
     3721 gctggaggga aagatagtag acctggaaaa agaaaagact caacttcaaa agaagcttca
     3781 agaagcctta atttcccgta aggcaattct aaaaaaggca caagagaaag agaaacatct
     3841 gaaggaagag ctcaaggagc agaaggatgc ttaccgtcac ctacaggaac agtttgatgg
     3901 gcagagtaag gaaaatgaga acattgcggc ccgcctaagg caactccaag caaaggagtc
     3961 tacagaccag cagctcccag gcactggcca gcaggagccc actcacggtt cagaaggcct
     4021 ttcactcgaa ggcacagagc ctgcttcaga gtctgactta cacgcagctc agccttcgca
     4081 ccctggagag acagcaactc tccaggctac cgtttctgtt gcccagattc aggaccagct
     4141 gaaagaaatt gaggttgaga aagaagagct ggaattgaaa attagttcta caacaagtga
     4201 gctgaccaaa aaatctgaag aagtattact actacaagaa cagatcaatg aacagggctt
     4261 agaaatccag aatttgaagg cagcgtccca cgaagccaag gcccacacag aacagctgaa
     4321 gcaagaattg gaaagcagcc aattgaaaat tgctgacctg gaacatctga aaacattaca
     4381 gcctgaacta gaaacactgc aaaagcacgt gggccagaag gaagaagagg tcagctacct
     4441 tgttggacag cttggtgaga aggagcagac cctcaccacc gtacagacag aaatggagga
     4501 gcaggagcgt ttaatcaagg ccctgcacac acagctggaa atgcaagcca aggagcatga
     4561 ggagaggcta aagcaggtcc aggtggaaat ttgtgagcta aagaagcagc caaaagagct
     4621 tgaggaagaa agtaaggcaa aacagcaatt acagaggaaa ctgcaggctg ccctcatctc
     4681 ccggaaggag gccctcaagg aaaacaagag tctgcaggag cagttgtcct cggccagaga
     4741 tgctgttgaa cacctgacca aatctctggc agatgtagag agccaggttt ctgttcagaa
     4801 tcaagagaaa gatgcactcc taggaaagtt agcccttctt caggaagaaa gggacaaact
     4861 cattgtagaa atggacaagt ctttactgga aaatcagagc cttggtggct cttgtgaaag
     4921 cctgaagcta gctctcgggg gcctcactga agacaaggaa aagctgatga aggagctgga
     4981 atccgtgaga tgttctaaga ttgcagagag caccgaatgg caagagaagc acaaggagct
     5041 acagaaagag tatgaagttc ttctgcagtc ctacgagaat gtgagcaatg aggcagagag
     5101 gattcaacac gtggtggaga gcgtgaggca agagaagcag gaggtgtacg caaagttaag
     5161 gagcgcagag tcagacaaga gagagagaga gaagcagctg caggatgcag aacaggaaat
     5221 ggaggagatg aaggagaaga tgagaaagtt tgccaaatct aagcagcaga agatccttga
     5281 gctagaggaa gaaaacgacc gacttagagc agaggcccag cctgtaggag gagccaatga
     5341 aagcatggaa gctcttcttt cttccaatgc cagcttaaag gaggaactag aaaggatcac
     5401 attggagtat aaaacccttt ctaaggaatt tgaggcttta atggcagaga agaacactct
     5461 gagtgaagag actcgtaatc tgaagcttca ggtagaagct caggaactga aacaagctag
     5521 cctcgagacc accgagaagt ccgatgagcc aaaggatgtc atcgaagagg taacagaagc
     5581 cgtggtaggc aagtctcaag aacaagattc cctgagtgaa aatgccaagc ttgaagatgc
     5641 agaagctact ctcttggcta acagtgccaa gcctggtgtc agtgagactt tcagctcaca
     5701 cgatgacatc aataactacc tccagcagct tgatcagctt aaaggaagaa ttgctgagtt
     5761 agagatggag aaacagaaag acagggagct tagccagact ttggaaaatg aaaaaaatgc
     5821 cctactgact cagatatctg caaaggatag tgagctcaag ctcctggagg aagaggttgc
     5881 caaaataaac atgctgaatc agcaaatcca agaggagctc tccagagtca ccaagctgaa
     5941 agagacagca gaggaggaga aagatgactt agaagagagg ctgatgaatc aactggcgga
     6001 acttaatggg agcatcggga attattacca ggatgttaca gacgcccaaa taaagaacga
     6061 gcaactagag tcagaaatgc agaaccttaa aagatgtgtg agtgaattag aagaagaaaa
     6121 gcagcagctg gtcaaggaaa aaaccaaggt ggagtcagaa atacgaaaag agtacatgga
     6181 aaagatacaa ggtgcccaga agggacctgg cagtaaaatc cacgccaaag agctacagga
     6241 gctgctcaag gaaaaacagc aagaagtgaa gcaactgcag aaggactgca tccggtacct
     6301 cggcaggatc agtgccctgg agaagaccgt caaggccctc gagtttgttc acactgaatc
     6361 ccaaaaggat ttggatgcaa ccaaaggaaa tctggctcag gccgttgaac accacaagaa
     6421 ggcacaggcc gagttatcca gcttcaagat actgctagat gacacccaaa gcgaagcagc
     6481 aagagtgcta gcggacaacc tcaagttgaa aaaggagctt cagtcaaaca aagagtccat
     6541 caaaagccag ataaaacaaa aagacgaaga cctcttgcga agactggagc aagcagaaga
     6601 gaaacaccga aaagagaaga agaacatgca agagaagctg gatgctttgc acagagaaaa
     6661 agcccatgtg gaagacacgc ttgccgagat tcaagtcagt ctgaccagga aagacaagga
     6721 catgaaggag ctgcagcaaa gcctggacag caccttggcc cagcttgcgg ccttcactaa
     6781 gagcatgtcg tccctccagg atgaccggga cagggtgatc gatgaagcca agaaatggga
     6841 gcagaggttc ggtgatgcca ttcagaccaa agaggaggag gtcagactca aagaggagaa
     6901 ctgcactgct ctaaaggatc agctccgaca aatgaccatc cacatggagg aactgaagat
     6961 caccgtgtcc aggcttgaac atgacaagga aatttgggag tccaaggccc agaccgagct
     7021 ccagcatcaa cagaaggctt atgataagct gcaagaagaa aataaagaac ttatgtcaca
     7081 gttagaagaa gctggacagc tgtaccatga ttctaagaat gaattaacta agttggaatc
     7141 agaacttaag agtctcaaag accaatcaac tgacttaaag aactctttag aaaaatgcag
     7201 agaacacgaa aacaacttgg aagggatcat caagcagcaa gaagctgaca tccagaattg
     7261 taagttcaat tgtgaacaac tagagactga cctgacagcc tccagagagc taaccactcg
     7321 gctgcatgat gaaatcaatg tgaaggaaca gaagattata agcctgcttt ctggcaagga
     7381 agaggcgatc caagtagcta tcgcagaact gcaccaacag cacagtaaag agatcaaaga
     7441 attagaaaac ctgttgtccc aggaggaaga ggagaatttg accttagaag aggaaaacaa
     7501 aagggctgtt gagaaaacca accagctcac agaagcacta gaaaccatca agaaggagag
     7561 ccttgagcag aaggctcagt tggattcctt tgttaagtcc atgtcctctc ttcaggacga
     7621 ccgggaccgc atagtaagtg actaccgaca gctggaagag cggcaccttt ctgtgatctt
     7681 ggaaaaggac gagctcatcc aagatgctgc tgctgagaat aataaactga aggaggagat
     7741 tcgagggctg cgaggtcaca tggatgacct caactctgag aatgccaagc tggatgctga
     7801 actgatccag tataggcggg acctgaatga agtgatcacc ataaaggact cgcagcaaag
     7861 gcagctcctt gaggctcagc tgcagcagaa caaagagctg agaaatgagt gtgtaaagct
     7921 agaaggaagg ctgaaggggt cagaggcaga gaagcagagc ctgcagatgt ccttggacgc
     7981 cctccaggag gagaatcaag gtttgtctaa agagatcaaa agcttcaagg agcagttgac
     8041 ggccttgcac gaggaaggtg ccctagctgt ctaccatgcc caactgagag taagagagga
     8101 agaagttcag aagttaactg cggctctctc ctcctctcag aagagaactg tggatctgca
     8161 agaggagttg gtttgtgtcc agaaggaggc aagcaagaag gtgagtgaga ttgaagataa
     8221 gctgaagagg gagctgaagc atctccatca caacgcaggg ataatgcgga acgaaacaga
     8281 gacagcagaa gagagggtgg cagagctggc cagagacctc gtcgagatgg aacagaagtt
     8341 gcttacggta accaaagaga ataaggatct tacggcacag attcaggcct tcggaaagtc
     8401 gatgagttcc ttgcaggaca gcagagatca tgccactgag gagctgagtg acctgaagaa
     8461 gaagtatgat gccagtctga aagagctggc tcagctgaaa gggcggcagg acttaggcag
     8521 agagagtgac gttctttccc aggctgcctt tcccctgacc acctctgaaa acatctcgtc
     8581 ccgccttgag aaactgaacc agcagctcac atccaaagac gagcaattgc ttcacttatc
     8641 ttcagaacta gaaagttctc acaaccaagt gcagtccttc accaaggcca tgaccagcct
     8701 acagaatgag agagatcacc tgtggaatga gctggagaaa ttccggaagt cggaggaagg
     8761 gaagcagagg tctgcagccc cttcagctgc ctccagccca gcagaagtac agagcttgaa
     8821 aaaagccatg tcttcactcc agaatgacag agatcgattg ctgaaggaac tgaagaatct
     8881 acaacagcag tacttacaga tgaaccaaga gatcaccgag ctccgtccgc tgaaggctca
     8941 gcttcaggaa tctcaagatc agaccaaagc cctgcagatg atgaaggagg agctcaggca
     9001 ggaaaacctc tcctggcagc acgagctgca tcagctcaga gtggagaaga actcttggga
     9061 gctgcatgag agaagaatga aggaacagta ccttatggcc atctcagata aagatcagca
     9121 gcttggccac ctgcagaatc tcctgaggga actgaggtct tcctcccaga ctcagattct
     9181 ccccacacag taccagcgac aggcgtcctc agggacatca gctgccctcg acgggtcaca
     9241 aaacctagtt tatgaaacag actgtctcag gacccagctc aatgacagct taaaggaaat
     9301 ccatcagaag gagctaagaa ttcagcaact gaacagcaag ttctctcagc tgcttgagga
     9361 gaagaacatc ctctccaccc agctcaggga cgccaaccag agtctccgtg acagccagca
     9421 tcactacagt aacctcttca accactgtgc catcctggag aggcaggtgc agcagctgca
     9481 ggctacgggg ccactaaatg cagatgttgc tccaggagca ccccaggaaa aggatgggat
     9541 tcacataaag actgaaactg agaccacagg ggaggaacag ccaagctttt ctgaagtcca
     9601 gcagcagctg tgcaacacta aacacgatct gagcgagcta aagaagctgc tggaagaaga
     9661 gcgagaccaa agactgaccg ccgaaaatgc actctccctg gccaaggagc agatcagacg
     9721 gttggagcat agcgagtggg agtcagcccg gaccccaatc attggcgcct gtggctctca
     9781 ggagcaggtg ctgttgatgg atctcccagg cagtagctgt cggaggaccc ggagcagtgc
     9841 tggatggaag cgggttctgc gttctctctg ccgttcccgg acccgcgtgc cactgctcgc
     9901 agccatctac ttcctaatga ttcatgtttt actggttctg tgtttcacgg gtcacctata
     9961 aacttgttac ttgacaactc tcgcacttgt aattccttca tctgtagtgt caggattgtt
    10021 gatcccaggg cggcctctcg ctttgagccc accctcttgg aaagtgcctg tgaaaagagg
    10081 tggctgtgag gacaggcggc ggtaaggcct ggcctgccac atccgctctc cttaaacacg
    10141 tcggcttctg agatgtgccg tgttcactgc ttcttcagat gatgcagatc catatcccgt
    10201 gtggccttgc aggatgctga gagaggcttt ctagccgtgc caacaagatg gttccaataa
    10261 acacagtaat ctggaatcca gtatcgctct tcttagtaac ctgctttgtc ttgttgcctg
    10321 tattttctcc tgcctcggga tgaatgcaga gctgtgggca gtgagcacat tgccccatag
    10381 gacatgtgag cagtccttgg agcctcgggg gagccggaag gctcccgggc ttcagttgtt
    10441 ggatctcagg gaggaaggca ttttcttcct gcctgttcca tcgccagtgg ggggagggtg
    10501 tgttgctggg cattgtcagg actggacccc agcagctttg ccttcggtca catgtacact
    10561 aagatactaa gtggccggtc tttcctttcc aaaaggcagg aagaactggt gatggacagc
    10621 aaggctcaaa ctctatagtc ctattttctg gacgtgcctc cataggggtc ctgagatggt
    10681 gtccagaggc cagccgggcc atgccaaggt gaactggagt caggtctgag taccagtcac
    10741 accagcctca agaactacca agctgctgca ctgcttgtgc ggtgctggtt tattctgtct
    10801 ccagcgccac tgtcaccttc tgggaacagg ggctaaggtg gtgggaagag aaggcgaagc
    10861 acctgaatcc agacctgaag agcaatggct aggaatggat cccgctgtgt tggtcctccc
    10921 ctttacggac atgatgtgcc ccttcctgtt ctcaccccta aagaagagag agctgctggg
    10981 ctcactgatc aacccactgt tctgtgttga ttaaatttta ctcacaacat cccaaaaact
    11041 tccctcaact actgtaaaat aataaagtta ttttcagaat aaggaa
//
LOCUS       NM_001437762            2300 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 1, mRNA.
ACCESSION   NM_001437762 XM_006248395
VERSION     NM_001437762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248395.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO810735.1, SRR26360172.2291087.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000011.1  77465394-77465485   c
            93-162              JAXUCZ010000011.1  77464858-77464927   c
            163-274             JAXUCZ010000011.1  77462369-77462480   c
            275-437             JAXUCZ010000011.1  77461993-77462155   c
            438-567             JAXUCZ010000011.1  77456828-77456957   c
            568-661             JAXUCZ010000011.1  77452674-77452767   c
            662-761             JAXUCZ010000011.1  77449073-77449172   c
            762-940             JAXUCZ010000011.1  77444544-77444722   c
            941-1050            JAXUCZ010000011.1  77442290-77442399   c
            1051-1160           JAXUCZ010000011.1  77440692-77440801   c
            1161-1303           JAXUCZ010000011.1  77435682-77435824   c
            1304-1452           JAXUCZ010000011.1  77433449-77433597   c
            1453-1584           JAXUCZ010000011.1  77424393-77424524   c
            1585-1741           JAXUCZ010000011.1  77412154-77412310   c
            1742-2300           JAXUCZ010000011.1  77410986-77411544   c
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2300
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..92
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            93..162
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     exon            163..274
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1971
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 1"
                     /protein_id="NP_001424691.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWK
                     KLGEEPGDEMDVPKDELSIDLGTLFIGGTKPP"
     misc_feature    889..>1464
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    889..>1464
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    889..948
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    889..948
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    991..1020
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    991..1020
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    1042..>1122
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1042..>1122
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1054..1116
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1054..1116
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1141..1281
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1141..1281
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1348..1404
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1348..1404
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            275..437
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            438..567
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            568..661
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..761
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            762..940
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1050
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1160
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1303
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1452
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1584
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1741
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2300
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag gtacgctgtg cgggtcgggc
       61 cctgaggtgg acgaacgcgg ggaaaagatg agtgattcct ggaagcagtg aagggcacgg
      121 ccttgggatt cttgattcct caaaggtcag cctagcaaca gggtggtaga aaaaatgaag
      181 ccagcgggta cagacccaag gatcttgtct ttagctgctg aagtagcgaa aagtcctgaa
      241 caaaatgtcc ctgttatatt attgaagtta aaagaaataa taaacaacac ccctttggga
      301 agctcagagt taaagaaagt caagcaagat atatattgtt atgacctcat tcaatactgt
      361 ctattggtcc tcagtcaaga ttcttctcga atccagggtg gttggtctac aatttcccag
      421 ctgacacaga tactaagcca ttgctgtgtg ggattagagc caggagaaga tggagaagaa
      481 ttttacaagg aattacttcc atcagctgcc gaaaattttc ttgtcctggg aagacgattg
      541 caaacatgtt ttatcaatgc aactaagggt gaagagcaag ataaattact acattttttc
      601 caaattgtga ctgattctct cttctggcta ttgggaggtc atattcaact catacagaat
      661 gtactgcaga gtgatcattt cttgcaccta ctgcaaactg acaatgttca aataggagct
      721 acagtcatga ctctgcttca gaatatacta cagatcaaca gtggtaattt actcaaaata
      781 gaaggaaaag ccctgcattc tattttagat gaaattcttt tcaagctttt gtcaactcct
      841 agtccagtca taagaagtac tgctacaaag ctcctactgg tattggctga atcccatcag
      901 gaaattttga ttttactgag actaagtgcc tgctataaag gacttagaag tctgctaaat
      961 aaacaggaaa ctcttacaga atttagtcga gaacttagac agctcgttga tcttttaacc
     1021 cctaagatcc aacaggaagt agaagaacag aaactacata aagcagcttg cttgattcaa
     1081 gcctattgga aaggtttcca gaccagaaaa agattaaaga agcttccgtc tgctgtgatt
     1141 gccttgcaga ggagtttcag agctaaacga acaaagatgt tgttggagct aaataggcag
     1201 aaggaagaag aagacctcag attaagattg caacttcaaa aacagagagc catgaggctt
     1261 tcccgagagt cacgcttgag tatgcttgaa ataattcatc caggtcaagt ggagaaatac
     1321 aatagggaaa tagaagagaa atctgcattg actatccaga aacattggag agggtacagg
     1381 gaaaggaaga attttcgcca acagaggcca tctctcacag agtataaagc agctgtcaca
     1441 cttcagagag cagttcttaa attcctagca aagtgccgta agaaaaagaa actctttgcc
     1501 tcttggcatg gactccaaga actcactgat gcacgccgag ttgaactgaa gcaacaagtg
     1561 gatgactatg tcaaaagaca tccgggctct cagatgtcag atgtggccag cagagagctc
     1621 cacgcacaag cacaagaacg acttcaacac tattttatgg gaagagccat agaagagcga
     1681 gcccagcaac acagggaagc attgatggct cagatcagca ccaatattga gcagttgatg
     1741 aaggcaccaa gtctgaagga ggcggaagga aaggagcctg agcagttcct gagtagatct
     1801 aggcctgtgg cagccaaagc caagcaggcc caccttacca ccctgaagca catacaggcc
     1861 ccctggtgga agaagctcgg agaggaacca ggggatgaga tggatgttcc aaaggacgag
     1921 cttagtatag atttagggac tttatttatt ggtggaacca agcctcccta gagagttact
     1981 gggaaagccg gcattcttac cttttaagag attgttggtt ttgcctctgg catgcaggaa
     2041 gactaggtct atgccagtgg ctttccagag catcttcttc atgaacactt ggaagcaaag
     2101 agcagagcat tgcctacctc actctcagtt ctttccccat ctctacaccc tgtctgtagt
     2161 cacaaacaga tttgtgggct tttaattgtg ggacagaact caatgtgaaa ttttattgtt
     2221 aatttgaaat ttctttcatt ctgttttctg actaaaagtt gttttgtttt tgtttttaaa
     2281 taaatattgt ttctgaaaaa
//
LOCUS       NM_001106053            1134 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus golgin A6 family like 9 (Golga6l9), transcript
            variant 3, mRNA.
ACCESSION   NM_001106053 XM_001075379 XM_224432
VERSION     NM_001106053.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            CH473951.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075379.1, XM_224432.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC079439.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..1134
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="golgin A6 family like 9"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
     exon            1..61
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     exon            62..1134
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    118..120
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="upstream in-frame stop codon"
     CDS             172..996
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="spermatid associated like"
                     /codon_start=1
                     /product="uncharacterized protein LOC290425"
                     /protein_id="NP_001099523.1"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
                     /translation="MNISGSKQIHKRKILRLFSCFSCTQNQKKLKHKSQDVEKKLCRE
                     NKVLRDENRALRKDNKFLWGENKALGRENKTFRMDNQFIRERNHILRQQNQLLRKVKR
                     LISENPKLSGEECNALNTEGRSFWQQNRAMEAQITALRQQEKAFQNEAKALHEEIKSL
                     CEETKALQHQERALRMEEKALLRDGVAAELAEALTKEGAALEMEEQALWKEEQALREE
                     NKALREEHGALQDEEVALQEEARILQEWNNLLQGKITNNLPENMNNQDPEKCELRM"
     misc_feature    <313..>924
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <313..>924
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <637..>936
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
     misc_feature    <637..>936
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
ORIGIN      
        1 gcaatgtaag tctggctggt tgcctcaatc tttaaccctc ctagaacgct aagtaaatgc
       61 tcgggcctgt ctgagcattg tggtccatta agaagtcaac agacagccaa gactacatga
      121 acaaatttag tacattttct gttgagatta tcagtagtgc accgaaaaac aatgaatatc
      181 tctggatcaa aacaaataca caaaaggaaa atactgcggt tgttttcttg tttctcttgt
      241 acccaaaatc aaaagaaact caaacataaa tcccaggacg tggaaaaaaa actctgtaga
      301 gaaaataagg tgttgagaga tgaaaatagg gctctgagaa aagacaacaa atttctctgg
      361 ggcgaaaaca aagccttagg aagagaaaat aaaaccttcc ggatggacaa ccagttcatc
      421 agggaaagaa atcatatcct aaggcagcag aaccagctac tccggaaggt gaaaaggttg
      481 atttcagaga acccaaaact gtctggggaa gaatgcaatg ccttgaacac agaaggaagg
      541 tctttttggc aacagaatcg agccatggaa gctcagatca cagctctccg gcagcaagag
      601 aaagccttcc agaatgaggc caaagccttg catgaggaga tcaagtccct gtgtgaggag
      661 accaaggctc tacaacacca agagagggct ctcaggatgg aagagaaagc cctgctgagg
      721 gacggagtgg ctgcagagct ggcagaggcc ctgaccaagg agggagctgc tctagagatg
      781 gaagaacagg ctttgtggaa ggaagagcag gctctcaggg aggagaacaa ggcgctgaga
      841 gaagagcacg gggctctaca agacgaggaa gttgccctgc aggaagaggc gagaatcctc
      901 caggagtgga ataatcttct tcaggggaag atcacaaaca acctcccaga gaatatgaat
      961 aaccaagacc cagagaagtg cgaactaaga atgtaaccat gaagtcatga caataattgt
     1021 aattccagaa cataaaagta gaattcgatc gcgtaatgtt attgtcagaa gcctcagaaa
     1081 ttgacgtgct caatatttgg tccttgaaac aaaataaagg cctgagaaat aaat
//
LOCUS       NM_001437712            2500 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus COP9 signalosome subunit 7B (Cops7b), transcript
            variant 3, mRNA.
ACCESSION   NM_001437712 XM_039083916
VERSION     NM_001437712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 9, 2025 this sequence version replaced XM_039083916.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.32256.1,
                                           SRR26643295.36203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000009.1  94686294-94686475
            183-627             JAXUCZ010000009.1  94688336-94688780
            628-805             JAXUCZ010000009.1  94693686-94693863
            806-881             JAXUCZ010000009.1  94697608-94697683
            882-970             JAXUCZ010000009.1  94702271-94702359
            971-1173            JAXUCZ010000009.1  94705054-94705256
            1174-1279           JAXUCZ010000009.1  94706847-94706952
            1280-2500           JAXUCZ010000009.1  94710439-94711659
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2500
                     /gene="Cops7b"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
     exon            1..182
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            183..627
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    551..553
                     /gene="Cops7b"
                     /note="upstream in-frame stop codon"
     exon            628..805
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             644..1438
                     /gene="Cops7b"
                     /note="COP9 (constitutive photomorphogenic) homolog,
                     subunit 7b; COP9 constitutive photomorphogenic homolog
                     subunit 7B"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b"
                     /protein_id="NP_001424641.1"
                     /db_xref="GeneID:363273"
                     /db_xref="RGD:1306918"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFG
                     ELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSAAQQNKLKHLTIV
                     SLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGR
                     DIQKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKK
                     TLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH"
     misc_feature    905..1174
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    905..1174
                     /gene="Cops7b"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; Region: PINT; smart00088"
                     /db_xref="CDD:214509"
     misc_feature    1139..1288
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     misc_feature    1139..1288
                     /gene="Cops7b"
                     /note="COP9 signalosome complex subunit 7a helix I domain;
                     Region: CSN7a_helixI; pfam18392"
                     /db_xref="CDD:465740"
     exon            806..881
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            882..970
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1173
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1279
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..2500
                     /gene="Cops7b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttttaact taggctccaa tgtgccgagc agtgtgcgca tatgtggact ccttctatgg
       61 ggttggtttc tgaatcctgt tacttgaaac ccagcaggaa gatccacttt taccccggag
      121 acatgacagc ccaccgacag ttaacttctg tttacatgga actcaggagt ctgcaaatca
      181 tgtcattcta gataaatgtg atatttcatt aacgtatgtg tagtggctat tcctggttgt
      241 caacttgact gtatctggaa tgaactacaa tccagaattg gaaagctcac ctttgatcct
      301 gatcttgagg ttgggagata caagtttctg acctgaatct tggtatggag atcttgaggc
      361 aaagtgacca tgaatcccag gagcctaagg caaggagatc tctgagttca aggttatctg
      421 ggcaaagcaa gtcccagatc caggcatggt ggtacacacc tttaatctgg gacacaactt
      481 ctgctggaaa cctatataag gacattggaa gaaggaatag tctctttttt gcctgcctac
      541 cttgtgggac tgagccatcc tagatccttg gacttccatt cacagctgct gcttgctgat
      601 cattgttgga gagttggact acagactatc tcaagaccag agaatggcag gtgaacagaa
      661 accctcaagt aacctcttgg agcagtttat tttattagcc aaaggcacca gcggctcagc
      721 cctcaccact ctcataagcc aggtactgga ggctcctgga gtttatgttt ttggagaact
      781 actggagttg gccaatgttc aggagcttgc agaaggagct aatgctgcat atttgcagtt
      841 gctgaacctg tttgcctatg gtacataccc ggattacata gccaacaagg agagcctgcc
      901 agaactgagc gcagcccagc agaacaagct gaagcatctt accatcgtga gtttggcatc
      961 aagaatgaag tgtatcccct actctgtgct gctgaaggac ctggagatga ggaatctccg
     1021 ggaactagaa gaccttatca ttgaggctgt ctacactgac atcatccagg gcaagctgga
     1081 ccagcgaaac cagctcctgg aagtggattt ctgcattggc cgtgacatcc agaagaaaga
     1141 tatcaataat attgtcaaga ccttgcatga atggtgtgac ggctgtgagg cagttctcct
     1201 gggcattgag cagcaagttc tgagagccaa ccagtacaaa gagaaccacc accggactca
     1261 gcagcaggtg gaagccgagg ttagcaacat taagaagaca ctcaaagcaa cagcgtcctc
     1321 ctcagctcag gaaatggagc agcaactggc tgaacgggag tgtccccccc atactgagca
     1381 gaggcaaccc actaagaaga tgtccaaagt gaaaggtctg gtctccagcc gccactaggg
     1441 ccggctgggg cagctggcac tcagcaggcc tgggtcaggt gggaggggac acccagggcc
     1501 tatttcctcc cctctctaac tgcagtgagt tccagatctg cccgcccctc accagtacct
     1561 ccccatccat tggtaccatt tcggaaaatg attgctcctc ccttgcctcc tttcctagtt
     1621 gttcccttca gactcagggg ctcaacggat gccatcctaa cagggtccaa cactgcctgg
     1681 cttccctgca gggtccttgt ctctgtgatg ggctacctcc ctcccagttg ttcttttgcc
     1741 cctgtcattt tgtcaggctg gtcctaagct ggaggcagtt tccccagccc tgagggatga
     1801 ctgtggaggt ggctcctctc tgagtgaaga gggggccttg cttctccagc ctcgtgtacc
     1861 acagtaccca caatggtgca agtgtctcta gccaggtagc cacattgttt ccctctcctg
     1921 ccttacccct gttggcagtg ccagtgcagg ccatggaggg atgtggtgct gggctatgtt
     1981 tactaaacct ttgggttttc agcctcttaa gcccagccag gatctctcat cgagttgagg
     2041 cactaggctg actaacctct ggtgtctgat accagtgggg ggtgcttggg tctgtgggcg
     2101 gcagaaggcg tttctcctag cttggtgtcc tctgctgact gctcttcctg ctgcctctga
     2161 ctgctcagcc ttgatttggc atttaggctg cccactgccc actgggattg tctggcaaca
     2221 tttgctctcc caagatcttt catgcctcct ggctgcccct ggggtaggag tggtggtgcc
     2281 gaagcccctc agactggtga aggaccattg ctgcttcttt ctccttcctt cccacccctc
     2341 cttggctggc aacccagaac cctctgataa catcatactc cactcctggc cagagaaaag
     2401 gacttgacta gactttctga acttgaacag tttcaggtta tattttaatt tttttttgta
     2461 caggttgatt ctaatacatt tcaacatgct tttttctccc
//
LOCUS       NM_198200                699 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus pyroglutamylated RFamide peptide (Qrfp), mRNA.
ACCESSION   NM_198200 XM_063284298
VERSION     NM_198200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Schreiber,A.L., Arceneaux,K.P. 3rd, Malbrue,R.A., Mouton,A.J.,
            Chen,C.S., Bench,E.M., Braymer,H.D. and Primeaux,S.D.
  TITLE     The effects of high fat diet and estradiol on hypothalamic
            prepro-QRFP mRNA expression in female rats
  JOURNAL   Neuropeptides 58, 103-109 (2016)
   PUBMED   26823127
  REMARK    GeneRIF: Studies support a role for estradiol (E2) in the
            regulation of prepro-QRFP mRNA in the ventral medial nucleus of the
            hypothalamus/arcuate nucleus and suggest that E2's effects on food
            intake may be via a direct effect on the orexigenic peptide, QRFP.
REFERENCE   2  (bases 1 to 699)
  AUTHORS   Primeaux,S.D., Barnes,M.J. and Braymer,H.D.
  TITLE     Hypothalamic QRFP: regulation of food intake and fat selection
  JOURNAL   Horm Metab Res 45 (13), 967-974 (2013)
   PUBMED   23979792
  REMARK    GeneRIF: The present review discusses the role of QRFP in the
            regulation of feeding behavior, with emphasis on the intake of
            dietary fat.
REFERENCE   3  (bases 1 to 699)
  AUTHORS   Primeaux,S.D.
  TITLE     QRFP in female rats: effects on high fat food intake and
            hypothalamic gene expression across the estrous cycle
  JOURNAL   Peptides 32 (6), 1270-1275 (2011)
   PUBMED   21473894
  REMARK    GeneRIF: QRFP may play a role in coordinating feeding behaviors
            with reproductive function in rats when energy demand is increased.
REFERENCE   4  (bases 1 to 699)
  AUTHORS   Yamamoto,T., Miyazaki,R. and Yamada,T.
  TITLE     Intracerebroventricular administration of 26RFa produces an
            analgesic effect in the rat formalin test
  JOURNAL   Peptides 30 (9), 1683-1688 (2009)
   PUBMED   19520126
  REMARK    GeneRIF: Data suggest that the GPR103-26RFa system modulates
            nociceptive transmission in both the spinal cord and the
            supraspinal brain in the formalin (paw) test.
REFERENCE   5  (bases 1 to 699)
  AUTHORS   Beck,B. and Richy,S.
  TITLE     Suppression of QRFP 43 in the hypothalamic ventromedial nucleus of
            Long-Evans rats fed a high-fat diet
  JOURNAL   Biochem Biophys Res Commun 383 (1), 78-82 (2009)
   PUBMED   19341706
  REMARK    GeneRIF: QRFP 43 might play a role downstream of leptin in the
            regulation of feeding behavior.
REFERENCE   6  (bases 1 to 699)
  AUTHORS   Navarro,V.M., Fernandez-Fernandez,R., Nogueiras,R., Vigo,E.,
            Tovar,S., Chartrel,N., Le Marec,O., Leprince,J., Aguilar,E.,
            Pinilla,L., Dieguez,C., Vaudry,H. and Tena-Sempere,M.
  TITLE     Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as
            putative regulator of the gonadotropic axis
  JOURNAL   J Physiol 573 (Pt 1), 237-249 (2006)
   PUBMED   16543265
  REMARK    GeneRIF: potential role of the orexigenic peptide 26RFa in the
            control of the gonadotropic axis, thus suggesting its potential
            involvement in the joint control of energy balance and
            reproduction, especially in the female
REFERENCE   7  (bases 1 to 699)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
REFERENCE   8  (bases 1 to 699)
  AUTHORS   Chartrel,N., Bruzzone,F., Dujardin,C., Leprince,J., Tollemer,H.,
            Anouar,Y., Vallarino,M., Costentin,J. and Vaudry,H.
  TITLE     Identification of 26RFa from frog brain: a novel hypothalamic
            neuropeptide with orexigenic activity in mammals
  JOURNAL   Ann N Y Acad Sci 1040, 80-83 (2005)
   PUBMED   15891009
  REMARK    GeneRIF: Prepro-26RFa mRNA is expressed exclusively in two
            hypothalamic nuclei involved in the control of feeding behavior.
REFERENCE   9  (bases 1 to 699)
  AUTHORS   Chartrel,N., Dujardin,C., Anouar,Y., Leprince,J., Decker,A.,
            Clerens,S., Do-Rego,J.C., Vandesande,F., Llorens-Cortes,C.,
            Costentin,J., Beauvillain,J.C. and Vaudry,H.
  TITLE     Identification of 26RFa, a hypothalamic neuropeptide of the RFamide
            peptide family with orexigenic activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15247-15252 (2003)
   PUBMED   14657341
REFERENCE   10 (bases 1 to 699)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
  REMARK    GeneRIF: QRFP mRNA was highly expressed in the hypothalamus; QRFP
            receptor mRNA was highly expressed in the adrenal gland. Data
            suggests that QRFP and its receptor have a regulatory function in
            the rat adrenal gland.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Apr 9, 2025 this sequence version replaced
            XM_063284298.1, NM_198200.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1769568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680416, SAMN06680435
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000003.1  35487664-35487744   c
            82-699              JAXUCZ010000003.1  35485579-35486196   c
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..699
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="pyroglutamylated RFamide peptide"
                     /db_xref="GeneID:379044"
                     /db_xref="RGD:735020"
     exon            1..81
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /inference="alignment:Splign:2.1.0"
     exon            82..699
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..456
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="orexigenic neuropeptide QRFP; P518 precursor
                     protein"
                     /codon_start=1
                     /product="orexigenic neuropeptide QRFP precursor"
                     /protein_id="NP_937843.1"
                     /db_xref="GeneID:379044"
                     /db_xref="RGD:735020"
                     /translation="MRCLCSWLCLLLPLSACFPLLDRRGPTDIGDIGARMSWVQLTEG
                     HTPRSVQSPRPQALLVVAKEQQASRREHTGFRLGRQDSGSEATGFLPTDSEKASGPLG
                     TLAEELSSYSRRKGGFSFRFGR"
     sig_peptide     82..132
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    127..453
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="Orexigenic neuropeptide Qrfp/P518; Region:
                     RFamide_26RFa; pfam11109"
                     /db_xref="CDD:431659"
     misc_feature    127..453
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="Orexigenic neuropeptide Qrfp/P518; Region:
                     RFamide_26RFa; pfam11109"
                     /db_xref="CDD:431659"
     misc_feature    268..381
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="propagated from UniProtKB/Swiss-Prot (P83860.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    319..321
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000269|PubMed:16648250; propagated from
                     UniProtKB/Swiss-Prot (P83860.1);
                     pyrrolidone-carboxylic-acid site"
     misc_feature    445..447
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="Phenylalanine amide.
                     /evidence=ECO:0000269|PubMed:16648250; propagated from
                     UniProtKB/Swiss-Prot (P83860.1); amidation site"
ORIGIN      
        1 gccgattcgg gacctgagca gctctgcctg acattgggac ccagggactc gcctgccctt
       61 cttagagcgg cccacagcac aatgaggtgc ctctgctctt ggctttgcct cctcctgcct
      121 ctgagtgcct gctttcctct gctggacaga aggggaccca cagacatcgg tgacatcgga
      181 gccagaatga gctgggtcca gctgactgag ggacacaccc cccgctcagt tcaaagtcca
      241 cggccacagg ccctgctcgt ggtggccaag gagcagcagg cctctcgcag ggagcacact
      301 ggcttccgtc tagggaggca ggacagtggc agtgaagcca cggggttcct gcccactgac
      361 tcagagaagg ccagcggccc cctggggact ctggcagagg agctcagcag ctacagccgg
      421 cggaagggag gcttcagctt ccgcttcggc cggtgagggc ctgcgtggac tctgccctga
      481 ctgtccactc aagtctgggc cccaaccttg agagagaata tcacaatgaa tctggtggtg
      541 aataggtgtg tgtttgtttt tatttacaac tttgctaaag tgaaagacct gggtggtgtt
      601 aaaacaacaa caaaaaaaac ccaaaaaaaa caaaaaacaa aaaaaaccca gctggagatg
      661 gctcacaacc atctgaaata tacattaaat aaataaata
//
LOCUS       NM_001437718            2416 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 116 (Ccdc116),
            transcript variant 1, mRNA.
ACCESSION   NM_001437718 XM_017597901
VERSION     NM_001437718.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Wang,Y., Wu,W., Zhu,M., Wang,C., Shen,W., Cheng,Y., Geng,L., Li,Z.,
            Zhang,J., Dai,J., Ma,H., Chen,L., Hu,Z., Jin,G. and Shen,H.
  TITLE     Integrating expression-related SNPs into genome-wide gene- and
            pathway-based analyses identified novel lung cancer susceptibility
            genes
  JOURNAL   Int J Cancer 142 (8), 1602-1610 (2018)
   PUBMED   29193083
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_017597901.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.204626.1,
                                           SRR26643293.70232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000011.1  97349708-97349772
            66-203              JAXUCZ010000011.1  97350002-97350139
            204-752             JAXUCZ010000011.1  97351042-97351590
            753-1352            JAXUCZ010000011.1  97351695-97352294
            1353-2416           JAXUCZ010000011.1  97353770-97354833
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2416
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="coiled-coil domain containing 116"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
     exon            1..65
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..203
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    93..95
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="upstream in-frame stop codon"
     CDS             132..2225
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 116; stromal
                     cell-derived factor 2-like 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 116
                     isoform 1"
                     /protein_id="NP_001424647.1"
                     /db_xref="GeneID:287936"
                     /db_xref="RGD:1310080"
                     /translation="MARCRHHSGYLADDEAAHGTYVARLPKKHLLPEMRPTCKLGRVP
                     HLPSMNRYSERQGHQQNLRRPRAFGGFLDFLTEGQVLDSLQTVVEQATECVATMKTEA
                     GVPLVDVQDRVEVPNSRHRSRGRPSINTVHRHRARPTLCAGHPNNYPSCSSSMSDSHS
                     SVTAGWLGSRSQDSDLGARGVGSLPPMRDKLLLEKNLKRLLRLESKGKVLNQHCSQRD
                     SLLWDSLGSQSSSQPTREQPLSWFSGLLASTSVTPETSELGLGEQEMIFLKQELNKEI
                     KSLLNQPTSFNLPTYCPLREPHRTLDFLSEHHLFPALQRVVSQAVDKLSHACRHNGFP
                     LFPVTSELSPVFPGNSDLQPSSKASLPTDREARGETCYSPTSASSPKTSHRKSKDRRG
                     SPSNAVQMATRFRLKSPNKFLKKKALPSISSVSSLSYISNPWFEELTNFLVEQAVSLL
                     ICKYKFEESLNKQLGFISFPITEVLMDIFLGFKKVKGTHIRLSSDINWTCLLRKLEEA
                     EMARQALRHVSRSGTSPHSTSRIVTSHHSTGPSSRQPELTRDTDQDQSPESHLSLHPA
                     LPIRQVMGPRDSRIGQKQTANTNQSEARRSVISTAGMGSKTKEVVNIEEGKDTEEEEE
                     EEEEEDEEEEDEEEEDEEEDEEEDEEEEEEEERGSEEEETKDFSECEHAPSPPLHELE
                     NSVNETTIVSPGDSQ"
     misc_feature    183..1358
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    183..1358
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Domain of unknown function (DUF4702); Region:
                     DUF4702; pfam15774"
                     /db_xref="CDD:464862"
     misc_feature    1170..1331
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1308..1310
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V8B5.1); phosphorylation site"
     exon            204..752
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1352
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2416
                     /gene="Ccdc116"
                     /gene_synonym="Sdf2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgcggt agagctttaa agggtgctga atgagtgaac ccctagaagc acagcagaga
       61 ctctgaggag tctgcatctg tgctgtagga cctgaagaag gaagcagaaa acaaatttaa
      121 ttatccacat catggcaagg tgccgccacc actcaggtta tctggctgac gacgaggctg
      181 ctcacggcac ctatgtggct cggctgccca agaagcatct gttgccagag atgaggccaa
      241 cttgcaagct tgggcgtgta ccacacctac catcaatgaa ccgatactca gagcgccagg
      301 gccaccagca aaaccttagg cgccctcggg catttggtgg cttcctggat ttcctcacgg
      361 agggtcaggt actggacagc ttgcagacag tcgtggagca ggcaacagaa tgtgtggcta
      421 ccatgaagac agaggctgga gtgccactgg tggatgtaca agaccgagtg gaggtgccaa
      481 atagtaggca tcgttctcga ggcagaccca gcatcaacac tgtgcatcgg caccgtgctc
      541 ggcccacgct gtgtgctgga cacccaaaca attacccatc ttgctccagc tccatgtctg
      601 actcccatag cagcgtcaca gctggatggc tggggtcccg cagccaagac agtgacctgg
      661 gtgccagagg cgtaggctca ttgccaccca tgagggacaa actcctgctt gagaaaaacc
      721 tcaagaggct gctacgactg gaaagcaaag ggaaagttct gaatcaacac tgctcccaga
      781 gggattccct gctatgggac tcactgggca gccagagcag cagtcagccg acccgggaac
      841 agcccctgtc ttggttctct gggcttctgg cctccacttc agtcacccct gaaacttcag
      901 agttgggact cggagaacaa gagatgattt tcctcaaaca agaattaaac aaggagataa
      961 agtcactgct gaaccagcca acctccttca acctgcctac ctattgtcca ctcagggaac
     1021 cccatcgtac cctggatttc ctgtctgagc accacctctt tccagccctg cagcgtgtgg
     1081 tcagccaggc tgtagacaag ctgagccatg cctgccgcca caatggcttc cccctcttcc
     1141 ctgttacctc agagctgtct ccagtgtttc ctgggaactc cgatcttcaa cccagctcta
     1201 aggcttcctt acccaccgac agggaggcta ggggagagac ttgttattct cccacctcgg
     1261 cctccagccc taagacatct cacagaaaaa gcaaggacag aaggggctcc ccatctaatg
     1321 cagtccagat ggctaccaga ttcaggctca agagccccaa caagtttttg aagaagaagg
     1381 ccctgccctc catctcatcg gtgtccagct tatcctacat ctctaacccc tggtttgagg
     1441 aactcactaa cttcttggtt gagcaggcag tctccttgct tatctgcaag tacaagtttg
     1501 aggaaagcct caacaagcag cttggtttca tctcctttcc gatcactgag gttctcatgg
     1561 acatctttct gggcttcaag aaggtgaagg gtacccacat ccgcctatct tcagacatca
     1621 actggacctg tcttctgcgt aagttggagg aagcagagat ggcgcggcag gccctgagac
     1681 atgtctccag gtcaggaacc tctccacata gcacctcccg tattgtcacc tcccaccata
     1741 gcacaggacc ctcctctagg caaccagagc ttactcgtga cacagatcag gaccagtctc
     1801 cagagtccca cctctccctc caccctgcgt tgccaatccg ccaggtgatg ggtcctcggg
     1861 attctagaat aggccagaaa cagacagcaa acacaaacca gtcagaggcc agacgctctg
     1921 tgatttccac tgccggtatg ggctccaaga ccaaggaagt ggtgaacatt gaagagggta
     1981 aggacactga agaggaggag gaagaggaag aggaagagga tgaggaggaa gaggatgagg
     2041 aggaagagga tgaggaggag gatgaggagg aagatgagga agaggaggag gaggaggaga
     2101 gaggaagtga ggaggaagaa accaaggatt tttctgagtg tgagcacgct cctagcccgc
     2161 ctttgcatga attggagaac tctgtgaatg agaccactat agtgagcccc ggtgactccc
     2221 aatgagactt ctgtaagtca cgtggagtac tccagtcctt ttctcctctt gttctatcca
     2281 agtcgctggc cacccagcca gcccctgtcc taagtggggg tcaggataac tgggtgctca
     2341 ggaggagttc tgctaaagtt atcaagggag ccaaagagac aaatggaaat aaattacgtg
     2401 ttggtggaca ccgctg
//
LOCUS       NM_001437714            6447 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus Cbl proto-oncogene B (Cblb), transcript variant
            2, mRNA.
ACCESSION   NM_001437714 XM_006248258
VERSION     NM_001437714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6447)
  AUTHORS   Zhang,Z.Y., Bai,H.H., Guo,Z., Li,H.L., Diao,X.T., Zhang,T.Y.,
            Yao,L., Ma,J.J., Cao,Z., Li,Y.X., Bai,X., Chen,H.K., Suo,Z.W.,
            Yang,X. and Hu,X.D.
  TITLE     Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn
  JOURNAL   Sci Signal 13 (638) (2020)
   PUBMED   32606037
  REMARK    GeneRIF: Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6447)
  AUTHORS   Jeong,J.S., Kim,H.Y., Shin,B.S., Lee,A.R., Yoon,J.H., Hahm,T.S. and
            Lee,J.E.
  TITLE     Increased expression of the Cbl family of E3 ubiquitin ligases
            decreases Interleukin-2 production in a rat model of peripheral
            neuropathy
  JOURNAL   BMC Anesthesiol 18 (1), 87 (2018)
   PUBMED   30021515
  REMARK    GeneRIF: results suggest that ubiquitin and the E3 ubiquitin
            ligases c-Cbl and Cbl-b function as neuroimmune modulators in the
            subacute phase of neuropathic pain after nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6447)
  AUTHORS   Uchida,T., Sakashita,Y., Kitahata,K., Yamashita,Y., Tomida,C.,
            Kimori,Y., Komatsu,A., Hirasaka,K., Ohno,A., Nakao,R.,
            Higashitani,A., Higashibata,A., Ishioka,N., Shimazu,T.,
            Kobayashi,T., Okumura,Y., Choi,I., Oarada,M., Mills,E.M.,
            Teshima-Kondo,S., Takeda,S., Tanaka,E., Tanaka,K., Sokabe,M. and
            Nikawa,T.
  TITLE     Reactive oxygen species upregulate expression of muscle
            atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 314 (6), C721-C731 (2018)
   PUBMED   29513566
  REMARK    GeneRIF: Under microgravity conditions, elevated ROS may be a
            crucial mechanotransducer in skeletal muscle cells, regulating
            muscle mass through Cbl-b expression activated by the ERK-Egr
            signaling pathway.
REFERENCE   4  (bases 1 to 6447)
  AUTHORS   Li,P., Liu,H.L., Zhang,Z.Q., Lv,X.D., Chang,Y.X., Wang,H.J., Ma,J.,
            Ma,Z.Y., Qu,X.J. and Teng,Y.E.
  TITLE     Single nucleotide polymorphisms of casitas B-lineage lymphoma
            proto-oncogene-b predict outcomes of patients with advanced
            non-small cell lung cancer after first-line platinum based doublet
            chemotherapy
  JOURNAL   J Thorac Dis 10 (3), 1635-1647 (2018)
   PUBMED   29707316
REFERENCE   5  (bases 1 to 6447)
  AUTHORS   Li,P., Liu,H., Zhang,Z., Lv,X., Wang,H., Ma,J., Ma,Z., Qu,X. and
            Teng,Y.E.
  TITLE     Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma
            and Adenocarcinoma
  JOURNAL   Med Sci Monit 24, 623-635 (2018)
   PUBMED   29384143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6447)
  AUTHORS   Thirone,A.C., Carvalheira,J.B., Hirata,A.E., Velloso,L.A. and
            Saad,M.J.
  TITLE     Regulation of Cbl-associated protein/Cbl pathway in muscle and
            adipose tissues of two animal models of insulin resistance
  JOURNAL   Endocrinology 145 (1), 281-293 (2004)
   PUBMED   14525909
  REMARK    GeneRIF: CAP-Cbl pathway may have a role in the modulation of
            adiposity in fasting and in monosodium glutamate treated rats.
REFERENCE   7  (bases 1 to 6447)
  AUTHORS   Zhang,W., Shao,Y., Fang,D., Huang,J., Jeon,M.S. and Liu,Y.C.
  TITLE     Negative regulation of T cell antigen receptor-mediated Crk-L-C3G
            signaling and cell adhesion by Cbl-b
  JOURNAL   J Biol Chem 278 (26), 23978-23983 (2003)
   PUBMED   12697763
REFERENCE   8  (bases 1 to 6447)
  AUTHORS   Nishio,H., Otsuka,M., Kinoshita,S., Tokuoka,T., Nakajima,M.,
            Noda,Y., Fukuyama,Y. and Suzuki,K.
  TITLE     Phosphorylation of c-Cbl protooncogene product following ethanol
            administration in rat cerebellum: possible involvement of Fyn
            kinase
  JOURNAL   Brain Res 950 (1-2), 203-209 (2002)
   PUBMED   12231245
  REMARK    GeneRIF: c-Cbl protooncogene product is tyrosine- phosphorylated in
            rat cerebellum in response to ethanol administration.
REFERENCE   9  (bases 1 to 6447)
  AUTHORS   Yokoi,N., Komeda,K., Wang,H.Y., Yano,H., Kitada,K., Saitoh,Y.,
            Seino,Y., Yasuda,K., Serikawa,T. and Seino,S.
  TITLE     Cblb is a major susceptibility gene for rat type 1 diabetes
            mellitus
  JOURNAL   Nat Genet 31 (4), 391-394 (2002)
   PUBMED   12118252
  REMARK    GeneRIF: we report the positional cloning of Iddm/kdp1 and identify
            a nonsense mutation in Cblb, a member of the Cbl/Sli family of
            ubiquitin-protein ligases.Cblb is a major susceptibility gene for
            rat type 1 diabetes mellitus
REFERENCE   10 (bases 1 to 6447)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248258.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.47883.1,
                                           SRR26643429.41005.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000011.1  62225753-62225896   c
            145-330             JAXUCZ010000011.1  62224275-62224460   c
            331-581             JAXUCZ010000011.1  62210550-62210800   c
            582-728             JAXUCZ010000011.1  62149944-62150090   c
            729-885             JAXUCZ010000011.1  62132129-62132285   c
            886-1007            JAXUCZ010000011.1  62127140-62127261   c
            1008-1145           JAXUCZ010000011.1  62123379-62123516   c
            1146-1233           JAXUCZ010000011.1  62121947-62122034   c
            1234-1365           JAXUCZ010000011.1  62119699-62119830   c
            1366-1569           JAXUCZ010000011.1  62109937-62110140   c
            1570-1755           JAXUCZ010000011.1  62099325-62099510   c
            1756-2118           JAXUCZ010000011.1  62097450-62097812   c
            2119-2213           JAXUCZ010000011.1  62090404-62090498   c
            2214-2360           JAXUCZ010000011.1  62081938-62082084   c
            2361-2458           JAXUCZ010000011.1  62079026-62079123   c
            2459-2590           JAXUCZ010000011.1  62078778-62078909   c
            2591-2731           JAXUCZ010000011.1  62076111-62076251   c
            2732-2851           JAXUCZ010000011.1  62070742-62070861   c
            2852-6447           JAXUCZ010000011.1  62058829-62062424   c
FEATURES             Location/Qualifiers
     source          1..6447
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..6447
                     /gene="Cblb"
                     /note="Cbl proto-oncogene B"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
     exon            1..144
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            145..330
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3111
                     /gene="Cblb"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase CBL-B; SH3-binding protein CBL-B;
                     signal transduction protein CBL-B; casitas B-lineage
                     lymphoma proto-oncogene b; RING-type E3 ubiquitin
                     transferase CBL-B; Casitas B-lineage lymphoma b; Cas-Br-M
                     (murine) ecotropic retroviral transforming sequence b; Cbl
                     proto-oncogene B, E3 ubiquitin protein ligase; Cbl
                     proto-oncogene, E3 ubiquitin protein ligase B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-B isoform 2"
                     /protein_id="NP_001424643.1"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
                     /translation="MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRR
                     TVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLS
                     ENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAI
                     FPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKS
                     TIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY
                     STKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDG
                     RSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM
                     CTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLD
                     DDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVP
                     PRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPP
                     DSRLSRHFHHGEGVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSNL
                     NGRHSRMGSDQVLMRKHRRHDLPSEGAKVFSNGHLAPEEYDVPPRLSPPPPVTALLPS
                     IKCTGPIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHC
                     ILNGTHGTPSEMKKSNIPDLGIYLKGDVSDSASDPVPLPPARPPPRDNLKHGSSVNRT
                     PSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPS
                     DPFFDPASGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQAPARPPKPRPRRTA
                     PEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNLEVARSILREFAF
                     PPPVSPRLNL"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    283..663
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminal domain 1; Region:
                     Cbl_N; pfam02262"
                     /db_xref="CDD:426685"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    673..924
                     /gene="Cblb"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     Region: Cbl_N2; pfam02761"
                     /db_xref="CDD:460681"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    904..1194
                     /gene="Cblb"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; Region: SH2_Cbl-b_TKB; cd09920"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    order(958..960,1018..1020,1024..1035,1048..1050,
                     1084..1086,1090..1092)
                     /gene="Cblb"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198176"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    order(1093..1104,1141..1149)
                     /gene="Cblb"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198176"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    1213..1440
                     /gene="Cblb"
                     /note="RING finger, HC subclass, found in E3
                     ubiquitin-protein ligase Cbl-b and similar proteins;
                     Region: RING-HC_Cbl-b; cd16709"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    order(1246..1251,1258..1260,1330..1332,1387..1398)
                     /gene="Cblb"
                     /note="ubiquitin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438369"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    order(1258..1266,1282..1293,1348..1350,1357..1362,
                     1369..1371,1387..1392,1396..1398)
                     /gene="Cblb"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438369"
     misc_feature    2953..3075
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    2953..3075
                     /gene="Cblb"
                     /note="UBA domain found in E3 ubiquitin-protein ligase
                     Cbl-b and similar proteins; Region: UBA_Cbl-b; cd14392"
                     /db_xref="CDD:270575"
     misc_feature    order(2959..2964,2968..2976,2980..2985,2998..3000,
                     3010..3012)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     misc_feature    order(2959..2964,2968..2976,2980..2985,2998..3000,
                     3010..3012)
                     /gene="Cblb"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270575"
     exon            331..581
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            582..728
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..885
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1007
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1145
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1233
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1365
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1569
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1755
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2118
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2213
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2360
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2458
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2590
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2731
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2851
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..6447
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttagctc cgccccacgc cttggtctcc ggggatggct caggggtggg gtggccagtg
       61 agtggtctcc tcctccggcg ggcgctgcgg cggcctcccg agagtggcgc gggactgccg
      121 ggcgggcgtg gagctgtctg cacgaaagga ctaagattcc agatggcaaa ttctatgaat
      181 ggcagaaatc ctggtggtcg aggaggaaac ccccgcaaag gtcgaatttt ggggattatt
      241 gatgccattc aggatgcagt tggaccccca aagcaagctg cagctgaccg caggacagtg
      301 gagaagactt ggaaactcat ggacaaagtg gtaagactgt gccaaaatcc gaaacttcag
      361 ttgaaaaaca gcccaccata tatcctcgac attttacctg atacgtatca gcatttgcgg
      421 cttatattga gtaagtatga cgacaaccag aagctggctc aactgagcga gaatgagtac
      481 tttaaaatct acatcgacag tctcatgaag aagtcaaagc gagcgatccg gctcttcaaa
      541 gaaggcaagg agaggatgta cgaggagcag tcgcaggaca gacggaatct cacaaagctg
      601 tcccttatct tcagtcacat gctggcagaa atcaaggcga tctttcccaa tggccagttc
      661 cagggagata acttccggat caccaaagca gatgctgccg aattctggag gaagtttttt
      721 ggagacaaaa ctatcgtacc atggaaagtc ttcagacagt gcctgcatga ggtccatcag
      781 atcagctctg gcctggaggc catggctctg aagtcaacca ttgacttaac ttgtaatgat
      841 tacatctccg tgtttgaatt tgatattttt accaggctat ttcagccctg gggctctatt
      901 ttacggaatt ggaacttctt agctgtgaca cacccggggt acatggcatt tctcacatat
      961 gatgaagtta aagctcgact acagaaatac agcaccaagc ctggaagcta cattttccgg
     1021 ttaagctgca ctcggctggg acaatgggcc attggctatg tgactgggga cggcaatatc
     1081 ctacagacca tacctcataa taagcccctg ttccaagccc tgattgatgg tagcagggaa
     1141 ggcttttacc tttatccaga tggacgaagc tataaccctg atttaaccgg attatgtgaa
     1201 cctacacctc atgatcatat aaaagttaca caggagcaat atgaactgta ttgtgaaatg
     1261 ggctccactt ttcagctgtg caagatctgt gcagagaatg acaaagatgt caagatcgag
     1321 ccttgcgggc atctcatgtg cacttcgtgc cttaccgcgt ggcaggagtc tgatggccaa
     1381 ggctgcccct tctgtcgctg tgagataaaa ggaaccgaac ctatcatcgt ggatcccttt
     1441 gaccccagag acgaaggctc caggtgctgc agcatcatcg accctttcag catccccatg
     1501 ctcgacttgg atgatgacga tgatcgagag gagtctctga tgatgaaccg gctggcgagt
     1561 gttcgcaagt gcacagacag gcagaactcg ccagtcacat cgccaggatc ctcacccctt
     1621 gcccagagaa gaaagcctca gccagaccct ctccagatcc cccacctcag cctgccacca
     1681 gtgcctcccc gcctggacct cattcagaaa ggcatcgtgc gctctccctg tggcagcccc
     1741 acgggctccc cgaagtcttc tccatgcatg gttagaaaac aagacaaacc actcccagca
     1801 ccccctcctc ccttgcgaga tcctccgcct ccaccagagc ggcctccgcc aatcccgcct
     1861 gacagtagac tgagcagaca cttccaccac ggagagggtg tgccttccag ggaccagcca
     1921 atgcctcttg aagcctggtg ccctcgggat gccttcggga ctaatcaggt gatgggatgt
     1981 cgcatcctag gggatggctc tccaaagcct ggcgtcacag caaactccaa cttaaatgga
     2041 cgtcacagtc gaatgggctc tgaccaggtt cttatgagga aacacagacg ccacgatttg
     2101 ccttcagaag gcgccaaggt cttttccaat ggacaccttg cccctgaaga atacgacgtt
     2161 cctcctcggc tttcccctcc tcctccagtc actgcccttc tccctagcat aaagtgtact
     2221 ggtccaatag caaattgtct ctccgagaaa acaagagaca cagtagaaga agatgatgat
     2281 gaatacaaga ttccttcatc ccatcctgtt tccctgaatt cacaaccatc tcattgtcat
     2341 aatgtcaaac ctcctgttcg gtcttgtgat aatggtcact gtatactgaa tggaactcat
     2401 ggtacgcctt cagagatgaa gaaatcaaac atcccagatt taggcatcta tttgaaggga
     2461 gatgtttctg attcagcctc tgatccagta ccattaccac ctgccaggcc tccaccccgg
     2521 gacaacctaa agcatggttc ttcagtcaac aggacgccct ctgattatga tcttctcatc
     2581 cctccattag gtgaagatgc ttttgatgcc ctccccccat cccttcctcc tcctccacct
     2641 cctgcaagac atagtctcat cgagcattca aaacctccag gctccagtag ccggccttcc
     2701 tcaggacagg accttttcct tcttccttca gatccctttt ttgacccagc aagtggccaa
     2761 gttccattgc ctccggccag gagagcacca ggagatggtg tcaaatccaa cagagcctcc
     2821 caggactatg accagctccc ttcatcttcc gatggttcgc aagcaccagc tagacccccc
     2881 aaaccacgac cccgaaggac tgcaccagaa attcatcaca gaaagcccca tgggcccgag
     2941 gcggcactgg aaaatgtgga tgcgaaaatt gcaaaactca tgggagaggg gtatgccttt
     3001 gaagaggtga agagagcctt agagatcgcc cagaataacc tggaagtggc caggagcata
     3061 cttcgagaat tcgccttccc tcctcccgtc tcgccacgtc tcaatctata gcagcccaga
     3121 ctgcaaacac caaagggtaa aacagttaac aaatattcca ggagtatggg acggaaggac
     3181 tgagagggaa tgcaggagcc atggtgtctt ttcatgtggc gtctccagaa ggcagccttg
     3241 agtccagctt ctctggtacc acagctccct gaggatgccc acgctgcagc ttctgtgttt
     3301 gtgctagcca tacttttaaa tcagggttga actgagaaaa taatttaaag acgtttactc
     3361 ccccttgaac tttgaatctg tgaaatgctt tccttgttta cacgttggca gaattgcagt
     3421 ttgtctctgt ttttgattcc tgtactgtgt tcctgacagg cccttggcag agttggtcag
     3481 gtctgctgta agtttgtcca tgcccaccct gctgcccaca ttggcagcta aagcatctct
     3541 tcgtgttgct gtctatccgg gccccacctc atgtgtccac gtccagttca tttctctcat
     3601 tcacacagca tgctagtctg aggtcctgat ttttcatcgt tttaaactaa tgcagaaaga
     3661 aaaagaaaaa gaaaaaaaat gtatgtggtc tggtcttcac tactgagtct cttctttggg
     3721 aaccatcact gttgagaggt ggggaaacct gaatgtaaaa agcatttatt tgtcaataaa
     3781 ctgccttttg taaggggttt ttatatactg taaaagagct tcccttgtta gtttaagttc
     3841 tgtgaccttt aggtttctgt acactccctc ccgtccgccc aggagtgcca tgacagatgc
     3901 aggagaaaat ggggcagcgc ccgtactaca ggaccgtaat gagattctct gatagttatg
     3961 cctccatcac tttcaggaga gatggaaagg ggggccaccg cctcgaaata tgttaatatg
     4021 cctttagata aggtcataga catacatgcc tttcccaagt ggaagagagc cccttttcta
     4081 tgttatgaca tcaccctggc tcctccctgt gtgggagccc ctaaggcact gatgactgtt
     4141 atgtatcact gctactgcag gccttcttac ttgcaaaact cttcgtaccc tttctccagt
     4201 caggttagga gtcccgttta ctctgtgggt tttctcattg actgctccgt gttgcccgtc
     4261 ccagtcagat gaaaccgtgg tatcacttta aatctacaga taccccttga ccatctgtaa
     4321 agtgctttgc actcttgttg gctttgaaag cacaaaattt cacacatgaa ctccgccata
     4381 ttatttgtgt atatgtgttt ggtggtaaat gtctccaatc tgatggatga atcctctgag
     4441 actgatgcga ggacttttag accttcagat tgcttttgtt ttgttttgtt ttgttttgtt
     4501 ttgttttttg catccctaat agtgtgtgag gggaaataaa agccatctcc atgcaaaaat
     4561 gcttgcacga cattttgata gtttctaaag atggattcag ttgtaggttg catgggtgtc
     4621 tcttacccct ccttactcca cacccagaga tgcctcagat aatcactccc tcatcctgac
     4681 aaaggacaag atactacagc agatagatcc gatgcagctg ccattttatg agagtcatgt
     4741 ccacagctgt gtttgcccag aaaggggaac gtgcccagca tactcgtttg cagtgtggct
     4801 ttcatgggat gagacaggac ttgaggatca cagtctttgc atatgtcagg tttgttcaga
     4861 gggccctatg tttcttctgc taccacaggg ggatttttta atgtttttac atcctatacc
     4921 tgggaggagg tatgaataca aggttttttt ttaatatact ttttacaatt ggctctttgt
     4981 tgttttatta tctgctctta atttttttta cttgttttat aagttctgat gtcatactga
     5041 tagataacag tgctatgttt tttggggggt ttcacacaac ttgccaacaa tcggcatagc
     5101 ctaaaaccca aagtttgccc cttcgttgtc ctaacactgt taaacatcct taaactacga
     5161 gggggttggt ttacaacagg agcactggga cccacagcat attctcctgc actctcgcat
     5221 aacacaagag atttccgtca agaatttaaa ggctaaagat gtgctcaaac agttgatttg
     5281 gacctgaggt ttagggaggg agggaagtgt aaataatttt ctggattgta ccaagatctc
     5341 tgctgcatcc acacagtagc cactgccggt tttctcatca agaaaagtga accttgtgac
     5401 tcatacggaa gacagagcaa acagaaagca taaagactca cagaatttgt ttgagaacag
     5461 tagttcaaac tctttttcat taggaaaggg actactagtt aatactttga aatgtcccat
     5521 actttgttcc ctctttttcc agaaattgag atgtgcctcc caatgctcaa gatttgataa
     5581 tagaattacc cttaagccag tatttaatat aatctacaca attaaaacaa accacggcta
     5641 attggaacct ctgcccggga tctatcccca atgatattcc agtcgtggtt tttccagaat
     5701 tctggaggat ttttttccta tttccttttc cttttaaccc accacaccta cacccccacc
     5761 ccaacccata accccacatc cgaaccacca ccaacttctt ggtatctgat ctatcacagc
     5821 caaattttct ggacccagat cccaacattt tgatgcttaa cttaatcttg cacccacaat
     5881 taaaattatt agcccttttc taccttccct ctgcccacag tacaacacag agccctagcc
     5941 agagcctcca gaggtctgtt tgctaactca gtatttcgca cacccaagga cacatgcaaa
     6001 gagttcttca taatgtgaac tttctaattg ttcagttcca gaagcatttc ctgcagtttg
     6061 aacgtgactt tgcctctcgg attttcaact tgaagcttta gtttgcactg aattatttca
     6121 tctggtttta aaatgtctca aatggactga tttggaaaca aaatgtggta tattttaaat
     6181 attgatggag gtactttctg taaacctgaa atgttagagc tccgaggaag actttccgga
     6241 aaaagacagc aatagaaaga aagttttctt ctcagttcct atttttattg tttttgaaat
     6301 gcatttttta aaaacttgtc taatgtggca aaatagctat gtgatcaatt aatttatatt
     6361 ttattcattc tttttcaatt ctggatatgt aacctcaagt actttatctg ttcttttaag
     6421 gtattttata aaatgaatgt tgacaaa
//
LOCUS       NM_001106358            2394 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus doublesex and mab-3 related transcription factor
            3 (Dmrt3), transcript variant 1, mRNA.
ACCESSION   NM_001106358 XM_001078962 XM_219926
VERSION     NM_001106358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2394)
  AUTHORS   Andersson,L.S., Larhammar,M., Memic,F., Wootz,H., Schwochow,D.,
            Rubin,C.J., Patra,K., Arnason,T., Wellbring,L., Hjalm,G.,
            Imsland,F., Petersen,J.L., McCue,M.E., Mickelson,J.R., Cothran,G.,
            Ahituv,N., Roepstorff,L., Mikko,S., Vallstedt,A., Lindgren,G.,
            Andersson,L. and Kullander,K.
  TITLE     Mutations in DMRT3 affect locomotion in horses and spinal circuit
            function in mice
  JOURNAL   Nature 488 (7413), 642-646 (2012)
   PUBMED   22932389
REFERENCE   2  (bases 1 to 2394)
  AUTHORS   Konno,D., Iwashita,M., Satoh,Y., Momiyama,A., Abe,T., Kiyonari,H.
            and Matsuzaki,F.
  TITLE     The mammalian DM domain transcription factor Dmrta2 is required for
            early embryonic development of the cerebral cortex
  JOURNAL   PLoS One 7 (10), e46577 (2012)
   PUBMED   23056351
REFERENCE   3  (bases 1 to 2394)
  AUTHORS   Ahituv,N., Zhu,Y., Visel,A., Holt,A., Afzal,V., Pennacchio,L.A. and
            Rubin,E.M.
  TITLE     Deletion of ultraconserved elements yields viable mice
  JOURNAL   PLoS Biol 5 (9), e234 (2007)
   PUBMED   17803355
REFERENCE   4  (bases 1 to 2394)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219926.4, XM_001078962.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..2394
                     /gene="Dmrt3"
                     /note="doublesex and mab-3 related transcription factor 3"
                     /db_xref="GeneID:293976"
                     /db_xref="RGD:1306043"
     exon            1..721
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1683
                     /gene="Dmrt3"
                     /codon_start=1
                     /product="doublesex and mab-3 related transcription factor
                     3"
                     /protein_id="NP_001099828.1"
                     /db_xref="GeneID:293976"
                     /db_xref="RGD:1306043"
                     /translation="MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGH
                     KRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGD
                     AAATAATASQSSPASQASQPPAPPRPATELAAAAALRWVAEPQPGTLPAQIAKPDLTE
                     DRLGDSSSADNAAESFSDKDTDQRSSPDVVKSKNCFTPESPEIVSVDEGGYAVQKNGG
                     NPESCPDSPKYHAEQSHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELI
                     LKGCGGDLVSAVEVLLSSRSSAAGAERTAEESLVLPSSGHIFEHTLGSYPISSSKWSV
                     GSAFRVPDTLRFSADSSNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQSSPFLPND
                     VTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLSSRTTEDPRISIPDDGCPIVA
                     KQSIYTEDDYDERSDSSDSRILNTSS"
     misc_feature    325..465
                     /gene="Dmrt3"
                     /note="DM DNA binding domain; Region: DM; pfam00751"
                     /db_xref="CDD:459924"
     misc_feature    325..465
                     /gene="Dmrt3"
                     /note="DM DNA binding domain; Region: DM; pfam00751"
                     /db_xref="CDD:459924"
     misc_feature    517..642
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    691..837
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1009..1137
                     /gene="Dmrt3"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor 3 (DMRTA3); Region:
                     CUE_DMA_DMRTA3; cd14419"
                     /db_xref="CDD:270602"
     misc_feature    1009..1137
                     /gene="Dmrt3"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor 3 (DMRTA3); Region:
                     CUE_DMA_DMRTA3; cd14419"
                     /db_xref="CDD:270602"
     misc_feature    1504..1680
                     /gene="Dmrt3"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A218.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            722..2394
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcagacc gtaatcagag ctctcctcgg cccggtgcag ctgccctgag agcctcggcg
       61 tgggaggacc agcgggtgga gtttgctccg gggagagcgg cgagcagaga ggcggcgcgc
      121 gtggggaccc gcgggctgag agcaccatcg gagcggagga gactgcagcc gtacctccgg
      181 ctgctgccga ccttcccggg cctccgagct ccgcgctcca gctcccgccg tcgaccaggg
      241 ggagccctgg gcatgaacgg ctacggctcc ccctacctgt acatgggcgg cccggtgtcg
      301 cagccgccgc gggcgccctt gcagcggacg cccaagtgcg cgcgctgccg gaaccacggg
      361 gtgctatcct ggcttaaggg ccacaagcgc tactgtcgct tcaaggactg cacctgcgag
      421 aagtgcatcc tgatcatcga gcggcagcgg gtgatggcgg cgcaggtggc gctgcggcgg
      481 cagcaggcca acgagagcct ggagagcctc atcccggact cgctgcgggc tctgccaggg
      541 cctccgccgc cgggggacgc cgcggccacc gccgccaccg cctcgcagtc gtccccagcc
      601 tcccaggcgt cccagccgcc ggcgccgcct cgtcccgcca ccgagttggc cgcggccgct
      661 gcgctgcgct gggtcgccga gccccagccc gggacgctgc cagcgcagat tgctaagcca
      721 gatttgactg aagaccgact tggggacagc agttcagcag acaatgctgc ggagtccttc
      781 agtgacaaag acaccgacca gaggagctcc ccagatgtgg tcaaaagcaa gaactgcttc
      841 actccggaga gccccgagat cgtgtccgtg gatgaaggtg ggtacgccgt gcagaaaaac
      901 gggggcaacc cggagagctg ccctgacagc cccaagtacc acgctgagca gagccatctc
      961 ctgatcgagg gcccgtcagg gaccgtctct ctgcccttca gcttgaaagc caaccggcca
     1021 cccctggaag tgttgaagaa aatctttccc aaccagaagc ccactgtact ggagctcatc
     1081 ctgaaaggct gcgggggcga cctggtcagt gccgtggagg tcctgctgtc cagtcggtcc
     1141 tccgcggctg gggcggagcg gacggccgaa gagagcctgg tgctgccctc cagcggccat
     1201 atctttgaac acacgctggg ctcctaccct atctcttcct ccaagtggtc cgtgggctct
     1261 gccttccgag tccctgacac cttacgcttt tccgcggact ccagcaacgt ggtccccaac
     1321 cccttggccg tgcccctgca acatcctttc ccccagccac cccggtatcc gctgatgctg
     1381 aggaatactt tggccagaaa ccagtcgagc ccctttttgc ccaatgacgt caccctgtgg
     1441 aataccatga cactgcagca gcagtaccag ctgaggtccc agtatgtcag tccatttccc
     1501 agtaactcca ctagcgtctt ccggagctcg cccgtgctct cctctcgcac cacagaagac
     1561 cctcggatct ctatccccga cgatgggtgt ccaatcgtgg caaagcagtc catttacaca
     1621 gaggatgact atgatgagag gtccgactcc tcggattcta gaatactcaa cacgtcatcc
     1681 taaagtgtac ctgtgggtgg tgactgggtg acattttgtg tgtgctggac ctctcccccc
     1741 cgcccccgcc ccagggagag tccactaata ctgtatactc tttcttcctg tttgacaaag
     1801 tgactgtgct tggtagtctt atacattagc aataaaaaca taacttattt aatttcctgc
     1861 acttcactgg aaaatgccaa atagctctgc tctgtggatt tagtgctgaa tgttgtaaat
     1921 gagtttaaag ctgaggactg cctggggagg ccgggccagt gggggattta attgggggtg
     1981 ggggtcagct ttactcctaa gttcaacctg gaatgttccg tgaaatagta tacttgaatg
     2041 ccattttgta aaagaggatt cctcaggata ccggaaacct tagggagtgg ctctattgcc
     2101 agccgacaaa gagtagggac actcatgtta ctcccgttct aaagagagac tgcactcagg
     2161 ctagctcgga cggcacaggc tcatatttaa gctcggacag ttttcagaga caaactccat
     2221 taagaatcat tcttttcacg tggccgaatc gaaacatgtg taatgtcagt ataaagccaa
     2281 ccccagctgt gaactgcatg aaacgtgtcg ccgcggaaac gaacacaaga ttaagctttg
     2341 tcaggttaat gtagcatgct aagtaaggac tctagaaaaa taaactaagg acat
//
LOCUS       NM_001304424             398 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus sperm associated antigen 11b (Spag11b),
            transcript variant 2, mRNA.
ACCESSION   NM_001304424 NM_001037850 XM_002728419 XM_008773331
VERSION     NM_001304424.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Ribeiro,C.M., Queiroz,D.B., Patrao,M.T., Denadai-Souza,A.,
            Romano,R.M., Silva,E.J. and Avellar,M.C.
  TITLE     Dynamic changes in the spatio-temporal expression of the
            beta-defensin SPAG11C in the developing rat epididymis and its
            regulation by androgens
  JOURNAL   Mol Cell Endocrinol 404, 141-150 (2015)
   PUBMED   25657045
  REMARK    GeneRIF: Results from the spatio-temporal expression, cellular
            distribution showed that SPAG11C may play a role in epididymal
            development and/or sperm function.
REFERENCE   2  (bases 1 to 398)
  AUTHORS   Yenugu,S., Hamil,K.G., French,F.S. and Hall,S.H.
  TITLE     Antimicrobial actions of human and macaque sperm associated antigen
            (SPAG) 11 isoforms: influence of the N-terminal peptide
  JOURNAL   Mol Cell Biochem 284 (1-2), 25-37 (2006)
   PUBMED   16411022
REFERENCE   3  (bases 1 to 398)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before May 2, 2024 this sequence version replaced
            NM_001037850.1, NM_001304424.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.1005444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000016.1  77402473-77402553   c
            82-228              JAXUCZ010000016.1  77401807-77401953   c
            229-398             JAXUCZ010000016.1  77400550-77400719   c
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..398
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="sperm associated antigen 11b"
                     /db_xref="GeneID:100362580"
                     /db_xref="RGD:1562239"
     exon            1..81
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..362
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; sperm associated antigen 11C-like; sperm
                     associated antigen 11b-like"
                     /codon_start=1
                     /product="sperm associated antigen 11b-like isoform 2
                     precursor"
                     /protein_id="NP_001291353.2"
                     /db_xref="GeneID:100362580"
                     /db_xref="RGD:1562239"
                     /translation="MKRRLLPSFVSLLLAALLLPGSSSASSINHLVTEPPSSPQDEFP
                     AQGGNGSGLLHHRVKRFPPRTPPYHEPGPNYQIVNCKKNEGFCQKYCNFMETQVGYCS
                     KKKEACCLHPF"
     sig_peptide     21..95
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    33..236
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="Sperm antigen HE2; Region: Sperm_Ag_HE2; pfam05324"
                     /db_xref="CDD:461622"
     misc_feature    33..236
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /note="Sperm antigen HE2; Region: Sperm_Ag_HE2; pfam05324"
                     /db_xref="CDD:461622"
     exon            82..228
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
     exon            229..398
                     /gene="Spag11b"
                     /gene_synonym="Spag11; Spag11bl; Spag11c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagtcct ctccacagcc atgaaacgga gactccttcc ttcctttgtc agcctcctcc
       61 ttgcagccct gctccttcca gggtcgtcca gtgcctcgtc cattaaccac ttagtcactg
      121 aaccccccag ttccccccag gacgaatttc ctgcccaagg aggaaatggg tctgggttgt
      181 tgcatcacag agtgaaacgc ttccctccac gcaccccccc ttaccatgag cctggaccaa
      241 attaccaaat tgtcaactgc aagaaaaatg agggattctg tcaaaaatac tgtaatttta
      301 tggaaacaca agtgggctac tgttcaaaaa agaaagaagc ctgctgctta catcccttct
      361 gacggggctg atcactgaag ctgaagtgac ctgcacac
//
LOCUS       NM_001437787            2765 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RAB3A interacting protein (Rab3ip), transcript
            variant 4, mRNA.
ACCESSION   NM_001437787 XM_063263142
VERSION     NM_001437787.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Vetter,M., Stehle,R., Basquin,C. and Lorentzen,E.
  TITLE     Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3
            and Rabin8 effectors to Rab11
  JOURNAL   Nat Struct Mol Biol 22 (9), 695-702 (2015)
   PUBMED   26258637
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Klip,A., Sun,Y., Chiu,T.T. and Foley,K.P.
  TITLE     Signal transduction meets vesicle traffic: the software and
            hardware of GLUT4 translocation
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C879-C886 (2014)
   PUBMED   24598362
  REMARK    Review article
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Chiba,S., Amagai,Y., Homma,Y., Fukuda,M. and Mizuno,K.
  TITLE     NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by
            switching binding specificity from phosphatidylserine to Sec15
  JOURNAL   EMBO J 32 (6), 874-885 (2013)
   PUBMED   23435566
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Blumer,J., Rey,J., Dehmelt,L., Mazel,T., Wu,Y.W., Bastiaens,P.,
            Goody,R.S. and Itzen,A.
  TITLE     RabGEFs are a major determinant for specific Rab membrane targeting
  JOURNAL   J Cell Biol 200 (3), 287-300 (2013)
   PUBMED   23382462
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 9, 2025 this sequence version replaced XM_063263142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.9967.1,
                                           SRR26643292.29344.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000007.1  54448895-54449043   c
            150-429             JAXUCZ010000007.1  54446719-54446998   c
            430-688             JAXUCZ010000007.1  54444976-54445234   c
            689-784             JAXUCZ010000007.1  54436204-54436299   c
            785-862             JAXUCZ010000007.1  54428642-54428719   c
            863-1066            JAXUCZ010000007.1  54427855-54428058   c
            1067-1195           JAXUCZ010000007.1  54425796-54425924   c
            1196-1308           JAXUCZ010000007.1  54424518-54424630   c
            1309-1408           JAXUCZ010000007.1  54420776-54420875   c
            1409-1478           JAXUCZ010000007.1  54420625-54420694   c
            1479-2765           JAXUCZ010000007.1  54417418-54418704   c
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2765
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="RAB3A interacting protein"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
     exon            1..149
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..429
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="upstream in-frame stop codon"
     CDS             179..1561
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="isoform 1 is encoded by transcript variant 4;
                     rab-3A-interacting protein; rabin-3; SSX2-interacting
                     protein; rab3A-interacting protein"
                     /codon_start=1
                     /product="rab-3A-interacting protein isoform 1"
                     /protein_id="NP_001424716.1"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
                     /translation="MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPH
                     PSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGL
                     TRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYER
                     LKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATA
                     EKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNKSTSSA
                     MSGSHQDFSAIQPIVKDCREADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLT
                     FAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCKHRI
                     KLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSL
                     AKLGYFKEEL"
     misc_feature    467..>898
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    467..>898
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    617..619
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    623..625
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    695..901
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    695..901
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    914..1018
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62739.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    917..919
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    926..928
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    974..1552
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    974..1552
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    992..994
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    1016..1018
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    order(1229..1249,1412..1414,1421..1426,1433..1435,
                     1445..1447,1460..1474)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     misc_feature    order(1229..1249,1412..1414,1421..1426,1433..1435,
                     1445..1447,1460..1474)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     exon            430..688
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..784
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..862
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1066
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1195
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1308
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1408
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1478
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..2765
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagactggg ggcatcgggt cctagcggag atcatactcc tgcattttgc taagtgggac
       61 atgcagccag ctgcctccta aacgtgtgtt aatacccaga ggccagtgca gctcccagct
      121 gggccagagc aagaatagcg cagagactgc ttaggctgtc ctatgatgaa gtcttgctat
      181 ggctaacgac cccttagaag gtttccatga agtgaacctc gcttcgccta cctctccaga
      241 ccttcttggt gtgtgtgacc cgggaaccca agagcagact acctccccga gcgtcatcta
      301 ccggccacac ccttcgacgt tgtgctctgc cactatccag gccaatgcct taaatctttc
      361 tgaccttccc acacagcctg tgtattcatc cccgaggcat ttaaactgtg cagaaatatc
      421 taacatcagc attcatgttc cagagccagc atcatcggta gcctctgagg tggcagcagg
      481 gctcacgagg ttcacctcaa ggaaggacag ctgcaacgca gagagggagt ttctgcaggg
      541 cgccaccgtc acagaggctt ctgctggcaa cgatgacatc tttgggttga gcacggacag
      601 cctgtcccgt ttacggagcc catctgttct ggaagttaga gagaagggct acgaaaggtt
      661 aaaagaagaa cttgcaaaag ctcagaggga attgaagtta aaagatgaag aatgtgagag
      721 actttcgaaa gtgcgagatc aacttgggca ggagttggaa gaactcacag ctagtttatt
      781 tgaggaagct cacaagatgg tgagagaggc gaacgtcaag caggcaactg cagaaaagca
      841 gctgaaggaa gctcaaggga aaattgatgt gcttcaagcc gaagtggctg cgctgaagac
      901 actcgtactg tccagttctc caacatcgcc tacgcaggag cctctggcgg ctggaaagac
      961 gccctttaaa agggggcaca cacggaacaa aagtacaagc agtgctatga gtggcagcca
     1021 ccaggacttc agtgcgatcc agccaatcgt aaaagactgc agagaggccg atctatcgct
     1081 gtataatgag ttcaggtctt ggaaggatga gcccacaatg gacagaacat gtcccttcct
     1141 agacaaaatc tatcaggagg atatctttcc atgcttaaca ttcgcgaaaa gtgagttggc
     1201 ttcagctgtt ctggaggccg tggagaacaa cactctaagc atcgagccgg tagggttgca
     1261 gcccatccgc ttcgtgaagg cttccgcggt ggagtgcgga gggccaaaaa agtgtgctct
     1321 cactggccag agtaagccct gtaagcacag gattaaacta ggggactcca gcagctatta
     1381 ctacatctct ccggtttgca gataccggat cacttctgta tgtaactttt ttacatacat
     1441 tcgatatatt cagcagggac ttgtgaaaca gcaggatgtt gatcagatgt tctgggaagt
     1501 tatgcaacta agaaaggaga tgtcgttggc aaagctggga tatttcaaag aagaactctg
     1561 atgccctgag tacggggccg tgcgtgctcc tccctggaca gctgaaggat gacaacgttt
     1621 ttatggttac tcaatattta tttctaagga gaaggccaaa gacttccctc ctctgcacac
     1681 cacactatga agtgctgtga tttttttcaa actgactgag ctgtacttgc ttatccctta
     1741 atggaacaca ctctgaagat tgcaggcctg ctagtgatgg taattcaaca ctgcaaatcc
     1801 agaccaccaa ataaacacca gactgaacat gtgtgtcttt cttagctctg actcggcata
     1861 aagttgcaga ggttgatagt agtcttcaca ttgtacccct gtgagagcga ggaaggagcc
     1921 agctggacag ggcttcatgt ctgtgtgtat gctggcattc agacgaaagg ttttatttat
     1981 ttttattctg ccagctgtga tgtagggaat ccttttatca taatgatttg ttaagtgtaa
     2041 taaatgaaga cagtgaacat tcttgggcat cctgacggag ggcttcacgt tagcattgag
     2101 cattatcgtg gaatagaagg agtgttaagt ttaatagacc agggcatggc ctaaaaggat
     2161 acggtctgcc agctctgagc ttctggtgac tgcttcattt ctaaggttgg actaatgctg
     2221 acactcggga agaaacgacc aacatcagat gtacaaataa aagaggttcg tagtggagac
     2281 atagtatagg aaagcaaagg aaaacagccc gcttccttaa ctcgagtaag aacactccgc
     2341 tcacactttt ggagaacacc ttggactgtg aaatatttcc tacttataga tgcacaattc
     2401 tgattgttgt atgtgtgtga atgtgtgtgt gtgtgcatct cacttgggcc ttgtgcacac
     2461 agatctggaa ctggagttgc agacagccgt gagctgccgt ctctccagct tgtccctctc
     2521 gctttaaaag taaataattt ttctacattg tatgtgtcta tgagggtgta cctgtgtgtg
     2581 tgtggcagtc agatgacggc ttttaggagt ctgttctctc ctgtctaggt tttcatgatc
     2641 aaacagactc aggacatcag ggttggtagc aataccttta tgtgctgagc catttctctg
     2701 gtgcggatct ccacatccta atcattgtgt attcatcgca attaaacata gtctaattgt
     2761 ctcta
//
LOCUS       NM_001437733            1842 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus transmembrane inner ear (Tmie), transcript
            variant 1, mRNA.
ACCESSION   NM_001437733 XM_006243996
VERSION     NM_001437733.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Shin,M.J., Lee,J.H., Yu,D.H., Kim,H.J., Bae,K.B., Yuh,H.S.,
            Kim,M.O., Hyun,B.H., Lee,S., Park,R. and Ryoo,Z.Y.
  TITLE     Spatiotemporal expression of tmie in the inner ear of rats during
            postnatal development
  JOURNAL   Comp Med 60 (4), 288-294 (2010)
   PUBMED   20819378
  REMARK    GeneRIF: Tmie exists in the cytoplasm and may have a key role in
            the maturation and structure of stereocilia bundles in developing
            hair cells. After hair cell maturation, Tmie is thought to be
            involved in the maintenance of organ of Corti cells.
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Su,M.C., Yang,J.J., Chou,M.Y., Hsin,C.H., Su,C.C. and Li,S.Y.
  TITLE     Expression and localization of Tmie in adult rat cochlea
  JOURNAL   Histochem Cell Biol 130 (1), 119-126 (2008)
   PUBMED   18327602
  REMARK    GeneRIF: Our results point out the presence and localization of
            Tmie products in the cochlea of rat.
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Naz,S., Giguere,C.M., Kohrman,D.C., Mitchem,K.L., Riazuddin,S.,
            Morell,R.J., Ramesh,A., Srisailpathy,S., Deshmukh,D., Riazuddin,S.,
            Griffith,A.J., Friedman,T.B., Smith,R.J. and Wilcox,E.R.
  TITLE     Mutations in a novel gene, TMIE, are associated with hearing loss
            linked to the DFNB6 locus
  JOURNAL   Am J Hum Genet 71 (3), 632-636 (2002)
   PUBMED   12145746
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Mitchem,K.L., Hibbard,E., Beyer,L.A., Bosom,K., Dootz,G.A.,
            Dolan,D.F., Johnson,K.R., Raphael,Y. and Kohrman,D.C.
  TITLE     Mutation of the novel gene Tmie results in sensory cell defects in
            the inner ear of spinner, a mouse model of human hearing loss DFNB6
  JOURNAL   Hum Mol Genet 11 (16), 1887-1898 (2002)
   PUBMED   12140191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006243996.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.11848.1,
                                           SRR26643298.46929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               JAXUCZ010000008.1  119736002-119736330 c
            330-447             JAXUCZ010000008.1  119733032-119733149 c
            448-597             JAXUCZ010000008.1  119729876-119730025 c
            598-1842            JAXUCZ010000008.1  119728123-119729367 c
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1842
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="transmembrane inner ear"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
     exon            1..329
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    168..170
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="upstream in-frame stop codon"
     CDS             234..695
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /codon_start=1
                     /product="transmembrane inner ear expressed protein"
                     /protein_id="NP_001424662.1"
                     /db_xref="GeneID:501061"
                     /db_xref="RGD:1562523"
                     /translation="MAGRQRGSGRLWALGGAALGACLAGVASQLVEPSTAPPKPKPPP
                     LTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCRVPRTRKEIEARYLQRKAAKM
                     YTDKLETVPPLNELTEIPGEDKKKKKKDSVDTVAIKVEEDEKNEAKKKGEK"
     misc_feature    372..629
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="TMIE protein; Region: TMIE; pfam16038"
                     /db_xref="CDD:464987"
     misc_feature    372..629
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /note="TMIE protein; Region: TMIE; pfam16038"
                     /db_xref="CDD:464987"
     exon            330..447
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            448..597
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1842
                     /gene="Tmie"
                     /gene_synonym="RGD1562523"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccacacct accctcaccc cagtagtgat ggcgcaggtg gcgtcccggg aacctgacac
       61 ccaagatgaa taaatgatgc ggactcaacc gcccgcagcc agaactctcc gcggccgctg
      121 ccactaccac cgtcaccgcc tgccggtggc caggggcagt cacctggtag ctctgtgcat
      181 cagccccctc tgctctcagg acctgtagcg gagcccgcgg caaacaggag aacatggccg
      241 ggaggcagcg tggctcgggg cggctctggg cgctgggcgg cgccgcgctg ggggcttgcc
      301 tggcgggtgt cgcctcgcag ctggtagagc ccagcacggc cccgcccaag cccaagccgc
      361 ccccactgac caaggagacc gtggtgttct gggacatgcg cctgtggcat gtggtgggca
      421 tcttttccct cttcgtgctg tccatcatca tcacgctgtg ctgtgtgttc aactgccgtg
      481 taccgcggac acggaaggag atcgaggctc ggtatctaca gcgaaaagca gccaagatgt
      541 acacagacaa gctggagacc gtgcctcccc tcaacgaact cacagaaatc cctggagagg
      601 acaagaagaa aaagaagaag gacagtgtgg acaccgtggc tatcaaggta gaggaggacg
      661 agaagaatga ggcaaagaag aaaggagaga agtgagggcg gcgtcctgga gatggcagcc
      721 ggggctggca ggccctgaag cgtaagttca ggccgggatc caggcatcaa gactccgagt
      781 tcatacatgg acggcagagg ctgtggtcca agggaaagcc aaggtcgtgg gcattacctc
      841 acggcccaaa agatgtaggg acaagactgg actctgttca tttcacatgg tcagtctggg
      901 cacttctcac gggccactgt ccctctatag atatagagtg gcctcaaact cctctcccca
      961 tccaggcaag cttctgtccc acccttcttg ccaggggcag aagtggctat gaaggagtca
     1021 gggattggtc gatgaggatg gcaggattga acagattgtt caacaacaca gatggaggac
     1081 tggaagggga cttgtgacat gggagattct ctgacatagc tagatagcca ccccaaagag
     1141 caaggagatt gccccaagtt tgacggtgat ctgtccttgg cttctagggt gtccccatta
     1201 tcaggagaat ccctgatctg gcaaatgcca agctctgaaa acaaggtaac agcgtgacag
     1261 ggcggagacc actgaggggc tggcaggagg cctagggcct aagggcttct ggctcagggg
     1321 tggggtctga aacatagaag aatgagttgc gtgggccgag tgagaaaacc tgggtctcct
     1381 cacgggaacc aagaactact caagacgcag tgcatggggt acggactact gcggttgcct
     1441 tttctctggc caggactctg tcagaccacc agtctgccga acacagtggt atgcaggtcc
     1501 tcttctgcca tgtcccttac tttaaaaagc atctctgcca agaagacgaa tgaaacgcca
     1561 tggaggggct ggctccggag aggggagatg tacgaaggca cttctagcgt caaaatgagg
     1621 agctgtgccc ggagctgggg actgagaccc tggaagactt tcccagtgtg aagcctgcta
     1681 gaaaggtgtc ctgaggaaat ctataactaa agctgggtgc cttctcagcc ccaggcatat
     1741 aaaacttcac cctgagatga acttccaccc cggtcccacg ctttgcctgg tccttaagga
     1801 ttcctgtaaa agtgacacaa catgataggt gcctcagaca aa
//
LOCUS       NM_001437786            2775 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus RAB3A interacting protein (Rab3ip), transcript
            variant 3, mRNA.
ACCESSION   NM_001437786 XM_006241360
VERSION     NM_001437786.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Vetter,M., Stehle,R., Basquin,C. and Lorentzen,E.
  TITLE     Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3
            and Rabin8 effectors to Rab11
  JOURNAL   Nat Struct Mol Biol 22 (9), 695-702 (2015)
   PUBMED   26258637
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Klip,A., Sun,Y., Chiu,T.T. and Foley,K.P.
  TITLE     Signal transduction meets vesicle traffic: the software and
            hardware of GLUT4 translocation
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C879-C886 (2014)
   PUBMED   24598362
  REMARK    Review article
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Chiba,S., Amagai,Y., Homma,Y., Fukuda,M. and Mizuno,K.
  TITLE     NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by
            switching binding specificity from phosphatidylserine to Sec15
  JOURNAL   EMBO J 32 (6), 874-885 (2013)
   PUBMED   23435566
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Blumer,J., Rey,J., Dehmelt,L., Mazel,T., Wu,Y.W., Bastiaens,P.,
            Goody,R.S. and Itzen,A.
  TITLE     RabGEFs are a major determinant for specific Rab membrane targeting
  JOURNAL   J Cell Biol 200 (3), 287-300 (2013)
   PUBMED   23382462
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006241360.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.30691.1,
                                           SRR26643291.20287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000007.1  54461114-54461277   c
            165-439             JAXUCZ010000007.1  54446719-54446993   c
            440-698             JAXUCZ010000007.1  54444976-54445234   c
            699-794             JAXUCZ010000007.1  54436204-54436299   c
            795-872             JAXUCZ010000007.1  54428642-54428719   c
            873-1076            JAXUCZ010000007.1  54427855-54428058   c
            1077-1205           JAXUCZ010000007.1  54425796-54425924   c
            1206-1318           JAXUCZ010000007.1  54424518-54424630   c
            1319-1418           JAXUCZ010000007.1  54420776-54420875   c
            1419-1488           JAXUCZ010000007.1  54420625-54420694   c
            1489-2775           JAXUCZ010000007.1  54417418-54418704   c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2775
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="RAB3A interacting protein"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
     exon            1..164
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            165..439
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    177..179
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="upstream in-frame stop codon"
     CDS             189..1571
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="isoform 1 is encoded by transcript variant 3;
                     rab-3A-interacting protein; rabin-3; SSX2-interacting
                     protein; rab3A-interacting protein"
                     /codon_start=1
                     /product="rab-3A-interacting protein isoform 1"
                     /protein_id="NP_001424715.1"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
                     /translation="MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPH
                     PSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGL
                     TRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYER
                     LKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATA
                     EKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNKSTSSA
                     MSGSHQDFSAIQPIVKDCREADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLT
                     FAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCKHRI
                     KLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSL
                     AKLGYFKEEL"
     misc_feature    477..>908
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    477..>908
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    627..629
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    633..635
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    705..911
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    705..911
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    924..1028
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62739.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    927..929
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    936..938
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    984..1562
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    984..1562
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    1002..1004
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    1026..1028
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    order(1239..1259,1422..1424,1431..1436,1443..1445,
                     1455..1457,1470..1484)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     misc_feature    order(1239..1259,1422..1424,1431..1436,1443..1445,
                     1455..1457,1470..1484)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     exon            440..698
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..794
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            795..872
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1076
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1205
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1318
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1418
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1488
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2775
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggctct ccctccctcg gctcccatcg cagtgcgccc gccgcggcgg agtggagcgg
       61 cgtctgtccg ccgccgtcct tcgcgtctcc cgagctgggc acgcgcaccc tgcggctctg
      121 cgagcgccgc tgagcgcggg cggcggccgc ggcgggtccg gcaggctgtc ctatgatgaa
      181 gtcttgctat ggctaacgac cccttagaag gtttccatga agtgaacctc gcttcgccta
      241 cctctccaga ccttcttggt gtgtgtgacc cgggaaccca agagcagact acctccccga
      301 gcgtcatcta ccggccacac ccttcgacgt tgtgctctgc cactatccag gccaatgcct
      361 taaatctttc tgaccttccc acacagcctg tgtattcatc cccgaggcat ttaaactgtg
      421 cagaaatatc taacatcagc attcatgttc cagagccagc atcatcggta gcctctgagg
      481 tggcagcagg gctcacgagg ttcacctcaa ggaaggacag ctgcaacgca gagagggagt
      541 ttctgcaggg cgccaccgtc acagaggctt ctgctggcaa cgatgacatc tttgggttga
      601 gcacggacag cctgtcccgt ttacggagcc catctgttct ggaagttaga gagaagggct
      661 acgaaaggtt aaaagaagaa cttgcaaaag ctcagaggga attgaagtta aaagatgaag
      721 aatgtgagag actttcgaaa gtgcgagatc aacttgggca ggagttggaa gaactcacag
      781 ctagtttatt tgaggaagct cacaagatgg tgagagaggc gaacgtcaag caggcaactg
      841 cagaaaagca gctgaaggaa gctcaaggga aaattgatgt gcttcaagcc gaagtggctg
      901 cgctgaagac actcgtactg tccagttctc caacatcgcc tacgcaggag cctctggcgg
      961 ctggaaagac gccctttaaa agggggcaca cacggaacaa aagtacaagc agtgctatga
     1021 gtggcagcca ccaggacttc agtgcgatcc agccaatcgt aaaagactgc agagaggccg
     1081 atctatcgct gtataatgag ttcaggtctt ggaaggatga gcccacaatg gacagaacat
     1141 gtcccttcct agacaaaatc tatcaggagg atatctttcc atgcttaaca ttcgcgaaaa
     1201 gtgagttggc ttcagctgtt ctggaggccg tggagaacaa cactctaagc atcgagccgg
     1261 tagggttgca gcccatccgc ttcgtgaagg cttccgcggt ggagtgcgga gggccaaaaa
     1321 agtgtgctct cactggccag agtaagccct gtaagcacag gattaaacta ggggactcca
     1381 gcagctatta ctacatctct ccggtttgca gataccggat cacttctgta tgtaactttt
     1441 ttacatacat tcgatatatt cagcagggac ttgtgaaaca gcaggatgtt gatcagatgt
     1501 tctgggaagt tatgcaacta agaaaggaga tgtcgttggc aaagctggga tatttcaaag
     1561 aagaactctg atgccctgag tacggggccg tgcgtgctcc tccctggaca gctgaaggat
     1621 gacaacgttt ttatggttac tcaatattta tttctaagga gaaggccaaa gacttccctc
     1681 ctctgcacac cacactatga agtgctgtga tttttttcaa actgactgag ctgtacttgc
     1741 ttatccctta atggaacaca ctctgaagat tgcaggcctg ctagtgatgg taattcaaca
     1801 ctgcaaatcc agaccaccaa ataaacacca gactgaacat gtgtgtcttt cttagctctg
     1861 actcggcata aagttgcaga ggttgatagt agtcttcaca ttgtacccct gtgagagcga
     1921 ggaaggagcc agctggacag ggcttcatgt ctgtgtgtat gctggcattc agacgaaagg
     1981 ttttatttat ttttattctg ccagctgtga tgtagggaat ccttttatca taatgatttg
     2041 ttaagtgtaa taaatgaaga cagtgaacat tcttgggcat cctgacggag ggcttcacgt
     2101 tagcattgag cattatcgtg gaatagaagg agtgttaagt ttaatagacc agggcatggc
     2161 ctaaaaggat acggtctgcc agctctgagc ttctggtgac tgcttcattt ctaaggttgg
     2221 actaatgctg acactcggga agaaacgacc aacatcagat gtacaaataa aagaggttcg
     2281 tagtggagac atagtatagg aaagcaaagg aaaacagccc gcttccttaa ctcgagtaag
     2341 aacactccgc tcacactttt ggagaacacc ttggactgtg aaatatttcc tacttataga
     2401 tgcacaattc tgattgttgt atgtgtgtga atgtgtgtgt gtgtgcatct cacttgggcc
     2461 ttgtgcacac agatctggaa ctggagttgc agacagccgt gagctgccgt ctctccagct
     2521 tgtccctctc gctttaaaag taaataattt ttctacattg tatgtgtcta tgagggtgta
     2581 cctgtgtgtg tgtggcagtc agatgacggc ttttaggagt ctgttctctc ctgtctaggt
     2641 tttcatgatc aaacagactc aggacatcag ggttggtagc aataccttta tgtgctgagc
     2701 catttctctg gtgcggatct ccacatccta atcattgtgt attcatcgca attaaacata
     2761 gtctaattgt ctcta
//
LOCUS       NM_001437720             780 bp    mRNA    linear   ROD 11-APR-2025
DEFINITION  Rattus norvegicus synaptonemal complex central element protein 2
            (Syce2), transcript variant 2, mRNA.
ACCESSION   NM_001437720 XM_006255291
VERSION     NM_001437720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E.
  TITLE     AGO4 regulates entry into meiosis and influences silencing of sex
            chromosomes in the male mouse germline
  JOURNAL   Dev Cell 23 (2), 251-264 (2012)
   PUBMED   22863743
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Costa,Y., Speed,R., Ollinger,R., Alsheimer,M., Semple,C.A.,
            Gautier,P., Maratou,K., Novak,I., Hoog,C., Benavente,R. and
            Cooke,H.J.
  TITLE     Two novel proteins recruited by synaptonemal complex protein 1
            (SYCP1) are at the centre of meiosis
  JOURNAL   J Cell Sci 118 (Pt 12), 2755-2762 (2005)
   PUBMED   15944401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006255291.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.972263.1,
                                           SRR26360186.875040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000019.1  40191849-40191905   c
            58-170              JAXUCZ010000019.1  40191237-40191349   c
            171-324             JAXUCZ010000019.1  40176892-40177045   c
            325-513             JAXUCZ010000019.1  40175006-40175194   c
            514-780             JAXUCZ010000019.1  40173713-40173979   c
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..780
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /note="synaptonemal complex central element protein 2"
                     /db_xref="GeneID:364976"
                     /db_xref="RGD:1311867"
     exon            1..57
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..558
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="synaptonemal complex central element protein 2
                     isoform 2"
                     /protein_id="NP_001424649.1"
                     /db_xref="GeneID:364976"
                     /db_xref="RGD:1311867"
                     /translation="MERQGVAVPPVELKDQEPPAIVESGEHQQNENHEETPSSVAPSA
                     SCQLPGPFSSLDSSIETLKKKAQELIENINESRQKDHALMTNFRDSLKMKVSDLTEKL
                     EERMYQVYSHHSKIIQERLQEFTQKMAKISHLEMELKQVCQTVETMYKDLCVQSEVPT
                     SEEQNYKDGEC"
     exon            58..170
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            171..324
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            325..513
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
     exon            514..780
                     /gene="Syce2"
                     /gene_synonym="RGD1311867"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgcgca gagggcggga acgcggaggc gggaaagacg gaatggagcg ccaaggagtg
       61 gccgtgcctc ccgtggagtt aaaggaccag gaaccgccag cgattgtgga gagcggagag
      121 catcagcaga atgagaacca cgaggagaca cctagctcag tggcgccgag tgccagctgc
      181 caactaccag gacccttctc ctctctggac tctagcattg aaaccctgaa gaagaaagcc
      241 caggaactga ttgaaaacat caatgaaagc aggcagaaag accatgcact tatgaccaac
      301 ttcagggaca gcctcaagat gaaggtctca gatctgacag aaaagttgga ggaaaggatg
      361 taccaggtat acagccacca cagcaaaatc attcaggaaa gactacaaga atttacccag
      421 aagatggcaa agatcagtca tctggaaatg gagctcaaac aagtttgcca aactgtggaa
      481 actatgtaca aggacctatg tgtccagtct gaggttccca cttccgaaga acagaattac
      541 aaggatggtg aatgctgact cctgctaaga ggcttccatc ttaatgcctt gtcaccaaga
      601 gaaggcacag aggctgttta agccatgctg atatgtctta cagttctgta acccaacaca
      661 aagccaccaa ttatgtgtgt gctaattacc aaagtgtgat aaggttagac cctgccatag
      721 gcctagcctt agcaaattct cccaacccac gtctatagtt gattaaatgt tttgatttca
//
LOCUS       NM_173141               1130 bp    mRNA    linear   ROD 12-APR-2025
DEFINITION  Rattus norvegicus tissue factor pathway inhibitor 2 (Tfpi2), mRNA.
ACCESSION   NM_173141 XM_346686 XM_347366
VERSION     NM_173141.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Xu,Z., Zhu,X., Mu,S., Fan,R., Wang,B., Gao,W. and Kang,T.
  TITLE     FTO overexpression expedites wound healing and alleviates
            depression in burn rats through facilitating keratinocyte migration
            and angiogenesis via mediating TFPI-2 demethylation
  JOURNAL   Mol Cell Biochem 479 (2), 325-335 (2024)
   PUBMED   37074506
  REMARK    GeneRIF: FTO overexpression expedites wound healing and alleviates
            depression in burn rats through facilitating keratinocyte migration
            and angiogenesis via mediating TFPI-2 demethylation.
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Jang,Y.J., Kim,H.K., Choi,B.C., Song,S.J., Park,J.I., Chun,S.Y. and
            Cho,M.K.
  TITLE     Expression of tissue factor and tissue factor pathway inhibitors
            during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome
  JOURNAL   Reprod Biol Endocrinol 19 (1), 52 (2021)
   PUBMED   33794911
  REMARK    GeneRIF: Expression of tissue factor and tissue factor pathway
            inhibitors during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Liu,Z., Zhang,J., Gao,Y., Pei,L., Zhou,J., Gu,L., Zhang,L., Zhu,B.,
            Hattori,N., Ji,J., Yuasa,Y., Kim,W., Ushijima,T., Shi,H. and
            Deng,D.
  TITLE     Large-scale characterization of DNA methylation changes in human
            gastric carcinomas with and without metastasis
  JOURNAL   Clin Cancer Res 20 (17), 4598-4612 (2014)
   PUBMED   25009298
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Jian,P., Yan,W.S., Chao,S.L., Liang,P., Zhen,L., Ling,Q.B.,
            Hong,L.Y., Ping,L.Y., Jian,W., Fang,J.M., Ling,L., Dong,W.X.,
            Ming,Z.X. and Jian,N.
  TITLE     Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute
            myeloid leukemia
  JOURNAL   J Pediatr Hematol Oncol 34 (1), 43-46 (2012)
   PUBMED   22052167
REFERENCE   6  (bases 1 to 1130)
  AUTHORS   Ekstrand,J., Razuvaev,A., Folkersen,L., Roy,J. and Hedin,U.
  TITLE     Tissue factor pathway inhibitor-2 is induced by fluid shear stress
            in vascular smooth muscle cells and affects cell proliferation and
            survival
  JOURNAL   J Vasc Surg 52 (1), 167-175 (2010)
   PUBMED   20537494
  REMARK    GeneRIF: TFPI-2 influences smooth muscle cell proliferation and
            apoptosis in vitro in response to fluid shear stress.
REFERENCE   7  (bases 1 to 1130)
  AUTHORS   Obata,R., Yanagi,Y., Tamaki,Y., Hozumi,K., Mutoh,M. and Tanaka,Y.
  TITLE     Retinal degeneration is delayed by tissue factor pathway
            inhibitor-2 in RCS rats and a sodium-iodate-induced model in
            rabbits
  JOURNAL   Eye (Lond) 19 (4), 464-468 (2005)
   PUBMED   15184935
REFERENCE   8  (bases 1 to 1130)
  AUTHORS   Hisaka,T., Kisiel,W. and Rosenbaum,J.
  TITLE     cDNA cloning and tissue distribution of the rat ortholog of tissue
            factor pathway inhibitor-2
  JOURNAL   Thromb Haemost 88 (2), 356-357 (2002)
   PUBMED   12195712
REFERENCE   9  (bases 1 to 1130)
  AUTHORS   Miyagi,Y., Yasumitsu,H., Mizushima,H., Koshikawa,N., Matsuda,Y.,
            Itoh,H., Hori,T.A., Aoki,I., Misugi,K. and Miyazaki,K.
  TITLE     Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the
            gene to chromosome 6
  JOURNAL   DNA Cell Biol 15 (11), 947-954 (1996)
   PUBMED   8945635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173141.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ428954.1, SRR26643285.15233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000004.1  32941137-32941276   c
            141-323             JAXUCZ010000004.1  32940732-32940914   c
            324-506             JAXUCZ010000004.1  32938998-32939180   c
            507-677             JAXUCZ010000004.1  32937658-32937828   c
            678-1130            JAXUCZ010000004.1  32936854-32937306   c
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1130
                     /gene="Tfpi2"
                     /note="tissue factor pathway inhibitor 2"
                     /db_xref="GeneID:286926"
                     /db_xref="RGD:628629"
     exon            1..140
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..745
                     /gene="Tfpi2"
                     /codon_start=1
                     /product="tissue factor pathway inhibitor 2 precursor"
                     /protein_id="NP_775164.2"
                     /db_xref="GeneID:286926"
                     /db_xref="RGD:628629"
                     /translation="MDPATSLRLWNLPLLLVGSALGLASVSAQGNNLEICLLPLDMGP
                     CKALIPKFYYDRDQKKCRRFKYGGCLGNANNFHSRKLCEHTCGNKEKVPWVCRSAVRT
                     YPCDKPNTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEAMCKSLCEPRKSIPSFCSSPK
                     DEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKALKKPKRRKI
                     GDFLPRFWKLRS"
     sig_peptide     53..136
                     /gene="Tfpi2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    146..313
                     /gene="Tfpi2"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    146..313
                     /gene="Tfpi2"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    order(176..190,194..202,245..247,257..259)
                     /gene="Tfpi2"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    order(176..190,194..202,245..247,257..259)
                     /gene="Tfpi2"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    329..490
                     /gene="Tfpi2"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    329..490
                     /gene="Tfpi2"
                     /note="Kunitz/Bovine pancreatic trypsin inhibitor (BPTI)
                     domain; Region: Kunitz-type; cl00101"
                     /db_xref="CDD:444694"
     misc_feature    order(356..370,374..382,425..427,437..439)
                     /gene="Tfpi2"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    order(356..370,374..382,425..427,437..439)
                     /gene="Tfpi2"
                     /note="putative serine protease binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:438633"
     misc_feature    509..670
                     /gene="Tfpi2"
                     /note="Kunitz protease inhibitor (KPI) domain 3 (KPI-3 or
                     K3) of tissue factor pathway inhibitor (TFPI) and TFPI2,
                     and similar proteins; Region: Kunitz_TFPI1_TFPI2_3-like;
                     cd22615"
                     /db_xref="CDD:438658"
     misc_feature    509..670
                     /gene="Tfpi2"
                     /note="Kunitz protease inhibitor (KPI) domain 3 (KPI-3 or
                     K3) of tissue factor pathway inhibitor (TFPI) and TFPI2,
                     and similar proteins; Region: Kunitz_TFPI1_TFPI2_3-like;
                     cd22615"
                     /db_xref="CDD:438658"
     exon            141..323
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..506
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..677
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1130
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcactctcc tccctctctc cgcgcatcca ggcagccgca ccacccggtc gtatggaccc
       61 tgctacatcc ctgagactgt ggaatctgcc gctgctcctg gtgggttcag ctcttggtct
      121 cgcttcagta tctgcccaag ggaataactt agagatctgc ctcttgcctt tggacatggg
      181 accttgtaag gccctcatcc ccaagttcta ctatgacagg gaccagaaga aatgccgcag
      241 attcaagtat ggaggctgcc tgggcaatgc caacaatttc cacagtcgga aactctgcga
      301 acacacttgc ggaaataagg agaaagttcc ttgggtttgt cgatcagcag tcagaacgta
      361 tccgtgtgat aaacccaata cagagttttt cttcaatctg aaaactatga catgtgagcc
      421 tcttaggcct ggtctgtgta gcaggactac gaatgtgttc cccgaggaag ctatgtgtaa
      481 gagcttatgt gaaccaagga aaagtatccc atcattttgc tccagtccaa aagatgaagg
      541 cctgtgttct gctaatgtga cccgctatta ttttaattca agaaacaaag cctgcgagac
      601 cttcacctac actggctgtg gtggcaatga aaataacttt tattacctgg atgcttgcaa
      661 ccgtgcctgt gttaaagcct tgaagaagcc caagagaagg aagataggtg atttcctgcc
      721 gagattttgg aagcttcgtt cttaagcatt ttctcatact caaggaaaca agtcattagt
      781 aatttgcttt tcttgtttta ctgatgtgcc aatatttttt gaatctgtgt gtttttattt
      841 attccaagct gctttccaaa tgtgaaattt tcattttcaa tgtactgttc aaatatttaa
      901 gagactgaat acttgtggtg tatcagatat gaatgtgaac atgacttgcc caacttcttg
      961 ggatagctag cactaagttc agaagacgat ggttactaaa ataacagaag gcaatatacg
     1021 tgtgcaatct taacgtgtct cagcatcaac atggcaaaac catttcatta tgaacttata
     1081 gatttggatt aaattttagg ttccaggaga caagaagctg atttatgaac
//
LOCUS       NM_001437819            1632 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus sulfide quinone oxidoreductase (Sqor), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001437819 XM_006234887
VERSION     NM_001437819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1632)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1632)
  AUTHORS   Augustyn,K.D., Jackson,M.R. and Jorns,M.S.
  TITLE     Use of Tissue Metabolite Analysis and Enzyme Kinetics To
            Discriminate between Alternate Pathways for Hydrogen Sulfide
            Metabolism
  JOURNAL   Biochemistry 56 (7), 986-996 (2017)
   PUBMED   28107627
  REMARK    GeneRIF: The role of Sqor in hydrogen sulfide metabolism in the
            heart and liver
REFERENCE   3  (bases 1 to 1632)
  AUTHORS   Ackermann,M., Kubitza,M., Hauska,G. and Pina,A.L.
  TITLE     The vertebrate homologue of sulfide-quinone reductase in mammalian
            mitochondria
  JOURNAL   Cell Tissue Res 358 (3), 779-792 (2014)
   PUBMED   25130143
  REMARK    GeneRIF: The present report demonstrates the presence and specific
            localization of SQRDL in various mammalian tissues.
REFERENCE   4  (bases 1 to 1632)
  AUTHORS   Jackson,M.R., Melideo,S.L. and Jorns,M.S.
  TITLE     Human sulfide:quinone oxidoreductase catalyzes the first step in
            hydrogen sulfide metabolism and produces a sulfane sulfur
            metabolite
  JOURNAL   Biochemistry 51 (34), 6804-6815 (2012)
   PUBMED   22852582
REFERENCE   5  (bases 1 to 1632)
  AUTHORS   Ackermann,M., Kubitza,M., Maier,K., Brawanski,A., Hauska,G. and
            Pina,A.L.
  TITLE     The vertebrate homolog of sulfide-quinone reductase is expressed in
            mitochondria of neuronal tissues
  JOURNAL   Neuroscience 199, 1-12 (2011)
   PUBMED   22067608
  REMARK    GeneRIF: we demonstrated that the SQRDL protein is expressed in
            neurons, oligodendrocytes, and endothelial cells
REFERENCE   6  (bases 1 to 1632)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 1632)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1632)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006234887.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.15126.1,
                                           SRR26643290.12952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000003.1  130294885-130294935
            52-302              JAXUCZ010000003.1  130318361-130318611
            303-473             JAXUCZ010000003.1  130320797-130320967
            474-527             JAXUCZ010000003.1  130325592-130325645
            528-722             JAXUCZ010000003.1  130330300-130330494
            723-932             JAXUCZ010000003.1  130331246-130331455
            933-1116            JAXUCZ010000003.1  130335284-130335467
            1117-1184           JAXUCZ010000003.1  130337368-130337435
            1185-1363           JAXUCZ010000003.1  130337681-130337859
            1364-1632           JAXUCZ010000003.1  130339006-130339274
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1632
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="sulfide quinone oxidoreductase"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
     exon            1..51
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            52..302
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    54..56
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="upstream in-frame stop codon"
     CDS             69..1421
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /EC_number="1.8.5.8"
                     /note="isoform 1 is encoded by transcript variant 2;
                     sulfide:quinone oxidoreductase, mitochondrial"
                     /codon_start=1
                     /product="sulfide:quinone oxidoreductase, mitochondrial
                     isoform 1"
                     /protein_id="NP_001424748.1"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
                     /translation="MAPLVAVVSSPRARLFACFLRLGTQQAGPLQLHTGACCTAKNHY
                     EVLVLGGGSGGITMATRMKRRVGAENVAIVEPSERHFYQPIWTLVGAGAKELSSSDRS
                     TLSVIPSGVQWIQDRVAELNPDQNCIRTDNGKEISYRYLIIALGIQLDYEKIKGLPEG
                     FAYPKIGSNYSVKTVEKTWKALQDFKEGNALFTFPNTPVKCAGAPQKIMYLSEAYFRK
                     TGKRSKANIIFNTALGTIFGVKKYADALQEIIRERNVSVNYKHNLIEVRADKQEAVFE
                     NLDKPGETHVIHYEMLHVTPPMSSPDVLKRSPVADSAGWVDVDKETLQHKKYPNVFGI
                     GDCTNLPTSKTAAAVAAQSGILDRTISLIMKNQTPTKKYDGYTSCPLVTGYNRVILAE
                     FDYTAQPLETFPFDQSKERISMYLMKADMMPFLYWNMMLRGYWGGPAFLRKLFHLGLS
                     "
     misc_feature    279..1235
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     misc_feature    279..1235
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; Region: FadH2; COG0446"
                     /db_xref="CDD:440215"
     exon            303..473
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            474..527
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            528..722
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            723..932
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1116
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1184
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1363
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1632
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtagttt ctgctgcgcc agcgctgggg cccacggtgt cgctcagccg gcctgatcta
       61 ccctggtgat ggccccactg gttgctgttg tatccagtcc acgtgcccgg ctctttgctt
      121 gtttccttag gctgggcact cagcaggctg gacccctcca attgcatacg ggagcctgct
      181 gcacagccaa gaaccactat gaggtgctgg tacttggtgg gggaagtggt gggatcacca
      241 tggccactcg catgaagagg agagttggag cggagaatgt ggccattgtt gaacccagtg
      301 agaggcattt ctaccagcca atctggacac tagtgggtgc tggtgccaaa gagctgtcct
      361 catcggaccg ttctacactg agtgtgattc catccggtgt gcagtggatt caagatagag
      421 tggcggaact gaacccagat cagaactgta tccgcacaga caatggcaag gagatctcct
      481 acagatatct tatcatcgct cttggaatcc agctggacta tgagaagatt aaaggactac
      541 ctgaaggctt tgcttatcca aaaatagggt ccaattactc agttaagaca gtggagaaga
      601 catggaaggc cctgcaggac ttcaaggaag gcaatgccct tttcaccttc ccaaacactc
      661 cagtgaagtg tgctggtgcc ccccagaaga tcatgtacct atcggaagcc tacttcagaa
      721 agactggaaa gcgatccaag gctaatatca tcttcaacac agcccttgga acaatttttg
      781 gagttaagaa gtacgcagat gctttgcagg agatcattcg ggagaggaac gtttctgtca
      841 actataagca caatcttatt gaggtccgag ctgacaaaca ggaggctgtt tttgagaacc
      901 tggacaagcc tggggagaca catgtgattc attatgaaat gcttcacgtc acgccaccca
      961 tgagctcgcc agatgtcctc aagaggagtc ctgtggccga ttctgctggc tgggtggacg
     1021 tggataagga gactctgcag cataagaaat acccgaatgt gtttggcatc ggggactgca
     1081 ccaacctccc aacttcaaag acggctgctg cagtagctgc ccaatctgga atccttgata
     1141 gaacaatttc tctgattatg aagaatcaaa cacccacaaa aaagtatgat ggctatacct
     1201 cgtgcccact ggtgactggt tacaaccgtg tgattcttgc tgagtttgac tacacagctc
     1261 agcctctgga aaccttcccc tttgatcaga gtaaagaacg aatttccatg tacctcatga
     1321 aggctgacat gatgccgttc ctgtattgga atatgatgct aagaggctac tggggaggtc
     1381 cagccttctt gcgaaagctg tttcatctgg gcctgagtta aagatggctc agcacttgct
     1441 ctttttggat gatgtctgga ccaaaatcac agttactgat tgacatgaca gatccaaagg
     1501 actcagaatc ttacccttta aggagtttct tactggacat gatgaccttt ctagacctct
     1561 gaatagctat catgtgaaca acccagaatg agtctttgga aacatccaaa ataaaattct
     1621 attttataaa ta
//
LOCUS       NM_001437885            2961 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus family with sequence similarity 110, member B
            (Fam110b), transcript variant 4, mRNA.
ACCESSION   NM_001437885 XM_006237840
VERSION     NM_001437885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006237840.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.52945.1,
                                           SRR26360194.1719172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000005.1  23618591-23618642
            53-139              JAXUCZ010000005.1  23666739-23666825
            140-2961            JAXUCZ010000005.1  23724367-23727188
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2961
                     /gene="Fam110b"
                     /note="family with sequence similarity 110, member B"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
     exon            1..52
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            53..139
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     exon            140..2961
                     /gene="Fam110b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    335..337
                     /gene="Fam110b"
                     /note="upstream in-frame stop codon"
     CDS             455..1555
                     /gene="Fam110b"
                     /codon_start=1
                     /product="protein FAM110B"
                     /protein_id="NP_001424814.1"
                     /db_xref="GeneID:500400"
                     /db_xref="RGD:1563403"
                     /translation="MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPN
                     PKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPGAKRVLGSPTLKVFG
                     NHAKTESGVQRETLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRDTTELHRHSFAE
                     SLKVYPTPGRGSPQESSSHVSRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSS
                     SAPPLPPKPKVAAMKSPDADQVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNY
                     CGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRV
                     PYGISAIERNARIIKWLYSIKQARESQKVSHV"
     misc_feature    491..808
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    491..808
                     /gene="Fam110b"
                     /note="Centrosome-associated N terminus; Region: FAM110_N;
                     pfam14161"
                     /db_xref="CDD:464095"
     misc_feature    833..904
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    941..1000
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1094..1213
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1154..1156
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C739; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1199..1525
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1199..1525
                     /gene="Fam110b"
                     /note="Centrosome-associated C terminus; Region: FAM110_C;
                     pfam14160"
                     /db_xref="CDD:464094"
     misc_feature    1343..1345
                     /gene="Fam110b"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC76; propagated from
                     UniProtKB/Swiss-Prot (Q5BJX5.1); phosphorylation site"
     misc_feature    1391..1453
                     /gene="Fam110b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5BJX5.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 agtcttgaat tgaaagcttc aaggactcta cagcctaaaa gtgaaataaa agatacctcc
       61 tgctgcagag agcgctttaa gcaaggaagg ctttccttgg cttctgtctg cattccataa
      121 aatactcctt gccttttagc tctgcctgca gttgagcaca aagacctgaa ggagactccc
      181 acagccttca gggagaagaa aggaggcagc caaggctatt aaaaggaact tgtggcttgt
      241 ggcctttttg tgtaggagca gtctggaagg ggagaaaagt gcaccgaagc cacagtggcg
      301 gttaatgagc tgtgagatga ggcgcagccg cgactgacac tgcttccagg atccttcatc
      361 tgccctttgt gcttcgtgta catgtgtctg ttcaggccgg ccagaggcgc ccagaagagc
      421 atccaccacg gctgccgggg aaagaccgcc caccatgccc acggagacgc tacagacagg
      481 tagcatggtg aagcctgtca gccccgcggg caccttcacg tcggcggtgc ccctgcgcat
      541 cctgaacaaa ggacccgact acttccgcag gcaggctgag cccaacccca agagactcag
      601 tgcggtagag agactagagg ctgacaaggc caaatatgtc aagagccagg aagtgatcaa
      661 tgctaaacag gagccagtga agccggccgt gttggccaag ccccctgtgt gcccaggagc
      721 caaacgagta ctgggcagcc ccactctcaa ggtgttcggc aaccatgcca agaccgagag
      781 cggcgtgcaa cgcgagaccc tcaagcttga gatcctcaag aacatcatca acagctcaga
      841 gggctccagc tctggctctg gccacaagca tagctcccga aactggccgc ctcacaggga
      901 caccactgag ctgcaccggc attccttcgc agagtcgctg aaggtgtacc ctacacctgg
      961 ccgtggcagc ccgcaggaga gcagctccca cgtgagcagg aggctgctgg agcagtctgc
     1021 ggagtccttc ctgcatgtct cacacagctc ctcagacatc cgcaaagtga ccagtgtgaa
     1081 gccccttaaa gccatcccct gcagcagttc tgcccctccc ctgcctccca agcccaaggt
     1141 ggctgctatg aagtcccctg atgctgacca ggtggaacca gcctgtgggg tcagccggag
     1201 accttccctt cagcggtcca agtcagactt gagtgacagg tatttccgag tagatgcaga
     1261 cgtggagagg ttcttcaact actgtggact tgacccagaa gagctggaaa accttggcat
     1321 ggagaacttt gccagggcta attctgacat catatctctc aacttccgca gtgcaagcat
     1381 gatcagctca gactgtgaac agtctcagga cagtaacagt gaccttagaa atgacgacag
     1441 tgccaatgac cgggtgccat acggcatttc tgccatcgag agaaatgcta gaatcatcaa
     1501 gtggctgtat agcatcaaac aagctagaga gtcacagaag gtgtcccacg tgtaagaggc
     1561 gcagtggtga aaaggagggg gggtgggtct gtctgtgcat acaccgttgt gaaggttgtg
     1621 aggtctcctt gaagtgtcgt gagcttctcc actttgtgtt gcttgttgtg caatgttctc
     1681 aagttgcatg cctgtcaaca tggcaactgg cctggcttcc ttctcacacc tcgcagggcc
     1741 ttgctgaaca ctcatctgcc aaaagttccc ggccagaatc tgattagggc tttgctctta
     1801 agcaaaactg tttacagaaa gaaaagaaaa gaaaaaaaaa aaaaaacggt ttcgatttct
     1861 tcaatattta tgtgtttttt gtgtttttat accctgcgct attgtgtctt aattaaaagt
     1921 tttatcaact ggcttttaag ttgagagcag aatctttttg aaacaaaaaa gccactttgc
     1981 ctacatggga gaccataaca ctggggaaat atatgggact tgccaccaaa tacagaatga
     2041 cagccaggct ggagttcatt tatgtgaaat caagtggtgg gccttgacct tgtgcttcac
     2101 atgttggcat tttcttgcca ctttgtgaag cactgtgggg caacagtaca gtcctcggtc
     2161 caattaagtg tatatgttgg tatttttgta gaactgaccc caggaaagac aatcagacaa
     2221 aacccaggat aggaggttct atattgattg ggaggggagg gaagggagac agttgatgct
     2281 gttcaaagtg ggataattca taaatatcta gtattaacct tacagaagtg ccattcgaca
     2341 gctgattaaa gctgatacag aatgctatct ttaaaacatt atttcgttgg attttatttg
     2401 ttttgtgctt ttggccaaga attaactcat gttgtttctc tcccttgctc ccttggtagt
     2461 tgttctgttc agggcggatg ggttggtctt ctgcaggttt gcactctgaa gggaggtgag
     2521 aataccatcc gtgtcagtat agtctccatt ccacagtatc cacgtgctgg ccgcttcaca
     2581 cctcagcagt gtgactctgt tacctcgctt atactcctct ctaaagccgt gggtatttgt
     2641 tagagctcta gaaaactgta gaaacaatat agctttccac tctgttgtct cttgttgcct
     2701 cttcccacaa tagcctgccc tccctcgggg tcatttcagg agctgtgagc cagctgccag
     2761 cgttggcaat ggacgaggag gacacgggtg ggctgctcca ctgcctcaca acccacaggt
     2821 tcgcagcaga agcacctcgg tcctcatcag ctactaggag ccttgaaacg gtgtgaatgc
     2881 tgtaagattc tgtacatact tgagttgttc tggaatctaa gaagaaagtt atgctaataa
     2941 atagctctgg tgtaggcttt a
//
LOCUS       NM_001437881            2287 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus pro-apoptotic WT1 regulator (Pawr), transcript
            variant 1, mRNA.
ACCESSION   NM_001437881 XM_006241317
VERSION     NM_001437881.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Hao,Y., Niu,H., An,S., Wang,M. and Wang,Z.
  TITLE     Downregulation of iNOS, IL-1beta, and P2X7 Expression in Mast Cells
            via Activation of PAR4 Contributes to the Inhibition of Visceral
            Hyperalgesia in Rats
  JOURNAL   J Immunol Res 2018, 3256908 (2018)
   PUBMED   29854833
  REMARK    GeneRIF: this study shows that downregulation of iNOS, IL-1beta,
            and P2X7 expression in mast cells via activation of PAR4
            contributes to the Inhibition of visceral hyperalgesia
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Du,W.W., Li,X., Li,T., Li,H., Khorshidi,A., Liu,F. and Yang,B.B.
  TITLE     The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence
            by targeting Par4
  JOURNAL   J Cell Sci 128 (2), 293-304 (2015)
   PUBMED   25472717
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   de Thonel,A., Hazoume,A., Kochin,V., Isoniemi,K., Jego,G.,
            Fourmaux,E., Hammann,A., Mjahed,H., Filhol,O., Micheau,O.,
            Rocchi,P., Mezger,V., Eriksson,J.E., Rangnekar,V.M. and Garrido,C.
  TITLE     Regulation of the proapoptotic functions of prostate apoptosis
            response-4 (Par-4) by casein kinase 2 in prostate cancer cells
  JOURNAL   Cell Death Dis 5 (1), e1016 (2014)
   PUBMED   24457960
  REMARK    GeneRIF: Phosphorylation by CK2 impairs Par-4 proapoptotic
            functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Wang,Z., Chen,D., Zhang,R., An,S., Zhang,Z. and Ma,Q.
  TITLE     Interleukin-1beta increased the expression of protease-activated
            receptor 4 mRNA and protein in dorsal root ganglion neurons
  JOURNAL   Neurochem Res 38 (9), 1895-1903 (2013)
   PUBMED   23775412
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   MacDonald,J.A., Moffat,L.D., Al-Ghabkari,A., Sutherland,C. and
            Walsh,M.P.
  TITLE     Prostate-apoptosis response-4 phosphorylation in vascular smooth
            muscle
  JOURNAL   Arch Biochem Biophys 535 (1), 84-90 (2013)
   PUBMED   23219599
  REMARK    GeneRIF: Par-4 binding does not block MYPT1 phosphorylation in rat
            caudal arterial smooth muscle.
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Duan,W., Rangnekar,V.M. and Mattson,M.P.
  TITLE     Prostate apoptosis response-4 production in synaptic compartments
            following apoptotic and excitotoxic insults: evidence for a pivotal
            role in mitochondrial dysfunction and neuronal degeneration
  JOURNAL   J Neurochem 72 (6), 2312-2322 (1999)
   PUBMED   10349840
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Boghaert,E.R., Sells,S.F., Walid,A.J., Malone,P., Williams,N.M.,
            Weinstein,M.H., Strange,R. and Rangnekar,V.M.
  TITLE     Immunohistochemical analysis of the proapoptotic protein Par-4 in
            normal rat tissues
  JOURNAL   Cell Growth Differ 8 (8), 881-890 (1997)
   PUBMED   9269897
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Sells,S.F., Wood,D.P. Jr., Joshi-Barve,S.S., Muthukumar,S.,
            Jacob,R.J., Crist,S.A., Humphreys,S. and Rangnekar,V.M.
  TITLE     Commonality of the gene programs induced by effectors of apoptosis
            in androgen-dependent and -independent prostate cells
  JOURNAL   Cell Growth Differ 5 (4), 457-466 (1994)
   PUBMED   8043520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006241317.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38877.1,
                                           SRR26643297.24996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000007.1  45531648-45531760
            114-731             JAXUCZ010000007.1  45532179-45532796
            732-863             JAXUCZ010000007.1  45582043-45582174
            864-898             JAXUCZ010000007.1  45590321-45590355
            899-1046            JAXUCZ010000007.1  45605743-45605890
            1047-1151           JAXUCZ010000007.1  45608522-45608626
            1152-2287           JAXUCZ010000007.1  45610357-45611492
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..2287
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="pro-apoptotic WT1 regulator"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
     exon            1..113
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            114..731
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1238
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="prostate apoptosis response 4 protein;
                     transcriptional repressor Par-4-like protein PAWR; par-4
                     induced by effectors of apoptosis; Prostate apoptosis
                     response protein 4; PRKC, apoptosis, WT1, regulator"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein"
                     /protein_id="NP_001424810.1"
                     /db_xref="GeneID:64513"
                     /db_xref="RGD:69065"
                     /translation="MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAA
                     KSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDE
                     CPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNI
                     PAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRY
                     KSTTSAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQ
                     ENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR"
     misc_feature    240..998
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    420..434
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: B30.2/SPRY domain-binding motif.
                     /evidence=ECO:0000250|UniProtKB:Q96IZ0"
     misc_feature    648..824
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Selective for apoptosis induction in cancer cells
                     (SAC)"
     misc_feature    648..698
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Nuclear localization signal"
     misc_feature    702..704
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Phosphothreonine, by PKA.
                     /evidence=ECO:0000269|PubMed:15657440; propagated from
                     UniProtKB/Swiss-Prot (Q62627.1); phosphorylation site"
     misc_feature    906..908
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96IZ0; propagated from
                     UniProtKB/Swiss-Prot (Q62627.1); phosphorylation site"
     misc_feature    1011..1214
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; Region: Atg16_CCD; cl46300"
                     /db_xref="CDD:480640"
     misc_feature    1011..1214
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; Region: Atg16_CCD; cl46300"
                     /db_xref="CDD:480640"
     misc_feature    order(1017..1022,1026..1031,1038..1040,1047..1052,
                     1059..1064,1068..1073,1080..1085,1092..1094,1101..1106,
                     1113..1115,1122..1127,1131..1136,1143..1145,1152..1157,
                     1164..1169,1173..1178,1185..1190,1194..1199,1206..1211)
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:439196"
     misc_feature    order(1017..1022,1026..1031,1038..1040,1047..1052,
                     1059..1064,1068..1073,1080..1085,1092..1094,1101..1106,
                     1113..1115,1122..1127,1131..1136,1143..1145,1152..1157,
                     1164..1169,1173..1178,1185..1190,1194..1199,1206..1211)
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:439196"
     misc_feature    1113..1235
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62627.1);
                     Region: Leucine-zipper"
     exon            732..863
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..898
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1151
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..2287
                     /gene="Pawr"
                     /gene_synonym="Par-4; Par4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccggcc ggcgagcttg cggctgctgg tcgtccgcgt cgcgggctct ccggctcacc
       61 tggacaaccc tcctccccgc cccgcgcctt gtcccaccga aaagttctcg gagagcgtct
      121 gtccgacagc gcgctctccc ggcgccgtcc ccatctcatt ctcgcttccc aggcaggcgg
      181 cggcggcggg agtcaggagt cgcggcgtga ggggcgcccc cgccggcccc tctgggaaca
      241 tggcgaccgg cggctatcgg agcagcggca gcaccacgga cttcctggag gagtggaaag
      301 cgaagcgcga gaagatgcgc gccaagcaga accccgtggg cccgggttcg agcggcgggg
      361 atccagccgc caagtcccct gcgggaccgc tcgcccagac tacggccgcg gggacctcgg
      421 aactcaacca cggccccgcc ggcgcggccg cacctgccgc ccccgggccg ggcgccctga
      481 actgcgctca cggctcgtcc gcgctgcccc gcggggctcc cggctcccgg cggccggagg
      541 acgagtgtcc tattgccgct ggggccgcgg gagcacccgc gtcccgggga gacgaggagg
      601 agccggatag cgccccggag aagggccgca gctcggggcc cagcgccagg aaaggcaaag
      661 ggcagatcga gaagaggaag ctgcgggaga agcgccgctc caccggcgtg gtcaacatcc
      721 ccgcggcgga gtgcttagat gagtacgaag atgacgaagc aggacagaag gaacggaagc
      781 gagaggatgc tatcacacag cagaacacca tccagaatga agctgcgagc ctcccagatc
      841 caggaacctc ctacctgccc caggacccgt cgagaacagt cccaggcaga tacaaaagca
      901 caaccagtgc cccagaagaa gaaatcttaa atagatatcc ccgaacagat agaagtggct
      961 tcagtagaca caacagagat accagtgcgc ctgctaactt cgcttcaagt agcaccttgg
     1021 aaaagagaat tgaagatctt gagaaggaag tcttgagaga aaggcaagaa aaccttcgac
     1081 ttacgaggct gatgcaagat aaagaagaaa tgattggaaa actcaaggaa gagattgatt
     1141 tgttaaatag agacctcgat gacatggaag acgaaaacga gcaactaaag caggaaaata
     1201 aaactctttt gaaagttgtt gggcagctga caaggtagaa gacgcaaggc tgcctcggtg
     1261 tgggaaacct gcttttaaac cgcggatgaa tgtcatggcg aaggcgcccg tgattcagtg
     1321 cgctgagaga actgtatatt tatttctaga aaacacatgg atctcttctt ctcaaaattt
     1381 actctttctc attactagtt tttaaaaagt gtaaatcccc gtctttcaca tagaagttaa
     1441 catctttagc tattaaaatg ataggtgatg cctcttggtt ctgtgtgata ctcagataat
     1501 atatggttcg aagtagcagc catttgcata tgttttatct atgttagcac atattctccc
     1561 taaaggaaga tgcatagtct ttgtttacat gaattcaaat ccttggggga gttgcctaca
     1621 gatgccctat tactaatgtg tgcgccttcc gtgtgctaat gcctactcat aaagacgcat
     1681 ctgccgtctc gtcctcccac gggctctcct gattccgagt ggtaatagat acactacttt
     1741 gtatagcagt aatcgttcaa aggaaagcta ttttgcagtt atttcatatg ttctagttgg
     1801 ctaaatataa acttaagaaa atacttgaac tgtgttatag taagtgaaaa attactattt
     1861 tgtgtttgaa tattgaaaaa aatttcagta acttctgaaa aacagttaat gtatagtttc
     1921 ttatgtaggt actatcattc tttttttttt attgctctag ggtttactag taaataatgg
     1981 gatatttaaa aagttgttta ttcttcaggc ctcaattgtg tacaatttca gtattgaaga
     2041 agaaaattga tgctgtgaat agcatgtgct tcaaaaatca gaactaaaaa atttttccac
     2101 acttaaaata tgtacacata cgtcagcatg tgtaagcaga gataacacag atatctcagc
     2161 cgattcctga gttggagaca ccctgggatg ctttttgtca atagagaatc atcccataac
     2221 cctaacactg aagattttaa agcaaccata tttgaagatt tataaaataa agttgtcttc
     2281 tattaaa
//
LOCUS       NM_001107419            4168 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus SNF2 related chromatin remodeling ATPase 5
            (Smarca5), transcript variant 2, mRNA.
ACCESSION   NM_001107419 XM_001074047 XM_226380
VERSION     NM_001107419.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4168)
  AUTHORS   Thompson,P.J., Norton,K.A., Niri,F.H., Dawe,C.E. and McDermid,H.E.
  TITLE     CECR2 is involved in spermatogenesis and forms a complex with SNF2H
            in the testis
  JOURNAL   J Mol Biol 415 (5), 793-806 (2012)
   PUBMED   22154806
REFERENCE   2  (bases 1 to 4168)
  AUTHORS   Hargreaves,D.C. and Crabtree,G.R.
  TITLE     ATP-dependent chromatin remodeling: genetics, genomics and
            mechanisms
  JOURNAL   Cell Res 21 (3), 396-420 (2011)
   PUBMED   21358755
  REMARK    Review article
REFERENCE   3  (bases 1 to 4168)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   4  (bases 1 to 4168)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 4168)
  AUTHORS   Torres-Padilla,M.E. and Zernicka-Goetz,M.
  TITLE     Role of TIF1alpha as a modulator of embryonic transcription in the
            mouse zygote
  JOURNAL   J Cell Biol 174 (3), 329-338 (2006)
   PUBMED   16880268
REFERENCE   6  (bases 1 to 4168)
  AUTHORS   Loyola,A., Huang,J.Y., LeRoy,G., Hu,S., Wang,Y.H., Donnelly,R.J.,
            Lane,W.S., Lee,S.C. and Reinberg,D.
  TITLE     Functional analysis of the subunits of the chromatin assembly
            factor RSF
  JOURNAL   Mol Cell Biol 23 (19), 6759-6768 (2003)
   PUBMED   12972596
REFERENCE   7  (bases 1 to 4168)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   8  (bases 1 to 4168)
  AUTHORS   Loyola,A., LeRoy,G., Wang,Y.H. and Reinberg,D.
  TITLE     Reconstitution of recombinant chromatin establishes a requirement
            for histone-tail modifications during chromatin assembly and
            transcription
  JOURNAL   Genes Dev 15 (21), 2837-2851 (2001)
   PUBMED   11691835
REFERENCE   9  (bases 1 to 4168)
  AUTHORS   Strohner,R., Nemeth,A., Jansa,P., Hofmann-Rohrer,U., Santoro,R.,
            Langst,G. and Grummt,I.
  TITLE     NoRC--a novel member of mammalian ISWI-containing chromatin
            remodeling machines
  JOURNAL   EMBO J 20 (17), 4892-4900 (2001)
   PUBMED   11532953
REFERENCE   10 (bases 1 to 4168)
  AUTHORS   LeRoy,G., Orphanides,G., Lane,W.S. and Reinberg,D.
  TITLE     Requirement of RSF and FACT for transcription of chromatin
            templates in vitro
  JOURNAL   Science 282 (5395), 1900-1904 (1998)
   PUBMED   9836642
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226380.4, XM_001074047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4168
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..4168
                     /gene="Smarca5"
                     /note="SNF2 related chromatin remodeling ATPase 5"
                     /db_xref="GeneID:307766"
                     /db_xref="RGD:1308832"
     exon            1..51
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..3033
                     /gene="Smarca5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily A member 5; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily a, member 5"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A member
                     5 isoform 2"
                     /protein_id="NP_001100889.1"
                     /db_xref="GeneID:307766"
                     /db_xref="RGD:1308832"
                     /translation="MEEVFDDGSPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTEL
                     FAHFIQPAAQKTPTSPLKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQEEDEELLTESS
                     KATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTIS
                     LLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVL
                     LPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRL
                     LLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPF
                     LLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNI
                     LMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQ
                     MTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLG
                     INLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEM
                     KLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERG
                     AKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERK
                     ANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIG
                     YKVPRSPDLPNAAQAQKEEQLKIDEAGPLNDEELEEKEKLLTQGFTNWNKRDFNQFIK
                     ANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQR
                     RISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYD
                     ELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPK
                     PSTQKRKMDGAPDGRGRKKKLKL"
     misc_feature    79..2910
                     /gene="Smarca5"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     misc_feature    79..2910
                     /gene="Smarca5"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     exon            52..126
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            127..293
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            294..394
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            395..495
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..675
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            676..831
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            832..963
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1032
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1142
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1369
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1491
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1644
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1777
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1926
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2046
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2157
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2271
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2394
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2527
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2646
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2859
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2967
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..4168
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcggctc cgagcgccac aggcgcgggt cccgcggaca ccgagatgga ggaagtattt
       61 gatgatggat cacctggaaa gcaaaaagaa atccaagaac ctgatcctac atatgaagaa
      121 aaaatgcaaa ctgaccgagc aaatagattt gagtatttat taaagcagac agagctgttc
      181 gcacatttca ttcagcctgc tgctcagaag actccaacct cacccttgaa gatgaaacca
      241 gggcgcccac gggtaaaaaa ggatgaaaaa cagaatttgc tttcggttgg agactaccga
      301 catcgtagaa cagagcaaga ggaggatgaa gagctattaa cagaaagttc caaagcaacc
      361 aatgtttgta ctcgatttga agattctcca tcatatgtaa aatggggtaa actgagagat
      421 tatcaggtcc gaggattgaa ttggctcatc tctctgtatg agaatggcat caatggtatc
      481 cttgcagatg agatgggttt gggaaagact ctgcaaacaa tttctcttct tgggtacatg
      541 aaacactata gaaatattcc tggtcctcat atggttttgg ttcccaagtc tacattgcac
      601 aactggatga gtgaattcaa gagatgggtg ccaacactta ggtctgtttg cttgatagga
      661 gataaagagc aaagagctgc atttgtcagg gatgttctat taccaggaga gtgggatgta
      721 tgtgtcacat cttatgaaat gcttattaaa gagaagtctg tgttcaaaaa atttaactgg
      781 agatacttag ttatagatga agctcacagg ataaaaaatg aaaaatctaa gttgtcagaa
      841 atagtgagag aattcaagac tacaaaccga ctgttgctga cagggacgcc tcttcagaac
      901 aacctgcacg agctctggtc cctgctaaac tttttgttac cagatgtgtt taattcagct
      961 gatgactttg attcctggtt tgatacaaat aattgccttg gggatcaaaa actagttgag
     1021 aggcttcata tggttttgcg tccattcctt cttcgtcgaa ttaaagctga tgttgaaaag
     1081 agtttgcctc caaagaaaga agtaaaaatc tatgtgggtc ttagcaaaat gcaaagggaa
     1141 tggtatactc ggatattaat gaaagacata gacatactga actcagcagg gaagatggac
     1201 aagatgagac tgttgaacat cttgatgcag ctgaggaagt gctgtaacca cccttatctc
     1261 tttgacgggg ctgagcctgg gcctccctac accacagata tgcatctggt taccaacagc
     1321 ggcaagatgg tggtgttgga caaactgctc cctaaattaa aagaacaagg ttcaagagta
     1381 ctaatcttta gtcagatgac aagggtatta gacattttgg aagattattg catgtggaga
     1441 aattatgagt actgcaggtt ggatggacag acaccccatg atgagagaca agactccatt
     1501 aatgcataca atgaaccaaa tagcaccaag tttgtattta tgctaagcac acgtgctggt
     1561 ggtctgggca tcaaccttgc aactgctgat gtagtaattt tatatgattc agattggaat
     1621 cctcaagttg atcttcaggc tatggaccga gcacatagaa ttggacaaac gaagactgtt
     1681 cgagtgttcc gctttataac tgataacact gtggaagaaa gaatagtaga acgtgccgag
     1741 atgaagctca gactggattc catcgtaatt caacaaggga ggcttgtaga tcagaacctg
     1801 aacaaaattg ggaaagatga aatgcttcaa atgattcgac atggtgccac acatgtgttt
     1861 gcttcaaaag aaagtgaaat cactgatgag gatattgatg gtattttgga aagaggtgca
     1921 aagaagactg cagaaatgaa tgaaaagctc tccaagatgg gtgaaagctc acttagaaac
     1981 tttacgatgg atacagagtc cagtgtttat aactttgaag gagaagacta tagagaaaaa
     2041 caaaagattg cattcacaga gtggattgaa ccacctaaga gagaaagaaa agccaactat
     2101 gctgtagatg cgtacttcag ggaagctctg cgtgtcagtg agcctaaagc acccaaggcg
     2161 cctcgacctc caaaacaacc aaatgttcag gatttccagt tctttcctcc acgtttattt
     2221 gaattactgg aaaaagaaat tctatattac aggaaaacta tcggttacaa ggtacctcgg
     2281 agtcctgatc tacccaatgc agcacaggca cagaaggaag agcagcttaa aatcgacgaa
     2341 gcagggcccc ttaatgacga ggagttagag gaaaaagaga agcttctgac tcaggggttc
     2401 actaattgga ataagagaga ttttaaccag tttatcaagg ctaatgaaaa gtggggtcgc
     2461 gatgatattg agaacatagc cagagaagta gaagggaaaa ctccagaaga agtcattgag
     2521 tactcagctg tgttctggga aagatgcaat gagctccagg acatagagaa gattatggct
     2581 cagattgaaa ggggagaggc aaggattcaa agaagaataa gtatcaagaa agcactagat
     2641 acaaagattg gacggtacaa agcacccttt caccaactaa gaatatcgta tggtactaac
     2701 aaagggaaaa actacacgga agaagaggac cgctttctca tttgtatgct tcacaagctt
     2761 ggcttcgaca aggaaaatgt ttatgatgag ttacgacaat gcatccgaaa ctcccctcag
     2821 ttcagatttg attggtttct caagtccaga actgcgatgg agctccagag gaggtgtaat
     2881 accttaatta ctttgattga aagggaaaat atggaactag aagaaaagga gaaggcagag
     2941 aaaaagaaaa gaggaccaaa gccttccaca cagaaacgta agatggatgg tgcccctgat
     3001 ggccgaggaa gaaaaaagaa gctgaaacta tgaatgcgtt ttgtcttata atcactaact
     3061 agtagttctt taatttacgg gtcttcataa gatgttctgt acagtgctca actgttactg
     3121 tcattcagag acatgaggtc atctgcttac tgagctagaa acatagtatg tagtttccct
     3181 tttttaaatg caacagctgt gctgaaattt tttttatcat taacaattga agtaataaaa
     3241 caggcttcat ttattaataa atgtttcatt tgatttattt ttctaatagt ttcatttgtg
     3301 aggattgtgg ctttttatca gctactttaa cacttgtatg gcttaaaaac aagcaaacaa
     3361 gtaaaaaaaa aaaatgcaaa taacatttga ttggtccctt ctacctggtt tgtaattact
     3421 tcacattctt tgctgatttt tttttttttt ttttttttgg tagtactatt gagtctcatc
     3481 tggaaagatt gtgtaaattg cattcttgct tattatagaa tgggggtaag gcaagacata
     3541 ttaattttct gtgcatattt ctgttacact ttctgtttct atggttctga tgtgaatgtg
     3601 ccctattttg ttggatgaat ggcctttttt agttgtatag ccaaagacat ttagtatttt
     3661 ctggttcttt aaggtaatgt attattttgt aaaaggaatt tttttaagta tttggaaaat
     3721 attttgacaa atggcctgca gcagccacaa cttagaaaga taatgtcaga agtgaggtga
     3781 tttttttttt taatttgaat gaccaagcca aaatgaggtg agaatttgtc atactgttat
     3841 aatactaata gaatgtaccc tctcagttta tagtattttt tgagttttta gagtaaatga
     3901 aaattttatt ttattatatt ttacaaataa cttctaagtc ttagtagcaa gatggagtat
     3961 aattccagtt tttattttct atggaataga ctggtgaact ggagaccttg aagcaggaat
     4021 acccagaggc ctttatgtgc tacacatcat ttgtataaag ttttatatgt gcaaattggg
     4081 tacataagca gttctccatt tttctaaggg aatgcaataa atgtagcatc gtgaataaat
     4141 ataactttta taatccttaa agtggtct
//
LOCUS       NM_214458               8622 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus phosphatase and actin regulator 2 (Phactr2),
            transcript variant 2, mRNA.
ACCESSION   NM_214458 XM_218094
VERSION     NM_214458.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8622)
  AUTHORS   Chiocco,M.J., Zhu,X., Walther,D., Pletnikova,O., Troncoso,J.C.,
            Uhl,G.R. and Liu,Q.R.
  TITLE     Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative
            splicing patterns, association of 5'UTR trinucleotide repeat with
            addiction vulnerability, and differential isoform expression in
            Alzheimer's disease
  JOURNAL   Subst Use Misuse 45 (11), 1809-1826 (2010)
   PUBMED   20590401
REFERENCE   2  (bases 1 to 8622)
  AUTHORS   Goldstein,B.A., Hubbard,A.E., Cutler,A. and Barcellos,L.F.
  TITLE     An application of Random Forests to a genome-wide association
            dataset: methodological considerations & new findings
  JOURNAL   BMC Genet 11, 49 (2010)
   PUBMED   20546594
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8622)
  AUTHORS   Wider,C., Lincoln,S.J., Heckman,M.G., Diehl,N.N., Stone,J.T.,
            Haugarvoll,K., Aasly,J.O., Gibson,J.M., Lynch,T., Rajput,A.,
            Rajput,M.L., Uitti,R.J., Wszolek,Z.K., Farrer,M.J. and Ross,O.A.
  TITLE     Phactr2 and Parkinson's disease
  JOURNAL   Neurosci Lett 453 (1), 9-11 (2009)
   PUBMED   19429005
REFERENCE   4  (bases 1 to 8622)
  AUTHORS   Allen,P.B., Greenfield,A.T., Svenningsson,P., Haspeslagh,D.C. and
            Greengard,P.
  TITLE     Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 7187-7192 (2004)
   PUBMED   15107502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced NM_214458.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY500158.1, SRR26643298.147.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  9530860-9531085     c
            227-394             JAXUCZ010000001.1  9497140-9497307     c
            395-475             JAXUCZ010000001.1  9468266-9468346     c
            476-634             JAXUCZ010000001.1  9463224-9463382     c
            635-1181            JAXUCZ010000001.1  9454995-9455541     c
            1182-1384           JAXUCZ010000001.1  9448660-9448862     c
            1385-1541           JAXUCZ010000001.1  9447057-9447213     c
            1542-1597           JAXUCZ010000001.1  9441551-9441606     c
            1598-1659           JAXUCZ010000001.1  9435618-9435679     c
            1660-1797           JAXUCZ010000001.1  9433972-9434109     c
            1798-1874           JAXUCZ010000001.1  9426874-9426950     c
            1875-8622           JAXUCZ010000001.1  9411412-9418159     c
FEATURES             Location/Qualifiers
     source          1..8622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..8622
                     /gene="Phactr2"
                     /note="phosphatase and actin regulator 2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
     exon            1..226
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    148..150
                     /gene="Phactr2"
                     /note="upstream in-frame stop codon"
     CDS             181..1890
                     /gene="Phactr2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="phosphatase and actin regulator 2 isoform 2"
                     /protein_id="NP_999623.2"
                     /db_xref="GeneID:308291"
                     /db_xref="RGD:1303141"
                     /translation="MGQTSVSALSPQPGSVDGLDKASIANSDGPPAGSQTPPFKRKGK
                     LSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGLLKELPDQDGDV
                     TVNFENSNGHMIHIGEEATQEENVGKPEEGNVSVCEKGPPREEQAEEKTAGSSHPKKT
                     TGSKASSSPSASSTSSHPRGPKESLTGKAGAVGTTRGKKKISKQPAAAASRLSPNTVT
                     SETSSLKGELSDTGVESLKPEETVAGAEEEATGKPKAVVVALPPVTVPPSSPALPLPP
                     EDPCTIALDTPMVLVSDGPTLPISALETSPLPGTEEPANRTTPYSSTGLGGSREQAKC
                     FTTKDGPGKAGPQLLTPGQMGDSLESFSAPEDEAPREYQANDSDSDGPILYTDDDDEE
                     DDDDDSTGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIGT
                     KLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRI
                     LRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRF
                     HRP"
     misc_feature    181..321
                     /gene="Phactr2"
                     /note="propagated from UniProtKB/Swiss-Prot (P62025.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    259..261
                     /gene="Phactr2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62025.1); phosphorylation site"
     misc_feature    286..288
                     /gene="Phactr2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75167; propagated from
                     UniProtKB/Swiss-Prot (P62025.1); phosphorylation site"
     misc_feature    391..468
                     /gene="Phactr2"
                     /note="propagated from UniProtKB/Swiss-Prot (P62025.1);
                     Region: RPEL 1"
     misc_feature    397..462
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    397..462
                     /gene="Phactr2"
                     /note="RPEL repeat; Region: RPEL; pfam02755"
                     /db_xref="CDD:460677"
     misc_feature    472..939
                     /gene="Phactr2"
                     /note="propagated from UniProtKB/Swiss-Prot (P62025.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1063..1629
                     /gene="Phactr2"
                     /note="propagated from UniProtKB/Swiss-Prot (P62025.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1249..1251
                     /gene="Phactr2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62025.1); phosphorylation site"
     misc_feature    1414..1491
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1414..1491
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1531..1605
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1531..1605
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1549..1551
                     /gene="Phactr2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P62025.1); phosphorylation site"
     misc_feature    1642..1719
                     /gene="Phactr2"
                     /note="propagated from UniProtKB/Swiss-Prot (P62025.1);
                     Region: RPEL 4"
     misc_feature    1642..1719
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1642..1719
                     /gene="Phactr2"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; Region: RPEL; smart00707"
                     /db_xref="CDD:128947"
     misc_feature    1663..1665
                     /gene="Phactr2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75167; propagated from
                     UniProtKB/Swiss-Prot (P62025.1); phosphorylation site"
     exon            227..394
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..475
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..634
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1181
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1384
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1541
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1597
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1659
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1797
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1874
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..8622
                     /gene="Phactr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccgctggg ccggcttggc cgctgccagg gccgggcgac ccgcgcgcgc ggggagaagg
       61 tgcggggact ggcgggcgcg ggccgagatg agcgcgcggg aggccggcgg cgagcggacg
      121 ggcgcgcgca ggagcggagc agcccggtga ggcggaggcg cggcggggcg gtcacccgcc
      181 atgggccaga cctcggtgtc cgcgctgtcc ccgcagcccg gcagcgttga tggactagac
      241 aaagcctcca tagcaaactc agatggcccc ccagcaggtt cccagacacc tcccttcaag
      301 agaaagggga aactctccac cattggtaaa atcttcaagc cttggaaatg gaggaaaaag
      361 aagaccagtg acaagtttag agagacctca gcagtattag agaggaagat atccaccaga
      421 caaagtagag aggagctgat aagaaggggc ctgcttaagg aattgcctga tcaagatgga
      481 gatgtaacag ttaactttga aaattcaaac gggcacatga tacacatcgg agaggaagct
      541 acccaagagg agaatgtagg gaaacctgaa gaagggaatg tctctgtgtg tgagaaagga
      601 ccacctcgag aggaacaggc agaagagaag acagctggtt cctctcaccc gaagaaaaca
      661 actggttcca aagcctcatc ctcaccatct gcttcgtcca cctcctctca tcccagagga
      721 cccaaggagt cactcactgg caaagcaggc gcggttggga ccacaagggg caagaaaaag
      781 attagcaagc agccagcagc ggcggcatcc cgactgtccc ccaacacagt cacttctgaa
      841 acgtctagtc ttaaaggaga gctctcagac actggggtag agagcctcaa gccagaggaa
      901 actgttgctg gagcagagga ggaggccaca ggcaaaccca aggcggtcgt cgtcgctctg
      961 ccacctgtca cagtaccgcc atcttcacct gcccttcctc tgccccctga ggatccatgc
     1021 actattgcct tggacactcc catggtccta gtcagtgatg gacccaccct gcccatctct
     1081 gccttagaaa caagtccgct ccctgggact gaagaaccag cgaacagaac cactccgtac
     1141 tcaagcaccg gcttaggtgg gagccgagag caggcaaaat gttttacaac caaagatggg
     1201 ccgggaaagg ctggacctca attgctgacc cctggacaga tgggagactc attagaatcc
     1261 ttcagtgccc cagaggatga ggccccaaga gagtaccaag ccaatgactc tgactcggat
     1321 ggacccatct tatacacaga tgatgatgat gaagaagatg atgatgatga cagcactgga
     1381 gaaagtgcat tggcaagtaa gatcagacga agggatacac tcgccatcaa acttggcaac
     1441 agaccatcca agaaagagct agaggacaaa aacatcctgc agcgaacgtc tgaagaagaa
     1501 aggcaggagc tgcgacaaca gatcggaacc aagctggtca ggagactcag ccagaggcca
     1561 accactgaag aattagagca gagaaacatc ttaaaacaaa agaatgaaga agaggagcag
     1621 gaagcaaaaa tggaactcaa acggaggctc agccggaagc tcagcctaag acctactgtg
     1681 gcagagctac aagcccgaag aatcctgcgg tttaatgagt atgtggaagt cacagattcc
     1741 ccggactacg acagacgtgc ggacaagccc tgggccaggt tgacacctgc ggacaaggca
     1801 gcaataagga aagaactaaa tgaatttaaa agcacggaaa tggaagttca cgaagagagt
     1861 cgacagttta caaggtttca ccgtccataa tgaagcatgg gacagcttgg aaataaggac
     1921 cctgacattg cactgagatt tgaatgtgtg tgtttccgtt tcgttgtggt gaaggaggtg
     1981 tacgactcgg ctttggttga agacgctcct caccctgaca gcccagacga gggcaacaag
     2041 ctgagaggcg gatgcggcaa gcctggctgc ccacggtgtg cactgatata aggggcactc
     2101 tgactctctc agctatgttt cagcgggaat tttaatcaaa gaagacaagc agaagacaat
     2161 cgccagtttg gctaccagaa agccatacgg tatagcacgt gtgggttcac aaacaataga
     2221 cattggaatt gctggtggcc accccaacag ggtgggagct gaaactgaga aagagagaga
     2281 accgtttcat tatgttaatg aagagaagaa gagtgaagag aagtatattt ttgaagtagg
     2341 cgttcggtag ctgaggactt cctaagggat ttgggaacct actcaaccaa cgtagattcc
     2401 ttaaagactt cattctagaa cattcttgtt tcaccaataa tggttctgtg tagtagcctc
     2461 tttttttttt ttttttaatg ttgtgccagt gaacccagtt gccagaaaca aatatgagtg
     2521 ttcattcaat gcaaggagct cctaccagct ctcaccaagc atgcttgctc ttgctgtgtt
     2581 gcatgccttt cagtagtaca gccaagccca cactttctta tattgcttcc ctaacgtatg
     2641 agcgctctac aagggtaaca ggaatgaggt cagatgcaat gtgaccctgt aaaactgtgg
     2701 caagcttcag aaataaatct tctgctcttt ccctgtcttg attctctcca aagtcaggaa
     2761 accatccttt agctaaagaa gatgacccgg acagtcatgg taccctttaa acactcaatc
     2821 cagagttgtc acttaagcaa catacaagtg tctgctgcct gctccaagtc ctgagagggg
     2881 atttaaagaa cataccagat agtttaaaat cctgcattaa ttttttttta atattaggtt
     2941 gctgctattt tttttaaaaa aaagtgaaac agtaaaaacc aagcatatga atttaacaaa
     3001 aatatcctga ggcttaaagg aacacagaag acgacttctg gtttatgtaa aggaaacctt
     3061 accttctctg atgaatttgt ggatcatatc catatacccg gtatttactc cccatgccag
     3121 agaagcagta agatccccgg gccagcttcc ccaggagtct gtaatcagtc ttgtttacat
     3181 taaaaagctt cccccctcaa attgttctct tcagtgtccg gccccagcac agaaccccag
     3241 aagggcttac ttgtgatact accttgaatt tcgttgtccc ttaacaattg ttttaagccc
     3301 cttggattaa aagaagaaga aaaagaaggc agaatctata tcatgctttt tttttcctta
     3361 agaaggcaga atctatacca ggtctatctc attctttgat ctggagctat gccgattctg
     3421 aagcctgtaa ttttctattt cgagtgaaca gtcagcctcg aatcagtcaa gtaagtgtag
     3481 gccctgccat tctgtggtat ctggagggac cgcttgaaat ttgatgattt catttaaaag
     3541 tgaacgtggt tagcggcagc ggactgttgt gaaagcccag aggaaccgcg ccacgaggta
     3601 accagcgttc atgcacccac cgccgtgctt agccgtttgc ggtaataaga caaggctgct
     3661 gcctacacta gttcgtctgg ctaacagcat gaggcagact ttgcttttga aatagtgtct
     3721 gtgcgtgcac tagtgtttgt ctttgtcttt gggggcttgc tcgttctatt gttgttttgc
     3781 agtgccggga ctgaaccagg cccttgcgca tgctctgtgt actctaaccc ctgagccaac
     3841 acccctaacc ttcgtttgac aagagtctca actcaaccgt gaatagtaat tttgttctca
     3901 ttacttatag agtagttttc cctcgtgata tcctactatc gtcttagtgt cgtgggaaaa
     3961 agtgacaaga caggtgatgt tccttcgtct atgcttataa tctcgaaacg ttttaaaaac
     4021 cttctaatga aatgtcctca aaatgttgta aattcaagac aggagcaaca cggcttgcca
     4081 ttcaaagtgt gtttcataga aagtttctgt ctggttggtc aaaagaacct tttttcccca
     4141 ctagtggtgc aggtgacaca ggttttaatc ttccacagtt aatgttcaaa atgccacgca
     4201 tcgttgaagc tcccagttca gcccccagta ctgcacaaac gaaaatctgt ctcctgataa
     4261 catctgccag attggtgtta cctacacctt ttcttcatac taactgatac atttcaagaa
     4321 gcttttgtga gaaagtttag aaagctaaaa aattaactac taacggtcta atatttaagt
     4381 aacctgggac cactgatgac ttcattatga tggcctagta cctgttttaa aagccgtggg
     4441 aagaattaaa atatcacgag ccaagctgta cttctcagaa taaggctcta ctttgctggg
     4501 taatttgtaa aggcagaaac gtttaaaggc tacatagcct tagcagcagc tcactcacag
     4561 gtctccatcc aggcatcccc acagaaggca aagctccctc tccctgtaat taccgctctg
     4621 cccactgcca gcatttctgc agtccaacca acaagcagct actctttaag aaaataaatg
     4681 tgtgcagaaa ccagggcgtg cgtgcgtgcg tgcgtgtgtg tgtgtgtgtg catgtgtgtg
     4741 ttgccattgt aacacaattc cagtttttca ctaaagcata ccattaggca atggagtgag
     4801 cgttcctgac tccggagtta tactaaggaa aagaaaatta gcccacctca ctggaggccc
     4861 caacaagaaa agaaactgga ccagacagaa aagccaaagt ggccattcgg agggagaccc
     4921 tgttggtatt acggtattga gaagacacta agctcccttc acgcagcagc ctcgtggtca
     4981 tcaccaacca accaacgtga cgaatgcagt cctaatccgt gttcgccagg ggcaccttgg
     5041 ctggtcattt cctgtaggta tgaaatgtct ggtggttttg tgtgagctat aatttacctt
     5101 tatgtttatt ccttaagttg ttttaacccg aagtctgcaa tatccagaga accatctcgg
     5161 gtatttgagc acctattaaa ggaaaggcaa gcatatccat ctctctgcct tcccagtgaa
     5221 gaagctgact ttctggtttc tttcttcttg cccttatcaa cccaatgaac gcagttctct
     5281 gtctccgatg tcgggagaaa gttctggaac ttaattgcaa atatatttaa ggaaagagaa
     5341 gaatctaata agcctttcaa aaaccaccaa gtatggaaat gagtcgtgag tcctgagaaa
     5401 aggtcaggca ggctttgtat cctgtaatta acccagcgat ccattggcgc ttttttaaaa
     5461 atacaggagt ttgtactcga gggagaacat gggttcatct cacatgtcca gatacgtgca
     5521 accccacagc aacacatgcc ggacacccgt gaccgttagg ctgtaggcac actagaaaga
     5581 ggccggtctg ccatgtagca gcggtctgtc tgcatttgaa cagtaaaaaa tagtttcctc
     5641 ttctccatgt cttgttctaa aacatccatc ctgtgttgct tgggcttggc cctagccgcg
     5701 tattttagag acatcaacat tccttagtgt atgtgaaacg ggcttaatct aacacaggat
     5761 gtatggattt atgtcctttt cctcctcggc acggcggatt tgtttatgca ttcctaaatc
     5821 cccacttcac ttacttatcg ttacaagtac ggggagctct actggggagg tcatttttcc
     5881 ttcagggctg tacaggacac agattgtccc ttcacccctt aaaatgatta atcctttgtt
     5941 agtattcgct gtctattgac tggctgatat gtttttattt aacaaaagca gaacgaacct
     6001 ttaggagata tgtgctagag gggccaacgg ggacaaaaaa taagcaattg tcaaattaat
     6061 gagaacagct tcctgaaaga aaccatattc tcaggcaact caaagtcgag ctccacagag
     6121 ggactctagg tctccctaca gaggcactcg gggaccaaag ggtgatggag atggaggtga
     6181 ccattctcgt ttttgcttcc tgtttccctt ttctaatcgt taagtctaaa acctcttttg
     6241 aagcttgaac cactgttggc atttctagaa agcaactgta ataggggcta gtgcttttct
     6301 ttctttcttt ctttctttct ttctttcttt ctttctttct ttttttagta tgactgtatt
     6361 ttgttttgtt tgtttgttga ggccagcttc accccataat tttttttaaa aaaatttcat
     6421 tttttacatt taaaaaaaat gcaagttttt ttttcccaaa gaaatggaga gtcctgtggc
     6481 tgctatcccg gcctaatgcc agtttttaac catgttgggt tgtgctgcag ggaaatgcca
     6541 gttagcctgt tgcttcttta acacagctgc ctgtgaacaa agaagcgctg atagatgtct
     6601 cccggtgggg gtgctgttgg tatttggatc tgggtaaatc cttgctgtgc tgaaatgtac
     6661 cacatgttgc aagatgttca gtatcctggg ctcctggtga ctcaacacca gacattgtga
     6721 gaaccggaaa aaaagaaaag aaaagaaaag aaaagaaaag aaaagaaaag aaaagaaaag
     6781 agaagaaaaa agcttcccgt ttgcctgcat agaaggataa acccctcacc tgagtgccac
     6841 tgtctcctgc aacaagggta catgggggaa cctgcctgtc tctaaatacc atgtctactg
     6901 ccttgcacgt ctctacccac ttctctttca aagccttctg cttagatgca gcttaaactg
     6961 gcctgttccc tagaaaagag cttcctaggt agtcttgtcc attacggtgg gcagcgtgac
     7021 atggcctgat atttctggag ggtacacgaa gcaagtcttg ttcattactt ctgtgttact
     7081 tcagaactag actcctggtt gccagaacac agtgtctctg agtaaaacac tggtctttgg
     7141 aactcagcat tggattctac ctggtcatac tgaagaccga gttgcaaaaa gagtctccct
     7201 tcctcctgtt gacaacggag ttaatccaca caaaaagaca cggggactcc ctcgtgtaaa
     7261 catccacacg gttccgcttt cctaataaga cgtgcaaata tgacatgttg gcaggaacgt
     7321 aggtaaactg gattgcattc atgctgttca caccacagac gggcaaaacg aaatgagttt
     7381 tcccccaggt gtagctcgat caagctgtgc taaccgtaca gaaagacgct ctttacgcca
     7441 ctgaaattaa atagtcagtg ggtcttgaaa aatatttaga tgaattgcag ctagctgcaa
     7501 ggatggaatt aattcctccc attcttcaca ttaaaattct gaagactccc cgcccctccc
     7561 ccttctttta agcatagcaa cttggagtca gtaaaggtgg ccatagcgta aacctataga
     7621 tggtgcttta aaacaaaatc gtatctttct taatagcagt attttttaaa gcagagaata
     7681 gactgaaaga agtaaatgcg gcagaacgct gttccacact caggtaaatt ttgtggttta
     7741 ttaaaatgcc aataatattt gtgcacttgc cagcgtcagg ggcttttccc ttaatggatg
     7801 ctctcggtgt gatttttttc ctcttcttta actgtatcgt tacattgttt agagagcatc
     7861 caccaccagg atttgccacc gtagtgataa ctagcattag gaaagaatta ccgagaactg
     7921 agggtcaaac cactttcatc acctaaacga caggcactag ttctttagta tttcttcagt
     7981 ggcttgggtg tgcccatgta ttcaaagcat tccgcacgaa ttttaccagt taaataccgg
     8041 ctgaaaagtc agaccagtct ctctccgcac ctcctctctc tgtaacaatg tttcgttttt
     8101 gttttgtttt tttcccataa tgagctgtct gtgttctttt gttatttcaa actttggttc
     8161 aagtggtagc aatggtacac actgtgatgg tggggagact agctgggtga gtctctagtg
     8221 tgtgatctaa tctttacatg ggtgtgctat ctgtgggtgt tgataactgg aactgtaccc
     8281 ggacaacacg acagtttctc tctcttcctg ttcctgattc actactatat catagtacgt
     8341 gggtatgacc cctgcgagta tccacaccga agcctatgta ttccacaatt gtaacctgaa
     8401 agaccatgca ttatcttttt ttaattcata ctggtgtttg tgttatttaa agtggaaaat
     8461 tataccctat ctagtagtat aatgtaatat aataggatac tccgctgtgc acagttccaa
     8521 gtgccttaga acattgttta gctttcctaa gtatacgtaa atgcatatat gtgtgtataa
     8581 aattgggaaa tgttacctca ataaagtcat tgggaaatcc ta
//
LOCUS       NM_001437878            1729 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus megakaryocyte-associated tyrosine kinase (Matk),
            transcript variant 1, mRNA.
ACCESSION   NM_001437878 XM_063264199
VERSION     NM_001437878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Gunn,N.J., Gorman,M.A., Dobson,R.C., Parker,M.W. and Mulhern,T.D.
  TITLE     Purification, crystallization, small-angle X-ray scattering and
            preliminary X-ray diffraction analysis of the SH2 domain of the
            Csk-homologous kinase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 336-339
            (2011)
   PUBMED   21393838
  REMARK    GeneRIF: The CHK SH2 was expressed in Escherichia coli and the
            purified protein was characterized as monomeric by synchrotron
            small-angle X-ray scattering in-line with size-exclusion
            chromatography.
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Kuo,S.S., Moran,P., Gripp,J., Armanini,M., Phillips,H.S.,
            Goddard,A. and Caras,I.W.
  TITLE     Identification and characterization of Batk, a predominantly
            brain-specific non-receptor protein tyrosine kinase related to Csk
  JOURNAL   J Neurosci Res 38 (6), 705-715 (1994)
   PUBMED   7807586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063264199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.794511.1,
                                           SRR26643298.37819.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000007.1  9113096-9113234     c
            140-199             JAXUCZ010000007.1  9112131-9112190     c
            200-313             JAXUCZ010000007.1  9111468-9111581     c
            314-429             JAXUCZ010000007.1  9111257-9111372     c
            430-649             JAXUCZ010000007.1  9110951-9111170     c
            650-743             JAXUCZ010000007.1  9110597-9110690     c
            744-809             JAXUCZ010000007.1  9109717-9109782     c
            810-909             JAXUCZ010000007.1  9109164-9109263     c
            910-994             JAXUCZ010000007.1  9108992-9109076     c
            995-1068            JAXUCZ010000007.1  9108841-9108914     c
            1069-1267           JAXUCZ010000007.1  9108550-9108748     c
            1268-1354           JAXUCZ010000007.1  9108173-9108259     c
            1355-1729           JAXUCZ010000007.1  9107711-9108085     c
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1729
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
     exon            1..139
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            140..199
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="upstream in-frame stop codon"
     CDS             191..1594
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     megakaryocyte-associated tyrosine-protein kinase; protein
                     kinase BATK; tyrosine-protein kinase CTK;
                     megakaryocyte-associated tyrosine kinase (non-receptor
                     protein tyrosine kinase); non-receptor protein kinase
                     protein"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein kinase
                     isoform 1"
                     /protein_id="NP_001424807.1"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
                     /translation="MPTQRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKS
                     WYRAKHHSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGL
                     FLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTRDKG
                     AICTKLVKPKRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKV
                     AVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLR
                     TRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK
                     AELRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE
                     VSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKLGRELRSVGVAAP
                     AGGQEAEGSAPTRSQDP"
     misc_feature    191..250
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    215..391
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    215..391
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src Homology 3 domain superfamily; Region: SH3;
                     cl17036"
                     /db_xref="CDD:473055"
     misc_feature    order(236..238,242..244,251..253,263..265,320..325,
                     368..370,374..379)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    order(236..238,242..244,251..253,263..265,320..325,
                     368..370,374..379)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212690"
     misc_feature    419..712
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    419..712
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="Src homology 2 (SH2) domain found in
                     Carboxyl-Terminal Src Kinase (Csk); Region: SH2_csk_like;
                     cd09937"
                     /db_xref="CDD:198190"
     misc_feature    order(452..454,506..508,569..571,575..577)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(452..454,506..508,569..571,575..577)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198190"
     misc_feature    order(572..574,653..655)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    order(572..574,653..655)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198190"
     misc_feature    749..1513
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    749..1513
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(788..799,806..808,812..814,845..847,851..853,
                     932..934,977..988,1121..1123,1133..1138,1142..1144,
                     1172..1177)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    order(788..799,806..808,812..814,845..847,851..853,
                     932..934,977..988,1121..1123,1133..1138,1142..1144,
                     1172..1177)
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    1523..1591
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="propagated from UniProtKB/Swiss-Prot (P41243.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            200..313
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            314..429
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            430..649
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            650..743
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            744..809
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            810..909
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            910..994
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1068
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1267
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1354
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1729
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaggaccc gcaggggctc cgagccggtc ccctccatcc ttgccccaaa atgaggaagc
       61 cttgcaagtt gctcggagtt gagccaccag ggcgctcggc cggctggcag ggaccctcca
      121 ggggtcgcgc cctaagcagg tgaaccctca attctaagga gcttggcacc ccacgcctgc
      181 tgcagctaag atgccaacgc aacgctgggc ccctgggact caatgtatga ccaagtgcga
      241 gaactcacgc cccaagcccg gtgagctagc ctttcgaaag ggtgacatgg tgaccatctt
      301 ggaggcctgt gaggacaaga gctggtaccg agccaagcac cacagcagtg ggcaggaagg
      361 gctgctggcg gctgctgctc tgcgacagag ggaggccctt tccacagacc ccaagctcag
      421 cctcatgcca tggttccatg gcaagatttc cggtcaggaa gccatacagc agctgcagcc
      481 acccgaggat gggctgttcc tcgtgaggga atcggcccgt caccctggtg actatgtcct
      541 gtgtgtcagt ttcggccgtg atgtcatcca ctaccgtgtc ttgcatcgag atgggcacct
      601 caccattgat gaggccgtgt gtttctgtaa tctgatggac atggtagagc actacaccag
      661 ggacaagggc gccatctgca ccaagctggt gaagcccaag aggaaacagg gcgcaaagtc
      721 cgcagaggaa gagctcgcca aggctggctg gctgctagac ctgcagcatc tgactctggg
      781 agcacagatt ggagagggag agtttggagc cgtcctgcag ggcgagtact tgggacagaa
      841 ggtggccgtg aagaatataa agtgtgatgt gacagcccag gccttcctgg atgagacggc
      901 tgtgatgaca aagctgcagc acaggaacct agtgcgactc ctgggtgtga tcctgcacca
      961 cggcctgtac attgtcatgg aacacgtgag caagggcaac ctggtgaact tcctgcgcac
     1021 gcggggccgt gcgcttgtga gcacctctca gctcctgcag tttgctcttc acgttgctga
     1081 aggcatggag tacctggaga gcaagaagct ggtacacagg gacctggctg ctcgaaacat
     1141 cctggtctct gaggacttag tggccaaggt cagtgacttt ggcctagcaa aggcagagct
     1201 taggaagggg ctggactcaa gtcggctgcc agtcaagtgg acagcacccg aggctctcaa
     1261 aaatgggagg ttctccagca agtcggatgt ctggagtttt ggggtgctac tgtgggaagt
     1321 cttctcatat ggaagagccc cataccccaa gatgtcgcta aaggaggttt cagaggctgt
     1381 ggagaagggt taccgcatgg agccccccga cagctgccca ggccctgtgc ataccctcat
     1441 gggcagctgc tgggaggctg agccctcgcg cagaccaccg ttccgcaaaa tagtggagaa
     1501 gctgggtcgt gagctccgca gtgtgggcgt cgcagccccc gccgggggac aggaggctga
     1561 gggctcagct cccacacgga gccaggaccc ctgacccctg aactggaaag caagaggaca
     1621 cagatgtagg gtcacagggc cagggtgagc cagtgcacag gctccggagc ccctgggatc
     1681 cccgttactg ggacacccca taaagagtga ttggaaggat tttgtacaa
//
LOCUS       NM_001437874            4138 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus growth hormone receptor (Ghr), transcript variant
            3, mRNA.
ACCESSION   NM_001437874 XM_008760754
VERSION     NM_001437874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4138)
  AUTHORS   Klammt,J., Shen,S., Kiess,W., Kratzsch,J., Stobbe,H., Vogel,M.,
            Luo,F. and Pfaffle,R.
  TITLE     Clinical and biochemical consequences of an intragenic growth
            hormone receptor (GHR) deletion in a large Chinese pedigree
  JOURNAL   Clin Endocrinol (Oxf) 82 (3), 453-461 (2015)
   PUBMED   25196842
REFERENCE   2  (bases 1 to 4138)
  AUTHORS   Deng,H.Z., Deng,H., Cen,C.Q., Chen,K.Y. and Du,M.L.
  TITLE     Post-receptor crosstalk between growth hormone and insulin signal
            in rats born small for gestational age with catch-up growth
  JOURNAL   PLoS One 9 (6), e100459 (2014)
   PUBMED   24963636
  REMARK    GeneRIF: receptor crosstalk between growth hormone and insulin
            signal in rats born small for gestational age with catch-up growth
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4138)
  AUTHORS   Claessen,K.M., Kloppenburg,M., Kroon,H.M., Bijsterbosch,J.,
            Pereira,A.M., Romijn,J.A., van der Straaten,T., Nelissen,R.G.,
            Hofman,A., Uitterlinden,A.G., Duijnisveld,B.J., Lakenberg,N.,
            Beekman,M., van Meurs,J.B., Slagboom,P.E., Biermasz,N.R. and
            Meulenbelt,I.
  TITLE     Relationship between the functional exon 3 deleted growth hormone
            receptor polymorphism and symptomatic osteoarthritis in women
  JOURNAL   Ann Rheum Dis 73 (2), 433-436 (2014)
   PUBMED   23740230
REFERENCE   4  (bases 1 to 4138)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4138)
  AUTHORS   Enhamre,E., Carlsson,A., Gronbladh,A., Watanabe,H., Hallberg,M. and
            Nyberg,F.
  TITLE     The expression of growth hormone receptor gene transcript in the
            prefrontal cortex is affected in male mice with diabetes-induced
            learning impairments
  JOURNAL   Neurosci Lett 523 (1), 82-86 (2012)
   PUBMED   22750159
REFERENCE   6  (bases 1 to 4138)
  AUTHORS   Frick,G.P. and Goodman,H.M.
  TITLE     Characterization of the short isoform of the growth hormone
            receptor synthesized by rat adipocytes
  JOURNAL   Endocrinology 131 (6), 3083-3090 (1992)
   PUBMED   1446642
REFERENCE   7  (bases 1 to 4138)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 4138)
  AUTHORS   Godowski,P.J., Leung,D.W., Meacham,L.R., Galgani,J.P., Hellmiss,R.,
            Keret,R., Rotwein,P.S., Parks,J.S., Laron,Z. and Wood,W.I.
  TITLE     Characterization of the human growth hormone receptor gene and
            demonstration of a partial gene deletion in two patients with
            Laron-type dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8083-8087 (1989)
   PUBMED   2813379
REFERENCE   9  (bases 1 to 4138)
  AUTHORS   Baumbach,W.R., Horner,D.L. and Logan,J.S.
  TITLE     The growth hormone-binding protein in rat serum is an alternatively
            spliced form of the rat growth hormone receptor
  JOURNAL   Genes Dev 3 (8), 1199-1205 (1989)
   PUBMED   2792761
REFERENCE   10 (bases 1 to 4138)
  AUTHORS   Mathews,L.S., Enberg,B. and Norstedt,G.
  TITLE     Regulation of rat growth hormone receptor gene expression
  JOURNAL   J Biol Chem 264 (17), 9905-9910 (1989)
   PUBMED   2722883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008760754.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.8824.1,
                                           SRR26643285.7354.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000002.1  54532095-54532325   c
            232-310             JAXUCZ010000002.1  54418526-54418604   c
            311-376             JAXUCZ010000002.1  54351981-54352046   c
            377-506             JAXUCZ010000002.1  54304431-54304560   c
            507-679             JAXUCZ010000002.1  54298368-54298540   c
            680-858             JAXUCZ010000002.1  54285767-54285945   c
            859-1027            JAXUCZ010000002.1  54279713-54279881   c
            1028-1118           JAXUCZ010000002.1  54277635-54277725   c
            1119-1188           JAXUCZ010000002.1  54272313-54272382   c
            1189-4138           JAXUCZ010000002.1  54269066-54272015   c
FEATURES             Location/Qualifiers
     source          1..4138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4138
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
     exon            1..231
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..117
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="upstream in-frame stop codon"
     exon            232..310
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2157
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; growth hormone receptor/binding protein; GH
                     receptor; somatotropin receptor; growth hormone receptor
                     variant d5-6"
                     /codon_start=1
                     /product="growth hormone receptor isoform 1 precursor"
                     /protein_id="NP_001424803.1"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
                     /translation="MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLR
                     ESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECP
                     DYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLL
                     NISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLY
                     SLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGI
                     FGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYK
                     PDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYD
                     PDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITL
                     TMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIK
                     AGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIY
                     ITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSS
                     CGYVSTDQLNKIMQ"
     sig_peptide     241..294
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1)"
     mat_peptide     295..2154
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /product="Growth hormone receptor. /id=PRO_0000010969"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1)"
     misc_feature    385..621
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    385..621
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    583..585
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    685..990
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    685..990
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(685..687,904..906,955..957)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(685..687,904..906,955..957)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    706..708
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    721..723
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    838..840
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); glycosylation site"
     misc_feature    958..972
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: WSXWS motif.
                     /evidence=ECO:0000250|UniProtKB:P10912"
     misc_feature    order(958..963,967..972)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(958..963,967..972)
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1036..1107
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     transmembrane region"
     misc_feature    1123..1380
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Required for JAK2 binding.
                     /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    1132..1158
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Box 1 motif. /evidence=ECO:0000269|PubMed:8063815"
     misc_feature    1189..2088
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    1189..2088
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Growth hormone receptor binding; Region: GHBP;
                     pfam12772"
                     /db_xref="CDD:463696"
     misc_feature    1261..1290
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: UbE motif. /evidence=ECO:0000305|PubMed:7615519"
     misc_feature    1264..1266
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    1309..1407
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="propagated from UniProtKB/Swiss-Prot (P16310.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1699..1701
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     misc_feature    2020..2022
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10912; propagated from
                     UniProtKB/Swiss-Prot (P16310.1); phosphorylation site"
     exon            311..376
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            377..506
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            507..679
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            680..858
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1027
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1118
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1188
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..4138
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagcccac gagctgccaa gcagggcgca gccatgggaa gaggaggcgg tctagggagc
       61 ggcggcactg gcagaagcgg ctgttacagc ggcggtggcg gcgacggctg ttgctgagcc
      121 ccggcagccg cgaggacccc gggctggggc cacgcgggcc tgaggcctcg gctccagcag
      181 cccccaagcg gacgcgaacc cgcgctctgt ctcccaaggc gaagctccga ggtctcaggt
      241 atggatcttt ggcgggtgtt cttaaccctg gcactggcag tctccagcga catgtttcct
      301 ggaagtgggg ctacaccagc tactcttggc aaagcttccc cggttctgca aagaattaat
      361 ccaagcctga gggaaagttc ctctggaaag cctcgattca ccaagtgtcg ttcccctgaa
      421 ctggagacct tttcatgcta ctggacagaa ggggatgatc ataatttaaa ggtcccggga
      481 tctattcagc tatactatgc tagaagaatt gctcatgaat ggaccccgga atggaaagaa
      541 tgccctgatt atgtctctgc tggagcaaac agctgttact tcaactcatc gtatacctcc
      601 atttggatac cctactgcat taagcttact acaaatggtg atttgttgga cgaaaagtgt
      661 ttcactgttg atgaaatagt gcaacctgat ccgcccattg gcctcaactg gactttacta
      721 aacatcagtt tgcctgggat ccgtggagat atccaagtga gttggcagcc accgcccagt
      781 gccgatgttc tgaagggatg gataattctg gagtatgaaa ttcagtacaa agaagtaaat
      841 gaaacaaaat ggaaaacgat gagcccgata tggtcaacat cagtcccact gtactcactg
      901 agactggata aagagcacga agtgcgtgtg agatccagac aacggagctt cgaaaagtac
      961 agcgagttca gtgaagtact ccgtgtaacg tttcctcaga tggacacact ggcagcatgt
     1021 gaagaagatt tccggtttcc atggttctta attattatct ttggaatatt tggagtagca
     1081 gtgatgctat ttgtagttat attttcaaag cagcaaagga ttaagatgct gattttaccc
     1141 ccagtaccag ttccaaagat taaagggatt gatccagatc ttctcaagga aggaaaattg
     1201 gaggaggtga acaccatctt gggcattcat gataactaca aacccgactt ctacaatgat
     1261 gactcctggg ttgagttcat tgagctggat attgatgatg cggatgagaa gactgaagag
     1321 tcagacaccg acagacttct aagcgatgac caggagaaat cagctggtat ccttggagca
     1381 aaggatgacg attctggacg taccagctgt tatgaccctg acattttgga taccgatttc
     1441 cacaccagtg acatgtgcga tggtacctcg gagtttgctc agccgcagaa gttaaaagca
     1501 gaagctgatc tcttgtgcct tgaccagaag aatctgaaga actcgcctta tgatgcttcc
     1561 cttggctctc tgcacccctc cattaccctg acaatggaag acaaaccaca gccacttctg
     1621 ggcagtgaaa ctgagtcaac ccaccaactc ccctctacac caatgagcag tcccgtgtca
     1681 ctggcaaaca ttgactttta tgcccaagta agcgacatta caccagcagg tggtgtagtc
     1741 ctttctccag gccaaaagat taaggcaggg ttagcccagg gcaacaccca gctggaggtg
     1801 gccgcgccct gccaagaaaa ttacagcatg aacagtgcct acttctgtga gtcagatgcc
     1861 aaaaagtgca tcgctgcggc ccctcacatg gaggccacga catgtgtaaa accaagcttt
     1921 aaccaagagg acatttacat caccacagaa agccttacca ctactgcccg aatgtccgag
     1981 acagcagata ccgctccaga tgctgagcct gtcccagact acaccacggt tcacaccgtg
     2041 aagtccccaa ggggccttat actcaacgcg actgctttgc ctttgcctga caaaaagaag
     2101 tttctctcct catgtggcta tgtgagcaca gaccaactga acaaaatcat gcagtagcct
     2161 ttcctatctt taatggcaaa agaaatgact gggcacgaac gcctaaacca aaactatgtt
     2221 ttaaatctgt gttgggagag cgtgagagtg aatgtggatt caaaaatacc ttttctggaa
     2281 acgtcgaaac attatcataa cgtggaaaat caagaatatg taatcagata gatactccca
     2341 ttgtgaattt taaatatttt aaagaatcgt ctttaagact gtttagtggc agtgattgtc
     2401 tgtgctgtgg gtcttaactt tgtgatacta agtattaaat agctacgttt ttcatgtatg
     2461 tagatcatgc ttttttgaaa aagcaaaaca atcaggtggc ttttgcagtt caggaaattg
     2521 aatgcagatt ttagcacaga ctgatttctt tttccttttt aaatagctag gagctaaaac
     2581 tctaggggag aaggtaaaac tagtttggat atgcaaaaca tttattttga cataaaattg
     2641 ataaagatat ttttaataat ttacactgta agcatgagta ttttataata cactacagat
     2701 atattgtagt tcacaacaat ccatctacgg atgtaacaac tacaatgtgt agaggggttg
     2761 atgctttggt caatgaacct aaagaaaaat gaacaagtta gatttttaca aagccctttt
     2821 ttataactcc caaaacttct taaatctaaa aatgtctgca ttattggaac aaacccattt
     2881 taaatttgta aatgaatatt tttttaattt tgaaaacttt aattttttat acaaattaac
     2941 gtatcataca ccaaacagta acagaagtga ttataataat ggaagaaaca gtttcttcac
     3001 caaatttcca ttcaagccac aaggctgtgt gtaagagaag tagaagtgat gtggtgtgac
     3061 tggctaggat aaaggagatc ttcaggagca catgggttta gagagcccag ggatcaggaa
     3121 aaggaggctc tcacatctga gcagtgctgt cctttcaaac acagcttggc ttttatagta
     3181 acctaagaat taatgcatac aaggaggagt ttcacatgtg tgaaatccaa tagcagatgg
     3241 gttaaagtta aacaagttat agcacaggaa attaaagacc tagatctttg tttcgcagtc
     3301 agacacatac ttttaattca gggagaaaag ggacagaata aatgacttca cagtcacaag
     3361 gcacacctca gaagtagtta aacaagtaac agaaaccttg ttatcaaacc tttaataaga
     3421 tgtattttaa atagtaagca gtatttcatt gcttcttacc ctcccagaga gattgatctc
     3481 aaataaggta ggaaaacaaa caatataaaa atcactttaa ttatgtaata acatagacac
     3541 agctctttgg gttagccccc caaaagattt atgagagaag gaggactttc agccaactga
     3601 agaatacttc tcattttaag cactttttag atgcttgaaa ctttaaaatt acctttaact
     3661 ttcaatgata tttaccattt tgcagagacc tttgtgggga aacaggctta atgtttagtg
     3721 gtttttaaat ctctttcatg caggagagac agtgaaaaat ttagacttgg gtgtttaagg
     3781 ttcactgtgt tattctgtag tagattttaa tagatttttt tctgctacct tgctgctatg
     3841 gtttccccaa tggctacatg atttagttca tatgaagtat catcaactta gaacctattc
     3901 agcttaaaga tgtgtgtttt gatgaactat cttaccattt caccataggc tgaccacgtt
     3961 gctatagcca aaaatagcta aatacctcaa tcagtcccag aatgtcattt ttggtacttt
     4021 gctggccaca caagccatta ttcaccatgt gactagttgt gtcctgcagt ctgtatttaa
     4081 ctttctttta tgtctgtgga tttttccctt caaagttcaa taaatttatt ttcttgga
//
LOCUS       NM_001437844            2072 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus TEA domain transcription factor 2 (Tead2),
            transcript variant 1, mRNA.
ACCESSION   NM_001437844 XM_006229069
VERSION     NM_001437844.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Tamm,C., Bower,N. and Anneren,C.
  TITLE     Regulation of mouse embryonic stem cell self-renewal by a
            Yes-YAP-TEAD2 signaling pathway downstream of LIF
  JOURNAL   J Cell Sci 124 (Pt 7), 1136-1144 (2011)
   PUBMED   21385842
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Tian,W., Yu,J., Tomchick,D.R., Pan,D. and Luo,X.
  TITLE     Structural and functional analysis of the YAP-binding domain of
            human TEAD2
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7293-7298 (2010)
   PUBMED   20368466
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Bhattaram,P., Penzo-Mendez,A., Sock,E., Colmenares,C., Kaneko,K.J.,
            Vassilev,A., Depamphilis,M.L., Wegner,M. and Lefebvre,V.
  TITLE     Organogenesis relies on SoxC transcription factors for the survival
            of neural and mesenchymal progenitors
  JOURNAL   Nat Commun 1 (1), 9 (2010)
   PUBMED   20596238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Zhang,H., Liu,C.Y., Zha,Z.Y., Zhao,B., Yao,J., Zhao,S., Xiong,Y.,
            Lei,Q.Y. and Guan,K.L.
  TITLE     TEAD transcription factors mediate the function of TAZ in cell
            growth and epithelial-mesenchymal transition
  JOURNAL   J Biol Chem 284 (20), 13355-13362 (2009)
   PUBMED   19324877
  REMARK    Erratum:[J Biol Chem. 2019 Apr 12;294(15):5808. doi:
            10.1074/jbc.AAC119.008436. PMID: 30979850]
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Zhao,B., Ye,X., Yu,J., Li,L., Li,W., Li,S., Yu,J., Lin,J.D.,
            Wang,C.Y., Chinnaiyan,A.M., Lai,Z.C. and Guan,K.L.
  TITLE     TEAD mediates YAP-dependent gene induction and growth control
  JOURNAL   Genes Dev 22 (14), 1962-1971 (2008)
   PUBMED   18579750
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Sawada,A., Nishizaki,Y., Sato,H., Yada,Y., Nakayama,R.,
            Yamamoto,S., Nishioka,N., Kondoh,H. and Sasaki,H.
  TITLE     Tead proteins activate the Foxa2 enhancer in the node in
            cooperation with a second factor
  JOURNAL   Development 132 (21), 4719-4729 (2005)
   PUBMED   16207754
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Kaneko,K.J., Rein,T., Guo,Z.S., Latham,K. and DePamphilis,M.L.
  TITLE     DNA methylation may restrict but does not determine differential
            gene expression at the Sgy/Tead2 locus during mouse development
  JOURNAL   Mol Cell Biol 24 (5), 1968-1982 (2004)
   PUBMED   14966277
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Milewski,R.C., Chi,N.C., Li,J., Brown,C., Lu,M.M. and Epstein,J.A.
  TITLE     Identification of minimal enhancer elements sufficient for Pax3
            expression in neural crest and implication of Tead2 as a regulator
            of Pax3
  JOURNAL   Development 131 (4), 829-837 (2004)
   PUBMED   14736747
  REMARK    Erratum:[Development. 2004 Mar;131(5):1195]
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Yockey,C.E. and Shimizu,N.
  TITLE     cDNA cloning and characterization of mouse DTEF-1 and ETF, members
            of the TEA/ATTS family of transcription factors
  JOURNAL   DNA Cell Biol 17 (2), 187-196 (1998)
   PUBMED   9502435
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Yasunami,M., Suzuki,K., Houtani,T., Sugimoto,T. and Ohkubo,H.
  TITLE     Molecular characterization of cDNA encoding a novel protein related
            to transcriptional enhancer factor-1 from neural precursor cells
  JOURNAL   J Biol Chem 270 (31), 18649-18654 (1995)
   PUBMED   7629195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006229069.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168947.1, SRR22582416.735549.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  104838842-104838882
            42-279              JAXUCZ010000001.1  104840316-104840553
            280-344             JAXUCZ010000001.1  104841151-104841215
            345-407             JAXUCZ010000001.1  104842308-104842370
            408-515             JAXUCZ010000001.1  104843681-104843788
            516-574             JAXUCZ010000001.1  104843887-104843945
            575-639             JAXUCZ010000001.1  104846742-104846806
            640-782             JAXUCZ010000001.1  104848502-104848644
            783-956             JAXUCZ010000001.1  104851373-104851546
            957-1118            JAXUCZ010000001.1  104853338-104853499
            1119-1271           JAXUCZ010000001.1  104854158-104854310
            1272-2072           JAXUCZ010000001.1  104854835-104855635
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2072
                     /gene="Tead2"
                     /note="TEA domain transcription factor 2"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
     exon            1..41
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            42..279
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1385
                     /gene="Tead2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Embryonic TEA domain containing factor; TEA domain family
                     member 2; transcriptional enhancer factor TEF-4"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-4 isoform 1"
                     /protein_id="NP_001424773.1"
                     /db_xref="GeneID:308582"
                     /db_xref="RGD:1593252"
                     /translation="MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGV
                     WSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSS
                     HIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATEL
                     FQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPPATDLPGYEPPPALSPLPPPAPSPPAW
                     QARALGTARLQLVEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYD
                     KFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSGGAGGFYGVSSQYESR
                     ELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNFLHKLRQLP
                     ERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD"
     misc_feature    165..368
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    165..368
                     /gene="Tead2"
                     /note="TEA domain; Region: TEA; smart00426"
                     /db_xref="CDD:128703"
     misc_feature    726..1373
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     misc_feature    726..1373
                     /gene="Tead2"
                     /note="YAP binding domain; Region: YBD; pfam17725"
                     /db_xref="CDD:435993"
     exon            280..344
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..515
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..574
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..639
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..782
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..956
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1118
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1271
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2072
                     /gene="Tead2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgccccgc ccgcccgcgg ctcccctgcc caggccggga ggcccagatg ggggatcccc
       61 ggactggggc ccccctggat gatggcgggg gctggacagg tagtgaggaa ggcagcgagg
      121 agggcactgg aggcagtgaa ggtgttggag gtgatgggag ccccgatgca gaaggtgtgt
      181 ggagccctga catcgagcag agttttcagg aggccctggc aatctaccct ccctgtggcc
      241 gtcgcaagat catcttgtca gatgagggca agatgtatgg ccggaacgaa ctcatcgccc
      301 gttacatcaa gctgaggaca gggaagacca gaactcgaaa gcaggtctct agtcacatcc
      361 aggttttggc tcgaaggaaa tcgagagaaa ttcagtccaa gctgaaggac caagtctcca
      421 aggacaaggc cttccagacg atggccacca tgtcttcggc acagctcatc tctgcacctt
      481 ctctccaggc caagctgggt ccttctggcc ctcaggccac cgagcttttc cagttctggt
      541 cagggagctc tgggccaaca tggaatgttc cagacgtgaa gcccttctca caagcaccgt
      601 tctccatgtc actgacgccc ccagccactg acctaccagg gtacgagccg cccccagccc
      661 tctcacccct acccccaccc gccccatctc ccccagcctg gcaggctcgg gccctgggca
      721 ctgcgcgcct gcagctggta gagttctcag cgtttgtgga gccgccagat gcagttgact
      781 cgttccagag gcatctgttt gtccacatca gtcagcagtg ccccagccct ggagccccac
      841 ccctggagag tgtggacgtg cggcagatct acgacaaatt ccctgagaaa aagggcggtc
      901 tccgggagct gtatgaccgg gggccaccac atgccttttt cctggtcaag ttctgggcgg
      961 acctgaactg gggcccaagt gccgaggagg cagggaacag cggaggtgct ggtggcttct
     1021 acggagtgag cagccagtac gagagccgag agctcatgac actgacctgc tcctccaagg
     1081 tctgctcctt tggcaagcaa gtggtggaga aggtggagac agagcgggcc cagctggagg
     1141 gcgggcgctt tgtgtaccgc ctgctgcgct ctcccatgtg tgagtacctg gtcaacttcc
     1201 tgcacaagct ccgtcagctg cctgagcgct acatgatgaa cagcgtcctg gagaacttca
     1261 ccatcctcca ggttgtgaca aatagggaca ctcaggaact gctgctgtgt actgcctacg
     1321 tctttgaagt ctccaccagt gaacgcggag cccagcacca catctaccgc ctggtcaggg
     1381 actgatgggg ccccattgct gctgtttatc cgaacacccc cttcctagga agggcccttc
     1441 tgctctccct gtaagagaga tgtggagagg ggcccatgat ttttaaaaag gcctcatctc
     1501 agaagcaatg ggggctggct tctattagaa aggcacccga agcttggcag cgaagggagc
     1561 tgggtttgag tttagatccc caacacgagg acctcacaga gaacctttga caggacacac
     1621 cactcctgag catcagggat tgaggatagg agtgcatgcg cacaggtacg cggcctctcc
     1681 actctacagg ggcccctcct tgctcttctg gaaaggggag ctcagctatg tggggcctct
     1741 tactcattgc cttataccct tcctgttttc cagtggtctc atgtctgccc ctcccccaca
     1801 ccctttctct gggatctgta atgttacaaa ccgaagataa tggtttccca gcttgaggta
     1861 gagtgaagtg ggacctgaaa aattgtttta atataaggag atatttatac acagtgttag
     1921 ggatgtaatc ttatctcagc taggcagtgg ggtgggactt cttaatctcc ccccacccca
     1981 ttcaagtgag ccgtggacca ccctgccacc ttcccttccc caagagtgat ggtttatgtt
     2041 tgaaggagaa taaaactatt tttaccaaaa aa
//
LOCUS       NM_001437620            5721 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus SNF2 related chromatin remodeling ATPase 5
            (Smarca5), transcript variant 1, mRNA.
ACCESSION   NM_001437620 XM_063278020
VERSION     NM_001437620.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5721)
  AUTHORS   Thompson,P.J., Norton,K.A., Niri,F.H., Dawe,C.E. and McDermid,H.E.
  TITLE     CECR2 is involved in spermatogenesis and forms a complex with SNF2H
            in the testis
  JOURNAL   J Mol Biol 415 (5), 793-806 (2012)
   PUBMED   22154806
REFERENCE   2  (bases 1 to 5721)
  AUTHORS   Hargreaves,D.C. and Crabtree,G.R.
  TITLE     ATP-dependent chromatin remodeling: genetics, genomics and
            mechanisms
  JOURNAL   Cell Res 21 (3), 396-420 (2011)
   PUBMED   21358755
  REMARK    Review article
REFERENCE   3  (bases 1 to 5721)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   4  (bases 1 to 5721)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 5721)
  AUTHORS   Torres-Padilla,M.E. and Zernicka-Goetz,M.
  TITLE     Role of TIF1alpha as a modulator of embryonic transcription in the
            mouse zygote
  JOURNAL   J Cell Biol 174 (3), 329-338 (2006)
   PUBMED   16880268
REFERENCE   6  (bases 1 to 5721)
  AUTHORS   Loyola,A., Huang,J.Y., LeRoy,G., Hu,S., Wang,Y.H., Donnelly,R.J.,
            Lane,W.S., Lee,S.C. and Reinberg,D.
  TITLE     Functional analysis of the subunits of the chromatin assembly
            factor RSF
  JOURNAL   Mol Cell Biol 23 (19), 6759-6768 (2003)
   PUBMED   12972596
REFERENCE   7  (bases 1 to 5721)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   8  (bases 1 to 5721)
  AUTHORS   Loyola,A., LeRoy,G., Wang,Y.H. and Reinberg,D.
  TITLE     Reconstitution of recombinant chromatin establishes a requirement
            for histone-tail modifications during chromatin assembly and
            transcription
  JOURNAL   Genes Dev 15 (21), 2837-2851 (2001)
   PUBMED   11691835
REFERENCE   9  (bases 1 to 5721)
  AUTHORS   Strohner,R., Nemeth,A., Jansa,P., Hofmann-Rohrer,U., Santoro,R.,
            Langst,G. and Grummt,I.
  TITLE     NoRC--a novel member of mammalian ISWI-containing chromatin
            remodeling machines
  JOURNAL   EMBO J 20 (17), 4892-4900 (2001)
   PUBMED   11532953
REFERENCE   10 (bases 1 to 5721)
  AUTHORS   LeRoy,G., Orphanides,G., Lane,W.S. and Reinberg,D.
  TITLE     Requirement of RSF and FACT for transcription of chromatin
            templates in vitro
  JOURNAL   Science 282 (5395), 1900-1904 (1998)
   PUBMED   9836642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Apr 7, 2025 this sequence version replaced XM_063278020.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.79341.1,
                                           SRR26643297.51389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               JAXUCZ010000019.1  44175786-44176345
            561-635             JAXUCZ010000019.1  44178691-44178765
            636-802             JAXUCZ010000019.1  44181360-44181526
            803-903             JAXUCZ010000019.1  44182215-44182315
            904-1004            JAXUCZ010000019.1  44183677-44183777
            1005-1184           JAXUCZ010000019.1  44184438-44184617
            1185-1340           JAXUCZ010000019.1  44185866-44186021
            1341-1472           JAXUCZ010000019.1  44186102-44186233
            1473-1541           JAXUCZ010000019.1  44187975-44188043
            1542-1651           JAXUCZ010000019.1  44190928-44191037
            1652-1878           JAXUCZ010000019.1  44191756-44191982
            1879-2000           JAXUCZ010000019.1  44194140-44194261
            2001-2153           JAXUCZ010000019.1  44195118-44195270
            2154-2286           JAXUCZ010000019.1  44197152-44197284
            2287-2435           JAXUCZ010000019.1  44198993-44199141
            2436-2555           JAXUCZ010000019.1  44200120-44200239
            2556-2666           JAXUCZ010000019.1  44201159-44201269
            2667-2780           JAXUCZ010000019.1  44201522-44201635
            2781-2903           JAXUCZ010000019.1  44201951-44202073
            2904-3036           JAXUCZ010000019.1  44203584-44203716
            3037-3155           JAXUCZ010000019.1  44203833-44203951
            3156-3368           JAXUCZ010000019.1  44204342-44204554
            3369-5721           JAXUCZ010000019.1  44206608-44208960
FEATURES             Location/Qualifiers
     source          1..5721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..5721
                     /gene="Smarca5"
                     /note="SNF2 related chromatin remodeling ATPase 5"
                     /db_xref="GeneID:307766"
                     /db_xref="RGD:1308832"
     exon            1..560
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    372..374
                     /gene="Smarca5"
                     /note="upstream in-frame stop codon"
     CDS             387..3605
                     /gene="Smarca5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily A member 5; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily a, member 5"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A member
                     5 isoform 1"
                     /protein_id="NP_001424549.1"
                     /db_xref="GeneID:307766"
                     /db_xref="RGD:1308832"
                     /translation="MSSTAEPPPPPPPESAPSKPSAAGAGGSSSGNKGGPEGGAAPAA
                     PSATGAGPADTEMEEVFDDGSPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFA
                     HFIQPAAQKTPTSPLKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKA
                     TNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLL
                     GYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLP
                     GEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL
                     TGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLL
                     RRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILM
                     QLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMT
                     RVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGIN
                     LATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKL
                     RLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAK
                     KTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKAN
                     YAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYK
                     VPRSPDLPNAAQAQKEEQLKIDEAGPLNDEELEEKEKLLTQGFTNWNKRDFNQFIKAN
                     EKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRI
                     SIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDEL
                     RQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKPS
                     VSTDYVNHTVLGVLCTVVCMCMCVCIIHICMCSNTHCVGRRG"
     misc_feature    588..3419
                     /gene="Smarca5"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     misc_feature    588..3419
                     /gene="Smarca5"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional; Region: PLN03142"
                     /db_xref="CDD:215601"
     exon            561..635
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            636..802
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            803..903
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1004
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1184
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1340
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1472
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1541
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1651
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1878
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2000
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2153
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2286
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2435
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2555
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2666
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2780
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2903
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3036
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3155
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3368
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..5721
                     /gene="Smarca5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaagata atctactccg gtagaggaga aggcgccggg agacctctga gtacctttcg
       61 ctttcctttc cctttccctc ggccctccgc ctcctcacag tcagcccgcc ctccctgacc
      121 tccttgaccc cgctggcccc gcccaccctc gtcgacgtga ttcccgccgt gaggtaaacg
      181 ccagtggagc ggagtcccgc ggaagaggag gactaggcga gcgtcgcggc tgggccggct
      241 ctggtcggtg gcggagcccc tgcgcgtgag agcttccggg cgggtctcgc tcctccggcg
      301 gcccggacgc tagagccgcg caggcccagg ccgctttcct cggcgccgcg cctgcccgtg
      361 gccgcggcgg gtgacgcagc cggaacatgt cgtccacggc tgagcctccg ccgcccccgc
      421 ctcccgagag cgcgccttcc aagccctcgg cggcgggcgc cggcgggagc agcagcggca
      481 acaaaggcgg cccggagggc ggcgcggcgc cggcggctcc gagcgccaca ggcgcgggtc
      541 ccgcggacac cgagatggag gaagtatttg atgatggatc acctggaaag caaaaagaaa
      601 tccaagaacc tgatcctaca tatgaagaaa aaatgcaaac tgaccgagca aatagatttg
      661 agtatttatt aaagcagaca gagctgttcg cacatttcat tcagcctgct gctcagaaga
      721 ctccaacctc acccttgaag atgaaaccag ggcgcccacg ggtaaaaaag gatgaaaaac
      781 agaatttgct ttcggttgga gactaccgac atcgtagaac agagcaagag gaggatgaag
      841 agctattaac agaaagttcc aaagcaacca atgtttgtac tcgatttgaa gattctccat
      901 catatgtaaa atggggtaaa ctgagagatt atcaggtccg aggattgaat tggctcatct
      961 ctctgtatga gaatggcatc aatggtatcc ttgcagatga gatgggtttg ggaaagactc
     1021 tgcaaacaat ttctcttctt gggtacatga aacactatag aaatattcct ggtcctcata
     1081 tggttttggt tcccaagtct acattgcaca actggatgag tgaattcaag agatgggtgc
     1141 caacacttag gtctgtttgc ttgataggag ataaagagca aagagctgca tttgtcaggg
     1201 atgttctatt accaggagag tgggatgtat gtgtcacatc ttatgaaatg cttattaaag
     1261 agaagtctgt gttcaaaaaa tttaactgga gatacttagt tatagatgaa gctcacagga
     1321 taaaaaatga aaaatctaag ttgtcagaaa tagtgagaga attcaagact acaaaccgac
     1381 tgttgctgac agggacgcct cttcagaaca acctgcacga gctctggtcc ctgctaaact
     1441 ttttgttacc agatgtgttt aattcagctg atgactttga ttcctggttt gatacaaata
     1501 attgccttgg ggatcaaaaa ctagttgaga ggcttcatat ggttttgcgt ccattccttc
     1561 ttcgtcgaat taaagctgat gttgaaaaga gtttgcctcc aaagaaagaa gtaaaaatct
     1621 atgtgggtct tagcaaaatg caaagggaat ggtatactcg gatattaatg aaagacatag
     1681 acatactgaa ctcagcaggg aagatggaca agatgagact gttgaacatc ttgatgcagc
     1741 tgaggaagtg ctgtaaccac ccttatctct ttgacggggc tgagcctggg cctccctaca
     1801 ccacagatat gcatctggtt accaacagcg gcaagatggt ggtgttggac aaactgctcc
     1861 ctaaattaaa agaacaaggt tcaagagtac taatctttag tcagatgaca agggtattag
     1921 acattttgga agattattgc atgtggagaa attatgagta ctgcaggttg gatggacaga
     1981 caccccatga tgagagacaa gactccatta atgcatacaa tgaaccaaat agcaccaagt
     2041 ttgtatttat gctaagcaca cgtgctggtg gtctgggcat caaccttgca actgctgatg
     2101 tagtaatttt atatgattca gattggaatc ctcaagttga tcttcaggct atggaccgag
     2161 cacatagaat tggacaaacg aagactgttc gagtgttccg ctttataact gataacactg
     2221 tggaagaaag aatagtagaa cgtgccgaga tgaagctcag actggattcc atcgtaattc
     2281 aacaagggag gcttgtagat cagaacctga acaaaattgg gaaagatgaa atgcttcaaa
     2341 tgattcgaca tggtgccaca catgtgtttg cttcaaaaga aagtgaaatc actgatgagg
     2401 atattgatgg tattttggaa agaggtgcaa agaagactgc agaaatgaat gaaaagctct
     2461 ccaagatggg tgaaagctca cttagaaact ttacgatgga tacagagtcc agtgtttata
     2521 actttgaagg agaagactat agagaaaaac aaaagattgc attcacagag tggattgaac
     2581 cacctaagag agaaagaaaa gccaactatg ctgtagatgc gtacttcagg gaagctctgc
     2641 gtgtcagtga gcctaaagca cccaaggcgc ctcgacctcc aaaacaacca aatgttcagg
     2701 atttccagtt ctttcctcca cgtttatttg aattactgga aaaagaaatt ctatattaca
     2761 ggaaaactat cggttacaag gtacctcgga gtcctgatct acccaatgca gcacaggcac
     2821 agaaggaaga gcagcttaaa atcgacgaag cagggcccct taatgacgag gagttagagg
     2881 aaaaagagaa gcttctgact caggggttca ctaattggaa taagagagat tttaaccagt
     2941 ttatcaaggc taatgaaaag tggggtcgcg atgatattga gaacatagcc agagaagtag
     3001 aagggaaaac tccagaagaa gtcattgagt actcagctgt gttctgggaa agatgcaatg
     3061 agctccagga catagagaag attatggctc agattgaaag gggagaggca aggattcaaa
     3121 gaagaataag tatcaagaaa gcactagata caaagattgg acggtacaaa gcaccctttc
     3181 accaactaag aatatcgtat ggtactaaca aagggaaaaa ctacacggaa gaagaggacc
     3241 gctttctcat ttgtatgctt cacaagcttg gcttcgacaa ggaaaatgtt tatgatgagt
     3301 tacgacaatg catccgaaac tcccctcagt tcagatttga ttggtttctc aagtccagaa
     3361 ctgcgatgga gctccagagg aggtgtaata ccttaattac tttgattgaa agggaaaata
     3421 tggaactaga agaaaaggag aaggcagaga aaaagaaaag aggaccaaag ccttccgtga
     3481 gtacagatta tgtgaatcat acagttttgg gtgttttatg cacagtagtg tgtatgtgca
     3541 tgtgtgtgtg tattatccat atatgtatgt gtagtaatac tcactgtgtg gggcgcagag
     3601 gttgacaatc agatgcccct ttattttttg attaaagagt cacactgaat ttgcagcttg
     3661 ccattttgct aggtaggctg ttgtaagcaa ctcttctttt ccagacccat gcaccatcat
     3721 tgggttttag gattttactg gatttgggga tcagagctca ggcccttaga cttgcatgac
     3781 aagcagttta cccaccagcc atttgtcccg caaacccacc acaaccaact tttaaagtat
     3841 ttgaacattg ttttgttttt cctttgtaaa taatacattt gagttgcctt aaaatataaa
     3901 ctgggtttga tacactaaat atagaaaacc atgttactct gaggagctaa aagaaactct
     3961 tctgattgcc aaaagtactc acttgttctt gagaatgctt gaaattttag gagactttta
     4021 aggagtatta gaatattgaa catggtggct tgacaagttc tatggcagtc ttctaagttt
     4081 ttttttttta aaggtttatt tattttatat atatgagtac actgtagccg tcttcaaaca
     4141 caccagaaga ggacatcaga tcccattaca gatggttgtg agccaccatg tggttgctgg
     4201 aaattgaact caggacctct ggaagagcag tcagtgctct taaccactga gccatcgctc
     4261 cagcccccgt cttctaagct ttgatttaag tttagtttga ttctaagttt gattctaagt
     4321 ttagtactgt gttagtttga atgtaaatat ttcaggagga aataggcatc ctgttagtca
     4381 gcagcagtaa attatttgga gatttgatag tagttttgaa agatttgtta tgaagccctg
     4441 cagaagagtc ttaggctgtc agtcatatgc agtcactgct accatgctgc atcatgtttg
     4501 agaactaatt gttctgtttg tttatagaca cagaaacgta agatggatgg tgcccctgat
     4561 ggccgaggaa gaaaaaagaa gctgaaacta tgaatgcgtt ttgtcttata atcactaact
     4621 agtagttctt taatttacgg gtcttcataa gatgttctgt acagtgctca actgttactg
     4681 tcattcagag acatgaggtc atctgcttac tgagctagaa acatagtatg tagtttccct
     4741 tttttaaatg caacagctgt gctgaaattt tttttatcat taacaattga agtaataaaa
     4801 caggcttcat ttattaataa atgtttcatt tgatttattt ttctaatagt ttcatttgtg
     4861 aggattgtgg ctttttatca gctactttaa cacttgtatg gcttaaaaac aagcaaacaa
     4921 gtaaaaaaaa aaaatgcaaa taacatttga ttggtccctt ctacctggtt tgtaattact
     4981 tcacattctt tgctgatttt tttttttttt ttttttttgg tagtactatt gagtctcatc
     5041 tggaaagatt gtgtaaattg cattcttgct tattatagaa tgggggtaag gcaagacata
     5101 ttaattttct gtgcatattt ctgttacact ttctgtttct atggttctga tgtgaatgtg
     5161 ccctattttg ttggatgaat ggcctttttt agttgtatag ccaaagacat ttagtatttt
     5221 ctggttcttt aaggtaatgt attattttgt aaaaggaatt tttttaagta tttggaaaat
     5281 attttgacaa atggcctgca gcagccacaa cttagaaaga taatgtcaga agtgaggtga
     5341 tttttttttt taatttgaat gaccaagcca aaatgaggtg agaatttgtc atactgttat
     5401 aatactaata gaatgtaccc tctcagttta tagtattttt tgagttttta gagtaaatga
     5461 aaattttatt ttattatatt ttacaaataa cttctaagtc ttagtagcaa gatggagtat
     5521 aattccagtt tttattttct atggaataga ctggtgaact ggagaccttg aagcaggaat
     5581 acccagaggc ctttatgtgc tacacatcat ttgtataaag ttttatatgt gcaaattggg
     5641 tacataagca gttctccatt tttctaaggg aatgcaataa atgtagcatc gtgaataaat
     5701 ataactttta taatccttaa a
//
LOCUS       NM_001437888            2321 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus pre-mRNA processing factor 3 (Prpf3), transcript
            variant 2, mRNA.
ACCESSION   NM_001437888 XM_063282172
VERSION     NM_001437888.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Long,S.W., Ooi,J.Y., Yau,P.M. and Jones,P.L.
  TITLE     A brain-derived MeCP2 complex supports a role for MeCP2 in RNA
            processing
  JOURNAL   Biosci Rep 31 (5), 333-343 (2011)
   PUBMED   21070191
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J.,
            Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.
  TITLE     The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control
            reversible ubiquitination at the spliceosome
  JOURNAL   Genes Dev 24 (13), 1434-1447 (2010)
   PUBMED   20595234
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   Schaffert,N., Hossbach,M., Heintzmann,R., Achsel,T. and Luhrmann,R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Chakarova,C.F., Hims,M.M., Bolz,H., Abu-Safieh,L., Patel,R.J.,
            Papaioannou,M.G., Inglehearn,C.F., Keen,T.J., Willis,C.,
            Moore,A.T., Rosenberg,T., Webster,A.R., Bird,A.C., Gal,A., Hunt,D.,
            Vithana,E.N. and Bhattacharya,S.S.
  TITLE     Mutations in HPRP3, a third member of pre-mRNA splicing factor
            genes, implicated in autosomal dominant retinitis pigmentosa
  JOURNAL   Hum Mol Genet 11 (1), 87-92 (2002)
   PUBMED   11773002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_063282172.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.9892.1,
                                           SRR26643299.11032.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000002.1  186092318-186092355 c
            39-231              JAXUCZ010000002.1  186089948-186090140 c
            232-362             JAXUCZ010000002.1  186087902-186088032 c
            363-509             JAXUCZ010000002.1  186085129-186085275 c
            510-593             JAXUCZ010000002.1  186083966-186084049 c
            594-814             JAXUCZ010000002.1  186083585-186083805 c
            815-1121            JAXUCZ010000002.1  186081114-186081420 c
            1122-1288           JAXUCZ010000002.1  186080368-186080534 c
            1289-1368           JAXUCZ010000002.1  186077517-186077596 c
            1369-1512           JAXUCZ010000002.1  186074038-186074181 c
            1513-1612           JAXUCZ010000002.1  186073378-186073477 c
            1613-1726           JAXUCZ010000002.1  186073061-186073174 c
            1727-1845           JAXUCZ010000002.1  186071606-186071724 c
            1846-1929           JAXUCZ010000002.1  186071281-186071364 c
            1930-1991           JAXUCZ010000002.1  186069908-186069969 c
            1992-2321           JAXUCZ010000002.1  186067980-186068309 c
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2321
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
     exon            1..38
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            39..231
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Prpf3"
                     /note="upstream in-frame stop codon"
     CDS             87..2138
                     /gene="Prpf3"
                     /note="isoform 2 is encoded by transcript variant 2; U4/U6
                     small nuclear ribonucleoprotein Prp3; PRP3 pre-mRNA
                     processing factor 3 homolog"
                     /codon_start=1
                     /product="U4/U6 small nuclear ribonucleoprotein Prp3
                     isoform 2"
                     /protein_id="NP_001424817.1"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
                     /translation="MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDK
                     KKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEIS
                     KESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQL
                     SFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLA
                     LKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTH
                     RMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGK
                     FEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDS
                     YIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR
                     QTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQ
                     KAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQ
                     LYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAV
                     KKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLEST
                     D"
     misc_feature    93..305
                     /gene="Prpf3"
                     /note="domain in splicing factors; Region: PWI;
                     smart00311"
                     /db_xref="CDD:214609"
     misc_feature    93..305
                     /gene="Prpf3"
                     /note="domain in splicing factors; Region: PWI;
                     smart00311"
                     /db_xref="CDD:214609"
     misc_feature    1008..1649
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3 (PRP3); Region: PRP3;
                     pfam08572"
                     /db_xref="CDD:462524"
     misc_feature    1008..1649
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3 (PRP3); Region: PRP3;
                     pfam08572"
                     /db_xref="CDD:462524"
     misc_feature    1716..2105
                     /gene="Prpf3"
                     /note="Protein of unknown function (DUF1115); Region:
                     DUF1115; pfam06544"
                     /db_xref="CDD:461943"
     misc_feature    1716..2105
                     /gene="Prpf3"
                     /note="Protein of unknown function (DUF1115); Region:
                     DUF1115; pfam06544"
                     /db_xref="CDD:461943"
     exon            232..362
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..509
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..593
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..814
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1121
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1288
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1368
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1512
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1612
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1726
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1845
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1929
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1991
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2321
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgttcggg ctccgtctca ggggctgaag tttgtgaggt gtagtacttt gtccgatttg
       61 agctcttagt ctctgtttcc tccaaaatgg cactgtctaa gcgggaactg gatgagctga
      121 aaccatggat agagaagaca gtgaagagag tgctgggttt ctcagagccc acggtggtca
      181 cagcggcatt gaactgtgtg gggaagggca tggacaaaaa gaaggcggct gatcacctga
      241 aaccttttct tgatgactcc actctccgat ttgtggataa gttgtttgaa gctgtggagg
      301 aaggccggag ctcaagacac tccaagtcta gcagtgacag aagcaggaaa cgagagttaa
      361 aggaggtgtt tggtgatgac tctgagatct caaaggaatc atcaggggta aagaagcggc
      421 gaataccccg ttttgaggag gtagaagagg aaccagaggt gatccctgga cctccgtcag
      481 aaagccctgg catgctaacg aagctccaga tcaaacagat gatggaggca gcaacgagac
      541 aaatcgagga aaggaaaaag cagctgagct tcatcagccc ccctgcacct cagccaaaga
      601 caccttcttc ttcccaacca gagcgacttc caattggcaa cactattcag ccctcccagg
      661 ccgctacctt tatgaatgat gccattgaga aggcaaggaa agccgctgaa ctacaagccc
      721 gaatccaggc ccagctggct ttgaagccag ggcttattgg caatgccaac atggtgggcc
      781 tagctaatct ccatgccatg ggcatagctc caccgaaagt cgagttaaaa gatcagacga
      841 agcccacccc actgatcctg gatgagcaag gccgcactgt ggatgccaca ggcaaggagg
      901 tggagctcac acaccgcatg cccaccctga aggcaaacat tcgagctgtg aagagggaac
      961 agttcaaaca gcaactaaaa gaaaagccat cagaagacat ggaatctaat accttttttg
     1021 accccagagt ctcaattgcc ccttcccagc gtcaaagacg cacttttaaa ttccatgaca
     1081 agggcaaatt tgagaagatt gctcaacgat tacggacaaa ggctcagttg gaaaagctgc
     1141 aagcagagat ttcacaggct gctagaaaaa caggcattca tacgtcgact agacttgccc
     1201 tcattgctcc taaaaaagag ctgaaggaag gcgacatccc tgaaattgag tggtgggact
     1261 cctacatcat tcccaatggc tttgacctta cagaggaaaa tcccaagaga gaagattatt
     1321 ttggaatcac aaatcttgtt gaacatccag cccagcttaa ccctccagtt gacaatgaca
     1381 caccagttac cctgggtgtg tatcttacaa agaaggagca gaagaaactt cggaggcaaa
     1441 caaggaggga ggcacagaag gagctacagg agaaagtcag gctaggcctg acacctcctc
     1501 cagagcccaa agtgaggatc tccaatttaa tgcgagtatt aggaacagaa gcagttcaag
     1561 accctacaaa ggtagaagcc cacgtcagag ctcagatggc aaagagacag aaagcgcacg
     1621 aagaggccaa cgctgcccga aaacttacag cagaacagag aaaggtcaag aaagttaaaa
     1681 agcttaaaga agacatttca cagggggtgc acatatctgt gtatagagtt cgaaatttga
     1741 gcaacccagc caagaagttc aagatcgagg ccaatgctgg gcagctgtac ctgacggggg
     1801 tggtagtgct gcacaaggat gtcaacgtgg tggtcgtgga agggggcccc aaagcccaga
     1861 agaaatttaa gcgtctcatg ctacatcgga taaagtggga tgagcagacg tctaacacga
     1921 agggagatga tgatgaggaa tctgatgaag aagctgtgaa gaaaactaac aaatgtgtac
     1981 tagtgtggga gggcacagcc aaagaccgga gctttggaga gatgaagttc aaacagtgcc
     2041 ctacagagaa catggcgcgt gagcatttca agaagcacgg ggctgagcac tactgggacc
     2101 ttgccctgag tgaatctgtg ctggagtcca ccgactgaga cgactgctag ccttgtgtct
     2161 tcttctcact ctgcttccca accttaccca actgtgcgtg tgatctcaga accgtgccag
     2221 gctgatactg gggcaaagag actaccaagt tcacccagtc agcctggtgc tacccttcct
     2281 cctgtatgtg catatgatta aagagttatt tttaaaatta g
//
LOCUS       NM_001437887             795 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus CART prepropeptide (Cartpt), transcript variant
            2, mRNA.
ACCESSION   NM_001437887 XM_006231843
VERSION     NM_001437887.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Casini,A., Vivacqua,G., Vaccaro,R., Renzi,A., Leone,S.,
            Pannarale,L., Franchitto,A., Onori,P., Mancinelli,R. and Gaudio,E.
  TITLE     Expression and role of cocaine-amphetamine regulated transcript
            (CART) in the proliferation of biliary epithelium
  JOURNAL   Eur J Histochem 67 (4), 3846 (2023)
   PUBMED   37859350
  REMARK    GeneRIF: Expression and role of cocaine-amphetamine regulated
            transcript (CART) in the proliferation of biliary epithelium.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Schuller,J. and Koch,M.
  TITLE     Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats
  JOURNAL   Behav Brain Res 440, 114268 (2023)
   PUBMED   36539163
  REMARK    GeneRIF: Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats.
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Samson,W.K., Salvemini,D. and Yosten,G.L.C.
  TITLE     Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise
  JOURNAL   Endocrinology 162 (8) (2021)
   PUBMED   34043767
  REMARK    GeneRIF: Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise.
            Review article
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Drott,C.J., Norman,D. and Espes,D.
  TITLE     CART decreases islet blood flow, but has no effect on total
            pancreatic blood flow and glucose tolerance in anesthetized rats
  JOURNAL   Peptides 135, 170431 (2021)
   PUBMED   33098940
  REMARK    GeneRIF: CART decreases islet blood flow, but has no effect on
            total pancreatic blood flow and glucose tolerance in anesthetized
            rats.
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Walker,L.C., Hand,L.J., Letherby,B., Huckstep,K.L., Campbell,E.J.
            and Lawrence,A.J.
  TITLE     Cocaine and amphetamine regulated transcript (CART) signalling in
            the central nucleus of the amygdala modulates stress-induced
            alcohol seeking
  JOURNAL   Neuropsychopharmacology 46 (2), 325-333 (2021)
   PUBMED   32826981
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Walder,K., Morris,C. and Ravussin,E.
  TITLE     A polymorphism in the gene encoding CART is not associated with
            obesity in Pima Indians
  JOURNAL   Int J Obes Relat Metab Disord 24 (4), 520-521 (2000)
   PUBMED   10805512
REFERENCE   7  (bases 1 to 795)
  AUTHORS   Echwald,S.M., Sorensen,T.I., Andersen,T., Hansen,C., Tommerup,N.
            and Pedersen,O.
  TITLE     Sequence variants in the human cocaine and amphetamine-regulated
            transcript (CART) gene in subjects with early onset obesity
  JOURNAL   Obes Res 7 (6), 532-536 (1999)
   PUBMED   10574510
REFERENCE   8  (bases 1 to 795)
  AUTHORS   Thim,L., Nielsen,P.F., Judge,M.E., Andersen,A.S., Diers,I.,
            Egel-Mitani,M. and Hastrup,S.
  TITLE     Purification and characterisation of a new hypothalamic satiety
            peptide, cocaine and amphetamine regulated transcript (CART),
            produced in yeast
  JOURNAL   FEBS Lett 428 (3), 263-268 (1998)
   PUBMED   9654146
REFERENCE   9  (bases 1 to 795)
  AUTHORS   Kristensen,P., Judge,M.E., Thim,L., Ribel,U., Christjansen,K.N.,
            Wulff,B.S., Clausen,J.T., Jensen,P.B., Madsen,O.D., Vrang,N.,
            Larsen,P.J. and Hastrup,S.
  TITLE     Hypothalamic CART is a new anorectic peptide regulated by leptin
  JOURNAL   Nature 393 (6680), 72-76 (1998)
   PUBMED   9590691
REFERENCE   10 (bases 1 to 795)
  AUTHORS   Douglass,J., McKinzie,A.A. and Couceyro,P.
  TITLE     PCR differential display identifies a rat brain mRNA that is
            transcriptionally regulated by cocaine and amphetamine
  JOURNAL   J Neurosci 15 (3 Pt 2), 2471-2481 (1995)
   PUBMED   7891182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006231843.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.5470.1, CB733430.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000002.1  32991058-32991235   c
            179-262             JAXUCZ010000002.1  32990546-32990629   c
            263-795             JAXUCZ010000002.1  32989221-32989753   c
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..795
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="CART prepropeptide"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
     exon            1..178
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..370
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cocaine and amphetamine regulated transcript;
                     cocaine- and amphetamine-regulated transcript protein"
                     /codon_start=1
                     /product="cocaine- and amphetamine-regulated transcript
                     protein isoform 2 precursor"
                     /protein_id="NP_001424816.1"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
                     /translation="MESSRLRLLPVLGAALLLLLPLLGAGAQEDAELQPRALDIYSAV
                     DDASHEKELIEALQEVLKKLKSKRIPIYEKKYGQVPMCDAGEQCAVRKGARIGKLCDC
                     PRGTSCNSFLLKCL"
     sig_peptide     20..100
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    161..367
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Cocaine and amphetamine regulated transcript
                     protein (CART); Region: CART; pfam06373"
                     /db_xref="CDD:461888"
     misc_feature    161..367
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="Cocaine and amphetamine regulated transcript
                     protein (CART); Region: CART; pfam06373"
                     /db_xref="CDD:461888"
     exon            179..262
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     exon            263..795
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggaag tccagcacca tggagagctc ccgcctgcgg ctgctacccg tcctgggcgc
       61 cgccctactg ctgctgctac ctttgctggg tgccggtgcc caggaggatg ccgagctgca
      121 gccccgagcc ctggacatct actctgccgt ggatgatgcg tcccatgaga aggagctgat
      181 tgaagcgctg caggaagtcc tgaagaagct caagagtaaa cgcattccga tctatgagaa
      241 gaagtacggc caagtcccca tgtgtgacgc tggagagcag tgcgcagtgc ggaaaggggc
      301 caggatcggg aagctgtgtg actgtccccg aggaacttct tgcaattctt tcctcttgaa
      361 gtgcttgtga aggggtgaca gcctccttcg gttcccatat ttcctctttc ccctaaagga
      421 gcgctctttt gtccctggag ccgctttaac aacaataaag tttgcgttcc ccccagagag
      481 tggatgggct ctttccctgc tgcttcaaaa taaaagattt gatgttattg tgtgaaggac
      541 aataccttga atggtgttgg tatgtgtgca aagtattctt ctctcgtttt atccacctga
      601 cacattcttg tgacctttct gggaagaaga gggactttcg ctttaaaact gtatttttgt
      661 atgtggcggg tcacaatgaa gattagacct agttaatttt ggcagatgac atcataaccc
      721 ggaaaacaaa tcaccccaaa gcaacacaaa tggaagcgtg tgcaaattac acccaataaa
      781 gcatttttga taatt
//
LOCUS       NM_001034111            9448 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus prolactin receptor (Prlr), transcript variant 1,
            mRNA.
ACCESSION   NM_001034111
VERSION     NM_001034111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9448)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   2  (bases 1 to 9448)
  AUTHORS   Vergara-Castaneda,E., Grattan,D.R., Pasantes-Morales,H.,
            Perez-Dominguez,M., Cabrera-Reyes,E.A., Morales,T. and Cerbon,M.
  TITLE     Prolactin mediates neuroprotection against excitotoxicity in
            primary cell cultures of hippocampal neurons via its receptor
  JOURNAL   Brain Res 1636, 193-199 (2016)
   PUBMED   26874070
  REMARK    GeneRIF: This study demonstrated that the Cultured neurons
            expressed mRNA for both PRL and its receptor (PRLR), and both PRL
            and PRLR expression levels changed after the excitotoxic insult.
REFERENCE   3  (bases 1 to 9448)
  AUTHORS   Rojas-Duran,F., Pascual-Mathey,L.I., Serrano,K., Aranda-Abreu,G.E.,
            Manzo,J., Soto-Cid,A.H. and Hernandez,M.E.
  TITLE     Correlation of prolactin levels and PRL-receptor expression with
            Stat and Mapk cell signaling in the prostate of long-term sexually
            active rats
  JOURNAL   Physiol Behav 138, 188-192 (2015)
   PUBMED   25446202
  REMARK    GeneRIF: Results showed that an active sexual life, with constant
            execution of sexual behavior, produces a sustained increase in
            serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
REFERENCE   4  (bases 1 to 9448)
  AUTHORS   Arumugam,R., Fleenor,D. and Freemark,M.
  TITLE     Knockdown of prolactin receptors in a pancreatic beta cell line:
            effects on DNA synthesis, apoptosis, and gene expression
  JOURNAL   Endocrine 46 (3), 568-576 (2014)
   PUBMED   24114406
  REMARK    GeneRIF: PRLR signaling is required for DNA synthesis and survival
            of rat insulinoma cells
REFERENCE   5  (bases 1 to 9448)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 9448)
  AUTHORS   Ali,S., Pellegrini,I. and Kelly,P.A.
  TITLE     A prolactin-dependent immune cell line (Nb2) expresses a mutant
            form of prolactin receptor
  JOURNAL   J Biol Chem 266 (30), 20110-20117 (1991)
   PUBMED   1718958
REFERENCE   7  (bases 1 to 9448)
  AUTHORS   Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.M.,
            Edery,M., Djiane,J. and Kelly,P.A.
  TITLE     Expression of two forms of prolactin receptor in rat ovary and
            liver
  JOURNAL   Mol Endocrinol 4 (8), 1136-1143 (1990)
   PUBMED   2293022
REFERENCE   8  (bases 1 to 9448)
  AUTHORS   Zhang,R., Buczko,E., Tsai-Morris,C.H., Hu,Z.Z. and Dufau,M.L.
  TITLE     Isolation and characterization of two novel rat ovarian lactogen
            receptor cDNA species
  JOURNAL   Biochem Biophys Res Commun 168 (2), 415-422 (1990)
   PUBMED   2159291
REFERENCE   9  (bases 1 to 9448)
  AUTHORS   Boutin,J.M., Jolicoeur,C., Okamura,H., Gagnon,J., Edery,M.,
            Shirota,M., Banville,D., Dusanter-Fourt,I., Djiane,J. and
            Kelly,P.A.
  TITLE     Cloning and expression of the rat prolactin receptor, a member of
            the growth hormone/prolactin receptor gene family
  JOURNAL   Cell 53 (1), 69-77 (1988)
   PUBMED   2832068
REFERENCE   10 (bases 1 to 9448)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001034111.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57668.1, SRR26643297.6937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000002.1  60861658-60861882
            226-248             JAXUCZ010000002.1  60992578-60992600
            249-358             JAXUCZ010000002.1  61012956-61013065
            359-491             JAXUCZ010000002.1  61016362-61016494
            492-661             JAXUCZ010000002.1  61018046-61018215
            662-831             JAXUCZ010000002.1  61027952-61028121
            832-973             JAXUCZ010000002.1  61029594-61029735
            974-1073            JAXUCZ010000002.1  61030181-61030280
            1074-1143           JAXUCZ010000002.1  61030794-61030863
            1144-9448           JAXUCZ010000002.1  61032628-61040932
FEATURES             Location/Qualifiers
     source          1..9448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..9448
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
     exon            1..225
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            226..248
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            249..358
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    271..273
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="upstream in-frame stop codon"
     CDS             304..2136
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; PRL-R; lactogen receptor"
                     /codon_start=1
                     /product="prolactin receptor isoform a precursor"
                     /protein_id="NP_001029283.2"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
                     /translation="MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     QMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFT
                     MEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESS
                     VEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVK
                     PTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQ
                     STNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVL
                     KLSKALETGEEEVAEQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDG
                     VLSLFPKQRENNQTEKPGVPETSKEYAKVSGITDNNILVLVPDSRAQNTALLEESAKK
                     APPSFEADQSEKDLASFTATSSNRRLQLGRLDYLDPTCFMHSFH"
     sig_peptide     304..417
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
     misc_feature    358..648
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     misc_feature    358..648
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cl21522"
                     /db_xref="CDD:473895"
     mat_peptide     418..2133
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /product="prolactin receptor isoform a"
     misc_feature    463..465
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    598..600
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    667..960
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    667..960
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:238020"
     misc_feature    order(667..669,880..882,925..927)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(667..669,880..882,925..927)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    682..684
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P05710.2); glycosylation site"
     misc_feature    931..945
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: WSXWS motif"
     misc_feature    order(931..936,940..945)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(931..936,940..945)
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    991..1062
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     transmembrane region"
     misc_feature    1087..1113
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Box 1 motif"
     misc_feature    1252..1368
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1675..1749
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1993..2055
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="propagated from UniProtKB/Swiss-Prot (P05710.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            359..491
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            492..661
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            662..831
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            832..973
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1073
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1143
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..9448
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacacgc ggctggcgac tgcggagcag aggctaaaat ccccagacgc cgggtcttct
       61 gggctgggct ttccccgcct tcctgctctg tctcactcgc tcctctcctg cgttctggat
      121 tttacacggg gctcaggaaa cagctttacc tgtcagagac agagctcacg tcctttgcag
      181 gaagtgcaca gcctctggta tggcagactt ttctctccag cagaactaaa ggacacttct
      241 ctgtgaaggg agcctctgat acattgccta tagcaagaag aaggggccaa cctgaagaaa
      301 aacatgccat ctgcacttgc tttcgtccta cttgttctca acatcagcct cctgaaggga
      361 cagtcaccac cagggaaacc tgagatccac aaatgtcgct ctcctgacaa ggaaacattc
      421 acctgctggt ggaatcctgg gacagatgga ggacttccta ccaattattc actgacttac
      481 agcaaagaag gagagaaaac cacctacgaa tgtccagact acaaaaccag cggccccaac
      541 tcctgcttct ttagcaagca gtacacttcc atctggaaaa tatatatcat cacagtaaat
      601 gccacgaacc aaatgggaag cagttcctcg gatccacttt atgtggatgt gacttacatc
      661 gttgagccag agcctcctcg gaacctgaca ttagaagtaa aacagctaaa agacaaaaaa
      721 acatatctgt gggtaaaatg gtccccaccc accataactg atgtgaaaac tggttggttt
      781 acaatggaat atgaaattcg attaaagcct gaagaagcag aagagtggga gatccatttt
      841 acaggtcatc aaacacagtt taaagttttt gacctatatc cagggcaaaa gtatcttgtc
      901 cagactcgct gcaagccaga ccatggatac tggagtagat ggagccagga gagttccgtt
      961 gaaatgccaa atgacttcac cttgaaggac acaaccgtgt ggatcattgt ggccattctc
     1021 tctgctgtca tctgtttgat tatggtctgg gcagtggctt tgaagggcta tagcatgatg
     1081 acctgcatct ttccaccagt tcctgggcca aaaataaaag gatttgatac ccatctgctg
     1141 gagaagggca agtctgaaga gctgctgagt gccttggggt gccaagactt tccccctact
     1201 tctgactgtg aggacttgct ggtggagttc ttagaagttg atgacaatga ggacgagcgg
     1261 ctaatgccat cccattccaa agagtatcca ggtcagggtg ttaagcccac acacctagat
     1321 cccgacagtg actctggtca cggaagctat gacagccatt ctcttttatc tgaaaagtgt
     1381 gaggaacccc aggcctaccc ccctactttg cacatccctg agatcactga gaagccagag
     1441 aatcctgaag caaatattcc tcccaccgtg gacccccaaa gcaccaaccc caattttcat
     1501 gtagatgcac ccaaatcttc aacatggcca ttactgcctg gccaacacat gcccagatct
     1561 ccttaccaca gtgttgctga tgtgtgcaag ctagccggaa gtcctgtgaa tacactggac
     1621 tctttcttgg acaaagcaga ggaaaatgtt ctaaagttgt ctaaagccct tgagactgga
     1681 gaggaagaag tggctgagca aaaaggggca aaaagcttcc cttctgacaa acaaaacaca
     1741 ccttggccgc tgctccagga gaaaagcccc actgtctatg ttaaaccccc agattatgtg
     1801 gagattcaca aagtcaacaa agatggagtg ctatcattat tccccaagca gagagaaaac
     1861 aaccagacag agaagcctgg ggttcctgaa accagtaagg agtatgccaa ggtgtctggc
     1921 attacggata acaatatcct cgtattagtg ccagactcac gagcccagaa cacagcgttg
     1981 ctcgaggaat cagccaagaa ggctccacca tcgtttgaag ctgaccaatc tgagaaagat
     2041 ctggccagct tcactgcaac ctcaagcaac cgcagactcc aactgggtag gctggattac
     2101 ctggatccta cgtgcttcat gcactccttt cactgatagc tagacttatg gaacgattgg
     2161 ctaaactgtg atttctcttc aggtaacact acagagtcat gaagtaatgt ggtctgctag
     2221 caaatgttac aggatgtggg tataaaaaag aaaaaaagaa aaacactact tcactccttc
     2281 tcacgcttgt gttcatcgct tgcctctttt taacagctga tctccaaaac aaatcaactt
     2341 gtttcctgtg atcttgctct ttgcgcgcat atatatatat atatatatat atatatatat
     2401 atatatatat atatattgtt caatgtaatt aaaagcacat cgcttattat tcttgaggga
     2461 tggtgccaac aggtattagc ctctgcaata gatctgtcat ctgacaaaag gtatgatata
     2521 gtcaaaatga cttagcacaa gaagatgaca gatgggttga aaatgccatg aaaactgctc
     2581 ttaagaactg agggctaagc ctttacactc ctctttcatt ttcatgatga tggtccagat
     2641 agtgcacttt tttgaaagaa tacattccag gacaccagcc aaactgttta catcagtcgc
     2701 tttaccttaa ggacccattg cctgtacgca aatgggttca agcccctaat gctttcttaa
     2761 ggtgattcga gtatgttaag cctgggttat tctgctgaaa ctttatttta ttctaaggct
     2821 tctcgagtgt atagtttggg taaataaaat tttcttacaa agaaaggcca atgaattcca
     2881 catagggaac catttcacat gctctccttg cttcatttga gcagggggtg acttgttata
     2941 aacccgagta ttttcttagt agaaaaaaaa tttcccaaag actaacttta atctaaaagg
     3001 taatcattgc aggactctaa taggagtgtt gccttactgt acataaaatt ctactttaat
     3061 acaaacccgt aagtttcgca atgtattttt gaagactatt tttctatcgc ttaggtaaag
     3121 taaagactat tttctaactt cccagtattg ctgtttacgt attcgagtga gtagagtaat
     3181 ttctgctgcc aagttacaat gagtattcaa agttgttcag tgtatgcagt ccctgttaaa
     3241 ctgaagtgcc aggcaaccca ttgcccattg aggaatgcaa agtggatgaa aacaccaatt
     3301 gagtacaata gagtaaagtt tatctgatta ttttatcccc aggatacttc aaacagcaac
     3361 catcactaac tttgggtttt agagctttct atagacctat ttctcccatg agcttagggc
     3421 tctgcccacg tatgagtgaa tctcacaaac caccatgaac aaggatagtg gtggtggatg
     3481 agggtttcca agacagaaat ctgactttgt ttcatttact tttatcctga acacaaaagg
     3541 attttgagca aaatcaaacg tcagcatctc cttggaatac atccatttgt aagatcttgg
     3601 cagaggttgt gcttacgtca gggatgttaa gataaaagtt ttagggaagc aagcatctgc
     3661 ccagtgataa gaacagtttt aaaggtcagg ggatggtaga atcggcaagg caagtccaag
     3721 ggcaggcttc ctgagaaggt tcaaagcaaa gccttggatc tccaacagca tctatgactc
     3781 acgcttcctc cacttctcac ctattggcaa atcaagtctc tctcctttca ccgactggat
     3841 gtgaagactg aactcagatc ttgtgacgcc cagcgtcaca tggtggtaga agcaggactc
     3901 aaagattctc caatgactga aaggaaacct agagccaatg aacttccaga actccaaatg
     3961 caaacagcca aagcttatat tcctaataca caaagtatct tgtgaatggc agaagcattt
     4021 gagaaagatt gtccaggctc acgcaatacc ctgaaagcct ccatactgaa tgtctaagaa
     4081 ccaactgcat cacaggggca ctgcttggaa attgtgtttg cagcttctta agcttcttcg
     4141 aagacataca gaattggagt ctgaatttta ctgcctttac tcagttccca gataactcac
     4201 aggcatgatc gagctggaga agcatttttt ttctatgatc gttttcatga caaattattt
     4261 ttctctctgt tgcaaaggat gaagcaagcc tatttcactc aaaataaaca ctgtacgtaa
     4321 agagaaaaca aaaacaaaac tcttagtgat ttcagattca cataatgatg taacttatat
     4381 aaagtcacac aagacaatga gatgcaaaat atacataaac ttccaagagg gtcagtgaac
     4441 ttcactcacc ttgaaaatca ctgacaaaga agataaattc ctaagccagt gcagactaaa
     4501 ccgtctttcc caacatagtc tatcctaata aatcaatgca tttatttaca aatcaccact
     4561 ataaaattga tagtgcatcg cttgaaattt ctaaaaatcg gcttcagata tataattttg
     4621 caaatgtgga aaacatggct gtctgaagtt gttgcatcac aaaaataagt tagcattcac
     4681 ggaagaaaat caaatctaca tagttctact catttattga atttttgtgg tcaaatattt
     4741 tcaatctaaa gcttggatga aagaaggcat attaggggtc aagatacctg ggttctagtc
     4801 ctgtttgcct tggaaagacc aactgcctat tgtagctttc tctgtgttgg accaatcatt
     4861 tctacagcct tttgaaattc agtctctttg attctatggc tcagtgaata atcagaacca
     4921 atcccttgca tcttaatgac gttttcaggc aattagggaa acacagagtc actttcattc
     4981 atgtgctcat cctgcttcgc tctttaaagt ctcagcaccc atttgtcttc acatactgaa
     5041 catgtatttc acattatatg gacacggtgt aagtcagact ctaggatcat gtgcaaatat
     5101 gtgtgctaag gtaagatgta gcactaagaa agacacagga aatgagacat aagtctttag
     5161 aaaaagtacg ctttatgcat caagccatgc tcattcctac atggagccaa cagcctcaaa
     5221 gctctgttct cgtatttggt tgttgcctgt tttcccatca tcttgtttaa tgaataacca
     5281 ttgtccatgt agattaaaga accttttttt ctgcatcatt tttaaaaatg tatagttttc
     5341 taagcaacta tctaaaaatt tcaagttatg aagtacatgg aaactgaata tattcattga
     5401 ctttaggaca caaatggcaa aatgttctct gataaatttt aacaagtaca tagaaagaac
     5461 ttcactatga gcacaattta ccatcagcag tgtcactgac ttttaataga tgatacattc
     5521 tcctaagtgc ctgagaccaa tcctggtggt cagttatagg tcaatgattc actgtaaacc
     5581 agtttggtgg gaaacagtca agcccttgtt gcatgtgtaa aagtaaagct gggagactct
     5641 ttacttgata taatccaagg gaattggtga atcctcaatt aatgaacaac caaaggacct
     5701 gaactccagg ggaaagtttg tcctgatgaa aaattagctc tttttctttt ctctttagct
     5761 gcccatcatt tgtaaaatga ctcagcctgc ccttagcaac ctcaagttag catagacaag
     5821 aaagaaagag atttgtatat gtttacaaag tgcctttctt tatttttaaa aggtttcatt
     5881 ttggaagaaa aatgcgttga ttggaaggca aattttatct taaatggatt tcttttaaat
     5941 aaatggagaa atgaacaaaa aagggggatg acaaaatgtt ctaaagacta accaacaaaa
     6001 tgtcagggat ttttttttgc atatagttat gttgaatcat cacagaactg aataatatca
     6061 atcactttac ctgagtctga gcatgattgg tgatgaacct gaagcctgta attcaagact
     6121 ttccattctg aaaaaaaggt tgatgcattc ttgaatgatt cactgaatcg tgtgcctggc
     6181 cctgaagagg ccaatgtgta tacttcgacg ctctgcacac agatggaaaa gtagtaatga
     6241 ccttgaaatc tctcctgtga cttgctgtgg atgaaagttt catatatact tcatctaacc
     6301 aggtttcttt tctgactttt ttggctcaag cacaatactg actgatgcta gtaggagagc
     6361 ctctgagccc tcggtgtcca gctctgggtc atatcactgc tactaaatag gattctagac
     6421 cttgaatttt ttcaaattct gaccaccggt ttcccctctt ttaaataagt agggtgactc
     6481 tctcaaaaaa caaagtttct acaatttctt ctaggtctgt ctttaattct catgagttaa
     6541 gtaaaatcta agattgtggg tgaaaagccc aggggccaca gccaacatgc ccctaggcag
     6601 tgaatgcctg agactgtgtg aagaaatgct taacagaaaa ctaagatcca tggctccaaa
     6661 tcaggtagat cagaactctt gcaactctgc ctcctcgctg tttctacatt cgtagagcct
     6721 tttcagtccc tctttccaag acctgctatt ctccctaaag attaattctg tagaatagta
     6781 aagttgtgcc tacaggaaag aaattaccca taaacagtga tttgactctg cataagatga
     6841 atctgttaac tctccacaca gatacaaacc taaaatgagg tcataaataa tgcttcagtt
     6901 tgatatgaac atgttaaaga ttcaactcat tatctaataa atctgggctg tcttgatgag
     6961 taggtgttgg ctgtctttaa aagaaagttt aaaatataga actatttgct tcagagttta
     7021 tggttaaacc agaaaatcta cttataatta gagtcctttc ctatgaataa tagccattat
     7081 ctgtgaatcg catgggaatt ttccctgaga cttttatttt ccaaaaaggt aactttagat
     7141 ttgagctctg tgtgtatcaa tttccaatgg aggaaaaagg taaaaacaga atgctccaaa
     7201 atgtgggaca tatcagaacc ccaccaaatg gagtatccat tcactcaaat cttactggaa
     7261 atggtaaatt tacatgtaat tgtgagttaa ttgcagaggg gtaaacataa ctcataagac
     7321 cataggctaa cagcagttct tgtaacacca attcctttga tcttaagtta taaagcattg
     7381 agacacatac agtagaaagg caaccatcta aacagtctag tcaatgagta aagggactca
     7441 cagataatct taccatggtg attaatattt acctactgtt gtttaaaaag agaaggaaaa
     7501 attctaaaag tttttgtgac taaaacagta ctatcaaaca taaactttaa tagttatggt
     7561 caagttgtgc ccccccgaat acactcaaaa tacagacttg atttttctgt gcacattttg
     7621 caaattgggg cggcaatctt tttatcacat tctctaaaat gaaaaacaat aaaaagaaat
     7681 tttatgtgaa aatacctctg aaagtcattt gttttactaa attcctgaga aacagatttg
     7741 gaatttttaa aactacctcc cttctacatc ctaatgacct tccttcaaag ctgcttatag
     7801 ttagaaatga aagataccac atgttatgtt tggactggtg tttgatggaa tatttgatat
     7861 acttttcctg tgacactcct aactctatta ttttacccta tttttgcttt ttgtgatcca
     7921 aaacctatat atgccatatt gaaatacata atcctcttgt tgtaaaattt attatgtaat
     7981 acaagtaaaa tcattattta atgacttatg ctctaaccat atctaatttc aatataattg
     8041 tgtctatgta aagtgaaatt aaatatatgt aatcatgtat gtaatcatat atttctgttg
     8101 aaactgtgaa tgtactgatt ttccctttaa tctttgtcta caagtgatag tatatgtcat
     8161 tgtataactg acttggggta ctaatgtgtt taaagtacaa tccaccaatt attgaaatgt
     8221 caaccttttg gcttcgcttc ttgtgatccc agagcgttct ttgcaccttg agacttgctt
     8281 ttgtgctttt gtgctctgtc attaatttta aacaatgtaa gaatctcttg tataaaccaa
     8341 agtaatcaga tgcagcccac tgagtgatca tgccttctgt aaagccatac tgaagcacag
     8401 actccgctgt cgcataaggt cccctctttc cagagctgcc actacctcgc tcctgctctt
     8461 tccctacaaa ttgccaagct aagtttaccc ttaagtggaa aattagaatt catcgctatt
     8521 gttaccattt ttaacctgat aataaacctt ctaattcatt actttgcaga tatatgctag
     8581 gttttatgaa taactatttt tacatcttgg tattttgtag actttggctg atgagtaaag
     8641 tacagaaaga ctatacagta agtcatcaga tttaaaagaa aaaagtcata gagtgcaggt
     8701 atttttttcc tatcagtgag tcaactcaag atggttggcc aaagcaatta caacctgggt
     8761 ccctatattt gaagcaccca attcagtgcc tggctctaag atgtttatcc cctttgcctc
     8821 tcttggttct attttttgtt gctgttgttt gaaatgcaaa tgaacagaat tacatggatg
     8881 tagaggaagt gattttctaa ttttttgctg ccagatctgt aattataaat tcgcaattta
     8941 atttccccaa actcccaaga aataaatatt ctctttattt gattttaatc atcaaataca
     9001 ttatggtatt ggaagagtcg ggtatttatc agaaacaaca ttgtttcgaa cttaaaagac
     9061 tcatttttat gtgtcactac tgtgatatca actgttttct tttagcatta aagggttata
     9121 tggttatatg gttaaagggt cttatgattt atcctcctac attttttact ctgcaaatct
     9181 tgagttattg cacattgtac ttcctagttt tcaagaatct attcatttgt ctccatcaac
     9241 tttgttggga caacatggac agttaaaact ttgtcaatta tatgaagatt atgctaattt
     9301 ctctcacatt tttactgcat gctaaaaata atgcttgcca aatggaatct tagacatccc
     9361 agaataatat ggtcactata tttctatttc tgtcattatt gaaaataccc agctcagtgc
     9421 ctggctcaat aaatgtttgt ttcccttg
//
LOCUS       NM_001437855            3702 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            gamma (Camk2g), transcript variant 5, mRNA.
ACCESSION   NM_001437855 XM_008770493
VERSION     NM_001437855.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Yang,X., Sha,X., Cao,Y., Wang,W. and Shi,J.
  TITLE     Cx43 overexpression reduce the incidence of obstructive sleep apnea
            associated atrial fibrillation via the CaMKgamma/HIF-1 axis
  JOURNAL   Biochem Biophys Res Commun 659, 62-71 (2023)
   PUBMED   37037067
  REMARK    GeneRIF: Cx43 overexpression reduce the incidence of obstructive
            sleep apnea associated atrial fibrillation via the CaMKgamma/HIF-1
            axis.
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   He,X., Wang,Y., Zhou,G., Yang,J., Li,J., Li,T., Hu,H. and Ma,H.
  TITLE     A Critical Role for gammaCaMKII in Decoding NMDA Signaling to
            Regulate AMPA Receptors in Putative Inhibitory Interneurons
  JOURNAL   Neurosci Bull 38 (8), 916-926 (2022)
   PUBMED   35290589
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Huang,R. and Bi,G.
  TITLE     MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma facilitates
            vestibular compensation in acute vertigo by promoting protein
            kinase C expression
  JOURNAL   Ann N Y Acad Sci 1475 (1), 78-88 (2020)
   PUBMED   32645222
  REMARK    GeneRIF: MicroRNA-219a-5p-mediated inhibition of CaMKIIgamma
            facilitates vestibular compensation in acute vertigo by promoting
            protein kinase C expression.
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Zhao,L., Xiong,L., Hao,Y.H., Li,W.C., Dong,J., Zhang,J., Yao,B.W.,
            Xu,X.P., Wang,L.F., Zhou,H.M. and Peng,R.Y.
  TITLE     Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity
            via Activating NMDAR1, CaMKIIgamma, and p-CREB after Microwave
            Radiation
  JOURNAL   Biomed Environ Sci 33 (5), 359-364 (2020)
   PUBMED   32553080
  REMARK    GeneRIF: Inhibition of MicroRNA 219 Expression Protects Synaptic
            Plasticity via Activating NMDAR1, CaMKIIgamma, and p-CREB after
            Microwave Radiation.
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Liu,Y., Sun,L.Y., Singer,D.V., Ginnan,R., Zhao,W.,
            Jourd'heuil,F.L., Jourd'heuil,D., Long,X. and Singer,H.A.
  TITLE     Thymine DNA glycosylase is a key regulator of CaMKIIgamma
            expression and vascular smooth muscle phenotype
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (5), H969-H980 (2019)
   PUBMED   31518169
  REMARK    GeneRIF: Thymine DNA glycosylase plays a key role in regulating
            CaMKIIgamma expression in vascular smooth muscle cells through
            promoter cytosine methylation/demethylation.
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Singer,H.A., Benscoter,H.A. and Schworer,C.M.
  TITLE     Novel Ca2+/calmodulin-dependent protein kinase II gamma-subunit
            variants expressed in vascular smooth muscle, brain, and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (14), 9393-9400 (1997)
   PUBMED   9083077
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Zhou,Z.L. and Ikebe,M.
  TITLE     New isoforms of Ca2+/calmodulin-dependent protein kinase II in
            smooth muscle
  JOURNAL   Biochem J 299 (Pt 2) (Pt 2), 489-495 (1994)
   PUBMED   8172610
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Tobimatsu,T., Kameshita,I. and Fujisawa,H.
  TITLE     Molecular cloning of the cDNA encoding the third polypeptide
            (gamma) of brain calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 263 (31), 16082-16086 (1988)
   PUBMED   2846534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 10, 2025 this sequence version replaced XM_008770493.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2551152.1,
                                           SRR26643298.56234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000015.1  3553322-3553455
            135-229             JAXUCZ010000015.1  3554780-3554874
            230-289             JAXUCZ010000015.1  3568253-3568312
            290-344             JAXUCZ010000015.1  3576050-3576104
            345-410             JAXUCZ010000015.1  3576930-3576995
            411-483             JAXUCZ010000015.1  3580329-3580401
            484-586             JAXUCZ010000015.1  3580559-3580661
            587-670             JAXUCZ010000015.1  3581097-3581180
            671-765             JAXUCZ010000015.1  3581604-3581698
            766-888             JAXUCZ010000015.1  3582328-3582450
            889-972             JAXUCZ010000015.1  3586196-3586279
            973-1015            JAXUCZ010000015.1  3586516-3586558
            1016-1078           JAXUCZ010000015.1  3588877-3588939
            1079-1122           JAXUCZ010000015.1  3590901-3590944
            1123-1155           JAXUCZ010000015.1  3598315-3598347
            1156-1224           JAXUCZ010000015.1  3600390-3600458
            1225-1269           JAXUCZ010000015.1  3601575-3601619
            1270-1318           JAXUCZ010000015.1  3604223-3604271
            1319-1394           JAXUCZ010000015.1  3607566-3607641
            1395-1489           JAXUCZ010000015.1  3607997-3608091
            1490-1734           JAXUCZ010000015.1  3609598-3609842
            1735-3702           JAXUCZ010000015.1  3610343-3612310
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3702
                     /gene="Camk2g"
                     /note="calcium/calmodulin-dependent protein kinase II
                     gamma"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
     exon            1..134
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1722
                     /gene="Camk2g"
                     /EC_number="2.7.11.17"
                     /note="isoform 5 is encoded by transcript variant 5;
                     calcium/calmodulin-dependent protein kinase type II gamma
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit gamma; Ca+2/calmodulin-dependent protein kinase II
                     gamma; caMK-II subunit gamma; caM-kinase II gamma chain;
                     caM kinase II subunit gamma; calcium/calmodulin-dependent
                     protein kinase (CaM kinase) II gamma;
                     calcium/calmodulin-dependent protein kinase type II
                     subunit gamma-like"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit gamma isoform 5"
                     /protein_id="NP_001424784.1"
                     /db_xref="GeneID:171140"
                     /db_xref="RGD:621802"
                     /translation="MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGL
                     AIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED
                     QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS
                     TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA
                     GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVV
                     HNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLT
                     SFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQ
                     YIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    103..978
                     /gene="Camk2g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..141,151..153,190..192,196..198,289..291,
                     337..348,358..360,364..366,472..477,481..483,487..492,
                     496..498,535..540,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(127..138,151..153,190..192,196..198,289..291,
                     337..348,358..360,487..492,496..498,535..540)
                     /gene="Camk2g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(139..141,358..360,364..366,472..477,481..483,
                     487..489,547..549,592..606,610..612)
                     /gene="Camk2g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(535..567,574..606)
                     /gene="Camk2g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(949..951,955..978)
                     /gene="Camk2g"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1321..1704
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1321..1704
                     /gene="Camk2g"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     exon            135..229
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            230..289
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            290..344
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            411..483
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            889..972
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1015
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1078
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1122
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1155
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1224
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1269
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1318
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1394
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1489
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1734
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..3702
                     /gene="Camk2g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcct cttgctccct cggccgggcg gcggtgactg tgcaccgccg cgtccgcccg
       61 cccgccagta tggccaccac cgccacctgc acccgcttca ccgacgacta ccagcttttc
      121 gaggagctcg gcaagggtgc cttctcggtg gtccggaggt gcgtgaagaa aacgtcgacg
      181 caggagtatg cagcaaaaat catcaatacc aagaagttgt ctgcccgaga tcatcagaaa
      241 ctagaacgag aggcccggat atgccgactt ctgaaacatc caaacatcgt gcgtctccat
      301 gacagtattt ctgaagaagg gtttcactac ctcgtgtttg accttgttac gggaggggag
      361 ttgtttgaag acatcgtggc cagagaatac tacagcgaag ctgatgccag ccactgtata
      421 catcagatcc tggagagcgt caaccacatc caccagcatg acatcgtcca ccgggacctg
      481 aagcccgaga acttgctgct ggcgagtaaa tgcaagggtg ctgcggtcaa gctagctgat
      541 tttggcctgg ccatcgaagt gcagggagag cagcaggctt ggtttggttt tgctggcacc
      601 ccaggttact tgtcccctga ggtcttgagg aaagatccct atggaaaacc tgtggatatc
      661 tgggcctgcg gggtcatcct gtatatcctc ctggtgggct accctccctt ctgggatgag
      721 gatcagcaca agctctatca gcagatcaaa gctggagcct acgatttccc atcaccagaa
      781 tgggacacag tcactcctga agctaagaac ttgatcaacc agatgttgac cataaaccct
      841 gcaaagcgta tcacagctga ccaggctctc aagcacccat gggtctgtca acggtcaaca
      901 gtggcatcca tgatgcatcg ccaagagaca gtggagtgct tacgcaagtt caacgcccgg
      961 agaaaactga agggtgccat cctcacaacc atgcttgtct ccaggaactt ttcagttggc
     1021 aggcagagct ccgcccccgc ctcgcctgcc gcgagcgccg ccggcctggc cgggcaagct
     1081 gccaagagcc tattgaacaa gaagtcagat ggcggcgtca agaaaaggaa gtcgagttcc
     1141 agcgtgcacc taatgccaca gagcaacaac aaaaacagtc tcgtaagccc agcccaagag
     1201 cccgcgccct tgcagacggc catggagcca caaaccaccg tggtacataa tgctacagat
     1261 gggatcaagg gctccacaga gagctgcaac accaccacag aagacgaaga tctcaaagtg
     1321 cgaaaacagg agatcattaa gatcacagaa cagctgatag aagccatcaa caatggggac
     1381 tttgaggcct acacgaagat ttgtgaccca ggcctcactt cctttgagcc agaagccctt
     1441 ggtaacctcg tggaggggat ggatttccat aagttttact ttgagaatct cctgtccaag
     1501 aacagcaagc ctatccacac caccatccta aacccacatg tccatgtcat cggcgaggac
     1561 gcagcttgca tcgcctacat ccggctcacc cagtacatcg atgggcaggg tcggcctcgc
     1621 accagtcagt cagaggagac ccgggtgtgg caccgccggg atggcaagtg gctcaatgtc
     1681 cactatcact gctcaggagc ccctgctgca ccgctgcagt gagctcaggc acaggggcat
     1741 taggagattc cagctggagg ctgaaccttc gaagtcagtg actctggagg gcctgagtga
     1801 cagccgcggt cctgtccatt tgaggtttaa aacaattaca ttacaaagcg gcagcagcca
     1861 atgcacgccc ctgcatgcag ccctcccgcc cgcccttcgt gtctgtctct gctgtactga
     1921 ggtgtttttt acatttaaga aaaaaaaaag aaaataagat tgttttaaaa aaaaatggaa
     1981 ttcataccat gatgcgtttt aaaacaactg atagcctttg ggcttgaaga aggcaggagt
     2041 ttgtatgatg ctcatccagg cgtgaacaga gggctcaccc actggctttg aagaggtgag
     2101 cttggcctca ggcccccatg gactcggggg ggaccaggca aggactcttg acagagcttt
     2161 ggtcatggac agagccatgc tgtggttgca gccccggtgg tgacctgatc actccaggtc
     2221 taggagtgga cttcttcaga atatacattg acacctagta tgagaaagaa gaaaactcca
     2281 tggctaacag acctacttgg gagagaacgc agcgctccca gcccgctgtg gaggcaactg
     2341 tgaagcgtgg cctcgggact gaaggcctgg actttgccgt accgttccag ttagtgtaga
     2401 caggaagaga attggtgctg cagaagtgtg tccgacacag agccggtgtg aaacctcgcg
     2461 ttagtctgac acgcacttac tcatccattt ctataggatg cacaatgcac gtgggcctga
     2521 gactgaggcc tgatttctgc aggcgagaag ggggtgggat tgctactttg tttcctgttg
     2581 gttttcctaa tgtatcaagg agagatccag acatcgttgg ccagggctcc tgttgccact
     2641 ttctgcagtt gtgtttgtgt gcggatctgg accactttgt cttatatttt cgtggcggtg
     2701 gtccccatgc cgaccctctg ccaagtgccc ctgcgggatg ggaggagtga gataagagtt
     2761 ggtggttgtt tctatgcatt ctggctgccc tctgggctgc ctcccttctt cccgtgctgc
     2821 acgtccgtct ctttccctga gtttgagatt gaaccgactg cttgggtgag aagtgtcctc
     2881 tttaatgagg ctctctaccg accaactgaa gtatagactt ttctgctgga caatctgcat
     2941 gggcatcacc ccctcacctg catgtaccca aaaaggggtc cagagccaag gctcctgtag
     3001 tcattgtccc tctctgtgct caaggagttc ctttccagga ggaaaagatc tgtaccttag
     3061 gcagataaca gagaagacaa tggaggagca attggtcata gtcttggttc cctcccaccc
     3121 aacagctgca cactatctgc attttggggg ggaaggtggg ttgacttcag ctctttggat
     3181 gaccttcagg gaggcacagg agctgggaaa agatacagaa ctacagactt tggaaccagc
     3241 tgagaagaga acaaactcat gggtgctggt gcttgaattt agccaggctc ctcaagcacc
     3301 ttgtgcatgc ctcagaccct ggaccctagc cccttcctgc cctgcagcct gcagtgccag
     3361 ccaacagatc ccttcaccac agggtttggt tttgctggct tgaagacaac aaatggtctt
     3421 agagctcatt gagacccata gcttcatatg gctgctccag ccccacttag cgttcttact
     3481 ccacttctgg ggctaatgtc agcatctata gacaattaat agactattta aaaaaaaaaa
     3541 ccacctttta aacaggaaat gaaaggcatt tgatgcagaa cttttgcatg acgacataga
     3601 aataatttaa aaatagtgtt tgttctgaat gttggtagtc ccttcatagc tttgttacaa
     3661 tgaaaccttg aagatattta ataaaataac ctttaaacag tc
//
LOCUS       NM_001437799            7772 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus regulator of G-protein signaling 17 (Rgs17),
            transcript variant 1, mRNA.
ACCESSION   NM_001437799 XM_006227854
VERSION     NM_001437799.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7772)
  AUTHORS   Dhukhwa,A., Al Aameri,R.F.H., Sheth,S., Mukherjea,D., Rybak,L. and
            Ramkumar,V.
  TITLE     Regulator of G protein signaling 17 represents a novel target for
            treating cisplatin induced hearing loss
  JOURNAL   Sci Rep 11 (1), 8116 (2021)
   PUBMED   33854102
  REMARK    GeneRIF: Regulator of G protein signaling 17 represents a novel
            target for treating cisplatin induced hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7772)
  AUTHORS   Sun,H., Calipari,E.S., Beveridge,T.J., Jones,S.R. and Chen,R.
  TITLE     The brain gene expression profile of dopamine D2/D3 receptors and
            associated signaling proteins following amphetamine
            self-administration
  JOURNAL   Neuroscience 307, 253-261 (2015)
   PUBMED   26321241
REFERENCE   3  (bases 1 to 7772)
  AUTHORS   Sokolov,E., Iannitti,D.A., Schrum,L.W. and McKillop,I.H.
  TITLE     Altered expression and function of regulator of G-protein
            signaling-17 (RGS17) in hepatocellular carcinoma
  JOURNAL   Cell Signal 23 (10), 1603-1610 (2011)
   PUBMED   21620966
  REMARK    GeneRIF: RGS17 is differentially expressed in hepatocellular
            carcinoma cells and plays a central role in regulating transformed
            hepatocyte tumorgenicity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006227854.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.334788.1,
                                           SRR26360176.2124595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000001.1  44729788-44729916   c
            130-273             JAXUCZ010000001.1  44672850-44672993   c
            274-363             JAXUCZ010000001.1  44652184-44652273   c
            364-598             JAXUCZ010000001.1  44649951-44650185   c
            599-7772            JAXUCZ010000001.1  44627583-44634756   c
FEATURES             Location/Qualifiers
     source          1..7772
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..7772
                     /gene="Rgs17"
                     /note="regulator of G-protein signaling 17"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
     exon            1..129
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    53..55
                     /gene="Rgs17"
                     /note="upstream in-frame stop codon"
     exon            130..273
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..787
                     /gene="Rgs17"
                     /codon_start=1
                     /product="regulator of G-protein signaling 17"
                     /protein_id="NP_001424728.1"
                     /db_xref="GeneID:308118"
                     /db_xref="RGD:1305515"
                     /translation="MRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVR
                     NEERGDSSGRPPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKAPAGRNLFREFL
                     RTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN
                     RNLLEPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTASSTSES"
     misc_feature    275..745
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     misc_feature    275..745
                     /gene="Rgs17"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; Region: RGS; cl02565"
                     /db_xref="CDD:470619"
     exon            274..363
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            364..598
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
     exon            599..7772
                     /gene="Rgs17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccgtcg ccgggtgctg aagttgggcg gatggcaagg agcccgctcc gctagaggac
       61 ggaacagccc agccttgagc acactcggac tcggacccgg ggacggtcgc ccacatccca
      121 ggccacctgc cagtcggatt ctgaagcagc tgacatgaga aaacggcagc agtcacaaaa
      181 tgaaggcacg caggctgtgt ctcaagcgcc cggaaaccaa aggcccaaca acacctgttg
      241 cttctgctgg tgctgctgct gcagctgctc ctgcctcact gtcaggaatg aagaaagagg
      301 agactcttcg gggagacccc cacacaccac caaaatggag agcatccagg tcctagagga
      361 atgccaaaac cccactgcag atgaagtctt gtcctggtct cagaattttg acaagatgat
      421 gaaggctcct gcaggaagaa accttttccg agagttcctc cgaacagaat acagcgagga
      481 gaacctactc ttctggctgg cctgtgaaga cttaaagaag gagcagaaca agaaagctgt
      541 tgaagaaaag gccaggatga tatacgagga ttacatttct atactgtcac cgaaagaggt
      601 cagcctcgat tctcgagtta gagaggtgat caacaggaat ctgctggagc ccagccctca
      661 catgtacgaa gatgcccagc ttcagatcta caccctaatg cacagagatt ctttcccaag
      721 attcttgaac tcgcagatct acaaagcctt tgtcgaaagt actgccagct ccacttctga
      781 atcttaattt tcatttgaaa ggccaaaaaa aaaatcattt cagagggctg ggatgggaaa
      841 taaaagtaat taaataacat cagaaatcga gttcctgaaa aaaacgacag gttggctgct
      901 gggaaaagac aactgggaaa gtcgtttgtc tctattttta tcaaggttat ccatgattct
      961 gttagggggt aaaaagcctg tgtaagaaaa tgagttgcca aattgagttt gtttgattca
     1021 acacttgctc tccttgcaag cgaactatgt tcctagtcct ctgaacaatc ccctagtgca
     1081 tctctagagg ccgcatgtgc aaagtaaaac cgcttcgtct gccctttact tgtgccatta
     1141 agtcagtagc ataccttgta tctgtattta aggacttctg tgcaatatgg tctcttagaa
     1201 acaattgcca acaaattggc cgtggtttgc attttttaag cataatctga tacacacaaa
     1261 ggctatttta aacatgtaac agtgatattt aaccacgcta catactatgt ttagtacatg
     1321 gactctgaag ccaatttttc tgtacatgtt aaaaaaaaaa gtgaccattg aaggacctta
     1381 ttgtgtgaga cctctggttg ttcactgccc acattctgac atttttgtta cagaagagtt
     1441 tgctatatat atattttaag agaaagaaaa gagagaaaaa gaaagaaaac aaaaatagtt
     1501 aacaatgata agaaaaattt taaaaagcac aaaacaatct gcagatatcc tgtctcgttg
     1561 aaaattccaa gaaggatact atttttaggt ctaaaagaaa gaaaagagtc tatgtatata
     1621 tcagatgtcc aatagtgtaa ttaatttatc aaagaaaggc tcttcagttc taaaagcatt
     1681 gcataaacct atgactgtca gcaggtaaac aataataagt tcagtaaccc agtttgggaa
     1741 tagaacggga agggtaataa agaaatgcct acatgtagca ctgtaaaagt cacctttgag
     1801 gagtcgcctc tgtgtggcgc gctcaccttg aacgtgtaat tcagtgaaaa gcttgagttt
     1861 ttcctaacca acattttaca agggattata gagaagaaag ccttcgatgt cagaccttaa
     1921 ctgttttcac cgtagtctct caagaaagac ttatttttaa cattgttaaa atcaaactac
     1981 caaccctcgt ccgtaactag aaggcagtgc agtgctcaat ccttttagct gccaatatta
     2041 ttttttataa ttacattaac tctttacacg gatactcaca tgaccatggt atgcatttct
     2101 gaccttcaga acagtatcgt cttgtgcaca aaaccaaaat tacaatcaat gtcatattta
     2161 tatcaaggtc ctacctttca atatcaaaat cccctggaga ctattttttt aatcttaaac
     2221 tcaatgaata tatgttgagt aacctttaaa aaatgaaaga tttaaaaaga tttataacca
     2281 ctgagaatac tggccttata ttaaggatga tattaaaatt aaaggttttg tttgtcattt
     2341 ttaactacct ctcagttttt aatttattaa acatattttt ttaagatgca agtttggagt
     2401 tttctttttc actttatttt acttgaaagg ttggcatcat gtttcttttt ccataaattt
     2461 aaaacatttc aagaattgtt ttttaagtga atatgatttt ctaatttata tagaattcag
     2521 gagctatgat taaaagggct attacatatt ccctatgcaa atattttaac tgttgcagtg
     2581 tttgacaaaa tgggattaaa aaaaaacagt ttgcagagtg gaaaacaaaa tgttgtgttt
     2641 acactggcac cgctgaccat cctactacgc tcagtacttt taaatacatt atttatggaa
     2701 acatagttaa aatgcaagat agaaggtatt tataatagtc atcttttagc aaatgcctgt
     2761 ggactctttt ctgaaagtgt tagtgtgttt aagacgcgct ttgctcatgt ctcctagata
     2821 tttactcttt gaatagtttc agtaatctgt cgagaaaaaa gatagctatg aagatgttta
     2881 caaaaaaaat cctatttttt cctaaagagt caagaaaacg taaaagcgtc gttgcttctg
     2941 ttgtgaagtc ccatcgttct aaatgatttc attgttttct tgataagtgt ttattatgct
     3001 aatatgatgt gtatgcctat ctagtgtacc atcatctcat ttctgtgttt gaggcacaat
     3061 gaattggtgc acatgaccag gagatttgta atatactacg aagccctgca tgcacaattg
     3121 tttttgatgt agactttatt atattccctg tactgcggat gctcgtgact tactgtcaca
     3181 ggtgatcttt acaatatctc tggactacta ggcgagttgt ctgcttgatc atgcatttac
     3241 tcttttacca aatgtaagaa gaggtaaggg ccgttaaagg gtcctcatct ctaacctagg
     3301 catttgcagt gtttgcttca aagttgctgt gtctttggag cctggttacg aagcttcact
     3361 gacgaggtcc taaggcggat ttgcacagcc gctgtccttg gcgatgctgt gtgggcagct
     3421 ctgtgttgaa ttcctatttc agggggatgg cttctcattt cacttctgaa tgtttcaagt
     3481 tttagagagt gtgcctgtgg acttgtgact atgccggttt tcaaagtatg gtgtgatttc
     3541 ttctgtttaa gtcacagagc tacaataaac aaacaaaagc cctcaactgg tgtctctgcc
     3601 accatttcaa gagcacaaca tttgctttat tcaaaattga ttgaattctc cttggggaga
     3661 ccctagcact ttaagtgaag caccttgcat tgatgattgc caagataact ttgtatattg
     3721 ttagaatccg ctaatgcaca cacaagaggt taatgcactt tctataggtc tgtctattgt
     3781 ggaaagaaaa ggagattgta taggtgacgt atatagaggt ggctcaaaga cagatgtctc
     3841 cataggtgga tcttacacat agacatgcta atgctggagg gagggtggct cctctttctg
     3901 gcttattacg atgtcatcca aagtaagcac acatgctctg acagcatgac aaggcacaga
     3961 tgaatgtaag caaaaacgga ccttgataca gaagttataa atgaaaaagt caaaattata
     4021 atatggcctt taaaacattc ttacaatgtt tataaatgac cagctgttct aacagtgtgt
     4081 cactgtgcct agaacattta ttagcgagca cccttcagtg tctcctagta taaagaatgt
     4141 gctctattta tttgatagtt gagtgtcaaa ggactgtaga aatagataga ctaatctgtt
     4201 gaaaacaata tacatctccc ccattgtatt aacttaatac ttgaatctta atttaagttt
     4261 attctttttt ttttctagaa ttttttaaat agtctcagaa aaagtcacat tataattgtg
     4321 gaaactacac ttgcaacaaa taaaaatttt caggtgcttt ggtgaaggtt tttaaatgga
     4381 aggaatggaa ataaagtata gaaaagtgaa ctttttgaaa aaccatccat ttgtttttaa
     4441 acggaagata tacctagacc ccccacataa catgaatttt tgaattcctt tggctttata
     4501 tattcgtata ttatctcgaa ataggaaata cagccaaaaa aattgggtta tctgtctatt
     4561 tagattggca gtgagtgacc aatctccaaa gtatctattt ttgaaactgt gagcgtactc
     4621 ctttctgttt tcaaatttcc gatcaacaga aaatgctgtc ctttgatagg agcacgccac
     4681 gcgtaataac gttagtaatt cttcacttgc cacgactgca ggtaaaacca ctaaaaccta
     4741 ccgagccttc cttcagaaca tatctgcaag attatgatat ggctaagata tcaccacaac
     4801 acacatagtg aatgaaagag cactggcttt gatttctgcg tatgttaaga aatattactc
     4861 ctacagaaat agtcctaagc ggctataagg gacatgcttt ctttcccact ggttgaagag
     4921 aacacaccat accatcattc tattgaaaac atggagagat ggagtgttcc ttagttgggc
     4981 aaatggggtt gagaactcat ttgattctca tgacaaatgc tccaagttgg gaaaaagcag
     5041 ttatctaaag cacccatgat gacaaccaca cgagatatca cagtgtcatg catacaatct
     5101 gaaattcagt tccctcctct tgtcttacat caagtatttt ctgttgcaaa ctttcccatt
     5161 gattcatagc ttcatcacgg catttcagct ttttaaacag ttagaagtgt gtgcgtccta
     5221 aactgatgat taagcaaact gtctaaggtc tgggcacatt tccgtttgaa aggacagagc
     5281 tggtatttac atccagagat ggtaggaaaa gtcatgtaac ctttctgaat ctgtttcttc
     5341 atctgaaaat gaatattgat tatggggtgt ccgttggaac aataatgttg catataataa
     5401 ttgatcaaga gttcttcagc ccagtcatag tcacattttt agtaagtgac attttagcgt
     5461 actctcccct tgtttccttg gaatggtttg gttagcacac aaagagggtt tcatcatgcc
     5521 attttcatac tggtgtcttg ttatatcctg ttctcttttg taccccactg cctttccctg
     5581 ggccttctac tttctctgct tattttttta aacatacttg aaaaatttaa atatgcacag
     5641 gcacacacac tcaccacaca cacacagcaa cacacacaga cacagataca cacagacaca
     5701 tgcacaagca cacatacaca cagacacatg caacaccccc acacacacat gcacagacac
     5761 atacacacag atacacactt aaagatggag acctaggaca taaaatcgcc atccccacga
     5821 atcagaaaca tagaatcaag ttagttacaa atacaccaag tatgccactg gatgacagag
     5881 ccaaaagcaa gttcataaag catgactgaa aatcaatccc ttcaatatta gtgtgactgt
     5941 caagtttatc atgatactct gaatagaaag attattaata caagtggcta agtgttcatt
     6001 aatagtttca ccaaatttta gaatattttc agcttaatgg aaaaattaca aaggcagtac
     6061 aaaatgccct ggtgtgttct ctgtgtctgg aaaacaatta ttcccaatta ataactaatg
     6121 ctgccccatc aaggttgtac acatcatcct gacacttctc ttgtcttctc tctacccttc
     6181 ccatcctaaa accatgtgac ctcttattgt cacccttcgt tgtatttctt tcagctgtga
     6241 ctctctataa atgttcttgt gtttttcaaa accttgacag ttttgagtgg aaatgacatc
     6301 tattgtgtag agcatcactc tgcagggtgg gatttctcat ttttagacta gcgcttttgg
     6361 tttctggaag gaataatgtt attctgttct ttctatcata aagatttgtt ttttatttta
     6421 tgtgtgtgag tgttttgtct gcaagtataa atgtgaccac atgtgtgcaa cacctaaggc
     6481 cagaagagtc cgctgaaatt ggagctacag atggtcttaa ggcttcatat gggttctggg
     6541 aactaaatca ggggcttcag taagagcagc aagtgcttta attgttgagc cacctgccca
     6601 gccctggata gccaacctcg ttacatgata tctcaaaggc acatgccacc cgggtaagta
     6661 ctcttgcttt ggggtccttg ctgttgctgt tgcagtcacc ctgtcacctg tttaaagcat
     6721 tgccttttgg atacagcctc tctgctgcca agtgatatgc atgcaaagaa ggtacctgag
     6781 agtgaaatag accctgcatt acactgtgca agaaaaacaa ccaacaacca accaaccaag
     6841 caaacaaaaa caattctggc caaagtctta gcatgaatac taggctccat taaaggatta
     6901 ctaacaaata ctacaaagaa aatggaatgg attaggaaat gaaatgaccc aaatcagtgt
     6961 tagcttggat atctacttat gaaaagtgca actgttcccg ctttcctgaa ataccccggg
     7021 tagttattaa atcctgctca catgctggat ttgaagattt tagtctcatt aattgtagca
     7081 agaggttgct aattactcat gcttaatgcc ttcctgtata tcatccactg agctgtgtgt
     7141 acaatgctga agtgtagagg acttgatgtt gctcctcaag ctttaacctg tttgtcacag
     7201 tgtttcttgt gtgtgatttt aaagagtttg caaaatgtta aaacgtattt taccgaattc
     7261 gactctgtga aattcatttt gaacgtgtct gatttcttac ttccatgctc accctattta
     7321 gtgatctatt tccacatttt gcattcactg atgtatttat tagtgaacca caaaaaggtt
     7381 ctgagtacat gaatacaaga gcagccctgc ttgtccattt tataatacca aaatatctgt
     7441 gggtactcat agttgactag aaaatccaga ttctttttct tgcagctcaa aattttctgg
     7501 gtttttattc cattgaacca atttcatcat ttacctatgt acaataatag acttcttgaa
     7561 agtgttacag tttttgccat gtaatagatt tgagcatgac aatactgtaa gaaaacccag
     7621 acgtctgagt tttcaaagga aatcaaatag gtgttttcat ttaactatat tgtggcaatt
     7681 tatgggtatt attgtaaaat gcatatgcat tacactgatt ttcttaatgt gttttgaatt
     7741 aataaagaat tctcccatgt atccttagac aa
//
LOCUS       NM_001437823            2568 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus sphingosine kinase 2 (Sphk2), transcript variant
            2, mRNA.
ACCESSION   NM_001437823 XM_006229085
VERSION     NM_001437823.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (bases 1 to 2568)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (bases 1 to 2568)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (bases 1 to 2568)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006229085.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.1933.1,
                                           SRR26643299.2480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000001.1  105324846-105325054 c
            210-681             JAXUCZ010000001.1  105320341-105320812 c
            682-831             JAXUCZ010000001.1  105319532-105319681 c
            832-926             JAXUCZ010000001.1  105319331-105319425 c
            927-1042            JAXUCZ010000001.1  105319133-105319248 c
            1043-2568           JAXUCZ010000001.1  105317326-105318851 c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2568
                     /gene="Sphk2"
                     /note="sphingosine kinase 2"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
     exon            1..209
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..681
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    261..263
                     /gene="Sphk2"
                     /note="upstream in-frame stop codon"
     CDS             276..2126
                     /gene="Sphk2"
                     /EC_number="2.7.1.91"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sphingosine kinase 2 isoform 1"
                     /protein_id="NP_001424752.1"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
                     /translation="MAPPPLLPVAASTPILHGEFGSYPAHGPRFALTLTTQALHIQRL
                     RPKPEARPRDGLVPLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRA
                     DGAATYVENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGL
                     AWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEV
                     LNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRG
                     GSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATL
                     HTYRGRLSYLPATTEPALPIPGHGLPRAKSELALAPAPAPAATHSPLHRSVSDLPLPL
                     PQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNAFKTAQLSP
                     IAEGPSEMPASGLLPPIHNAPEASTWGPADHLLPPLGSPLPQDWVTIEGEFVLMLAIL
                     PSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYA
                     AARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHPSLATLLTGPAGQKPRA"
     misc_feature    <729..2096
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     misc_feature    <729..2096
                     /gene="Sphk2"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
     exon            682..831
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..926
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1042
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2568
                     /gene="Sphk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaaac cagccagagg aaagggacgg gtcgctggga gcctctctag cctttcccag
       61 tccttgttct ctatattctt cagggatata ggaacctgag aacgagagac atgcttggag
      121 tcagctggag gaatcgcgtg gtgactctct ggccgcacac cgaccgcttc tcggtggtcg
      181 cggaggaccc ggtgggctgt gagttggaga ggctggacca ggagctgacc acaagccaag
      241 agtctagaag tgcttgggac tgaaccaagg tcgtcatggc cccaccacca ctactgccag
      301 tggctgccag cactccgatc ctgcacggcg agtttggttc ctacccagcc catggcccca
      361 ggtttgccct caccctcacg acacaagccc tacacataca gcgactgcgc ccaaagccag
      421 aagcccggcc ccgagatggt ctagtccctc tggacgaggt ctcaggctgt ggcactctgc
      481 agagccgtag ccccgaagac actgcagcct acttctgcat ctacacctac ccacgtggcc
      541 ggcgtggggg ccggcgcaga gctactcgta ccttccgggc cgacggggcc gccacttatg
      601 tggagaatcg tgcagaggcc cagcgttggg caactgctct catgtgtctc ctccgaggag
      661 tgcctctgtc tggggaccag gaaatcaccc ctgaattgct gccccggaag cccaggctgc
      721 tcctattggt caatcctttt ggggggcggg gcctggcctg gcagcgctgt atggaccacg
      781 tggtgcccat gatctctgaa gctgggctgt ccttcaacct catacagaca gaacgacaaa
      841 accatgcacg tgagctggtg caggggttga gcctgagtga gtgggaaggc attgtcactg
      901 tgtccggaga tgggctgctt tatgaggtgc tgaatgggct cctcgaccgc ccagattggg
      961 aagacgctgt gcggatgccc attggtgtcc tcccctgtgg ttcgggcaat gcactagctg
     1021 gggcagttaa ccatcatggc gggtttgagc aaactgttgg tgttgacctg ttgctcaact
     1081 gctcgcttct tctctgccgg ggtggcagcc atcctctgga cctgctctct gtgacgctag
     1141 cctcaggatc ccgctgtttt tccttcctgt cagttgcctg gggattcttg tcagatgtgg
     1201 acattcacag cgagcgcttc agagccctgg gcagtgctcg attcacactg ggtgcagtgc
     1261 taggcctggc cacattgcat acctaccgtg gacgtctctc ctacctccct gctaccacag
     1321 aaccagcctt gcccatccca ggccatggtc tgccaagagc caagtcagaa ctagccttgg
     1381 ccccagcccc agccccagcc gccacccact cacctcttca tcgatctgtg tctgacctgc
     1441 ccctgcctct tccccagcct gccctggcct cccctggctc ccctgagccc ctgcctgacc
     1501 tgtccctcaa tggtggtggt ccagagctga ctggagactg ggggggagct ggggatgcac
     1561 ctttgtcccc agacccattg ctgccttcat cccccaacgc tttcaaaaca gctcagcttt
     1621 cacccatcgc cgaagggccc tcagaaatgc cagcatcagg gctgctgcct cccatccaca
     1681 atgctccaga agcctctacc tggggcccag cggaccacct gctccctccc ctgggctctc
     1741 cactgcccca agactgggtg acaatagagg gggagtttgt actcatgttg gccatcttgc
     1801 caagccacct ctgcgcagac ctgatggcag ccccacacgc gcgttttgac gatggtgtgg
     1861 tgcacctgtg ctgggtgcgg agcggcatct cacgggccgc acttctacga attttgctgg
     1921 ccatggaaca tggaaaccac ttcagcctgg gctgcccaca tctgggctat gctgcagcac
     1981 gtgccttccg ccttgagcca ctcacgcctc gtggggtgct cactgtagat ggggaattag
     2041 tagagtatgg gccaatacag gcacaggtgc atccaagtct cgccacactg ctcactgggc
     2101 ctgcaggtca aaagcctcga gcctgaatga gcccaaagca tgccaagttg atgggaccag
     2161 agccccatag gctaaggtct accttttata ggtagaagtg gggcctgaac tcagaactgc
     2221 aagggtagag agtgctccag accctcagtt cccagaggac cctagaggct cgagggtggg
     2281 atctgccttt cttgatgtcc aatgatgggg cctggaatgt atgagctagc aaggcttctt
     2341 cagcttactg tccagtcagg gtttcttctt gcctatttcg gtgcctctac ttgactggcc
     2401 aatcagccct tgaggggcag gttcccccag gtggtcccta gatttgcact aatgttcccc
     2461 tggccagtta ggggtgggat gttctgtgtc ttgtgtgtcc ctgtccctag tctaaaaagc
     2521 aattgaaaag gtctatgcaa taaaggtgtt gctttctctg gacctgca
//
LOCUS       NM_001107502            3233 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus leucine rich repeat and fibronectin type III
            domain containing 3 (Lrfn3), mRNA.
ACCESSION   NM_001107502 XM_001075911 XM_006228771 XM_218483
VERSION     NM_001107502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Lie,E., Ko,J.S., Choi,S.Y., Roh,J.D., Cho,Y.S., Noh,R., Kim,D.,
            Li,Y., Kang,H., Choi,T.Y., Nam,J., Mah,W., Lee,D., Lee,S.G.,
            Kim,H.M., Kim,H., Choi,S.Y., Um,J.W., Kang,M.G., Bae,Y.C., Ko,J.
            and Kim,E.
  TITLE     SALM4 suppresses excitatory synapse development by cis-inhibiting
            trans-synaptic SALM3-LAR adhesion
  JOURNAL   Nat Commun 7, 12328 (2016)
   PUBMED   27480238
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Swanwick,C.C., Shapiro,M.E., Vicini,S. and Wenthold,R.J.
  TITLE     Flotillin-1 mediates neurite branching induced by synaptic
            adhesion-like molecule 4 in hippocampal neurons
  JOURNAL   Mol Cell Neurosci 45 (3), 213-225 (2010)
   PUBMED   20600927
  REMARK    GeneRIF: Data reveal a flotillin-1 signaling pathway for
            hippocampal neurite branching that is regulated by synaptic
            adhesion-like molecule 4.
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Seabold,G.K., Wang,P.Y., Chang,K., Wang,C.Y., Wang,Y.X.,
            Petralia,R.S. and Wenthold,R.J.
  TITLE     The SALM family of adhesion-like molecules forms heteromeric and
            homomeric complexes
  JOURNAL   J Biol Chem 283 (13), 8395-8405 (2008)
   PUBMED   18227064
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 10, 2025 this sequence version replaced
            XM_006228771.4, NM_001107502.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158862.1, SRR21887620.793209.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1189              JAXUCZ010000001.1  94750864-94752052   c
            1190-2620           JAXUCZ010000001.1  94748363-94749793   c
            2621-3233           JAXUCZ010000001.1  94744319-94744931   c
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3233
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 3"
                     /db_xref="GeneID:308495"
                     /db_xref="RGD:1305567"
     exon            1..1189
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1068..1070
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="upstream in-frame stop codon"
     exon            1190..2620
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1206..3086
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3; synaptic adhesion-like
                     molecule 4"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3 precursor"
                     /protein_id="NP_001100972.1"
                     /db_xref="GeneID:308495"
                     /db_xref="RGD:1305567"
                     /translation="MAVLPLLLCLLPLAPASSPPQPATSSPCPRRCRCQTQSLPLSVL
                     CPGAGLLFVPPSLDRRAAELRLADNFIAAVRRRDLANMTGLLHLSLSRNTIRHVAAGA
                     FADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLED
                     LDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTT
                     IPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPP
                     ALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQG
                     RLLGNSSRARAFPNGTLELLVTEPEDGGTFTCIAANAAGEATAAVELTVGPPPPPQLA
                     NSTSCDPPRDGEPDALTPPSAASASAKVADTVAPTDRGVQVTEHGATAALVQWPDQRP
                     VPGIRMYQIQYNSSADDILVYRMIPADSRSFLLTDLASGRTYDLCVLAVYEDSATGLT
                     ATRPVGCARFSTEPALRPCAAPHAPFLGGTMIIALGGVIVASVLVFIFVLLLRYKVHG
                     VQPPGKAKATAPVSSVCSQTNGALGPVPSAPAPEPAAPRAHTVVQLDCEPWGPSHEPA
                     GP"
     sig_peptide     1206..1253
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     1254..3083
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /product="Leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3. /evidence=ECO:0000255.
                     /id=PRO_0000391358"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1)"
     misc_feature    1392..1457
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1392..1457
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    <1437..>1889
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <1437..>1889
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1455..1520
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 1"
     misc_feature    1458..1529
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1458..1529
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1527..1592
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 2"
     misc_feature    1530..1601
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1530..1601
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1599..1664
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 3"
     misc_feature    1602..1676
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1602..1676
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1674..1739
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 4"
     misc_feature    1677..1748
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1677..1748
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1746..1811
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 5"
     misc_feature    1749..1820
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1749..1820
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1818..1883
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: LRR 6"
     misc_feature    1821..1895
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1821..1895
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1929..1964
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1929..1964
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1950..>2048
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Leucine rich repeat C-terminal domain; Region:
                     LRRCT; smart00082"
                     /db_xref="CDD:214507"
     misc_feature    1950..>2048
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Leucine rich repeat C-terminal domain; Region:
                     LRRCT; smart00082"
                     /db_xref="CDD:214507"
     misc_feature    2091..2354
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    2091..2354
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    2142..2156
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    2142..2156
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    2181..2195
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    2181..2195
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    2220..2222
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B0BNK7.1); glycosylation site"
     misc_feature    2247..2249
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B0BNK7.1); glycosylation site"
     misc_feature    2250..2264
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    2250..2264
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    2292..2309
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    2292..2309
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    2331..2342
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    2331..2342
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    2349..2474
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2382..2384
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (B0BNK7.1); glycosylation site"
     misc_feature    2478..2711
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Fibronectin type III domain; Region: fn3;
                     pfam00041"
                     /db_xref="CDD:394996"
     misc_feature    2478..2711
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="Fibronectin type III domain; Region: fn3;
                     pfam00041"
                     /db_xref="CDD:394996"
     misc_feature    2823..2885
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /note="propagated from UniProtKB/Swiss-Prot (B0BNK7.1);
                     transmembrane region"
     exon            2621..3233
                     /gene="Lrfn3"
                     /gene_synonym="Salm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttaagc gcgagcacgc gcacggccct gggttcccgg cgaggaggcc gcgggagcac
       61 ccggacccgg cccgcctgcc cggcccccgc ccggcccccg ccccggcccc ggcgggggag
      121 gggtctctga acgcgacccc tcccccctgc gcccccgcct gccttgcggt gcccgggttc
      181 ccgcgtggcc ctgtctgtct gtccgtctgt ccgcgcccag gcctcgcccc accctggccc
      241 tagagctgcc ccgctgcccc cctacccgcc acagcagacc ccctctttct gggccagtct
      301 cctctacagg ccacgaaccc aatcgcgcca ttgctgcccc agaccgtcgg ccggcacccc
      361 gacatcgggg gcgcttgcag ccggcgatca gatccagata ttctgaaacc cccgagcgtg
      421 ggaccctgat ttgggatcag caccctgagc tcctgccatg gaaccctaag acccggacct
      481 tgaacctcaa tatctggggc tggaatcccg acatccgtct ctgggacccc aagatttgga
      541 aactgaaccc cacgattttg aagcatggac cccaatattt ggaccgggga ccccaagatt
      601 tggcatctaa ggccccaaat ttggagctga actctgaatt gtctggctga tacgttgaca
      661 tctgggagcg aattcccaaa tctatacctg ggaccccact atttggggag agaaaccctg
      721 ggatttaggc cttcaattcc aaggtttgaa ctgtgggatt ccgaggggcc tgaagtactt
      781 gctgcagacc tgagtgttga aatctggggc tagagacctc caagtcttga ctcagcacct
      841 actatctgaa caggatccca atttcgatgc caggactgga cgtgggcttc agaccctaaa
      901 cttccccatc tggctgtttg ttatctcaag tctggcactg agagagatct taaagagcca
      961 ctggggtctt gatttctaaa gctggactct agaggcccag tttttatgtt ctgggacccc
     1021 aagaatcaag tttggagacg ctgtaaccac agactggatc tgggacatga cagttccttc
     1081 cccaaggccc tggggacagg gaaggcttga ccagatgccc cctccagagt tctgacctca
     1141 cccccttgga gcctgaggac tctgctccct ggggtagctt ccagttcagg ccacccctgc
     1201 ccgcgatggc cgtccttcca ctactccttt gcctgctacc gctggccccc gcctcatctc
     1261 caccccagcc ggccacatcc agcccctgcc cccgccgttg ccgctgccag acccagtcgc
     1321 tgcccctaag cgtgttgtgc ccaggggcgg gccttctgtt cgtgccgcca tcactggatc
     1381 gccgcgcagc ggagttgcgc ctggcagaca acttcatcgc ggcagtgcgt cgtcgagacc
     1441 tggccaacat gacaggcctg ctgcatttga gcttatctag aaacaccatc cgccatgtgg
     1501 cagctggcgc cttcgccgac ctacgtgccc tgcgtgccct gcacctagat ggcaatagac
     1561 tgacctcgct gggcgagggt cagctgcgcg gcttagtcaa cttgcgccac ctcatcttga
     1621 gcaacaacca gctagcagcc ctggcagctg gtgcactaga cgactgtgcc gagaccctgg
     1681 aggacctcga tctctcttat aataaccttg agcagctgcc ctgggaggct ttgggtcgcc
     1741 tgggcaatgt caacacgttg ggccttgacc acaatttgtt ggcttcggtg cctgctggag
     1801 ccttttcccg cctgcacaag ttggcgcgac tggacatgac ctccaaccgc ctgaccacca
     1861 ttcctcctga cccactcttt tcccgcctgc cactgcttgc ccggcctaga ggctcaccag
     1921 cctctgctct ggtgctggcc ttcgggggaa accccctgca ttgcaactgt gaactggtgt
     1981 ggctgcggcg cctggctcgg gaagacgacc tcgaggcctg tgcctcacca cccgctctgg
     2041 ggggccgcta cttctgggcc gtgggtgagg aggagtttgt gtgtgagcca cccgtggtga
     2101 cccaccgctc acctcccctg gcagtgcccg caggtcggcc agctgccctg cgatgccggg
     2161 cagtagggga cccagagcca cgagtgcgtt gggtatcacc ccagggtcgg ctgctgggca
     2221 actccagccg tgcccgtgcc ttccctaatg ggaccctgga gctactggtc actgagccag
     2281 aagatggtgg tacattcact tgcattgcag ccaatgctgc tggcgaggcc actgctgctg
     2341 ttgagctgac cgtgggtccc cctccacctc cccagctagc caatagcacc agctgtgacc
     2401 ccccgcggga cggggaaccc gacgccctca ccccgccctc tgcggcttcg gcctccgcca
     2461 aagtggccga caccgtggcc cctaccgacc gtggtgtcca agtgactgag catggggcca
     2521 cagcagctct tgtccagtgg ccagatcaac ggcccgtccc aggcatccgc atgtaccaga
     2581 tccagtacaa cagctctgcc gacgacatcc tcgtttacag gatgatccca gcggacagtc
     2641 gctccttcct gctgactgac ctggcgtcag gccgtaccta tgatctgtgt gtgctcgcag
     2701 tttatgagga cagtgccacc gggctaacag ccacacggcc cgtgggctgc gctcggttct
     2761 ccacggagcc tgcacttcgg ccttgtgctg caccacacgc accgttcctg ggcggcacca
     2821 tgattattgc gctgggaggt gtcatcgtcg cttctgttct ggtcttcatt ttcgtgctac
     2881 ttctacgcta caaggtgcac ggagtccaac cgccgggcaa ggccaaggcc acagcacctg
     2941 tcagcagcgt ttgctcccag accaacggag ccctcggccc cgtgcccagt gcgcctgccc
     3001 ctgagcctgc tgcaccaagg gcccatactg tggtccaatt ggactgtgag ccctgggggc
     3061 ccagtcacga acctgcagga ccctagccga gggcccacct ctatggttcc tctggatcca
     3121 gacatccctc gggacctggc ctcagactca ccaaattgct cacggttttt aaaactctga
     3181 tggggagggt gtcggggtca ccggggcaca acaagaaagt cctatttttc taa
//
LOCUS       NM_001107498            4501 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus sterile alpha motif domain containing 4B
            (Samd4b), mRNA.
ACCESSION   NM_001107498 XM_001073474 XM_001073503 XM_001073537 XM_008759143
            XM_218384
VERSION     NM_001107498.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Amadei,G., Zander,M.A., Yang,G., Dumelie,J.G., Vessey,J.P.,
            Lipshitz,H.D., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     A Smaug2-Based Translational Repression Complex Determines the
            Balance between Precursor Maintenance versus Differentiation during
            Mammalian Neurogenesis
  JOURNAL   J Neurosci 35 (47), 15666-15681 (2015)
   PUBMED   26609159
REFERENCE   2  (bases 1 to 4501)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 10, 2025 this sequence version replaced
            XM_008759143.4, NM_001107498.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.2251.1,
                                           SRR22582416.745173.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000001.1  92855067-92855236   c
            171-573             JAXUCZ010000001.1  92840991-92841393   c
            574-1044            JAXUCZ010000001.1  92831111-92831581   c
            1045-1284           JAXUCZ010000001.1  92825399-92825638   c
            1285-1394           JAXUCZ010000001.1  92824946-92825055   c
            1395-1481           JAXUCZ010000001.1  92824709-92824795   c
            1482-1800           JAXUCZ010000001.1  92823834-92824152   c
            1801-1886           JAXUCZ010000001.1  92823297-92823382   c
            1887-2005           JAXUCZ010000001.1  92822806-92822924   c
            2006-2204           JAXUCZ010000001.1  92821471-92821669   c
            2205-2328           JAXUCZ010000001.1  92821225-92821348   c
            2329-2412           JAXUCZ010000001.1  92819217-92819300   c
            2413-4501           JAXUCZ010000001.1  92816922-92819010   c
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4501
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="sterile alpha motif domain containing 4B"
                     /db_xref="GeneID:308473"
                     /db_xref="RGD:1305597"
     exon            1..170
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            171..573
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    321..323
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="upstream in-frame stop codon"
     CDS             378..2441
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /codon_start=1
                     /product="protein Smaug homolog 2"
                     /protein_id="NP_001100968.1"
                     /db_xref="GeneID:308473"
                     /db_xref="RGD:1305597"
                     /translation="MMFRDQVGILASWFKGWNECEQTVALLSLLKRVTRTQARFLQLC
                     LEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYM
                     RLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRT
                     RPEPSYHSRQGSDEWGGPAELAPGEAGSGWQDKPPRENGHVPFHPSSSVPPAINSIGS
                     NANTGLPCQIHPSPLKRSMSLIPTSPQAPGEWPSPEELGARAAFTTPDHAPLSPQSSV
                     ASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQ
                     HLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIK
                     AYSVLQATPTAKDGGRGEPLLPGAEPPLTHPGSDKGTEAKDPPAAENYPPPPAPAPSD
                     SSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTET
                     QKKRLLSWKQQVLKLLRTFPRKAALDMQSYRQQKGWAFGSNSLPIAGSVGMGVARRTQ
                     RQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPS
                     QSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTD
                     KTSTI"
     misc_feature    1263..1451
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="SAM domain of Smaug subfamily; Region: SAM_Smaug;
                     cd09557"
                     /db_xref="CDD:188956"
     misc_feature    1263..1451
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="SAM domain of Smaug subfamily; Region: SAM_Smaug;
                     cd09557"
                     /db_xref="CDD:188956"
     misc_feature    order(1311..1313,1317..1322,1404..1406,1413..1421,
                     1440..1442,1446..1448)
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:188956"
     misc_feature    order(1311..1313,1317..1322,1404..1406,1413..1421,
                     1440..1442,1446..1448)
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:188956"
     exon            574..1044
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1284
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1394
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1481
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1800
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1886
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2005
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2204
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2328
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2412
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..4501
                     /gene="Samd4b"
                     /gene_synonym="RGD1305597"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgcgac ggcggcggcg gcggcggcgg tggtcggtgc gggaggaggg aggggagctc
       61 tcgggccaga gagggggcga cggcggtggc gacggcggcg gcagcggcgc tggtggcggc
      121 ggctgcctga ggaggcgcgg gtggcggcgg cggcggcgga ggccgaggcg gagcctggag
      181 aggtgtggct ggaccaagac ctcccctgat gtaagcaggc tccctcctcc cccccaccac
      241 ccgttgccac cacgccaggg gacatcctca agccctggcc cttaggggag aggtaacagg
      301 agcccagagc cgagaccatg tgacggcgct ggcccttgcc accgccgtcc cccaaccctg
      361 gccccaggcc tggcaccatg atgttccgag accaagtggg catcctcgct agctggttca
      421 agggctggaa tgagtgtgag cagacagtgg ccctgctgtc acttctgaag cgggtcaccc
      481 gtacccaagc ccgctttctg cagctctgcc tggagcactc actggcggac tgcaatgata
      541 tccacctgct ggagtcagag gccaacagtg ctgccatcgt cagccagtgg caacaggagt
      601 ccaaagagaa ggtggtgtcc ctcctgctgt cccatctgcc cctgctccag ccaggcaaca
      661 cagaggccaa gtctgagtac atgagactgc tgcagaaagt gctggcctac tccatcgaga
      721 gcaatgcctt cattgaagag agccgccagc tcctctcgta tgccctcatc cacccagcca
      781 ccacgctgga ggaccgcaat gcactagccc tctggctgag ccacctagaa gagcggctag
      841 ctagtggttt ccgcactcgg ccagagccct cctaccattc acgccagggc tcagatgaat
      901 ggggcggacc tgcagagctg gcccctggag aggcagggtc aggctggcag gacaagccac
      961 cccgggaaaa cggacacgta cccttccacc catccagctc tgtgccgccg gccatcaaca
     1021 gtattgggag caatgcaaac acaggtctcc cctgccaaat ccaccctagc ccactgaagc
     1081 gctccatgtc actcatcccc acgagccctc aggcccctgg tgagtggccg agtccagagg
     1141 agcttggggc ccgggctgct ttcaccacgc ccgaccacgc acccctctca ccgcagagca
     1201 gtgtggcttc ctctggcagt gagcagacgg aggagcaggg ctccagccgg aacacgttcc
     1261 aggaggatgg cagcgggatg aaagatgtac cctcgtggct caagagcctc cgcttgcaca
     1321 agtatgctgc tctgttttca cagatgagct atgaagagat gatgacccta actgagcagc
     1381 acctagagtc gcagaatgtc accaaaggtg cccggcacaa gatagccctg agcatccaga
     1441 agctgcgtga gagacagagc gtcctcaagt ccctagagaa ggatgtgctg gaaggtggca
     1501 atctgcggaa tgctctgcag gaactgcagc agatcatcat cactcctatc aaggcctaca
     1561 gtgtccttca ggctacccct actgccaagg atgggggtcg gggggagccg ctgctgccag
     1621 gtgctgagcc tcccctcacc caccctggat cagacaaggg cactgaggcc aaggaccctc
     1681 cagctgcaga gaactatcct cctccaccag ctccagcccc ctctgatagc agtgagccag
     1741 ccccagctcc cgtcgccgac ggagacatcc ccagccagtt tacacgggtg atgggcaaag
     1801 tatgcaccca gctgctggtg tcccgaccag acgaggagaa catcaccagt tacctccagc
     1861 tcatcgaaaa gtgcctgact catgaggctt tcacagagac acagaagaag cggctgctgt
     1921 cctggaagca gcaagtgctg aaactcctcc ggacattccc acgcaaagct gctctggaca
     1981 tgcagagcta ccggcagcag aagggctggg catttggctc caactcgctc cccatagctg
     2041 gctctgtggg gatgggtgtg gcccggcgga cccagcggca gttcccaatg cctcctcggg
     2101 cattaccacc tggcaggatg ggcctcctga gcccttctgg cattgggggt gtctctcctc
     2161 gacatgccct aaccagcccc agtcttgggg gtcagggccg acagaacctg tggtttgcca
     2221 atcctggagg cagcaacagc atgcccagcc agagccgcag ctctgtgcag cgcacccact
     2281 cgctcccagt tcactcgtca ccccaggcta ttctcatgtt ccctccagac tgcccggtac
     2341 ctgggcctga cctggagatc aatcctaccc tggagtctct gtgtctgagc atgacagaac
     2401 acgccttggg tgatgggaca gacaaaacct ccaccatctg acgggaccca cagcccagcg
     2461 cacccatagg ctccctgggc ggcgggcggg gccatccccc aacaggcttc tcctcggcag
     2521 cgagagggtg ggctggcgca gctatacatt ctgatatttt tctactcatc ctcttaactt
     2581 ttgtttaaca ttggcacacg ccttgctcac tcccaggccc attgagggat ctcagctgag
     2641 gccagggaca gagaaggcag ccagaggcaa ggactagcca gactgcctgc cccttccctc
     2701 ctaaatcccc tactggcccc ctcctacccc tgcctccttc agactgctga cacctgtcct
     2761 tccccaagag agcagacttc ctcagagaca aactgacagc caccttgtgc agcctgccct
     2821 tcagacacat gacagtgggg gaatgagcag tgtggagccc atctccctta cccccaaccc
     2881 ttcatcattc ctaccatttc ccaggacagg caccaccttc ctcttttttt tttttttttt
     2941 ttttcttgcc ctgtttatca gaggttctct acaattaatt tcttaggcct atttaagata
     3001 catatttata tagttcttaa cggtttttct ctgatcattc cctgtcattt ttagaatccc
     3061 caggcctctc tctgagccag gacagtggca gggggagcct gaactttatg aggagagggc
     3121 agagccccct cttgcagacc ccctgccctt ccccatccca gccccggctc ccagatgcag
     3181 aggttgaagg tgggcagccc caggcccaca gtgaggtcag gaagtctgtt gccttaatgt
     3241 ccctttcccc caccaacata acccttctct gttccccagg tctattggca agacttgtgg
     3301 gtaggaacca gggaaggagg gttgttgggt ttttgtttcc ttgcctaccc tctctttctg
     3361 tcagcctttc ctacccccat tatgtcatga cctcatgtaa gtggaacact attatcataa
     3421 cccagaggtg cagcccagcc tgagtcacat aaaccctcta ctccctgttc ttgatgaggg
     3481 ctggtgctgg ggcccaggtg gagggaggga attagggatt caggctgtgg ggaagccagg
     3541 gtcccctatt ccaaactcct ctttccccct caacctatac cctcattggg acattctcaa
     3601 gcttttcaca cgaaaaggaa aaaaatgtta tttttagata cattttatga ataacttttg
     3661 ttatgaatat ggctggtaac cattgtgtat gttattaaag atacaaaatg ttgggaaaaa
     3721 aacaaaacca aaaaaaaaaa aaaaaaggaa aaaaggaaaa aaagaaagcc ttccctgcac
     3781 tatcagccca tccccccaga ccttgcccct gcctcctggg ctgtggacct cccctgcttt
     3841 gagcccaggg agggagaaga agccaggggg tagtgtggcc ctggggacct gcctgtggtc
     3901 cccaccacct ctcccagtgc cgggctgggc ggggtgtcag gtgtatttat gtacctcttg
     3961 cacactcatc aacctatgca agtccccacc ccggccctcc aggtttctgt gcctttgctc
     4021 attccccctc ttgactccta ggcttctccg gcccctccca ctaacagtgg gaagtggggt
     4081 gaaaggccac ctgtttggaa taagcagggt gtccctctca tgggaccctc acctccacaa
     4141 gccggtctag tcttgtcttg ttcacttccc atcagggtta ctgactctgc ctggcactgg
     4201 aaggtgatga gggatatcct ccccaagagg gaggtgagag cttcccaccc acctgacagc
     4261 agagtgcagg acgcaggcgg ccctactctg acaggcagga ccctgaccct cccaccctcc
     4321 atccccctct gtggtttcac cctaccctgc ccacttctgt ccccagcccc actggcagaa
     4381 tcagctttga gtaactgtac atttttctcg ctgttggaga agacttattt gttggagttt
     4441 caattgttaa tggtctgggc ttattttgga aaacaaaaaa acaaaaacaa aaaacaaaaa
     4501 a
//
LOCUS       NM_001437877            4877 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus prostaglandin F receptor (Ptgfr), transcript
            variant 2, mRNA.
ACCESSION   NM_001437877 XM_006233486
VERSION     NM_001437877.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4877)
  AUTHORS   Fukuda,M., Aoki,T., Manabe,T., Maekawa,A., Shirakawa,T.,
            Kataoka,H., Takagi,Y., Miyamoto,S. and Narumiya,S.
  TITLE     Exacerbation of intracranial aneurysm and aortic dissection in
            hypertensive rat treated with the prostaglandin F-receptor
            antagonist AS604872
  JOURNAL   J Pharmacol Sci 126 (3), 230-242 (2014)
   PUBMED   25341845
  REMARK    GeneRIF: Prostaglandin F-receptor antagonist AS604872 exacerbates
            vascular inflammation in hypertensive animals, facilitating
            intracranial aneurysm formation and aortic dissection.
REFERENCE   2  (bases 1 to 4877)
  AUTHORS   Anadol,E., Kanca,H., Yar,A.S., Helvacioglu,F., Menevse,S.,
            Calguner,E. and Erdogan,D.
  TITLE     Prostaglandin F receptor expression in intrauterine tissues of
            pregnant rats
  JOURNAL   J Vet Sci 15 (1), 125-131 (2014)
   PUBMED   24136214
  REMARK    GeneRIF: There was an increase rat prostaglandin F receptor
            expression in rat uterus with advancing gestation, a marked
            elevation of expression at term, and a concominant decrease during
            the postpartum period.
REFERENCE   3  (bases 1 to 4877)
  AUTHORS   Ueno,T. and Fujimori,K.
  TITLE     Novel suppression mechanism operating in early phase of
            adipogenesis by positive feedback loop for enhancement of
            cyclooxygenase-2 expression through prostaglandin F2alpha receptor
            mediated activation of MEK/ERK-CREB cascade
  JOURNAL   FEBS J 278 (16), 2901-2912 (2011)
   PUBMED   21668646
REFERENCE   4  (bases 1 to 4877)
  AUTHORS   Suzuki-Yamamoto,T., Toida,K., Sugimoto,Y. and Ishimura,K.
  TITLE     Colocalization of prostaglandin F(2alpha) receptor FP and
            prostaglandin F synthase-I in the spinal cord
  JOURNAL   J Lipid Res 50 (10), 1996-2003 (2009)
   PUBMED   19429887
  REMARK    GeneRIF: Data found that FP localizes in neuronal somata and
            dendrites but not in ependymal cells, tanycytes, or endothelial
            cells. Immunohistochemical analysis of serial sections showed the
            colocalization of FP and PGFS I.
REFERENCE   5  (bases 1 to 4877)
  AUTHORS   Almirza,W.H., Dernison,M.M., Peters,P.H., van Zoelen,E.J. and
            Theuvenet,A.P.
  TITLE     Role of the prostanoid FP receptor in action potential generation
            and phenotypic transformation of NRK fibroblasts
  JOURNAL   Cell Signal 20 (11), 2022-2029 (2008)
   PUBMED   18703136
  REMARK    GeneRIF: Activity of PGF(2alpha) by putative pacemaker cells
            underlies the generation of calcium action potentials in normal rat
            kidney monolayers.
REFERENCE   6  (bases 1 to 4877)
  AUTHORS   Yonekura,H., Sakurai,S., Liu,X., Migita,H., Wang,H., Yamagishi,S.,
            Nomura,M., Abedin,M.J., Unoki,H., Yamamoto,Y. and Yamamoto,H.
  TITLE     Placenta growth factor and vascular endothelial growth factor B and
            C expression in microvascular endothelial cells and pericytes.
            Implication in autocrine and paracrine regulation of angiogenesis
  JOURNAL   J Biol Chem 274 (49), 35172-35178 (1999)
   PUBMED   10575000
REFERENCE   7  (bases 1 to 4877)
  AUTHORS   Olofsson,J.I., Leung,C.H., Bjurulf,E., Ohno,T., Selstam,G., Peng,C.
            and Leung,P.C.
  TITLE     Characterization and regulation of a mRNA encoding the
            prostaglandin F2alpha receptor in the rat ovary
  JOURNAL   Mol Cell Endocrinol 123 (1), 45-52 (1996)
   PUBMED   8912810
REFERENCE   8  (bases 1 to 4877)
  AUTHORS   Orlicky,D.J.
  TITLE     Negative regulatory activity of a prostaglandin F2 alpha receptor
            associated protein (FPRP)
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 54 (4), 247-259 (1996)
   PUBMED   8804121
REFERENCE   9  (bases 1 to 4877)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
REFERENCE   10 (bases 1 to 4877)
  AUTHORS   Kitanaka,J., Hasimoto,H., Sugimoto,Y., Negishi,M., Aino,H.,
            Gotoh,M., Ichikawa,A. and Baba,A.
  TITLE     Cloning and expression of a cDNA for rat prostaglandin F2 alpha
            receptor
  JOURNAL   Prostaglandins 48 (1), 31-41 (1994)
   PUBMED   7972878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006233486.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.7082.1,
                                           SRR26643289.8015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000002.1  243426029-243426204 c
            177-1047            JAXUCZ010000002.1  243423769-243424639 c
            1048-4877           JAXUCZ010000002.1  243391590-243395419 c
FEATURES             Location/Qualifiers
     source          1..4877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..4877
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F receptor"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
     exon            1..176
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     exon            177..1047
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..207
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="upstream in-frame stop codon"
     CDS             250..1350
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="PGF receptor; prostanoid FP receptor; PGF2-alpha
                     receptor"
                     /codon_start=1
                     /product="prostaglandin F2-alpha receptor"
                     /protein_id="NP_001424806.1"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
                     /translation="MSINSSKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSN
                     SLAIAILMKAYQRFRRKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFD
                     QSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLFHSTKITSKHVKMILSGVC
                     MFAVFVALLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLALGISFS
                     CNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAING
                     NNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWE
                     LSSIKNSLKVAAISESPAAEKENQQASSEAGL"
     misc_feature    259..261
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P43118.1); glycosylation site"
     misc_feature    304..306
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P43118.1); glycosylation site"
     misc_feature    328..1197
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F2-alpha receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_FP; cd15145"
                     /db_xref="CDD:320273"
     misc_feature    328..1197
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F2-alpha receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_FP; cd15145"
                     /db_xref="CDD:320273"
     misc_feature    331..411
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320273"
     misc_feature    331..411
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320273"
     misc_feature    343..414
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    445..525
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320273"
     misc_feature    445..525
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320273"
     misc_feature    457..519
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    order(511..513,520..525,571..588,592..597,604..606,
                     739..741,745..759,838..840,847..855,859..867,871..876,
                     1033..1035,1042..1047,1051..1056,1063..1065,1093..1098,
                     1102..1110,1117..1119,1126..1131)
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320273"
     misc_feature    order(511..513,520..525,571..588,592..597,604..606,
                     739..741,745..759,838..840,847..855,859..867,871..876,
                     1033..1035,1042..1047,1051..1056,1063..1065,1093..1098,
                     1102..1110,1117..1119,1126..1131)
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="putative ligand binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:320273"
     misc_feature    571..663
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320273"
     misc_feature    571..663
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320273"
     misc_feature    577..642
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    697..765
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320273"
     misc_feature    697..765
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320273"
     misc_feature    706..774
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    838..927
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320273"
     misc_feature    838..927
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320273"
     misc_feature    844..921
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    973..1065
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320273"
     misc_feature    973..1065
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320273"
     misc_feature    1000..1050
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     misc_feature    1096..1173
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320273"
     misc_feature    1096..1173
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320273"
     misc_feature    1105..1170
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="propagated from UniProtKB/Swiss-Prot (P43118.1);
                     transmembrane region"
     exon            1048..4877
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgctctg gagtccagga cacaataggt cctgcctgtg attcagcgct cagaagggtc
       61 ctagggaggc ggtggaacca ggggttgcgg ctgcgcgggg ctggttgcgc catggaacac
      121 cgggctccgc gctcttctgc tccggacaca gccactcgat ggcccaggat gccgagatgt
      181 ctgcacttcg aggctgcaca gtcgtgacag agagatgact tgagggggac ggcgtttatc
      241 tccacaacga tgtccataaa cagttccaag cagccggcgt cctctgcagc tggactcatc
      301 gccaacacga cttgccagac ggagaaccgg ctttcagtgt tcttttcaat aatcttcatg
      361 acggtgggga ttgtatctaa cagcctggcc attgccatcc tcatgaaggc atatcagaga
      421 tttagacgga agtcgaaggc ttctttcctg ctcttggcta gtggcctggt gatcacagac
      481 ttcttcggcc acctcatcaa cggagggata gctgtcttcg tatacgcttc tgataaagac
      541 tggatccgct tcgatcaatc gaacatcctg tgcagtgttt ttgggatctc catggtgttc
      601 tctggcttgt gcccactttt cctgggcagt acgatggcca ttgagaggtg catcggggtc
      661 accaaccctc tattccactc tacaaagatc acgtctaagc atgtgaaaat gatactgagc
      721 ggtgtgtgca tgtttgctgt cttcgtggcc ctgttgccca tccttggaca ccgagattat
      781 caaatccaag catccagaac ttggtgcttc tacaacacag agcacatcga agactgggaa
      841 gacaggttct atctcttgtt cttttcttcc ctgggactct tagctctcgg catctcattc
      901 tcgtgcaacg ccgtcacggg agtcacactt ttgagagtga agtttagaag tcagcagcac
      961 aggcaaggca ggtctcacca cctggagatg gtcattcagc tcctggccat aatgtgtgtc
     1021 tcctgcgtct gctggagtcc ctttctggtg acgatggcca acattgcaat caatggaaat
     1081 aattccccag tgacctgtga gacgacgctc tttgctctcc gaatggcaac ctggaaccag
     1141 atattagacc cctgggtcta cattctgcta cggaaggctg tccttaggaa cctgtacaag
     1201 cttgccagtc gctgctgtgg agtgaacatc atcagcttgc acatctggga actcagctcc
     1261 atcaagaatt ccttaaaggt tgctgctatc tctgagtcac cggctgcaga gaaggagaat
     1321 cagcaagcat ctagtgaggc tggactgtaa gtcaatgcac agctagaaga aagttatggg
     1381 aacttccgaa acatcttacc tgaccagact cagagcataa ctggaacact tggacctctg
     1441 tgtgtagttc aggagtacac tggtcagaca aagcttctga cttttgttat gctggctgct
     1501 gcatggttgt gcattttcat ttgttggtgt caacaggaga ttcaacatgg tggagttaag
     1561 tagagtacac attttatctg cgtgacttat gtttttggaa taaatgaatc tgttgaggcc
     1621 ctgtgccttt atttgaccta tttttccaag caccttaatg ctacctgcac cgtgacatgg
     1681 ccatttgagg agcactgact tgcagacaaa gcttaaagta acacaagact ttttgtgttt
     1741 gtgtgtgcag ctctgctctg tttaccaacc cacgtgtcct caatgtctgc atgaccatga
     1801 catctgagtc tcgtggtgac tttgatggcc actatgtagg cagctcagct tgacattgtg
     1861 gggctgatga ggataatcat tcttgtcaca actcacatgt gtggttgctt gcatttgttg
     1921 ttgtgaaggt caattatttt ttccacattg gctgtcctcc tataaagtca taggttttca
     1981 gtgtctaagt aatccccctt tcctctgaaa attgtagagg aatacaggct ttatcttagc
     2041 acagattcag ctcatgatag catatcataa gccctattgt ggatgatgca aacattgaaa
     2101 tcccacttac acatgccaag aacatggcag acattgcttt acctgagcta tcatttctgt
     2161 gtcagagaat aaaaaacgat caagacacat tcgaagtctc ttggagctat tgtgtttctg
     2221 ccttacacac acaggcataa gggagttctg ttaacagtaa tttcactaaa taagttgaac
     2281 cacacttcca aaagcctgtg ttatcagtga ggagtggaaa gatctgaaat tagccaggag
     2341 ttgggatcca ctgttgtggt taacccgagg ctaagggaca agattctgtc gccaagtttc
     2401 ccaatcttaa ttcacacttc tcctttgtat aatttaacac aaagatactc aatttcagta
     2461 atcactctaa acattagttc catcagtgac tacggttagt ggttatattt tataaagaaa
     2521 tgtattttca tatttaaaaa attcctttct tttatcgttt gtctttattt aaaaatttct
     2581 atttttttct ttgctatgtg tatgagtgtt tcacccgaat gtatttccga gcattacgta
     2641 ccttcctaga acttacttaa accagaaaag gacatcgggt ccttacagat ggttataagc
     2701 taccatgtgg atactaggaa ttgagcccag gttctctgga agagcagctg tagagagaat
     2761 tttaatccag caatttgtga attcaataga cttaaaatag tacctccaac atggtttctc
     2821 tggcaaaaga tcacatccga agagcttcta ggtttatatg atctggcttg aatgcagaca
     2881 ttctctggat tatagtacaa tctggctgta acacagacac acccttagta cacaccttta
     2941 atccctaaca gtgaaggaaa gttagtttgt agaaggaagt agtcactttt gaaatcgatg
     3001 tccagttgag ggtcagacag agtgacgaat cagagaaagt tttgacagaa tgagttagag
     3061 aaaggatgtg ctcaattcac gtgagaacag tacggaaaga gaggatgccg aaaaggggag
     3121 agagagagag agagagagag agagagagag agagagagag agagggagga agaaggagga
     3181 ggaggaagag gaggaggagg aggatgaaga taaggaggaa gaggaagaag ggaggagtga
     3241 gaggaggggg aggaggagga gggactgcgg tgtgtgttta tggtaccagg acagatttat
     3301 atagtttggc tgtagggaga acaagctgga tacaggtgaa gacagagcaa accaaaaaat
     3361 gagaaggagc cagaagagta gaccttattg acaaagttcg tatgaggcca agcaagcaat
     3421 caggcagaag tggagagaag ccagactgaa tcagtcagct tggaagatta gattgtttgg
     3481 aggatagacg ctttcaggcc taggcctagg gataattaga acagagaaag aagtgctctg
     3541 ggctcagcct aagctgtgta tccacagagc tagaaaacag gtttcatccc atcccttcat
     3601 ctgaggaaat aaaggcatca ttttcaagtg ctgcttaact gctgagccat ctctccagcc
     3661 tttcaaaact gtttttatct gtaaaaataa ttttggattc taggaatcct gtaaactcaa
     3721 caaaatagta tttttaaaaa cctctgcttt tgattggtag cttacattgg atatgattac
     3781 tgcttttggt aaattctcat tagtaaatta aaagaaatta agcaaacagc ctcgttgaag
     3841 acttaaagaa aattatttgt agtgatttga aaggagtaca cactatcatg tgataatctt
     3901 aatttaaagg caagtgatca atcacacagt tgattcttat gtagagaata tgtcagagaa
     3961 tagacaacaa tttttggtgt aaatttagca cggggttgta aagaatgtgc ccagtttaag
     4021 tgtaagctga tacctatatg tgggttattg tgatgtagat atgtatacat atatgtatgt
     4081 aagttcccct gtgcatgcat gtgtttatga atatgtgtgt atatgtatgt gtatatatgt
     4141 ataatgcata tgattgtaaa aggcattaca atttatgatt aatgttacat tacataagtg
     4201 ttatcatttt taacttcaag agtactcaaa gtttggaaaa ccatttggtc acttcacgca
     4261 ctttcagagc agatttcttt cctacagcaa taagatgttg ctatctcaca aactgaggct
     4321 caaagaacca aatctctgtc tttcctaatt atagtttgca taactctgca atgaacattg
     4381 gcatgtattc caactgagga aaggtagtaa gaaggaactt cgagactcca ggtctcttca
     4441 tagagcctct gatacagaca caattgttct tctacctact ttgatgtcta caatgagacc
     4501 atcttttaac atcatgctgt gctgaaggca aggctctggg aagagccaag gagttactca
     4561 gtgcatattc tggaagattt atccatgcta cttgagcata ccgtttaggc aaaaaaaaaa
     4621 aaaacccaaa aaaacagaag aacaaaacaa aatgaaaaac tgatcttaag atgaggataa
     4681 acccacagtg taaatataaa aaattgaaaa agtttcatgt tatacctgac tctaaaattc
     4741 tgtttgttat agtgcctgtt gtacctagtt tactgtacag tgagcgatag agaatgtgct
     4801 cactgataac ttccataggg ctgagtagaa gtgtgctttt tcttagccct taaaataaag
     4861 agtacaagta gtgccaa
//
LOCUS       NM_001437817            6906 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus SNF2 histone linker PHD RING helicase (Shprh),
            transcript variant 1, mRNA.
ACCESSION   NM_001437817 XM_006227639
VERSION     NM_001437817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6906)
  AUTHORS   Zeman,M.K., Lin,J.R., Freire,R. and Cimprich,K.A.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   2  (bases 1 to 6906)
  AUTHORS   Motegi,A., Liaw,H.J., Lee,K.Y., Roest,H.P., Maas,A., Wu,X.,
            Moinova,H., Markowitz,S.D., Ding,H., Hoeijmakers,J.H. and Myung,K.
  TITLE     Polyubiquitination of proliferating cell nuclear antigen by HLTF
            and SHPRH prevents genomic instability from stalled replication
            forks
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12411-12416 (2008)
   PUBMED   18719106
REFERENCE   3  (bases 1 to 6906)
  AUTHORS   Motegi,A., Sood,R., Moinova,H., Markowitz,S.D., Liu,P.P. and
            Myung,K.
  TITLE     Human SHPRH suppresses genomic instability through proliferating
            cell nuclear antigen polyubiquitination
  JOURNAL   J Cell Biol 175 (5), 703-708 (2006)
   PUBMED   17130289
REFERENCE   4  (bases 1 to 6906)
  AUTHORS   Unk,I., Hajdu,I., Fatyol,K., Szakal,B., Blastyak,A., Bermudez,V.,
            Hurwitz,J., Prakash,L., Prakash,S. and Haracska,L.
  TITLE     Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent
            polyubiquitylation of proliferating cell nuclear antigen
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18107-18112 (2006)
   PUBMED   17108083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced XM_006227639.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.54.1, SRR26643292.53.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000001.1  7349201-7349314
            115-767             JAXUCZ010000001.1  7351308-7351960
            768-897             JAXUCZ010000001.1  7355004-7355133
            898-1116            JAXUCZ010000001.1  7357118-7357336
            1117-1195           JAXUCZ010000001.1  7359535-7359613
            1196-1346           JAXUCZ010000001.1  7360560-7360710
            1347-1455           JAXUCZ010000001.1  7362013-7362121
            1456-1709           JAXUCZ010000001.1  7363203-7363456
            1710-2387           JAXUCZ010000001.1  7364754-7365431
            2388-2639           JAXUCZ010000001.1  7366890-7367141
            2640-2718           JAXUCZ010000001.1  7368083-7368161
            2719-2882           JAXUCZ010000001.1  7370243-7370406
            2883-3139           JAXUCZ010000001.1  7370509-7370765
            3140-3261           JAXUCZ010000001.1  7372111-7372232
            3262-3350           JAXUCZ010000001.1  7379066-7379154
            3351-3443           JAXUCZ010000001.1  7381878-7381970
            3444-3551           JAXUCZ010000001.1  7384115-7384222
            3552-3694           JAXUCZ010000001.1  7385336-7385478
            3695-3868           JAXUCZ010000001.1  7386175-7386348
            3869-3931           JAXUCZ010000001.1  7386633-7386695
            3932-4157           JAXUCZ010000001.1  7387666-7387891
            4158-4301           JAXUCZ010000001.1  7388633-7388776
            4302-4403           JAXUCZ010000001.1  7389892-7389993
            4404-4475           JAXUCZ010000001.1  7391376-7391447
            4476-4664           JAXUCZ010000001.1  7399780-7399968
            4665-4757           JAXUCZ010000001.1  7414199-7414291
            4758-4844           JAXUCZ010000001.1  7414926-7415012
            4845-5023           JAXUCZ010000001.1  7415632-7415810
            5024-5104           JAXUCZ010000001.1  7419874-7419954
            5105-6906           JAXUCZ010000001.1  7421003-7422804
FEATURES             Location/Qualifiers
     source          1..6906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..6906
                     /gene="Shprh"
                     /note="SNF2 histone linker PHD RING helicase"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
     exon            1..114
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    111..113
                     /gene="Shprh"
                     /note="upstream in-frame stop codon"
     exon            115..767
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..5201
                     /gene="Shprh"
                     /EC_number="2.3.2.27"
                     /note="SNF2 histone linker PHD RING helicase, E3 ubiquitin
                     protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SHPRH"
                     /protein_id="NP_001424746.1"
                     /db_xref="GeneID:308282"
                     /db_xref="RGD:1310342"
                     /translation="MSSRRKRAPPMKVDEERQQQLRWNMHEDLRNEPLSLTEEERACW
                     DADSSDCIIIDDDPPEGAAHRDKKRCTESVSILNSTEKETPLSVALNVTISPHPSDDS
                     WKAFLGDFVLQLLPEESLVEHFSERTFTLMSSESSSQLLIYVHSECNNVEKEENVLKG
                     PASIYGKGIRVESSFSSDMLQDLAWLQKRRGIKLYQRPEGTHTIKVRIYLLEAGLTRL
                     DFMSDAGSRMKKFNQLLKRVMGKLYSLSIPDVLEEDEEESESEPEGQDIDELYQFVKR
                     THQQEAKSVQVDVQHPALIPVLRPYQREAVNWMLQQEQFRSTPAGDNSLHFLWREIVT
                     PDGLNLYYNPYTGCIIRDFPHAGPQLLGGILADEMGLGKTVEVLALILTHTRQDVRQD
                     ALTLPEGKVVNYFIPTHCPRGKVKSREIQNTECEPKEKVHCPPTRVMILTAVKEMNGK
                     KGVSILSIYKYVSSTFRYDVQRNRSLLKRMLKCLIFEGLVKQIKGRGFSGTFTLGKNY
                     KEDVFDKTKKQAVGSPQKIEKELRKSVNKDTDSEYMPSDIYDDDNDNDDDDDDDPYYY
                     YCKARKSRKLKKKPVLLTKKEKGQPVNLDSQVEAPAAGDCASADAHVSESTCVSENRQ
                     IQDAEDCVESPSPAAMELAQSNTASFCETPDYRFECICGEFDQIGRKPRVQCLKCHLW
                     QHAKCVNYEEKNLKVKPFYCPHCLVAMEPVSTRATLIISPSSICHQWVDEINRHVRSS
                     SLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELNYVDIPHSNSEDGRRLRNQK
                     RYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCVSGTPVQRGLED
                     LFGLVVFLGIEPYCVKHWWIRLLYHPYCKKNPQHLYSFIAKIMWRSAKKDVIDQIQIP
                     PQTEEMHWLHFSPVERHFYHRQHEVCCQDAVVKLRKISDWALKLSSLDRRTVSSILYP
                     LLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAHRQLVCALNGLA
                     GIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLVAKHPGIPPT
                     LRDGRLEEEAKQLREHYMSKCNTEVAEAQQALQPVQQSIRELQRKVHSGSPWWLNVVH
                     RAMEYAVDEELVQRVRNEISSNYKHQTDKLSMSEKFRDCRGLQFLLTTQMEELHKFQK
                     LVREAVKKLEKPPSRDVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSNTVK
                     GQTAIFEEMIEDEEGLVDDRVPTTTRGLWAVSETERSMKAILSFARSHRFDVEYIDEG
                     SVSMDLFEAWKKEYKLLHEYWMTLRNRVSAVDELAMATERLRVRHPKEPKPNPPVHHI
                     IEPHEVEQNRIKLVNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGINPEPCPICAR
                     QLGKQWAVLTCGHCFCNECTSIIIEQYSVGSHRSSIKCAICRQTTSHKEVSYVFTSEK
                     ANQEDDIPVKGSHSTKVEAVVRTLMKIQLKDPGAKALVFSTWQDVLDIISKALTDNNM
                     GFTQISRIKTFQENLSAFKYDPQINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHE
                     LQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTSSSGKHSEASALTVA
                     DLADLFTKESEELE"
     misc_feature    603..>1298
                     /gene="Shprh"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    603..>1298
                     /gene="Shprh"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     Region: HepA; COG0553"
                     /db_xref="CDD:440319"
     misc_feature    1044..>1394
                     /gene="Shprh"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:475120"
     misc_feature    1044..>1394
                     /gene="Shprh"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:475120"
     misc_feature    1257..1277
                     /gene="Shprh"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     misc_feature    1257..1277
                     /gene="Shprh"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     misc_feature    1452..1658
                     /gene="Shprh"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    1452..1658
                     /gene="Shprh"
                     /note="linker histone H1 and H5 family; Region:
                     Linker_histone; pfam00538"
                     /db_xref="CDD:459846"
     misc_feature    2127..2267
                     /gene="Shprh"
                     /note="PHD finger found in E3 ubiquitin-protein ligase
                     SHPRH; Region: PHD_SHPRH; cd15547"
                     /db_xref="CDD:277022"
     misc_feature    2127..2267
                     /gene="Shprh"
                     /note="PHD finger found in E3 ubiquitin-protein ligase
                     SHPRH; Region: PHD_SHPRH; cd15547"
                     /db_xref="CDD:277022"
     misc_feature    order(2127..2129,2166..2180,2190..2192,2250..2252)
                     /gene="Shprh"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277022"
     misc_feature    order(2127..2129,2166..2180,2190..2192,2250..2252)
                     /gene="Shprh"
                     /note="putative histone H3 binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:277022"
     misc_feature    <2253..2858
                     /gene="Shprh"
                     /note="DEXQ-box helicase domain of SHPRH; Region:
                     DEXQc_SHPRH; cd18070"
                     /db_xref="CDD:350828"
     misc_feature    <2253..2858
                     /gene="Shprh"
                     /note="DEXQ-box helicase domain of SHPRH; Region:
                     DEXQc_SHPRH; cd18070"
                     /db_xref="CDD:350828"
     misc_feature    4434..4595
                     /gene="Shprh"
                     /note="RING finger, HC subclass, found in SNF2
                     histone-linker PHD finger RING finger helicase (SHPRH) and
                     similar proteins; Region: RING-HC_SHPRH-like; cd16569"
                     /db_xref="CDD:438231"
     misc_feature    4434..4595
                     /gene="Shprh"
                     /note="RING finger, HC subclass, found in SNF2
                     histone-linker PHD finger RING finger helicase (SHPRH) and
                     similar proteins; Region: RING-HC_SHPRH-like; cd16569"
                     /db_xref="CDD:438231"
     misc_feature    4671..5048
                     /gene="Shprh"
                     /note="C-terminal helicase domain of the SNF family
                     helicases; Region: SF2_C_SNF; cd18793"
                     /db_xref="CDD:350180"
     misc_feature    4671..5048
                     /gene="Shprh"
                     /note="C-terminal helicase domain of the SNF family
                     helicases; Region: SF2_C_SNF; cd18793"
                     /db_xref="CDD:350180"
     misc_feature    order(4758..4763,4785..4787,4902..4904,4965..4970)
                     /gene="Shprh"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350180"
     misc_feature    order(4758..4763,4785..4787,4902..4904,4965..4970)
                     /gene="Shprh"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350180"
     misc_feature    order(4920..4925,4929..4931,4998..5000,5007..5009)
                     /gene="Shprh"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350180"
     misc_feature    order(4920..4925,4929..4931,4998..5000,5007..5009)
                     /gene="Shprh"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350180"
     exon            768..897
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1116
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1195
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1346
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1455
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1709
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..2387
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2639
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2718
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2882
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3139
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3261
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3350
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3443
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3551
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3694
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3868
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3931
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4157
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4301
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4403
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4475
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4664
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4757
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4844
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            4845..5023
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..5104
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
     exon            5105..6906
                     /gene="Shprh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgcagc gcgcgtgcgc aactccggca ggtgtgtgaa gcgactgtcc gcccgggatc
       61 tgcaggctcc gaggagggcc ggtcctcgcg actggtgctc gtatagcggt tgagaattca
      121 cgtttaccaa ccaagaaagg gaaagctcga ggatgagtag ccgaaggaaa cgtgctcccc
      181 cgatgaaggt ggatgaagaa aggcagcagc agcttcgctg gaacatgcac gaggacctga
      241 ggaatgagcc gctcagcttg actgaggaag agcgggcctg ctgggatgca gactcctccg
      301 attgcatcat catagatgat gaccctcccg aaggtgcagc tcacagagat aagaagaggt
      361 gtacagagtc tgtgagcatc ttaaactcca ctgaaaaaga gacccctctg tccgtggcct
      421 tgaatgttac catttctccc catccttccg atgattcttg gaaagcgttt ctgggagatt
      481 ttgtgcttca gcttctccct gaagagagtt tagttgaaca tttttctgaa aggactttta
      541 cgttgatgag ttcagagtca agcagtcagc tcctgatcta tgttcattca gaatgtaaca
      601 atgtggagaa agaagaaaac gtacttaaag gaccagcaag tatctatggc aagggtattc
      661 gagtggaatc ctccttcagt agtgacatgt tacaggattt ggcctggcta cagaagagaa
      721 gaggaataaa actctaccag cgaccagaag gaactcatac gatcaaggtt agaatttacc
      781 tcttggaagc tggcctgaca agactagact tcatgagtga tgcaggctcc agaatgaaaa
      841 agttcaatca gctcctgaag agagtgatgg gaaagttata cagtctcagt attccagatg
      901 tgttggaaga agatgaggag gaatcagaga gtgagccaga gggccaggac attgatgagc
      961 tctatcagtt tgtgaagcga acacaccagc aagaggcaaa gtcagtccaa gtggatgtcc
     1021 agcaccctgc actgattccg gtgctgaggc cgtaccagag agaggcagtc aactggatgc
     1081 tacagcagga gcagttcagg agcactcctg ctggtgataa ctccctgcac ttcttgtggc
     1141 gagaaattgt tacacctgat ggcttgaacc tctactataa tccgtacaca ggctgcatca
     1201 ttcgggactt cccacatgct gggccacagt tgctcggtgg aatcttagca gatgagatgg
     1261 gcctcgggaa gacagtggag gttctggctc tgattctgac tcatacccga caagatgtca
     1321 gacaggatgc cctcaccctg cctgagggaa aagtggtaaa ttatttcatc ccaactcatt
     1381 gtcctagagg aaaagtgaaa agtagagaaa tccagaatac agagtgtgaa ccaaaagaga
     1441 aagttcactg ccctcccaca cgtgtgatga ttctgacagc tgtgaaagaa atgaatggga
     1501 aaaaaggcgt ttctattctt tctatctata agtatgtcag ctccacattc agatacgacg
     1561 ttcagcggaa ccggagtctt ctgaagcgga tgttgaaatg tttaatcttt gaaggtcttg
     1621 tgaaacagat taaaggccgt ggtttctctg ggacttttac actgggaaag aattacaaag
     1681 aagatgtatt tgataaaacg aaaaagcagg cagtagggag tccacaaaaa attgagaaag
     1741 agttaaggaa atcagtgaac aaggatacag attctgaata catgccatca gacatttatg
     1801 atgacgataa tgacaacgac gatgacgacg acgatgatcc ttattattat tactgcaagg
     1861 caagaaaaag ccgtaagttg aagaagaagc ctgtgttact cactaaaaag gaaaagggtc
     1921 agcctgtcaa tctggattcc caagttgagg ctccagctgc tggtgactgt gcaagcgccg
     1981 atgctcatgt gtcagaaagt acatgtgtct ctgaaaacag gcagatccaa gacgcagagg
     2041 actgtgttga gtctccaagc ccggccgcca tggagctggc acagtctaac actgcaagtt
     2101 tctgtgagac ccctgactac cgctttgagt gtatatgtgg tgaatttgac cagatcggcc
     2161 gcaagccaag agttcagtgt ctgaagtgtc acctgtggca gcatgcaaag tgtgtgaatt
     2221 acgaggagaa gaatctgaag gttaagcctt tttactgccc tcattgcctg gttgcaatgg
     2281 agccagtgtc aaccagagcg actctcatca tctccccaag ctccatttgc caccagtggg
     2341 tagatgaaat caaccggcac gtgagatcgt catcccttcg agttttggta tatcaaggag
     2401 tgaagaaaga tgggttctta cagcctcatt ttttggcaga acaagatata gttatcatta
     2461 cctatgatgt tctccgttca gaattaaact atgtcgatat cccacatagc aatagtgaag
     2521 atgggcgtcg cctgaggaac cagaagcgct acatggccat tcccagcccc ctggtagcgg
     2581 tggagtggtg gcggatctgt ctggatgaag cgcagatggt cgagtgtcct acagtaaaag
     2641 ctgcagaaat ggcccagcgt ttgagtggca ttaatcggtg gtgtgtcagt ggcactccag
     2701 tgcagagagg attggaagat ctttttgggc tggtggtctt tcttgggatt gaaccttatt
     2761 gtgtcaaaca ctggtggatt cgacttctct atcatccata ctgcaagaaa aatcctcaac
     2821 acctgtacag ttttattgct aagataatgt ggaggtccgc aaagaaagat gtcattgacc
     2881 aaatccagat cccacctcag actgaagaaa tgcactggct ccatttttcc cctgtggaga
     2941 ggcatttcta ccaccgccag catgaggtgt gctgccagga tgctgtggta aagctcagga
     3001 agatctcgga ctgggccctg aagctgagca gcttggacag aaggacggtc tcctccatcc
     3061 tgtaccccct gctgagactc aggcaggcct gctgccaccc acaggctgtg cgtggggagt
     3121 tcctgccact ccagaagagc accatgacga tggaggagtt gctgacatct ttgcagaaga
     3181 agtgtggaac agagtgtgaa gaggcccacc ggcagctagt ttgtgccctt aacggcttag
     3241 caggcatcca catcattaaa ggtgaatacg ccttggcagc ggaactctac agagaagttt
     3301 taaggtcgtc tgaggagcac aaaggaaaac tcaaaactga ttcacttcaa agacttcacg
     3361 ccacacataa cctgatggag ctcctggtag ccaaacaccc agggataccg cccaccctga
     3421 gagatggcag acttgaagaa gaggccaagc agctccgaga gcactacatg agcaagtgta
     3481 acacagaggt ggccgaagcc cagcaagctt tgcagcctgt gcagcagtcc attcgggagc
     3541 tccaaaggaa ggttcattct ggttctcctt ggtggctgaa tgtagttcac agagcaatgg
     3601 agtatgctgt tgacgaggag cttgttcagc gcgtgcgaaa tgagataagc agtaactaca
     3661 agcaccaaac ggacaaactc tccatgtcag agaagttccg tgactgtaga ggtcttcagt
     3721 tcttacttac aacacaaatg gaagagctgc acaagttcca gaagctagtg agggaggctg
     3781 tgaagaagct ggagaaacct ccgtcccggg atgtgattga gtctgcaaca gtttgccacc
     3841 tgcggccagc tagactccct ctcaactgct gtgtcttttg taaagctgat gaattgttca
     3901 cagagtatga gtcaaagcta ttttctaaca ctgtcaaagg ccagaccgcc atctttgaag
     3961 aaatgataga agatgaagaa ggactcgtgg atgatagagt ccctaccact accagaggcc
     4021 tgtgggccgt gagcgagacg gagcgatcta tgaaagcaat actatcattt gcaagatcac
     4081 ataggtttga cgttgaatat atagatgaag gaagtgtttc aatggatctc ttcgaggcat
     4141 ggaagaagga gtataagtta cttcatgaat actggatgac tctgagaaac cgcgtatccg
     4201 ctgttgatga acttgcaatg gctacagagc gactaagagt gcgccatccc aaggagccaa
     4261 agccaaaccc acccgtccac cacatcattg aaccacacga ggttgaacag aatcgtataa
     4321 aactagtaaa tgataaagct gttgctactt cccagcttca gaagaaactt ggacagcttc
     4381 tttacctgac aaatttggag aagtctcagg acaaaacatc aggaggtatt aatccagagc
     4441 cttgtccgat ctgtgctcgg cagttgggaa aacagtgggc agtgctgacc tgcggacact
     4501 gcttctgtaa tgaatgcact tcaattataa ttgaacaata cagtgtggga tcccatcgaa
     4561 gctccattaa gtgtgctatc tgccgccaga ccacatcaca caaagaagtc tcctatgtct
     4621 tcacttcaga gaaggcaaac caagaggatg atatccctgt gaagggtagc cattctacaa
     4681 aagtggaagc tgtggtcaga actctgatga aaatacaact taaagatccg ggggccaaag
     4741 cgctcgtttt ctcaacgtgg caagatgtgt tagatattat ttcaaaagct ctcacggaca
     4801 acaacatggg attcacacaa atcagtcgca ttaagacatt ccaggagaac ctttcagcat
     4861 ttaaatatga tccccagatc aatattttgc tgctgcccct gcatacaggc tctaatggat
     4921 taactatcat tgaagccact catgtcctcc tggtggaacc gatactgaat cctgcccatg
     4981 agcttcaggc cattgggaga gtgcaccgaa ttggacagac aaaacctact attgtacata
     5041 gattcttaat taaagcaaca atagaagagc ggatgcaggc aatgctaaag actgctgaga
     5101 ggagccacac cagctcgtct gggaagcatt ctgaagcctc tgcactgacc gtggctgacc
     5161 tggcagacct gttcaccaaa gagagtgagg agcttgaatg aagcgccatc gcgtcattgc
     5221 acggatgttc agacttagct ctcacagatg taaagcaagc ttacaaagtt aagatcagta
     5281 accattagta gatactattt taatgaattg attttgttat acaccagcct agtaataatt
     5341 ggcaattggt tccttttcag taaacctatt tcacaccatt tacaatgaat tttaatttta
     5401 cattcctact gaaacattta ctttttgttc tacatgtata tctataactg ataaggcagg
     5461 agaatttaaa aaagaaggta ttaaataatt tttcattagt agatagatgt ttgttataac
     5521 aagacagaat acataagaaa gaaggtaaat tagtctagtt ttgtatgacc tgacctacac
     5581 agccagtgta aatgacattt ttgaaagggc ctttggcatc tttagcttat gattcatcat
     5641 tctcttctcg gtagtgtttt aagaagacgc taaactatga tacctagttg tttgcatgag
     5701 tttaaactgt aacactctct ttggaacttt aagtagtaca gctcctgatc ataaattctt
     5761 aggtggttat tttgtgtctt gttactagcc gtcaaaatac tgaaaagctc atttttctat
     5821 tatgtttaag ccgtgtcatt gttagtgttt ttaagtgtat taacatttac ctacaatgat
     5881 ctctttaatc tttgtagtga gttctttttg tgttttaaga tgatgtatct gtaaataggg
     5941 cttttttaaa atcatcattg tactgaattc tttccctgtg ttcctgtaac taatcatttt
     6001 agccggtaat tatctaagtt tacagtagag tttattcatt tcagttactc tgtcattaag
     6061 tattttatct tactgcaaga gaatgctgtg ttcacacatg catagaacta taagtggtta
     6121 aactgtctct tctgtgaaga cttcatagat gactttgaaa tcacaaaata agaagtagct
     6181 tgtatcctaa ccctgtgttg aaatataaat gttcttgttt tccttccttt agctgttgaa
     6241 gttttaagtg actctcgaga ttcattagct cctacctaac tgcccaggaa gctgtactag
     6301 aaatagtccc tggagctcct tcatccattg agcttggtgc ttaagctaag gtgcattttc
     6361 ctatccgggt ttataggtga cagctcagct gaggaagaca cattctgggt gcttattcct
     6421 tagtgaaggg agatatgcat tggttctttt atatgagatt aaacataata tttttacagc
     6481 tctttgacat ccatgaagag cttttctgtg tattaatgta gttaattttc ccaaccgtcc
     6541 tgtgaagtgg acataattaa agtcattcct gttgtgaagg taaggagcga atgctcagga
     6601 ggaatcttgg ctatgatatg tagcaaatag acagaggagt ccaggccctg gcttcatgtc
     6661 tgcttttctt ccaccaaatc gtgtcatgct gaggtccaga agcctcagag gtgtaattta
     6721 ggggtgcgat tgttgaggtt tttctttttc ctaatatttc atgtgctatg ttctaggaaa
     6781 agcaatctga tatgcttcaa ttaaaaaaat aacataaata gatatctgta cttattagta
     6841 ttagaaaaac tactcttatt tatttcagta agatacctca aataaatatt ttagtgaaaa
     6901 atgaaa
//
LOCUS       NM_012519               4193 bp    mRNA    linear   ROD 13-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            delta (Camk2d), transcript variant 1, mRNA.
ACCESSION   NM_012519
VERSION     NM_012519.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Arias-Chavez,D.J., Mailloux-Salinas,P., Altamirano,J., Huang,F.,
            Gomez-Viquez,N.L. and Bravo,G.
  TITLE     Consumption of combined fructose and sucrose diet exacerbates
            oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts
            from rats with metabolic syndrome
  JOURNAL   Mol Cell Biochem 477 (4), 1309-1320 (2022)
   PUBMED   35138512
  REMARK    GeneRIF: Consumption of combined fructose and sucrose diet
            exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation
            in hearts from rats with metabolic syndrome.
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   3  (bases 1 to 4193)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4193)
  AUTHORS   Zhang,M., Yang,X., Zimmerman,R.J., Wang,Q., Ross,M.A.,
            Granger,J.M., Luczak,E.D., Bedja,D., Jiang,H. and Feng,N.
  TITLE     CaMKII exacerbates heart failure progression by activating class I
            HDACs
  JOURNAL   J Mol Cell Cardiol 149, 73-81 (2020)
   PUBMED   32971072
  REMARK    GeneRIF: CaMKII exacerbates heart failure progression by activating
            class I HDACs.
REFERENCE   5  (bases 1 to 4193)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   6  (bases 1 to 4193)
  AUTHORS   Deng,A.Y., Dene,H. and Rapp,J.P.
  TITLE     Mapping of a quantitative trait locus for blood pressure on rat
            chromosome 2
  JOURNAL   J Clin Invest 94 (1), 431-436 (1994)
   PUBMED   8040284
REFERENCE   7  (bases 1 to 4193)
  AUTHORS   Edman,C.F. and Schulman,H.
  TITLE     Identification and characterization of delta B-CaM kinase and delta
            C-CaM kinase from rat heart, two new multifunctional
            Ca2+/calmodulin-dependent protein kinase isoforms
  JOURNAL   Biochim Biophys Acta 1221 (1), 89-101 (1994)
   PUBMED   8130281
REFERENCE   8  (bases 1 to 4193)
  AUTHORS   Mayer,P., Mohlig,M., Schatz,H. and Pfeiffer,A.
  TITLE     New isoforms of multifunctional calcium/calmodulin-dependent
            protein kinase II
  JOURNAL   FEBS Lett 333 (3), 315-318 (1993)
   PUBMED   8224201
REFERENCE   9  (bases 1 to 4193)
  AUTHORS   Schworer,C.M., Rothblum,L.I., Thekkumkara,T.J. and Singer,H.A.
  TITLE     Identification of novel isoforms of the delta subunit of
            Ca2+/calmodulin-dependent protein kinase II. Differential
            expression in rat brain and aorta
  JOURNAL   J Biol Chem 268 (19), 14443-14449 (1993)
   PUBMED   8390994
REFERENCE   10 (bases 1 to 4193)
  AUTHORS   Tobimatsu,T. and Fujisawa,H.
  TITLE     Tissue-specific expression of four types of rat
            calmodulin-dependent protein kinase II mRNAs
  JOURNAL   J Biol Chem 264 (30), 17907-17912 (1989)
   PUBMED   2553697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 10, 2025 this sequence version replaced NM_012519.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1621941.1,
                                           SRR26360176.555331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000002.1  217698357-217698837
            482-576             JAXUCZ010000002.1  217700418-217700512
            577-636             JAXUCZ010000002.1  217784932-217784991
            637-691             JAXUCZ010000002.1  217831651-217831705
            692-757             JAXUCZ010000002.1  217873446-217873511
            758-830             JAXUCZ010000002.1  217876732-217876804
            831-933             JAXUCZ010000002.1  217886530-217886632
            934-1017            JAXUCZ010000002.1  217889972-217890055
            1018-1112           JAXUCZ010000002.1  217901439-217901533
            1113-1235           JAXUCZ010000002.1  217902908-217903030
            1236-1319           JAXUCZ010000002.1  217903809-217903892
            1320-1362           JAXUCZ010000002.1  217904780-217904822
            1363-1400           JAXUCZ010000002.1  217908116-217908153
            1401-1460           JAXUCZ010000002.1  217912214-217912273
            1461-1502           JAXUCZ010000002.1  217914468-217914509
            1503-1551           JAXUCZ010000002.1  217916935-217916983
            1552-1627           JAXUCZ010000002.1  217946550-217946625
            1628-1722           JAXUCZ010000002.1  217955065-217955159
            1723-1951           JAXUCZ010000002.1  217957098-217957326
            1952-2040           JAXUCZ010000002.1  217958485-217958573
            2041-4193           JAXUCZ010000002.1  217959746-217961898
FEATURES             Location/Qualifiers
     source          1..4193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4193
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="calcium/calmodulin-dependent protein kinase II
                     delta"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
     exon            1..481
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    342..344
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="upstream in-frame stop codon"
     CDS             417..2018
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent protein kinase type II delta
                     chain; calcium/calmodulin-dependent protein kinase type II
                     subunit delta; caMK-II subunit delta; caM-kinase II delta
                     chain; caM kinase II subunit delta;
                     Ca++/calmodulin-dependent protein kinase II, delta
                     subunit; calcium/calmodulin-dependent protein kinase (CaM
                     kinase) II delta; Ca++/calmodulin-dependent protein kinase
                     2 delta subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit delta isoform 1"
                     /protein_id="NP_036651.1"
                     /db_xref="GeneID:24246"
                     /db_xref="RGD:2263"
                     /translation="MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI
                     INTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI
                     VAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGL
                     AIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED
                     QHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRS
                     TVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKAN
                     VVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLI
                     EAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILN
                     PHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPT
                     VPIKPPCIPNGKENFSGGTSLWQNI"
     misc_feature    420..422
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    450..1325
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..488,498..500,537..539,543..545,636..638,
                     684..695,705..707,711..713,819..824,828..830,834..839,
                     843..845,882..887,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(474..485,498..500,537..539,543..545,636..638,
                     684..695,705..707,834..839,843..845,882..887)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(486..488,705..707,711..713,819..824,828..830,
                     834..836,894..896,939..953,957..959)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(882..914,921..953)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    1263..1292
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Autoinhibitory domain. /evidence=ECO:0000250"
     misc_feature    1275..1277
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1287..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Calmodulin-binding. /evidence=ECO:0000250"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1296..1298,1302..1325)
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1332..1334
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1335..1337
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1359..1361
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1368..1370
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); acetylation site"
     misc_feature    1371..1373
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1425..1541
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="propagated from UniProtKB/Swiss-Prot (P15791.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1506..1508
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1509..1511
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1515..1517
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1524..1526
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1527..1529
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1554..1937
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1986..1988
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13557; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     misc_feature    1998..2000
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PHZ2; propagated from
                     UniProtKB/Swiss-Prot (P15791.1); phosphorylation site"
     exon            482..576
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..636
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            637..691
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..830
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1017
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1112
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1362
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1400
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1460
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1502
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1551
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1627
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1722
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1951
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2040
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..4193
                     /gene="Camk2d"
                     /gene_synonym="CAMK1; Camk2; Camki; RATCAMKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcccgca ggttcccagc cttgcggccc cgtggggaga gagcgcaggc caccagcgcc
       61 gcctccgccc gcaggagcga ccccttgggt gttcactctt ggccactgcc gcccgccacc
      121 ccgggcgcta cgttgagctc tccgtgcggc ctcggtgacc gcggcagccc ctcctgacac
      181 ctcccccccg ccccttcggg agcgctcgcc cggcgggagg aggaggaaga aggatcgcgg
      241 ctcgggctgg tctggccacc tcgccccgcg cgccccgccc ctgcgcgcac tccctcgccg
      301 gcgagctact ttcggacaag gaaagtgagg gcggccccgg gtgacagcgc ggcggtgcca
      361 gtcccgggaa gccgcgtctg ttcgcgtgtc gcccgtcgca ctgtccagac cccgccatgg
      421 cttcgaccac cacctgcacc cggttcaccg acgagtatca gctcttcgag gagctcggaa
      481 agggggcatt ctcagtggtg agaagatgca tgaaaatccc tactggacaa gagtatgctg
      541 ccaaaattat caacaccaaa aagctttctg ctagggatca tcagaaactg gaaagggaag
      601 ctagaatctg ccgtctcttg aagcacccca atattgtgag acttcatgac agcatatccg
      661 aagagggctt ccattacttg gtgtttgact tagttactgg tggcgaactc tttgaagaca
      721 tagtggcaag agaatattac agtgaggctg atgccagtca ttgtatacaa cagattctag
      781 agagtgtaaa tcattgtcac ctaaatggca tagttcacag ggacctgaag cctgagaatt
      841 tgcttttagc tagcaaatcc aaaggagcag ctgtgaaact ggcagacttc ggcttagcca
      901 tagaagttca aggcgaccag caggcgtggt ttggttttgc tggcacacct gggtatcttt
      961 ctccagaagt cctacgtaaa gatccttatg gaaaaccagt ggacatgtgg gcatgtggcg
     1021 tcatcctcta catcttgctg gtgggatacc cacccttctg ggatgaagat cagcatagac
     1081 tgtatcagca gatcaaggct ggagcatacg attttccatc accagaatgg gacacagtga
     1141 cacctgaagc caaagacctc atcaacaaaa tgctgaccat caaccctgcc aaacgcatca
     1201 cagcctctga ggccctgaaa cacccatgga tctgtcaacg ttctactgtt gcctccatga
     1261 tgcacaggca ggagactgta gactgcttga agaaatttaa tgctcgacgg aaattgaagg
     1321 gtgccatctt gacaactatg ctggctacga gaaatttttc agcagccaag agtttgttga
     1381 agaaaccgga tggggtaaag ataaacaaca aagccaacgt ggtaaccagc cccaaagaaa
     1441 atattcctac cccggcgctg gagccccaaa ctactgtaat ccacaaccct gatggaaaca
     1501 aggagtcaac tgagagctca aataccacca ttgaggatga agacgtgaaa gcacgaaagc
     1561 aagagatcat caaagtcact gagcagctga ttgaagctat caacaatggg gacttcgagg
     1621 cttacacgaa aatctgtgat ccaggcctca ctgcctttga acccgaagca ttgggcaact
     1681 tagtggaagg gatggacttt cacagattct actttgaaaa tgctttgccc aaaatcaata
     1741 aaccaatcca cactatcatc ctgaaccctc acgtacacct ggtaggggat gatgcagcct
     1801 gcatagcata cattcggctc acacagtaca tggatggaaa tggaatgcca aagacaatgc
     1861 agtcagaaga gactcgagtg tggcaccgcc gtgatgggaa gtggcagaat attcactttc
     1921 atcgttcggg gtccccaaca gtccccatca agccaccctg tattccaaat gggaaagaaa
     1981 acttctcagg aggcacctct ttgtggcaaa acatctgaaa accattcaca tttgggtctt
     2041 ctaattgtca acagtgccac gtcttcattc tgtcctcaag gcacctggcg gggtgatcct
     2101 gggacatcct ctcctcttca tgcatgtttc tgagtgcatg aagttgtgaa ggttctacgt
     2161 gtaatgcata tgtgacacgt catcttacca tgtgacacgc catcttacca tgtattcctt
     2221 cctgtacatt gtttacactc cagctactgg acggatgttc catgcaaacg tcagttactg
     2281 ctggcaaact aaagagggag ctccgacaag aaaactccgc aatactccaa gttcagctga
     2341 tccatcaggt ttctctgtgg atgccaagat tcaaaagact tcataaaatt actgttcaat
     2401 gaatgacagt gtgtaagagg aaaggaaatc tttcaagaat gctgccatta atctatttgg
     2461 gcttctcatt gggattttgg ggttgatttt tttttcattt tttaaggcaa atatatatat
     2521 atatatatat atatatatat atatatatat atatatatat atgccttcag ttcctggtag
     2581 aaatgaatgg atgccttttc tctgaaagtg ttggtgttgg ataaatggat ggctatgtga
     2641 gccaagtcct gggtgattgt aggagcaaga atcgtttgct gttctaccat caaagccatg
     2701 ttgatttggg tcgagctctg tatactggaa aaattcacat cattttctag tttgattgct
     2761 ttcagatagg cacagttctg gtgaatgctt ggcactgatc ttggtttttc tttcctaaat
     2821 ctgtgttctg ttttcattat atactatttg ctcctttcct ttgtatttgt tttcttttcc
     2881 cactcttttc tttatctttc tctctcccac tttctttctt ttttatgttt tcctttctat
     2941 agctgatagt gtgtaaaaac agtaacattt gcatatgaag ttaaaataaa aatcaaggtc
     3001 ttctagaagc taaaactagc acttccggtc tctcacgggg ctgtggagtt gttagaagat
     3061 ttaaataaat acttaaataa gagaggaatg aattcagctt aggttaccac ttgtgcatag
     3121 gtatccttgc tctgttgaaa gtgttggaat tgttgagact taagctaaca gcagtaagag
     3181 cctgcttaca cagtcctggt tctccccaac tagatattga agaccaagtg gagcctgacc
     3241 agggttgcat gcagagcact tgttttggac cttccagact aggaggcatt tactgcctca
     3301 ctttcactag ctagccacag gaagagtgtt ctccatcctc ctagaggttg aacttgacct
     3361 tcgtgactag tgcagttcta gcttctctct tgagtcacag tagcatcctg atgccaggag
     3421 ttaggctttt gtccagatta aaacaacgag gaaaaggaaa tgccccagtt ttctttccgt
     3481 ttcccatttc ttctttgtcg attcggtccc tgggagactg tttctccgcg ctgaactgct
     3541 ttatggtgca tggaatctcc atcagcgtac ttctacccta gccactcaca ctccttagaa
     3601 gctgattttt aaagcagaag caaggaagca aaagtaaaac actcccttcc cctctttttc
     3661 ctcatttcac cttttggtgt tgattgctaa tcactttaga tatattgttg ctagtgaatg
     3721 tatgatagat gggttgaagc ttttctgata attagcacat gatttaaaac aatatatatt
     3781 taaaacaaat atatacagta catgtattga gccgtgttaa cctgccaatg agatctgtga
     3841 aaaacgtaat ggcctcactt ttccctttga atttctttta cctttctgtg aagcagctct
     3901 gcgtggcata catgtattta aaaacacaaa tagtggtaga atgggttttt tttttacact
     3961 tttaacttag catgtggtgt tgaagtatta ccatagatcc agtttgtctt ctgcactaag
     4021 atgtgaggaa atcgtgattt gttctctcca gcacagtgga attacacctt catcatcttc
     4081 tattgttttg aaaacactgc agtttaccat gggacactgt atataattct tgccgtaatg
     4141 gtaaatgaca aattgatata tttaagagtt aataaatttg tgatttctgc tga
//
LOCUS       NM_001108564            7567 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus amylo-alpha-1,6-glucosidase and
            4-alpha-glucanotransferase (Agl), transcript variant 1, mRNA.
ACCESSION   NM_001108564 XM_001073642 XM_342331
VERSION     NM_001108564.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7567)
  AUTHORS   Cheng,A., Zhang,M., Gentry,M.S., Worby,C.A., Dixon,J.E. and
            Saltiel,A.R.
  TITLE     A role for AGL ubiquitination in the glycogen storage disorders of
            Lafora and Cori's disease
  JOURNAL   Genes Dev 21 (19), 2399-2409 (2007)
   PUBMED   17908927
REFERENCE   2  (bases 1 to 7567)
  AUTHORS   Lucchiari,S., Pagliarani,S., Salani,S., Filocamo,M., Di Rocco,M.,
            Melis,D., Rodolico,C., Musumeci,O., Toscano,A., Bresolin,N. and
            Comi,G.P.
  TITLE     Hepatic and neuromuscular forms of glycogenosis type III: nine
            mutations in AGL
  JOURNAL   Hum Mutat 27 (6), 600-601 (2006)
   PUBMED   16705713
REFERENCE   3  (bases 1 to 7567)
  AUTHORS   Lees,S.J., Chen,Y.T. and Williams,J.H.
  TITLE     Glycogen debranching enzyme is associated with rat skeletal muscle
            sarcoplasmic reticulum
  JOURNAL   Acta Physiol Scand 181 (2), 239-245 (2004)
   PUBMED   15180797
REFERENCE   4  (bases 1 to 7567)
  AUTHORS   Becker,K.G., Barnes,K.C., Bright,T.J. and Wang,S.A.
  TITLE     The genetic association database
  JOURNAL   Nat Genet 36 (5), 431-432 (2004)
   PUBMED   15118671
REFERENCE   5  (bases 1 to 7567)
  AUTHORS   Schliselfeld,L.H. and Danon,M.J.
  TITLE     Inverse relationship of skeletal muscle glycogen from wild-type and
            genetically modified mice to their phosphorylase a activity
  JOURNAL   Biochem Biophys Res Commun 290 (2), 874-877 (2002)
   PUBMED   11785984
REFERENCE   6  (bases 1 to 7567)
  AUTHORS   Popova,I.A., Presnova,V.N. and Lavrenova,T.P.
  TITLE     [Effect of biogenic amines on glycogen degradation in isolated rat
            hepatocytes]
  JOURNAL   Vopr Med Khim 38 (2), 30-33 (1992)
   PUBMED   1413626
REFERENCE   7  (bases 1 to 7567)
  AUTHORS   Chen,Y.T., He,J.K., Ding,J.H. and Brown,B.I.
  TITLE     Glycogen debranching enzyme: purification, antibody
            characterization, and immunoblot analyses of type III glycogen
            storage disease
  JOURNAL   Am J Hum Genet 41 (6), 1002-1015 (1987)
   PUBMED   2961257
REFERENCE   8  (bases 1 to 7567)
  AUTHORS   Satoh,K. and Sato,K.
  TITLE     Glycogen-binding protein components of rat tissues
  JOURNAL   Biochem Biophys Res Commun 96 (1), 28-33 (1980)
   PUBMED   6449198
REFERENCE   9  (bases 1 to 7567)
  AUTHORS   Vaillant,R., Bourgeois-Victor,P. and Fairand,A.
  TITLE     [Development and control of liver amylo-1,6-glucosidase activity in
            the fetal rat]
  JOURNAL   Can J Biochem 57 (10), 1245-1249 (1979)
   PUBMED   120213
REFERENCE   10 (bases 1 to 7567)
  AUTHORS   Mannan,A., Noujaim,A.A., Wiebe,L.I., Secord,D.C. and
            Silverberg,D.S.
  TITLE     Carbohydrate metabolism in the chronically uremic rat
  JOURNAL   Clin Biochem 8 (3), 194-198 (1975)
   PUBMED   807434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342331.3, XM_001073642.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..7567
                     /gene="Agl"
                     /note="amylo-alpha-1,6-glucosidase and
                     4-alpha-glucanotransferase"
                     /db_xref="GeneID:362029"
                     /db_xref="RGD:1306376"
     exon            1..475
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            476..625
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    505..507
                     /gene="Agl"
                     /note="upstream in-frame stop codon"
     CDS             544..5142
                     /gene="Agl"
                     /note="amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
                     (glycogen debranching enzyme, glycogen storage disease
                     type III); amylo-1,6-glucosidase,
                     4-alpha-glucanotransferase; amylo-alpha-1, 6-glucosidase,
                     4-alpha-glucanotransferase"
                     /codon_start=1
                     /product="glycogen debranching enzyme"
                     /protein_id="NP_001102034.1"
                     /db_xref="GeneID:362029"
                     /db_xref="RGD:1306376"
                     /translation="MEHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKAV
                     TVYTNYPFPGEAFNREKFRSLDWENPTEREDDSDKYCKVHLQQSGSFQYYFLQGQEKS
                     GGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHF
                     TPLQALGLSRSCYSLADQLELNPDFSRPNRRYTWDDVGQLVEKLKREWNILCITDVVY
                     NHTAANSKWIHEHPESAYNLVNSPHLKPAWVLDRALWHLSCDVADGKYREKGVPALIE
                     NDHHMNCIRKIIWEDIFPRIQLWEFFQVDVQKAVEQFRRLLSQENRRVTKSEPKEHLK
                     IIQDPEFRRLGCAVDMNIALATFIPHDNGPAAIEECCNWFRKRLEELNSEKHHLTSCH
                     QEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFTFPFEEMALSAEESLLHRPD
                     KACFLMAHNGWVMGDDPLRNFAEPGSNVYLRRELICWGDSVKLRYGNKPEDCPYLWAH
                     MKKYTEITATHFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAELFTGSEDLDNI
                     FVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDI
                     THDNECPIVHRSAYDALPSTTVVSMACCASGSTRGYDELVPHQISVVAEERFYTKWNP
                     GASPSDTGDVSIHSGIIAARCAINRLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIH
                     QSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSING
                     MPNMTVELRERIQLHESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHA
                     QVAVGILRNHLTQFSSHFKSGSLAVDNSDPILKIPFASIASKLTLAELNQVLYRCESE
                     EQEDGGGCYDIPNWSSLKYAGLQGLMSVLAEIRPKNDLGHPFCENLRSGDWMIDYVSG
                     RLISRSGSIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDVAWKQMSSFV
                     QNGSTFVKHLSLGSVQMCGVGKCPCLPLLSPSLLDVPCRLNEITKEKEQCCASLAAGL
                     PHFSSGLFRCWGRDTFIALRGMLLVTGRYLEARNIILAFACTLRHGLIPNLLGEGTYA
                     RYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVI
                     QEAMQRHMQGIQFRERNAGPQIDRNMKDEGFNITVGVDEETGFVYGGNRFNCGTWMDK
                     MGESDRARNRGIPATPRDGSAVEIVGLCKSAVRWLLELSKKNIFPYHEVRVRRHGKVV
                     AVSYDEWNRKIQNSFEKLFHVSEDPSDPNEKHPNLVHKRGIYKDSYGASSPWCDYQLR
                     PNFTIAMVVAPELFTAEKAWKALEIAEGKLLGPLGMKTLDPDDMVYCGVYDNALDNDN
                     YNLARGFNYHQGPEWLWPIGYFLRAKLYFSKMMGPETAAKTVFLVKNVLSRHYVHLER
                     SPWKGLPELTNENGQYCPFSCETQAWSMAAVLETLYDL"
     misc_feature    607..5139
                     /gene="Agl"
                     /note="glycogen debranching enzymye; Region:
                     glyc_debranch; TIGR01531"
                     /db_xref="CDD:273673"
     misc_feature    607..5139
                     /gene="Agl"
                     /note="glycogen debranching enzymye; Region:
                     glyc_debranch; TIGR01531"
                     /db_xref="CDD:273673"
     exon            626..836
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1003
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1207
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1389
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1501
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1625
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1728
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1826
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1966
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2154
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2278
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2442
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2544
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2700
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2851
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2976
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3089
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3224
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3355
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3492
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3626
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3802
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3905
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4131
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4243
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4379
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4492
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4493..4704
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4802
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4803..4890
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..5024
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..7567
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtaagtgtc tggaatgcgt ccggctctgg acgcgcattc tttctatcta tagcagctct
       61 gtacatcgca agccgccgca gctattcccg gggcagcaac tgcttccctc tcgaatcacc
      121 tccctattgg tggcttcaga cccgaatttg ggaacggggc gctcttccac ctgttcagca
      181 gcctgatctc ctggaggctg cagtgccatt tggagcttac agggccctct ggctcaggga
      241 cggaatttat gccactgatc tccagggttt tcgcggatgc attgcttttc tctgagaatg
      301 ttttaagggg ttttttggtc tgttctgttt tgatcagagt gtaagactct acgtctttgc
      361 ttcaggcttt cttattctgc tccaagagag aagaaacttc ttgcttgtcg gactttactg
      421 acaagatttc attctttctc tttgctcttc ttggctttaa ccatatctag gacatgggta
      481 actcattcca cttcggagtt cttttaattc tacggaaaga gttcagatcc cccagaggcc
      541 aaaatggaac acagtaagca gattcgaatt ttactattga acgaaatgga gaagctagag
      601 aagaccctct tcagacttga gcaaggattt gaactacagt tccgattagg cccaacttta
      661 caaggaaaag ctgttactgt ttatacaaat tacccatttc ctggagaagc atttaatcga
      721 gaaaaattcc gttccttgga ttgggaaaac ccaacagaga gagaagatga ttcggacaaa
      781 tactgtaaag ttcatctgca gcagtctggg tcttttcagt actacttcct tcaaggacag
      841 gagaaaagtg gcggaggtta catagttgtg gatcctattc tgcgagttgg agctgataat
      901 cacgtgctac ccttggattg tgttactctg cagacatttt tagcaaagtg tttaggaccc
      961 tttgatgagt gggaaagccg actacgggtg gcaaaggagt caggctacaa catgattcac
     1021 ttcaccccgc tgcaggctct cggactgtcc aggtcatgct attcccttgc cgatcagtta
     1081 gaattaaatc ctgacttctc aaggcccaat agaagataca cctgggatga tgttgggcag
     1141 ctagtagaga agctgaagag ggagtggaac attctttgta ttaccgatgt ggtctacaat
     1201 catactgctg ctaatagtaa gtggatccat gagcatccag aatctgcgta caatcttgta
     1261 aattctccac acttgaaacc tgcctgggtc ctagacagag cgctctggca tttgtcctgt
     1321 gatgttgcag atgggaagta cagagaaaaa ggagtccctg ctctaattga aaatgaccat
     1381 cacatgaact gcattcggaa aataatttgg gaggacattt tcccaaggat tcagctctgg
     1441 gagtttttcc aagtagatgt tcagaaagcg gttgaacaat ttagaagact gctctctcaa
     1501 gaaaacagaa gagtaactaa gtctgaaccg aaagaacatc ttaaaattat tcaggacccc
     1561 gaattcaggc ggctgggctg tgctgtagat atgaacattg ctctggcgac ctttatacca
     1621 catgacaatg ggccagctgc aattgaagag tgctgtaatt ggttccgtaa gagactcgag
     1681 gagttaaatt cagagaaaca ccacctcacc agctgtcatc aggaacaggc cgttaattgt
     1741 cttttgggaa acgtgtttta tgaacggctg gcgggccatg gccctaaact aggacccgtc
     1801 accaggaagt accctttagt taccaggtat tttactttcc cctttgaaga aatggccttg
     1861 tctgcagaag agtccctgct ccaccgccca gataaagctt gctttctgat ggcacacaat
     1921 ggctgggtga tgggcgatga cccgcttcgg aactttgctg agccaggttc caacgtttat
     1981 ttaaggagag aacttatttg ctggggtgac agtgtgaaat tgcgctatgg gaacaaaccg
     2041 gaggactgcc cttacctgtg ggcacacatg aagaaataca ctgagatcac tgccactcac
     2101 ttccagggag tgcgccttga caactgccac tccacgcctc tccacgtggc tgagtacatg
     2161 ctggatgctg ctaggaaatt acagcccaat ctttatgtag tggctgagct gttcacagga
     2221 agcgaagatc tggacaatat cttcgttact agactgggca tcagttcctt aataagagag
     2281 gcaatgagcg catataacag tcacgaagag ggcagattgg tctaccggta cggaggggag
     2341 cccgtcggat ccttcgttca gccctgtttg aggcctctta tgccagctat cgcgcatgcc
     2401 ctgtttatgg acatcaccca cgataatgag tgtccaattg tgcacagatc agcctatgat
     2461 gcgcttccaa gtaccacagt tgtctccatg gcgtgttgtg ctagtggaag tacaagaggc
     2521 tacgacgagc tagtgcctca tcagatttca gtggttgctg aagaacggtt ttacactaag
     2581 tggaatcctg gggcatcccc atcggataca ggagatgtta gcatccacag tgggattatt
     2641 gcagccagat gtgccatcaa cagactccat caagagcttg gagccaaggg tttcattcaa
     2701 gtgtatgtgg atcaagtgga tgaagacata gtggcagtaa ccaggcactc accaagcatc
     2761 catcagtctg ttgtggctgt atcgagaacg gcttttagga atcccaagac ttcattttac
     2821 agcaaagaag tgcctcaaat gtgcatccct ggcaaaattg aagaggtagt tctggaagct
     2881 agaactattg agaggaatac aaaaccttat aggaaagatg agaattcaat caatggaatg
     2941 ccgaacatga cagtggaact tagagaacgt atccagcttc atgaaagtaa aattgtcaaa
     3001 caagctggag ttgccacaaa gggtcccaat gaatatattc aggaaataga atttgaaaac
     3061 ctatctccag gaagtgttat tatattcaga gttagccttg atccacatgc gcaagttgct
     3121 gttggaattc ttcgaaatca cctgacccaa ttcagctccc attttaaatc tggaagcctt
     3181 gctgttgaca actcggatcc tatattaaaa atccccttcg cttccattgc ctctaaattg
     3241 actttggctg agctaaatca ggtactttac cgatgtgaat cagaagaaca agaagacggt
     3301 ggaggttgct atgatatacc aaactggtcg tcccttaagt atgcaggtct gcaaggatta
     3361 atgtccgtgc tggcagaaat aagaccaaag aatgacttgg ggcatccctt ctgtgaaaac
     3421 ttgaggtctg gagactggat gatcgactac gtcagtggcc ggctaatctc acgatcaggg
     3481 agtattgctg aagttggaaa atggttgcag gctatgttct tctacctgaa gcagatcccg
     3541 cgatatctca tcccatgtta ctttgatgct atattaatcg gtgcatatac cactctgctg
     3601 gatgtagcct ggaaacagat gtcaagcttt gttcagaatg gctcgacctt cgtgaagcac
     3661 ctgtccctgg gttctgtcca gatgtgtgga gtcgggaagt gtccttgtct gccgctgctt
     3721 tcaccctcac tcctggatgt gccgtgcagg ttaaatgaga tcacgaagga gaaagagcag
     3781 tgctgtgctt ccttggctgc aggcttacct cacttttctt ctggtctttt tcgctgctgg
     3841 gggagggata ctttcattgc acttcgaggg atgctgctgg ttactggtcg ctacctagaa
     3901 gccaggaata ttattttagc atttgcttgt accctgaggc atggtctcat tcctaacctc
     3961 cttggcgaag gaacgtatgc caggtacaac tgtcgtgatg ccgtgtggtg gtggctgcag
     4021 tgcattcagg actattgcaa gatggttcca aatggtctag acatcctcaa atgcccagtt
     4081 tccagaatgt atccaacaga tgactctgca cctttgcctg ctgggactct ggatcagcct
     4141 ttgtttgaag tcatacagga agctatgcag aggcacatgc aaggcattca gttccgagag
     4201 cggaatgccg gtccacagat cgatcgaaac atgaaggatg agggtttcaa cataaccgtg
     4261 ggggttgatg aagaaacagg atttgtttat ggaggaaatc gcttcaactg tggcacatgg
     4321 atggataaaa tgggagagag tgacagagct agaaacagag ggatcccagc caccccaaga
     4381 gatgggtctg ctgtggaaat cgtgggcttg tgtaaatctg ctgttcgttg gttgctggaa
     4441 ttgtccaaga aaaacatttt tccttatcat gaagtcagag taagaagaca tggaaaggtt
     4501 gtagcagtct cctatgatga gtggaacaga aaaatacaaa acagttttga aaagctcttt
     4561 catgtttccg aagacccttc agatcctaac gagaagcatc cgaatctggt tcacaagcgg
     4621 ggcatctaca aggacagcta cggtgcgtca agtccttggt gtgactatca gctcaggccc
     4681 aactttacca tagcaatggt cgtggcccct gagctcttta ctgctgaaaa ggcttggaag
     4741 gctttggaaa ttgcagaagg aaaattgctt ggtccccttg gcatgaagac tttggatcca
     4801 gatgacatgg tttactgtgg agtctatgac aatgccttag acaatgacaa ctacaacctt
     4861 gccagaggtt tcaattacca ccaaggacct gagtggctat ggccgattgg gtattttctt
     4921 cgtgcaaagt tgtatttttc caaaatgatg ggcccagaga ctgctgcgaa gactgtattt
     4981 ttggttaaaa atgttctttc tagacattat gttcatcttg agagatcccc atggaaagga
     5041 cttccagagc tcaccaatga gaatggccag tactgccctt tcagctgtga gacacaggca
     5101 tggtcgatgg ctgctgttct cgaaaccctc tatgatctat agttggctcg tagatactta
     5161 gtaattgtgt gaacacttga cattattgaa tgcaaggtca taaggaaatg taagctcaac
     5221 tcattttaaa aatcccattc atagccaggg agtggtggtg tacaccgttg atcccagcac
     5281 tcgggaaaca gaagcaggca gatctcttga gttcgataga ggccagcctg gtctacaaag
     5341 aaagttcctg gacagccagg ggtacacaga gaaaccctgt gtcgaaaaac caaaaattaa
     5401 acaaacaaaa aaaaatagat tttttttggc tttttttctt aaagaatatc atgtgtactg
     5461 gggattacac gaaggacctc atgtatgtta gacaagcatt ctaccaactg aacttcatcc
     5521 tgtgtcctat tttttctata ttcttttgat ttgaatcgaa gaaaaatgat cttttcccat
     5581 agaaggttac agggaaaagt attcttcaaa gcagggttta aaaacagtgt attatcttca
     5641 gtttagagga agaagtcctg ctgtctgttg gcacactcca caggctgtgt catgaatgct
     5701 ctaacgtttg ctacagcagt cttaatacca tgcctaatgc agtcagtgca cacttgttaa
     5761 atgttttatg aatgtggaat tatggaagtt tccacccaca gtatatgttc atagctggag
     5821 cacagagctt caaaatgtgc tttatttttc atggacaagt tatgttttta atatagtaaa
     5881 tgccaactat acttaatata gcctatttgt gttaaagagt aattggtcgt aataaaacag
     5941 accactagaa cataagacaa ttctgtaaaa ttagttctaa tttcccacta tgagatagtt
     6001 tacattttca aaatggaaat tactgggcat atttatgaaa tttttcaagg gggaaaaaag
     6061 cttagagctg tacttggtga cacagcttgc ttagcatggt caaggccttg agttctatcc
     6121 ctaaaaccat caagaaagga aggaaggagt ataagagggg agggagggag gaaagaaaga
     6181 gggaagattt aaaatagagc catattaggt tatcaacaat agggtcacca tccacctcag
     6241 aaaatcctta gggtacagtg cttatactga ggactgttga tgaaaggctg gtgctgtgtt
     6301 gggcatggtc tatgtgaaag tctaggaggt gtattttacc ttatcccagc cacagtaatt
     6361 agactggaaa aggataatgg ccatttgact gaagaactct taggtgcaac gcttcgttcc
     6421 tgtgtgatgc tgcagaaagt ttcccaaacg gtccgtgcct tggtttgtca catatcaaac
     6481 caatcttact ctgctaagtg aaaggtaaac ttagcagttg aaccagcatg ctgtggtatt
     6541 gtagtgagtt ttcatagatg actgaggagg cagggagcct gtcatttagt acatcaccta
     6601 agtggtaatc atttccactg tgtcctaaac ggctctgagt actgagcaaa tgtgtatatg
     6661 tctgtgtgtc aaaataaaag ttttttttta aaggactctc tttgctttcc ttcgtcttct
     6721 ttactgtaaa ttttccctgt cctcatgagt ggtgctcaga gatttacctt ttataggata
     6781 taggagcagg gagaggagga agagagaagg ctgtctggag atttattaaa gtagccatgt
     6841 gtaaattagg agtgaagtaa gctttcagtg tatccctaag tctgttagca tctgtactcc
     6901 tttgatatat cttgagtaca gtgaattttt atttacattt taccaactca caaatatagt
     6961 aacaaatgga tgtgaacatt tactttctga aaaagccaga caatttttgc tttattttat
     7021 ttatttattt atttatttat ttatttattt atttattttt ggagctgggg accgaaccca
     7081 ggaccttgcg cttgctaggc aagcgctcta ccactgagct aaatccccaa ccccagattt
     7141 atttattata tatgagtaca atgtagctgt cttcagacac accagaagaa ggcttcagac
     7201 ctcattacaa atggttttga gccaccatgt ggttgctggg aattgaactc aggacctctg
     7261 gaagagcagt cagtgctctt aaccactgag ccatctctcc agctctgctt cattctttta
     7321 tactacagat tctatgtctt tacttttaga tagaaggtgc taacataaga atctataatt
     7381 ccacgttgtt cgaaatggat cagtcagact tgctgcattt acttacttaa ccctccatac
     7441 accagtaccg ggaagtcagg gaatcagggt agttagcttt tgctggtttt ttctatttct
     7501 gtccaccctg gattataaag gagtgatgac attagagctg atgcttcttt aactgggtct
     7561 catgtga
//
LOCUS       NM_001437984            2377 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus cyclin dependent kinase 2 (Cdk2), transcript
            variant 2, mRNA.
ACCESSION   NM_001437984 XM_006240778
VERSION     NM_001437984.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2377)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 2377)
  AUTHORS   Matveevsky,S., Chassovnikarova,T., Grishaeva,T., Atsaeva,M.,
            Malygin,V., Bakloushinskaya,I. and Kolomiets,O.
  TITLE     Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero-
            and Homomorphic Sex Chromosomes
  JOURNAL   Int J Mol Sci 22 (4), 1969 (2021)
   PUBMED   33671248
  REMARK    GeneRIF: Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for
            Hetero- and Homomorphic Sex Chromosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2377)
  AUTHORS   Peng,T., Peng,J.J., Miao,G.Y., Tan,Z.Q., Liu,B. and Zhou,E.
  TITLE     miR-125/CDK2 axis in cochlear progenitor cell proliferation
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300064
  REMARK    GeneRIF: miR125/CDK2 axis in cochlear progenitor cell
            proliferation.
REFERENCE   4  (bases 1 to 2377)
  AUTHORS   Ren,S., Xing,Y., Wang,C., Jiang,F., Liu,G., Li,Z., Jiang,T., Zhu,Y.
            and Piao,D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   5  (bases 1 to 2377)
  AUTHORS   Lin,Z., Liu,Z., Wang,X., Qiu,C. and Zheng,S.
  TITLE     MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal
            Tubular Epithelial Cells during Sepsis Associated Acute Kidney
            Injury via AKT/CDK2-FOXO1 Pathway
  JOURNAL   Biomed Res Int 2019, 2821731 (2019)
   PUBMED   31223614
  REMARK    GeneRIF: MiR-21-3p mediates metabolism and cell fate alterations of
            tubular epithelial cells (TECs) via manipulating AKT/CDK2-FOXO1
            pathway, and that is crucial in the regulation of energy metabolism
            of TECs during Sepsis and associated acute kidney injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2377)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   7  (bases 1 to 2377)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 2377)
  AUTHORS   Kotani,S., Endo,T., Kitagawa,M., Higashi,H. and Onaya,T.
  TITLE     A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly
            transformed rat thyroid (FRTL-Tc) cell line
  JOURNAL   Oncogene 10 (4), 663-669 (1995)
   PUBMED   7862443
REFERENCE   9  (bases 1 to 2377)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   10 (bases 1 to 2377)
  AUTHORS   Tsai,L.H., Harlow,E. and Meyerson,M.
  TITLE     Isolation of the human cdk2 gene that encodes the cyclin A- and
            adenovirus E1A-associated p33 kinase
  JOURNAL   Nature 353 (6340), 174-177 (1991)
   PUBMED   1653904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006240778.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO803815.1, FO806392.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000007.1  1721613-1721917     c
            306-383             JAXUCZ010000007.1  1720839-1720916     c
            384-504             JAXUCZ010000007.1  1720620-1720740     c
            505-675             JAXUCZ010000007.1  1719299-1719469     c
            676-777             JAXUCZ010000007.1  1717972-1718073     c
            778-921             JAXUCZ010000007.1  1716397-1716540     c
            922-1125            JAXUCZ010000007.1  1715897-1716100     c
            1126-2377           JAXUCZ010000007.1  1714392-1715643     c
FEATURES             Location/Qualifiers
     source          1..2377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2377
                     /gene="Cdk2"
                     /note="cyclin dependent kinase 2"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
     exon            1..305
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    181..183
                     /gene="Cdk2"
                     /note="upstream in-frame stop codon"
     CDS             190..1230
                     /gene="Cdk2"
                     /EC_number="2.7.11.22"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     division protein kinase 2; cyclin dependent kinase
                     2-alpha"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2 isoform 2"
                     /protein_id="NP_001424913.1"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
                     /translation="MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGV
                     PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP
                     LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYT
                     HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHS
                     LCPLCSYLEVAASQGGGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP
                     GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
                     QDVTKPVPHLRL"
     misc_feature    196..1191
                     /gene="Cdk2"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase 2 and 3; Region:
                     STKc_CDK2_3; cd07860"
                     /db_xref="CDD:270844"
     misc_feature    196..1191
                     /gene="Cdk2"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase 2 and 3; Region:
                     STKc_CDK2_3; cd07860"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,337..339,
                     379..381,427..438,445..447,451..456,568..570,574..576,
                     580..585,589..591,622..624,631..633,667..669,673..684,
                     688..690,946..951)
                     /gene="Cdk2"
                     /note="active site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,337..339,
                     379..381,427..438,445..447,451..456,568..570,574..576,
                     580..585,589..591,622..624,631..633,667..669,673..684,
                     688..690,946..951)
                     /gene="Cdk2"
                     /note="active site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,379..381,
                     427..438,445..447,454..456,580..585,589..591,622..624)
                     /gene="Cdk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    order(217..228,241..243,280..282,286..288,379..381,
                     427..438,445..447,454..456,580..585,589..591,622..624)
                     /gene="Cdk2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    order(298..300,310..321,325..327,334..339,343..348,
                     355..360,400..408,535..537,544..555,637..645,649..654,
                     658..669,1147..1149,1159..1167)
                     /gene="Cdk2"
                     /note="CDK/cyclin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270844"
     misc_feature    order(298..300,310..321,325..327,334..339,343..348,
                     355..360,400..408,535..537,544..555,637..645,649..654,
                     658..669,1147..1149,1159..1167)
                     /gene="Cdk2"
                     /note="CDK/cyclin interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:270844"
     misc_feature    order(337..339,451..453,568..570,574..576,631..633,
                     667..669,673..684,688..690,946..951)
                     /gene="Cdk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    order(337..339,451..453,568..570,574..576,631..633,
                     667..669,673..684,688..690,946..951)
                     /gene="Cdk2"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270844"
     misc_feature    619..690
                     /gene="Cdk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270844"
     misc_feature    619..690
                     /gene="Cdk2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270844"
     exon            306..383
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..504
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..675
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..777
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..921
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1125
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2377
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggaggcg gcaacattgt ttcaagttgg acaaattgtc aagagctgag ctctgcttgc
       61 gttccatccc gagctagggc tgccgtgctc acccgggccc ccaggtcctc cgctccgagt
      121 gtccggcccg ctttcgtcag ggttcccggg ccccgctccc gggggcctga gccgcctcac
      181 tagcgctcca tggagaactt ccaaaaggtg gagaagattg gagagggcac gtacggagtg
      241 gtgtacaaag ccaaaaacaa gttgacggga gaagttgtgg cgcttaagaa aatccggctc
      301 gacactgaga ctgaaggtgt gcccagtact gccatccgag agatctccct ccttaaggag
      361 ctcaatcacc ctaacatcgt caagctgctg gatgtcatcc acacagaaaa taagctttat
      421 ctggtgtttg aattcctgca ccaggacctc aagaagttta tggatgcttc tgctctcact
      481 ggcattcctc ttcccctcat caagagctat ctgttccagc tgctccaggg cctagcattc
      541 tgccattctc accgtgtcct gcaccgagac cttaagcccc agaacctgct tatcaacgca
      601 gaggggtcca tcaagctggc tgactttgga ctagcaagag cctttggagt ccctgtccgt
      661 acttacactc atgaggtggt gaccctctgg taccgagcac cggagattct tctgggctgc
      721 aagtactact ccacagccgt ggacatctgg agcctgggct gcatctttgc cgaaatgcac
      781 ctagtgtgta cccagcacca tgctaagtgc tgtggggagc acagaagaaa tggaagacac
      841 agtctctgcc cgctgtgctc ctatctagaa gtggctgcat cacaaggagg ggggatgacc
      901 gcagtgtcta ccccataccc cgtgacccgc agggccctat tccctggaga ctctgagatt
      961 gaccaactct tccggatctt tcggactctg gggaccccag atgaggtggt ttggccagga
     1021 gttacttcta tgcctgatta taagccaagt ttccccaagt gggctcggca ggattttagc
     1081 aaggttgtgc ctcccctgga tgaagacgga cggagcttgt tatctcaaat gctgcactat
     1141 gaccccaaca agcggatttc agccaaagca gccctggctc accctttctt ccaggatgtg
     1201 actaaaccag tgccccacct tcgactctga tgtccttccc aaagccctct tcacctgtgg
     1261 tctgacctga tcctgggcct tttggacaca ggtcagcctt ctgctgtttt ctggctgtct
     1321 tagccttttc tctgggccag ccggttctgg ggattcagag gtgcagagaa ggattaggtg
     1381 aaaagggaga aagttttggc attagatgca cttaacccga cttccagctt ctctccctct
     1441 tcccagtcat cactgagaag gattagtatt gaagcaaaac tgacagttct ccccagtgtc
     1501 agattttgcc atcccaacct taagactgtc tcatagttac cgtgttgagg gaaatgcccc
     1561 cagactcctg ctgacaatgt tttctaaact aatgagcaga agcctaagtt gggacagttc
     1621 agaaccaagc aagaggggtc cattttaatg aattagagta aaaaaataga cctaagccat
     1681 ttgtacctta gtcttagtgt ttggcctcat ctagcaacca aggaagcctg gttggagaaa
     1741 cagaagaaat gattccctcc agagccctgt ctcccttccc caggcaagaa gagccaggag
     1801 ggcacaggct tacgcttcac tctgatctgt gtgcttcaca gggcaaggtg aaagacactt
     1861 gaatttccct ttttagcaat cttactgttt tctggtgctg ccggctgaac ccaggacctt
     1921 gccctcacta agcaaatgta cctaccacca gtgagccaga tttcgttcga gccctccttt
     1981 gggaagttca gttcttcagt tgtcagagag ccttattacc atcttcctct gagagccacc
     2041 ctcactccta gtagtggaag cgagctagga gacatttcga gaatgctgat actttttaaa
     2101 ggctgggtta ggtcattggg ggaaattttc tataaaagag tgaacaatta tatttatatt
     2161 ttcaagttag aatagtttgg atatttcaat ggttttttgt ttgttgtttc tttttttctt
     2221 ttttgtcagt gtggatggat ttgttaccat gtgcactttg ggattttttt tttaattgtt
     2281 taaagaaaat atttctttta tgatttcctt ctcccacccc gtgttgttaa tattatttgt
     2341 aatttagttt gtaattcatt aaaagaaaat attctca
//
LOCUS       NM_001191776            2610 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus caspase 14 (Casp14), transcript variant 2, mRNA.
ACCESSION   NM_001191776 XM_063263160 XM_234878
VERSION     NM_001191776.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Gkegkes,I.D., Aroni,K., Agrogiannis,G., Patsouris,E.S. and
            Konstantinidou,A.E.
  TITLE     Expression of caspase-14 and keratin-19 in the human epidermis and
            appendages during fetal skin development
  JOURNAL   Arch Dermatol Res 305 (5), 379-387 (2013)
   PUBMED   23377137
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Alibardi,L., Tschachler,E. and Eckhart,L.
  TITLE     Distribution of caspase-14 in epidermis and hair follicles is
            evolutionarily conserved among mammals
  JOURNAL   Anat Rec A Discov Mol Cell Evol Biol 286 (2), 962-973 (2005)
   PUBMED   16142807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_063263160.1, NM_001191776.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.27728.1,
                                           SRR26643295.27356.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000007.1  11577336-11577487
            153-219             JAXUCZ010000007.1  11580311-11580377
            220-369             JAXUCZ010000007.1  11580781-11580930
            370-595             JAXUCZ010000007.1  11581031-11581256
            596-712             JAXUCZ010000007.1  11582168-11582284
            713-816             JAXUCZ010000007.1  11582443-11582546
            817-2610            JAXUCZ010000007.1  11583067-11584860
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2610
                     /gene="Casp14"
                     /note="caspase 14"
                     /db_xref="GeneID:299587"
                     /db_xref="RGD:1311781"
     exon            1..152
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Casp14"
                     /note="upstream in-frame stop codon"
     exon            153..219
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..921
                     /gene="Casp14"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="caspase-14 isoform 2"
                     /protein_id="NP_001178705.1"
                     /db_xref="GeneID:299587"
                     /db_xref="RGD:1311781"
                     /translation="MDSETINPQPLQEERYDMSGARLALTLCVTKAREGSEVDMDALE
                     RMFQYLKFESTMKRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLMAHGEEGFLKGE
                     DGNMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELPGDELAVIKKKNP
                     PTIPTYTDMIHIYSTVEGFLSYRHDQKGSGFIQTLTDVFIHKKGSITELLEEITRLMA
                     NTEVMQEGKPRKVNPEIQSTLRKKLYLQ"
     misc_feature    208..918
                     /gene="Casp14"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    208..918
                     /gene="Casp14"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    order(277..279,460..462,580..582,601..603,718..735,
                     745..750)
                     /gene="Casp14"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(277..279,460..462,580..582,601..603,718..735,
                     745..750)
                     /gene="Casp14"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(457..459,586..588)
                     /gene="Casp14"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(457..459,586..588)
                     /gene="Casp14"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(604..606,673..678,697..699,706..708,715..717,
                     787..789,811..813,829..831,868..870,883..888,892..894,
                     901..906)
                     /gene="Casp14"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(604..606,673..678,697..699,706..708,715..717,
                     787..789,811..813,829..831,868..870,883..888,892..894,
                     901..906)
                     /gene="Casp14"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(607..609,670..672)
                     /gene="Casp14"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(607..609,670..672)
                     /gene="Casp14"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     exon            220..369
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            370..595
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            596..712
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            713..816
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2610
                     /gene="Casp14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagacagga tctcagaaga aacttctgag tctgtccttt ctcagagagc aacacgtggc
       61 tctaactcct cctgagtgac agcgctgcat catccatcaa cagcttggag tcagacaagc
      121 cagggcctga cccaaggaga aggagcgcac cgggcaagac aaaggtgctg gaagccagac
      181 atggactcag agacgattaa tccccagccc ttgcaggagg agagatacga tatgtcgggt
      241 gcccgcctgg ccctgacgct gtgtgtcacc aaagcccggg agggttctga ggtagatatg
      301 gatgccctag aacgcatgtt ccagtaccta aaatttgaaa gcaccatgaa gagggatcct
      361 actgctcagc aatttctgga tgatatggat gaatttcagc agaccataga gaattggaaa
      421 gagcctgtca gctgtgcctt cgtggtactc atggcacacg gcgaggaagg cttcctcaag
      481 ggagaagacg ggaatatggt cagactggaa gacctttttg aggtcttgaa caacaagaac
      541 tgcaaggccc tgagaggcaa gccaaaagtg tatatcatcc aggcctgcag aggagagcac
      601 agagaccccg gtgaggaact acctggagat gaacttgctg tgatcaagaa gaaaaacccc
      661 ccaactatcc caacatatac ggatatgatc catatctact ccacggtaga ggggttcctc
      721 tcctatagac atgaccagaa aggctctggc ttcatccaga ccctgacgga tgtgttcatt
      781 cataaaaaag gatccatcac agagctgtta gaagagatca cccgacttat ggcaaacaca
      841 gaggtgatgc aggagggaaa accaaggaaa gtgaaccccg aaatccaaag caccctccgg
      901 aagaagctct atctgcaata aaaggaaagg cagtgacggc cttcctgcag ccgctttctc
      961 ggtcgccacc agtcttcaaa gatagttcct ggattcttca ttcatcacag cccttcatct
     1021 gtatcagttt cagagcaagc caggcaacca gagcacattg acgccacctt cctctgcctg
     1081 gactccctga ctctgttaat gcagcctcgc atggtcttcc tatagctacc tttcggctct
     1141 tttgcctcac caagccttcc ttttcctcca acgactcaac tgaaaatggt cattcctatt
     1201 tcagaggtag tagctttctg aacaatttct agaaacttcc aataaccaat taaggtcacc
     1261 actgtggaat ctgggcagta ggctggaaga gagaccagcc atgttggctt tacggtcatt
     1321 atgagtcaca acttaagacg ggtctcttct ttctggtctc tcttctcagg ctttcccagc
     1381 ttcctccttt tcttgttctt tgcctgggat tctttctata gctcatacac ccctcacttc
     1441 cctccagctg actttgaaat ggctttcgca tccgtctctc ttctcttccc cggaccctca
     1501 aggctcggcc tgaatgatct caactctgcc acagccagaa ttcttcctcc tctctctgca
     1561 taacctgtgg gggaattctc tctgaaacac gctgaaagat acaatgagcc ccgagaccaa
     1621 agctaaacga catcatattc ttgtttctca tgcttggtgt acaattcatc attgtaagga
     1681 aatcagggca ggacatacaa cagctagtga caataaatat tcttactcaa aatcaaagga
     1741 ctggagcatg aaacaatcac accaaaaccc ccagaggact tgagtagccc ttcctgcagt
     1801 ccagctagta actttcttat tccaaaaggt ttaccccagt aaagaagata ccatgataat
     1861 ggtgctggcc tctggtgatc tcagcagctt cttcagccca agcatggtga acacacacaa
     1921 atccttagtc aaattatcta taaatagttt tatttgttcc tgacagagtc tttgcttctc
     1981 tccaaaaccc cacgagctag gcctcaatga tcccaaaaca acctatgagt tctgtttcca
     2041 gaatttaatg gcttttccag tccactatac ctaaagcttt caaattcctc ccacaaaaca
     2101 tgtccaaatc ataaaagcca catggtcagg tctatcacag cagtgaccct acttccttgg
     2161 tatcaattcc tacgaaagag gtgtctctgg aagcctagag gagacacaaa gagcactaat
     2221 atttagagac caaaggcaag ccctacatct gtggtttttg atgtggtttt ttttatattt
     2281 ttatgactcc atccaatctg ccctcagata aattcatctc cttttctatg aaattgttct
     2341 cccagaaatg ctagcatcct ctctctctcc cctctgcctc tgtgtctttt gcccaataga
     2401 ccgattctcc aagcttaggt ctcccacatg cctgcctctt ctctttttcc ctttttccag
     2461 tgcctccccc tcaccactga ctccactcct aatgttcttt ttagcttatg ctgcggtctc
     2521 ttccatgatg aaatgctgta attacttttg tcagatgtca acctttgatt ggtgtaatga
     2581 gaattcagta aacatctgtt gaattttgcc
//
LOCUS       NM_001134464            1132 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus LLP homolog, long-term synaptic facilitation
            factor (Llph), mRNA.
ACCESSION   NM_001134464 XM_001081031 XM_006241425 XM_216898
VERSION     NM_001134464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Yu,N.K., Kim,H.F., Shim,J., Kim,S., Kim,D.W., Kwak,C., Sim,S.E.,
            Choi,J.H., Ahn,S., Yoo,J., Choi,S.L., Jang,D.J., Lim,C.S.,
            Lee,Y.S., Kang,C., Choi,S.Y. and Kaang,B.K.
  TITLE     A transducible nuclear/nucleolar protein, mLLP, regulates neuronal
            morphogenesis and synaptic transmission
  JOURNAL   Sci Rep 6, 22892 (2016)
   PUBMED   26961175
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_006241425.4, NM_001134464.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.19643.1,
                                           SRR26643285.27597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000007.1  57620999-57621056
            59-276              JAXUCZ010000007.1  57622198-57622415
            277-1132            JAXUCZ010000007.1  57625069-57625924
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1132
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /note="LLP homolog, long-term synaptic facilitation
                     factor"
                     /db_xref="GeneID:299818"
                     /db_xref="RGD:1308261"
     exon            1..58
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /inference="alignment:Splign:2.1.0"
     exon            59..276
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..446
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /note="LLP homolog, long-term synaptic facilitation
                     (Aplysia)"
                     /codon_start=1
                     /product="protein LLP homolog"
                     /protein_id="NP_001127936.1"
                     /db_xref="GeneID:299818"
                     /db_xref="RGD:1308261"
                     /translation="MAKSLRSKWKRKMRAEKRKKNAPRELNRLKSILKVDGDALMKDV
                     EEIATVVVPKHYQEKMQCDVAVDDEKDDMKMETEIKRNKKTLLDQHGQYPVWMNQRQR
                     KRLKAKREKKRGKSKAKAAKGLAW"
     misc_feature    72..416
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /note="Learning-associated protein; Region: Laps;
                     pfam10169"
                     /db_xref="CDD:462976"
     misc_feature    72..416
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /note="Learning-associated protein; Region: Laps;
                     pfam10169"
                     /db_xref="CDD:462976"
     exon            277..1132
                     /gene="Llph"
                     /gene_synonym="RGD1308261"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgtcg gagcttccgg ttggtgtccc actcgtggtg tgcggtcgtg tatctcaggc
       61 aaagcatggc taaaagcttg cggagtaagt ggaaaaggaa gatgcgcgct gagaagagaa
      121 agaagaatgc gccaagggaa cttaacagac tcaaaagtat cctcaaagtt gacggcgatg
      181 ctttaatgaa agatgttgaa gaaatagcca ctgtggtggt acccaaacat taccaggaga
      241 aaatgcagtg tgatgtcgct gtggatgatg aaaaggatga catgaaaatg gaaactgaaa
      301 ttaagagaaa caaaaagact cttctagacc agcatggcca gtacccagta tggatgaacc
      361 agaggcaaag aaaaagactg aaggccaaga gagaaaagaa acgggggaaa agcaaagcaa
      421 aggccgccaa gggcctggcc tggtagactc ttaaagactg gaaagggagg cagacgtgct
      481 ggtgcacccc tttaaccccc gcgctcaggg ggcggaggca ggtggatctc tgaattcggg
      541 gccagcctgg tctacagagt aactctagag aaaccctgtc ttgaaaaaaa caaccaaaca
      601 aacaaaaatc cagaagctat ttgttttcat attttagttt gaacttagtt ctataattca
      661 aagccaaaat aactccttcg ttttgggaac ttgaataaaa tgtctttgat aaaaggttac
      721 gtgaagttgt gattggatac tgcctgatat ggagtattgt gagacacctc aatcttgtga
      781 gcatgagtct agttatttga tgttacaaaa tggccattat acttagtgcc tcagagtaag
      841 cgtacttata tcaacagagt ttggacagaa agcttgagat cgtcatatta aaaaaatagg
      901 gtatcaaggg gctcaggagg actcaacttc tgtttgttgg gtgggtgact gaaaaccagc
      961 tcccagggat gtgccctctt gtggccttca ctgtcacccc ctcattcaca tgcacaagct
     1021 tcccacccac taataactga aagtctacaa aggacatcgg tggactttac aagtggtgct
     1081 tacttgaatt gcttattttt gataattcat aataaactat attttgtgtg ga
//
LOCUS       NM_001437972            2587 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus adaptor-related protein complex 1 associated
            regulatory protein (Ap1ar), transcript variant 1, mRNA.
ACCESSION   NM_001437972 XM_006233291
VERSION     NM_001437972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Maritzen,T., Zech,T., Schmidt,M.R., Krause,E., Machesky,L.M. and
            Haucke,V.
  TITLE     Gadkin negatively regulates cell spreading and motility via
            sequestration of the actin-nucleating ARP2/3 complex
  JOURNAL   Proc Natl Acad Sci U S A 109 (26), 10382-10387 (2012)
   PUBMED   22689987
REFERENCE   2  (bases 1 to 2587)
  AUTHORS   Schmidt,M.R., Maritzen,T., Kukhtina,V., Higman,V.A., Doglio,L.,
            Barak,N.N., Strauss,H., Oschkinat,H., Dotti,C.G. and Haucke,V.
  TITLE     Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin
            KIF5 complex
  JOURNAL   Proc Natl Acad Sci U S A 106 (36), 15344-15349 (2009)
   PUBMED   19706427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006233291.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1172135.1,
                                           SRR26360181.1980335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               JAXUCZ010000002.1  218983138-218983433 c
            297-345             JAXUCZ010000002.1  218967050-218967098 c
            346-372             JAXUCZ010000002.1  218966232-218966258 c
            373-398             JAXUCZ010000002.1  218964489-218964514 c
            399-495             JAXUCZ010000002.1  218960487-218960583 c
            496-594             JAXUCZ010000002.1  218959028-218959126 c
            595-650             JAXUCZ010000002.1  218957003-218957058 c
            651-724             JAXUCZ010000002.1  218956302-218956375 c
            725-853             JAXUCZ010000002.1  218955986-218956114 c
            854-2587            JAXUCZ010000002.1  218951104-218952837 c
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2587
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="adaptor-related protein complex 1 associated
                     regulatory protein"
                     /db_xref="GeneID:362037"
                     /db_xref="RGD:1311435"
     exon            1..296
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1116
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="isoform 1 is encoded by transcript variant 1; AP-1
                     complex-associated regulatory protein"
                     /codon_start=1
                     /product="AP-1 complex-associated regulatory protein
                     isoform 1"
                     /protein_id="NP_001424901.1"
                     /db_xref="GeneID:362037"
                     /db_xref="RGD:1311435"
                     /translation="MGNCCWTQCFGLLRREAGRLQRAGGGSKYFRTCPRGEHLTIEFE
                     NLVESDEGESPGSSHRPLTEEEIVDLQERHYDSIAEKQKDVDRKIQRELALQEEKLRL
                     EEEALYAAQREAARAARQRKLLEQEKQRIAQRYHPSSGDCQSVGPEDDFEASLRNIKS
                     QYEVFRSSRLSSDATVLTPNTESSCDLMTKTKSTSGNDDSTSLDLEWEDEEGMNRMLP
                     MRERSKTEEDILRAALKCSSKKGSNPTSASDDSNGLEWENDFVSAEMDDNGNSEYAGF
                     VNPVLELSESAIKQSDTDQQIR"
     misc_feature    289..1113
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="AP-1 complex-associated regulatory protein; Region:
                     AP1AR; pfam15745"
                     /db_xref="CDD:464841"
     misc_feature    289..1113
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /note="AP-1 complex-associated regulatory protein; Region:
                     AP1AR; pfam15745"
                     /db_xref="CDD:464841"
     exon            297..345
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            346..372
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            373..398
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            399..495
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            496..594
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            595..650
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            651..724
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            725..853
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
     exon            854..2587
                     /gene="Ap1ar"
                     /gene_synonym="RGD1311435"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggtgg caagcaggcc atgcggacgg ctggcgaccc gggaccccac ggccctgcgc
       61 tcgtccctcg cgcccgggta tccaggagcc cgcgggccta gcggcggcct ttgttcccta
      121 catcaccgtc tgccgagctc cggccggcgc ggatgcagct gctccgcctg ggctcgcgct
      181 cggggctgga ggaggagcgg cagctccagg cggcatgcga tggggaactg ctgctggacg
      241 caatgcttcg ggctgctccg ccgggaagcg ggtcggctgc agcgagcggg cggaggatcc
      301 aagtatttta gaacatgccc aagaggagag cacttgacca tagagtttga gaatcttgtg
      361 gagagcgatg agggggagag cccaggaagc agccataggc cacttactga ggaagaaatc
      421 gttgacttac aagagaggca ttatgactct attgctgaga agcagaaaga cgtggatagg
      481 aaaatccaga gggagttagc cttacaagag gagaagttaa gactagaaga agaagcttta
      541 tacgctgccc agcgtgaagc agccagggca gcaaggcagc gaaagctcct ggagcaagaa
      601 aagcagagaa ttgcccagcg ctatcatccc agcagtggag actgtcaaag tgtaggacca
      661 gaagacgact ttgaagcttc cttaagaaat ataaagtcac agtatgaagt ttttcgaagt
      721 agtagactct catctgatgc cacagtgttg acaccaaata cggaaagcag ctgtgaccta
      781 atgaccaaaa ccaaatcaac cagtgggaat gacgacagca cctccttaga cctggagtgg
      841 gaagatgaag aaggaatgaa taggatgctg cccatgagag agcgctccaa gacagaggaa
      901 gacatcctgc gggcagcgct gaagtgcagc agcaagaagg gcagcaaccc cacgtccgcc
      961 tccgatgact ccaacgggct ggagtgggag aacgactttg tcagtgccga gatggacgac
     1021 aatggcaatt ctgagtacgc ggggtttgtg aatcctgtgt tggaactgtc ggagtccgcc
     1081 atcaagcagt ctgatacaga tcagcagatc cggtagggtg aagctgtgac cttactcacc
     1141 aaatgttaac aatcagctag aatgtacagg tggcacgcca gggctctttg tgagggcagc
     1201 aaaataccac gtgacagatg cttgttttcc tggagggaca gctgagtgct ccagttggtg
     1261 tgagcgcagc atctgccttc tgcgtcccag gactgactca gtgattctga catatcaaac
     1321 actcatgcct ttctgttcac cccgtcaagt tctgcatctt aagtctgcat tcgttttcct
     1381 ctgaccgctt tactcagcct atcttcctat aacaatctaa aagtgttttt gttagttcag
     1441 catatgtaca ggcagcatga ggaggtgggg ggatcccagg aaggcagacc cttccagcag
     1501 aggctccttt ggttgctttt actcttcttg tcttgtagac agcaggaatt ggagatgacc
     1561 caagcatact gatgtgcggg cacacacgcg cacacacaca cacacgcaca cacacacaca
     1621 cacacacaca cacacacaca catcctaagc cctgcttcac tcaatctggt gacaggatta
     1681 aagatgcttc cagagtttgg acactttgag ttggtaataa tgaaaactaa tacataaaaa
     1741 tatatattta aaatttttac ttcctttcac atgccattat attggcttta aattgagatt
     1801 ttaagttttc actttcattt tttaaaaatt ctatatttcc agtgagtgat ctttgaaaga
     1861 tttttacaca gaacatattc tgtgagtgat ttaagaagac attaaaatac gggtatttca
     1921 aagtatataa cctcctttct gatatgaaag gtcccattgt attacccttt ccttcgcctt
     1981 gtagtgcaag gcgctgtgtg ggatggaact aaaatggcgg cgtattaaag acccatgtct
     2041 gaatctgtag agaaggccag ggctgggaag tgtttcctaa ctgcgttcct tgctttggct
     2101 gaggactgag tgtcactttg ggaagcacac ggcattctgt ctcccttgct gttttcctct
     2161 cctcagcagc gatggtgcat gctttcagca gtacagggcg gtcaggtaga aatagtcaag
     2221 ttcttgctgt gcgtgaaaac ttatgtggcc ctttcaatat ttgaactgct atacgatgac
     2281 atctataatt ttgtcatttt taaatctcat acaaataaat atactttgat atgtaaatat
     2341 gcattaggtt atgctattat ttatatctat cttaagattt aaattgtagg tgtgtcatgg
     2401 aaataattta aaggcactct gttcacattg cctgtgttca tgctttctaa ggtttatatt
     2461 acatcagatg tatatttttg gtttggcata agctactgtt gtaattttct tggctttttg
     2521 ttcataaaga attttctgaa ggaatggtaa cctttcaagg attgtgaata aacattttta
     2581 caattaa
//
LOCUS       NM_001437961            3615 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus midnolin (Midn), transcript variant 1, mRNA.
ACCESSION   NM_001437961 XM_006240914
VERSION     NM_001437961.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3615)
  AUTHORS   Obara,Y. and Ishii,K.
  TITLE     Transcriptome Analysis Reveals That Midnolin Regulates mRNA
            Expression Levels of Multiple Parkinson's Disease Causative Genes
  JOURNAL   Biol Pharm Bull 41 (1), 20-23 (2018)
   PUBMED   29311479
  REMARK    GeneRIF: These findings indicate that MIDN regulates the expression
            of a wide variety of genes, including multiple Parkinson's Disease
            causative genes and is associated with Parkinson's Disease onset.
REFERENCE   2  (bases 1 to 3615)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3615)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   4  (bases 1 to 3615)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006240914.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.24424.1,
                                           SRR26643296.19074.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN09345330,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000007.1  10208716-10208794   c
            80-710              JAXUCZ010000007.1  10206769-10207399   c
            711-798             JAXUCZ010000007.1  10205648-10205735   c
            799-861             JAXUCZ010000007.1  10205404-10205466   c
            862-1179            JAXUCZ010000007.1  10202930-10203247   c
            1180-1321           JAXUCZ010000007.1  10202592-10202733   c
            1322-1585           JAXUCZ010000007.1  10201724-10201987   c
            1586-3615           JAXUCZ010000007.1  10198761-10200790   c
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3615
                     /gene="Midn"
                     /note="midnolin"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
     exon            1..79
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            80..710
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    328..330
                     /gene="Midn"
                     /note="upstream in-frame stop codon"
     CDS             475..1863
                     /gene="Midn"
                     /note="isoform 1 is encoded by transcript variant 1;
                     midbrain nucleolar protein"
                     /codon_start=1
                     /product="midnolin isoform 1"
                     /protein_id="NP_001424890.1"
                     /db_xref="GeneID:314623"
                     /db_xref="RGD:1309629"
                     /translation="MEPQPGGARSCRRGAPGGACELSTTAESAAPMSLAIHSTTGTRY
                     DLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPT
                     VEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQ
                     HAPLQHRHVLAAAAAAAAAARGDSSIATPVSSPCRPVSSAARVPPVSSSPSSPVSPSP
                     VTAGTFQSHAASTTCPEQTDCSPPASSNTTSTPGSSPTPRSRKPGAVIESFVNHAPGV
                     FSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPASLTQLRCHAQCS
                     PASPAPDLTPKTTSCEKLATPSLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLL
                     LQQKRLRRKARRDARGPYHWTPSRKAGRSDSSSSGGGGSPSEATGLGLDFEDSVWKPE
                     VNPDIQSEFVVA"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     misc_feature    568..777
                     /gene="Midn"
                     /note="ubiquitin-like (Ubl) domain found in midnolin and
                     similar proteins; Region: Ubl_midnolin; cd01804"
                     /db_xref="CDD:340502"
     exon            711..798
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            799..861
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1179
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1321
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1585
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..3615
                     /gene="Midn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccggcac ggccacctct caccacgacc catacgcagg tcgtctggag cagtggtgac
       61 acaggaccta cggcacccga tcttgagagc agcggctgcg gctgttgcta agggaaggga
      121 cgcgcggggt agcacgaccc gagagggatc caggcaccgt gcgaaccagg atagctcgcc
      181 ccgtttctgt tggaccctcc ccgtgccgta ccctggtcgc tgtcaaacgc cctagaaacc
      241 ggatcgcaga ccccaccccg gggcgcaacc caaggatccc acgcgacccc gagcaccatt
      301 cggattcttg attgccggct ctattgctaa cgttgggacc ttccccaagg ggcgcacgca
      361 ctgctcttgt ccctgggcgc ccacggagca gaggaggacc ttgttttggc gggggagtcc
      421 cggcaaggat tggaggcgac ccgcaggccc ccagttatcc tgcgcgcgcc ggggatggag
      481 ccgcagcccg gcggcgcccg gagctgccgg cgcggggccc ccggtggcgc ctgcgagctg
      541 agcacgaccg cggaatcggc cgcacccatg agcctggcga tccacagcac tacggggacc
      601 cgctacgacc tttcggtgcc ccacgacgag accgtggagg ggctgcgcaa aaggctgtcc
      661 caacgcctca aagtacccaa ggaacgcctg gcgctgcttc acaaagacac ccggctcagt
      721 tcggggaagc tgcaggaatt cggcgtgggg gatgggagca agttgacgct cgtgcccacg
      781 gtggaagctg gcctcatgtc ccaggcctcg aggccggagc agtccgttat gcaagccctg
      841 gaaagtttga ctgagaccca ggtcagtgac tttttgtcag gccgatcgcc tttgaccctg
      901 gccctgcgag ttggggatca catgatgttt gtacaattgc aactggcagc ccaacacgcc
      961 ccactccagc accgccatgt gctggccgcg gctgccgcag ctgctgccgc tgcccgggga
     1021 gattccagca tagctacccc agtatcctca ccttgtcggc ccgtgtccag tgccgcccgt
     1081 gtccccccag tatccagcag cccttcttcg cctgtgtccc cctcacctgt caccgctggc
     1141 accttccaat cccatgcagc ctccacgact tgtcctgagc agacggactg ttctccaccc
     1201 gccagcagca acaccacatc caccccaggc agcagcccca ccccccgatc ccgcaaaccc
     1261 ggtgcagtca ttgagagctt cgtgaaccac gctccagggg tcttctcagg gaccttctct
     1321 ggcacactgc accccaactg ccaggatagt agtgggcggc ctcggcgtga catcggcacc
     1381 attctgcaga tactcaatga cctcctaagt gccacaaggc attaccaggg catgccggcc
     1441 tcactgaccc agctccgctg ccacgcgcag tgctcacctg cctcaccagc ccctgacctc
     1501 acccccaaaa ctacctcctg tgaaaagctg gcaaccccat cactgctcca gggccagagc
     1561 cagatccgaa tgtgcaagcc ccctggagac cgtctgcgac agacagagaa ccgtgccaca
     1621 cgctgcaaag tggaacgcct ccagctcctg ctgcagcaga agcgcctgcg aaggaaggca
     1681 cggcgggacg cccggggtcc ttaccactgg accccaagcc gcaaagctgg tcgtagtgac
     1741 agcagcagca gtgggggtgg aggtagcccc agcgaggcca caggcttggg cctcgacttc
     1801 gaggactccg tttggaagcc tgaagtcaac ccagacatcc agtccgagtt tgtggtggct
     1861 taaagaatcc ccttgggcct gaacatcctc taccccatac acggggcagg aggacgacac
     1921 agactggacg ctgagcggcc cagctctggg ggggaggggc aggaggtcac ctccattgcc
     1981 acttaccagc ctttctgatt cttttttagc tcctcccctg gttgtctacc ctgcatccct
     2041 ggtcacgtgc ccacctgtct ttcttccctt accatggtca gggcctctga gacagggccc
     2101 ttccctccca ccttctccag ttccaaatat gtagcagtct gttcccagat ggcccagacg
     2161 gaggaagcca cccaccccag cccttccgct ctgcctagct ctccccaccc ccttccataa
     2221 cccaattcag gtttttaaac tcaatgtaga ttctccaagc actttacaga tgagggttgg
     2281 ggaccccagg atgagtgcgc ccccctcccc ttcccctctg cagacttggc caccattcca
     2341 ggccagctgg ctcccccacc cctcccatcc cggaaagcta ctagatacac tcacagagga
     2401 tacctttgtc cacaatgccc acttaactca cagccttcct cctgcctcgg tctcccaagt
     2461 gctacaatga caggctttgc cactatgcct ggccgccctt gctcttgcca caagctaatt
     2521 cgatggagac tgctggagca ggggggctgt ttgttagtca ggtgggggat gctccttttc
     2581 ctcatgagag gaggctaggc ctcgcaccac cctccctgga cactggcctc ttggtctcct
     2641 ccctccacac acccacttat ttccctaacc ttccttccca atggggcttg agggactatt
     2701 tatagacttc atttttctga ctgagccagt aatggtttct atcctctagg ggaaagaaaa
     2761 gaaactgggg tagcttgtag gaggaggggc ccagagagac acccctgtac ctcttctcta
     2821 gtcccagcct gcagctgggg atgggaagag aggtgctgag ctgtgactgc attaacccca
     2881 ccctggggag ggcgggcgca ctgctgatcc acattggctc catggatgag agccctcccc
     2941 tcggattggg gcccatacag caggggtgat cttgtggggt ttttttcctc cacattttga
     3001 gatttttgtg ataaatggga tgtgtgccca cccctgatgc ctgtccacgt tgtctagact
     3061 ccacctgtcc acggttcctt tgatctaggc tgtgaaccca tccttgtctt cccccactgt
     3121 gtgtttaaac cgttaatggt ttgggatgtg aacgtgtgtt gactagctgt aaaggttttt
     3181 ggggtgggtg ggtgggaaag ggatcctgaa tggtagaggc caagtgagaa ttcggtttgg
     3241 ttttttgttt tgtttttttt tttctatttt ttttcccaaa aagaaaaggg aggggggaaa
     3301 gtgggtgcat tttttaagct gtcttgaaat acctatttaa atgtgtgttt tggttttttt
     3361 aggatttttt tttaagctgc ctgtgatatg tccgctgggc tgagggtgga gacctcaggc
     3421 aggagcccac ccatagttct ctcttccctg tgaagacatc cccagatagc attagccacc
     3481 ctcgggggga gggggagaat ccggctatgg ggaatccacc tcgcccaagt ctccttttat
     3541 tgaaataaaa tttgagggga aaagaaaaac cttacacgag caccgaattt caaataaatg
     3601 aaaacgagac atgaa
//
LOCUS       NM_001437968            4862 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus metadherin (Mtdh), transcript variant 2, mRNA.
ACCESSION   NM_001437968 XM_006241523
VERSION     NM_001437968.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Xiang,Y., Duan,Y., Peng,Z., Huang,H., Ding,W., Chen,E., Liu,Z.,
            Dou,C., Li,J., Ou,J., Wan,Q., Yang,B. and He,Z.
  TITLE     Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells
            Promote Vascular Calcification Through Astrocyte-Elevated Gene-1
  JOURNAL   Calcif Tissue Int 111 (1), 73-86 (2022)
   PUBMED   35195734
  REMARK    GeneRIF: Microparticles from Hyperphosphatemia-Stimulated
            Endothelial Cells Promote Vascular Calcification Through
            Astrocyte-Elevated Gene-1.
REFERENCE   2  (bases 1 to 4862)
  AUTHORS   Wang,Y., Zhang,W., Zhu,X., Wang,Y., Mao,X., Xu,X. and Wang,Y.
  TITLE     Upregulation of AEG-1 Involves in Schwann Cell Proliferation and
            Migration After Sciatic Nerve Crush
  JOURNAL   J Mol Neurosci 60 (2), 248-257 (2016)
   PUBMED   27351433
  REMARK    GeneRIF: AEG-1 was expressed mainly in Schwann cells of the distal
            sciatic nerve segment from injury.  Interference of AEG-1 inhibited
            both proliferation and migration of Schwann cells.
REFERENCE   3  (bases 1 to 4862)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4862)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4862)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   6  (bases 1 to 4862)
  AUTHORS   Emdad,L., Sarkar,D., Su,Z.Z., Randolph,A., Boukerche,H., Valerie,K.
            and Fisher,P.B.
  TITLE     Activation of the nuclear factor kappaB pathway by astrocyte
            elevated gene-1: implications for tumor progression and metastasis
  JOURNAL   Cancer Res 66 (3), 1509-1516 (2006)
   PUBMED   16452207
REFERENCE   7  (bases 1 to 4862)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 4862)
  AUTHORS   Kang,D.C., Su,Z.Z., Sarkar,D., Emdad,L., Volsky,D.J. and
            Fisher,P.B.
  TITLE     Cloning and characterization of HIV-1-inducible astrocyte elevated
            gene-1, AEG-1
  JOURNAL   Gene 353 (1), 8-15 (2005)
   PUBMED   15927426
REFERENCE   9  (bases 1 to 4862)
  AUTHORS   Britt,D.E., Yang,D.F., Yang,D.Q., Flanagan,D., Callanan,H.,
            Lim,Y.P., Lin,S.H. and Hixson,D.C.
  TITLE     Identification of a novel protein, LYRIC, localized to tight
            junctions of polarized epithelial cells
  JOURNAL   Exp Cell Res 300 (1), 134-148 (2004)
   PUBMED   15383321
REFERENCE   10 (bases 1 to 4862)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006241523.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.29757.1,
                                           SRR26360186.2146692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               JAXUCZ010000007.1  67192654-67193350
            698-799             JAXUCZ010000007.1  67208780-67208881
            800-884             JAXUCZ010000007.1  67220475-67220559
            885-1061            JAXUCZ010000007.1  67221235-67221411
            1062-1298           JAXUCZ010000007.1  67224204-67224440
            1299-1397           JAXUCZ010000007.1  67229897-67229995
            1398-1522           JAXUCZ010000007.1  67237466-67237590
            1523-1630           JAXUCZ010000007.1  67240852-67240959
            1631-1771           JAXUCZ010000007.1  67243630-67243770
            1772-1928           JAXUCZ010000007.1  67247056-67247212
            1929-4862           JAXUCZ010000007.1  67247886-67250819
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4862
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
     exon            1..697
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1999
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein LYRIC; lysine-rich CEACAM1 co-isolated protein;
                     metastasis adhesion protein"
                     /codon_start=1
                     /product="protein LYRIC isoform 2"
                     /protein_id="NP_001424897.1"
                     /db_xref="GeneID:170910"
                     /db_xref="RGD:620992"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDP
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENTITVTTEQLTTASFPVGSKKNKVSSGLNENITVNGGGWSEKSVKLSSQLSA
                     GEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKDWGRNWSDRSIFSGIGSTAEPVS
                     QSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSDWNAPAEEWGNWVDEDRASLLKS
                     QEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSITQDTEDLEKDTREEL
                     PVNTSKARPKQEKACSLKTMSTSDPVEVLIKNSQPIKTLPPAISAEPSVTLSKGDSDK
                     SSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET"
     misc_feature    335..1519
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     misc_feature    335..1519
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /note="Lysine-rich CEACAM1 co-isolated protein family;
                     Region: LYRIC; pfam15686"
                     /db_xref="CDD:434858"
     exon            698..799
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            800..884
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1298
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1397
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1522
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1630
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1771
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1928
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..4862
                     /gene="Mtdh"
                     /gene_synonym="Lyric"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgcca ttgttccgcc gggggaggac agcgaggcct ggcgctggcg ccccgacgcc
       61 acttagcggc cgcctctgga gacactctgt ccccgccgcc ccgtgtcctc ctggcggcgg
      121 cggcgtgagg ccgactggag ggagtgggaa ccctcggccc tccccgtggc ggcggcggcc
      181 acctattccc cactctggag tgaggggcgg ccgcgatgcg cttggcctga ggtgtcgcgg
      241 ccctcgtcgc ttcccacgac tgttccagcg gcgtctgtgc tccccggcgt catcccgaga
      301 gtctctgacg ggagggaaga tggctgcacg aagctggcag gacgaactgg ctcagcaggc
      361 cgaggagggc tctgcccggc tgcgggagtt gctctctgtc ggcctaggtt ttctgcgcac
      421 ggagttgggc ctcgacctgg ggttggagcc gaagcggtac ccgagctggg tgatcctggt
      481 gggcaccggc gctctcgggt tgctgcttct cttcctccta ggttacggct gggccgctgc
      541 ttgcgccggc gcccgcaaaa agcgaaggag cccgccccgc aagcgggagg aggtgacccc
      601 gccgactccg gcccccgagg acccagccca actgaagaat ctcagaagcg aggagcaaaa
      661 gaaaaagaac cggaagaagc tgcctgaaaa gcccaaacca aatggacgga ctgttgaaat
      721 acctgaagat gaagttgtta gaactccccg aagtataact gccaagcagc caccagagac
      781 agacaagaaa aatgaaaagt caaagaaaaa taagaagaag tcaaagtcag atgctaaagc
      841 agtgcaaaac agttcacgcc atgatggaaa ggaagttgat gaaggagcct gggaaactaa
      901 aattagtcac agagagaaac gacaacagcg taaacgtgat aaagtgctga ctgattctgg
      961 ttcattggat tcaactatcc ctgggataga aaataccatc acagttacca ccgagcaact
     1021 tacaactgca tcatttcctg ttggttccaa gaagaataaa gtttcttcag ggttgaatga
     1081 aaatattact gtcaatggag gaggctggag tgaaaagtct gtaaaactct cctcacaatt
     1141 gagtgcaggt gaggagaagt ggaactctgt cccacctgct tctgcaggca agagaaaaac
     1201 agagcagtct gcttggactc aagaccctgg tgatactaat gcaaatggga aagactgggg
     1261 aaggaattgg agtgatcgct caatattttc tggcattgga tctactgctg agccagtttc
     1321 tcagtctacc acttctgatt atcagtggga tggtagccgt aatcagcccc atatcgatga
     1381 tgaatggtct gggttaaatg gtttgtcttc tgctgatcct agctcagact ggaatgcacc
     1441 agcagaagag tgggggaact gggtagatga agatagagct tcacttctga agtcccagga
     1501 gccgatttct aatgatcaaa aggattcaga tgatgataag gaaaaaggag aaggagctct
     1561 tccaactgga aaatctaaaa agaaaaaaaa gaaaaagaag aagcaaggtg aagataactc
     1621 tatcacccag gacacagaag acctagaaaa ggacactaga gaagagcttc cagtgaatac
     1681 ctcgaaagcc cgtccaaaac aggagaaagc ttgttccctg aagaccatga gcactagtga
     1741 tccagttgaa gtactcatca aaaatagcca gcctatcaag actcttccac ctgctatctc
     1801 tgccgagcca tctgttactt tatcaaaggg tgactctgac aagagctctt cccaagtgcc
     1861 accgatgtta caagacacag acaaacccaa gtcaaatgct aagcaaaaca gtgtgcctcc
     1921 ctcacagacc aagtctgaaa ctaattggga atctccaaaa caaataaaaa agaagaaaaa
     1981 ggccagacgg gaaacgtgaa tttttttcct aaattggaca tgtgtttaca aacactgtct
     2041 tgaagattat gctgtttatg caataatttg tgaacatgta cagagtttta tataaattta
     2101 aaccaatttt taaaacaaaa ctgaacacaa ccaccataaa atggaatcaa aggaaagtta
     2161 atttatgaaa ttaagaggtc aacaatacat actacagtgc tggaagacac tcgggagaga
     2221 ctttgcaatt gaacgagaat gatcataatt taagaatatt atcctggttt tacaacagtt
     2281 ccctgtttac aacagattgt gccctgtttc atctgcagct gaggaataat ggattctgat
     2341 tagagagaag gctgcctaga agccagtagg caagtccttg gatcttatgc acgaccttag
     2401 accatttgaa tctgttttat gcttaaatca aagtgctttg attaaatgca tacctgccat
     2461 atctttacct atttgttgta gcaatttgta ttaaaagaat cacaagtgca aataaaaggt
     2521 catttatcat ttatttaact aaactgtctt ggtttagttt acagttcttt aaaagttcta
     2581 aattaaaaca ttgaaaaatg caattgacag acacctgtat ggcttacaaa gttatttttg
     2641 atagtcttgc attacttgaa ttattcaaag taacagtata ttttaaatta agaaaggtaa
     2701 atatattatt tgtttgatac attaagactg agactaacag tgctcttgtt tatgatttga
     2761 aaacttttca ggcaaaatcc aacttaatat ttttcctttc cctagcaatt ttccagtgtc
     2821 aactcttagt tgctagtaat tttttacctt aaaaataaag taattcgcaa cttttgagca
     2881 tacgacggag aatggaaaag tagtcagaca gctttaattg acattgtgga gacctccggt
     2941 tatcaggaat acattttttt actgccttaa cctcctgtag tgcgtagaat atgcatcaat
     3001 ttcttgaagg ggattcatgt ttttataaga attttcatgt aactattgca attgtggtca
     3061 aaaaaaggaa cattttctgc ttgaaactgt gttgatttaa atgacgtatg atctgtcacc
     3121 attttcaggc actgtgtgat tcctaggaaa gtggcaggcc tctctgtaac tgttaatagt
     3181 gcatgctcgg ccatgtacac tgtaaatagc ctttaccaaa cgtgtttgac aaggaccata
     3241 attaacatca ctttagtgaa ttgtaatttt aaaaaagcca tgatttattg atgtgagcgg
     3301 cttgttttcg tgtggcgcca ggaatgaacc tgtttaaaag ctataaccaa tggtactgat
     3361 ctatccatta aatactgtcc ttatatttga ctgtagttta atagtattgt caactaggaa
     3421 agctacaaga tgtaaaatgg ttttcgttct gttgaagact ggccttatta atggacagct
     3481 ttcctcagaa gtgattaaca acttttttta ttgggtgtta acatctgttt caggaacatg
     3541 gcagtatgtt tacatgttgt cagaagtttt gtttgattga atgggatttc taaattaact
     3601 tacttgttta aataaattca gaaatggata gcattgtttt tatttgcttc actattgggg
     3661 taaataatag ctgatgtgcc aggaatggag ccttcagatg gctgctgtga gcttcatgtt
     3721 ccctcagggg atgccacgct atgtctcaag gagaagttga tagggagtct gtaattacag
     3781 agtgtgccaa aaggtcagtg ctcacaagtt taattgaact ctctcaactc tacctcactg
     3841 ttccttttcc ttataattct ctgggctaga acaaataaga aactttattt ttcacttcaa
     3901 tgtctccgga tgcaatcact tataggaggt ggcacctaca ccaggtagca agaataccgt
     3961 ctttttgcag aggaatatat aatgggggga agcagagtga cactgggtgg gtcagtgtgg
     4021 aggtggcctc tatgcctgcc ttctctctgg cttgcgagcc aggcagtgtg tgtgtgtgtg
     4081 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgaaggag gcaggtatat
     4141 gagtgaaaat taatcattca ctgctctttg cctctgtata gatctttgtg tggcagggca
     4201 gggatttctt gtcactgatc agaggaactg gtttctgcca tcaactcaga aaactctgag
     4261 atttaggtaa tggtgattag agagtggcaa cagaagactg ggtattctct gctggccgga
     4321 atgagggccc ctgatgccac ctgtttcccc aaaaggctct ctgaaaagcc tttctgttgt
     4381 ggggcggggc atgggcatgt cagagttctc caactgcatt gtccctatct tataccctaa
     4441 attgagaaac agttgagaga gtccaaaaag aaagttgaaa taaaatatca ttaatgtaat
     4501 ttaccttgtt taatttgtgc atgcatttta ttggggaggg gaggttggaa taatttatct
     4561 aaaactaatg gtattatttc ataggctaat ccagtttgta tttgagttaa agatcccaga
     4621 gggtagtaat taattacaga gtttagtttt tcttaattaa aagcagtcct ctattaatat
     4681 agtatgaaat gtcaaaattt aggatttaag tttaaggtct aatggctatt ttaaagtttt
     4741 tctgtaaact cattgcacaa actggaattg gaattgcttt caaaagactt gggaaatgaa
     4801 aatgtgtcat gtaagatgca ctgagtgttg taaataaaat actgtttttg ttttgtttaa
     4861 aa
//
LOCUS       NM_001437967            6262 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus amylo-alpha-1,6-glucosidase and
            4-alpha-glucanotransferase (Agl), transcript variant 2, mRNA.
ACCESSION   NM_001437967 XM_006233229
VERSION     NM_001437967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6262)
  AUTHORS   Cheng,A., Zhang,M., Gentry,M.S., Worby,C.A., Dixon,J.E. and
            Saltiel,A.R.
  TITLE     A role for AGL ubiquitination in the glycogen storage disorders of
            Lafora and Cori's disease
  JOURNAL   Genes Dev 21 (19), 2399-2409 (2007)
   PUBMED   17908927
REFERENCE   2  (bases 1 to 6262)
  AUTHORS   Lucchiari,S., Pagliarani,S., Salani,S., Filocamo,M., Di Rocco,M.,
            Melis,D., Rodolico,C., Musumeci,O., Toscano,A., Bresolin,N. and
            Comi,G.P.
  TITLE     Hepatic and neuromuscular forms of glycogenosis type III: nine
            mutations in AGL
  JOURNAL   Hum Mutat 27 (6), 600-601 (2006)
   PUBMED   16705713
REFERENCE   3  (bases 1 to 6262)
  AUTHORS   Lees,S.J., Chen,Y.T. and Williams,J.H.
  TITLE     Glycogen debranching enzyme is associated with rat skeletal muscle
            sarcoplasmic reticulum
  JOURNAL   Acta Physiol Scand 181 (2), 239-245 (2004)
   PUBMED   15180797
REFERENCE   4  (bases 1 to 6262)
  AUTHORS   Becker,K.G., Barnes,K.C., Bright,T.J. and Wang,S.A.
  TITLE     The genetic association database
  JOURNAL   Nat Genet 36 (5), 431-432 (2004)
   PUBMED   15118671
REFERENCE   5  (bases 1 to 6262)
  AUTHORS   Schliselfeld,L.H. and Danon,M.J.
  TITLE     Inverse relationship of skeletal muscle glycogen from wild-type and
            genetically modified mice to their phosphorylase a activity
  JOURNAL   Biochem Biophys Res Commun 290 (2), 874-877 (2002)
   PUBMED   11785984
REFERENCE   6  (bases 1 to 6262)
  AUTHORS   Popova,I.A., Presnova,V.N. and Lavrenova,T.P.
  TITLE     [Effect of biogenic amines on glycogen degradation in isolated rat
            hepatocytes]
  JOURNAL   Vopr Med Khim 38 (2), 30-33 (1992)
   PUBMED   1413626
REFERENCE   7  (bases 1 to 6262)
  AUTHORS   Chen,Y.T., He,J.K., Ding,J.H. and Brown,B.I.
  TITLE     Glycogen debranching enzyme: purification, antibody
            characterization, and immunoblot analyses of type III glycogen
            storage disease
  JOURNAL   Am J Hum Genet 41 (6), 1002-1015 (1987)
   PUBMED   2961257
REFERENCE   8  (bases 1 to 6262)
  AUTHORS   Satoh,K. and Sato,K.
  TITLE     Glycogen-binding protein components of rat tissues
  JOURNAL   Biochem Biophys Res Commun 96 (1), 28-33 (1980)
   PUBMED   6449198
REFERENCE   9  (bases 1 to 6262)
  AUTHORS   Vaillant,R., Bourgeois-Victor,P. and Fairand,A.
  TITLE     [Development and control of liver amylo-1,6-glucosidase activity in
            the fetal rat]
  JOURNAL   Can J Biochem 57 (10), 1245-1249 (1979)
   PUBMED   120213
REFERENCE   10 (bases 1 to 6262)
  AUTHORS   Mannan,A., Noujaim,A.A., Wiebe,L.I., Secord,D.C. and
            Silverberg,D.S.
  TITLE     Carbohydrate metabolism in the chronically uremic rat
  JOURNAL   Clin Biochem 8 (3), 194-198 (1975)
   PUBMED   807434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006233229.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.872952.1,
                                           SRR26360186.2660540.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000002.1  207445724-207445765 c
            43-192              JAXUCZ010000002.1  207445024-207445173 c
            193-403             JAXUCZ010000002.1  207432237-207432447 c
            404-570             JAXUCZ010000002.1  207431064-207431230 c
            571-774             JAXUCZ010000002.1  207430041-207430244 c
            775-956             JAXUCZ010000002.1  207428219-207428400 c
            957-1068            JAXUCZ010000002.1  207427901-207428012 c
            1069-1192           JAXUCZ010000002.1  207426881-207427004 c
            1193-1295           JAXUCZ010000002.1  207426327-207426429 c
            1296-1393           JAXUCZ010000002.1  207426140-207426237 c
            1394-1533           JAXUCZ010000002.1  207424668-207424807 c
            1534-1721           JAXUCZ010000002.1  207424075-207424262 c
            1722-1845           JAXUCZ010000002.1  207423001-207423124 c
            1846-2009           JAXUCZ010000002.1  207422001-207422164 c
            2010-2111           JAXUCZ010000002.1  207421664-207421765 c
            2112-2267           JAXUCZ010000002.1  207421415-207421570 c
            2268-2418           JAXUCZ010000002.1  207421147-207421297 c
            2419-2543           JAXUCZ010000002.1  207419662-207419786 c
            2544-2656           JAXUCZ010000002.1  207419461-207419573 c
            2657-2791           JAXUCZ010000002.1  207418997-207419131 c
            2792-2922           JAXUCZ010000002.1  207414329-207414459 c
            2923-3059           JAXUCZ010000002.1  207410150-207410286 c
            3060-3193           JAXUCZ010000002.1  207409767-207409900 c
            3194-3369           JAXUCZ010000002.1  207408672-207408847 c
            3370-3472           JAXUCZ010000002.1  207406000-207406102 c
            3473-3698           JAXUCZ010000002.1  207401965-207402190 c
            3699-3810           JAXUCZ010000002.1  207401517-207401628 c
            3811-3946           JAXUCZ010000002.1  207399100-207399235 c
            3947-4059           JAXUCZ010000002.1  207397562-207397674 c
            4060-4271           JAXUCZ010000002.1  207396758-207396969 c
            4272-4369           JAXUCZ010000002.1  207395048-207395145 c
            4370-4457           JAXUCZ010000002.1  207393895-207393982 c
            4458-4591           JAXUCZ010000002.1  207393659-207393792 c
            4592-6262           JAXUCZ010000002.1  207390821-207392491 c
FEATURES             Location/Qualifiers
     source          1..6262
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..6262
                     /gene="Agl"
                     /note="amylo-alpha-1,6-glucosidase and
                     4-alpha-glucanotransferase"
                     /db_xref="GeneID:362029"
                     /db_xref="RGD:1306376"
     exon            1..42
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            43..192
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Agl"
                     /note="upstream in-frame stop codon"
     CDS             111..4709
                     /gene="Agl"
                     /note="amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
                     (glycogen debranching enzyme, glycogen storage disease
                     type III); amylo-1,6-glucosidase,
                     4-alpha-glucanotransferase; amylo-alpha-1, 6-glucosidase,
                     4-alpha-glucanotransferase"
                     /codon_start=1
                     /product="glycogen debranching enzyme"
                     /protein_id="NP_001424896.1"
                     /db_xref="GeneID:362029"
                     /db_xref="RGD:1306376"
                     /translation="MEHSKQIRILLLNEMEKLEKTLFRLEQGFELQFRLGPTLQGKAV
                     TVYTNYPFPGEAFNREKFRSLDWENPTEREDDSDKYCKVHLQQSGSFQYYFLQGQEKS
                     GGGYIVVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHF
                     TPLQALGLSRSCYSLADQLELNPDFSRPNRRYTWDDVGQLVEKLKREWNILCITDVVY
                     NHTAANSKWIHEHPESAYNLVNSPHLKPAWVLDRALWHLSCDVADGKYREKGVPALIE
                     NDHHMNCIRKIIWEDIFPRIQLWEFFQVDVQKAVEQFRRLLSQENRRVTKSEPKEHLK
                     IIQDPEFRRLGCAVDMNIALATFIPHDNGPAAIEECCNWFRKRLEELNSEKHHLTSCH
                     QEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFTFPFEEMALSAEESLLHRPD
                     KACFLMAHNGWVMGDDPLRNFAEPGSNVYLRRELICWGDSVKLRYGNKPEDCPYLWAH
                     MKKYTEITATHFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAELFTGSEDLDNI
                     FVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALFMDI
                     THDNECPIVHRSAYDALPSTTVVSMACCASGSTRGYDELVPHQISVVAEERFYTKWNP
                     GASPSDTGDVSIHSGIIAARCAINRLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIH
                     QSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTKPYRKDENSING
                     MPNMTVELRERIQLHESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHA
                     QVAVGILRNHLTQFSSHFKSGSLAVDNSDPILKIPFASIASKLTLAELNQVLYRCESE
                     EQEDGGGCYDIPNWSSLKYAGLQGLMSVLAEIRPKNDLGHPFCENLRSGDWMIDYVSG
                     RLISRSGSIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDVAWKQMSSFV
                     QNGSTFVKHLSLGSVQMCGVGKCPCLPLLSPSLLDVPCRLNEITKEKEQCCASLAAGL
                     PHFSSGLFRCWGRDTFIALRGMLLVTGRYLEARNIILAFACTLRHGLIPNLLGEGTYA
                     RYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLFEVI
                     QEAMQRHMQGIQFRERNAGPQIDRNMKDEGFNITVGVDEETGFVYGGNRFNCGTWMDK
                     MGESDRARNRGIPATPRDGSAVEIVGLCKSAVRWLLELSKKNIFPYHEVRVRRHGKVV
                     AVSYDEWNRKIQNSFEKLFHVSEDPSDPNEKHPNLVHKRGIYKDSYGASSPWCDYQLR
                     PNFTIAMVVAPELFTAEKAWKALEIAEGKLLGPLGMKTLDPDDMVYCGVYDNALDNDN
                     YNLARGFNYHQGPEWLWPIGYFLRAKLYFSKMMGPETAAKTVFLVKNVLSRHYVHLER
                     SPWKGLPELTNENGQYCPFSCETQAWSMAAVLETLYDL"
     misc_feature    174..4706
                     /gene="Agl"
                     /note="glycogen debranching enzymye; Region:
                     glyc_debranch; TIGR01531"
                     /db_xref="CDD:273673"
     misc_feature    174..4706
                     /gene="Agl"
                     /note="glycogen debranching enzymye; Region:
                     glyc_debranch; TIGR01531"
                     /db_xref="CDD:273673"
     exon            193..403
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            404..570
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            571..774
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            775..956
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1068
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1192
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1295
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1393
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1533
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1721
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1845
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2009
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2111
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2267
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2418
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2543
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2656
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2791
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2922
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3059
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3193
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3369
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3472
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3698
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3810
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3946
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4059
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4271
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4369
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4457
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4458..4591
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..6262
                     /gene="Agl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacccggct cccgctcccg acgccgcacg tctatcccgc ttgggtaact cattccactt
       61 cggagttctt ttaattctac ggaaagagtt cagatccccc agaggccaaa atggaacaca
      121 gtaagcagat tcgaatttta ctattgaacg aaatggagaa gctagagaag accctcttca
      181 gacttgagca aggatttgaa ctacagttcc gattaggccc aactttacaa ggaaaagctg
      241 ttactgttta tacaaattac ccatttcctg gagaagcatt taatcgagaa aaattccgtt
      301 ccttggattg ggaaaaccca acagagagag aagatgattc ggacaaatac tgtaaagttc
      361 atctgcagca gtctgggtct tttcagtact acttccttca aggacaggag aaaagtggcg
      421 gaggttacat agttgtggat cctattctgc gagttggagc tgataatcac gtgctaccct
      481 tggattgtgt tactctgcag acatttttag caaagtgttt aggacccttt gatgagtggg
      541 aaagccgact acgggtggca aaggagtcag gctacaacat gattcacttc accccgctgc
      601 aggctctcgg actgtccagg tcatgctatt cccttgccga tcagttagaa ttaaatcctg
      661 acttctcaag gcccaataga agatacacct gggatgatgt tgggcagcta gtagagaagc
      721 tgaagaggga gtggaacatt ctttgtatta ccgatgtggt ctacaatcat actgctgcta
      781 atagtaagtg gatccatgag catccagaat ctgcgtacaa tcttgtaaat tctccacact
      841 tgaaacctgc ctgggtccta gacagagcgc tctggcattt gtcctgtgat gttgcagatg
      901 ggaagtacag agaaaaagga gtccctgctc taattgaaaa tgaccatcac atgaactgca
      961 ttcggaaaat aatttgggag gacattttcc caaggattca gctctgggag tttttccaag
     1021 tagatgttca gaaagcggtt gaacaattta gaagactgct ctctcaagaa aacagaagag
     1081 taactaagtc tgaaccgaaa gaacatctta aaattattca ggaccccgaa ttcaggcggc
     1141 tgggctgtgc tgtagatatg aacattgctc tggcgacctt tataccacat gacaatgggc
     1201 cagctgcaat tgaagagtgc tgtaattggt tccgtaagag actcgaggag ttaaattcag
     1261 agaaacacca cctcaccagc tgtcatcagg aacaggccgt taattgtctt ttgggaaacg
     1321 tgttttatga acggctggcg ggccatggcc ctaaactagg acccgtcacc aggaagtacc
     1381 ctttagttac caggtatttt actttcccct ttgaagaaat ggccttgtct gcagaagagt
     1441 ccctgctcca ccgcccagat aaagcttgct ttctgatggc acacaatggc tgggtgatgg
     1501 gcgatgaccc gcttcggaac tttgctgagc caggttccaa cgtttattta aggagagaac
     1561 ttatttgctg gggtgacagt gtgaaattgc gctatgggaa caaaccggag gactgccctt
     1621 acctgtgggc acacatgaag aaatacactg agatcactgc cactcacttc cagggagtgc
     1681 gccttgacaa ctgccactcc acgcctctcc acgtggctga gtacatgctg gatgctgcta
     1741 ggaaattaca gcccaatctt tatgtagtgg ctgagctgtt cacaggaagc gaagatctgg
     1801 acaatatctt cgttactaga ctgggcatca gttccttaat aagagaggca atgagcgcat
     1861 ataacagtca cgaagagggc agattggtct accggtacgg aggggagccc gtcggatcct
     1921 tcgttcagcc ctgtttgagg cctcttatgc cagctatcgc gcatgccctg tttatggaca
     1981 tcacccacga taatgagtgt ccaattgtgc acagatcagc ctatgatgcg cttccaagta
     2041 ccacagttgt ctccatggcg tgttgtgcta gtggaagtac aagaggctac gacgagctag
     2101 tgcctcatca gatttcagtg gttgctgaag aacggtttta cactaagtgg aatcctgggg
     2161 catccccatc ggatacagga gatgttagca tccacagtgg gattattgca gccagatgtg
     2221 ccatcaacag actccatcaa gagcttggag ccaagggttt cattcaagtg tatgtggatc
     2281 aagtggatga agacatagtg gcagtaacca ggcactcacc aagcatccat cagtctgttg
     2341 tggctgtatc gagaacggct tttaggaatc ccaagacttc attttacagc aaagaagtgc
     2401 ctcaaatgtg catccctggc aaaattgaag aggtagttct ggaagctaga actattgaga
     2461 ggaatacaaa accttatagg aaagatgaga attcaatcaa tggaatgccg aacatgacag
     2521 tggaacttag agaacgtatc cagcttcatg aaagtaaaat tgtcaaacaa gctggagttg
     2581 ccacaaaggg tcccaatgaa tatattcagg aaatagaatt tgaaaaccta tctccaggaa
     2641 gtgttattat attcagagtt agccttgatc cacatgcgca agttgctgtt ggaattcttc
     2701 gaaatcacct gacccaattc agctcccatt ttaaatctgg aagccttgct gttgacaact
     2761 cggatcctat attaaaaatc cccttcgctt ccattgcctc taaattgact ttggctgagc
     2821 taaatcaggt actttaccga tgtgaatcag aagaacaaga agacggtgga ggttgctatg
     2881 atataccaaa ctggtcgtcc cttaagtatg caggtctgca aggattaatg tccgtgctgg
     2941 cagaaataag accaaagaat gacttggggc atcccttctg tgaaaacttg aggtctggag
     3001 actggatgat cgactacgtc agtggccggc taatctcacg atcagggagt attgctgaag
     3061 ttggaaaatg gttgcaggct atgttcttct acctgaagca gatcccgcga tatctcatcc
     3121 catgttactt tgatgctata ttaatcggtg catataccac tctgctggat gtagcctgga
     3181 aacagatgtc aagctttgtt cagaatggct cgaccttcgt gaagcacctg tccctgggtt
     3241 ctgtccagat gtgtggagtc gggaagtgtc cttgtctgcc gctgctttca ccctcactcc
     3301 tggatgtgcc gtgcaggtta aatgagatca cgaaggagaa agagcagtgc tgtgcttcct
     3361 tggctgcagg cttacctcac ttttcttctg gtctttttcg ctgctggggg agggatactt
     3421 tcattgcact tcgagggatg ctgctggtta ctggtcgcta cctagaagcc aggaatatta
     3481 ttttagcatt tgcttgtacc ctgaggcatg gtctcattcc taacctcctt ggcgaaggaa
     3541 cgtatgccag gtacaactgt cgtgatgccg tgtggtggtg gctgcagtgc attcaggact
     3601 attgcaagat ggttccaaat ggtctagaca tcctcaaatg cccagtttcc agaatgtatc
     3661 caacagatga ctctgcacct ttgcctgctg ggactctgga tcagcctttg tttgaagtca
     3721 tacaggaagc tatgcagagg cacatgcaag gcattcagtt ccgagagcgg aatgccggtc
     3781 cacagatcga tcgaaacatg aaggatgagg gtttcaacat aaccgtgggg gttgatgaag
     3841 aaacaggatt tgtttatgga ggaaatcgct tcaactgtgg cacatggatg gataaaatgg
     3901 gagagagtga cagagctaga aacagaggga tcccagccac cccaagagat gggtctgctg
     3961 tggaaatcgt gggcttgtgt aaatctgctg ttcgttggtt gctggaattg tccaagaaaa
     4021 acatttttcc ttatcatgaa gtcagagtaa gaagacatgg aaaggttgta gcagtctcct
     4081 atgatgagtg gaacagaaaa atacaaaaca gttttgaaaa gctctttcat gtttccgaag
     4141 acccttcaga tcctaacgag aagcatccga atctggttca caagcggggc atctacaagg
     4201 acagctacgg tgcgtcaagt ccttggtgtg actatcagct caggcccaac tttaccatag
     4261 caatggtcgt ggcccctgag ctctttactg ctgaaaaggc ttggaaggct ttggaaattg
     4321 cagaaggaaa attgcttggt ccccttggca tgaagacttt ggatccagat gacatggttt
     4381 actgtggagt ctatgacaat gccttagaca atgacaacta caaccttgcc agaggtttca
     4441 attaccacca aggacctgag tggctatggc cgattgggta ttttcttcgt gcaaagttgt
     4501 atttttccaa aatgatgggc ccagagactg ctgcgaagac tgtatttttg gttaaaaatg
     4561 ttctttctag acattatgtt catcttgaga gatccccatg gaaaggactt ccagagctca
     4621 ccaatgagaa tggccagtac tgccctttca gctgtgagac acaggcatgg tcgatggctg
     4681 ctgttctcga aaccctctat gatctatagt tggctcgtag atacttagta attgtgtgaa
     4741 cacttgacat tattgaatgc aaggtcataa ggaaatgtaa gctcaactca ttttaaaaat
     4801 cccattcata gccagggagt ggtggtgtac accgttgatc ccagcactcg ggaaacagaa
     4861 gcaggcagat ctcttgagtt cgatagaggc cagcctggtc tacaaagaaa gttcctggac
     4921 agccaggggt acacagagaa accctgtgtc gaaaaaccaa aaattaaaca aacaaaaaaa
     4981 aatagatttt ttttggcttt ttttcttaaa gaatatcatg tgtactgggg attacacgaa
     5041 ggacctcatg tatgttagac aagcattcta ccaactgaac ttcatcctgt gtcctatttt
     5101 ttctatattc ttttgatttg aatcgaagaa aaatgatctt ttcccataga aggttacagg
     5161 gaaaagtatt cttcaaagca gggtttaaaa acagtgtatt atcttcagtt tagaggaaga
     5221 agtcctgctg tctgttggca cactccacag gctgtgtcat gaatgctcta acgtttgcta
     5281 cagcagtctt aataccatgc ctaatgcagt cagtgcacac ttgttaaatg ttttatgaat
     5341 gtggaattat ggaagtttcc acccacagta tatgttcata gctggagcac agagcttcaa
     5401 aatgtgcttt atttttcatg gacaagttat gtttttaata tagtaaatgc caactatact
     5461 taatatagcc tatttgtgtt aaagagtaat tggtcgtaat aaaacagacc actagaacat
     5521 aagacaattc tgtaaaatta gttctaattt cccactatga gatagtttac attttcaaaa
     5581 tggaaattac tgggcatatt tatgaaattt ttcaaggggg aaaaaagctt agagctgtac
     5641 ttggtgacac agcttgctta gcatggtcaa ggccttgagt tctatcccta aaaccatcaa
     5701 gaaaggaagg aaggagtata agaggggagg gagggaggaa agaaagaggg aagatttaaa
     5761 atagagccat attaggttat caacaatagg gtcaccatcc acctcagaaa atccttaggg
     5821 tacagtgctt atactgagga ctgttgatga aaggctggtg ctgtgttggg catggtctat
     5881 gtgaaagtct aggaggtgta ttttacctta tcccagccac agtaattaga ctggaaaagg
     5941 ataatggcca tttgactgaa gaactcttag gtgcaacgct tcgttcctgt gtgatgctgc
     6001 agaaagtttc ccaaacggtc cgtgccttgg tttgtcacat atcaaaccaa tcttactctg
     6061 ctaagtgaaa ggtaaactta gcagttgaac cagcatgctg tggtattgta gtgagttttc
     6121 atagatgact gaggaggcag ggagcctgtc atttagtaca tcacctaagt ggtaatcatt
     6181 tccactgtgt cctaaacggc tctgagtact gagcaaatgt gtatatgtct gtgtgtcaaa
     6241 ataaaagttt ttttttaaag ga
//
LOCUS       NM_001437918            3858 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus adenosylhomocysteinase-like 1 (Ahcyl1),
            transcript variant 2, mRNA.
ACCESSION   NM_001437918 XM_008761405
VERSION     NM_001437918.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3858)
  AUTHORS   Harvey,K.E., LaVigne,E.K., Dar,M.S., Salyer,A.E., Pratt,E.P.S.,
            Sample,P.A., Aryal,U.K., Gowher,H. and Hockerman,G.H.
  TITLE     RyR2/IRBIT regulates insulin gene transcript, insulin content, and
            secretion in the insulinoma cell line INS-1
  JOURNAL   Sci Rep 12 (1), 7713 (2022)
   PUBMED   35562179
  REMARK    GeneRIF: RyR2/IRBIT regulates insulin gene transcript, insulin
            content, and secretion in the insulinoma cell line INS-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3858)
  AUTHORS   Borth,H., Weber,N., Meyer,D., Wartenberg,A., Arlt,E., Zierler,S.,
            Breit,A., Wennemuth,G., Gudermann,T. and Boekhoff,I.
  TITLE     The IP3 R Binding Protein Released With Inositol
            1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and
            Spermatozoa
  JOURNAL   J Cell Physiol 231 (5), 1114-1129 (2016)
   PUBMED   26439876
  REMARK    GeneRIF: The present study documents that IRBIT is expressed in
            Leydig and Sertoli cells.
REFERENCE   3  (bases 1 to 3858)
  AUTHORS   Ando,H., Hirose,M., Gainche,L., Kawaai,K., Bonneau,B., Ijuin,T.,
            Itoh,T., Takenawa,T. and Mikoshiba,K.
  TITLE     IRBIT Interacts with the Catalytic Core of Phosphatidylinositol
            Phosphate Kinase Type Ialpha and IIalpha through Conserved
            Catalytic Aspartate Residues
  JOURNAL   PLoS One 10 (10), e0141569 (2015)
   PUBMED   26509711
  REMARK    GeneRIF: IRBIT forms signaling complexes with PIPKIalpha and
            NBCe1-B, whose activity is regulated by PI(4,5)P2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3858)
  AUTHORS   Park,S., Shcheynikov,N., Hong,J.H., Zheng,C., Suh,S.H., Kawaai,K.,
            Ando,H., Mizutani,A., Abe,T., Kiyonari,H., Seki,G., Yule,D.,
            Mikoshiba,K. and Muallem,S.
  TITLE     Irbit mediates synergy between ca(2+) and cAMP signaling pathways
            during epithelial transport in mice
  JOURNAL   Gastroenterology 145 (1), 232-241 (2013)
   PUBMED   23542070
REFERENCE   5  (bases 1 to 3858)
  AUTHORS   He,P., Klein,J. and Yun,C.C.
  TITLE     Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated
            by inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein
            kinase II
  JOURNAL   J Biol Chem 285 (36), 27869-27878 (2010)
   PUBMED   20584908
  REMARK    GeneRIF: IRBIT is critically involved in mediating activation of
            NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases
            II-dependent pathway.
REFERENCE   6  (bases 1 to 3858)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   7  (bases 1 to 3858)
  AUTHORS   Yang,D., Shcheynikov,N., Zeng,W., Ohana,E., So,I., Ando,H.,
            Mizutani,A., Mikoshiba,K. and Muallem,S.
  TITLE     IRBIT coordinates epithelial fluid and HCO3- secretion by
            stimulating the transporters pNBC1 and CFTR in the murine
            pancreatic duct
  JOURNAL   J Clin Invest 119 (1), 193-202 (2009)
   PUBMED   19033647
REFERENCE   8  (bases 1 to 3858)
  AUTHORS   He,P., Zhang,H. and Yun,C.C.
  TITLE     IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3
            activity in response to calcium
  JOURNAL   J Biol Chem 283 (48), 33544-33553 (2008)
   PUBMED   18829453
REFERENCE   9  (bases 1 to 3858)
  AUTHORS   Shirakabe,K., Priori,G., Yamada,H., Ando,H., Horita,S., Fujita,T.,
            Fujimoto,I., Mizutani,A., Seki,G. and Mikoshiba,K.
  TITLE     IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein,
            specifically binds to and activates pancreas-type Na+/HCO3-
            cotransporter 1 (pNBC1)
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9542-9547 (2006)
   PUBMED   16769890
REFERENCE   10 (bases 1 to 3858)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_008761405.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.773629.1,
                                           SRR26360176.321956.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               JAXUCZ010000002.1  198016366-198016772 c
            408-519             JAXUCZ010000002.1  197996976-197997087 c
            520-663             JAXUCZ010000002.1  197994562-197994705 c
            664-764             JAXUCZ010000002.1  197993582-197993682 c
            765-867             JAXUCZ010000002.1  197993022-197993124 c
            868-962             JAXUCZ010000002.1  197991814-197991908 c
            963-1069            JAXUCZ010000002.1  197990910-197991016 c
            1070-1186           JAXUCZ010000002.1  197989966-197990082 c
            1187-1250           JAXUCZ010000002.1  197989657-197989720 c
            1251-1339           JAXUCZ010000002.1  197988861-197988949 c
            1340-1410           JAXUCZ010000002.1  197988425-197988495 c
            1411-1505           JAXUCZ010000002.1  197987990-197988084 c
            1506-1604           JAXUCZ010000002.1  197987807-197987905 c
            1605-1673           JAXUCZ010000002.1  197987176-197987244 c
            1674-1752           JAXUCZ010000002.1  197986588-197986666 c
            1753-1873           JAXUCZ010000002.1  197984726-197984846 c
            1874-3858           JAXUCZ010000002.1  197982335-197984319 c
FEATURES             Location/Qualifiers
     source          1..3858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3858
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="adenosylhomocysteinase-like 1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
     exon            1..407
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1880
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /EC_number="3.13.2.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     S-adenosylhomocysteine hydrolase-like 1; putative
                     adenosylhomocysteinase 2; adoHcyase 2;
                     S-adenosyl-L-homocysteine hydrolase 2;
                     S-adenosylhomocysteine hydrolase-like protein 1;
                     IP3R-binding protein released with inositol
                     1,4,5-trisphosphate"
                     /codon_start=1
                     /product="S-adenosylhomocysteine hydrolase-like protein 1
                     isoform 2"
                     /protein_id="NP_001424847.1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
                     /translation="MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQF
                     ADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGS
                     SNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAV
                     LIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNM
                     DGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAM
                     NVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALG
                     AIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSC
                     IVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCSTV
                     PTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT
                     DDQAKYLGLNKNGPFKPNYYRY"
     misc_feature    603..1874
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    603..1874
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    order(630..632,639..641,651..653,660..665,1065..1067,
                     1074..1079,1125..1127,1131..1133,1143..1148,1158..1160,
                     1167..1172,1182..1184,1191..1196,1203..1223,1245..1250,
                     1257..1259,1284..1289,1293..1295,1308..1334,1338..1349,
                     1353..1364,1371..1373,1410..1424,1452..1460,1491..1493,
                     1542..1547,1560..1562,1632..1634,1638..1640,1644..1649,
                     1656..1658,1734..1736,1752..1757,1764..1769,1776..1778,
                     1785..1790,1794..1802,1806..1808,1815..1820,1827..1832)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    order(630..632,639..641,651..653,660..665,1065..1067,
                     1074..1079,1125..1127,1131..1133,1143..1148,1158..1160,
                     1167..1172,1182..1184,1191..1196,1203..1223,1245..1250,
                     1257..1259,1284..1289,1293..1295,1308..1334,1338..1349,
                     1353..1364,1371..1373,1410..1424,1452..1460,1491..1493,
                     1542..1547,1560..1562,1632..1634,1638..1640,1644..1649,
                     1656..1658,1734..1736,1752..1757,1764..1769,1776..1778,
                     1785..1790,1794..1802,1806..1808,1815..1820,1827..1832)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    order(744..746,750..752,756..761,972..974,1047..1052,
                     1137..1139,1149..1151,1620..1622,1635..1637,1650..1652,
                     1662..1664)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(744..746,750..752,756..761,972..974,1047..1052,
                     1137..1139,1149..1151,1620..1622,1635..1637,1650..1652,
                     1662..1664)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(1050..1058,1152..1154,1164..1166,1239..1241,
                     1245..1253,1305..1316,1323..1325,1404..1415,1422..1424,
                     1476..1484,1611..1613,1617..1619,1635..1637)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(1050..1058,1152..1154,1164..1166,1239..1241,
                     1245..1253,1305..1316,1323..1325,1404..1415,1422..1424,
                     1476..1484,1611..1613,1617..1619,1635..1637)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     exon            408..519
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            520..663
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            664..764
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            765..867
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            868..962
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1069
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1186
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1250
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1339
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1410
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1505
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1604
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1673
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1752
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1873
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3858
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttgcgtg cgtgcttgcg tgtggcggag gtggctgcgc gggcaggtcg gagctgcgtg
       61 ctgttgcttc tggttcttct gtggccgccg tcgctgtccg gcaggcttgg gttgagaagc
      121 cgacaaggcg cgcgggtcac agcccttcgg aagcccaagg agctcggcgc ggggcctggc
      181 gggaaggcgg gcgagcgcgt ggcccagggc gccgcgcgga cgggcgggcg cccgtgaggg
      241 gaagaggcgg gggcggcggg ttagccgcgg gccgggccgg ccgggggatg tcgatgcctg
      301 acgcgatgcc gctgcccggt gtcggggagg agctgaaaca ggccaaggag atcgaggacg
      361 ccgagaagta ctccttcatg gccacggtca ccaaggctcc caagaagcaa atccagtttg
      421 cggatgacat gcaagagttc accaaattcc ctactaagac tggccggaga tccttgtctc
      481 gctccatctc acagtcctcc acagacagct acagttcagc tgcatcctat acagatagct
      541 ctgatgatga ggtttccccc cgagagaagc agcaaaccaa ctcaaagggc agcagcaatt
      601 tctgtgtgaa gaacatcaag caggcagagt ttggacgccg ggagattgag attgcagagc
      661 aagacatgtc tgctctgatt tcactcagga aacgtgctca gggagagaag cctttggctg
      721 gtgctaaaat agtgggctgt acacacatca cagcccagac agcggtattg attgagacac
      781 tttgtgccct gggggctcag tgccgctggt ctgcctgcaa catctattca actcagaatg
      841 aggtagctgc agcactggct gaggctggag ttgcagtgtt tgcttggaag ggcgagtcag
      901 aagatgattt ctggtggtgc attgaccgct gtgtcaacat ggatgggtgg caggctaaca
      961 tgatcctgga tgatggggga gacttaaccc actgggttta taagaagtat ccaaacgtgt
     1021 ttaagaagat ccgaggcatt gtggaagaga gcgtgactgg tgttcacagg ctgtatcagc
     1081 tctccaaagc tgggaagctc tgtgttccag ccatgaatgt caatgattct gttaccaaac
     1141 agaagtttga taacttgtac tgctgccgag aatccatttt ggatggcctg aagaggacca
     1201 cagatgtgat gtttggtggg aaacaggtgg tggtgtgtgg ctatggtgag gtaggaaagg
     1261 gctgctgtgc tgctctcaag gcccttggag caattgtcta catcacagaa attgacccca
     1321 tctgtgctct gcaggcctgc atggatgggt tccgggtggt gaagctgaat gaagtcatcc
     1381 ggcaggtgga cgttgtaata acttgcacag gaaataagaa tgtagtgacc cgggagcact
     1441 tggaccgaat gaaaaatagt tgcattgtat gtaatatggg ccattccaac acagaaattg
     1501 atgtgaccag cctccgcact ccagagctaa catgggagcg cgtacgttct caggtggacc
     1561 atgtcatctg gcctgatggc aagcgggtcg tccttctagc agagggtcgt ttactcaatt
     1621 tgagctgctc cacagttcct acctttgtcc tttccatcac ggctacaaca caggctttgg
     1681 cactgataga actttataat gcaccagaag gacgctacaa acaggatgtg tacttgcttc
     1741 ctaagaaaat ggatgagtat gttgccagct tgcacctgcc atcatttgat gcccacctca
     1801 cagagctgac agatgaccaa gcaaaatatc tgggactcaa caaaaatggg ccattcaaac
     1861 ctaattatta cagatactaa tggacgtatt acaatgacca gtccacacga accacgcaac
     1921 tctaatagag tattttttaa gataactttt attttcttct tattactttc cttttgattt
     1981 ttttttctat aatttcattt tttttctcat ctcatcattt gagttttgca gaccacacag
     2041 gaacttgctc catggctgtt taggtgaaac tgaggtcaaa ggtttctcac ctttagtcac
     2101 taaaaggggt taattctgca gcccagaaag tcaattcttt aaccatttct ggggactttg
     2161 atcgcattta gttaccatat taacagaaaa tgctaaggca tcttctgtgt ggaacaatct
     2221 acagtgtcta aattgcctta aaagagactg ttctagctgc tggaactagt gctctttact
     2281 tcttcagagg agccaggatg gctccagcca ggtaggttag acgtaggtgg tgcatgtcaa
     2341 cttcccgtag acagacgctc taagccgttt cctgtctaag atggcgtgtc tgcagagatg
     2401 tgtgctgtta aactccgtag gctcactcgg atttgtagtt cagcccttcc accagtctct
     2461 ctcattgttc tagttttaac taaactgcat tctatcaagt tgaattttgt cccttagcat
     2521 ttatttgttt tgtttctttt aattaaggaa aaattttagt gttaatcctg aggaacagct
     2581 caggtggtta gttaccaata tctcttttga acctttgaag caaagtgtca agagttgagg
     2641 ctagaaaaat gctagcctca gactctgatg tttccagctc atagtttata gtgtcagtga
     2701 actggagcca taagcaaaac ttctcagctc tgcctcacgc agcttatgct gacggccgat
     2761 ttcttgagcc attactcagt ataaaacact gagccctgtc cttagggttt atcctttcag
     2821 agcaaacctg tgggcagctg tgcttctgca acctaaactg tttgaaggga agtttgcata
     2881 gatggaagaa agaatgacaa attgggccaa ggtgaaacaa atataactgt ataatctgtt
     2941 cagagctgga gaccttgtct gctgttagtt ttatagacat ggtgccactt ttgattgaca
     3001 cttgccacaa aaatagaaaa taaaaattgt aaactgagat cttaaagact tggtggagaa
     3061 agtacatcct gattcatgct ctaagagaat tccaagagac cctctaaaat cagagagact
     3121 tattcccagg ccacgcaccc gcttgccagc atctctgcat ggtcaaacga gcttcaagct
     3181 caagctttag gtatataatt atccgggatt ttaagtcctc agcgtgttct agcttgtgat
     3241 ccttcaaaga tgggttatgt gttaatgata gatactggaa atgtttactt ctctctttca
     3301 ctgatcagag aaacaggcat taaaaacaga aatacaagaa aggaaagctt ttaccctgca
     3361 ccttccttgc agggaacaat tatcttgcca aaactttttt ccctttcatc tcccatttct
     3421 ctgtacccag ccccttcctg ctcctttcca atgtgatcat gctttcttct ctatagatac
     3481 taacatttga agaccccttt cctaaggcac ttaaccatcc aatcagaaca ccacactcag
     3541 tagggcctta tcttggctaa cagcagtgta ttcatctggt cagctctact ggagggaagg
     3601 ggccaagttc ctgctgccct ctaatctgcc ctctggtcct atctattact gtgtccatag
     3661 gaataatagg taagggctag tctctgtcaa gccatgtaac aaaggacact ggaaaatgtc
     3721 tggcatcaga gggaacattt ggagaccaac ttgggaggaa aatattcatt ttgtattgaa
     3781 tgatttttaa tgaatgcaat attaatcctt gcagatgagc aataatcatt aaagtcaatt
     3841 aaaagtgata agacataa
//
LOCUS       NM_001437943            7627 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus dedicator of cytokinesis 9 (Dock9), transcript
            variant 1, mRNA.
ACCESSION   NM_001437943 XM_063274019
VERSION     NM_001437943.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7627)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   2  (bases 1 to 7627)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7627)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 7627)
  AUTHORS   Nishikimi,A., Meller,N., Uekawa,N., Isobe,K., Schwartz,M.A. and
            Maruyama,M.
  TITLE     Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide
            exchange factor expressed predominantly in lymphocytes
  JOURNAL   FEBS Lett 579 (5), 1039-1046 (2005)
   PUBMED   15710388
REFERENCE   5  (bases 1 to 7627)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063274019.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1847360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000015.1  105199266-105199522 c
            258-374             JAXUCZ010000015.1  105182942-105183058 c
            375-464             JAXUCZ010000015.1  105168842-105168931 c
            465-547             JAXUCZ010000015.1  105162379-105162461 c
            548-617             JAXUCZ010000015.1  105160417-105160486 c
            618-713             JAXUCZ010000015.1  105158803-105158898 c
            714-848             JAXUCZ010000015.1  105157736-105157870 c
            849-1023            JAXUCZ010000015.1  105151440-105151614 c
            1024-1091           JAXUCZ010000015.1  105149491-105149558 c
            1092-1166           JAXUCZ010000015.1  105137132-105137206 c
            1167-1307           JAXUCZ010000015.1  105135597-105135737 c
            1308-1505           JAXUCZ010000015.1  105134347-105134544 c
            1506-1628           JAXUCZ010000015.1  105133869-105133991 c
            1629-1711           JAXUCZ010000015.1  105129765-105129847 c
            1712-1834           JAXUCZ010000015.1  105129126-105129248 c
            1835-1914           JAXUCZ010000015.1  105124162-105124241 c
            1915-2102           JAXUCZ010000015.1  105123885-105124072 c
            2103-2168           JAXUCZ010000015.1  105123662-105123727 c
            2169-2261           JAXUCZ010000015.1  105122343-105122435 c
            2262-2385           JAXUCZ010000015.1  105120141-105120264 c
            2386-2507           JAXUCZ010000015.1  105119666-105119787 c
            2508-2594           JAXUCZ010000015.1  105118736-105118822 c
            2595-2684           JAXUCZ010000015.1  105117931-105118020 c
            2685-2800           JAXUCZ010000015.1  105115724-105115839 c
            2801-2870           JAXUCZ010000015.1  105113993-105114062 c
            2871-2996           JAXUCZ010000015.1  105113031-105113156 c
            2997-3068           JAXUCZ010000015.1  105111200-105111271 c
            3069-3215           JAXUCZ010000015.1  105101578-105101724 c
            3216-3299           JAXUCZ010000015.1  105101310-105101393 c
            3300-3411           JAXUCZ010000015.1  105100567-105100678 c
            3412-3590           JAXUCZ010000015.1  105098660-105098838 c
            3591-3704           JAXUCZ010000015.1  105098365-105098478 c
            3705-3822           JAXUCZ010000015.1  105096851-105096968 c
            3823-3956           JAXUCZ010000015.1  105091621-105091754 c
            3957-4068           JAXUCZ010000015.1  105089536-105089647 c
            4069-4135           JAXUCZ010000015.1  105087183-105087249 c
            4136-4183           JAXUCZ010000015.1  105085955-105086002 c
            4184-4320           JAXUCZ010000015.1  105083443-105083579 c
            4321-4436           JAXUCZ010000015.1  105076918-105077033 c
            4437-4574           JAXUCZ010000015.1  105074536-105074673 c
            4575-4757           JAXUCZ010000015.1  105074236-105074418 c
            4758-4871           JAXUCZ010000015.1  105072671-105072784 c
            4872-5087           JAXUCZ010000015.1  105072316-105072531 c
            5088-5145           JAXUCZ010000015.1  105069893-105069950 c
            5146-5252           JAXUCZ010000015.1  105067917-105068023 c
            5253-5375           JAXUCZ010000015.1  105053003-105053125 c
            5376-5489           JAXUCZ010000015.1  105051698-105051811 c
            5490-5525           JAXUCZ010000015.1  105051037-105051072 c
            5526-5672           JAXUCZ010000015.1  105050156-105050302 c
            5673-5883           JAXUCZ010000015.1  105046980-105047190 c
            5884-6074           JAXUCZ010000015.1  105035414-105035604 c
            6075-6175           JAXUCZ010000015.1  105031777-105031877 c
            6176-6314           JAXUCZ010000015.1  105031234-105031372 c
            6315-7627           JAXUCZ010000015.1  105026789-105028101 c
FEATURES             Location/Qualifiers
     source          1..7627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24-q25"
     gene            1..7627
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="dedicator of cytokinesis 9"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
     exon            1..257
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    117..119
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="upstream in-frame stop codon"
     CDS             138..6437
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dedicator of cytokinesis protein 9; cdc42 guanine
                     nucleotide exchange factor zizimin-1; Thyroid regulating"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 9 isoform 1"
                     /protein_id="NP_001424872.1"
                     /db_xref="GeneID:259237"
                     /db_xref="RGD:629617"
                     /translation="MQADKYRTSGRNDKKELVIESPLQYKDAAQADSEAENSALAKPK
                     LIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYVRSTVPANAEEEA
                     QSLFVTECIKTYNSDWHLVTYHYEDYSGEFRQLPNKVAKLDKLPVHVYEVDEEADKDE
                     DAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEK
                     ISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKI
                     LQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVK
                     LFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVE
                     PFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPASPVLMNGGQSPPAFQDALQAA
                     MQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQ
                     ACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNEDMLKLLADFRK
                     PEKMAKLPVILGNLDITIDNVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCI
                     PKHTQPYTVYSNHLYVYPKYLRYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGR
                     PGGPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGST
                     KKKDAVETQVGFSWLPLLKDGRVLTNEQHIPVSANLPSGYLGYQELSMGRHYGPEVKW
                     VEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEG
                     HVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAY
                     KAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE
                     NNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFT
                     FMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQ
                     RYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDD
                     RYTSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSISKDEALAVPTGNPL
                     MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPD
                     RNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKA
                     STAELMDFFTISEVCLHQFQYMGKRYIARSQEGLGPIGHDRKSQTLPVSRNRAGMAHA
                     RLQQLGSLDNSVTFNHSYGHSEADVAHQSLLEANIATEVCLTALDTLSLFTLAFKNQL
                     LADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSTFYEGRADMCAS
                     LCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADV
                     VGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDP
                     EMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTR
                     KGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYE
                     LIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQ
                     QYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQD
                     SGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCHNIRRFMFEMPFTQTGKR
                     QGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLC
                     SSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFV
                     EACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSL
                     HIFNAISGTPTSTVVQGLTSSSSVV"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    264..596
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis C/D, N terminal; Region:
                     DOCK_C-D_N; pfam11878"
                     /db_xref="CDD:463380"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    636..1007
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; Region: PH_DOCK-D; cd13267"
                     /db_xref="CDD:270087"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    2037..2606
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-D; cd08697"
                     /db_xref="CDD:176079"
     misc_feature    5022..6302
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    5022..6302
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; Region: DHR2_DOCK9; cd11698"
                     /db_xref="CDD:212571"
     misc_feature    order(5334..5336,5364..5366,5370..5375,5379..5384,
                     5391..5396,5400..5405,5412..5417)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5334..5336,5364..5366,5370..5375,5379..5384,
                     5391..5396,5400..5405,5412..5417)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212571"
     misc_feature    order(5436..5447,5451..5453,5574..5579,5583..5594,
                     5598..5603,5658..5666,5715..5717,5721..5723,5808..5810,
                     5814..5816,5835..5840,5856..5858,5973..5978,5985..5987,
                     6027..6029,6033..6035,6045..6047,6054..6062,6069..6080,
                     6084..6089,6096..6098,6180..6182,6234..6239,6243..6248,
                     6255..6257)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    order(5436..5447,5451..5453,5574..5579,5583..5594,
                     5598..5603,5658..5666,5715..5717,5721..5723,5808..5810,
                     5814..5816,5835..5840,5856..5858,5973..5978,5985..5987,
                     6027..6029,6033..6035,6045..6047,6054..6062,6069..6080,
                     6084..6089,6096..6098,6180..6182,6234..6239,6243..6248,
                     6255..6257)
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212571"
     misc_feature    6069..6086
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     misc_feature    6069..6086
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212571"
     exon            258..374
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            375..464
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..547
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            618..713
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1023
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1091
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1505
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1628
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1711
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1834
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1914
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2102
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2168
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2385
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2507
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2684
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2800
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2870
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2996
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3215
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3299
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3411
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3590
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3704
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3822
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3956
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4068
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4135
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4183
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4320
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4436
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4574
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4757
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4871
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            4872..5087
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5145
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5252
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5375
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5489
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5490..5525
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5672
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5673..5883
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..6074
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6075..6175
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6176..6314
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
     exon            6315..7627
                     /gene="Dock9"
                     /gene_synonym="Trg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccaccc ctgaggctcc gcacttccag ccttgtgcct gggaaacagg cttccttgcc
       61 tttctctggc cagtggtgca gcaggggact ctcagctgtc cctgctgcag gctttctgac
      121 agtggtctgg gtggagaatg caggctgata agtacaggac tagcggtaga aatgacaaga
      181 aggagctggt catcgagtct cccctgcagt acaaggatgc agctcaggca gactcggagg
      241 cagagaactc ggcattggca aagccaaagc tgattgagcc acttgactac gaaaatgtca
      301 tcgtgcagaa gaagacccag atcctgaatg actgtctgcg ggagatgctc ctcttccctt
      361 acgatgactt ccagacggcc atcctgaggc ggcaggggcg ctacgtacgt tccacggtcc
      421 ctgcaaatgc agaggaggaa gcacagagcc tgtttgtcac cgagtgcatc aaaacctaca
      481 actctgactg gcaccttgtg acctatcact atgaagatta ctcaggagag ttccgacagc
      541 ttccaaacaa agtggccaag ttggataaac ttccagttca cgtctatgaa gtcgatgagg
      601 aggctgacaa agatgaggac gctgcttccc ttgggtctca gaagggtgga atcacaaagc
      661 acggctggct gtacaaaggc aacatgaaca gtgccatcag cgtgaccatg aggtcattca
      721 agaggcggtt tttccacctg attcagcttg gcgatggatc ctataatcta aacttttata
      781 aagatgagaa gatctccaag gagccgaaag ggtccatatt cctggattcc tgcatgggcg
      841 tgatccagaa caacagagtc aggcgcttcg cctttgagct caagatgcag gacaaaagca
      901 gttaccttct ggctgcggac agtgaggcag agatggagga gtgggtcaca gtcctcaaca
      961 agatcctcca gctcaacttt gaggctgcaa tgcaagagaa gcgaaatggg gaccctcatg
     1021 aagatgatga acaaagcaaa ctggaaggtt ccggttccgg tttggacagc tacctgcctg
     1081 aacttgccaa gagcaccaga gaagcagaaa tcaaactgaa aagcgagagc agagtgaagc
     1141 tcttttactt ggacccagat acccagaaac tcgacttctc atctgctgaa ccagaagtga
     1201 agccatttga agaaaagttt gggaagagga ttctcgtcaa gtgcaatgat ttgtccttca
     1261 acctgcagtg ctgtgtcgca gagaacgagg aaggacccac gacaaatgtg gagcctttct
     1321 ttgtcaccct gtccctgttc gacataaaat acaaccggaa gatttctgct gacttccacg
     1381 tggacctgaa ccacttctca gtgcggcaga tgctggcccc tgcatcccca gtgctgatga
     1441 acggtggtca gagtccacct gccttccagg atgcccttca ggcggccatg cagtatccga
     1501 agcagggaat attttcagtc acgtgtcctc acccagacat atttcttgtg gccagaattg
     1561 aaaaggtcct ccaaggaagc atcacgcact gtgctgagcc ttacatgaaa agctcagact
     1621 cttctaaggt cgctcagaag gtgctgaaga atgccaagca ggcatgtcaa agactaggac
     1681 agtaccgaat gccgtttgct tgggcagcaa ggacgttgtt taaagacaca tctggaaacc
     1741 tggataaaaa tgccaggttt tctgccatct accggcaaga cagcaataag ctctcaaatg
     1801 aggacatgct caagctgctc gcagacttcc ggaaacctga gaagatggcc aaactcccag
     1861 tgattttagg caatctagac attacaatcg acaacgtttc ctgcgacttc cctaattacc
     1921 tgaattcatc atacattccc atgaggcagt ttgaaacctg cagtaagtct ccgatcacct
     1981 tcgaagtaga ggagtttgtg ccctgcatac ccaagcacac ccagccttat acagtctaca
     2041 gcaatcacct ttatgtttac cccaagtact tgagatacga cagccagaag tcttttgcca
     2101 aggccagaaa cattgcaatc tgcattgagt tcaaggattc cgatgaagaa gactcgcaac
     2161 ccttgaagtg catttacggc agacctggtg gcccagtgtt cacaaggagt gccctcgctg
     2221 cagtcctaca ccatcaacaa agcccagaat tctacgatga gatcaagata gagctgcccg
     2281 cccagctgca cgagaagcac catttactgt tcaccttctt ccacgtcagc tgcgacaact
     2341 cgaccaaagg gagcacgaag aagaaggacg ctgtggagac acaggttggc ttctcctggc
     2401 ttcctctcct gaaagacggc agagtgttga cgaatgaaca gcatatccct gtctccgcca
     2461 acctgccgtc tggctacctt ggctaccagg agctcagcat gggcaggcat tatggtccag
     2521 aagttaagtg ggtggaagga ggcaagccat tgttgaaaat ctccactcat ctggtttcca
     2581 ccgtgtacac tcaggatcag cacttacaca attttttcca atactgtcag aaaacggaat
     2641 ctggagccca agcctcaggg agtgaactag tgaaatacct taagagtctg catgcaatgg
     2701 aaggtcacgt gatgatcgcc ttcctgccga ccattttaaa ccagctattc cgagtcctca
     2761 ccagagccac ccaggaggag gttgcagtta atgtgactcg ggtcattatt catgtggttg
     2821 cccagtgcca tgaggaagga ttggagagcc acttgaggtc atatgttaag tttgcctaca
     2881 aggctgagcc gtatatagca tccgagtata agacagtgca cgaggaactg acgaaatcca
     2941 tgaccaccat tctcaagcct tctgctgatt tccttaccag caacaaactt ctgaagtact
     3001 cttggttttt ctttgatgtg ctgataaagt ccatggctca gcatttgatt gaaaataaca
     3061 aagtgaagtt acttcgaaac cagagatttc cggcctccta ccatcacgcc gtggaaaccg
     3121 tggtgaacat gctgatgccg cacatcacac agaagtttcg agataaccca gaagcatcta
     3181 agaatgccaa tcacagcctg gccgtgttca tcaagagatg cttcaccttc atggacagag
     3241 gcttcgtctt caaacagatc aacaactaca tcagttgctt tgctcctgga gaccccaaga
     3301 ctctctttga gtacaagttt gagtttctcc gtgtggtgtg caaccatgaa cactatattc
     3361 ctttgaactt gccgatgcca tttgggaaag gaagaattca gagataccaa gatctccagc
     3421 ttgactactc tttaacggac gaattctgca gaaaccactt cttggtggga ctgttactaa
     3481 gggaggtggg tactgcactc caggagttcc gggaggtccg tgtcatcgct gtcagtgtgc
     3541 tcaagaacct tctgatcaag cattcttttg atgacagata cacttcaagg agtcaccagg
     3601 caaggatagc caccctctac ctgcctctgt ttggtctgct tattgaaaac gtccagcgga
     3661 tcaacgtgag ggatgtgtcg cccttccctg tgaacccggg cagtatctcg aaggacgaag
     3721 ccctggccgt gcctaccggg aatccactca tgactccgca gaagggaaac acacttgacc
     3781 acagcctgca caaagacctc ttgggtgcca tctccggcat tgcttctccg tatacagctt
     3841 caacccccaa catcaacagt gtgagaaatg ccgactcaag gggctctctc atcagcacgg
     3901 actcggggaa cagccttcca gacaggaacc ccgagaagag caactccctg gacaagcagc
     3961 agagcggcat gctgggaaat tctgtggtcc gctgtgacaa actggaccag tctgagatca
     4021 agagcctgct gatgtgcttc ctctacgtgt tgaagagcat gtctgacgat gccctgttta
     4081 cgtactggaa caaggcttcc actgctgaac tgatggattt ctttaccata tctgaagtgt
     4141 gcctgcacca gttccagtac atggggaagc gctacatagc caggagccag gaggggttgg
     4201 gacccatagg tcacgaccga aagtctcaga cactgcctgt ttcccgtaac agagcaggga
     4261 tggcgcatgc cagattgcag cagctgggca gcctggataa ctctgtcact tttaaccaca
     4321 gctacggcca ctcggaggca gatgtcgctc accagtcgct tctcgaagca aacatcgcca
     4381 ctgaggtctg cctcacagct ctggacaccc tctcgctgtt cacactggct tttaagaacc
     4441 agctcctagc tgaccatgga cataatccac tcatgaagaa agtttttgat gtctacctgt
     4501 gtttcctcca aaagcatcag tcagaaatgg ctttaaaaaa tgtcttcact gccttaaggt
     4561 cattaattta taagttcccc tcaacgttct acgaggggcg ggcagacatg tgcgcatctc
     4621 tgtgctatga ggttctcaag tgctgtaact ccaagctcag ctccatccgc accgaggcct
     4681 cccagctgct ctacttcctg atgaggaaca acttcgacta cacagggaag aagtcttttg
     4741 tccggacaca cttacaggtc atcatctctg tcagccagct gatcgcagac gtggttggca
     4801 ttggaggaac cagattccag cagtccttgt ctatcatcaa caactgtgcc aatagcgacc
     4861 ggctcattaa gcacaccagc ttctcctctg atgtgaagga tttgaccaag aggatccgca
     4921 cagtcctgat ggccacagcc cagatgaagg aacatgagaa cgacccagag atgctggtgg
     4981 acctgcagta cagcctggcc aagtcctacg ccagcacccc tgagctcagg aagacatggc
     5041 tggacagcat ggcaaggatc catgttaaaa atggggatct ctcagaggca gcaatgtgct
     5101 atgtccacgt gacagctttg gtagcggaat atctcacacg gaaaggcatg ttcagacagg
     5161 ggtgcacagc cttcagggtc atcacaccaa acattgatga agaggcttcc atgatggaag
     5221 atgtcggcat gcaggatgtc catttcaatg aggatgtgct gatggagctg ctggagcagt
     5281 gcgcagatgg actttggaag gcagagcgct acgagctgat tgctgacatc tataaactca
     5341 tcatccccat ctatgaaaag cggagggact ttgagagact agcccacctg tatgacacgc
     5401 tgcaccgcgc atacagcaaa gtgacagagg tcatgcactc gggccgcagg ctcctgggga
     5461 cctacttccg ggtggccttc ttcggacagc aataccagtt tacagacagt gaaacagatg
     5521 tggagggatt cttcgaagat gaagacggga aggaatacat ctacaaagag cccaaactca
     5581 cgcctctgtc agagatttct cagagactcc ttaaacttta ctcggataaa ttcggttctg
     5641 aaaatgtcaa aatgatacag gattctggca aggtcaaccc gaaggatctg gattccaagt
     5701 ttgcttacat ccaggtgacc catgtgaccc cgttctttga tgaaaaggag ttacaggaga
     5761 ggaaaacaga gtttgaacga tgtcacaaca tccggcgctt catgttcgag atgcccttca
     5821 cccagactgg gaagaggcag ggtggcgtgg aggagcagtg taagcgacgg accatcctga
     5881 cagcaataca ctgcttcccc tatgtaaaga agcggatccc tgtcatgtac cagcaccaca
     5941 ctgacctgaa ccccattgag gtggccatcg atgaaatgag caagaaagtg gccgagctcc
     6001 gccagctgtg ttcctcagct gaagtggaca tgatcaaact gcagctcaaa ctgcagggca
     6061 gtgtgagcgt ccaggtcaat gctggcccgc tagcatacgc ccgagccttc ctcgatgaca
     6121 ccaacacaaa gagataccct gacaataagg tgaagctgct gaaggaagtt ttcaggcaat
     6181 tcgtggaagc ttgtggccaa gccttggcag tgaacgaacg tctgattaaa gaggaccagc
     6241 tggagtacca ggaagagatg aaagccaact acagggagat ggccaaggag ctctccgaca
     6301 tcatgcgtga gcaaatttgc cccctggagg agaagacaag cgtgctacca aattccctgc
     6361 acatcttcaa cgccatcagt gggacaccaa caagcacagt ggttcaaggg ttgaccagtt
     6421 catcctcagt tgtgtgactt tacctcatga accacacgtg gggacatgct ttgtcatgtg
     6481 caaactcagg acgactttca gagctaatca ctggttttgc caagcacagg aagaagccat
     6541 ggggaatggg agagagaaag agcctggact gtgatattta atagcagatt ttataggagt
     6601 tgggggaagg tgcacatatt tttttaaata tcactggcaa tgtttagttt tcctcatgtc
     6661 ttaacaggtg tatgtggata ctcttgggct gcagttcaat tttattcttc ttacagtata
     6721 gtattaaaat aaatggtcta aaggaaaaga gggaaagtat gctgggacac ctgtagcagg
     6781 tgtgctggga cacctgtacc agctgtgctg ggacacctgt accagctgtg ctgggacacc
     6841 tgtagcagat gcagcagcac tgaacctggg aatggggact aagctggaaa aatcttgaaa
     6901 atatttttct ccctgtggca cattcaggtt gagtacaaga actatttttg tgtctagttt
     6961 tgaagactga agggaattga ctattgagat tttttactag tgaatgcgga gacttagagc
     7021 ctttatatcc atgccttgtg ttgacaacat gagcacttcc gaagctgagt gtgatgtgag
     7081 cctaagccta gtcagcagca tagaaccaaa ggcctgcact agcgaacaca cctatgctaa
     7141 aacctaaaac cccatgtaca tatgttctgt taatacggcc tcctcgctga gtccacgtac
     7201 ttactacatt tctacacttt taatacatca gtgtccgtgt taagtttatt attcgtgacc
     7261 catttgtgct gttctcggta tatgcaaata cattggactt cactgtttat tcttgtacat
     7321 aagaagtgca atatggagat gtatacagtc tttgctatgt taggtttata aactgttttt
     7381 aaaaagaaat tcatcctttt gccaaaatgg tggagtatgt gattggtaaa ccctaaaccc
     7441 tgtggtgagt ggagggataa tttaaagttt tcaccatgtt atattttctt ttaagacttt
     7501 aatttagtaa ttttatattt gggaaaataa aggtttttaa tttaactgga atcactgccc
     7561 tgctgtaatt acatatcgtg taccccaact gtattaaaaa taacactgct gattttctgg
     7621 taataaa
//
LOCUS       NM_001012232             750 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus ribonuclease 17 (Rnase17), mRNA.
ACCESSION   NM_001012232 XM_008770561
VERSION     NM_001012232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_008770561.3, NM_001012232.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1662139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000015.1  26973497-26973596   c
            101-750             JAXUCZ010000015.1  26972687-26973336   c
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..750
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="ribonuclease 17"
                     /db_xref="GeneID:497195"
                     /db_xref="RGD:1359245"
     exon            1..100
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /inference="alignment:Splign:2.1.0"
     exon            101..750
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..573
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="ribonuclease 1"
                     /codon_start=1
                     /product="ribonuclease 17 precursor"
                     /protein_id="NP_001012232.1"
                     /db_xref="GeneID:497195"
                     /db_xref="RGD:1359245"
                     /translation="MGLKLLESRLCLLLLLGLVLMLASCQPPTPSQWFEIQHIYNRAY
                     PRCNDAMRHRNRFTRHCKDKNTFLHTSFASVVGVCGNRNIPCRNRRYRNCHNSPYRVS
                     ITFCNLTTPARIYTQCRYQTTRSRKFYTVGCDPRTPRDSPMYPVVPVHLDRIF"
     sig_peptide     106..180
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    190..570
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="Pancreatic ribonuclease; Region: RNAse_Pc;
                     smart00092"
                     /db_xref="CDD:128403"
     misc_feature    190..570
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="Pancreatic ribonuclease; Region: RNAse_Pc;
                     smart00092"
                     /db_xref="CDD:128403"
     misc_feature    order(205..234,241..243,253..255,259..267,289..291,
                     298..315,415..417,475..477,547..549)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="dimerization with domain swap [active]"
                     /db_xref="CDD:119387"
     misc_feature    order(205..234,241..243,253..255,259..267,289..291,
                     298..315,415..417,475..477,547..549)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="dimerization with domain swap [active]"
                     /db_xref="CDD:119387"
     misc_feature    order(217..219,289..291,301..303,382..384,418..420,
                     553..558)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="catalytic site [active]"
                     /db_xref="CDD:119387"
     misc_feature    order(217..219,289..291,301..303,382..384,418..420,
                     553..558)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="catalytic site [active]"
                     /db_xref="CDD:119387"
     misc_feature    order(292..294,391..393,424..426,472..474,478..480,
                     484..489,493..495)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:119387"
     misc_feature    order(292..294,391..393,424..426,472..474,478..480,
                     484..489,493..495)
                     /gene="Rnase17"
                     /gene_synonym="R1; R17"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:119387"
ORIGIN      
        1 ggactgctcc atatctgtgg acccaagtgg agctcagcca ttacccgtga tttccaggac
       61 agccagcact cagttccaca ggagccgcaa cgcacactag gaaacatggg tctgaagctg
      121 ctcgagtcca gactttgtct ccttctgctg ctgggacttg tcctgatgct tgcctcatgc
      181 cagccaccaa ccccttccca gtggtttgaa atccagcaca tctataatag ggcttatcca
      241 cgatgtaatg atgcaatgcg acacagaaac agattcacca gacattgtaa ggacaaaaat
      301 actttccttc atacaagttt tgctagtgtt gttggtgtgt gtggcaatag aaacatcccc
      361 tgtagaaaca ggagatatag aaattgtcat aacagtccat atcgggtatc tataactttc
      421 tgtaacctca caactccggc aaggatttat acccaatgta gataccaaac tacaagatcc
      481 aggaagttct acacagttgg ctgtgacccg aggactccac gggacagtcc catgtatcca
      541 gtggttccgg ttcacttgga taggatattt tagctccggt gccagcactt tgtacctgag
      601 ctcatctgct tctgccaaga tcatagtagt gaagatccag ttcctctgtc tgccctgcgt
      661 atcagctcct gtcctcatga aaccttaccc tgactccctt taatatagct taacagattt
      721 ttgtaatcaa taaacacctt tgcatatgca
//
LOCUS       NM_001437951            1116 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus golgin A6 family like 9 (Golga6l9), transcript
            variant 1, mRNA.
ACCESSION   NM_001437951 XM_006252385
VERSION     NM_001437951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006252385.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.876738.1,
                                           SRR26360186.2255443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000015.1  78875208-78875245
            39-1116             JAXUCZ010000015.1  78875664-78876741
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..1116
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="golgin A6 family like 9"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
     exon            1..38
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     exon            39..1116
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    95..97
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="upstream in-frame stop codon"
     CDS             149..973
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="spermatid associated like"
                     /codon_start=1
                     /product="uncharacterized protein LOC290425"
                     /protein_id="NP_001424880.1"
                     /db_xref="GeneID:290425"
                     /db_xref="RGD:1306441"
                     /translation="MNISGSKQIHKRKILRLFSCFSCTQNQKKLKHKSQDVEKKLCRE
                     NKVLRDENRALRKDNKFLWGENKALGRENKTFRMDNQFIRERNHILRQQNQLLRKVKR
                     LISENPKLSGEECNALNTEGRSFWQQNRAMEAQITALRQQEKAFQNEAKALHEEIKSL
                     CEETKALQHQERALRMEEKALLRDGVAAELAEALTKEGAALEMEEQALWKEEQALREE
                     NKALREEHGALQDEEVALQEEARILQEWNNLLQGKITNNLPENMNNQDPEKCELRM"
     misc_feature    <290..>901
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <290..>901
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    <614..>913
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
     misc_feature    <614..>913
                     /gene="Golga6l9"
                     /gene_synonym="RGD1306441; Spertl"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; Region: ClpA; COG0542"
                     /db_xref="CDD:440308"
ORIGIN      
        1 agaaaccagg ctacaagtga cttagagaac acagcaatcg ggcctgtctg agcattgtgg
       61 tccattaaga agtcaacaga cagccaagac tacatgaaca aatttagtac attttctgtt
      121 gagattatca gtagtgcacc gaaaaacaat gaatatctct ggatcaaaac aaatacacaa
      181 aaggaaaata ctgcggttgt tttcttgttt ctcttgtacc caaaatcaaa agaaactcaa
      241 acataaatcc caggacgtgg aaaaaaaact ctgtagagaa aataaggtgt tgagagatga
      301 aaatagggct ctgagaaaag acaacaaatt tctctggggc gaaaacaaag ccttaggaag
      361 agaaaataaa accttccgga tggacaacca gttcatcagg gaaagaaatc atatcctaag
      421 gcagcagaac cagctactcc ggaaggtgaa aaggttgatt tcagagaacc caaaactgtc
      481 tggggaagaa tgcaatgcct tgaacacaga aggaaggtct ttttggcaac agaatcgagc
      541 catggaagct cagatcacag ctctccggca gcaagagaaa gccttccaga atgaggccaa
      601 agccttgcat gaggagatca agtccctgtg tgaggagacc aaggctctac aacaccaaga
      661 gagggctctc aggatggaag agaaagccct gctgagggac ggagtggctg cagagctggc
      721 agaggccctg accaaggagg gagctgctct agagatggaa gaacaggctt tgtggaagga
      781 agagcaggct ctcagggagg agaacaaggc gctgagagaa gagcacgggg ctctacaaga
      841 cgaggaagtt gccctgcagg aagaggcgag aatcctccag gagtggaata atcttcttca
      901 ggggaagatc acaaacaacc tcccagagaa tatgaataac caagacccag agaagtgcga
      961 actaagaatg taaccatgaa gtcatgacaa taattgtaat tccagaacat aaaagtagaa
     1021 ttcgatcgcg taatgttatt gtcagaagcc tcagaaattg acgtgctcaa tatttggtcc
     1081 ttgaaacaaa ataaaggcct gagaaataaa ttaaaa
//
LOCUS       NM_001108728            2227 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 39 member 5 (Slc39a5),
            mRNA.
ACCESSION   NM_001108728 XM_001067058 XM_063263700 XM_343140
VERSION     NM_001108728.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Guo,H., Jin,X., Zhu,T., Wang,T., Tong,P., Tian,L., Peng,Y., Sun,L.,
            Wan,A., Chen,J., Liu,Y., Li,Y., Tian,Q., Xia,L., Zhang,L., Pan,Y.,
            Lu,L., Liu,Q., Shen,L., Li,Y., Xiong,W., Li,J., Tang,B., Feng,Y.,
            Zhang,X., Zhang,Z., Pan,Q., Hu,Z. and Xia,K.
  TITLE     SLC39A5 mutations interfering with the BMP/TGF-beta pathway in
            non-syndromic high myopia
  JOURNAL   J Med Genet 51 (8), 518-525 (2014)
   PUBMED   24891338
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Dufner-Beattie,J., Kuo,Y.M., Gitschier,J. and Andrews,G.K.
  TITLE     The adaptive response to dietary zinc in mice involves the
            differential cellular localization and zinc regulation of the zinc
            transporters ZIP4 and ZIP5
  JOURNAL   J Biol Chem 279 (47), 49082-49090 (2004)
   PUBMED   15358787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_063263700.1, NM_001108728.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.28438.1,
                                           SRR26643287.17147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000007.1  1415280-1415407     c
            129-439             JAXUCZ010000007.1  1414482-1414792     c
            440-793             JAXUCZ010000007.1  1414040-1414393     c
            794-974             JAXUCZ010000007.1  1413518-1413698     c
            975-1137            JAXUCZ010000007.1  1412621-1412783     c
            1138-1307           JAXUCZ010000007.1  1412295-1412464     c
            1308-1448           JAXUCZ010000007.1  1411933-1412073     c
            1449-1542           JAXUCZ010000007.1  1411489-1411582     c
            1543-1695           JAXUCZ010000007.1  1411249-1411401     c
            1696-1776           JAXUCZ010000007.1  1411018-1411098     c
            1777-1967           JAXUCZ010000007.1  1410697-1410887     c
            1968-2227           JAXUCZ010000007.1  1410097-1410356     c
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2227
                     /gene="Slc39a5"
                     /note="solute carrier family 39 member 5"
                     /db_xref="GeneID:362812"
                     /db_xref="RGD:1310322"
     exon            1..128
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..439
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            440..793
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    492..494
                     /gene="Slc39a5"
                     /note="upstream in-frame stop codon"
     CDS             510..2111
                     /gene="Slc39a5"
                     /note="zinc transporter ZIP5; solute carrier family 39
                     (metal ion transporter), member 5; solute carrier family
                     39 (zinc transporter), member 5"
                     /codon_start=1
                     /product="zinc transporter ZIP5 precursor"
                     /protein_id="NP_001102198.1"
                     /db_xref="GeneID:362812"
                     /db_xref="RGD:1310322"
                     /translation="MGPPVHHLLAGLCVGVALGWVEGSVPNLGPAEQEQNHYLAQLFG
                     LYGENGTLTAGGLARLLHSLGLGRVQGLRLGHQEPPTGRAAPMSGDNFTHRLQELELS
                     VDVWAGMPLSPSGWGDQEDSKAHDLHGSGPSGLDLFHRLLLLDHSLADHLNEDCLNGS
                     QLLVNFGLSPVAPLTPRQFALLCPALLYQIDSRVCIKTPAPAPPGDALSALLHSGLAV
                     LFLSLPAPFSLLLLRLLGPRLLRPVLGFLGALAVGTLCGDALLHLLPHAQGGRHTGPS
                     EQAEEDLGPGLSVLGGLFLLFVLENALGLVRHRGLRPRCGRNKRDVEEPNPDPEDGTG
                     MVLRPLQAASEVQGQRENSQSLPSPAPPGYQGHSHEHRGGSIAWMVLLGDCLHNLTDG
                     LALGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQEGLSFRKLLLLSLVSGVLGL
                     GGAALGVGLSLGPVPLTPWVFGITAGVFLYVALVDMLPALLRPPEPRPLPHVLLQGLG
                     LLLGGSLMFTIALLEEQLLPVVPDG"
     sig_peptide     510..578
                     /gene="Slc39a5"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    1131..1976
                     /gene="Slc39a5"
                     /note="ZIP Zinc transporter; Region: Zip; pfam02535"
                     /db_xref="CDD:396884"
     misc_feature    1131..1976
                     /gene="Slc39a5"
                     /note="ZIP Zinc transporter; Region: Zip; pfam02535"
                     /db_xref="CDD:396884"
     exon            794..974
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1137
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1307
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1448
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1542
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1695
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1776
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1967
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2227
                     /gene="Slc39a5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaagcctg cccctttaag gtagtgtccc tcccctaccc cctccctgca ggtgaccctt
       61 gtccagcctg cctgccacaa gaaggctggg tcccccttcc tcttttgtgt ctcctgtcct
      121 gctgtcagcc ctctatgtga cgtggcttcc actgcatctg aagactgaac tccctgactc
      181 agaaatctct taaggtccac agtgaggccc tccagggacc tgaggtgcca ttaggagtga
      241 ggccctgcat atgtgggggt gaggggagta gggcggtgga acaggttaag aggtgggtct
      301 tggggatctg agatactagt ctggtttcta gaccagacct aaggagagct ctggggtcag
      361 gaggctgctc cagaaggcag aaggaagggg cagagtaagc ctgaggctgc agaggctgca
      421 gaggctgcag atagactcag gtacaatcct caggatgtcc caaaggaaat agaagtcaga
      481 accagagcct ctaacccata gccctagtga tggggccccc cgtacatcat ctgttggctg
      541 gcctgtgtgt gggggtggcc ttgggctggg tagaaggctc agtccccaac ctgggcccag
      601 ccgaacagga acagaaccac tacctggccc agctgttcgg tctatatgga gagaatggga
      661 cattgactgc tgggggcctg gcccggcttc tccacagcct aggactgggc cgagttcagg
      721 ggctccgcct gggacaccaa gagcctccaa ctgggcgggc tgcacccatg agtggcgaca
      781 atttcacaca caggcttcag gaactggagc tgagtgtgga tgtctgggca ggaatgcctc
      841 tgagcccttc aggttggggt gaccaggagg actcaaaggc acatgacctg catgggtcag
      901 ggccctcggg cctagacctc ttccacaggc ttctgctgct ggaccattcg ttggctgacc
      961 atctgaacga ggattgtctg aatggttccc agctgctggt caattttggg ctgagtcctg
     1021 ttgctcctct gacccctcgt cagtttgctc tgttgtgccc agccctgctt tatcagattg
     1081 acagccgtgt ttgcatcaaa acccctgctc cagcacctcc aggggatgca ctgtctgccc
     1141 tgcttcatag tggcctggca gtcctgttcc tcagcctccc tgctcccttc tccctgctgc
     1201 tgctgcggct cttaggacct cgtctgttgc ggcctgtgct gggcttcctg ggggccctgg
     1261 ctgtgggcac tctttgtggg gatgccctgc tccacctgct gccacatgca caaggaggac
     1321 ggcacacagg acctagtgag caagcagagg aggatctggg tccagggctg tcagtgcttg
     1381 gtggcctctt cctgctcttc gtgttagaga atgcactagg acttgtgcgg cacagagggc
     1441 tcaggccaag gtgtggcagg aacaaaaggg atgtcgaaga accaaaccct gacccagagg
     1501 acggcactgg gatggtcctt cggcccctac aggcagcttc agaggttcag ggccagaggg
     1561 aaaacagcca gtccctacca tctccagccc ctcccggata ccaaggccac agtcatgagc
     1621 accggggcgg tagtatcgca tggatggtcc tcctgggaga ttgcctgcac aacctcaccg
     1681 atgggctcgc actaggtgct gccttttccg acggcttctc cagtggcctc agcactaccc
     1741 tagcagtctt ctgccatgag ctgccccatg aactgggtga ctttgcaatg ctgcttcagg
     1801 aagggctgtc ctttcggaag ctgctgctgc tgagcctcgt ctctggagtc ctggggctgg
     1861 ggggtgcagc cctgggggtg gggctcagct tgggccctgt ccccctcact ccctgggtgt
     1921 ttgggatcac ggctggggtc ttcctctatg tggcccttgt ggatatgctg ccagccctgc
     1981 tccgtcctcc tgagccccgg cccctgcccc atgtgcttct gcaggggctg gggctgctgc
     2041 tggggggcag cctcatgttt actatagccc tgttggagga acagctactg cccgtggttc
     2101 ctgatggctg atgtgggcca gtggcaaagg atgcaggctg cccttccttc cccccaccac
     2161 aggaacggag gcgggacaca gggccagtag gagcaatagg attttaataa acagaaccca
     2221 tcccaaa
//
LOCUS       NM_001437931            8936 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus chromobox 5 (Cbx5), transcript variant 1, mRNA.
ACCESSION   NM_001437931 XM_008765707
VERSION     NM_001437931.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8936)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8936)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 8936)
  AUTHORS   Whelan,G., Kreidl,E., Wutz,G., Egner,A., Peters,J.M. and Eichele,G.
  TITLE     Cohesin acetyltransferase Esco2 is a cell viability factor and is
            required for cohesion in pericentric heterochromatin
  JOURNAL   EMBO J 31 (1), 71-82 (2012)
   PUBMED   22101327
REFERENCE   4  (bases 1 to 8936)
  AUTHORS   Yu,Y.H., Chiou,G.Y., Huang,P.I., Lo,W.L., Wang,C.Y., Lu,K.H.,
            Yu,C.C., Alterovitz,G., Huang,W.C., Lo,J.F., Hsu,H.S. and
            Chiou,S.H.
  TITLE     Network biology of tumor stem-like cells identified a regulatory
            role of CBX5 in lung cancer
  JOURNAL   Sci Rep 2, 584 (2012)
   PUBMED   22900142
REFERENCE   5  (bases 1 to 8936)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   6  (bases 1 to 8936)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 8936)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 8936)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   9  (bases 1 to 8936)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   10 (bases 1 to 8936)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_008765707.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.935915.1,
                                           SRR26360194.731855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000007.1  136253383-136253478 c
            97-279              JAXUCZ010000007.1  136227163-136227345 c
            280-466             JAXUCZ010000007.1  136218085-136218271 c
            467-567             JAXUCZ010000007.1  136213218-136213318 c
            568-8936            JAXUCZ010000007.1  136203827-136212195 c
FEATURES             Location/Qualifiers
     source          1..8936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..8936
                     /gene="Cbx5"
                     /note="chromobox 5"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
     exon            1..96
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            97..279
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Cbx5"
                     /note="upstream in-frame stop codon"
     CDS             143..718
                     /gene="Cbx5"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_001424860.1"
                     /db_xref="GeneID:300266"
                     /db_xref="RGD:1306619"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKESAKS"
     misc_feature    197..346
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    197..346
                     /gene="Cbx5"
                     /note="chromodomain of heterochromatin protein 1 homolog
                     alpha; Region: CD_HP1alpha_Cbx5; cd18651"
                     /db_xref="CDD:349298"
     misc_feature    order(197..208,257..259,263..265,296..298,308..328)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    order(197..208,257..259,263..265,296..298,308..328)
                     /gene="Cbx5"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349298"
     misc_feature    488..661
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    488..661
                     /gene="Cbx5"
                     /note="chromo shadow domain of heterochromatin protein 1
                     homolog alpha; Region: CSD_HP1alpha_Cbx5; cd18655"
                     /db_xref="CDD:349302"
     misc_feature    order(515..517,521..535,557..559,584..586,644..646,
                     653..658)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(515..517,521..535,557..559,584..586,644..646,
                     653..658)
                     /gene="Cbx5"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349302"
     misc_feature    order(527..529,641..649,653..658)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(527..529,641..649,653..658)
                     /gene="Cbx5"
                     /note="putative binding pit [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(611..613,623..628,632..637,644..649)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     misc_feature    order(611..613,623..628,632..637,644..649)
                     /gene="Cbx5"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349302"
     exon            280..466
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            467..567
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            568..8936
                     /gene="Cbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgcgcaga aggcggcggt agcggtggct tgtggtgccg ctttgccaca gaggaaccgt
       61 gcaggcctta gtgtgagtga tcactttaga tcccgggaac ctggtggccg cactccttta
      121 ggtggaccaa cacataccca acatgggaaa gaagaccaag aggacagccg acagctcttc
      181 atcagaggat gaggaggagt atgtggtgga aaaggtgttg gacaggcgca tggttaaagg
      241 gcaagtggag tatctgctga agtggaaagg cttttctgag gagcacaaca cttgggaacc
      301 tgagaagaac ttggattgtc ctgaactaat ttctgagttt atgaaaaagt acaagaagat
      361 gaaggaggga gagaacaaca agcctaggga gaagtcagaa ggaaacaaga ggaaatccag
      421 tttttccaac agtgctgatg atattaaatc caaaaaaaag agagagcaaa gcaatgatat
      481 cgctcggggc tttgagagag gactggaacc agaaaagatc attggggcga cagattcctg
      541 tggagactta atgttcttaa tgaaatggaa agacacagat gaagctgacc tggtccttgc
      601 aaaagaagct aatgtgaaat gtccacaaat tgtgatagca ttttatgaag agagactgac
      661 gtggcatgcg tatccagagg atgcggaaaa caaagaaaaa gaaagcgcaa agagctaaag
      721 gaggaggcag tctctgtcat ttctctttgt atataatacc ttcaccttcc tgcctcctct
      781 cgcttctccc gtccctttcc atcctaaaca tatccataaa aatgatgtgc ttatcaatca
      841 ctgtgctcca cgggagagat gttggtattg gttcccttgt aatataactg atggtctgac
      901 tcctaagtgt agctctgtga aagtcaggca ttacatcctt cacatgctgt gtggttccca
      961 tagtgttctc tttcatcctg atcttttcct tctgttccct gtaactttta atcaccttag
     1021 agtcgtgatc tttggggttg gttgctttgg ggaattttat tataatgacg atgacttcag
     1081 tttcttggtt gttaattaga atatattgat gaccagctgg cctttgtttt gacatactgg
     1141 catagaaagg atgttgtcca gcttttagaa agctaatagc agcagcctac atgttgtgta
     1201 ttttttaatc tcacttagct ctgccaggag aatacagggt ccctggtgtg gtcttctggg
     1261 ccactcctga ctattctcac ctaccctccc ataacaactc agttctcttg agggcttgag
     1321 actttacact gtttagccct cacactcttt tggcttcgtt actttcaatc cctgattctg
     1381 cttctgtaaa gtgtatcagt ttgttattaa atgacaggat taactgtggg gtctgtaagc
     1441 tgtagtgcag gacgataaca ggacggggct ggatgcggtt gtctttggta tcacatggtg
     1501 tgcatgtgtt ctttccttca ccctcattcc tagactctat ttatgtaggt gtagggactg
     1561 cctggtgctt gcttgtgcca agcaccctgc caacttttat ggcctcccaa agcattcctg
     1621 taccaaagag gaatcagcag atccacacat tcccttccgt gccgttattt taagttggga
     1681 attgttagaa aggaaccatt agccacagtg tcatcagttt ctaaatcctc acagcagtga
     1741 tagatactct ttaactttac cactaagtcc ctagaggatt aatgttcctg ccctctccat
     1801 cctcagactt ttagttgtag cttattttaa aaactatttt catggaagac catcgcctca
     1861 gaaaccaaca ggtcttgaca ttagcttttt gacacaacct tctcccacaa caaactactc
     1921 ctttttgatt tactcttact ttgctattat ttctgctcct gttctgttct ttttgtcccc
     1981 tgaaaatgtc catcttctct tcattccttt cttcttatat agttgaggag actgagaatc
     2041 aggactaaat gtaaggaaat aacagggttt ggagctgagc actctttttt ttttttttcc
     2101 cccccccccg gagctgggga ccgaacccag ggccttgcgc ttcctaggta agcgctctac
     2161 cactgagcta aatccccagc cccaggagct gagcactctt gacccagctc aaaagctgag
     2221 gaaaaggagt aaacgctgag atagccttaa ttctagactt tatcaactac tgaggctgtt
     2281 tttgttgttc ctttcggttt ttaaagcata gctatctgag cagccaccca tttctagatc
     2341 gttcatggta atgaggggaa ggagtggagt gctctggtcc acagatgacc caagtgtgtg
     2401 cacgtcctag acccattcag tgtttgctag catcacttct ctgctcagct gccactgagc
     2461 tctgtgttct tgaataaatt atgtcaacaa ttatactgca cagttgacag gacagccagg
     2521 aagaacctgt gaatggtact gtggtagggg aagagcacct aacccttacc tctccgtagt
     2581 tcattctctg aagatggtag aggcaagctc aaaggctgga taagtgacca ttgtctgctt
     2641 aacttgatga aatgcaggtg gttagagagc agatgtgtcc ttcacgcaac ctagactagt
     2701 aattagggca gatgaaggta gcccagaagt ggcccagttc ctgaggatct tagtctctga
     2761 ttagcagctg gagggaagga cagcctgctg agcactcagc agcagtgggc tgtaaactgg
     2821 cagtggaagg actgagtata cagtttgagg atttaatgcc ttgtaatgca aaaaatgaag
     2881 ggaaggagtg gcctgctggt tttaatgctc tttacaatgt ttttccctct caaaagttca
     2941 tggagtattg gttttctgtt aattattacc aaaactctct tgtccgtgtc tccccccccc
     3001 cccccccagc tggggaccga acccagggcc ttgcgcttgc taggcaagtg ctctaccact
     3061 gagctaaatc cccaacccct tgttttcctc ttagtaagtt tcctggttat atatagaaat
     3121 agggaaccgg gattccagta ttctcttcag ctctcagtat gaagaagcca gacacccatt
     3181 tgtgcctcca gcctgtgttg tgccaagtag cttgattctg ctggagaatt gcagctgtgg
     3241 acaaaagtgt ttcctagagt tatcttctat cttcgctcta aagagttcat ggccaaaggt
     3301 gaaagaaata ctcctaaaca ctgactatat tctcctgtgt taaccctctc cagaactaat
     3361 tttgtggtac tggaaattga acctaggacc agcgtggaca gccgggcaac tgctgtgcca
     3421 tttttgtctg ccccctttcc tcccctgcca tacagttgat ggatcaccaa attcacctgt
     3481 ttttgttgct ctaaggactt taagtcactg ataccaagct aaccttggtt gtataaccaa
     3541 gttgaattct tttttttttt tttttaaact tatgtgacta tgttgttgct gtcttcagac
     3601 acaccagaag aaggcatcgg atcacattac agatggttgt gagccaccat gtggttgctg
     3661 ggatttgaac tcaggacctc tggaagagca gtcagtgctc ttaaccactg agccatcctc
     3721 cagccctgct aagttgaatt ctttttttct ttttttcttt ttctttttct tttttccgaa
     3781 gctggggacc gaacccaggg ccttgcgctt gctaggcaag cgctctacca ctgagctaaa
     3841 tccccaaccc cctaagttga attcttgatc tcctgcctct tcccagtctc taggattata
     3901 ggtatgtgcc accatatctg gctcttagct ccttctatat ggagttatct gtgctagcca
     3961 ggtacagtgt aatacacctt tatttccagt ctttaggagg cagaagtaga taaatcttaa
     4021 tcggaggcct gcctggacta tatagtgagt tctaggccag ccacacctac atagatcttg
     4081 ttgtgaaagg aaaaatagga aaagagtacc cagattggcc ttgaacttag gatctttatg
     4141 tatcagttgt atgccactat gcctggctca aaatgccttt ttttttcttt attaacttga
     4201 gtatttctta tttacatttc gatttttttt aagttatata tatatgtgat ttctgcctgc
     4261 atgtatatgc accatatgca tgcctggttc cctaggagac agaagagggt ctcatatcct
     4321 cttagatagg agtgagccac tatgtgggtg ttgagaatca gatctggaag agtagtcagt
     4381 gctcttaact gctgagccat ctcccaccct tcaaaacatc tttctaaagt tgaatttctt
     4441 cccccccccc ttttctgttt agtcctgact gtttcttgct ggcttcaccc tctagtgctc
     4501 acgttttgct agctttgtgc aaaaacaggt gaactgggtg atccatcctc aattttacac
     4561 attgtgttgt tcacatttct acaactttag catacatcaa tattgttttc attcaacaaa
     4621 cagttttggc tcaggaactc gctagagaac tttgatagtg gtgtgggatg agttgatcag
     4681 tatagttttg gataatgaat actgcacatg tatataaatt actggtctgg gacagcatca
     4741 ggtatacaaa aaggtgagtc tttagtgggc agttagttaa gtggttgagt gctggtgagg
     4801 aatccatgaa gccctgggtt tccacggggg ggggggtaag gtaaatctgc agtaggaggg
     4861 gggggtaagg taaatctgca gtaggagggg ggggtaaggt aaatctgcag taggagggtg
     4921 ccattaactg cttcatctgt gggaaagact gtggtcttgg atgaactgag ttaactggcc
     4981 atgggcagca ttgcaggaaa taaagctaga aaggctttcg tttcgttacc aagagtgcag
     5041 atgaatgagc gtgagaactg tcttgtttag actgccaagc attcatgact gtgttagtat
     5101 tgcctgtgct ggtgtatatt tcttctttgt gggcgtttta gcaagttgct cacactgttc
     5161 aatttctcac ccttttggag aaatcaacat tagtctggct ttaaagccca aaacatacca
     5221 tctaatgaca agacttcctt agaacaaagc ttaggaatga gctacctttg gatcacgtgg
     5281 gtctcagtgc cagggagtaa gcagctcctg tgtcacttat atcaaaacct tccacaggaa
     5341 taatgtgctc tggctcctca ttgtgcgtga cacccttctc agagaaggaa aggtctgttt
     5401 ttcaggttct tattctgact cctgagagcc caagacgaag atgtaattga ctgactttag
     5461 aagtcagaat tcccagaaat tcaactaact gctctagaag gttaaaatgt gaagtttctt
     5521 gtttgttttt tgcttgtgct gaatattttg aattttcatc tacctcgtct tatttttctt
     5581 agttacttct gtcattacca cttgagcatc aagcttgatt ttggtcattg tctaaaatgg
     5641 ggtctctcct gttcagtgac agtttattcc cttgtctttc ctcttggccc tcatttcacc
     5701 taacatcatc tcttattgct cctgtcagaa atatgtttta aagtcttgtt ttatgggaaa
     5761 aagtggtcca ccaatgctgt ttgtctctga ggtcagtgag agaaggagtt aaaacacagt
     5821 ggtggaggaa gggcagagcc tgcctgcact ggaggcaaaa gctgacaagg aaggagtcat
     5881 taattaaaga caatttcaaa gtcaactgat tgtgatcatt aatgtcacaa tagatcaaaa
     5941 cctaattatc acagcctagg taagagccat cagtattaat cggaaaatct aataggaaac
     6001 tattagcaag aaattaggcc aaattgaatg caatgaactt tttatcatct ttttttggta
     6061 atgttcttgg tgttggcaac tgtgacccta acagttggtc caagcccaga ttgctaattt
     6121 taaagagcct tttttttttt tttttttaag taacccaggc tgaccctagt gcttacagcc
     6181 ctccagcttc agccttgagc actgggatta tgaggggtac atgcatttgt gtttgtgtgg
     6241 gtgggtagga gagaattgaa ctcagggcct tgtacatttt agacaagtgc tctaccactg
     6301 aactgtattc ctagctcaga gtgttttgtt tgttagggaa gtttccagac agactgaacc
     6361 taagctgaca ttgctgaaac accagccttg aattttttta tcatatggat ctattcattc
     6421 taatcagatc agcgggatat aaacatatat attaaagtcg tagagtgtcc ctagtgaaca
     6481 tcatatcatc tgttgagtgc ttgtatatag agttctatac tggttgttgt gaaggctgtg
     6541 ggaggaaggc agtgtcctgc tttgaaattc tttgaaaact aaaaagatag tttccttgtg
     6601 tgacagcatg atcaagatgc aagtctgtgt ttttcagttt ccattagcat tagggtttga
     6661 tcctaaacca gcttagcagt gcccccaacc ccaatagttt taagataggc acaaaatgat
     6721 ttcctactgg aattctaagg tatggggaag acatctttgt ttctgttttc ctttctggta
     6781 gtaggagaag catcagtatg tccttaagat gtttgtaaag atgctacccc ctttaggtga
     6841 gatgagtcag gctgtggaac ggttgctgtc acaggaggag tgccaggcag tagtagaggg
     6901 aattgtgctt aggagtctgc actgtgccct gcagccctca gatgctcagt gctgacctta
     6961 ggaggcccat gctgctttct ggaccttggg aacctggatt acccagtaga agactgagaa
     7021 tcaatgtctt ttgtttgttt gtttattttt tgttctgttt ttgttttgtt ttgttttgtt
     7081 ttccaagatg gggtctctgt gtagccatgg atgtcctgga acttgctctg ttgaccagac
     7141 tggcctcgaa ctcaaagatc tgcctgcccc tgcctcccaa gtactgtgat caaacgtgtg
     7201 cgccatcact gcctggctaa cccttcactt cttagtgagt tttagtgttt aaaaaatgca
     7261 acttaatttt caaagtggca ctaaggtggt ttgtccagcc ttgggttact ccaggtgagc
     7321 agcagccctc aattaacagt gtgttgattg gactcatccg gctgcagtga aatgactgaa
     7381 agtgagatgt tctagtgcat agttctgtgc taacctccta cttggtctta atggctgacc
     7441 ttgggcaagt ctttcctttc aatgcctcag ttccccatct gtcaaatggg gtgataatac
     7501 tgacctacct catggggtgt tgtgaggcat tacagatcag agctgatcaa ccctttagga
     7561 ttgcctgtgg aggatacctt aagtcggact cttttagccc tcactgagct acttccaagt
     7621 ttggaagtag ttagtgacct tggcgagttt ctgtcccccc accctttacc cctcatcaaa
     7681 gctgctagtt cagatgttaa cagtgttttg tgaatgttgg agtcttgatc gtccagtcta
     7741 acttgggaca atgtaaggga aggcacttgt gggttctgtg tcttatatta caaagagact
     7801 gttagaaatt caagagcctt ggtttaggaa tcttgaggca ggaatgctac cgcatgtctt
     7861 tctctgcagg agttaaggtc ctattctcat ggacttataa ctacttctga ctgtcttcga
     7921 aaggaagtga cacttggtat tttggattta tattgttgct ttcattttcc agactgatcc
     7981 taggacagtt agtctactga acccttcatg cttctatgcc tctgccctct catagaagcc
     8041 agatggttca agcaacatag ctctcccttc ccccaccaaa aagctgtatt ggatttttgt
     8101 ttttttgttt ctagaaatag gtgtaacatt tcagaattga gcattggtcc tcaaggcttc
     8161 ttccagttca ctgtgtgtgg aatctgtcac ctcttttcag tgtccaccat ctgacccact
     8221 gaggacatct tggacacttg tttgcccact tgagggttca aaagccttac tctgtgtttc
     8281 agtatagggc taaggcatcc ccaagctctt cgtgataggt ttcctttccc ctacttgacc
     8341 ttgtattggt accatgaaaa agcacacagt cctagctccc tggaggtaca cactccagta
     8401 ctgttaggtg gactctactc ctaacaggga tcctagaggg ttctctggag gatgggaaag
     8461 gagcagtctc atgtcctgcc aagtagtagc cagcagttgc cttacccctg cctgctggcc
     8521 atgttcccac ctcctcatgg agagggcttt cagaggtcct cgaggctgga ttttctcagt
     8581 ctctgctgtg ccattctgag tgggaagcag accacacttt gtggccaggt gtctaagtgg
     8641 aagtgaggtc ttgaattctc ggtggacttt ttggtttgtg ggggagtttt ggttgtgttt
     8701 cttggttcta tttcagccaa actcgcctgc ttttgatttc tttaaaggat aagtggtcta
     8761 tctatctata tacatgtatg tttgcatttt aagtgtaaat gttttgaaaa aaaaaaacag
     8821 acatgtcttt ctataactga catccgattc agacatcatt ctctcccctt ccaccctctt
     8881 ttccctcttt tcatactctt gtattggttc taataaagga ttgcttttca aatatg
//
LOCUS       NM_001108561            3435 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus adenosylhomocysteinase-like 1 (Ahcyl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001108561 XM_001068488 XM_342312
VERSION     NM_001108561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Harvey,K.E., LaVigne,E.K., Dar,M.S., Salyer,A.E., Pratt,E.P.S.,
            Sample,P.A., Aryal,U.K., Gowher,H. and Hockerman,G.H.
  TITLE     RyR2/IRBIT regulates insulin gene transcript, insulin content, and
            secretion in the insulinoma cell line INS-1
  JOURNAL   Sci Rep 12 (1), 7713 (2022)
   PUBMED   35562179
  REMARK    GeneRIF: RyR2/IRBIT regulates insulin gene transcript, insulin
            content, and secretion in the insulinoma cell line INS-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Borth,H., Weber,N., Meyer,D., Wartenberg,A., Arlt,E., Zierler,S.,
            Breit,A., Wennemuth,G., Gudermann,T. and Boekhoff,I.
  TITLE     The IP3 R Binding Protein Released With Inositol
            1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and
            Spermatozoa
  JOURNAL   J Cell Physiol 231 (5), 1114-1129 (2016)
   PUBMED   26439876
  REMARK    GeneRIF: The present study documents that IRBIT is expressed in
            Leydig and Sertoli cells.
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Ando,H., Hirose,M., Gainche,L., Kawaai,K., Bonneau,B., Ijuin,T.,
            Itoh,T., Takenawa,T. and Mikoshiba,K.
  TITLE     IRBIT Interacts with the Catalytic Core of Phosphatidylinositol
            Phosphate Kinase Type Ialpha and IIalpha through Conserved
            Catalytic Aspartate Residues
  JOURNAL   PLoS One 10 (10), e0141569 (2015)
   PUBMED   26509711
  REMARK    GeneRIF: IRBIT forms signaling complexes with PIPKIalpha and
            NBCe1-B, whose activity is regulated by PI(4,5)P2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Park,S., Shcheynikov,N., Hong,J.H., Zheng,C., Suh,S.H., Kawaai,K.,
            Ando,H., Mizutani,A., Abe,T., Kiyonari,H., Seki,G., Yule,D.,
            Mikoshiba,K. and Muallem,S.
  TITLE     Irbit mediates synergy between ca(2+) and cAMP signaling pathways
            during epithelial transport in mice
  JOURNAL   Gastroenterology 145 (1), 232-241 (2013)
   PUBMED   23542070
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   He,P., Klein,J. and Yun,C.C.
  TITLE     Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated
            by inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein
            kinase II
  JOURNAL   J Biol Chem 285 (36), 27869-27878 (2010)
   PUBMED   20584908
  REMARK    GeneRIF: IRBIT is critically involved in mediating activation of
            NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases
            II-dependent pathway.
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Yang,D., Shcheynikov,N., Zeng,W., Ohana,E., So,I., Ando,H.,
            Mizutani,A., Mikoshiba,K. and Muallem,S.
  TITLE     IRBIT coordinates epithelial fluid and HCO3- secretion by
            stimulating the transporters pNBC1 and CFTR in the murine
            pancreatic duct
  JOURNAL   J Clin Invest 119 (1), 193-202 (2009)
   PUBMED   19033647
REFERENCE   8  (bases 1 to 3435)
  AUTHORS   He,P., Zhang,H. and Yun,C.C.
  TITLE     IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3
            activity in response to calcium
  JOURNAL   J Biol Chem 283 (48), 33544-33553 (2008)
   PUBMED   18829453
REFERENCE   9  (bases 1 to 3435)
  AUTHORS   Shirakabe,K., Priori,G., Yamada,H., Ando,H., Horita,S., Fujita,T.,
            Fujimoto,I., Mizutani,A., Seki,G. and Mikoshiba,K.
  TITLE     IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein,
            specifically binds to and activates pancreas-type Na+/HCO3-
            cotransporter 1 (pNBC1)
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9542-9547 (2006)
   PUBMED   16769890
REFERENCE   10 (bases 1 to 3435)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342312.3, XM_001068488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3435
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="adenosylhomocysteinase-like 1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
     exon            1..114
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    58..60
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="upstream in-frame stop codon"
     exon            115..226
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1563
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /EC_number="3.13.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     S-adenosylhomocysteine hydrolase-like 1; putative
                     adenosylhomocysteinase 2; adoHcyase 2;
                     S-adenosyl-L-homocysteine hydrolase 2;
                     S-adenosylhomocysteine hydrolase-like protein 1;
                     IP3R-binding protein released with inositol
                     1,4,5-trisphosphate"
                     /codon_start=1
                     /product="S-adenosylhomocysteine hydrolase-like protein 1
                     isoform 1"
                     /protein_id="NP_001102031.1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
                     /translation="MQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSP
                     REKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIV
                     GCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDD
                     FWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQL
                     SKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVG
                     KGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVT
                     REHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAE
                     GRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDTNGRITMT
                     SPHEPRNSNRVFFKITFIFFLLLSF"
     misc_feature    136..303
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    187..270
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: PEST. /evidence=ECO:0000250|UniProtKB:O43865,
                     ECO:0000250|UniProtKB:Q80SW1"
     misc_feature    196..198
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine, by PKD.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    205..207
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    214..216
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    223..225
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    244..246
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80SW1; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     misc_feature    310..1461
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    310..1461
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="S-adenosyl-L-homocysteine hydrolase; Region:
                     AdoHcyase; smart00996"
                     /db_xref="CDD:214963"
     misc_feature    order(337..339,346..348,358..360,367..372,772..774,
                     781..786,832..834,838..840,850..855,865..867,874..879,
                     889..891,898..903,910..930,952..957,964..966,991..996,
                     1000..1002,1015..1041,1045..1056,1060..1071,1078..1080,
                     1117..1131,1159..1167,1198..1200,1249..1254,1267..1269,
                     1339..1341,1345..1347,1351..1356,1363..1365,1441..1443,
                     1459..1461)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    order(337..339,346..348,358..360,367..372,772..774,
                     781..786,832..834,838..840,850..855,865..867,874..879,
                     889..891,898..903,910..930,952..957,964..966,991..996,
                     1000..1002,1015..1041,1045..1056,1060..1071,1078..1080,
                     1117..1131,1159..1167,1198..1200,1249..1254,1267..1269,
                     1339..1341,1345..1347,1351..1356,1363..1365,1441..1443,
                     1459..1461)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:240619"
     misc_feature    406..597
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: Interaction with BCL2L10.
                     /evidence=ECO:0000250|UniProtKB:O43865"
     misc_feature    order(451..453,457..459,463..468,679..681,754..759,
                     844..846,856..858,1327..1329,1342..1344,1357..1359,
                     1369..1371)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(451..453,457..459,463..468,679..681,754..759,
                     844..846,856..858,1327..1329,1342..1344,1357..1359,
                     1369..1371)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(757..765,859..861,871..873,946..948,952..960,
                     1012..1023,1030..1032,1111..1122,1129..1131,1183..1191,
                     1318..1320,1324..1326,1342..1344)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    order(757..765,859..861,871..873,946..948,952..960,
                     1012..1023,1030..1032,1111..1122,1129..1131,1183..1191,
                     1318..1320,1324..1326,1342..1344)
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="NAD binding site [chemical binding]; other site"
                     /db_xref="CDD:240619"
     misc_feature    835..1338
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DFN2.2);
                     Region: NAD binding. /evidence=ECO:0000250"
     misc_feature    1165..1167
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43865; propagated from
                     UniProtKB/Swiss-Prot (B5DFN2.2); phosphorylation site"
     exon            227..370
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            371..471
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            472..574
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            575..669
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            670..776
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            777..893
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            894..957
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1046
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1117
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1212
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1311
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1380
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1459
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..3435
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgcgacag acttttcctg gatggaggag ggccttgaag acgagattgg gagggggtga
       61 acgactcatc tgacctgtcc aggggatgag ggtgtgcagg aaatttcccc tcagcaaatc
      121 cagtttgcgg atgacatgca agagttcacc aaattcccta ctaagactgg ccggagatcc
      181 ttgtctcgct ccatctcaca gtcctccaca gacagctaca gttcagctgc atcctataca
      241 gatagctctg atgatgaggt ttccccccga gagaagcagc aaaccaactc aaagggcagc
      301 agcaatttct gtgtgaagaa catcaagcag gcagagtttg gacgccggga gattgagatt
      361 gcagagcaag acatgtctgc tctgatttca ctcaggaaac gtgctcaggg agagaagcct
      421 ttggctggtg ctaaaatagt gggctgtaca cacatcacag cccagacagc ggtattgatt
      481 gagacacttt gtgccctggg ggctcagtgc cgctggtctg cctgcaacat ctattcaact
      541 cagaatgagg tagctgcagc actggctgag gctggagttg cagtgtttgc ttggaagggc
      601 gagtcagaag atgatttctg gtggtgcatt gaccgctgtg tcaacatgga tgggtggcag
      661 gctaacatga tcctggatga tgggggagac ttaacccact gggtttataa gaagtatcca
      721 aacgtgttta agaagatccg aggcattgtg gaagagagcg tgactggtgt tcacaggctg
      781 tatcagctct ccaaagctgg gaagctctgt gttccagcca tgaatgtcaa tgattctgtt
      841 accaaacaga agtttgataa cttgtactgc tgccgagaat ccattttgga tggcctgaag
      901 aggaccacag atgtgatgtt tggtgggaaa caggtggtgg tgtgtggcta tggtgaggta
      961 ggaaagggct gctgtgctgc tctcaaggcc cttggagcaa ttgtctacat cacagaaatt
     1021 gaccccatct gtgctctgca ggcctgcatg gatgggttcc gggtggtgaa gctgaatgaa
     1081 gtcatccggc aggtggacgt tgtaataact tgcacaggaa ataagaatgt agtgacccgg
     1141 gagcacttgg accgaatgaa aaatagttgc attgtatgta atatgggcca ttccaacaca
     1201 gaaattgatg tgaccagcct ccgcactcca gagctaacat gggagcgcgt acgttctcag
     1261 gtggaccatg tcatctggcc tgatggcaag cgggtcgtcc ttctagcaga gggtcgttta
     1321 ctcaatttga gctgctccac agttcctacc tttgtccttt ccatcacggc tacaacacag
     1381 gctttggcac tgatagaact ttataatgca ccagaaggac gctacaaaca ggatgtgtac
     1441 ttgcttccta agaaaatgga tactaatgga cgtattacaa tgaccagtcc acacgaacca
     1501 cgcaactcta atagagtatt ttttaagata acttttattt tcttcttatt actttccttt
     1561 tgattttttt ttctataatt tcattttttt tctcatctca tcatttgagt tttgcagacc
     1621 acacaggaac ttgctccatg gctgtttagg tgaaactgag gtcaaaggtt tctcaccttt
     1681 agtcactaaa aggggttaat tctgcagccc agaaagtcaa ttctttaacc atttctgggg
     1741 actttgatcg catttagtta ccatattaac agaaaatgct aaggcatctt ctgtgtggaa
     1801 caatctacag tgtctaaatt gccttaaaag agactgttct agctgctgga actagtgctc
     1861 tttacttctt cagaggagcc aggatggctc cagccaggta ggttagacgt aggtggtgca
     1921 tgtcaacttc ccgtagacag acgctctaag ccgtttcctg tctaagatgg cgtgtctgca
     1981 gagatgtgtg ctgttaaact ccgtaggctc actcggattt gtagttcagc ccttccacca
     2041 gtctctctca ttgttctagt tttaactaaa ctgcattcta tcaagttgaa ttttgtccct
     2101 tagcatttat ttgttttgtt tcttttaatt aaggaaaaat tttagtgtta atcctgagga
     2161 acagctcagg tggttagtta ccaatatctc ttttgaacct ttgaagcaaa gtgtcaagag
     2221 ttgaggctag aaaaatgcta gcctcagact ctgatgtttc cagctcatag tttatagtgt
     2281 cagtgaactg gagccataag caaaacttct cagctctgcc tcacgcagct tatgctgacg
     2341 gccgatttct tgagccatta ctcagtataa aacactgagc cctgtcctta gggtttatcc
     2401 tttcagagca aacctgtggg cagctgtgct tctgcaacct aaactgtttg aagggaagtt
     2461 tgcatagatg gaagaaagaa tgacaaattg ggccaaggtg aaacaaatat aactgtataa
     2521 tctgttcaga gctggagacc ttgtctgctg ttagttttat agacatggtg ccacttttga
     2581 ttgacacttg ccacaaaaat agaaaataaa aattgtaaac tgagatctta aagacttggt
     2641 ggagaaagta catcctgatt catgctctaa gagaattcca agagaccctc taaaatcaga
     2701 gagacttatt cccaggccac gcacccgctt gccagcatct ctgcatggtc aaacgagctt
     2761 caagctcaag ctttaggtat ataattatcc gggattttaa gtcctcagcg tgttctagct
     2821 tgtgatcctt caaagatggg ttatgtgtta atgatagata ctggaaatgt ttacttctct
     2881 ctttcactga tcagagaaac aggcattaaa aacagaaata caagaaagga aagcttttac
     2941 cctgcacctt ccttgcaggg aacaattatc ttgccaaaac ttttttccct ttcatctccc
     3001 atttctctgt acccagcccc ttcctgctcc tttccaatgt gatcatgctt tcttctctat
     3061 agatactaac atttgaagac ccctttccta aggcacttaa ccatccaatc agaacaccac
     3121 actcagtagg gccttatctt ggctaacagc agtgtattca tctggtcagc tctactggag
     3181 ggaaggggcc aagttcctgc tgccctctaa tctgccctct ggtcctatct attactgtgt
     3241 ccataggaat aataggtaag ggctagtctc tgtcaagcca tgtaacaaag gacactggaa
     3301 aatgtctggc atcagaggga acatttggag accaacttgg gaggaaaata ttcattttgt
     3361 attgaatgat ttttaatgaa tgcaatatta atccttgcag atgagcaata atcattaaag
     3421 tcaattaaaa gtgat
//
LOCUS       NM_001437970            3121 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus RIC8 guanine nucleotide exchange factor B
            (Ric8b), transcript variant 2, mRNA.
ACCESSION   NM_001437970 XM_006241180
VERSION     NM_001437970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Lopez-Benito,S., Lillo,C., Hernandez-Hernandez,A., Chao,M.V. and
            Arevalo,J.C.
  TITLE     ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated
            secretion
  JOURNAL   J Cell Sci 129 (9), 1866-1877 (2016)
   PUBMED   26966186
  REMARK    GeneRIF: overexpression of ARMS blocked NGF-mediated secretion,
            without affecting basal secretion, a decrease in ARMS resulted in
            potentiation. Similar effects were observed with synembryn-B, a
            protein that interacts directly with ARMS. Downstream of ARMS and
            synembryn-B are Galphaq and Trio proteins, which modulate the
            activity of Rac1 in response to NGF
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Aguilar,R., Grandy,R., Meza,D., Sepulveda,H., Pihan,P., van
            Wijnen,A.J., Lian,J.B., Stein,G.S., Stein,J.L. and Montecino,M.
  TITLE     A functional N-terminal domain in C/EBPbeta-LAP* is required for
            interacting with SWI/SNF and to repress Ric-8B gene transcription
            in osteoblasts
  JOURNAL   J Cell Physiol 229 (10), 1521-1528 (2014)
   PUBMED   24585571
  REMARK    GeneRIF: Results indicate that a functional N-terminus in
            C/EBPbeta-LAP* is required for interacting with SWI/SNF and for
            Ric-8B gene repression in osteoblasts.
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Chan,P., Gabay,M., Wright,F.A. and Tall,G.G.
  TITLE     Ric-8B is a GTP-dependent G protein alphas guanine nucleotide
            exchange factor
  JOURNAL   J Biol Chem 286 (22), 19932-19942 (2011)
   PUBMED   21467038
  REMARK    GeneRIF: Ric-8BFL-catalyzed nucleotide exchange probably proceeds
            in the forward direction to produce Galpha-GTP in cells.
REFERENCE   4  (bases 1 to 3121)
  AUTHORS   Klattenhoff,C., Montecino,M., Soto,X., Guzman,L., Romo,X.,
            Garcia,M.A., Mellstrom,B., Naranjo,J.R., Hinrichs,M.V. and Olate,J.
  TITLE     Human brain synembryn interacts with Gsalpha and Gqalpha and is
            translocated to the plasma membrane in response to isoproterenol
            and carbachol
  JOURNAL   J Cell Physiol 195 (2), 151-157 (2003)
   PUBMED   12652642
REFERENCE   5  (bases 1 to 3121)
  AUTHORS   Tall,G.G., Krumins,A.M. and Gilman,A.G.
  TITLE     Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein
            guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 278 (10), 8356-8362 (2003)
   PUBMED   12509430
  REMARK    GeneRIF: two mammalian homologs of the Caenorhabditis elegans
            protein Ric-8 were identified: Ric-8A (Ric-8/synembryn) and Ric-8B
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006241180.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.137525.1,
                                           SRR26643429.26098.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000007.1  20729896-20730066   c
            172-219             JAXUCZ010000007.1  20722480-20722527   c
            220-828             JAXUCZ010000007.1  20701536-20702144   c
            829-923             JAXUCZ010000007.1  20691843-20691937   c
            924-1152            JAXUCZ010000007.1  20678508-20678736   c
            1153-1248           JAXUCZ010000007.1  20677768-20677863   c
            1249-1393           JAXUCZ010000007.1  20669149-20669293   c
            1394-1538           JAXUCZ010000007.1  20658000-20658144   c
            1539-1658           JAXUCZ010000007.1  20650636-20650755   c
            1659-3121           JAXUCZ010000007.1  20636337-20637799   c
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..3121
                     /gene="Ric8b"
                     /note="RIC8 guanine nucleotide exchange factor B"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
     exon            1..171
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1770
                     /gene="Ric8b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synembryn-B; resistance to inhibitors of cholinesterase 8
                     homolog B; resistance to inhibitors of cholinesterase 8B;
                     heterotrimeric G protein guanine nucleotide exchange
                     factor-like protein Ric-8B; chaperone Ric-8B"
                     /codon_start=1
                     /product="chaperone Ric-8B isoform 2"
                     /protein_id="NP_001424899.1"
                     /db_xref="GeneID:314681"
                     /db_xref="RGD:631419"
                     /translation="MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESADEDKRK
                     KLCEGIFKVLVKGVPTTCQVPCLEVLRILSRDKKILAPVTTEENMQILLRLAKLHESD
                     DSLEKVSEFPVIVESLKCLCNIVFNSQVAQQLSLELNLAAKLCNLLRKCKDRKFINDI
                     KCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHSGPP
                     LSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEE
                     LHSNAVNLLSNVPVSCLDVLICPLTHEETAQEAATLDELPGDKTAEKDTALKSSAMVY
                     NGMNMEAIHVLLSFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPL
                     RDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAG
                     LLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPNINLITGHLEEPMPNPIDEMTEEQK
                     EYEAMKLVNMLDKLSREELLKPMGLKPDGTITPLEEALSQYSVIEETSSDTD"
     misc_feature    283..1662
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     misc_feature    283..1662
                     /gene="Ric8b"
                     /note="Guanine nucleotide exchange factor synembryn;
                     Region: Ric8; pfam10165"
                     /db_xref="CDD:462973"
     exon            172..219
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            220..828
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..923
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1152
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1538
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1658
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..3121
                     /gene="Ric8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggtag cgggggcgcg aggcgtttac ctgggaggca gcggctgggg cgcgcacagc
       61 ggctgcggct cccccgcacc tgcggccatg gatgaagagc gcgccctcta catcgtccgg
      121 gccggcgagg cgggggctat cgagcgggtc ctgagagatt acagcgacaa gcatagggct
      181 actttcaaat ttgaatcagc agatgaagat aaaagaaaga aactctgtga aggcatattt
      241 aaggtcctgg taaagggtgt cccaacaaca tgccaagtgc cctgcctgga agttctccgc
      301 attctctcca gagacaaaaa gattttagct cctgtaacaa ctgaggaaaa tatgcaaata
      361 ctgctgagac tggccaagct ccatgagtcg gacgattctt tggagaaggt gtcagagttc
      421 ccggtcattg tggagtcatt gaaatgtctt tgtaacatcg tgttcaacag tcaggtggca
      481 cagcagctta gcctggaact gaatctcgct gcaaagctct gtaacctcct gaggaagtgc
      541 aaggaccgaa aatttatcaa tgacataaag tgctttgacc tgcgcttgct ctttgtcctg
      601 tcacttttgc acactgacat caggtcacaa ttgcgctatg agctccaggg actgccgctg
      661 ctaacccaga tcttggaaag tgcctttagc atcaagtgga ccgatgagta tgagtcggcc
      721 atagaccata gtggacctcc tctctcacct caggagacag actgtgccat tgaggccctc
      781 aaagctctgt tcaatgtgac ggtagacagt tggaaggtgc ataaagagag cgattctcat
      841 cagttccgtg tcatggccgc tgtccttcgc cactgtttac taattgtagg tccaaccgaa
      901 gacaaaacgg aagagctgca cagtaatgcc gtcaaccttt taagcaatgt tccagtctct
      961 tgtttggatg ttctcatttg tccattaacc catgaagaaa cagcccagga ggcagcaact
     1021 ctagacgaac tgcccggtga taagacagca gagaaagaca cggctttgaa gagcagtgcc
     1081 atggtataca atggcatgaa catggaggcc atccacgttt tactcagttt tatggagaag
     1141 aggattgata agggaagcag ctatagagag ggtctaactc cagttctcag cttattaaca
     1201 gaatgttccc gagcccatcg gaacatccga aaatttctca aagatcaggt gttaccacct
     1261 ttgagggatg tgacaaatcg accagaagtc ggctcaaccg tgagaaataa gctggtgcgc
     1321 ctcatgacac acgttgacct cggagtcaag cagattgctg ctgagttcct cttcgtcctt
     1381 tgcaaagagc gagtggatag tctgctgaag tacactggct atgggaacgc tgcaggactg
     1441 ctggctgcca ggggcctctt ggctggagga agaggagaca attggtactc agaggacgag
     1501 gacacggaca ctgaggaata caaaaacgca aaaccaaaca ttaatcttat cactggtcat
     1561 ttagaggaac caatgccaaa ccctatagat gaaatgacag aagaacaaaa agaatatgaa
     1621 gccatgaaac ttgtcaacat gcttgataaa ctctccagag aggagttgct taaaccaatg
     1681 ggactaaaac ctgacgggac aataacgcct ttggaggaag cgctcagcca gtattctgtc
     1741 atcgaagaga ccagctcgga cacagactga aagcgccgtc acctgctccc tctcaatatg
     1801 gcttttatca gcatcttttc tctgtagctc caggggaatc ttctctagaa cgtttatgcc
     1861 ctcgctttgg ctagaaacac attaactggt ttactcatcg ggaatccagc atatttaaga
     1921 ggtaatcctg tgttttctgc aacattgagg cattcgtaca gagctgcagt caggcagagt
     1981 tgcggggcta gaagcagaag ctgccatccc attgcaccag gacggaggat gggacttcac
     2041 ttggcaaagc agccctggtc aaatctggca gtcctattgc cgggaattcc tagccgaaga
     2101 ttcggccgtg tccttccacc catcgtataa accgcccctc tgagtctctc cagcgaccca
     2161 aggcacagga gagtccgagg agctgctaaa caagggctga ggcaagcaac tccttaggtc
     2221 agcgctgact gaatggaagc caggcagctg ctccgaaagc ctagccccac ccttcatttc
     2281 agttttatac aaatgtggaa acacacacat acacgcacgc atacgcgcgc gcgcgcgcac
     2341 acacacacac acacacacac acacacacac acacacacac acacacacac acacacacac
     2401 acacacacac ggccccagac ttacaaacct attaagctct cacagttggt tacttagcta
     2461 acacttgaga ttacatttct ccctaggagg agttagcagt gatgggttag ttcaggcagc
     2521 tccacgtgcc tatttacccc tcgatcctga acactactag aaccgtaggg ctggaccaca
     2581 cctgtaccgc tgcgtccaca gcgtgcattc tgagatacca ctcagggtgc caagttcaca
     2641 ctcatcctca ggcaacagag aggatggggc tccccgagta gtgggagttc ttttgtggcc
     2701 tgtgctgggg cagggagcca acagcaccca tttgtacata caggtcattc gtgtgtcaca
     2761 tgttctaaac aggggtctct gtgtgtattt gtgtgtgtgt tctacctttc taccatatgt
     2821 gatcagttta atggtaactt tatttattta aaaaaaaaga aacacagata gttactattg
     2881 aactgattaa ggctgtgtat ttgtactcct aggaatggtc atatgaagta gatgtgcaat
     2941 catgtagaca gcaggccaag gtgatcagtg gctaaggttg gaaaggggtt ggtttctctc
     3001 atatatgtat gtatgtgtgt gtagatgcgc atacataggt atatgcacac atagattatg
     3061 tgcttggcca ctgcctttta aaactttaaa ttaaataaaa cgttggggat gattcaattt
     3121 a
//
LOCUS       NM_001437939            1539 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 126 (Rnf126), transcript
            variant 1, mRNA.
ACCESSION   NM_001437939 XM_006240899
VERSION     NM_001437939.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Huang,C.Y., Lee,F.L., Peng,S.F., Lin,K.H., Chen,R.J., Ho,T.J.,
            Tsai,F.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain
            IGF-IIR expression for hypertension-induced cardiomyocyte
            hypertrophy
  JOURNAL   J Cell Physiol 233 (2), 979-989 (2018)
   PUBMED   28383811
  REMARK    GeneRIF: Angiotensin II activates ERK/GSK3 to phosphorylate HSF1,
            resulting in RNF126 degradation, which stabilizes IGF-IIR protein
            expression and eventually results in cardiac hypertrophy.
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Rodrigo-Brenni,M.C., Gutierrez,E. and Hegde,R.S.
  TITLE     Cytosolic quality control of mislocalized proteins requires RNF126
            recruitment to Bag6
  JOURNAL   Mol Cell 55 (2), 227-237 (2014)
   PUBMED   24981174
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Smith,C.J. and McGlade,C.J.
  TITLE     The ubiquitin ligase RNF126 regulates the retrograde sorting of the
            cation-independent mannose 6-phosphate receptor
  JOURNAL   Exp Cell Res 320 (2), 219-232 (2014)
   PUBMED   24275455
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Delker,R.K., Zhou,Y., Strikoudis,A., Stebbins,C.E. and
            Papavasiliou,F.N.
  TITLE     Solubility-based genetic screen identifies RING finger protein 126
            as an E3 ligase for activation-induced cytidine deaminase
  JOURNAL   Proc Natl Acad Sci U S A 110 (3), 1029-1034 (2013)
   PUBMED   23277564
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Zhi,X., Zhao,D., Wang,Z., Zhou,Z., Wang,C., Chen,W., Liu,R. and
            Chen,C.
  TITLE     E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by
            targeting the tumor suppressor p21 for ubiquitin-mediated
            degradation
  JOURNAL   Cancer Res 73 (1), 385-394 (2013)
   PUBMED   23026136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006240899.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.24474.1,
                                           SRR26643285.26715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000007.1  10590071-10590205
            136-194             JAXUCZ010000007.1  10594365-10594423
            195-258             JAXUCZ010000007.1  10594526-10594589
            259-503             JAXUCZ010000007.1  10594736-10594980
            504-572             JAXUCZ010000007.1  10595420-10595488
            573-642             JAXUCZ010000007.1  10595554-10595623
            643-736             JAXUCZ010000007.1  10595873-10595966
            737-852             JAXUCZ010000007.1  10596049-10596164
            853-1539            JAXUCZ010000007.1  10596899-10597585
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1539
                     /gene="Rnf126"
                     /note="ring finger protein 126"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
     exon            1..135
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1002
                     /gene="Rnf126"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF126"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF126 isoform 1"
                     /protein_id="NP_001424868.1"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
                     /translation="MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEET
                     RNTENGSAPSTAPTDQNRQPFENVDQHLFTLPQGYSQFAFGIFDDSFEIPAFPPGAQA
                     DDGRDPESRREREHQSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIISP
                     AAVPSLGLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTV
                     PVTEEHVGSGLECPVCKEDYALGERVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLT
                     GQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS"
     misc_feature    88..180
                     /gene="Rnf126"
                     /note="zinc-ribbon; Region: zinc_ribbon_9; pfam14369"
                     /db_xref="CDD:433910"
     misc_feature    88..180
                     /gene="Rnf126"
                     /note="zinc-ribbon; Region: zinc_ribbon_9; pfam14369"
                     /db_xref="CDD:433910"
     misc_feature    748..879
                     /gene="Rnf126"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 126 (RNF126) and similar proteins; Region:
                     RING-H2_RNF126; cd16801"
                     /db_xref="CDD:438453"
     misc_feature    748..879
                     /gene="Rnf126"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 126 (RNF126) and similar proteins; Region:
                     RING-H2_RNF126; cd16801"
                     /db_xref="CDD:438453"
     exon            136..194
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            195..258
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            259..503
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            504..572
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            573..642
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            643..736
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            737..852
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1539
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaaacggc cggcggcagg cgccgcgcgg ggggcgggcg gcgcggaggc ggcggtggcc
       61 atggctgagg cgtcgccgca gcccggacgg tacttctgcc actgctgttc ggtggagatc
      121 gtgccgcgcc tgccggatta catctgccca cggtgcgagt ctggcttcat cgaggagctt
      181 ccagaagaga ccaggaacac agaaaacggc tcagccccct ccacagcccc tactgaccag
      241 aaccggcagc catttgagaa tgtggaccag cacctgttca cgctgccaca gggatacagc
      301 cagtttgctt ttggcatctt cgacgacagc tttgagattc ccgcgttccc tcctggggcc
      361 caggccgatg atggcaggga ccctgagagc cgacgggaga gagagcacca gtctcggcat
      421 cggtatgggg cccggcagcc ccgtgcccgc ctcactgccc ggcgggccac tggccggcat
      481 gaaggcgtcc ccacgctgga agggatcatc cagcagctcg tgaatggcat catctctcca
      541 gctgccgtac ccagcctggg ccttggtccc tggggcgtcc tgcactcgaa cccaatggac
      601 tacgcctggg gggccaacgg cctggacgcc atcatcacgc agctcctcaa tcagtttgag
      661 aacaccggcc ccccacctgc agacaaggag aagattcagg ctctccccac ggtcccagtc
      721 acagaggagc acgtgggctc agggctggag tgcccagtgt gcaaagaaga ctacgcgctg
      781 ggtgagagag tgcggcagtt accctgcaac cacctgttcc acgacagctg catcgtgccc
      841 tggctggagc agcatgacag ctgcccggtc tgccgcaaga gcctcactgg acagaacaca
      901 gccaccaatc ctccaggcct gaccggtgtt ggcttctcct cgtcctcgtc ctcatcctcg
      961 tccagctcac ccagcaacga gaacgccaca agcaactcct gagtcccacc tggccatccc
     1021 cccggggctt ggtcatccca cccaccccag gtgccccagc accgcctgcc atggccgtgg
     1081 actagaggtg ctgcccatgg cggccggcag cacctggcgg gccccaggct gcgggcggct
     1141 cggacttggc catggccgct cctgtttgga ggtgtgcacg tgggtcccat gtccccagca
     1201 ggcaggcgcc ttcagtccgt ctttaacctc accctccaaa tgttcaacgg cagaagggtt
     1261 tttatgattt taaattatta ctgctttgaa ataaatggac gtttgagcca cgtgcggcca
     1321 tgcatgatct gtggagagtc agcagaactg tcgccaggcc cagcccgcca catgccctgg
     1381 gaggccgggc cagcacccag tcagcgccgg cctcgggacc acgagggtga ccagcagacc
     1441 caggaacaaa ctgctccagc agacattttt tttttttttt ttaagggaaa tgtgtgttat
     1501 ctggaaagct atttaaaata cacctactca aaaagcaga
//
LOCUS       NM_001437982            2807 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus MGAT4 family, member C (Mgat4c), transcript
            variant 2, mRNA.
ACCESSION   NM_001437982 XM_017594737
VERSION     NM_001437982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_017594737.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.833008.1,
                                           SRR26360176.2206032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000007.1  38596117-38596438
            323-361             JAXUCZ010000007.1  38773290-38773328
            362-470             JAXUCZ010000007.1  38970909-38971017
            471-520             JAXUCZ010000007.1  39323164-39323213
            521-673             JAXUCZ010000007.1  39346115-39346267
            674-821             JAXUCZ010000007.1  39354954-39355101
            822-2807            JAXUCZ010000007.1  39359103-39361088
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..2807
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="MGAT4 family, member C"
                     /db_xref="GeneID:299756"
                     /db_xref="RGD:1307871"
     exon            1..322
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            323..361
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            362..470
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            471..520
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    479..481
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="upstream in-frame stop codon"
     exon            521..673
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..1963
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /EC_number="2.4.1.145"
                     /note="isoform 2 is encoded by transcript variant 2;
                     alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase C; mannosyl
                     (alpha-1,3-)-glycoprotein
                     beta-1,4-N-acetylglucosaminyltransferase, isozyme C
                     (putative)"
                     /codon_start=1
                     /product="alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase C isoform 2"
                     /protein_id="NP_001424911.1"
                     /db_xref="GeneID:299756"
                     /db_xref="RGD:1307871"
                     /translation="MFKFYQMKYIFQILDKMRCLRKRSTVSFLGVLVVFLLFMNVFIE
                     DSYVLEGDKQLIRETSTHQLNSERYVHTFKDLSNFSGTINVTYRYLAATPLQRKRYLT
                     IGLSSVKRKKGNYLLETIKSIFEQSSYEELKEISVVVHLADFNSSWRDAMVQDITQKF
                     AHHIIAGRLMVIHAPEEYYPVLDGLKRNYNDPEDRVRFRSKQNVDYAFLLNFCANTSD
                     YYVMLEDDVRCSRNFLTAIKKVIASLEGTYWVTLEFSKLGYIGKLYHSHDLPRLAHFL
                     LMFYQEMPCDWLLTHFRGLLAQKNVIRFKPSLFQHMGYYSSYKGTENKLKDDDFEEES
                     FDIPDNPPASLYTNMNVFENYEASKAYSSVDEYFWGKPPSTGDTFVIVFENPIKIKKI
                     KVNTGTEDRQNDILHHGALDVGEKLIFSKQIRQCETYLRLGEFKNGNFEMSDVNQKIP
                     FDIHCMRICVTKTQKEWLIIRSISIWTS"
     misc_feature    716..1516
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="N-Acetylglucosaminyltransferase-IV (GnT-IV)
                     conserved region; Region: Glyco_transf_54; pfam04666"
                     /db_xref="CDD:461384"
     misc_feature    716..1516
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /note="N-Acetylglucosaminyltransferase-IV (GnT-IV)
                     conserved region; Region: Glyco_transf_54; pfam04666"
                     /db_xref="CDD:461384"
     exon            674..821
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
     exon            822..2807
                     /gene="Mgat4c"
                     /gene_synonym="RGD1307871"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgcagactg cagatgagag agtctggagc agagacagtt ttaacttagc cattcctaat
       61 ttatctcaag cgttttcaat tcatcttcac tgctctgtgc acacaggaac agcagattgc
      121 catccctggg gaacaaaacg caaccgggga tctagagagc tgtcacattc caagaaatat
      181 ttaaattgtg ctggttttct tctggagagc tgagcccagg gaatgaaaac tctccatcca
      241 gtcgtagctt tgcgggcaat agatcagagg atattgccag gctcctaatg gattattgtt
      301 atcgggcagg ttttctctga agagtcctga tgtctcccag atcctaggct aatatccaaa
      361 gggattggag gtcagatcag ttgtacgcac aaagccactt tggatctgtc tccaaaacgg
      421 gaactccctt cacagaatgc cacaacaagg ttgaagcaac agtccgtctg ggtgacaata
      481 gcttttatac aggacagatt atgtcagctt ctttcttaag gagaggatgt ttaaatttta
      541 tcaaatgaaa tatatttttc aaatattgga taaaatgaga tgcttgcgaa aacgttctac
      601 agtgtcattc ttgggagtcc ttgttgtttt tcttctattc atgaatgtgt tcattgaaga
      661 tagctatgtt ctggaaggcg acaagcaact tataagggaa acatcaacac atcaacttaa
      721 ttctgaacgc tatgttcata ccttcaagga tttatcaaac ttctcaggaa ctataaatgt
      781 cacctatcgc tacctggctg ccacaccttt acagagaaag cgatatctca caattggact
      841 ttcatcagta aaacggaaaa aaggaaatta tttacttgag acaatcaagt caatttttga
      901 acagtccagc tatgaagaac taaaagaaat ttcagttgta gtgcatctag cagactttaa
      961 ttcatcatgg cgtgatgcca tggtccaaga tattacacag aaatttgccc atcatattat
     1021 tgcaggaaga ttaatggtta tacatgctcc tgaagaatat tatccagttc tggatggtct
     1081 taaaagaaat tacaatgacc cagaagatag agtcagattt cgctccaagc aaaatgtaga
     1141 ttatgctttt ctgctaaatt tctgtgccaa tacttctgac tattatgtaa tgcttgaaga
     1201 tgatgtccgg tgttccagaa atttcttaac tgccatcaag aaagttatcg catccttaga
     1261 aggaacatac tgggtaactc ttgagttctc taaacttggc tacattggaa aactctatca
     1321 ttctcatgat ctcccacgtc tggcccattt cttattaatg ttttatcaag aaatgccttg
     1381 tgactggcta ttgactcatt tccgagggct gctggctcag aaaaatgtga ttcgatttaa
     1441 accttctctc tttcagcaca tggggtatta ttcatcctat aaaggaacgg agaataaact
     1501 gaaggatgat gactttgaag aggagtcatt tgacatccct gataacccac cagcaagtct
     1561 ctacaccaac atgaatgtct ttgaaaatta cgaagcaagc aaggcttaca gtagtgttga
     1621 tgagtacttt tggggaaagc caccttcaac gggggatacg tttgttattg tatttgagaa
     1681 tcctattaaa attaaaaaaa ttaaggtgaa tactggaaca gaagaccggc agaatgacat
     1741 tttgcatcac ggagccctag atgttgggga aaaactcatt tttagcaaac aaataagaca
     1801 atgtgaaact tacttaagac taggggaatt caaaaatgga aactttgaaa tgtcagatgt
     1861 gaatcaaaaa attccctttg acatacattg catgaggata tgtgtcacca aaactcagaa
     1921 agaatggttg ataattagga gcatcagcat ttggacttcc tagccaagta aatcagtaga
     1981 ttgagtttct gaaacaggtc ttcctgtttc aatttttgct attccctctt ttgctacttt
     2041 tgtcttttgg agggtaacta attggtgtgc tgtggcacaa gaacgttgag tcatctcagc
     2101 agttttgatt gtagttttac taagcacatc tttgtaatta atttcacgtt tcaggctgaa
     2161 tatcattctg tagttaaaac tgatttcact cattcattta aatgttcata gttccaaatt
     2221 tcaactcatt gtgcaaagag ttgataattt attttatgtt tagaaagatt cttagtaaga
     2281 atatatgaga atatgcagat tggttgccat cataaaatgg gatacttttt cttataaatt
     2341 taggctttca ctgactgatg tatttctaca attaatacct cctcatggaa gtggtgtctt
     2401 tacaacagat tagttgtgta agtagagctt tgaaaaaaca gacttaaaag tcatcattcc
     2461 tttggttatt tctatgaaaa ggaacattgc tcattgtttt aaaacattta attgagcaca
     2521 tgttaataca attcccatga gaataagtct atttctaatt tcccttttga aaatatatag
     2581 ttaagctcaa tattttaagg ttatattgga tatctgtaat taatagagga agagagatgg
     2641 cttaccgtta gttcattcat acattttcag tatatgtaga aaaaactgaa attgatgttt
     2701 ttactttttg tattaaaact catgtgatta aaattgttgt aatttatcat atttggggaa
     2761 gattaaatgg ctgtcttatg tgggagaaaa gtaaaattta aagtaac
//
LOCUS       NM_001437904            2733 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 2 (Amigo2),
            transcript variant 2, mRNA.
ACCESSION   NM_001437904 XM_063263369
VERSION     NM_001437904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Li,Z., Khan,M.M., Kuja-Panula,J., Wang,H., Chen,Y., Guo,D.,
            Chen,Z.J., Lahesmaa,R., Rauvala,H. and Tian,L.
  TITLE     AMIGO2 modulates T cell functions and its deficiency in mice
            ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   Brain Behav Immun 62, 110-123 (2017)
   PUBMED   28119027
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Kanda,Y., Osaki,M., Onuma,K., Sonoda,A., Kobayashi,M., Hamada,J.,
            Nicolson,G.L., Ochiya,T. and Okada,F.
  TITLE     Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to
            Liver Endothelial Cells Resulting in Liver Metastases
  JOURNAL   Sci Rep 7, 43567 (2017)
   PUBMED   28272394
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Park,H., Lee,S., Shrestha,P., Kim,J., Park,J.A., Ko,Y., Ban,Y.H.,
            Park,D.Y., Ha,S.J., Koh,G.Y., Hong,V.S., Mochizuki,N., Kim,Y.M.,
            Lee,W. and Kwon,Y.G.
  TITLE     AMIGO2, a novel membrane anchor of PDK1, controls cell survival and
            angiogenesis via Akt activation
  JOURNAL   J Cell Biol 211 (3), 619-637 (2015)
   PUBMED   26553931
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646. PMID: 39110596]
REFERENCE   5  (bases 1 to 2733)
  AUTHORS   Rabenau,K.E., O'Toole,J.M., Bassi,R., Kotanides,H., Witte,L.,
            Ludwig,D.L. and Pereira,D.S.
  TITLE     DEGA/AMIGO-2, a leucine-rich repeat family member, differentially
            expressed in human gastric adenocarcinoma: effects on ploidy,
            chromosomal stability, cell adhesion/migration and tumorigenicity
  JOURNAL   Oncogene 23 (29), 5056-5067 (2004)
   PUBMED   15107827
REFERENCE   6  (bases 1 to 2733)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   7  (bases 1 to 2733)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063263369.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.42069.1,
                                           SRR26643295.29981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840118 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000007.1  130273475-130273753 c
            280-2733            JAXUCZ010000007.1  130270639-130273092 c
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2733
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
     exon            1..279
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    227..229
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="upstream in-frame stop codon"
     exon            280..2733
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1900
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="amphoterin-induced protein 2; alivin 1; AMIGO-2;
                     amphoterin induced gene 2; transmembrane protein AMIGO2;
                     transmembrane protein AMIGO2-like"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_001424833.1"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
                     /translation="MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTAC
                     ICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHN
                     NITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAF
                     GGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQ
                     LRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQD
                     SFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDK
                     DTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHA
                     HEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPT
                     RDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSETVIAEGILKSSRAKSDSDSVN
                     SVFSDTPFVAST"
     sig_peptide     338..448
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     mat_peptide     449..1897
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /product="Amphoterin-induced protein 2.
                     /evidence=ECO:0000255. /id=PRO_0000014512"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1)"
     misc_feature    485..550
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    485..550
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    506..508
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    539..604
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 1"
     misc_feature    <542..>1024
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <542..>1024
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    551..619
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    551..619
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    614..679
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 2"
     misc_feature    623..688
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    623..688
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    644..646
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    686..751
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 3"
     misc_feature    689..760
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    689..760
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    758..823
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 4"
     misc_feature    761..832
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    761..832
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    830..895
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 5"
     misc_feature    833..913
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    833..913
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    911..976
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: LRR 6"
     misc_feature    992..1030
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    992..1030
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275378"
     misc_feature    1175..1177
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1196..1198
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1226..1438
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1226..1438
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Immunoglobulin domain; Region: ig; pfam00047"
                     /db_xref="CDD:395002"
     misc_feature    1250..1264
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1250..1264
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    1292..1306
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1292..1306
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1346..1360
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1346..1360
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1367..1369
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1412..1429
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1412..1429
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1451..1453
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1475..1477
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1484..1486
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1496..1498
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNJ4.1); glycosylation site"
     misc_feature    1532..1594
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     transmembrane region"
     misc_feature    1646..1711
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1829..1897
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      
        1 gggccctgca gcctgcgagc gccaccggcg ggccggcttt ccccgccgcc caccccgctc
       61 ccggcgcggc cgagctccgg cggtacctgc agccgagcca gagagccggg gagccctcgc
      121 cgccgcctcg aaactcgcca aagttgagag gctgccgccc accgggagct ggagggaagg
      181 tgcgagcgcg cggggcgcga accggcagac ggacgcgcgg accttctgag cgcaccgccg
      241 tcggcggcct ctcccgagcc gctgcggctt ccccgcgcta ttggtgggag gctgtgctgg
      301 tgagaagcga ctggcaagag gctcagaggc gaccataatg tcgttaaggt tccacacact
      361 gcccaccctg cctagagctg tcaaaccggg ttgcagagag ctgctgtgtc tgttggtgat
      421 cgcagtgatg gtgagcccca gctcctcagg actgtgccct acggcttgca tctgtgccac
      481 tgacattgta agctgcacca acaaaaacct gtctaaggtg cctgggaacc ttttccgact
      541 gattaaaaga ctggatctga gctataacag aatcggactc ctggatgccg actggattcc
      601 ggtgtcgttc gtcaagctga gcaccctgat tgttcgccac aacaacatca ccagcatttc
      661 cacgggcagc ttctccacca ctccaaattt aaagtgtctc gacttatcgt ccaataggct
      721 gaagtcggtg aaaagtgcca tgttccagga gctaaaggtt ctggaagtgc tcctgcttta
      781 caacaaccac atttcctatc tggacccggc agcgttcgga gggctctccc acttgcagaa
      841 actctacctg agtgggaact tcctcacgaa gttccctatg gatttgtatg tcgggaggtt
      901 caagctggct gatctgacat ttttagatgt ttcgtacaat caaattgctt ccataccaat
      961 gcaccacata aatttagtgc cgggaaagca gctgaggggc atcttccttc acgggaaccc
     1021 tttcgtctgt gactgttccc tgtactcctt gctgaccttc tggtaccgta ggcactttaa
     1081 ctctgtgacg gatttcaagc atgactacac ctgtcgcctg tggttggact ccaggcactc
     1141 ccaccagctg ttgctgctcc aggatagctt tctgaactgt tctcacagcg tcatcaacgg
     1201 ctccttccac gcacttggct ttatccacga ggctcaggtt ggggaaaggg cgattgtcca
     1261 ctgtgacggc aaaaccggta acgggaacac cgatttcatc tgggtgggtc ccgacaacag
     1321 gctgttggag ccggataaag acacggggaa ctttcgagtg ttttacaacg gaagcctggt
     1381 tatagagaac cctggttttg aggacgccgg ggtttactcc tgtatcgcca tgaacaggca
     1441 gcgcctgttg aatgagacgg tggacatcat gataaacgtg agcaatttca ccataaacag
     1501 atcccaccac gcccacgagg catttaacac ggctttcacc accctggctg cctgcgtggt
     1561 cagtatcgtc ctagtgctac tgtacctgta cctgacaccg tgtccctgca aatgtagaga
     1621 caagagacag aaaaacgcac tgaaccaaag caacgcccat tcgtccattc tcagtcccgg
     1681 ccccacccgg gatgcctctg ctgaggatcg gaaggcaggt aaaagagtgg tgtttttgga
     1741 gcccctgaag gatccagcgg tgggacagaa tggaaaagtc aagcttgtcc ccagtgagac
     1801 cgttatagcc gagggcatct taaagtcctc cagggcaaaa tctgactcag actcggtcaa
     1861 ttccgtgttc tcagacacac ccttcgtggc atccacttaa ccgtgtgcct gtgttcgtct
     1921 ggtgtcgtga tttgacctct ccctacccaa ctgcagtcca cgaaattagt agcaggagag
     1981 aaactgtttt gtctttttga gagaaaacca aatggtgtct ttatgatggt tgctaggaag
     2041 tgaggcagag caccctggtt gcttcctcgt gctgggtaaa gatccagttg attttgagag
     2101 tcttaagttc ccagtaacag ccatcagcat ctttgaggat ttcaggctgg cctgaaggcg
     2161 gtaggaccag ccattatctc ctggttatct cggagggaaa aaaaataaag ctatgtgtta
     2221 gcattcttta aaaatagaac cttttaactt actagagcca aagttgagct gagcttttct
     2281 tatttttaag aaaaacacga gtggcttctt tcccctctaa aagatgtaga aggaagaatc
     2341 ggttatttat agatcataaa gttagcatag aggtttttca gccgaaacca tcatttcgga
     2401 ccaggataga cacactagta acatccacag aatcatgcca cgtcccatgg agtgcacagg
     2461 ggcctagctt ttagctgtct tctccgtcat ctctgtgctg tatcctggta caaaagatgc
     2521 cccccaaaaa gttaaaggtg tctttatgtg ttgccaagag tatgtgtcac tgccaaactg
     2581 tctgagtcac tccctacacc ctcaccgcag cagactcagg tttgtccacc tgcgtgtgta
     2641 tatgtaaaac cttaagttct atgaatggcc gtatagaccc caatgtactg tattccagac
     2701 atttaaatca gcgtaaatac acgtgctctg tga
//
LOCUS       NM_001437911            3796 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus ubiquitin associated protein 2-like (Ubap2l),
            transcript variant 5, mRNA.
ACCESSION   NM_001437911 XM_063282151
VERSION     NM_001437911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Bordeleau,M.E., Aucagne,R., Chagraoui,J., Girard,S., Mayotte,N.,
            Bonneil,E., Thibault,P., Pabst,C., Bergeron,A., Barabe,F.,
            Hebert,J., Sauvageau,M., Boutonnet,C., Meloche,S. and Sauvageau,G.
  TITLE     UBAP2L is a novel BMI1-interacting protein essential for
            hematopoietic stem cell activity
  JOURNAL   Blood 124 (15), 2362-2369 (2014)
   PUBMED   25185265
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063282151.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.8338.1,
                                           SRR26643295.9799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000002.1  177791620-177791637 c
            19-148              JAXUCZ010000002.1  177786942-177787071 c
            149-226             JAXUCZ010000002.1  177784108-177784185 c
            227-337             JAXUCZ010000002.1  177782701-177782811 c
            338-506             JAXUCZ010000002.1  177779310-177779478 c
            507-602             JAXUCZ010000002.1  177778834-177778929 c
            603-648             JAXUCZ010000002.1  177775282-177775327 c
            649-761             JAXUCZ010000002.1  177774722-177774834 c
            762-814             JAXUCZ010000002.1  177768704-177768756 c
            815-900             JAXUCZ010000002.1  177766872-177766957 c
            901-1072            JAXUCZ010000002.1  177765163-177765334 c
            1073-1271           JAXUCZ010000002.1  177760418-177760616 c
            1272-1549           JAXUCZ010000002.1  177758391-177758668 c
            1550-1722           JAXUCZ010000002.1  177758048-177758220 c
            1723-1912           JAXUCZ010000002.1  177756072-177756261 c
            1913-1967           JAXUCZ010000002.1  177755325-177755379 c
            1968-2142           JAXUCZ010000002.1  177753749-177753923 c
            2143-2215           JAXUCZ010000002.1  177753274-177753346 c
            2216-2411           JAXUCZ010000002.1  177751968-177752163 c
            2412-2500           JAXUCZ010000002.1  177751792-177751880 c
            2501-2554           JAXUCZ010000002.1  177749533-177749586 c
            2555-2636           JAXUCZ010000002.1  177747255-177747336 c
            2637-2854           JAXUCZ010000002.1  177746302-177746519 c
            2855-2960           JAXUCZ010000002.1  177745433-177745538 c
            2961-3028           JAXUCZ010000002.1  177740434-177740501 c
            3029-3226           JAXUCZ010000002.1  177739078-177739275 c
            3227-3796           JAXUCZ010000002.1  177737223-177737792 c
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3796
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="ubiquitin associated protein 2-like"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
     exon            1..18
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            19..148
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="upstream in-frame stop codon"
     CDS             59..3322
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     Atpase, class I, type 8B, member 2"
                     /codon_start=1
                     /product="ubiquitin-associated protein 2-like isoform 5"
                     /protein_id="NP_001424840.1"
                     /db_xref="GeneID:361984"
                     /db_xref="RGD:1308707"
                     /translation="MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISD
                     HNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKK
                     KGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGT
                     KSGGPSGRGTDRGRRGRGRGRGSSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGSSS
                     GNTWNNTGHFEPDDGTSAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTI
                     TAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPSLAQPLVFSNSKQNAISQPASGNTFS
                     HHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQALAQLAAQHSQSGSTTTSSWDM
                     GSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFTPSSTMMEVFLQEKPPAVATSTAAPP
                     PPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQKKKTSLTSKIPALAVEMPGS
                     ADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAPSSLYTSTASESSSTVSSNQS
                     QESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPSSISSSPQKDLTQAKNGFSSV
                     QATQLQTTQSVEGATGSAVKSESPSTSSIPSLNETVPAASLLTTASQHSSSLSGLSHS
                     EEIPNTTTTQHSSALSTQQNTLSSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTS
                     STVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPL
                     LPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPTPTTPLTGRDGSLASN
                     PYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSYTSLPYY
                     TGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVT
                     SSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPA
                     PFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    206..319
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="UBA domain found in ubiquitin-associated protein 2
                     (UBAP-2) like proteins; Region: UBA_UBP2_like; cd14277"
                     /db_xref="CDD:270463"
     misc_feature    1544..1627
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     misc_feature    1544..1627
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /note="Ubiquitin-associated protein 2; Region: DUF3697;
                     pfam12478"
                     /db_xref="CDD:372135"
     exon            149..226
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..337
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..506
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..602
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..648
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..761
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..814
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..900
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1072
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1271
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1549
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1722
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1912
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1967
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2142
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2215
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2411
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2500
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2554
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2636
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2854
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2960
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3028
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3226
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3796
                     /gene="Ubap2l"
                     /gene_synonym="Atp8b2; EP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggagg agactgagta ttcttccttg taaatactgt tatttgtata tactgtaaat
       61 gatgacgtcg gtgggcacta accgagcccg gggaaactgg gaacaacctc aaaaccaaaa
      121 ccagacacag cacaagcagc ggccacaggc cactgcagag caaattcgac ttgcacagat
      181 gatttcggac cataatgatg ctgactttga ggagaaggtg aaacaattga ttgatatcac
      241 aggcaaaaac caggatgaat gtgtgattgc tttgcatgac tgcaatggag atgtcaacag
      301 agccatcaat gttctcctgg aaggaaatcc agacacgcat tcctgggaga tggtcgggaa
      361 gaagaaagga gtctcaggac agaaggatgg tggacaaact gaatctaatg aagaaggaaa
      421 agaaaatcga gaccgggaca gagactatag tcgacgacgt ggtgggccac caagacgggg
      481 gagaggtgcc agccgtggac gagagtttcg gggccaggaa aatggattgg atggcactaa
      541 gagtggtgga ccttctggaa gaggcacaga cagagggaga agaggccgtg gccggggcag
      601 aggtagttct ggtagacgag gaggaaggtt ttctgctcaa ggaatgggaa cctttaaccc
      661 tgctgattat gcagagccag ccaacactga tgataactat ggcagtagca gtggcaatac
      721 atggaacaac actggccact ttgaaccaga tgatggaaca agtgcatgga ggactgcaac
      781 agaagagtgg ggaactgaag attggaatga agatctttct gagaccaaga tctttactgc
      841 ctctaatgtg tcttcagtgc ctctgcctgc ggagaatgtg acaatcactg ctggtcagag
      901 aattgatctt gctgttctgt tggggaagac accgtcttca atggagaatg attcatctaa
      961 tctggatcca tctcaggctc cttccctggc ccagcctctg gtattcagta attcgaagca
     1021 gaatgccata tcacagcctg cttcagggaa tacattttct catcatagca tggtgagcat
     1081 gttggggaaa ggatttggtg atgttgggga agctaaaggt ggcagtacaa caggctctca
     1141 gttcttggag caattcaaga ctgcacaggc cctggctcaa ctggcagctc aacattctca
     1201 gtctggaagc accaccacct cctcttggga tatgggctca acaacacaat caccatcact
     1261 ggtgcagtat gatttgaaga gtgcaaatga ttcaacagtg cacagtcctt ttacaaagcg
     1321 ccaggcattc accccatcat caaccatgat ggaggtgttc cttcaggaga agccacctgc
     1381 agtggctacc tcgacagctg cacctcctcc cccctcttct cctctgccaa gcaaatccac
     1441 ctcggctcca cagatgtctc cggggtcttc ggacaaccaa tcctccagcc ctcagccggc
     1501 tcaacagaaa ctgaaacagc aaaagaagaa aacctccttg acgtctaaga ttcctgctct
     1561 ggctgtggag atgcctggct cagcagatat ctcagggcta aatctgcagt ttggggcatt
     1621 gcaatttggg tcagagcctg tcctttctga ttatgagtcc acccccacca cgagcgcctc
     1681 ttcaagccag gctcccagta gcctgtatac cagcacggcc agtgagtctt catctacagt
     1741 ttcatctaat cagagtcagg agtctggtta tcagagtggc ccaattcagt cgacaactta
     1801 tacctcccaa aataatgctc agggccctct atatgaacag agatccacac agacacggcg
     1861 gtatcccagc tccatctctt catcacccca aaaggacctg actcaggcta agaatggttt
     1921 cagctctgtg caggccacgc agttacagac cacgcaatct gttgaaggtg ctacaggctc
     1981 tgcagtgaaa tctgaatcac cttccacttc tagtataccc tctctcaatg aaacagtacc
     2041 tgcagcttcc ttactgacga cagccagtca gcattcatcc tccttaagtg gcttgagcca
     2101 tagtgaggag attccaaata ccaccaccac acaacatagc agtgcattat ctacacagca
     2161 gaataccctt tcttcatcaa catcttctgg gcgtacttca acatctactc ttttgcatac
     2221 aagtgtggag agtgaagcga atctgcattc ttcctccagc actttctcta ccacgtccag
     2281 cactgtctct gcacctcccc cagtggtcag tgtctcctcc agtctgaata gtggcagtag
     2341 cctgggcctt agcctgggca gcaactctac tgtcacagcc tcaactcgaa gctcagttgc
     2401 tacaacttca ggaaaagctc ctcccaacct tcctcctgga gtcccgccat tgttgcctaa
     2461 tccatatatt atggctccag ggctgttaca tgcctacccg ccacaagtat atggttatga
     2521 tgatttacag atgctccaga caagatttcc attggattac tacagtatcc cgtttcccac
     2581 acccaccact ccacttactg ggagggatgg tagcctggcc agcaaccctt actctggcga
     2641 cctcaccaag ttcggccgcg gggatgcctc ctccccagcc ccagccacaa ccttggccca
     2701 accccaacag aaccagacgc agactcacca caccacgcag cagacattcc tgaacccggc
     2761 gctgcctcct ggctatagtt acaccagcct gccatactac acaggggtcc cgggcctccc
     2821 cagcaccttc cagtatgggc ctgctgtgtt ccctgtggct cctacctctt ccaagcagca
     2881 tggtgtgaat gtcagtgtga atgcctcggc cacccctttc caacaaccaa gtggatatgg
     2941 gtctcatgga tacaacactg gtgtgtcagt cacctccagt aacacgggcg tgccagatat
     3001 ctcgggttct gtgtactcca aaacccagca gtcctttgag aaacaaggtt ttcattccgg
     3061 tactcctgct gcctccttca acttgccttc agccctagga agtggagggc ccatcaatcc
     3121 agccacagct gctgcctacc cacctgcccc ctttatgcac attctgaccc cacatcagca
     3181 gccacactct cagatccttc accatcacct gcagcaggat ggccagacgg gcagcgggca
     3241 acgtagccag accagctcca tcccgcagaa gccccagacc aacaagtctg cctacaacag
     3301 ctacagctgg ggggccaact gaggccctga ccctcttctc ctgtcccatc ttctgagagg
     3361 gcttctcagc ctggaaacta tggaaacagc atcaaagaga gaaaagaatg tggggcgatt
     3421 ccgctgctcc acacccccag cggcccatcc cacacctcag cttcatgtct gtcccatccc
     3481 tctaccatcc taccctgttg tatgtattat aggatttgta ttttcttccc tcccctcctc
     3541 ttcctccttt ctctttgcat tcaagattat gaaactttgc tgtgggccct gcctttccct
     3601 cacttcttcc tgttcaccct ggtggtgtat gggtgaggtg ggaaggtgaa acccctcccc
     3661 caccccaaat atatatcagc ccaacagccc taagtctcct cctttattat taggaaagcc
     3721 aaaccacaca cacacacaca cacacacaca cacacactaa aaaaaaatgg cgtcataaat
     3781 atgaacagca ttgtca
//
LOCUS       NM_001438009            3882 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 2, mRNA.
ACCESSION   NM_001438009 XM_006237878
VERSION     NM_001438009.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_006237878.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18284.1,
                                           SRR26643299.21990.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000005.1  29278875-29279380   c
            507-635             JAXUCZ010000005.1  29278248-29278376   c
            636-749             JAXUCZ010000005.1  29276909-29277022   c
            750-864             JAXUCZ010000005.1  29272117-29272231   c
            865-963             JAXUCZ010000005.1  29259227-29259325   c
            964-1018            JAXUCZ010000005.1  29259048-29259102   c
            1019-1129           JAXUCZ010000005.1  29257470-29257580   c
            1130-1262           JAXUCZ010000005.1  29257227-29257359   c
            1263-1305           JAXUCZ010000005.1  29257087-29257129   c
            1306-1607           JAXUCZ010000005.1  29253546-29253847   c
            1608-1826           JAXUCZ010000005.1  29252420-29252638   c
            1827-2025           JAXUCZ010000005.1  29250290-29250488   c
            2026-2194           JAXUCZ010000005.1  29246768-29246936   c
            2195-2345           JAXUCZ010000005.1  29237174-29237324   c
            2346-3882           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3882
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..506
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     CDS             375..2366
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     2"
                     /protein_id="NP_001424938.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKT
                     ELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVI
                     PTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANL
                     SSVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQCLKDAW"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    2001..2003
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); phosphorylation site"
     misc_feature    2118..2120
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); methylation site"
     misc_feature    2271..>2357
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    2271..>2357
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     exon            507..635
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            750..864
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1018
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1129
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1262
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1305
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1607
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1826
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2025
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2194
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..3882
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggga aaaggggcgg gcaggtagag ccacatccca aaacagaaaa gctttcagcc
       61 attgcgcgcg cctcccgggg gtgcagcccg gctcctgggg tttttttttc ttagacgcac
      121 gagcaattgg atacaaaaag ggcaggcctg ctgctccctc cttccacccc cccttcctgc
      181 ccagggtgtg gagcgccggc caggtgcggg cttgggtggc aggttaccgc cttttgccct
      241 ggcggcctcg aggagggggg tgggcgcttt ctttttctct tggaagaggg ttttagcaca
      301 ggttttctcg ttctcacttc caaccccacc tcgccgcctc ccgacccccc tcctcccctt
      361 ccccacctat cgtcatgacg gcgtctccgg attacttggt ggtgcttttt gggatcactg
      421 ctggggccac aggagccaag ctgggttcgg atgagaagga gctgatcctg ctgttatgga
      481 aagtcgtgga tttggccaac aagaaggtgg gacagttgca cgaagtacta gttagaccgg
      541 atcagttgga actgacagag gattgtaaag aagaaactaa aatagacgcc gaaaatctgt
      601 cttccgcccc gcagctggac caagccctcc gacagtttaa ccagtcagtg agcaatgaac
      661 tgaacattgg ggtagggact tccttctgtc tgtgtactga cgggcagctt cacgtcaggc
      721 agatcttgca tcccgaggct tccaagaaga atgtattact acctgaatgc ttctattcct
      781 ttttcgatct tcgaaaagaa ttcaagaagt gttgccccgg ctctcctgac ctcgacaagc
      841 tggatgttgc agccatggca gagagcctaa actttgagaa gaatgactcc atgtccagat
      901 acggagcctc ccaagttgaa gacatgggga acataatttt agcgatgatc tcagagccct
      961 acaatcacag attttcagat ccagagagag taaactacaa atttgaaagt ggcacttgca
     1021 gcaagacgga gcttatcgat ggcaacacgg tggtgagggc tcgaggtttg ccctggcagt
     1081 cttcagatca agatattgca aggttcttca aaggactcaa tattgccaag ggtggtgcag
     1141 ctctttgtct gaatgctcag gggcggagga acggggaagc tctggttaga tttgtaagtg
     1201 aggagcacag agatctggcc ctgcagaggc acaaacatca tatggggacc cgttacatcg
     1261 aggtttacaa agcaacaggc gaagactttc ttaaaattgc cggagggaca tccaatgagg
     1321 tggcccagtt tctctccaag gaaaaccaag tcatcgtgcg catgcggggg ctccctttca
     1381 cagccacggc ggaagaagtg gtagccttct ttggacagca ctgccctatc actgggggga
     1441 aggaaggcat cctcttcgtc acctacccag atggtaggcc cacgggagat gcttttgtgc
     1501 tctttgcttg tgaggagtat gctcagaacg ccctgaggaa gcacaaggac ttgttgggta
     1561 aaagatacat cgagctcttc agaagcacag cagctgaagt tcagcaggtg ctgaatcggt
     1621 tctcctccgc tcctttgatt ccacttccca ccgctcccat catccctgtg ctacctcagc
     1681 agtttgtgcc ccccacaaat gtaagagact gcgtacgtct gcgaggtctt ccctatgccg
     1741 ccaccataga agacattctg gacttcctgg gggagttttc cacagacatt cgtacgcatg
     1801 gggttcacat ggtattgaac caccagggac gcccgtcagg agatgccttt atccagatga
     1861 agtctacaga cagagcattc atggctgcgc agaagtatca taaaaaaacc atgaaggaca
     1921 gatatgttga agtctttcag tgttcagctg aggagatgaa ctttgtgtta atggggggca
     1981 ctttaaatcg aaatggctta tccccaccgc catgtaagtt accatgcctg tctcctccct
     2041 cctacacatt cccagctcct gcagccgtga ttcctaccga agctgccatt tatcagcctt
     2101 ccctgctctt gaacccacgg gcactgcagc cctccactgc ttactaccca gcaggcactc
     2161 agctgttcat gaactacaca gcctactatc ccagcccccc aggttcgcct aatagtcttg
     2221 gctacttccc tacagctgct aatcttagca gtgtcccgcc ccagcctggc acggtggtca
     2281 gaatgcaggg cctggcctac aatactggag ttaaggaaat tcttaacttc ttccaaggtt
     2341 accagtgttt gaaagacgca tggtgatcct gaaactatca gacgagaact tctagcaatt
     2401 tcaggggatg tttgtctaca ctcaggctgc ggaagtttca gccaacggat tggacagtgg
     2461 gcctgggcct tatcttttgg tggagtgaaa aaacgtggag ccgtggaagc caaatcttta
     2521 tagcaagcag tgtgcacgaa cctggctcct tgctgagtgc aaataggaat ttaaatgtga
     2581 atttgaagtc aaagttctca cttccagcta actggcaaca tttatttcct gagctgaagt
     2641 cttggagtaa aatacattcc agtagcatct accatccacc attaattgct atggaagcct
     2701 cattgtgtac cccactcttc tgtctccctg ttttctgtaa aataaaaccc tcttgctaag
     2761 taatttaagt gtacgttctt agaatactta agtcccaaac taaagaaaag gaataaaata
     2821 aaattaatat tttcccaaat actagttttc ttcaataggc catcatggtg ccttattgtt
     2881 aacaacaaat atttctaaaa tgtctcaggc aggctgggcc catctccgtg gtaaagagct
     2941 tgcctgccta gcacacttga gccctgggtt tgcagaccta tcccctgtgt cctctccaca
     3001 gtgcgccctt ccacacgcgc cttgttaaag gccttgctgc gtgtttttct ctgcaggtat
     3061 ccgctgtaaa taagaatgaa gtaggggcca aaacctgaaa ccaaaaatga agcagctcct
     3121 tgtagtctta gttcctagtt tgagctgtag ctgactgctt ggcttcccgt gtattatttt
     3181 atattgtgct tttgtcattg ttaatggttt ggactttaat aagagaaatc ccatagtttt
     3241 taatgtcaca aaaataagcc tatttgaaca gtgtattcca gaaagcaata tactaaccaa
     3301 agtgaatgct tgtgtgtatt gatacccttt tcctctctaa cgcctcaact gtcaaggaac
     3361 taaaaccttt aaaagcatag gcatgctggc ctgaggtaaa cactggtaca gttagagcgg
     3421 aggcagcagc ccccggtgtt cagcacagct tgtctgatgt gtttatggcc agagtgcagt
     3481 attcggcact ggctagtacc gctgcctgac cgaactccac tgggaagtgg tttgcttaaa
     3541 cgcacatgtt tctttgttac tcctgaccat gcttggatgc agtgcctaga ttgtggctgc
     3601 tatttttagt tcgcatcatg accttgactg cggagtccag ccttaccctc ttacttgaca
     3661 acagtagccc ttaaactgca gtgggaagaa agaagaattt ggtatgaaaa ttggtgagct
     3721 ctggcacttg agataaacaa gaagaaagtt ccaacttgat gccttaagcc gctcctgccc
     3781 gaagctctga aggactaagt tggcagagat ccttactttg atactactgc attttttgta
     3841 gaattgttac attgataata aaacttgcct gcttaacctc aa
//
LOCUS       NM_001438015            4416 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a),
            transcript variant 1, mRNA.
ACCESSION   NM_001438015
VERSION     NM_001438015.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Hu,Y., Hong,X.Y., Yang,X.F., Ma,R.H., Wang,X., Zhang,J.F., Feng,Q.,
            Li,X.G., Sun,D.S., Li,X., Wan,H.L., Li,T., Wang,Q., Ke,D.,
            Wang,J.Z. and Liu,G.P.
  TITLE     Inflammation-dependent ISG15 upregulation mediates MIA-induced
            dendrite damages and depression by disrupting NEDD4/Rap2A signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1477-1489 (2019)
   PUBMED   30826466
  REMARK    GeneRIF: The data revealed that maternal immune activation impedes
            offspring's dendrite development and causes depressive like
            behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A
            signaling.
REFERENCE   2  (bases 1 to 4416)
  AUTHORS   Emery,A.C., Xu,W., Eiden,M.V. and Eiden,L.E.
  TITLE     Guanine nucleotide exchange factor Epac2-dependent activation of
            the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest
            in neuroendocrine cells
  JOURNAL   J Biol Chem 292 (29), 12220-12231 (2017)
   PUBMED   28546426
  REMARK    GeneRIF: Data suggest that Rap2A is the obligate effector for Epac2
            in mediating growth arrest and reversal of neurite extension
            through activation of MAP kinase signaling via protein
            phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS
            oncogene family member Rap2A; Epac2 = guanine nucleotide exchange
            factor Epac2)
REFERENCE   3  (bases 1 to 4416)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   4  (bases 1 to 4416)
  AUTHORS   Kawabe,H., Neeb,A., Dimova,K., Young,S.M. Jr., Takeda,M.,
            Katsurabayashi,S., Mitkovski,M., Malakhova,O.A., Zhang,D.E.,
            Umikawa,M., Kariya,K., Goebbels,S., Nave,K.A., Rosenmund,C.,
            Jahn,O., Rhee,J. and Brose,N.
  TITLE     Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls
            neurite development
  JOURNAL   Neuron 65 (3), 358-372 (2010)
   PUBMED   20159449
REFERENCE   5  (bases 1 to 4416)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   6  (bases 1 to 4416)
  AUTHORS   Taira,K., Umikawa,M., Takei,K., Myagmar,B.E., Shinzato,M.,
            Machida,N., Uezato,H., Nonaka,S. and Kariya,K.
  TITLE     The Traf2- and Nck-interacting kinase as a putative effector of
            Rap2 to regulate actin cytoskeleton
  JOURNAL   J Biol Chem 279 (47), 49488-49496 (2004)
   PUBMED   15342639
REFERENCE   7  (bases 1 to 4416)
  AUTHORS   Machida,N., Umikawa,M., Takei,K., Sakima,N., Myagmar,B.E.,
            Taira,K., Uezato,H., Ogawa,Y. and Kariya,K.
  TITLE     Mitogen-activated protein kinase kinase kinase kinase 4 as a
            putative effector of Rap2 to activate the c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 279 (16), 15711-15714 (2004)
   PUBMED   14966141
REFERENCE   8  (bases 1 to 4416)
  AUTHORS   Menetrey,J. and Cherfils,J.
  TITLE     Structure of the small G protein Rap2 in a non-catalytic complex
            with GTP
  JOURNAL   Proteins 37 (3), 465-473 (1999)
   PUBMED   10591105
REFERENCE   9  (bases 1 to 4416)
  AUTHORS   Cherfils,J., Menetrey,J., Le Bras,G., Janoueix-Lerosey,I., de
            Gunzburg,J., Garel,J.R. and Auzat,I.
  TITLE     Crystal structures of the small G protein Rap2A in complex with its
            substrate GTP, with GDP and with GTPgammaS
  JOURNAL   EMBO J 16 (18), 5582-5591 (1997)
   PUBMED   9312017
REFERENCE   10 (bases 1 to 4416)
  AUTHORS   Lerosey,I., Chardin,P., de Gunzburg,J. and Tavitian,A.
  TITLE     The product of the rap2 gene, member of the ras superfamily.
            Biochemical characterization and site-directed mutagenesis
  JOURNAL   J Biol Chem 266 (7), 4315-4321 (1991)
   PUBMED   1900290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.927544.1,
                                           SRR26360181.2350052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               JAXUCZ010000015.1  104003477-104004062
            587-4416            JAXUCZ010000015.1  104027211-104031040
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..4416
                     /gene="Rap2a"
                     /note="RAP2A, member of RAS oncogene family"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
     exon            1..586
                     /gene="Rap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..824
                     /gene="Rap2a"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rap2A-like protein; ras-related protein Rap-2a; RAS
                     related protein 2a inverted question mark"
                     /codon_start=1
                     /product="ras-related protein Rap-2a isoform 1"
                     /protein_id="NP_001424944.1"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKRYEKVPVILVGNKVDLESEREVSSNEGRALAEEWGCPFMETSAKSKTMVDELFAEI
                     VRQMNYAAQPDKDDPCCSACNIQ"
     misc_feature    318..767
                     /gene="Rap2a"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; Region: Rap2; cd04176"
                     /db_xref="CDD:133376"
     misc_feature    318..767
                     /gene="Rap2a"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; Region: Rap2; cd04176"
                     /db_xref="CDD:133376"
     misc_feature    order(318..326,354..365,618..623,627..629,708..713)
                     /gene="Rap2a"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133376"
     misc_feature    order(318..326,354..365,618..623,627..629,708..713)
                     /gene="Rap2a"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133376"
     misc_feature    order(321..326,366..368,372..374,390..395,432..437,
                     441..443,447..452,714..716)
                     /gene="Rap2a"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(321..326,366..368,372..374,390..395,432..437,
                     441..443,447..452,714..716)
                     /gene="Rap2a"
                     /note="putative GEF interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(345..347,363..365,369..371,378..395)
                     /gene="Rap2a"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     misc_feature    order(345..347,363..365,369..371,378..395)
                     /gene="Rap2a"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     misc_feature    369..392
                     /gene="Rap2a"
                     /note="Switch I region; other site"
                     /db_xref="CDD:133376"
     misc_feature    369..392
                     /gene="Rap2a"
                     /note="Switch I region; other site"
                     /db_xref="CDD:133376"
     misc_feature    375..377
                     /gene="Rap2a"
                     /note="G2 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    375..377
                     /gene="Rap2a"
                     /note="G2 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    441..452
                     /gene="Rap2a"
                     /note="G3 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    441..452
                     /gene="Rap2a"
                     /note="G3 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(447..467,474..491,498..503)
                     /gene="Rap2a"
                     /note="Switch II region; other site"
                     /db_xref="CDD:133376"
     misc_feature    order(447..467,474..491,498..503)
                     /gene="Rap2a"
                     /note="Switch II region; other site"
                     /db_xref="CDD:133376"
     misc_feature    618..629
                     /gene="Rap2a"
                     /note="G4 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    618..629
                     /gene="Rap2a"
                     /note="G4 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    708..716
                     /gene="Rap2a"
                     /note="G5 box; other site"
                     /db_xref="CDD:133376"
     misc_feature    708..716
                     /gene="Rap2a"
                     /note="G5 box; other site"
                     /db_xref="CDD:133376"
     exon            587..4416
                     /gene="Rap2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcattgcgg ggccgcggtt cgggcggctc cggctcgggc tcgagctccg ttgctgccgg
       61 cgccctccag gctgcatcgt cctccggctt ggcccgctca cagggccgcg cgctgctccc
      121 tcagttgtag ctccgctgcc ggcgcccagg gcgctgccgc ggccgtgagc cggcgtgtcc
      181 gtaagggcgg cggggccgcg gggtcggggc gcggcgcgcg ggcgcaggtc tatgtcgcgg
      241 gcggcggcgg cggcggcggc cgcgcaggga cgatgcgcga gtacaaagtg gtggtgctgg
      301 gctcgggcgg ggtaggcaaa tccgccctga ccgtgcagtt cgtgaccggc accttcattg
      361 agaaatacga ccccaccatc gaggacttct accgcaagga gatcgaggtg gactcgtcgc
      421 cttcggtgtt ggagatcctg gacacggcgg gcaccgagca gttcgcgtcc atgcgggacc
      481 tgtacatcaa gaacggccag ggcttcatcc tggtctacag cctggtcaac cagcagagct
      541 tccaggatat caagcccatg cgggaccaga tcatccgcgt gaagcggtat gagaaggtgc
      601 cagtcatcct ggtcgggaac aaagtggacc tggagagtga gagagaagtg tcctccaacg
      661 aaggccgtgc cttggccgaa gagtggggct gcccctttat ggagacttct gctaagagta
      721 aaacaatggt ggatgaactc tttgctgaaa ttgtgaggca aatgaactat gcagctcagc
      781 ctgacaaaga tgacccatgt tgttctgcct gtaatataca atagcatccg aacatggccg
      841 tcccagacgg gactcatcta ggctcgtagg caacagtgac cttgtctact gcattgcagt
      901 ttgtaggatg ggtggtgtgt gagtccacgg tgcactgcgg ccggatggcc agctgacgcc
      961 tctgagtacc tgtgggtgcc cccgtgacta cagtctccac ctctgtcctc agtcctctgt
     1021 acgtctgcaa cctgaaggca ccacagcgaa gctacagggt gaccgcattt gatatgatga
     1081 tagtgttgcc gttgaggtga cagaagccac tgttgtgtaa actaaaaatc atcatgagag
     1141 agaaaccaga agaattccta tgatcactaa caaaatattt tgttgtctta aaaaaaataa
     1201 aggagaaata ttttcctaca agagtactga agtcaggaat ggatggagct tctagccagt
     1261 ttattccatc cagtgaaaca gcattgcagg gagactccac ctagctgaca cgtctctagt
     1321 tttcgaatcg atgcctaatc gtagatgtta ccctacttcg tgacatgaaa ctcactcaca
     1381 tatcagtcct cagcagagta aaagtcagag cacggctgtg tgagaaccca gtctggcttt
     1441 agaatttgtt gaatcacctg ctctgccaca gaaaatcgtc tctcacgagg gcttacgaga
     1501 atcgaacggc acacccgccc tctgttcctg gagcagggat ggtctttatt tactgaacaa
     1561 gaaagaagca cctgaggtgg cccagcctta ctaaggagcc ttgtagcaga ttcaccatcg
     1621 cagaagggaa atgaagccat gtcacatcca catgctcccc cttgcagaca ccccacggga
     1681 cagtgcaagc atccggcttt gtgtgtgtga gtgtatgtgt gtgagtgagt gtgtgtgtgt
     1741 gagtgtgagt gtgtgtgagt gtgtgagtgt gtgtgagtgt gtgtgagtgt gagtgtgagt
     1801 gagtgtgtgt gagtgtgtaa gtgagtgtgt gtcagtgtgt gagtgtgagt gtatgtgtgt
     1861 gagtgtatgt gtgagtgtat gtgtatgagt aggtgtgtgt gtgtgagtga gtgtatgtat
     1921 gtgtttgtgc gtgtgtgcat atgtgtgtga gtgtatgtat gtgtttgtgc atgcgtgtgt
     1981 gcatgcgtgt gttggtgaaa gcagcctgga agggccatgg ttgctgtgtg acccttggct
     2041 cgcctgcttt ggaaatccag tttactgtat cagagcttta ttgtaggcat ttaaaaaaaa
     2101 gaaacagatt gaataaccta tgaaataatt tgggcttaaa agtagaatat aaattatctg
     2161 agagggggaa gggacacaaa accccttctc ttccctttct tggagaatca cggaagcttc
     2221 ttgtgtacgt gttccgccct gacggctgaa atggcacaca tcgctagagc gcatcttcgg
     2281 ttttgaaagg gtgcttaagc tccagcgttt tttttggttc tcatagcagt gaagtgctta
     2341 tcatttgcat gagtaagggc acaggagaaa aacattttat tcaggagttt cacggtcgag
     2401 tatggaaggg ttctcacctc cgcgcagagg cctaagtgct ggtgaatgtc ttgagcctgc
     2461 cctctgaaga tcagtttggc cttcagaacc gcacagtgtc gctgagcctg gatgcactta
     2521 gggcccacgc cttctcggtt ccacagtctt gtgcaagtaa ccacttagtc tcgcgtgtac
     2581 cggagagaag agtgtgtttg tgtgtgcatg tgtgtttatc gttcctaaga atttggcaca
     2641 attctcgact gagaatctat actgcagaac ataatgttta agcaagcatt ttttaaaaaa
     2701 ttattagtct cttataagcc attgaaatct cgccacccca agtgtttagt agctggcttt
     2761 aaggttacaa gatgggggaa aaggtcaatg gaagggccag gaaaaaagta aataaataat
     2821 gtgggtaaaa ccaggttgtg ggtgttagag agtctttgag gattcttgtt caacgccatt
     2881 tctccacttc agaagtacca cattttatag gacaaaaagc cccaacagtt ttctcaaaac
     2941 aaagtttatt atgtaaaagt tgattttgac tcagacttat ggaaaaattg aactgaagaa
     3001 gtacgttttt atctgctgaa gtagaaatac tagtgtgttg acctctgagg cctctaactt
     3061 atccaactaa ttctaatttt cagaatccca taacgacaac aatttatgat actgcacatt
     3121 agaagcagct gtgcaggtcc cacagccaca ctgtgtatgg ccgtgcaagc atggaaaggg
     3181 ttacgtgtga gaagccaggc aaggtggaag tggggatatt tgcatttggg caggctcttc
     3241 ctgggaggca ttcctaaggc ccagcgtctg caccagccct tcacagtgcc caggcatcac
     3301 gcccccacgc tgaactgtgc caagccctct ccctgtccct ctggtacaag tctgacactt
     3361 gtgcatgata tttgccaaga tggggataaa aacccaagga caggaaagtg acacttgtca
     3421 gcacatgaac tggcagggca cagagaagag ccggcctgtc ggcatttctt taaagcctga
     3481 tccacctagc aaccagataa atgaaagttt gttctaacat gccttaaaat attatggttt
     3541 gacccaaaga cccactattt ctttagctat catttcgttt tctttgtttt tttttttttt
     3601 tttttgtttt gtttttaact ttcacacaga gccggatatt tttgttttat tttaggttta
     3661 tttcttctaa ggtgtaactt gtgggttctt taaagctgtg gcagtgatgg taaccaacgc
     3721 cttcccgctc ctcagctccc acaagacaag ccagcatctg ctgagaagcc ttctaggtgt
     3781 ttccgcacac cgtgaaaggt gctttgaaac tcccatcctc tgctttgtag aactagggcc
     3841 tgatgggcac tccagtcacc cactgtcact ctgtggtaaa actactgatg cttgcttgct
     3901 tcccgagttg cccgaggatg gctgccatgc gctgtccagt gtgagtgttg ctgctggtga
     3961 atttgaaggt gctttgtcct ccgctgctgt tggcttagtt gcttagtttc cccatcagtg
     4021 cccccactct ccccccctcc cgccccatta gcactggctc agctttaact gtctcctcag
     4081 ccaatcagat gttaaagacc atgggagtcc tcttgtttaa tttgtcctcg tgtatctatt
     4141 aaacctcgat cagggtttct agaatggctg cagtagattt tgaaaacaga cttaccgtta
     4201 tcgatttggg gtttcccaga gatccagttc acagttaatt gttgaactcg agtacaactg
     4261 accattcaaa agtgaacaac agcccattgt tttgtaacag tgtcgggtaa gccctgacat
     4321 ttcaattgaa acatgaattg tcattataac tcaatgcaaa ttcaacagtt gtatttggag
     4381 ttaaattatt ttaacaaata aatttattta atgaaa
//
LOCUS       NM_001438012            4345 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 6, mRNA.
ACCESSION   NM_001438012 XM_063288195
VERSION     NM_001438012.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4345)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 4345)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4345)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 4345)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_063288195.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1089669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1470              JAXUCZ010000005.1  29266793-29268262   c
            1471-1577           JAXUCZ010000005.1  29259227-29259333   c
            1578-1632           JAXUCZ010000005.1  29259048-29259102   c
            1633-1743           JAXUCZ010000005.1  29257470-29257580   c
            1744-1876           JAXUCZ010000005.1  29257227-29257359   c
            1877-1919           JAXUCZ010000005.1  29257087-29257129   c
            1920-2221           JAXUCZ010000005.1  29253546-29253847   c
            2222-2440           JAXUCZ010000005.1  29252420-29252638   c
            2441-2639           JAXUCZ010000005.1  29250290-29250488   c
            2640-2808           JAXUCZ010000005.1  29246768-29246936   c
            2809-4345           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..4345
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..4345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..1470
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1421..1423
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     exon            1471..1577
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     CDS             1505..2815
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 6 is encoded by transcript variant 6;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     6"
                     /protein_id="NP_001424941.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCS
                     KTELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFV
                     SEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRG
                     LPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKH
                     KDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVR
                     LRGLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQ
                     KYHKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAA
                     VIPTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSV"
     misc_feature    1634..1912
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1634..1912
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1916..2248
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1916..2248
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    2318..2560
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    2318..2560
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     exon            1578..1632
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1743
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1876
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1919
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2221
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2440
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2639
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2808
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..4345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacatgatt gtggggagac atagttctgt aattcatttg ggctaaatac caagaattgt
       61 aattactgga ttaatctagt acaactgcag tcactttgtc ttcatgcaat tttgtgtttt
      121 gaccgttctt ttggctttgg tagggaaagc agcaacttgg tagaacttgg ttgtgtgggg
      181 ggattttttg ggtttttttg tttttgtttt ttggtttttt tttgttgttg ttgtttgttt
      241 gtttttttga gaatgcaact cttttagcac ccagccctgg cctctgcctc tgcctctgcc
      301 tctgcccctg ccccagcccc agccccagcc ccagccccag ccccagccgt ggacccagtg
      361 ttggtgtttt atggtggaaa aggaagctaa aggtattggt gaagtgttgt agctgggtct
      421 tgagggtctg ccactctgta gattggcttt tgtgggagct gagcttccct ggttcccttt
      481 gcgttcccaa acgaaagctt catggacttt accgtgctcc gtatgggaga acgcatgctc
      541 catatgggag aacgcgtggc cgctctggtt ccttcggggt taggaactgt gctggtttct
      601 tccgcgcttt tcccaccgcg ttttttgtga ttgctctgaa actatttcta gtcttggttt
      661 gggcttccag agtaattcca gctgcaggtg tgctagtgtg tgcgttacac aatgctgcca
      721 ggaaccgcct tatctgccag gtgaactgtg caggtattaa atcaggcgac atggcgagag
      781 gaggatgggg cggagcttat cttcgttttg ttttgttttt aaggaaattc tgttcagttc
      841 cttggagaga ttaatagtag ctttttttct atttacgttt tgattacaga gccatttgta
      901 caaaggatat ttattcattt actaaaattg ctgcctttct taatccctga aattgaatta
      961 tttccttcta acttctgaag ctttttgctc gttttgcttt gctttttttg tttttgataa
     1021 atgttattta agacatatag gtctatagcc ctggctgtcc tggaacttga tacgtagagc
     1081 aaattggcct taaactcaca gggatccacc tgcctctgcc ttctcagtgc aggaattgaa
     1141 ggttcatcct gtcgctcatg aactgattta ttctcgttag ttaagatgtg cagcaatgtg
     1201 cgtttacttt tattgacaca cctttattaa gggcttacat tccatagagt ctaatgtaac
     1261 aaacctgtga aagaaagact gctcaggggc agggtaagac atagagacag agtatctaca
     1321 tagcctttgc agaggccctg ctttgagagc ccggccatca catccataca caagaaaata
     1381 ttgaaaatca gttacaccta ttgctttagt agcctcacag tagcctacta aaagggcatt
     1441 accccatcgt gtaaccagag aaactgagag tcccacaggc ctaaactttg agaagaatga
     1501 ctccatgtcc agatacggag cctcccaagt tgaagacatg gggaacataa ttttagcgat
     1561 gatctcagag ccctacaatc acagattttc agatccagag agagtaaact acaaatttga
     1621 aagtggcact tgcagcaaga cggagcttat cgatggcaac acggtggtga gggctcgagg
     1681 tttgccctgg cagtcttcag atcaagatat tgcaaggttc ttcaaaggac tcaatattgc
     1741 caagggtggt gcagctcttt gtctgaatgc tcaggggcgg aggaacgggg aagctctggt
     1801 tagatttgta agtgaggagc acagagatct ggccctgcag aggcacaaac atcatatggg
     1861 gacccgttac atcgaggttt acaaagcaac aggcgaagac tttcttaaaa ttgccggagg
     1921 gacatccaat gaggtggccc agtttctctc caaggaaaac caagtcatcg tgcgcatgcg
     1981 ggggctccct ttcacagcca cggcggaaga agtggtagcc ttctttggac agcactgccc
     2041 tatcactggg gggaaggaag gcatcctctt cgtcacctac ccagatggta ggcccacggg
     2101 agatgctttt gtgctctttg cttgtgagga gtatgctcag aacgccctga ggaagcacaa
     2161 ggacttgttg ggtaaaagat acatcgagct cttcagaagc acagcagctg aagttcagca
     2221 ggtgctgaat cggttctcct ccgctccttt gattccactt cccaccgctc ccatcatccc
     2281 tgtgctacct cagcagtttg tgccccccac aaatgtaaga gactgcgtac gtctgcgagg
     2341 tcttccctat gccgccacca tagaagacat tctggacttc ctgggggagt tttccacaga
     2401 cattcgtacg catggggttc acatggtatt gaaccaccag ggacgcccgt caggagatgc
     2461 ctttatccag atgaagtcta cagacagagc attcatggct gcgcagaagt atcataaaaa
     2521 aaccatgaag gacagatatg ttgaagtctt tcagtgttca gctgaggaga tgaactttgt
     2581 gttaatgggg ggcactttaa atcgaaatgg cttatcccca ccgccatgta agttaccatg
     2641 cctgtctcct ccctcctaca cattcccagc tcctgcagcc gtgattccta ccgaagctgc
     2701 catttatcag ccttccctgc tcttgaaccc acgggcactg cagccctcca ctgcttacta
     2761 cccagcaggc actcagctgt tcatgaacta cacagcctac tatcccagtg tttgaaagac
     2821 gcatggtgat cctgaaacta tcagacgaga acttctagca atttcagggg atgtttgtct
     2881 acactcaggc tgcggaagtt tcagccaacg gattggacag tgggcctggg ccttatcttt
     2941 tggtggagtg aaaaaacgtg gagccgtgga agccaaatct ttatagcaag cagtgtgcac
     3001 gaacctggct ccttgctgag tgcaaatagg aatttaaatg tgaatttgaa gtcaaagttc
     3061 tcacttccag ctaactggca acatttattt cctgagctga agtcttggag taaaatacat
     3121 tccagtagca tctaccatcc accattaatt gctatggaag cctcattgtg taccccactc
     3181 ttctgtctcc ctgttttctg taaaataaaa ccctcttgct aagtaattta agtgtacgtt
     3241 cttagaatac ttaagtccca aactaaagaa aaggaataaa ataaaattaa tattttccca
     3301 aatactagtt ttcttcaata ggccatcatg gtgccttatt gttaacaaca aatatttcta
     3361 aaatgtctca ggcaggctgg gcccatctcc gtggtaaaga gcttgcctgc ctagcacact
     3421 tgagccctgg gtttgcagac ctatcccctg tgtcctctcc acagtgcgcc cttccacacg
     3481 cgccttgtta aaggccttgc tgcgtgtttt tctctgcagg tatccgctgt aaataagaat
     3541 gaagtagggg ccaaaacctg aaaccaaaaa tgaagcagct ccttgtagtc ttagttccta
     3601 gtttgagctg tagctgactg cttggcttcc cgtgtattat tttatattgt gcttttgtca
     3661 ttgttaatgg tttggacttt aataagagaa atcccatagt ttttaatgtc acaaaaataa
     3721 gcctatttga acagtgtatt ccagaaagca atatactaac caaagtgaat gcttgtgtgt
     3781 attgataccc ttttcctctc taacgcctca actgtcaagg aactaaaacc tttaaaagca
     3841 taggcatgct ggcctgaggt aaacactggt acagttagag cggaggcagc agcccccggt
     3901 gttcagcaca gcttgtctga tgtgtttatg gccagagtgc agtattcggc actggctagt
     3961 accgctgcct gaccgaactc cactgggaag tggtttgctt aaacgcacat gtttctttgt
     4021 tactcctgac catgcttgga tgcagtgcct agattgtggc tgctattttt agttcgcatc
     4081 atgaccttga ctgcggagtc cagccttacc ctcttacttg acaacagtag cccttaaact
     4141 gcagtgggaa gaaagaagaa tttggtatga aaattggtga gctctggcac ttgagataaa
     4201 caagaagaaa gttccaactt gatgccttaa gccgctcctg cccgaagctc tgaaggacta
     4261 agttggcaga gatccttact ttgatactac tgcatttttt gtagaattgt tacattgata
     4321 ataaaacttg cctgcttaac ctcaa
//
LOCUS       NM_001127564            3870 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 3, mRNA.
ACCESSION   NM_001127564 XM_001064461 XM_575771
VERSION     NM_001127564.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3870)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 3870)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3870)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 3870)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced NM_001127564.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166735.1, SRR26643295.20643.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000005.1  29278875-29279380   c
            507-635             JAXUCZ010000005.1  29278248-29278376   c
            636-749             JAXUCZ010000005.1  29276909-29277022   c
            750-864             JAXUCZ010000005.1  29272117-29272231   c
            865-963             JAXUCZ010000005.1  29259227-29259325   c
            964-1018            JAXUCZ010000005.1  29259048-29259102   c
            1019-1129           JAXUCZ010000005.1  29257470-29257580   c
            1130-1262           JAXUCZ010000005.1  29257227-29257359   c
            1263-1305           JAXUCZ010000005.1  29257087-29257129   c
            1306-1607           JAXUCZ010000005.1  29253546-29253847   c
            1608-1826           JAXUCZ010000005.1  29252420-29252638   c
            1827-2013           JAXUCZ010000005.1  29250302-29250488   c
            2014-2182           JAXUCZ010000005.1  29246768-29246936   c
            2183-2333           JAXUCZ010000005.1  29237174-29237324   c
            2334-3870           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..3870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3870
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..506
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     CDS             375..2354
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 3 is encoded by transcript variant 3;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     3"
                     /protein_id="NP_001121036.2"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKT
                     ELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEA
                     AIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSSVP
                     PQPGTVVRMQGLAYNTGVKEILNFFQGYQCLKDAW"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    2001..2003
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); phosphorylation site"
     misc_feature    2106..2108
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); methylation site"
     misc_feature    2259..>2345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    2259..>2345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     exon            507..635
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            750..864
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1018
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1129
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1262
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1305
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1607
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1826
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2013
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2182
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2333
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..3870
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggga aaaggggcgg gcaggtagag ccacatccca aaacagaaaa gctttcagcc
       61 attgcgcgcg cctcccgggg gtgcagcccg gctcctgggg tttttttttc ttagacgcac
      121 gagcaattgg atacaaaaag ggcaggcctg ctgctccctc cttccacccc cccttcctgc
      181 ccagggtgtg gagcgccggc caggtgcggg cttgggtggc aggttaccgc cttttgccct
      241 ggcggcctcg aggagggggg tgggcgcttt ctttttctct tggaagaggg ttttagcaca
      301 ggttttctcg ttctcacttc caaccccacc tcgccgcctc ccgacccccc tcctcccctt
      361 ccccacctat cgtcatgacg gcgtctccgg attacttggt ggtgcttttt gggatcactg
      421 ctggggccac aggagccaag ctgggttcgg atgagaagga gctgatcctg ctgttatgga
      481 aagtcgtgga tttggccaac aagaaggtgg gacagttgca cgaagtacta gttagaccgg
      541 atcagttgga actgacagag gattgtaaag aagaaactaa aatagacgcc gaaaatctgt
      601 cttccgcccc gcagctggac caagccctcc gacagtttaa ccagtcagtg agcaatgaac
      661 tgaacattgg ggtagggact tccttctgtc tgtgtactga cgggcagctt cacgtcaggc
      721 agatcttgca tcccgaggct tccaagaaga atgtattact acctgaatgc ttctattcct
      781 ttttcgatct tcgaaaagaa ttcaagaagt gttgccccgg ctctcctgac ctcgacaagc
      841 tggatgttgc agccatggca gagagcctaa actttgagaa gaatgactcc atgtccagat
      901 acggagcctc ccaagttgaa gacatgggga acataatttt agcgatgatc tcagagccct
      961 acaatcacag attttcagat ccagagagag taaactacaa atttgaaagt ggcacttgca
     1021 gcaagacgga gcttatcgat ggcaacacgg tggtgagggc tcgaggtttg ccctggcagt
     1081 cttcagatca agatattgca aggttcttca aaggactcaa tattgccaag ggtggtgcag
     1141 ctctttgtct gaatgctcag gggcggagga acggggaagc tctggttaga tttgtaagtg
     1201 aggagcacag agatctggcc ctgcagaggc acaaacatca tatggggacc cgttacatcg
     1261 aggtttacaa agcaacaggc gaagactttc ttaaaattgc cggagggaca tccaatgagg
     1321 tggcccagtt tctctccaag gaaaaccaag tcatcgtgcg catgcggggg ctccctttca
     1381 cagccacggc ggaagaagtg gtagccttct ttggacagca ctgccctatc actgggggga
     1441 aggaaggcat cctcttcgtc acctacccag atggtaggcc cacgggagat gcttttgtgc
     1501 tctttgcttg tgaggagtat gctcagaacg ccctgaggaa gcacaaggac ttgttgggta
     1561 aaagatacat cgagctcttc agaagcacag cagctgaagt tcagcaggtg ctgaatcggt
     1621 tctcctccgc tcctttgatt ccacttccca ccgctcccat catccctgtg ctacctcagc
     1681 agtttgtgcc ccccacaaat gtaagagact gcgtacgtct gcgaggtctt ccctatgccg
     1741 ccaccataga agacattctg gacttcctgg gggagttttc cacagacatt cgtacgcatg
     1801 gggttcacat ggtattgaac caccagggac gcccgtcagg agatgccttt atccagatga
     1861 agtctacaga cagagcattc atggctgcgc agaagtatca taaaaaaacc atgaaggaca
     1921 gatatgttga agtctttcag tgttcagctg aggagatgaa ctttgtgtta atggggggca
     1981 ctttaaatcg aaatggctta tccccaccgc catgcctgtc tcctccctcc tacacattcc
     2041 cagctcctgc agccgtgatt cctaccgaag ctgccattta tcagccttcc ctgctcttga
     2101 acccacgggc actgcagccc tccactgctt actacccagc aggcactcag ctgttcatga
     2161 actacacagc ctactatccc agccccccag gttcgcctaa tagtcttggc tacttcccta
     2221 cagctgctaa tcttagcagt gtcccgcccc agcctggcac ggtggtcaga atgcagggcc
     2281 tggcctacaa tactggagtt aaggaaattc ttaacttctt ccaaggttac cagtgtttga
     2341 aagacgcatg gtgatcctga aactatcaga cgagaacttc tagcaatttc aggggatgtt
     2401 tgtctacact caggctgcgg aagtttcagc caacggattg gacagtgggc ctgggcctta
     2461 tcttttggtg gagtgaaaaa acgtggagcc gtggaagcca aatctttata gcaagcagtg
     2521 tgcacgaacc tggctccttg ctgagtgcaa ataggaattt aaatgtgaat ttgaagtcaa
     2581 agttctcact tccagctaac tggcaacatt tatttcctga gctgaagtct tggagtaaaa
     2641 tacattccag tagcatctac catccaccat taattgctat ggaagcctca ttgtgtaccc
     2701 cactcttctg tctccctgtt ttctgtaaaa taaaaccctc ttgctaagta atttaagtgt
     2761 acgttcttag aatacttaag tcccaaacta aagaaaagga ataaaataaa attaatattt
     2821 tcccaaatac tagttttctt caataggcca tcatggtgcc ttattgttaa caacaaatat
     2881 ttctaaaatg tctcaggcag gctgggccca tctccgtggt aaagagcttg cctgcctagc
     2941 acacttgagc cctgggtttg cagacctatc ccctgtgtcc tctccacagt gcgcccttcc
     3001 acacgcgcct tgttaaaggc cttgctgcgt gtttttctct gcaggtatcc gctgtaaata
     3061 agaatgaagt aggggccaaa acctgaaacc aaaaatgaag cagctccttg tagtcttagt
     3121 tcctagtttg agctgtagct gactgcttgg cttcccgtgt attattttat attgtgcttt
     3181 tgtcattgtt aatggtttgg actttaataa gagaaatccc atagttttta atgtcacaaa
     3241 aataagccta tttgaacagt gtattccaga aagcaatata ctaaccaaag tgaatgcttg
     3301 tgtgtattga tacccttttc ctctctaacg cctcaactgt caaggaacta aaacctttaa
     3361 aagcataggc atgctggcct gaggtaaaca ctggtacagt tagagcggag gcagcagccc
     3421 ccggtgttca gcacagcttg tctgatgtgt ttatggccag agtgcagtat tcggcactgg
     3481 ctagtaccgc tgcctgaccg aactccactg ggaagtggtt tgcttaaacg cacatgtttc
     3541 tttgttactc ctgaccatgc ttggatgcag tgcctagatt gtggctgcta tttttagttc
     3601 gcatcatgac cttgactgcg gagtccagcc ttaccctctt acttgacaac agtagccctt
     3661 aaactgcagt gggaagaaag aagaatttgg tatgaaaatt ggtgagctct ggcacttgag
     3721 ataaacaaga agaaagttcc aacttgatgc cttaagccgc tcctgcccga agctctgaag
     3781 gactaagttg gcagagatcc ttactttgat actactgcat tttttgtaga attgttacat
     3841 tgataataaa acttgcctgc ttaacctcaa
//
LOCUS       NM_001438010            3728 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 4, mRNA.
ACCESSION   NM_001438010 XM_063288192
VERSION     NM_001438010.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3728)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 3728)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3728)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 3728)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_063288192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.515046.1,
                                           SRR26643291.14359.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000005.1  29278875-29279380   c
            507-635             JAXUCZ010000005.1  29278248-29278376   c
            636-749             JAXUCZ010000005.1  29276909-29277022   c
            750-864             JAXUCZ010000005.1  29272117-29272231   c
            865-963             JAXUCZ010000005.1  29259227-29259325   c
            964-1018            JAXUCZ010000005.1  29259048-29259102   c
            1019-1126           JAXUCZ010000005.1  29257470-29257577   c
            1127-1259           JAXUCZ010000005.1  29257227-29257359   c
            1260-1302           JAXUCZ010000005.1  29257087-29257129   c
            1303-1604           JAXUCZ010000005.1  29253546-29253847   c
            1605-1823           JAXUCZ010000005.1  29252420-29252638   c
            1824-2022           JAXUCZ010000005.1  29250290-29250488   c
            2023-2191           JAXUCZ010000005.1  29246768-29246936   c
            2192-3728           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..3728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3728
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..506
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     CDS             375..2198
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 4 is encoded by transcript variant 4;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     4"
                     /protein_id="NP_001424939.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCKTE
                     LIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSEE
                     HRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLPF
                     TATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKDL
                     LGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLRG
                     LPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKYH
                     KKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIP
                     TEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSV"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    1020..1295
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1295
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1299..1631
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1299..1631
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1701..1943
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1701..1943
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1998..2000
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); phosphorylation site"
     misc_feature    2115..2117
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); methylation site"
     exon            507..635
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            750..864
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1018
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1126
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1259
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1302
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1604
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1823
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2022
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2191
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..3728
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggga aaaggggcgg gcaggtagag ccacatccca aaacagaaaa gctttcagcc
       61 attgcgcgcg cctcccgggg gtgcagcccg gctcctgggg tttttttttc ttagacgcac
      121 gagcaattgg atacaaaaag ggcaggcctg ctgctccctc cttccacccc cccttcctgc
      181 ccagggtgtg gagcgccggc caggtgcggg cttgggtggc aggttaccgc cttttgccct
      241 ggcggcctcg aggagggggg tgggcgcttt ctttttctct tggaagaggg ttttagcaca
      301 ggttttctcg ttctcacttc caaccccacc tcgccgcctc ccgacccccc tcctcccctt
      361 ccccacctat cgtcatgacg gcgtctccgg attacttggt ggtgcttttt gggatcactg
      421 ctggggccac aggagccaag ctgggttcgg atgagaagga gctgatcctg ctgttatgga
      481 aagtcgtgga tttggccaac aagaaggtgg gacagttgca cgaagtacta gttagaccgg
      541 atcagttgga actgacagag gattgtaaag aagaaactaa aatagacgcc gaaaatctgt
      601 cttccgcccc gcagctggac caagccctcc gacagtttaa ccagtcagtg agcaatgaac
      661 tgaacattgg ggtagggact tccttctgtc tgtgtactga cgggcagctt cacgtcaggc
      721 agatcttgca tcccgaggct tccaagaaga atgtattact acctgaatgc ttctattcct
      781 ttttcgatct tcgaaaagaa ttcaagaagt gttgccccgg ctctcctgac ctcgacaagc
      841 tggatgttgc agccatggca gagagcctaa actttgagaa gaatgactcc atgtccagat
      901 acggagcctc ccaagttgaa gacatgggga acataatttt agcgatgatc tcagagccct
      961 acaatcacag attttcagat ccagagagag taaactacaa atttgaaagt ggcacttgca
     1021 agacggagct tatcgatggc aacacggtgg tgagggctcg aggtttgccc tggcagtctt
     1081 cagatcaaga tattgcaagg ttcttcaaag gactcaatat tgccaagggt ggtgcagctc
     1141 tttgtctgaa tgctcagggg cggaggaacg gggaagctct ggttagattt gtaagtgagg
     1201 agcacagaga tctggccctg cagaggcaca aacatcatat ggggacccgt tacatcgagg
     1261 tttacaaagc aacaggcgaa gactttctta aaattgccgg agggacatcc aatgaggtgg
     1321 cccagtttct ctccaaggaa aaccaagtca tcgtgcgcat gcgggggctc cctttcacag
     1381 ccacggcgga agaagtggta gccttctttg gacagcactg ccctatcact ggggggaagg
     1441 aaggcatcct cttcgtcacc tacccagatg gtaggcccac gggagatgct tttgtgctct
     1501 ttgcttgtga ggagtatgct cagaacgccc tgaggaagca caaggacttg ttgggtaaaa
     1561 gatacatcga gctcttcaga agcacagcag ctgaagttca gcaggtgctg aatcggttct
     1621 cctccgctcc tttgattcca cttcccaccg ctcccatcat ccctgtgcta cctcagcagt
     1681 ttgtgccccc cacaaatgta agagactgcg tacgtctgcg aggtcttccc tatgccgcca
     1741 ccatagaaga cattctggac ttcctggggg agttttccac agacattcgt acgcatgggg
     1801 ttcacatggt attgaaccac cagggacgcc cgtcaggaga tgcctttatc cagatgaagt
     1861 ctacagacag agcattcatg gctgcgcaga agtatcataa aaaaaccatg aaggacagat
     1921 atgttgaagt ctttcagtgt tcagctgagg agatgaactt tgtgttaatg gggggcactt
     1981 taaatcgaaa tggcttatcc ccaccgccat gtaagttacc atgcctgtct cctccctcct
     2041 acacattccc agctcctgca gccgtgattc ctaccgaagc tgccatttat cagccttccc
     2101 tgctcttgaa cccacgggca ctgcagccct ccactgctta ctacccagca ggcactcagc
     2161 tgttcatgaa ctacacagcc tactatccca gtgtttgaaa gacgcatggt gatcctgaaa
     2221 ctatcagacg agaacttcta gcaatttcag gggatgtttg tctacactca ggctgcggaa
     2281 gtttcagcca acggattgga cagtgggcct gggccttatc ttttggtgga gtgaaaaaac
     2341 gtggagccgt ggaagccaaa tctttatagc aagcagtgtg cacgaacctg gctccttgct
     2401 gagtgcaaat aggaatttaa atgtgaattt gaagtcaaag ttctcacttc cagctaactg
     2461 gcaacattta tttcctgagc tgaagtcttg gagtaaaata cattccagta gcatctacca
     2521 tccaccatta attgctatgg aagcctcatt gtgtacccca ctcttctgtc tccctgtttt
     2581 ctgtaaaata aaaccctctt gctaagtaat ttaagtgtac gttcttagaa tacttaagtc
     2641 ccaaactaaa gaaaaggaat aaaataaaat taatattttc ccaaatacta gttttcttca
     2701 ataggccatc atggtgcctt attgttaaca acaaatattt ctaaaatgtc tcaggcaggc
     2761 tgggcccatc tccgtggtaa agagcttgcc tgcctagcac acttgagccc tgggtttgca
     2821 gacctatccc ctgtgtcctc tccacagtgc gcccttccac acgcgccttg ttaaaggcct
     2881 tgctgcgtgt ttttctctgc aggtatccgc tgtaaataag aatgaagtag gggccaaaac
     2941 ctgaaaccaa aaatgaagca gctccttgta gtcttagttc ctagtttgag ctgtagctga
     3001 ctgcttggct tcccgtgtat tattttatat tgtgcttttg tcattgttaa tggtttggac
     3061 tttaataaga gaaatcccat agtttttaat gtcacaaaaa taagcctatt tgaacagtgt
     3121 attccagaaa gcaatatact aaccaaagtg aatgcttgtg tgtattgata cccttttcct
     3181 ctctaacgcc tcaactgtca aggaactaaa acctttaaaa gcataggcat gctggcctga
     3241 ggtaaacact ggtacagtta gagcggaggc agcagccccc ggtgttcagc acagcttgtc
     3301 tgatgtgttt atggccagag tgcagtattc ggcactggct agtaccgctg cctgaccgaa
     3361 ctccactggg aagtggtttg cttaaacgca catgtttctt tgttactcct gaccatgctt
     3421 ggatgcagtg cctagattgt ggctgctatt tttagttcgc atcatgacct tgactgcgga
     3481 gtccagcctt accctcttac ttgacaacag tagcccttaa actgcagtgg gaagaaagaa
     3541 gaatttggta tgaaaattgg tgagctctgg cacttgagat aaacaagaag aaagttccaa
     3601 cttgatgcct taagccgctc ctgcccgaag ctctgaagga ctaagttggc agagatcctt
     3661 actttgatac tactgcattt tttgtagaat tgttacattg ataataaaac ttgcctgctt
     3721 aacctcaa
//
LOCUS       NM_001438011            3719 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 5, mRNA.
ACCESSION   NM_001438011 XM_063288193
VERSION     NM_001438011.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_063288193.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1652073.1,
                                           SRR26643297.18274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000005.1  29278875-29279380   c
            507-635             JAXUCZ010000005.1  29278248-29278376   c
            636-749             JAXUCZ010000005.1  29276909-29277022   c
            750-864             JAXUCZ010000005.1  29272117-29272231   c
            865-963             JAXUCZ010000005.1  29259227-29259325   c
            964-1018            JAXUCZ010000005.1  29259048-29259102   c
            1019-1129           JAXUCZ010000005.1  29257470-29257580   c
            1130-1262           JAXUCZ010000005.1  29257227-29257359   c
            1263-1305           JAXUCZ010000005.1  29257087-29257129   c
            1306-1607           JAXUCZ010000005.1  29253546-29253847   c
            1608-1826           JAXUCZ010000005.1  29252420-29252638   c
            1827-2013           JAXUCZ010000005.1  29250302-29250488   c
            2014-2182           JAXUCZ010000005.1  29246768-29246936   c
            2183-3719           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3719
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..506
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     CDS             375..2189
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 5 is encoded by transcript variant 5;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     5"
                     /protein_id="NP_001424940.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKT
                     ELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEA
                     AIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSV"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    2001..2003
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); phosphorylation site"
     misc_feature    2106..2108
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); methylation site"
     exon            507..635
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            750..864
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1018
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1129
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1262
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1305
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1607
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1826
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2013
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2182
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..3719
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggga aaaggggcgg gcaggtagag ccacatccca aaacagaaaa gctttcagcc
       61 attgcgcgcg cctcccgggg gtgcagcccg gctcctgggg tttttttttc ttagacgcac
      121 gagcaattgg atacaaaaag ggcaggcctg ctgctccctc cttccacccc cccttcctgc
      181 ccagggtgtg gagcgccggc caggtgcggg cttgggtggc aggttaccgc cttttgccct
      241 ggcggcctcg aggagggggg tgggcgcttt ctttttctct tggaagaggg ttttagcaca
      301 ggttttctcg ttctcacttc caaccccacc tcgccgcctc ccgacccccc tcctcccctt
      361 ccccacctat cgtcatgacg gcgtctccgg attacttggt ggtgcttttt gggatcactg
      421 ctggggccac aggagccaag ctgggttcgg atgagaagga gctgatcctg ctgttatgga
      481 aagtcgtgga tttggccaac aagaaggtgg gacagttgca cgaagtacta gttagaccgg
      541 atcagttgga actgacagag gattgtaaag aagaaactaa aatagacgcc gaaaatctgt
      601 cttccgcccc gcagctggac caagccctcc gacagtttaa ccagtcagtg agcaatgaac
      661 tgaacattgg ggtagggact tccttctgtc tgtgtactga cgggcagctt cacgtcaggc
      721 agatcttgca tcccgaggct tccaagaaga atgtattact acctgaatgc ttctattcct
      781 ttttcgatct tcgaaaagaa ttcaagaagt gttgccccgg ctctcctgac ctcgacaagc
      841 tggatgttgc agccatggca gagagcctaa actttgagaa gaatgactcc atgtccagat
      901 acggagcctc ccaagttgaa gacatgggga acataatttt agcgatgatc tcagagccct
      961 acaatcacag attttcagat ccagagagag taaactacaa atttgaaagt ggcacttgca
     1021 gcaagacgga gcttatcgat ggcaacacgg tggtgagggc tcgaggtttg ccctggcagt
     1081 cttcagatca agatattgca aggttcttca aaggactcaa tattgccaag ggtggtgcag
     1141 ctctttgtct gaatgctcag gggcggagga acggggaagc tctggttaga tttgtaagtg
     1201 aggagcacag agatctggcc ctgcagaggc acaaacatca tatggggacc cgttacatcg
     1261 aggtttacaa agcaacaggc gaagactttc ttaaaattgc cggagggaca tccaatgagg
     1321 tggcccagtt tctctccaag gaaaaccaag tcatcgtgcg catgcggggg ctccctttca
     1381 cagccacggc ggaagaagtg gtagccttct ttggacagca ctgccctatc actgggggga
     1441 aggaaggcat cctcttcgtc acctacccag atggtaggcc cacgggagat gcttttgtgc
     1501 tctttgcttg tgaggagtat gctcagaacg ccctgaggaa gcacaaggac ttgttgggta
     1561 aaagatacat cgagctcttc agaagcacag cagctgaagt tcagcaggtg ctgaatcggt
     1621 tctcctccgc tcctttgatt ccacttccca ccgctcccat catccctgtg ctacctcagc
     1681 agtttgtgcc ccccacaaat gtaagagact gcgtacgtct gcgaggtctt ccctatgccg
     1741 ccaccataga agacattctg gacttcctgg gggagttttc cacagacatt cgtacgcatg
     1801 gggttcacat ggtattgaac caccagggac gcccgtcagg agatgccttt atccagatga
     1861 agtctacaga cagagcattc atggctgcgc agaagtatca taaaaaaacc atgaaggaca
     1921 gatatgttga agtctttcag tgttcagctg aggagatgaa ctttgtgtta atggggggca
     1981 ctttaaatcg aaatggctta tccccaccgc catgcctgtc tcctccctcc tacacattcc
     2041 cagctcctgc agccgtgatt cctaccgaag ctgccattta tcagccttcc ctgctcttga
     2101 acccacgggc actgcagccc tccactgctt actacccagc aggcactcag ctgttcatga
     2161 actacacagc ctactatccc agtgtttgaa agacgcatgg tgatcctgaa actatcagac
     2221 gagaacttct agcaatttca ggggatgttt gtctacactc aggctgcgga agtttcagcc
     2281 aacggattgg acagtgggcc tgggccttat cttttggtgg agtgaaaaaa cgtggagccg
     2341 tggaagccaa atctttatag caagcagtgt gcacgaacct ggctccttgc tgagtgcaaa
     2401 taggaattta aatgtgaatt tgaagtcaaa gttctcactt ccagctaact ggcaacattt
     2461 atttcctgag ctgaagtctt ggagtaaaat acattccagt agcatctacc atccaccatt
     2521 aattgctatg gaagcctcat tgtgtacccc actcttctgt ctccctgttt tctgtaaaat
     2581 aaaaccctct tgctaagtaa tttaagtgta cgttcttaga atacttaagt cccaaactaa
     2641 agaaaaggaa taaaataaaa ttaatatttt cccaaatact agttttcttc aataggccat
     2701 catggtgcct tattgttaac aacaaatatt tctaaaatgt ctcaggcagg ctgggcccat
     2761 ctccgtggta aagagcttgc ctgcctagca cacttgagcc ctgggtttgc agacctatcc
     2821 cctgtgtcct ctccacagtg cgcccttcca cacgcgcctt gttaaaggcc ttgctgcgtg
     2881 tttttctctg caggtatccg ctgtaaataa gaatgaagta ggggccaaaa cctgaaacca
     2941 aaaatgaagc agctccttgt agtcttagtt cctagtttga gctgtagctg actgcttggc
     3001 ttcccgtgta ttattttata ttgtgctttt gtcattgtta atggtttgga ctttaataag
     3061 agaaatccca tagtttttaa tgtcacaaaa ataagcctat ttgaacagtg tattccagaa
     3121 agcaatatac taaccaaagt gaatgcttgt gtgtattgat acccttttcc tctctaacgc
     3181 ctcaactgtc aaggaactaa aacctttaaa agcataggca tgctggcctg aggtaaacac
     3241 tggtacagtt agagcggagg cagcagcccc cggtgttcag cacagcttgt ctgatgtgtt
     3301 tatggccaga gtgcagtatt cggcactggc tagtaccgct gcctgaccga actccactgg
     3361 gaagtggttt gcttaaacgc acatgtttct ttgttactcc tgaccatgct tggatgcagt
     3421 gcctagattg tggctgctat ttttagttcg catcatgacc ttgactgcgg agtccagcct
     3481 taccctctta cttgacaaca gtagccctta aactgcagtg ggaagaaaga agaatttggt
     3541 atgaaaattg gtgagctctg gcacttgaga taaacaagaa gaaagttcca acttgatgcc
     3601 ttaagccgct cctgcccgaa gctctgaagg actaagttgg cagagatcct tactttgata
     3661 ctactgcatt ttttgtagaa ttgttacatt gataataaaa cttgcctgct taacctcaa
//
LOCUS       NM_001438013            7397 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 7, mRNA.
ACCESSION   NM_001438013 XM_063288196
VERSION     NM_001438013.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7397)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 7397)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7397)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 7397)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_063288196.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1157303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4534              JAXUCZ010000005.1  29261575-29266108   c
            4535-4641           JAXUCZ010000005.1  29259227-29259333   c
            4642-4696           JAXUCZ010000005.1  29259048-29259102   c
            4697-4807           JAXUCZ010000005.1  29257470-29257580   c
            4808-4940           JAXUCZ010000005.1  29257227-29257359   c
            4941-4983           JAXUCZ010000005.1  29257087-29257129   c
            4984-5285           JAXUCZ010000005.1  29253546-29253847   c
            5286-5504           JAXUCZ010000005.1  29252420-29252638   c
            5505-5691           JAXUCZ010000005.1  29250302-29250488   c
            5692-5860           JAXUCZ010000005.1  29246768-29246936   c
            5861-7397           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..7397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..7397
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..4534
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4500..4502
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     exon            4535..4641
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     CDS             4569..5867
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 7 is encoded by transcript variant 7;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     7"
                     /protein_id="NP_001424942.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCS
                     KTELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFV
                     SEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRG
                     LPFTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKH
                     KDLLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVR
                     LRGLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQ
                     KYHKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPT
                     EAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSV"
     misc_feature    4698..4976
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    4698..4976
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    4980..5312
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    4980..5312
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    5382..5624
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    5382..5624
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     exon            4642..4696
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4807
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4940
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..4983
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            4984..5285
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5504
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            5505..5691
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            5692..5860
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            5861..7397
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagctgatct ctgagttcaa ggccagccag ggctacatag agaaactccg tctctaagaa
       61 tgaaaacaaa atatgaggtc tagggtgtaa tgtattagag tcgggctgtt ggcagtcgtc
      121 agcctcggtt tccttgtatt aaagcagaaa agacttgaaa taatgaccat ggtgcatgtg
      181 accacattat ccagtgctgg ccactctgtt tcctcctagg ttattgggac tatccaaaga
      241 gataacacag tggcaaacag ctttaagatg gacttcctta ttgatttaaa atgtgtttga
      301 actattccac acttaaagtt ttgaacctcg tgtgacgctg gctagagaac tttgaaggct
      361 tcaggtccat gttagtgcct gaacaatggc cttgctaacg tgtccttttc tttaagacac
      421 tgtgattgtg gctcattttt gcatgaggtt ttttacagtt agttgaacag ggccattgta
      481 attgcccaag ccactaccca attcaaaaga tggccgaaag cataccgact gtttcccccg
      541 tagccacttc ttcatatgaa aaggatttaa aatatcctca catgcacggt taaggcacgc
      601 tctgttagac agccttgtta cctggagggg gaagaaatta tctttggcat cccatcatcg
      661 ccaggcactg tttgaagcaa gcgaccaagc acattggctt gtggtcctgt ggtaagttaa
      721 gcaactggaa gtgactgctt gtttctggct agcacgcaaa taaattttgt gtggcttatt
      781 ttaattctac aagtgtcatt ttgttttcga tgaagctcag ttggtaggtg cttgtctagg
      841 gctcaggaag ccctgggttt aataaccgat gtttatcgct acgactgcgt aaaccagatg
      901 ttcacgtggt aaggcacatt ctaattccag cacaagagga gcgagggcag gaaagtcagg
      961 agttgagggt catcctcaac tatgtagtca catggaacta catgtagtcg caagcatgca
     1021 cacacaggag attaagagca tacgtatgta catgtgagag agaaacgaca tagagttaag
     1081 atgggggtgg gaggcttggg ggcacagaag gagttaagag gggtgggtgg gtgagtgtga
     1141 aagtaagttt gaccgaaaca aaaatttatt caaattaaag actttagttt tgtttttatg
     1201 gagtttttat ctaattttct tgctttatat aaatatcctt ttgcctgtat aggtgatttc
     1261 tctgagggtc tgaggccagc ctggactaga tagtttgttc tggcataacc tgagatagac
     1321 accctcaccc caaaattttt gtatttatat tcagtttgtt gcagtgctgg ggggctgatc
     1381 ctggggtctt gtgtaggtca ggaaaacagc gtgccactgt tccgtatctc ccaactctta
     1441 aatatgcccg tgtccttgga ttttcttttt ttcttttttt tctttttttt gagatgccat
     1501 ttcactgtga cgccaccgtg gcctcatggg tctgcacttt cggccttcca agtagccaag
     1561 gttcagatgt gagctgccac ttgattgttg gctcgtgcct acctacagct tactgcttgc
     1621 agggtgtatg tgactcgggg tagggctccg ggagggggtt aaattccttc acttggtccc
     1681 cttcattatg ctcatgactc caggacatag ggtttgttac atagagattt tttttttctt
     1741 ggaaagagta aaaattaaac taatactttg aatatttttc ctttagcata tttctggtat
     1801 aagagtttgc tgccgtggct tgcttgattg attgttgatt gattgattga ttgattgaca
     1861 gggtttccct ctattgccct gactgtcctg gaactcaacc ctcagactaa gctgcctctg
     1921 cctcctgagt gctgggatta aaggtaggtg ccaccactgc ctggcatggg gttactttag
     1981 ttgtgtatgt gtgaaagaca gggtcttgtg ttccagctgg cctccaacat gctgtgtgat
     2041 ggagaaagac ctcttgattc tcttccttct gcatccctaa tgctccaact tgttccgtag
     2101 catttatgca gggcgtaaat ccatgacctc atggagccta cgcaggtgct ccacccactg
     2161 agctacacct tcagcccaaa ctttgttttt cttttcattt taaaatgtgt acgggttttt
     2221 cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt tgcttgcgtg tgtttgcacg
     2281 agtgtctgtg tctgtgtacc atatttgtgt ggttcccaaa aaaaagggtc tgatttctca
     2341 gactggagtt ccagtcagct tgtgagtctc catgttggaa tagggaacca aatcctgccc
     2401 ccttgagaga gcagccagta ctcttaactt ctgagtcatc tctccagccc tatatgatat
     2461 tttgggaaaa gcctatataa cgcttgttat tttcttcttc atccttctcc tacacttgtg
     2521 ggaatattgg ttcttggggt accactgctg tgtgctaccc gttggctact cctttttcag
     2581 caccatggcc atattaatgt ttggcaacat agtatgtgtg ttacactaaa tacaacaagg
     2641 cagtaacaag accgtcttct gatgagtctt gggcagggct ttgatggaga atttctgctg
     2701 agatgttatt ttgagacttc ttccctaact aatatatttt ctgtttcatg tgtggttgtc
     2761 ttagatacaa actaaagcca caacttcaga agaggggctg tcgtttacat gcggaaagta
     2821 aatacattgg aagggtgtcc attttctgac agtcagggaa gaaattgtca gtgtagtccg
     2881 taagctggga gagatgtgct ttatgggggc ctatttcatc aaagggtggt gataaaggga
     2941 agactcctgt agttaaaaca cagcctcatc tgcctgtccc accctcttta tggacgaata
     3001 ccgtcttcag tatagcctga aatgtaggtt ttcgttccca ccacgctagg ctgtgttctt
     3061 tattccctcc tggcacttct ggtttgtaaa actggctgag cctgtctgtg ctgttgtagc
     3121 tgcccgaggg cacagttgag taagttacag gaccagcctt gcagtaaacc aggaggcgta
     3181 ggctccgtgc accttctctc agcaccagat gtggcagcaa ctaatccaaa atgtcatggg
     3241 ccttgatgca agaaagtgtt ggtgctaaag cattaggaaa ccccctaggg ctggggacag
     3301 ctcaccagtg gtgtagtcct aacacgcaca agaaacagga aagaaacccc ttccctttgt
     3361 tgtttgcgtt caactctggt gaggaaacag accgagcgta tgtaaggagg tacgcgcaca
     3421 catgtgtaag gatggggttt gggcacggga cttgtaaaag ttgctacagc ttcgagctgc
     3481 tggtctctat ggtggcacaa tgggaaatgc ggtggtatgt attatataga accgtctaag
     3541 ccaaaggcct gggacatagt cttaattaaa agtgagaatt tagtaaaacg atcctttagc
     3601 tgccaatctg tttcattata aaaaaagaga ccgtactcct acgtttgatc tttctcctat
     3661 aaatttgata tctttttctc aaaatactgc tcaaagtaaa aacagattga gcaaagcctt
     3721 tctaacttag cagggacttc tgtgttcagt caaagtgtgg ctgttacaat tccagtccct
     3781 tcacctacaa tggaaaagct gagttgggaa acatctctga attctagcta cttcttattg
     3841 ttggtgttga tgtctcctcc ctgatgattc gatatcttgt atagtgaagg aaacacacac
     3901 atacactcag aggggggtgg cgggaggaga aagagaacca aacctacttg gatcccagta
     3961 ctcgggaggc agaggaatcg agggttcaag gctagggtgg tctataagcg agttccagac
     4021 caggcagaac tacataagtg agacttgtct caaacaaaga aacaaatgtc aaatctgtgc
     4081 atgaaaagaa aactgtagct cagtctctcg tcaacaggcc tgtgtgtaca tgatgaaagt
     4141 gggaggtcct ggggctggtc cttcatggcc tctcagagaa gagagccccc atcctggagg
     4201 cagcctgcag ctctgcacag cggtatcccc agcagacttg ggaaaggagc tgcacaccct
     4261 ttgacttgag cgtcctggat tttctacgtg acgcccacag tgaattgtct gttgaaagtg
     4321 gctccctgta ggccgtaaga actcttgagg gcacaccatc tttgtctttc ctggagcatc
     4381 actgcaaagt agttctacag aactgaattt tgaggatgag tgaactagat caaaggacgg
     4441 cgcggtccat gctcagggac tgcgtgtgat actatcgaga agaccagttt cctaggatgt
     4501 agctgacaga attgccgact gtgccccaga gcagtcccac aggcctaaac tttgagaaga
     4561 atgactccat gtccagatac ggagcctccc aagttgaaga catggggaac ataattttag
     4621 cgatgatctc agagccctac aatcacagat tttcagatcc agagagagta aactacaaat
     4681 ttgaaagtgg cacttgcagc aagacggagc ttatcgatgg caacacggtg gtgagggctc
     4741 gaggtttgcc ctggcagtct tcagatcaag atattgcaag gttcttcaaa ggactcaata
     4801 ttgccaaggg tggtgcagct ctttgtctga atgctcaggg gcggaggaac ggggaagctc
     4861 tggttagatt tgtaagtgag gagcacagag atctggccct gcagaggcac aaacatcata
     4921 tggggacccg ttacatcgag gtttacaaag caacaggcga agactttctt aaaattgccg
     4981 gagggacatc caatgaggtg gcccagtttc tctccaagga aaaccaagtc atcgtgcgca
     5041 tgcgggggct ccctttcaca gccacggcgg aagaagtggt agccttcttt ggacagcact
     5101 gccctatcac tggggggaag gaaggcatcc tcttcgtcac ctacccagat ggtaggccca
     5161 cgggagatgc ttttgtgctc tttgcttgtg aggagtatgc tcagaacgcc ctgaggaagc
     5221 acaaggactt gttgggtaaa agatacatcg agctcttcag aagcacagca gctgaagttc
     5281 agcaggtgct gaatcggttc tcctccgctc ctttgattcc acttcccacc gctcccatca
     5341 tccctgtgct acctcagcag tttgtgcccc ccacaaatgt aagagactgc gtacgtctgc
     5401 gaggtcttcc ctatgccgcc accatagaag acattctgga cttcctgggg gagttttcca
     5461 cagacattcg tacgcatggg gttcacatgg tattgaacca ccagggacgc ccgtcaggag
     5521 atgcctttat ccagatgaag tctacagaca gagcattcat ggctgcgcag aagtatcata
     5581 aaaaaaccat gaaggacaga tatgttgaag tctttcagtg ttcagctgag gagatgaact
     5641 ttgtgttaat ggggggcact ttaaatcgaa atggcttatc cccaccgcca tgcctgtctc
     5701 ctccctccta cacattccca gctcctgcag ccgtgattcc taccgaagct gccatttatc
     5761 agccttccct gctcttgaac ccacgggcac tgcagccctc cactgcttac tacccagcag
     5821 gcactcagct gttcatgaac tacacagcct actatcccag tgtttgaaag acgcatggtg
     5881 atcctgaaac tatcagacga gaacttctag caatttcagg ggatgtttgt ctacactcag
     5941 gctgcggaag tttcagccaa cggattggac agtgggcctg ggccttatct tttggtggag
     6001 tgaaaaaacg tggagccgtg gaagccaaat ctttatagca agcagtgtgc acgaacctgg
     6061 ctccttgctg agtgcaaata ggaatttaaa tgtgaatttg aagtcaaagt tctcacttcc
     6121 agctaactgg caacatttat ttcctgagct gaagtcttgg agtaaaatac attccagtag
     6181 catctaccat ccaccattaa ttgctatgga agcctcattg tgtaccccac tcttctgtct
     6241 ccctgttttc tgtaaaataa aaccctcttg ctaagtaatt taagtgtacg ttcttagaat
     6301 acttaagtcc caaactaaag aaaaggaata aaataaaatt aatattttcc caaatactag
     6361 ttttcttcaa taggccatca tggtgcctta ttgttaacaa caaatatttc taaaatgtct
     6421 caggcaggct gggcccatct ccgtggtaaa gagcttgcct gcctagcaca cttgagccct
     6481 gggtttgcag acctatcccc tgtgtcctct ccacagtgcg cccttccaca cgcgccttgt
     6541 taaaggcctt gctgcgtgtt tttctctgca ggtatccgct gtaaataaga atgaagtagg
     6601 ggccaaaacc tgaaaccaaa aatgaagcag ctccttgtag tcttagttcc tagtttgagc
     6661 tgtagctgac tgcttggctt cccgtgtatt attttatatt gtgcttttgt cattgttaat
     6721 ggtttggact ttaataagag aaatcccata gtttttaatg tcacaaaaat aagcctattt
     6781 gaacagtgta ttccagaaag caatatacta accaaagtga atgcttgtgt gtattgatac
     6841 ccttttcctc tctaacgcct caactgtcaa ggaactaaaa cctttaaaag cataggcatg
     6901 ctggcctgag gtaaacactg gtacagttag agcggaggca gcagcccccg gtgttcagca
     6961 cagcttgtct gatgtgttta tggccagagt gcagtattcg gcactggcta gtaccgctgc
     7021 ctgaccgaac tccactggga agtggtttgc ttaaacgcac atgtttcttt gttactcctg
     7081 accatgcttg gatgcagtgc ctagattgtg gctgctattt ttagttcgca tcatgacctt
     7141 gactgcggag tccagcctta ccctcttact tgacaacagt agcccttaaa ctgcagtggg
     7201 aagaaagaag aatttggtat gaaaattggt gagctctggc acttgagata aacaagaaga
     7261 aagttccaac ttgatgcctt aagccgctcc tgcccgaagc tctgaaggac taagttggca
     7321 gagatcctta ctttgatact actgcatttt ttgtagaatt gttacattga taataaaact
     7381 tgcctgctta acctcaa
//
LOCUS       NM_001107306            2233 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus armadillo repeat containing 6 (Armc6), mRNA.
ACCESSION   NM_001107306 XM_001071122 XM_224735
VERSION     NM_001107306.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 14, 2025 this sequence version replaced NM_001107306.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166821.1, SRR26643288.55430.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               JAXUCZ010000016.1  19225057-19225419
            364-490             JAXUCZ010000016.1  19228524-19228650
            491-573             JAXUCZ010000016.1  19230787-19230869
            574-1147            JAXUCZ010000016.1  19234614-19235187
            1148-1293           JAXUCZ010000016.1  19236360-19236505
            1294-1425           JAXUCZ010000016.1  19237363-19237494
            1426-1563           JAXUCZ010000016.1  19237958-19238095
            1564-2233           JAXUCZ010000016.1  19239327-19239996
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2233
                     /gene="Armc6"
                     /note="armadillo repeat containing 6"
                     /db_xref="GeneID:306352"
                     /db_xref="RGD:1306691"
     exon            1..363
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    229..231
                     /gene="Armc6"
                     /note="upstream in-frame stop codon"
     exon            364..490
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1776
                     /gene="Armc6"
                     /codon_start=1
                     /product="armadillo repeat-containing protein 6"
                     /protein_id="NP_001100776.2"
                     /db_xref="GeneID:306352"
                     /db_xref="RGD:1306691"
                     /translation="MASKRITQETFDAAVRENIEEFEMGAEEAIREAVEQFESQGVDL
                     SNIVKTVPKVSLDGLQEPTHDVLQALNDLQQALTGSQLQEVSAHLVRFCDQCKQQKAS
                     RYLAAQKGAYPILLAAWQLAATSDQGLLLQALNALAVLTDGQPDLLDTQGLHLLVATL
                     ARNAANTELTCCGIRCVRHVCLKHEQNRQGLVKAGVLPLLTAAITQHGQHADVVREAC
                     WALRVMTFDDDIRVPFGHAHEHAKMIVQENRGLKVLIEAARAFSDNPGVLSELCSTLS
                     RLAVRNEFCQEVIDLGGLGILVTLLADCNDHQDLVKQVLSALRAIAGNDDVKDAIVRA
                     GGTQSIVAAMTRHLASPQVCEQSCAALCVLALRKPENSRVIIEGGGALAALQAMKAHP
                     QEAGVQKQACMLIRNLVSRSQVFSKPILDLGAEELILQARAAHPDCEDVAKAALRDLG
                     CRVELRELWTGKKGNLAP"
     misc_feature    799..915
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    799..915
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    919..1047
                     /gene="Armc6"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    919..1047
                     /gene="Armc6"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    937..1041
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    937..1041
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1099..1203
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1099..1203
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    order(1174..1176,1186..1188,1198..1200,1303..1305,
                     1315..1317,1327..1329,1432..1434,1444..1446,1456..1458)
                     /gene="Armc6"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    order(1174..1176,1186..1188,1198..1200,1303..1305,
                     1315..1317,1327..1329,1432..1434,1444..1446,1456..1458)
                     /gene="Armc6"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    1225..1335
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1225..1335
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1351..1461
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1351..1461
                     /gene="Armc6"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     exon            491..573
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1147
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1293
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1425
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1563
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2233
                     /gene="Armc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacgcaagc gtcgaaagta gccatgttgg ctctttcacg caggcgcgtt gctgaattct
       61 cagggcagat tatacctagg tgaaaactat ctcttttaag gggaagcgac acctagaagg
      121 agcattgaga agactgcaag ggtttcaggc ccacacgtac tctgtgtctc cctttgcttt
      181 acctgtgctt gcggtcgccc tcgttgcccc gggaaggagc ctttcagctg aaggagggac
      241 gccgagccga ggcgacgcct ctgcgcttgc gcgtgtacag tggccggaag gagccaaagt
      301 aaagtcaagt ctccggtgac agctgcgagc cccacccttt ccccacgtgg ctgcgtagac
      361 ctggcagcca tggcttccaa gcgcatcacc caggaaacct ttgatgctgc agtgagggag
      421 aacattgagg agtttgagat gggcgctgag gaggccattc gagaggctgt ggagcagttt
      481 gaatcgcaag gggttgatct gagcaacatt gtgaagacag taccgaaagt atccttggat
      541 ggcctccagg agcccacaca tgatgtccta caggctctca atgatctgca gcaggccctg
      601 actggctctc agctccagga ggtgtctgcc catcttgtcc gtttctgtga ccagtgcaag
      661 cagcagaaag ccagccgcta cctggcagcc cagaaggggg cctacccaat cctcctggct
      721 gcttggcagc tggctgccac tagcgaccag ggtcttctgc tccaggctct caatgccctg
      781 gcagtgctga ctgatggcca acctgacctc ctggatactc agggcttgca tcttctcgtg
      841 gccacgctgg cacggaatgc tgccaacact gaactcacat gctgtgggat tcgctgtgtg
      901 cgccatgtct gcctaaagca tgaacagaat cggcagggct tggtgaaagc cggtgtgctg
      961 cccctgctca cggctgctat tacacagcat ggtcaacacg ccgatgtggt cagggaggcc
     1021 tgctgggcct tgcgggtcat gaccttcgat gatgatatca gagtgccctt tggccatgcc
     1081 cacgagcatg ccaagatgat tgttcaggag aacagaggcc tgaaggtgct cattgaggct
     1141 gccagagctt tctctgacaa cccgggggtc ctgagcgaac tctgcagcac tctgtcccgc
     1201 ctggctgttc ggaatgaatt ctgccaggag gttatagacc tcggaggcct tggcatcctt
     1261 gtgaccctgc tggctgactg caatgaccac caggacctcg tgaagcaagt gctcagtgcc
     1321 ctgagggcta tcgcaggcaa tgacgacgtg aaggatgcta ttgtgcgggc aggcggtact
     1381 cagtccatcg tagctgccat gacccggcac ctggccagcc cccaggtgtg tgagcaaagc
     1441 tgtgcagcac tctgtgttct ggccctgcgc aagccagaga acagccgggt cattatcgag
     1501 ggcggcgggg cactggctgc tctgcaggcc atgaaggcgc atccacagga ggctggtgtc
     1561 cagaaacagg cttgcatgct gatccgaaac ctggtgtccc gcagccaggt cttttccaag
     1621 cccatcctgg acctgggggc ggaggagctc attttgcaag cccgagctgc tcacccggac
     1681 tgtgaagatg tggccaaggc tgcactgcga gacctgggct gccgtgtgga gcttcgtgaa
     1741 ctgtggacag gaaagaaggg caacctggca ccgtgaccct ggctcagaga gctctgactc
     1801 caaaacatgg ggtggctatg ggccctgcct ctctgtcccc acacccagag cacaagtgtg
     1861 ttagcttagg gttgggggtg gggagaagca gtgatgacat ggaggcccac cgttcccagt
     1921 gccctttcga ccacagcctt tctcggcagc tttggggcaa agggcacatg gaactgcagt
     1981 gttctgtctg gagtttgggg cctctaccag ctggtgtccc ggcagagcca gcctgcaatc
     2041 tgggcaccac tccaagcagt tgatgaccct gctccttggg caggcgtcct gggtagaggt
     2101 gcttcagcca aggctaattc cctaagatcc acacggtgga aggagggagg tgactccttc
     2161 aaactgtcct ctgaactcca catgtgtgct atggtgcaca cacacatact aaataaagaa
     2221 gtgtaaattt aaa
//
LOCUS       NM_001134624            1128 bp    mRNA    linear   ROD 14-APR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 69 (Lrrc69),
            transcript variant 2, mRNA.
ACCESSION   NM_001134624 XM_001055887 XM_575777
VERSION     NM_001134624.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1128)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_001055887.1, XM_575777.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132301, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1128
                     /gene="Lrrc69"
                     /note="leucine rich repeat containing 69"
                     /db_xref="GeneID:500415"
                     /db_xref="RGD:1583733"
     exon            1..200
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1010
                     /gene="Lrrc69"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 69"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 69
                     isoform 2"
                     /protein_id="NP_001128096.1"
                     /db_xref="GeneID:500415"
                     /db_xref="RGD:1583733"
                     /translation="MTERLLLTALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDL
                     QNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGNRICRIAAGV
                     LDGLGDLVLLNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHI
                     NYNRITRIPEEIRFLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGF
                     QDLKLREFYCEGNPLFLKNPIFAPQPKDLWTLREIAARFVLSQLEEYNPLIMDAIECY
                     PEVKDKLSKAKKCAICRKPFLSEWLECVYFVPPSKEEELSCWSISEVEDSQKTF"
     misc_feature    <39..>716
                     /gene="Lrrc69"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <39..>716
                     /gene="Lrrc69"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    63..131
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    63..131
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    132..269
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    132..269
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    270..341
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    270..341
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    342..410
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    342..410
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    411..479
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    411..479
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    480..548
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    480..548
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    549..617
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    549..617
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    618..683
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    618..683
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            201..327
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            328..400
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            401..596
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            597..668
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            669..770
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            771..950
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1128
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttacctcttc aaaaatcatg actgagagat tattgctaac agcactgaag ggtggcaaga
       61 gcactaagat ccttactttg aatgggaaga agatgagcaa gatgccctca gcactggaaa
      121 aactgcctaa tctgaggact ctagaccttc agaataatca aatctccaaa gtatgccctg
      181 agctaaggac cttgaccaag ttgacattac taaatctggg aaacaacctt ttacaagaag
      241 ttcctgaaga gataaaatac cttacctccc tgaagaatct tcatttattt ggaaacagga
      301 tttgcagaat tgctgctgga gtccttgatg gcctgggaga cttggttcta cttaatctga
      361 atgacaacca acttagcagt cttcctccag aaattggcag attacagaat ctcaccttcc
      421 taagcctcaa ccataacaag ctcaccgtga ttcccaaaga gatctgtttc cttgaacatc
      481 tttcggaact tcatattaac tacaatcgga tcacgcgcat ccctgaggag atcaggttcc
      541 tacagaacct tcagcagctt tctctggtca ggaacaacat cgaagagttg ccagaggaag
      601 tttgtcagct tacaaaacta ggagtcctgg acgtagctgg aaatgtaatc cagatatttc
      661 cagcaggctt tcaggatcta aagctgaggg aattctactg tgagggaaac ccactcttcc
      721 tgaagaatcc aatttttgct ccacaaccta aagatctctg gactctacgg gaaatagcag
      781 caagatttgt cctctctcaa ttagaagaat acaacccttt gattatggat gccatagagt
      841 gttacccaga ggtcaaggac aaactctcca aagcaaaaaa atgtgcaata tgcagaaaac
      901 cttttttatc tgagtggctg gaatgcgttt actttgttcc tccatcgaag gaagaagagc
      961 tctcctgttg gtccatatct gaagtggaag acagtcagaa aaccttttga tgtctatagg
     1021 tgttcgctgg acattcaagg ctgagatggt ccatgtgggt ggtatacatt attgaacatc
     1081 aaagagcctt cagtcactgg aactttcaaa taaatgttat taatctta
//
LOCUS       NM_001438097            3791 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 3, mRNA.
ACCESSION   NM_001438097 XM_039081900
VERSION     NM_001438097.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3791)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039081900.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.294242.1,
                                           SRR26643295.1796.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-312             JAXUCZ010000001.1  94931937-94932148   c
            313-403             JAXUCZ010000001.1  94931143-94931233   c
            404-571             JAXUCZ010000001.1  94930658-94930825   c
            572-699             JAXUCZ010000001.1  94928181-94928308   c
            700-803             JAXUCZ010000001.1  94928000-94928103   c
            804-886             JAXUCZ010000001.1  94926045-94926127   c
            887-1041            JAXUCZ010000001.1  94925808-94925962   c
            1042-1220           JAXUCZ010000001.1  94923695-94923873   c
            1221-2136           JAXUCZ010000001.1  94922695-94923610   c
            2137-2218           JAXUCZ010000001.1  94922525-94922606   c
            2219-3791           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3791
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            101..312
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    282..284
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            313..403
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..2360
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 1 is encoded by transcript variant 3;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 1"
                     /protein_id="NP_001425026.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNS
                     AMLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNP
                     DSNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGA
                     GDGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSG
                     PSPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPIS
                     APQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSAS
                     SRQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAK
                     VPPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGA
                     GDALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQK
                     RNVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <999..1886
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <999..1886
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2106..>2240
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2106..>2240
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            404..571
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            572..699
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            700..803
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            804..886
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1041
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1220
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..2136
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2218
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..3791
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tgcaaagaag actcaatagt
      121 gtggagaagt ctgtttcctg acattctgat tctgttagcc tggagtggga accgggaaga
      181 gcctacgggt gtgcttgggt ataccaaccc actctggcac atcaagtcac tgcaggacta
      241 ggccagtcct ctcccactga ggccaggcaa ggcagcccag ttaaggaaac gggatccaca
      301 gacaggcagc agtcagtttt cacctcccaa gacagccctt ggaaatgttc cccaaggtgg
      361 acaacccttt agaccatcaa gaagccagaa ctggagccac aaggtctcaa aagccacaag
      421 ctcccaaggc cacagcagcc aattctgctg agctgtctga ggagtcctgg ccatccagtt
      481 cagggaccgc ttccccaccc agtaccactg agggacagag tacctctcca cccctcacct
      541 taattgacaa cgaggactca gtggtggcca agtacataaa ccggttccgc aaagctcagc
      601 ccacgagccg agaggaccgc cagcccgtgg gcccaacccc agctgacttt tggtggctac
      661 agcctgcgtc ttcagacctc agcagtcacc ttgcagcagc aggagctggt gaacctacag
      721 gaagatctgc cgtgacaggt ccatgtccca ccgggatgtc cagtacgtct ctggcttctg
      781 tgcctcttca gagagtaaag cagagtctga actcttggaa ctcggctatg ctggagctgg
      841 agaccctgag ccttcaaagc cgagcggcca agctgctgga acgcagcaag gcctccctct
      901 cctcctcctc ctcctccccc agtcccaacg aagccagcag ctcctccttc cccatcagct
      961 ctgacggcct ctctccctgc tctgtgacct tcaatccgga ctccaacaag agttctagtc
     1021 ccaaagaacc cgtgctggga gcagccccag tgccatccca ggccatccct gcaccccgcc
     1081 cagcctctgc ccaggcaacc cttaagcctg aggaagacat tttataccaa tggaggcaac
     1141 ggaggaagct tgagcagtct ctacaaggtg caggtgatgg aacctgggtg ttgcctcgga
     1201 caccagccct cactactcag actcctgtct ctgcagtgaa tcttggttcc aaggggaccc
     1261 aacctaactg tgctccacca tggggcagtg tggcccagcc tcctccccca caggcattct
     1321 atatggagag gccacctctt tcagggccct ctccacacat ctgggccccc ggcacacacg
     1381 gggttctctg ggccccacag gccaatccct ggatacctct tgggatggtt cctaccacac
     1441 tgctaacctc cacccttgct cccttggcct ccttaccagt accacctacc tccacttcag
     1501 ctgccacagc ccccatctct gctccccagg tctccatccc agggccccca gcctctgccc
     1561 cacctccctg cacttctgcc ccagcttcca ccgtcccact acctgacaac ccccagggac
     1621 caaccacccc tgagttgagt agctctgtcc atcccaagaa gctgagcccc aagcctcgct
     1681 gtgtgagcgc ttcgtctcgt caggagacta ctggaccaga cactgcagct ttcgagagtc
     1741 cctgttctca gcttaggggg gctctgagcc aggtagtgac agctcggctg ttctccgaca
     1801 gcctggagga tatgcctcca tctgaagcag attcccggaa agtcaaggcc acctcctctc
     1861 aagccaaagt tccgccccct ccacctgagt cccggcgtgg gtccaagaca gagtcccgca
     1921 aaagtaaagt caccctctca gctgaagctg gggatccaca gccggctaca gccccaaagg
     1981 catccacact gtcagaggtc caatcacttg aattcaagaa gtctacaccc aagaagggag
     2041 ctggtgacgc cttgactacg gccccgcctg cctcaagcca cgccccttcc gaggacttgc
     2101 tatcccaggc cgctagactt ctgcaggctg cggaagactc tgacggcagc gagtttccgg
     2161 aagactctgt gttgcgagtg ctaagggctc agagggcaga actaaggcag cagaaaagga
     2221 atgtggatgc ccaattatcc ctcctcttgg accacactga agacccagga ttttcatctc
     2281 ctccagccag gtcaccttcc agttccccaa gaatgcggtt aaggagggaa ggagcctccc
     2341 ttgaggccag acgaccttga atcataaaca ttgtttttcc tgggctgggg aggtggctca
     2401 gtgggtaaag cacttgcaag tgtgaagacc cgagtttaga tccccagaac ccacataaag
     2461 gtaactgaca ggccagctgg tccatggaga cagggtctca atcaaggtgg aaatcaaaga
     2521 ccaatctctg aaattctctg acttccacac aagagctgtg gggtgtggtg cacataacac
     2581 aggcacgcac acacaggcac acacacacac ggacgcacac atgcgctcgc gcacgcacac
     2641 acacacacac acacacatac acaggcacac acactaaagt tgtccccaat taatattttt
     2701 ccagtttact gttaatctct aagaaatggg ttgttgtaga aaggctgatt gtgctaataa
     2761 ggaaatgtag ctcttcccta actactgaaa caaagtttct tctctctagc cctccttccc
     2821 accccctctc tctgatatcc ctccccctct ctctccccgg gagcacatgg ctctaggtaa
     2881 tgtgggcacc tgacttatgc aactcagaag tggagttgga catctcagat ggagacaaag
     2941 gccctgttat gtggcactaa gaaacatcag tgttggacaa tacatctctc atctgagctg
     3001 gcatcctccc tctctgatgg ccgtctccct ccacgggctc acgatgcctc ggttcccaca
     3061 ggtgcccaga ttcctggtgt ttccccaagt tcgttctcct tcacattctt caagactgtg
     3121 ctctccctac tcaggaccaa agtccttcga cagttagcct gactcctccc cttccccaca
     3181 catagtcagg cgctgactcg gtttgcttta tagttcccca gaatccaact cctttccgct
     3241 gccctcgcct cagtctaggc ttcctcctac ctgtacagtt gaaggttcgc cattactata
     3301 aacacatctg ctccctcttt gatgcacttg ccacccaggg ggacagcctg tctcttctct
     3361 ttgaaactga gcttttcaac aaatgcacct gaaagcctga ggcctctgtc agaaacatgg
     3421 gttctgtcct cccgttcttt ttcttacttt ctgtgactca gatgcttttc agagtctgct
     3481 atgaaacctg attgctggac acggaaacac acacctgtaa tctcaggagt ctgaggccag
     3541 aggatctcac tctggggtca ccctcatagt gagtccctgt gttgaaaaaa agagtcatgg
     3601 ggctggagag atggctcagt ggttaagagc actgactgct cttccagagg tcctgagttc
     3661 aattcccagc aaccacatgg tggctcacaa ccatctgtaa tgggatctga tgccctcttc
     3721 tggtgtgtct gaagacaact acagtgtact tatatataat aaataaataa atctttaaaa
     3781 aagaaagaaa a
//
LOCUS       NM_001438098            3788 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 4, mRNA.
ACCESSION   NM_001438098 XM_006228772
VERSION     NM_001438098.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006228772.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1839068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000001.1  94933032-94933340   c
            310-400             JAXUCZ010000001.1  94931143-94931233   c
            401-568             JAXUCZ010000001.1  94930658-94930825   c
            569-696             JAXUCZ010000001.1  94928181-94928308   c
            697-800             JAXUCZ010000001.1  94928000-94928103   c
            801-883             JAXUCZ010000001.1  94926045-94926127   c
            884-1038            JAXUCZ010000001.1  94925808-94925962   c
            1039-1217           JAXUCZ010000001.1  94923695-94923873   c
            1218-2133           JAXUCZ010000001.1  94922695-94923610   c
            2134-2215           JAXUCZ010000001.1  94922525-94922606   c
            2216-3788           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3788
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..309
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    285..287
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            310..400
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2357
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 1 is encoded by transcript variant 4;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 1"
                     /protein_id="NP_001425027.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNS
                     AMLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNP
                     DSNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGA
                     GDGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSG
                     PSPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPIS
                     APQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSAS
                     SRQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAK
                     VPPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGA
                     GDALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQK
                     RNVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2103..>2237
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2103..>2237
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            401..568
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            569..696
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            697..800
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            801..883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1038
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1217
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2133
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2215
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..3788
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag gtgaggttgg tccgtctttc
      121 agtgaccaca ggaggccttg gggaaggcaa cacgggttta caagagcctg gagtctccgg
      181 cccaacctta cgagaactac aactcccaag atactaagca gtttggtcgc tccggcatct
      241 ctgactgacg tcttttgttc tttctgggtg ggcctaacgg agtctaaaag aaatttgaaa
      301 atttagttct cagttttcac ctcccaagac agcccttgga aatgttcccc aaggtggaca
      361 accctttaga ccatcaagaa gccagaactg gagccacaag gtctcaaaag ccacaagctc
      421 ccaaggccac agcagccaat tctgctgagc tgtctgagga gtcctggcca tccagttcag
      481 ggaccgcttc cccacccagt accactgagg gacagagtac ctctccaccc ctcaccttaa
      541 ttgacaacga ggactcagtg gtggccaagt acataaaccg gttccgcaaa gctcagccca
      601 cgagccgaga ggaccgccag cccgtgggcc caaccccagc tgacttttgg tggctacagc
      661 ctgcgtcttc agacctcagc agtcaccttg cagcagcagg agctggtgaa cctacaggaa
      721 gatctgccgt gacaggtcca tgtcccaccg ggatgtccag tacgtctctg gcttctgtgc
      781 ctcttcagag agtaaagcag agtctgaact cttggaactc ggctatgctg gagctggaga
      841 ccctgagcct tcaaagccga gcggccaagc tgctggaacg cagcaaggcc tccctctcct
      901 cctcctcctc ctcccccagt cccaacgaag ccagcagctc ctccttcccc atcagctctg
      961 acggcctctc tccctgctct gtgaccttca atccggactc caacaagagt tctagtccca
     1021 aagaacccgt gctgggagca gccccagtgc catcccaggc catccctgca ccccgcccag
     1081 cctctgccca ggcaaccctt aagcctgagg aagacatttt ataccaatgg aggcaacgga
     1141 ggaagcttga gcagtctcta caaggtgcag gtgatggaac ctgggtgttg cctcggacac
     1201 cagccctcac tactcagact cctgtctctg cagtgaatct tggttccaag gggacccaac
     1261 ctaactgtgc tccaccatgg ggcagtgtgg cccagcctcc tcccccacag gcattctata
     1321 tggagaggcc acctctttca gggccctctc cacacatctg ggcccccggc acacacgggg
     1381 ttctctgggc cccacaggcc aatccctgga tacctcttgg gatggttcct accacactgc
     1441 taacctccac ccttgctccc ttggcctcct taccagtacc acctacctcc acttcagctg
     1501 ccacagcccc catctctgct ccccaggtct ccatcccagg gcccccagcc tctgccccac
     1561 ctccctgcac ttctgcccca gcttccaccg tcccactacc tgacaacccc cagggaccaa
     1621 ccacccctga gttgagtagc tctgtccatc ccaagaagct gagccccaag cctcgctgtg
     1681 tgagcgcttc gtctcgtcag gagactactg gaccagacac tgcagctttc gagagtccct
     1741 gttctcagct taggggggct ctgagccagg tagtgacagc tcggctgttc tccgacagcc
     1801 tggaggatat gcctccatct gaagcagatt cccggaaagt caaggccacc tcctctcaag
     1861 ccaaagttcc gccccctcca cctgagtccc ggcgtgggtc caagacagag tcccgcaaaa
     1921 gtaaagtcac cctctcagct gaagctgggg atccacagcc ggctacagcc ccaaaggcat
     1981 ccacactgtc agaggtccaa tcacttgaat tcaagaagtc tacacccaag aagggagctg
     2041 gtgacgcctt gactacggcc ccgcctgcct caagccacgc cccttccgag gacttgctat
     2101 cccaggccgc tagacttctg caggctgcgg aagactctga cggcagcgag tttccggaag
     2161 actctgtgtt gcgagtgcta agggctcaga gggcagaact aaggcagcag aaaaggaatg
     2221 tggatgccca attatccctc ctcttggacc acactgaaga cccaggattt tcatctcctc
     2281 cagccaggtc accttccagt tccccaagaa tgcggttaag gagggaagga gcctcccttg
     2341 aggccagacg accttgaatc ataaacattg tttttcctgg gctggggagg tggctcagtg
     2401 ggtaaagcac ttgcaagtgt gaagacccga gtttagatcc ccagaaccca cataaaggta
     2461 actgacaggc cagctggtcc atggagacag ggtctcaatc aaggtggaaa tcaaagacca
     2521 atctctgaaa ttctctgact tccacacaag agctgtgggg tgtggtgcac ataacacagg
     2581 cacgcacaca caggcacaca cacacacgga cgcacacatg cgctcgcgca cgcacacaca
     2641 cacacacaca cacatacaca ggcacacaca ctaaagttgt ccccaattaa tatttttcca
     2701 gtttactgtt aatctctaag aaatgggttg ttgtagaaag gctgattgtg ctaataagga
     2761 aatgtagctc ttccctaact actgaaacaa agtttcttct ctctagccct ccttcccacc
     2821 ccctctctct gatatccctc cccctctctc tccccgggag cacatggctc taggtaatgt
     2881 gggcacctga cttatgcaac tcagaagtgg agttggacat ctcagatgga gacaaaggcc
     2941 ctgttatgtg gcactaagaa acatcagtgt tggacaatac atctctcatc tgagctggca
     3001 tcctccctct ctgatggccg tctccctcca cgggctcacg atgcctcggt tcccacaggt
     3061 gcccagattc ctggtgtttc cccaagttcg ttctccttca cattcttcaa gactgtgctc
     3121 tccctactca ggaccaaagt ccttcgacag ttagcctgac tcctcccctt ccccacacat
     3181 agtcaggcgc tgactcggtt tgctttatag ttccccagaa tccaactcct ttccgctgcc
     3241 ctcgcctcag tctaggcttc ctcctacctg tacagttgaa ggttcgccat tactataaac
     3301 acatctgctc cctctttgat gcacttgcca cccaggggga cagcctgtct cttctctttg
     3361 aaactgagct tttcaacaaa tgcacctgaa agcctgaggc ctctgtcaga aacatgggtt
     3421 ctgtcctccc gttctttttc ttactttctg tgactcagat gcttttcaga gtctgctatg
     3481 aaacctgatt gctggacacg gaaacacaca cctgtaatct caggagtctg aggccagagg
     3541 atctcactct ggggtcaccc tcatagtgag tccctgtgtt gaaaaaaaga gtcatggggc
     3601 tggagagatg gctcagtggt taagagcact gactgctctt ccagaggtcc tgagttcaat
     3661 tcccagcaac cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg
     3721 tgtgtctgaa gacaactaca gtgtacttat atataataaa taaataaatc tttaaaaaag
     3781 aaagaaaa
//
LOCUS       NM_001438096            4000 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 2, mRNA.
ACCESSION   NM_001438096 XM_039081899
VERSION     NM_001438096.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4000)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039081899.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3245440.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000001.1  94933032-94933340   c
            310-521             JAXUCZ010000001.1  94931937-94932148   c
            522-612             JAXUCZ010000001.1  94931143-94931233   c
            613-780             JAXUCZ010000001.1  94930658-94930825   c
            781-908             JAXUCZ010000001.1  94928181-94928308   c
            909-1012            JAXUCZ010000001.1  94928000-94928103   c
            1013-1095           JAXUCZ010000001.1  94926045-94926127   c
            1096-1250           JAXUCZ010000001.1  94925808-94925962   c
            1251-1429           JAXUCZ010000001.1  94923695-94923873   c
            1430-2345           JAXUCZ010000001.1  94922695-94923610   c
            2346-2427           JAXUCZ010000001.1  94922525-94922606   c
            2428-4000           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..4000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4000
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..309
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            310..521
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    491..493
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            522..612
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..2569
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 1 is encoded by transcript variant 2;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 1"
                     /protein_id="NP_001425025.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNS
                     AMLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNP
                     DSNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGA
                     GDGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSG
                     PSPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPIS
                     APQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSAS
                     SRQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAK
                     VPPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGA
                     GDALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQK
                     RNVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <1208..2095
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1208..2095
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2315..>2449
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2315..>2449
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            613..780
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            781..908
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1012
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1095
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1250
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1429
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..2345
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2427
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..4000
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag gtgaggttgg tccgtctttc
      121 agtgaccaca ggaggccttg gggaaggcaa cacgggttta caagagcctg gagtctccgg
      181 cccaacctta cgagaactac aactcccaag atactaagca gtttggtcgc tccggcatct
      241 ctgactgacg tcttttgttc tttctgggtg ggcctaacgg agtctaaaag aaatttgaaa
      301 atttagttct gcaaagaaga ctcaatagtg tggagaagtc tgtttcctga cattctgatt
      361 ctgttagcct ggagtgggaa ccgggaagag cctacgggtg tgcttgggta taccaaccca
      421 ctctggcaca tcaagtcact gcaggactag gccagtcctc tcccactgag gccaggcaag
      481 gcagcccagt taaggaaacg ggatccacag acaggcagca gtcagttttc acctcccaag
      541 acagcccttg gaaatgttcc ccaaggtgga caacccttta gaccatcaag aagccagaac
      601 tggagccaca aggtctcaaa agccacaagc tcccaaggcc acagcagcca attctgctga
      661 gctgtctgag gagtcctggc catccagttc agggaccgct tccccaccca gtaccactga
      721 gggacagagt acctctccac ccctcacctt aattgacaac gaggactcag tggtggccaa
      781 gtacataaac cggttccgca aagctcagcc cacgagccga gaggaccgcc agcccgtggg
      841 cccaacccca gctgactttt ggtggctaca gcctgcgtct tcagacctca gcagtcacct
      901 tgcagcagca ggagctggtg aacctacagg aagatctgcc gtgacaggtc catgtcccac
      961 cgggatgtcc agtacgtctc tggcttctgt gcctcttcag agagtaaagc agagtctgaa
     1021 ctcttggaac tcggctatgc tggagctgga gaccctgagc cttcaaagcc gagcggccaa
     1081 gctgctggaa cgcagcaagg cctccctctc ctcctcctcc tcctccccca gtcccaacga
     1141 agccagcagc tcctccttcc ccatcagctc tgacggcctc tctccctgct ctgtgacctt
     1201 caatccggac tccaacaaga gttctagtcc caaagaaccc gtgctgggag cagccccagt
     1261 gccatcccag gccatccctg caccccgccc agcctctgcc caggcaaccc ttaagcctga
     1321 ggaagacatt ttataccaat ggaggcaacg gaggaagctt gagcagtctc tacaaggtgc
     1381 aggtgatgga acctgggtgt tgcctcggac accagccctc actactcaga ctcctgtctc
     1441 tgcagtgaat cttggttcca aggggaccca acctaactgt gctccaccat ggggcagtgt
     1501 ggcccagcct cctcccccac aggcattcta tatggagagg ccacctcttt cagggccctc
     1561 tccacacatc tgggcccccg gcacacacgg ggttctctgg gccccacagg ccaatccctg
     1621 gatacctctt gggatggttc ctaccacact gctaacctcc acccttgctc ccttggcctc
     1681 cttaccagta ccacctacct ccacttcagc tgccacagcc cccatctctg ctccccaggt
     1741 ctccatccca gggcccccag cctctgcccc acctccctgc acttctgccc cagcttccac
     1801 cgtcccacta cctgacaacc cccagggacc aaccacccct gagttgagta gctctgtcca
     1861 tcccaagaag ctgagcccca agcctcgctg tgtgagcgct tcgtctcgtc aggagactac
     1921 tggaccagac actgcagctt tcgagagtcc ctgttctcag cttagggggg ctctgagcca
     1981 ggtagtgaca gctcggctgt tctccgacag cctggaggat atgcctccat ctgaagcaga
     2041 ttcccggaaa gtcaaggcca cctcctctca agccaaagtt ccgccccctc cacctgagtc
     2101 ccggcgtggg tccaagacag agtcccgcaa aagtaaagtc accctctcag ctgaagctgg
     2161 ggatccacag ccggctacag ccccaaaggc atccacactg tcagaggtcc aatcacttga
     2221 attcaagaag tctacaccca agaagggagc tggtgacgcc ttgactacgg ccccgcctgc
     2281 ctcaagccac gccccttccg aggacttgct atcccaggcc gctagacttc tgcaggctgc
     2341 ggaagactct gacggcagcg agtttccgga agactctgtg ttgcgagtgc taagggctca
     2401 gagggcagaa ctaaggcagc agaaaaggaa tgtggatgcc caattatccc tcctcttgga
     2461 ccacactgaa gacccaggat tttcatctcc tccagccagg tcaccttcca gttccccaag
     2521 aatgcggtta aggagggaag gagcctccct tgaggccaga cgaccttgaa tcataaacat
     2581 tgtttttcct gggctgggga ggtggctcag tgggtaaagc acttgcaagt gtgaagaccc
     2641 gagtttagat ccccagaacc cacataaagg taactgacag gccagctggt ccatggagac
     2701 agggtctcaa tcaaggtgga aatcaaagac caatctctga aattctctga cttccacaca
     2761 agagctgtgg ggtgtggtgc acataacaca ggcacgcaca cacaggcaca cacacacacg
     2821 gacgcacaca tgcgctcgcg cacgcacaca cacacacaca cacacataca caggcacaca
     2881 cactaaagtt gtccccaatt aatatttttc cagtttactg ttaatctcta agaaatgggt
     2941 tgttgtagaa aggctgattg tgctaataag gaaatgtagc tcttccctaa ctactgaaac
     3001 aaagtttctt ctctctagcc ctccttccca ccccctctct ctgatatccc tccccctctc
     3061 tctccccggg agcacatggc tctaggtaat gtgggcacct gacttatgca actcagaagt
     3121 ggagttggac atctcagatg gagacaaagg ccctgttatg tggcactaag aaacatcagt
     3181 gttggacaat acatctctca tctgagctgg catcctccct ctctgatggc cgtctccctc
     3241 cacgggctca cgatgcctcg gttcccacag gtgcccagat tcctggtgtt tccccaagtt
     3301 cgttctcctt cacattcttc aagactgtgc tctccctact caggaccaaa gtccttcgac
     3361 agttagcctg actcctcccc ttccccacac atagtcaggc gctgactcgg tttgctttat
     3421 agttccccag aatccaactc ctttccgctg ccctcgcctc agtctaggct tcctcctacc
     3481 tgtacagttg aaggttcgcc attactataa acacatctgc tccctctttg atgcacttgc
     3541 cacccagggg gacagcctgt ctcttctctt tgaaactgag cttttcaaca aatgcacctg
     3601 aaagcctgag gcctctgtca gaaacatggg ttctgtcctc ccgttctttt tcttactttc
     3661 tgtgactcag atgcttttca gagtctgcta tgaaacctga ttgctggaca cggaaacaca
     3721 cacctgtaat ctcaggagtc tgaggccaga ggatctcact ctggggtcac cctcatagtg
     3781 agtccctgtg ttgaaaaaaa gagtcatggg gctggagaga tggctcagtg gttaagagca
     3841 ctgactgctc ttccagaggt cctgagttca attcccagca accacatggt ggctcacaac
     3901 catctgtaat gggatctgat gccctcttct ggtgtgtctg aagacaacta cagtgtactt
     3961 atatataata aataaataaa tctttaaaaa agaaagaaaa
//
LOCUS       NM_001438086            2226 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 3, mRNA.
ACCESSION   NM_001438086 XM_039081742
VERSION     NM_001438086.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039081742.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1751427.1,
                                           SRR26360194.1254687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  88052773-88053076   c
            305-479             JAXUCZ010000001.1  88045950-88046124   c
            480-645             JAXUCZ010000001.1  88045709-88045874   c
            646-730             JAXUCZ010000001.1  88043417-88043501   c
            731-768             JAXUCZ010000001.1  88042666-88042703   c
            769-1010            JAXUCZ010000001.1  88042312-88042553   c
            1011-1111           JAXUCZ010000001.1  88042068-88042168   c
            1112-1163           JAXUCZ010000001.1  88040749-88040800   c
            1164-1197           JAXUCZ010000001.1  88040554-88040587   c
            1198-1243           JAXUCZ010000001.1  88040283-88040328   c
            1244-1334           JAXUCZ010000001.1  88040092-88040182   c
            1335-1392           JAXUCZ010000001.1  88038970-88039027   c
            1393-2226           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2226
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..304
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     CDS             300..1430
                     /gene="Vasp"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 3"
                     /protein_id="NP_001425015.1"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MSNETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPT
                     ANSFRVVGRKLQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQ
                     FAIGMANALEALEGGGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPP
                     APPAGGPPPPPGPPPPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGS
                     GAPGLAAAIAGAKLRKVSKQEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQ
                     VGEKPPKDESASEESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSS
                     SDDSDLERVKQELVEEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    945..1025
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    945..1025
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1317..1415
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1317..1415
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            305..479
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            646..730
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            731..768
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1010
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1111
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1163
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1197
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1243
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1334
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1392
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2226
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtagtaa gagtaaccgc gtaggtgctg ccggctgagg gggtgcgccg gcgaggttcg
       61 gacgctgcac cccgctttcc atcgcagggg atcccagcac atcagagcac cggagggagg
      121 aggcgcctga gcacccgccc gggcccggtc cacgttctcc ccaggaagct ggactctatg
      181 gggcgggacc ccgagagaga ctgagcagaa cctggagcca gccccgcacc cctgcacttc
      241 caatcagggg cgccccggga gcactccccg tgggcgcgcc gcctgccctc tgcgcagcca
      301 tgagcaacga gacggtcatt tgttccagcc gggctactgt gatgctttac gatgacagca
      361 acaaacgatg gcttcctgct ggcaccggtc cccaggcctt tagccgcgtc cagatctacc
      421 acaaccccac tgctaactct ttccgagttg ttggccgcaa gctgcagcct gaccagcagg
      481 tggttatcaa ctgtgccatc attcgaggtg tcaagtacaa tcaggccact cccatattcc
      541 accagtggcg tgatgcccgc caggtctggg gcctcaactt cggcagcaag gaggacgctg
      601 cgcagtttgc gatcggcatg gccaatgccc tggaggcctt ggaaggaggt gggcctcccc
      661 ctgccccagc accccctgcc tggtctaccc agaatggccc ctccccagag gagctggaac
      721 aacagaaaag gcagcctgaa catttggagc gccgggtctc caatgcagga ggcccacctg
      781 ctcccccagc tgggggccca cctccacctc caggacctcc ccctcctccg ggtccccccc
      841 cacccccagg tctgcccccc tcaggggtat ctggggcagg tcatggaaca ggtgtagccc
      901 caccccctgc acccccactc cctacagcac agggccccag tagtgggggt tccggggccc
      961 caggcctggc cgctgccatt gctggagcca aactcaggaa agtgagcaag caggaggagg
     1021 cctctggggg gcccctggcc cccaaagctg agaatagtcg aggcactggt ggggggctta
     1081 tggaagagat gaacgccatg ctggcccgga gaaggaaagc cacacaggtt ggggagaagc
     1141 cccccaaaga cgagtcagcc agtgaggagt cagaggcccg aatccctgcc caaagtgaac
     1201 ctgtgcgaag accctgggag aagaacagca caaccttgcc aaggatgaag tcatcctctt
     1261 ctgtgactac ctccgaggcc cacccctctg tgcccagctc cagtgatgac tccgacttgg
     1321 agagggtgaa gcaggagctt gtggaagagg tgcggaagga gctacagaaa atgaaagagg
     1381 aaataatcga agtctttgtc caggagctga ggaagcgggg ttctccttga ctacagggac
     1441 ccagaagacc catttcttct ttttgtactt cctgcctggc acctgctttc cctgcctcaa
     1501 cttgaccaag agttacacaa gaatgcgttc tcccctacca gctcccactt ggaagattcc
     1561 acaggggtgt ggcttcctgg tgccgtggtc acacccacgc tggctgctga ttggataagg
     1621 aggtcccacc cctttgttcc ctttggtcct tccccttcac catccccttg gagctggttc
     1681 ctctgctggg gatgtaagag taaccccaca gtaagggaag gaaggagggg atctcacctt
     1741 ctcttgttct ggattcactt taacgcttta atgccttgga attttttttt ttaagaaaaa
     1801 gtatatatat atatttgggt tttgtggggg gaagggaaat tttttgttct ctttggtttt
     1861 gataaaatgg ggtgtgggag tttttaaatg ctatacccca agctttgtcc catcagaggc
     1921 agctatgtaa gaggaggggt atcccaccaa gtagggggca tttcccccac ccctgggata
     1981 cctccccatt tgccttggct cctctctctt ttctataagg aattaagatt ctttaacttt
     2041 tttggaacct cagttttgtg gtttttttta tttgggttag gatttcaggg tccagaccat
     2101 ttttgccctc caggaagacg aagtgagggg gaggagaaga ggaaaaatag gtcctccgac
     2161 ttctacacca tagcttcttg gacacgggcc ctcgctgaat aaatctgcag tttttataaa
     2221 tgcaaa
//
LOCUS       NM_001438114            2959 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 2, mRNA.
ACCESSION   NM_001438114 XM_006228857
VERSION     NM_001438114.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2959)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2959)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2959)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2959)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2959)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2959)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006228857.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.2003.1,
                                           SRR26643298.2488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-856             JAXUCZ010000001.1  96116217-96116393   c
            857-922             JAXUCZ010000001.1  96115848-96115913   c
            923-1105            JAXUCZ010000001.1  96111458-96111640   c
            1106-1277           JAXUCZ010000001.1  96111181-96111352   c
            1278-1509           JAXUCZ010000001.1  96109086-96109317   c
            1510-1566           JAXUCZ010000001.1  96105606-96105662   c
            1567-2959           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2959
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2959
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1533
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 2 is encoded by transcript variant 2; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 2"
                     /protein_id="NP_001425043.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNG
                     EDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLN
                     AETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREF
                     ADFEYRKTTAFGP"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            857..922
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1105
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1277
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1509
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1566
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..2959
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagg tcgatcaagc cctcagttag accctttgag aaaaagtcca
      721 accatggaac aagcagtgca gaccgcctcg gcccacttac ctgctccagc acctgttggg
      781 agaaggagcc ctgtacccgc caggcctttg ccacctacca gccagaaagc aatagacaac
      841 caagagcaca ggcgagctga agttcacaaa gtcccaaggc cagaaaatga gcaactcaga
      901 aatgacagca agaggcaagt agttcctgga gttccttctg ctccaagaag aggacgtggg
      961 ggtcatcgag gtggcagggg aagatttggt attcgtcgag atggtccaat gaaatttgag
     1021 aaagactttg actttgaaag tgcaaatgca caatttaaca aggaggaaat cgacagagag
     1081 tttcataata aacttaaatt aaaagaagat aaacttgaga aacaagagaa acctgtaaac
     1141 ggtgaagaca aaggagactc gggagttgat acccagaaca gcgaggggaa tgctgatgag
     1201 gaagatcccc ttgggcccaa ctgctactac gacaaaacca aatccttctt cgacaacatc
     1261 tcttgtgatg ataatagaga aaggagacca acttgggctg aagaaagaag gttaaatgct
     1321 gaaacttttg gaatcccact tcgtccaaat cgtggccgtg ggggttaccg aggcagagga
     1381 ggccttggct tccgtggtgg cagaggacgt ggtagtggcc gaggaggaac cttcactgcc
     1441 cctcgagggt ttcgtgctgg attcagaggc gctcgtgggg gtagggagtt tgcagatttt
     1501 gaatatagga aaaccacggc ttttggaccc taaaaggtct ggattggtca tactgctttc
     1561 tgaaagaaag acaacaaagt tgctgcatag tctacaaaca agtctctgaa cataggtgac
     1621 tcctagctct tcatggtcct ggaaagtggt tcggtctttg tgaagaatga agaagtgaag
     1681 ttgctgtctg tctgtcacca gcactgggtt ttgtctgttt tctgcttcac gtcaaagcta
     1741 tactgcagtt gctttggggc aggaaggctc gtcttaaaac acaagcataa gtgtgtgtgg
     1801 agtagcaggt tatgattcct tgcttagagt tgaactaaag ccagctaaat ggaattgcta
     1861 agtgtttttt cttcaatgaa aggatttttc ttatcactaa ttaattgtat tcggcaatta
     1921 ctttgagttg cctgcagata ggccgtgata ctgtgttttg agccacagaa agttttgtgt
     1981 gtgtgcgcgc gcgcgcgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtacgt gtgtgtccca
     2041 taatatgagg tagcttattt cgacacttaa ttagggtgct ggatggtaga gaattttgtc
     2101 agtcaactat gtacacacag gtaaatactg tttcttaggc aaaggtaact tttttatata
     2161 gttgtaaaat tccattatat tccattgcca aagaaacatt aagaactttg tatagctgta
     2221 taaaaagcaa ctaatttttt aaagaataaa cgttttaaag tcagcaaaca tacgtgtcct
     2281 tgcagaagtc agtgtgctga ggagcaggga tatgggtggg tctttttccc cttgctttcc
     2341 aggcttaagg ttttttattt cctttgtaat gtttggaaca caaatgaaga tttgataact
     2401 ttattccatt atctaaaaag cataaattat tcatgcatag tgtatggact tcgttttgta
     2461 gcaaatcaca ggatttgttc aaataacaga tattttaagt gtgtgaatgt aaataatcat
     2521 agatgagaat gtaccttgct gtattttcaa ataagtaacc ttctcctttt taagacatta
     2581 agactcgttg atctatcagt tgacccgctc ctcctgctat gcctggaatt ctgttgtggt
     2641 aatgctgact cctgttttcc atcaaaaaga tggagttttc agaatcatct ggcacctgta
     2701 aaacatcact aacatagtgt gtaggcctgc ggcctaccga tgactctgta cacgtttgtt
     2761 gctaactgta aattactaat aaatcttttt tgatatttaa gctatagtgg aaaaagatct
     2821 ggccactttg tgtttttaat aaaggccatg gaataaaggg atccaaagat ttcaatattt
     2881 ttaactatat tggcttttgt taactttctc aataaaacat tgagtagtga tagacgtgtg
     2941 ggaaactgca ctgtaggag
//
LOCUS       NM_001438118            2782 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 6, mRNA.
ACCESSION   NM_001438118 XM_017589354
VERSION     NM_001438118.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_017589354.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1236.1,
                                           SRR26643292.1838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-745             JAXUCZ010000001.1  96115848-96115913   c
            746-928             JAXUCZ010000001.1  96111458-96111640   c
            929-1100            JAXUCZ010000001.1  96111181-96111352   c
            1101-1332           JAXUCZ010000001.1  96109086-96109317   c
            1333-1389           JAXUCZ010000001.1  96105606-96105662   c
            1390-2782           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2782
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1356
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 6 is encoded by transcript variant 6; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 6"
                     /protein_id="NP_001425047.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHRG
                     GRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGE
                     DKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNA
                     ETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFA
                     DFEYRKTTAFGP"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    832..1164
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    832..1164
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..745
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            746..928
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1100
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1332
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1389
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..2782
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagc tgaagttcac aaagtcccaa ggccagaaaa tgagcaactc
      721 agaaatgaca gcaagaggca agtagttcct ggagttcctt ctgctccaag aagaggacgt
      781 gggggtcatc gaggtggcag gggaagattt ggtattcgtc gagatggtcc aatgaaattt
      841 gagaaagact ttgactttga aagtgcaaat gcacaattta acaaggagga aatcgacaga
      901 gagtttcata ataaacttaa attaaaagaa gataaacttg agaaacaaga gaaacctgta
      961 aacggtgaag acaaaggaga ctcgggagtt gatacccaga acagcgaggg gaatgctgat
     1021 gaggaagatc cccttgggcc caactgctac tacgacaaaa ccaaatcctt cttcgacaac
     1081 atctcttgtg atgataatag agaaaggaga ccaacttggg ctgaagaaag aaggttaaat
     1141 gctgaaactt ttggaatccc acttcgtcca aatcgtggcc gtgggggtta ccgaggcaga
     1201 ggaggccttg gcttccgtgg tggcagagga cgtggtagtg gccgaggagg aaccttcact
     1261 gcccctcgag ggtttcgtgc tggattcaga ggcgctcgtg ggggtaggga gtttgcagat
     1321 tttgaatata ggaaaaccac ggcttttgga ccctaaaagg tctggattgg tcatactgct
     1381 ttctgaaaga aagacaacaa agttgctgca tagtctacaa acaagtctct gaacataggt
     1441 gactcctagc tcttcatggt cctggaaagt ggttcggtct ttgtgaagaa tgaagaagtg
     1501 aagttgctgt ctgtctgtca ccagcactgg gttttgtctg ttttctgctt cacgtcaaag
     1561 ctatactgca gttgctttgg ggcaggaagg ctcgtcttaa aacacaagca taagtgtgtg
     1621 tggagtagca ggttatgatt ccttgcttag agttgaacta aagccagcta aatggaattg
     1681 ctaagtgttt tttcttcaat gaaaggattt ttcttatcac taattaattg tattcggcaa
     1741 ttactttgag ttgcctgcag ataggccgtg atactgtgtt ttgagccaca gaaagttttg
     1801 tgtgtgtgcg cgcgcgcgcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta cgtgtgtgtc
     1861 ccataatatg aggtagctta tttcgacact taattagggt gctggatggt agagaatttt
     1921 gtcagtcaac tatgtacaca caggtaaata ctgtttctta ggcaaaggta acttttttat
     1981 atagttgtaa aattccatta tattccattg ccaaagaaac attaagaact ttgtatagct
     2041 gtataaaaag caactaattt tttaaagaat aaacgtttta aagtcagcaa acatacgtgt
     2101 ccttgcagaa gtcagtgtgc tgaggagcag ggatatgggt gggtcttttt ccccttgctt
     2161 tccaggctta aggtttttta tttcctttgt aatgtttgga acacaaatga agatttgata
     2221 actttattcc attatctaaa aagcataaat tattcatgca tagtgtatgg acttcgtttt
     2281 gtagcaaatc acaggatttg ttcaaataac agatatttta agtgtgtgaa tgtaaataat
     2341 catagatgag aatgtacctt gctgtatttt caaataagta accttctcct ttttaagaca
     2401 ttaagactcg ttgatctatc agttgacccg ctcctcctgc tatgcctgga attctgttgt
     2461 ggtaatgctg actcctgttt tccatcaaaa agatggagtt ttcagaatca tctggcacct
     2521 gtaaaacatc actaacatag tgtgtaggcc tgcggcctac cgatgactct gtacacgttt
     2581 gttgctaact gtaaattact aataaatctt ttttgatatt taagctatag tggaaaaaga
     2641 tctggccact ttgtgttttt aataaaggcc atggaataaa gggatccaaa gatttcaata
     2701 tttttaacta tattggcttt tgttaacttt ctcaataaaa cattgagtag tgatagacgt
     2761 gtgggaaact gcactgtagg ag
//
LOCUS       NM_001438104            3784 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 9, mRNA.
ACCESSION   NM_001438104 XM_063266457
VERSION     NM_001438104.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3784)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266457.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2441413.1,
                                           SRR26360181.3287243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-312             JAXUCZ010000001.1  94931937-94932148   c
            313-399             JAXUCZ010000001.1  94931143-94931229   c
            400-567             JAXUCZ010000001.1  94930658-94930825   c
            568-695             JAXUCZ010000001.1  94928181-94928308   c
            696-796             JAXUCZ010000001.1  94928000-94928100   c
            797-879             JAXUCZ010000001.1  94926045-94926127   c
            880-1034            JAXUCZ010000001.1  94925808-94925962   c
            1035-1213           JAXUCZ010000001.1  94923695-94923873   c
            1214-2129           JAXUCZ010000001.1  94922695-94923610   c
            2130-2211           JAXUCZ010000001.1  94922525-94922606   c
            2212-3784           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3784
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3784
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            101..312
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    239..241
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            313..399
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..2353
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 9;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425033.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <992..1879
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <992..1879
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2099..>2233
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2099..>2233
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            400..567
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            568..695
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            696..796
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            797..879
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1034
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1213
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2129
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2211
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..3784
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tgcaaagaag actcaatagt
      121 gtggagaagt ctgtttcctg acattctgat tctgttagcc tggagtggga accgggaaga
      181 gcctacgggt gtgcttgggt ataccaaccc actctggcac atcaagtcac tgcaggacta
      241 ggccagtcct ctcccactga ggccaggcaa ggcagcccag ttaaggaaac gggatccaca
      301 gacaggcagc agttttcacc tcccaagaca gcccttggaa atgttcccca aggtggacaa
      361 ccctttagac catcaagaag ccagaactgg agccacaagg tctcaaaagc cacaagctcc
      421 caaggccaca gcagccaatt ctgctgagct gtctgaggag tcctggccat ccagttcagg
      481 gaccgcttcc ccacccagta ccactgaggg acagagtacc tctccacccc tcaccttaat
      541 tgacaacgag gactcagtgg tggccaagta cataaaccgg ttccgcaaag ctcagcccac
      601 gagccgagag gaccgccagc ccgtgggccc aaccccagct gacttttggt ggctacagcc
      661 tgcgtcttca gacctcagca gtcaccttgc agcaggagct ggtgaaccta caggaagatc
      721 tgccgtgaca ggtccatgtc ccaccgggat gtccagtacg tctctggctt ctgtgcctct
      781 tcagagagta aagcagagtc tgaactcttg gaactcggct atgctggagc tggagaccct
      841 gagccttcaa agccgagcgg ccaagctgct ggaacgcagc aaggcctccc tctcctcctc
      901 ctcctcctcc cccagtccca acgaagccag cagctcctcc ttccccatca gctctgacgg
      961 cctctctccc tgctctgtga ccttcaatcc ggactccaac aagagttcta gtcccaaaga
     1021 acccgtgctg ggagcagccc cagtgccatc ccaggccatc cctgcacccc gcccagcctc
     1081 tgcccaggca acccttaagc ctgaggaaga cattttatac caatggaggc aacggaggaa
     1141 gcttgagcag tctctacaag gtgcaggtga tggaacctgg gtgttgcctc ggacaccagc
     1201 cctcactact cagactcctg tctctgcagt gaatcttggt tccaagggga cccaacctaa
     1261 ctgtgctcca ccatggggca gtgtggccca gcctcctccc ccacaggcat tctatatgga
     1321 gaggccacct ctttcagggc cctctccaca catctgggcc cccggcacac acggggttct
     1381 ctgggcccca caggccaatc cctggatacc tcttgggatg gttcctacca cactgctaac
     1441 ctccaccctt gctcccttgg cctccttacc agtaccacct acctccactt cagctgccac
     1501 agcccccatc tctgctcccc aggtctccat cccagggccc ccagcctctg ccccacctcc
     1561 ctgcacttct gccccagctt ccaccgtccc actacctgac aacccccagg gaccaaccac
     1621 ccctgagttg agtagctctg tccatcccaa gaagctgagc cccaagcctc gctgtgtgag
     1681 cgcttcgtct cgtcaggaga ctactggacc agacactgca gctttcgaga gtccctgttc
     1741 tcagcttagg ggggctctga gccaggtagt gacagctcgg ctgttctccg acagcctgga
     1801 ggatatgcct ccatctgaag cagattcccg gaaagtcaag gccacctcct ctcaagccaa
     1861 agttccgccc cctccacctg agtcccggcg tgggtccaag acagagtccc gcaaaagtaa
     1921 agtcaccctc tcagctgaag ctggggatcc acagccggct acagccccaa aggcatccac
     1981 actgtcagag gtccaatcac ttgaattcaa gaagtctaca cccaagaagg gagctggtga
     2041 cgccttgact acggccccgc ctgcctcaag ccacgcccct tccgaggact tgctatccca
     2101 ggccgctaga cttctgcagg ctgcggaaga ctctgacggc agcgagtttc cggaagactc
     2161 tgtgttgcga gtgctaaggg ctcagagggc agaactaagg cagcagaaaa ggaatgtgga
     2221 tgcccaatta tccctcctct tggaccacac tgaagaccca ggattttcat ctcctccagc
     2281 caggtcacct tccagttccc caagaatgcg gttaaggagg gaaggagcct cccttgaggc
     2341 cagacgacct tgaatcataa acattgtttt tcctgggctg gggaggtggc tcagtgggta
     2401 aagcacttgc aagtgtgaag acccgagttt agatccccag aacccacata aaggtaactg
     2461 acaggccagc tggtccatgg agacagggtc tcaatcaagg tggaaatcaa agaccaatct
     2521 ctgaaattct ctgacttcca cacaagagct gtggggtgtg gtgcacataa cacaggcacg
     2581 cacacacagg cacacacaca cacggacgca cacatgcgct cgcgcacgca cacacacaca
     2641 cacacacaca tacacaggca cacacactaa agttgtcccc aattaatatt tttccagttt
     2701 actgttaatc tctaagaaat gggttgttgt agaaaggctg attgtgctaa taaggaaatg
     2761 tagctcttcc ctaactactg aaacaaagtt tcttctctct agccctcctt cccaccccct
     2821 ctctctgata tccctccccc tctctctccc cgggagcaca tggctctagg taatgtgggc
     2881 acctgactta tgcaactcag aagtggagtt ggacatctca gatggagaca aaggccctgt
     2941 tatgtggcac taagaaacat cagtgttgga caatacatct ctcatctgag ctggcatcct
     3001 ccctctctga tggccgtctc cctccacggg ctcacgatgc ctcggttccc acaggtgccc
     3061 agattcctgg tgtttcccca agttcgttct ccttcacatt cttcaagact gtgctctccc
     3121 tactcaggac caaagtcctt cgacagttag cctgactcct ccccttcccc acacatagtc
     3181 aggcgctgac tcggtttgct ttatagttcc ccagaatcca actcctttcc gctgccctcg
     3241 cctcagtcta ggcttcctcc tacctgtaca gttgaaggtt cgccattact ataaacacat
     3301 ctgctccctc tttgatgcac ttgccaccca gggggacagc ctgtctcttc tctttgaaac
     3361 tgagcttttc aacaaatgca cctgaaagcc tgaggcctct gtcagaaaca tgggttctgt
     3421 cctcccgttc tttttcttac tttctgtgac tcagatgctt ttcagagtct gctatgaaac
     3481 ctgattgctg gacacggaaa cacacacctg taatctcagg agtctgaggc cagaggatct
     3541 cactctgggg tcaccctcat agtgagtccc tgtgttgaaa aaaagagtca tggggctgga
     3601 gagatggctc agtggttaag agcactgact gctcttccag aggtcctgag ttcaattccc
     3661 agcaaccaca tggtggctca caaccatctg taatgggatc tgatgccctc ttctggtgtg
     3721 tctgaagaca actacagtgt acttatatat aataaataaa taaatcttta aaaaagaaag
     3781 aaaa
//
LOCUS       NM_001044267            1927 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus MAPK interacting serine/threonine kinase 1
            (Mknk1), transcript variant 2, mRNA.
ACCESSION   NM_001044267 XM_001064399 XM_001064462 XM_575887
VERSION     NM_001044267.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Panja,D., Kenney,J.W., D'Andrea,L., Zalfa,F., Vedeler,A.,
            Wibrand,K., Fukunaga,R., Bagni,C., Proud,C.G. and Bramham,C.R.
  TITLE     Two-stage translational control of dentate gyrus LTP consolidation
            is mediated by sustained BDNF-TrkB signaling to MNK
  JOURNAL   Cell Rep 9 (4), 1430-1445 (2014)
   PUBMED   25453757
  REMARK    GeneRIF: Long-term potentiation (LTP) consolidation in the dentate
            gyrus of live rodents requires sustained (hours) BDNF-TrkB
            signaling and from TrkB to MAP-kinase-interacting kinase.
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Niknami,M., Patel,M., Witting,P.K. and Dong,Q.
  TITLE     Molecules in focus: cytosolic phospholipase A2-alpha
  JOURNAL   Int J Biochem Cell Biol 41 (5), 994-997 (2009)
   PUBMED   18761105
  REMARK    Review article
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Chrestensen,C.A., Eschenroeder,A., Ross,W.G., Ueda,T.,
            Watanabe-Fukunaga,R., Fukunaga,R. and Sturgill,T.W.
  TITLE     Loss of MNK function sensitizes fibroblasts to serum-withdrawal
            induced apoptosis
  JOURNAL   Genes Cells 12 (10), 1133-1140 (2007)
   PUBMED   17903173
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Origanti,S. and Shantz,L.M.
  TITLE     Ras transformation of RIE-1 cells activates cap-independent
            translation of ornithine decarboxylase: regulation by the
            Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways
  JOURNAL   Cancer Res 67 (10), 4834-4842 (2007)
   PUBMED   17510413
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Chen,S., Atkins,C.M., Liu,C.L., Alonso,O.F., Dietrich,W.D. and
            Hu,B.R.
  TITLE     Alterations in mammalian target of rapamycin signaling pathways
            after traumatic brain injury
  JOURNAL   J Cereb Blood Flow Metab 27 (5), 939-949 (2007)
   PUBMED   16955078
REFERENCE   6  (bases 1 to 1927)
  AUTHORS   Chrestensen,C.A., Shuman,J.K., Eschenroeder,A., Worthington,M.,
            Gram,H. and Sturgill,T.W.
  TITLE     MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines
  JOURNAL   J Biol Chem 282 (7), 4243-4252 (2007)
   PUBMED   17130135
REFERENCE   7  (bases 1 to 1927)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   8  (bases 1 to 1927)
  AUTHORS   Fukunaga,R. and Hunter,T.
  TITLE     MNK1, a new MAP kinase-activated protein kinase, isolated by a
            novel expression screening method for identifying protein kinase
            substrates
  JOURNAL   EMBO J 16 (8), 1921-1933 (1997)
   PUBMED   9155018
REFERENCE   9  (bases 1 to 1927)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001044267.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098754.1, SRR26360194.418492.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000005.1  134554954-134555014
            62-163              JAXUCZ010000005.1  134571567-134571668
            164-261             JAXUCZ010000005.1  134574492-134574589
            262-341             JAXUCZ010000005.1  134578205-134578284
            342-415             JAXUCZ010000005.1  134579770-134579843
            416-520             JAXUCZ010000005.1  134581684-134581788
            521-576             JAXUCZ010000005.1  134585673-134585728
            577-672             JAXUCZ010000005.1  134588565-134588660
            673-867             JAXUCZ010000005.1  134590071-134590265
            868-1032            JAXUCZ010000005.1  134590831-134590995
            1033-1076           JAXUCZ010000005.1  134592000-134592043
            1077-1927           JAXUCZ010000005.1  134593119-134593969
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1927
                     /gene="Mknk1"
                     /note="MAPK interacting serine/threonine kinase 1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
     exon            1..61
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    58..60
                     /gene="Mknk1"
                     /note="upstream in-frame stop codon"
     exon            62..163
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1305
                     /gene="Mknk1"
                     /EC_number="2.7.11.1"
                     /note="mnk1; MAP kinase signal-integrating kinase 1; MAPK
                     signal-integrating kinase 1; MAP kinase-interacting
                     serine/threonine kinase 1"
                     /codon_start=1
                     /product="MAP kinase-interacting serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_001037732.1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
                     /translation="MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLG
                     EGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFF
                     EDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTKGIAHRDLK
                     PENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF
                     RDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQ
                     EGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQ
                     VLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEHEALAEGLCSMKLSPPSKSRLA
                     RRRALAHAGREANSCSTPAGL"
     misc_feature    64..141
                     /gene="Mknk1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4G050.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    127..129
                     /gene="Mknk1"
                     /note="Phosphothreonine, by PAK2.
                     /evidence=ECO:0000250|UniProtKB:O08605; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    142..144
                     /gene="Mknk1"
                     /note="Phosphoserine, by PAK2.
                     /evidence=ECO:0000250|UniProtKB:O08605; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    163..1029
                     /gene="Mknk1"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Mitogen-activated protein kinase signal-integrating kinase
                     1; Region: STKc_Mnk1; cd14174"
                     /db_xref="CDD:271076"
     misc_feature    163..1029
                     /gene="Mknk1"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Mitogen-activated protein kinase signal-integrating kinase
                     1; Region: STKc_Mnk1; cd14174"
                     /db_xref="CDD:271076"
     misc_feature    order(190..204,214..216,253..255,259..261,349..351,
                     397..408,418..420,424..426,532..537,541..543,547..552,
                     556..558,595..600,607..609,673..687,691..693)
                     /gene="Mknk1"
                     /note="active site"
                     /db_xref="CDD:271076"
     misc_feature    order(190..204,214..216,253..255,259..261,349..351,
                     397..408,418..420,424..426,532..537,541..543,547..552,
                     556..558,595..600,607..609,673..687,691..693)
                     /gene="Mknk1"
                     /note="active site"
                     /db_xref="CDD:271076"
     misc_feature    order(190..201,214..216,253..255,259..261,349..351,
                     397..408,418..420,547..552,556..558,595..600)
                     /gene="Mknk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(190..201,214..216,253..255,259..261,349..351,
                     397..408,418..420,547..552,556..558,595..600)
                     /gene="Mknk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(202..204,418..420,424..426,532..537,541..543,
                     547..549,607..609,673..687,691..693)
                     /gene="Mknk1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(202..204,418..420,424..426,532..537,541..543,
                     547..549,607..609,673..687,691..693)
                     /gene="Mknk1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    565..567
                     /gene="Mknk1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    580..582
                     /gene="Mknk1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    595..687
                     /gene="Mknk1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271076"
     misc_feature    595..687
                     /gene="Mknk1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271076"
     misc_feature    652..654
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    667..669
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    order(817..819,829..831,853..855,862..864)
                     /gene="Mknk1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(817..819,829..831,853..855,862..864)
                     /gene="Mknk1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    1057..1059
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     exon            164..261
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..341
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..415
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..520
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..576
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..672
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..867
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1032
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1076
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1927
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctcgact gagacctgca ggtgggggtg cgcgcggccg ttcccgcggt ggtcaactaa
       61 gagatgggca gcagtgagcc ccttcccatc gtggatagtg acaagaggag aaagaagaag
      121 cgtaagaccc gggccaccga ctctctgcca gggaagtttg aagacgtgta ccagctgacc
      181 tcagaattgc tgggagaagg agcctatgcc aaagtccagg gtgccgtgag cctgcagagt
      241 ggcaaagagt atgcagtcaa aatcatcgag aagcaagcag gacacagtcg aagccgagta
      301 ttccgtgagg tggagacgtt gtaccagtgt caaggaaaca ggaacatttt ggagctgatt
      361 gaattctttg aagatgacac acgattttac ttggtctttg agaaattgca aggaggctcc
      421 atcctagcac acatccagaa gcggaagcac ttcaatgagc tagaagccag cagagtggtg
      481 cgggatgtcg ccactgccct tgatttcctg catactaaag gcattgctca ccgtgatctg
      541 aagccagaaa acatattgtg cgaatctcca gaaaaggtgt ctccggtgaa aatttgtgac
      601 tttgacttgg gcagtggagt aaaattgaac aactcctgca ctcccataac cacaccagag
      661 ctgaccactc catgcggctc tgcagagtat atggcacctg aggtggtgga ggtctttagg
      721 gacgaggcta ctttctatga caagcgctgt gacctgtgga gcctgggtgt ggtcctctac
      781 atcatgctga gtggctaccc cccctttgta ggtcactgtg gggctgactg cggctgggac
      841 cggggagagg tatgcaggat gtgccagaac aagctgttcg aaagcatcca ggaaggcaaa
      901 tacgagtttc ccgacaaaga ctgggctcac atctccaccg aggccaaaga cctcatctct
      961 aagctcctgg ttcgagatgc gaagcagaga ctcagcgctg cccaagttct gcagcatcca
     1021 tgggtgcaag ggcaagctcc agaaagggga ctccccacgc cgcaagtcct tcagagaaac
     1081 agcagcacca tggacttgac actcttcgca gctgaggcca ttgccctcaa ccgccagctg
     1141 tctcagcatg aagagaatga actggctgag gaacacgagg ccctagccga gggcctctgc
     1201 tccatgaagc tgtcccctcc atccaaatct cgcctggcac gaaggcgagc cctggcccac
     1261 gctggccgag aagcaaactc ttgttccaca cccgcagggc tctgaactga tatgcaggca
     1321 caccttgtcg gtgccccctg acaacctacg aggtcaaagt gtgaagctag ccgagggacc
     1381 tgccctgcag ccccagcagg cctttaccat ccacaaaggc tcctgggttc ccacccatcc
     1441 cccatttccc ttgggtcctc aaaggaaaaa gctttttcca aaggggttgt ctttgaaaag
     1501 gaaggcaatc acttgtcact ttgcataata gcctgcagca ggaacatctc tctgcccggc
     1561 tccaactgct cccagtgtgc agatcccgga tccagctttt ggtgggggct gctggggctg
     1621 cagccttcag ggagccggct tccaggagct gacagaagct gacagacacg cctcttctcc
     1681 cctgcactgt caccttctcc caccttcctc tgtcctacag acgtcctctc tgcctgtctt
     1741 ctccccggct gagcaaagcc atcccctcaa ttcaggaagg gcagggaacc aaccagatca
     1801 gtcttccagt ctgtagcacg gagaagcaca taatctttct ttgccttgac cgagatgtct
     1861 tcctcattta tcatcctctt ccgtgtttcg gattgttgct aaagtcagta ttattccttt
     1921 ttaaaaa
//
LOCUS       NM_001438116            2899 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 4, mRNA.
ACCESSION   NM_001438116 XM_039082047
VERSION     NM_001438116.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2899)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039082047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.358185.1,
                                           SRR21887620.1432869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-856             JAXUCZ010000001.1  96116217-96116393   c
            857-922             JAXUCZ010000001.1  96115848-96115913   c
            923-1105            JAXUCZ010000001.1  96111458-96111640   c
            1106-1274           JAXUCZ010000001.1  96111181-96111349   c
            1275-1506           JAXUCZ010000001.1  96109086-96109317   c
            1507-2899           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2899
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1530
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 4 is encoded by transcript variant 4; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 4"
                     /protein_id="NP_001425045.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKDKLEKQEKPVNGE
                     DKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNA
                     ETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFA
                     DFEYRKDNKVAA"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    1009..1338
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    1009..1338
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            857..922
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1105
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1274
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1506
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2899
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagg tcgatcaagc cctcagttag accctttgag aaaaagtcca
      721 accatggaac aagcagtgca gaccgcctcg gcccacttac ctgctccagc acctgttggg
      781 agaaggagcc ctgtacccgc caggcctttg ccacctacca gccagaaagc aatagacaac
      841 caagagcaca ggcgagctga agttcacaaa gtcccaaggc cagaaaatga gcaactcaga
      901 aatgacagca agaggcaagt agttcctgga gttccttctg ctccaagaag aggacgtggg
      961 ggtcatcgag gtggcagggg aagatttggt attcgtcgag atggtccaat gaaatttgag
     1021 aaagactttg actttgaaag tgcaaatgca caatttaaca aggaggaaat cgacagagag
     1081 tttcataata aacttaaatt aaaagataaa cttgagaaac aagagaaacc tgtaaacggt
     1141 gaagacaaag gagactcggg agttgatacc cagaacagcg aggggaatgc tgatgaggaa
     1201 gatccccttg ggcccaactg ctactacgac aaaaccaaat ccttcttcga caacatctct
     1261 tgtgatgata atagagaaag gagaccaact tgggctgaag aaagaaggtt aaatgctgaa
     1321 acttttggaa tcccacttcg tccaaatcgt ggccgtgggg gttaccgagg cagaggaggc
     1381 cttggcttcc gtggtggcag aggacgtggt agtggccgag gaggaacctt cactgcccct
     1441 cgagggtttc gtgctggatt cagaggcgct cgtgggggta gggagtttgc agattttgaa
     1501 tataggaaag acaacaaagt tgctgcatag tctacaaaca agtctctgaa cataggtgac
     1561 tcctagctct tcatggtcct ggaaagtggt tcggtctttg tgaagaatga agaagtgaag
     1621 ttgctgtctg tctgtcacca gcactgggtt ttgtctgttt tctgcttcac gtcaaagcta
     1681 tactgcagtt gctttggggc aggaaggctc gtcttaaaac acaagcataa gtgtgtgtgg
     1741 agtagcaggt tatgattcct tgcttagagt tgaactaaag ccagctaaat ggaattgcta
     1801 agtgtttttt cttcaatgaa aggatttttc ttatcactaa ttaattgtat tcggcaatta
     1861 ctttgagttg cctgcagata ggccgtgata ctgtgttttg agccacagaa agttttgtgt
     1921 gtgtgcgcgc gcgcgcgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtacgt gtgtgtccca
     1981 taatatgagg tagcttattt cgacacttaa ttagggtgct ggatggtaga gaattttgtc
     2041 agtcaactat gtacacacag gtaaatactg tttcttaggc aaaggtaact tttttatata
     2101 gttgtaaaat tccattatat tccattgcca aagaaacatt aagaactttg tatagctgta
     2161 taaaaagcaa ctaatttttt aaagaataaa cgttttaaag tcagcaaaca tacgtgtcct
     2221 tgcagaagtc agtgtgctga ggagcaggga tatgggtggg tctttttccc cttgctttcc
     2281 aggcttaagg ttttttattt cctttgtaat gtttggaaca caaatgaaga tttgataact
     2341 ttattccatt atctaaaaag cataaattat tcatgcatag tgtatggact tcgttttgta
     2401 gcaaatcaca ggatttgttc aaataacaga tattttaagt gtgtgaatgt aaataatcat
     2461 agatgagaat gtaccttgct gtattttcaa ataagtaacc ttctcctttt taagacatta
     2521 agactcgttg atctatcagt tgacccgctc ctcctgctat gcctggaatt ctgttgtggt
     2581 aatgctgact cctgttttcc atcaaaaaga tggagttttc agaatcatct ggcacctgta
     2641 aaacatcact aacatagtgt gtaggcctgc ggcctaccga tgactctgta cacgtttgtt
     2701 gctaactgta aattactaat aaatcttttt tgatatttaa gctatagtgg aaaaagatct
     2761 ggccactttg tgtttttaat aaaggccatg gaataaaggg atccaaagat ttcaatattt
     2821 ttaactatat tggcttttgt taactttctc aataaaacat tgagtagtga tagacgtgtg
     2881 ggaaactgca ctgtaggag
//
LOCUS       NM_001107592            5554 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus lysyl oxidase-like 4 (Loxl4), transcript variant
            2, mRNA.
ACCESSION   NM_001107592 XM_001055686 XM_239059
VERSION     NM_001107592.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5554)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   2  (bases 1 to 5554)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 5554)
  AUTHORS   Ito,H., Akiyama,H., Iguchi,H., Iyama,K., Miyamoto,M., Ohsawa,K. and
            Nakamura,T.
  TITLE     Molecular cloning and biological activity of a novel lysyl
            oxidase-related gene expressed in cartilage
  JOURNAL   J Biol Chem 276 (26), 24023-24029 (2001)
   PUBMED   11292829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001107592.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.7287.1,
                                           SRR26643287.3889.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000001.1  251365488-251365542 c
            56-351              JAXUCZ010000001.1  251361283-251361578 c
            352-530             JAXUCZ010000001.1  251360597-251360775 c
            531-736             JAXUCZ010000001.1  251359692-251359897 c
            737-775             JAXUCZ010000001.1  251358181-251358219 c
            776-995             JAXUCZ010000001.1  251357820-251358039 c
            996-1182            JAXUCZ010000001.1  251357101-251357287 c
            1183-1337           JAXUCZ010000001.1  251356797-251356951 c
            1338-1505           JAXUCZ010000001.1  251356103-251356270 c
            1506-1668           JAXUCZ010000001.1  251355119-251355281 c
            1669-1912           JAXUCZ010000001.1  251352776-251353019 c
            1913-2028           JAXUCZ010000001.1  251351618-251351733 c
            2029-2165           JAXUCZ010000001.1  251350874-251351010 c
            2166-2277           JAXUCZ010000001.1  251350430-251350541 c
            2278-5554           JAXUCZ010000001.1  251345438-251348714 c
FEATURES             Location/Qualifiers
     source          1..5554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5554
                     /gene="Loxl4"
                     /note="lysyl oxidase-like 4"
                     /db_xref="GeneID:309380"
                     /db_xref="RGD:1308588"
     exon            1..55
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    3..5
                     /gene="Loxl4"
                     /note="upstream in-frame stop codon"
     exon            56..351
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2348
                     /gene="Loxl4"
                     /EC_number="1.4.3.13"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lysyl oxidase homolog 4"
                     /codon_start=1
                     /product="lysyl oxidase homolog 4 isoform 2 precursor"
                     /protein_id="NP_001101062.1"
                     /db_xref="GeneID:309380"
                     /db_xref="RGD:1308588"
                     /translation="MMWPPPPTFSVFLLLLLSQVPSSRPQSPGTKKLRLVGPANRPEE
                     GRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKFGQGEGPIWLDNVR
                     CLGTEDTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQQGYHSEKVSNALGPQGRRLEEV
                     RLKPILASAKRHSPVTEGAVEVRYEGHWRQVCDQGWTMNNSRVVCGMLGFPSQAPVNS
                     HYYRKVWNLKMKDPKSRLNGLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPA
                     CPGGMHAVVNCVAGPHFQRQKPKPKRKESGAEQELKVRLRSGAQVGEGRVEVLMNRQW
                     GTVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYEQTIGDC
                     LALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGT
                     VCSDHWGLTEAMVTCRQLGLGFANFAIKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQ
                     CQRHGPVHCSHGSGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENC
                     LSKSADHMDWPYGHRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTH
                     YDLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDC
                     QWVDITDVSPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDPYR
                     PNAELSLEQEQRLRNNLI"
     sig_peptide     72..146
                     /gene="Loxl4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    168..470
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    168..470
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    600..932
                     /gene="Loxl4"
                     /note="Scavenger receptor cysteine-rich domain; Region:
                     SRCR; pfam00530"
                     /db_xref="CDD:459844"
     misc_feature    600..932
                     /gene="Loxl4"
                     /note="Scavenger receptor cysteine-rich domain; Region:
                     SRCR; pfam00530"
                     /db_xref="CDD:459844"
     misc_feature    1008..1310
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1008..1310
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1410..1661
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1410..1661
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1674..2270
                     /gene="Loxl4"
                     /note="Lysyl oxidase; Region: Lysyl_oxidase; pfam01186"
                     /db_xref="CDD:460102"
     misc_feature    1674..2270
                     /gene="Loxl4"
                     /note="Lysyl oxidase; Region: Lysyl_oxidase; pfam01186"
                     /db_xref="CDD:460102"
     exon            352..530
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            531..736
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..775
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            776..995
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1182
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1337
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1505
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1668
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1912
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2028
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2165
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2277
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..5554
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttagcgctg ctcagccccg gcgcccggcc cagccccgac ctctggatcc agccggtgcc
       61 ccgaagtcac catgatgtgg cccccaccac ccaccttctc cgtgttcctg ctactgctgc
      121 taagccaagt cccctccagc aggccacagt caccaggcac caagaagctc aggcttgtgg
      181 gcccagcgaa caggccagag gagggccggc tggaggtgct gcaccagggc cagtggggta
      241 cagtgtgtga tgatgacttt gctctccagg aggctacagt ggcctgccga caactgggct
      301 ttgagtcagc cttgacctgg gcacacagtg ccaagtttgg ccaaggagag ggccccatct
      361 ggctggacaa tgtccgttgt ttgggcaccg aggacaccct agatcagtgt ggctctaacg
      421 gctggggtgt cagtgactgc agacactcag aagacgttgg ggtggtgtgc catccacggc
      481 gccagcaggg gtatcactct gagaaggtct ccaatgccct cgggccccag ggccggcggc
      541 tagaagaggt gcggctcaaa cccatcctcg ccagtgccaa aaggcacagc ccagtaactg
      601 agggggctgt ggaagtacgg tacgagggcc actggaggca ggtgtgtgac cagggctgga
      661 ccatgaacaa cagcagggtt gtgtgcggga tgctgggctt tcccagtcag gcacctgtca
      721 acagccacta ctacagaaaa gtctggaatc tgaagatgaa ggatcccaag tctagactca
      781 atggcctgac aaagaagaac tccttctgga ttcaccgggt tgactgtttg gggacagaac
      841 cccacttggc caagtgccag gtacaggtgg ctccaggaag aggcaagctc cggccagcct
      901 gtccgggcgg catgcacgct gtggtcaact gtgtggcagg gccgcatttt cagcgacaga
      961 agccaaagcc taagcgcaag gagtctggcg cagagcagga gctgaaagtg cgcctgcgct
     1021 ctggggctca ggtgggtgag ggccgtgtgg aagtgctcat gaaccgccag tggggcacag
     1081 tctgtgacca caggtggaac ctcatctcag ccagcgttgt gtgtcgccag cttggctttg
     1141 gctctgcccg ggaggccctt tttggggccc agttgggcca agggctaggg cccatccacc
     1201 tgagtgaagt gcgctgcagg ggctatgagc agaccatcgg cgactgcctt gccctagaag
     1261 ggtcccagaa tggttgtcaa catgcaaatg acgctgctgt caggtgcaac atccctgaca
     1321 tgggcttcca gaacaaggtg cgcttggctg gtgggcgcaa ctcggaagag ggcgtggtgg
     1381 aggtgcaggt ggaggtgaat ggggtcccac gctgggggac tgtatgcagt gaccactggg
     1441 ggctcactga agccatggtg acctgtcggc aactcggtct gggatttgcc aactttgcta
     1501 tcaaggacac ctggtactgg caggggacac cagaggccaa agaagtggtg atgagtggag
     1561 ttcgctgctc aggcacagaa atggcccttc agcagtgtca gaggcatggg cctgtgcact
     1621 gctcccacgg ctcggggcgc ttctcggccg gcgttgcctg catgaacagt gctccagacc
     1681 tcgtgatgaa tgcccagctg gtacaagaaa cggcctactt ggaggatcgt ccactcagca
     1741 tgctgtactg cgctcatgag gaaaactgtc tctccaagtc cgctgaccac atggactggc
     1801 cgtacggaca ccggcgcttg ctgcgcttct cctcacagat ctacaacctt ggccgggctg
     1861 acttccgtcc caaggctgga cgacacagct ggatttggca ccagtgccac aggcactacc
     1921 acagcatcga ggtcttcacc cattatgacc tgctcacact caatggttcc aaagtggctg
     1981 aggggcacaa ggccagcttc tgtctagaag atacaaactg cccctcagga gtgcagcggc
     2041 gctatgcgtg tgctaacttt ggggaacagg gagtggctgt aggctgctgg gacacctacc
     2101 ggcacgacat cgattgccag tgggtggata tcacagatgt gagtccaggg gactatatct
     2161 tccaggtggt tgtgaacccc acaaatgatg tggcagaatc agacttctcc aacaacatga
     2221 ttcgatgccg ctgcaagtat gacgggcagc gagtctggct gcacaactgc cacacaggag
     2281 atccctaccg acccaatgca gagctctccc tggagcagga acagcgactc aggaacaact
     2341 tgatctaaag ccgttattgc acgcccccag ctccgctcac acaccagata cctcagctta
     2401 ctggagccat gcccttcaca aagccctgac tcacaggaca aggggccagt gacaaggagc
     2461 accaagaagc tgctcaggaa gcctttcagt ggccagatca tcaccgggat ggcagtactc
     2521 tcaggacggc tctggcccct ccagagcact tatggcctag atagcatggc cttgaggctc
     2581 tgaccagcta aaccttctct tccttaagga gactcgacct ttcttacaac ttgatgcaca
     2641 gttcccagct tcaggagctc caagttcctc agggatgaac tgtgaccaag gtcctccctc
     2701 tctaagtggt gcttcacaag tgtcttggag gaacacagga cagaggagca gagaacacaa
     2761 gaagtggatg gagtcagtcc tctctgctat gtgctccatg caaaataacc atgtcaaagt
     2821 cacacctggc agagaggctg gtgaatgcag tccctctgct tatcctccct cagaggctct
     2881 gaagcctctc cttggcagtt ttaccacaca cacacacaca cacacacaca cgtacatttc
     2941 taatacccct gaaccctcaa gcctcctgat ggatcaacat cctgattact ggggctgggg
     3001 gtggtggtgg caagttaccc agaatggcaa gacagggcct ttcctgaaga gtagcaagaa
     3061 atcaagaaga cagctgaggt cacaagttca gcctttgagg acctctgcca agggagacaa
     3121 caggaagccc atatctggca ggcagtccag tctcttagaa tcacctacat tgcaaggtta
     3181 gcctaaattt cagatttaac caaggccact tcaccttaac aaactgagaa gaactgcgat
     3241 agagaagttg gtcagtacag cccctctgca ggaacgccaa aacaggtctg gtagagttag
     3301 gaacacaaga ctgagtcaac aagaagcaag aacgcttaat ttagttcagg actgaacctg
     3361 ggaaaagcca ccatccacag agaggtggct gtgctctgct tttgctcaac tggtataaga
     3421 tctgaagtct ttctgggcat gcctggacct tttatccatg gacgtacaca cggatgtctt
     3481 ctaggtctta taatccaata aaggctgctc attatgggct gctacagaga ccagagcagc
     3541 tgtacttccg tagctcccag tgcattgcac tctgccctct tccctccaga gctggatgat
     3601 acgcagaaca cattccttgg tacagcccac cctaacctgc ttccctgtta cgctgcccga
     3661 ggtcaacagt gatcctcggg tctggaaggc gagaagtgaa agggaagaat gagaaggtgc
     3721 aacccaaaga ctgtaaactt ttataataga ggctacaaaa tcaaaataaa tggtaggaga
     3781 cagaactgat ttacagtatt ctccgcccca cattacaaga gctactctga cagtcaagag
     3841 acatgttttg gggtgccttc cgtgaactaa aagtgccttt tccgtctcct ccgtcccgtc
     3901 atccccttca tctggcacag gaagcctatt ctggtgtaac ggtttaggta aacaagggaa
     3961 ggactgattt cctgttggat ccagcgaaca gtgacatact cacacatgaa gctaatggtc
     4021 tgcaaaagaa tgtgcagcta gctagggtgg ggtggggtgg ggtggtgagt gatgatagac
     4081 ctgggcaggg aggttaccct caccttcttg ttggatctag tttccaagag gccagaaaaa
     4141 gcaggccagg cagacagcca ccagcactgg tctcagcttt ctggcccaca tcacacgact
     4201 ggtaggtgca gccaattcta attcctggaa aaagctatac aagggctgcg ctgttagacc
     4261 tctgagttga aagggaaaga cacgggaagg ttggtggctg gcatgactta tataacgaga
     4321 tgaggaatgt taacagaata ccaaccgcca aattccaggc agaaccaaaa cctcagaaga
     4381 ctttcacctt ggcaccctga gtgcttcaga gaagggttag gaagctctcc tcagaagcta
     4441 ggctaatgct accaagactt tcacgctgtg aggagagaac tagaatccac aggaactgtg
     4501 actttctact acagatttga cgtaaccctg agatttagat gtttaccata tacaagacac
     4561 ttagtagacg ggagtacctg acatgccgtc ccccatagct aacatttctc tcacagcagc
     4621 caccctgctc tccttatttt agagaggtct gttctatggg acagtagcag ccacacggtg
     4681 ctctcccatt aactcctttt ataaaagttc ggtttagata taaccaagga tttgatgcta
     4741 tatggacaag ctgggcccat ggctgggact tcgtatcact gaccagtaca cagtatcccc
     4801 agctactgga ataatttaag caaaaagcac atttccaatt ggaagtaaaa cggcaatgct
     4861 tcataacttt caaatgttga cttaaaaaaa ttgttctctg agcctgacta gagttatcct
     4921 gagtaatagt agtagctgat taccagatag ctaggttgct agaacactac tgtcagaata
     4981 aaaaagaatt tgttttagaa atgagacttt tttaaaaact gggtaataaa cattaacagt
     5041 gcctttagaa gaagggcatg aagcagttaa caagaagtcc tttcacaggc aggtgacaag
     5101 agctgctgct ttttttcttt ttcttttctc atcctcaagg tcactccgga cattgagaag
     5161 tccagcctgg gaatgtagct cagaggtgaa tgctgtctaa cacatgtgtg gtcacggtca
     5221 tggtcttggg gtagggtgtg aaaacatggc aggtgtgtgc cttcaaagtg tctctcagta
     5281 taaagccatg ctggggctgg agcaatggct tcttccagag gacccaggta caattcccag
     5341 cgcccatgtg gtgacccata accagctgta attccagtcc caggagatct aacacacact
     5401 tctggcctct acagttacca ggaattcaga cgtacataaa attaataata acagaaaagt
     5461 aataaagtaa catgtaatat aaaataaata tatttatact atattattat attaataata
     5521 aacaacataa aaattaataa aagccaatac taga
//
LOCUS       NM_001438061            6502 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 2, mRNA.
ACCESSION   NM_001438061 XM_063264948
VERSION     NM_001438061.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6502)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6502)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6502)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6502)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6502)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6502)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6502)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6502)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6502)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6502)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063264948.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.9063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-997             JAXUCZ010000001.1  255057982-255058080
            998-1145            JAXUCZ010000001.1  255060666-255060813
            1146-1369           JAXUCZ010000001.1  255061098-255061321
            1370-1535           JAXUCZ010000001.1  255062208-255062373
            1536-1747           JAXUCZ010000001.1  255063221-255063432
            1748-1846           JAXUCZ010000001.1  255063987-255064085
            1847-2041           JAXUCZ010000001.1  255069136-255069330
            2042-2231           JAXUCZ010000001.1  255069541-255069730
            2232-2372           JAXUCZ010000001.1  255069954-255070094
            2373-2461           JAXUCZ010000001.1  255070390-255070478
            2462-2664           JAXUCZ010000001.1  255071464-255071666
            2665-2788           JAXUCZ010000001.1  255072193-255072316
            2789-2914           JAXUCZ010000001.1  255072589-255072714
            2915-2997           JAXUCZ010000001.1  255072981-255073063
            2998-3234           JAXUCZ010000001.1  255073935-255074171
            3235-3328           JAXUCZ010000001.1  255074448-255074541
            3329-3505           JAXUCZ010000001.1  255074797-255074973
            3506-3570           JAXUCZ010000001.1  255075722-255075786
            3571-3694           JAXUCZ010000001.1  255075873-255075996
            3695-3766           JAXUCZ010000001.1  255076149-255076220
            3767-3861           JAXUCZ010000001.1  255076331-255076425
            3862-4015           JAXUCZ010000001.1  255076801-255076954
            4016-4241           JAXUCZ010000001.1  255081461-255081686
            4242-4402           JAXUCZ010000001.1  255082250-255082410
            4403-4649           JAXUCZ010000001.1  255082513-255082759
            4650-4843           JAXUCZ010000001.1  255082874-255083067
            4844-4994           JAXUCZ010000001.1  255085207-255085357
            4995-5125           JAXUCZ010000001.1  255085463-255085593
            5126-5227           JAXUCZ010000001.1  255085758-255085859
            5228-5341           JAXUCZ010000001.1  255086114-255086227
            5342-5522           JAXUCZ010000001.1  255086358-255086538
            5523-5651           JAXUCZ010000001.1  255086830-255086958
            5652-6502           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6502
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5932
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 2 is encoded by transcript variant 2;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 2"
                     /protein_id="NP_001424990.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKISPCL
                     LNTLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKRSPRPPRHTTKV
                     MPGSELPTPNGAALSSNLTGGMPFIEAPTSISSASSEAASTVVSPCTDSGLELSSQAT
                     SKEDLTDLEQAGSPREITTTEPGSTEIGVSDQLDPQEGAHVEKAQSASVESIPEVLEE
                     CTSPTDHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNP
                     HDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSVERLNLYAA
                     SLRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPS
                     FVTELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAH
                     CQAKVLNTLNQQEKKETARPGFEAVDGSPDTYKSERAASDGKATGVPSDAPGLHFSSG
                     GWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPPRFSCLLPDPRELIEIKNKKKLLITGT
                     EQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNMDLLE
                     SFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNGSPFANSDAC
                     FALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKN
                     EEIVMPEEQTGLVRENYVWSVLLHRGATPEGIFLRVPPGSYDLDLFTMTWGPTIAALS
                     YVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPS
                     VFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVD
                     PNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQ
                     CDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRV
                     GCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILLL
                     MKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATA
                     RADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKMHRSATDADMANSG
                     WLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLTVGLDLGPHDTKSLLKCVESLSFIVR
                     DAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRGKSHKYDSKGNRFKKKPKEGSML
                     RRPRASSQHATRAGHSDEEEDEGVPASYHTVSLQLLDLMHTLHTRAASIYSSWAEEQR
                     HLETGGRKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQK
                     LDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSL
                     STFAALWLTILDFMDKYMHAGSSDLLSEAVPESLKNMLLVMDTAEIFHSADARGGSPS
                     ALWEITWERIDCFLPHLRDELFKQTVIQDPMPTEPHSQKPLASTHLTPAAGDPRMPGH
                     PPPPEIPSEVGACDPEKPESTRAASSSSPGSPVASSPSKQSPAPEGPPPLAQPPLILQ
                     PLTSPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN"
     misc_feature    <1643..>3892
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1643..>3892
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2453..3010
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2453..3010
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5531..5923
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5531..5923
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..997
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1145
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1369
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1535
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1747
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1846
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2041
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2231
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2372
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2461
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2664
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2788
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..2997
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3234
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3328
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3505
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3570
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3694
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3766
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3861
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..4015
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4241
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4402
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4649
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..4994
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5125
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5126..5227
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5228..5341
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5342..5522
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5651
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5652..6502
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagat
      901 ttctccatgt ctcctcaaca cactggagct aagtagtggg gagcagacca aagccctgaa
      961 ccagttagag agggtactac tctttaagaa cctcaagctg aaaatgagag caggaggcat
     1021 gagtgactca tccaagtgga agaaacagaa gcgatcccct cgacctccac gtcatacaac
     1081 caaagtcatg ccaggttcag agctgcccac cccaaatgga gccgccttat cctctaacct
     1141 tactggtggc atgcccttca ttgaggcacc cacatccatc tcctctgcaa gttcagaagc
     1201 tgcctccaca gtggtcagtc cctgtacaga tagtggcctg gaattatcct cccaggctac
     1261 ctccaaggag gacctcaccg acctggagca agctggctcc ccaagggaga tcaccaccac
     1321 agagcctggg agcactgaga taggagtttc tgatcagctt gaccctcagg aaggggccca
     1381 tgtagaaaag gcccagtcag catcggtgga atctatccct gaagtgctag aggagtgcac
     1441 atcccctact gaccattctg actctgcctc tgtccatgac atggattatg tcaatcctcg
     1501 gggcgtgcgc tttacccagt cctcccagaa agaaggcaca gctttggttc cttatggtct
     1561 tccttgcatc cgtgagctct tccgcttcct tatctccctc acaaatccac atgaccgcca
     1621 taactctgag gttatgatcc acatgggact tcatttgctg acagtagctc ttgagtcagc
     1681 ccctgtggcc cagtgccaga ccctcttggg tctcatcaag gatgagatgt gccgacactt
     1741 attccagcta ctcagcgtag agcggctgaa cctttacgct gcttccctac gagtgtgctt
     1801 tttgctcttt gagagcatgc gggaacacct caagttccag ttggagatgt acatcaaaaa
     1861 gctcatggag attatcactg ttgaaaaccc caagatgcct tatgagatga aggagatggc
     1921 gctggaggcc attgtgcagc tctggcgcat ccccagcttc gtcacggagc tctacatcaa
     1981 ctatgactgt gactactact gctccaacct cttcgaagac ctcactaagc tgctgtccaa
     2041 gaatgccttt cctgtgtctg gccagcttta tacaacacac ctgctgtctc ttgatgccct
     2101 attgacagtt attgacagca ctgaggctca ttgtcaggcc aaagtcctca acaccctcaa
     2161 ccagcaagag aagaaagaga cagccagacc tggctttgag gcagtggatg gcagcccaga
     2221 cacttacaag tctgagagag cagccagtga tgggaaagcc acaggagtgc cctcagatgc
     2281 tccaggcctt catttttcaa gtggagggtg gttgtcaaca gaacatggaa agccagggtg
     2341 cagtgatctg gaggaagctg gtgactctgg ggttgacaaa aagaccacca ggaagccacc
     2401 tcgattttcc tgtcttctgc cagatccacg ggaactaatt gaaattaaaa acaaaaaaaa
     2461 gctgctgatc actggtacag agcagttcaa ccaaaaacca aagaagggga tccagtttct
     2521 gcaggagaaa ggcctcctca ccatcccaat ggataacaca gaggtagccc agtggctccg
     2581 agaaaaccct cggctagaca aaaaaatgat tggagagttt gtgagtgacc gcaaaaacat
     2641 ggacctgttg gagagttttg tgagcacctt cagcttccag ggtctgaggc ttgatgaggc
     2701 tctccgcctc tacctagaag ccttccgtct gcctggggaa gcgcctgtta ttcacaggct
     2761 gctggaggtg ttcactgagc actggaggag ttgtaatggc tccccatttg ctaatagcga
     2821 tgcctgcttt gccctggcct atgctgttat catgcttaac actgaccaac ataaccacaa
     2881 tgttcgcaag caaaatgcac ccatgaccct ggaggagttc cgcaaaaacc tgaaaggtgt
     2941 gaatggaggc aaggactttg agcaagacat cctggaagac atgtaccatg ccatcaagaa
     3001 tgaggaaatt gtgatgcctg aggaacaaac aggtctggtt cgtgagaatt atgtgtggag
     3061 tgtgctgctt catcgaggtg ctacccctga gggcatcttc cttcgtgtac cccctggcag
     3121 ctatgatctt gacctcttca ctatgacctg gggccccact attgctgctc tctcttatgt
     3181 gttcgataaa agcctcgagg agaccatcat ccagaaagcc atctcaggct tcaggaagtg
     3241 tgccatgatc tccgcccact atggcctcag cgatgtgttt gacaatctca tcatctctct
     3301 gtgcaaattc acagctctaa gtagtgagtc tattgagaac ctgcccagtg tattcggaag
     3361 caaccctaaa gcccacattg cagccaagac agtattccat ttggcccatc gtcatggtga
     3421 catccttcgg gagggctgga agaatatcat ggaggccatg ctgcagctct tccgagccca
     3481 acttttaccg aaggctatgg tagaggtaga agattttgtg gatcccaatg gtaagatctc
     3541 tctacagcgg gaggagacac catcaaaccg aggagagtca acagtcctta gttttgtaag
     3601 ctggctgaca ctgagtggtc ctgagcagtc cagtgtccgg ggcccatcga cagagaacca
     3661 agaggccaag cgagtagcct tggactgcat caagcaatgt gacccagaaa agatgatcac
     3721 agaaagcaag ttcctccagc tggaatctct gcaggagctc atgaaggctc tggtctcggt
     3781 gacaccagat gaagagacat atgatgaaga agatgctgct ttctgtctgg agatgctgct
     3841 aaggattgtg ttagaaaaca gggaccgtgt gggctgtgta tggcagactg ttcgagatca
     3901 tctataccac ctgtgtgttc aggcacaaga tttctgcttc cttgtggagc gagcagtggt
     3961 agggctgcta cgcctagcca ttcggctact ccgaagagaa gagattagtg gccaggtcct
     4021 gctctctctg cgcatcttgt tactgatgaa gcccagcgtg ctgtccagag tcagccacca
     4081 ggtcgcttat gggctgcatg aactcctcaa gaccaatgct gccaacatcc actcgggtga
     4141 tgactgggcc actctcttca cattgctgga gtgcattggc tcaggcgtga agcctccaga
     4201 tgctctacaa gccacagcca gggctgatgc tcctgatgct ggagcacaat ccgacagtga
     4261 gctcccatcc taccatcaaa atgatgtcag cctagaccga gggtacactt ccgactcaga
     4321 agtctacact gaccatggca ggcctggcaa gatgcaccga tcagccacag acgctgacat
     4381 ggccaacagt ggttggttag tggtggggaa ggatgacatt gataactcca aaccagcagc
     4441 aggactcagc aggccaggcc cttcgccctt ggtcaatcag tacagcctta cagtgggcct
     4501 ggacctggga ccacatgaca ctaagtcctt gcttaagtgt gtggagtctc tgtccttcat
     4561 tgttcgtgat gctgctcaca tcacccctga caactttgaa ctctgcgtca agaccctccg
     4621 catctttgta gaagccagtc tgaatggtgg gtgcaagtcc caggataaac gtggcaagag
     4681 tcataaatat gacagcaaag ggaaccggtt caagaaaaag cccaaggagg gctcgatgct
     4741 tcggcggccc cgggcatcca gccagcatgc cactcgggct ggacacagtg atgaagagga
     4801 ggacgaaggc gtgcctgcca gctaccatac ggtgtcttta cagttgctag acctgatgca
     4861 caccctgcac acacgggcag cctctatcta cagttcatgg gcagaggagc aacgccacct
     4921 ggagacaggt ggccggaaga ttgaagctga ctcacgtacc ctctgggccc actgctggtg
     4981 ccctttatta caaggtatcg cttgcttatg ctgtgacgcc cggcgccagg tgcggatgca
     5041 ggccctgaca tatctccagc gagcccttct ggtacatgac ctgcaaaagc tagatgccct
     5101 ggaatgggag tcctgtttta acaaggtgct gtttccgcta ctgaccaagc ttttagaaaa
     5161 tatcagccct gcggatgtgg gcgggatgga ggagacccgg atgcgggctt ccacactgct
     5221 ctcaaaggtc ttcctgcagc acctgtcccc actgctgtcc ctgtccacct ttgctgccct
     5281 gtggctcacc atcctggact tcatggacaa gtacatgcac gcaggttcca gtgacttgct
     5341 gtcagaagct gtccctgagt ctctgaagaa catgctcctt gtgatggaca cagcagagat
     5401 tttccacagt gcagatgcaa ggggaggcag cccctctgct ctctgggaga tcacctggga
     5461 gcgcatcgat tgcttcttac cacacctacg tgatgaactc ttcaagcaga ctgtcatcca
     5521 ggaccccatg cccacagagc ctcacagtca aaaacctctg gcttctactc acctgacgcc
     5581 tgctgctggt gaccccagga tgcctggcca tccacctcct ccagagatac cctcagaagt
     5641 gggagcttgt gacccggaga agcccgagag caccagagct gccagcagca gctcccctgg
     5701 atcgccggtg gcctctagcc ccagcaaaca gagtcctgcc ccagagggac ctcccccact
     5761 ggcccagccc ccactaatcc tacagccctt gacctcccca ctgcaggtgg gggtaccacc
     5821 catgactttg cccatcatcc tcaaccctgc actcattgag gccacctctc cagtgcctct
     5881 cttagccacg ccacgcccta cagaccccat ccccacctct gaggtcaact aaggcagcca
     5941 ctcagaggtc aggaccattc cttcctatca ggcattcaag gccctgcttc cagtcccagg
     6001 ggccacagaa atcttcaggc ccaaagcaag ctgctgttac cactgcttga cagggggatg
     6061 acgatgttta tagtccctgc tgggatccac tccaggctgc gaggttcttc ctctgccgtt
     6121 cagtcctgaa cttccaagct gagagtggat gcaggctgaa cctgtagcct ctgcctctgg
     6181 cctggcagcc ctggggaggc atagagccaa ccctgctgtg ccaaccctgc agtgcctgcc
     6241 atgtgccccc tgccaggttg ggcattagga gccaagcccg acctctctgc actttgttcc
     6301 tctccctatc cagtccatca gtcctgggcc actgcctcca gttcttcttc cttcattaaa
     6361 tagttggtca gtttggagtc gcttggcacc atggagggtg gacaggtagg actcgatggg
     6421 gggtctgccc acaggagcat gtacatatgg aaaaataaca ttggactttt tatgatataa
     6481 taaatgtctt agtaccaaca ca
//
LOCUS       NM_001127579            3579 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 1, mRNA.
ACCESSION   NM_001127579 XM_341827
VERSION     NM_001127579.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001127579.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166499.1, SRR26360172.1256701.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-191             JAXUCZ010000001.1  94931143-94931233   c
            192-359             JAXUCZ010000001.1  94930658-94930825   c
            360-487             JAXUCZ010000001.1  94928181-94928308   c
            488-591             JAXUCZ010000001.1  94928000-94928103   c
            592-674             JAXUCZ010000001.1  94926045-94926127   c
            675-829             JAXUCZ010000001.1  94925808-94925962   c
            830-1008            JAXUCZ010000001.1  94923695-94923873   c
            1009-1924           JAXUCZ010000001.1  94922695-94923610   c
            1925-2006           JAXUCZ010000001.1  94922525-94922606   c
            2007-3579           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3579
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            101..191
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2148
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 1"
                     /protein_id="NP_001121051.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNS
                     AMLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNP
                     DSNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGA
                     GDGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSG
                     PSPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPIS
                     APQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSAS
                     SRQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAK
                     VPPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGA
                     GDALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQK
                     RNVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <787..1674
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <787..1674
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1894..>2028
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    1894..>2028
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            192..359
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            360..487
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            488..591
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            592..674
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            675..829
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1008
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1924
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2006
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..3579
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tcagttttca cctcccaaga
      121 cagcccttgg aaatgttccc caaggtggac aaccctttag accatcaaga agccagaact
      181 ggagccacaa ggtctcaaaa gccacaagct cccaaggcca cagcagccaa ttctgctgag
      241 ctgtctgagg agtcctggcc atccagttca gggaccgctt ccccacccag taccactgag
      301 ggacagagta cctctccacc cctcacctta attgacaacg aggactcagt ggtggccaag
      361 tacataaacc ggttccgcaa agctcagccc acgagccgag aggaccgcca gcccgtgggc
      421 ccaaccccag ctgacttttg gtggctacag cctgcgtctt cagacctcag cagtcacctt
      481 gcagcagcag gagctggtga acctacagga agatctgccg tgacaggtcc atgtcccacc
      541 gggatgtcca gtacgtctct ggcttctgtg cctcttcaga gagtaaagca gagtctgaac
      601 tcttggaact cggctatgct ggagctggag accctgagcc ttcaaagccg agcggccaag
      661 ctgctggaac gcagcaaggc ctccctctcc tcctcctcct cctcccccag tcccaacgaa
      721 gccagcagct cctccttccc catcagctct gacggcctct ctccctgctc tgtgaccttc
      781 aatccggact ccaacaagag ttctagtccc aaagaacccg tgctgggagc agccccagtg
      841 ccatcccagg ccatccctgc accccgccca gcctctgccc aggcaaccct taagcctgag
      901 gaagacattt tataccaatg gaggcaacgg aggaagcttg agcagtctct acaaggtgca
      961 ggtgatggaa cctgggtgtt gcctcggaca ccagccctca ctactcagac tcctgtctct
     1021 gcagtgaatc ttggttccaa ggggacccaa cctaactgtg ctccaccatg gggcagtgtg
     1081 gcccagcctc ctcccccaca ggcattctat atggagaggc cacctctttc agggccctct
     1141 ccacacatct gggcccccgg cacacacggg gttctctggg ccccacaggc caatccctgg
     1201 atacctcttg ggatggttcc taccacactg ctaacctcca cccttgctcc cttggcctcc
     1261 ttaccagtac cacctacctc cacttcagct gccacagccc ccatctctgc tccccaggtc
     1321 tccatcccag ggcccccagc ctctgcccca cctccctgca cttctgcccc agcttccacc
     1381 gtcccactac ctgacaaccc ccagggacca accacccctg agttgagtag ctctgtccat
     1441 cccaagaagc tgagccccaa gcctcgctgt gtgagcgctt cgtctcgtca ggagactact
     1501 ggaccagaca ctgcagcttt cgagagtccc tgttctcagc ttaggggggc tctgagccag
     1561 gtagtgacag ctcggctgtt ctccgacagc ctggaggata tgcctccatc tgaagcagat
     1621 tcccggaaag tcaaggccac ctcctctcaa gccaaagttc cgccccctcc acctgagtcc
     1681 cggcgtgggt ccaagacaga gtcccgcaaa agtaaagtca ccctctcagc tgaagctggg
     1741 gatccacagc cggctacagc cccaaaggca tccacactgt cagaggtcca atcacttgaa
     1801 ttcaagaagt ctacacccaa gaagggagct ggtgacgcct tgactacggc cccgcctgcc
     1861 tcaagccacg ccccttccga ggacttgcta tcccaggccg ctagacttct gcaggctgcg
     1921 gaagactctg acggcagcga gtttccggaa gactctgtgt tgcgagtgct aagggctcag
     1981 agggcagaac taaggcagca gaaaaggaat gtggatgccc aattatccct cctcttggac
     2041 cacactgaag acccaggatt ttcatctcct ccagccaggt caccttccag ttccccaaga
     2101 atgcggttaa ggagggaagg agcctccctt gaggccagac gaccttgaat cataaacatt
     2161 gtttttcctg ggctggggag gtggctcagt gggtaaagca cttgcaagtg tgaagacccg
     2221 agtttagatc cccagaaccc acataaaggt aactgacagg ccagctggtc catggagaca
     2281 gggtctcaat caaggtggaa atcaaagacc aatctctgaa attctctgac ttccacacaa
     2341 gagctgtggg gtgtggtgca cataacacag gcacgcacac acaggcacac acacacacgg
     2401 acgcacacat gcgctcgcgc acgcacacac acacacacac acacatacac aggcacacac
     2461 actaaagttg tccccaatta atatttttcc agtttactgt taatctctaa gaaatgggtt
     2521 gttgtagaaa ggctgattgt gctaataagg aaatgtagct cttccctaac tactgaaaca
     2581 aagtttcttc tctctagccc tccttcccac cccctctctc tgatatccct ccccctctct
     2641 ctccccggga gcacatggct ctaggtaatg tgggcacctg acttatgcaa ctcagaagtg
     2701 gagttggaca tctcagatgg agacaaaggc cctgttatgt ggcactaaga aacatcagtg
     2761 ttggacaata catctctcat ctgagctggc atcctccctc tctgatggcc gtctccctcc
     2821 acgggctcac gatgcctcgg ttcccacagg tgcccagatt cctggtgttt ccccaagttc
     2881 gttctccttc acattcttca agactgtgct ctccctactc aggaccaaag tccttcgaca
     2941 gttagcctga ctcctcccct tccccacaca tagtcaggcg ctgactcggt ttgctttata
     3001 gttccccaga atccaactcc tttccgctgc cctcgcctca gtctaggctt cctcctacct
     3061 gtacagttga aggttcgcca ttactataaa cacatctgct ccctctttga tgcacttgcc
     3121 acccaggggg acagcctgtc tcttctcttt gaaactgagc ttttcaacaa atgcacctga
     3181 aagcctgagg cctctgtcag aaacatgggt tctgtcctcc cgttcttttt cttactttct
     3241 gtgactcaga tgcttttcag agtctgctat gaaacctgat tgctggacac ggaaacacac
     3301 acctgtaatc tcaggagtct gaggccagag gatctcactc tggggtcacc ctcatagtga
     3361 gtccctgtgt tgaaaaaaag agtcatgggg ctggagagat ggctcagtgg ttaagagcac
     3421 tgactgctct tccagaggtc ctgagttcaa ttcccagcaa ccacatggtg gctcacaacc
     3481 atctgtaatg ggatctgatg ccctcttctg gtgtgtctga agacaactac agtgtactta
     3541 tatataataa ataaataaat ctttaaaaaa gaaagaaaa
//
LOCUS       NM_001438055            1657 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            4, mRNA.
ACCESSION   NM_001438055
VERSION     NM_001438055.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1657)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1657)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 1657)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 1657)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 1657)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 1657)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 1657)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 1657)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 1657)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 1657)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR22582419.1807386.1, SRR21887621.940300.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000001.1  254838799-254839081 c
            284-386             JAXUCZ010000001.1  254829899-254830001 c
            387-431             JAXUCZ010000001.1  254829728-254829772 c
            432-507             JAXUCZ010000001.1  254829533-254829608 c
            508-610             JAXUCZ010000001.1  254829330-254829432 c
            611-783             JAXUCZ010000001.1  254829031-254829203 c
            784-906             JAXUCZ010000001.1  254828414-254828536 c
            907-990             JAXUCZ010000001.1  254828151-254828234 c
            991-1114            JAXUCZ010000001.1  254827934-254828057 c
            1115-1257           JAXUCZ010000001.1  254827580-254827722 c
            1258-1657           JAXUCZ010000001.1  254812800-254813199 c
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1657
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     CDS             259..1281
                     /gene="Ldb1"
                     /note="isoform 4 is encoded by transcript variant 4; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 4"
                     /protein_id="NP_001424984.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQK
                     SQLVNI"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
ORIGIN      
        1 acacactccg gggacgcaca cccgcgcgta cacacgcaga ggcagctcgc cttcctgcct
       61 ggcttccttc ctgtttgctc cgcgcctgac aggcccctcg ctgcaggcag gggcggcccg
      121 caccgggcaa aggccgggcc gggccggcgg cgcgggcaac gggggccgcg ggcggcggca
      181 gcggctcatg cccagcctgt ccctgcgagg ggcgggcatc gtgactcggc tgggccccca
      241 gcagcgggcg atgtgaagat gtcagtgggc tgtgcctgtc ctggttgttc ctcaaagtca
      301 ttcaagctgt actccccgaa ggagcccccg aacggcaacg ccttccctcc cttccatccc
      361 ggcaccatgc tggatcggga tgtgggccca actcccatgt acccacctac atacctggag
      421 cctgggatag ggaggcacac gccatatggt aaccagacag actatagaat atttgaactt
      481 aacaaacgac tacagaactg gacagaggag tgtgacaatc tctggtggga cgctttcacg
      541 accgagttct tcgaggatga tgctatgctg accatcactt tctgcctgga ggatggacca
      601 aagagatata ccattggccg gaccctgata ccacgctact tccgaagcat tttcgagggg
      661 ggtgctacgg agctgtatta cgtacttaag caccccaagg aggcattcca cagcaacttc
      721 gtgtccctcg actgtgacca gggcagcatg gtgacccagc atggcaaacc catgtttacc
      781 caggtgtgtg tggaaggccg gttgtacctg gagttcatgt ttgacgacat gatgcggata
      841 aagacatggc acttcagtat ccggcagcac agagagctca tccccaggag tatcctggcc
      901 atgcacgccc aggaccccca gatgttggat cagctctcca aaaacattac ccggtgtggg
      961 ttgtccaatt ccactctcaa ctacctccga ctctgtgtga tactggagcc catgcaggaa
     1021 ctcatgtccc gtcacaagac ctacagcctc agcccccgag actgcctcaa gacctgcctt
     1081 ttccagaagt ggcagcggat ggtagcacct cccgcggagc ctgcacgaca gcagcccagc
     1141 aaacggagga aacggaagat gtcagggggt agcaccatga gctcgggggg cggcaacacc
     1201 aacaacagca acagcaagaa gaagagccca gccagcacct tcgctctctc cagccagaaa
     1261 tcccagctcg tgaacatttg aagagtgaag ctggcagtga caagagatgc tcaccaggag
     1321 gcgccagtgc ctaagaagat actgaaaccc tgtatggagg ctccttcctg cggagactga
     1381 agtcccgtgc cctctaggat ctcataagga gttccaggcc agcttgggct acaaaggaga
     1441 taattcagcg gctaagattg ttgttgctct tgcagagaac ctgagctgga tttctagtat
     1501 ccgtgtagag tggctcacaa tcaattctaa cttcagttcc agggaatctc aaatgctctt
     1561 cccacctcgg atgggacatt tgcacacaca cacacacaca cacacacaca cacacacaca
     1621 cacacaaata aaaagtaatt ttttaagata tctgtaa
//
LOCUS       NM_001438107            3494 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 12, mRNA.
ACCESSION   NM_001438107 XM_063266471
VERSION     NM_001438107.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266471.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.246566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-191             JAXUCZ010000001.1  94931143-94931233   c
            192-359             JAXUCZ010000001.1  94930658-94930825   c
            360-487             JAXUCZ010000001.1  94928181-94928308   c
            488-588             JAXUCZ010000001.1  94928000-94928100   c
            589-671             JAXUCZ010000001.1  94926045-94926127   c
            672-826             JAXUCZ010000001.1  94925808-94925962   c
            827-1005            JAXUCZ010000001.1  94923695-94923873   c
            1006-1921           JAXUCZ010000001.1  94922695-94923610   c
            1922-3494           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3494
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            101..191
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2025
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 3 is encoded by transcript variant 12;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 3"
                     /protein_id="NP_001425036.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEGMWMPNYPSSWTTLKTQDFHLLQPGHLP
                     VPQECG"
     misc_feature    <784..1671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <784..1671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            192..359
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            360..487
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            488..588
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            589..671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            672..826
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1005
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1921
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..3494
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tcagttttca cctcccaaga
      121 cagcccttgg aaatgttccc caaggtggac aaccctttag accatcaaga agccagaact
      181 ggagccacaa ggtctcaaaa gccacaagct cccaaggcca cagcagccaa ttctgctgag
      241 ctgtctgagg agtcctggcc atccagttca gggaccgctt ccccacccag taccactgag
      301 ggacagagta cctctccacc cctcacctta attgacaacg aggactcagt ggtggccaag
      361 tacataaacc ggttccgcaa agctcagccc acgagccgag aggaccgcca gcccgtgggc
      421 ccaaccccag ctgacttttg gtggctacag cctgcgtctt cagacctcag cagtcacctt
      481 gcagcaggag ctggtgaacc tacaggaaga tctgccgtga caggtccatg tcccaccggg
      541 atgtccagta cgtctctggc ttctgtgcct cttcagagag taaagcagag tctgaactct
      601 tggaactcgg ctatgctgga gctggagacc ctgagccttc aaagccgagc ggccaagctg
      661 ctggaacgca gcaaggcctc cctctcctcc tcctcctcct cccccagtcc caacgaagcc
      721 agcagctcct ccttccccat cagctctgac ggcctctctc cctgctctgt gaccttcaat
      781 ccggactcca acaagagttc tagtcccaaa gaacccgtgc tgggagcagc cccagtgcca
      841 tcccaggcca tccctgcacc ccgcccagcc tctgcccagg caacccttaa gcctgaggaa
      901 gacattttat accaatggag gcaacggagg aagcttgagc agtctctaca aggtgcaggt
      961 gatggaacct gggtgttgcc tcggacacca gccctcacta ctcagactcc tgtctctgca
     1021 gtgaatcttg gttccaaggg gacccaacct aactgtgctc caccatgggg cagtgtggcc
     1081 cagcctcctc ccccacaggc attctatatg gagaggccac ctctttcagg gccctctcca
     1141 cacatctggg cccccggcac acacggggtt ctctgggccc cacaggccaa tccctggata
     1201 cctcttggga tggttcctac cacactgcta acctccaccc ttgctccctt ggcctcctta
     1261 ccagtaccac ctacctccac ttcagctgcc acagccccca tctctgctcc ccaggtctcc
     1321 atcccagggc ccccagcctc tgccccacct ccctgcactt ctgccccagc ttccaccgtc
     1381 ccactacctg acaaccccca gggaccaacc acccctgagt tgagtagctc tgtccatccc
     1441 aagaagctga gccccaagcc tcgctgtgtg agcgcttcgt ctcgtcagga gactactgga
     1501 ccagacactg cagctttcga gagtccctgt tctcagctta ggggggctct gagccaggta
     1561 gtgacagctc ggctgttctc cgacagcctg gaggatatgc ctccatctga agcagattcc
     1621 cggaaagtca aggccacctc ctctcaagcc aaagttccgc cccctccacc tgagtcccgg
     1681 cgtgggtcca agacagagtc ccgcaaaagt aaagtcaccc tctcagctga agctggggat
     1741 ccacagccgg ctacagcccc aaaggcatcc acactgtcag aggtccaatc acttgaattc
     1801 aagaagtcta cacccaagaa gggagctggt gacgccttga ctacggcccc gcctgcctca
     1861 agccacgccc cttccgagga cttgctatcc caggccgcta gacttctgca ggctgcggaa
     1921 ggaatgtgga tgcccaatta tccctcctct tggaccacac tgaagaccca ggattttcat
     1981 ctcctccagc caggtcacct tccagttccc caagaatgcg gttaaggagg gaaggagcct
     2041 cccttgaggc cagacgacct tgaatcataa acattgtttt tcctgggctg gggaggtggc
     2101 tcagtgggta aagcacttgc aagtgtgaag acccgagttt agatccccag aacccacata
     2161 aaggtaactg acaggccagc tggtccatgg agacagggtc tcaatcaagg tggaaatcaa
     2221 agaccaatct ctgaaattct ctgacttcca cacaagagct gtggggtgtg gtgcacataa
     2281 cacaggcacg cacacacagg cacacacaca cacggacgca cacatgcgct cgcgcacgca
     2341 cacacacaca cacacacaca tacacaggca cacacactaa agttgtcccc aattaatatt
     2401 tttccagttt actgttaatc tctaagaaat gggttgttgt agaaaggctg attgtgctaa
     2461 taaggaaatg tagctcttcc ctaactactg aaacaaagtt tcttctctct agccctcctt
     2521 cccaccccct ctctctgata tccctccccc tctctctccc cgggagcaca tggctctagg
     2581 taatgtgggc acctgactta tgcaactcag aagtggagtt ggacatctca gatggagaca
     2641 aaggccctgt tatgtggcac taagaaacat cagtgttgga caatacatct ctcatctgag
     2701 ctggcatcct ccctctctga tggccgtctc cctccacggg ctcacgatgc ctcggttccc
     2761 acaggtgccc agattcctgg tgtttcccca agttcgttct ccttcacatt cttcaagact
     2821 gtgctctccc tactcaggac caaagtcctt cgacagttag cctgactcct ccccttcccc
     2881 acacatagtc aggcgctgac tcggtttgct ttatagttcc ccagaatcca actcctttcc
     2941 gctgccctcg cctcagtcta ggcttcctcc tacctgtaca gttgaaggtt cgccattact
     3001 ataaacacat ctgctccctc tttgatgcac ttgccaccca gggggacagc ctgtctcttc
     3061 tctttgaaac tgagcttttc aacaaatgca cctgaaagcc tgaggcctct gtcagaaaca
     3121 tgggttctgt cctcccgttc tttttcttac tttctgtgac tcagatgctt ttcagagtct
     3181 gctatgaaac ctgattgctg gacacggaaa cacacacctg taatctcagg agtctgaggc
     3241 cagaggatct cactctgggg tcaccctcat agtgagtccc tgtgttgaaa aaaagagtca
     3301 tggggctgga gagatggctc agtggttaag agcactgact gctcttccag aggtcctgag
     3361 ttcaattccc agcaaccaca tggtggctca caaccatctg taatgggatc tgatgccctc
     3421 ttctggtgtg tctgaagaca actacagtgt acttatatat aataaataaa taaatcttta
     3481 aaaaagaaag aaaa
//
LOCUS       NM_001108475            2226 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 2, mRNA.
ACCESSION   NM_001108475 XM_001075571 XM_341799
VERSION     NM_001108475.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001108475.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168841.1, SRR21887621.1410644.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  88052773-88053076   c
            305-479             JAXUCZ010000001.1  88045950-88046124   c
            480-645             JAXUCZ010000001.1  88045709-88045874   c
            646-730             JAXUCZ010000001.1  88043417-88043501   c
            731-768             JAXUCZ010000001.1  88042666-88042703   c
            769-1010            JAXUCZ010000001.1  88042312-88042553   c
            1011-1108           JAXUCZ010000001.1  88042068-88042165   c
            1109-1160           JAXUCZ010000001.1  88040749-88040800   c
            1161-1197           JAXUCZ010000001.1  88040554-88040590   c
            1198-1243           JAXUCZ010000001.1  88040283-88040328   c
            1244-1334           JAXUCZ010000001.1  88040092-88040182   c
            1335-1392           JAXUCZ010000001.1  88038970-88039027   c
            1393-2226           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2226
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..304
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     CDS             300..1430
                     /gene="Vasp"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 2"
                     /protein_id="NP_001101945.2"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MSNETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPT
                     ANSFRVVGRKLQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQ
                     FAIGMANALEALEGGGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPP
                     APPAGGPPPPPGPPPPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGS
                     GAPGLAAAIAGAKLRKVSKEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQV
                     GEKPPKDESASQEESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSS
                     SDDSDLERVKQELVEEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    945..1016
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    945..1016
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1317..1415
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1317..1415
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            305..479
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            646..730
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            731..768
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1010
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1108
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1160
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1197
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1243
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1334
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1392
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2226
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtagtaa gagtaaccgc gtaggtgctg ccggctgagg gggtgcgccg gcgaggttcg
       61 gacgctgcac cccgctttcc atcgcagggg atcccagcac atcagagcac cggagggagg
      121 aggcgcctga gcacccgccc gggcccggtc cacgttctcc ccaggaagct ggactctatg
      181 gggcgggacc ccgagagaga ctgagcagaa cctggagcca gccccgcacc cctgcacttc
      241 caatcagggg cgccccggga gcactccccg tgggcgcgcc gcctgccctc tgcgcagcca
      301 tgagcaacga gacggtcatt tgttccagcc gggctactgt gatgctttac gatgacagca
      361 acaaacgatg gcttcctgct ggcaccggtc cccaggcctt tagccgcgtc cagatctacc
      421 acaaccccac tgctaactct ttccgagttg ttggccgcaa gctgcagcct gaccagcagg
      481 tggttatcaa ctgtgccatc attcgaggtg tcaagtacaa tcaggccact cccatattcc
      541 accagtggcg tgatgcccgc caggtctggg gcctcaactt cggcagcaag gaggacgctg
      601 cgcagtttgc gatcggcatg gccaatgccc tggaggcctt ggaaggaggt gggcctcccc
      661 ctgccccagc accccctgcc tggtctaccc agaatggccc ctccccagag gagctggaac
      721 aacagaaaag gcagcctgaa catttggagc gccgggtctc caatgcagga ggcccacctg
      781 ctcccccagc tgggggccca cctccacctc caggacctcc ccctcctccg ggtccccccc
      841 cacccccagg tctgcccccc tcaggggtat ctggggcagg tcatggaaca ggtgtagccc
      901 caccccctgc acccccactc cctacagcac agggccccag tagtgggggt tccggggccc
      961 caggcctggc cgctgccatt gctggagcca aactcaggaa agtgagcaag gaggaggcct
     1021 ctggggggcc cctggccccc aaagctgaga atagtcgagg cactggtggg gggcttatgg
     1081 aagagatgaa cgccatgctg gcccggagaa ggaaagccac acaggttggg gagaagcccc
     1141 ccaaagacga gtcagccagt caggaggagt cagaggcccg aatccctgcc caaagtgaac
     1201 ctgtgcgaag accctgggag aagaacagca caaccttgcc aaggatgaag tcatcctctt
     1261 ctgtgactac ctccgaggcc cacccctctg tgcccagctc cagtgatgac tccgacttgg
     1321 agagggtgaa gcaggagctt gtggaagagg tgcggaagga gctacagaaa atgaaagagg
     1381 aaataatcga agtctttgtc caggagctga ggaagcgggg ttctccttga ctacagggac
     1441 ccagaagacc catttcttct ttttgtactt cctgcctggc acctgctttc cctgcctcaa
     1501 cttgaccaag agttacacaa gaatgcgttc tcccctacca gctcccactt ggaagattcc
     1561 acaggggtgt ggcttcctgg tgccgtggtc acacccacgc tggctgctga ttggataagg
     1621 aggtcccacc cctttgttcc ctttggtcct tccccttcac catccccttg gagctggttc
     1681 ctctgctggg gatgtaagag taaccccaca gtaagggaag gaaggagggg atctcacctt
     1741 ctcttgttct ggattcactt taacgcttta atgccttgga attttttttt ttaagaaaaa
     1801 gtatatatat atatttgggt tttgtggggg gaagggaaat tttttgttct ctttggtttt
     1861 gataaaatgg ggtgtgggag tttttaaatg ctatacccca agctttgtcc catcagaggc
     1921 agctatgtaa gaggaggggt atcccaccaa gtagggggca tttcccccac ccctgggata
     1981 cctccccatt tgccttggct cctctctctt ttctataagg aattaagatt ctttaacttt
     2041 tttggaacct cagttttgtg gtttttttta tttgggttag gatttcaggg tccagaccat
     2101 ttttgccctc caggaagacg aagtgagggg gaggagaaga ggaaaaatag gtcctccgac
     2161 ttctacacca tagcttcttg gacacgggcc ctcgctgaat aaatctgcag tttttataaa
     2221 tgcaaa
//
LOCUS       NM_001191634            6415 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 4, mRNA.
ACCESSION   NM_001191634 XM_219953
VERSION     NM_001191634.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6415)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6415)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6415)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6415)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6415)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6415)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6415)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6415)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6415)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6415)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001191634.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5862.1,
                                           SRR26643295.6953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-1046            JAXUCZ010000001.1  255060666-255060813
            1047-1270           JAXUCZ010000001.1  255061098-255061321
            1271-1436           JAXUCZ010000001.1  255062208-255062373
            1437-1648           JAXUCZ010000001.1  255063221-255063432
            1649-1747           JAXUCZ010000001.1  255063987-255064085
            1748-1942           JAXUCZ010000001.1  255069136-255069330
            1943-2132           JAXUCZ010000001.1  255069541-255069730
            2133-2273           JAXUCZ010000001.1  255069954-255070094
            2274-2362           JAXUCZ010000001.1  255070390-255070478
            2363-2565           JAXUCZ010000001.1  255071464-255071666
            2566-2689           JAXUCZ010000001.1  255072193-255072316
            2690-2815           JAXUCZ010000001.1  255072589-255072714
            2816-2898           JAXUCZ010000001.1  255072981-255073063
            2899-3135           JAXUCZ010000001.1  255073935-255074171
            3136-3229           JAXUCZ010000001.1  255074448-255074541
            3230-3406           JAXUCZ010000001.1  255074797-255074973
            3407-3471           JAXUCZ010000001.1  255075722-255075786
            3472-3595           JAXUCZ010000001.1  255075873-255075996
            3596-3667           JAXUCZ010000001.1  255076149-255076220
            3668-3762           JAXUCZ010000001.1  255076331-255076425
            3763-3916           JAXUCZ010000001.1  255076801-255076954
            3917-4142           JAXUCZ010000001.1  255081461-255081686
            4143-4303           JAXUCZ010000001.1  255082250-255082410
            4304-4550           JAXUCZ010000001.1  255082513-255082759
            4551-4756           JAXUCZ010000001.1  255082874-255083079
            4757-4907           JAXUCZ010000001.1  255085207-255085357
            4908-5038           JAXUCZ010000001.1  255085463-255085593
            5039-5140           JAXUCZ010000001.1  255085758-255085859
            5141-5254           JAXUCZ010000001.1  255086114-255086227
            5255-5435           JAXUCZ010000001.1  255086358-255086538
            5436-5564           JAXUCZ010000001.1  255086830-255086958
            5565-6415           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6415
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5845
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 4 is encoded by transcript variant 4;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 4"
                     /protein_id="NP_001178563.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVMPGSELPTPNGAALSSNLTGGMPFIEAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQAGSPREITTTEPGSTEIGVSDQL
                     DPQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPRGVRFTQSSQKE
                     GTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLL
                     GLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITV
                     ENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPV
                     SGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTYK
                     SERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPPR
                     FSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWL
                     RENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVI
                     HRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRK
                     NLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGATPEGIF
                     LRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSD
                     VFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNI
                     MEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGP
                     EQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEE
                     TYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLL
                     RLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDD
                     WATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS
                     EVYTDHGRPGKMHRSATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLT
                     VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQD
                     KRGKSHKYDSKGNRFKKKPKEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVSL
                     QVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGRKIEADSRTLWAHCWCPLLQGIA
                     CLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPAD
                     VGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEA
                     VPESLKNMLLVMDTAEIFHSADARGGSPSALWEITWERIDCFLPHLRDELFKQTVIQD
                     PMPTEPHSQKPLASTHLTPAAGDPRMPGHPPPPEIPSEVGACDPEKPESTRAASSSSP
                     GSPVASSPSKQSPAPEGPPPLAQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSP
                     VPLLATPRPTDPIPTSEVN"
     misc_feature    <1544..>3793
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1544..>3793
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2354..2911
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2354..2911
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5444..5836
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5444..5836
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1270
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1436
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1648
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1747
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1942
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2132
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2273
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2362
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2565
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2689
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2815
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3135
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3229
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3406
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3471
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3595
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3667
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3762
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3916
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4142
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4303
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4550
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4551..4756
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4907
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4908..5038
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5140
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5141..5254
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..5435
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5436..5564
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..6415
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagct
      901 gaaaatgaga gcaggaggca tgagtgactc atccaagtgg aagaaacaga agcgatcccc
      961 tcgacctcca cgtcatacaa ccaaagtcat gccaggttca gagctgccca ccccaaatgg
     1021 agccgcctta tcctctaacc ttactggtgg catgcccttc attgaggcac ccacatccat
     1081 ctcctctgca agttcagaag ctgcctccac agtggtcagt ccctgtacag atagtggcct
     1141 ggaattatcc tcccaggcta cctccaagga ggacctcacc gacctggagc aagctggctc
     1201 cccaagggag atcaccacca cagagcctgg gagcactgag ataggagttt ctgatcagct
     1261 tgaccctcag gaaggggccc atgtagaaaa ggcccagtca gcatcggtgg aatctatccc
     1321 tgaagtgcta gaggagtgca catcccctac tgaccattct gactctgcct ctgtccatga
     1381 catggattat gtcaatcctc ggggcgtgcg ctttacccag tcctcccaga aagaaggcac
     1441 agctttggtt ccttatggtc ttccttgcat ccgtgagctc ttccgcttcc ttatctccct
     1501 cacaaatcca catgaccgcc ataactctga ggttatgatc cacatgggac ttcatttgct
     1561 gacagtagct cttgagtcag cccctgtggc ccagtgccag accctcttgg gtctcatcaa
     1621 ggatgagatg tgccgacact tattccagct actcagcgta gagcggctga acctttacgc
     1681 tgcttcccta cgagtgtgct ttttgctctt tgagagcatg cgggaacacc tcaagttcca
     1741 gttggagatg tacatcaaaa agctcatgga gattatcact gttgaaaacc ccaagatgcc
     1801 ttatgagatg aaggagatgg cgctggaggc cattgtgcag ctctggcgca tccccagctt
     1861 cgtcacggag ctctacatca actatgactg tgactactac tgctccaacc tcttcgaaga
     1921 cctcactaag ctgctgtcca agaatgcctt tcctgtgtct ggccagcttt atacaacaca
     1981 cctgctgtct cttgatgccc tattgacagt tattgacagc actgaggctc attgtcaggc
     2041 caaagtcctc aacaccctca accagcaaga gaagaaagag acagccagac ctggctttga
     2101 ggcagtggat ggcagcccag acacttacaa gtctgagaga gcagccagtg atgggaaagc
     2161 cacaggagtg ccctcagatg ctccaggcct tcatttttca agtggagggt ggttgtcaac
     2221 agaacatgga aagccagggt gcagtgatct ggaggaagct ggtgactctg gggttgacaa
     2281 aaagaccacc aggaagccac ctcgattttc ctgtcttctg ccagatccac gggaactaat
     2341 tgaaattaaa aacaaaaaaa agctgctgat cactggtaca gagcagttca accaaaaacc
     2401 aaagaagggg atccagtttc tgcaggagaa aggcctcctc accatcccaa tggataacac
     2461 agaggtagcc cagtggctcc gagaaaaccc tcggctagac aaaaaaatga ttggagagtt
     2521 tgtgagtgac cgcaaaaaca tggacctgtt ggagagtttt gtgagcacct tcagcttcca
     2581 gggtctgagg cttgatgagg ctctccgcct ctacctagaa gccttccgtc tgcctgggga
     2641 agcgcctgtt attcacaggc tgctggaggt gttcactgag cactggagga gttgtaatgg
     2701 ctccccattt gctaatagcg atgcctgctt tgccctggcc tatgctgtta tcatgcttaa
     2761 cactgaccaa cataaccaca atgttcgcaa gcaaaatgca cccatgaccc tggaggagtt
     2821 ccgcaaaaac ctgaaaggtg tgaatggagg caaggacttt gagcaagaca tcctggaaga
     2881 catgtaccat gccatcaaga atgaggaaat tgtgatgcct gaggaacaaa caggtctggt
     2941 tcgtgagaat tatgtgtgga gtgtgctgct tcatcgaggt gctacccctg agggcatctt
     3001 ccttcgtgta ccccctggca gctatgatct tgacctcttc actatgacct ggggccccac
     3061 tattgctgct ctctcttatg tgttcgataa aagcctcgag gagaccatca tccagaaagc
     3121 catctcaggc ttcaggaagt gtgccatgat ctccgcccac tatggcctca gcgatgtgtt
     3181 tgacaatctc atcatctctc tgtgcaaatt cacagctcta agtagtgagt ctattgagaa
     3241 cctgcccagt gtattcggaa gcaaccctaa agcccacatt gcagccaaga cagtattcca
     3301 tttggcccat cgtcatggtg acatccttcg ggagggctgg aagaatatca tggaggccat
     3361 gctgcagctc ttccgagccc aacttttacc gaaggctatg gtagaggtag aagattttgt
     3421 ggatcccaat ggtaagatct ctctacagcg ggaggagaca ccatcaaacc gaggagagtc
     3481 aacagtcctt agttttgtaa gctggctgac actgagtggt cctgagcagt ccagtgtccg
     3541 gggcccatcg acagagaacc aagaggccaa gcgagtagcc ttggactgca tcaagcaatg
     3601 tgacccagaa aagatgatca cagaaagcaa gttcctccag ctggaatctc tgcaggagct
     3661 catgaaggct ctggtctcgg tgacaccaga tgaagagaca tatgatgaag aagatgctgc
     3721 tttctgtctg gagatgctgc taaggattgt gttagaaaac agggaccgtg tgggctgtgt
     3781 atggcagact gttcgagatc atctatacca cctgtgtgtt caggcacaag atttctgctt
     3841 ccttgtggag cgagcagtgg tagggctgct acgcctagcc attcggctac tccgaagaga
     3901 agagattagt ggccaggtcc tgctctctct gcgcatcttg ttactgatga agcccagcgt
     3961 gctgtccaga gtcagccacc aggtcgctta tgggctgcat gaactcctca agaccaatgc
     4021 tgccaacatc cactcgggtg atgactgggc cactctcttc acattgctgg agtgcattgg
     4081 ctcaggcgtg aagcctccag atgctctaca agccacagcc agggctgatg ctcctgatgc
     4141 tggagcacaa tccgacagtg agctcccatc ctaccatcaa aatgatgtca gcctagaccg
     4201 agggtacact tccgactcag aagtctacac tgaccatggc aggcctggca agatgcaccg
     4261 atcagccaca gacgctgaca tggccaacag tggttggtta gtggtgggga aggatgacat
     4321 tgataactcc aaaccagcag caggactcag caggccaggc ccttcgccct tggtcaatca
     4381 gtacagcctt acagtgggcc tggacctggg accacatgac actaagtcct tgcttaagtg
     4441 tgtggagtct ctgtccttca ttgttcgtga tgctgctcac atcacccctg acaactttga
     4501 actctgcgtc aagaccctcc gcatctttgt agaagccagt ctgaatggtg ggtgcaagtc
     4561 ccaggataaa cgtggcaaga gtcataaata tgacagcaaa gggaaccggt tcaagaaaaa
     4621 gcccaaggag ggctcgatgc ttcggcggcc ccgggcatcc agccagcatg ccactcgggc
     4681 tggacacagt gatgaagagg aggacgaagg cgtgcctgcc agctaccata cggtgtcttt
     4741 acaggtcagt caggacttgc tagacctgat gcacaccctg cacacacggg cagcctctat
     4801 ctacagttca tgggcagagg agcaacgcca cctggagaca ggtggccgga agattgaagc
     4861 tgactcacgt accctctggg cccactgctg gtgcccttta ttacaaggta tcgcttgctt
     4921 atgctgtgac gcccggcgcc aggtgcggat gcaggccctg acatatctcc agcgagccct
     4981 tctggtacat gacctgcaaa agctagatgc cctggaatgg gagtcctgtt ttaacaaggt
     5041 gctgtttccg ctactgacca agcttttaga aaatatcagc cctgcggatg tgggcgggat
     5101 ggaggagacc cggatgcggg cttccacact gctctcaaag gtcttcctgc agcacctgtc
     5161 cccactgctg tccctgtcca cctttgctgc cctgtggctc accatcctgg acttcatgga
     5221 caagtacatg cacgcaggtt ccagtgactt gctgtcagaa gctgtccctg agtctctgaa
     5281 gaacatgctc cttgtgatgg acacagcaga gattttccac agtgcagatg caaggggagg
     5341 cagcccctct gctctctggg agatcacctg ggagcgcatc gattgcttct taccacacct
     5401 acgtgatgaa ctcttcaagc agactgtcat ccaggacccc atgcccacag agcctcacag
     5461 tcaaaaacct ctggcttcta ctcacctgac gcctgctgct ggtgacccca ggatgcctgg
     5521 ccatccacct cctccagaga taccctcaga agtgggagct tgtgacccgg agaagcccga
     5581 gagcaccaga gctgccagca gcagctcccc tggatcgccg gtggcctcta gccccagcaa
     5641 acagagtcct gccccagagg gacctccccc actggcccag cccccactaa tcctacagcc
     5701 cttgacctcc ccactgcagg tgggggtacc acccatgact ttgcccatca tcctcaaccc
     5761 tgcactcatt gaggccacct ctccagtgcc tctcttagcc acgccacgcc ctacagaccc
     5821 catccccacc tctgaggtca actaaggcag ccactcagag gtcaggacca ttccttccta
     5881 tcaggcattc aaggccctgc ttccagtccc aggggccaca gaaatcttca ggcccaaagc
     5941 aagctgctgt taccactgct tgacaggggg atgacgatgt ttatagtccc tgctgggatc
     6001 cactccaggc tgcgaggttc ttcctctgcc gttcagtcct gaacttccaa gctgagagtg
     6061 gatgcaggct gaacctgtag cctctgcctc tggcctggca gccctgggga ggcatagagc
     6121 caaccctgct gtgccaaccc tgcagtgcct gccatgtgcc ccctgccagg ttgggcatta
     6181 ggagccaagc ccgacctctc tgcactttgt tcctctccct atccagtcca tcagtcctgg
     6241 gccactgcct ccagttcttc ttccttcatt aaatagttgg tcagtttgga gtcgcttggc
     6301 accatggagg gtggacaggt aggactcgat ggggggtctg cccacaggag catgtacata
     6361 tggaaaaata acattggact ttttatgata taataaatgt cttagtacca acaca
//
LOCUS       NM_001438044            6215 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus cell migration inducing hyaluronidase 2 (Cemip2),
            transcript variant 3, mRNA.
ACCESSION   NM_001438044 XM_006231166
VERSION     NM_001438044.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6215)
  AUTHORS   Wu,M., Wang,C., Gong,Y., Huang,Y., Jiang,L., Zhang,M., Gao,R. and
            Dang,B.
  TITLE     Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury
  JOURNAL   Int J Mol Med 52 (6) (2023)
   PUBMED   37888730
  REMARK    GeneRIF: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury.
REFERENCE   2  (bases 1 to 6215)
  AUTHORS   Yamamoto,H., Tobisawa,Y., Inubushi,T., Irie,F., Ohyama,C. and
            Yamaguchi,Y.
  TITLE     A mammalian homolog of the zebrafish transmembrane protein 2
            (TMEM2) is the long-sought-after cell-surface hyaluronidase
  JOURNAL   J Biol Chem 292 (18), 7304-7313 (2017)
   PUBMED   28246172
REFERENCE   3  (bases 1 to 6215)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6215)
  AUTHORS   Zhao,Q., Peng,L., Huang,W., Li,Q., Pei,Y., Yuan,P., Zheng,L.,
            Zhang,Y., Deng,J., Zhong,C., Hu,B., Ding,H., Fang,W., Li,R.,
            Liao,Q., Lin,C., Deng,W., Yan,H., Hou,J., Wu,Q., Xu,T., Liu,J.,
            Hu,L., Peng,T., Chen,S., Lai,K.N., Yuen,M.F., Wang,Y., Maini,M.K.,
            Li,C., Li,M., Wang,J., Zhang,X., Sham,P.C., Wang,J., Gao,Z.L. and
            Wang,Y.
  TITLE     Rare inborn errors associated with chronic hepatitis B virus
            infection
  JOURNAL   Hepatology 56 (5), 1661-1670 (2012)
   PUBMED   22610944
REFERENCE   5  (bases 1 to 6215)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 6215)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231166.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5227.1,
                                           SRR26360186.1614737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000001.1  228756849-228756940
            93-435              JAXUCZ010000001.1  228772412-228772754
            436-576             JAXUCZ010000001.1  228777206-228777346
            577-1138            JAXUCZ010000001.1  228777734-228778295
            1139-1308           JAXUCZ010000001.1  228781911-228782080
            1309-1497           JAXUCZ010000001.1  228785811-228785999
            1498-1667           JAXUCZ010000001.1  228788159-228788328
            1668-1877           JAXUCZ010000001.1  228788815-228789024
            1878-2083           JAXUCZ010000001.1  228789282-228789487
            2084-2153           JAXUCZ010000001.1  228789621-228789690
            2154-2282           JAXUCZ010000001.1  228792749-228792877
            2283-2371           JAXUCZ010000001.1  228796025-228796113
            2372-2503           JAXUCZ010000001.1  228801689-228801820
            2504-2539           JAXUCZ010000001.1  228802972-228803007
            2540-2695           JAXUCZ010000001.1  228803962-228804117
            2696-2873           JAXUCZ010000001.1  228807517-228807694
            2874-3089           JAXUCZ010000001.1  228809465-228809680
            3090-3298           JAXUCZ010000001.1  228812945-228813153
            3299-3481           JAXUCZ010000001.1  228818638-228818820
            3482-3701           JAXUCZ010000001.1  228821174-228821393
            3702-3800           JAXUCZ010000001.1  228824119-228824217
            3801-3955           JAXUCZ010000001.1  228827926-228828080
            3956-4059           JAXUCZ010000001.1  228831248-228831351
            4060-6215           JAXUCZ010000001.1  228831759-228833914
FEATURES             Location/Qualifiers
     source          1..6215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..6215
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="cell migration inducing hyaluronidase 2"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
     exon            1..92
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..435
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    93..95
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="upstream in-frame stop codon"
     CDS             105..4256
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /EC_number="3.2.1.35"
                     /note="transmembrane protein 2; cell surface
                     hyaluronidase"
                     /codon_start=1
                     /product="inactive cell surface hyaluronidase CEMIP2"
                     /protein_id="NP_001424973.1"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
                     /translation="MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPFRPAPPPKNH
                     ASAKLTSRSQEAPATFAFSPEEQRTPREDRKQKRHKNTFICFAITSFSFFVTLAVILG
                     ISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDMLRLTSDATVNSIVIQDGGLL
                     VFGDDKDGSRNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDEHESMPTFG
                     KKFIGVEAGGTLELHGARRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDT
                     ARVLEHEKFDTHEYHNESRRLQEFLRAQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRL
                     GSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFS
                     VTAYSEWIEGISLSGFRVDIADGVKLHLLDDVSSWGAGDRIVVASTDYSMYQAEELTL
                     LPCPECSRFQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGETEDSCYADNHC
                     QFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHLGRYPVHFHLCGDVDSKGGYRVP
                     TSVNGLSIHHSFSRCITVHGSSGLLIKDTIGFDTLGHCFFLEDGVEQRNILFHNLGLL
                     TKPGTLLPTDRNSSMCTVMRDGVFGNYIPVPTTDCMAVSTFWIAHPNNHLINNAAAGS
                     QDAGIWYLFHKEPTGESSGMQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNS
                     SASDPREYLCLDNSARFRPHQDADPEKPRVAAVIDRLIAFKNNDNGAWVRGGDIIVQN
                     SAFADNGKGLTFASDGSFPSDEGSSQEVSESLFVGESKNYGSQGGQNKYMGTGGIDQK
                     PRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNN
                     VSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYL
                     IRHPNCVSVTKWNAVVCSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAI
                     SPQYQPVVMLEKGYTIHWSGPAPRTTFLYLVNFNKDDWIRVGLCYPSNTSFQVTVGFL
                     QRQNGSLSRIEEYEPAQSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSS
                     QGCERVKIQAATDSKDMSNCMAKAYPQYYKKPSAVKRMPAMLTGFCQGCGTHQMVFSS
                     DPHKSYLPVRFQSPGKAEIQRGEPSVISVNGTDFTFRSAGAFLLIVDACSVPFRLTEK
                     RMFLSADISHLEEYLKASIPPRSIVLLSTRGEIKQMNISDSFVLLGLAKPAHLYNKGS
                     TVFLGFSGNFTPSWTRLFTSPDVQGLGVLEQYLPLQMEEYGCSRTSSVHRRDLELLQQ
                     ALKGL"
     misc_feature    498..836
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    498..836
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    762..1265
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    762..1265
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    3834..4088
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     misc_feature    3834..4088
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     exon            436..576
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..1138
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1308
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1497
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1667
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1877
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2083
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2153
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2282
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2371
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2503
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2539
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2695
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2873
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3089
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3298
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3481
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3701
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3800
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3955
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4059
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..6215
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctgctc caagcttcca acagggacgg tctgcaagaa cacactgcct ctgcggagag
       61 ggctacgact ccagctctcc cttgctggtc agtgacaggg tatcatgtat gcggctggtt
      121 ccaggggaca ctcccctgct ttcctgcaac ctcaaaacgg aaacggccac cgctcacctg
      181 gttatgttcc cgggaaagtg gttccctttc ggcctgctcc tcctccaaag aaccacgcct
      241 cagccaaact gacctccagg agccaagaag ccccagcaac ctttgctttc tcccccgagg
      301 agcagcgaac tccgagggag gaccgaaagc agaagagaca caagaacacc ttcatctgct
      361 ttgccataac cagcttctcg ttttttgtga cgctcgcagt cattttggga atatcctcca
      421 aatatgctcc agatgagaat tgtccagatc aaaaccctcg tctcaggaac tgggatccag
      481 gacaagattc tgcgaaacac attgttatca aggaggggga tatgcttcgc ctgacctcag
      541 atgctacagt gaattctata gtcattcagg atggaggact gcttgtgttt ggggatgaca
      601 aagacggatc caggaatata actttgagga ctcgatacat cctgatacag gatggtgggg
      661 cgcttcatat tggagcagaa aaatgccgct atcgatccaa agcgacaatt accttgtacg
      721 gcaagtcaga cgaacatgaa agtatgccaa catttggcaa gaagtttatt ggcgtggagg
      781 ctggcgggac actggagtta catggggctc ggaggacatc atggacgatg ctggcgagga
      841 ctctgcattc ctcgggcttg ccctttggct cctacgcctt cgaaaaggac ttctcccggg
      901 gccttaatgt gagggtcatt gaccaagaca cagctagagt tttagaacac gagaagtttg
      961 acacccatga gtaccacaac gagagcagga gacttcagga atttttgaga gctcaggatc
     1021 ccggccgcat tgttgctatt gctgttggag attcagccgt caagagcctg ttacagggaa
     1081 ccatccagat gatccaggac cggttgggaa gtaagctgat ccaaggcctg ggctacaggc
     1141 aagcttgggc tttagttggt gtcatcgatg gtggaagttc ttcctgcaat gaatctgtga
     1201 gaaactatga aaaccacagc actggtggca aggccctagc acaaggagaa ttctacaccc
     1261 tggatggtca gaagttctct gtgacagctt acagtgaatg gattgaagga atttcccttt
     1321 cgggtttccg ggtggacatt gcggatggag tgaagcttca cctgttggac gatgtcagca
     1381 gttggggagc cggagaccgg attgtggttg cgagcaccga ctattccatg taccaggcag
     1441 aggagctgac gcttctgccc tgccccgagt gcagccgttt tcaggtcaaa gttaaagaga
     1501 tcccccagta cctgcacgtt ggtgagatca tagacgggat agacatgaga gcggaggttg
     1561 gacttctcac ccggaacatt gtgatccaag gagaaacgga ggactcatgc tacgctgata
     1621 atcactgcca gttctttgat tatgacacct ttgggggaca tgtcatgata gagaagaatt
     1681 ttacttcagt ccatctgtct tatgtggagt tgaagcacat gggccagcag catctgggac
     1741 gctatcctgt gcattttcac ctgtgtggag atgtggattc taaaggaggg taccgagtgc
     1801 caacgtctgt gaacggcctg tctattcatc acagcttttc aaggtgcatc actgtgcacg
     1861 ggtccagtgg cttgctcatc aaagacacca ttggattcga caccctaggt cattgcttct
     1921 ttttggaaga tggtgttgaa cagagaaaca ttttgttcca taacctgggg cttcttacca
     1981 agccgggcac tctcctcccc accgacagga acagctccat gtgcaccgtc atgcgtgatg
     2041 gagtgtttgg aaactacatc cccgtgccta ccacagattg tatggctgtt tcaactttct
     2101 ggattgccca ccccaacaac catctgatca ataacgcagc tgcaggctca caggatgctg
     2161 gaatatggta tttattccac aaggaaccaa ctggggaatc cagtggaatg cagctcctgg
     2221 agaagccaga actcacgcca ctgggaatat tttataacaa cagggttcat tcaaatttta
     2281 aggctggttt atttgttgac aaaggtgtca aaacgaccaa ctccagtgcc tctgacccaa
     2341 gggagtacct gtgtctggat aacagtgcaa ggtttcggcc ccatcaggat gcagaccctg
     2401 aaaagccacg agttgcggct gtcatcgaca gactcattgc ttttaaaaac aatgacaatg
     2461 gtgcctgggt ccgaggagga gacattattg ttcagaattc agcatttgca gataacggga
     2521 aggggttgac ctttgccagt gatgggagct tcccaagcga tgaagggtcc agccaggaag
     2581 tgtcggagtc cctctttgtc ggggagagta agaattacgg ctctcagggt ggccagaaca
     2641 agtacatggg cacaggggga atagaccaga agcctcggac gctacctagg aacaggacat
     2701 tcccaatccg aggctttcag atttatgacg ggcctattca tctcacaaag agcacgttca
     2761 aaaaatatgt gccaactcca gacaggtaca gcagcgcaat cggcttcctc atgaagaatt
     2821 cctggcagac aacacccagg aataacgtct ctcttgtgaa gtttggtcca caggtctctc
     2881 tgaacgtctt ctttggaaag cctggcccct ggtttgagga ttgtgagctg gatggtgata
     2941 agaactccat cttccacgac attgatggct ctgtgacagg atacaaggac acctatgtag
     3001 gaaggatgga caactacctg atccgccatc caaactgtgt cagcgttact aagtggaatg
     3061 cagtggtctg cagtgggacc tatgcccagg tgtatgttca gacgtggaac acgccgaatc
     3121 ttagcatgat catcacgcga gacgaatacc catcccaccc aatggtgctt cggggcatta
     3181 accagcgggc catctcccca cagtaccagc ctgtcgtcat gctggagaag ggctacacca
     3241 tccactggag tggcccagcg ccacgtacca ctttcttgta cctcgtgaac ttcaacaagg
     3301 atgactggat ccgggtcggc ctctgttacc cgtccaacac gagctttcag gtgaccgtgg
     3361 gctttctgca gcggcagaac ggctccttat ccagaatcga ggagtacgag cctgcgcagt
     3421 cgatggagga gctgcagaag aagccgtctg agagaaaatt ctactttgac tctggcacag
     3481 ggttattgtt tctgtatctc agagcccaca gccacagaga tggccacagt tactgttcat
     3541 ctcagggatg tgaaagagtc aagattcagg cagccacaga ctccaaagat atgagtaact
     3601 gcatggccaa agcgtaccca cagtattaca agaaaccctc ggcagtcaag cgcatgccag
     3661 ccatgctcac cgggttctgt caaggctgtg gcacccacca gatggtgttc agcagtgacc
     3721 ctcacaagag ctacctccct gttcgattcc agtcccctgg gaaagcagaa attcaacgtg
     3781 gagaaccatc tgttatttcc gtcaatggta ctgactttac cttccggagt gcaggtgcct
     3841 tcctcctcat tgtggatgcc tgcagtgtgc ccttccggtt gacggaaaag cggatgttcc
     3901 tttctgcaga catcagtcac ttggaagaat atctaaaggc tagcatccct ccaaggtcaa
     3961 tcgttctctt gagcacaaga ggagaaatca agcagatgaa tatctcggat tcattcgtgc
     4021 ttctgggact ggccaagcca gcacatctgt acaacaaagg tagtactgta tttttgggat
     4081 tcagcggaaa cttcacccca tcgtggacta ggctgttcac cagtcctgat gtgcagggcc
     4141 tcggggtgct cgagcagtat ctccccctgc agatggagga atatgggtgc tccaggacca
     4201 gcagtgtcca cagaagggac cttgaactgt tacagcaggc tttgaaaggg ctttaaagac
     4261 ttgcctgtaa tttaagtgct gggaaagaaa agaaaatgtg aactaactta tttaatttat
     4321 ggcattttaa gacaacactg ttaacccgat ggaaccattt tcttgttttg atacagaagg
     4381 gagagaaaga actcaaagca gttgcttgag tgccggtttg tgcactgtgg cgttgtgcag
     4441 gtgggaaaga acccttttgt ctttgtgagg ctgctgagtt cggagagcag ttctcatgcc
     4501 ccttctttga taagcccatc acgggtgctt tctgtatagt aggatgcagg gagcccaagg
     4561 gctccccgag ctcctcagag gacgggctgc tgtggcattt cagatacttg aagtcgaatg
     4621 ctcagtcctg cagccaactc cactggctgc cctgttcagt gatgtctggg gctcatttct
     4681 gtacagccca caagggtttt gtgtgatgcc agatccggtt ttaagtaaca actcaggccc
     4741 agcacatgtc ctccttgcct ggtcatgtgc cctttttatt cacttgtata ctgattactt
     4801 tagagggttc acctttcaaa gagggaacca tattgggaca aaagagtttt tgaaatcttt
     4861 ttgatctgtg accattgagg aaaaggaaag aaaggaagaa acagcacaaa actattactt
     4921 gcttccaggt ctgaggttgg tgggactttt tctgcagctt taatccttaa cctgtcttga
     4981 cctttaaaat gcagagctga agtgatttac tttcctttaa aagaagcaag ccacttccaa
     5041 aaccgtaaac tcctgtcatt tgaacttgca caggaaagct aggtgtagtg gtgctcgcct
     5101 ttgatcacag ctctccagaa gcaggaggat ctctgtgagt ttgaggctag cctggtctac
     5161 acagtgagtt ccgggacagc cagggctaag tagagaaacc ctgtctcaaa acaaacaaaa
     5221 caaaaacaaa acaaaacaaa atcgccctgc aacaaaaatt aacttgcaaa aggaaacctg
     5281 tccttggttt tggttttgta cctgtgtttt gttgtgtgga attttttttt ttaagcgtct
     5341 ctgctcattg tcctaccaga aaatcccaga gagctcactg cttgctactc cataaatatt
     5401 gtacccaagg aaagggatca tggagtctgt ggatatgagc ttctttgtag cctttaaaag
     5461 agggagtctc tctcagtgaa tatagctttc aaagacaagg agaaagaact ccgggtcgcc
     5521 cagctctgct tcccctgggc ttttcctcag ctagtgcgga cacatgtggc aaaggaggct
     5581 ggctctgcag ccaagaggga agatggatca gaatgctgct gtggggcgcg aaggcaggtg
     5641 gatgagtagc caggcacttc ctggctaaca gtagcaactg agtatagaaa agttcatctt
     5701 cctccatgga gggccgaggc tgatgcctgt gcgttgtgtc caggagacat tctagaacag
     5761 ctctgtgact tgtgatactt tacagaacat gctacctcaa agtgctgtga caaaccatgc
     5821 ggactgtagt gctcacagga cgggcacgtg tctcaatcaa agtttggtta tttgtttatc
     5881 tgggtttttt agatgtgggt gtttttgttt gtttcttttt tctttctttc gtcctgtttt
     5941 tttttttttt ttttgtacag tgagatctta cctattaaat atatttagtg ggtcatggtt
     6001 cctgaaggtg attgaattga ttgtgtgtac gaatatgtgt gtgtgttttg acttaaatat
     6061 atttggtgtg tgctgttttg gagttccttt tatatatata tatatatata tatatttgga
     6121 gaatggatgc aagtttcaaa gcactcagtt tttctgattt tatgtactaa taattagggc
     6181 ctaagttaaa taaataaaaa tgtgtgtgca tgtaa
//
LOCUS       NM_001438053            2007 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            2, mRNA.
ACCESSION   NM_001438053 XM_006231494
VERSION     NM_001438053.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2007)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 2007)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 2007)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 2007)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 2007)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2007)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2007)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231494.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166757.1, SRR22582416.1262732.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000001.1  254838799-254839081 c
            284-386             JAXUCZ010000001.1  254829899-254830001 c
            387-431             JAXUCZ010000001.1  254829728-254829772 c
            432-507             JAXUCZ010000001.1  254829533-254829608 c
            508-610             JAXUCZ010000001.1  254829330-254829432 c
            611-783             JAXUCZ010000001.1  254829031-254829203 c
            784-906             JAXUCZ010000001.1  254828414-254828536 c
            907-990             JAXUCZ010000001.1  254828151-254828234 c
            991-1114            JAXUCZ010000001.1  254827934-254828057 c
            1115-1257           JAXUCZ010000001.1  254827580-254827722 c
            1258-2007           JAXUCZ010000001.1  254826138-254826887 c
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2007
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     exon            1..283
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1488
                     /gene="Ldb1"
                     /note="isoform 2 is encoded by transcript variant 2; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 2"
                     /protein_id="NP_001424982.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQD
                     VMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKP
                     PSSQESKSENPTSQASQ"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    1258..1344
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     misc_feature    1258..1344
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     exon            284..386
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..431
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..610
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..783
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..906
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..990
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1114
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1257
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..2007
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacactccg gggacgcaca cccgcgcgta cacacgcaga ggcagctcgc cttcctgcct
       61 ggcttccttc ctgtttgctc cgcgcctgac aggcccctcg ctgcaggcag gggcggcccg
      121 caccgggcaa aggccgggcc gggccggcgg cgcgggcaac gggggccgcg ggcggcggca
      181 gcggctcatg cccagcctgt ccctgcgagg ggcgggcatc gtgactcggc tgggccccca
      241 gcagcgggcg atgtgaagat gtcagtgggc tgtgcctgtc ctggttgttc ctcaaagtca
      301 ttcaagctgt actccccgaa ggagcccccg aacggcaacg ccttccctcc cttccatccc
      361 ggcaccatgc tggatcggga tgtgggccca actcccatgt acccacctac atacctggag
      421 cctgggatag ggaggcacac gccatatggt aaccagacag actatagaat atttgaactt
      481 aacaaacgac tacagaactg gacagaggag tgtgacaatc tctggtggga cgctttcacg
      541 accgagttct tcgaggatga tgctatgctg accatcactt tctgcctgga ggatggacca
      601 aagagatata ccattggccg gaccctgata ccacgctact tccgaagcat tttcgagggg
      661 ggtgctacgg agctgtatta cgtacttaag caccccaagg aggcattcca cagcaacttc
      721 gtgtccctcg actgtgacca gggcagcatg gtgacccagc atggcaaacc catgtttacc
      781 caggtgtgtg tggaaggccg gttgtacctg gagttcatgt ttgacgacat gatgcggata
      841 aagacatggc acttcagtat ccggcagcac agagagctca tccccaggag tatcctggcc
      901 atgcacgccc aggaccccca gatgttggat cagctctcca aaaacattac ccggtgtggg
      961 ttgtccaatt ccactctcaa ctacctccga ctctgtgtga tactggagcc catgcaggaa
     1021 ctcatgtccc gtcacaagac ctacagcctc agcccccgag actgcctcaa gacctgcctt
     1081 ttccagaagt ggcagcggat ggtagcacct cccgcggagc ctgcacgaca gcagcccagc
     1141 aaacggagga aacggaagat gtcagggggt agcaccatga gctcgggggg cggcaacacc
     1201 aacaacagca acagcaagaa gaagagccca gccagcacct tcgctctctc cagccaggat
     1261 gtgatggtgg tgggggagcc caccctgatg ggcggggagt tcggggacga ggacgagagg
     1321 ctcatcactc ggctggagaa cacccagttt gacgcggcca acggcattga cgacgaggac
     1381 agctttaaca actcccctgc actgggcgcc aacagcccct ggaacagcaa gcctccgtcc
     1441 agccaagaaa gcaaatcgga gaaccccacg tcacaggctt cccagtaaag gccctaccac
     1501 ggccacccag gtctctgcct gctacccctc acagctccag ggagcagaag ccagaacgaa
     1561 gagactgggc gtctgaaatg ggcaacctcc atctacccac ttcagggagg gactggactc
     1621 gctgggggca ggtgccaaga tttgcccccg agttgccctg ggctgggcct ggcccctgca
     1681 gagccttttg ggggaagggg gtactcatgt ggatgcctat atggaccctg ggcttctgag
     1741 aaatgtcctg accctcctct ccccagggca tttgtcccca ttcgtacccc aggttctggg
     1801 taccccatct tcctgattta tccctttgag cctggggttt atacccacag cccttagggg
     1861 ctaaatgttg gggccttggt tgaatgccct ttcccctagg cggctgtcaa cagagggtaa
     1921 aattctgggc tcctcccttt tgccacttac ccagctccaa gtttttaaaa aaaaataata
     1981 ttattaaaaa tgtaaattaa aaaaaaa
//
LOCUS       NM_001127552            2898 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 7, mRNA.
ACCESSION   NM_001127552 XM_001079562 XM_341841
VERSION     NM_001127552.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2898)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2898)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2898)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2898)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2898)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2898)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced NM_001127552.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166537.1, SRR21887623.1153182.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-856             JAXUCZ010000001.1  96116217-96116393   c
            857-922             JAXUCZ010000001.1  96115848-96115913   c
            923-1105            JAXUCZ010000001.1  96111458-96111640   c
            1106-1277           JAXUCZ010000001.1  96111181-96111352   c
            1278-1509           JAXUCZ010000001.1  96109086-96109317   c
            1510-2898           JAXUCZ010000001.1  96101906-96103294   c
FEATURES             Location/Qualifiers
     source          1..2898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2898
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1548
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 7 is encoded by transcript variant 7; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 7"
                     /protein_id="NP_001121024.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNG
                     EDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLN
                     AETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREF
                     ADFEYRTTKLLHSLQTSL"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            857..922
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1105
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1277
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1509
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2898
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagg tcgatcaagc cctcagttag accctttgag aaaaagtcca
      721 accatggaac aagcagtgca gaccgcctcg gcccacttac ctgctccagc acctgttggg
      781 agaaggagcc ctgtacccgc caggcctttg ccacctacca gccagaaagc aatagacaac
      841 caagagcaca ggcgagctga agttcacaaa gtcccaaggc cagaaaatga gcaactcaga
      901 aatgacagca agaggcaagt agttcctgga gttccttctg ctccaagaag aggacgtggg
      961 ggtcatcgag gtggcagggg aagatttggt attcgtcgag atggtccaat gaaatttgag
     1021 aaagactttg actttgaaag tgcaaatgca caatttaaca aggaggaaat cgacagagag
     1081 tttcataata aacttaaatt aaaagaagat aaacttgaga aacaagagaa acctgtaaac
     1141 ggtgaagaca aaggagactc gggagttgat acccagaaca gcgaggggaa tgctgatgag
     1201 gaagatcccc ttgggcccaa ctgctactac gacaaaacca aatccttctt cgacaacatc
     1261 tcttgtgatg ataatagaga aaggagacca acttgggctg aagaaagaag gttaaatgct
     1321 gaaacttttg gaatcccact tcgtccaaat cgtggccgtg ggggttaccg aggcagagga
     1381 ggccttggct tccgtggtgg cagaggacgt ggtagtggcc gaggaggaac cttcactgcc
     1441 cctcgagggt ttcgtgctgg attcagaggc gctcgtgggg gtagggagtt tgcagatttt
     1501 gaatatagga caacaaagtt gctgcatagt ctacaaacaa gtctctgaac ataggtgact
     1561 cctagctctt catggtcctg gaaagtggtt cggtctttgt gaagaatgaa gaagtgaagt
     1621 tgctgtctgt ctgtcaccag cactgggttt tgtctgtttt ctgcttcacg tcaaagctat
     1681 actgcagttg ctttggggca ggaaggctcg tcttaaaaca caagcataag tgtgtgtgga
     1741 gtagcaggtt atgattcctt gcttagagtt gaactaaagc cagctaaatg gaattgctaa
     1801 gtgttttttc ttcaatgaaa ggatttttct tatcactaat taattgtatt cggcaattac
     1861 tttgagttgc ctgcagatag gccgtgatac tgtgttttga gccacagaaa gttttgtgtg
     1921 tgtgcgcgcg cgcgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacgtg tgtgtcccat
     1981 aatatgaggt agcttatttc gacacttaat tagggtgctg gatggtagag aattttgtca
     2041 gtcaactatg tacacacagg taaatactgt ttcttaggca aaggtaactt ttttatatag
     2101 ttgtaaaatt ccattatatt ccattgccaa agaaacatta agaactttgt atagctgtat
     2161 aaaaagcaac taatttttta aagaataaac gttttaaagt cagcaaacat acgtgtcctt
     2221 gcagaagtca gtgtgctgag gagcagggat atgggtgggt ctttttcccc ttgctttcca
     2281 ggcttaaggt tttttatttc ctttgtaatg tttggaacac aaatgaagat ttgataactt
     2341 tattccatta tctaaaaagc ataaattatt catgcatagt gtatggactt cgttttgtag
     2401 caaatcacag gatttgttca aataacagat attttaagtg tgtgaatgta aataatcata
     2461 gatgagaatg taccttgctg tattttcaaa taagtaacct tctccttttt aagacattaa
     2521 gactcgttga tctatcagtt gacccgctcc tcctgctatg cctggaattc tgttgtggta
     2581 atgctgactc ctgttttcca tcaaaaagat ggagttttca gaatcatctg gcacctgtaa
     2641 aacatcacta acatagtgtg taggcctgcg gcctaccgat gactctgtac acgtttgttg
     2701 ctaactgtaa attactaata aatctttttt gatatttaag ctatagtgga aaaagatctg
     2761 gccactttgt gtttttaata aaggccatgg aataaaggga tccaaagatt tcaatatttt
     2821 taactatatt ggcttttgtt aactttctca ataaaacatt gagtagtgat agacgtgtgg
     2881 gaaactgcac tgtaggag
//
LOCUS       NM_001438088            2285 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 5, mRNA.
ACCESSION   NM_001438088
VERSION     NM_001438088.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2285)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2285)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2285)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2285)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.1195.1,
                                           SRR26643298.1771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000001.1  88052403-88052762   c
            361-535             JAXUCZ010000001.1  88045950-88046124   c
            536-701             JAXUCZ010000001.1  88045709-88045874   c
            702-786             JAXUCZ010000001.1  88043417-88043501   c
            787-824             JAXUCZ010000001.1  88042666-88042703   c
            825-1066            JAXUCZ010000001.1  88042312-88042553   c
            1067-1167           JAXUCZ010000001.1  88042068-88042168   c
            1168-1219           JAXUCZ010000001.1  88040749-88040800   c
            1220-1256           JAXUCZ010000001.1  88040554-88040590   c
            1257-1302           JAXUCZ010000001.1  88040283-88040328   c
            1303-1393           JAXUCZ010000001.1  88040092-88040182   c
            1394-1451           JAXUCZ010000001.1  88038970-88039027   c
            1452-2285           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2285
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..360
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     exon            361..535
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1489
                     /gene="Vasp"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 5"
                     /protein_id="NP_001425017.1"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKLQPD
                     QQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQFAIGMANALEALEG
                     GGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPPAPPAGGPPPPPGPP
                     PPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGSGAPGLAAAIAGAKL
                     RKVSKQEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQVGEKPPKDESASQE
                     ESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSSSDDSDLERVKQEL
                     VEEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    398..697
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    398..697
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(404..406,425..427,569..571,575..577,593..595,
                     599..601,605..607)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(404..406,425..427,569..571,575..577,593..595,
                     599..601,605..607)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    1001..1081
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    1001..1081
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(1022..1027,1031..1036,1043..1045,1049..1063)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(1022..1027,1031..1036,1043..1045,1049..1063)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    1049..1060
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1049..1060
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1376..1474
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1376..1474
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            536..701
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            702..786
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            787..824
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1066
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1167
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1219
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1256
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1302
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1393
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1451
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..2285
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccctccag ccgggtccca gccgggaccc ggcttcgcgc cccgcctttg tccccctccc
       61 cccagctcgt tcggggctgg atttagggga cacagcgctt tgagcgtccc agatctgggc
      121 cgatgtctct tggagcgatc tctaaatatc gacaccccgt ttctccacac tactccctaa
      181 aggcttgggg cggtgccggc tgaggttctc ttgatggctt tcaggtttag gggcgctctc
      241 gggactcaga atttgaagac ttttgggggg agcacctccg agttcgcaga taagtagaac
      301 gtcgcaggga tgaactggta taagtgggct cagagttact gcccccaaac tcaaaaccag
      361 caacgagacg gtcatttgtt ccagccgggc tactgtgatg ctttacgatg acagcaacaa
      421 acgatggctt cctgctggca ccggtcccca ggcctttagc cgcgtccaga tctaccacaa
      481 ccccactgct aactctttcc gagttgttgg ccgcaagctg cagcctgacc agcaggtggt
      541 tatcaactgt gccatcattc gaggtgtcaa gtacaatcag gccactccca tattccacca
      601 gtggcgtgat gcccgccagg tctggggcct caacttcggc agcaaggagg acgctgcgca
      661 gtttgcgatc ggcatggcca atgccctgga ggccttggaa ggaggtgggc ctccccctgc
      721 cccagcaccc cctgcctggt ctacccagaa tggcccctcc ccagaggagc tggaacaaca
      781 gaaaaggcag cctgaacatt tggagcgccg ggtctccaat gcaggaggcc cacctgctcc
      841 cccagctggg ggcccacctc cacctccagg acctccccct cctccgggtc cccccccacc
      901 cccaggtctg cccccctcag gggtatctgg ggcaggtcat ggaacaggtg tagccccacc
      961 ccctgcaccc ccactcccta cagcacaggg ccccagtagt gggggttccg gggccccagg
     1021 cctggccgct gccattgctg gagccaaact caggaaagtg agcaagcagg aggaggcctc
     1081 tggggggccc ctggccccca aagctgagaa tagtcgaggc actggtgggg ggcttatgga
     1141 agagatgaac gccatgctgg cccggagaag gaaagccaca caggttgggg agaagccccc
     1201 caaagacgag tcagccagtc aggaggagtc agaggcccga atccctgccc aaagtgaacc
     1261 tgtgcgaaga ccctgggaga agaacagcac aaccttgcca aggatgaagt catcctcttc
     1321 tgtgactacc tccgaggccc acccctctgt gcccagctcc agtgatgact ccgacttgga
     1381 gagggtgaag caggagcttg tggaagaggt gcggaaggag ctacagaaaa tgaaagagga
     1441 aataatcgaa gtctttgtcc aggagctgag gaagcggggt tctccttgac tacagggacc
     1501 cagaagaccc atttcttctt tttgtacttc ctgcctggca cctgctttcc ctgcctcaac
     1561 ttgaccaaga gttacacaag aatgcgttct cccctaccag ctcccacttg gaagattcca
     1621 caggggtgtg gcttcctggt gccgtggtca cacccacgct ggctgctgat tggataagga
     1681 ggtcccaccc ctttgttccc tttggtcctt ccccttcacc atccccttgg agctggttcc
     1741 tctgctgggg atgtaagagt aaccccacag taagggaagg aaggagggga tctcaccttc
     1801 tcttgttctg gattcacttt aacgctttaa tgccttggaa tttttttttt taagaaaaag
     1861 tatatatata tatttgggtt ttgtgggggg aagggaaatt ttttgttctc tttggttttg
     1921 ataaaatggg gtgtgggagt ttttaaatgc tataccccaa gctttgtccc atcagaggca
     1981 gctatgtaag aggaggggta tcccaccaag tagggggcat ttcccccacc cctgggatac
     2041 ctccccattt gccttggctc ctctctcttt tctataagga attaagattc tttaactttt
     2101 ttggaacctc agttttgtgg ttttttttat ttgggttagg atttcagggt ccagaccatt
     2161 tttgccctcc aggaagacga agtgaggggg aggagaagag gaaaaatagg tcctccgact
     2221 tctacaccat agcttcttgg acacgggccc tcgctgaata aatctgcagt ttttataaat
     2281 gcaaa
//
LOCUS       NM_001438115            2956 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 3, mRNA.
ACCESSION   NM_001438115 XM_039082050
VERSION     NM_001438115.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2956)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2956)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2956)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2956)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2956)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2956)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039082050.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1984193.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-856             JAXUCZ010000001.1  96116217-96116393   c
            857-922             JAXUCZ010000001.1  96115848-96115913   c
            923-1105            JAXUCZ010000001.1  96111458-96111640   c
            1106-1274           JAXUCZ010000001.1  96111181-96111349   c
            1275-1506           JAXUCZ010000001.1  96109086-96109317   c
            1507-1563           JAXUCZ010000001.1  96105606-96105662   c
            1564-2956           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2956
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1530
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 3 is encoded by transcript variant 3; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 3"
                     /protein_id="NP_001425044.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKDKLEKQEKPVNGE
                     DKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNA
                     ETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFA
                     DFEYRKTTAFGP"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    1009..1338
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    1009..1338
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            857..922
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1105
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1274
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1506
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1563
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2956
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagg tcgatcaagc cctcagttag accctttgag aaaaagtcca
      721 accatggaac aagcagtgca gaccgcctcg gcccacttac ctgctccagc acctgttggg
      781 agaaggagcc ctgtacccgc caggcctttg ccacctacca gccagaaagc aatagacaac
      841 caagagcaca ggcgagctga agttcacaaa gtcccaaggc cagaaaatga gcaactcaga
      901 aatgacagca agaggcaagt agttcctgga gttccttctg ctccaagaag aggacgtggg
      961 ggtcatcgag gtggcagggg aagatttggt attcgtcgag atggtccaat gaaatttgag
     1021 aaagactttg actttgaaag tgcaaatgca caatttaaca aggaggaaat cgacagagag
     1081 tttcataata aacttaaatt aaaagataaa cttgagaaac aagagaaacc tgtaaacggt
     1141 gaagacaaag gagactcggg agttgatacc cagaacagcg aggggaatgc tgatgaggaa
     1201 gatccccttg ggcccaactg ctactacgac aaaaccaaat ccttcttcga caacatctct
     1261 tgtgatgata atagagaaag gagaccaact tgggctgaag aaagaaggtt aaatgctgaa
     1321 acttttggaa tcccacttcg tccaaatcgt ggccgtgggg gttaccgagg cagaggaggc
     1381 cttggcttcc gtggtggcag aggacgtggt agtggccgag gaggaacctt cactgcccct
     1441 cgagggtttc gtgctggatt cagaggcgct cgtgggggta gggagtttgc agattttgaa
     1501 tataggaaaa ccacggcttt tggaccctaa aaggtctgga ttggtcatac tgctttctga
     1561 aagaaagaca acaaagttgc tgcatagtct acaaacaagt ctctgaacat aggtgactcc
     1621 tagctcttca tggtcctgga aagtggttcg gtctttgtga agaatgaaga agtgaagttg
     1681 ctgtctgtct gtcaccagca ctgggttttg tctgttttct gcttcacgtc aaagctatac
     1741 tgcagttgct ttggggcagg aaggctcgtc ttaaaacaca agcataagtg tgtgtggagt
     1801 agcaggttat gattccttgc ttagagttga actaaagcca gctaaatgga attgctaagt
     1861 gttttttctt caatgaaagg atttttctta tcactaatta attgtattcg gcaattactt
     1921 tgagttgcct gcagataggc cgtgatactg tgttttgagc cacagaaagt tttgtgtgtg
     1981 tgcgcgcgcg cgcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtacgtgtg tgtcccataa
     2041 tatgaggtag cttatttcga cacttaatta gggtgctgga tggtagagaa ttttgtcagt
     2101 caactatgta cacacaggta aatactgttt cttaggcaaa ggtaactttt ttatatagtt
     2161 gtaaaattcc attatattcc attgccaaag aaacattaag aactttgtat agctgtataa
     2221 aaagcaacta attttttaaa gaataaacgt tttaaagtca gcaaacatac gtgtccttgc
     2281 agaagtcagt gtgctgagga gcagggatat gggtgggtct ttttcccctt gctttccagg
     2341 cttaaggttt tttatttcct ttgtaatgtt tggaacacaa atgaagattt gataacttta
     2401 ttccattatc taaaaagcat aaattattca tgcatagtgt atggacttcg ttttgtagca
     2461 aatcacagga tttgttcaaa taacagatat tttaagtgtg tgaatgtaaa taatcataga
     2521 tgagaatgta ccttgctgta ttttcaaata agtaaccttc tcctttttaa gacattaaga
     2581 ctcgttgatc tatcagttga cccgctcctc ctgctatgcc tggaattctg ttgtggtaat
     2641 gctgactcct gttttccatc aaaaagatgg agttttcaga atcatctggc acctgtaaaa
     2701 catcactaac atagtgtgta ggcctgcggc ctaccgatga ctctgtacac gtttgttgct
     2761 aactgtaaat tactaataaa tcttttttga tatttaagct atagtggaaa aagatctggc
     2821 cactttgtgt ttttaataaa ggccatggaa taaagggatc caaagatttc aatattttta
     2881 actatattgg cttttgttaa ctttctcaat aaaacattga gtagtgatag acgtgtggga
     2941 aactgcactg taggag
//
LOCUS       NM_001438033            6561 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2),
            transcript variant 3, mRNA.
ACCESSION   NM_001438033 XM_039079984
VERSION     NM_001438033.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6561)
  AUTHORS   Wang,T., Chen,S., Wang,X., Huang,Y., Qiu,J., Fei,Y., Chaulagain,A.,
            Chen,Y., Wang,Y., Lin,L., Yan,B., Wang,Y., Wang,W., Zhao,W. and
            Zhong,Z.
  TITLE     Aberrant PD-1 ligand expression contributes to the myocardial
            inflammatory injury caused by Coxsackievirus B infection
  JOURNAL   Antiviral Res 166, 1-10 (2019)
   PUBMED   30904424
REFERENCE   2  (bases 1 to 6561)
  AUTHORS   He,H., Zhou,Y., Zhou,Y., Zhuang,J., He,X., Wang,S. and Lin,W.
  TITLE     Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation
            through Upregulation of Programmed Cell Death Protein 1 in a Rat
            Spinal Cord Injury Model
  JOURNAL   J Neurotrauma 35 (21), 2591-2603 (2018)
   PUBMED   29665726
REFERENCE   3  (bases 1 to 6561)
  AUTHORS   Wilson,J.K., Zhao,Y., Singer,M., Spencer,J. and Shankar-Hari,M.
  TITLE     Lymphocyte subset expression and serum concentrations of PD-1/PD-L1
            in sepsis - pilot study
  JOURNAL   Crit Care 22 (1), 95 (2018)
   PUBMED   29661225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6561)
  AUTHORS   Singh,A., Mohan,A., Dey,A.B. and Mitra,D.K.
  TITLE     Inhibiting the programmed death 1 pathway rescues Mycobacterium
            tuberculosis-specific interferon gamma-producing T cells from
            apoptosis in patients with pulmonary tuberculosis
  JOURNAL   J Infect Dis 208 (4), 603-615 (2013)
   PUBMED   23661793
REFERENCE   5  (bases 1 to 6561)
  AUTHORS   Cao,J., Liu,F.X. and Yu,M.X.
  TITLE     Expression of programmed death 1 and its ligands in the liver of
            autoimmune hepatitis C57BL/6 mice
  JOURNAL   Chin Med J (Engl) 122 (16), 1941-1946 (2009)
   PUBMED   19781375
REFERENCE   6  (bases 1 to 6561)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
REFERENCE   7  (bases 1 to 6561)
  AUTHORS   Liang,S.C., Greenwald,R.J., Latchman,Y.E., Rosas,L., Satoskar,A.,
            Freeman,G.J. and Sharpe,A.H.
  TITLE     PD-L1 and PD-L2 have distinct roles in regulating host immunity to
            cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 36 (1), 58-64 (2006)
   PUBMED   16358363
REFERENCE   8  (bases 1 to 6561)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   9  (bases 1 to 6561)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 6561)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039079984.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.4213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000001.1  236591183-236591523
            342-611             JAXUCZ010000001.1  236617238-236617507
            612-747             JAXUCZ010000001.1  236620844-236620979
            748-6561            JAXUCZ010000001.1  236636875-236642688
FEATURES             Location/Qualifiers
     source          1..6561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..6561
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
     exon            1..341
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    209..211
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="upstream in-frame stop codon"
     CDS             287..787
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; PD-1 ligand 2; PDCD1 ligand 2; programmed death
                     ligand 2"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 isoform 2
                     precursor"
                     /protein_id="NP_001424962.1"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
                     /translation="MLLLLLILNLSSQLHHIAASYVRIDTGILEVPGTGEVQLICQAR
                     GYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPNRNFSCMFWNAHMKELTS
                     AIIDPLSWMEPKVPRTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKRSEPAVL
                     GVGKIQ"
     sig_peptide     287..343
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    359..604
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    359..604
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    395..409
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    395..409
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    434..448
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    434..448
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    512..526
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    512..526
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    545..562
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    545..562
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    590..601
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    590..601
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            342..611
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..747
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..6561
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgttcatc ctgctctcca gaaaaggccc tgcgagaagc aaaaagagca gctcatttga
       61 attcagaaag agtgccttct tcctccttgc tgtgcataag ctcttctcca gaaaaggaac
      121 ccacgggctc tcttcttgtc tctgctactc cattgtcacc tgcatctccc acaagatttg
      181 attctgagtc attaccatgc tcttgggatg agttaaactg gcggagactg agaaagtgca
      241 cggagcccgg agactctcaa ttgtctgttt cagattgata cagaccatgc tgctcctgct
      301 gctgatactg aacctgagct cgcaacttca tcacatagca gcttcttacg tgaggataga
      361 cactgggatc ctagaggttc cagggacagg ggaggtgcag ctcatctgcc aggctagagg
      421 ttacccccta gcagaagtgt cctggcaaaa tgtcagtgtt cctgccaaca ccagccacat
      481 caggacccct gaaggcctct accaggtcac cagtgttctg cgcctgaagc ctcagcctaa
      541 cagaaacttc agctgcatgt tctggaatgc tcacatgaag gagcttactt cagccatcat
      601 tgaccctctg agttggatgg aacccaaagt ccccagaaca cggtcacttc atgctttcat
      661 cccggcctgc actgtcgctc tcatcttcct agccacagtg atagcccaga gaaagaggct
      721 ctggggaaag ctgtattcta gaaaaagatc tgagcctgcg gtcttgggag ttgggaagat
      781 ccaataggaa atcctcaaga ggcttctgga ctcaaagtga gaatctagca gagccgccat
      841 ttgcactttt cgaatgctga tcaggagctt gcaggactgc caagactgcc ttcccttcct
      901 ctcaagactc tctctgaaca aaaacaacca caatggcacc ctagagtcct ccctcccccc
      961 ccccctgggg atcctggacc ccagtgaagc ccttcctggt ttccagggtg aaaacaaaag
     1021 gaattgttct tcctcctccc cctgcgttcc acggggagac aaggaaattc ccagttacta
     1081 aaatagattg tgttgataat agagtttttt aatatctgtc atttcctctg gggatttgga
     1141 agtttcagaa agggttttta gtaaacaaag tcataactga tgtgtttcac tgcatcctag
     1201 aatcctggca gcctctgaag ttctgattat caggaagcat ttgagtacac aactgtggaa
     1261 tttgtttcta cttttctttt tttaaagctg agtcacacaa ggcatttgtt gtaacctgtg
     1321 atgtcactgt ttattgatct cttctctttc aactacattt tttaagacga aacggtgtag
     1381 ggttttgttg ttttgttggt ggtggtagtg tttctcagtg gtatcacttt aagaaaaaaa
     1441 aaatcatcat gccagttctt tctttagacg gttcagatga ggagctgtaa tcaccagtcc
     1501 cccgagctaa gccttcttcc ctagccttcc gtgtgatttt acgttgaacg tttgtgttgc
     1561 tctgtttcta taactgtaat gtggtgatgt cattgtcggg gcatttgatg atgagcattc
     1621 tggaagtcct tttgtaagag aaaaaccctc tgagccctac gttcagcccc actcacagag
     1681 acacagagac aggatcaatg caataagcaa gaggtttcat gatccagtgc actggggtgg
     1741 ccctgtactc agggcagagg cgacctcaaa gaacaaaggc ccacgccctt tatactgttt
     1801 ttcagggtat aggctttagg ttacagcatg agttgattat ttctcattgg tgggccctat
     1861 taccttttga attcattggt ggctgcctat cgtcctttga agtcattgga ggcccttggt
     1921 ggggaagtat atttggcatg cagtgggggt gatgaaggac tcctgctaag ggcagctacc
     1981 tcatttcctg gaacagggtg ttatcctaaa ttccacctgg tgtttggcta aggcagcctt
     2041 tgtctttaag tttgaatctt acactttcag gttagtgttt gcgggggaga gagctcagaa
     2101 tacggaatgg tgctaacttg aagctggagg catggaatta actaaccttt gggctaccca
     2161 aatgtgcaca ttagctacca tgacatctgt aggctagcaa gctctttacc tagtgtttag
     2221 actgagcaga atttggagtc aatgagccca aaagggtgca aaattaagat ttgaattatg
     2281 catcttattt tatcaccatc tgctcacgcg aaacagagaa tacctttgaa gcacaaaaat
     2341 gtgatcgttt atttgaaacc tctgaggtac atacactcag atgccctttg cagcaaggtg
     2401 tctctctaag attcctgtag ggaaagcagc cctactcagt accagacagc agccctactc
     2461 agtaccagat agcaggacag agagaaaagt ctatgctaga cctcccctct caggtgtgtg
     2521 attggcaggc caaaccccga ttgccaacca gggtttgtct gctttattag gaatccagtg
     2581 gcactatgga tgctgacaaa atgccaccat ctcagccctc actgggctgt tttctaggat
     2641 atcaatagag aaagggccaa ctagatccag tatcctaaaa tcctgagaga agaatataag
     2701 ttagcgtgtc tcactgtgat aagtgtccct ctacatgatt gatcacatta atatctaaca
     2761 attaccaaat acttactata tgcccaattc tgttgagcat ttcatacaca ccattggatg
     2821 gaattctctc aaaatcctca gaaaagggaa ttattaatac ctccataggc aaggagcccg
     2881 gagcccagcg aggttggttg ggcagtctgg ttaaggatgt ctgctttgtt tagaaggaag
     2941 tgaaaaagaa catcaaactc atatttatta tagccctggt tattaatgta cctggttacc
     3001 tgctggatgg gacatcaagg tggacttttg gcacttgcat atgcccggtg ttatttcggc
     3061 tagtcacgga ttaatttcac actcactgtt tcccagacat gtgtagggga agtccaggtt
     3121 cggaggggcc taagattcgt actctagctt agttatctaa gtctttaaat ccaccagctg
     3181 acctccccgc acattaattt ccctatctaa agagtgagca gtaaccgagt gatacctcct
     3241 cccttccctt atcaggcact gttgtgggta gggtgcaatg aatacttgat aaatatgtgt
     3301 ccgtgtgaat ccccacgtgc cagccgctgt ccccaatgca aaagcagcac agcattcaga
     3361 catctcaggc tgatttatca gcagcggatt tctcctagcc ccatgcctaa agaaacttcc
     3421 agcctagata tgttgtgtag gttttgtgtc ccagaagccc ctacacaggc ctcaacttca
     3481 ctactgggat tgctcaggaa actgtaccca cacagaccac ttttctaaga atttggcaaa
     3541 cacctttgag tttatgctac tgtcattgaa aacgttatcg tggatgtgga gagtgcatgg
     3601 tcagcacagt gccatgggat ttgaagttct tttaaatgtg cttcctgttt caaggtattt
     3661 ggtgagaaga agctgtttca tgacctcttc ttaaaataga tccaggtggt gaggtgcaaa
     3721 cagacagcaa atggtgttca ttttgtaact cacatgacca cctcactgct acctgtcaaa
     3781 gggtacctat cctcttaaca catctgagag tgtttaaaga atgagtctga ggcttagcag
     3841 gtaaaagtgc ttgtcatcac acaagcctga tgaccagagt tcaaacctca gaacccacag
     3901 tggaaggaga agagagaacc cacccctgaa agttgttctc tgacctccac atctgtgcca
     3961 tggtgtacat acacacacac ataatatata cacacatgca cacacataat acatatccac
     4021 acatacatac atacatacac acacatacac acatacatac acacacatac atacacacac
     4081 ataatacata tccacacata catacataca tacatacaca cacatacata cacacacata
     4141 catacacaca taatatatac ccacgcatac atacatacat acacacataa tacatatcca
     4201 tccatccatc catacataca tacatacata catatacaca catacacata catacacaca
     4261 aacatacata tacacacata tacacacata atacataccc acacatatat acatacatac
     4321 atatacacac atacacaaca cattatacat acccccacac acattacata taaaagtcgc
     4381 agtcctgctg catgtctttt attactttta aagtgaatat taaccaagta tttccttgga
     4441 aattctagag cattccttaa ggtcaattct tatccatggg tttctgtttg attggtttag
     4501 ttagttttgt tttgttatgt ggagtggttt tgttatatgg cttccttgag gtggttacag
     4561 gaacgtggat ttgtggggaa ggtgaacttc tcaggagaac cacttacttt ctgaggcgct
     4621 ttatattcac gttgctactg gatgctcttc tagccctggg gttgcttgaa gcttaatttt
     4681 gccaacgtaa caggttaaag caaggacact tttaagtttt ccagttttga tccctggctt
     4741 tgatcctaag ccatcaactc ttcctgtgac ctcggaatct gtgtctaatt tgtgcttccc
     4801 ttccctgctc tgcctctagc taagtgtttt atttactcaa tgatttaatc atttagtttt
     4861 taagctacaa tgtcttcacc tacatatgga catcctaaga ataatactcc tctcactgga
     4921 ctgtcgtatg aaaattatgt atacctgatt gaaaaagctg cccaagaaac atgcatttct
     4981 ttccttaaca aatatgaatt aagagtgaat aattatgtaa attcaagtaa atgattttat
     5041 caattttctt tgaagtttat gttaaggttt acctcataaa ttagaagttt gatactctac
     5101 tatctgattt gtggctttag attcttcact gtcttagact aaaatctttt gaacaattgt
     5161 actttaaaaa ttttttttct tttttctttt tttcggagct ggggaccaaa cccagggctt
     5221 tgcacttgct aggcaagcgc tttaccactg agctaaatcc ccaactcctt aaaattattt
     5281 ttattagttg agatatatct caggaaaatg tactctgatt cacagtaatg ttggagtaga
     5341 gggagaagct agattcttac tcgtagtgag tcatgtctgg tttctagtct gtaattcaag
     5401 tgaggtaggc tttccgaatg acacagacat taattcttag agccacttcc caccagagat
     5461 tcccgtgggt tgaaaacttc tgaatgctag atgatatctt gtcatttcta ttgaaatcgg
     5521 taagtccaac tctgtggtaa tatttcccac cacaccctgc ttacagccct ttgctatgtc
     5581 tcggctcagt gatgcaattc tcagtgcttc agagaagcca cgactccccg atcctcacgg
     5641 actcaagggg caaggcaaga tacacaatta tacatgacca actctccact aaccgcatct
     5701 ccctgagtct ttaaaggcct tcagatgtgt tactccatag accaggtaat gagttagcat
     5761 tactcatgga atgtagccta atcttatgcc catattccaa ccactcgacc gggcacatac
     5821 aacctttccc agctgctaac atatttgttt cacagctttt gccatcttcc aagcaacatc
     5881 cccaaacata aggacctaaa acaattagtg atggtctacg attttctagg ttaacaattt
     5941 ggactgatct aagcaggggc cttacctgga aactagtctg aaaatggcag aagagaagga
     6001 aagccggtat gcacaaggac tttgcaagcc tagggctgca tcacgttttg gtttttatac
     6061 tatttttaat tattttctct ggatggtgct ttgcctgaat gtctgtgcag cacatgtgtt
     6121 cagtgcctca gaggccagaa gaaggcgttg gattccccta gaactggagt tatagatgct
     6181 tgtaagccat attgtagtgg ataggacgtg ggtactgtgg aggagaggta gtgcttttac
     6241 ccactgatct atctccccag ccccagttgt atcacattgt ctaatgtcaa agagagcaca
     6301 tatgtgtagc ctttggtatg taaagagagg acatgaagca tgatacttcg gaggaccaga
     6361 aatgctctaa cagtctaaaa tgttgagtcg aacatatccc acaagtgaca gtcagggtta
     6421 gctgaactgt cccttcagtg gttttctgct ccatccaacg gtagtgtctg ttactcttag
     6481 tcaaatacct ttagaatcaa ccccattttg tgttagtcag tttattctaa tataaattga
     6541 aataaaaatc ttgtgactct c
//
LOCUS       NM_001438106            3706 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 11, mRNA.
ACCESSION   NM_001438106 XM_063266474
VERSION     NM_001438106.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266474.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2177364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-312             JAXUCZ010000001.1  94931937-94932148   c
            313-403             JAXUCZ010000001.1  94931143-94931233   c
            404-571             JAXUCZ010000001.1  94930658-94930825   c
            572-699             JAXUCZ010000001.1  94928181-94928308   c
            700-800             JAXUCZ010000001.1  94928000-94928100   c
            801-883             JAXUCZ010000001.1  94926045-94926127   c
            884-1038            JAXUCZ010000001.1  94925808-94925962   c
            1039-1217           JAXUCZ010000001.1  94923695-94923873   c
            1218-2133           JAXUCZ010000001.1  94922695-94923610   c
            2134-3706           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3706
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            101..312
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    282..284
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            313..403
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..2237
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 3 is encoded by transcript variant 11;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 3"
                     /protein_id="NP_001425035.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEGMWMPNYPSSWTTLKTQDFHLLQPGHLP
                     VPQECG"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            404..571
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            572..699
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            700..800
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            801..883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1038
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1217
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2133
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..3706
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tgcaaagaag actcaatagt
      121 gtggagaagt ctgtttcctg acattctgat tctgttagcc tggagtggga accgggaaga
      181 gcctacgggt gtgcttgggt ataccaaccc actctggcac atcaagtcac tgcaggacta
      241 ggccagtcct ctcccactga ggccaggcaa ggcagcccag ttaaggaaac gggatccaca
      301 gacaggcagc agtcagtttt cacctcccaa gacagccctt ggaaatgttc cccaaggtgg
      361 acaacccttt agaccatcaa gaagccagaa ctggagccac aaggtctcaa aagccacaag
      421 ctcccaaggc cacagcagcc aattctgctg agctgtctga ggagtcctgg ccatccagtt
      481 cagggaccgc ttccccaccc agtaccactg agggacagag tacctctcca cccctcacct
      541 taattgacaa cgaggactca gtggtggcca agtacataaa ccggttccgc aaagctcagc
      601 ccacgagccg agaggaccgc cagcccgtgg gcccaacccc agctgacttt tggtggctac
      661 agcctgcgtc ttcagacctc agcagtcacc ttgcagcagg agctggtgaa cctacaggaa
      721 gatctgccgt gacaggtcca tgtcccaccg ggatgtccag tacgtctctg gcttctgtgc
      781 ctcttcagag agtaaagcag agtctgaact cttggaactc ggctatgctg gagctggaga
      841 ccctgagcct tcaaagccga gcggccaagc tgctggaacg cagcaaggcc tccctctcct
      901 cctcctcctc ctcccccagt cccaacgaag ccagcagctc ctccttcccc atcagctctg
      961 acggcctctc tccctgctct gtgaccttca atccggactc caacaagagt tctagtccca
     1021 aagaacccgt gctgggagca gccccagtgc catcccaggc catccctgca ccccgcccag
     1081 cctctgccca ggcaaccctt aagcctgagg aagacatttt ataccaatgg aggcaacgga
     1141 ggaagcttga gcagtctcta caaggtgcag gtgatggaac ctgggtgttg cctcggacac
     1201 cagccctcac tactcagact cctgtctctg cagtgaatct tggttccaag gggacccaac
     1261 ctaactgtgc tccaccatgg ggcagtgtgg cccagcctcc tcccccacag gcattctata
     1321 tggagaggcc acctctttca gggccctctc cacacatctg ggcccccggc acacacgggg
     1381 ttctctgggc cccacaggcc aatccctgga tacctcttgg gatggttcct accacactgc
     1441 taacctccac ccttgctccc ttggcctcct taccagtacc acctacctcc acttcagctg
     1501 ccacagcccc catctctgct ccccaggtct ccatcccagg gcccccagcc tctgccccac
     1561 ctccctgcac ttctgcccca gcttccaccg tcccactacc tgacaacccc cagggaccaa
     1621 ccacccctga gttgagtagc tctgtccatc ccaagaagct gagccccaag cctcgctgtg
     1681 tgagcgcttc gtctcgtcag gagactactg gaccagacac tgcagctttc gagagtccct
     1741 gttctcagct taggggggct ctgagccagg tagtgacagc tcggctgttc tccgacagcc
     1801 tggaggatat gcctccatct gaagcagatt cccggaaagt caaggccacc tcctctcaag
     1861 ccaaagttcc gccccctcca cctgagtccc ggcgtgggtc caagacagag tcccgcaaaa
     1921 gtaaagtcac cctctcagct gaagctgggg atccacagcc ggctacagcc ccaaaggcat
     1981 ccacactgtc agaggtccaa tcacttgaat tcaagaagtc tacacccaag aagggagctg
     2041 gtgacgcctt gactacggcc ccgcctgcct caagccacgc cccttccgag gacttgctat
     2101 cccaggccgc tagacttctg caggctgcgg aaggaatgtg gatgcccaat tatccctcct
     2161 cttggaccac actgaagacc caggattttc atctcctcca gccaggtcac cttccagttc
     2221 cccaagaatg cggttaagga gggaaggagc ctcccttgag gccagacgac cttgaatcat
     2281 aaacattgtt tttcctgggc tggggaggtg gctcagtggg taaagcactt gcaagtgtga
     2341 agacccgagt ttagatcccc agaacccaca taaaggtaac tgacaggcca gctggtccat
     2401 ggagacaggg tctcaatcaa ggtggaaatc aaagaccaat ctctgaaatt ctctgacttc
     2461 cacacaagag ctgtggggtg tggtgcacat aacacaggca cgcacacaca ggcacacaca
     2521 cacacggacg cacacatgcg ctcgcgcacg cacacacaca cacacacaca catacacagg
     2581 cacacacact aaagttgtcc ccaattaata tttttccagt ttactgttaa tctctaagaa
     2641 atgggttgtt gtagaaaggc tgattgtgct aataaggaaa tgtagctctt ccctaactac
     2701 tgaaacaaag tttcttctct ctagccctcc ttcccacccc ctctctctga tatccctccc
     2761 cctctctctc cccgggagca catggctcta ggtaatgtgg gcacctgact tatgcaactc
     2821 agaagtggag ttggacatct cagatggaga caaaggccct gttatgtggc actaagaaac
     2881 atcagtgttg gacaatacat ctctcatctg agctggcatc ctccctctct gatggccgtc
     2941 tccctccacg ggctcacgat gcctcggttc ccacaggtgc ccagattcct ggtgtttccc
     3001 caagttcgtt ctccttcaca ttcttcaaga ctgtgctctc cctactcagg accaaagtcc
     3061 ttcgacagtt agcctgactc ctccccttcc ccacacatag tcaggcgctg actcggtttg
     3121 ctttatagtt ccccagaatc caactccttt ccgctgccct cgcctcagtc taggcttcct
     3181 cctacctgta cagttgaagg ttcgccatta ctataaacac atctgctccc tctttgatgc
     3241 acttgccacc cagggggaca gcctgtctct tctctttgaa actgagcttt tcaacaaatg
     3301 cacctgaaag cctgaggcct ctgtcagaaa catgggttct gtcctcccgt tctttttctt
     3361 actttctgtg actcagatgc ttttcagagt ctgctatgaa acctgattgc tggacacgga
     3421 aacacacacc tgtaatctca ggagtctgag gccagaggat ctcactctgg ggtcaccctc
     3481 atagtgagtc cctgtgttga aaaaaagagt catggggctg gagagatggc tcagtggtta
     3541 agagcactga ctgctcttcc agaggtcctg agttcaattc ccagcaacca catggtggct
     3601 cacaaccatc tgtaatggga tctgatgccc tcttctggtg tgtctgaaga caactacagt
     3661 gtacttatat ataataaata aataaatctt taaaaaagaa agaaaa
//
LOCUS       NM_001438099            3628 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 5, mRNA.
ACCESSION   NM_001438099 XM_063266459
VERSION     NM_001438099.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266459.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.1404.1,
                                           SRR26643299.1996.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000001.1  94933991-94934157   c
            168-258             JAXUCZ010000001.1  94931143-94931233   c
            259-426             JAXUCZ010000001.1  94930658-94930825   c
            427-554             JAXUCZ010000001.1  94928181-94928308   c
            555-655             JAXUCZ010000001.1  94928000-94928100   c
            656-738             JAXUCZ010000001.1  94926045-94926127   c
            739-893             JAXUCZ010000001.1  94925808-94925962   c
            894-1072            JAXUCZ010000001.1  94923695-94923873   c
            1073-1988           JAXUCZ010000001.1  94922695-94923610   c
            1989-2070           JAXUCZ010000001.1  94922525-94922606   c
            2071-3628           JAXUCZ010000001.1  94920817-94922374   c
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3628
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..167
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    77..79
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            168..258
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2212
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 5;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425028.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <851..1738
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <851..1738
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1958..>2092
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    1958..>2092
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            259..426
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            427..554
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            555..655
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            656..738
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            739..893
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1072
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1988
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2070
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..3628
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaagcctt tttccatttc tagaagggga agctaaagtc taggaggcag acccttatag
       61 gtgtggctaa tcactgtagc agttgggacc ctgggtccga gaagtccacc aaagagttct
      121 cagccctctt aatccatctc cgcccggccc tgaggatgac gcatcagtca gttttcacct
      181 cccaagacag cccttggaaa tgttccccaa ggtggacaac cctttagacc atcaagaagc
      241 cagaactgga gccacaaggt ctcaaaagcc acaagctccc aaggccacag cagccaattc
      301 tgctgagctg tctgaggagt cctggccatc cagttcaggg accgcttccc cacccagtac
      361 cactgaggga cagagtacct ctccacccct caccttaatt gacaacgagg actcagtggt
      421 ggccaagtac ataaaccggt tccgcaaagc tcagcccacg agccgagagg accgccagcc
      481 cgtgggccca accccagctg acttttggtg gctacagcct gcgtcttcag acctcagcag
      541 tcaccttgca gcaggagctg gtgaacctac aggaagatct gccgtgacag gtccatgtcc
      601 caccgggatg tccagtacgt ctctggcttc tgtgcctctt cagagagtaa agcagagtct
      661 gaactcttgg aactcggcta tgctggagct ggagaccctg agccttcaaa gccgagcggc
      721 caagctgctg gaacgcagca aggcctccct ctcctcctcc tcctcctccc ccagtcccaa
      781 cgaagccagc agctcctcct tccccatcag ctctgacggc ctctctccct gctctgtgac
      841 cttcaatccg gactccaaca agagttctag tcccaaagaa cccgtgctgg gagcagcccc
      901 agtgccatcc caggccatcc ctgcaccccg cccagcctct gcccaggcaa cccttaagcc
      961 tgaggaagac attttatacc aatggaggca acggaggaag cttgagcagt ctctacaagg
     1021 tgcaggtgat ggaacctggg tgttgcctcg gacaccagcc ctcactactc agactcctgt
     1081 ctctgcagtg aatcttggtt ccaaggggac ccaacctaac tgtgctccac catggggcag
     1141 tgtggcccag cctcctcccc cacaggcatt ctatatggag aggccacctc tttcagggcc
     1201 ctctccacac atctgggccc ccggcacaca cggggttctc tgggccccac aggccaatcc
     1261 ctggatacct cttgggatgg ttcctaccac actgctaacc tccacccttg ctcccttggc
     1321 ctccttacca gtaccaccta cctccacttc agctgccaca gcccccatct ctgctcccca
     1381 ggtctccatc ccagggcccc cagcctctgc cccacctccc tgcacttctg ccccagcttc
     1441 caccgtccca ctacctgaca acccccaggg accaaccacc cctgagttga gtagctctgt
     1501 ccatcccaag aagctgagcc ccaagcctcg ctgtgtgagc gcttcgtctc gtcaggagac
     1561 tactggacca gacactgcag ctttcgagag tccctgttct cagcttaggg gggctctgag
     1621 ccaggtagtg acagctcggc tgttctccga cagcctggag gatatgcctc catctgaagc
     1681 agattcccgg aaagtcaagg ccacctcctc tcaagccaaa gttccgcccc ctccacctga
     1741 gtcccggcgt gggtccaaga cagagtcccg caaaagtaaa gtcaccctct cagctgaagc
     1801 tggggatcca cagccggcta cagccccaaa ggcatccaca ctgtcagagg tccaatcact
     1861 tgaattcaag aagtctacac ccaagaaggg agctggtgac gccttgacta cggccccgcc
     1921 tgcctcaagc cacgcccctt ccgaggactt gctatcccag gccgctagac ttctgcaggc
     1981 tgcggaagac tctgacggca gcgagtttcc ggaagactct gtgttgcgag tgctaagggc
     2041 tcagagggca gaactaaggc agcagaaaag gaatgtggat gcccaattat ccctcctctt
     2101 ggaccacact gaagacccag gattttcatc tcctccagcc aggtcacctt ccagttcccc
     2161 aagaatgcgg ttaaggaggg aaggagcctc ccttgaggcc agacgacctt gaatcataaa
     2221 cattgttttt cctgggctgg ggaggtggct cagtgggtaa agcacttgca agtgtgaaga
     2281 cccgagttta gatccccaga acccacataa aggtaactga caggccagct ggtccatgga
     2341 gacagggtct caatcaaggt ggaaatcaaa gaccaatctc tgaaattctc tgacttccac
     2401 acaagagctg tggggtgtgg tgcacataac acaggcacgc acacacaggc acacacacac
     2461 acggacgcac acatgcgctc gcgcacgcac acacacacac acacacacat acacaggcac
     2521 acacactaaa gttgtcccca attaatattt ttccagttta ctgttaatct ctaagaaatg
     2581 ggttgttgta gaaaggctga ttgtgctaat aaggaaatgt agctcttccc taactactga
     2641 aacaaagttt cttctctcta gccctccttc ccaccccctc tctctgatat ccctccccct
     2701 ctctctcccc gggagcacat ggctctaggt aatgtgggca cctgacttat gcaactcaga
     2761 agtggagttg gacatctcag atggagacaa aggccctgtt atgtggcact aagaaacatc
     2821 agtgttggac aatacatctc tcatctgagc tggcatcctc cctctctgat ggccgtctcc
     2881 ctccacgggc tcacgatgcc tcggttccca caggtgccca gattcctggt gtttccccaa
     2941 gttcgttctc cttcacattc ttcaagactg tgctctccct actcaggacc aaagtccttc
     3001 gacagttagc ctgactcctc cccttcccca cacatagtca ggcgctgact cggtttgctt
     3061 tatagttccc cagaatccaa ctcctttccg ctgccctcgc ctcagtctag gcttcctcct
     3121 acctgtacag ttgaaggttc gccattacta taaacacatc tgctccctct ttgatgcact
     3181 tgccacccag ggggacagcc tgtctcttct ctttgaaact gagcttttca acaaatgcac
     3241 ctgaaagcct gaggcctctg tcagaaacat gggttctgtc ctcccgttct ttttcttact
     3301 ttctgtgact cagatgcttt tcagagtctg ctatgaaacc tgattgctgg acacggaaac
     3361 acacacctgt aatctcagga gtctgaggcc agaggatctc actctggggt caccctcata
     3421 gtgagtccct gtgttgaaaa aaagagtcat ggggctggag agatggctca gtggttaaga
     3481 gcactgactg ctcttccaga ggtcctgagt tcaattccca gcaaccacat ggtggctcac
     3541 aaccatctgt aatgggatct gatgccctct tctggtgtgt ctgaagacaa ctacagtgta
     3601 cttatatata ataaataaat aaatcttt
//
LOCUS       NM_001438090            2282 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 6, mRNA.
ACCESSION   NM_001438090
VERSION     NM_001438090.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2282)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2282)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2282)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2282)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2282)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2282)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2282)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2282)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2282)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.1300.1,
                                           SRR26643299.1441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000001.1  88052403-88052762   c
            361-535             JAXUCZ010000001.1  88045950-88046124   c
            536-701             JAXUCZ010000001.1  88045709-88045874   c
            702-786             JAXUCZ010000001.1  88043417-88043501   c
            787-824             JAXUCZ010000001.1  88042666-88042703   c
            825-1066            JAXUCZ010000001.1  88042312-88042553   c
            1067-1167           JAXUCZ010000001.1  88042068-88042168   c
            1168-1219           JAXUCZ010000001.1  88040749-88040800   c
            1220-1253           JAXUCZ010000001.1  88040554-88040587   c
            1254-1299           JAXUCZ010000001.1  88040283-88040328   c
            1300-1390           JAXUCZ010000001.1  88040092-88040182   c
            1391-1448           JAXUCZ010000001.1  88038970-88039027   c
            1449-2282           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2282
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..360
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     exon            361..535
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1486
                     /gene="Vasp"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 6"
                     /protein_id="NP_001425019.1"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKLQPD
                     QQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQFAIGMANALEALEG
                     GGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPPAPPAGGPPPPPGPP
                     PPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGSGAPGLAAAIAGAKL
                     RKVSKQEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQVGEKPPKDESASEE
                     SEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSSSDDSDLERVKQELV
                     EEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    398..697
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    398..697
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(404..406,425..427,569..571,575..577,593..595,
                     599..601,605..607)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(404..406,425..427,569..571,575..577,593..595,
                     599..601,605..607)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    1001..1081
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    1001..1081
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(1022..1027,1031..1036,1043..1045,1049..1063)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(1022..1027,1031..1036,1043..1045,1049..1063)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    1049..1060
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1049..1060
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1373..1471
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1373..1471
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            536..701
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            702..786
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            787..824
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1066
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1167
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1219
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1253
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1299
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1390
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1448
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..2282
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccctccag ccgggtccca gccgggaccc ggcttcgcgc cccgcctttg tccccctccc
       61 cccagctcgt tcggggctgg atttagggga cacagcgctt tgagcgtccc agatctgggc
      121 cgatgtctct tggagcgatc tctaaatatc gacaccccgt ttctccacac tactccctaa
      181 aggcttgggg cggtgccggc tgaggttctc ttgatggctt tcaggtttag gggcgctctc
      241 gggactcaga atttgaagac ttttgggggg agcacctccg agttcgcaga taagtagaac
      301 gtcgcaggga tgaactggta taagtgggct cagagttact gcccccaaac tcaaaaccag
      361 caacgagacg gtcatttgtt ccagccgggc tactgtgatg ctttacgatg acagcaacaa
      421 acgatggctt cctgctggca ccggtcccca ggcctttagc cgcgtccaga tctaccacaa
      481 ccccactgct aactctttcc gagttgttgg ccgcaagctg cagcctgacc agcaggtggt
      541 tatcaactgt gccatcattc gaggtgtcaa gtacaatcag gccactccca tattccacca
      601 gtggcgtgat gcccgccagg tctggggcct caacttcggc agcaaggagg acgctgcgca
      661 gtttgcgatc ggcatggcca atgccctgga ggccttggaa ggaggtgggc ctccccctgc
      721 cccagcaccc cctgcctggt ctacccagaa tggcccctcc ccagaggagc tggaacaaca
      781 gaaaaggcag cctgaacatt tggagcgccg ggtctccaat gcaggaggcc cacctgctcc
      841 cccagctggg ggcccacctc cacctccagg acctccccct cctccgggtc cccccccacc
      901 cccaggtctg cccccctcag gggtatctgg ggcaggtcat ggaacaggtg tagccccacc
      961 ccctgcaccc ccactcccta cagcacaggg ccccagtagt gggggttccg gggccccagg
     1021 cctggccgct gccattgctg gagccaaact caggaaagtg agcaagcagg aggaggcctc
     1081 tggggggccc ctggccccca aagctgagaa tagtcgaggc actggtgggg ggcttatgga
     1141 agagatgaac gccatgctgg cccggagaag gaaagccaca caggttgggg agaagccccc
     1201 caaagacgag tcagccagtg aggagtcaga ggcccgaatc cctgcccaaa gtgaacctgt
     1261 gcgaagaccc tgggagaaga acagcacaac cttgccaagg atgaagtcat cctcttctgt
     1321 gactacctcc gaggcccacc cctctgtgcc cagctccagt gatgactccg acttggagag
     1381 ggtgaagcag gagcttgtgg aagaggtgcg gaaggagcta cagaaaatga aagaggaaat
     1441 aatcgaagtc tttgtccagg agctgaggaa gcggggttct ccttgactac agggacccag
     1501 aagacccatt tcttcttttt gtacttcctg cctggcacct gctttccctg cctcaacttg
     1561 accaagagtt acacaagaat gcgttctccc ctaccagctc ccacttggaa gattccacag
     1621 gggtgtggct tcctggtgcc gtggtcacac ccacgctggc tgctgattgg ataaggaggt
     1681 cccacccctt tgttcccttt ggtccttccc cttcaccatc cccttggagc tggttcctct
     1741 gctggggatg taagagtaac cccacagtaa gggaaggaag gaggggatct caccttctct
     1801 tgttctggat tcactttaac gctttaatgc cttggaattt ttttttttaa gaaaaagtat
     1861 atatatatat ttgggttttg tggggggaag ggaaattttt tgttctcttt ggttttgata
     1921 aaatggggtg tgggagtttt taaatgctat accccaagct ttgtcccatc agaggcagct
     1981 atgtaagagg aggggtatcc caccaagtag ggggcatttc ccccacccct gggatacctc
     2041 cccatttgcc ttggctcctc tctcttttct ataaggaatt aagattcttt aacttttttg
     2101 gaacctcagt tttgtggttt tttttatttg ggttaggatt tcagggtcca gaccattttt
     2161 gccctccagg aagacgaagt gagggggagg agaagaggaa aaataggtcc tccgacttct
     2221 acaccatagc ttcttggaca cgggccctcg ctgaataaat ctgcagtttt tataaatgca
     2281 aa
//
LOCUS       NM_001438064            6406 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 5, mRNA.
ACCESSION   NM_001438064 XM_006231501
VERSION     NM_001438064.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6406)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6406)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6406)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6406)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6406)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6406)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6406)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6406)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6406)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6406)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231501.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5861.1,
                                           SRR26643292.6685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-1046            JAXUCZ010000001.1  255060666-255060813
            1047-1270           JAXUCZ010000001.1  255061098-255061321
            1271-1439           JAXUCZ010000001.1  255062205-255062373
            1440-1651           JAXUCZ010000001.1  255063221-255063432
            1652-1750           JAXUCZ010000001.1  255063987-255064085
            1751-1945           JAXUCZ010000001.1  255069136-255069330
            1946-2135           JAXUCZ010000001.1  255069541-255069730
            2136-2276           JAXUCZ010000001.1  255069954-255070094
            2277-2365           JAXUCZ010000001.1  255070390-255070478
            2366-2568           JAXUCZ010000001.1  255071464-255071666
            2569-2692           JAXUCZ010000001.1  255072193-255072316
            2693-2818           JAXUCZ010000001.1  255072589-255072714
            2819-2901           JAXUCZ010000001.1  255072981-255073063
            2902-3138           JAXUCZ010000001.1  255073935-255074171
            3139-3232           JAXUCZ010000001.1  255074448-255074541
            3233-3409           JAXUCZ010000001.1  255074797-255074973
            3410-3474           JAXUCZ010000001.1  255075722-255075786
            3475-3598           JAXUCZ010000001.1  255075873-255075996
            3599-3670           JAXUCZ010000001.1  255076149-255076220
            3671-3765           JAXUCZ010000001.1  255076331-255076425
            3766-3919           JAXUCZ010000001.1  255076801-255076954
            3920-4145           JAXUCZ010000001.1  255081461-255081686
            4146-4306           JAXUCZ010000001.1  255082250-255082410
            4307-4553           JAXUCZ010000001.1  255082513-255082759
            4554-4747           JAXUCZ010000001.1  255082874-255083067
            4748-4898           JAXUCZ010000001.1  255085207-255085357
            4899-5029           JAXUCZ010000001.1  255085463-255085593
            5030-5131           JAXUCZ010000001.1  255085758-255085859
            5132-5245           JAXUCZ010000001.1  255086114-255086227
            5246-5426           JAXUCZ010000001.1  255086358-255086538
            5427-5555           JAXUCZ010000001.1  255086830-255086958
            5556-6406           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6406
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5836
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 5 is encoded by transcript variant 5;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 5"
                     /protein_id="NP_001424993.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVMPGSELPTPNGAALSSNLTGGMPFIEAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQAGSPREITTTEPGSTEIGVSDQL
                     DPQQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPRGVRFTQSSQK
                     EGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTL
                     LGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIIT
                     VENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFP
                     VSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTY
                     KSERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPP
                     RFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQW
                     LRENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPV
                     IHRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFR
                     KNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGATPEGI
                     FLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLS
                     DVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKN
                     IMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSG
                     PEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDE
                     ETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGL
                     LRLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGD
                     DWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSD
                     SEVYTDHGRPGKMHRSATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSL
                     TVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQ
                     DKRGKSHKYDSKGNRFKKKPKEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVS
                     LQLLDLMHTLHTRAASIYSSWAEEQRHLETGGRKIEADSRTLWAHCWCPLLQGIACLC
                     CDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGG
                     MEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAVPE
                     SLKNMLLVMDTAEIFHSADARGGSPSALWEITWERIDCFLPHLRDELFKQTVIQDPMP
                     TEPHSQKPLASTHLTPAAGDPRMPGHPPPPEIPSEVGACDPEKPESTRAASSSSPGSP
                     VASSPSKQSPAPEGPPPLAQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSPVPL
                     LATPRPTDPIPTSEVN"
     misc_feature    <1547..>3796
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1547..>3796
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2357..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2357..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5435..5827
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5435..5827
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1270
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1439
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1651
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1750
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1945
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2135
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2276
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2365
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2568
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2692
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2818
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2901
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3138
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3232
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3409
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3474
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3598
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3670
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3765
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3919
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4145
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4306
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4553
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4747
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4748..4898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..5029
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5131
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5245
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5246..5426
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5555
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5556..6406
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagct
      901 gaaaatgaga gcaggaggca tgagtgactc atccaagtgg aagaaacaga agcgatcccc
      961 tcgacctcca cgtcatacaa ccaaagtcat gccaggttca gagctgccca ccccaaatgg
     1021 agccgcctta tcctctaacc ttactggtgg catgcccttc attgaggcac ccacatccat
     1081 ctcctctgca agttcagaag ctgcctccac agtggtcagt ccctgtacag atagtggcct
     1141 ggaattatcc tcccaggcta cctccaagga ggacctcacc gacctggagc aagctggctc
     1201 cccaagggag atcaccacca cagagcctgg gagcactgag ataggagttt ctgatcagct
     1261 tgaccctcag caggaagggg cccatgtaga aaaggcccag tcagcatcgg tggaatctat
     1321 ccctgaagtg ctagaggagt gcacatcccc tactgaccat tctgactctg cctctgtcca
     1381 tgacatggat tatgtcaatc ctcggggcgt gcgctttacc cagtcctccc agaaagaagg
     1441 cacagctttg gttccttatg gtcttccttg catccgtgag ctcttccgct tccttatctc
     1501 cctcacaaat ccacatgacc gccataactc tgaggttatg atccacatgg gacttcattt
     1561 gctgacagta gctcttgagt cagcccctgt ggcccagtgc cagaccctct tgggtctcat
     1621 caaggatgag atgtgccgac acttattcca gctactcagc gtagagcggc tgaaccttta
     1681 cgctgcttcc ctacgagtgt gctttttgct ctttgagagc atgcgggaac acctcaagtt
     1741 ccagttggag atgtacatca aaaagctcat ggagattatc actgttgaaa accccaagat
     1801 gccttatgag atgaaggaga tggcgctgga ggccattgtg cagctctggc gcatccccag
     1861 cttcgtcacg gagctctaca tcaactatga ctgtgactac tactgctcca acctcttcga
     1921 agacctcact aagctgctgt ccaagaatgc ctttcctgtg tctggccagc tttatacaac
     1981 acacctgctg tctcttgatg ccctattgac agttattgac agcactgagg ctcattgtca
     2041 ggccaaagtc ctcaacaccc tcaaccagca agagaagaaa gagacagcca gacctggctt
     2101 tgaggcagtg gatggcagcc cagacactta caagtctgag agagcagcca gtgatgggaa
     2161 agccacagga gtgccctcag atgctccagg ccttcatttt tcaagtggag ggtggttgtc
     2221 aacagaacat ggaaagccag ggtgcagtga tctggaggaa gctggtgact ctggggttga
     2281 caaaaagacc accaggaagc cacctcgatt ttcctgtctt ctgccagatc cacgggaact
     2341 aattgaaatt aaaaacaaaa aaaagctgct gatcactggt acagagcagt tcaaccaaaa
     2401 accaaagaag gggatccagt ttctgcagga gaaaggcctc ctcaccatcc caatggataa
     2461 cacagaggta gcccagtggc tccgagaaaa ccctcggcta gacaaaaaaa tgattggaga
     2521 gtttgtgagt gaccgcaaaa acatggacct gttggagagt tttgtgagca ccttcagctt
     2581 ccagggtctg aggcttgatg aggctctccg cctctaccta gaagccttcc gtctgcctgg
     2641 ggaagcgcct gttattcaca ggctgctgga ggtgttcact gagcactgga ggagttgtaa
     2701 tggctcccca tttgctaata gcgatgcctg ctttgccctg gcctatgctg ttatcatgct
     2761 taacactgac caacataacc acaatgttcg caagcaaaat gcacccatga ccctggagga
     2821 gttccgcaaa aacctgaaag gtgtgaatgg aggcaaggac tttgagcaag acatcctgga
     2881 agacatgtac catgccatca agaatgagga aattgtgatg cctgaggaac aaacaggtct
     2941 ggttcgtgag aattatgtgt ggagtgtgct gcttcatcga ggtgctaccc ctgagggcat
     3001 cttccttcgt gtaccccctg gcagctatga tcttgacctc ttcactatga cctggggccc
     3061 cactattgct gctctctctt atgtgttcga taaaagcctc gaggagacca tcatccagaa
     3121 agccatctca ggcttcagga agtgtgccat gatctccgcc cactatggcc tcagcgatgt
     3181 gtttgacaat ctcatcatct ctctgtgcaa attcacagct ctaagtagtg agtctattga
     3241 gaacctgccc agtgtattcg gaagcaaccc taaagcccac attgcagcca agacagtatt
     3301 ccatttggcc catcgtcatg gtgacatcct tcgggagggc tggaagaata tcatggaggc
     3361 catgctgcag ctcttccgag cccaactttt accgaaggct atggtagagg tagaagattt
     3421 tgtggatccc aatggtaaga tctctctaca gcgggaggag acaccatcaa accgaggaga
     3481 gtcaacagtc cttagttttg taagctggct gacactgagt ggtcctgagc agtccagtgt
     3541 ccggggccca tcgacagaga accaagaggc caagcgagta gccttggact gcatcaagca
     3601 atgtgaccca gaaaagatga tcacagaaag caagttcctc cagctggaat ctctgcagga
     3661 gctcatgaag gctctggtct cggtgacacc agatgaagag acatatgatg aagaagatgc
     3721 tgctttctgt ctggagatgc tgctaaggat tgtgttagaa aacagggacc gtgtgggctg
     3781 tgtatggcag actgttcgag atcatctata ccacctgtgt gttcaggcac aagatttctg
     3841 cttccttgtg gagcgagcag tggtagggct gctacgccta gccattcggc tactccgaag
     3901 agaagagatt agtggccagg tcctgctctc tctgcgcatc ttgttactga tgaagcccag
     3961 cgtgctgtcc agagtcagcc accaggtcgc ttatgggctg catgaactcc tcaagaccaa
     4021 tgctgccaac atccactcgg gtgatgactg ggccactctc ttcacattgc tggagtgcat
     4081 tggctcaggc gtgaagcctc cagatgctct acaagccaca gccagggctg atgctcctga
     4141 tgctggagca caatccgaca gtgagctccc atcctaccat caaaatgatg tcagcctaga
     4201 ccgagggtac acttccgact cagaagtcta cactgaccat ggcaggcctg gcaagatgca
     4261 ccgatcagcc acagacgctg acatggccaa cagtggttgg ttagtggtgg ggaaggatga
     4321 cattgataac tccaaaccag cagcaggact cagcaggcca ggcccttcgc ccttggtcaa
     4381 tcagtacagc cttacagtgg gcctggacct gggaccacat gacactaagt ccttgcttaa
     4441 gtgtgtggag tctctgtcct tcattgttcg tgatgctgct cacatcaccc ctgacaactt
     4501 tgaactctgc gtcaagaccc tccgcatctt tgtagaagcc agtctgaatg gtgggtgcaa
     4561 gtcccaggat aaacgtggca agagtcataa atatgacagc aaagggaacc ggttcaagaa
     4621 aaagcccaag gagggctcga tgcttcggcg gccccgggca tccagccagc atgccactcg
     4681 ggctggacac agtgatgaag aggaggacga aggcgtgcct gccagctacc atacggtgtc
     4741 tttacagttg ctagacctga tgcacaccct gcacacacgg gcagcctcta tctacagttc
     4801 atgggcagag gagcaacgcc acctggagac aggtggccgg aagattgaag ctgactcacg
     4861 taccctctgg gcccactgct ggtgcccttt attacaaggt atcgcttgct tatgctgtga
     4921 cgcccggcgc caggtgcgga tgcaggccct gacatatctc cagcgagccc ttctggtaca
     4981 tgacctgcaa aagctagatg ccctggaatg ggagtcctgt tttaacaagg tgctgtttcc
     5041 gctactgacc aagcttttag aaaatatcag ccctgcggat gtgggcggga tggaggagac
     5101 ccggatgcgg gcttccacac tgctctcaaa ggtcttcctg cagcacctgt ccccactgct
     5161 gtccctgtcc acctttgctg ccctgtggct caccatcctg gacttcatgg acaagtacat
     5221 gcacgcaggt tccagtgact tgctgtcaga agctgtccct gagtctctga agaacatgct
     5281 ccttgtgatg gacacagcag agattttcca cagtgcagat gcaaggggag gcagcccctc
     5341 tgctctctgg gagatcacct gggagcgcat cgattgcttc ttaccacacc tacgtgatga
     5401 actcttcaag cagactgtca tccaggaccc catgcccaca gagcctcaca gtcaaaaacc
     5461 tctggcttct actcacctga cgcctgctgc tggtgacccc aggatgcctg gccatccacc
     5521 tcctccagag ataccctcag aagtgggagc ttgtgacccg gagaagcccg agagcaccag
     5581 agctgccagc agcagctccc ctggatcgcc ggtggcctct agccccagca aacagagtcc
     5641 tgccccagag ggacctcccc cactggccca gcccccacta atcctacagc ccttgacctc
     5701 cccactgcag gtgggggtac cacccatgac tttgcccatc atcctcaacc ctgcactcat
     5761 tgaggccacc tctccagtgc ctctcttagc cacgccacgc cctacagacc ccatccccac
     5821 ctctgaggtc aactaaggca gccactcaga ggtcaggacc attccttcct atcaggcatt
     5881 caaggccctg cttccagtcc caggggccac agaaatcttc aggcccaaag caagctgctg
     5941 ttaccactgc ttgacagggg gatgacgatg tttatagtcc ctgctgggat ccactccagg
     6001 ctgcgaggtt cttcctctgc cgttcagtcc tgaacttcca agctgagagt ggatgcaggc
     6061 tgaacctgta gcctctgcct ctggcctggc agccctgggg aggcatagag ccaaccctgc
     6121 tgtgccaacc ctgcagtgcc tgccatgtgc cccctgccag gttgggcatt aggagccaag
     6181 cccgacctct ctgcactttg ttcctctccc tatccagtcc atcagtcctg ggccactgcc
     6241 tccagttctt cttccttcat taaatagttg gtcagtttgg agtcgcttgg caccatggag
     6301 ggtggacagg taggactcga tggggggtct gcccacagga gcatgtacat atggaaaaat
     6361 aacattggac tttttatgat ataataaatg tcttagtacc aacaca
//
LOCUS       NM_001438087            2223 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 4, mRNA.
ACCESSION   NM_001438087
VERSION     NM_001438087.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2223)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2223)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2223)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2223)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2223)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2223)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2223)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2223)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1724454.1,
                                           SRR21887623.3178864.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  88052773-88053076   c
            305-479             JAXUCZ010000001.1  88045950-88046124   c
            480-645             JAXUCZ010000001.1  88045709-88045874   c
            646-730             JAXUCZ010000001.1  88043417-88043501   c
            731-768             JAXUCZ010000001.1  88042666-88042703   c
            769-1010            JAXUCZ010000001.1  88042312-88042553   c
            1011-1108           JAXUCZ010000001.1  88042068-88042165   c
            1109-1160           JAXUCZ010000001.1  88040749-88040800   c
            1161-1194           JAXUCZ010000001.1  88040554-88040587   c
            1195-1240           JAXUCZ010000001.1  88040283-88040328   c
            1241-1331           JAXUCZ010000001.1  88040092-88040182   c
            1332-1389           JAXUCZ010000001.1  88038970-88039027   c
            1390-2223           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2223
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..304
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     CDS             300..1427
                     /gene="Vasp"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 4"
                     /protein_id="NP_001425016.1"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MSNETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPT
                     ANSFRVVGRKLQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQ
                     FAIGMANALEALEGGGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPP
                     APPAGGPPPPPGPPPPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGS
                     GAPGLAAAIAGAKLRKVSKEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQV
                     GEKPPKDESASEESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPSSS
                     DDSDLERVKQELVEEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    945..1016
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    945..1016
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1314..1412
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1314..1412
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            305..479
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            646..730
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            731..768
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1010
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1108
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1160
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1194
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1240
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1331
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1389
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..2223
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtagtaa gagtaaccgc gtaggtgctg ccggctgagg gggtgcgccg gcgaggttcg
       61 gacgctgcac cccgctttcc atcgcagggg atcccagcac atcagagcac cggagggagg
      121 aggcgcctga gcacccgccc gggcccggtc cacgttctcc ccaggaagct ggactctatg
      181 gggcgggacc ccgagagaga ctgagcagaa cctggagcca gccccgcacc cctgcacttc
      241 caatcagggg cgccccggga gcactccccg tgggcgcgcc gcctgccctc tgcgcagcca
      301 tgagcaacga gacggtcatt tgttccagcc gggctactgt gatgctttac gatgacagca
      361 acaaacgatg gcttcctgct ggcaccggtc cccaggcctt tagccgcgtc cagatctacc
      421 acaaccccac tgctaactct ttccgagttg ttggccgcaa gctgcagcct gaccagcagg
      481 tggttatcaa ctgtgccatc attcgaggtg tcaagtacaa tcaggccact cccatattcc
      541 accagtggcg tgatgcccgc caggtctggg gcctcaactt cggcagcaag gaggacgctg
      601 cgcagtttgc gatcggcatg gccaatgccc tggaggcctt ggaaggaggt gggcctcccc
      661 ctgccccagc accccctgcc tggtctaccc agaatggccc ctccccagag gagctggaac
      721 aacagaaaag gcagcctgaa catttggagc gccgggtctc caatgcagga ggcccacctg
      781 ctcccccagc tgggggccca cctccacctc caggacctcc ccctcctccg ggtccccccc
      841 cacccccagg tctgcccccc tcaggggtat ctggggcagg tcatggaaca ggtgtagccc
      901 caccccctgc acccccactc cctacagcac agggccccag tagtgggggt tccggggccc
      961 caggcctggc cgctgccatt gctggagcca aactcaggaa agtgagcaag gaggaggcct
     1021 ctggggggcc cctggccccc aaagctgaga atagtcgagg cactggtggg gggcttatgg
     1081 aagagatgaa cgccatgctg gcccggagaa ggaaagccac acaggttggg gagaagcccc
     1141 ccaaagacga gtcagccagt gaggagtcag aggcccgaat ccctgcccaa agtgaacctg
     1201 tgcgaagacc ctgggagaag aacagcacaa ccttgccaag gatgaagtca tcctcttctg
     1261 tgactacctc cgaggcccac ccctctgtgc ccagctccag tgatgactcc gacttggaga
     1321 gggtgaagca ggagcttgtg gaagaggtgc ggaaggagct acagaaaatg aaagaggaaa
     1381 taatcgaagt ctttgtccag gagctgagga agcggggttc tccttgacta cagggaccca
     1441 gaagacccat ttcttctttt tgtacttcct gcctggcacc tgctttccct gcctcaactt
     1501 gaccaagagt tacacaagaa tgcgttctcc cctaccagct cccacttgga agattccaca
     1561 ggggtgtggc ttcctggtgc cgtggtcaca cccacgctgg ctgctgattg gataaggagg
     1621 tcccacccct ttgttccctt tggtccttcc ccttcaccat ccccttggag ctggttcctc
     1681 tgctggggat gtaagagtaa ccccacagta agggaaggaa ggaggggatc tcaccttctc
     1741 ttgttctgga ttcactttaa cgctttaatg ccttggaatt ttttttttta agaaaaagta
     1801 tatatatata tttgggtttt gtggggggaa gggaaatttt ttgttctctt tggttttgat
     1861 aaaatggggt gtgggagttt ttaaatgcta taccccaagc tttgtcccat cagaggcagc
     1921 tatgtaagag gaggggtatc ccaccaagta gggggcattt cccccacccc tgggatacct
     1981 ccccatttgc cttggctcct ctctcttttc tataaggaat taagattctt taactttttt
     2041 ggaacctcag ttttgtggtt ttttttattt gggttaggat ttcagggtcc agaccatttt
     2101 tgccctccag gaagacgaag tgagggggag gagaagagga aaaataggtc ctccgacttc
     2161 tacaccatag cttcttggac acgggccctc gctgaataaa tctgcagttt ttataaatgc
     2221 aaa
//
LOCUS       NM_001438077            4453 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            1 (Sorcs1), transcript variant 2, mRNA.
ACCESSION   NM_001438077 XM_006231521
VERSION     NM_001438077.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4453)
  AUTHORS   Yau,B., Blood,Z., An,Y., Su,Z. and Kebede,M.A.
  TITLE     Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1
            gene results in alternative processing of the Sorcs1 protein in
            INS1 beta-cells
  JOURNAL   Sci Rep 9 (1), 19466 (2019)
   PUBMED   31857633
  REMARK    GeneRIF: Type 2 diabetes-associated single nucleotide polymorphism
            in Sorcs1 gene results in alternative processing of the Sorcs1
            protein in INS1 beta-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4453)
  AUTHORS   Ribeiro,L.F., Verpoort,B., Nys,J., Vennekens,K.M., Wierda,K.D. and
            de Wit,J.
  TITLE     SorCS1-mediated sorting in dendrites maintains neurexin axonal
            surface polarization required for synaptic function
  JOURNAL   PLoS Biol 17 (10), e3000466 (2019)
   PUBMED   31658245
  REMARK    GeneRIF: SorCS1-mediated sorting in dendritic endosomes controls
            Nrxn axonal surface polarization required for proper synapse
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4453)
  AUTHORS   Lazar,J., O'Meara,C.C., Sarkis,A.B., Prisco,S.Z., Xu,H., Fox,C.S.,
            Chen,M.H., Broeckel,U., Arnett,D.K., Moreno,C., Provoost,A.P. and
            Jacob,H.J.
  TITLE     SORCS1 contributes to the development of renal disease in rats and
            humans
  JOURNAL   Physiol Genomics 45 (16), 720-728 (2013)
   PUBMED   23780848
  REMARK    GeneRIF: The experimental data from the rat combined with
            association results from different ethnic groups indicates a role
            for SORCS1 in maintaining proper renal function.
REFERENCE   4  (bases 1 to 4453)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231521.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8485.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-807               JAXUCZ010000001.1  259534929-259535735 c
            808-875             JAXUCZ010000001.1  259355251-259355318 c
            876-975             JAXUCZ010000001.1  259269929-259270028 c
            976-1134            JAXUCZ010000001.1  259220306-259220464 c
            1135-1208           JAXUCZ010000001.1  259199649-259199722 c
            1209-1273           JAXUCZ010000001.1  259175137-259175201 c
            1274-1392           JAXUCZ010000001.1  259148966-259149084 c
            1393-1482           JAXUCZ010000001.1  259146699-259146788 c
            1483-1662           JAXUCZ010000001.1  259140159-259140338 c
            1663-1809           JAXUCZ010000001.1  259128292-259128438 c
            1810-1912           JAXUCZ010000001.1  259112543-259112645 c
            1913-1989           JAXUCZ010000001.1  259112203-259112279 c
            1990-2081           JAXUCZ010000001.1  259110150-259110241 c
            2082-2189           JAXUCZ010000001.1  259107925-259108032 c
            2190-2307           JAXUCZ010000001.1  259106215-259106332 c
            2308-2438           JAXUCZ010000001.1  259104606-259104736 c
            2439-2552           JAXUCZ010000001.1  259101597-259101710 c
            2553-2724           JAXUCZ010000001.1  259088686-259088857 c
            2725-2911           JAXUCZ010000001.1  259067695-259067881 c
            2912-3045           JAXUCZ010000001.1  259059499-259059632 c
            3046-3169           JAXUCZ010000001.1  259057964-259058087 c
            3170-3282           JAXUCZ010000001.1  259052351-259052463 c
            3283-3414           JAXUCZ010000001.1  259051331-259051462 c
            3415-3514           JAXUCZ010000001.1  259044613-259044712 c
            3515-3620           JAXUCZ010000001.1  259031690-259031795 c
            3621-4453           JAXUCZ010000001.1  259022007-259022839 c
FEATURES             Location/Qualifiers
     source          1..4453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4453
                     /gene="Sorcs1"
                     /note="sortilin-related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
     exon            1..807
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3828
                     /gene="Sorcs1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; VPS10 domain-containing receptor SorCS1; VPS10
                     domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1 isoform
                     2 precursor"
                     /protein_id="NP_001425006.1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
                     /translation="MGKVGAGDGSSAALSALLTGAGLLMLLAPGICSSLSCCPPQHPS
                     STPRWTLTPRGFSYPGPLGRAPATPPPLFMRPLFAVAPGDRALFLERAGGSRVSVATA
                     SRSGRRRRSGMDPEKTEPGEGTSRSRRDMLRDGGQQGPGTGARDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNRFYWSVLGSNKEPDLVHL
                     EARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYV
                     SYRRNPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     ADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELSDSDI
                     SMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGTYAGAMESEPCVCTEADFDCDYGYERHSSG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPT
                     AAELFVLPYQDGARENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRGWRDRSAVKNIGCSCRGPGFNA
                     QHQQGGSQASVTSVPRDTTPSSDLHGHQEHTWCTDLHPGKTPIHIK"
     sig_peptide     250..348
                     /gene="Sorcs1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    835..2628
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    835..2628
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    2668..2889
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2668..2889
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2755..>3168
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     misc_feature    2755..>3168
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     exon            808..875
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..975
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1134
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1208
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1273
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1392
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1482
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1662
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1809
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1912
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1989
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2081
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2189
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2307
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2438
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2552
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2724
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2911
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3045
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3169
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3282
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3414
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3514
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3620
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..4453
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccacccccg cgcagcggcg gcggcggcgg cggtggctcg cagctccgtc ccaacccgcg
       61 cgctcctcac aagcccagcc tgggcgagcg gcaggcacct gcccggcgcc gcctccgcgc
      121 gccccgccgc cgcccaactt ggatggagtt gtggtcctga gcgcacaccc tgccgccgtc
      181 agcccagtgc ctcgctccgc tgcctgcctt cggttcggga ccccctctcc gctcctctcc
      241 gctccagaga tgggaaaagt tggcgccggg gacggctcct cggccgcgct tagcgcgctc
      301 ctaacgggag ccgggcttct gatgctctta gcccctggca tctgcagcag cctttcttgc
      361 tgccctccgc aacaccctag ctcgacccca cgctggaccc ttaccccaag aggcttttct
      421 taccccggac cgctgggtcg ggctcctgcc acgcccccgc ccctcttcat gagacccctg
      481 ttcgcagtgg cccccgggga ccgggcgctg tttctggagc gagctggggg cagcagggtg
      541 tcagtggcga ccgcttcacg ctctggccgt aggagacgga gtggaatgga tcctgagaag
      601 actgaacccg gagagggtac gagtcggagc cgccgggaca tgctaaggga tggagggcag
      661 caggggcctg ggactggcgc gcgggacccg gacaaagcca ctcgcttccg gatggaggag
      721 ctgagattga ccagcaccac atttgcgctg actggagact cggcacacaa ccaagctatg
      781 gtccactggt ctggccacaa cagcagcgtg attctcattt tgacaaagct ctatgactat
      841 aacctgggaa gcatcactga gagctcgctt tggaggtcaa ccgattatgg gacaacctac
      901 gagaagctga atgataaagt ggggttgaag accattttga gctatctcta tgtgtgccca
      961 accaacaagc gtaagattat gctactcacg gacccggaga ttgagagcag tttgttgatc
     1021 agctcagatg aaggggcaac ctatcaaaag taccggctca acttttacat ccagagtttg
     1081 cttttccatc cgaagcaaga agactggatc ctggcctaca gtcaagacca aaagttatac
     1141 agctctgctg agtttggcag aagatggcag cttatccagg aagcagtggt acccaatagg
     1201 ttttactggt ctgtgctggg gtcgaacaaa gaaccagacc ttgtgcatct cgaggccagg
     1261 accgtagatg gtcactccat atacttaact tgtcggatgc aaaactgcac tgaagccaac
     1321 agaaataaac ctttcccagg atacattgac ccggattctt tgattgttca ggatgattat
     1381 gtgtttgttc agctcacatc aggaggaaga ccacattact atgtgtccta ccgaagaaac
     1441 ccatttgcac aaatgaaact tccgaaatat gctttgccca aggatatgca tgtcatcagt
     1501 acggatgaga atcaggtgtt tgcagcagtt caagaatgga accagaatga cacctacaac
     1561 ctgtacatct cagacacacg cggggtctac ttcacgctgg ccttggagaa cgtgcagagc
     1621 agcagaggcc ctgaaggcaa tgtcatgatt gacctttatg aggtagcagg gataaaggga
     1681 atgttcttgg ctaacaagaa gattgacaac caagtgaaga ctttcatcac ttacaacaaa
     1741 ggcagagact ggcgtttgct gcaggctcca gatgcagatc taagggggga ccctgtgcac
     1801 tgtttgctgc cctactgttc actacacctt catctcaaag tttctgagaa tccctacaca
     1861 tctgggatca ttgccagcag agacacagcc ccaagtatta tagttgcatc aggtaacata
     1921 ggctctgagt tgtcagacag cgacatcagc atgtttgtat catcagatgc agggaacact
     1981 tggaggcaga tttttgaaga agagcacagc attttgtacc ttgatcaagg gggagtcctg
     2041 gttgctatga aacacacatc tctcccaatt cggcacctgt ggttgagttt tgatgaaggg
     2101 aggtcttgga gcaaatacag ttttacatcc attccacttt ttgtggatgg agtcctgggg
     2161 gagcctggag aagagacact aatcatgaca gtgtttggac acttcagtca tcgttctgag
     2221 tggcagctgg tcaaagtgga ttacaagtcc atttttgaca gacgctgtgc tgaagaagac
     2281 tacagaccct ggcagttaca tagccagggg gaagcatgca tcatgggagc caagaggatc
     2341 tataagaagc gaaaatctga gcgcaagtgt atgcaaggga cgtatgcagg agcgatggag
     2401 tctgagcctt gtgtgtgtac agaggcggac tttgactgtg actatggcta cgagagacat
     2461 agtagtggac aatgcctacc agcattttgg ttcaacccgt cctcactgtc aaaagactgc
     2521 agcttgggac agagttacct caacagcact gggtacagga aggtggtctc caataactgc
     2581 acggacggag tgagggaaca gtacaccgcc aaaccacaga agtgtccagg gaaggcccct
     2641 cgtgggctac ggattgtcac tgcagatggg aaactgacag cagaacaggg gcacaatgtc
     2701 actctcatgg tgcagttgga agagggggat gtacagcgga cactcatcca agtggacttt
     2761 ggagatggca ttgcggtgtc ttatgtcaac ctcagctcga tggaagacgg aatcaagcat
     2821 gtatatcaga atgtgggcat tttccgagtg accgtgcagg tggacaacag tctggggtct
     2881 gacagcgccg tcctgtactt acatgtaact tgtcccctgg aacatgtgca cctgtccctt
     2941 ccttttgtca caacaaagaa caaagaggtc aacgcaactg ccgtgctgtg gcccagccaa
     3001 gtgggcactc tcacttacgt gtggtggtat gggaacaaca cagagcccct gatcaccttg
     3061 gagggcagca tatcattcaa gtttacttct gaaggaatga acactatcac ggtacaggtc
     3121 tcagctggga atgccatact gcaagacact aagaccattg cggtatacga ggaattccgc
     3181 tctcttcgct tggctttttc tccaaacttg gatgactaca accctgacat cccggagtgg
     3241 aggagggaca tcagccgagt aatcaaaaag tctctggtgg aagccacagg gattcccagc
     3301 cagcatatcc tggtggcagt gttacctggc ttacccactg ctgctgagct ctttgttttg
     3361 ccctatcaag atggagctag agaaaacaaa aggtccccag aggacctgga gcagatatct
     3421 gaagttctaa tccacaaact caaccaaaac ttggtgcact ttgagctgaa gcctggggtc
     3481 caagttcttg tccacgcagc tcacctaaca gcagcccccc tggtggacct cactcctacc
     3541 cacagcggat ctgccatgct gatgttgctc tcagtggtgt ttgtggggtt ggccgtgttc
     3601 gtcatctaca agtttaaaag aggctggaga gatcgctcag cggtcaagaa cattggctgc
     3661 tcttgcagag gacccgggtt caatgctcag caccaacaag gtggctcaca ggcatctgta
     3721 acttcagttc cgagagatac gacaccctct tctgacctcc atgggcacca ggaacacacg
     3781 tggtgcacag atttacatcc aggaaaaaca ccaatacaca taaaatgaaa ataaaacgat
     3841 ttttataaag tacttagagg cataagaaaa tttttatgaa atgtgaagag aggaatttaa
     3901 gacgtcatgg ggtgaaataa tagtttgtat agaaagcaca gggcagagag catctcagcg
     3961 atagacttct tatttggcta aaacgcacag tgttctgatt caattctcca gtactgcata
     4021 tatatttaaa aataaagaag aagactggat ggaaatcaaa aagtatgacc ccttgctatt
     4081 tctaactccc taaaccatgg atgttttaat tcccttcatc tttaaaatga acatgtagtc
     4141 ctcgtagact tggactaaac ctatcttaaa taggaaacaa aaggaatgct tataaggaaa
     4201 tctatatgcc tattgaaccc ataccttaat tataaactgt gtatatagtt cctaggaaga
     4261 tcacaattat taaagtgtgt aattattctc ttcgaaaact aaaaattaaa ccactccgaa
     4321 tgtcattttt atcaattgaa attcatactg agatgaacat attactatgc tgtttttgta
     4381 tctgtaatct gtgaactttc tgaatatatt ctattcattt ttaattaaat ttttaggtta
     4441 tcgtgcaaag taa
//
LOCUS       NM_001438102            3785 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 7, mRNA.
ACCESSION   NM_001438102 XM_063266456
VERSION     NM_001438102.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266456.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1530787.1,
                                           SRR26360176.2185401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000001.1  94933032-94933340   c
            310-400             JAXUCZ010000001.1  94931143-94931233   c
            401-568             JAXUCZ010000001.1  94930658-94930825   c
            569-696             JAXUCZ010000001.1  94928181-94928308   c
            697-797             JAXUCZ010000001.1  94928000-94928100   c
            798-880             JAXUCZ010000001.1  94926045-94926127   c
            881-1035            JAXUCZ010000001.1  94925808-94925962   c
            1036-1214           JAXUCZ010000001.1  94923695-94923873   c
            1215-2130           JAXUCZ010000001.1  94922695-94923610   c
            2131-2212           JAXUCZ010000001.1  94922525-94922606   c
            2213-3785           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3785
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..309
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    285..287
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            310..400
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2354
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 7;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425031.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <993..1880
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <993..1880
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2100..>2234
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2100..>2234
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            401..568
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            569..696
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            697..797
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            798..880
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1035
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1214
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2130
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2212
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..3785
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag gtgaggttgg tccgtctttc
      121 agtgaccaca ggaggccttg gggaaggcaa cacgggttta caagagcctg gagtctccgg
      181 cccaacctta cgagaactac aactcccaag atactaagca gtttggtcgc tccggcatct
      241 ctgactgacg tcttttgttc tttctgggtg ggcctaacgg agtctaaaag aaatttgaaa
      301 atttagttct cagttttcac ctcccaagac agcccttgga aatgttcccc aaggtggaca
      361 accctttaga ccatcaagaa gccagaactg gagccacaag gtctcaaaag ccacaagctc
      421 ccaaggccac agcagccaat tctgctgagc tgtctgagga gtcctggcca tccagttcag
      481 ggaccgcttc cccacccagt accactgagg gacagagtac ctctccaccc ctcaccttaa
      541 ttgacaacga ggactcagtg gtggccaagt acataaaccg gttccgcaaa gctcagccca
      601 cgagccgaga ggaccgccag cccgtgggcc caaccccagc tgacttttgg tggctacagc
      661 ctgcgtcttc agacctcagc agtcaccttg cagcaggagc tggtgaacct acaggaagat
      721 ctgccgtgac aggtccatgt cccaccggga tgtccagtac gtctctggct tctgtgcctc
      781 ttcagagagt aaagcagagt ctgaactctt ggaactcggc tatgctggag ctggagaccc
      841 tgagccttca aagccgagcg gccaagctgc tggaacgcag caaggcctcc ctctcctcct
      901 cctcctcctc ccccagtccc aacgaagcca gcagctcctc cttccccatc agctctgacg
      961 gcctctctcc ctgctctgtg accttcaatc cggactccaa caagagttct agtcccaaag
     1021 aacccgtgct gggagcagcc ccagtgccat cccaggccat ccctgcaccc cgcccagcct
     1081 ctgcccaggc aacccttaag cctgaggaag acattttata ccaatggagg caacggagga
     1141 agcttgagca gtctctacaa ggtgcaggtg atggaacctg ggtgttgcct cggacaccag
     1201 ccctcactac tcagactcct gtctctgcag tgaatcttgg ttccaagggg acccaaccta
     1261 actgtgctcc accatggggc agtgtggccc agcctcctcc cccacaggca ttctatatgg
     1321 agaggccacc tctttcaggg ccctctccac acatctgggc ccccggcaca cacggggttc
     1381 tctgggcccc acaggccaat ccctggatac ctcttgggat ggttcctacc acactgctaa
     1441 cctccaccct tgctcccttg gcctccttac cagtaccacc tacctccact tcagctgcca
     1501 cagcccccat ctctgctccc caggtctcca tcccagggcc cccagcctct gccccacctc
     1561 cctgcacttc tgccccagct tccaccgtcc cactacctga caacccccag ggaccaacca
     1621 cccctgagtt gagtagctct gtccatccca agaagctgag ccccaagcct cgctgtgtga
     1681 gcgcttcgtc tcgtcaggag actactggac cagacactgc agctttcgag agtccctgtt
     1741 ctcagcttag gggggctctg agccaggtag tgacagctcg gctgttctcc gacagcctgg
     1801 aggatatgcc tccatctgaa gcagattccc ggaaagtcaa ggccacctcc tctcaagcca
     1861 aagttccgcc ccctccacct gagtcccggc gtgggtccaa gacagagtcc cgcaaaagta
     1921 aagtcaccct ctcagctgaa gctggggatc cacagccggc tacagcccca aaggcatcca
     1981 cactgtcaga ggtccaatca cttgaattca agaagtctac acccaagaag ggagctggtg
     2041 acgccttgac tacggccccg cctgcctcaa gccacgcccc ttccgaggac ttgctatccc
     2101 aggccgctag acttctgcag gctgcggaag actctgacgg cagcgagttt ccggaagact
     2161 ctgtgttgcg agtgctaagg gctcagaggg cagaactaag gcagcagaaa aggaatgtgg
     2221 atgcccaatt atccctcctc ttggaccaca ctgaagaccc aggattttca tctcctccag
     2281 ccaggtcacc ttccagttcc ccaagaatgc ggttaaggag ggaaggagcc tcccttgagg
     2341 ccagacgacc ttgaatcata aacattgttt ttcctgggct ggggaggtgg ctcagtgggt
     2401 aaagcacttg caagtgtgaa gacccgagtt tagatcccca gaacccacat aaaggtaact
     2461 gacaggccag ctggtccatg gagacagggt ctcaatcaag gtggaaatca aagaccaatc
     2521 tctgaaattc tctgacttcc acacaagagc tgtggggtgt ggtgcacata acacaggcac
     2581 gcacacacag gcacacacac acacggacgc acacatgcgc tcgcgcacgc acacacacac
     2641 acacacacac atacacaggc acacacacta aagttgtccc caattaatat ttttccagtt
     2701 tactgttaat ctctaagaaa tgggttgttg tagaaaggct gattgtgcta ataaggaaat
     2761 gtagctcttc cctaactact gaaacaaagt ttcttctctc tagccctcct tcccaccccc
     2821 tctctctgat atccctcccc ctctctctcc ccgggagcac atggctctag gtaatgtggg
     2881 cacctgactt atgcaactca gaagtggagt tggacatctc agatggagac aaaggccctg
     2941 ttatgtggca ctaagaaaca tcagtgttgg acaatacatc tctcatctga gctggcatcc
     3001 tccctctctg atggccgtct ccctccacgg gctcacgatg cctcggttcc cacaggtgcc
     3061 cagattcctg gtgtttcccc aagttcgttc tccttcacat tcttcaagac tgtgctctcc
     3121 ctactcagga ccaaagtcct tcgacagtta gcctgactcc tccccttccc cacacatagt
     3181 caggcgctga ctcggtttgc tttatagttc cccagaatcc aactcctttc cgctgccctc
     3241 gcctcagtct aggcttcctc ctacctgtac agttgaaggt tcgccattac tataaacaca
     3301 tctgctccct ctttgatgca cttgccaccc agggggacag cctgtctctt ctctttgaaa
     3361 ctgagctttt caacaaatgc acctgaaagc ctgaggcctc tgtcagaaac atgggttctg
     3421 tcctcccgtt ctttttctta ctttctgtga ctcagatgct tttcagagtc tgctatgaaa
     3481 cctgattgct ggacacggaa acacacacct gtaatctcag gagtctgagg ccagaggatc
     3541 tcactctggg gtcaccctca tagtgagtcc ctgtgttgaa aaaaagagtc atggggctgg
     3601 agagatggct cagtggttaa gagcactgac tgctcttcca gaggtcctga gttcaattcc
     3661 cagcaaccac atggtggctc acaaccatct gtaatgggat ctgatgccct cttctggtgt
     3721 gtctgaagac aactacagtg tacttatata taataaataa ataaatcttt aaaaaagaaa
     3781 gaaaa
//
LOCUS       NM_001438105            3572 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 10, mRNA.
ACCESSION   NM_001438105 XM_063266464
VERSION     NM_001438105.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266464.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1119264.1,
                                           SRR26643296.1165.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-187             JAXUCZ010000001.1  94931143-94931229   c
            188-355             JAXUCZ010000001.1  94930658-94930825   c
            356-483             JAXUCZ010000001.1  94928181-94928308   c
            484-584             JAXUCZ010000001.1  94928000-94928100   c
            585-667             JAXUCZ010000001.1  94926045-94926127   c
            668-822             JAXUCZ010000001.1  94925808-94925962   c
            823-1001            JAXUCZ010000001.1  94923695-94923873   c
            1002-1917           JAXUCZ010000001.1  94922695-94923610   c
            1918-1999           JAXUCZ010000001.1  94922525-94922606   c
            2000-3572           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3572
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            101..187
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2141
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 10;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425034.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <780..1667
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <780..1667
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1887..>2021
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    1887..>2021
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            188..355
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            356..483
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            484..584
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            585..667
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            668..822
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1001
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1917
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1999
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..3572
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag ttttcacctc ccaagacagc
      121 ccttggaaat gttccccaag gtggacaacc ctttagacca tcaagaagcc agaactggag
      181 ccacaaggtc tcaaaagcca caagctccca aggccacagc agccaattct gctgagctgt
      241 ctgaggagtc ctggccatcc agttcaggga ccgcttcccc acccagtacc actgagggac
      301 agagtacctc tccacccctc accttaattg acaacgagga ctcagtggtg gccaagtaca
      361 taaaccggtt ccgcaaagct cagcccacga gccgagagga ccgccagccc gtgggcccaa
      421 ccccagctga cttttggtgg ctacagcctg cgtcttcaga cctcagcagt caccttgcag
      481 caggagctgg tgaacctaca ggaagatctg ccgtgacagg tccatgtccc accgggatgt
      541 ccagtacgtc tctggcttct gtgcctcttc agagagtaaa gcagagtctg aactcttgga
      601 actcggctat gctggagctg gagaccctga gccttcaaag ccgagcggcc aagctgctgg
      661 aacgcagcaa ggcctccctc tcctcctcct cctcctcccc cagtcccaac gaagccagca
      721 gctcctcctt ccccatcagc tctgacggcc tctctccctg ctctgtgacc ttcaatccgg
      781 actccaacaa gagttctagt cccaaagaac ccgtgctggg agcagcccca gtgccatccc
      841 aggccatccc tgcaccccgc ccagcctctg cccaggcaac ccttaagcct gaggaagaca
      901 ttttatacca atggaggcaa cggaggaagc ttgagcagtc tctacaaggt gcaggtgatg
      961 gaacctgggt gttgcctcgg acaccagccc tcactactca gactcctgtc tctgcagtga
     1021 atcttggttc caaggggacc caacctaact gtgctccacc atggggcagt gtggcccagc
     1081 ctcctccccc acaggcattc tatatggaga ggccacctct ttcagggccc tctccacaca
     1141 tctgggcccc cggcacacac ggggttctct gggccccaca ggccaatccc tggatacctc
     1201 ttgggatggt tcctaccaca ctgctaacct ccacccttgc tcccttggcc tccttaccag
     1261 taccacctac ctccacttca gctgccacag cccccatctc tgctccccag gtctccatcc
     1321 cagggccccc agcctctgcc ccacctccct gcacttctgc cccagcttcc accgtcccac
     1381 tacctgacaa cccccaggga ccaaccaccc ctgagttgag tagctctgtc catcccaaga
     1441 agctgagccc caagcctcgc tgtgtgagcg cttcgtctcg tcaggagact actggaccag
     1501 acactgcagc tttcgagagt ccctgttctc agcttagggg ggctctgagc caggtagtga
     1561 cagctcggct gttctccgac agcctggagg atatgcctcc atctgaagca gattcccgga
     1621 aagtcaaggc cacctcctct caagccaaag ttccgccccc tccacctgag tcccggcgtg
     1681 ggtccaagac agagtcccgc aaaagtaaag tcaccctctc agctgaagct ggggatccac
     1741 agccggctac agccccaaag gcatccacac tgtcagaggt ccaatcactt gaattcaaga
     1801 agtctacacc caagaaggga gctggtgacg ccttgactac ggccccgcct gcctcaagcc
     1861 acgccccttc cgaggacttg ctatcccagg ccgctagact tctgcaggct gcggaagact
     1921 ctgacggcag cgagtttccg gaagactctg tgttgcgagt gctaagggct cagagggcag
     1981 aactaaggca gcagaaaagg aatgtggatg cccaattatc cctcctcttg gaccacactg
     2041 aagacccagg attttcatct cctccagcca ggtcaccttc cagttcccca agaatgcggt
     2101 taaggaggga aggagcctcc cttgaggcca gacgaccttg aatcataaac attgtttttc
     2161 ctgggctggg gaggtggctc agtgggtaaa gcacttgcaa gtgtgaagac ccgagtttag
     2221 atccccagaa cccacataaa ggtaactgac aggccagctg gtccatggag acagggtctc
     2281 aatcaaggtg gaaatcaaag accaatctct gaaattctct gacttccaca caagagctgt
     2341 ggggtgtggt gcacataaca caggcacgca cacacaggca cacacacaca cggacgcaca
     2401 catgcgctcg cgcacgcaca cacacacaca cacacacata cacaggcaca cacactaaag
     2461 ttgtccccaa ttaatatttt tccagtttac tgttaatctc taagaaatgg gttgttgtag
     2521 aaaggctgat tgtgctaata aggaaatgta gctcttccct aactactgaa acaaagtttc
     2581 ttctctctag ccctccttcc caccccctct ctctgatatc cctccccctc tctctccccg
     2641 ggagcacatg gctctaggta atgtgggcac ctgacttatg caactcagaa gtggagttgg
     2701 acatctcaga tggagacaaa ggccctgtta tgtggcacta agaaacatca gtgttggaca
     2761 atacatctct catctgagct ggcatcctcc ctctctgatg gccgtctccc tccacgggct
     2821 cacgatgcct cggttcccac aggtgcccag attcctggtg tttccccaag ttcgttctcc
     2881 ttcacattct tcaagactgt gctctcccta ctcaggacca aagtccttcg acagttagcc
     2941 tgactcctcc ccttccccac acatagtcag gcgctgactc ggtttgcttt atagttcccc
     3001 agaatccaac tcctttccgc tgccctcgcc tcagtctagg cttcctccta cctgtacagt
     3061 tgaaggttcg ccattactat aaacacatct gctccctctt tgatgcactt gccacccagg
     3121 gggacagcct gtctcttctc tttgaaactg agcttttcaa caaatgcacc tgaaagcctg
     3181 aggcctctgt cagaaacatg ggttctgtcc tcccgttctt tttcttactt tctgtgactc
     3241 agatgctttt cagagtctgc tatgaaacct gattgctgga cacggaaaca cacacctgta
     3301 atctcaggag tctgaggcca gaggatctca ctctggggtc accctcatag tgagtccctg
     3361 tgttgaaaaa aagagtcatg gggctggaga gatggctcag tggttaagag cactgactgc
     3421 tcttccagag gtcctgagtt caattcccag caaccacatg gtggctcaca accatctgta
     3481 atgggatctg atgccctctt ctggtgtgtc tgaagacaac tacagtgtac ttatatataa
     3541 taaataaata aatctttaaa aaagaaagaa aa
//
LOCUS       NM_001438054            1663 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            3, mRNA.
ACCESSION   NM_001438054
VERSION     NM_001438054.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 1663)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 1663)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 1663)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 1663)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR22582419.1807386.1, SRR21887621.940300.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000001.1  254838799-254839081 c
            284-386             JAXUCZ010000001.1  254829899-254830001 c
            387-431             JAXUCZ010000001.1  254829728-254829772 c
            432-507             JAXUCZ010000001.1  254829533-254829608 c
            508-610             JAXUCZ010000001.1  254829330-254829432 c
            611-783             JAXUCZ010000001.1  254829031-254829203 c
            784-906             JAXUCZ010000001.1  254828414-254828536 c
            907-990             JAXUCZ010000001.1  254828151-254828234 c
            991-1114            JAXUCZ010000001.1  254827934-254828057 c
            1115-1263           JAXUCZ010000001.1  254827574-254827722 c
            1264-1663           JAXUCZ010000001.1  254812800-254813199 c
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1663
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     CDS             259..1287
                     /gene="Ldb1"
                     /note="isoform 3 is encoded by transcript variant 3; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 3"
                     /protein_id="NP_001424983.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQV
                     PKSQLVNI"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
ORIGIN      
        1 acacactccg gggacgcaca cccgcgcgta cacacgcaga ggcagctcgc cttcctgcct
       61 ggcttccttc ctgtttgctc cgcgcctgac aggcccctcg ctgcaggcag gggcggcccg
      121 caccgggcaa aggccgggcc gggccggcgg cgcgggcaac gggggccgcg ggcggcggca
      181 gcggctcatg cccagcctgt ccctgcgagg ggcgggcatc gtgactcggc tgggccccca
      241 gcagcgggcg atgtgaagat gtcagtgggc tgtgcctgtc ctggttgttc ctcaaagtca
      301 ttcaagctgt actccccgaa ggagcccccg aacggcaacg ccttccctcc cttccatccc
      361 ggcaccatgc tggatcggga tgtgggccca actcccatgt acccacctac atacctggag
      421 cctgggatag ggaggcacac gccatatggt aaccagacag actatagaat atttgaactt
      481 aacaaacgac tacagaactg gacagaggag tgtgacaatc tctggtggga cgctttcacg
      541 accgagttct tcgaggatga tgctatgctg accatcactt tctgcctgga ggatggacca
      601 aagagatata ccattggccg gaccctgata ccacgctact tccgaagcat tttcgagggg
      661 ggtgctacgg agctgtatta cgtacttaag caccccaagg aggcattcca cagcaacttc
      721 gtgtccctcg actgtgacca gggcagcatg gtgacccagc atggcaaacc catgtttacc
      781 caggtgtgtg tggaaggccg gttgtacctg gagttcatgt ttgacgacat gatgcggata
      841 aagacatggc acttcagtat ccggcagcac agagagctca tccccaggag tatcctggcc
      901 atgcacgccc aggaccccca gatgttggat cagctctcca aaaacattac ccggtgtggg
      961 ttgtccaatt ccactctcaa ctacctccga ctctgtgtga tactggagcc catgcaggaa
     1021 ctcatgtccc gtcacaagac ctacagcctc agcccccgag actgcctcaa gacctgcctt
     1081 ttccagaagt ggcagcggat ggtagcacct cccgcggagc ctgcacgaca gcagcccagc
     1141 aaacggagga aacggaagat gtcagggggt agcaccatga gctcgggggg cggcaacacc
     1201 aacaacagca acagcaagaa gaagagccca gccagcacct tcgctctctc cagccaggta
     1261 cctaaatccc agctcgtgaa catttgaaga gtgaagctgg cagtgacaag agatgctcac
     1321 caggaggcgc cagtgcctaa gaagatactg aaaccctgta tggaggctcc ttcctgcgga
     1381 gactgaagtc ccgtgccctc taggatctca taaggagttc caggccagct tgggctacaa
     1441 aggagataat tcagcggcta agattgttgt tgctcttgca gagaacctga gctggatttc
     1501 tagtatccgt gtagagtggc tcacaatcaa ttctaacttc agttccaggg aatctcaaat
     1561 gctcttccca cctcggatgg gacatttgca cacacacaca cacacacaca cacacacaca
     1621 cacacacaca caaataaaaa gtaatttttt aagatatctg taa
//
LOCUS       NM_001438034            6872 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2),
            transcript variant 4, mRNA.
ACCESSION   NM_001438034
VERSION     NM_001438034.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6872)
  AUTHORS   Wang,T., Chen,S., Wang,X., Huang,Y., Qiu,J., Fei,Y., Chaulagain,A.,
            Chen,Y., Wang,Y., Lin,L., Yan,B., Wang,Y., Wang,W., Zhao,W. and
            Zhong,Z.
  TITLE     Aberrant PD-1 ligand expression contributes to the myocardial
            inflammatory injury caused by Coxsackievirus B infection
  JOURNAL   Antiviral Res 166, 1-10 (2019)
   PUBMED   30904424
REFERENCE   2  (bases 1 to 6872)
  AUTHORS   He,H., Zhou,Y., Zhou,Y., Zhuang,J., He,X., Wang,S. and Lin,W.
  TITLE     Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation
            through Upregulation of Programmed Cell Death Protein 1 in a Rat
            Spinal Cord Injury Model
  JOURNAL   J Neurotrauma 35 (21), 2591-2603 (2018)
   PUBMED   29665726
REFERENCE   3  (bases 1 to 6872)
  AUTHORS   Wilson,J.K., Zhao,Y., Singer,M., Spencer,J. and Shankar-Hari,M.
  TITLE     Lymphocyte subset expression and serum concentrations of PD-1/PD-L1
            in sepsis - pilot study
  JOURNAL   Crit Care 22 (1), 95 (2018)
   PUBMED   29661225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6872)
  AUTHORS   Singh,A., Mohan,A., Dey,A.B. and Mitra,D.K.
  TITLE     Inhibiting the programmed death 1 pathway rescues Mycobacterium
            tuberculosis-specific interferon gamma-producing T cells from
            apoptosis in patients with pulmonary tuberculosis
  JOURNAL   J Infect Dis 208 (4), 603-615 (2013)
   PUBMED   23661793
REFERENCE   5  (bases 1 to 6872)
  AUTHORS   Cao,J., Liu,F.X. and Yu,M.X.
  TITLE     Expression of programmed death 1 and its ligands in the liver of
            autoimmune hepatitis C57BL/6 mice
  JOURNAL   Chin Med J (Engl) 122 (16), 1941-1946 (2009)
   PUBMED   19781375
REFERENCE   6  (bases 1 to 6872)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
REFERENCE   7  (bases 1 to 6872)
  AUTHORS   Liang,S.C., Greenwald,R.J., Latchman,Y.E., Rosas,L., Satoskar,A.,
            Freeman,G.J. and Sharpe,A.H.
  TITLE     PD-L1 and PD-L2 have distinct roles in regulating host immunity to
            cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 36 (1), 58-64 (2006)
   PUBMED   16358363
REFERENCE   8  (bases 1 to 6872)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   9  (bases 1 to 6872)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 6872)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2443027.1,
                                           SRR26643293.8384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               JAXUCZ010000001.1  236614694-236615345
            653-922             JAXUCZ010000001.1  236617238-236617507
            923-1058            JAXUCZ010000001.1  236620844-236620979
            1059-6872           JAXUCZ010000001.1  236636875-236642688
FEATURES             Location/Qualifiers
     source          1..6872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..6872
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
     exon            1..652
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    619..621
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="upstream in-frame stop codon"
     exon            653..922
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             868..1098
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="isoform 3 is encoded by transcript variant 4; PD-1
                     ligand 2; PDCD1 ligand 2; programmed death ligand 2"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 isoform 3"
                     /protein_id="NP_001424963.1"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
                     /translation="MFWNAHMKELTSAIIDPLSWMEPKVPRTRSLHAFIPACTVALIF
                     LATVIAQRKRLWGKLYSRKRSEPAVLGVGKIQ"
     misc_feature    <868..915
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    <868..915
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    901..912
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    901..912
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            923..1058
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..6872
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagggcca gacccctgtt cttctcaaag tgaacgtgag caacgtacga gaatgcacag
       61 ccttatggga agtgggcatc atatgtcagg tgaaaagtgg tatggccaca tgatttcccc
      121 ctcctctccc tgtttgaggc atctctggat gacttacatt ggagagcatg aataaaaaca
      181 gagaccctct tcttccctgc tctctcctct tactctagaa gcacaggttt tcagttcagg
      241 ccctgtccta gttttatttc tgtggctgtg ataaaaatac cttgaggaaa tgcaacttat
      301 tgttggaggg gttatttggc ttctggttcc accttctatc ctttttgagg ggaaatgacg
      361 gcacaaatca catccagagt caagagcaga gagaaatgaa tgcacgcgca cttgcttgct
      421 tgagttctct acttttatgt agttcaggat cacctgccta ggaaactgca ccgcccatag
      481 tgggccgggt cttcccattt caacttaatt aagacaatag cccatagaga tgcccaccga
      541 ccaacttaat gtggacaatc catcatcaag gtgcttctcc caggtgattc taagttggat
      601 caagttgaca attaaagcta accatcacag accctaaatc tattcataaa agcttcttac
      661 gtgaggatag acactgggat cctagaggtt ccagggacag gggaggtgca gctcatctgc
      721 caggctagag gttaccccct agcagaagtg tcctggcaaa atgtcagtgt tcctgccaac
      781 accagccaca tcaggacccc tgaaggcctc taccaggtca ccagtgttct gcgcctgaag
      841 cctcagccta acagaaactt cagctgcatg ttctggaatg ctcacatgaa ggagcttact
      901 tcagccatca ttgaccctct gagttggatg gaacccaaag tccccagaac acggtcactt
      961 catgctttca tcccggcctg cactgtcgct ctcatcttcc tagccacagt gatagcccag
     1021 agaaagaggc tctggggaaa gctgtattct agaaaaagat ctgagcctgc ggtcttggga
     1081 gttgggaaga tccaatagga aatcctcaag aggcttctgg actcaaagtg agaatctagc
     1141 agagccgcca tttgcacttt tcgaatgctg atcaggagct tgcaggactg ccaagactgc
     1201 cttcccttcc tctcaagact ctctctgaac aaaaacaacc acaatggcac cctagagtcc
     1261 tccctccccc cccccctggg gatcctggac cccagtgaag cccttcctgg tttccagggt
     1321 gaaaacaaaa ggaattgttc ttcctcctcc ccctgcgttc cacggggaga caaggaaatt
     1381 cccagttact aaaatagatt gtgttgataa tagagttttt taatatctgt catttcctct
     1441 ggggatttgg aagtttcaga aagggttttt agtaaacaaa gtcataactg atgtgtttca
     1501 ctgcatccta gaatcctggc agcctctgaa gttctgatta tcaggaagca tttgagtaca
     1561 caactgtgga atttgtttct acttttcttt ttttaaagct gagtcacaca aggcatttgt
     1621 tgtaacctgt gatgtcactg tttattgatc tcttctcttt caactacatt ttttaagacg
     1681 aaacggtgta gggttttgtt gttttgttgg tggtggtagt gtttctcagt ggtatcactt
     1741 taagaaaaaa aaaatcatca tgccagttct ttctttagac ggttcagatg aggagctgta
     1801 atcaccagtc ccccgagcta agccttcttc cctagccttc cgtgtgattt tacgttgaac
     1861 gtttgtgttg ctctgtttct ataactgtaa tgtggtgatg tcattgtcgg ggcatttgat
     1921 gatgagcatt ctggaagtcc ttttgtaaga gaaaaaccct ctgagcccta cgttcagccc
     1981 cactcacaga gacacagaga caggatcaat gcaataagca agaggtttca tgatccagtg
     2041 cactggggtg gccctgtact cagggcagag gcgacctcaa agaacaaagg cccacgccct
     2101 ttatactgtt tttcagggta taggctttag gttacagcat gagttgatta tttctcattg
     2161 gtgggcccta ttaccttttg aattcattgg tggctgccta tcgtcctttg aagtcattgg
     2221 aggcccttgg tggggaagta tatttggcat gcagtggggg tgatgaagga ctcctgctaa
     2281 gggcagctac ctcatttcct ggaacagggt gttatcctaa attccacctg gtgtttggct
     2341 aaggcagcct ttgtctttaa gtttgaatct tacactttca ggttagtgtt tgcgggggag
     2401 agagctcaga atacggaatg gtgctaactt gaagctggag gcatggaatt aactaacctt
     2461 tgggctaccc aaatgtgcac attagctacc atgacatctg taggctagca agctctttac
     2521 ctagtgttta gactgagcag aatttggagt caatgagccc aaaagggtgc aaaattaaga
     2581 tttgaattat gcatcttatt ttatcaccat ctgctcacgc gaaacagaga atacctttga
     2641 agcacaaaaa tgtgatcgtt tatttgaaac ctctgaggta catacactca gatgcccttt
     2701 gcagcaaggt gtctctctaa gattcctgta gggaaagcag ccctactcag taccagacag
     2761 cagccctact cagtaccaga tagcaggaca gagagaaaag tctatgctag acctcccctc
     2821 tcaggtgtgt gattggcagg ccaaaccccg attgccaacc agggtttgtc tgctttatta
     2881 ggaatccagt ggcactatgg atgctgacaa aatgccacca tctcagccct cactgggctg
     2941 ttttctagga tatcaataga gaaagggcca actagatcca gtatcctaaa atcctgagag
     3001 aagaatataa gttagcgtgt ctcactgtga taagtgtccc tctacatgat tgatcacatt
     3061 aatatctaac aattaccaaa tacttactat atgcccaatt ctgttgagca tttcatacac
     3121 accattggat ggaattctct caaaatcctc agaaaaggga attattaata cctccatagg
     3181 caaggagccc ggagcccagc gaggttggtt gggcagtctg gttaaggatg tctgctttgt
     3241 ttagaaggaa gtgaaaaaga acatcaaact catatttatt atagccctgg ttattaatgt
     3301 acctggttac ctgctggatg ggacatcaag gtggactttt ggcacttgca tatgcccggt
     3361 gttatttcgg ctagtcacgg attaatttca cactcactgt ttcccagaca tgtgtagggg
     3421 aagtccaggt tcggaggggc ctaagattcg tactctagct tagttatcta agtctttaaa
     3481 tccaccagct gacctccccg cacattaatt tccctatcta aagagtgagc agtaaccgag
     3541 tgatacctcc tcccttccct tatcaggcac tgttgtgggt agggtgcaat gaatacttga
     3601 taaatatgtg tccgtgtgaa tccccacgtg ccagccgctg tccccaatgc aaaagcagca
     3661 cagcattcag acatctcagg ctgatttatc agcagcggat ttctcctagc cccatgccta
     3721 aagaaacttc cagcctagat atgttgtgta ggttttgtgt cccagaagcc cctacacagg
     3781 cctcaacttc actactggga ttgctcagga aactgtaccc acacagacca cttttctaag
     3841 aatttggcaa acacctttga gtttatgcta ctgtcattga aaacgttatc gtggatgtgg
     3901 agagtgcatg gtcagcacag tgccatggga tttgaagttc ttttaaatgt gcttcctgtt
     3961 tcaaggtatt tggtgagaag aagctgtttc atgacctctt cttaaaatag atccaggtgg
     4021 tgaggtgcaa acagacagca aatggtgttc attttgtaac tcacatgacc acctcactgc
     4081 tacctgtcaa agggtaccta tcctcttaac acatctgaga gtgtttaaag aatgagtctg
     4141 aggcttagca ggtaaaagtg cttgtcatca cacaagcctg atgaccagag ttcaaacctc
     4201 agaacccaca gtggaaggag aagagagaac ccacccctga aagttgttct ctgacctcca
     4261 catctgtgcc atggtgtaca tacacacaca cataatatat acacacatgc acacacataa
     4321 tacatatcca cacatacata catacataca cacacataca cacatacata cacacacata
     4381 catacacaca cataatacat atccacacat acatacatac atacatacac acacatacat
     4441 acacacacat acatacacac ataatatata cccacgcata catacataca tacacacata
     4501 atacatatcc atccatccat ccatacatac atacatacat acatatacac acatacacat
     4561 acatacacac aaacatacat atacacacat atacacacat aatacatacc cacacatata
     4621 tacatacata catatacaca catacacaac acattataca tacccccaca cacattacat
     4681 ataaaagtcg cagtcctgct gcatgtcttt tattactttt aaagtgaata ttaaccaagt
     4741 atttccttgg aaattctaga gcattcctta aggtcaattc ttatccatgg gtttctgttt
     4801 gattggttta gttagttttg ttttgttatg tggagtggtt ttgttatatg gcttccttga
     4861 ggtggttaca ggaacgtgga tttgtgggga aggtgaactt ctcaggagaa ccacttactt
     4921 tctgaggcgc tttatattca cgttgctact ggatgctctt ctagccctgg ggttgcttga
     4981 agcttaattt tgccaacgta acaggttaaa gcaaggacac ttttaagttt tccagttttg
     5041 atccctggct ttgatcctaa gccatcaact cttcctgtga cctcggaatc tgtgtctaat
     5101 ttgtgcttcc cttccctgct ctgcctctag ctaagtgttt tatttactca atgatttaat
     5161 catttagttt ttaagctaca atgtcttcac ctacatatgg acatcctaag aataatactc
     5221 ctctcactgg actgtcgtat gaaaattatg tatacctgat tgaaaaagct gcccaagaaa
     5281 catgcatttc tttccttaac aaatatgaat taagagtgaa taattatgta aattcaagta
     5341 aatgatttta tcaattttct ttgaagttta tgttaaggtt tacctcataa attagaagtt
     5401 tgatactcta ctatctgatt tgtggcttta gattcttcac tgtcttagac taaaatcttt
     5461 tgaacaattg tactttaaaa attttttttc ttttttcttt ttttcggagc tggggaccaa
     5521 acccagggct ttgcacttgc taggcaagcg ctttaccact gagctaaatc cccaactcct
     5581 taaaattatt tttattagtt gagatatatc tcaggaaaat gtactctgat tcacagtaat
     5641 gttggagtag agggagaagc tagattctta ctcgtagtga gtcatgtctg gtttctagtc
     5701 tgtaattcaa gtgaggtagg ctttccgaat gacacagaca ttaattctta gagccacttc
     5761 ccaccagaga ttcccgtggg ttgaaaactt ctgaatgcta gatgatatct tgtcatttct
     5821 attgaaatcg gtaagtccaa ctctgtggta atatttccca ccacaccctg cttacagccc
     5881 tttgctatgt ctcggctcag tgatgcaatt ctcagtgctt cagagaagcc acgactcccc
     5941 gatcctcacg gactcaaggg gcaaggcaag atacacaatt atacatgacc aactctccac
     6001 taaccgcatc tccctgagtc tttaaaggcc ttcagatgtg ttactccata gaccaggtaa
     6061 tgagttagca ttactcatgg aatgtagcct aatcttatgc ccatattcca accactcgac
     6121 cgggcacata caacctttcc cagctgctaa catatttgtt tcacagcttt tgccatcttc
     6181 caagcaacat ccccaaacat aaggacctaa aacaattagt gatggtctac gattttctag
     6241 gttaacaatt tggactgatc taagcagggg ccttacctgg aaactagtct gaaaatggca
     6301 gaagagaagg aaagccggta tgcacaagga ctttgcaagc ctagggctgc atcacgtttt
     6361 ggtttttata ctatttttaa ttattttctc tggatggtgc tttgcctgaa tgtctgtgca
     6421 gcacatgtgt tcagtgcctc agaggccaga agaaggcgtt ggattcccct agaactggag
     6481 ttatagatgc ttgtaagcca tattgtagtg gataggacgt gggtactgtg gaggagaggt
     6541 agtgctttta cccactgatc tatctcccca gccccagttg tatcacattg tctaatgtca
     6601 aagagagcac atatgtgtag cctttggtat gtaaagagag gacatgaagc atgatacttc
     6661 ggaggaccag aaatgctcta acagtctaaa atgttgagtc gaacatatcc cacaagtgac
     6721 agtcagggtt agctgaactg tcccttcagt ggttttctgc tccatccaac ggtagtgtct
     6781 gttactctta gtcaaatacc tttagaatca accccatttt gtgttagtca gtttattcta
     6841 atataaattg aaataaaaat cttgtgactc tc
//
LOCUS       NM_001438043            6701 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus cell migration inducing hyaluronidase 2 (Cemip2),
            transcript variant 2, mRNA.
ACCESSION   NM_001438043 XM_039080169
VERSION     NM_001438043.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6701)
  AUTHORS   Wu,M., Wang,C., Gong,Y., Huang,Y., Jiang,L., Zhang,M., Gao,R. and
            Dang,B.
  TITLE     Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury
  JOURNAL   Int J Mol Med 52 (6) (2023)
   PUBMED   37888730
  REMARK    GeneRIF: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury.
REFERENCE   2  (bases 1 to 6701)
  AUTHORS   Yamamoto,H., Tobisawa,Y., Inubushi,T., Irie,F., Ohyama,C. and
            Yamaguchi,Y.
  TITLE     A mammalian homolog of the zebrafish transmembrane protein 2
            (TMEM2) is the long-sought-after cell-surface hyaluronidase
  JOURNAL   J Biol Chem 292 (18), 7304-7313 (2017)
   PUBMED   28246172
REFERENCE   3  (bases 1 to 6701)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6701)
  AUTHORS   Zhao,Q., Peng,L., Huang,W., Li,Q., Pei,Y., Yuan,P., Zheng,L.,
            Zhang,Y., Deng,J., Zhong,C., Hu,B., Ding,H., Fang,W., Li,R.,
            Liao,Q., Lin,C., Deng,W., Yan,H., Hou,J., Wu,Q., Xu,T., Liu,J.,
            Hu,L., Peng,T., Chen,S., Lai,K.N., Yuen,M.F., Wang,Y., Maini,M.K.,
            Li,C., Li,M., Wang,J., Zhang,X., Sham,P.C., Wang,J., Gao,Z.L. and
            Wang,Y.
  TITLE     Rare inborn errors associated with chronic hepatitis B virus
            infection
  JOURNAL   Hepatology 56 (5), 1661-1670 (2012)
   PUBMED   22610944
REFERENCE   5  (bases 1 to 6701)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 6701)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039080169.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAXUCZ010000001.1  228757460-228757899
            441-578             JAXUCZ010000001.1  228764814-228764951
            579-921             JAXUCZ010000001.1  228772412-228772754
            922-1062            JAXUCZ010000001.1  228777206-228777346
            1063-1624           JAXUCZ010000001.1  228777734-228778295
            1625-1794           JAXUCZ010000001.1  228781911-228782080
            1795-1983           JAXUCZ010000001.1  228785811-228785999
            1984-2153           JAXUCZ010000001.1  228788159-228788328
            2154-2363           JAXUCZ010000001.1  228788815-228789024
            2364-2569           JAXUCZ010000001.1  228789282-228789487
            2570-2639           JAXUCZ010000001.1  228789621-228789690
            2640-2768           JAXUCZ010000001.1  228792749-228792877
            2769-2857           JAXUCZ010000001.1  228796025-228796113
            2858-2989           JAXUCZ010000001.1  228801689-228801820
            2990-3025           JAXUCZ010000001.1  228802972-228803007
            3026-3181           JAXUCZ010000001.1  228803962-228804117
            3182-3359           JAXUCZ010000001.1  228807517-228807694
            3360-3575           JAXUCZ010000001.1  228809465-228809680
            3576-3784           JAXUCZ010000001.1  228812945-228813153
            3785-3967           JAXUCZ010000001.1  228818638-228818820
            3968-4187           JAXUCZ010000001.1  228821174-228821393
            4188-4286           JAXUCZ010000001.1  228824119-228824217
            4287-4441           JAXUCZ010000001.1  228827926-228828080
            4442-4545           JAXUCZ010000001.1  228831248-228831351
            4546-6701           JAXUCZ010000001.1  228831759-228833914
FEATURES             Location/Qualifiers
     source          1..6701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..6701
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="cell migration inducing hyaluronidase 2"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
     exon            1..440
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..578
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..921
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    579..581
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="upstream in-frame stop codon"
     CDS             591..4742
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /EC_number="3.2.1.35"
                     /note="transmembrane protein 2; cell surface
                     hyaluronidase"
                     /codon_start=1
                     /product="inactive cell surface hyaluronidase CEMIP2"
                     /protein_id="NP_001424972.1"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
                     /translation="MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPFRPAPPPKNH
                     ASAKLTSRSQEAPATFAFSPEEQRTPREDRKQKRHKNTFICFAITSFSFFVTLAVILG
                     ISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDMLRLTSDATVNSIVIQDGGLL
                     VFGDDKDGSRNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDEHESMPTFG
                     KKFIGVEAGGTLELHGARRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDT
                     ARVLEHEKFDTHEYHNESRRLQEFLRAQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRL
                     GSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFS
                     VTAYSEWIEGISLSGFRVDIADGVKLHLLDDVSSWGAGDRIVVASTDYSMYQAEELTL
                     LPCPECSRFQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGETEDSCYADNHC
                     QFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHLGRYPVHFHLCGDVDSKGGYRVP
                     TSVNGLSIHHSFSRCITVHGSSGLLIKDTIGFDTLGHCFFLEDGVEQRNILFHNLGLL
                     TKPGTLLPTDRNSSMCTVMRDGVFGNYIPVPTTDCMAVSTFWIAHPNNHLINNAAAGS
                     QDAGIWYLFHKEPTGESSGMQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNS
                     SASDPREYLCLDNSARFRPHQDADPEKPRVAAVIDRLIAFKNNDNGAWVRGGDIIVQN
                     SAFADNGKGLTFASDGSFPSDEGSSQEVSESLFVGESKNYGSQGGQNKYMGTGGIDQK
                     PRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNN
                     VSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYL
                     IRHPNCVSVTKWNAVVCSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAI
                     SPQYQPVVMLEKGYTIHWSGPAPRTTFLYLVNFNKDDWIRVGLCYPSNTSFQVTVGFL
                     QRQNGSLSRIEEYEPAQSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSS
                     QGCERVKIQAATDSKDMSNCMAKAYPQYYKKPSAVKRMPAMLTGFCQGCGTHQMVFSS
                     DPHKSYLPVRFQSPGKAEIQRGEPSVISVNGTDFTFRSAGAFLLIVDACSVPFRLTEK
                     RMFLSADISHLEEYLKASIPPRSIVLLSTRGEIKQMNISDSFVLLGLAKPAHLYNKGS
                     TVFLGFSGNFTPSWTRLFTSPDVQGLGVLEQYLPLQMEEYGCSRTSSVHRRDLELLQQ
                     ALKGL"
     misc_feature    984..1322
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    984..1322
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    1248..1751
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    1248..1751
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    4320..4574
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     misc_feature    4320..4574
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     exon            922..1062
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1624
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1794
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1983
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2153
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2363
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2569
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2639
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2768
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2857
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2989
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3025
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3181
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3359
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3575
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3784
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3967
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4187
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4286
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4441
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4545
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4546..6701
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctcggcc cagccgagcc ggcgcttgtg tggccggagg ctgcttaggg gaccctatcg
       61 agccgcggcg cccgccggac cgggacctgc gcggctcggg aacgcgccct gccgctattg
      121 tctcggggcc gcacaagctc gcgccgcccg gacggcgatt cccctcctct tcctccggga
      181 gggaaggatc caagagcgcc aagccgggct ggctggagga ggtggccggg aaggcggagg
      241 gaggagcgtt actccccggc ccgaactgct tctcctacgg cgtaggctgc cgctgaattc
      301 agaccggcag cgggtcgcgg gttcctggtc atggagagga gatctgcacg cggggactcc
      361 aggagctccg ctcccgctcc cgctcctctg gccatcgctt agacacctga gtagaccgac
      421 gctaggaggg ggaggggaag attaaggagc ctttgagatc tgaaggagga accgcactga
      481 gtacagttgt ggacctgctt ggcttttatt tggggtttgt gactgggggc agctcttact
      541 ctgcagaaag gccgtggcag gacagtgggc tccataagtg acagggtatc atgtatgcgg
      601 ctggttccag gggacactcc cctgctttcc tgcaacctca aaacggaaac ggccaccgct
      661 cacctggtta tgttcccggg aaagtggttc cctttcggcc tgctcctcct ccaaagaacc
      721 acgcctcagc caaactgacc tccaggagcc aagaagcccc agcaaccttt gctttctccc
      781 ccgaggagca gcgaactccg agggaggacc gaaagcagaa gagacacaag aacaccttca
      841 tctgctttgc cataaccagc ttctcgtttt ttgtgacgct cgcagtcatt ttgggaatat
      901 cctccaaata tgctccagat gagaattgtc cagatcaaaa ccctcgtctc aggaactggg
      961 atccaggaca agattctgcg aaacacattg ttatcaagga gggggatatg cttcgcctga
     1021 cctcagatgc tacagtgaat tctatagtca ttcaggatgg aggactgctt gtgtttgggg
     1081 atgacaaaga cggatccagg aatataactt tgaggactcg atacatcctg atacaggatg
     1141 gtggggcgct tcatattgga gcagaaaaat gccgctatcg atccaaagcg acaattacct
     1201 tgtacggcaa gtcagacgaa catgaaagta tgccaacatt tggcaagaag tttattggcg
     1261 tggaggctgg cgggacactg gagttacatg gggctcggag gacatcatgg acgatgctgg
     1321 cgaggactct gcattcctcg ggcttgccct ttggctccta cgccttcgaa aaggacttct
     1381 cccggggcct taatgtgagg gtcattgacc aagacacagc tagagtttta gaacacgaga
     1441 agtttgacac ccatgagtac cacaacgaga gcaggagact tcaggaattt ttgagagctc
     1501 aggatcccgg ccgcattgtt gctattgctg ttggagattc agccgtcaag agcctgttac
     1561 agggaaccat ccagatgatc caggaccggt tgggaagtaa gctgatccaa ggcctgggct
     1621 acaggcaagc ttgggcttta gttggtgtca tcgatggtgg aagttcttcc tgcaatgaat
     1681 ctgtgagaaa ctatgaaaac cacagcactg gtggcaaggc cctagcacaa ggagaattct
     1741 acaccctgga tggtcagaag ttctctgtga cagcttacag tgaatggatt gaaggaattt
     1801 ccctttcggg tttccgggtg gacattgcgg atggagtgaa gcttcacctg ttggacgatg
     1861 tcagcagttg gggagccgga gaccggattg tggttgcgag caccgactat tccatgtacc
     1921 aggcagagga gctgacgctt ctgccctgcc ccgagtgcag ccgttttcag gtcaaagtta
     1981 aagagatccc ccagtacctg cacgttggtg agatcataga cgggatagac atgagagcgg
     2041 aggttggact tctcacccgg aacattgtga tccaaggaga aacggaggac tcatgctacg
     2101 ctgataatca ctgccagttc tttgattatg acacctttgg gggacatgtc atgatagaga
     2161 agaattttac ttcagtccat ctgtcttatg tggagttgaa gcacatgggc cagcagcatc
     2221 tgggacgcta tcctgtgcat tttcacctgt gtggagatgt ggattctaaa ggagggtacc
     2281 gagtgccaac gtctgtgaac ggcctgtcta ttcatcacag cttttcaagg tgcatcactg
     2341 tgcacgggtc cagtggcttg ctcatcaaag acaccattgg attcgacacc ctaggtcatt
     2401 gcttcttttt ggaagatggt gttgaacaga gaaacatttt gttccataac ctggggcttc
     2461 ttaccaagcc gggcactctc ctccccaccg acaggaacag ctccatgtgc accgtcatgc
     2521 gtgatggagt gtttggaaac tacatccccg tgcctaccac agattgtatg gctgtttcaa
     2581 ctttctggat tgcccacccc aacaaccatc tgatcaataa cgcagctgca ggctcacagg
     2641 atgctggaat atggtattta ttccacaagg aaccaactgg ggaatccagt ggaatgcagc
     2701 tcctggagaa gccagaactc acgccactgg gaatatttta taacaacagg gttcattcaa
     2761 attttaaggc tggtttattt gttgacaaag gtgtcaaaac gaccaactcc agtgcctctg
     2821 acccaaggga gtacctgtgt ctggataaca gtgcaaggtt tcggccccat caggatgcag
     2881 accctgaaaa gccacgagtt gcggctgtca tcgacagact cattgctttt aaaaacaatg
     2941 acaatggtgc ctgggtccga ggaggagaca ttattgttca gaattcagca tttgcagata
     3001 acgggaaggg gttgaccttt gccagtgatg ggagcttccc aagcgatgaa gggtccagcc
     3061 aggaagtgtc ggagtccctc tttgtcgggg agagtaagaa ttacggctct cagggtggcc
     3121 agaacaagta catgggcaca gggggaatag accagaagcc tcggacgcta cctaggaaca
     3181 ggacattccc aatccgaggc tttcagattt atgacgggcc tattcatctc acaaagagca
     3241 cgttcaaaaa atatgtgcca actccagaca ggtacagcag cgcaatcggc ttcctcatga
     3301 agaattcctg gcagacaaca cccaggaata acgtctctct tgtgaagttt ggtccacagg
     3361 tctctctgaa cgtcttcttt ggaaagcctg gcccctggtt tgaggattgt gagctggatg
     3421 gtgataagaa ctccatcttc cacgacattg atggctctgt gacaggatac aaggacacct
     3481 atgtaggaag gatggacaac tacctgatcc gccatccaaa ctgtgtcagc gttactaagt
     3541 ggaatgcagt ggtctgcagt gggacctatg cccaggtgta tgttcagacg tggaacacgc
     3601 cgaatcttag catgatcatc acgcgagacg aatacccatc ccacccaatg gtgcttcggg
     3661 gcattaacca gcgggccatc tccccacagt accagcctgt cgtcatgctg gagaagggct
     3721 acaccatcca ctggagtggc ccagcgccac gtaccacttt cttgtacctc gtgaacttca
     3781 acaaggatga ctggatccgg gtcggcctct gttacccgtc caacacgagc tttcaggtga
     3841 ccgtgggctt tctgcagcgg cagaacggct ccttatccag aatcgaggag tacgagcctg
     3901 cgcagtcgat ggaggagctg cagaagaagc cgtctgagag aaaattctac tttgactctg
     3961 gcacagggtt attgtttctg tatctcagag cccacagcca cagagatggc cacagttact
     4021 gttcatctca gggatgtgaa agagtcaaga ttcaggcagc cacagactcc aaagatatga
     4081 gtaactgcat ggccaaagcg tacccacagt attacaagaa accctcggca gtcaagcgca
     4141 tgccagccat gctcaccggg ttctgtcaag gctgtggcac ccaccagatg gtgttcagca
     4201 gtgaccctca caagagctac ctccctgttc gattccagtc ccctgggaaa gcagaaattc
     4261 aacgtggaga accatctgtt atttccgtca atggtactga ctttaccttc cggagtgcag
     4321 gtgccttcct cctcattgtg gatgcctgca gtgtgccctt ccggttgacg gaaaagcgga
     4381 tgttcctttc tgcagacatc agtcacttgg aagaatatct aaaggctagc atccctccaa
     4441 ggtcaatcgt tctcttgagc acaagaggag aaatcaagca gatgaatatc tcggattcat
     4501 tcgtgcttct gggactggcc aagccagcac atctgtacaa caaaggtagt actgtatttt
     4561 tgggattcag cggaaacttc accccatcgt ggactaggct gttcaccagt cctgatgtgc
     4621 agggcctcgg ggtgctcgag cagtatctcc ccctgcagat ggaggaatat gggtgctcca
     4681 ggaccagcag tgtccacaga agggaccttg aactgttaca gcaggctttg aaagggcttt
     4741 aaagacttgc ctgtaattta agtgctggga aagaaaagaa aatgtgaact aacttattta
     4801 atttatggca ttttaagaca acactgttaa cccgatggaa ccattttctt gttttgatac
     4861 agaagggaga gaaagaactc aaagcagttg cttgagtgcc ggtttgtgca ctgtggcgtt
     4921 gtgcaggtgg gaaagaaccc ttttgtcttt gtgaggctgc tgagttcgga gagcagttct
     4981 catgcccctt ctttgataag cccatcacgg gtgctttctg tatagtagga tgcagggagc
     5041 ccaagggctc cccgagctcc tcagaggacg ggctgctgtg gcatttcaga tacttgaagt
     5101 cgaatgctca gtcctgcagc caactccact ggctgccctg ttcagtgatg tctggggctc
     5161 atttctgtac agcccacaag ggttttgtgt gatgccagat ccggttttaa gtaacaactc
     5221 aggcccagca catgtcctcc ttgcctggtc atgtgccctt tttattcact tgtatactga
     5281 ttactttaga gggttcacct ttcaaagagg gaaccatatt gggacaaaag agtttttgaa
     5341 atctttttga tctgtgacca ttgaggaaaa ggaaagaaag gaagaaacag cacaaaacta
     5401 ttacttgctt ccaggtctga ggttggtggg actttttctg cagctttaat ccttaacctg
     5461 tcttgacctt taaaatgcag agctgaagtg atttactttc ctttaaaaga agcaagccac
     5521 ttccaaaacc gtaaactcct gtcatttgaa cttgcacagg aaagctaggt gtagtggtgc
     5581 tcgcctttga tcacagctct ccagaagcag gaggatctct gtgagtttga ggctagcctg
     5641 gtctacacag tgagttccgg gacagccagg gctaagtaga gaaaccctgt ctcaaaacaa
     5701 acaaaacaaa aacaaaacaa aacaaaatcg ccctgcaaca aaaattaact tgcaaaagga
     5761 aacctgtcct tggttttggt tttgtacctg tgttttgttg tgtggaattt ttttttttaa
     5821 gcgtctctgc tcattgtcct accagaaaat cccagagagc tcactgcttg ctactccata
     5881 aatattgtac ccaaggaaag ggatcatgga gtctgtggat atgagcttct ttgtagcctt
     5941 taaaagaggg agtctctctc agtgaatata gctttcaaag acaaggagaa agaactccgg
     6001 gtcgcccagc tctgcttccc ctgggctttt cctcagctag tgcggacaca tgtggcaaag
     6061 gaggctggct ctgcagccaa gagggaagat ggatcagaat gctgctgtgg ggcgcgaagg
     6121 caggtggatg agtagccagg cacttcctgg ctaacagtag caactgagta tagaaaagtt
     6181 catcttcctc catggagggc cgaggctgat gcctgtgcgt tgtgtccagg agacattcta
     6241 gaacagctct gtgacttgtg atactttaca gaacatgcta cctcaaagtg ctgtgacaaa
     6301 ccatgcggac tgtagtgctc acaggacggg cacgtgtctc aatcaaagtt tggttatttg
     6361 tttatctggg ttttttagat gtgggtgttt ttgtttgttt cttttttctt tctttcgtcc
     6421 tgtttttttt tttttttttt gtacagtgag atcttaccta ttaaatatat ttagtgggtc
     6481 atggttcctg aaggtgattg aattgattgt gtgtacgaat atgtgtgtgt gttttgactt
     6541 aaatatattt ggtgtgtgct gttttggagt tccttttata tatatatata tatatatata
     6601 tttggagaat ggatgcaagt ttcaaagcac tcagtttttc tgattttatg tactaataat
     6661 tagggcctaa gttaaataaa taaaaatgtg tgtgcatgta a
//
LOCUS       NM_001438117            2725 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 5, mRNA.
ACCESSION   NM_001438117 XM_039082056
VERSION     NM_001438117.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2725)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2725)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2725)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2725)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039082056.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.2096.1,
                                           SRR26643288.2011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-745             JAXUCZ010000001.1  96115848-96115913   c
            746-928             JAXUCZ010000001.1  96111458-96111640   c
            929-1100            JAXUCZ010000001.1  96111181-96111352   c
            1101-1332           JAXUCZ010000001.1  96109086-96109317   c
            1333-2725           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2725
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1356
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 5 is encoded by transcript variant 5; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 5"
                     /protein_id="NP_001425046.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHRG
                     GRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGE
                     DKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNA
                     ETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFA
                     DFEYRKDNKVAA"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    832..1164
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    832..1164
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..745
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            746..928
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1100
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1332
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2725
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagc tgaagttcac aaagtcccaa ggccagaaaa tgagcaactc
      721 agaaatgaca gcaagaggca agtagttcct ggagttcctt ctgctccaag aagaggacgt
      781 gggggtcatc gaggtggcag gggaagattt ggtattcgtc gagatggtcc aatgaaattt
      841 gagaaagact ttgactttga aagtgcaaat gcacaattta acaaggagga aatcgacaga
      901 gagtttcata ataaacttaa attaaaagaa gataaacttg agaaacaaga gaaacctgta
      961 aacggtgaag acaaaggaga ctcgggagtt gatacccaga acagcgaggg gaatgctgat
     1021 gaggaagatc cccttgggcc caactgctac tacgacaaaa ccaaatcctt cttcgacaac
     1081 atctcttgtg atgataatag agaaaggaga ccaacttggg ctgaagaaag aaggttaaat
     1141 gctgaaactt ttggaatccc acttcgtcca aatcgtggcc gtgggggtta ccgaggcaga
     1201 ggaggccttg gcttccgtgg tggcagagga cgtggtagtg gccgaggagg aaccttcact
     1261 gcccctcgag ggtttcgtgc tggattcaga ggcgctcgtg ggggtaggga gtttgcagat
     1321 tttgaatata ggaaagacaa caaagttgct gcatagtcta caaacaagtc tctgaacata
     1381 ggtgactcct agctcttcat ggtcctggaa agtggttcgg tctttgtgaa gaatgaagaa
     1441 gtgaagttgc tgtctgtctg tcaccagcac tgggttttgt ctgttttctg cttcacgtca
     1501 aagctatact gcagttgctt tggggcagga aggctcgtct taaaacacaa gcataagtgt
     1561 gtgtggagta gcaggttatg attccttgct tagagttgaa ctaaagccag ctaaatggaa
     1621 ttgctaagtg ttttttcttc aatgaaagga tttttcttat cactaattaa ttgtattcgg
     1681 caattacttt gagttgcctg cagataggcc gtgatactgt gttttgagcc acagaaagtt
     1741 ttgtgtgtgt gcgcgcgcgc gcgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtacgtgtgt
     1801 gtcccataat atgaggtagc ttatttcgac acttaattag ggtgctggat ggtagagaat
     1861 tttgtcagtc aactatgtac acacaggtaa atactgtttc ttaggcaaag gtaacttttt
     1921 tatatagttg taaaattcca ttatattcca ttgccaaaga aacattaaga actttgtata
     1981 gctgtataaa aagcaactaa ttttttaaag aataaacgtt ttaaagtcag caaacatacg
     2041 tgtccttgca gaagtcagtg tgctgaggag cagggatatg ggtgggtctt tttccccttg
     2101 ctttccaggc ttaaggtttt ttatttcctt tgtaatgttt ggaacacaaa tgaagatttg
     2161 ataactttat tccattatct aaaaagcata aattattcat gcatagtgta tggacttcgt
     2221 tttgtagcaa atcacaggat ttgttcaaat aacagatatt ttaagtgtgt gaatgtaaat
     2281 aatcatagat gagaatgtac cttgctgtat tttcaaataa gtaaccttct cctttttaag
     2341 acattaagac tcgttgatct atcagttgac ccgctcctcc tgctatgcct ggaattctgt
     2401 tgtggtaatg ctgactcctg ttttccatca aaaagatgga gttttcagaa tcatctggca
     2461 cctgtaaaac atcactaaca tagtgtgtag gcctgcggcc taccgatgac tctgtacacg
     2521 tttgttgcta actgtaaatt actaataaat cttttttgat atttaagcta tagtggaaaa
     2581 agatctggcc actttgtgtt tttaataaag gccatggaat aaagggatcc aaagatttca
     2641 atatttttaa ctatattggc ttttgttaac tttctcaata aaacattgag tagtgataga
     2701 cgtgtgggaa actgcactgt aggag
//
LOCUS       NM_001438062            6418 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 3, mRNA.
ACCESSION   NM_001438062 XM_006231500
VERSION     NM_001438062.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6418)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6418)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6418)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6418)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6418)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6418)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6418)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6418)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6418)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6418)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231500.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.2281.1,
                                           SRR26643296.4646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-1046            JAXUCZ010000001.1  255060666-255060813
            1047-1270           JAXUCZ010000001.1  255061098-255061321
            1271-1439           JAXUCZ010000001.1  255062205-255062373
            1440-1651           JAXUCZ010000001.1  255063221-255063432
            1652-1750           JAXUCZ010000001.1  255063987-255064085
            1751-1945           JAXUCZ010000001.1  255069136-255069330
            1946-2135           JAXUCZ010000001.1  255069541-255069730
            2136-2276           JAXUCZ010000001.1  255069954-255070094
            2277-2365           JAXUCZ010000001.1  255070390-255070478
            2366-2568           JAXUCZ010000001.1  255071464-255071666
            2569-2692           JAXUCZ010000001.1  255072193-255072316
            2693-2818           JAXUCZ010000001.1  255072589-255072714
            2819-2901           JAXUCZ010000001.1  255072981-255073063
            2902-3138           JAXUCZ010000001.1  255073935-255074171
            3139-3232           JAXUCZ010000001.1  255074448-255074541
            3233-3409           JAXUCZ010000001.1  255074797-255074973
            3410-3474           JAXUCZ010000001.1  255075722-255075786
            3475-3598           JAXUCZ010000001.1  255075873-255075996
            3599-3670           JAXUCZ010000001.1  255076149-255076220
            3671-3765           JAXUCZ010000001.1  255076331-255076425
            3766-3919           JAXUCZ010000001.1  255076801-255076954
            3920-4145           JAXUCZ010000001.1  255081461-255081686
            4146-4306           JAXUCZ010000001.1  255082250-255082410
            4307-4553           JAXUCZ010000001.1  255082513-255082759
            4554-4759           JAXUCZ010000001.1  255082874-255083079
            4760-4910           JAXUCZ010000001.1  255085207-255085357
            4911-5041           JAXUCZ010000001.1  255085463-255085593
            5042-5143           JAXUCZ010000001.1  255085758-255085859
            5144-5257           JAXUCZ010000001.1  255086114-255086227
            5258-5438           JAXUCZ010000001.1  255086358-255086538
            5439-5567           JAXUCZ010000001.1  255086830-255086958
            5568-6418           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6418
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5848
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 3 is encoded by transcript variant 3;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 3"
                     /protein_id="NP_001424991.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVMPGSELPTPNGAALSSNLTGGMPFIEAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQAGSPREITTTEPGSTEIGVSDQL
                     DPQQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPRGVRFTQSSQK
                     EGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTL
                     LGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIIT
                     VENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFP
                     VSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTY
                     KSERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPP
                     RFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQW
                     LRENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPV
                     IHRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFR
                     KNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGATPEGI
                     FLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLS
                     DVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKN
                     IMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSG
                     PEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDE
                     ETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGL
                     LRLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGD
                     DWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSD
                     SEVYTDHGRPGKMHRSATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSL
                     TVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQ
                     DKRGKSHKYDSKGNRFKKKPKEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVS
                     LQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGRKIEADSRTLWAHCWCPLLQGI
                     ACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPA
                     DVGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSE
                     AVPESLKNMLLVMDTAEIFHSADARGGSPSALWEITWERIDCFLPHLRDELFKQTVIQ
                     DPMPTEPHSQKPLASTHLTPAAGDPRMPGHPPPPEIPSEVGACDPEKPESTRAASSSS
                     PGSPVASSPSKQSPAPEGPPPLAQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATS
                     PVPLLATPRPTDPIPTSEVN"
     misc_feature    <1547..>3796
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1547..>3796
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2357..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2357..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5447..5839
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5447..5839
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1270
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1439
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1651
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1750
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1945
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2135
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2276
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2365
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2568
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2692
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2818
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2901
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3138
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3232
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3409
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3474
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3598
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3670
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3765
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3919
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4145
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4306
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4553
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4759
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4760..4910
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4911..5041
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5143
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5144..5257
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5438
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5439..5567
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5568..6418
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagct
      901 gaaaatgaga gcaggaggca tgagtgactc atccaagtgg aagaaacaga agcgatcccc
      961 tcgacctcca cgtcatacaa ccaaagtcat gccaggttca gagctgccca ccccaaatgg
     1021 agccgcctta tcctctaacc ttactggtgg catgcccttc attgaggcac ccacatccat
     1081 ctcctctgca agttcagaag ctgcctccac agtggtcagt ccctgtacag atagtggcct
     1141 ggaattatcc tcccaggcta cctccaagga ggacctcacc gacctggagc aagctggctc
     1201 cccaagggag atcaccacca cagagcctgg gagcactgag ataggagttt ctgatcagct
     1261 tgaccctcag caggaagggg cccatgtaga aaaggcccag tcagcatcgg tggaatctat
     1321 ccctgaagtg ctagaggagt gcacatcccc tactgaccat tctgactctg cctctgtcca
     1381 tgacatggat tatgtcaatc ctcggggcgt gcgctttacc cagtcctccc agaaagaagg
     1441 cacagctttg gttccttatg gtcttccttg catccgtgag ctcttccgct tccttatctc
     1501 cctcacaaat ccacatgacc gccataactc tgaggttatg atccacatgg gacttcattt
     1561 gctgacagta gctcttgagt cagcccctgt ggcccagtgc cagaccctct tgggtctcat
     1621 caaggatgag atgtgccgac acttattcca gctactcagc gtagagcggc tgaaccttta
     1681 cgctgcttcc ctacgagtgt gctttttgct ctttgagagc atgcgggaac acctcaagtt
     1741 ccagttggag atgtacatca aaaagctcat ggagattatc actgttgaaa accccaagat
     1801 gccttatgag atgaaggaga tggcgctgga ggccattgtg cagctctggc gcatccccag
     1861 cttcgtcacg gagctctaca tcaactatga ctgtgactac tactgctcca acctcttcga
     1921 agacctcact aagctgctgt ccaagaatgc ctttcctgtg tctggccagc tttatacaac
     1981 acacctgctg tctcttgatg ccctattgac agttattgac agcactgagg ctcattgtca
     2041 ggccaaagtc ctcaacaccc tcaaccagca agagaagaaa gagacagcca gacctggctt
     2101 tgaggcagtg gatggcagcc cagacactta caagtctgag agagcagcca gtgatgggaa
     2161 agccacagga gtgccctcag atgctccagg ccttcatttt tcaagtggag ggtggttgtc
     2221 aacagaacat ggaaagccag ggtgcagtga tctggaggaa gctggtgact ctggggttga
     2281 caaaaagacc accaggaagc cacctcgatt ttcctgtctt ctgccagatc cacgggaact
     2341 aattgaaatt aaaaacaaaa aaaagctgct gatcactggt acagagcagt tcaaccaaaa
     2401 accaaagaag gggatccagt ttctgcagga gaaaggcctc ctcaccatcc caatggataa
     2461 cacagaggta gcccagtggc tccgagaaaa ccctcggcta gacaaaaaaa tgattggaga
     2521 gtttgtgagt gaccgcaaaa acatggacct gttggagagt tttgtgagca ccttcagctt
     2581 ccagggtctg aggcttgatg aggctctccg cctctaccta gaagccttcc gtctgcctgg
     2641 ggaagcgcct gttattcaca ggctgctgga ggtgttcact gagcactgga ggagttgtaa
     2701 tggctcccca tttgctaata gcgatgcctg ctttgccctg gcctatgctg ttatcatgct
     2761 taacactgac caacataacc acaatgttcg caagcaaaat gcacccatga ccctggagga
     2821 gttccgcaaa aacctgaaag gtgtgaatgg aggcaaggac tttgagcaag acatcctgga
     2881 agacatgtac catgccatca agaatgagga aattgtgatg cctgaggaac aaacaggtct
     2941 ggttcgtgag aattatgtgt ggagtgtgct gcttcatcga ggtgctaccc ctgagggcat
     3001 cttccttcgt gtaccccctg gcagctatga tcttgacctc ttcactatga cctggggccc
     3061 cactattgct gctctctctt atgtgttcga taaaagcctc gaggagacca tcatccagaa
     3121 agccatctca ggcttcagga agtgtgccat gatctccgcc cactatggcc tcagcgatgt
     3181 gtttgacaat ctcatcatct ctctgtgcaa attcacagct ctaagtagtg agtctattga
     3241 gaacctgccc agtgtattcg gaagcaaccc taaagcccac attgcagcca agacagtatt
     3301 ccatttggcc catcgtcatg gtgacatcct tcgggagggc tggaagaata tcatggaggc
     3361 catgctgcag ctcttccgag cccaactttt accgaaggct atggtagagg tagaagattt
     3421 tgtggatccc aatggtaaga tctctctaca gcgggaggag acaccatcaa accgaggaga
     3481 gtcaacagtc cttagttttg taagctggct gacactgagt ggtcctgagc agtccagtgt
     3541 ccggggccca tcgacagaga accaagaggc caagcgagta gccttggact gcatcaagca
     3601 atgtgaccca gaaaagatga tcacagaaag caagttcctc cagctggaat ctctgcagga
     3661 gctcatgaag gctctggtct cggtgacacc agatgaagag acatatgatg aagaagatgc
     3721 tgctttctgt ctggagatgc tgctaaggat tgtgttagaa aacagggacc gtgtgggctg
     3781 tgtatggcag actgttcgag atcatctata ccacctgtgt gttcaggcac aagatttctg
     3841 cttccttgtg gagcgagcag tggtagggct gctacgccta gccattcggc tactccgaag
     3901 agaagagatt agtggccagg tcctgctctc tctgcgcatc ttgttactga tgaagcccag
     3961 cgtgctgtcc agagtcagcc accaggtcgc ttatgggctg catgaactcc tcaagaccaa
     4021 tgctgccaac atccactcgg gtgatgactg ggccactctc ttcacattgc tggagtgcat
     4081 tggctcaggc gtgaagcctc cagatgctct acaagccaca gccagggctg atgctcctga
     4141 tgctggagca caatccgaca gtgagctccc atcctaccat caaaatgatg tcagcctaga
     4201 ccgagggtac acttccgact cagaagtcta cactgaccat ggcaggcctg gcaagatgca
     4261 ccgatcagcc acagacgctg acatggccaa cagtggttgg ttagtggtgg ggaaggatga
     4321 cattgataac tccaaaccag cagcaggact cagcaggcca ggcccttcgc ccttggtcaa
     4381 tcagtacagc cttacagtgg gcctggacct gggaccacat gacactaagt ccttgcttaa
     4441 gtgtgtggag tctctgtcct tcattgttcg tgatgctgct cacatcaccc ctgacaactt
     4501 tgaactctgc gtcaagaccc tccgcatctt tgtagaagcc agtctgaatg gtgggtgcaa
     4561 gtcccaggat aaacgtggca agagtcataa atatgacagc aaagggaacc ggttcaagaa
     4621 aaagcccaag gagggctcga tgcttcggcg gccccgggca tccagccagc atgccactcg
     4681 ggctggacac agtgatgaag aggaggacga aggcgtgcct gccagctacc atacggtgtc
     4741 tttacaggtc agtcaggact tgctagacct gatgcacacc ctgcacacac gggcagcctc
     4801 tatctacagt tcatgggcag aggagcaacg ccacctggag acaggtggcc ggaagattga
     4861 agctgactca cgtaccctct gggcccactg ctggtgccct ttattacaag gtatcgcttg
     4921 cttatgctgt gacgcccggc gccaggtgcg gatgcaggcc ctgacatatc tccagcgagc
     4981 ccttctggta catgacctgc aaaagctaga tgccctggaa tgggagtcct gttttaacaa
     5041 ggtgctgttt ccgctactga ccaagctttt agaaaatatc agccctgcgg atgtgggcgg
     5101 gatggaggag acccggatgc gggcttccac actgctctca aaggtcttcc tgcagcacct
     5161 gtccccactg ctgtccctgt ccacctttgc tgccctgtgg ctcaccatcc tggacttcat
     5221 ggacaagtac atgcacgcag gttccagtga cttgctgtca gaagctgtcc ctgagtctct
     5281 gaagaacatg ctccttgtga tggacacagc agagattttc cacagtgcag atgcaagggg
     5341 aggcagcccc tctgctctct gggagatcac ctgggagcgc atcgattgct tcttaccaca
     5401 cctacgtgat gaactcttca agcagactgt catccaggac cccatgccca cagagcctca
     5461 cagtcaaaaa cctctggctt ctactcacct gacgcctgct gctggtgacc ccaggatgcc
     5521 tggccatcca cctcctccag agataccctc agaagtggga gcttgtgacc cggagaagcc
     5581 cgagagcacc agagctgcca gcagcagctc ccctggatcg ccggtggcct ctagccccag
     5641 caaacagagt cctgccccag agggacctcc cccactggcc cagcccccac taatcctaca
     5701 gcccttgacc tccccactgc aggtgggggt accacccatg actttgccca tcatcctcaa
     5761 ccctgcactc attgaggcca cctctccagt gcctctctta gccacgccac gccctacaga
     5821 ccccatcccc acctctgagg tcaactaagg cagccactca gaggtcagga ccattccttc
     5881 ctatcaggca ttcaaggccc tgcttccagt cccaggggcc acagaaatct tcaggcccaa
     5941 agcaagctgc tgttaccact gcttgacagg gggatgacga tgtttatagt ccctgctggg
     6001 atccactcca ggctgcgagg ttcttcctct gccgttcagt cctgaacttc caagctgaga
     6061 gtggatgcag gctgaacctg tagcctctgc ctctggcctg gcagccctgg ggaggcatag
     6121 agccaaccct gctgtgccaa ccctgcagtg cctgccatgt gccccctgcc aggttgggca
     6181 ttaggagcca agcccgacct ctctgcactt tgttcctctc cctatccagt ccatcagtcc
     6241 tgggccactg cctccagttc ttcttccttc attaaatagt tggtcagttt ggagtcgctt
     6301 ggcaccatgg agggtggaca ggtaggactc gatggggggt ctgcccacag gagcatgtac
     6361 atatggaaaa ataacattgg actttttatg atataataaa tgtcttagta ccaacaca
//
LOCUS       NM_001438060            6514 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 1, mRNA.
ACCESSION   NM_001438060 XM_006231497
VERSION     NM_001438060.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6514)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6514)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6514)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6514)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6514)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6514)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6514)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6514)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6514)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6514)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231497.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.4647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-997             JAXUCZ010000001.1  255057982-255058080
            998-1145            JAXUCZ010000001.1  255060666-255060813
            1146-1369           JAXUCZ010000001.1  255061098-255061321
            1370-1535           JAXUCZ010000001.1  255062208-255062373
            1536-1747           JAXUCZ010000001.1  255063221-255063432
            1748-1846           JAXUCZ010000001.1  255063987-255064085
            1847-2041           JAXUCZ010000001.1  255069136-255069330
            2042-2231           JAXUCZ010000001.1  255069541-255069730
            2232-2372           JAXUCZ010000001.1  255069954-255070094
            2373-2461           JAXUCZ010000001.1  255070390-255070478
            2462-2664           JAXUCZ010000001.1  255071464-255071666
            2665-2788           JAXUCZ010000001.1  255072193-255072316
            2789-2914           JAXUCZ010000001.1  255072589-255072714
            2915-2997           JAXUCZ010000001.1  255072981-255073063
            2998-3234           JAXUCZ010000001.1  255073935-255074171
            3235-3328           JAXUCZ010000001.1  255074448-255074541
            3329-3505           JAXUCZ010000001.1  255074797-255074973
            3506-3570           JAXUCZ010000001.1  255075722-255075786
            3571-3694           JAXUCZ010000001.1  255075873-255075996
            3695-3766           JAXUCZ010000001.1  255076149-255076220
            3767-3861           JAXUCZ010000001.1  255076331-255076425
            3862-4015           JAXUCZ010000001.1  255076801-255076954
            4016-4241           JAXUCZ010000001.1  255081461-255081686
            4242-4402           JAXUCZ010000001.1  255082250-255082410
            4403-4649           JAXUCZ010000001.1  255082513-255082759
            4650-4855           JAXUCZ010000001.1  255082874-255083079
            4856-5006           JAXUCZ010000001.1  255085207-255085357
            5007-5137           JAXUCZ010000001.1  255085463-255085593
            5138-5239           JAXUCZ010000001.1  255085758-255085859
            5240-5353           JAXUCZ010000001.1  255086114-255086227
            5354-5534           JAXUCZ010000001.1  255086358-255086538
            5535-5663           JAXUCZ010000001.1  255086830-255086958
            5664-6514           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6514
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5944
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 1 is encoded by transcript variant 1;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 1"
                     /protein_id="NP_001424989.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKISPCL
                     LNTLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKRSPRPPRHTTKV
                     MPGSELPTPNGAALSSNLTGGMPFIEAPTSISSASSEAASTVVSPCTDSGLELSSQAT
                     SKEDLTDLEQAGSPREITTTEPGSTEIGVSDQLDPQEGAHVEKAQSASVESIPEVLEE
                     CTSPTDHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNP
                     HDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSVERLNLYAA
                     SLRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPS
                     FVTELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAH
                     CQAKVLNTLNQQEKKETARPGFEAVDGSPDTYKSERAASDGKATGVPSDAPGLHFSSG
                     GWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPPRFSCLLPDPRELIEIKNKKKLLITGT
                     EQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNMDLLE
                     SFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNGSPFANSDAC
                     FALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKN
                     EEIVMPEEQTGLVRENYVWSVLLHRGATPEGIFLRVPPGSYDLDLFTMTWGPTIAALS
                     YVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPS
                     VFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVD
                     PNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQ
                     CDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRV
                     GCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILLL
                     MKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATA
                     RADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKMHRSATDADMANSG
                     WLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLTVGLDLGPHDTKSLLKCVESLSFIVR
                     DAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRGKSHKYDSKGNRFKKKPKEGSML
                     RRPRASSQHATRAGHSDEEEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWA
                     EEQRHLETGGRKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVH
                     DLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSP
                     LLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAVPESLKNMLLVMDTAEIFHSADARG
                     GSPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPTEPHSQKPLASTHLTPAAGDPR
                     MPGHPPPPEIPSEVGACDPEKPESTRAASSSSPGSPVASSPSKQSPAPEGPPPLAQPP
                     LILQPLTSPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN"
     misc_feature    <1643..>3892
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1643..>3892
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2453..3010
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2453..3010
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5543..5935
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5543..5935
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..997
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1145
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1369
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1535
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1747
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1846
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2041
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2231
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2372
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2461
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2664
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2788
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2914
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..2997
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3234
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3328
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3505
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3570
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3694
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3766
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3861
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..4015
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4241
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4402
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4649
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4855
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..5006
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5007..5137
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5138..5239
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5240..5353
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5534
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5535..5663
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..6514
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagat
      901 ttctccatgt ctcctcaaca cactggagct aagtagtggg gagcagacca aagccctgaa
      961 ccagttagag agggtactac tctttaagaa cctcaagctg aaaatgagag caggaggcat
     1021 gagtgactca tccaagtgga agaaacagaa gcgatcccct cgacctccac gtcatacaac
     1081 caaagtcatg ccaggttcag agctgcccac cccaaatgga gccgccttat cctctaacct
     1141 tactggtggc atgcccttca ttgaggcacc cacatccatc tcctctgcaa gttcagaagc
     1201 tgcctccaca gtggtcagtc cctgtacaga tagtggcctg gaattatcct cccaggctac
     1261 ctccaaggag gacctcaccg acctggagca agctggctcc ccaagggaga tcaccaccac
     1321 agagcctggg agcactgaga taggagtttc tgatcagctt gaccctcagg aaggggccca
     1381 tgtagaaaag gcccagtcag catcggtgga atctatccct gaagtgctag aggagtgcac
     1441 atcccctact gaccattctg actctgcctc tgtccatgac atggattatg tcaatcctcg
     1501 gggcgtgcgc tttacccagt cctcccagaa agaaggcaca gctttggttc cttatggtct
     1561 tccttgcatc cgtgagctct tccgcttcct tatctccctc acaaatccac atgaccgcca
     1621 taactctgag gttatgatcc acatgggact tcatttgctg acagtagctc ttgagtcagc
     1681 ccctgtggcc cagtgccaga ccctcttggg tctcatcaag gatgagatgt gccgacactt
     1741 attccagcta ctcagcgtag agcggctgaa cctttacgct gcttccctac gagtgtgctt
     1801 tttgctcttt gagagcatgc gggaacacct caagttccag ttggagatgt acatcaaaaa
     1861 gctcatggag attatcactg ttgaaaaccc caagatgcct tatgagatga aggagatggc
     1921 gctggaggcc attgtgcagc tctggcgcat ccccagcttc gtcacggagc tctacatcaa
     1981 ctatgactgt gactactact gctccaacct cttcgaagac ctcactaagc tgctgtccaa
     2041 gaatgccttt cctgtgtctg gccagcttta tacaacacac ctgctgtctc ttgatgccct
     2101 attgacagtt attgacagca ctgaggctca ttgtcaggcc aaagtcctca acaccctcaa
     2161 ccagcaagag aagaaagaga cagccagacc tggctttgag gcagtggatg gcagcccaga
     2221 cacttacaag tctgagagag cagccagtga tgggaaagcc acaggagtgc cctcagatgc
     2281 tccaggcctt catttttcaa gtggagggtg gttgtcaaca gaacatggaa agccagggtg
     2341 cagtgatctg gaggaagctg gtgactctgg ggttgacaaa aagaccacca ggaagccacc
     2401 tcgattttcc tgtcttctgc cagatccacg ggaactaatt gaaattaaaa acaaaaaaaa
     2461 gctgctgatc actggtacag agcagttcaa ccaaaaacca aagaagggga tccagtttct
     2521 gcaggagaaa ggcctcctca ccatcccaat ggataacaca gaggtagccc agtggctccg
     2581 agaaaaccct cggctagaca aaaaaatgat tggagagttt gtgagtgacc gcaaaaacat
     2641 ggacctgttg gagagttttg tgagcacctt cagcttccag ggtctgaggc ttgatgaggc
     2701 tctccgcctc tacctagaag ccttccgtct gcctggggaa gcgcctgtta ttcacaggct
     2761 gctggaggtg ttcactgagc actggaggag ttgtaatggc tccccatttg ctaatagcga
     2821 tgcctgcttt gccctggcct atgctgttat catgcttaac actgaccaac ataaccacaa
     2881 tgttcgcaag caaaatgcac ccatgaccct ggaggagttc cgcaaaaacc tgaaaggtgt
     2941 gaatggaggc aaggactttg agcaagacat cctggaagac atgtaccatg ccatcaagaa
     3001 tgaggaaatt gtgatgcctg aggaacaaac aggtctggtt cgtgagaatt atgtgtggag
     3061 tgtgctgctt catcgaggtg ctacccctga gggcatcttc cttcgtgtac cccctggcag
     3121 ctatgatctt gacctcttca ctatgacctg gggccccact attgctgctc tctcttatgt
     3181 gttcgataaa agcctcgagg agaccatcat ccagaaagcc atctcaggct tcaggaagtg
     3241 tgccatgatc tccgcccact atggcctcag cgatgtgttt gacaatctca tcatctctct
     3301 gtgcaaattc acagctctaa gtagtgagtc tattgagaac ctgcccagtg tattcggaag
     3361 caaccctaaa gcccacattg cagccaagac agtattccat ttggcccatc gtcatggtga
     3421 catccttcgg gagggctgga agaatatcat ggaggccatg ctgcagctct tccgagccca
     3481 acttttaccg aaggctatgg tagaggtaga agattttgtg gatcccaatg gtaagatctc
     3541 tctacagcgg gaggagacac catcaaaccg aggagagtca acagtcctta gttttgtaag
     3601 ctggctgaca ctgagtggtc ctgagcagtc cagtgtccgg ggcccatcga cagagaacca
     3661 agaggccaag cgagtagcct tggactgcat caagcaatgt gacccagaaa agatgatcac
     3721 agaaagcaag ttcctccagc tggaatctct gcaggagctc atgaaggctc tggtctcggt
     3781 gacaccagat gaagagacat atgatgaaga agatgctgct ttctgtctgg agatgctgct
     3841 aaggattgtg ttagaaaaca gggaccgtgt gggctgtgta tggcagactg ttcgagatca
     3901 tctataccac ctgtgtgttc aggcacaaga tttctgcttc cttgtggagc gagcagtggt
     3961 agggctgcta cgcctagcca ttcggctact ccgaagagaa gagattagtg gccaggtcct
     4021 gctctctctg cgcatcttgt tactgatgaa gcccagcgtg ctgtccagag tcagccacca
     4081 ggtcgcttat gggctgcatg aactcctcaa gaccaatgct gccaacatcc actcgggtga
     4141 tgactgggcc actctcttca cattgctgga gtgcattggc tcaggcgtga agcctccaga
     4201 tgctctacaa gccacagcca gggctgatgc tcctgatgct ggagcacaat ccgacagtga
     4261 gctcccatcc taccatcaaa atgatgtcag cctagaccga gggtacactt ccgactcaga
     4321 agtctacact gaccatggca ggcctggcaa gatgcaccga tcagccacag acgctgacat
     4381 ggccaacagt ggttggttag tggtggggaa ggatgacatt gataactcca aaccagcagc
     4441 aggactcagc aggccaggcc cttcgccctt ggtcaatcag tacagcctta cagtgggcct
     4501 ggacctggga ccacatgaca ctaagtcctt gcttaagtgt gtggagtctc tgtccttcat
     4561 tgttcgtgat gctgctcaca tcacccctga caactttgaa ctctgcgtca agaccctccg
     4621 catctttgta gaagccagtc tgaatggtgg gtgcaagtcc caggataaac gtggcaagag
     4681 tcataaatat gacagcaaag ggaaccggtt caagaaaaag cccaaggagg gctcgatgct
     4741 tcggcggccc cgggcatcca gccagcatgc cactcgggct ggacacagtg atgaagagga
     4801 ggacgaaggc gtgcctgcca gctaccatac ggtgtcttta caggtcagtc aggacttgct
     4861 agacctgatg cacaccctgc acacacgggc agcctctatc tacagttcat gggcagagga
     4921 gcaacgccac ctggagacag gtggccggaa gattgaagct gactcacgta ccctctgggc
     4981 ccactgctgg tgccctttat tacaaggtat cgcttgctta tgctgtgacg cccggcgcca
     5041 ggtgcggatg caggccctga catatctcca gcgagccctt ctggtacatg acctgcaaaa
     5101 gctagatgcc ctggaatggg agtcctgttt taacaaggtg ctgtttccgc tactgaccaa
     5161 gcttttagaa aatatcagcc ctgcggatgt gggcgggatg gaggagaccc ggatgcgggc
     5221 ttccacactg ctctcaaagg tcttcctgca gcacctgtcc ccactgctgt ccctgtccac
     5281 ctttgctgcc ctgtggctca ccatcctgga cttcatggac aagtacatgc acgcaggttc
     5341 cagtgacttg ctgtcagaag ctgtccctga gtctctgaag aacatgctcc ttgtgatgga
     5401 cacagcagag attttccaca gtgcagatgc aaggggaggc agcccctctg ctctctggga
     5461 gatcacctgg gagcgcatcg attgcttctt accacaccta cgtgatgaac tcttcaagca
     5521 gactgtcatc caggacccca tgcccacaga gcctcacagt caaaaacctc tggcttctac
     5581 tcacctgacg cctgctgctg gtgaccccag gatgcctggc catccacctc ctccagagat
     5641 accctcagaa gtgggagctt gtgacccgga gaagcccgag agcaccagag ctgccagcag
     5701 cagctcccct ggatcgccgg tggcctctag ccccagcaaa cagagtcctg ccccagaggg
     5761 acctccccca ctggcccagc ccccactaat cctacagccc ttgacctccc cactgcaggt
     5821 gggggtacca cccatgactt tgcccatcat cctcaaccct gcactcattg aggccacctc
     5881 tccagtgcct ctcttagcca cgccacgccc tacagacccc atccccacct ctgaggtcaa
     5941 ctaaggcagc cactcagagg tcaggaccat tccttcctat caggcattca aggccctgct
     6001 tccagtccca ggggccacag aaatcttcag gcccaaagca agctgctgtt accactgctt
     6061 gacaggggga tgacgatgtt tatagtccct gctgggatcc actccaggct gcgaggttct
     6121 tcctctgccg ttcagtcctg aacttccaag ctgagagtgg atgcaggctg aacctgtagc
     6181 ctctgcctct ggcctggcag ccctggggag gcatagagcc aaccctgctg tgccaaccct
     6241 gcagtgcctg ccatgtgccc cctgccaggt tgggcattag gagccaagcc cgacctctct
     6301 gcactttgtt cctctcccta tccagtccat cagtcctggg ccactgcctc cagttcttct
     6361 tccttcatta aatagttggt cagtttggag tcgcttggca ccatggaggg tggacaggta
     6421 ggactcgatg gggggtctgc ccacaggagc atgtacatat ggaaaaataa cattggactt
     6481 tttatgatat aataaatgtc ttagtaccaa caca
//
LOCUS       NM_001438031            6531 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus FANCD2 and FANCI associated nuclease 1 (Fan1),
            transcript variant 2, mRNA.
ACCESSION   NM_001438031 XM_039079939
VERSION     NM_001438031.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6531)
  AUTHORS   Wang,R., Persky,N.S., Yoo,B., Ouerfelli,O., Smogorzewska,A.,
            Elledge,S.J. and Pavletich,N.P.
  TITLE     DNA repair. Mechanism of DNA interstrand cross-link processing by
            repair nuclease FAN1
  JOURNAL   Science 346 (6213), 1127-1130 (2014)
   PUBMED   25430771
REFERENCE   2  (bases 1 to 6531)
  AUTHORS   Pennell,S., Declais,A.C., Li,J., Haire,L.F., Berg,W.,
            Saldanha,J.W., Taylor,I.A., Rouse,J., Lilley,D.M. and Smerdon,S.J.
  TITLE     FAN1 activity on asymmetric repair intermediates is mediated by an
            atypical monomeric virus-type replication-repair nuclease domain
  JOURNAL   Cell Rep 8 (1), 84-93 (2014)
   PUBMED   24981866
REFERENCE   3  (bases 1 to 6531)
  AUTHORS   Smogorzewska,A., Desetty,R., Saito,T.T., Schlabach,M., Lach,F.P.,
            Sowa,M.E., Clark,A.B., Kunkel,T.A., Harper,J.W., Colaiacovo,M.P.
            and Elledge,S.J.
  TITLE     A genetic screen identifies FAN1, a Fanconi anemia-associated
            nuclease necessary for DNA interstrand crosslink repair
  JOURNAL   Mol Cell 39 (1), 36-47 (2010)
   PUBMED   20603073
REFERENCE   4  (bases 1 to 6531)
  AUTHORS   Kratz,K., Schopf,B., Kaden,S., Sendoel,A., Eberhard,R.,
            Lademann,C., Cannavo,E., Sartori,A.A., Hengartner,M.O. and
            Jiricny,J.
  TITLE     Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes
            cells to interstrand crosslinking agents
  JOURNAL   Cell 142 (1), 77-88 (2010)
   PUBMED   20603016
REFERENCE   5  (bases 1 to 6531)
  AUTHORS   MacKay,C., Declais,A.C., Lundin,C., Agostinho,A., Deans,A.J.,
            MacArtney,T.J., Hofmann,K., Gartner,A., West,S.C., Helleday,T.,
            Lilley,D.M. and Rouse,J.
  TITLE     Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to
            DNA damage by monoubiquitinated FANCD2
  JOURNAL   Cell 142 (1), 65-76 (2010)
   PUBMED   20603015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039079939.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.524325.1,
                                           SRR26360194.2141613.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000001.1  127356616-127356764 c
            150-1626            JAXUCZ010000001.1  127354959-127356435 c
            1627-1767           JAXUCZ010000001.1  127354186-127354326 c
            1768-1969           JAXUCZ010000001.1  127352212-127352413 c
            1970-2203           JAXUCZ010000001.1  127350814-127351047 c
            2204-2335           JAXUCZ010000001.1  127348369-127348500 c
            2336-2444           JAXUCZ010000001.1  127347044-127347152 c
            2445-2564           JAXUCZ010000001.1  127345747-127345866 c
            2565-2715           JAXUCZ010000001.1  127339932-127340082 c
            2716-2819           JAXUCZ010000001.1  127334257-127334360 c
            2820-3014           JAXUCZ010000001.1  127333568-127333762 c
            3015-3143           JAXUCZ010000001.1  127332787-127332915 c
            3144-6531           JAXUCZ010000001.1  127327098-127330485 c
FEATURES             Location/Qualifiers
     source          1..6531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6531
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="FANCD2 and FANCI associated nuclease 1"
                     /db_xref="GeneID:309256"
                     /db_xref="RGD:1566323"
     exon            1..149
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            150..1626
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    336..338
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="upstream in-frame stop codon"
     CDS             384..3281
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /EC_number="3.1.4.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein MTMR15; myotubularin
                     related protein 15; fanconi-associated nuclease 1;
                     FANCD2/FANCI-associated nuclease 1"
                     /codon_start=1
                     /product="fanconi-associated nuclease 1 isoform 2"
                     /protein_id="NP_001424960.1"
                     /db_xref="GeneID:309256"
                     /db_xref="RGD:1566323"
                     /translation="MMSQKSSPAQKRPRKSLSTGKTTKSQSHSITSYFNSVPPAKLAC
                     SICHKMVPRYDLIRHLDESCANNGEIVQNEPAQAGLINSTVPTSDLPSTPLEDMTPQK
                     LSPPKRRLISAQCGSKLGVRQQTSPYFKKALVCKNQNKLPNQSVEIRSLGSLSSKLSR
                     RYVKAKKSLSKNEGLASHCPPTSPSPPGPSLVDNCPEMDNKDEILNSSQKENIYSCAP
                     LEEETASEQKVKSSKRMGDGSQKASGGEPALTPASPEQAPTLLSSDLTLVNNTDSSSG
                     DALEQEGAGRVGVGVDEQLAACSHEEVQMTVDAEVGTLVSGGAESNSPADNDDDDAST
                     WSNNPELREAGSALKRQRACSPLEQGASCVPSVTAQPQPSHPYYLRSFLVVLQAILEN
                     EEDMKLFDDQEKGVIAKFYQLSASGQKLYVRLFQRKLTWIKVSKLEYEEIASDLTPVV
                     EELKNLGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFLKLAR
                     QRSVYTWGKTQPGIRAVILKRAKDLAGPSLRVCKGPRAVFCRLLLLFSLTDTMEDEEA
                     ACGGQGQLSTVLLVNLGRMEFPQYSISRKTQIFRDREDLIRYAAAAHMLSDISAAMAS
                     GNWEEAKELSQIAKRDWDQLKSHPSLRYHEALPLFLRCFTVGWIYTRISSRAVEVLER
                     LHMYEEAVKELENLLAQKVYCPDSRGRWWDRLALNLHQHLKRLEEVTITGRLCPQHGM
                     GKSVFVIEGGDPTNPTTILCSVEELALDYYRRSGFDQGIHGEGSTFSTLCGLLLWDII
                     FMDGIPDVFRNAYQASPLDLLTDSFFSSREQALEARLQLIHSAPAESLRAWVTEAWQA
                     QQGRAASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNS
                     QSHHCKLVEVKGPSDRLSCKQMIWLDELQKLGADVEVCHVVAVGAKSKGLG"
     misc_feature    1509..3278
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="repair nuclease FAN1; Region: FAN1-like; cd22326"
                     /db_xref="CDD:411730"
     misc_feature    1509..3278
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="repair nuclease FAN1; Region: FAN1-like; cd22326"
                     /db_xref="CDD:411730"
     misc_feature    order(1509..1514,1650..1652,1662..1667,1689..1691,
                     1698..1700,1809..1817,1866..1874,2109..2111,2118..2126,
                     2133..2135,2250..2252,2406..2408,2415..2417,2424..2429,
                     2433..2435,2508..2510,2520..2522,2529..2531,2541..2546,
                     2553..2555,2607..2612,3081..3083,3165..3167,3171..3173,
                     3183..3185)
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411730"
     misc_feature    order(1509..1514,1650..1652,1662..1667,1689..1691,
                     1698..1700,1809..1817,1866..1874,2109..2111,2118..2126,
                     2133..2135,2250..2252,2406..2408,2415..2417,2424..2429,
                     2433..2435,2508..2510,2520..2522,2529..2531,2541..2546,
                     2553..2555,2607..2612,3081..3083,3165..3167,3171..3173,
                     3183..3185)
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411730"
     exon            1627..1767
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1969
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2203
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2335
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2444
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2564
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2715
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2819
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..3014
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3143
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..6531
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgggctc gtggggctgc gcagagcagc tgcctgcctt gtggcccttt gagagcaact
       61 gagccggttc cgctgcagtg agttccggag agtctgagcg agtcagcgtc ctctttttaa
      121 gacgaacggt tcttagaaag gtcctgaaag gagaagttga acgaataacg acatcaaatg
      181 ttaatccact tttattagtt aacggcgaga gtaaaagcaa acctttagga tccttcaccc
      241 agggtggccg ctgtattaac tgatgaggag gtagcaggat ccttcttgtt aattcaagcc
      301 aagtgaatga aagtaaaaca tttcggtcct tcacctgaga ttacctgatt ttattctcgg
      361 gtcgcctact ttttctaata gtcatgatgt cacaaaagag ctcacctgct caaaaaagac
      421 cccgtaaaag cttatctacc ggcaaaacta cgaaaagcca atctcattcc attacttcgt
      481 attttaacag tgtaccacct gctaaacttg catgttcaat ttgtcataaa atggtgccca
      541 ggtatgactt aatccggcac cttgatgagt cttgtgctaa caatggtgaa atcgttcaaa
      601 atgagcctgc tcaggctggt ttaattaact caactgtgcc tacatcagat ttacccagta
      661 ctcctttaga agatatgaca cctcagaagt tatcaccacc aaagagacgt ttaatctctg
      721 cccagtgtgg ttcaaaactg ggcgtgcgac agcagaccag tccctacttt aaaaaagcct
      781 tggtgtgcaa aaatcaaaat aagcttccaa atcagagtgt ggaaatcagg tctttgggaa
      841 gtctgtcatc aaaactgtcc agaaggtacg taaaagctaa aaaatcactc tctaagaacg
      901 aggggctagc cagtcattgc ccaccgactt ctccgtcccc acctggcccc agcctggttg
      961 ataactgtcc agagatggac aacaaagatg agattttaaa cagttcccag aaggaaaaca
     1021 tttactcgtg tgcacctcta gaggaagaga ccgcttcaga acagaaggta aagagcagta
     1081 aaaggatggg agatggaagt cagaaagctt ccggtgggga gccggccctc acgcctgcat
     1141 ccccagagca ggcccccaca ttactgtcct cagacttaac tcttgtcaat aacacggatt
     1201 cctcttcggg agatgctctc gaacaagaag gtgctggaag ggtaggtgta ggggttgatg
     1261 aacagcttgc ggcatgcagc catgaagaag tacaaatgac tgttgatgct gaggtgggaa
     1321 cgctggtgtc agggggggcg gaatcaaaca gtcctgctga caacgacgac gatgacgcat
     1381 ctacatggag taacaaccca gagcttaggg aagctggcag tgccttaaag agacaaaggg
     1441 cttgcagtcc tctggagcag ggcgccagtt gtgttcccag tgtgacagct caaccccaac
     1501 cgagtcaccc gtactacctg aggagcttcc tggtggttct gcaggccatc cttgagaacg
     1561 aagaggacat gaagctcttc gatgaccagg agaagggcgt tatagctaag ttttaccagc
     1621 tgtcagccag tggtcagaag ttgtatgtga ggctcttcca acgtaaatta acctggatta
     1681 aagtgagtaa actggagtat gaagagattg cctcggactt aacccctgtg gttgaagaat
     1741 tgaagaactt aggctttcta cagacagaat ctgagttgca agaactctct gatgtacttg
     1801 aactcctttc tgctcctgag ctgaaagccc tggccaaaac cttccacttg gtgagtcccg
     1861 gtgggcagaa gcagcagctg gtagacgcct tcctcaaact ggccagacag cgctcagtct
     1921 acacttgggg caagactcag cctggaatca gagcggtgat tttaaagaga gctaaagact
     1981 tggctggccc gtcccttcga gtctgtaaag gccctagggc tgtgttttgc cgcctcctgc
     2041 ttctgttctc gttgactgat accatggaag acgaagaagc tgcgtgtggg ggtcaaggtc
     2101 agctgtctac tgtgctattg gtcaatctgg gccgaatgga gtttcctcag tacagcatca
     2161 gccggaagac ccagatcttc agggacagag aggatcttat cagatacgca gccgccgcgc
     2221 acatgctgag tgacatctca gctgccatgg ccagtgggaa ctgggaagaa gctaaggagc
     2281 tttctcagat tgcaaagaga gactgggacc aactgaaaag ccacccttcc ctgagatacc
     2341 acgaggcctt gccactcttt ctgcgctgtt ttactgttgg gtggatctac acaaggattt
     2401 cctctcgggc tgttgaagta ctagagagac ttcacatgta cgaggaagct gtcaaggaac
     2461 ttgaaaacct cctcgctcag aaagtctatt gtcctgacag cagaggccgc tggtgggacc
     2521 gcctggctct taacctgcac cagcacctga agcgtctgga agaggtgacc atcacaggca
     2581 ggctgtgccc acagcatggg atgggcaagt ctgtgtttgt cattgagggt ggagacccca
     2641 ccaaccccac cacaatcctg tgttctgtgg aggaactggc actggactat tacaggcgga
     2701 gtggctttga ccaagggatt cacggagaag ggtccacctt cagcaccctg tgtggcctcc
     2761 tgctgtggga tatcatcttc atggatggaa taccagatgt cttcagaaat gcctaccagg
     2821 cctcccccct ggatttgctc acagacagct tcttctcaag cagggagcag gccctggaag
     2881 ccaggctgca gctgatccac agcgcccctg ctgagagcct gcgggcctgg gtgactgaag
     2941 catggcaggc ccagcaaggc agggcggctt ctctggtcag ctgggatcgc ttcacttccc
     3001 ttcagcaagc tcaggacctt gtctcctgcc tcgggggtcc tgtcctcagc ggtgtgtgca
     3061 ggcgcctggc tgctgacttt cggcactgcc gaggaggcct ccctgatttg gtggtgtgga
     3121 attctcagag ccaccattgc aagctggtgg aagttaaagg ccccagtgat cgcctgtcat
     3181 gtaagcagat gatctggctg gatgaactac aaaagctggg ggcagacgta gaagtatgcc
     3241 atgtggttgc agttggtgct aagagcaaag gtcttggctg aaagatgtca cactggggac
     3301 atctggccat ctactgggac aagatcttca agtggataaa aatgtcacac tgaggacatc
     3361 tggccatcca ctgggataag accttcagtc ggataaaaat gtcacacagg ggacatctgg
     3421 ccatccactg ggacaagact gtcaagagga taaagctatt tgcactgtgt ccactttggc
     3481 ttgcccgaca cctgagatgg gcgggtggac tgttgaaaat gtagaagtct gcatgggagc
     3541 tgtaggagct gactgcctcc atgttgttaa gcttttaaaa aaaaagccag agggaaaatg
     3601 aacatggtgg actttagttg acacttgagc ttctctacta aatgtactgg cagtgcaacc
     3661 cttgaactgg ggttctctca tggttatcca agaagggcag agcccatagg aagtttaatt
     3721 tccttagggg gaaaagtaag aacaaccaaa accaaattcc ttatttaaag ggaggaagga
     3781 tccagagtac ttcaggtgag atatcacaat ccgtatccag cttcgagctt ttggattatg
     3841 tgtgattaaa aacctgtgcc aagatgttag gggaaaaaat gccctcctga ggtactctga
     3901 cttggtcaaa aatgccctcc tgaggtactc tgacttggtc aaaaatgccc tcctgaggta
     3961 ttctgacttg gtcaaaggtt ggtctggagc ctcactctgc tctcagctga ctgtgagatg
     4021 gtttacctca taaaaaaaaa aaaaaagtga aatatcccat tcttgaaagt gaagtccgct
     4081 ctgtactgac cgcgcttcct actgctcacc tcgctgagcc cagtcccagc gctcacagcg
     4141 agacctgtgc tctgccgcgc atgtgccaag gagctgccta tcaggttact tcatgaggcg
     4201 actggctccc gagtgccagg tctagaagtt taaaagccag ggaggtaata tgtgaccgtg
     4261 gctcccatgg tcactaggaa gctgtggggg aggacaggaa tgtagaaact acagtacagt
     4321 tactagagga tggagaaggg ggaggccttc atttagagag tgaaaatgtt tctgctagtc
     4381 aaagcacatt atgtagctgg gagtgggggc tcacacctgt aatcccagca tttgagaggc
     4441 tgaggcagga ggattacctt gagtttaagg tcagaccagg ctacaaagtg agactgtctc
     4501 aaaaaaagga aaagaagctc attatgagtg ctctggccac tctgcactgt ggaacaagca
     4561 gatgataaac acacgggttg atgtgttggg gaggcacagg cactggttcc caggcctagt
     4621 gaagcctaag acccacacag gagggaacag actccgaaat tgacctctga acttcacctt
     4681 gtgtgccaca gtatacacat actcatctac acacaataaa taaaaacgtg tttaagacat
     4741 taacaacact cagtgggctt tgtttaaatt tgtgtgatgt ttggaggtgg gcattgcaat
     4801 aattctattg gcaggtatga aagaaatagc cactctgact cccaaaactg atctcggcgg
     4861 cagtgggggt gaaacaaatt atttcaagtg aggaaggatc tggagtattt cagttgaagt
     4921 gtcagaaata gttttcaaca gcaaatgttt gtatgtatgt atatatatat tacacacaca
     4981 cacacttttt ttaagtgata ccggtttttc tgatcgctta cattaaaaaa taaaatgcag
     5041 ctgtctcaga ttttcatctc ccctctgtgc agaaaggtcc taagaaggag gccctcacag
     5101 gcagatgagg aagagtcgga agccacctgg atccagtgtc tgcagaaaga actttaggag
     5161 ggttcaggca gcatgacaaa accagctgtc tgtccctgcc tgctggcagc tggcttttgc
     5221 ttgattgaca ggggcagatt tggagtaggg ctttaggtca cccatgctgg cctcgaactc
     5281 ctctaccttc actaccaagt gctgggtctc aggattctgc cacacacctg gctagcttat
     5341 cacgcactct ccaccatttg agtttcctcg tcagtcgtcc agtgtgcaga tctgtgtctc
     5401 agtttttaat cgtgtcatgt tttcatgaac ccttgttttt gagttcttcc tatattttgg
     5461 ttcttagtcc gctactggat gtgaagttgg taaggctcct tttccctctc tctaggctgc
     5521 cgctttggac ggcagtgtcc tttgccgtgc ggaagcttct cagtttcatg aggtcccatt
     5581 tgttatattt attgtttgct tgcttatctt ggtaaaccga tgaattttta ttggggttac
     5641 taacagaagt gtgggtgata gaacaaagat gactcacaaa agcagccgta ccccctgaaa
     5701 gcccacctcc cacccaggcg acactcctgg gagctggaac ccgactctgc acagcctggg
     5761 gtcaggcggc tctgtacaga gtctcctctc tgccagcagc cgtttacccc atcttaaagt
     5821 actgcagaca ggattttgag aagcttgtga gcactttccc agtcgtgtgg cattctgtcc
     5881 atttcctgag tcccctgaac ctcctaaggc ccccagaaat gatttgattc tcatatactg
     5941 ctacaccaca ctccatactg ctcacccatc tgtctctcat cagcttcctt cattgaaggt
     6001 ctagcgatga atggtgactc acccagccac tttgcctatt cagagagccg agctcaacac
     6061 aagttattat tattattaag gcacccgtct attcatctta cgatgataca ttcaatattt
     6121 tctctggctt atcatgcacc gatgttaaat gcacttacgg tgaaatcttt agtattcttt
     6181 ttagtatgtt tttgaggtta tctccgttat gtttctaaaa tgtctcttaa cattttattt
     6241 aacataatgg gatattatta ctatgattta aaaataatgc agtattatca gaataacatg
     6301 gataagcctg aaggacatta tgttaaatga tatatataag aaatgaaata tatgagttcc
     6361 tgtttattaa tttttgaact tagtgactgt gttaacagtg ttctgtatca acagaaagcc
     6421 tttgcaaagg agttcaaggc tgttcccaac tttttccaga ctctatgtag aagaacacaa
     6481 ataggtccat acttggcgcc ggagttgtaa aaataaaaaa taaagtaaag t
//
LOCUS       NM_001438103            3788 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 8, mRNA.
ACCESSION   NM_001438103 XM_063266455
VERSION     NM_001438103.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_063266455.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.469754.1,
                                           SRR26360190.2516552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-312             JAXUCZ010000001.1  94931937-94932148   c
            313-403             JAXUCZ010000001.1  94931143-94931233   c
            404-571             JAXUCZ010000001.1  94930658-94930825   c
            572-699             JAXUCZ010000001.1  94928181-94928308   c
            700-800             JAXUCZ010000001.1  94928000-94928100   c
            801-883             JAXUCZ010000001.1  94926045-94926127   c
            884-1038            JAXUCZ010000001.1  94925808-94925962   c
            1039-1217           JAXUCZ010000001.1  94923695-94923873   c
            1218-2133           JAXUCZ010000001.1  94922695-94923610   c
            2134-2215           JAXUCZ010000001.1  94922525-94922606   c
            2216-3788           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3788
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            101..312
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    282..284
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            313..403
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..2357
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 8;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425032.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <996..1883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    2103..>2237
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    2103..>2237
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            404..571
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            572..699
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            700..800
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            801..883
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1038
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1217
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2133
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2215
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..3788
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tgcaaagaag actcaatagt
      121 gtggagaagt ctgtttcctg acattctgat tctgttagcc tggagtggga accgggaaga
      181 gcctacgggt gtgcttgggt ataccaaccc actctggcac atcaagtcac tgcaggacta
      241 ggccagtcct ctcccactga ggccaggcaa ggcagcccag ttaaggaaac gggatccaca
      301 gacaggcagc agtcagtttt cacctcccaa gacagccctt ggaaatgttc cccaaggtgg
      361 acaacccttt agaccatcaa gaagccagaa ctggagccac aaggtctcaa aagccacaag
      421 ctcccaaggc cacagcagcc aattctgctg agctgtctga ggagtcctgg ccatccagtt
      481 cagggaccgc ttccccaccc agtaccactg agggacagag tacctctcca cccctcacct
      541 taattgacaa cgaggactca gtggtggcca agtacataaa ccggttccgc aaagctcagc
      601 ccacgagccg agaggaccgc cagcccgtgg gcccaacccc agctgacttt tggtggctac
      661 agcctgcgtc ttcagacctc agcagtcacc ttgcagcagg agctggtgaa cctacaggaa
      721 gatctgccgt gacaggtcca tgtcccaccg ggatgtccag tacgtctctg gcttctgtgc
      781 ctcttcagag agtaaagcag agtctgaact cttggaactc ggctatgctg gagctggaga
      841 ccctgagcct tcaaagccga gcggccaagc tgctggaacg cagcaaggcc tccctctcct
      901 cctcctcctc ctcccccagt cccaacgaag ccagcagctc ctccttcccc atcagctctg
      961 acggcctctc tccctgctct gtgaccttca atccggactc caacaagagt tctagtccca
     1021 aagaacccgt gctgggagca gccccagtgc catcccaggc catccctgca ccccgcccag
     1081 cctctgccca ggcaaccctt aagcctgagg aagacatttt ataccaatgg aggcaacgga
     1141 ggaagcttga gcagtctcta caaggtgcag gtgatggaac ctgggtgttg cctcggacac
     1201 cagccctcac tactcagact cctgtctctg cagtgaatct tggttccaag gggacccaac
     1261 ctaactgtgc tccaccatgg ggcagtgtgg cccagcctcc tcccccacag gcattctata
     1321 tggagaggcc acctctttca gggccctctc cacacatctg ggcccccggc acacacgggg
     1381 ttctctgggc cccacaggcc aatccctgga tacctcttgg gatggttcct accacactgc
     1441 taacctccac ccttgctccc ttggcctcct taccagtacc acctacctcc acttcagctg
     1501 ccacagcccc catctctgct ccccaggtct ccatcccagg gcccccagcc tctgccccac
     1561 ctccctgcac ttctgcccca gcttccaccg tcccactacc tgacaacccc cagggaccaa
     1621 ccacccctga gttgagtagc tctgtccatc ccaagaagct gagccccaag cctcgctgtg
     1681 tgagcgcttc gtctcgtcag gagactactg gaccagacac tgcagctttc gagagtccct
     1741 gttctcagct taggggggct ctgagccagg tagtgacagc tcggctgttc tccgacagcc
     1801 tggaggatat gcctccatct gaagcagatt cccggaaagt caaggccacc tcctctcaag
     1861 ccaaagttcc gccccctcca cctgagtccc ggcgtgggtc caagacagag tcccgcaaaa
     1921 gtaaagtcac cctctcagct gaagctgggg atccacagcc ggctacagcc ccaaaggcat
     1981 ccacactgtc agaggtccaa tcacttgaat tcaagaagtc tacacccaag aagggagctg
     2041 gtgacgcctt gactacggcc ccgcctgcct caagccacgc cccttccgag gacttgctat
     2101 cccaggccgc tagacttctg caggctgcgg aagactctga cggcagcgag tttccggaag
     2161 actctgtgtt gcgagtgcta agggctcaga gggcagaact aaggcagcag aaaaggaatg
     2221 tggatgccca attatccctc ctcttggacc acactgaaga cccaggattt tcatctcctc
     2281 cagccaggtc accttccagt tccccaagaa tgcggttaag gagggaagga gcctcccttg
     2341 aggccagacg accttgaatc ataaacattg tttttcctgg gctggggagg tggctcagtg
     2401 ggtaaagcac ttgcaagtgt gaagacccga gtttagatcc ccagaaccca cataaaggta
     2461 actgacaggc cagctggtcc atggagacag ggtctcaatc aaggtggaaa tcaaagacca
     2521 atctctgaaa ttctctgact tccacacaag agctgtgggg tgtggtgcac ataacacagg
     2581 cacgcacaca caggcacaca cacacacgga cgcacacatg cgctcgcgca cgcacacaca
     2641 cacacacaca cacatacaca ggcacacaca ctaaagttgt ccccaattaa tatttttcca
     2701 gtttactgtt aatctctaag aaatgggttg ttgtagaaag gctgattgtg ctaataagga
     2761 aatgtagctc ttccctaact actgaaacaa agtttcttct ctctagccct ccttcccacc
     2821 ccctctctct gatatccctc cccctctctc tccccgggag cacatggctc taggtaatgt
     2881 gggcacctga cttatgcaac tcagaagtgg agttggacat ctcagatgga gacaaaggcc
     2941 ctgttatgtg gcactaagaa acatcagtgt tggacaatac atctctcatc tgagctggca
     3001 tcctccctct ctgatggccg tctccctcca cgggctcacg atgcctcggt tcccacaggt
     3061 gcccagattc ctggtgtttc cccaagttcg ttctccttca cattcttcaa gactgtgctc
     3121 tccctactca ggaccaaagt ccttcgacag ttagcctgac tcctcccctt ccccacacat
     3181 agtcaggcgc tgactcggtt tgctttatag ttccccagaa tccaactcct ttccgctgcc
     3241 ctcgcctcag tctaggcttc ctcctacctg tacagttgaa ggttcgccat tactataaac
     3301 acatctgctc cctctttgat gcacttgcca cccaggggga cagcctgtct cttctctttg
     3361 aaactgagct tttcaacaaa tgcacctgaa agcctgaggc ctctgtcaga aacatgggtt
     3421 ctgtcctccc gttctttttc ttactttctg tgactcagat gcttttcaga gtctgctatg
     3481 aaacctgatt gctggacacg gaaacacaca cctgtaatct caggagtctg aggccagagg
     3541 atctcactct ggggtcaccc tcatagtgag tccctgtgtt gaaaaaaaga gtcatggggc
     3601 tggagagatg gctcagtggt taagagcact gactgctctt ccagaggtcc tgagttcaat
     3661 tcccagcaac cacatggtgg ctcacaacca tctgtaatgg gatctgatgc cctcttctgg
     3721 tgtgtctgaa gacaactaca gtgtacttat atataataaa taaataaatc tttaaaaaag
     3781 aaagaaaa
//
LOCUS       NM_001438056            2315 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            5, mRNA.
ACCESSION   NM_001438056
VERSION     NM_001438056.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 2315)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2315)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2315)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.419480.1,
                                           SRR21887621.297554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               JAXUCZ010000001.1  254833121-254833711 c
            592-694             JAXUCZ010000001.1  254829899-254830001 c
            695-739             JAXUCZ010000001.1  254829728-254829772 c
            740-815             JAXUCZ010000001.1  254829533-254829608 c
            816-918             JAXUCZ010000001.1  254829330-254829432 c
            919-1091            JAXUCZ010000001.1  254829031-254829203 c
            1092-1214           JAXUCZ010000001.1  254828414-254828536 c
            1215-1298           JAXUCZ010000001.1  254828151-254828234 c
            1299-1422           JAXUCZ010000001.1  254827934-254828057 c
            1423-1565           JAXUCZ010000001.1  254827580-254827722 c
            1566-2315           JAXUCZ010000001.1  254826138-254826887 c
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2315
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     exon            1..591
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    489..491
                     /gene="Ldb1"
                     /note="upstream in-frame stop codon"
     exon            592..694
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             675..1796
                     /gene="Ldb1"
                     /note="isoform 5 is encoded by transcript variant 5; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 5"
                     /protein_id="NP_001424985.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQN
                     WTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATE
                     LYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKT
                     WHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQE
                     LMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGG
                     NTNNSNSKKKSPASTFALSSQDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGI
                     DDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ"
     misc_feature    774..1379
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    774..1379
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    1566..1652
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     misc_feature    1566..1652
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     exon            695..739
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..815
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..918
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1091
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1214
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1298
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1422
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1565
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..2315
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcggagag aggctcagag agcgagcagg gaggagaggg agggaggagg gagagaaagg
       61 gagaaaggaa ggagcaggcg ggcgctgcgt gtgtctgagt gtgccagtgt gagtgagtgt
      121 gagtgccggg ccctgcctct cccgcctccc ctgcagaggg gcccggtggc ctagggaggg
      181 cgggcgggct gcttggaggc agaggcagcg agaggcggcg gcgggcagag ccgaggagga
      241 ggaggagaga ggaaagagcc gagcagccat tgttgaggga aaccttgcaa acaaagaagg
      301 ctccggactc cccgcggccc cccgcccccc aggccggccc cctggccccc agcccccggc
      361 ccagtggcca ttgtaacttt ccccccgggc tgtggacccc gcggggcggg cggaggctgt
      421 gcatgcgagt ctttgtgcgg cctgcggagt ggagctccca gccagaccgg cctgtcccac
      481 tcgggacatg agctgctgaa gttggctcca ccttagtcct cacccttgcc agggtccctg
      541 aggacttcca ggcgctcccc gcacctcccc tgaccccctc agttctccca ggttgttcct
      601 caaagtcatt caagctgtac tccccgaagg agcccccgaa cggcaacgcc ttccctccct
      661 tccatcccgg caccatgctg gatcgggatg tgggcccaac tcccatgtac ccacctacat
      721 acctggagcc tgggataggg aggcacacgc catatggtaa ccagacagac tatagaatat
      781 ttgaacttaa caaacgacta cagaactgga cagaggagtg tgacaatctc tggtgggacg
      841 ctttcacgac cgagttcttc gaggatgatg ctatgctgac catcactttc tgcctggagg
      901 atggaccaaa gagatatacc attggccgga ccctgatacc acgctacttc cgaagcattt
      961 tcgagggggg tgctacggag ctgtattacg tacttaagca ccccaaggag gcattccaca
     1021 gcaacttcgt gtccctcgac tgtgaccagg gcagcatggt gacccagcat ggcaaaccca
     1081 tgtttaccca ggtgtgtgtg gaaggccggt tgtacctgga gttcatgttt gacgacatga
     1141 tgcggataaa gacatggcac ttcagtatcc ggcagcacag agagctcatc cccaggagta
     1201 tcctggccat gcacgcccag gacccccaga tgttggatca gctctccaaa aacattaccc
     1261 ggtgtgggtt gtccaattcc actctcaact acctccgact ctgtgtgata ctggagccca
     1321 tgcaggaact catgtcccgt cacaagacct acagcctcag cccccgagac tgcctcaaga
     1381 cctgcctttt ccagaagtgg cagcggatgg tagcacctcc cgcggagcct gcacgacagc
     1441 agcccagcaa acggaggaaa cggaagatgt cagggggtag caccatgagc tcggggggcg
     1501 gcaacaccaa caacagcaac agcaagaaga agagcccagc cagcaccttc gctctctcca
     1561 gccaggatgt gatggtggtg ggggagccca ccctgatggg cggggagttc ggggacgagg
     1621 acgagaggct catcactcgg ctggagaaca cccagtttga cgcggccaac ggcattgacg
     1681 acgaggacag ctttaacaac tcccctgcac tgggcgccaa cagcccctgg aacagcaagc
     1741 ctccgtccag ccaagaaagc aaatcggaga accccacgtc acaggcttcc cagtaaaggc
     1801 cctaccacgg ccacccaggt ctctgcctgc tacccctcac agctccaggg agcagaagcc
     1861 agaacgaaga gactgggcgt ctgaaatggg caacctccat ctacccactt cagggaggga
     1921 ctggactcgc tgggggcagg tgccaagatt tgcccccgag ttgccctggg ctgggcctgg
     1981 cccctgcaga gccttttggg ggaagggggt actcatgtgg atgcctatat ggaccctggg
     2041 cttctgagaa atgtcctgac cctcctctcc ccagggcatt tgtccccatt cgtaccccag
     2101 gttctgggta ccccatcttc ctgatttatc cctttgagcc tggggtttat acccacagcc
     2161 cttaggggct aaatgttggg gccttggttg aatgcccttt cccctaggcg gctgtcaaca
     2221 gagggtaaaa ttctgggctc ctcccttttg ccacttaccc agctccaagt ttttaaaaaa
     2281 aaataatatt attaaaaatg taaattaaaa aaaaa
//
LOCUS       NR_199372               1771 bp    RNA     linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 7, non-coding RNA.
ACCESSION   NR_199372 XR_010054316
VERSION     NR_199372.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 1771)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 1771)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 1771)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 1771)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XR_010054316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.1114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  88052773-88053076   c
            305-479             JAXUCZ010000001.1  88045950-88046124   c
            480-645             JAXUCZ010000001.1  88045709-88045874   c
            646-730             JAXUCZ010000001.1  88043417-88043501   c
            731-768             JAXUCZ010000001.1  88042666-88042703   c
            769-1010            JAXUCZ010000001.1  88042312-88042553   c
            1011-1111           JAXUCZ010000001.1  88042068-88042168   c
            1112-1163           JAXUCZ010000001.1  88040749-88040800   c
            1164-1200           JAXUCZ010000001.1  88040554-88040590   c
            1201-1246           JAXUCZ010000001.1  88040283-88040328   c
            1247-1337           JAXUCZ010000001.1  88040092-88040182   c
            1338-1395           JAXUCZ010000001.1  88038970-88039027   c
            1396-1625           JAXUCZ010000001.1  88038630-88038859   c
            1626-1771           JAXUCZ010000001.1  88038026-88038171   c
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1771
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     misc_RNA        1..1771
                     /gene="Vasp"
                     /product="vasodilator-stimulated phosphoprotein,
                     transcript variant 7"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..304
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    300..1433
                     /gene="Vasp"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001108475.2"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            305..479
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            646..730
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            731..768
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1010
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1111
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1163
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1200
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1246
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1337
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1395
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1625
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1771
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtagtaa gagtaaccgc gtaggtgctg ccggctgagg gggtgcgccg gcgaggttcg
       61 gacgctgcac cccgctttcc atcgcagggg atcccagcac atcagagcac cggagggagg
      121 aggcgcctga gcacccgccc gggcccggtc cacgttctcc ccaggaagct ggactctatg
      181 gggcgggacc ccgagagaga ctgagcagaa cctggagcca gccccgcacc cctgcacttc
      241 caatcagggg cgccccggga gcactccccg tgggcgcgcc gcctgccctc tgcgcagcca
      301 tgagcaacga gacggtcatt tgttccagcc gggctactgt gatgctttac gatgacagca
      361 acaaacgatg gcttcctgct ggcaccggtc cccaggcctt tagccgcgtc cagatctacc
      421 acaaccccac tgctaactct ttccgagttg ttggccgcaa gctgcagcct gaccagcagg
      481 tggttatcaa ctgtgccatc attcgaggtg tcaagtacaa tcaggccact cccatattcc
      541 accagtggcg tgatgcccgc caggtctggg gcctcaactt cggcagcaag gaggacgctg
      601 cgcagtttgc gatcggcatg gccaatgccc tggaggcctt ggaaggaggt gggcctcccc
      661 ctgccccagc accccctgcc tggtctaccc agaatggccc ctccccagag gagctggaac
      721 aacagaaaag gcagcctgaa catttggagc gccgggtctc caatgcagga ggcccacctg
      781 ctcccccagc tgggggccca cctccacctc caggacctcc ccctcctccg ggtccccccc
      841 cacccccagg tctgcccccc tcaggggtat ctggggcagg tcatggaaca ggtgtagccc
      901 caccccctgc acccccactc cctacagcac agggccccag tagtgggggt tccggggccc
      961 caggcctggc cgctgccatt gctggagcca aactcaggaa agtgagcaag caggaggagg
     1021 cctctggggg gcccctggcc cccaaagctg agaatagtcg aggcactggt ggggggctta
     1081 tggaagagat gaacgccatg ctggcccgga gaaggaaagc cacacaggtt ggggagaagc
     1141 cccccaaaga cgagtcagcc agtcaggagg agtcagaggc ccgaatccct gcccaaagtg
     1201 aacctgtgcg aagaccctgg gagaagaaca gcacaacctt gccaaggatg aagtcatcct
     1261 cttctgtgac tacctccgag gcccacccct ctgtgcccag ctccagtgat gactccgact
     1321 tggagagggt gaagcaggag cttgtggaag aggtgcggaa ggagctacag aaaatgaaag
     1381 aggaaataat cgaagtcttt gtccaggagc tgaggaagcg gggttctcct tgactacagg
     1441 gacccagaag acccatttct tctttttgta cttcctgcct ggcacctgct ttccctgcct
     1501 caacttgacc aagagttaca caagaatgcg ttctccccta ccagctccca cttggaagat
     1561 tccacagggg tgtggcttcc tggtgccgtg gtcacaccca cgctggctgc tgattggata
     1621 aggaggattt cagggtccag accatttttg ccctccagga agacgaagtg agggggagga
     1681 gaagaggaaa aataggtcct ccgacttcta caccatagct tcttggacac gggccctcgc
     1741 tgaataaatc tgcagttttt ataaatgcaa a
//
LOCUS       NM_001191563            3940 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            1 (Sorcs1), transcript variant 3, mRNA.
ACCESSION   NM_001191563 XM_002728894
VERSION     NM_001191563.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Yau,B., Blood,Z., An,Y., Su,Z. and Kebede,M.A.
  TITLE     Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1
            gene results in alternative processing of the Sorcs1 protein in
            INS1 beta-cells
  JOURNAL   Sci Rep 9 (1), 19466 (2019)
   PUBMED   31857633
  REMARK    GeneRIF: Type 2 diabetes-associated single nucleotide polymorphism
            in Sorcs1 gene results in alternative processing of the Sorcs1
            protein in INS1 beta-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Ribeiro,L.F., Verpoort,B., Nys,J., Vennekens,K.M., Wierda,K.D. and
            de Wit,J.
  TITLE     SorCS1-mediated sorting in dendrites maintains neurexin axonal
            surface polarization required for synaptic function
  JOURNAL   PLoS Biol 17 (10), e3000466 (2019)
   PUBMED   31658245
  REMARK    GeneRIF: SorCS1-mediated sorting in dendritic endosomes controls
            Nrxn axonal surface polarization required for proper synapse
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Lazar,J., O'Meara,C.C., Sarkis,A.B., Prisco,S.Z., Xu,H., Fox,C.S.,
            Chen,M.H., Broeckel,U., Arnett,D.K., Moreno,C., Provoost,A.P. and
            Jacob,H.J.
  TITLE     SORCS1 contributes to the development of renal disease in rats and
            humans
  JOURNAL   Physiol Genomics 45 (16), 720-728 (2013)
   PUBMED   23780848
  REMARK    GeneRIF: The experimental data from the rat combined with
            association results from different ethnic groups indicates a role
            for SORCS1 in maintaining proper renal function.
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002728894.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               JAXUCZ010000001.1  259534929-259535486 c
            559-626             JAXUCZ010000001.1  259355251-259355318 c
            627-726             JAXUCZ010000001.1  259269929-259270028 c
            727-885             JAXUCZ010000001.1  259220306-259220464 c
            886-959             JAXUCZ010000001.1  259199649-259199722 c
            960-1024            JAXUCZ010000001.1  259175137-259175201 c
            1025-1143           JAXUCZ010000001.1  259148966-259149084 c
            1144-1233           JAXUCZ010000001.1  259146699-259146788 c
            1234-1413           JAXUCZ010000001.1  259140159-259140338 c
            1414-1560           JAXUCZ010000001.1  259128292-259128438 c
            1561-1663           JAXUCZ010000001.1  259112543-259112645 c
            1664-1740           JAXUCZ010000001.1  259112203-259112279 c
            1741-1832           JAXUCZ010000001.1  259110150-259110241 c
            1833-1940           JAXUCZ010000001.1  259107925-259108032 c
            1941-2058           JAXUCZ010000001.1  259106215-259106332 c
            2059-2189           JAXUCZ010000001.1  259104606-259104736 c
            2190-2303           JAXUCZ010000001.1  259101597-259101710 c
            2304-2475           JAXUCZ010000001.1  259088686-259088857 c
            2476-2662           JAXUCZ010000001.1  259067695-259067881 c
            2663-2796           JAXUCZ010000001.1  259059499-259059632 c
            2797-2920           JAXUCZ010000001.1  259057964-259058087 c
            2921-3033           JAXUCZ010000001.1  259052351-259052463 c
            3034-3165           JAXUCZ010000001.1  259051331-259051462 c
            3166-3265           JAXUCZ010000001.1  259044613-259044712 c
            3266-3371           JAXUCZ010000001.1  259031690-259031795 c
            3372-3940           JAXUCZ010000001.1  259029432-259030000 c
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..3940
                     /gene="Sorcs1"
                     /note="sortilin-related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
     CDS             1..3507
                     /gene="Sorcs1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; VPS10 domain-containing receptor SorCS1; VPS10
                     domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1 isoform
                     3 precursor"
                     /protein_id="NP_001178492.1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
                     /translation="MGKVGAGDGSSAALSALLTGAGLLMLLAPGICSSLSCCPPQHPS
                     STPRWTLTPRGFSYPGPLGRAPATPPPLFMRPLFAVAPGDRALFLERAGGSRVSVATA
                     SRSGRRRRSGMDPEKTEPGEGTSRSRRDMLRDGGQQGPGTGARDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNRFYWSVLGSNKEPDLVHL
                     EARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYV
                     SYRRNPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     ADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELSDSDI
                     SMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGTYAGAMESEPCVCTEADFDCDYGYERHSSG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPT
                     AAELFVLPYQDGARENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALTSPPSPSTQPGDSSLRLQ
                     RPRQATPPSSPKRGSAGAQFAI"
     sig_peptide     1..99
                     /gene="Sorcs1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    586..2379
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    586..2379
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    2419..2640
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2419..2640
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2506..>2919
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     misc_feature    2506..>2919
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     exon            1..558
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..626
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..726
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..885
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..959
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1024
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1143
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1233
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1413
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1560
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1663
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1740
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1832
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1940
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2058
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2189
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2303
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2475
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2662
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2796
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2920
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3033
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3165
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3265
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3371
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3940
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaaaag ttggcgccgg ggacggctcc tcggccgcgc ttagcgcgct cctaacggga
       61 gccgggcttc tgatgctctt agcccctggc atctgcagca gcctttcttg ctgccctccg
      121 caacacccta gctcgacccc acgctggacc cttaccccaa gaggcttttc ttaccccgga
      181 ccgctgggtc gggctcctgc cacgcccccg cccctcttca tgagacccct gttcgcagtg
      241 gcccccgggg accgggcgct gtttctggag cgagctgggg gcagcagggt gtcagtggcg
      301 accgcttcac gctctggccg taggagacgg agtggaatgg atcctgagaa gactgaaccc
      361 ggagagggta cgagtcggag ccgccgggac atgctaaggg atggagggca gcaggggcct
      421 gggactggcg cgcgggaccc ggacaaagcc actcgcttcc ggatggagga gctgagattg
      481 accagcacca catttgcgct gactggagac tcggcacaca accaagctat ggtccactgg
      541 tctggccaca acagcagcgt gattctcatt ttgacaaagc tctatgacta taacctggga
      601 agcatcactg agagctcgct ttggaggtca accgattatg ggacaaccta cgagaagctg
      661 aatgataaag tggggttgaa gaccattttg agctatctct atgtgtgccc aaccaacaag
      721 cgtaagatta tgctactcac ggacccggag attgagagca gtttgttgat cagctcagat
      781 gaaggggcaa cctatcaaaa gtaccggctc aacttttaca tccagagttt gcttttccat
      841 ccgaagcaag aagactggat cctggcctac agtcaagacc aaaagttata cagctctgct
      901 gagtttggca gaagatggca gcttatccag gaagcagtgg tacccaatag gttttactgg
      961 tctgtgctgg ggtcgaacaa agaaccagac cttgtgcatc tcgaggccag gaccgtagat
     1021 ggtcactcca tatacttaac ttgtcggatg caaaactgca ctgaagccaa cagaaataaa
     1081 cctttcccag gatacattga cccggattct ttgattgttc aggatgatta tgtgtttgtt
     1141 cagctcacat caggaggaag accacattac tatgtgtcct accgaagaaa cccatttgca
     1201 caaatgaaac ttccgaaata tgctttgccc aaggatatgc atgtcatcag tacggatgag
     1261 aatcaggtgt ttgcagcagt tcaagaatgg aaccagaatg acacctacaa cctgtacatc
     1321 tcagacacac gcggggtcta cttcacgctg gccttggaga acgtgcagag cagcagaggc
     1381 cctgaaggca atgtcatgat tgacctttat gaggtagcag ggataaaggg aatgttcttg
     1441 gctaacaaga agattgacaa ccaagtgaag actttcatca cttacaacaa aggcagagac
     1501 tggcgtttgc tgcaggctcc agatgcagat ctaagggggg accctgtgca ctgtttgctg
     1561 ccctactgtt cactacacct tcatctcaaa gtttctgaga atccctacac atctgggatc
     1621 attgccagca gagacacagc cccaagtatt atagttgcat caggtaacat aggctctgag
     1681 ttgtcagaca gcgacatcag catgtttgta tcatcagatg cagggaacac ttggaggcag
     1741 atttttgaag aagagcacag cattttgtac cttgatcaag ggggagtcct ggttgctatg
     1801 aaacacacat ctctcccaat tcggcacctg tggttgagtt ttgatgaagg gaggtcttgg
     1861 agcaaataca gttttacatc cattccactt tttgtggatg gagtcctggg ggagcctgga
     1921 gaagagacac taatcatgac agtgtttgga cacttcagtc atcgttctga gtggcagctg
     1981 gtcaaagtgg attacaagtc catttttgac agacgctgtg ctgaagaaga ctacagaccc
     2041 tggcagttac atagccaggg ggaagcatgc atcatgggag ccaagaggat ctataagaag
     2101 cgaaaatctg agcgcaagtg tatgcaaggg acgtatgcag gagcgatgga gtctgagcct
     2161 tgtgtgtgta cagaggcgga ctttgactgt gactatggct acgagagaca tagtagtgga
     2221 caatgcctac cagcattttg gttcaacccg tcctcactgt caaaagactg cagcttggga
     2281 cagagttacc tcaacagcac tgggtacagg aaggtggtct ccaataactg cacggacgga
     2341 gtgagggaac agtacaccgc caaaccacag aagtgtccag ggaaggcccc tcgtgggcta
     2401 cggattgtca ctgcagatgg gaaactgaca gcagaacagg ggcacaatgt cactctcatg
     2461 gtgcagttgg aagaggggga tgtacagcgg acactcatcc aagtggactt tggagatggc
     2521 attgcggtgt cttatgtcaa cctcagctcg atggaagacg gaatcaagca tgtatatcag
     2581 aatgtgggca ttttccgagt gaccgtgcag gtggacaaca gtctggggtc tgacagcgcc
     2641 gtcctgtact tacatgtaac ttgtcccctg gaacatgtgc acctgtccct tccttttgtc
     2701 acaacaaaga acaaagaggt caacgcaact gccgtgctgt ggcccagcca agtgggcact
     2761 ctcacttacg tgtggtggta tgggaacaac acagagcccc tgatcacctt ggagggcagc
     2821 atatcattca agtttacttc tgaaggaatg aacactatca cggtacaggt ctcagctggg
     2881 aatgccatac tgcaagacac taagaccatt gcggtatacg aggaattccg ctctcttcgc
     2941 ttggcttttt ctccaaactt ggatgactac aaccctgaca tcccggagtg gaggagggac
     3001 atcagccgag taatcaaaaa gtctctggtg gaagccacag ggattcccag ccagcatatc
     3061 ctggtggcag tgttacctgg cttacccact gctgctgagc tctttgtttt gccctatcaa
     3121 gatggagcta gagaaaacaa aaggtcccca gaggacctgg agcagatatc tgaagttcta
     3181 atccacaaac tcaaccaaaa cttggtgcac tttgagctga agcctggggt ccaagttctt
     3241 gtccacgcag ctcacctaac agcagccccc ctggtggacc tcactcctac ccacagcgga
     3301 tctgccatgc tgatgttgct ctcagtggtg tttgtggggt tggccgtgtt cgtcatctac
     3361 aagtttaaaa ggagagtagc tttaacctcc cctccctccc cttctactca acctggggac
     3421 tcatctctcc gattgcaaag accaagacaa gccacaccac cttcatcgcc aaagcgggga
     3481 tctgctgggg cacaatttgc aatctaagga aaacccccaa aggctacagg agacctgctg
     3541 atcagaaaag aatttcgctc ttgtcaagta catcatcctt catgaccact aactttgttt
     3601 tttttttttt cttcttctgt tgttctgttt cctatttcgc caggaagtat ttccatagtt
     3661 gctgagaatc aaagcacaaa agaaatccct acctatgtaa atgtttgaat ggaggacgcc
     3721 agtaaaaaca aacaaacaaa aagtaaataa aaataaaaac aatcaaaatc caaaataaca
     3781 agtaaacact ctcactgcat cggaactttt aaattcttca gacacagaca acaagggttt
     3841 ttagctttaa gcctgtgcat gtggacaata ctttgagaac gtgtttggag gggcagtgta
     3901 caggtgctct attttaatgg aaaacactcc cctcctttct
//
LOCUS       NM_001107582            1620 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2),
            transcript variant 2, mRNA.
ACCESSION   NM_001107582 XM_001079586 XM_219777
VERSION     NM_001107582.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Wang,T., Chen,S., Wang,X., Huang,Y., Qiu,J., Fei,Y., Chaulagain,A.,
            Chen,Y., Wang,Y., Lin,L., Yan,B., Wang,Y., Wang,W., Zhao,W. and
            Zhong,Z.
  TITLE     Aberrant PD-1 ligand expression contributes to the myocardial
            inflammatory injury caused by Coxsackievirus B infection
  JOURNAL   Antiviral Res 166, 1-10 (2019)
   PUBMED   30904424
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   He,H., Zhou,Y., Zhou,Y., Zhuang,J., He,X., Wang,S. and Lin,W.
  TITLE     Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation
            through Upregulation of Programmed Cell Death Protein 1 in a Rat
            Spinal Cord Injury Model
  JOURNAL   J Neurotrauma 35 (21), 2591-2603 (2018)
   PUBMED   29665726
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Wilson,J.K., Zhao,Y., Singer,M., Spencer,J. and Shankar-Hari,M.
  TITLE     Lymphocyte subset expression and serum concentrations of PD-1/PD-L1
            in sepsis - pilot study
  JOURNAL   Crit Care 22 (1), 95 (2018)
   PUBMED   29661225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Singh,A., Mohan,A., Dey,A.B. and Mitra,D.K.
  TITLE     Inhibiting the programmed death 1 pathway rescues Mycobacterium
            tuberculosis-specific interferon gamma-producing T cells from
            apoptosis in patients with pulmonary tuberculosis
  JOURNAL   J Infect Dis 208 (4), 603-615 (2013)
   PUBMED   23661793
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Cao,J., Liu,F.X. and Yu,M.X.
  TITLE     Expression of programmed death 1 and its ligands in the liver of
            autoimmune hepatitis C57BL/6 mice
  JOURNAL   Chin Med J (Engl) 122 (16), 1941-1946 (2009)
   PUBMED   19781375
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Liang,S.C., Greenwald,R.J., Latchman,Y.E., Rosas,L., Satoskar,A.,
            Freeman,G.J. and Sharpe,A.H.
  TITLE     PD-L1 and PD-L2 have distinct roles in regulating host immunity to
            cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 36 (1), 58-64 (2006)
   PUBMED   16358363
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Mar 29, 2024 this sequence version replaced NM_001107582.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000001.1  236572497-236572720
            225-292             JAXUCZ010000001.1  236591456-236591523
            293-598             JAXUCZ010000001.1  236604073-236604378
            599-868             JAXUCZ010000001.1  236617238-236617507
            869-1004            JAXUCZ010000001.1  236620844-236620979
            1005-1620           JAXUCZ010000001.1  236636875-236637490
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1620
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
     exon            1..224
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    214..216
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="upstream in-frame stop codon"
     exon            225..292
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1044
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; PD-1 ligand 2; PDCD1 ligand 2; programmed death
                     ligand 2"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 isoform 1
                     precursor"
                     /protein_id="NP_001101052.2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
                     /translation="MLLLLLILNLSSQLHHIAALFTVTAPKEVYTVDFGSSVSLECDF
                     DRRECTELEGIRASLQKVENDTSSQSQRATLLEELLPLGKASFHIPSVQVRDSGQYRC
                     LVICGAAWDYKYLTVKVKASYVRIDTGILEVPGTGEVQLICQARGYPLAEVSWQNVSV
                     PANTSHIRTPEGLYQVTSVLRLKPQPNRNFSCMFWNAHMKELTSAIIDPLSWMEPKVP
                     RTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKRSEPAVLGVGKIQ"
     sig_peptide     238..294
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    295..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin Variable (IgV) domain of Programmed
                     death ligand 2 (PD-L2); Region: IgV_PD-L2; cd20983"
                     /db_xref="CDD:409575"
     misc_feature    295..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin Variable (IgV) domain of Programmed
                     death ligand 2 (PD-L2); Region: IgV_PD-L2; cd20983"
                     /db_xref="CDD:409575"
     misc_feature    order(295..303,310..312,319..321,403..405,415..417,
                     436..438,538..540,544..546,550..552,556..567,571..579)
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Receptor-Ligand Binding Site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409575"
     misc_feature    order(295..303,310..312,319..321,403..405,415..417,
                     436..438,538..540,544..546,550..552,556..567,571..579)
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Receptor-Ligand Binding Site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409575"
     misc_feature    295..366
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409575"
     misc_feature    295..366
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409575"
     misc_feature    301..312
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409575"
     misc_feature    301..312
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409575"
     misc_feature    319..333
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409575"
     misc_feature    319..333
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409575"
     misc_feature    340..366
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409575"
     misc_feature    340..366
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409575"
     misc_feature    367..402
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409575"
     misc_feature    367..402
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409575"
     misc_feature    400..420
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409575"
     misc_feature    400..420
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409575"
     misc_feature    403..426
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409575"
     misc_feature    403..426
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409575"
     misc_feature    427..450
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409575"
     misc_feature    427..450
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409575"
     misc_feature    433..444
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409575"
     misc_feature    433..444
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409575"
     misc_feature    451..549
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409575"
     misc_feature    451..549
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409575"
     misc_feature    451..465
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409575"
     misc_feature    451..465
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409575"
     misc_feature    487..510
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409575"
     misc_feature    487..510
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409575"
     misc_feature    520..552
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409575"
     misc_feature    520..552
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409575"
     misc_feature    550..561
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409575"
     misc_feature    550..561
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409575"
     misc_feature    559..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409575"
     misc_feature    559..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409575"
     misc_feature    565..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409575"
     misc_feature    565..594
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409575"
     misc_feature    616..861
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    616..861
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    652..666
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    652..666
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    691..705
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    691..705
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    769..783
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    769..783
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    802..819
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    802..819
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    847..858
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    847..858
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            293..598
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..868
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1004
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1620
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accacatctt ttgttccccc ttgttggtta tatcctaatg tcaaatgtgg gcataccttt
       61 gtggcgcccc cctgtcttcc aaccagaggg gatgcactgg ctgctcctgt tgtggacagg
      121 tttggttggt ggtgtaattg gcttctgagg aacctgatac aaagagtgac tatgtgtagc
      181 cttttctctg tgtctttgtc tgacgagttg tgttgagtcc tgatattgat acagaccatg
      241 ctgctcctgc tgctgatact gaacctgagc tcgcaacttc atcacatagc agctttattc
      301 acggtgacag cccctaagga ggtgtacacc gtagacttcg gcagcagtgt gagcctggag
      361 tgtgattttg accgcagaga atgcaccgag ctagaaggaa taagagccag tttgcagaag
      421 gtagaaaacg atacttcttc acaaagtcaa agagccaccc tgctggaaga gctgcttccc
      481 ctggggaagg cttcgttcca catccccagt gtccaagtga gagattcagg gcagtaccgt
      541 tgtctggtca tctgcggggc cgcctgggac tacaagtacc tgacggtgaa agtcaaagct
      601 tcttacgtga ggatagacac tgggatccta gaggttccag ggacagggga ggtgcagctc
      661 atctgccagg ctagaggtta ccccctagca gaagtgtcct ggcaaaatgt cagtgttcct
      721 gccaacacca gccacatcag gacccctgaa ggcctctacc aggtcaccag tgttctgcgc
      781 ctgaagcctc agcctaacag aaacttcagc tgcatgttct ggaatgctca catgaaggag
      841 cttacttcag ccatcattga ccctctgagt tggatggaac ccaaagtccc cagaacacgg
      901 tcacttcatg ctttcatccc ggcctgcact gtcgctctca tcttcctagc cacagtgata
      961 gcccagagaa agaggctctg gggaaagctg tattctagaa aaagatctga gcctgcggtc
     1021 ttgggagttg ggaagatcca ataggaaatc ctcaagaggc ttctggactc aaagtgagaa
     1081 tctagcagag ccgccatttg cacttttcga atgctgatca ggagcttgca ggactgccaa
     1141 gactgccttc ccttcctctc aagactctct ctgaacaaaa acaaccacaa tggcacccta
     1201 gagtcctccc tccccccccc cctggggatc ctggacccca gtgaagccct tcctggtttc
     1261 cagggtgaaa acaaaaggaa ttgttcttcc tcctccccct gcgttccacg gggagacaag
     1321 gaaattccca gttactaaaa tagattgtgt tgataataga gttttttaat atctgtcatt
     1381 tcctctgggg atttggaagt ttcagaaagg gtttttagta aacaaagtca taactgatgt
     1441 gtttcactgc atcctagaat cctggcagcc tctgaagttc tgattatcag gaagcatttg
     1501 agtacacaac tgtggaattt gtttctactt ttcttttttt aaagctgagt cacacaaggc
     1561 atttgttgta acctgtgatg tcactgttta ttgatctctt ctctttcaac tacatttttt
//
LOCUS       NM_001107601            2293 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            6, mRNA.
ACCESSION   NM_001107601 XM_001058773 XM_219948
VERSION     NM_001107601.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058773.1, XM_219948.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2293
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     exon            1..563
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    461..463
                     /gene="Ldb1"
                     /note="upstream in-frame stop codon"
     exon            564..666
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..1774
                     /gene="Ldb1"
                     /note="isoform 6 is encoded by transcript variant 6; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 6"
                     /protein_id="NP_001101071.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQN
                     WTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATE
                     LYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKT
                     WHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQE
                     LMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGG
                     NTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAAN
                     GIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ"
     misc_feature    746..1351
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    746..1351
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    1544..1630
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     misc_feature    1544..1630
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     exon            667..711
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..787
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..890
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1063
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1186
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1270
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1394
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1543
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2293
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggagag ggagggagga gggagagaaa gggagaaagg aaggagcagg cgggcgctgc
       61 gtgtgtctga gtgtgccagt gtgagtgagt gtgagtgccg ggccctgcct ctcccgcctc
      121 ccctgcagag gggcccggtg gcctagggag ggcgggcggg ctgcttggag gcagaggcag
      181 cgagaggcgg cggcgggcag agccgaggag gaggaggaga gaggaaagag ccgagcagcc
      241 attgttgagg gaaaccttgc aaacaaagaa ggctccggac tccccgcggc cccccgcccc
      301 ccaggccggc cccctggccc ccagcccccg gcccagtggc cattgtaact ttccccccgg
      361 gctgtggacc ccgcggggcg ggcggaggct gtgcatgcga gtctttgtgc ggcctgcgga
      421 gtggagctcc cagccagacc ggcctgtccc actcgggaca tgagctgctg aagttggctc
      481 caccttagtc ctcacccttg ccagggtccc tgaggacttc caggcgctcc ccgcacctcc
      541 cctgaccccc tcagttctcc caggttgttc ctcaaagtca ttcaagctgt actccccgaa
      601 ggagcccccg aacggcaacg ccttccctcc cttccatccc ggcaccatgc tggatcggga
      661 tgtgggccca actcccatgt acccacctac atacctggag cctgggatag ggaggcacac
      721 gccatatggt aaccagacag actatagaat atttgaactt aacaaacgac tacagaactg
      781 gacagaggag tgtgacaatc tctggtggga cgctttcacg accgagttct tcgaggatga
      841 tgctatgctg accatcactt tctgcctgga ggatggacca aagagatata ccattggccg
      901 gaccctgata ccacgctact tccgaagcat tttcgagggg ggtgctacgg agctgtatta
      961 cgtacttaag caccccaagg aggcattcca cagcaacttc gtgtccctcg actgtgacca
     1021 gggcagcatg gtgacccagc atggcaaacc catgtttacc caggtgtgtg tggaaggccg
     1081 gttgtacctg gagttcatgt ttgacgacat gatgcggata aagacatggc acttcagtat
     1141 ccggcagcac agagagctca tccccaggag tatcctggcc atgcacgccc aggaccccca
     1201 gatgttggat cagctctcca aaaacattac ccggtgtggg ttgtccaatt ccactctcaa
     1261 ctacctccga ctctgtgtga tactggagcc catgcaggaa ctcatgtccc gtcacaagac
     1321 ctacagcctc agcccccgag actgcctcaa gacctgcctt ttccagaagt ggcagcggat
     1381 ggtagcacct cccgcggagc ctgcacgaca gcagcccagc aaacggagga aacggaagat
     1441 gtcagggggt agcaccatga gctcgggggg cggcaacacc aacaacagca acagcaagaa
     1501 gaagagccca gccagcacct tcgctctctc cagccaggta cctgatgtga tggtggtggg
     1561 ggagcccacc ctgatgggcg gggagttcgg ggacgaggac gagaggctca tcactcggct
     1621 ggagaacacc cagtttgacg cggccaacgg cattgacgac gaggacagct ttaacaactc
     1681 ccctgcactg ggcgccaaca gcccctggaa cagcaagcct ccgtccagcc aagaaagcaa
     1741 atcggagaac cccacgtcac aggcttccca gtaaaggccc taccacggcc acccaggtct
     1801 ctgcctgcta cccctcacag ctccagggag cagaagccag aacgaagaga ctgggcgtct
     1861 gaaatgggca acctccatct acccacttca gggagggact ggactcgctg ggggcaggtg
     1921 ccaagatttg cccccgagtt gccctgggct gggcctggcc cctgcagagc cttttggggg
     1981 aagggggtac tcatgtggat gcctatatgg accctgggct tctgagaaat gtcctgaccc
     2041 tcctctcccc agggcatttg tccccattcg taccccaggt tctgggtacc ccatcttcct
     2101 gatttatccc tttgagcctg gggtttatac ccacagccct taggggctaa atgttggggc
     2161 cttggttgaa tgccctttcc cctaggcggc tgtcaacaga gggtaaaatt ctgggctcct
     2221 cccttttgcc acttacccag ctccaagttt ttaaaaaaaa ataatattat taaaaatgta
     2281 aattaaaaaa aaa
//
LOCUS       NM_012707               1081 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus glucagon (Gcg), mRNA.
ACCESSION   NM_012707
VERSION     NM_012707.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Nakamori,H., Niimi,A., Mitsui,R. and Hashitani,H.
  TITLE     Lipopolysaccharide accelerates peristalsis by stimulating
            glucagon-like peptide-1 release from L cells in the rat proximal
            colon
  JOURNAL   J Physiol 602 (19), 4803-4820 (2024)
   PUBMED   39287487
  REMARK    GeneRIF: Lipopolysaccharide accelerates peristalsis by stimulating
            glucagon-like peptide-1 release from L cells in the rat proximal
            colon.
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Ali,I.I., D'Souza,C., Tariq,S. and Adeghate,E.A.
  TITLE     Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon
            Release in Diabetes Mellitus
  JOURNAL   Int J Mol Sci 25 (18), 9824 (2024)
   PUBMED   39337311
  REMARK    GeneRIF: Adropin Is Expressed in Pancreatic Islet Cells and Reduces
            Glucagon Release in Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Randolph,A.B., Zheng,H. and Rinaman,L.
  TITLE     Populations of Hindbrain Glucagon-Like Peptide 1 (GLP1) Neurons
            That Innervate the Hypothalamic PVH, Thalamic PVT, or Limbic
            Forebrain BST Have Axon Collaterals That Reach All Central Regions
            Innervated by GLP1 Neurons
  JOURNAL   J Neurosci 44 (31), e2063232024 (2024)
   PUBMED   38811166
  REMARK    GeneRIF: Populations of Hindbrain Glucagon-Like Peptide 1 (GLP1)
            Neurons That Innervate the Hypothalamic PVH, Thalamic PVT, or
            Limbic Forebrain BST Have Axon Collaterals That Reach All Central
            Regions Innervated by GLP1 Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Wang,Q.Y., Zhang,W., Zhao,Y., Chen,H.L., Liu,Q., Wang,Z.H.,
            Zeng,L.T., Li,J., Chen,S.J., Wei,L., Iwakuma,T. and Cai,J.P.
  TITLE     Colonic L-cell impairment in aged subjects with type 2 diabetes
            leads to diminished GLP-1 production
  JOURNAL   Diabetes Metab Syndr 17 (12), 102907 (2023)
   PUBMED   37980723
  REMARK    GeneRIF: Colonic L-cell impairment in aged subjects with type 2
            diabetes leads to diminished GLP-1 production.
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Zhu,Y., Tian,J., Shao,Y.W., Zhao,J., Jia,S.H. and Shu,Q.
  TITLE     [Electroacupuncture improves obesity and promotes white adipose
            tissue browning by regulating central glucagon-like peptide-1]
  JOURNAL   Zhen Ci Yan Jiu 48 (8), 727-735 (2023)
   PUBMED   37614130
  REMARK    GeneRIF: [Electroacupuncture improves obesity and promotes white
            adipose tissue browning by regulating central glucagon-like
            peptide-1].
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Mojsov,S., Kopczynski,M.G. and Habener,J.F.
  TITLE     Both amidated and nonamidated forms of glucagon-like peptide I are
            synthesized in the rat intestine and the pancreas
  JOURNAL   J Biol Chem 265 (14), 8001-8008 (1990)
   PUBMED   1692320
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Yamato,E., Noma,Y., Tahara,Y., Ikegami,H., Yamamoto,Y., Cha,T.,
            Yoneda,H., Ogihara,T., Ohboshi,C., Hirota,M. et al.
  TITLE     Suppression of synthesis and release of glucagon by glucagon-like
            peptide-1 (7-36 amide) without affect on mRNA level in isolated rat
            islets
  JOURNAL   Biochem Biophys Res Commun 167 (2), 431-437 (1990)
   PUBMED   2182011
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Mojsov,S., Heinrich,G., Wilson,I.B., Ravazzola,M., Orci,L. and
            Habener,J.F.
  TITLE     Preproglucagon gene expression in pancreas and intestine
            diversifies at the level of post-translational processing
  JOURNAL   J Biol Chem 261 (25), 11880-11889 (1986)
   PUBMED   3528148
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Heinrich,G., Gros,P., Lund,P.K., Bentley,R.C. and Habener,J.F.
  TITLE     Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded
            amino acid sequences of the rat pancreatic complementary
            deoxyribonucleic acid
  JOURNAL   Endocrinology 115 (6), 2176-2181 (1984)
   PUBMED   6548696
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Heinrich,G., Gros,P. and Habener,J.F.
  TITLE     Glucagon gene sequence. Four of six exons encode separate
            functional domains of rat pre-proglucagon
  JOURNAL   J Biol Chem 259 (22), 14082-14087 (1984)
   PUBMED   6094539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced NM_012707.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP480555.1, SRR26643288.13684.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  67531454-67531533   c
            81-185              JAXUCZ010000003.1  67528400-67528504   c
            186-347             JAXUCZ010000003.1  67526487-67526648   c
            348-485             JAXUCZ010000003.1  67524781-67524918   c
            486-629             JAXUCZ010000003.1  67523667-67523810   c
            630-1081            JAXUCZ010000003.1  67522489-67522940   c
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1081
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="glucagon"
                     /db_xref="GeneID:24952"
                     /db_xref="RGD:2668"
     exon            1..80
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..185
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..636
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="glucagon-like peptide-1; pro-glucagon;
                     glucagon-like peptide 2"
                     /codon_start=1
                     /product="pro-glucagon preproprotein"
                     /protein_id="NP_036839.2"
                     /db_xref="GeneID:24952"
                     /db_xref="RGD:2668"
                     /translation="MKTVYIVAGLFVMLVQGSWQHAPQDTEENARSFPASQTEPLEDP
                     NQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGT
                     FTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIAEELGRRHADGSFSDEMNTILD
                     NLATRDFINWLIQTKITDKK"
     sig_peptide     94..153
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
     proprotein      154..633
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="glucagon proprotein"
     mat_peptide     154..360
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="Glicentin.
                     /evidence=ECO:0000250|UniProtKB:P01274.
                     /id=PRO_0000011303"
                     /note="propagated from UniProtKB/Swiss-Prot (P06883.1)"
     mat_peptide     154..243
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="glicentin-related polypeptide (GRPP)"
     misc_feature    160..270
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="propagated from UniProtKB/Swiss-Prot (P06883.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    247..252
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK2. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06883.1); cleavage
                     site"
     mat_peptide     250..360
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="Oxyntomodulin.
                     /evidence=ECO:0000269|PubMed:7937770. /id=PRO_0000011305"
                     /note="propagated from UniProtKB/Swiss-Prot (P06883.1)"
     mat_peptide     250..336
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="glucagon"
     misc_feature    250..333
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    250..333
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    253..255
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55095; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); phosphorylation site"
     misc_feature    340..345
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK1 and PCSK2.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); cleavage site"
     misc_feature    364..369
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK1. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06883.1); cleavage
                     site"
     mat_peptide     367..477
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="Glucagon-like peptide 1.
                     /evidence=ECO:0000250|UniProtKB:P01275.
                     /id=PRO_0000011308"
                     /note="propagated from UniProtKB/Swiss-Prot (P06883.1)"
     misc_feature    382..387
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK1. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06883.1); cleavage
                     site"
     mat_peptide     385..477
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="Glucagon-like peptide 1(7-37).
                     /evidence=ECO:0000250|UniProtKB:P01275.
                     /id=PRO_0000011309"
                     /note="propagated from UniProtKB/Swiss-Prot (P06883.1)"
     mat_peptide     385..474
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="glucagon-like peptide 1 (GLP1)"
     misc_feature    385..468
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    385..468
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    406..408
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55095; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); phosphorylation site"
     misc_feature    415..417
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55095; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); phosphorylation site"
     misc_feature    472..474
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Arginine amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P06883.1); amidation site"
     misc_feature    481..486
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK1. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06883.1); cleavage
                     site"
     misc_feature    526..531
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Cleavage, by PCSK1. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06883.1); cleavage
                     site"
     mat_peptide     529..627
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /product="glucagon-like peptide 2 (GLP2)"
     misc_feature    529..612
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    529..612
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Peptide hormone; Region: Hormone_2; pfam00123"
                     /db_xref="CDD:459681"
     misc_feature    541..543
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55095; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); phosphorylation site"
     misc_feature    547..549
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P06883.1); phosphorylation site"
     exon            186..347
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
     exon            348..485
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..629
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1081
                     /gene="Gcg"
                     /gene_synonym="GLP-1; Glp1; Glp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcttggg cgcagaacac actcaaagtt cccaaaggag ctccacctgt ctacacctcc
       61 tctcagctca gtcccacaag gcagaataaa aaaatgaaga ccgtttacat cgtggctgga
      121 ttgtttgtaa tgctggtaca aggcagctgg cagcatgccc ctcaagacac ggaggagaac
      181 gccagatcat tcccagcttc ccagacagaa ccacttgaag accctaatca gataaacgaa
      241 gacaaacgcc attcacaggg cacattcacc agtgactaca gcaaatacct ggactcccgc
      301 cgtgctcaag attttgtgca gtggttgatg aacaccaaga ggaaccggaa caacattgcc
      361 aaacgtcatg atgaatttga gaggcatgct gaagggacct ttaccagtga tgtgagttct
      421 tacttggagg gccaggcagc aaaggaattc attgcttggc tggtgaaagg ccgaggaagg
      481 cgagacttcc cggaagaagt cgccatagct gaggaacttg ggcgcagaca tgctgatgga
      541 tccttctctg atgagatgaa cacgattctc gataaccttg ccaccagaga cttcatcaac
      601 tggctgattc aaaccaagat cactgacaag aaataggaat atttcaccat tcacaaccat
      661 cttcacaaca tctcctgcca gtcacttggg atgtacattt gagagctata tcctgaagct
      721 atactgcttt gcatgcggac gaatacattt ccctttagcg ttgtgtaacc caaaggttgt
      781 aaatggaata aagtttttcc agggtgttga taaagtaaca actttacagt atgaaaatgc
      841 tggattctca aattgtctcc tcgttttgaa gttaccgccc tgagattact tttctgtggt
      901 ataaattgta aattatcgca gtcacgacac ctggattaca acaacagaag acatggtaac
      961 ctggtaaccg tagtggtgaa cctggaaaga gaacttcttc cttgaaccct ttgtcataaa
     1021 tgcgctcagc tttcaatgta tcaagaatag atttaaataa atatctcatc ctttgttatt
     1081 a
//
LOCUS       NM_001037975            4636 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus murinoglobulin 5 (Mug5), mRNA.
ACCESSION   NM_001037975 XM_216246
VERSION     NM_001037975.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Enghild,J.J., Salvesen,G., Thogersen,I.B. and Pizzo,S.V.
  TITLE     Proteinase binding and inhibition by the monomeric
            alpha-macroglobulin rat alpha 1-inhibitor-3
  JOURNAL   J Biol Chem 264 (19), 11428-11435 (1989)
   PUBMED   2472396
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Northemann,W., Shiels,B.R., Braciak,T.A. and Fey,G.H.
  TITLE     Structure and negative transcriptional regulation by
            glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene
  JOURNAL   Biochemistry 28 (1), 84-95 (1989)
   PUBMED   2495816
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Braciak,T.A., Northemann,W., Hudson,G.O., Shiels,B.R., Gehring,M.R.
            and Fey,G.H.
  TITLE     Sequence and acute phase regulation of rat alpha 1-inhibitor III
            messenger RNA
  JOURNAL   J Biol Chem 263 (8), 3999-4012 (1988)
   PUBMED   2831216
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Schweizer,M., Takabayashi,K., Geiger,T., Laux,T., Biermann,G.,
            Buhler,J.M., Gauthier,F., Roberts,L.M. and Heinrich,P.C.
  TITLE     Identification and sequencing of cDNA clones for the rodent
            negative acute-phase protein alpha 1-inhibitor 3
  JOURNAL   Eur J Biochem 164 (2), 375-381 (1987)
   PUBMED   2436907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 4, 2012 this sequence version replaced NM_001037975.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03552.1, SRR26643286.14756.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000004.1  156652373-156652537
            166-349             JAXUCZ010000004.1  156653711-156653894
            350-509             JAXUCZ010000004.1  156654617-156654776
            510-562             JAXUCZ010000004.1  156654884-156654936
            563-583             JAXUCZ010000004.1  156668834-156668854
            584-752             JAXUCZ010000004.1  156669243-156669411
            753-837             JAXUCZ010000004.1  156669793-156669877
            838-946             JAXUCZ010000004.1  156670842-156670950
            947-1067            JAXUCZ010000004.1  156676327-156676447
            1068-1177           JAXUCZ010000004.1  156676586-156676695
            1178-1339           JAXUCZ010000004.1  156677355-156677516
            1340-1567           JAXUCZ010000004.1  156684605-156684832
            1568-1631           JAXUCZ010000004.1  156685037-156685100
            1632-1780           JAXUCZ010000004.1  156687308-156687456
            1781-1930           JAXUCZ010000004.1  156689298-156689447
            1931-2059           JAXUCZ010000004.1  156690678-156690806
            2060-2144           JAXUCZ010000004.1  156691481-156691565
            2145-2328           JAXUCZ010000004.1  156693866-156694049
            2329-2557           JAXUCZ010000004.1  156694607-156694835
            2558-2684           JAXUCZ010000004.1  156695571-156695697
            2685-2806           JAXUCZ010000004.1  156695955-156696076
            2807-2858           JAXUCZ010000004.1  156696553-156696604
            2859-2942           JAXUCZ010000004.1  156698352-156698435
            2943-3119           JAXUCZ010000004.1  156698700-156698876
            3120-3207           JAXUCZ010000004.1  156699081-156699168
            3208-3364           JAXUCZ010000004.1  156700202-156700358
            3365-3439           JAXUCZ010000004.1  156700581-156700655
            3440-3619           JAXUCZ010000004.1  156701397-156701576
            3620-3843           JAXUCZ010000004.1  156702320-156702543
            3844-4062           JAXUCZ010000004.1  156703890-156704108
            4063-4190           JAXUCZ010000004.1  156704261-156704388
            4191-4281           JAXUCZ010000004.1  156705412-156705502
            4282-4350           JAXUCZ010000004.1  156706137-156706205
            4351-4453           JAXUCZ010000004.1  156707037-156707139
            4454-4495           JAXUCZ010000004.1  156708280-156708321
            4496-4635           JAXUCZ010000004.1  156708632-156708771
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4636
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="murinoglobulin 5"
                     /db_xref="GeneID:297568"
                     /db_xref="RGD:1584999"
     exon            1..165
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    29..31
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="upstream in-frame stop codon"
     CDS             80..4513
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="murinoglobulin-2-like; alpha-1-inhibitor 3;
                     alpha-1-inhibitor III; murinoglobulin 1 like 1"
                     /codon_start=1
                     /product="alpha-1-inhibitor 3 precursor"
                     /protein_id="NP_001033064.2"
                     /db_xref="GeneID:297568"
                     /db_xref="RGD:1584999"
                     /translation="MKKDREAQLCLFSALLAFLPFASLLNGNSKYMVLVPSQLYTETP
                     EKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKDLFHCVSFTIPRLPSSEEEES
                     LDINIEGAKHKFSERRVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSMDKNLHPLNE
                     LFPLAYIEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHS
                     FTVMEFVLPRFGVDVKVPNAISVYDEIINVTACATYTYGKPVPGHVKISLCHGNPTFS
                     SETKSACKEEDSRLDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFS
                     GSGRIEVERTRNKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVLIKARDAGYT
                     NATTTDQHGLAKFSIDTSGISDYSLNIKVYHKEESSCIHSSCTAERHAEAHHTAYAVY
                     SLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLQQIVFHYLVMAQGSILQTGN
                     HTHQVEPGESQVQGNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVKFQVEKCLRN
                     KVQLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLQKPEAELSPSLIYDLPGM
                     QDSNFIASSNDPFEDEDYCLMYQPIAREKDVYRYVRETGLMAFTNLKIKLPTYCNTDY
                     DMVPLAVPAVALDSSTDRGMYESLPVVAVKSPLPQEPPRKDPPPKDPVIETIRNYFPE
                     TWIWDLVTVNSSGVTELEMTVPDTITEWKAGALCLSNDTGLGLSSVASFQAFQPFFVE
                     LTMPYSVIRGEAFTLKATVLNYLPTSLPMAVLLEASPDFTAVPVENNQDSYCLGANGR
                     HTSSWLVTPKSLGNVNFSVSAEARQSPGPCGSEVATVPETGRKDTVVKVLIVEPEGIK
                     KEHTFSSLLCASDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMP
                     YGCGEQNMVLFAPNIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSA
                     FGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGS
                     LLNNAMKGGVDDEITLSAYITMALLESSLPDTDPVVSKALSCLESSWENIEQGGNGSF
                     VYTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWERPQKPTKSEGYLYTPQA
                     SSAEVEMSAYVVLARLTAQPAPSPEDLALSMGTIKWLTKQQNSYGGFSSTQDTVVALD
                     ALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVSLPYIPGNYTVSVS
                     GEGCVYAQTTLRYNVPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYTGSRPA
                     SNMVIADVKMLSGFIPLKPTVKKLERLGHVSRTEVTTNNVLLYLDQVTNQTLSFSFII
                     QQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDDQNV"
     sig_peptide     80..151
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (P14046.1)"
     mat_peptide     152..4510
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /product="Alpha-1-inhibitor 3. /id=PRO_0000000061"
                     /note="propagated from UniProtKB/Swiss-Prot (P14046.1)"
     misc_feature    242..244
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    <464..4126
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; Region: YfaS; COG2373"
                     /db_xref="CDD:441940"
     misc_feature    <464..4126
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; Region: YfaS; COG2373"
                     /db_xref="CDD:441940"
     misc_feature    818..820
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    980..982
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    1040..1042
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    1256..1258
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    1601..1603
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    1880..2329
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="propagated from UniProtKB/Swiss-Prot (P14046.1);
                     Region: Bait region (approximate)"
     misc_feature    2327..2329
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    2408..2410
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    2693..2695
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    2960..3880
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="Proteins similar to alpha2-macroglobulin (alpha
                     (2)-M). This group also contains the pregnancy zone
                     protein (PZP). Alpha(2)-M and PZP are broadly specific
                     proteinase inhibitors. Alpha (2)-M is a major carrier
                     protein in serum. The structural thioester...; Region:
                     A2M_2; cd02897"
                     /db_xref="CDD:239227"
     misc_feature    2960..3880
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="Proteins similar to alpha2-macroglobulin (alpha
                     (2)-M). This group also contains the pregnancy zone
                     protein (PZP). Alpha(2)-M and PZP are broadly specific
                     proteinase inhibitors. Alpha (2)-M is a major carrier
                     protein in serum. The structural thioester...; Region:
                     A2M_2; cd02897"
                     /db_xref="CDD:239227"
     misc_feature    order(3002..3004,3008..3013,3020..3022,3140..3142,
                     3170..3172,3179..3181,3341..3343,3347..3352,3830..3832)
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="surface patch; other site"
                     /db_xref="CDD:239227"
     misc_feature    order(3002..3004,3008..3013,3020..3022,3140..3142,
                     3170..3172,3179..3181,3341..3343,3347..3352,3830..3832)
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="surface patch; other site"
                     /db_xref="CDD:239227"
     misc_feature    3002..3013
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="thioester region [active]"
                     /db_xref="CDD:239227"
     misc_feature    3002..3013
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="thioester region [active]"
                     /db_xref="CDD:239227"
     misc_feature    3059..3061
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    order(3308..3310,3320..3322,3326..3328,3350..3352)
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="specificity defining residues; other site"
                     /db_xref="CDD:239227"
     misc_feature    order(3308..3310,3320..3322,3326..3328,3350..3352)
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="specificity defining residues; other site"
                     /db_xref="CDD:239227"
     misc_feature    3506..3508
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    4019..4021
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     misc_feature    4208..4480
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="A-macroglobulin receptor binding domain; Region:
                     A2M_recep; pfam07677"
                     /db_xref="CDD:462226"
     misc_feature    4208..4480
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="A-macroglobulin receptor binding domain; Region:
                     A2M_recep; pfam07677"
                     /db_xref="CDD:462226"
     misc_feature    4358..4360
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14046.1); glycosylation site"
     exon            166..349
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..509
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..562
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..583
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..752
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..837
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..946
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1067
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1177
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1339
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1567
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1631
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1780
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1930
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2059
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2144
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2328
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2557
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2684
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2806
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2858
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2942
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3119
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3207
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3364
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3439
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3620
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3844
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4063
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4191
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4192..4282
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4351
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4454
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4496
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..4636
                     /gene="Mug5"
                     /gene_synonym="A1i3; alpha-1-I3; Mug1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcagtg ttaaggaaga ggacagcata agccctgtcc tcttgtcttc ctgtcgtcct
       61 gtcctcctgt ccttccatca tgaagaagga cagagaggct cagctgtgcc ttttttcagc
      121 tcttcttgcc ttcctgcctt ttgcttcctt gctcaatgga aactcgaagt atatggtgct
      181 ggtcccgtcc cagctctaca ccgagacccc tgagaaaatc tgcctgcatc tataccatct
      241 gaatgagaca gtgactgtga cagcttcctt gatatctcaa aggggaacga gaaaactgtt
      301 cgatgagctt gtggttgaca aggacttgtt ccactgtgtt tccttcacta tccctagatt
      361 gccctcttct gaagaggagg agtcactcga catcaacatt gaaggggcta agcataaatt
      421 cagcgaaagg cgtgtggtgc ttgtgaagaa caaagaaagt gttgtctttg tccagactga
      481 taagcccatg tacaagccag gacagtcagt taaatttcgg gttgtctcta tggataaaaa
      541 tctacacccc ctgaatgagt tgtttcctct ggcttacatt gaggatccga aaatgaaccg
      601 aattatgcag tggcaagacg ttaagactga gaatgggctt aagcaactgt ccttcagcct
      661 gtcagcagag cccattcagg gcccctacaa gatagtgatt ctcaaacagt caggagtgaa
      721 ggaagagcat tccttcactg taatggaatt cgtgcttccc agatttggtg tcgacgtgaa
      781 ggtcccaaac gccatctctg tgtacgatga aataatcaat gtgactgcct gtgcaacata
      841 tacctatggg aagcctgtcc caggacatgt aaagataagt ctttgccatg gaaatccaac
      901 ctttagctct gagacaaagt ctgcatgcaa agaagaggac tccaggctag acaacaacgg
      961 ctgcagcaca caagaagtga acatcactga gttccaatta aaggaaaatt acctcaaaat
     1021 gcaccaggct ttccatgtga atgcaactgt tacagaagaa gggacagggt cagagttcag
     1081 tggatctgga agaattgaag tcgaaagaac cagaaacaaa ttcctatttt tgaaagcaga
     1141 ttcacacttc agacacggga tcccattctt tgtgaaagtc cgcctagtgg atatcaaggg
     1201 agatcctatt ccaaatgagc aggtcctcat caaagcacga gacgctggct acaccaatgc
     1261 tactaccact gatcagcatg gcttggcaaa gttctccata gataccagcg gcatctcaga
     1321 ctattccctc aatatcaaag tctaccacaa ggaggaaagt tcatgtatcc attcctcttg
     1381 cacagcagaa agacacgcag aggcacatca tacggcctat gctgtttact ccctcagcaa
     1441 gagctacatc tacctcgaca cagaagctgg cgtcttgccc tgcaaccaga tccacacagt
     1501 tcaggcgcat tttattctga aggggcaggt cttgggagtg ctgcaacaga ttgttttcca
     1561 ctacctggtc atggcccagg gcagcatcct ccagactgga aaccacactc atcaagtgga
     1621 gccaggagaa tctcaagtac aaggcaactt cgccttggag atccctgtgg agttcagcat
     1681 ggttcccgtg gctaaaatgc tcatctacac catcttgcct gatggagaag tgattgcaga
     1741 ttctgtaaag tttcaagttg aaaaatgtct tcgcaacaaa gtgcagctga gcttcagccc
     1801 atcccaaagt cttccagcct cacaaaccca tatgcgggtt acagcttctc ctcagtccct
     1861 ctgtggcctg agagctgtgg accaaagcgt gctgctccag aagcctgagg ctgagctctc
     1921 cccttccttg atatatgatc taccaggtat gcaagacagc aacttcattg caagttccaa
     1981 tgatccattt gaagacgaag actattgttt gatgtaccaa ccaatcgccc gagaaaagga
     2041 tgtctacaga tacgtgaggg aaacgggttt aatggcattc accaacttga agatcaaact
     2101 tcctacatat tgtaatactg actatgacat ggttccatta gcagtacctg ctgtggcctt
     2161 ggattcttca actgacaggg gaatgtatga gagcttgccc gtggtagcag tgaaaagccc
     2221 actgcctcaa gagccaccac gtaaagatcc accacctaaa gatccagtta ttgagaccat
     2281 taggaattat tttcctgaaa cctggatctg ggatttagtc acagtaaact cctcaggagt
     2341 gactgaactg gaaatgacag tccctgacac tatcactgaa tggaaggctg gagctctctg
     2401 cctgtccaat gacactggtc ttggcctctc ttctgtggca tctttccaag ccttccagcc
     2461 cttctttgtg gagctcacaa tgccctactc tgtgatccgt ggagaagcct tcacactcaa
     2521 ggccactgtc ctgaactacc tccctacaag cttgccgatg gcagtgctgc tggaagcttc
     2581 tcctgatttc acagctgtcc cagtggagaa caatcaagat tcttactgcc ttggtgccaa
     2641 tgggaggcac acctcatcct ggttggtaac tcccaaatct ctagggaatg tgaatttctc
     2701 tgtgtctgcg gaagcacgac agtcaccagg gccctgtggt tctgaggtgg ccaccgttcc
     2761 tgaaaccggg agaaaggaca cagtagtcaa ggtcttgata gttgagcctg aaggaatcaa
     2821 gaaagagcat accttcagct cactgctctg tgcatcagat gctgagctat cggaaacatt
     2881 gtctctgctg cttccaccaa cagtagtgaa agattcagcc agagcacatt tctctgtgat
     2941 gggtgatatc ttgagttcag ccataaaaaa cacacaaaat cttatccaaa tgccttatgg
     3001 ctgtggggag cagaacatgg tcctttttgc tccgaacatc tatgttctga aatatctgaa
     3061 tgaaactcaa cagctgacag agaagatcaa gtccaaggcc cttggttacc tcagagctgg
     3121 ttatcagaga gaactgaact acaaacacaa agatggctcc tacagtgctt ttggggatca
     3181 caatggccag ggtcaaggaa acacttggct cacagccttt gtgctcaagt cttttgccca
     3241 agctcgagcc ttcatcttca tcgacgaatc acacatcacc gacgccttca cctggctctc
     3301 caagcagcag aaggacagtg gctgcttcag gagctccgga tcactgctca acaatgccat
     3361 gaagggggga gtcgatgatg aaatcaccct ctctgcctat ataaccatgg cccttctgga
     3421 aagttcactc ccagacacag atcccgttgt ctccaaagcc ctgagctgcc tagagtcatc
     3481 ttgggagaac atagagcaag gaggaaatgg cagcttcgtg tacaccaagg cactgatggc
     3541 ctatgctttc gctctggcag ggaaccagga gaagagaaat gaaatcctga aatcccttga
     3601 taaggaagct ataaaggaag acaactccat ccactgggaa agacctcaga aacccacaaa
     3661 atcagagggt tatctgtaca caccccaggc ttcctctgct gaagtagaga tgagtgccta
     3721 tgtcgtctta gctcgcctca ctgcccagcc agccccatcc cctgaagacc tggctttgtc
     3781 aatgggcacc atcaagtggc tcacaaagca gcagaattcc tatggtggct tctcctcgac
     3841 acaggacact gtggtggccc tcgatgctct gtccaaatac ggagcagcta ctttttccaa
     3901 aagccagaaa actccttcgg tgaccgtcca atcttcaggg tcattttccc aaaagttcca
     3961 agtagacaag agtaatcgtc tgttactgca gcaggtctca ttaccataca ttcctgggaa
     4021 ctataccgtc agtgtgtcag gggaaggatg tgtgtatgct cagaccacgc tgagatataa
     4081 tgtgcccttg gagaagcagc agcctgcatt tgctctaaag gtgcagacag tacccctgac
     4141 ttgtaacaac cccaaaggcc agaacagctt ccagatctca ctagaaatca gttacacggg
     4201 gagccgtcca gcctccaaca tggtgattgc tgatgtgaag atgctctctg gtttcatccc
     4261 attgaaacca acagtgaaga agcttgaaag attagggcat gtgagcagaa cagaagtgac
     4321 caccaacaac gtcctgttat atttggacca ggtaaccaat cagacactgt ccttctcctt
     4381 catcattcaa caagacatcc cagtaaagaa cctgcagcct gccattgtga aagtgtatga
     4441 ctactatgag acagatgaag tggcttttgc tgaatacagc agcccctgca gctcagacga
     4501 ccaaaatgtt tgaaactcat atctgtggac aaggcattgc tggaatcccc agaccaggga
     4561 accttcaaga aggtgatttg tgtttgtctc tgaaatacaa atactgaaca agcttgataa
     4621 ataaatacat aattct
//
LOCUS       NM_001185025            1157 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus NUBP iron-sulfur cluster assembly factor,
            mitochondrial (Nubpl), mRNA.
ACCESSION   NM_001185025 XM_001075426 XM_216689
VERSION     NM_001185025.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Sheftel,A.D., Stehling,O., Pierik,A.J., Netz,D.J., Kerscher,S.,
            Elsasser,H.P., Wittig,I., Balk,J., Brandt,U. and Lill,R.
  TITLE     Human ind1, an iron-sulfur cluster assembly factor for respiratory
            complex I
  JOURNAL   Mol Cell Biol 29 (22), 6059-6073 (2009)
   PUBMED   19752196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP486352.1, CO399813.1 and BF282469.1.
            
            On or before Jun 1, 2010 this sequence version replaced
            XM_216689.6, XM_001075426.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132296 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BP486352.1         7-30
            25-628              CO399813.1         1-604
            629-1157            BF282469.1         1-529               c
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1157
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="NUBP iron-sulfur cluster assembly factor,
                     mitochondrial"
                     /db_xref="GeneID:299008"
                     /db_xref="RGD:1307232"
     exon            1..118
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    5..7
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="upstream in-frame stop codon"
     CDS             11..970
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="iron-sulfur protein NUBPL; nucleotide binding
                     protein-like; iron-sulfur cluster transfer protein NUBPL;
                     NUBP iron-sulfur cluster assembly factor like"
                     /codon_start=1
                     /product="iron-sulfur cluster transfer protein NUBPL
                     precursor"
                     /protein_id="NP_001171954.1"
                     /db_xref="GeneID:299008"
                     /db_xref="RGD:1307232"
                     /translation="MGTWRRLLLFGGVSLRGGGVAAALPLGCRALGCGRQLLGAEGEA
                     LKQRRTQIMSRGLPKQKPIEGVREVIVVASGKGGVGKSTTAVNLALALAANDSSKAVG
                     LLDVDVYGPSIPKMMNLKGNPELSPNNLMRPLLNYGIACMSMGFLVEETAPLVWRGLM
                     VMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDA
                     HKGAEMFRKVNVPVLGLVQNMSVFQCPQCKHKTHIFGADGARKLAQTLDLDVLGDVPL
                     HLSIREASDMGQPVVFSQPESDEAKAYLNIASEVVRRLKSPPE"
     misc_feature    203..943
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="NUBPL iron-transfer P-loop NTPase; Region: ParA;
                     pfam10609"
                     /db_xref="CDD:431392"
     misc_feature    203..943
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="NUBPL iron-transfer P-loop NTPase; Region: ParA;
                     pfam10609"
                     /db_xref="CDD:431392"
     misc_feature    order(236..259,641..643,647..649,722..727,833..841,
                     848..853)
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="active site"
                     /db_xref="CDD:349757"
     misc_feature    order(236..259,641..643,647..649,722..727,833..841,
                     848..853)
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="active site"
                     /db_xref="CDD:349757"
     misc_feature    order(236..244,335..340,344..346,353..358,479..484,
                     572..574,578..580,587..589,659..661,668..670,836..838,
                     842..847,851..853)
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349757"
     misc_feature    order(236..244,335..340,344..346,353..358,479..484,
                     572..574,578..580,587..589,659..661,668..670,836..838,
                     842..847,851..853)
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349757"
     exon            119..266
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            267..301
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            302..392
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            393..432
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            433..523
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            524..617
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            618..703
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            704..824
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            825..907
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1157
                     /gene="Nubpl"
                     /gene_synonym="RGD1307232"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttgagcc atggggacct ggcggcgttt gctgctcttt ggcggggtgt cactccgggg
       61 tggtggcgtg gccgctgccc tgcccctggg gtgccgagct ttgggttgtg ggcgtcagtt
      121 attaggtgct gagggtgagg ccttgaaaca aagaagaacc caaatcatgt cccgaggact
      181 tcctaagcag aagcctatag agggtgttag agaagttatt gttgtggcct ctggaaaggg
      241 tggtgttgga aagtctacca cggcagtgaa ccttgctctc gccctggctg cgaatgattc
      301 gtctaaggcg gtcggcttgt tggatgtgga tgtgtatggg ccttccattc caaagatgat
      361 gaacctgaaa ggaaatccgg agttatcacc aaataaccta atgaggcctc ttttgaatta
      421 tggtattgct tgtatgtcga tgggcttttt ggttgaagag actgcaccac ttgtttggag
      481 aggccttatg gtaatgtcag ccattgagaa gctactgaga caggttgatt ggggtcaact
      541 ggactattta gttgttgaca tgccaccagg aacaggagac gtgcagttat cagtttcaca
      601 gaatatcccc atttcaggtg ctgtgattgt ctccacgcct caggacattg cactgatgga
      661 tgcacacaag ggtgcggaga tgtttcggaa agtcaatgtg cctgttcttg gccttgtcca
      721 aaacatgagt gtcttccagt gtccacagtg taaacacaaa actcatattt ttggtgctga
      781 tggtgcaaga aaactagcac agacccttga tcttgatgtt ttaggagatg tccccttaca
      841 cctcagtata agggaagctt cagatatggg tcagccagtt gtcttttctc agcctgaaag
      901 tgatgaggcc aaagcttacc tgaatattgc ttcagaagtg gtaagaagat tgaagtcacc
      961 tccagaatga ttcccaagtg ccctggaacg tgtcctggta tttgataatc atgaactgtc
     1021 aaaaatgagc attgtggtag ggtgagaccc accaaaataa tggcaattct gattattttc
     1081 attcatctct aaagaaataa tgtctcgttt tcagatttga tttgatgatc tatgacataa
     1141 ataaaatgtt cgtgtgt
//
LOCUS       NM_001271376            4586 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus murinoglobulin 6 (Mug6), mRNA.
ACCESSION   NM_001271376 XM_001060284 XM_003749832 XM_213006
VERSION     NM_001271376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4586)
  AUTHORS   Schweizer,M., Takabayashi,K., Geiger,T., Laux,T., Biermann,G.,
            Buhler,J.M., Gauthier,F., Roberts,L.M. and Heinrich,P.C.
  TITLE     Identification and sequencing of cDNA clones for the rodent
            negative acute-phase protein alpha 1-inhibitor 3
  JOURNAL   Eur J Biochem 164 (2), 375-381 (1987)
   PUBMED   2436907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Sep 21, 2012 this sequence version replaced
            XM_001060284.2, XM_213006.6, XM_003749832.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000004.1  157084966-157085051 c
            87-270              JAXUCZ010000004.1  157083630-157083813 c
            271-430             JAXUCZ010000004.1  157082731-157082890 c
            431-483             JAXUCZ010000004.1  157082571-157082623 c
            484-504             JAXUCZ010000004.1  157076185-157076205 c
            505-673             JAXUCZ010000004.1  157075750-157075918 c
            674-758             JAXUCZ010000004.1  157075281-157075365 c
            759-867             JAXUCZ010000004.1  157074202-157074310 c
            868-988             JAXUCZ010000004.1  157064473-157064593 c
            989-1098            JAXUCZ010000004.1  157064223-157064332 c
            1099-1260           JAXUCZ010000004.1  157063367-157063528 c
            1261-1488           JAXUCZ010000004.1  157054939-157055166 c
            1489-1552           JAXUCZ010000004.1  157054670-157054733 c
            1553-1701           JAXUCZ010000004.1  157052319-157052467 c
            1702-1851           JAXUCZ010000004.1  157049809-157049958 c
            1852-2013           JAXUCZ010000004.1  157041737-157041898 c
            2014-2089           JAXUCZ010000004.1  157041027-157041102 c
            2090-2273           JAXUCZ010000004.1  157039528-157039711 c
            2274-2502           JAXUCZ010000004.1  157038709-157038937 c
            2503-2629           JAXUCZ010000004.1  157037865-157037991 c
            2630-2751           JAXUCZ010000004.1  157037482-157037603 c
            2752-2803           JAXUCZ010000004.1  157017261-157017312 c
            2804-2887           JAXUCZ010000004.1  157015458-157015541 c
            2888-3064           JAXUCZ010000004.1  157015017-157015193 c
            3065-3152           JAXUCZ010000004.1  157014715-157014802 c
            3153-3309           JAXUCZ010000004.1  157013524-157013680 c
            3310-3384           JAXUCZ010000004.1  157013229-157013303 c
            3385-3565           JAXUCZ010000004.1  157011946-157012126 c
            3566-3789           JAXUCZ010000004.1  157011024-157011247 c
            3790-4008           JAXUCZ010000004.1  157009454-157009672 c
            4009-4136           JAXUCZ010000004.1  157009174-157009301 c
            4137-4227           JAXUCZ010000004.1  157008204-157008294 c
            4228-4296           JAXUCZ010000004.1  157007500-157007568 c
            4297-4399           JAXUCZ010000004.1  157006534-157006636 c
            4400-4441           JAXUCZ010000004.1  157005359-157005400 c
            4442-4586           JAXUCZ010000004.1  157004905-157005049 c
FEATURES             Location/Qualifiers
     source          1..4586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4586
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="murinoglobulin 6"
                     /db_xref="GeneID:297572"
                     /db_xref="RGD:1566313"
     CDS             1..4458
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="alpha-1-inhibitor 3-like; C3 and PZP-like,
                     alpha-2-macroglobulin domain containing 8"
                     /codon_start=1
                     /product="C3 and PZP-like, alpha-2-macroglobulin domain
                     containing 8 precursor"
                     /protein_id="NP_001258305.1"
                     /db_xref="GeneID:297572"
                     /db_xref="RGD:1566313"
                     /translation="MWKNREAHLCLFSVLLALLPSASSFNGNSKYMVLVPSQLYTDTP
                     EKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKDLFHCLSFTIPRLPSSEEEES
                     LDINIEGAKHKFSKRRVVLVKNKESVVFVQTDKPVYKPGQSVKFRIVSMDKNLHPLNE
                     LFPLAYIEDPKINRIMQWQDIKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHS
                     FTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVPGRVKISLCHGNPSFR
                     SQTKSACKEEDSELDNNGCSTQEVNITEFRLKENYLKVRQAFHVNATVTEEGTGSEFS
                     GSGRIEVKRTRNKFLFLKADSHFRHGIPFFVKVRLVNIKGDPIPNQQVFIKAQGAGFT
                     NATTTDQHGLAKFSIDTSGISRYILNIKVYHKEENSCIHSSCTAERHAEAHHTAYAVY
                     SLSKSYIYLDTEAGVLPCNQSHTVQAHFILKGQVLGVLPQIVFHYLVMAQGSILQTGN
                     HTHQVEPGESPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCLRH
                     EVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELSPSLIYDLPGM
                     QESKFIPRSHYPFEDEDGCVIYRPRVIGKLTYSVPYGREKDVFRYMRDTGLTALTNLK
                     LRTFCFDYDMVPLAVPAARSSDLFNSDGYGSWRSARVKSLPPKKAPHKDPPPKDPVIE
                     TIRNYFPETWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQ
                     AFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPDFTAVPVGNDQDS
                     YCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQQSPEPCGSEVATVPETGRKDTVVKVL
                     IVEPEGIKREHTFSSLLCASDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKN
                     TQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYK
                     HKDGSYSAFGDHDGKGQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDS
                     GCFRSSGSLFNNAMKGGVDDEITLSAYITVALLESLPPDTHPVVSKALSCLESSWENI
                     EQGGNGSFVYTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWERPQKPMKSA
                     RSLYKPQASSAEVEMNAYVILARLTAQSAPSPKDLALSMGTIKWLTKQQNSRGGFSST
                     QDTVVALDALSKYGAATFSKSQKTPSVTVQSSGSFFQKFQVDNSNRLLLQQVSLPDIP
                     GNYTVSVSGEGCVYAQTMLRYNLPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEI
                     SYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNNVLLYLDQVTNQ
                     TLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDNQNV"
     sig_peptide     1..72
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    <385..4053
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; Region: YfaS; COG2373"
                     /db_xref="CDD:441940"
     misc_feature    <385..4053
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; Region: YfaS; COG2373"
                     /db_xref="CDD:441940"
     misc_feature    2245..2517
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Alpha-2-macroglobulin family; Region: A2M;
                     pfam00207"
                     /db_xref="CDD:459711"
     misc_feature    2245..2517
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Alpha-2-macroglobulin family; Region: A2M;
                     pfam00207"
                     /db_xref="CDD:459711"
     misc_feature    2905..3825
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Proteins similar to alpha2-macroglobulin (alpha
                     (2)-M). This group also contains the pregnancy zone
                     protein (PZP). Alpha(2)-M and PZP are broadly specific
                     proteinase inhibitors. Alpha (2)-M is a major carrier
                     protein in serum. The structural thioester...; Region:
                     A2M_2; cd02897"
                     /db_xref="CDD:239227"
     misc_feature    2905..3825
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="Proteins similar to alpha2-macroglobulin (alpha
                     (2)-M). This group also contains the pregnancy zone
                     protein (PZP). Alpha(2)-M and PZP are broadly specific
                     proteinase inhibitors. Alpha (2)-M is a major carrier
                     protein in serum. The structural thioester...; Region:
                     A2M_2; cd02897"
                     /db_xref="CDD:239227"
     misc_feature    order(2947..2949,2953..2958,2965..2967,3085..3087,
                     3115..3117,3124..3126,3286..3288,3292..3297,3775..3777)
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="surface patch; other site"
                     /db_xref="CDD:239227"
     misc_feature    order(2947..2949,2953..2958,2965..2967,3085..3087,
                     3115..3117,3124..3126,3286..3288,3292..3297,3775..3777)
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="surface patch; other site"
                     /db_xref="CDD:239227"
     misc_feature    2947..2958
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="thioester region [active]"
                     /db_xref="CDD:239227"
     misc_feature    2947..2958
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="thioester region [active]"
                     /db_xref="CDD:239227"
     misc_feature    order(3253..3255,3265..3267,3271..3273,3295..3297)
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="specificity defining residues; other site"
                     /db_xref="CDD:239227"
     misc_feature    order(3253..3255,3265..3267,3271..3273,3295..3297)
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="specificity defining residues; other site"
                     /db_xref="CDD:239227"
     misc_feature    4153..4425
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="A-macroglobulin receptor binding domain; Region:
                     A2M_recep; pfam07677"
                     /db_xref="CDD:462226"
     misc_feature    4153..4425
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /note="A-macroglobulin receptor binding domain; Region:
                     A2M_recep; pfam07677"
                     /db_xref="CDD:462226"
     exon            1..86
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            87..270
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            271..430
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            431..483
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            484..504
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            505..673
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            674..758
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            759..867
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            868..988
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1098
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1260
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1488
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1552
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1701
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1851
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2013
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2089
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2273
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2502
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2629
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2751
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2803
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2887
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3064
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3152
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3309
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3384
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3565
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3789
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..4008
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4136
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4227
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4296
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4399
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4441
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4586
                     /gene="Mug6"
                     /gene_synonym="Cpamd8; RGD1566313"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggaaga acagagaggc tcacctgtgc cttttttcag ttcttcttgc cctcctgcct
       61 tctgcttcct cgttcaatgg aaactcgaag tatatggtgc tggtcccgtc ccagctctac
      121 accgacaccc ctgagaaaat ctgcctgcat ctataccatc tgaatgagac agtgactgtg
      181 acagcttcct tgatatctca aaggggaacg agaaaactgt tcgatgagct tgtggttgac
      241 aaggacttgt tccactgtct ttccttcact atccctagat tgccctcttc tgaagaggag
      301 gagtcactcg acatcaacat agaaggggca aagcataaat tcagcaaaag gcgtgtggtg
      361 cttgtgaaga acaaagaaag tgttgtcttt gtccagactg ataagcccgt gtacaagcca
      421 ggacagtcag ttaaatttcg gattgtctct atggataaaa atctacaccc cctgaatgag
      481 ttgtttcctc tggcttacat tgaggatccc aaaatcaacc gaattatgca gtggcaggac
      541 attaagacag agaatgggct taagcaattg tccttcagcc tgtcagcaga gcccattcag
      601 ggcccctaca agatagtcat tctcaaacag tcaggagtga aggaagagca ttccttcacc
      661 gtcatggaat tcgtgcttcc cagatttggt gtcgatgtga aggtcccaaa cgccatctct
      721 gtgtatgatg agataatcag tgtgactgcc tgtgcgacat atacctatgg gaaacctgtc
      781 ccgggacgtg taaagataag tctttgccat ggaaatcctt cctttagatc tcagacaaag
      841 tctgcatgca aagaagagga ctcggagcta gacaacaacg gctgcagcac acaagaagtg
      901 aacatcactg agttccgatt gaaggaaaat tacctcaaag tgcgccaggc tttccatgtg
      961 aatgcaactg ttacagaaga agggacaggg tcagagttca gtggatctgg aagaattgaa
     1021 gtcaaaagaa ccagaaacaa attcctattt ctgaaagcag attcccactt cagacatggg
     1081 atcccattct ttgtgaaggt ccgcctagtg aatatcaagg gagatcctat cccaaatcag
     1141 caggtcttca tcaaagcaca aggagctggc ttcaccaatg ctactaccac tgatcagcat
     1201 ggcttggcca agttctccat agataccagc ggcatctcac gatatatcct gaatatcaaa
     1261 gtctaccaca aggaggaaaa ttcatgcatc cattcctctt gcacagcaga gagacacgca
     1321 gaggcacatc atacggccta tgctgtttac tccctcagca agagctacat ctaccttgac
     1381 acagaagctg gcgtcttgcc ctgcaaccag agccacacag ttcaggcaca ttttattctg
     1441 aaggggcagg tcttgggagt gctgccacag attgttttcc actacctggt catggcccag
     1501 ggcagcatcc tccagactgg aaaccacact catcaagtgg agccaggaga atctccagta
     1561 caaggcaact tcgccttgga gatccctgtg gagttcagca tggttcccat ggctaaaatg
     1621 ctcatctaca ccatcttgcc tgatggagaa gtgattgcag attctgtaaa gtttcaagtt
     1681 gaaaaatgtc ttcgtcatga agtgcacctg agtttcagcc catcccaaag tcttccagcc
     1741 tcacaaaccc atatgcgggt tacagcttct cctcagtccc tctgtggcct gagagctgtg
     1801 gaccaaagcg tgctgctgct gaagcctgag gctgagctct ccccttcctt gatatatgat
     1861 ctaccaggta tgcaagagag caagttcatt ccacgttccc actatccatt tgaagacgaa
     1921 gatggttgtg tgatataccg accaagagtc attggaaagc tcacatactc agtaccatat
     1981 ggacgagaga aggatgtctt cagatacatg agggacacgg gtttaacggc actcaccaac
     2041 ttgaaacttc gtacattttg ttttgactat gacatggttc cattagcagt acctgctgcc
     2101 cgatctagtg atttatttaa cagcgacggt tatggaagtt ggcgctcagc aagagtaaaa
     2161 agtctacctc ctaaaaaggc accacataaa gatccaccac ctaaagatcc agttattgag
     2221 accattagga attattttcc tgaaacctgg gtctgggatt tagtcacagt aaactcctca
     2281 ggagcagctg aattggaaat gacagtccct gacaccatca ctgaatggaa ggccggagcc
     2341 ctctgcctgt ccaatgacac tggtcttggc ctctcttctg tggcaactct ccaagccttc
     2401 caacctttct ttgtggagct cacaatgccc tactctgtga tccgtggaga agccttcacg
     2461 ctcaaggcca ctgtgatgaa ctacctccct acaagcttgc cgatggcagt gcagctggaa
     2521 gcttctcctg atttcacagc tgtcccagtg ggaaacgacc aagattctta ctgccttggt
     2581 gccaatggaa ggcacacctc atcctggttg gtaactccca aatctttagg gaatgtgaat
     2641 ttctctgtgt ctgcggaagc acaacagtcc ccagagcctt gtggttctga ggtggccaca
     2701 gtgcctgaaa ccgggagaaa ggacacagtc gtcaaagtct tgatagttga gcctgaagga
     2761 atcaagagag agcatacttt cagctcactg ctctgtgcat cagatgctga gctatcagaa
     2821 acattgtctc tgctgcttcc accaacagta gtgaaagatt cagccagagc acatttctct
     2881 gtgatgggtg atatcttgag ttcagccata aaaaacacac aaaatcttat ccaaatgccc
     2941 tatggctgtg gggagcagaa catggtcctt tttgctccga gcatctatgt actgaaatat
     3001 ctgaatgaaa cccaacagct gacagagaag atcaagtcca aggcccttgg ctacctcaga
     3061 gctggttatc agagggaact gaactacaaa cacaaggatg gctcctacag tgcctttggg
     3121 gatcacgatg gcaagggtca aggaaacact tggctcacag cctttgtgct caagtctttt
     3181 tcccaagctc aagccttcat cttcattgac gaatcacaca tcaccgatgc cttcacctgg
     3241 ctctcccatc agcagaagga cagtggctgc ttcaggagct ctggatcact gttcaacaac
     3301 gccatgaagg ggggagttga tgatgaaatc accctctctg cctatataac tgtggccctt
     3361 ttggaaagtt tacccccaga cactcatcct gttgtctcca aagccctgag ctgcctagag
     3421 tcatcttggg agaacataga gcaaggagga aatggcagct tcgtgtacac caaggcactg
     3481 atggcctatg cttttgctct ggcggggaat caggagaaga gaaacgaaat cctgaaatcc
     3541 cttgataagg aagctataaa ggaagacaac tccattcact gggaaagacc tcagaaaccc
     3601 atgaaatcag cgcgttctct gtacaaaccc caagcttcct ctgctgaagt agagatgaat
     3661 gcctatgtca tcttagctcg cctcactgcc cagtcagccc catcccctaa ggacctggct
     3721 ttgtcaatgg gcaccatcaa gtggctcaca aagcagcaga attcccgtgg tggcttctcc
     3781 tccacacagg acactgtggt ggccctcgat gctctgtcca aatacggagc agctactttt
     3841 tccaaaagcc aaaaaactcc ttcggtgacc gtccaatctt cagggtcatt tttccaaaag
     3901 ttccaagtgg acaacagtaa tcgtctgtta ctgcagcagg tctcattacc agacattcct
     3961 gggaactaca ccgtcagtgt gtcaggagaa ggatgtgtgt atgctcagac catgctgaga
     4021 tacaacctgc ccttggagaa gcagcagcct gcgtttgctc taaaggtgca gacagtaccc
     4081 ctgacttgta acaaccccaa aggccagaac agcttccaaa tctcactaga aatcagttac
     4141 acggggagcc gtccagcctc caacatggtg attgctgatg tgaagatgct ctctggtttc
     4201 atcccattga aaccaacagt gaagaagctt gaaagattag agcatgtaag cagaacagaa
     4261 gtgaccacca acaacgtcct gttatatttg gaccaggtaa ccaatcagac actgtccttc
     4321 tccttcatca ttcaacaaga catcccagta aagaacctgc agcctgccat tgtgaaagtg
     4381 tatgactact atgagacaga tgaagtggct tttgctgaat acagcagccc ctgcagctca
     4441 gacaaccaaa atgtttgaaa ctctaatctg cgaacaaggc attgctggaa tccccagtcc
     4501 agaaaacctt caagaaggtg atttgtgttt gtccctgaat tataaatatg gaacaacctt
     4561 ggtaaataaa tacataattc tagcaa
//
LOCUS       NM_001107481            4215 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus PNMA family member 8B (Pnma8b), transcript
            variant 1, mRNA.
ACCESSION   NM_001107481 XM_001064185 XM_218352
VERSION     NM_001107481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 10, 2025 this sequence version replaced NM_001107481.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643296.758.1, SRR26643429.1046.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4215              JAXUCZ010000001.1  86750391-86754605
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4215
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="PNMA family member 8B"
                     /db_xref="GeneID:308393"
                     /db_xref="RGD:1560435"
     exon            1..4215
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    386..388
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="upstream in-frame stop codon"
     CDS             407..2410
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="PNMA-like protein 2; PNMA-like 2; paraneoplastic Ma
                     antigen family member 8B; paraneoplastic Ma antigen
                     family-like 2"
                     /codon_start=1
                     /product="paraneoplastic antigen-like protein 8B"
                     /protein_id="NP_001100951.1"
                     /db_xref="GeneID:308393"
                     /db_xref="RGD:1560435"
                     /translation="MTMNLLQDWCKELEVEVHRALLITGIPERLQQADIEATLRPNLQ
                     PLGNYRLRTVRAVTKEKAQAALVEFGADFDHSAIPIHIRGENGIWKILSKDRGQDARV
                     LRQMRRLLLDERPMDDFREIAIPLVLEAQAQAKGLGKEAKKAGSSEGAARSGRRGRRG
                     GKRRSRSHKLTAQKGQKRSRGGRRARSESEDSSDDSLGIVIEEIYAEDLSVDEDQRAL
                     YATLQAAAKELTKKWAFRGDQDEGDGPREFLALVTVTDKAKKEEIEKDLPGTESICLN
                     IKDEKSGVPDLVALLAVRDTPAVEVETEVEDDDEEDDDDDDDEDEDEDEDDDEDDDDD
                     GSDSESLENGEQGKEVMDSPEFVAIVAYTDPADPSAREEMLKIASVIETLGWGDKKDK
                     KDVLPQVLSVMAKDTSGPRVKVEEAGRQVDAMVLRKAEEDGNLLECISTLAEAENCPK
                     GKKSGLGLLRGWTAEGHQGGLLELVALLAAQDMVEAVREEEASRWGGGGSGGRKCDHS
                     QGGLSEVLAFLASQENLESNEESEEDSDTESEGDSEDTDSEESEPGDSVSKKPRAKRA
                     RTGSKGLAPAGATAVSTGSRARKTRRGGRGRGRGVTPEKKAGSGASTEDHAGNNKKKK
                     KKGSAGAGARVRAGEAKGQPAAVPKSTRGKKARRGPRRAPKCR"
     misc_feature    407..>748
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="Region: PNMA; pfam14893"
                     /db_xref="CDD:464357"
     misc_feature    407..>748
                     /gene="Pnma8b"
                     /gene_synonym="Pnmal2; RGD1560435"
                     /note="Region: PNMA; pfam14893"
                     /db_xref="CDD:464357"
ORIGIN      
        1 gttccgcagc ggccccgctg agcgtctaga cctggctacg cgcttcgctc cagactccgc
       61 gggagcacag gcgagccgct gctcccaccc accccacgcc caccaggtgc attgattgcc
      121 gtcctcctgt accccaccag ccgcgtccag tcgtctgggt tgtcagggac aaagggagga
      181 acaacccggg ccagcccgga gaacgtacac gtaagccccc tgcagaccct cggattgccc
      241 caggggaaga tcgttgcgtc gtcccgctag atagcaggta gctaaaaccc agagccccaa
      301 acccgagtct ggactctcac cctgcgggtg gcctttccag agtgggtttg acctagcctt
      361 tctcgggctc cctcccgccc aagattagcc tctgccaggc agcgccatga ctatgaacct
      421 tctgcaagat tggtgtaagg agctggaagt ggaggtgcac agggccctcc tgatcacggg
      481 catccccgag cgcctgcagc aggcggacat cgaagctacc ctgaggccga acttgcagcc
      541 cctgggcaac tacaggcttc gaactgtgag agccgtgacc aaggagaagg ctcaggccgc
      601 ccttgttgaa tttggggccg acttcgatca ctctgccata cctatccaca ttaggggaga
      661 gaatgggatc tggaaaatcc tgagtaagga ccgcgggcaa gatgcgcggg tccttaggca
      721 gatgaggcgc ctgttgctgg atgaaaggcc catggatgac ttcagagaaa ttgccatccc
      781 tctggtattg gaggcccagg cccaggccaa gggattaggg aaggaggcca agaaagctgg
      841 ctcctctgaa ggggcagcta ggagcggccg tcggggccgt cggggaggta agcggcgatc
      901 cagaagccac aagttgacgg ctcagaaggg ccagaagagg agccggggag gacgccgagc
      961 caggagtgag tcggaagact cttctgatga cagcctgggt atcgtcatag aggagatcta
     1021 cgcagaggac ctgagcgtag atgaagacca gagagccctg tatgccacac tccaagcagc
     1081 cgccaaagag ctcaccaaga agtgggcctt tcggggtgac caggacgaag gagatggccc
     1141 ccgagagttt ttggcacttg tcacggtcac cgacaaagct aaaaaggaag agatagagaa
     1201 agaccttcct gggacagaat ctatttgctt aaacatcaaa gacgaaaaga gcggggtccc
     1261 tgatttagtc gcgctactgg ctgtgagaga tacccccgca gtggaggtag aaacagaagt
     1321 ggaggatgat gatgaagaag atgacgatga tgacgatgat gaagacgaag atgaagacga
     1381 agatgatgac gaagatgacg atgacgatgg ttccgacagc gagtctctgg aaaatggaga
     1441 gcaagggaag gaagtaatgg acagccccga gtttgtggct atcgtggctt atacagaccc
     1501 cgccgacccg tctgccagag aagaaatgct gaaaatcgct tctgtgattg agaccctcgg
     1561 ttggggcgat aaaaaagaca aaaaagatgt ccttcctcaa gtcctgtccg tcatggccaa
     1621 ggacacctct gggcccaggg tgaaggtaga agaggcaggt cgccaggtgg acgccatggt
     1681 tctgaggaag gcagaggaag atgggaatct tctggaatgt atttccacct tggctgaagc
     1741 agagaactgc cctaaaggaa agaaatctgg gctaggtctc ctcagaggct ggaccgctga
     1801 gggccaccag ggtggcctct tggagctggt ggcactcctg gctgctcaag atatggtgga
     1861 agctgtgaga gaggaagaag ccagcaggtg gggcggtggt ggaagtggtg gccggaagtg
     1921 tgatcacagc caaggtggtt tatccgaggt cctggctttc ctggcctccc aggagaatct
     1981 cgaatccaac gaggaatcgg aggaagattc agacacagag tcagagggag attccgagga
     2041 cactgacagc gaagagtcag aacctggtga cagcgtgtcc aagaagccgc gcgccaagag
     2101 agcgcgcacc ggctccaaag gcttggcacc ggccggcgcc accgcggtct ccaccgggtc
     2161 ccgggcacgc aaaacccgca ggggtggccg cggtcgtggc cgcggtgtca ccccagagaa
     2221 gaaagcgggg agcggggctt caaccgagga ccatgcgggg aacaacaaaa agaagaagaa
     2281 gaagggatcc gcaggcgccg gggcccgtgt cagggctggt gaggccaagg gacagccagc
     2341 tgctgttccc aagtctaccc gcggaaagaa agcacgcagg ggcccaaggc gggcgcccaa
     2401 atgccgttag tgccgcagat gtcactacga gccccgtctc ttgtgtgtgg acttccccct
     2461 tcccgtttcc tcctattctc tcttctccct gcagcttccc tctcgcttaa ccgcgtgcat
     2521 ttgctttgtg ctccgctgtg tccctggctg gctatggccg gtgcccagct ttccctctca
     2581 gttccatgaa cagatggcat gagcgatcat tatggctgca gcctagatac aaggaaaaga
     2641 gacaaggcac tcggatgcag tggccggtga gtgcggggga gaaatggact tgaagacacc
     2701 gaggggctct gctctacctc cggagccctc tccccccgcc ccgcgtgagt gtgcgtgagt
     2761 gtctgacact cctgccggcc cattctttca ggcacctgtt tctggcggag ccgttgggat
     2821 ctactgggag ccacctctgg ccctgacggg gcattaggga gaagcaagag tgatgggcac
     2881 aatgcgtatt aggggatttt ggaagggtta agggccgtgt gtgtgtgtgt gtgtgtgtgt
     2941 gtgtgtgtgc gtgcttgcgc aagcgcgtgt gtgcgcatgt gtgtctgcgc tcgcgcgccc
     3001 gtgtgtacat gcgtgtgtgt gtgtgtgcgc gtgcgcgcgc gtgcgctcct gcgcgtgtgc
     3061 gcgcgtttat gtgtgtgtat tttgagggaa aggtattcca taaatgcaag tctgaggggg
     3121 ctgggagctg gaggaggaat aaaaatggaa ggagaggagg ggaatgttgg ggggggactg
     3181 gggaggaggg agaatagggg aaccaggagg aggaaggaag gaaggcgttt gcattagccc
     3241 atcctcctga ggctttgcag ttgggaacga gggggaagct aagcctcccc ccaccagccc
     3301 gtgtccacag gttgaactgg taatatactg ccaatatgtt ctgatttgga aaacttacat
     3361 gaaatccaga tttccagctt tctgggcaag ccttgcccct ccgactgtgg tgccccagct
     3421 gtcagtggcc acccctcagc tgtttgccct tgtaactctt gacttaatgt aacaatggag
     3481 tcccttgttc accccccccc actccaactg tgtgcagtaa agaccccaga tccccttaaa
     3541 gggtcaagtg tccctattgt aggaagcagt tgctgtgccc caccctggca tcattagtcc
     3601 cccagtaaag cctgtctgat gctggccact ctccagccct cagctgtccc tgaaaacagc
     3661 cgctttagct gtgtgttttc ctgtagtgct acgcgccaga agccctggcc gcctagttct
     3721 gtgtttcgat gtgtagataa tgctttgccc tgcacagcac tttgcaccct cttgttcgtg
     3781 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttttcaac tttctatccc
     3841 caggaagtga ccagttcgtg gtacctggac cttttaggat gtaacagaag ttctgaccag
     3901 cctcacaccc agaccgaact gtccagctcc tcagtgggga catacagaaa ctgcaggggg
     3961 catgggtacc tctttgtact cagaggcagc cccactcctt gcttcccagg accagggatg
     4021 atgacgggac agatggagaa gcaggccagg ggagccttcg gctggagagg aaaccccact
     4081 tcatggtggc tgatggactt ggggtgtggt ggctggggag ggccccacat gtcacttccc
     4141 cttgcatagt tacaggtacc tgtcctcgtg tgctgtgtga tccgggatcc tcaaatgaag
     4201 caatgaagca tctta
//
LOCUS       NM_001100749            2633 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus max dimerization protein 1 (Mxd1), mRNA.
ACCESSION   NM_001100749 XM_001074696 XM_342716
VERSION     NM_001100749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Lin,S.Y. and Elledge,S.J.
  TITLE     Multiple tumor suppressor pathways negatively regulate telomerase
  JOURNAL   Cell 113 (7), 881-889 (2003)
   PUBMED   12837246
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Oh,S., Song,Y.H., Yim,J. and Kim,T.K.
  TITLE     Identification of Mad as a repressor of the human telomerase
            (hTERT) gene
  JOURNAL   Oncogene 19 (11), 1485-1490 (2000)
   PUBMED   10723141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_342716.3, XM_001074696.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.20065.1,
                                           SRR26643298.23889.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000004.1  120674924-120675129 c
            207-306             JAXUCZ010000004.1  120674522-120674621 c
            307-336             JAXUCZ010000004.1  120669054-120669083 c
            337-451             JAXUCZ010000004.1  120658761-120658875 c
            452-611             JAXUCZ010000004.1  120657115-120657274 c
            612-2633            JAXUCZ010000004.1  120654731-120656752 c
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2633
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="max dimerization protein 1"
                     /db_xref="GeneID:362391"
                     /db_xref="RGD:1564525"
     exon            1..206
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..832
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /codon_start=1
                     /product="max dimerization protein 1"
                     /protein_id="NP_001094219.1"
                     /db_xref="GeneID:362391"
                     /db_xref="RGD:1564525"
                     /translation="MATAVGMNIQLLLEAADYLERREREAEHGYASMLPYSSKDRDAF
                     KRRNKPKKNSTSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAK
                     LHIKKLEDCDRKAVHQIDQLQREQRHLKRRLEKLGAERTRMDSVGSVVSSERSDSDRE
                     ELDVDVDVDVDVDVDVDVESTDYLNGDLGWSSSVSDSDERGSMQSLGSDEGYSSASVK
                     RAKLQDGHKAGPGL"
     misc_feature    302..541
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in protein Max-associated protein 1 (Mad1) and
                     similar proteins; Region: bHLHzip_Mad1; cd18931"
                     /db_xref="CDD:381501"
     misc_feature    302..541
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in protein Max-associated protein 1 (Mad1) and
                     similar proteins; Region: bHLHzip_Mad1; cd18931"
                     /db_xref="CDD:381501"
     misc_feature    order(314..319,326..331,335..340,350..352,407..415)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381501"
     misc_feature    order(314..319,326..331,335..340,350..352,407..415)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381501"
     misc_feature    order(347..352,356..373,377..382,416..418,425..427,
                     437..439,443..451,455..460,464..469,476..478,488..490,
                     497..502,506..511,518..523,527..532)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:381501"
     misc_feature    order(347..352,356..373,377..382,416..418,425..427,
                     437..439,443..451,455..460,464..469,476..478,488..490,
                     497..502,506..511,518..523,527..532)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:381501"
     misc_feature    order(347..349,356..361,365..370,377..382,416..418,
                     425..427,437..439,443..451,455..460,464..469,476..478,
                     488..490,497..502,506..511,518..523,527..532)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381501"
     misc_feature    order(347..349,356..361,365..370,377..382,416..418,
                     425..427,437..439,443..451,455..460,464..469,476..478,
                     488..490,497..502,506..511,518..523,527..532)
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381501"
     exon            207..306
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..336
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..451
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..611
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..2633
                     /gene="Mxd1"
                     /gene_synonym="Mad-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggcggtg gcggctgggc tccgggctcc gtgctgtccc atcgctgccc cttctggctg
       61 gccagcgcgg cagctcctcg gtgttcccgg ccggccgccc gcgggcacgg agaggcagcc
      121 cgccgggtgc aggatggcga cagccgtcgg gatgaacatc cagctgctgc tggaggcggc
      181 cgactacctg gagcggcggg agagagaagc tgaacatggg tatgcctcca tgttgccata
      241 cagtagcaag gacagagatg ccttcaaacg gagaaacaag cccaagaaga acagcaccag
      301 tagcagatca actcacaatg agatggagaa gaacaggcgt gctcacctcc gcctgtgcct
      361 agagaagctg aaggggctgg taccgctggg ccccgagtca agccgacaca ccaccctgag
      421 tttgctgaca aaagccaaat tgcacataaa gaaacttgaa gattgtgaca ggaaagctgt
      481 ccaccaaata gaccagcttc agcgggagca gcggcacctg aagcggcggc tggagaagct
      541 gggtgctgag aggactcgga tggacagcgt gggctctgtg gtgtcttcag agcgctccga
      601 ctctgacagg gaagagctgg acgtggacgt ggacgtggac gtggatgtgg atgtggatgt
      661 ggacgtggag agcacagact acctcaatgg ggacctgggc tggagcagca gcgtgagtga
      721 ctcggacgag cggggcagca tgcagagcct gggcagtgat gagggctact ccagtgccag
      781 tgtcaaaaga gccaagctcc aggacggcca caaggcaggt cccgggctat aggagagggc
      841 ccagccgtct ctccacctca cctggttagg tagtgtacca gacctgtcca gatgcccttg
      901 cacgcaaacc tcatgtacca ccttgaccaa tatcagctct gtccactttg cagaaagcac
      961 atagggttgt ggtcttgagt gtgatcagta gcttctctgt ccatacatgt cgacgccgag
     1021 agactgtaca tcccagtcag ttcaaagcac ccaagagtcc ttagcccaag cgaatctcac
     1081 ctctcagccg cccccgtgca ctgtcctgca gctgacgagg tctccttagt tttctgactc
     1141 ccgatggtac tcgcccagga gagaagtaca agctttgtct ggtacatagg aaaccgcagc
     1201 aaacaacttc tcaaagggaa ctcagtctca cgaaccccac aggaagcttt ggaagccaaa
     1261 ccgaagagca ctgagaggcc aggagcccct ccagccctgc ctcggcccag ccgcgtgcgg
     1321 tgctgcggcc ctgcttaaga gcaggcactc ggcagctcag gagaaccgtg tgccctgtgt
     1381 gctgctctgg ggcctagcca tgtgcccgag tctgctgatg ctccttgtct ctggaacatt
     1441 gtcctacctc agagatagat gagatctcca tcgtccacgt aacggaagtg actgcttctt
     1501 catccccatg gtcccctcca cccgcatccc tgtcgaattc ccagcaataa ctgagttttg
     1561 gcactggctg agctggtagc cactgtctgt gagagaaaga ggccacattt cttctctgtg
     1621 gcaagtgaac aggagggtct ccatgtcacc agaaccttcc tgctaaggta gttttgaaca
     1681 ccctagaagt ttccttctgg agacttccag gtctacagct taaaaggatg atttttcccc
     1741 ccttgtggca tttttattta aggtaaacca gagcacacac gtatgtaaat aagacacaca
     1801 acacctataa atactattta ttcattttat ataaactaac gtaatgcaat ataaattcct
     1861 atgactgctt ttatagatgt tctagaaact ttgtacgtag ctgtctacaa aattcattcc
     1921 cctgaatatt ttcgcattcg gattttgagg ttttcacact ctggtgagtc tttttcacga
     1981 agtctgaacc atctgtaaat tcctcgctct gcggctgagc ctgtgtcacc aggtaatggg
     2041 acactcctga gactcacggt gtcacctaag ggctccacag ctgactcggc agcacgcaac
     2101 tacacagtca cactccccct cctcaagtcc aaacacgcct cggcagagag agcggtccca
     2161 gccccacaag gtcaccatgg acgccatgtg ctccttgatg gccccaaagt cctgtttcag
     2221 atttttcgtt ttttcttttc acttgttgga gtgttttcca aataccagct ggagattagc
     2281 acagaagcac agcttggatt ggatgccatt agcatttgca gaaccctttc cagagtctga
     2341 cagggctggt gttccgtccc cttggatccc tacctgctag acctcgaggg catcgtatct
     2401 gttcactgca cccaaggcca tcggaaagtc aggaccacgg gagaggctgt gggctgcaca
     2461 gggggaggga acaaaacttg tacacatatt tatttcactt agaaggtatc tgaaagatgc
     2521 catcattccc tgtgttttca ttgttgcacc tttgagttaa actgcttttt tttttttttg
     2581 gttgaaatat gaagtgtact gtcccaacat aaaacagtga ttatttgact ttt
//
LOCUS       NM_012711               3938 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus integrin subunit alpha M (Itgam), mRNA.
ACCESSION   NM_012711
VERSION     NM_012711.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Wang,Y., Pi,Y., Hu,L., Peng,Z., Hu,H., Zhao,J., Zhou,Y. and Wang,D.
  TITLE     Proteomic analysis of foot ulcer tissue reveals novel potential
            therapeutic targets of wound healing in diabetic foot ulcers
  JOURNAL   Comput Biol Med 159, 106858 (2023)
   PUBMED   37087778
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Atcha,H., Meli,V.S., Davis,C.T., Brumm,K.T., Anis,S., Chin,J.,
            Jiang,K., Pathak,M.M. and Liu,W.F.
  TITLE     Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to
            Mechanical Cues
  JOURNAL   Front Immunol 12, 689397 (2021)
   PUBMED   34630381
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Lokki,A.I., Teirila,L., Triebwasser,M., Daly,E., Bhattacharjee,A.,
            Uotila,L., Llort Asens,M., Kurki,M.I., Perola,M., Auro,K.,
            Salmon,J.E., Daly,M., Atkinson,J.P., Laivuori,H., Fagerholm,S. and
            Meri,S.
  CONSRTM   Finnpec
  TITLE     Dysfunction of complement receptors CR3 (CD11b/18) and CR4
            (CD11c/18) in pre-eclampsia: a genetic and functional study
  JOURNAL   BJOG 128 (8), 1282-1291 (2021)
   PUBMED   33539617
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Zhou,M., Wang,X., Shi,Y., Ding,Y., Li,X., Xie,T., Shi,Z. and Fu,W.
  TITLE     Deficiency of ITGAM Attenuates Experimental Abdominal Aortic
            Aneurysm in Mice
  JOURNAL   J Am Heart Assoc 10 (7), e019900 (2021)
   PUBMED   33749307
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Shi,F.J., Xie,H., Zhang,C.Y., Qin,H.F., Zeng,X.W., Lou,H.,
            Zhang,L., Xu,G.T., Zhang,J.F. and Xu,G.X.
  TITLE     Is Iba-1 protein expression a sensitive marker for microglia
            activation in experimental diabetic retinopathy?
  JOURNAL   Int J Ophthalmol 14 (2), 200-208 (2021)
   PUBMED   33614447
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Choi,M., Rabb,H., Arnaout,M.A. and Ehrlich,H.P.
  TITLE     Preventing the infiltration of leukocytes by monoclonal antibody
            blocks the development of progressive ischemia in rat burns
  JOURNAL   Plast Reconstr Surg 96 (5), 1177-85 (1995)
   PUBMED   7568496
REFERENCE   7  (bases 1 to 3938)
  AUTHORS   Coombe,D.R., Watt,S.M. and Parish,C.R.
  TITLE     Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic
            progenitor cells to stromal cell elements via recognition of
            stromal heparan sulfate
  JOURNAL   Blood 84 (3), 739-752 (1994)
   PUBMED   8043862
REFERENCE   8  (bases 1 to 3938)
  AUTHORS   Seekamp,A., Mulligan,M.S., Till,G.O., Smith,C.W., Miyasaka,M.,
            Tamatani,T., Todd,R.F. 3rd and Ward,P.A.
  TITLE     Role of beta 2 integrins and ICAM-1 in lung injury following
            ischemia-reperfusion of rat hind limbs
  JOURNAL   Am J Pathol 143 (2), 464-472 (1993)
   PUBMED   8102031
REFERENCE   9  (bases 1 to 3938)
  AUTHORS   Mulligan,M.S., Varani,J., Warren,J.S., Till,G.O., Smith,C.W.,
            Anderson,D.C., Todd,R.F. 3rd and Ward,P.A.
  TITLE     Roles of beta 2 integrins of rat neutrophils in complement- and
            oxygen radical-mediated acute inflammatory injury
  JOURNAL   J Immunol 148 (6), 1847-1857 (1992)
   PUBMED   1347308
REFERENCE   10 (bases 1 to 3938)
  AUTHORS   Tamatani,T., Kotani,M. and Miyasaka,M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF268593.1, SRR26643298.5540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000001.1  192089592-192089651
            61-166              JAXUCZ010000001.1  192091693-192091798
            167-270             JAXUCZ010000001.1  192097657-192097760
            271-341             JAXUCZ010000001.1  192099374-192099444
            342-459             JAXUCZ010000001.1  192099581-192099698
            460-590             JAXUCZ010000001.1  192104302-192104432
            591-736             JAXUCZ010000001.1  192104802-192104947
            737-890             JAXUCZ010000001.1  192106160-192106313
            891-1041            JAXUCZ010000001.1  192107792-192107942
            1042-1115           JAXUCZ010000001.1  192108629-192108702
            1116-1245           JAXUCZ010000001.1  192109163-192109292
            1246-1388           JAXUCZ010000001.1  192109545-192109687
            1389-1529           JAXUCZ010000001.1  192117910-192118050
            1530-1739           JAXUCZ010000001.1  192118131-192118340
            1740-1870           JAXUCZ010000001.1  192123450-192123580
            1871-2034           JAXUCZ010000001.1  192123664-192123827
            2035-2189           JAXUCZ010000001.1  192134382-192134536
            2190-2321           JAXUCZ010000001.1  192134629-192134760
            2322-2395           JAXUCZ010000001.1  192134911-192134984
            2396-2537           JAXUCZ010000001.1  192135210-192135351
            2538-2657           JAXUCZ010000001.1  192135438-192135557
            2658-2737           JAXUCZ010000001.1  192136108-192136187
            2738-2821           JAXUCZ010000001.1  192136947-192137030
            2822-2897           JAXUCZ010000001.1  192137369-192137444
            2898-3005           JAXUCZ010000001.1  192137919-192138026
            3006-3089           JAXUCZ010000001.1  192138136-192138219
            3090-3203           JAXUCZ010000001.1  192138323-192138436
            3204-3305           JAXUCZ010000001.1  192138518-192138619
            3306-3416           JAXUCZ010000001.1  192138837-192138947
            3417-3938           JAXUCZ010000001.1  192139422-192139943
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3938
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin subunit alpha M"
                     /db_xref="GeneID:25021"
                     /db_xref="RGD:2926"
     exon            1..60
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..3488
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha-M; integrin, alpha M"
                     /codon_start=1
                     /product="integrin alpha-M precursor"
                     /protein_id="NP_036843.2"
                     /db_xref="GeneID:25021"
                     /db_xref="RGD:2926"
                     /translation="MTLKFLLVTVLTLCHGFNLDTENPMTFQENARGFGQSVIQLGET
                     RVVVAAPQEVKAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQL
                     LACGPTVHQNCKENTYVNGLCYLFGSNLLRKPQQFPEALRGCPQQESDIAFLIDGSGS
                     INSIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPI
                     RQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAE
                     EAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFA
                     IEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKATFINT
                     TRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKG
                     SQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGRARWQCEAI
                     LHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTP
                     HSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATM
                     EFSPKNLARSVFACQEEVVKNKDAGEVRVCLHVRKNTKDRLREGDIQSTVTYDLALDP
                     GRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGE
                     PLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSIRVNTLVVGDSR
                     DFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQG
                     VLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVVTSENNVSRTDKTES
                     QLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLGQRSFPVSVVFWI
                     PVQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQ
                     CDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFV
                     KAQTETKVEPYKVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQ
                     DGPPQ"
     sig_peptide     33..80
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    477..1004
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; Region:
                     vWA_integrins_alpha_subunit; cd01469"
                     /db_xref="CDD:238746"
     misc_feature    477..1004
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; Region:
                     vWA_integrins_alpha_subunit; cd01469"
                     /db_xref="CDD:238746"
     misc_feature    order(477..479,483..485,546..548,786..788,792..794,
                     879..881,969..971)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     misc_feature    order(477..479,483..485,546..548,786..788,792..794,
                     879..881,969..971)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     misc_feature    order(498..500,504..506,510..512,705..707,804..806)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="metal ion-dependent adhesion site (MIDAS); other
                     site"
                     /db_xref="CDD:238746"
     misc_feature    order(498..500,504..506,510..512,705..707,804..806)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="metal ion-dependent adhesion site (MIDAS); other
                     site"
                     /db_xref="CDD:238746"
     misc_feature    order(504..512,516..518,705..707)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     misc_feature    order(504..512,516..518,705..707)
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     misc_feature    1389..1559
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1389..1559
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1578..1739
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1578..1739
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1773..>1847
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1773..>1847
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha (beta-propellor repeats); Region:
                     Int_alpha; smart00191"
                     /db_xref="CDD:214549"
     misc_feature    1875..3125
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha; Region: Integrin_alpha2; pfam08441"
                     /db_xref="CDD:462478"
     misc_feature    1875..3125
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha; Region: Integrin_alpha2; pfam08441"
                     /db_xref="CDD:462478"
     misc_feature    3414..3452
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha cytoplasmic region; Region:
                     Integrin_alpha; pfam00357"
                     /db_xref="CDD:459778"
     misc_feature    3414..3452
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha cytoplasmic region; Region:
                     Integrin_alpha; pfam00357"
                     /db_xref="CDD:459778"
     exon            61..166
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            167..270
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            271..341
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            342..459
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            460..590
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            591..736
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            737..890
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1041
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1115
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1245
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1388
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1529
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1739
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1870
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2034
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2189
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2321
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2395
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2537
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2657
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2737
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2821
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2897
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3005
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3089
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3203
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3305
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3416
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3938
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacatctcc tagggttttg ttcctttcag tcatgactct taaatttctt ctggtgacag
       61 tcctaacctt gtgtcatggc ttcaatttgg acactgaaaa tcccatgacc ttccaagaga
      121 atgcaagagg cttcgggcag agtgtgatcc agcttggtga aacccgagtg gttgttgcag
      181 ccccccagga ggtaaaggcg gttaaccaga caggtgccct ctaccagtgt gactacagca
      241 caaaccggtg cgaccccatt cccctgcaag tacctccaga ggctgtgaat atgtccttgg
      301 gcctgtccct ggctgctact accgtccctc cacagctgct ggcttgtggc cccacagtac
      361 accagaactg caaggagaac acttacgtca atggattgtg ctacctattc ggctccaacc
      421 tgctgaggaa gccccagcag ttcccagagg ctctcagagg atgtcctcag caggagagcg
      481 acattgcctt cttgattgac ggctccggta gcatcaacag catcgacttt cagaagatga
      541 aggaatttgt ctcaactgtg atggaccagt tccaaaagtc taaaaccttg ttctctttga
      601 tgcagtactc tgatgaattc cggactcact tcaccttcaa tgatttcaag agaaaccctg
      661 acccaaaatc acatgtgaga cccataaggc agctgaatgg aaggacaaaa actgcctcag
      721 ggatccgtaa agtagtgaga gaactgtttc agaaaatcaa tggggcccgg gacaatgccg
      781 cgaagatcct agttgtcatc acagacggag aaaagtttgg tgacccccta aattatgagg
      841 atgtcattcc tgaggcagag gaagcaggga tcattcgcta cgttattggg gtgggaaacg
      901 ccttccacaa accacagtcc cgcagagagc ttgacaccat cgcgtctaag ccagctggtg
      961 atcacgtgtt ccaagtggac aactttgaag ctctgaatac cattcggaac cagctccagg
     1021 aaaagatctt tgcaattgag ggcacccaga caggaagtac cagctccttt gagcatgaga
     1081 tgtctcaaga aggctttagc gctgccatta cctctaacgg tcccttgctg ggctccgtgg
     1141 ggagctttga ctgggcaggt ggagccttcc tgtatccatc aaaggataaa gccactttca
     1201 tcaacacaac cagaatagat tcagacatga acgatgctta cttgggttat gcttctgcag
     1261 tcatctcgag gaaccgcgtc caaagcttgg ttttaggggc acctcgatat cagcatatcg
     1321 gcctggtggt gatgttcaag cagaatttcg gtgcctggga gccccacact gatatcaagg
     1381 gcagccagat cggctcttat tttggggcct ccctctgttc tgtggacatg gacgctgatg
     1441 gcaataccaa cttgatcctc attggggccc ctcatcacta tgagaagacc cgagggggcc
     1501 aggtgtcagt gtgccccttg cctaggggga gagcacggtg gcagtgtgaa gctattctcc
     1561 atggcgatca gggccatcca tggggtcgct ttggggcagc attgacagtg ctgggagatg
     1621 tgaatggaga caaactgaca gatgtggcca ttggggcccc aggagagcag gagaatcagg
     1681 gtgctgtcta catttttcat ggagcatcag tagccagcat cagtacccct cacagccagc
     1741 ggatcgcagg cgcccgcttc tcccccgggc tccagtactt tgggcagtct ctgagtgggg
     1801 gcaaggatct cacaatggac ggcctgatgg acttggctgt gggggcgcag gggcgtcttc
     1861 tgctgatcag agcccagcct gtgctgagac tggaggcaac catggaattc agccccaaga
     1921 atctagcaag gagtgtgttt gcgtgtcaag aagaagtagt caaaaacaag gatgctgggg
     1981 aggtcagagt ctgcctccat gtccgcaaga acaccaagga caggctgcga gaaggagaca
     2041 tccagagcac tgtcacttat gacctggctt tagaccccgg ccgctcagtt gtccgagcct
     2101 tctttgatga aacaaagaac ggcatactca ggcgcatccg ggtctttgga ttgacacaga
     2161 aatgtgaaac cctgaagcta attttaccgg actgtgtgga caactcagtg agtcccatca
     2221 tcctgcgcct taattacaca ctggttgggg agcccttgcg gtcctctagg gaccttcggc
     2281 cagttctggc tatggaggct cagaggatct tcacagctat gtttcccttt gagaagaatt
     2341 gtggcaatga caccatttgc caggatgatc tcagcatcac cgtgagttcc atacgcgtga
     2401 acactttggt ggtgggagac tcccgggact ttgacgtgag tgtgactctg agaaatgatg
     2461 gcgaggattc ctatgggacc aaggttacct gttattaccc atctggcttg tcttaccgga
     2521 aggtgtcagc aagccagaac cagttctcca agaagccttg gcgtgtgata gctgagccca
     2581 gttcttctga agggcaaggg gttctgaaga gcaccatctg ggatataaac catcccatct
     2641 ttcccgctaa ttctgaggtc acgtttaatg tcacatttga tgtggactct gatgcctccc
     2701 ttgggaacaa actgctcctc aaggtcgttg tgaccagcga gaacaacgtg tccaggaccg
     2761 acaaaactga gtctcagttg gagctgcctg tgaagtacgc catctacatg gtcgtcacca
     2821 gtggtgagag ttctatcaaa tatctcaact tcacagcttc agagatgacc agtaaggtca
     2881 tacagcatca gtaccagttc aacaacctgg gccagaggag cttccctgtc agcgtggtct
     2941 tctggatccc tgtccagatc aacaaggtga ccatatggga tcctccccag gtcaccttct
     3001 cccagaacct ctcaagtgtc tgtcgcactg agcagaaatc cccctctcac tccaagttcc
     3061 aggatgagct tgaaaggacc ccagtgctga actgctctgt tgcagtctgc aagagaatcc
     3121 agtgtgacat cccttccttc aacagtaaag aaatattcaa cgtcaccctc cagggcaatc
     3181 tgctatttga ctggtacatc gagacttctc acgaccacct cctgcttgtg agcactgccg
     3241 agatcctctt taacgactcc gcatttgccc tacttccggg gcaggagacg tttgtgaagg
     3301 ctcagacaga gaccaaagtg gagccatata aagttcacaa ccctgtacca ctcattgtgg
     3361 gcagctccgt cggaggcctg gtgctcttgg ctctcatcac tgctggcctg tacaagcttg
     3421 gctttttcaa acgacagtac aaggacatga tgaatgaagc cgctccccaa gatggccccc
     3481 ctcagtaatg gcctttgttc catggagtga cctctccaac aacaagcagg tctagacggt
     3541 cagaccaaca gcgaggctgg tggacagaca tgtcctttag aagactgttg ccgtgacgtc
     3601 ttatacagaa atggagtttc tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggaa
     3661 gtcagaacag caaagaacag cacgcgcgcg cacacacaca cacacacaca cacacacaca
     3721 cggttttaaa caagtggtag cactttttta ctgttatgca tattgtcttt ttattaatat
     3781 gctcaaataa ttttatataa gttataaagt agctcagagt attcccttgt gatttaacat
     3841 atttaacatt taatgtaatc tcctttggac atattatttc cagccatttg ctattgtgaa
     3901 caatgctgaa ttaataaatt gggtatatct aattttta
//
LOCUS       NM_012524               2673 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein alpha (Cebpa),
            transcript variant 1, mRNA.
ACCESSION   NM_012524
VERSION     NM_012524.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Wu,K., Huang,S., Zheng,F. and Liu,Y.
  TITLE     The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway
  JOURNAL   Acta Diabetol 60 (11), 1491-1503 (2023)
   PUBMED   37392202
  REMARK    GeneRIF: The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Xu,Z., Yao,X., Zhao,Y. and Yao,B.
  TITLE     C/EBPalpha involvement in microglial polarization via HDAC1/STAT3
            pathway aggravated sevoflurane-induced cognitive impairment in aged
            rats
  JOURNAL   PeerJ 11, e15466 (2023)
   PUBMED   37361037
  REMARK    GeneRIF: C/EBPalpha involvement in microglial polarization via
            HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive
            impairment in aged rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Lu,H., Chen,Y., Chen,Y., Huang,L. and Chen,L.
  TITLE     C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates
            Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of
            Vascular Smooth Muscle Cells in Aortic Dissection
  JOURNAL   J Immunol Res 2022, 7465353 (2022)
   PUBMED   36132983
  REMARK    GeneRIF: C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A
            Regulates Autophagy, Matrix Metalloproteinase Expression, and
            Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Duan,P., Wang,H., Yi,X., Zhang,H., Chen,H. and Pan,Z.
  TITLE     C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells
            and steroid-induced avascular necrosis of the femoral head by
            targeting the PPARgamma signalling pathway
  JOURNAL   Stem Cell Res Ther 13 (1), 342 (2022)
   PUBMED   35883192
  REMARK    GeneRIF: C/EBPalpha regulates the fate of bone marrow mesenchymal
            stem cells and steroid-induced avascular necrosis of the femoral
            head by targeting the PPARgamma signalling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Muller,C., Bremer,A., Schreiber,S., Eichwald,S. and Calkhoven,C.F.
  TITLE     Nucleolar retention of a translational C/EBPalpha isoform
            stimulates rDNA transcription and cell size
  JOURNAL   EMBO J 29 (5), 897-909 (2010)
   PUBMED   20075868
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Samuelsson,L., Stromberg,K., Vikman,K., Bjursell,G. and Enerback,S.
  TITLE     The CCAAT/enhancer binding protein and its role in adipocyte
            differentiation: evidence for direct involvement in terminal
            adipocyte development
  JOURNAL   EMBO J 10 (12), 3787-3793 (1991)
   PUBMED   1935900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Dec 18, 2013 this sequence version replaced NM_012524.2.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain and recognizes the
            CCAAT motif in the promoters of target genes. The encoded protein
            functions in homodimers and also heterodimers with
            CCAAT/enhancer-binding proteins beta and gamma. Activity of this
            protein can modulate the expression of genes involved in cell cycle
            regulation as well as in body weight homeostasis. The use of
            alternative in-frame non-AUG (CUG) and AUG start codons results in
            protein isoforms with different lengths. Differential translation
            initiation is mediated by an out-of-frame, upstream open reading
            frame which is located between the CUG and the first AUG start
            codons. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) can initiate translation from
            an upstream non-AUG (CUG) site, and also from three conserved
            downstream, in-frame AUG sites. The isoform (a) represented in this
            RefSeq results from translation initiation at the first AUG start
            codon. Isoform a has a shorter N-terminus, compared to isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.154041.1,
                                        SRR26643429.1696.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 10921906
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2673              JAXUCZ010000001.1  96896584-96899256
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="CCAAT/enhancer binding protein alpha"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
     exon            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    11..13
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative non-AUG (CUG) start codon;
                     isoform c"
     regulatory      97..114
                     /regulatory_class="uORF"
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10921906]"
                     /note="this uORF is predicted to encode a 5 aa peptide
                     (PMID:10921906)"
     CDS             122..1198
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="isoform a is encoded by transcript variant 1; C/EBP
                     alpha; CAAT/enhancer-binding protein, DNA-binding protein;
                     CCAAT/enhancer binding protein (C/EBP), alpha"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein alpha isoform a"
                     /protein_id="NP_036656.1"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
                     /translation="MESADFYEAEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPA
                     PPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGG
                     DFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQ
                     EPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQP
                     GHPTPPPTPVPSPHPAPAMGAAGLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKK
                     SVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRE
                     LDTLRGIFRQLPESSLVKAMGNCA"
     misc_feature    122..331
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Required to repress E2F1:TFDP1-mediated
                     transcription, to inhibit cell cycle and to induce
                     adipocyte differentiation.
                     /evidence=ECO:0000269|PubMed:11672531"
     misc_feature    122..286
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    164..166
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform d"
     misc_feature    281..337
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Required for interaction with TRIB1.
                     /evidence=ECO:0000250|UniProtKB:P49715"
     misc_feature    473..475
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform b"
     misc_feature    497..721
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Required to induce adipocyte differentiation.
                     /evidence=ECO:0000269|PubMed:11672531"
     misc_feature    596..598
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P49715; propagated from
                     UniProtKB/Swiss-Prot (P05554.3); acetylation site"
     misc_feature    647..706
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    659..703
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Required to functionally cooperate with SREBF1 in
                     promoter activation.
                     /evidence=ECO:0000250|UniProtKB:P53566"
     misc_feature    698..700
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P53566; propagated from
                     UniProtKB/Swiss-Prot (P05554.3); phosphorylation site"
     misc_feature    758..1051
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    785..787
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Phosphothreonine, by GSK3.
                     /evidence=ECO:0000250|UniProtKB:P53566; propagated from
                     UniProtKB/Swiss-Prot (P05554.3); phosphorylation site"
     misc_feature    797..799
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Phosphothreonine, by GSK3.
                     /evidence=ECO:0000250|UniProtKB:P53566; propagated from
                     UniProtKB/Swiss-Prot (P05554.3); phosphorylation site"
     misc_feature    809..811
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Phosphoserine, by GSK3.
                     /evidence=ECO:0000250|UniProtKB:P53566; propagated from
                     UniProtKB/Swiss-Prot (P05554.3); phosphorylation site"
     misc_feature    839..1195
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Interaction with FOXO1.
                     /evidence=ECO:0000250|UniProtKB:P53566"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    977..1060
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
     misc_feature    1070..1156
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="propagated from UniProtKB/Swiss-Prot (P05554.3);
                     Region: Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
ORIGIN      
        1 cgacccaaag ctgcgcgggc gcgggcgagt tggggtactg ggtgggcggc ggcgacagcg
       61 gcgccacgcg caggctggag gccgccgagg ctcgccatgc cgggagaact ctaactcccc
      121 catggagtcg gccgacttct acgaggcgga gccgcggccc ccgatgagca gccacctcca
      181 gagccccccg cacgcgccca gcaacgccgc ctttggcttt ccccggggcg cgggccccgc
      241 gccgccccca gccccacctg ccgccccgga gccgctgggc ggcatctgcg agcacgagac
      301 gtctatagac atcagcgcct acatcgaccc ggccgccttc aacgacgagt tcctggccga
      361 cctcttccag cacagccggc agcaggagaa ggccaaggcg gcggcgggcc ccgcgggtgg
      421 cggcggtgac tttgactacc cgggcgcccc ggcgggcccc ggcggtgcgg tcatgtccgc
      481 gggggcgcac ggaccccctc ccggctacgg ctgtgcggcg gccggctacc tggacggcag
      541 gctggagccc ctgtacgagc gcgtcggggc gcccgcgctg cggccgctgg tgatcaagca
      601 ggagccccgc gaggaggacg aggcgaagca gctggcgctg gccggcctct tcccctatca
      661 gcccccgccg ccgccgccgc caccgcaccc gcacgcgtct cccgcgcact tggccgcccc
      721 tcacttgcag ttccagatcg cacactgcgg ccagaccacc atgcacctgc agcctggcca
      781 ccctacgccg ccgccgacgc ccgtgcccag ccctcatccc gcgcctgcaa tgggtgctgc
      841 gggcctgccg ggccccgggg gctcgctcaa gggcttggct ggtccgcacc ccgacctccg
      901 caccggcggc ggcggcggcg gcggggccgg cgcgggcaag gccaagaagt cggtggataa
      961 gaacagcaac gagtaccggg tacggcggga acgcaacaac atcgcggtgc gcaagagccg
     1021 agataaagcc aaacagcgca acgtggagac gcagcagaag gtgttggagt tgaccagtga
     1081 caatgaccgc ctgcgcaagc gggtggaaca gctgagccgt gaactggaca cgctgcgggg
     1141 tatcttccgc cagctgcctg agagctcctt ggtcaaggcc atgggcaact gcgcgtgagg
     1201 cgcgcggctg cgggaccgcc ttgagccggc cccctggctg gggacccgga ggatggttta
     1261 gggtcgctgg atctctaggc tgcccggacc gtgcaagcca ggactaggag attctggtgt
     1321 cgcctgaaag cctggcctgc tccgcgtgtc ccctcccttc ctctgagccg gactcggtgc
     1381 gtctaagatg agagggagtc aggccgtggt ggtttctcct ttagaccgag agacttctcc
     1441 gcggagctga gctgggagcc cggcagtttt agtattaagg aagtaacctt gtgccttgga
     1501 tactcaaaac tcgctccttt tcctaccgag tagggggagc aaacatgtgc cttgatattt
     1561 tatttggagg attcctgctt cctccagagc tgcagcaggc ccccatgaga aaaatgaagg
     1621 gtgcaggccc agggcaggag gaagattcag gaagctgagg tcccagcagt ccctgagctg
     1681 cccctccgtc cctgtcctta gaggggaggg acttagggag ttggggattt gagtcttaaa
     1741 agtgtcccca cccctagtta catggagatg gagggttctt agccccttgc ttttcgctcc
     1801 tccatctaca ttcctccccc cacccccagc ttacaacagg ccaggtttcc ttggtgagtt
     1861 cgtggagaag ggggcaacac ccccagtcag accagaaggc tgagttgtga actggccatg
     1921 tggttaagca agtggtagaa gacagggacc ttagtttctg gtcttggggt ggaggatgaa
     1981 gacactggga ccatccgcct tgtgtgtact gtatgtcgcc agccgctgtt gctgaaggaa
     2041 cttgaagcat aatcgatcca tcccagaggg actggagtta tgacaagctt cccaaatatt
     2101 ttgctttatc atctgatatc aacacttgta tctggtctct gtgtcccagc ggtgccttgt
     2161 gcaatgtcag tgtgcgcgtc tatgctaaac caccatttta tttggtcttt tgttttgttt
     2221 tggttttgct ctgattcttg ccaaaatgag actcttcacg aacggccagg ggaaggggct
     2281 gagtgaggct ctcattcttt ttggtttagg gatgtttggt ttttttgttt tgttttgttt
     2341 tgttttgttt tctttcgcct cccagaggac caatgaaatg aagtgggctt ctccctctcc
     2401 cctagttttc caagggtgta tgtagttgtg ggtcttagct tccttcctcc ggctgagact
     2461 tatactggct tccccaccca cccaccccca tccccaaagg ccctggctct gggtctggaa
     2521 agaaggccac ctccagccaa tttgtacaca accctgccac tggaagcagg ggtggactgc
     2581 ttccttctct tctttttttg gggggagggg acacaaagtt tcatgctaga tgtcctatgt
     2641 attatatcta taatataaac atatcaaact caa
//
LOCUS       NM_001429871            2937 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus caspase 9 (Casp9), transcript variant 2, mRNA.
ACCESSION   NM_001429871 XM_039110693
VERSION     NM_001429871.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Bai,L., Yang,J., Zhang,H., Liao,W. and Cen,Y.
  TITLE     PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial
            ischemia/hypoxia-reperfusion injury via inactivation of apoptotic
            protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
  JOURNAL   Bioengineered 12 (1), 4385-4396 (2021)
   PUBMED   34304702
  REMARK    GeneRIF: PTB domain and leucine zipper motif 1 (APPL1) inhibits
            myocardial ischemia/hypoxia-reperfusion injury via inactivation of
            apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling
            pathway.
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Martin,S., Harrington,D.A., Ohlander,S., Stupp,S.I., McVary,K.T.
            and Podlasek,C.A.
  TITLE     Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog
            protein to the penis and cavernous nerve suppresses intrinsic and
            extrinsic apoptotic signaling mechanisms, which are an underlying
            cause of erectile dysfunction
  JOURNAL   Nanomedicine 37, 102444 (2021)
   PUBMED   34314869
  REMARK    GeneRIF: Peptide amphiphile nanofiber hydrogel delivery of Sonic
            hedgehog protein to the penis and cavernous nerve suppresses
            intrinsic and extrinsic apoptotic signaling mechanisms, which are
            an underlying cause of erectile dysfunction.
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Liu,H., Li,J., Jiang,C., Yuan,T. and Ma,H.
  TITLE     Cellular communication network factor 1 (CCN1) knockdown exerts a
            protective effect for hepatic ischemia/reperfusion injury by
            deactivating the MEK/ERK pathway
  JOURNAL   Clin Res Hepatol Gastroenterol 45 (5), 101737 (2021)
   PUBMED   34144219
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Zhuang,C., Ni,S., Yang,Z.C. and Liu,R.P.
  TITLE     Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide
  JOURNAL   Oxid Med Cell Longev 2020, 3240820 (2020)
   PUBMED   33224431
  REMARK    GeneRIF: Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Vu,C.C., Bortner,C.D. and Cidlowski,J.A.
  TITLE     Differential involvement of initiator caspases in apoptotic volume
            decrease and potassium efflux during Fas- and UV-induced cell death
  JOURNAL   J Biol Chem 276 (40), 37602-37611 (2001)
   PUBMED   11431480
  REMARK    GeneRIF: The activation of caspase-8, but not caspase-9, is
            necessary for Fas-induced apoptosis. Conversely, caspase-9, but not
            caspase-8, is important for UV-mediated shrunken morphology and
            apoptosis progression.
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Angelastro,J.M., Moon,N.Y., Liu,D.X., Yang,A.S., Greene,L.A. and
            Franke,T.F.
  TITLE     Characterization of a novel isoform of caspase-9 that inhibits
            apoptosis
  JOURNAL   J Biol Chem 276 (15), 12190-12200 (2001)
   PUBMED   11278518
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Zaidi,A.U., D'Sa-Eipper,C., Brenner,J., Kuida,K., Zheng,T.S.,
            Flavell,R.A., Rakic,P. and Roth,K.A.
  TITLE     Bcl-X(L)-caspase-9 interactions in the developing nervous system:
            evidence for multiple death pathways
  JOURNAL   J Neurosci 21 (1), 169-175 (2001)
   PUBMED   11150333
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   D'Sa-Eipper,C., Leonard,J.R., Putcha,G., Zheng,T.S., Flavell,R.A.,
            Rakic,P., Kuida,K. and Roth,K.A.
  TITLE     DNA damage-induced neural precursor cell apoptosis requires p53 and
            caspase 9 but neither Bax nor caspase 3
  JOURNAL   Development 128 (1), 137-146 (2001)
   PUBMED   11092819
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Kermer,P., Ankerhold,R., Klocker,N., Krajewski,S., Reed,J.C. and
            Bahr,M.
  TITLE     Caspase-9: involvement in secondary death of axotomized rat retinal
            ganglion cells in vivo
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 144-150 (2000)
   PUBMED   11146116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 30, 2024 this sequence version replaced XM_039110693.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.106984.1,
                                           SRR26643299.25378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000005.1  159391907-159391967
            62-461              JAXUCZ010000005.1  159394338-159394737
            462-496             JAXUCZ010000005.1  159397278-159397312
            497-673             JAXUCZ010000005.1  159398840-159399016
            674-763             JAXUCZ010000005.1  159399389-159399478
            764-911             JAXUCZ010000005.1  159400428-159400575
            912-1091            JAXUCZ010000005.1  159406720-159406899
            1092-1201           JAXUCZ010000005.1  159407383-159407492
            1202-2937           JAXUCZ010000005.1  159408606-159410341
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2937
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="caspase 9"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
     exon            1..61
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            62..461
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1294
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /EC_number="3.4.22.62"
                     /note="isoform 2 is encoded by transcript variant 2;
                     caspase-9-carboxyl-terminal divergent; 25 kDa caspase-9
                     dominant negative protein; caspase-9 dominant negative
                     form; apoptotic protease Mch-6; Ice-like apoptotic
                     protease 6; apoptotic protease activating factor 3;
                     caspase 9, apoptosis-related cysteine peptidase"
                     /codon_start=1
                     /product="caspase-9 isoform 2"
                     /protein_id="NP_001416800.1"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
                     /translation="MGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLT
                     PETPRPVDIGSGRAHDVCTPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTR
                     IGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHG
                     CQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGF
                     EVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSW
                     RDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEKGVYKQIPGCFNFLRKKLF
                     FKTS"
     misc_feature    497..1285
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    497..1285
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    order(581..583,755..757,896..898,917..919,1097..1114,
                     1124..1129)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(581..583,755..757,896..898,917..919,1097..1114,
                     1124..1129)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(752..754,902..904)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(752..754,902..904)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(920..922,1052..1057,1076..1078,1085..1087,
                     1094..1096,1163..1165,1187..1189,1205..1207,1235..1237,
                     1250..1255,1259..1261,1268..1273)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(920..922,1052..1057,1076..1078,1085..1087,
                     1094..1096,1163..1165,1187..1189,1205..1207,1235..1237,
                     1250..1255,1259..1261,1268..1273)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(923..925,1049..1051)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(923..925,1049..1051)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     exon            462..496
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            497..673
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            674..763
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            764..911
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1091
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1201
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..2937
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggactggt gaagcggtga cggggccttc ggagctgagg tggctgcgga ggtggagccg
       61 acgggcaggc tctgggtctc ggcgggatca ggccaggcag ctggtcatag atcttgagac
      121 tcgagggagg caggcccttc ctcgcttcat ctcctgctta gaggacacag gccaaggctc
      181 tctggcttca ttcttgcaaa gcagtgggca agcagccaag caggatccag aagctgttac
      241 acccctagac cacctggtgc ctgtggtcct gggaccaatg ggactcaaat caaaggagca
      301 gaaagtagtg aagctggacc catctcagcc tgccttggga aacctcaccc cagtggtgct
      361 ggggccggaa gagctctggc ctactcggct caggccagag gttctcacac cagaaacacc
      421 caggccggtg gacattggtt ctggcagagc tcatgatgtc tgtactccag ggaagatcga
      481 gagacatgca gatatggcat acaccctgga ctcggatccc tgtggccact gcctcatcat
      541 caacaacgtg aacttctgcc cttcctcagg gctcagcaca cgcattggct cccacgtgga
      601 ctgtgagaag cttcagcacc gcttctgctg gctgcgcttc atggtggagg tgaagaacga
      661 cctgactgct aagaaaatgg tcacggcttt gatggagatg gcgcaccgcg accaccgtgc
      721 cctggactgc ttcgtggtgg tcatcctctc tcatggctgc caggccagcc acctccagtt
      781 cccgggtgct gtctatggca cagatggatg ctctgtgtcc atcgagagaa ttgtgaacat
      841 cttcaatggg accggctgcc ccagcctggg agggaagccc aagctgttct tcatccaggc
      901 ctgtggtggt gagcagaaag accatggctt tgaggtggcc ttcacttcct ctcaagacaa
      961 ggccttcgac agtgactctg agccagatgc tgtcccatac caggaaggcc caaggacctt
     1021 ggaccagctg gacgcagtgt caagtttgcc cacccccagt gacatccttg tgtcctactc
     1081 caccttccca ggttttgtct cctggagaga caagaagagc ggttcctggt acatcgagac
     1141 cttggatggt gtcctggagc agtgggctcg ctcggaagac ctgcagtccc tccttctcag
     1201 ggtcgccaat gctgtttctg agaaaggggt ttataagcag attcctggct gttttaactt
     1261 cctccggaag aagctgttct ttaaaacttc atgagtcagg ggctgctctc tgcctcattt
     1321 ttctcccaaa agccttcatg gcctggagta ggccaaggtc agaactgtcc cgtgaagcaa
     1381 ggatttcgaa ctggggcagg ctgctcttcc ccgtttccca tgcagacagg ctcctagcag
     1441 cttccaggtt ggaggagacg tgggacggtg ggaggggagg aacagagtac tgtggatgct
     1501 gcctggccgc ttcatctgtg gttagggact gtggcctggg acccccaggc ctctctagaa
     1561 cagggcttct ctgccgatgt accacggaca catgaggttg tgtaatcctg tcatgggact
     1621 gccccgtgtg ttgtagtgtt ttgagctgtc tctggtctcc acctgagcac ccctcctgag
     1681 ttctgccaac cagacatgtc ttcaggcatt gtcatgtgtg ccctggggga cattacagca
     1741 cccccctccc agggccatcg cccacagggg tctgtggctg cagacaccag catcactgct
     1801 tcccagaccc acagtccagc tggcccagtg tgaatacctg gatctggact gcgtctcatc
     1861 aaagtttcca gaagggttaa ttcttccttg agcacagtat ttatccttaa acaataaatc
     1921 ttaggcaaaa ggactgtctt ttgcctgtat catccccacc ctcactctgc tcttcctaca
     1981 atggagacta gctttttcct gagtatttct ctgtgttcca aggtctcggc ctgagcccag
     2041 gagttgactg aggtgggagc cagagtcccc actgatcaag tctcctgtct gttggttacc
     2101 ctagtgggga cacctggaca gtgtctccca gtgtcttcct tgctaagtga gcctggtcct
     2161 ccagtggcag tgaccgggca acagtgacat gttggcctcc cctgggaagg gtaccatccc
     2221 cgtctttaaa gctgttctga cttcattctg gtttcctctg gtctttgctg tgtgaacatt
     2281 cacttgaccg tagatggtaa gggtgccaag ccttgtttgt ttatttttga accatgctct
     2341 gactttgtag cccaggctag cctcaaagtc tccatcccac tgctcccgag tacagggatg
     2401 atagcttgtc actgccgcag gttgggccac aggtgttgct tccagggccc tggttagggt
     2461 gtcgggttaa taagacagac gcatcccatg gtgtgattcc taagtcactt tattactgtg
     2521 tcccttccgt gcgttcccaa ggtgacagtc acagagatgc ctttgcttag ttctttgcaa
     2581 tcacctgcag gacacacagg agagtgacgt taagctgagg gctgagcact gagttcagtg
     2641 acttctcagg gccaagaggt gcggtcgcag ttttcccctc ctgtcaagaa gggtcttggc
     2701 ccagagtcct gcttgggcgt caggcccgga agccgggaat cgattacaag ccaaatgtac
     2761 agatgggtgt ggttttttga tgtaatttgt ttctttgttt ttttttttct gagactgggt
     2821 ctccctgggt agccttggct gtcttggaac tcaccacata gacgagactg gccttgaact
     2881 cacagagatc cgcctgcctt tgcctctgag tactggtatt aaaagtgtgc acctcta
//
LOCUS       NM_001287579            2673 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein alpha (Cebpa),
            transcript variant 1, mRNA.
ACCESSION   NM_001287579
VERSION     NM_001287579.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Wu,K., Huang,S., Zheng,F. and Liu,Y.
  TITLE     The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway
  JOURNAL   Acta Diabetol 60 (11), 1491-1503 (2023)
   PUBMED   37392202
  REMARK    GeneRIF: The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Xu,Z., Yao,X., Zhao,Y. and Yao,B.
  TITLE     C/EBPalpha involvement in microglial polarization via HDAC1/STAT3
            pathway aggravated sevoflurane-induced cognitive impairment in aged
            rats
  JOURNAL   PeerJ 11, e15466 (2023)
   PUBMED   37361037
  REMARK    GeneRIF: C/EBPalpha involvement in microglial polarization via
            HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive
            impairment in aged rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Lu,H., Chen,Y., Chen,Y., Huang,L. and Chen,L.
  TITLE     C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates
            Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of
            Vascular Smooth Muscle Cells in Aortic Dissection
  JOURNAL   J Immunol Res 2022, 7465353 (2022)
   PUBMED   36132983
  REMARK    GeneRIF: C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A
            Regulates Autophagy, Matrix Metalloproteinase Expression, and
            Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Duan,P., Wang,H., Yi,X., Zhang,H., Chen,H. and Pan,Z.
  TITLE     C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells
            and steroid-induced avascular necrosis of the femoral head by
            targeting the PPARgamma signalling pathway
  JOURNAL   Stem Cell Res Ther 13 (1), 342 (2022)
   PUBMED   35883192
  REMARK    GeneRIF: C/EBPalpha regulates the fate of bone marrow mesenchymal
            stem cells and steroid-induced avascular necrosis of the femoral
            head by targeting the PPARgamma signalling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Muller,C., Bremer,A., Schreiber,S., Eichwald,S. and Calkhoven,C.F.
  TITLE     Nucleolar retention of a translational C/EBPalpha isoform
            stimulates rDNA transcription and cell size
  JOURNAL   EMBO J 29 (5), 897-909 (2010)
   PUBMED   20075868
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Samuelsson,L., Stromberg,K., Vikman,K., Bjursell,G. and Enerback,S.
  TITLE     The CCAAT/enhancer binding protein and its role in adipocyte
            differentiation: evidence for direct involvement in terminal
            adipocyte development
  JOURNAL   EMBO J 10 (12), 3787-3793 (1991)
   PUBMED   1935900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain and recognizes the
            CCAAT motif in the promoters of target genes. The encoded protein
            functions in homodimers and also heterodimers with
            CCAAT/enhancer-binding proteins beta and gamma. Activity of this
            protein can modulate the expression of genes involved in cell cycle
            regulation as well as in body weight homeostasis. The use of
            alternative in-frame non-AUG (CUG) and AUG start codons results in
            protein isoforms with different lengths. Differential translation
            initiation is mediated by an out-of-frame, upstream open reading
            frame which is located between the CUG and the first AUG start
            codons. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) can initiate translation from
            an upstream non-AUG (CUG) site, and also from three conserved
            downstream, in-frame AUG sites. The isoform (b) represented in this
            RefSeq results from translation initiation at the third AUG start
            codon. Isoform b has a shorter N-terminus, compared to isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.154041.1,
                                        SRR26643429.1696.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:10921906)
            regulatory uORF                  :: PMID: 10921906
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2673              JAXUCZ010000001.1  96896584-96899256
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="CCAAT/enhancer binding protein alpha"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
     exon            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    11..13
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative non-AUG (CUG) start codon;
                     isoform c"
     regulatory      97..114
                     /regulatory_class="uORF"
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10921906]"
                     /note="this uORF is predicted to encode a 5 aa peptide
                     (PMID:10921906)"
     misc_feature    122..124
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MESADFYEAEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEH
                     ETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGA
                     V"
     misc_feature    122..124
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform a"
     misc_feature    164..166
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAA
                     FNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAV"
     misc_feature    164..166
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform d"
     CDS             473..1198
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="isoform b is encoded by transcript variant 1; C/EBP
                     alpha; CAAT/enhancer-binding protein, DNA-binding protein;
                     CCAAT/enhancer binding protein (C/EBP), alpha"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein alpha isoform b"
                     /protein_id="NP_001274508.1"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
                     /translation="MSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQE
                     PREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPG
                     HPTPPPTPVPSPHPAPAMGAAGLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKKS
                     VDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSREL
                     DTLRGIFRQLPESSLVKAMGNCA"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
ORIGIN      
        1 cgacccaaag ctgcgcgggc gcgggcgagt tggggtactg ggtgggcggc ggcgacagcg
       61 gcgccacgcg caggctggag gccgccgagg ctcgccatgc cgggagaact ctaactcccc
      121 catggagtcg gccgacttct acgaggcgga gccgcggccc ccgatgagca gccacctcca
      181 gagccccccg cacgcgccca gcaacgccgc ctttggcttt ccccggggcg cgggccccgc
      241 gccgccccca gccccacctg ccgccccgga gccgctgggc ggcatctgcg agcacgagac
      301 gtctatagac atcagcgcct acatcgaccc ggccgccttc aacgacgagt tcctggccga
      361 cctcttccag cacagccggc agcaggagaa ggccaaggcg gcggcgggcc ccgcgggtgg
      421 cggcggtgac tttgactacc cgggcgcccc ggcgggcccc ggcggtgcgg tcatgtccgc
      481 gggggcgcac ggaccccctc ccggctacgg ctgtgcggcg gccggctacc tggacggcag
      541 gctggagccc ctgtacgagc gcgtcggggc gcccgcgctg cggccgctgg tgatcaagca
      601 ggagccccgc gaggaggacg aggcgaagca gctggcgctg gccggcctct tcccctatca
      661 gcccccgccg ccgccgccgc caccgcaccc gcacgcgtct cccgcgcact tggccgcccc
      721 tcacttgcag ttccagatcg cacactgcgg ccagaccacc atgcacctgc agcctggcca
      781 ccctacgccg ccgccgacgc ccgtgcccag ccctcatccc gcgcctgcaa tgggtgctgc
      841 gggcctgccg ggccccgggg gctcgctcaa gggcttggct ggtccgcacc ccgacctccg
      901 caccggcggc ggcggcggcg gcggggccgg cgcgggcaag gccaagaagt cggtggataa
      961 gaacagcaac gagtaccggg tacggcggga acgcaacaac atcgcggtgc gcaagagccg
     1021 agataaagcc aaacagcgca acgtggagac gcagcagaag gtgttggagt tgaccagtga
     1081 caatgaccgc ctgcgcaagc gggtggaaca gctgagccgt gaactggaca cgctgcgggg
     1141 tatcttccgc cagctgcctg agagctcctt ggtcaaggcc atgggcaact gcgcgtgagg
     1201 cgcgcggctg cgggaccgcc ttgagccggc cccctggctg gggacccgga ggatggttta
     1261 gggtcgctgg atctctaggc tgcccggacc gtgcaagcca ggactaggag attctggtgt
     1321 cgcctgaaag cctggcctgc tccgcgtgtc ccctcccttc ctctgagccg gactcggtgc
     1381 gtctaagatg agagggagtc aggccgtggt ggtttctcct ttagaccgag agacttctcc
     1441 gcggagctga gctgggagcc cggcagtttt agtattaagg aagtaacctt gtgccttgga
     1501 tactcaaaac tcgctccttt tcctaccgag tagggggagc aaacatgtgc cttgatattt
     1561 tatttggagg attcctgctt cctccagagc tgcagcaggc ccccatgaga aaaatgaagg
     1621 gtgcaggccc agggcaggag gaagattcag gaagctgagg tcccagcagt ccctgagctg
     1681 cccctccgtc cctgtcctta gaggggaggg acttagggag ttggggattt gagtcttaaa
     1741 agtgtcccca cccctagtta catggagatg gagggttctt agccccttgc ttttcgctcc
     1801 tccatctaca ttcctccccc cacccccagc ttacaacagg ccaggtttcc ttggtgagtt
     1861 cgtggagaag ggggcaacac ccccagtcag accagaaggc tgagttgtga actggccatg
     1921 tggttaagca agtggtagaa gacagggacc ttagtttctg gtcttggggt ggaggatgaa
     1981 gacactggga ccatccgcct tgtgtgtact gtatgtcgcc agccgctgtt gctgaaggaa
     2041 cttgaagcat aatcgatcca tcccagaggg actggagtta tgacaagctt cccaaatatt
     2101 ttgctttatc atctgatatc aacacttgta tctggtctct gtgtcccagc ggtgccttgt
     2161 gcaatgtcag tgtgcgcgtc tatgctaaac caccatttta tttggtcttt tgttttgttt
     2221 tggttttgct ctgattcttg ccaaaatgag actcttcacg aacggccagg ggaaggggct
     2281 gagtgaggct ctcattcttt ttggtttagg gatgtttggt ttttttgttt tgttttgttt
     2341 tgttttgttt tctttcgcct cccagaggac caatgaaatg aagtgggctt ctccctctcc
     2401 cctagttttc caagggtgta tgtagttgtg ggtcttagct tccttcctcc ggctgagact
     2461 tatactggct tccccaccca cccaccccca tccccaaagg ccctggctct gggtctggaa
     2521 agaaggccac ctccagccaa tttgtacaca accctgccac tggaagcagg ggtggactgc
     2581 ttccttctct tctttttttg gggggagggg acacaaagtt tcatgctaga tgtcctatgt
     2641 attatatcta taatataaac atatcaaact caa
//
LOCUS       NM_001287578            2673 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein alpha (Cebpa),
            transcript variant 1, mRNA.
ACCESSION   NM_001287578
VERSION     NM_001287578.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Wu,K., Huang,S., Zheng,F. and Liu,Y.
  TITLE     The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway
  JOURNAL   Acta Diabetol 60 (11), 1491-1503 (2023)
   PUBMED   37392202
  REMARK    GeneRIF: The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Xu,Z., Yao,X., Zhao,Y. and Yao,B.
  TITLE     C/EBPalpha involvement in microglial polarization via HDAC1/STAT3
            pathway aggravated sevoflurane-induced cognitive impairment in aged
            rats
  JOURNAL   PeerJ 11, e15466 (2023)
   PUBMED   37361037
  REMARK    GeneRIF: C/EBPalpha involvement in microglial polarization via
            HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive
            impairment in aged rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Lu,H., Chen,Y., Chen,Y., Huang,L. and Chen,L.
  TITLE     C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates
            Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of
            Vascular Smooth Muscle Cells in Aortic Dissection
  JOURNAL   J Immunol Res 2022, 7465353 (2022)
   PUBMED   36132983
  REMARK    GeneRIF: C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A
            Regulates Autophagy, Matrix Metalloproteinase Expression, and
            Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Duan,P., Wang,H., Yi,X., Zhang,H., Chen,H. and Pan,Z.
  TITLE     C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells
            and steroid-induced avascular necrosis of the femoral head by
            targeting the PPARgamma signalling pathway
  JOURNAL   Stem Cell Res Ther 13 (1), 342 (2022)
   PUBMED   35883192
  REMARK    GeneRIF: C/EBPalpha regulates the fate of bone marrow mesenchymal
            stem cells and steroid-induced avascular necrosis of the femoral
            head by targeting the PPARgamma signalling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Muller,C., Bremer,A., Schreiber,S., Eichwald,S. and Calkhoven,C.F.
  TITLE     Nucleolar retention of a translational C/EBPalpha isoform
            stimulates rDNA transcription and cell size
  JOURNAL   EMBO J 29 (5), 897-909 (2010)
   PUBMED   20075868
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Samuelsson,L., Stromberg,K., Vikman,K., Bjursell,G. and Enerback,S.
  TITLE     The CCAAT/enhancer binding protein and its role in adipocyte
            differentiation: evidence for direct involvement in terminal
            adipocyte development
  JOURNAL   EMBO J 10 (12), 3787-3793 (1991)
   PUBMED   1935900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain and recognizes the
            CCAAT motif in the promoters of target genes. The encoded protein
            functions in homodimers and also heterodimers with
            CCAAT/enhancer-binding proteins beta and gamma. Activity of this
            protein can modulate the expression of genes involved in cell cycle
            regulation as well as in body weight homeostasis. The use of
            alternative in-frame non-AUG (CUG) and AUG start codons results in
            protein isoforms with different lengths. Differential translation
            initiation is mediated by an out-of-frame, upstream open reading
            frame which is located between the CUG and the first AUG start
            codons. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) can initiate translation from
            an upstream non-AUG (CUG) site, and also from three conserved
            downstream, in-frame AUG sites. The isoform (d) represented in this
            RefSeq results from translation initiation at the second AUG start
            codon. Isoform d has a shorter N-terminus, compared to isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.154041.1,
                                        SRR26643429.1696.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:10921906)
            regulatory uORF                  :: PMID: 10921906
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2673              JAXUCZ010000001.1  96896584-96899256
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="CCAAT/enhancer binding protein alpha"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
     exon            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    11..13
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative non-AUG (CUG) start codon;
                     isoform c"
     regulatory      97..114
                     /regulatory_class="uORF"
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10921906]"
                     /note="this uORF is predicted to encode a 5 aa peptide
                     (PMID:10921906)"
     misc_feature    122..124
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MESADFYEAEPRPP"
     misc_feature    122..124
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform a"
     CDS             164..1198
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="isoform d is encoded by transcript variant 1; C/EBP
                     alpha; CAAT/enhancer-binding protein, DNA-binding protein;
                     CCAAT/enhancer binding protein (C/EBP), alpha"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein alpha isoform d"
                     /protein_id="NP_001274507.1"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
                     /translation="MSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEH
                     ETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGA
                     VMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALA
                     GLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPH
                     PAPAMGAAGLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKKSVDKNSNEYRVRRE
                     RNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPES
                     SLVKAMGNCA"
     misc_feature    473..475
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform b"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
ORIGIN      
        1 cgacccaaag ctgcgcgggc gcgggcgagt tggggtactg ggtgggcggc ggcgacagcg
       61 gcgccacgcg caggctggag gccgccgagg ctcgccatgc cgggagaact ctaactcccc
      121 catggagtcg gccgacttct acgaggcgga gccgcggccc ccgatgagca gccacctcca
      181 gagccccccg cacgcgccca gcaacgccgc ctttggcttt ccccggggcg cgggccccgc
      241 gccgccccca gccccacctg ccgccccgga gccgctgggc ggcatctgcg agcacgagac
      301 gtctatagac atcagcgcct acatcgaccc ggccgccttc aacgacgagt tcctggccga
      361 cctcttccag cacagccggc agcaggagaa ggccaaggcg gcggcgggcc ccgcgggtgg
      421 cggcggtgac tttgactacc cgggcgcccc ggcgggcccc ggcggtgcgg tcatgtccgc
      481 gggggcgcac ggaccccctc ccggctacgg ctgtgcggcg gccggctacc tggacggcag
      541 gctggagccc ctgtacgagc gcgtcggggc gcccgcgctg cggccgctgg tgatcaagca
      601 ggagccccgc gaggaggacg aggcgaagca gctggcgctg gccggcctct tcccctatca
      661 gcccccgccg ccgccgccgc caccgcaccc gcacgcgtct cccgcgcact tggccgcccc
      721 tcacttgcag ttccagatcg cacactgcgg ccagaccacc atgcacctgc agcctggcca
      781 ccctacgccg ccgccgacgc ccgtgcccag ccctcatccc gcgcctgcaa tgggtgctgc
      841 gggcctgccg ggccccgggg gctcgctcaa gggcttggct ggtccgcacc ccgacctccg
      901 caccggcggc ggcggcggcg gcggggccgg cgcgggcaag gccaagaagt cggtggataa
      961 gaacagcaac gagtaccggg tacggcggga acgcaacaac atcgcggtgc gcaagagccg
     1021 agataaagcc aaacagcgca acgtggagac gcagcagaag gtgttggagt tgaccagtga
     1081 caatgaccgc ctgcgcaagc gggtggaaca gctgagccgt gaactggaca cgctgcgggg
     1141 tatcttccgc cagctgcctg agagctcctt ggtcaaggcc atgggcaact gcgcgtgagg
     1201 cgcgcggctg cgggaccgcc ttgagccggc cccctggctg gggacccgga ggatggttta
     1261 gggtcgctgg atctctaggc tgcccggacc gtgcaagcca ggactaggag attctggtgt
     1321 cgcctgaaag cctggcctgc tccgcgtgtc ccctcccttc ctctgagccg gactcggtgc
     1381 gtctaagatg agagggagtc aggccgtggt ggtttctcct ttagaccgag agacttctcc
     1441 gcggagctga gctgggagcc cggcagtttt agtattaagg aagtaacctt gtgccttgga
     1501 tactcaaaac tcgctccttt tcctaccgag tagggggagc aaacatgtgc cttgatattt
     1561 tatttggagg attcctgctt cctccagagc tgcagcaggc ccccatgaga aaaatgaagg
     1621 gtgcaggccc agggcaggag gaagattcag gaagctgagg tcccagcagt ccctgagctg
     1681 cccctccgtc cctgtcctta gaggggaggg acttagggag ttggggattt gagtcttaaa
     1741 agtgtcccca cccctagtta catggagatg gagggttctt agccccttgc ttttcgctcc
     1801 tccatctaca ttcctccccc cacccccagc ttacaacagg ccaggtttcc ttggtgagtt
     1861 cgtggagaag ggggcaacac ccccagtcag accagaaggc tgagttgtga actggccatg
     1921 tggttaagca agtggtagaa gacagggacc ttagtttctg gtcttggggt ggaggatgaa
     1981 gacactggga ccatccgcct tgtgtgtact gtatgtcgcc agccgctgtt gctgaaggaa
     2041 cttgaagcat aatcgatcca tcccagaggg actggagtta tgacaagctt cccaaatatt
     2101 ttgctttatc atctgatatc aacacttgta tctggtctct gtgtcccagc ggtgccttgt
     2161 gcaatgtcag tgtgcgcgtc tatgctaaac caccatttta tttggtcttt tgttttgttt
     2221 tggttttgct ctgattcttg ccaaaatgag actcttcacg aacggccagg ggaaggggct
     2281 gagtgaggct ctcattcttt ttggtttagg gatgtttggt ttttttgttt tgttttgttt
     2341 tgttttgttt tctttcgcct cccagaggac caatgaaatg aagtgggctt ctccctctcc
     2401 cctagttttc caagggtgta tgtagttgtg ggtcttagct tccttcctcc ggctgagact
     2461 tatactggct tccccaccca cccaccccca tccccaaagg ccctggctct gggtctggaa
     2521 agaaggccac ctccagccaa tttgtacaca accctgccac tggaagcagg ggtggactgc
     2581 ttccttctct tctttttttg gggggagggg acacaaagtt tcatgctaga tgtcctatgt
     2641 attatatcta taatataaac atatcaaact caa
//
LOCUS       NM_012920               1510 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase II
            alpha (Camk2a), mRNA.
ACCESSION   NM_012920
VERSION     NM_012920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Dorovic,D., Lazarevic,V., Arandelovic,J., Stevanovic,V.,
            Paslawski,W., Zhang,X., Velimirovic,M., Petronijevic,N., Puskas,L.,
            Savic,M.M. and Svenningsson,P.
  TITLE     Maternal deprivation causes CaMKII downregulation and modulates
            glutamate, norepinephrine and serotonin in limbic brain areas in a
            rat model of single prolonged stress
  JOURNAL   J Affect Disord 349, 286-296 (2024)
   PUBMED   38199412
  REMARK    GeneRIF: Maternal deprivation causes CaMKII downregulation and
            modulates glutamate, norepinephrine and serotonin in limbic brain
            areas in a rat model of single prolonged stress.
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Yuan,G., Cao,C., Cao,D., Li,B., Li,X., Li,H., Shen,H., Wang,Z. and
            Chen,G.
  TITLE     Receptor-interacting protein 3-phosphorylated Ca2+
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis
  JOURNAL   J Neurochem 164 (1), 94-114 (2023)
   PUBMED   36424866
  REMARK    GeneRIF: Receptor-interacting protein 3-phosphorylated Ca[2+]
            /calmodulin-dependent protein kinase II and mixed lineage kinase
            domain-like protein mediate intracerebral hemorrhage-induced
            neuronal necroptosis.
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Radiske,A., Gonzalez,M.C., Rossato,J.I., Apolinario,G., de
            Oliveira,J.R., Bevilaqua,L.R.M. and Cammarota,M.
  TITLE     Avoidance memory requires CaMKII activity to persist after recall
  JOURNAL   Mol Brain 14 (1), 167 (2021)
   PUBMED   34775982
  REMARK    GeneRIF: Avoidance memory requires CaMKII activity to persist after
            recall.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Yong,X.L.H., Zhang,L., Yang,L., Chen,X., Tan,J.Z.A., Yu,X.,
            Chandra,M., Livingstone,E., Widagdo,J., Vieira,M.M., Roche,K.W.,
            Lynch,J.W., Keramidas,A., Collins,B.M. and Anggono,V.
  TITLE     Regulation of NMDA receptor trafficking and gating by
            activity-dependent CaMKIIalpha phosphorylation of the GluN2A
            subunit
  JOURNAL   Cell Rep 36 (1), 109338 (2021)
   PUBMED   34233182
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Cho,K.O., Hunt,C.A. and Kennedy,M.B.
  TITLE     The rat brain postsynaptic density fraction contains a homolog of
            the Drosophila discs-large tumor suppressor protein
  JOURNAL   Neuron 9 (5), 929-942 (1992)
   PUBMED   1419001
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Benfenati,F., Valtorta,F., Rubenstein,J.L., Gorelick,F.S.,
            Greengard,P. and Czernik,A.J.
  TITLE     Synaptic vesicle-associated Ca2+/calmodulin-dependent protein
            kinase II is a binding protein for synapsin I
  JOURNAL   Nature 359 (6394), 417-420 (1992)
   PUBMED   1328883
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Sunyer,T. and Sahyoun,N.
  TITLE     Sequence analysis and DNA-protein interactions within the 5'
            flanking region of the Ca2+/calmodulin-dependent protein kinase II
            alpha-subunit gene
  JOURNAL   Proc Natl Acad Sci U S A 87 (1), 278-282 (1990)
   PUBMED   2153289
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Thiel,G., Czernik,A.J., Gorelick,F., Nairn,A.C. and Greengard,P.
  TITLE     Ca2+/calmodulin-dependent protein kinase II: identification of
            threonine-286 as the autophosphorylation site in the alpha subunit
            associated with the generation of Ca2+-independent activity
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6337-6341 (1988)
   PUBMED   2842767
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Bulleit,R.F., Bennett,M.K., Molloy,S.S., Hurley,J.B. and
            Kennedy,M.B.
  TITLE     Conserved and variable regions in the subunits of brain type II
            Ca2+/calmodulin-dependent protein kinase
  JOURNAL   Neuron 1 (1), 63-72 (1988)
   PUBMED   2856087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1510
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="calcium/calmodulin-dependent protein kinase II
                     alpha"
                     /db_xref="GeneID:25400"
                     /db_xref="RGD:2261"
     exon            1..103
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    12..14
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="upstream in-frame stop codon"
     CDS             42..1478
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase type II
                     alpha chain; alpha CaM kinase II; caMK-II subunit alpha;
                     caM-kinase II alpha chain; caM kinase II subunit alpha;
                     calcium/calmodulin-dependent protein kinase (CaM kinase)
                     II alpha; Ca2+/calmodulin-dependent protein kinase II
                     alpha; calcium/calmodulin-dependent protein kinase II
                     alpha subunit"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit alpha"
                     /protein_id="NP_037052.1"
                     /db_xref="GeneID:25400"
                     /db_xref="RGD:2261"
                     /translation="MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKII
                     NTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIV
                     AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA
                     IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ
                     HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRST
                     VASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSEST
                     NTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGL
                     DFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSE
                     ETRVWHRRDGKWQIVHFHRSGAPSVLPH"
     misc_feature    72..947
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    72..947
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    78..80
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    order(96..110,120..122,159..161,165..167,258..260,
                     306..317,327..329,333..335,441..446,450..452,456..461,
                     465..467,504..509,516..518,561..575,579..581)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(96..110,120..122,159..161,165..167,258..260,
                     306..317,327..329,333..335,441..446,450..452,456..461,
                     465..467,504..509,516..518,561..575,579..581)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(96..107,120..122,159..161,165..167,258..260,
                     306..317,327..329,456..461,465..467,504..509)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(96..107,120..122,159..161,165..167,258..260,
                     306..317,327..329,456..461,465..467,504..509)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(108..110,327..329,333..335,441..446,450..452,
                     456..458,516..518,561..575,579..581)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(108..110,327..329,333..335,441..446,450..452,
                     456..458,516..518,561..575,579..581)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(504..536,543..575)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(504..536,543..575)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    810..812
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    897..899
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000269|PubMed:2842767; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    909..941
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="propagated from UniProtKB/Swiss-Prot (P11275.1);
                     Region: Calmodulin-binding"
     misc_feature    order(918..920,924..947)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(918..920,924..947)
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    969..1001
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="propagated from UniProtKB/Swiss-Prot (P11275.1);
                     Region: Interaction with BAALC.
                     /evidence=ECO:0000269|PubMed:15659234"
     misc_feature    981..1064
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="propagated from UniProtKB/Swiss-Prot (P11275.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1029..1031
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    1032..1034
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    1038..1040
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    1047..1049
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    1050..1052
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P11798; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     misc_feature    1077..1460
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1077..1460
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
     misc_feature    1251..1253
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P11275.1); phosphorylation site"
     exon            104..198
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            199..258
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            259..313
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            314..379
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            380..452
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            453..555
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            556..639
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            640..734
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            735..857
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            858..941
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            942..984
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1025
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1074
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1150
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1245
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1474
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1510
                     /gene="Camk2a"
                     /gene_synonym="PK2CDD; PKCCD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccgagc ctaaagcctc gcctgcctgc ccagtgccag gatggctacc atcacctgca
       61 cccgattcac ggaagagtac cagctcttcg aggaactggg aaagggagcc ttctccgtgg
      121 tgcgcaggtg tgtgaaggtg ctggctggcc aggagtatgc tgccaagatt atcaacacca
      181 agaagctctc agccagagat caccagaagt tggaacgcga ggcccgcatc tgccgcttgt
      241 tgaagcaccc caatatcgtc cgactccatg acagcatctc cgaggagggg caccactacc
      301 ttatcttcga tctggtcact ggtggggagc tgttcgaaga cattgtggcc cgggagtatt
      361 acagtgaggc tgatgccagc cactgtatcc agcagatcct ggaggctgtg ctacactgtc
      421 accagatggg ggtggtgcat cgcgacctga agcctgagaa tctgttgctg gcttcgaagc
      481 tcaagggtgc tgcggtgaag ctggcagact ttggcctggc catagaggtt gagggagagc
      541 agcaggcatg gtttgggttc gcagggacac ctggatacct ctccccagaa gtgctgcgga
      601 aggacccata cgggaagcct gtggacctgt gggcctgtgg cgtcatcctg tatatcttgc
      661 tggttgggta tcccccattc tgggatgagg accagcaccg cctgtaccag cagatcaaag
      721 ctggtgccta cgatttccca tcaccagaat gggacaccgt caccccggaa gccaaggatc
      781 tgatcaataa gatgctgacc atcaacccgt ccaaacgcat cacggccgct gaggctctca
      841 agcacccctg gatctcgcac cgctccactg tggcctcctg catgcacaga caggagaccg
      901 tggactgcct gaagaagttc aatgccagga ggaaactgaa gggagccatc ctcaccacta
      961 tgctggccac caggaacttc tccggaggga agagtggagg aaacaagaag aatgatggcg
     1021 tgaaggaatc ctctgagagc accaacacca ccatcgagga tgaagacacc aaagtgcgca
     1081 aacaggaaat tatcaaagtg acagagcagc tgatcgaagc cataagcaat ggagactttg
     1141 aatcctacac gaagatgtgc gaccctggaa tgacagcctt tgaaccggag gccctgggga
     1201 acctggtcga gggcctggac tttcatcgat tctattttga aaacctgtgg tcccggaaca
     1261 gcaagcccgt gcacaccacc atcctgaacc ctcacatcca cctgatgggt gacgagtcag
     1321 cctgcatcgc ctacatccgc atcactcagt acctggatgc gggtggcatc ccccgcacgg
     1381 cccagtcaga ggagacccgt gtctggcacc gcagggatgg aaaatggcag atcgtccact
     1441 tccacagatc tggggcgccc tccgtcctgc cccattgaag gaccaggcca gggtccctgc
     1501 gctcttgctt
//
LOCUS       NM_001191599            2742 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 9 (Prmt9),
            mRNA.
ACCESSION   NM_001191599 XM_214662
VERSION     NM_001191599.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Hadjikyriacou,A., Yang,Y., Espejo,A., Bedford,M.T. and Clarke,S.G.
  TITLE     Unique Features of Human Protein Arginine Methyltransferase 9
            (PRMT9) and Its Substrate RNA Splicing Factor SF3B2
  JOURNAL   J Biol Chem 290 (27), 16723-16743 (2015)
   PUBMED   25979344
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Yang,Y., Hadjikyriacou,A., Xia,Z., Gayatri,S., Kim,D.,
            Zurita-Lopez,C., Kelly,R., Guo,A., Li,W., Clarke,S.G. and
            Bedford,M.T.
  TITLE     PRMT9 is a type II methyltransferase that methylates the splicing
            factor SAP145
  JOURNAL   Nat Commun 6, 6428 (2015)
   PUBMED   25737013
  REMARK    Publication Status: Online-Only
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000019.1.
            
            On Jul 17, 2010 this sequence version replaced XM_214662.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.909746.1,
                                           SRR26360181.281363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000019.1  47318372-47318682   c
            312-460             JAXUCZ010000019.1  47311246-47311394   c
            461-697             JAXUCZ010000019.1  47308297-47308533   c
            698-865             JAXUCZ010000019.1  47307121-47307288   c
            866-968             JAXUCZ010000019.1  47304853-47304955   c
            969-1075            JAXUCZ010000019.1  47303367-47303473   c
            1076-1268           JAXUCZ010000019.1  47301941-47302133   c
            1269-1452           JAXUCZ010000019.1  47299123-47299306   c
            1453-2155           JAXUCZ010000019.1  47293900-47294602   c
            2156-2309           JAXUCZ010000019.1  47289673-47289826   c
            2310-2432           JAXUCZ010000019.1  47284926-47285048   c
            2433-2742           JAXUCZ010000019.1  47284351-47284660   c
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2742
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="protein arginine methyltransferase 9"
                     /db_xref="GeneID:291947"
                     /db_xref="RGD:1306157"
     exon            1..311
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    48..50
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="upstream in-frame stop codon"
     CDS             123..2648
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /EC_number="2.1.1.320"
                     /note="putative protein arginine N-methyltransferase 10;
                     putative protein arginine N-methyltransferase 9; protein
                     arginine methyltransferase 10 (putative)"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 9"
                     /protein_id="NP_001178528.1"
                     /db_xref="GeneID:291947"
                     /db_xref="RGD:1306157"
                     /translation="MPNSRPRSRRSAGGGAGTAGRDRLVAQSLQSAEHCLGDQDFGTA
                     YAHYLLVLSLAPELKEDVKETFQYTLFKWAEELHALNRIQDLLGCYEQALELFPDDEV
                     ICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDAKENFYRVANWLVERWHFIMLNDT
                     KRNEIYNAAIQKAVRLGSKTVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACD
                     VVAANKMEDGIRLLHMKSLDLEIPKHIPERVSLVVTETVDAGVFGEGIVESLIHAWEH
                     LLLQPQTKGESGSWGKYGKVIPASAVISGMAVECAEIRRHHRVSAKDIAGIHLPTNVR
                     FQSPAYASVDPEETVEPYTTEKMSGIPGGYRPLTECFQIMKVDFNNLQELKSLATRKP
                     HSLSVPAVKEGTLDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQALEDYWIQPG
                     DQVTMEASCHDCYLRIQGISILHLEHEMEVIKSFTKSKDLLSLGNEAELCSALANLQT
                     SRPEALEQTCVLEPTEIALLNNIPYHEGFRTAMRKVLSSLAPETPSQPMEAHCQDMET
                     NLESAPSTSDPFYVLDVSEGFSLLPILAGTLGQVQPYSSVEKDQHCIALDLISEANHF
                     PKETLEFWLRHIEDEAAVLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQ
                     SGGKIFPQYVLMFGMLVESQTLVEESAVQGTEHTLGLNIAPFINQFQVPIRVCLDLSS
                     LPCIPLSQPVELLRLDLMTPYLNTSNREVKVRVCRSGRLTAVPFWFHLCLDDEVRLDT
                     SGEASHWKQAAVVLDNPIQVQAGEELVLSVEHHKSNISITVKQ"
     misc_feature    <240..>542
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; Region: TPR; COG0457"
                     /db_xref="CDD:440225"
     misc_feature    <240..>542
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; Region: TPR; COG0457"
                     /db_xref="CDD:440225"
     misc_feature    order(324..326,333..338,345..350,354..356,426..428,
                     435..440,447..452,456..461,528..530,537..542)
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(324..326,333..338,345..350,354..356,426..428,
                     435..440,447..452,456..461,528..530,537..542)
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    324..407
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    324..407
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    420..512
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    420..512
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    564..>1091
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    564..>1091
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     exon            312..460
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            461..697
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            698..865
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            866..968
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1075
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1268
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1452
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2155
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2309
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2432
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2742
                     /gene="Prmt9"
                     /gene_synonym="Prmt10; RGD1306157"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgtgca ccgcactcct tttcgcgtcc tgttgctgcg acgggtctag ggaagcgagg
       61 tgtggagact ctttccggac gagggcgtcc tttttcgtgg gcttctgagc agagactcag
      121 ccatgccgaa ctcgaggccc aggtcccgcc ggagcgccgg gggtggcgca ggtacggccg
      181 gccgggaccg gctggtggca cagtccttgc agagcgctga gcactgtctg ggcgaccagg
      241 acttcgggac tgcctacgcc cattaccttc tggtgctcag cttggcgcca gaactcaaag
      301 aggacgtgaa ggaaactttc cagtatacac ttttcaagtg ggctgaagag cttcatgcac
      361 tgaatcgaat acaagactta cttggttgct acgagcaggc cttagagctg tttcctgatg
      421 atgaagtgat ttgcaacagt atgggagagc atctgttcag aatgggcttt cgagatgagg
      481 cagctgggta ttttcataaa gcagtgaagc taaaccctga tttcaacgat gcaaaggaga
      541 acttctatcg tgtggcaaac tggttggtag agcgctggca cttcatcatg cttaatgaca
      601 ccaagagaaa tgagatttat aacgcggcaa tccagaaggc agtgcggttg ggctccaaaa
      661 cagtgctgga cattggcgcc ggcactggga tactgagcat gtttgccaaa aaagctggtg
      721 cacactcagt atacgcctgt gagttatcca agaccatgta tgagctcgct tgtgacgtcg
      781 tggctgcaaa caagatggag gatgggatca ggctcctgca catgaagtca cttgatctag
      841 aaataccaaa gcacattcct gaaagagtgt ccctagttgt aacagaaact gtcgatgcag
      901 gtgtgtttgg agaaggaatt gtggagagtt taattcatgc atgggagcat ttacttctgc
      961 aaccacagac caaaggtgaa agtggaagtt gggggaagta tggaaaagtg ataccggcca
     1021 gtgcggtcat atctgggatg gcagtggagt gtgcagagat ccgaaggcat cacagggtta
     1081 gtgctaagga catagctggt atacatttac caacaaatgt gagatttcag agcccagcct
     1141 atgcgtctgt agatcccgaa gaaacggttg aaccatacac aacggaaaag atgagtggaa
     1201 tccctggagg ataccggcct ttgacagaat gctttcagat tatgaaagtt gatttcaata
     1261 atctccagga gttaaaaagt ctggcaacta ggaagccaca ctctcttagt gtacctgctg
     1321 ttaaggaagg cacgctggac gcgattatgg tctggtttgt tctccagctt gatgacgagc
     1381 acagtttgtc cacaagtccc agtgaggaga cctgttggga acaggctgtt tatccagtac
     1441 aggcacttga agactactgg atacagcctg gagaccaagt gacaatggag gcatcttgtc
     1501 acgattgtta cctaagaatc caggggatca gtatcttgca tttggaacat gaaatggaag
     1561 ttataaaaag ttttaccaag agtaaagact tgctctctct gggaaatgag gctgagctct
     1621 gtagtgccct ggctaacctt cagaccagta gaccagaagc tctggagcag acctgtgtgt
     1681 tagagcccac agagatcgct ttgcttaata acattccata tcatgaaggc ttcaggacag
     1741 caatgaggaa ggtattgtct tcactggccc cagagacgcc gagccagccc atggaagctc
     1801 actgtcagga catggagacg aacttggaga gtgcaccaag cacctctgac cctttctatg
     1861 tgttggatgt gtctgaaggc ttctctcttt tgcctatact tgctggaacc cttggtcagg
     1921 ttcagcccta cagttctgtg gagaaagacc agcactgtat tgctttggac ctcatatctg
     1981 aagccaatca cttccctaag gaaacacttg agttttggct gcgacacata gaagatgaag
     2041 ctgctgtgtt gcaaagaccc aaatcagaca agttatggag tataattata ctagatgtca
     2101 ttgagccgtc tgggctcatc cagcaggaga tcatggagaa ggccgcaata tccaggtgtt
     2161 tactgcagtc tggaggcaag attttcccgc agtacgtgct gatgtttgga atgctggtgg
     2221 agtcacagac gctggtagaa gagagtgctg ttcaaggaac agaacacact cttgggttaa
     2281 acatagcacc gtttattaac cagtttcagg tgcctatccg ggtctgtttg gatttatctt
     2341 ccttgccatg cattccttta agccagccag tggaactgtt gagattagat ctgatgactc
     2401 catatttgaa cacttccaat agagaagtga aggtccgtgt gtgcaggtct ggccgattga
     2461 ccgcggttcc attttggttt catttgtgcc tggatgacga ggtcaggttg gacacctcag
     2521 gtgaagcgtc ccattggaag caggctgcag tggtcctaga taatcccatc caagtacaag
     2581 caggagagga acttgtactt agtgttgagc atcacaaaag caacatcagc atcacagtga
     2641 agcagtgaga ccacggtcac acagcgaatg taagagaatc cttggaaccg tcaaccatgt
     2701 tgtacggtgg cattaataaa acccatggtc gaacttttaa aa
//
LOCUS       NM_031632               3036 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus caspase 9 (Casp9), transcript variant 1, mRNA.
ACCESSION   NM_031632
VERSION     NM_031632.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3036)
  AUTHORS   Bai,L., Yang,J., Zhang,H., Liao,W. and Cen,Y.
  TITLE     PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial
            ischemia/hypoxia-reperfusion injury via inactivation of apoptotic
            protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
  JOURNAL   Bioengineered 12 (1), 4385-4396 (2021)
   PUBMED   34304702
  REMARK    GeneRIF: PTB domain and leucine zipper motif 1 (APPL1) inhibits
            myocardial ischemia/hypoxia-reperfusion injury via inactivation of
            apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling
            pathway.
REFERENCE   2  (bases 1 to 3036)
  AUTHORS   Martin,S., Harrington,D.A., Ohlander,S., Stupp,S.I., McVary,K.T.
            and Podlasek,C.A.
  TITLE     Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog
            protein to the penis and cavernous nerve suppresses intrinsic and
            extrinsic apoptotic signaling mechanisms, which are an underlying
            cause of erectile dysfunction
  JOURNAL   Nanomedicine 37, 102444 (2021)
   PUBMED   34314869
  REMARK    GeneRIF: Peptide amphiphile nanofiber hydrogel delivery of Sonic
            hedgehog protein to the penis and cavernous nerve suppresses
            intrinsic and extrinsic apoptotic signaling mechanisms, which are
            an underlying cause of erectile dysfunction.
REFERENCE   3  (bases 1 to 3036)
  AUTHORS   Liu,H., Li,J., Jiang,C., Yuan,T. and Ma,H.
  TITLE     Cellular communication network factor 1 (CCN1) knockdown exerts a
            protective effect for hepatic ischemia/reperfusion injury by
            deactivating the MEK/ERK pathway
  JOURNAL   Clin Res Hepatol Gastroenterol 45 (5), 101737 (2021)
   PUBMED   34144219
REFERENCE   4  (bases 1 to 3036)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   5  (bases 1 to 3036)
  AUTHORS   Zhuang,C., Ni,S., Yang,Z.C. and Liu,R.P.
  TITLE     Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide
  JOURNAL   Oxid Med Cell Longev 2020, 3240820 (2020)
   PUBMED   33224431
  REMARK    GeneRIF: Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3036)
  AUTHORS   Vu,C.C., Bortner,C.D. and Cidlowski,J.A.
  TITLE     Differential involvement of initiator caspases in apoptotic volume
            decrease and potassium efflux during Fas- and UV-induced cell death
  JOURNAL   J Biol Chem 276 (40), 37602-37611 (2001)
   PUBMED   11431480
  REMARK    GeneRIF: The activation of caspase-8, but not caspase-9, is
            necessary for Fas-induced apoptosis. Conversely, caspase-9, but not
            caspase-8, is important for UV-mediated shrunken morphology and
            apoptosis progression.
REFERENCE   7  (bases 1 to 3036)
  AUTHORS   Angelastro,J.M., Moon,N.Y., Liu,D.X., Yang,A.S., Greene,L.A. and
            Franke,T.F.
  TITLE     Characterization of a novel isoform of caspase-9 that inhibits
            apoptosis
  JOURNAL   J Biol Chem 276 (15), 12190-12200 (2001)
   PUBMED   11278518
REFERENCE   8  (bases 1 to 3036)
  AUTHORS   Zaidi,A.U., D'Sa-Eipper,C., Brenner,J., Kuida,K., Zheng,T.S.,
            Flavell,R.A., Rakic,P. and Roth,K.A.
  TITLE     Bcl-X(L)-caspase-9 interactions in the developing nervous system:
            evidence for multiple death pathways
  JOURNAL   J Neurosci 21 (1), 169-175 (2001)
   PUBMED   11150333
REFERENCE   9  (bases 1 to 3036)
  AUTHORS   D'Sa-Eipper,C., Leonard,J.R., Putcha,G., Zheng,T.S., Flavell,R.A.,
            Rakic,P., Kuida,K. and Roth,K.A.
  TITLE     DNA damage-induced neural precursor cell apoptosis requires p53 and
            caspase 9 but neither Bax nor caspase 3
  JOURNAL   Development 128 (1), 137-146 (2001)
   PUBMED   11092819
REFERENCE   10 (bases 1 to 3036)
  AUTHORS   Kermer,P., Ankerhold,R., Klocker,N., Krajewski,S., Reed,J.C. and
            Bahr,M.
  TITLE     Caspase-9: involvement in secondary death of axotomized rat retinal
            ganglion cells in vivo
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 144-150 (2000)
   PUBMED   11146116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 30, 2024 this sequence version replaced NM_031632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286006.1, SRR26643290.21211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000005.1  159392086-159392245
            161-560             JAXUCZ010000005.1  159394338-159394737
            561-595             JAXUCZ010000005.1  159397278-159397312
            596-772             JAXUCZ010000005.1  159398840-159399016
            773-862             JAXUCZ010000005.1  159399389-159399478
            863-1010            JAXUCZ010000005.1  159400428-159400575
            1011-1190           JAXUCZ010000005.1  159406720-159406899
            1191-1300           JAXUCZ010000005.1  159407383-159407492
            1301-3036           JAXUCZ010000005.1  159408606-159410341
FEATURES             Location/Qualifiers
     source          1..3036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3036
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="caspase 9"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
     exon            1..160
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1393
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /EC_number="3.4.22.62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caspase-9-carboxyl-terminal divergent; 25 kDa caspase-9
                     dominant negative protein; caspase-9 dominant negative
                     form; apoptotic protease Mch-6; Ice-like apoptotic
                     protease 6; apoptotic protease activating factor 3;
                     caspase 9, apoptosis-related cysteine peptidase"
                     /codon_start=1
                     /product="caspase-9 isoform 1"
                     /protein_id="NP_113820.1"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
                     /translation="MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQ
                     RAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEA
                     VTPLDHLVPVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLT
                     PETPRPVDIGSGRAHDVCTPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTR
                     IGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHG
                     CQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGF
                     EVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSW
                     RDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEKGVYKQIPGCFNFLRKKLF
                     FKTS"
     misc_feature    83..298
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase activation and recruitment domain of
                     Caspase-9; Region: CARD_CASP9; cd08326"
                     /db_xref="CDD:176740"
     misc_feature    83..298
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase activation and recruitment domain of
                     Caspase-9; Region: CARD_CASP9; cd08326"
                     /db_xref="CDD:176740"
     misc_feature    596..1384
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    596..1384
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    order(680..682,854..856,995..997,1016..1018,1196..1213,
                     1223..1228)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(680..682,854..856,995..997,1016..1018,1196..1213,
                     1223..1228)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(851..853,1001..1003)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(851..853,1001..1003)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(1019..1021,1151..1156,1175..1177,1184..1186,
                     1193..1195,1262..1264,1286..1288,1304..1306,1334..1336,
                     1349..1354,1358..1360,1367..1372)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1019..1021,1151..1156,1175..1177,1184..1186,
                     1193..1195,1262..1264,1286..1288,1304..1306,1334..1336,
                     1349..1354,1358..1360,1367..1372)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1022..1024,1148..1150)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(1022..1024,1148..1150)
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     exon            161..560
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            561..595
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            596..772
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            773..862
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1010
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1190
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1300
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..3036
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccagggg tccagcaatc cgctagccat ggaggaggct gaccggcaac tcctgcggcg
       61 atgcagggta cgccttgtgc gcgaactgca agtcgcggag ctgtgggacg ctctgctgag
      121 tcgtgagctc ttcacgcgcg acatgatcga ggatattcag cgggcaggct ctgggtctcg
      181 gcgggatcag gccaggcagc tggtcataga tcttgagact cgagggaggc aggcccttcc
      241 tcgcttcatc tcctgcttag aggacacagg ccaaggctct ctggcttcat tcttgcaaag
      301 cagtgggcaa gcagccaagc aggatccaga agctgttaca cccctagacc acctggtgcc
      361 tgtggtcctg ggaccaatgg gactcaaatc aaaggagcag aaagtagtga agctggaccc
      421 atctcagcct gccttgggaa acctcacccc agtggtgctg gggccggaag agctctggcc
      481 tactcggctc aggccagagg ttctcacacc agaaacaccc aggccggtgg acattggttc
      541 tggcagagct catgatgtct gtactccagg gaagatcgag agacatgcag atatggcata
      601 caccctggac tcggatccct gtggccactg cctcatcatc aacaacgtga acttctgccc
      661 ttcctcaggg ctcagcacac gcattggctc ccacgtggac tgtgagaagc ttcagcaccg
      721 cttctgctgg ctgcgcttca tggtggaggt gaagaacgac ctgactgcta agaaaatggt
      781 cacggctttg atggagatgg cgcaccgcga ccaccgtgcc ctggactgct tcgtggtggt
      841 catcctctct catggctgcc aggccagcca cctccagttc ccgggtgctg tctatggcac
      901 agatggatgc tctgtgtcca tcgagagaat tgtgaacatc ttcaatggga ccggctgccc
      961 cagcctggga gggaagccca agctgttctt catccaggcc tgtggtggtg agcagaaaga
     1021 ccatggcttt gaggtggcct tcacttcctc tcaagacaag gccttcgaca gtgactctga
     1081 gccagatgct gtcccatacc aggaaggccc aaggaccttg gaccagctgg acgcagtgtc
     1141 aagtttgccc acccccagtg acatccttgt gtcctactcc accttcccag gttttgtctc
     1201 ctggagagac aagaagagcg gttcctggta catcgagacc ttggatggtg tcctggagca
     1261 gtgggctcgc tcggaagacc tgcagtccct ccttctcagg gtcgccaatg ctgtttctga
     1321 gaaaggggtt tataagcaga ttcctggctg ttttaacttc ctccggaaga agctgttctt
     1381 taaaacttca tgagtcaggg gctgctctct gcctcatttt tctcccaaaa gccttcatgg
     1441 cctggagtag gccaaggtca gaactgtccc gtgaagcaag gatttcgaac tggggcaggc
     1501 tgctcttccc cgtttcccat gcagacaggc tcctagcagc ttccaggttg gaggagacgt
     1561 gggacggtgg gaggggagga acagagtact gtggatgctg cctggccgct tcatctgtgg
     1621 ttagggactg tggcctggga cccccaggcc tctctagaac agggcttctc tgccgatgta
     1681 ccacggacac atgaggttgt gtaatcctgt catgggactg ccccgtgtgt tgtagtgttt
     1741 tgagctgtct ctggtctcca cctgagcacc cctcctgagt tctgccaacc agacatgtct
     1801 tcaggcattg tcatgtgtgc cctgggggac attacagcac ccccctccca gggccatcgc
     1861 ccacaggggt ctgtggctgc agacaccagc atcactgctt cccagaccca cagtccagct
     1921 ggcccagtgt gaatacctgg atctggactg cgtctcatca aagtttccag aagggttaat
     1981 tcttccttga gcacagtatt tatccttaaa caataaatct taggcaaaag gactgtcttt
     2041 tgcctgtatc atccccaccc tcactctgct cttcctacaa tggagactag ctttttcctg
     2101 agtatttctc tgtgttccaa ggtctcggcc tgagcccagg agttgactga ggtgggagcc
     2161 agagtcccca ctgatcaagt ctcctgtctg ttggttaccc tagtggggac acctggacag
     2221 tgtctcccag tgtcttcctt gctaagtgag cctggtcctc cagtggcagt gaccgggcaa
     2281 cagtgacatg ttggcctccc ctgggaaggg taccatcccc gtctttaaag ctgttctgac
     2341 ttcattctgg tttcctctgg tctttgctgt gtgaacattc acttgaccgt agatggtaag
     2401 ggtgccaagc cttgtttgtt tatttttgaa ccatgctctg actttgtagc ccaggctagc
     2461 ctcaaagtct ccatcccact gctcccgagt acagggatga tagcttgtca ctgccgcagg
     2521 ttgggccaca ggtgttgctt ccagggccct ggttagggtg tcgggttaat aagacagacg
     2581 catcccatgg tgtgattcct aagtcacttt attactgtgt cccttccgtg cgttcccaag
     2641 gtgacagtca cagagatgcc tttgcttagt tctttgcaat cacctgcagg acacacagga
     2701 gagtgacgtt aagctgaggg ctgagcactg agttcagtga cttctcaggg ccaagaggtg
     2761 cggtcgcagt tttcccctcc tgtcaagaag ggtcttggcc cagagtcctg cttgggcgtc
     2821 aggcccggaa gccgggaatc gattacaagc caaatgtaca gatgggtgtg gttttttgat
     2881 gtaatttgtt tctttgtttt tttttttctg agactgggtc tccctgggta gccttggctg
     2941 tcttggaact caccacatag acgagactgg ccttgaactc acagagatcc gcctgccttt
     3001 gcctctgagt actggtatta aaagtgtgca cctcta
//
LOCUS       NM_001108867            2553 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 5 (Prmt5),
            mRNA.
ACCESSION   NM_001108867 XM_001054376 XM_344405
VERSION     NM_001108867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Yeh,C.M., Lai,C.Y., Peng,H.Y., Lin,T.B., Chou,D., Wang,H.H.,
            Yang,P.S., Cheng,J.K., Peng,Y.C. and Hsieh,M.C.
  TITLE     Protein Arginine Methyltransferase 5 Contributes to
            Paclitaxel-Induced Neuropathic Pain by Activating Transient
            Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal
            Root Ganglion
  JOURNAL   Anesth Analg 138 (5), 1107-1119 (2024)
   PUBMED   37390022
  REMARK    GeneRIF: Protein Arginine Methyltransferase 5 Contributes to
            Paclitaxel-Induced Neuropathic Pain by Activating Transient
            Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal
            Root Ganglion.
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Cai,S., Wang,P., Xie,T., Li,Z., Li,J., Lan,R., Ding,Y., Lu,J.,
            Ye,J., Wang,J., Li,Z. and Liu,P.
  TITLE     Histone H4R3 symmetric di-methylation by Prmt5 protects against
            cardiac hypertrophy via regulation of Filip1L/beta-catenin
  JOURNAL   Pharmacol Res 161, 105104 (2020)
   PUBMED   32739429
  REMARK    GeneRIF: Histone H4R3 symmetric di-methylation by Prmt5 protects
            against cardiac hypertrophy via regulation of Filip1L/beta-catenin.
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Sun,M., Hussain,S., Hu,Y., Yan,J., Min,Z., Lan,X., Guo,Y., Zhao,Y.,
            Huang,H., Feng,M., Han,Y., Zhang,F., Zhu,W., Meng,L., Li,D., Sun,J.
            and Lu,S.
  TITLE     Maintenance of SOX9 stability and ECM homeostasis by
            selenium-sensitive PRMT5 in cartilage
  JOURNAL   Osteoarthritis Cartilage 27 (6), 932-944 (2019)
   PUBMED   30858101
  REMARK    GeneRIF: Maintenance of SOX9 stability and ECM homeostasis by
            selenium-sensitive PRMT5 in cartilage.
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Zhao,D.Y., Gish,G., Braunschweig,U., Li,Y., Ni,Z., Schmitges,F.W.,
            Zhong,G., Liu,K., Li,W., Moffat,J., Vedadi,M., Min,J., Pawson,T.J.,
            Blencowe,B.J. and Greenblatt,J.F.
  TITLE     SMN and symmetric arginine dimethylation of RNA polymerase II
            C-terminal domain control termination
  JOURNAL   Nature 529 (7584), 48-53 (2016)
   PUBMED   26700805
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Lim,Y., Kwon,Y.H., Won,N.H., Min,B.H., Park,I.S., Paik,W.K. and
            Kim,S.
  TITLE     Multimerization of expressed protein-arginine methyltransferases
            during the growth and differentiation of rat liver
  JOURNAL   Biochim Biophys Acta 1723 (1-3), 240-247 (2005)
   PUBMED   15837430
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Miranda,T.B., Khusial,P., Cook,J.R., Lee,J.H., Gunderson,S.I.,
            Pestka,S., Zieve,G.W. and Clarke,S.
  TITLE     Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically
            dimethylated at arginine residues in the nucleus
  JOURNAL   Biochem Biophys Res Commun 323 (2), 382-387 (2004)
   PUBMED   15369763
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Fabbrizio,E., El Messaoudi,S., Polanowska,J., Paul,C., Cook,J.R.,
            Lee,J.H., Negre,V., Rousset,M., Pestka,S., Le Cam,A. and Sardet,C.
  TITLE     Negative regulation of transcription by the type II arginine
            methyltransferase PRMT5
  JOURNAL   EMBO Rep 3 (7), 641-645 (2002)
   PUBMED   12101096
  REMARK    GeneRIF: These data provide the first direct experimental evidence
            that PRMT5, a type II arginine methylase, is involved in the
            control of transcription and proliferation.
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB814013.1, CO573950.1, DY553859.1, CB793692.1, CK845516.1,
            BQ210423.1, BE116721.1 and AI713913.1.
            
            On Apr 21, 2008 this sequence version replaced NM_001108867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               CB814013.1         12-355
            345-1012            CO573950.1         145-812
            1013-1413           DY553859.1         267-667
            1414-1614           CB793692.1         204-404
            1615-1774           CK845516.1         488-647             c
            1775-2261           BQ210423.1         1-487               c
            2262-2521           BE116721.1         18-277              c
            2522-2553           AI713913.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2553
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="protein arginine methyltransferase 5"
                     /db_xref="GeneID:364382"
                     /db_xref="RGD:1309053"
     exon            1..124
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1928
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /EC_number="2.1.1.125"
                     /note="SKB1 homolog; HMT1 hnRNP methyltransferase-like 5"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 5"
                     /protein_id="NP_001102337.2"
                     /db_xref="GeneID:364382"
                     /db_xref="RGD:1309053"
                     /translation="MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMP
                     VFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIHPDSKVEKIRRN
                     SEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAP
                     EDLRDDVIENAPTAHTEEYSGEEKTWLWWHNFRTLCDYSKRIAVALEIGADLPSSHVI
                     DRWLGEPIKAAILPTSIFLTNKKGFPVLSKMQQRLIFRLLKLEVQFIITGTNHHSEKE
                     FCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKY
                     SQYQQAIYKCLLDRVPEEEKETNVQVLMVLGAGRGPLVNASLRAAKQAERRIRLYAVE
                     KNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECL
                     DGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHN
                     FHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYRDITLS
                     IRPETHSPGMFSWFPIFFPIKQPITVHEGQNICVRFWRCSNSKKVWYEWAVTAPVCSS
                     IHNPTGRSYTIGL"
     misc_feature    123..884
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 TIM barrel domain; Region: PRMT5_TIM;
                     pfam17285"
                     /db_xref="CDD:435840"
     misc_feature    123..884
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 TIM barrel domain; Region: PRMT5_TIM;
                     pfam17285"
                     /db_xref="CDD:435840"
     misc_feature    897..1406
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 arginine-N-methyltransferase; Region: PRMT5;
                     pfam05185"
                     /db_xref="CDD:428356"
     misc_feature    897..1406
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 arginine-N-methyltransferase; Region: PRMT5;
                     pfam05185"
                     /db_xref="CDD:428356"
     misc_feature    1416..1919
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 oligomerization domain; Region: PRMT5_C;
                     pfam17286"
                     /db_xref="CDD:435841"
     misc_feature    1416..1919
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="PRMT5 oligomerization domain; Region: PRMT5_C;
                     pfam17286"
                     /db_xref="CDD:435841"
     exon            125..243
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..329
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..464
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..577
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..627
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..791
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..953
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1031
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1090
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1213
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1389
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1499
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1593
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1710
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1775
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..2536
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgaggga aaagatggcg gcgatggcag tcggaggtgc tggtggcagc cgcgtgtcca
       61 gcgggaggga cctgaattgc gtccctgaaa tagctgacac actgggtgct gtggccaagc
      121 aggggtttga tttcctctgc atgcctgtct tccacccgcg tttcaagagg gagttcattc
      181 aggaacctgc taagaatcgg cctggccccc agacacgatc agacctactg ctgtcaggaa
      241 gggactggaa tacgctaatt gtgggaaagc tttctccatg gattcatcca gactcaaaag
      301 tggagaagat ccgaaggaac tctgaggcgg ctatgttgca ggagctgaat tttggggcat
      361 atctaggtct tccagctttc ctattgcccc ttaatcagga agataacaca aatctggcca
      421 gagttctgac caaccacatc cacactggcc accattcttc catgttctgg atgagggtcc
      481 ccttggtggc cccagaggac ctgagagatg atgtaattga gaatgcacca actgcacaca
      541 cagaggagta cagtggagag gagaagacgt ggttgtggtg gcataacttc cggactctgt
      601 gtgactatag taagaggatt gcagtagctc ttgaaatcgg agctgacctc ccgtctagtc
      661 acgtcattga tcgttggctt ggagagccca tcaaagccgc cattctcccc accagcattt
      721 tcctaaccaa caagaagggg tttcctgttc tttctaagat gcagcagagg ctgatcttcc
      781 ggctcctcaa gttggaagtg caatttatca tcacgggaac caaccaccac tcagagaagg
      841 agttctgctc ctacctccag tacttggaat acttaagcca aaatcgtccc ccacccaatg
      901 cttacgaact ctttgccaaa ggctatgaag actatctgca gtccccactt cagcctctga
      961 tggacaatct ggaatctcag acgtacgaag tgttcgaaaa ggaccccatc aaatactctc
     1021 agtaccagca ggccatctat aaatgtttgc tagaccgagt accagaagaa gaaaaggaga
     1081 ccaatgtcca ggtacttatg gtgctgggtg caggccgagg tcctctagtg aatgcgtctc
     1141 tccgggcagc caagcaggct gagcggcgga ttaggctgta tgccgtggag aagaacccca
     1201 atgctgtggt gacgctagag aactggcagt ttgaagaatg ggggagtcag gtgacagttg
     1261 tctcgtcaga catgcgggaa tgggtggctc cggagaaggc agacatcatt gtcagtgaac
     1321 ttctgggctc ctttgccgac aatgagctgt cacctgagtg tctggatgga gcacagcact
     1381 tcctgaaaga tgatggtgta agcatccccg gagaatacac ctccttcctg gctcccattt
     1441 cttcctcgaa gttgtacaac gaggtccgcg cctgtcggga gaaggaccgt gaccctgagg
     1501 cacagtttga gatgccttat gtggttcggc tgcacaactt ccaccagctt tctgctcctc
     1561 agccctgttt taccttcagc catcccaacc gagatcctat gattgacaac aaccgctact
     1621 gtaccttgga gtttcctgtg gaggtgaaca cggtgcttca tggctttgca ggctactttg
     1681 aaactgtgct ttaccgggac atcactctga gtatccgccc agagacccac tctcctggca
     1741 tgttctcatg gttccccatc ttcttcccca tcaagcagcc catcacggtg catgaaggcc
     1801 agaacatctg tgtgcgtttc tggcgatgca gcaattctaa gaaggtgtgg tacgagtggg
     1861 cggtgacagc gccagtctgt tcttctattc acaaccctac tggtcgctcc tataccattg
     1921 gcctctagcc ctgcacacag cgtcagagcc ttggaagcag ctctgagttc tcttcctgta
     1981 gcacagaagg tgcagaacat ctactggttc agttcatctg tgagaccctc acctgccagc
     2041 gaggaacgat tcagtctgct tttctaccta tgtcatggtg gccagggggt aggcattcca
     2101 ggactgccaa gcatggtggt gcatactttt tatcccagca ctccagaggc agaggcaggt
     2161 gaatttcttt aagttcaagg ctagcctggt ctacccagca agtttcaggc cacctagggg
     2221 ctacatagtg agatcctgtc tccaaaaaag aaaaaaaaaa aaaaagaatt gcaggacaca
     2281 agccagcagc agttttcaga agcctctgtc gagggcacga ggactcagta gcactggagg
     2341 aagtggcatc ggcgggcgct caccctccag agcttcccag gggtcaggag aaaaggcaga
     2401 ggcttgtggg agagccccag gagtgtgcat gaacacttgc ggccttcccc tggccttact
     2461 ctgttgttgt ttggatgctt tgtgtcagaa ggaaacacaa ataaagagaa gttacggcct
     2521 ctgctgctct cccctgaaaa aaaaaaaaaa aaa
//
LOCUS       NM_001025144            2014 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 2 (Prmt2),
            mRNA.
ACCESSION   NM_001025144 XM_574738
VERSION     NM_001025144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Liu,S., Zhang,B., Guo,H., Ding,Z., Hou,W., Hu,X., Wang,Y., Tan,W.
            and Zhou,S.
  TITLE     The antidepressant effects of protein arginine methyltransferase 2
            involve neuroinflammation
  JOURNAL   Neurochem Int 176, 105728 (2024)
   PUBMED   38561150
  REMARK    GeneRIF: The antidepressant effects of protein arginine
            methyltransferase 2 involve neuroinflammation.
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Gayatri,S. and Bedford,M.T.
  TITLE     Readers of histone methylarginine marks
  JOURNAL   Biochim Biophys Acta 1839 (8), 702-710 (2014)
   PUBMED   24583552
  REMARK    Review article
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Di Lorenzo,A. and Bedford,M.T.
  TITLE     Histone arginine methylation
  JOURNAL   FEBS Lett 585 (13), 2024-2031 (2011)
   PUBMED   21074527
  REMARK    Review article
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   Iwasaki,H., Kovacic,J.C., Olive,M., Beers,J.K., Yoshimoto,T.,
            Crook,M.F., Tonelli,L.H. and Nabel,E.G.
  TITLE     Disruption of protein arginine N-methyltransferase 2 regulates
            leptin signaling and produces leanness in vivo through loss of
            STAT3 methylation
  JOURNAL   Circ Res 107 (8), 992-1001 (2010)
   PUBMED   20798359
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Yildirim,A.O., Bulau,P., Zakrzewicz,D., Kitowska,K.E.,
            Weissmann,N., Grimminger,F., Morty,R.E. and Eickelberg,O.
  TITLE     Increased protein arginine methylation in chronic hypoxia: role of
            protein arginine methyltransferases
  JOURNAL   Am J Respir Cell Mol Biol 35 (4), 436-443 (2006)
   PUBMED   16690984
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Yoshimoto,T., Boehm,M., Olive,M., Crook,M.F., San,H.,
            Langenickel,T. and Nabel,E.G.
  TITLE     The arginine methyltransferase PRMT2 binds RB and regulates E2F
            function
  JOURNAL   Exp Cell Res 312 (11), 2040-2053 (2006)
   PUBMED   16616919
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Ganesh,L., Yoshimoto,T., Moorthy,N.C., Akahata,W., Boehm,M.,
            Nabel,E.G. and Nabel,G.J.
  TITLE     Protein methyltransferase 2 inhibits NF-kappaB function and
            promotes apoptosis
  JOURNAL   Mol Cell Biol 26 (10), 3864-3874 (2006)
   PUBMED   16648481
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Qi,C., Chang,J., Zhu,Y., Yeldandi,A.V., Rao,S.M. and Zhu,Y.J.
  TITLE     Identification of protein arginine methyltransferase 2 as a
            coactivator for estrogen receptor alpha
  JOURNAL   J Biol Chem 277 (32), 28624-28630 (2002)
   PUBMED   12039952
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Kzhyshkowska,J., Schutt,H., Liss,M., Kremmer,E., Stauber,R.,
            Wolf,H. and Dobner,T.
  TITLE     Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in
            its Arg-Gly-Gly (RGG) box and interacts with human arginine
            methyltransferase HRMT1L1
  JOURNAL   Biochem J 358 (Pt 2), 305-314 (2001)
   PUBMED   11513728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079112.1.
            
            On Jul 1, 2005 this sequence version replaced XM_574738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079112.1, SRR8487231.110690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2014
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="protein arginine methyltransferase 2"
                     /db_xref="GeneID:499420"
                     /db_xref="RGD:1565519"
     exon            1..49
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..158
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    99..101
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="upstream in-frame stop codon"
     CDS             105..1442
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /EC_number="2.1.1.125"
                     /note="HMT1 hnRNP methyltransferase-like 1"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 2"
                     /protein_id="NP_001020315.1"
                     /db_xref="GeneID:499420"
                     /db_xref="RGD:1565519"
                     /translation="MEAPAEDPSHESQVTPAPEEDPVDYGCEMQLLQDGAQLQLQLQP
                     EEFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHLGKQVEE
                     YDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGT
                     GIISLFCAHHARPKAVYAVEASDMAQHTGQLVLQNGFADTITVFQQKVEDVVLPEKVD
                     VLVSEWMGTCLLFEFMIESILYARDAWLKEDGIIWPTTAALHLVPCSAEKDYHSKVLF
                     WDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVSDLETM
                     RGELRFDIQKAGTLHGFTAWFSVHFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDP
                     VPVHTGDVVTGSVVLQRNPVWRRHMSVCLSWVVTSAVDPTSQRAGEKVFPIWR"
     misc_feature    240..398
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="Src homology 3 domain of Protein arginine
                     N-methyltransferase 2; Region: SH3_PRMT2; cd11806"
                     /db_xref="CDD:212740"
     misc_feature    240..398
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="Src homology 3 domain of Protein arginine
                     N-methyltransferase 2; Region: SH3_PRMT2; cd11806"
                     /db_xref="CDD:212740"
     misc_feature    order(255..257,261..263,270..272,282..284,336..341,
                     378..380,384..389)
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212740"
     misc_feature    order(255..257,261..263,270..272,282..284,336..341,
                     378..380,384..389)
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212740"
     misc_feature    474..>911
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    474..>911
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     exon            159..284
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..467
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..629
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..794
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..970
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1100
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1237
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1409
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1981
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgttccttt ctgggctagc ctagaattca gcggagaaac gcggctgaga cgtgatgaga
       61 agatgaagtg aggcaccagt tatgagacat gagcttactg aactatggag gcaccagctg
      121 aagatcccag ccatgagtca caggtcaccc cagctccgga ggaagaccct gtggactatg
      181 gctgtgagat gcagctcctt caggacgggg cacagttgca gctgcagctg cagcccgagg
      241 agttcgtagc cattgcagat tacaccgcca ccgacgagac acagctcagc tttctgagag
      301 gagaaaaaat tctgatcctg aggcaaacca cggcggactg gtggtggggc gaacgtgcgg
      361 gctgctgcgg gtacatcccc gcaaaccacc ttgggaagca ggtggaggag tacgacccgg
      421 aggacacctg gcaagatgag gagtacttcg acagctatgg gactctgaaa cttcacctgg
      481 aaatgttggc tgaccagcct cggacaacca agtaccacag tgtcatcctg cagaacaagg
      541 agtctctgaa ggacaaggtc atactggatg tgggctgcgg caccggcatc atcagccttt
      601 tctgcgctca tcatgcccgg cccaaggcag tgtacgcggt agaagccagt gacatggccc
      661 agcacacggg ccagctggtc ctgcagaatg gctttgctga cacaatcact gtgtttcagc
      721 agaaggtgga ggacgtggtg ttgcccgaga aggtggacgt gctggtgtcg gagtggatgg
      781 ggacctgtct cttgtttgag ttcatgatcg agtccatcct gtacgcccgg gatgcctggt
      841 taaaggaaga tggcatcatt tggccaacca cggcggcact gcacttggta ccctgcagcg
      901 ctgagaaaga ctaccacagc aaggtgctct tctgggacaa cgcgtacgag ttcaacctca
      961 gtgcactcaa gtcgttagca atcaaggagt tcttttcaag gccaaagtct aatcatatct
     1021 tgaagccaga agactgcctc tctgagccat gcacaatatt gcagttggac atgagaactg
     1081 tgcaggtctc tgacctggag accatgcgtg gcgagctgcg atttgacatc caaaaggctg
     1141 ggaccctgca tggcttcaca gcttggttca gtgtacattt ccagagcctg gaggagggcc
     1201 agcctcagca ggttctcagc acaggaccgc tgcaccccac cacacactgg aagcagacct
     1261 tgtttatgat ggacgaccca gtcccagtcc acacaggaga cgtggtcacg ggttcggtgg
     1321 tgttacagag aaatccggtg tggagaaggc acatgtccgt ctgtctgagc tgggtcgtca
     1381 cttccgcagt tgatcccacg tctcaaaggg ctggagagaa agtctttccg atctggaggt
     1441 gacggttaag caccgcgtgg gagtcacggc cgtggtgtgc atcttggtgg aagaagatgc
     1501 gtctggccac cttctgtgac gtacacactc acccgtccca tgctgacccc ttcccaccca
     1561 gcaggtgaca tcgggcccct cacagctcac cccccaaccc ccagtgtcat ttctcccgta
     1621 ggctgtgtat atatataggt gttcatcctg tggtgcccgt cgctgccagc cgtgttccca
     1681 gccgggagta gttgtagatc cctcagacac acatttcagc ctgtgtacct gtgactgtga
     1741 tgtccacacc ttgtgtcagt ggtgtccttg atgccctcga ccagctgctg cacctgtgga
     1801 ctgtggcttg ccgagccgtg ctccggtatg agagatggcc gagcacccgt gtctcggggc
     1861 aaggactgga ggtggcagcg tgcgcagtgg gctctgcatg ggtagccgcg tgtaacgtct
     1921 tatgggtaaa ttatatgtgg ggcatagtac atgctcaata aatatttttt aatgaacaaa
     1981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
LOCUS       NM_013068                564 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus fatty acid binding protein 2 (Fabp2), mRNA.
ACCESSION   NM_013068
VERSION     NM_013068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 564)
  AUTHORS   Zenger,S., Demir Piroglu,I., Cevik,A., Ozcabi,Y., Fakioglu,D.,
            Senol,M., Altintas,M.M., Bildik,N. and Yucel,T.
  TITLE     The importance of serum intestinal fatty acid-binding protein for
            the early diagnosis of acute mesenteric ischemia
  JOURNAL   Ulus Travma Acil Cerrahi Derg 27 (3), 278-283 (2021)
   PUBMED   33884597
  REMARK    GeneRIF: The importance of serum intestinal fatty acid-binding
            protein for the early diagnosis of acute mesenteric ischemia.',
            trans 'Akut mezenter iskeminin erken tanisinda serum intestinal yag
            asidi baglayici proteininin onemi.
REFERENCE   2  (bases 1 to 564)
  AUTHORS   Sahin,A., Altay,D.A., Demir,S., Yulug,E., Mentese,A., Tatli,O.,
            Karaca,Y., Ardic,S., Gunduz,A. and Turedi,S.
  TITLE     Comparison of the diagnostic values of vascular adhesion protein-1
            and intestinal fatty acid-binding protein in the diagnosis of acute
            mesenteric ischemia
  JOURNAL   Eur J Trauma Emerg Surg 45 (3), 545-553 (2019)
   PUBMED   29600311
  REMARK    GeneRIF: In acute mesenteric ischemia, Fabp2 levels are
            significantly increased and correlated with ischemic changes.
REFERENCE   3  (bases 1 to 564)
  AUTHORS   Popescu,G.A., Jung,I., Cordos,B.A., Azamfirei,L., Hutanu,A. and
            Gurzu,S.
  TITLE     Intestinal fatty acid-binding protein, as a marker of anastomotic
            leakage after colonic resection in rats
  JOURNAL   Rom J Morphol Embryol 59 (4), 1075-1081 (2018)
   PUBMED   30845287
  REMARK    GeneRIF: The aim of this experimental study was to determine if the
            type of termino-terminal anastomosis of the colon affect the
            process of healing of the intestinal mucosa and if the severity of
            the anastomotic leakage (AL) can be predicted based on the
            circulating level of intestinal fatty acid-binding protein.
REFERENCE   4  (bases 1 to 564)
  AUTHORS   Mandave,P., Khadke,S., Karandikar,M., Pandit,V., Ranjekar,P.,
            Kuvalekar,A. and Mantri,N.
  TITLE     Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of
            the Strawberry: A Potent Supplementary Fruit
  JOURNAL   Int J Mol Sci 18 (1), 124 (2017)
   PUBMED   28085064
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 564)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 564)
  AUTHORS   Scapin,G., Gordon,J.I. and Sacchettini,J.C.
  TITLE     Refinement of the structure of recombinant rat intestinal fatty
            acid-binding apoprotein at 1.2-A resolution
  JOURNAL   J Biol Chem 267 (6), 4253-4269 (1992)
   PUBMED   1740465
REFERENCE   7  (bases 1 to 564)
  AUTHORS   Green,R.P., Cohn,S.M., Sacchettini,J.C., Jackson,K.E. and
            Gordon,J.I.
  TITLE     The mouse intestinal fatty acid binding protein gene: nucleotide
            sequence, pattern of developmental and regional expression, and
            proposed structure of its protein product
  JOURNAL   DNA Cell Biol 11 (1), 31-41 (1992)
   PUBMED   1739433
REFERENCE   8  (bases 1 to 564)
  AUTHORS   Sacchettini,J.C., Gordon,J.I. and Banaszak,L.J.
  TITLE     Refined apoprotein structure of rat intestinal fatty acid binding
            protein produced in Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7736-7740 (1989)
   PUBMED   2682622
REFERENCE   9  (bases 1 to 564)
  AUTHORS   Sacchettini,J.C., Gordon,J.I. and Banaszak,L.J.
  TITLE     Crystal structure of rat intestinal fatty-acid-binding protein.
            Refinement and analysis of the Escherichia coli-derived protein
            with bound palmitate
  JOURNAL   J Mol Biol 208 (2), 327-339 (1989)
   PUBMED   2671390
REFERENCE   10 (bases 1 to 564)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M35992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: K01180.1, M35992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..564
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="fatty acid binding protein 2"
                     /db_xref="GeneID:25598"
                     /db_xref="RGD:2591"
     exon            1..79
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..411
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="FABPI; I-FABP; intestinal-type fatty acid-binding
                     protein; intestinal fatty acid binding protein; fatty acid
                     binding protein 1; fatty acid binding protein 2,
                     intestinal"
                     /codon_start=1
                     /product="fatty acid-binding protein, intestinal"
                     /protein_id="NP_037200.1"
                     /db_xref="GeneID:25598"
                     /db_xref="RGD:2591"
                     /translation="MAFDGTWKVDRNENYEKFMEKMGINVVKRKLGAHDNLKLTITQE
                     GNKFTVKESSNFRNIDVVFELGVDFAYSLADGTELTGTWTMEGNKLVGKFKRVDNGKE
                     LIAVREISGNELIQTYTYEGVEAKRIFKKE"
     misc_feature    16..405
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="fatty acid-binding protein 2; Region: FABP2;
                     cd19445"
                     /db_xref="CDD:381220"
     misc_feature    16..405
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="fatty acid-binding protein 2; Region: FABP2;
                     cd19445"
                     /db_xref="CDD:381220"
     misc_feature    16..18
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000269|PubMed:6582489; propagated from
                     UniProtKB/Swiss-Prot (P02693.4); acetylation site"
     misc_feature    order(19..21,55..57,64..69,76..78,82..84,94..99,106..108,
                     121..123,127..129,133..135,154..156,160..162,166..168,
                     187..189,193..195,199..201,223..225,229..231,259..261,
                     280..282,286..288,325..327,331..333,352..354,358..360,
                     364..366,391..393,397..399)
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="ligand binding cavity [chemical binding]; other
                     site"
                     /db_xref="CDD:381220"
     misc_feature    order(19..21,55..57,64..69,76..78,82..84,94..99,106..108,
                     121..123,127..129,133..135,154..156,160..162,166..168,
                     187..189,193..195,199..201,223..225,229..231,259..261,
                     280..282,286..288,325..327,331..333,352..354,358..360,
                     364..366,391..393,397..399)
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="ligand binding cavity [chemical binding]; other
                     site"
                     /db_xref="CDD:381220"
     exon            80..252
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            253..360
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            361..564
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctgaca tcatggcatt tgatggcact tggaaagtag accggaatga gaactatgaa
       61 aagttcatgg agaaaatggg cattaacgtg gtgaagagga agcttggagc tcatgacaac
      121 ttgaaactga cgatcacaca ggaaggaaat aaattcacag tcaaagaatc aagcaacttc
      181 cgaaacattg atgttgtgtt tgaactcggc gtcgactttg cctatagtct agcagatgga
      241 acagaactca ctgggacctg gaccatggag ggaaataaac ttgttggaaa attcaaacgt
      301 gtagacaatg gaaaggagct gattgctgtc cgagagattt ctggtaacga actaatccaa
      361 acctacacat atgaaggagt ggaggccaag cggatcttta agaaggaata ggccagcttc
      421 ttggagcctg gcgcaatgca gaagggctag cttggtgtcg gattcctttc tccatctcgc
      481 tgataatgca ggctcactca ctgtgtcatg agcactgctt ccaagccttg tcagagccaa
      541 agaagtaaaa gttgattagg actt
//
LOCUS       NM_019165               1197 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus interleukin 18 (Il18), mRNA.
ACCESSION   NM_019165 XM_001070641
VERSION     NM_019165.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Borgonetti,V., Cruz,B., Vozella,V., Khom,S., Steinman,M.Q.,
            Bullard,R., D'Ambrosio,S., Oleata,C.S., Vlkolinsky,R., Bajo,M.,
            Zorrilla,E.P., Kirson,D. and Roberto,M.
  TITLE     IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a
            Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
  JOURNAL   Cells 12 (15), 1943 (2023)
   PUBMED   37566022
  REMARK    GeneRIF: IL-18 Signaling in the Rat Central Amygdala Is Disrupted
            in a Comorbid Model of Post-Traumatic Stress and Alcohol Use
            Disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Tavarna,T., Wolfe,B., Wu,X.J. and Reyes,L.
  TITLE     Porphyromonas gingivalis-mediated disruption in spiral artery
            remodeling is associated with altered uterine NK cell populations
            and dysregulated IL-18 and Htra1
  JOURNAL   Sci Rep 12 (1), 14799 (2022)
   PUBMED   36042379
  REMARK    GeneRIF: Porphyromonas gingivalis-mediated disruption in spiral
            artery remodeling is associated with altered uterine NK cell
            populations and dysregulated IL-18 and Htra1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Abu-Risha,S.E., Mousa,M.A. and Elsisi,A.E.
  TITLE     Protective role of irbesartan against cyclophosphamide-induced
            testicular damage in rats via up-regulating PPAR-gamma signaling
            and ameliorating NF-kappaB/NLRP3/IL-18 inflammatory axis
  JOURNAL   Life Sci 289, 120218 (2022)
   PUBMED   34890588
  REMARK    GeneRIF: Protective role of irbesartan against
            cyclophosphamide-induced testicular damage in rats via
            up-regulating PPAR-gamma signaling and ameliorating
            NF-kappaB/NLRP3/IL-18 inflammatory axis.
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Simanullang,R.H., Situmorang,P.C., Ginting,L., Tarigan,E.R.,
            Syahputra,R.A., Chairunisa,C. and Maliki,M.F.
  TITLE     PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa
  JOURNAL   Pak J Biol Sci 25 (11), 986-992 (2022)
   PUBMED   36591929
  REMARK    GeneRIF: PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa.
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Wang,Y.F., Wang,Y., Zhang,Y., Guo,X., He,X., Zhang,J.L. and
            Rong,P.J.
  TITLE     [Effect of transcutaneous auricular vagus nerve stimulation on the
            expression of TLR4MyD88IL-18 protein in the prefrontal cortex of
            depression rats]
  JOURNAL   Zhen Ci Yan Jiu 46 (7), 580-585 (2021)
   PUBMED   34369678
  REMARK    GeneRIF: [Effect of transcutaneous auricular vagus nerve
            stimulation on the expression of TLR4MyD88IL-18 protein in the
            prefrontal cortex of depression rats].
REFERENCE   6  (bases 1 to 1197)
  AUTHORS   Wildbaum,G., Youssef,S., Grabie,N. and Karin,N.
  TITLE     Neutralizing antibodies to IFN-gamma-inducing factor prevent
            experimental autoimmune encephalomyelitis
  JOURNAL   J Immunol 161 (11), 6368-6374 (1998)
   PUBMED   9834127
REFERENCE   7  (bases 1 to 1197)
  AUTHORS   Xu,B., Aoyama,K., Yu,S., Kitani,A., Okamura,H., Kurimoto,M.,
            Matsuyama,T. and Matsushita,T.
  TITLE     Expression of interleukin-18 in murine contact hypersensitivity
  JOURNAL   J Interferon Cytokine Res 18 (9), 653-659 (1998)
   PUBMED   9781803
REFERENCE   8  (bases 1 to 1197)
  AUTHORS   Culhane,A.C., Hall,M.D., Rothwell,N.J. and Luheshi,G.N.
  TITLE     Cloning of rat brain interleukin-18 cDNA
  JOURNAL   Mol Psychiatry 3 (4), 362-366 (1998)
   PUBMED   9702748
REFERENCE   9  (bases 1 to 1197)
  AUTHORS   Conti,B., Jahng,J.W., Tinti,C., Son,J.H. and Joh,T.H.
  TITLE     Induction of interferon-gamma inducing factor in the adrenal cortex
  JOURNAL   J Biol Chem 272 (4), 2035-2037 (1997)
   PUBMED   8999896
REFERENCE   10 (bases 1 to 1197)
  AUTHORS   Micallef,M.J., Ohtsuki,T., Kohno,K., Tanabe,F., Ushio,S., Namba,M.,
            Tanimoto,T., Torigoe,K., Fujii,M., Ikeda,M., Fukuda,S. and
            Kurimoto,M.
  TITLE     Interferon-gamma-inducing factor enhances T helper 1 cytokine
            production by stimulated human T cells: synergism with
            interleukin-12 for interferon-gamma production
  JOURNAL   Eur J Immunol 26 (7), 1647-1651 (1996)
   PUBMED   8766574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 20, 2020 this sequence version replaced NM_019165.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY077842.1, CF109780.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760494, SAMN17050747 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000008.1  59802072-59802185
            115-156             JAXUCZ010000008.1  59802403-59802444
            157-321             JAXUCZ010000008.1  59803327-59803491
            322-482             JAXUCZ010000008.1  59813421-59813581
            483-566             JAXUCZ010000008.1  59822654-59822737
            567-578             JAXUCZ010000008.1  59823916-59823927
            579-713             JAXUCZ010000008.1  59825273-59825407
            714-847             JAXUCZ010000008.1  59826634-59826767
            848-1197            JAXUCZ010000008.1  59828926-59829275
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1197
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="interleukin 18"
                     /db_xref="GeneID:29197"
                     /db_xref="RGD:2889"
     exon            1..114
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            115..156
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            157..321
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            322..482
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    377..379
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="upstream in-frame stop codon"
     exon            483..566
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..1072
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="interleukin-1 gamma; IFN-gamma-inducing factor;
                     interferon gamma-inducing factor"
                     /codon_start=1
                     /product="interleukin-18"
                     /protein_id="NP_062038.2"
                     /db_xref="GeneID:29197"
                     /db_xref="RGD:2889"
                     /translation="MAAIPEEGSCVNFKEMMFIDNTLYLIPEDNGDLESDHFGRLHCT
                     TAVMRSINDQVLFVDKRNPPVFEDMPDIDRTANESQTRLIIYMYKDSEVRGLAVTLSV
                     KDGRMSTLSCKNKIISFEEMNPPENIDDIKSDLIFFQKRVPGHNKMEFESSLYEGHFL
                     ACQKEDDAFKLVLKRKDENGDKSVMFTLTNLHQS"
     misc_feature    593..598
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="Cleavage, by CASP1.
                     /evidence=ECO:0000250|UniProtKB:Q14116; propagated from
                     UniProtKB/Swiss-Prot (P97636.1); cleavage site"
     mat_peptide     596..1069
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /product="Interleukin-18. /id=PRO_0000015350"
                     /note="propagated from UniProtKB/Swiss-Prot (P97636.1)"
     misc_feature    611..1051
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="beta-trefoil domain found in interleukin-18 (IL-18)
                     and similar proteins; Region: beta-trefoil_IL18; cd23298"
                     /db_xref="CDD:466780"
     misc_feature    611..1051
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="beta-trefoil domain found in interleukin-18 (IL-18)
                     and similar proteins; Region: beta-trefoil_IL18; cd23298"
                     /db_xref="CDD:466780"
     misc_feature    order(617..619,746..757,767..778,866..868,902..910,
                     920..925,929..931)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="antagonist binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:466780"
     misc_feature    order(617..619,746..757,767..778,866..868,902..910,
                     920..925,929..931)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="antagonist binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:466780"
     misc_feature    order(644..646,656..658,680..682,686..703,752..760,
                     770..775,902..910,920..922,929..931,986..991)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="receptor interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:466780"
     misc_feature    order(644..646,656..658,680..682,686..703,752..760,
                     770..775,902..910,920..922,929..931,986..991)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="receptor interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:466780"
     misc_feature    698..703
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q14116; propagated from
                     UniProtKB/Swiss-Prot (P97636.1); cleavage site"
     misc_feature    order(905..907,917..919,926..928,938..940,953..955,
                     962..964,1010..1018,1022..1033,1040..1042)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="antibody binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:466780"
     misc_feature    order(905..907,917..919,926..928,938..940,953..955,
                     962..964,1010..1018,1022..1033,1040..1042)
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="antibody binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:466780"
     exon            567..578
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            579..713
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            714..847
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1197
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttctgaat cagctcttct accagcaaac atctcacttc agtgtctctg tgagcactga
       61 attcatcttg tgcactctcc ttacaacaca gctcttctga ccaccagggc acagcctctc
      121 agttggaagt gaaattggaa agagaaactc agtgagctga ctgaacactg gctgtcccca
      181 caacgatgag tacaccaatc ctgttgttcg taaaccaggc tttcacttct cccctgggga
      241 gtgctgcctg catcacacag agaccttcag aagcctgcta taatcttcag gacccacgta
      301 cagcagtcca acggcagact ggcgcagctg taccccaggg tgcagtttct ctgtagctcc
      361 atgctttccg taatcctagc tgcctgctcc agctgctgac aggactgcca tcttctgcaa
      421 cctccaggat caggaaaaag aaagaggcct cgaagcttcc aaatcacttc ctcttggccc
      481 aggaacaatg gctgccatac cagaagaagg ctcttgtgtc aacttcaaag aaatgatgtt
      541 tattgacaac acactttacc ttatacctga agataatgga gacttggaat cagaccactt
      601 tggcagactt cactgtacaa ccgcagtaat gcggagcata aatgaccaag ttctcttcgt
      661 tgacaaaaga aacccgcctg tgttcgagga catgcctgat atcgaccgaa cagccaacga
      721 atcccagacc agactgataa tatatatgta caaagatagt gaagtaagag gactggctgt
      781 gaccctatct gtgaaggatg gaaggatgtc taccctctcc tgtaaaaaca aaatcatttc
      841 ctttgaggaa atgaatccac ctgaaaatat tgatgatata aaaagtgatc tcatattctt
      901 tcagaaacgt gtgccaggac acaacaaaat ggaatttgaa tcttccctgt atgaaggaca
      961 ctttctagct tgccaaaagg aagatgatgc tttcaaactc gttttgaaaa ggaaggatga
     1021 aaatggggat aaatctgtaa tgttcactct tactaactta catcaaagtt aggtattaag
     1081 gtttctgtat tccagaaaga cgattagtat acacgagcct tatgataacc tactctgtat
     1141 ttctatgaca aaatacctga ggccgcatga tttatagagt aaacaagttt aattgtc
//
LOCUS       NM_053304               5843 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus collagen type I alpha 1 chain (Col1a1), mRNA.
ACCESSION   NM_053304 XM_001081230 XM_213440
VERSION     NM_053304.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5843)
  AUTHORS   Cao,Y., Huang,W., Wu,F., Shang,J., Ping,F., Wang,W., Li,Y., Zhao,X.
            and Zhang,X.
  TITLE     ZFP36 protects lungs from intestinal I/R-induced injury and
            fibrosis through the CREBBP/p53/p21/Bax pathway
  JOURNAL   Cell Death Dis 12 (7), 685 (2021)
   PUBMED   34238924
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5843)
  AUTHORS   Lin,G., Wan,X., Liu,D., Wen,Y., Yang,C. and Zhao,C.
  TITLE     COL1A1 as a potential new biomarker and therapeutic target for type
            2 diabetes
  JOURNAL   Pharmacol Res 165, 105436 (2021)
   PUBMED   33497804
  REMARK    GeneRIF: COL1A1 as a potential new biomarker and therapeutic target
            for type 2 diabetes.
REFERENCE   3  (bases 1 to 5843)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   4  (bases 1 to 5843)
  AUTHORS   Yuan,Y., Naito,H., Kitamori,K., Hashimoto,S., Asano,T. and
            Nakajima,T.
  TITLE     The antihypertensive agent hydralazine reduced extracellular matrix
            synthesis and liver fibrosis in nonalcoholic steatohepatitis
            exacerbated by hypertension
  JOURNAL   PLoS One 15 (12), e0243846 (2020)
   PUBMED   33315911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5843)
  AUTHORS   Kananykhina,E.Y., Shmakova,T.V., Bolshakova,G.B., Rusanov,F.S.,
            Elchaninov,A.V., Nikitina,M.P., Lokhonina,A.V., Makarov,A.V. and
            Fatkhudinov,T.K.
  TITLE     Expression of Metalloproteinases and Type I and III Collagens
            during Healing of Excisional Skin Wound on the Abdomen and Back in
            Rats
  JOURNAL   Bull Exp Biol Med 168 (6), 812-816 (2020)
   PUBMED   32328952
  REMARK    GeneRIF: Expression of Metalloproteinases and Type I and III
            Collagens during Healing of Excisional Skin Wound on the Abdomen
            and Back in Rats.
REFERENCE   6  (bases 1 to 5843)
  AUTHORS   Federspiel,S.J., DiMari,S.J., Howe,A.M., Guerry-Force,M.L. and
            Haralson,M.A.
  TITLE     Extracellular matrix biosynthesis by cultured fetal rat lung
            epithelial cells. IV. Effects of chronic exposure to retinoic acid
            on growth, differentiation, and collagen biosynthesis
  JOURNAL   Lab Invest 65 (4), 441-450 (1991)
   PUBMED   1921334
REFERENCE   7  (bases 1 to 5843)
  AUTHORS   Tsuneyoshi,T., Westerhausen,A., Constantinou,C.D. and Prockop,D.J.
  TITLE     Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of
            type I procollagen in lethal osteogenesis imperfecta. The
            conformational strain on the triple helix introduced by a glycine
            substitution can be transmitted along the helix
  JOURNAL   J Biol Chem 266 (24), 15608-15613 (1991)
   PUBMED   1874719
REFERENCE   8  (bases 1 to 5843)
  AUTHORS   Federspiel,S.J., DiMari,S.J., Howe,A.M., Guerry-Force,M.L. and
            Haralson,M.A.
  TITLE     Extracellular matrix biosynthesis by cultured fetal rat lung
            epithelial cells. III. Effects of chronic exposure to epidermal
            growth factor on growth, differentiation, and collagen biosynthesis
  JOURNAL   Lab Invest 64 (4), 463-473 (1991)
   PUBMED   2016852
REFERENCE   9  (bases 1 to 5843)
  AUTHORS   Annoni,G., Arosio,B., Santambrogio,D., Gagliano,N. and Zern,M.A.
  TITLE     Albumin and procollagen type I gene regulation in alcohol and
            viral-induced human liver disease
  JOURNAL   Boll Ist Sieroter Milan 70 (1-2), 391-397 (1991)
   PUBMED   1670041
REFERENCE   10 (bases 1 to 5843)
  AUTHORS   Kulozik,M., Hogg,A., Lankat-Buttgereit,B. and Krieg,T.
  TITLE     Co-localization of transforming growth factor beta 2 with alpha
            1(I) procollagen mRNA in tissue sections of patients with systemic
            sclerosis
  JOURNAL   J Clin Invest 86 (3), 917-922 (1990)
   PUBMED   1697606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB693258.1, BC133728.1, CB579389.1, CO397981.1 and BQ206338.1.
            
            On or before Oct 27, 2007 this sequence version replaced
            XM_213440.4, XM_001081230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z78279.1, BC133728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB693258.1         9-24
            17-4742             BC133728.1         1-4726
            4743-5275           CB579389.1         85-617
            5276-5752           CO397981.1         173-649
            5753-5843           BQ206338.1         1-91                c
FEATURES             Location/Qualifiers
     source          1..5843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5843
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="collagen type I alpha 1 chain"
                     /db_xref="GeneID:29393"
                     /db_xref="RGD:61817"
     exon            1..187
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    100..102
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="upstream in-frame stop codon"
     CDS             112..4473
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="procollagen type I, alpha 1; collagen alpha-1(I)
                     chain; collagen, type I, alpha 1; alpha-1 type I collagen;
                     collagen, type 1, alpha 1; procollagen, type 1, alpha 1;
                     type I-alpha 1 collagen"
                     /codon_start=1
                     /product="collagen alpha-1(I) chain precursor"
                     /protein_id="NP_445756.1"
                     /db_xref="GeneID:29393"
                     /db_xref="RGD:61817"
                     /translation="MFSFVDLRLLLLLGATALLTHGQEDIPEVSCIHNGLRVPNGETW
                     KPDVCLICICHNGTAVCDGVLCKEDLDCPNPQKREGECCPFCPEEYVSPDAEVIGVEG
                     PKGDPGPQGPRGPVGPPGQDGIPGQPGLPGPPGPPGPPGPPGLGGNFASQMSYGYDEK
                     SAGVSVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKN
                     GDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDTGPAGPKG
                     EPGSPGENGAPGQMGPRGLPGERGRPGPPGSAGARGNDGAVGAAGPPGPTGPTGPPGF
                     PGAAGAKGEAGPQGARGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAP
                     GIAGAPGFPGARGPSGPQGPSGAPGPKGNSGEPGAPGNKGDTGAKGEPGPAGVQGPPG
                     PAGEEGKRGARGEPGPSGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGP
                     KGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPAGPPGARGQA
                     GVMGFPGPKGTAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGAPGPAGPAGERGEQG
                     PAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGP
                     AGPRGNNGAPGNDGAKGDTGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPK
                     GADGSPGKDGVRGLTGPIGPPGPAGAPGDKGETGPSGPAGPTGARGAPGDRGEPGPPG
                     PAGFAGPPGADGQPGAKGEPGDTGVKGDAGPPGPAGPAGPPGPIGNVGAPGPKGSRGA
                     AGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPVGKEGGKGPRGETGPAGRPGEVGPP
                     GPPGPAGEKGSPGADGPAGSPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPG
                     KQGPSGASGERGPPGPMGPPGLAGPPGESGREGSPGAEGSPGRDGAPGAKGDRGETGP
                     AGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRGDKGET
                     GEQGDRGIKGHRGFSGLQGPPGSPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNG
                     LPGPIGPPGPRGRTGDSGPAGPPGPPGPPGPPGPPSGGYDFSFLPQPPQEKSQDGGRY
                     YRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGE
                     YWIDPNQGCNLDAIKVYCNMETGQTCVFPTQPSVPQKNWYISPNPKEKKHVWFGESMT
                     DGFQFEYGSEGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKSLL
                     LQGSNEIELRGEGNSRFTYSTLVDGCTSHTGTWGKTVIEYKTTKTSRLPIIDVAPLDI
                     GAPDQEFGMDIGPACFV"
     sig_peptide     112..177
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    202..369
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="von Willebrand factor (vWF) type C domain; Region:
                     VWC; smart00214"
                     /db_xref="CDD:214564"
     misc_feature    202..369
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="von Willebrand factor (vWF) type C domain; Region:
                     VWC; smart00214"
                     /db_xref="CDD:214564"
     misc_feature    277..279
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); glycosylation site"
     misc_feature    400..3729
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     mat_peptide     565..3732
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /product="Collagen alpha-1(I) chain. /id=PRO_0000043359"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5)"
     misc_feature    565..612
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Nonhelical region (N-terminal)"
     misc_feature    565..567
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000269|PubMed:5777344; propagated from
                     UniProtKB/Swiss-Prot (P02454.5);
                     pyrrolidone-carboxylic-acid site"
     misc_feature    592..594
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); phosphorylation site"
     misc_feature    613..3654
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Triple-helical region"
     misc_feature    646..648
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    655..657
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    664..666
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    691..693
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    700..702
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    709..711
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000305|PubMed:4290711; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    754..756
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    <775..>1464
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <775..>1464
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    799..801
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    817..819
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    844..846
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    862..864
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    871..873
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:5411206; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    871..873
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:5411206; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); glycosylation site"
     misc_feature    889..891
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); phosphorylation site"
     misc_feature    943..945
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    952..954
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    970..972
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    997..999
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1015..1017
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1078..1080
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1105..1107
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1114..1116
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    <1180..>1923
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <1180..>1923
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    1195..1197
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1204..1206
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1240..1242
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1258..1260
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1285..1287
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1303..1305
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1312..1314
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1357..1359
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1366..1368
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1384..1386
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1393..1395
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1429..1431
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1456..1458
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1501..1503
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1519..1521
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1546..1548
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1564..1566
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1591..1593
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1618..1620
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1645..1647
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1663..1665
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1681..1683
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1708..1710
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1717..1719
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    <1726..>2370
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <1726..>2370
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    1744..1746
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1771..1773
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1789..1791
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1825..1827
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1852..1854
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1879..1881
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1888..1890
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1942..1944
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    1996..1998
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2014..2016
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2032..2034
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2050..2052
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2068..2070
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2086..2088
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2122..2124
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2149..2151
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2185..2187
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2221..2223
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2230..2232
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    <2242..>3045
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <2242..>3045
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    2248..2250
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2266..2268
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2293..2295
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2311..2319
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Cell attachment site. /evidence=ECO:0000255"
     misc_feature    2329..2331
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2347..2349
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2392..2394
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2410..2412
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2437..2439
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); phosphorylation site"
     misc_feature    2473..2475
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2491..2493
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2500..2502
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2527..2529
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2545..2547
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2599..2601
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2626..2628
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2653..2655
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2662..2664
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2689..2691
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2707..2709
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2731..2733
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="3-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2734..2736
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2761..2763
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2770..2772
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    <2800..>3477
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    <2800..>3477
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     Region: gly_rich_SclB; NF038329"
                     /db_xref="CDD:468478"
     misc_feature    2833..2835
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2860..2862
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2887..2889
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2914..2916
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2968..2970
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    2995..2997
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3004..3006
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3022..3024
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3067..3069
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3085..3087
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3103..3105
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3130..3132
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3148..3150
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3175..3177
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3211..3213
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3220..3222
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3229..3231
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3355..3363
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Cell attachment site. /evidence=ECO:0000255"
     misc_feature    3364..3366
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3400..3402
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3400..3402
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); glycosylation site"
     misc_feature    3436..3438
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3445..3447
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3454..3456
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3508..3510
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P02457; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3553..3555
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3568..3570
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="3-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3571..3573
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3613..3615
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="3-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3616..3618
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3622..3624
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="3-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3625..3627
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3631..3633
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="3-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3634..3636
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3637..3669
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Major antigenic determinant (of neutral
                     salt-extracted rat skin collagen)"
     misc_feature    3643..3645
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3652..3654
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:P11087; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); hydroxylation site"
     misc_feature    3655..3732
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="propagated from UniProtKB/Swiss-Prot (P02454.5);
                     Region: Nonhelical region (C-terminal)"
     misc_feature    3757..4467
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Fibrillar collagen C-terminal domain; Region:
                     COLFI; pfam01410"
                     /db_xref="CDD:460199"
     misc_feature    3757..4467
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="Fibrillar collagen C-terminal domain; Region:
                     COLFI; pfam01410"
                     /db_xref="CDD:460199"
     misc_feature    4171..4173
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P02454.5); glycosylation site"
     exon            188..382
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..414
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..450
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..552
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..621
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..666
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..720
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..774
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..828
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..882
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..936
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..981
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1035
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1080
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1134
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1233
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1278
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1377
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1431
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1539
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1593
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1692
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1746
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1845
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1899
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1953
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2007
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2061
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2106
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2205
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2313
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2421
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2475
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2529
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2637
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2691
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2745
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2907
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3015
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3123
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3177
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3285
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3339
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3447
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3501
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3609
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3892
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4083
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4326
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..5826
                     /gene="Col1a1"
                     /gene_synonym="COLIA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagtttc acctccggac ggagcaggag gcacacggag tgaggccacg catgagccga
       61 agctaacccc ccaccccagc cgcaaagagt ctacatgtct agggtctaga catgttcagc
      121 tttgtggacc tccggctcct gctcctctta ggggccactg ccctcctgac gcatggccaa
      181 gaagacatcc ctgaagtcag ctgcatacac aatggcctaa gggtccctaa tggtgagacg
      241 tggaaacctg atgtatgctt gatctgtatc tgccacaatg gcacggctgt gtgcgatggc
      301 gtgctatgca aagaagactt ggactgtccc aacccccaaa aacgggaggg cgagtgctgt
      361 cctttctgcc cagaagaata tgtatcacca gacgcagaag tcataggagt cgagggaccc
      421 aagggagacc ctggccccca aggcccacgg ggacctgttg gcccccctgg acaagatggc
      481 atccctggac agcctggact tcctggtcct cctggtcccc ccggcccccc cggaccccct
      541 ggtcttggag gaaactttgc ttcccagatg tcctatggct atgatgagaa atcagctgga
      601 gtttccgtgc ctggccccat gggtccttct ggtcctcgtg gtctccctgg cccccctggt
      661 gcacctggtc ctcaaggttt ccaaggcccc cctggtgaac ctggcgagcc tggcgcttca
      721 ggtccaatgg gtccccgagg tccccctggc cctcctggca agaacggaga tgatggggaa
      781 gctggtaagc ctggccgccc tggtgagcgt ggacctcctg gacctcaggg tgctcgtgga
      841 ttgcctggaa cagctggcct ccccggaatg aagggacaca gaggtttcag tggtttggat
      901 ggtgccaaag gagatactgg tcctgctggt cctaagggag agcctggcag tcctggtgaa
      961 aatggagctc ccggccagat gggtccccga ggtctgcctg gtgagagagg tcgccctgga
     1021 ccccctggca gtgctggtgc tcgtggtaac gatggtgctg tcggtgcagc tgggcccccc
     1081 ggtcccaccg gccctactgg ccctcctggc ttccctggtg cagctggtgc taagggtgaa
     1141 gctggtcccc agggagcccg aggctctgaa ggtccccagg gtgtgcgtgg tgagcccgga
     1201 ccccctggcc ctgctggtgc tgctggtcct gctggaaacc ctggtgctga tggacaacct
     1261 ggtgctaaag gtgccaatgg tgctcctggt attgctggtg ctcctggctt ccctggtgcc
     1321 cgaggcccct ctggacctca gggccccagc ggcgctcctg gtcccaaagg caacagtggt
     1381 gaacctggtg cccctggcaa caaaggagac actggtgcca aaggagaacc cggccctgct
     1441 ggagttcaag gtccccctgg ccctgctgga gaagaaggaa aacgaggagc ccgtggtgag
     1501 cctggaccta gcggcctgcc cggacctcct ggcgagcgcg gtggacctgg tagccgtggt
     1561 ttccctggtg ctgatggtgt tgctggcccc aagggtcctg ctggtgaacg tggttctcct
     1621 ggccctgctg gtcccaaagg ttctcctggt gaagctggtc gccctggtga agctggtctc
     1681 cctggtgcca agggtctcac tggcagtcct ggcagccctg gtcctgatgg caaaaccggc
     1741 ccccctggtc ccgctggtca agatggtcgc cctggacccg caggtcctcc tggagcccgt
     1801 ggacaggctg gtgtgatggg attccctgga cctaagggta ctgctggaga acctggaaag
     1861 gctggagaac gaggtgtccc cggaccccct ggcgctgttg gtcccgctgg caaagatggc
     1921 gaagctggag ctcaaggagc ccccggccct gctggtcctg ctggtgagag aggtgaacaa
     1981 ggtcccgctg gctcccctgg attccagggt cttcctggtc ccgctggtcc tcctggtgaa
     2041 gcaggcaagc ctggtgaaca gggtgttcct ggagaccttg gtgcccctgg accctctggc
     2101 gcaagaggcg agagaggttt ccctggtgaa cgtggtgtac aaggtccccc aggtcctgct
     2161 ggtccccgag gaaacaatgg tgcccccggc aacgatggtg ccaagggtga tactggtgcc
     2221 cccggagctc ctggtagcca gggtgccccc ggtcttcagg gaatgcctgg tgaacgtggt
     2281 gcagctggtc ttccaggtcc taagggtgac agaggtgatg ctggtcccaa aggtgctgat
     2341 ggttctcctg gcaaagatgg cgtccgtggt ctgactggtc ccattggtcc tcctggccct
     2401 gctggtgccc ctggtgacaa gggtgaaact ggtcccagtg gtcctgctgg ccccaccgga
     2461 gcccgtggtg cccccggaga ccgtggtgag cctggtcccc ctggtcctgc tggcttcgct
     2521 ggcccccctg gtgctgatgg ccaacctggt gcgaaaggtg aacctggtga tactggtgtg
     2581 aaaggtgacg ctggtcctcc tggccctgct ggtcccgctg gaccccctgg ccccattggt
     2641 aacgttggtg ctcctggacc caaaggttct cgtggtgctg ctggtccccc tggtgctact
     2701 ggtttccctg gtgctgctgg tcgtgttggt ccccctggtc cctctggaaa tgctggaccc
     2761 cctggccctc ccggtcccgt tggcaaagaa gggggcaaag gtccccgtgg tgagactggt
     2821 cccgctggac gtcctggtga agttggtccc ccaggtcccc ctggccctgc tggtgagaaa
     2881 ggatctcctg gtgctgatgg acctgctggc tctcctggta cccctggacc tcagggtatt
     2941 gctggacagc gtggtgtggt cggtcttccc ggtcagagag gagaaagagg cttccctggt
     3001 cttcctggac cctctggtga acccggcaaa caaggtcctt ctggagcaag tggtgaacgt
     3061 ggtccccctg gccctatggg cccccctgga ttggctggcc cccctggtga atctggtcgt
     3121 gagggatccc ctggtgctga aggctcccct ggaagagatg gtgctcctgg tgccaagggt
     3181 gaccgtggtg agactggccc tgctggcccc cctggtgctc ctggtgctcc tggtgctccc
     3241 ggccctgttg gtcctgctgg caagaatggc gaccgtggtg agactggtcc tgctggtcct
     3301 gctggtccca ttggccctgc tggtgcccgt ggtcctgctg gaccccaagg cccccgtggt
     3361 gacaagggtg agacaggcga acaaggtgac agaggcataa agggtcatcg tggcttctct
     3421 ggtctccagg gtcctcctgg ctctcctggc tctcctggtg aacaaggccc ctctggagct
     3481 tctggtcctg caggtccccg gggtccccct ggctctgctg gttctcctgg caaagatgga
     3541 ctcaacggtc tccctggccc cattggtccc cctggtcctc gaggtcgcac tggcgatagt
     3601 ggtcctgctg gtccccccgg acctcctgga ccccctggcc ctcccggtcc tcccagcggt
     3661 ggttatgact tcagcttcct gcctcagcca cctcaagaga agtctcaaga tggtggccgt
     3721 tactaccggg ccgatgatgc caacgtggtc cgtgaccgtg accttgaggt ggacactacc
     3781 ctcaagagcc tgagccagca gattgagaac atccgcagcc ctgagggcag ccgcaagaac
     3841 cccgcccgca catgccgtga cctcaagatg tgccactctg actggaagag cggagagtac
     3901 tggatcgacc ctaaccaagg ctgcaacctg gatgccatca aggtctactg caacatggag
     3961 acaggtcaga cctgtgtgtt ccccactcag ccctctgtgc ctcagaagaa ctggtacatc
     4021 agcccaaacc ccaaggagaa gaagcatgtc tggtttggag agagcatgac cgatggattc
     4081 cagttcgagt atggaagcga aggttccgat cctgccgatg tcgctatcca gctgaccttc
     4141 ctgcgcctga tgtccaccga ggcctcccag aacatcacct atcactgcaa gaacagcgta
     4201 gcctacatgg accaacagac tggcaacctc aagaagtccc tgctcctcca gggctccaac
     4261 gagatcgagc tcaggggcga aggcaacagt cgattcacct acagcacgct tgtggatggc
     4321 tgcacgagtc acaccggaac ttggggcaag acagtcatcg aatacaaaac caccaagacc
     4381 tcccgcctgc ccatcatcga tgtggctccc ttggacattg gtgccccaga ccaggaattc
     4441 ggaatggaca ttggccctgc ctgcttcgtg taaactccct ccatcccaat ctggttccct
     4501 cccacccagc ccactttccc ccaaccctgg aaacagacca acaacccaaa ctcaatttcc
     4561 ccaaaagcca aaaattggga gacaatttca catggacttt ggaaaacatt tttttccttt
     4621 gcattcatct ctcaaactta gtttttatct ttgaccaact gaacgtgacc aaaaaccaaa
     4681 agtgcattca accttaccaa aaagaaaaaa aaataagaat aaataaataa ctttttaaaa
     4741 aaggaagctt ggtcctcttg cttgaagacc tatgtgggta taagtccctt tctgcccact
     4801 gggcttatga taccccaaat gctgcctttt ctgttccttt ctccaccccc tcttggggcc
     4861 tctcctccat tgctccccaa atttaagtct cccccaaaga cacaggaaat aatgcattgt
     4921 ctgcccagcc agcaaaggca atgctgaatc gtcccaccag cccctcaacc cccagcctac
     4981 ttccctaccc agcaccttca aatcctgccg ggacatgggg ttctcggact attgaaggag
     5041 cctaaccatc tggcatctcc atggcctctg caacaaatcc ccacacacac tttgtttttg
     5101 agggcctgtg ctgggggagc cacctgcccc tcgcaggggt ttggagccag gcagggtcac
     5161 agcagactgg aaacatcggc cacacatgtg caggctgggt gggagagact gttctgttcc
     5221 ttgtgtaatt gtgttgctga aagactacct cgttcttgtc tttgtgtgtc accggggcaa
     5281 ctgtgtgggg gcggggatgg gggcagggtg gcagcgcgcc cagtttggta tcaaaggtgc
     5341 tacatctctg tgaaggggtg gggtgggaag gaatttctgg tgctatagaa tctgagatgc
     5401 tcccctagac cagcaaatgt tccttttgtt caaagtattt ttttattctt ttttttttaa
     5461 tggataggga cttgtgtgaa ttttcttttc ctgacggtgc tatttaacaa gggaggagag
     5521 agtgccaact ccagcctgct ctctctctac ccccctcttc actcttccag ctcctgggcc
     5581 tatctgatga tctctctctc ttctgaaacc ctcccctctt gctgctgctc cctaccctca
     5641 gcttctctct ctctctgtcc tgcatcaggg tttcagagca ccattttcca aagcacaaag
     5701 cagtttttat ccctggggtg ggaggaagca agagactctg tacctatttt gtatgtgtat
     5761 aataatttga gatgttttta attattttga ttgctggaat aaagcatgtg gaaatgaccc
     5821 aacgcaaaaa aaaaaaaaaa aaa
//
LOCUS       NM_001393741            7200 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus SRC kinase signaling inhibitor 1 (Srcin1),
            transcript variant 3, mRNA.
ACCESSION   NM_001393741
VERSION     NM_001393741.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7200)
  AUTHORS   Calipari,E.S., Godino,A., Salery,M., Damez-Werno,D.M., Cahill,M.E.,
            Werner,C.T., Gancarz,A.M., Peck,E.G., Jlayer,Z., Rabkin,J.,
            Landry,J.A., Smith,A.C.W., Defilippi,P., Kenny,P.J., Hurd,Y.L.,
            Neve,R.L., Dietz,D.M. and Nestler,E.J.
  TITLE     Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation
            Mediate Structural and Behavioral Adaptations During Withdrawal
            From Cocaine Self-Administration
  JOURNAL   J Neurosci 39 (29), 5634-5646 (2019)
   PUBMED   31092585
REFERENCE   2  (bases 1 to 7200)
  AUTHORS   Wang,W., Zhu,X., Du,X., Xu,A., Yuan,X., Zhan,Y., Liu,M. and Wang,S.
  TITLE     MiR-150 promotes angiogensis and proliferation of endothelial
            progenitor cells in deep venous thrombosis by targeting SRCIN1
  JOURNAL   Microvasc Res 123, 35-41 (2019)
   PUBMED   30315850
  REMARK    GeneRIF: Upregulation of miR-150 promoted angiogenesis and
            proliferation of endothelial progenitor cells by targeting SRCIN1
            in vitro and thrombus resolution in vivo.
REFERENCE   3  (bases 1 to 7200)
  AUTHORS   Li,M.Y., Miao,W.Y., Wu,Q.Z., He,S.J., Yan,G., Yang,Y., Liu,J.J.,
            Taketo,M.M. and Yu,X.
  TITLE     A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes
            in Stabilizing Spines and Functional Synapses in the Neocortex
  JOURNAL   Neuron 94 (6), 1155-1172 (2017)
   PUBMED   28641114
  REMARK    GeneRIF: Study demonstrates a critical role of presynaptic
            cadherin/catenin/p140Cap cell adhesion complexes in stabilizing
            functional synapses and spines in the developing neocortex.
REFERENCE   4  (bases 1 to 7200)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   5  (bases 1 to 7200)
  AUTHORS   Repetto,D., Camera,P., Melani,R., Morello,N., Russo,I.,
            Calcagno,E., Tomasoni,R., Bianchi,F., Berto,G., Giustetto,M.,
            Berardi,N., Pizzorusso,T., Matteoli,M., Di Stefano,P., Missler,M.,
            Turco,E., Di Cunto,F. and Defilippi,P.
  TITLE     p140Cap regulates memory and synaptic plasticity through
            Src-mediated and citron-N-mediated actin reorganization
  JOURNAL   J Neurosci 34 (4), 1542-1553 (2014)
   PUBMED   24453341
  REMARK    GeneRIF: we here demonstrate that p140Cap is a key element for both
            learning and synaptic plasticity
REFERENCE   6  (bases 1 to 7200)
  AUTHORS   Di Stefano,P., Damiano,L., Cabodi,S., Aramu,S., Tordella,L.,
            Praduroux,A., Piva,R., Cavallo,F., Forni,G., Silengo,L., Tarone,G.,
            Turco,E. and Defilippi,P.
  TITLE     p140Cap protein suppresses tumour cell properties, regulating Csk
            and Src kinase activity
  JOURNAL   EMBO J 26 (12), 2843-2855 (2007)
   PUBMED   17525734
REFERENCE   7  (bases 1 to 7200)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 7200)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   9  (bases 1 to 7200)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   10 (bases 1 to 7200)
  AUTHORS   Chin,L.S., Nugent,R.D., Raynor,M.C., Vavalle,J.P. and Li,L.
  TITLE     SNIP, a novel SNAP-25-interacting protein implicated in regulated
            exocytosis
  JOURNAL   J Biol Chem 275 (2), 1191-1200 (2000)
   PUBMED   10625663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2024 this sequence version replaced NM_001393741.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000010.1  83064930-83065086   c
            158-459             JAXUCZ010000010.1  83042607-83042908   c
            460-483             JAXUCZ010000010.1  83033243-83033266   c
            484-679             JAXUCZ010000010.1  83027327-83027522   c
            680-878             JAXUCZ010000010.1  83026569-83026767   c
            879-972             JAXUCZ010000010.1  83025923-83026016   c
            973-1832            JAXUCZ010000010.1  83024668-83025527   c
            1833-1925           JAXUCZ010000010.1  83024142-83024234   c
            1926-1969           JAXUCZ010000010.1  83023875-83023918   c
            1970-2160           JAXUCZ010000010.1  83023438-83023628   c
            2161-2336           JAXUCZ010000010.1  83022133-83022308   c
            2337-2467           JAXUCZ010000010.1  83017044-83017174   c
            2468-2615           JAXUCZ010000010.1  83016795-83016942   c
            2616-2862           JAXUCZ010000010.1  83016285-83016531   c
            2863-3097           JAXUCZ010000010.1  83015612-83015846   c
            3098-3252           JAXUCZ010000010.1  83013471-83013625   c
            3253-3405           JAXUCZ010000010.1  83013106-83013258   c
            3406-3552           JAXUCZ010000010.1  83008702-83008848   c
            3553-7200           JAXUCZ010000010.1  82999295-83002942   c
FEATURES             Location/Qualifiers
     source          1..7200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..7200
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
     exon            1..157
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3555
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="isoform 3 is encoded by transcript variant 3;
                     p130Cas-associated protein; SNAP25-interacting protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1 isoform 3"
                     /protein_id="NP_001380670.1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
                     /translation="MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPE
                     RSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEAL
                     SGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGA
                     QPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVL
                     FLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFY
                     ELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSP
                     ASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPT
                     SQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAG
                     DPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSS
                     PQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGA
                     STAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRG
                     SEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRL
                     QMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQED
                     PLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKAL
                     VLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTL
                     AQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEG
                     TPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQ
                     AELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYR
                     TEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVK
                     LRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAA
                     QGPAGSPDKGKHGKQRTEYMRIQAQQQ"
     misc_feature    88..273
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    172..174
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    187..189
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    268..270
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    289..291
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    292..294
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    325..327
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    565..567
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    631..633
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    643..645
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    673..675
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    688..>927
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    688..>927
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    811..813
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    859..861
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    988..1278
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1030..1032
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1057..1059
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1108..1110
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1123..1125
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1144..1146
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1165..1167
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1222..1224
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1228..1230
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1324..1326
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1534..2061
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1612..1614
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1621..1623
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1633..1635
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1636..1638
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1642..1644
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1672..1674
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1678..1680
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1684..1686
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1699..1701
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1924..1926
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1996..1998
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2005..2007
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2044..2046
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2074..2226
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Interaction with SNAP25.
                     /evidence=ECO:0000269|PubMed:10625663"
     misc_feature    <2191..2655
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <2191..2655
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    2665..2667
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2704..2880
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2731..2733
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2785..2787
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2980..3228
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3094..3096
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3262..3264
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3313..3315
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3454..3522
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            158..459
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            460..483
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            484..679
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            680..878
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            879..972
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1832
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1925
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1969
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2160
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2336
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2467
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2615
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2862
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3097
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3252
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3405
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3552
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..7200
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggtgcg cgcccccagc cccacgcctc cccatgcagc cctggcagtg cctccggcgc
       61 tttgccctgg cctggtggga gaggaccgcc gagggtcgcg cccgttctcc cagggaggag
      121 gttggaccga gggaccctgg gggccgaggg gagccagatc cggagcggag cagccccccc
      181 atgctgtctg ccgacgatgc cgaatatcct cgggagtacc ggaccctggg gggtgggggc
      241 agcgggggca gcgggggccg gcgcttctcc aacgtggggc tggtgcacac ctccgagcgg
      301 cggcacacgg tgatcgctgc ccagagcctg gaggccctca gcgggctcca gaaggccgat
      361 gctgaccgca agcgagatgc gtttatggac cacctgaaga gcaagtaccc ccagcatgcc
      421 ctggcccttc gaggtcagca ggacaggatg agagagcagc aaccaaacta ctggagtttc
      481 aagacccgca gctcgcgcca tactcaggga gcccagccag ggctggcaga ccaggcagcc
      541 aagctgtcct acgcctcggc tgagtcgctg gagacaatgt ccgaggccga gctgcccctg
      601 ggcttcagca ggatgaatcg cttccgacag agcttgcctc tctcccgctc tgccagccag
      661 accaagctgc gctcaccagg agtcctgttc ctgcagttcg gggaggagac gcgacgtgta
      721 cacatcacgc atgaggtcag cagcctggac acgctgcacg cactcatcgc gcacatgttc
      781 ccgcagaagc tcaccatggg catgcttaag tcgcccaaca ccgccatcct catcaaggac
      841 gaggctcgca acgtcttcta cgagctggaa gacgtccggg atatccagga ccggagtatc
      901 atcaagatct ataggaagga gccactgtat gccgcttttc ctggctcgca cctcaccaac
      961 ggtgacctcc ggagagagat ggtttacgca tcgcgggagt cgtcgcccac gcggcgcctc
     1021 aacaacctgt cgcccgcatc gcacctagca tctagctccc cgcctccagg gctgccatcc
     1081 gggctgcctt cgggactgcc atcgggctcg ccctcgcgtt cacgcctctc gtatgctggg
     1141 ggccggccgc cctcttacgc cggcagcccg gtacaccacg cggctgagcg actgggaggc
     1201 gccccgacca gccagggcgt gagccccagc cccagcgcca tcctggagcg gcgcgacgtg
     1261 aagccagatg aggatctggc gggcaaggcg ggcggcatgg tgctggtgaa gggcgagggc
     1321 ctctatgccg atccctacgg gctgctgcac gagggccgct tgagcctggc cgccgcagca
     1381 ggagacccgt tcgcataccc gggcgcgggc ggcttgtaca agcggggttc tgtgcgctcg
     1441 ctcagcacct actcggccgc tgcgctgcag tccgacctgg aggactcgct gtacaaggcg
     1501 ggcgccggcg gcccgctcta cggagacggc tatggcttcc gtctgccgcc ttcgtccccg
     1561 cagaaactag ccgacgtctc agcgccctcc gggggacctc cgccaccgca cagcccctac
     1621 tctgggccgc ccagccgcgg ctcgccggtg cgccagtcgt tccgtaaaga ttctggttcc
     1681 tcgtcggtct ttgctgagag tcctggaggc aaagcccgca gcaccggggc ttccacggcc
     1741 ggagcaccac cttctgaact cttccctgga cctggagagc gctccctcgt agggttcggg
     1801 ccgccggtgc cagccaagga cacagagacc agggagcgta tggaggccat ggagaagcag
     1861 attgccagcc tcactgggct agtacagagt gctttactgc gaggctcgga gccggagacc
     1921 ccaagtgaga agattgaagg ctccaatgga gcagccaccc cctcagcacc agtgtgtggg
     1981 tcaggcagta ggagtagcgg ggccactcca gtgtcgggcc ctcccccacc cgcggtcagc
     2041 agcacccctg cagggcagcc cactgctgtc agccggctgc aaatgcagat gcatctgcgt
     2101 ggcctacaga acagcgctag cgacctgcgt ggccagcttc agcagttgcg gaagctccag
     2161 ctccagaacc aggagtcggt gcgcgcgctg ctgaagcgca ccgaggcgga gctgagcatg
     2221 cgcgtgtcgg aggcggcgcg gcggcaggag gacccgctgc agcggcagcg caccctggtg
     2281 gaagaggagc gtttgcgtta cctcaacgac gaggagctca ttacacagca gctcaatgac
     2341 ctggagaagt cagtggagaa gatccagagg gatgtggccc ataaccaccg gctggtgcct
     2401 ggtcctgagt tggaagagaa ggctctggtg ctgaaacagc ttggggagac gctgacggaa
     2461 ctcaaggctc atttcccagg cctgcagagt aagatgcggg tagtgctgcg tgtagaggtg
     2521 gaggcagtca agtttctgaa ggaggaacct caacgcctcg acgggcttct caagcgctgc
     2581 cgggtggtca ctgacacgct ggcccagatc cgaaggcaag tggatgaggg tgtgtggcct
     2641 ccccccaaca atctcctgaa ccagtccccc aagaaggtgg cagccgaaac agacttcagc
     2701 aaaggcctgg attttgagat accacccccg agtcctccac tgaatctcca cgagctgagc
     2761 gggcctgcgg aaggcacccc gcttacccca aaaagcggca accctaccaa aggcctggat
     2821 gctccgagca agagaaacat ggacaaagct gtgtctgtcg aggctgcaga gagagactgg
     2881 gaagagaagc gggccgccct gacccagtac agcgccaagg acatcaaccg gctgctggag
     2941 gaaacccaag ctgagctgct caaggctatc cccgacctgg actgtgccag caagacccac
     3001 ccaggcccta ctcccactcc agaccacaag ccccctaagg caccccatgg tcagaaggct
     3061 gctccccgga cagagcccag tgggagaaga ggatcagatg agctcacagt gccccgatac
     3121 cgcacagaga agccctccaa gtcgcccccg ccaccccctc cccgccggag cttcccttcc
     3181 tcgcacggcc tgaccaccac tcgcaccgga gaagtggtgg tcaccagtaa gaaagactca
     3241 gtcttcatca agaaggctga atctgaggag ctggagatcc agaagcctca ggtgaagctg
     3301 cgtcgcgctg tgtctgaggt ggtccgcccc gcgtccacac cgcccattat ggcctcggcc
     3361 atcaaggatg aagacgatga ggaacgcatc attgctgagc tggagagtgg tggtggcagt
     3421 gtgccaccca tgaaggtggt gactcccgga gcctctcggc tgaaggcggc ccagggtcca
     3481 gcaggcagcc ctgataaagg caaacacggc aagcaacgaa cggaatacat gaggatccag
     3541 gcccagcagc agtaaccatg gactgaaccc acaccccact ctgctttcca ggcctttgat
     3601 ccaaccccat ggctcccctc aatcttcttt gtgccctgct gacacacttc cctgccccgt
     3661 tcccccagtt cagaggagcg tcctctccag ctgcccagcc cctcctgggt tctcgctttt
     3721 gcagttagtt ttctctcagc cttgtggagt ttccccattt ttcaacactt cagccaggag
     3781 ccagcacgga ggctctccta tgctctctct gacccctgac ccctgttttt gttccaggcc
     3841 actaaaccat ctaaagagat gagcggtccg aatgagacct caagccccgt ctcagaaaaa
     3901 ccctctggtt ccagaacctc catccctgta ttgacttcct ttggggcaag gaattcttcc
     3961 atctccttct agaagcccct catgccacca ccccagcctg cccctccttt attcctgcca
     4021 tcgtccctcc tttcatgctc taccctcttc actctctcgc ctgaagggtt gcagggggca
     4081 tggccctctg ctctctcatc tcctcttggt gtttttggtt tttttaagcg atttcctttt
     4141 aattatcttc cttttccttt ttcttttttt aaagagtaaa agagaaagct aaaaaccaaa
     4201 cacaccaacg tcccctcact tcctgttccc cagcgggcct ctgctccgcc cacttcctgt
     4261 cattttcccc cttctgctcc gcccacttcc tgtcatcttc ttcccctctg ctctttcacc
     4321 ctttcccccc acccccaagt ccatccaaag ttcccacctc ccctaacttc ccaagaacac
     4381 ttggaacaaa ctctgagcca cggagacttg gagcggagcg agaccccctc ccatttactg
     4441 ggttccttcc tggaggaaca aatggacaag gactgactca gcgtcaggct ggacaatgga
     4501 caagggagac cctggccttg gagacgcccc actgtctgtc cagccttcga agagacagaa
     4561 ctctgctgct ggcctgtggt ttttctttcg aaccagggtg ggcctggaag caggcctagc
     4621 tggaggggat tcccagagaa gaggccaagg ctgggtgtga ggagggaagg gggtgggggg
     4681 gacactaggt gccaggggag aagctggctc actgctgctc agtgtccggc tggtgctagc
     4741 aacaaataga aggaggtccc caagacacct gttatggagg gtgcttctgg ggacagcctg
     4801 cccctggggt tctgccttgg gagagggcaa ccctgagagg ggcaactggt acttttagtt
     4861 ccctaattta gcactttaaa tgccattaac ttattttgtg ggggtggggt ggggaagatg
     4921 gaagggccta gaactatgtt tggagggtgg gaagggtctg ctttgaggga tacagggaga
     4981 agggttgggt gggtgcagta aagtctctga cccctagggg gagcaacttg accttcagcc
     5041 agcctctatg attcgagggt tttcagggaa ggggtgagat gtgacttgcc tgtagggatc
     5101 tggtgaccac tcgtcaggtg tttgagggtc cccaaggcag aagagccagc tagtactcca
     5161 gtctggatac cttgcagggg tcctgcacag ggcagactga cttttgcgtg ggtccaggag
     5221 tcaaagggag aggctgactt ggttctggcc tggcccccag caagtacaga ggggccagag
     5281 cgaaaaggat tacggagagg gctggaaggg tggagggggt cccctttgga gcacaaagca
     5341 gagtaagcac agagatgtgg tcttgggact agtcccacag taagcacaga gaggaaccat
     5401 tgaagggaca gaaccccaag accctggagc ccagcagggg agagccagtg gcagctgttg
     5461 acggtttggg gagggaggga aaactgggtt gtgtttcttt tctttgattt cgttcgtttt
     5521 tatttctttc tctttgtttt attggtttgc tcttgttttc tagctttgaa tcatttttgt
     5581 actaaggcaa gcaagccttt ttgaaaaata acaaaagaag aagaaaaaaa aatccctccc
     5641 agaaaaaaac aaaacgaaaa aaaaaaaaaa aacaaaaaac aaaataaaaa aaaccaaaaa
     5701 aagccctaaa aaatagaaaa aaaaggacct cacaatgatg caattacttt taattgcaag
     5761 taactcttta catttaagtg aagtgtctta acattttata ttgttttaaa aatatattta
     5821 catattatat atatataata tacgtaatat aaatatatat aaatatttaa aaaagaaaaa
     5881 aaaaaaaaag aaaaccacag cacactctcc ctggccgctg tctggcaagg gaggggctgg
     5941 ggacaggcgt atggcctggt gtccatagtc cccgtgaagc agtttggttt gatttggctg
     6001 tacagagacc cctggcttgg gaggggaggg ggagggcccc tccactccat ttctctttgc
     6061 ttgctactct ttgcttgccc ccacacccgc tcagccctgt gacctgagtc tgcgcccctc
     6121 cgtcattgtc ctgagttgag tgtccttcgt ggagagaggg gatgccggag gaagtgacca
     6181 tccacgtagg ggctgcccca cgagctcagg caaggcccgt gggatttgcg tagttctagt
     6241 tcttcgattt ggttcctgcg cacgtgtgtc ctggaaggca tttgtgtggg tttgtgtgca
     6301 cgtgtgtgtg cacgctggca caagcctaca taacttgtgt gtgcacatgc atggattgtg
     6361 tgtgcatagg ccaaacttaa tattgtatgt ggaagccttg tacatgtatg tgaacatcac
     6421 ctgcctggac atcacagcat gattgtgtga ggagagcctt gggagtaaga acatgtgtaa
     6481 tgtgtgtgtg gacgtgcctg gctgttcttg tgaggcccac atatggatgg gtacagtaac
     6541 cttagctgtg ggtatggttg tgcaggcagg tgtgtgagag ggcctctgtg tgtgtgtgag
     6601 tactcgtgtg catgtgtgtg cgcgcgcgtt ccatcatccc tgcaccactc gcccggctcc
     6661 cctcccaagc tccgccccca cccgccttct caaagcccac agcacgtcaa tccccgcccc
     6721 ctggccccca ggcccccagc tgcatgcgcc tcgccgctgt ccatcagtgt gtgcttgaca
     6781 agagaaactg ccacatcggg gaccctgtac ctggtcccct cacccctgcc cgctgtgctg
     6841 tgttactcgc atgggggggt tctctctgcc cccttccaca atatactgtt tccctagggg
     6901 cctcggggcc aaggctttga gtgaggtccc aagtggggtc ccccaaggcc agcccggctc
     6961 cacacccacc cgtccacccc gtagggcctg tgttggtgta gaagtgatgg cttctgtgga
     7021 tattgtgacc tctgtcagtg taacttgaca atttttaaat ggaaagggtt gctgtgtttt
     7081 ctgtctcttt tttaatgtcc ttcttttctt ccctacctcc cgctctcttc cctttccttt
     7141 tggtttttct agccgagtgt tggggcttta ataaaacttg tttccttttt ctctccggga
//
LOCUS       NM_053469                360 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus hepcidin antimicrobial peptide (Hamp), mRNA.
ACCESSION   NM_053469
VERSION     NM_053469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Flores,S.R.L., Nelson,S., Woloshun,R.R., Wang,X., Ha,J.H.,
            Lee,J.K., Yu,Y., Merlin,D. and Collins,J.F.
  TITLE     Intestinal iron absorption is appropriately modulated to match
            physiological demand for iron in wild-type and iron-loaded Hamp
            (hepcidin) knockout rats during acute colitis
  JOURNAL   PLoS One 16 (6), e0252998 (2021)
   PUBMED   34143808
  REMARK    GeneRIF: Intestinal iron absorption is appropriately modulated to
            match physiological demand for iron in wild-type and iron-loaded
            Hamp (hepcidin) knockout rats during acute colitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Pourmohammad,P., Alipanah-Moghadam,R., Nemati,A., Malekzadeh,V. and
            Mahmoodzadeh,Y.
  TITLE     Comparison of the effects of zinc oxide and zinc oxide
            nanoparticles on the expression of hepcidin gene in rat liver
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 43-48 (2020)
   PUBMED   33544508
  REMARK    GeneRIF: Comparison of the effects of zinc oxide and zinc oxide
            nanoparticles on the expression of hepcidin gene in rat liver.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 360)
  AUTHORS   Huang,Y., Zhang,H., Wang,C., Zhou,J., Li,Y. and Hu,C.
  TITLE     DNA methylation suppresses liver Hamp expression in response to
            iron deficiency after bariatric surgery
  JOURNAL   Surg Obes Relat Dis 16 (1), 109-118 (2020)
   PUBMED   31839527
  REMARK    GeneRIF: DNA methylation suppresses liver Hamp expression in
            response to iron deficiency after bariatric surgery.
REFERENCE   4  (bases 1 to 360)
  AUTHORS   Liu,J., Wan,M., Zhang,Y., Zhang,S., Zhang,H. and Wu,S.
  TITLE     Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the
            Rat Hippocampus After Heat Stroke
  JOURNAL   Shock 51 (6), 780-786 (2019)
   PUBMED   29757912
  REMARK    GeneRIF: ata thereby indicate that heat stroke can decrease
            learning ability and memory in rats. The mechanism may be related
            to changes of iron levels, as well as Fpn1 and hepcidin expression,
            in the hippocampus.
REFERENCE   5  (bases 1 to 360)
  AUTHORS   Marmur,J., Beshara,S., Eggertsen,G., Onelov,L., Albiin,N.,
            Danielsson,O., Hultcrantz,R. and Stal,P.
  TITLE     Hepcidin levels correlate to liver iron content, but not
            steatohepatitis, in non-alcoholic fatty liver disease
  JOURNAL   BMC Gastroenterol 18 (1), 78 (2018)
   PUBMED   29871592
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 360)
  AUTHORS   Nicolas,G., Bennoun,M., Devaux,I., Beaumont,C., Grandchamp,B.,
            Kahn,A. and Vaulont,S.
  TITLE     Lack of hepcidin gene expression and severe tissue iron overload in
            upstream stimulatory factor 2 (USF2) knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8780-8785 (2001)
   PUBMED   11447267
REFERENCE   7  (bases 1 to 360)
  AUTHORS   Pigeon,C., Ilyin,G., Courselaud,B., Leroyer,P., Turlin,B.,
            Brissot,P. and Loreal,O.
  TITLE     A new mouse liver-specific gene, encoding a protein homologous to
            human antimicrobial peptide hepcidin, is overexpressed during iron
            overload
  JOURNAL   J Biol Chem 276 (11), 7811-7819 (2001)
   PUBMED   11113132
REFERENCE   8  (bases 1 to 360)
  AUTHORS   Park,C.H., Valore,E.V., Waring,A.J. and Ganz,T.
  TITLE     Hepcidin, a urinary antimicrobial peptide synthesized in the liver
  JOURNAL   J Biol Chem 276 (11), 7806-7810 (2001)
   PUBMED   11113131
REFERENCE   9  (bases 1 to 360)
  AUTHORS   Krause,A., Neitz,S., Magert,H.J., Schulz,A., Forssmann,W.G.,
            Schulz-Knappe,P. and Adermann,K.
  TITLE     LEAP-1, a novel highly disulfide-bonded human peptide, exhibits
            antimicrobial activity
  JOURNAL   FEBS Lett 480 (2-3), 147-150 (2000)
   PUBMED   11034317
REFERENCE   10 (bases 1 to 360)
  AUTHORS   Venta,P.J., Montgomery,J.C., Hewett-Emmett,D., Wiebauer,K. and
            Tashian,R.E.
  TITLE     Structure and exon to protein domain relationships of the mouse
            carbonic anhydrase II gene
  JOURNAL   J Biol Chem 260 (22), 12130-12135 (1985)
   PUBMED   2995362
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053469.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF344185.1, AW534367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000001.1  95300168-95300271   c
            105-167             JAXUCZ010000001.1  95298608-95298670   c
            168-360             JAXUCZ010000001.1  95298332-95298524   c
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..360
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /note="hepcidin antimicrobial peptide"
                     /db_xref="GeneID:84604"
                     /db_xref="RGD:70971"
     exon            1..104
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..272
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /codon_start=1
                     /product="hepcidin precursor"
                     /protein_id="NP_445921.1"
                     /db_xref="GeneID:84604"
                     /db_xref="RGD:70971"
                     /translation="MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAES
                     KTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT"
     sig_peptide     18..86
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    111..269
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /note="Region: Hepcidin; pfam06446"
                     /db_xref="CDD:461915"
     misc_feature    111..269
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /note="Region: Hepcidin; pfam06446"
                     /db_xref="CDD:461915"
     mat_peptide     195..269
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /product="Hepcidin. /id=PRO_0000013386"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MH3.1)"
     exon            105..167
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
     exon            168..360
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggacaga aggcaagatg gcactaagca ctcggatcca ggctgcctgt ctcctgcttc
       61 tcctcctggc cagcctgagc agcggtgcct atctccggca acagacgaga cagactacgg
      121 ctctgcagcc ttggcatggg gcagaaagca agactgatga cagtgcgctg ctgatgctga
      181 agcgaaggaa gcgagacacc aacttcccca tatgcctctt ctgctgtaaa tgctgtaaga
      241 attcctcctg tggtctctgt tgcataacat agagagccaa gagccttgtc ctgacctctc
      301 aacacactgc ctcccctccg ccccattatt tattcctgtc ctaccccagc aatgaccttg
//
LOCUS       NM_022277               2521 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus caspase 8 (Casp8), mRNA.
ACCESSION   NM_022277
VERSION     NM_022277.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Lu,E., Zhuo,Q., Chen,F., Lin,Q. and Wang,X.
  TITLE     [Role of caspase-8 in stem cell transplantation alleviates rat
            cerebral cortex apoptosis after cardiopulmonary resuscitation]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 34 (12), 1280-1284 (2022)
   PUBMED   36567583
  REMARK    GeneRIF: [Role of caspase-8 in stem cell transplantation alleviates
            rat cerebral cortex apoptosis after cardiopulmonary resuscitation].
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Martin,S., Harrington,D.A., Ohlander,S., Stupp,S.I., McVary,K.T.
            and Podlasek,C.A.
  TITLE     Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog
            protein to the penis and cavernous nerve suppresses intrinsic and
            extrinsic apoptotic signaling mechanisms, which are an underlying
            cause of erectile dysfunction
  JOURNAL   Nanomedicine 37, 102444 (2021)
   PUBMED   34314869
  REMARK    GeneRIF: Peptide amphiphile nanofiber hydrogel delivery of Sonic
            hedgehog protein to the penis and cavernous nerve suppresses
            intrinsic and extrinsic apoptotic signaling mechanisms, which are
            an underlying cause of erectile dysfunction.
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Yang,X., Zeng,Q. and Tezel,G.
  TITLE     Regulation of distinct caspase-8 functions in retinal ganglion
            cells and astroglia in experimental glaucoma
  JOURNAL   Neurobiol Dis 150, 105258 (2021)
   PUBMED   33434617
  REMARK    GeneRIF: Regulation of distinct caspase-8 functions in retinal
            ganglion cells and astroglia in experimental glaucoma.
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Wang,H., Yu,Q., Zhang,Z.L., Ma,H. and Li,X.Q.
  TITLE     Involvement of the miR-137-3p/CAPN-2 Interaction in
            Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation
            of p35 Cleavage and Subsequent Caspase-8 Overactivation
  JOURNAL   Oxid Med Cell Longev 2020, 2616871 (2020)
   PUBMED   33456665
  REMARK    GeneRIF: Involvement of the miR-137-3p/CAPN-2 Interaction in
            Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation
            of p35 Cleavage and Subsequent Caspase-8 Overactivation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Nakagawa,T., Zhu,H., Morishima,N., Li,E., Xu,J., Yankner,B.A. and
            Yuan,J.
  TITLE     Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and
            cytotoxicity by amyloid-beta
  JOURNAL   Nature 403 (6765), 98-103 (2000)
   PUBMED   10638761
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Estelles,A., Charlton,C.A. and Blau,H.M.
  TITLE     The phosphoprotein protein PEA-15 inhibits Fas- but increases
            TNF-R1-mediated caspase-8 activity and apoptosis
  JOURNAL   Dev Biol 216 (1), 16-28 (1999)
   PUBMED   10588860
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Lin,Y., Devin,A., Rodriguez,Y. and Liu,Z.G.
  TITLE     Cleavage of the death domain kinase RIP by caspase-8 prompts
            TNF-induced apoptosis
  JOURNAL   Genes Dev 13 (19), 2514-2526 (1999)
   PUBMED   10521396
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Sanchez,I., Xu,C.J., Juo,P., Kakizaka,A., Blenis,J. and Yuan,J.
  TITLE     Caspase-8 is required for cell death induced by expanded
            polyglutamine repeats
  JOURNAL   Neuron 22 (3), 623-633 (1999)
   PUBMED   10197541
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Sakamaki,K., Tsukumo,S. and Yonehara,S.
  TITLE     Molecular cloning and characterization of mouse caspase-8
  JOURNAL   Eur J Biochem 253 (2), 399-405 (1998)
   PUBMED   9654089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 18, 2024 this sequence version replaced NM_022277.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279308.1, SRR26643299.39425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000009.1  67758021-67758309
            290-622             JAXUCZ010000009.1  67786858-67787190
            623-728             JAXUCZ010000009.1  67790174-67790279
            729-867             JAXUCZ010000009.1  67791507-67791645
            868-921             JAXUCZ010000009.1  67791726-67791779
            922-983             JAXUCZ010000009.1  67794221-67794282
            984-1125            JAXUCZ010000009.1  67796281-67796422
            1126-1630           JAXUCZ010000009.1  67803544-67804048
            1631-2521           JAXUCZ010000009.1  67805809-67806699
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2521
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="caspase 8"
                     /db_xref="GeneID:64044"
                     /db_xref="RGD:620945"
     exon            1..289
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    261..263
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="upstream in-frame stop codon"
     exon            290..622
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1766
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /EC_number="3.4.22.61"
                     /codon_start=1
                     /product="caspase-8"
                     /protein_id="NP_071613.1"
                     /db_xref="GeneID:64044"
                     /db_xref="RGD:620945"
                     /translation="MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVL
                     FQRLQEEGMLEEDNLSFLKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYR
                     VMLFKLSEDMDKEDLKSFKFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTL
                     KSICFRVNRSLLGRIDDYERSSTERRMSTEGGEELPVSVLDEVTIKMQDMWDSPGEQE
                     SESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTF
                     KELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFICCILSHGDKGIVYGTDGKEAS
                     IYELTSYFTGSKCPSLAGKPKIFFIQACQGNNFQKAVPVPDETGLEQEHVLEEDSSSY
                     KNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSLRERCPRGEDILSILTGVN
                     YDVSNKDNPRNMGKQMPQPIFTLRKKLFFPPN"
     misc_feature    324..569
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Death effector domain, repeat 1, of Caspase-8;
                     Region: DED_Caspase_8_r1; cd08333"
                     /db_xref="CDD:260041"
     misc_feature    324..569
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Death effector domain, repeat 1, of Caspase-8;
                     Region: DED_Caspase_8_r1; cd08333"
                     /db_xref="CDD:260041"
     misc_feature    order(363..368,378..380,387..392,396..401,507..509,
                     519..521)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="putative DED1/DED2 interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:260041"
     misc_feature    order(363..368,378..380,387..392,396..401,507..509,
                     519..521)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="putative DED1/DED2 interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:260041"
     misc_feature    609..854
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; Region: DD; cl14633"
                     /db_xref="CDD:472698"
     misc_feature    609..854
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; Region: DD; cl14633"
                     /db_xref="CDD:472698"
     misc_feature    879..881
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O89110; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1); phosphorylation site"
     misc_feature    954..956
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O89110; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1); phosphorylation site"
     misc_feature    969..974
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Cleavage, by autocatalytic cleavage.
                     /evidence=ECO:0000250|UniProtKB:Q14790; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1)"
     misc_feature    996..1757
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    996..1757
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; Region: CASc;
                     cd00032"
                     /db_xref="CDD:237997"
     misc_feature    order(1101..1103,1275..1277,1395..1397,1416..1418,
                     1554..1571,1581..1586)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1101..1103,1275..1277,1395..1397,1416..1418,
                     1554..1571,1581..1586)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="substrate pocket [chemical binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1272..1274,1401..1403)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    order(1272..1274,1401..1403)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="active site"
                     /db_xref="CDD:237997"
     misc_feature    1323..1325
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q14790; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1); phosphorylation site"
     misc_feature    order(1419..1421,1509..1514,1533..1535,1542..1544,
                     1551..1553,1620..1622,1647..1649,1665..1667,1707..1709,
                     1722..1727,1731..1733,1740..1745)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1419..1421,1509..1514,1533..1535,1542..1544,
                     1551..1553,1620..1622,1647..1649,1665..1667,1707..1709,
                     1722..1727,1731..1733,1740..1745)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:237997"
     misc_feature    order(1422..1424,1506..1508)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    order(1422..1424,1506..1508)
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     misc_feature    1443..1448
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Cleavage, by CASP6.
                     /evidence=ECO:0000250|UniProtKB:Q14790; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1); cleavage site"
     misc_feature    1479..1484
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Cleavage, by autocatalytic cleavage.
                     /evidence=ECO:0000250|UniProtKB:Q14790; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1)"
     misc_feature    1485..1487
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000250|UniProtKB:Q14790; propagated from
                     UniProtKB/Swiss-Prot (Q9JHX4.1); phosphorylation site"
     exon            623..728
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            729..867
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            868..921
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            922..983
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1125
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1630
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2521
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaactggc gggcgctcct aaggcgggca gagagaagca gcctatgcca cctagtgatt
       61 atcagaaatt agtcatttct gctccttagt tctctcagtt gcctttctcc tccctctgac
      121 ctccggtgtt ttatagttcc gcttctttga atccatagta aactttggcg gactggccag
      181 ggaacaggaa gtgagcccgg ctagcggcag ccggaggcgg agagcgtctc ccaggggttg
      241 ctcgcccgag aggggagctg tgactggcgg ggcagggact cggcgacagg ttacagctct
      301 cctacccctt ggtaagaatg gatttccaca gttgtcttta cgatattgct gaacgtctgg
      361 gcaacgaaga actggctgcc ctcaagttcc tgtgcttgga ccacatcccg cagaagaagc
      421 aggagtccat caatgatgtc ctggtgctat ttcagaggct gcaggaagag gggatgttgg
      481 aggaagacaa tttgtccttc ctgaaggagc tgcttttcca tatcagtcgg cgggatctgc
      541 tgagcagagt cctaaaaagc agcccagagg aaatggtgag ggagctgcag gttctgggca
      601 aagcccaggt ttctgcctac agggttatgc tctttaagct ctcagaagac atggacaagg
      661 aggatttgaa atcttttaag ttccttttga tcactgagat ccctaaatgt aaactgcaag
      721 acaactcgag cctgcttgat attttcgtag agatggagaa gaggactatc ctggcagaaa
      781 acaacttggt taccctaaaa tcaatctgtt tccgggtcaa caggagcttg ctgggaagga
      841 tcgacgatta cgaacgatca agcacagaga gaagaatgag cactgaagga ggggaagagc
      901 tgccagtttc tgttttggat gaggtgacca tcaaaatgca ggacatgtgg gactcgccag
      961 gagagcaaga gagtgagtca ctaaattcag acaatgttta ccaaatgaag agcaaacctc
     1021 gggggtactg tctgatcttc aacaataata atttcagcaa agcacgggag gacataccca
     1081 aactcagcaa catgcgggac agaaaaggaa ccaactatga tgaagaggct ctgagtaaga
     1141 cctttaagga gcttcatttt gagatcgtgt ccttcagtga ttgcacagca agtcaaatcc
     1201 atgaggttct agtatcctat caaagcaagg accacaaggg caaagactgc ttcatctgct
     1261 gcatcctatc acatggggac aagggcatcg tctacggaac ggatgggaag gaagcctcta
     1321 tctatgagct gacatcttac ttcactggct caaagtgccc ttccctggct ggaaaaccca
     1381 aaatcttttt tattcaagct tgtcaaggaa ataacttcca gaaagcggtg cctgtgcctg
     1441 atgagacagg cttagaacag gagcacgttt tagaagagga ttcatcatct tacaagaact
     1501 atatcccaga tgaggcagac tttctgctgg ggatggctac tgtgaaaaac tgtgtttcct
     1561 accgagatcc cacgcgtggg acctggtata tccagtcact ttgccagagc ctgagggaaa
     1621 gatgtcctcg aggtgaggat attctcagca tcctgactgg cgtgaactat gatgtgagca
     1681 ataaagacaa cccgaggaac atgggaaagc agatgccaca gcccatcttc acactacgga
     1741 agaagctctt cttccctcct aactgatgtg tgctctctac agttcacatg ggttatctgt
     1801 gcacttttgt gtgtcctaac tgatgtgtgc tctctacagt tcacatgggt tatctgtgca
     1861 cttttgtgtg aaggagagaa tcttatttat tttttttacc atttcttttg tttttgagtt
     1921 tacatttatg tcatttccgt tttctctctt caaatcttcc tatgtaatct tccagtttca
     1981 aatacatgac ctcttttgtc atcaattgtt gtatacgcat gcacacacgc gtgcatgcac
     2041 atacacacaa acttctaaat gtaatctacc cagtctttat actgttactt tttgcttttt
     2101 aaaaatggag taacctcggg gctggggatt tagctcagtg gtagagcgct tacctaggaa
     2161 gcgcaaggcc ctgggttcgg tccccagctc cgaaaaaaaa aaatggagta acctctggga
     2221 cttcctgtcc ctagaatagt tgggcaacat aaattgtatt ccattggttc acctttaatc
     2281 ccagcactcc ggaggcagag gcaagaggat ctctgaattc aaagccagcc tgctctacag
     2341 agcaagttct aagacagcca gggctacaca gagaaagctt gtcttaaaaa aaaaaataat
     2401 aatacttgaa gatgtgtgag taagaaagca agactggatc atggactggg acgagttaac
     2461 agagggagtg aatagcattg tctgcatgcg attctgggac ttaataaaag tattaaactt
     2521 c
//
LOCUS       NM_001107754            2753 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.
ACCESSION   NM_001107754 XM_001079281 XM_230377
VERSION     NM_001107754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Yang,P., Wang,Y., Ge,W., Jing,Y., Hu,H., Yin,J., Xue,M., Wang,Y.,
            Li,X., Li,X., Shi,Y., Tan,J., Li,Y. and Yan,S.
  TITLE     m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production
  JOURNAL   Free Radic Biol Med 209 (Pt 2), 342-354 (2023)
   PUBMED   37898386
  REMARK    GeneRIF: m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production.
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Wei,B., Su,Z., Yang,H., Feng,Y., Meng,C. and Liang,Z.
  TITLE     Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by
            alleviating pyroptosis in vitro and in vivo rat models
  JOURNAL   Biol Direct 18 (1), 23 (2023)
   PUBMED   37165439
  REMARK    GeneRIF: Inhibition of TRAF6 improves hyperlipidemic acute
            pancreatitis by alleviating pyroptosis in vitro and in vivo rat
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Xia,P., Marjan,M., Liu,Z., Zhou,W., Zhang,Q., Cheng,C., Zhao,M.,
            Tao,Y., Wang,Z. and Ye,Z.
  TITLE     Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner
  JOURNAL   Exp Neurol 357, 114197 (2022)
   PUBMED   35932799
  REMARK    GeneRIF: Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner.
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Zhang,T. and Ge,J.
  TITLE     Mechanism of CREB1 in cardiac function of rats with heart failure
            via regulating the microRNA-376a-3p/TRAF6 axis
  JOURNAL   Mamm Genome 33 (3), 490-501 (2022)
   PUBMED   35217880
  REMARK    GeneRIF: Mechanism of CREB1 in cardiac function of rats with heart
            failure via regulating the microRNA-376a-3p/TRAF6 axis.
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Wei,B., Wu,Q., Yang,X., Lai,C., Su,Z. and Liang,Z.
  TITLE     Effect of TRAF6 in acute pancreatitis-induced intestinal barrier
            injury via TLR4/NF-kappaB signal pathway
  JOURNAL   Tissue Cell 76, 101792 (2022)
   PUBMED   35405432
  REMARK    GeneRIF: Effect of TRAF6 in acute pancreatitis-induced intestinal
            barrier injury via TLR4/NF-kappaB signal pathway.
REFERENCE   6  (bases 1 to 2753)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   7  (bases 1 to 2753)
  AUTHORS   Lomaga,M.A., Henderson,J.T., Elia,A.J., Robertson,J., Noyce,R.S.,
            Yeh,W.C. and Mak,T.W.
  TITLE     Tumor necrosis factor receptor-associated factor 6 (TRAF6)
            deficiency results in exencephaly and is required for apoptosis
            within the developing CNS
  JOURNAL   J Neurosci 20 (19), 7384-7393 (2000)
   PUBMED   11007897
REFERENCE   8  (bases 1 to 2753)
  AUTHORS   Naito,A., Azuma,S., Tanaka,S., Miyazaki,T., Takaki,S., Takatsu,K.,
            Nakao,K., Nakamura,K., Katsuki,M., Yamamoto,T. and Inoue,J.
  TITLE     Severe osteopetrosis, defective interleukin-1 signalling and lymph
            node organogenesis in TRAF6-deficient mice
  JOURNAL   Genes Cells 4 (6), 353-362 (1999)
   PUBMED   10421844
REFERENCE   9  (bases 1 to 2753)
  AUTHORS   Lomaga,M.A., Yeh,W.C., Sarosi,I., Duncan,G.S., Furlonger,C., Ho,A.,
            Morony,S., Capparelli,C., Van,G., Kaufman,S., van der Heiden,A.,
            Itie,A., Wakeham,A., Khoo,W., Sasaki,T., Cao,Z., Penninger,J.M.,
            Paige,C.J., Lacey,D.L., Dunstan,C.R., Boyle,W.J., Goeddel,D.V. and
            Mak,T.W.
  TITLE     TRAF6 deficiency results in osteopetrosis and defective
            interleukin-1, CD40, and LPS signaling
  JOURNAL   Genes Dev 13 (8), 1015-1024 (1999)
   PUBMED   10215628
REFERENCE   10 (bases 1 to 2753)
  AUTHORS   Ninomiya-Tsuji,J., Kishimoto,K., Hiyama,A., Inoue,J., Cao,Z. and
            Matsumoto,K.
  TITLE     The kinase TAK1 can activate the NIK-I kappaB as well as the MAP
            kinase cascade in the IL-1 signalling pathway
  JOURNAL   Nature 398 (6724), 252-256 (1999)
   PUBMED   10094049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168921.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001107754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168921.1, SRR8487227.172149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..2753
                     /gene="Traf6"
                     /note="TNF receptor associated factor 6"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
     exon            1..168
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    146..148
                     /gene="Traf6"
                     /note="upstream in-frame stop codon"
     exon            169..486
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1783
                     /gene="Traf6"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase TRAF6; TNF
                     receptor-associated factor 6, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase TRAF6"
                     /codon_start=1
                     /product="TNF receptor-associated factor 6"
                     /protein_id="NP_001101224.1"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
                     /translation="MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGN
                     LSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAG
                     HKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALV
                     ICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYC
                     GTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQA
                     VHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMH
                     VSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGR
                     PGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVI
                     RQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVS
                     TRFDMGGLRKEGFQPRSTDAGV"
     misc_feature    191..1276
                     /gene="Traf6"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1);
                     Region: Interaction with TAX1BP1. /evidence=ECO:0000250"
     misc_feature    389..562
                     /gene="Traf6"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in tumor necrosis factor (TNF) receptor-associated
                     factor 6 (TRAF6) and similar proteins; Region:
                     mRING-HC-C3HC3D_TRAF6; cd16643"
                     /db_xref="CDD:438305"
     misc_feature    389..562
                     /gene="Traf6"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in tumor necrosis factor (TNF) receptor-associated
                     factor 6 (TRAF6) and similar proteins; Region:
                     mRING-HC-C3HC3D_TRAF6; cd16643"
                     /db_xref="CDD:438305"
     misc_feature    order(389..394,434..436,440..454,542..556)
                     /gene="Traf6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    order(389..394,434..436,440..454,542..556)
                     /gene="Traf6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    order(395..397,401..415,479..481,488..493,506..508)
                     /gene="Traf6"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    order(395..397,401..415,479..481,488..493,506..508)
                     /gene="Traf6"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    <584..847
                     /gene="Traf6"
                     /note="PRLI-interacting factor K; Provisional; Region:
                     PLN03086"
                     /db_xref="CDD:178635"
     misc_feature    <584..847
                     /gene="Traf6"
                     /note="PRLI-interacting factor K; Provisional; Region:
                     PLN03086"
                     /db_xref="CDD:178635"
     misc_feature    659..739
                     /gene="Traf6"
                     /note="TNF receptor-associated factor 6 zinc finger 2;
                     Region: TRAF6_Z2; pfam18048"
                     /db_xref="CDD:436235"
     misc_feature    659..739
                     /gene="Traf6"
                     /note="TNF receptor-associated factor 6 zinc finger 2;
                     Region: TRAF6_Z2; pfam18048"
                     /db_xref="CDD:436235"
     misc_feature    800..973
                     /gene="Traf6"
                     /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
                     /db_xref="CDD:280357"
     misc_feature    800..973
                     /gene="Traf6"
                     /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
                     /db_xref="CDD:280357"
     misc_feature    1265..1714
                     /gene="Traf6"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF6 subfamily, TRAF domain,
                     C-terminal MATH subdomain; composed of proteins with
                     similarity to human TRAF6, including the Drosophila
                     protein DTRAF2. TRAF molecules serve as adapter...;
                     Region: MATH_TRAF6; cd03776"
                     /db_xref="CDD:239745"
     misc_feature    1265..1714
                     /gene="Traf6"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF6 subfamily, TRAF domain,
                     C-terminal MATH subdomain; composed of proteins with
                     similarity to human TRAF6, including the Drosophila
                     protein DTRAF2. TRAF molecules serve as adapter...;
                     Region: MATH_TRAF6; cd03776"
                     /db_xref="CDD:239745"
     misc_feature    order(1274..1276,1280..1282,1364..1369,1463..1465,
                     1472..1474,1523..1525)
                     /gene="Traf6"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239745"
     misc_feature    order(1274..1276,1280..1282,1364..1369,1463..1465,
                     1472..1474,1523..1525)
                     /gene="Traf6"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239745"
     misc_feature    1277..1780
                     /gene="Traf6"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1);
                     Region: Interaction with TANK.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4K3"
     misc_feature    order(1388..1390,1442..1444,1580..1588,1616..1630)
                     /gene="Traf6"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239745"
     misc_feature    order(1388..1390,1442..1444,1580..1588,1616..1630)
                     /gene="Traf6"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239745"
     exon            487..637
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..796
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..868
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..946
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2707
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctggg gctgaggctc cggccgtcgg cggacgcagt agccgcggcc caggaaccgg
       61 gagtttggcg tcggagacac ttgatctcgg agtgctgcgt gtataggcgg cgcgtggcgg
      121 cccgggggag ctttctagtc ggttgtgaag cctctgcgtg tgcgatcgat tgactgacaa
      181 caaagctact atgagtctct taaactgtga aaacagctgt gcgtccagcc agtcttcaag
      241 cgactgctgt gctgccatgg ccaactcctg cagtgctgcc atgaaagatg acagtgtgag
      301 tggctgtgtc agcacgggga acctgtccag ctccttcatg gaggagatcc agggatatga
      361 tgtggagttt gacccacctt tggaaagcaa gtatgagtgc cccatctgct tgatggcttt
      421 acgggaagca gtgcaaacac catgtggcca caggttctgc aaagcctgca tcaccaagtc
      481 cataagggat gcaggtcaca agtgcccagt tgacaatgaa atactgctgg aaaatcaact
      541 gtttcctgac aattttgcaa agcgagagat tctttccctg acggtaaagt gtccaaataa
      601 aggctgtgtg caaaagatgg agctgagaca tctcgaggat catcaagtac attgtgaatt
      661 cgctctagtg atttgtcccc aatgccaacg ttttttccaa aagtgccaga ttaataaaca
      721 cattatcgag gattgtccca ggagacaggt ttcttgtgta aactgtgctg tgcccatgcc
      781 gtatgaagag aaagagatcc acgatcaaag ctgtcctctg gcaaatatca tctgtgaata
      841 ctgtggtaca atcctcataa gagaacagat gcctaatcat tatgatctag actgcccaac
      901 agctccagtc ccctgcacat tcagtgtgtt tggctgtcac gaaaagatgc agaggaatca
      961 cttggcacgg cacttgcaag agaacaccca gttgcacatg agactgttgg cccaggctgt
     1021 tcataatgtt aacctctctt tgcggccatg cgatgcctcc tctccatccc ggggatgtcg
     1081 tcctgaggac ccaaattatg aggaaacggt caaacagttg gaggggcgcc tagtaagaca
     1141 ggaccatcaa atccgggagc tgaccgccaa aatggaaacg cagagcatgc atgtgagcga
     1201 gctcaagcgg accattcgaa gcctcgagga caaagttgcc gagatggaag cacagcagtg
     1261 taatggcatt tacatttgga agattggcaa ctttgggatg cacttgaaat cccaagaaga
     1321 ggaaagacct gtggtcattc atagccctgg attctacaca ggcagacctg ggtacaagct
     1381 gtgcatgcgc ctgcacctcc agctaccgac ggctcagcgc tgtgcaaact acatttccct
     1441 ctttgtccac acaatgcaag gagagtatga cagccacctc ccctggccct tccagggtac
     1501 aatacgcctc acgatccttg atcagtctga agcagtaata aggcaaaacc acgaagaggt
     1561 catggatgct aagccagaac tgcttgcctt tcagcggccc accatcccac ggaaccccaa
     1621 aggttttggc tatgtgacat tcatgcacct ggaagcctta agacagggaa ccttcatcaa
     1681 ggatgatacg ttattagtgc gctgtgaagt ctctacccgc tttgacatgg ggggccttcg
     1741 gaaggagggg ttccagccac ggagtactga tgcaggcgtg tagcctccac ttacctgtgt
     1801 tcaaaaacta ggagccatat ggaaaaaccg tgccttccgc acctggtcca gtaaacaaac
     1861 ggtgggagag gtgtaaggcc agcagcagat gtcatcagcg aggtcacatt acacttctta
     1921 ccgttaacca atatctgggg caattcccat ggggacctcc gtgtcccctg tgtcttcaga
     1981 accttaacat ttgaagggcc agacgctcat caatttgtca gggaacctct tcactgtgct
     2041 tccatgggct tttttgtcca tgtactttac tgaaaaaaaa aaaggccaga attaatgtac
     2101 tggagctcaa tcgtttaata ctggtgcctt aaacacttaa agtgctttta gggcatgtat
     2161 taaacgtgag gatcaccatt gcctgtgctg ctgccagtgg aaaggttact gctctggtgt
     2221 tgagttctca tttagttgac ccctgtgaat ttcagaggct ttgaaccatg atccctggaa
     2281 agctgaagtt ctcatgtact ccctcctcca ttgaccaggg actggtttaa cccttactta
     2341 taaatagcac gaatgtattg tccattgaac accaagggtt tctcccctgc cttcattgtt
     2401 gaaatatgct ctaggcagca tcttcccggt ttgtaagact gtggtcatgt ggttgccaac
     2461 tgttcagtgt gactgtcatg taacctttct tgtctgttca gtatagcttg gtttccacag
     2521 cctgtcgcac atcttctgtt gcttgcaaac acaaaatcgc cagcctaaac aagtgatcag
     2581 ctcaccagcc attaaatggc atctcatgga tgatgacagc aattcttata gccaggaaac
     2641 ttcagccctc ttaactacct tccaatttag cttagttgat tgaaataaaa ctgatttcct
     2701 caaggggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
LOCUS       NM_001105720            1583 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus NFKB inhibitor alpha (Nfkbia), mRNA.
ACCESSION   NM_001105720 XM_001075778 XM_343065
VERSION     NM_001105720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Cui,L. and Ma,J.
  TITLE     NEDD4L Promotes IkappaBalpha Ubiquitination and Degradation in the
            Pathogenesis of Diabetic Retinopathy
  JOURNAL   Curr Eye Res 49 (1), 62-72 (2024)
   PUBMED   37768316
  REMARK    GeneRIF: NEDD4L Promotes IkappaBalpha Ubiquitination and
            Degradation in the Pathogenesis of Diabetic Retinopathy.
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Fan,Y., Wang,J., Feng,Z., Cao,K., Xu,H. and Liu,J.
  TITLE     Pinitol attenuates LPS-induced pneumonia in experimental animals:
            Possible role via inhibition of the TLR-4 and
            NF-kappaB/IkappaBalpha signaling cascade pathway
  JOURNAL   J Biochem Mol Toxicol 35 (1), e22622 (2021)
   PUBMED   32926510
  REMARK    GeneRIF: Pinitol attenuates LPS-induced pneumonia in experimental
            animals: Possible role via inhibition of the TLR-4 and
            NF-kappaB/IkappaBalpha signaling cascade pathway.
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Li,S., Jiang,L., Yang,Y., Cao,J., Zhang,Q., Zhang,J., Wang,R.,
            Deng,X. and Li,Y.
  TITLE     Siglec1 enhances inflammation through miR-1260-dependent
            degradation of IkappaBalpha in COPD
  JOURNAL   Exp Mol Pathol 113, 104398 (2020)
   PUBMED   32007531
  REMARK    GeneRIF: the present study demonstrated that Siglec1 exerts its
            proinflammatory effects through increasing miR-1260, leading to
            decreased expression of IkappaBalpha.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Liang,W.J., Yang,H.W., Liu,H.N., Qian,W. and Chen,X.L.
  TITLE     HMGB1 upregulates NF-kB by inhibiting IKB-alpha and associates with
            diabetic retinopathy
  JOURNAL   Life Sci 241, 117146 (2020)
   PUBMED   31816325
  REMARK    GeneRIF: High IKB-alpha expression is associated with diabetic
            retinopathy.
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Zabel,U., Henkel,T., Silva,M.S. and Baeuerle,P.A.
  TITLE     Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein
            present in the nucleus
  JOURNAL   EMBO J 12 (1), 201-211 (1993)
   PUBMED   7679069
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Ganchi,P.A., Sun,S.C., Greene,W.C. and Ballard,D.W.
  TITLE     I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B
            p65 and requires the transactivation domain to inhibit NF-kappa B
            p65 DNA binding
  JOURNAL   Mol Biol Cell 3 (12), 1339-1352 (1992)
   PUBMED   1493333
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Tewari,M., Dobrzanski,P., Mohn,K.L., Cressman,D.E., Hsu,J.C.,
            Bravo,R. and Taub,R.
  TITLE     Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that
            inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel
            kappa B site-binding complex
  JOURNAL   Mol Cell Biol 12 (6), 2898-2908 (1992)
   PUBMED   1588976
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Tewari,M., Mohn,K.L., Yue,F.E. and Taub,R.
  TITLE     Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with
            related proteins containing notch-like repeats [corrected]
  JOURNAL   Nucleic Acids Res 20 (3), 607 (1992)
   PUBMED   1741294
  REMARK    Erratum:[Nucleic Acids Res 1992 Jun 11;20(11):2931]
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Baeuerle,P.A. and Baltimore,D.
  TITLE     I kappa B: a specific inhibitor of the NF-kappa B transcription
            factor
  JOURNAL   Science 242 (4878), 540-546 (1988)
   PUBMED   3140380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB793714.1, CB316505.1, BF417507.1, CB324027.1 and CA509173.1.
            
            On Nov 15, 2007 this sequence version replaced NM_001105720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234262.1, BC166886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               CB793714.1         28-403
            377-754             CB316505.1         331-708
            755-1137            BF417507.1         7-389               c
            1138-1316           CB324027.1         267-445             c
            1317-1583           CA509173.1         1-267               c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1583
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="NFKB inhibitor alpha"
                     /db_xref="GeneID:25493"
                     /db_xref="RGD:3171"
     exon            1..346
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    60..62
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="upstream in-frame stop codon"
     CDS             120..1064
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ikB-alpha; ikappaBalpha; I-kappa-B-alpha; Inhibitor
                     of nuclear factor of kappa light chain gene enhancer in
                     B-cells, alpha; nuclear factor of kappa light chain gene
                     enhancer in B-cells inhibitor, alpha; nuclear factor of
                     kappa light polypeptide gene enhancer in B-cells
                     inhibitor, alpha"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor alpha"
                     /protein_id="NP_001099190.2"
                     /db_xref="GeneID:25493"
                     /db_xref="RGD:3171"
                     /translation="MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQ
                     MVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLA
                     FLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASV
                     AVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGR
                     TALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLEN
                     LQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL"
     misc_feature    120..236
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    207..227
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: Destruction motif.
                     /evidence=ECO:0000250|UniProtKB:P25963"
     misc_feature    213..215
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphoserine, by IKKA and IKKB.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    219..>887
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    219..>887
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    225..227
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphoserine, by IKKA, IKKB, IKKE and TBK1.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    243..245
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    252..281
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P25963"
     misc_feature    336..443
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    336..443
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    447..542
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    447..542
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    447..536
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: ANK 1"
     misc_feature    447..479
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: Nuclear import signal.
                     /evidence=ECO:0000250|UniProtKB:P25963"
     misc_feature    order(546..548,552..554,564..569,576..584,588..593,
                     603..605,612..614,657..659,663..665,669..671,681..686,
                     693..701,705..710,720..722,729..731,756..758,765..767,
                     771..773,783..788,795..803,807..812,822..824,831..833)
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(546..548,552..554,564..569,576..584,588..593,
                     603..605,612..614,657..659,663..665,669..671,681..686,
                     693..701,705..710,720..722,729..731,756..758,765..767,
                     771..773,783..788,795..803,807..812,822..824,831..833)
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    546..659
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    546..659
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    546..635
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: ANK 2"
     misc_feature    663..758
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    663..758
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    663..752
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: ANK 3"
     misc_feature    747..749
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); hydroxylation site"
     misc_feature    765..857
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    765..857
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    765..854
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63746.1);
                     Region: ANK 4"
     misc_feature    849..851
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); hydroxylation site"
     misc_feature    966..968
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    981..983
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    990..992
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphothreonine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    996..998
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     misc_feature    1005..1007
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P25963; propagated from
                     UniProtKB/Swiss-Prot (Q63746.1); phosphorylation site"
     exon            347..455
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..666
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..755
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1016
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1566
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaatcccct gccagcgttt atagggcgcc gaggcggcgc tgccgagccc acaacagtct
       61 gaactcgcca cccaactgcc agcagcctgc accctgcacc cgctcagctc cgcacagcca
      121 tgtttcagcc agctgggcac ggccaggact gggccatgga gggcccgcgg gacggcctca
      181 agaaggagcg gttggtggac gaccgccacg acagcggctt ggactccatg aaggacgagg
      241 attacgagca gatggtgaag gagctgcggg agatccgcct gcagccgcag gaggcgcctc
      301 tggctgccga gccctggaag caacagctca cggaggacgg agactcgttc ctgcacttgg
      361 caatcatcca tgaagagaag acactgacca tggaagtgat tggtcaggtg aagggagacc
      421 tggccttcct caacttccag aacaacctgc agcagactcc actccacttg gctgtgatca
      481 ccaaccagcc aggaattgct gaggcacttc tgaaagctgg ctgtgatcct gagctccgag
      541 actttcgagg aaatacccct ctccatcttg cctgtgagca gggctgcctg gccagtgtag
      601 cagtcttgac tcagacctgt acgccccagc atctccactc cgtcctgcag gccaccaact
      661 acaacggcca cacgtgtcta cacttagcct ctatccatgg ctacctgggc atcgtggagc
      721 acttggtgac tttgggtgct gatgtcaacg ctcaggagcc ctgtaatggc cggacagccc
      781 tccaccttgc agtggacctg cagaatcctg acctggtctc gctcctgttg aagtgtgggg
      841 ctgatgtcaa cagagtaacc taccagggct actcccccta ccagcttacg tggggccgcc
      901 caagtacccg gatacagcag cagctgggcc agctgaccct ggaaaatctt cagacgctgc
      961 ccgagagtga ggatgaggag agctatgaca cggagtcaga attcacggaa gatgagttgc
     1021 cctacgatga ctgtgtgttt ggaggccagc gtctgacgtt ataagaggaa agtggccaaa
     1081 ggaacgtgga cttgtatatt tgtacaaata gagttttatt tttctaaaaa aaaaaaagaa
     1141 aaagaaaaaa aaataagaaa gggtatactt agcaccacag cacacagcgc ctagccccga
     1201 gcattctatt gtggtgattc agctgttgtt cttgtgaaat ttggggaaac agatcattga
     1261 aattcaaagg aaatgtctcc taaggttcat gtttgtggga tttttttttt ttttttgagg
     1321 tgattttcca gaatctgata aaaggaccac attttattta ttgtgctttt ggttgaaccg
     1381 ccatagactg tagctgaccc cagtgtgccc tctcacgtaa gaaccaggtg ttcagtggta
     1441 tgtgcttaag tcatccccag ctgagatttg taccactttc ttgtaaatgt tgtatatggt
     1501 gtattttgtt ggtaattatt ttggtacttc taagatgtat atttattaaa cagattttta
     1561 cagacaaaaa aaaaaaaaaa aaa
//
LOCUS       NM_019378               5666 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus SRC kinase signaling inhibitor 1 (Srcin1),
            transcript variant 2, mRNA.
ACCESSION   NM_019378
VERSION     NM_019378.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5666)
  AUTHORS   Calipari,E.S., Godino,A., Salery,M., Damez-Werno,D.M., Cahill,M.E.,
            Werner,C.T., Gancarz,A.M., Peck,E.G., Jlayer,Z., Rabkin,J.,
            Landry,J.A., Smith,A.C.W., Defilippi,P., Kenny,P.J., Hurd,Y.L.,
            Neve,R.L., Dietz,D.M. and Nestler,E.J.
  TITLE     Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation
            Mediate Structural and Behavioral Adaptations During Withdrawal
            From Cocaine Self-Administration
  JOURNAL   J Neurosci 39 (29), 5634-5646 (2019)
   PUBMED   31092585
REFERENCE   2  (bases 1 to 5666)
  AUTHORS   Wang,W., Zhu,X., Du,X., Xu,A., Yuan,X., Zhan,Y., Liu,M. and Wang,S.
  TITLE     MiR-150 promotes angiogensis and proliferation of endothelial
            progenitor cells in deep venous thrombosis by targeting SRCIN1
  JOURNAL   Microvasc Res 123, 35-41 (2019)
   PUBMED   30315850
  REMARK    GeneRIF: Upregulation of miR-150 promoted angiogenesis and
            proliferation of endothelial progenitor cells by targeting SRCIN1
            in vitro and thrombus resolution in vivo.
REFERENCE   3  (bases 1 to 5666)
  AUTHORS   Li,M.Y., Miao,W.Y., Wu,Q.Z., He,S.J., Yan,G., Yang,Y., Liu,J.J.,
            Taketo,M.M. and Yu,X.
  TITLE     A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes
            in Stabilizing Spines and Functional Synapses in the Neocortex
  JOURNAL   Neuron 94 (6), 1155-1172 (2017)
   PUBMED   28641114
  REMARK    GeneRIF: Study demonstrates a critical role of presynaptic
            cadherin/catenin/p140Cap cell adhesion complexes in stabilizing
            functional synapses and spines in the developing neocortex.
REFERENCE   4  (bases 1 to 5666)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   5  (bases 1 to 5666)
  AUTHORS   Repetto,D., Camera,P., Melani,R., Morello,N., Russo,I.,
            Calcagno,E., Tomasoni,R., Bianchi,F., Berto,G., Giustetto,M.,
            Berardi,N., Pizzorusso,T., Matteoli,M., Di Stefano,P., Missler,M.,
            Turco,E., Di Cunto,F. and Defilippi,P.
  TITLE     p140Cap regulates memory and synaptic plasticity through
            Src-mediated and citron-N-mediated actin reorganization
  JOURNAL   J Neurosci 34 (4), 1542-1553 (2014)
   PUBMED   24453341
  REMARK    GeneRIF: we here demonstrate that p140Cap is a key element for both
            learning and synaptic plasticity
REFERENCE   6  (bases 1 to 5666)
  AUTHORS   Di Stefano,P., Damiano,L., Cabodi,S., Aramu,S., Tordella,L.,
            Praduroux,A., Piva,R., Cavallo,F., Forni,G., Silengo,L., Tarone,G.,
            Turco,E. and Defilippi,P.
  TITLE     p140Cap protein suppresses tumour cell properties, regulating Csk
            and Src kinase activity
  JOURNAL   EMBO J 26 (12), 2843-2855 (2007)
   PUBMED   17525734
REFERENCE   7  (bases 1 to 5666)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 5666)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   9  (bases 1 to 5666)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   10 (bases 1 to 5666)
  AUTHORS   Chin,L.S., Nugent,R.D., Raynor,M.C., Vavalle,J.P. and Li,L.
  TITLE     SNIP, a novel SNAP-25-interacting protein implicated in regulated
            exocytosis
  JOURNAL   J Biol Chem 275 (2), 1191-1200 (2000)
   PUBMED   10625663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2024 this sequence version replaced NM_019378.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000010.1  83064930-83065086   c
            158-459             JAXUCZ010000010.1  83042607-83042908   c
            460-483             JAXUCZ010000010.1  83033243-83033266   c
            484-679             JAXUCZ010000010.1  83027327-83027522   c
            680-878             JAXUCZ010000010.1  83026569-83026767   c
            879-972             JAXUCZ010000010.1  83025923-83026016   c
            973-1832            JAXUCZ010000010.1  83024668-83025527   c
            1833-1925           JAXUCZ010000010.1  83024142-83024234   c
            1926-1969           JAXUCZ010000010.1  83023875-83023918   c
            1970-2160           JAXUCZ010000010.1  83023438-83023628   c
            2161-2336           JAXUCZ010000010.1  83022133-83022308   c
            2337-2467           JAXUCZ010000010.1  83017044-83017174   c
            2468-2615           JAXUCZ010000010.1  83016795-83016942   c
            2616-2862           JAXUCZ010000010.1  83016285-83016531   c
            2863-3097           JAXUCZ010000010.1  83015612-83015846   c
            3098-3252           JAXUCZ010000010.1  83013471-83013625   c
            3253-3405           JAXUCZ010000010.1  83013106-83013258   c
            3406-5666           JAXUCZ010000010.1  83006588-83008848   c
FEATURES             Location/Qualifiers
     source          1..5666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..5666
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
     exon            1..157
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3627
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="isoform 2 is encoded by transcript variant 2;
                     p130Cas-associated protein; SNAP25-interacting protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1 isoform 2"
                     /protein_id="NP_062251.1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
                     /translation="MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPE
                     RSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEAL
                     SGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGA
                     QPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVL
                     FLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFY
                     ELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSP
                     ASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPT
                     SQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAG
                     DPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSS
                     PQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGA
                     STAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRG
                     SEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRL
                     QMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQED
                     PLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKAL
                     VLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTL
                     AQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEG
                     TPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQ
                     AELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYR
                     TEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVK
                     LRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAA
                     QGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS"
     misc_feature    88..273
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    172..174
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    187..189
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    268..270
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    289..291
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    292..294
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    325..327
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    565..567
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    631..633
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    643..645
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    673..675
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    688..>927
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    688..>927
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    811..813
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    859..861
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    988..1278
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1030..1032
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1057..1059
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1108..1110
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1123..1125
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1144..1146
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1165..1167
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1222..1224
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1228..1230
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1324..1326
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1534..2061
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1612..1614
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1621..1623
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1633..1635
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1636..1638
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); methylation site"
     misc_feature    1642..1644
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1672..1674
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1678..1680
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1684..1686
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1699..1701
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1924..1926
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    1996..1998
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2005..2007
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2044..2046
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2074..2226
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Interaction with SNAP25.
                     /evidence=ECO:0000269|PubMed:10625663"
     misc_feature    <2191..2655
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <2191..2655
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    2665..2667
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2704..2880
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2731..2733
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2785..2787
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0H9; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    2980..3228
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3094..3096
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3262..3264
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3313..3315
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QWI6; propagated from
                     UniProtKB/Swiss-Prot (Q9QXY2.1); phosphorylation site"
     misc_feature    3454..3522
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXY2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            158..459
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            460..483
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            484..679
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            680..878
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            879..972
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1832
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1925
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1969
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2160
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2336
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2467
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2615
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2862
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3097
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3252
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3405
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..5666
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggtgcg cgcccccagc cccacgcctc cccatgcagc cctggcagtg cctccggcgc
       61 tttgccctgg cctggtggga gaggaccgcc gagggtcgcg cccgttctcc cagggaggag
      121 gttggaccga gggaccctgg gggccgaggg gagccagatc cggagcggag cagccccccc
      181 atgctgtctg ccgacgatgc cgaatatcct cgggagtacc ggaccctggg gggtgggggc
      241 agcgggggca gcgggggccg gcgcttctcc aacgtggggc tggtgcacac ctccgagcgg
      301 cggcacacgg tgatcgctgc ccagagcctg gaggccctca gcgggctcca gaaggccgat
      361 gctgaccgca agcgagatgc gtttatggac cacctgaaga gcaagtaccc ccagcatgcc
      421 ctggcccttc gaggtcagca ggacaggatg agagagcagc aaccaaacta ctggagtttc
      481 aagacccgca gctcgcgcca tactcaggga gcccagccag ggctggcaga ccaggcagcc
      541 aagctgtcct acgcctcggc tgagtcgctg gagacaatgt ccgaggccga gctgcccctg
      601 ggcttcagca ggatgaatcg cttccgacag agcttgcctc tctcccgctc tgccagccag
      661 accaagctgc gctcaccagg agtcctgttc ctgcagttcg gggaggagac gcgacgtgta
      721 cacatcacgc atgaggtcag cagcctggac acgctgcacg cactcatcgc gcacatgttc
      781 ccgcagaagc tcaccatggg catgcttaag tcgcccaaca ccgccatcct catcaaggac
      841 gaggctcgca acgtcttcta cgagctggaa gacgtccggg atatccagga ccggagtatc
      901 atcaagatct ataggaagga gccactgtat gccgcttttc ctggctcgca cctcaccaac
      961 ggtgacctcc ggagagagat ggtttacgca tcgcgggagt cgtcgcccac gcggcgcctc
     1021 aacaacctgt cgcccgcatc gcacctagca tctagctccc cgcctccagg gctgccatcc
     1081 gggctgcctt cgggactgcc atcgggctcg ccctcgcgtt cacgcctctc gtatgctggg
     1141 ggccggccgc cctcttacgc cggcagcccg gtacaccacg cggctgagcg actgggaggc
     1201 gccccgacca gccagggcgt gagccccagc cccagcgcca tcctggagcg gcgcgacgtg
     1261 aagccagatg aggatctggc gggcaaggcg ggcggcatgg tgctggtgaa gggcgagggc
     1321 ctctatgccg atccctacgg gctgctgcac gagggccgct tgagcctggc cgccgcagca
     1381 ggagacccgt tcgcataccc gggcgcgggc ggcttgtaca agcggggttc tgtgcgctcg
     1441 ctcagcacct actcggccgc tgcgctgcag tccgacctgg aggactcgct gtacaaggcg
     1501 ggcgccggcg gcccgctcta cggagacggc tatggcttcc gtctgccgcc ttcgtccccg
     1561 cagaaactag ccgacgtctc agcgccctcc gggggacctc cgccaccgca cagcccctac
     1621 tctgggccgc ccagccgcgg ctcgccggtg cgccagtcgt tccgtaaaga ttctggttcc
     1681 tcgtcggtct ttgctgagag tcctggaggc aaagcccgca gcaccggggc ttccacggcc
     1741 ggagcaccac cttctgaact cttccctgga cctggagagc gctccctcgt agggttcggg
     1801 ccgccggtgc cagccaagga cacagagacc agggagcgta tggaggccat ggagaagcag
     1861 attgccagcc tcactgggct agtacagagt gctttactgc gaggctcgga gccggagacc
     1921 ccaagtgaga agattgaagg ctccaatgga gcagccaccc cctcagcacc agtgtgtggg
     1981 tcaggcagta ggagtagcgg ggccactcca gtgtcgggcc ctcccccacc cgcggtcagc
     2041 agcacccctg cagggcagcc cactgctgtc agccggctgc aaatgcagat gcatctgcgt
     2101 ggcctacaga acagcgctag cgacctgcgt ggccagcttc agcagttgcg gaagctccag
     2161 ctccagaacc aggagtcggt gcgcgcgctg ctgaagcgca ccgaggcgga gctgagcatg
     2221 cgcgtgtcgg aggcggcgcg gcggcaggag gacccgctgc agcggcagcg caccctggtg
     2281 gaagaggagc gtttgcgtta cctcaacgac gaggagctca ttacacagca gctcaatgac
     2341 ctggagaagt cagtggagaa gatccagagg gatgtggccc ataaccaccg gctggtgcct
     2401 ggtcctgagt tggaagagaa ggctctggtg ctgaaacagc ttggggagac gctgacggaa
     2461 ctcaaggctc atttcccagg cctgcagagt aagatgcggg tagtgctgcg tgtagaggtg
     2521 gaggcagtca agtttctgaa ggaggaacct caacgcctcg acgggcttct caagcgctgc
     2581 cgggtggtca ctgacacgct ggcccagatc cgaaggcaag tggatgaggg tgtgtggcct
     2641 ccccccaaca atctcctgaa ccagtccccc aagaaggtgg cagccgaaac agacttcagc
     2701 aaaggcctgg attttgagat accacccccg agtcctccac tgaatctcca cgagctgagc
     2761 gggcctgcgg aaggcacccc gcttacccca aaaagcggca accctaccaa aggcctggat
     2821 gctccgagca agagaaacat ggacaaagct gtgtctgtcg aggctgcaga gagagactgg
     2881 gaagagaagc gggccgccct gacccagtac agcgccaagg acatcaaccg gctgctggag
     2941 gaaacccaag ctgagctgct caaggctatc cccgacctgg actgtgccag caagacccac
     3001 ccaggcccta ctcccactcc agaccacaag ccccctaagg caccccatgg tcagaaggct
     3061 gctccccgga cagagcccag tgggagaaga ggatcagatg agctcacagt gccccgatac
     3121 cgcacagaga agccctccaa gtcgcccccg ccaccccctc cccgccggag cttcccttcc
     3181 tcgcacggcc tgaccaccac tcgcaccgga gaagtggtgg tcaccagtaa gaaagactca
     3241 gtcttcatca agaaggctga atctgaggag ctggagatcc agaagcctca ggtgaagctg
     3301 cgtcgcgctg tgtctgaggt ggtccgcccc gcgtccacac cgcccattat ggcctcggcc
     3361 atcaaggatg aagacgatga ggaacgcatc attgctgagc tggagagtgg tggtggcagt
     3421 gtgccaccca tgaaggtggt gactcccgga gcctctcggc tgaaggcggc ccagggtcca
     3481 gcaggcagcc ctgataaagg caaacacggc aagcaacgaa cggaatacat gaggatccag
     3541 gcccagcagc aggtgagggt gggataccag gcacccaggc ccctggaggg ctgtacacca
     3601 aggctctgct atatgccgct gtcttaagat agttctgatc ttctgattcc ctccatttct
     3661 ttcctcatcg cgggcctagt gctttggatc tggtatatag acacgagtct ctggactcac
     3721 agccagtctc ctgctcagcg ttagaggagc ctcaccccct tccttgcaca gggcctgtcc
     3781 ctatacagat tcacttcctg ccccagtggt tgggtccctt ctaaagcctg ccacacagcc
     3841 atcttacctc tgcccctgtg cagcgccccc cccccccccg ctttgcacag tttttcaact
     3901 ctcagttcag gaagaagctt tcagcaggca catttcggtg acgggtcggg gcgcacagcc
     3961 tacaacgccc atccagtgtg ctcagaatcc cgcagacgta acaacccgct tggatttgta
     4021 ggtttggagt tgacagaatt cacccatgct acttagagcc ctggagcctg ctcgtgagat
     4081 ctgccgggtc agagtaaagg agggccctgg tggtaacagc tattgagagc ccctcagtgc
     4141 tcatgctcag ttcaaaacct ctcctgagga gctcttagtg ccaggcccgc ttggggtccc
     4201 aggtaggcct tgttctgtcc agatagaaat ccaaagttct ggcgtattag gctagggatg
     4261 gcccgggatg gccatgaggg tcagctcata gcaggagaga gactccccag tcctgtagag
     4321 cgaatgacat tagagctaag acggagactt agcttcctta aaaccccttc caccgtaggc
     4381 cacagatagc cctgggcaag accttgtcta ctttctggct gctagggaga caagcattca
     4441 attgcccccc agcttttctt cctcagcccc cacttgttcg tggtccccag actcacccag
     4501 tgagacccat tcccccagtt cttttctgtg actgaaatgg gtaaggactt cttgtctggg
     4561 atgctggtgg tgggggtccc ctcatttcac gcccagaaaa ccagctgata gccaatgggg
     4621 tatttactcg tgtcaggcac atccggtgcc tgtttcacag cagtctgagg tagaacaggt
     4681 gaagaggctg agatgggatg ggaatctgac acctgacaga cctctatcat gcatatgtct
     4741 gcttctgccc aggcaggacc ccttcctatc ccccacccac cactgcagct acacctccct
     4801 gtccttgccc tgtcttgtaa ctccctcaaa atccaggccc tgttacctgc tgtcctgtgg
     4861 gtcagctcca tacattccag gcctgaccct tctcctcagc cttccctgct tcctacatgg
     4921 catagcaagg cctccaagga ccatgctagc tctttcctct tcctcctggg taccgtggct
     4981 gtttagaaaa ttccccatat ctatgccgct gtgcagccct tccctggctt ggtaaacccc
     5041 ctgctctcac atcagcccct ccccatcctg ggtccattct gaacctcgaa agctcatatg
     5101 aaactttgag ctagacagag catcttcttg tacgcccatg gtccaagaat ggtcttctgt
     5161 ggaggaaagt ctactggaga cctctgtcct cccgcctcag gtccttggat gctgaggtag
     5221 aatccaaggt tccacagcct cgggaaggag gaataggaat ctatgagaga ggggaagggg
     5281 acacccaccc agccaccctg ccagccagat cgggtgtcac agccaggtca ccacatacct
     5341 ggcctgcctg gccactgagt gaactcacct ccagcccctc tctgtcagtg gtcccagctc
     5401 ttccatcgtc acagagtggc cccaggtgta ggcccctaag gaagcaccac ccagccccca
     5461 aaccccacag ctcctggact ccactgggtc cttcctgccc ctcccaaccc aggatggacc
     5521 ccattcccac cccattgtcc tttgccgtcc actcctctca catgtgctgt ggccagggtc
     5581 tctctgcttt ctgacaaagt gagacacgct tcttaggaaa aaaaaatttt tttttaaata
     5641 aagaaaacaa taaaggaatc gatgtg
//
LOCUS       NM_012854                682 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus interleukin 10 (Il10), mRNA.
ACCESSION   NM_012854
VERSION     NM_012854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Ren,Z.Y., Wang,J., Xu,F., Gao,Y., He,Q., Pan,B. and Lyu,S.C.
  TITLE     IL-10 dependent modulatory effect of regulatory B10 cells on local
            scar formation following Roux-en-Y choledochojejunostomy in a novel
            rat model
  JOURNAL   Int Immunopharmacol 126, 111309 (2024)
   PUBMED   38048666
  REMARK    GeneRIF: IL-10 dependent modulatory effect of regulatory B10 cells
            on local scar formation following Roux-en-Y choledochojejunostomy
            in a novel rat model.
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Yang,L., Cao,J., Du,Y., Zhang,X., Hong,W., Peng,B., Wu,J., Weng,Q.,
            Wang,J. and Gao,J.
  TITLE     Initial IL-10 production dominates the therapy of mesenchymal stem
            cell scaffold in spinal cord injury
  JOURNAL   Theranostics 14 (2), 879-891 (2024)
   PUBMED   38169599
  REMARK    GeneRIF: Initial IL-10 production dominates the therapy of
            mesenchymal stem cell scaffold in spinal cord injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Kosyreva,A.M., Dzhalilova,D.S., Tsvetkov,I.S., Makarova,M.A. and
            Makarova,O.V.
  TITLE     Ex Vivo Production of IL-1beta and IL-10 by Activated Blood Cells
            of Wistar Rats with Different Resistance to Hypoxia after Systemic
            Inflammatory Response Syndrome
  JOURNAL   Bull Exp Biol Med 176 (2), 290-296 (2023)
   PUBMED   38194074
  REMARK    GeneRIF: Ex Vivo Production of IL-1beta and IL-10 by Activated
            Blood Cells of Wistar Rats with Different Resistance to Hypoxia
            after Systemic Inflammatory Response Syndrome.
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Changaei,M., Javidan,M., Ramezani Tehrani,F., Mosaffa,N.,
            Noroozzadeh,M., Hosseinzadeh,R. and Rajaei,S.
  TITLE     Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo
            implantation site of rat model with prenatal androgen-induced
            polycystic ovary syndrome
  JOURNAL   Am J Reprod Immunol 90 (1), e13702 (2023)
   PUBMED   37062956
  REMARK    GeneRIF: Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in
            the embryo implantation site of rat model with prenatal
            androgen-induced polycystic ovary syndrome.
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Huynh,T., Reed,C., Blackwell,Z., Phelps,P., Herrera,L.C.P.,
            Almodovar,J., Zaharoff,D.A. and Wolchok,J.
  TITLE     Local IL-10 delivery modulates the immune response and enhances
            repair of volumetric muscle loss muscle injury
  JOURNAL   Sci Rep 13 (1), 1983 (2023)
   PUBMED   36737628
  REMARK    GeneRIF: Local IL-10 delivery modulates the immune response and
            enhances repair of volumetric muscle loss muscle injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Berg,D.J., Kuhn,R., Rajewsky,K., Muller,W., Menon,S., Davidson,N.,
            Grunig,G. and Rennick,D.
  TITLE     Interleukin-10 is a central regulator of the response to LPS in
            murine models of endotoxic shock and the Shwartzman reaction but
            not endotoxin tolerance
  JOURNAL   J Clin Invest 96 (5), 2339-2347 (1995)
   PUBMED   7593621
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   8  (bases 1 to 682)
  AUTHORS   Goodman,R.E., Oblak,J. and Bell,R.G.
  TITLE     Synthesis and characterization of rat interleukin-10 (IL-10) cDNA
            clones from the RNA of cultured OX8- OX22- thoracic duct T cells
  JOURNAL   Biochem Biophys Res Commun 189 (1), 1-7 (1992)
   PUBMED   1280414
REFERENCE   9  (bases 1 to 682)
  AUTHORS   de Waal Malefyt,R., Abrams,J., Bennett,B., Figdor,C.G. and de
            Vries,J.E.
  TITLE     Interleukin 10(IL-10) inhibits cytokine synthesis by human
            monocytes: an autoregulatory role of IL-10 produced by monocytes
  JOURNAL   J Exp Med 174 (5), 1209-1220 (1991)
   PUBMED   1940799
REFERENCE   10 (bases 1 to 682)
  AUTHORS   Vieira,P., de Waal-Malefyt,R., Dang,M.N., Johnson,K.E.,
            Kastelein,R., Fiorentino,D.F., deVries,J.E., Roncarolo,M.G.,
            Mosmann,T.R. and Moore,K.W.
  TITLE     Isolation and expression of human cytokine synthesis inhibitory
            factor cDNA clones: homology to Epstein-Barr virus open reading
            frame BCRFI
  JOURNAL   Proc Natl Acad Sci U S A 88 (4), 1172-1176 (1991)
   PUBMED   1847510
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L02926.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02926.1, X60675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="AO"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..682
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="interleukin 10"
                     /db_xref="GeneID:25325"
                     /db_xref="RGD:2886"
     exon            1..166
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..538
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="CSIF; IL-10; cytokine synthesis inhibitory factor;
                     interferon 2a"
                     /codon_start=1
                     /product="interleukin-10 precursor"
                     /protein_id="NP_036986.2"
                     /db_xref="GeneID:25325"
                     /db_xref="RGD:2886"
                     /translation="MPGSALLCCLLLLAGVKTSKGHSIRGDNNCTHFPVSQTHMLREL
                     RAAFSQVKTFFQKKDQLDNILLTDSLLQDFKGYLGCQALSEMIKFYLVEVMPQAENHG
                     PEIKEHLNSLGEKLKTLWIQLRRCHRFLPCENKSKAVEQVKNDFNKLQDKGVYKAMNE
                     FDIFINCIEAYVTLKMKN"
     sig_peptide     2..55
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29456.1)"
     misc_feature    41..523
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="Interleukin 10; Region: IL10; pfam00726"
                     /db_xref="CDD:334228"
     misc_feature    41..523
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="Interleukin 10; Region: IL10; pfam00726"
                     /db_xref="CDD:334228"
     mat_peptide     56..535
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /product="Interleukin-10. /id=PRO_0000015372"
                     /note="propagated from UniProtKB/Swiss-Prot (P29456.1)"
     misc_feature    86..88
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29456.1); glycosylation site"
     misc_feature    401..403
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P29456.1); glycosylation site"
     exon            167..226
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            227..379
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            380..445
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            446..682
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgcctggc tcagcactgc tatgttgcct gctcttactg gctggagtga agaccagcaa
       61 aggccattcc atccggggtg acaataactg cacccacttc ccagtcagcc agacccacat
      121 gctccgagag ctgagggctg ccttcagtca agtgaagact ttctttcaaa agaaggacca
      181 gctggacaac atactgctga cagattcctt actgcaggac tttaagggtt acttgggttg
      241 ccaagccttg tcagaaatga tcaagtttta cctggtagaa gtgatgcccc aggcagagaa
      301 ccatggccca gaaatcaagg agcatttgaa ttccctggga gagaagctga agaccctctg
      361 gatacagctg cgacgctgtc atcgatttct cccctgtgag aataaaagca aggcagtgga
      421 gcaggtgaag aatgatttta ataagctcca agacaaaggt gtctacaagg ccatgaatga
      481 gtttgacatc ttcatcaact gcatagaagc ctacgtgaca ctcaaaatga aaaattgaac
      541 cacccggcat ctactggact gcaggacata aatagagctt ctaaatctga tccagagatc
      601 ttagctaacg ggagcaactc cttggaaaac ctcgtttgta cctctctcca aaatatttat
      661 tacctctgat acctcagttc cc
//
LOCUS       NM_001287577            2673 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein alpha (Cebpa),
            transcript variant 1, mRNA.
ACCESSION   NM_001287577
VERSION     NM_001287577.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Wu,K., Huang,S., Zheng,F. and Liu,Y.
  TITLE     The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway
  JOURNAL   Acta Diabetol 60 (11), 1491-1503 (2023)
   PUBMED   37392202
  REMARK    GeneRIF: The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Xu,Z., Yao,X., Zhao,Y. and Yao,B.
  TITLE     C/EBPalpha involvement in microglial polarization via HDAC1/STAT3
            pathway aggravated sevoflurane-induced cognitive impairment in aged
            rats
  JOURNAL   PeerJ 11, e15466 (2023)
   PUBMED   37361037
  REMARK    GeneRIF: C/EBPalpha involvement in microglial polarization via
            HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive
            impairment in aged rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Lu,H., Chen,Y., Chen,Y., Huang,L. and Chen,L.
  TITLE     C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates
            Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of
            Vascular Smooth Muscle Cells in Aortic Dissection
  JOURNAL   J Immunol Res 2022, 7465353 (2022)
   PUBMED   36132983
  REMARK    GeneRIF: C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A
            Regulates Autophagy, Matrix Metalloproteinase Expression, and
            Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Duan,P., Wang,H., Yi,X., Zhang,H., Chen,H. and Pan,Z.
  TITLE     C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells
            and steroid-induced avascular necrosis of the femoral head by
            targeting the PPARgamma signalling pathway
  JOURNAL   Stem Cell Res Ther 13 (1), 342 (2022)
   PUBMED   35883192
  REMARK    GeneRIF: C/EBPalpha regulates the fate of bone marrow mesenchymal
            stem cells and steroid-induced avascular necrosis of the femoral
            head by targeting the PPARgamma signalling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Muller,C., Bremer,A., Schreiber,S., Eichwald,S. and Calkhoven,C.F.
  TITLE     Nucleolar retention of a translational C/EBPalpha isoform
            stimulates rDNA transcription and cell size
  JOURNAL   EMBO J 29 (5), 897-909 (2010)
   PUBMED   20075868
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Samuelsson,L., Stromberg,K., Vikman,K., Bjursell,G. and Enerback,S.
  TITLE     The CCAAT/enhancer binding protein and its role in adipocyte
            differentiation: evidence for direct involvement in terminal
            adipocyte development
  JOURNAL   EMBO J 10 (12), 3787-3793 (1991)
   PUBMED   1935900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain and recognizes the
            CCAAT motif in the promoters of target genes. The encoded protein
            functions in homodimers and also heterodimers with
            CCAAT/enhancer-binding proteins beta and gamma. Activity of this
            protein can modulate the expression of genes involved in cell cycle
            regulation as well as in body weight homeostasis. The use of
            alternative in-frame non-AUG (CUG) and AUG start codons results in
            protein isoforms with different lengths. Differential translation
            initiation is mediated by an out-of-frame, upstream open reading
            frame which is located between the CUG and the first AUG start
            codons. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) can initiate translation from
            an upstream non-AUG (CUG) site, and also from three conserved
            downstream, in-frame AUG sites. The isoform (c, also known as
            extended) represented in this RefSeq results from translation
            initiation at the upstream CUG start codon. Isoform c is the
            longest isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.154041.1,
                                        SRR26643429.1696.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 20075868
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2673              JAXUCZ010000001.1  96896584-96899256
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="CCAAT/enhancer binding protein alpha"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
     exon            1..2673
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1198
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="isoform c is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; C/EBP alpha;
                     CAAT/enhancer-binding protein, DNA-binding protein;
                     CCAAT/enhancer binding protein (C/EBP), alpha"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein alpha isoform c"
                     /protein_id="NP_001274506.1"
                     /db_xref="GeneID:24252"
                     /db_xref="RGD:2326"
                     /translation="MRGRGRVGVLGGRRRQRRHAQAGGRRGSPCRENSNSPMESADFY
                     EAEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDIS
                     AYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAH
                     GPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQP
                     PPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPAMGA
                     AGLPGPGGSLKGLAGPHPDLRTGGGGGGGAGAGKAKKSVDKNSNEYRVRRERNNIAVR
                     KSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMG
                     NCA"
     misc_feature    122..124
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform a"
     misc_feature    164..166
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform d"
     misc_feature    473..475
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Region: alternative AUG start codon; isoform b"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    959..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein alpha (CEBPA): a
                     DNA-binding and dimerization domain; Region: bZIP_CEBPA;
                     cd14711"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    965..1141
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(974..979,983..988,992..1000,1004..1009,1013..1021,
                     1025..1027,1031..1033)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
     misc_feature    order(1040..1042,1049..1051,1058..1063,1070..1075,
                     1079..1084,1088..1096,1100..1105,1112..1117,1121..1126,
                     1133..1138)
                     /gene="Cebpa"
                     /gene_synonym="DBPCEP"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269859"
ORIGIN      
        1 cgacccaaag ctgcgcgggc gcgggcgagt tggggtactg ggtgggcggc ggcgacagcg
       61 gcgccacgcg caggctggag gccgccgagg ctcgccatgc cgggagaact ctaactcccc
      121 catggagtcg gccgacttct acgaggcgga gccgcggccc ccgatgagca gccacctcca
      181 gagccccccg cacgcgccca gcaacgccgc ctttggcttt ccccggggcg cgggccccgc
      241 gccgccccca gccccacctg ccgccccgga gccgctgggc ggcatctgcg agcacgagac
      301 gtctatagac atcagcgcct acatcgaccc ggccgccttc aacgacgagt tcctggccga
      361 cctcttccag cacagccggc agcaggagaa ggccaaggcg gcggcgggcc ccgcgggtgg
      421 cggcggtgac tttgactacc cgggcgcccc ggcgggcccc ggcggtgcgg tcatgtccgc
      481 gggggcgcac ggaccccctc ccggctacgg ctgtgcggcg gccggctacc tggacggcag
      541 gctggagccc ctgtacgagc gcgtcggggc gcccgcgctg cggccgctgg tgatcaagca
      601 ggagccccgc gaggaggacg aggcgaagca gctggcgctg gccggcctct tcccctatca
      661 gcccccgccg ccgccgccgc caccgcaccc gcacgcgtct cccgcgcact tggccgcccc
      721 tcacttgcag ttccagatcg cacactgcgg ccagaccacc atgcacctgc agcctggcca
      781 ccctacgccg ccgccgacgc ccgtgcccag ccctcatccc gcgcctgcaa tgggtgctgc
      841 gggcctgccg ggccccgggg gctcgctcaa gggcttggct ggtccgcacc ccgacctccg
      901 caccggcggc ggcggcggcg gcggggccgg cgcgggcaag gccaagaagt cggtggataa
      961 gaacagcaac gagtaccggg tacggcggga acgcaacaac atcgcggtgc gcaagagccg
     1021 agataaagcc aaacagcgca acgtggagac gcagcagaag gtgttggagt tgaccagtga
     1081 caatgaccgc ctgcgcaagc gggtggaaca gctgagccgt gaactggaca cgctgcgggg
     1141 tatcttccgc cagctgcctg agagctcctt ggtcaaggcc atgggcaact gcgcgtgagg
     1201 cgcgcggctg cgggaccgcc ttgagccggc cccctggctg gggacccgga ggatggttta
     1261 gggtcgctgg atctctaggc tgcccggacc gtgcaagcca ggactaggag attctggtgt
     1321 cgcctgaaag cctggcctgc tccgcgtgtc ccctcccttc ctctgagccg gactcggtgc
     1381 gtctaagatg agagggagtc aggccgtggt ggtttctcct ttagaccgag agacttctcc
     1441 gcggagctga gctgggagcc cggcagtttt agtattaagg aagtaacctt gtgccttgga
     1501 tactcaaaac tcgctccttt tcctaccgag tagggggagc aaacatgtgc cttgatattt
     1561 tatttggagg attcctgctt cctccagagc tgcagcaggc ccccatgaga aaaatgaagg
     1621 gtgcaggccc agggcaggag gaagattcag gaagctgagg tcccagcagt ccctgagctg
     1681 cccctccgtc cctgtcctta gaggggaggg acttagggag ttggggattt gagtcttaaa
     1741 agtgtcccca cccctagtta catggagatg gagggttctt agccccttgc ttttcgctcc
     1801 tccatctaca ttcctccccc cacccccagc ttacaacagg ccaggtttcc ttggtgagtt
     1861 cgtggagaag ggggcaacac ccccagtcag accagaaggc tgagttgtga actggccatg
     1921 tggttaagca agtggtagaa gacagggacc ttagtttctg gtcttggggt ggaggatgaa
     1981 gacactggga ccatccgcct tgtgtgtact gtatgtcgcc agccgctgtt gctgaaggaa
     2041 cttgaagcat aatcgatcca tcccagaggg actggagtta tgacaagctt cccaaatatt
     2101 ttgctttatc atctgatatc aacacttgta tctggtctct gtgtcccagc ggtgccttgt
     2161 gcaatgtcag tgtgcgcgtc tatgctaaac caccatttta tttggtcttt tgttttgttt
     2221 tggttttgct ctgattcttg ccaaaatgag actcttcacg aacggccagg ggaaggggct
     2281 gagtgaggct ctcattcttt ttggtttagg gatgtttggt ttttttgttt tgttttgttt
     2341 tgttttgttt tctttcgcct cccagaggac caatgaaatg aagtgggctt ctccctctcc
     2401 cctagttttc caagggtgta tgtagttgtg ggtcttagct tccttcctcc ggctgagact
     2461 tatactggct tccccaccca cccaccccca tccccaaagg ccctggctct gggtctggaa
     2521 agaaggccac ctccagccaa tttgtacaca accctgccac tggaagcagg ggtggactgc
     2581 ttccttctct tctttttttg gggggagggg acacaaagtt tcatgctaga tgtcctatgt
     2641 attatatcta taatataaac atatcaaact caa
//
LOCUS       NM_031020               3443 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus mitogen activated protein kinase 14 (Mapk14),
            mRNA.
ACCESSION   NM_031020
VERSION     NM_031020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3443)
  AUTHORS   Tu,Z., Jin,P., Wang,Q., Feng,Y., Chu,X., Fu,L., Hou,S. and Li,W.
  TITLE     Dynamically changed HSP70 after reperfusion following cerebral
            infarction in human and rats: correlation with p38 MAPK
  JOURNAL   Neuroreport 35 (7), 439-446 (2024)
   PUBMED   38597327
  REMARK    GeneRIF: Dynamically changed HSP70 after reperfusion following
            cerebral infarction in human and rats: correlation with p38 MAPK.
REFERENCE   2  (bases 1 to 3443)
  AUTHORS   Ye,H., He,S., Du,Y., Wang,Y., Hu,Y., Zhao,C., Jin,Y., Liu,F. and
            Guo,Y.
  TITLE     Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic
            shock
  JOURNAL   Apoptosis 29 (1-2), 154-168 (2024)
   PUBMED   37751106
  REMARK    GeneRIF: Involvement of CD44 and MAPK14-mediated ferroptosis in
            hemorrhagic shock.
REFERENCE   3  (bases 1 to 3443)
  AUTHORS   Zhu,P., Wu,X., Ni,L., Chen,K., Dong,Z., Du,J., Kong,F., Mao,Y.,
            Tao,H., Chu,M., Mao,H., Yang,H., Liu,Q., Gan,M. and Geng,D.
  TITLE     Inhibition of PP2A ameliorates intervertebral disc degeneration by
            reducing annulus fibrosus cells apoptosis via p38/MAPK signal
            pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166888 (2024)
   PUBMED   37722489
  REMARK    GeneRIF: Inhibition of PP2A ameliorates intervertebral disc
            degeneration by reducing annulus fibrosus cells apoptosis via
            p38/MAPK signal pathway.
REFERENCE   4  (bases 1 to 3443)
  AUTHORS   Sase,K., Tsukahara,C., Fujita,N., Arizono,I., Otsubo,M. and
            Kitaoka,Y.
  TITLE     Inhibition of p38 ameliorates axonal loss with modulation of
            autophagy in TNF-induced optic nerve damage
  JOURNAL   Int Ophthalmol 43 (9), 3067-3074 (2023)
   PUBMED   37062014
  REMARK    GeneRIF: Inhibition of p38 ameliorates axonal loss with modulation
            of autophagy in TNF-induced optic nerve damage.
REFERENCE   5  (bases 1 to 3443)
  AUTHORS   Muraleva,N.A. and Kolosova,N.G.
  TITLE     P38 MAPK Signaling in the Retina: Effects of Aging and Age-Related
            Macular Degeneration
  JOURNAL   Int J Mol Sci 24 (14), 11586 (2023)
   PUBMED   37511345
  REMARK    GeneRIF: P38 MAPK Signaling in the Retina: Effects of Aging and
            Age-Related Macular Degeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3443)
  AUTHORS   Hedges,J.C., Yamboliev,I.A., Ngo,M., Horowitz,B., Adam,L.P. and
            Gerthoffer,W.T.
  TITLE     p38 mitogen-activated protein kinase expression and activation in
            smooth muscle
  JOURNAL   Am J Physiol 275 (2), C527-C534 (1998)
   PUBMED   9688607
REFERENCE   7  (bases 1 to 3443)
  AUTHORS   Nemeth,E., Bole-Feysot,C. and Tashima,L.S.
  TITLE     Suppression subtractive hybridization (SSH) identifies prolactin
            stimulation of p38 MAP kinase gene expression in Nb2 T lymphoma
            cells: molecular cloning of rat p38 MAP kinase
  JOURNAL   J Mol Endocrinol 20 (1), 151-156 (1998)
   PUBMED   9513091
REFERENCE   8  (bases 1 to 3443)
  AUTHORS   Lee,J.C., Laydon,J.T., McDonnell,P.C., Gallagher,T.F., Kumar,S.,
            Green,D., McNulty,D., Blumenthal,M.J., Heys,J.R., Landvatter,S.W.,
            Strickler,J.E., McLaughlin,M.M., Siemens,I.R., Fisher,S.M.,
            Livi,G.P., White,J.R., Adams,J.L. and Young,P.R.
  TITLE     A protein kinase involved in the regulation of inflammatory
            cytokine biosynthesis
  JOURNAL   Nature 372 (6508), 739-746 (1994)
   PUBMED   7997261
REFERENCE   9  (bases 1 to 3443)
  AUTHORS   Han,J., Lee,J.D., Bibbs,L. and Ulevitch,R.J.
  TITLE     A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian
            cells
  JOURNAL   Science 265 (5173), 808-811 (1994)
   PUBMED   7914033
REFERENCE   10 (bases 1 to 3443)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1 and BC092193.1.
            
            On Mar 15, 2021 this sequence version replaced NM_031020.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092193.1, AB000783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                JAXUCZ010000020.1  6751359-6751375
            18-3443             BC092193.1         1-3426
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3443
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="mitogen activated protein kinase 14"
                     /db_xref="GeneID:81649"
                     /db_xref="RGD:70496"
     exon            1..436
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    171..173
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="upstream in-frame stop codon"
     CDS             321..1403
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /EC_number="2.7.11.24"
                     /note="MAP kinase p38 alpha; mitogen-activated protein
                     kinase p38 alpha; MAP kinase 14; p38 mitogen activated
                     protein kinase; MAPK 14; reactive kinase; MAP kinase 2;
                     cytokine-supressive anti-inflammatory drug binding
                     protein; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2;
                     Csaids binding protein; MAX-interacting protein 2;
                     stress-activated protein kinase 2A; cytokine suppressive
                     anti-inflammatory drug binding protein; mitogen-activated
                     protein kinase 14A"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 14"
                     /protein_id="NP_112282.2"
                     /db_xref="GeneID:81649"
                     /db_xref="RGD:70496"
                     /translation="MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDT
                     KTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV
                     YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
                     DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT
                     GRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIG
                     ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLI
                     DEWKSLTYDEVISFVPPPLDQEEMES"
     misc_feature    336..1370
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     p38alpha Mitogen-Activated Protein Kinase (also called
                     MAPK14); Region: STKc_p38alpha; cd07877"
                     /db_xref="CDD:143382"
     misc_feature    336..1370
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     p38alpha Mitogen-Activated Protein Kinase (also called
                     MAPK14); Region: STKc_p38alpha; cd07877"
                     /db_xref="CDD:143382"
     misc_feature    order(408..419,423..425,429..434,471..473,477..479,
                     528..530,543..545,570..572,576..578,630..632,636..647,
                     654..656,660..665,768..770,774..776,780..785,789..791,
                     819..824,828..833,858..860,864..875,879..881,993..995)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="active site"
                     /db_xref="CDD:143382"
     misc_feature    order(408..419,423..425,429..434,471..473,477..479,
                     528..530,543..545,570..572,576..578,630..632,636..647,
                     654..656,660..665,768..770,774..776,780..785,789..791,
                     819..824,828..833,858..860,864..875,879..881,993..995)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="active site"
                     /db_xref="CDD:143382"
     misc_feature    order(408..413,423..425,429..434,471..473,477..479,
                     543..545,570..572,576..578,630..632,636..647,654..656,
                     768..770,774..776,780..785,819..824,828..830)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    order(408..413,423..425,429..434,471..473,477..479,
                     543..545,570..572,576..578,630..632,636..647,654..656,
                     768..770,774..776,780..785,819..824,828..830)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    order(528..530,660..662,768..770,774..776,831..833,
                     858..860,864..875,879..881,993..995)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    order(528..530,660..662,768..770,774..776,831..833,
                     858..860,864..875,879..881,993..995)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    order(651..653,666..668,675..680,693..698,705..707,
                     792..806,1251..1253)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    order(651..653,666..668,675..680,693..698,705..707,
                     792..806,1251..1253)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:143382"
     misc_feature    819..881
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:143382"
     misc_feature    819..881
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:143382"
     misc_feature    order(891..896,903..905,909..911,915..923,1026..1028,
                     1044..1046,1056..1058,1065..1067,1095..1097,1191..1202)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="lipid binding site [chemical binding];
                     lipid-binding site"
                     /db_xref="CDD:143382"
     misc_feature    order(891..896,903..905,909..911,915..923,1026..1028,
                     1044..1046,1056..1058,1065..1067,1095..1097,1191..1202)
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /note="lipid binding site [chemical binding];
                     lipid-binding site"
                     /db_xref="CDD:143382"
     exon            437..566
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            567..625
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            626..737
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            738..767
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            768..815
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            816..930
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1002
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1082
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1335
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..3443
                     /gene="Mapk14"
                     /gene_synonym="CRK1; CSBP; Csbp1; Csbp2; CSPB1; Exip; Hog;
                     Mxi2; p38; p38alpha; p38Hog; Prkm14; Prkm15; RK; Sapk2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagatcgc ggccactgga gcccgagcgg gcgctagagc gcgagcggct gtcgcgcagc
       61 gtcggcgtgc gctccccagg gagcggctgc aaggggaccg cggcgggagc tgcgtcgaac
      121 cgtgcagccg gctcccgctc gttgccgagg ctcgtaggtg ccgccgcggc tgacaggagc
      181 cgtgggtcgc agcctccaca cctgcgcggg cgcggggtcg ggtctgccgc gggcgagcga
      241 gagggcgcag aggagagcgt gcggctgcag gcaggggccc tcgctcggcc acctcgtcgc
      301 cgcgctgccg ccgctggaag atgtcgcagg agaggcccac gttctaccgg caggagctga
      361 acaagaccgt ctgggaggtg cccgagcgat accagaacct gtccccggtg ggctcgggag
      421 cctacggctc ggtgtgtgct gcttttgata caaagacggg acatcgtgtg gcagtgaaga
      481 agctgtcgag accgtttcag tccatcattc acgccaaaag gacctacagg gagctgcggc
      541 tgctgaagca catgaagcac gagaatgtga ttggtctgtt ggatgtgttt acacctgcaa
      601 ggtccctgga ggaattcaac gatgtgtacc tggtgaccca tctcatgggg gcagacctga
      661 acaacatcgt gaagtgtcag aagcttaccg atgaccacgt tcagtttctt atctaccaga
      721 tcctgcgagg gctgaagtat atacactcgg ctgacataat ccacagggac ctaaagccca
      781 gcaacctcgc tgtgaatgaa gactgtgagc tgaagattct ggattttggg ctggctcggc
      841 acactgatga cgaaatgacc ggctacgtgg ctacccggtg gtacagagcc cccgagatta
      901 tgctgaattg gatgcactac aaccagacag tggatatttg gtccgtgggc tgcatcatgg
      961 ctgagctgtt gaccggaaga acgttgtttc ctggtacaga ccatattaac cagcttcagc
     1021 agataatgcg tctgacgggg acaccccctg cttatctcat taacaggatg ccaagccatg
     1081 aggcaagaaa ctacattcag tctctggccc agatgccgaa gatgaacttc gcaaatgtat
     1141 ttattggtgc caatcccctg gctgtcgacc tgctggaaaa gatgctggtt ttggactcgg
     1201 ataagaggat cacagcagcc caagctcttg cgcatgccta ctttgctcag taccacgacc
     1261 ctgatgatga gccagtggct gacccttatg accagtcctt tgaaagcagg gacctcctta
     1321 tagacgaatg gaagagcctg acctacgatg aagtcattag ctttgtgcca ccgccccttg
     1381 accaagaaga aatggagtcc tgagcacctt gcttctgttc tgtccatccc acttcactgt
     1441 gaggggaagg cctgttcatg ggaactctcc aaataccatt caagtgcctc ttgttgaaag
     1501 attccttcat ggtggaaggg ggtgcatgta tgtgcgtagt gtttgtgtgt gtctgtctgt
     1561 ctgtccgttt gtccatgtat ctttgtggaa gtcattgtga tggcagtgac ttcatgagtg
     1621 gtagatgctc cttggcagtc tgcctgctct ctcagagtcc gggcaggccg atgggaactg
     1681 ccgtctcctt agggatgtgt gtgtgtatgt taagtgcaaa gtaagaatat taaaatatcc
     1741 ctgttcctag ttaccttgcc acttcggctt ctcctgtggc cctgccttta ccatatcaca
     1801 gtgacagaga gaggctgctt caggtctgag gctatccctc agccatgcat aaagcccaag
     1861 agaaccaact ggctcctggg ctctagcctg tgatcggctt gctcatgtcc tcagaacctg
     1921 tcagtctgtt tgtgccttaa aaggagagaa gggcgcgttg tggtagttac agaatctcag
     1981 ttgctggcgt tctgagccag gcaaggcaca gggctgttgg atggccagtg gggagctgga
     2041 caaaacaagg cagccttcaa ggaggccatg ggtgcatgtg tgcatgagtg tatgtgcagc
     2101 cgccctccct cacctccagg agcaagctgt tttctatgct tacctaagtt cacctcagtg
     2161 cagaggtctc cagtgccagg cacaggctcc tgccatcagt agcttcctat gtcatcttca
     2221 cgtcatgcgg gtgtttgcat gctgtgctct ggagcttgtc ctgtcttctg gaagccctgg
     2281 gccgggcgtg tgaagacttc ccagcagtcc tatccacgca cctcagctga ggccacgggc
     2341 acactgctgc ttcctcactc cagctacgtt gtgttgaaca caactgatcc tccaggtgct
     2401 tgtggtgcag gaaacgggac gaacagagca cctgaaccct tgccatctga catcaccgac
     2461 acaggagaac agtcctctcc tctcctctcc tctcctctcc taggacagtc cccagctctg
     2521 gaatcatgtt cttctcactc atggtagcca gctaagaaag ctgcaaaccg aacaaaggga
     2581 gaaccgagct cctgaagcca ggagctcctt ttactgtcct tctcaaaata gggtcattag
     2641 acacagccaa gtcgtcaaag gcccctttcc ttgtacgggg cccccccgcc cccggcagct
     2701 tgacactgat ttcagtgtct atttggggag aaagcaattt tgtcttggaa ttttgtatgt
     2761 tgtaggaatc cttagagagt gtggttcctt ctgatgggga gaaagggcaa attattttaa
     2821 tattttgtat ttcaccttta taaacatgaa tcctcagggg tgaagaactg tttgcataat
     2881 tttctgaatt tcaggcactt tgtgctatat gaggacccat atatttaagc tttttgtgca
     2941 gtaagaaagt gtaaagccaa ttccagtgtt ggacgaaaca ggtctcgtat ttaggtcaag
     3001 gtgtctccat tctctatcag tgcagggaca tgcagttctg tggggcaggg taggaccctg
     3061 catcatctgg agcccagaag gaggccgact ggccaggcct caccgcctca gtatgcagtc
     3121 cagctccacg tcatcccctc acaatggtta gtagcaacgt ctgggtttga acgccaggcg
     3181 tggttatttt attgaggatg cctttgcaca tgtggccatg ctgtgttagg actgtgcccc
     3241 agggcccgga cttgaagcta gagctggcag aagagctcct ggcatccatg gtgcgatgct
     3301 gccgccaccc agtttctcca ttggaagaca agggaatgag aagactgctg tgtatgtgta
     3361 tttgtgaact tggttgtgat ctggtatgcc ataggatgtc agacaatacc actggttaaa
     3421 gtaaagccta tttttcagat tca
//
LOCUS       NM_001393859            2960 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 6 (Prmt6),
            transcript variant 2, mRNA.
ACCESSION   NM_001393859 XM_017590781
VERSION     NM_001393859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Yan,W.W., Liang,Y.L., Zhang,Q.X., Wang,D., Lei,M.Z., Qu,J.,
            He,X.H., Lei,Q.Y. and Wang,Y.P.
  TITLE     Arginine methylation of SIRT7 couples glucose sensing with
            mitochondria biogenesis
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30420520
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Casadio,F., Lu,X., Pollock,S.B., LeRoy,G., Garcia,B.A., Muir,T.W.,
            Roeder,R.G. and Allis,C.D.
  TITLE     H3R42me2a is a histone modification with positive transcriptional
            effects
  JOURNAL   Proc Natl Acad Sci U S A 110 (37), 14894-14899 (2013)
   PUBMED   23980157
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Neault,M., Mallette,F.A., Vogel,G., Michaud-Levesque,J. and
            Richard,S.
  TITLE     Ablation of PRMT6 reveals a role as a negative transcriptional
            regulator of the p53 tumor suppressor
  JOURNAL   Nucleic Acids Res 40 (19), 9513-9521 (2012)
   PUBMED   22904064
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Guccione,E., Bassi,C., Casadio,F., Martinato,F., Cesaroni,M.,
            Schuchlautz,H., Luscher,B. and Amati,B.
  TITLE     Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are
            mutually exclusive
  JOURNAL   Nature 449 (7164), 933-937 (2007)
   PUBMED   17898714
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   El-Andaloussi,N., Valovka,T., Toueille,M., Steinacher,R., Focke,F.,
            Gehrig,P., Covic,M., Hassa,P.O., Schar,P., Hubscher,U. and
            Hottiger,M.O.
  TITLE     Arginine methylation regulates DNA polymerase beta
  JOURNAL   Mol Cell 22 (1), 51-62 (2006)
   PUBMED   16600869
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Miranda,T.B., Webb,K.J., Edberg,D.D., Reeves,R. and Clarke,S.
  TITLE     Protein arginine methyltransferase 6 specifically methylates the
            nonhistone chromatin protein HMGA1a
  JOURNAL   Biochem Biophys Res Commun 336 (3), 831-835 (2005)
   PUBMED   16157300
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 19, 2021 this sequence version replaced XM_017590781.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.9256.1,
                                           SRR26360190.1237519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1182              JAXUCZ010000002.1  200619609-200620790 c
            1183-2960           JAXUCZ010000002.1  200615780-200617557 c
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..2960
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="protein arginine methyltransferase 6"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
     exon            1..1182
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1147
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /EC_number="2.1.1.125"
                     /note="HMT1 hnRNP methyltransferase-like 6"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 6"
                     /protein_id="NP_001380788.1"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
                     /translation="MSLSKKRKLESGVGGAGGEGAEEENGGEQEAAPPRPRRTKRERD
                     QLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQ
                     AGARRVYAVEASAIWQQAQEVVRLNGLEDRVHILPGPVETVELPEQVDAIVSEWMGYG
                     LLHESMLSSVLHARTKWLKEGGLLLPDSAELFVAPISDQMLEWRLGFWSQVKQHYGVD
                     MSCMESFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFR
                     CSCYGSAPLHGFAIWFQVTFPGGDSEKPLVLSTSPFHPATHWKQALLYLNEPVPVEQD
                     TDISGEITLLPSRDNPRRLRVLLRYKVGDHEEKTKDFAMED"
     misc_feature    170..>703
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    170..>703
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     exon            1183..2960
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctgcc gggaccaaga tgtcgctgag caagaaaaga aagcttgagt cgggggtcgg
       61 cggcgcagga ggggagggag ctgaggagga aaatggcggg gagcaggagg cagccccgcc
      121 acgaccccgg aggaccaagc gcgagcggga ccagctgtac tacgagtgct actccgacgt
      181 atcggtccac gaggagatga tcgccgaccg cgtccgcacc gacgcctacc gcctaggcat
      241 cctgaggaac tgggccgctc tgcgaggcaa gaccgtgctg gacgtgggcg caggcaccgg
      301 cattcttagc atcttctgcg cccaggccgg ggcccggcgc gtatacgctg tggaggccag
      361 cgccatctgg caacaggccc aggaggtggt gcggctcaac gggttggagg accgcgtgca
      421 catcctgcca ggcccggtgg agacggtgga gctgccggag caagtggacg ccatcgtaag
      481 cgagtggatg ggctacggac tactgcacga gtccatgctg agctccgtgc tccacgcgcg
      541 gaccaaatgg ctgaaggagg gcggtctcct cctgccagat tccgctgagc tcttcgtggc
      601 cccgattagc gaccagatgc tggaatggcg cttgggtttc tggagccaag tgaagcagca
      661 ctatggcgtg gatatgagct gcatggaaag cttcgccacg cgctgcctca tgggccattc
      721 ggagatcgtg gtgcagggtc tgtccggaga ggacgtgctg gcccggccac agcgctttgc
      781 ccagctcgag ctggcccgcg ctggcctgga gcaggagctg gaggccggtg tgggcgggcg
      841 cttccgctgc agctgctatg gctccgcgcc tctacatggt tttgccatct ggtttcaggt
      901 aacctttcct ggaggggact cggagaaacc tctggtgctg tccacctcac ctttccaccc
      961 ggccacgcac tggaagcagg cgctcctcta cttgaatgag ccggtgccgg tggaacaaga
     1021 tacagacatt tctggagaga tcaccctgct gccctcccgg gacaaccccc ggcgtctgcg
     1081 cgtacttctg cgctacaaag tgggggacca tgaggaaaag accaaagact ttgccatgga
     1141 ggactgagcg ttgccttttc tcccatctac cttcttagga aggcactgac agcatcgcct
     1201 tggctataca tgaagagcaa cgtatgccac ggggtaccag atgatccaaa gaagcaccac
     1261 agtctttggg atgaagacac ctgggaaaga ggaaagcctg aggtgtgtgg acacccaggc
     1321 actatctgat gtgttatgtg gattgggact ggtaactgaa acccttaggg ccacaggcct
     1381 ggattattag actctagaga gagcatcatg gtaaagtccc acctacctcc ctcacacctt
     1441 acctttattt agccctccca aatttcccaa ttttgtcgct aatttattaa accaatgagc
     1501 ataatacatt ctaaaggtca ctgtggtagg tatttgggat tacatgctac ttgaactctg
     1561 cccataagta gatgtctaca ctaaaggaag taaaggccat aattttaggt tagttaggac
     1621 ctgggtggtt ttagtgtcag aaaagatgga ttatttgttt tacacactaa gtgaaaaagg
     1681 tttcgtagat gctgacagaa agttacatac ataattcttc ctggtttgga aatgtgatca
     1741 tacattgtgc aaggctaaat tggaacccag gatatagctg aggatgactt tgaactcttt
     1801 cctccacctt ccacattctg gagttaatag ctctgtacca ctgtgcccag catagaccca
     1861 gtttttggct gacccttacc cacaattctt gacttttcaa aggtaaacaa aaatttactc
     1921 tcatattaat cccacatgct tcacttaaaa acaggagact atgtgccacc ttaatagtaa
     1981 caagggcttt attatttgat gatgacggga aagtgtttag tactagaaag gctcttagac
     2041 ctgcccaaaa gaaacatctg cagtgtgtaa cttgagtttg acatagtggg cactcatttc
     2101 aacagccctt atgtttattt ctgtaacaat agtcaaatgg gacactttct agggtctcca
     2161 gaaaactgaa tgcatgacag tagcaaagac aagtgaactc cctgtcattt gggcagggat
     2221 gtaaaagaga caagaaaatg gagttcaaga aagtgaatgt gaaaagcacc tgctgcgaac
     2281 agctgcctgc cgtcttcttt actgccagct ttgctcttat ccccacagtt tacctagtgc
     2341 tgaggaaaga tggctcctaa ggagcattta ctaacaggcc ccactcctcc acatgttcat
     2401 ctctgtatat gtctctccat taatttcatt atcaacagct acataatagc taagcactgt
     2461 aataactgag cacatctgcc cttcagagaa cagggtacag tgggagcagt aaagcagcat
     2521 cagttgttct catgcattcg taagcctgga aatccttccc agctcttagc tctgctgagt
     2581 gagtatggaa agggtgctgt caccctttaa ggctctctga ggatcaaagg tctgattcct
     2641 atcagcagga agattgtgaa cacctgagaa actcccatct gatgttctag aattagacag
     2701 tattccccaa aatactagtc tgttccataa tagaccaact atattaaata ggtaatcccc
     2761 agctactaaa acaaagactc taagccaagt ttatgggtcg tctgtgtgtc tgtgtgtata
     2821 ctgtgtgtat actgtgtgcg cgagtgtgtg catgtgcaca tttgcttgta tcttccccaa
     2881 ctttctgtgt gatttttatg cttcaatttg tttatgattt atcctctcac ttttaataaa
     2941 tattacatgt attttttgaa
//
LOCUS       NM_001100499            2861 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus plakophilin 2 (Pkp2), mRNA.
ACCESSION   NM_001100499 XM_001065241 XM_213560
VERSION     NM_001100499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   de Paiva Lima,C., da Silva E Silva,D.A., Damasceno,S.,
            Ribeiro,A.F., Rocha,C.S., Berenguer de Matos,A.H., Correia,D.,
            Boerngen-Lacerda,R. and Brunialti Godard,A.L.
  TITLE     Loss of control over the ethanol consumption: differential
            transcriptional regulation in prefrontal cortex
  JOURNAL   J Neurogenet 31 (3), 170-177 (2017)
   PUBMED   28714806
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Moncayo-Arlandi,J., Guasch,E., Sanz-de la Garza,M., Casado,M.,
            Garcia,N.A., Mont,L., Sitges,M., Knoll,R., Buyandelger,B.,
            Campuzano,O., Diez-Juan,A. and Brugada,R.
  TITLE     Molecular disturbance underlies to arrhythmogenic cardiomyopathy
            induced by transgene content, age and exercise in a truncated PKP2
            mouse model
  JOURNAL   Hum Mol Genet 25 (17), 3676-3688 (2016)
   PUBMED   27412010
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Dubash,A.D., Kam,C.Y., Aguado,B.A., Patel,D.M., Delmar,M.,
            Shea,L.D. and Green,K.J.
  TITLE     Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic
            gene expression in cardiomyocytes
  JOURNAL   J Cell Biol 212 (4), 425-438 (2016)
   PUBMED   26858265
  REMARK    GeneRIF: Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent
            fibrotic gene expression in cardiomyocytes.
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Fischer-Keso,R., Breuninger,S., Hofmann,S., Henn,M., Rohrig,T.,
            Strobel,P., Stoecklin,G. and Hofmann,I.
  TITLE     Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA
            stability of desmosomal proteins
  JOURNAL   Mol Cell Biol 34 (23), 4244-4256 (2014)
   PUBMED   25225333
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Franke,W.W., Borrmann,C.M., Grund,C. and Pieperhoff,S.
  TITLE     The area composita of adhering junctions connecting heart muscle
            cells of vertebrates. I. Molecular definition in intercalated disks
            of cardiomyocytes by immunoelectron microscopy of desmosomal
            proteins
  JOURNAL   Eur J Cell Biol 85 (2), 69-82 (2006)
   PUBMED   16406610
  REMARK    Erratum:[Eur J Cell Biol. 2006 Jun;85(6):577.]
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Gerull,B., Heuser,A., Wichter,T., Paul,M., Basson,C.T.,
            McDermott,D.A., Lerman,B.B., Markowitz,S.M., Ellinor,P.T.,
            MacRae,C.A., Peters,S., Grossmann,K.S., Drenckhahn,J., Michely,B.,
            Sasse-Klaassen,S., Birchmeier,W., Dietz,R., Breithardt,G.,
            Schulze-Bahr,E. and Thierfelder,L.
  TITLE     Mutations in the desmosomal protein plakophilin-2 are common in
            arrhythmogenic right ventricular cardiomyopathy
  JOURNAL   Nat Genet 36 (11), 1162-1164 (2004)
   PUBMED   15489853
  REMARK    Erratum:[Nat Genet. 2005 Jan;37(1):106]
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Grossmann,K.S., Grund,C., Huelsken,J., Behrend,M., Erdmann,B.,
            Franke,W.W. and Birchmeier,W.
  TITLE     Requirement of plakophilin 2 for heart morphogenesis and cardiac
            junction formation
  JOURNAL   J Cell Biol 167 (1), 149-160 (2004)
   PUBMED   15479741
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Hofmann,I., Mertens,C., Brettel,M., Nimmrich,V., Schnolzer,M. and
            Herrmann,H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Gallicano,G.I., Kouklis,P., Bauer,C., Yin,M., Vasioukhin,V.,
            Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is required early in development for assembly of
            desmosomes and cytoskeletal linkage
  JOURNAL   J Cell Biol 143 (7), 2009-2022 (1998)
   PUBMED   9864371
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Nov 30, 2008 this sequence version replaced
            XM_001065241.1, XM_213560.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2861
                     /gene="Pkp2"
                     /note="plakophilin 2"
                     /db_xref="GeneID:287925"
                     /db_xref="RGD:1306533"
     exon            1..260
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2425
                     /gene="Pkp2"
                     /codon_start=1
                     /product="plakophilin-2"
                     /protein_id="NP_001093969.1"
                     /db_xref="GeneID:287925"
                     /db_xref="RGD:1306533"
                     /translation="MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSS
                     GRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQS
                     PAARDYDMLKAGVTATYGSRWGRGTAQYSSQKSVEERSWRQPLRRLEISPDSSPERAH
                     YGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQTGTARRAPGCGSVSDAVFDNGPL
                     NPTIPTHPPGTSHSAGSLLEETTVRVSQARFQGLQSRAGRSSWPRSSVHSTLRESGRM
                     LPTAGQAAVGSGDAHRDRSAFADSQLGNADLEMTLERAVNMLDADHVPLSKISAAATF
                     IQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVA
                     ELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFS
                     GWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTI
                     ADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRS
                     RKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLT
                     AGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAK
                     ETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTIS
                     IGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD"
     misc_feature    968..1051
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    968..1051
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    order(1016..1018,1028..1030,1046..1048,1148..1150,
                     1160..1162,1172..1174,1277..1279,1289..1291,1301..1303)
                     /gene="Pkp2"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    order(1016..1018,1028..1030,1046..1048,1148..1150,
                     1160..1162,1172..1174,1277..1279,1289..1291,1301..1303)
                     /gene="Pkp2"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:293788"
     misc_feature    1061..1183
                     /gene="Pkp2"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1061..1183
                     /gene="Pkp2"
                     /note="Armadillo/beta-catenin-like repeats; Region: ARM;
                     smart00185"
                     /db_xref="CDD:214547"
     misc_feature    1073..1183
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1073..1183
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1199..1306
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1199..1306
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1340..1474
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1340..1474
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1787..1912
                     /gene="Pkp2"
                     /note="Armadillo/beta-catenin-like repeat; Region: Arm;
                     pfam00514"
                     /db_xref="CDD:425727"
     misc_feature    1787..1912
                     /gene="Pkp2"
                     /note="Armadillo/beta-catenin-like repeat; Region: Arm;
                     pfam00514"
                     /db_xref="CDD:425727"
     misc_feature    1943..2047
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    1943..2047
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2069..2185
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     misc_feature    2069..2185
                     /gene="Pkp2"
                     /note="armadillo repeat [structural motif]; Region:
                     armadillo repeat"
                     /db_xref="CDD:293788"
     exon            261..373
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..945
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1081
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1289
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1467
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1585
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1750
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1924
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2078
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2268
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2356
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2861
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctggcag tcctttcctg gtcaccttgc ggacgccatg gcgatcccag gctcactggg
       61 cgagtgtggt tacatccgga ccgtgctggg ccagcagatc ctgggtcacc tggacagctc
      121 cagcctggcc ttgccctccg aggccaggct gaggctagcg ggcagcagcg gccgcggcga
      181 cccggtggcc cggagccagc ggatccagga gcaggtgcag caaaccctgg ctcgccgggg
      241 ccggagctct gtagtcggcg ggaaccttca ccgaaccagc agtgttcctg agtatgtcta
      301 caagctgcac ttggttgaga atgactttgt tggaaggcag tcacctgccg ctagggacta
      361 tgacatgctt aaggctggag tgactgccac ttacggaagt cgttggggga gaggaacagc
      421 acagtatagt tcgcagaagt cagtagagga gagatcctgg aggcagcccc tgaggagact
      481 tgagatttcc ccagatagca gcccggagag agcccactat gggcacagcg aataccaata
      541 tgcctggcgg agccatgtgg tgcctggtgg gcgccttacc cttccacgct atgctcgctc
      601 agagatcctg ggcctgcgcc agactggcac agcccgaagg gcacctgggt gcgggtcagt
      661 cagcgatgct gtctttgaca atggcccgct taaccccacc atacccaccc accctcctgg
      721 caccagccac agcgcaggca gcctgctgga ggagaccact gtgcgtgtga gccaggctcg
      781 atttcagggc ctgcagagca gagccggccg ctcctcctgg ccccggagct cagtccacag
      841 taccttgcgg gagtcaggaa gaatgctgcc caccgcaggc caggctgcgg tgggcagcgg
      901 ggatgcgcat cgggacagga gcgccttcgc tgactcccag ctcgggaatg cagacttaga
      961 gatgaccttg gagcgagctg tgaatatgct ggatgcagac catgtaccac tgtccaagat
     1021 ctctgctgcg gctaccttca tacagcatga gagcttccaa aaatctgaag cacggaaaag
     1081 ggtcaatcaa cttcaaggca tccctaaact tctgcagctg ctcaaagttc agaatgaaga
     1141 cgttcagcgg gctgtgtgtg gggccctgag aaatttggta tttgaagaca atgataacaa
     1201 gttggaggtc gctgaactga atggagtgcc tcggctgctg caggtgctga agcaaaccag
     1261 agacttggag acaaagaagc aaataacagg tttgctctgg aacttgtcct ctagtgataa
     1321 actcaagcat ctcatgataa cagaagcctt gctcaccttg acagagagtg tcatcatccc
     1381 cttctcaggg tggcctgaag gagactaccc caaagccaat ggcttgcttg attttgatat
     1441 attctacaat gtcactggat gcctaagaaa catgagctcc gctggccctg atgggaggaa
     1501 ggtgatgagg aggtgtgatg gtctcattga ttcattggtc cattacgtca gaggaaccat
     1561 tgcagactac cagccagatg ataaggccac agagaactgc gtatgcattc ttcataacct
     1621 ctcctaccag ctggaggctg agctcccaga gaaatattcc cagagtatct acatgcaaaa
     1681 ccggaatatc cagaccaaca gtaacaaaag catcgggtgt tttggcagcc ggagtagaaa
     1741 agtaaaggag caataccaag acacgccgat gccagaggaa aggagcagtc cccgtggcat
     1801 tgagtggctg tggcattcca ttgtgataag gatgtatttg tccttaattg ccaagagttc
     1861 ccgaaactat acccaagagg catcattggg agctctccag aacctcacag caggaagcgg
     1921 cccgataccc acatcggtag ctcgcatggt tgtccagaag gaaaatggtc ttcagcacac
     1981 ccggaagatg ctgcacgtgg gtgatcccag tgtgaaaaag actgcagtct ccctgctgag
     2041 gaatttgtca cggaatcttt ctctgcagaa tgaaattgct aaagaaactc taccagattt
     2101 ggtttctata attcctgaca cagtcccaag tactgacctc ctcattgaaa ctacagcttc
     2161 tgcttgctat acgttgaaca atttaatgca aaatagttac cagaatgcac gagaccttct
     2221 gaacactgga gggctgcaga aaattatgac catcagcata ggagaaggct atgcccccaa
     2281 caaggccagc aaagctgcct ctgtcctcct gtactctctg tgggcacaca ccgagctcca
     2341 taatgcctac aagaaggctc agtttaagaa gacggacttc gtcaacagcc ggactgccaa
     2401 ggcctcccac tcccttaaag actaataagg agaagacgac tcaggaactc cagcttcaca
     2461 attctccact gaaaaaataa aacaaaaaac aaaaaacaaa aaaaaaatcc ccaaagaaaa
     2521 cacctatttt tctactaact gacccaagaa acctcaaaaa gcatgctttg tttatactct
     2581 tttctatttt catcccccaa atctagtaac gaatatctga atatgatttt gttagacatc
     2641 ctggagactt gccaggtcgc accagtgtgg aatccgtgtt ccctgtgcag atgatgggca
     2701 tcagtatcca ggcttatgta cacccatgtg ggtgctcatc ggaggaatct gaggaagcct
     2761 agtcacttgt ctgcatgtca cctccttagt gagccagagg tgtgtgtgca ccagtgctgc
     2821 acaggaccca agtgcaggaa taaagctttg atggcagatc a
//
LOCUS       NM_001191596            4594 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus ubiquitin specific peptidase 46 (Usp46), mRNA.
ACCESSION   NM_001191596 XM_214034
VERSION     NM_001191596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M.,
            Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and
            Sanyal,S.
  TITLE     Usp12 stabilizes the T-cell receptor complex at the cell surface
            during signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (6), E705-E714 (2016)
   PUBMED   26811477
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Huo,Y., Khatri,N., Hou,Q., Gilbert,J., Wang,G. and Man,H.Y.
  TITLE     The deubiquitinating enzyme USP46 regulates AMPA receptor
            ubiquitination and trafficking
  JOURNAL   J Neurochem 134 (6), 1067-1080 (2015)
   PUBMED   26077708
  REMARK    GeneRIF: USP46-mediated regulation of
            Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
            ubiquitination and turnover may play an important role in synaptic
            plasticity and brain function.
            Erratum:[J Neurochem. 2017 May;141(3):472. doi: 10.1111/jnc.14023.
            PMID: 28417468]
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Imai,S., Kano,M., Nonoyama,K. and Ebihara,S.
  TITLE     Behavioral characteristics of ubiquitin-specific peptidase
            46-deficient mice
  JOURNAL   PLoS One 8 (3), e58566 (2013)
   PUBMED   23472206
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Imai,S., Mamiya,T., Tsukada,A., Sakai,Y., Mouri,A., Nabeshima,T.
            and Ebihara,S.
  TITLE     Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile
            behavior in the tail suspension test through the GABAergic system
  JOURNAL   PLoS One 7 (6), e39084 (2012)
   PUBMED   22720038
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Zhang,W., Tian,Q.B., Li,Q.K., Wang,J.M., Wang,C.N., Liu,T.,
            Liu,D.W. and Wang,M.W.
  TITLE     Lysine 92 amino acid residue of USP46, a gene associated with
            'behavioral despair' in mice, influences the deubiquitinating
            enzyme activity
  JOURNAL   PLoS One 6 (10), e26297 (2011)
   PUBMED   22043315
  REMARK    GeneRIF: results suggest that the Lys 92 deletion of USP46 could
            influence enzyme activity and thereby provide a molecular clue how
            the enzyme regulating the pathogenesis of mental illnesses.
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Tomida,S., Mamiya,T., Sakamaki,H., Miura,M., Aosaki,T., Masuda,M.,
            Niwa,M., Kameyama,T., Kobayashi,J., Iwaki,Y., Imai,S., Ishikawa,A.,
            Abe,K., Yoshimura,T., Nabeshima,T. and Ebihara,S.
  TITLE     Usp46 is a quantitative trait gene regulating mouse immobile
            behavior in the tail suspension and forced swimming tests
  JOURNAL   Nat Genet 41 (6), 688-695 (2009)
   PUBMED   19465912
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Cohn,M.A., Kee,Y., Haas,W., Gygi,S.P. and D'Andrea,A.D.
  TITLE     UAF1 is a subunit of multiple deubiquitinating enzyme complexes
  JOURNAL   J Biol Chem 284 (8), 5343-5351 (2009)
   PUBMED   19075014
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_214034.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211578.1, SRR26643429.46605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000014.1  34504150-34504261
            113-193             JAXUCZ010000014.1  34535126-34535206
            194-407             JAXUCZ010000014.1  34539293-34539506
            408-637             JAXUCZ010000014.1  34542211-34542440
            638-714             JAXUCZ010000014.1  34555744-34555820
            715-798             JAXUCZ010000014.1  34566186-34566269
            799-996             JAXUCZ010000014.1  34568648-34568845
            997-1075            JAXUCZ010000014.1  34569228-34569306
            1076-4594           JAXUCZ010000014.1  34569800-34573318
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4594
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="ubiquitin specific peptidase 46"
                     /db_xref="GeneID:289584"
                     /db_xref="RGD:1564808"
     exon            1..112
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    38..40
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="upstream in-frame stop codon"
     CDS             77..1177
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 46; ubiquitin
                     thioesterase 46; deubiquitinating enzyme 46;
                     ubiquitin-specific-processing protease 46"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 46"
                     /protein_id="NP_001178525.1"
                     /db_xref="GeneID:289584"
                     /db_xref="RGD:1564808"
                     /translation="MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTC
                     YCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKF
                     ISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAEN
                     SKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNT
                     ETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVF
                     PLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK
                     IDAQAIEEFYGLTSDISKNSESGYILFYQSRE"
     misc_feature    182..1165
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19G; cd02663"
                     /db_xref="CDD:239128"
     misc_feature    182..1165
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     Peptidase_C19G; cd02663"
                     /db_xref="CDD:239128"
     misc_feature    order(191..193,206..208,1013..1015,1061..1063)
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="active site"
                     /db_xref="CDD:239128"
     misc_feature    order(191..193,206..208,1013..1015,1061..1063)
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /note="active site"
                     /db_xref="CDD:239128"
     exon            113..193
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            194..407
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            408..637
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            638..714
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            715..798
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            799..996
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1075
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..4594
                     /gene="Usp46"
                     /gene_synonym="RGD1564808"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcgcc accatggaca gtcccgtttt cccctggtaa agatggcggt gcgcgatcgc
       61 tgcaaccttt agactaatga ctgtccgaaa catcgcctcc atctgtaata tgggcaccaa
      121 tgcctctgct ctggaaaaag acattggacc agagcagttt ccgatcaatg aacactactt
      181 cggattggtc aattttggga acacatgcta ctgtaactcc gtgctccaag cattgtactt
      241 ctgccggccg ttccgggaga atgtgttggc atacaaggcc cagcagaaaa agaaggaaaa
      301 cctgttgacg tgcctggcag accttttcca cagcattgcc acgcagaaga agaaggttgg
      361 cgtcatccca ccaaagaagt tcatttcaag gctgaggaaa gagaacgatc tctttgataa
      421 ctacatgcag caggatgctc atgaattttt aaattatttg ctaaacacta ttgcggacat
      481 cctgcaggaa gagaagaaac aggaaaaaca aaacgggaaa ttaaaaaatg gcaacatgaa
      541 tgagccggca gagaatagta agccagaact cacctgggtc cacgagattt ttcagggaac
      601 actcactaac gaaactcgat gcttgaactg tgaaactgtg agtagcaaag acgaagattt
      661 tcttgacctc tctgttgatg tggaacagaa cacctccatc acccattgtc tgagagactt
      721 cagcaacaca gaaacgctgt gtagtgagca aaagtactat tgtgaaacat gctgcagcaa
      781 acaggaggct cagaagagga tgagggtaaa aaagctgccc atgattttgg ccctgcacct
      841 aaagaggttc aagtacatgg agcagctcca caggtacacc aagctgtctt accgggtggt
      901 cttccctctg gagctccggc tcttcaacac ctccagcgat gctgtcaacc tggaccgcat
      961 gtatgacctg gttgctgtcg tcgttcactg tggaagtggt cctaaccgtg ggcattacat
     1021 caccatcgtg aaaagtcatg gcttttggct attgtttgat gacgacatcg tagagaaaat
     1081 agatgctcaa gccattgagg aattctatgg tctaacgtca gacatatcaa aaaattcaga
     1141 atctggatat attttattct atcaatcaag agaataactt ggtggagcgt gagactaatt
     1201 caagcaggga gatactcaaa gcactagagc cttgtttctc tgcagacctc ccttcccccc
     1261 agcggcccac tgatgttatc actctgatgc ccactgttct ggcagtgtta aacttccttc
     1321 cttcgtgttt ttacatgcag cactactcct ggttctgttt tggtctgagg tagagttaac
     1381 tgcggtcaga ttatagttgg atttgtaact gttgctaatt ttaagattgg ggtgaatgtt
     1441 atgccgtttg tcatgtctga ctaaactaga gtgatatcgc ctgtaaatgt catggtccat
     1501 actgagtgtt tggtaggctt cctgaatggt ttctggggcc tcctttccat gcattccttc
     1561 gataggtccc tggaagcatt gctaccgttg ttagcatgcc tgtctcctct gatgggagga
     1621 gttgggtaga tagatattca tctgttaggg ctgcaaccat agctttaagt ttgtgctagt
     1681 gaaaatgttt taaagtgagt ggcctagatg ccgaaatcat cctccacatt ggagcaaggt
     1741 gaggtagggc tgtcattggt ggccggtgtt tgcacccagc tgtgcttacc tagctggtag
     1801 aatcccaggg gctaaggcac tgtggagctc agggcaggca aagccaagag gaagatgttt
     1861 ttgtggtcag tgaaaagtta cttatctttc taccaaaagc cacatttcag gaaaagagcg
     1921 caatgctgtt catttttagt aatacttttc ttccattggg tcctgtagtt gtatttttct
     1981 cctatttggt accactaggc ttttcaagct gcatttcctg tactgtggat gttttgcatt
     2041 gagtggtacc agggctgaga caccagctga ctgcctctgg caggtctctc tctagccagt
     2101 caacaccaac atctgcccta gatgaggaag atgaatcaaa aaactctgtt cagcagatta
     2161 tactgcttcc tcctcctctt cctcctcctc tcctcctttc tcttcctcct cctcttcctc
     2221 ctcctctttc ttcacattca gtctgtttaa ggaggcactg gtgagtccca gggatgaaac
     2281 attactctcc ctgaagggaa tgctggagtt agtggagtgt gtggtggatc acaggaagtg
     2341 ttaggaggtg ggcggagggc taagatggcg gctgtttctc tggctcagat tcctagaatg
     2401 cttgacaaga cagtttcctg gaagaacctc gtcttaccat tttccccttt tgttatatgt
     2461 gtatttatta gagcatttgc atattggcac cttttattaa aagggttgat ttggtgtctt
     2521 gccatcgaat ggatcttggt tttcctacaa atactatgag tcatagtcct tagcttcctt
     2581 tgggacgtca gttgacttcc acacactata atatactgtg aacgtgttac gttgtgacgt
     2641 aatacgtcgg cgaatgaaca tgcaaactct tggcgtaatg tgaactgaaa ctgcagttga
     2701 aaatgtcagt ggccattttg cagcaacgaa gaggatagca ctttatctag gtgaaaactg
     2761 gacttctcat ttctgaaata tcttgaattg tttgtgactc agaacttaag catgctgacg
     2821 cttccttcgt tcatgcttga agggacatgt ttcattcttc attggagcag acaaaacagg
     2881 gttatgtcat gttactctct tatgcaagtg acgaaaacgg accttgcctt ggttagaggc
     2941 aatgcatatt tataaatatt ttgtcttttt ttcccctcca tggagcatat ttattaatca
     3001 cttacgttgg aggtgaacct tcattcttcg aggagaggca cttttcaagt ataagtgatt
     3061 gatggcctga ggtgttcgga cacatacagc catatacttg actgtgagtt acaaaggtta
     3121 agaaaatggc tactggtttc taatatattt ggaactgatc atagaacaaa acctattaaa
     3181 actatctttg aaacaactct cgcagctaat ttattagaca aagaaaaatg tttccattgg
     3241 aagtccaaat gctattttaa ggttcttttc tttctttttc ttccttcctc ttgattctgt
     3301 gagcatgtaa agttttcccc agcaacataa ccaaagtcat tgcttttaat ggaaaaagta
     3361 agttaaaatt cagaattcac gaagaggttt tggaacagaa ggagatgagg gtgaggctat
     3421 tgcactgaca ttcagttggt tgtttggtgc ctgaatagaa gcctggagaa gaccaagact
     3481 ctatcaacac tccattggtt tttcaaacgt agaactatct ggtaatgact tatctctttg
     3541 tcagtaaaga aaacaccagg cagctctgtc ccaaccccca tcttcttttt tttttttcca
     3601 tagagaagtc atattctaac ttactatccc tggttcctag cattaagcag ggaatgacag
     3661 aggctgtggg acataggaga ccaattccag gtcacagaga tagcacaaag acccagcaac
     3721 agtccccaag gggggttcat atgccctttc tccagcagga gtgagtaagc ctgctgaatt
     3781 tttcttaatt tctgtaaaag ctgggtattt aaaaagaaaa gtgtctttca agagactaaa
     3841 aattttttaa aaaaacaaaa tgtttctttt atcggttatt tgctacttta acgtctagag
     3901 tatggtgcag aatggtaaat cttttgtttc aaagcaaacg ttagtcaaat ggtggtgtgc
     3961 atagtcttac tacattgatg cagctttttc cattccaagg catcatcagg tagactgact
     4021 tgaggagagc caggaataca atcagggtgt cagtcagaat aggaagccat tcccacatgg
     4081 ctttgtgtcc tgattatatt ttgggcttga cgtaagatgg gaaatgatag aaatggtccc
     4141 tgtgcgttgt tttcacggga acccttaatc taatgggcat gcctaacttg aaagtctgtt
     4201 ctaactggcg cttaaggctt attttagata ctggagtgta gctttattat ggatggagtc
     4261 tatcttttaa acatttcatt ttgatcaact ttgtatattc atgtgtatta aaatatcgtg
     4321 cactaaatgt cccccacccc atcccccagt ttgctgtatc tggtcagggc atttgccagc
     4381 accgatgtga ttagctcatg taaatggcat gggccagaga aaattattgc ctatttttct
     4441 gcctaattaa atttctgttt tctagtatta cattaattta tttttgactc ctatttctgt
     4501 aaccaaaata gttactgtat gtgtgtggca ttcacttgat tttgtcactt aaaaaagaaa
     4561 aaaaaagcct gtagttttta tttaaaatca gtat
//
LOCUS       NM_001271385            2012 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 8 (Prmt8),
            mRNA.
ACCESSION   NM_001271385 XM_001071456 XM_002726433
VERSION     NM_001271385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Zou,Z., Liu,R., Wang,Y., Tan,H., An,G., Zhang,B., Wang,Y. and
            Dong,D.
  TITLE     Protein arginine methyltransferase 8 regulates ferroptosis and
            macrophage polarization in spinal cord injury via glial
            cell-derived neurotrophic factor
  JOURNAL   CNS Neurosci Ther 29 (8), 2145-2161 (2023)
   PUBMED   36914965
  REMARK    GeneRIF: Protein arginine methyltransferase 8 regulates ferroptosis
            and macrophage polarization in spinal cord injury via glial
            cell-derived neurotrophic factor.
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Lo,L.H., Dong,R., Lyu,Q. and Lai,K.O.
  TITLE     The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1
            Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic
            Spine Maturation
  JOURNAL   Cell Rep 31 (10), 107744 (2020)
   PUBMED   32521269
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Toma-Fukai,S., Kim,J.D., Park,K.E., Kuwabara,N., Shimizu,N.,
            Krayukhina,E., Uchiyama,S., Fukamizu,A. and Shimizu,T.
  TITLE     Novel helical assembly in arginine methyltransferase 8
  JOURNAL   J Mol Biol 428 (6), 1197-1208 (2016)
   PUBMED   26876602
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Pahlich,S., Zakaryan,R.P. and Gehring,H.
  TITLE     Identification of proteins interacting with protein arginine
            methyltransferase 8: the Ewing sarcoma (EWS) protein binds
            independent of its methylation state
  JOURNAL   Proteins 72 (4), 1125-1137 (2008)
   PUBMED   18320585
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Sayegh,J., Webb,K., Cheng,D., Bedford,M.T. and Clarke,S.G.
  TITLE     Regulation of protein arginine methyltransferase 8 (PRMT8) activity
            by its N-terminal domain
  JOURNAL   J Biol Chem 282 (50), 36444-36453 (2007)
   PUBMED   17925405
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Lee,J., Sayegh,J., Daniel,J., Clarke,S. and Bedford,M.T.
  TITLE     PRMT8, a new membrane-bound tissue-specific member of the protein
            arginine methyltransferase family
  JOURNAL   J Biol Chem 280 (38), 32890-32896 (2005)
   PUBMED   16051612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Sep 21, 2012 this sequence version replaced
            XM_001071456.3, XM_002726433.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2249953.1,
                                           SRR22399492.871561.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000004.1  162303271-162303345 c
            76-261              JAXUCZ010000004.1  162266345-162266530 c
            262-417             JAXUCZ010000004.1  162262458-162262613 c
            418-481             JAXUCZ010000004.1  162259193-162259256 c
            482-624             JAXUCZ010000004.1  162244788-162244930 c
            625-712             JAXUCZ010000004.1  162244150-162244237 c
            713-828             JAXUCZ010000004.1  162236696-162236811 c
            829-979             JAXUCZ010000004.1  162230695-162230845 c
            980-1101            JAXUCZ010000004.1  162223569-162223690 c
            1102-2012           JAXUCZ010000004.1  162221986-162222896 c
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2012
                     /gene="Prmt8"
                     /note="protein arginine methyltransferase 8"
                     /db_xref="GeneID:688502"
                     /db_xref="RGD:1587677"
     CDS             1..1185
                     /gene="Prmt8"
                     /EC_number="2.1.1.319"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 8"
                     /protein_id="NP_001258314.1"
                     /db_xref="GeneID:688502"
                     /db_xref="RGD:1587677"
                     /translation="MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQ
                     CVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNS
                     MYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDN
                     VITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDR
                     AALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIK
                     EVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTH
                     WKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYK
                     MR"
     misc_feature    256..>777
                     /gene="Prmt8"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    256..>777
                     /gene="Prmt8"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     exon            1..75
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            76..261
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            262..417
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            418..481
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..624
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            625..712
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            713..828
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            829..979
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1101
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2012
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcatga aacactcctc ccgctgcctg ctcctccgga ggaaaatggc ggagaacgca
       61 gtcgaaagca cggaggtgag cagtgccccc cctcagcccc ctcagcctgt cattccagcg
      121 aagcctgtgc aatgcgtcca ccatgtgtcc acacagccca gctgcccagg acggggcaag
      181 atgtccaagc tgctgaatcc cgaggagatg acatcgagag attactattt tgactcatat
      241 gctcactttg ggatccacga ggaaatgctg aaggatgagg tgaggacact cacgtaccgg
      301 aactccatgt accataataa gcacgtgttc aaggacaaag tggttctgga tgttgggagt
      361 ggtacaggga tcctttccat gtttgctgcc aaagcagggg ccaagaaggt gtttgggatt
      421 gaatgttcca gtatttctga ctactcagag aagatcatta aggccaacca cctggacaat
      481 gtcattacca tatttaaggg caaagtggag gaggtggagc tgccagtgga gaaggtggac
      541 atcatcatca gcgagtggat gggctactgt ctgttctacg agtccatgct caacaccgtg
      601 atctttgcca gggacaagtg gttgaaacct ggagggctca tgtttccaga ccgggcagct
      661 ttgtacgtgg tagcaattga agacagacag tacaaggact tcaaaatcca ctggtgggag
      721 aacgtctatg gctttgacat gacttgcatc cgggatgttg ctatgaagga gcccctggtg
      781 gatatcgtgg acccaaagca agtggtgacc aatgcctgtt taataaagga agtggacatt
      841 tacactgtga agacggaaga gctgtctttt acatctgcct tctgcctgca gatacagcgc
      901 aacgactatg tccatgccct cgtcacctac tttaatattg aatttaccaa gtgccacaag
      961 aaaatgggtt tttctacagc ccctgatgcc ccctacactc actggaagca gactgtcttc
     1021 tacttagaag actacctcac tgttcgaaga ggggaggaaa tctacgggac catatccatg
     1081 aagccaaatg ccaaaaatgt gcgagacctc gatttcacag tagacttgga ttttaaggga
     1141 cagctgtgtg aaacatctgt atctaatgac tacaaaatgc gttagcacat gtgggaagct
     1201 gcggagagca atcgagaaga ggcactcact tcagtctgcc acgctgcccc aaggaatact
     1261 gttaagagga ccacactcga caaccagagc tttccactct gccttgaaga ttggcgaact
     1321 cgcccagggc tctcctgggc cccgctatca cagggagcct ccagctcctc ggttctgccc
     1381 ctggagccct tcacaaaggc tgtgttgttg ccttccgtgc tgtggctggg gctctgagga
     1441 gggaagcata cccatgtgcc cccattgtcc taaactgact ctctggatct tccaagtttt
     1501 gcatgctgca gacatctagg acaggttact tctgctagaa cctggagaca tacgtctttg
     1561 atagcataag ccagattttc tgtctgtgtg gtggtggtgt gtgtgagcgt gtgtgcgtgc
     1621 gtgcgtgcgc gcgcatgagt atacagcata tatattattt tacttgccca caaacatctg
     1681 tatatgcatg catatacaac taagtgggca tacttgggtg ttcattctga ggtgtgtgtg
     1741 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtgtg gtgggtgtgt gcgcctagaa
     1801 tctatattac tctcagagga ggttctgttg cttttggata ggaatttgtt tcgtgattag
     1861 ttttccccat cccgatccct taacagatgt tacacagcta tgaaacattc tgtgtactag
     1921 ctctggtctc gttttgacta gactgtggct ctgaatcctg agcacagtac catgggctct
     1981 gcgggcactc aataaacaca catgagaaag aa
//
LOCUS       NM_001393740            7016 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus SRC kinase signaling inhibitor 1 (Srcin1),
            transcript variant 1, mRNA.
ACCESSION   NM_001393740
VERSION     NM_001393740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7016)
  AUTHORS   Calipari,E.S., Godino,A., Salery,M., Damez-Werno,D.M., Cahill,M.E.,
            Werner,C.T., Gancarz,A.M., Peck,E.G., Jlayer,Z., Rabkin,J.,
            Landry,J.A., Smith,A.C.W., Defilippi,P., Kenny,P.J., Hurd,Y.L.,
            Neve,R.L., Dietz,D.M. and Nestler,E.J.
  TITLE     Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation
            Mediate Structural and Behavioral Adaptations During Withdrawal
            From Cocaine Self-Administration
  JOURNAL   J Neurosci 39 (29), 5634-5646 (2019)
   PUBMED   31092585
REFERENCE   2  (bases 1 to 7016)
  AUTHORS   Wang,W., Zhu,X., Du,X., Xu,A., Yuan,X., Zhan,Y., Liu,M. and Wang,S.
  TITLE     MiR-150 promotes angiogensis and proliferation of endothelial
            progenitor cells in deep venous thrombosis by targeting SRCIN1
  JOURNAL   Microvasc Res 123, 35-41 (2019)
   PUBMED   30315850
  REMARK    GeneRIF: Upregulation of miR-150 promoted angiogenesis and
            proliferation of endothelial progenitor cells by targeting SRCIN1
            in vitro and thrombus resolution in vivo.
REFERENCE   3  (bases 1 to 7016)
  AUTHORS   Li,M.Y., Miao,W.Y., Wu,Q.Z., He,S.J., Yan,G., Yang,Y., Liu,J.J.,
            Taketo,M.M. and Yu,X.
  TITLE     A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes
            in Stabilizing Spines and Functional Synapses in the Neocortex
  JOURNAL   Neuron 94 (6), 1155-1172 (2017)
   PUBMED   28641114
  REMARK    GeneRIF: Study demonstrates a critical role of presynaptic
            cadherin/catenin/p140Cap cell adhesion complexes in stabilizing
            functional synapses and spines in the developing neocortex.
REFERENCE   4  (bases 1 to 7016)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   5  (bases 1 to 7016)
  AUTHORS   Repetto,D., Camera,P., Melani,R., Morello,N., Russo,I.,
            Calcagno,E., Tomasoni,R., Bianchi,F., Berto,G., Giustetto,M.,
            Berardi,N., Pizzorusso,T., Matteoli,M., Di Stefano,P., Missler,M.,
            Turco,E., Di Cunto,F. and Defilippi,P.
  TITLE     p140Cap regulates memory and synaptic plasticity through
            Src-mediated and citron-N-mediated actin reorganization
  JOURNAL   J Neurosci 34 (4), 1542-1553 (2014)
   PUBMED   24453341
  REMARK    GeneRIF: we here demonstrate that p140Cap is a key element for both
            learning and synaptic plasticity
REFERENCE   6  (bases 1 to 7016)
  AUTHORS   Di Stefano,P., Damiano,L., Cabodi,S., Aramu,S., Tordella,L.,
            Praduroux,A., Piva,R., Cavallo,F., Forni,G., Silengo,L., Tarone,G.,
            Turco,E. and Defilippi,P.
  TITLE     p140Cap protein suppresses tumour cell properties, regulating Csk
            and Src kinase activity
  JOURNAL   EMBO J 26 (12), 2843-2855 (2007)
   PUBMED   17525734
REFERENCE   7  (bases 1 to 7016)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 7016)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   9  (bases 1 to 7016)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   10 (bases 1 to 7016)
  AUTHORS   Chin,L.S., Nugent,R.D., Raynor,M.C., Vavalle,J.P. and Li,L.
  TITLE     SNIP, a novel SNAP-25-interacting protein implicated in regulated
            exocytosis
  JOURNAL   J Biol Chem 275 (2), 1191-1200 (2000)
   PUBMED   10625663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2024 this sequence version replaced NM_001393740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000010.1  83066104-83066262   c
            160-461             JAXUCZ010000010.1  83042607-83042908   c
            462-560             JAXUCZ010000010.1  83039775-83039873   c
            561-584             JAXUCZ010000010.1  83033243-83033266   c
            585-780             JAXUCZ010000010.1  83027327-83027522   c
            781-979             JAXUCZ010000010.1  83026569-83026767   c
            980-1073            JAXUCZ010000010.1  83025923-83026016   c
            1074-1933           JAXUCZ010000010.1  83024668-83025527   c
            1934-2026           JAXUCZ010000010.1  83024142-83024234   c
            2027-2070           JAXUCZ010000010.1  83023875-83023918   c
            2071-2261           JAXUCZ010000010.1  83023438-83023628   c
            2262-2437           JAXUCZ010000010.1  83022133-83022308   c
            2438-2568           JAXUCZ010000010.1  83017044-83017174   c
            2569-2716           JAXUCZ010000010.1  83016795-83016942   c
            2717-2963           JAXUCZ010000010.1  83016285-83016531   c
            2964-3198           JAXUCZ010000010.1  83015612-83015846   c
            3199-3353           JAXUCZ010000010.1  83013471-83013625   c
            3354-3506           JAXUCZ010000010.1  83013106-83013258   c
            3507-3653           JAXUCZ010000010.1  83008702-83008848   c
            3654-7016           JAXUCZ010000010.1  82999295-83002657   c
FEATURES             Location/Qualifiers
     source          1..7016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..7016
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
     exon            1..159
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3788
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p130Cas-associated protein; SNAP25-interacting protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1 isoform 1"
                     /protein_id="NP_001380669.1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
                     /translation="MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRF
                     SNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQ
                     DRMREQVGGWTVDPVCLLSSLCSHLHGDSTPSGAGQPAQQPNYWSFKTRSSRHTQGAQ
                     PGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLF
                     LQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYE
                     LEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPA
                     SHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTS
                     QGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGD
                     PFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSP
                     QKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGAS
                     TAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGS
                     EPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQ
                     MQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDP
                     LQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALV
                     LKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLA
                     QIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGT
                     PLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQA
                     ELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRT
                     EKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKL
                     RRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQ
                     GPAGSPDKGKHGKQRTEYMRIQAQQQATKPSKEMSGPNETSSPVSEKPSGSRTSIPVL
                     TSFGARNSSISF"
     misc_feature    789..>1028
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    789..>1028
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="Actin interacting protein 3; Region: AIP3;
                     pfam03915"
                     /db_xref="CDD:427585"
     misc_feature    <2292..2756
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    <2292..2756
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            160..461
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            462..560
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            561..584
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            585..780
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            781..979
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1933
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2026
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2070
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2261
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2437
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2568
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2716
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2963
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3198
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3353
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3506
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3653
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..7016
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggccc gcgcccccgg cccgcccgcc tggcaccgcg ccccggggct ggggccgagc
       61 gaggagcccg cgaggcggcg agagggcgag cgccaggcag gccggcccgg ggcccccgcc
      121 ccccgcgccc ccgcccgatg gggaacgctc cgtcccaaga tccggagcgg agcagccccc
      181 ccatgctgtc tgccgacgat gccgaatatc ctcgggagta ccggaccctg gggggtgggg
      241 gcagcggggg cagcgggggc cggcgcttct ccaacgtggg gctggtgcac acctccgagc
      301 ggcggcacac ggtgatcgct gcccagagcc tggaggccct cagcgggctc cagaaggccg
      361 atgctgaccg caagcgagat gcgtttatgg accacctgaa gagcaagtac ccccagcatg
      421 ccctggccct tcgaggtcag caggacagga tgagagagca ggtcggcggc tggaccgtgg
      481 accctgtgtg cctcctcagc tccctctgtt cccacctcca cggcgactcc accccctcag
      541 gggctggcca gcctgcccag caaccaaact actggagttt caagacccgc agctcgcgcc
      601 atactcaggg agcccagcca gggctggcag accaggcagc caagctgtcc tacgcctcgg
      661 ctgagtcgct ggagacaatg tccgaggccg agctgcccct gggcttcagc aggatgaatc
      721 gcttccgaca gagcttgcct ctctcccgct ctgccagcca gaccaagctg cgctcaccag
      781 gagtcctgtt cctgcagttc ggggaggaga cgcgacgtgt acacatcacg catgaggtca
      841 gcagcctgga cacgctgcac gcactcatcg cgcacatgtt cccgcagaag ctcaccatgg
      901 gcatgcttaa gtcgcccaac accgccatcc tcatcaagga cgaggctcgc aacgtcttct
      961 acgagctgga agacgtccgg gatatccagg accggagtat catcaagatc tataggaagg
     1021 agccactgta tgccgctttt cctggctcgc acctcaccaa cggtgacctc cggagagaga
     1081 tggtttacgc atcgcgggag tcgtcgccca cgcggcgcct caacaacctg tcgcccgcat
     1141 cgcacctagc atctagctcc ccgcctccag ggctgccatc cgggctgcct tcgggactgc
     1201 catcgggctc gccctcgcgt tcacgcctct cgtatgctgg gggccggccg ccctcttacg
     1261 ccggcagccc ggtacaccac gcggctgagc gactgggagg cgccccgacc agccagggcg
     1321 tgagccccag ccccagcgcc atcctggagc ggcgcgacgt gaagccagat gaggatctgg
     1381 cgggcaaggc gggcggcatg gtgctggtga agggcgaggg cctctatgcc gatccctacg
     1441 ggctgctgca cgagggccgc ttgagcctgg ccgccgcagc aggagacccg ttcgcatacc
     1501 cgggcgcggg cggcttgtac aagcggggtt ctgtgcgctc gctcagcacc tactcggccg
     1561 ctgcgctgca gtccgacctg gaggactcgc tgtacaaggc gggcgccggc ggcccgctct
     1621 acggagacgg ctatggcttc cgtctgccgc cttcgtcccc gcagaaacta gccgacgtct
     1681 cagcgccctc cgggggacct ccgccaccgc acagccccta ctctgggccg cccagccgcg
     1741 gctcgccggt gcgccagtcg ttccgtaaag attctggttc ctcgtcggtc tttgctgaga
     1801 gtcctggagg caaagcccgc agcaccgggg cttccacggc cggagcacca ccttctgaac
     1861 tcttccctgg acctggagag cgctccctcg tagggttcgg gccgccggtg ccagccaagg
     1921 acacagagac cagggagcgt atggaggcca tggagaagca gattgccagc ctcactgggc
     1981 tagtacagag tgctttactg cgaggctcgg agccggagac cccaagtgag aagattgaag
     2041 gctccaatgg agcagccacc ccctcagcac cagtgtgtgg gtcaggcagt aggagtagcg
     2101 gggccactcc agtgtcgggc cctcccccac ccgcggtcag cagcacccct gcagggcagc
     2161 ccactgctgt cagccggctg caaatgcaga tgcatctgcg tggcctacag aacagcgcta
     2221 gcgacctgcg tggccagctt cagcagttgc ggaagctcca gctccagaac caggagtcgg
     2281 tgcgcgcgct gctgaagcgc accgaggcgg agctgagcat gcgcgtgtcg gaggcggcgc
     2341 ggcggcagga ggacccgctg cagcggcagc gcaccctggt ggaagaggag cgtttgcgtt
     2401 acctcaacga cgaggagctc attacacagc agctcaatga cctggagaag tcagtggaga
     2461 agatccagag ggatgtggcc cataaccacc ggctggtgcc tggtcctgag ttggaagaga
     2521 aggctctggt gctgaaacag cttggggaga cgctgacgga actcaaggct catttcccag
     2581 gcctgcagag taagatgcgg gtagtgctgc gtgtagaggt ggaggcagtc aagtttctga
     2641 aggaggaacc tcaacgcctc gacgggcttc tcaagcgctg ccgggtggtc actgacacgc
     2701 tggcccagat ccgaaggcaa gtggatgagg gtgtgtggcc tccccccaac aatctcctga
     2761 accagtcccc caagaaggtg gcagccgaaa cagacttcag caaaggcctg gattttgaga
     2821 taccaccccc gagtcctcca ctgaatctcc acgagctgag cgggcctgcg gaaggcaccc
     2881 cgcttacccc aaaaagcggc aaccctacca aaggcctgga tgctccgagc aagagaaaca
     2941 tggacaaagc tgtgtctgtc gaggctgcag agagagactg ggaagagaag cgggccgccc
     3001 tgacccagta cagcgccaag gacatcaacc ggctgctgga ggaaacccaa gctgagctgc
     3061 tcaaggctat ccccgacctg gactgtgcca gcaagaccca cccaggccct actcccactc
     3121 cagaccacaa gccccctaag gcaccccatg gtcagaaggc tgctccccgg acagagccca
     3181 gtgggagaag aggatcagat gagctcacag tgccccgata ccgcacagag aagccctcca
     3241 agtcgccccc gccaccccct ccccgccgga gcttcccttc ctcgcacggc ctgaccacca
     3301 ctcgcaccgg agaagtggtg gtcaccagta agaaagactc agtcttcatc aagaaggctg
     3361 aatctgagga gctggagatc cagaagcctc aggtgaagct gcgtcgcgct gtgtctgagg
     3421 tggtccgccc cgcgtccaca ccgcccatta tggcctcggc catcaaggat gaagacgatg
     3481 aggaacgcat cattgctgag ctggagagtg gtggtggcag tgtgccaccc atgaaggtgg
     3541 tgactcccgg agcctctcgg ctgaaggcgg cccagggtcc agcaggcagc cctgataaag
     3601 gcaaacacgg caagcaacga acggaataca tgaggatcca ggcccagcag caggccacta
     3661 aaccatctaa agagatgagc ggtccgaatg agacctcaag ccccgtctca gaaaaaccct
     3721 ctggttccag aacctccatc cctgtattga cttcctttgg ggcaaggaat tcttccatct
     3781 ccttctagaa gcccctcatg ccaccacccc agcctgcccc tcctttattc ctgccatcgt
     3841 ccctcctttc atgctctacc ctcttcactc tctcgcctga agggttgcag ggggcatggc
     3901 cctctgctct ctcatctcct cttggtgttt ttggtttttt taagcgattt ccttttaatt
     3961 atcttccttt tcctttttct ttttttaaag agtaaaagag aaagctaaaa accaaacaca
     4021 ccaacgtccc ctcacttcct gttccccagc gggcctctgc tccgcccact tcctgtcatt
     4081 ttcccccttc tgctccgccc acttcctgtc atcttcttcc cctctgctct ttcacccttt
     4141 ccccccaccc ccaagtccat ccaaagttcc cacctcccct aacttcccaa gaacacttgg
     4201 aacaaactct gagccacgga gacttggagc ggagcgagac cccctcccat ttactgggtt
     4261 ccttcctgga ggaacaaatg gacaaggact gactcagcgt caggctggac aatggacaag
     4321 ggagaccctg gccttggaga cgccccactg tctgtccagc cttcgaagag acagaactct
     4381 gctgctggcc tgtggttttt ctttcgaacc agggtgggcc tggaagcagg cctagctgga
     4441 ggggattccc agagaagagg ccaaggctgg gtgtgaggag ggaagggggt gggggggaca
     4501 ctaggtgcca ggggagaagc tggctcactg ctgctcagtg tccggctggt gctagcaaca
     4561 aatagaagga ggtccccaag acacctgtta tggagggtgc ttctggggac agcctgcccc
     4621 tggggttctg ccttgggaga gggcaaccct gagaggggca actggtactt ttagttccct
     4681 aatttagcac tttaaatgcc attaacttat tttgtggggg tggggtgggg aagatggaag
     4741 ggcctagaac tatgtttgga gggtgggaag ggtctgcttt gagggataca gggagaaggg
     4801 ttgggtgggt gcagtaaagt ctctgacccc tagggggagc aacttgacct tcagccagcc
     4861 tctatgattc gagggttttc agggaagggg tgagatgtga cttgcctgta gggatctggt
     4921 gaccactcgt caggtgtttg agggtcccca aggcagaaga gccagctagt actccagtct
     4981 ggataccttg caggggtcct gcacagggca gactgacttt tgcgtgggtc caggagtcaa
     5041 agggagaggc tgacttggtt ctggcctggc ccccagcaag tacagagggg ccagagcgaa
     5101 aaggattacg gagagggctg gaagggtgga gggggtcccc tttggagcac aaagcagagt
     5161 aagcacagag atgtggtctt gggactagtc ccacagtaag cacagagagg aaccattgaa
     5221 gggacagaac cccaagaccc tggagcccag caggggagag ccagtggcag ctgttgacgg
     5281 tttggggagg gagggaaaac tgggttgtgt ttcttttctt tgatttcgtt cgtttttatt
     5341 tctttctctt tgttttattg gtttgctctt gttttctagc tttgaatcat ttttgtacta
     5401 aggcaagcaa gcctttttga aaaataacaa aagaagaaga aaaaaaaatc cctcccagaa
     5461 aaaaacaaaa cgaaaaaaaa aaaaaaaaca aaaaacaaaa taaaaaaaac caaaaaaagc
     5521 cctaaaaaat agaaaaaaaa ggacctcaca atgatgcaat tacttttaat tgcaagtaac
     5581 tctttacatt taagtgaagt gtcttaacat tttatattgt tttaaaaata tatttacata
     5641 ttatatatat ataatatacg taatataaat atatataaat atttaaaaaa gaaaaaaaaa
     5701 aaaaagaaaa ccacagcaca ctctccctgg ccgctgtctg gcaagggagg ggctggggac
     5761 aggcgtatgg cctggtgtcc atagtccccg tgaagcagtt tggtttgatt tggctgtaca
     5821 gagacccctg gcttgggagg ggagggggag ggcccctcca ctccatttct ctttgcttgc
     5881 tactctttgc ttgcccccac acccgctcag ccctgtgacc tgagtctgcg cccctccgtc
     5941 attgtcctga gttgagtgtc cttcgtggag agaggggatg ccggaggaag tgaccatcca
     6001 cgtaggggct gccccacgag ctcaggcaag gcccgtggga tttgcgtagt tctagttctt
     6061 cgatttggtt cctgcgcacg tgtgtcctgg aaggcatttg tgtgggtttg tgtgcacgtg
     6121 tgtgtgcacg ctggcacaag cctacataac ttgtgtgtgc acatgcatgg attgtgtgtg
     6181 cataggccaa acttaatatt gtatgtggaa gccttgtaca tgtatgtgaa catcacctgc
     6241 ctggacatca cagcatgatt gtgtgaggag agccttggga gtaagaacat gtgtaatgtg
     6301 tgtgtggacg tgcctggctg ttcttgtgag gcccacatat ggatgggtac agtaacctta
     6361 gctgtgggta tggttgtgca ggcaggtgtg tgagagggcc tctgtgtgtg tgtgagtact
     6421 cgtgtgcatg tgtgtgcgcg cgcgttccat catccctgca ccactcgccc ggctcccctc
     6481 ccaagctccg cccccacccg ccttctcaaa gcccacagca cgtcaatccc cgccccctgg
     6541 cccccaggcc cccagctgca tgcgcctcgc cgctgtccat cagtgtgtgc ttgacaagag
     6601 aaactgccac atcggggacc ctgtacctgg tcccctcacc cctgcccgct gtgctgtgtt
     6661 actcgcatgg gggggttctc tctgccccct tccacaatat actgtttccc taggggcctc
     6721 ggggccaagg ctttgagtga ggtcccaagt ggggtccccc aaggccagcc cggctccaca
     6781 cccacccgtc caccccgtag ggcctgtgtt ggtgtagaag tgatggcttc tgtggatatt
     6841 gtgacctctg tcagtgtaac ttgacaattt ttaaatggaa agggttgctg tgttttctgt
     6901 ctctttttta atgtccttct tttcttccct acctcccgct ctcttccctt tccttttggt
     6961 ttttctagcc gagtgttggg gctttaataa aacttgtttc ctttttctct ccggga
//
LOCUS       NM_001427275           11531 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus FRY like transcription coactivator (Fryl), mRNA.
ACCESSION   NM_001427275
VERSION     NM_001427275.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11531)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   2  (bases 1 to 11531)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000014.1  35310656-35310886
            232-407             JAXUCZ010000014.1  35348233-35348408
            408-535             JAXUCZ010000014.1  35371423-35371550
            536-735             JAXUCZ010000014.1  35421921-35422120
            736-789             JAXUCZ010000014.1  35432108-35432161
            790-929             JAXUCZ010000014.1  35435040-35435179
            930-1026            JAXUCZ010000014.1  35435903-35435999
            1027-1106           JAXUCZ010000014.1  35441876-35441955
            1107-1187           JAXUCZ010000014.1  35442644-35442724
            1188-1356           JAXUCZ010000014.1  35444881-35445049
            1357-1449           JAXUCZ010000014.1  35445277-35445369
            1450-1548           JAXUCZ010000014.1  35447225-35447323
            1549-1650           JAXUCZ010000014.1  35448487-35448588
            1651-1754           JAXUCZ010000014.1  35454561-35454664
            1755-1863           JAXUCZ010000014.1  35454932-35455040
            1864-1950           JAXUCZ010000014.1  35456707-35456793
            1951-2122           JAXUCZ010000014.1  35458637-35458808
            2123-2255           JAXUCZ010000014.1  35459193-35459325
            2256-2363           JAXUCZ010000014.1  35462702-35462809
            2364-2601           JAXUCZ010000014.1  35466264-35466501
            2602-2787           JAXUCZ010000014.1  35467798-35467983
            2788-2874           JAXUCZ010000014.1  35468230-35468316
            2875-3143           JAXUCZ010000014.1  35469646-35469914
            3144-3339           JAXUCZ010000014.1  35470538-35470733
            3340-3464           JAXUCZ010000014.1  35471696-35471820
            3465-3522           JAXUCZ010000014.1  35472597-35472654
            3523-3614           JAXUCZ010000014.1  35474816-35474907
            3615-3787           JAXUCZ010000014.1  35477666-35477838
            3788-3948           JAXUCZ010000014.1  35479673-35479833
            3949-4059           JAXUCZ010000014.1  35480437-35480547
            4060-4214           JAXUCZ010000014.1  35481814-35481968
            4215-4314           JAXUCZ010000014.1  35482252-35482351
            4315-4483           JAXUCZ010000014.1  35483415-35483583
            4484-4740           JAXUCZ010000014.1  35485500-35485756
            4741-4881           JAXUCZ010000014.1  35486078-35486218
            4882-5050           JAXUCZ010000014.1  35490692-35490860
            5051-5135           JAXUCZ010000014.1  35493505-35493589
            5136-5248           JAXUCZ010000014.1  35494239-35494351
            5249-5399           JAXUCZ010000014.1  35495425-35495575
            5400-5503           JAXUCZ010000014.1  35496213-35496316
            5504-5689           JAXUCZ010000014.1  35497956-35498141
            5690-5894           JAXUCZ010000014.1  35499533-35499737
            5895-6016           JAXUCZ010000014.1  35501011-35501132
            6017-6207           JAXUCZ010000014.1  35501750-35501940
            6208-6302           JAXUCZ010000014.1  35503300-35503394
            6303-6910           JAXUCZ010000014.1  35504797-35505404
            6911-7008           JAXUCZ010000014.1  35505771-35505868
            7009-7179           JAXUCZ010000014.1  35510922-35511092
            7180-7320           JAXUCZ010000014.1  35512610-35512750
            7321-7518           JAXUCZ010000014.1  35514744-35514941
            7519-7680           JAXUCZ010000014.1  35515373-35515534
            7681-7755           JAXUCZ010000014.1  35515646-35515720
            7756-7932           JAXUCZ010000014.1  35516011-35516187
            7933-8136           JAXUCZ010000014.1  35519592-35519795
            8137-8301           JAXUCZ010000014.1  35521875-35522039
            8302-8549           JAXUCZ010000014.1  35528017-35528264
            8550-8757           JAXUCZ010000014.1  35530565-35530772
            8758-8907           JAXUCZ010000014.1  35532016-35532165
            8908-9006           JAXUCZ010000014.1  35532908-35533006
            9007-9075           JAXUCZ010000014.1  35538409-35538477
            9076-9186           JAXUCZ010000014.1  35541508-35541618
            9187-9377           JAXUCZ010000014.1  35542652-35542842
            9378-11531          JAXUCZ010000014.1  35542994-35545147
FEATURES             Location/Qualifiers
     source          1..11531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..11531
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="FRY like transcription coactivator"
                     /db_xref="GeneID:364144"
                     /db_xref="RGD:1311309"
     exon            1..231
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            232..407
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            408..535
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    484..486
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="upstream in-frame stop codon"
     exon            536..735
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..9636
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="FRY-like"
                     /codon_start=1
                     /product="protein furry homolog-like"
                     /protein_id="NP_001414204.1"
                     /db_xref="GeneID:364144"
                     /db_xref="RGD:1311309"
                     /translation="MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLL
                     SRSLQRGEDLQFDQLISSMSSVAEHCLPSLLRTLFDWYRRQNGTDDESYGYRPRSSTK
                     SKGDEQHRERDYLLERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFK
                     HKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVRKKFVTELKELRQKEQSPHVVQS
                     IISLIMGMKFFRVMMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV
                     AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWH
                     IFLQNCLSHLKNKDPKMSRVALESLYRLLWVYVIRIKCESNTVTQSRLMSIVSALFPK
                     GSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVGKSAKTFTINPERMNIG
                     LRVFLVIADSLQQKDGDPPMPTTGVILPSGNTLRVKKIFLNKTLTDEEAKVIGMSVYY
                     PQVRRALDSILRHLDKEVGRPMCMTSVQMSNKEPEDMITGERKPKIDLFRTCIAAIPR
                     LIPDGMSRTDLIELLARLTIHMDEELRALAFNTLQALMLDFPDWREDVLSGFVYFIVR
                     EVTDVHPTLLDNAVKMLVQLINQWKQAAQMYNRTQDSQQSISNGGPHPPPLERSLYST
                     VFHVVEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDEELAIDVMDRLSPS
                     ILESFIHLTGADQTTLLYCPSSVDLQTLADWNSSPISHQFDVISPSHIWIFAHVTQGQ
                     DPWIISLSSFLKQENLPKHCSTAVSYAWMFAYTRLQLLSPQVDINSPINAKKVSTTTS
                     SDSYVGLWRNYLILCCSAAASPSPSAPAGSVRCSPPETLASTPDSGYSIDSKIVGIPS
                     PSSLFKHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEALERRPENMK
                     RRRRRDILRVQLVRIFELLADAGVISHSASGGLDNETHFLNNTLLEYVDLTRQLLEAE
                     NEKDSDTLKDIRCHFSALVANIIQNVPVHQRRSIFPQQSLRHSLFMLFSHWAGPFSIM
                     FTPLDRYSDRNMQINRHQYCALKAMSAVLCCGPVADNVGLSSDGYLYKWLDNILDSLD
                     KKVHQLGCEAVTLLLELNPDQSSLMYWAVDRCYTGSRRVAAGCFRAIANVFQNRDYQC
                     DTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKMFRYAHKLEVQRTDGVLSQLSPLP
                     HLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTAHPAGRQAMLHYLLPWMNNIELV
                     DVRPLPSGRRQDEEDGSLKDRELMVTSRRWLRGEGWGSPQATAMVLNNLMYMTAKYGD
                     ELAWSEVENVWTTLADGWPKNLKIILHFLISICGVNSEPSLLPYVKKVIVYLGRDKTM
                     QLLEELVSELQLTDPVSSGVTHMDNPPYYRITSGCKIPSVTSGTTSSSNTMVAPTDGN
                     PDSKALKENFEESFVHLDIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDSMPLYS
                     NWRLKVMEHNQGEPLPFPPAGGCWSPLVDYVPETASPGLPLHRCSIAVILLTDLIIDH
                     SVKVEWGSYLHLLLHAVFIGFDHCHPEVYEHCKRLLLHLLIVMGPNSNIRTVASVLLR
                     NKEFNEPRVLTVKPTAHSDYTFTAGINDFTPDYQPSPMTDSGLSSSSTSSSISLGNNS
                     AAISHLQATLLGEVDLSVEQDGKVKTLMEFITSRKRGPLWNHEDVSSKNPSIKSADQL
                     TTFLKHVVSVFKQSNAEGIHLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSA
                     NTLSDVLSRLVETVGDPGEDAQGFVIELLLTLESAIDTLAETMKHYDLLSALSQTSYH
                     DPVMGNKYAANRKSTGQLNLSTSPINSSSHLGCNGDTRSNSLRLSLVGDRRGDRRRSN
                     TLDITDGRTNHGGSLVRTRSLSSLREKGVYDTQPPTEPGNLMATIFWIATSLLESDYE
                     YEYLLALRLLSKLLTHLPLDKSESREKIESVQSKLKWSNFPGLQQLFLKGFTSVSTQE
                     MTVYLLSQLISVSKHTLVDPSQLSGFPLNILCLLPHLIQHFDNPTQFCKETASRIAKV
                     CAEEKCPTLVNLAHMMSLYSTHTYSRDCANWINVVCRYLHDSFSEATFSLVTYLAELL
                     EKGLASMQQSLLQIIYSLLSHVDLSAAPAKQFNLEITKTIGKYVQSPYWKEALNILKL
                     VVSRSASLVVPNDIPKAYGVDVGSPEISFAKIFNNVSKELPGKTLDFHFDISETPIIG
                     NKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLMS
                     VLSLCGPESGLPKNPSVIFSSNEDLEVGDQQTSLISTTEDIIQEEEVAVEDSSSEQQF
                     GVFKDFDFLDVELEDAEGESMDNFNWGVRRRSLDSIDKGDTPSLQECPCSSSTPSLTL
                     TNQEDTDESSEEEAALTASQILSRTQMLNSDCVPDDLMPDHQDLLQSQDSASSNTTED
                     VLQIRDETPSLEACLDNASCQLPEDTSSVLKEEHVTAFEDEGPYLIQDQQDPLVCRGI
                     LDLEETDMPEPLAPESYPESVCEEDVTLALKELDERCEEEEADFSGLSSQEEDEQDGF
                     PEVQTSPLPTPFLSAIIAAFQPMAYEDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRL
                     FQTIQRKFGEITNEAVGFLGKSLQRIGTKFKSSLEVMMTCSECPTVFVDAETLMACGL
                     LETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTFGANEDIDRINTNAHELELCRRL
                     YRLHFQLLLLFQAYCKLINQVNAIKNEAEVINMSEELTQLEGILKEAEAASENEETDI
                     SKAAQTTIETAIHSLIETLKNKEFVSAVAQVKAFRTLWPSDIFGSCDDDPVQTLLHIY
                     FHHQTLGQTGSFAVIGSNLDMSEANCKLMELNLEIRESLRMVQSHPLLAQAKPVGKTA
                     SAGF"
     misc_feature    964..2562
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis N-terminal; Region: MOR2-PAG1_N;
                     pfam14222"
                     /db_xref="CDD:464107"
     misc_feature    964..2562
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis N-terminal; Region: MOR2-PAG1_N;
                     pfam14222"
                     /db_xref="CDD:464107"
     misc_feature    2674..6192
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis central region; Region:
                     MOR2-PAG1_mid; pfam14228"
                     /db_xref="CDD:433790"
     misc_feature    2674..6192
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis central region; Region:
                     MOR2-PAG1_mid; pfam14228"
                     /db_xref="CDD:433790"
     misc_feature    6616..7377
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis C-terminal; Region: MOR2-PAG1_C;
                     pfam14225"
                     /db_xref="CDD:464109"
     misc_feature    6616..7377
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Cell morphogenesis C-terminal; Region: MOR2-PAG1_C;
                     pfam14225"
                     /db_xref="CDD:464109"
     misc_feature    7465..9633
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Furry protein C-terminal; Region: Fry_C; pfam19421"
                     /db_xref="CDD:466072"
     misc_feature    7465..9633
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /note="Furry protein C-terminal; Region: Fry_C; pfam19421"
                     /db_xref="CDD:466072"
     exon            736..789
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            790..929
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1026
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1106
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1187
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1356
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1449
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1548
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1650
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1754
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1863
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1950
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2122
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2255
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2363
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2601
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2787
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2874
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3143
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3339
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3464
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3522
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3614
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3787
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3948
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4059
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4214
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4314
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4483
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4740
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4881
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5050
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5135
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5248
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5399
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5503
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5504..5689
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5690..5894
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..6016
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            6017..6207
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            6208..6302
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            6303..6910
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            6911..7008
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7009..7179
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7180..7320
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7321..7518
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7519..7680
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7681..7755
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7756..7932
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            7933..8136
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            8137..8301
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            8302..8549
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            8550..8757
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            8758..8907
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            8908..9006
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            9007..9075
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            9076..9186
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            9187..9377
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
     exon            9378..11531
                     /gene="Fryl"
                     /gene_synonym="RGD1311309"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaagggg tgggcagagc tcgcagcacc gccgggcgcc cgtcgggctc tgggagagac
       61 agaaatccgg ttaaaatcag agtcggaggg aggtttaacc acggatcggt cccgatcgga
      121 ttattcctta aaggggacgc gccattgtca aagagaacgg agcctggggc ccgagggcgg
      181 ggaccggcgg cgcttggagg agcgaggcag ctgcacggga ctggggacct gccttcgaca
      241 ttccacactc tgctacatat ctggagtcac cctgctgctt tttcccagcg cgccctcttc
      301 agtgcctgtg aagttcaagc cccaggctgg agaagcttct agatggatcc tttccaaatt
      361 cggtgtcttt tctaccaacg ctgtgcctca ccctcagtct ctaagtgaga cgaagccatt
      421 tatttgaatc tgggcaatta ccctctaaat gcttaattct tcaaactgcg caagcgtcat
      481 gcatgactag atgctccatg tcaccacgga gaacttagtc tggagcggca ctacgcttca
      541 gcaccagtca gcaaagtgaa taagttctgt gccacttcca acttccattc cgctctggga
      601 agaaagagca ccatcatgtc aaacatcacg attgaccccg atgtcaagcc tggtgaatac
      661 gtcatcaaga gtctctttgc ggagtttgct gtgcaagcag aaaagaaaat tgaagttgta
      721 atggccgaac ccttggaaaa gctgttatcc agatctcttc agaggggtga agatctgcag
      781 tttgaccagt tgataagctc tatgagctcc gtagccgagc actgtctccc ttccttactc
      841 cgaaccttgt ttgactggta ccgacgccag aacgggactg acgatgaatc ctacgggtac
      901 aggccgaggt ctagcacaaa gtctaaggga gacgagcagc accgtgagag agattacctc
      961 ctggagcggc gggacttagc tgtagacttc attttctgtt tagtcttggt agaagttcta
     1021 aagcagattc ctgtccaccc tgtacccgac cccttagttc atgaggttct aaacctagct
     1081 tttaagcact ttaaacacaa ggaaggatat tcagggacca acacggggaa cgtgcacatc
     1141 attgcggatc tatatgcaga ggtgattggc gtgctcgccc agtcgaagtt ccaggcggta
     1201 aggaagaagt tcgtgactga gttgaaagag ctgcgacaga aggagcagag cccgcacgtg
     1261 gtccagagca tcatcagctt gatcatgggg atgaagttct tccgagtgat gatgtaccct
     1321 gtggaagact tcgaagcctc gtttcagttc atgcaggaat gcgctcagta tttcttagaa
     1381 gtgaaagaca aggatataaa acatgcactt gctggtttat ttgtggagat ccttatcccc
     1441 gtagccgctg ctgttaaaaa tgaagtcaat gtcccctgtt tgaaaaattt tgtggagatg
     1501 ctgtatcaga ctacatttga actaagttcc agaaagaagc attcactggc tttgtaccca
     1561 ctaattacct gtcttttatg tgtcagtcaa aaacagtttt ttttaaataa ctggcatatt
     1621 ttcctacaaa actgtttgtc acatttaaag aataaagacc ctaaaatgtc tcgagttgca
     1681 ctggagtctt tgtacagact gttgtgggtt tatgtaatta gaataaaatg tgagagcaat
     1741 actgtaacac aaagtcgcct gatgagcata gtgtcagctc ttttcccgaa aggctcccga
     1801 agcgtggtcc cccgagacac ccctctcaac atctttgtga agatcatcca gttcattgct
     1861 caggaacgtt tggattttgc aatgaaagaa ataatatttg atcttctgag tgttggaaaa
     1921 tctgctaaaa ctttcaccat taatccagag aggatgaaca ttggcctcag agtcttcctc
     1981 gtcatcgctg acagcctgca gcagaaagat ggtgaccctc ccatgcccac cacaggagtc
     2041 attcttccct caggaaacac tcttcgtgtg aagaagattt ttctcaataa aaccttgaca
     2101 gatgaagagg caaaagtcat aggaatgtca gtgtactatc ctcaagtaag gagagcgtta
     2161 gacagcattc tccggcatct ggacaaagag gttgggagac caatgtgtat gaccagtgtg
     2221 cagatgtcca acaaagagcc agaagacatg attacggggg aaaggaaacc caaaatcgat
     2281 ttgtttagaa cttgcattgc tgccattccg aggttgattc ccgatggtat gagcagaact
     2341 gacctcattg agctgttagc aaggctcact atccacatgg atgaggaact acgggcgctg
     2401 gctttcaaca ccctgcaggc actgatgctt gatttcccag attggcggga ggatgttctt
     2461 tcaggatttg tatattttat tgttcgtgaa gtgactgatg tccaccccac ccttcttgat
     2521 aatgctgtaa agatgttggt acaattaata aatcagtgga agcaggcagc tcagatgtac
     2581 aacaggaccc aggactccca gcagagcatc tctaatggag gtcctcaccc ccctcctctg
     2641 gaaaggagcc tatattccac tgtgttccat gtggtcgaag gctttgcgct ggtcatcctc
     2701 tgtagcagcc gtcccgccac aagaaggctg gctgtcagtg tccttagaga gatacgggct
     2761 ttgtttgcac ttttggaggt ccctaagggt gatgaggagt tagccattga tgtgatggac
     2821 aggctgagcc catccattct ggagagcttc atacatctca cgggggccga ccagactact
     2881 ttgctgtatt gcccgagctc cgtagacctg cagacattag cagattggaa ctcttctccc
     2941 atcagccacc agtttgatgt gatcagcccc tcacacattt ggatatttgc acatgtgacc
     3001 caaggccaag acccatggat tataagcctc tccagttttc taaagcaaga aaatcttccg
     3061 aagcactgct ccacagctgt gagctatgcg tggatgttcg cgtacacgag gctgcagcta
     3121 ttgtcccccc aggttgatat aaatagcccc atcaatgcta agaaagtaag caccaccacg
     3181 agcagtgact cgtacgttgg cctgtggaga aactacctga ttctctgctg cagcgcggcc
     3241 gcctccccgt ccccttcagc acccgcaggc tccgtgagat gctctcctcc cgagacgctg
     3301 gcgtccaccc ctgacagtgg ctacagcatc gattccaaga ttgttggcat cccgtcccct
     3361 tcctccctgt ttaagcacat agttccaatg atgcgctccg agagcatgga aatcacggag
     3421 tccctcgttc taggtctcgg caggaccaac ccgggagcct tcagagaatt aatagaggag
     3481 ttgcacccca taattaaaga agcacttgaa agaaggccag agaatatgaa gcggcgcagg
     3541 cgtcgagaca ttttacgagt acaactggta cggatatttg aactgttggc ggatgctggc
     3601 gtcattagtc acagtgcaag cggcggcctg gataacgaaa ctcacttcct caacaacact
     3661 ctgttggagt acgtagattt aacccgacaa cttctggagg cagagaatga gaaggactcc
     3721 gacacactga aggatatccg atgccatttc agtgccttag tggcgaatat cattcagaac
     3781 gttccggtgc accagagaag aagtatcttt ccacaacaaa gccttcgtca cagtctgttt
     3841 atgctgttca gccactgggc ggggcccttt agcatcatgt ttacgccctt ggacagatac
     3901 agtgatagga atatgcaaat caacagacac caatactgtg cattaaaggc tatgtctgct
     3961 gtactgtgtt gtggccctgt tgcagataac gtgggactgt catctgatgg ctatttgtac
     4021 aaatggctgg ataacatttt ggactctctg gataaaaagg ttcaccaatt aggctgtgaa
     4081 gcagtcacat tgctgctgga gctgaaccct gatcagagca gcctgatgta ctgggccgtg
     4141 gaccgatgct acacgggctc ccggagggta gctgccggct gcttcagagc cattgccaac
     4201 gtgttccaga acagggatta tcagtgtgac acggtgatgc tcctaaatct gatactgttc
     4261 aaagcagctg actcttctag aagcatctat gaagttgcta tgcaactctt gcagatcctg
     4321 gaaccgaaga tgtttcgcta tgctcacaaa ctggaggttc agagaacgga tggagtcctc
     4381 agccagctgt ccccgctgcc acacctgtat tccgtttctt attaccagtt gtctgaggaa
     4441 ctagccaggg catatccaga gctcacgctt gccatattct cagagatcag ccagcggatc
     4501 cagacagctc accccgcggg gcggcaggca atgctacact atctcctgcc ctggatgaac
     4561 aacatcgagc tggtggacgt cagacctctg ccctcaggga ggcggcagga tgaagaagat
     4621 ggctccctga aagacagaga gctcatggtg accagtcggc gctggctgag aggagaaggc
     4681 tgggggtccc cacaggccac cgccatggtg ttgaacaatc tcatgtatat gacggcgaag
     4741 tacggcgatg agctggcctg gtcggaggta gagaacgtgt ggaccaccct tgcagacggc
     4801 tggccaaaga acctgaaaat tattttgcac tttttgatca gcatttgcgg ggtgaacagc
     4861 gaaccaagcc tcttgcctta cgtgaagaaa gtgatcgttt atctgggtag agacaaaacc
     4921 atgcagctgc tagaagagct ggtgagcgag cttcagctca cagacccggt cagctcgggc
     4981 gtgacgcaca tggataaccc tccctactac cgcatcactt ctggctgtaa aatcccttcc
     5041 gtcacctcag gaactacttc cagtagcaat acaatggtag ctcccacaga tggcaacccc
     5101 gacagtaagg ccctaaagga gaactttgaa gagagctttg tgcacctgga catctatggt
     5161 gggctgaaca gtcacttaaa ccggcagcac cacagactgg agtctcgata cagcagcagc
     5221 tccggagggt cttatgaaga ggaaaaaagt gattcgatgc cactttattc taattggcgc
     5281 ctgaaagtga tggagcataa ccaaggagag ccactgccct tcccgccagc tggaggctgc
     5341 tggtcaccac tggtggatta cgtgcctgag acagcatctc ctggattgcc tctgcacagg
     5401 tgtagcatag ccgtgatcct gctgacagat ctgatcattg accacagcgt gaaggtagag
     5461 tggggaagtt acctgcatct tcttcttcat gcagttttta tagggtttga ccactgccac
     5521 cctgaggtgt atgaacattg caaacgcctg ctgctgcatt tactaatagt gatgggaccc
     5581 aacagtaaca tccgaacagt cgcctctgtc ctcctcagga acaaggaatt caatgagccc
     5641 agggtgctga ccgtcaaacc aacagcacac tcagattaca ctttcacagc aggcattaac
     5701 gacttcacac ccgattacca gccgtcccct atgaccgact cagggcttag ctccagttct
     5761 acctcctcta gtatcagctt agggaacaac agcgctgcca tttcccacct ccaagccacc
     5821 ctcctcggcg aggtggacct ctcagtggag caggatggaa aagtcaaaac cctcatggag
     5881 ttcattacct caagaaaacg agggcccctt tggaaccatg aggacgtttc ttctaagaac
     5941 cccagcatca agagtgctga ccaactcacc acgttcctga agcacgtggt ttctgtcttc
     6001 aagcagtcga atgcagaggg aatacacttg gagcgtcatc tcagcgaggt tgccctgcag
     6061 acggcccttt cttgttcttc tcgacactat gctgggagat ccttccagat tttcagggca
     6121 ctgaagcagc ccctgtctgc aaatacactc tccgatgtcc tctccaggct tgtggaaacc
     6181 gtaggggacc caggggagga cgcacaggga tttgtgattg aactgcttct caccttggaa
     6241 tctgcaattg ataccttggc tgaaaccatg aagcactatg acctgctatc tgccctctct
     6301 caaacctcat accacgaccc tgtaatgggg aacaagtatg cagctaacag aaaaagcacg
     6361 ggccagctca atctaagcac gagtcctatc aacagcagca gccatttggg atgcaacggt
     6421 gacacaagaa gtaactcgtt gaggctgagt ctagttggtg accgcagagg tgatcggcgg
     6481 cggagtaaca cactggacat aacagatgga cggacaaacc acggtggtag cttggtgagg
     6541 actcgaagcc tttcctcgct gagagagaaa ggagtgtatg acacgcagcc ccctacggaa
     6601 ccgggcaacc tgatggccac catcttttgg atagcaacgt ctctgttaga atctgactat
     6661 gaatatgaat acctcctggc cctcaggctt ctcagcaaac tgctcaccca cttgcctctg
     6721 gataagtcgg agagtcggga gaagattgaa agcgtacaga gcaaattgaa gtggagtaac
     6781 ttcccaggcc ttcagcagct cttccttaag ggctttacct cagtgtctac ccaagagatg
     6841 accgtgtacc tcctcagtca gctcatttcc gtctccaaac acacactggt ggatccgtcc
     6901 cagttgtcag gatttcctct taacatcctt tgcttactgc ctcacctaat ccagcatttt
     6961 gacaacccga ctcagttttg caaagaaaca gctagtcgga tagcaaaggt ctgtgcggaa
     7021 gagaagtgcc caacgctggt gaacctcgct cacatgatga gcttgtacag tacacacacc
     7081 tactccagag actgtgccaa ctggatcaac gtggtgtgcc ggtacctgca tgactctttc
     7141 tcagaggcga ccttcagtct tgtgacttac ctggcagagc tgttagaaaa ggggctggcc
     7201 agcatgcagc agtccttgct gcagatcatc tacagtctgt tgagccacgt tgacttgtcc
     7261 gcagccccag ccaagcagtt caatctggag atcacgaaga ccattggcaa atatgtccag
     7321 agcccgtact ggaaggaagc cctcaacatc ctgaagctgg tggtgtcccg ctctgcaagt
     7381 cttgttgtcc ccaatgacat ccccaaggcc tacggggtag atgtaggttc tcccgaaatc
     7441 tccttcgcta aaattttcaa caacgtttcg aaggagctgc ctggcaagac cttagatttt
     7501 cacttcgaca tctctgagac acccatcatt gggaacaagt atggaggcca gcacagtgcg
     7561 gcgggaagga acgggaaggc aaaggtgatt gcagtcacca ggagcacgtc ctccacctcc
     7621 tctggctcaa catccaatgc cctggtaccc gtgagctgga aaaggcctca gttatcacag
     7681 cggagaacta gagagaagct gatgagcgtg ctttccctct gtggccccga gtctgggctc
     7741 cccaagaacc cttctgttat attttcttca aatgaggatt tggaagttgg ggaccaacaa
     7801 accagcttga tttccactac cgaggacata attcaggaag aagaagtagc cgtcgaagac
     7861 agcagcagtg aacagcagtt tggcgtcttc aaggacttcg acttcttgga cgtcgagttg
     7921 gaagatgcag agggagagag catggacaat ttcaactggg gagtccgccg gcgctcgctg
     7981 gacagtattg acaaaggaga cacaccatcc ctccaggagt gcccctgttc cagcagcacc
     8041 cccagcctga ccttgacgaa ccaagaggat actgatgagt cctcggagga agaagccgcc
     8101 ctcacggcaa gccagatcct gtcacgcaca cagatgctca acagtgactg tgtaccggac
     8161 gacctgatgc ccgaccacca ggacctgctc cagtctcagg actctgccag cagcaacacc
     8221 acggaagacg tgctgcagat ccgagacgag acccccagtc tggaggcctg tctagataat
     8281 gctagctgcc agctgcctga ggatacaagt tcagtattaa aggaggagca tgttacagcc
     8341 tttgaagatg aagggccata ccttattcaa gaccaacagg acccgctagt ctgtcgggga
     8401 attcttgatt tagaagaaac tgacatgcca gagcctctgg cccctgaaag ctatcccgag
     8461 tccgtctgcg aagaggacgt caccttggct ttaaaagagt tggatgaacg gtgtgaggag
     8521 gaagaggctg atttctctgg gctgtcgagt caagaggaag atgaacaaga cggttttcca
     8581 gaggtgcaga cctcgcctct cccgacgccc tttctgtctg ccataatagc agcttttcag
     8641 ccaatggctt acgaggacga ggaagaagcg tggcgctgtc acgtcaatca gacgctgtcg
     8701 gacacagacg ggtcctgtgc ggtgttcact ttccatgtgt tttcaagact gttccagaca
     8761 attcaaagga agtttggaga gataactaat gaggctgtgg gctttcttgg caagagtctg
     8821 cagcgcattg gtaccaagtt taaaagctca ttggaagtaa tgatgacgtg ttctgaatgc
     8881 cccactgtct tcgtggatgc cgaaacgctg atggcgtgcg gtttgctgga aacactcaag
     8941 tttggcgtct tggagctcca ggaacatctg gatacttaca ccaccaagag agaagcagct
     9001 gagcagtggc tagacaactg caagaggaca tttggtgcca acgaagacat agacaggata
     9061 aacaccaatg cacacgagct ggaactctgc aggaggttgt acaggctaca ctttcagctg
     9121 ctgcttctgt tccaggccta ctgcaaactc atcaaccaag taaacgccat caagaatgaa
     9181 gcagaggtca tcaacatgtc ggaagagctc acccagctgg aaggcatcct taaggaagcc
     9241 gaggccgcct cagaaaatga agaaaccgac atttccaaag ccgcacagac cacaatagaa
     9301 accgccattc attctctgat cgaaactttg aagaacaagg aattcgtatc agctgtggca
     9361 caagtcaaag cgtttagaac cctctggccc agtgacatct tcggcagctg tgacgacgac
     9421 cccgtgcaga cactcctaca catctatttc catcaccaga cgctaggcca gacgggcagt
     9481 ttcgcggtca tcggctccaa cctggacatg tcagaagcta actgcaaact gatggagctt
     9541 aacctggaga tcagagagtc tctccgcatg gtgcagtcac acccactcct agcacaggcc
     9601 aaaccagtcg gaaagacggc gagcgctgga ttctgagcaa cttccgcccc tcaagaggga
     9661 gtgagctgag gatgatgaag acttttagcc gagcaccttt catgaaccct tgtgcttcgc
     9721 tgaaaaccct ggggcagcac ctttccctgt agtctactaa taacttcaaa ctgtccaaaa
     9781 aaaaactgaa gaaaatatct gaccgcttaa ctgctgccta gacctctaca gcaactgtat
     9841 gaagaaggga ttttttatta ttattaacct atgtgaataa gaataagggc taaaagtaat
     9901 gcatacaaac tacattactc tggagaaaga aagaaattcc gaggatgttt gcaataatgg
     9961 cctccaagac attgcagggc aggtgaagtg aggctgggat cggggccaat tcattagctg
    10021 aagacctgtg cctgctgggc cacgtggatt tctagccgtc atcatcataa acgcatagtt
    10081 gacacttagt attcaacttg accacccagt cagacttaat aacacagact tatttgcaaa
    10141 aaccattggg tccggggttg tgttttgggg gtttttgttt gtttgtttgt ttttttccaa
    10201 cttatggcat aagggtttgg ggtgtttggg ttggtttttt tttttttttt ttttttggtc
    10261 tgtataagga agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tcagtcctat tttcaaggtg
    10321 tggatgtctg gtgacagctt ctcagagcat gcctaaaaga gcactgcaag attatttttg
    10381 aaaaaatttt attttattag atctaactct tcatagtgtg taaatgtcag aacactttaa
    10441 taatatttta aagctgggtt ttccccagtg tctcaaaaaa aaaaaagaaa taatatatct
    10501 cttaacgtta ttggactctg ctgctcagct ctctgatcag tgcttttgtt gatattgttg
    10561 ataactaacc aaagcagacg cctgcagaga ctttaaaatg taaaataaag acgcacgctg
    10621 cccgccagcg cctcccatta cacaagttaa cttatttcac tcagtaactt atagacaccg
    10681 catagactaa aacctgtatt ttcttgtaca ttcgtgccac gcactgttct atcagaaaac
    10741 acgtacaaag ctaaaggaaa agttgtggtc accgatggtg gaccgtgtgt tctgcgggct
    10801 ctgaatgatg gctgcagact tcaagagaag aggtgcaaat gacttgtgtg tttatgcagg
    10861 actcagactg gtttcaggct aacggaaccc ttggggctac aggggaaaga caggaagcct
    10921 gaagactgac tcccaaaacg cgcaatacac ttctccaccg tctaagtctg tagcgtaaca
    10981 aactggatcc tgtccctttt tttttttttt ttaatagaat tttgtaaagg aaatgaatgt
    11041 agtcccacga ctcctctgat ttgaaaggaa caccttgtat tttttatatg catctctttt
    11101 ccactgtgac ttttattttc agactgggct ctgtggttcc agagtttaga atgtagaaat
    11161 gaattgctta gctttgcctt ctcccggggg cgtggcccct gacagaaatg tgattatgct
    11221 caagtgcatt aatcgggggc actgtgcatg ccgctcgact gcggatcgtg gtcacgtttc
    11281 ctggaaaatt ctataactgg tcacagcaca ttcataatca ctgtattttt tgacccagat
    11341 aaaaaaaatt attttaatgg tgttctggta ctgtaaatgg tgccctttaa attattaata
    11401 actcttgggc tgggggtggg caggcacagg gatggtgtcc agagacacgc cacacttcac
    11461 atcccttctc ccaatttttc tcaccctcct tacatccttt ttgttaaaaa taaaaaagca
    11521 ttgtagctgt t
//
LOCUS       NM_001427223            5133 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus cordon-bleu WH2 repeat protein-like 1 (Cobll1),
            mRNA.
ACCESSION   NM_001427223
VERSION     NM_001427223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5133)
  AUTHORS   Xiong,X., Liu,J., He,Q., Dai,R., Zhang,H., Cao,Z., Liao,Y., Liu,B.,
            Zhou,Y., Chen,J., Liu,J. and Chen,M.
  TITLE     Long non-coding RNA NORAD aggravates acute myocardial infarction by
            promoting fibrosis and apoptosis via miR-577/COBLL1 axis
  JOURNAL   Environ Toxicol 36 (11), 2256-2265 (2021)
   PUBMED   34355838
  REMARK    GeneRIF: Long non-coding RNA NORAD aggravates acute myocardial
            infarction by promoting fibrosis and apoptosis via miR-577/COBLL1
            axis.
REFERENCE   2  (bases 1 to 5133)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   3  (bases 1 to 5133)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5133)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.11268.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               JAXUCZ010000003.1  70322346-70322586   c
            242-430             JAXUCZ010000003.1  70235757-70235945   c
            431-632             JAXUCZ010000003.1  70223093-70223294   c
            633-861             JAXUCZ010000003.1  70220179-70220407   c
            862-959             JAXUCZ010000003.1  70212322-70212419   c
            960-1184            JAXUCZ010000003.1  70211992-70212216   c
            1185-1347           JAXUCZ010000003.1  70189433-70189595   c
            1348-1422           JAXUCZ010000003.1  70188681-70188755   c
            1423-1527           JAXUCZ010000003.1  70187362-70187466   c
            1528-1756           JAXUCZ010000003.1  70183849-70184077   c
            1757-1854           JAXUCZ010000003.1  70182802-70182899   c
            1855-3752           JAXUCZ010000003.1  70172252-70174149   c
            3753-3932           JAXUCZ010000003.1  70170033-70170212   c
            3933-5133           JAXUCZ010000003.1  70161372-70162572   c
FEATURES             Location/Qualifiers
     source          1..5133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..5133
                     /gene="Cobll1"
                     /note="cordon-bleu WH2 repeat protein-like 1"
                     /db_xref="GeneID:311088"
                     /db_xref="RGD:1308954"
     exon            1..241
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..4019
                     /gene="Cobll1"
                     /note="Cobl-like 1"
                     /codon_start=1
                     /product="cordon-bleu protein-like 1"
                     /protein_id="NP_001414152.1"
                     /db_xref="GeneID:311088"
                     /db_xref="RGD:1308954"
                     /translation="MDRSARDPVPRSAPRTPATQSAGSAGRKTKAKAPLPPAEMKGMD
                     VSSAEDPVESIPVSTEQHDNMIDKDIELSVVLPGDVLKSTTVHGSKPMMDLLVFLCAQ
                     YHLNPSSHTINLLSAEENLIKFKPNTPIGMLEVEKVILKPKSLDKKKPTPIIPEKTVR
                     VVINFKKTQKTIVRVSPHSPLQDLAPIICSKCEFDPLHTVLLKDYQAQEPLDLTKSLN
                     DLGLRELYAMDISRESCQISHNPDIVKEKENKGIFSFFQRSKKKREQTASAPATPLVS
                     KHRPSFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPTSQGAAQGQERRASCVERSTS
                     VDDTDKSSSEGFMVRTGSLQLSGSTSVGTSSLKRTKRKAPAPPSKPSLTETDEGSSAA
                     AHGLPLEDGIVPDSISEVSSPEGMSSPEGPGFLSQEECSVPKPMDEISEGPGTPEAAV
                     ASMTSGVSSDYSLEEIDEKEELMEASKDQAGSVKSPTIASASTDMIITAENDPDSALS
                     ISDGETSPGSKGNTPEGRNPEGQGPHHPVECLIGNENNVSDSIKDLKTLSPNQESVIQ
                     NEVVVCATSTDYVKNRPREMEATIEGEAQKKVGDVEAERLSGSPAGRMDDVQSSRENH
                     LTASPGPDQKSNQPRVEKTKMQDAAIQATPACSTFDGNHEAHNSPDLRVDETAQTLGS
                     STSTQHSSASFQDSVNASREVRSQGTSTYVQDRLPVKEAACTYGNNDALSPIDGSGKN
                     PAASSLKNFPLYRQDNHPKPKPSNEITREYIPKIGMTTYKIVPPKSLEVVKDWDSEAA
                     GKKDNQKTLAVAQKHAIETMTETAVQAEALVTSKNSQQPQPDRTPKPSSGTEHPLHRT
                     VSSPVGTEMNPPKPPRMTTDTGTIPFAPNLEDINNILESKFRSRASNPQAKPSSFFLQ
                     MQKRASGHYVTSAAAKSVHTAPGPTPKEPTIKEVQRDPQLPPEQCLSPLSERTHSAPL
                     PNISKADDNRIQKPAETSPPPVAPKPMALPAETSPPAVAPKPMAFPAETSLPPVSPKP
                     MALPTEASSSPISPKPMAPPAEASIPPVVPKPMAPPAEASPLPVAPKPMAFPAETSLP
                     PVAPKPMALPTEASPPPVAPKPLALPGSQGASLNLKTLKTFGAPRPYNSSAPSPFALA
                     VVKRSQSFSKASPESPSEDSSAQPPAAIQDGKTQTVNQPTVGSQHDGVDKQNKPVQNE
                     HSSQRLTPADGPSSFTLQRQSSLNFQSSDPEHIRQSLLTAIRSGEAAAKLKRVTVPSN
                     RISVNGKSGLSQPMSIDAQDSC"
     misc_feature    378..578
                     /gene="Cobll1"
                     /note="Raf-like Ras-binding domain; Region: RBD;
                     pfam02196"
                     /db_xref="CDD:460485"
     misc_feature    378..578
                     /gene="Cobll1"
                     /note="Raf-like Ras-binding domain; Region: RBD;
                     pfam02196"
                     /db_xref="CDD:460485"
     misc_feature    630..866
                     /gene="Cobll1"
                     /note="Cordon-bleu ubiquitin-like domain; Region: Cobl;
                     pfam09469"
                     /db_xref="CDD:462810"
     misc_feature    630..866
                     /gene="Cobll1"
                     /note="Cordon-bleu ubiquitin-like domain; Region: Cobl;
                     pfam09469"
                     /db_xref="CDD:462810"
     misc_feature    <2763..3590
                     /gene="Cobll1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <2763..3590
                     /gene="Cobll1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    3861..3938
                     /gene="Cobll1"
                     /note="Wiskott-Aldrich Syndrome Homology (WASP) region 2
                     (WH2 motif), and similar proteins; Region: WH2; cl41728"
                     /db_xref="CDD:425359"
     misc_feature    3861..3938
                     /gene="Cobll1"
                     /note="Wiskott-Aldrich Syndrome Homology (WASP) region 2
                     (WH2 motif), and similar proteins; Region: WH2; cl41728"
                     /db_xref="CDD:425359"
     misc_feature    order(3873..3878,3882..3890,3894..3902,3924..3935)
                     /gene="Cobll1"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409196"
     misc_feature    order(3873..3878,3882..3890,3894..3902,3924..3935)
                     /gene="Cobll1"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409196"
     exon            242..430
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..632
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..861
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..959
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1184
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1422
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1527
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1756
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1854
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..3752
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3932
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..5133
                     /gene="Cobll1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccgcagg tggaagcgcc ccggggaggc ggggctgccc ccagctgccg tgggtcgagg
       61 cgggctcttg gctgtcccgc tcccgccctg acccgccggc ctctcccacc ccagcagtga
      121 cgcgccgcct ccgagctcga gcccgcgccg cggccagcag cgcgatggac cgcagtgccc
      181 gggatcccgt accccgcagc gcgcctcgca cccccgccac gcagtctgcc ggctctgcag
      241 ggaggaaaac aaaagcgaag gcacctctcc cccctgctga gatgaagggc atggatgtct
      301 cttcggctga ggatcctgta gaatctattc ctgtctccac agagcaacat gacaatatga
      361 tagataaaga catcgaactc tcggtggtcc tgcctggaga tgttctcaaa tctactacag
      421 ttcatggcag taagcccatg atggacttgc tggtgttcct ctgtgcacag tatcacttaa
      481 acccatcaag tcacacaatc aacttgctgt ctgctgaaga gaatctcatc aaatttaagc
      541 caaacacacc aataggaatg ctggaggtag aaaaggtcat tttaaagccg aaatctctgg
      601 ataagaaaaa acctacacct ataatcccag agaaaactgt gagagtagtg atcaatttta
      661 agaagacaca gaagaccata gtgagagtta gtccccactc accgcttcaa gaccttgctc
      721 ccattatatg cagtaaatgt gagtttgatc cattgcatac agtgttgttg aaggattacc
      781 aggctcagga gcccctcgac ctcacaaagt ctcttaatga cctgggacta agagagttat
      841 atgccatgga tatcagcaga gagtcctgcc aaatatcaca taacccggac attgtgaagg
      901 agaaagaaaa caaagggatt ttcagctttt tccaacgcag taagaaaaag cgagagcaaa
      961 ctgccagcgc tcctgcgacc ccactagtga gcaagcaccg tccttctttt acgaggtcca
     1021 acaccatttc caaaccctac atttccaaca cgctgccctc tgatgcaccc aagaagaggc
     1081 gtgccccgct gccacccatg cccacatccc agggtgctgc tcaaggccag gagaggcgcg
     1141 cttcttgtgt ggagagatcc accagtgtgg acgacacgga taagagttcc tctgaaggat
     1201 tcatggtgag gacaggatca ctgcaactca gtggcagtac atcagtagga acttcatctc
     1261 ttaagagaac gaagcgaaaa gcacctgccc caccttcgaa accctccctg actgagaccg
     1321 atgaagggag ctctgcggct gctcatggcc tacctttgga ggatgggatt gttccagaca
     1381 gcatttcaga agtgagctct cctgagggta tgtccagccc agagggcccg gggttcctaa
     1441 gccaggaaga gtgctctgtg cccaagccaa tggatgaaat ctctgagggc cctggaactc
     1501 cagaggcagc tgtagcttcc atgacctctg gcgtaagctc ggattacagt cttgaagaga
     1561 tagatgaaaa ggaagaactg atggaggcgt ctaaagatca ggctggaagt gtgaagtcgc
     1621 ctaccattgc ttcagcatct acggatatga taattacagc ggagaatgat cctgattcag
     1681 ccctcagcat cagtgatgga gagacctctc caggctctaa gggaaacact ccagaaggca
     1741 gaaacccaga ggggcaaggg ccacatcatc ctgttgagtg ccttataggc aatgagaaca
     1801 atgtatctga cagtataaaa gacttgaaga cactgagccc aaaccaagag agtgtaattc
     1861 aaaatgaagt cgtggtctgt gctacaagca cagattacgt gaaaaacaga ccaagggaaa
     1921 tggaagccac catagaagga gaggcacaga agaaagtcgg ggatgtggaa gctgaaagat
     1981 tgtcaggctc tcctgcaggt agaatggatg atgttcaaag ttcaagggaa aatcatctaa
     2041 cagcatcacc aggaccagat caaaaatcga atcaaccacg tgtagagaag acaaaaatgc
     2101 aggatgcagc aattcaggcc acccctgcct gcagcacttt tgatgggaat cacgaagccc
     2161 ataattcacc tgacctcagg gttgatgaga ctgcacagac tttgggtagc agcacatcaa
     2221 ctcagcactc ctctgcaagc ttccaggatt ctgtaaatgc ctcaagagaa gtcaggagtc
     2281 agggcacctc aacctatgta caagatagac tccctgtgaa agaggcagct tgtacttatg
     2341 ggaacaatga cgctttatct cctatagatg gaagtggtaa gaatccggct gcttcttccc
     2401 taaagaactt tccactttat aggcaagaca accaccccaa gccaaaacct tcaaatgaaa
     2461 ttacgagaga gtacatacct aaaattggaa tgactactta caaaatagtg cctccgaaat
     2521 ccctggaagt ggtgaaagac tgggactcag aagcagcggg gaagaaagat aaccaaaaga
     2581 cgcttgctgt agcacagaag catgcgattg agactatgac agagactgcc gtgcaagcag
     2641 aagcccttgt cacgtctaaa aactcacagc agcctcagcc tgaccgtaca ccaaagccca
     2701 gctcaggaac agagcatcct ttgcacagga ctgtgagctc accagttggt accgagatga
     2761 accctcccaa gcctcccagg atgactacgg acactggcac cattcctttt gcaccgaatt
     2821 tggaagatat taacaatatt ttggagtcaa aattcagatc ccgagcttcg aatccccagg
     2881 ccaaaccaag ttcattcttt ttgcagatgc aaaagagagc ctcaggccac tatgtgacat
     2941 ctgcagctgc taagagcgtc cacactgccc ctgggcctac ccctaaagaa ccaacaatca
     3001 aggaggtgca aagggaccca cagcttcctc cagagcagtg tctttctccc ttgagtgaaa
     3061 ggactcactc tgctcctctg cccaatattt caaaagctga tgataataga attcagaagc
     3121 ctgctgagac ttctcctcct cctgtagctc ccaagcctat ggctcttcct gccgagacct
     3181 ctcctcctgc tgtagctccc aagcctatgg cttttcctgc cgagacctct cttcctcctg
     3241 tatctcccaa gcctatggct cttcctacag aggcatcttc ttctcctata tctcccaagc
     3301 ctatggctcc tcctgctgag gcctcaattc ctcctgtagt tcccaagcct atggctcctc
     3361 ctgccgaggc ctctcctctt cctgtagctc ctaagcctat ggcttttcct gccgagacct
     3421 ctcttcctcc tgtagctccc aagcctatgg ctcttcctac agaggcctct cctcctcctg
     3481 tagctcccaa gcctttggct cttcctggta gtcagggagc ctcactaaac ctgaagacct
     3541 tgaaaacatt cggggccccg agaccataca acagttctgc cccctcaccc tttgcccttg
     3601 ctgtggtgaa aaggtcacag tcgttcagca aggcatctcc agagtcaccc agtgaggact
     3661 cctctgccca gcctccagct gccatacagg atggaaagac acaaacagta aatcagccta
     3721 cagtgggctc ccaacatgat ggtgttgata agcaaaataa acctgttcag aatgagcaca
     3781 gttctcagag gctgactccc gctgatggcc cgtcatcgtt cacccttcag agacagagtt
     3841 ctctcaactt ccagagctct gacccggagc acatccggca gagcttgctc accgcaatcc
     3901 ggtctggaga ggctgctgcc aagttgaaga gagttactgt tccgtcaaat agaatatctg
     3961 tgaatgggaa gtcggggctc agccagccca tgtccattga tgcccaggac agttgctgac
     4021 atcaccctgc tgtgacgcac ttcaccaacc agctttctgc ctacaagaaa tactgacaaa
     4081 tatatattca gatgtacatt aatatataaa tctgttcaag aataaacatt tgtattatgg
     4141 atttaatgcc aaaagaaaaa aatgagaatt tataatttat aatacttttt ggcctttttg
     4201 ttatagctaa atactgctgc tttagaaatg ttaaacaagg tgtcaatgac ttgtttttcc
     4261 aatgatgagt aatcactgct tatgtttttt ttttcttacg gacacagtgt gcaccatgaa
     4321 acaaaggtgt aaattgagat ttatagatat attgtatgac acagaaacag gcaagcacag
     4381 actaacattt actgcctcag cattaggcta taattagaaa aagaaattat agtacggcct
     4441 ttgttgctga aagatgtgga agactagtaa aacaaataaa taatgttcag ttatttttac
     4501 tgaagagtca ctaggagact tattttatgt ctttttgaat tacaagtgag tgtcggatct
     4561 gtaggaaaca actgagtatt tttaaataga acactttaac ctttagacgt caaattgcac
     4621 aagacaactt taagatattt tctgtatata attatgatgt tgttacacag atattacata
     4681 ttttctaatg ccagaggcct taaaatgttc ctatgaaaat gttgatacat tgtgacagct
     4741 atttcacttt tggtataggg aagaataggg ttagtttatg tgcacattca aaacctcgaa
     4801 gttaaacata tgcaaaatcc caattttaat ttaaaaaaaa tgctaaatta gtcacttatg
     4861 tagctcagat gctagtcacc taaataataa tatatatttt cctgaatgcc aaaatggttg
     4921 agagaaacag tacttgctgt gttggcttac agtggtctag aggtttagaa catgttagtg
     4981 tcctgaactt ccttcagaat ttcattcctc ttttattcaa aaaactacac aatcagcctg
     5041 acactgtttg aactcttact aaagctactg gattatctgt catcttgaca catgtgaacc
     5101 tttttccgtt taataaaagc aagttatata ttt
//
LOCUS       NM_001393858            2473 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 6 (Prmt6),
            transcript variant 1, mRNA.
ACCESSION   NM_001393858
VERSION     NM_001393858.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2473)
  AUTHORS   Yan,W.W., Liang,Y.L., Zhang,Q.X., Wang,D., Lei,M.Z., Qu,J.,
            He,X.H., Lei,Q.Y. and Wang,Y.P.
  TITLE     Arginine methylation of SIRT7 couples glucose sensing with
            mitochondria biogenesis
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30420520
REFERENCE   2  (bases 1 to 2473)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   3  (bases 1 to 2473)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   4  (bases 1 to 2473)
  AUTHORS   Casadio,F., Lu,X., Pollock,S.B., LeRoy,G., Garcia,B.A., Muir,T.W.,
            Roeder,R.G. and Allis,C.D.
  TITLE     H3R42me2a is a histone modification with positive transcriptional
            effects
  JOURNAL   Proc Natl Acad Sci U S A 110 (37), 14894-14899 (2013)
   PUBMED   23980157
REFERENCE   5  (bases 1 to 2473)
  AUTHORS   Neault,M., Mallette,F.A., Vogel,G., Michaud-Levesque,J. and
            Richard,S.
  TITLE     Ablation of PRMT6 reveals a role as a negative transcriptional
            regulator of the p53 tumor suppressor
  JOURNAL   Nucleic Acids Res 40 (19), 9513-9521 (2012)
   PUBMED   22904064
REFERENCE   6  (bases 1 to 2473)
  AUTHORS   Guccione,E., Bassi,C., Casadio,F., Martinato,F., Cesaroni,M.,
            Schuchlautz,H., Luscher,B. and Amati,B.
  TITLE     Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are
            mutually exclusive
  JOURNAL   Nature 449 (7164), 933-937 (2007)
   PUBMED   17898714
REFERENCE   7  (bases 1 to 2473)
  AUTHORS   El-Andaloussi,N., Valovka,T., Toueille,M., Steinacher,R., Focke,F.,
            Gehrig,P., Covic,M., Hassa,P.O., Schar,P., Hubscher,U. and
            Hottiger,M.O.
  TITLE     Arginine methylation regulates DNA polymerase beta
  JOURNAL   Mol Cell 22 (1), 51-62 (2006)
   PUBMED   16600869
REFERENCE   8  (bases 1 to 2473)
  AUTHORS   Miranda,T.B., Webb,K.J., Edberg,D.D., Reeves,R. and Clarke,S.
  TITLE     Protein arginine methyltransferase 6 specifically methylates the
            nonhistone chromatin protein HMGA1a
  JOURNAL   Biochem Biophys Res Commun 336 (3), 831-835 (2005)
   PUBMED   16157300
REFERENCE   9  (bases 1 to 2473)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   10 (bases 1 to 2473)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360194.1647668.1,
                                        SRR26360181.3223959.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2473              JAXUCZ010000002.1  200618318-200620790 c
FEATURES             Location/Qualifiers
     source          1..2473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..2473
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="protein arginine methyltransferase 6"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
     exon            1..2473
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1147
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /EC_number="2.1.1.125"
                     /note="HMT1 hnRNP methyltransferase-like 6"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 6"
                     /protein_id="NP_001380787.1"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
                     /translation="MSLSKKRKLESGVGGAGGEGAEEENGGEQEAAPPRPRRTKRERD
                     QLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQ
                     AGARRVYAVEASAIWQQAQEVVRLNGLEDRVHILPGPVETVELPEQVDAIVSEWMGYG
                     LLHESMLSSVLHARTKWLKEGGLLLPDSAELFVAPISDQMLEWRLGFWSQVKQHYGVD
                     MSCMESFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFR
                     CSCYGSAPLHGFAIWFQVTFPGGDSEKPLVLSTSPFHPATHWKQALLYLNEPVPVEQD
                     TDISGEITLLPSRDNPRRLRVLLRYKVGDHEEKTKDFAMED"
     misc_feature    170..>703
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    170..>703
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
ORIGIN      
        1 gtcggctgcc gggaccaaga tgtcgctgag caagaaaaga aagcttgagt cgggggtcgg
       61 cggcgcagga ggggagggag ctgaggagga aaatggcggg gagcaggagg cagccccgcc
      121 acgaccccgg aggaccaagc gcgagcggga ccagctgtac tacgagtgct actccgacgt
      181 atcggtccac gaggagatga tcgccgaccg cgtccgcacc gacgcctacc gcctaggcat
      241 cctgaggaac tgggccgctc tgcgaggcaa gaccgtgctg gacgtgggcg caggcaccgg
      301 cattcttagc atcttctgcg cccaggccgg ggcccggcgc gtatacgctg tggaggccag
      361 cgccatctgg caacaggccc aggaggtggt gcggctcaac gggttggagg accgcgtgca
      421 catcctgcca ggcccggtgg agacggtgga gctgccggag caagtggacg ccatcgtaag
      481 cgagtggatg ggctacggac tactgcacga gtccatgctg agctccgtgc tccacgcgcg
      541 gaccaaatgg ctgaaggagg gcggtctcct cctgccagat tccgctgagc tcttcgtggc
      601 cccgattagc gaccagatgc tggaatggcg cttgggtttc tggagccaag tgaagcagca
      661 ctatggcgtg gatatgagct gcatggaaag cttcgccacg cgctgcctca tgggccattc
      721 ggagatcgtg gtgcagggtc tgtccggaga ggacgtgctg gcccggccac agcgctttgc
      781 ccagctcgag ctggcccgcg ctggcctgga gcaggagctg gaggccggtg tgggcgggcg
      841 cttccgctgc agctgctatg gctccgcgcc tctacatggt tttgccatct ggtttcaggt
      901 aacctttcct ggaggggact cggagaaacc tctggtgctg tccacctcac ctttccaccc
      961 ggccacgcac tggaagcagg cgctcctcta cttgaatgag ccggtgccgg tggaacaaga
     1021 tacagacatt tctggagaga tcaccctgct gccctcccgg gacaaccccc ggcgtctgcg
     1081 cgtacttctg cgctacaaag tgggggacca tgaggaaaag accaaagact ttgccatgga
     1141 ggactgagcg ttgccttttc tcccatctac cttcttagga aggtcagaag agaaagggaa
     1201 atcaatctcc tatgcaagta ggggacgtat ctgtctcttt tacctcacca cttctgagaa
     1261 agggagtgac cagacttcat ttgaggacat tcttctggca atgtttattt taaaagtgag
     1321 cattcctgac caaggactga tgcaatgtgc ttattaatgg gcttttaaac ctggaaagca
     1381 tgtagtgtga aactcttgta ttactgtttc ttttgtttaa ctgcaggggt gggggcagta
     1441 aacgcgagat tataattggt ccacgcgcta atctgacaac tcatccctta tcaatatgaa
     1501 actgggagaa aggcaaaatg ttttgattac atttcagaaa cttgcagcat tattttttag
     1561 agctgtattt ttttttagtc taaattctct caagtctccg gtgcctgtag gatatggtac
     1621 ctgtatttcc ttatattcta aataaaattc ctcctgttag taaggaagtg gagcacaggt
     1681 gaagtactta taaataaccc cattctcttt actcttaatt tacggcatgc taaatttgat
     1741 gaacacttaa ccttagtaaa gtggcttaat tttacagcct gtctaggcaa ttctaaaagt
     1801 gacaggagaa aaaaataatc taaaagtgaa ataatatggg gtttaaatat ttttatttta
     1861 aagactgagc caagaaaatc tatgttttat aatatttttg tcattcttgt aaagcagtgt
     1921 aatagggaag attgcttgaa cctatcgcat gggtgaaccc tttacctctg tgcttgcttt
     1981 atttaagcac aggtatagaa aggtacacga gcaccctgcg tacatctagt aaagttcctg
     2041 tcttcgattc tttttagttc agccaaatgt gaacatggtg aatatgggga agttagtttt
     2101 aatgaagtac gagtcacatt gtcagattta tttcactgac ggagctttcc tcctttctgt
     2161 ggcaaataaa atggcattct cactttttat agttgaggtc tttagacttt gtgtcccctc
     2221 tgtgagttta tgataatgct gttacctttc tcatggtctc agttcctaag tgttacagct
     2281 cctgcagaac acagcttgag gacagctcaa attatgatta acagggtttt gaattctagc
     2341 tttgtaagac ttaatgggtg tgaaaaactg ctgttcttaa ctgcccttga atttcacttt
     2401 ttgtaacctt ggttctgttt tggcttttta aagatattca ttgtatatta aattgctaaa
     2461 gtattaaaac taa
//
LOCUS       NM_024363               1201 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 1 (Prmt1),
            mRNA.
ACCESSION   NM_024363
VERSION     NM_024363.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Shen,Q., Xiao,Y., Cheng,B., Sun,Z., Hu,Y., Yang,H. and Luo,Y.
  TITLE     PRMT1 promotes extracellular matrix degradation and apoptosis of
            chondrocytes in temporomandibular joint osteoarthritis via the
            AKT/FOXO1 signaling pathway
  JOURNAL   Int J Biochem Cell Biol 141, 106112 (2021)
   PUBMED   34715362
  REMARK    GeneRIF: PRMT1 promotes extracellular matrix degradation and
            apoptosis of chondrocytes in temporomandibular joint osteoarthritis
            via the AKT/FOXO1 signaling pathway.
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Price,O.M., Thakur,A., Ortolano,A., Towne,A., Velez,C., Acevedo,O.
            and Hevel,J.M.
  TITLE     Naturally occurring cancer-associated mutations disrupt
            oligomerization and activity of protein arginine methyltransferase
            1 (PRMT1)
  JOURNAL   J Biol Chem 297 (5), 101336 (2021)
   PUBMED   34688662
  REMARK    GeneRIF: Naturally occurring cancer-associated mutations disrupt
            oligomerization and activity of protein arginine methyltransferase
            1 (PRMT1).
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Ma,J., Wu,Y. and He,Y.
  TITLE     Silencing circRNA LRP6 down-regulates PRMT1 to improve the
            streptozocin-induced pancreatic beta-cell injury and insulin
            secretion by sponging miR-9-5p
  JOURNAL   J Bioenerg Biomembr 53 (3), 333-342 (2021)
   PUBMED   33826088
  REMARK    GeneRIF: Silencing circRNA LRP6 down-regulates PRMT1 to improve the
            streptozocin-induced pancreatic beta-cell injury and insulin
            secretion by sponging miR-9-5p.
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Zhu,Y., Yu,C. and Zhuang,S.
  TITLE     Protein arginine methyltransferase 1 mediates renal fibroblast
            activation and fibrogenesis through activation of Smad3 signaling
  JOURNAL   Am J Physiol Renal Physiol 318 (2), F375-F387 (2020)
   PUBMED   31813251
  REMARK    GeneRIF: PRMT1 may mediate renal fibroblast activation and renal
            fibrosis development through activation of the TGF-beta/Smad3
            signaling pathway.
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Jeong,M.H., Jeong,H.J., Ahn,B.Y., Pyun,J.H., Kwon,I., Cho,H. and
            Kang,J.S.
  TITLE     PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in
            cardiomyocytes
  JOURNAL   Cell Death Dis 10 (12), 903 (2019)
   PUBMED   31787756
  REMARK    GeneRIF: PRMT1 suppresses ATF4-mediated endoplasmic reticulum
            response in cardiomyocytes.
            Erratum:[Cell Death Dis. 2020 Mar 23;11(3):203. doi:
            10.1038/s41419-020-2373-8. PMID: 32251281]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1201)
  AUTHORS   Pawlak,M.R., Scherer,C.A., Chen,J., Roshon,M.J. and Ruley,H.E.
  TITLE     Arginine N-methyltransferase 1 is required for early
            postimplantation mouse development, but cells deficient in the
            enzyme are viable
  JOURNAL   Mol Cell Biol 20 (13), 4859-4869 (2000)
   PUBMED   10848611
REFERENCE   7  (bases 1 to 1201)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 1201)
  AUTHORS   Tang,J., Gary,J.D., Clarke,S. and Herschman,H.R.
  TITLE     PRMT 3, a type I protein arginine N-methyltransferase that differs
            from PRMT1 in its oligomerization, subcellular localization,
            substrate specificity, and regulation
  JOURNAL   J Biol Chem 273 (27), 16935-16945 (1998)
   PUBMED   9642256
REFERENCE   9  (bases 1 to 1201)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   10 (bases 1 to 1201)
  AUTHORS   Gary,J.D., Lin,W.J., Yang,M.C., Herschman,H.R. and Clarke,S.
  TITLE     The predominant protein-arginine methyltransferase from
            Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 271 (21), 12585-12594 (1996)
   PUBMED   8647869
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U60882.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U60882.1, FQ219843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1201
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="protein arginine methyltransferase 1"
                     /db_xref="GeneID:60421"
                     /db_xref="RGD:62020"
     exon            1..38
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1064
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /EC_number="2.1.1.319"
                     /function="methylates (mono and asymmetric dimethylation)
                     the guanidino nitrogens of arginyl residues present in a
                     glycine and arginine-rich domain; (e.g. can methylate
                     recombinant hnRNPA1 as well as crude histones)"
                     /note="histone-arginine N-methyltransferase PRMT1;
                     heterogeneous nuclear ribonucleoproteins
                     methyltransferase-like 2"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 1"
                     /protein_id="NP_077339.1"
                     /db_xref="GeneID:60421"
                     /db_xref="RGD:62020"
                     /translation="MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGI
                     HEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
                     SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVL
                     HARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPL
                     VDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTR
                     CHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTID
                     LDFKGQLCELSCSTDYRMR"
     misc_feature    135..>656
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    135..>656
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="Predicted RNA methylase [General function
                     prediction only]; Region: COG4076"
                     /db_xref="CDD:443253"
     misc_feature    630..632
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIF0; propagated from
                     UniProtKB/Swiss-Prot (Q63009.1); acetylation site"
     misc_feature    645..647
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIF0; propagated from
                     UniProtKB/Swiss-Prot (Q63009.1); acetylation site"
     misc_feature    858..860
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99873; propagated from
                     UniProtKB/Swiss-Prot (Q63009.1); phosphorylation site"
     misc_feature    867..869
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99873; propagated from
                     UniProtKB/Swiss-Prot (Q63009.1); phosphorylation site"
     exon            39..140
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            141..296
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..360
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..503
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..591
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..707
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..858
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..980
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1201
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1201
                     /gene="Prmt1"
                     /gene_synonym="Hrmt1l2"
                     /note="109 A nucleotides"
ORIGIN      
        1 agatggcggc agccgaggcc gcgaactgca tcatggaggt ttcctgtggc caagcagaaa
       61 gtagtgagaa gcccaatgct gaggacatga catccaaaga ctactacttt gactcctatg
      121 cccactttgg catccacgag gagatgctaa aggatgaggt gcgaaccctc acgtaccgca
      181 actccatgtt tcacaatcgg catctcttca aagacaaggt ggtgctggat gtgggctcgg
      241 gcactggcat cctctgcatg ttcgctgcca aggcaggggc ccgcaaggtc attgggatcg
      301 agtgctccag tatctctgat tatgctgtga agattgtcaa agccaataag ttagaccacg
      361 tggtgaccat catcaagggc aaggtggagg aggtggagct gcctgtggag aaggtggaca
      421 tcatcatcag cgagtggatg ggttattgcc tcttctatga gtccatgctc aacactgtgc
      481 tgcacgctcg tgacaagtgg ctggcacctg atggcctcat cttcccagac cgagccaccc
      541 tgtatgtgac agccattgag gaccgacagt ataaagacta caagatccac tggtgggaga
      601 atgtatatgg ctttgatatg tcctgcatta aagacgtggc catcaaggag cccctggtgg
      661 acgtggtgga cccaaagcag ctggtcacca acgcctgcct cataaaggag gtggacatct
      721 acacagtcaa ggtggaggac ctgaccttca cctccccgtt ttgtctgcaa gtgaagagga
      781 atgactatgt gcatgcacta gtggcctact tcaacatcga gttcacccga tgccacaaga
      841 ggaccggctt ctctaccagt cctgagtctc catacacaca ttggaagcag actgtgttct
      901 acatggagga ctacctaaca gtgaagaccg gcgaggagat ttttggcact attggaatga
      961 ggcccaacgc caaaaacaat cgtgacttgg actttaccat cgacctggac ttcaagggtc
     1021 agctgtgtga gctctcttgt tccaccgact accggatgcg ctgaggaggt gccaggctgg
     1081 ccctcctgca aaagggggct caggggctgg gcttggggga tgggagggta catcgtggca
     1141 gtgtttttca taacttatgt ttttatatgg ttgcgtttat gccaataaat cctcagctga
     1201 c
//
LOCUS       NM_053819                740 bp    mRNA    linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus TIMP metallopeptidase inhibitor 1 (Timp1), mRNA.
ACCESSION   NM_053819
VERSION     NM_053819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Xi,X., Yang,Y., Chen,Q., Ma,J., Wang,X., Deng,Y., Wang,X. and Li,Y.
  TITLE     GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic
            retinopathy progression
  JOURNAL   Mol Biol Rep 51 (1), 428 (2024)
   PUBMED   38499842
  REMARK    GeneRIF: GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes
            diabetic retinopathy progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 740)
  AUTHORS   Ahmadighadykolaei,H., Lambert,J.A. and Raeeszadeh-Sarmazdeh,M.
  TITLE     TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From
            MMP-Mediated Degradation
  JOURNAL   Pharm Res 40 (9), 2121-2131 (2023)
   PUBMED   37700105
  REMARK    GeneRIF: TIMP-1 Protects Tight Junctions of Brain Endothelial Cells
            From MMP-Mediated Degradation.
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Huang,S., Chen,M., Yu,H., Lin,K., Guo,Y. and Zhu,P.
  TITLE     Co-expression of tissue kallikrein 1 and tissue inhibitor of matrix
            metalloproteinase 1 improves myocardial ischemia-reperfusion injury
            by promoting angiogenesis and inhibiting oxidative stress
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33355364
  REMARK    GeneRIF: Coexpression of tissue kallikrein 1 and tissue inhibitor
            of matrix metalloproteinase 1 improves myocardial
            ischemiareperfusion injury by promoting angiogenesis and inhibiting
            oxidative stress.
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Yuan,Y., Naito,H., Kitamori,K., Hashimoto,S., Asano,T. and
            Nakajima,T.
  TITLE     The antihypertensive agent hydralazine reduced extracellular matrix
            synthesis and liver fibrosis in nonalcoholic steatohepatitis
            exacerbated by hypertension
  JOURNAL   PLoS One 15 (12), e0243846 (2020)
   PUBMED   33315911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Samper Agrelo,I., Schira-Heinen,J., Beyer,F., Groh,J.,
            Butermann,C., Estrada,V., Poschmann,G., Bribian,A., Jadasz,J.J.,
            Lopez-Mascaraque,L., Kremer,D., Martini,R., Muller,H.W.,
            Hartung,H.P., Adjaye,J., Stuhler,K. and Kury,P.
  TITLE     Secretome Analysis of Mesenchymal Stem Cell Factors Fostering
            Oligodendroglial Differentiation of Neural Stem Cells In Vivo
  JOURNAL   Int J Mol Sci 21 (12), 4350 (2020)
   PUBMED   32570968
  REMARK    GeneRIF: Secretome Analysis of Mesenchymal Stem Cell Factors
            Fostering Oligodendroglial Differentiation of Neural Stem Cells In
            Vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Boujrad,N., Ogwuegbu,S.O., Garnier,M., Lee,C.H., Martin,B.M. and
            Papadopoulos,V.
  TITLE     Identification of a stimulator of steroid hormone synthesis
            isolated from testis
  JOURNAL   Science 268 (5217), 1609-1612 (1995)
   PUBMED   7777858
  REMARK    Erratum:[Science 1995 Oct 20;270(5235):365]
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Chun,S.Y., Popliker,M., Reich,R. and Tsafriri,A.
  TITLE     Localization of preovulatory expression of plasminogen activator
            inhibitor type-1 and tissue inhibitor of metalloproteinase type-1
            mRNAs in the rat ovary
  JOURNAL   Biol Reprod 47 (2), 245-253 (1992)
   PUBMED   1327205
REFERENCE   8  (bases 1 to 740)
  AUTHORS   Roswit,W.T., McCourt,D.W., Partridge,N.C. and Jeffrey,J.J.
  TITLE     Purification and sequence analysis of two rat tissue inhibitors of
            metalloproteinases
  JOURNAL   Arch Biochem Biophys 292 (2), 402-410 (1992)
   PUBMED   1309971
REFERENCE   9  (bases 1 to 740)
  AUTHORS   Docherty,A.J., Lyons,A., Smith,B.J., Wright,E.M., Stephens,P.E.,
            Harris,T.J., Murphy,G. and Reynolds,J.J.
  TITLE     Sequence of human tissue inhibitor of metalloproteinases and its
            identity to erythroid-potentiating activity
  JOURNAL   Nature 318 (6041), 66-69 (1985)
   PUBMED   3903517
REFERENCE   10 (bases 1 to 740)
  AUTHORS   Gasson,J.C., Golde,D.W., Kaufman,S.E., Westbrook,C.A., Hewick,R.M.,
            Kaufman,R.J., Wong,G.G., Temple,P.A., Leary,A.C., Brown,E.L. et al.
  TITLE     Molecular characterization and expression of the gene encoding
            human erythroid-potentiating activity
  JOURNAL   Nature 315 (6022), 768-771 (1985)
   PUBMED   3839290
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L31883.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31883.1, FQ219856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093045, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..740
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="TIMP metallopeptidase inhibitor 1"
                     /db_xref="GeneID:116510"
                     /db_xref="RGD:621675"
     exon            1..24
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    9..11
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="upstream in-frame stop codon"
     exon            25..156
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..689
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /function="tissue inhibitor of metalloproteinase (type 1)"
                     /note="metalloproteinase inhibitor 1; tissue inhibitor of
                     metalloproteinases 1; tissue inhibitor of
                     metalloproteinase 1; tissue inhibitor of metallopeptidase
                     1"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 1 precursor"
                     /protein_id="NP_446271.1"
                     /db_xref="GeneID:116510"
                     /db_xref="RGD:621675"
                     /translation="MAPFASLASGILLLLSLIASSKACSCAPTHPQTAFCNSDLVIRA
                     KFMGSPEIIETTLYQRYEIKMTKMLKGFDAVGNATGFRFAYTPAMESLCGYVHKSQNR
                     SEEFLIAGRLRNGNLHITACSFLVPWHNLSPAQQKAFVKTYSAGCGVCTVFPCSAIPC
                     KLESDSHCLWTDQILMGSEKGYQSDHFACLPRNPDLCTWQYLGVSMTRSLPLAKAEA"
     sig_peptide     36..104
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     105..686
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /product="metalloproteinase inhibitor 1"
                     /function="tissue inhibitor of metalloproteinase (type 1)"
     misc_feature    105..632
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="Tissue inhibitor of metalloproteinase family;
                     Region: NTR; smart00206"
                     /db_xref="CDD:128502"
     misc_feature    105..632
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="Tissue inhibitor of metalloproteinase family;
                     Region: NTR; smart00206"
                     /db_xref="CDD:128502"
     misc_feature    105..116
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P30120.2);
                     Region: Involved in metalloproteinase-binding.
                     /evidence=ECO:0000250|UniProtKB:P16035"
     misc_feature    144..146
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="Involved in metalloproteinase-binding.
                     /evidence=ECO:0000250|UniProtKB:P16035; propagated from
                     UniProtKB/Swiss-Prot (P30120.2); other site"
     misc_feature    264..266
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30120.2); glycosylation site"
     misc_feature    303..308
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P30120.2);
                     Region: Involved in metalloproteinase-binding.
                     /evidence=ECO:0000250|UniProtKB:P16035"
     misc_feature    336..338
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30120.2); glycosylation site"
     misc_feature    567..569
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01033; propagated from
                     UniProtKB/Swiss-Prot (P30120.2); phosphorylation site"
     exon            157..236
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..363
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..488
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..740
                     /gene="Timp1"
                     /gene_synonym="Timp; TIMP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggactccta gagacacgct agagcagata ccacgatggc gccctttgca tctctggcct
       61 ctggcatcct cttgttgcta tcattgatag cttccagtaa agcctgtagc tgtgccccaa
      121 cccacccaca gacagctttc tgcaactcgg acctggttat aagggctaaa ttcatgggtt
      181 ccccagaaat catcgagacc accttatacc agcgttatga gatcaagatg actaagatgc
      241 tcaaaggatt cgacgctgtg ggaaatgcca caggtttccg gttcgcctac accccagcca
      301 tggagagcct ctgtggatat gtccacaagt cccagaaccg cagcgaggag tttctcatcg
      361 cgggccgttt aaggaacgga aatttgcaca tcactgcctg cagcttcctg gttccctggc
      421 ataatctgag ccctgctcag caaaaggcct tcgtaaagac ctatagtgct ggctgtgggg
      481 tgtgcacagt gtttccctgt tcagccatcc cttgcaaact ggagagtgac agtcattgct
      541 tgtggacaga tcagatcctc atgggctctg agaagggcta ccagagcgat cactttgcct
      601 gcctgccacg gaatccagat ttgtgcacct ggcaatacct tggggtctcg atgacccgaa
      661 gccttcccct ggcaaaagct gaagcctgaa cactgtttac ctttcctcca tctttctttc
      721 tcttaaatgg tgaaataaag
//
LOCUS       NR_172023               3093 bp    RNA     linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus protein arginine methyltransferase 6 (Prmt6),
            transcript variant 3, non-coding RNA.
ACCESSION   NR_172023 NM_001106466
VERSION     NR_172023.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Yan,W.W., Liang,Y.L., Zhang,Q.X., Wang,D., Lei,M.Z., Qu,J.,
            He,X.H., Lei,Q.Y. and Wang,Y.P.
  TITLE     Arginine methylation of SIRT7 couples glucose sensing with
            mitochondria biogenesis
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30420520
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Damez-Werno,D.M., Sun,H., Scobie,K.N., Shao,N., Rabkin,J., Dias,C.,
            Calipari,E.S., Maze,I., Pena,C.J., Walker,D.M., Cahill,M.E.,
            Chandra,R., Gancarz,A., Mouzon,E., Landry,J.A., Cates,H.,
            Lobo,M.K., Dietz,D., Allis,C.D., Guccione,E., Turecki,G.,
            Defilippi,P., Neve,R.L., Hurd,Y.L., Shen,L. and Nestler,E.J.
  TITLE     Histone arginine methylation in cocaine action in the nucleus
            accumbens
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9623-9628 (2016)
   PUBMED   27506785
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Casadio,F., Lu,X., Pollock,S.B., LeRoy,G., Garcia,B.A., Muir,T.W.,
            Roeder,R.G. and Allis,C.D.
  TITLE     H3R42me2a is a histone modification with positive transcriptional
            effects
  JOURNAL   Proc Natl Acad Sci U S A 110 (37), 14894-14899 (2013)
   PUBMED   23980157
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Neault,M., Mallette,F.A., Vogel,G., Michaud-Levesque,J. and
            Richard,S.
  TITLE     Ablation of PRMT6 reveals a role as a negative transcriptional
            regulator of the p53 tumor suppressor
  JOURNAL   Nucleic Acids Res 40 (19), 9513-9521 (2012)
   PUBMED   22904064
REFERENCE   6  (bases 1 to 3093)
  AUTHORS   Guccione,E., Bassi,C., Casadio,F., Martinato,F., Cesaroni,M.,
            Schuchlautz,H., Luscher,B. and Amati,B.
  TITLE     Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are
            mutually exclusive
  JOURNAL   Nature 449 (7164), 933-937 (2007)
   PUBMED   17898714
REFERENCE   7  (bases 1 to 3093)
  AUTHORS   El-Andaloussi,N., Valovka,T., Toueille,M., Steinacher,R., Focke,F.,
            Gehrig,P., Covic,M., Hassa,P.O., Schar,P., Hubscher,U. and
            Hottiger,M.O.
  TITLE     Arginine methylation regulates DNA polymerase beta
  JOURNAL   Mol Cell 22 (1), 51-62 (2006)
   PUBMED   16600869
REFERENCE   8  (bases 1 to 3093)
  AUTHORS   Miranda,T.B., Webb,K.J., Edberg,D.D., Reeves,R. and Clarke,S.
  TITLE     Protein arginine methyltransferase 6 specifically methylates the
            nonhistone chromatin protein HMGA1a
  JOURNAL   Biochem Biophys Res Commun 336 (3), 831-835 (2005)
   PUBMED   16157300
REFERENCE   9  (bases 1 to 3093)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   10 (bases 1 to 3093)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 19, 2021 this sequence version replaced NM_001106466.1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.10595.1,
                                           SRR26643284.3587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1315              JAXUCZ010000002.1  200619476-200620790 c
            1316-3093           JAXUCZ010000002.1  200615780-200617557 c
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..3093
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="protein arginine methyltransferase 6"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
     misc_RNA        1..3093
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /product="protein arginine methyltransferase 6, transcript
                     variant 3"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
     exon            1..1315
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..1147
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001393859.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            1316..3093
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctgcc gggaccaaga tgtcgctgag caagaaaaga aagcttgagt cgggggtcgg
       61 cggcgcagga ggggagggag ctgaggagga aaatggcggg gagcaggagg cagccccgcc
      121 acgaccccgg aggaccaagc gcgagcggga ccagctgtac tacgagtgct actccgacgt
      181 atcggtccac gaggagatga tcgccgaccg cgtccgcacc gacgcctacc gcctaggcat
      241 cctgaggaac tgggccgctc tgcgaggcaa gaccgtgctg gacgtgggcg caggcaccgg
      301 cattcttagc atcttctgcg cccaggccgg ggcccggcgc gtatacgctg tggaggccag
      361 cgccatctgg caacaggccc aggaggtggt gcggctcaac gggttggagg accgcgtgca
      421 catcctgcca ggcccggtgg agacggtgga gctgccggag caagtggacg ccatcgtaag
      481 cgagtggatg ggctacggac tactgcacga gtccatgctg agctccgtgc tccacgcgcg
      541 gaccaaatgg ctgaaggagg gcggtctcct cctgccagat tccgctgagc tcttcgtggc
      601 cccgattagc gaccagatgc tggaatggcg cttgggtttc tggagccaag tgaagcagca
      661 ctatggcgtg gatatgagct gcatggaaag cttcgccacg cgctgcctca tgggccattc
      721 ggagatcgtg gtgcagggtc tgtccggaga ggacgtgctg gcccggccac agcgctttgc
      781 ccagctcgag ctggcccgcg ctggcctgga gcaggagctg gaggccggtg tgggcgggcg
      841 cttccgctgc agctgctatg gctccgcgcc tctacatggt tttgccatct ggtttcaggt
      901 aacctttcct ggaggggact cggagaaacc tctggtgctg tccacctcac ctttccaccc
      961 ggccacgcac tggaagcagg cgctcctcta cttgaatgag ccggtgccgg tggaacaaga
     1021 tacagacatt tctggagaga tcaccctgct gccctcccgg gacaaccccc ggcgtctgcg
     1081 cgtacttctg cgctacaaag tgggggacca tgaggaaaag accaaagact ttgccatgga
     1141 ggactgagcg ttgccttttc tcccatctac cttcttagga aggtcagaag agaaagggaa
     1201 atcaatctcc tatgcaagta ggggacgtat ctgtctcttt tacctcacca cttctgagaa
     1261 agggagtgac cagacttcat ttgaggacat tcttctggca atgtttattt taaaagcact
     1321 gacagcatcg ccttggctat acatgaagag caacgtatgc cacggggtac cagatgatcc
     1381 aaagaagcac cacagtcttt gggatgaaga cacctgggaa agaggaaagc ctgaggtgtg
     1441 tggacaccca ggcactatct gatgtgttat gtggattggg actggtaact gaaaccctta
     1501 gggccacagg cctggattat tagactctag agagagcatc atggtaaagt cccacctacc
     1561 tccctcacac cttaccttta tttagccctc ccaaatttcc caattttgtc gctaatttat
     1621 taaaccaatg agcataatac attctaaagg tcactgtggt aggtatttgg gattacatgc
     1681 tacttgaact ctgcccataa gtagatgtct acactaaagg aagtaaaggc cataatttta
     1741 ggttagttag gacctgggtg gttttagtgt cagaaaagat ggattatttg ttttacacac
     1801 taagtgaaaa aggtttcgta gatgctgaca gaaagttaca tacataattc ttcctggttt
     1861 ggaaatgtga tcatacattg tgcaaggcta aattggaacc caggatatag ctgaggatga
     1921 ctttgaactc tttcctccac cttccacatt ctggagttaa tagctctgta ccactgtgcc
     1981 cagcatagac ccagtttttg gctgaccctt acccacaatt cttgactttt caaaggtaaa
     2041 caaaaattta ctctcatatt aatcccacat gcttcactta aaaacaggag actatgtgcc
     2101 accttaatag taacaagggc tttattattt gatgatgacg ggaaagtgtt tagtactaga
     2161 aaggctctta gacctgccca aaagaaacat ctgcagtgtg taacttgagt ttgacatagt
     2221 gggcactcat ttcaacagcc cttatgttta tttctgtaac aatagtcaaa tgggacactt
     2281 tctagggtct ccagaaaact gaatgcatga cagtagcaaa gacaagtgaa ctccctgtca
     2341 tttgggcagg gatgtaaaag agacaagaaa atggagttca agaaagtgaa tgtgaaaagc
     2401 acctgctgcg aacagctgcc tgccgtcttc tttactgcca gctttgctct tatccccaca
     2461 gtttacctag tgctgaggaa agatggctcc taaggagcat ttactaacag gccccactcc
     2521 tccacatgtt catctctgta tatgtctctc cattaatttc attatcaaca gctacataat
     2581 agctaagcac tgtaataact gagcacatct gcccttcaga gaacagggta cagtgggagc
     2641 agtaaagcag catcagttgt tctcatgcat tcgtaagcct ggaaatcctt cccagctctt
     2701 agctctgctg agtgagtatg gaaagggtgc tgtcaccctt taaggctctc tgaggatcaa
     2761 aggtctgatt cctatcagca ggaagattgt gaacacctga gaaactccca tctgatgttc
     2821 tagaattaga cagtattccc caaaatacta gtctgttcca taatagacca actatattaa
     2881 ataggtaatc cccagctact aaaacaaaga ctctaagcca agtttatggg tcgtctgtgt
     2941 gtctgtgtgt atactgtgtg tatactgtgt gcgcgagtgt gtgcatgtgc acatttgctt
     3001 gtatcttccc caactttctg tgtgattttt atgcttcaat ttgtttatga tttatcctct
     3061 cacttttaat aaatattaca tgtatttttt gaa
//
LOCUS       NR_199197                939 bp    RNA     linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus small lysine-rich protein 1, pseudogene 1
            (Smkr1-ps1), transcript variant 2, non-coding RNA.
ACCESSION   NR_199197
VERSION     NR_199197.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1223309.1,
                                           SRR26360181.228845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000004.1  59569174-59569326
            154-939             JAXUCZ010000004.1  59575882-59576667
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..939
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /note="small lysine-rich protein 1, pseudogene 1"
                     /pseudo
                     /db_xref="GeneID:103692109"
                     /db_xref="RGD:9298384"
     misc_RNA        1..939
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /product="small lysine-rich protein 1, pseudogene 1,
                     transcript variant 2"
                     /pseudo
                     /db_xref="GeneID:103692109"
                     /db_xref="RGD:9298384"
     exon            1..153
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /inference="alignment:Splign:2.1.0"
                     /pseudo
     exon            154..939
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /inference="alignment:Splign:2.1.0"
                     /pseudo
ORIGIN      
        1 agagcgctcg acagcgggct gtctgagtgc ctcggggccg agccccggga gtggggtgag
       61 gcaaaccttg tctaccagca tctgcgcctc cgcacaccgc gaaggcgctc aattggaggt
      121 gcggccacgg ccggggcagg cggcaatacg cgggtaaaag gaagaaaaga aaaggccggg
      181 gcaaggccgg gaagaagcag aagcagaaga agccggaagt agacatcctc agcccggcag
      241 ccatgttgaa cctatactac atcgctcaca atgttgccga ctgcctgtat ctgcgtggct
      301 tcccttggcc aggcgctccc aaagggaaaa gggggaaaaa ataagattta ggtggtagaa
      361 ttcaaagcat gccttggtct caaagaacag aaagtaggag aatgcattta gggtacctca
      421 aggactgcgg gcaagcgggc tctaacagcc aagtagaaac atgtagccac tgtacttttc
      481 tgtggtaaat aatgacaaac atttttattt ccacagctga gccaggcaat aggtaagcca
      541 ctttgttttt tcagaagtaa ccaggaaaac caaacccaag tagttcataa aggctaccct
      601 ggcattggta gtgttttttt taaatattat actcataaat ctagactgaa ttaaaccttg
      661 ttctcagaag gcagctccag gttgcatgag tcgttttctt ttgtgagagc tggctcagag
      721 aagcagagag ctcaggccta acttgtaagc acgttttctg ctgtggtttg gtttggggtc
      781 tctctctctc tctctctctc tctctctctc tctctctctc tctctcaacg atgggaatga
      841 gcctagggcc tctgctcaga aagagctctg ccattaaact actcctcgct accccccccc
      901 cttttaacaa aattgaaata aataacttgt tttaataaa
//
LOCUS       NR_199196                943 bp    RNA     linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus small lysine-rich protein 1, pseudogene 1
            (Smkr1-ps1), transcript variant 1, non-coding RNA.
ACCESSION   NR_199196
VERSION     NR_199196.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2014559.1,
                                           SRR26360172.1647653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000004.1  59569174-59569326
            154-943             JAXUCZ010000004.1  59575878-59576667
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..943
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /note="small lysine-rich protein 1, pseudogene 1"
                     /pseudo
                     /db_xref="GeneID:103692109"
                     /db_xref="RGD:9298384"
     misc_RNA        1..943
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /product="small lysine-rich protein 1, pseudogene 1,
                     transcript variant 1"
                     /pseudo
                     /db_xref="GeneID:103692109"
                     /db_xref="RGD:9298384"
     exon            1..153
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /inference="alignment:Splign:2.1.0"
                     /pseudo
     exon            154..943
                     /gene="Smkr1-ps1"
                     /gene_synonym="Smkr1"
                     /inference="alignment:Splign:2.1.0"
                     /pseudo
ORIGIN      
        1 agagcgctcg acagcgggct gtctgagtgc ctcggggccg agccccggga gtggggtgag
       61 gcaaaccttg tctaccagca tctgcgcctc cgcacaccgc gaaggcgctc aattggaggt
      121 gcggccacgg ccggggcagg cggcaatacg cgggcaggta aaaggaagaa aagaaaaggc
      181 cggggcaagg ccgggaagaa gcagaagcag aagaagccgg aagtagacat cctcagcccg
      241 gcagccatgt tgaacctata ctacatcgct cacaatgttg ccgactgcct gtatctgcgt
      301 ggcttccctt ggccaggcgc tcccaaaggg aaaaggggga aaaaataaga tttaggtggt
      361 agaattcaaa gcatgccttg gtctcaaaga acagaaagta ggagaatgca tttagggtac
      421 ctcaaggact gcgggcaagc gggctctaac agccaagtag aaacatgtag ccactgtact
      481 tttctgtggt aaataatgac aaacattttt atttccacag ctgagccagg caataggtaa
      541 gccactttgt tttttcagaa gtaaccagga aaaccaaacc caagtagttc ataaaggcta
      601 ccctggcatt ggtagtgttt tttttaaata ttatactcat aaatctagac tgaattaaac
      661 cttgttctca gaaggcagct ccaggttgca tgagtcgttt tcttttgtga gagctggctc
      721 agagaagcag agagctcagg cctaacttgt aagcacgttt tctgctgtgg tttggtttgg
      781 ggtctctctc tctctctctc tctctctctc tctctctctc tctctctctc aacgatggga
      841 atgagcctag ggcctctgct cagaaagagc tctgccatta aactactcct cgctaccccc
      901 ccccctttta acaaaattga aataaataac ttgttttaat aaa
//
LOCUS       NR_031892                 95 bp    RNA     linear   ROD 15-APR-2025
DEFINITION  Rattus norvegicus microRNA 146a (Mir146a), microRNA.
ACCESSION   NR_031892
VERSION     NR_031892.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 95)
  AUTHORS   Santos-Gomes,J., Mendes-Ferreira,P., Adao,R., Maia-Rocha,C.,
            Rego,B., Poels,M., Saint-Martin Willer,A., Masson,B.,
            Provencher,S., Bonnet,S., Montani,D., Perros,F., Antigny,F.,
            Leite-Moreira,A.F. and Bras-Silva,C.
  TITLE     Unraveling the Impact of miR-146a in Pulmonary Arterial
            Hypertension Pathophysiology and Right Ventricular Function
  JOURNAL   Int J Mol Sci 25 (15), 8054 (2024)
   PUBMED   39125620
  REMARK    GeneRIF: Unraveling the Impact of miR-146a in Pulmonary Arterial
            Hypertension Pathophysiology and Right Ventricular Function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 95)
  AUTHORS   Han,R., Zhong,H., Zhang,Y., Yu,H., Zhang,Y., Huang,S., Yang,Z. and
            Zhong,Y.
  TITLE     MiR-146a reduces fibrosis after glaucoma filtration surgery in rats
  JOURNAL   J Transl Med 22 (1), 440 (2024)
   PUBMED   38720358
  REMARK    GeneRIF: MiR-146a reduces fibrosis after glaucoma filtration
            surgery in rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 95)
  AUTHORS   Hsu,C.C., Chen,S.Y., Ko,P.Y., Kwan,F.C., Su,W.R., Jou,I.M. and
            Wu,P.T.
  TITLE     MicroRNA-146a gene transfer ameliorates senescence and
            senescence-associated secretory phenotypes in tendinopathic
            tenocytes
  JOURNAL   Aging (Albany NY) 16 (3), 2702-2714 (2024)
   PUBMED   38309291
  REMARK    GeneRIF: MicroRNA-146a gene transfer ameliorates senescence and
            senescence-associated secretory phenotypes in tendinopathic
            tenocytes.
REFERENCE   4  (bases 1 to 95)
  AUTHORS   Li,Z., Liu,G. and Huang,H.
  TITLE     Silencing of long non-coding RNA SOX2-overlapping transcript
            relieves myocardial ischemia/reperfusion injury through
            up-regulating miRNA-146a-5p
  JOURNAL   Gen Physiol Biophys 42 (2), 191-199 (2023)
   PUBMED   36896948
  REMARK    GeneRIF: Silencing of long non-coding RNA SOX2-overlapping
            transcript relieves myocardial ischemia/reperfusion injury through
            up-regulating miRNA-146a-5p.
REFERENCE   5  (bases 1 to 95)
  AUTHORS   Li,Z., Liu,G. and Huang,H.
  TITLE     Silencing of Long noncoding RNA SOX2-OT relieves myocardial
            ischemia/reperfusion injury through up-regulating microRNA-146a-5p
  JOURNAL   Bratisl Lek Listy 124 (2), 143-150 (2023)
   PUBMED   36598302
  REMARK    GeneRIF: Silencing of Long noncoding RNA SOX2-OT relieves
            myocardial ischemia/reperfusion injury through up-regulating
            microRNA-146a-5p.
REFERENCE   6  (bases 1 to 95)
  AUTHORS   Xu,T., Zhu,Y., Wei,Q.K., Yuan,Y., Zhou,F., Ge,Y.Y., Yang,J.R.,
            Su,H. and Zhuang,S.M.
  TITLE     A functional polymorphism in the miR-146a gene is associated with
            the risk for hepatocellular carcinoma
  JOURNAL   Carcinogenesis 29 (11), 2126-2131 (2008)
   PUBMED   18711148
REFERENCE   7  (bases 1 to 95)
  AUTHORS   Landgraf,P., Rusu,M., Sheridan,R., Sewer,A., Iovino,N., Aravin,A.,
            Pfeffer,S., Rice,A., Kamphorst,A.O., Landthaler,M., Lin,C.,
            Socci,N.D., Hermida,L., Fulci,V., Chiaretti,S., Foa,R.,
            Schliwka,J., Fuchs,U., Novosel,A., Muller,R.U., Schermer,B.,
            Bissels,U., Inman,J., Phan,Q., Chien,M., Weir,D.B., Choksi,R., De
            Vita,G., Frezzetti,D., Trompeter,H.I., Hornung,V., Teng,G.,
            Hartmann,G., Palkovits,M., Di Lauro,R., Wernet,P., Macino,G.,
            Rogler,C.E., Nagle,J.W., Ju,J., Papavasiliou,F.N., Benzing,T.,
            Lichter,P., Tam,W., Brownstein,M.J., Bosio,A., Borkhardt,A.,
            Russo,J.J., Sander,C., Zavolan,M. and Tuschl,T.
  TITLE     A mammalian microRNA expression atlas based on small RNA library
            sequencing
  JOURNAL   Cell 129 (7), 1401-1414 (2007)
   PUBMED   17604727
REFERENCE   8  (bases 1 to 95)
  AUTHORS   Watanabe,T., Takeda,A., Tsukiyama,T., Mise,K., Okuno,T., Sasaki,H.,
            Minami,N. and Imai,H.
  TITLE     Identification and characterization of two novel classes of small
            RNAs in the mouse germline: retrotransposon-derived siRNAs in
            oocytes and germline small RNAs in testes
  JOURNAL   Genes Dev 20 (13), 1732-1743 (2006)
   PUBMED   16766679
REFERENCE   9  (bases 1 to 95)
  AUTHORS   Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and
            Enright,A.J.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
   PUBMED   16381832
REFERENCE   10 (bases 1 to 95)
  AUTHORS   Miska,E.A., Alvarez-Saavedra,E., Townsend,M., Yoshii,A., Sestan,N.,
            Rakic,P., Constantine-Paton,M. and Horvitz,H.R.
  TITLE     Microarray analysis of microRNA expression in the developing
            mammalian brain
  JOURNAL   Genome Biol 5 (9), R68 (2004)
   PUBMED   15345052
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from JAXUCZ010000010.1.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000010.1  28349996-28350090   c
FEATURES             Location/Qualifiers
     source          1..95
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..95
                     /gene="Mir146a"
                     /gene_synonym="rno-mir-146a"
                     /note="microRNA 146a"
                     /db_xref="GeneID:100314241"
                     /db_xref="miRBase:MI0000919"
                     /db_xref="RGD:2325382"
     precursor_RNA   1..95
                     /gene="Mir146a"
                     /gene_synonym="rno-mir-146a"
                     /product="microRNA 146a"
                     /db_xref="GeneID:100314241"
                     /db_xref="miRBase:MI0000919"
                     /db_xref="RGD:2325382"
     exon            1..95
                     /gene="Mir146a"
                     /gene_synonym="rno-mir-146a"
                     /inference="alignment:Splign:2.1.0"
     ncRNA           17..38
                     /ncRNA_class="miRNA"
                     /gene="Mir146a"
                     /gene_synonym="rno-mir-146a"
                     /product="rno-miR-146a-5p"
                     /db_xref="miRBase:MIMAT0000852"
                     /db_xref="GeneID:100314241"
                     /db_xref="miRBase:MI0000919"
                     /db_xref="RGD:2325382"
     ncRNA           52..72
                     /ncRNA_class="miRNA"
                     /gene="Mir146a"
                     /gene_synonym="rno-mir-146a"
                     /product="rno-miR-146a-3p"
                     /db_xref="miRBase:MIMAT0017132"
                     /db_xref="GeneID:100314241"
                     /db_xref="miRBase:MI0000919"
                     /db_xref="RGD:2325382"
ORIGIN      
        1 tgtgtatcct cagctctgag aactgaattc catgggttat agcaatgtca gacctgtgaa
       61 gttcagttct ttagctggga tagctctatc gtcat
//
LOCUS       NM_001438195            2766 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 5, mRNA.
ACCESSION   NM_001438195
VERSION     NM_001438195.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2766)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2766)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2766)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2766)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.2133.1,
                                           SRR26643290.2961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000001.1  162082718-162082764 c
            48-326              JAXUCZ010000001.1  162081503-162081781 c
            327-2766            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2766
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..47
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     exon            48..326
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    218..220
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            327..2766
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1396
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425124.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     335..385
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     386..1393
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    512..574
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    521..592
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    521..592
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    557..559
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <587..>1252
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <587..>1252
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    590..655
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    602..664
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    602..664
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    662..727
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    665..733
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    665..733
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    731..796
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    734..811
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    734..811
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    746..748
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    812..892
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    812..892
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    812..874
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    890..955
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    893..949
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    893..949
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    905..907
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    956..1027
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    956..1027
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    956..1018
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    1025..1093
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    1028..1102
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1028..1102
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1100..1165
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    1103..1177
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1103..1177
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1175..1240
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    1178..1249
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1178..1249
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtt agaaaggcca
       61 cggtttgcct gcatccggcc tgcttgtggc ccctgtccct ggttgggctg tgatgagaag
      121 aggccttcca cacactagtt tcgaaaggca cgccaatggc ccacgtagga tacgggcgtg
      181 tggctgaaac ccgttgagat tcggtcactg ttgtggatga agtgagaaga actctatccc
      241 tcgggagcgg agcgcacaag tggtggtgac cagcgtggcg agcttagctg aaagcggctc
      301 ccgcccacac ttggccgggc ccagaggtgt caccatgttg tgcaccctgt tcctgctact
      361 gctggccctg ggcacagtgc agacaactcg gccatgtttc cctggctgcc agtgtgagga
      421 agagacgttt ggcctctttg acagtttcag cctgatccga gtggactgca gcagcctggg
      481 cccccacatt gtgcctgtgc ccatccctct ggacacagcc cacctggacc tgtcttccaa
      541 ccggctagaa accgtgaatg agtcagtcct gggagggcca ggctatacca cactggctgg
      601 cctggatctc agtcacaacc tcctcaccag catcacgccc actgccttct cccgccttcg
      661 ctacctggag tcactggacc tcagtcacaa tggcctggca gccctgccag cagaggtttt
      721 caccagctcc cccttgagtg atatcaacct gagccataat cgacttagag aggtctcaat
      781 atctgccttc accacccaca gccaggggcg ggcactgcac gtggacctat cccacaatct
      841 tatccaccgc ctgctcccct atccagccag ggccagcctg tccgcaccta ccattcagag
      901 cctgaacctg tcctggaacc ggctccgagc cgtgcccaat ctccgagacc tacccctgcg
      961 ttacctgagc ctggatggga accctctggc taccatcaac ccaggcgcct tcatggggct
     1021 ggcgggcctc acccaccttt cactggcaag cctacagggt atcctccagc taccacccca
     1081 tggcttccga gagctcccag gccttcaggt cctggacttg tctggtaacc ccaagctcaa
     1141 gtgggcagga gccgaggtat tttcaggcct gggtttgctg caagaactag acctgtctgg
     1201 ctccagcctg gtgcccctgc ctgagacgct gctacatcac ctccctgctt tacagagtgt
     1261 cagtgtaggc caagatgtgc agtgccggcg tctggtacgg gagggtgcct accaccgcca
     1321 acccggttcc agccctaagg tagtcctgca ctgtggagac acccaggaat ctgccagggg
     1381 cccagacatc ttgtgacgaa tggtgtggcc tgaggccact tgacagactg ctgtcctggg
     1441 cttgctcagg tccccactaa tattttaatg tgccaatgcc tgtggagtgt ctacaggtct
     1501 aagtggcagc catctcagtg aagatgtggg ccaaggatag ttttcatacc tagggcctat
     1561 acccaataac agaatctgcc cgcttgtctc agcggctcac ttccctgagc tatgagcaaa
     1621 gggacttcga tgccaaacca gactttggtc ccttcctgag ccctgcccca gttatctcta
     1681 agtgccttcc cttttgccca gactgacctg acccatgatg taaggaccgt aggggagcac
     1741 caccactgca aaggctgact aaggtctgtt gggctaaagg tctctttgag cccagtgtct
     1801 atagtcacac cttctttgct ctgggcccag gaggcctact tcttcttttt ctcgtggaat
     1861 cctggaatct taaagataaa agaacctaga aagaaaatca aacccatttt ccttgtgggg
     1921 cagatggtaa tatgggactg agaacagcaa acctggggtc ttggagagga gcccagcctc
     1981 ctgttgaggt tgagagctct gtcaccctcc cttcccctgc tgggtaccct gttactattg
     2041 tctgtactgt tttccattgt gcccagcagt agcaacaaca aggtcacaga ggtgggaact
     2101 ctaggtccag tggccagctt atggtgtgag cgtagtcagt ccccctttca gagcctcagg
     2161 aagcttggag cacctcagtc tcaagcctgt cagttcctta ctctgggatg acccccaaca
     2221 tcaagactgg aaacatacac attctcccca gggacacagt cttaagatgc ttttctaaga
     2281 agtcaatgca gttgtgacca tgtggccatg agctccaagg gactcgtggg cttggtgtcc
     2341 atgggccgga gcccaaagac ccgcttcccc ctccaagagt atggcagaaa gggtctccca
     2401 tgcacattgt gctccccgcc agggccacat ctcagctctc cagctctgga ttctttcttc
     2461 tgttttcatt ttatgagtcg ttgtcttttt taaaatgaac tgtttaaccc ccacctctgc
     2521 tggccagggg atggaaagga agataaatgt atttgttcgc ttttgtaaga ctctgttctg
     2581 ggtgtgggct ggggatcttg ggaagaagcc agttggctat cagtaaccat gtgggcattg
     2641 gggctggtcc ctgggatgct caaaagtcag tgagagctct gtcttctcac actagcccag
     2701 cccagcccac cccgtgactg gtccttggtt taataaacac atgtaagagc tctttccatc
     2761 actgga
//
LOCUS       NM_001438218            3176 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 5, mRNA.
ACCESSION   NM_001438218
VERSION     NM_001438218.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.359589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093043 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              JAXUCZ010000001.1  191913797-191914936 c
            1141-1804           JAXUCZ010000001.1  191907790-191908453 c
            1805-3176           JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3176
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..1140
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1137..1139
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     exon            1141..1804
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             1158..3017
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425147.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    1227..1289
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1227..1289
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1350..2414
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1350..2414
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1413..1475
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1413..1475
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1497..1559
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1497..1559
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1581..1643
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1581..1643
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1665..1727
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1665..1727
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1749..1811
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1749..1811
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1833..1895
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1833..1895
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1848..1850,1854..1856,1860..1862,1866..1871,
                     1878..1883,1890..1892,1932..1934,1938..1940,1950..1955,
                     1962..1967,1974..1976,2016..2018,2022..2024,2028..2030,
                     2034..2039,2046..2051,2058..2060)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1848..1850,1854..1856,1860..1862,1866..1871,
                     1878..1883,1890..1892,1932..1934,1938..1940,1950..1955,
                     1962..1967,1974..1976,2016..2018,2022..2024,2028..2030,
                     2034..2039,2046..2051,2058..2060)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1899..2951
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1899..2951
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1917..1979
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1917..1979
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2001..2063
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2001..2063
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2085..2147
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2085..2147
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2169..2231
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2169..2231
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2253..2315
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2253..2315
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2337..2399
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2337..2399
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2709..2771
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2709..2771
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2724..2726,2730..2732,2736..2738,2742..2747,
                     2754..2759,2766..2768,2808..2810,2814..2816,2826..2831,
                     2838..2843,2850..2852,2892..2894,2898..2900,2904..2906,
                     2910..2915,2922..2927,2934..2936)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2724..2726,2730..2732,2736..2738,2742..2747,
                     2754..2759,2766..2768,2808..2810,2814..2816,2826..2831,
                     2838..2843,2850..2852,2892..2894,2898..2900,2904..2906,
                     2910..2915,2922..2927,2934..2936)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2793..2855
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2793..2855
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2877..2939
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2877..2939
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1805..3176
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcctaaag aacgccattt tgcaggcctt tgtcctgttc tggatcctct gtccattcat
       61 ttcttcagtc cttccttctt cattcattct gtcctgttcc gctcgccgaa gccacgttat
      121 cctagggttt agtcccaaat gagtcagcat acagccccgc tctgcgggag ctgcctgtct
      181 ggcgaggaca cccgcacaaa cacggttgca gagagcgagg aacgctgggt ttctgcaggt
      241 cttgtccctc ctcagagagt ctggtaggcc ctacaccctg caaaatccca tatgcttcag
      301 ggactccatt ccactgaaga aattgaggcc cctagctcta cgcatccctc atttttactg
      361 ctcgttaaat attcttgtgg ggaatggagt attggaagca tgcaagtatc ctcccgtggg
      421 agaaggaaaa cgagggctgg ctcctgggca aaggaaattg catatggagg tggcaaagtt
      481 tgtgaattgt tgatggagct tagactcctg accagagagg acactgctgt agaaactgag
      541 ggtggaaaaa tgggatcatg ttgtgagctg actggttgtt aggcctagga catcattaaa
      601 cgttcaccac aacacaattt catcaattca ccgaaaggct caaggtttgt ggggcttgta
      661 tgttggctta tttgaagctt gtatgtaggt gcctttctta ttgtttcaac cacacctgtg
      721 ctgctcccca aaccaccccg atttaggggg caccgagtct cattaactta aagtaagata
      781 tcattctcct cattgggttt tatcacacag taaacaaatt ggagtactag tgtgatactt
      841 gaaccctgtg accgtgtaag aacggggcat ttcagttaaa tagttggtga ctgactctca
      901 cagactccta tggtggaaga ggcagaggct atagacctcg gcgtgaattc caccagtttg
      961 cttttggtca ccagttttgg aataacaagg gtatagaaca aagttctcag gaccctagtg
     1021 ctggaggtga aaaattaagg cccaaatatt aaaatgtgct agtgctaata aagcagtcgt
     1081 caaggggaca gatggcagaa actttggtat ctgactactt ggcttcaaat accagctgag
     1141 gtctactcac cgaggccatg gaagtggagg ctgcagaggc caagtcccca ggcccctgct
     1201 acaagcgctc tggccgccgt tataagtgcc tgttttgtac aaagacattt ccaaatgctc
     1261 ccagggcagc ccgccatgct gctacacata caactacaga ctgcacagag gaggtgaatg
     1321 aggtccagcc gaaggtggat gcagagccca aggctgagga agccagtgga gacaaggtat
     1381 ctgggtcagt agccaagccc cggccctatg cttgccctct gtgccccaag gcctacaaga
     1441 cagctcctga gctacgcagc catggacgca gccacactgg tgagaagccc ttcccgtgcc
     1501 cagagtgcgg ccgccgtttc atgcagccag tgtgcctgcg tgtgcacctg gcctcacacg
     1561 ctggtgagct gcctttccga tgcacacact gccccaaggc ttatggtaca ctctctaaac
     1621 taaagatcca ccagcgtggg cacacaggcg agcggcccta tgcctgtact gactgcggca
     1681 agagctttgc tgatccttca gtgttccgca agcatcggcg cacgcatgca ggcctgcgcc
     1741 cctacagctg cgagcgctgc ggcaaggcct atgctgagct gaaggactta cgcaaccacg
     1801 aaaggtccca cacgggtgag cgccccttcc tctgctcaga gtgtggtaaa agcttctctc
     1861 gatcctcttc cctcacatgc catcagcgta tccatgcagc ccagaaaccc tatcgctgcc
     1921 cggcttgtgg taagggcttc acacagctca gctcttacca aagccatgag cgcacacatt
     1981 caggcgaaaa gcccttcctg tgccctcggt gtggccgcat gttctctgat ccctcgagct
     2041 tccgccgcca ccagcgggca catgagggtg taaagcctta ccgctgtgag aaatgtggca
     2101 aggacttccg gcagccagct gacctggcca tgcaccgtcg agtacacacc ggcgaccgac
     2161 ccttcaagtg cctgcagtgt gacaagactt ttgtggcttc ctgggacctc aagcggcatg
     2221 cattggtaca ctcaggacag cggccgttcc gctgtgagga gtgtgggcga gcatttgctg
     2281 agcgagctag ccttacaaag cacagccgca tgcactctgg cgagcgtcct ttccactgta
     2341 atgcctgcgg gaaatccttt gtggtgttat ccagcctcag gaagcatgag cgcacccata
     2401 gaagcaacga gactacggga gctgcccccc agcaggagtt ggtactggga ctagcactgc
     2461 ctgtaggtgt cgtaggtgag ggctcagctg cccctgtggc aggtgcaggg ataggggatg
     2521 ctccagcagg gctgctaggg ttaccgcctg agtctggtag tgtagtggcc acacagtggc
     2581 aagtggtggg catgactgta gagcatgtgg agtgccagga tgctggcgtt ggcgaagctc
     2641 ctagtaccct gggagatgca ggagaggtgg gtggggagga gactgatgag aagcccccac
     2701 agtttgtgtg tcgagagtgc aaagaaactt tctccacact gacattgcta cgcaggcatg
     2761 aacgctcaca cccagagctc cggccctttc cctgcaccca gtgtggtaag agcttctcag
     2821 acagggctgg gcttcgtaag catagccgca cccacagctc tgtacgcccc tactcctgtt
     2881 cccaatgtcc taaagctttc ctgagtgcca gtgatctgcg caaacatgaa cgcacccacc
     2941 ctgtgcccat cgggaccccc atacccctgg aaccccttgt ggctctgcta ggaatgccag
     3001 aagaagggtc agcctgaagt ttatagatct ccactacact cccagaaggc catccctagt
     3061 ctccaaaccc ctgcctctgg gcagctagct cagttctcgt ccactaagag ctgtggacag
     3121 tggaagctgg tagcatttgt gagaggtact cattaaagca ttggctttga taccaa
//
LOCUS       NM_001438140            1803 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 7,
            mRNA.
ACCESSION   NM_001438140 XM_006229106
VERSION     NM_001438140.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229106.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3151.1,
                                           SRR26360181.756654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000001.1  105127650-105127772
            124-156             JAXUCZ010000001.1  105128090-105128122
            157-208             JAXUCZ010000001.1  105128567-105128618
            209-347             JAXUCZ010000001.1  105129353-105129491
            348-485             JAXUCZ010000001.1  105130305-105130442
            486-653             JAXUCZ010000001.1  105130564-105130731
            654-826             JAXUCZ010000001.1  105131624-105131796
            827-1144            JAXUCZ010000001.1  105132438-105132755
            1145-1257           JAXUCZ010000001.1  105133588-105133700
            1258-1372           JAXUCZ010000001.1  105134128-105134242
            1373-1471           JAXUCZ010000001.1  105134333-105134431
            1472-1643           JAXUCZ010000001.1  105135522-105135693
            1644-1803           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1803
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..123
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    98..100
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            124..156
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..208
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..347
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1777
                     /gene="Tulp2"
                     /note="isoform 7 is encoded by transcript variant 7;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 7"
                     /protein_id="NP_001425069.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQA
                     HLPSGAHSALVTMSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEE
                     VTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTE
                     NSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGD
                     GDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFP
                     SYYLYLEAEDGVAVRSSPLGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVR
                     SNVLGTKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGM
                     DSRKQRMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRA
                     SVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    257..>724
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    257..>724
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    1010..1759
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    1010..1759
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            348..485
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..653
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..826
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1144
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1257
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1372
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1471
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1643
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1803
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg gcaagtgcct
       61 gtgggaattc ccttctgaga aagagtccgg ataagtttag agtttcagct tcgctgctag
      121 gccaacgtct caagagaatg aacagtggaa gaaagagacc ttggaggatg aattctctgg
      181 tgtgaggctg cagaagctgg aacaacagcg acagctattt gagaagaagc agcgccggaa
      241 acgccaggag cccctcatgg ttcaggccaa tcctgatgct tccctgaggc accggcgacc
      301 aaggcgtggg gaggagcgct tccagagtga cagcagctgg ggccttggtg ttgggagccc
      361 tttcctccag gagaacgtac cacaggcaca tctgccctca ggggcacaca gtgcccttgt
      421 caccatgagc tatgtcggag atgggagtgg tgagcgggcc cctctactgt cacccagagg
      481 agcagtatac actcggggca atgggcctgc ggtccgccat ctctgctggc tcccagacag
      541 ctccgattca gatgtggagg aagtgaccat ggaagacatt cctgtcatct cccgacctcc
      601 caagacgcac ctggcaaacc gacgcagggg ctggttagcc tccccaggac ccgggatcag
      661 tgaagaggaa gaggttgaac ccaaggatgc cagagttgaa gacaagacac ccagcccaga
      721 cccagaccct acagaaaact ctgatagagt tcatggagac tcggcatcct gcaatatgga
      781 ggaaaacaca gccaaaaaga atatagaaac agcctctggc attggggatg aagacccgga
      841 gaagaaagag gccacagagt ctacagagac aaacaatgcc ctagtggcat ccaaggtctt
      901 gcaaggagat ggtgacacca gtaaccacag tgcttggaac atgacctgcc ccatgcctcg
      961 cactccaggt cctcggctcg gggaggacat ggaagcttac gtgttgctcc ctgcaccccg
     1021 agaacacatg gtgcagtgcc gcatcgtccg aaacaagcat ggagtggaca agggcatgtt
     1081 cccttcctac tacctctacc tggaggcaga ggatggtgta gcagtacgct ccagcccttt
     1141 ggggcatttc cttctggctg ggcggaaaag gaaacgaagc aaaacttcaa attacctcat
     1201 ctccctggac cccaaagaca tgtctcgcaa tgggaacaac tttgtaggca aagttagatc
     1261 taatgtcttg ggcacgaaat tcaccatctt tgataatggg gtgaaccctg agcgtaacta
     1321 ctggattcca gacagtgccc ggatcagaga ggagttggga gttgtatgtt atgagaccaa
     1381 tgtcttggga ttcagggggc ctcggaaaat gaccgtgatc ctcccaggaa tggacagccg
     1441 gaagcagagg atgaaagtac aaccacaaaa tgatcaggat tcaatactga gtcgcgtaca
     1501 gaaaggcgct agacatgggc tgctcctact gcagaacaag gccccatcgt ggagcgacga
     1561 aagcggcgca tacgtactca attttcatgg tcgcgtcacg cgggcttctg tcaagaactt
     1621 ccagatagtg cacccggatg aaccggacca cctggtgctc cagtttggcc gtgtagcacc
     1681 aaacatattc acgatggatt tccgatatcc tctttgcccg ctccaagcct tcgccatctg
     1741 cttatccagt ttcgatggga aactggcgtg tgagtaactg aataaaatac catccctcac
     1801 caa
//
LOCUS       NM_001438144            1570 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant
            11, mRNA.
ACCESSION   NM_001438144
VERSION     NM_001438144.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3164.1,
                                           SRR26360181.1333963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-135              JAXUCZ010000001.1  105128567-105128618
            136-273             JAXUCZ010000001.1  105130305-105130442
            274-441             JAXUCZ010000001.1  105130564-105130731
            442-614             JAXUCZ010000001.1  105131624-105131796
            615-911             JAXUCZ010000001.1  105132438-105132734
            912-1024            JAXUCZ010000001.1  105133588-105133700
            1025-1139           JAXUCZ010000001.1  105134128-105134242
            1140-1238           JAXUCZ010000001.1  105134333-105134431
            1239-1410           JAXUCZ010000001.1  105135522-105135693
            1411-1570           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1570
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..135
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    96..98
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            136..273
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1544
                     /gene="Tulp2"
                     /note="isoform 11 is encoded by transcript variant 11;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 11"
                     /protein_id="NP_001425073.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDV
                     EEVTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDP
                     TENSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQ
                     GDGDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGM
                     FPSYYLYLEAEDGVAHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLG
                     TKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQ
                     RMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNF
                     QIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    798..1526
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    798..1526
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            274..441
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..614
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..911
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1024
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1139
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1238
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1410
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1570
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agagaccttg gaggatgaat tctctggtgt gaggctgcag
      121 aagctggaac aacaggtgtt gggagccctt tcctccagga gaacgtacca caggcacatc
      181 tgccctcagg ggcacacagt gcccttgtca ccatgagcta tgtcggagat gggagtggtg
      241 agcgggcccc tctactgtca cccagaggag cagtatacac tcggggcaat gggcctgcgg
      301 tccgccatct ctgctggctc ccagacagct ccgattcaga tgtggaggaa gtgaccatgg
      361 aagacattcc tgtcatctcc cgacctccca agacgcacct ggcaaaccga cgcaggggct
      421 ggttagcctc cccaggaccc gggatcagtg aagaggaaga ggttgaaccc aaggatgcca
      481 gagttgaaga caagacaccc agcccagacc cagaccctac agaaaactct gatagagttc
      541 atggagactc ggcatcctgc aatatggagg aaaacacagc caaaaagaat atagaaacag
      601 cctctggcat tggggatgaa gacccggaga agaaagaggc cacagagtct acagagacaa
      661 acaatgccct agtggcatcc aaggtcttgc aaggagatgg tgacaccagt aaccacagtg
      721 cttggaacat gacctgcccc atgcctcgca ctccaggtcc tcggctcggg gaggacatgg
      781 aagcttacgt gttgctccct gcaccccgag aacacatggt gcagtgccgc atcgtccgaa
      841 acaagcatgg agtggacaag ggcatgttcc cttcctacta cctctacctg gaggcagagg
      901 atggtgtagc acatttcctt ctggctgggc ggaaaaggaa acgaagcaaa acttcaaatt
      961 acctcatctc cctggacccc aaagacatgt ctcgcaatgg gaacaacttt gtaggcaaag
     1021 ttagatctaa tgtcttgggc acgaaattca ccatctttga taatggggtg aaccctgagc
     1081 gtaactactg gattccagac agtgcccgga tcagagagga gttgggagtt gtatgttatg
     1141 agaccaatgt cttgggattc agggggcctc ggaaaatgac cgtgatcctc ccaggaatgg
     1201 acagccggaa gcagaggatg aaagtacaac cacaaaatga tcaggattca atactgagtc
     1261 gcgtacagaa aggcgctaga catgggctgc tcctactgca gaacaaggcc ccatcgtgga
     1321 gcgacgaaag cggcgcatac gtactcaatt ttcatggtcg cgtcacgcgg gcttctgtca
     1381 agaacttcca gatagtgcac ccggatgaac cggaccacct ggtgctccag tttggccgtg
     1441 tagcaccaaa catattcacg atggatttcc gatatcctct ttgcccgctc caagccttcg
     1501 ccatctgctt atccagtttc gatgggaaac tggcgtgtga gtaactgaat aaaataccat
     1561 ccctcaccaa
//
LOCUS       NM_001438137            1709 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 4,
            mRNA.
ACCESSION   NM_001438137
VERSION     NM_001438137.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1709)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.2274.1,
                                           SRR26643293.3152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-135              JAXUCZ010000001.1  105128567-105128618
            136-274             JAXUCZ010000001.1  105129353-105129491
            275-412             JAXUCZ010000001.1  105130305-105130442
            413-580             JAXUCZ010000001.1  105130564-105130731
            581-753             JAXUCZ010000001.1  105131624-105131796
            754-1050            JAXUCZ010000001.1  105132438-105132734
            1051-1163           JAXUCZ010000001.1  105133588-105133700
            1164-1278           JAXUCZ010000001.1  105134128-105134242
            1279-1377           JAXUCZ010000001.1  105134333-105134431
            1378-1549           JAXUCZ010000001.1  105135522-105135693
            1550-1709           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1709
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1709
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1683
                     /gene="Tulp2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 4"
                     /protein_id="NP_001425066.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MDREGPRGPRRGTSQENEQWKKETLEDEFSGVRLQKLEQQRQLF
                     EKKQRRKRQEPLMVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQAHL
                     PSGAHSALVTMSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVT
                     MEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENS
                     DRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGD
                     TSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSY
                     YLYLEAEDGVAHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTKFT
                     IFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKV
                     QPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVH
                     PDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    130..>651
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    130..>651
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    937..1665
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    937..1665
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..135
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..274
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..412
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..580
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..753
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1050
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1163
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1278
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1377
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1549
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1709
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agagaccttg gaggatgaat tctctggtgt gaggctgcag
      121 aagctggaac aacagcgaca gctatttgag aagaagcagc gccggaaacg ccaggagccc
      181 ctcatggttc aggccaatcc tgatgcttcc ctgaggcacc ggcgaccaag gcgtggggag
      241 gagcgcttcc agagtgacag cagctggggc cttggtgttg ggagcccttt cctccaggag
      301 aacgtaccac aggcacatct gccctcaggg gcacacagtg cccttgtcac catgagctat
      361 gtcggagatg ggagtggtga gcgggcccct ctactgtcac ccagaggagc agtatacact
      421 cggggcaatg ggcctgcggt ccgccatctc tgctggctcc cagacagctc cgattcagat
      481 gtggaggaag tgaccatgga agacattcct gtcatctccc gacctcccaa gacgcacctg
      541 gcaaaccgac gcaggggctg gttagcctcc ccaggacccg ggatcagtga agaggaagag
      601 gttgaaccca aggatgccag agttgaagac aagacaccca gcccagaccc agaccctaca
      661 gaaaactctg atagagttca tggagactcg gcatcctgca atatggagga aaacacagcc
      721 aaaaagaata tagaaacagc ctctggcatt ggggatgaag acccggagaa gaaagaggcc
      781 acagagtcta cagagacaaa caatgcccta gtggcatcca aggtcttgca aggagatggt
      841 gacaccagta accacagtgc ttggaacatg acctgcccca tgcctcgcac tccaggtcct
      901 cggctcgggg aggacatgga agcttacgtg ttgctccctg caccccgaga acacatggtg
      961 cagtgccgca tcgtccgaaa caagcatgga gtggacaagg gcatgttccc ttcctactac
     1021 ctctacctgg aggcagagga tggtgtagca catttccttc tggctgggcg gaaaaggaaa
     1081 cgaagcaaaa cttcaaatta cctcatctcc ctggacccca aagacatgtc tcgcaatggg
     1141 aacaactttg taggcaaagt tagatctaat gtcttgggca cgaaattcac catctttgat
     1201 aatggggtga accctgagcg taactactgg attccagaca gtgcccggat cagagaggag
     1261 ttgggagttg tatgttatga gaccaatgtc ttgggattca gggggcctcg gaaaatgacc
     1321 gtgatcctcc caggaatgga cagccggaag cagaggatga aagtacaacc acaaaatgat
     1381 caggattcaa tactgagtcg cgtacagaaa ggcgctagac atgggctgct cctactgcag
     1441 aacaaggccc catcgtggag cgacgaaagc ggcgcatacg tactcaattt tcatggtcgc
     1501 gtcacgcggg cttctgtcaa gaacttccag atagtgcacc cggatgaacc ggaccacctg
     1561 gtgctccagt ttggccgtgt agcaccaaac atattcacga tggatttccg atatcctctt
     1621 tgcccgctcc aagccttcgc catctgctta tccagtttcg atgggaaact ggcgtgtgag
     1681 taactgaata aaataccatc cctcaccaa
//
LOCUS       NM_001438202            2508 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), transcript
            variant 5, mRNA.
ACCESSION   NM_001438202 XM_039078166
VERSION     NM_001438202.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2508)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2508)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2508)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2508)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039078166.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1964512.1,
                                           SRR26643292.3155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000001.1  168148669-168148844 c
            177-652             JAXUCZ010000001.1  168141182-168141657 c
            653-748             JAXUCZ010000001.1  168139744-168139839 c
            749-908             JAXUCZ010000001.1  168138077-168138236 c
            909-931             JAXUCZ010000001.1  168135410-168135432 c
            932-1032            JAXUCZ010000001.1  168134230-168134330 c
            1033-1059           JAXUCZ010000001.1  168133975-168134001 c
            1060-2508           JAXUCZ010000001.1  168132277-168133725 c
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2508
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..176
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            177..652
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            653..748
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            749..908
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    867..869
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="upstream in-frame stop codon"
     CDS             891..1697
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 5;
                     tripartite motif-containing protein 5"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform 2"
                     /protein_id="NP_001425131.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MSILSRGVENTIKRSHTFSMRKPKTIPKEQRRVFRAPDLQGMLQ
                     VLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARPTENCHAGVLGY
                     PAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPLFRLNLSNDSHS
                     RLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLMVRPCRVGIFLD
                     CAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICWPDS"
     misc_feature    1029..1682
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     misc_feature    1029..1682
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            909..931
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1032
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1059
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..2508
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccagcg ctcaaacttt ggttcctctt agagtggggt cttaagtatc ttgaaattct
       61 ggattagcga gttaattttc tgtgatttac gaattctcgg tgtctgaaag ccggtggaac
      121 aattttaggg agcaaagttt tgaggacttt ggaaggaaaa cattgctttt gcttgggcac
      181 ctgagcagac gtgtgaggag tcagtagagt cagacacagg atcacagcaa ctatggcttc
      241 agaattcgtg atgaatttaa aagaggaggt gacctgtcct atctgcctgg acctgatggt
      301 agaacctgtg agtggagatt gtggtcacag cttctgccaa gcctgcatca cgctgaacta
      361 tgaatccagc aaatgcaatc aggatgagtt catttgccct gtgtgccgag ttagttacct
      421 gtttaagaac ctgaggccca atcgacatgt ggccaacata gtgcagaggc tcaaagagtt
      481 caagtccagc ccagaagagg agccgaaggt gctttcttgt gcaaggcatg gagagaaact
      541 ccagctcttc tgtaagaagg acatgatgcc catctgctgg ctttgtgagc gatctcagga
      601 gcaccgtgga caccaaacag ttctcattga agaggtggtc caggagtata aggagaagct
      661 gcaggcagct ctgcaaaagc tgatggcaga caagaaagaa tttgagaact ggaaagatga
      721 ccttcaaaag gagagaactt actggcagaa tcaaatacag aaagatgtgg aaaatgtcca
      781 gtcagagttt aaaggaatga gagatatcat ggactctgag gagaagaagg aattgcagaa
      841 gctgatgcaa gagaaggaag acattatgag cagcctggaa gagtctgaaa atgagtattc
      901 tcagcagagg tgtagagaac accataaaac ggagtcatac tttttcgatg aggaagccca
      961 aaaccatccc caaggaacaa agaagagtgt tccgagcccc tgatctgcaa ggcatgctgc
     1021 aagtgttaca agaggtcaca gaggcccaac gctactgggt tcaagtgacg ctggttgaaa
     1081 gcaacaatcc aaacattttc attaccgccg acaaaagaca gatacgatat gaagaccacc
     1141 aagcaagaca ttttgcccgt ccgactgaaa actgtcatgc aggtgtcctg ggatacccag
     1201 ctatccaatc aggaaaacac tactgggaag tagatgtgtc tggaaaaggt tcttgggttc
     1261 tgggattaag tgatggaagc tacctcttta atccaatatt tcgttcaaat gcagaaagac
     1321 ccccaaaccc ccccttattt cgtttgaatc ttagtaatga ttcacattct cgtttgagtc
     1381 ttagtaatga ttcacattat caacctaaat atggcttctg ggttataggg ctgtggggaa
     1441 attctgtgta taatgctttt gaggagtgta cgttcacagg caagcccagt gtgttgaccc
     1501 tctctctgat ggtccgaccc tgtcgtgtcg gtattttcct cgactgtgca gctggcaccc
     1561 tctcgtttta caatatttcc aaccatggca ctcttatcta cagattctgt gcaggttcct
     1621 ttcctgatag ggtttttcca tattttaacc ccatgggaag ttcagagcca ttgacaatat
     1681 gctggccaga ctcttaatct tcactgtctc tgtgcatggt ctctggtcct gatgtgtatg
     1741 tcatgtgcct gagctcatca gcactatttt atcgttttgt tcatgtctct aatctttcat
     1801 tggaaaatat attcatttct ctaggccata ttctcagttt cttggggtat tttttgtctt
     1861 tgttttgttt tgtttttagg tgagactaac aaatcacttc ccatatagtc aaggacaaat
     1921 gtctagtgct cactgcgtaa gataacaccg atgcaaaatt cctcttattc ttcatgccag
     1981 agatggaagg caaggccttg tgcacggtga ggatgtgctc caccgctgag ctgtttgctt
     2041 cagctgtcat gtccctataa cctcattcgg cccatcaatg aaagattaaa gaaggttctt
     2101 cgacaacttg tctattcatg ctgaaaatta tatataggag tctctgctta agaaatgcac
     2161 cctgagctgt aggccaaaga atgaaggaga agcatcacaa gaagccttat cactgtgact
     2221 aaattaagtg atcattaaga ctgtgcatca gtcttgcctg ggagctcata cctgccatcc
     2281 tgcatctggg aagttgtggc aggaagattg ctgtgtattt gaagccaccc ttgtatagag
     2341 ttaagagcct gcttaaaaaa aataatcaag aatatgtata aaaaccacta ctctattttg
     2401 ttctaagaaa tagaataact agatttcaga attgcagggt ttgggtcgtt ttcacaattt
     2461 gtaaataaat gtttactaaa aataaatgtt aacttcatag ctgtccaa
//
LOCUS       NM_001438239            5652 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 3 (Dcun1d3), transcript variant 4, mRNA.
ACCESSION   NM_001438239 XM_063263634
VERSION     NM_001438239.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5652)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063263634.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.3630.1,
                                           SRR26360194.2275618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  183715963-183716164 c
            203-739             JAXUCZ010000001.1  183681017-183681553 c
            740-5652            JAXUCZ010000001.1  183674364-183679276 c
FEATURES             Location/Qualifiers
     source          1..5652
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..5652
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
     exon            1..202
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            203..739
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    222..224
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="upstream in-frame stop codon"
     CDS             309..1223
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; DCN1,
                     defective in cullin neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_001425168.1"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
                     /translation="MGQCVTKCKNPSSTLGSKNGDRDPSSKSHSRRGASHREEQVPPC
                     GKPAGDILVNGTKKAEAATEACQLPTSSGDAGRESKTNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREVEGRGALSSGPEGLCPEEQT"
     misc_feature    309..569
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    798..1136
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    798..1136
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    1161..1220
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            740..5652
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcaaatca gcgccttgtc tggactggtc cctctggaag aagaggctgt gaggggagcc
       61 tgtggcttgt caagcgcaag gctcagaaaa cttacctact gtccctgcct gtccatcgcc
      121 agcacccctc aatcccgggt ctggggacct ggggctgtag atccccgggg agggtctgca
      181 gactctgagc tgaaagtcca gggttggctg gctcctctaa ctgatggcat gttgaagtac
      241 atggaccagt ggcagcgaag ggatctgatc cagagtgggc cactctagaa ggccaggcta
      301 caatcaccat gggccagtgt gtcaccaaat gcaagaatcc ttcatcaacc ttgggcagca
      361 agaatggaga ccgggacccc agcagcaagt cacacagcag gcggggggct agccaccgtg
      421 aggaacaggt gccaccttgt ggcaaaccag ctggggatat tcttgtcaat gggaccaaga
      481 aagcagaggc tgccaccgag gcctgccagc tgccaacttc ttctggagat gcagggaggg
      541 agtccaagac caatgctgag gagtcttcct tgcagaggtt ggaagaactg ttcaggcgct
      601 ataaggatga gcgggaggat gcaattttgg aggaaggcat ggagcgcttt tgcaatgacc
      661 tatgtgttga tcctacggag tttcgagtgc tgctcttggc ctggaagttc caggctgcta
      721 ccatgtgcaa attcaccagg aaggagtttt ttgacggctg taaagcaata agtgcagaca
      781 gcattgatgg gatctgtgca cgtttcccta gcctcttaac agaagccaaa caagaagata
      841 aattcaagga tctctaccgg tttacatttc agtttggcct ggactctgaa gaagggcagc
      901 ggtcactgca tcgtgaaata gccattgccc tgtggaaatt agtatttaca cagaacaatc
      961 ctccagtatt ggaccagtgg ctaaatttcc taacagagaa cccttcggga atcaagggca
     1021 tctcccggga cacttggaac atgtttctta acttcactca ggtgattggc cccgacctca
     1081 gcaactacag tgaagatgag gcctggccga gtctctttga tacctttgtg gagtgggaaa
     1141 tggagagaag gaaaagagaa gtggaaggga gaggtgcact cagctcaggg cccgagggct
     1201 tgtgtccaga agagcagact tagctgctct gttccaggag cagcactgag gatctgcctg
     1261 ctgccctgca gccaagtgag gaattggacc tttctggaaa ttaccgaaga tccggatatt
     1321 ttctactttc acctttctct gccttgtatt tgaaagggct ctaaaatgct gtatcatgtt
     1381 ttaggcactt tcttcatttt tttttttggg ttattttggt tatttctttt tgggggtggg
     1441 aaatcccccc aaaatatttg aacctggcta catgttgtgt accttttttt gaagccttca
     1501 gatagaataa gcctgccatt tcttgcacaa ctttattaga tttgttttgt ttttgtgggg
     1561 gagggtgtag acccgggttg gggagtggga ctgttaggtt gaattaacat tacaaaatga
     1621 tacagtgcca gatctcagtt ttgcatatta tttttcaggg caggtctgta ctgtgtgtag
     1681 tgctgtttac atggttgaat ttaggttgta ataattattt taaaagattt acacagatat
     1741 gaatatagca gtgttaactg ttagccacat tgcattaatt tccagacagt ttggagctct
     1801 tggagagcca aggccaaggc ccgtcaggag catttgcagt cttgacaccc caccccatcc
     1861 ctttacgcta atttatccaa agccctatct ccctcacttc ctgctcattc cttctctaac
     1921 ctatattgca tttcatgttt aacttatcca tcaacatgct gtacctgtca gtcaagtgag
     1981 cagttttgtt ttgttcgaac acattgtact gaaaaccact taagcattga atgcagagaa
     2041 agcagtgcta cctcagtttt gctggaagta gacttctttg atattttctt tgatgttttt
     2101 gtattttcat gtcataagtg gaaatacttc tttttccccc ttttcatttg ccttggagcc
     2161 aaagtttccg ttgttgtggg tggtgagaaa agtgtgcctg cctgcctgcc tgccagctga
     2221 ccggacagaa agctgtggca tggggctctg ctccagactg cttttcttta gtttttgttg
     2281 agtatcacta gcttacttgt ctggcaagtg cagaagcctg aggctggcct gaactctgcc
     2341 aaacaaatta tccacgtgta ttgaatcatt aaatgtgtgc cctctccctc tttgctgcgc
     2401 ccatgttgtc acttaacccc aggagttatt tattgtcttt tgttagtgtc aggctcacct
     2461 ggggtgacgt gatggctgtt taggtttaca cggccctctg ctctttccct actcccagac
     2521 atgtatatat acatatataa gatatgtata tattttacct tataaaatat atatatacac
     2581 atatatgtat ctatatccct gcgtttgtct gctaaaactg gccatgaaag agggagctgc
     2641 cttcaatctg tagtttaaga agatgccagg gagcatcata aatggaggct gttgtatatt
     2701 aatttagatt tttttcacta aaaagaacat gaatgaattt gctcgcagga aggaggaacc
     2761 agttctctag accccatgct cactctacaa gaccagcttt ggtcaagctg cccctggggc
     2821 ctgaagagct gactatctcc tgcctgttcc attagaggac catcttgata atttcccctt
     2881 aaaaatatcc tcaaaaatgt actggaaggt gggtggcagg agcttgtaca gttcagcttc
     2941 caacatttcg gaacagattt aaaagggaat cttttaataa ataaaagcta caaaaatatt
     3001 tatactcttg atacaatgaa aaagtgtcta ttaaatattt ggaattttct tccttgatta
     3061 gtctgcccca aatcctgggt atgtttctca acctgggtaa gaattgcatg ctttgagttc
     3121 ttcatgagtc ttatagctct gggcacttat ctctataaag atgattattt taggagatga
     3181 cagtcatatt tcctgaagtt ggtattgaca cagggaacat ttttgtaagc ctcacaattg
     3241 tcctttcttg agggatgaga tgatgaaaat cagccacaga cttaagatag tgctggaagg
     3301 cacaagtggc tattgggcca gatgtacccc tttcttctag ctgaaataag agacatcctt
     3361 gagttagaat ctaggagccc agcagtttct gagggcacag ctacatacct ttggataaaa
     3421 gctcaccaaa ccagttagtt gttcctaatt caggattaga agaagtccaa tgagggaaaa
     3481 agcggagtta ggtaagtaag actttctgtc ccagataaga aagggtgggt gtatggcggg
     3541 gaagtgccaa gagagggagt ctgccaaggg ccccatggac tcaaggaact agattccttc
     3601 ccaactgggt agattttttt ttaactgccc agtttctcca accccaatgc ctgcacccca
     3661 acccccagcc atttagaaat tgtgattata tttttaatca tctgttgctg agaaagcaga
     3721 gaaaggaaca gtcagggagg gactctgggt tctctgtgca gtagttttgt tttactgaga
     3781 gactctcagt gaggtgtaca gtttgtagtt aacacttctg ggatacagaa aagcctctgt
     3841 tcactcagcc tcagacaggc ttgctgagaa ctgggtggat gagcagtggc tgggagccaa
     3901 attgcccctc aggtaagcta gctttgtgac ttgggtgatg ggtgatgtgg ggaggtgcga
     3961 tatgtgggtg ccattttgaa attctgcaat gtttaagcat tactacacag aatatgttga
     4021 aaattgctta ctttgggcaa gtgacttttt gagtttctat ggtatttctt tagtaactta
     4081 ttagcaagct ggtatgagat aaaaagttac tttactgaat tctttcccct agtcttcctt
     4141 gccatacttg aatgtatcat tcttaatgac actttgctgt acttctgggg gttgcctcag
     4201 caactctctc ttcactggca gatgtgccaa catgtatgtt gggtccagaa gtctgtatgt
     4261 acccatctta taaagaagtc tccagagctg gctgaaattc caaatttcag ccaaagcttt
     4321 gggccaaggg aaagatagta gaaaatgtgc aaagcagtac tgttcatgtt agatggatgg
     4381 atacagtgaa gaattaagcc tcacacagaa ttagcttgaa acagtactgt cacctagggt
     4441 ctggtctcta ggctagatca ggttatggga ccctataaat tatgtaatta gactatacat
     4501 tggtgggaag ttgctaagat aaagacttgc tcaaaagact aacagcaaaa gatgtgtgta
     4561 ttgaaatgta tagtttgctg tagttcaagt ggagtcttca gtgcagcagg tagacctagt
     4621 tatacagtta tgtatggaat ggaaagcaaa ctactgttaa acggtttttg tctctcccct
     4681 gccaccttct ttagatttct taatctcctg tgtgtgtcag gatggctagt gatgacctga
     4741 acatctataa ctgacaaagg tctacttggg ggactaaagc agtatttagc ttaaatatgt
     4801 gaaagaacaa aattatcaaa agatgttgat taggattatt taaggtcatg tgacattgat
     4861 cttttcttct acgtcatggt tcttgccaca ctcctattct gagtttattt ttttggtaag
     4921 ctgtagttgt agcccataac agtttgacct ggcctaggac tacatgctgg ggatgctcat
     4981 caggacctcc cccccccccc tttttttttt ttcaaagaag gatgcttgag cattgggcac
     5041 agatgctgag gtggtttgac tagctgaagt tctgattcgg gtgttggggc atcatattct
     5101 gtttctcttg ggaacccagc ctgctctcat agatacctac ttctatcaca taccctgagc
     5161 attgccaaaa gaagccattc agcagctgct gtttttctct cagcacaaat atatttgcta
     5221 cagaagaact atcttttctc taatactaat tccccgtcca gtcctcagaa tctgattaac
     5281 tgttcttccc tgctgcactg aatatgttcg agattttaaa gagggaattt gaagcaatag
     5341 gcaaacaggg cttggttgaa ttggtcttgc atatatcctg tcttaagcca atgaggtgat
     5401 gagtccactg ctcatgtgac cctgcacctt tgtggatcct tcttggtttg tgaccagtgt
     5461 acgtttcttg aggttgtaca aacttgacaa aagttaatac ttttgtattc tctgcactgt
     5521 tgcactcttc aaatagcccc ctgaatatta ccttgatata cacatttttg tctttgatgt
     5581 ctacagtatt tttctttttt ttttaaattt gaaggttatc tgctgttgga ttcaataaat
     5641 ttgtttacct aa
//
LOCUS       NM_001438223            2216 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 10, mRNA.
ACCESSION   NM_001438223 XM_039078439
VERSION     NM_001438223.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2216)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039078439.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.296439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000001.1  191915312-191915404 c
            94-175              JAXUCZ010000001.1  191909096-191909177 c
            176-844             JAXUCZ010000001.1  191907790-191908458 c
            845-2216            JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2216
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..93
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            94..175
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     CDS             165..2057
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 2 is encoded by transcript variant 10"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 2"
                     /protein_id="NP_001425152.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEPREGLLTEAMEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPN
                     APRAARHAATHTTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPK
                     AYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAY
                     GTLSKLKIHQRGHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAE
                     LKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLS
                     SYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADL
                     AMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTK
                     HSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVV
                     GEGSAAPVAGAGIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPST
                     LGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSD
                     RAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGM
                     PEEGSA"
     misc_feature    267..329
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    267..329
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(267..269,276..278,315..317,327..329)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(267..269,276..278,315..317,327..329)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    390..1454
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    390..1454
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    453..515
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    453..515
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    537..599
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    537..599
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(537..539,546..548,585..587,597..599)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(537..539,546..548,585..587,597..599)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    621..683
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    621..683
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    705..767
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    705..767
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(705..707,714..716,753..755,765..767)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(705..707,714..716,753..755,765..767)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    789..851
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    789..851
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    873..935
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    873..935
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(873..875,882..884,921..923,933..935)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(873..875,882..884,921..923,933..935)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(888..890,894..896,900..902,906..911,918..923,
                     930..932,972..974,978..980,990..995,1002..1007,1014..1016,
                     1056..1058,1062..1064,1068..1070,1074..1079,1086..1091,
                     1098..1100)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(888..890,894..896,900..902,906..911,918..923,
                     930..932,972..974,978..980,990..995,1002..1007,1014..1016,
                     1056..1058,1062..1064,1068..1070,1074..1079,1086..1091,
                     1098..1100)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    939..1991
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    939..1991
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    957..1019
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    957..1019
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1041..1103
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1041..1103
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1125..1187
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1125..1187
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1209..1271
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1209..1271
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1293..1355
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1293..1355
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1377..1439
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1377..1439
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1749..1811
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1749..1811
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1749..1751,1758..1760,1797..1799,1809..1811)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1749..1751,1758..1760,1797..1799,1809..1811)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1764..1766,1770..1772,1776..1778,1782..1787,
                     1794..1799,1806..1808,1848..1850,1854..1856,1866..1871,
                     1878..1883,1890..1892,1932..1934,1938..1940,1944..1946,
                     1950..1955,1962..1967,1974..1976)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1764..1766,1770..1772,1776..1778,1782..1787,
                     1794..1799,1806..1808,1848..1850,1854..1856,1866..1871,
                     1878..1883,1890..1892,1932..1934,1938..1940,1944..1946,
                     1950..1955,1962..1967,1974..1976)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1833..1895
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1833..1895
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1917..1979
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1917..1979
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            176..844
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            845..2216
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcctagc gcctgcctct ctccgagtgt ccagagctct gtcagcgcta ggcaccaccg
       61 ccgaagctgc ggagcctgcg aaaatcgaac caggtctgcc tttcctgagc atttggagat
      121 cttaaggccg cgggtggacc tgagaaagga atattgtgag agtaatggaa cctagagaag
      181 gtctactcac cgaggccatg gaagtggagg ctgcagaggc caagtcccca ggcccctgct
      241 acaagcgctc tggccgccgt tataagtgcc tgttttgtac aaagacattt ccaaatgctc
      301 ccagggcagc ccgccatgct gctacacata caactacaga ctgcacagag gaggtgaatg
      361 aggtccagcc gaaggtggat gcagagccca aggctgagga agccagtgga gacaaggtat
      421 ctgggtcagt agccaagccc cggccctatg cttgccctct gtgccccaag gcctacaaga
      481 cagctcctga gctacgcagc catggacgca gccacactgg tgagaagccc ttcccgtgcc
      541 cagagtgcgg ccgccgtttc atgcagccag tgtgcctgcg tgtgcacctg gcctcacacg
      601 ctggtgagct gcctttccga tgcacacact gccccaaggc ttatggtaca ctctctaaac
      661 taaagatcca ccagcgtggg cacacaggcg agcggcccta tgcctgtact gactgcggca
      721 agagctttgc tgatccttca gtgttccgca agcatcggcg cacgcatgca ggcctgcgcc
      781 cctacagctg cgagcgctgc ggcaaggcct atgctgagct gaaggactta cgcaaccacg
      841 aaaggtccca cacgggtgag cgccccttcc tctgctcaga gtgtggtaaa agcttctctc
      901 gatcctcttc cctcacatgc catcagcgta tccatgcagc ccagaaaccc tatcgctgcc
      961 cggcttgtgg taagggcttc acacagctca gctcttacca aagccatgag cgcacacatt
     1021 caggcgaaaa gcccttcctg tgccctcggt gtggccgcat gttctctgat ccctcgagct
     1081 tccgccgcca ccagcgggca catgagggtg taaagcctta ccgctgtgag aaatgtggca
     1141 aggacttccg gcagccagct gacctggcca tgcaccgtcg agtacacacc ggcgaccgac
     1201 ccttcaagtg cctgcagtgt gacaagactt ttgtggcttc ctgggacctc aagcggcatg
     1261 cattggtaca ctcaggacag cggccgttcc gctgtgagga gtgtgggcga gcatttgctg
     1321 agcgagctag ccttacaaag cacagccgca tgcactctgg cgagcgtcct ttccactgta
     1381 atgcctgcgg gaaatccttt gtggtgttat ccagcctcag gaagcatgag cgcacccata
     1441 gaagcaacga gactacggga gctgcccccc agcaggagtt ggtactggga ctagcactgc
     1501 ctgtaggtgt cgtaggtgag ggctcagctg cccctgtggc aggtgcaggg ataggggatg
     1561 ctccagcagg gctgctaggg ttaccgcctg agtctggtag tgtagtggcc acacagtggc
     1621 aagtggtggg catgactgta gagcatgtgg agtgccagga tgctggcgtt ggcgaagctc
     1681 ctagtaccct gggagatgca ggagaggtgg gtggggagga gactgatgag aagcccccac
     1741 agtttgtgtg tcgagagtgc aaagaaactt tctccacact gacattgcta cgcaggcatg
     1801 aacgctcaca cccagagctc cggccctttc cctgcaccca gtgtggtaag agcttctcag
     1861 acagggctgg gcttcgtaag catagccgca cccacagctc tgtacgcccc tactcctgtt
     1921 cccaatgtcc taaagctttc ctgagtgcca gtgatctgcg caaacatgaa cgcacccacc
     1981 ctgtgcccat cgggaccccc atacccctgg aaccccttgt ggctctgcta ggaatgccag
     2041 aagaagggtc agcctgaagt ttatagatct ccactacact cccagaaggc catccctagt
     2101 ctccaaaccc ctgcctctgg gcagctagct cagttctcgt ccactaagag ctgtggacag
     2161 tggaagctgg tagcatttgt gagaggtact cattaaagca ttggctttga taccaa
//
LOCUS       NM_001438198            2568 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 8, mRNA.
ACCESSION   NM_001438198 XM_039113208
VERSION     NM_001438198.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039113208.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1637476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680431, SAMN06680442
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000001.1  162082444-162082571 c
            129-2568            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2568
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..128
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    38..40
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            129..2568
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1198
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425127.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     137..187
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     188..1195
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    314..376
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    323..394
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    323..394
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    359..361
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <389..>1054
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <389..>1054
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    392..457
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    404..466
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    404..466
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    464..529
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    467..535
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    467..535
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    533..598
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    536..613
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    536..613
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    548..550
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    614..694
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    614..694
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    614..676
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    692..757
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    695..751
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    695..751
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    707..709
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    758..829
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    758..829
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    758..820
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    827..895
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    830..904
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    830..904
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    902..967
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    905..979
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    905..979
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    977..1042
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    980..1051
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    980..1051
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 acggagccac agcggcgcag ggtccgggga gcaggggtga gggctttcag aagacaaagg
       61 ctctgcttgg gggccgtggg cgtgggccgg cgcctccagg gtctttgtaa gaacacgtgc
      121 atctcacggt gtcaccatgt tgtgcaccct gttcctgcta ctgctggccc tgggcacagt
      181 gcagacaact cggccatgtt tccctggctg ccagtgtgag gaagagacgt ttggcctctt
      241 tgacagtttc agcctgatcc gagtggactg cagcagcctg ggcccccaca ttgtgcctgt
      301 gcccatccct ctggacacag cccacctgga cctgtcttcc aaccggctag aaaccgtgaa
      361 tgagtcagtc ctgggagggc caggctatac cacactggct ggcctggatc tcagtcacaa
      421 cctcctcacc agcatcacgc ccactgcctt ctcccgcctt cgctacctgg agtcactgga
      481 cctcagtcac aatggcctgg cagccctgcc agcagaggtt ttcaccagct cccccttgag
      541 tgatatcaac ctgagccata atcgacttag agaggtctca atatctgcct tcaccaccca
      601 cagccagggg cgggcactgc acgtggacct atcccacaat cttatccacc gcctgctccc
      661 ctatccagcc agggccagcc tgtccgcacc taccattcag agcctgaacc tgtcctggaa
      721 ccggctccga gccgtgccca atctccgaga cctacccctg cgttacctga gcctggatgg
      781 gaaccctctg gctaccatca acccaggcgc cttcatgggg ctggcgggcc tcacccacct
      841 ttcactggca agcctacagg gtatcctcca gctaccaccc catggcttcc gagagctccc
      901 aggccttcag gtcctggact tgtctggtaa ccccaagctc aagtgggcag gagccgaggt
      961 attttcaggc ctgggtttgc tgcaagaact agacctgtct ggctccagcc tggtgcccct
     1021 gcctgagacg ctgctacatc acctccctgc tttacagagt gtcagtgtag gccaagatgt
     1081 gcagtgccgg cgtctggtac gggagggtgc ctaccaccgc caacccggtt ccagccctaa
     1141 ggtagtcctg cactgtggag acacccagga atctgccagg ggcccagaca tcttgtgacg
     1201 aatggtgtgg cctgaggcca cttgacagac tgctgtcctg ggcttgctca ggtccccact
     1261 aatattttaa tgtgccaatg cctgtggagt gtctacaggt ctaagtggca gccatctcag
     1321 tgaagatgtg ggccaaggat agttttcata cctagggcct atacccaata acagaatctg
     1381 cccgcttgtc tcagcggctc acttccctga gctatgagca aagggacttc gatgccaaac
     1441 cagactttgg tcccttcctg agccctgccc cagttatctc taagtgcctt cccttttgcc
     1501 cagactgacc tgacccatga tgtaaggacc gtaggggagc accaccactg caaaggctga
     1561 ctaaggtctg ttgggctaaa ggtctctttg agcccagtgt ctatagtcac accttctttg
     1621 ctctgggccc aggaggccta cttcttcttt ttctcgtgga atcctggaat cttaaagata
     1681 aaagaaccta gaaagaaaat caaacccatt ttccttgtgg ggcagatggt aatatgggac
     1741 tgagaacagc aaacctgggg tcttggagag gagcccagcc tcctgttgag gttgagagct
     1801 ctgtcaccct cccttcccct gctgggtacc ctgttactat tgtctgtact gttttccatt
     1861 gtgcccagca gtagcaacaa caaggtcaca gaggtgggaa ctctaggtcc agtggccagc
     1921 ttatggtgtg agcgtagtca gtcccccttt cagagcctca ggaagcttgg agcacctcag
     1981 tctcaagcct gtcagttcct tactctggga tgacccccaa catcaagact ggaaacatac
     2041 acattctccc cagggacaca gtcttaagat gcttttctaa gaagtcaatg cagttgtgac
     2101 catgtggcca tgagctccaa gggactcgtg ggcttggtgt ccatgggccg gagcccaaag
     2161 acccgcttcc ccctccaaga gtatggcaga aagggtctcc catgcacatt gtgctccccg
     2221 ccagggccac atctcagctc tccagctctg gattctttct tctgttttca ttttatgagt
     2281 cgttgtcttt tttaaaatga actgtttaac ccccacctct gctggccagg ggatggaaag
     2341 gaagataaat gtatttgttc gcttttgtaa gactctgttc tgggtgtggg ctggggatct
     2401 tgggaagaag ccagttggct atcagtaacc atgtgggcat tggggctggt ccctgggatg
     2461 ctcaaaagtc agtgagagct ctgtcttctc acactagccc agcccagccc accccgtgac
     2521 tggtccttgg tttaataaac acatgtaaga gctctttcca tcactgga
//
LOCUS       NM_001024886            5657 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 3 (Dcun1d3), transcript variant 5, mRNA.
ACCESSION   NM_001024886 XM_219389
VERSION     NM_001024886.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced NM_001024886.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097462.1, SRR26360172.162881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000001.1  183716796-183717002 c
            208-744             JAXUCZ010000001.1  183681017-183681553 c
            745-5657            JAXUCZ010000001.1  183674364-183679276 c
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..5657
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
     exon            1..207
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            208..744
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    227..229
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="upstream in-frame stop codon"
     CDS             314..1228
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; DCN1,
                     defective in cullin neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_001020057.1"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
                     /translation="MGQCVTKCKNPSSTLGSKNGDRDPSSKSHSRRGASHREEQVPPC
                     GKPAGDILVNGTKKAEAATEACQLPTSSGDAGRESKTNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREVEGRGALSSGPEGLCPEEQT"
     misc_feature    314..574
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    803..1141
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    803..1141
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    1166..1225
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            745..5657
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtccccc gcgaccggag ccggcttctc catccttaca ctcactcagc gtcactcctg
       61 ccttccccca cccacaggag tcggctggga agaggcggtg ccaggagctc tgccgagcct
      121 tcgccacacc gggctctatc gagcaggtcc cgcaggctag gccgggccaa accaccgggc
      181 ggacagctgt ggcagcatga ggcccaggtt ggctggctcc tctaactgat ggcatgttga
      241 agtacatgga ccagtggcag cgaagggatc tgatccagag tgggccactc tagaaggcca
      301 ggctacaatc accatgggcc agtgtgtcac caaatgcaag aatccttcat caaccttggg
      361 cagcaagaat ggagaccggg accccagcag caagtcacac agcaggcggg gggctagcca
      421 ccgtgaggaa caggtgccac cttgtggcaa accagctggg gatattcttg tcaatgggac
      481 caagaaagca gaggctgcca ccgaggcctg ccagctgcca acttcttctg gagatgcagg
      541 gagggagtcc aagaccaatg ctgaggagtc ttccttgcag aggttggaag aactgttcag
      601 gcgctataag gatgagcggg aggatgcaat tttggaggaa ggcatggagc gcttttgcaa
      661 tgacctatgt gttgatccta cggagtttcg agtgctgctc ttggcctgga agttccaggc
      721 tgctaccatg tgcaaattca ccaggaagga gttttttgac ggctgtaaag caataagtgc
      781 agacagcatt gatgggatct gtgcacgttt ccctagcctc ttaacagaag ccaaacaaga
      841 agataaattc aaggatctct accggtttac atttcagttt ggcctggact ctgaagaagg
      901 gcagcggtca ctgcatcgtg aaatagccat tgccctgtgg aaattagtat ttacacagaa
      961 caatcctcca gtattggacc agtggctaaa tttcctaaca gagaaccctt cgggaatcaa
     1021 gggcatctcc cgggacactt ggaacatgtt tcttaacttc actcaggtga ttggccccga
     1081 cctcagcaac tacagtgaag atgaggcctg gccgagtctc tttgatacct ttgtggagtg
     1141 ggaaatggag agaaggaaaa gagaagtgga agggagaggt gcactcagct cagggcccga
     1201 gggcttgtgt ccagaagagc agacttagct gctctgttcc aggagcagca ctgaggatct
     1261 gcctgctgcc ctgcagccaa gtgaggaatt ggacctttct ggaaattacc gaagatccgg
     1321 atattttcta ctttcacctt tctctgcctt gtatttgaaa gggctctaaa atgctgtatc
     1381 atgttttagg cactttcttc attttttttt ttgggttatt ttggttattt ctttttgggg
     1441 gtgggaaatc cccccaaaat atttgaacct ggctacatgt tgtgtacctt tttttgaagc
     1501 cttcagatag aataagcctg ccatttcttg cacaacttta ttagatttgt tttgtttttg
     1561 tgggggaggg tgtagacccg ggttggggag tgggactgtt aggttgaatt aacattacaa
     1621 aatgatacag tgccagatct cagttttgca tattattttt cagggcaggt ctgtactgtg
     1681 tgtagtgctg tttacatggt tgaatttagg ttgtaataat tattttaaaa gatttacaca
     1741 gatatgaata tagcagtgtt aactgttagc cacattgcat taatttccag acagtttgga
     1801 gctcttggag agccaaggcc aaggcccgtc aggagcattt gcagtcttga caccccaccc
     1861 catcccttta cgctaattta tccaaagccc tatctccctc acttcctgct cattccttct
     1921 ctaacctata ttgcatttca tgtttaactt atccatcaac atgctgtacc tgtcagtcaa
     1981 gtgagcagtt ttgttttgtt cgaacacatt gtactgaaaa ccacttaagc attgaatgca
     2041 gagaaagcag tgctacctca gttttgctgg aagtagactt ctttgatatt ttctttgatg
     2101 tttttgtatt ttcatgtcat aagtggaaat acttcttttt cccccttttc atttgccttg
     2161 gagccaaagt ttccgttgtt gtgggtggtg agaaaagtgt gcctgcctgc ctgcctgcca
     2221 gctgaccgga cagaaagctg tggcatgggg ctctgctcca gactgctttt ctttagtttt
     2281 tgttgagtat cactagctta cttgtctggc aagtgcagaa gcctgaggct ggcctgaact
     2341 ctgccaaaca aattatccac gtgtattgaa tcattaaatg tgtgccctct ccctctttgc
     2401 tgcgcccatg ttgtcactta accccaggag ttatttattg tcttttgtta gtgtcaggct
     2461 cacctggggt gacgtgatgg ctgtttaggt ttacacggcc ctctgctctt tccctactcc
     2521 cagacatgta tatatacata tataagatat gtatatattt taccttataa aatatatata
     2581 tacacatata tgtatctata tccctgcgtt tgtctgctaa aactggccat gaaagaggga
     2641 gctgccttca atctgtagtt taagaagatg ccagggagca tcataaatgg aggctgttgt
     2701 atattaattt agattttttt cactaaaaag aacatgaatg aatttgctcg caggaaggag
     2761 gaaccagttc tctagacccc atgctcactc tacaagacca gctttggtca agctgcccct
     2821 ggggcctgaa gagctgacta tctcctgcct gttccattag aggaccatct tgataatttc
     2881 cccttaaaaa tatcctcaaa aatgtactgg aaggtgggtg gcaggagctt gtacagttca
     2941 gcttccaaca tttcggaaca gatttaaaag ggaatctttt aataaataaa agctacaaaa
     3001 atatttatac tcttgataca atgaaaaagt gtctattaaa tatttggaat tttcttcctt
     3061 gattagtctg ccccaaatcc tgggtatgtt tctcaacctg ggtaagaatt gcatgctttg
     3121 agttcttcat gagtcttata gctctgggca cttatctcta taaagatgat tattttagga
     3181 gatgacagtc atatttcctg aagttggtat tgacacaggg aacatttttg taagcctcac
     3241 aattgtcctt tcttgaggga tgagatgatg aaaatcagcc acagacttaa gatagtgctg
     3301 gaaggcacaa gtggctattg ggccagatgt acccctttct tctagctgaa ataagagaca
     3361 tccttgagtt agaatctagg agcccagcag tttctgaggg cacagctaca tacctttgga
     3421 taaaagctca ccaaaccagt tagttgttcc taattcagga ttagaagaag tccaatgagg
     3481 gaaaaagcgg agttaggtaa gtaagacttt ctgtcccaga taagaaaggg tgggtgtatg
     3541 gcggggaagt gccaagagag ggagtctgcc aagggcccca tggactcaag gaactagatt
     3601 ccttcccaac tgggtagatt tttttttaac tgcccagttt ctccaacccc aatgcctgca
     3661 ccccaacccc cagccattta gaaattgtga ttatattttt aatcatctgt tgctgagaaa
     3721 gcagagaaag gaacagtcag ggagggactc tgggttctct gtgcagtagt tttgttttac
     3781 tgagagactc tcagtgaggt gtacagtttg tagttaacac ttctgggata cagaaaagcc
     3841 tctgttcact cagcctcaga caggcttgct gagaactggg tggatgagca gtggctggga
     3901 gccaaattgc ccctcaggta agctagcttt gtgacttggg tgatgggtga tgtggggagg
     3961 tgcgatatgt gggtgccatt ttgaaattct gcaatgttta agcattacta cacagaatat
     4021 gttgaaaatt gcttactttg ggcaagtgac tttttgagtt tctatggtat ttctttagta
     4081 acttattagc aagctggtat gagataaaaa gttactttac tgaattcttt cccctagtct
     4141 tccttgccat acttgaatgt atcattctta atgacacttt gctgtacttc tgggggttgc
     4201 ctcagcaact ctctcttcac tggcagatgt gccaacatgt atgttgggtc cagaagtctg
     4261 tatgtaccca tcttataaag aagtctccag agctggctga aattccaaat ttcagccaaa
     4321 gctttgggcc aagggaaaga tagtagaaaa tgtgcaaagc agtactgttc atgttagatg
     4381 gatggataca gtgaagaatt aagcctcaca cagaattagc ttgaaacagt actgtcacct
     4441 agggtctggt ctctaggcta gatcaggtta tgggacccta taaattatgt aattagacta
     4501 tacattggtg ggaagttgct aagataaaga cttgctcaaa agactaacag caaaagatgt
     4561 gtgtattgaa atgtatagtt tgctgtagtt caagtggagt cttcagtgca gcaggtagac
     4621 ctagttatac agttatgtat ggaatggaaa gcaaactact gttaaacggt ttttgtctct
     4681 cccctgccac cttctttaga tttcttaatc tcctgtgtgt gtcaggatgg ctagtgatga
     4741 cctgaacatc tataactgac aaaggtctac ttgggggact aaagcagtat ttagcttaaa
     4801 tatgtgaaag aacaaaatta tcaaaagatg ttgattagga ttatttaagg tcatgtgaca
     4861 ttgatctttt cttctacgtc atggttcttg ccacactcct attctgagtt tatttttttg
     4921 gtaagctgta gttgtagccc ataacagttt gacctggcct aggactacat gctggggatg
     4981 ctcatcagga cctccccccc cccccttttt tttttttcaa agaaggatgc ttgagcattg
     5041 ggcacagatg ctgaggtggt ttgactagct gaagttctga ttcgggtgtt ggggcatcat
     5101 attctgtttc tcttgggaac ccagcctgct ctcatagata cctacttcta tcacataccc
     5161 tgagcattgc caaaagaagc cattcagcag ctgctgtttt tctctcagca caaatatatt
     5221 tgctacagaa gaactatctt ttctctaata ctaattcccc gtccagtcct cagaatctga
     5281 ttaactgttc ttccctgctg cactgaatat gttcgagatt ttaaagaggg aatttgaagc
     5341 aataggcaaa cagggcttgg ttgaattggt cttgcatata tcctgtctta agccaatgag
     5401 gtgatgagtc cactgctcat gtgaccctgc acctttgtgg atccttcttg gtttgtgacc
     5461 agtgtacgtt tcttgaggtt gtacaaactt gacaaaagtt aatacttttg tattctctgc
     5521 actgttgcac tcttcaaata gccccctgaa tattaccttg atatacacat ttttgtcttt
     5581 gatgtctaca gtatttttct ttttttttta aatttgaagg ttatctgctg ttggattcaa
     5641 taaatttgtt tacctaa
//
LOCUS       NM_001438237            5532 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 3 (Dcun1d3), transcript variant 2, mRNA.
ACCESSION   NM_001438237 XM_039078621
VERSION     NM_001438237.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5532)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039078621.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.4109.1,
                                           SRR26643299.4203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000001.1  183716343-183716424 c
            83-619              JAXUCZ010000001.1  183681017-183681553 c
            620-5532            JAXUCZ010000001.1  183674364-183679276 c
FEATURES             Location/Qualifiers
     source          1..5532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..5532
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
     exon            1..82
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            83..619
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    102..104
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="upstream in-frame stop codon"
     CDS             189..1103
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; DCN1,
                     defective in cullin neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_001425166.1"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
                     /translation="MGQCVTKCKNPSSTLGSKNGDRDPSSKSHSRRGASHREEQVPPC
                     GKPAGDILVNGTKKAEAATEACQLPTSSGDAGRESKTNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREVEGRGALSSGPEGLCPEEQT"
     misc_feature    189..449
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    678..1016
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    678..1016
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    1041..1100
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            620..5532
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgaggag gaggcggcgg ccgcggtggc agaaaaggcg gcggcggcgg gggtagggag
       61 cctggaaacg caagcgggga tggttggctg gctcctctaa ctgatggcat gttgaagtac
      121 atggaccagt ggcagcgaag ggatctgatc cagagtgggc cactctagaa ggccaggcta
      181 caatcaccat gggccagtgt gtcaccaaat gcaagaatcc ttcatcaacc ttgggcagca
      241 agaatggaga ccgggacccc agcagcaagt cacacagcag gcggggggct agccaccgtg
      301 aggaacaggt gccaccttgt ggcaaaccag ctggggatat tcttgtcaat gggaccaaga
      361 aagcagaggc tgccaccgag gcctgccagc tgccaacttc ttctggagat gcagggaggg
      421 agtccaagac caatgctgag gagtcttcct tgcagaggtt ggaagaactg ttcaggcgct
      481 ataaggatga gcgggaggat gcaattttgg aggaaggcat ggagcgcttt tgcaatgacc
      541 tatgtgttga tcctacggag tttcgagtgc tgctcttggc ctggaagttc caggctgcta
      601 ccatgtgcaa attcaccagg aaggagtttt ttgacggctg taaagcaata agtgcagaca
      661 gcattgatgg gatctgtgca cgtttcccta gcctcttaac agaagccaaa caagaagata
      721 aattcaagga tctctaccgg tttacatttc agtttggcct ggactctgaa gaagggcagc
      781 ggtcactgca tcgtgaaata gccattgccc tgtggaaatt agtatttaca cagaacaatc
      841 ctccagtatt ggaccagtgg ctaaatttcc taacagagaa cccttcggga atcaagggca
      901 tctcccggga cacttggaac atgtttctta acttcactca ggtgattggc cccgacctca
      961 gcaactacag tgaagatgag gcctggccga gtctctttga tacctttgtg gagtgggaaa
     1021 tggagagaag gaaaagagaa gtggaaggga gaggtgcact cagctcaggg cccgagggct
     1081 tgtgtccaga agagcagact tagctgctct gttccaggag cagcactgag gatctgcctg
     1141 ctgccctgca gccaagtgag gaattggacc tttctggaaa ttaccgaaga tccggatatt
     1201 ttctactttc acctttctct gccttgtatt tgaaagggct ctaaaatgct gtatcatgtt
     1261 ttaggcactt tcttcatttt tttttttggg ttattttggt tatttctttt tgggggtggg
     1321 aaatcccccc aaaatatttg aacctggcta catgttgtgt accttttttt gaagccttca
     1381 gatagaataa gcctgccatt tcttgcacaa ctttattaga tttgttttgt ttttgtgggg
     1441 gagggtgtag acccgggttg gggagtggga ctgttaggtt gaattaacat tacaaaatga
     1501 tacagtgcca gatctcagtt ttgcatatta tttttcaggg caggtctgta ctgtgtgtag
     1561 tgctgtttac atggttgaat ttaggttgta ataattattt taaaagattt acacagatat
     1621 gaatatagca gtgttaactg ttagccacat tgcattaatt tccagacagt ttggagctct
     1681 tggagagcca aggccaaggc ccgtcaggag catttgcagt cttgacaccc caccccatcc
     1741 ctttacgcta atttatccaa agccctatct ccctcacttc ctgctcattc cttctctaac
     1801 ctatattgca tttcatgttt aacttatcca tcaacatgct gtacctgtca gtcaagtgag
     1861 cagttttgtt ttgttcgaac acattgtact gaaaaccact taagcattga atgcagagaa
     1921 agcagtgcta cctcagtttt gctggaagta gacttctttg atattttctt tgatgttttt
     1981 gtattttcat gtcataagtg gaaatacttc tttttccccc ttttcatttg ccttggagcc
     2041 aaagtttccg ttgttgtggg tggtgagaaa agtgtgcctg cctgcctgcc tgccagctga
     2101 ccggacagaa agctgtggca tggggctctg ctccagactg cttttcttta gtttttgttg
     2161 agtatcacta gcttacttgt ctggcaagtg cagaagcctg aggctggcct gaactctgcc
     2221 aaacaaatta tccacgtgta ttgaatcatt aaatgtgtgc cctctccctc tttgctgcgc
     2281 ccatgttgtc acttaacccc aggagttatt tattgtcttt tgttagtgtc aggctcacct
     2341 ggggtgacgt gatggctgtt taggtttaca cggccctctg ctctttccct actcccagac
     2401 atgtatatat acatatataa gatatgtata tattttacct tataaaatat atatatacac
     2461 atatatgtat ctatatccct gcgtttgtct gctaaaactg gccatgaaag agggagctgc
     2521 cttcaatctg tagtttaaga agatgccagg gagcatcata aatggaggct gttgtatatt
     2581 aatttagatt tttttcacta aaaagaacat gaatgaattt gctcgcagga aggaggaacc
     2641 agttctctag accccatgct cactctacaa gaccagcttt ggtcaagctg cccctggggc
     2701 ctgaagagct gactatctcc tgcctgttcc attagaggac catcttgata atttcccctt
     2761 aaaaatatcc tcaaaaatgt actggaaggt gggtggcagg agcttgtaca gttcagcttc
     2821 caacatttcg gaacagattt aaaagggaat cttttaataa ataaaagcta caaaaatatt
     2881 tatactcttg atacaatgaa aaagtgtcta ttaaatattt ggaattttct tccttgatta
     2941 gtctgcccca aatcctgggt atgtttctca acctgggtaa gaattgcatg ctttgagttc
     3001 ttcatgagtc ttatagctct gggcacttat ctctataaag atgattattt taggagatga
     3061 cagtcatatt tcctgaagtt ggtattgaca cagggaacat ttttgtaagc ctcacaattg
     3121 tcctttcttg agggatgaga tgatgaaaat cagccacaga cttaagatag tgctggaagg
     3181 cacaagtggc tattgggcca gatgtacccc tttcttctag ctgaaataag agacatcctt
     3241 gagttagaat ctaggagccc agcagtttct gagggcacag ctacatacct ttggataaaa
     3301 gctcaccaaa ccagttagtt gttcctaatt caggattaga agaagtccaa tgagggaaaa
     3361 agcggagtta ggtaagtaag actttctgtc ccagataaga aagggtgggt gtatggcggg
     3421 gaagtgccaa gagagggagt ctgccaaggg ccccatggac tcaaggaact agattccttc
     3481 ccaactgggt agattttttt ttaactgccc agtttctcca accccaatgc ctgcacccca
     3541 acccccagcc atttagaaat tgtgattata tttttaatca tctgttgctg agaaagcaga
     3601 gaaaggaaca gtcagggagg gactctgggt tctctgtgca gtagttttgt tttactgaga
     3661 gactctcagt gaggtgtaca gtttgtagtt aacacttctg ggatacagaa aagcctctgt
     3721 tcactcagcc tcagacaggc ttgctgagaa ctgggtggat gagcagtggc tgggagccaa
     3781 attgcccctc aggtaagcta gctttgtgac ttgggtgatg ggtgatgtgg ggaggtgcga
     3841 tatgtgggtg ccattttgaa attctgcaat gtttaagcat tactacacag aatatgttga
     3901 aaattgctta ctttgggcaa gtgacttttt gagtttctat ggtatttctt tagtaactta
     3961 ttagcaagct ggtatgagat aaaaagttac tttactgaat tctttcccct agtcttcctt
     4021 gccatacttg aatgtatcat tcttaatgac actttgctgt acttctgggg gttgcctcag
     4081 caactctctc ttcactggca gatgtgccaa catgtatgtt gggtccagaa gtctgtatgt
     4141 acccatctta taaagaagtc tccagagctg gctgaaattc caaatttcag ccaaagcttt
     4201 gggccaaggg aaagatagta gaaaatgtgc aaagcagtac tgttcatgtt agatggatgg
     4261 atacagtgaa gaattaagcc tcacacagaa ttagcttgaa acagtactgt cacctagggt
     4321 ctggtctcta ggctagatca ggttatggga ccctataaat tatgtaatta gactatacat
     4381 tggtgggaag ttgctaagat aaagacttgc tcaaaagact aacagcaaaa gatgtgtgta
     4441 ttgaaatgta tagtttgctg tagttcaagt ggagtcttca gtgcagcagg tagacctagt
     4501 tatacagtta tgtatggaat ggaaagcaaa ctactgttaa acggtttttg tctctcccct
     4561 gccaccttct ttagatttct taatctcctg tgtgtgtcag gatggctagt gatgacctga
     4621 acatctataa ctgacaaagg tctacttggg ggactaaagc agtatttagc ttaaatatgt
     4681 gaaagaacaa aattatcaaa agatgttgat taggattatt taaggtcatg tgacattgat
     4741 cttttcttct acgtcatggt tcttgccaca ctcctattct gagtttattt ttttggtaag
     4801 ctgtagttgt agcccataac agtttgacct ggcctaggac tacatgctgg ggatgctcat
     4861 caggacctcc cccccccccc tttttttttt ttcaaagaag gatgcttgag cattgggcac
     4921 agatgctgag gtggtttgac tagctgaagt tctgattcgg gtgttggggc atcatattct
     4981 gtttctcttg ggaacccagc ctgctctcat agatacctac ttctatcaca taccctgagc
     5041 attgccaaaa gaagccattc agcagctgct gtttttctct cagcacaaat atatttgcta
     5101 cagaagaact atcttttctc taatactaat tccccgtcca gtcctcagaa tctgattaac
     5161 tgttcttccc tgctgcactg aatatgttcg agattttaaa gagggaattt gaagcaatag
     5221 gcaaacaggg cttggttgaa ttggtcttgc atatatcctg tcttaagcca atgaggtgat
     5281 gagtccactg ctcatgtgac cctgcacctt tgtggatcct tcttggtttg tgaccagtgt
     5341 acgtttcttg aggttgtaca aacttgacaa aagttaatac ttttgtattc tctgcactgt
     5401 tgcactcttc aaatagcccc ctgaatatta ccttgatata cacatttttg tctttgatgt
     5461 ctacagtatt tttctttttt ttttaaattt gaaggttatc tgctgttgga ttcaataaat
     5521 ttgtttacct aa
//
LOCUS       NM_001438187            6560 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 2 (Man2a2),
            transcript variant 2, mRNA.
ACCESSION   NM_001438187 XM_063262641
VERSION     NM_001438187.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6560)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063262641.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.3592.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               JAXUCZ010000001.1  143736484-143736867 c
            385-582             JAXUCZ010000001.1  143736112-143736309 c
            583-733             JAXUCZ010000001.1  143734935-143735085 c
            734-991             JAXUCZ010000001.1  143733704-143733961 c
            992-1136            JAXUCZ010000001.1  143733490-143733634 c
            1137-1308           JAXUCZ010000001.1  143733200-143733371 c
            1309-1436           JAXUCZ010000001.1  143732663-143732790 c
            1437-1610           JAXUCZ010000001.1  143732254-143732427 c
            1611-1797           JAXUCZ010000001.1  143731769-143731955 c
            1798-1975           JAXUCZ010000001.1  143728703-143728880 c
            1976-2178           JAXUCZ010000001.1  143728263-143728465 c
            2179-2361           JAXUCZ010000001.1  143727948-143728130 c
            2362-2476           JAXUCZ010000001.1  143727685-143727799 c
            2477-2544           JAXUCZ010000001.1  143727397-143727464 c
            2545-2710           JAXUCZ010000001.1  143727107-143727272 c
            2711-2947           JAXUCZ010000001.1  143725781-143726017 c
            2948-3070           JAXUCZ010000001.1  143724508-143724630 c
            3071-3185           JAXUCZ010000001.1  143724133-143724247 c
            3186-3319           JAXUCZ010000001.1  143723765-143723898 c
            3320-3461           JAXUCZ010000001.1  143722979-143723120 c
            3462-3598           JAXUCZ010000001.1  143721013-143721149 c
            3599-3793           JAXUCZ010000001.1  143718013-143718207 c
            3794-3901           JAXUCZ010000001.1  143717730-143717837 c
            3902-6560           JAXUCZ010000001.1  143713966-143716624 c
FEATURES             Location/Qualifiers
     source          1..6560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6560
                     /gene="Man2a2"
                     /note="mannosidase, alpha, class 2A, member 2"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
     exon            1..384
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..582
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    560..562
                     /gene="Man2a2"
                     /note="upstream in-frame stop codon"
     exon            583..733
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..4054
                     /gene="Man2a2"
                     /EC_number="3.2.1.114"
                     /note="isoform 2 is encoded by transcript variant 2;
                     alpha-mannosidase 2x; mannosidase 2, alpha 2"
                     /codon_start=1
                     /product="alpha-mannosidase 2x isoform 2"
                     /protein_id="NP_001425116.1"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPEDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLETHLRGAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNG
                     VKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVRRVDEEQEQQVDMK
                     LFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEVAAYYEHFHQVIR
                     LYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNHFRLLLERRTLMSPEVQQERSTSYPSLLSHMTSMYLNTPPLVLPVA
                     KRESTSPTLHSFHPLASPLPCDFHLLNLRMLPAEDTLPAADAALILHRKGFDCGLEAK
                     NLGFNCTTSQGKLALGSLFHGLDVLFLQPTSLTLLYPLASPSNSTDISLEPMEISTFR
                     LRLG"
     misc_feature    1019..4048
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     misc_feature    1019..4048
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     exon            734..991
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1136
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1308
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1436
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1610
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1797
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1975
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2178
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2361
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2476
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2544
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2710
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2947
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3070
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3185
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3319
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3461
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3598
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3793
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3901
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..6560
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtggacc ccagcgccga cccagcggga ggagaccgag ctgggtgcca gggggcgctg
       61 cggaacccgg cggggggcga ggcagcggcg gggcccggca ctaggggacg ctgcacgcag
      121 tccccccgcg cccctcctcc tgcccggcgc gccgctcgac cccgcggagg cgggagcgcg
      181 ggagcacaga cgcggggcga gcgcagggag cgcgcagcgg tcctgtcccc cgcgggagcg
      241 cggctgcagg gccgagccgg ggcggtgggt gggcaggcgt ctgtcttagc ctgcgcatct
      301 gccagcgcgc tggcggaggt ccccggggat gcgagcagtg gcggcttggc gggccgggtc
      361 cggagcgccg cggaggccgg ccgcctccgc cctctgtggc ccggacccaa tctccaggga
      421 ctaaaaatat tgcccggagg ctcctgagcg gaatcagatc gcgttaagta ggacgcaggc
      481 tgaggtgaca gagcttttca gcaccagggc cggaagagca gactccagaa cgcggtcccg
      541 cccacgcgcg ttcaggagct agcgtcctcc ctcctccagc aggagtgtgc ctggtgtcag
      601 tatgaagctg aaaaagcagg tgacagtgtg cggggctgct atcttctgtg tggccgtctt
      661 ttccctgtac ctaatgctgg accgagtgca gcatgatcct gccagacacc agaatggtgg
      721 gaacttcccc aggagccaaa tttctgtgct acagaaccgg atcgaacagc tggaacagct
      781 gctggaagaa aaccatgaga tcataagcca tatcaaggac tctgtgctgg aactgacagc
      841 caatgcggag ggcccaccag ccctgctgcc ctaccacaca gccaacggct cctgggctgt
      901 gctccccgag ccccggccca gcttcttctc tgtatcccct gaggactgcc agtttgcttt
      961 ggggggccgg ggtcagaagc cagagctaca gatgttaact gtgtctgagg atttgccgtt
     1021 tgacaatgtg gagggcggcg tgtggaggca aggcttcgac atctcctaca gcccaaatga
     1081 ctgggatgct gaagacctgc aggtgtttgt ggtgcctcac tcccacaatg atccaggctg
     1141 gatcaagact tttgacaagt actacacgga acaaacccaa cacatcctca acagcatggt
     1201 gtccaagctg caggaagatc cccgacggcg ctttctctgg gcagaagtct ccttcttcgc
     1261 caagtggtgg gacaacatca gtgcccagaa aagggcagca gttcgaaggc tggtgggaaa
     1321 tgggcagctg gaaattgcaa cgggtggatg ggtgatgcca gatgaggcca actcccatta
     1381 ctttgccctg gtcgaccagc tcatcgaggg acaccagtgg ctggagagaa acctgggtgc
     1441 aactcctcgc tcgggctggg cagtggaccc ctttggacac agctccacca tgccttacct
     1501 gctgcgccgt gccaacctga ccagcatgct aattcagagg gtgcattacg ccatcaagaa
     1561 gcactttgcg gccactcaca gcctggagtt catgtggagg cagacatggg attcagactc
     1621 cagcacagac atcttctgcc acatgatgcc cttctacagc tacgacgtcc cacacacctg
     1681 tggccctgat cccaagatct gctgccagtt tgatttcaaa cgtctgccgg gtgggagaat
     1741 caattgtcct tggaaggtgc cgccgcgggc tatcacagag gccaacgtgg cagacagggc
     1801 agccctgctc ctggaccagt accggaagaa gtcccggctg tttcgaagca gtgtcctcct
     1861 tgtgccgctg ggtgatgact tccgatatga caagccccag gaatgggatg cccagttctt
     1921 caactatcaa cggctctttg acttcctcaa cagcaagccg gagttccacg tacaggcaca
     1981 gtttgggacc ctctctgagt attttgatgc cctgtataag aggacaggag tggagcctgg
     2041 tgcccggcct ccagggtttc ctgtgctgag tggggacttc ttctcctatg ctgaccggga
     2101 ggaccactac tggacaggct attacacttc ccggcctttc tataagagct tggaccgcgt
     2161 gctagaaact caccttcgtg gggcagaggt tctatacagc ctggctttgg cgcatgcccg
     2221 ccgttctgga ctgactggcc agtatccgct gtctgattac gctgtcctga cggaagctcg
     2281 tcgtacactg ggcctcttcc agcaccacga tgccatcacc ggaactgcca aggaggcagt
     2341 tgtagtagac tatggggtca ggttgctgcg ttccctggtc agcctaaagc aggtcatcat
     2401 caatgctgcc cactacctgg tgctggggga caaggagacc tacagctttg accctagggc
     2461 acccttcctc caaatggatg acagtcgagt aagtcacgat gccctgcctg agcgcacggt
     2521 gatccgtctg gactcctcac ccaggtttgt ggtggtcttt aacccactgg aacaggagcg
     2581 gctcagtgtg gtgtccctgc tggtcaactc accccgagtg cgagtgcttt cagaggaggg
     2641 tcagcccttg tctgtgcaga tcagtgtgca gtggagctcc gccaccaaca tggtccccga
     2701 tgtctaccag gtgtcagtgc ctgtccgcct gccagccctg ggcctgggtg tgctgcagct
     2761 gcagccagat ctcgatggac cctacacact gcagtcttcg gtgcatgtct acctgaacgg
     2821 cgtgaaactg tctgtcagca ggcaaacaac attccctctc cgtgttgtgg actcgggcac
     2881 cagtgacttc gccatcagca atcgatacat gcaggtctgg ttctccggcc ttactgggct
     2941 tctcaagagc gtccgacgtg tggacgaaga gcaggaacag caggtggaca tgaagctctt
     3001 cgtctatgga acccgcacat ccaaggataa gagtggtgcc tacctcttcc tgcctgataa
     3061 cgaggctaag ccctatgtcc ctaagaaacc tcctgtgctg cgcgtcaccg aaggcccttt
     3121 cttctcagag gtggctgcgt attatgagca ctttcaccaa gtgattcgac tttacaacct
     3181 gccaggggta gaggggctgt ctctggacgt gtcgttccag gtggacatca gggactacgt
     3241 gaacaaggag ctagccctgc gcatccacac agacatcgac agccagggca ctttcttcac
     3301 agacctcaat ggctttcagg tacagccccg gaagtatctg aagaagttgc ccctgcaggc
     3361 taatttctac cctatgccag tcatggccta catccaggat tcccagaggc gcctcacgct
     3421 gcacactgct caggctctgg gtgtctccag cctcggcaat ggccagctgg aggtgatctt
     3481 ggaccgaagg ctaatgcagg atgacaaccg gggactaggc caagggctca aagacaacaa
     3541 gatcacctgc aaccatttcc gcctcctgtt agaacgtcga accctgatga gccctgaggt
     3601 ccaacaggag cgctctacaa gctacccgtc cctcctcagc cacatgactt ccatgtacct
     3661 caacacacct cctctggtct taccggtggc caagagggag agcaccagcc ccactctgca
     3721 ctctttccac cctctggctt ctccgttgcc ctgcgatttc catctgctca atctgcgcat
     3781 gctccccgcc gaggacacct tgcccgcggc tgatgctgct ctcatcctac accgcaaggg
     3841 ttttgactgt ggccttgaag ccaagaacct gggcttcaac tgtaccacaa gccaaggcaa
     3901 gctggccctg gggagcctct tccatggcct ggatgtgcta ttcctgcagc ccacctcttt
     3961 gactttgcta taccctctgg cctcgccctc caacagcact gacatctctc tggagcccat
     4021 ggagatcagc accttccgcc tgcgcttggg ttaggttagg gcttcttgtg gcctgaagac
     4081 gaagttcatc cacaaagact gcctcctaac accaagaccg agttggacca gccacactga
     4141 gtatcacatt ctgcctcaga actgacagac catgctctgc ccttacgttg tctattgctg
     4201 cttctgtgtt tgggccagcc cttacatcag cagacggcag atacagtggg acagggagag
     4261 gaggcccttc ccttgggttg taagtagctg cccagctggg cacggcttag gttccatcct
     4321 tttcccacaa tgggatctag gaagagcggg gacaaacaga agaggtcagg gaggctgagg
     4381 ggaacaacct cgcaccaggt gactggagtt atgaccgtgc tctgtggggt gataggggcc
     4441 ccacagtgct ggtatgaggg tacaggtgca gggtgattct gggagatgag gggtaggtac
     4501 ctgttattag tggagtaaag gcgtggagga gtccctgttt ctcctgagag cctaaaggct
     4561 ttgttgctct ctgttctggc tctgctctaa gtgctgctgg gcctttatgc cctggctagg
     4621 ggctgctggg tggcaggaag ggcttgctgg acactccagg ccgaggccac agagcacttg
     4681 aggtattcgt gccagttttc agctgctcat ttggtgttga tttgtggcag ggtagggagt
     4741 gtctccacct gacctgcttc tttatctcac acaccagtct ccctacaagt tcccattgcc
     4801 gggaccctgg cagtgttcct ttccctagaa gggaaacgga gcttccaaga cccctatgct
     4861 tgggcatctt gggaaagcaa tcccatgctg gatcccccgg caggttcacc gtgttccatc
     4921 tgcccggtgt gtggacaagg aagacagaga taaaattagg aggcatgtgc ttcgatgagc
     4981 ctccggtttt gcttcactcg atagagaatc tgtctataaa caataagatt tggtaaaagc
     5041 gaagtctcat ccttatgaaa acgtagtaag ccaagttaga aagaagcgcc atgatctaga
     5101 gaaaggtctc tgtcaccagt tactaaggca cagcgcagcc attcccctga gagtcagaag
     5161 ctggccggtg gcatgctggt acttaagggt gtcctggtgt cactaaccca tactccagat
     5221 ggagacaaga attataattg ccactgtttt aaaaccataa gctacctaag aaacctgcgt
     5281 cagccaaaga cccagcaagg ctttctatga gttgcccagt gaagactggt tctcccaaaa
     5341 tcagcccata aaaacaatgt cattcccacg agattggata ctttttggaa ttctgcagat
     5401 ttggcgttat ctggaggatg acaggctgag gatgtgaagt agttctgaat ggcagtggtg
     5461 atgtgtggcc ggtgacactg aggcggccac aggcaggtgt cttatcagag ttctcaaagg
     5521 acttggactc ttctgccagt gtgaattcag ctgccatgag aggtcaggtc agacagacct
     5581 aggcacatag aaatttagta tatgatttca agtgcagggg agggagatga agtatttaat
     5641 agtgctttga gacaactagc tatctgtgag acttctatct cggtttcaaa aacaaaataa
     5701 aaccaaaaaa ccctagggct agaggggaaa aaaaaaaaca aaacaacaaa atcatcatca
     5761 tcatcaccat cgtcatcatc atcgtcatca tcatcatcat catcatcagc ccactatgta
     5821 cctctgactg tgctggaact ctctatgtaa accacgctgg cctggaaatc accaagatac
     5881 tcacccgcct ctgcctccta aatgctggga ctaaaggctt gtacacctgg aaagaaaaaa
     5941 tatttttata cccgttgtag gaaaaaggct tttctagaca taacgtgaaa ccgaatacat
     6001 aatgggggaa agacatacac acacacacac acacaaagct tgagagcatg ctataggaaa
     6061 caggttaaat caatacaggt gcgtgggtgg gagagcatgt gtgtgagtac cttcattgca
     6121 ggagaaagtg ttttgacttc tcagagaacg gcaccagggt ctgtccagca gtcacccaaa
     6181 gattcagtag tgacagggtt gagttctttt tttttttttt tccggagctg gggactgaac
     6241 ctctactgct gagctaaatc cccagccccc agggttgagt tctcttgcag gtcctccaga
     6301 gtttttgctg ccaggctcag accacatggc ttcctattca tgtcttggtg acagaaataa
     6361 ggtgaagctt agagagcact tatcatagag tgggggttgt ggataagctc ctcagtgtga
     6421 gcataaacat ggtagaaagc ctacggaaac actcggacag caagtgttgt ttgctggtct
     6481 gtggtttgta atcaaatgat aggggacact gtgaacccct aggaactttg cagaataaag
     6541 gatattcttt ggaggtcaga
//
LOCUS       NM_001438179            5266 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 5 (Smc5),
            transcript variant 2, mRNA.
ACCESSION   NM_001438179 XM_006231184
VERSION     NM_001438179.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5266)
  AUTHORS   Raschle,M., Smeenk,G., Hansen,R.K., Temu,T., Oka,Y., Hein,M.Y.,
            Nagaraj,N., Long,D.T., Walter,J.C., Hofmann,K., Storchova,Z.,
            Cox,J., Bekker-Jensen,S., Mailand,N. and Mann,M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 5266)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   3  (bases 1 to 5266)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   4  (bases 1 to 5266)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   5  (bases 1 to 5266)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   6  (bases 1 to 5266)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (bases 1 to 5266)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (bases 1 to 5266)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006231184.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.5990.1,
                                           SRR26643429.5244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000001.1  230265372-230265641 c
            271-412             JAXUCZ010000001.1  230260591-230260732 c
            413-465             JAXUCZ010000001.1  230258553-230258605 c
            466-628             JAXUCZ010000001.1  230257157-230257319 c
            629-763             JAXUCZ010000001.1  230254913-230255047 c
            764-904             JAXUCZ010000001.1  230253016-230253156 c
            905-1066            JAXUCZ010000001.1  230251195-230251356 c
            1067-1138           JAXUCZ010000001.1  230248476-230248547 c
            1139-1394           JAXUCZ010000001.1  230242698-230242953 c
            1395-1549           JAXUCZ010000001.1  230241244-230241398 c
            1550-1663           JAXUCZ010000001.1  230230611-230230724 c
            1664-1758           JAXUCZ010000001.1  230227615-230227709 c
            1759-1891           JAXUCZ010000001.1  230225850-230225982 c
            1892-2065           JAXUCZ010000001.1  230223379-230223552 c
            2066-2235           JAXUCZ010000001.1  230223126-230223295 c
            2236-2359           JAXUCZ010000001.1  230220574-230220697 c
            2360-2482           JAXUCZ010000001.1  230220012-230220134 c
            2483-2608           JAXUCZ010000001.1  230211473-230211598 c
            2609-2704           JAXUCZ010000001.1  230208051-230208146 c
            2705-2809           JAXUCZ010000001.1  230207469-230207573 c
            2810-2929           JAXUCZ010000001.1  230207167-230207286 c
            2930-3109           JAXUCZ010000001.1  230199842-230200021 c
            3110-3205           JAXUCZ010000001.1  230199669-230199764 c
            3206-5266           JAXUCZ010000001.1  230196647-230198707 c
FEATURES             Location/Qualifiers
     source          1..5266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..5266
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
     exon            1..270
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3349
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="isoform 2 is encoded by transcript variant 2; SMC5
                     structural maintenance of chromosomes 5-like 1; structural
                     maintenance of chromosomes protein 5"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5
                     isoform 2"
                     /protein_id="NP_001425108.1"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
                     /translation="MATPSGKAAAPNPQASKRSLPRDASSEFPSKRKNSNPTSTLPRP
                     SGLFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKI
                     VEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNF
                     REKEKQLETSCKEKTEYLDKMIQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQRRTLEVRIKEKATDIKEA
                     SQKCKQRQDLIERKDRHIKELQQALTVKQNEEQDRQKRISNTRKMIEDLQNELRTAEN
                     CENLQPQIDAITNDLRRVQEEKALCEGEIIDKQREKEMLEKQKRSVSDHITRFDNLMN
                     QKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSND
                     LRAFVFESQEDMEIFLREVRDNKKLRVNAVIAPKISYADKAPSRSLNELKQYGFFSYL
                     RELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTS
                     FYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEINRKLEAVDSGLVALRDTNRH
                     LELKDNELRLKKKELLERKTKKRQLEQKISSKLASIRLMEQDTCNLEEEERKASTKIK
                     EINVQKAKLVTELTGLVKICTSLHIQKVDLILQNTTVISEKNKLEADYMASSSQLRVT
                     EQQFIELDDNRQRLLQKCKELMKRARQVCNLSADQAVPQEFQTAFQDLPNTLDEIDAL
                     LTEERSRASCFTGLNPSVVEEYTKREIEIQQLTEELKGKKVELDEYRENISQVKERWL
                     NPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELT
                     PHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKEN
                     TSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPSQ"
     misc_feature    236..>673
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    236..>673
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    242..3196
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    242..3196
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    323..346
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213244"
     misc_feature    323..346
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213244"
     misc_feature    617..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213244"
     misc_feature    617..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213244"
     misc_feature    <2963..3271
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <2963..3271
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    3011..3040
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213244"
     misc_feature    3011..3040
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213244"
     misc_feature    3083..3100
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213244"
     misc_feature    3083..3100
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213244"
     misc_feature    3107..3118
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213244"
     misc_feature    3107..3118
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213244"
     misc_feature    3188..3208
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213244"
     misc_feature    3188..3208
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213244"
     exon            271..412
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..465
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..763
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..904
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1066
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1138
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1394
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1549
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1663
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1758
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1891
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2065
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2235
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2359
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2482
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2704
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2809
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2929
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3109
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3205
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..5266
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttagcgcg ggagccgggc gcggaggctc ctgggctgcg gctcgccggg aacggaagcc
       61 gctgcgggac gcggaggaag ccaggatggc gactccgagt gggaaagctg ctgcccctaa
      121 cccccaggct tccaagaggt ctctcccgag agatgcttcc tccgagttcc cgagcaagag
      181 aaagaactcg aacccgacgt cgacgctgcc gcggccgtcc ggactcttcg tggagggctc
      241 aatcgtccgc atcgccatgg agaacttctt aacatatgac atctgtgaag tgtctcctgg
      301 gccccatctg aatatgatta ttggagccaa tggaacaggg aagtcaagca tagtgtgtgc
      361 catttgcctt ggcctagcag gcaagcctgc tttcatgggg cgtgcagata aggttgggtt
      421 tttcgtgaag agaggatgtt ccaaaggttt ggttgaaatt gaactgttca ggacttctgg
      481 aaatcttata atcacccgtg aaattgatgt gataaaaaat cagtcctttt ggttcatcaa
      541 caaaaaacct gtaacccaga agatagtgga agagcaagtc gcggccttga acatccaagt
      601 gggcaacctc tgccagttct tgcctcagga caaagttgga gaatttgcta aactcagtaa
      661 aattgaactc ctcgaagcta ctgagaagtc aattggtcct ccagagatgc acagatacca
      721 ctgtgaactc aagaacttca gggagaagga gaagcagcta gagacttctt gcaaagagaa
      781 aactgaatac ctagacaaaa tgattcagag aaatgaaagg tacaaacaag atgtagaaag
      841 attctatgaa cgaaaacgac atttagattt aattgagatg cttgaggcaa aaagaccatg
      901 ggtggaatat gagaatgtgc gtcaggaata tgaaggtgtg aaactagtcc gtgaccgagt
      961 gaaggaagag gtcagaaaac tcaaagaagg gcagattcct atgacacggc ggattgagga
     1021 aattgaaagg cagcgtcgca ctttggaagt tcgaatcaaa gaaaaggcaa ctgatattaa
     1081 ggaagcgtct cagaaatgca aacaaaggca ggacttgatt gagcggaagg acagacatat
     1141 taaggaactt cagcaagcat taacagtcaa gcagaatgag gagcaggacc ggcagaagag
     1201 aataagtaac acccgcaaga tgatagaaga cttgcagaat gagctcagga ctgcagaaaa
     1261 ctgcgagaac cttcagcctc agattgatgc catcacaaat gatctaaggc gtgttcaaga
     1321 ggagaaggca ttatgtgaag gcgagatcat tgataaacag agagaaaagg aaatgctgga
     1381 gaagcagaaa cggagtgtga gtgatcatat cacacgtttt gacaatctta tgaatcagaa
     1441 ggaagataag ctgagacaga ggtaccggga tacgtacgat gcagtcttgt ggctgagaaa
     1501 taacagagac aggtttaaac aaagagtctg tgagcccata atgctcacga ttaatatgaa
     1561 agataataaa aatgcaaaat atgttgaaaa tcatatttca tcaaatgact taagagcctt
     1621 tgtgtttgaa agtcaagaag atatggagat tttcctcaga gaggttcgtg acaataagaa
     1681 gttgagagta aatgctgtta ttgctcccaa gatttcatat gcagacaaag caccttcacg
     1741 atctctgaat gagttaaaac agtatggctt tttttcatac cttcgagagt tatttgatgc
     1801 acccgatcct gtgatgagtt acctttgctg ccaatatcat attcatgaag ttcctgtggg
     1861 aactgaaagg acccgagaaa gaattgaacg ggtaatacaa gaaactcgat taaaacagat
     1921 ttatacagca gaagaaaagt atgtgttaaa aacttctttc tattccaata aagttatctc
     1981 tagtaataca tctctgaaag tagcccagtt cctcactgtc actgtggacc tagagcaaag
     2041 gagacacttg gaagaacagc taaaggaaat taatagaaag ctggaagcag tggactcagg
     2101 attggtagcc ttgcgggata caaacaggca tctcgagctc aaagacaatg agctaaggct
     2161 gaagaagaag gagcttcttg aaagaaaaac caagaaaaga caactggaac agaaaattag
     2221 ctccaagctg gcaagtataa ggctgatgga acaggatact tgcaatctgg aagaggaaga
     2281 acgaaaagca agtaccaaaa taaaagaaat aaatgttcaa aaagcaaaac ttgttactga
     2341 attaacgggc cttgtaaaga tatgcacttc tttgcatatt caaaaagttg atttgattct
     2401 tcaaaatact acagtgatct ctgagaagaa caagttagaa gcagattaca tggcgtcctc
     2461 ctcacagctg cgtgtcacag aacaacagtt tattgaattg gatgacaata ggcagagatt
     2521 gttacagaag tgcaaggaac ttatgaagag agctaggcaa gtatgtaacc tgagtgcaga
     2581 ccaagccgtt ccccaagaat ttcagacagc ttttcaagat ctcccaaaca cattggatga
     2641 aatcgatgca ttattaactg aagaaagatc aagagcgtcc tgcttcacag gactgaatcc
     2701 ttcggtggtt gaggagtaca caaaaagaga aatagaaata cagcagttaa ctgaagaact
     2761 aaaggggaag aaagttgaat tagatgaata cagggaaaac atttcgcagg tgaaagaaag
     2821 gtggctgaac cccttaaaag agctagtaga gaaaatcaat gagaagttca gcaacttttt
     2881 tagttccatg cagtgtgctg gtgaagttga tcttcataca gaaaatgagg aagattatga
     2941 taaatatgga atccggatta gagtaaaatt tcgcagtagt actcagctgc atgaattaac
     3001 tcctcatcat caaagtggcg gtgaaagaag tgtttctacc atgctgtact tgatggcact
     3061 tcaggagctt aacagatgtc cattcagagt ggttgatgaa attaatcagg gtatggaccc
     3121 aattaatgaa cggagggtgt ttgaaatggt tgtgaacacc gcctgtaaag agaacacatc
     3181 gcagtacttc ttcatcacac cgaagcttct acagaatctg ccttattctg aaaagatgac
     3241 ggtattgttt gtctacaatg gtcctcatat gctggaacca aaccgatgga atttaaaggc
     3301 ttttcaaagg cggcggcgaa ggatcacatt tactcaacct tctcagtgaa aggaaaggga
     3361 ggggcctgcc gaggttttca tttaactgtt tatacctgtc gctcaagtga ataaaagtta
     3421 gcagatttat tgaaagagaa agattggtta tttttggaag cctgctttta aaaacaaata
     3481 ggttaatgaa gcggagacca tagtgactct ggaccatttc tagtgaaaac taagtcttca
     3541 gttttggtgg accttgtctc attagtcctc tgtgagcatt gttgtgtgaa gctttgtgct
     3601 gcctcaggtg tggtggcaca catctagtcc agcatttagg agacggaggc agaaagatca
     3661 tgagtttgag tggtttcatg tgtcttaaca gaaaaagcta tttccggttg caaatcagag
     3721 gtacggcaga atggggtttc attcacagag cgtttacaaa caatagccgc cctgagtgct
     3781 gattgcagaa catcctgact cttagtgctt aaaggtaact cagaattaga aatcccattt
     3841 gccttcagta ttgtatttag tttttaaaaa ctagtatgag aatgtctgct tagtagatag
     3901 tgatttatgg cagatctgtt catttctttg tgtttagaag aagggttccc ttattttcat
     3961 agaaaatatg ttatcgtaga aaattgatgc tataatttta ttgttatttc aaagaattgg
     4021 gaagacatat acacgtgagg cttcaaaatg acaggaggac tttgagaggt cacaaggtaa
     4081 agatgataca gaatgtggcc caaacattgg cagagtgaaa tcaggtgaca ggagttaaag
     4141 tataattgtt gtgtgtgttt gtcgggggtg ggttctttgt ttgtttgttt aatttaaagt
     4201 caaatgtatt ttacatctta aatttctaca aaggcatttt tataatttta gtaagatttt
     4261 tcttaagatt tcatatatga gattttacaa tttgtatttg aaatttctca gtgctatgta
     4321 aagagtgaag gcaaagaatt gattggtttc aaatcataat atttttagaa tttgtatgtc
     4381 cttccttcta cccagtattt tagaaaactc tcatctaaat tgttttcttc cagcttgaaa
     4441 atattaattg aaaaccattt atttttctct gagaatgcta attaacaatg ccaaacaaat
     4501 tctgtttgtt tgtttttttt ttaaacaaat cttgaaagaa agtagaaatg tctttgaata
     4561 gtggactgaa ctgtatcctt gctggtactg acaaaattat ttttgtgact agctagcctg
     4621 aataaagttt gggctttgta tattattgta atagccaatg agatttgcat tcttattagg
     4681 tcaaaaaata gtgaaacatg agtttatgtc tgctcactta gacattttct cttttagaag
     4741 ttgtatttct ttttaacact tgtaaaagaa cccttccctc ttaaactaca tctcatacat
     4801 gtagtataaa gatattttta ataacatttt tatcagcatg aacaagtcaa aaaattaaaa
     4861 actaggtagg atagtagtga agggtgtttc taaacatttg tgtcgttgct tggatttctg
     4921 acataattaa tatcttcact gatatatgct taatatagtt tggttttatc atgtcaatgt
     4981 gaaacaaaaa caaaccgtac ttaaaactca acatcagcaa tcccatttca gtttacatat
     5041 gtcaaaaatg attctatatc atgcttataa actttcagag agcaaaatta atgttcgttt
     5101 tatattgact ttgggctggg aaggataaat tatgtatcat ttattatatt aaaaatagtc
     5161 atactataat gtcattttct gcaactgttg atttttaaga ttatattata attgtaaaaa
     5221 ttccaagtaa aagcttgatt tgataaataa aatatttaaa acctga
//
LOCUS       NM_001438190            3370 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus fibronectin type III and SPRY domain containing 2
            (Fsd2), transcript variant 2, mRNA.
ACCESSION   NM_001438190
VERSION     NM_001438190.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1928.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000001.1  144931599-144931704 c
            107-333             JAXUCZ010000001.1  144928985-144929211 c
            334-399             JAXUCZ010000001.1  144928822-144928887 c
            400-1072            JAXUCZ010000001.1  144925538-144926210 c
            1073-1168           JAXUCZ010000001.1  144925066-144925161 c
            1169-1399           JAXUCZ010000001.1  144920011-144920241 c
            1400-1422           JAXUCZ010000001.1  144918936-144918958 c
            1423-1544           JAXUCZ010000001.1  144917084-144917205 c
            1545-1700           JAXUCZ010000001.1  144915160-144915315 c
            1701-1835           JAXUCZ010000001.1  144912887-144913021 c
            1836-1986           JAXUCZ010000001.1  144912038-144912188 c
            1987-2120           JAXUCZ010000001.1  144908442-144908575 c
            2121-2256           JAXUCZ010000001.1  144906298-144906433 c
            2257-2433           JAXUCZ010000001.1  144901612-144901788 c
            2434-3370           JAXUCZ010000001.1  144898501-144899437 c
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3370
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="fibronectin type III and SPRY domain containing 2"
                     /db_xref="GeneID:308779"
                     /db_xref="RGD:1305167"
     exon            1..106
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            107..333
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            334..399
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1072
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    416..418
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="upstream in-frame stop codon"
     CDS             446..2686
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /codon_start=1
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2"
                     /protein_id="NP_001425119.1"
                     /db_xref="GeneID:308779"
                     /db_xref="RGD:1305167"
                     /translation="MEEEAGEEPGLGRSTAPRDFHFYHMDLYDSEDRLQLFPGESSRT
                     RREVTQAELTNEPRGAGDSKNLQKEVDALVHLYGLEDEHELGGEFVDEHRLGTLGYPY
                     GMRRRDPGREQRDWGLSGEAAEAEDLCYGVQGPPDQCQDLREAYRYTHGRASEEYECY
                     VIPEEEDEEEPADVFCVTCKTPVRTVEKDFDIHKEHEVTPINKALEHAKDEIHKNMCK
                     LEQQIIEMENFASHLEEVFITVEENFGRQEQNFECHYNEILETLAQKYEEKIQALGEK
                     KKEKLEALYGQLVSCGENLDACRELMETIEEMCHEEKVDFLKDAVAMTDRLGKFLKTK
                     TDVELSAKPEFEDQTLDFSDVEQLMDSINTVPAPSAPVINPQAPNSATGSSVRVCWSL
                     YSDDTVESYQLSYRPVQDSSPGKDQAEFTMTVKETYCSVKNLEPNTQYEFWVIAQNRT
                     GPSPSSEHVVYMTAPSPPSIKTEAIRSCEEAVLICWESGNLNPVDSYTVELIQAETPE
                     ASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVGGTSARSKPATVHTTGSYFQLNK
                     DTCHPWLTISEDGFTVVRSEKKRSFRRELPPSKAQFSRCVAVMGNLIPVRGRHYWEVE
                     VDEHLDYTVGVACEDVPKQEDLGANRLSWCMRHTFASTRHRYEFLHNGTTPDIRITVA
                     PKKIGVLLDYEDSKLSFFNVDIAQHLYTFSCPLHQFVHPCFSLEKSGGLKICNGISAP
                     KHVTFF"
     misc_feature    1052..>1366
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    1052..>1366
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    1547..1804
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1547..1804
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    order(1547..1549,1751..1753,1796..1798)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1547..1549,1751..1753,1796..1798)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    <1550..>2119
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    <1550..>2119
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    order(1799..1804,1808..1813)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1799..1804,1808..1813)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    2126..2656
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     misc_feature    2126..2656
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     exon            1073..1168
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1399
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1422
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1544
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1700
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1835
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1986
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2120
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2256
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2433
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3370
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggtcacc gggaagggga gctgaccaga cagaaatcca atttttccag cagaaaccta
       61 ggaccgtgga gttaaaggac acatttatgg acctttaaat gagcaggaac agtcaatgcg
      121 cagacgaatg agtggacggc tatagcccga cacacagaga gatcaacagc agggctggtg
      181 aggaacccca ggtttccccc agacggtgac tgagaatgca gacttcctga tcattccatg
      241 ttgcccaaag ccaggagtgc cagaacttcc gaacctctgg atgaccttgg ggcttgcctc
      301 atgctggaag ctgaggcagc agccggggcc cagactatcg accctcttct tcattcttcc
      361 cctcgccccc ccaaggtgcc gaatcagagc ttacagcagg tctcagaata cccactgact
      421 gactaggaag ggctgttctg tgtcaatgga ggaggaagca ggggaggagc cggggctggg
      481 gagatcaaca gcccccagag acttccactt ttatcacatg gacctgtatg actctgaaga
      541 tagactgcag ctcttcccag gagaaagcag cagaacccgg agggaagtaa cccaggctga
      601 actgaccaat gagccaagag gggcagggga cagtaagaat ctccagaagg aagtggacgc
      661 gcttgtccat ttatacgggc ttgaagatga acatgagtta gggggtgaat ttgtggatga
      721 acacagattg gggactctgg ggtatccgta cgggatgagg aggagggatc caggcaggga
      781 gcagagagac tgggggctta gtggtgaggc agctgaggcc gaggacctgt gctacggagt
      841 tcaaggccct cctgaccaat gccaagacct tcgggaagcc tacaggtaca cacatggccg
      901 cgccagcgag gaatatgaat gctacgtcat cccagaggag gaagatgagg aagagcctgc
      961 tgatgtcttc tgtgtcactt gcaaaactcc agtgagaact gttgagaagg attttgatat
     1021 acacaaggaa cacgaagtaa ccccaatcaa caaggctctg gaacacgcca aggatgaaat
     1081 tcacaaaaat atgtgcaaat tggaacagca gattattgag atggaaaatt tcgctagcca
     1141 cctggaagaa gtgttcatca ctgtggagga gaattttgga agacaagaac aaaacttcga
     1201 gtgccattac aacgagatct tggaaaccct cgctcagaag tatgaagaaa aaattcaagc
     1261 tctgggggag aaaaagaaag agaagctgga agccctatat ggacagctgg tcagctgtgg
     1321 agagaacctc gatgcctgca gagagctgat ggaaaccata gaggagatgt gtcacgagga
     1381 aaaggttgac ttcttaaagg atgcagtggc tatgactgac agactgggga aattcctgaa
     1441 gaccaagaca gacgtggaac tctctgcaaa gcctgagttt gaagaccaga ccctggactt
     1501 ctcggatgtg gaacagctga tggactccat caataccgtt ccagctccct ctgctccagt
     1561 gataaatccc caggcaccca actcagcaac tggctcctcg gtgcgtgtgt gctggagttt
     1621 atactctgat gacaccgtgg agagctatca gctgtcctac aggccggtgc aggacagctc
     1681 acctggcaag gaccaagcag agttcaccat gacggtcaaa gaaacatatt gctcagtgaa
     1741 aaatcttgag ccaaataccc agtatgagtt ttgggtcata gctcaaaaca ggaccggccc
     1801 cagcccctct agtgagcacg tagtgtatat gacagccccc tctcctccct ctataaaaac
     1861 cgaggcaatc aggagctgtg aagaggccgt gctgatttgc tgggagtctg gaaacctgaa
     1921 tcccgtggac tcctacacag tggagctaat ccaggcagag acgccagaag cctcgggggt
     1981 aactgaatct gttgtaggca tcccaacctg tgaatccctg atacagctac agcctagaca
     2041 cagctacacg atctacgttc gagccctgaa tgtggggggc accagtgcca gaagcaagcc
     2101 tgctacagta cacaccacag gaagctactt ccaactgaac aaggacacct gccacccctg
     2161 gctgaccatt tctgaagacg ggtttaccgt ggttcgaagt gagaagaaga gaagtttcag
     2221 aagggagctg ccacccagca aggcgcagtt tagcaggtgc gttgctgtca tgggaaatct
     2281 aattccggtc cgaggacgcc attactggga ggtggaggtg gatgagcatt tggactacac
     2341 tgttggtgtg gcctgtgaag atgtccctaa acaggaagac ctgggagcaa accgcttgtc
     2401 ctggtgcatg aggcatacat ttgcctccac aaggcaccgg tatgagtttc tgcacaatgg
     2461 gacaactcca gacataagga tcacagttgc tccaaagaag atcggcgtcc tgctagacta
     2521 tgaggactcc aagctgtcct ttttcaacgt ggacattgct cagcacctgt acacgtttag
     2581 ctgcccactc caccaatttg tgcatccctg cttttccttg gaaaagtctg gaggcctaaa
     2641 gatctgcaat ggcatatcag cgccaaagca cgtcactttc ttttaggccc ttctggtatt
     2701 tctgcttttt cctctgtcct gtcccacagc tgccctcacc tcaccggctg aacctggtat
     2761 tcgaggtgcc tgtagccagc agcagctcac gttactgtca gatgttatgc cggagcccat
     2821 ttcacccgat gtggactcat cctgcgtgct gggccctgct gatgccaggg gagcctttat
     2881 cagaacagcc tgttaaatga gggctcctgt ggagtcgaat ccttgtagtg tcaaactgca
     2941 gtttgtgctc tgtaaagtat ttcaagtctc ctaaacttac agacccaggg agagtatcag
     3001 ggaagtcgtg atggtgtcag cagcccctgt acatgtgtga cattttactg tttaccaaga
     3061 acagactagg gaaggcaaga aactctcgac agaaaaagaa gtcagatgct catcttgagg
     3121 ctgccgtggt agactgaata agaatggttc ccaataggct gacacatggg tgggggaggg
     3181 gctgaggtgg cactacttga aaaggattag acctattagg aggtgtggct ttgtggatca
     3241 gaatatacat atgtctcctt tccactactg ctcctgtgac gagtgctgcc gtgcttcctg
     3301 ccatgatgat aatgggtaaa cctctgaaac tgtaagccag cctccaatta catgttgtct
     3361 tttttaagca
//
LOCUS       NM_001438216            2304 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 3, mRNA.
ACCESSION   NM_001438216
VERSION     NM_001438216.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1066385.1,
                                           SRR26643298.5515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000001.1  191914674-191914936 c
            264-932             JAXUCZ010000001.1  191907790-191908458 c
            933-2304            JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2304
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..263
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    262..264
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     exon            264..932
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2145
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425145.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    355..417
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    355..417
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    478..1542
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    478..1542
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    541..603
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    541..603
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    625..687
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    625..687
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    709..771
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    709..771
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    793..855
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    793..855
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    877..939
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    877..939
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    961..1023
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    961..1023
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(976..978,982..984,988..990,994..999,1006..1011,
                     1018..1020,1060..1062,1066..1068,1078..1083,1090..1095,
                     1102..1104,1144..1146,1150..1152,1156..1158,1162..1167,
                     1174..1179,1186..1188)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(976..978,982..984,988..990,994..999,1006..1011,
                     1018..1020,1060..1062,1066..1068,1078..1083,1090..1095,
                     1102..1104,1144..1146,1150..1152,1156..1158,1162..1167,
                     1174..1179,1186..1188)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1027..2079
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1027..2079
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1045..1107
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1045..1107
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1129..1191
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1129..1191
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1213..1275
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1213..1275
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1297..1359
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1297..1359
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1381..1443
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1381..1443
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1465..1527
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1465..1527
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1837..1899
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1837..1899
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1852..1854,1858..1860,1864..1866,1870..1875,
                     1882..1887,1894..1896,1936..1938,1942..1944,1954..1959,
                     1966..1971,1978..1980,2020..2022,2026..2028,2032..2034,
                     2038..2043,2050..2055,2062..2064)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1852..1854,1858..1860,1864..1866,1870..1875,
                     1882..1887,1894..1896,1936..1938,1942..1944,1954..1959,
                     1966..1971,1978..1980,2020..2022,2026..2028,2032..2034,
                     2038..2043,2050..2055,2062..2064)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1921..1983
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1921..1983
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2005..2067
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2005..2067
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            933..2304
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcctaaag aacgccattt tgcaggcctt tgtcctgttc tggatcctct gtccattcat
       61 ttcttcagtc cttccttctt cattcattct gtcctgttcc gctcgccgaa gccacgttat
      121 cctagggttt agtcccaaat gagtcagcat acagccccgc tctgcgggag ctgcctgtct
      181 ggcgaggaca cccgcacaaa cacggttgca gagagcgagg aacgctgggt ttctgcaggt
      241 cttgtccctc ctcagagagt ctgagaaggt ctactcaccg aggccatgga agtggaggct
      301 gcagaggcca agtccccagg cccctgctac aagcgctctg gccgccgtta taagtgcctg
      361 ttttgtacaa agacatttcc aaatgctccc agggcagccc gccatgctgc tacacataca
      421 actacagact gcacagagga ggtgaatgag gtccagccga aggtggatgc agagcccaag
      481 gctgaggaag ccagtggaga caaggtatct gggtcagtag ccaagccccg gccctatgct
      541 tgccctctgt gccccaaggc ctacaagaca gctcctgagc tacgcagcca tggacgcagc
      601 cacactggtg agaagccctt cccgtgccca gagtgcggcc gccgtttcat gcagccagtg
      661 tgcctgcgtg tgcacctggc ctcacacgct ggtgagctgc ctttccgatg cacacactgc
      721 cccaaggctt atggtacact ctctaaacta aagatccacc agcgtgggca cacaggcgag
      781 cggccctatg cctgtactga ctgcggcaag agctttgctg atccttcagt gttccgcaag
      841 catcggcgca cgcatgcagg cctgcgcccc tacagctgcg agcgctgcgg caaggcctat
      901 gctgagctga aggacttacg caaccacgaa aggtcccaca cgggtgagcg ccccttcctc
      961 tgctcagagt gtggtaaaag cttctctcga tcctcttccc tcacatgcca tcagcgtatc
     1021 catgcagccc agaaacccta tcgctgcccg gcttgtggta agggcttcac acagctcagc
     1081 tcttaccaaa gccatgagcg cacacattca ggcgaaaagc ccttcctgtg ccctcggtgt
     1141 ggccgcatgt tctctgatcc ctcgagcttc cgccgccacc agcgggcaca tgagggtgta
     1201 aagccttacc gctgtgagaa atgtggcaag gacttccggc agccagctga cctggccatg
     1261 caccgtcgag tacacaccgg cgaccgaccc ttcaagtgcc tgcagtgtga caagactttt
     1321 gtggcttcct gggacctcaa gcggcatgca ttggtacact caggacagcg gccgttccgc
     1381 tgtgaggagt gtgggcgagc atttgctgag cgagctagcc ttacaaagca cagccgcatg
     1441 cactctggcg agcgtccttt ccactgtaat gcctgcggga aatcctttgt ggtgttatcc
     1501 agcctcagga agcatgagcg cacccataga agcaacgaga ctacgggagc tgccccccag
     1561 caggagttgg tactgggact agcactgcct gtaggtgtcg taggtgaggg ctcagctgcc
     1621 cctgtggcag gtgcagggat aggggatgct ccagcagggc tgctagggtt accgcctgag
     1681 tctggtagtg tagtggccac acagtggcaa gtggtgggca tgactgtaga gcatgtggag
     1741 tgccaggatg ctggcgttgg cgaagctcct agtaccctgg gagatgcagg agaggtgggt
     1801 ggggaggaga ctgatgagaa gcccccacag tttgtgtgtc gagagtgcaa agaaactttc
     1861 tccacactga cattgctacg caggcatgaa cgctcacacc cagagctccg gccctttccc
     1921 tgcacccagt gtggtaagag cttctcagac agggctgggc ttcgtaagca tagccgcacc
     1981 cacagctctg tacgccccta ctcctgttcc caatgtccta aagctttcct gagtgccagt
     2041 gatctgcgca aacatgaacg cacccaccct gtgcccatcg ggacccccat acccctggaa
     2101 ccccttgtgg ctctgctagg aatgccagaa gaagggtcag cctgaagttt atagatctcc
     2161 actacactcc cagaaggcca tccctagtct ccaaacccct gcctctgggc agctagctca
     2221 gttctcgtcc actaagagct gtggacagtg gaagctggta gcatttgtga gaggtactca
     2281 ttaaagcatt ggctttgata ccaa
//
LOCUS       NM_001438220            2541 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 7, mRNA.
ACCESSION   NM_001438220
VERSION     NM_001438220.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.6045.1,
                                           SRR26360181.1606460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               JAXUCZ010000001.1  191921720-191922137 c
            419-500             JAXUCZ010000001.1  191909096-191909177 c
            501-1169            JAXUCZ010000001.1  191907790-191908458 c
            1170-2541           JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2541
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..418
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            419..500
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    466..468
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     CDS             490..2382
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 2 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 2"
                     /protein_id="NP_001425149.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEPREGLLTEAMEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPN
                     APRAARHAATHTTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPK
                     AYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAY
                     GTLSKLKIHQRGHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAE
                     LKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLS
                     SYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADL
                     AMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTK
                     HSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVV
                     GEGSAAPVAGAGIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPST
                     LGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSD
                     RAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGM
                     PEEGSA"
     misc_feature    592..654
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    592..654
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(592..594,601..603,640..642,652..654)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(592..594,601..603,640..642,652..654)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    715..1779
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    715..1779
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    778..840
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    778..840
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    862..924
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    862..924
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(862..864,871..873,910..912,922..924)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(862..864,871..873,910..912,922..924)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    946..1008
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    946..1008
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1030..1092
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1030..1092
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1030..1032,1039..1041,1078..1080,1090..1092)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1030..1032,1039..1041,1078..1080,1090..1092)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1114..1176
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1114..1176
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1198..1260
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1198..1260
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1198..1200,1207..1209,1246..1248,1258..1260)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1198..1200,1207..1209,1246..1248,1258..1260)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1213..1215,1219..1221,1225..1227,1231..1236,
                     1243..1248,1255..1257,1297..1299,1303..1305,1315..1320,
                     1327..1332,1339..1341,1381..1383,1387..1389,1393..1395,
                     1399..1404,1411..1416,1423..1425)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1213..1215,1219..1221,1225..1227,1231..1236,
                     1243..1248,1255..1257,1297..1299,1303..1305,1315..1320,
                     1327..1332,1339..1341,1381..1383,1387..1389,1393..1395,
                     1399..1404,1411..1416,1423..1425)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1264..2316
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1264..2316
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1282..1344
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1282..1344
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1366..1428
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1366..1428
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1450..1512
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1450..1512
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1534..1596
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1534..1596
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1618..1680
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1618..1680
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1702..1764
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1702..1764
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2074..2136
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2074..2136
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2074..2076,2083..2085,2122..2124,2134..2136)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2074..2076,2083..2085,2122..2124,2134..2136)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2089..2091,2095..2097,2101..2103,2107..2112,
                     2119..2124,2131..2133,2173..2175,2179..2181,2191..2196,
                     2203..2208,2215..2217,2257..2259,2263..2265,2269..2271,
                     2275..2280,2287..2292,2299..2301)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2089..2091,2095..2097,2101..2103,2107..2112,
                     2119..2124,2131..2133,2173..2175,2179..2181,2191..2196,
                     2203..2208,2215..2217,2257..2259,2263..2265,2269..2271,
                     2275..2280,2287..2292,2299..2301)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2158..2220
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2158..2220
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2242..2304
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2242..2304
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            501..1169
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..2541
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctgaaca ttctggtcta ccgggactgt gctccccagg cctcttgact tcatgctcta
       61 gtactgactc aatatcatct gacctgccct ccagccccca gtcatcaagg tcctccttac
      121 tgtcttctgt accatgttgg cctccctggc cactggccag ctctagtttg ctctcctcat
      181 gttcccgtag atgttgctct agagatccct ggccagaaaa gccacagcca caaagggcac
      241 aatgtatagc tgctgtcttc tggggccatc ctgactgtcg ccgccgttga ctatcagaat
      301 gcagcctctg atggtctttc agggctttgc ggttggaata ggtcttaaaa cagaaagggc
      361 agctgtaacg gcctgtctca tggttgcatt ggtggttcag gaggctgcca gcatggcggt
      421 ctgcctttcc tgagcatttg gagatcttaa ggccgcgggt ggacctgaga aaggaatatt
      481 gtgagagtaa tggaacctag agaaggtcta ctcaccgagg ccatggaagt ggaggctgca
      541 gaggccaagt ccccaggccc ctgctacaag cgctctggcc gccgttataa gtgcctgttt
      601 tgtacaaaga catttccaaa tgctcccagg gcagcccgcc atgctgctac acatacaact
      661 acagactgca cagaggaggt gaatgaggtc cagccgaagg tggatgcaga gcccaaggct
      721 gaggaagcca gtggagacaa ggtatctggg tcagtagcca agccccggcc ctatgcttgc
      781 cctctgtgcc ccaaggccta caagacagct cctgagctac gcagccatgg acgcagccac
      841 actggtgaga agcccttccc gtgcccagag tgcggccgcc gtttcatgca gccagtgtgc
      901 ctgcgtgtgc acctggcctc acacgctggt gagctgcctt tccgatgcac acactgcccc
      961 aaggcttatg gtacactctc taaactaaag atccaccagc gtgggcacac aggcgagcgg
     1021 ccctatgcct gtactgactg cggcaagagc tttgctgatc cttcagtgtt ccgcaagcat
     1081 cggcgcacgc atgcaggcct gcgcccctac agctgcgagc gctgcggcaa ggcctatgct
     1141 gagctgaagg acttacgcaa ccacgaaagg tcccacacgg gtgagcgccc cttcctctgc
     1201 tcagagtgtg gtaaaagctt ctctcgatcc tcttccctca catgccatca gcgtatccat
     1261 gcagcccaga aaccctatcg ctgcccggct tgtggtaagg gcttcacaca gctcagctct
     1321 taccaaagcc atgagcgcac acattcaggc gaaaagccct tcctgtgccc tcggtgtggc
     1381 cgcatgttct ctgatccctc gagcttccgc cgccaccagc gggcacatga gggtgtaaag
     1441 ccttaccgct gtgagaaatg tggcaaggac ttccggcagc cagctgacct ggccatgcac
     1501 cgtcgagtac acaccggcga ccgacccttc aagtgcctgc agtgtgacaa gacttttgtg
     1561 gcttcctggg acctcaagcg gcatgcattg gtacactcag gacagcggcc gttccgctgt
     1621 gaggagtgtg ggcgagcatt tgctgagcga gctagcctta caaagcacag ccgcatgcac
     1681 tctggcgagc gtcctttcca ctgtaatgcc tgcgggaaat cctttgtggt gttatccagc
     1741 ctcaggaagc atgagcgcac ccatagaagc aacgagacta cgggagctgc cccccagcag
     1801 gagttggtac tgggactagc actgcctgta ggtgtcgtag gtgagggctc agctgcccct
     1861 gtggcaggtg cagggatagg ggatgctcca gcagggctgc tagggttacc gcctgagtct
     1921 ggtagtgtag tggccacaca gtggcaagtg gtgggcatga ctgtagagca tgtggagtgc
     1981 caggatgctg gcgttggcga agctcctagt accctgggag atgcaggaga ggtgggtggg
     2041 gaggagactg atgagaagcc cccacagttt gtgtgtcgag agtgcaaaga aactttctcc
     2101 acactgacat tgctacgcag gcatgaacgc tcacacccag agctccggcc ctttccctgc
     2161 acccagtgtg gtaagagctt ctcagacagg gctgggcttc gtaagcatag ccgcacccac
     2221 agctctgtac gcccctactc ctgttcccaa tgtcctaaag ctttcctgag tgccagtgat
     2281 ctgcgcaaac atgaacgcac ccaccctgtg cccatcggga cccccatacc cctggaaccc
     2341 cttgtggctc tgctaggaat gccagaagaa gggtcagcct gaagtttata gatctccact
     2401 acactcccag aaggccatcc ctagtctcca aacccctgcc tctgggcagc tagctcagtt
     2461 ctcgtccact aagagctgtg gacagtggaa gctggtagca tttgtgagag gtactcatta
     2521 aagcattggc tttgatacca a
//
LOCUS       NM_001438238            5681 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 3 (Dcun1d3), transcript variant 3, mRNA.
ACCESSION   NM_001438238
VERSION     NM_001438238.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5681)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3234259.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000001.1  183716270-183716424 c
            156-231             JAXUCZ010000001.1  183715782-183715857 c
            232-768             JAXUCZ010000001.1  183681017-183681553 c
            769-5681            JAXUCZ010000001.1  183674364-183679276 c
FEATURES             Location/Qualifiers
     source          1..5681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..5681
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
     exon            1..155
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            156..231
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            232..768
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    251..253
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="upstream in-frame stop codon"
     CDS             338..1252
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; DCN1,
                     defective in cullin neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_001425167.1"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
                     /translation="MGQCVTKCKNPSSTLGSKNGDRDPSSKSHSRRGASHREEQVPPC
                     GKPAGDILVNGTKKAEAATEACQLPTSSGDAGRESKTNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREVEGRGALSSGPEGLCPEEQT"
     misc_feature    338..598
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    827..1165
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    827..1165
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    1190..1249
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            769..5681
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgaggag gaggcggcgg ccgcggtggc agaaaaggcg gcggcggcgg gggtagggag
       61 cctggaaacg caagcgggga tggtaggtag tttggacccg ccgggccgcc gtcgtttcca
      121 gaaagggttt gactggagga acctctggag cagctccctg gaattaaggg gctcagacct
      181 gaaggccttt ctgtgcacct tggctgtaga cgataaccat ctgtgcctga ggttggctgg
      241 ctcctctaac tgatggcatg ttgaagtaca tggaccagtg gcagcgaagg gatctgatcc
      301 agagtgggcc actctagaag gccaggctac aatcaccatg ggccagtgtg tcaccaaatg
      361 caagaatcct tcatcaacct tgggcagcaa gaatggagac cgggacccca gcagcaagtc
      421 acacagcagg cggggggcta gccaccgtga ggaacaggtg ccaccttgtg gcaaaccagc
      481 tggggatatt cttgtcaatg ggaccaagaa agcagaggct gccaccgagg cctgccagct
      541 gccaacttct tctggagatg cagggaggga gtccaagacc aatgctgagg agtcttcctt
      601 gcagaggttg gaagaactgt tcaggcgcta taaggatgag cgggaggatg caattttgga
      661 ggaaggcatg gagcgctttt gcaatgacct atgtgttgat cctacggagt ttcgagtgct
      721 gctcttggcc tggaagttcc aggctgctac catgtgcaaa ttcaccagga aggagttttt
      781 tgacggctgt aaagcaataa gtgcagacag cattgatggg atctgtgcac gtttccctag
      841 cctcttaaca gaagccaaac aagaagataa attcaaggat ctctaccggt ttacatttca
      901 gtttggcctg gactctgaag aagggcagcg gtcactgcat cgtgaaatag ccattgccct
      961 gtggaaatta gtatttacac agaacaatcc tccagtattg gaccagtggc taaatttcct
     1021 aacagagaac ccttcgggaa tcaagggcat ctcccgggac acttggaaca tgtttcttaa
     1081 cttcactcag gtgattggcc ccgacctcag caactacagt gaagatgagg cctggccgag
     1141 tctctttgat acctttgtgg agtgggaaat ggagagaagg aaaagagaag tggaagggag
     1201 aggtgcactc agctcagggc ccgagggctt gtgtccagaa gagcagactt agctgctctg
     1261 ttccaggagc agcactgagg atctgcctgc tgccctgcag ccaagtgagg aattggacct
     1321 ttctggaaat taccgaagat ccggatattt tctactttca cctttctctg ccttgtattt
     1381 gaaagggctc taaaatgctg tatcatgttt taggcacttt cttcattttt ttttttgggt
     1441 tattttggtt atttcttttt gggggtggga aatcccccca aaatatttga acctggctac
     1501 atgttgtgta cctttttttg aagccttcag atagaataag cctgccattt cttgcacaac
     1561 tttattagat ttgttttgtt tttgtggggg agggtgtaga cccgggttgg ggagtgggac
     1621 tgttaggttg aattaacatt acaaaatgat acagtgccag atctcagttt tgcatattat
     1681 ttttcagggc aggtctgtac tgtgtgtagt gctgtttaca tggttgaatt taggttgtaa
     1741 taattatttt aaaagattta cacagatatg aatatagcag tgttaactgt tagccacatt
     1801 gcattaattt ccagacagtt tggagctctt ggagagccaa ggccaaggcc cgtcaggagc
     1861 atttgcagtc ttgacacccc accccatccc tttacgctaa tttatccaaa gccctatctc
     1921 cctcacttcc tgctcattcc ttctctaacc tatattgcat ttcatgttta acttatccat
     1981 caacatgctg tacctgtcag tcaagtgagc agttttgttt tgttcgaaca cattgtactg
     2041 aaaaccactt aagcattgaa tgcagagaaa gcagtgctac ctcagttttg ctggaagtag
     2101 acttctttga tattttcttt gatgtttttg tattttcatg tcataagtgg aaatacttct
     2161 ttttccccct tttcatttgc cttggagcca aagtttccgt tgttgtgggt ggtgagaaaa
     2221 gtgtgcctgc ctgcctgcct gccagctgac cggacagaaa gctgtggcat ggggctctgc
     2281 tccagactgc ttttctttag tttttgttga gtatcactag cttacttgtc tggcaagtgc
     2341 agaagcctga ggctggcctg aactctgcca aacaaattat ccacgtgtat tgaatcatta
     2401 aatgtgtgcc ctctccctct ttgctgcgcc catgttgtca cttaacccca ggagttattt
     2461 attgtctttt gttagtgtca ggctcacctg gggtgacgtg atggctgttt aggtttacac
     2521 ggccctctgc tctttcccta ctcccagaca tgtatatata catatataag atatgtatat
     2581 attttacctt ataaaatata tatatacaca tatatgtatc tatatccctg cgtttgtctg
     2641 ctaaaactgg ccatgaaaga gggagctgcc ttcaatctgt agtttaagaa gatgccaggg
     2701 agcatcataa atggaggctg ttgtatatta atttagattt ttttcactaa aaagaacatg
     2761 aatgaatttg ctcgcaggaa ggaggaacca gttctctaga ccccatgctc actctacaag
     2821 accagctttg gtcaagctgc ccctggggcc tgaagagctg actatctcct gcctgttcca
     2881 ttagaggacc atcttgataa tttcccctta aaaatatcct caaaaatgta ctggaaggtg
     2941 ggtggcagga gcttgtacag ttcagcttcc aacatttcgg aacagattta aaagggaatc
     3001 ttttaataaa taaaagctac aaaaatattt atactcttga tacaatgaaa aagtgtctat
     3061 taaatatttg gaattttctt ccttgattag tctgccccaa atcctgggta tgtttctcaa
     3121 cctgggtaag aattgcatgc tttgagttct tcatgagtct tatagctctg ggcacttatc
     3181 tctataaaga tgattatttt aggagatgac agtcatattt cctgaagttg gtattgacac
     3241 agggaacatt tttgtaagcc tcacaattgt cctttcttga gggatgagat gatgaaaatc
     3301 agccacagac ttaagatagt gctggaaggc acaagtggct attgggccag atgtacccct
     3361 ttcttctagc tgaaataaga gacatccttg agttagaatc taggagccca gcagtttctg
     3421 agggcacagc tacatacctt tggataaaag ctcaccaaac cagttagttg ttcctaattc
     3481 aggattagaa gaagtccaat gagggaaaaa gcggagttag gtaagtaaga ctttctgtcc
     3541 cagataagaa agggtgggtg tatggcgggg aagtgccaag agagggagtc tgccaagggc
     3601 cccatggact caaggaacta gattccttcc caactgggta gatttttttt taactgccca
     3661 gtttctccaa ccccaatgcc tgcaccccaa cccccagcca tttagaaatt gtgattatat
     3721 ttttaatcat ctgttgctga gaaagcagag aaaggaacag tcagggaggg actctgggtt
     3781 ctctgtgcag tagttttgtt ttactgagag actctcagtg aggtgtacag tttgtagtta
     3841 acacttctgg gatacagaaa agcctctgtt cactcagcct cagacaggct tgctgagaac
     3901 tgggtggatg agcagtggct gggagccaaa ttgcccctca ggtaagctag ctttgtgact
     3961 tgggtgatgg gtgatgtggg gaggtgcgat atgtgggtgc cattttgaaa ttctgcaatg
     4021 tttaagcatt actacacaga atatgttgaa aattgcttac tttgggcaag tgactttttg
     4081 agtttctatg gtatttcttt agtaacttat tagcaagctg gtatgagata aaaagttact
     4141 ttactgaatt ctttccccta gtcttccttg ccatacttga atgtatcatt cttaatgaca
     4201 ctttgctgta cttctggggg ttgcctcagc aactctctct tcactggcag atgtgccaac
     4261 atgtatgttg ggtccagaag tctgtatgta cccatcttat aaagaagtct ccagagctgg
     4321 ctgaaattcc aaatttcagc caaagctttg ggccaaggga aagatagtag aaaatgtgca
     4381 aagcagtact gttcatgtta gatggatgga tacagtgaag aattaagcct cacacagaat
     4441 tagcttgaaa cagtactgtc acctagggtc tggtctctag gctagatcag gttatgggac
     4501 cctataaatt atgtaattag actatacatt ggtgggaagt tgctaagata aagacttgct
     4561 caaaagacta acagcaaaag atgtgtgtat tgaaatgtat agtttgctgt agttcaagtg
     4621 gagtcttcag tgcagcaggt agacctagtt atacagttat gtatggaatg gaaagcaaac
     4681 tactgttaaa cggtttttgt ctctcccctg ccaccttctt tagatttctt aatctcctgt
     4741 gtgtgtcagg atggctagtg atgacctgaa catctataac tgacaaaggt ctacttgggg
     4801 gactaaagca gtatttagct taaatatgtg aaagaacaaa attatcaaaa gatgttgatt
     4861 aggattattt aaggtcatgt gacattgatc ttttcttcta cgtcatggtt cttgccacac
     4921 tcctattctg agtttatttt tttggtaagc tgtagttgta gcccataaca gtttgacctg
     4981 gcctaggact acatgctggg gatgctcatc aggacctccc ccccccccct tttttttttt
     5041 tcaaagaagg atgcttgagc attgggcaca gatgctgagg tggtttgact agctgaagtt
     5101 ctgattcggg tgttggggca tcatattctg tttctcttgg gaacccagcc tgctctcata
     5161 gatacctact tctatcacat accctgagca ttgccaaaag aagccattca gcagctgctg
     5221 tttttctctc agcacaaata tatttgctac agaagaacta tcttttctct aatactaatt
     5281 ccccgtccag tcctcagaat ctgattaact gttcttccct gctgcactga atatgttcga
     5341 gattttaaag agggaatttg aagcaatagg caaacagggc ttggttgaat tggtcttgca
     5401 tatatcctgt cttaagccaa tgaggtgatg agtccactgc tcatgtgacc ctgcaccttt
     5461 gtggatcctt cttggtttgt gaccagtgta cgtttcttga ggttgtacaa acttgacaaa
     5521 agttaatact tttgtattct ctgcactgtt gcactcttca aatagccccc tgaatattac
     5581 cttgatatac acatttttgt ctttgatgtc tacagtattt ttcttttttt tttaaatttg
     5641 aaggttatct gctgttggat tcaataaatt tgtttaccta a
//
LOCUS       NM_001438142            1643 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 9,
            mRNA.
ACCESSION   NM_001438142 XM_063266801
VERSION     NM_001438142.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063266801.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2937614.1,
                                           SRR26643293.3138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000001.1  105098879-105099086
            209-346             JAXUCZ010000001.1  105130305-105130442
            347-514             JAXUCZ010000001.1  105130564-105130731
            515-687             JAXUCZ010000001.1  105131624-105131796
            688-984             JAXUCZ010000001.1  105132438-105132734
            985-1097            JAXUCZ010000001.1  105133588-105133700
            1098-1212           JAXUCZ010000001.1  105134128-105134242
            1213-1311           JAXUCZ010000001.1  105134333-105134431
            1312-1483           JAXUCZ010000001.1  105135522-105135693
            1484-1643           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1643
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..208
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     CDS             178..1617
                     /gene="Tulp2"
                     /note="isoform 9 is encoded by transcript variant 9;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 9"
                     /protein_id="NP_001425071.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MPNTPPHDSLGVGSPFLQENVPQAHLPSGAHSALVTMSYVGDGS
                     GERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVTMEDIPVISRPPKTHLANR
                     RRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENSDRVHGDSASCNMEENTAK
                     KNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGDTSNHSAWNMTCPMPRTPG
                     PRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSYYLYLEAEDGVAHFLLAGR
                     KRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTKFTIFDNGVNPERNYWIPDSA
                     RIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDQDSILSRVQKGAR
                     HGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNI
                     FTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    <226..>585
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    <226..>585
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    871..1599
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    871..1599
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            209..346
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..514
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..687
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..984
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1097
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1212
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1311
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1483
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1643
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaggaag ctttcattgt ctaaactctt cctgggagta gaggccttaa aggctgagtc
       61 tccgttctta tctgtgggtt cctaaggtcc acagagcagt agcaccctgc agaacagtgt
      121 gggtgcatct gaaaagctga gctcctgcat gtcatgggac tatcctgagc tgctgctatg
      181 cctaacacac ctccccatga ctccctaggt gttgggagcc ctttcctcca ggagaacgta
      241 ccacaggcac atctgccctc aggggcacac agtgcccttg tcaccatgag ctatgtcgga
      301 gatgggagtg gtgagcgggc ccctctactg tcacccagag gagcagtata cactcggggc
      361 aatgggcctg cggtccgcca tctctgctgg ctcccagaca gctccgattc agatgtggag
      421 gaagtgacca tggaagacat tcctgtcatc tcccgacctc ccaagacgca cctggcaaac
      481 cgacgcaggg gctggttagc ctccccagga cccgggatca gtgaagagga agaggttgaa
      541 cccaaggatg ccagagttga agacaagaca cccagcccag acccagaccc tacagaaaac
      601 tctgatagag ttcatggaga ctcggcatcc tgcaatatgg aggaaaacac agccaaaaag
      661 aatatagaaa cagcctctgg cattggggat gaagacccgg agaagaaaga ggccacagag
      721 tctacagaga caaacaatgc cctagtggca tccaaggtct tgcaaggaga tggtgacacc
      781 agtaaccaca gtgcttggaa catgacctgc cccatgcctc gcactccagg tcctcggctc
      841 ggggaggaca tggaagctta cgtgttgctc cctgcacccc gagaacacat ggtgcagtgc
      901 cgcatcgtcc gaaacaagca tggagtggac aagggcatgt tcccttccta ctacctctac
      961 ctggaggcag aggatggtgt agcacatttc cttctggctg ggcggaaaag gaaacgaagc
     1021 aaaacttcaa attacctcat ctccctggac cccaaagaca tgtctcgcaa tgggaacaac
     1081 tttgtaggca aagttagatc taatgtcttg ggcacgaaat tcaccatctt tgataatggg
     1141 gtgaaccctg agcgtaacta ctggattcca gacagtgccc ggatcagaga ggagttggga
     1201 gttgtatgtt atgagaccaa tgtcttggga ttcagggggc ctcggaaaat gaccgtgatc
     1261 ctcccaggaa tggacagccg gaagcagagg atgaaagtac aaccacaaaa tgatcaggat
     1321 tcaatactga gtcgcgtaca gaaaggcgct agacatgggc tgctcctact gcagaacaag
     1381 gccccatcgt ggagcgacga aagcggcgca tacgtactca attttcatgg tcgcgtcacg
     1441 cgggcttctg tcaagaactt ccagatagtg cacccggatg aaccggacca cctggtgctc
     1501 cagtttggcc gtgtagcacc aaacatattc acgatggatt tccgatatcc tctttgcccg
     1561 ctccaagcct tcgccatctg cttatccagt ttcgatggga aactggcgtg tgagtaactg
     1621 aataaaatac catccctcac caa
//
LOCUS       NM_001438194            2849 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 4, mRNA.
ACCESSION   NM_001438194 XM_039113189
VERSION     NM_001438194.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039113189.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.2151.1,
                                           SRR26643294.3239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000001.1  162082635-162082764 c
            131-409             JAXUCZ010000001.1  162081503-162081781 c
            410-2849            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2849
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..130
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     exon            131..409
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    301..303
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            410..2849
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..1479
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425123.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     418..468
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     469..1476
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    595..657
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    604..675
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    604..675
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    640..642
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <670..>1335
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <670..>1335
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    673..738
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    685..747
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    685..747
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    745..810
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    748..816
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    748..816
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    814..879
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    817..894
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    817..894
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    829..831
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    895..975
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    895..975
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    895..957
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    973..1038
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    976..1032
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    976..1032
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    988..990
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    1039..1110
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1039..1110
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1039..1101
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    1108..1176
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    1111..1185
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1111..1185
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1183..1248
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    1186..1260
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1186..1260
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1258..1323
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    1261..1332
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1261..1332
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtg ggtgctgtcc
       61 cgaagcgcag cgagatcggc gccggtttgg aggtttggag cccgggactt caacctcacc
      121 gccccatcct gttagaaagg ccacggtttg cctgcatccg gcctgcttgt ggcccctgtc
      181 cctggttggg ctgtgatgag aagaggcctt ccacacacta gtttcgaaag gcacgccaat
      241 ggcccacgta ggatacgggc gtgtggctga aacccgttga gattcggtca ctgttgtgga
      301 tgaagtgaga agaactctat ccctcgggag cggagcgcac aagtggtggt gaccagcgtg
      361 gcgagcttag ctgaaagcgg ctcccgccca cacttggccg ggcccagagg tgtcaccatg
      421 ttgtgcaccc tgttcctgct actgctggcc ctgggcacag tgcagacaac tcggccatgt
      481 ttccctggct gccagtgtga ggaagagacg tttggcctct ttgacagttt cagcctgatc
      541 cgagtggact gcagcagcct gggcccccac attgtgcctg tgcccatccc tctggacaca
      601 gcccacctgg acctgtcttc caaccggcta gaaaccgtga atgagtcagt cctgggaggg
      661 ccaggctata ccacactggc tggcctggat ctcagtcaca acctcctcac cagcatcacg
      721 cccactgcct tctcccgcct tcgctacctg gagtcactgg acctcagtca caatggcctg
      781 gcagccctgc cagcagaggt tttcaccagc tcccccttga gtgatatcaa cctgagccat
      841 aatcgactta gagaggtctc aatatctgcc ttcaccaccc acagccaggg gcgggcactg
      901 cacgtggacc tatcccacaa tcttatccac cgcctgctcc cctatccagc cagggccagc
      961 ctgtccgcac ctaccattca gagcctgaac ctgtcctgga accggctccg agccgtgccc
     1021 aatctccgag acctacccct gcgttacctg agcctggatg ggaaccctct ggctaccatc
     1081 aacccaggcg ccttcatggg gctggcgggc ctcacccacc tttcactggc aagcctacag
     1141 ggtatcctcc agctaccacc ccatggcttc cgagagctcc caggccttca ggtcctggac
     1201 ttgtctggta accccaagct caagtgggca ggagccgagg tattttcagg cctgggtttg
     1261 ctgcaagaac tagacctgtc tggctccagc ctggtgcccc tgcctgagac gctgctacat
     1321 cacctccctg ctttacagag tgtcagtgta ggccaagatg tgcagtgccg gcgtctggta
     1381 cgggagggtg cctaccaccg ccaacccggt tccagcccta aggtagtcct gcactgtgga
     1441 gacacccagg aatctgccag gggcccagac atcttgtgac gaatggtgtg gcctgaggcc
     1501 acttgacaga ctgctgtcct gggcttgctc aggtccccac taatatttta atgtgccaat
     1561 gcctgtggag tgtctacagg tctaagtggc agccatctca gtgaagatgt gggccaagga
     1621 tagttttcat acctagggcc tatacccaat aacagaatct gcccgcttgt ctcagcggct
     1681 cacttccctg agctatgagc aaagggactt cgatgccaaa ccagactttg gtcccttcct
     1741 gagccctgcc ccagttatct ctaagtgcct tcccttttgc ccagactgac ctgacccatg
     1801 atgtaaggac cgtaggggag caccaccact gcaaaggctg actaaggtct gttgggctaa
     1861 aggtctcttt gagcccagtg tctatagtca caccttcttt gctctgggcc caggaggcct
     1921 acttcttctt tttctcgtgg aatcctggaa tcttaaagat aaaagaacct agaaagaaaa
     1981 tcaaacccat tttccttgtg gggcagatgg taatatggga ctgagaacag caaacctggg
     2041 gtcttggaga ggagcccagc ctcctgttga ggttgagagc tctgtcaccc tcccttcccc
     2101 tgctgggtac cctgttacta ttgtctgtac tgttttccat tgtgcccagc agtagcaaca
     2161 acaaggtcac agaggtggga actctaggtc cagtggccag cttatggtgt gagcgtagtc
     2221 agtccccctt tcagagcctc aggaagcttg gagcacctca gtctcaagcc tgtcagttcc
     2281 ttactctggg atgaccccca acatcaagac tggaaacata cacattctcc ccagggacac
     2341 agtcttaaga tgcttttcta agaagtcaat gcagttgtga ccatgtggcc atgagctcca
     2401 agggactcgt gggcttggtg tccatgggcc ggagcccaaa gacccgcttc cccctccaag
     2461 agtatggcag aaagggtctc ccatgcacat tgtgctcccc gccagggcca catctcagct
     2521 ctccagctct ggattctttc ttctgttttc attttatgag tcgttgtctt ttttaaaatg
     2581 aactgtttaa cccccacctc tgctggccag gggatggaaa ggaagataaa tgtatttgtt
     2641 cgcttttgta agactctgtt ctgggtgtgg gctggggatc ttgggaagaa gccagttggc
     2701 tatcagtaac catgtgggca ttggggctgg tccctgggat gctcaaaagt cagtgagagc
     2761 tctgtcttct cacactagcc cagcccagcc caccccgtga ctggtccttg gtttaataaa
     2821 cacatgtaag agctctttcc atcactgga
//
LOCUS       NM_001438143            1591 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant
            10, mRNA.
ACCESSION   NM_001438143
VERSION     NM_001438143.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1591)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3166.1,
                                           SRR26360181.1901616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-135              JAXUCZ010000001.1  105128567-105128618
            136-273             JAXUCZ010000001.1  105130305-105130442
            274-441             JAXUCZ010000001.1  105130564-105130731
            442-614             JAXUCZ010000001.1  105131624-105131796
            615-932             JAXUCZ010000001.1  105132438-105132755
            933-1045            JAXUCZ010000001.1  105133588-105133700
            1046-1160           JAXUCZ010000001.1  105134128-105134242
            1161-1259           JAXUCZ010000001.1  105134333-105134431
            1260-1431           JAXUCZ010000001.1  105135522-105135693
            1432-1591           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1591
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..135
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    96..98
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            136..273
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1565
                     /gene="Tulp2"
                     /note="isoform 10 is encoded by transcript variant 10;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 10"
                     /protein_id="NP_001425072.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDV
                     EEVTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDP
                     TENSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQ
                     GDGDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGM
                     FPSYYLYLEAEDGVAVRSSPLGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGK
                     VRSNVLGTKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILP
                     GMDSRKQRMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVT
                     RASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE
                     "
     misc_feature    798..1547
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    798..1547
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            274..441
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..614
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..932
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1045
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1160
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1259
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1431
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1591
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agagaccttg gaggatgaat tctctggtgt gaggctgcag
      121 aagctggaac aacaggtgtt gggagccctt tcctccagga gaacgtacca caggcacatc
      181 tgccctcagg ggcacacagt gcccttgtca ccatgagcta tgtcggagat gggagtggtg
      241 agcgggcccc tctactgtca cccagaggag cagtatacac tcggggcaat gggcctgcgg
      301 tccgccatct ctgctggctc ccagacagct ccgattcaga tgtggaggaa gtgaccatgg
      361 aagacattcc tgtcatctcc cgacctccca agacgcacct ggcaaaccga cgcaggggct
      421 ggttagcctc cccaggaccc gggatcagtg aagaggaaga ggttgaaccc aaggatgcca
      481 gagttgaaga caagacaccc agcccagacc cagaccctac agaaaactct gatagagttc
      541 atggagactc ggcatcctgc aatatggagg aaaacacagc caaaaagaat atagaaacag
      601 cctctggcat tggggatgaa gacccggaga agaaagaggc cacagagtct acagagacaa
      661 acaatgccct agtggcatcc aaggtcttgc aaggagatgg tgacaccagt aaccacagtg
      721 cttggaacat gacctgcccc atgcctcgca ctccaggtcc tcggctcggg gaggacatgg
      781 aagcttacgt gttgctccct gcaccccgag aacacatggt gcagtgccgc atcgtccgaa
      841 acaagcatgg agtggacaag ggcatgttcc cttcctacta cctctacctg gaggcagagg
      901 atggtgtagc agtacgctcc agccctttgg ggcatttcct tctggctggg cggaaaagga
      961 aacgaagcaa aacttcaaat tacctcatct ccctggaccc caaagacatg tctcgcaatg
     1021 ggaacaactt tgtaggcaaa gttagatcta atgtcttggg cacgaaattc accatctttg
     1081 ataatggggt gaaccctgag cgtaactact ggattccaga cagtgcccgg atcagagagg
     1141 agttgggagt tgtatgttat gagaccaatg tcttgggatt cagggggcct cggaaaatga
     1201 ccgtgatcct cccaggaatg gacagccgga agcagaggat gaaagtacaa ccacaaaatg
     1261 atcaggattc aatactgagt cgcgtacaga aaggcgctag acatgggctg ctcctactgc
     1321 agaacaaggc cccatcgtgg agcgacgaaa gcggcgcata cgtactcaat tttcatggtc
     1381 gcgtcacgcg ggcttctgtc aagaacttcc agatagtgca cccggatgaa ccggaccacc
     1441 tggtgctcca gtttggccgt gtagcaccaa acatattcac gatggatttc cgatatcctc
     1501 tttgcccgct ccaagccttc gccatctgct tatccagttt cgatgggaaa ctggcgtgtg
     1561 agtaactgaa taaaatacca tccctcacca a
//
LOCUS       NM_001438200            2507 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), transcript
            variant 3, mRNA.
ACCESSION   NM_001438200
VERSION     NM_001438200.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.3602.1,
                                           SRR26643295.3454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  168149213-168149262 c
            51-104              JAXUCZ010000001.1  168148417-168148470 c
            105-580             JAXUCZ010000001.1  168141182-168141657 c
            581-676             JAXUCZ010000001.1  168139744-168139839 c
            677-907             JAXUCZ010000001.1  168138006-168138236 c
            908-930             JAXUCZ010000001.1  168135410-168135432 c
            931-1031            JAXUCZ010000001.1  168134230-168134330 c
            1032-1058           JAXUCZ010000001.1  168133975-168134001 c
            1059-2507           JAXUCZ010000001.1  168132277-168133725 c
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2507
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..50
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            51..104
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            105..580
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    122..124
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="upstream in-frame stop codon"
     CDS             161..1696
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 3;
                     tripartite motif-containing protein 5"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform 1"
                     /protein_id="NP_001425129.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MASEFVMNLKEEVTCPICLDLMVEPVSGDCGHSFCQACITLNYE
                     SSKCNQDEFICPVCRVSYLFKNLRPNRHVANIVQRLKEFKSSPEEEPKVLSCARHGEK
                     LQLFCKKDMMPICWLCERSQEHRGHQTVLIEEVVQEYKEKLQAALQKLMADKKEFENW
                     KDDLQKERTYWQNQIQKDVENVQSEFKGMRDIMDSEEKKELQKLMQEKEDIMSSLEES
                     ENEYSQQSKLLGDLILDVEHQLQCSATEMLQGVENTIKRSHTFSMRKPKTIPKEQRRV
                     FRAPDLQGMLQVLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARP
                     TENCHAGVLGYPAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPL
                     FRLNLSNDSHSRLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLM
                     VRPCRVGIFLDCAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICW
                     PDS"
     misc_feature    182..394
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    182..394
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    order(206..211,215..220,326..331,335..337)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    order(206..211,215..220,326..331,335..337)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    443..559
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    443..559
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    554..>859
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    554..>859
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    1028..1681
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     misc_feature    1028..1681
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            581..676
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            677..907
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            908..930
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1031
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1058
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..2507
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtgtgg cagctgccct gaactacatc atcctttcgg ttctcatcct agagatccag
       61 aatgttgttt tctaagacag tcactttcct gacagcagag ctaggcacct gagcagacgt
      121 gtgaggagtc agtagagtca gacacaggat cacagcaact atggcttcag aattcgtgat
      181 gaatttaaaa gaggaggtga cctgtcctat ctgcctggac ctgatggtag aacctgtgag
      241 tggagattgt ggtcacagct tctgccaagc ctgcatcacg ctgaactatg aatccagcaa
      301 atgcaatcag gatgagttca tttgccctgt gtgccgagtt agttacctgt ttaagaacct
      361 gaggcccaat cgacatgtgg ccaacatagt gcagaggctc aaagagttca agtccagccc
      421 agaagaggag ccgaaggtgc tttcttgtgc aaggcatgga gagaaactcc agctcttctg
      481 taagaaggac atgatgccca tctgctggct ttgtgagcga tctcaggagc accgtggaca
      541 ccaaacagtt ctcattgaag aggtggtcca ggagtataag gagaagctgc aggcagctct
      601 gcaaaagctg atggcagaca agaaagaatt tgagaactgg aaagatgacc ttcaaaagga
      661 gagaacttac tggcagaatc aaatacagaa agatgtggaa aatgtccagt cagagtttaa
      721 aggaatgaga gatatcatgg actctgagga gaagaaggaa ttgcagaagc tgatgcaaga
      781 gaaggaagac attatgagca gcctggaaga gtctgaaaat gagtattctc agcagagtaa
      841 gttgctagga gacctcatct tagatgtgga acatcagtta caatgctcag ccacggaaat
      901 gctgcagggt gtagagaaca ccataaaacg gagtcatact ttttcgatga ggaagcccaa
      961 aaccatcccc aaggaacaaa gaagagtgtt ccgagcccct gatctgcaag gcatgctgca
     1021 agtgttacaa gaggtcacag aggcccaacg ctactgggtt caagtgacgc tggttgaaag
     1081 caacaatcca aacattttca ttaccgccga caaaagacag atacgatatg aagaccacca
     1141 agcaagacat tttgcccgtc cgactgaaaa ctgtcatgca ggtgtcctgg gatacccagc
     1201 tatccaatca ggaaaacact actgggaagt agatgtgtct ggaaaaggtt cttgggttct
     1261 gggattaagt gatggaagct acctctttaa tccaatattt cgttcaaatg cagaaagacc
     1321 cccaaacccc cccttatttc gtttgaatct tagtaatgat tcacattctc gtttgagtct
     1381 tagtaatgat tcacattatc aacctaaata tggcttctgg gttatagggc tgtggggaaa
     1441 ttctgtgtat aatgcttttg aggagtgtac gttcacaggc aagcccagtg tgttgaccct
     1501 ctctctgatg gtccgaccct gtcgtgtcgg tattttcctc gactgtgcag ctggcaccct
     1561 ctcgttttac aatatttcca accatggcac tcttatctac agattctgtg caggttcctt
     1621 tcctgatagg gtttttccat attttaaccc catgggaagt tcagagccat tgacaatatg
     1681 ctggccagac tcttaatctt cactgtctct gtgcatggtc tctggtcctg atgtgtatgt
     1741 catgtgcctg agctcatcag cactatttta tcgttttgtt catgtctcta atctttcatt
     1801 ggaaaatata ttcatttctc taggccatat tctcagtttc ttggggtatt ttttgtcttt
     1861 gttttgtttt gtttttaggt gagactaaca aatcacttcc catatagtca aggacaaatg
     1921 tctagtgctc actgcgtaag ataacaccga tgcaaaattc ctcttattct tcatgccaga
     1981 gatggaaggc aaggccttgt gcacggtgag gatgtgctcc accgctgagc tgtttgcttc
     2041 agctgtcatg tccctataac ctcattcggc ccatcaatga aagattaaag aaggttcttc
     2101 gacaacttgt ctattcatgc tgaaaattat atataggagt ctctgcttaa gaaatgcacc
     2161 ctgagctgta ggccaaagaa tgaaggagaa gcatcacaag aagccttatc actgtgacta
     2221 aattaagtga tcattaagac tgtgcatcag tcttgcctgg gagctcatac ctgccatcct
     2281 gcatctggga agttgtggca ggaagattgc tgtgtatttg aagccaccct tgtatagagt
     2341 taagagcctg cttaaaaaaa ataatcaaga atatgtataa aaaccactac tctattttgt
     2401 tctaagaaat agaataacta gatttcagaa ttgcagggtt tgggtcgttt tcacaatttg
     2461 taaataaatg tttactaaaa ataaatgtta acttcatagc tgtccaa
//
LOCUS       NM_001438145            1672 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant
            12, mRNA.
ACCESSION   NM_001438145 XM_063266811
VERSION     NM_001438145.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063266811.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.660640.1,
                                           SRR26360181.1685240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000001.1  105129723-105129959
            238-375             JAXUCZ010000001.1  105130305-105130442
            376-543             JAXUCZ010000001.1  105130564-105130731
            544-716             JAXUCZ010000001.1  105131624-105131796
            717-1013            JAXUCZ010000001.1  105132438-105132734
            1014-1126           JAXUCZ010000001.1  105133588-105133700
            1127-1241           JAXUCZ010000001.1  105134128-105134242
            1242-1340           JAXUCZ010000001.1  105134333-105134431
            1341-1512           JAXUCZ010000001.1  105135522-105135693
            1513-1672           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1672
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..237
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            238..375
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1646
                     /gene="Tulp2"
                     /note="isoform 11 is encoded by transcript variant 12;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 11"
                     /protein_id="NP_001425074.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDV
                     EEVTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDP
                     TENSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQ
                     GDGDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGM
                     FPSYYLYLEAEDGVAHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLG
                     TKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQ
                     RMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNF
                     QIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    900..1628
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    900..1628
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            376..543
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..716
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1013
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1126
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1241
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1340
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1512
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1672
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtaggtt aagggagggg ctgttagact ggcttataat atttcagtgt tggggaggac
       61 cctaatgcat cgtggtggta gtggggcacg cggtagagca taggggcgtg gcttacttga
      121 gtgtgggcct ttatgaggga acataggggg agccttgtgg atccttctgc agaggattga
      181 ttgggttgtg ggtttcttaa aagctattga gaacatccag tcctgtggag tacccaggtg
      241 ttgggagccc tttcctccag gagaacgtac cacaggcaca tctgccctca ggggcacaca
      301 gtgcccttgt caccatgagc tatgtcggag atgggagtgg tgagcgggcc cctctactgt
      361 cacccagagg agcagtatac actcggggca atgggcctgc ggtccgccat ctctgctggc
      421 tcccagacag ctccgattca gatgtggagg aagtgaccat ggaagacatt cctgtcatct
      481 cccgacctcc caagacgcac ctggcaaacc gacgcagggg ctggttagcc tccccaggac
      541 ccgggatcag tgaagaggaa gaggttgaac ccaaggatgc cagagttgaa gacaagacac
      601 ccagcccaga cccagaccct acagaaaact ctgatagagt tcatggagac tcggcatcct
      661 gcaatatgga ggaaaacaca gccaaaaaga atatagaaac agcctctggc attggggatg
      721 aagacccgga gaagaaagag gccacagagt ctacagagac aaacaatgcc ctagtggcat
      781 ccaaggtctt gcaaggagat ggtgacacca gtaaccacag tgcttggaac atgacctgcc
      841 ccatgcctcg cactccaggt cctcggctcg gggaggacat ggaagcttac gtgttgctcc
      901 ctgcaccccg agaacacatg gtgcagtgcc gcatcgtccg aaacaagcat ggagtggaca
      961 agggcatgtt cccttcctac tacctctacc tggaggcaga ggatggtgta gcacatttcc
     1021 ttctggctgg gcggaaaagg aaacgaagca aaacttcaaa ttacctcatc tccctggacc
     1081 ccaaagacat gtctcgcaat gggaacaact ttgtaggcaa agttagatct aatgtcttgg
     1141 gcacgaaatt caccatcttt gataatgggg tgaaccctga gcgtaactac tggattccag
     1201 acagtgcccg gatcagagag gagttgggag ttgtatgtta tgagaccaat gtcttgggat
     1261 tcagggggcc tcggaaaatg accgtgatcc tcccaggaat ggacagccgg aagcagagga
     1321 tgaaagtaca accacaaaat gatcaggatt caatactgag tcgcgtacag aaaggcgcta
     1381 gacatgggct gctcctactg cagaacaagg ccccatcgtg gagcgacgaa agcggcgcat
     1441 acgtactcaa ttttcatggt cgcgtcacgc gggcttctgt caagaacttc cagatagtgc
     1501 acccggatga accggaccac ctggtgctcc agtttggccg tgtagcacca aacatattca
     1561 cgatggattt ccgatatcct ctttgcccgc tccaagcctt cgccatctgc ttatccagtt
     1621 tcgatgggaa actggcgtgt gagtaactga ataaaatacc atccctcacc aa
//
LOCUS       NM_001438133            1459 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus proline rich and Gla domain 2 (Prrg2), transcript
            variant 3, mRNA.
ACCESSION   NM_001438133 XM_008759396
VERSION     NM_001438133.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1459)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759396.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1446145.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  104679769-104679813 c
            46-219              JAXUCZ010000001.1  104678978-104679151 c
            220-373             JAXUCZ010000001.1  104678247-104678400 c
            374-555             JAXUCZ010000001.1  104677743-104677924 c
            556-595             JAXUCZ010000001.1  104677511-104677550 c
            596-737             JAXUCZ010000001.1  104673619-104673760 c
            738-866             JAXUCZ010000001.1  104671671-104671799 c
            867-1459            JAXUCZ010000001.1  104670748-104671340 c
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1459
                     /gene="Prrg2"
                     /note="proline rich and Gla domain 2"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     exon            1..45
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..219
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    166..168
                     /gene="Prrg2"
                     /note="upstream in-frame stop codon"
     exon            220..373
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..885
                     /gene="Prrg2"
                     /note="transmembrane gamma-carboxyglutamic acid protein 2;
                     proline-rich Gla (G-carboxyglutamic acid) polypeptide 2;
                     proline rich Gla (G-carboxyglutamic acid) 2"
                     /codon_start=1
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     2 precursor"
                     /protein_id="NP_001425062.1"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
                     /translation="MRSHPSLLLVYMGLATCLDTLPHREQSQVLDIFLDAPEAQSFLV
                     GRRRFPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYAYNGKG
                     GRGRVDVAGLAVGLTSGILLIVLAGLGAFWYLHYRRRRLRVQESCLQETGLIIPLSPP
                     TPLSPPPPPGLPTYEQALAASGVHDAPPPPYSSLRRPH"
     sig_peptide     289..339
                     /gene="Prrg2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    385..576
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     misc_feature    385..576
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     exon            374..555
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..595
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..737
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..866
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1459
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaataact ctgcccctag ttgtggaggc gcttctcctc tcttgcaggt aatcagtagc
       61 cccgccccct gccagtagcc ggatcgggcc tagtaccaga ggtggagcac ccctcctcct
      121 tctcccctcc cctctccctt acccctttgc acagctggct actgctaacc cagagggtct
      181 tcattcaaga agagaagcag gcctcccagc cctggacaga gtctgggcag ggagtcctgg
      241 ggcctcataa ctctgctgag gcatttgtca tctgggagtt cacacaatat gaggagccat
      301 ccttccctgc tcttagtcta catgggattg gccacctgcc tggacacctt acctcataga
      361 gagcaaagcc aagttcttga catcttcctg gatgccccag aggcccagag tttcttagtt
      421 ggccgcaggc gttttcctcg tgctaaccac tgggacctgg agttgctgac ccctgggaac
      481 ctggaacggg agtgtctgga agagaggtgc tcctgggagg aggcccggga gtactttgag
      541 gacaacacac tgacggagcg tttctgggaa agctatgcat acaacggcaa gggagggcgt
      601 ggacgggtgg atgttgcagg cctggcagtg ggactgacct ctgggatcct gctcatcgtg
      661 ttggctggct tgggagcctt ttggtatctg cattatcgac ggcgccgcct cagagtccag
      721 gagtcctgtc tgcaagagac cgggctcatc atccccttaa gtcctccgac gcctctgtct
      781 ccaccgcctc ccccaggcct tcccacctat gagcaggctt tagcagcctc cggggtgcac
      841 gacgcccctc caccccctta ctccagcctc agaaggcccc actgaagacc tgctccgagc
      901 gcgggctccc tcaactgtgc ccctgattca tagcggattc cggaagtcgc cggcttcttc
      961 gacgactagg cttcagtgtg tccgtggggg agtcggggtc gtcggacccg gggtctacat
     1021 gacacacgtg tttccgccgg gcacgcatac acgcatgtcc ctgaccatcc tgttgccgag
     1081 tcggtgcccc tggcccgcgc gtgaaccccc acttctgctg agccttgcct cagaatggac
     1141 agacttttta ggaaactcgg accagacgtg actcggctgt caccccactg gtgccgcgga
     1201 gcgcgtacac tcagggaacc aggcccttac acacgcctta cttggtgtat ttccccactc
     1261 gtgcacatgg gcggttcgta atccagcata aagatggggg gcacatttgc aatgtgctgt
     1321 aagtggggtg tcaacgcttg tgttgcaccc gggtaaatgg agttgatctg agctgccctt
     1381 tacttaaaaa ccctttggga aaagggtgga agaaattaaa attgaaacaa taagaaaaat
     1441 aaaaatgcaa aagaactga
//
LOCUS       NM_001438141            1782 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 8,
            mRNA.
ACCESSION   NM_001438141
VERSION     NM_001438141.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3155.1,
                                           SRR26360181.1491763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000001.1  105127650-105127772
            124-156             JAXUCZ010000001.1  105128090-105128122
            157-208             JAXUCZ010000001.1  105128567-105128618
            209-347             JAXUCZ010000001.1  105129353-105129491
            348-485             JAXUCZ010000001.1  105130305-105130442
            486-653             JAXUCZ010000001.1  105130564-105130731
            654-826             JAXUCZ010000001.1  105131624-105131796
            827-1123            JAXUCZ010000001.1  105132438-105132734
            1124-1236           JAXUCZ010000001.1  105133588-105133700
            1237-1351           JAXUCZ010000001.1  105134128-105134242
            1352-1450           JAXUCZ010000001.1  105134333-105134431
            1451-1622           JAXUCZ010000001.1  105135522-105135693
            1623-1782           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1782
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..123
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    98..100
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            124..156
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..208
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..347
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1756
                     /gene="Tulp2"
                     /note="isoform 8 is encoded by transcript variant 8;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 8"
                     /protein_id="NP_001425070.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQA
                     HLPSGAHSALVTMSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEE
                     VTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTE
                     NSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGD
                     GDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFP
                     SYYLYLEAEDGVAHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTK
                     FTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRM
                     KVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQI
                     VHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    257..>724
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    257..>724
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    1010..1738
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    1010..1738
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            348..485
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..653
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..826
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1123
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1236
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1351
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1450
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1622
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1782
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg gcaagtgcct
       61 gtgggaattc ccttctgaga aagagtccgg ataagtttag agtttcagct tcgctgctag
      121 gccaacgtct caagagaatg aacagtggaa gaaagagacc ttggaggatg aattctctgg
      181 tgtgaggctg cagaagctgg aacaacagcg acagctattt gagaagaagc agcgccggaa
      241 acgccaggag cccctcatgg ttcaggccaa tcctgatgct tccctgaggc accggcgacc
      301 aaggcgtggg gaggagcgct tccagagtga cagcagctgg ggccttggtg ttgggagccc
      361 tttcctccag gagaacgtac cacaggcaca tctgccctca ggggcacaca gtgcccttgt
      421 caccatgagc tatgtcggag atgggagtgg tgagcgggcc cctctactgt cacccagagg
      481 agcagtatac actcggggca atgggcctgc ggtccgccat ctctgctggc tcccagacag
      541 ctccgattca gatgtggagg aagtgaccat ggaagacatt cctgtcatct cccgacctcc
      601 caagacgcac ctggcaaacc gacgcagggg ctggttagcc tccccaggac ccgggatcag
      661 tgaagaggaa gaggttgaac ccaaggatgc cagagttgaa gacaagacac ccagcccaga
      721 cccagaccct acagaaaact ctgatagagt tcatggagac tcggcatcct gcaatatgga
      781 ggaaaacaca gccaaaaaga atatagaaac agcctctggc attggggatg aagacccgga
      841 gaagaaagag gccacagagt ctacagagac aaacaatgcc ctagtggcat ccaaggtctt
      901 gcaaggagat ggtgacacca gtaaccacag tgcttggaac atgacctgcc ccatgcctcg
      961 cactccaggt cctcggctcg gggaggacat ggaagcttac gtgttgctcc ctgcaccccg
     1021 agaacacatg gtgcagtgcc gcatcgtccg aaacaagcat ggagtggaca agggcatgtt
     1081 cccttcctac tacctctacc tggaggcaga ggatggtgta gcacatttcc ttctggctgg
     1141 gcggaaaagg aaacgaagca aaacttcaaa ttacctcatc tccctggacc ccaaagacat
     1201 gtctcgcaat gggaacaact ttgtaggcaa agttagatct aatgtcttgg gcacgaaatt
     1261 caccatcttt gataatgggg tgaaccctga gcgtaactac tggattccag acagtgcccg
     1321 gatcagagag gagttgggag ttgtatgtta tgagaccaat gtcttgggat tcagggggcc
     1381 tcggaaaatg accgtgatcc tcccaggaat ggacagccgg aagcagagga tgaaagtaca
     1441 accacaaaat gatcaggatt caatactgag tcgcgtacag aaaggcgcta gacatgggct
     1501 gctcctactg cagaacaagg ccccatcgtg gagcgacgaa agcggcgcat acgtactcaa
     1561 ttttcatggt cgcgtcacgc gggcttctgt caagaacttc cagatagtgc acccggatga
     1621 accggaccac ctggtgctcc agtttggccg tgtagcacca aacatattca cgatggattt
     1681 ccgatatcct ctttgcccgc tccaagcctt cgccatctgc ttatccagtt tcgatgggaa
     1741 actggcgtgt gagtaactga ataaaatacc atccctcacc aa
//
LOCUS       NM_001438186            6640 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 2 (Man2a2),
            transcript variant 1, mRNA.
ACCESSION   NM_001438186 XM_008759527
VERSION     NM_001438186.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6640)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759527.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3867.1,
                                           SRR26360181.1866834.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               JAXUCZ010000001.1  143736479-143736867 c
            390-587             JAXUCZ010000001.1  143736112-143736309 c
            588-738             JAXUCZ010000001.1  143734935-143735085 c
            739-996             JAXUCZ010000001.1  143733704-143733961 c
            997-1141            JAXUCZ010000001.1  143733490-143733634 c
            1142-1313           JAXUCZ010000001.1  143733200-143733371 c
            1314-1441           JAXUCZ010000001.1  143732663-143732790 c
            1442-1615           JAXUCZ010000001.1  143732254-143732427 c
            1616-1802           JAXUCZ010000001.1  143731769-143731955 c
            1803-1980           JAXUCZ010000001.1  143728703-143728880 c
            1981-2183           JAXUCZ010000001.1  143728263-143728465 c
            2184-2366           JAXUCZ010000001.1  143727948-143728130 c
            2367-2481           JAXUCZ010000001.1  143727685-143727799 c
            2482-2549           JAXUCZ010000001.1  143727397-143727464 c
            2550-2715           JAXUCZ010000001.1  143727107-143727272 c
            2716-2952           JAXUCZ010000001.1  143725781-143726017 c
            2953-3075           JAXUCZ010000001.1  143724508-143724630 c
            3076-3190           JAXUCZ010000001.1  143724133-143724247 c
            3191-3324           JAXUCZ010000001.1  143723765-143723898 c
            3325-3466           JAXUCZ010000001.1  143722979-143723120 c
            3467-3603           JAXUCZ010000001.1  143721013-143721149 c
            3604-3678           JAXUCZ010000001.1  143720646-143720720 c
            3679-3873           JAXUCZ010000001.1  143718013-143718207 c
            3874-3981           JAXUCZ010000001.1  143717730-143717837 c
            3982-6640           JAXUCZ010000001.1  143713966-143716624 c
FEATURES             Location/Qualifiers
     source          1..6640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6640
                     /gene="Man2a2"
                     /note="mannosidase, alpha, class 2A, member 2"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
     exon            1..389
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..587
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    565..567
                     /gene="Man2a2"
                     /note="upstream in-frame stop codon"
     exon            588..738
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..4134
                     /gene="Man2a2"
                     /EC_number="3.2.1.114"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-mannosidase 2x; mannosidase 2, alpha 2"
                     /codon_start=1
                     /product="alpha-mannosidase 2x isoform 1"
                     /protein_id="NP_001425115.1"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPEDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLETHLRGAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNG
                     VKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVRRVDEEQEQQVDMK
                     LFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEVAAYYEHFHQVIR
                     LYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNHFRLLLERRTLMSPEPGFFSKLAAMFRGLIFSSNTIRNSKVQQERS
                     TSYPSLLSHMTSMYLNTPPLVLPVAKRESTSPTLHSFHPLASPLPCDFHLLNLRMLPA
                     EDTLPAADAALILHRKGFDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVLFLQPTSLT
                     LLYPLASPSNSTDISLEPMEISTFRLRLG"
     misc_feature    1024..4128
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     misc_feature    1024..4128
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     exon            739..996
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1141
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1313
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1441
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1615
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1802
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1980
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2183
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2366
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2481
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2549
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2715
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2952
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3075
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3190
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3324
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3466
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3603
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3678
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3873
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3981
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..6640
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtggacc ccagcgccga cccagcggga ggagaccgag ctgggtgcca gggggcgctg
       61 cggaacccgg cggggggcga ggcagcggcg gggcccggca ctaggggacg ctgcacgcag
      121 tccccccgcg cccctcctcc tgcccggcgc gccgctcgac cccgcggagg cgggagcgcg
      181 ggagcacaga cgcggggcga gcgcagggag cgcgcagcgg tcctgtcccc cgcgggagcg
      241 cggctgcagg gccgagccgg ggcggtgggt gggcaggcgt ctgtcttagc ctgcgcatct
      301 gccagcgcgc tggcggaggt ccccggggat gcgagcagtg gcggcttggc gggccgggtc
      361 cggagcgccg cggaggccgg ccgcgtacgc tccgccctct gtggcccgga cccaatctcc
      421 agggactaaa aatattgccc ggaggctcct gagcggaatc agatcgcgtt aagtaggacg
      481 caggctgagg tgacagagct tttcagcacc agggccggaa gagcagactc cagaacgcgg
      541 tcccgcccac gcgcgttcag gagctagcgt cctccctcct ccagcaggag tgtgcctggt
      601 gtcagtatga agctgaaaaa gcaggtgaca gtgtgcgggg ctgctatctt ctgtgtggcc
      661 gtcttttccc tgtacctaat gctggaccga gtgcagcatg atcctgccag acaccagaat
      721 ggtgggaact tccccaggag ccaaatttct gtgctacaga accggatcga acagctggaa
      781 cagctgctgg aagaaaacca tgagatcata agccatatca aggactctgt gctggaactg
      841 acagccaatg cggagggccc accagccctg ctgccctacc acacagccaa cggctcctgg
      901 gctgtgctcc ccgagccccg gcccagcttc ttctctgtat cccctgagga ctgccagttt
      961 gctttggggg gccggggtca gaagccagag ctacagatgt taactgtgtc tgaggatttg
     1021 ccgtttgaca atgtggaggg cggcgtgtgg aggcaaggct tcgacatctc ctacagccca
     1081 aatgactggg atgctgaaga cctgcaggtg tttgtggtgc ctcactccca caatgatcca
     1141 ggctggatca agacttttga caagtactac acggaacaaa cccaacacat cctcaacagc
     1201 atggtgtcca agctgcagga agatccccga cggcgctttc tctgggcaga agtctccttc
     1261 ttcgccaagt ggtgggacaa catcagtgcc cagaaaaggg cagcagttcg aaggctggtg
     1321 ggaaatgggc agctggaaat tgcaacgggt ggatgggtga tgccagatga ggccaactcc
     1381 cattactttg ccctggtcga ccagctcatc gagggacacc agtggctgga gagaaacctg
     1441 ggtgcaactc ctcgctcggg ctgggcagtg gacccctttg gacacagctc caccatgcct
     1501 tacctgctgc gccgtgccaa cctgaccagc atgctaattc agagggtgca ttacgccatc
     1561 aagaagcact ttgcggccac tcacagcctg gagttcatgt ggaggcagac atgggattca
     1621 gactccagca cagacatctt ctgccacatg atgcccttct acagctacga cgtcccacac
     1681 acctgtggcc ctgatcccaa gatctgctgc cagtttgatt tcaaacgtct gccgggtggg
     1741 agaatcaatt gtccttggaa ggtgccgccg cgggctatca cagaggccaa cgtggcagac
     1801 agggcagccc tgctcctgga ccagtaccgg aagaagtccc ggctgtttcg aagcagtgtc
     1861 ctccttgtgc cgctgggtga tgacttccga tatgacaagc cccaggaatg ggatgcccag
     1921 ttcttcaact atcaacggct ctttgacttc ctcaacagca agccggagtt ccacgtacag
     1981 gcacagtttg ggaccctctc tgagtatttt gatgccctgt ataagaggac aggagtggag
     2041 cctggtgccc ggcctccagg gtttcctgtg ctgagtgggg acttcttctc ctatgctgac
     2101 cgggaggacc actactggac aggctattac acttcccggc ctttctataa gagcttggac
     2161 cgcgtgctag aaactcacct tcgtggggca gaggttctat acagcctggc tttggcgcat
     2221 gcccgccgtt ctggactgac tggccagtat ccgctgtctg attacgctgt cctgacggaa
     2281 gctcgtcgta cactgggcct cttccagcac cacgatgcca tcaccggaac tgccaaggag
     2341 gcagttgtag tagactatgg ggtcaggttg ctgcgttccc tggtcagcct aaagcaggtc
     2401 atcatcaatg ctgcccacta cctggtgctg ggggacaagg agacctacag ctttgaccct
     2461 agggcaccct tcctccaaat ggatgacagt cgagtaagtc acgatgccct gcctgagcgc
     2521 acggtgatcc gtctggactc ctcacccagg tttgtggtgg tctttaaccc actggaacag
     2581 gagcggctca gtgtggtgtc cctgctggtc aactcacccc gagtgcgagt gctttcagag
     2641 gagggtcagc ccttgtctgt gcagatcagt gtgcagtgga gctccgccac caacatggtc
     2701 cccgatgtct accaggtgtc agtgcctgtc cgcctgccag ccctgggcct gggtgtgctg
     2761 cagctgcagc cagatctcga tggaccctac acactgcagt cttcggtgca tgtctacctg
     2821 aacggcgtga aactgtctgt cagcaggcaa acaacattcc ctctccgtgt tgtggactcg
     2881 ggcaccagtg acttcgccat cagcaatcga tacatgcagg tctggttctc cggccttact
     2941 gggcttctca agagcgtccg acgtgtggac gaagagcagg aacagcaggt ggacatgaag
     3001 ctcttcgtct atggaacccg cacatccaag gataagagtg gtgcctacct cttcctgcct
     3061 gataacgagg ctaagcccta tgtccctaag aaacctcctg tgctgcgcgt caccgaaggc
     3121 cctttcttct cagaggtggc tgcgtattat gagcactttc accaagtgat tcgactttac
     3181 aacctgccag gggtagaggg gctgtctctg gacgtgtcgt tccaggtgga catcagggac
     3241 tacgtgaaca aggagctagc cctgcgcatc cacacagaca tcgacagcca gggcactttc
     3301 ttcacagacc tcaatggctt tcaggtacag ccccggaagt atctgaagaa gttgcccctg
     3361 caggctaatt tctaccctat gccagtcatg gcctacatcc aggattccca gaggcgcctc
     3421 acgctgcaca ctgctcaggc tctgggtgtc tccagcctcg gcaatggcca gctggaggtg
     3481 atcttggacc gaaggctaat gcaggatgac aaccggggac taggccaagg gctcaaagac
     3541 aacaagatca cctgcaacca tttccgcctc ctgttagaac gtcgaaccct gatgagccct
     3601 gagcctggct ttttctccaa actggcagcc atgtttaggg gcttgatctt ttccagcaac
     3661 acaatcagga actcaaaggt ccaacaggag cgctctacaa gctacccgtc cctcctcagc
     3721 cacatgactt ccatgtacct caacacacct cctctggtct taccggtggc caagagggag
     3781 agcaccagcc ccactctgca ctctttccac cctctggctt ctccgttgcc ctgcgatttc
     3841 catctgctca atctgcgcat gctccccgcc gaggacacct tgcccgcggc tgatgctgct
     3901 ctcatcctac accgcaaggg ttttgactgt ggccttgaag ccaagaacct gggcttcaac
     3961 tgtaccacaa gccaaggcaa gctggccctg gggagcctct tccatggcct ggatgtgcta
     4021 ttcctgcagc ccacctcttt gactttgcta taccctctgg cctcgccctc caacagcact
     4081 gacatctctc tggagcccat ggagatcagc accttccgcc tgcgcttggg ttaggttagg
     4141 gcttcttgtg gcctgaagac gaagttcatc cacaaagact gcctcctaac accaagaccg
     4201 agttggacca gccacactga gtatcacatt ctgcctcaga actgacagac catgctctgc
     4261 ccttacgttg tctattgctg cttctgtgtt tgggccagcc cttacatcag cagacggcag
     4321 atacagtggg acagggagag gaggcccttc ccttgggttg taagtagctg cccagctggg
     4381 cacggcttag gttccatcct tttcccacaa tgggatctag gaagagcggg gacaaacaga
     4441 agaggtcagg gaggctgagg ggaacaacct cgcaccaggt gactggagtt atgaccgtgc
     4501 tctgtggggt gataggggcc ccacagtgct ggtatgaggg tacaggtgca gggtgattct
     4561 gggagatgag gggtaggtac ctgttattag tggagtaaag gcgtggagga gtccctgttt
     4621 ctcctgagag cctaaaggct ttgttgctct ctgttctggc tctgctctaa gtgctgctgg
     4681 gcctttatgc cctggctagg ggctgctggg tggcaggaag ggcttgctgg acactccagg
     4741 ccgaggccac agagcacttg aggtattcgt gccagttttc agctgctcat ttggtgttga
     4801 tttgtggcag ggtagggagt gtctccacct gacctgcttc tttatctcac acaccagtct
     4861 ccctacaagt tcccattgcc gggaccctgg cagtgttcct ttccctagaa gggaaacgga
     4921 gcttccaaga cccctatgct tgggcatctt gggaaagcaa tcccatgctg gatcccccgg
     4981 caggttcacc gtgttccatc tgcccggtgt gtggacaagg aagacagaga taaaattagg
     5041 aggcatgtgc ttcgatgagc ctccggtttt gcttcactcg atagagaatc tgtctataaa
     5101 caataagatt tggtaaaagc gaagtctcat ccttatgaaa acgtagtaag ccaagttaga
     5161 aagaagcgcc atgatctaga gaaaggtctc tgtcaccagt tactaaggca cagcgcagcc
     5221 attcccctga gagtcagaag ctggccggtg gcatgctggt acttaagggt gtcctggtgt
     5281 cactaaccca tactccagat ggagacaaga attataattg ccactgtttt aaaaccataa
     5341 gctacctaag aaacctgcgt cagccaaaga cccagcaagg ctttctatga gttgcccagt
     5401 gaagactggt tctcccaaaa tcagcccata aaaacaatgt cattcccacg agattggata
     5461 ctttttggaa ttctgcagat ttggcgttat ctggaggatg acaggctgag gatgtgaagt
     5521 agttctgaat ggcagtggtg atgtgtggcc ggtgacactg aggcggccac aggcaggtgt
     5581 cttatcagag ttctcaaagg acttggactc ttctgccagt gtgaattcag ctgccatgag
     5641 aggtcaggtc agacagacct aggcacatag aaatttagta tatgatttca agtgcagggg
     5701 agggagatga agtatttaat agtgctttga gacaactagc tatctgtgag acttctatct
     5761 cggtttcaaa aacaaaataa aaccaaaaaa ccctagggct agaggggaaa aaaaaaaaca
     5821 aaacaacaaa atcatcatca tcatcaccat cgtcatcatc atcgtcatca tcatcatcat
     5881 catcatcagc ccactatgta cctctgactg tgctggaact ctctatgtaa accacgctgg
     5941 cctggaaatc accaagatac tcacccgcct ctgcctccta aatgctggga ctaaaggctt
     6001 gtacacctgg aaagaaaaaa tatttttata cccgttgtag gaaaaaggct tttctagaca
     6061 taacgtgaaa ccgaatacat aatgggggaa agacatacac acacacacac acacaaagct
     6121 tgagagcatg ctataggaaa caggttaaat caatacaggt gcgtgggtgg gagagcatgt
     6181 gtgtgagtac cttcattgca ggagaaagtg ttttgacttc tcagagaacg gcaccagggt
     6241 ctgtccagca gtcacccaaa gattcagtag tgacagggtt gagttctttt tttttttttt
     6301 tccggagctg gggactgaac ctctactgct gagctaaatc cccagccccc agggttgagt
     6361 tctcttgcag gtcctccaga gtttttgctg ccaggctcag accacatggc ttcctattca
     6421 tgtcttggtg acagaaataa ggtgaagctt agagagcact tatcatagag tgggggttgt
     6481 ggataagctc ctcagtgtga gcataaacat ggtagaaagc ctacggaaac actcggacag
     6541 caagtgttgt ttgctggtct gtggtttgta atcaaatgat aggggacact gtgaacccct
     6601 aggaactttg cagaataaag gatattcttt ggaggtcaga
//
LOCUS       NM_001438138            1746 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 5,
            mRNA.
ACCESSION   NM_001438138 XM_063266764
VERSION     NM_001438138.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063266764.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-151              JAXUCZ010000001.1  105128551-105128618
            152-290             JAXUCZ010000001.1  105129353-105129491
            291-428             JAXUCZ010000001.1  105130305-105130442
            429-596             JAXUCZ010000001.1  105130564-105130731
            597-769             JAXUCZ010000001.1  105131624-105131796
            770-1087            JAXUCZ010000001.1  105132438-105132755
            1088-1200           JAXUCZ010000001.1  105133588-105133700
            1201-1315           JAXUCZ010000001.1  105134128-105134242
            1316-1414           JAXUCZ010000001.1  105134333-105134431
            1415-1586           JAXUCZ010000001.1  105135522-105135693
            1587-1746           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1746
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1720
                     /gene="Tulp2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 5"
                     /protein_id="NP_001425067.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MNSGRKTCVSLRTLEDEFSGVRLQKLEQQRQLFEKKQRRKRQEP
                     LMVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQAHLPSGAHSALVTM
                     SYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVTMEDIPVISRPP
                     KTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENSDRVHGDSASCN
                     MEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGDTSNHSAWNMTC
                     PMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSYYLYLEAEDGVA
                     VRSSPLGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTKFTIFDN
                     GVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQN
                     DQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEP
                     DHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    146..>667
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    146..>667
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    953..1702
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    953..1702
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            84..151
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..290
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..428
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..596
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..769
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1087
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1200
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1315
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1414
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1586
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1746
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agacttgtgt ttctctcagg accttggagg atgaattctc
      121 tggtgtgagg ctgcagaagc tggaacaaca gcgacagcta tttgagaaga agcagcgccg
      181 gaaacgccag gagcccctca tggttcaggc caatcctgat gcttccctga ggcaccggcg
      241 accaaggcgt ggggaggagc gcttccagag tgacagcagc tggggccttg gtgttgggag
      301 ccctttcctc caggagaacg taccacaggc acatctgccc tcaggggcac acagtgccct
      361 tgtcaccatg agctatgtcg gagatgggag tggtgagcgg gcccctctac tgtcacccag
      421 aggagcagta tacactcggg gcaatgggcc tgcggtccgc catctctgct ggctcccaga
      481 cagctccgat tcagatgtgg aggaagtgac catggaagac attcctgtca tctcccgacc
      541 tcccaagacg cacctggcaa accgacgcag gggctggtta gcctccccag gacccgggat
      601 cagtgaagag gaagaggttg aacccaagga tgccagagtt gaagacaaga cacccagccc
      661 agacccagac cctacagaaa actctgatag agttcatgga gactcggcat cctgcaatat
      721 ggaggaaaac acagccaaaa agaatataga aacagcctct ggcattgggg atgaagaccc
      781 ggagaagaaa gaggccacag agtctacaga gacaaacaat gccctagtgg catccaaggt
      841 cttgcaagga gatggtgaca ccagtaacca cagtgcttgg aacatgacct gccccatgcc
      901 tcgcactcca ggtcctcggc tcggggagga catggaagct tacgtgttgc tccctgcacc
      961 ccgagaacac atggtgcagt gccgcatcgt ccgaaacaag catggagtgg acaagggcat
     1021 gttcccttcc tactacctct acctggaggc agaggatggt gtagcagtac gctccagccc
     1081 tttggggcat ttccttctgg ctgggcggaa aaggaaacga agcaaaactt caaattacct
     1141 catctccctg gaccccaaag acatgtctcg caatgggaac aactttgtag gcaaagttag
     1201 atctaatgtc ttgggcacga aattcaccat ctttgataat ggggtgaacc ctgagcgtaa
     1261 ctactggatt ccagacagtg cccggatcag agaggagttg ggagttgtat gttatgagac
     1321 caatgtcttg ggattcaggg ggcctcggaa aatgaccgtg atcctcccag gaatggacag
     1381 ccggaagcag aggatgaaag tacaaccaca aaatgatcag gattcaatac tgagtcgcgt
     1441 acagaaaggc gctagacatg ggctgctcct actgcagaac aaggccccat cgtggagcga
     1501 cgaaagcggc gcatacgtac tcaattttca tggtcgcgtc acgcgggctt ctgtcaagaa
     1561 cttccagata gtgcacccgg atgaaccgga ccacctggtg ctccagtttg gccgtgtagc
     1621 accaaacata ttcacgatgg atttccgata tcctctttgc ccgctccaag ccttcgccat
     1681 ctgcttatcc agtttcgatg ggaaactggc gtgtgagtaa ctgaataaaa taccatccct
     1741 caccaa
//
LOCUS       NM_001438139            1725 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 6,
            mRNA.
ACCESSION   NM_001438139 XM_063266786
VERSION     NM_001438139.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063266786.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3157.1,
                                           SRR26360181.498551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-151              JAXUCZ010000001.1  105128551-105128618
            152-290             JAXUCZ010000001.1  105129353-105129491
            291-428             JAXUCZ010000001.1  105130305-105130442
            429-596             JAXUCZ010000001.1  105130564-105130731
            597-769             JAXUCZ010000001.1  105131624-105131796
            770-1066            JAXUCZ010000001.1  105132438-105132734
            1067-1179           JAXUCZ010000001.1  105133588-105133700
            1180-1294           JAXUCZ010000001.1  105134128-105134242
            1295-1393           JAXUCZ010000001.1  105134333-105134431
            1394-1565           JAXUCZ010000001.1  105135522-105135693
            1566-1725           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1725
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1699
                     /gene="Tulp2"
                     /note="isoform 6 is encoded by transcript variant 6;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 6"
                     /protein_id="NP_001425068.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MNSGRKTCVSLRTLEDEFSGVRLQKLEQQRQLFEKKQRRKRQEP
                     LMVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQAHLPSGAHSALVTM
                     SYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVTMEDIPVISRPP
                     KTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENSDRVHGDSASCN
                     MEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGDTSNHSAWNMTC
                     PMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSYYLYLEAEDGVA
                     HFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTKFTIFDNGVNPERN
                     YWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDQDSILS
                     RVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQF
                     GRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    146..>667
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    146..>667
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    953..1681
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    953..1681
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            84..151
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..290
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..428
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..596
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..769
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1066
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1179
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1294
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1393
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1565
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1725
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agacttgtgt ttctctcagg accttggagg atgaattctc
      121 tggtgtgagg ctgcagaagc tggaacaaca gcgacagcta tttgagaaga agcagcgccg
      181 gaaacgccag gagcccctca tggttcaggc caatcctgat gcttccctga ggcaccggcg
      241 accaaggcgt ggggaggagc gcttccagag tgacagcagc tggggccttg gtgttgggag
      301 ccctttcctc caggagaacg taccacaggc acatctgccc tcaggggcac acagtgccct
      361 tgtcaccatg agctatgtcg gagatgggag tggtgagcgg gcccctctac tgtcacccag
      421 aggagcagta tacactcggg gcaatgggcc tgcggtccgc catctctgct ggctcccaga
      481 cagctccgat tcagatgtgg aggaagtgac catggaagac attcctgtca tctcccgacc
      541 tcccaagacg cacctggcaa accgacgcag gggctggtta gcctccccag gacccgggat
      601 cagtgaagag gaagaggttg aacccaagga tgccagagtt gaagacaaga cacccagccc
      661 agacccagac cctacagaaa actctgatag agttcatgga gactcggcat cctgcaatat
      721 ggaggaaaac acagccaaaa agaatataga aacagcctct ggcattgggg atgaagaccc
      781 ggagaagaaa gaggccacag agtctacaga gacaaacaat gccctagtgg catccaaggt
      841 cttgcaagga gatggtgaca ccagtaacca cagtgcttgg aacatgacct gccccatgcc
      901 tcgcactcca ggtcctcggc tcggggagga catggaagct tacgtgttgc tccctgcacc
      961 ccgagaacac atggtgcagt gccgcatcgt ccgaaacaag catggagtgg acaagggcat
     1021 gttcccttcc tactacctct acctggaggc agaggatggt gtagcacatt tccttctggc
     1081 tgggcggaaa aggaaacgaa gcaaaacttc aaattacctc atctccctgg accccaaaga
     1141 catgtctcgc aatgggaaca actttgtagg caaagttaga tctaatgtct tgggcacgaa
     1201 attcaccatc tttgataatg gggtgaaccc tgagcgtaac tactggattc cagacagtgc
     1261 ccggatcaga gaggagttgg gagttgtatg ttatgagacc aatgtcttgg gattcagggg
     1321 gcctcggaaa atgaccgtga tcctcccagg aatggacagc cggaagcaga ggatgaaagt
     1381 acaaccacaa aatgatcagg attcaatact gagtcgcgta cagaaaggcg ctagacatgg
     1441 gctgctccta ctgcagaaca aggccccatc gtggagcgac gaaagcggcg catacgtact
     1501 caattttcat ggtcgcgtca cgcgggcttc tgtcaagaac ttccagatag tgcacccgga
     1561 tgaaccggac cacctggtgc tccagtttgg ccgtgtagca ccaaacatat tcacgatgga
     1621 tttccgatat cctctttgcc cgctccaagc cttcgccatc tgcttatcca gtttcgatgg
     1681 gaaactggcg tgtgagtaac tgaataaaat accatccctc accaa
//
LOCUS       NM_001438217            2098 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 4, mRNA.
ACCESSION   NM_001438217
VERSION     NM_001438217.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.647744.1,
                                           SRR26360181.2991802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000001.1  191919776-191919832 c
            58-726              JAXUCZ010000001.1  191907790-191908458 c
            727-2098            JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2098
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..57
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     exon            58..726
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1939
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425146.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    149..211
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    149..211
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    272..1336
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    272..1336
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    335..397
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    335..397
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    419..481
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    419..481
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    503..565
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    503..565
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    587..649
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    587..649
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    671..733
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    671..733
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    755..817
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    755..817
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(770..772,776..778,782..784,788..793,800..805,
                     812..814,854..856,860..862,872..877,884..889,896..898,
                     938..940,944..946,950..952,956..961,968..973,980..982)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(770..772,776..778,782..784,788..793,800..805,
                     812..814,854..856,860..862,872..877,884..889,896..898,
                     938..940,944..946,950..952,956..961,968..973,980..982)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    821..1873
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    821..1873
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    839..901
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    839..901
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    923..985
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    923..985
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1007..1069
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1007..1069
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1091..1153
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1091..1153
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1175..1237
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1175..1237
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1259..1321
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1259..1321
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1631..1693
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1631..1693
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1646..1648,1652..1654,1658..1660,1664..1669,
                     1676..1681,1688..1690,1730..1732,1736..1738,1748..1753,
                     1760..1765,1772..1774,1814..1816,1820..1822,1826..1828,
                     1832..1837,1844..1849,1856..1858)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1646..1648,1652..1654,1658..1660,1664..1669,
                     1676..1681,1688..1690,1730..1732,1736..1738,1748..1753,
                     1760..1765,1772..1774,1814..1816,1820..1822,1826..1828,
                     1832..1837,1844..1849,1856..1858)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1715..1777
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1715..1777
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1799..1861
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1799..1861
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            727..2098
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagccatg gtatggaaat gcttggtaca ggtcccacaa ctgaagtctc ctgtctgaga
       61 aggtctactc accgaggcca tggaagtgga ggctgcagag gccaagtccc caggcccctg
      121 ctacaagcgc tctggccgcc gttataagtg cctgttttgt acaaagacat ttccaaatgc
      181 tcccagggca gcccgccatg ctgctacaca tacaactaca gactgcacag aggaggtgaa
      241 tgaggtccag ccgaaggtgg atgcagagcc caaggctgag gaagccagtg gagacaaggt
      301 atctgggtca gtagccaagc cccggcccta tgcttgccct ctgtgcccca aggcctacaa
      361 gacagctcct gagctacgca gccatggacg cagccacact ggtgagaagc ccttcccgtg
      421 cccagagtgc ggccgccgtt tcatgcagcc agtgtgcctg cgtgtgcacc tggcctcaca
      481 cgctggtgag ctgcctttcc gatgcacaca ctgccccaag gcttatggta cactctctaa
      541 actaaagatc caccagcgtg ggcacacagg cgagcggccc tatgcctgta ctgactgcgg
      601 caagagcttt gctgatcctt cagtgttccg caagcatcgg cgcacgcatg caggcctgcg
      661 cccctacagc tgcgagcgct gcggcaaggc ctatgctgag ctgaaggact tacgcaacca
      721 cgaaaggtcc cacacgggtg agcgcccctt cctctgctca gagtgtggta aaagcttctc
      781 tcgatcctct tccctcacat gccatcagcg tatccatgca gcccagaaac cctatcgctg
      841 cccggcttgt ggtaagggct tcacacagct cagctcttac caaagccatg agcgcacaca
      901 ttcaggcgaa aagcccttcc tgtgccctcg gtgtggccgc atgttctctg atccctcgag
      961 cttccgccgc caccagcggg cacatgaggg tgtaaagcct taccgctgtg agaaatgtgg
     1021 caaggacttc cggcagccag ctgacctggc catgcaccgt cgagtacaca ccggcgaccg
     1081 acccttcaag tgcctgcagt gtgacaagac ttttgtggct tcctgggacc tcaagcggca
     1141 tgcattggta cactcaggac agcggccgtt ccgctgtgag gagtgtgggc gagcatttgc
     1201 tgagcgagct agccttacaa agcacagccg catgcactct ggcgagcgtc ctttccactg
     1261 taatgcctgc gggaaatcct ttgtggtgtt atccagcctc aggaagcatg agcgcaccca
     1321 tagaagcaac gagactacgg gagctgcccc ccagcaggag ttggtactgg gactagcact
     1381 gcctgtaggt gtcgtaggtg agggctcagc tgcccctgtg gcaggtgcag ggatagggga
     1441 tgctccagca gggctgctag ggttaccgcc tgagtctggt agtgtagtgg ccacacagtg
     1501 gcaagtggtg ggcatgactg tagagcatgt ggagtgccag gatgctggcg ttggcgaagc
     1561 tcctagtacc ctgggagatg caggagaggt gggtggggag gagactgatg agaagccccc
     1621 acagtttgtg tgtcgagagt gcaaagaaac tttctccaca ctgacattgc tacgcaggca
     1681 tgaacgctca cacccagagc tccggccctt tccctgcacc cagtgtggta agagcttctc
     1741 agacagggct gggcttcgta agcatagccg cacccacagc tctgtacgcc cctactcctg
     1801 ttcccaatgt cctaaagctt tcctgagtgc cagtgatctg cgcaaacatg aacgcaccca
     1861 ccctgtgccc atcgggaccc ccatacccct ggaacccctt gtggctctgc taggaatgcc
     1921 agaagaaggg tcagcctgaa gtttatagat ctccactaca ctcccagaag gccatcccta
     1981 gtctccaaac ccctgcctct gggcagctag ctcagttctc gtccactaag agctgtggac
     2041 agtggaagct ggtagcattt gtgagaggta ctcattaaag cattggcttt gataccaa
//
LOCUS       NM_001009965            2570 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 1, mRNA.
ACCESSION   NM_001009965 XM_218945
VERSION     NM_001009965.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced NM_001009965.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100644.1, SRR26643294.3232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000001.1  162082635-162082764 c
            131-2570            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2570
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..130
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    13..15
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            131..2570
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1200
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001009965.2"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     139..189
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     190..1197
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    316..378
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    325..396
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    325..396
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    361..363
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <391..>1056
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <391..>1056
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    394..459
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    406..468
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    406..468
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    466..531
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    469..537
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    469..537
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    535..600
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    538..615
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    538..615
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    550..552
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    616..696
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    616..696
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    616..678
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    694..759
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    697..753
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    697..753
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    709..711
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    760..831
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    760..831
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    760..822
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    829..897
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    832..906
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    832..906
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    904..969
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    907..981
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    907..981
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    979..1044
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    982..1053
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    982..1053
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtg ggtgctgtcc
       61 cgaagcgcag cgagatcggc gccggtttgg aggtttggag cccgggactt caacctcacc
      121 gccccatcct gtgtcaccat gttgtgcacc ctgttcctgc tactgctggc cctgggcaca
      181 gtgcagacaa ctcggccatg tttccctggc tgccagtgtg aggaagagac gtttggcctc
      241 tttgacagtt tcagcctgat ccgagtggac tgcagcagcc tgggccccca cattgtgcct
      301 gtgcccatcc ctctggacac agcccacctg gacctgtctt ccaaccggct agaaaccgtg
      361 aatgagtcag tcctgggagg gccaggctat accacactgg ctggcctgga tctcagtcac
      421 aacctcctca ccagcatcac gcccactgcc ttctcccgcc ttcgctacct ggagtcactg
      481 gacctcagtc acaatggcct ggcagccctg ccagcagagg ttttcaccag ctcccccttg
      541 agtgatatca acctgagcca taatcgactt agagaggtct caatatctgc cttcaccacc
      601 cacagccagg ggcgggcact gcacgtggac ctatcccaca atcttatcca ccgcctgctc
      661 ccctatccag ccagggccag cctgtccgca cctaccattc agagcctgaa cctgtcctgg
      721 aaccggctcc gagccgtgcc caatctccga gacctacccc tgcgttacct gagcctggat
      781 gggaaccctc tggctaccat caacccaggc gccttcatgg ggctggcggg cctcacccac
      841 ctttcactgg caagcctaca gggtatcctc cagctaccac cccatggctt ccgagagctc
      901 ccaggccttc aggtcctgga cttgtctggt aaccccaagc tcaagtgggc aggagccgag
      961 gtattttcag gcctgggttt gctgcaagaa ctagacctgt ctggctccag cctggtgccc
     1021 ctgcctgaga cgctgctaca tcacctccct gctttacaga gtgtcagtgt aggccaagat
     1081 gtgcagtgcc ggcgtctggt acgggagggt gcctaccacc gccaacccgg ttccagccct
     1141 aaggtagtcc tgcactgtgg agacacccag gaatctgcca ggggcccaga catcttgtga
     1201 cgaatggtgt ggcctgaggc cacttgacag actgctgtcc tgggcttgct caggtcccca
     1261 ctaatatttt aatgtgccaa tgcctgtgga gtgtctacag gtctaagtgg cagccatctc
     1321 agtgaagatg tgggccaagg atagttttca tacctagggc ctatacccaa taacagaatc
     1381 tgcccgcttg tctcagcggc tcacttccct gagctatgag caaagggact tcgatgccaa
     1441 accagacttt ggtcccttcc tgagccctgc cccagttatc tctaagtgcc ttcccttttg
     1501 cccagactga cctgacccat gatgtaagga ccgtagggga gcaccaccac tgcaaaggct
     1561 gactaaggtc tgttgggcta aaggtctctt tgagcccagt gtctatagtc acaccttctt
     1621 tgctctgggc ccaggaggcc tacttcttct ttttctcgtg gaatcctgga atcttaaaga
     1681 taaaagaacc tagaaagaaa atcaaaccca ttttccttgt ggggcagatg gtaatatggg
     1741 actgagaaca gcaaacctgg ggtcttggag aggagcccag cctcctgttg aggttgagag
     1801 ctctgtcacc ctcccttccc ctgctgggta ccctgttact attgtctgta ctgttttcca
     1861 ttgtgcccag cagtagcaac aacaaggtca cagaggtggg aactctaggt ccagtggcca
     1921 gcttatggtg tgagcgtagt cagtccccct ttcagagcct caggaagctt ggagcacctc
     1981 agtctcaagc ctgtcagttc cttactctgg gatgaccccc aacatcaaga ctggaaacat
     2041 acacattctc cccagggaca cagtcttaag atgcttttct aagaagtcaa tgcagttgtg
     2101 accatgtggc catgagctcc aagggactcg tgggcttggt gtccatgggc cggagcccaa
     2161 agacccgctt ccccctccaa gagtatggca gaaagggtct cccatgcaca ttgtgctccc
     2221 cgccagggcc acatctcagc tctccagctc tggattcttt cttctgtttt cattttatga
     2281 gtcgttgtct tttttaaaat gaactgttta acccccacct ctgctggcca ggggatggaa
     2341 aggaagataa atgtatttgt tcgcttttgt aagactctgt tctgggtgtg ggctggggat
     2401 cttgggaaga agccagttgg ctatcagtaa ccatgtgggc attggggctg gtccctggga
     2461 tgctcaaaag tcagtgagag ctctgtcttc tcacactagc ccagcccagc ccaccccgtg
     2521 actggtcctt ggtttaataa acacatgtaa gagctctttc catcactgga
//
LOCUS       NM_001438197            2847 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 7, mRNA.
ACCESSION   NM_001438197 XM_063262800
VERSION     NM_001438197.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2847)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2847)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2847)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2847)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063262800.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1125364.1,
                                           SRR21887620.1723369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840116
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000001.1  162082444-162082571 c
            129-407             JAXUCZ010000001.1  162081503-162081781 c
            408-2847            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2847
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..128
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     exon            129..407
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    299..301
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            408..2847
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1477
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425126.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     416..466
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     467..1474
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    593..655
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    602..673
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    602..673
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    638..640
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <668..>1333
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <668..>1333
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    671..736
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    683..745
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    683..745
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    743..808
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    746..814
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    746..814
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    812..877
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    815..892
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    815..892
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    827..829
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    893..973
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    893..973
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    893..955
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    971..1036
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    974..1030
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    974..1030
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    986..988
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    1037..1108
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1037..1108
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1037..1099
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    1106..1174
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    1109..1183
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1109..1183
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1181..1246
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    1184..1258
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1184..1258
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1256..1321
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    1259..1330
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1259..1330
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 acggagccac agcggcgcag ggtccgggga gcaggggtga gggctttcag aagacaaagg
       61 ctctgcttgg gggccgtggg cgtgggccgg cgcctccagg gtctttgtaa gaacacgtgc
      121 atctcacggt tagaaaggcc acggtttgcc tgcatccggc ctgcttgtgg cccctgtccc
      181 tggttgggct gtgatgagaa gaggccttcc acacactagt ttcgaaaggc acgccaatgg
      241 cccacgtagg atacgggcgt gtggctgaaa cccgttgaga ttcggtcact gttgtggatg
      301 aagtgagaag aactctatcc ctcgggagcg gagcgcacaa gtggtggtga ccagcgtggc
      361 gagcttagct gaaagcggct cccgcccaca cttggccggg cccagaggtg tcaccatgtt
      421 gtgcaccctg ttcctgctac tgctggccct gggcacagtg cagacaactc ggccatgttt
      481 ccctggctgc cagtgtgagg aagagacgtt tggcctcttt gacagtttca gcctgatccg
      541 agtggactgc agcagcctgg gcccccacat tgtgcctgtg cccatccctc tggacacagc
      601 ccacctggac ctgtcttcca accggctaga aaccgtgaat gagtcagtcc tgggagggcc
      661 aggctatacc acactggctg gcctggatct cagtcacaac ctcctcacca gcatcacgcc
      721 cactgccttc tcccgccttc gctacctgga gtcactggac ctcagtcaca atggcctggc
      781 agccctgcca gcagaggttt tcaccagctc ccccttgagt gatatcaacc tgagccataa
      841 tcgacttaga gaggtctcaa tatctgcctt caccacccac agccaggggc gggcactgca
      901 cgtggaccta tcccacaatc ttatccaccg cctgctcccc tatccagcca gggccagcct
      961 gtccgcacct accattcaga gcctgaacct gtcctggaac cggctccgag ccgtgcccaa
     1021 tctccgagac ctacccctgc gttacctgag cctggatggg aaccctctgg ctaccatcaa
     1081 cccaggcgcc ttcatggggc tggcgggcct cacccacctt tcactggcaa gcctacaggg
     1141 tatcctccag ctaccacccc atggcttccg agagctccca ggccttcagg tcctggactt
     1201 gtctggtaac cccaagctca agtgggcagg agccgaggta ttttcaggcc tgggtttgct
     1261 gcaagaacta gacctgtctg gctccagcct ggtgcccctg cctgagacgc tgctacatca
     1321 cctccctgct ttacagagtg tcagtgtagg ccaagatgtg cagtgccggc gtctggtacg
     1381 ggagggtgcc taccaccgcc aacccggttc cagccctaag gtagtcctgc actgtggaga
     1441 cacccaggaa tctgccaggg gcccagacat cttgtgacga atggtgtggc ctgaggccac
     1501 ttgacagact gctgtcctgg gcttgctcag gtccccacta atattttaat gtgccaatgc
     1561 ctgtggagtg tctacaggtc taagtggcag ccatctcagt gaagatgtgg gccaaggata
     1621 gttttcatac ctagggccta tacccaataa cagaatctgc ccgcttgtct cagcggctca
     1681 cttccctgag ctatgagcaa agggacttcg atgccaaacc agactttggt cccttcctga
     1741 gccctgcccc agttatctct aagtgccttc ccttttgccc agactgacct gacccatgat
     1801 gtaaggaccg taggggagca ccaccactgc aaaggctgac taaggtctgt tgggctaaag
     1861 gtctctttga gcccagtgtc tatagtcaca ccttctttgc tctgggccca ggaggcctac
     1921 ttcttctttt tctcgtggaa tcctggaatc ttaaagataa aagaacctag aaagaaaatc
     1981 aaacccattt tccttgtggg gcagatggta atatgggact gagaacagca aacctggggt
     2041 cttggagagg agcccagcct cctgttgagg ttgagagctc tgtcaccctc ccttcccctg
     2101 ctgggtaccc tgttactatt gtctgtactg ttttccattg tgcccagcag tagcaacaac
     2161 aaggtcacag aggtgggaac tctaggtcca gtggccagct tatggtgtga gcgtagtcag
     2221 tccccctttc agagcctcag gaagcttgga gcacctcagt ctcaagcctg tcagttcctt
     2281 actctgggat gacccccaac atcaagactg gaaacataca cattctcccc agggacacag
     2341 tcttaagatg cttttctaag aagtcaatgc agttgtgacc atgtggccat gagctccaag
     2401 ggactcgtgg gcttggtgtc catgggccgg agcccaaaga cccgcttccc cctccaagag
     2461 tatggcagaa agggtctccc atgcacattg tgctccccgc cagggccaca tctcagctct
     2521 ccagctctgg attctttctt ctgttttcat tttatgagtc gttgtctttt ttaaaatgaa
     2581 ctgtttaacc cccacctctg ctggccaggg gatggaaagg aagataaatg tatttgttcg
     2641 cttttgtaag actctgttct gggtgtgggc tggggatctt gggaagaagc cagttggcta
     2701 tcagtaacca tgtgggcatt ggggctggtc cctgggatgc tcaaaagtca gtgagagctc
     2761 tgtcttctca cactagccca gcccagccca ccccgtgact ggtccttggt ttaataaaca
     2821 catgtaagag ctctttccat cactgga
//
LOCUS       NM_001438196            3702 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 6, mRNA.
ACCESSION   NM_001438196
VERSION     NM_001438196.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1152350.1,
                                           SRR26643288.3317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1262              JAXUCZ010000001.1  162081503-162082764 c
            1263-3702           JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3702
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..1262
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1154..1156
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            1263..3702
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             1271..2332
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425125.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     1271..1321
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     1322..2329
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    1448..1510
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    1457..1528
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1457..1528
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1493..1495
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <1523..>2188
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <1523..>2188
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1526..1591
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    1538..1600
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1538..1600
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1598..1663
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    1601..1669
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1601..1669
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1667..1732
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    1670..1747
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1670..1747
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1682..1684
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    1748..1828
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1748..1828
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1748..1810
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    1826..1891
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    1829..1885
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1829..1885
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1841..1843
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    1892..1963
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1892..1963
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1892..1954
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    1961..2029
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    1964..2038
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1964..2038
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2036..2101
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    2039..2113
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2039..2113
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2111..2176
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    2114..2185
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2114..2185
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtg ggtgctgtcc
       61 cgaagcgcag cgagatcggc gccggtttgg aggtttggag cccgggactt caacctcacc
      121 gccccatcct gtgagcaggc cggtgcgagg ggcgggtccg ggtcctgctg aggcccctca
      181 acttttccgg gacacggagc cacagcggcg cagggtccgg ggagcagggg tgagggcttt
      241 cagaagacaa aggctctgct tgggggccgt gggcgtgggc cggcgcctcc agggtctttg
      301 taagaacacg tgcatctcac ggtagtgggt cttttgtaga tttgggttcg gaagctagca
      361 tctgcctgtg cctttgtgtg tgcgtggctt tgcatggcta tctcgccccg gtgtccccgt
      421 tttgtagcct tgcgtttggt tgtggggacc ggtgggcgct cctagtgtcc gcatacgtgg
      481 tctaggcttg tcgacgtgtc tgggttgagt atccgtgggg tatgtgcgaa ctgagagcct
      541 gaagctgccc agactctgtt cccctgctgt ccttcgtttt ccccctactt ggcttcaaac
      601 ttttctctgg gttcctccgg caacgcctgt tggcagccct tctgtctctc acctccggag
      661 gtcctttgag ccgcgggatg gattcggtgg gttgggggtg gtcagcagtg cctagcgact
      721 ggccccggcc aggactgggc ggagtgtgca ggacaccctt acaggacccc agtgggaggg
      781 ggaggggaca ccgcttgtct gggctctggc ctgaggctgg agaccccgga gtagcgcaat
      841 gctggcagta gtcttctctg cgcccctggg acagagtgtg gatggagata tgtctgcttg
      901 gtggagagac atgattggct ttgagttcca ctctgcattt aaccggaccc cagtgtgagg
      961 ggacgaacct tccgatcctg taggttagaa aggccacggt ttgcctgcat ccggcctgct
     1021 tgtggcccct gtccctggtt gggctgtgat gagaagaggc cttccacaca ctagtttcga
     1081 aaggcacgcc aatggcccac gtaggatacg ggcgtgtggc tgaaacccgt tgagattcgg
     1141 tcactgttgt ggatgaagtg agaagaactc tatccctcgg gagcggagcg cacaagtggt
     1201 ggtgaccagc gtggcgagct tagctgaaag cggctcccgc ccacacttgg ccgggcccag
     1261 aggtgtcacc atgttgtgca ccctgttcct gctactgctg gccctgggca cagtgcagac
     1321 aactcggcca tgtttccctg gctgccagtg tgaggaagag acgtttggcc tctttgacag
     1381 tttcagcctg atccgagtgg actgcagcag cctgggcccc cacattgtgc ctgtgcccat
     1441 ccctctggac acagcccacc tggacctgtc ttccaaccgg ctagaaaccg tgaatgagtc
     1501 agtcctggga gggccaggct ataccacact ggctggcctg gatctcagtc acaacctcct
     1561 caccagcatc acgcccactg ccttctcccg ccttcgctac ctggagtcac tggacctcag
     1621 tcacaatggc ctggcagccc tgccagcaga ggttttcacc agctccccct tgagtgatat
     1681 caacctgagc cataatcgac ttagagaggt ctcaatatct gccttcacca cccacagcca
     1741 ggggcgggca ctgcacgtgg acctatccca caatcttatc caccgcctgc tcccctatcc
     1801 agccagggcc agcctgtccg cacctaccat tcagagcctg aacctgtcct ggaaccggct
     1861 ccgagccgtg cccaatctcc gagacctacc cctgcgttac ctgagcctgg atgggaaccc
     1921 tctggctacc atcaacccag gcgccttcat ggggctggcg ggcctcaccc acctttcact
     1981 ggcaagccta cagggtatcc tccagctacc accccatggc ttccgagagc tcccaggcct
     2041 tcaggtcctg gacttgtctg gtaaccccaa gctcaagtgg gcaggagccg aggtattttc
     2101 aggcctgggt ttgctgcaag aactagacct gtctggctcc agcctggtgc ccctgcctga
     2161 gacgctgcta catcacctcc ctgctttaca gagtgtcagt gtaggccaag atgtgcagtg
     2221 ccggcgtctg gtacgggagg gtgcctacca ccgccaaccc ggttccagcc ctaaggtagt
     2281 cctgcactgt ggagacaccc aggaatctgc caggggccca gacatcttgt gacgaatggt
     2341 gtggcctgag gccacttgac agactgctgt cctgggcttg ctcaggtccc cactaatatt
     2401 ttaatgtgcc aatgcctgtg gagtgtctac aggtctaagt ggcagccatc tcagtgaaga
     2461 tgtgggccaa ggatagtttt catacctagg gcctataccc aataacagaa tctgcccgct
     2521 tgtctcagcg gctcacttcc ctgagctatg agcaaaggga cttcgatgcc aaaccagact
     2581 ttggtccctt cctgagccct gccccagtta tctctaagtg ccttcccttt tgcccagact
     2641 gacctgaccc atgatgtaag gaccgtaggg gagcaccacc actgcaaagg ctgactaagg
     2701 tctgttgggc taaaggtctc tttgagccca gtgtctatag tcacaccttc tttgctctgg
     2761 gcccaggagg cctacttctt ctttttctcg tggaatcctg gaatcttaaa gataaaagaa
     2821 cctagaaaga aaatcaaacc cattttcctt gtggggcaga tggtaatatg ggactgagaa
     2881 cagcaaacct ggggtcttgg agaggagccc agcctcctgt tgaggttgag agctctgtca
     2941 ccctcccttc ccctgctggg taccctgtta ctattgtctg tactgttttc cattgtgccc
     3001 agcagtagca acaacaaggt cacagaggtg ggaactctag gtccagtggc cagcttatgg
     3061 tgtgagcgta gtcagtcccc ctttcagagc ctcaggaagc ttggagcacc tcagtctcaa
     3121 gcctgtcagt tccttactct gggatgaccc ccaacatcaa gactggaaac atacacattc
     3181 tccccaggga cacagtctta agatgctttt ctaagaagtc aatgcagttg tgaccatgtg
     3241 gccatgagct ccaagggact cgtgggcttg gtgtccatgg gccggagccc aaagacccgc
     3301 ttccccctcc aagagtatgg cagaaagggt ctcccatgca cattgtgctc cccgccaggg
     3361 ccacatctca gctctccagc tctggattct ttcttctgtt ttcattttat gagtcgttgt
     3421 cttttttaaa atgaactgtt taacccccac ctctgctggc caggggatgg aaaggaagat
     3481 aaatgtattt gttcgctttt gtaagactct gttctgggtg tgggctgggg atcttgggaa
     3541 gaagccagtt ggctatcagt aaccatgtgg gcattggggc tggtccctgg gatgctcaaa
     3601 agtcagtgag agctctgtct tctcacacta gcccagccca gcccaccccg tgactggtcc
     3661 ttggtttaat aaacacatgt aagagctctt tccatcactg ga
//
LOCUS       NM_001438163             712 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus adipogenesis associated, Mth938 domain containing
            (Aamdc), transcript variant 2, mRNA.
ACCESSION   NM_001438163 XM_006229768
VERSION     NM_001438163.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 712)
  AUTHORS   Ma,X., Ding,W., Wang,J., Wu,G., Zhang,H., Yin,J., Zhou,L. and Li,D.
  TITLE     LOC66273 isoform 2, a novel protein highly expressed in white
            adipose tissue, induces adipogenesis in 3T3-L1 cells
  JOURNAL   J Nutr 142 (3), 448-455 (2012)
   PUBMED   22279136
REFERENCE   2  (bases 1 to 712)
  AUTHORS   Wang,H., Ma,X., Zhang,H., Zang,J., Hu,S. and Li,D.
  TITLE     Involvement of LOC66273 isoform 2, a novel Mth938 containing
            protein, in MAPK pathway
  JOURNAL   Front Biosci (Elite Ed) 3 (4), 1241-1248 (2011)
   PUBMED   21622130
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229768.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CV797630.1, BI289587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840121, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  161303116-161303192 c
            78-227              JAXUCZ010000001.1  161287359-161287508 c
            228-323             JAXUCZ010000001.1  161281014-161281109 c
            324-712             JAXUCZ010000001.1  161273216-161273604 c
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..712
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="adipogenesis associated, Mth938 domain containing"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     exon            1..77
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    30..32
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="upstream in-frame stop codon"
     exon            78..227
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..464
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /codon_start=1
                     /product="mth938 domain-containing protein"
                     /protein_id="NP_001425092.1"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
                     /translation="MLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETG
                     TEHSPGVQPADVKEVAEKGVQTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQA
                     VKEYNALAARGIRVGGVFHSTC"
     misc_feature    108..455
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="Mth938 domain. Mth938 is a hypothetical protein
                     encoded by the Methanobacterium thermoautotrophicum (Mth)
                     genome. This protein crystallizes as a dimer, although it
                     is monomeric in solution, with one disulfide bond in each
                     monomer. The function of the...; Region: Mth938; cd05126"
                     /db_xref="CDD:240162"
     misc_feature    108..455
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="Mth938 domain. Mth938 is a hypothetical protein
                     encoded by the Methanobacterium thermoautotrophicum (Mth)
                     genome. This protein crystallizes as a dimer, although it
                     is monomeric in solution, with one disulfide bond in each
                     monomer. The function of the...; Region: Mth938; cd05126"
                     /db_xref="CDD:240162"
     exon            228..323
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            324..712
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatctctc agctagctgc agggagaggt agagcgcgga gccgactgga ggagcaaccg
       61 aagaacagaa gcgctgcatt tcagttcaca tgcttatggc ttcccctaaa attgcttccc
      121 tctcttgggg acaaatgaaa gttcaaggct ctaccttaac ctataaggat tgcaaagtat
      181 ggccaggagg cagtcgggct tgggattgga gagaaacagg aactgagcat tctcctggag
      241 tgcagccagc agacgtaaag gaagttgctg agaagggtgt acagactctt gtgattggca
      301 gaggaatgag cgaggccttg aaggtgcctc catcgactgt ggagtacctc gagaaacaag
      361 gcattgatgt gcgagtcctc cagacagagc aggcagtgaa ggagtacaat gccttggctg
      421 cccgggggat aagggtagga ggtgtcttcc attccacctg ctgatggagc ctacagagga
      481 gaataaacct ctgggcagca atgccttacc atctccacat cagcctcctc tgtgtacttt
      541 ggacacatgt tcatgttctt ggaacagatt gatgggaggc taaggcaaag ttcttgccct
      601 ccaggttgct taaatcagaa gagagatttg ctgattttag tattgtacta tgtgttcggt
      661 tcaaagtatg agaaagttca tacaaaaata aaggttgaag cttagaagcc aa
//
LOCUS       NM_001438146            1693 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant
            13, mRNA.
ACCESSION   NM_001438146 XM_008759398
VERSION     NM_001438146.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759398.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2155698.1,
                                           SRR26360186.2519042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000001.1  105129723-105129959
            238-375             JAXUCZ010000001.1  105130305-105130442
            376-543             JAXUCZ010000001.1  105130564-105130731
            544-716             JAXUCZ010000001.1  105131624-105131796
            717-1034            JAXUCZ010000001.1  105132438-105132755
            1035-1147           JAXUCZ010000001.1  105133588-105133700
            1148-1262           JAXUCZ010000001.1  105134128-105134242
            1263-1361           JAXUCZ010000001.1  105134333-105134431
            1362-1533           JAXUCZ010000001.1  105135522-105135693
            1534-1693           JAXUCZ010000001.1  105135873-105136032
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1693
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..237
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     exon            238..375
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1667
                     /gene="Tulp2"
                     /note="isoform 10 is encoded by transcript variant 13;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 10"
                     /protein_id="NP_001425075.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDV
                     EEVTMEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDP
                     TENSDRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQ
                     GDGDTSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGM
                     FPSYYLYLEAEDGVAVRSSPLGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGK
                     VRSNVLGTKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILP
                     GMDSRKQRMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVT
                     RASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE
                     "
     misc_feature    900..1649
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    900..1649
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            376..543
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..716
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1034
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1147
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1262
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1361
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1533
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1693
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtaggtt aagggagggg ctgttagact ggcttataat atttcagtgt tggggaggac
       61 cctaatgcat cgtggtggta gtggggcacg cggtagagca taggggcgtg gcttacttga
      121 gtgtgggcct ttatgaggga acataggggg agccttgtgg atccttctgc agaggattga
      181 ttgggttgtg ggtttcttaa aagctattga gaacatccag tcctgtggag tacccaggtg
      241 ttgggagccc tttcctccag gagaacgtac cacaggcaca tctgccctca ggggcacaca
      301 gtgcccttgt caccatgagc tatgtcggag atgggagtgg tgagcgggcc cctctactgt
      361 cacccagagg agcagtatac actcggggca atgggcctgc ggtccgccat ctctgctggc
      421 tcccagacag ctccgattca gatgtggagg aagtgaccat ggaagacatt cctgtcatct
      481 cccgacctcc caagacgcac ctggcaaacc gacgcagggg ctggttagcc tccccaggac
      541 ccgggatcag tgaagaggaa gaggttgaac ccaaggatgc cagagttgaa gacaagacac
      601 ccagcccaga cccagaccct acagaaaact ctgatagagt tcatggagac tcggcatcct
      661 gcaatatgga ggaaaacaca gccaaaaaga atatagaaac agcctctggc attggggatg
      721 aagacccgga gaagaaagag gccacagagt ctacagagac aaacaatgcc ctagtggcat
      781 ccaaggtctt gcaaggagat ggtgacacca gtaaccacag tgcttggaac atgacctgcc
      841 ccatgcctcg cactccaggt cctcggctcg gggaggacat ggaagcttac gtgttgctcc
      901 ctgcaccccg agaacacatg gtgcagtgcc gcatcgtccg aaacaagcat ggagtggaca
      961 agggcatgtt cccttcctac tacctctacc tggaggcaga ggatggtgta gcagtacgct
     1021 ccagcccttt ggggcatttc cttctggctg ggcggaaaag gaaacgaagc aaaacttcaa
     1081 attacctcat ctccctggac cccaaagaca tgtctcgcaa tgggaacaac tttgtaggca
     1141 aagttagatc taatgtcttg ggcacgaaat tcaccatctt tgataatggg gtgaaccctg
     1201 agcgtaacta ctggattcca gacagtgccc ggatcagaga ggagttggga gttgtatgtt
     1261 atgagaccaa tgtcttggga ttcagggggc ctcggaaaat gaccgtgatc ctcccaggaa
     1321 tggacagccg gaagcagagg atgaaagtac aaccacaaaa tgatcaggat tcaatactga
     1381 gtcgcgtaca gaaaggcgct agacatgggc tgctcctact gcagaacaag gccccatcgt
     1441 ggagcgacga aagcggcgca tacgtactca attttcatgg tcgcgtcacg cgggcttctg
     1501 tcaagaactt ccagatagtg cacccggatg aaccggacca cctggtgctc cagtttggcc
     1561 gtgtagcacc aaacatattc acgatggatt tccgatatcc tctttgcccg ctccaagcct
     1621 tcgccatctg cttatccagt ttcgatggga aactggcgtg tgagtaactg aataaaatac
     1681 catccctcac caa
//
LOCUS       NM_001106319            2994 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus cysteinyl-tRNA synthetase 1 (Cars1), transcript
            variant 2, mRNA.
ACCESSION   NM_001106319 XM_001065753 XM_215134
VERSION     NM_001106319.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Liu,C., Gamper,H., Shtivelband,S., Hauenstein,S., Perona,J.J. and
            Hou,Y.M.
  TITLE     Kinetic quality control of anticodon recognition by a eukaryotic
            aminoacyl-tRNA synthetase
  JOURNAL   J Mol Biol 367 (4), 1063-1078 (2007)
   PUBMED   17303165
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Davidson,E., Caffarella,J., Vitseva,O., Hou,Y.M. and King,M.P.
  TITLE     Isolation of two cDNAs encoding functional human cytoplasmic
            cysteinyl-tRNA synthetase
  JOURNAL   Biol Chem 382 (3), 399-406 (2001)
   PUBMED   11347887
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Kim,J.E., Kim,K.H., Lee,S.W., Seol,W., Shiba,K. and Kim,S.
  TITLE     An elongation factor-associating domain is inserted into human
            cysteinyl-tRNA synthetase by alternative splicing
  JOURNAL   Nucleic Acids Res 28 (15), 2866-2872 (2000)
   PUBMED   10908348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced NM_001106319.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.5215.1,
                                           SRR26643298.6165.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000001.1  208225271-208225345 c
            76-167              JAXUCZ010000001.1  208214606-208214697 c
            168-256             JAXUCZ010000001.1  208213181-208213269 c
            257-353             JAXUCZ010000001.1  208212543-208212639 c
            354-452             JAXUCZ010000001.1  208211830-208211928 c
            453-602             JAXUCZ010000001.1  208210555-208210704 c
            603-743             JAXUCZ010000001.1  208203165-208203305 c
            744-832             JAXUCZ010000001.1  208202131-208202219 c
            833-954             JAXUCZ010000001.1  208200700-208200821 c
            955-1067            JAXUCZ010000001.1  208198197-208198309 c
            1068-1196           JAXUCZ010000001.1  208197477-208197605 c
            1197-1326           JAXUCZ010000001.1  208197027-208197156 c
            1327-1430           JAXUCZ010000001.1  208196840-208196943 c
            1431-1528           JAXUCZ010000001.1  208196410-208196507 c
            1529-1718           JAXUCZ010000001.1  208195983-208196172 c
            1719-1787           JAXUCZ010000001.1  208195315-208195383 c
            1788-1869           JAXUCZ010000001.1  208191756-208191837 c
            1870-1950           JAXUCZ010000001.1  208188271-208188351 c
            1951-2018           JAXUCZ010000001.1  208187401-208187468 c
            2019-2078           JAXUCZ010000001.1  208185304-208185363 c
            2079-2162           JAXUCZ010000001.1  208184784-208184867 c
            2163-2994           JAXUCZ010000001.1  208183092-208183923 c
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2994
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA synthetase 1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
     exon            1..75
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    39..41
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="upstream in-frame stop codon"
     CDS             51..2297
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /EC_number="6.1.1.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cysteinyl-tRNA synthetase, cytoplasmic; cysteine--tRNA
                     ligase, cytoplasmic"
                     /codon_start=1
                     /product="cysteine--tRNA ligase, cytoplasmic isoform 2"
                     /protein_id="NP_001099789.1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
                     /translation="MAGSSAEQGKGRRVQPQWSPPAGTEPCRLRLYNSLTRNKDVFIP
                     QDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLRDYFQYDVFYCMNITDIDDKI
                     IRRARQNYLFEQYREQKPSAAQLLKDVGDAMKPFSVKLSETTDPDKRQMLERIQNSVK
                     LATEPLEQAVHSNPSGEEVDSRVQVLLEEAKDLLSDWLDSTGGSEVTDNSIFSKLPKF
                     WEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSVYFDTAKFA
                     ASEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSWP
                     CPWGKGRPGWHIECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVR
                     YFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTME
                     SALQYEKFMNEFFLNVKDILRAPVDITGQFEKWEAEEVELNKNFYDKKTAVHEALCDN
                     IDTRTVMEEMRALVSQCNLYMAARKAARRRPNRALLENIAMYLTHMLKIFGAIEEENP
                     LGFPVGGPGTNLNLESTVMPYLQVLSEFREGVRKIAREKKVLEVLQLSDALRDDILPE
                     LGVRFEDHEGLPTVVKLVDRDTLLKEKEEKKRAEEEKRRKKEEAARKKQEQEAAKLAK
                     MKTPPSEMFRSETDKYSKFDENGLPTHDTEGKELSKGQTKKLKKLFEAQEKVYKEYLQ
                     QLQNSSLQ"
     misc_feature    51..2285
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     misc_feature    51..2285
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     exon            76..167
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            168..256
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            257..353
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            354..452
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            453..602
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            603..743
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            744..832
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            833..954
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1067
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1196
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1326
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1430
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1528
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1718
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1787
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1869
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1950
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2018
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2078
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2162
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2994
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattctgga aagcgtctgt ggcggcagac gcgggtcttg attcccagtg atggcaggtt
       61 cctccgcgga gcagggtaaa ggccggcgag tgcagcctca gtggtcccct ccagcaggga
      121 ctgagccctg ccggctccgc ctatacaata gcctcacccg gaacaaggat gtatttatac
      181 ctcaagatgg gaagaaggtg acgtggtact gttgcgggcc gactgtctat gatgcgtctc
      241 acatgggaca tgccaggtcc tacatctctt tcgatatcct gcggagggtg ctgagggatt
      301 acttccagta tgatgtcttt tactgcatga acatcacaga cattgatgat aagatcatca
      361 ggagggcgcg gcagaactac ctgtttgagc agtatcggga gcagaaacct tcggctgccc
      421 agcttctgaa ggatgttggt gatgccatga agccattctc agtcaagtta agtgagacaa
      481 cagaccctga caagaggcag atgctggaga ggatccagaa ctctgtgaag cttgccacag
      541 aaccactgga acaggctgtg cattccaacc cctctggaga ggaagtagac agccgtgtac
      601 aggtgttgct ggaggaagca aaggacttgc tctctgactg gctggattct acaggtggca
      661 gtgaggtgac tgacaactct attttctcca aactgcccaa gttctgggaa gaagagttcc
      721 acaaagacat ggaagccctg aatgttctcc ctcctgatgt cctgacccgt gtcagtgaat
      781 atgtgccgga aattgtgaac ttcgtccaga agattgtgga caacggttat ggctatgctt
      841 caaatgggtc tgtctacttc gacacagcca agttcgctgc tagtgaaaag cactcctatg
      901 gcaagctggt gcctgaggct gttggggatc agaaagcact tcaggaaggg gaaggtgatc
      961 tgagcatctc tgctgaccgc cttagtgaga aacgctctcc caatgacttc gccttgtgga
     1021 aggcctccaa gccaggagag ccatcctggc cttgcccctg gggaaagggt cgtccaggat
     1081 ggcacataga gtgctccgct atggcaggct cgctcctggg agcctcaatg gacattcatg
     1141 gtggaggctt tgacctccgc ttcccccacc atgacaatga gctggcacag tcagaggcct
     1201 actttgagaa tgactgctgg gtcaggtact tcttgcacac gggccacttg acaatagcag
     1261 gctgcaagat gtccaagtca ctgaaaaact tcatcaccat caaagatgcc ttgaagaagc
     1321 actcagcacg gcagctgcgg ctggctttcc tcatgcactc ctggaaagac acactggact
     1381 attccagcaa cactatggag tctgcacttc agtatgaaaa gttcatgaat gaatttttct
     1441 taaacgtgaa agacatcctc cgagcccctg tggacatcac tggccagttt gaaaagtggg
     1501 aagccgaaga agtggagctc aataagaact tctatgacaa gaagaccgca gttcatgaag
     1561 ccctgtgtga taacattgac acccgtactg tcatggagga gatgcgggct ttggtcagtc
     1621 agtgcaacct ctacatggca gccaggaagg ccgcaaggag gaggcccaac agggctctgc
     1681 tggaaaacat tgccatgtac ctcacccaca tgctgaagat ctttggagcc atagaggagg
     1741 agaaccccct gggtttcccg gttggtgggc ctggaaccaa cctgaatctc gagtctacag
     1801 tcatgcccta cctgcaggta ttatcggaat tcagggaggg tgtgcgaaag attgcccgag
     1861 agaaaaaagt ccttgaggtt ctgcagctca gtgatgccct ccgggatgac atcctgcctg
     1921 agcttggggt gcggtttgaa gaccacgaag gactgccaac agtggtgaag ttggtggaca
     1981 gagacacctt actgaaagag aaggaagaaa agaaaagggc tgaagaagag aagaggagga
     2041 agaaagagga ggcggccagg aagaaacagg agcaagaagc agcaaagctg gccaagatga
     2101 agacgccacc cagtgagatg ttccgctcag aaaccgacaa gtattctaag tttgatgaaa
     2161 atggtctgcc tacccacgac actgaaggca aagagctgag caagggccag accaagaagt
     2221 tgaagaagct ctttgaagct caggagaaag tgtacaagga gtatctgcaa cagttgcaga
     2281 atagcagcct ccagtgatac caccgcagcc cagaaggggt ccctgccagc ctggccgaca
     2341 tggactaggc cacacggctc aggcccgccc tcatcatgtt tacagctgct ctcacacctg
     2401 aatcaggcag agtggtagca gctctgggac actggtaata aattcttctg aaccaccggc
     2461 aaggcccggt ctgccctctc agcactgggg cgagctggcc tacaggtgcc tgctcagcag
     2521 cttgggactt aggcctcctg gtcagttgag ccccttcagc cagcctgccg gaggaatttc
     2581 cctcacatcg gcgggccgag ctaatctctg ctgtgttggc acgtttggtg gtattggagt
     2641 aggaaaaagg ccgactcagc ccaacggatc cccctgagcc ccagacaaaa gccactcagt
     2701 tgtctgtctg gctctgatga acacacactg caggtttccc agagcaactg acaaagtggc
     2761 agcaggacag ttgccctgtg ggatggggct ctggcaagct gcctgcgact gccgttatga
     2821 cagcaagccc agatcagcac cacggcttgt aagataaggg attctctagt ccaacctgaa
     2881 gtgtttctcc tctccacctg ctcctgcctg tttgttcgcc cttgccaaga atcagcacct
     2941 atgctgaatg tgtctagcct tctctaatga ttaaaaagaa aagaaagaaa ggta
//
LOCUS       NM_001438132            1383 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus proline rich and Gla domain 2 (Prrg2), transcript
            variant 2, mRNA.
ACCESSION   NM_001438132
VERSION     NM_001438132.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.1676.1,
                                           SRR26643294.2327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000001.1  104678978-104679120 c
            144-297             JAXUCZ010000001.1  104678247-104678400 c
            298-479             JAXUCZ010000001.1  104677743-104677924 c
            480-519             JAXUCZ010000001.1  104677511-104677550 c
            520-661             JAXUCZ010000001.1  104673619-104673760 c
            662-790             JAXUCZ010000001.1  104671671-104671799 c
            791-1383            JAXUCZ010000001.1  104670748-104671340 c
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1383
                     /gene="Prrg2"
                     /note="proline rich and Gla domain 2"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     exon            1..143
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    90..92
                     /gene="Prrg2"
                     /note="upstream in-frame stop codon"
     exon            144..297
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..809
                     /gene="Prrg2"
                     /note="transmembrane gamma-carboxyglutamic acid protein 2;
                     proline-rich Gla (G-carboxyglutamic acid) polypeptide 2;
                     proline rich Gla (G-carboxyglutamic acid) 2"
                     /codon_start=1
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     2 precursor"
                     /protein_id="NP_001425061.1"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
                     /translation="MRSHPSLLLVYMGLATCLDTLPHREQSQVLDIFLDAPEAQSFLV
                     GRRRFPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYAYNGKG
                     GRGRVDVAGLAVGLTSGILLIVLAGLGAFWYLHYRRRRLRVQESCLQETGLIIPLSPP
                     TPLSPPPPPGLPTYEQALAASGVHDAPPPPYSSLRRPH"
     sig_peptide     213..263
                     /gene="Prrg2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    309..500
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     misc_feature    309..500
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     exon            298..479
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..519
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..661
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..790
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1383
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggatcg ggcctagtac cagaggtgga gcacccctcc tccttctccc ctcccctctc
       61 ccttacccct ttgcacagct ggctactgct aacccagagg gtcttcattc aagaagagaa
      121 gcaggcctcc cagccctgga cagagtctgg gcagggagtc ctggggcctc ataactctgc
      181 tgaggcattt gtcatctggg agttcacaca atatgaggag ccatccttcc ctgctcttag
      241 tctacatggg attggccacc tgcctggaca ccttacctca tagagagcaa agccaagttc
      301 ttgacatctt cctggatgcc ccagaggccc agagtttctt agttggccgc aggcgttttc
      361 ctcgtgctaa ccactgggac ctggagttgc tgacccctgg gaacctggaa cgggagtgtc
      421 tggaagagag gtgctcctgg gaggaggccc gggagtactt tgaggacaac acactgacgg
      481 agcgtttctg ggaaagctat gcatacaacg gcaagggagg gcgtggacgg gtggatgttg
      541 caggcctggc agtgggactg acctctggga tcctgctcat cgtgttggct ggcttgggag
      601 ccttttggta tctgcattat cgacggcgcc gcctcagagt ccaggagtcc tgtctgcaag
      661 agaccgggct catcatcccc ttaagtcctc cgacgcctct gtctccaccg cctcccccag
      721 gccttcccac ctatgagcag gctttagcag cctccggggt gcacgacgcc cctccacccc
      781 cttactccag cctcagaagg ccccactgaa gacctgctcc gagcgcgggc tccctcaact
      841 gtgcccctga ttcatagcgg attccggaag tcgccggctt cttcgacgac taggcttcag
      901 tgtgtccgtg ggggagtcgg ggtcgtcgga cccggggtct acatgacaca cgtgtttccg
      961 ccgggcacgc atacacgcat gtccctgacc atcctgttgc cgagtcggtg cccctggccc
     1021 gcgcgtgaac ccccacttct gctgagcctt gcctcagaat ggacagactt tttaggaaac
     1081 tcggaccaga cgtgactcgg ctgtcacccc actggtgccg cggagcgcgt acactcaggg
     1141 aaccaggccc ttacacacgc cttacttggt gtatttcccc actcgtgcac atgggcggtt
     1201 cgtaatccag cataaagatg gggggcacat ttgcaatgtg ctgtaagtgg ggtgtcaacg
     1261 cttgtgttgc acccgggtaa atggagttga tctgagctgc cctttactta aaaacccttt
     1321 gggaaaaggg tggaagaaat taaaattgaa acaataagaa aaataaaaat gcaaaagaac
     1381 tga
//
LOCUS       NM_001438219            3207 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 6, mRNA.
ACCESSION   NM_001438219
VERSION     NM_001438219.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1937899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680425
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              JAXUCZ010000001.1  191913797-191914936 c
            1141-1166           JAXUCZ010000001.1  191909898-191909923 c
            1167-1835           JAXUCZ010000001.1  191907790-191908458 c
            1836-3207           JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3207
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..1140
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1069..1071
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     exon            1141..1166
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1835
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             1189..3048
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425148.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    1258..1320
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1258..1320
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1381..2445
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1381..2445
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1444..1506
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1444..1506
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1528..1590
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1528..1590
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1612..1674
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1612..1674
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1696..1758
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1696..1758
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1780..1842
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1780..1842
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1864..1926
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1864..1926
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1879..1881,1885..1887,1891..1893,1897..1902,
                     1909..1914,1921..1923,1963..1965,1969..1971,1981..1986,
                     1993..1998,2005..2007,2047..2049,2053..2055,2059..2061,
                     2065..2070,2077..2082,2089..2091)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1879..1881,1885..1887,1891..1893,1897..1902,
                     1909..1914,1921..1923,1963..1965,1969..1971,1981..1986,
                     1993..1998,2005..2007,2047..2049,2053..2055,2059..2061,
                     2065..2070,2077..2082,2089..2091)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1930..2982
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1930..2982
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1948..2010
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1948..2010
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2032..2094
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2032..2094
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2116..2178
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2116..2178
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2200..2262
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2200..2262
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2284..2346
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2284..2346
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2368..2430
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2368..2430
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2740..2802
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2740..2802
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2755..2757,2761..2763,2767..2769,2773..2778,
                     2785..2790,2797..2799,2839..2841,2845..2847,2857..2862,
                     2869..2874,2881..2883,2923..2925,2929..2931,2935..2937,
                     2941..2946,2953..2958,2965..2967)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2755..2757,2761..2763,2767..2769,2773..2778,
                     2785..2790,2797..2799,2839..2841,2845..2847,2857..2862,
                     2869..2874,2881..2883,2923..2925,2929..2931,2935..2937,
                     2941..2946,2953..2958,2965..2967)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2824..2886
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2824..2886
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2908..2970
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2908..2970
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1836..3207
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcctaaag aacgccattt tgcaggcctt tgtcctgttc tggatcctct gtccattcat
       61 ttcttcagtc cttccttctt cattcattct gtcctgttcc gctcgccgaa gccacgttat
      121 cctagggttt agtcccaaat gagtcagcat acagccccgc tctgcgggag ctgcctgtct
      181 ggcgaggaca cccgcacaaa cacggttgca gagagcgagg aacgctgggt ttctgcaggt
      241 cttgtccctc ctcagagagt ctggtaggcc ctacaccctg caaaatccca tatgcttcag
      301 ggactccatt ccactgaaga aattgaggcc cctagctcta cgcatccctc atttttactg
      361 ctcgttaaat attcttgtgg ggaatggagt attggaagca tgcaagtatc ctcccgtggg
      421 agaaggaaaa cgagggctgg ctcctgggca aaggaaattg catatggagg tggcaaagtt
      481 tgtgaattgt tgatggagct tagactcctg accagagagg acactgctgt agaaactgag
      541 ggtggaaaaa tgggatcatg ttgtgagctg actggttgtt aggcctagga catcattaaa
      601 cgttcaccac aacacaattt catcaattca ccgaaaggct caaggtttgt ggggcttgta
      661 tgttggctta tttgaagctt gtatgtaggt gcctttctta ttgtttcaac cacacctgtg
      721 ctgctcccca aaccaccccg atttaggggg caccgagtct cattaactta aagtaagata
      781 tcattctcct cattgggttt tatcacacag taaacaaatt ggagtactag tgtgatactt
      841 gaaccctgtg accgtgtaag aacggggcat ttcagttaaa tagttggtga ctgactctca
      901 cagactccta tggtggaaga ggcagaggct atagacctcg gcgtgaattc caccagtttg
      961 cttttggtca ccagttttgg aataacaagg gtatagaaca aagttctcag gaccctagtg
     1021 ctggaggtga aaaattaagg cccaaatatt aaaatgtgct agtgctaata aagcagtcgt
     1081 caaggggaca gatggcagaa actttggtat ctgactactt ggcttcaaat accagctgag
     1141 aacctttcag gggctccact gaccagagaa ggtctactca ccgaggccat ggaagtggag
     1201 gctgcagagg ccaagtcccc aggcccctgc tacaagcgct ctggccgccg ttataagtgc
     1261 ctgttttgta caaagacatt tccaaatgct cccagggcag cccgccatgc tgctacacat
     1321 acaactacag actgcacaga ggaggtgaat gaggtccagc cgaaggtgga tgcagagccc
     1381 aaggctgagg aagccagtgg agacaaggta tctgggtcag tagccaagcc ccggccctat
     1441 gcttgccctc tgtgccccaa ggcctacaag acagctcctg agctacgcag ccatggacgc
     1501 agccacactg gtgagaagcc cttcccgtgc ccagagtgcg gccgccgttt catgcagcca
     1561 gtgtgcctgc gtgtgcacct ggcctcacac gctggtgagc tgcctttccg atgcacacac
     1621 tgccccaagg cttatggtac actctctaaa ctaaagatcc accagcgtgg gcacacaggc
     1681 gagcggccct atgcctgtac tgactgcggc aagagctttg ctgatccttc agtgttccgc
     1741 aagcatcggc gcacgcatgc aggcctgcgc ccctacagct gcgagcgctg cggcaaggcc
     1801 tatgctgagc tgaaggactt acgcaaccac gaaaggtccc acacgggtga gcgccccttc
     1861 ctctgctcag agtgtggtaa aagcttctct cgatcctctt ccctcacatg ccatcagcgt
     1921 atccatgcag cccagaaacc ctatcgctgc ccggcttgtg gtaagggctt cacacagctc
     1981 agctcttacc aaagccatga gcgcacacat tcaggcgaaa agcccttcct gtgccctcgg
     2041 tgtggccgca tgttctctga tccctcgagc ttccgccgcc accagcgggc acatgagggt
     2101 gtaaagcctt accgctgtga gaaatgtggc aaggacttcc ggcagccagc tgacctggcc
     2161 atgcaccgtc gagtacacac cggcgaccga cccttcaagt gcctgcagtg tgacaagact
     2221 tttgtggctt cctgggacct caagcggcat gcattggtac actcaggaca gcggccgttc
     2281 cgctgtgagg agtgtgggcg agcatttgct gagcgagcta gccttacaaa gcacagccgc
     2341 atgcactctg gcgagcgtcc tttccactgt aatgcctgcg ggaaatcctt tgtggtgtta
     2401 tccagcctca ggaagcatga gcgcacccat agaagcaacg agactacggg agctgccccc
     2461 cagcaggagt tggtactggg actagcactg cctgtaggtg tcgtaggtga gggctcagct
     2521 gcccctgtgg caggtgcagg gataggggat gctccagcag ggctgctagg gttaccgcct
     2581 gagtctggta gtgtagtggc cacacagtgg caagtggtgg gcatgactgt agagcatgtg
     2641 gagtgccagg atgctggcgt tggcgaagct cctagtaccc tgggagatgc aggagaggtg
     2701 ggtggggagg agactgatga gaagccccca cagtttgtgt gtcgagagtg caaagaaact
     2761 ttctccacac tgacattgct acgcaggcat gaacgctcac acccagagct ccggcccttt
     2821 ccctgcaccc agtgtggtaa gagcttctca gacagggctg ggcttcgtaa gcatagccgc
     2881 acccacagct ctgtacgccc ctactcctgt tcccaatgtc ctaaagcttt cctgagtgcc
     2941 agtgatctgc gcaaacatga acgcacccac cctgtgccca tcgggacccc catacccctg
     3001 gaaccccttg tggctctgct aggaatgcca gaagaagggt cagcctgaag tttatagatc
     3061 tccactacac tcccagaagg ccatccctag tctccaaacc cctgcctctg ggcagctagc
     3121 tcagttctcg tccactaaga gctgtggaca gtggaagctg gtagcatttg tgagaggtac
     3181 tcattaaagc attggctttg ataccaa
//
LOCUS       NM_001438134            1850 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant 1,
            mRNA.
ACCESSION   NM_001438134 XM_006229103
VERSION     NM_001438134.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229103.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3147.1,
                                           SRR26360181.2188588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  105127650-105127699
            51-83               JAXUCZ010000001.1  105128090-105128122
            84-135              JAXUCZ010000001.1  105128567-105128618
            136-274             JAXUCZ010000001.1  105129353-105129491
            275-412             JAXUCZ010000001.1  105130305-105130442
            413-580             JAXUCZ010000001.1  105130564-105130731
            581-753             JAXUCZ010000001.1  105131624-105131796
            754-1071            JAXUCZ010000001.1  105132438-105132755
            1072-1184           JAXUCZ010000001.1  105133588-105133700
            1185-1299           JAXUCZ010000001.1  105134128-105134242
            1300-1398           JAXUCZ010000001.1  105134333-105134431
            1399-1570           JAXUCZ010000001.1  105135522-105135693
            1571-1696           JAXUCZ010000001.1  105135873-105135998
            1697-1850           JAXUCZ010000001.1  105136090-105136243
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1850
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..50
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1704
                     /gene="Tulp2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 1"
                     /protein_id="NP_001425063.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MDREGPRGPRRGTSQENEQWKKETLEDEFSGVRLQKLEQQRQLF
                     EKKQRRKRQEPLMVQANPDASLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQAHL
                     PSGAHSALVTMSYVGDGSGERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVT
                     MEDIPVISRPPKTHLANRRRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENS
                     DRVHGDSASCNMEENTAKKNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGD
                     TSNHSAWNMTCPMPRTPGPRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSY
                     YLYLEAEDGVAVRSSPLGHFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSN
                     VLGTKFTIFDNGVNPERNYWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDS
                     RKQRMKVQPQNDQDSILSRVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASV
                     KNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLAFF"
     misc_feature    130..>651
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    130..>651
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    937..1686
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    937..1686
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            51..83
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..135
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..274
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..412
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..580
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..753
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1071
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1184
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1299
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1398
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1570
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1696
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1850
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactctgt tggacatgga ccgtgagggg cctagagggc caagaagagg aacgtctcaa
       61 gagaatgaac agtggaagaa agagaccttg gaggatgaat tctctggtgt gaggctgcag
      121 aagctggaac aacagcgaca gctatttgag aagaagcagc gccggaaacg ccaggagccc
      181 ctcatggttc aggccaatcc tgatgcttcc ctgaggcacc ggcgaccaag gcgtggggag
      241 gagcgcttcc agagtgacag cagctggggc cttggtgttg ggagcccttt cctccaggag
      301 aacgtaccac aggcacatct gccctcaggg gcacacagtg cccttgtcac catgagctat
      361 gtcggagatg ggagtggtga gcgggcccct ctactgtcac ccagaggagc agtatacact
      421 cggggcaatg ggcctgcggt ccgccatctc tgctggctcc cagacagctc cgattcagat
      481 gtggaggaag tgaccatgga agacattcct gtcatctccc gacctcccaa gacgcacctg
      541 gcaaaccgac gcaggggctg gttagcctcc ccaggacccg ggatcagtga agaggaagag
      601 gttgaaccca aggatgccag agttgaagac aagacaccca gcccagaccc agaccctaca
      661 gaaaactctg atagagttca tggagactcg gcatcctgca atatggagga aaacacagcc
      721 aaaaagaata tagaaacagc ctctggcatt ggggatgaag acccggagaa gaaagaggcc
      781 acagagtcta cagagacaaa caatgcccta gtggcatcca aggtcttgca aggagatggt
      841 gacaccagta accacagtgc ttggaacatg acctgcccca tgcctcgcac tccaggtcct
      901 cggctcgggg aggacatgga agcttacgtg ttgctccctg caccccgaga acacatggtg
      961 cagtgccgca tcgtccgaaa caagcatgga gtggacaagg gcatgttccc ttcctactac
     1021 ctctacctgg aggcagagga tggtgtagca gtacgctcca gccctttggg gcatttcctt
     1081 ctggctgggc ggaaaaggaa acgaagcaaa acttcaaatt acctcatctc cctggacccc
     1141 aaagacatgt ctcgcaatgg gaacaacttt gtaggcaaag ttagatctaa tgtcttgggc
     1201 acgaaattca ccatctttga taatggggtg aaccctgagc gtaactactg gattccagac
     1261 agtgcccgga tcagagagga gttgggagtt gtatgttatg agaccaatgt cttgggattc
     1321 agggggcctc ggaaaatgac cgtgatcctc ccaggaatgg acagccggaa gcagaggatg
     1381 aaagtacaac cacaaaatga tcaggattca atactgagtc gcgtacagaa aggcgctaga
     1441 catgggctgc tcctactgca gaacaaggcc ccatcgtgga gcgacgaaag cggcgcatac
     1501 gtactcaatt ttcatggtcg cgtcacgcgg gcttctgtca agaacttcca gatagtgcac
     1561 ccggatgaac cggaccacct ggtgctccag tttggccgtg tagcaccaaa catattcacg
     1621 atggatttcc gatatcctct ttgcccgctc caagccttcg ccatctgctt atccagtttc
     1681 gatgggaaac tggcgttttt ttgatactca gtctggtctc caacaactat gtagctgagg
     1741 cttgccttga acctccgatc ctcctgctct ctgaagtgct gggatgacaa gcatgcacct
     1801 ttgtgcctgg ccttgtcttt taacaataaa tcttttgatt aattttttta
//
LOCUS       NM_001438201            2382 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), transcript
            variant 4, mRNA.
ACCESSION   NM_001438201 XM_039078166
VERSION     NM_001438201.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2382)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2382)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2382)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2382)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2382)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.3700.1,
                                           SRR26360190.2710764.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  168149213-168149262 c
            51-526              JAXUCZ010000001.1  168141182-168141657 c
            527-622             JAXUCZ010000001.1  168139744-168139839 c
            623-782             JAXUCZ010000001.1  168138077-168138236 c
            783-805             JAXUCZ010000001.1  168135410-168135432 c
            806-906             JAXUCZ010000001.1  168134230-168134330 c
            907-933             JAXUCZ010000001.1  168133975-168134001 c
            934-2382            JAXUCZ010000001.1  168132277-168133725 c
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2382
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..50
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            51..526
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            527..622
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            623..782
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    741..743
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="upstream in-frame stop codon"
     CDS             765..1571
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 4;
                     tripartite motif-containing protein 5"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform 5"
                     /protein_id="NP_001425130.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MSILSRGVENTIKRSHTFSMRKPKTIPKEQRRVFRAPDLQGMLQ
                     VLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARPTENCHAGVLGY
                     PAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPLFRLNLSNDSHS
                     RLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLMVRPCRVGIFLD
                     CAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICWPDS"
     misc_feature    903..1556
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     misc_feature    903..1556
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            783..805
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            806..906
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            907..933
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            934..2382
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtgtgg cagctgccct gaactacatc atcctttcgg ttctcatcct gcacctgagc
       61 agacgtgtga ggagtcagta gagtcagaca caggatcaca gcaactatgg cttcagaatt
      121 cgtgatgaat ttaaaagagg aggtgacctg tcctatctgc ctggacctga tggtagaacc
      181 tgtgagtgga gattgtggtc acagcttctg ccaagcctgc atcacgctga actatgaatc
      241 cagcaaatgc aatcaggatg agttcatttg ccctgtgtgc cgagttagtt acctgtttaa
      301 gaacctgagg cccaatcgac atgtggccaa catagtgcag aggctcaaag agttcaagtc
      361 cagcccagaa gaggagccga aggtgctttc ttgtgcaagg catggagaga aactccagct
      421 cttctgtaag aaggacatga tgcccatctg ctggctttgt gagcgatctc aggagcaccg
      481 tggacaccaa acagttctca ttgaagaggt ggtccaggag tataaggaga agctgcaggc
      541 agctctgcaa aagctgatgg cagacaagaa agaatttgag aactggaaag atgaccttca
      601 aaaggagaga acttactggc agaatcaaat acagaaagat gtggaaaatg tccagtcaga
      661 gtttaaagga atgagagata tcatggactc tgaggagaag aaggaattgc agaagctgat
      721 gcaagagaag gaagacatta tgagcagcct ggaagagtct gaaaatgagt attctcagca
      781 gaggtgtaga gaacaccata aaacggagtc atactttttc gatgaggaag cccaaaacca
      841 tccccaagga acaaagaaga gtgttccgag cccctgatct gcaaggcatg ctgcaagtgt
      901 tacaagaggt cacagaggcc caacgctact gggttcaagt gacgctggtt gaaagcaaca
      961 atccaaacat tttcattacc gccgacaaaa gacagatacg atatgaagac caccaagcaa
     1021 gacattttgc ccgtccgact gaaaactgtc atgcaggtgt cctgggatac ccagctatcc
     1081 aatcaggaaa acactactgg gaagtagatg tgtctggaaa aggttcttgg gttctgggat
     1141 taagtgatgg aagctacctc tttaatccaa tatttcgttc aaatgcagaa agacccccaa
     1201 accccccctt atttcgtttg aatcttagta atgattcaca ttctcgtttg agtcttagta
     1261 atgattcaca ttatcaacct aaatatggct tctgggttat agggctgtgg ggaaattctg
     1321 tgtataatgc ttttgaggag tgtacgttca caggcaagcc cagtgtgttg accctctctc
     1381 tgatggtccg accctgtcgt gtcggtattt tcctcgactg tgcagctggc accctctcgt
     1441 tttacaatat ttccaaccat ggcactctta tctacagatt ctgtgcaggt tcctttcctg
     1501 atagggtttt tccatatttt aaccccatgg gaagttcaga gccattgaca atatgctggc
     1561 cagactctta atcttcactg tctctgtgca tggtctctgg tcctgatgtg tatgtcatgt
     1621 gcctgagctc atcagcacta ttttatcgtt ttgttcatgt ctctaatctt tcattggaaa
     1681 atatattcat ttctctaggc catattctca gtttcttggg gtattttttg tctttgtttt
     1741 gttttgtttt taggtgagac taacaaatca cttcccatat agtcaaggac aaatgtctag
     1801 tgctcactgc gtaagataac accgatgcaa aattcctctt attcttcatg ccagagatgg
     1861 aaggcaaggc cttgtgcacg gtgaggatgt gctccaccgc tgagctgttt gcttcagctg
     1921 tcatgtccct ataacctcat tcggcccatc aatgaaagat taaagaaggt tcttcgacaa
     1981 cttgtctatt catgctgaaa attatatata ggagtctctg cttaagaaat gcaccctgag
     2041 ctgtaggcca aagaatgaag gagaagcatc acaagaagcc ttatcactgt gactaaatta
     2101 agtgatcatt aagactgtgc atcagtcttg cctgggagct catacctgcc atcctgcatc
     2161 tgggaagttg tggcaggaag attgctgtgt atttgaagcc acccttgtat agagttaaga
     2221 gcctgcttaa aaaaaataat caagaatatg tataaaaacc actactctat tttgttctaa
     2281 gaaatagaat aactagattt cagaattgca gggtttgggt cgttttcaca atttgtaaat
     2341 aaatgtttac taaaaataaa tgttaacttc atagctgtcc aa
//
LOCUS       NM_001014023            2453 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), transcript
            variant 1, mRNA.
ACCESSION   NM_001014023 XM_219046
VERSION     NM_001014023.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2453)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2453)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2453)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2453)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced NM_001014023.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078926.1, SRR26643298.4371.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  168149213-168149262 c
            51-526              JAXUCZ010000001.1  168141182-168141657 c
            527-622             JAXUCZ010000001.1  168139744-168139839 c
            623-853             JAXUCZ010000001.1  168138006-168138236 c
            854-876             JAXUCZ010000001.1  168135410-168135432 c
            877-977             JAXUCZ010000001.1  168134230-168134330 c
            978-1004            JAXUCZ010000001.1  168133975-168134001 c
            1005-2453           JAXUCZ010000001.1  168132277-168133725 c
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2453
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..50
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            51..526
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    68..70
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="upstream in-frame stop codon"
     CDS             107..1642
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif-containing protein 5"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform 1"
                     /protein_id="NP_001014045.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MASEFVMNLKEEVTCPICLDLMVEPVSGDCGHSFCQACITLNYE
                     SSKCNQDEFICPVCRVSYLFKNLRPNRHVANIVQRLKEFKSSPEEEPKVLSCARHGEK
                     LQLFCKKDMMPICWLCERSQEHRGHQTVLIEEVVQEYKEKLQAALQKLMADKKEFENW
                     KDDLQKERTYWQNQIQKDVENVQSEFKGMRDIMDSEEKKELQKLMQEKEDIMSSLEES
                     ENEYSQQSKLLGDLILDVEHQLQCSATEMLQGVENTIKRSHTFSMRKPKTIPKEQRRV
                     FRAPDLQGMLQVLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARP
                     TENCHAGVLGYPAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPL
                     FRLNLSNDSHSRLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLM
                     VRPCRVGIFLDCAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICW
                     PDS"
     misc_feature    128..340
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    128..340
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    order(152..157,161..166,272..277,281..283)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    order(152..157,161..166,272..277,281..283)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    389..505
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    389..505
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    500..>805
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    500..>805
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    974..1627
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     misc_feature    974..1627
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            527..622
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            623..853
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            854..876
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            877..977
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1004
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..2453
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtgtgg cagctgccct gaactacatc atcctttcgg ttctcatcct gcacctgagc
       61 agacgtgtga ggagtcagta gagtcagaca caggatcaca gcaactatgg cttcagaatt
      121 cgtgatgaat ttaaaagagg aggtgacctg tcctatctgc ctggacctga tggtagaacc
      181 tgtgagtgga gattgtggtc acagcttctg ccaagcctgc atcacgctga actatgaatc
      241 cagcaaatgc aatcaggatg agttcatttg ccctgtgtgc cgagttagtt acctgtttaa
      301 gaacctgagg cccaatcgac atgtggccaa catagtgcag aggctcaaag agttcaagtc
      361 cagcccagaa gaggagccga aggtgctttc ttgtgcaagg catggagaga aactccagct
      421 cttctgtaag aaggacatga tgcccatctg ctggctttgt gagcgatctc aggagcaccg
      481 tggacaccaa acagttctca ttgaagaggt ggtccaggag tataaggaga agctgcaggc
      541 agctctgcaa aagctgatgg cagacaagaa agaatttgag aactggaaag atgaccttca
      601 aaaggagaga acttactggc agaatcaaat acagaaagat gtggaaaatg tccagtcaga
      661 gtttaaagga atgagagata tcatggactc tgaggagaag aaggaattgc agaagctgat
      721 gcaagagaag gaagacatta tgagcagcct ggaagagtct gaaaatgagt attctcagca
      781 gagtaagttg ctaggagacc tcatcttaga tgtggaacat cagttacaat gctcagccac
      841 ggaaatgctg cagggtgtag agaacaccat aaaacggagt catacttttt cgatgaggaa
      901 gcccaaaacc atccccaagg aacaaagaag agtgttccga gcccctgatc tgcaaggcat
      961 gctgcaagtg ttacaagagg tcacagaggc ccaacgctac tgggttcaag tgacgctggt
     1021 tgaaagcaac aatccaaaca ttttcattac cgccgacaaa agacagatac gatatgaaga
     1081 ccaccaagca agacattttg cccgtccgac tgaaaactgt catgcaggtg tcctgggata
     1141 cccagctatc caatcaggaa aacactactg ggaagtagat gtgtctggaa aaggttcttg
     1201 ggttctggga ttaagtgatg gaagctacct ctttaatcca atatttcgtt caaatgcaga
     1261 aagaccccca aaccccccct tatttcgttt gaatcttagt aatgattcac attctcgttt
     1321 gagtcttagt aatgattcac attatcaacc taaatatggc ttctgggtta tagggctgtg
     1381 gggaaattct gtgtataatg cttttgagga gtgtacgttc acaggcaagc ccagtgtgtt
     1441 gaccctctct ctgatggtcc gaccctgtcg tgtcggtatt ttcctcgact gtgcagctgg
     1501 caccctctcg ttttacaata tttccaacca tggcactctt atctacagat tctgtgcagg
     1561 ttcctttcct gatagggttt ttccatattt taaccccatg ggaagttcag agccattgac
     1621 aatatgctgg ccagactctt aatcttcact gtctctgtgc atggtctctg gtcctgatgt
     1681 gtatgtcatg tgcctgagct catcagcact attttatcgt tttgttcatg tctctaatct
     1741 ttcattggaa aatatattca tttctctagg ccatattctc agtttcttgg ggtatttttt
     1801 gtctttgttt tgttttgttt ttaggtgaga ctaacaaatc acttcccata tagtcaagga
     1861 caaatgtcta gtgctcactg cgtaagataa caccgatgca aaattcctct tattcttcat
     1921 gccagagatg gaaggcaagg ccttgtgcac ggtgaggatg tgctccaccg ctgagctgtt
     1981 tgcttcagct gtcatgtccc tataacctca ttcggcccat caatgaaaga ttaaagaagg
     2041 ttcttcgaca acttgtctat tcatgctgaa aattatatat aggagtctct gcttaagaaa
     2101 tgcaccctga gctgtaggcc aaagaatgaa ggagaagcat cacaagaagc cttatcactg
     2161 tgactaaatt aagtgatcat taagactgtg catcagtctt gcctgggagc tcatacctgc
     2221 catcctgcat ctgggaagtt gtggcaggaa gattgctgtg tatttgaagc cacccttgta
     2281 tagagttaag agcctgctta aaaaaaataa tcaagaatat gtataaaaac cactactcta
     2341 ttttgttcta agaaatagaa taactagatt tcagaattgc agggtttggg tcgttttcac
     2401 aatttgtaaa taaatgttta ctaaaaataa atgttaactt catagctgtc caa
//
LOCUS       NM_001438222            2180 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 9, mRNA.
ACCESSION   NM_001438222
VERSION     NM_001438222.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2732750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000001.1  191919776-191919832 c
            58-139              JAXUCZ010000001.1  191909096-191909177 c
            140-808             JAXUCZ010000001.1  191907790-191908458 c
            809-2180            JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2180
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..57
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            58..139
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    105..107
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     CDS             129..2021
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 2 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 2"
                     /protein_id="NP_001425151.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEPREGLLTEAMEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPN
                     APRAARHAATHTTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPK
                     AYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAY
                     GTLSKLKIHQRGHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAE
                     LKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLS
                     SYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADL
                     AMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTK
                     HSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVV
                     GEGSAAPVAGAGIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPST
                     LGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSD
                     RAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGM
                     PEEGSA"
     misc_feature    231..293
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    231..293
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(231..233,240..242,279..281,291..293)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(231..233,240..242,279..281,291..293)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    354..1418
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    354..1418
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    417..479
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    417..479
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    501..563
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    501..563
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(501..503,510..512,549..551,561..563)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(501..503,510..512,549..551,561..563)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    585..647
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    585..647
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    669..731
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    669..731
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(669..671,678..680,717..719,729..731)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(669..671,678..680,717..719,729..731)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    753..815
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    753..815
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    837..899
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    837..899
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(837..839,846..848,885..887,897..899)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(837..839,846..848,885..887,897..899)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(852..854,858..860,864..866,870..875,882..887,
                     894..896,936..938,942..944,954..959,966..971,978..980,
                     1020..1022,1026..1028,1032..1034,1038..1043,1050..1055,
                     1062..1064)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(852..854,858..860,864..866,870..875,882..887,
                     894..896,936..938,942..944,954..959,966..971,978..980,
                     1020..1022,1026..1028,1032..1034,1038..1043,1050..1055,
                     1062..1064)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    903..1955
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    903..1955
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    921..983
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    921..983
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1005..1067
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1005..1067
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1089..1151
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1089..1151
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1173..1235
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1173..1235
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1257..1319
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1257..1319
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1341..1403
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1341..1403
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1713..1775
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1713..1775
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1713..1715,1722..1724,1761..1763,1773..1775)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1713..1715,1722..1724,1761..1763,1773..1775)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1728..1730,1734..1736,1740..1742,1746..1751,
                     1758..1763,1770..1772,1812..1814,1818..1820,1830..1835,
                     1842..1847,1854..1856,1896..1898,1902..1904,1908..1910,
                     1914..1919,1926..1931,1938..1940)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1728..1730,1734..1736,1740..1742,1746..1751,
                     1758..1763,1770..1772,1812..1814,1818..1820,1830..1835,
                     1842..1847,1854..1856,1896..1898,1902..1904,1908..1910,
                     1914..1919,1926..1931,1938..1940)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1797..1859
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1797..1859
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1881..1943
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1881..1943
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            140..808
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            809..2180
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagccatg gtatggaaat gcttggtaca ggtcccacaa ctgaagtctc ctgtctggtc
       61 tgcctttcct gagcatttgg agatcttaag gccgcgggtg gacctgagaa aggaatattg
      121 tgagagtaat ggaacctaga gaaggtctac tcaccgaggc catggaagtg gaggctgcag
      181 aggccaagtc cccaggcccc tgctacaagc gctctggccg ccgttataag tgcctgtttt
      241 gtacaaagac atttccaaat gctcccaggg cagcccgcca tgctgctaca catacaacta
      301 cagactgcac agaggaggtg aatgaggtcc agccgaaggt ggatgcagag cccaaggctg
      361 aggaagccag tggagacaag gtatctgggt cagtagccaa gccccggccc tatgcttgcc
      421 ctctgtgccc caaggcctac aagacagctc ctgagctacg cagccatgga cgcagccaca
      481 ctggtgagaa gcccttcccg tgcccagagt gcggccgccg tttcatgcag ccagtgtgcc
      541 tgcgtgtgca cctggcctca cacgctggtg agctgccttt ccgatgcaca cactgcccca
      601 aggcttatgg tacactctct aaactaaaga tccaccagcg tgggcacaca ggcgagcggc
      661 cctatgcctg tactgactgc ggcaagagct ttgctgatcc ttcagtgttc cgcaagcatc
      721 ggcgcacgca tgcaggcctg cgcccctaca gctgcgagcg ctgcggcaag gcctatgctg
      781 agctgaagga cttacgcaac cacgaaaggt cccacacggg tgagcgcccc ttcctctgct
      841 cagagtgtgg taaaagcttc tctcgatcct cttccctcac atgccatcag cgtatccatg
      901 cagcccagaa accctatcgc tgcccggctt gtggtaaggg cttcacacag ctcagctctt
      961 accaaagcca tgagcgcaca cattcaggcg aaaagccctt cctgtgccct cggtgtggcc
     1021 gcatgttctc tgatccctcg agcttccgcc gccaccagcg ggcacatgag ggtgtaaagc
     1081 cttaccgctg tgagaaatgt ggcaaggact tccggcagcc agctgacctg gccatgcacc
     1141 gtcgagtaca caccggcgac cgacccttca agtgcctgca gtgtgacaag acttttgtgg
     1201 cttcctggga cctcaagcgg catgcattgg tacactcagg acagcggccg ttccgctgtg
     1261 aggagtgtgg gcgagcattt gctgagcgag ctagccttac aaagcacagc cgcatgcact
     1321 ctggcgagcg tcctttccac tgtaatgcct gcgggaaatc ctttgtggtg ttatccagcc
     1381 tcaggaagca tgagcgcacc catagaagca acgagactac gggagctgcc ccccagcagg
     1441 agttggtact gggactagca ctgcctgtag gtgtcgtagg tgagggctca gctgcccctg
     1501 tggcaggtgc agggataggg gatgctccag cagggctgct agggttaccg cctgagtctg
     1561 gtagtgtagt ggccacacag tggcaagtgg tgggcatgac tgtagagcat gtggagtgcc
     1621 aggatgctgg cgttggcgaa gctcctagta ccctgggaga tgcaggagag gtgggtgggg
     1681 aggagactga tgagaagccc ccacagtttg tgtgtcgaga gtgcaaagaa actttctcca
     1741 cactgacatt gctacgcagg catgaacgct cacacccaga gctccggccc tttccctgca
     1801 cccagtgtgg taagagcttc tcagacaggg ctgggcttcg taagcatagc cgcacccaca
     1861 gctctgtacg cccctactcc tgttcccaat gtcctaaagc tttcctgagt gccagtgatc
     1921 tgcgcaaaca tgaacgcacc caccctgtgc ccatcgggac ccccataccc ctggaacccc
     1981 ttgtggctct gctaggaatg ccagaagaag ggtcagcctg aagtttatag atctccacta
     2041 cactcccaga aggccatccc tagtctccaa acccctgcct ctgggcagct agctcagttc
     2101 tcgtccacta agagctgtgg acagtggaag ctggtagcat ttgtgagagg tactcattaa
     2161 agcattggct ttgataccaa
//
LOCUS       NM_001438215            3181 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 2, mRNA.
ACCESSION   NM_001438215 XM_017589216
VERSION     NM_001438215.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3181)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_017589216.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.848697.1,
                                           SRR26360194.145388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              JAXUCZ010000001.1  191913797-191914936 c
            1141-1809           JAXUCZ010000001.1  191907790-191908458 c
            1810-3181           JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..3181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3181
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..1140
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1112..1114
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     exon            1141..1809
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             1163..3022
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425144.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    1232..1294
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1232..1294
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1355..2419
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1355..2419
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1418..1480
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1418..1480
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1502..1564
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1502..1564
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1586..1648
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1586..1648
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1670..1732
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1670..1732
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1754..1816
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1754..1816
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1838..1900
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1838..1900
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1853..1855,1859..1861,1865..1867,1871..1876,
                     1883..1888,1895..1897,1937..1939,1943..1945,1955..1960,
                     1967..1972,1979..1981,2021..2023,2027..2029,2033..2035,
                     2039..2044,2051..2056,2063..2065)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1853..1855,1859..1861,1865..1867,1871..1876,
                     1883..1888,1895..1897,1937..1939,1943..1945,1955..1960,
                     1967..1972,1979..1981,2021..2023,2027..2029,2033..2035,
                     2039..2044,2051..2056,2063..2065)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1904..2956
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1904..2956
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1922..1984
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1922..1984
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2006..2068
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2006..2068
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2090..2152
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2090..2152
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2174..2236
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2174..2236
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2258..2320
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2258..2320
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2342..2404
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2342..2404
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2714..2776
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2714..2776
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2729..2731,2735..2737,2741..2743,2747..2752,
                     2759..2764,2771..2773,2813..2815,2819..2821,2831..2836,
                     2843..2848,2855..2857,2897..2899,2903..2905,2909..2911,
                     2915..2920,2927..2932,2939..2941)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2729..2731,2735..2737,2741..2743,2747..2752,
                     2759..2764,2771..2773,2813..2815,2819..2821,2831..2836,
                     2843..2848,2855..2857,2897..2899,2903..2905,2909..2911,
                     2915..2920,2927..2932,2939..2941)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2798..2860
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2798..2860
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2882..2944
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2882..2944
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1810..3181
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcctaaag aacgccattt tgcaggcctt tgtcctgttc tggatcctct gtccattcat
       61 ttcttcagtc cttccttctt cattcattct gtcctgttcc gctcgccgaa gccacgttat
      121 cctagggttt agtcccaaat gagtcagcat acagccccgc tctgcgggag ctgcctgtct
      181 ggcgaggaca cccgcacaaa cacggttgca gagagcgagg aacgctgggt ttctgcaggt
      241 cttgtccctc ctcagagagt ctggtaggcc ctacaccctg caaaatccca tatgcttcag
      301 ggactccatt ccactgaaga aattgaggcc cctagctcta cgcatccctc atttttactg
      361 ctcgttaaat attcttgtgg ggaatggagt attggaagca tgcaagtatc ctcccgtggg
      421 agaaggaaaa cgagggctgg ctcctgggca aaggaaattg catatggagg tggcaaagtt
      481 tgtgaattgt tgatggagct tagactcctg accagagagg acactgctgt agaaactgag
      541 ggtggaaaaa tgggatcatg ttgtgagctg actggttgtt aggcctagga catcattaaa
      601 cgttcaccac aacacaattt catcaattca ccgaaaggct caaggtttgt ggggcttgta
      661 tgttggctta tttgaagctt gtatgtaggt gcctttctta ttgtttcaac cacacctgtg
      721 ctgctcccca aaccaccccg atttaggggg caccgagtct cattaactta aagtaagata
      781 tcattctcct cattgggttt tatcacacag taaacaaatt ggagtactag tgtgatactt
      841 gaaccctgtg accgtgtaag aacggggcat ttcagttaaa tagttggtga ctgactctca
      901 cagactccta tggtggaaga ggcagaggct atagacctcg gcgtgaattc caccagtttg
      961 cttttggtca ccagttttgg aataacaagg gtatagaaca aagttctcag gaccctagtg
     1021 ctggaggtga aaaattaagg cccaaatatt aaaatgtgct agtgctaata aagcagtcgt
     1081 caaggggaca gatggcagaa actttggtat ctgactactt ggcttcaaat accagctgag
     1141 agaaggtcta ctcaccgagg ccatggaagt ggaggctgca gaggccaagt ccccaggccc
     1201 ctgctacaag cgctctggcc gccgttataa gtgcctgttt tgtacaaaga catttccaaa
     1261 tgctcccagg gcagcccgcc atgctgctac acatacaact acagactgca cagaggaggt
     1321 gaatgaggtc cagccgaagg tggatgcaga gcccaaggct gaggaagcca gtggagacaa
     1381 ggtatctggg tcagtagcca agccccggcc ctatgcttgc cctctgtgcc ccaaggccta
     1441 caagacagct cctgagctac gcagccatgg acgcagccac actggtgaga agcccttccc
     1501 gtgcccagag tgcggccgcc gtttcatgca gccagtgtgc ctgcgtgtgc acctggcctc
     1561 acacgctggt gagctgcctt tccgatgcac acactgcccc aaggcttatg gtacactctc
     1621 taaactaaag atccaccagc gtgggcacac aggcgagcgg ccctatgcct gtactgactg
     1681 cggcaagagc tttgctgatc cttcagtgtt ccgcaagcat cggcgcacgc atgcaggcct
     1741 gcgcccctac agctgcgagc gctgcggcaa ggcctatgct gagctgaagg acttacgcaa
     1801 ccacgaaagg tcccacacgg gtgagcgccc cttcctctgc tcagagtgtg gtaaaagctt
     1861 ctctcgatcc tcttccctca catgccatca gcgtatccat gcagcccaga aaccctatcg
     1921 ctgcccggct tgtggtaagg gcttcacaca gctcagctct taccaaagcc atgagcgcac
     1981 acattcaggc gaaaagccct tcctgtgccc tcggtgtggc cgcatgttct ctgatccctc
     2041 gagcttccgc cgccaccagc gggcacatga gggtgtaaag ccttaccgct gtgagaaatg
     2101 tggcaaggac ttccggcagc cagctgacct ggccatgcac cgtcgagtac acaccggcga
     2161 ccgacccttc aagtgcctgc agtgtgacaa gacttttgtg gcttcctggg acctcaagcg
     2221 gcatgcattg gtacactcag gacagcggcc gttccgctgt gaggagtgtg ggcgagcatt
     2281 tgctgagcga gctagcctta caaagcacag ccgcatgcac tctggcgagc gtcctttcca
     2341 ctgtaatgcc tgcgggaaat cctttgtggt gttatccagc ctcaggaagc atgagcgcac
     2401 ccatagaagc aacgagacta cgggagctgc cccccagcag gagttggtac tgggactagc
     2461 actgcctgta ggtgtcgtag gtgagggctc agctgcccct gtggcaggtg cagggatagg
     2521 ggatgctcca gcagggctgc tagggttacc gcctgagtct ggtagtgtag tggccacaca
     2581 gtggcaagtg gtgggcatga ctgtagagca tgtggagtgc caggatgctg gcgttggcga
     2641 agctcctagt accctgggag atgcaggaga ggtgggtggg gaggagactg atgagaagcc
     2701 cccacagttt gtgtgtcgag agtgcaaaga aactttctcc acactgacat tgctacgcag
     2761 gcatgaacgc tcacacccag agctccggcc ctttccctgc acccagtgtg gtaagagctt
     2821 ctcagacagg gctgggcttc gtaagcatag ccgcacccac agctctgtac gcccctactc
     2881 ctgttcccaa tgtcctaaag ctttcctgag tgccagtgat ctgcgcaaac atgaacgcac
     2941 ccaccctgtg cccatcggga cccccatacc cctggaaccc cttgtggctc tgctaggaat
     3001 gccagaagaa gggtcagcct gaagtttata gatctccact acactcccag aaggccatcc
     3061 ctagtctcca aacccctgcc tctgggcagc tagctcagtt ctcgtccact aagagctgtg
     3121 gacagtggaa gctggtagca tttgtgagag gtactcatta aagcattggc tttgatacca
     3181 a
//
LOCUS       NM_001438177            2975 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus cysteinyl-tRNA synthetase 1 (Cars1), transcript
            variant 3, mRNA.
ACCESSION   NM_001438177 XM_039108113
VERSION     NM_001438177.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2975)
  AUTHORS   Liu,C., Gamper,H., Shtivelband,S., Hauenstein,S., Perona,J.J. and
            Hou,Y.M.
  TITLE     Kinetic quality control of anticodon recognition by a eukaryotic
            aminoacyl-tRNA synthetase
  JOURNAL   J Mol Biol 367 (4), 1063-1078 (2007)
   PUBMED   17303165
REFERENCE   2  (bases 1 to 2975)
  AUTHORS   Davidson,E., Caffarella,J., Vitseva,O., Hou,Y.M. and King,M.P.
  TITLE     Isolation of two cDNAs encoding functional human cytoplasmic
            cysteinyl-tRNA synthetase
  JOURNAL   Biol Chem 382 (3), 399-406 (2001)
   PUBMED   11347887
REFERENCE   3  (bases 1 to 2975)
  AUTHORS   Kim,J.E., Kim,K.H., Lee,S.W., Seol,W., Shiba,K. and Kim,S.
  TITLE     An elongation factor-associating domain is inserted into human
            cysteinyl-tRNA synthetase by alternative splicing
  JOURNAL   Nucleic Acids Res 28 (15), 2866-2872 (2000)
   PUBMED   10908348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039108113.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4061.1,
                                           SRR26643298.6168.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000001.1  208225271-208225345 c
            76-167              JAXUCZ010000001.1  208214606-208214697 c
            168-237             JAXUCZ010000001.1  208213181-208213250 c
            238-334             JAXUCZ010000001.1  208212543-208212639 c
            335-433             JAXUCZ010000001.1  208211830-208211928 c
            434-583             JAXUCZ010000001.1  208210555-208210704 c
            584-724             JAXUCZ010000001.1  208203165-208203305 c
            725-813             JAXUCZ010000001.1  208202131-208202219 c
            814-935             JAXUCZ010000001.1  208200700-208200821 c
            936-1048            JAXUCZ010000001.1  208198197-208198309 c
            1049-1177           JAXUCZ010000001.1  208197477-208197605 c
            1178-1307           JAXUCZ010000001.1  208197027-208197156 c
            1308-1411           JAXUCZ010000001.1  208196840-208196943 c
            1412-1509           JAXUCZ010000001.1  208196410-208196507 c
            1510-1699           JAXUCZ010000001.1  208195983-208196172 c
            1700-1768           JAXUCZ010000001.1  208195315-208195383 c
            1769-1850           JAXUCZ010000001.1  208191756-208191837 c
            1851-1931           JAXUCZ010000001.1  208188271-208188351 c
            1932-1999           JAXUCZ010000001.1  208187401-208187468 c
            2000-2059           JAXUCZ010000001.1  208185304-208185363 c
            2060-2143           JAXUCZ010000001.1  208184784-208184867 c
            2144-2975           JAXUCZ010000001.1  208183092-208183923 c
FEATURES             Location/Qualifiers
     source          1..2975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2975
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA synthetase 1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
     exon            1..75
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            76..167
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    149..151
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="upstream in-frame stop codon"
     exon            168..237
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2278
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /EC_number="6.1.1.16"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cysteinyl-tRNA synthetase, cytoplasmic; cysteine--tRNA
                     ligase, cytoplasmic"
                     /codon_start=1
                     /product="cysteine--tRNA ligase, cytoplasmic isoform 3"
                     /protein_id="NP_001425106.1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
                     /translation="MGHARSYISFDILRRVLRDYFQYDVFYCMNITDIDDKIIRRARQ
                     NYLFEQYREQKPSAAQLLKDVGDAMKPFSVKLSETTDPDKRQMLERIQNSVKLATEPL
                     EQAVHSNPSGEEVDSRVQVLLEEAKDLLSDWLDSTGGSEVTDNSIFSKLPKFWEEEFH
                     KDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSVYFDTAKFAASEKHS
                     YGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSWPCPWGKG
                     RPGWHIECSAMAGSLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTG
                     HLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYE
                     KFMNEFFLNVKDILRAPVDITGQFEKWEAEEVELNKNFYDKKTAVHEALCDNIDTRTV
                     MEEMRALVSQCNLYMAARKAARRRPNRALLENIAMYLTHMLKIFGAIEEENPLGFPVG
                     GPGTNLNLESTVMPYLQVLSEFREGVRKIAREKKVLEVLQLSDALRDDILPELGVRFE
                     DHEGLPTVVKLVDRDTLLKEKEEKKRAEEEKRRKKEEAARKKQEQEAAKLAKMKTPPS
                     EMFRSETDKYSKFDENGLPTHDTEGKELSKGQTKKLKKLFEAQEKVYKEYLQQLQNSS
                     LQ"
     misc_feature    224..2266
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     misc_feature    224..2266
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     exon            238..334
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            335..433
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            434..583
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            584..724
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            725..813
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            814..935
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1048
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1177
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1307
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1411
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1509
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1699
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1768
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1850
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1931
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..1999
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2059
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2143
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2975
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattctgga aagcgtctgt ggcggcagac gcgggtcttg attcccagtg atggcaggtt
       61 cctccgcgga gcagggtaaa ggccggcgag tgcagcctca gtggtcccct ccagcaggga
      121 ctgagccctg ccggctccgc ctatacaata gcctcacccg gaacaagatg ggaagaaggt
      181 gacgtggtac tgttgcgggc cgactgtcta tgatgcgtct cacatgggac atgccaggtc
      241 ctacatctct ttcgatatcc tgcggagggt gctgagggat tacttccagt atgatgtctt
      301 ttactgcatg aacatcacag acattgatga taagatcatc aggagggcgc ggcagaacta
      361 cctgtttgag cagtatcggg agcagaaacc ttcggctgcc cagcttctga aggatgttgg
      421 tgatgccatg aagccattct cagtcaagtt aagtgagaca acagaccctg acaagaggca
      481 gatgctggag aggatccaga actctgtgaa gcttgccaca gaaccactgg aacaggctgt
      541 gcattccaac ccctctggag aggaagtaga cagccgtgta caggtgttgc tggaggaagc
      601 aaaggacttg ctctctgact ggctggattc tacaggtggc agtgaggtga ctgacaactc
      661 tattttctcc aaactgccca agttctggga agaagagttc cacaaagaca tggaagccct
      721 gaatgttctc cctcctgatg tcctgacccg tgtcagtgaa tatgtgccgg aaattgtgaa
      781 cttcgtccag aagattgtgg acaacggtta tggctatgct tcaaatgggt ctgtctactt
      841 cgacacagcc aagttcgctg ctagtgaaaa gcactcctat ggcaagctgg tgcctgaggc
      901 tgttggggat cagaaagcac ttcaggaagg ggaaggtgat ctgagcatct ctgctgaccg
      961 ccttagtgag aaacgctctc ccaatgactt cgccttgtgg aaggcctcca agccaggaga
     1021 gccatcctgg ccttgcccct ggggaaaggg tcgtccagga tggcacatag agtgctccgc
     1081 tatggcaggc tcgctcctgg gagcctcaat ggacattcat ggtggaggct ttgacctccg
     1141 cttcccccac catgacaatg agctggcaca gtcagaggcc tactttgaga atgactgctg
     1201 ggtcaggtac ttcttgcaca cgggccactt gacaatagca ggctgcaaga tgtccaagtc
     1261 actgaaaaac ttcatcacca tcaaagatgc cttgaagaag cactcagcac ggcagctgcg
     1321 gctggctttc ctcatgcact cctggaaaga cacactggac tattccagca acactatgga
     1381 gtctgcactt cagtatgaaa agttcatgaa tgaatttttc ttaaacgtga aagacatcct
     1441 ccgagcccct gtggacatca ctggccagtt tgaaaagtgg gaagccgaag aagtggagct
     1501 caataagaac ttctatgaca agaagaccgc agttcatgaa gccctgtgtg ataacattga
     1561 cacccgtact gtcatggagg agatgcgggc tttggtcagt cagtgcaacc tctacatggc
     1621 agccaggaag gccgcaagga ggaggcccaa cagggctctg ctggaaaaca ttgccatgta
     1681 cctcacccac atgctgaaga tctttggagc catagaggag gagaaccccc tgggtttccc
     1741 ggttggtggg cctggaacca acctgaatct cgagtctaca gtcatgccct acctgcaggt
     1801 attatcggaa ttcagggagg gtgtgcgaaa gattgcccga gagaaaaaag tccttgaggt
     1861 tctgcagctc agtgatgccc tccgggatga catcctgcct gagcttgggg tgcggtttga
     1921 agaccacgaa ggactgccaa cagtggtgaa gttggtggac agagacacct tactgaaaga
     1981 gaaggaagaa aagaaaaggg ctgaagaaga gaagaggagg aagaaagagg aggcggccag
     2041 gaagaaacag gagcaagaag cagcaaagct ggccaagatg aagacgccac ccagtgagat
     2101 gttccgctca gaaaccgaca agtattctaa gtttgatgaa aatggtctgc ctacccacga
     2161 cactgaaggc aaagagctga gcaagggcca gaccaagaag ttgaagaagc tctttgaagc
     2221 tcaggagaaa gtgtacaagg agtatctgca acagttgcag aatagcagcc tccagtgata
     2281 ccaccgcagc ccagaagggg tccctgccag cctggccgac atggactagg ccacacggct
     2341 caggcccgcc ctcatcatgt ttacagctgc tctcacacct gaatcaggca gagtggtagc
     2401 agctctggga cactggtaat aaattcttct gaaccaccgg caaggcccgg tctgccctct
     2461 cagcactggg gcgagctggc ctacaggtgc ctgctcagca gcttgggact taggcctcct
     2521 ggtcagttga gccccttcag ccagcctgcc ggaggaattt ccctcacatc ggcgggccga
     2581 gctaatctct gctgtgttgg cacgtttggt ggtattggag taggaaaaag gccgactcag
     2641 cccaacggat ccccctgagc cccagacaaa agccactcag ttgtctgtct ggctctgatg
     2701 aacacacact gcaggtttcc cagagcaact gacaaagtgg cagcaggaca gttgccctgt
     2761 gggatggggc tctggcaagc tgcctgcgac tgccgttatg acagcaagcc cagatcagca
     2821 ccacggcttg taagataagg gattctctag tccaacctga agtgtttctc ctctccacct
     2881 gctcctgcct gtttgttcgc ccttgccaag aatcagcacc tatgctgaat gtgtctagcc
     2941 ttctctaatg attaaaaaga aaagaaagaa aggta
//
LOCUS       NM_001438193            2669 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 3, mRNA.
ACCESSION   NM_001438193 XM_006229761
VERSION     NM_001438193.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229761.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.3231.1,
                                           SRR26643291.2192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000001.1  162082536-162082764 c
            230-2669            JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2669
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..229
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="upstream in-frame stop codon"
     exon            230..2669
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1299
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425122.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     238..288
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     289..1296
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    415..477
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    424..495
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    424..495
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    460..462
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <490..>1155
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <490..>1155
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    493..558
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    505..567
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    505..567
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    565..630
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    568..636
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    568..636
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    634..699
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    637..714
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    637..714
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    649..651
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    715..795
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    715..795
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    715..777
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    793..858
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    796..852
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    796..852
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    808..810
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    859..930
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    859..930
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    859..921
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    928..996
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    931..1005
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    931..1005
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1003..1068
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    1006..1080
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1006..1080
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1078..1143
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    1081..1152
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1081..1152
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtg ggtgctgtcc
       61 cgaagcgcag cgagatcggc gccggtttgg aggtttggag cccgggactt caacctcacc
      121 gccccatcct gtgagcaggc cggtgcgagg ggcgggtccg ggtcctgctg aggcccctca
      181 acttttccgg gacacggagc cacagcggcg cagggtccgg ggagcagggg tgtcaccatg
      241 ttgtgcaccc tgttcctgct actgctggcc ctgggcacag tgcagacaac tcggccatgt
      301 ttccctggct gccagtgtga ggaagagacg tttggcctct ttgacagttt cagcctgatc
      361 cgagtggact gcagcagcct gggcccccac attgtgcctg tgcccatccc tctggacaca
      421 gcccacctgg acctgtcttc caaccggcta gaaaccgtga atgagtcagt cctgggaggg
      481 ccaggctata ccacactggc tggcctggat ctcagtcaca acctcctcac cagcatcacg
      541 cccactgcct tctcccgcct tcgctacctg gagtcactgg acctcagtca caatggcctg
      601 gcagccctgc cagcagaggt tttcaccagc tcccccttga gtgatatcaa cctgagccat
      661 aatcgactta gagaggtctc aatatctgcc ttcaccaccc acagccaggg gcgggcactg
      721 cacgtggacc tatcccacaa tcttatccac cgcctgctcc cctatccagc cagggccagc
      781 ctgtccgcac ctaccattca gagcctgaac ctgtcctgga accggctccg agccgtgccc
      841 aatctccgag acctacccct gcgttacctg agcctggatg ggaaccctct ggctaccatc
      901 aacccaggcg ccttcatggg gctggcgggc ctcacccacc tttcactggc aagcctacag
      961 ggtatcctcc agctaccacc ccatggcttc cgagagctcc caggccttca ggtcctggac
     1021 ttgtctggta accccaagct caagtgggca ggagccgagg tattttcagg cctgggtttg
     1081 ctgcaagaac tagacctgtc tggctccagc ctggtgcccc tgcctgagac gctgctacat
     1141 cacctccctg ctttacagag tgtcagtgta ggccaagatg tgcagtgccg gcgtctggta
     1201 cgggagggtg cctaccaccg ccaacccggt tccagcccta aggtagtcct gcactgtgga
     1261 gacacccagg aatctgccag gggcccagac atcttgtgac gaatggtgtg gcctgaggcc
     1321 acttgacaga ctgctgtcct gggcttgctc aggtccccac taatatttta atgtgccaat
     1381 gcctgtggag tgtctacagg tctaagtggc agccatctca gtgaagatgt gggccaagga
     1441 tagttttcat acctagggcc tatacccaat aacagaatct gcccgcttgt ctcagcggct
     1501 cacttccctg agctatgagc aaagggactt cgatgccaaa ccagactttg gtcccttcct
     1561 gagccctgcc ccagttatct ctaagtgcct tcccttttgc ccagactgac ctgacccatg
     1621 atgtaaggac cgtaggggag caccaccact gcaaaggctg actaaggtct gttgggctaa
     1681 aggtctcttt gagcccagtg tctatagtca caccttcttt gctctgggcc caggaggcct
     1741 acttcttctt tttctcgtgg aatcctggaa tcttaaagat aaaagaacct agaaagaaaa
     1801 tcaaacccat tttccttgtg gggcagatgg taatatggga ctgagaacag caaacctggg
     1861 gtcttggaga ggagcccagc ctcctgttga ggttgagagc tctgtcaccc tcccttcccc
     1921 tgctgggtac cctgttacta ttgtctgtac tgttttccat tgtgcccagc agtagcaaca
     1981 acaaggtcac agaggtggga actctaggtc cagtggccag cttatggtgt gagcgtagtc
     2041 agtccccctt tcagagcctc aggaagcttg gagcacctca gtctcaagcc tgtcagttcc
     2101 ttactctggg atgaccccca acatcaagac tggaaacata cacattctcc ccagggacac
     2161 agtcttaaga tgcttttcta agaagtcaat gcagttgtga ccatgtggcc atgagctcca
     2221 agggactcgt gggcttggtg tccatgggcc ggagcccaaa gacccgcttc cccctccaag
     2281 agtatggcag aaagggtctc ccatgcacat tgtgctcccc gccagggcca catctcagct
     2341 ctccagctct ggattctttc ttctgttttc attttatgag tcgttgtctt ttttaaaatg
     2401 aactgtttaa cccccacctc tgctggccag gggatggaaa ggaagataaa tgtatttgtt
     2461 cgcttttgta agactctgtt ctgggtgtgg gctggggatc ttgggaagaa gccagttggc
     2521 tatcagtaac catgtgggca ttggggctgg tccctgggat gctcaaaagt cagtgagagc
     2581 tctgtcttct cacactagcc cagcccagcc caccccgtga ctggtccttg gtttaataaa
     2641 cacatgtaag agctctttcc atcactgga
//
LOCUS       NM_001438184            4001 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus taxilin beta (Txlnb), transcript variant 2, mRNA.
ACCESSION   NM_001438184 XM_039112431
VERSION     NM_001438184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_039112431.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.88.1, SRR26643295.108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000001.1  14225883-14225993
            112-557             JAXUCZ010000001.1  14227624-14228069
            558-649             JAXUCZ010000001.1  14235494-14235585
            650-820             JAXUCZ010000001.1  14241775-14241945
            821-1015            JAXUCZ010000001.1  14250713-14250907
            1016-1135           JAXUCZ010000001.1  14252937-14253056
            1136-1210           JAXUCZ010000001.1  14257014-14257088
            1211-1303           JAXUCZ010000001.1  14262873-14262965
            1304-1399           JAXUCZ010000001.1  14265928-14266023
            1400-4001           JAXUCZ010000001.1  14267236-14269837
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..4001
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="taxilin beta"
                     /db_xref="GeneID:308622"
                     /db_xref="RGD:1307979"
     exon            1..111
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    44..46
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="upstream in-frame stop codon"
     exon            112..557
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2182
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /codon_start=1
                     /product="beta-taxilin"
                     /protein_id="NP_001425113.1"
                     /db_xref="GeneID:308622"
                     /db_xref="RGD:1307979"
                     /translation="METNHPDQLSVEQPNPPGDSSPLNQNVPGKQDVQQSSTSGQAAE
                     QEASPHPEKGDHDISEELSRQLEDIINMYGSAASPTGKEGTSETKEQPQNTEAPDNED
                     GDYEETTEETDREPTAPEEPATVKGPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQA
                     PEEKLDFLFKKYAELLDEHRTEQKKLKLLLKQQAQTQREKDQLQSEHNRAILARSKLE
                     SLCRELQRHNKTLKEETLQRAREEEEKRKEITSHFQSTLTDIQTQIEQQSERNMKLCQ
                     ENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEEAQELMQEAEERHRRE
                     KEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMD
                     NTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIQRLENLCRAL
                     QEERKELYKKIRDAKMSEKEDQVQHTSDEEPESKVSEDKQMDVEAANGVQNAVKNLAT
                     AFAILHHPEFTPDQSRERQPAVNGPPGGSDLTHQHTEPAHLNHPNPSSVSGSPQPPVG
                     SQAGSEGGCEAAPAPTACCTPAEAELQSQGLSAGNPPDPKPQKPEAKASGQVPLSPAQ
                     GSLAVVEAKCDISPSPESERDPAVVPGCESKEHPPPEVPDIPLGPNTGLPREPDACLN
                     GVE"
     misc_feature    560..1483
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="Myosin-like coiled-coil protein; Region: Taxilin;
                     pfam09728"
                     /db_xref="CDD:462861"
     misc_feature    560..1483
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="Myosin-like coiled-coil protein; Region: Taxilin;
                     pfam09728"
                     /db_xref="CDD:462861"
     misc_feature    <1703..2155
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <1703..2155
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     exon            558..649
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            650..820
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1015
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1135
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1210
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1303
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1399
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..4001
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggatctaaa tcgcagtggt ggagacatcg ccatattttg tgataaccca gcggctggat
       61 taaacgagtg aacttccttc taagtcagcg aaggctgggt gggcgccaca ggtcctgctc
      121 ccatatggag actaatcatc ctgatcagct ctcagtagaa cagccaaatc ccccagggga
      181 tagctctcca ctcaatcaaa acgtcccagg aaaacaagat gttcaacagt cctcaacctc
      241 aggccaagca gcagagcaag aggcaagccc gcatcctgag aagggagacc acgatatctc
      301 tgaagagctg agccgacaac tggaagacat tataaacatg tacgggtctg ctgccagtcc
      361 cacaggaaaa gagggcacct ccgaaactaa ggagcagccc caaaacacag aggcaccgga
      421 caatgaggat ggcgactatg aggaaaccac tgaagagaca gacagagaac ccactgctcc
      481 tgaagagcct gccacagtca aagggcctgt cagtaataaa gagcaaaagc tggaaaagaa
      541 aatcctgaaa ggattaggta aagaagctaa cttgctcatg caaaatctaa acaagctgca
      601 ggcacccgaa gaaaagcttg attttttatt caagaagtat gctgaattgc tggatgaaca
      661 tcgcactgag caaaagaaac tgaagctcct actgaaacag caggcgcaaa cgcagagaga
      721 gaaggaccag ttgcagagtg agcacaacag agccatcctg gctcgaagca aactcgagag
      781 tctgtgtcgg gagctacaga ggcataataa gacactgaag gaagagaccc tccaacgggc
      841 gcgcgaggaa gaagagaaga ggaaagagat cacgagtcat tttcagagta ccctgacaga
      901 tatccagacc cagatagaac agcagagcga gcgcaatatg aagctctgcc aggagaacac
      961 agagctcgca gaaaaactga aaagcatcat cgaccagtac gagctcagag aggagcatct
     1021 ggacaaaata ttcaaacacc gagaactgca gcagaagctg gtggatgcga aacttgaaga
     1081 ggcccaagaa ctgatgcagg aagcagaaga gcggcacaga cgggagaagg aatatttgct
     1141 gaaccaggca gcagagtgga aacttcaggc caaagtgcta aaggagcagg agaccgtgct
     1201 gcaggctcag cttactctct actcgggaag gtttgaggag ttccagagta cactgacaaa
     1261 aagtaatgaa gtgtttgcca ctttcaagca ggaaatggat aatacgacaa agaaaatgaa
     1321 gaagctggag aaggacacgg ccacatggaa agcccgattt gagaattgta acaaagccct
     1381 gctggacatg atcgaagaga aagccctgcg agctaaggaa tacgagtgtt tcgtgatgaa
     1441 aatccagagg ctggagaacc tgtgtcgtgc tttacaagaa gagagaaagg aactctacaa
     1501 gaaaatcaga gacgcaaaaa tgtccgaaaa ggaagaccag gttcagcaca cctctgacga
     1561 agagccagag tcaaaagtct cggaagataa acagatggat gtagaggcag ccaacggcgt
     1621 tcaaaatgct gtgaaaaatc tggccacagc tttcgccatc cttcatcatc cagagttcac
     1681 cccagaccaa tcaagggaaa gacaaccggc agtgaatggc cctccaggtg gaagtgacct
     1741 cacccaccag cataccgaac cagcccattt aaaccatccc aacccttcca gtgtttcagg
     1801 gagtcctcag ccccctgtgg gttctcaggc tggttctgag gggggctgtg aggctgctcc
     1861 tgcccctaca gcctgctgta cccctgcaga ggcagagctc caaagccagg gtctctctgc
     1921 tgggaacccc ccagacccga agccgcagaa gccagaggca aaagcttctg gtcaggtccc
     1981 actgtcccca gcccagggct ccctagccgt agtagaggca aaatgtgata tttcgccgtc
     2041 cccagagagt gagagagatc ctgctgttgt acctgggtgt gagtctaagg aacatccccc
     2101 accagaagtc ccagacatcc cgctaggccc taacaccggg ctccccagag agcccgacgc
     2161 ctgtctgaac ggagtagagt aagcctcatc gattcttctg tctgttcacc tgcagaaaat
     2221 ctgtgaaaga aacttctagt cctagaaaac acatacacac gtattttcat acatgtatat
     2281 aacgttatca tataagcata tttcactcct tacagatttt tctctattgc aagatattta
     2341 catgcttgta aaaaaattct ctctttctta cactctggat tacagtagat taaaactgta
     2401 tgaatcagaa acagcacatg ctgtacacaa ggaggacctc aggacgcctt taacagcaaa
     2461 ggggaaacca caaacaggtg gttctgatct gctaatgctt ctgattctca cagctagctt
     2521 cctcccagct tcccagcatc ccacctcccg ggatgaagca gcctcctcct ggctatctgt
     2581 gagaaagtgg ttggaaataa agaatctaag atttgagggg ttgcgtatac tcagcataga
     2641 ggaagctggc cctggcccct gcttctttgg ctactgattt ctcaggaaaa cacttcttgt
     2701 tgtctctaac cttgtgtttt atctcaaagc atctatttct tccgagttcc ctcctttgtg
     2761 tcaatgtgta tgcctagctc acgtctctat tactgttaag taaaatatat ttttccgaaa
     2821 caggaatcca cacgacctct caataggagt aataaggctt acaaagccaa cacattttct
     2881 gctctaagga gttttgaaca ggcagaaata caaaattaaa aaggggcaga cgaggactcc
     2941 atagatgtca aaagctagaa gcaattggga ttacccaaac aagttttata ctcgcattat
     3001 tgacaaaaaa aaaatcctct actaacactg acagcataca ttactctgcc taggctaaaa
     3061 gaagactata ctaacaaaac aggaagaagt gggaaggagg gagacagaag gagtataagg
     3121 aatggactgt ctaatctaac tctacgttaa gaagttgaac acaggtagaa atatggatga
     3181 aggaaggctc ttgaaaactc atccaggaag tcattcttca gtggtgcatg gtggctgttt
     3241 gccaatgcac ataaggagct ggtaggcagt agccatatgt taaaggaatt ataaaactgt
     3301 ataaaatttg tttgaagtag acagtaaggg aaagaacaaa aataccattt ggggaataaa
     3361 aaaaaaaaaa aaaccagggg aaaaagcacg tcgttatttg agaactcatg tgttttcaga
     3421 ggctttgcat attataaccg cacgggtatc cagccaagtt caacaccact ggaaattaga
     3481 cattcaatta actcaaagtc aaatattcac tatactaatc ccttctctct gtttacagga
     3541 gaaaggacag agtaggatca tcacagttaa gtctcaatcc aaaaactcag gaagacaaac
     3601 aggcaggagg cactgacatc caataaatta ggaattctaa tatccaatgt ttattatttt
     3661 catccaagag aatttcacag caacatatca ctcataactg tgtgtacctt tggcacagtt
     3721 tcataggcta taccttccct gaaacctgta aagctttaat ataggctttg ggagacttat
     3781 tttaatagtc aaagaatgtt ttattatagt actttgtgtt caaacttggc cttactaatc
     3841 ataacaactc ataagatctg aaagcagaaa ttacatctct tctttatgaa gttcatataa
     3901 ctatttttag agatgccaaa tctttctaga aacactggaa ttattgcttt ctaaatgtaa
     3961 taacataatg tttataccaa ttaaaaaggc atttcttcca a
//
LOCUS       NM_001438221            2692 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 8, mRNA.
ACCESSION   NM_001438221
VERSION     NM_001438221.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.570534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               JAXUCZ010000001.1  191921720-191922137 c
            419-569             JAXUCZ010000001.1  191909397-191909547 c
            570-651             JAXUCZ010000001.1  191909096-191909177 c
            652-1320            JAXUCZ010000001.1  191907790-191908458 c
            1321-2692           JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2692
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..418
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            419..569
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            570..651
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    617..619
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="upstream in-frame stop codon"
     CDS             641..2533
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 2 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 2"
                     /protein_id="NP_001425150.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEPREGLLTEAMEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPN
                     APRAARHAATHTTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPK
                     AYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAY
                     GTLSKLKIHQRGHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAE
                     LKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLS
                     SYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADL
                     AMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTK
                     HSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVV
                     GEGSAAPVAGAGIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPST
                     LGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSD
                     RAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGM
                     PEEGSA"
     misc_feature    743..805
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    743..805
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(743..745,752..754,791..793,803..805)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(743..745,752..754,791..793,803..805)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    866..1930
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    866..1930
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    929..991
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    929..991
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1013..1075
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1013..1075
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1013..1015,1022..1024,1061..1063,1073..1075)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1013..1015,1022..1024,1061..1063,1073..1075)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1097..1159
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1097..1159
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1181..1243
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1181..1243
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1181..1183,1190..1192,1229..1231,1241..1243)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1181..1183,1190..1192,1229..1231,1241..1243)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1265..1327
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1265..1327
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1349..1411
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1349..1411
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1349..1351,1358..1360,1397..1399,1409..1411)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1349..1351,1358..1360,1397..1399,1409..1411)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1364..1366,1370..1372,1376..1378,1382..1387,
                     1394..1399,1406..1408,1448..1450,1454..1456,1466..1471,
                     1478..1483,1490..1492,1532..1534,1538..1540,1544..1546,
                     1550..1555,1562..1567,1574..1576)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1364..1366,1370..1372,1376..1378,1382..1387,
                     1394..1399,1406..1408,1448..1450,1454..1456,1466..1471,
                     1478..1483,1490..1492,1532..1534,1538..1540,1544..1546,
                     1550..1555,1562..1567,1574..1576)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1415..2467
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1415..2467
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1433..1495
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1433..1495
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1517..1579
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1517..1579
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1601..1663
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1601..1663
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1685..1747
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1685..1747
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1769..1831
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1769..1831
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1853..1915
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1853..1915
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2225..2287
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2225..2287
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2225..2227,2234..2236,2273..2275,2285..2287)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2225..2227,2234..2236,2273..2275,2285..2287)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2240..2242,2246..2248,2252..2254,2258..2263,
                     2270..2275,2282..2284,2324..2326,2330..2332,2342..2347,
                     2354..2359,2366..2368,2408..2410,2414..2416,2420..2422,
                     2426..2431,2438..2443,2450..2452)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2240..2242,2246..2248,2252..2254,2258..2263,
                     2270..2275,2282..2284,2324..2326,2330..2332,2342..2347,
                     2354..2359,2366..2368,2408..2410,2414..2416,2420..2422,
                     2426..2431,2438..2443,2450..2452)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2309..2371
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2309..2371
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2393..2455
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2393..2455
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            652..1320
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..2692
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctgaaca ttctggtcta ccgggactgt gctccccagg cctcttgact tcatgctcta
       61 gtactgactc aatatcatct gacctgccct ccagccccca gtcatcaagg tcctccttac
      121 tgtcttctgt accatgttgg cctccctggc cactggccag ctctagtttg ctctcctcat
      181 gttcccgtag atgttgctct agagatccct ggccagaaaa gccacagcca caaagggcac
      241 aatgtatagc tgctgtcttc tggggccatc ctgactgtcg ccgccgttga ctatcagaat
      301 gcagcctctg atggtctttc agggctttgc ggttggaata ggtcttaaaa cagaaagggc
      361 agctgtaacg gcctgtctca tggttgcatt ggtggttcag gaggctgcca gcatggcgga
      421 gcagctgtgt ggatgttgtc tgggctcttg gccagaaagt agagcctctg caagagccag
      481 taccccagga ggcctcccta gctcagacac atcagttgtg actgactgaa gaggctcgac
      541 tgtcagcagt aggtcaggct gctttgagag tctgcctttc ctgagcattt ggagatctta
      601 aggccgcggg tggacctgag aaaggaatat tgtgagagta atggaaccta gagaaggtct
      661 actcaccgag gccatggaag tggaggctgc agaggccaag tccccaggcc cctgctacaa
      721 gcgctctggc cgccgttata agtgcctgtt ttgtacaaag acatttccaa atgctcccag
      781 ggcagcccgc catgctgcta cacatacaac tacagactgc acagaggagg tgaatgaggt
      841 ccagccgaag gtggatgcag agcccaaggc tgaggaagcc agtggagaca aggtatctgg
      901 gtcagtagcc aagccccggc cctatgcttg ccctctgtgc cccaaggcct acaagacagc
      961 tcctgagcta cgcagccatg gacgcagcca cactggtgag aagcccttcc cgtgcccaga
     1021 gtgcggccgc cgtttcatgc agccagtgtg cctgcgtgtg cacctggcct cacacgctgg
     1081 tgagctgcct ttccgatgca cacactgccc caaggcttat ggtacactct ctaaactaaa
     1141 gatccaccag cgtgggcaca caggcgagcg gccctatgcc tgtactgact gcggcaagag
     1201 ctttgctgat ccttcagtgt tccgcaagca tcggcgcacg catgcaggcc tgcgccccta
     1261 cagctgcgag cgctgcggca aggcctatgc tgagctgaag gacttacgca accacgaaag
     1321 gtcccacacg ggtgagcgcc ccttcctctg ctcagagtgt ggtaaaagct tctctcgatc
     1381 ctcttccctc acatgccatc agcgtatcca tgcagcccag aaaccctatc gctgcccggc
     1441 ttgtggtaag ggcttcacac agctcagctc ttaccaaagc catgagcgca cacattcagg
     1501 cgaaaagccc ttcctgtgcc ctcggtgtgg ccgcatgttc tctgatccct cgagcttccg
     1561 ccgccaccag cgggcacatg agggtgtaaa gccttaccgc tgtgagaaat gtggcaagga
     1621 cttccggcag ccagctgacc tggccatgca ccgtcgagta cacaccggcg accgaccctt
     1681 caagtgcctg cagtgtgaca agacttttgt ggcttcctgg gacctcaagc ggcatgcatt
     1741 ggtacactca ggacagcggc cgttccgctg tgaggagtgt gggcgagcat ttgctgagcg
     1801 agctagcctt acaaagcaca gccgcatgca ctctggcgag cgtcctttcc actgtaatgc
     1861 ctgcgggaaa tcctttgtgg tgttatccag cctcaggaag catgagcgca cccatagaag
     1921 caacgagact acgggagctg ccccccagca ggagttggta ctgggactag cactgcctgt
     1981 aggtgtcgta ggtgagggct cagctgcccc tgtggcaggt gcagggatag gggatgctcc
     2041 agcagggctg ctagggttac cgcctgagtc tggtagtgta gtggccacac agtggcaagt
     2101 ggtgggcatg actgtagagc atgtggagtg ccaggatgct ggcgttggcg aagctcctag
     2161 taccctggga gatgcaggag aggtgggtgg ggaggagact gatgagaagc ccccacagtt
     2221 tgtgtgtcga gagtgcaaag aaactttctc cacactgaca ttgctacgca ggcatgaacg
     2281 ctcacaccca gagctccggc cctttccctg cacccagtgt ggtaagagct tctcagacag
     2341 ggctgggctt cgtaagcata gccgcaccca cagctctgta cgcccctact cctgttccca
     2401 atgtcctaaa gctttcctga gtgccagtga tctgcgcaaa catgaacgca cccaccctgt
     2461 gcccatcggg acccccatac ccctggaacc ccttgtggct ctgctaggaa tgccagaaga
     2521 agggtcagcc tgaagtttat agatctccac tacactccca gaaggccatc cctagtctcc
     2581 aaacccctgc ctctgggcag ctagctcagt tctcgtccac taagagctgt ggacagtgga
     2641 agctggtagc atttgtgaga ggtactcatt aaagcattgg ctttgatacc aa
//
LOCUS       NR_199373               1168 bp    RNA     linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus proline rich and Gla domain 2 (Prrg2), transcript
            variant 4, non-coding RNA.
ACCESSION   NR_199373
VERSION     NR_199373.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2844146.1,
                                           SRR22399484.2501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  104679769-104679813 c
            46-110              JAXUCZ010000001.1  104678978-104679042 c
            111-264             JAXUCZ010000001.1  104678247-104678400 c
            265-304             JAXUCZ010000001.1  104677511-104677550 c
            305-446             JAXUCZ010000001.1  104673619-104673760 c
            447-575             JAXUCZ010000001.1  104671671-104671799 c
            576-1168            JAXUCZ010000001.1  104670748-104671340 c
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1168
                     /gene="Prrg2"
                     /note="proline rich and Gla domain 2"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     misc_RNA        1..1168
                     /gene="Prrg2"
                     /product="proline rich and Gla domain 2, transcript
                     variant 4"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     exon            1..45
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..110
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..264
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            265..304
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..446
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..575
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1168
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaataact ctgcccctag ttgtggaggc gcttctcctc tcttgctggc tactgctaac
       61 ccagagggtc ttcattcaag aagagaagca ggcctcccag ccctggacag agtctgggca
      121 gggagtcctg gggcctcata actctgctga ggcatttgtc atctgggagt tcacacaata
      181 tgaggagcca tccttccctg ctcttagtct acatgggatt ggccacctgc ctggacacct
      241 tacctcatag agagcaaagc caaggagcgt ttctgggaaa gctatgcata caacggcaag
      301 ggagggcgtg gacgggtgga tgttgcaggc ctggcagtgg gactgacctc tgggatcctg
      361 ctcatcgtgt tggctggctt gggagccttt tggtatctgc attatcgacg gcgccgcctc
      421 agagtccagg agtcctgtct gcaagagacc gggctcatca tccccttaag tcctccgacg
      481 cctctgtctc caccgcctcc cccaggcctt cccacctatg agcaggcttt agcagcctcc
      541 ggggtgcacg acgcccctcc acccccttac tccagcctca gaaggcccca ctgaagacct
      601 gctccgagcg cgggctccct caactgtgcc cctgattcat agcggattcc ggaagtcgcc
      661 ggcttcttcg acgactaggc ttcagtgtgt ccgtggggga gtcggggtcg tcggacccgg
      721 ggtctacatg acacacgtgt ttccgccggg cacgcataca cgcatgtccc tgaccatcct
      781 gttgccgagt cggtgcccct ggcccgcgcg tgaaccccca cttctgctga gccttgcctc
      841 agaatggaca gactttttag gaaactcgga ccagacgtga ctcggctgtc accccactgg
      901 tgccgcggag cgcgtacact cagggaacca ggcccttaca cacgccttac ttggtgtatt
      961 tccccactcg tgcacatggg cggttcgtaa tccagcataa agatgggggg cacatttgca
     1021 atgtgctgta agtggggtgt caacgcttgt gttgcacccg ggtaaatgga gttgatctga
     1081 gctgcccttt acttaaaaac cctttgggaa aagggtggaa gaaattaaaa ttgaaacaat
     1141 aagaaaaata aaaatgcaaa agaactga
//
LOCUS       NR_199375                562 bp    RNA     linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus adipogenesis associated, Mth938 domain containing
            (Aamdc), transcript variant 3, non-coding RNA.
ACCESSION   NR_199375
VERSION     NR_199375.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 562)
  AUTHORS   Ma,X., Ding,W., Wang,J., Wu,G., Zhang,H., Yin,J., Zhou,L. and Li,D.
  TITLE     LOC66273 isoform 2, a novel protein highly expressed in white
            adipose tissue, induces adipogenesis in 3T3-L1 cells
  JOURNAL   J Nutr 142 (3), 448-455 (2012)
   PUBMED   22279136
REFERENCE   2  (bases 1 to 562)
  AUTHORS   Wang,H., Ma,X., Zhang,H., Zang,J., Hu,S. and Li,D.
  TITLE     Involvement of LOC66273 isoform 2, a novel Mth938 containing
            protein, in MAPK pathway
  JOURNAL   Front Biosci (Elite Ed) 3 (4), 1241-1248 (2011)
   PUBMED   21622130
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE109377.1, SRR26360194.490274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840121 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  161303116-161303192 c
            78-173              JAXUCZ010000001.1  161281014-161281109 c
            174-562             JAXUCZ010000001.1  161273216-161273604 c
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..562
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="adipogenesis associated, Mth938 domain containing"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     misc_RNA        1..562
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /product="adipogenesis associated, Mth938 domain
                     containing, transcript variant 3"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     exon            1..77
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            78..173
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..314
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="COORDINATES: ab initio prediction:ORF Finder"
                     /note="predicted ORF does not meet quality criteria for
                     protein coding locus with longer protein data"
     exon            174..562
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatctctc agctagctgc agggagaggt agagcgcgga gccgactgga ggagcaaccg
       61 aagaacagaa gcgctgccat tctcctggag tgcagccagc agacgtaaag gaagttgctg
      121 agaagggtgt acagactctt gtgattggca gaggaatgag cgaggccttg aaggtgcctc
      181 catcgactgt ggagtacctc gagaaacaag gcattgatgt gcgagtcctc cagacagagc
      241 aggcagtgaa ggagtacaat gccttggctg cccgggggat aagggtagga ggtgtcttcc
      301 attccacctg ctgatggagc ctacagagga gaataaacct ctgggcagca atgccttacc
      361 atctccacat cagcctcctc tgtgtacttt ggacacatgt tcatgttctt ggaacagatt
      421 gatgggaggc taaggcaaag ttcttgccct ccaggttgct taaatcagaa gagagatttg
      481 ctgattttag tattgtacta tgtgttcggt tcaaagtatg agaaagttca tacaaaaata
      541 aaggttgaag cttagaagcc aa
//
LOCUS       NR_199376                611 bp    RNA     linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus adipogenesis associated, Mth938 domain containing
            (Aamdc), transcript variant 4, non-coding RNA.
ACCESSION   NR_199376
VERSION     NR_199376.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Ma,X., Ding,W., Wang,J., Wu,G., Zhang,H., Yin,J., Zhou,L. and Li,D.
  TITLE     LOC66273 isoform 2, a novel protein highly expressed in white
            adipose tissue, induces adipogenesis in 3T3-L1 cells
  JOURNAL   J Nutr 142 (3), 448-455 (2012)
   PUBMED   22279136
REFERENCE   2  (bases 1 to 611)
  AUTHORS   Wang,H., Ma,X., Zhang,H., Zang,J., Hu,S. and Li,D.
  TITLE     Involvement of LOC66273 isoform 2, a novel Mth938 containing
            protein, in MAPK pathway
  JOURNAL   Front Biosci (Elite Ed) 3 (4), 1241-1248 (2011)
   PUBMED   21622130
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.191172.1,
                                           SRR22399492.2287322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  161303116-161303192 c
            78-126              JAXUCZ010000001.1  161301714-161301762 c
            127-222             JAXUCZ010000001.1  161281014-161281109 c
            223-611             JAXUCZ010000001.1  161273216-161273604 c
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..611
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="adipogenesis associated, Mth938 domain containing"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     misc_RNA        1..611
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /product="adipogenesis associated, Mth938 domain
                     containing, transcript variant 4"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     exon            1..77
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            78..126
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            127..222
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    205..363
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="COORDINATES: ab initio prediction:ORF Finder"
                     /note="predicted ORF does not meet quality criteria for
                     protein coding locus with longer protein data"
     exon            223..611
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatctctc agctagctgc agggagaggt agagcgcgga gccgactgga ggagcaaccg
       61 aagaacagaa gcgctgcgtg gcaaaggcag gaagaacacc gagttcaggc cagctagggc
      121 tataagcatt ctcctggagt gcagccagca gacgtaaagg aagttgctga gaagggtgta
      181 cagactcttg tgattggcag aggaatgagc gaggccttga aggtgcctcc atcgactgtg
      241 gagtacctcg agaaacaagg cattgatgtg cgagtcctcc agacagagca ggcagtgaag
      301 gagtacaatg ccttggctgc ccgggggata agggtaggag gtgtcttcca ttccacctgc
      361 tgatggagcc tacagaggag aataaacctc tgggcagcaa tgccttacca tctccacatc
      421 agcctcctct gtgtactttg gacacatgtt catgttcttg gaacagattg atgggaggct
      481 aaggcaaagt tcttgccctc caggttgctt aaatcagaag agagatttgc tgattttagt
      541 attgtactat gtgttcggtt caaagtatga gaaagttcat acaaaaataa aggttgaagc
      601 ttagaagcca a
//
LOCUS       NR_199374               1201 bp    RNA     linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus proline rich and Gla domain 2 (Prrg2), transcript
            variant 5, non-coding RNA.
ACCESSION   NR_199374
VERSION     NR_199374.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.729491.1,
                                           SRR26360172.1909452.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000001.1  104678978-104679120 c
            144-297             JAXUCZ010000001.1  104678247-104678400 c
            298-337             JAXUCZ010000001.1  104677511-104677550 c
            338-479             JAXUCZ010000001.1  104673619-104673760 c
            480-608             JAXUCZ010000001.1  104671671-104671799 c
            609-1201            JAXUCZ010000001.1  104670748-104671340 c
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1201
                     /gene="Prrg2"
                     /note="proline rich and Gla domain 2"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     misc_RNA        1..1201
                     /gene="Prrg2"
                     /product="proline rich and Gla domain 2, transcript
                     variant 5"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     exon            1..143
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..297
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..337
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..479
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..608
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1201
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggatcg ggcctagtac cagaggtgga gcacccctcc tccttctccc ctcccctctc
       61 ccttacccct ttgcacagct ggctactgct aacccagagg gtcttcattc aagaagagaa
      121 gcaggcctcc cagccctgga cagagtctgg gcagggagtc ctggggcctc ataactctgc
      181 tgaggcattt gtcatctggg agttcacaca atatgaggag ccatccttcc ctgctcttag
      241 tctacatggg attggccacc tgcctggaca ccttacctca tagagagcaa agccaaggag
      301 cgtttctggg aaagctatgc atacaacggc aagggagggc gtggacgggt ggatgttgca
      361 ggcctggcag tgggactgac ctctgggatc ctgctcatcg tgttggctgg cttgggagcc
      421 ttttggtatc tgcattatcg acggcgccgc ctcagagtcc aggagtcctg tctgcaagag
      481 accgggctca tcatcccctt aagtcctccg acgcctctgt ctccaccgcc tcccccaggc
      541 cttcccacct atgagcaggc tttagcagcc tccggggtgc acgacgcccc tccaccccct
      601 tactccagcc tcagaaggcc ccactgaaga cctgctccga gcgcgggctc cctcaactgt
      661 gcccctgatt catagcggat tccggaagtc gccggcttct tcgacgacta ggcttcagtg
      721 tgtccgtggg ggagtcgggg tcgtcggacc cggggtctac atgacacacg tgtttccgcc
      781 gggcacgcat acacgcatgt ccctgaccat cctgttgccg agtcggtgcc cctggcccgc
      841 gcgtgaaccc ccacttctgc tgagccttgc ctcagaatgg acagactttt taggaaactc
      901 ggaccagacg tgactcggct gtcaccccac tggtgccgcg gagcgcgtac actcagggaa
      961 ccaggccctt acacacgcct tacttggtgt atttccccac tcgtgcacat gggcggttcg
     1021 taatccagca taaagatggg gggcacattt gcaatgtgct gtaagtgggg tgtcaacgct
     1081 tgtgttgcac ccgggtaaat ggagttgatc tgagctgccc tttacttaaa aaccctttgg
     1141 gaaaagggtg gaagaaatta aaattgaaac aataagaaaa ataaaaatgc aaaagaactg
     1201 a
//
LOCUS       NM_001106357            5930 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 5 (Smc5),
            transcript variant 3, mRNA.
ACCESSION   NM_001106357 XM_001078644 XM_215254
VERSION     NM_001106357.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5930)
  AUTHORS   Raschle,M., Smeenk,G., Hansen,R.K., Temu,T., Oka,Y., Hein,M.Y.,
            Nagaraj,N., Long,D.T., Walter,J.C., Hofmann,K., Storchova,Z.,
            Cox,J., Bekker-Jensen,S., Mailand,N. and Mann,M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 5930)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   3  (bases 1 to 5930)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   4  (bases 1 to 5930)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   5  (bases 1 to 5930)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   6  (bases 1 to 5930)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (bases 1 to 5930)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (bases 1 to 5930)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001106357.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000001.1  230265372-230265621 c
            251-392             JAXUCZ010000001.1  230260591-230260732 c
            393-445             JAXUCZ010000001.1  230258553-230258605 c
            446-608             JAXUCZ010000001.1  230257157-230257319 c
            609-743             JAXUCZ010000001.1  230254913-230255047 c
            744-884             JAXUCZ010000001.1  230253016-230253156 c
            885-1046            JAXUCZ010000001.1  230251195-230251356 c
            1047-1118           JAXUCZ010000001.1  230248476-230248547 c
            1119-1374           JAXUCZ010000001.1  230242698-230242953 c
            1375-1529           JAXUCZ010000001.1  230241244-230241398 c
            1530-1624           JAXUCZ010000001.1  230227615-230227709 c
            1625-1757           JAXUCZ010000001.1  230225850-230225982 c
            1758-1931           JAXUCZ010000001.1  230223379-230223552 c
            1932-2101           JAXUCZ010000001.1  230223126-230223295 c
            2102-2225           JAXUCZ010000001.1  230220574-230220697 c
            2226-2348           JAXUCZ010000001.1  230220012-230220134 c
            2349-2474           JAXUCZ010000001.1  230211473-230211598 c
            2475-2519           JAXUCZ010000001.1  230208551-230208595 c
            2520-2615           JAXUCZ010000001.1  230208051-230208146 c
            2616-2720           JAXUCZ010000001.1  230207469-230207573 c
            2721-2840           JAXUCZ010000001.1  230207167-230207286 c
            2841-3020           JAXUCZ010000001.1  230199842-230200021 c
            3021-3116           JAXUCZ010000001.1  230199669-230199764 c
            3117-5930           JAXUCZ010000001.1  230195894-230198707 c
FEATURES             Location/Qualifiers
     source          1..5930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..5930
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
     exon            1..250
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3260
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="isoform 3 is encoded by transcript variant 3; SMC5
                     structural maintenance of chromosomes 5-like 1; structural
                     maintenance of chromosomes protein 5"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5
                     isoform 3"
                     /protein_id="NP_001099827.1"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
                     /translation="MATPSGKAAAPNPQASKRSLPRDASSEFPSKRKNSNPTSTLPRP
                     SGLFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKI
                     VEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNF
                     REKEKQLETSCKEKTEYLDKMIQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQRRTLEVRIKEKATDIKEA
                     SQKCKQRQDLIERKDRHIKELQQALTVKQNEEQDRQKRISNTRKMIEDLQNELRTAEN
                     CENLQPQIDAITNDLRRVQEEKALCEGEIIDKQREKEMLEKQKRSVSDHITRFDNLMN
                     QKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTVRDNKKLRVNAVIAPKISYA
                     DKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVI
                     QETRLKQIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEI
                     NRKLEAVDSGLVALRDTNRHLELKDNELRLKKKELLERKTKKRQLEQKISSKLASIRL
                     MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSLHIQKVDLILQNTTVI
                     SEKNKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKRARQVCNLSADQAVP
                     QEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYT
                     KREIEIQQLTEELKGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQC
                     AGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQEL
                     NRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTV
                     LFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPSQ"
     misc_feature    216..>653
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    216..>653
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    222..3107
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    222..3107
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    303..326
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    303..326
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    597..608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213179"
     misc_feature    597..608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213179"
     misc_feature    <2874..3182
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <2874..3182
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    2922..2951
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213179"
     misc_feature    2922..2951
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213179"
     misc_feature    2994..3011
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213179"
     misc_feature    2994..3011
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213179"
     misc_feature    3018..3029
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    3018..3029
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    3099..3119
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213179"
     misc_feature    3099..3119
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213179"
     exon            251..392
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..445
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..743
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..884
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1046
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1118
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1374
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1529
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1624
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1757
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1931
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2101
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2225
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2348
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2474
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2519
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2615
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2720
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2840
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3020
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3116
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..5930
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggctc ctgggctgcg gctcgccggg aacggaagcc gctgcgggac gcggaggaag
       61 ccaggatggc gactccgagt gggaaagctg ctgcccctaa cccccaggct tccaagaggt
      121 ctctcccgag agatgcttcc tccgagttcc cgagcaagag aaagaactcg aacccgacgt
      181 cgacgctgcc gcggccgtcc ggactcttcg tggagggctc aatcgtccgc atcgccatgg
      241 agaacttctt aacatatgac atctgtgaag tgtctcctgg gccccatctg aatatgatta
      301 ttggagccaa tggaacaggg aagtcaagca tagtgtgtgc catttgcctt ggcctagcag
      361 gcaagcctgc tttcatgggg cgtgcagata aggttgggtt tttcgtgaag agaggatgtt
      421 ccaaaggttt ggttgaaatt gaactgttca ggacttctgg aaatcttata atcacccgtg
      481 aaattgatgt gataaaaaat cagtcctttt ggttcatcaa caaaaaacct gtaacccaga
      541 agatagtgga agagcaagtc gcggccttga acatccaagt gggcaacctc tgccagttct
      601 tgcctcagga caaagttgga gaatttgcta aactcagtaa aattgaactc ctcgaagcta
      661 ctgagaagtc aattggtcct ccagagatgc acagatacca ctgtgaactc aagaacttca
      721 gggagaagga gaagcagcta gagacttctt gcaaagagaa aactgaatac ctagacaaaa
      781 tgattcagag aaatgaaagg tacaaacaag atgtagaaag attctatgaa cgaaaacgac
      841 atttagattt aattgagatg cttgaggcaa aaagaccatg ggtggaatat gagaatgtgc
      901 gtcaggaata tgaaggtgtg aaactagtcc gtgaccgagt gaaggaagag gtcagaaaac
      961 tcaaagaagg gcagattcct atgacacggc ggattgagga aattgaaagg cagcgtcgca
     1021 ctttggaagt tcgaatcaaa gaaaaggcaa ctgatattaa ggaagcgtct cagaaatgca
     1081 aacaaaggca ggacttgatt gagcggaagg acagacatat taaggaactt cagcaagcat
     1141 taacagtcaa gcagaatgag gagcaggacc ggcagaagag aataagtaac acccgcaaga
     1201 tgatagaaga cttgcagaat gagctcagga ctgcagaaaa ctgcgagaac cttcagcctc
     1261 agattgatgc catcacaaat gatctaaggc gtgttcaaga ggagaaggca ttatgtgaag
     1321 gcgagatcat tgataaacag agagaaaagg aaatgctgga gaagcagaaa cggagtgtga
     1381 gtgatcatat cacacgtttt gacaatctta tgaatcagaa ggaagataag ctgagacaga
     1441 ggtaccggga tacgtacgat gcagtcttgt ggctgagaaa taacagagac aggtttaaac
     1501 aaagagtctg tgagcccata atgctcacgg ttcgtgacaa taagaagttg agagtaaatg
     1561 ctgttattgc tcccaagatt tcatatgcag acaaagcacc ttcacgatct ctgaatgagt
     1621 taaaacagta tggctttttt tcataccttc gagagttatt tgatgcaccc gatcctgtga
     1681 tgagttacct ttgctgccaa tatcatattc atgaagttcc tgtgggaact gaaaggaccc
     1741 gagaaagaat tgaacgggta atacaagaaa ctcgattaaa acagatttat acagcagaag
     1801 aaaagtatgt gttaaaaact tctttctatt ccaataaagt tatctctagt aatacatctc
     1861 tgaaagtagc ccagttcctc actgtcactg tggacctaga gcaaaggaga cacttggaag
     1921 aacagctaaa ggaaattaat agaaagctgg aagcagtgga ctcaggattg gtagccttgc
     1981 gggatacaaa caggcatctc gagctcaaag acaatgagct aaggctgaag aagaaggagc
     2041 ttcttgaaag aaaaaccaag aaaagacaac tggaacagaa aattagctcc aagctggcaa
     2101 gtataaggct gatggaacag gatacttgca atctggaaga ggaagaacga aaagcaagta
     2161 ccaaaataaa agaaataaat gttcaaaaag caaaacttgt tactgaatta acgggccttg
     2221 taaagatatg cacttctttg catattcaaa aagttgattt gattcttcaa aatactacag
     2281 tgatctctga gaagaacaag ttagaagcag attacatggc gtcctcctca cagctgcgtg
     2341 tcacagaaca acagtttatt gaattggatg acaataggca gagattgtta cagaagtgca
     2401 aggaacttat gaagagagct aggcaagtat gtaacctgag tgcagaccaa gccgttcccc
     2461 aagaatttca gacacaagta cccaccattc caaatggaca cagctcctca ccccccatgg
     2521 cttttcaaga tctcccaaac acattggatg aaatcgatgc attattaact gaagaaagat
     2581 caagagcgtc ctgcttcaca ggactgaatc cttcggtggt tgaggagtac acaaaaagag
     2641 aaatagaaat acagcagtta actgaagaac taaaggggaa gaaagttgaa ttagatgaat
     2701 acagggaaaa catttcgcag gtgaaagaaa ggtggctgaa ccccttaaaa gagctagtag
     2761 agaaaatcaa tgagaagttc agcaactttt ttagttccat gcagtgtgct ggtgaagttg
     2821 atcttcatac agaaaatgag gaagattatg ataaatatgg aatccggatt agagtaaaat
     2881 ttcgcagtag tactcagctg catgaattaa ctcctcatca tcaaagtggc ggtgaaagaa
     2941 gtgtttctac catgctgtac ttgatggcac ttcaggagct taacagatgt ccattcagag
     3001 tggttgatga aattaatcag ggtatggacc caattaatga acggagggtg tttgaaatgg
     3061 ttgtgaacac cgcctgtaaa gagaacacat cgcagtactt cttcatcaca ccgaagcttc
     3121 tacagaatct gccttattct gaaaagatga cggtattgtt tgtctacaat ggtcctcata
     3181 tgctggaacc aaaccgatgg aatttaaagg cttttcaaag gcggcggcga aggatcacat
     3241 ttactcaacc ttctcagtga aaggaaaggg aggggcctgc cgaggttttc atttaactgt
     3301 ttatacctgt cgctcaagtg aataaaagtt agcagattta ttgaaagaga aagattggtt
     3361 atttttggaa gcctgctttt aaaaacaaat aggttaatga agcggagacc atagtgactc
     3421 tggaccattt ctagtgaaaa ctaagtcttc agttttggtg gaccttgtct cattagtcct
     3481 ctgtgagcat tgttgtgtga agctttgtgc tgcctcaggt gtggtggcac acatctagtc
     3541 cagcatttag gagacggagg cagaaagatc atgagtttga gtggtttcat gtgtcttaac
     3601 agaaaaagct atttccggtt gcaaatcaga ggtacggcag aatggggttt cattcacaga
     3661 gcgtttacaa acaatagccg ccctgagtgc tgattgcaga acatcctgac tcttagtgct
     3721 taaaggtaac tcagaattag aaatcccatt tgccttcagt attgtattta gtttttaaaa
     3781 actagtatga gaatgtctgc ttagtagata gtgatttatg gcagatctgt tcatttcttt
     3841 gtgtttagaa gaagggttcc cttattttca tagaaaatat gttatcgtag aaaattgatg
     3901 ctataatttt attgttattt caaagaattg ggaagacata tacacgtgag gcttcaaaat
     3961 gacaggagga ctttgagagg tcacaaggta aagatgatac agaatgtggc ccaaacattg
     4021 gcagagtgaa atcaggtgac aggagttaaa gtataattgt tgtgtgtgtt tgtcgggggt
     4081 gggttctttg tttgtttgtt taatttaaag tcaaatgtat tttacatctt aaatttctac
     4141 aaaggcattt ttataatttt agtaagattt ttcttaagat ttcatatatg agattttaca
     4201 atttgtattt gaaatttctc agtgctatgt aaagagtgaa ggcaaagaat tgattggttt
     4261 caaatcataa tatttttaga atttgtatgt ccttccttct acccagtatt ttagaaaact
     4321 ctcatctaaa ttgttttctt ccagcttgaa aatattaatt gaaaaccatt tatttttctc
     4381 tgagaatgct aattaacaat gccaaacaaa ttctgtttgt ttgttttttt tttaaacaaa
     4441 tcttgaaaga aagtagaaat gtctttgaat agtggactga actgtatcct tgctggtact
     4501 gacaaaatta tttttgtgac tagctagcct gaataaagtt tgggctttgt atattattgt
     4561 aatagccaat gagatttgca ttcttattag gtcaaaaaat agtgaaacat gagtttatgt
     4621 ctgctcactt agacattttc tcttttagaa gttgtatttc tttttaacac ttgtaaaaga
     4681 acccttccct cttaaactac atctcataca tgtagtataa agatattttt aataacattt
     4741 ttatcagcat gaacaagtca aaaaattaaa aactaggtag gatagtagtg aagggtgttt
     4801 ctaaacattt gtgtcgttgc ttggatttct gacataatta atatcttcac tgatatatgc
     4861 ttaatatagt ttggttttat catgtcaatg tgaaacaaaa acaaaccgta cttaaaactc
     4921 aacatcagca atcccatttc agtttacata tgtcaaaaat gattctatat catgcttata
     4981 aactttcaga gagcaaaatt aatgttcgtt ttatattgac tttgggctgg gaaggataaa
     5041 ttatgtatca tttattatat taaaaatagt catactataa tgtcattttc tgcaactgtt
     5101 gatttttaag attatattat aattgtaaaa attccaagta aaagcttgat ttgataaata
     5161 aaatatttaa aacctgacag ttacaaatat ttgtaatgac gaaatgttta cattgatttg
     5221 cccaaggtca gtctctgtta gaaggtttct cattttcaaa aaaaggttgt tttgtttttt
     5281 gtaaggttta tttattttat gtgagtcggt tttttctgca tgtatgtatt atacccggtg
     5341 cttgttaagg ccagaagaga gcatcagatc ccctaggagt agaggtaaag gtagtcgtga
     5401 gctgctgtat tgagtgttgg gtatagaagc tgggtcctgt ggaagagcag ccaggaggtt
     5461 taaccactga gccatctctc cagtcccaaa aagagatttc ttgctgcttt cccatagcct
     5521 tggacataag tctatagcac aggaggggca tcacttcact ctggtttgtg taaatgtaat
     5581 tgattaaaac tatgttgtaa atgctacttc attggtaata aataatatat tttcccattg
     5641 gtataggtta tttaagatga gagtatttta atactttaaa ttttcttaaa agtctttttt
     5701 tttatctctc tttttttttt ttttttaaag atttattcat ttattatata taagtacact
     5761 gtagttgtct tcagatacac cagaagaggg caccggatct ctttacagat ggttgtgagc
     5821 caccatgtgg ttgctgggaa ttgaactcat gacctctgga agagcagtcg ggtgctctta
     5881 accgctgagc catctctcca gcccaaaagt cattttttat tttcaggatt
//
LOCUS       NM_001134969            4638 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus ankyrin repeat domain 6 (Ankrd6), transcript
            variant 1, mRNA.
ACCESSION   NM_001134969 XM_001056902 XM_575792
VERSION     NM_001134969.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Haribaskar,R., Putz,M., Schupp,B., Skouloudaki,K., Bietenbeck,A.,
            Walz,G. and Schafer,T.
  TITLE     The planar cell polarity (PCP) protein Diversin translocates to the
            nucleus to interact with the transcription factor AF9
  JOURNAL   Biochem Biophys Res Commun 387 (1), 212-217 (2009)
   PUBMED   19591803
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of rat Ankrd6 gene in silico
  JOURNAL   Int J Mol Med 15 (2), 359-363 (2005)
   PUBMED   15647854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Sep 15, 2008 this sequence version replaced
            XM_001056902.1, XM_575792.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168675.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4638
                     /gene="Ankrd6"
                     /note="ankyrin repeat domain 6"
                     /db_xref="GeneID:500430"
                     /db_xref="RGD:1583731"
     exon            1..211
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            212..475
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    350..352
                     /gene="Ankrd6"
                     /note="upstream in-frame stop codon"
     CDS             356..2497
                     /gene="Ankrd6"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 6"
                     /protein_id="NP_001128441.1"
                     /db_xref="GeneID:500430"
                     /db_xref="RGD:1583731"
                     /translation="MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRT
                     PLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALD
                     RQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRVL
                     LLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLSAFCSVHEKNQAGDTALHVAAALN
                     HKKVVKILLEAGADTTLVNNAGQTPLETARYHDNPEVALLLTKAPQILRFSRGRSLRK
                     RRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPEKEEARRDCPPASQEPRKD
                     ERRRKSRPEVSALSDPTPAADQQPGHQKNLHGHHHQKKKSRHRCWSPPPPHGFRAYQL
                     YTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEAAVEELRAELGTVQDKVNTKLGHME
                     SKSQHQMCVLDKLMVERLSAERTECLNRLQQHAAAEKQEGEKRQMSLVDELKSWCMLK
                     IQNLELRLSGESRTFRAKSTPSPSDSSPAVDQPVVAAGPGAASDSSSQVVRPKDKALN
                     ATAVPRHQQELLPSDCTGSGLRKVKAPAASRLGDQQTGSCVNRGTQTKKSARGGQTKH
                     RGQQPTASSPSGQQPSAASSDARDASQALELTQYFFEAVSAQMEKWYERKIEEARSQA
                     SQKAQQDEATLKEHIRSLEEEVAKLRTKMHK"
     misc_feature    368..1087
                     /gene="Ankrd6"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    368..1087
                     /gene="Ankrd6"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(476..478,482..484,494..499,506..514,518..523,
                     533..535,542..544,569..571,575..577,581..583,593..598,
                     605..613,617..622,632..634,641..643,668..670,674..676,
                     680..682,692..697,704..712,716..721,731..733,740..742,
                     767..769)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(476..478,482..484,494..499,506..514,518..523,
                     533..535,542..544,569..571,575..577,581..583,593..598,
                     605..613,617..622,632..634,641..643,668..670,674..676,
                     680..682,692..697,704..712,716..721,731..733,740..742,
                     767..769)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    476..571
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    476..571
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    575..670
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    575..670
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    674..769
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    674..769
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    776..868
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    776..868
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(779..781,791..796,803..811,815..820,830..832,
                     839..841,866..868,872..874,878..880,890..895,902..910,
                     914..919,929..931,938..940,965..967,971..973,977..979,
                     989..994,1001..1009,1013..1018,1028..1030,1037..1039,
                     1064..1066)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(779..781,791..796,803..811,815..820,830..832,
                     839..841,866..868,872..874,878..880,890..895,902..910,
                     914..919,929..931,938..940,965..967,971..973,977..979,
                     989..994,1001..1009,1013..1018,1028..1030,1037..1039,
                     1064..1066)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    872..967
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    872..967
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    971..1066
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    971..1066
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    <1988..2473
                     /gene="Ankrd6"
                     /note="triacylglycerol lipase; Region: PLN02847"
                     /db_xref="CDD:178439"
     misc_feature    <1988..2473
                     /gene="Ankrd6"
                     /note="triacylglycerol lipase; Region: PLN02847"
                     /db_xref="CDD:178439"
     exon            476..574
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            575..673
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            674..772
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            773..871
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            872..970
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1069
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1147
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1252
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1384
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1570
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1723
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1837
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1964
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..4638
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgtcgtg cctttgtgct ggctgtccct tgtcccacag aggctagcga ggtcggtaag
       61 agtcctccat tgtgaaactc cattgtggtc tgaggctgga ctgaaggttc tgccagcccg
      121 cgtggccaga gctgcgtctt gggagtgctc tttcctggat gtggacagag ggactcttga
      181 cagggtttga agtggaaatg agaactacta gggcctgaag atggagtagt aacaaaggca
      241 tcccccatga ttctcagcac ccttccctgt ggactccagc cccagccaga ggctgcatgt
      301 ggagctgaag aaactgacca gctgctttcc tgagagcccc tttctctcct aattcatgag
      361 ccagcaggat gcggtcgccg cgctttcaga acgcctgctc atagctgcgt acaaaggcca
      421 aacagagaat gtggttcagc tcatcaacaa gggtgccaag gtagcggtta ccaagcatgg
      481 ccggaccccc ttgcacctcg ctgccaataa gggtcatctt tctgtggtgc agattttgct
      541 gaaggctggc tgtgacctcg atgtacaaga tgatggggac cagacagcct tgcaccgggc
      601 cactgtggtg ggcaacactg agatcctcac agcgcttatc cgggagggat gtgccctgga
      661 cagacaggac aaggatggga atacggccct gcatgaagcc gcctggcatg gattcagcca
      721 gtcagccaag ctgctcgtta aagccggagc caacgtgctt gccagaaaca aggcagggaa
      781 cacggctctg cacctggcct gccagaatag tcactcccag agcacacgcg tcctcctgct
      841 gggcggctcc cgggctgacc tcaaaaataa tgcaggggac acctgcttgc acgtggctgc
      901 gcgctataac cacttgtccg ttgttagact cctcctcagt gctttctgct ctgttcatga
      961 aaagaaccag gctggagaca cggccctcca tgtggccgct gccctaaatc acaagaaggt
     1021 agttaaaatc ctgctggaag ccggtgctga cacgaccctt gtgaacaatg cagggcagac
     1081 cccactggag accgcccgct accacgacaa tcccgaagtt gctctgctcc tcaccaaggc
     1141 tccccagatc ttgcgcttca gtcgtgggcg aagcctgagg aaaaggaggg agaggctcaa
     1201 ggaagagagg agggctcagt ctgtgcccag agatgaggtg gcccagagca agggaagcgt
     1261 ctcagcagga gacaccccca gcagtgaaca agctgtaccc gaaaaggaag aagctaggag
     1321 agattgccca ccagcttccc aggagccaag aaaggatgaa aggaggagaa agtcaaggcc
     1381 agaggtgtca gcactatctg accccacccc agcagcagac caacaacctg gacaccaaaa
     1441 gaacctacat ggtcatcacc accaaaaaaa gaagagcaga catcgatgct ggtccccacc
     1501 accgccccac gggttcaggg cgtaccagct ctacacgctg taccgtggcg aggacgggaa
     1561 agtgatgcag gcaccaatca aaggttgtcg ctgtgagcct ctgatcaaca agctggagaa
     1621 ccagctggag gcggctgtgg aggagttaag agctgagctg ggaacagtgc aggacaaagt
     1681 gaacacaaag ctgggccaca tggagagcaa gagccagcac caaatgtgcg ttttggacaa
     1741 actgatggtg gagcggctgt cagctgagag aacggaatgt ctgaatcgcc tgcagcagca
     1801 tgcagctgct gagaagcagg agggagagaa acgtcagatg tcattggtgg atgaactgaa
     1861 atcctggtgt atgttgaaga tccagaatct ggagttgaga ctttcgggag agtctcggac
     1921 ctttagagct aaatccacac catctccctc cgactcctct ccagctgtag accaaccagt
     1981 ggtagctgca gggccgggag cagcttccga cagctcctct caggttgtga ggcccaagga
     2041 caaggcactc aatgccactg ctgtccccag acaccagcag gagctgcttc cctctgattg
     2101 cacaggctcc gggttaagga aggtcaaggc cccggctgct tccagactgg gtgatcagca
     2161 gactgggtcc tgtgtcaacc gaggcactca aaccaagaag tctgcgagag gtgggcagac
     2221 caagcatcga ggccaacaac cgacagccag cagccccagt gggcagcagc catccgcggc
     2281 aagcagtgac gcccgagatg cctcgcaagc cctggagcta acccagtatt tttttgaggc
     2341 tgtttctgct cagatggaaa agtggtacga acggaaaatt gaagaagcac gaagccaggc
     2401 cagtcagaaa gctcagcaag atgaggccac actgaaggag cacatcagga gtctagaaga
     2461 ggaggttgcc aagctgcgca caaagatgca caagtaaaac cagattctga agtggaccca
     2521 gcagggtttc cagcttgata acagcaaagt aactgtgtcc ccggagttgg ttgtcatgca
     2581 caaggtggat ttgcctttaa tagagtcact aattggttgt ggacacatac ttcgtgctct
     2641 gaagttacaa ggccttcact ggttaaaatg aatcctggga agatgtctat aaacagcaag
     2701 acaccaagaa gaggaggtgt gacccacgtc tgtgattcat gaagtgtgtc agaagcaaag
     2761 cagagaactc tgggaaccca gtagccattc acgtccatgc caacacacct gctgtgccta
     2821 gacggtcctt ctagcagagc tgggactcag atgcgggaag ccctctttct cccatgtaac
     2881 tcaagatgct catcttttaa aggggtgaaa ccctttcagg ttgtgaggat atacactgta
     2941 atgacctcag tgtccagtgt gtcttcaagt aagtttaagg atcatataaa ggagtagcaa
     3001 ttgctgactg tcaagtgaga agggtttaaa ccattggtca gttactgtga ttttggccaa
     3061 ataactgagc agattaatgg aaaaatattc accaaacaac tccagccagt taccttagat
     3121 tacctttcta gagtcaagac gtttgttcca tgttttgtaa agaaatcagg aaatatcacg
     3181 aaagtttaat tttgaattga cttctcactg aagaacatca agccgtcaaa aggcgttgcc
     3241 tgtttactga gtaagatgta ccagactgag gtggtgactc tatcttggtt gggaccttgg
     3301 atttgcctaa tcctttggta catggaacac ggattatgtc tgtctccaca tatgcataga
     3361 aacgtatgtt tctctaagcc taaggaccta ataactacta tccatgaatt gtaactaaaa
     3421 tgctgttcat tgagccaaag agaagtgatc tttgcggaat agtatgcatt tatgccttgg
     3481 tcaagccaag ttcttccttt tgcttatagt gacaatccac ggatagacat tcgtataaac
     3541 acgacagggc agatattggg tatgcatcat ccagtgagcc caattatttc ctgggaccga
     3601 cctatcctca gcctcttggg aggtacagcc cttccccatt ctccttcacc ggagtcctgt
     3661 cctcagctca cttgcacctg agccctgcta tgacactacc cacaacaaaa tgtcactcac
     3721 tcctgtagga tcactcctta ttcatacagc aaattattgg gaactgccta atactaagta
     3781 agagatgaaa ccccgagttc agcatgagtt attttcacta ttagaatact cattacctca
     3841 agaaaccctt gacaagaagg gcagaaatca actgtaactg aacatcaagt ctagaccaca
     3901 gaatatctta gtggcagtgc tttgatgata tcctcctacc tatgagaagc aggcagctta
     3961 tcactgtgaa tggatgtttt tgtcaagtca ttaagcataa agaccaggct attgtctaag
     4021 gccagtcagc cccttaccca cagggttgac ttctgaggaa gtggtggttg gcttgttttt
     4081 ggaaggctta ccgtgtactc tagactggct ttggtctcat gaccttcctg tcgcagccac
     4141 ctgagttggg actaaaggag tgagccccat ggccaatcat gttttgtttg taacaccagt
     4201 gttaggtttg tggcaattgg tcctcagcat tgtacagcac tgaggatcag ctgtgtcttt
     4261 cccctcgtgc tgtgtgcaaa aaacaaatat cccagctgta cttttacaga taactgctca
     4321 taccatacac tctcacaata ggtcatgttt caaaccgagg cctaaaaagt gtcaacagcc
     4381 gtgaagaaac atgttataaa acagtagtgt tgcatatcaa tgtccttttt aaaaaacagg
     4441 taattgttag cacatccctt agagtgcata ctgagcatct gtgctggggt gaaagtgtta
     4501 gtctagcatc acttttgatg tggagtccaa aatacaggtt tttcatgttt agatttgtgt
     4561 gtgcaaggca tgctgtctaa tttttttagt caccttgaac ttgtgtctcc tataagcatt
     4621 aaacgtttga gttctgtc
//
LOCUS       NM_001438018            1866 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus stomatin like 3 (Stoml3), mRNA.
ACCESSION   NM_001438018
VERSION     NM_001438018.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Morgan,M., Thai,J., Nencini,S., Xu,J. and Ivanusic,J.J.
  TITLE     Stomatin-like protein 3 modulates the responses of Adelta, but not
            C fiber bone afferent neurons to noxious mechanical stimulation in
            an animal model of acute experimental bone pain
  JOURNAL   Mol Pain 19, 17448069231222407 (2023)
   PUBMED   38073226
  REMARK    GeneRIF: Stomatin-like protein 3 modulates the responses of Adelta,
            but not C fiber bone afferent neurons to noxious mechanical
            stimulation in an animal model of acute experimental bone pain.
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Tadenev,A.L., Kulaga,H.M., May-Simera,H.L., Kelley,M.W.,
            Katsanis,N. and Reed,R.R.
  TITLE     Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory
            function, protein localization, and axon targeting
  JOURNAL   Proc Natl Acad Sci U S A 108 (25), 10320-10325 (2011)
   PUBMED   21646512
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Wetzel,C., Hu,J., Riethmacher,D., Benckendorff,A., Harder,L.,
            Eilers,A., Moshourab,R., Kozlenkov,A., Labuz,D., Caspani,O.,
            Erdmann,B., Machelska,H., Heppenstall,P.A. and Lewin,G.R.
  TITLE     A stomatin-domain protein essential for touch sensation in the
            mouse
  JOURNAL   Nature 445 (7124), 206-209 (2007)
   PUBMED   17167420
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Kobayakawa,K., Hayashi,R., Morita,K., Miyamichi,K., Oka,Y.,
            Tsuboi,A. and Sakano,H.
  TITLE     Stomatin-related olfactory protein, SRO, specifically expressed in
            the murine olfactory sensory neurons
  JOURNAL   J Neurosci 22 (14), 5931-5937 (2002)
   PUBMED   12122055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.166874.1,
                                           SRR26360176.1265322.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760393,
                                           SAMN06621351 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000002.1  139722966-139723143
            179-282             JAXUCZ010000002.1  139732078-139732181
            283-355             JAXUCZ010000002.1  139732262-139732334
            356-438             JAXUCZ010000002.1  139734395-139734477
            439-642             JAXUCZ010000002.1  139736023-139736226
            643-777             JAXUCZ010000002.1  139738050-139738184
            778-1866            JAXUCZ010000002.1  139739875-139740963
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1866
                     /gene="Stoml3"
                     /note="stomatin like 3"
                     /db_xref="GeneID:295041"
                     /db_xref="RGD:1311090"
     exon            1..178
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1002
                     /gene="Stoml3"
                     /note="stomatin (Epb7.2)-like 3"
                     /codon_start=1
                     /product="stomatin-like protein 3"
                     /protein_id="NP_001424947.1"
                     /db_xref="GeneID:295041"
                     /db_xref="RGD:1311090"
                     /translation="MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLITFPVSIW
                     MCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEIL
                     TRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGR
                     EEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAE
                     GEMNASKSLKSASMVLAESPIALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGIS
                     YDNNKKVTAKA"
     misc_feature    343..939
                     /gene="Stoml3"
                     /note="core domain of the SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; Region: SPFH_like;
                     cl19107"
                     /db_xref="CDD:473137"
     misc_feature    343..939
                     /gene="Stoml3"
                     /note="core domain of the SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; Region: SPFH_like;
                     cl19107"
                     /db_xref="CDD:473137"
     exon            179..282
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     exon            283..355
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..438
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..642
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..777
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1866
                     /gene="Stoml3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctactcctca gggtatatgc caaggagagg gagcctctct tgctctccac acgcacgcca
       61 ccgagctggt gtctgctgct gggcttgaat cccgacccag gaccatctgc gagatttgac
      121 aaacgtctca agaatgagat ggattcaccc gagaaactgg agaagaacaa tttagtgggc
      181 accaacaaaa gccggcttgg tgtatgcggc tggattctgt ttttcctttc cttcctgttg
      241 atgctcatta ccttcccggt ctcaatatgg atgtgcttga agatcattaa ggagtatgag
      301 cgtgctgttg tcttcagact gggacgcatc caagctgata aagccaaggg accaggtttg
      361 atcctggtcc tgccttgcat tgacgtgttt gtcaaagtgg atcttcgaac agttacctgc
      421 aacattcctc cacaagagat cctcacgaga gactctgtga ccacccaagt ggatggagtc
      481 gtctactaca gaatctacag cgccgtctca gccgtggcca acgtcaatga tgttcaccag
      541 gccacgtttc tgctggctca gaccactctg agaaatgtct tagggacaca gaccttgtcc
      601 cagatcttgt ctgggcgaga agagattgca catagcatcc agaccttgct tgatgatgcc
      661 actgagctat ggggaatccg agtggcccgg gtggagatca aagatgtccg gattccggtg
      721 cagctgcaga ggtccatggc ggctgaggct gaggctaccc gggaagccag agccaaggtc
      781 cttgcagctg agggagaaat gaacgcttct aagtctctga agtcggcttc catggtgctg
      841 gctgagtccc ccatcgccct ccagctgcgg tacctgcaga ccttgaccac ggtggccacg
      901 gagaagaatt ccaccattgt gtttcccctg ccgatgaaca tactcgaggg cattggtggc
      961 atcagctatg acaacaataa gaaggtcact gctaaagcct gaggtcttcc aagtcaacgc
     1021 ctgctgctta gaaaggcctt tctgtaccat ggagaagtca gccattagag gacacacaca
     1081 cacacacaca cacacacaca cacacacaca cacacacaca cacacaccat gcaagctaca
     1141 gtaactccac agctatcaaa attcccagag agagacatag aagctacaca aacaacaaca
     1201 acaacaaaaa ccaaaattta gagtcgtgca ctacatttac tttaaaggca taaccaacat
     1261 tcatatgcaa ttagttagtg gttgtccctg accgtcagca gggactctct caggagggtc
     1321 ggagactcta ggtgaccatg ataagaactt tagaatgtag gctgcgttgg agaaggagcc
     1381 taggtcattc ataaaggaag gcagatcctg cttttatgct atgcacttga ttcgctgttc
     1441 cagcaaaatg agctgctcta gtaactctag gaagaaatcc cctcaagact gaaaattagg
     1501 acccacacgg atgtagaaaa caagaaagag ctgcagcgtg acagcaacac agggcaaagg
     1561 taccagccca ggcccagctc tctggacacc agtatgtcct gttaaaatgt tggccattct
     1621 cagtcccctc acacatttgt cagggccaga ggcacagcgg gggcagaaga ccacaggcta
     1681 atttgcttac tggtaacacc ttcgaagtca ctggggaggt cgttctgtga attgcatgtt
     1741 ttcactctgc aagtcccaag agccatagtg attaagaact gtttgtaatt tttccccagc
     1801 tcgaacaact tgtcgcaaat aataataaca ataaaaaagt catagaaagt gaacatgatt
     1861 ttaaaa
//
LOCUS       NM_001438020            1268 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus leucine rich repeat containing 69 (Lrrc69),
            transcript variant 1, mRNA.
ACCESSION   NM_001438020 XM_017593569
VERSION     NM_001438020.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_017593569.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2174156.1,
                                           SRR26360186.2569048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000005.1  32978973-32979194   c
            223-349             JAXUCZ010000005.1  32949199-32949325   c
            350-422             JAXUCZ010000005.1  32947930-32948002   c
            423-618             JAXUCZ010000005.1  32943221-32943416   c
            619-690             JAXUCZ010000005.1  32939872-32939943   c
            691-792             JAXUCZ010000005.1  32891856-32891957   c
            793-972             JAXUCZ010000005.1  32874201-32874380   c
            973-1088            JAXUCZ010000005.1  32851870-32851985   c
            1089-1268           JAXUCZ010000005.1  32820838-32821017   c
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1268
                     /gene="Lrrc69"
                     /note="leucine rich repeat containing 69"
                     /db_xref="GeneID:500415"
                     /db_xref="RGD:1583733"
     exon            1..222
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1083
                     /gene="Lrrc69"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 69"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 69
                     isoform 1"
                     /protein_id="NP_001424949.1"
                     /db_xref="GeneID:500415"
                     /db_xref="RGD:1583733"
                     /translation="MVTSSKIMTERLLLTALKGGKSTKILTLNGKKMSKMPSALEKLP
                     NLRTLDLQNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGNRI
                     CRIAAGVLDGLGDLVLLNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLE
                     HLSELHINYNRITRIPEEIRFLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVI
                     QIFPAGFQDLKLREFYCEGNPLFLKNPIFAPQPKDLWTLREIAARFVLSQLEEYNPLI
                     MDAIECYPEVKDKLSKAKKCAICRKPFLSEWLECVYFVPPSKNWKISKNLQLIPLQTL
                     VCSYQCFDRRDPDVFGIAKE"
     misc_feature    <61..>738
                     /gene="Lrrc69"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <61..>738
                     /gene="Lrrc69"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    85..153
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    85..153
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    154..291
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    154..291
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    292..363
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    292..363
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    364..432
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    364..432
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    433..501
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    433..501
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    502..570
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    502..570
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    571..639
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    571..639
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    640..705
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    640..705
                     /gene="Lrrc69"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            223..349
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            350..422
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            423..618
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            619..690
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            691..792
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            793..972
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1088
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1268
                     /gene="Lrrc69"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aataactctt gccccataat ggttacctct tcaaaaatca tgactgagag attattgcta
       61 acagcactga agggtggcaa gagcactaag atccttactt tgaatgggaa gaagatgagc
      121 aagatgccct cagcactgga aaaactgcct aatctgagga ctctagacct tcagaataat
      181 caaatctcca aagtatgccc tgagctaagg accttgacca agttgacatt actaaatctg
      241 ggaaacaacc ttttacaaga agttcctgaa gagataaaat accttacctc cctgaagaat
      301 cttcatttat ttggaaacag gatttgcaga attgctgctg gagtccttga tggcctggga
      361 gacttggttc tacttaatct gaatgacaac caacttagca gtcttcctcc agaaattggc
      421 agattacaga atctcacctt cctaagcctc aaccataaca agctcaccgt gattcccaaa
      481 gagatctgtt tccttgaaca tctttcggaa cttcatatta actacaatcg gatcacgcgc
      541 atccctgagg agatcaggtt cctacagaac cttcagcagc tttctctggt caggaacaac
      601 atcgaagagt tgccagagga agtttgtcag cttacaaaac taggagtcct ggacgtagct
      661 ggaaatgtaa tccagatatt tccagcaggc tttcaggatc taaagctgag ggaattctac
      721 tgtgagggaa acccactctt cctgaagaat ccaatttttg ctccacaacc taaagatctc
      781 tggactctac gggaaatagc agcaagattt gtcctctctc aattagaaga atacaaccct
      841 ttgattatgg atgccataga gtgttaccca gaggtcaagg acaaactctc caaagcaaaa
      901 aaatgtgcaa tatgcagaaa acctttttta tctgagtggc tggaatgcgt ttactttgtt
      961 cctccatcga agaactggaa gataagcaaa aacctacagc tgattcctct ccagacatta
     1021 gtctgttcct accaatgctt tgaccggcgt gatcctgatg tctttggaat tgctaaagaa
     1081 tagagcagga agaagagctc tcctgttggt ccatatctga agtggaagac agtcagaaaa
     1141 ccttttgatg tctataggtg ttcgctggac attcaaggct gagatggtcc atgtgggtgg
     1201 tatacattat tgaacatcaa agagccttca gtcactggaa ctttcaaata aatgttatta
     1261 atcttaaa
//
LOCUS       NM_001025755            1443 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus RIKEN cDNA 1700001E04 gene like (1700001E04Rikl),
            transcript variant 1, mRNA.
ACCESSION   NM_001025755 XM_006226670 XM_346229
VERSION     NM_001025755.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 26, 2024 this sequence version replaced NM_001025755.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000009.1  3108976-3109150
            176-335             JAXUCZ010000009.1  3109872-3110031
            336-467             JAXUCZ010000009.1  3111023-3111154
            468-651             JAXUCZ010000009.1  3111822-3112005
            652-1443            JAXUCZ010000009.1  3116314-3117105
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9"
     gene            1..1443
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /note="RIKEN cDNA 1700001E04 gene like"
                     /db_xref="GeneID:367620"
                     /db_xref="RGD:1560404"
     exon            1..175
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..657
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein LOC367620 isoform 1"
                     /protein_id="NP_001020926.1"
                     /db_xref="GeneID:367620"
                     /db_xref="RGD:1560404"
                     /translation="MFRQLLRLFRKESGDQGETTPRQKEDDLLSSKTGRRKSFWGRLG
                     FGRKTSSQNVISEQEKCRKELEELKLEIQKCKFERDELYQILDLYIYDDWDLRLDVEL
                     PILQSEHERRMMSMQMMTNSISDAMERYKELIQANSSYRIRHSQLLREQAQLKNKIQI
                     LLNEKREQLVEQTELPASYVEAKRLCEEAGMNICVPSAKQQQV"
     misc_feature    184..426
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     misc_feature    184..426
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /note="Region: Takusan; pfam04822"
                     /db_xref="CDD:461445"
     exon            176..335
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /inference="alignment:Splign:2.1.0"
     exon            336..467
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /inference="alignment:Splign:2.1.0"
     exon            468..651
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1443
                     /gene="1700001E04Rikl"
                     /gene_synonym="RGD1563862"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttggga tattccttca gttccctttg ggttcacaag caggcatgtt tcgccagctg
       61 ctcaggctat ttcgcaagga aagtggagat caaggagaga ccacaccaag gcagaaggaa
      121 gatgacctcc tctctagtaa aacaggaagg aggaaatcat tctggggaag gcttggattt
      181 ggtaggaaga catcatccca aaatgtcatc agtgagcaag agaagtgtcg aaaggaactg
      241 gaggaactca aacttgaaat ccagaagtgt aaattcgaga gggatgaact ttatcaaatc
      301 ctggaccttt atatctatga tgattgggac ctcaggctgg atgtcgaatt gccaatactt
      361 caatccgaac atgagaggag aatgatgtct atgcaaatga tgaccaactc aataagtgat
      421 gccatggaga ggtacaagga gctcatacaa gcgaacagtt cctaccgcat caggcactcc
      481 cagctcctgc gtgaacaagc tcaattgaag aacaaaatac agattttgct gaatgagaag
      541 agagaacagc tggtggagca gactgaactg ccagcatcct atgtggaggc aaagaggctc
      601 tgtgaagagg ccggaatgaa catctgtgtc cccagtgcca agcaacagca ggtttgaaat
      661 tctccagcag aaactcaaac atgacataga ccaggacaag atctcccttg gtgagaagtg
      721 gtacaggagg agcgctaagt gtgcacagca aatacaccac tattgcatct catctgtaat
      781 gtccatagca attgtggact gcattttcct cctttagttt gatttctttg gattgaatag
      841 gctgtacttt cacctcgcct ctctccagca agtgtacagt tttggaggga cccagagaag
      901 tgctgatgca catcaatcaa gagctgctgg tcatccagaa agactgtgca cgtgtaaatt
      961 tgtacttgtc ctgatgggtc atccaaaagg gtttcatgga gatcagttca caacattgga
     1021 aagactttga gacaaagact gtgatgtatt ttatgctcgg tattggatgg tcttgtcctt
     1081 cataccccac tccaatagaa gagacctcct tacattccgc ttgaaaagat tattaccatc
     1141 agtaactgct tatctattat gttccaaggc caactacggg gtataaatct gttctgcaga
     1201 atgaatagca aaagaatgtt tagcacaatt cctctgttta gattttggtt tgagttttga
     1261 ttattttggt tctttggttt ttcttgtatt catttgaaag tttgttattt atttgttttt
     1321 gttttattct tacagttgat tcgctatttt gataaggata tagactgtat atattgacta
     1381 cccacatctg gttactattg agtaaactgg atgtattctt ttaaataaaa cagtgatctc
     1441 aaa
//
LOCUS       NM_053499               1552 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus mitochondrial transcription termination factor 1
            (Mterf1), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_053499
VERSION     NM_053499.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Yakubovskaya,E., Mejia,E., Byrnes,J., Hambardjieva,E. and
            Garcia-Diaz,M.
  TITLE     Helix unwinding and base flipping enable human MTERF1 to terminate
            mitochondrial transcription
  JOURNAL   Cell 141 (6), 982-993 (2010)
   PUBMED   20550934
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Li,X., Zhang,L.S. and Guan,M.X.
  TITLE     Cloning and characterization of mouse mTERF encoding a
            mitochondrial transcriptional termination factor
  JOURNAL   Biochem Biophys Res Commun 326 (2), 505-510 (2005)
   PUBMED   15582606
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Prieto-Martin,A., Montoya,J. and Martinez-Azorin,F.
  TITLE     Phosphorylation of rat mitochondrial transcription termination
            factor (mTERF) is required for transcription termination but not
            for binding to DNA
  JOURNAL   Nucleic Acids Res 32 (7), 2059-2068 (2004)
   PUBMED   15087485
  REMARK    GeneRIF: The DNA-binding activity of mTERF is unaffected by the
            phosphorylation or dephosphorylation state, however, only the
            phosphorylated form of the protein is active for termination
            activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Enriquez,J.A., Fernandez-Silva,P., Garrido-Perez,N.,
            Lopez-Perez,M.J., Perez-Martos,A. and Montoya,J.
  TITLE     Direct regulation of mitochondrial RNA synthesis by thyroid hormone
  JOURNAL   Mol Cell Biol 19 (1), 657-670 (1999)
   PUBMED   9858589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 20, 2024 this sequence version replaced NM_053499.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ292524.1, SRR26360181.1434548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000004.1  31181083-31181217
            136-263             JAXUCZ010000004.1  31182646-31182773
            264-1552            JAXUCZ010000004.1  31186842-31188130
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1552
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="mitochondrial transcription termination factor 1"
                     /db_xref="GeneID:85261"
                     /db_xref="RGD:621318"
     exon            1..135
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     exon            136..263
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1552
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    268..270
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="upstream in-frame stop codon"
     CDS             295..1419
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /function="mitochondrial transcription termination"
                     /note="transcription termination factor, mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 1,
                     mitochondrial"
                     /protein_id="NP_445951.2"
                     /db_xref="GeneID:85261"
                     /db_xref="RGD:621318"
                     /translation="MASRNIWRVRRNFLFDLRGWVPQYSAEVFLKSISFRPFSVECNS
                     KDGENGDLLNNLLTMGVDVDMARRRQPGVFNRAVTNEQELKMFLLSKGASDKVIGSII
                     SRYPRAITRTPESLSKRWDLWREIMASDLEIVNILERSPESFFRSNNNLNLENNIKFL
                     CSVGLTHKCLCRLLTSAPRTFSNSLNLNKQMVEFLQETGISLGHNNPTDFVRKIISKN
                     PSILIQSTKRVKTNIEFLQSTFNLDKEDLLLLICGPGARILDLSNDCTKRNYTNIKKR
                     LLSLGCTEEEVQKFVLSYLNMIFLSEKKFNDKIDCLLEEKISTSQILENPRVLDSSIH
                     TLKTRIRELAHAGYDVSTSSIALLSWSQRRYEAKLKRLSG"
     transit_peptide 295..405
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9EPI8.1)"
     mat_peptide     406..1416
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /product="transcription termination factor 1,
                     mitochondrial"
     misc_feature    451..1392
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Region: mTERF; pfam02536"
                     /db_xref="CDD:460581"
     misc_feature    451..1392
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Region: mTERF; pfam02536"
                     /db_xref="CDD:460581"
     misc_feature    709..711
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9EPI8.1); other
                     site"
     misc_feature    730..735
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI8.1);
                     Region: Interaction with DNA. /evidence=ECO:0000250"
     misc_feature    829..831
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9EPI8.1); other
                     site"
     misc_feature    964..978
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI8.1);
                     Region: Interaction with DNA. /evidence=ECO:0000250"
     misc_feature    1195..1218
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI8.1);
                     Region: Interaction with DNA. /evidence=ECO:0000250"
     misc_feature    1273..1275
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="Interaction with DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9EPI8.1); other
                     site"
     misc_feature    1288..1299
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI8.1);
                     Region: Interaction with DNA. /evidence=ECO:0000250"
     misc_feature    1375..1398
                     /gene="Mterf1"
                     /gene_synonym="Mterf"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI8.1);
                     Region: Interaction with DNA. /evidence=ECO:0000250"
ORIGIN      
        1 gccctcctat tccttccttg gcgtgtaggg gcagaagtaa aaggcggaag taaaaggtgt
       61 ctaccgcgag ctttggtacc ggacgcgaat acaaagttga gttcaggctg gggttggaga
      121 gacgctgtac cgttggattt ctcttgaatg ttctgtggat gttcatctgt ctaccatgat
      181 gctaagcatc tgaagagaac gcactgtata gggtagtaat ctttaaccct aaaggcttcg
      241 tatgtgtatg gcttttatgt atggacttga aaagctttgg actatcctgt gataatggca
      301 tcaagaaaca tctggcgtgt gagaaggaac ttcctctttg atttaagagg ttgggtgccc
      361 caatattcag cagaagtttt cctcaagtcg atttcattca ggccttttag tgtggaatgt
      421 aacagtaaag acggggagaa tggggaccta ctcaacaact tactcaccat gggagttgat
      481 gtcgacatgg caaggagacg acagcctgga gtttttaaca gggctgtcac gaatgagcag
      541 gagctgaaga tgttccttct gtccaaagga gcaagtgaca aagtgattgg tagcatcata
      601 tcaagatatc cacgagccat aacacgcact cctgaaagtc tttcaaaacg gtgggatctg
      661 tggagagaga ttatggcatc agaccttgaa attgtaaata ttttggagcg ttctcctgaa
      721 tccttctttc ggtctaataa caacctaaac ttagagaata acataaagtt cctctgctct
      781 gttgggttga ctcataagtg cctctgccga ctgttgacca gtgctcccag gaccttctcc
      841 aacagtctga atttgaataa acaaatggtt gaatttttgc aggagaccgg tatatcctta
      901 ggtcacaata atcccacaga ttttgtcagg aagataattt ctaaaaatcc ttccatctta
      961 attcagagca ccaaacgtgt gaaaactaac attgaatttt tacagtcaac tttcaactta
     1021 gacaaagagg acctgctgct tctgatatgt ggtccaggag ctagaatctt agacctttcc
     1081 aacgactgta ccaaaagaaa ctacacaaac atcaaaaaga ggctgctctc tctcggatgc
     1141 actgaggagg aggtacagaa gtttgtccta agctatctga atatgatctt cttgtcagag
     1201 aaaaagttca atgataaaat agactgcctc ctagaagaga aaatcagtac ttcacaaata
     1261 cttgaaaatc caagggtatt agactcgagc atacatactt taaaaactcg catcagagag
     1321 ttggcacatg ctggatatga cgtgagcacc tcaagcattg ctctgctgtc ctggagtcag
     1381 agacgatatg aagctaaact gaagagatta agtgggtagg ccagtgcagg cggagtcacc
     1441 aggaatcttg caagtagagt gctggttcca gtttggactt ttcaaacagg agagattttt
     1501 ttaaataatt tttttactta aatcatttaa ataaatattt taaaatattt aa
//
LOCUS       NM_001107492            1812 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 8 (B3gnt8), transcript
            variant 2, mRNA.
ACCESSION   NM_001107492 XM_001069916 XM_218342
VERSION     NM_001107492.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Ishida,H., Togayachi,A., Sakai,T., Iwai,T., Hiruma,T., Sato,T.,
            Okubo,R., Inaba,N., Kudo,T., Gotoh,M., Shoda,J., Tanaka,N. and
            Narimatsu,H.
  TITLE     A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which
            synthesizes poly-N-acetyllactosamine, is dramatically upregulated
            in colon cancer
  JOURNAL   FEBS Lett 579 (1), 71-78 (2005)
   PUBMED   15620693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001069916.1, XM_218342.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB718954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132308
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1812
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /db_xref="GeneID:308440"
                     /db_xref="RGD:1305374"
     exon            1..227
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     exon            228..451
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    409..411
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="upstream in-frame stop codon"
     exon            452..1812
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..1653
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="UDP-Gal:betaGal beta 1,3-galactosyltransferase
                     polypeptide 7"
                     /codon_start=1
                     /product="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /protein_id="NP_001100962.1"
                     /db_xref="GeneID:308440"
                     /db_xref="RGD:1305374"
                     /translation="MRCRKCQLCLSALLTLLGLKVYIEWTSESWLKKAEPRGALPSPT
                     PPSAEPTLPTNLSARLGQTGPLSSAYWNQQQRQLGVLPSSDCQTWGSVAASEILDFIL
                     YPQDLRRFLLSAACRSFPLWLPAGEGSPVASCSDKDVPYLLLAVKSEPGHFAARQAVR
                     ETWGSPVAGTRLLFLLGSPLGMGGPDLTSLVTWESRRYGDLLLWDFLDVPYNRTLKDL
                     LLLTWLSHHCPKVSFVLQVQDNAFVHIPALLEHLQALPPTWARSLYLGEVFTQAKPLR
                     KPGGPFYVPKTFFEGDYPAYASGGGYVISGRLAPWLLQAAARVAPFPFDDVYTGFCFR
                     ALGLAPRAHPGFLTAWPAERTRDPCAVRGLLLVHPVSPQDTIWLWRHLWVPELRC"
     misc_feature    943..1506
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     misc_feature    943..1506
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
ORIGIN      
        1 ctaggctagg ctgggcttgg ccaggcctgg cccttggcta tcttcctcac tctagcccgt
       61 acttattcca ttaacgttca ccatttcctc cccactctct tcctccatct gttcccacgg
      121 gctccattat tcaaacttgg agggaggaaa tcggggctgg aaagataaca gactctggcc
      181 tctggtacac tgagttcctt ttatatctgg acagtcctcc aaaccagtct caccagaaaa
      241 ccagccctaa ctcgccagga cgcgtctccc tgtctgcctc cccttcccgg ccccgccccg
      301 gctcctcccg gccccagggg ccctctcgcc cgcccctcca gactcgcagc gcgggctggg
      361 ccggcagccg aggacgcaca gcttcgaaga gggagtccgg gcagagcttg acccgaggac
      421 cccccagagc tggcggaagc tggactcaga gccccaccag tggccctttc cctgggccgg
      481 gtcatgcgtt gccgcaagtg ccagctctgc ctgtcagcac tgctcacact cctgggcctc
      541 aaagtataca tcgagtggac atctgagtcc tggcttaaaa aggctgaacc ccggggcgct
      601 ctgcccagtc caacgccacc aagtgctgag cccaccttgc ccaccaacct ctcagcacgc
      661 ctgggtcaga ctggcccact gtcctctgct tattggaacc agcagcagcg gcaactgggc
      721 gtcctgccga gttcggactg tcagacttgg gggagtgttg ctgcctcaga gatcttggac
      781 ttcatcctgt acccccaaga ccttcggcgc ttcttgctgt cagcagcctg taggagcttc
      841 ccgctatggc tgcctgcagg agaaggcagc ccggtggcca gctgctctga taaggatgta
      901 ccctacttgc tactggctgt caaatcagaa ccaggacact ttgcagcaag gcaggctgtg
      961 agggagacct ggggcagccc agttgctggg acccggttac tcttcctgct ggggtcccca
     1021 ctaggaatgg gggggcctga cctaacatca ctggtgacgt gggagagccg gcgctatggt
     1081 gacctactgc tctgggactt cctggatgtt ccctacaacc ggacactgaa agacctgctg
     1141 ctgctgacct ggctgagcca ccactgcccc aaggtcagtt tcgtcctgca ggttcaggac
     1201 aatgcctttg tccacatccc agccctgctg gagcacctgc aggctctgcc acctacctgg
     1261 gcccgcagcc tctacctggg tgaggtcttc acccaggcca aaccacttcg caagcccgga
     1321 ggacccttct atgtgccgaa gaccttcttt gaaggtgact acccagccta tgcaagtggg
     1381 ggtggctacg tcatctcggg gcgcctggct ccctggctgc tgcaggcagc agcccgagta
     1441 gcgcccttcc cctttgatga tgtctacact ggtttctgct tccgtgccct gggcttagcg
     1501 ccccgtgccc atccaggctt cctcacagcc tggccagcag agcgtaccag ggacccctgc
     1561 gctgtacgag gcctgctgct ggtgcatcca gtcagccccc aggacaccat ttggctctgg
     1621 agacatctgt gggttccaga gctccggtgc tgatccccag agacaagctg gggtggtggt
     1681 gggggtgcgg gtgagggtgc tgacctggcc tgagtccctc ccaaaccctt cccagccaag
     1741 aatgggcagg ccagacaagg tggcagacta tgttcatcta ctttctgaat ttgaaaaagt
     1801 gtgtccttcc ta
//
LOCUS       NM_001437983            1494 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 87 (Gpr87), mRNA.
ACCESSION   NM_001437983 XM_063281787
VERSION     NM_001437983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 11, 2025 this sequence version replaced XM_063281787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.9075.1,
                                           SRR26643294.8887.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN13663597,
                                           SAMN13663603 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000002.1  145607864-145608092 c
            230-361             JAXUCZ010000002.1  145595208-145595339 c
            362-1494            JAXUCZ010000002.1  145589622-145590754 c
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1494
                     /gene="Gpr87"
                     /note="G protein-coupled receptor 87"
                     /db_xref="GeneID:310443"
                     /db_xref="RGD:1307852"
     exon            1..229
                     /gene="Gpr87"
                     /inference="alignment:Splign:2.1.0"
     exon            230..361
                     /gene="Gpr87"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    322..324
                     /gene="Gpr87"
                     /note="upstream in-frame stop codon"
     CDS             328..1404
                     /gene="Gpr87"
                     /codon_start=1
                     /product="G-protein coupled receptor 87"
                     /protein_id="NP_001424912.1"
                     /db_xref="GeneID:310443"
                     /db_xref="RGD:1307852"
                     /translation="MGLNLTLAKLPGNELYSQASHTANSTIEGHGKNSTHHNEFDTII
                     LPVLYLVIFVASILLNGLAVWIFFHIRNKTSFIFYLKNIVVADLIMTLTFPFRIVRDA
                     GFGPWYFEFILCRYTSVLFYANMYTSIVFLGLISVDRYLKVVKPFGDSRMYSITFTKV
                     LSICVWVIMAVLSLPNIILTNGQPTKENIHDCMKLKSPLGAKWDMAVTYVDSCLFVAV
                     LVILIGCYIAISRYIHKSSRQFISQSSRKRKHNQSIRVVVAVFFTCFLPYHLCRIPFT
                     FSHLDRLLDDSAHKILHYCKEMTLFLSACNVCLDPIIYFFMCKSFSRRLFKKSNIRTR
                     SESIRSLQSVRRSEVRIYYDYTDV"
     misc_feature    454..1302
                     /gene="Gpr87"
                     /note="G protein-coupled receptor 87, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR87; cd15969"
                     /db_xref="CDD:320635"
     misc_feature    454..1302
                     /gene="Gpr87"
                     /note="G protein-coupled receptor 87, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_GPR87; cd15969"
                     /db_xref="CDD:320635"
     misc_feature    454..537
                     /gene="Gpr87"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320635"
     misc_feature    454..537
                     /gene="Gpr87"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320635"
     misc_feature    553..630
                     /gene="Gpr87"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320635"
     misc_feature    553..630
                     /gene="Gpr87"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320635"
     misc_feature    order(655..657,667..669,679..684,691..696,703..705,
                     832..834,841..846,853..855,865..867,898..903,913..915,
                     937..939,946..951,958..960,1141..1143,1150..1152,
                     1162..1164,1213..1215)
                     /gene="Gpr87"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320635"
     misc_feature    order(655..657,667..669,679..684,691..696,703..705,
                     832..834,841..846,853..855,865..867,898..903,913..915,
                     937..939,946..951,958..960,1141..1143,1150..1152,
                     1162..1164,1213..1215)
                     /gene="Gpr87"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320635"
     misc_feature    667..759
                     /gene="Gpr87"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320635"
     misc_feature    667..759
                     /gene="Gpr87"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320635"
     misc_feature    793..861
                     /gene="Gpr87"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320635"
     misc_feature    793..861
                     /gene="Gpr87"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320635"
     misc_feature    934..1023
                     /gene="Gpr87"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320635"
     misc_feature    934..1023
                     /gene="Gpr87"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320635"
     misc_feature    1060..1152
                     /gene="Gpr87"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320635"
     misc_feature    1060..1152
                     /gene="Gpr87"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320635"
     misc_feature    1204..1281
                     /gene="Gpr87"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320635"
     misc_feature    1204..1281
                     /gene="Gpr87"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320635"
     exon            362..1494
                     /gene="Gpr87"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgttcat gggcagggcg gtttgaaagg tgccccaaag gacactcttc acaggtcggc
       61 agagcaccca ccgtcttctc gggcagaaca aagaaaatgc cggtttccat ctagaaaacc
      121 tgtattcttg ctaaccttag ttttgagatc tactcctgct taagagatga gagggagcct
      181 gattcaactt gaagacaagt gaacacccag ccgggcacca caatgaaaga aatcaaacca
      241 ggaataacct ttgctgaatc cgtgcctcac ctgtccctga atgtttcttg acatgcatct
      301 tgacttaccg tacatcacaa ctagagaatg gggctcaacc tgacgcttgc aaaattacca
      361 ggtaatgaat tatacagcca agcaagtcac actgcaaaca gcacgatcga gggacatggg
      421 aagaactcca cccatcacaa cgagtttgac accatcatcc tgccggtgct ttacctagtt
      481 atatttgtgg caagcatcct gctgaacggt ctggctgtgt ggatcttctt ccacattcgg
      541 aataaaacca gcttcatatt ttatctcaaa aatatagtag tagctgacct cataatgacc
      601 ctgacattcc cgttccgaat agtccgtgac gcaggattcg gaccttggta ctttgagttt
      661 atcctctgca gatacacctc ggttttgttc tatgcaaaca tgtatacatc cattgtgttt
      721 cttgggctga tcagtgttga tcgctatctg aaggtggtaa agccttttgg tgactctcgc
      781 atgtatagca taaccttcac caaagtctta tcgatttgtg tctgggtgat catggctgtt
      841 ctgtccttgc caaacatcat actgactaac ggtcaaccaa ctaaggaaaa cattcatgac
      901 tgcatgaagc ttaaaagtcc gttgggagcc aagtgggata tggctgtcac ctacgtggac
      961 agctgtctgt ttgtcgctgt gctggtgatt ctgattggat gctacatagc catctccaga
     1021 tacatccaca aatccagcag gcaattcata agtcaatcga gccggaagcg gaagcataac
     1081 cagagcatcc gcgtggtcgt ggctgtgttt tttacctgct tcctcccgta tcacttgtgc
     1141 agaatcccct tcactttcag tcacttagac aggctcctag atgactcagc acacaaaatt
     1201 ctccactact gcaaggaaat gacacttttc ttgtctgcgt gcaacgtgtg cctggatccg
     1261 ataatttatt ttttcatgtg taagtcattt tcaagaaggt tattcaagaa atcaaacata
     1321 agaaccagga gtgaaagcat caggtcgctg caaagcgtcc gaagatcaga agtgcgtatc
     1381 tactatgact acaccgatgt gtagggacta gaggccagag ggccttttcc tgttggaatc
     1441 agtatataaa agtgtaaata aatgtctctt tgtattattc tggctgaagc ctat
//
LOCUS       NM_001438008            3994 bp    mRNA    linear   ROD 16-APR-2025
DEFINITION  Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001438008 XM_063288190
VERSION     NM_001438008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3994)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   2  (bases 1 to 3994)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3994)
  AUTHORS   Lekva,T., Berg,J.P., Lyle,R., Heck,A., Ringstad,G., Olstad,O.K.,
            Michelsen,A.E., Casar-Borota,O., Bollerslev,J. and Ueland,T.
  TITLE     Epithelial splicing regulator protein 1 and alternative splicing in
            somatotroph adenomas
  JOURNAL   Endocrinology 154 (9), 3331-3343 (2013)
   PUBMED   23825128
  REMARK    GeneRIF: Data suggest that alternative splicing in ESRP1
            transcripts in somatotroph adenoma cells is essential in
            epithelial-mesenchymal transition progression and in response to
            somatostatin analog antineoplastic treatment.
REFERENCE   4  (bases 1 to 3994)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 14, 2025 this sequence version replaced XM_063288190.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18270.1,
                                           SRR22582416.813213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JAXUCZ010000005.1  29278875-29279380   c
            507-635             JAXUCZ010000005.1  29278248-29278376   c
            636-749             JAXUCZ010000005.1  29276909-29277022   c
            750-864             JAXUCZ010000005.1  29272117-29272231   c
            865-963             JAXUCZ010000005.1  29259227-29259325   c
            964-1018            JAXUCZ010000005.1  29259048-29259102   c
            1019-1129           JAXUCZ010000005.1  29257470-29257580   c
            1130-1262           JAXUCZ010000005.1  29257227-29257359   c
            1263-1305           JAXUCZ010000005.1  29257087-29257129   c
            1306-1607           JAXUCZ010000005.1  29253546-29253847   c
            1608-1826           JAXUCZ010000005.1  29252420-29252638   c
            1827-2025           JAXUCZ010000005.1  29250290-29250488   c
            2026-2194           JAXUCZ010000005.1  29246768-29246936   c
            2195-2345           JAXUCZ010000005.1  29237174-29237324   c
            2346-2457           JAXUCZ010000005.1  29231531-29231642   c
            2458-3994           JAXUCZ010000005.1  29224831-29226367   c
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3994
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
     exon            1..506
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="upstream in-frame stop codon"
     CDS             375..2420
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 35A; RNA-binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     1"
                     /protein_id="NP_001424937.1"
                     /db_xref="GeneID:500409"
                     /db_xref="RGD:1560481"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDLDKLDVAA
                     MAESLNFEKNDSMSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKT
                     ELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKD
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTAPIIPVLPQQFVPPTNVRDCVRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVI
                     PTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANL
                     SSVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLVHTNDQARTLPKEWVCI"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    459..878
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; Region: DnaQ_like_exo; cl10012"
                     /db_xref="CDD:447876"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1298
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1302..1634
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; Region: RRM2_ESRP1; cd12739"
                     /db_xref="CDD:410136"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    1704..1946
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; Region: RRM3_ESRP1_ESRP2; cd12742"
                     /db_xref="CDD:410138"
     misc_feature    2001..2003
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); phosphorylation site"
     misc_feature    2118..2120
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (B2RYD2.2); methylation site"
     misc_feature    2271..>2390
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    2271..>2390
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     exon            507..635
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            750..864
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1018
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1129
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1262
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1305
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1607
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1826
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2025
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2194
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2345
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2457
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..3994
                     /gene="Esrp1"
                     /gene_synonym="RGD1560481"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggga aaaggggcgg gcaggtagag ccacatccca aaacagaaaa gctttcagcc
       61 attgcgcgcg cctcccgggg gtgcagcccg gctcctgggg tttttttttc ttagacgcac
      121 gagcaattgg atacaaaaag ggcaggcctg ctgctccctc cttccacccc cccttcctgc
      181 ccagggtgtg gagcgccggc caggtgcggg cttgggtggc aggttaccgc cttttgccct
      241 ggcggcctcg aggagggggg tgggcgcttt ctttttctct tggaagaggg ttttagcaca
      301 ggttttctcg ttctcacttc caaccccacc tcgccgcctc ccgacccccc tcctcccctt
      361 ccccacctat cgtcatgacg gcgtctccgg attacttggt ggtgcttttt gggatcactg
      421 ctggggccac aggagccaag ctgggttcgg atgagaagga gctgatcctg ctgttatgga
      481 aagtcgtgga tttggccaac aagaaggtgg gacagttgca cgaagtacta gttagaccgg
      541 atcagttgga actgacagag gattgtaaag aagaaactaa aatagacgcc gaaaatctgt
      601 cttccgcccc gcagctggac caagccctcc gacagtttaa ccagtcagtg agcaatgaac
      661 tgaacattgg ggtagggact tccttctgtc tgtgtactga cgggcagctt cacgtcaggc
      721 agatcttgca tcccgaggct tccaagaaga atgtattact acctgaatgc ttctattcct
      781 ttttcgatct tcgaaaagaa ttcaagaagt gttgccccgg ctctcctgac ctcgacaagc
      841 tggatgttgc agccatggca gagagcctaa actttgagaa gaatgactcc atgtccagat
      901 acggagcctc ccaagttgaa gacatgggga acataatttt agcgatgatc tcagagccct
      961 acaatcacag attttcagat ccagagagag taaactacaa atttgaaagt ggcacttgca
     1021 gcaagacgga gcttatcgat ggcaacacgg tggtgagggc tcgaggtttg ccctggcagt
     1081 cttcagatca agatattgca aggttcttca aaggactcaa tattgccaag ggtggtgcag
     1141 ctctttgtct gaatgctcag gggcggagga acggggaagc tctggttaga tttgtaagtg
     1201 aggagcacag agatctggcc ctgcagaggc acaaacatca tatggggacc cgttacatcg
     1261 aggtttacaa agcaacaggc gaagactttc ttaaaattgc cggagggaca tccaatgagg
     1321 tggcccagtt tctctccaag gaaaaccaag tcatcgtgcg catgcggggg ctccctttca
     1381 cagccacggc ggaagaagtg gtagccttct ttggacagca ctgccctatc actgggggga
     1441 aggaaggcat cctcttcgtc acctacccag atggtaggcc cacgggagat gcttttgtgc
     1501 tctttgcttg tgaggagtat gctcagaacg ccctgaggaa gcacaaggac ttgttgggta
     1561 aaagatacat cgagctcttc agaagcacag cagctgaagt tcagcaggtg ctgaatcggt
     1621 tctcctccgc tcctttgatt ccacttccca ccgctcccat catccctgtg ctacctcagc
     1681 agtttgtgcc ccccacaaat gtaagagact gcgtacgtct gcgaggtctt ccctatgccg
     1741 ccaccataga agacattctg gacttcctgg gggagttttc cacagacatt cgtacgcatg
     1801 gggttcacat ggtattgaac caccagggac gcccgtcagg agatgccttt atccagatga
     1861 agtctacaga cagagcattc atggctgcgc agaagtatca taaaaaaacc atgaaggaca
     1921 gatatgttga agtctttcag tgttcagctg aggagatgaa ctttgtgtta atggggggca
     1981 ctttaaatcg aaatggctta tccccaccgc catgtaagtt accatgcctg tctcctccct
     2041 cctacacatt cccagctcct gcagccgtga ttcctaccga agctgccatt tatcagcctt
     2101 ccctgctctt gaacccacgg gcactgcagc cctccactgc ttactaccca gcaggcactc
     2161 agctgttcat gaactacaca gcctactatc ccagcccccc aggttcgcct aatagtcttg
     2221 gctacttccc tacagctgct aatcttagca gtgtcccgcc ccagcctggc acggtggtca
     2281 gaatgcaggg cctggcctac aatactggag ttaaggaaat tcttaacttc ttccaaggtt
     2341 accagtatgc aaccgaggat ggacttgtac acacaaatga ccaggccagg actctaccca
     2401 aagaatgggt ttgtatttaa gggccccagc agttagatcg tcctcagaga aaagaagtgt
     2461 ttgaaagacg catggtgatc ctgaaactat cagacgagaa cttctagcaa tttcagggga
     2521 tgtttgtcta cactcaggct gcggaagttt cagccaacgg attggacagt gggcctgggc
     2581 cttatctttt ggtggagtga aaaaacgtgg agccgtggaa gccaaatctt tatagcaagc
     2641 agtgtgcacg aacctggctc cttgctgagt gcaaatagga atttaaatgt gaatttgaag
     2701 tcaaagttct cacttccagc taactggcaa catttatttc ctgagctgaa gtcttggagt
     2761 aaaatacatt ccagtagcat ctaccatcca ccattaattg ctatggaagc ctcattgtgt
     2821 accccactct tctgtctccc tgttttctgt aaaataaaac cctcttgcta agtaatttaa
     2881 gtgtacgttc ttagaatact taagtcccaa actaaagaaa aggaataaaa taaaattaat
     2941 attttcccaa atactagttt tcttcaatag gccatcatgg tgccttattg ttaacaacaa
     3001 atatttctaa aatgtctcag gcaggctggg cccatctccg tggtaaagag cttgcctgcc
     3061 tagcacactt gagccctggg tttgcagacc tatcccctgt gtcctctcca cagtgcgccc
     3121 ttccacacgc gccttgttaa aggccttgct gcgtgttttt ctctgcaggt atccgctgta
     3181 aataagaatg aagtaggggc caaaacctga aaccaaaaat gaagcagctc cttgtagtct
     3241 tagttcctag tttgagctgt agctgactgc ttggcttccc gtgtattatt ttatattgtg
     3301 cttttgtcat tgttaatggt ttggacttta ataagagaaa tcccatagtt tttaatgtca
     3361 caaaaataag cctatttgaa cagtgtattc cagaaagcaa tatactaacc aaagtgaatg
     3421 cttgtgtgta ttgataccct tttcctctct aacgcctcaa ctgtcaagga actaaaacct
     3481 ttaaaagcat aggcatgctg gcctgaggta aacactggta cagttagagc ggaggcagca
     3541 gcccccggtg ttcagcacag cttgtctgat gtgtttatgg ccagagtgca gtattcggca
     3601 ctggctagta ccgctgcctg accgaactcc actgggaagt ggtttgctta aacgcacatg
     3661 tttctttgtt actcctgacc atgcttggat gcagtgccta gattgtggct gctattttta
     3721 gttcgcatca tgaccttgac tgcggagtcc agccttaccc tcttacttga caacagtagc
     3781 ccttaaactg cagtgggaag aaagaagaat ttggtatgaa aattggtgag ctctggcact
     3841 tgagataaac aagaagaaag ttccaacttg atgccttaag ccgctcctgc ccgaagctct
     3901 gaaggactaa gttggcagag atccttactt tgatactact gcattttttg tagaattgtt
     3961 acattgataa taaaacttgc ctgcttaacc tcaa
//
LOCUS       NM_001438325            1477 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus StAR-related lipid transfer domain containing 10
            (Stard10), transcript variant 3, mRNA.
ACCESSION   NM_001438325
VERSION     NM_001438325.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Ito,M., Yamanashi,Y., Toyoda,Y., Izumi-Nakaseko,H., Oda,S.,
            Sugiyama,A., Kuroda,M., Suzuki,H., Takada,T. and Adachi-Akahane,S.
  TITLE     Disruption of Stard10 gene alters the PPARalpha-mediated bile acid
            homeostasis
  JOURNAL   Biochim Biophys Acta 1831 (2), 459-468 (2013)
   PUBMED   23200860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.232791.1, EV780436.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-643               JAXUCZ010000001.1  165134668-165135310
            644-791             JAXUCZ010000001.1  165155405-165155552
            792-895             JAXUCZ010000001.1  165156043-165156146
            896-1013            JAXUCZ010000001.1  165156758-165156875
            1014-1066           JAXUCZ010000001.1  165158462-165158514
            1067-1477           JAXUCZ010000001.1  165158724-165159134
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1477
                     /gene="Stard10"
                     /note="StAR-related lipid transfer domain containing 10"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
     exon            1..643
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    287..289
                     /gene="Stard10"
                     /note="upstream in-frame stop codon"
     CDS             437..1309
                     /gene="Stard10"
                     /note="isoform 1 is encoded by transcript variant 3; START
                     domain containing 10; PCTP-like protein; StAR-related
                     lipid transfer (START) domain containing 10; START
                     domain-containing protein 10"
                     /codon_start=1
                     /product="START domain-containing protein 10 isoform 1"
                     /protein_id="NP_001425254.1"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
                     /translation="MEKPAASTEPQGPRPALGRESVQVPDDQDFRSFRSECEAEVGWN
                     LTYSKAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIET
                     FDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKD
                     LVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKA
                     CIKYPEWKQKHQPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVTESREERA
                     GGAGEGSDDDTSLT"
     misc_feature    491..1159
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    491..1159
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    order(572..577,596..598,638..640,644..646,680..682,
                     692..694,710..712,719..724,728..733,788..790,794..805,
                     809..811,818..820,824..826,830..832,875..877,926..928,
                     932..943,947..949,983..985,989..991,995..997,1001..1003,
                     1007..1009,1013..1015,1034..1036,1040..1048,1052..1060,
                     1067..1072,1079..1081)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     misc_feature    order(572..577,596..598,638..640,644..646,680..682,
                     692..694,710..712,719..724,728..733,788..790,794..805,
                     809..811,818..820,824..826,830..832,875..877,926..928,
                     932..943,947..949,983..985,989..991,995..997,1001..1003,
                     1007..1009,1013..1015,1034..1036,1040..1048,1052..1060,
                     1067..1072,1079..1081)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     exon            644..791
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            792..895
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1013
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1066
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1477
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccccgc gcagcttgct gccgagttag ttgtgcgagt ccggccagca ccgcgcgggg
       61 actccgtgcc agacccgcac ctgcgatccc cagagtcccg cccggctctc gcgggctcct
      121 gcacccgcta cgcagcaacc ctactgccgc tccagggaag tatgaggtcg ctccttgtgg
      181 gagggtggtg actgtcctgt gccggtgcac aaccgcctgg ggccagtacc tgcccttcta
      241 aagctgtccg ctggtccggg accccggcta gccccacccg cgcccctagc gcactgactc
      301 tggtccccaa accggtcttg caggtcccag gaaggtggcg tcagcatctg cagccgcgcc
      361 gacgttgtct gagcctccgc ggaggaccca ggagagtcgg actaggacca gggccccggg
      421 cctccccacg ctctctatgg aaaagccagc tgcttcaaca gaaccccaag ggcctcggcc
      481 cgctttgggc cgtgaaagtg tccaggtgcc cgatgaccag gacttccgca gttttcggtc
      541 agagtgtgag gccgaggtgg gctggaacct gacctacagc aaggccggtg tgtctgtgtg
      601 ggtgcaggct gtggagatgg atcgaactct gcacaagatc aagtgcagga tggaatgctg
      661 tgacgtacca gctgagacgc tctacgatgt cctgcacgac atagaatacc gaaagaagtg
      721 ggacagtaat gtcatcgaga cattcgacat cgctcgactg actgtcaacg ctgacgtagg
      781 atattactcc tggaggtgtc ccaagcccct gaagaaccgt gatgtcatca ccctccgctc
      841 ctggctcccc atgggcgctg attacatcat tatgaactac tcagtgaaac accctaaata
      901 cccacctcgg aaagacttgg tccgagctgt gtccatccag acgggctacc tcatccagag
      961 cacggggccc aagagctgtg tcatcaccta cctggcccaa gtggacccca aaggctcctt
     1021 acccaagtgg gtggtgaata agtcatctca gttcctggcc cccaaggcca tgaagaagat
     1081 gtacaaggcc tgcatcaagt accctgagtg gaagcagaaa caccagccac atttcaagcc
     1141 atggctgcac ccggagcaga gcccgttacc cagcctggcg ctgtcagagc tgtcggtgca
     1201 acacgcagac tcactggaga acatcgacga gagcgccgtg acagagagcc gggaggagcg
     1261 ggcgggtgga gcaggagagg gcagcgatga cgacacctcg ctcacctgag aaccgcctct
     1321 cttcaaggac caagacagga ctggggtgga accctggggc actgagcctt ctgcacttcc
     1381 tcccttcccc cacctgcctt ttgggggcac tgggctcctg ctcaggtggc tgcggcatgg
     1441 ctggacatgg ccccaataaa tgaaccacac agcccca
//
LOCUS       NM_001438259            5074 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 4, mRNA.
ACCESSION   NM_001438259 XM_063282789
VERSION     NM_001438259.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5074)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 5074)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 5074)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 5074)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 5074)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 5074)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 5074)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 5074)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282789.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2637327.1,
                                           SRR26643293.9502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000001.1  265880993-265881212
            221-283             JAXUCZ010000001.1  265883848-265883910
            284-616             JAXUCZ010000001.1  265885603-265885935
            617-672             JAXUCZ010000001.1  265888925-265888980
            673-817             JAXUCZ010000001.1  265892382-265892526
            818-923             JAXUCZ010000001.1  265893680-265893785
            924-987             JAXUCZ010000001.1  265896331-265896394
            988-1092            JAXUCZ010000001.1  265897265-265897369
            1093-1275           JAXUCZ010000001.1  265897587-265897769
            1276-1419           JAXUCZ010000001.1  265898203-265898346
            1420-1591           JAXUCZ010000001.1  265898771-265898942
            1592-1678           JAXUCZ010000001.1  265899871-265899957
            1679-1846           JAXUCZ010000001.1  265902762-265902929
            1847-1954           JAXUCZ010000001.1  265903044-265903151
            1955-2125           JAXUCZ010000001.1  265903930-265904100
            2126-2368           JAXUCZ010000001.1  265905270-265905512
            2369-2506           JAXUCZ010000001.1  265905824-265905961
            2507-2617           JAXUCZ010000001.1  265908907-265909017
            2618-2788           JAXUCZ010000001.1  265909555-265909725
            2789-3061           JAXUCZ010000001.1  265912578-265912850
            3062-3181           JAXUCZ010000001.1  265914596-265914715
            3182-3298           JAXUCZ010000001.1  265915981-265916097
            3299-3466           JAXUCZ010000001.1  265918673-265918840
            3467-3694           JAXUCZ010000001.1  265920045-265920272
            3695-3741           JAXUCZ010000001.1  265920791-265920837
            3742-3834           JAXUCZ010000001.1  265920914-265921006
            3835-5074           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..5074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..5074
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..220
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..283
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..616
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    298..300
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             313..3834
                     /gene="Tdrd1"
                     /note="isoform 1 is encoded by transcript variant 4; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 1"
                     /protein_id="NP_001425188.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSR
                     VQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNV
                     HAVSVEKCSENGMINIAENLVMCGLAENLSSKRESASTKETPHSTDCCCTELQKQIEK
                     HEQILLFLLNNPTNQNKFIEMKKLLQS"
     misc_feature    796..906
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    796..906
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1093..1482
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    1093..1482
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1261..1263,1282..1284,1336..1338,1345..1347,
                     1351..1353)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1261..1263,1282..1284,1336..1338,1345..1347,
                     1351..1353)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1843..2088
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1843..2088
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1948..1950,1969..1971,2020..2022,2029..2031,
                     2035..2037)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1948..1950,1969..1971,2020..2022,2029..2031,
                     2035..2037)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2434..2784
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2434..2784
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    3121..3468
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    3121..3468
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    order(3292..3294,3307..3309,3313..3315,3361..3363,
                     3370..3372,3376..3378)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     misc_feature    order(3292..3294,3307..3309,3313..3315,3361..3363,
                     3370..3372,3376..3378)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     exon            617..672
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..817
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..923
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..987
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1092
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1275
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1419
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1591
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1678
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1846
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1954
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2125
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2368
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2506
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2617
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2788
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3061
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3181
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3298
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3466
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3694
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3741
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3834
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..5074
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgaggcg aggtgagcac gggtgaagct cttggacttc ggggctgcgg ggtatggcaa
       61 acaccggcgt gagtgattag ccttagagac cgatcagggc cagcgccctt tcgccttttt
      121 ctgggtcagg cggcctggtc gccaaggcgc gggagctcgg tgtcaagatc gcctcgggcg
      181 tggatcgtta ggagccggaa gtccagagct ggacgttgag gtgaaggcag cactggatgt
      241 ctgagcgttt gcaggtcaac acatgagtaa gagttgcaaa aagacgtcag tgaatgttaa
      301 gttacatcta atatgatgcc acgaaataat ttggaagcct ctacttgtaa aatggcagaa
      361 ccatttaatt ttgagaaaaa ggaaagcaaa cttccacccc acgattctct aagaagtcct
      421 gtaccacagc ataaccatcc caatttcaga ctgaaaagcc cagagaacgg aaataaaaag
      481 aacaattttt tgctttgtga acaaaacaaa cagtacttgg ctagtcagga agacaattcg
      541 gtggtctctt caaaccctgc tggtatcaat ggagaagtag gtgggtccaa aggagacagg
      601 aagacattac caacaggaaa cccagtatca ttaagtcttg gaaacaattc accacctaac
      661 caagtaaaaa ctaagcccag caatgctgtg actcctgaaa aatcaaaaaa atctcacaag
      721 ctgtttgaga atgccttgtc cgtaaataac ccagctctct tcaactcgtt aggaccgccc
      781 ctgcggtcca caacctgcca tcgctgtggc ctgttcgggt cgctgaggtg ttcccagtgc
      841 aagcagacat attactgctc cacagcatgc cagaggagag actggtcttc ccatagcacc
      901 atctgtagac ctgtgcagca aagtctgcat aagcttgaag ataataagtc accatttgaa
      961 acaaagacca ttgacgtgaa gaatgaggtt gcctgtcccc tgggagttac taaagaaatg
     1021 acagctggtg cagagagagt aatgttttct gatctgagga gtctccaact gaggaaatcc
     1081 atggaaataa agggcacagt tactgaattc aagcacccgg gtcattttta tgtccagttg
     1141 tattcctcag aggttttaga gtacatgaac caactctctg caagtttgaa agagacatat
     1201 gcaaatatgg tgcctgaaga cggatatctt cctgttaagg gggaagtctg tgttgccaag
     1261 tacacggttg atcagacctg gaaccgagcc gtagtagaag gcgtggacgt gctgcagaag
     1321 aaggcacatg tcttgtacat cgactacgga aatgaagaga tcatcccagt cgacagaatc
     1381 caccagctaa gcagaagtat cagcctgttt cccccttccg ccataaagtg ctatgtgtca
     1441 ggagtcgtcc ccgctgcggg tgagtggact gaagactgtg ttgtagctgt caaggctctg
     1501 ctgttcgagc agtactgctc tatcaaggtc gtggacatct cagaggagga ggggctcacc
     1561 tgtgctgtcg acgtcgtgct gcagagttca ggaaaacagc tggaccatgt gcttgtggaa
     1621 atgggatatg gtgtgaaacc tgatgagccg agctccaaga agcaaagtat ggacccaggc
     1681 acttcggagg acactggaag actgacagct gagaacagga tcggggcaga gagaaatgcc
     1741 ctggtcccca cagtgctgac tttgaatgtg ggtgacgagt tctgtggtgt agttgcccac
     1801 atccagacac cagaggactt cttttgtcag cagctgcaga gtggccacaa gctcgccgag
     1861 cttcaggagt ccctcagtga gtactgtagc cacgtgactc cacgctcaga cttttatcca
     1921 accattgggg acatgtgttg tgctcagttc tcagaggatg accaatggta ccgcgcctcg
     1981 gttctggcct atgcttcaga agaatctgtc ctggttggat atgtcgatta tggaaacttt
     2041 gaaattctta gtttgaaaag actttgtccc ataattccaa agttgttgga tttgccgatg
     2101 caagctttaa attgtgtgct ggcaggagtg aagccatctt taggaatgtg gactccagaa
     2161 gccatttgtg tcatgaggaa ggctgtgcag aacaggatgg tgaccgtgag agtggtgggc
     2221 atgcagggga ccagggccct ggtggagctc gtagacaaat cggtggctcc tcacctcagc
     2281 gcttctaaag ctctgctaga ctccggcttt gccatcgagg aaaaggacat agtggcagat
     2341 aaaggcagca gtgcgcgtgc ctcgaatgtt cccttggctg tagaaggagc agtggaggtg
     2401 ctggagtgga cgtgggtcga gttcaccgtt gacgagactg tggacgtgat ggtctgcatg
     2461 atgcacagcc ctggggagtt ctactgccac tgtctcaaag acgacgcctt aaagaagctc
     2521 gatgacttga acaagtcctt agcagactac tgtgcacaaa aaccgcccaa tggcttcaag
     2581 gcagaggtag ggcggccttg ctgtgcctgt tttgcaggtg acggcaactg gtaccgggct
     2641 ctggtcaagg agatcctacc aagtgggaac gtcaaagtac actttgtgga ctacggcaat
     2701 gttgaagagg ttaccacaga ccaactgcac gcaatagccc cccagttctt actacttccg
     2761 ttccaaggga tgcagtgctg gctagtagat atacagccca aaaacaagca ttggacaaaa
     2821 gaagccacag caagatttca agcatgtgtc gtggggctta aacttcaagc cagagttgtg
     2881 gaaatcacgg agaatggggt gggcgttgaa ctcaccgatc tttccacccc ctaccccaaa
     2941 atcattagtg acgttctcat cacagaacat ctggtcttaa ggtgtggttc accacagaag
     3001 gacgagttga tgagcagacc tgctaataaa cataaccaga tcgactccca gagcgtgcaa
     3061 gccagccctc ctgcagagca gtggaagacc atagagttgc cagttaacaa gactgtacca
     3121 gcaaatgtac tagaaatcat aagcccaacc ttgttttatg ccatccccag tgaaatgcca
     3181 gaaaatcaag aaaaactgtg tgtgttgaca gctgaattgt tagaacactg taacgctcag
     3241 aaaggccagc caccctacag accacggacg ggagaagcct gctgtgctaa atacacaaat
     3301 gatgacttct ggtaccgggc cattgttctg gaagcgtcag actctgatgt gaaagttctc
     3361 tatgcagatt atggaaacgt ggaaagactg cctttttcca gagtgcagcc catcactgcc
     3421 agccacctgc agctgccctt ccgcatcatt agatgctcac ttgaggggct gacggagctg
     3481 aacggaagca gttcgcagcc agtgatggag ctgctgagga acgccatgct gaaccagagt
     3541 gtggctctct ctgtgaaagc agtctcgaag aatgtccatg cagtgtcagt tgaaaaatgt
     3601 tctgaaaatg gaatgatcaa tatagctgag aatctggtga tgtgtggcct ggcagaaaac
     3661 ctctcatcta aaagggaaag tgcttcaact aaagaaacac cgcacagcac cgattgctgc
     3721 tgcacagagt tacagaaaca gattgagaaa cacgaacaga ttctcctctt cctcttaaac
     3781 aatccaacca accaaaataa atttatagag atgaaaaagc tgctgcaaag ctaaaaacat
     3841 catccctggg gaaaaacact cgggaagaag gagaccacaa aagccagact agagaaagaa
     3901 ttgtatcttg tgtttgttcg ctggaactgt tgcttcctct cctttcctta gtgacctttg
     3961 acctcaccac ccctacttac ttaccttgtt ctgttgggtt tgttgccctc tccctgattc
     4021 tttccacaaa atacatgaat cttgcataag aggttcatgt actagctagg cgtggtggtg
     4081 cacacctgta atcccagcca tgagcagaat gaggcaagaa gacctcaagt tcaaggccag
     4141 catgggctac atagatagtt tctcattaca aacaaaacca aacatcaaga ttcaaaaaat
     4201 gtatgagacg actaggaagg aacatgaggt atcttctact aagagtgcgt gcatgagtgc
     4261 gcgtatgcgt gtgtgtgtgt gtgtatttgc tctactgagt atagaagcta gagcctcccg
     4321 tgtgttaggc aagctttccc tctgagctac agtcccagct ctagcatctc gctgtccttg
     4381 aaaggctggg tggctgccct gggcgggcgg gcttcagcat ggtctgaaca tcacaggcct
     4441 ctgctaatga gatgctcttg gtcatctgcc gcctcgtccc ctgctgggat ctgattggtt
     4501 ctttgcttct gggtgccatg cttcctttgt gacttgtggc caaggatgtg tgctgctgct
     4561 ctcatctgtg ctgagacagc ttggcttttc atcttcgatc acagcttcag tcttggcact
     4621 aggaggacac tttctgcccc tgccctcaga ggccctcctg ggattgtctc actagtctgt
     4681 agtcattcag acttaagctc tagaaataat tcactatttt ctcaaacaca aactccagat
     4741 atcgatttaa aaatggagag cacatttgtc atagttcatg atcacagatt gtcccaacct
     4801 tagccatggg cagcagtgtg tgccttcctg acagtcccat agtcgctctg gcaattgtcc
     4861 cacggtttca gtgctgtgcg gcactgtgac aacttaatac aacatcccca gcactgatat
     4921 tgatgtgggt gggtttgttc catttccttt tactggcaat gtgtgtcagc tcttctgtta
     4981 aataggactt ctcacgtaaa cagttgcttg aatgttgatg tgcctcaaac agctaagttt
     5041 gtcctgattc atccagtaaa ctcacttgtc ttca
//
LOCUS       NM_001438264            1825 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tubulin tyrosine ligase like 2 (Ttll2),
            transcript variant 2, mRNA.
ACCESSION   NM_001438264 XM_008758751
VERSION     NM_001438264.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_008758751.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.452650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000001.1  55524087-55524236   c
            151-253             JAXUCZ010000001.1  55517659-55517761   c
            254-1825            JAXUCZ010000001.1  55515931-55517502   c
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1825
                     /gene="Ttll2"
                     /note="tubulin tyrosine ligase like 2"
                     /db_xref="GeneID:292311"
                     /db_xref="RGD:1305200"
     exon            1..150
                     /gene="Ttll2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..253
                     /gene="Ttll2"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1801
                     /gene="Ttll2"
                     /note="tubulin tyrosine ligase-like family, member 2"
                     /codon_start=1
                     /product="probable tubulin polyglutamylase TTLL2"
                     /protein_id="NP_001425193.1"
                     /db_xref="GeneID:292311"
                     /db_xref="RGD:1305200"
                     /translation="MMNGLQTLGDVTAEIFRLSPEGNTVQKRQRLRMEDEAPGAALKP
                     LVFRVDESTPGVVQSVLLERGWDKFDEQCQDVEDWNLYWRSSSFRMAEYVNIKPWQRL
                     NHHPGTTSLTRKDCLAKHLAHMRRLYGESIYEFTPLTFIMPSDYTKFVAKYFKEKQDL
                     GTKPSYWICKPAKLSQGRGIIIFSDIRDLMFKDAYVVQKYICNPLLVGRYKCDLRIYV
                     CVTGFKPLTIYMYQEGLVRFATEKFDLSNLEDYYSHLTNSSINKLGASYEKIKEVVGQ
                     GCKWTLSRFFSYLRNWDVDDLLLRRKINHMVILTVLAMAPSVPVANNCFELFGFDILI
                     DDNLKPWLLEVNYSPALSLECSTDVSVKRSLVHDIIELLYLNGLRSEEKKCGRTSQGN
                     AMVSQARRSQQKLCAAPAPPSYASLIQFATCSKRSPAAQHMCPKHTRTSQLREMLCRQ
                     NKLLTREAAKSKPRLKAWHSPRKMLSLCASQSLPRKTKGPTGILPEAGNTPNNHAGNF
                     VLIFPFNKATFSASRNGLNVKRIIQELQKLMNK"
     misc_feature    467..1288
                     /gene="Ttll2"
                     /note="Tubulin-tyrosine ligase family; Region: TTL;
                     pfam03133"
                     /db_xref="CDD:397308"
     misc_feature    467..1288
                     /gene="Ttll2"
                     /note="Tubulin-tyrosine ligase family; Region: TTL;
                     pfam03133"
                     /db_xref="CDD:397308"
     exon            254..1825
                     /gene="Ttll2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatccactt agttgcacag tgggcaatac ctactcttgg catctgtatc ccaaagagag
       61 gccattccta gatattaggt tgggggcagg cagatctgca gaagtgacac ccagagacca
      121 gcaccttctg aagaaggccc aggctattca cagtgctgat cacagaggca gggctatgat
      181 gaatggtctg cagactttgg gtgatgtgac tgcagagatt tttagattgt ccccagaggg
      241 aaatactgta cagaaaagac agcgtttgag gatggaggat gaagccccgg gggccgcctt
      301 gaagccgctg gtgttccgag tggacgagag cacacctggg gttgtacaga gtgtcctcct
      361 ggagcgtggg tgggacaaat ttgacgagca atgtcaggat gtggaggact ggaatctgta
      421 ctggagatcg tcctccttcc ggatggcaga gtatgtgaat atcaagccct ggcagaggct
      481 caaccatcac ccagggacaa ccagtctcac caggaaggac tgcctggcca aacacctggc
      541 acacatgagg aggctctacg gtgagtcgat ctatgagttc acacccttga cgttcatcat
      601 gcccagtgac tacaccaagt ttgtggccaa gtacttcaag gagaagcagg acttgggtac
      661 caagccaagc tactggatct gcaagccagc aaagctgtcc caagggaggg ggataatcat
      721 tttcagtgac atccgggacc tcatgttcaa ggacgcgtat gtagtacaga agtacatttg
      781 taaccccttg ctcgtgggta ggtacaagtg cgacctccgc atctatgtct gcgtcactgg
      841 cttcaagcct ttgaccattt acatgtacca ggaagggctg gtgcggtttg ccacggagaa
      901 gtttgacctc agtaatttgg aagattatta ttcccatttg accaacagca gcatcaacaa
      961 attgggggcc tcgtatgaga aaatcaaaga ggtggtgggt caaggctgca agtggaccct
     1021 cagcaggttc ttctcgtacc ttcggaactg ggatgtggac gacctgctgt tgaggcggaa
     1081 gatcaaccac atggtgattc tcactgtcct ggccatggct ccatcagtcc ccgttgccaa
     1141 caactgcttc gagctttttg ggtttgacat cctcattgat gacaacctga agccgtggct
     1201 cttggaagtc aactacagcc ctgctttgag cttggagtgt tccacggacg tctctgtcaa
     1261 gagaagcctc gtccatgata ttattgagct gttatactta aacggcctca ggagtgagga
     1321 gaaaaagtgt gggagaactt ctcagggaaa cgccatggtc tcccaggcca ggagaagtca
     1381 gcaaaagctc tgtgctgccc ctgctccccc ttcttatgcg tctctcatac agtttgcaac
     1441 gtgcagtaaa agaagcccag ctgcccagca catgtgtccc aagcacactc gaacctccca
     1501 gctcagagag atgctgtgca ggcagaacaa acttctgaca agagaggcag ccaaaagcaa
     1561 gccaaggctc aaggcttggc attcgcctcg aaagatgctc tccctatgtg cgtctcagtc
     1621 actgccccgt aagacgaagg gacccacggg catcctcccg gaagctggaa acacaccaaa
     1681 caaccatgcg ggcaactttg ttcttatctt ccctttcaac aaggctactt ttagtgcctc
     1741 cagaaatggg ttaaatgtca aaagaataat tcaagagctc cagaaactaa tgaataaata
     1801 actccaaagt gttaaaaagc caaaa
//
LOCUS       NM_001438319            2984 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 7, mRNA.
ACCESSION   NM_001438319 XM_063284707
VERSION     NM_001438319.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063284707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.973839.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000001.1  144816220-144816332 c
            114-288             JAXUCZ010000001.1  144794240-144794414 c
            289-477             JAXUCZ010000001.1  144734138-144734326 c
            478-701             JAXUCZ010000001.1  144723344-144723567 c
            702-954             JAXUCZ010000001.1  144721538-144721790 c
            955-1068            JAXUCZ010000001.1  144719060-144719173 c
            1069-1205           JAXUCZ010000001.1  144717593-144717729 c
            1206-1404           JAXUCZ010000001.1  144714015-144714213 c
            1405-1499           JAXUCZ010000001.1  144712661-144712755 c
            1500-1580           JAXUCZ010000001.1  144711957-144712037 c
            1581-2984           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2984
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..113
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Cpeb1"
                     /note="upstream in-frame stop codon"
     CDS             99..1679
                     /gene="Cpeb1"
                     /note="isoform 7 is encoded by transcript variant 7; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 7"
                     /protein_id="NP_001425248.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MAFSLEEESGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSL
                     DFSKVCTTPINRGIHDQLPDFQDSEEAITSRMLFPTSAQESPRGLPDANGLCLGLQSL
                     SLTGWDRPWSTQDSDSSAQSNTQSVLSMLQNPLGNVLGKTPLSFLSLDPLGSDLDKFP
                     APSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGN
                     GPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGTSVWPSWDLLGAPKDPFSIER
                     EARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEGYVYLVFELEK
                     SVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDP
                     SRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLK
                     AVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWR
                     HSMEGLRHHSPLMRNQKN"
     misc_feature    99..1016
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    99..1016
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1020..1238
                     /gene="Cpeb1"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1020..1238
                     /gene="Cpeb1"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1269..1520
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1269..1520
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1500..1667
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    1500..1667
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            114..288
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..477
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..701
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..954
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1068
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1205
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1404
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1499
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1580
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2984
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctcgct gcaaaaatag tgcccacgtg tgtgcgcgtc ccgcgccgca cagacccgcc
       61 ggcccgcccg ccagtccctt agggccacgc cggaccccat ggctttttct ctggaagaag
      121 aatcaggaag gataaaggac tgctgggaca accaagaggt tcctgcactc tctacatgta
      181 gcaatgccaa tatctttcga aggataaatg ccattttgga tgattcactg gacttcagta
      241 aagtctgcac aacacctata aatcgaggaa ttcatgatca gttgccagac ttccaggact
      301 ctgaagaagc aattacaagc aggatgcttt tccccacctc tgcgcaagaa tctccccgcg
      361 gcctcccaga tgcaaacggt ttgtgccttg gcctgcagtc actcagtctg actggctggg
      421 accgaccctg gagcacccag gactcagact cctcagccca gagcaacaca cagtcagtat
      481 taagcatgct ccaaaatcca ctgggaaatg tcttaggaaa aacccccttg agcttcctgt
      541 ctctggatcc ccttgggtct gacttggaca agttcccagc gccctcagtt agaggatctc
      601 gcctggacac ccggcctatc ctggactccc gttctagcag cccctctgac tcagacacga
      661 gtggcttcag ctctggatca gatcatctct cagatttgat ttcaagcctt cgcatttccc
      721 ctcctctgcc ctttctttct atgacgggaa atggtcccag agaccctcta aagatgggag
      781 ttgggtctcg aatggaccaa gagcaagctg ctcttgctgc agttgctccc tctccaacca
      841 gtgctccaaa gagatggcca ggaacttctg tgtggccatc ttgggacctt ctcggagctc
      901 ctaaagaccc attcagcata gagagagagg ctagactcca caggcaggcc gcagctgtga
      961 atgaagctac atgtacctgg agtggccagc ttcctccccg gaactacaag aaccccatct
     1021 actcatgcaa ggtgttccta ggaggtgttc cttgggacat tacagaaggg tatgtgtatt
     1081 tggtgtttga actagagaag tccgtccggg ccttgcttca ggcttgttct catgacccac
     1141 tgagcccaga tggcctaagt gaatattatt tcaagatgtc cagccgaagg atgcgctgca
     1201 aagaagtaca ggtaatccct tgggtcttgg ctgacagcaa ctttgtctgg agcccatctc
     1261 agaggctgga tcccagcagg acggtgtttg ttggtgcctt gcacgggatg ctcaatgctg
     1321 aggctctggc tgccatcttg aatgacctat ttggtggagt ggtgtatgct gggattgaca
     1381 cagataagca caagtacccc attgggtctg gtcgtgtgac tttcaataac caacgtagtt
     1441 acctgaaagc agtcactgct gcttttgtgg agatcaaaac caccaagttt accaagaagg
     1501 ttcagatcga cccctatcta gaagattctc tgtgtcttat ctgcagttca caacctggtc
     1561 ctttcttctg ccgagatcag gtctgcttca agtacttttg ccgaagctgc tggcactggc
     1621 gacacagcat ggaaggccta cgccaccaca gcccgctaat gaggaaccag aagaactaaa
     1681 attccagcta gagaagctgg cctggcccag ggcctgtggc gccaaaggct ggcaagtcag
     1741 gcagcagcct gttccctgca cgggcgccta ggagctagct ttctgcagac aagggagaat
     1801 tgtactcacc tttgtacttg ctgagtctgt ctttgtttct gcactaatta atgcacaatg
     1861 agttttgtca ggttttgtct tcagcggggt gtgccagagc aggggcctca ggctcaccct
     1921 caagcaattg tagttttccc agattctagt tcctcatttt gcaaatgaaa acaacaaaaa
     1981 aaactgtgtc tagaacgcgt tgacacagat gcctacactt gggtttattt attaaagcgc
     2041 ttcttacatt ccttgcaata ctgatggtgg tgatgcgcag gtctcattgg tccattcttg
     2101 cagttgccat acagtgcctt tccatttatt taacccccac ctgaacggca taaattgagt
     2161 gttcagctgg tgttttttac tgtaacaaac aaaggagact ttgctcttca tttaaaccaa
     2221 atcatatttc atagtttacg ctcgagggtt tttactggtt cctttttaca ctccttaaaa
     2281 cagtttttaa gtcgtttgga acaatagatt tttttttctt ttttggcagc ttttaacatt
     2341 atagcaaatt tgtgtctggg ggactgctgg tcacagttgc aaatcaaagc atttgtaacc
     2401 aagagaaaaa ttattttatt taaaactgga tgggaggaaa aattaggtct gagcagctgc
     2461 tgtatatagt tttaaatggt ttgtcgcacc ttatgttgca cttacgttgg gggagggttg
     2521 atagaagttt ttaatcacag tcacaggact ttttcttttg taactgagct taaaaattaa
     2581 aaaaaaaaaa agggctgctt tttggtgggg gcggatgaag gctcacagga gccctttctc
     2641 ttagaggggc aagtaccctt ccttacaact tttatttgaa gaatgtatga atcaacagtt
     2701 attgttgaca aaaatgttac tggaattgaa aacttgactc tttttttaaa aatttagtta
     2761 ctacttgccc ctcttaggga agctgtgtgc caaagaacca gtgtcgcccc cctgctgagc
     2821 tgacgttgca ttgtcgcata tcccagctac tctgtgggct cgtgaagctg tgtgtgaagt
     2881 ctctacctca ttgttgtaca tgcaggcaag actgcactct gtacagattg tggagtaagc
     2941 tgtggtgtac tttttttggc acataataaa cacgttgcag caga
//
LOCUS       NM_001438256            3113 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 7, mRNA.
ACCESSION   NM_001438256
VERSION     NM_001438256.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.494.1, SRR26643290.406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-368             JAXUCZ010000001.1  36697967-36698120
            369-486             JAXUCZ010000001.1  36699898-36700015
            487-555             JAXUCZ010000001.1  36702543-36702611
            556-681             JAXUCZ010000001.1  36703970-36704095
            682-835             JAXUCZ010000001.1  36705450-36705603
            836-924             JAXUCZ010000001.1  36706668-36706756
            925-1105            JAXUCZ010000001.1  36707831-36708011
            1106-1148           JAXUCZ010000001.1  36709666-36709708
            1149-1335           JAXUCZ010000001.1  36722626-36722812
            1336-1454           JAXUCZ010000001.1  36723647-36723765
            1455-1547           JAXUCZ010000001.1  36724215-36724307
            1548-1733           JAXUCZ010000001.1  36724407-36724592
            1734-3113           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3113
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            215..368
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            369..486
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    475..477
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     exon            487..555
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            556..681
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            682..835
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             817..1878
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 5 is encoded by transcript variant 7;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 5"
                     /protein_id="NP_001425185.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSD
                     YTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKL
                     QPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTE
                     VLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQE
                     QHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAP
                     AKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEA
                     MKTLATLKQEKRYLQDIWS"
     misc_feature    820..1872
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    820..1872
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1129..1140,1183..1188,1237..1248,1351..1353,
                     1870..1872)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1129..1140,1183..1188,1237..1248,1351..1353,
                     1870..1872)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1129..1131,1135..1140)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1129..1131,1135..1140)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1138..1140,1729..1731,1864..1866,1870..1872)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1138..1140,1729..1731,1864..1866,1870..1872)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1189..1200,1411..1413,1417..1419,1516..1521,
                     1606..1611,1651..1653,1657..1659,1747..1749)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1189..1200,1411..1413,1417..1419,1516..1521,
                     1606..1611,1651..1653,1657..1659,1747..1749)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1237..1239,1246..1248,1255..1257)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1237..1239,1246..1248,1255..1257)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1402..1404,1414..1425,1429..1431)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1402..1404,1414..1425,1429..1431)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            836..924
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1105
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1148
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1335
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1454
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1547
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1733
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..3113
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtatgat ctgaaaaccg aaactggccc
      241 tctggtgatg gttgtatcta ccacgggtac tggagaccca cccgacacag cccgcaagtt
      301 tgtgaaagaa atacacaaca agacactacc cacagacttc tttgctcacc tgtggtatgg
      361 attattgggt ttgggtgact cagaatacac atacttctgc aatggaggga aagtaattga
      421 taaacgactt caggagcttg gagcccagca tttctatgac actggacatg ccgatgactg
      481 cgtaggagct ctctaagtat tcctgctgtg tccccagaat atttggaggt ctatcttcag
      541 gagtctcttg gccaggatga aaaccaagca tctgtgccac catcagtcga tccaattttt
      601 caagttccaa tttcaaaagc tgttgagctg actacaaacg atgccataaa gaccactctg
      661 ctgttggaat tggacatctc aaaagtagag ttttcccatc aacctggaga ttccttcaat
      721 gtgatctgtc caaacagtgg ttctgaagta gaagacttgc tgcaaaggct gcagctggct
      781 gacaaacaag cacaccgggt catcctgaaa attaagatgg acaccaagaa gaaaggagct
      841 tctctgcccc agcatgtgcc tgaggggagt tctctccagt tcatcttcac ctggtgtctt
      901 gaaatacgag cagttcctaa aaaggctttt ttgagggccc tttcggatta caccagcgat
      961 gccactgaaa agcggaggct tcaggagctc tgcagtaagc agggagcagc tgattacaac
     1021 cgcttcatcc gagatgccag tgtctgcctg ctagacctcc tgcttacctt cccatcctgc
     1081 cagcctccgc tcaacctcct gctggagcac cttcctaaac tccagcctcg accatactcg
     1141 tgcgcaagct ccagcttact ccatccagac aagcttcact ttgtgtttaa catcgtagag
     1201 cttccgtcga acaccactgc agcctcactg cggaagggag tgtgcacagg ctggctagcc
     1261 acattggttg ctccatttct tcagccaaac acagaagttt tgactgcaga ccatagtgat
     1321 gctctggctc ctgagatact tatctctcct cgggcaacaa attccttcca cttaccagat
     1381 gacctgtcgg cccccatcat aatggtgggt ccaggaactg gtgtagcccc ctttgttggc
     1441 ttcctgcagc acagagaaaa actccaagaa caacacccag acggaaactt tggagcaatg
     1501 tggctgtttt ttggctgcag acataaggac agagactatt tgttcaggga ggagctcagg
     1561 catttcctca agactggggt cttgactcac ctgaaggtct cattctcaag agatgctgcg
     1621 cctgaggaag aggaggaggc cccagcaaag tatgtgcaag acaacctcca gcatcacagc
     1681 cagcaggtgg ccaggaccct ccttcaggag aatggctaca tttacgtgtg tggagacgcc
     1741 aagaatatgg ctaaggatgt acacgacgcc cttgtagaaa tcataagcaa agaagctgga
     1801 gttgacaaac tagaagcaat gaagacactg gcaaccttaa agcaagaaaa gcggtatctg
     1861 caggatatct ggtcgtgaaa ctagaaggga ggtttcagtg tgcttgcttg cttgtttgtt
     1921 ttttgaaatg ccaaaggaca gttgtacaga agataggttt tgggtatttc ttggcagagg
     1981 ctttgtgggg aacagctcac ttacaggtac caccgcctga tacaatctca ggtttgtctc
     2041 ccactctgtg tcccacccag caccccactg tgtggagcgg agaggcagct ctcagctggc
     2101 tcccaaggag gacagatagt cgtcaatggc tctgggcaca tcgtggagag tttgtggaca
     2161 tgttctcttt caatgaagta cattcagagg atattcattc tgatgatatt taaattaata
     2221 cagacataca gagcatactt ttgcatgttt gcacttaatt gtggtttatt atcaaaatta
     2281 tatttctgat aaaatatttt aattttgagg taatccttac aaaataaggg tttttatgct
     2341 actagaaata tattttgaaa tacaattgaa attgtgctct gccattttca tcatgttaac
     2401 ttttagtgtc acagtcctac agcttagggg catttgcatt cccctgacaa aggcatgtgt
     2461 gtacatctca gtaacatcat gccctgttct cctggactct attcatcaat gctcctcact
     2521 aacagacttg gtattcccca atacctgact gtacttctgt gattcagctc agagtaaaga
     2581 gctccagtta gacttctaat accaaattct cttgcaagtt tcgaaaataa agcatataaa
     2641 aggattctgt gccattgtgt gtatggttgc tgagacaaaa ctgggacaaa gcaacttaat
     2701 gagagatggt atttctgctc acagttccag tatgtggtcc atggtgctgg tgaagtcatg
     2761 gtggcagaag gagaagacaa ctggtcatgt tacatccagt cagaaggaaa cgacatgcat
     2821 gcctcactgg ctttctcctt ttcacacaca ctgtctagaa ctttcacaca cagaatgggt
     2881 ctgcctacat gtactgtggg tgttcacctc agcgtagtcc agaggacctc tcagcagtgg
     2941 tttgtctcca gtgaggccac agccatcaca tgcatgataa actctccatt cagtgtatag
     3001 ttattgtctt gtttaatagt tcaacattta aaacacaact ctgcctggtg agatgtcact
     3061 aagagactcc ctggtcatta taagaattaa agatttgaaa aaataatctc aaa
//
LOCUS       NM_001438260            4841 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 5, mRNA.
ACCESSION   NM_001438260 XM_063282791
VERSION     NM_001438260.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4841)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 4841)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 4841)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 4841)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 4841)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 4841)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 4841)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 4841)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282791.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1978067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  265880949-265881004
            57-119              JAXUCZ010000001.1  265883848-265883910
            120-452             JAXUCZ010000001.1  265885603-265885935
            453-508             JAXUCZ010000001.1  265888925-265888980
            509-653             JAXUCZ010000001.1  265892382-265892526
            654-759             JAXUCZ010000001.1  265893680-265893785
            760-823             JAXUCZ010000001.1  265896331-265896394
            824-928             JAXUCZ010000001.1  265897265-265897369
            929-1111            JAXUCZ010000001.1  265897587-265897769
            1112-1255           JAXUCZ010000001.1  265898203-265898346
            1256-1427           JAXUCZ010000001.1  265898771-265898942
            1428-1514           JAXUCZ010000001.1  265899871-265899957
            1515-1682           JAXUCZ010000001.1  265902762-265902929
            1683-1790           JAXUCZ010000001.1  265903044-265903151
            1791-1961           JAXUCZ010000001.1  265903930-265904100
            1962-2204           JAXUCZ010000001.1  265905270-265905512
            2205-2342           JAXUCZ010000001.1  265905824-265905961
            2343-2453           JAXUCZ010000001.1  265908907-265909017
            2454-2624           JAXUCZ010000001.1  265909555-265909725
            2625-2897           JAXUCZ010000001.1  265912578-265912850
            2898-3017           JAXUCZ010000001.1  265914596-265914715
            3018-3134           JAXUCZ010000001.1  265915981-265916097
            3135-3233           JAXUCZ010000001.1  265918742-265918840
            3234-3461           JAXUCZ010000001.1  265920045-265920272
            3462-3508           JAXUCZ010000001.1  265920791-265920837
            3509-3601           JAXUCZ010000001.1  265920914-265921006
            3602-4841           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..4841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4841
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..56
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..119
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..452
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             149..3601
                     /gene="Tdrd1"
                     /note="isoform 2 is encoded by transcript variant 5; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 2"
                     /protein_id="NP_001425189.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGL
                     TELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNVHAVSVEKCSENGMINIAENLVMC
                     GLAENLSSKRESASTKETPHSTDCCCTELQKQIEKHEQILLFLLNNPTNQNKFIEMKK
                     LLQS"
     misc_feature    632..742
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    632..742
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    929..1318
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    929..1318
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1097..1099,1118..1120,1172..1174,1181..1183,
                     1187..1189)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1097..1099,1118..1120,1172..1174,1181..1183,
                     1187..1189)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1679..1924
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1679..1924
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1784..1786,1805..1807,1856..1858,1865..1867,
                     1871..1873)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1784..1786,1805..1807,1856..1858,1865..1867,
                     1871..1873)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2270..2620
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2270..2620
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2957..3235
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    2957..3235
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     exon            453..508
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..653
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..759
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..823
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..928
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1111
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1255
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1427
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1514
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1682
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1790
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1961
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2204
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2342
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2453
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2624
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2897
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3017
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3134
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3233
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3461
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3508
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3601
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..4841
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcgca ggcgcgggat caacagcacg cggcagcctt gagcgtccga ggcgaggtga
       61 aggcagcact ggatgtctga gcgtttgcag gtcaacacat gagtaagagt tgcaaaaaga
      121 cgtcagtgaa tgttaagtta catctaatat gatgccacga aataatttgg aagcctctac
      181 ttgtaaaatg gcagaaccat ttaattttga gaaaaaggaa agcaaacttc caccccacga
      241 ttctctaaga agtcctgtac cacagcataa ccatcccaat ttcagactga aaagcccaga
      301 gaacggaaat aaaaagaaca attttttgct ttgtgaacaa aacaaacagt acttggctag
      361 tcaggaagac aattcggtgg tctcttcaaa ccctgctggt atcaatggag aagtaggtgg
      421 gtccaaagga gacaggaaga cattaccaac aggaaaccca gtatcattaa gtcttggaaa
      481 caattcacca cctaaccaag taaaaactaa gcccagcaat gctgtgactc ctgaaaaatc
      541 aaaaaaatct cacaagctgt ttgagaatgc cttgtccgta aataacccag ctctcttcaa
      601 ctcgttagga ccgcccctgc ggtccacaac ctgccatcgc tgtggcctgt tcgggtcgct
      661 gaggtgttcc cagtgcaagc agacatatta ctgctccaca gcatgccaga ggagagactg
      721 gtcttcccat agcaccatct gtagacctgt gcagcaaagt ctgcataagc ttgaagataa
      781 taagtcacca tttgaaacaa agaccattga cgtgaagaat gaggttgcct gtcccctggg
      841 agttactaaa gaaatgacag ctggtgcaga gagagtaatg ttttctgatc tgaggagtct
      901 ccaactgagg aaatccatgg aaataaaggg cacagttact gaattcaagc acccgggtca
      961 tttttatgtc cagttgtatt cctcagaggt tttagagtac atgaaccaac tctctgcaag
     1021 tttgaaagag acatatgcaa atatggtgcc tgaagacgga tatcttcctg ttaaggggga
     1081 agtctgtgtt gccaagtaca cggttgatca gacctggaac cgagccgtag tagaaggcgt
     1141 ggacgtgctg cagaagaagg cacatgtctt gtacatcgac tacggaaatg aagagatcat
     1201 cccagtcgac agaatccacc agctaagcag aagtatcagc ctgtttcccc cttccgccat
     1261 aaagtgctat gtgtcaggag tcgtccccgc tgcgggtgag tggactgaag actgtgttgt
     1321 agctgtcaag gctctgctgt tcgagcagta ctgctctatc aaggtcgtgg acatctcaga
     1381 ggaggagggg ctcacctgtg ctgtcgacgt cgtgctgcag agttcaggaa aacagctgga
     1441 ccatgtgctt gtggaaatgg gatatggtgt gaaacctgat gagccgagct ccaagaagca
     1501 aagtatggac ccaggcactt cggaggacac tggaagactg acagctgaga acaggatcgg
     1561 ggcagagaga aatgccctgg tccccacagt gctgactttg aatgtgggtg acgagttctg
     1621 tggtgtagtt gcccacatcc agacaccaga ggacttcttt tgtcagcagc tgcagagtgg
     1681 ccacaagctc gccgagcttc aggagtccct cagtgagtac tgtagccacg tgactccacg
     1741 ctcagacttt tatccaacca ttggggacat gtgttgtgct cagttctcag aggatgacca
     1801 atggtaccgc gcctcggttc tggcctatgc ttcagaagaa tctgtcctgg ttggatatgt
     1861 cgattatgga aactttgaaa ttcttagttt gaaaagactt tgtcccataa ttccaaagtt
     1921 gttggatttg ccgatgcaag ctttaaattg tgtgctggca ggagtgaagc catctttagg
     1981 aatgtggact ccagaagcca tttgtgtcat gaggaaggct gtgcagaaca ggatggtgac
     2041 cgtgagagtg gtgggcatgc aggggaccag ggccctggtg gagctcgtag acaaatcggt
     2101 ggctcctcac ctcagcgctt ctaaagctct gctagactcc ggctttgcca tcgaggaaaa
     2161 ggacatagtg gcagataaag gcagcagtgc gcgtgcctcg aatgttccct tggctgtaga
     2221 aggagcagtg gaggtgctgg agtggacgtg ggtcgagttc accgttgacg agactgtgga
     2281 cgtgatggtc tgcatgatgc acagccctgg ggagttctac tgccactgtc tcaaagacga
     2341 cgccttaaag aagctcgatg acttgaacaa gtccttagca gactactgtg cacaaaaacc
     2401 gcccaatggc ttcaaggcag aggtagggcg gccttgctgt gcctgttttg caggtgacgg
     2461 caactggtac cgggctctgg tcaaggagat cctaccaagt gggaacgtca aagtacactt
     2521 tgtggactac ggcaatgttg aagaggttac cacagaccaa ctgcacgcaa tagcccccca
     2581 gttcttacta cttccgttcc aagggatgca gtgctggcta gtagatatac agcccaaaaa
     2641 caagcattgg acaaaagaag ccacagcaag atttcaagca tgtgtcgtgg ggcttaaact
     2701 tcaagccaga gttgtggaaa tcacggagaa tggggtgggc gttgaactca ccgatctttc
     2761 caccccctac cccaaaatca ttagtgacgt tctcatcaca gaacatctgg tcttaaggtg
     2821 tggttcacca cagaaggacg agttgatgag cagacctgct aataaacata accagatcga
     2881 ctcccagagc gtgcaagcca gccctcctgc agagcagtgg aagaccatag agttgccagt
     2941 taacaagact gtaccagcaa atgtactaga aatcataagc ccaaccttgt tttatgccat
     3001 ccccagtgaa atgccagaaa atcaagaaaa actgtgtgtg ttgacagctg aattgttaga
     3061 acactgtaac gctcagaaag gccagccacc ctacagacca cggacgggag aagcctgctg
     3121 tgctaaatac acaaattatg gaaacgtgga aagactgcct ttttccagag tgcagcccat
     3181 cactgccagc cacctgcagc tgcccttccg catcattaga tgctcacttg aggggctgac
     3241 ggagctgaac ggaagcagtt cgcagccagt gatggagctg ctgaggaacg ccatgctgaa
     3301 ccagagtgtg gctctctctg tgaaagcagt ctcgaagaat gtccatgcag tgtcagttga
     3361 aaaatgttct gaaaatggaa tgatcaatat agctgagaat ctggtgatgt gtggcctggc
     3421 agaaaacctc tcatctaaaa gggaaagtgc ttcaactaaa gaaacaccgc acagcaccga
     3481 ttgctgctgc acagagttac agaaacagat tgagaaacac gaacagattc tcctcttcct
     3541 cttaaacaat ccaaccaacc aaaataaatt tatagagatg aaaaagctgc tgcaaagcta
     3601 aaaacatcat ccctggggaa aaacactcgg gaagaaggag accacaaaag ccagactaga
     3661 gaaagaattg tatcttgtgt ttgttcgctg gaactgttgc ttcctctcct ttccttagtg
     3721 acctttgacc tcaccacccc tacttactta ccttgttctg ttgggtttgt tgccctctcc
     3781 ctgattcttt ccacaaaata catgaatctt gcataagagg ttcatgtact agctaggcgt
     3841 ggtggtgcac acctgtaatc ccagccatga gcagaatgag gcaagaagac ctcaagttca
     3901 aggccagcat gggctacata gatagtttct cattacaaac aaaaccaaac atcaagattc
     3961 aaaaaatgta tgagacgact aggaaggaac atgaggtatc ttctactaag agtgcgtgca
     4021 tgagtgcgcg tatgcgtgtg tgtgtgtgtg tatttgctct actgagtata gaagctagag
     4081 cctcccgtgt gttaggcaag ctttccctct gagctacagt cccagctcta gcatctcgct
     4141 gtccttgaaa ggctgggtgg ctgccctggg cgggcgggct tcagcatggt ctgaacatca
     4201 caggcctctg ctaatgagat gctcttggtc atctgccgcc tcgtcccctg ctgggatctg
     4261 attggttctt tgcttctggg tgccatgctt cctttgtgac ttgtggccaa ggatgtgtgc
     4321 tgctgctctc atctgtgctg agacagcttg gcttttcatc ttcgatcaca gcttcagtct
     4381 tggcactagg aggacacttt ctgcccctgc cctcagaggc cctcctggga ttgtctcact
     4441 agtctgtagt cattcagact taagctctag aaataattca ctattttctc aaacacaaac
     4501 tccagatatc gatttaaaaa tggagagcac atttgtcata gttcatgatc acagattgtc
     4561 ccaaccttag ccatgggcag cagtgtgtgc cttcctgaca gtcccatagt cgctctggca
     4621 attgtcccac ggtttcagtg ctgtgcggca ctgtgacaac ttaatacaac atccccagca
     4681 ctgatattga tgtgggtggg tttgttccat ttccttttac tggcaatgtg tgtcagctct
     4741 tctgttaaat aggacttctc acgtaaacag ttgcttgaat gttgatgtgc ctcaaacagc
     4801 taagtttgtc ctgattcatc cagtaaactc acttgtcttc a
//
LOCUS       NM_001438320            3164 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 8, mRNA.
ACCESSION   NM_001438320
VERSION     NM_001438320.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.276718.1,
                                           SRR26360176.1873699.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000001.1  144816458-144816660 c
            204-378             JAXUCZ010000001.1  144794240-144794414 c
            379-567             JAXUCZ010000001.1  144734138-144734326 c
            568-791             JAXUCZ010000001.1  144723344-144723567 c
            792-1044            JAXUCZ010000001.1  144721538-144721790 c
            1045-1158           JAXUCZ010000001.1  144719060-144719173 c
            1159-1248           JAXUCZ010000001.1  144718672-144718761 c
            1249-1385           JAXUCZ010000001.1  144717593-144717729 c
            1386-1584           JAXUCZ010000001.1  144714015-144714213 c
            1585-1679           JAXUCZ010000001.1  144712661-144712755 c
            1680-1760           JAXUCZ010000001.1  144711957-144712037 c
            1761-3164           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3164
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..203
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Cpeb1"
                     /note="upstream in-frame stop codon"
     exon            204..378
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..567
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1859
                     /gene="Cpeb1"
                     /note="isoform 8 is encoded by transcript variant 8; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 8"
                     /protein_id="NP_001425249.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSS
                     AQSNTQSVLSMLQNPLGNVLGKTPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDS
                     RSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQE
                     QAALAAVAPSPTSAPKRWPGTSVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCT
                     WSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCP
                     PKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLAD
                     SNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGS
                     GRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQV
                     CFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN"
     misc_feature    <414..1106
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    <414..1106
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1110..1418
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1110..1418
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1449..1700
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1449..1700
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1680..1847
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    1680..1847
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            568..791
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1044
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1158
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1248
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1385
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1584
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1679
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1760
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..3164
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgcagctg cagcgcaggg tcttgtaaat ctgtagggaa actgaggcct gcgggagagt
       61 gacttggcca gggtcactag gcgaggggtg tgctcaggcc tgaacccttg gactcccgga
      121 ggcagcggtg gcctgcatcg gttcgagctt cagaactagc cccggttcgg acccccaggc
      181 ccagggtggg cggtggagcg ccggaagaag aatcaggaag gataaaggac tgctgggaca
      241 accaagaggt tcctgcactc tctacatgta gcaatgccaa tatctttcga aggataaatg
      301 ccattttgga tgattcactg gacttcagta aagtctgcac aacacctata aatcgaggaa
      361 ttcatgatca gttgccagac ttccaggact ctgaagaagc aattacaagc aggatgcttt
      421 tccccacctc tgcgcaagaa tctccccgcg gcctcccaga tgcaaacggt ttgtgccttg
      481 gcctgcagtc actcagtctg actggctggg accgaccctg gagcacccag gactcagact
      541 cctcagccca gagcaacaca cagtcagtat taagcatgct ccaaaatcca ctgggaaatg
      601 tcttaggaaa aacccccttg agcttcctgt ctctggatcc ccttgggtct gacttggaca
      661 agttcccagc gccctcagtt agaggatctc gcctggacac ccggcctatc ctggactccc
      721 gttctagcag cccctctgac tcagacacga gtggcttcag ctctggatca gatcatctct
      781 cagatttgat ttcaagcctt cgcatttccc ctcctctgcc ctttctttct atgacgggaa
      841 atggtcccag agaccctcta aagatgggag ttgggtctcg aatggaccaa gagcaagctg
      901 ctcttgctgc agttgctccc tctccaacca gtgctccaaa gagatggcca ggaacttctg
      961 tgtggccatc ttgggacctt ctcggagctc ctaaagaccc attcagcata gagagagagg
     1021 ctagactcca caggcaggcc gcagctgtga atgaagctac atgtacctgg agtggccagc
     1081 ttcctccccg gaactacaag aaccccatct actcatgcaa ggtgttccta ggaggtgttc
     1141 cttgggacat tacagaagct ggattggtta acaccttccg tgtttttggc tctctgagtg
     1201 tggagtggcc tggtaaggat ggcaagcacc cccggtgtcc tcccaaaggg tatgtgtatt
     1261 tggtgtttga actagagaag tccgtccggg ccttgcttca ggcttgttct catgacccac
     1321 tgagcccaga tggcctaagt gaatattatt tcaagatgtc cagccgaagg atgcgctgca
     1381 aagaagtaca ggtaatccct tgggtcttgg ctgacagcaa ctttgtctgg agcccatctc
     1441 agaggctgga tcccagcagg acggtgtttg ttggtgcctt gcacgggatg ctcaatgctg
     1501 aggctctggc tgccatcttg aatgacctat ttggtggagt ggtgtatgct gggattgaca
     1561 cagataagca caagtacccc attgggtctg gtcgtgtgac tttcaataac caacgtagtt
     1621 acctgaaagc agtcactgct gcttttgtgg agatcaaaac caccaagttt accaagaagg
     1681 ttcagatcga cccctatcta gaagattctc tgtgtcttat ctgcagttca caacctggtc
     1741 ctttcttctg ccgagatcag gtctgcttca agtacttttg ccgaagctgc tggcactggc
     1801 gacacagcat ggaaggccta cgccaccaca gcccgctaat gaggaaccag aagaactaaa
     1861 attccagcta gagaagctgg cctggcccag ggcctgtggc gccaaaggct ggcaagtcag
     1921 gcagcagcct gttccctgca cgggcgccta ggagctagct ttctgcagac aagggagaat
     1981 tgtactcacc tttgtacttg ctgagtctgt ctttgtttct gcactaatta atgcacaatg
     2041 agttttgtca ggttttgtct tcagcggggt gtgccagagc aggggcctca ggctcaccct
     2101 caagcaattg tagttttccc agattctagt tcctcatttt gcaaatgaaa acaacaaaaa
     2161 aaactgtgtc tagaacgcgt tgacacagat gcctacactt gggtttattt attaaagcgc
     2221 ttcttacatt ccttgcaata ctgatggtgg tgatgcgcag gtctcattgg tccattcttg
     2281 cagttgccat acagtgcctt tccatttatt taacccccac ctgaacggca taaattgagt
     2341 gttcagctgg tgttttttac tgtaacaaac aaaggagact ttgctcttca tttaaaccaa
     2401 atcatatttc atagtttacg ctcgagggtt tttactggtt cctttttaca ctccttaaaa
     2461 cagtttttaa gtcgtttgga acaatagatt tttttttctt ttttggcagc ttttaacatt
     2521 atagcaaatt tgtgtctggg ggactgctgg tcacagttgc aaatcaaagc atttgtaacc
     2581 aagagaaaaa ttattttatt taaaactgga tgggaggaaa aattaggtct gagcagctgc
     2641 tgtatatagt tttaaatggt ttgtcgcacc ttatgttgca cttacgttgg gggagggttg
     2701 atagaagttt ttaatcacag tcacaggact ttttcttttg taactgagct taaaaattaa
     2761 aaaaaaaaaa agggctgctt tttggtgggg gcggatgaag gctcacagga gccctttctc
     2821 ttagaggggc aagtaccctt ccttacaact tttatttgaa gaatgtatga atcaacagtt
     2881 attgttgaca aaaatgttac tggaattgaa aacttgactc tttttttaaa aatttagtta
     2941 ctacttgccc ctcttaggga agctgtgtgc caaagaacca gtgtcgcccc cctgctgagc
     3001 tgacgttgca ttgtcgcata tcccagctac tctgtgggct cgtgaagctg tgtgtgaagt
     3061 ctctacctca ttgttgtaca tgcaggcaag actgcactct gtacagattg tggagtaagc
     3121 tgtggtgtac tttttttggc acataataaa cacgttgcag caga
//
LOCUS       NM_001008303            1261 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide A
            (Snrpa), transcript variant 1, mRNA.
ACCESSION   NM_001008303 XM_214845
VERSION     NM_001008303.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Kondo,Y., Oubridge,C., van Roon,A.M. and Nagai,K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Bai,B., Hales,C.M., Chen,P.C., Gozal,Y., Dammer,E.B., Fritz,J.J.,
            Wang,X., Xia,Q., Duong,D.M., Street,C., Cantero,G., Cheng,D.,
            Jones,D.R., Wu,Z., Li,Y., Diner,I., Heilman,C.J., Rees,H.D., Wu,H.,
            Lin,L., Szulwach,K.E., Gearing,M., Mufson,E.J., Bennett,D.A.,
            Montine,T.J., Seyfried,N.T., Wingo,T.S., Sun,Y.E., Jin,P.,
            Hanfelt,J., Willcock,D.M., Levey,A., Lah,J.J. and Peng,J.
  TITLE     U1 small nuclear ribonucleoprotein complex and RNA splicing
            alterations in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16562-16567 (2013)
   PUBMED   24023061
REFERENCE   4  (bases 1 to 1261)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   5  (bases 1 to 1261)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 1261)
  AUTHORS   Novakova,Z., Man,P., Novak,P., Hozak,P. and Hodny,Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   7  (bases 1 to 1261)
  AUTHORS   Sinha,K., Perumal,K., Chen,Y. and Reddy,R.
  TITLE     Post-transcriptional adenylation of signal recognition particle RNA
            is carried out by an enzyme different from mRNA Poly(A) polymerase
  JOURNAL   J Biol Chem 274 (43), 30826-30831 (1999)
   PUBMED   10521474
REFERENCE   8  (bases 1 to 1261)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1261)
  AUTHORS   Nagai,K., Oubridge,C., Jessen,T.H., Li,J. and Evans,P.R.
  TITLE     Crystal structure of the RNA-binding domain of the U1 small nuclear
            ribonucleoprotein A
  JOURNAL   Nature 348 (6301), 515-520 (1990)
   PUBMED   2147232
REFERENCE   10 (bases 1 to 1261)
  AUTHORS   Craft,J., Mimori,T., Olsen,T.L. and Hardin,J.A.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001008303.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086331.1, SRR22399484.1559719.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000001.1  91617980-91618157   c
            179-273             JAXUCZ010000001.1  91617449-91617543   c
            274-446             JAXUCZ010000001.1  91615046-91615218   c
            447-623             JAXUCZ010000001.1  91613872-91614048   c
            624-797             JAXUCZ010000001.1  91611727-91611900   c
            798-886             JAXUCZ010000001.1  91611264-91611352   c
            887-1261            JAXUCZ010000001.1  91609419-91609793   c
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1261
                     /gene="Snrpa"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
     exon            1..178
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            179..273
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Snrpa"
                     /note="upstream in-frame stop codon"
     CDS             201..1046
                     /gene="Snrpa"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_001008304.1"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
                     /translation="MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIL
                     VSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFV
                     ERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMTQAPRIMHHMPGQP
                     PYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEET
                     NELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKI
                     SFAKK"
     misc_feature    219..485
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    219..485
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    <234..>821
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    <234..>821
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    order(237..239,243..248,255..257,330..332,336..338,
                     342..362,366..368,438..440,447..449,453..476)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    order(237..239,243..248,255..257,330..332,336..338,
                     342..362,366..368,438..440,447..449,453..476)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    786..1043
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     misc_feature    786..1043
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     exon            274..446
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            447..623
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            624..797
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            798..886
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1261
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgttctt ttcctgggca ggcactgagg cccgggaaga gacttattct gaacttacgg
       61 agtttgcggg ccctgattag ctcgcggaag ggggtagccg gaaccaggga agaaagaagc
      121 tgtgtgtctt tgcagcgtag cttggcgggc gctgtcggtc tgagcgacgg cttaggtgca
      181 gtacctgaac atctcacacc atggcagttc ccgagacccg tcccaaccac actatttata
      241 tcaacaatct caatgagaag atcaagaaag atgagctcaa gaagtccctg tatgccatct
      301 tctcccagtt tggccagatc ctggatatcc tggtgtctcg gagcctgaag atgaggggcc
      361 aggccttcgt catcttcaag gaggtcagca gtgccaccaa cgccctgcgt tccatgcagg
      421 gcttcccttt ctacgacaag cccatgcgta tccagtacgc aaagactgac tcagacatca
      481 ttgccaaaat gaagggcacc tttgtggaga gagatcgcaa acgtgagaag aggaagccca
      541 agagtcagga gacacctgct gccaaaaagg ctgttcaggg tggggcagct gcccctgtgg
      601 ttggcgctgt ccagcctgta ccgggcatgc caccgatgac tcaggcaccc cgcatcatgc
      661 accacatgcc aggacagcct ccctacatgc caccacctgg catgatcccg ccaccaggcc
      721 ttgctcctgg ccagatccct cctggggcaa tgcccccaca gcagctcatg cctgggcaga
      781 tgccacctgc ccaacctctc tcggagaatc cacccaatca catcctgttc ctcaccaacc
      841 tgcctgagga gaccaacgag ctcatgctct ccatgctctt caaccagttc cctggcttca
      901 aggaggtgcg tctggtccct gggcgccatg acattgcctt cgtggagttt gacaatgaag
      961 tgcaggctgg ggcagcacga gatgccctgc aaggcttcaa gatcacacag aacaatgcaa
     1021 tgaagatctc ttttgccaag aagtagcacc tttccctacg gagtgcccca gtccccattc
     1081 tggggctgcc ccttccccct ctcttggctc agtccctgaa ggtaagtccc ccttgggggc
     1141 cttctcagag ccgtgagtga gtgtgtgtct gccacacagc attgtaccca gggtcttccc
     1201 agacattgca cctggcgctg ttgggttgtg attaaagtga gtttttaggt ttggtttttc
     1261 a
//
LOCUS       NM_001438300             638 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12),
            transcript variant 4, mRNA.
ACCESSION   NM_001438300
VERSION     NM_001438300.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 638)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 638)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 638)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2312969.1,
                                           SRR26360176.412975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                JAXUCZ010000001.1  93156288-93156306   c
            20-638              JAXUCZ010000001.1  93153424-93154042   c
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..638
                     /gene="Mrps12"
                     /note="mitochondrial ribosomal protein S12"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
     exon            1..19
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    13..15
                     /gene="Mrps12"
                     /note="upstream in-frame stop codon"
     exon            20..638
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..390
                     /gene="Mrps12"
                     /note="isoform 2 is encoded by transcript variant 4; 28S
                     ribosomal protein S12, mitochondrial; small ribosomal
                     subunit protein uS12m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12m isoform 2"
                     /protein_id="NP_001425229.1"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
                     /translation="MATLNQMHRLGRPKEPPKRLGPTEGRPQLKGVVLRTFIRKPKKP
                     NSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLVEGGRTQDLPGVKLKVVRGKYD
                     CGHVQKKK"
     misc_feature    64..384
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    64..384
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    order(67..72,76..81,88..93)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    order(67..72,76..81,88..93)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    67..69
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    67..69
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    order(91..99,130..132,136..141,145..147,190..195,199..207,
                     226..228,250..252,259..264,301..306,316..321,382..384)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(91..99,130..132,136..141,145..147,190..195,199..207,
                     226..228,250..252,259..264,301..306,316..321,382..384)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(181..186,316..318)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(181..186,316..318)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    184..189
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    184..189
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(187..204,262..288)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     misc_feature    order(187..204,262..288)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
ORIGIN      
        1 gtacgaccct gctagtttgg cctagcccta gctccccagc tctgggccac ccgttccatg
       61 gccaccctga accagatgca ccgcttaggc cgcccgaagg aaccccctaa gcgtctgggc
      121 cccacggagg gccggcccca gctgaagggt gtggtgttgc gcacatttat caggaagccg
      181 aagaagccca actccgccaa ccggaagtgc tgccgagtac gcctcagcac cggcaaagag
      241 gctgtctgct tcatccccgg cgagggccac accctgcagg agcaccacgt ggtcctcgtg
      301 gagggtggtc gcacccagga cctgcctggg gttaaactca aagttgtgag gggcaagtat
      361 gactgcggcc acgtgcagaa gaagaaatga ccataattca cagtgatctg ctactggatc
      421 cttggaaacg ggttctttct gctccagggg cagcttttct tgggttcaaa tcttactctg
      481 actcagcaag atgctattaa cctgcaagat ttctgaaggt gaattggaag gaggaactct
      541 tgtgcccact cccttgactt ccatgttcag tgtctgcagg ttgacctcat gcgctgggat
      601 gggggttgta ataaacatat cttcaggttg tgatgtca
//
LOCUS       NM_001438261            4778 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 6, mRNA.
ACCESSION   NM_001438261 XM_063282792
VERSION     NM_001438261.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4778)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 4778)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 4778)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 4778)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 4778)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 4778)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 4778)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 4778)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282792.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.9497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  265880949-265881004
            57-389              JAXUCZ010000001.1  265885603-265885935
            390-445             JAXUCZ010000001.1  265888925-265888980
            446-590             JAXUCZ010000001.1  265892382-265892526
            591-696             JAXUCZ010000001.1  265893680-265893785
            697-760             JAXUCZ010000001.1  265896331-265896394
            761-865             JAXUCZ010000001.1  265897265-265897369
            866-1048            JAXUCZ010000001.1  265897587-265897769
            1049-1192           JAXUCZ010000001.1  265898203-265898346
            1193-1364           JAXUCZ010000001.1  265898771-265898942
            1365-1451           JAXUCZ010000001.1  265899871-265899957
            1452-1619           JAXUCZ010000001.1  265902762-265902929
            1620-1727           JAXUCZ010000001.1  265903044-265903151
            1728-1898           JAXUCZ010000001.1  265903930-265904100
            1899-2141           JAXUCZ010000001.1  265905270-265905512
            2142-2279           JAXUCZ010000001.1  265905824-265905961
            2280-2390           JAXUCZ010000001.1  265908907-265909017
            2391-2561           JAXUCZ010000001.1  265909555-265909725
            2562-2834           JAXUCZ010000001.1  265912578-265912850
            2835-2954           JAXUCZ010000001.1  265914596-265914715
            2955-3071           JAXUCZ010000001.1  265915981-265916097
            3072-3170           JAXUCZ010000001.1  265918742-265918840
            3171-3398           JAXUCZ010000001.1  265920045-265920272
            3399-3445           JAXUCZ010000001.1  265920791-265920837
            3446-3538           JAXUCZ010000001.1  265920914-265921006
            3539-4778           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..4778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4778
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..56
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..389
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             86..3538
                     /gene="Tdrd1"
                     /note="isoform 2 is encoded by transcript variant 6; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 2"
                     /protein_id="NP_001425190.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNYGNVERLPFSRVQPITASHLQLPFRIIRCSLEGL
                     TELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNVHAVSVEKCSENGMINIAENLVMC
                     GLAENLSSKRESASTKETPHSTDCCCTELQKQIEKHEQILLFLLNNPTNQNKFIEMKK
                     LLQS"
     misc_feature    569..679
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    569..679
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    866..1255
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    866..1255
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1034..1036,1055..1057,1109..1111,1118..1120,
                     1124..1126)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1034..1036,1055..1057,1109..1111,1118..1120,
                     1124..1126)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1616..1861
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1616..1861
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1721..1723,1742..1744,1793..1795,1802..1804,
                     1808..1810)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1721..1723,1742..1744,1793..1795,1802..1804,
                     1808..1810)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2207..2557
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2207..2557
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2894..3172
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    2894..3172
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     exon            390..445
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..590
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..696
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..760
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..865
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1048
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1364
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1451
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1619
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1727
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1898
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2141
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2279
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2390
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2561
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2834
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2954
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3071
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3170
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3398
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3445
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3538
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..4778
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcgca ggcgcgggat caacagcacg cggcagcctt gagcgtccga ggcgagacgt
       61 cagtgaatgt taagttacat ctaatatgat gccacgaaat aatttggaag cctctacttg
      121 taaaatggca gaaccattta attttgagaa aaaggaaagc aaacttccac cccacgattc
      181 tctaagaagt cctgtaccac agcataacca tcccaatttc agactgaaaa gcccagagaa
      241 cggaaataaa aagaacaatt ttttgctttg tgaacaaaac aaacagtact tggctagtca
      301 ggaagacaat tcggtggtct cttcaaaccc tgctggtatc aatggagaag taggtgggtc
      361 caaaggagac aggaagacat taccaacagg aaacccagta tcattaagtc ttggaaacaa
      421 ttcaccacct aaccaagtaa aaactaagcc cagcaatgct gtgactcctg aaaaatcaaa
      481 aaaatctcac aagctgtttg agaatgcctt gtccgtaaat aacccagctc tcttcaactc
      541 gttaggaccg cccctgcggt ccacaacctg ccatcgctgt ggcctgttcg ggtcgctgag
      601 gtgttcccag tgcaagcaga catattactg ctccacagca tgccagagga gagactggtc
      661 ttcccatagc accatctgta gacctgtgca gcaaagtctg cataagcttg aagataataa
      721 gtcaccattt gaaacaaaga ccattgacgt gaagaatgag gttgcctgtc ccctgggagt
      781 tactaaagaa atgacagctg gtgcagagag agtaatgttt tctgatctga ggagtctcca
      841 actgaggaaa tccatggaaa taaagggcac agttactgaa ttcaagcacc cgggtcattt
      901 ttatgtccag ttgtattcct cagaggtttt agagtacatg aaccaactct ctgcaagttt
      961 gaaagagaca tatgcaaata tggtgcctga agacggatat cttcctgtta agggggaagt
     1021 ctgtgttgcc aagtacacgg ttgatcagac ctggaaccga gccgtagtag aaggcgtgga
     1081 cgtgctgcag aagaaggcac atgtcttgta catcgactac ggaaatgaag agatcatccc
     1141 agtcgacaga atccaccagc taagcagaag tatcagcctg tttccccctt ccgccataaa
     1201 gtgctatgtg tcaggagtcg tccccgctgc gggtgagtgg actgaagact gtgttgtagc
     1261 tgtcaaggct ctgctgttcg agcagtactg ctctatcaag gtcgtggaca tctcagagga
     1321 ggaggggctc acctgtgctg tcgacgtcgt gctgcagagt tcaggaaaac agctggacca
     1381 tgtgcttgtg gaaatgggat atggtgtgaa acctgatgag ccgagctcca agaagcaaag
     1441 tatggaccca ggcacttcgg aggacactgg aagactgaca gctgagaaca ggatcggggc
     1501 agagagaaat gccctggtcc ccacagtgct gactttgaat gtgggtgacg agttctgtgg
     1561 tgtagttgcc cacatccaga caccagagga cttcttttgt cagcagctgc agagtggcca
     1621 caagctcgcc gagcttcagg agtccctcag tgagtactgt agccacgtga ctccacgctc
     1681 agacttttat ccaaccattg gggacatgtg ttgtgctcag ttctcagagg atgaccaatg
     1741 gtaccgcgcc tcggttctgg cctatgcttc agaagaatct gtcctggttg gatatgtcga
     1801 ttatggaaac tttgaaattc ttagtttgaa aagactttgt cccataattc caaagttgtt
     1861 ggatttgccg atgcaagctt taaattgtgt gctggcagga gtgaagccat ctttaggaat
     1921 gtggactcca gaagccattt gtgtcatgag gaaggctgtg cagaacagga tggtgaccgt
     1981 gagagtggtg ggcatgcagg ggaccagggc cctggtggag ctcgtagaca aatcggtggc
     2041 tcctcacctc agcgcttcta aagctctgct agactccggc tttgccatcg aggaaaagga
     2101 catagtggca gataaaggca gcagtgcgcg tgcctcgaat gttcccttgg ctgtagaagg
     2161 agcagtggag gtgctggagt ggacgtgggt cgagttcacc gttgacgaga ctgtggacgt
     2221 gatggtctgc atgatgcaca gccctgggga gttctactgc cactgtctca aagacgacgc
     2281 cttaaagaag ctcgatgact tgaacaagtc cttagcagac tactgtgcac aaaaaccgcc
     2341 caatggcttc aaggcagagg tagggcggcc ttgctgtgcc tgttttgcag gtgacggcaa
     2401 ctggtaccgg gctctggtca aggagatcct accaagtggg aacgtcaaag tacactttgt
     2461 ggactacggc aatgttgaag aggttaccac agaccaactg cacgcaatag ccccccagtt
     2521 cttactactt ccgttccaag ggatgcagtg ctggctagta gatatacagc ccaaaaacaa
     2581 gcattggaca aaagaagcca cagcaagatt tcaagcatgt gtcgtggggc ttaaacttca
     2641 agccagagtt gtggaaatca cggagaatgg ggtgggcgtt gaactcaccg atctttccac
     2701 cccctacccc aaaatcatta gtgacgttct catcacagaa catctggtct taaggtgtgg
     2761 ttcaccacag aaggacgagt tgatgagcag acctgctaat aaacataacc agatcgactc
     2821 ccagagcgtg caagccagcc ctcctgcaga gcagtggaag accatagagt tgccagttaa
     2881 caagactgta ccagcaaatg tactagaaat cataagccca accttgtttt atgccatccc
     2941 cagtgaaatg ccagaaaatc aagaaaaact gtgtgtgttg acagctgaat tgttagaaca
     3001 ctgtaacgct cagaaaggcc agccacccta cagaccacgg acgggagaag cctgctgtgc
     3061 taaatacaca aattatggaa acgtggaaag actgcctttt tccagagtgc agcccatcac
     3121 tgccagccac ctgcagctgc ccttccgcat cattagatgc tcacttgagg ggctgacgga
     3181 gctgaacgga agcagttcgc agccagtgat ggagctgctg aggaacgcca tgctgaacca
     3241 gagtgtggct ctctctgtga aagcagtctc gaagaatgtc catgcagtgt cagttgaaaa
     3301 atgttctgaa aatggaatga tcaatatagc tgagaatctg gtgatgtgtg gcctggcaga
     3361 aaacctctca tctaaaaggg aaagtgcttc aactaaagaa acaccgcaca gcaccgattg
     3421 ctgctgcaca gagttacaga aacagattga gaaacacgaa cagattctcc tcttcctctt
     3481 aaacaatcca accaaccaaa ataaatttat agagatgaaa aagctgctgc aaagctaaaa
     3541 acatcatccc tggggaaaaa cactcgggaa gaaggagacc acaaaagcca gactagagaa
     3601 agaattgtat cttgtgtttg ttcgctggaa ctgttgcttc ctctcctttc cttagtgacc
     3661 tttgacctca ccacccctac ttacttacct tgttctgttg ggtttgttgc cctctccctg
     3721 attctttcca caaaatacat gaatcttgca taagaggttc atgtactagc taggcgtggt
     3781 ggtgcacacc tgtaatccca gccatgagca gaatgaggca agaagacctc aagttcaagg
     3841 ccagcatggg ctacatagat agtttctcat tacaaacaaa accaaacatc aagattcaaa
     3901 aaatgtatga gacgactagg aaggaacatg aggtatcttc tactaagagt gcgtgcatga
     3961 gtgcgcgtat gcgtgtgtgt gtgtgtgtat ttgctctact gagtatagaa gctagagcct
     4021 cccgtgtgtt aggcaagctt tccctctgag ctacagtccc agctctagca tctcgctgtc
     4081 cttgaaaggc tgggtggctg ccctgggcgg gcgggcttca gcatggtctg aacatcacag
     4141 gcctctgcta atgagatgct cttggtcatc tgccgcctcg tcccctgctg ggatctgatt
     4201 ggttctttgc ttctgggtgc catgcttcct ttgtgacttg tggccaagga tgtgtgctgc
     4261 tgctctcatc tgtgctgaga cagcttggct tttcatcttc gatcacagct tcagtcttgg
     4321 cactaggagg acactttctg cccctgccct cagaggccct cctgggattg tctcactagt
     4381 ctgtagtcat tcagacttaa gctctagaaa taattcacta ttttctcaaa cacaaactcc
     4441 agatatcgat ttaaaaatgg agagcacatt tgtcatagtt catgatcaca gattgtccca
     4501 accttagcca tgggcagcag tgtgtgcctt cctgacagtc ccatagtcgc tctggcaatt
     4561 gtcccacggt ttcagtgctg tgcggcactg tgacaactta atacaacatc cccagcactg
     4621 atattgatgt gggtgggttt gttccatttc cttttactgg caatgtgtgt cagctcttct
     4681 gttaaatagg acttctcacg taaacagttg cttgaatgtt gatgtgcctc aaacagctaa
     4741 gtttgtcctg attcatccag taaactcact tgtcttca
//
LOCUS       NM_001438299             826 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12),
            transcript variant 3, mRNA.
ACCESSION   NM_001438299 XM_006228651
VERSION     NM_001438299.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228651.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM065363.1, SRR26643289.1327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  93156168-93156306   c
            140-207             JAXUCZ010000001.1  93155999-93156066   c
            208-826             JAXUCZ010000001.1  93153424-93154042   c
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..826
                     /gene="Mrps12"
                     /note="mitochondrial ribosomal protein S12"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
     exon            1..139
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Mrps12"
                     /note="upstream in-frame stop codon"
     exon            140..207
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..578
                     /gene="Mrps12"
                     /note="isoform 1 is encoded by transcript variant 3; 28S
                     ribosomal protein S12, mitochondrial; small ribosomal
                     subunit protein uS12m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12m isoform 1"
                     /protein_id="NP_001425228.1"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
                     /translation="MSWPGLLHGLTTSLSRGLALAPQLWATRSMATLNQMHRLGRPKE
                     PPKRLGPTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTL
                     QEHHVVLVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK"
     misc_feature    252..572
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    252..572
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    order(255..260,264..269,276..281)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    order(255..260,264..269,276..281)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    255..257
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    255..257
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    order(279..287,318..320,324..329,333..335,378..383,
                     387..395,414..416,438..440,447..452,489..494,504..509,
                     570..572)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(279..287,318..320,324..329,333..335,378..383,
                     387..395,414..416,438..440,447..452,489..494,504..509,
                     570..572)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(369..374,504..506)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(369..374,504..506)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    372..377
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    372..377
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(375..392,450..476)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     misc_feature    order(375..392,450..476)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     exon            208..826
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgaccct gctagtttgg taaggtgggt gcacttatct gtgatccaga catgtctcat
       61 ctctcctcag tttccccttc cagtattcgg gcgagggcga ttgggtcctt gcgggcctac
      121 tcagagtgag actgaatttg gacgcagcct gcggcgagat gtcctggccc ggccttctcc
      181 atggcctcac cacgtccctc agtcgtggcc tagccctagc tccccagctc tgggccaccc
      241 gttccatggc caccctgaac cagatgcacc gcttaggccg cccgaaggaa ccccctaagc
      301 gtctgggccc cacggagggc cggccccagc tgaagggtgt ggtgttgcgc acatttatca
      361 ggaagccgaa gaagcccaac tccgccaacc ggaagtgctg ccgagtacgc ctcagcaccg
      421 gcaaagaggc tgtctgcttc atccccggcg agggccacac cctgcaggag caccacgtgg
      481 tcctcgtgga gggtggtcgc acccaggacc tgcctggggt taaactcaaa gttgtgaggg
      541 gcaagtatga ctgcggccac gtgcagaaga agaaatgacc ataattcaca gtgatctgct
      601 actggatcct tggaaacggg ttctttctgc tccaggggca gcttttcttg ggttcaaatc
      661 ttactctgac tcagcaagat gctattaacc tgcaagattt ctgaaggtga attggaagga
      721 ggaactcttg tgcccactcc cttgacttcc atgttcagtg tctgcaggtt gacctcatgc
      781 gctgggatgg gggttgtaat aaacatatct tcaggttgtg atgtca
//
LOCUS       NM_001013069            1320 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus StAR-related lipid transfer domain containing 10
            (Stard10), transcript variant 2, mRNA.
ACCESSION   NM_001013069 XM_215005
VERSION     NM_001013069.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Ito,M., Yamanashi,Y., Toyoda,Y., Izumi-Nakaseko,H., Oda,S.,
            Sugiyama,A., Kuroda,M., Suzuki,H., Takada,T. and Adachi-Akahane,S.
  TITLE     Disruption of Stard10 gene alters the PPARalpha-mediated bile acid
            homeostasis
  JOURNAL   Biochim Biophys Acta 1831 (2), 459-468 (2013)
   PUBMED   23200860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001013069.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091411.1, SRR22582416.160633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000001.1  165134668-165134833
            167-486             JAXUCZ010000001.1  165134991-165135310
            487-634             JAXUCZ010000001.1  165155405-165155552
            635-738             JAXUCZ010000001.1  165156043-165156146
            739-856             JAXUCZ010000001.1  165156758-165156875
            857-909             JAXUCZ010000001.1  165158462-165158514
            910-1320            JAXUCZ010000001.1  165158724-165159134
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1320
                     /gene="Stard10"
                     /note="StAR-related lipid transfer domain containing 10"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
     exon            1..166
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    163..165
                     /gene="Stard10"
                     /note="upstream in-frame stop codon"
     exon            167..486
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1152
                     /gene="Stard10"
                     /note="isoform 1 is encoded by transcript variant 2; START
                     domain containing 10; PCTP-like protein; StAR-related
                     lipid transfer (START) domain containing 10; START
                     domain-containing protein 10"
                     /codon_start=1
                     /product="START domain-containing protein 10 isoform 1"
                     /protein_id="NP_001013087.1"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
                     /translation="MEKPAASTEPQGPRPALGRESVQVPDDQDFRSFRSECEAEVGWN
                     LTYSKAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIET
                     FDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKD
                     LVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKA
                     CIKYPEWKQKHQPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVTESREERA
                     GGAGEGSDDDTSLT"
     misc_feature    334..1002
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    334..1002
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    order(415..420,439..441,481..483,487..489,523..525,
                     535..537,553..555,562..567,571..576,631..633,637..648,
                     652..654,661..663,667..669,673..675,718..720,769..771,
                     775..786,790..792,826..828,832..834,838..840,844..846,
                     850..852,856..858,877..879,883..891,895..903,910..915,
                     922..924)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     misc_feature    order(415..420,439..441,481..483,487..489,523..525,
                     535..537,553..555,562..567,571..576,631..633,637..648,
                     652..654,661..663,667..669,673..675,718..720,769..771,
                     775..786,790..792,826..828,832..834,838..840,844..846,
                     850..852,856..858,877..879,883..891,895..903,910..915,
                     922..924)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     exon            487..634
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            635..738
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            739..856
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            857..909
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1320
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccccgc gcagcttgct gccgagttag ttgtgcgagt ccggccagca ccgcgcgggg
       61 actccgtgcc agacccgcac ctgcgatccc cagagtcccg cccggctctc gcgggctcct
      121 gcacccgcta cgcagcaacc ctactgccgc tccagggaag tatgaggtcc caggaaggtg
      181 gcgtcagcat ctgcagccgc gccgacgttg tctgagcctc cgcggaggac ccaggagagt
      241 cggactagga ccagggcccc gggcctcccc acgctctcta tggaaaagcc agctgcttca
      301 acagaacccc aagggcctcg gcccgctttg ggccgtgaaa gtgtccaggt gcccgatgac
      361 caggacttcc gcagttttcg gtcagagtgt gaggccgagg tgggctggaa cctgacctac
      421 agcaaggccg gtgtgtctgt gtgggtgcag gctgtggaga tggatcgaac tctgcacaag
      481 atcaagtgca ggatggaatg ctgtgacgta ccagctgaga cgctctacga tgtcctgcac
      541 gacatagaat accgaaagaa gtgggacagt aatgtcatcg agacattcga catcgctcga
      601 ctgactgtca acgctgacgt aggatattac tcctggaggt gtcccaagcc cctgaagaac
      661 cgtgatgtca tcaccctccg ctcctggctc cccatgggcg ctgattacat cattatgaac
      721 tactcagtga aacaccctaa atacccacct cggaaagact tggtccgagc tgtgtccatc
      781 cagacgggct acctcatcca gagcacgggg cccaagagct gtgtcatcac ctacctggcc
      841 caagtggacc ccaaaggctc cttacccaag tgggtggtga ataagtcatc tcagttcctg
      901 gcccccaagg ccatgaagaa gatgtacaag gcctgcatca agtaccctga gtggaagcag
      961 aaacaccagc cacatttcaa gccatggctg cacccggagc agagcccgtt acccagcctg
     1021 gcgctgtcag agctgtcggt gcaacacgca gactcactgg agaacatcga cgagagcgcc
     1081 gtgacagaga gccgggagga gcgggcgggt ggagcaggag agggcagcga tgacgacacc
     1141 tcgctcacct gagaaccgcc tctcttcaag gaccaagaca ggactggggt ggaaccctgg
     1201 ggcactgagc cttctgcact tcctcccttc ccccacctgc cttttggggg cactgggctc
     1261 ctgctcaggt ggctgcggca tggctggaca tggccccaat aaatgaacca cacagcccca
//
LOCUS       NM_001438272            3439 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus FLT3-interacting zinc finger 1 (Fiz1), transcript
            variant 3, mRNA.
ACCESSION   NM_001438272 XM_006228254
VERSION     NM_001438272.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3439)
  AUTHORS   Tsuruyama,T., Imai,Y., Takeuchi,H., Hiratsuka,T., Maruyama,Y.,
            Kanaya,K., Kaszynski,R., Jin,G., Okuno,T., Ozeki,M., Nakamura,T.,
            Takakuwa,T., Manabe,T., Tamaki,K. and Hiai,H.
  TITLE     Dual retrovirus integration tagging: identification of new
            signaling molecules Fiz1 and Hipk2 that are involved in the IL-7
            signaling pathway in B lymphoblastic lymphomas
  JOURNAL   J Leukoc Biol 88 (1), 107-116 (2010)
   PUBMED   20360400
REFERENCE   2  (bases 1 to 3439)
  AUTHORS   Wolf,I. and Rohrschneider,L.R.
  TITLE     Fiz1, a novel zinc finger protein interacting with the receptor
            tyrosine kinase Flt3
  JOURNAL   J Biol Chem 274 (30), 21478-21484 (1999)
   PUBMED   10409713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228254.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.319.1, SRR26643292.984.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               JAXUCZ010000001.1  77857625-77858546
            923-1258            JAXUCZ010000001.1  77859036-77859371
            1259-3439           JAXUCZ010000001.1  77862383-77864563
FEATURES             Location/Qualifiers
     source          1..3439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3439
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="FLT3-interacting zinc finger 1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
     exon            1..922
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    899..901
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="upstream in-frame stop codon"
     exon            923..1258
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     CDS             956..2449
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Flt3 interacting zinc finger protein 1"
                     /codon_start=1
                     /product="flt3-interacting zinc finger protein 1"
                     /protein_id="NP_001425201.1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
                     /translation="MDDPSLPVVPAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRH
                     FARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQV
                     VHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNV
                     GPCSVCGGGGSGGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAA
                     HWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSSAPPTQVWASGGAPEVAGEG
                     DTAEVGATPPTWDAGLLLSPTGAGVPKLEALLPEDEGAGNAQAPAAAAEASSEDTLYQ
                     CDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGKGSGEAAP
                     DGEGEQVAGGPGPGSSSRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGK
                     FFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD"
     misc_feature    1031..1099
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1031..1099
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1037..1099
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1037..1099
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1073..1150
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1073..1150
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1121..1183
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1121..1183
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1136..1138,1142..1144,1148..1150,1154..1159,
                     1166..1171,1178..1180,1220..1222,1226..1228,1238..1243,
                     1250..1255,1262..1264,1304..1306,1310..1312,1316..1318,
                     1322..1327,1334..1339)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1136..1138,1142..1144,1148..1150,1154..1159,
                     1166..1171,1178..1180,1220..1222,1226..1228,1238..1243,
                     1250..1255,1262..1264,1304..1306,1310..1312,1316..1318,
                     1322..1327,1334..1339)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1157..1228
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1157..1228
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1205..1267
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1205..1267
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1289..1345
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1289..1345
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1562..1624
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1562..1624
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    order(1577..1579,1583..1585,1589..1591,1595..1600,
                     1607..1612,1619..1621,1661..1663,1667..1675,1679..1684,
                     1694..1696,1703..1705)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    order(1577..1579,1583..1585,1589..1591,1595..1600,
                     1607..1612,1619..1621,1661..1663,1667..1675,1679..1684,
                     1694..1696,1703..1705)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    1646..1708
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1646..1708
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    2204..2266
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2204..2266
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(2219..2221,2225..2227,2231..2233,2237..2242,
                     2249..2254,2261..2263,2303..2305,2309..2311,2321..2326,
                     2333..2338,2345..2347,2387..2389,2393..2395,2399..2401,
                     2405..2410,2417..2422,2429..2431)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(2219..2221,2225..2227,2231..2233,2237..2242,
                     2249..2254,2261..2263,2303..2305,2309..2311,2321..2326,
                     2333..2338,2345..2347,2387..2389,2393..2395,2399..2401,
                     2405..2410,2417..2422,2429..2431)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    2240..2317
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2240..2317
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    2288..2350
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2288..2350
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2366..2434
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    2366..2434
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    2372..2434
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2372..2434
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1259..3439
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggaagt gacgctgacc tcgctgccca aaatgtcggc gcccagaggg aggtgtaagt
       61 aattaaacag gaaagcggac agactttccc ggcctcccgg ggtcctgcct ggtctccaag
      121 acctccgcaa cgcaaaagca aggtggtctc gcctagtccc ccggccgcct gacctgcccc
      181 cgccctggac gccggagact gcaccttcta gggacaggga aaggggtaca aagggccagt
      241 tttccgggcc ttgttcgaaa gatcgagcgg gggagggggg cttgcagcac ctcacactat
      301 gggggtgcag ggggcggagc ttatggtggt tggggcgggg cagaactgga ggaggagctt
      361 gttgaggcgt ggtttatagt ctgagaggag gggtttcaag aaagggtaga tagagactgg
      421 ttagaaaatg gaatacaaag tggggcctag taaagaggcg tgaatcacat gcaatggggg
      481 aaagggcctt ggttgaaaaa atttaagaaa cttatttagg ttagtgggaa agtggggtcc
      541 agtaagacaa gagaggccca gagtatgttg tgtgaagttt gcctgaggtg tgacctagag
      601 aaaagctcac catgacaagg aggctgatgt atgtgtgcaa tttggaggct tttagtagaa
      661 ccgtcaggtt tttatcatga agttaaaaat gttgggaggg agcttagcgg caagctaaga
      721 aagtaatagg aaagtagagg tgattgtaga aaaagtccca gtgaagatct aacttagaaa
      781 agtcaaatta acttagaacc atacaagaat aaaggaagta agaggaactt cgtcagacta
      841 ctcagttaag tcctatctgt tcctcggctt tcctaagtgc gaggtacacc ttgctactta
      901 gctcaaacca tcactgtatg agagaaagcc ccaagctacc accaaacctc ccaccatgga
      961 tgacccctcg cttcctgtgg ttcctgctgc tccagggcca gcgccatctg ccactgcgcc
     1021 tcgggtcccc tttcactgca gcgaatgtgg caagagcttc cgttaccgat ccgacctgag
     1081 gcgccatttt gctcgacaca cagcgctcaa gccccacgca tgtcctcgat gcggcaaggg
     1141 cttcaagcat agcttcaact tggctaacca cctgcgctca cacaccggtg agcgacccta
     1201 ccgatgttcc gcctgcccta agggattccg agactccact ggcctgctgc accaccaggt
     1261 cgtccacact ggtgagaagc cctactgctg tttggtctgc gagctccgct tctcctctcg
     1321 ctccagcctg ggccgccatc tcaagcgtca gcaccggggc acacttccct ctcccctgca
     1381 gcctagcccg ggcctgcctc ccttgagctc cccctgctca gtatgttgca acgttggtcc
     1441 ctgctcagtt tgtggaggtg gagggtccgg tggaggagag ggcctggagg gagctggagc
     1501 gaccagctgg ggactggcag aggctgcagc agctgcggca gcttcgctgc ccccatttgc
     1561 atgtggtgcc tgtgccaggc gttttgacca tggtcgggag ctggcagccc actgggctgc
     1621 acacactgat gtgaagccat tcaagtgccc gcgttgtgag cgcgacttca atgcacctgc
     1681 gctgctggaa cgccacaagc tcacacacga cctgcagggg agcagtgcac ctccaacaca
     1741 ggtttgggcc tcgggtgggg ctccagaggt ggcaggagag ggtgacacag cggaggtggg
     1801 ggccacccca ccaacttggg acgccgggct actcctgagc cctactggtg caggcgttcc
     1861 caaactggag gcactgcttc ccgaggatga gggcgctggg aatgcccagg ctccggctgc
     1921 ggcagccgaa gcatcctcag aagacacact gtaccaatgc gactgcggga ccttcttcgc
     1981 gtctgcccct gctttagcca gccatctaga ggcgcactct ggcccagcca cgtacggctg
     2041 tggccattgc ggggcgctgt acgcagcact ggccgccctg gaggagcatc ggcgtgcaag
     2101 ccatggtaag ggcagcgggg aggcagcccc cgacggtgag ggtgagcagg tggctggagg
     2161 gcccggaccc ggttcctcca gccgtggcaa gaaaatcttt ggctgttctg agtgcgagaa
     2221 gttgttccgc tctcctcgag acctggaaag gcatgtgctg gtccatactg gggaaaagcc
     2281 attcccgtgc ctggagtgtg gcaagttctt ccgccatgag tgctacctca agcgtcaccg
     2341 gctgctgcat ggcacagagc ggcccttccc ctgccacatc tgtggcaagg gcttcatcac
     2401 gcttagcaac ctctccaggc acctgaagct acacaggggc atggactgaa taaccaggac
     2461 gcccctgccc actaagtcca gagccagacc atgagatgag ccaggcccct gcctggaaaa
     2521 atggtgccgc ccagaaccca cataggacca cagtgaagca tcttttagca aagggatcca
     2581 agaacataat tgttggggaa tttctctctg aaatctacag agactcttga ctttgagacc
     2641 cctggaatgt ggcatgttca aatcagctgg cctccgagac cggtgacgta gtaatgaaaa
     2701 cgggtctgca ctcacatctc tcagcagata acatgtgggc acctccatgg tgttaaccac
     2761 ccaccactcc ctgtgagcca tcattccagg tgaccttcat tagggaatgg gggtggggca
     2821 atatcttgaa ctcctccagg atcccctcca gatgatacct gtcagccact ggtggcccca
     2881 gaaaatgagt ataaccgaaa tctgccttcc ccccattttg cttcctatac tgaaagagga
     2941 ccagggtaga taccccccac cttcaattaa cccactatca gattaggtct cccttactgc
     3001 agaatggtct gaccctactg gtctccccca tcctaaacac tagattagac tggcccaaag
     3061 tctccccgct ctttaggttg tactgaccca gatgcacata ctcctatcca cttagaatgg
     3121 gctggtgtct ggaatggtta tggcctaacc ccactctcct tagagtaata gggcagacat
     3181 tcccttatgc tgtagagcgc aatcctttga ccacagttgt cccaatcctg tgacctggtg
     3241 gaggtggtag acattgaggt tttcctcccc cttgacttgt agtactttgg tcttcccatc
     3301 actacaactt gactctttgt tccaacgcca caaggggata ggggaacttg gccaggggtt
     3361 tctcccctgt gagcctcaac ctgacccctg acccctctcc ccaatgtctc tgggactcca
     3421 ataaacctca ttcaatcac
//
LOCUS       NM_001438328            1102 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus folate receptor beta (Folr2), transcript variant
            2, mRNA.
ACCESSION   NM_001438328 XM_008759703
VERSION     NM_001438328.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Pridans,C., Irvine,K.M., Davis,G.M., Lefevre,L., Bush,S.J. and
            Hume,D.A.
  TITLE     Transcriptomic Analysis of Rat Macrophages
  JOURNAL   Front Immunol 11, 594594 (2021)
   PUBMED   33633725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Lu,Y., Parker,N., Kleindl,P.J., Cross,V.A., Wollak,K., Westrick,E.,
            Stinnette,T.W., Gehrke,M.A., Wang,K., Santhapuram,H.K., You,F.,
            Hahn,S.J., Vaughn,J.F., Klein,P.J., Vlahov,I.R., Low,P.S. and
            Leamon,C.P.
  TITLE     Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate
            of the mTOR Inhibitor Everolimus
  JOURNAL   Mol Med 21 (1), 584-596 (2015)
   PUBMED   26181632
  REMARK    GeneRIF: EC0565 forms micellar aggregates in physiological buffers
            and demonstrates good water solubility as well as strong
            multivalent FR-binding capacity. EC0565 inhibited mTOR signaling in
            rat macrophages at nanomolar concentrations
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Shen,J., Hilgenbrink,A.R., Xia,W., Feng,Y., Dimitrov,D.S.,
            Lockwood,M.B., Amato,R.J. and Low,P.S.
  TITLE     Folate receptor-beta constitutes a marker for human proinflammatory
            monocytes
  JOURNAL   J Leukoc Biol 96 (4), 563-570 (2014)
   PUBMED   25015955
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Watkins,D. and Rosenblatt,D.S.
  TITLE     Update and new concepts in vitamin responsive disorders of folate
            transport and metabolism
  JOURNAL   J Inherit Metab Dis 35 (4), 665-670 (2012)
   PUBMED   22108709
  REMARK    Review article
REFERENCE   5  (bases 1 to 1102)
  AUTHORS   van der Heijden,J.W., Oerlemans,R., Dijkmans,B.A., Qi,H., van der
            Laken,C.J., Lems,W.F., Jackman,A.L., Kraan,M.C., Tak,P.P.,
            Ratnam,M. and Jansen,G.
  TITLE     Folate receptor beta as a potential delivery route for novel folate
            antagonists to macrophages in the synovial tissue of rheumatoid
            arthritis patients
  JOURNAL   Arthritis Rheum 60 (1), 12-21 (2009)
   PUBMED   19116913
REFERENCE   6  (bases 1 to 1102)
  AUTHORS   Page,S.T., Owen,W.C., Price,K. and Elwood,P.C.
  TITLE     Expression of the human placental folate receptor transcript is
            regulated in human tissues. Organization and full nucleotide
            sequence of the gene
  JOURNAL   J Mol Biol 229 (4), 1175-1183 (1993)
   PUBMED   8445646
  REMARK    Erratum:[J Mol Biol 1994 May 13;238(4):639]
REFERENCE   7  (bases 1 to 1102)
  AUTHORS   Antony,A.C., Kane,M.A., Portillo,R.M., Elwood,P.C. and
            Kolhouse,J.F.
  TITLE     Studies of the role of a particulate folate-binding protein in the
            uptake of 5-methyltetrahydrofolate by cultured human KB cells
  JOURNAL   J Biol Chem 260 (28), 14911-14917 (1985)
   PUBMED   4066659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_008759703.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.891525.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  165617618-165617744 c
            128-314             JAXUCZ010000001.1  165616147-165616333 c
            315-503             JAXUCZ010000001.1  165612865-165613053 c
            504-639             JAXUCZ010000001.1  165612642-165612777 c
            640-1102            JAXUCZ010000001.1  165612051-165612513 c
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1102
                     /gene="Folr2"
                     /note="folate receptor beta"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
     exon            1..127
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..314
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..158
                     /gene="Folr2"
                     /note="upstream in-frame stop codon"
     CDS             168..926
                     /gene="Folr2"
                     /note="folate receptor 2 (fetal)"
                     /codon_start=1
                     /product="folate receptor beta precursor"
                     /protein_id="NP_001425257.1"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
                     /translation="MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPED
                     KLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYEC
                     SPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGIN
                     KCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEV
                     VKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD"
     sig_peptide     168..227
                     /gene="Folr2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    252..779
                     /gene="Folr2"
                     /note="Folate receptor family; Region: Folate_rec;
                     pfam03024"
                     /db_xref="CDD:397250"
     misc_feature    252..779
                     /gene="Folr2"
                     /note="Folate receptor family; Region: Folate_rec;
                     pfam03024"
                     /db_xref="CDD:397250"
     exon            315..503
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..639
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1102
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgtgct tacagagcct ctatgccggg ctgtggataa agactgtgaa gactgcacag
       61 ggtctgatct agggagaggc caactctgat acccctatgt gcgctgctag gagctaagga
      121 cattcaggtc tctccaactg tagcttcctc tgccctgaca gagagacatg gcctggaaac
      181 agacaccact cctgcttttg gtctacatga tcacaacatg cagtgcccgg gacagaacag
      241 acctgctcaa cgtttgcatg gatgccaagc accataagac aaagccaggc ccggaggaca
      301 agctgcatga ccagtgtagt ccatggaaga gaaatgcctg ctgctcagtc aacaccagcc
      361 aggagctaca caaggacaac tcccgtctgt acaatttcaa ttgggatcac tgtggtgaga
      421 tgacgcccgc ctgtaagcgt cacttcatcc aagacgcctg cctgtatgag tgttccccca
      481 atcttgggcc ttggattcag caggcaggcc agagctggcg caaagagcgc ttcctggatg
      541 tgcccttatg caaagaggac tgtcaggagt ggtgggaagc ctgtcgtacc tcctttacct
      601 gcaagagaga ctggcataaa ggctgggact ggacctcagg cattaacaag tgcccagaca
      661 cagcaccctg ccgcacattt cagtactatt tcccgacacc agccagcctt tgtgagggtc
      721 tctggagtca ctcctacaag gtcagcaact atagcagagg gagtggccag tgcatccaga
      781 tgtggtttga ctcaacccag ggcaatccca atgaggaagt ggtgaagttc tatgcttcct
      841 ttatgacatc tgggactgtg taccatgcag caatacttct tgtgcccagc ctggccccag
      901 tgctgtcatt atggctccct gactgaggcc agtcttctcc tctagctacc cttggtctcg
      961 gttggttcaa ctcttcaaag aataaggaag tcttgagcct gcttccaccc ctctcctctg
     1021 ccatccagtt cctgatccat gttggggctt ggggtttcta caacaatcat tttcaataaa
     1081 tctatgacac atctcggcct aa
//
LOCUS       NM_001106202            5011 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 3, mRNA.
ACCESSION   NM_001106202 XM_001063929 XM_217641
VERSION     NM_001106202.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 5011)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 5011)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 5011)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 5011)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 5011)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 5011)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 5011)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001106202.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.9503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000001.1  265880993-265881212
            221-553             JAXUCZ010000001.1  265885603-265885935
            554-609             JAXUCZ010000001.1  265888925-265888980
            610-754             JAXUCZ010000001.1  265892382-265892526
            755-860             JAXUCZ010000001.1  265893680-265893785
            861-924             JAXUCZ010000001.1  265896331-265896394
            925-1029            JAXUCZ010000001.1  265897265-265897369
            1030-1212           JAXUCZ010000001.1  265897587-265897769
            1213-1356           JAXUCZ010000001.1  265898203-265898346
            1357-1528           JAXUCZ010000001.1  265898771-265898942
            1529-1615           JAXUCZ010000001.1  265899871-265899957
            1616-1783           JAXUCZ010000001.1  265902762-265902929
            1784-1891           JAXUCZ010000001.1  265903044-265903151
            1892-2062           JAXUCZ010000001.1  265903930-265904100
            2063-2305           JAXUCZ010000001.1  265905270-265905512
            2306-2443           JAXUCZ010000001.1  265905824-265905961
            2444-2554           JAXUCZ010000001.1  265908907-265909017
            2555-2725           JAXUCZ010000001.1  265909555-265909725
            2726-2998           JAXUCZ010000001.1  265912578-265912850
            2999-3118           JAXUCZ010000001.1  265914596-265914715
            3119-3235           JAXUCZ010000001.1  265915981-265916097
            3236-3403           JAXUCZ010000001.1  265918673-265918840
            3404-3631           JAXUCZ010000001.1  265920045-265920272
            3632-3678           JAXUCZ010000001.1  265920791-265920837
            3679-3771           JAXUCZ010000001.1  265920914-265921006
            3772-5011           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..5011
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..220
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..553
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    235..237
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             250..3771
                     /gene="Tdrd1"
                     /note="isoform 1 is encoded by transcript variant 3; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 1"
                     /protein_id="NP_001099672.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSR
                     VQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNV
                     HAVSVEKCSENGMINIAENLVMCGLAENLSSKRESASTKETPHSTDCCCTELQKQIEK
                     HEQILLFLLNNPTNQNKFIEMKKLLQS"
     misc_feature    733..843
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    733..843
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    1030..1419
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    1030..1419
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1198..1200,1219..1221,1273..1275,1282..1284,
                     1288..1290)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1198..1200,1219..1221,1273..1275,1282..1284,
                     1288..1290)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1780..2025
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1780..2025
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1885..1887,1906..1908,1957..1959,1966..1968,
                     1972..1974)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1885..1887,1906..1908,1957..1959,1966..1968,
                     1972..1974)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2371..2721
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2371..2721
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    3058..3405
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    3058..3405
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    order(3229..3231,3244..3246,3250..3252,3298..3300,
                     3307..3309,3313..3315)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     misc_feature    order(3229..3231,3244..3246,3250..3252,3298..3300,
                     3307..3309,3313..3315)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     exon            554..609
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..754
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..860
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..924
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1029
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1212
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1356
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1528
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1615
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1783
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1891
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2062
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2305
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2443
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2554
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2725
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2998
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3118
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3235
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3403
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3631
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3678
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3771
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..5011
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgaggcg aggtgagcac gggtgaagct cttggacttc ggggctgcgg ggtatggcaa
       61 acaccggcgt gagtgattag ccttagagac cgatcagggc cagcgccctt tcgccttttt
      121 ctgggtcagg cggcctggtc gccaaggcgc gggagctcgg tgtcaagatc gcctcgggcg
      181 tggatcgtta ggagccggaa gtccagagct ggacgttgag acgtcagtga atgttaagtt
      241 acatctaata tgatgccacg aaataatttg gaagcctcta cttgtaaaat ggcagaacca
      301 tttaattttg agaaaaagga aagcaaactt ccaccccacg attctctaag aagtcctgta
      361 ccacagcata accatcccaa tttcagactg aaaagcccag agaacggaaa taaaaagaac
      421 aattttttgc tttgtgaaca aaacaaacag tacttggcta gtcaggaaga caattcggtg
      481 gtctcttcaa accctgctgg tatcaatgga gaagtaggtg ggtccaaagg agacaggaag
      541 acattaccaa caggaaaccc agtatcatta agtcttggaa acaattcacc acctaaccaa
      601 gtaaaaacta agcccagcaa tgctgtgact cctgaaaaat caaaaaaatc tcacaagctg
      661 tttgagaatg ccttgtccgt aaataaccca gctctcttca actcgttagg accgcccctg
      721 cggtccacaa cctgccatcg ctgtggcctg ttcgggtcgc tgaggtgttc ccagtgcaag
      781 cagacatatt actgctccac agcatgccag aggagagact ggtcttccca tagcaccatc
      841 tgtagacctg tgcagcaaag tctgcataag cttgaagata ataagtcacc atttgaaaca
      901 aagaccattg acgtgaagaa tgaggttgcc tgtcccctgg gagttactaa agaaatgaca
      961 gctggtgcag agagagtaat gttttctgat ctgaggagtc tccaactgag gaaatccatg
     1021 gaaataaagg gcacagttac tgaattcaag cacccgggtc atttttatgt ccagttgtat
     1081 tcctcagagg ttttagagta catgaaccaa ctctctgcaa gtttgaaaga gacatatgca
     1141 aatatggtgc ctgaagacgg atatcttcct gttaaggggg aagtctgtgt tgccaagtac
     1201 acggttgatc agacctggaa ccgagccgta gtagaaggcg tggacgtgct gcagaagaag
     1261 gcacatgtct tgtacatcga ctacggaaat gaagagatca tcccagtcga cagaatccac
     1321 cagctaagca gaagtatcag cctgtttccc ccttccgcca taaagtgcta tgtgtcagga
     1381 gtcgtccccg ctgcgggtga gtggactgaa gactgtgttg tagctgtcaa ggctctgctg
     1441 ttcgagcagt actgctctat caaggtcgtg gacatctcag aggaggaggg gctcacctgt
     1501 gctgtcgacg tcgtgctgca gagttcagga aaacagctgg accatgtgct tgtggaaatg
     1561 ggatatggtg tgaaacctga tgagccgagc tccaagaagc aaagtatgga cccaggcact
     1621 tcggaggaca ctggaagact gacagctgag aacaggatcg gggcagagag aaatgccctg
     1681 gtccccacag tgctgacttt gaatgtgggt gacgagttct gtggtgtagt tgcccacatc
     1741 cagacaccag aggacttctt ttgtcagcag ctgcagagtg gccacaagct cgccgagctt
     1801 caggagtccc tcagtgagta ctgtagccac gtgactccac gctcagactt ttatccaacc
     1861 attggggaca tgtgttgtgc tcagttctca gaggatgacc aatggtaccg cgcctcggtt
     1921 ctggcctatg cttcagaaga atctgtcctg gttggatatg tcgattatgg aaactttgaa
     1981 attcttagtt tgaaaagact ttgtcccata attccaaagt tgttggattt gccgatgcaa
     2041 gctttaaatt gtgtgctggc aggagtgaag ccatctttag gaatgtggac tccagaagcc
     2101 atttgtgtca tgaggaaggc tgtgcagaac aggatggtga ccgtgagagt ggtgggcatg
     2161 caggggacca gggccctggt ggagctcgta gacaaatcgg tggctcctca cctcagcgct
     2221 tctaaagctc tgctagactc cggctttgcc atcgaggaaa aggacatagt ggcagataaa
     2281 ggcagcagtg cgcgtgcctc gaatgttccc ttggctgtag aaggagcagt ggaggtgctg
     2341 gagtggacgt gggtcgagtt caccgttgac gagactgtgg acgtgatggt ctgcatgatg
     2401 cacagccctg gggagttcta ctgccactgt ctcaaagacg acgccttaaa gaagctcgat
     2461 gacttgaaca agtccttagc agactactgt gcacaaaaac cgcccaatgg cttcaaggca
     2521 gaggtagggc ggccttgctg tgcctgtttt gcaggtgacg gcaactggta ccgggctctg
     2581 gtcaaggaga tcctaccaag tgggaacgtc aaagtacact ttgtggacta cggcaatgtt
     2641 gaagaggtta ccacagacca actgcacgca atagcccccc agttcttact acttccgttc
     2701 caagggatgc agtgctggct agtagatata cagcccaaaa acaagcattg gacaaaagaa
     2761 gccacagcaa gatttcaagc atgtgtcgtg gggcttaaac ttcaagccag agttgtggaa
     2821 atcacggaga atggggtggg cgttgaactc accgatcttt ccacccccta ccccaaaatc
     2881 attagtgacg ttctcatcac agaacatctg gtcttaaggt gtggttcacc acagaaggac
     2941 gagttgatga gcagacctgc taataaacat aaccagatcg actcccagag cgtgcaagcc
     3001 agccctcctg cagagcagtg gaagaccata gagttgccag ttaacaagac tgtaccagca
     3061 aatgtactag aaatcataag cccaaccttg ttttatgcca tccccagtga aatgccagaa
     3121 aatcaagaaa aactgtgtgt gttgacagct gaattgttag aacactgtaa cgctcagaaa
     3181 ggccagccac cctacagacc acggacggga gaagcctgct gtgctaaata cacaaatgat
     3241 gacttctggt accgggccat tgttctggaa gcgtcagact ctgatgtgaa agttctctat
     3301 gcagattatg gaaacgtgga aagactgcct ttttccagag tgcagcccat cactgccagc
     3361 cacctgcagc tgcccttccg catcattaga tgctcacttg aggggctgac ggagctgaac
     3421 ggaagcagtt cgcagccagt gatggagctg ctgaggaacg ccatgctgaa ccagagtgtg
     3481 gctctctctg tgaaagcagt ctcgaagaat gtccatgcag tgtcagttga aaaatgttct
     3541 gaaaatggaa tgatcaatat agctgagaat ctggtgatgt gtggcctggc agaaaacctc
     3601 tcatctaaaa gggaaagtgc ttcaactaaa gaaacaccgc acagcaccga ttgctgctgc
     3661 acagagttac agaaacagat tgagaaacac gaacagattc tcctcttcct cttaaacaat
     3721 ccaaccaacc aaaataaatt tatagagatg aaaaagctgc tgcaaagcta aaaacatcat
     3781 ccctggggaa aaacactcgg gaagaaggag accacaaaag ccagactaga gaaagaattg
     3841 tatcttgtgt ttgttcgctg gaactgttgc ttcctctcct ttccttagtg acctttgacc
     3901 tcaccacccc tacttactta ccttgttctg ttgggtttgt tgccctctcc ctgattcttt
     3961 ccacaaaata catgaatctt gcataagagg ttcatgtact agctaggcgt ggtggtgcac
     4021 acctgtaatc ccagccatga gcagaatgag gcaagaagac ctcaagttca aggccagcat
     4081 gggctacata gatagtttct cattacaaac aaaaccaaac atcaagattc aaaaaatgta
     4141 tgagacgact aggaaggaac atgaggtatc ttctactaag agtgcgtgca tgagtgcgcg
     4201 tatgcgtgtg tgtgtgtgtg tatttgctct actgagtata gaagctagag cctcccgtgt
     4261 gttaggcaag ctttccctct gagctacagt cccagctcta gcatctcgct gtccttgaaa
     4321 ggctgggtgg ctgccctggg cgggcgggct tcagcatggt ctgaacatca caggcctctg
     4381 ctaatgagat gctcttggtc atctgccgcc tcgtcccctg ctgggatctg attggttctt
     4441 tgcttctggg tgccatgctt cctttgtgac ttgtggccaa ggatgtgtgc tgctgctctc
     4501 atctgtgctg agacagcttg gcttttcatc ttcgatcaca gcttcagtct tggcactagg
     4561 aggacacttt ctgcccctgc cctcagaggc cctcctggga ttgtctcact agtctgtagt
     4621 cattcagact taagctctag aaataattca ctattttctc aaacacaaac tccagatatc
     4681 gatttaaaaa tggagagcac atttgtcata gttcatgatc acagattgtc ccaaccttag
     4741 ccatgggcag cagtgtgtgc cttcctgaca gtcccatagt cgctctggca attgtcccac
     4801 ggtttcagtg ctgtgcggca ctgtgacaac ttaatacaac atccccagca ctgatattga
     4861 tgtgggtggg tttgttccat ttccttttac tggcaatgtg tgtcagctct tctgttaaat
     4921 aggacttctc acgtaaacag ttgcttgaat gttgatgtgc ctcaaacagc taagtttgtc
     4981 ctgattcatc cagtaaactc acttgtcttc a
//
LOCUS       NM_001438278            2962 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), transcript
            variant 3, mRNA.
ACCESSION   NM_001438278 XM_063283044
VERSION     NM_001438278.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063283044.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.1412.1,
                                           SRR26643293.1399.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  79143873-79144074   c
            203-381             JAXUCZ010000001.1  79140675-79140853   c
            382-493             JAXUCZ010000001.1  79138630-79138741   c
            494-714             JAXUCZ010000001.1  79137661-79137881   c
            715-810             JAXUCZ010000001.1  79135186-79135281   c
            811-883             JAXUCZ010000001.1  79134012-79134084   c
            884-959             JAXUCZ010000001.1  79133654-79133729   c
            960-1015            JAXUCZ010000001.1  79132689-79132744   c
            1016-1108           JAXUCZ010000001.1  79132406-79132498   c
            1109-1201           JAXUCZ010000001.1  79131894-79131986   c
            1202-1344           JAXUCZ010000001.1  79128304-79128446   c
            1345-1390           JAXUCZ010000001.1  79128125-79128170   c
            1391-1464           JAXUCZ010000001.1  79127788-79127861   c
            1465-2962           JAXUCZ010000001.1  79125564-79127061   c
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2962
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..202
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1429
                     /gene="Ttyh1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1 isoform 1"
                     /protein_id="NP_001425207.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
                     "
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    206..268
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    341..403
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    464..466
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    569..571
                     /gene="Ttyh1"
                     /note="Essential for the formation of the channel-pore.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); other site"
     misc_feature    719..781
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    797..859
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    926..928
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    1139..1141
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    1247..1309
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    1358..1426
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1394..1396
                     /gene="Ttyh1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); phosphorylation site"
     exon            203..381
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..714
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..810
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..959
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1015
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1344
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1390
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1464
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..2962
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccggct ccgcccgcgc cccgcacagc accgaggctc ccggcccggt ccgccccgct
       61 gcccctcccc ggggccatgg gggcaccccc gggctaccga ccctctgcct gggtgcatct
      121 cctccaccag ctgccccgtg ccgacttcca gctccgcccg gtgcccagcg gctttgctcc
      181 ccgcgaccaa gagtaccagc aggccctgct gctggtggca gccttggctg ggctgggttt
      241 gggcctgagc ctcatcttca tcgctgtcta cctcatccgc ttctgctgct gcaggcctcc
      301 agaaccccct ggggccaaga gtcccccacc cggaggaggc tgtgtcacct ggagctgcat
      361 tgctgccctt ctcgtgggct gtgcaggcat tggcattggt ttctatggta acagcgagac
      421 cagtgatggg gtgtcccagc tcagctcagc actgcagcat gccaaccaca cgctcagcac
      481 cattgatgac ttggtgctgg aaacggtaga gaggctgggt gaggctgtga ggacagagct
      541 gaccaccctg gaggaagtgt tgtcagaacg cgtggagctg gtggctgcca cccggggagc
      601 cagaaggcag gctgaggcag cagctcagca cctgcaaggc ctagccttct ggcagggagt
      661 gtccctgagc ccagtacagg tggctgagga tgtgactttc gtggaggagt acaggtggct
      721 ggcctatgtc ctcctgctgc tcttggtgct tctggtttgt ctcttcaccc tcctgggcct
      781 ggccaagcag agcaagtggc tggtggttgt gatgaccgcc atgagtctcc tggtgcttgt
      841 cctgagctgg ggttctatgg gcctagaggc tgccacagct gtgggtctca gtgacttctg
      901 ctccaaccca gacacctatg tgctgaactt gacccaggag gagacaggaa tcagttcaga
      961 catcctcaac tattatttcc tgtgcaacca ggcggtctcc aaccccttcc aacagaggct
     1021 gactctgtcc cagcgtgctc tagccagcat ccactctcag ctgcaaggcc tggagcggga
     1081 agctagccct caatttcctg ctgcacagaa gcccttgtta tccttggagg agacgctgaa
     1141 tgtgacagaa agaagcttcc accagttggt ggcactgctg cactgccgca gtctgcacaa
     1201 ggactatggc tcagcactcc gaggcctgtg tgaagatgcc ctagagggcc tgctgttcct
     1261 gatgctcttt tctctcctgt ctgccggggc cctagccacc actctttgca gcctgccccg
     1321 tgcctgggct ctcttcccac ccagtgatga ctacgatgac acagacgatg acgacccttt
     1381 caaccctcag gaatccaagc gctttgtgca gtggcagtct tccatctgag cccccctgcc
     1441 agtgtggcct gcctctcctc tttggaagag tcaaccttcc agtcacgtgg aatgttcaaa
     1501 gcctgctggg attaggaacg gtgtggaatc gaatcaactt gcttcctagc agctcatatc
     1561 ctacacaaga acgtcagaaa actaacgctt gtttcaggat agggacagaa atcttcagag
     1621 agaagtagaa tatttgctcg taatgctacc acggtgatgt aaagggagaa ggtttaagga
     1681 agataatata aatccagaca ggaaaagatg aggcaatcat caagttgtca agtaaaaaca
     1741 aacatggcag agtcaaaagg gaaatttatt gtctggggaa caattcctat gtagttctta
     1801 tttgttaaaa aaaaaaaaag tagcacacat gacaaaggaa aacattgttg ttaatagata
     1861 aacataattc aaaaagcttc tattatctaa caaaaaacag accaactcaa tttagtaata
     1921 agtaactgag atgaacgtac aaggaaacaa aatccccaag acaaaggata aaactgggga
     1981 tttttggttt tcattttggt ttttggtttt ttgagacagg ctttctttgt aatagacctg
     2041 ggtgtcctgg aactctttgt agaccaggct ggccttgacc tcacagagaa cagcctgcct
     2101 ctgcctccct agtactgaga ttaaagcatg tatcaccata tcaccagcta aaatgttcaa
     2161 gttctaatga ttagcaaaca cgatgtgcta ctttcccctt tctagtacct acttgttgtg
     2221 gactttaaag tggggtgttg gctggtgcta gtctggaggc tcagggaaaa agttctctga
     2281 atatgctgct cagaggcggt gaatcaccag ctatgtgaaa ataataatta aaacaaacaa
     2341 acaaaacaaa accctgctca catctcttaa cctggtaatc ctttggggca caagcttcca
     2401 gtaagagatg aacaggcaac ccttggctca gttaaaccct ggagacagaa atgttcacaa
     2461 aaggaagaac agtaatgtag agcaggatcc tcaagttcac agtggcaagt ggggtacaga
     2521 ggcaccaggg gtatccctgg ccctgtgctg gttggaagcc tctgggtcct agacctggca
     2581 ccactatgtt aatgtggaca agttatctga ctggttgaac ctcagttgaa tggtgaagca
     2641 aatgggtatc ataaatccag aaaacagctc ttgacatgat aggtaataag caggataaat
     2701 gcagcatgat gttctgggtt acattctggt gcacagaaaa cattagtagg aaaagtaccc
     2761 acttctaaag tctgcggctt agttcagagt attaaagcaa tgtcaatttc ttacttttaa
     2821 caaataaacc atggtgaatt cgaggtgtgg aatctagcaa taggggaaac tgggcagtgt
     2881 gctcaattcc tgtattacct ttgcaatttt tatttctgta aacttaaatt tattctaaaa
     2941 taaaagttca ttataaaaag ga
//
LOCUS       NM_001039003            2841 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 6, mRNA.
ACCESSION   NM_001039003 XM_225078
VERSION     NM_001039003.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2841)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 2841)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2841)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 2841)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2841)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 2841)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 2841)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 2841)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 2841)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 2841)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001039003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN13663594
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-283             JAXUCZ010000001.1  36702543-36702611
            284-409             JAXUCZ010000001.1  36703970-36704095
            410-563             JAXUCZ010000001.1  36705450-36705603
            564-652             JAXUCZ010000001.1  36706668-36706756
            653-833             JAXUCZ010000001.1  36707831-36708011
            834-876             JAXUCZ010000001.1  36709666-36709708
            877-1063            JAXUCZ010000001.1  36722626-36722812
            1064-1182           JAXUCZ010000001.1  36723647-36723765
            1183-1275           JAXUCZ010000001.1  36724215-36724307
            1276-1461           JAXUCZ010000001.1  36724407-36724592
            1462-2841           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..2841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2841
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    74..76
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     CDS             86..1606
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 4 is encoded by transcript variant 6;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 4"
                     /protein_id="NP_001034092.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKS
                     SLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLL
                     LELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKG
                     ASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAA
                     DYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFV
                     FNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRAT
                     NSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDR
                     DYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQ
                     ENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS"
     misc_feature    101..>235
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    101..>235
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    335..1600
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    335..1600
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(857..868,911..916,965..976,1079..1081,1598..1600)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(857..868,911..916,965..976,1079..1081,1598..1600)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(857..859,863..868)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(857..859,863..868)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(866..868,1457..1459,1592..1594,1598..1600)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(866..868,1457..1459,1592..1594,1598..1600)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(917..928,1139..1141,1145..1147,1244..1249,
                     1334..1339,1379..1381,1385..1387,1475..1477)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(917..928,1139..1141,1145..1147,1244..1249,
                     1334..1339,1379..1381,1385..1387,1475..1477)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(965..967,974..976,983..985)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(965..967,974..976,983..985)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1130..1132,1142..1153,1157..1159)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1130..1132,1142..1153,1157..1159)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            215..283
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            284..409
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            410..563
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..652
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            653..833
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            834..876
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1063
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1182
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1275
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1461
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2841
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagagctct ctaagtattc ctgctgtgtc
      241 cccagaatat ttggaggtct atcttcagga gtctcttggc caggatgaaa accaagcatc
      301 tgtgccacca tcagtcgatc caatttttca agttccaatt tcaaaagctg ttgagctgac
      361 tacaaacgat gccataaaga ccactctgct gttggaattg gacatctcaa aagtagagtt
      421 ttcccatcaa cctggagatt ccttcaatgt gatctgtcca aacagtggtt ctgaagtaga
      481 agacttgctg caaaggctgc agctggctga caaacaagca caccgggtca tcctgaaaat
      541 taagatggac accaagaaga aaggagcttc tctgccccag catgtgcctg aggggagttc
      601 tctccagttc atcttcacct ggtgtcttga aatacgagca gttcctaaaa aggctttttt
      661 gagggccctt tcggattaca ccagcgatgc cactgaaaag cggaggcttc aggagctctg
      721 cagtaagcag ggagcagctg attacaaccg cttcatccga gatgccagtg tctgcctgct
      781 agacctcctg cttaccttcc catcctgcca gcctccgctc aacctcctgc tggagcacct
      841 tcctaaactc cagcctcgac catactcgtg cgcaagctcc agcttactcc atccagacaa
      901 gcttcacttt gtgtttaaca tcgtagagct tccgtcgaac accactgcag cctcactgcg
      961 gaagggagtg tgcacaggct ggctagccac attggttgct ccatttcttc agccaaacac
     1021 agaagttttg actgcagacc atagtgatgc tctggctcct gagatactta tctctcctcg
     1081 ggcaacaaat tccttccact taccagatga cctgtcggcc cccatcataa tggtgggtcc
     1141 aggaactggt gtagccccct ttgttggctt cctgcagcac agagaaaaac tccaagaaca
     1201 acacccagac ggaaactttg gagcaatgtg gctgtttttt ggctgcagac ataaggacag
     1261 agactatttg ttcagggagg agctcaggca tttcctcaag actggggtct tgactcacct
     1321 gaaggtctca ttctcaagag atgctgcgcc tgaggaagag gaggaggccc cagcaaagta
     1381 tgtgcaagac aacctccagc atcacagcca gcaggtggcc aggaccctcc ttcaggagaa
     1441 tggctacatt tacgtgtgtg gagacgccaa gaatatggct aaggatgtac acgacgccct
     1501 tgtagaaatc ataagcaaag aagctggagt tgacaaacta gaagcaatga agacactggc
     1561 aaccttaaag caagaaaagc ggtatctgca ggatatctgg tcgtgaaact agaagggagg
     1621 tttcagtgtg cttgcttgct tgtttgtttt ttgaaatgcc aaaggacagt tgtacagaag
     1681 ataggttttg ggtatttctt ggcagaggct ttgtggggaa cagctcactt acaggtacca
     1741 ccgcctgata caatctcagg tttgtctccc actctgtgtc ccacccagca ccccactgtg
     1801 tggagcggag aggcagctct cagctggctc ccaaggagga cagatagtcg tcaatggctc
     1861 tgggcacatc gtggagagtt tgtggacatg ttctctttca atgaagtaca ttcagaggat
     1921 attcattctg atgatattta aattaataca gacatacaga gcatactttt gcatgtttgc
     1981 acttaattgt ggtttattat caaaattata tttctgataa aatattttaa ttttgaggta
     2041 atccttacaa aataagggtt tttatgctac tagaaatata ttttgaaata caattgaaat
     2101 tgtgctctgc cattttcatc atgttaactt ttagtgtcac agtcctacag cttaggggca
     2161 tttgcattcc cctgacaaag gcatgtgtgt acatctcagt aacatcatgc cctgttctcc
     2221 tggactctat tcatcaatgc tcctcactaa cagacttggt attccccaat acctgactgt
     2281 acttctgtga ttcagctcag agtaaagagc tccagttaga cttctaatac caaattctct
     2341 tgcaagtttc gaaaataaag catataaaag gattctgtgc cattgtgtgt atggttgctg
     2401 agacaaaact gggacaaagc aacttaatga gagatggtat ttctgctcac agttccagta
     2461 tgtggtccat ggtgctggtg aagtcatggt ggcagaagga gaagacaact ggtcatgtta
     2521 catccagtca gaaggaaacg acatgcatgc ctcactggct ttctcctttt cacacacact
     2581 gtctagaact ttcacacaca gaatgggtct gcctacatgt actgtgggtg ttcacctcag
     2641 cgtagtccag aggacctctc agcagtggtt tgtctccagt gaggccacag ccatcacatg
     2701 catgataaac tctccattca gtgtatagtt attgtcttgt ttaatagttc aacatttaaa
     2761 acacaactct gcctggtgag atgtcactaa gagactccct ggtcattata agaattaaag
     2821 atttgaaaaa ataatctcaa a
//
LOCUS       NM_001438252            3527 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 2, mRNA.
ACCESSION   NM_001438252
VERSION     NM_001438252.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3527)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3527)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3527)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3527)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3527)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3527)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3527)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3527)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3527)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3527)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.408.1, SRR26643291.357.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-368             JAXUCZ010000001.1  36697967-36698120
            369-486             JAXUCZ010000001.1  36699898-36700015
            487-590             JAXUCZ010000001.1  36700516-36700619
            591-969             JAXUCZ010000001.1  36702233-36702611
            970-1095            JAXUCZ010000001.1  36703970-36704095
            1096-1249           JAXUCZ010000001.1  36705450-36705603
            1250-1338           JAXUCZ010000001.1  36706668-36706756
            1339-1519           JAXUCZ010000001.1  36707831-36708011
            1520-1562           JAXUCZ010000001.1  36709666-36709708
            1563-1749           JAXUCZ010000001.1  36722626-36722812
            1750-1868           JAXUCZ010000001.1  36723647-36723765
            1869-1961           JAXUCZ010000001.1  36724215-36724307
            1962-2147           JAXUCZ010000001.1  36724407-36724592
            2148-3527           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3527
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            215..368
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            369..486
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            487..590
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    550..552
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     CDS             559..2292
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 2"
                     /protein_id="NP_001425181.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MFSCCGFVLTSLELVVEPWIDGLWPALTKHFKSLGGQEDMSDSD
                     TLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSELQEQNETNKNQPSRIEDFD
                     SSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAV
                     ELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHR
                     VILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEK
                     RRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCA
                     SSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSD
                     ALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFG
                     AMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNL
                     QHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLK
                     QEKRYLQDIWS"
     misc_feature    1021..2286
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    1021..2286
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1543..1554,1597..1602,1651..1662,1765..1767,
                     2284..2286)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1543..1554,1597..1602,1651..1662,1765..1767,
                     2284..2286)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1543..1545,1549..1554)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1543..1545,1549..1554)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1552..1554,2143..2145,2278..2280,2284..2286)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1552..1554,2143..2145,2278..2280,2284..2286)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1603..1614,1825..1827,1831..1833,1930..1935,
                     2020..2025,2065..2067,2071..2073,2161..2163)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1603..1614,1825..1827,1831..1833,1930..1935,
                     2020..2025,2065..2067,2071..2073,2161..2163)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1651..1653,1660..1662,1669..1671)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1651..1653,1660..1662,1669..1671)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1816..1818,1828..1839,1843..1845)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1816..1818,1828..1839,1843..1845)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            591..969
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1095
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1249
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1338
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1519
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1562
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1749
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1868
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1961
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2147
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..3527
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtatgat ctgaaaaccg aaactggccc
      241 tctggtgatg gttgtatcta ccacgggtac tggagaccca cccgacacag cccgcaagtt
      301 tgtgaaagaa atacacaaca agacactacc cacagacttc tttgctcacc tgtggtatgg
      361 attattgggt ttgggtgact cagaatacac atacttctgc aatggaggga aagtaattga
      421 taaacgactt caggagcttg gagcccagca tttctatgac actggacatg ccgatgactg
      481 cgtagggtct tcagcgttgt ccagtcacag tttgctgctc agcctttgac tgtctttgct
      541 gtagccagat agtcgtgcat gttttcttgt tgtggttttg ttttgaccag tttagagctc
      601 gtggtagaac catggattga tggactctgg cctgctctca caaagcactt taagtcactc
      661 ggaggacaag aagacatgag tgacagtgac acactcgcac aggcatcaga tgcccccttg
      721 agtatggcca tgaagccaga gttgttgcac atccagtcac aagttgaact tctaagttta
      781 gaagacgtgg ggaaaaggga ttctgagctt caggaacaaa atgagaccaa caagaatcag
      841 ccaagtcgga tcgaagactt tgactcttcg cttgttaact cggttccccc actctcacag
      901 agctctctaa gtattcctgc tgtgtcccca gaatatttgg aggtctatct tcaggagtct
      961 cttggccagg atgaaaacca agcatctgtg ccaccatcag tcgatccaat ttttcaagtt
     1021 ccaatttcaa aagctgttga gctgactaca aacgatgcca taaagaccac tctgctgttg
     1081 gaattggaca tctcaaaagt agagttttcc catcaacctg gagattcctt caatgtgatc
     1141 tgtccaaaca gtggttctga agtagaagac ttgctgcaaa ggctgcagct ggctgacaaa
     1201 caagcacacc gggtcatcct gaaaattaag atggacacca agaagaaagg agcttctctg
     1261 ccccagcatg tgcctgaggg gagttctctc cagttcatct tcacctggtg tcttgaaata
     1321 cgagcagttc ctaaaaaggc ttttttgagg gccctttcgg attacaccag cgatgccact
     1381 gaaaagcgga ggcttcagga gctctgcagt aagcagggag cagctgatta caaccgcttc
     1441 atccgagatg ccagtgtctg cctgctagac ctcctgctta ccttcccatc ctgccagcct
     1501 ccgctcaacc tcctgctgga gcaccttcct aaactccagc ctcgaccata ctcgtgcgca
     1561 agctccagct tactccatcc agacaagctt cactttgtgt ttaacatcgt agagcttccg
     1621 tcgaacacca ctgcagcctc actgcggaag ggagtgtgca caggctggct agccacattg
     1681 gttgctccat ttcttcagcc aaacacagaa gttttgactg cagaccatag tgatgctctg
     1741 gctcctgaga tacttatctc tcctcgggca acaaattcct tccacttacc agatgacctg
     1801 tcggccccca tcataatggt gggtccagga actggtgtag ccccctttgt tggcttcctg
     1861 cagcacagag aaaaactcca agaacaacac ccagacggaa actttggagc aatgtggctg
     1921 ttttttggct gcagacataa ggacagagac tatttgttca gggaggagct caggcatttc
     1981 ctcaagactg gggtcttgac tcacctgaag gtctcattct caagagatgc tgcgcctgag
     2041 gaagaggagg aggccccagc aaagtatgtg caagacaacc tccagcatca cagccagcag
     2101 gtggccagga ccctccttca ggagaatggc tacatttacg tgtgtggaga cgccaagaat
     2161 atggctaagg atgtacacga cgcccttgta gaaatcataa gcaaagaagc tggagttgac
     2221 aaactagaag caatgaagac actggcaacc ttaaagcaag aaaagcggta tctgcaggat
     2281 atctggtcgt gaaactagaa gggaggtttc agtgtgcttg cttgcttgtt tgttttttga
     2341 aatgccaaag gacagttgta cagaagatag gttttgggta tttcttggca gaggctttgt
     2401 ggggaacagc tcacttacag gtaccaccgc ctgatacaat ctcaggtttg tctcccactc
     2461 tgtgtcccac ccagcacccc actgtgtgga gcggagaggc agctctcagc tggctcccaa
     2521 ggaggacaga tagtcgtcaa tggctctggg cacatcgtgg agagtttgtg gacatgttct
     2581 ctttcaatga agtacattca gaggatattc attctgatga tatttaaatt aatacagaca
     2641 tacagagcat acttttgcat gtttgcactt aattgtggtt tattatcaaa attatatttc
     2701 tgataaaata ttttaatttt gaggtaatcc ttacaaaata agggttttta tgctactaga
     2761 aatatatttt gaaatacaat tgaaattgtg ctctgccatt ttcatcatgt taacttttag
     2821 tgtcacagtc ctacagctta ggggcatttg cattcccctg acaaaggcat gtgtgtacat
     2881 ctcagtaaca tcatgccctg ttctcctgga ctctattcat caatgctcct cactaacaga
     2941 cttggtattc cccaatacct gactgtactt ctgtgattca gctcagagta aagagctcca
     3001 gttagacttc taataccaaa ttctcttgca agtttcgaaa ataaagcata taaaaggatt
     3061 ctgtgccatt gtgtgtatgg ttgctgagac aaaactggga caaagcaact taatgagaga
     3121 tggtatttct gctcacagtt ccagtatgtg gtccatggtg ctggtgaagt catggtggca
     3181 gaaggagaag acaactggtc atgttacatc cagtcagaag gaaacgacat gcatgcctca
     3241 ctggctttct ccttttcaca cacactgtct agaactttca cacacagaat gggtctgcct
     3301 acatgtactg tgggtgttca cctcagcgta gtccagagga cctctcagca gtggtttgtc
     3361 tccagtgagg ccacagccat cacatgcatg ataaactctc cattcagtgt atagttattg
     3421 tcttgtttaa tagttcaaca tttaaaacac aactctgcct ggtgagatgt cactaagaga
     3481 ctccctggtc attataagaa ttaaagattt gaaaaaataa tctcaaa
//
LOCUS       NM_001438255            3409 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 5, mRNA.
ACCESSION   NM_001438255 XM_039102907
VERSION     NM_001438255.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3409)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_039102907.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.521.1, SRR26643296.345.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-354             JAXUCZ010000001.1  36697967-36698106
            355-472             JAXUCZ010000001.1  36699898-36700015
            473-851             JAXUCZ010000001.1  36702233-36702611
            852-977             JAXUCZ010000001.1  36703970-36704095
            978-1131            JAXUCZ010000001.1  36705450-36705603
            1132-1220           JAXUCZ010000001.1  36706668-36706756
            1221-1401           JAXUCZ010000001.1  36707831-36708011
            1402-1444           JAXUCZ010000001.1  36709666-36709708
            1445-1631           JAXUCZ010000001.1  36722626-36722812
            1632-1750           JAXUCZ010000001.1  36723647-36723765
            1751-1843           JAXUCZ010000001.1  36724215-36724307
            1844-2029           JAXUCZ010000001.1  36724407-36724592
            2030-3409           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3409
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            215..354
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    303..305
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     exon            355..472
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            473..851
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..2174
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 3 is encoded by transcript variant 5;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 3"
                     /protein_id="NP_001425184.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSE
                     LQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQ
                     ASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSG
                     SEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAV
                     PKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPP
                     LNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLAT
                     LVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFV
                     GFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSR
                     DAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEII
                     SKEAGVDKLEAMKTLATLKQEKRYLQDIWS"
     misc_feature    903..2168
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    903..2168
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1425..1436,1479..1484,1533..1544,1647..1649,
                     2166..2168)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1425..1436,1479..1484,1533..1544,1647..1649,
                     2166..2168)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1425..1427,1431..1436)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1425..1427,1431..1436)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1434..1436,2025..2027,2160..2162,2166..2168)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1434..1436,2025..2027,2160..2162,2166..2168)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1485..1496,1707..1709,1713..1715,1812..1817,
                     1902..1907,1947..1949,1953..1955,2043..2045)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1485..1496,1707..1709,1713..1715,1812..1817,
                     1902..1907,1947..1949,1953..1955,2043..2045)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1533..1535,1542..1544,1551..1553)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1533..1535,1542..1544,1551..1553)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1698..1700,1710..1721,1725..1727)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1698..1700,1710..1721,1725..1727)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            852..977
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1131
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1220
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1401
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1444
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1631
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1750
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1843
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2029
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..3409
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtatgat ctgaaaaccg aaactggccc
      241 tctggtgatg gttgtatcta ccacgggtac tggagaccca cccgacacag cccgcaagtt
      301 tgtgaaagaa atacacaaca agacactacc cacagacttc tttgctcacc tgtggtttgg
      361 gtgactcaga atacacatac ttctgcaatg gagggaaagt aattgataaa cgacttcagg
      421 agcttggagc ccagcatttc tatgacactg gacatgccga tgactgcgta ggtttagagc
      481 tcgtggtaga accatggatt gatggactct ggcctgctct cacaaagcac tttaagtcac
      541 tcggaggaca agaagacatg agtgacagtg acacactcgc acaggcatca gatgccccct
      601 tgagtatggc catgaagcca gagttgttgc acatccagtc acaagttgaa cttctaagtt
      661 tagaagacgt ggggaaaagg gattctgagc ttcaggaaca aaatgagacc aacaagaatc
      721 agccaagtcg gatcgaagac tttgactctt cgcttgttaa ctcggttccc ccactctcac
      781 agagctctct aagtattcct gctgtgtccc cagaatattt ggaggtctat cttcaggagt
      841 ctcttggcca ggatgaaaac caagcatctg tgccaccatc agtcgatcca atttttcaag
      901 ttccaatttc aaaagctgtt gagctgacta caaacgatgc cataaagacc actctgctgt
      961 tggaattgga catctcaaaa gtagagtttt cccatcaacc tggagattcc ttcaatgtga
     1021 tctgtccaaa cagtggttct gaagtagaag acttgctgca aaggctgcag ctggctgaca
     1081 aacaagcaca ccgggtcatc ctgaaaatta agatggacac caagaagaaa ggagcttctc
     1141 tgccccagca tgtgcctgag gggagttctc tccagttcat cttcacctgg tgtcttgaaa
     1201 tacgagcagt tcctaaaaag gcttttttga gggccctttc ggattacacc agcgatgcca
     1261 ctgaaaagcg gaggcttcag gagctctgca gtaagcaggg agcagctgat tacaaccgct
     1321 tcatccgaga tgccagtgtc tgcctgctag acctcctgct taccttccca tcctgccagc
     1381 ctccgctcaa cctcctgctg gagcaccttc ctaaactcca gcctcgacca tactcgtgcg
     1441 caagctccag cttactccat ccagacaagc ttcactttgt gtttaacatc gtagagcttc
     1501 cgtcgaacac cactgcagcc tcactgcgga agggagtgtg cacaggctgg ctagccacat
     1561 tggttgctcc atttcttcag ccaaacacag aagttttgac tgcagaccat agtgatgctc
     1621 tggctcctga gatacttatc tctcctcggg caacaaattc cttccactta ccagatgacc
     1681 tgtcggcccc catcataatg gtgggtccag gaactggtgt agcccccttt gttggcttcc
     1741 tgcagcacag agaaaaactc caagaacaac acccagacgg aaactttgga gcaatgtggc
     1801 tgttttttgg ctgcagacat aaggacagag actatttgtt cagggaggag ctcaggcatt
     1861 tcctcaagac tggggtcttg actcacctga aggtctcatt ctcaagagat gctgcgcctg
     1921 aggaagagga ggaggcccca gcaaagtatg tgcaagacaa cctccagcat cacagccagc
     1981 aggtggccag gaccctcctt caggagaatg gctacattta cgtgtgtgga gacgccaaga
     2041 atatggctaa ggatgtacac gacgcccttg tagaaatcat aagcaaagaa gctggagttg
     2101 acaaactaga agcaatgaag acactggcaa ccttaaagca agaaaagcgg tatctgcagg
     2161 atatctggtc gtgaaactag aagggaggtt tcagtgtgct tgcttgcttg tttgtttttt
     2221 gaaatgccaa aggacagttg tacagaagat aggttttggg tatttcttgg cagaggcttt
     2281 gtggggaaca gctcacttac aggtaccacc gcctgataca atctcaggtt tgtctcccac
     2341 tctgtgtccc acccagcacc ccactgtgtg gagcggagag gcagctctca gctggctccc
     2401 aaggaggaca gatagtcgtc aatggctctg ggcacatcgt ggagagtttg tggacatgtt
     2461 ctctttcaat gaagtacatt cagaggatat tcattctgat gatatttaaa ttaatacaga
     2521 catacagagc atacttttgc atgtttgcac ttaattgtgg tttattatca aaattatatt
     2581 tctgataaaa tattttaatt ttgaggtaat ccttacaaaa taagggtttt tatgctacta
     2641 gaaatatatt ttgaaataca attgaaattg tgctctgcca ttttcatcat gttaactttt
     2701 agtgtcacag tcctacagct taggggcatt tgcattcccc tgacaaaggc atgtgtgtac
     2761 atctcagtaa catcatgccc tgttctcctg gactctattc atcaatgctc ctcactaaca
     2821 gacttggtat tccccaatac ctgactgtac ttctgtgatt cagctcagag taaagagctc
     2881 cagttagact tctaatacca aattctcttg caagtttcga aaataaagca tataaaagga
     2941 ttctgtgcca ttgtgtgtat ggttgctgag acaaaactgg gacaaagcaa cttaatgaga
     3001 gatggtattt ctgctcacag ttccagtatg tggtccatgg tgctggtgaa gtcatggtgg
     3061 cagaaggaga agacaactgg tcatgttaca tccagtcaga aggaaacgac atgcatgcct
     3121 cactggcttt ctccttttca cacacactgt ctagaacttt cacacacaga atgggtctgc
     3181 ctacatgtac tgtgggtgtt cacctcagcg tagtccagag gacctctcag cagtggtttg
     3241 tctccagtga ggccacagcc atcacatgca tgataaactc tccattcagt gtatagttat
     3301 tgtcttgttt aatagttcaa catttaaaac acaactctgc ctggtgagat gtcactaaga
     3361 gactccctgg tcattataag aattaaagat ttgaaaaaat aatctcaaa
//
LOCUS       NM_001438301             643 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12),
            transcript variant 5, mRNA.
ACCESSION   NM_001438301
VERSION     NM_001438301.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.3644151.1,
                                           SRR26360194.322577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000001.1  93156283-93156306   c
            25-643              JAXUCZ010000001.1  93153424-93154042   c
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..643
                     /gene="Mrps12"
                     /note="mitochondrial ribosomal protein S12"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
     exon            1..24
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    21..23
                     /gene="Mrps12"
                     /note="upstream in-frame stop codon"
     exon            25..643
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..395
                     /gene="Mrps12"
                     /note="isoform 2 is encoded by transcript variant 5; 28S
                     ribosomal protein S12, mitochondrial; small ribosomal
                     subunit protein uS12m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12m isoform 2"
                     /protein_id="NP_001425230.1"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
                     /translation="MATLNQMHRLGRPKEPPKRLGPTEGRPQLKGVVLRTFIRKPKKP
                     NSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLVEGGRTQDLPGVKLKVVRGKYD
                     CGHVQKKK"
     misc_feature    69..389
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    69..389
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    order(72..77,81..86,93..98)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    order(72..77,81..86,93..98)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    72..74
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    72..74
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    order(96..104,135..137,141..146,150..152,195..200,
                     204..212,231..233,255..257,264..269,306..311,321..326,
                     387..389)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(96..104,135..137,141..146,150..152,195..200,
                     204..212,231..233,255..257,264..269,306..311,321..326,
                     387..389)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(186..191,321..323)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(186..191,321..323)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    189..194
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    189..194
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(192..209,267..293)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     misc_feature    order(192..209,267..293)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
ORIGIN      
        1 gtacgaccct gctagtttgg taaggcctag ccctagctcc ccagctctgg gccacccgtt
       61 ccatggccac cctgaaccag atgcaccgct taggccgccc gaaggaaccc cctaagcgtc
      121 tgggccccac ggagggccgg ccccagctga agggtgtggt gttgcgcaca tttatcagga
      181 agccgaagaa gcccaactcc gccaaccgga agtgctgccg agtacgcctc agcaccggca
      241 aagaggctgt ctgcttcatc cccggcgagg gccacaccct gcaggagcac cacgtggtcc
      301 tcgtggaggg tggtcgcacc caggacctgc ctggggttaa actcaaagtt gtgaggggca
      361 agtatgactg cggccacgtg cagaagaaga aatgaccata attcacagtg atctgctact
      421 ggatccttgg aaacgggttc tttctgctcc aggggcagct tttcttgggt tcaaatctta
      481 ctctgactca gcaagatgct attaacctgc aagatttctg aaggtgaatt ggaaggagga
      541 actcttgtgc ccactccctt gacttccatg ttcagtgtct gcaggttgac ctcatgcgct
      601 gggatggggg ttgtaataaa catatcttca ggttgtgatg tca
//
LOCUS       NM_001438279            3028 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), transcript
            variant 4, mRNA.
ACCESSION   NM_001438279 XM_017588893
VERSION     NM_001438279.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 3028)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 3028)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_017588893.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.1411.1,
                                           SRR26360176.932742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  79143873-79144074   c
            203-381             JAXUCZ010000001.1  79140675-79140853   c
            382-493             JAXUCZ010000001.1  79138630-79138741   c
            494-714             JAXUCZ010000001.1  79137661-79137881   c
            715-810             JAXUCZ010000001.1  79135186-79135281   c
            811-883             JAXUCZ010000001.1  79134012-79134084   c
            884-959             JAXUCZ010000001.1  79133654-79133729   c
            960-1015            JAXUCZ010000001.1  79132689-79132744   c
            1016-1108           JAXUCZ010000001.1  79132406-79132498   c
            1109-1201           JAXUCZ010000001.1  79131894-79131986   c
            1202-1344           JAXUCZ010000001.1  79128304-79128446   c
            1345-1418           JAXUCZ010000001.1  79127788-79127861   c
            1419-3028           JAXUCZ010000001.1  79125564-79127173   c
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3028
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..202
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1441
                     /gene="Ttyh1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1 isoform 2"
                     /protein_id="NP_001425208.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPRNPSALCSGSLPSEPPCQCGLPLLFGSA
                     LLCF"
     misc_feature    101..1348
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    101..1348
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     exon            203..381
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..714
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..810
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..959
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1015
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1344
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1418
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..3028
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccggct ccgcccgcgc cccgcacagc accgaggctc ccggcccggt ccgccccgct
       61 gcccctcccc ggggccatgg gggcaccccc gggctaccga ccctctgcct gggtgcatct
      121 cctccaccag ctgccccgtg ccgacttcca gctccgcccg gtgcccagcg gctttgctcc
      181 ccgcgaccaa gagtaccagc aggccctgct gctggtggca gccttggctg ggctgggttt
      241 gggcctgagc ctcatcttca tcgctgtcta cctcatccgc ttctgctgct gcaggcctcc
      301 agaaccccct ggggccaaga gtcccccacc cggaggaggc tgtgtcacct ggagctgcat
      361 tgctgccctt ctcgtgggct gtgcaggcat tggcattggt ttctatggta acagcgagac
      421 cagtgatggg gtgtcccagc tcagctcagc actgcagcat gccaaccaca cgctcagcac
      481 cattgatgac ttggtgctgg aaacggtaga gaggctgggt gaggctgtga ggacagagct
      541 gaccaccctg gaggaagtgt tgtcagaacg cgtggagctg gtggctgcca cccggggagc
      601 cagaaggcag gctgaggcag cagctcagca cctgcaaggc ctagccttct ggcagggagt
      661 gtccctgagc ccagtacagg tggctgagga tgtgactttc gtggaggagt acaggtggct
      721 ggcctatgtc ctcctgctgc tcttggtgct tctggtttgt ctcttcaccc tcctgggcct
      781 ggccaagcag agcaagtggc tggtggttgt gatgaccgcc atgagtctcc tggtgcttgt
      841 cctgagctgg ggttctatgg gcctagaggc tgccacagct gtgggtctca gtgacttctg
      901 ctccaaccca gacacctatg tgctgaactt gacccaggag gagacaggaa tcagttcaga
      961 catcctcaac tattatttcc tgtgcaacca ggcggtctcc aaccccttcc aacagaggct
     1021 gactctgtcc cagcgtgctc tagccagcat ccactctcag ctgcaaggcc tggagcggga
     1081 agctagccct caatttcctg ctgcacagaa gcccttgtta tccttggagg agacgctgaa
     1141 tgtgacagaa agaagcttcc accagttggt ggcactgctg cactgccgca gtctgcacaa
     1201 ggactatggc tcagcactcc gaggcctgtg tgaagatgcc ctagagggcc tgctgttcct
     1261 gatgctcttt tctctcctgt ctgccggggc cctagccacc actctttgca gcctgccccg
     1321 tgcctgggct ctcttcccac ccaggaatcc aagcgctttg tgcagtggca gtcttccatc
     1381 tgagcccccc tgccagtgtg gcctgcctct cctctttggc tcagcactgc tttgcttctg
     1441 aaagtcacgt gtgaatcctg acaaggggga agaagcagat cccagaagag agtaagccta
     1501 acactaaatt aaacatgcgt gcatccacag gaagagtcaa ccttccagtc acgtggaatg
     1561 ttcaaagcct gctgggatta ggaacggtgt ggaatcgaat caacttgctt cctagcagct
     1621 catatcctac acaagaacgt cagaaaacta acgcttgttt caggataggg acagaaatct
     1681 tcagagagaa gtagaatatt tgctcgtaat gctaccacgg tgatgtaaag ggagaaggtt
     1741 taaggaagat aatataaatc cagacaggaa aagatgaggc aatcatcaag ttgtcaagta
     1801 aaaacaaaca tggcagagtc aaaagggaaa tttattgtct ggggaacaat tcctatgtag
     1861 ttcttatttg ttaaaaaaaa aaaaagtagc acacatgaca aaggaaaaca ttgttgttaa
     1921 tagataaaca taattcaaaa agcttctatt atctaacaaa aaacagacca actcaattta
     1981 gtaataagta actgagatga acgtacaagg aaacaaaatc cccaagacaa aggataaaac
     2041 tggggatttt tggttttcat tttggttttt ggttttttga gacaggcttt ctttgtaata
     2101 gacctgggtg tcctggaact ctttgtagac caggctggcc ttgacctcac agagaacagc
     2161 ctgcctctgc ctccctagta ctgagattaa agcatgtatc accatatcac cagctaaaat
     2221 gttcaagttc taatgattag caaacacgat gtgctacttt cccctttcta gtacctactt
     2281 gttgtggact ttaaagtggg gtgttggctg gtgctagtct ggaggctcag ggaaaaagtt
     2341 ctctgaatat gctgctcaga ggcggtgaat caccagctat gtgaaaataa taattaaaac
     2401 aaacaaacaa aacaaaaccc tgctcacatc tcttaacctg gtaatccttt ggggcacaag
     2461 cttccagtaa gagatgaaca ggcaaccctt ggctcagtta aaccctggag acagaaatgt
     2521 tcacaaaagg aagaacagta atgtagagca ggatcctcaa gttcacagtg gcaagtgggg
     2581 tacagaggca ccaggggtat ccctggccct gtgctggttg gaagcctctg ggtcctagac
     2641 ctggcaccac tatgttaatg tggacaagtt atctgactgg ttgaacctca gttgaatggt
     2701 gaagcaaatg ggtatcataa atccagaaaa cagctcttga catgataggt aataagcagg
     2761 ataaatgcag catgatgttc tgggttacat tctggtgcac agaaaacatt agtaggaaaa
     2821 gtacccactt ctaaagtctg cggcttagtt cagagtatta aagcaatgtc aatttcttac
     2881 ttttaacaaa taaaccatgg tgaattcgag gtgtggaatc tagcaatagg ggaaactggg
     2941 cagtgtgctc aattcctgta ttacctttgc aatttttatt tctgtaaact taaatttatt
     3001 ctaaaataaa agttcattat aaaaagga
//
LOCUS       NM_001106239             706 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12),
            transcript variant 1, mRNA.
ACCESSION   NM_001106239 XM_001078443 XM_214890
VERSION     NM_001106239.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 706)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 706)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 706)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 706)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001106239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW917069.1, SRR22399489.639410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                JAXUCZ010000001.1  93156288-93156306   c
            20-87               JAXUCZ010000001.1  93155999-93156066   c
            88-706              JAXUCZ010000001.1  93153424-93154042   c
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..706
                     /gene="Mrps12"
                     /note="mitochondrial ribosomal protein S12"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
     exon            1..19
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     exon            20..87
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..458
                     /gene="Mrps12"
                     /note="isoform 1 is encoded by transcript variant 1; 28S
                     ribosomal protein S12, mitochondrial; small ribosomal
                     subunit protein uS12m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12m isoform 1"
                     /protein_id="NP_001099709.1"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
                     /translation="MSWPGLLHGLTTSLSRGLALAPQLWATRSMATLNQMHRLGRPKE
                     PPKRLGPTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTL
                     QEHHVVLVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK"
     misc_feature    132..452
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    132..452
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    order(135..140,144..149,156..161)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    order(135..140,144..149,156..161)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    135..137
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    135..137
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    order(159..167,198..200,204..209,213..215,258..263,
                     267..275,294..296,318..320,327..332,369..374,384..389,
                     450..452)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(159..167,198..200,204..209,213..215,258..263,
                     267..275,294..296,318..320,327..332,369..374,384..389,
                     450..452)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(249..254,384..386)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(249..254,384..386)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    252..257
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    252..257
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(255..272,330..356)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     misc_feature    order(255..272,330..356)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     exon            88..706
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgaccct gctagtttgg gacgcagcct gcggcgagat gtcctggccc ggccttctcc
       61 atggcctcac cacgtccctc agtcgtggcc tagccctagc tccccagctc tgggccaccc
      121 gttccatggc caccctgaac cagatgcacc gcttaggccg cccgaaggaa ccccctaagc
      181 gtctgggccc cacggagggc cggccccagc tgaagggtgt ggtgttgcgc acatttatca
      241 ggaagccgaa gaagcccaac tccgccaacc ggaagtgctg ccgagtacgc ctcagcaccg
      301 gcaaagaggc tgtctgcttc atccccggcg agggccacac cctgcaggag caccacgtgg
      361 tcctcgtgga gggtggtcgc acccaggacc tgcctggggt taaactcaaa gttgtgaggg
      421 gcaagtatga ctgcggccac gtgcagaaga agaaatgacc ataattcaca gtgatctgct
      481 actggatcct tggaaacggg ttctttctgc tccaggggca gcttttcttg ggttcaaatc
      541 ttactctgac tcagcaagat gctattaacc tgcaagattt ctgaaggtga attggaagga
      601 ggaactcttg tgcccactcc cttgacttcc atgttcagtg tctgcaggtt gacctcatgc
      661 gctgggatgg gggttgtaat aaacatatct tcaggttgtg atgtca
//
LOCUS       NM_001438253            3151 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 3, mRNA.
ACCESSION   NM_001438253 XM_063282713
VERSION     NM_001438253.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282713.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1841170.1,
                                           SRR26643289.429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-593             JAXUCZ010000001.1  36702233-36702611
            594-719             JAXUCZ010000001.1  36703970-36704095
            720-873             JAXUCZ010000001.1  36705450-36705603
            874-962             JAXUCZ010000001.1  36706668-36706756
            963-1143            JAXUCZ010000001.1  36707831-36708011
            1144-1186           JAXUCZ010000001.1  36709666-36709708
            1187-1373           JAXUCZ010000001.1  36722626-36722812
            1374-1492           JAXUCZ010000001.1  36723647-36723765
            1493-1585           JAXUCZ010000001.1  36724215-36724307
            1586-1771           JAXUCZ010000001.1  36724407-36724592
            1772-3151           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3151
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    150..152
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     exon            215..593
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1916
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 3 is encoded by transcript variant 3;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 3"
                     /protein_id="NP_001425182.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSE
                     LQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQ
                     ASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSG
                     SEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAV
                     PKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPP
                     LNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLAT
                     LVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFV
                     GFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSR
                     DAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEII
                     SKEAGVDKLEAMKTLATLKQEKRYLQDIWS"
     misc_feature    645..1910
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    645..1910
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1167..1178,1221..1226,1275..1286,1389..1391,
                     1908..1910)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1167..1178,1221..1226,1275..1286,1389..1391,
                     1908..1910)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1167..1169,1173..1178)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1167..1169,1173..1178)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1176..1178,1767..1769,1902..1904,1908..1910)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1176..1178,1767..1769,1902..1904,1908..1910)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1227..1238,1449..1451,1455..1457,1554..1559,
                     1644..1649,1689..1691,1695..1697,1785..1787)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1227..1238,1449..1451,1455..1457,1554..1559,
                     1644..1649,1689..1691,1695..1697,1785..1787)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1275..1277,1284..1286,1293..1295)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1275..1277,1284..1286,1293..1295)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1440..1442,1452..1463,1467..1469)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1440..1442,1452..1463,1467..1469)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            594..719
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            720..873
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            874..962
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1143
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1186
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1373
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1492
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1585
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1771
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..3151
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtttaga gctcgtggta gaaccatgga
      241 ttgatggact ctggcctgct ctcacaaagc actttaagtc actcggagga caagaagaca
      301 tgagtgacag tgacacactc gcacaggcat cagatgcccc cttgagtatg gccatgaagc
      361 cagagttgtt gcacatccag tcacaagttg aacttctaag tttagaagac gtggggaaaa
      421 gggattctga gcttcaggaa caaaatgaga ccaacaagaa tcagccaagt cggatcgaag
      481 actttgactc ttcgcttgtt aactcggttc ccccactctc acagagctct ctaagtattc
      541 ctgctgtgtc cccagaatat ttggaggtct atcttcagga gtctcttggc caggatgaaa
      601 accaagcatc tgtgccacca tcagtcgatc caatttttca agttccaatt tcaaaagctg
      661 ttgagctgac tacaaacgat gccataaaga ccactctgct gttggaattg gacatctcaa
      721 aagtagagtt ttcccatcaa cctggagatt ccttcaatgt gatctgtcca aacagtggtt
      781 ctgaagtaga agacttgctg caaaggctgc agctggctga caaacaagca caccgggtca
      841 tcctgaaaat taagatggac accaagaaga aaggagcttc tctgccccag catgtgcctg
      901 aggggagttc tctccagttc atcttcacct ggtgtcttga aatacgagca gttcctaaaa
      961 aggctttttt gagggccctt tcggattaca ccagcgatgc cactgaaaag cggaggcttc
     1021 aggagctctg cagtaagcag ggagcagctg attacaaccg cttcatccga gatgccagtg
     1081 tctgcctgct agacctcctg cttaccttcc catcctgcca gcctccgctc aacctcctgc
     1141 tggagcacct tcctaaactc cagcctcgac catactcgtg cgcaagctcc agcttactcc
     1201 atccagacaa gcttcacttt gtgtttaaca tcgtagagct tccgtcgaac accactgcag
     1261 cctcactgcg gaagggagtg tgcacaggct ggctagccac attggttgct ccatttcttc
     1321 agccaaacac agaagttttg actgcagacc atagtgatgc tctggctcct gagatactta
     1381 tctctcctcg ggcaacaaat tccttccact taccagatga cctgtcggcc cccatcataa
     1441 tggtgggtcc aggaactggt gtagccccct ttgttggctt cctgcagcac agagaaaaac
     1501 tccaagaaca acacccagac ggaaactttg gagcaatgtg gctgtttttt ggctgcagac
     1561 ataaggacag agactatttg ttcagggagg agctcaggca tttcctcaag actggggtct
     1621 tgactcacct gaaggtctca ttctcaagag atgctgcgcc tgaggaagag gaggaggccc
     1681 cagcaaagta tgtgcaagac aacctccagc atcacagcca gcaggtggcc aggaccctcc
     1741 ttcaggagaa tggctacatt tacgtgtgtg gagacgccaa gaatatggct aaggatgtac
     1801 acgacgccct tgtagaaatc ataagcaaag aagctggagt tgacaaacta gaagcaatga
     1861 agacactggc aaccttaaag caagaaaagc ggtatctgca ggatatctgg tcgtgaaact
     1921 agaagggagg tttcagtgtg cttgcttgct tgtttgtttt ttgaaatgcc aaaggacagt
     1981 tgtacagaag ataggttttg ggtatttctt ggcagaggct ttgtggggaa cagctcactt
     2041 acaggtacca ccgcctgata caatctcagg tttgtctccc actctgtgtc ccacccagca
     2101 ccccactgtg tggagcggag aggcagctct cagctggctc ccaaggagga cagatagtcg
     2161 tcaatggctc tgggcacatc gtggagagtt tgtggacatg ttctctttca atgaagtaca
     2221 ttcagaggat attcattctg atgatattta aattaataca gacatacaga gcatactttt
     2281 gcatgtttgc acttaattgt ggtttattat caaaattata tttctgataa aatattttaa
     2341 ttttgaggta atccttacaa aataagggtt tttatgctac tagaaatata ttttgaaata
     2401 caattgaaat tgtgctctgc cattttcatc atgttaactt ttagtgtcac agtcctacag
     2461 cttaggggca tttgcattcc cctgacaaag gcatgtgtgt acatctcagt aacatcatgc
     2521 cctgttctcc tggactctat tcatcaatgc tcctcactaa cagacttggt attccccaat
     2581 acctgactgt acttctgtga ttcagctcag agtaaagagc tccagttaga cttctaatac
     2641 caaattctct tgcaagtttc gaaaataaag catataaaag gattctgtgc cattgtgtgt
     2701 atggttgctg agacaaaact gggacaaagc aacttaatga gagatggtat ttctgctcac
     2761 agttccagta tgtggtccat ggtgctggtg aagtcatggt ggcagaagga gaagacaact
     2821 ggtcatgtta catccagtca gaaggaaacg acatgcatgc ctcactggct ttctcctttt
     2881 cacacacact gtctagaact ttcacacaca gaatgggtct gcctacatgt actgtgggtg
     2941 ttcacctcag cgtagtccag aggacctctc agcagtggtt tgtctccagt gaggccacag
     3001 ccatcacatg catgataaac tctccattca gtgtatagtt attgtcttgt ttaatagttc
     3061 aacatttaaa acacaactct gcctggtgag atgtcactaa gagactccct ggtcattata
     3121 agaattaaag atttgaaaaa ataatctcaa a
//
LOCUS       NM_001438266            4284 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 418 (Zfp418), transcript
            variant 2, mRNA.
ACCESSION   NM_001438266
VERSION     NM_001438266.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4284)
  AUTHORS   Singh,S.R., Meyer-Jens,M., Alizoti,E., Bacon,W.C., Davis,G.,
            Osinska,H., Gulick,J., Reischmann-Dusener,S., Orthey,E.,
            McLendon,P.M., Molkentin,J.D., Schlossarek,S., Robbins,J. and
            Carrier,L.
  TITLE     A high-throughput screening identifies ZNF418 as a novel regulator
            of the ubiquitin-proteasome system and autophagy-lysosomal pathway
  JOURNAL   Autophagy 17 (10), 3124-3139 (2021)
   PUBMED   33249983
REFERENCE   2  (bases 1 to 4284)
  AUTHORS   Pan,L., Sheng,M., Huang,Z., Zhu,Z., Xu,C., Teng,L., He,L., Gu,C.,
            Yi,C. and Li,J.
  TITLE     Zinc-finger protein 418 overexpression protects against cardiac
            hypertrophy and fibrosis
  JOURNAL   PLoS One 12 (10), e0186635 (2017)
   PUBMED   29065170
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.228664.1,
                                           SRR26360176.1957250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000001.1  75614540-75614743
            205-331             JAXUCZ010000001.1  75617889-75618015
            332-4284            JAXUCZ010000001.1  75623415-75627367
FEATURES             Location/Qualifiers
     source          1..4284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..4284
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="zinc finger protein 418"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
     exon            1..204
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream in-frame stop codon"
     misc_feature    109..111
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MKAKKTVGSSGSCVRAPALSTEP"
     CDS             178..2121
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 418 isoform 2"
                     /protein_id="NP_001425195.1"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
                     /translation="MAAVKHLAQGCVTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLEN
                     FTLISSLVYRYEAEAEEKTCAQSLSQTEAPQVRTPKQGQLRQKPHPSDICITVLKDIL
                     HLNDLPGQKPYLTEVCTKPQDHKHHRAKNWLKRDVDSLVKSCIFHVAGNPFICSKIGE
                     KFPAIWNLLQPKDIPNGEKQNKIKRGKAFHRDKNNSESDEYKKSSSPQHRLHEYPGVC
                     SAKGGFESNSCEQDLNKYSPAPFRMDQTENRPYECHVCGKWFGQKATLRIHQRRHTGE
                     KPYKCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWP
                     YECSDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYH
                     CEACGKSFSQSANLIKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECR
                     ECGKFFKQYFYLIEHRRIHTTTEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEEC
                     GKAFEYKSRLKRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKPYHCDQCGK
                     CFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSF
                     SQVSTLTRHQLLHTGEKPYKCSK"
     misc_feature    208..330
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    208..330
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    934..996
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    934..996
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(949..951,955..957,961..963,967..972,979..984,
                     991..993,1033..1035,1039..1041,1051..1056,1063..1068,
                     1075..1077,1117..1119,1123..1125,1129..1131,1135..1140,
                     1147..1152,1159..1161)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(949..951,955..957,961..963,967..972,979..984,
                     991..993,1033..1035,1039..1041,1051..1056,1063..1068,
                     1075..1077,1117..1119,1123..1125,1129..1131,1135..1140,
                     1147..1152,1159..1161)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1006..2079
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1006..2079
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1018..1080
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1018..1080
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1102..1164
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1102..1164
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1186..1248
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1186..1248
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1270..1332
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1270..1332
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1285..1287,1291..1293,1297..1299,1303..1308,
                     1315..1320,1327..1329,1369..1371,1375..1377,1387..1392,
                     1399..1404,1411..1413,1453..1455,1459..1461,1465..1467,
                     1471..1476,1483..1488,1495..1497)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1285..1287,1291..1293,1297..1299,1303..1308,
                     1315..1320,1327..1329,1369..1371,1375..1377,1387..1392,
                     1399..1404,1411..1413,1453..1455,1459..1461,1465..1467,
                     1471..1476,1483..1488,1495..1497)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1354..1416
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1354..1416
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1438..1500
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1438..1500
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1522..1584
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1522..1584
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1606..1668
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1606..1668
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1690..1752
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1690..1752
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1774..1836
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1774..1836
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1858..1920
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1858..1920
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1873..1875,1879..1881,1885..1887,1891..1896,
                     1903..1908,1915..1917,1957..1959,1963..1965,1975..1980,
                     1987..1992,1999..2001,2041..2043,2047..2049,2053..2055,
                     2059..2064,2071..2076,2083..2085)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1873..1875,1879..1881,1885..1887,1891..1896,
                     1903..1908,1915..1917,1957..1959,1963..1965,1975..1980,
                     1987..1992,1999..2001,2041..2043,2047..2049,2053..2055,
                     2059..2064,2071..2076,2083..2085)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1942..2004
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1942..2004
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2026..2088
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2026..2088
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            205..331
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            332..4284
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcgtc ctgtctttgg tttaacttcc catgggttgg tatttggagg attctgagct
       61 ttaggatcgc caaattatac tcaagttaag agagagagcc ggcgcaggat gaaggccaag
      121 aagaccgtag gcagcagcgg tagctgtgtc cgggcccctg cgttgtcaac agagccgatg
      181 gcggctgtga agcacctggc tcagggctgt gtaaccattg aggacgtgac tgtttacttc
      241 tcccaggaag agtggaagct cctggatgaa gctcagaggc tactgtatct tgatgtgatg
      301 ctggagaatt ttacccttat atcctcactg gtttatcggt atgaagcaga ggctgaagaa
      361 aaaacctgtg cacagagtct ttcacaaact gaagcaccac aagtcaggac tccgaagcaa
      421 ggtcaactca ggcagaagcc tcatccctct gacatctgta tcaccgtcct gaaagatatc
      481 ttgcatctga acgacctacc tgggcaaaag ccgtatttga ccgaagtgtg tacaaagccc
      541 caggaccata agcatcacag agccaagaat tggttaaaga gagacgtgga ctcccttgtg
      601 aagagctgta tattccatgt ggcagggaac cctttcatct gtagtaagat tggagagaaa
      661 ttcccagcta tatggaatct tctccaaccc aaggacatcc ccaacggtga gaaacaaaat
      721 aaaattaagc gtggaaaggc ttttcacagg gataaaaata attctgaatc agatgaatat
      781 aagaaatctt ccagccccca acacaggctt catgaatacc caggagtttg cagtgcaaag
      841 gggggttttg aatctaacag ttgtgagcaa gacttaaaca agtactcacc tgcaccattc
      901 cggatggacc agactgaaaa ccgaccatat gagtgtcatg tctgtggaaa atggtttggc
      961 cagaaagcca cacttagaat acaccagaga cgtcataccg gagaaaaacc atataagtgt
     1021 ggtgaatgtg gaaagtcttt ttgtcaaagc tctaacctaa gtgaacactg cagagttcat
     1081 agtggagaaa gaccttttga gtgtctggaa tgtgggaaag cctttgggtg ccattctagt
     1141 cttctgcggc accagagaac acacactgga gaatggccat atgaatgcag tgactgtggg
     1201 agactgttta gacagattgt cagcctgatt acacaccaga ggactcacac taccgagaag
     1261 ccttatgaat gtggacagtg tgagaagtct tttagtcaca aagccactct tactgtacat
     1321 cagagagttc acactgggga aaagccctat cactgtgaag cctgtgggaa atccttcagc
     1381 caaagtgcca accttattaa acactccaaa attcacactg gagaaaagcc ttatgagtgt
     1441 ggagaatgcg gtctatgctt tcgccagaga gctaccctca tgaaacacca gagaacccac
     1501 acgtcagaaa ggccttatga atgtagagaa tgtggtaagt tctttaaaca atacttctac
     1561 ctcattgaac accgtaggat tcacaccaca acagaatttt atgagtgtga acagtgcggg
     1621 aagtcttata cccaaaaagc cacccttatc agacaccaac gagtccacac aggagagagt
     1681 ccttataaat gtgaggagtg tggaaaagcc tttgaataca aatccagact taagcgacat
     1741 caaagaacgc acactggtga aaggccttat gagtgtgcca aatgtgggaa attcttcaga
     1801 gaaagctaca atcttgctga acaccagaaa attcacacta aagcaaagcc ttaccattgt
     1861 gatcagtgtg ggaagtgttt tagccggaga gctgacttgg ttaaacacca gagagttcac
     1921 actggtgaaa gaccttatac ttgtggtgaa tgtgggaaga ccttcagccg aactaccaac
     1981 cttgttcaac acagaagaat tcacactggg gaacggccat acgagtgtga ccagtgtggg
     2041 aaatctttta gccaggtgtc taccctcact cgacatcagc tacttcacac tggagaaaaa
     2101 ccgtataagt gtagcaaatg aaggaaagtc tagacagccc tctagcatct tctaacacca
     2161 aaagatagac catcacagct cccggaagcc aacccttgaa agcaccctca ggcctccaag
     2221 gatattacat tgttcactgt aacaaactag agagcctcat agagttctag gtcatgtaat
     2281 ttgtaccaga gctagcctgc atgttctgga cagtctgtac cccttgccag agttaaagag
     2341 ctgtcataat gtctcataga cactgtctct tctctagcac cttgcactga gtgcatatgc
     2401 accaccacca ccccacccca cccttgcaac atgccgtact ctccccttcc ctaatagaag
     2461 cctcaacttc ctgtgccttg caaatgacct tgatcccttt ttctcactgg atatttctgg
     2521 gtctgtattt tgcctaaagg aacatggtct gggatgagtg ggaggctcca gcaaggatta
     2581 tcttctcaag tctgtctcac atgattcgtg tgactgttta catactccaa atcactagcc
     2641 aggaacttcc tgtcaggatg tgcaataata aaagacctta tttttttttc ccccatgtac
     2701 ttttaatcaa gagtttctat tcacagactt aggcagccaa aatactatga taggtcctgt
     2761 ttttgttttg tttaattatt tttatttaca ttcaagccgt tgccttccat cacctctccc
     2821 tcaagtcttc atccccctcc tttttctcct tgccttcaag agggtgcccc tgccaccagg
     2881 cctccccctt ccctggtgcc tcaagtctct caaggcgtat cttctcccac tgaggccaga
     2941 ccacgcagtc ctctgatata tatgtgctag gggttgcctg tttggtaggc tctgtttata
     3001 tagaaattgt aacagtgttt gggtttttta tttaatattt atttattgaa tgtacatgtg
     3061 tgctctgtct tcatgcacac cagaagaggg aatcaattct gagccatcat gtggttgctg
     3121 gaattgaact caggccctcc agaagatcag ccagtgctct taacatctga gccatctctc
     3181 cttccctgga acaggtcttg aggctgcacc attcatgcct cagcatgggt aatgggaaag
     3241 agtagctctc gtttatgttg ctttccaaaa cctttagtgg aacaaagcag ggtgttcagt
     3301 cctagctttg tgcttttttt gtttgttgtt gggaggaagg tgttttgttt ttagactacc
     3361 ctgaggtcac ttgttggaac tgcaacattc agtgctctta gaatagcttt aacttatccc
     3421 atcattccca catggtctga cctgattatg cccaagattg tcgaagagaa acttttctat
     3481 gaggttcata gacaccaagt ccataattcc aaatgtcact tgaaaaatta ggagaaccaa
     3541 ataggaacaa taacgggtag attaatacaa gctttaaggg tcggagaggt ggctcagcag
     3601 ttaagagcac ccgactactc ttccagaggt cctgagttca attcccagca accacatggt
     3661 ggctcacaac catctgtaaa gagatccgat gtcctcttct gttgtatctg aagacagctc
     3721 agtgtactta tttataataa atgaataaat cttttttaaa aaatacaggt tttgataatt
     3781 gaaaggtggg gttttatatg agaacattac ctggggattg attactctag agaccacaga
     3841 tattgcattc tggaaaataa tttgcctgta tcttgtgtcc tgaaatctta actgagtctg
     3901 aattcatgct gtaacttata gccagattta cagtgagcaa catcagcaaa acgccaatca
     3961 gaaagattca aaagcaggca gttttgccag gaacagaatg tattgggaga tacaaagaag
     4021 ccatagttac taatgggatc acactgttaa aagaaactaa gtactttgta ctaggggtgt
     4081 agaaaaataa taaagatacc ttgatggctc agcttctctt ccagagatcc tgagttccat
     4141 tcccaggaac tgcatggtgg ctcacaagca tttattaagg aatctgatgc cctcttctgg
     4201 tatgtaggtg tatgtgcaga tagcactcac ttataaataa ataaataaat aaataaataa
     4261 ataattttta atttgtttta aaaa
//
LOCUS       NM_001438245            1944 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus activating transcription factor 5 (Atf5),
            transcript variant 2, mRNA.
ACCESSION   NM_001438245
VERSION     NM_001438245.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Madarampalli,B., Yuan,Y., Liu,D., Lengel,K., Xu,Y., Li,G., Yang,J.,
            Liu,X., Lu,Z. and Liu,D.X.
  TITLE     ATF5 Connects the Pericentriolar Materials to the Proximal End of
            the Mother Centriole
  JOURNAL   Cell 162 (3), 580-592 (2015)
   PUBMED   26213385
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Zhang,Z.Y., Li,S.Z., Zhang,H.H., Wu,Q.R., Gong,J., Liang,T.,
            Gao,L., Xing,N.N., Liu,W.B., Du,R.L. and Zhang,X.D.
  TITLE     Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates
            the interleukin-1beta-stimulated C/EBP signaling pathway
  JOURNAL   Mol Cell Biol 35 (5), 778-788 (2015)
   PUBMED   25512613
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Zhao,Y., Zhang,Y.D., Zhang,Y.Y., Qian,S.W., Zhang,Z.C., Li,S.F.,
            Guo,L., Liu,Y., Wen,B., Lei,Q.Y., Tang,Q.Q. and Li,X.
  TITLE     p300-dependent acetylation of activating transcription factor 5
            enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1
            differentiation
  JOURNAL   Mol Cell Biol 34 (3), 315-324 (2014)
   PUBMED   24216764
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Wang,S.Z., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Transcription factor ATF5 is required for terminal differentiation
            and survival of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), 18589-18594 (2012)
   PUBMED   23090999
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Liu,X., Liu,D., Qian,D., Dai,J., An,Y., Jiang,S., Stanley,B.,
            Yang,J., Wang,B., Liu,X. and Liu,D.X.
  TITLE     Nucleophosmin (NPM1/B23) interacts with activating transcription
            factor 5 (ATF5) protein and promotes proteasome- and
            caspase-dependent ATF5 degradation in hepatocellular carcinoma
            cells
  JOURNAL   J Biol Chem 287 (23), 19599-19609 (2012)
   PUBMED   22528486
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Forgacs,E., Gupta,S.K., Kerry,J.A. and Semmes,O.J.
  TITLE     The bZIP transcription factor ATFx binds human T-cell leukemia
            virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal
            repeat-mediated transcription
  JOURNAL   J Virol 79 (11), 6932-6939 (2005)
   PUBMED   15890932
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Angelastro,J.M., Mason,J.L., Ignatova,T.N., Kukekov,V.G.,
            Stengren,G.B., Goldman,J.E. and Greene,L.A.
  TITLE     Downregulation of activating transcription factor 5 is required for
            differentiation of neural progenitor cells into astrocytes
  JOURNAL   J Neurosci 25 (15), 3889-3899 (2005)
   PUBMED   15829641
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Angelastro,J.M., Ignatova,T.N., Kukekov,V.G., Steindler,D.A.,
            Stengren,G.B., Mendelsohn,C. and Greene,L.A.
  TITLE     Regulated expression of ATF5 is required for the progression of
            neural progenitor cells to neurons
  JOURNAL   J Neurosci 23 (11), 4590-4600 (2003)
   PUBMED   12805299
  REMARK    GeneRIF: ATF5 blocks the differentiation of neuroprogenitor cells
            into neurons and must be downregulated to permit this process to
            occur.
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Persengiev,S.P., Devireddy,L.R. and Green,M.R.
  TITLE     Inhibition of apoptosis by ATFx: a novel role for a member of the
            ATF/CREB family of mammalian bZIP transcription factors
  JOURNAL   Genes Dev 16 (14), 1806-1814 (2002)
   PUBMED   12130540
REFERENCE   10 (bases 1 to 1944)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1381.1,
                                           SRR26643297.1627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000001.1  104436344-104436563 c
            221-395             JAXUCZ010000001.1  104436005-104436179 c
            396-689             JAXUCZ010000001.1  104434601-104434894 c
            690-1944            JAXUCZ010000001.1  104432094-104433348 c
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1944
                     /gene="Atf5"
                     /note="activating transcription factor 5"
                     /db_xref="GeneID:282840"
                     /db_xref="RGD:628902"
     exon            1..220
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
     exon            221..395
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
     exon            396..689
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    434..436
                     /gene="Atf5"
                     /note="upstream in-frame stop codon"
     CDS             512..1357
                     /gene="Atf5"
                     /note="cAMP-dependent transcription factor ATF-5;
                     transcription factor ATFx"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-5"
                     /protein_id="NP_001425174.1"
                     /db_xref="GeneID:282840"
                     /db_xref="RGD:628902"
                     /translation="MSLLATLGLELDRALLPASGLGWLVDYGKLPLAPAPLGPYEVLG
                     GALEGGLPGGGEPLAGDGFSDWMTERVDFTALLPLEAPLPPGTLPPPSPAPPDLEAMA
                     SLLKKELEQMEDFFLDAPLLPPPSPPPPPPPAPSLPLPLPLPTFDLPQPPTLDTLDLL
                     AVYCRSEAGPGDSGLTTLPVPQQPPPLAPLPSPSRPAPYPSPASTRGDRKQKKRDQNK
                     SAALRYRQRKRAEGEALEGECQGLEARNRELRERAESVEREIQYVKDLLIEVYKARSQ
                     RTRSA"
     misc_feature    512..574
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Required for protein stabilization induced by
                     IL1B. /evidence=ECO:0000250|UniProtKB:Q9Y2D1"
     misc_feature    596..598
                     /gene="Atf5"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000269|PubMed:21791614; propagated from
                     UniProtKB/Swiss-Prot (Q6P788.1); acetylation site"
     misc_feature    863..967
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    866..1159
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Interaction with PTP4A1.
                     /evidence=ECO:0000250|UniProtKB:O70191"
     misc_feature    1007..1219
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1133..1321
                     /gene="Atf5"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-4 (ATF-4) and similar proteins: a
                     DNA-binding and dimerization domain; Region: bZIP_ATF4;
                     cd14692"
                     /db_xref="CDD:269840"
     misc_feature    1133..1321
                     /gene="Atf5"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-4 (ATF-4) and similar proteins: a
                     DNA-binding and dimerization domain; Region: bZIP_ATF4;
                     cd14692"
                     /db_xref="CDD:269840"
     misc_feature    1136..1198
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     misc_feature    1139..1318
                     /gene="Atf5"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269840"
     misc_feature    1139..1318
                     /gene="Atf5"
                     /note="coiled coil [structural motif]; Region: coiled
                     coil"
                     /db_xref="CDD:269840"
     misc_feature    order(1148..1153,1157..1165,1169..1186,1190..1198)
                     /gene="Atf5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269840"
     misc_feature    order(1148..1153,1157..1165,1169..1186,1190..1198)
                     /gene="Atf5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269840"
     misc_feature    order(1205..1207,1214..1216,1223..1228,1235..1240,
                     1244..1249,1256..1261,1265..1270,1277..1279,1286..1291,
                     1298..1303,1307..1312)
                     /gene="Atf5"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269840"
     misc_feature    order(1205..1207,1214..1216,1223..1228,1235..1240,
                     1244..1249,1256..1261,1265..1270,1277..1279,1286..1291,
                     1298..1303,1307..1312)
                     /gene="Atf5"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:269840"
     misc_feature    1214..1258
                     /gene="Atf5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P788.1);
                     Region: Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
     misc_feature    1274..1276
                     /gene="Atf5"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2D1; propagated from
                     UniProtKB/Swiss-Prot (Q6P788.1); phosphorylation site"
     exon            690..1944
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcccttga actcgtctat gaagcctaag ctagcttgaa ctcgccattc cgcgatgagc
       61 ttaacccacg aggtctctcg gagcgacatc ggttttaggg actggtggca aatttgtgaa
      121 gcagggatag ataacgggat gagctggtta cgggtgtaag agagatcgaa taggatccaa
      181 ccgatacagg aaacagagtc cgggccccca gcctgaagca tctcccttaa cgctcctgcc
      241 acgccgcctc cgcccgtgca atggctctgt agccgcgatc tcgtcgtgtc ccccgccccg
      301 tttccgcgct caccgcgact tcactctctg ctcacaccga ctcttcaact gaggccgccg
      361 ccgccgttgc ctcctctcct tttcgcagcc atggagccct ccaccttcgc cttggtgcct
      421 gtcttcaccc agctgaacaa tcttccacgc tgcctcccag ttgttggtgc agcctccatt
      481 gccatcgcag ccctgcacct gtgcctcagc catgtcactc ctggcgaccc tgggactgga
      541 gctggacagg gccctgctcc cagctagcgg gctgggctgg ctcgtagact atgggaaact
      601 ccccctggcc cctgcccccc tgggccccta tgaggtcctt gggggtgccc tggagggcgg
      661 gcttccaggg gggggagagc ccctggcagg tgacggcttc tctgattgga tgaccgagcg
      721 ggtggacttc acagccctcc ttcctctgga ggcccctctg cccccaggca ctctcccccc
      781 accctcccct gccccccctg acctggaagc catggcatcc ctactcaaga aggagctaga
      841 acagatggaa gacttcttcc ttgatgcccc actccttcca ccgccctccc cacctccacc
      901 cccaccccca gcaccctctc tgcccctgcc cttacccttg cccacctttg atctcccgca
      961 gcctcctacc ctggataccc tggacttgct agctgtttac tgccgcagtg aggctgggcc
     1021 aggggattca ggcttgacaa ccctgcctgt cccccagcag cctcctcctc tggcccctct
     1081 gccttcaccc tcccgaccag ccccctatcc tagtcctgcc agcacccgag gggaccgcaa
     1141 gcaaaagaag agagaccaga ataagtcagc tgctctcagg taccgccaga ggaagcgggc
     1201 agagggcgag gccctggagg gcgagtgcca agggctagag gcgcggaatc gggagctgag
     1261 ggagagggca gagtcagtgg aacgggagat ccagtatgtg aaggatctgc taattgaggt
     1321 gtataaggca cgaagccaga ggacccgcag tgcctagggt acaggaggag gcagttctgg
     1381 tgtacctgtg cctccagctt caccctgtcc ctccatttca cttccctgtg catccgtgtc
     1441 taggtctccc ctctgcctat ccccattatg ggttatttgg catagtcagt ttctgtaccc
     1501 cttcagtgca actgagaaac caaggccctc agggaatcag aggagccagc ctgatccctg
     1561 gtctctggag tcttaaaaca agtgtgtttt tgcaggtagt cctagttggg tgtcgggggg
     1621 aggctgccag gcctggcatg gacattaggc aggaagccac tctggatgat tgtgcacatg
     1681 agaacctagt cagggaggga gggttttaag gagaggactt agaatacaag tgagaagcca
     1741 gccgaggaaa gggaaccaag tcctcagaat agaaggctat actggcctag ggacaggaag
     1801 gggtggctgt agttggtaac tagggtgtca ttttagctct gtgagagaat cagtgttttg
     1861 tgaaggtgtg ggggaagggt tgcatctggt gggggctgat cctccagggg ttgtgggctc
     1921 aaataaaatg cagactttcc tgtg
//
LOCUS       NM_001438254            3305 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 4, mRNA.
ACCESSION   NM_001438254
VERSION     NM_001438254.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3305)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3305)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3305)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.570.1, SRR26643297.411.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-368             JAXUCZ010000001.1  36697967-36698120
            369-747             JAXUCZ010000001.1  36702233-36702611
            748-873             JAXUCZ010000001.1  36703970-36704095
            874-1027            JAXUCZ010000001.1  36705450-36705603
            1028-1116           JAXUCZ010000001.1  36706668-36706756
            1117-1297           JAXUCZ010000001.1  36707831-36708011
            1298-1340           JAXUCZ010000001.1  36709666-36709708
            1341-1527           JAXUCZ010000001.1  36722626-36722812
            1528-1646           JAXUCZ010000001.1  36723647-36723765
            1647-1739           JAXUCZ010000001.1  36724215-36724307
            1740-1925           JAXUCZ010000001.1  36724407-36724592
            1926-3305           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3305
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            215..368
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    217..219
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     exon            369..747
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..2070
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 3 is encoded by transcript variant 4;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 3"
                     /protein_id="NP_001425183.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSE
                     LQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQ
                     ASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSG
                     SEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAV
                     PKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPP
                     LNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLAT
                     LVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFV
                     GFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSR
                     DAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEII
                     SKEAGVDKLEAMKTLATLKQEKRYLQDIWS"
     misc_feature    799..2064
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    799..2064
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1321..1332,1375..1380,1429..1440,1543..1545,
                     2062..2064)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1321..1332,1375..1380,1429..1440,1543..1545,
                     2062..2064)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1321..1323,1327..1332)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1321..1323,1327..1332)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1330..1332,1921..1923,2056..2058,2062..2064)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1330..1332,1921..1923,2056..2058,2062..2064)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1381..1392,1603..1605,1609..1611,1708..1713,
                     1798..1803,1843..1845,1849..1851,1939..1941)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1381..1392,1603..1605,1609..1611,1708..1713,
                     1798..1803,1843..1845,1849..1851,1939..1941)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1429..1431,1438..1440,1447..1449)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1429..1431,1438..1440,1447..1449)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1594..1596,1606..1617,1621..1623)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1594..1596,1606..1617,1621..1623)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            748..873
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1027
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1116
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1297
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1340
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1527
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1646
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1739
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1925
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..3305
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtatgat ctgaaaaccg aaactggccc
      241 tctggtgatg gttgtatcta ccacgggtac tggagaccca cccgacacag cccgcaagtt
      301 tgtgaaagaa atacacaaca agacactacc cacagacttc tttgctcacc tgtggtatgg
      361 attattggtt tagagctcgt ggtagaacca tggattgatg gactctggcc tgctctcaca
      421 aagcacttta agtcactcgg aggacaagaa gacatgagtg acagtgacac actcgcacag
      481 gcatcagatg cccccttgag tatggccatg aagccagagt tgttgcacat ccagtcacaa
      541 gttgaacttc taagtttaga agacgtgggg aaaagggatt ctgagcttca ggaacaaaat
      601 gagaccaaca agaatcagcc aagtcggatc gaagactttg actcttcgct tgttaactcg
      661 gttcccccac tctcacagag ctctctaagt attcctgctg tgtccccaga atatttggag
      721 gtctatcttc aggagtctct tggccaggat gaaaaccaag catctgtgcc accatcagtc
      781 gatccaattt ttcaagttcc aatttcaaaa gctgttgagc tgactacaaa cgatgccata
      841 aagaccactc tgctgttgga attggacatc tcaaaagtag agttttccca tcaacctgga
      901 gattccttca atgtgatctg tccaaacagt ggttctgaag tagaagactt gctgcaaagg
      961 ctgcagctgg ctgacaaaca agcacaccgg gtcatcctga aaattaagat ggacaccaag
     1021 aagaaaggag cttctctgcc ccagcatgtg cctgagggga gttctctcca gttcatcttc
     1081 acctggtgtc ttgaaatacg agcagttcct aaaaaggctt ttttgagggc cctttcggat
     1141 tacaccagcg atgccactga aaagcggagg cttcaggagc tctgcagtaa gcagggagca
     1201 gctgattaca accgcttcat ccgagatgcc agtgtctgcc tgctagacct cctgcttacc
     1261 ttcccatcct gccagcctcc gctcaacctc ctgctggagc accttcctaa actccagcct
     1321 cgaccatact cgtgcgcaag ctccagctta ctccatccag acaagcttca ctttgtgttt
     1381 aacatcgtag agcttccgtc gaacaccact gcagcctcac tgcggaaggg agtgtgcaca
     1441 ggctggctag ccacattggt tgctccattt cttcagccaa acacagaagt tttgactgca
     1501 gaccatagtg atgctctggc tcctgagata cttatctctc ctcgggcaac aaattccttc
     1561 cacttaccag atgacctgtc ggcccccatc ataatggtgg gtccaggaac tggtgtagcc
     1621 ccctttgttg gcttcctgca gcacagagaa aaactccaag aacaacaccc agacggaaac
     1681 tttggagcaa tgtggctgtt ttttggctgc agacataagg acagagacta tttgttcagg
     1741 gaggagctca ggcatttcct caagactggg gtcttgactc acctgaaggt ctcattctca
     1801 agagatgctg cgcctgagga agaggaggag gccccagcaa agtatgtgca agacaacctc
     1861 cagcatcaca gccagcaggt ggccaggacc ctccttcagg agaatggcta catttacgtg
     1921 tgtggagacg ccaagaatat ggctaaggat gtacacgacg cccttgtaga aatcataagc
     1981 aaagaagctg gagttgacaa actagaagca atgaagacac tggcaacctt aaagcaagaa
     2041 aagcggtatc tgcaggatat ctggtcgtga aactagaagg gaggtttcag tgtgcttgct
     2101 tgcttgtttg ttttttgaaa tgccaaagga cagttgtaca gaagataggt tttgggtatt
     2161 tcttggcaga ggctttgtgg ggaacagctc acttacaggt accaccgcct gatacaatct
     2221 caggtttgtc tcccactctg tgtcccaccc agcaccccac tgtgtggagc ggagaggcag
     2281 ctctcagctg gctcccaagg aggacagata gtcgtcaatg gctctgggca catcgtggag
     2341 agtttgtgga catgttctct ttcaatgaag tacattcaga ggatattcat tctgatgata
     2401 tttaaattaa tacagacata cagagcatac ttttgcatgt ttgcacttaa ttgtggttta
     2461 ttatcaaaat tatatttctg ataaaatatt ttaattttga ggtaatcctt acaaaataag
     2521 ggtttttatg ctactagaaa tatattttga aatacaattg aaattgtgct ctgccatttt
     2581 catcatgtta acttttagtg tcacagtcct acagcttagg ggcatttgca ttcccctgac
     2641 aaaggcatgt gtgtacatct cagtaacatc atgccctgtt ctcctggact ctattcatca
     2701 atgctcctca ctaacagact tggtattccc caatacctga ctgtacttct gtgattcagc
     2761 tcagagtaaa gagctccagt tagacttcta ataccaaatt ctcttgcaag tttcgaaaat
     2821 aaagcatata aaaggattct gtgccattgt gtgtatggtt gctgagacaa aactgggaca
     2881 aagcaactta atgagagatg gtatttctgc tcacagttcc agtatgtggt ccatggtgct
     2941 ggtgaagtca tggtggcaga aggagaagac aactggtcat gttacatcca gtcagaagga
     3001 aacgacatgc atgcctcact ggctttctcc ttttcacaca cactgtctag aactttcaca
     3061 cacagaatgg gtctgcctac atgtactgtg ggtgttcacc tcagcgtagt ccagaggacc
     3121 tctcagcagt ggtttgtctc cagtgaggcc acagccatca catgcatgat aaactctcca
     3181 ttcagtgtat agttattgtc ttgtttaata gttcaacatt taaaacacaa ctctgcctgg
     3241 tgagatgtca ctaagagact ccctggtcat tataagaatt aaagatttga aaaaataatc
     3301 tcaaa
//
LOCUS       NM_001438324            1383 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus StAR-related lipid transfer domain containing 10
            (Stard10), transcript variant 1, mRNA.
ACCESSION   NM_001438324
VERSION     NM_001438324.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Ito,M., Yamanashi,Y., Toyoda,Y., Izumi-Nakaseko,H., Oda,S.,
            Sugiyama,A., Kuroda,M., Suzuki,H., Takada,T. and Adachi-Akahane,S.
  TITLE     Disruption of Stard10 gene alters the PPARalpha-mediated bile acid
            homeostasis
  JOURNAL   Biochim Biophys Acta 1831 (2), 459-468 (2013)
   PUBMED   23200860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1488085.1, DN948339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000001.1  165134407-165134635
            230-549             JAXUCZ010000001.1  165134991-165135310
            550-697             JAXUCZ010000001.1  165155405-165155552
            698-801             JAXUCZ010000001.1  165156043-165156146
            802-919             JAXUCZ010000001.1  165156758-165156875
            920-972             JAXUCZ010000001.1  165158462-165158514
            973-1383            JAXUCZ010000001.1  165158724-165159134
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1383
                     /gene="Stard10"
                     /note="StAR-related lipid transfer domain containing 10"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
     exon            1..229
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            230..549
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1215
                     /gene="Stard10"
                     /note="isoform 1 is encoded by transcript variant 1; START
                     domain containing 10; PCTP-like protein; StAR-related
                     lipid transfer (START) domain containing 10; START
                     domain-containing protein 10"
                     /codon_start=1
                     /product="START domain-containing protein 10 isoform 1"
                     /protein_id="NP_001425253.1"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
                     /translation="MEKPAASTEPQGPRPALGRESVQVPDDQDFRSFRSECEAEVGWN
                     LTYSKAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIET
                     FDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKD
                     LVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKA
                     CIKYPEWKQKHQPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVTESREERA
                     GGAGEGSDDDTSLT"
     misc_feature    397..1065
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    397..1065
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    order(478..483,502..504,544..546,550..552,586..588,
                     598..600,616..618,625..630,634..639,694..696,700..711,
                     715..717,724..726,730..732,736..738,781..783,832..834,
                     838..849,853..855,889..891,895..897,901..903,907..909,
                     913..915,919..921,940..942,946..954,958..966,973..978,
                     985..987)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     misc_feature    order(478..483,502..504,544..546,550..552,586..588,
                     598..600,616..618,625..630,634..639,694..696,700..711,
                     715..717,724..726,730..732,736..738,781..783,832..834,
                     838..849,853..855,889..891,895..897,901..903,907..909,
                     913..915,919..921,940..942,946..954,958..966,973..978,
                     985..987)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     exon            550..697
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            698..801
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            802..919
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            920..972
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1383
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgaggcg agcggagccc gggagcccgg agcctagcgg gagggaggag ggcggagggg
       61 gcgcgcgggg cggggggcgc ggagcggggc ggggccggcg gcaggaccca ctgctcctcc
      121 ccccagggcc cccgcgcggc ccccggtcgc ccgggcagcg gaggcagcgg cgccggcgga
      181 agagctcgca ccccggcccc ggcccgcccc ggcagagaag cccgtacagg tcccaggaag
      241 gtggcgtcag catctgcagc cgcgccgacg ttgtctgagc ctccgcggag gacccaggag
      301 agtcggacta ggaccagggc cccgggcctc cccacgctct ctatggaaaa gccagctgct
      361 tcaacagaac cccaagggcc tcggcccgct ttgggccgtg aaagtgtcca ggtgcccgat
      421 gaccaggact tccgcagttt tcggtcagag tgtgaggccg aggtgggctg gaacctgacc
      481 tacagcaagg ccggtgtgtc tgtgtgggtg caggctgtgg agatggatcg aactctgcac
      541 aagatcaagt gcaggatgga atgctgtgac gtaccagctg agacgctcta cgatgtcctg
      601 cacgacatag aataccgaaa gaagtgggac agtaatgtca tcgagacatt cgacatcgct
      661 cgactgactg tcaacgctga cgtaggatat tactcctgga ggtgtcccaa gcccctgaag
      721 aaccgtgatg tcatcaccct ccgctcctgg ctccccatgg gcgctgatta catcattatg
      781 aactactcag tgaaacaccc taaataccca cctcggaaag acttggtccg agctgtgtcc
      841 atccagacgg gctacctcat ccagagcacg gggcccaaga gctgtgtcat cacctacctg
      901 gcccaagtgg accccaaagg ctccttaccc aagtgggtgg tgaataagtc atctcagttc
      961 ctggccccca aggccatgaa gaagatgtac aaggcctgca tcaagtaccc tgagtggaag
     1021 cagaaacacc agccacattt caagccatgg ctgcacccgg agcagagccc gttacccagc
     1081 ctggcgctgt cagagctgtc ggtgcaacac gcagactcac tggagaacat cgacgagagc
     1141 gccgtgacag agagccggga ggagcgggcg ggtggagcag gagagggcag cgatgacgac
     1201 acctcgctca cctgagaacc gcctctcttc aaggaccaag acaggactgg ggtggaaccc
     1261 tggggcactg agccttctgc acttcctccc ttcccccacc tgccttttgg gggcactggg
     1321 ctcctgctca ggtggctgcg gcatggctgg acatggcccc aataaatgaa ccacacagcc
     1381 cca
//
LOCUS       NM_001438271            2742 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus FLT3-interacting zinc finger 1 (Fiz1), transcript
            variant 2, mRNA.
ACCESSION   NM_001438271 XM_006228252
VERSION     NM_001438271.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Tsuruyama,T., Imai,Y., Takeuchi,H., Hiratsuka,T., Maruyama,Y.,
            Kanaya,K., Kaszynski,R., Jin,G., Okuno,T., Ozeki,M., Nakamura,T.,
            Takakuwa,T., Manabe,T., Tamaki,K. and Hiai,H.
  TITLE     Dual retrovirus integration tagging: identification of new
            signaling molecules Fiz1 and Hipk2 that are involved in the IL-7
            signaling pathway in B lymphoblastic lymphomas
  JOURNAL   J Leukoc Biol 88 (1), 107-116 (2010)
   PUBMED   20360400
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Wolf,I. and Rohrschneider,L.R.
  TITLE     Fiz1, a novel zinc finger protein interacting with the receptor
            tyrosine kinase Flt3
  JOURNAL   J Biol Chem 274 (30), 21478-21484 (1999)
   PUBMED   10409713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228252.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.611884.1,
                                           SRR22582419.767815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000001.1  77857625-77857849
            226-561             JAXUCZ010000001.1  77859036-77859371
            562-2742            JAXUCZ010000001.1  77862383-77864563
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2742
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="FLT3-interacting zinc finger 1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
     exon            1..225
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    154..156
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="upstream in-frame stop codon"
     exon            226..561
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1752
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Flt3 interacting zinc finger protein 1"
                     /codon_start=1
                     /product="flt3-interacting zinc finger protein 1"
                     /protein_id="NP_001425200.1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
                     /translation="MDDPSLPVVPAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRH
                     FARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQV
                     VHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNV
                     GPCSVCGGGGSGGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAA
                     HWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSSAPPTQVWASGGAPEVAGEG
                     DTAEVGATPPTWDAGLLLSPTGAGVPKLEALLPEDEGAGNAQAPAAAAEASSEDTLYQ
                     CDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGKGSGEAAP
                     DGEGEQVAGGPGPGSSSRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGK
                     FFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD"
     misc_feature    334..402
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    334..402
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    340..402
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    340..402
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    376..453
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    376..453
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    424..486
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    424..486
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(439..441,445..447,451..453,457..462,469..474,
                     481..483,523..525,529..531,541..546,553..558,565..567,
                     607..609,613..615,619..621,625..630,637..642)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(439..441,445..447,451..453,457..462,469..474,
                     481..483,523..525,529..531,541..546,553..558,565..567,
                     607..609,613..615,619..621,625..630,637..642)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    460..531
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    460..531
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    508..570
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    508..570
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    592..648
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    592..648
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    865..927
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    865..927
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    order(880..882,886..888,892..894,898..903,910..915,
                     922..924,964..966,970..978,982..987,997..999,1006..1008)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    order(880..882,886..888,892..894,898..903,910..915,
                     922..924,964..966,970..978,982..987,997..999,1006..1008)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    949..1011
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    949..1011
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1507..1569
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1507..1569
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1522..1524,1528..1530,1534..1536,1540..1545,
                     1552..1557,1564..1566,1606..1608,1612..1614,1624..1629,
                     1636..1641,1648..1650,1690..1692,1696..1698,1702..1704,
                     1708..1713,1720..1725,1732..1734)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1522..1524,1528..1530,1534..1536,1540..1545,
                     1552..1557,1564..1566,1606..1608,1612..1614,1624..1629,
                     1636..1641,1648..1650,1690..1692,1696..1698,1702..1704,
                     1708..1713,1720..1725,1732..1734)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1543..1620
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1543..1620
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1591..1653
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1591..1653
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1669..1737
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1669..1737
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1675..1737
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1675..1737
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            562..2742
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggaagt gacgctgacc tcgctgccca aaatgtcggc gcccagaggg aggtgtaagt
       61 aattaaacag gaaagcggac agactttccc ggcctcccgg ggtcctgcct ggtctccaag
      121 acctccgcaa cgcaaaagca aggtggtctc gcctagtccc ccggccgcct gacctgcccc
      181 cgccctggac gccggagact gcaccttcta gggacaggga aagggagaaa gccccaagct
      241 accaccaaac ctcccaccat ggatgacccc tcgcttcctg tggttcctgc tgctccaggg
      301 ccagcgccat ctgccactgc gcctcgggtc ccctttcact gcagcgaatg tggcaagagc
      361 ttccgttacc gatccgacct gaggcgccat tttgctcgac acacagcgct caagccccac
      421 gcatgtcctc gatgcggcaa gggcttcaag catagcttca acttggctaa ccacctgcgc
      481 tcacacaccg gtgagcgacc ctaccgatgt tccgcctgcc ctaagggatt ccgagactcc
      541 actggcctgc tgcaccacca ggtcgtccac actggtgaga agccctactg ctgtttggtc
      601 tgcgagctcc gcttctcctc tcgctccagc ctgggccgcc atctcaagcg tcagcaccgg
      661 ggcacacttc cctctcccct gcagcctagc ccgggcctgc ctcccttgag ctccccctgc
      721 tcagtatgtt gcaacgttgg tccctgctca gtttgtggag gtggagggtc cggtggagga
      781 gagggcctgg agggagctgg agcgaccagc tggggactgg cagaggctgc agcagctgcg
      841 gcagcttcgc tgcccccatt tgcatgtggt gcctgtgcca ggcgttttga ccatggtcgg
      901 gagctggcag cccactgggc tgcacacact gatgtgaagc cattcaagtg cccgcgttgt
      961 gagcgcgact tcaatgcacc tgcgctgctg gaacgccaca agctcacaca cgacctgcag
     1021 gggagcagtg cacctccaac acaggtttgg gcctcgggtg gggctccaga ggtggcagga
     1081 gagggtgaca cagcggaggt gggggccacc ccaccaactt gggacgccgg gctactcctg
     1141 agccctactg gtgcaggcgt tcccaaactg gaggcactgc ttcccgagga tgagggcgct
     1201 gggaatgccc aggctccggc tgcggcagcc gaagcatcct cagaagacac actgtaccaa
     1261 tgcgactgcg ggaccttctt cgcgtctgcc cctgctttag ccagccatct agaggcgcac
     1321 tctggcccag ccacgtacgg ctgtggccat tgcggggcgc tgtacgcagc actggccgcc
     1381 ctggaggagc atcggcgtgc aagccatggt aagggcagcg gggaggcagc ccccgacggt
     1441 gagggtgagc aggtggctgg agggcccgga cccggttcct ccagccgtgg caagaaaatc
     1501 tttggctgtt ctgagtgcga gaagttgttc cgctctcctc gagacctgga aaggcatgtg
     1561 ctggtccata ctggggaaaa gccattcccg tgcctggagt gtggcaagtt cttccgccat
     1621 gagtgctacc tcaagcgtca ccggctgctg catggcacag agcggccctt cccctgccac
     1681 atctgtggca agggcttcat cacgcttagc aacctctcca ggcacctgaa gctacacagg
     1741 ggcatggact gaataaccag gacgcccctg cccactaagt ccagagccag accatgagat
     1801 gagccaggcc cctgcctgga aaaatggtgc cgcccagaac ccacatagga ccacagtgaa
     1861 gcatctttta gcaaagggat ccaagaacat aattgttggg gaatttctct ctgaaatcta
     1921 cagagactct tgactttgag acccctggaa tgtggcatgt tcaaatcagc tggcctccga
     1981 gaccggtgac gtagtaatga aaacgggtct gcactcacat ctctcagcag ataacatgtg
     2041 ggcacctcca tggtgttaac cacccaccac tccctgtgag ccatcattcc aggtgacctt
     2101 cattagggaa tgggggtggg gcaatatctt gaactcctcc aggatcccct ccagatgata
     2161 cctgtcagcc actggtggcc ccagaaaatg agtataaccg aaatctgcct tccccccatt
     2221 ttgcttccta tactgaaaga ggaccagggt agataccccc caccttcaat taacccacta
     2281 tcagattagg tctcccttac tgcagaatgg tctgacccta ctggtctccc ccatcctaaa
     2341 cactagatta gactggccca aagtctcccc gctctttagg ttgtactgac ccagatgcac
     2401 atactcctat ccacttagaa tgggctggtg tctggaatgg ttatggccta accccactct
     2461 ccttagagta atagggcaga cattccctta tgctgtagag cgcaatcctt tgaccacagt
     2521 tgtcccaatc ctgtgacctg gtggaggtgg tagacattga ggttttcctc ccccttgact
     2581 tgtagtactt tggtcttccc atcactacaa cttgactctt tgttccaacg ccacaagggg
     2641 ataggggaac ttggccaggg gtttctcccc tgtgagcctc aacctgaccc ctgacccctc
     2701 tccccaatgt ctctgggact ccaataaacc tcattcaatc ac
//
LOCUS       NM_001438280            3506 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), transcript
            variant 5, mRNA.
ACCESSION   NM_001438280 XM_017588892
VERSION     NM_001438280.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 3506)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 3506)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_017588892.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.537864.1,
                                           SRR26643298.1441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  79143873-79144074   c
            203-381             JAXUCZ010000001.1  79140675-79140853   c
            382-493             JAXUCZ010000001.1  79138630-79138741   c
            494-714             JAXUCZ010000001.1  79137661-79137881   c
            715-810             JAXUCZ010000001.1  79135186-79135281   c
            811-883             JAXUCZ010000001.1  79134012-79134084   c
            884-959             JAXUCZ010000001.1  79133654-79133729   c
            960-1015            JAXUCZ010000001.1  79132689-79132744   c
            1016-1108           JAXUCZ010000001.1  79132406-79132498   c
            1109-1201           JAXUCZ010000001.1  79131894-79131986   c
            1202-1344           JAXUCZ010000001.1  79128304-79128446   c
            1345-1418           JAXUCZ010000001.1  79127788-79127861   c
            1419-3506           JAXUCZ010000001.1  79125564-79127651   c
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3506
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..202
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1453
                     /gene="Ttyh1"
                     /note="isoform 3 is encoded by transcript variant 5;
                     protein tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1 isoform 3"
                     /protein_id="NP_001425209.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPRNPSALCSGSLPSEPPCQCGLPLLFAPF
                     LGCWRRPH"
     misc_feature    101..1348
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    101..1348
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     exon            203..381
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..714
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..810
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..959
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1015
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1344
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1418
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..3506
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccggct ccgcccgcgc cccgcacagc accgaggctc ccggcccggt ccgccccgct
       61 gcccctcccc ggggccatgg gggcaccccc gggctaccga ccctctgcct gggtgcatct
      121 cctccaccag ctgccccgtg ccgacttcca gctccgcccg gtgcccagcg gctttgctcc
      181 ccgcgaccaa gagtaccagc aggccctgct gctggtggca gccttggctg ggctgggttt
      241 gggcctgagc ctcatcttca tcgctgtcta cctcatccgc ttctgctgct gcaggcctcc
      301 agaaccccct ggggccaaga gtcccccacc cggaggaggc tgtgtcacct ggagctgcat
      361 tgctgccctt ctcgtgggct gtgcaggcat tggcattggt ttctatggta acagcgagac
      421 cagtgatggg gtgtcccagc tcagctcagc actgcagcat gccaaccaca cgctcagcac
      481 cattgatgac ttggtgctgg aaacggtaga gaggctgggt gaggctgtga ggacagagct
      541 gaccaccctg gaggaagtgt tgtcagaacg cgtggagctg gtggctgcca cccggggagc
      601 cagaaggcag gctgaggcag cagctcagca cctgcaaggc ctagccttct ggcagggagt
      661 gtccctgagc ccagtacagg tggctgagga tgtgactttc gtggaggagt acaggtggct
      721 ggcctatgtc ctcctgctgc tcttggtgct tctggtttgt ctcttcaccc tcctgggcct
      781 ggccaagcag agcaagtggc tggtggttgt gatgaccgcc atgagtctcc tggtgcttgt
      841 cctgagctgg ggttctatgg gcctagaggc tgccacagct gtgggtctca gtgacttctg
      901 ctccaaccca gacacctatg tgctgaactt gacccaggag gagacaggaa tcagttcaga
      961 catcctcaac tattatttcc tgtgcaacca ggcggtctcc aaccccttcc aacagaggct
     1021 gactctgtcc cagcgtgctc tagccagcat ccactctcag ctgcaaggcc tggagcggga
     1081 agctagccct caatttcctg ctgcacagaa gcccttgtta tccttggagg agacgctgaa
     1141 tgtgacagaa agaagcttcc accagttggt ggcactgctg cactgccgca gtctgcacaa
     1201 ggactatggc tcagcactcc gaggcctgtg tgaagatgcc ctagagggcc tgctgttcct
     1261 gatgctcttt tctctcctgt ctgccggggc cctagccacc actctttgca gcctgccccg
     1321 tgcctgggct ctcttcccac ccaggaatcc aagcgctttg tgcagtggca gtcttccatc
     1381 tgagcccccc tgccagtgtg gcctgcctct cctctttgct cctttccttg gctgctggag
     1441 aaggccccac taacctgacc ttggctgggc tctgaccatt aacactgctg gctatggaca
     1501 cctcacatag gatgacatcc tgttctggcc ctaacactcc cccattccca tttctcctta
     1561 gcacaggtgg ttgctggggt ggcacaatag agaccagggc tgtctgggaa gggagctgac
     1621 catacagcgt ggtgttcctc acctccgggt accagccctg tccttggagg gataaagctg
     1681 gacacaggtg caggcatggc catttcctgc catatgccag tgatctcaac tgatggcact
     1741 aacttggaag agggcggatt tgaaataaaa gggaagactt tattttacaa gtacctaggt
     1801 ccttcttatc acccctgccc caatcctgga gaaagaagtc ttgactgggc taggggactc
     1861 ctctggtgtt tgaaaggcaa ctctcctctt gtccaggctc agcactgctt tgcttctgaa
     1921 agtcacgtgt gaatcctgac aagggggaag aagcagatcc cagaagagag taagcctaac
     1981 actaaattaa acatgcgtgc atccacagga agagtcaacc ttccagtcac gtggaatgtt
     2041 caaagcctgc tgggattagg aacggtgtgg aatcgaatca acttgcttcc tagcagctca
     2101 tatcctacac aagaacgtca gaaaactaac gcttgtttca ggatagggac agaaatcttc
     2161 agagagaagt agaatatttg ctcgtaatgc taccacggtg atgtaaaggg agaaggttta
     2221 aggaagataa tataaatcca gacaggaaaa gatgaggcaa tcatcaagtt gtcaagtaaa
     2281 aacaaacatg gcagagtcaa aagggaaatt tattgtctgg ggaacaattc ctatgtagtt
     2341 cttatttgtt aaaaaaaaaa aaagtagcac acatgacaaa ggaaaacatt gttgttaata
     2401 gataaacata attcaaaaag cttctattat ctaacaaaaa acagaccaac tcaatttagt
     2461 aataagtaac tgagatgaac gtacaaggaa acaaaatccc caagacaaag gataaaactg
     2521 gggatttttg gttttcattt tggtttttgg ttttttgaga caggctttct ttgtaataga
     2581 cctgggtgtc ctggaactct ttgtagacca ggctggcctt gacctcacag agaacagcct
     2641 gcctctgcct ccctagtact gagattaaag catgtatcac catatcacca gctaaaatgt
     2701 tcaagttcta atgattagca aacacgatgt gctactttcc cctttctagt acctacttgt
     2761 tgtggacttt aaagtggggt gttggctggt gctagtctgg aggctcaggg aaaaagttct
     2821 ctgaatatgc tgctcagagg cggtgaatca ccagctatgt gaaaataata attaaaacaa
     2881 acaaacaaaa caaaaccctg ctcacatctc ttaacctggt aatcctttgg ggcacaagct
     2941 tccagtaaga gatgaacagg caacccttgg ctcagttaaa ccctggagac agaaatgttc
     3001 acaaaaggaa gaacagtaat gtagagcagg atcctcaagt tcacagtggc aagtggggta
     3061 cagaggcacc aggggtatcc ctggccctgt gctggttgga agcctctggg tcctagacct
     3121 ggcaccacta tgttaatgtg gacaagttat ctgactggtt gaacctcagt tgaatggtga
     3181 agcaaatggg tatcataaat ccagaaaaca gctcttgaca tgataggtaa taagcaggat
     3241 aaatgcagca tgatgttctg ggttacattc tggtgcacag aaaacattag taggaaaagt
     3301 acccacttct aaagtctgcg gcttagttca gagtattaaa gcaatgtcaa tttcttactt
     3361 ttaacaaata aaccatggtg aattcgaggt gtggaatcta gcaatagggg aaactgggca
     3421 gtgtgctcaa ttcctgtatt acctttgcaa tttttatttc tgtaaactta aatttattct
     3481 aaaataaaag ttcattataa aaagga
//
LOCUS       NM_001438268            4242 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 418 (Zfp418), transcript
            variant 4, mRNA.
ACCESSION   NM_001438268
VERSION     NM_001438268.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4242)
  AUTHORS   Singh,S.R., Meyer-Jens,M., Alizoti,E., Bacon,W.C., Davis,G.,
            Osinska,H., Gulick,J., Reischmann-Dusener,S., Orthey,E.,
            McLendon,P.M., Molkentin,J.D., Schlossarek,S., Robbins,J. and
            Carrier,L.
  TITLE     A high-throughput screening identifies ZNF418 as a novel regulator
            of the ubiquitin-proteasome system and autophagy-lysosomal pathway
  JOURNAL   Autophagy 17 (10), 3124-3139 (2021)
   PUBMED   33249983
REFERENCE   2  (bases 1 to 4242)
  AUTHORS   Pan,L., Sheng,M., Huang,Z., Zhu,Z., Xu,C., Teng,L., He,L., Gu,C.,
            Yi,C. and Li,J.
  TITLE     Zinc-finger protein 418 overexpression protects against cardiac
            hypertrophy and fibrosis
  JOURNAL   PLoS One 12 (10), e0186635 (2017)
   PUBMED   29065170
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1959078.1,
                                           SRR26360194.475553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000001.1  75614540-75614743
            205-289             JAXUCZ010000001.1  75617931-75618015
            290-4242            JAXUCZ010000001.1  75623415-75627367
FEATURES             Location/Qualifiers
     source          1..4242
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..4242
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="zinc finger protein 418"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
     exon            1..204
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream in-frame stop codon"
     misc_feature    109..111
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MKAKKTVGSSGSCVRAPALSTEP"
     CDS             178..2079
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="zinc finger protein 418 isoform 4"
                     /protein_id="NP_001425197.1"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
                     /translation="MAAVKHLAQEEWKLLDEAQRLLYLDVMLENFTLISSLVYRYEAE
                     AEEKTCAQSLSQTEAPQVRTPKQGQLRQKPHPSDICITVLKDILHLNDLPGQKPYLTE
                     VCTKPQDHKHHRAKNWLKRDVDSLVKSCIFHVAGNPFICSKIGEKFPAIWNLLQPKDI
                     PNGEKQNKIKRGKAFHRDKNNSESDEYKKSSSPQHRLHEYPGVCSAKGGFESNSCEQD
                     LNKYSPAPFRMDQTENRPYECHVCGKWFGQKATLRIHQRRHTGEKPYKCGECGKSFCQ
                     SSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWPYECSDCGRLFRQIV
                     SLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANL
                     IKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFKQYFYLIE
                     HRRIHTTTEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEECGKAFEYKSRLKRHQ
                     RTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKPYHCDQCGKCFSRRADLVKHQRV
                     HTGERPYTCGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQLLHT
                     GEKPYKCSK"
     misc_feature    <202..288
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    <202..288
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    892..954
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    892..954
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(907..909,913..915,919..921,925..930,937..942,
                     949..951,991..993,997..999,1009..1014,1021..1026,
                     1033..1035,1075..1077,1081..1083,1087..1089,1093..1098,
                     1105..1110,1117..1119)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(907..909,913..915,919..921,925..930,937..942,
                     949..951,991..993,997..999,1009..1014,1021..1026,
                     1033..1035,1075..1077,1081..1083,1087..1089,1093..1098,
                     1105..1110,1117..1119)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    964..2037
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    964..2037
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    976..1038
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    976..1038
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1060..1122
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1060..1122
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1144..1206
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1144..1206
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1228..1290
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1228..1290
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1243..1245,1249..1251,1255..1257,1261..1266,
                     1273..1278,1285..1287,1327..1329,1333..1335,1345..1350,
                     1357..1362,1369..1371,1411..1413,1417..1419,1423..1425,
                     1429..1434,1441..1446,1453..1455)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1243..1245,1249..1251,1255..1257,1261..1266,
                     1273..1278,1285..1287,1327..1329,1333..1335,1345..1350,
                     1357..1362,1369..1371,1411..1413,1417..1419,1423..1425,
                     1429..1434,1441..1446,1453..1455)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1312..1374
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1312..1374
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1396..1458
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1396..1458
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1480..1542
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1480..1542
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1564..1626
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1564..1626
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1648..1710
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1648..1710
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1732..1794
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1732..1794
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1816..1878
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1816..1878
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1831..1833,1837..1839,1843..1845,1849..1854,
                     1861..1866,1873..1875,1915..1917,1921..1923,1933..1938,
                     1945..1950,1957..1959,1999..2001,2005..2007,2011..2013,
                     2017..2022,2029..2034,2041..2043)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1831..1833,1837..1839,1843..1845,1849..1854,
                     1861..1866,1873..1875,1915..1917,1921..1923,1933..1938,
                     1945..1950,1957..1959,1999..2001,2005..2007,2011..2013,
                     2017..2022,2029..2034,2041..2043)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1900..1962
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1900..1962
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1984..2046
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1984..2046
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            205..289
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            290..4242
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcgtc ctgtctttgg tttaacttcc catgggttgg tatttggagg attctgagct
       61 ttaggatcgc caaattatac tcaagttaag agagagagcc ggcgcaggat gaaggccaag
      121 aagaccgtag gcagcagcgg tagctgtgtc cgggcccctg cgttgtcaac agagccgatg
      181 gcggctgtga agcacctggc tcaggaagag tggaagctcc tggatgaagc tcagaggcta
      241 ctgtatcttg atgtgatgct ggagaatttt acccttatat cctcactggt ttatcggtat
      301 gaagcagagg ctgaagaaaa aacctgtgca cagagtcttt cacaaactga agcaccacaa
      361 gtcaggactc cgaagcaagg tcaactcagg cagaagcctc atccctctga catctgtatc
      421 accgtcctga aagatatctt gcatctgaac gacctacctg ggcaaaagcc gtatttgacc
      481 gaagtgtgta caaagcccca ggaccataag catcacagag ccaagaattg gttaaagaga
      541 gacgtggact cccttgtgaa gagctgtata ttccatgtgg cagggaaccc tttcatctgt
      601 agtaagattg gagagaaatt cccagctata tggaatcttc tccaacccaa ggacatcccc
      661 aacggtgaga aacaaaataa aattaagcgt ggaaaggctt ttcacaggga taaaaataat
      721 tctgaatcag atgaatataa gaaatcttcc agcccccaac acaggcttca tgaataccca
      781 ggagtttgca gtgcaaaggg gggttttgaa tctaacagtt gtgagcaaga cttaaacaag
      841 tactcacctg caccattccg gatggaccag actgaaaacc gaccatatga gtgtcatgtc
      901 tgtggaaaat ggtttggcca gaaagccaca cttagaatac accagagacg tcataccgga
      961 gaaaaaccat ataagtgtgg tgaatgtgga aagtcttttt gtcaaagctc taacctaagt
     1021 gaacactgca gagttcatag tggagaaaga ccttttgagt gtctggaatg tgggaaagcc
     1081 tttgggtgcc attctagtct tctgcggcac cagagaacac acactggaga atggccatat
     1141 gaatgcagtg actgtgggag actgtttaga cagattgtca gcctgattac acaccagagg
     1201 actcacacta ccgagaagcc ttatgaatgt ggacagtgtg agaagtcttt tagtcacaaa
     1261 gccactctta ctgtacatca gagagttcac actggggaaa agccctatca ctgtgaagcc
     1321 tgtgggaaat ccttcagcca aagtgccaac cttattaaac actccaaaat tcacactgga
     1381 gaaaagcctt atgagtgtgg agaatgcggt ctatgctttc gccagagagc taccctcatg
     1441 aaacaccaga gaacccacac gtcagaaagg ccttatgaat gtagagaatg tggtaagttc
     1501 tttaaacaat acttctacct cattgaacac cgtaggattc acaccacaac agaattttat
     1561 gagtgtgaac agtgcgggaa gtcttatacc caaaaagcca cccttatcag acaccaacga
     1621 gtccacacag gagagagtcc ttataaatgt gaggagtgtg gaaaagcctt tgaatacaaa
     1681 tccagactta agcgacatca aagaacgcac actggtgaaa ggccttatga gtgtgccaaa
     1741 tgtgggaaat tcttcagaga aagctacaat cttgctgaac accagaaaat tcacactaaa
     1801 gcaaagcctt accattgtga tcagtgtggg aagtgtttta gccggagagc tgacttggtt
     1861 aaacaccaga gagttcacac tggtgaaaga ccttatactt gtggtgaatg tgggaagacc
     1921 ttcagccgaa ctaccaacct tgttcaacac agaagaattc acactgggga acggccatac
     1981 gagtgtgacc agtgtgggaa atcttttagc caggtgtcta ccctcactcg acatcagcta
     2041 cttcacactg gagaaaaacc gtataagtgt agcaaatgaa ggaaagtcta gacagccctc
     2101 tagcatcttc taacaccaaa agatagacca tcacagctcc cggaagccaa cccttgaaag
     2161 caccctcagg cctccaagga tattacattg ttcactgtaa caaactagag agcctcatag
     2221 agttctaggt catgtaattt gtaccagagc tagcctgcat gttctggaca gtctgtaccc
     2281 cttgccagag ttaaagagct gtcataatgt ctcatagaca ctgtctcttc tctagcacct
     2341 tgcactgagt gcatatgcac caccaccacc ccaccccacc cttgcaacat gccgtactct
     2401 ccccttccct aatagaagcc tcaacttcct gtgccttgca aatgaccttg atcccttttt
     2461 ctcactggat atttctgggt ctgtattttg cctaaaggaa catggtctgg gatgagtggg
     2521 aggctccagc aaggattatc ttctcaagtc tgtctcacat gattcgtgtg actgtttaca
     2581 tactccaaat cactagccag gaacttcctg tcaggatgtg caataataaa agaccttatt
     2641 tttttttccc ccatgtactt ttaatcaaga gtttctattc acagacttag gcagccaaaa
     2701 tactatgata ggtcctgttt ttgttttgtt taattatttt tatttacatt caagccgttg
     2761 ccttccatca cctctccctc aagtcttcat ccccctcctt tttctccttg ccttcaagag
     2821 ggtgcccctg ccaccaggcc tcccccttcc ctggtgcctc aagtctctca aggcgtatct
     2881 tctcccactg aggccagacc acgcagtcct ctgatatata tgtgctaggg gttgcctgtt
     2941 tggtaggctc tgtttatata gaaattgtaa cagtgtttgg gttttttatt taatatttat
     3001 ttattgaatg tacatgtgtg ctctgtcttc atgcacacca gaagagggaa tcaattctga
     3061 gccatcatgt ggttgctgga attgaactca ggccctccag aagatcagcc agtgctctta
     3121 acatctgagc catctctcct tccctggaac aggtcttgag gctgcaccat tcatgcctca
     3181 gcatgggtaa tgggaaagag tagctctcgt ttatgttgct ttccaaaacc tttagtggaa
     3241 caaagcaggg tgttcagtcc tagctttgtg ctttttttgt ttgttgttgg gaggaaggtg
     3301 ttttgttttt agactaccct gaggtcactt gttggaactg caacattcag tgctcttaga
     3361 atagctttaa cttatcccat cattcccaca tggtctgacc tgattatgcc caagattgtc
     3421 gaagagaaac ttttctatga ggttcataga caccaagtcc ataattccaa atgtcacttg
     3481 aaaaattagg agaaccaaat aggaacaata acgggtagat taatacaagc tttaagggtc
     3541 ggagaggtgg ctcagcagtt aagagcaccc gactactctt ccagaggtcc tgagttcaat
     3601 tcccagcaac cacatggtgg ctcacaacca tctgtaaaga gatccgatgt cctcttctgt
     3661 tgtatctgaa gacagctcag tgtacttatt tataataaat gaataaatct tttttaaaaa
     3721 atacaggttt tgataattga aaggtggggt tttatatgag aacattacct ggggattgat
     3781 tactctagag accacagata ttgcattctg gaaaataatt tgcctgtatc ttgtgtcctg
     3841 aaatcttaac tgagtctgaa ttcatgctgt aacttatagc cagatttaca gtgagcaaca
     3901 tcagcaaaac gccaatcaga aagattcaaa agcaggcagt tttgccagga acagaatgta
     3961 ttgggagata caaagaagcc atagttacta atgggatcac actgttaaaa gaaactaagt
     4021 actttgtact aggggtgtag aaaaataata aagatacctt gatggctcag cttctcttcc
     4081 agagatcctg agttccattc ccaggaactg catggtggct cacaagcatt tattaaggaa
     4141 tctgatgccc tcttctggta tgtaggtgta tgtgcagata gcactcactt ataaataaat
     4201 aaataaataa ataaataaat aatttttaat ttgttttaaa aa
//
LOCUS       NM_001438292            1295 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide A
            (Snrpa), transcript variant 3, mRNA.
ACCESSION   NM_001438292
VERSION     NM_001438292.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Kondo,Y., Oubridge,C., van Roon,A.M. and Nagai,K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Bai,B., Hales,C.M., Chen,P.C., Gozal,Y., Dammer,E.B., Fritz,J.J.,
            Wang,X., Xia,Q., Duong,D.M., Street,C., Cantero,G., Cheng,D.,
            Jones,D.R., Wu,Z., Li,Y., Diner,I., Heilman,C.J., Rees,H.D., Wu,H.,
            Lin,L., Szulwach,K.E., Gearing,M., Mufson,E.J., Bennett,D.A.,
            Montine,T.J., Seyfried,N.T., Wingo,T.S., Sun,Y.E., Jin,P.,
            Hanfelt,J., Willcock,D.M., Levey,A., Lah,J.J. and Peng,J.
  TITLE     U1 small nuclear ribonucleoprotein complex and RNA splicing
            alterations in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16562-16567 (2013)
   PUBMED   24023061
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   5  (bases 1 to 1295)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 1295)
  AUTHORS   Novakova,Z., Man,P., Novak,P., Hozak,P. and Hodny,Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   7  (bases 1 to 1295)
  AUTHORS   Sinha,K., Perumal,K., Chen,Y. and Reddy,R.
  TITLE     Post-transcriptional adenylation of signal recognition particle RNA
            is carried out by an enzyme different from mRNA Poly(A) polymerase
  JOURNAL   J Biol Chem 274 (43), 30826-30831 (1999)
   PUBMED   10521474
REFERENCE   8  (bases 1 to 1295)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1295)
  AUTHORS   Nagai,K., Oubridge,C., Jessen,T.H., Li,J. and Evans,P.R.
  TITLE     Crystal structure of the RNA-binding domain of the U1 small nuclear
            ribonucleoprotein A
  JOURNAL   Nature 348 (6301), 515-520 (1990)
   PUBMED   2147232
REFERENCE   10 (bases 1 to 1295)
  AUTHORS   Craft,J., Mimori,T., Olsen,T.L. and Hardin,J.A.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233559.1, FQ227089.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000001.1  91617449-91617755   c
            308-480             JAXUCZ010000001.1  91615046-91615218   c
            481-657             JAXUCZ010000001.1  91613872-91614048   c
            658-831             JAXUCZ010000001.1  91611727-91611900   c
            832-920             JAXUCZ010000001.1  91611264-91611352   c
            921-1295            JAXUCZ010000001.1  91609419-91609793   c
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1295
                     /gene="Snrpa"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
     exon            1..307
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    220..222
                     /gene="Snrpa"
                     /note="upstream in-frame stop codon"
     CDS             235..1080
                     /gene="Snrpa"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_001425221.1"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
                     /translation="MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIL
                     VSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFV
                     ERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMTQAPRIMHHMPGQP
                     PYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEET
                     NELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKI
                     SFAKK"
     misc_feature    253..519
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    253..519
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    <268..>855
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    <268..>855
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    order(271..273,277..282,289..291,364..366,370..372,
                     376..396,400..402,472..474,481..483,487..510)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    order(271..273,277..282,289..291,364..366,370..372,
                     376..396,400..402,472..474,481..483,487..510)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    820..1077
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     misc_feature    820..1077
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     exon            308..480
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            481..657
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            658..831
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            832..920
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1295
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattcgtag ttaatctcta gatcttcctt aacacgcggg ctggagacgc ggagtcctag
       61 gctggctttg ttgctaagtg tgccatcctc ccccaattcc ggtcttactc tactccctcc
      121 tggaagaaag atccctgagc agagcccacc agtcctttag aacaaagaac ttgggaaacg
      181 taaggctaaa tcgctttttc ttcctcctta agcagtacct gaacatctca caccatggca
      241 gttcccgaga cccgtcccaa ccacactatt tatatcaaca atctcaatga gaagatcaag
      301 aaagatgagc tcaagaagtc cctgtatgcc atcttctccc agtttggcca gatcctggat
      361 atcctggtgt ctcggagcct gaagatgagg ggccaggcct tcgtcatctt caaggaggtc
      421 agcagtgcca ccaacgccct gcgttccatg cagggcttcc ctttctacga caagcccatg
      481 cgtatccagt acgcaaagac tgactcagac atcattgcca aaatgaaggg cacctttgtg
      541 gagagagatc gcaaacgtga gaagaggaag cccaagagtc aggagacacc tgctgccaaa
      601 aaggctgttc agggtggggc agctgcccct gtggttggcg ctgtccagcc tgtaccgggc
      661 atgccaccga tgactcaggc accccgcatc atgcaccaca tgccaggaca gcctccctac
      721 atgccaccac ctggcatgat cccgccacca ggccttgctc ctggccagat ccctcctggg
      781 gcaatgcccc cacagcagct catgcctggg cagatgccac ctgcccaacc tctctcggag
      841 aatccaccca atcacatcct gttcctcacc aacctgcctg aggagaccaa cgagctcatg
      901 ctctccatgc tcttcaacca gttccctggc ttcaaggagg tgcgtctggt ccctgggcgc
      961 catgacattg ccttcgtgga gtttgacaat gaagtgcagg ctggggcagc acgagatgcc
     1021 ctgcaaggct tcaagatcac acagaacaat gcaatgaaga tctcttttgc caagaagtag
     1081 cacctttccc tacggagtgc cccagtcccc attctggggc tgccccttcc ccctctcttg
     1141 gctcagtccc tgaaggtaag tcccccttgg gggccttctc agagccgtga gtgagtgtgt
     1201 gtctgccaca cagcattgta cccagggtct tcccagacat tgcacctggc gctgttgggt
     1261 tgtgattaaa gtgagttttt aggtttggtt tttca
//
LOCUS       NM_001438302            3127 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 220 (Rnf220), transcript
            variant 1, mRNA.
ACCESSION   NM_001438302 XM_063288245
VERSION     NM_001438302.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Ma,P., Yang,X., Kong,Q., Li,C., Yang,S., Li,Y. and Mao,B.
  TITLE     The ubiquitin ligase RNF220 enhances canonical Wnt signaling
            through USP7-mediated deubiquitination of beta-catenin
  JOURNAL   Mol Cell Biol 34 (23), 4355-4366 (2014)
   PUBMED   25266658
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063288245.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28543.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               JAXUCZ010000005.1  136197673-136198022 c
            351-1092            JAXUCZ010000005.1  136190568-136191309 c
            1093-1225           JAXUCZ010000005.1  136012745-136012877 c
            1226-1271           JAXUCZ010000005.1  136004531-136004576 c
            1272-1373           JAXUCZ010000005.1  136000843-136000944 c
            1374-1416           JAXUCZ010000005.1  135993033-135993075 c
            1417-1538           JAXUCZ010000005.1  135989870-135989991 c
            1539-1671           JAXUCZ010000005.1  135989404-135989536 c
            1672-1768           JAXUCZ010000005.1  135981970-135982066 c
            1769-1855           JAXUCZ010000005.1  135981716-135981802 c
            1856-1911           JAXUCZ010000005.1  135981554-135981609 c
            1912-1990           JAXUCZ010000005.1  135981364-135981442 c
            1991-2099           JAXUCZ010000005.1  135977575-135977683 c
            2100-2174           JAXUCZ010000005.1  135977386-135977460 c
            2175-3127           JAXUCZ010000005.1  135975738-135976690 c
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3127
                     /gene="Rnf220"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
     exon            1..350
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            351..1092
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    441..443
                     /gene="Rnf220"
                     /note="upstream in-frame stop codon"
     CDS             468..2246
                     /gene="Rnf220"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF220 isoform 1"
                     /protein_id="NP_001425231.1"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
                     /translation="MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQ
                     PRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPP
                     NLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDSESPHLRFSDADG
                     KEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFD
                     SQAPICPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASI
                     KREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQVCP
                     LCSRPLAGSEQEMSRHVEHCLSKREGSCVAEDDAVDIEHENSNRFEEYEWCGQKRIRA
                     TTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGE
                     AKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDIEK
                     ITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWL
                     RTLGAKKLCPQCNTITAPGDLRRIYL"
     misc_feature    1116..1877
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    1116..1877
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    2079..2234
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     misc_feature    2079..2234
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     exon            1093..1225
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1271
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1373
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1416
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1538
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1671
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1768
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1855
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1911
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1990
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2099
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2174
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..3127
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgtgcat gtgtgtgtga gtgtgtgtgc gcgcgcgcgt gtgtgtgcgc ctccgagtcc
       61 ctgggagagt ggaggctcat tcactgatta gagccagcgc tgagaggcag cactgctctt
      121 ctctcacacc aaccgagtct cttgatctgt acatgcaatc ccaggcagct cgcgagcaca
      181 aacccggggc cagccgcctg ctgctgctgc tgctgccgct gccgccgcca ccgccgccgc
      241 tgcccccgcc ggctctgcgc acccgggact tttcatgcac cacactctcc gtcttcttac
      301 ctcggtgtcc tgaaaagtgc gaccgttctc ccctggaatt tccacggcaa gtcttcggag
      361 ggcatgattc cccagtaata atcctcgccc tgatccaagg tgcaggttgg cctccctccc
      421 agggaagact gcttcttgcg tgacacccgc catcgaaaga gactccaatg gacttacacc
      481 gggcagcctt caagatggag aactcatcct atcttcccaa ccctctggca tccccggcac
      541 tgatggtcct ggcgtccact gccgaggcca gcagggatgc ctccatcccg tgtcagcagc
      601 cacgaccctt tggtgtacct gtctcagtag acaaagacgt tcatattccc ttcaccaatg
      661 gctcttacac ctttgcctct atgtaccacc gtcaaggtgg ggtgccgggc acttttgcca
      721 atcgtgattt ccccccttcc ttactacacc tccaccccca gtttgccccc ccaaatctag
      781 attgcacccc aatcagtatg ctaaatcaca gtggcgtggg ggcattccgt cccttcgctt
      841 ccacggagga cagggagagc tatcagtcag cctttacgcc agccaagaga ctcaagaact
      901 gtcacgactc agagtctccc cacctgcgct tctcagatgc agatggcaag gaatatgact
      961 ttgggacaca gctgccgtcc agctcccctg gttcacttaa ggttgatgat actgggaaga
     1021 agatctttgc cgtgtctggc ctcatctctg accgggaaac ctcctcgagt ccagaggatc
     1081 ggaatgacag atgtaagaag aaagcagtag cgttgtttga cagccaagcc ccgatctgcc
     1141 ccatctgcca agtcctgctg aggcccagcg agttgcagga acatatggag caagaactgg
     1201 agcagctggc ccaactgcct gccagcaaaa attcccttct gaaggatgcc atggctccgg
     1261 gcacccccaa gtccctcctg ttgtctgctt ccatcaagag ggaaggagac tctccaaccg
     1321 cttccccaca ctcctctgcc accgaggacc tgcaccactc agacagatac cagaccttct
     1381 tgcgagtgcg agccaaccgg caaacccgac tgaatgctcg gattgggaaa atgaaacgga
     1441 ggaagcaaga tgaagggcag gtatgtcccc tgtgcagccg ccccctggca ggatcggagc
     1501 aggagatgag taggcatgtg gagcattgcc tttctaagag ggaaggctcc tgcgtggctg
     1561 aggatgacgc cgtggacatc gagcatgaga acagcaaccg ctttgaggag tatgagtggt
     1621 gtgggcagaa gcggatacgg gccaccacgc tcctggaagg tggcttccga ggctccggct
     1681 tcgttatgtg cagtggtaaa gagaatccag acagtgatgc tgacctggat gtggatggag
     1741 atgacactct ggagtatggg aaaccacaat acacagaggc tgatgtcatc ccatgcacag
     1801 gagaagagcc tggtgaagcc aaggagagag aggcactccg gggcgcagtc ctaaatggtg
     1861 gccccccgag cacccgcatc acacctgagt tctctaaatg ggccagtgat gagatgccgt
     1921 ccaccagcaa tggtgaaagc agcaagcagg aagccatgca gaagacctgc aagaacagtg
     1981 acattgagaa aatcaccgaa gattcagctg taactacctt tgaggctcta aaggctcggg
     2041 tcagggagct tgaacggcag ctatctcggg gtgaccgata caaatgcctc atctgcatgg
     2101 actcatactc aatgccgctg acgtcgatcc agtgttggca tgtgcactgt gaagagtgtt
     2161 ggcttcggac tctgggtgcc aagaagctct gccctcagtg caacaccatc acagcccctg
     2221 gagacctgcg gaggatctac ttatgagcta gctgtccagg caggccctgc ctcgagcaaa
     2281 cccctgctcc agcctctgtg acagtgaccg cccctccccc cttgtacata cttgcacaca
     2341 ggtcccccgt gtacatacat gcatatacac acccaaacac acatagagga ctctggagcc
     2401 agagtggaac agccctgcct gcttgttcct tctgaacttg gggaccatgc ctctttggac
     2461 tctgtttcca gggttggcag gaaggtggtt tgggaagtat agcaggacga ggctcctgag
     2521 atccatcccc gagactgact gacagacacg caaacaccag actgaagcac atgtaatata
     2581 gactgtgtat gtttacaatg ttgtgtataa atgggacact ttgccctcta ccaccttccc
     2641 ctttgggtgt atgattttct tcttttataa tgactcctgg aagcagtgcc ccttcagggc
     2701 tggctggggg ctcggcccaa ccacctctta gggtgcctgc ctcttcctct cccatggcat
     2761 cccttccctt ccccatgtgc tcagtgttca gtggtgtata tttcttctcc caaacacggg
     2821 gcgtgtgccc cgaggggtct gatcctctcc ttagtcttag ctcatggggc tcctcatgag
     2881 gagctggggg tagggtggaa tgggaccaag caggaacagg ctgcaggctg gctggctgag
     2941 ggtgcctggc tgcccagcct gctgttgaga accacccctg gggtagacac tgctcccagg
     3001 ggaagtgctg gccccgcccc tgtgtgggcc ctgtggtgtg atgctgtgtc tgtatattct
     3061 atacaaaggt acttgtcctt tccctttgta aactacattt gacatggatt aaaacagtat
     3121 aaaccag
//
LOCUS       NM_001011930            1814 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus thyroid hormone receptor interactor 13 (Trip13),
            transcript variant 2, mRNA.
ACCESSION   NM_001011930 XM_217741
VERSION     NM_001011930.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Yost,S., de Wolf,B., Hanks,S., Zachariou,A., Marcozzi,C.,
            Clarke,M., de Voer,R., Etemad,B., Uijttewaal,E., Ramsay,E.,
            Wylie,H., Elliott,A., Picton,S., Smith,A., Smithson,S., Seal,S.,
            Ruark,E., Houge,G., Pines,J., Kops,G.J.P.L. and Rahman,N.
  TITLE     Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome
            missegregation
  JOURNAL   Nat Genet 49 (7), 1148-1151 (2017)
   PUBMED   28553959
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Roig,I., Dowdle,J.A., Toth,A., de Rooij,D.G., Jasin,M. and
            Keeney,S.
  TITLE     Mouse TRIP13/PCH2 is required for recombination and normal
            higher-order chromosome structure during meiosis
  JOURNAL   PLoS Genet 6 (8), e1001062 (2010)
   PUBMED   20711356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001011930.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000001.1  31185684-31185902
            220-385             JAXUCZ010000001.1  31186876-31187041
            386-515             JAXUCZ010000001.1  31189173-31189302
            516-571             JAXUCZ010000001.1  31192046-31192101
            572-662             JAXUCZ010000001.1  31192635-31192725
            663-735             JAXUCZ010000001.1  31194352-31194424
            736-799             JAXUCZ010000001.1  31196608-31196671
            800-886             JAXUCZ010000001.1  31197452-31197538
            887-993             JAXUCZ010000001.1  31197790-31197896
            994-1147            JAXUCZ010000001.1  31199288-31199441
            1148-1260           JAXUCZ010000001.1  31201634-31201746
            1261-1330           JAXUCZ010000001.1  31202581-31202650
            1331-1462           JAXUCZ010000001.1  31203812-31203943
            1463-1814           JAXUCZ010000001.1  31230287-31230638
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1814
                     /gene="Trip13"
                     /note="thyroid hormone receptor interactor 13"
                     /db_xref="GeneID:292206"
                     /db_xref="RGD:1308516"
     exon            1..219
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1426
                     /gene="Trip13"
                     /note="thyroid receptor-interacting protein 13; TRIP-13;
                     TR-interacting protein 13"
                     /codon_start=1
                     /product="pachytene checkpoint protein 2 homolog"
                     /protein_id="NP_001011930.1"
                     /db_xref="GeneID:292206"
                     /db_xref="RGD:1308516"
                     /translation="MDDAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKQSVYR
                     LLKRHNIVFGDYVWTEFDEPFLTRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQL
                     NEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFS
                     DKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLF
                     SKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRV
                     VNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSC
                     LEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLP
                     FLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAHV"
     misc_feature    128..130
                     /gene="Trip13"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q15645; propagated from
                     UniProtKB/Swiss-Prot (Q5XHZ9.1); acetylation site"
     misc_feature    227..>742
                     /gene="Trip13"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; Region: McrB; COG1401"
                     /db_xref="CDD:441011"
     misc_feature    227..>742
                     /gene="Trip13"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; Region: McrB; COG1401"
                     /db_xref="CDD:441011"
     misc_feature    488..1084
                     /gene="Trip13"
                     /note="ATPase domain of Pachytene checkpoint 2 (Pch2) and
                     similar ATPase domains; Region: RecA-like_Pch2-like;
                     cd19508"
                     /db_xref="CDD:410916"
     misc_feature    488..1084
                     /gene="Trip13"
                     /note="ATPase domain of Pachytene checkpoint 2 (Pch2) and
                     similar ATPase domains; Region: RecA-like_Pch2-like;
                     cd19508"
                     /db_xref="CDD:410916"
     misc_feature    order(527..529,578..583,590..595,611..622,626..640,
                     770..772,776..781,797..799,1058..1060)
                     /gene="Trip13"
                     /note="hexamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410916"
     misc_feature    order(527..529,578..583,590..595,611..622,626..640,
                     770..772,776..781,797..799,1058..1060)
                     /gene="Trip13"
                     /note="hexamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410916"
     misc_feature    order(665..667,677..685,758..760,764..769,881..886)
                     /gene="Trip13"
                     /note="ATP binding site [active]"
                     /db_xref="CDD:410916"
     misc_feature    order(665..667,677..685,758..760,764..769,881..886)
                     /gene="Trip13"
                     /note="ATP binding site [active]"
                     /db_xref="CDD:410916"
     exon            220..385
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            386..515
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            516..571
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            572..662
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            663..735
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            736..799
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            800..886
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            887..993
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1147
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1260
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1330
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1462
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1814
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatttgtcc gggactcggc cagggtggat cttcgtacag ctgagaagac tgtcccacag
       61 ggcgccgaga ggcgaccgcg acctcattct ggctggccgc atttcctcgg ctcccggctg
      121 cggcgccatg gacgacgcgg tgggcgacct gaagcaagcg cttccgtgtg ttgccgagtc
      181 gcccgcggtc catgtggagg ttttgcagcg cagcggaagc actgcaaaaa aagaagatat
      241 aaagcagagc gtttacaggc tgctcaagag gcataacatt gtgtttggag attacgtgtg
      301 gactgagttt gatgagcctt ttctaactag aaatgttcag tcggtatcta ttgttgacac
      361 agaattaaag gctaaagacc ctcagcccat tgatctgagt gcatgcacca ttgcacttca
      421 catcttccag ctgaatgaag aaggccccag cagtgaaaat ttggatgaag aaacagaaaa
      481 tataattgca gcaagtcact gggttttgcc tgcagctgaa tttcatgggc tttgggatag
      541 cctcgtgtat gatgtggagg tcaaatcaca tctccttgac tatgtgatga ccaccttact
      601 attctcagac aagaatgtgg acagcaacct tatcacctgg aaccgggtgg tactgctgca
      661 cggtcctccg ggtactggaa agacatccct ttgtaaggca ttagcccaga aactgaccat
      721 cagactgtca agcaggtacc ggtatggcca gttaattgaa ataaacagcc acagcctatt
      781 ttctaagtgg ttttcagaaa gtggcaagtt ggtaactaag atgttccaga agattcagga
      841 cttgattgat gataaagaag ctttggtgtt tgttctgatt gatgaggtgg agagtcttac
      901 agctgctcga aatgcttgca gggcaggcgc agagccatca gatgctatcc gtgtagtcaa
      961 tgctgtgttg actcagattg atcagattaa aaggcattcc aatgtggtga ttctgaccac
     1021 ttccaacatc actgagaaga ttgatgtggc ctttgtggat agagctgaca tcaaacaata
     1081 tattggcccc ccctctgcag cagccatctt caaaatctac ctgtcttgtt tagaagaact
     1141 gatgaagtgc cagatcatat atccccgtca gcagctgttg acccttcgag agctggaaat
     1201 gattggcttc attgaaaata atgtgtcgaa gttgagcctc cttttgagtg aaatttcaag
     1261 gaagagtgag ggcctcagcg gccgggtctt gaggaaactt cctttcctgg ctcatgcgct
     1321 gtatatccag gctcccagcg tcaccatcga gggtttcctc caggccctgt ctctggcagt
     1381 ggacaaacag tttgaggaga aaaagaaact ctcagctcat gtttgatccc agacatccat
     1441 atctgtggtt ttcaatggac aggccctgcc aagggattgc cacttgtgca aataccccgg
     1501 gagaaagggg attcctgtgc caatgtcctc ctacgtacag aggaatgaat gcaactgctg
     1561 ctaattccta tggagggaac acctgctaca gagagccaga gtgccctgtc tctatctgcc
     1621 ctgctggata ttctggaagg ttctgtaagt cggatcacac tgagtgtgct tccaacccct
     1681 accacaatgg ggtgctgtgc caggatggcg tcaataactg cacctgcttc tgtatgcctg
     1741 ggtaccaagg caggtgttgt gacttgaaaa ttgagtttaa gtctttaacc aaatctttca
     1801 gtgggtacac acaa
//
LOCUS       NM_001438318            3097 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 6, mRNA.
ACCESSION   NM_001438318 XM_063284704
VERSION     NM_001438318.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 3097)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 3097)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 3097)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063284704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1311007.1,
                                           SRR26643293.3958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  144815329-144815554 c
            227-401             JAXUCZ010000001.1  144794240-144794414 c
            402-590             JAXUCZ010000001.1  144734138-144734326 c
            591-814             JAXUCZ010000001.1  144723344-144723567 c
            815-1067            JAXUCZ010000001.1  144721538-144721790 c
            1068-1181           JAXUCZ010000001.1  144719060-144719173 c
            1182-1318           JAXUCZ010000001.1  144717593-144717729 c
            1319-1517           JAXUCZ010000001.1  144714015-144714213 c
            1518-1612           JAXUCZ010000001.1  144712661-144712755 c
            1613-1693           JAXUCZ010000001.1  144711957-144712037 c
            1694-3097           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3097
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..226
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1792
                     /gene="Cpeb1"
                     /note="isoform 6 is encoded by transcript variant 6; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 6"
                     /protein_id="NP_001425247.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MWPRGCLSAFLSRQGQEEESGRIKDCWDNQEVPALSTCSNANIF
                     RRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEEAITSRMLFPTSAQESPRGLPD
                     ANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSNTQSVLSMLQNPLGNVLGKTPLSFLSL
                     DPLGSDLDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRIS
                     PPLPFLSMTGNGPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGTSVWPSWDLL
                     GAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITE
                     GYVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSN
                     FVWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGR
                     VTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCF
                     KYFCRSCWHWRHSMEGLRHHSPLMRNQKN"
     misc_feature    227..1129
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    227..1129
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1133..1351
                     /gene="Cpeb1"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1133..1351
                     /gene="Cpeb1"
                     /note="RNA recognition motif (RRM) superfamily; Region:
                     RRM_SF; cl17169"
                     /db_xref="CDD:473069"
     misc_feature    1382..1633
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1382..1633
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1613..1780
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    1613..1780
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            227..401
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..590
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..814
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1067
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1181
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1318
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1517
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1612
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1693
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..3097
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgaggtc gcacgtgcgt gtgacggggc ttcgagggct gtccccggga gcctcgcggg
       61 tctgggggcg cgggcctgga ggtggagtca agcagcccgc gagggggcgc aggcgtggag
      121 cctgctagtc ctcggcggcg tccgctctcc tcggtcggcg gcctggcgag acgcactcat
      181 gtggcctcga ggctgtctct cagcttttct cagccggcaa ggccaggaag aagaatcagg
      241 aaggataaag gactgctggg acaaccaaga ggttcctgca ctctctacat gtagcaatgc
      301 caatatcttt cgaaggataa atgccatttt ggatgattca ctggacttca gtaaagtctg
      361 cacaacacct ataaatcgag gaattcatga tcagttgcca gacttccagg actctgaaga
      421 agcaattaca agcaggatgc ttttccccac ctctgcgcaa gaatctcccc gcggcctccc
      481 agatgcaaac ggtttgtgcc ttggcctgca gtcactcagt ctgactggct gggaccgacc
      541 ctggagcacc caggactcag actcctcagc ccagagcaac acacagtcag tattaagcat
      601 gctccaaaat ccactgggaa atgtcttagg aaaaaccccc ttgagcttcc tgtctctgga
      661 tccccttggg tctgacttgg acaagttccc agcgccctca gttagaggat ctcgcctgga
      721 cacccggcct atcctggact cccgttctag cagcccctct gactcagaca cgagtggctt
      781 cagctctgga tcagatcatc tctcagattt gatttcaagc cttcgcattt cccctcctct
      841 gccctttctt tctatgacgg gaaatggtcc cagagaccct ctaaagatgg gagttgggtc
      901 tcgaatggac caagagcaag ctgctcttgc tgcagttgct ccctctccaa ccagtgctcc
      961 aaagagatgg ccaggaactt ctgtgtggcc atcttgggac cttctcggag ctcctaaaga
     1021 cccattcagc atagagagag aggctagact ccacaggcag gccgcagctg tgaatgaagc
     1081 tacatgtacc tggagtggcc agcttcctcc ccggaactac aagaacccca tctactcatg
     1141 caaggtgttc ctaggaggtg ttccttggga cattacagaa gggtatgtgt atttggtgtt
     1201 tgaactagag aagtccgtcc gggccttgct tcaggcttgt tctcatgacc cactgagccc
     1261 agatggccta agtgaatatt atttcaagat gtccagccga aggatgcgct gcaaagaagt
     1321 acaggtaatc ccttgggtct tggctgacag caactttgtc tggagcccat ctcagaggct
     1381 ggatcccagc aggacggtgt ttgttggtgc cttgcacggg atgctcaatg ctgaggctct
     1441 ggctgccatc ttgaatgacc tatttggtgg agtggtgtat gctgggattg acacagataa
     1501 gcacaagtac cccattgggt ctggtcgtgt gactttcaat aaccaacgta gttacctgaa
     1561 agcagtcact gctgcttttg tggagatcaa aaccaccaag tttaccaaga aggttcagat
     1621 cgacccctat ctagaagatt ctctgtgtct tatctgcagt tcacaacctg gtcctttctt
     1681 ctgccgagat caggtctgct tcaagtactt ttgccgaagc tgctggcact ggcgacacag
     1741 catggaaggc ctacgccacc acagcccgct aatgaggaac cagaagaact aaaattccag
     1801 ctagagaagc tggcctggcc cagggcctgt ggcgccaaag gctggcaagt caggcagcag
     1861 cctgttccct gcacgggcgc ctaggagcta gctttctgca gacaagggag aattgtactc
     1921 acctttgtac ttgctgagtc tgtctttgtt tctgcactaa ttaatgcaca atgagttttg
     1981 tcaggttttg tcttcagcgg ggtgtgccag agcaggggcc tcaggctcac cctcaagcaa
     2041 ttgtagtttt cccagattct agttcctcat tttgcaaatg aaaacaacaa aaaaaactgt
     2101 gtctagaacg cgttgacaca gatgcctaca cttgggttta tttattaaag cgcttcttac
     2161 attccttgca atactgatgg tggtgatgcg caggtctcat tggtccattc ttgcagttgc
     2221 catacagtgc ctttccattt atttaacccc cacctgaacg gcataaattg agtgttcagc
     2281 tggtgttttt tactgtaaca aacaaaggag actttgctct tcatttaaac caaatcatat
     2341 ttcatagttt acgctcgagg gtttttactg gttccttttt acactcctta aaacagtttt
     2401 taagtcgttt ggaacaatag attttttttt cttttttggc agcttttaac attatagcaa
     2461 atttgtgtct gggggactgc tggtcacagt tgcaaatcaa agcatttgta accaagagaa
     2521 aaattatttt atttaaaact ggatgggagg aaaaattagg tctgagcagc tgctgtatat
     2581 agttttaaat ggtttgtcgc accttatgtt gcacttacgt tgggggaggg ttgatagaag
     2641 tttttaatca cagtcacagg actttttctt ttgtaactga gcttaaaaat taaaaaaaaa
     2701 aaaagggctg ctttttggtg ggggcggatg aaggctcaca ggagcccttt ctcttagagg
     2761 ggcaagtacc cttccttaca acttttattt gaagaatgta tgaatcaaca gttattgttg
     2821 acaaaaatgt tactggaatt gaaaacttga ctcttttttt aaaaatttag ttactacttg
     2881 cccctcttag ggaagctgtg tgccaaagaa ccagtgtcgc ccccctgctg agctgacgtt
     2941 gcattgtcgc atatcccagc tactctgtgg gctcgtgaag ctgtgtgtga agtctctacc
     3001 tcattgttgt acatgcaggc aagactgcac tctgtacaga ttgtggagta agctgtggtg
     3061 tacttttttt ggcacataat aaacacgttg cagcaga
//
LOCUS       NM_001438304            3045 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 220 (Rnf220), transcript
            variant 3, mRNA.
ACCESSION   NM_001438304 XM_017593798
VERSION     NM_001438304.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3045)
  AUTHORS   Ma,P., Yang,X., Kong,Q., Li,C., Yang,S., Li,Y. and Mao,B.
  TITLE     The ubiquitin ligase RNF220 enhances canonical Wnt signaling
            through USP7-mediated deubiquitination of beta-catenin
  JOURNAL   Mol Cell Biol 34 (23), 4355-4366 (2014)
   PUBMED   25266658
REFERENCE   2  (bases 1 to 3045)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced XM_017593798.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.19820.1,
                                           SRR26643298.28542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JAXUCZ010000005.1  136197677-136198022 c
            347-1088            JAXUCZ010000005.1  136190568-136191309 c
            1089-1221           JAXUCZ010000005.1  136012745-136012877 c
            1222-1267           JAXUCZ010000005.1  136004531-136004576 c
            1268-1369           JAXUCZ010000005.1  136000843-136000944 c
            1370-1412           JAXUCZ010000005.1  135993033-135993075 c
            1413-1456           JAXUCZ010000005.1  135989948-135989991 c
            1457-1589           JAXUCZ010000005.1  135989404-135989536 c
            1590-1686           JAXUCZ010000005.1  135981970-135982066 c
            1687-1773           JAXUCZ010000005.1  135981716-135981802 c
            1774-1829           JAXUCZ010000005.1  135981554-135981609 c
            1830-1908           JAXUCZ010000005.1  135981364-135981442 c
            1909-2017           JAXUCZ010000005.1  135977575-135977683 c
            2018-2092           JAXUCZ010000005.1  135977386-135977460 c
            2093-3045           JAXUCZ010000005.1  135975738-135976690 c
FEATURES             Location/Qualifiers
     source          1..3045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3045
                     /gene="Rnf220"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
     exon            1..346
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1088
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    437..439
                     /gene="Rnf220"
                     /note="upstream in-frame stop codon"
     CDS             464..2164
                     /gene="Rnf220"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase RNF220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF220 isoform 2"
                     /protein_id="NP_001425233.1"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
                     /translation="MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQ
                     PRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPP
                     NLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDSESPHLRFSDADG
                     KEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFD
                     SQAPICPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASI
                     KREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREG
                     SCVAEDDAVDIEHENSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDA
                     DLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFS
                     KWASDEMPSTSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEALKARVRELERQLSR
                     GDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL
                     "
     misc_feature    1112..1795
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    1112..1795
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    1997..2152
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     misc_feature    1997..2152
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     exon            1089..1221
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1267
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1369
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1412
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1456
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1589
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1686
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1773
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1829
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1908
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2017
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2092
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..3045
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgtgcat gtgtgtgtga gtgtgtgtgc gcgcgcgcgt gtgtgtgcgc ctccgagtcc
       61 ctgggagagt ggaggctcat tcactgatta gagccagcgc tgagaggcag cactgctctt
      121 ctctcacacc aaccgagtct cttgatctgt acatgcaatc ccaggcagct cgcgagcaca
      181 aacccggggc cagccgcctg ctgctgctgc tgctgccgct gccgccgcca ccgccgccgc
      241 tgcccccgcc ggctctgcgc acccgggact tttcatgcac cacactctcc gtcttcttac
      301 ctcggtgtcc tgaaaagtgc gaccgttctc ccctggaatt tccacggtct tcggagggca
      361 tgattcccca gtaataatcc tcgccctgat ccaaggtgca ggttggcctc cctcccaggg
      421 aagactgctt cttgcgtgac acccgccatc gaaagagact ccaatggact tacaccgggc
      481 agccttcaag atggagaact catcctatct tcccaaccct ctggcatccc cggcactgat
      541 ggtcctggcg tccactgccg aggccagcag ggatgcctcc atcccgtgtc agcagccacg
      601 accctttggt gtacctgtct cagtagacaa agacgttcat attcccttca ccaatggctc
      661 ttacaccttt gcctctatgt accaccgtca aggtggggtg ccgggcactt ttgccaatcg
      721 tgatttcccc ccttccttac tacacctcca cccccagttt gcccccccaa atctagattg
      781 caccccaatc agtatgctaa atcacagtgg cgtgggggca ttccgtccct tcgcttccac
      841 ggaggacagg gagagctatc agtcagcctt tacgccagcc aagagactca agaactgtca
      901 cgactcagag tctccccacc tgcgcttctc agatgcagat ggcaaggaat atgactttgg
      961 gacacagctg ccgtccagct cccctggttc acttaaggtt gatgatactg ggaagaagat
     1021 ctttgccgtg tctggcctca tctctgaccg ggaaacctcc tcgagtccag aggatcggaa
     1081 tgacagatgt aagaagaaag cagtagcgtt gtttgacagc caagccccga tctgccccat
     1141 ctgccaagtc ctgctgaggc ccagcgagtt gcaggaacat atggagcaag aactggagca
     1201 gctggcccaa ctgcctgcca gcaaaaattc ccttctgaag gatgccatgg ctccgggcac
     1261 ccccaagtcc ctcctgttgt ctgcttccat caagagggaa ggagactctc caaccgcttc
     1321 cccacactcc tctgccaccg aggacctgca ccactcagac agataccaga ccttcttgcg
     1381 agtgcgagcc aaccggcaaa cccgactgaa tgctcggatt gggaaaatga aacggaggaa
     1441 gcaagatgaa gggcagaggg aaggctcctg cgtggctgag gatgacgccg tggacatcga
     1501 gcatgagaac agcaaccgct ttgaggagta tgagtggtgt gggcagaagc ggatacgggc
     1561 caccacgctc ctggaaggtg gcttccgagg ctccggcttc gttatgtgca gtggtaaaga
     1621 gaatccagac agtgatgctg acctggatgt ggatggagat gacactctgg agtatgggaa
     1681 accacaatac acagaggctg atgtcatccc atgcacagga gaagagcctg gtgaagccaa
     1741 ggagagagag gcactccggg gcgcagtcct aaatggtggc cccccgagca cccgcatcac
     1801 acctgagttc tctaaatggg ccagtgatga gatgccgtcc accagcaatg gtgaaagcag
     1861 caagcaggaa gccatgcaga agacctgcaa gaacagtgac attgagaaaa tcaccgaaga
     1921 ttcagctgta actacctttg aggctctaaa ggctcgggtc agggagcttg aacggcagct
     1981 atctcggggt gaccgataca aatgcctcat ctgcatggac tcatactcaa tgccgctgac
     2041 gtcgatccag tgttggcatg tgcactgtga agagtgttgg cttcggactc tgggtgccaa
     2101 gaagctctgc cctcagtgca acaccatcac agcccctgga gacctgcgga ggatctactt
     2161 atgagctagc tgtccaggca ggccctgcct cgagcaaacc cctgctccag cctctgtgac
     2221 agtgaccgcc cctcccccct tgtacatact tgcacacagg tcccccgtgt acatacatgc
     2281 atatacacac ccaaacacac atagaggact ctggagccag agtggaacag ccctgcctgc
     2341 ttgttccttc tgaacttggg gaccatgcct ctttggactc tgtttccagg gttggcagga
     2401 aggtggtttg ggaagtatag caggacgagg ctcctgagat ccatccccga gactgactga
     2461 cagacacgca aacaccagac tgaagcacat gtaatataga ctgtgtatgt ttacaatgtt
     2521 gtgtataaat gggacacttt gccctctacc accttcccct ttgggtgtat gattttcttc
     2581 ttttataatg actcctggaa gcagtgcccc ttcagggctg gctgggggct cggcccaacc
     2641 acctcttagg gtgcctgcct cttcctctcc catggcatcc cttcccttcc ccatgtgctc
     2701 agtgttcagt ggtgtatatt tcttctccca aacacggggc gtgtgccccg aggggtctga
     2761 tcctctcctt agtcttagct catggggctc ctcatgagga gctgggggta gggtggaatg
     2821 ggaccaagca ggaacaggct gcaggctggc tggctgaggg tgcctggctg cccagcctgc
     2881 tgttgagaac cacccctggg gtagacactg ctcccagggg aagtgctggc cccgcccctg
     2941 tgtgggccct gtggtgtgat gctgtgtctg tatattctat acaaaggtac ttgtcctttc
     3001 cctttgtaaa ctacatttga catggattaa aacagtataa accag
//
LOCUS       NM_001438257            4847 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 1, mRNA.
ACCESSION   NM_001438257 XM_063282787
VERSION     NM_001438257.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4847)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 4847)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 4847)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 4847)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 4847)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 4847)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 4847)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 4847)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.437702.1,
                                           SRR26643293.9500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  265880949-265881004
            57-389              JAXUCZ010000001.1  265885603-265885935
            390-445             JAXUCZ010000001.1  265888925-265888980
            446-590             JAXUCZ010000001.1  265892382-265892526
            591-696             JAXUCZ010000001.1  265893680-265893785
            697-760             JAXUCZ010000001.1  265896331-265896394
            761-865             JAXUCZ010000001.1  265897265-265897369
            866-1048            JAXUCZ010000001.1  265897587-265897769
            1049-1192           JAXUCZ010000001.1  265898203-265898346
            1193-1364           JAXUCZ010000001.1  265898771-265898942
            1365-1451           JAXUCZ010000001.1  265899871-265899957
            1452-1619           JAXUCZ010000001.1  265902762-265902929
            1620-1727           JAXUCZ010000001.1  265903044-265903151
            1728-1898           JAXUCZ010000001.1  265903930-265904100
            1899-2141           JAXUCZ010000001.1  265905270-265905512
            2142-2279           JAXUCZ010000001.1  265905824-265905961
            2280-2390           JAXUCZ010000001.1  265908907-265909017
            2391-2561           JAXUCZ010000001.1  265909555-265909725
            2562-2834           JAXUCZ010000001.1  265912578-265912850
            2835-2954           JAXUCZ010000001.1  265914596-265914715
            2955-3071           JAXUCZ010000001.1  265915981-265916097
            3072-3239           JAXUCZ010000001.1  265918673-265918840
            3240-3467           JAXUCZ010000001.1  265920045-265920272
            3468-3514           JAXUCZ010000001.1  265920791-265920837
            3515-3607           JAXUCZ010000001.1  265920914-265921006
            3608-4847           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..4847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4847
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..56
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..389
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             86..3607
                     /gene="Tdrd1"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 1"
                     /protein_id="NP_001425186.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSR
                     VQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNV
                     HAVSVEKCSENGMINIAENLVMCGLAENLSSKRESASTKETPHSTDCCCTELQKQIEK
                     HEQILLFLLNNPTNQNKFIEMKKLLQS"
     misc_feature    569..679
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    569..679
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    866..1255
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    866..1255
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1034..1036,1055..1057,1109..1111,1118..1120,
                     1124..1126)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1034..1036,1055..1057,1109..1111,1118..1120,
                     1124..1126)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1616..1861
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1616..1861
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1721..1723,1742..1744,1793..1795,1802..1804,
                     1808..1810)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1721..1723,1742..1744,1793..1795,1802..1804,
                     1808..1810)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2207..2557
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2207..2557
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2894..3241
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    2894..3241
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    order(3065..3067,3080..3082,3086..3088,3134..3136,
                     3143..3145,3149..3151)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     misc_feature    order(3065..3067,3080..3082,3086..3088,3134..3136,
                     3143..3145,3149..3151)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     exon            390..445
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..590
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..696
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..760
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..865
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1048
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1364
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1451
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1619
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1727
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1898
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2141
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2279
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2390
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2561
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2834
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2954
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3071
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3239
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3467
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3514
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3607
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..4847
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcgca ggcgcgggat caacagcacg cggcagcctt gagcgtccga ggcgagacgt
       61 cagtgaatgt taagttacat ctaatatgat gccacgaaat aatttggaag cctctacttg
      121 taaaatggca gaaccattta attttgagaa aaaggaaagc aaacttccac cccacgattc
      181 tctaagaagt cctgtaccac agcataacca tcccaatttc agactgaaaa gcccagagaa
      241 cggaaataaa aagaacaatt ttttgctttg tgaacaaaac aaacagtact tggctagtca
      301 ggaagacaat tcggtggtct cttcaaaccc tgctggtatc aatggagaag taggtgggtc
      361 caaaggagac aggaagacat taccaacagg aaacccagta tcattaagtc ttggaaacaa
      421 ttcaccacct aaccaagtaa aaactaagcc cagcaatgct gtgactcctg aaaaatcaaa
      481 aaaatctcac aagctgtttg agaatgcctt gtccgtaaat aacccagctc tcttcaactc
      541 gttaggaccg cccctgcggt ccacaacctg ccatcgctgt ggcctgttcg ggtcgctgag
      601 gtgttcccag tgcaagcaga catattactg ctccacagca tgccagagga gagactggtc
      661 ttcccatagc accatctgta gacctgtgca gcaaagtctg cataagcttg aagataataa
      721 gtcaccattt gaaacaaaga ccattgacgt gaagaatgag gttgcctgtc ccctgggagt
      781 tactaaagaa atgacagctg gtgcagagag agtaatgttt tctgatctga ggagtctcca
      841 actgaggaaa tccatggaaa taaagggcac agttactgaa ttcaagcacc cgggtcattt
      901 ttatgtccag ttgtattcct cagaggtttt agagtacatg aaccaactct ctgcaagttt
      961 gaaagagaca tatgcaaata tggtgcctga agacggatat cttcctgtta agggggaagt
     1021 ctgtgttgcc aagtacacgg ttgatcagac ctggaaccga gccgtagtag aaggcgtgga
     1081 cgtgctgcag aagaaggcac atgtcttgta catcgactac ggaaatgaag agatcatccc
     1141 agtcgacaga atccaccagc taagcagaag tatcagcctg tttccccctt ccgccataaa
     1201 gtgctatgtg tcaggagtcg tccccgctgc gggtgagtgg actgaagact gtgttgtagc
     1261 tgtcaaggct ctgctgttcg agcagtactg ctctatcaag gtcgtggaca tctcagagga
     1321 ggaggggctc acctgtgctg tcgacgtcgt gctgcagagt tcaggaaaac agctggacca
     1381 tgtgcttgtg gaaatgggat atggtgtgaa acctgatgag ccgagctcca agaagcaaag
     1441 tatggaccca ggcacttcgg aggacactgg aagactgaca gctgagaaca ggatcggggc
     1501 agagagaaat gccctggtcc ccacagtgct gactttgaat gtgggtgacg agttctgtgg
     1561 tgtagttgcc cacatccaga caccagagga cttcttttgt cagcagctgc agagtggcca
     1621 caagctcgcc gagcttcagg agtccctcag tgagtactgt agccacgtga ctccacgctc
     1681 agacttttat ccaaccattg gggacatgtg ttgtgctcag ttctcagagg atgaccaatg
     1741 gtaccgcgcc tcggttctgg cctatgcttc agaagaatct gtcctggttg gatatgtcga
     1801 ttatggaaac tttgaaattc ttagtttgaa aagactttgt cccataattc caaagttgtt
     1861 ggatttgccg atgcaagctt taaattgtgt gctggcagga gtgaagccat ctttaggaat
     1921 gtggactcca gaagccattt gtgtcatgag gaaggctgtg cagaacagga tggtgaccgt
     1981 gagagtggtg ggcatgcagg ggaccagggc cctggtggag ctcgtagaca aatcggtggc
     2041 tcctcacctc agcgcttcta aagctctgct agactccggc tttgccatcg aggaaaagga
     2101 catagtggca gataaaggca gcagtgcgcg tgcctcgaat gttcccttgg ctgtagaagg
     2161 agcagtggag gtgctggagt ggacgtgggt cgagttcacc gttgacgaga ctgtggacgt
     2221 gatggtctgc atgatgcaca gccctgggga gttctactgc cactgtctca aagacgacgc
     2281 cttaaagaag ctcgatgact tgaacaagtc cttagcagac tactgtgcac aaaaaccgcc
     2341 caatggcttc aaggcagagg tagggcggcc ttgctgtgcc tgttttgcag gtgacggcaa
     2401 ctggtaccgg gctctggtca aggagatcct accaagtggg aacgtcaaag tacactttgt
     2461 ggactacggc aatgttgaag aggttaccac agaccaactg cacgcaatag ccccccagtt
     2521 cttactactt ccgttccaag ggatgcagtg ctggctagta gatatacagc ccaaaaacaa
     2581 gcattggaca aaagaagcca cagcaagatt tcaagcatgt gtcgtggggc ttaaacttca
     2641 agccagagtt gtggaaatca cggagaatgg ggtgggcgtt gaactcaccg atctttccac
     2701 cccctacccc aaaatcatta gtgacgttct catcacagaa catctggtct taaggtgtgg
     2761 ttcaccacag aaggacgagt tgatgagcag acctgctaat aaacataacc agatcgactc
     2821 ccagagcgtg caagccagcc ctcctgcaga gcagtggaag accatagagt tgccagttaa
     2881 caagactgta ccagcaaatg tactagaaat cataagccca accttgtttt atgccatccc
     2941 cagtgaaatg ccagaaaatc aagaaaaact gtgtgtgttg acagctgaat tgttagaaca
     3001 ctgtaacgct cagaaaggcc agccacccta cagaccacgg acgggagaag cctgctgtgc
     3061 taaatacaca aatgatgact tctggtaccg ggccattgtt ctggaagcgt cagactctga
     3121 tgtgaaagtt ctctatgcag attatggaaa cgtggaaaga ctgccttttt ccagagtgca
     3181 gcccatcact gccagccacc tgcagctgcc cttccgcatc attagatgct cacttgaggg
     3241 gctgacggag ctgaacggaa gcagttcgca gccagtgatg gagctgctga ggaacgccat
     3301 gctgaaccag agtgtggctc tctctgtgaa agcagtctcg aagaatgtcc atgcagtgtc
     3361 agttgaaaaa tgttctgaaa atggaatgat caatatagct gagaatctgg tgatgtgtgg
     3421 cctggcagaa aacctctcat ctaaaaggga aagtgcttca actaaagaaa caccgcacag
     3481 caccgattgc tgctgcacag agttacagaa acagattgag aaacacgaac agattctcct
     3541 cttcctctta aacaatccaa ccaaccaaaa taaatttata gagatgaaaa agctgctgca
     3601 aagctaaaaa catcatccct ggggaaaaac actcgggaag aaggagacca caaaagccag
     3661 actagagaaa gaattgtatc ttgtgtttgt tcgctggaac tgttgcttcc tctcctttcc
     3721 ttagtgacct ttgacctcac cacccctact tacttacctt gttctgttgg gtttgttgcc
     3781 ctctccctga ttctttccac aaaatacatg aatcttgcat aagaggttca tgtactagct
     3841 aggcgtggtg gtgcacacct gtaatcccag ccatgagcag aatgaggcaa gaagacctca
     3901 agttcaaggc cagcatgggc tacatagata gtttctcatt acaaacaaaa ccaaacatca
     3961 agattcaaaa aatgtatgag acgactagga aggaacatga ggtatcttct actaagagtg
     4021 cgtgcatgag tgcgcgtatg cgtgtgtgtg tgtgtgtatt tgctctactg agtatagaag
     4081 ctagagcctc ccgtgtgtta ggcaagcttt ccctctgagc tacagtccca gctctagcat
     4141 ctcgctgtcc ttgaaaggct gggtggctgc cctgggcggg cgggcttcag catggtctga
     4201 acatcacagg cctctgctaa tgagatgctc ttggtcatct gccgcctcgt cccctgctgg
     4261 gatctgattg gttctttgct tctgggtgcc atgcttcctt tgtgacttgt ggccaaggat
     4321 gtgtgctgct gctctcatct gtgctgagac agcttggctt ttcatcttcg atcacagctt
     4381 cagtcttggc actaggagga cactttctgc ccctgccctc agaggccctc ctgggattgt
     4441 ctcactagtc tgtagtcatt cagacttaag ctctagaaat aattcactat tttctcaaac
     4501 acaaactcca gatatcgatt taaaaatgga gagcacattt gtcatagttc atgatcacag
     4561 attgtcccaa ccttagccat gggcagcagt gtgtgccttc ctgacagtcc catagtcgct
     4621 ctggcaattg tcccacggtt tcagtgctgt gcggcactgt gacaacttaa tacaacatcc
     4681 ccagcactga tattgatgtg ggtgggtttg ttccatttcc ttttactggc aatgtgtgtc
     4741 agctcttctg ttaaatagga cttctcacgt aaacagttgc ttgaatgttg atgtgcctca
     4801 aacagctaag tttgtcctga ttcatccagt aaactcactt gtcttca
//
LOCUS       NM_001438305            1924 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 220 (Rnf220), transcript
            variant 5, mRNA.
ACCESSION   NM_001438305 XM_008764079
VERSION     NM_001438305.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Ma,P., Yang,X., Kong,Q., Li,C., Yang,S., Li,Y. and Mao,B.
  TITLE     The ubiquitin ligase RNF220 enhances canonical Wnt signaling
            through USP7-mediated deubiquitination of beta-catenin
  JOURNAL   Mol Cell Biol 34 (23), 4355-4366 (2014)
   PUBMED   25266658
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced XM_008764079.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29546.1,
                                           SRR26643298.28544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000005.1  135993211-135993458 c
            249-291             JAXUCZ010000005.1  135993033-135993075 c
            292-335             JAXUCZ010000005.1  135989948-135989991 c
            336-468             JAXUCZ010000005.1  135989404-135989536 c
            469-565             JAXUCZ010000005.1  135981970-135982066 c
            566-652             JAXUCZ010000005.1  135981716-135981802 c
            653-708             JAXUCZ010000005.1  135981554-135981609 c
            709-787             JAXUCZ010000005.1  135981364-135981442 c
            788-896             JAXUCZ010000005.1  135977575-135977683 c
            897-971             JAXUCZ010000005.1  135977386-135977460 c
            972-1924            JAXUCZ010000005.1  135975738-135976690 c
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1924
                     /gene="Rnf220"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
     exon            1..248
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Rnf220"
                     /note="upstream in-frame stop codon"
     CDS             195..1043
                     /gene="Rnf220"
                     /EC_number="2.3.2.27"
                     /note="isoform 4 is encoded by transcript variant 5; E3
                     ubiquitin-protein ligase RNF220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF220 isoform 4"
                     /protein_id="NP_001425234.1"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
                     /translation="MPRARSGRRSREAGGREETFLRVRANRQTRLNARIGKMKRRKQD
                     EGQREGSCVAEDDAVDIEHENSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKE
                     NPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTR
                     ITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEALKARVREL
                     ERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGD
                     LRRIYL"
     misc_feature    <237..674
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    <237..674
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    876..1031
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     misc_feature    876..1031
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     exon            249..291
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            292..335
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            336..468
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            469..565
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            566..652
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            653..708
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            709..787
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            788..896
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            897..971
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1924
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgatcaa ggccaacatg gccgccgccg ctgctgggag ctgaagtgcc gccgccgccg
       61 ggcagccggg gggaatccgc cggcatcgcc gcccttgccg gccgggctgc tacggggccc
      121 agagcgccgg aagctggggc tggggcggca ccgcgcggcg gcctcgggct cccgttagag
      181 cagcccgggc ggctatgccg agggcccgga gcggccggcg gagcagggag gccggcggga
      241 gggaggaaac cttcttgcga gtgcgagcca accggcaaac ccgactgaat gctcggattg
      301 ggaaaatgaa acggaggaag caagatgaag ggcagaggga aggctcctgc gtggctgagg
      361 atgacgccgt ggacatcgag catgagaaca gcaaccgctt tgaggagtat gagtggtgtg
      421 ggcagaagcg gatacgggcc accacgctcc tggaaggtgg cttccgaggc tccggcttcg
      481 ttatgtgcag tggtaaagag aatccagaca gtgatgctga cctggatgtg gatggagatg
      541 acactctgga gtatgggaaa ccacaataca cagaggctga tgtcatccca tgcacaggag
      601 aagagcctgg tgaagccaag gagagagagg cactccgggg cgcagtccta aatggtggcc
      661 ccccgagcac ccgcatcaca cctgagttct ctaaatgggc cagtgatgag atgccgtcca
      721 ccagcaatgg tgaaagcagc aagcaggaag ccatgcagaa gacctgcaag aacagtgaca
      781 ttgagaaaat caccgaagat tcagctgtaa ctacctttga ggctctaaag gctcgggtca
      841 gggagcttga acggcagcta tctcggggtg accgatacaa atgcctcatc tgcatggact
      901 catactcaat gccgctgacg tcgatccagt gttggcatgt gcactgtgaa gagtgttggc
      961 ttcggactct gggtgccaag aagctctgcc ctcagtgcaa caccatcaca gcccctggag
     1021 acctgcggag gatctactta tgagctagct gtccaggcag gccctgcctc gagcaaaccc
     1081 ctgctccagc ctctgtgaca gtgaccgccc ctcccccctt gtacatactt gcacacaggt
     1141 cccccgtgta catacatgca tatacacacc caaacacaca tagaggactc tggagccaga
     1201 gtggaacagc cctgcctgct tgttccttct gaacttgggg accatgcctc tttggactct
     1261 gtttccaggg ttggcaggaa ggtggtttgg gaagtatagc aggacgaggc tcctgagatc
     1321 catccccgag actgactgac agacacgcaa acaccagact gaagcacatg taatatagac
     1381 tgtgtatgtt tacaatgttg tgtataaatg ggacactttg ccctctacca ccttcccctt
     1441 tgggtgtatg attttcttct tttataatga ctcctggaag cagtgcccct tcagggctgg
     1501 ctgggggctc ggcccaacca cctcttaggg tgcctgcctc ttcctctccc atggcatccc
     1561 ttcccttccc catgtgctca gtgttcagtg gtgtatattt cttctcccaa acacggggcg
     1621 tgtgccccga ggggtctgat cctctcctta gtcttagctc atggggctcc tcatgaggag
     1681 ctgggggtag ggtggaatgg gaccaagcag gaacaggctg caggctggct ggctgagggt
     1741 gcctggctgc ccagcctgct gttgagaacc acccctgggg tagacactgc tcccagggga
     1801 agtgctggcc ccgcccctgt gtgggccctg tggtgtgatg ctgtgtctgt atattctata
     1861 caaaggtact tgtcctttcc ctttgtaaac tacatttgac atggattaaa acagtataaa
     1921 ccag
//
LOCUS       NM_001438267            4281 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 418 (Zfp418), transcript
            variant 3, mRNA.
ACCESSION   NM_001438267
VERSION     NM_001438267.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4281)
  AUTHORS   Singh,S.R., Meyer-Jens,M., Alizoti,E., Bacon,W.C., Davis,G.,
            Osinska,H., Gulick,J., Reischmann-Dusener,S., Orthey,E.,
            McLendon,P.M., Molkentin,J.D., Schlossarek,S., Robbins,J. and
            Carrier,L.
  TITLE     A high-throughput screening identifies ZNF418 as a novel regulator
            of the ubiquitin-proteasome system and autophagy-lysosomal pathway
  JOURNAL   Autophagy 17 (10), 3124-3139 (2021)
   PUBMED   33249983
REFERENCE   2  (bases 1 to 4281)
  AUTHORS   Pan,L., Sheng,M., Huang,Z., Zhu,Z., Xu,C., Teng,L., He,L., Gu,C.,
            Yi,C. and Li,J.
  TITLE     Zinc-finger protein 418 overexpression protects against cardiac
            hypertrophy and fibrosis
  JOURNAL   PLoS One 12 (10), e0186635 (2017)
   PUBMED   29065170
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212491.1, SRR26360194.1229427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000001.1  75614540-75614743
            205-243             JAXUCZ010000001.1  75615306-75615344
            244-328             JAXUCZ010000001.1  75617931-75618015
            329-4281            JAXUCZ010000001.1  75623415-75627367
FEATURES             Location/Qualifiers
     source          1..4281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..4281
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="zinc finger protein 418"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
     exon            1..204
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream in-frame stop codon"
     misc_feature    109..111
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MKAKKTVGSSGSCVRAPALSTEP"
     CDS             178..2118
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 418 isoform 3"
                     /protein_id="NP_001425196.1"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
                     /translation="MAAVKHLAQIPRCTETGMICTQEEWKLLDEAQRLLYLDVMLENF
                     TLISSLVYRYEAEAEEKTCAQSLSQTEAPQVRTPKQGQLRQKPHPSDICITVLKDILH
                     LNDLPGQKPYLTEVCTKPQDHKHHRAKNWLKRDVDSLVKSCIFHVAGNPFICSKIGEK
                     FPAIWNLLQPKDIPNGEKQNKIKRGKAFHRDKNNSESDEYKKSSSPQHRLHEYPGVCS
                     AKGGFESNSCEQDLNKYSPAPFRMDQTENRPYECHVCGKWFGQKATLRIHQRRHTGEK
                     PYKCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWPY
                     ECSDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHC
                     EACGKSFSQSANLIKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECRE
                     CGKFFKQYFYLIEHRRIHTTTEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEECG
                     KAFEYKSRLKRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKPYHCDQCGKC
                     FSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSFS
                     QVSTLTRHQLLHTGEKPYKCSK"
     misc_feature    <238..327
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    <238..327
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    931..993
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    931..993
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(946..948,952..954,958..960,964..969,976..981,
                     988..990,1030..1032,1036..1038,1048..1053,1060..1065,
                     1072..1074,1114..1116,1120..1122,1126..1128,1132..1137,
                     1144..1149,1156..1158)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(946..948,952..954,958..960,964..969,976..981,
                     988..990,1030..1032,1036..1038,1048..1053,1060..1065,
                     1072..1074,1114..1116,1120..1122,1126..1128,1132..1137,
                     1144..1149,1156..1158)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1003..2076
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1003..2076
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1015..1077
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1015..1077
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1099..1161
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1099..1161
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1183..1245
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1183..1245
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1267..1329
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1267..1329
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1282..1284,1288..1290,1294..1296,1300..1305,
                     1312..1317,1324..1326,1366..1368,1372..1374,1384..1389,
                     1396..1401,1408..1410,1450..1452,1456..1458,1462..1464,
                     1468..1473,1480..1485,1492..1494)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1282..1284,1288..1290,1294..1296,1300..1305,
                     1312..1317,1324..1326,1366..1368,1372..1374,1384..1389,
                     1396..1401,1408..1410,1450..1452,1456..1458,1462..1464,
                     1468..1473,1480..1485,1492..1494)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1351..1413
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1351..1413
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1435..1497
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1435..1497
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1519..1581
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1519..1581
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1603..1665
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1603..1665
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1687..1749
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1687..1749
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1771..1833
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1771..1833
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1855..1917
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1855..1917
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1870..1872,1876..1878,1882..1884,1888..1893,
                     1900..1905,1912..1914,1954..1956,1960..1962,1972..1977,
                     1984..1989,1996..1998,2038..2040,2044..2046,2050..2052,
                     2056..2061,2068..2073,2080..2082)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1870..1872,1876..1878,1882..1884,1888..1893,
                     1900..1905,1912..1914,1954..1956,1960..1962,1972..1977,
                     1984..1989,1996..1998,2038..2040,2044..2046,2050..2052,
                     2056..2061,2068..2073,2080..2082)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1939..2001
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1939..2001
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2023..2085
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2023..2085
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            205..243
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            244..328
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            329..4281
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcgtc ctgtctttgg tttaacttcc catgggttgg tatttggagg attctgagct
       61 ttaggatcgc caaattatac tcaagttaag agagagagcc ggcgcaggat gaaggccaag
      121 aagaccgtag gcagcagcgg tagctgtgtc cgggcccctg cgttgtcaac agagccgatg
      181 gcggctgtga agcacctggc tcagattccc agatgtacag aaacgggtat gatctgtaca
      241 caggaagagt ggaagctcct ggatgaagct cagaggctac tgtatcttga tgtgatgctg
      301 gagaatttta cccttatatc ctcactggtt tatcggtatg aagcagaggc tgaagaaaaa
      361 acctgtgcac agagtctttc acaaactgaa gcaccacaag tcaggactcc gaagcaaggt
      421 caactcaggc agaagcctca tccctctgac atctgtatca ccgtcctgaa agatatcttg
      481 catctgaacg acctacctgg gcaaaagccg tatttgaccg aagtgtgtac aaagccccag
      541 gaccataagc atcacagagc caagaattgg ttaaagagag acgtggactc ccttgtgaag
      601 agctgtatat tccatgtggc agggaaccct ttcatctgta gtaagattgg agagaaattc
      661 ccagctatat ggaatcttct ccaacccaag gacatcccca acggtgagaa acaaaataaa
      721 attaagcgtg gaaaggcttt tcacagggat aaaaataatt ctgaatcaga tgaatataag
      781 aaatcttcca gcccccaaca caggcttcat gaatacccag gagtttgcag tgcaaagggg
      841 ggttttgaat ctaacagttg tgagcaagac ttaaacaagt actcacctgc accattccgg
      901 atggaccaga ctgaaaaccg accatatgag tgtcatgtct gtggaaaatg gtttggccag
      961 aaagccacac ttagaataca ccagagacgt cataccggag aaaaaccata taagtgtggt
     1021 gaatgtggaa agtctttttg tcaaagctct aacctaagtg aacactgcag agttcatagt
     1081 ggagaaagac cttttgagtg tctggaatgt gggaaagcct ttgggtgcca ttctagtctt
     1141 ctgcggcacc agagaacaca cactggagaa tggccatatg aatgcagtga ctgtgggaga
     1201 ctgtttagac agattgtcag cctgattaca caccagagga ctcacactac cgagaagcct
     1261 tatgaatgtg gacagtgtga gaagtctttt agtcacaaag ccactcttac tgtacatcag
     1321 agagttcaca ctggggaaaa gccctatcac tgtgaagcct gtgggaaatc cttcagccaa
     1381 agtgccaacc ttattaaaca ctccaaaatt cacactggag aaaagcctta tgagtgtgga
     1441 gaatgcggtc tatgctttcg ccagagagct accctcatga aacaccagag aacccacacg
     1501 tcagaaaggc cttatgaatg tagagaatgt ggtaagttct ttaaacaata cttctacctc
     1561 attgaacacc gtaggattca caccacaaca gaattttatg agtgtgaaca gtgcgggaag
     1621 tcttataccc aaaaagccac ccttatcaga caccaacgag tccacacagg agagagtcct
     1681 tataaatgtg aggagtgtgg aaaagccttt gaatacaaat ccagacttaa gcgacatcaa
     1741 agaacgcaca ctggtgaaag gccttatgag tgtgccaaat gtgggaaatt cttcagagaa
     1801 agctacaatc ttgctgaaca ccagaaaatt cacactaaag caaagcctta ccattgtgat
     1861 cagtgtggga agtgttttag ccggagagct gacttggtta aacaccagag agttcacact
     1921 ggtgaaagac cttatacttg tggtgaatgt gggaagacct tcagccgaac taccaacctt
     1981 gttcaacaca gaagaattca cactggggaa cggccatacg agtgtgacca gtgtgggaaa
     2041 tcttttagcc aggtgtctac cctcactcga catcagctac ttcacactgg agaaaaaccg
     2101 tataagtgta gcaaatgaag gaaagtctag acagccctct agcatcttct aacaccaaaa
     2161 gatagaccat cacagctccc ggaagccaac ccttgaaagc accctcaggc ctccaaggat
     2221 attacattgt tcactgtaac aaactagaga gcctcataga gttctaggtc atgtaatttg
     2281 taccagagct agcctgcatg ttctggacag tctgtacccc ttgccagagt taaagagctg
     2341 tcataatgtc tcatagacac tgtctcttct ctagcacctt gcactgagtg catatgcacc
     2401 accaccaccc caccccaccc ttgcaacatg ccgtactctc cccttcccta atagaagcct
     2461 caacttcctg tgccttgcaa atgaccttga tccctttttc tcactggata tttctgggtc
     2521 tgtattttgc ctaaaggaac atggtctggg atgagtggga ggctccagca aggattatct
     2581 tctcaagtct gtctcacatg attcgtgtga ctgtttacat actccaaatc actagccagg
     2641 aacttcctgt caggatgtgc aataataaaa gaccttattt ttttttcccc catgtacttt
     2701 taatcaagag tttctattca cagacttagg cagccaaaat actatgatag gtcctgtttt
     2761 tgttttgttt aattattttt atttacattc aagccgttgc cttccatcac ctctccctca
     2821 agtcttcatc cccctccttt ttctccttgc cttcaagagg gtgcccctgc caccaggcct
     2881 cccccttccc tggtgcctca agtctctcaa ggcgtatctt ctcccactga ggccagacca
     2941 cgcagtcctc tgatatatat gtgctagggg ttgcctgttt ggtaggctct gtttatatag
     3001 aaattgtaac agtgtttggg ttttttattt aatatttatt tattgaatgt acatgtgtgc
     3061 tctgtcttca tgcacaccag aagagggaat caattctgag ccatcatgtg gttgctggaa
     3121 ttgaactcag gccctccaga agatcagcca gtgctcttaa catctgagcc atctctcctt
     3181 ccctggaaca ggtcttgagg ctgcaccatt catgcctcag catgggtaat gggaaagagt
     3241 agctctcgtt tatgttgctt tccaaaacct ttagtggaac aaagcagggt gttcagtcct
     3301 agctttgtgc tttttttgtt tgttgttggg aggaaggtgt tttgttttta gactaccctg
     3361 aggtcacttg ttggaactgc aacattcagt gctcttagaa tagctttaac ttatcccatc
     3421 attcccacat ggtctgacct gattatgccc aagattgtcg aagagaaact tttctatgag
     3481 gttcatagac accaagtcca taattccaaa tgtcacttga aaaattagga gaaccaaata
     3541 ggaacaataa cgggtagatt aatacaagct ttaagggtcg gagaggtggc tcagcagtta
     3601 agagcacccg actactcttc cagaggtcct gagttcaatt cccagcaacc acatggtggc
     3661 tcacaaccat ctgtaaagag atccgatgtc ctcttctgtt gtatctgaag acagctcagt
     3721 gtacttattt ataataaatg aataaatctt ttttaaaaaa tacaggtttt gataattgaa
     3781 aggtggggtt ttatatgaga acattacctg gggattgatt actctagaga ccacagatat
     3841 tgcattctgg aaaataattt gcctgtatct tgtgtcctga aatcttaact gagtctgaat
     3901 tcatgctgta acttatagcc agatttacag tgagcaacat cagcaaaacg ccaatcagaa
     3961 agattcaaaa gcaggcagtt ttgccaggaa cagaatgtat tgggagatac aaagaagcca
     4021 tagttactaa tgggatcaca ctgttaaaag aaactaagta ctttgtacta ggggtgtaga
     4081 aaaataataa agataccttg atggctcagc ttctcttcca gagatcctga gttccattcc
     4141 caggaactgc atggtggctc acaagcattt attaaggaat ctgatgccct cttctggtat
     4201 gtaggtgtat gtgcagatag cactcactta taaataaata aataaataaa taaataaata
     4261 atttttaatt tgttttaaaa a
//
LOCUS       NM_001438316            3187 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 3, mRNA.
ACCESSION   NM_001438316 XM_063284692
VERSION     NM_001438316.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063284692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.392950.1,
                                           SRR26360172.2087927.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  144815329-144815554 c
            227-401             JAXUCZ010000001.1  144794240-144794414 c
            402-590             JAXUCZ010000001.1  144734138-144734326 c
            591-814             JAXUCZ010000001.1  144723344-144723567 c
            815-1067            JAXUCZ010000001.1  144721538-144721790 c
            1068-1181           JAXUCZ010000001.1  144719060-144719173 c
            1182-1271           JAXUCZ010000001.1  144718672-144718761 c
            1272-1408           JAXUCZ010000001.1  144717593-144717729 c
            1409-1607           JAXUCZ010000001.1  144714015-144714213 c
            1608-1702           JAXUCZ010000001.1  144712661-144712755 c
            1703-1783           JAXUCZ010000001.1  144711957-144712037 c
            1784-3187           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3187
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..226
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1882
                     /gene="Cpeb1"
                     /note="isoform 3 is encoded by transcript variant 3; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 3"
                     /protein_id="NP_001425245.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MWPRGCLSAFLSRQGQEEESGRIKDCWDNQEVPALSTCSNANIF
                     RRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEEAITSRMLFPTSAQESPRGLPD
                     ANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSNTQSVLSMLQNPLGNVLGKTPLSFLSL
                     DPLGSDLDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRIS
                     PPLPFLSMTGNGPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGTSVWPSWDLL
                     GAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITE
                     AGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGYVYLVFELEKSVRALLQACSHDPLSPD
                     GLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEA
                     LAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKK
                     VQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQK
                     N"
     misc_feature    227..1129
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    227..1129
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1133..1441
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1133..1441
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1472..1723
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1472..1723
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1703..1870
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    1703..1870
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            227..401
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..590
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..814
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1067
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1181
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1271
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1408
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1607
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1702
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1783
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..3187
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgaggtc gcacgtgcgt gtgacggggc ttcgagggct gtccccggga gcctcgcggg
       61 tctgggggcg cgggcctgga ggtggagtca agcagcccgc gagggggcgc aggcgtggag
      121 cctgctagtc ctcggcggcg tccgctctcc tcggtcggcg gcctggcgag acgcactcat
      181 gtggcctcga ggctgtctct cagcttttct cagccggcaa ggccaggaag aagaatcagg
      241 aaggataaag gactgctggg acaaccaaga ggttcctgca ctctctacat gtagcaatgc
      301 caatatcttt cgaaggataa atgccatttt ggatgattca ctggacttca gtaaagtctg
      361 cacaacacct ataaatcgag gaattcatga tcagttgcca gacttccagg actctgaaga
      421 agcaattaca agcaggatgc ttttccccac ctctgcgcaa gaatctcccc gcggcctccc
      481 agatgcaaac ggtttgtgcc ttggcctgca gtcactcagt ctgactggct gggaccgacc
      541 ctggagcacc caggactcag actcctcagc ccagagcaac acacagtcag tattaagcat
      601 gctccaaaat ccactgggaa atgtcttagg aaaaaccccc ttgagcttcc tgtctctgga
      661 tccccttggg tctgacttgg acaagttccc agcgccctca gttagaggat ctcgcctgga
      721 cacccggcct atcctggact cccgttctag cagcccctct gactcagaca cgagtggctt
      781 cagctctgga tcagatcatc tctcagattt gatttcaagc cttcgcattt cccctcctct
      841 gccctttctt tctatgacgg gaaatggtcc cagagaccct ctaaagatgg gagttgggtc
      901 tcgaatggac caagagcaag ctgctcttgc tgcagttgct ccctctccaa ccagtgctcc
      961 aaagagatgg ccaggaactt ctgtgtggcc atcttgggac cttctcggag ctcctaaaga
     1021 cccattcagc atagagagag aggctagact ccacaggcag gccgcagctg tgaatgaagc
     1081 tacatgtacc tggagtggcc agcttcctcc ccggaactac aagaacccca tctactcatg
     1141 caaggtgttc ctaggaggtg ttccttggga cattacagaa gctggattgg ttaacacctt
     1201 ccgtgttttt ggctctctga gtgtggagtg gcctggtaag gatggcaagc acccccggtg
     1261 tcctcccaaa gggtatgtgt atttggtgtt tgaactagag aagtccgtcc gggccttgct
     1321 tcaggcttgt tctcatgacc cactgagccc agatggccta agtgaatatt atttcaagat
     1381 gtccagccga aggatgcgct gcaaagaagt acaggtaatc ccttgggtct tggctgacag
     1441 caactttgtc tggagcccat ctcagaggct ggatcccagc aggacggtgt ttgttggtgc
     1501 cttgcacggg atgctcaatg ctgaggctct ggctgccatc ttgaatgacc tatttggtgg
     1561 agtggtgtat gctgggattg acacagataa gcacaagtac cccattgggt ctggtcgtgt
     1621 gactttcaat aaccaacgta gttacctgaa agcagtcact gctgcttttg tggagatcaa
     1681 aaccaccaag tttaccaaga aggttcagat cgacccctat ctagaagatt ctctgtgtct
     1741 tatctgcagt tcacaacctg gtcctttctt ctgccgagat caggtctgct tcaagtactt
     1801 ttgccgaagc tgctggcact ggcgacacag catggaaggc ctacgccacc acagcccgct
     1861 aatgaggaac cagaagaact aaaattccag ctagagaagc tggcctggcc cagggcctgt
     1921 ggcgccaaag gctggcaagt caggcagcag cctgttccct gcacgggcgc ctaggagcta
     1981 gctttctgca gacaagggag aattgtactc acctttgtac ttgctgagtc tgtctttgtt
     2041 tctgcactaa ttaatgcaca atgagttttg tcaggttttg tcttcagcgg ggtgtgccag
     2101 agcaggggcc tcaggctcac cctcaagcaa ttgtagtttt cccagattct agttcctcat
     2161 tttgcaaatg aaaacaacaa aaaaaactgt gtctagaacg cgttgacaca gatgcctaca
     2221 cttgggttta tttattaaag cgcttcttac attccttgca atactgatgg tggtgatgcg
     2281 caggtctcat tggtccattc ttgcagttgc catacagtgc ctttccattt atttaacccc
     2341 cacctgaacg gcataaattg agtgttcagc tggtgttttt tactgtaaca aacaaaggag
     2401 actttgctct tcatttaaac caaatcatat ttcatagttt acgctcgagg gtttttactg
     2461 gttccttttt acactcctta aaacagtttt taagtcgttt ggaacaatag attttttttt
     2521 cttttttggc agcttttaac attatagcaa atttgtgtct gggggactgc tggtcacagt
     2581 tgcaaatcaa agcatttgta accaagagaa aaattatttt atttaaaact ggatgggagg
     2641 aaaaattagg tctgagcagc tgctgtatat agttttaaat ggtttgtcgc accttatgtt
     2701 gcacttacgt tgggggaggg ttgatagaag tttttaatca cagtcacagg actttttctt
     2761 ttgtaactga gcttaaaaat taaaaaaaaa aaaagggctg ctttttggtg ggggcggatg
     2821 aaggctcaca ggagcccttt ctcttagagg ggcaagtacc cttccttaca acttttattt
     2881 gaagaatgta tgaatcaaca gttattgttg acaaaaatgt tactggaatt gaaaacttga
     2941 ctcttttttt aaaaatttag ttactacttg cccctcttag ggaagctgtg tgccaaagaa
     3001 ccagtgtcgc ccccctgctg agctgacgtt gcattgtcgc atatcccagc tactctgtgg
     3061 gctcgtgaag ctgtgtgtga agtctctacc tcattgttgt acatgcaggc aagactgcac
     3121 tctgtacaga ttgtggagta agctgtggtg tacttttttt ggcacataat aaacacgttg
     3181 cagcaga
//
LOCUS       NM_001438321            2710 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 9, mRNA.
ACCESSION   NM_001438321 XM_063284737
VERSION     NM_001438321.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 2710)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 2710)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 2710)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 2710)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 2710)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 2710)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063284737.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.22560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  144815329-144815554 c
            227-401             JAXUCZ010000001.1  144794240-144794414 c
            402-590             JAXUCZ010000001.1  144734138-144734326 c
            591-704             JAXUCZ010000001.1  144719060-144719173 c
            705-794             JAXUCZ010000001.1  144718672-144718761 c
            795-931             JAXUCZ010000001.1  144717593-144717729 c
            932-1130            JAXUCZ010000001.1  144714015-144714213 c
            1131-1225           JAXUCZ010000001.1  144712661-144712755 c
            1226-1306           JAXUCZ010000001.1  144711957-144712037 c
            1307-2710           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2710
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..226
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1405
                     /gene="Cpeb1"
                     /note="isoform 9 is encoded by transcript variant 9; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 9"
                     /protein_id="NP_001425250.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MWPRGCLSAFLSRQGQEEESGRIKDCWDNQEVPALSTCSNANIF
                     RRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEEAITSRMLFPTSAQESPRGLPD
                     ANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSNTQSAVNEATCTWSGQLPPRNYKNPIY
                     SCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGYVYLVFELEKSV
                     RALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSR
                     TVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAV
                     TAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHS
                     MEGLRHHSPLMRNQKN"
     misc_feature    227..>724
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    227..>724
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    656..964
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    656..964
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    995..1246
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    995..1246
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1226..1393
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    1226..1393
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            227..401
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..590
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..704
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..794
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..931
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1130
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1225
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1306
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..2710
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtgaggtc gcacgtgcgt gtgacggggc ttcgagggct gtccccggga gcctcgcggg
       61 tctgggggcg cgggcctgga ggtggagtca agcagcccgc gagggggcgc aggcgtggag
      121 cctgctagtc ctcggcggcg tccgctctcc tcggtcggcg gcctggcgag acgcactcat
      181 gtggcctcga ggctgtctct cagcttttct cagccggcaa ggccaggaag aagaatcagg
      241 aaggataaag gactgctggg acaaccaaga ggttcctgca ctctctacat gtagcaatgc
      301 caatatcttt cgaaggataa atgccatttt ggatgattca ctggacttca gtaaagtctg
      361 cacaacacct ataaatcgag gaattcatga tcagttgcca gacttccagg actctgaaga
      421 agcaattaca agcaggatgc ttttccccac ctctgcgcaa gaatctcccc gcggcctccc
      481 agatgcaaac ggtttgtgcc ttggcctgca gtcactcagt ctgactggct gggaccgacc
      541 ctggagcacc caggactcag actcctcagc ccagagcaac acacagtcag ctgtgaatga
      601 agctacatgt acctggagtg gccagcttcc tccccggaac tacaagaacc ccatctactc
      661 atgcaaggtg ttcctaggag gtgttccttg ggacattaca gaagctggat tggttaacac
      721 cttccgtgtt tttggctctc tgagtgtgga gtggcctggt aaggatggca agcacccccg
      781 gtgtcctccc aaagggtatg tgtatttggt gtttgaacta gagaagtccg tccgggcctt
      841 gcttcaggct tgttctcatg acccactgag cccagatggc ctaagtgaat attatttcaa
      901 gatgtccagc cgaaggatgc gctgcaaaga agtacaggta atcccttggg tcttggctga
      961 cagcaacttt gtctggagcc catctcagag gctggatccc agcaggacgg tgtttgttgg
     1021 tgccttgcac gggatgctca atgctgaggc tctggctgcc atcttgaatg acctatttgg
     1081 tggagtggtg tatgctggga ttgacacaga taagcacaag taccccattg ggtctggtcg
     1141 tgtgactttc aataaccaac gtagttacct gaaagcagtc actgctgctt ttgtggagat
     1201 caaaaccacc aagtttacca agaaggttca gatcgacccc tatctagaag attctctgtg
     1261 tcttatctgc agttcacaac ctggtccttt cttctgccga gatcaggtct gcttcaagta
     1321 cttttgccga agctgctggc actggcgaca cagcatggaa ggcctacgcc accacagccc
     1381 gctaatgagg aaccagaaga actaaaattc cagctagaga agctggcctg gcccagggcc
     1441 tgtggcgcca aaggctggca agtcaggcag cagcctgttc cctgcacggg cgcctaggag
     1501 ctagctttct gcagacaagg gagaattgta ctcacctttg tacttgctga gtctgtcttt
     1561 gtttctgcac taattaatgc acaatgagtt ttgtcaggtt ttgtcttcag cggggtgtgc
     1621 cagagcaggg gcctcaggct caccctcaag caattgtagt tttcccagat tctagttcct
     1681 cattttgcaa atgaaaacaa caaaaaaaac tgtgtctaga acgcgttgac acagatgcct
     1741 acacttgggt ttatttatta aagcgcttct tacattcctt gcaatactga tggtggtgat
     1801 gcgcaggtct cattggtcca ttcttgcagt tgccatacag tgcctttcca tttatttaac
     1861 ccccacctga acggcataaa ttgagtgttc agctggtgtt ttttactgta acaaacaaag
     1921 gagactttgc tcttcattta aaccaaatca tatttcatag tttacgctcg agggttttta
     1981 ctggttcctt tttacactcc ttaaaacagt ttttaagtcg tttggaacaa tagatttttt
     2041 tttctttttt ggcagctttt aacattatag caaatttgtg tctgggggac tgctggtcac
     2101 agttgcaaat caaagcattt gtaaccaaga gaaaaattat tttatttaaa actggatggg
     2161 aggaaaaatt aggtctgagc agctgctgta tatagtttta aatggtttgt cgcaccttat
     2221 gttgcactta cgttggggga gggttgatag aagtttttaa tcacagtcac aggacttttt
     2281 cttttgtaac tgagcttaaa aattaaaaaa aaaaaaaggg ctgctttttg gtgggggcgg
     2341 atgaaggctc acaggagccc tttctcttag aggggcaagt acccttcctt acaactttta
     2401 tttgaagaat gtatgaatca acagttattg ttgacaaaaa tgttactgga attgaaaact
     2461 tgactctttt tttaaaaatt tagttactac ttgcccctct tagggaagct gtgtgccaaa
     2521 gaaccagtgt cgcccccctg ctgagctgac gttgcattgt cgcatatccc agctactctg
     2581 tgggctcgtg aagctgtgtg tgaagtctct acctcattgt tgtacatgca ggcaagactg
     2641 cactctgtac agattgtgga gtaagctgtg gtgtactttt tttggcacat aataaacacg
     2701 ttgcagcaga
//
LOCUS       NM_001438339            2117 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 17 (Ccdc17),
            transcript variant 2, mRNA.
ACCESSION   NM_001438339 XM_039110591
VERSION     NM_001438339.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced XM_039110591.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.145050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000005.1  135289630-135289897
            269-340             JAXUCZ010000005.1  135290021-135290092
            341-479             JAXUCZ010000005.1  135290215-135290353
            480-642             JAXUCZ010000005.1  135290433-135290595
            643-726             JAXUCZ010000005.1  135290679-135290762
            727-845             JAXUCZ010000005.1  135290841-135290959
            846-959             JAXUCZ010000005.1  135291156-135291269
            960-1090            JAXUCZ010000005.1  135291471-135291601
            1091-1182           JAXUCZ010000005.1  135291710-135291801
            1183-1386           JAXUCZ010000005.1  135291946-135292149
            1387-1765           JAXUCZ010000005.1  135292273-135292651
            1766-2117           JAXUCZ010000005.1  135292988-135293339
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2117
                     /gene="Ccdc17"
                     /note="coiled-coil domain containing 17"
                     /db_xref="GeneID:500528"
                     /db_xref="RGD:1598211"
     exon            1..268
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Ccdc17"
                     /note="upstream in-frame stop codon"
     CDS             146..1900
                     /gene="Ccdc17"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 17"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 17 isoform
                     2"
                     /protein_id="NP_001425268.1"
                     /db_xref="GeneID:500528"
                     /db_xref="RGD:1598211"
                     /translation="MADYSGKSGLLPCESCDMVFRSRALLAKHTKRFCIGGLTPEIMA
                     QEQRRSDQEATKSSLKRLTEEKIGPWATDTSQTAGSPEERLRDLQGTRARRVEETEAQ
                     SRALKQRGEELKRRLHSVAGPKGGLPRPIVLERELRELREEASRTRGALQTLGARVQA
                     LQPQPAHQQDAKRVVEFCCLPLRYNPETLAEEIRVLREVYVRGGGRDPEVLDKILQLQ
                     VEASALELRRSQNRKEKASAASEEALMVEAENRILEAEILALQKQKVLSLSPWGSRDL
                     WRHLSRRSDNSLLPPPVAPPMPPVTSSTKVQDFHGTSKAIINGTMTRNLGLDLHFLPA
                     SNVLGPAPYDPGAGLVIFYDFLRGLEASWIWVQLMTSLARDGQDTGGATALPPALCLP
                     PPSASGPIGNCAILASRQPVPRLPPSPLLSLICKLQAWQGVTWTPQPKAWASLLLFDQ
                     SLRVLSGRWRLPLRVPPTTSLSFAQMNEMPQVSVEGRDWLHPKIPMEYHFLCQAGQAE
                     LFLRLVNARDTDAQTLAEINPASAHEYQYPPMMSSSSSLESSFFTHSSGIADPPPPTE
                     ETFVSVEDKDEHLSPHQF"
     exon            269..340
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            341..479
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            480..642
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            643..726
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            727..845
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            846..959
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1090
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1182
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1386
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1765
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2117
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacataaac ataaatttga aggacttgga gatgtagcag agttggtcta ttctttgtct
       61 ctttgctctc ttttctttcc agtctacctt ttccctttta ccacatcctc tgtaggacgc
      121 tggtgtcttt aacagattcc atcccatggc cgattactct gggaagtcag gacttttgcc
      181 ctgtgagtcc tgtgatatgg ttttccgctc cagagctttg ttggccaaac acaccaagcg
      241 attctgcatt ggcggactga ctccggagat tatggcacaa gaacagaggc gttcagatca
      301 ggaggccacc aaatcttctc taaagagact gacagaggag aaaataggtc cctgggcgac
      361 tgacacttcc cagactgcag ggagccctga ggagaggctg cgagacttgc agggaacacg
      421 agccagacgc gtggaggaaa ctgaagcgca aagccgagcg ctgaagcaac gcggcgaaga
      481 attaaaacgg cgcctccaca gcgtagcggg acccaaggga ggattacccc gcccaatagt
      541 cttggagcgc gaactcagag aactcaggga agaggccagc cggacacggg gagcgctgca
      601 aacgttagga gcgcgtgttc aggcgctcca gcctcagccc gcccaccagc aggacgccaa
      661 aagggtagtg gaattctgtt gcctgcccct acggtacaac ccggaaacgc ttgctgaaga
      721 gatccgggtg ctacgtgagg tctacgtgcg cggtggaggc cgggacccag aagttctgga
      781 caaaatatta caactgcaag tggaggcgtc agcactggaa ttgcggcggt cgcaaaaccg
      841 caaggaaaaa gcaagtgccg cctctgagga ggctctaatg gtggaagccg aaaacaggat
      901 cctggaggca gaaattctgg ccttgcagaa gcagaaagtc ctgagtctgt cgccctgggg
      961 ttccagggat ctctggcgac acttgagtag aaggagtgat aactccctcc tccctccacc
     1021 agttgcaccc ccaatgccac cagttacaag ttccacaaaa gtccaggact tccacggcac
     1081 ttcaaaggct ataattaatg gaaccatgac aagaaacttg ggtctggatc tccacttcct
     1141 accagcatcg aatgttctag gtcctgcacc ctatgatcct ggggctggcc ttgtcatttt
     1201 ctatgacttc ctgcggggcc ttgaggcttc ttggatttgg gtgcagctaa tgacaagctt
     1261 ggcccgagat ggacaggata caggaggggc cacagcacta cctccagcac tttgcttgcc
     1321 gccaccttca gcttctggac ctataggcaa ctgtgctatc ctcgcaagca ggcaacctgt
     1381 gccgaggctg cctccatcac cactgctatc tttgatctgc aaactacagg cctggcaggg
     1441 tgttacatgg acaccacaac caaaggcttg ggcctcacta ctgctatttg accaaagtct
     1501 gagggtgctt agtggccgtt ggcgcctccc acttcgggtc cctcctacca ccagcctcag
     1561 ctttgcccag atgaatgaga tgccccaggt aagtgtagag ggtagagact ggttgcaccc
     1621 caagattcca atggagtacc acttcctctg tcaggccggc caagctgagc tctttctgag
     1681 gctggtaaac gcaagagata cagatgccca gacattggca gagatcaatc cagcaagtgc
     1741 ccatgagtac cagtacccac caatgatgtc cagttcatct tccctggaat ccagtttctt
     1801 cacccacagt tctggcattg ctgaccctcc acctcccaca gaagagactt ttgtcagtgt
     1861 cgaggataaa gatgagcact tgagtcctca ccagttttga aggaaacact aatttctaga
     1921 cctgcagctt ttaaaatggg gtcttacagc agcagcaaac atttgatcct taaatactgg
     1981 gtggctacaa agaacactaa acctgctttt cttaaactag ccaactttat ataaaaagcc
     2041 aactaatttt cttctgcatt tactttcctt ttataaagca gatccaggaa taaatgacct
     2101 caaaatattt agtcaaa
//
LOCUS       NM_053741               1458 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a),
            transcript variant 2, mRNA.
ACCESSION   NM_053741
VERSION     NM_053741.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Hu,Y., Hong,X.Y., Yang,X.F., Ma,R.H., Wang,X., Zhang,J.F., Feng,Q.,
            Li,X.G., Sun,D.S., Li,X., Wan,H.L., Li,T., Wang,Q., Ke,D.,
            Wang,J.Z. and Liu,G.P.
  TITLE     Inflammation-dependent ISG15 upregulation mediates MIA-induced
            dendrite damages and depression by disrupting NEDD4/Rap2A signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1477-1489 (2019)
   PUBMED   30826466
  REMARK    GeneRIF: The data revealed that maternal immune activation impedes
            offspring's dendrite development and causes depressive like
            behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A
            signaling.
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Emery,A.C., Xu,W., Eiden,M.V. and Eiden,L.E.
  TITLE     Guanine nucleotide exchange factor Epac2-dependent activation of
            the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest
            in neuroendocrine cells
  JOURNAL   J Biol Chem 292 (29), 12220-12231 (2017)
   PUBMED   28546426
  REMARK    GeneRIF: Data suggest that Rap2A is the obligate effector for Epac2
            in mediating growth arrest and reversal of neurite extension
            through activation of MAP kinase signaling via protein
            phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS
            oncogene family member Rap2A; Epac2 = guanine nucleotide exchange
            factor Epac2)
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Kawabe,H., Neeb,A., Dimova,K., Young,S.M. Jr., Takeda,M.,
            Katsurabayashi,S., Mitkovski,M., Malakhova,O.A., Zhang,D.E.,
            Umikawa,M., Kariya,K., Goebbels,S., Nave,K.A., Rosenmund,C.,
            Jahn,O., Rhee,J. and Brose,N.
  TITLE     Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls
            neurite development
  JOURNAL   Neuron 65 (3), 358-372 (2010)
   PUBMED   20159449
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Taira,K., Umikawa,M., Takei,K., Myagmar,B.E., Shinzato,M.,
            Machida,N., Uezato,H., Nonaka,S. and Kariya,K.
  TITLE     The Traf2- and Nck-interacting kinase as a putative effector of
            Rap2 to regulate actin cytoskeleton
  JOURNAL   J Biol Chem 279 (47), 49488-49496 (2004)
   PUBMED   15342639
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Machida,N., Umikawa,M., Takei,K., Sakima,N., Myagmar,B.E.,
            Taira,K., Uezato,H., Ogawa,Y. and Kariya,K.
  TITLE     Mitogen-activated protein kinase kinase kinase kinase 4 as a
            putative effector of Rap2 to activate the c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 279 (16), 15711-15714 (2004)
   PUBMED   14966141
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Menetrey,J. and Cherfils,J.
  TITLE     Structure of the small G protein Rap2 in a non-catalytic complex
            with GTP
  JOURNAL   Proteins 37 (3), 465-473 (1999)
   PUBMED   10591105
REFERENCE   9  (bases 1 to 1458)
  AUTHORS   Cherfils,J., Menetrey,J., Le Bras,G., Janoueix-Lerosey,I., de
            Gunzburg,J., Garel,J.R. and Auzat,I.
  TITLE     Crystal structures of the small G protein Rap2A in complex with its
            substrate GTP, with GDP and with GTPgammaS
  JOURNAL   EMBO J 16 (18), 5582-5591 (1997)
   PUBMED   9312017
REFERENCE   10 (bases 1 to 1458)
  AUTHORS   Lerosey,I., Chardin,P., de Gunzburg,J. and Tavitian,A.
  TITLE     The product of the rap2 gene, member of the ras superfamily.
            Biochemical characterization and site-directed mutagenesis
  JOURNAL   J Biol Chem 266 (7), 4315-4321 (1991)
   PUBMED   1900290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 14, 2025 this sequence version replaced NM_053741.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887622.3512172.1, AY037826.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1458              JAXUCZ010000015.1  104003477-104004934
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..1458
                     /gene="Rap2a"
                     /note="RAP2A, member of RAS oncogene family"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
     exon            1..1458
                     /gene="Rap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..590
                     /gene="Rap2a"
                     /EC_number="3.6.5.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rap2A-like protein; ras-related protein Rap-2a; RAS
                     related protein 2a inverted question mark"
                     /codon_start=1
                     /product="ras-related protein Rap-2a isoform 2"
                     /protein_id="NP_446193.1"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKR"
     misc_feature    318..>587
                     /gene="Rap2a"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    318..>587
                     /gene="Rap2a"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    375..377
                     /gene="Rap2a"
                     /note="G2 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    375..377
                     /gene="Rap2a"
                     /note="G2 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    384..392
                     /gene="Rap2a"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    384..392
                     /gene="Rap2a"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    441..452
                     /gene="Rap2a"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    441..452
                     /gene="Rap2a"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(447..452,498..503)
                     /gene="Rap2a"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(447..452,498..503)
                     /gene="Rap2a"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
ORIGIN      
        1 ggcattgcgg ggccgcggtt cgggcggctc cggctcgggc tcgagctccg ttgctgccgg
       61 cgccctccag gctgcatcgt cctccggctt ggcccgctca cagggccgcg cgctgctccc
      121 tcagttgtag ctccgctgcc ggcgcccagg gcgctgccgc ggccgtgagc cggcgtgtcc
      181 gtaagggcgg cggggccgcg gggtcggggc gcggcgcgcg ggcgcaggtc tatgtcgcgg
      241 gcggcggcgg cggcggcggc cgcgcaggga cgatgcgcga gtacaaagtg gtggtgctgg
      301 gctcgggcgg ggtaggcaaa tccgccctga ccgtgcagtt cgtgaccggc accttcattg
      361 agaaatacga ccccaccatc gaggacttct accgcaagga gatcgaggtg gactcgtcgc
      421 cttcggtgtt ggagatcctg gacacggcgg gcaccgagca gttcgcgtcc atgcgggacc
      481 tgtacatcaa gaacggccag ggcttcatcc tggtctacag cctggtcaac cagcagagct
      541 tccaggatat caagcccatg cgggaccaga tcatccgcgt gaagcggtga gcagagcggg
      601 gcgcacgggg gctcggtggc tgcggcgatc ccggtccctg gctcgcccgg gctacaccac
      661 ctccttccgg ggctcagact tgcgggcttt gtttcacaag taaaattggg cagcccgtta
      721 acccccagct cagccctttg tttctaggac attggtagcg ctccttctgg accccagaga
      781 aaacaaagtt tcaaacttgc aagaagagaa gggatgagta ggtgggcgct agggaaaggg
      841 gagctgtcta agtggaggca cgtctgtgca gagtgagcgc gcgcttaaat ccacccttca
      901 gaggtttgac agccagaatt cgcacgtaca tatcttgtga cagtgtcaat actagttaag
      961 gggccctttc ttgtcgcgga aaagattaaa tgttgtcagg aggttggcag aaatgaatta
     1021 gtgcaaaact ttaaaggcac attggcaaat aattcgaaga ccacataaca ttcacgaggt
     1081 ttggcatata gaaacacgct tgtgacattt acgttgaaag agtgcatttc tcttcctctc
     1141 ttaaaagcta gccttcccac cccgccccct caaaaaaaaa aaaaaaaaaa aaaaaaaagg
     1201 aaggaggcta ttcttggaaa ccaaacagaa gtttagtatg agctgtggct tgtgtatcag
     1261 ctaatttaaa gttagtgcgg gggggggggg gggacaaaca cgctttttct tgatgtaaac
     1321 tgttcaaaga atgcattttg catgtggcag taacctgaat gctttcagtg tttgttttct
     1381 cttaagttga tgccatgtat ttttaccctc aaccttttaa atatcaaagt ctaacatgtt
     1441 attacagagt tttggcaa
//
LOCUS       NM_001191962            3023 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus G-protein signaling modulator 2 (Gpsm2), mRNA.
ACCESSION   NM_001191962 XM_008761409 XM_575015
VERSION     NM_001191962.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3023)
  AUTHORS   Chiu,C.W.N., Monat,C., Robitaille,M., Lacomme,M., Daulat,A.M.,
            Macleod,G., McNeill,H., Cayouette,M. and Angers,S.
  TITLE     SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by
            Negatively Regulating the Galphai-LGN-NuMA Ternary Complex
  JOURNAL   Dev Cell 36 (1), 50-62 (2016)
   PUBMED   26766442
REFERENCE   2  (bases 1 to 3023)
  AUTHORS   Bird,S.L., Heald,R. and Weis,K.
  TITLE     RanGTP and CLASP1 cooperate to position the mitotic spindle
  JOURNAL   Mol Biol Cell 24 (16), 2506-2514 (2013)
   PUBMED   23783028
REFERENCE   3  (bases 1 to 3023)
  AUTHORS   Kiyomitsu,T. and Cheeseman,I.M.
  TITLE     Cortical dynein and asymmetric membrane elongation coordinately
            position the spindle in anaphase
  JOURNAL   Cell 154 (2), 391-402 (2013)
   PUBMED   23870127
  REMARK    Erratum:[Cell. 2013 Sep 12;154(6):1401]
REFERENCE   4  (bases 1 to 3023)
  AUTHORS   Jia,M., Li,J., Zhu,J., Wen,W., Zhang,M. and Wang,W.
  TITLE     Crystal structures of the scaffolding protein LGN reveal the
            general mechanism by which GoLoco binding motifs inhibit the
            release of GDP from Galphai
  JOURNAL   J Biol Chem 287 (44), 36766-36776 (2012)
   PUBMED   22952234
REFERENCE   5  (bases 1 to 3023)
  AUTHORS   Kotak,S., Busso,C. and Gonczy,P.
  TITLE     Cortical dynein is critical for proper spindle positioning in human
            cells
  JOURNAL   J Cell Biol 199 (1), 97-110 (2012)
   PUBMED   23027904
REFERENCE   6  (bases 1 to 3023)
  AUTHORS   Walsh,T., Shahin,H., Elkan-Miller,T., Lee,M.K., Thornton,A.M.,
            Roeb,W., Abu Rayyan,A., Loulus,S., Avraham,K.B., King,M.C. and
            Kanaan,M.
  TITLE     Whole exome sequencing and homozygosity mapping identify mutation
            in the cell polarity protein GPSM2 as the cause of nonsyndromic
            hearing loss DFNB82
  JOURNAL   Am J Hum Genet 87 (1), 90-94 (2010)
   PUBMED   20602914
REFERENCE   7  (bases 1 to 3023)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Two forms of human Inscuteable-related protein that links Par3 to
            the Pins homologues LGN and AGS3
  JOURNAL   Biochem Biophys Res Commun 341 (4), 1001-1006 (2006)
   PUBMED   16458856
REFERENCE   8  (bases 1 to 3023)
  AUTHORS   Sans,N., Wang,P.Y., Du,Q., Petralia,R.S., Wang,Y.X., Nakka,S.,
            Blumer,J.B., Macara,I.G. and Wenthold,R.J.
  TITLE     mPins modulates PSD-95 and SAP102 trafficking and influences NMDA
            receptor surface expression
  JOURNAL   Nat Cell Biol 7 (12), 1179-1190 (2005)
   PUBMED   16299499
  REMARK    Erratum:[Nat Cell Biol. 2006 Jan;8(1):100]
REFERENCE   9  (bases 1 to 3023)
  AUTHORS   Du,Q. and Macara,I.G.
  TITLE     Mammalian Pins is a conformational switch that links NuMA to
            heterotrimeric G proteins
  JOURNAL   Cell 119 (4), 503-516 (2004)
   PUBMED   15537540
REFERENCE   10 (bases 1 to 3023)
  AUTHORS   Du,Q., Stukenberg,P.T. and Macara,I.G.
  TITLE     A mammalian Partner of inscuteable binds NuMA and regulates mitotic
            spindle organization
  JOURNAL   Nat Cell Biol 3 (12), 1069-1075 (2001)
   PUBMED   11781568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_008761409.3, NM_001191962.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.11018.1,
                                           SRR26643286.8603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000002.1  199062890-199063148 c
            260-563             JAXUCZ010000002.1  199054750-199055053 c
            564-785             JAXUCZ010000002.1  199048483-199048704 c
            786-921             JAXUCZ010000002.1  199047928-199048063 c
            922-1064            JAXUCZ010000002.1  199045721-199045863 c
            1065-1188           JAXUCZ010000002.1  199044981-199045104 c
            1189-1304           JAXUCZ010000002.1  199044764-199044879 c
            1305-1460           JAXUCZ010000002.1  199041298-199041453 c
            1461-1569           JAXUCZ010000002.1  199039550-199039658 c
            1570-1699           JAXUCZ010000002.1  199038984-199039113 c
            1700-1770           JAXUCZ010000002.1  199030888-199030958 c
            1771-1950           JAXUCZ010000002.1  199027992-199028171 c
            1951-2101           JAXUCZ010000002.1  199018243-199018393 c
            2102-2319           JAXUCZ010000002.1  199017248-199017465 c
            2320-3023           JAXUCZ010000002.1  199015250-199015953 c
FEATURES             Location/Qualifiers
     source          1..3023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3023
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="G-protein signaling modulator 2"
                     /db_xref="GeneID:362021"
                     /db_xref="RGD:1560967"
     exon            1..259
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            260..563
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    496..498
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="upstream in-frame stop codon"
     CDS             508..2544
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="G-protein signalling modulator 2 (AGS3-like, C.
                     elegans); G-protein signaling modulator 2 (AGS3-like, C.
                     elegans)"
                     /codon_start=1
                     /product="G-protein-signaling modulator 2"
                     /protein_id="NP_001178891.1"
                     /db_xref="GeneID:362021"
                     /db_xref="RGD:1560967"
                     /translation="MEGNLMSMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGV
                     SFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEA
                     KASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG
                     CPGPQDVGEFPEEVRLALQAAVELYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF
                     RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYRKTLLLARQLK
                     DRAVEAQSCYSLGNTYTLLQDYEKAIEYHLKHLAIAQELKDRIGEGRACWSLGNAYTA
                     LGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEI
                     DGSLHGAGTKLGRRHSMENMELMKLTPEKVPNWNSEILAKQKPCIAKSSAKLLFVNRL
                     KGKKSKSGSASTKALHHASNPIDHRAPHAQKKVGSDAVGDEGFFDLLRRLQSSRMEDQ
                     RCHLQENRTASVAASSATPKMVKAPSASVVSPNTDEFLDLLASSQSRRLDDQRASFSN
                     LPGLRLTEGNNQSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPPAATKGPT
                     VPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK"
     misc_feature    586..663
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    586..663
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    697..777
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    697..777
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    700..1512
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; Region: TPR; COG0457"
                     /db_xref="CDD:440225"
     misc_feature    700..1512
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; Region: TPR; COG0457"
                     /db_xref="CDD:440225"
     misc_feature    order(703..708,715..720,724..726,814..816,823..828,
                     835..840,844..849,934..936,943..948,955..960,967..969)
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(703..708,715..720,724..726,814..816,823..828,
                     835..840,844..849,934..936,943..948,955..960,967..969)
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    808..900
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    808..900
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1114..1197
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1114..1197
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    order(1234..1236,1243..1248,1255..1260,1264..1266,
                     1354..1356,1363..1368,1375..1380,1384..1389,1474..1476,
                     1483..1488,1495..1500,1507..1509)
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    order(1234..1236,1243..1248,1255..1260,1264..1266,
                     1354..1356,1363..1368,1375..1380,1384..1389,1474..1476,
                     1483..1488,1495..1500,1507..1509)
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="putative protein binding surface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:276809"
     misc_feature    1234..1317
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1234..1317
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1348..1440
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1348..1440
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1471..1557
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1471..1557
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="TPR repeat [structural motif]; Region: TPR repeat"
                     /db_xref="CDD:276809"
     misc_feature    1477..1584
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="Tetratricopeptide repeat; Region: TPR_7; pfam13176"
                     /db_xref="CDD:433012"
     misc_feature    1477..1584
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="Tetratricopeptide repeat; Region: TPR_7; pfam13176"
                     /db_xref="CDD:433012"
     misc_feature    1975..2043
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="LGN motif, putative GEFs specific for G-alpha
                     GTPases; Region: GoLoco; smart00390"
                     /db_xref="CDD:214645"
     misc_feature    1975..2043
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="LGN motif, putative GEFs specific for G-alpha
                     GTPases; Region: GoLoco; smart00390"
                     /db_xref="CDD:214645"
     misc_feature    2134..2199
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="GoLoco motif; Region: GoLoco; pfam02188"
                     /db_xref="CDD:460481"
     misc_feature    2134..2199
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="GoLoco motif; Region: GoLoco; pfam02188"
                     /db_xref="CDD:460481"
     misc_feature    2284..2352
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="LGN motif, putative GEFs specific for G-alpha
                     GTPases; Region: GoLoco; smart00390"
                     /db_xref="CDD:214645"
     misc_feature    2284..2352
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="LGN motif, putative GEFs specific for G-alpha
                     GTPases; Region: GoLoco; smart00390"
                     /db_xref="CDD:214645"
     misc_feature    2389..2454
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="GoLoco motif; Region: GoLoco; pfam02188"
                     /db_xref="CDD:460481"
     misc_feature    2389..2454
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="GoLoco motif; Region: GoLoco; pfam02188"
                     /db_xref="CDD:460481"
     exon            564..785
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            786..921
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1064
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1188
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1304
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1460
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1569
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1699
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1770
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1950
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2101
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2319
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..3023
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggagc tcaggcgctg aggagaccta gctgacggtg agaccctccg agaggccagg
       61 gggagtccga agctctggcc cacgtgacct tccgggggcg ggcgccgggg gcgcgggcca
      121 gcctcccgcg gtgcccctgc ttggctcggc gtcgccccgg ggaccagcct tggggaagcg
      181 cggcgatccc cagtctgcgg tcggaggcgc tcatccctga agcggctccg cgttcccagg
      241 agcctcccgc cggagggaga aatgttgctg aagcgctgct gaaggggcca cagatgcaag
      301 gatttgggac acgtttgaac ctttaagctg tctgacattg acctcctttc attattaata
      361 aagaagaagc aggagcttag gatatattaa caccaactca ttaatgtact aaccggacag
      421 tgctctgcaa accccactgc gcagtaaagg actggactgg cccaggacac aatcatttcg
      481 catttcctca gcttataata tgactggatg gagggaaatt tgatgagcat gagggaagac
      541 cattcctttc atgtccgcta cagaatggaa gcttcttgcc tcgagctggc cttggaagga
      601 gaacgtctgt gtaaatcagg ggactgccgc gctggcgttt cgttttttga agccgcggtt
      661 caagttggaa ctgaagacct gaaaacgctc agtgctattt acagccagct gggcaacgct
      721 tacttctact tacacgacta cgccaaggcg ctagagtacc accaccatga cttaaccctg
      781 gcgaggacta ttggagacca gctcggggaa gcgaaagcca gcggcaatct tggaaacacc
      841 ttgaaggtgc ttgggaactt cgatgaagcg atagtgtgtt gccagcgaca cctggatatc
      901 tccagagaac ttaatgacaa ggtgggagaa gcaagagctc tctataatct tggaaatgtg
      961 tatcacgcca aagggaaaag tttcggctgc ccaggtccac aagatgtagg agagtttcca
     1021 gaagaagtga ggctcgccct acaggcagct gtggagctct atgaggaaaa cctgtcgtta
     1081 gtaactgctc taggtgaccg agcagcccag ggacgagcct ttgggaacct cggcaacaca
     1141 cactacctcc tcggcaactt cagggatgcc gttatagctc atgagcagcg tctcctgatt
     1201 gcaaaagagt tcggagataa ggcggccgaa agaagagcgt acagcaacct cggaaatgcg
     1261 tacatattcc ttggtgaatt cgaaactgct tccgaatact acaggaagac actgctgctg
     1321 gctcggcagc tgaaagacag agccgtggaa gctcagtcct gctacagtct tgggaataca
     1381 tacactctgc ttcaggacta cgagaaggcc atcgagtacc acctcaagca cttagcgatt
     1441 gcccaggagc tcaaggatcg aattggtgaa gggagagcgt gttggagttt aggaaatgca
     1501 tacacggctc taggaaatca tgaccaagca atgcattttg ctgaaaagca cttggaaatt
     1561 tcaagagagg ttggggacaa aagcggcgag ctgactgcac ggctgaacct ctcagacctg
     1621 cagatggttc ttggtctgag ctatagcaca aataattcca tgatgtctga gaacatcgaa
     1681 atcgatggca gcttacatgg tgcaggcacc aaactgggac gaagacatag tatggagaac
     1741 atggaactta tgaagttaac accagaaaag gtcccgaatt ggaacagtga aattctcgct
     1801 aaacagaaac cttgcattgc caaatcgtct gcaaagctcc tatttgtcaa cagactgaag
     1861 gggaaaaagt ccaaaagcgg cagcgcctcc actaaggctc tccaccacgc cagcaacccc
     1921 atcgaccacc gcgctccaca tgcccagaag aaagtcggct cggacgcggt cggagatgag
     1981 ggattctttg acttactgag gcgacttcag agcagcagga tggaggacca gaggtgccac
     2041 ttacaggaga accggacagc gtccgtggcc gcttcctctg ctacccccaa gatggtgaaa
     2101 gcaccgtcgg cttctgtggt atcccccaac accgatgagt ttttagatct ccttgctagc
     2161 tcgcagagcc gccgtctgga tgaccagagg gccagcttca gtaatttgcc agggctccgt
     2221 ctgacagaag gcaacaatca gtccgtactt gagcgcctga tgacaaatga caagaaagag
     2281 cctgatgagg acttctttga catccttgta aagtgtcagg ggtccaggtt agatgatcag
     2341 agatgtgctc caccacctgc tgccacaaag gggccgactg tccccgacga agactttttt
     2401 agcctcattt tacgctctca agctaaaagg atggatgaac aaagagttct gctacagaga
     2461 gatccaaaca gggacagtga gtttggacta aaggaacttt tgcaaaataa tgctctgttg
     2521 gaatttaagc attcagggaa ataactagca aaccacaaga tggtgtggta tttcctacta
     2581 aagaaaagga ggttccctcg ggacactgca gggaaactca tcttacacag caccgtagta
     2641 gtcaccaagt tttccgggtg taaatgttga agtactaagg gactgaaagg tgcttcttca
     2701 acctacccga ccttgagact ctgcttgggt gacttaagat tccttggcta gggtttgtgt
     2761 actaggaatt taaacgaatc ctacactaga attcagtcct ttcttactga ggtcattttt
     2821 taaggatcta gttaacaatg acttttttat atacccgccc aagaatatag tggattgcat
     2881 tgtttactga aaataatgta aatttcctat gtaaaaaagg tgaaaatagt cataaaattc
     2941 tagcttaaga aaactatatt caatatattt ttaggcaaag ccagtgaagg agatgagaaa
     3001 taaactactt ttagcatgcc ttg
//
LOCUS       NM_058208               2215 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus suppressor of cytokine signaling 2 (Socs2), mRNA.
ACCESSION   NM_058208 XM_017595137
VERSION     NM_058208.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Sheng,M., Huang,Z., Pan,L., Yu,M., Yi,C., Teng,L., He,L., Gu,C.,
            Xu,C. and Li,J.
  TITLE     SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion
            in diabetic mice and H9c2 cells through inhibiting the
            JAK-STAT-IGF-1 pathway
  JOURNAL   Life Sci 188, 101-109 (2017)
   PUBMED   28867579
  REMARK    GeneRIF: research suggests that overexpressed SOCS2 might
            exacerbate myocardial ischemia/reperfusion injury in type 2
            diabetes mellitus by inhibiting the expression of Insulin-like
            Growth Factor-1 via the Janus kinase-signal transducer and
            activator of transcription signaling pathway.
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Choi,J.S., Shin,Y.J., Lee,J.Y., Choi,J.Y., Cha,J.H., Chun,M.H. and
            Lee,M.Y.
  TITLE     Enhanced expression of SOCS-2 in the rat hippocampus after
            transient forebrain ischemia
  JOURNAL   J Neurotrauma 26 (11), 2097-2106 (2009)
   PUBMED   19469688
  REMARK    GeneRIF: SOCS-2 may be involved in glial reactions, and possibly
            adult hippocampal neurogenesis during ischemic insults.
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Isshiki,K., He,Z., Maeno,Y., Ma,R.C., Yasuda,Y., Kuroki,T.,
            White,G.S., Patti,M.E., Weir,G.C. and King,G.L.
  TITLE     Insulin regulates SOCS2 expression and the mitogenic effect of
            IGF-1 in mesangial cells
  JOURNAL   Kidney Int 74 (11), 1434-1443 (2008)
   PUBMED   19008912
  REMARK    GeneRIF: insulin can inhibit the mitogenic action of IGF-1 in
            mesangial cells by regulating STAT5/SOCS2 expression.
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Hamilton,K.L., Lin,L., Wang,Y. and Knowlton,A.A.
  TITLE     Effect of ovariectomy on cardiac gene expression: inflammation and
            changes in SOCS gene expression
  JOURNAL   Physiol Genomics 32 (2), 254-263 (2008)
   PUBMED   17986523
  REMARK    GeneRIF: Data show that althhough we observed OVX-related increases
            in SOCS2 and SOCS3 mRNA, SOCS2 and SOCS3 protein did not differ
            among groups.
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Haffner,M.C., Petridou,B., Peyrat,J.P., Revillion,F.,
            Muller-Holzner,E., Daxenbichler,G., Marth,C. and Doppler,W.
  TITLE     Favorable prognostic value of SOCS2 and IGF-I in breast cancer
  JOURNAL   BMC Cancer 7, 136 (2007)
   PUBMED   17651480
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Lindeman,G.J., Wittlin,S., Lada,H., Naylor,M.J., Santamaria,M.,
            Zhang,J.G., Starr,R., Hilton,D.J., Alexander,W.S., Ormandy,C.J. and
            Visvader,J.
  TITLE     SOCS1 deficiency results in accelerated mammary gland development
            and rescues lactation in prolactin receptor-deficient mice
  JOURNAL   Genes Dev 15 (13), 1631-1636 (2001)
   PUBMED   11445538
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Johnson,T.S., O'Leary,M., Justice,S.K., Maamra,M.,
            Zarkesh-Esfahani,S.H., Furlanetto,R., Preedy,V.R., Hinds,C.J., El
            Nahas,A.M. and Ross,R.J.
  TITLE     Differential expression of suppressors of cytokine signalling genes
            in response to nutrition and growth hormone in the septic rat
  JOURNAL   J Endocrinol 169 (2), 409-415 (2001)
   PUBMED   11312157
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Horvat,S. and Medrano,J.F.
  TITLE     Lack of Socs2 expression causes the high-growth phenotype in mice
  JOURNAL   Genomics 72 (2), 209-212 (2001)
   PUBMED   11401434
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Mao,Y., Ling,P.R., Fitzgibbons,T.P., McCowen,K.C., Frick,G.P.,
            Bistrian,B.R. and Smith,R.J.
  TITLE     Endotoxin-induced inhibition of growth hormone receptor signaling
            in rat liver in vivo
  JOURNAL   Endocrinology 140 (12), 5505-5515 (1999)
   PUBMED   10579313
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   Dey,B.R., Spence,S.L., Nissley,P. and Furlanetto,R.W.
  TITLE     Interaction of human suppressor of cytokine signaling (SOCS)-2 with
            the insulin-like growth factor-I receptor
  JOURNAL   J Biol Chem 273 (37), 24095-24101 (1998)
   PUBMED   9727029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 10, 2025 this sequence version replaced
            XM_017595137.3, NM_058208.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.20038.1,
                                           SRR26643293.39615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000007.1  31931839-31932025   c
            188-548             JAXUCZ010000007.1  31930063-31930423   c
            549-2215            JAXUCZ010000007.1  31926708-31928374   c
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2215
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="suppressor of cytokine signaling 2"
                     /db_xref="GeneID:84607"
                     /db_xref="RGD:69273"
     exon            1..187
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..548
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    332..334
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="upstream in-frame stop codon"
     CDS             410..1006
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="cytokine-inducible SH2 protein 2; cytokine
                     inducible SH2-containing protein 2"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 2"
                     /protein_id="NP_478115.1"
                     /db_xref="GeneID:84607"
                     /db_xref="RGD:69273"
                     /translation="MTLRCLEPSGNGADRTRSQWGTAGSPEDQSPEAARLAKALRELS
                     QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDG
                     KFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSA
                     PTLQHFCRLSINKCTGTIRGLPLPTRLKDYLEEYKFQV"
     misc_feature    410..634
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O88582.1);
                     Region: Interaction with AREL1.
                     /evidence=ECO:0000250|UniProtKB:O14508"
     misc_feature    410..502
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O88582.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    497..499
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14508; propagated from
                     UniProtKB/Swiss-Prot (O88582.1); phosphorylation site"
     misc_feature    527..835
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; Region: SH2_SOCS2;
                     cd10383"
                     /db_xref="CDD:198246"
     misc_feature    527..835
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; Region: SH2_SOCS2;
                     cd10383"
                     /db_xref="CDD:198246"
     misc_feature    563..565
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14508; propagated from
                     UniProtKB/Swiss-Prot (O88582.1); phosphorylation site"
     misc_feature    order(572..574,626..628,632..634,656..658,695..697)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198246"
     misc_feature    order(572..574,626..628,632..634,656..658,695..697)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198246"
     misc_feature    order(725..727,731..733,794..796)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198246"
     misc_feature    order(725..727,731..733,794..796)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198246"
     misc_feature    881..1003
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    881..1003
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; Region: SOCS;
                     cl02533"
                     /db_xref="CDD:470605"
     misc_feature    order(884..901,917..919,932..934,950..952)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     misc_feature    order(884..901,917..919,932..934,950..952)
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     exon            549..2215
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagacgtt taactcttgc caagtctcgc cgcctctgcg gctcgcgggc cttgggcttc
       61 tcccctgaag catgagcctt tcctccggca gccgccaacg ctgcgcggat cgcggacagt
      121 gcgcgccggg gctccaggcg cgcggcctca agatcccttg cgcccggagc ccggaagctt
      181 gcggcaggcg atctgtgggt gaccgtgtct gcgagagact ttgccatacc attttgcggg
      241 aatttggaga gaaacaacca gctgcttcca gtcccctccc cctccgccac catttcggac
      301 accccgcaca gactcgtttt ggggtaccct gtgacttcca ggaagcacgc gaggtccttt
      361 ggccccagct cgggcgacca cctgtcttgg acgtgttgac tcatctccca tgaccctgcg
      421 gtgcctggag ccctctggga atggcgcgga caggacacgg agccagtggg ggacagcggg
      481 gtcgccggag gatcagtccc cggaggcggc gcgtctggcg aaggccctgc gtgagctcag
      541 tcaaacagga tggtactggg gaagtatgac tgttaatgaa gccaaagaga aattaaaaga
      601 ggcgccagaa ggaactttct tgattagaga tagctcccac tcagactacc tattaaccat
      661 atctgttaag acatcagccg ggccgactaa cctgcggatt gagtaccaag acgggaaatt
      721 cagattggat tctatcatat gtgtcaagtc caagcttaag cagtttgaca gcgtggttca
      781 tctgattgac tactacgttc agatgtgcaa ggacaaacgg acaggccctg aagccccccg
      841 gaatgggact gttcaccttt acctgaccaa acctctgtat acatcagcac cgacgctgca
      901 gcacttctgc cgactcagca ttaacaagtg taccggtacc atccggggac tacctttacc
      961 aacaagactg aaagattact tggaagagta taaattccag gtataagtat ttctctctct
     1021 ctctctctct tttttttttt tttaaatgaa tgcctcatat agagtatcac cgaatgcagc
     1081 tatgtaaaag agaaaacccg gaggccctcc tctgggtaac catgcagaat tctttctcaa
     1141 gcaaggttga gctcagtcta atttaaaggt gtgaagacgt agctaggtat ttttaaagtc
     1201 ccccttaggc agtttcagcc gattgatgct ttctttccta tggctgttca agaccaaatt
     1261 ggcccctttt aaatggaaag caagatgtcc caagggaagg caagagaata accctgtcag
     1321 aactacttac ttgccttttt tttttttttt tttttttggt tctttttttc ggagctgggg
     1381 accgaaccca gggccttgcg cttcctaggt aagcgctcta ccactgagct aaatccccag
     1441 cccccccctt tttttttaac cccaccctgg gtgcctgtgc actgggtcag aagtccaagc
     1501 accataggag agaaagactt ccatgtggat aaggagggag gaaaagaccc tggctgaccc
     1561 aggctccagc tccatttctc ggtgcctggt ggtcagtctg tgctagaaca agttatagtt
     1621 tgcatcccga cgtatctagt aggagttccg ttaggccggt catgcttgta tttatccctt
     1681 gttttatgca attaatcaaa tcaaccaaaa aaaaaaaaag cccatcacca tgagatcctg
     1741 tatttgtctt ttttactaca tgtatgaact cccccgtgaa tgagtactgt agtcatctat
     1801 ttcaaggcag ccttacttta gaaacatttc aaactggtgc aaacaggaaa gacttctctc
     1861 ttttccttta aggctaaaga caagaatgtc acgctacaca ggtgcaactc aatcctcgaa
     1921 aacaaaaaca aaaacaaaac gaaaaccaat gcagacagag acattttacc cctcggcgta
     1981 gctgtgagtc ctaacctatt gccatgacat tttggacatg gctttagaac tttccaagtt
     2041 gtccttgaat tgtctgacca cggacatcaa cagctgcctc ccttctacca tgtagaatac
     2101 tatgacttac tcttcttcca gatatagggg ggtacctgcc tgtttttcaa agtgtttatt
     2161 tactgctgtt actctttgac taggatgtat taaataaaaa caaacctgat tttta
//
LOCUS       NM_001438101            3576 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus proline and serine rich 3 (Proser3), transcript
            variant 6, mRNA.
ACCESSION   NM_001438101 XM_008759168
VERSION     NM_001438101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3576)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_008759168.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.1585.1,
                                           SRR26360186.2789992.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  94933241-94933340   c
            101-191             JAXUCZ010000001.1  94931143-94931233   c
            192-359             JAXUCZ010000001.1  94930658-94930825   c
            360-487             JAXUCZ010000001.1  94928181-94928308   c
            488-588             JAXUCZ010000001.1  94928000-94928100   c
            589-671             JAXUCZ010000001.1  94926045-94926127   c
            672-826             JAXUCZ010000001.1  94925808-94925962   c
            827-1005            JAXUCZ010000001.1  94923695-94923873   c
            1006-1921           JAXUCZ010000001.1  94922695-94923610   c
            1922-2003           JAXUCZ010000001.1  94922525-94922606   c
            2004-3576           JAXUCZ010000001.1  94920802-94922374   c
FEATURES             Location/Qualifiers
     source          1..3576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3576
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
     exon            1..100
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    73..75
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="upstream in-frame stop codon"
     exon            101..191
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2145
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="isoform 2 is encoded by transcript variant 6;
                     proline and serine-rich protein 3; uncharacterized protein
                     C19orf55 homolog"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001425030.1"
                     /db_xref="GeneID:361541"
                     /db_xref="RGD:1565712"
                     /translation="MFPKVDNPLDHQEARTGATRSQKPQAPKATAANSAELSEESWPS
                     SSGTASPPSTTEGQSTSPPLTLIDNEDSVVAKYINRFRKAQPTSREDRQPVGPTPADF
                     WWLQPASSDLSSHLAAGAGEPTGRSAVTGPCPTGMSSTSLASVPLQRVKQSLNSWNSA
                     MLELETLSLQSRAAKLLERSKASLSSSSSSPSPNEASSSSFPISSDGLSPCSVTFNPD
                     SNKSSSPKEPVLGAAPVPSQAIPAPRPASAQATLKPEEDILYQWRQRRKLEQSLQGAG
                     DGTWVLPRTPALTTQTPVSAVNLGSKGTQPNCAPPWGSVAQPPPPQAFYMERPPLSGP
                     SPHIWAPGTHGVLWAPQANPWIPLGMVPTTLLTSTLAPLASLPVPPTSTSAATAPISA
                     PQVSIPGPPASAPPPCTSAPASTVPLPDNPQGPTTPELSSSVHPKKLSPKPRCVSASS
                     RQETTGPDTAAFESPCSQLRGALSQVVTARLFSDSLEDMPPSEADSRKVKATSSQAKV
                     PPPPPESRRGSKTESRKSKVTLSAEAGDPQPATAPKASTLSEVQSLEFKKSTPKKGAG
                     DALTTAPPASSHAPSEDLLSQAARLLQAAEDSDGSEFPEDSVLRVLRAQRAELRQQKR
                     NVDAQLSLLLDHTEDPGFSSPPARSPSSSPRMRLRREGASLEARRP"
     misc_feature    <784..1671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <784..1671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1891..>2025
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     misc_feature    1891..>2025
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; Region: SKA3_N; cd12957"
                     /db_xref="CDD:240570"
     exon            192..359
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            360..487
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            488..588
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            589..671
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            672..826
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1005
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1921
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2003
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..3576
                     /gene="Proser3"
                     /gene_synonym="RGD1565712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacagcg ttgctaagcg aggagggtag gcgcggggct cttcggtgaa gtagctcagc
       61 tggcgctaag gctgaaataa atccgacaga ctgactgcag tcagttttca cctcccaaga
      121 cagcccttgg aaatgttccc caaggtggac aaccctttag accatcaaga agccagaact
      181 ggagccacaa ggtctcaaaa gccacaagct cccaaggcca cagcagccaa ttctgctgag
      241 ctgtctgagg agtcctggcc atccagttca gggaccgctt ccccacccag taccactgag
      301 ggacagagta cctctccacc cctcacctta attgacaacg aggactcagt ggtggccaag
      361 tacataaacc ggttccgcaa agctcagccc acgagccgag aggaccgcca gcccgtgggc
      421 ccaaccccag ctgacttttg gtggctacag cctgcgtctt cagacctcag cagtcacctt
      481 gcagcaggag ctggtgaacc tacaggaaga tctgccgtga caggtccatg tcccaccggg
      541 atgtccagta cgtctctggc ttctgtgcct cttcagagag taaagcagag tctgaactct
      601 tggaactcgg ctatgctgga gctggagacc ctgagccttc aaagccgagc ggccaagctg
      661 ctggaacgca gcaaggcctc cctctcctcc tcctcctcct cccccagtcc caacgaagcc
      721 agcagctcct ccttccccat cagctctgac ggcctctctc cctgctctgt gaccttcaat
      781 ccggactcca acaagagttc tagtcccaaa gaacccgtgc tgggagcagc cccagtgcca
      841 tcccaggcca tccctgcacc ccgcccagcc tctgcccagg caacccttaa gcctgaggaa
      901 gacattttat accaatggag gcaacggagg aagcttgagc agtctctaca aggtgcaggt
      961 gatggaacct gggtgttgcc tcggacacca gccctcacta ctcagactcc tgtctctgca
     1021 gtgaatcttg gttccaaggg gacccaacct aactgtgctc caccatgggg cagtgtggcc
     1081 cagcctcctc ccccacaggc attctatatg gagaggccac ctctttcagg gccctctcca
     1141 cacatctggg cccccggcac acacggggtt ctctgggccc cacaggccaa tccctggata
     1201 cctcttggga tggttcctac cacactgcta acctccaccc ttgctccctt ggcctcctta
     1261 ccagtaccac ctacctccac ttcagctgcc acagccccca tctctgctcc ccaggtctcc
     1321 atcccagggc ccccagcctc tgccccacct ccctgcactt ctgccccagc ttccaccgtc
     1381 ccactacctg acaaccccca gggaccaacc acccctgagt tgagtagctc tgtccatccc
     1441 aagaagctga gccccaagcc tcgctgtgtg agcgcttcgt ctcgtcagga gactactgga
     1501 ccagacactg cagctttcga gagtccctgt tctcagctta ggggggctct gagccaggta
     1561 gtgacagctc ggctgttctc cgacagcctg gaggatatgc ctccatctga agcagattcc
     1621 cggaaagtca aggccacctc ctctcaagcc aaagttccgc cccctccacc tgagtcccgg
     1681 cgtgggtcca agacagagtc ccgcaaaagt aaagtcaccc tctcagctga agctggggat
     1741 ccacagccgg ctacagcccc aaaggcatcc acactgtcag aggtccaatc acttgaattc
     1801 aagaagtcta cacccaagaa gggagctggt gacgccttga ctacggcccc gcctgcctca
     1861 agccacgccc cttccgagga cttgctatcc caggccgcta gacttctgca ggctgcggaa
     1921 gactctgacg gcagcgagtt tccggaagac tctgtgttgc gagtgctaag ggctcagagg
     1981 gcagaactaa ggcagcagaa aaggaatgtg gatgcccaat tatccctcct cttggaccac
     2041 actgaagacc caggattttc atctcctcca gccaggtcac cttccagttc cccaagaatg
     2101 cggttaagga gggaaggagc ctcccttgag gccagacgac cttgaatcat aaacattgtt
     2161 tttcctgggc tggggaggtg gctcagtggg taaagcactt gcaagtgtga agacccgagt
     2221 ttagatcccc agaacccaca taaaggtaac tgacaggcca gctggtccat ggagacaggg
     2281 tctcaatcaa ggtggaaatc aaagaccaat ctctgaaatt ctctgacttc cacacaagag
     2341 ctgtggggtg tggtgcacat aacacaggca cgcacacaca ggcacacaca cacacggacg
     2401 cacacatgcg ctcgcgcacg cacacacaca cacacacaca catacacagg cacacacact
     2461 aaagttgtcc ccaattaata tttttccagt ttactgttaa tctctaagaa atgggttgtt
     2521 gtagaaaggc tgattgtgct aataaggaaa tgtagctctt ccctaactac tgaaacaaag
     2581 tttcttctct ctagccctcc ttcccacccc ctctctctga tatccctccc cctctctctc
     2641 cccgggagca catggctcta ggtaatgtgg gcacctgact tatgcaactc agaagtggag
     2701 ttggacatct cagatggaga caaaggccct gttatgtggc actaagaaac atcagtgttg
     2761 gacaatacat ctctcatctg agctggcatc ctccctctct gatggccgtc tccctccacg
     2821 ggctcacgat gcctcggttc ccacaggtgc ccagattcct ggtgtttccc caagttcgtt
     2881 ctccttcaca ttcttcaaga ctgtgctctc cctactcagg accaaagtcc ttcgacagtt
     2941 agcctgactc ctccccttcc ccacacatag tcaggcgctg actcggtttg ctttatagtt
     3001 ccccagaatc caactccttt ccgctgccct cgcctcagtc taggcttcct cctacctgta
     3061 cagttgaagg ttcgccatta ctataaacac atctgctccc tctttgatgc acttgccacc
     3121 cagggggaca gcctgtctct tctctttgaa actgagcttt tcaacaaatg cacctgaaag
     3181 cctgaggcct ctgtcagaaa catgggttct gtcctcccgt tctttttctt actttctgtg
     3241 actcagatgc ttttcagagt ctgctatgaa acctgattgc tggacacgga aacacacacc
     3301 tgtaatctca ggagtctgag gccagaggat ctcactctgg ggtcaccctc atagtgagtc
     3361 cctgtgttga aaaaaagagt catggggctg gagagatggc tcagtggtta agagcactga
     3421 ctgctcttcc agaggtcctg agttcaattc ccagcaacca catggtggct cacaaccatc
     3481 tgtaatggga tctgatgccc tcttctggtg tgtctgaaga caactacagt gtacttatat
     3541 ataataaata aataaatctt taaaaaagaa agaaaa
//
LOCUS       NM_001437659            5262 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus calcium responsive transcription factor (Carf),
            transcript variant 1, mRNA.
ACCESSION   NM_001437659
VERSION     NM_001437659.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5262)
  AUTHORS   Zheng,F., Zhou,X., Luo,Y., Xiao,H., Wayman,G. and Wang,H.
  TITLE     Regulation of brain-derived neurotrophic factor exon IV
            transcription through calcium responsive elements in cortical
            neurons
  JOURNAL   PLoS One 6 (12), e28441 (2011)
   PUBMED   22174809
REFERENCE   2  (bases 1 to 5262)
  AUTHORS   Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K.,
            Reddel,R.R., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF is a novel protein that cooperates with mouse p19ARF (human
            p14ARF) in activating p53
  JOURNAL   J Biol Chem 277 (40), 37765-37770 (2002)
   PUBMED   12154087
REFERENCE   3  (bases 1 to 5262)
  AUTHORS   Tao,X., West,A.E., Chen,W.G., Corfas,G. and Greenberg,M.E.
  TITLE     A calcium-responsive transcription factor, CaRF, that regulates
            neuronal activity-dependent expression of BDNF
  JOURNAL   Neuron 33 (3), 383-395 (2002)
   PUBMED   11832226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.73747.1,
                                           SRR26360176.1574172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000009.1  68996617-68996660
            45-159              JAXUCZ010000009.1  69003480-69003594
            160-387             JAXUCZ010000009.1  69007733-69007960
            388-448             JAXUCZ010000009.1  69020417-69020477
            449-578             JAXUCZ010000009.1  69021475-69021604
            579-663             JAXUCZ010000009.1  69023524-69023608
            664-853             JAXUCZ010000009.1  69027269-69027458
            854-974             JAXUCZ010000009.1  69030122-69030242
            975-1118            JAXUCZ010000009.1  69032846-69032989
            1119-1352           JAXUCZ010000009.1  69034974-69035207
            1353-1515           JAXUCZ010000009.1  69037446-69037608
            1516-1579           JAXUCZ010000009.1  69039185-69039248
            1580-1710           JAXUCZ010000009.1  69040403-69040533
            1711-2077           JAXUCZ010000009.1  69040880-69041246
            2078-5262           JAXUCZ010000009.1  69043296-69046480
FEATURES             Location/Qualifiers
     source          1..5262
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..5262
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="calcium responsive transcription factor"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
     exon            1..44
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            45..159
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            160..387
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2187
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 8; calcium-response factor; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 8
                     protein"
                     /codon_start=1
                     /product="calcium-responsive transcription factor isoform
                     1"
                     /protein_id="NP_001424588.1"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
                     /translation="MDSGDPSLGQNDPPTILPNTVPETHDPLTSQNIPETLTDTQALH
                     EEQFHLLDQNGQPIQYDLQSLGNSTAQMTGMEQVVIPQESFADVCSPPGVSEEKPIGG
                     SLPAVSTDALEDSASSYSLHSQASLVGPRKSGTRTLEEPLLAPLQPLSCNTPMWACRL
                     RSCEKIGDSYRGYCVSETELESVLTFHKQQTQTVWGTRQSPSPAKPATRLMWKSQYVP
                     YDGIPFVNAGSRAVVMECQYGPRRKGFQLKKISEQESRSCHLYKATCPARIYIKKVQK
                     FPDYRVPTDPQIDRKTIRMEQEKAFTMLKKNLVDAGGVLRWYVQLPTQQAHQYHEPET
                     PGVPLSPSPFPMSPLEEEEAIIRDENCVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQ
                     LRKFVERELFKPDEVPERHNLSFFPTVNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQ
                     WTTDSGNILRETVTVTFAEGNLLKEPITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKI
                     FTHLQALKLQPRLSSPDGSQALVSVNSHPSSSPPGLDTAGNAEANNHSLLLGQSQNLG
                     TDTCLPENSSTASPMGSLPESVQNLVAVDQLVGGEDAEDAGNLEGNVKRTLLGDAHTI
                     PIHILDSHPALVEEDTLSMNQVKQEPNEPTLSTEAKTLLDCKNVSAT"
     misc_feature    772..1470
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     misc_feature    772..1470
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="Amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8; Region: ALS2CR8; pfam15299"
                     /db_xref="CDD:464625"
     exon            388..448
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            449..578
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            579..663
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            664..853
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            854..974
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1118
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1352
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1515
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1579
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1710
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2077
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..5262
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgtggt ggtctccacg gcggggcctc ggagccaaga cgaggtatgg tgagaccaac
       61 agacgaagag acgattgcca ttgggaagac agcccatttt tcacagttct cgaaaggagt
      121 gggcatgctg taccaccaag tgccaacaat aacaccaagc gtctgacctg tatggactct
      181 ggggatcctt cccttggaca aaatgatccc cctaccattt tgcccaatac tgttcctgaa
      241 acacatgatc cactcacatc acagaatata ccagagacac tgactgacac acaggccctt
      301 catgaagagc aatttcatct tttggaccaa aatgggcagc ctattcaata tgaccttcag
      361 tctttgggaa attctactgc acaaatgaca gggatggagc aagtggttat acctcaggag
      421 tcgtttgcag acgtgtgtag tcctccaggt gtctctgaag agaagcccat tggtgggagt
      481 ttgccagctg taagcacaga tgctctagaa gacagcgcca gtagctacag tcttcactca
      541 caagcatccc tcgtgggacc cagaaagtca gggaccagaa ctcttgaaga acctttgctg
      601 gcccctctcc agccactttc ttgtaacaca cccatgtggg cctgccgtct taggagttgt
      661 gagaaaattg gagattccta ccgtggctac tgtgtaagtg agactgaatt agaaagcgtc
      721 ctaacttttc acaagcagca aacacagact gtctggggca ctcgccaatc tccaagccca
      781 gccaaacctg ccacacgctt gatgtggaag tctcagtatg tcccctatga cggcatcccg
      841 tttgtcaatg caggaagtcg agctgttgta atggagtgtc agtatggacc aaggagaaaa
      901 ggttttcagt taaaaaaaat cagcgagcaa gaaagtaggt cttgtcatct ctacaaagct
      961 acttgtccag ccaggatata cattaaaaag gtacagaaat ttcctgacta tagagtacct
     1021 actgaccccc agattgatag gaagacaatc cggatggagc aggagaaagc cttcactatg
     1081 ctgaagaaga acctggtgga cgcgggcggt gtccttcggt ggtatgtgca gttacctacg
     1141 cagcaagctc accagtatca tgaaccagag actcccggtg tccctttgtc accgtcacct
     1201 ttccctatgt ctcctcttga ggaagaggag gctataatca gagatgagaa ctgtgtgttg
     1261 ccctctcgtc tccacccgca agtagcgcat aagatccagg agttagtgtc ccagggagtg
     1321 gggcaagtgt atgcagtgag gaagcagcta agaaaatttg tggaaagaga actgttcaaa
     1381 cctgatgagg tacctgaaag acataattta tctttttttc caactgtaaa tgatatcaaa
     1441 aatcatatcc acgaggtaca gaaatccttg cagactggag atgtggtata taactcagag
     1501 attattccag caacgcttca gtggactaca gatagtggaa atatcctcag agagactgta
     1561 acagttacat ttgcagaagg aaatttacta aaagagccga ttaccagcaa aatggggaca
     1621 agtcagacac aaacttcttt gtctccagaa ccacttccct tgctctcccc actttcttca
     1681 tttcagccca aaatatttac acatttacag gctttgaagt tgcagccaag actctcctct
     1741 cctgatggat cccaggcttt ggtgtcagta aatagccatc catcctccag tccccccggc
     1801 cttgatacgg caggaaatgc tgaagccaat aaccactctc tactgcttgg ccagagtcaa
     1861 aaccttggaa cagacacttg cctacccgag aacagcagca cggcctctcc catgggcagt
     1921 cttccggagt cagttcagaa cctagttgca gtggatcagc tggtgggagg tgaggatgct
     1981 gaggatgctg ggaatctgga aggaaatgta aagaggactc tgttgggaga tgcacacacc
     2041 attccaatac acatcctaga cagccatcca gctcttgttg aagaagatac tctgtccatg
     2101 aaccaagtta aacaagaacc caatgagcca acactgtcta cagaagcaaa gactttgctg
     2161 gactgtaaaa acgtgtctgc tacataaata tttcaagttt ttcagaattt acagatctgg
     2221 ccccttctga tgtcttagaa ggtgaagatt gtcagggcat ggtatatcac tggaccagag
     2281 tggatgatgg gcagttttga cttaaaattc aaatatttgt tgcaaattct atatttgtat
     2341 ttcccttaag aaatatttta ctttattttg tattcctaca atttttttat tattcagtaa
     2401 ggcaagtatt ttaaaagatc atctatctga agttatacat agtaatttag tgtgaacgta
     2461 aatagttata tccagttttg gttcttacaa gacagaaaag accaacaata aagcagtatg
     2521 tgagtgcaca tataggtgtg tcagaaaatt taaagctgtg agaagagttt tgattaacag
     2581 acaggtaaga gaatacttat catctgttta tctggaaaga tagagccata gatttctatg
     2641 gtagcataga gccaccagtc acatccctca atgctgaatt tgcagtttat cctcagtttt
     2701 atatctttaa ctgtaaagga atggtactaa aggtcatctg tcagaaattt cagtgacttg
     2761 gtaagttttg aaaagttgaa ttaatcagat aaataacaca aatcaatgta tttggcatat
     2821 ttttatatgg aattggaggc aaatccctac ctaggaatag aaatataaaa aattcagagt
     2881 attgggggga aaggttagaa ttccctactg tttacagatc atttggggga acttttgatg
     2941 atagcaaaat ttttgttgtt ttttaaatat tcaatttcga ctagaaaata gtttaaatag
     3001 tatttacatt ttttctgtac tagtgttctt actgaattga tagtattaca atttatatat
     3061 ttcaaggtaa gtatatatag cttcaaattt agttcatatt tgaaacatta aaatatctga
     3121 tctgatattt gtttgttaaa taagtacatt tatacttagt accaaataac tagtaaccag
     3181 tatgtttatt ataaagttgt tttcatggaa gagtgactag gtagaaattt caaatgtaac
     3241 tctcatgaaa ttaacctagc tgaagggtag tggtgcacgt ctgtaatccc agcactgagg
     3301 agggagagaa cttggtttgt aaactcagat ttgcctaggc tacatagtga gaccttacta
     3361 agaaagaaag ggggatcacc tacaagattc tttttctgga gattcatttt tgagttatgt
     3421 aaatttttat ttttaaaaat aagaacttaa atggatatta aagtttaata ttcaaagcat
     3481 gaacaatgta attgatacct gaccttgata ctttatgtgg atcgactttc ctaaagtctg
     3541 atttcccatt attattcact ttgctttagg tgtattacct gtacctaaag ataaaacact
     3601 gttattttaa aagtaggcag aactctaaaa ttcattatct ttacatctat atcctagtca
     3661 acataaagtt tattatagcc ctattgaaag caaagttcat atataattac acgtatgatt
     3721 gttaatagga actgcttttc ttttttaaaa gaaagaactg aagatatctg gtgccagtat
     3781 ttatagcagc agacgactaa acctgaatat attatactaa gtttaataca actctagtca
     3841 cttcaaaatc taggttctct tagtctgtgc atacttaaca ggaacaagat caaattagta
     3901 tgtagtttag gactgaatta caggtttcgt tatctgtgtt atagaaactg tttcaagaac
     3961 aggttttcat ctttcaataa tgattatggt ttattactaa atattcactc acagaggaat
     4021 attctcttgg agacattctt tttttatttg gattgctaag gagaaatgct gttaaggaac
     4081 aaactagtca atttctgttg tgtgagggca aggagagaag agcagaggat ctgatggtta
     4141 ctatgtaatc aggaacacat accgtgacat gtgtttctgt cactccactc caccaggcat
     4201 agcggcagac acctttagtt tcagtggatc tctgtgagct ccagggtagc ctggccgaca
     4261 cagtgagatc aggacagcca gagctacata gtgagaccca ggaagaaaga aaaaaaacat
     4321 gtttctgtca cttcattctg tttgaatagg tcttctgtta atatttttta tcatgagaat
     4381 agaaagttac atatattctt cccacaaaca aaaagaaaac agaaaactga acacttaaat
     4441 ccctaattgt atattcttgc atttttttag gtagaaactg gaactattaa tatttttgtg
     4501 tatttaaata agtagttctt aaagatggta tctaataagt ttaaaaattc atttgtcttc
     4561 taaactcatg tgtagtcaca gcgtgtcagt attggccaaa ggtgcttagc atcagtattc
     4621 gaaaactatg tttacatatt taaatgttta attctttaca aatgtaccag atcttaaaca
     4681 caagtgtata aaaatttcag tctctgtatt tggcattcac ttaacaactc cacagcaaac
     4741 tttgatagta ccctttggtt catgtatgac aagatggagt aggagctgag ggggagctgg
     4801 acatttaaaa taagcagtta ggaattcata atcatagcct ggattgtttc tttgtagttt
     4861 tcttgttcaa aacctccaag taaactttgt atatacacca ggaaattatc gatgaaccac
     4921 cacaggagac tttcccccca gtagtaattt tctatgtaag cagccaatgt acttaaaaag
     4981 ctttaacatc ttatgcaaag taaatgtttc ctaaccacca cagaagtgat aggaaacatg
     5041 aactctgggt ccggtattga agtttttaat cttagcccca gcttgtgctt catcttgttt
     5101 ctatcctgtc aaactatata tgtaatcatg tgggtatgag acagtgttta ctttataccg
     5161 ggtttgtaaa aagatttcaa aatgtgtatg tatatattgt aacttgatgt acagtgttct
     5221 tattataatg taatttttta ttaaaaattc tgttttttct ta
//
LOCUS       NM_001438042            6563 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus cell migration inducing hyaluronidase 2 (Cemip2),
            transcript variant 1, mRNA.
ACCESSION   NM_001438042 XM_006231163
VERSION     NM_001438042.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6563)
  AUTHORS   Wu,M., Wang,C., Gong,Y., Huang,Y., Jiang,L., Zhang,M., Gao,R. and
            Dang,B.
  TITLE     Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury
  JOURNAL   Int J Mol Med 52 (6) (2023)
   PUBMED   37888730
  REMARK    GeneRIF: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury.
REFERENCE   2  (bases 1 to 6563)
  AUTHORS   Yamamoto,H., Tobisawa,Y., Inubushi,T., Irie,F., Ohyama,C. and
            Yamaguchi,Y.
  TITLE     A mammalian homolog of the zebrafish transmembrane protein 2
            (TMEM2) is the long-sought-after cell-surface hyaluronidase
  JOURNAL   J Biol Chem 292 (18), 7304-7313 (2017)
   PUBMED   28246172
REFERENCE   3  (bases 1 to 6563)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6563)
  AUTHORS   Zhao,Q., Peng,L., Huang,W., Li,Q., Pei,Y., Yuan,P., Zheng,L.,
            Zhang,Y., Deng,J., Zhong,C., Hu,B., Ding,H., Fang,W., Li,R.,
            Liao,Q., Lin,C., Deng,W., Yan,H., Hou,J., Wu,Q., Xu,T., Liu,J.,
            Hu,L., Peng,T., Chen,S., Lai,K.N., Yuen,M.F., Wang,Y., Maini,M.K.,
            Li,C., Li,M., Wang,J., Zhang,X., Sham,P.C., Wang,J., Gao,Z.L. and
            Wang,Y.
  TITLE     Rare inborn errors associated with chronic hepatitis B virus
            infection
  JOURNAL   Hepatology 56 (5), 1661-1670 (2012)
   PUBMED   22610944
REFERENCE   5  (bases 1 to 6563)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 6563)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231163.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.6263.1,
                                           SRR26643296.4218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAXUCZ010000001.1  228757460-228757899
            441-783             JAXUCZ010000001.1  228772412-228772754
            784-924             JAXUCZ010000001.1  228777206-228777346
            925-1486            JAXUCZ010000001.1  228777734-228778295
            1487-1656           JAXUCZ010000001.1  228781911-228782080
            1657-1845           JAXUCZ010000001.1  228785811-228785999
            1846-2015           JAXUCZ010000001.1  228788159-228788328
            2016-2225           JAXUCZ010000001.1  228788815-228789024
            2226-2431           JAXUCZ010000001.1  228789282-228789487
            2432-2501           JAXUCZ010000001.1  228789621-228789690
            2502-2630           JAXUCZ010000001.1  228792749-228792877
            2631-2719           JAXUCZ010000001.1  228796025-228796113
            2720-2851           JAXUCZ010000001.1  228801689-228801820
            2852-2887           JAXUCZ010000001.1  228802972-228803007
            2888-3043           JAXUCZ010000001.1  228803962-228804117
            3044-3221           JAXUCZ010000001.1  228807517-228807694
            3222-3437           JAXUCZ010000001.1  228809465-228809680
            3438-3646           JAXUCZ010000001.1  228812945-228813153
            3647-3829           JAXUCZ010000001.1  228818638-228818820
            3830-4049           JAXUCZ010000001.1  228821174-228821393
            4050-4148           JAXUCZ010000001.1  228824119-228824217
            4149-4303           JAXUCZ010000001.1  228827926-228828080
            4304-4407           JAXUCZ010000001.1  228831248-228831351
            4408-6563           JAXUCZ010000001.1  228831759-228833914
FEATURES             Location/Qualifiers
     source          1..6563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..6563
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="cell migration inducing hyaluronidase 2"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
     exon            1..440
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..783
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    441..443
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="upstream in-frame stop codon"
     CDS             453..4604
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /EC_number="3.2.1.35"
                     /note="transmembrane protein 2; cell surface
                     hyaluronidase"
                     /codon_start=1
                     /product="inactive cell surface hyaluronidase CEMIP2"
                     /protein_id="NP_001424971.1"
                     /db_xref="GeneID:309400"
                     /db_xref="RGD:1307941"
                     /translation="MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPFRPAPPPKNH
                     ASAKLTSRSQEAPATFAFSPEEQRTPREDRKQKRHKNTFICFAITSFSFFVTLAVILG
                     ISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDMLRLTSDATVNSIVIQDGGLL
                     VFGDDKDGSRNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDEHESMPTFG
                     KKFIGVEAGGTLELHGARRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDT
                     ARVLEHEKFDTHEYHNESRRLQEFLRAQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRL
                     GSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFS
                     VTAYSEWIEGISLSGFRVDIADGVKLHLLDDVSSWGAGDRIVVASTDYSMYQAEELTL
                     LPCPECSRFQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGETEDSCYADNHC
                     QFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHLGRYPVHFHLCGDVDSKGGYRVP
                     TSVNGLSIHHSFSRCITVHGSSGLLIKDTIGFDTLGHCFFLEDGVEQRNILFHNLGLL
                     TKPGTLLPTDRNSSMCTVMRDGVFGNYIPVPTTDCMAVSTFWIAHPNNHLINNAAAGS
                     QDAGIWYLFHKEPTGESSGMQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNS
                     SASDPREYLCLDNSARFRPHQDADPEKPRVAAVIDRLIAFKNNDNGAWVRGGDIIVQN
                     SAFADNGKGLTFASDGSFPSDEGSSQEVSESLFVGESKNYGSQGGQNKYMGTGGIDQK
                     PRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNN
                     VSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYL
                     IRHPNCVSVTKWNAVVCSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAI
                     SPQYQPVVMLEKGYTIHWSGPAPRTTFLYLVNFNKDDWIRVGLCYPSNTSFQVTVGFL
                     QRQNGSLSRIEEYEPAQSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSS
                     QGCERVKIQAATDSKDMSNCMAKAYPQYYKKPSAVKRMPAMLTGFCQGCGTHQMVFSS
                     DPHKSYLPVRFQSPGKAEIQRGEPSVISVNGTDFTFRSAGAFLLIVDACSVPFRLTEK
                     RMFLSADISHLEEYLKASIPPRSIVLLSTRGEIKQMNISDSFVLLGLAKPAHLYNKGS
                     TVFLGFSGNFTPSWTRLFTSPDVQGLGVLEQYLPLQMEEYGCSRTSSVHRRDLELLQQ
                     ALKGL"
     misc_feature    846..1184
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    846..1184
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="G8 domain; Region: G8; pfam10162"
                     /db_xref="CDD:462971"
     misc_feature    1110..1613
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    1110..1613
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; Region: PANDER_like_TMEM2; cd13938"
                     /db_xref="CDD:260112"
     misc_feature    4182..4436
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     misc_feature    4182..4436
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="Interleukin-like EMT inducer; Region: ILEI;
                     pfam15711"
                     /db_xref="CDD:464817"
     exon            784..924
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1486
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1656
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1845
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2015
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2225
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2431
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2501
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2630
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2719
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2851
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2887
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3043
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3221
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3437
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3646
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3829
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..4049
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4148
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4303
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4407
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..6563
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctcggcc cagccgagcc ggcgcttgtg tggccggagg ctgcttaggg gaccctatcg
       61 agccgcggcg cccgccggac cgggacctgc gcggctcggg aacgcgccct gccgctattg
      121 tctcggggcc gcacaagctc gcgccgcccg gacggcgatt cccctcctct tcctccggga
      181 gggaaggatc caagagcgcc aagccgggct ggctggagga ggtggccggg aaggcggagg
      241 gaggagcgtt actccccggc ccgaactgct tctcctacgg cgtaggctgc cgctgaattc
      301 agaccggcag cgggtcgcgg gttcctggtc atggagagga gatctgcacg cggggactcc
      361 aggagctccg ctcccgctcc cgctcctctg gccatcgctt agacacctga gtagaccgac
      421 gctaggaggg ggaggggaag tgacagggta tcatgtatgc ggctggttcc aggggacact
      481 cccctgcttt cctgcaacct caaaacggaa acggccaccg ctcacctggt tatgttcccg
      541 ggaaagtggt tccctttcgg cctgctcctc ctccaaagaa ccacgcctca gccaaactga
      601 cctccaggag ccaagaagcc ccagcaacct ttgctttctc ccccgaggag cagcgaactc
      661 cgagggagga ccgaaagcag aagagacaca agaacacctt catctgcttt gccataacca
      721 gcttctcgtt ttttgtgacg ctcgcagtca ttttgggaat atcctccaaa tatgctccag
      781 atgagaattg tccagatcaa aaccctcgtc tcaggaactg ggatccagga caagattctg
      841 cgaaacacat tgttatcaag gagggggata tgcttcgcct gacctcagat gctacagtga
      901 attctatagt cattcaggat ggaggactgc ttgtgtttgg ggatgacaaa gacggatcca
      961 ggaatataac tttgaggact cgatacatcc tgatacagga tggtggggcg cttcatattg
     1021 gagcagaaaa atgccgctat cgatccaaag cgacaattac cttgtacggc aagtcagacg
     1081 aacatgaaag tatgccaaca tttggcaaga agtttattgg cgtggaggct ggcgggacac
     1141 tggagttaca tggggctcgg aggacatcat ggacgatgct ggcgaggact ctgcattcct
     1201 cgggcttgcc ctttggctcc tacgccttcg aaaaggactt ctcccggggc cttaatgtga
     1261 gggtcattga ccaagacaca gctagagttt tagaacacga gaagtttgac acccatgagt
     1321 accacaacga gagcaggaga cttcaggaat ttttgagagc tcaggatccc ggccgcattg
     1381 ttgctattgc tgttggagat tcagccgtca agagcctgtt acagggaacc atccagatga
     1441 tccaggaccg gttgggaagt aagctgatcc aaggcctggg ctacaggcaa gcttgggctt
     1501 tagttggtgt catcgatggt ggaagttctt cctgcaatga atctgtgaga aactatgaaa
     1561 accacagcac tggtggcaag gccctagcac aaggagaatt ctacaccctg gatggtcaga
     1621 agttctctgt gacagcttac agtgaatgga ttgaaggaat ttccctttcg ggtttccggg
     1681 tggacattgc ggatggagtg aagcttcacc tgttggacga tgtcagcagt tggggagccg
     1741 gagaccggat tgtggttgcg agcaccgact attccatgta ccaggcagag gagctgacgc
     1801 ttctgccctg ccccgagtgc agccgttttc aggtcaaagt taaagagatc ccccagtacc
     1861 tgcacgttgg tgagatcata gacgggatag acatgagagc ggaggttgga cttctcaccc
     1921 ggaacattgt gatccaagga gaaacggagg actcatgcta cgctgataat cactgccagt
     1981 tctttgatta tgacaccttt gggggacatg tcatgataga gaagaatttt acttcagtcc
     2041 atctgtctta tgtggagttg aagcacatgg gccagcagca tctgggacgc tatcctgtgc
     2101 attttcacct gtgtggagat gtggattcta aaggagggta ccgagtgcca acgtctgtga
     2161 acggcctgtc tattcatcac agcttttcaa ggtgcatcac tgtgcacggg tccagtggct
     2221 tgctcatcaa agacaccatt ggattcgaca ccctaggtca ttgcttcttt ttggaagatg
     2281 gtgttgaaca gagaaacatt ttgttccata acctggggct tcttaccaag ccgggcactc
     2341 tcctccccac cgacaggaac agctccatgt gcaccgtcat gcgtgatgga gtgtttggaa
     2401 actacatccc cgtgcctacc acagattgta tggctgtttc aactttctgg attgcccacc
     2461 ccaacaacca tctgatcaat aacgcagctg caggctcaca ggatgctgga atatggtatt
     2521 tattccacaa ggaaccaact ggggaatcca gtggaatgca gctcctggag aagccagaac
     2581 tcacgccact gggaatattt tataacaaca gggttcattc aaattttaag gctggtttat
     2641 ttgttgacaa aggtgtcaaa acgaccaact ccagtgcctc tgacccaagg gagtacctgt
     2701 gtctggataa cagtgcaagg tttcggcccc atcaggatgc agaccctgaa aagccacgag
     2761 ttgcggctgt catcgacaga ctcattgctt ttaaaaacaa tgacaatggt gcctgggtcc
     2821 gaggaggaga cattattgtt cagaattcag catttgcaga taacgggaag gggttgacct
     2881 ttgccagtga tgggagcttc ccaagcgatg aagggtccag ccaggaagtg tcggagtccc
     2941 tctttgtcgg ggagagtaag aattacggct ctcagggtgg ccagaacaag tacatgggca
     3001 cagggggaat agaccagaag cctcggacgc tacctaggaa caggacattc ccaatccgag
     3061 gctttcagat ttatgacggg cctattcatc tcacaaagag cacgttcaaa aaatatgtgc
     3121 caactccaga caggtacagc agcgcaatcg gcttcctcat gaagaattcc tggcagacaa
     3181 cacccaggaa taacgtctct cttgtgaagt ttggtccaca ggtctctctg aacgtcttct
     3241 ttggaaagcc tggcccctgg tttgaggatt gtgagctgga tggtgataag aactccatct
     3301 tccacgacat tgatggctct gtgacaggat acaaggacac ctatgtagga aggatggaca
     3361 actacctgat ccgccatcca aactgtgtca gcgttactaa gtggaatgca gtggtctgca
     3421 gtgggaccta tgcccaggtg tatgttcaga cgtggaacac gccgaatctt agcatgatca
     3481 tcacgcgaga cgaataccca tcccacccaa tggtgcttcg gggcattaac cagcgggcca
     3541 tctccccaca gtaccagcct gtcgtcatgc tggagaaggg ctacaccatc cactggagtg
     3601 gcccagcgcc acgtaccact ttcttgtacc tcgtgaactt caacaaggat gactggatcc
     3661 gggtcggcct ctgttacccg tccaacacga gctttcaggt gaccgtgggc tttctgcagc
     3721 ggcagaacgg ctccttatcc agaatcgagg agtacgagcc tgcgcagtcg atggaggagc
     3781 tgcagaagaa gccgtctgag agaaaattct actttgactc tggcacaggg ttattgtttc
     3841 tgtatctcag agcccacagc cacagagatg gccacagtta ctgttcatct cagggatgtg
     3901 aaagagtcaa gattcaggca gccacagact ccaaagatat gagtaactgc atggccaaag
     3961 cgtacccaca gtattacaag aaaccctcgg cagtcaagcg catgccagcc atgctcaccg
     4021 ggttctgtca aggctgtggc acccaccaga tggtgttcag cagtgaccct cacaagagct
     4081 acctccctgt tcgattccag tcccctggga aagcagaaat tcaacgtgga gaaccatctg
     4141 ttatttccgt caatggtact gactttacct tccggagtgc aggtgccttc ctcctcattg
     4201 tggatgcctg cagtgtgccc ttccggttga cggaaaagcg gatgttcctt tctgcagaca
     4261 tcagtcactt ggaagaatat ctaaaggcta gcatccctcc aaggtcaatc gttctcttga
     4321 gcacaagagg agaaatcaag cagatgaata tctcggattc attcgtgctt ctgggactgg
     4381 ccaagccagc acatctgtac aacaaaggta gtactgtatt tttgggattc agcggaaact
     4441 tcaccccatc gtggactagg ctgttcacca gtcctgatgt gcagggcctc ggggtgctcg
     4501 agcagtatct ccccctgcag atggaggaat atgggtgctc caggaccagc agtgtccaca
     4561 gaagggacct tgaactgtta cagcaggctt tgaaagggct ttaaagactt gcctgtaatt
     4621 taagtgctgg gaaagaaaag aaaatgtgaa ctaacttatt taatttatgg cattttaaga
     4681 caacactgtt aacccgatgg aaccattttc ttgttttgat acagaaggga gagaaagaac
     4741 tcaaagcagt tgcttgagtg ccggtttgtg cactgtggcg ttgtgcaggt gggaaagaac
     4801 ccttttgtct ttgtgaggct gctgagttcg gagagcagtt ctcatgcccc ttctttgata
     4861 agcccatcac gggtgctttc tgtatagtag gatgcaggga gcccaagggc tccccgagct
     4921 cctcagagga cgggctgctg tggcatttca gatacttgaa gtcgaatgct cagtcctgca
     4981 gccaactcca ctggctgccc tgttcagtga tgtctggggc tcatttctgt acagcccaca
     5041 agggttttgt gtgatgccag atccggtttt aagtaacaac tcaggcccag cacatgtcct
     5101 ccttgcctgg tcatgtgccc tttttattca cttgtatact gattacttta gagggttcac
     5161 ctttcaaaga gggaaccata ttgggacaaa agagtttttg aaatcttttt gatctgtgac
     5221 cattgaggaa aaggaaagaa aggaagaaac agcacaaaac tattacttgc ttccaggtct
     5281 gaggttggtg ggactttttc tgcagcttta atccttaacc tgtcttgacc tttaaaatgc
     5341 agagctgaag tgatttactt tcctttaaaa gaagcaagcc acttccaaaa ccgtaaactc
     5401 ctgtcatttg aacttgcaca ggaaagctag gtgtagtggt gctcgccttt gatcacagct
     5461 ctccagaagc aggaggatct ctgtgagttt gaggctagcc tggtctacac agtgagttcc
     5521 gggacagcca gggctaagta gagaaaccct gtctcaaaac aaacaaaaca aaaacaaaac
     5581 aaaacaaaat cgccctgcaa caaaaattaa cttgcaaaag gaaacctgtc cttggttttg
     5641 gttttgtacc tgtgttttgt tgtgtggaat tttttttttt aagcgtctct gctcattgtc
     5701 ctaccagaaa atcccagaga gctcactgct tgctactcca taaatattgt acccaaggaa
     5761 agggatcatg gagtctgtgg atatgagctt ctttgtagcc tttaaaagag ggagtctctc
     5821 tcagtgaata tagctttcaa agacaaggag aaagaactcc gggtcgccca gctctgcttc
     5881 ccctgggctt ttcctcagct agtgcggaca catgtggcaa aggaggctgg ctctgcagcc
     5941 aagagggaag atggatcaga atgctgctgt ggggcgcgaa ggcaggtgga tgagtagcca
     6001 ggcacttcct ggctaacagt agcaactgag tatagaaaag ttcatcttcc tccatggagg
     6061 gccgaggctg atgcctgtgc gttgtgtcca ggagacattc tagaacagct ctgtgacttg
     6121 tgatacttta cagaacatgc tacctcaaag tgctgtgaca aaccatgcgg actgtagtgc
     6181 tcacaggacg ggcacgtgtc tcaatcaaag tttggttatt tgtttatctg ggttttttag
     6241 atgtgggtgt ttttgtttgt ttcttttttc tttctttcgt cctgtttttt tttttttttt
     6301 ttgtacagtg agatcttacc tattaaatat atttagtggg tcatggttcc tgaaggtgat
     6361 tgaattgatt gtgtgtacga atatgtgtgt gtgttttgac ttaaatatat ttggtgtgtg
     6421 ctgttttgga gttcctttta tatatatata tatatatata tatttggaga atggatgcaa
     6481 gtttcaaagc actcagtttt tctgatttta tgtactaata attagggcct aagttaaata
     6541 aataaaaatg tgtgtgcatg taa
//
LOCUS       NM_001437907            1850 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus aladin WD repeat nucleoporin (Aaas), transcript
            variant 3, mRNA.
ACCESSION   NM_001437907 XM_008765704
VERSION     NM_001437907.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Carvalhal,S., Ribeiro,S.A., Arocena,M., Kasciukovic,T., Temme,A.,
            Koehler,K., Huebner,A. and Griffis,E.R.
  TITLE     The nucleoporin ALADIN regulates Aurora A localization to ensure
            robust mitotic spindle formation
  JOURNAL   Mol Biol Cell 26 (19), 3424-3438 (2015)
   PUBMED   26246606
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Huebner,A., Mann,P., Rohde,E., Kaindl,A.M., Witt,M., Verkade,P.,
            Jakubiczka,S., Menschikowski,M., Stoltenburg-Didinger,G. and
            Koehler,K.
  TITLE     Mice lacking the nuclear pore complex protein ALADIN show female
            infertility but fail to develop a phenotype resembling human triple
            A syndrome
  JOURNAL   Mol Cell Biol 26 (5), 1879-1887 (2006)
   PUBMED   16479006
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Brooks,B.P., Kleta,R., Stuart,C., Tuchman,M., Jeong,A.,
            Stergiopoulos,S.G., Bei,T., Bjornson,B., Russell,L., Chanoine,J.P.,
            Tsagarakis,S., Kalsner,L. and Stratakis,C.
  TITLE     Genotypic heterogeneity and clinical phenotype in triple A
            syndrome: a review of the NIH experience 2000-2005
  JOURNAL   Clin Genet 68 (3), 215-221 (2005)
   PUBMED   16098009
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Storr,H.L., Clark,A.J., Priestley,J.V. and Michael,G.J.
  TITLE     Identification of the sites of expression of triple A syndrome mRNA
            in the rat using in situ hybridisation
  JOURNAL   Neuroscience 131 (1), 113-123 (2005)
   PUBMED   15680696
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Cronshaw,J.M. and Matunis,M.J.
  TITLE     The nuclear pore complex protein ALADIN is mislocalized in triple A
            syndrome
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5823-5827 (2003)
   PUBMED   12730363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_008765704.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2439328.1,
                                           SRR26643298.42520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000007.1  135355790-135356096 c
            308-435             JAXUCZ010000007.1  135355309-135355436 c
            436-491             JAXUCZ010000007.1  135351834-135351889 c
            492-583             JAXUCZ010000007.1  135351461-135351552 c
            584-630             JAXUCZ010000007.1  135351293-135351339 c
            631-729             JAXUCZ010000007.1  135350514-135350612 c
            730-873             JAXUCZ010000007.1  135348996-135349139 c
            874-994             JAXUCZ010000007.1  135345069-135345189 c
            995-1119            JAXUCZ010000007.1  135344702-135344826 c
            1120-1180           JAXUCZ010000007.1  135344497-135344557 c
            1181-1271           JAXUCZ010000007.1  135344262-135344352 c
            1272-1365           JAXUCZ010000007.1  135344041-135344134 c
            1366-1433           JAXUCZ010000007.1  135343902-135343969 c
            1434-1515           JAXUCZ010000007.1  135343541-135343622 c
            1516-1600           JAXUCZ010000007.1  135343368-135343452 c
            1601-1850           JAXUCZ010000007.1  135342910-135343159 c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1850
                     /gene="Aaas"
                     /note="aladin WD repeat nucleoporin"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
     exon            1..307
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1825
                     /gene="Aaas"
                     /note="isoform 3 is encoded by transcript variant 3;
                     achalasia, adrenocortical insufficiency, alacrimia
                     (Allgrove, triple-A)"
                     /codon_start=1
                     /product="aladin isoform 3"
                     /protein_id="NP_001424836.1"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
                     /translation="MCSLGLFPPPPPRGQVTLYEHNNELVTGNSYESPPPDFRGQVVG
                     VGDAAVGLQRVWINLPVLHLTKDPLKAPGRLDHGTRAAFIHHREQVWKRCINVWHDVG
                     LFGVLNEIANSEEEVFEWVKTASSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQV
                     TNWSSCCLRVFAWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPL
                     SASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPNGGWLLSA
                     SPVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWT
                     CEGWPTLSGRCQTGCWSPDGKRLLFTVLGEALIYSLSFPEPCGTEKGHVGGAKSATIV
                     ADLSETTIQTPDGEERLGGEAHAMVWDPSGERLAVLMKGNPRVQDGNPVILLFRTRNS
                     PVFELLPCGVIQGEPGAQAQLVSFHPAFNKGALLSVCWSTGRITHIPLYFVNAQFPRF
                     SPVLGRAQEPPAGGGGSVHEVPLFTETSPTSAPWDPLPGLPSAQPHSPHSHL"
     misc_feature    653..763
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    653..763
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    <656..1435
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <656..1435
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    773..913
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    773..913
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1033
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    923..1033
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1055..1168
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1055..1168
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            308..435
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            436..491
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            492..583
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            584..630
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            631..729
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            730..873
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            874..994
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1119
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1180
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1271
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1365
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1433
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1515
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1600
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1850
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttccgt tcagcttcac gcagtagttt gtcctgtacg gctacccgtc cgcatacgaa
       61 tctagcccgg gaactaagat tcaagagagc gcagtcacca gccgggagcc tgtcggttcc
      121 agacaccctc cggactgaca agatgtgctc cctggggttg tttcccccgc cgccgcctag
      181 aggtcaagtc accctgtatg agcacaataa cgagctggtg accggcaaca gctatgagag
      241 cccgcctccc gacttccggg gccaggtggt cggggttggg gatgcggcgg tgggtctcca
      301 gagagtgtgg atcaatcttc ctgtcctaca cctgaccaag gatcccctaa aagctcctgg
      361 gaggctggac catggtacaa gagctgcctt catccatcat cgggagcaag tgtggaagag
      421 gtgcatcaat gtttggcacg atgtgggtct ttttggagtc ctgaatgaaa ttgcaaattc
      481 agaggaagaa gtgtttgagt gggtaaagac agcctccagc tgggccctgg ctctctgtgg
      541 ccgggcctcc tccctccatg gctccttgtt cccacacctc tcactcagga gtgaggatct
      601 gattgctgaa tttgcccaag tcactaactg gtccagctgc tgcttacggg tctttgcctg
      661 gcatcctcac accaacaagt ttgcagtggc cctgctggat gactccatcc gtgtttataa
      721 tgccaacagc actatagttc cctccctgaa gcaccgtcta cagcgaaatg tggcagcact
      781 ggcctggaag cccctcagtg cctctgtctt ggctgtggcc tgccagagct gtattctcat
      841 ctggaccctg gaccccactt ccttatctac gagaccctcc tctggctgcg cccaggtctt
      901 gtctcaccct gggcacacac cagtcaccag cttggcttgg gcccccaatg gggggtggct
      961 gctctcagcc tcaccggtag atgctgttat tctggtatgg gacgtttcaa cagaaacctg
     1021 tgtccccctt ccttggttcc gaggaggagg ggttaccaac ttgctgtggt ccccagatgg
     1081 cagcaaagtc ctggctacaa ctccttccgc tgtctttcga gtctgggagg cccggatgtg
     1141 gacttgtgag gggtggccaa ctctctcagg gcgctgccag actggctgct ggagtccaga
     1201 cggaaaacga ttgttgttca ctgtattggg ggaagcatta atttattcct tgtcattccc
     1261 agaaccatgt ggaacagaga aaggacatgt tggaggtgca aagtcagcca ccatcgtagc
     1321 agatctttct gagacaacaa ttcagacccc agatggagag gagagactcg ggggagaggc
     1381 tcacgccatg gtttgggacc ctagtggtga acgactggct gtgctcatga aaggaaaccc
     1441 acgggttcag gatgggaatc ctgtcatcct cctttttcga actcgaaaca gccccgtgtt
     1501 tgagctgctt ccctgtggtg ttattcaggg ggagccggga gcccaagccc agctcgtcag
     1561 cttccatcct gctttcaaca aaggggcctt gctcagtgtg tgctggtcca caggccgaat
     1621 cacccacatc cctctgtact ttgtcaacgc ccaatttcca cgctttagcc cagtgcttgg
     1681 tcgggcccag gagcccccag ctggaggtgg aggctctgtt catgaagtac cactatttac
     1741 tgagacatca ccaacctctg ccccttggga ccctcttcca ggactaccat ctgctcaacc
     1801 ccactcccct cactcccact tgtaaataaa gtttttcttg tttccactca
//
LOCUS       NM_001437953            2459 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus AT-rich interaction domain 3A (Arid3a),
            transcript variant 1, mRNA.
ACCESSION   NM_001437953 XM_006240904
VERSION     NM_001437953.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Tidwell,J.A., Schmidt,C., Heaton,P., Wilson,V. and Tucker,P.W.
  TITLE     Characterization of a new ARID family transcription factor
            (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated
            immunoglobulin gene transcription
  JOURNAL   Mol Immunol 49 (1-2), 260-272 (2011)
   PUBMED   21955986
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Nixon,J.C., Rajaiya,J. and Webb,C.F.
  TITLE     Mutations in the DNA-binding domain of the transcription factor
            Bright act as dominant negative proteins and interfere with
            immunoglobulin transactivation
  JOURNAL   J Biol Chem 279 (50), 52465-52472 (2004)
   PUBMED   15456761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 11, 2025 this sequence version replaced XM_006240904.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.17388.1,
                                           SRR26643299.29827.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000007.1  10430755-10430915   c
            162-794             JAXUCZ010000007.1  10427109-10427741   c
            795-1110            JAXUCZ010000007.1  10426019-10426334   c
            1111-1183           JAXUCZ010000007.1  10411872-10411944   c
            1184-1367           JAXUCZ010000007.1  10409498-10409681   c
            1368-1615           JAXUCZ010000007.1  10408421-10408668   c
            1616-1912           JAXUCZ010000007.1  10407232-10407528   c
            1913-2011           JAXUCZ010000007.1  10406751-10406849   c
            2012-2459           JAXUCZ010000007.1  10405925-10406372   c
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2459
                     /gene="Arid3a"
                     /note="AT-rich interaction domain 3A"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
     exon            1..161
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            162..794
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    181..183
                     /gene="Arid3a"
                     /note="upstream in-frame stop codon"
     CDS             424..2208
                     /gene="Arid3a"
                     /note="dead ringer homolog 1; AT rich interactive domain
                     3A (Bright like)"
                     /codon_start=1
                     /product="AT-rich interactive domain-containing protein
                     3A"
                     /protein_id="NP_001424882.1"
                     /db_xref="GeneID:314616"
                     /db_xref="RGD:1305299"
                     /translation="MKLQAVMETLIQRQQRARQELEARQPPLPPPPEPAGVQARTTMT
                     DEDREPENARMHRTQMAALAAMRAAAAGLRHPSSPGGSEDEDTAQGGTLSSPALHGSG
                     QEGPGHTEGDGHLMDMGSDDDTKPKWEEQELEELGEEEEEEDEDDFEEEEEDEEEEGL
                     GLPESASLGSAGLFTRKAPPTQTFRGDGGPRMLSGPERLGPGPAHPSHVASQMPPPDH
                     GDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVL
                     VTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPN
                     ELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLSSPKLPVTSLGLAASTNGSSITPT
                     PKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREK
                     LESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDPAVNL
                     TSANGSNSISMSVEMNGIVYTGVLFAQPPPPTPPPASSKGGVSSIGTNNTMGNRTGAS
                     GSAGSSGQVGLAGVSAPTMSSTSNNSLP"
     misc_feature    1072..1470
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    1072..1470
                     /gene="Arid3a"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 3A (ARID3A) and
                     similar proteins; Region: ARID_ARID3A; cd16878"
                     /db_xref="CDD:350642"
     misc_feature    order(1198..1218,1291..1293,1297..1302,1309..1311,
                     1333..1344,1348..1356,1360..1362,1450..1455)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     misc_feature    order(1198..1218,1291..1293,1297..1302,1309..1311,
                     1333..1344,1348..1356,1360..1362,1450..1455)
                     /gene="Arid3a"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350642"
     exon            795..1110
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1183
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1367
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1615
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1912
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2011
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2459
                     /gene="Arid3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatggagat gtagacgcgg cctagagact cggtgaggcg ggtgaccccg gagccaggag
       61 cgtgcgccag gggaaggcca agggggagaa aggccaccgg aggccaccag caggctggac
      121 tctgggcacc cgggcatgcg ccccccgggc caccccgagc ggagtctgca ggtgcttgaa
      181 tgagcccgac accagcctct gcccctgggt gcccgacgta acaacaagga tcccactggt
      241 cgcccctggc atgccccacc agccttcacc ctgagttggc agcccccacc cctgccagcc
      301 gtcaccctgc attgttccgg ctcccccgaa gtccccacgc tgcagtgcgg ccaagacccc
      361 tccccacggg ggccaccccc accaagtgcc cctggtgccc ggggtggccc ggcccgtcgg
      421 gccatgaagc tgcaggcagt gatggagact cttattcaga ggcaacagcg agcccggcag
      481 gaactggagg ctcgacagcc tccactaccc ccaccaccgg agcccgctgg tgtccaggct
      541 cggaccacca tgacagatga ggacagggag cctgagaatg cccgtatgca taggacgcag
      601 atggctgcac tggctgccat gcgggctgct gccgccggct tgagacatcc gtcctctccc
      661 gggggctcgg aggacgaaga cacagcccag ggagggactc tgagttcacc tgccctgcat
      721 ggaagtggcc aggagggacc gggacacact gagggagacg gccatttgat ggacatgggc
      781 tccgatgatg acacgaagcc caagtgggaa gaacaagagc tggaagaact gggggaagag
      841 gaagaggagg aggatgaaga tgactttgag gaagaagagg aggatgagga ggaagaaggc
      901 ctgggcctcc cagagtctgc cagcctgggc tccgcaggcc tgtttacccg caaggcccca
      961 cctactcaga ccttccgtgg agacggtggt cccagaatgc tcagtggccc tgagcgcctg
     1021 ggacctggcc cggcccaccc cagtcatgtg gcgtcccaga tgccaccacc ggaccatggg
     1081 gactggacat ttgaggagca gttcaaacag ctctatgaac tggacgcaga ccccaagagg
     1141 aaagagttcc tggacgacct gttcagcttc atgcagaagc ggggcactcc ggtgaaccgg
     1201 atccccatca tggccaagca ggtcctcgac ctgttcatgc tgtatgtgct ggtgacggaa
     1261 aagggcggtc tggtagaggt tatcaacaag aagctgtgga gggagatcac caaggggctc
     1321 aacctgccca cctccatcac cagtgctgcc ttcacacttc ggacacagta catgaagtat
     1381 ctttacccct atgagtgtga gaggcgaggc ctgagcagcc ccaatgagct ccaggctgcc
     1441 atagacagca accgccggga gggcaggcgc cagagcttcg ggggctccct ctttgcttac
     1501 tcacccagtg gagcccacag catgctgtcc tcacccaagc taccggtgac ttctttgggc
     1561 cttgctgcca gcaccaatgg cagctctatc accccaacac ccaagatcaa gaaagaggaa
     1621 gactcagcca tccccatcac agtcccaggc cgcctacccg tgtctctggc aggccaccct
     1681 gtcgtagcag cccaggcagc ggctgtgcaa gccgcagcag cccaggctgc agttgcggcc
     1741 caggcagccg ccctggaaca actccgggag aagctggaat ccacggagcc tccggaaaag
     1801 aagatggccc tggttgcaga tgagcagcag cgtctcatgc agcgagccgt gcagcagagc
     1861 ttcctggcca tgacagccca gctgcccatg aacatccgga tcaacagcca agcctctgag
     1921 agtcgccagg acccagctgt aaatctcacc agtgccaatg gcagcaacag tattagcatg
     1981 tccgtggaga tgaacggtat tgtatacaca ggggtgctgt tcgctcagcc accacctcct
     2041 acgccacctc ccgcctccag caaaggtggt gtgagcagca ttggtaccaa caacaccatg
     2101 ggtaaccgga caggagccag tggcagtgct ggcagcagcg gccaagtggg gctggctggg
     2161 gtgtctgcac ccaccatgtc ttctacctca aataactcct tgccttaaaa ggaaaccaag
     2221 ttgcatggct gcccacccgc cacaggaacc acatggccac acagggggac ctgggacgtc
     2281 agaagaatcc cagtgggctg ggcagattcc caaggagcca cactgacgcc aaaaaggaga
     2341 gagagagata gagagagaaa gagagagaga gaaaatatat atatatacat atatatatat
     2401 acatatagaa agagataggt agatggagaa acagatctaa taaatcaggg caaagcaaa
//
LOCUS       NM_001438074            3062 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus leucine-rich repeats and death domain containing
            1 (Lrrd1), mRNA.
ACCESSION   NM_001438074 XM_216085
VERSION     NM_001438074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3062)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 15, 2025 this sequence version replaced XM_216085.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3150436.1,
                                           SRR26643293.21698.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000004.1  31247478-31247791   c
            315-2289            JAXUCZ010000004.1  31239517-31241491   c
            2290-2488           JAXUCZ010000004.1  31228525-31228723   c
            2489-2650           JAXUCZ010000004.1  31222230-31222391   c
            2651-2768           JAXUCZ010000004.1  31220437-31220554   c
            2769-3062           JAXUCZ010000004.1  31219568-31219861   c
FEATURES             Location/Qualifiers
     source          1..3062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..3062
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeats and death domain containing 1"
                     /db_xref="GeneID:296836"
                     /db_xref="RGD:1562785"
     exon            1..314
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2289
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    343..345
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="upstream in-frame stop codon"
     CDS             385..2952
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /codon_start=1
                     /product="leucine-rich repeat and death domain-containing
                     protein 1"
                     /protein_id="NP_001425003.1"
                     /db_xref="GeneID:296836"
                     /db_xref="RGD:1562785"
                     /translation="MSEDGSNVEPEGLTRSESLEEPEFIDEISDPSNETSPHSGNTDF
                     NQIYESNSSENTEQPSASSTSQLNGNEETNIEIPFSDTNIEEVIPLSNSESPQSSESS
                     ETNEAEEYHPVKFPIGRKFRGRTFNGHHKGFDMESDTFTVHLDAKGLQEFPVDIVKVK
                     YVKYLYLDKNQIKTFQGADPGDLLGLETLSLQENGLSSIPQEIQLFHNLKVLNASYNE
                     ISHIPKELLQLGNMRQLFLNSNHIESLPSGLENLRYLETLSLGKNRLTHIPDSLCGLK
                     NLKTLNLEYNQLTIFSKSLCFLPKLVSLNLTGNMIGSLPKEVRELKNLENLLMNHNKL
                     TFLAVEIFQLLKIKELHLADNKLEAISPKIENFKELRLLNLDNNLLQSLPKKISHCVN
                     LESLTLSDNNLEELPKKIRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQIT
                     HVPIEIKNCKEITRVELNYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDLSFSKQL
                     LHLELNKNKITIFSEHLCSLTNLEYLDLAKNQIRKIPHCISAMLSLHVLILSDNKFEI
                     FPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKLNLSNNNFTHFPAELCQLQTLE
                     DLNISQISGKKLTRLPEEVSRMTQLKALNISNNAIKEIPRNIGELRNLITFHASNNQI
                     NSLPSSFLSLNVLQSLDLGGNNLTDLPSAIYKLSSLKEINFDDNPLLRPPMEICKGKQ
                     MHTITCYLQRADDRDEKILEKIFHIVANNITETKFEFLQQKLHMARSENSVPVKTTTP
                     LNEGIYQALLKWKTEKRVSFTAIALKDQLFRALNMIGAYDIMDKITALNLYTSAIKL"
     misc_feature    868..939
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    868..939
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    883..1995
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    883..1995
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    940..1008
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    940..1008
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1009..1077
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1009..1077
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1078..1146
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1078..1146
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1147..1215
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1147..1215
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1216..1284
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1216..1284
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1285..1353
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1285..1353
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1354..1422
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1354..1422
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1423..1560
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1423..1560
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1690..2724
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1690..2724
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    1699..1767
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1699..1767
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1771..1836
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1771..1836
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1843..1905
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1843..1905
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1906..1974
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1906..1974
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1975..2043
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    1975..2043
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2044..2112
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2044..2112
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2113..2181
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2113..2181
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2182..2328
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2182..2328
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2329..2397
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2329..2397
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2398..2466
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2398..2466
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2467..2535
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2467..2535
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     exon            2290..2488
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2650
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2768
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..3062
                     /gene="Lrrd1"
                     /gene_synonym="RGD1562785"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaactgagc ctgcgcaacc tccatcgcca caatcacgga cattcgcctc gcgggctcgc
       61 ctcctgcagg cttccgagcg ccacagggag gctctgcgag actgatctaa ggactgctaa
      121 gttctttact tgcctccatc ccctcgcagc accagcacct tcacgccccc ggcccacagc
      181 tcctagtgtt tgcgttctgt cccgtgctgc tttagccgcc aaagctcagc gatcttctcc
      241 ccacaccggt cgaagcaatt tgttaatgtc actaaagtct tgtagttact tggatgtcca
      301 catcgttcag ataggttcaa aggggaaaaa cacacgaaaa agtaaagtta taatctgttc
      361 gtacaagagt tacccgtaaa taagatgtct gaagatggga gtaatgtgga gcctgaagga
      421 ctcactagat ctgagtcact ggaggagcct gaatttattg atgaaatatc agatccctcg
      481 aatgaaacct cacctcactc tggaaataca gatttcaacc agatttatga atcaaattct
      541 tcagagaaca cagaacagcc atcagcttcc tccacaagcc agcttaatgg aaatgaagag
      601 acaaacatag aaattccatt ttcggacact aacatagaag aggtcatccc actgtcaaac
      661 tcagaaagtc cgcagagctc tgagtcatca gagactaacg aggctgaaga atatcaccca
      721 gtcaaattcc caattgggag gaaatttaga ggacgaacct ttaatggaca ccacaaagga
      781 tttgacatgg agtctgatac ctttacagtt catcttgatg ccaagggttt acaagaattc
      841 cctgtagaca ttgttaaagt caaatatgta aaatatttat atttagataa gaatcaaata
      901 aaaactttcc aaggggcaga tccaggtgat ctgctaggac ttgaaactct gtccttgcaa
      961 gaaaatggat tgtcatcgat tccccaggaa attcagttgt ttcacaattt aaaggtacta
     1021 aatgccagtt acaacgagat atcacatatc cctaaagaac tattacaact ggggaatatg
     1081 aggcaactct tcttaaatag taatcatatt gaatctttac cttctggctt agaaaatctt
     1141 agatatttgg aaactttaag tttgggtaaa aataggttaa cacatatacc agactctttg
     1201 tgtggtttga aaaatttgaa aactctcaat ctggaatata accaattaac aatattttct
     1261 aaatcgctat gcttccttcc aaaactcgtt tccctaaacc ttactggaaa catgataggc
     1321 agtttgccaa aagaagttag ggaactgaaa aatttagaaa accttttaat gaatcacaat
     1381 aaacttactt ttttggctgt ggagatattt cagttgctca aaataaaaga acttcatcta
     1441 gctgacaata aattggaagc catttcaccc aaaattgaga atttcaagga actcaggctg
     1501 ctcaaccttg ataacaattt attgcaaagc ttaccaaaga aaatttccca ctgcgtaaac
     1561 ttggaatctc ttactctcag tgataataat ttagaagaac ttcctaagaa aatccgaaag
     1621 cttaaaaatc tgagacaact ccatgcaaac agaaataaaa tgataaaaat ggctgaagaa
     1681 atctcacatc ttagcaagat acacagccta gagttttcag gcaatcaaat cacacatgtt
     1741 cctattgaaa taaaaaactg caaagaaata accagagttg aattgaatta taacaacata
     1801 atgtatttcc cagtggggtt gtgtgcctta cagtcacttg actacttgag ttttaatgga
     1861 aattatattt cagaaatccc tgtggatttg tcattcagta agcagctgct tcatttagag
     1921 ttgaataaaa acaagatcac catattttca gaacatttat gttctctcac taatcttgaa
     1981 tacctggatc ttgctaaaaa tcaaataagg aaaattcctc actgtatctc tgctatgtta
     2041 tcactccatg ttctcattct gtctgataat aagttcgaga ttttcccaaa ggaactgtgt
     2101 tctttaaaaa acttgcaact gcttgatatt tcagaaaatc aattacataa gataccttca
     2161 gaaatatcca aactgaaaaa gatccagaag ttaaacttgt caaacaataa tttcacacat
     2221 tttcctgctg aactgtgcca acttcaaact ctggaggacc tgaatataag tcagataagt
     2281 gggaaaaagt taacaagact tccagaagag gtgtctcgta tgactcaact caaagccctc
     2341 aatatttcga acaatgcaat caaagagatt ccaagaaata taggggagct gagaaatctc
     2401 attacttttc atgcaagcaa caatcaaata aattctcttc catcgtcctt tctgtcttta
     2461 aacgttctac agagcctaga tcttggagga aacaatctga cagatttgcc cagtgctatc
     2521 tacaaacttt catctctgaa agagataaat tttgatgaca atcctttgct gagacctcca
     2581 atggaaatct gtaaaggaaa acagatgcat acaatcactt gctatctcca gagagcagat
     2641 gacagagacg agaaaatctt agagaagata ttccacatag ttgccaacaa tatcactgaa
     2701 acaaaatttg aatttttgca acaaaaacta cacatggcaa ggtcagaaaa cagcgtccct
     2761 gtaaagacca ctactccatt aaatgaagga atctaccagg cattacttaa gtggaaaaca
     2821 gagaagaggg tatcattcac agctattgcc ttaaaagacc aactttttcg ggcactaaat
     2881 atgataggtg cctatgatat aatggacaag atcacagcgt tgaaccttta tacaagcgcc
     2941 atcaaactgt agcgtaaggg atctgaaata gaagctgaaa ccttatcaca cacttacaga
     3001 atggaaatct gacctctggg ctgtttcatt tttgctgata caaggaaatt atttgcatat
     3061 cc
//
LOCUS       NM_001438127            2561 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus MAPK interacting serine/threonine kinase 1
            (Mknk1), transcript variant 1, mRNA.
ACCESSION   NM_001438127 XM_006238698
VERSION     NM_001438127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Panja,D., Kenney,J.W., D'Andrea,L., Zalfa,F., Vedeler,A.,
            Wibrand,K., Fukunaga,R., Bagni,C., Proud,C.G. and Bramham,C.R.
  TITLE     Two-stage translational control of dentate gyrus LTP consolidation
            is mediated by sustained BDNF-TrkB signaling to MNK
  JOURNAL   Cell Rep 9 (4), 1430-1445 (2014)
   PUBMED   25453757
  REMARK    GeneRIF: Long-term potentiation (LTP) consolidation in the dentate
            gyrus of live rodents requires sustained (hours) BDNF-TrkB
            signaling and from TrkB to MAP-kinase-interacting kinase.
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Niknami,M., Patel,M., Witting,P.K. and Dong,Q.
  TITLE     Molecules in focus: cytosolic phospholipase A2-alpha
  JOURNAL   Int J Biochem Cell Biol 41 (5), 994-997 (2009)
   PUBMED   18761105
  REMARK    Review article
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Chrestensen,C.A., Eschenroeder,A., Ross,W.G., Ueda,T.,
            Watanabe-Fukunaga,R., Fukunaga,R. and Sturgill,T.W.
  TITLE     Loss of MNK function sensitizes fibroblasts to serum-withdrawal
            induced apoptosis
  JOURNAL   Genes Cells 12 (10), 1133-1140 (2007)
   PUBMED   17903173
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Origanti,S. and Shantz,L.M.
  TITLE     Ras transformation of RIE-1 cells activates cap-independent
            translation of ornithine decarboxylase: regulation by the
            Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways
  JOURNAL   Cancer Res 67 (10), 4834-4842 (2007)
   PUBMED   17510413
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Chen,S., Atkins,C.M., Liu,C.L., Alonso,O.F., Dietrich,W.D. and
            Hu,B.R.
  TITLE     Alterations in mammalian target of rapamycin signaling pathways
            after traumatic brain injury
  JOURNAL   J Cereb Blood Flow Metab 27 (5), 939-949 (2007)
   PUBMED   16955078
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Chrestensen,C.A., Shuman,J.K., Eschenroeder,A., Worthington,M.,
            Gram,H. and Sturgill,T.W.
  TITLE     MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines
  JOURNAL   J Biol Chem 282 (7), 4243-4252 (2007)
   PUBMED   17130135
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Fukunaga,R. and Hunter,T.
  TITLE     MNK1, a new MAP kinase-activated protein kinase, isolated by a
            novel expression screening method for identifying protein kinase
            substrates
  JOURNAL   EMBO J 16 (8), 1921-1933 (1997)
   PUBMED   9155018
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
  TITLE     Mitogen-activated protein kinases activate the serine/threonine
            kinases Mnk1 and Mnk2
  JOURNAL   EMBO J 16 (8), 1909-1920 (1997)
   PUBMED   9155017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006238698.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.17651.1,
                                           SRR26643429.20406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000005.1  134554954-134555014
            62-109              JAXUCZ010000005.1  134557734-134557781
            110-272             JAXUCZ010000005.1  134563423-134563585
            273-374             JAXUCZ010000005.1  134571567-134571668
            375-472             JAXUCZ010000005.1  134574492-134574589
            473-552             JAXUCZ010000005.1  134578205-134578284
            553-626             JAXUCZ010000005.1  134579770-134579843
            627-731             JAXUCZ010000005.1  134581684-134581788
            732-787             JAXUCZ010000005.1  134585673-134585728
            788-883             JAXUCZ010000005.1  134588565-134588660
            884-1078            JAXUCZ010000005.1  134590071-134590265
            1079-1243           JAXUCZ010000005.1  134590831-134590995
            1244-1287           JAXUCZ010000005.1  134592000-134592043
            1288-2561           JAXUCZ010000005.1  134593119-134594392
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2561
                     /gene="Mknk1"
                     /note="MAPK interacting serine/threonine kinase 1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
     exon            1..61
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..109
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..272
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    224..226
                     /gene="Mknk1"
                     /note="upstream in-frame stop codon"
     exon            273..374
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1516
                     /gene="Mknk1"
                     /EC_number="2.7.11.1"
                     /note="mnk1; MAP kinase signal-integrating kinase 1; MAPK
                     signal-integrating kinase 1; MAP kinase-interacting
                     serine/threonine kinase 1"
                     /codon_start=1
                     /product="MAP kinase-interacting serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_001425056.1"
                     /db_xref="GeneID:500526"
                     /db_xref="RGD:1559603"
                     /translation="MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLG
                     EGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFF
                     EDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTKGIAHRDLK
                     PENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF
                     RDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQ
                     EGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQ
                     VLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEHEALAEGLCSMKLSPPSKSRLA
                     RRRALAHAGREANSCSTPAGL"
     misc_feature    275..352
                     /gene="Mknk1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4G050.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    338..340
                     /gene="Mknk1"
                     /note="Phosphothreonine, by PAK2.
                     /evidence=ECO:0000250|UniProtKB:O08605; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    353..355
                     /gene="Mknk1"
                     /note="Phosphoserine, by PAK2.
                     /evidence=ECO:0000250|UniProtKB:O08605; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    374..1240
                     /gene="Mknk1"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Mitogen-activated protein kinase signal-integrating kinase
                     1; Region: STKc_Mnk1; cd14174"
                     /db_xref="CDD:271076"
     misc_feature    374..1240
                     /gene="Mknk1"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Mitogen-activated protein kinase signal-integrating kinase
                     1; Region: STKc_Mnk1; cd14174"
                     /db_xref="CDD:271076"
     misc_feature    order(401..415,425..427,464..466,470..472,560..562,
                     608..619,629..631,635..637,743..748,752..754,758..763,
                     767..769,806..811,818..820,884..898,902..904)
                     /gene="Mknk1"
                     /note="active site"
                     /db_xref="CDD:271076"
     misc_feature    order(401..415,425..427,464..466,470..472,560..562,
                     608..619,629..631,635..637,743..748,752..754,758..763,
                     767..769,806..811,818..820,884..898,902..904)
                     /gene="Mknk1"
                     /note="active site"
                     /db_xref="CDD:271076"
     misc_feature    order(401..412,425..427,464..466,470..472,560..562,
                     608..619,629..631,758..763,767..769,806..811)
                     /gene="Mknk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(401..412,425..427,464..466,470..472,560..562,
                     608..619,629..631,758..763,767..769,806..811)
                     /gene="Mknk1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(413..415,629..631,635..637,743..748,752..754,
                     758..760,818..820,884..898,902..904)
                     /gene="Mknk1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(413..415,629..631,635..637,743..748,752..754,
                     758..760,818..820,884..898,902..904)
                     /gene="Mknk1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    776..778
                     /gene="Mknk1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    791..793
                     /gene="Mknk1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    806..898
                     /gene="Mknk1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271076"
     misc_feature    806..898
                     /gene="Mknk1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271076"
     misc_feature    863..865
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    878..880
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     misc_feature    order(1028..1030,1040..1042,1064..1066,1073..1075)
                     /gene="Mknk1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    order(1028..1030,1040..1042,1064..1066,1073..1075)
                     /gene="Mknk1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:271076"
     misc_feature    1268..1270
                     /gene="Mknk1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUB5; propagated from
                     UniProtKB/Swiss-Prot (Q4G050.1); phosphorylation site"
     exon            375..472
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..552
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..626
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..731
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..787
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..883
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1078
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1243
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1287
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..2561
                     /gene="Mknk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctcgact gagacctgca ggtgggggtg cgcgcggccg ttcccgcggt ggtcaactaa
       61 gatggactct ctctgggata cccaggctgg catcagttgc taagcacaaa tttccatgct
      121 ggaggagatg aagcagaagc aggcggcaga ctgaagggca ctgactggac agaggccagt
      181 gataactccc tgcggctgga agacaccaac cttgggattc ctctgagatt tcacgttcac
      241 aagtatcact gctgagttga agaaccttgc ggagatgggc agcagtgagc cccttcccat
      301 cgtggatagt gacaagagga gaaagaagaa gcgtaagacc cgggccaccg actctctgcc
      361 agggaagttt gaagacgtgt accagctgac ctcagaattg ctgggagaag gagcctatgc
      421 caaagtccag ggtgccgtga gcctgcagag tggcaaagag tatgcagtca aaatcatcga
      481 gaagcaagca ggacacagtc gaagccgagt attccgtgag gtggagacgt tgtaccagtg
      541 tcaaggaaac aggaacattt tggagctgat tgaattcttt gaagatgaca cacgatttta
      601 cttggtcttt gagaaattgc aaggaggctc catcctagca cacatccaga agcggaagca
      661 cttcaatgag ctagaagcca gcagagtggt gcgggatgtc gccactgccc ttgatttcct
      721 gcatactaaa ggcattgctc accgtgatct gaagccagaa aacatattgt gcgaatctcc
      781 agaaaaggtg tctccggtga aaatttgtga ctttgacttg ggcagtggag taaaattgaa
      841 caactcctgc actcccataa ccacaccaga gctgaccact ccatgcggct ctgcagagta
      901 tatggcacct gaggtggtgg aggtctttag ggacgaggct actttctatg acaagcgctg
      961 tgacctgtgg agcctgggtg tggtcctcta catcatgctg agtggctacc ccccctttgt
     1021 aggtcactgt ggggctgact gcggctggga ccggggagag gtatgcagga tgtgccagaa
     1081 caagctgttc gaaagcatcc aggaaggcaa atacgagttt cccgacaaag actgggctca
     1141 catctccacc gaggccaaag acctcatctc taagctcctg gttcgagatg cgaagcagag
     1201 actcagcgct gcccaagttc tgcagcatcc atgggtgcaa gggcaagctc cagaaagggg
     1261 actccccacg ccgcaagtcc ttcagagaaa cagcagcacc atggacttga cactcttcgc
     1321 agctgaggcc attgccctca accgccagct gtctcagcat gaagagaatg aactggctga
     1381 ggaacacgag gccctagccg agggcctctg ctccatgaag ctgtcccctc catccaaatc
     1441 tcgcctggca cgaaggcgag ccctggccca cgctggccga gaagcaaact cttgttccac
     1501 acccgcaggg ctctgaactg atatgcaggc acaccttgtc ggtgccccct gacaacctac
     1561 gaggtcaaag tgtgaagcta gccgagggac ctgccctgca gccccagcag gcctttacca
     1621 tccacaaagg ctcctgggtt cccacccatc ccccatttcc cttgggtcct caaaggaaaa
     1681 agctttttcc aaaggggttg tctttgaaaa ggaaggcaat cacttgtcac tttgcataat
     1741 agcctgcagc aggaacatct ctctgcccgg ctccaactgc tcccagtgtg cagatcccgg
     1801 atccagcttt tggtgggggc tgctggggct gcagccttca gggagccggc ttccaggagc
     1861 tgacagaagc tgacagacac gcctcttctc ccctgcactg tcaccttctc ccaccttcct
     1921 ctgtcctaca gacgtcctct ctgcctgtct tctccccggc tgagcaaagc catcccctca
     1981 attcaggaag ggcagggaac caaccagatc agtcttccag tctgtagcac ggagaagcac
     2041 ataatctttc tttgccttga ccgagatgtc ttcctcattt atcatcctct tccgtgtttc
     2101 ggattgttgc taaagtcagt attattcctt tttaaaaatg cgtttgcttt atttttaacc
     2161 atgttcttcc agcaaccata gaacttcaaa ctcgcactgt gagcccatgg acttccccag
     2221 gcagatgccc atgcacttgg gttttaatcc tcctccccac tgtctccaac tttaaagacc
     2281 ggtgccttcg catctttgtc tgccactgcc ttctcccagg tcttttgtgg agagaggcac
     2341 aaacccaggg cagtcagact gctgtgtccg agatgaagcc ctgctgccct gctctgagaa
     2401 atgctgtgcc cactgccccc agacatgaag gcacagccac tgtcagataa gctgtggggt
     2461 cacataaaac agatttgcac atgtgacata cgttagtcaa ccacgaccac ccaaattctc
     2521 tcataacttg tgcttatttt aataaataat ttaaaatttt a
//
LOCUS       NM_001438037            5551 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus lysyl oxidase-like 4 (Loxl4), transcript variant
            1, mRNA.
ACCESSION   NM_001438037 XM_006231393
VERSION     NM_001438037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5551)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   2  (bases 1 to 5551)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 5551)
  AUTHORS   Ito,H., Akiyama,H., Iguchi,H., Iyama,K., Miyamoto,M., Ohsawa,K. and
            Nakamura,T.
  TITLE     Molecular cloning and biological activity of a novel lysyl
            oxidase-related gene expressed in cartilage
  JOURNAL   J Biol Chem 276 (26), 24023-24029 (2001)
   PUBMED   11292829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231393.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.5325.1,
                                           SRR21887620.1792440.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000001.1  251365488-251365542 c
            56-351              JAXUCZ010000001.1  251361283-251361578 c
            352-530             JAXUCZ010000001.1  251360597-251360775 c
            531-736             JAXUCZ010000001.1  251359692-251359897 c
            737-775             JAXUCZ010000001.1  251358181-251358219 c
            776-995             JAXUCZ010000001.1  251357820-251358039 c
            996-1179            JAXUCZ010000001.1  251357101-251357284 c
            1180-1334           JAXUCZ010000001.1  251356797-251356951 c
            1335-1502           JAXUCZ010000001.1  251356103-251356270 c
            1503-1665           JAXUCZ010000001.1  251355119-251355281 c
            1666-1909           JAXUCZ010000001.1  251352776-251353019 c
            1910-2025           JAXUCZ010000001.1  251351618-251351733 c
            2026-2162           JAXUCZ010000001.1  251350874-251351010 c
            2163-2274           JAXUCZ010000001.1  251350430-251350541 c
            2275-5551           JAXUCZ010000001.1  251345438-251348714 c
FEATURES             Location/Qualifiers
     source          1..5551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..5551
                     /gene="Loxl4"
                     /note="lysyl oxidase-like 4"
                     /db_xref="GeneID:309380"
                     /db_xref="RGD:1308588"
     exon            1..55
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    3..5
                     /gene="Loxl4"
                     /note="upstream in-frame stop codon"
     exon            56..351
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2345
                     /gene="Loxl4"
                     /EC_number="1.4.3.13"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lysyl oxidase homolog 4"
                     /codon_start=1
                     /product="lysyl oxidase homolog 4 isoform 1 precursor"
                     /protein_id="NP_001424966.1"
                     /db_xref="GeneID:309380"
                     /db_xref="RGD:1308588"
                     /translation="MMWPPPPTFSVFLLLLLSQVPSSRPQSPGTKKLRLVGPANRPEE
                     GRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKFGQGEGPIWLDNVR
                     CLGTEDTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQQGYHSEKVSNALGPQGRRLEEV
                     RLKPILASAKRHSPVTEGAVEVRYEGHWRQVCDQGWTMNNSRVVCGMLGFPSQAPVNS
                     HYYRKVWNLKMKDPKSRLNGLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPA
                     CPGGMHAVVNCVAGPHFQRQKPKPKRKESGAEELKVRLRSGAQVGEGRVEVLMNRQWG
                     TVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYEQTIGDCL
                     ALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGTV
                     CSDHWGLTEAMVTCRQLGLGFANFAIKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQC
                     QRHGPVHCSHGSGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCL
                     SKSADHMDWPYGHRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHY
                     DLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQ
                     WVDITDVSPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDPYRP
                     NAELSLEQEQRLRNNLI"
     sig_peptide     72..146
                     /gene="Loxl4"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    168..470
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    168..470
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    600..932
                     /gene="Loxl4"
                     /note="Scavenger receptor cysteine-rich domain; Region:
                     SRCR; pfam00530"
                     /db_xref="CDD:459844"
     misc_feature    600..932
                     /gene="Loxl4"
                     /note="Scavenger receptor cysteine-rich domain; Region:
                     SRCR; pfam00530"
                     /db_xref="CDD:459844"
     misc_feature    1005..1307
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1005..1307
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1407..1658
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1407..1658
                     /gene="Loxl4"
                     /note="Scavenger receptor Cys-rich; Region: SR;
                     smart00202"
                     /db_xref="CDD:214555"
     misc_feature    1671..2267
                     /gene="Loxl4"
                     /note="Lysyl oxidase; Region: Lysyl_oxidase; pfam01186"
                     /db_xref="CDD:460102"
     misc_feature    1671..2267
                     /gene="Loxl4"
                     /note="Lysyl oxidase; Region: Lysyl_oxidase; pfam01186"
                     /db_xref="CDD:460102"
     exon            352..530
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            531..736
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..775
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            776..995
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1179
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1334
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1502
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1665
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1909
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2025
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2162
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2274
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..5551
                     /gene="Loxl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttagcgctg ctcagccccg gcgcccggcc cagccccgac ctctggatcc agccggtgcc
       61 ccgaagtcac catgatgtgg cccccaccac ccaccttctc cgtgttcctg ctactgctgc
      121 taagccaagt cccctccagc aggccacagt caccaggcac caagaagctc aggcttgtgg
      181 gcccagcgaa caggccagag gagggccggc tggaggtgct gcaccagggc cagtggggta
      241 cagtgtgtga tgatgacttt gctctccagg aggctacagt ggcctgccga caactgggct
      301 ttgagtcagc cttgacctgg gcacacagtg ccaagtttgg ccaaggagag ggccccatct
      361 ggctggacaa tgtccgttgt ttgggcaccg aggacaccct agatcagtgt ggctctaacg
      421 gctggggtgt cagtgactgc agacactcag aagacgttgg ggtggtgtgc catccacggc
      481 gccagcaggg gtatcactct gagaaggtct ccaatgccct cgggccccag ggccggcggc
      541 tagaagaggt gcggctcaaa cccatcctcg ccagtgccaa aaggcacagc ccagtaactg
      601 agggggctgt ggaagtacgg tacgagggcc actggaggca ggtgtgtgac cagggctgga
      661 ccatgaacaa cagcagggtt gtgtgcggga tgctgggctt tcccagtcag gcacctgtca
      721 acagccacta ctacagaaaa gtctggaatc tgaagatgaa ggatcccaag tctagactca
      781 atggcctgac aaagaagaac tccttctgga ttcaccgggt tgactgtttg gggacagaac
      841 cccacttggc caagtgccag gtacaggtgg ctccaggaag aggcaagctc cggccagcct
      901 gtccgggcgg catgcacgct gtggtcaact gtgtggcagg gccgcatttt cagcgacaga
      961 agccaaagcc taagcgcaag gagtctggcg cagaggagct gaaagtgcgc ctgcgctctg
     1021 gggctcaggt gggtgagggc cgtgtggaag tgctcatgaa ccgccagtgg ggcacagtct
     1081 gtgaccacag gtggaacctc atctcagcca gcgttgtgtg tcgccagctt ggctttggct
     1141 ctgcccggga ggcccttttt ggggcccagt tgggccaagg gctagggccc atccacctga
     1201 gtgaagtgcg ctgcaggggc tatgagcaga ccatcggcga ctgccttgcc ctagaagggt
     1261 cccagaatgg ttgtcaacat gcaaatgacg ctgctgtcag gtgcaacatc cctgacatgg
     1321 gcttccagaa caaggtgcgc ttggctggtg ggcgcaactc ggaagagggc gtggtggagg
     1381 tgcaggtgga ggtgaatggg gtcccacgct gggggactgt atgcagtgac cactgggggc
     1441 tcactgaagc catggtgacc tgtcggcaac tcggtctggg atttgccaac tttgctatca
     1501 aggacacctg gtactggcag gggacaccag aggccaaaga agtggtgatg agtggagttc
     1561 gctgctcagg cacagaaatg gcccttcagc agtgtcagag gcatgggcct gtgcactgct
     1621 cccacggctc ggggcgcttc tcggccggcg ttgcctgcat gaacagtgct ccagacctcg
     1681 tgatgaatgc ccagctggta caagaaacgg cctacttgga ggatcgtcca ctcagcatgc
     1741 tgtactgcgc tcatgaggaa aactgtctct ccaagtccgc tgaccacatg gactggccgt
     1801 acggacaccg gcgcttgctg cgcttctcct cacagatcta caaccttggc cgggctgact
     1861 tccgtcccaa ggctggacga cacagctgga tttggcacca gtgccacagg cactaccaca
     1921 gcatcgaggt cttcacccat tatgacctgc tcacactcaa tggttccaaa gtggctgagg
     1981 ggcacaaggc cagcttctgt ctagaagata caaactgccc ctcaggagtg cagcggcgct
     2041 atgcgtgtgc taactttggg gaacagggag tggctgtagg ctgctgggac acctaccggc
     2101 acgacatcga ttgccagtgg gtggatatca cagatgtgag tccaggggac tatatcttcc
     2161 aggtggttgt gaaccccaca aatgatgtgg cagaatcaga cttctccaac aacatgattc
     2221 gatgccgctg caagtatgac gggcagcgag tctggctgca caactgccac acaggagatc
     2281 cctaccgacc caatgcagag ctctccctgg agcaggaaca gcgactcagg aacaacttga
     2341 tctaaagccg ttattgcacg cccccagctc cgctcacaca ccagatacct cagcttactg
     2401 gagccatgcc cttcacaaag ccctgactca caggacaagg ggccagtgac aaggagcacc
     2461 aagaagctgc tcaggaagcc tttcagtggc cagatcatca ccgggatggc agtactctca
     2521 ggacggctct ggcccctcca gagcacttat ggcctagata gcatggcctt gaggctctga
     2581 ccagctaaac cttctcttcc ttaaggagac tcgacctttc ttacaacttg atgcacagtt
     2641 cccagcttca ggagctccaa gttcctcagg gatgaactgt gaccaaggtc ctccctctct
     2701 aagtggtgct tcacaagtgt cttggaggaa cacaggacag aggagcagag aacacaagaa
     2761 gtggatggag tcagtcctct ctgctatgtg ctccatgcaa aataaccatg tcaaagtcac
     2821 acctggcaga gaggctggtg aatgcagtcc ctctgcttat cctccctcag aggctctgaa
     2881 gcctctcctt ggcagtttta ccacacacac acacacacac acacacacgt acatttctaa
     2941 tacccctgaa ccctcaagcc tcctgatgga tcaacatcct gattactggg gctgggggtg
     3001 gtggtggcaa gttacccaga atggcaagac agggcctttc ctgaagagta gcaagaaatc
     3061 aagaagacag ctgaggtcac aagttcagcc tttgaggacc tctgccaagg gagacaacag
     3121 gaagcccata tctggcaggc agtccagtct cttagaatca cctacattgc aaggttagcc
     3181 taaatttcag atttaaccaa ggccacttca ccttaacaaa ctgagaagaa ctgcgataga
     3241 gaagttggtc agtacagccc ctctgcagga acgccaaaac aggtctggta gagttaggaa
     3301 cacaagactg agtcaacaag aagcaagaac gcttaattta gttcaggact gaacctggga
     3361 aaagccacca tccacagaga ggtggctgtg ctctgctttt gctcaactgg tataagatct
     3421 gaagtctttc tgggcatgcc tggacctttt atccatggac gtacacacgg atgtcttcta
     3481 ggtcttataa tccaataaag gctgctcatt atgggctgct acagagacca gagcagctgt
     3541 acttccgtag ctcccagtgc attgcactct gccctcttcc ctccagagct ggatgatacg
     3601 cagaacacat tccttggtac agcccaccct aacctgcttc cctgttacgc tgcccgaggt
     3661 caacagtgat cctcgggtct ggaaggcgag aagtgaaagg gaagaatgag aaggtgcaac
     3721 ccaaagactg taaactttta taatagaggc tacaaaatca aaataaatgg taggagacag
     3781 aactgattta cagtattctc cgccccacat tacaagagct actctgacag tcaagagaca
     3841 tgttttgggg tgccttccgt gaactaaaag tgccttttcc gtctcctccg tcccgtcatc
     3901 cccttcatct ggcacaggaa gcctattctg gtgtaacggt ttaggtaaac aagggaagga
     3961 ctgatttcct gttggatcca gcgaacagtg acatactcac acatgaagct aatggtctgc
     4021 aaaagaatgt gcagctagct agggtggggt ggggtggggt ggtgagtgat gatagacctg
     4081 ggcagggagg ttaccctcac cttcttgttg gatctagttt ccaagaggcc agaaaaagca
     4141 ggccaggcag acagccacca gcactggtct cagctttctg gcccacatca cacgactggt
     4201 aggtgcagcc aattctaatt cctggaaaaa gctatacaag ggctgcgctg ttagacctct
     4261 gagttgaaag ggaaagacac gggaaggttg gtggctggca tgacttatat aacgagatga
     4321 ggaatgttaa cagaatacca accgccaaat tccaggcaga accaaaacct cagaagactt
     4381 tcaccttggc accctgagtg cttcagagaa gggttaggaa gctctcctca gaagctaggc
     4441 taatgctacc aagactttca cgctgtgagg agagaactag aatccacagg aactgtgact
     4501 ttctactaca gatttgacgt aaccctgaga tttagatgtt taccatatac aagacactta
     4561 gtagacggga gtacctgaca tgccgtcccc catagctaac atttctctca cagcagccac
     4621 cctgctctcc ttattttaga gaggtctgtt ctatgggaca gtagcagcca cacggtgctc
     4681 tcccattaac tccttttata aaagttcggt ttagatataa ccaaggattt gatgctatat
     4741 ggacaagctg ggcccatggc tgggacttcg tatcactgac cagtacacag tatccccagc
     4801 tactggaata atttaagcaa aaagcacatt tccaattgga agtaaaacgg caatgcttca
     4861 taactttcaa atgttgactt aaaaaaattg ttctctgagc ctgactagag ttatcctgag
     4921 taatagtagt agctgattac cagatagcta ggttgctaga acactactgt cagaataaaa
     4981 aagaatttgt tttagaaatg agactttttt aaaaactggg taataaacat taacagtgcc
     5041 tttagaagaa gggcatgaag cagttaacaa gaagtccttt cacaggcagg tgacaagagc
     5101 tgctgctttt tttctttttc ttttctcatc ctcaaggtca ctccggacat tgagaagtcc
     5161 agcctgggaa tgtagctcag aggtgaatgc tgtctaacac atgtgtggtc acggtcatgg
     5221 tcttggggta gggtgtgaaa acatggcagg tgtgtgcctt caaagtgtct ctcagtataa
     5281 agccatgctg gggctggagc aatggcttct tccagaggac ccaggtacaa ttcccagcgc
     5341 ccatgtggtg acccataacc agctgtaatt ccagtcccag gagatctaac acacacttct
     5401 ggcctctaca gttaccagga attcagacgt acataaaatt aataataaca gaaaagtaat
     5461 aaagtaacat gtaatataaa ataaatatat ttatactata ttattatatt aataataaac
     5521 aacataaaaa ttaataaaag ccaatactag a
//
LOCUS       NM_017313               2780 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus RAB3A interacting protein (Rab3ip), transcript
            variant 1, mRNA.
ACCESSION   NM_017313 XM_006241357
VERSION     NM_017313.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Vetter,M., Stehle,R., Basquin,C. and Lorentzen,E.
  TITLE     Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3
            and Rabin8 effectors to Rab11
  JOURNAL   Nat Struct Mol Biol 22 (9), 695-702 (2015)
   PUBMED   26258637
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Klip,A., Sun,Y., Chiu,T.T. and Foley,K.P.
  TITLE     Signal transduction meets vesicle traffic: the software and
            hardware of GLUT4 translocation
  JOURNAL   Am J Physiol Cell Physiol 306 (10), C879-C886 (2014)
   PUBMED   24598362
  REMARK    Review article
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Chiba,S., Amagai,Y., Homma,Y., Fukuda,M. and Mizuno,K.
  TITLE     NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by
            switching binding specificity from phosphatidylserine to Sec15
  JOURNAL   EMBO J 32 (6), 874-885 (2013)
   PUBMED   23435566
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Blumer,J., Rey,J., Dehmelt,L., Mazel,T., Wu,Y.W., Bastiaens,P.,
            Goody,R.S. and Itzen,A.
  TITLE     RabGEFs are a major determinant for specific Rab membrane targeting
  JOURNAL   J Cell Biol 200 (3), 287-300 (2013)
   PUBMED   23382462
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Hattula,K., Furuhjelm,J., Arffman,A. and Peranen,J.
  TITLE     A Rab8-specific GDP/GTP exchange factor is involved in actin
            remodeling and polarized membrane transport
  JOURNAL   Mol Biol Cell 13 (9), 3268-3280 (2002)
   PUBMED   12221131
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   de Bruijn,D.R., dos Santos,N.R., Kater-Baats,E., Thijssen,J., van
            den Berk,L., Stap,J., Balemans,M., Schepens,M., Merkx,G. and van
            Kessel,A.G.
  TITLE     The cancer-related protein SSX2 interacts with the human homologue
            of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear
            protein, SSX2IP
  JOURNAL   Genes Chromosomes Cancer 34 (3), 285-298 (2002)
   PUBMED   12007189
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Brondyk,W.H., McKiernan,C.J., Fortner,K.A., Stabila,P., Holz,R.W.
            and Macara,I.G.
  TITLE     Interaction cloning of Rabin3, a novel protein that associates with
            the Ras-like GTPase Rab3A
  JOURNAL   Mol Cell Biol 15 (3), 1137-1143 (1995)
   PUBMED   7532276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 9, 2025 this sequence version replaced
            XM_006241357.5, NM_017313.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.26747.1,
                                           SRR26643297.25083.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000007.1  54461114-54461277   c
            165-444             JAXUCZ010000007.1  54446719-54446998   c
            445-703             JAXUCZ010000007.1  54444976-54445234   c
            704-799             JAXUCZ010000007.1  54436204-54436299   c
            800-877             JAXUCZ010000007.1  54428642-54428719   c
            878-1081            JAXUCZ010000007.1  54427855-54428058   c
            1082-1210           JAXUCZ010000007.1  54425796-54425924   c
            1211-1323           JAXUCZ010000007.1  54424518-54424630   c
            1324-1423           JAXUCZ010000007.1  54420776-54420875   c
            1424-1493           JAXUCZ010000007.1  54420625-54420694   c
            1494-2780           JAXUCZ010000007.1  54417418-54418704   c
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2780
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="RAB3A interacting protein"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
     exon            1..164
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            165..444
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    182..184
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="upstream in-frame stop codon"
     CDS             194..1576
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rab-3A-interacting protein; rabin-3; SSX2-interacting
                     protein; rab3A-interacting protein"
                     /codon_start=1
                     /product="rab-3A-interacting protein isoform 1"
                     /protein_id="NP_059009.2"
                     /db_xref="GeneID:29885"
                     /db_xref="RGD:620650"
                     /translation="MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPH
                     PSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGL
                     TRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYER
                     LKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATA
                     EKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNKSTSSA
                     MSGSHQDFSAIQPIVKDCREADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLT
                     FAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCKHRI
                     KLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSL
                     AKLGYFKEEL"
     misc_feature    482..>913
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    482..>913
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    632..634
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    638..640
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    710..916
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    710..916
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="GDP/GTP exchange factor Sec2p; Region: Sec2p;
                     pfam06428"
                     /db_xref="CDD:428938"
     misc_feature    929..1033
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62739.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    932..934
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    941..943
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    989..1567
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    989..1567
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP); Region: Rab11BD_RAB3IP; cd21068"
                     /db_xref="CDD:411032"
     misc_feature    1007..1009
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    1031..1033
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68EF0; propagated from
                     UniProtKB/Swiss-Prot (Q62739.2); phosphorylation site"
     misc_feature    order(1244..1264,1427..1429,1436..1441,1448..1450,
                     1460..1462,1475..1489)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     misc_feature    order(1244..1264,1427..1429,1436..1441,1448..1450,
                     1460..1462,1475..1489)
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /note="Rab11 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411032"
     exon            445..703
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..799
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..877
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1081
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1210
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1323
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1423
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1493
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2780
                     /gene="Rab3ip"
                     /gene_synonym="RABIN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggctct ccctccctcg gctcccatcg cagtgcgccc gccgcggcgg agtggagcgg
       61 cgtctgtccg ccgccgtcct tcgcgtctcc cgagctgggc acgcgcaccc tgcggctctg
      121 cgagcgccgc tgagcgcggg cggcggccgc ggcgggtccg gcagcttagg ctgtcctatg
      181 atgaagtctt gctatggcta acgacccctt agaaggtttc catgaagtga acctcgcttc
      241 gcctacctct ccagaccttc ttggtgtgtg tgacccggga acccaagagc agactacctc
      301 cccgagcgtc atctaccggc cacacccttc gacgttgtgc tctgccacta tccaggccaa
      361 tgccttaaat ctttctgacc ttcccacaca gcctgtgtat tcatccccga ggcatttaaa
      421 ctgtgcagaa atatctaaca tcagcattca tgttccagag ccagcatcat cggtagcctc
      481 tgaggtggca gcagggctca cgaggttcac ctcaaggaag gacagctgca acgcagagag
      541 ggagtttctg cagggcgcca ccgtcacaga ggcttctgct ggcaacgatg acatctttgg
      601 gttgagcacg gacagcctgt cccgtttacg gagcccatct gttctggaag ttagagagaa
      661 gggctacgaa aggttaaaag aagaacttgc aaaagctcag agggaattga agttaaaaga
      721 tgaagaatgt gagagacttt cgaaagtgcg agatcaactt gggcaggagt tggaagaact
      781 cacagctagt ttatttgagg aagctcacaa gatggtgaga gaggcgaacg tcaagcaggc
      841 aactgcagaa aagcagctga aggaagctca agggaaaatt gatgtgcttc aagccgaagt
      901 ggctgcgctg aagacactcg tactgtccag ttctccaaca tcgcctacgc aggagcctct
      961 ggcggctgga aagacgccct ttaaaagggg gcacacacgg aacaaaagta caagcagtgc
     1021 tatgagtggc agccaccagg acttcagtgc gatccagcca atcgtaaaag actgcagaga
     1081 ggccgatcta tcgctgtata atgagttcag gtcttggaag gatgagccca caatggacag
     1141 aacatgtccc ttcctagaca aaatctatca ggaggatatc tttccatgct taacattcgc
     1201 gaaaagtgag ttggcttcag ctgttctgga ggccgtggag aacaacactc taagcatcga
     1261 gccggtaggg ttgcagccca tccgcttcgt gaaggcttcc gcggtggagt gcggagggcc
     1321 aaaaaagtgt gctctcactg gccagagtaa gccctgtaag cacaggatta aactagggga
     1381 ctccagcagc tattactaca tctctccggt ttgcagatac cggatcactt ctgtatgtaa
     1441 cttttttaca tacattcgat atattcagca gggacttgtg aaacagcagg atgttgatca
     1501 gatgttctgg gaagttatgc aactaagaaa ggagatgtcg ttggcaaagc tgggatattt
     1561 caaagaagaa ctctgatgcc ctgagtacgg ggccgtgcgt gctcctccct ggacagctga
     1621 aggatgacaa cgtttttatg gttactcaat atttatttct aaggagaagg ccaaagactt
     1681 ccctcctctg cacaccacac tatgaagtgc tgtgattttt ttcaaactga ctgagctgta
     1741 cttgcttatc ccttaatgga acacactctg aagattgcag gcctgctagt gatggtaatt
     1801 caacactgca aatccagacc accaaataaa caccagactg aacatgtgtg tctttcttag
     1861 ctctgactcg gcataaagtt gcagaggttg atagtagtct tcacattgta cccctgtgag
     1921 agcgaggaag gagccagctg gacagggctt catgtctgtg tgtatgctgg cattcagacg
     1981 aaaggtttta tttattttta ttctgccagc tgtgatgtag ggaatccttt tatcataatg
     2041 atttgttaag tgtaataaat gaagacagtg aacattcttg ggcatcctga cggagggctt
     2101 cacgttagca ttgagcatta tcgtggaata gaaggagtgt taagtttaat agaccagggc
     2161 atggcctaaa aggatacggt ctgccagctc tgagcttctg gtgactgctt catttctaag
     2221 gttggactaa tgctgacact cgggaagaaa cgaccaacat cagatgtaca aataaaagag
     2281 gttcgtagtg gagacatagt ataggaaagc aaaggaaaac agcccgcttc cttaactcga
     2341 gtaagaacac tccgctcaca cttttggaga acaccttgga ctgtgaaata tttcctactt
     2401 atagatgcac aattctgatt gttgtatgtg tgtgaatgtg tgtgtgtgtg catctcactt
     2461 gggccttgtg cacacagatc tggaactgga gttgcagaca gccgtgagct gccgtctctc
     2521 cagcttgtcc ctctcgcttt aaaagtaaat aatttttcta cattgtatgt gtctatgagg
     2581 gtgtacctgt gtgtgtgtgg cagtcagatg acggctttta ggagtctgtt ctctcctgtc
     2641 taggttttca tgatcaaaca gactcaggac atcagggttg gtagcaatac ctttatgtgc
     2701 tgagccattt ctctggtgcg gatctccaca tcctaatcat tgtgtattca tcgcaattaa
     2761 acatagtcta attgtctcta
//
LOCUS       NM_001106795            1808 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus aladin WD repeat nucleoporin (Aaas), transcript
            variant 1, mRNA.
ACCESSION   NM_001106795 XM_001067255 XM_006242387 XM_217063
VERSION     NM_001106795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Juhlen,R., Landgraf,D., Huebner,A. and Koehler,K.
  TITLE     Identification of a novel putative interaction partner of the
            nucleoporin ALADIN
  JOURNAL   Biol Open 5 (11), 1697-1705 (2016)
   PUBMED   27754849
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Carvalhal,S., Ribeiro,S.A., Arocena,M., Kasciukovic,T., Temme,A.,
            Koehler,K., Huebner,A. and Griffis,E.R.
  TITLE     The nucleoporin ALADIN regulates Aurora A localization to ensure
            robust mitotic spindle formation
  JOURNAL   Mol Biol Cell 26 (19), 3424-3438 (2015)
   PUBMED   26246606
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Huebner,A., Mann,P., Rohde,E., Kaindl,A.M., Witt,M., Verkade,P.,
            Jakubiczka,S., Menschikowski,M., Stoltenburg-Didinger,G. and
            Koehler,K.
  TITLE     Mice lacking the nuclear pore complex protein ALADIN show female
            infertility but fail to develop a phenotype resembling human triple
            A syndrome
  JOURNAL   Mol Cell Biol 26 (5), 1879-1887 (2006)
   PUBMED   16479006
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Brooks,B.P., Kleta,R., Stuart,C., Tuchman,M., Jeong,A.,
            Stergiopoulos,S.G., Bei,T., Bjornson,B., Russell,L., Chanoine,J.P.,
            Tsagarakis,S., Kalsner,L. and Stratakis,C.
  TITLE     Genotypic heterogeneity and clinical phenotype in triple A
            syndrome: a review of the NIH experience 2000-2005
  JOURNAL   Clin Genet 68 (3), 215-221 (2005)
   PUBMED   16098009
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Storr,H.L., Clark,A.J., Priestley,J.V. and Michael,G.J.
  TITLE     Identification of the sites of expression of triple A syndrome mRNA
            in the rat using in situ hybridisation
  JOURNAL   Neuroscience 131 (1), 113-123 (2005)
   PUBMED   15680696
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Cronshaw,J.M. and Matunis,M.J.
  TITLE     The nuclear pore complex protein ALADIN is mislocalized in triple A
            syndrome
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5823-5827 (2003)
   PUBMED   12730363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Apr 11, 2025 this sequence version replaced
            XM_006242387.4, NM_001106795.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3310792.1,
                                           SRR26360186.1616436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000007.1  135355832-135356096 c
            266-393             JAXUCZ010000007.1  135355309-135355436 c
            394-449             JAXUCZ010000007.1  135351834-135351889 c
            450-541             JAXUCZ010000007.1  135351461-135351552 c
            542-588             JAXUCZ010000007.1  135351293-135351339 c
            589-687             JAXUCZ010000007.1  135350514-135350612 c
            688-831             JAXUCZ010000007.1  135348996-135349139 c
            832-952             JAXUCZ010000007.1  135345069-135345189 c
            953-1077            JAXUCZ010000007.1  135344702-135344826 c
            1078-1138           JAXUCZ010000007.1  135344497-135344557 c
            1139-1229           JAXUCZ010000007.1  135344262-135344352 c
            1230-1323           JAXUCZ010000007.1  135344041-135344134 c
            1324-1391           JAXUCZ010000007.1  135343902-135343969 c
            1392-1473           JAXUCZ010000007.1  135343541-135343622 c
            1474-1558           JAXUCZ010000007.1  135343368-135343452 c
            1559-1808           JAXUCZ010000007.1  135342910-135343159 c
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1808
                     /gene="Aaas"
                     /note="aladin WD repeat nucleoporin"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
     exon            1..265
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1783
                     /gene="Aaas"
                     /note="isoform 1 is encoded by transcript variant 1;
                     achalasia, adrenocortical insufficiency, alacrimia
                     (Allgrove, triple-A)"
                     /codon_start=1
                     /product="aladin isoform 1"
                     /protein_id="NP_001100265.1"
                     /db_xref="GeneID:300259"
                     /db_xref="RGD:1308701"
                     /translation="MCSLGLFPPPPPRGQVTLYEHNNELVTGNSYESPPPDFRGQWIN
                     LPVLHLTKDPLKAPGRLDHGTRAAFIHHREQVWKRCINVWHDVGLFGVLNEIANSEEE
                     VFEWVKTASSWALALCGRASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWH
                     PHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCIL
                     IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPNGGWLLSASPVDAVILVWDVST
                     ETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWTCEGWPTLSGRCQTG
                     CWSPDGKRLLFTVLGEALIYSLSFPEPCGTEKGHVGGAKSATIVADLSETTIQTPDGE
                     ERLGGEAHAMVWDPSGERLAVLMKGNPRVQDGNPVILLFRTRNSPVFELLPCGVIQGE
                     PGAQAQLVSFHPAFNKGALLSVCWSTGRITHIPLYFVNAQFPRFSPVLGRAQEPPAGG
                     GGSVHEVPLFTETSPTSAPWDPLPGLPSAQPHSPHSHL"
     misc_feature    611..721
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    611..721
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    <614..1393
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    <614..1393
                     /gene="Aaas"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    731..871
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    731..871
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    881..991
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    881..991
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1013..1126
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1013..1126
                     /gene="Aaas"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     exon            266..393
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            394..449
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            450..541
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            542..588
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            589..687
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            688..831
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            832..952
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1077
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1138
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1229
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1323
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1391
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1473
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1558
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1808
                     /gene="Aaas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttccgt tcagcttcac gcagtagttt gtcctgtacg gctacccgtc cgcatacgaa
       61 tctagcccgg gaactaagat tcaagagagc gcagtcacca gccgggagcc tgtcggttcc
      121 agacaccctc cggactgaca agatgtgctc cctggggttg tttcccccgc cgccgcctag
      181 aggtcaagtc accctgtatg agcacaataa cgagctggtg accggcaaca gctatgagag
      241 cccgcctccc gacttccggg gccagtggat caatcttcct gtcctacacc tgaccaagga
      301 tcccctaaaa gctcctggga ggctggacca tggtacaaga gctgccttca tccatcatcg
      361 ggagcaagtg tggaagaggt gcatcaatgt ttggcacgat gtgggtcttt ttggagtcct
      421 gaatgaaatt gcaaattcag aggaagaagt gtttgagtgg gtaaagacag cctccagctg
      481 ggccctggct ctctgtggcc gggcctcctc cctccatggc tccttgttcc cacacctctc
      541 actcaggagt gaggatctga ttgctgaatt tgcccaagtc actaactggt ccagctgctg
      601 cttacgggtc tttgcctggc atcctcacac caacaagttt gcagtggccc tgctggatga
      661 ctccatccgt gtttataatg ccaacagcac tatagttccc tccctgaagc accgtctaca
      721 gcgaaatgtg gcagcactgg cctggaagcc cctcagtgcc tctgtcttgg ctgtggcctg
      781 ccagagctgt attctcatct ggaccctgga ccccacttcc ttatctacga gaccctcctc
      841 tggctgcgcc caggtcttgt ctcaccctgg gcacacacca gtcaccagct tggcttgggc
      901 ccccaatggg gggtggctgc tctcagcctc accggtagat gctgttattc tggtatggga
      961 cgtttcaaca gaaacctgtg tcccccttcc ttggttccga ggaggagggg ttaccaactt
     1021 gctgtggtcc ccagatggca gcaaagtcct ggctacaact ccttccgctg tctttcgagt
     1081 ctgggaggcc cggatgtgga cttgtgaggg gtggccaact ctctcagggc gctgccagac
     1141 tggctgctgg agtccagacg gaaaacgatt gttgttcact gtattggggg aagcattaat
     1201 ttattccttg tcattcccag aaccatgtgg aacagagaaa ggacatgttg gaggtgcaaa
     1261 gtcagccacc atcgtagcag atctttctga gacaacaatt cagaccccag atggagagga
     1321 gagactcggg ggagaggctc acgccatggt ttgggaccct agtggtgaac gactggctgt
     1381 gctcatgaaa ggaaacccac gggttcagga tgggaatcct gtcatcctcc tttttcgaac
     1441 tcgaaacagc cccgtgtttg agctgcttcc ctgtggtgtt attcaggggg agccgggagc
     1501 ccaagcccag ctcgtcagct tccatcctgc tttcaacaaa ggggccttgc tcagtgtgtg
     1561 ctggtccaca ggccgaatca cccacatccc tctgtacttt gtcaacgccc aatttccacg
     1621 ctttagccca gtgcttggtc gggcccagga gcccccagct ggaggtggag gctctgttca
     1681 tgaagtacca ctatttactg agacatcacc aacctctgcc ccttgggacc ctcttccagg
     1741 actaccatct gctcaacccc actcccctca ctcccacttg taaataaagt ttttcttgtt
     1801 tccactca
//
LOCUS       NM_001438076            7167 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            1 (Sorcs1), transcript variant 1, mRNA.
ACCESSION   NM_001438076 XM_006231520
VERSION     NM_001438076.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7167)
  AUTHORS   Yau,B., Blood,Z., An,Y., Su,Z. and Kebede,M.A.
  TITLE     Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1
            gene results in alternative processing of the Sorcs1 protein in
            INS1 beta-cells
  JOURNAL   Sci Rep 9 (1), 19466 (2019)
   PUBMED   31857633
  REMARK    GeneRIF: Type 2 diabetes-associated single nucleotide polymorphism
            in Sorcs1 gene results in alternative processing of the Sorcs1
            protein in INS1 beta-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7167)
  AUTHORS   Ribeiro,L.F., Verpoort,B., Nys,J., Vennekens,K.M., Wierda,K.D. and
            de Wit,J.
  TITLE     SorCS1-mediated sorting in dendrites maintains neurexin axonal
            surface polarization required for synaptic function
  JOURNAL   PLoS Biol 17 (10), e3000466 (2019)
   PUBMED   31658245
  REMARK    GeneRIF: SorCS1-mediated sorting in dendritic endosomes controls
            Nrxn axonal surface polarization required for proper synapse
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7167)
  AUTHORS   Lazar,J., O'Meara,C.C., Sarkis,A.B., Prisco,S.Z., Xu,H., Fox,C.S.,
            Chen,M.H., Broeckel,U., Arnett,D.K., Moreno,C., Provoost,A.P. and
            Jacob,H.J.
  TITLE     SORCS1 contributes to the development of renal disease in rats and
            humans
  JOURNAL   Physiol Genomics 45 (16), 720-728 (2013)
   PUBMED   23780848
  REMARK    GeneRIF: The experimental data from the rat combined with
            association results from different ethnic groups indicates a role
            for SORCS1 in maintaining proper renal function.
REFERENCE   4  (bases 1 to 7167)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231520.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8487.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-807               JAXUCZ010000001.1  259534929-259535735 c
            808-875             JAXUCZ010000001.1  259355251-259355318 c
            876-975             JAXUCZ010000001.1  259269929-259270028 c
            976-1134            JAXUCZ010000001.1  259220306-259220464 c
            1135-1208           JAXUCZ010000001.1  259199649-259199722 c
            1209-1273           JAXUCZ010000001.1  259175137-259175201 c
            1274-1392           JAXUCZ010000001.1  259148966-259149084 c
            1393-1482           JAXUCZ010000001.1  259146699-259146788 c
            1483-1662           JAXUCZ010000001.1  259140159-259140338 c
            1663-1809           JAXUCZ010000001.1  259128292-259128438 c
            1810-1912           JAXUCZ010000001.1  259112543-259112645 c
            1913-1989           JAXUCZ010000001.1  259112203-259112279 c
            1990-2081           JAXUCZ010000001.1  259110150-259110241 c
            2082-2189           JAXUCZ010000001.1  259107925-259108032 c
            2190-2307           JAXUCZ010000001.1  259106215-259106332 c
            2308-2438           JAXUCZ010000001.1  259104606-259104736 c
            2439-2552           JAXUCZ010000001.1  259101597-259101710 c
            2553-2724           JAXUCZ010000001.1  259088686-259088857 c
            2725-2911           JAXUCZ010000001.1  259067695-259067881 c
            2912-3045           JAXUCZ010000001.1  259059499-259059632 c
            3046-3169           JAXUCZ010000001.1  259057964-259058087 c
            3170-3282           JAXUCZ010000001.1  259052351-259052463 c
            3283-3414           JAXUCZ010000001.1  259051331-259051462 c
            3415-3514           JAXUCZ010000001.1  259044613-259044712 c
            3515-3620           JAXUCZ010000001.1  259031690-259031795 c
            3621-3781           JAXUCZ010000001.1  259031396-259031556 c
            3782-7167           JAXUCZ010000001.1  259026343-259029728 c
FEATURES             Location/Qualifiers
     source          1..7167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..7167
                     /gene="Sorcs1"
                     /note="sortilin-related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
     exon            1..807
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3846
                     /gene="Sorcs1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; VPS10 domain-containing receptor SorCS1; VPS10
                     domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1 isoform
                     1 precursor"
                     /protein_id="NP_001425005.1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
                     /translation="MGKVGAGDGSSAALSALLTGAGLLMLLAPGICSSLSCCPPQHPS
                     STPRWTLTPRGFSYPGPLGRAPATPPPLFMRPLFAVAPGDRALFLERAGGSRVSVATA
                     SRSGRRRRSGMDPEKTEPGEGTSRSRRDMLRDGGQQGPGTGARDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNRFYWSVLGSNKEPDLVHL
                     EARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYV
                     SYRRNPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     ADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELSDSDI
                     SMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGTYAGAMESEPCVCTEADFDCDYGYERHSSG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPT
                     AAELFVLPYQDGARENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKEQELINP
                     VSHTESRPTAPHPDLRRPGQLVDEKVESHLLGSISIVAENQSTKEIPTYVNV"
     sig_peptide     250..348
                     /gene="Sorcs1"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    835..2628
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    835..2628
                     /gene="Sorcs1"
                     /note="VPS10 domain; Region: VPS10; smart00602"
                     /db_xref="CDD:214740"
     misc_feature    2668..2889
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2668..2889
                     /gene="Sorcs1"
                     /note="PKD domain; Region: PKD; pfam00801"
                     /db_xref="CDD:395646"
     misc_feature    2755..>3168
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     misc_feature    2755..>3168
                     /gene="Sorcs1"
                     /note="Uncharacterized conserved protein, PKD repeat
                     domain [Function unknown]; Region: COG3291"
                     /db_xref="CDD:442520"
     exon            808..875
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..975
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1134
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1208
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1273
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1392
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1482
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1662
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1809
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1912
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1989
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2081
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2189
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2307
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2438
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2552
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2724
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2911
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3045
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3169
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3282
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3414
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3514
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3620
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3781
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..7167
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccacccccg cgcagcggcg gcggcggcgg cggtggctcg cagctccgtc ccaacccgcg
       61 cgctcctcac aagcccagcc tgggcgagcg gcaggcacct gcccggcgcc gcctccgcgc
      121 gccccgccgc cgcccaactt ggatggagtt gtggtcctga gcgcacaccc tgccgccgtc
      181 agcccagtgc ctcgctccgc tgcctgcctt cggttcggga ccccctctcc gctcctctcc
      241 gctccagaga tgggaaaagt tggcgccggg gacggctcct cggccgcgct tagcgcgctc
      301 ctaacgggag ccgggcttct gatgctctta gcccctggca tctgcagcag cctttcttgc
      361 tgccctccgc aacaccctag ctcgacccca cgctggaccc ttaccccaag aggcttttct
      421 taccccggac cgctgggtcg ggctcctgcc acgcccccgc ccctcttcat gagacccctg
      481 ttcgcagtgg cccccgggga ccgggcgctg tttctggagc gagctggggg cagcagggtg
      541 tcagtggcga ccgcttcacg ctctggccgt aggagacgga gtggaatgga tcctgagaag
      601 actgaacccg gagagggtac gagtcggagc cgccgggaca tgctaaggga tggagggcag
      661 caggggcctg ggactggcgc gcgggacccg gacaaagcca ctcgcttccg gatggaggag
      721 ctgagattga ccagcaccac atttgcgctg actggagact cggcacacaa ccaagctatg
      781 gtccactggt ctggccacaa cagcagcgtg attctcattt tgacaaagct ctatgactat
      841 aacctgggaa gcatcactga gagctcgctt tggaggtcaa ccgattatgg gacaacctac
      901 gagaagctga atgataaagt ggggttgaag accattttga gctatctcta tgtgtgccca
      961 accaacaagc gtaagattat gctactcacg gacccggaga ttgagagcag tttgttgatc
     1021 agctcagatg aaggggcaac ctatcaaaag taccggctca acttttacat ccagagtttg
     1081 cttttccatc cgaagcaaga agactggatc ctggcctaca gtcaagacca aaagttatac
     1141 agctctgctg agtttggcag aagatggcag cttatccagg aagcagtggt acccaatagg
     1201 ttttactggt ctgtgctggg gtcgaacaaa gaaccagacc ttgtgcatct cgaggccagg
     1261 accgtagatg gtcactccat atacttaact tgtcggatgc aaaactgcac tgaagccaac
     1321 agaaataaac ctttcccagg atacattgac ccggattctt tgattgttca ggatgattat
     1381 gtgtttgttc agctcacatc aggaggaaga ccacattact atgtgtccta ccgaagaaac
     1441 ccatttgcac aaatgaaact tccgaaatat gctttgccca aggatatgca tgtcatcagt
     1501 acggatgaga atcaggtgtt tgcagcagtt caagaatgga accagaatga cacctacaac
     1561 ctgtacatct cagacacacg cggggtctac ttcacgctgg ccttggagaa cgtgcagagc
     1621 agcagaggcc ctgaaggcaa tgtcatgatt gacctttatg aggtagcagg gataaaggga
     1681 atgttcttgg ctaacaagaa gattgacaac caagtgaaga ctttcatcac ttacaacaaa
     1741 ggcagagact ggcgtttgct gcaggctcca gatgcagatc taagggggga ccctgtgcac
     1801 tgtttgctgc cctactgttc actacacctt catctcaaag tttctgagaa tccctacaca
     1861 tctgggatca ttgccagcag agacacagcc ccaagtatta tagttgcatc aggtaacata
     1921 ggctctgagt tgtcagacag cgacatcagc atgtttgtat catcagatgc agggaacact
     1981 tggaggcaga tttttgaaga agagcacagc attttgtacc ttgatcaagg gggagtcctg
     2041 gttgctatga aacacacatc tctcccaatt cggcacctgt ggttgagttt tgatgaaggg
     2101 aggtcttgga gcaaatacag ttttacatcc attccacttt ttgtggatgg agtcctgggg
     2161 gagcctggag aagagacact aatcatgaca gtgtttggac acttcagtca tcgttctgag
     2221 tggcagctgg tcaaagtgga ttacaagtcc atttttgaca gacgctgtgc tgaagaagac
     2281 tacagaccct ggcagttaca tagccagggg gaagcatgca tcatgggagc caagaggatc
     2341 tataagaagc gaaaatctga gcgcaagtgt atgcaaggga cgtatgcagg agcgatggag
     2401 tctgagcctt gtgtgtgtac agaggcggac tttgactgtg actatggcta cgagagacat
     2461 agtagtggac aatgcctacc agcattttgg ttcaacccgt cctcactgtc aaaagactgc
     2521 agcttgggac agagttacct caacagcact gggtacagga aggtggtctc caataactgc
     2581 acggacggag tgagggaaca gtacaccgcc aaaccacaga agtgtccagg gaaggcccct
     2641 cgtgggctac ggattgtcac tgcagatggg aaactgacag cagaacaggg gcacaatgtc
     2701 actctcatgg tgcagttgga agagggggat gtacagcgga cactcatcca agtggacttt
     2761 ggagatggca ttgcggtgtc ttatgtcaac ctcagctcga tggaagacgg aatcaagcat
     2821 gtatatcaga atgtgggcat tttccgagtg accgtgcagg tggacaacag tctggggtct
     2881 gacagcgccg tcctgtactt acatgtaact tgtcccctgg aacatgtgca cctgtccctt
     2941 ccttttgtca caacaaagaa caaagaggtc aacgcaactg ccgtgctgtg gcccagccaa
     3001 gtgggcactc tcacttacgt gtggtggtat gggaacaaca cagagcccct gatcaccttg
     3061 gagggcagca tatcattcaa gtttacttct gaaggaatga acactatcac ggtacaggtc
     3121 tcagctggga atgccatact gcaagacact aagaccattg cggtatacga ggaattccgc
     3181 tctcttcgct tggctttttc tccaaacttg gatgactaca accctgacat cccggagtgg
     3241 aggagggaca tcagccgagt aatcaaaaag tctctggtgg aagccacagg gattcccagc
     3301 cagcatatcc tggtggcagt gttacctggc ttacccactg ctgctgagct ctttgttttg
     3361 ccctatcaag atggagctag agaaaacaaa aggtccccag aggacctgga gcagatatct
     3421 gaagttctaa tccacaaact caaccaaaac ttggtgcact ttgagctgaa gcctggggtc
     3481 caagttcttg tccacgcagc tcacctaaca gcagcccccc tggtggacct cactcctacc
     3541 cacagcggat ctgccatgct gatgttgctc tcagtggtgt ttgtggggtt ggccgtgttc
     3601 gtcatctaca agtttaaaag gaagatcccg gggattaatg tttatgccca gatgcaaaat
     3661 gagaaagaac aagagctgat caatccagtc agccacactg aaagcaggcc cactgcccct
     3721 caccctgacc tcaggaggcc tggccagctt gtagatgaga aggtggaatc ccatctccta
     3781 ggaagtattt ccatagttgc tgagaatcaa agcacaaaag aaatccctac ctatgtaaat
     3841 gtttgaatgg aggacgccag taaaaacaaa caaacaaaaa gtaaataaaa ataaaaacaa
     3901 tcaaaatcca aaataacaag taaacactct cactgcatcg gaacttttaa attcttcaga
     3961 cacagacaac aagggttttt agctttaagc ctgtgcatgt ggacaatact ttgagaacgt
     4021 gtttggaggg gcagtgtaca ggtgctctat tttaatggaa aacactcccc tcctttctca
     4081 tctccttttc tgatcggtca tgtttgtaga aaattcataa catatacagg ccaaggatat
     4141 ctgcatgtat ttttgaaaat attcttggct ctagatttaa cagttctttt agccctaggg
     4201 gctgatggtg gattagccat ccccagcctc ttcctaaaac cacaaagaca tgcacaggat
     4261 gaaaccctga gctgcttctc tgtgttcctt agcgtcacat ttcctttcta agttaatgtt
     4321 agtggctccg ttggtcagca ccgaccacag gctgctttct ctccagtctc tgtggccgca
     4381 gggacaaaga tgctagttaa agattcatac ccatggaggc aggttccata gcaacagaag
     4441 ggaggctggg aagcaaagca tctttgtttc ttgctcaact tttctccttg cagctttccc
     4501 tcttcctacc cccaaggaat gtaaaaaaac aaagacaaaa cacaagtggg attttttccc
     4561 ccagtactta cttggtaccc tactttcaca tttgattgtc atccatgtat gaacatgttc
     4621 tctcgccatc tttcaggttt ttctcctccc tgttccccat tatcttttga tgcctctctc
     4681 tttgtctgct caactgtgtt gctagatttt ggatagtaaa ccttatactt cctaaaactg
     4741 gcccagccta cgccaaccct tactccactc acaagtcttt agctctatca attttgtaca
     4801 atcttaagca tgccagctcc cctgcgttct agccaggctg cgttctgcac agctggcagg
     4861 cttcagttac atttcccctc tatctcctcc ccaaaaacct ttctttgcca aatacctctg
     4921 gttttcccac atggaaacat acactgagtg ttaaagagtt tttacatcca tagtattcca
     4981 aacctggaca tgtgctttgg aaaggaaagc atagagatga gcagtggtgg tttgtgcatt
     5041 aacaaaatct tatgtggtcc aattctagaa gattctcttg agaaaagttt tgaaagtgtg
     5101 actatggtgg aaggtaatat cttctgtgat agttgctgtt atttgatatt tctgctctag
     5161 aataaccata tttgtaaaat aaaactgatt ttaacctcaa ggagaaacag gttaatggac
     5221 ttaatataaa gagtattgaa aaacctatac aaatcggtct tctcatatat ttgaaagaga
     5281 ttttgaccat ttgggatgat ctcattgatt ccaagtatgt actcgaatct tcaattgtca
     5341 cagtattgat gaagaaaaat tcagtataaa tggaagggta actgcttaca gcaaagtaag
     5401 gcttacccct atcatggctt tgaagcaaaa gaaaaccagt ttccctagag gaatcatgca
     5461 agaggctcac aaaaaaggag cagggctcct gctgaagttc ttctagtgac tgagttcccc
     5521 ttcattactg tgtactaaaa aaatcccaat ctcaagttgg gatgaaagtg gtaaaccact
     5581 tccagaacct accatccctt ggctatgtcc caaagccaag aacagggtat tgtcaagggc
     5641 cttggtatat cccaatgatc agtatgatcc tggctcttga atggctgatt cagcgatcag
     5701 gtgactttgc cttatatggc tgaagcaaag ggagaggagg aaagctggtg gtgtcagagg
     5761 ttaatcaaac agaaagctta tggtcgaagg tgccccatgt caatatggtc aattttgcct
     5821 ggggacataa tcaatcaatt ctcaaactgc caggcttcct atctcatagg aaacatcttc
     5881 agtgattatt ctcttcagtt gaagtcttcc atatttagtc tggaagacaa aaatatttgg
     5941 aaaccaaaat aggtccattc aaaccagcac agggaatcct cagcgttgca gttcaattga
     6001 ttctaatttt aaaaaaaaaa atattttaaa aaatgaacaa cattcttgat ctagcacagt
     6061 gccttgccta gaataacatt ttgaaaattt gtttgtcaat aaaaggacaa tgagtgggtg
     6121 aagagacatg gggaagaagg gtctgtaagt cttcatgtaa aatagagatg ggcctgaaat
     6181 tcctgccatc ttgggcagta cccaaagtgg tcagctatag attcagcttc tccagtgtcc
     6241 tcatgtgcct ttcctcaaag ctccctctca cctgtaggtt ggtgaggcaa ggtacttctt
     6301 agagaggacc tacaagtccc tataaccttg gcttgtggat ctcaaagtgt gatgcctaag
     6361 acaagataag agtgtcactt acacttgctt gaaacgcaga ttcaaactgg gctaaaaaca
     6421 gaccctgcta ttttggaaat tctagggatc tttagtatta ttttttgatt atgaatcatg
     6481 gctgtcccaa ccaaatgttt caccaagcca tccaggtgat gatgatacct atgctcaagt
     6541 ttgagaacca ccacactagg ccttgcagcc aaatcccaac aagaaaggaa catttagaac
     6601 ctacaagtgg gacagaacca agtgcctacc tctcactaaa agcaggtgca aacacaatga
     6661 ggactttggt ggatttaagg ccaaaggagt gtagggagga atccatagaa ggtaagattc
     6721 agggcaagct acaaattgga tactgcaacc tctcttaaat gtccaaaggg caaaccgtac
     6781 atgctctacc ctcaacttcc cactaacgtc gtttcccccc ttgcctcatt ctaattggat
     6841 tcgaggtcca aattgcagag gtttgctttg ctttttcctc agaagttcca aacagcaact
     6901 ttgaaagcaa tggggtgctt ggcagcagcc gttgtgtgtt gtcccggatc ccagctgagc
     6961 attgagaccc cttcatttgc caacttcttt ttataggaag ccaattaaaa aaacatatga
     7021 aagttttctt ataggattgg aactacttct aattttaaaa tgactttttt gatgtatttt
     7081 tttgttaaat actatgtagt gtaatgtata attgctcttg tttattgctt ttacaatcat
     7141 atttattaaa cagataatgt ctctaaa
//
LOCUS       NM_001438095            1049 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit B (Atp6v0b),
            mRNA.
ACCESSION   NM_001438095
VERSION     NM_001438095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Nishi,T., Kawasaki-Nishi,S. and Forgac,M.
  TITLE     Expression and localization of the mouse homologue of the yeast
            V-ATPase 21-kDa Subunit c' (Vma16p)
  JOURNAL   J Biol Chem 276 (36), 34122-34130 (2001)
   PUBMED   11441017
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Sun-Wada,G.H., Murakami,H., Nakai,H., Wada,Y. and Futai,M.
  TITLE     Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar
            proton translocating ATPase
  JOURNAL   Gene 274 (1-2), 93-99 (2001)
   PUBMED   11675001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159422.1, FQ225932.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16676786,
                                           SAMN16676787 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000005.1  136711682-136711893 c
            213-261             JAXUCZ010000005.1  136711119-136711167 c
            262-345             JAXUCZ010000005.1  136710825-136710908 c
            346-423             JAXUCZ010000005.1  136710618-136710695 c
            424-493             JAXUCZ010000005.1  136710353-136710422 c
            494-545             JAXUCZ010000005.1  136710177-136710228 c
            546-736             JAXUCZ010000005.1  136709716-136709906 c
            737-1049            JAXUCZ010000005.1  136708822-136709134 c
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1049
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /note="ATPase H+ transporting V0 subunit B"
                     /db_xref="GeneID:298451"
                     /db_xref="RGD:1308303"
     exon            1..212
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..763
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 21kDa, V0
                     subunit b; ATPase, H+ transporting, lysosomal V0 subunit
                     B-like 1; V-type proton ATPase 21 kDa proteolipid subunit
                     c"
                     /codon_start=1
                     /product="V-type proton ATPase 21 kDa proteolipid subunit
                     c''"
                     /protein_id="NP_001425024.1"
                     /db_xref="GeneID:298451"
                     /db_xref="RGD:1308303"
                     /translation="MTGLELLYLGIFVAFWACMIVVGICYTIFDLGFRFDVAWFLTET
                     SPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAI
                     YGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGS
                     GAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD"
     misc_feature    290..478
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /note="V-type proton ATPase 21 kDa proteolipid subunit
                     (ATP6F/ATP6V0B) and similar proteins; Region:
                     ATP-synt_Vo_c_ATP6F_rpt1; cd18177"
                     /db_xref="CDD:349417"
     misc_feature    290..478
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /note="V-type proton ATPase 21 kDa proteolipid subunit
                     (ATP6F/ATP6V0B) and similar proteins; Region:
                     ATP-synt_Vo_c_ATP6F_rpt1; cd18177"
                     /db_xref="CDD:349417"
     misc_feature    542..736
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /note="V-type proton ATPase 21 kDa proteolipid subunit
                     (ATP6F/ATP6V0B) and similar proteins; Region:
                     ATP-synt_Vo_c_ATP6F_rpt2; cd18178"
                     /db_xref="CDD:349418"
     misc_feature    542..736
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /note="V-type proton ATPase 21 kDa proteolipid subunit
                     (ATP6F/ATP6V0B) and similar proteins; Region:
                     ATP-synt_Vo_c_ATP6F_rpt2; cd18178"
                     /db_xref="CDD:349418"
     exon            213..261
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..345
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..423
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..493
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..545
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..736
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1049
                     /gene="Atp6v0b"
                     /gene_synonym="Atp6v0bl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgcgcg ggagtcacgt ggaaccggcg catcacatgc gccggtcagg tggcgctgcg
       61 gggcgggtcg acagactgcg gggcggacgg tggacgcggt tttagctcag gttccaccga
      121 tccgacccct gccgtcgctg ctgccatgac ggggctggag ttgctctacc tcgggatttt
      181 tgtggccttc tgggcctgca tgatcgtcgt gggaatctgc tacaccatct ttgacctggg
      241 ctttcgcttt gatgtggcat ggttcctgac ggaaacttcc cccttcatgt ggtcgaatct
      301 gggcattggc ctagcaattt ccctgtctgt ggttggagca gcctggggaa tctatattac
      361 cggttcttcc atcattgggg gtggggtgaa agcccccaga atcaagacca agaacttggt
      421 tagcattatc ttctgtgaag cagtggccat ttatggcatc atcatggcaa ttgtcatcag
      481 caacatggca gagcctttca gtgctactga ccccaaggcc attggccatc gaaactacca
      541 cgcaggctac tccatgtttg gggctggcct cacagtcggt ctgtccaacc tgttctgtgg
      601 agtctgcgtg ggcattgtgg gcagtggggc tgccctggct gacgcacaga accccagcct
      661 ctttgtaaaa attctcatcg tggagatctt tggcagtgcc attggcctct ttggggtcat
      721 cgtcgcaatc cttcagacct ccagagtgaa gatgggtgac tagatgacct gtatgggtgg
      781 ggccgtgccc cactgttatt tattgctggt tttcctggga tggctggagc tgtgtccctt
      841 agcctttctg gggcttggtg ttcagggccc tcctgcactc acctcttgct gcctgttgac
      901 tttggaggca ttgcagtcca gactgaatcc cagtgtggga agtgggctac tgatggtgac
      961 tgtgtacagc tgtgcgccca tgccccccaa cccccatcca gcccatcttc ttagtgtttg
     1021 tgaaataaac ttggtatttg tcccagtca
//
LOCUS       NM_001438065            6403 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus golgi brefeldin A resistant guanine nucleotide
            exchange factor 1 (Gbf1), transcript variant 6, mRNA.
ACCESSION   NM_001438065 XM_006231502
VERSION     NM_001438065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6403)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6403)
  AUTHORS   Lowery,J., Szul,T., Styers,M., Holloway,Z., Oorschot,V.,
            Klumperman,J. and Sztul,E.
  TITLE     The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane
            recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to
            the trans-Golgi network (TGN)
  JOURNAL   J Biol Chem 288 (16), 11532-11545 (2013)
   PUBMED   23386609
REFERENCE   3  (bases 1 to 6403)
  AUTHORS   Mao,L., Li,N., Guo,Y., Xu,X., Gao,L., Xu,Y., Zhou,L. and Liu,W.
  TITLE     AMPK phosphorylates GBF1 for mitotic Golgi disassembly
  JOURNAL   J Cell Sci 126 (Pt 6), 1498-1505 (2013)
   PUBMED   23418352
REFERENCE   4  (bases 1 to 6403)
  AUTHORS   Mazaki,Y., Nishimura,Y. and Sabe,H.
  TITLE     GBF1 bears a novel phosphatidylinositol-phosphate binding module,
            BP3K, to link PI3Kgamma activity with Arf1 activation involved in
            GPCR-mediated neutrophil chemotaxis and superoxide production
  JOURNAL   Mol Biol Cell 23 (13), 2457-2467 (2012)
   PUBMED   22573891
REFERENCE   5  (bases 1 to 6403)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6403)
  AUTHORS   Szul,T., Grabski,R., Lyons,S., Morohashi,Y., Shestopal,S., Lowe,M.
            and Sztul,E.
  TITLE     Dissecting the role of the ARF guanine nucleotide exchange factor
            GBF1 in Golgi biogenesis and protein trafficking
  JOURNAL   J Cell Sci 120 (Pt 22), 3929-3940 (2007)
   PUBMED   17956946
REFERENCE   7  (bases 1 to 6403)
  AUTHORS   Garcia-Mata,R., Szul,T., Alvarez,C. and Sztul,E.
  TITLE     ADP-ribosylation factor/COPI-dependent events at the endoplasmic
            reticulum-Golgi interface are regulated by the guanine nucleotide
            exchange factor GBF1
  JOURNAL   Mol Biol Cell 14 (6), 2250-2261 (2003)
   PUBMED   12808027
REFERENCE   8  (bases 1 to 6403)
  AUTHORS   Kawamoto,K., Yoshida,Y., Tamaki,H., Torii,S., Shinotsuka,C.,
            Yamashina,S. and Nakayama,K.
  TITLE     GBF1, a guanine nucleotide exchange factor for ADP-ribosylation
            factors, is localized to the cis-Golgi and involved in membrane
            association of the COPI coat
  JOURNAL   Traffic 3 (7), 483-495 (2002)
   PUBMED   12047556
REFERENCE   9  (bases 1 to 6403)
  AUTHORS   Zhao,X., Lasell,T.K. and Melancon,P.
  TITLE     Localization of large ADP-ribosylation factor-guanine nucleotide
            exchange factors to different Golgi compartments: evidence for
            distinct functions in protein traffic
  JOURNAL   Mol Biol Cell 13 (1), 119-133 (2002)
   PUBMED   11809827
REFERENCE   10 (bases 1 to 6403)
  AUTHORS   Claude,A., Zhao,B.P., Kuziemsky,C.E., Dahan,S., Berger,S.J.,
            Yan,J.P., Armold,A.D., Sullivan,E.M. and Melancon,P.
  TITLE     GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide
            exchange factor that displays specificity for ADP-ribosylation
            factor 5
  JOURNAL   J Cell Biol 146 (1), 71-84 (1999)
   PUBMED   10402461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231502.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.7400.1,
                                           SRR26643287.4010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000001.1  254960012-254960260
            250-355             JAXUCZ010000001.1  254971065-254971170
            356-422             JAXUCZ010000001.1  254978690-254978756
            423-554             JAXUCZ010000001.1  255048061-255048192
            555-673             JAXUCZ010000001.1  255053680-255053798
            674-782             JAXUCZ010000001.1  255055570-255055678
            783-843             JAXUCZ010000001.1  255056150-255056210
            844-898             JAXUCZ010000001.1  255057258-255057312
            899-1046            JAXUCZ010000001.1  255060666-255060813
            1047-1270           JAXUCZ010000001.1  255061098-255061321
            1271-1436           JAXUCZ010000001.1  255062208-255062373
            1437-1648           JAXUCZ010000001.1  255063221-255063432
            1649-1747           JAXUCZ010000001.1  255063987-255064085
            1748-1942           JAXUCZ010000001.1  255069136-255069330
            1943-2132           JAXUCZ010000001.1  255069541-255069730
            2133-2273           JAXUCZ010000001.1  255069954-255070094
            2274-2362           JAXUCZ010000001.1  255070390-255070478
            2363-2565           JAXUCZ010000001.1  255071464-255071666
            2566-2689           JAXUCZ010000001.1  255072193-255072316
            2690-2815           JAXUCZ010000001.1  255072589-255072714
            2816-2898           JAXUCZ010000001.1  255072981-255073063
            2899-3135           JAXUCZ010000001.1  255073935-255074171
            3136-3229           JAXUCZ010000001.1  255074448-255074541
            3230-3406           JAXUCZ010000001.1  255074797-255074973
            3407-3471           JAXUCZ010000001.1  255075722-255075786
            3472-3595           JAXUCZ010000001.1  255075873-255075996
            3596-3667           JAXUCZ010000001.1  255076149-255076220
            3668-3762           JAXUCZ010000001.1  255076331-255076425
            3763-3916           JAXUCZ010000001.1  255076801-255076954
            3917-4142           JAXUCZ010000001.1  255081461-255081686
            4143-4303           JAXUCZ010000001.1  255082250-255082410
            4304-4550           JAXUCZ010000001.1  255082513-255082759
            4551-4744           JAXUCZ010000001.1  255082874-255083067
            4745-4895           JAXUCZ010000001.1  255085207-255085357
            4896-5026           JAXUCZ010000001.1  255085463-255085593
            5027-5128           JAXUCZ010000001.1  255085758-255085859
            5129-5242           JAXUCZ010000001.1  255086114-255086227
            5243-5423           JAXUCZ010000001.1  255086358-255086538
            5424-5552           JAXUCZ010000001.1  255086830-255086958
            5553-6403           JAXUCZ010000001.1  255087622-255088472
FEATURES             Location/Qualifiers
     source          1..6403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6403
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
     exon            1..249
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="upstream in-frame stop codon"
     exon            250..355
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5833
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="isoform 6 is encoded by transcript variant 6;
                     golgi-specific brefeldin A-resistance factor 1;
                     Golgi-specific brefeldin A-resistance guanine nucleotide
                     exchange factor 1; golgi-specific brefeldin A resistant
                     guanine nucleotide exchange factor 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform 6"
                     /protein_id="NP_001424994.1"
                     /db_xref="GeneID:309451"
                     /db_xref="RGD:1307160"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     HLKEVLNSGTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSCALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNLKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVMPGSELPTPNGAALSSNLTGGMPFIEAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQATSKEDLTDLEQAGSPREITTTEPGSTEIGVSDQL
                     DPQEGAHVEKAQSASVESIPEVLEECTSPTDHSDSASVHDMDYVNPRGVRFTQSSQKE
                     GTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLL
                     GLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITV
                     ENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPV
                     SGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNTLNQQEKKETARPGFEAVDGSPDTYK
                     SERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTRKPPR
                     FSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWL
                     RENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVI
                     HRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRK
                     NLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGATPEGIF
                     LRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSD
                     VFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNI
                     MEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGP
                     EQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEE
                     TYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLL
                     RLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDD
                     WATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS
                     EVYTDHGRPGKMHRSATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLT
                     VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQD
                     KRGKSHKYDSKGNRFKKKPKEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVSL
                     QLLDLMHTLHTRAASIYSSWAEEQRHLETGGRKIEADSRTLWAHCWCPLLQGIACLCC
                     DARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGM
                     EETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAVPES
                     LKNMLLVMDTAEIFHSADARGGSPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPT
                     EPHSQKPLASTHLTPAAGDPRMPGHPPPPEIPSEVGACDPEKPESTRAASSSSPGSPV
                     ASSPSKQSPAPEGPPPLAQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSPVPLL
                     ATPRPTDPIPTSEVN"
     misc_feature    <1544..>3793
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    <1544..>3793
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="ARF guanine nucleotide exchange factor (ARF-GEF);
                     Provisional; Region: PLN03076"
                     /db_xref="CDD:215560"
     misc_feature    2354..2911
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    2354..2911
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="Sec7 domain; Region: Sec7; pfam01369"
                     /db_xref="CDD:460178"
     misc_feature    <5432..5824
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <5432..5824
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            356..422
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            783..843
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            844..898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1046
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1270
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1436
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1648
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1747
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1942
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2132
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2273
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2362
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2565
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2689
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2815
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2898
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3135
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3229
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3406
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3471
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3595
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3667
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3762
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3916
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4142
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4303
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4550
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4551..4744
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4895
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5026
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5128
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5242
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5423
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5424..5552
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
     exon            5553..6403
                     /gene="Gbf1"
                     /gene_synonym="RGD1307160"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtagccggta ccaccgaccg tcccggccca
       61 cttattccgg cctgcagtga ggtctcaccc taaagttagg gtcgacttcc agacgacagg
      121 ctccttccct tctctcactc gctgccggcg ccgggagagt ggctgggaga cgcctccggg
      181 gccaagctgg acatgagctg cggctgccgg tcctgggact aggccccgcc attttggatc
      241 ctctgacagg tttgtcagga tggtggataa gaatatttac atcattcaag gagaaattaa
      301 cattgttgtt ggtgccatca aacgaaatgc ccgatggagc acccatatac cactggatga
      361 agagcgggat ccccttttgc acagtttcag ccatctaaag gaggtcttaa acagtgggac
      421 agaactctca gagattgagc caaatgtatt ccttcgtcca tttctggaag tcattcgctc
      481 tgaagacacc actggtccta tcaccggcct ggcactcacc tctgtcaaca agttcctgtc
      541 ctgtgcactc atagatccaa ctcatgaggg cacggcagag ggcatggaga acatggcaga
      601 tgctgtcact catgcccgtt ttgtgggcac agatcctgcc agtgatgaag ttgtcctgat
      661 gaaaatcctt caggttctcc ggactttgtt gctaacccca gtgggtaccc acttaacaaa
      721 tgaatctgta tgtgagatta tgcagtcttg cttccggatt tgctttgaaa tgaggctcag
      781 tgagttattg agaaaatccg cagagcacac tctcgtagac atggtgcagc tgctcttcac
      841 aaggttaccg cagtttaaag aagaacccaa gagttacgtg ggaaccaact tgaagaagct
      901 gaaaatgaga gcaggaggca tgagtgactc atccaagtgg aagaaacaga agcgatcccc
      961 tcgacctcca cgtcatacaa ccaaagtcat gccaggttca gagctgccca ccccaaatgg
     1021 agccgcctta tcctctaacc ttactggtgg catgcccttc attgaggcac ccacatccat
     1081 ctcctctgca agttcagaag ctgcctccac agtggtcagt ccctgtacag atagtggcct
     1141 ggaattatcc tcccaggcta cctccaagga ggacctcacc gacctggagc aagctggctc
     1201 cccaagggag atcaccacca cagagcctgg gagcactgag ataggagttt ctgatcagct
     1261 tgaccctcag gaaggggccc atgtagaaaa ggcccagtca gcatcggtgg aatctatccc
     1321 tgaagtgcta gaggagtgca catcccctac tgaccattct gactctgcct ctgtccatga
     1381 catggattat gtcaatcctc ggggcgtgcg ctttacccag tcctcccaga aagaaggcac
     1441 agctttggtt ccttatggtc ttccttgcat ccgtgagctc ttccgcttcc ttatctccct
     1501 cacaaatcca catgaccgcc ataactctga ggttatgatc cacatgggac ttcatttgct
     1561 gacagtagct cttgagtcag cccctgtggc ccagtgccag accctcttgg gtctcatcaa
     1621 ggatgagatg tgccgacact tattccagct actcagcgta gagcggctga acctttacgc
     1681 tgcttcccta cgagtgtgct ttttgctctt tgagagcatg cgggaacacc tcaagttcca
     1741 gttggagatg tacatcaaaa agctcatgga gattatcact gttgaaaacc ccaagatgcc
     1801 ttatgagatg aaggagatgg cgctggaggc cattgtgcag ctctggcgca tccccagctt
     1861 cgtcacggag ctctacatca actatgactg tgactactac tgctccaacc tcttcgaaga
     1921 cctcactaag ctgctgtcca agaatgcctt tcctgtgtct ggccagcttt atacaacaca
     1981 cctgctgtct cttgatgccc tattgacagt tattgacagc actgaggctc attgtcaggc
     2041 caaagtcctc aacaccctca accagcaaga gaagaaagag acagccagac ctggctttga
     2101 ggcagtggat ggcagcccag acacttacaa gtctgagaga gcagccagtg atgggaaagc
     2161 cacaggagtg ccctcagatg ctccaggcct tcatttttca agtggagggt ggttgtcaac
     2221 agaacatgga aagccagggt gcagtgatct ggaggaagct ggtgactctg gggttgacaa
     2281 aaagaccacc aggaagccac ctcgattttc ctgtcttctg ccagatccac gggaactaat
     2341 tgaaattaaa aacaaaaaaa agctgctgat cactggtaca gagcagttca accaaaaacc
     2401 aaagaagggg atccagtttc tgcaggagaa aggcctcctc accatcccaa tggataacac
     2461 agaggtagcc cagtggctcc gagaaaaccc tcggctagac aaaaaaatga ttggagagtt
     2521 tgtgagtgac cgcaaaaaca tggacctgtt ggagagtttt gtgagcacct tcagcttcca
     2581 gggtctgagg cttgatgagg ctctccgcct ctacctagaa gccttccgtc tgcctgggga
     2641 agcgcctgtt attcacaggc tgctggaggt gttcactgag cactggagga gttgtaatgg
     2701 ctccccattt gctaatagcg atgcctgctt tgccctggcc tatgctgtta tcatgcttaa
     2761 cactgaccaa cataaccaca atgttcgcaa gcaaaatgca cccatgaccc tggaggagtt
     2821 ccgcaaaaac ctgaaaggtg tgaatggagg caaggacttt gagcaagaca tcctggaaga
     2881 catgtaccat gccatcaaga atgaggaaat tgtgatgcct gaggaacaaa caggtctggt
     2941 tcgtgagaat tatgtgtgga gtgtgctgct tcatcgaggt gctacccctg agggcatctt
     3001 ccttcgtgta ccccctggca gctatgatct tgacctcttc actatgacct ggggccccac
     3061 tattgctgct ctctcttatg tgttcgataa aagcctcgag gagaccatca tccagaaagc
     3121 catctcaggc ttcaggaagt gtgccatgat ctccgcccac tatggcctca gcgatgtgtt
     3181 tgacaatctc atcatctctc tgtgcaaatt cacagctcta agtagtgagt ctattgagaa
     3241 cctgcccagt gtattcggaa gcaaccctaa agcccacatt gcagccaaga cagtattcca
     3301 tttggcccat cgtcatggtg acatccttcg ggagggctgg aagaatatca tggaggccat
     3361 gctgcagctc ttccgagccc aacttttacc gaaggctatg gtagaggtag aagattttgt
     3421 ggatcccaat ggtaagatct ctctacagcg ggaggagaca ccatcaaacc gaggagagtc
     3481 aacagtcctt agttttgtaa gctggctgac actgagtggt cctgagcagt ccagtgtccg
     3541 gggcccatcg acagagaacc aagaggccaa gcgagtagcc ttggactgca tcaagcaatg
     3601 tgacccagaa aagatgatca cagaaagcaa gttcctccag ctggaatctc tgcaggagct
     3661 catgaaggct ctggtctcgg tgacaccaga tgaagagaca tatgatgaag aagatgctgc
     3721 tttctgtctg gagatgctgc taaggattgt gttagaaaac agggaccgtg tgggctgtgt
     3781 atggcagact gttcgagatc atctatacca cctgtgtgtt caggcacaag atttctgctt
     3841 ccttgtggag cgagcagtgg tagggctgct acgcctagcc attcggctac tccgaagaga
     3901 agagattagt ggccaggtcc tgctctctct gcgcatcttg ttactgatga agcccagcgt
     3961 gctgtccaga gtcagccacc aggtcgctta tgggctgcat gaactcctca agaccaatgc
     4021 tgccaacatc cactcgggtg atgactgggc cactctcttc acattgctgg agtgcattgg
     4081 ctcaggcgtg aagcctccag atgctctaca agccacagcc agggctgatg ctcctgatgc
     4141 tggagcacaa tccgacagtg agctcccatc ctaccatcaa aatgatgtca gcctagaccg
     4201 agggtacact tccgactcag aagtctacac tgaccatggc aggcctggca agatgcaccg
     4261 atcagccaca gacgctgaca tggccaacag tggttggtta gtggtgggga aggatgacat
     4321 tgataactcc aaaccagcag caggactcag caggccaggc ccttcgccct tggtcaatca
     4381 gtacagcctt acagtgggcc tggacctggg accacatgac actaagtcct tgcttaagtg
     4441 tgtggagtct ctgtccttca ttgttcgtga tgctgctcac atcacccctg acaactttga
     4501 actctgcgtc aagaccctcc gcatctttgt agaagccagt ctgaatggtg ggtgcaagtc
     4561 ccaggataaa cgtggcaaga gtcataaata tgacagcaaa gggaaccggt tcaagaaaaa
     4621 gcccaaggag ggctcgatgc ttcggcggcc ccgggcatcc agccagcatg ccactcgggc
     4681 tggacacagt gatgaagagg aggacgaagg cgtgcctgcc agctaccata cggtgtcttt
     4741 acagttgcta gacctgatgc acaccctgca cacacgggca gcctctatct acagttcatg
     4801 ggcagaggag caacgccacc tggagacagg tggccggaag attgaagctg actcacgtac
     4861 cctctgggcc cactgctggt gccctttatt acaaggtatc gcttgcttat gctgtgacgc
     4921 ccggcgccag gtgcggatgc aggccctgac atatctccag cgagcccttc tggtacatga
     4981 cctgcaaaag ctagatgccc tggaatggga gtcctgtttt aacaaggtgc tgtttccgct
     5041 actgaccaag cttttagaaa atatcagccc tgcggatgtg ggcgggatgg aggagacccg
     5101 gatgcgggct tccacactgc tctcaaaggt cttcctgcag cacctgtccc cactgctgtc
     5161 cctgtccacc tttgctgccc tgtggctcac catcctggac ttcatggaca agtacatgca
     5221 cgcaggttcc agtgacttgc tgtcagaagc tgtccctgag tctctgaaga acatgctcct
     5281 tgtgatggac acagcagaga ttttccacag tgcagatgca aggggaggca gcccctctgc
     5341 tctctgggag atcacctggg agcgcatcga ttgcttctta ccacacctac gtgatgaact
     5401 cttcaagcag actgtcatcc aggaccccat gcccacagag cctcacagtc aaaaacctct
     5461 ggcttctact cacctgacgc ctgctgctgg tgaccccagg atgcctggcc atccacctcc
     5521 tccagagata ccctcagaag tgggagcttg tgacccggag aagcccgaga gcaccagagc
     5581 tgccagcagc agctcccctg gatcgccggt ggcctctagc cccagcaaac agagtcctgc
     5641 cccagaggga cctcccccac tggcccagcc cccactaatc ctacagccct tgacctcccc
     5701 actgcaggtg ggggtaccac ccatgacttt gcccatcatc ctcaaccctg cactcattga
     5761 ggccacctct ccagtgcctc tcttagccac gccacgccct acagacccca tccccacctc
     5821 tgaggtcaac taaggcagcc actcagaggt caggaccatt ccttcctatc aggcattcaa
     5881 ggccctgctt ccagtcccag gggccacaga aatcttcagg cccaaagcaa gctgctgtta
     5941 ccactgcttg acagggggat gacgatgttt atagtccctg ctgggatcca ctccaggctg
     6001 cgaggttctt cctctgccgt tcagtcctga acttccaagc tgagagtgga tgcaggctga
     6061 acctgtagcc tctgcctctg gcctggcagc cctggggagg catagagcca accctgctgt
     6121 gccaaccctg cagtgcctgc catgtgcccc ctgccaggtt gggcattagg agccaagccc
     6181 gacctctctg cactttgttc ctctccctat ccagtccatc agtcctgggc cactgcctcc
     6241 agttcttctt ccttcattaa atagttggtc agtttggagt cgcttggcac catggagggt
     6301 ggacaggtag gactcgatgg ggggtctgcc cacaggagca tgtacatatg gaaaaataac
     6361 attggacttt ttatgatata ataaatgtct tagtaccaac aca
//
LOCUS       NM_001438113            2902 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus LSM14A mRNA processing body assembly factor
            (Lsm14a), transcript variant 1, mRNA.
ACCESSION   NM_001438113 XM_006228856
VERSION     NM_001438113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Tanaka,K.J., Ogawa,K., Takagi,M., Imamoto,N., Matsumoto,K. and
            Tsujimoto,M.
  TITLE     RAP55, a cytoplasmic mRNP component, represses translation in
            Xenopus oocytes
  JOURNAL   J Biol Chem 281 (52), 40096-40106 (2006)
   PUBMED   17074753
  REMARK    Erratum:[J Biol Chem. 2014 Jul 25;289(30):20490]
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Yang,W.H., Yu,J.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     RNA-associated protein 55 (RAP55) localizes to mRNA processing
            bodies and stress granules
  JOURNAL   RNA 12 (4), 547-554 (2006)
   PUBMED   16484376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006228856.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1835.1,
                                           SRR26643287.986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000001.1  96146222-96146483   c
            263-426             JAXUCZ010000001.1  96131509-96131672   c
            427-556             JAXUCZ010000001.1  96127661-96127790   c
            557-679             JAXUCZ010000001.1  96122104-96122226   c
            680-856             JAXUCZ010000001.1  96116217-96116393   c
            857-922             JAXUCZ010000001.1  96115848-96115913   c
            923-1105            JAXUCZ010000001.1  96111458-96111640   c
            1106-1277           JAXUCZ010000001.1  96111181-96111352   c
            1278-1509           JAXUCZ010000001.1  96109086-96109317   c
            1510-2902           JAXUCZ010000001.1  96101906-96103298   c
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2902
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
     exon            1..262
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="upstream in-frame stop codon"
     CDS             142..1533
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="isoform 1 is encoded by transcript variant 1; LSM14
                     homolog A; protein LSM14 homolog A; LSM14A, SCD6 homolog
                     A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 1"
                     /protein_id="NP_001425042.1"
                     /db_xref="GeneID:361554"
                     /db_xref="RGD:1305695"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGSSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDSKRQVVPGVPSAPRRGRGGHR
                     GGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNG
                     EDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLN
                     AETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREF
                     ADFEYRKDNKVAA"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    151..372
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Like-Sm protein 14, N-terminal domain; Region:
                     LSm14_N; cd01736"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(175..195,199..237,244..258)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm1 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    order(229..231,235..237,343..345)
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    331..366
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="Sm2 motif; other site"
                     /db_xref="CDD:212483"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     misc_feature    1009..1341
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /note="FDF domain; Region: FDF; pfam09532"
                     /db_xref="CDD:430668"
     exon            263..426
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            427..556
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            557..679
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            680..856
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            857..922
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1105
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1277
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1509
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2902
                     /gene="Lsm14a"
                     /gene_synonym="RGD1305695"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggagcc ggcgcagccg ccatgttggt tctgaagaag ctgctgtgag gcgccgacgg
       61 agcgagcggg cgggcgtgcg gagcggcggg cgcagcgcgg gatctgcctg agtgcgagcg
      121 gcgggcgacg gcggcggcgc catgagcggg ggcacccctt acatcggcag caagatcagc
      181 ctcatctcca aggcggagat ccgctacgag ggcatcctct acaccatcga caccgagaac
      241 tccactgtag ccctcgccaa agttcgatcc ttcggtacag aagacagacc aacagatcgt
      301 ccaataccgc ctcgagatga agtctttgaa tatattatat tccggggaag tgacattaaa
      361 gacctcactg tttgtgagcc gcccaaacca cagtgttctt tgcctcagga cccagctatt
      421 gttcagtctt cactaggttc gtcatcttcc tcgttccagt cagtgggttc ctatggacct
      481 tttggcagga tgccagcata cagtcagttc agtccaagta cattagttgg gcaacagttt
      541 ggtgctgttg gtgttgctgg gagctccttg acatcctttg gaacagaagc atcaaatagt
      601 ggtaccttat cccagagcaa tgcagttggt tcggccttca cgcaggatac aagatctgta
      661 aaaccacagc tggcccaagg tcgatcaagc cctcagttag accctttgag aaaaagtcca
      721 accatggaac aagcagtgca gaccgcctcg gcccacttac ctgctccagc acctgttggg
      781 agaaggagcc ctgtacccgc caggcctttg ccacctacca gccagaaagc aatagacaac
      841 caagagcaca ggcgagctga agttcacaaa gtcccaaggc cagaaaatga gcaactcaga
      901 aatgacagca agaggcaagt agttcctgga gttccttctg ctccaagaag aggacgtggg
      961 ggtcatcgag gtggcagggg aagatttggt attcgtcgag atggtccaat gaaatttgag
     1021 aaagactttg actttgaaag tgcaaatgca caatttaaca aggaggaaat cgacagagag
     1081 tttcataata aacttaaatt aaaagaagat aaacttgaga aacaagagaa acctgtaaac
     1141 ggtgaagaca aaggagactc gggagttgat acccagaaca gcgaggggaa tgctgatgag
     1201 gaagatcccc ttgggcccaa ctgctactac gacaaaacca aatccttctt cgacaacatc
     1261 tcttgtgatg ataatagaga aaggagacca acttgggctg aagaaagaag gttaaatgct
     1321 gaaacttttg gaatcccact tcgtccaaat cgtggccgtg ggggttaccg aggcagagga
     1381 ggccttggct tccgtggtgg cagaggacgt ggtagtggcc gaggaggaac cttcactgcc
     1441 cctcgagggt ttcgtgctgg attcagaggc gctcgtgggg gtagggagtt tgcagatttt
     1501 gaatatagga aagacaacaa agttgctgca tagtctacaa acaagtctct gaacataggt
     1561 gactcctagc tcttcatggt cctggaaagt ggttcggtct ttgtgaagaa tgaagaagtg
     1621 aagttgctgt ctgtctgtca ccagcactgg gttttgtctg ttttctgctt cacgtcaaag
     1681 ctatactgca gttgctttgg ggcaggaagg ctcgtcttaa aacacaagca taagtgtgtg
     1741 tggagtagca ggttatgatt ccttgcttag agttgaacta aagccagcta aatggaattg
     1801 ctaagtgttt tttcttcaat gaaaggattt ttcttatcac taattaattg tattcggcaa
     1861 ttactttgag ttgcctgcag ataggccgtg atactgtgtt ttgagccaca gaaagttttg
     1921 tgtgtgtgcg cgcgcgcgcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta cgtgtgtgtc
     1981 ccataatatg aggtagctta tttcgacact taattagggt gctggatggt agagaatttt
     2041 gtcagtcaac tatgtacaca caggtaaata ctgtttctta ggcaaaggta acttttttat
     2101 atagttgtaa aattccatta tattccattg ccaaagaaac attaagaact ttgtatagct
     2161 gtataaaaag caactaattt tttaaagaat aaacgtttta aagtcagcaa acatacgtgt
     2221 ccttgcagaa gtcagtgtgc tgaggagcag ggatatgggt gggtcttttt ccccttgctt
     2281 tccaggctta aggtttttta tttcctttgt aatgtttgga acacaaatga agatttgata
     2341 actttattcc attatctaaa aagcataaat tattcatgca tagtgtatgg acttcgtttt
     2401 gtagcaaatc acaggatttg ttcaaataac agatatttta agtgtgtgaa tgtaaataat
     2461 catagatgag aatgtacctt gctgtatttt caaataagta accttctcct ttttaagaca
     2521 ttaagactcg ttgatctatc agttgacccg ctcctcctgc tatgcctgga attctgttgt
     2581 ggtaatgctg actcctgttt tccatcaaaa agatggagtt ttcagaatca tctggcacct
     2641 gtaaaacatc actaacatag tgtgtaggcc tgcggcctac cgatgactct gtacacgttt
     2701 gttgctaact gtaaattact aataaatctt ttttgatatt taagctatag tggaaaaaga
     2761 tctggccact ttgtgttttt aataaaggcc atggaataaa gggatccaaa gatttcaata
     2821 tttttaacta tattggcttt tgttaacttt ctcaataaaa cattgagtag tgatagacgt
     2881 gtgggaaact gcactgtagg ag
//
LOCUS       NM_001438085            2229 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 1, mRNA.
ACCESSION   NM_001438085 XM_039081733
VERSION     NM_001438085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Samuel,S., Zhang,K., Tang,Y.D., Gerdes,A.M. and
            Carrillo-Sepulveda,M.A.
  TITLE     Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling
            in Vascular Smooth Muscle Cells
  JOURNAL   Cell Physiol Biochem 41 (5), 1894-1904 (2017)
   PUBMED   28376489
  REMARK    GeneRIF: findings have uncovered a PKG/VASP signaling pathway in
            Vascular Smooth Muscle Cells as a key molecular mechanism
            underlying T3-induced vascular relaxation.
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Basu,S., Kustanovich,I. and Lamprecht,R.
  TITLE     Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral
            Amygdala
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   27957528
  REMARK    GeneRIF: Study showed that Arp2/3 and VASP, but not formins, are
            needed in lateral amygdala for long-term, but not short-term, fear
            memory formation. Results suggest a mechanism whereby actin
            cytoskeleton remodeling leads to changes in neuronal morphogenesis
            needed for memory consolidation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Li,H., Liu,J., Wang,W., Zhang,Z., Li,D., Lin,K., Chen,Z. and Lin,W.
  TITLE     Matrix Metalloproteinase 9 and Vasodilator-Stimulated
            Phosphoprotein Related to Acute Kidney Injury in Severe Acute
            Pancreatitis Rats
  JOURNAL   Dig Dis Sci 60 (12), 3647-3655 (2015)
   PUBMED   26264698
  REMARK    GeneRIF: In the presence of acute kidney injury in severe, acute
            pancreatitis, the renal expression of MMP-9 and VASP is related to
            damage of endothelial cells in capillaries, which reached a maximum
            at 24 h and declined afterwards.
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Riquelme,D.N., Meyer,A.S., Barzik,M., Keating,A. and Gertler,F.B.
  TITLE     Selectivity in subunit composition of Ena/VASP tetramers
  JOURNAL   Biosci Rep 35 (5), e00246 (2015)
   PUBMED   26221026
  REMARK    GeneRIF: Co-expression of VASP increased the ability of Mena and
            EVL to form mixed oligomers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Zhao,H., Guan,Q., Smith,C.J. and Quilley,J.
  TITLE     Increased phosphodiesterase 3A/4B expression after angioplasty and
            the effect on VASP phosphorylation
  JOURNAL   Eur J Pharmacol 590 (1-3), 29-35 (2008)
   PUBMED   18571642
  REMARK    GeneRIF: Increased phosphodiesterase 3A/4B expression after
            angioplasty and the effect on VASP phosphorylation.
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Ferron,F., Rebowski,G., Lee,S.H. and Dominguez,R.
  TITLE     Structural basis for the recruitment of profilin-actin complexes
            during filament elongation by Ena/VASP
  JOURNAL   EMBO J 26 (21), 4597-4606 (2007)
   PUBMED   17914456
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Menzies,A.S., Aszodi,A., Williams,S.E., Pfeifer,A., Wehman,A.M.,
            Goh,K.L., Mason,C.A., Fassler,R. and Gertler,F.B.
  TITLE     Mena and vasodilator-stimulated phosphoprotein are required for
            multiple actin-dependent processes that shape the vertebrate
            nervous system
  JOURNAL   J Neurosci 24 (37), 8029-8038 (2004)
   PUBMED   15371503
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_039081733.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.1768.1,
                                           SRR26643297.975.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000001.1  88052773-88053076   c
            305-479             JAXUCZ010000001.1  88045950-88046124   c
            480-645             JAXUCZ010000001.1  88045709-88045874   c
            646-730             JAXUCZ010000001.1  88043417-88043501   c
            731-768             JAXUCZ010000001.1  88042666-88042703   c
            769-1010            JAXUCZ010000001.1  88042312-88042553   c
            1011-1111           JAXUCZ010000001.1  88042068-88042168   c
            1112-1163           JAXUCZ010000001.1  88040749-88040800   c
            1164-1200           JAXUCZ010000001.1  88040554-88040590   c
            1201-1246           JAXUCZ010000001.1  88040283-88040328   c
            1247-1337           JAXUCZ010000001.1  88040092-88040182   c
            1338-1395           JAXUCZ010000001.1  88038970-88039027   c
            1396-2229           JAXUCZ010000001.1  88038026-88038859   c
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2229
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
     exon            1..304
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Vasp"
                     /note="upstream in-frame stop codon"
     CDS             300..1433
                     /gene="Vasp"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="vasodilator-stimulated phosphoprotein isoform 1"
                     /protein_id="NP_001425014.1"
                     /db_xref="GeneID:361517"
                     /db_xref="RGD:1311542"
                     /translation="MSNETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPT
                     ANSFRVVGRKLQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAAQ
                     FAIGMANALEALEGGGPPPAPAPPAWSTQNGPSPEELEQQKRQPEHLERRVSNAGGPP
                     APPAGGPPPPPGPPPPPGPPPPPGLPPSGVSGAGHGTGVAPPPAPPLPTAQGPSSGGS
                     GAPGLAAAIAGAKLRKVSKQEEASGGPLAPKAENSRGTGGGLMEEMNAMLARRRKATQ
                     VGEKPPKDESASQEESEARIPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSVPS
                     SSDDSDLERVKQELVEEVRKELQKMKEEIIEVFVQELRKRGSP"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    315..641
                     /gene="Vasp"
                     /note="Enabled/VASP family EVH1 domain; Region:
                     EVH1_Ena_VASP-like; cd01207"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    order(348..350,369..371,513..515,519..521,537..539,
                     543..545,549..551)
                     /gene="Vasp"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269918"
     misc_feature    945..1025
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    945..1025
                     /gene="Vasp"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; Region:
                     WH2_hVASP-like; cd22185"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    order(966..971,975..980,987..989,993..1007)
                     /gene="Vasp"
                     /note="actin-binding motif [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    993..1004
                     /gene="Vasp"
                     /note="actin-binding sequence [structural motif]; Region:
                     actin-binding sequence"
                     /db_xref="CDD:409225"
     misc_feature    1320..1418
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     misc_feature    1320..1418
                     /gene="Vasp"
                     /note="VASP tetramerization domain; Region: VASP_tetra;
                     pfam08776"
                     /db_xref="CDD:462599"
     exon            305..479
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            646..730
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            731..768
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1010
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1111
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1163
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1200
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1246
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1337
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1395
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2229
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtagtaa gagtaaccgc gtaggtgctg ccggctgagg gggtgcgccg gcgaggttcg
       61 gacgctgcac cccgctttcc atcgcagggg atcccagcac atcagagcac cggagggagg
      121 aggcgcctga gcacccgccc gggcccggtc cacgttctcc ccaggaagct ggactctatg
      181 gggcgggacc ccgagagaga ctgagcagaa cctggagcca gccccgcacc cctgcacttc
      241 caatcagggg cgccccggga gcactccccg tgggcgcgcc gcctgccctc tgcgcagcca
      301 tgagcaacga gacggtcatt tgttccagcc gggctactgt gatgctttac gatgacagca
      361 acaaacgatg gcttcctgct ggcaccggtc cccaggcctt tagccgcgtc cagatctacc
      421 acaaccccac tgctaactct ttccgagttg ttggccgcaa gctgcagcct gaccagcagg
      481 tggttatcaa ctgtgccatc attcgaggtg tcaagtacaa tcaggccact cccatattcc
      541 accagtggcg tgatgcccgc caggtctggg gcctcaactt cggcagcaag gaggacgctg
      601 cgcagtttgc gatcggcatg gccaatgccc tggaggcctt ggaaggaggt gggcctcccc
      661 ctgccccagc accccctgcc tggtctaccc agaatggccc ctccccagag gagctggaac
      721 aacagaaaag gcagcctgaa catttggagc gccgggtctc caatgcagga ggcccacctg
      781 ctcccccagc tgggggccca cctccacctc caggacctcc ccctcctccg ggtccccccc
      841 cacccccagg tctgcccccc tcaggggtat ctggggcagg tcatggaaca ggtgtagccc
      901 caccccctgc acccccactc cctacagcac agggccccag tagtgggggt tccggggccc
      961 caggcctggc cgctgccatt gctggagcca aactcaggaa agtgagcaag caggaggagg
     1021 cctctggggg gcccctggcc cccaaagctg agaatagtcg aggcactggt ggggggctta
     1081 tggaagagat gaacgccatg ctggcccgga gaaggaaagc cacacaggtt ggggagaagc
     1141 cccccaaaga cgagtcagcc agtcaggagg agtcagaggc ccgaatccct gcccaaagtg
     1201 aacctgtgcg aagaccctgg gagaagaaca gcacaacctt gccaaggatg aagtcatcct
     1261 cttctgtgac tacctccgag gcccacccct ctgtgcccag ctccagtgat gactccgact
     1321 tggagagggt gaagcaggag cttgtggaag aggtgcggaa ggagctacag aaaatgaaag
     1381 aggaaataat cgaagtcttt gtccaggagc tgaggaagcg gggttctcct tgactacagg
     1441 gacccagaag acccatttct tctttttgta cttcctgcct ggcacctgct ttccctgcct
     1501 caacttgacc aagagttaca caagaatgcg ttctccccta ccagctccca cttggaagat
     1561 tccacagggg tgtggcttcc tggtgccgtg gtcacaccca cgctggctgc tgattggata
     1621 aggaggtccc acccctttgt tccctttggt ccttcccctt caccatcccc ttggagctgg
     1681 ttcctctgct ggggatgtaa gagtaacccc acagtaaggg aaggaaggag gggatctcac
     1741 cttctcttgt tctggattca ctttaacgct ttaatgcctt ggaatttttt tttttaagaa
     1801 aaagtatata tatatatttg ggttttgtgg ggggaaggga aattttttgt tctctttggt
     1861 tttgataaaa tggggtgtgg gagtttttaa atgctatacc ccaagctttg tcccatcaga
     1921 ggcagctatg taagaggagg ggtatcccac caagtagggg gcatttcccc cacccctggg
     1981 atacctcccc atttgccttg gctcctctct cttttctata aggaattaag attctttaac
     2041 ttttttggaa cctcagtttt gtggtttttt ttatttgggt taggatttca gggtccagac
     2101 catttttgcc ctccaggaag acgaagtgag ggggaggaga agaggaaaaa taggtcctcc
     2161 gacttctaca ccatagcttc ttggacacgg gccctcgctg aataaatctg cagtttttat
     2221 aaatgcaaa
//
LOCUS       NM_001438032            6867 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2),
            transcript variant 1, mRNA.
ACCESSION   NM_001438032 XM_006231209
VERSION     NM_001438032.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6867)
  AUTHORS   Wang,T., Chen,S., Wang,X., Huang,Y., Qiu,J., Fei,Y., Chaulagain,A.,
            Chen,Y., Wang,Y., Lin,L., Yan,B., Wang,Y., Wang,W., Zhao,W. and
            Zhong,Z.
  TITLE     Aberrant PD-1 ligand expression contributes to the myocardial
            inflammatory injury caused by Coxsackievirus B infection
  JOURNAL   Antiviral Res 166, 1-10 (2019)
   PUBMED   30904424
REFERENCE   2  (bases 1 to 6867)
  AUTHORS   He,H., Zhou,Y., Zhou,Y., Zhuang,J., He,X., Wang,S. and Lin,W.
  TITLE     Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation
            through Upregulation of Programmed Cell Death Protein 1 in a Rat
            Spinal Cord Injury Model
  JOURNAL   J Neurotrauma 35 (21), 2591-2603 (2018)
   PUBMED   29665726
REFERENCE   3  (bases 1 to 6867)
  AUTHORS   Wilson,J.K., Zhao,Y., Singer,M., Spencer,J. and Shankar-Hari,M.
  TITLE     Lymphocyte subset expression and serum concentrations of PD-1/PD-L1
            in sepsis - pilot study
  JOURNAL   Crit Care 22 (1), 95 (2018)
   PUBMED   29661225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6867)
  AUTHORS   Singh,A., Mohan,A., Dey,A.B. and Mitra,D.K.
  TITLE     Inhibiting the programmed death 1 pathway rescues Mycobacterium
            tuberculosis-specific interferon gamma-producing T cells from
            apoptosis in patients with pulmonary tuberculosis
  JOURNAL   J Infect Dis 208 (4), 603-615 (2013)
   PUBMED   23661793
REFERENCE   5  (bases 1 to 6867)
  AUTHORS   Cao,J., Liu,F.X. and Yu,M.X.
  TITLE     Expression of programmed death 1 and its ligands in the liver of
            autoimmune hepatitis C57BL/6 mice
  JOURNAL   Chin Med J (Engl) 122 (16), 1941-1946 (2009)
   PUBMED   19781375
REFERENCE   6  (bases 1 to 6867)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
REFERENCE   7  (bases 1 to 6867)
  AUTHORS   Liang,S.C., Greenwald,R.J., Latchman,Y.E., Rosas,L., Satoskar,A.,
            Freeman,G.J. and Sharpe,A.H.
  TITLE     PD-L1 and PD-L2 have distinct roles in regulating host immunity to
            cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 36 (1), 58-64 (2006)
   PUBMED   16358363
REFERENCE   8  (bases 1 to 6867)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   9  (bases 1 to 6867)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 6867)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231209.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.4214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000001.1  236591183-236591523
            342-647             JAXUCZ010000001.1  236604073-236604378
            648-917             JAXUCZ010000001.1  236617238-236617507
            918-1053            JAXUCZ010000001.1  236620844-236620979
            1054-6867           JAXUCZ010000001.1  236636875-236642688
FEATURES             Location/Qualifiers
     source          1..6867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..6867
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
     exon            1..341
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    209..211
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="upstream in-frame stop codon"
     CDS             287..1093
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PD-1 ligand 2; PDCD1 ligand 2; programmed death
                     ligand 2"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 isoform 1
                     precursor"
                     /protein_id="NP_001424961.1"
                     /db_xref="GeneID:309304"
                     /db_xref="RGD:1306403"
                     /translation="MLLLLLILNLSSQLHHIAALFTVTAPKEVYTVDFGSSVSLECDF
                     DRRECTELEGIRASLQKVENDTSSQSQRATLLEELLPLGKASFHIPSVQVRDSGQYRC
                     LVICGAAWDYKYLTVKVKASYVRIDTGILEVPGTGEVQLICQARGYPLAEVSWQNVSV
                     PANTSHIRTPEGLYQVTSVLRLKPQPNRNFSCMFWNAHMKELTSAIIDPLSWMEPKVP
                     RTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKRSEPAVLGVGKIQ"
     sig_peptide     287..343
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    344..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin Variable (IgV) domain of Programmed
                     death ligand 2 (PD-L2); Region: IgV_PD-L2; cd20983"
                     /db_xref="CDD:409575"
     misc_feature    344..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin Variable (IgV) domain of Programmed
                     death ligand 2 (PD-L2); Region: IgV_PD-L2; cd20983"
                     /db_xref="CDD:409575"
     misc_feature    order(344..352,359..361,368..370,452..454,464..466,
                     485..487,587..589,593..595,599..601,605..616,620..628)
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Receptor-Ligand Binding Site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409575"
     misc_feature    order(344..352,359..361,368..370,452..454,464..466,
                     485..487,587..589,593..595,599..601,605..616,620..628)
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Receptor-Ligand Binding Site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409575"
     misc_feature    344..415
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409575"
     misc_feature    344..415
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409575"
     misc_feature    350..361
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409575"
     misc_feature    350..361
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409575"
     misc_feature    368..382
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409575"
     misc_feature    368..382
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409575"
     misc_feature    389..415
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409575"
     misc_feature    389..415
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409575"
     misc_feature    416..451
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409575"
     misc_feature    416..451
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409575"
     misc_feature    449..469
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409575"
     misc_feature    449..469
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409575"
     misc_feature    452..475
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409575"
     misc_feature    452..475
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409575"
     misc_feature    476..499
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409575"
     misc_feature    476..499
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409575"
     misc_feature    482..493
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409575"
     misc_feature    482..493
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409575"
     misc_feature    500..598
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409575"
     misc_feature    500..598
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409575"
     misc_feature    500..514
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409575"
     misc_feature    500..514
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409575"
     misc_feature    536..559
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409575"
     misc_feature    536..559
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409575"
     misc_feature    569..601
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409575"
     misc_feature    569..601
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409575"
     misc_feature    599..610
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409575"
     misc_feature    599..610
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="CDR3 [structural motif]; Region: CDR3"
                     /db_xref="CDD:409575"
     misc_feature    608..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409575"
     misc_feature    608..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="FR4 [structural motif]; Region: FR4"
                     /db_xref="CDD:409575"
     misc_feature    614..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409575"
     misc_feature    614..643
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409575"
     misc_feature    665..910
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    665..910
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    701..715
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    701..715
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    740..754
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    740..754
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    818..832
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    818..832
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    851..868
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    851..868
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    896..907
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    896..907
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            342..647
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..917
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1053
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..6867
                     /gene="Pdcd1lg2"
                     /gene_synonym="PD-L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgttcatc ctgctctcca gaaaaggccc tgcgagaagc aaaaagagca gctcatttga
       61 attcagaaag agtgccttct tcctccttgc tgtgcataag ctcttctcca gaaaaggaac
      121 ccacgggctc tcttcttgtc tctgctactc cattgtcacc tgcatctccc acaagatttg
      181 attctgagtc attaccatgc tcttgggatg agttaaactg gcggagactg agaaagtgca
      241 cggagcccgg agactctcaa ttgtctgttt cagattgata cagaccatgc tgctcctgct
      301 gctgatactg aacctgagct cgcaacttca tcacatagca gctttattca cggtgacagc
      361 ccctaaggag gtgtacaccg tagacttcgg cagcagtgtg agcctggagt gtgattttga
      421 ccgcagagaa tgcaccgagc tagaaggaat aagagccagt ttgcagaagg tagaaaacga
      481 tacttcttca caaagtcaaa gagccaccct gctggaagag ctgcttcccc tggggaaggc
      541 ttcgttccac atccccagtg tccaagtgag agattcaggg cagtaccgtt gtctggtcat
      601 ctgcggggcc gcctgggact acaagtacct gacggtgaaa gtcaaagctt cttacgtgag
      661 gatagacact gggatcctag aggttccagg gacaggggag gtgcagctca tctgccaggc
      721 tagaggttac cccctagcag aagtgtcctg gcaaaatgtc agtgttcctg ccaacaccag
      781 ccacatcagg acccctgaag gcctctacca ggtcaccagt gttctgcgcc tgaagcctca
      841 gcctaacaga aacttcagct gcatgttctg gaatgctcac atgaaggagc ttacttcagc
      901 catcattgac cctctgagtt ggatggaacc caaagtcccc agaacacggt cacttcatgc
      961 tttcatcccg gcctgcactg tcgctctcat cttcctagcc acagtgatag cccagagaaa
     1021 gaggctctgg ggaaagctgt attctagaaa aagatctgag cctgcggtct tgggagttgg
     1081 gaagatccaa taggaaatcc tcaagaggct tctggactca aagtgagaat ctagcagagc
     1141 cgccatttgc acttttcgaa tgctgatcag gagcttgcag gactgccaag actgccttcc
     1201 cttcctctca agactctctc tgaacaaaaa caaccacaat ggcaccctag agtcctccct
     1261 cccccccccc ctggggatcc tggaccccag tgaagccctt cctggtttcc agggtgaaaa
     1321 caaaaggaat tgttcttcct cctccccctg cgttccacgg ggagacaagg aaattcccag
     1381 ttactaaaat agattgtgtt gataatagag ttttttaata tctgtcattt cctctgggga
     1441 tttggaagtt tcagaaaggg tttttagtaa acaaagtcat aactgatgtg tttcactgca
     1501 tcctagaatc ctggcagcct ctgaagttct gattatcagg aagcatttga gtacacaact
     1561 gtggaatttg tttctacttt tcttttttta aagctgagtc acacaaggca tttgttgtaa
     1621 cctgtgatgt cactgtttat tgatctcttc tctttcaact acatttttta agacgaaacg
     1681 gtgtagggtt ttgttgtttt gttggtggtg gtagtgtttc tcagtggtat cactttaaga
     1741 aaaaaaaaat catcatgcca gttctttctt tagacggttc agatgaggag ctgtaatcac
     1801 cagtcccccg agctaagcct tcttccctag ccttccgtgt gattttacgt tgaacgtttg
     1861 tgttgctctg tttctataac tgtaatgtgg tgatgtcatt gtcggggcat ttgatgatga
     1921 gcattctgga agtccttttg taagagaaaa accctctgag ccctacgttc agccccactc
     1981 acagagacac agagacagga tcaatgcaat aagcaagagg tttcatgatc cagtgcactg
     2041 gggtggccct gtactcaggg cagaggcgac ctcaaagaac aaaggcccac gccctttata
     2101 ctgtttttca gggtataggc tttaggttac agcatgagtt gattatttct cattggtggg
     2161 ccctattacc ttttgaattc attggtggct gcctatcgtc ctttgaagtc attggaggcc
     2221 cttggtgggg aagtatattt ggcatgcagt gggggtgatg aaggactcct gctaagggca
     2281 gctacctcat ttcctggaac agggtgttat cctaaattcc acctggtgtt tggctaaggc
     2341 agcctttgtc tttaagtttg aatcttacac tttcaggtta gtgtttgcgg gggagagagc
     2401 tcagaatacg gaatggtgct aacttgaagc tggaggcatg gaattaacta acctttgggc
     2461 tacccaaatg tgcacattag ctaccatgac atctgtaggc tagcaagctc tttacctagt
     2521 gtttagactg agcagaattt ggagtcaatg agcccaaaag ggtgcaaaat taagatttga
     2581 attatgcatc ttattttatc accatctgct cacgcgaaac agagaatacc tttgaagcac
     2641 aaaaatgtga tcgtttattt gaaacctctg aggtacatac actcagatgc cctttgcagc
     2701 aaggtgtctc tctaagattc ctgtagggaa agcagcccta ctcagtacca gacagcagcc
     2761 ctactcagta ccagatagca ggacagagag aaaagtctat gctagacctc ccctctcagg
     2821 tgtgtgattg gcaggccaaa ccccgattgc caaccagggt ttgtctgctt tattaggaat
     2881 ccagtggcac tatggatgct gacaaaatgc caccatctca gccctcactg ggctgttttc
     2941 taggatatca atagagaaag ggccaactag atccagtatc ctaaaatcct gagagaagaa
     3001 tataagttag cgtgtctcac tgtgataagt gtccctctac atgattgatc acattaatat
     3061 ctaacaatta ccaaatactt actatatgcc caattctgtt gagcatttca tacacaccat
     3121 tggatggaat tctctcaaaa tcctcagaaa agggaattat taatacctcc ataggcaagg
     3181 agcccggagc ccagcgaggt tggttgggca gtctggttaa ggatgtctgc tttgtttaga
     3241 aggaagtgaa aaagaacatc aaactcatat ttattatagc cctggttatt aatgtacctg
     3301 gttacctgct ggatgggaca tcaaggtgga cttttggcac ttgcatatgc ccggtgttat
     3361 ttcggctagt cacggattaa tttcacactc actgtttccc agacatgtgt aggggaagtc
     3421 caggttcgga ggggcctaag attcgtactc tagcttagtt atctaagtct ttaaatccac
     3481 cagctgacct ccccgcacat taatttccct atctaaagag tgagcagtaa ccgagtgata
     3541 cctcctccct tcccttatca ggcactgttg tgggtagggt gcaatgaata cttgataaat
     3601 atgtgtccgt gtgaatcccc acgtgccagc cgctgtcccc aatgcaaaag cagcacagca
     3661 ttcagacatc tcaggctgat ttatcagcag cggatttctc ctagccccat gcctaaagaa
     3721 acttccagcc tagatatgtt gtgtaggttt tgtgtcccag aagcccctac acaggcctca
     3781 acttcactac tgggattgct caggaaactg tacccacaca gaccactttt ctaagaattt
     3841 ggcaaacacc tttgagttta tgctactgtc attgaaaacg ttatcgtgga tgtggagagt
     3901 gcatggtcag cacagtgcca tgggatttga agttctttta aatgtgcttc ctgtttcaag
     3961 gtatttggtg agaagaagct gtttcatgac ctcttcttaa aatagatcca ggtggtgagg
     4021 tgcaaacaga cagcaaatgg tgttcatttt gtaactcaca tgaccacctc actgctacct
     4081 gtcaaagggt acctatcctc ttaacacatc tgagagtgtt taaagaatga gtctgaggct
     4141 tagcaggtaa aagtgcttgt catcacacaa gcctgatgac cagagttcaa acctcagaac
     4201 ccacagtgga aggagaagag agaacccacc cctgaaagtt gttctctgac ctccacatct
     4261 gtgccatggt gtacatacac acacacataa tatatacaca catgcacaca cataatacat
     4321 atccacacat acatacatac atacacacac atacacacat acatacacac acatacatac
     4381 acacacataa tacatatcca cacatacata catacataca tacacacaca tacatacaca
     4441 cacatacata cacacataat atatacccac gcatacatac atacatacac acataataca
     4501 tatccatcca tccatccata catacataca tacatacata tacacacata cacatacata
     4561 cacacaaaca tacatataca cacatataca cacataatac atacccacac atatatacat
     4621 acatacatat acacacatac acaacacatt atacataccc ccacacacat tacatataaa
     4681 agtcgcagtc ctgctgcatg tcttttatta cttttaaagt gaatattaac caagtatttc
     4741 cttggaaatt ctagagcatt ccttaaggtc aattcttatc catgggtttc tgtttgattg
     4801 gtttagttag ttttgttttg ttatgtggag tggttttgtt atatggcttc cttgaggtgg
     4861 ttacaggaac gtggatttgt ggggaaggtg aacttctcag gagaaccact tactttctga
     4921 ggcgctttat attcacgttg ctactggatg ctcttctagc cctggggttg cttgaagctt
     4981 aattttgcca acgtaacagg ttaaagcaag gacactttta agttttccag ttttgatccc
     5041 tggctttgat cctaagccat caactcttcc tgtgacctcg gaatctgtgt ctaatttgtg
     5101 cttcccttcc ctgctctgcc tctagctaag tgttttattt actcaatgat ttaatcattt
     5161 agtttttaag ctacaatgtc ttcacctaca tatggacatc ctaagaataa tactcctctc
     5221 actggactgt cgtatgaaaa ttatgtatac ctgattgaaa aagctgccca agaaacatgc
     5281 atttctttcc ttaacaaata tgaattaaga gtgaataatt atgtaaattc aagtaaatga
     5341 ttttatcaat tttctttgaa gtttatgtta aggtttacct cataaattag aagtttgata
     5401 ctctactatc tgatttgtgg ctttagattc ttcactgtct tagactaaaa tcttttgaac
     5461 aattgtactt taaaaatttt ttttcttttt tctttttttc ggagctgggg accaaaccca
     5521 gggctttgca cttgctaggc aagcgcttta ccactgagct aaatccccaa ctccttaaaa
     5581 ttatttttat tagttgagat atatctcagg aaaatgtact ctgattcaca gtaatgttgg
     5641 agtagaggga gaagctagat tcttactcgt agtgagtcat gtctggtttc tagtctgtaa
     5701 ttcaagtgag gtaggctttc cgaatgacac agacattaat tcttagagcc acttcccacc
     5761 agagattccc gtgggttgaa aacttctgaa tgctagatga tatcttgtca tttctattga
     5821 aatcggtaag tccaactctg tggtaatatt tcccaccaca ccctgcttac agccctttgc
     5881 tatgtctcgg ctcagtgatg caattctcag tgcttcagag aagccacgac tccccgatcc
     5941 tcacggactc aaggggcaag gcaagataca caattataca tgaccaactc tccactaacc
     6001 gcatctccct gagtctttaa aggccttcag atgtgttact ccatagacca ggtaatgagt
     6061 tagcattact catggaatgt agcctaatct tatgcccata ttccaaccac tcgaccgggc
     6121 acatacaacc tttcccagct gctaacatat ttgtttcaca gcttttgcca tcttccaagc
     6181 aacatcccca aacataagga cctaaaacaa ttagtgatgg tctacgattt tctaggttaa
     6241 caatttggac tgatctaagc aggggcctta cctggaaact agtctgaaaa tggcagaaga
     6301 gaaggaaagc cggtatgcac aaggactttg caagcctagg gctgcatcac gttttggttt
     6361 ttatactatt tttaattatt ttctctggat ggtgctttgc ctgaatgtct gtgcagcaca
     6421 tgtgttcagt gcctcagagg ccagaagaag gcgttggatt cccctagaac tggagttata
     6481 gatgcttgta agccatattg tagtggatag gacgtgggta ctgtggagga gaggtagtgc
     6541 ttttacccac tgatctatct ccccagcccc agttgtatca cattgtctaa tgtcaaagag
     6601 agcacatatg tgtagccttt ggtatgtaaa gagaggacat gaagcatgat acttcggagg
     6661 accagaaatg ctctaacagt ctaaaatgtt gagtcgaaca tatcccacaa gtgacagtca
     6721 gggttagctg aactgtccct tcagtggttt tctgctccat ccaacggtag tgtctgttac
     6781 tcttagtcaa atacctttag aatcaacccc attttgtgtt agtcagttta ttctaatata
     6841 aattgaaata aaaatcttgt gactctc
//
LOCUS       NM_001437702            5901 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus lipin 2 (Lpin2), transcript variant 1, mRNA.
ACCESSION   NM_001437702
VERSION     NM_001437702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5901)
  AUTHORS   Kok,B.P.C., Dyck,J.R.B., Harris,T.E. and Brindley,D.N.
  TITLE     Differential regulation of the expressions of the PGC-1alpha splice
            variants, lipins, and PPARalpha in heart compared to liver
  JOURNAL   J Lipid Res 54 (6), 1662-1677 (2013)
   PUBMED   23505321
  REMARK    GeneRIF: novel differences in the regulation of lipins 1,2,3,
            PPARalpha, and PGC-1alpha splice variants during fasting in heart
            versus liver, even though the ultimate outcome in both tissues is
            to increase FA turnover and oxidation.
REFERENCE   2  (bases 1 to 5901)
  AUTHORS   Donkor,J., Zhang,P., Wong,S., O'Loughlin,L., Dewald,J., Kok,B.P.,
            Brindley,D.N. and Reue,K.
  TITLE     A conserved serine residue is required for the phosphatidate
            phosphatase activity but not the transcriptional coactivator
            functions of lipin-1 and lipin-2
  JOURNAL   J Biol Chem 284 (43), 29968-29978 (2009)
   PUBMED   19717560
REFERENCE   3  (bases 1 to 5901)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   4  (bases 1 to 5901)
  AUTHORS   Donkor,J., Sariahmetoglu,M., Dewald,J., Brindley,D.N. and Reue,K.
  TITLE     Three mammalian lipins act as phosphatidate phosphatases with
            distinct tissue expression patterns
  JOURNAL   J Biol Chem 282 (6), 3450-3457 (2007)
   PUBMED   17158099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.35182.1,
                                           SRR26643288.39182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000009.1  118529936-118530127
            193-393             JAXUCZ010000009.1  118566588-118566788
            394-489             JAXUCZ010000009.1  118574295-118574390
            490-791             JAXUCZ010000009.1  118577183-118577484
            792-899             JAXUCZ010000009.1  118583094-118583201
            900-1023            JAXUCZ010000009.1  118584036-118584159
            1024-1363           JAXUCZ010000009.1  118584979-118585318
            1364-1463           JAXUCZ010000009.1  118587525-118587624
            1464-1651           JAXUCZ010000009.1  118591807-118591994
            1652-1745           JAXUCZ010000009.1  118593072-118593165
            1746-1815           JAXUCZ010000009.1  118593540-118593609
            1816-1905           JAXUCZ010000009.1  118595824-118595913
            1906-1988           JAXUCZ010000009.1  118596663-118596745
            1989-2133           JAXUCZ010000009.1  118597611-118597755
            2134-2282           JAXUCZ010000009.1  118598265-118598413
            2283-2369           JAXUCZ010000009.1  118598933-118599019
            2370-2522           JAXUCZ010000009.1  118599579-118599731
            2523-2637           JAXUCZ010000009.1  118600067-118600181
            2638-2741           JAXUCZ010000009.1  118601244-118601347
            2742-5901           JAXUCZ010000009.1  118601637-118604796
FEATURES             Location/Qualifiers
     source          1..5901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..5901
                     /gene="Lpin2"
                     /note="lipin 2"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
     exon            1..192
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    169..171
                     /gene="Lpin2"
                     /note="upstream in-frame stop codon"
     exon            193..393
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2886
                     /gene="Lpin2"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN2"
                     /protein_id="NP_001424631.1"
                     /db_xref="GeneID:316737"
                     /db_xref="RGD:1304588"
                     /translation="MNYVGQLAGQVLVTVKELYKGINQATLSGCIDVVVVRQQDGSYQ
                     CSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAY
                     LATSPIPTEDQFFKHIDPPLVKSSGNERPPQSSDVSHTLESEAVFTPSSVKKKKRRRK
                     KCKQDNRKEEQAASPVAEDVGDVAVSSDDEKRAQAARGSSNASLKEEDYKEPPPFHSG
                     DNYPLSDGDWSPLETSYPQTVCPKSDSELEVKPSESLLRSESHMEWTWGGFPESTKVS
                     KRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCK
                     QLSDAASTELPESPLEAPQISSTLDADPVPSPSAEAPSEPKPAAKVDSPTKRKGVHKR
                     SQHQGPDDIYLDDLKALEPEVAALYFPKSDTDPGSRQWPESDTFSGSQSPQSVGSAAA
                     DSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNL
                     VIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKKESMT
                     KQLPETKEGKSEVPPANDLPSGTEEPVSARPAENDTSSDEGSQELEETIKVDPISMET
                     LSHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDK
                     VIISDIDGTITKSDALGQILPQLGKDWTHQGIARLYHSINENGYKFLYCSARAIGMAD
                     MTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAP
                     SRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVE
                     HVFPLLNKEQNSAFPCPEFSSFCYWRDPIPDVDLDDLA"
     misc_feature    202..522
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    202..522
                     /gene="Lpin2"
                     /note="lipin, N-terminal conserved region; Region:
                     Lipin_N; pfam04571"
                     /db_xref="CDD:461356"
     misc_feature    <1177..1650
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    <1177..1650
                     /gene="Lpin2"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    1600..1878
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    1600..1878
                     /gene="Lpin2"
                     /note="Lipin/Ned1/Smp2 multi-domain protein middle domain;
                     Region: Lipin_mid; pfam16876"
                     /db_xref="CDD:465292"
     misc_feature    2104..2781
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    2104..2781
                     /gene="Lpin2"
                     /note="LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235"
                     /db_xref="CDD:462403"
     misc_feature    2818..>2874
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     misc_feature    2818..>2874
                     /gene="Lpin2"
                     /note="Putative WW-binding domain and destruction box;
                     Region: WRNPLPNID; pfam15017"
                     /db_xref="CDD:464448"
     exon            394..489
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..791
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..899
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1023
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1363
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1463
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1651
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1745
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1815
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1905
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1988
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2133
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2282
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2369
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2522
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2637
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2741
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..5901
                     /gene="Lpin2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtctacc gccagcctgg ccgccgccgc cgccgccgcc gccgccgtgt cccattcatg
       61 aggccccgcg ggctccgctg tggcccgcgg ctcctgaggc ggcggccccg ccccttgctc
      121 gcccgcttct cgccgcagcc cgcccgggcc gcccgacagt ctgccgagtg agagccgcgc
      181 gccgtgccgc agtctcaaac catgaattat gtgggccagc tggctgggca ggtgcttgtc
      241 actgtgaagg aactctacaa gggcattaac caagccactc tatctgggtg catcgatgtg
      301 gtcgtggtgc ggcagcagga tggctcctat cagtgctcac cttttcacgt gcgcttcggg
      361 aagctgggtg tcctgaggtc caaggagaag gtgattgaca tagaaatcaa tggcagtgct
      421 gtggatcttc acatgaaatt gggtgataat ggagaagcct tctttgtaga ggagactgaa
      481 gaagaatatg aaaaactgcc tgcttatctt gccacctcac caattccaac tgaagaccag
      541 ttctttaaac atattgaccc ccctttggtg aaatcaagtg gaaatgaaag gccaccacag
      601 agttcagatg tttctcatac cttggaatca gaggcagttt tcactccgag ttctgtgaaa
      661 aagaagaaac ggaggagaaa gaagtgcaaa caggacaata ggaaggagga gcaggcggct
      721 tcccctgttg cagaagatgt aggcgatgtg gctgtgagct ctgatgatga gaagagagcc
      781 caggcagcaa gaggatcttc aaatgcttcc ttaaaggaag aggactataa ggagcctccg
      841 cctttccatt ctggggataa ctatccctta tctgatggag attggtctcc attggaaacc
      901 agttacccac agacagtgtg ccccaagagt gactcggagc tggaggtgaa gccatccgag
      961 agcctcctca gatctgagtc gcacatggag tggacgtggg gtgggttccc agagtccacc
     1021 aaggtcagca aaagagaaag atatgactat catccaagga cagctacaat tacaccatca
     1081 gaaaacactc attttagggt aattcccagt gaagacagcc tcataagaga agttgagaag
     1141 gatgctactg ttgaagatac tacctgtacc atagtgaaac ccaaacctcg agccctgtgt
     1201 aagcaactga gtgatgcagc ttccactgaa cttcctgaat cgcctcttga agcacctcag
     1261 atctcatcta cattagatgc agaccctgtt cccagcccat cagcagaggc tccctcagag
     1321 cccaaaccag ctgctaaagt agactcacct acaaagagaa aaggtgttca caaaagaagc
     1381 cagcaccagg gacctgatga catttacctt gatgacttaa aggctcttga gcctgaagtg
     1441 gcagctctct atttccctaa aagtgacacc gatccgggtt ctaggcagtg gcctgagtct
     1501 gacacattct ctggttctca gtccccacaa tctgtgggaa gtgcagctgc agacagtggc
     1561 accgaatgcc tctcggattc tgccatggac ttgcctgatg taactctctc cctctgtgga
     1621 ggcctcagtg agaatggaga gatttctaaa gagaagttca tggagcacat catcacgtac
     1681 cacgagtttg cagagaaccc tggccttatc gacaacccga accttgtgat ccggatctat
     1741 aaccgttact acaactgggc gttggctgct cccatgatcc ttagcttaca ggtatttcag
     1801 aagagtctgc ctaaggccac agtcgagtcc tgggttaaag acaagatgcc gaagaaatct
     1861 ggccggtggt ggttttggcg aaagaaagaa agcatgacca aacagttgcc ggagaccaag
     1921 gaggggaaat ctgaggtccc tccagcaaat gacctgcctt ccggtactga ggagcccgtc
     1981 agtgccagac ctgcagagaa tgacacttct agtgacgagg ggtcacagga gttagaagaa
     2041 accatcaaag ttgaccccat ctcgatggag acattgagtc actgtggaac agcctcatat
     2101 aagaagtctc tccgactgtc ctcggaccag atagcaaaac tgaaactcca cgatggcccc
     2161 aatgatgttg tattcagtat cacaacccag tatcagggca cctgtcggtg tgcgggtacc
     2221 atttacctgt ggaactggaa tgacaaagtc atcatttctg acatcgatgg aacaataacc
     2281 aagtctgatg ctttgggaca gattctccca cagctgggta aagactggac tcatcagggc
     2341 atagctaggc tctaccattc catcaatgag aatggttaca agtttctgta ctgttctgca
     2401 cgcgccatcg gcatggccga catgacccgt ggctatttac actgggtcaa tgacaagggc
     2461 acaatcttgc ctcgaggccc cctgatgctg tcccccagca gcttgttctc tgccttccac
     2521 agggaagtga tagaaaagaa accagagaag ttcaaaattg agtgtctgaa tgatattaag
     2581 aacttgtttg ccccatccag gcagcccttc tatgctgcct ttggaaaccg tcccaacgat
     2641 gtctatgctt acacacaagt cggagttcca gactgtagga tattcactgt gaatccaaag
     2701 ggtgaattaa tacaagaaag gaccaaagga aacaagtcat cgtatcacag gctgagtgag
     2761 cttgtggaac acgtgttccc acttctcaat aaggaacaga attctgcctt cccatgccca
     2821 gagttcagtt ccttctgcta ctggagagac ccaatccctg acgtggacct ggatgaccta
     2881 gcttgaaaaa ggcctgtggc aaggtggggg cactgtcact cacctcccag cagggaaggt
     2941 cactggccct cttacagatg aagacccagg agctgacagg aacctgcttt ccagaacagg
     3001 gacagagtcc ccgaagctgg cactgccacc ttctttcagc ttcctaagcc accactcagc
     3061 acctagacag aggagtaagg ggcagtcagc ctgcattaga agcctgtgct ctgaagcctg
     3121 tgctccatta cttgtgggcc tcacatgcct cttgtggagt tgtgtgctgt gcactggtca
     3181 gctgcatagt ttaaaaagga agaaaccaga aactcaaaaa gaacagacca gcacatgact
     3241 acacaaagta aagagttaaa atctccactg gtcagttggg atcgtttctc tctataaaca
     3301 gggctttctg cagaggtcca gttagtgctg ccagctgtgt gtacatgtcc tcctccggac
     3361 acctccactc ctgctcactg aactaggaca gctgcttcat gtgccaggca ggcagcgcca
     3421 gcaccttgag cccagctgcg ccagcgtggg ctgtaaagtt gggggaaggc agcctagcag
     3481 caccatctcc tcgctgagaa ggaagtcgtt taggttgtcg ttatgaccta gcagaagaac
     3541 aggtgcatat ttcatgtctg gagtaacagt gaggccttgg tttaaatcac aggagaggca
     3601 gtggctttcc tcagaagtgt agggcagttg ccttgggcct tgggagtcct gttctctgac
     3661 actgtcactg ccttaggtgg tccttggggc aggtatttca ggacaggatt tttgaaagtc
     3721 tgggcttcag atttgctaag gaaaaagcct ttggctggtg gcattgacca gtcctttgaa
     3781 ctccagccac ataagaagtc catggaggcg tgggagagag ggcactgagt gcccgttgag
     3841 agcgagcacc gcggcaggag cccagcccac ctgattcacc tgtcagctct gaccctcatg
     3901 cagttgatag tgggctaccc ctgcacctcg ctgcacctcg ctggcagcac cagacactgg
     3961 cctagttaag tgcttgtcaa tgttggaaca cacagcacca gggagagttt tgtcctcaga
     4021 tctgcagagc cgggaccagc tgggtgtgga cagtcactgc agtgctcaca tcgagaagta
     4081 ctgaaggagg gcgttccaga gacctcagtg gttcagtcac aacctcccct gggaagatgg
     4141 ccgtggcggc ttctgagcag agggggagcc gcccttaaag ctgttccaac cctgcatgcc
     4201 ctgcagctgg atggctggcc tgaccaggct tcagtttgct tcactcaaaa taacgctcgc
     4261 ctagagttgg cttagaaaag gggtggttat tttccagatt ggagagttga gtgtccctgc
     4321 ctcatttcag tattgcagtt gaatgcagag accatggttg acaatgttta attaaagaaa
     4381 aaaaggacca tgtgaagcac agttctcagt ggcaaacctg aaggtacatg ctcccagaga
     4441 aggggccaca caggcttcca cagctgatgt ttcccataca attcacttct ccttcgtgag
     4501 ttatctgtgt taggtagtag ggaaactcag ttacgtttat gtgaaattct tgccggttag
     4561 tgaaataaga tcctattaaa gcagccacgt gggatttgat gcccaagcca tcagtacctt
     4621 ggtggtgtag cacatcttcg ctttagggaa gcagaattgt gtacttaacc tgagcttggt
     4681 aggatctcgt ggtacagaat gtcttttatg ttttctctca gaccacttct gtttgtcctt
     4741 tagggagctt tttacctagc tagtctgttt gcttttcctg acaaactctt tttttttttt
     4801 tttttttttt tttggacaca tgggcctctt cagaaggtcc agcataggct ctgggtctct
     4861 tggcctgtgc cgagagggtg gctggtcttt ctgtccgtct gtgtgtctgt tagcccgaca
     4921 cttgtcactg cacattgatc agtgaatatt taggataatg aatgtaactc tttccttatt
     4981 taaaggagtc ttccttgctg aaagtagatg attactgtta ctgtagtgtt atgagtgtta
     5041 ggtttgtgct gaaaatccat tgccatttgt tacaaatgac atttgttctt tctgtgaaag
     5101 agagatgccc ttaagtgtgt ttgcacacaa acccttagat ggcttgttgc agtgtcacct
     5161 tgtcttcagt gacaggtgat gctgaagaga cactatggca gaccagccac ccgtccctcc
     5221 atcagtgttg catcagtgac tacggcccca tgtctttcca gttcagtcta atgttagtgt
     5281 ctggtgtcga gtgttggcac ttccactgct gtggaagtga tggctgctct ccctgtggag
     5341 gttgtacatg tggacctgga gcacacacac gtaaccgtat gatcagtact gcatttcctg
     5401 tggtctatct gcatagtcag ttggaaaaag aaatgtgttg gtgtagtaac gtaaaaacaa
     5461 aagctgctaa aacagcctag agtgggtcag gaccacagct gagcagcagg gagcctctgt
     5521 cctgtgcagc ccctgtccat ggggcgggtc cggccttctg tagtgctctt caaagccatc
     5581 atccgagaga agaagcggtt aaggtgacga gcgagtttat cacatagccc tgggaaacct
     5641 tgtttgagag cacgctgggg tttatgcaaa acttgaaggc agaggaaaga cttccctttt
     5701 aataattaca ctcagctgat gaaggacttg attattagag agcagccact gagcagcttt
     5761 cagtcgtcag taatgaattg taaacatcag tgcagtacct tcaatgtggt acagaagttg
     5821 tcttcagatg aacggctcat gttttggtgc agtgtttgat gttcacaaaa atgttacaat
     5881 aataaactaa cgtgaactga g
//
LOCUS       NM_001438052            2013 bp    mRNA    linear   ROD 17-APR-2025
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), transcript variant
            1, mRNA.
ACCESSION   NM_001438052 XM_006231493
VERSION     NM_001438052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 15, 2025 this sequence version replaced XM_006231493.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.910088.1,
                                           SRR26360190.2736670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000001.1  254838799-254839081 c
            284-386             JAXUCZ010000001.1  254829899-254830001 c
            387-431             JAXUCZ010000001.1  254829728-254829772 c
            432-507             JAXUCZ010000001.1  254829533-254829608 c
            508-610             JAXUCZ010000001.1  254829330-254829432 c
            611-783             JAXUCZ010000001.1  254829031-254829203 c
            784-906             JAXUCZ010000001.1  254828414-254828536 c
            907-990             JAXUCZ010000001.1  254828151-254828234 c
            991-1114            JAXUCZ010000001.1  254827934-254828057 c
            1115-1263           JAXUCZ010000001.1  254827574-254827722 c
            1264-2013           JAXUCZ010000001.1  254826138-254826887 c
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2013
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     exon            1..283
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1494
                     /gene="Ldb1"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     domain-binding protein 1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 1"
                     /protein_id="NP_001424981.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQV
                     PDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNS
                     KPPSSQESKSENPTSQASQ"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    466..1071
                     /gene="Ldb1"
                     /note="LIM-domain binding protein; Region: LIM_bind;
                     pfam01803"
                     /db_xref="CDD:426444"
     misc_feature    1264..1350
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     misc_feature    1264..1350
                     /gene="Ldb1"
                     /note="LIM interaction domain (LID); Region: LID;
                     pfam17916"
                     /db_xref="CDD:465564"
     exon            284..386
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..431
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..610
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..783
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..906
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..990
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1114
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1263
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..2013
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacactccg gggacgcaca cccgcgcgta cacacgcaga ggcagctcgc cttcctgcct
       61 ggcttccttc ctgtttgctc cgcgcctgac aggcccctcg ctgcaggcag gggcggcccg
      121 caccgggcaa aggccgggcc gggccggcgg cgcgggcaac gggggccgcg ggcggcggca
      181 gcggctcatg cccagcctgt ccctgcgagg ggcgggcatc gtgactcggc tgggccccca
      241 gcagcgggcg atgtgaagat gtcagtgggc tgtgcctgtc ctggttgttc ctcaaagtca
      301 ttcaagctgt actccccgaa ggagcccccg aacggcaacg ccttccctcc cttccatccc
      361 ggcaccatgc tggatcggga tgtgggccca actcccatgt acccacctac atacctggag
      421 cctgggatag ggaggcacac gccatatggt aaccagacag actatagaat atttgaactt
      481 aacaaacgac tacagaactg gacagaggag tgtgacaatc tctggtggga cgctttcacg
      541 accgagttct tcgaggatga tgctatgctg accatcactt tctgcctgga ggatggacca
      601 aagagatata ccattggccg gaccctgata ccacgctact tccgaagcat tttcgagggg
      661 ggtgctacgg agctgtatta cgtacttaag caccccaagg aggcattcca cagcaacttc
      721 gtgtccctcg actgtgacca gggcagcatg gtgacccagc atggcaaacc catgtttacc
      781 caggtgtgtg tggaaggccg gttgtacctg gagttcatgt ttgacgacat gatgcggata
      841 aagacatggc acttcagtat ccggcagcac agagagctca tccccaggag tatcctggcc
      901 atgcacgccc aggaccccca gatgttggat cagctctcca aaaacattac ccggtgtggg
      961 ttgtccaatt ccactctcaa ctacctccga ctctgtgtga tactggagcc catgcaggaa
     1021 ctcatgtccc gtcacaagac ctacagcctc agcccccgag actgcctcaa gacctgcctt
     1081 ttccagaagt ggcagcggat ggtagcacct cccgcggagc ctgcacgaca gcagcccagc
     1141 aaacggagga aacggaagat gtcagggggt agcaccatga gctcgggggg cggcaacacc
     1201 aacaacagca acagcaagaa gaagagccca gccagcacct tcgctctctc cagccaggta
     1261 cctgatgtga tggtggtggg ggagcccacc ctgatgggcg gggagttcgg ggacgaggac
     1321 gagaggctca tcactcggct ggagaacacc cagtttgacg cggccaacgg cattgacgac
     1381 gaggacagct ttaacaactc ccctgcactg ggcgccaaca gcccctggaa cagcaagcct
     1441 ccgtccagcc aagaaagcaa atcggagaac cccacgtcac aggcttccca gtaaaggccc
     1501 taccacggcc acccaggtct ctgcctgcta cccctcacag ctccagggag cagaagccag
     1561 aacgaagaga ctgggcgtct gaaatgggca acctccatct acccacttca gggagggact
     1621 ggactcgctg ggggcaggtg ccaagatttg cccccgagtt gccctgggct gggcctggcc
     1681 cctgcagagc cttttggggg aagggggtac tcatgtggat gcctatatgg accctgggct
     1741 tctgagaaat gtcctgaccc tcctctcccc agggcatttg tccccattcg taccccaggt
     1801 tctgggtacc ccatcttcct gatttatccc tttgagcctg gggtttatac ccacagccct
     1861 taggggctaa atgttggggc cttggttgaa tgccctttcc cctaggcggc tgtcaacaga
     1921 gggtaaaatt ctgggctcct cccttttgcc acttacccag ctccaagttt ttaaaaaaaa
     1981 ataatattat taaaaatgta aattaaaaaa aaa
//
LOCUS       NM_001438432            2018 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus activating transcription factor 7 interacting
            protein 2 (Atf7ip2), transcript variant 3, mRNA.
ACCESSION   NM_001438432 XM_008767495
VERSION     NM_001438432.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 18, 2025 this sequence version replaced XM_008767495.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.35435.1,
                                           SRR26643293.61368.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000010.1  5952676-5952742     c
            68-255              JAXUCZ010000010.1  5944704-5944891     c
            256-374             JAXUCZ010000010.1  5941144-5941262     c
            375-509             JAXUCZ010000010.1  5939114-5939248     c
            510-608             JAXUCZ010000010.1  5937462-5937560     c
            609-763             JAXUCZ010000010.1  5937050-5937204     c
            764-834             JAXUCZ010000010.1  5929393-5929463     c
            835-896             JAXUCZ010000010.1  5927677-5927738     c
            897-963             JAXUCZ010000010.1  5926581-5926647     c
            964-1116            JAXUCZ010000010.1  5914513-5914665     c
            1117-2018           JAXUCZ010000010.1  5909933-5910834     c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2018
                     /gene="Atf7ip2"
                     /note="activating transcription factor 7 interacting
                     protein 2"
                     /db_xref="GeneID:497859"
                     /db_xref="RGD:1583744"
     exon            1..67
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..255
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Atf7ip2"
                     /note="upstream in-frame stop codon"
     CDS             78..1292
                     /gene="Atf7ip2"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="activating transcription factor 7-interacting
                     protein 2 isoform 3"
                     /protein_id="NP_001425361.1"
                     /db_xref="GeneID:497859"
                     /db_xref="RGD:1583744"
                     /translation="MESPDRKRRKVLKAKKTMPTSCRKQMEILNQSKNVEAPKTTVVT
                     NIPNGNQSLGTGFIASHNQKMFSENKENVKVMKTSEQINENACEALERHTALLEQVKH
                     WIRQEICTINCNLFDKKLNELNERIGKTQCRSKHEAIAGELFIKIRRLQKRIKTVLSS
                     QGNCLEPNTLPSNTVCKVTDSVNLSVTQRSVKSQSKRMSSVNHTPFNSSEKASRKINL
                     PSACVEFVSESNDDVMLISVENPNLTTPIASDPTEIRKNTSRNVSSSPNARSEVVPVE
                     KKFDFVIDLTREGLSSYSIGPPSSRLHHLRIAPSAEDQAFNTGAFGDHSNSRVQQIGT
                     KPSTRRKKIPVKEKENLQQENTTRRGDGGGYSRVQKSELTGTRPPGMSSSSSDNRKGF
                     NTSFLNQNRTLP"
     misc_feature    285..911
                     /gene="Atf7ip2"
                     /note="ATF-interacting protein binding domain; Region:
                     ATF7IP_BD; pfam16788"
                     /db_xref="CDD:465271"
     misc_feature    285..911
                     /gene="Atf7ip2"
                     /note="ATF-interacting protein binding domain; Region:
                     ATF7IP_BD; pfam16788"
                     /db_xref="CDD:465271"
     exon            256..374
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..509
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..608
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..763
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..834
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..896
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..963
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1116
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2018
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgggggtc attttgtctg gggtctcagc tctcgctgag ggcttctgag gaccggcggc
       61 gctctaggat atgaaatatg gaaagtccag acagaaaaag acggaaggtt ttaaaggcca
      121 agaagacaat gcctacaagt tgccggaagc agatggagat cctgaaccag tcaaagaatg
      181 ttgaagctcc aaaaacaaca gttgtgacta atattccaaa tggtaaccag agtttaggta
      241 ctgggtttat agctagccat aatcagaaga tgttttcaga aaacaaagaa aatgttaagg
      301 tcatgaaaac ttcagagcaa attaatgaaa atgcttgtga ggctctggaa aggcatacag
      361 cactgctaga acaggttaaa cattggattc gacaggaaat ctgcacgata aactgtaatt
      421 tatttgataa aaaactgaat gaattgaatg aacgcattgg gaagacccag tgcagaagta
      481 agcatgaagc aatagctggt gaactcttta taaaaataag aagacttcaa aaacgtatca
      541 aaaccgtatt atcatctcaa ggaaattgtt tggaaccaaa cacattaccc agtaacacag
      601 tttgtaaggt tacagattct gtgaatttga gtgtgaccca aaggtcagtt aaaagtcaaa
      661 gtaaaagaat gtcttctgtg aaccatacgc cttttaactc ttcagaaaaa gcaagtagaa
      721 agattaattt gccatcagct tgtgttgagt ttgtttctga aagtaacgat gatgttatgt
      781 tgatttctgt ggaaaatcct aatttgacaa ctccaattgc atcagatcca acagaaatta
      841 gaaaaaatac atcaagaaat gtcagcagtt ctcctaatgc caggagtgaa gttgtgcctg
      901 tagagaagaa atttgacttt gttattgacc tgacaagaga aggcctgtcc agctacagca
      961 taggccctcc ttcatcaaga ttacaccatc tccgaatagc accatcagct gaggaccaag
     1021 ccttcaacac aggggccttt ggggaccatt ccaattccag agtgcaacag atagggacca
     1081 agccctccac caggagaaag aagattcctg tgaaagaaaa agaaaatctt cagcaagaga
     1141 acaccactag aagaggagat ggaggaggct acagcagggt acagaagtca gagcttacag
     1201 gaacccgacc tccaggaatg agttcctcca gcagtgacaa caggaaaggt ttcaacacct
     1261 cctttctgaa tcagaaccgg accttacctt gaccaaggct gcttaactac gttatgtcca
     1321 tgtcaaagcc tttaaaagaa gagcacttag tgattaaacc tgctccagtg actctaggac
     1381 agtgaagtcc tgtacagcta tgactggaac tgggtagagt taatactata cagaagctgg
     1441 agaggtagcg gcattcttgt tgggtgtgtg caaagcagtc agtgggcgct ctttctgtga
     1501 tcaccgtttg agacagtgcc tggtgtgctc aggttagtct taacccactg tggactcaag
     1561 ataaccagca cacgttttga tgtttctggg gtccgtgtaa ccattctgat ggaccccacc
     1621 accatcagcc agcctgatag ctcggctcgc tctcccctgg ctgccatctg tctgttggca
     1681 ttgactcatt gcgtgtctcg tgggtagcta aggaacactt gacatcaaga accaaatctg
     1741 gatagcttgt gctgttcctt gcgcttggag atttgaacat taacatgtcc ttgacaaatt
     1801 atgtcttccc ttaacctgaa acaagaatgt aaatgggtgg ctgggaagaa aatgaggaca
     1861 actgggagag ctagcataaa gctgtcaatc aaccattttc ttcaagtgtc aaatgcagtg
     1921 gaaagaactg tttatctgca agactagcca tgacagtctt aagtcttcgt catctgaagt
     1981 tttgatcctt gttttacaat taaattcatg aaaaattg
//
LOCUS       NM_022389               2601 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7),
            transcript variant 5, mRNA.
ACCESSION   NM_022389
VERSION     NM_022389.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_022389.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272393.1, SRR26643429.4225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680414, SAMN06680437
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  208444568-208444623
            57-184              JAXUCZ010000001.1  208447533-208447660
            185-397             JAXUCZ010000001.1  208450269-208450481
            398-620             JAXUCZ010000001.1  208451583-208451805
            621-711             JAXUCZ010000001.1  208452757-208452847
            712-925             JAXUCZ010000001.1  208453456-208453669
            926-1130            JAXUCZ010000001.1  208455552-208455756
            1131-1262           JAXUCZ010000001.1  208457746-208457877
            1263-2601           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2601
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..56
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            57..184
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    159..161
                     /gene="Dhcr7"
                     /note="upstream in-frame stop codon"
     exon            185..397
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1727
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_071784.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     misc_feature    417..479
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    576..1724
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    576..1724
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    594..656
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    741..803
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    828..890
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1008..1070
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1095..1157
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1215..1277
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1290..1352
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1557..1619
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     exon            398..620
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            621..711
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            712..925
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1130
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1262
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2601
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttag ggcgctgctg gagctcgtga atcaaccgcc cggatcccgc acgcagagtg
       61 ttactcagca tatgggcaag gattgatcag accttggggg acttctgaac ctggacattt
      121 tgagagccac ttttgagaaa gacaacatca ttctattgtg aaacctgtgg cccagaggtc
      181 aaagaacctg cggtgggcga tcaggtactg agaaagctac caaggttgcc tgctctactc
      241 agcacttgag ccctggtggg ggtctatctt tctggaagga tctgagcctc tcctccttcc
      301 ctcagatcct gatggcttca aagtcccagc acaacgcttc caaagccaag aatcacaacg
      361 tcaaggctga atctcaagga caatggggcc gtgcctggga agtggactgg ttctccctgg
      421 tcagcgtcat tttcctgctg ctcttcgcac cgttcattgt gtactacttc atcatggcat
      481 gtgaccagta cagctgctcg ctgactgccc ccatattgga cgtagctaca ggccgtgcga
      541 gtctggcaga catctgggcc aagacaccgc ctgtgacagc taaggctgcc caactgtatg
      601 ccttgtgggt cagcttccag gtgctgcttt actcctggct tcctgacttc tgccacagat
      661 ttctgccagg ttatgtggga ggcgtccaag aaggtgccat aactccagca gggattgtaa
      721 ataagtatga ggtgaatggg ctgcaagcct ggctcattac ccacttcctc tggtttgtga
      781 acgcttacct cctatcctgg ttctccccca ccatcatctt tgacaactgg atcccgttgc
      841 tatggtgtgc caacatcctg ggctacgctg tgtccacctt tgcaatgatc aaggggtacc
      901 tgttccccac cagcgccgaa gactgcaaat tcacaggcaa tttcttctac aactacatga
      961 tggggattga gttcaacccc cgcatcggaa agtggtttga cttcaagctg ttcttcaatg
     1021 ggcgcccggg gattgtggcc tggactctta tcaacctgtc ctttgctgcc aagcagcagg
     1081 agctttatgg ccatgtgacc aactccatga ttttggtcaa tgtcttacag gccatctatg
     1141 tgttagactt cttctggaac gaaacctggt acctgaagac cattgacatc tgccatgacc
     1201 actttggatg gtacctgggc tggggagatt gcgtgtggct gccctacctc tacacactgc
     1261 agggcctgta cttggtgtac caccctgtac agctctccac ccccaacgcc ttgggcgtcc
     1321 tgctgctcgg cctggtgggt tactatatct tccgaatgac caaccatcag aaggacctgt
     1381 tccgccggac agatggacac tgcctcatct ggggcaagaa acccaaggcc atcgagtgct
     1441 cctacacgtc agccgacggg ctgaagcacc gcagcaagct gttggtttca ggcttctggg
     1501 gtgtggcccg ccacttcaac tataccggag acctgatggg cagcctcgcc tactgcctgg
     1561 cttgtggcgg cggccacctc ctcccctact tctacatcat ctatatgact atcctgctta
     1621 cccaccgctg cctccgtgat gagcaccgct gtgccaacaa gtatggccgt gactgggagc
     1681 gctacgtagc cgctgtgccc taccgcctgc tgcctgggat cttctgaggg ccaccctggc
     1741 aagcagaaag aggcgtcatt gaatgtgtgg agttgggtgc atgggggcca gcgtccggct
     1801 ttcccctgca ggggcctcct tggtttgctc ttctggagga tggagagcca ggcgccccac
     1861 agtgtctggc tggtggcagc tagagctgag ttcacactga tgccccagca gaatgactgg
     1921 ttctccctgt tcagcatcct gagggcagag gaccttggcc ctttcatgtc tgttggaagc
     1981 ccaccatcta tgttgtctag atagcttagg cttaccaggt gtctcccagg attgggccat
     2041 cctggtaaac tggagacaat gtaggatcta aagagtttgg caatgtcacc ttcactccca
     2101 cctgcaatgg tgggctggac ccctttttct gtctgtagtg tgatcagcag agggttcagg
     2161 ggccattgaa ggaggaaggc tctttgttta ggttctttac tgtttttacc cgaggaatgc
     2221 caagcagcgg actggaatat cccactctgc acatccctgg ctgacttgat aaagtctgtc
     2281 tgacatatga gatggggttc ccagaactcc ccaagtaccc cagctagcag cttatccatc
     2341 tcccctcttc cggaaggtgc ttcttgttta cccctgagac ttggctcaga ggtgaacaga
     2401 cttggctctg acaacccaga atgtatcacc agttagtggc ctcagccaca ccttccccaa
     2461 caggagaacc agcgttgggg aaggaatcca ttctcattag tgacactgcc ccccaaaact
     2521 cagggttatt ttgtaaaact agataggctc atgttagcct tgcaagcggt tctttgtatt
     2581 aaatctgcct tgttaaatga g
//
LOCUS       NM_001438409            1489 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 8, mRNA.
ACCESSION   NM_001438409
VERSION     NM_001438409.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.5373.1,
                                           SRR26643298.6868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JAXUCZ010000001.1  213562696-213563231
            537-719             JAXUCZ010000001.1  213563668-213563850
            720-1489            JAXUCZ010000001.1  213564268-213565037
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1489
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..536
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    341..343
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="upstream in-frame stop codon"
     CDS             419..736
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 8 is encoded by transcript variant 8; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 8"
                     /protein_id="NP_001425338.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMF
                     QIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGDG
                     AGR"
     misc_feature    545..>730
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    545..>730
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    617..619
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     exon            537..719
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1489
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcagg ccccgcgctc cggcctgcag cagagcccct tagagcccca cggctcgccc
       61 tcctgggctc ccctgtccat tcttccgcac ccgggcggcc atcctgccgg aaaggagctc
      121 ccgagatggc gcggggagtt gtccccaagg caggtagtgc aaggcttcca cgaccgggag
      181 gaggaaggag ctggtcttcc catcccggtc actcggtcca ggggaagcaa taaccatcgc
      241 aaagatcatt gcatccgacg gccaagcttc agtgaatgac tctataagta atcactaagc
      301 tgtttacaga gttttcacta gctcctcagg gaggtgtcat tagccccatt ttacaggagg
      361 aattcaggcc cagaagggct ggaggactta tcagccgaag caggcctcca ggatccaaat
      421 gggaacccca aagcagccct cgctggctcc tgcacacgcc ctaggcttga ggaagtccga
      481 tcccggaatc cggagcctgg ggagcgacgc gggaggaagg cggtggagac cagcagccca
      541 gagtatgttc cagatcccag agtttgagcc gagtgagcag gaagacgcta gtactacaga
      601 taggggcctg ggccctagcc tcactgagga ccagccaggt ccctacctgg ccccaggtct
      661 cctggggagc atcgttcagc agcagccggg acaggcagcc aataacagtc atcatggaga
      721 tggagcaggc aggtgaccct aagtgacaag ccagagccgt gtgaagttgg aaagaggaag
      781 acggagaggc gttggaagac actggttata ctttccactt cccatcgctg accccgtaac
      841 agccacagaa acctgagctc aaccaggttt gtcactggct ccatagagct taaattatcc
      901 ctaccccatt atgtttccct gaactgcttc aagctcccac acagctgaga ctggcctcta
      961 cctcccaagt actaggacca caggccaccg tgcctggcat tccaccttct ttttaaaatt
     1021 atgtgtatat gtgtgccatt gtaaaatgca catgtgcaag tgtgggggcc ttgcaagcca
     1081 gaagagggcg ctggatcccc taaagctgga gttacaggtg gttgtgagct gccccacctc
     1141 tttgctggga actgaactca tgtcctctgc aagagcagca aatgccctga acgactgagc
     1201 catttttcca gtccccaccc cttttaacct tcaggtttct ttattatcat catcatcatc
     1261 atcatcatca tcatcatcat catttatttt tttgtttttc aagacaaggt ttctctatgt
     1321 atccctggct gtcctggaac tctctcttta gaccaggcta gcctggaact cagagatctg
     1381 cctctgcctc ccagtgtggg gattaaagac atgcactgcc actgctgagc aatctccaga
     1441 tttctttttc tttccttttt aaaaaaaata aaatgtttat ttaatgtga
//
LOCUS       NM_001438408             849 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 7, mRNA.
ACCESSION   NM_001438408
VERSION     NM_001438408.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 849)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 849)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1448324.1,
                                           SRR26360186.864609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000001.1  213563363-213563416
            55-237              JAXUCZ010000001.1  213563668-213563850
            238-384             JAXUCZ010000001.1  213564268-213564414
            385-575             JAXUCZ010000001.1  213570794-213570984
            576-849             JAXUCZ010000001.1  213571761-213572034
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..849
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..54
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..237
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..384
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    372..374
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="upstream in-frame stop codon"
     exon            385..575
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..746
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 7 is encoded by transcript variant 7; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 7"
                     /protein_id="NP_001425337.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="METRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRY
                     GRELRRMSDEFEGSFKGEELTYSVEFLPVRAIAMEGWPLLWSFQSFPHTLPPTPPEVA
                     MFPLRYWTALRRLC"
     misc_feature    <396..>578
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    <396..>578
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            576..849
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactggag agaggaggca ggcccgagtc aggggcctcg agaacgggct tgggcccaga
       61 gtatgttcca gatcccagag tttgagccga gtgagcagga agacgctagt actacagata
      121 ggggcctggg ccctagcctc actgaggacc agccaggtcc ctacctggcc ccaggtctcc
      181 tggggagcat cgttcagcag cagccgggac aggcagccaa taacagtcat catggagatg
      241 gagcaggcag gtgaccctaa gtgacaagcc agagccgtgt gaagttggaa agaggaagac
      301 ggagaggcgt tggaagacac tggttatact ttccacttcc catcgctgac cccgtaacag
      361 ccacagaaac ctgagctcaa ccaggcgctg ggactatgga gacccggagt cgccacagtt
      421 cgtacccagc ggggactgag gaagatgaag ggatggagga ggagcttagc ccttttcgag
      481 gacgctcgcg ctcggctccc cccaatctct gggcagcgca gcgctatggc cgtgagctcc
      541 gaagaatgag cgatgaattt gagggttcct tcaagggaga agagctgacg tacagcgttg
      601 agttccttcc ggtgcgtgca atagccatgg aggggtggcc cttgctttgg agttttcaaa
      661 gttttccaca caccctaccc cctacgcctc cggaagtggc tatgttccct ctccgttact
      721 ggacagccct caggcgcctg tgctaagttg cgagtcctgg taaaccgaga ctgggtgctg
      781 tcctatcatc ctagctggag gccccaggtc gggagaaacg tgctttataa taaagcccgc
      841 gcatgtgtc
//
LOCUS       NM_001438315            3705 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 2, mRNA.
ACCESSION   NM_001438315 XM_017588939
VERSION     NM_001438315.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_017588939.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2190121.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-780               JAXUCZ010000001.1  144815553-144816332 c
            781-955             JAXUCZ010000001.1  144794240-144794414 c
            956-1144            JAXUCZ010000001.1  144734138-144734326 c
            1145-1368           JAXUCZ010000001.1  144723344-144723567 c
            1369-1621           JAXUCZ010000001.1  144721538-144721790 c
            1622-1735           JAXUCZ010000001.1  144719060-144719173 c
            1736-1789           JAXUCZ010000001.1  144718708-144718761 c
            1790-1926           JAXUCZ010000001.1  144717593-144717729 c
            1927-2125           JAXUCZ010000001.1  144714015-144714213 c
            2126-2220           JAXUCZ010000001.1  144712661-144712755 c
            2221-2301           JAXUCZ010000001.1  144711957-144712037 c
            2302-3705           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3705
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..780
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    337..339
                     /gene="Cpeb1"
                     /note="upstream in-frame stop codon"
     CDS             652..2400
                     /gene="Cpeb1"
                     /note="isoform 2 is encoded by transcript variant 2; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 2"
                     /protein_id="NP_001425244.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MAPLKLSIRAPRAGRALSEPGEVTWLHTFDCFWSPSPEGGPDQE
                     EESGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSLDFSKVCTTPINRGIHDQLPD
                     FQDSEEAITSRMLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSSAQS
                     NTQSVLSMLQNPLGNVLGKTPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDSRSS
                     SPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQEQAA
                     LAAVAPSPTSAPKRWPGTSVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCTWSG
                     QLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGYVYLVFELEKSV
                     RALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSR
                     TVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAV
                     TAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHS
                     MEGLRHHSPLMRNQKN"
     misc_feature    775..1683
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    775..1683
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1687..1959
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1687..1959
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1990..2241
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    1990..2241
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    2221..2388
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    2221..2388
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            781..955
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1144
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1368
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1621
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1735
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1789
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1926
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2125
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2220
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2301
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..3705
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctcgct gcaaaaatag tgcccacgtg tgtgcgcgtc ccgcgccgca cagacccgcc
       61 ggcccgcccg ccagtccctt agggccacgc cggaccccat ggctttttct ctggtaagag
      121 ccgccggggc ggggcggggc cgggcggggc tgctgtccct gccgcctcag ctaacggtcc
      181 gcgcgcagtc tcgctgcctc acaggccccc accgccgccc gggttagcgt cccgggcggg
      241 gcgccggtca catgcccgcg gtcgtgggcc tcgtggagcg gtgtggggcg cgcggggagg
      301 ggcagggagc ctcctcgtga ctcaggcctt tgggcttaaa ggcgccgcgg ccctccgggg
      361 gcggccgctg gggcctcgga gctgcgcttg cagactctcg gtggcttcga acatacgtcc
      421 agaccggagc tggcggcgcg gacgggagcc cgggcgccca caacagttcc tcctcccgca
      481 gccgtcgcac gtgagagccc gagcggccgg cagtgccggc gtctctcgag agtcgccttg
      541 gcgtcccgca ggagacagga gccggcggct cgctgcgggc cgcacagtga gcagcggaga
      601 ccccctcagg ctgggtccgc gctgggggag gcgcgccacg acggcgccga catggctcct
      661 ttaaagctga gtattcgggc ccctcgtgcg ggccgcgcgc tttccgagcc cggggaagtc
      721 acgtggcttc acacgttcga ttgcttctgg agccctagcc ctgagggtgg accggaccag
      781 gaagaagaat caggaaggat aaaggactgc tgggacaacc aagaggttcc tgcactctct
      841 acatgtagca atgccaatat ctttcgaagg ataaatgcca ttttggatga ttcactggac
      901 ttcagtaaag tctgcacaac acctataaat cgaggaattc atgatcagtt gccagacttc
      961 caggactctg aagaagcaat tacaagcagg atgcttttcc ccacctctgc gcaagaatct
     1021 ccccgcggcc tcccagatgc aaacggtttg tgccttggcc tgcagtcact cagtctgact
     1081 ggctgggacc gaccctggag cacccaggac tcagactcct cagcccagag caacacacag
     1141 tcagtattaa gcatgctcca aaatccactg ggaaatgtct taggaaaaac ccccttgagc
     1201 ttcctgtctc tggatcccct tgggtctgac ttggacaagt tcccagcgcc ctcagttaga
     1261 ggatctcgcc tggacacccg gcctatcctg gactcccgtt ctagcagccc ctctgactca
     1321 gacacgagtg gcttcagctc tggatcagat catctctcag atttgatttc aagccttcgc
     1381 atttcccctc ctctgccctt tctttctatg acgggaaatg gtcccagaga ccctctaaag
     1441 atgggagttg ggtctcgaat ggaccaagag caagctgctc ttgctgcagt tgctccctct
     1501 ccaaccagtg ctccaaagag atggccagga acttctgtgt ggccatcttg ggaccttctc
     1561 ggagctccta aagacccatt cagcatagag agagaggcta gactccacag gcaggccgca
     1621 gctgtgaatg aagctacatg tacctggagt ggccagcttc ctccccggaa ctacaagaac
     1681 cccatctact catgcaaggt gttcctagga ggtgttcctt gggacattac agaagctgga
     1741 ttggttaaca ccttccgtgt ttttggctct ctgagtgtgg agtggcctgg gtatgtgtat
     1801 ttggtgtttg aactagagaa gtccgtccgg gccttgcttc aggcttgttc tcatgaccca
     1861 ctgagcccag atggcctaag tgaatattat ttcaagatgt ccagccgaag gatgcgctgc
     1921 aaagaagtac aggtaatccc ttgggtcttg gctgacagca actttgtctg gagcccatct
     1981 cagaggctgg atcccagcag gacggtgttt gttggtgcct tgcacgggat gctcaatgct
     2041 gaggctctgg ctgccatctt gaatgaccta tttggtggag tggtgtatgc tgggattgac
     2101 acagataagc acaagtaccc cattgggtct ggtcgtgtga ctttcaataa ccaacgtagt
     2161 tacctgaaag cagtcactgc tgcttttgtg gagatcaaaa ccaccaagtt taccaagaag
     2221 gttcagatcg acccctatct agaagattct ctgtgtctta tctgcagttc acaacctggt
     2281 cctttcttct gccgagatca ggtctgcttc aagtactttt gccgaagctg ctggcactgg
     2341 cgacacagca tggaaggcct acgccaccac agcccgctaa tgaggaacca gaagaactaa
     2401 aattccagct agagaagctg gcctggccca gggcctgtgg cgccaaaggc tggcaagtca
     2461 ggcagcagcc tgttccctgc acgggcgcct aggagctagc tttctgcaga caagggagaa
     2521 ttgtactcac ctttgtactt gctgagtctg tctttgtttc tgcactaatt aatgcacaat
     2581 gagttttgtc aggttttgtc ttcagcgggg tgtgccagag caggggcctc aggctcaccc
     2641 tcaagcaatt gtagttttcc cagattctag ttcctcattt tgcaaatgaa aacaacaaaa
     2701 aaaactgtgt ctagaacgcg ttgacacaga tgcctacact tgggtttatt tattaaagcg
     2761 cttcttacat tccttgcaat actgatggtg gtgatgcgca ggtctcattg gtccattctt
     2821 gcagttgcca tacagtgcct ttccatttat ttaaccccca cctgaacggc ataaattgag
     2881 tgttcagctg gtgtttttta ctgtaacaaa caaaggagac tttgctcttc atttaaacca
     2941 aatcatattt catagtttac gctcgagggt ttttactggt tcctttttac actccttaaa
     3001 acagttttta agtcgtttgg aacaatagat ttttttttct tttttggcag cttttaacat
     3061 tatagcaaat ttgtgtctgg gggactgctg gtcacagttg caaatcaaag catttgtaac
     3121 caagagaaaa attattttat ttaaaactgg atgggaggaa aaattaggtc tgagcagctg
     3181 ctgtatatag ttttaaatgg tttgtcgcac cttatgttgc acttacgttg ggggagggtt
     3241 gatagaagtt tttaatcaca gtcacaggac tttttctttt gtaactgagc ttaaaaatta
     3301 aaaaaaaaaa aagggctgct ttttggtggg ggcggatgaa ggctcacagg agccctttct
     3361 cttagagggg caagtaccct tccttacaac ttttatttga agaatgtatg aatcaacagt
     3421 tattgttgac aaaaatgtta ctggaattga aaacttgact ctttttttaa aaatttagtt
     3481 actacttgcc cctcttaggg aagctgtgtg ccaaagaacc agtgtcgccc ccctgctgag
     3541 ctgacgttgc attgtcgcat atcccagcta ctctgtgggc tcgtgaagct gtgtgtgaag
     3601 tctctacctc attgttgtac atgcaggcaa gactgcactc tgtacagatt gtggagtaag
     3661 ctgtggtgta ctttttttgg cacataataa acacgttgca gcaga
//
LOCUS       NM_022938               3097 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 7 (Htr7), transcript
            variant 2, mRNA.
ACCESSION   NM_022938
VERSION     NM_022938.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Korlatowicz,A., Pabian,P., Solich,J., Kolasa,M., Latocha,K.,
            Dziedzicka-Wasylewska,M. and Faron-Gorecka,A.
  TITLE     Habenula as a Possible Target for Treatment-Resistant Depression
            Phenotype in Wistar Kyoto Rats
  JOURNAL   Mol Neurobiol 60 (2), 643-654 (2023)
   PUBMED   36344870
  REMARK    GeneRIF: Habenula as a Possible Target for Treatment-Resistant
            Depression Phenotype in Wistar Kyoto Rats.
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Slawinska,U., Majczynski,H., Kwasniewska,A., Miazga,K., Cabaj,A.M.,
            Bekisz,M., Jordan,L.M. and Zawadzka,M.
  TITLE     Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar
            Spinal Blockade of 5-HT7 Receptors
  JOURNAL   Int J Mol Sci 22 (11), 6007 (2021)
   PUBMED   34199392
  REMARK    GeneRIF: Unusual Quadrupedal Locomotion in Rat during Recovery from
            Lumbar Spinal Blockade of 5-HT7 Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Cinar,I., Halici,Z., Dincer,B., Sirin,B. and Cadirci,E.
  TITLE     The role of 5-HT7 receptors on isoproterenol-induced myocardial
            infarction in rats with high-fat diet exacerbated coronary
            endothelial dysfunction
  JOURNAL   Hum Exp Toxicol 39 (8), 1005-1018 (2020)
   PUBMED   32329363
  REMARK    GeneRIF: The role of 5-HT7 receptors on isoproterenol-induced
            myocardial infarction in rats with high-fat diet exacerbated
            coronary endothelial dysfunction.
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Hernandez-Abreu,O.I., Garcia-Pedraza,J.A., Rivera-Mancilla,E.,
            Villanueva-Castillo,B., Moran,A., Garcia-Domingo,M.,
            Manrique-Maldonado,G., Altamirano-Espinoza,A.H. and Villalon,C.M.
  TITLE     Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7
            receptors inhibiting the tachycardic sympathetic drive in pithed
            rats
  JOURNAL   Clin Exp Pharmacol Physiol 47 (3), 403-411 (2020)
   PUBMED   31846086
  REMARK    GeneRIF: Blockade of 5-HT2 receptors with sarpogrelate uncovers
            5-HT7 receptors inhibiting the tachycardic sympathetic drive in
            pithed rats.
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Seitz,B.M., Demireva,E.Y., Xie,H., Fink,G.D., Krieger-Burke,T.,
            Burke,W.M. and Watts,S.W.
  TITLE     5-HT does not lower blood pressure in the 5-HT7 knockout rat
  JOURNAL   Physiol Genomics 51 (7), 302-310 (2019)
   PUBMED   31125292
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Ruat,M., Traiffort,E., Leurs,R., Tardivel-Lacombe,J., Diaz,J.,
            Arrang,J.M. and Schwartz,J.C.
  TITLE     Molecular cloning, characterization, and localization of a
            high-affinity serotonin receptor (5-HT7) activating cAMP formation
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8547-8551 (1993)
   PUBMED   8397408
REFERENCE   8  (bases 1 to 3097)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
REFERENCE   9  (bases 1 to 3097)
  AUTHORS   Shen,Y., Monsma,F.J. Jr., Metcalf,M.A., Jose,P.A., Hamblin,M.W. and
            Sibley,D.R.
  TITLE     Molecular cloning and expression of a 5-hydroxytryptamine7
            serotonin receptor subtype
  JOURNAL   J Biol Chem 268 (24), 18200-18204 (1993)
   PUBMED   8394362
REFERENCE   10 (bases 1 to 3097)
  AUTHORS   Meyerhof,W., Obermuller,F., Fehr,S. and Richter,D.
  TITLE     A novel rat serotonin receptor: primary structure, pharmacology,
            and expression pattern in distinct brain regions
  JOURNAL   DNA Cell Biol 12 (5), 401-409 (1993)
   PUBMED   8517926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_022938.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22558.1, U68489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               JAXUCZ010000001.1  243172386-243173048 c
            664-1424            JAXUCZ010000001.1  243059689-243060449 c
            1425-3097           JAXUCZ010000001.1  243049064-243050736 c
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..3097
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="5-hydroxytryptamine receptor 7"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
     exon            1..663
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    41..43
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="upstream in-frame stop codon"
     CDS             116..1423
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serotonin receptor 7; GPRFO; 5-HT-7; 5-HT-X; 5-HT7; high
                     affinity serotonin receptor (5HT7); 5-hydroxytryptamine
                     (serotonin) receptor 7, adenylate cyclase-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 7 isoform 2"
                     /protein_id="NP_075227.1"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
                     /translation="MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSW
                     MPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGN
                     CLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV
                     FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL
                     PPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH
                     KFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGI
                     IVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNR
                     DLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVL"
     misc_feature    128..130
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2); glycosylation site"
     misc_feature    320..322
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2); glycosylation site"
     misc_feature    374..448
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    413..1309
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_5-HT7; cd15329"
                     /db_xref="CDD:320452"
     misc_feature    413..1309
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_5-HT7; cd15329"
                     /db_xref="CDD:320452"
     misc_feature    470..550
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320452"
     misc_feature    470..550
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320452"
     misc_feature    479..544
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    581..658
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    587..679
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320452"
     misc_feature    587..679
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320452"
     misc_feature    order(596..601,608..613,620..625,815..817,851..853,
                     863..865,1142..1144,1151..1156,1172..1174,1211..1213,
                     1220..1225,1232..1234,1244..1246)
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320452"
     misc_feature    order(596..601,608..613,620..625,815..817,851..853,
                     863..865,1142..1144,1151..1156,1172..1174,1211..1213,
                     1220..1225,1232..1234,1244..1246)
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320452"
     misc_feature    713..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320452"
     misc_feature    713..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320452"
     misc_feature    719..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    830..919
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320452"
     misc_feature    830..919
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320452"
     misc_feature    836..904
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    1082..1174
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320452"
     misc_feature    1082..1174
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320452"
     misc_feature    1103..1180
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    1211..1288
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320452"
     misc_feature    1211..1288
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320452"
     misc_feature    1214..1285
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     exon            664..1424
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3097
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccccatg gctgggccgc gcggagccga gcgggcaagg tgaatccagc cccggggccg
       61 gctgccggag cgcttggcgg ggtcgccggc tccatgggca gcggcgctcg gcacgatgat
      121 ggacgttaac agcagcggcc gccccgacct ctacggccat ctccgttcac tcatcctgcc
      181 ggaggtgggg cgcgggctgc aggacctgag ccccgacggt ggcgcccacc ctgtggtgag
      241 ctcctggatg ccgcacctgc tgagtggctt cctagaggtg acggctagcc cggcgcccac
      301 ctgggacgcg ccaccggaca atgtctcagg ctgcggggag cagatcaact atggcagagt
      361 ggagaaagtt gtgatcggct ccatcctgac gctcatcacg ctgctgacga tcgcaggcaa
      421 ctgcctggtg gtgatctcgg tgtgcttcgt caagaagctc cgccagccct ccaactacct
      481 gattgtgtcc ctggcgctgg ctgacctctc ggtggccgtg gcggtcatgc ctttcgttag
      541 tgtcaccgac ctcatcgggg gcaagtggat cttcggccac ttcttctgca acgtcttcat
      601 cgccatggac gtcatgtgct gcacggcctc gatcatgacc ctgtgcgtga tcagcatcga
      661 caggtacctt gggatcacga gacccctcac gtacccggtg aggcaaaatg ggaaatgtat
      721 ggccaaaatg attctgtcgg tctggctgct ctctgcctcc atcaccttac ctcctctctt
      781 cggatgggct cagaatgtga acgatgacaa agtgtgcttg atcagccagg attttggcta
      841 cacgatctac tccactgcgg tggcgtttta tatccccatg tcggtcatgc tgttcatgta
      901 ctatcagatt tacaaggccg ccaggaagag tgcagccaaa cacaagttcc caggcttccc
      961 acgcgtgcag ccggagagtg tcatctccct gaatggtgtg gtgaagctcc agaaggaggt
     1021 ggaagagtgt gcgaaccttt cgagactgct caaacacgaa aggaaaaaca tctccatctt
     1081 caagcgggaa cagaaagcag ccactacctt ggggatcatc gtgggagcct tcactgtgtg
     1141 ctggctgccg tttttcctct tgtccacagc ccgccccttt atctgtggca cctcctgtag
     1201 ctgcattcct ctgtgggtgg agaggacatg tctgtggctg ggctatgcaa actctctcat
     1261 taatcctttt atatatgcct tcttcaaccg ggacctgagg accacctatc gtagcctact
     1321 ccagtgccag taccggaata tcaaccggaa gctctctgct gcaggcatgc atgaagccct
     1381 gaaacttgct gagaggcccg agagatccga gtttgtgctg taagacaaaa ctctgaccac
     1441 tgtgggaaaa agggtcatga tacatgatcc agagtggaac cctggatgaa ttcatgcaga
     1501 acaggtggac acaacacaac gaaatcattg gctgagactg cacaatggaa catggcttct
     1561 gtcttcttgg catggcttga aatgtcacga ggggtgatct gttgtacaaa gtgtatcatg
     1621 gggagatggc aacctctccc ttttttcctg tggatcagtg atattgtgtt taaatgaaaa
     1681 tagtgctcag tgtcagacag ccagtcatct ctgcagtaag cacactacag agctgggttt
     1741 cgggagggga gggaagcagt ttctggtgct ttccacaagt ccacatccac aagagtgggg
     1801 ggaaatccta acgcacaatt cccatgcttc cagtctaggc tttgtggtaa ctcttcagga
     1861 accattcatg agacagagta cattttgtgg tatgacagaa gggtgtcttt tcaagcaagc
     1921 tacagtaagc attgtgctga acgtgttgca tgtccgtgtt agaaaacaga aacccagtca
     1981 tcagctaatt caagcaattc cccagagcag tgtttgttca aagcttctgt taaatattgt
     2041 ggctttcctg cagggtcctt gtgactttcc accagtgtgt gtccactgtc aaatccttta
     2101 tcattatggt gtaactcagg aacagatctc aggttggaga gaggcagaaa acctgaatca
     2161 agcttttcct tgcactcaca cttctgaagg ctcctgagag aggacggtaa ctggagatga
     2221 gtgagtgcca cctcaccgca ttgtatatta acatgattct cggcatgttg ttcactccca
     2281 tcttccacaa gggtgcaagg agcccacagg gctggtccat gactgtgtgt tatgaggaga
     2341 gagtgtgaca atagcaaatc catgaatagt tgcggttgtt tctggagaca gcgtaaacat
     2401 ggtcacccaa ctggactgtt tgaatcgtgt gagctagcgg ccacttgaac ccccattgtt
     2461 aatactctag aacaccgttc tgtttcatgt agagaatttg tttctgtgtt ctctgtatct
     2521 taaatcaaat gtgtgcctga tgaattctgt cctctaaccc cctcccacca ataaaaatgg
     2581 tcaatgttaa ggacaggtaa ggaagcagaa agggttcctt tgtggatagt atcctttaaa
     2641 tgttgctatg tagtagtctg ggtgaaggag atggaaagcc acagttcaga agagtacccg
     2701 tgtctataag ggggacatga atgaaaacct ttatttgaaa aaagggaact gaaaaagaat
     2761 attattttcc tacaattaag aaggctgtcc tctcacagaa taaaatagag ttccaaagtg
     2821 tattatgaac ttcttccaga tgtcactgat gtctattatg aaagcaggga agggcccctt
     2881 tcctgtgaag gggaggcagg cactgtcctt tcagaatgtg tacaaattcc tgagctgcag
     2941 ttttgctaga ctgaccatat atacttatat tcctaattta aataacaatt atgtcagata
     3001 tgtgttgtta aatttgaaag tgttttatta cattacatcg aaataaaggt tatttgtagc
     3061 tgtaataaag caacttaagc aacgttttta ataaaaa
//
LOCUS       NM_001438395            4198 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus centlein (Cntln), transcript variant 2, mRNA.
ACCESSION   NM_001438395
VERSION     NM_001438395.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4198)
  AUTHORS   Fang,G., Zhang,D., Yin,H., Zheng,L., Bi,X. and Yuan,L.
  TITLE     Centlein mediates an interaction between C-Nap1 and Cep68 to
            maintain centrosome cohesion
  JOURNAL   J Cell Sci 127 (Pt 8), 1631-1639 (2014)
   PUBMED   24554434
REFERENCE   2  (bases 1 to 4198)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4198)
  AUTHORS   Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
            Nakanishi,H.
  TITLE     Identification and characterization of the novel centrosomal
            protein centlein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 958-962 (2008)
   PUBMED   18086554
  REMARK    GeneRIF: The molecular characterization of a novel protein, named
            centlein (centrosomal protein), is described. Centlein was a
            protein of 721 amino acids with a calculated molecular weight of
            82,717 and possessed coiled-coil domains.[Centlein]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.19560.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000005.1  104342081-104342607
            528-616             JAXUCZ010000005.1  104346801-104346889
            617-701             JAXUCZ010000005.1  104397789-104397873
            702-836             JAXUCZ010000005.1  104408527-104408661
            837-1016            JAXUCZ010000005.1  104409252-104409431
            1017-1150           JAXUCZ010000005.1  104425166-104425299
            1151-1313           JAXUCZ010000005.1  104427394-104427556
            1314-1508           JAXUCZ010000005.1  104437880-104438074
            1509-1634           JAXUCZ010000005.1  104457803-104457928
            1635-1756           JAXUCZ010000005.1  104465089-104465210
            1757-1876           JAXUCZ010000005.1  104466573-104466692
            1877-1977           JAXUCZ010000005.1  104518465-104518565
            1978-2069           JAXUCZ010000005.1  104523774-104523865
            2070-2602           JAXUCZ010000005.1  104527100-104527632
            2603-2777           JAXUCZ010000005.1  104548135-104548309
            2778-2853           JAXUCZ010000005.1  104552521-104552596
            2854-3077           JAXUCZ010000005.1  104552679-104552902
            3078-3269           JAXUCZ010000005.1  104581424-104581615
            3270-3367           JAXUCZ010000005.1  104585529-104585626
            3368-3494           JAXUCZ010000005.1  104587165-104587291
            3495-3632           JAXUCZ010000005.1  104588297-104588434
            3633-3818           JAXUCZ010000005.1  104588742-104588927
            3819-4198           JAXUCZ010000005.1  104592947-104593326
FEATURES             Location/Qualifiers
     source          1..4198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..4198
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="centlein"
                     /db_xref="GeneID:679640"
                     /db_xref="RGD:1308101"
     exon            1..527
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3863
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="isoform 2 is encoded by transcript variant 2;
                     centrosomal protein; centlein, centrosomal protein"
                     /codon_start=1
                     /product="centlein isoform 2"
                     /protein_id="NP_001425324.1"
                     /db_xref="GeneID:679640"
                     /db_xref="RGD:1308101"
                     /translation="MAARSPSSSPPSPLARRSSRRALRVGRGAEVHAVRSEASGLAST
                     AREVVADKSDLLWRGKEGSGGRRGSGRPGAALAPVLSAPVGSWWPGGLSSVEAKATRS
                     QLLEEELSSVKEELAQCQADKEFVWSLWKRLQATNPDLTQTVSLVVEREKQKSEAKDR
                     KVLEILQVKDAKIQELEQTEAVLNRELYDLVKLKTLVDEENAFLKKEFSDLQKKFKDK
                     SQEAKDAKECVQSKEEQNRLLIKNLEEENERVRARCTDLLNDLEKLRMQEAHWREEKH
                     SADAKVKVLEENLIEAKKEIESSQSRYNAVSLQLNSKQTELLQKDMDITLVRKELQEL
                     QNLYKQNSAHTAQQADLIQQLQVLNMDTQKVLRNQEDAHTAESITYQELYNELHICFE
                     TTKSNEAMLQQRVANLQHQLFQKEQENVKLKEKLQESQGTLGLSPHESDSNHSAKEPP
                     VKRSRSLSPKSCFMDSEELRKLKKAERKIQNLEKTLQLKSQENDELRDAHEKRKERLQ
                     MLHTNYKAVREQLKQWEEDSGMTETRKPKRADPQQLRREDSDAVWNELAYFKRENQEL
                     MVQKMNLQDELDELKIYMTIDKTTIQELNRCMAEKREEQLFRHHEDAGVKKSTPEKNE
                     KAISEQTLEKVIELENRLKSFEKNSRKLKEESKKLKKENDFLKSHLQHYQEDSESRGK
                     ELEKLLRVSSSVEQDKSELQTKVTALEREVTTLRRQVAKAKALRDENEEVVNPEEKEH
                     CPTDKAKSEMATTDVRAQHCDCKTTTTKVKFKAAKKKCSVGRHHTVLNHSVKVMSHVE
                     NLSKDGWEDMSEGSSDSETQTFQNLGTVIVETSQNIRPIENDGNQKETDQTEDSRAQQ
                     EVQTYSCEDLKAPQNTKKMTFQNKSGSLQKNLHSALPARVNREKCKTKPAQKSSSNTI
                     LLRERIVSLQQQNSLLQNARKAAESSAKEFKEANEKLLHQQQISDHRFQTSRQTIKKL
                     TLDLAELRKEKEDLLKKVESSSDITSLAEEVSRIMAPQIQVTTLGPSRSTDLEIKQLQ
                     CKLKNATNELTKQSSSVKSLKLELLAKDDHMKAMQEKMSRMERDITMKRHLIEDLKFR
                     QKINSESNESFNEMLGTLEKKVKTLTEECSNKKVSVDSLKQRLSVAVKEKSQYEQMYQ
                     KSKEELEKKDLKMNLLISKLNDTETAMAQIKSAASEQLQGLALQSEQVLEGTQKKLLL
                     ANEKIEEFTVFVQGTSRLWKRWKGHLL"
     misc_feature    <480..>2348
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <480..>2348
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1578..3803
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1578..3803
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            528..616
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            617..701
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            702..836
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1016
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1150
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1313
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1508
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1634
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1756
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1876
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1977
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2069
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2602
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2777
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2853
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3077
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3269
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3367
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3494
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3632
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3818
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..4198
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccgcgct cggagctcgg cccgcgggaa gcggactggg gcccgcgagc gccggacaag
       61 gcgggaaaag ctccgcgcat gcgtatgctg gcaggcccgg ctcctcagga tggggaaggg
      121 aaggtggagt tttcaagcgg gaacttgacc cgttaggcgc cgcggctatg gcggcgcgct
      181 cgccgtcgtc ctcaccgcct tcgcccctgg cgcggcggtc cagccgccgg gccctgcgcg
      241 tcgggcgtgg agccgaggtg cacgctgtgc gcagcgaggc ctcgggtctg gcgagcaccg
      301 cgagggaggt cgtcgcggat aaaagcgact tactctggag gggcaaagaa gggtcagggg
      361 gccggcgagg gtccgggcgg cccggggccg ctctcgctcc agtcctcagc gcgcctgtgg
      421 ggtcctggtg gccagggggc ctctcctcgg tggaggcgaa ggcaacgcga tcgcagctgc
      481 tggaggaaga gctgagcagc gtaaaggagg agctggccca gtgtcaggct gacaaagaat
      541 tcgtatggtc tctgtggaaa cgtcttcagg caacaaaccc agatctcact caaactgtca
      601 gtttggttgt ggaaagagaa aaacagaaat ctgaagccaa agacagaaaa gttctggaaa
      661 ttttacaagt caaagatgcg aaaatacaag aattggagca gactgaagca gtactaaacc
      721 gggagctata tgaccttgta aagctgaaga cgctggttga tgaagaaaat gctttcttga
      781 agaaagaatt cagtgattta cagaagaaat ttaaagataa aagccaagaa gctaaggacg
      841 ccaaggagtg tgtacagagt aaagaagagc aaaacagatt gcttataaaa aacctggagg
      901 aggaaaacga gagggtccgt gcacgctgca ctgacctgct aaatgacctg gagaaactga
      961 ggatgcagga ggcacactgg agggaagaaa agcacagtgc ggatgcgaaa gtaaaggtcc
     1021 ttgaagaaaa tttgattgaa gcaaagaagg aaattgagtc gtcacagagt agatataatg
     1081 ctgtgtcact gcagctgaac agcaaacaga ctgaacttct ccaaaaagat atggacatca
     1141 cactcgtcag gaaggaactg caggagctgc agaatctgta caagcagaac agtgcacaca
     1201 cagcacagca agcagacctg atccagcagc tccaggttct caatatggat acgcagaaag
     1261 tactgaggaa ccaggaagat gctcacacag ctgaaagtat aacataccag gaactttata
     1321 atgaattaca tatttgtttt gaaactacaa aatcaaatga agctatgctc cagcaaagag
     1381 ttgctaatct tcagcatcaa ctgtttcaaa aagaacagga aaatgtaaaa ttaaaagaaa
     1441 aacttcagga atcacaagga acactgggtt tatcaccgca cgagagtgat tcaaaccact
     1501 cagcaaagga gccacctgtg aaacgctcaa ggtctttgtc cccaaagagc tgtttcatgg
     1561 actccgagga gctaaggaag cttaaaaagg ctgaaagaaa gattcaaaac ttagagaaga
     1621 cactacagct aaagagccaa gaaaatgatg agctaagaga tgcccatgaa aaacgcaagg
     1681 aaaggctaca gatgttacac accaactaca aagcagtaag agagcaatta aaacagtggg
     1741 aggaagacag tggcatgact gaaaccagaa aaccgaagcg agcagatcct caacagcttc
     1801 gacgagaaga ttctgatgct gtgtggaatg aactggcata tttcaaaaga gaaaaccagg
     1861 agttgatggt tcaaaagatg aatcttcaag atgaattgga tgagcttaaa atatatatga
     1921 ctattgataa aacaacaata caggaattga acagatgcat ggcagagaaa agagaagaac
     1981 aactctttag acaccatgaa gatgctgggg tcaagaagag tactccagag aagaatgaga
     2041 aagcaatatc ggagcagaca ttagagaagg tcattgagtt ggaaaatcgg ctaaaatctt
     2101 ttgagaaaaa ctcaagaaaa ttaaaagaag agagtaagaa attaaagaaa gaaaatgatt
     2161 tcctgaaatc ccacttacaa cactatcaag aagactcgga gagcagagga aaggagctag
     2221 agaaactact gagagtgagc agcagtgtag aacaggacaa aagtgagctt caaacaaaag
     2281 tcactgctct ggagagggag gtcactacgc tgaggagaca agtggcaaaa gctaaggctt
     2341 tgagagatga aaacgaagag gtggtgaatc cagaggaaaa ggaacactgc ccaacagaca
     2401 aagctaaatc tgagatggcc accacagatg tgagagccca gcactgtgac tgcaagacaa
     2461 ccactaccaa ggtgaaattt aaagctgcca agaaaaagtg ctctgtgggt cgccaccaca
     2521 ctgttctcaa tcactccgtc aaggttatga gccatgtgga gaacctcagc aaggatggct
     2581 gggaggacat gagtgaaggc agcagtgatt ctgaaacaca aacctttcaa aatttgggaa
     2641 cagttattgt ggaaacatcc cagaatataa ggcctataga aaatgatgga aaccagaagg
     2701 aaactgacca aacagaagac agccgtgctc aacaagaagt gcagacatac tcctgtgagg
     2761 acctcaaggc cccacagaat acgaagaaaa tgacttttca aaacaagagt ggaagtctac
     2821 agaagaactt acacagtgcc cttcctgcca gagttaacag agaaaagtgc aaaactaaac
     2881 ctgcccagaa atccagtagc aacactattt tattacgaga acggattgta tccttgcagc
     2941 aacaaaacag tttgcttcag aatgccagga aagcagcaga gtcgtctgct aaagaattta
     3001 aagaagcaaa tgaaaaactc ctccatcaac agcagatatc tgatcaccga ttccagacca
     3061 gcaggcagac aataaagaag ctaactcttg atttagctga acttcgaaaa gagaaagaag
     3121 atttgttgaa gaaagtggag tcttcatctg acatcacaag cttggcagaa gaagtttcca
     3181 gaataatggc cccacagata caagttacca cactgggtcc ttcaaggagc acggatttgg
     3241 aaataaagca attgcagtgt aaactaaaga atgcaactaa cgaactcact aagcagtcct
     3301 cgagtgtgaa gtcgctgaag ctggaacttc tggcgaagga tgaccacatg aaggcgatgc
     3361 aggagaagat gtctcgaatg gagagagata taaccatgaa aagacacctg attgaggact
     3421 tgaaatttcg acagaaaata aattcagaaa gtaatgagag ttttaatgaa atgttaggaa
     3481 ctcttgaaaa aaaggtaaag acattaactg aagaatgttc caacaagaag gtatcagttg
     3541 attcactaaa gcaaagactt agcgttgctg tgaaagagaa atcacagtat gaacagatgt
     3601 atcagaaaag taaagaggag ttagaaaaaa aggatctcaa gatgaatctc ctgatatcaa
     3661 aactaaatga cacggagaca gccatggctc agatcaagag cgcagcgtcg gagcagctcc
     3721 aaggcttggc gttgcagagt gagcaggtcc tggaaggcac gcagaagaaa ctgctgctgg
     3781 ccaatgaaaa gatcgaggag ttcactgtct ttgtgcaggg cacaagcaga ctatggaaga
     3841 ggtggaaggg ccatctgctc tagatctact cttgaatatg gaatttggcc ctggggtgaa
     3901 atcaagtgct ttgagcatct gggctggata tatgtggcag agctgaggct ttgaattctc
     3961 ctagtaactg gataaaacac actggggaaa tttctagaag tatttgctca atttgagtca
     4021 gccttgatat tatatatagg tttgttaatg tgcatgcatg tgagagtcat atgccagaca
     4081 ccattttctc aaaaattttt gttgttctta actataaaat acaagctagc taaacaacag
     4141 catttagctg gaacgtgtgc atggtttcct tatcaataaa tgtttttgtt tggtaaaa
//
LOCUS       NM_001438410            1085 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 9, mRNA.
ACCESSION   NM_001438410
VERSION     NM_001438410.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1085)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1085)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1085)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.864665.1,
                                           SRR22399492.638313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000001.1  213563363-213563416
            55-237              JAXUCZ010000001.1  213563668-213563850
            238-384             JAXUCZ010000001.1  213564268-213564414
            385-575             JAXUCZ010000001.1  213570794-213570984
            576-1085            JAXUCZ010000001.1  213571525-213572034
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1085
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..54
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..237
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..384
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    372..374
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="upstream in-frame stop codon"
     exon            385..575
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..701
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 9 is encoded by transcript variant 9; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 9"
                     /protein_id="NP_001425339.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="METRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRY
                     GRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ"
     misc_feature    <396..698
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    <396..698
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            576..1085
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactggag agaggaggca ggcccgagtc aggggcctcg agaacgggct tgggcccaga
       61 gtatgttcca gatcccagag tttgagccga gtgagcagga agacgctagt actacagata
      121 ggggcctggg ccctagcctc actgaggacc agccaggtcc ctacctggcc ccaggtctcc
      181 tggggagcat cgttcagcag cagccgggac aggcagccaa taacagtcat catggagatg
      241 gagcaggcag gtgaccctaa gtgacaagcc agagccgtgt gaagttggaa agaggaagac
      301 ggagaggcgt tggaagacac tggttatact ttccacttcc catcgctgac cccgtaacag
      361 ccacagaaac ctgagctcaa ccaggcgctg ggactatgga gacccggagt cgccacagtt
      421 cgtacccagc ggggactgag gaagatgaag ggatggagga ggagcttagc ccttttcgag
      481 gacgctcgcg ctcggctccc cccaatctct gggcagcgca gcgctatggc cgtgagctcc
      541 gaagaatgag cgatgaattt gagggttcct tcaagggact tcctcgccca aagagcgcag
      601 gcactgcaac acagatgcga caaagcgcca gttggacgcg cattatccag tcctggtggg
      661 atcgaaattt ggggaaagga ggctccactc cctcccagtg atctgctcca cattcccgga
      721 attctacccg ctcccatcgc ccgccatatt gggtgtgggc ggaagtcttt cgaggcctta
      781 ggaaaaaagg atcgctgtgt ccctttaaca gggagaagag ctgacgtaca gcgttgagtt
      841 ccttccggtg cgtgcaatag ccatggaggg gtggcccttg ctttggagtt ttcaaagttt
      901 tccacacacc ctacccccta cgcctccgga agtggctatg ttccctctcc gttactggac
      961 agccctcagg cgcctgtgct aagttgcgag tcctggtaaa ccgagactgg gtgctgtcct
     1021 atcatcctag ctggaggccc caggtcggga gaaacgtgct ttataataaa gcccgcgcat
     1081 gtgtc
//
LOCUS       NM_001438360            2352 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7),
            transcript variant 1, mRNA.
ACCESSION   NM_001438360 XM_006230893
VERSION     NM_001438360.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2352)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2352)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2352)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2352)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2352)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2352)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2352)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2352)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2352)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230893.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071500.1, SRR22399481.722411.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  208444568-208444623
            57-148              JAXUCZ010000001.1  208450390-208450481
            149-371             JAXUCZ010000001.1  208451583-208451805
            372-462             JAXUCZ010000001.1  208452757-208452847
            463-676             JAXUCZ010000001.1  208453456-208453669
            677-881             JAXUCZ010000001.1  208455552-208455756
            882-1013            JAXUCZ010000001.1  208457746-208457877
            1014-2352           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2352
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..56
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            57..148
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1478
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_001425289.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     misc_feature    168..230
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    327..1475
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    327..1475
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    345..407
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    492..554
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    579..641
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    759..821
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    846..908
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    966..1028
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1041..1103
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1308..1370
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     exon            149..371
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            372..462
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            463..676
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            677..881
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1013
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..2352
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttag ggcgctgctg gagctcgtga atcaaccgcc cggatcccgc acgcagatcc
       61 tgatggcttc aaagtcccag cacaacgctt ccaaagccaa gaatcacaac gtcaaggctg
      121 aatctcaagg acaatggggc cgtgcctggg aagtggactg gttctccctg gtcagcgtca
      181 ttttcctgct gctcttcgca ccgttcattg tgtactactt catcatggca tgtgaccagt
      241 acagctgctc gctgactgcc cccatattgg acgtagctac aggccgtgcg agtctggcag
      301 acatctgggc caagacaccg cctgtgacag ctaaggctgc ccaactgtat gccttgtggg
      361 tcagcttcca ggtgctgctt tactcctggc ttcctgactt ctgccacaga tttctgccag
      421 gttatgtggg aggcgtccaa gaaggtgcca taactccagc agggattgta aataagtatg
      481 aggtgaatgg gctgcaagcc tggctcatta cccacttcct ctggtttgtg aacgcttacc
      541 tcctatcctg gttctccccc accatcatct ttgacaactg gatcccgttg ctatggtgtg
      601 ccaacatcct gggctacgct gtgtccacct ttgcaatgat caaggggtac ctgttcccca
      661 ccagcgccga agactgcaaa ttcacaggca atttcttcta caactacatg atggggattg
      721 agttcaaccc ccgcatcgga aagtggtttg acttcaagct gttcttcaat gggcgcccgg
      781 ggattgtggc ctggactctt atcaacctgt cctttgctgc caagcagcag gagctttatg
      841 gccatgtgac caactccatg attttggtca atgtcttaca ggccatctat gtgttagact
      901 tcttctggaa cgaaacctgg tacctgaaga ccattgacat ctgccatgac cactttggat
      961 ggtacctggg ctggggagat tgcgtgtggc tgccctacct ctacacactg cagggcctgt
     1021 acttggtgta ccaccctgta cagctctcca cccccaacgc cttgggcgtc ctgctgctcg
     1081 gcctggtggg ttactatatc ttccgaatga ccaaccatca gaaggacctg ttccgccgga
     1141 cagatggaca ctgcctcatc tggggcaaga aacccaaggc catcgagtgc tcctacacgt
     1201 cagccgacgg gctgaagcac cgcagcaagc tgttggtttc aggcttctgg ggtgtggccc
     1261 gccacttcaa ctataccgga gacctgatgg gcagcctcgc ctactgcctg gcttgtggcg
     1321 gcggccacct cctcccctac ttctacatca tctatatgac tatcctgctt acccaccgct
     1381 gcctccgtga tgagcaccgc tgtgccaaca agtatggccg tgactgggag cgctacgtag
     1441 ccgctgtgcc ctaccgcctg ctgcctggga tcttctgagg gccaccctgg caagcagaaa
     1501 gaggcgtcat tgaatgtgtg gagttgggtg catgggggcc agcgtccggc tttcccctgc
     1561 aggggcctcc ttggtttgct cttctggagg atggagagcc aggcgcccca cagtgtctgg
     1621 ctggtggcag ctagagctga gttcacactg atgccccagc agaatgactg gttctccctg
     1681 ttcagcatcc tgagggcaga ggaccttggc cctttcatgt ctgttggaag cccaccatct
     1741 atgttgtcta gatagcttag gcttaccagg tgtctcccag gattgggcca tcctggtaaa
     1801 ctggagacaa tgtaggatct aaagagtttg gcaatgtcac cttcactccc acctgcaatg
     1861 gtgggctgga cccctttttc tgtctgtagt gtgatcagca gagggttcag gggccattga
     1921 aggaggaagg ctctttgttt aggttcttta ctgtttttac ccgaggaatg ccaagcagcg
     1981 gactggaata tcccactctg cacatccctg gctgacttga taaagtctgt ctgacatatg
     2041 agatggggtt cccagaactc cccaagtacc ccagctagca gcttatccat ctcccctctt
     2101 ccggaaggtg cttcttgttt acccctgaga cttggctcag aggtgaacag acttggctct
     2161 gacaacccag aatgtatcac cagttagtgg cctcagccac accttcccca acaggagaac
     2221 cagcgttggg gaaggaatcc attctcatta gtgacactgc cccccaaaac tcagggttat
     2281 tttgtaaaac tagataggct catgttagcc ttgcaagcgg ttctttgtat taaatctgcc
     2341 ttgttaaatg ag
//
LOCUS       NM_001438359            1367 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus vascular endothelial growth factor B (Vegfb),
            transcript variant 2, mRNA.
ACCESSION   NM_001438359 XM_006230910
VERSION     NM_001438359.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Tu,S., Wang,X.Y., Zeng,L.X., Shen,Z.J. and Zhang,Z.H.
  TITLE     LncRNA TINCR improves cardiac hypertrophy by regulating the
            miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway
  JOURNAL   Lab Invest 102 (3), 253-262 (2022)
   PUBMED   34732848
  REMARK    GeneRIF: LncRNA TINCR improves cardiac hypertrophy by regulating
            the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Shang,R., Lal,N., Lee,C.S., Zhai,Y., Puri,K., Seira,O.,
            Boushel,R.C., Sultan,I., Rasanen,M., Alitalo,K., Hussein,B. and
            Rodrigues,B.
  TITLE     Cardiac-specific VEGFB overexpression reduces lipoprotein lipase
            activity and improves insulin action in rat heart
  JOURNAL   Am J Physiol Endocrinol Metab 321 (6), E753-E765 (2021)
   PUBMED   34747201
  REMARK    GeneRIF: Cardiac-specific VEGFB overexpression reduces lipoprotein
            lipase activity and improves insulin action in rat heart.
REFERENCE   3  (bases 1 to 1367)
  AUTHORS   Lal,N., Chiu,A.P., Wang,F., Zhang,D., Jia,J., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     Loss of VEGFB and its signaling in the diabetic heart is associated
            with increased cell death signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (6), H1163-H1175 (2017)
   PUBMED   28314760
  REMARK    GeneRIF: Loss of VEGFB and its downstream signaling is an early
            event following hyperglycemia, is sustained with disease
            progression, and could explain diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 1367)
  AUTHORS   Monastero,R., Garcia-Serrano,S., Lago-Sampedro,A.,
            Rodriguez-Pacheco,F., Colomo,N., Morcillo,S., Martin-Nunez,G.M.,
            Gomez-Zumaquero,J.M., Garcia-Fuentes,E., Soriguer,F.,
            Rojo-Martinez,G. and Garcia-Escobar,E.
  TITLE     Methylation patterns of Vegfb promoter are associated with gene and
            protein expression levels: the effects of dietary fatty acids
  JOURNAL   Eur J Nutr 56 (2), 715-726 (2017)
   PUBMED   26707994
  REMARK    GeneRIF: Data suggest that dietary fatty acids create
            epigenetic/nutrigenomic changes in methylation levels of CpG island
            at Vegfb promoter and changes in Vegfb expression in white
            adipocytes in vivo and in vitro, with particular up-regulation of
            DNA methylation by linoleic acid; Vegfb promoter methylation levels
            are closely related to Vegfb gene expression in visceral and
            subcutaneous adipose tissue.
REFERENCE   5  (bases 1 to 1367)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   6  (bases 1 to 1367)
  AUTHORS   Nag,S., Eskandarian,M.R., Davis,J. and Eubanks,J.H.
  TITLE     Differential expression of vascular endothelial growth factor-A
            (VEGF-A) and VEGF-B after brain injury
  JOURNAL   J Neuropathol Exp Neurol 61 (9), 778-788 (2002)
   PUBMED   12230324
REFERENCE   7  (bases 1 to 1367)
  AUTHORS   Ikuta,T., Ariga,H. and Matsumoto,K.
  TITLE     Extracellular matrix tenascin-X in combination with vascular
            endothelial growth factor B enhances endothelial cell proliferation
  JOURNAL   Genes Cells 5 (11), 913-927 (2000)
   PUBMED   11122379
REFERENCE   8  (bases 1 to 1367)
  AUTHORS   Bellomo,D., Headrick,J.P., Silins,G.U., Paterson,C.A., Thomas,P.S.,
            Gartside,M., Mould,A., Cahill,M.M., Tonks,I.D., Grimmond,S.M.,
            Townson,S., Wells,C., Little,M., Cummings,M.C., Hayward,N.K. and
            Kay,G.F.
  TITLE     Mice lacking the vascular endothelial growth factor-B gene (Vegfb)
            have smaller hearts, dysfunctional coronary vasculature, and
            impaired recovery from cardiac ischemia
  JOURNAL   Circ Res 86 (2), E29-E35 (2000)
   PUBMED   10666423
REFERENCE   9  (bases 1 to 1367)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   10 (bases 1 to 1367)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230910.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.715914.1,
                                           SRR21887623.1257569.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000001.1  213606838-213607199 c
            363-405             JAXUCZ010000001.1  213606264-213606306 c
            406-602             JAXUCZ010000001.1  213605781-213605977 c
            603-676             JAXUCZ010000001.1  213605515-213605588 c
            677-712             JAXUCZ010000001.1  213605110-213605145 c
            713-948             JAXUCZ010000001.1  213604668-213604903 c
            949-1367            JAXUCZ010000001.1  213601570-213601988 c
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1367
                     /gene="Vegfb"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     exon            1..362
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..926
                     /gene="Vegfb"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; VRF; VEGF-B; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B isoform 2
                     precursor"
                     /protein_id="NP_001425288.1"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
                     /translation="MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYAR
                     ATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQIL
                     MIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDRVAIPHHRPQPRSVLSWDSAPGAS
                     SPADIIHPTPAPGPSAHAAPSAVSALIPGPAVAAADAAASSIAKGGA"
     sig_peptide     303..365
                     /gene="Vegfb"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35485.3)"
     mat_peptide     366..923
                     /gene="Vegfb"
                     /product="Vascular endothelial growth factor B.
                     /id=PRO_0000045174"
                     /note="propagated from UniProtKB/Swiss-Prot (O35485.3)"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    720..848
                     /gene="Vegfb"
                     /note="propagated from UniProtKB/Swiss-Prot (O35485.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            363..405
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            406..602
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            603..676
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            677..712
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            713..948
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1367
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgtccg ccagccccgg ccaggccccc tgccaccccc gccgtccccg ctgcccgccg
       61 tcccggccac caccaccaac acaggccgcc tgcctgtctc gttccttctg ccgccgctga
      121 ggcgctacgt tgcgctgcct gcgcccaggg ctcgggaggg ggccgcggag gagccgcccc
      181 ccgcgcccgg cccggggtcc ccacacccgg gcccgcgcca tgggactctg gctgccgccg
      241 ccccccgcgc cgccgggcta gggcaatgcg gtcgcccccg gcgctcggcc cccgcgggca
      301 ccatgagccc cctgctccgt cgcttgctgc ttgttgcgct gctgcagctg gcctgtaccc
      361 aggcccctgt gtcccagttt gatggcccca gccaccagaa gaaagtggtg tcatggatag
      421 atgtttatgc acgtgccaca tgccagccca gggaggtggt ggtacctctg agcatggaac
      481 tcatgggtaa tgtggtcaaa caactcgtgc ccagctgtgt gactgtgcag cgctgtggtg
      541 gctgctgtcc tgacgatggc ctggagtgtg tgcccattgg gcaacaccaa gtccgaatgc
      601 agatcctcat gatccagtac ccgagcagtc agctggggga gatgtccctg gaagaacaca
      661 gccaatgtga atgcagacca aaaagaaagg agagtgctgt gaagccagac agggttgcca
      721 taccccacca ccgtccccag ccccgctctg ttctgagctg ggactctgcc ccgggagcat
      781 cctccccagc tgacatcatc catcccactc cagccccagg accctctgcc cacgctgcac
      841 ccagcgccgt cagcgccctg atccccggac ctgccgttgc cgctgcagac gccgccgctt
      901 cctccattgc caagggcggg gcttagagct caacccagat acctgcaggt gccggaagct
      961 gcgaaggtga caagctgctt ttcggactcc acaggcctgt gtgcctcaca ggccttcttc
     1021 atagggagaa gagtggagca taggagaacc acctcagtct gggaggacat tgccccagga
     1081 cttggagctt ttagagagct ctcaccatct tttatctccc agagctgcct tctaacaatt
     1141 gtcaagagaa cctcatgcct caccttaggg gccagggtac tatctcagtt agccactctg
     1201 gtcaagtgaa catcttgctg gctgtctccc ctcactatga agaccccaaa cttctaccaa
     1261 tactaggact tgggttgtta tgataactgt gacacacaca cacacacaca cacacacaca
     1321 cacacacaca cacacacaca ctctgataaa agaaatggaa gacacta
//
LOCUS       NM_001438405            1184 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 3, mRNA.
ACCESSION   NM_001438405
VERSION     NM_001438405.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1184)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1184)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1184)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1184)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1184)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1184)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279911.1, SRR22399481.1966315.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JAXUCZ010000001.1  213562696-213563231
            537-719             JAXUCZ010000001.1  213563668-213563850
            720-910             JAXUCZ010000001.1  213570794-213570984
            911-1184            JAXUCZ010000001.1  213571761-213572034
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1184
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..536
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    341..343
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="upstream in-frame stop codon"
     CDS             419..1081
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 3 is encoded by transcript variant 3; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 3"
                     /protein_id="NP_001425334.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMF
                     QIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGA
                     GTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFE
                     GSFKGEELTYSVEFLPVRAIAMEGWPLLWSFQSFPHTLPPTPPEVAMFPLRYWTALRR
                     LC"
     misc_feature    419..835
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35147.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    545..>913
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    545..>913
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    617..619
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    755..757
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    803..805
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    812..814
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); methylation site"
     misc_feature    818..820
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); methylation site"
     misc_feature    821..823
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    827..829
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine, by PKA, PKB, PAK1, RPS6KA1, RPS6KB1
                     and PKC/PRKCQ. /evidence=ECO:0000250|UniProtKB:Q61337;
                     propagated from UniProtKB/Swiss-Prot (O35147.2);
                     phosphorylation site"
     misc_feature    860..904
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35147.2);
                     Region: BH3"
     misc_feature    884..886
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     exon            537..719
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..910
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1184
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcagg ccccgcgctc cggcctgcag cagagcccct tagagcccca cggctcgccc
       61 tcctgggctc ccctgtccat tcttccgcac ccgggcggcc atcctgccgg aaaggagctc
      121 ccgagatggc gcggggagtt gtccccaagg caggtagtgc aaggcttcca cgaccgggag
      181 gaggaaggag ctggtcttcc catcccggtc actcggtcca ggggaagcaa taaccatcgc
      241 aaagatcatt gcatccgacg gccaagcttc agtgaatgac tctataagta atcactaagc
      301 tgtttacaga gttttcacta gctcctcagg gaggtgtcat tagccccatt ttacaggagg
      361 aattcaggcc cagaagggct ggaggactta tcagccgaag caggcctcca ggatccaaat
      421 gggaacccca aagcagccct cgctggctcc tgcacacgcc ctaggcttga ggaagtccga
      481 tcccggaatc cggagcctgg ggagcgacgc gggaggaagg cggtggagac cagcagccca
      541 gagtatgttc cagatcccag agtttgagcc gagtgagcag gaagacgcta gtactacaga
      601 taggggcctg ggccctagcc tcactgagga ccagccaggt ccctacctgg ccccaggtct
      661 cctggggagc atcgttcagc agcagccggg acaggcagcc aataacagtc atcatggagg
      721 cgctgggact atggagaccc ggagtcgcca cagttcgtac ccagcgggga ctgaggaaga
      781 tgaagggatg gaggaggagc ttagcccttt tcgaggacgc tcgcgctcgg ctccccccaa
      841 tctctgggca gcgcagcgct atggccgtga gctccgaaga atgagcgatg aatttgaggg
      901 ttccttcaag ggagaagagc tgacgtacag cgttgagttc cttccggtgc gtgcaatagc
      961 catggagggg tggcccttgc tttggagttt tcaaagtttt ccacacaccc taccccctac
     1021 gcctccggaa gtggctatgt tccctctccg ttactggaca gccctcaggc gcctgtgcta
     1081 agttgcgagt cctggtaaac cgagactggg tgctgtccta tcatcctagc tggaggcccc
     1141 aggtcgggag aaacgtgctt tataataaag cccgcgcatg tgtc
//
LOCUS       NM_001438438            2081 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 7 member 9 (Slc7a9),
            transcript variant 2, mRNA.
ACCESSION   NM_001438438 XM_063266018
VERSION     NM_001438438.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Shigeta,Y., Kanai,Y., Chairoungdua,A., Ahmed,N., Sakamoto,S.,
            Matsuo,H., Kim,D.K., Fujimura,M., Anzai,N., Mizoguchi,K., Ueda,T.,
            Akakura,K., Ichikawa,T., Ito,H. and Endou,H.
  TITLE     A novel missense mutation of SLC7A9 frequent in Japanese cystinuria
            cases affecting the C-terminus of the transporter
  JOURNAL   Kidney Int 69 (7), 1198-1206 (2006)
   PUBMED   16609684
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Kwak,J.O., Kim,H.W., Jung,S.M., Song,J.H., Hong,S.B., Oh,K.J.,
            Ko,C.B. and Cha,S.H.
  TITLE     Co-localization and interaction of b0,+-type amino acid transporter
            1 (BAT1) with caveolin-1 in rat kidney
  JOURNAL   J Nephrol 18 (6), 681-689 (2005)
   PUBMED   16358225
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Feliubadalo,L., Font,M., Purroy,J., Rousaud,F., Estivill,X.,
            Nunes,V., Golomb,E., Centola,M., Aksentijevich,I., Kreiss,Y.,
            Goldman,B., Pras,M., Kastner,D.L., Pras,E., Gasparini,P.,
            Bisceglia,L., Beccia,E., Gallucci,M., de Sanctis,L., Ponzone,A.,
            Rizzoni,G.F., Zelante,L., Bassi,M.T., George,A.L. Jr., Manzoni,M.,
            De Grandi,A., Riboni,M., Endsley,J.K., Ballabio,A., Borsani,G.,
            Reig,N., Fernandez,E., Estevez,R., Pineda,M., Torrents,D.,
            Camps,M., Lloberas,J., Zorzano,A. and Palacin,M.
  CONSRTM   International Cystinuria Consortium
  TITLE     Non-type I cystinuria caused by mutations in SLC7A9, encoding a
            subunit (bo,+AT) of rBAT
  JOURNAL   Nat Genet 23 (1), 52-57 (1999)
   PUBMED   10471498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_063266018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1022.1,
                                           SRR26643288.2115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               JAXUCZ010000001.1  97246439-97246841
            404-486             JAXUCZ010000001.1  97247113-97247195
            487-598             JAXUCZ010000001.1  97247552-97247663
            599-746             JAXUCZ010000001.1  97249960-97250107
            747-989             JAXUCZ010000001.1  97250898-97251140
            990-1115            JAXUCZ010000001.1  97251592-97251717
            1116-1215           JAXUCZ010000001.1  97252103-97252202
            1216-1260           JAXUCZ010000001.1  97253443-97253487
            1261-1384           JAXUCZ010000001.1  97253983-97254106
            1385-1488           JAXUCZ010000001.1  97255053-97255156
            1489-1585           JAXUCZ010000001.1  97263488-97263584
            1586-1735           JAXUCZ010000001.1  97264466-97264615
            1736-1910           JAXUCZ010000001.1  97267191-97267365
            1911-2081           JAXUCZ010000001.1  97269374-97269544
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2081
                     /gene="Slc7a9"
                     /note="solute carrier family 7 member 9"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
     exon            1..403
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            404..486
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            487..598
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    503..505
                     /gene="Slc7a9"
                     /note="upstream in-frame stop codon"
     CDS             512..1975
                     /gene="Slc7a9"
                     /note="b(0,+)AT; solute carrier family 7 (amino acid
                     transporter light chain, bo,+ system), member 9;
                     glycoprotein-associated amino acid transporter b0,+AT1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 9; solute carrier family 7
                     (glycoprotein-associated amino acid transporter light
                     chain, bo,+ system), member 9"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_001425367.1"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
                     /translation="MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAIL
                     LITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSV
                     GSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIF
                     YFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE"
     misc_feature    512..580
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    548..1963
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    548..1963
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    563..565
                     /gene="Slc7a9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P82252.1); phosphorylation site"
     misc_feature    605..676
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    698..763
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    842..922
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    953..1018
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1019..1090
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1163..1225
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1265..1333
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1418..1486
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1565..1621
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1622..1684
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1742..1804
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1814..1861
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     exon            599..746
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            747..989
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1115
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1215
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1260
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1384
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1488
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1585
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1735
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1910
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2081
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagcc cggggagata gtaaagggct ggttccaaag tttattgctg cgattcctca
       61 gttgatgagc ggtttccatt gctgctctga agagatttct cctcacagga agtagccgat
      121 ctggaggaat ccgttttact gcagaaatga tctagataaa caaaaccaaa atgggggaag
      181 ctggacttgt ctgaccccct tattttttgt ctggtggtgt ctatcaaggc tttgttgctt
      241 agaaggaaga aaaaggggga gatgggtgtt taataattac ctctgttgac ctctgtacct
      301 tctggcttcc tccacgccta ggcacaagac atggcccttc ctggggcctg gccctgagtt
      361 gcgggctggg tggtggtcag caaggcaagc atcatcggca aaggttggct tgacttgctg
      421 aatagcccag gctggccctg aatttatcat ttttctacct caactacctc agtgctggga
      481 gttcagccct tggaactcac agtgagcaag gatggaggag acaagcccga ggagacggag
      541 agaggatgag aagtccgtcc acagtacaga gcccaagacc acaagtctcc agaaagaggt
      601 gggtcttctc agtggtatct gtatcattgt gggcaccatc atcggctccg ggatcttcat
      661 ctcccccaag tctgtgctgg ccaacacaga atccgtgggg ccctgtctca tcatatgggc
      721 agcctgtgga gtcctggcta cactgggcgc cctgtgcttt gcagagcttg gcacaatgat
      781 caccaagtca gggggtgagt acccctatct gatggaggcc ttcggcccca tccctgccta
      841 cctcttctcc tggaccagcc tgattgtcat gaagccctca tccttcgcca tcatctgcct
      901 cagcttttca gagtatgtgt gtgcggcctt ttacttaggc tgcaggcctc ctgctgtggt
      961 agtgaaactc ctggctgctg ctgccatctt gcttatcact acagtgaatg cgctgagcgt
     1021 gcggcttggc agctatgtgc agaatgtctt cacggcagcc aagctggtga tcgtcgccat
     1081 catcatcatc agcggactgg tcctcctggc gcaaggaaat gttaagaact ttcagaattc
     1141 ttttgagggt tcacagacct ctgtgggctc catcagcctg gcattttaca acggactctg
     1201 ggcctacgat gggtggaacc aacttaacta catcactgaa gagcttagaa acccttacag
     1261 aaacctgccc atggccattg tcattgggat ccctctggtg acagtatgct acatcctcat
     1321 gaatattgct tacttcacag tgatgacccc aacggagctc ttgcagtccc aggctgtggc
     1381 tgtgaccttc ggagaccgtg ttctctatcc ggcatcttgg gtagtcccac tttttgtggc
     1441 attttcaacc attggtgctg cgaatgggac ctgctttacg gcgggcaggc tcatctatgt
     1501 ggcgggccgg gaaggccaca tgcttaaagt gctatcctac atcagtgtca agcgcctcac
     1561 tccggcccct gccctcgtat tctatggcat aatagccatc atttacatca tccccgggga
     1621 catcaactcc ttagtcaatt atttcagttt tgctgcatgg ctcttttatg gcatgacaat
     1681 cctaggactc gttgtgatga gattcacaag gaaagaccta gagaggccca tcaaggtgcc
     1741 catcttcatc cctatcattg tgattctcgt atctgttttc ttgatcctgg cccccatcat
     1801 cagttcgcca gcctgggaat atctctactg cgtgttgttc atactgagtg gacttatatt
     1861 ttacttcctt tttgtccact acaagttcag atgggcccag aaaatctcca ggccgatcac
     1921 caagcacctg cagatgctga tggaagttgt cccaccagag aaggacccag agtaaaaggc
     1981 ccatcactcg tagcccaaag ctgtgatcaa tttatttttg taagcaatta tttgtggtta
     2041 tttcttcctg gtgtttttct taatgaaaac atgtattcag a
//
LOCUS       NM_001438363            2372 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7),
            transcript variant 4, mRNA.
ACCESSION   NM_001438363 XM_006230894
VERSION     NM_001438363.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230894.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.285090.1,
                                           SRR22399481.2497938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  208444568-208444623
            57-76               JAXUCZ010000001.1  208450269-208450288
            77-168              JAXUCZ010000001.1  208450390-208450481
            169-391             JAXUCZ010000001.1  208451583-208451805
            392-482             JAXUCZ010000001.1  208452757-208452847
            483-696             JAXUCZ010000001.1  208453456-208453669
            697-901             JAXUCZ010000001.1  208455552-208455756
            902-1033            JAXUCZ010000001.1  208457746-208457877
            1034-2372           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2372
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..56
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="Dhcr7"
                     /note="upstream in-frame stop codon"
     exon            57..76
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            77..168
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1498
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_001425292.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     misc_feature    188..250
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    347..1495
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    347..1495
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    365..427
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    512..574
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    599..661
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    779..841
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    866..928
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    986..1048
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1061..1123
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1328..1390
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     exon            169..391
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            392..482
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            483..696
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            697..901
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1033
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..2372
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttag ggcgctgctg gagctcgtga atcaaccgcc cggatcccgc acgcagaacc
       61 tgcggtgggc gatcagatcc tgatggcttc aaagtcccag cacaacgctt ccaaagccaa
      121 gaatcacaac gtcaaggctg aatctcaagg acaatggggc cgtgcctggg aagtggactg
      181 gttctccctg gtcagcgtca ttttcctgct gctcttcgca ccgttcattg tgtactactt
      241 catcatggca tgtgaccagt acagctgctc gctgactgcc cccatattgg acgtagctac
      301 aggccgtgcg agtctggcag acatctgggc caagacaccg cctgtgacag ctaaggctgc
      361 ccaactgtat gccttgtggg tcagcttcca ggtgctgctt tactcctggc ttcctgactt
      421 ctgccacaga tttctgccag gttatgtggg aggcgtccaa gaaggtgcca taactccagc
      481 agggattgta aataagtatg aggtgaatgg gctgcaagcc tggctcatta cccacttcct
      541 ctggtttgtg aacgcttacc tcctatcctg gttctccccc accatcatct ttgacaactg
      601 gatcccgttg ctatggtgtg ccaacatcct gggctacgct gtgtccacct ttgcaatgat
      661 caaggggtac ctgttcccca ccagcgccga agactgcaaa ttcacaggca atttcttcta
      721 caactacatg atggggattg agttcaaccc ccgcatcgga aagtggtttg acttcaagct
      781 gttcttcaat gggcgcccgg ggattgtggc ctggactctt atcaacctgt cctttgctgc
      841 caagcagcag gagctttatg gccatgtgac caactccatg attttggtca atgtcttaca
      901 ggccatctat gtgttagact tcttctggaa cgaaacctgg tacctgaaga ccattgacat
      961 ctgccatgac cactttggat ggtacctggg ctggggagat tgcgtgtggc tgccctacct
     1021 ctacacactg cagggcctgt acttggtgta ccaccctgta cagctctcca cccccaacgc
     1081 cttgggcgtc ctgctgctcg gcctggtggg ttactatatc ttccgaatga ccaaccatca
     1141 gaaggacctg ttccgccgga cagatggaca ctgcctcatc tggggcaaga aacccaaggc
     1201 catcgagtgc tcctacacgt cagccgacgg gctgaagcac cgcagcaagc tgttggtttc
     1261 aggcttctgg ggtgtggccc gccacttcaa ctataccgga gacctgatgg gcagcctcgc
     1321 ctactgcctg gcttgtggcg gcggccacct cctcccctac ttctacatca tctatatgac
     1381 tatcctgctt acccaccgct gcctccgtga tgagcaccgc tgtgccaaca agtatggccg
     1441 tgactgggag cgctacgtag ccgctgtgcc ctaccgcctg ctgcctggga tcttctgagg
     1501 gccaccctgg caagcagaaa gaggcgtcat tgaatgtgtg gagttgggtg catgggggcc
     1561 agcgtccggc tttcccctgc aggggcctcc ttggtttgct cttctggagg atggagagcc
     1621 aggcgcccca cagtgtctgg ctggtggcag ctagagctga gttcacactg atgccccagc
     1681 agaatgactg gttctccctg ttcagcatcc tgagggcaga ggaccttggc cctttcatgt
     1741 ctgttggaag cccaccatct atgttgtcta gatagcttag gcttaccagg tgtctcccag
     1801 gattgggcca tcctggtaaa ctggagacaa tgtaggatct aaagagtttg gcaatgtcac
     1861 cttcactccc acctgcaatg gtgggctgga cccctttttc tgtctgtagt gtgatcagca
     1921 gagggttcag gggccattga aggaggaagg ctctttgttt aggttcttta ctgtttttac
     1981 ccgaggaatg ccaagcagcg gactggaata tcccactctg cacatccctg gctgacttga
     2041 taaagtctgt ctgacatatg agatggggtt cccagaactc cccaagtacc ccagctagca
     2101 gcttatccat ctcccctctt ccggaaggtg cttcttgttt acccctgaga cttggctcag
     2161 aggtgaacag acttggctct gacaacccag aatgtatcac cagttagtgg cctcagccac
     2221 accttcccca acaggagaac cagcgttggg gaaggaatcc attctcatta gtgacactgc
     2281 cccccaaaac tcagggttat tttgtaaaac tagataggct catgttagcc ttgcaagcgg
     2341 ttctttgtat taaatctgcc ttgttaaatg ag
//
LOCUS       NM_001106225            3552 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), transcript
            variant 2, mRNA.
ACCESSION   NM_001106225 XM_001070417 XM_218263
VERSION     NM_001106225.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 3552)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 3552)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 3552)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_001106225.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.1406.1,
                                           SRR26360176.2396593.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  79143873-79144074   c
            203-381             JAXUCZ010000001.1  79140675-79140853   c
            382-493             JAXUCZ010000001.1  79138630-79138741   c
            494-714             JAXUCZ010000001.1  79137661-79137881   c
            715-810             JAXUCZ010000001.1  79135186-79135281   c
            811-883             JAXUCZ010000001.1  79134012-79134084   c
            884-959             JAXUCZ010000001.1  79133654-79133729   c
            960-1015            JAXUCZ010000001.1  79132689-79132744   c
            1016-1108           JAXUCZ010000001.1  79132406-79132498   c
            1109-1201           JAXUCZ010000001.1  79131894-79131986   c
            1202-1344           JAXUCZ010000001.1  79128304-79128446   c
            1345-1390           JAXUCZ010000001.1  79128125-79128170   c
            1391-1464           JAXUCZ010000001.1  79127788-79127861   c
            1465-3552           JAXUCZ010000001.1  79125564-79127651   c
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3552
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..202
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1429
                     /gene="Ttyh1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1 isoform 1"
                     /protein_id="NP_001099695.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
                     "
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    206..268
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    341..403
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    464..466
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    569..571
                     /gene="Ttyh1"
                     /note="Essential for the formation of the channel-pore.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); other site"
     misc_feature    719..781
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    797..859
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    926..928
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    1139..1141
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    1247..1309
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    1358..1426
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1394..1396
                     /gene="Ttyh1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); phosphorylation site"
     exon            203..381
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..714
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..810
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..959
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1015
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1344
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1390
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1464
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3552
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccggct ccgcccgcgc cccgcacagc accgaggctc ccggcccggt ccgccccgct
       61 gcccctcccc ggggccatgg gggcaccccc gggctaccga ccctctgcct gggtgcatct
      121 cctccaccag ctgccccgtg ccgacttcca gctccgcccg gtgcccagcg gctttgctcc
      181 ccgcgaccaa gagtaccagc aggccctgct gctggtggca gccttggctg ggctgggttt
      241 gggcctgagc ctcatcttca tcgctgtcta cctcatccgc ttctgctgct gcaggcctcc
      301 agaaccccct ggggccaaga gtcccccacc cggaggaggc tgtgtcacct ggagctgcat
      361 tgctgccctt ctcgtgggct gtgcaggcat tggcattggt ttctatggta acagcgagac
      421 cagtgatggg gtgtcccagc tcagctcagc actgcagcat gccaaccaca cgctcagcac
      481 cattgatgac ttggtgctgg aaacggtaga gaggctgggt gaggctgtga ggacagagct
      541 gaccaccctg gaggaagtgt tgtcagaacg cgtggagctg gtggctgcca cccggggagc
      601 cagaaggcag gctgaggcag cagctcagca cctgcaaggc ctagccttct ggcagggagt
      661 gtccctgagc ccagtacagg tggctgagga tgtgactttc gtggaggagt acaggtggct
      721 ggcctatgtc ctcctgctgc tcttggtgct tctggtttgt ctcttcaccc tcctgggcct
      781 ggccaagcag agcaagtggc tggtggttgt gatgaccgcc atgagtctcc tggtgcttgt
      841 cctgagctgg ggttctatgg gcctagaggc tgccacagct gtgggtctca gtgacttctg
      901 ctccaaccca gacacctatg tgctgaactt gacccaggag gagacaggaa tcagttcaga
      961 catcctcaac tattatttcc tgtgcaacca ggcggtctcc aaccccttcc aacagaggct
     1021 gactctgtcc cagcgtgctc tagccagcat ccactctcag ctgcaaggcc tggagcggga
     1081 agctagccct caatttcctg ctgcacagaa gcccttgtta tccttggagg agacgctgaa
     1141 tgtgacagaa agaagcttcc accagttggt ggcactgctg cactgccgca gtctgcacaa
     1201 ggactatggc tcagcactcc gaggcctgtg tgaagatgcc ctagagggcc tgctgttcct
     1261 gatgctcttt tctctcctgt ctgccggggc cctagccacc actctttgca gcctgccccg
     1321 tgcctgggct ctcttcccac ccagtgatga ctacgatgac acagacgatg acgacccttt
     1381 caaccctcag gaatccaagc gctttgtgca gtggcagtct tccatctgag cccccctgcc
     1441 agtgtggcct gcctctcctc tttgctcctt tccttggctg ctggagaagg ccccactaac
     1501 ctgaccttgg ctgggctctg accattaaca ctgctggcta tggacacctc acataggatg
     1561 acatcctgtt ctggccctaa cactccccca ttcccatttc tccttagcac aggtggttgc
     1621 tggggtggca caatagagac cagggctgtc tgggaaggga gctgaccata cagcgtggtg
     1681 ttcctcacct ccgggtacca gccctgtcct tggagggata aagctggaca caggtgcagg
     1741 catggccatt tcctgccata tgccagtgat ctcaactgat ggcactaact tggaagaggg
     1801 cggatttgaa ataaaaggga agactttatt ttacaagtac ctaggtcctt cttatcaccc
     1861 ctgccccaat cctggagaaa gaagtcttga ctgggctagg ggactcctct ggtgtttgaa
     1921 aggcaactct cctcttgtcc aggctcagca ctgctttgct tctgaaagtc acgtgtgaat
     1981 cctgacaagg gggaagaagc agatcccaga agagagtaag cctaacacta aattaaacat
     2041 gcgtgcatcc acaggaagag tcaaccttcc agtcacgtgg aatgttcaaa gcctgctggg
     2101 attaggaacg gtgtggaatc gaatcaactt gcttcctagc agctcatatc ctacacaaga
     2161 acgtcagaaa actaacgctt gtttcaggat agggacagaa atcttcagag agaagtagaa
     2221 tatttgctcg taatgctacc acggtgatgt aaagggagaa ggtttaagga agataatata
     2281 aatccagaca ggaaaagatg aggcaatcat caagttgtca agtaaaaaca aacatggcag
     2341 agtcaaaagg gaaatttatt gtctggggaa caattcctat gtagttctta tttgttaaaa
     2401 aaaaaaaaag tagcacacat gacaaaggaa aacattgttg ttaatagata aacataattc
     2461 aaaaagcttc tattatctaa caaaaaacag accaactcaa tttagtaata agtaactgag
     2521 atgaacgtac aaggaaacaa aatccccaag acaaaggata aaactgggga tttttggttt
     2581 tcattttggt ttttggtttt ttgagacagg ctttctttgt aatagacctg ggtgtcctgg
     2641 aactctttgt agaccaggct ggccttgacc tcacagagaa cagcctgcct ctgcctccct
     2701 agtactgaga ttaaagcatg tatcaccata tcaccagcta aaatgttcaa gttctaatga
     2761 ttagcaaaca cgatgtgcta ctttcccctt tctagtacct acttgttgtg gactttaaag
     2821 tggggtgttg gctggtgcta gtctggaggc tcagggaaaa agttctctga atatgctgct
     2881 cagaggcggt gaatcaccag ctatgtgaaa ataataatta aaacaaacaa acaaaacaaa
     2941 accctgctca catctcttaa cctggtaatc ctttggggca caagcttcca gtaagagatg
     3001 aacaggcaac ccttggctca gttaaaccct ggagacagaa atgttcacaa aaggaagaac
     3061 agtaatgtag agcaggatcc tcaagttcac agtggcaagt ggggtacaga ggcaccaggg
     3121 gtatccctgg ccctgtgctg gttggaagcc tctgggtcct agacctggca ccactatgtt
     3181 aatgtggaca agttatctga ctggttgaac ctcagttgaa tggtgaagca aatgggtatc
     3241 ataaatccag aaaacagctc ttgacatgat aggtaataag caggataaat gcagcatgat
     3301 gttctgggtt acattctggt gcacagaaaa cattagtagg aaaagtaccc acttctaaag
     3361 tctgcggctt agttcagagt attaaagcaa tgtcaatttc ttacttttaa caaataaacc
     3421 atggtgaatt cgaggtgtgg aatctagcaa taggggaaac tgggcagtgt gctcaattcc
     3481 tgtattacct ttgcaatttt tatttctgta aacttaaatt tattctaaaa taaaagttca
     3541 ttataaaaag ga
//
LOCUS       NM_001438382            1142 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 196 (Ccdc196),
            transcript variant 5, mRNA.
ACCESSION   NM_001438382 XM_063262312
VERSION     NM_001438382.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 18, 2025 this sequence version replaced XM_063262312.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2110128.1,
                                           SRR26360181.464807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000006.1  102648879-102649073
            196-348             JAXUCZ010000006.1  102649177-102649329
            349-445             JAXUCZ010000006.1  102650498-102650594
            446-523             JAXUCZ010000006.1  102652664-102652741
            524-607             JAXUCZ010000006.1  102652920-102653003
            608-683             JAXUCZ010000006.1  102653465-102653540
            684-1142            JAXUCZ010000006.1  102664042-102664500
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1142
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="coiled-coil domain containing 196"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
     exon            1..195
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    131..133
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="upstream in-frame stop codon"
     CDS             149..661
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="isoform 3 is encoded by transcript variant 5;
                     putative coiled-coil domain-containing protein 196"
                     /codon_start=1
                     /product="putative coiled-coil domain-containing protein
                     196 isoform 3"
                     /protein_id="NP_001425311.1"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
                     /translation="MTSGSNSSESGLSSKRNPKTYDNYLKELNEDLKLRKQELLEMLK
                     PLEDKNNLLLQKLMANLEEKQRSLQIMRQIMAGRGGDESSVEELIKEAQEMKQNLTFE
                     SEELRGQQKALPKKSKADMQDGKAQKSSLSLWKVKSESEKPDIDKVGDIRKIFLPSGK
                     ATEENKMGQI"
     exon            196..348
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            349..445
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            446..523
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            524..607
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            608..683
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1142
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctattgtga cctcagctgt agttgaaatc agtccaatgc aataggagct ctaacaacaa
       61 cagccccaaa atgctgtctt aactgcacag ggaaaggagg cacatagttt ccagaaggcc
      121 tctttattgt taggcgtttc ccttcaagat gacaagtggc tcaaactctt cagaatctgg
      181 tttgtcctca aaaaggaatc ctaaaacata tgacaactac ttgaaagaat tgaacgagga
      241 cttaaagtta aggaagcagg aacttctaga gatgctgaaa cctctggaag ataagaacaa
      301 tctcttattg cagaagttaa tggctaactt ggaggaaaag cagaggagtc tgcagatcat
      361 gaggcagatc atggccggga ggggaggtga tgaatcttca gtcgaggagc ttattaagga
      421 agcccaggag atgaagcaga acctgacatt tgagtcagaa gagctccgtg gtcaacagaa
      481 agcattacca aaaaagtcca aggcagacat gcaagatggg aaggctcaga aatcctcctt
      541 atcactttgg aaggtcaaga gtgagtcaga gaaaccagac atcgacaaag tgggagacat
      601 acggaagatc tttcttccat caggaaaagc aacagaggaa aataaaatgg gtcaaatatg
      661 aggagcaacc caacatcctt cagagaatcc caggatcaaa gagctacaag aaggaactag
      721 agaaagtcat atgatgatgt aggacagagg ctcttttttc tgaagtcaat gccagatgaa
      781 gctctgaagg attagaaggc tttcactaca tttgctttgg acagatgcga agactaggta
      841 cggcctttct gttcactaaa atctctcaaa cctttatttt agttccgttc ttccattcta
      901 ccaccaaact gtgggagcga tgttgttcat tttggccctc agcgtgttgg ggcttcagtc
      961 taggtattgt aaacagccac tagttatgtt ggtaaatttt gggtgaaatg actggatttc
     1021 acattgttta taaactatag ctaaattcat aggaagacat tttttttacc actgaggtat
     1081 ttcctgatca ctgctggcga gtaagcagta ggtgaaaata aaaaaaaaaa atgctatccc
     1141 tg
//
LOCUS       NM_001438381            1165 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 196 (Ccdc196),
            transcript variant 4, mRNA.
ACCESSION   NM_001438381 XM_063262311
VERSION     NM_001438381.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 18, 2025 this sequence version replaced XM_063262311.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.35860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000006.1  102646152-102646188
            38-248              JAXUCZ010000006.1  102647044-102647254
            249-310             JAXUCZ010000006.1  102649012-102649073
            311-463             JAXUCZ010000006.1  102649177-102649329
            464-560             JAXUCZ010000006.1  102650498-102650594
            561-638             JAXUCZ010000006.1  102652664-102652741
            639-722             JAXUCZ010000006.1  102652920-102653003
            723-801             JAXUCZ010000006.1  102653462-102653540
            802-1165            JAXUCZ010000006.1  102661110-102661473
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1165
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="coiled-coil domain containing 196"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
     exon            1..37
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            38..248
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    246..248
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="upstream in-frame stop codon"
     exon            249..310
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..779
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="isoform 2 is encoded by transcript variant 4;
                     putative coiled-coil domain-containing protein 196"
                     /codon_start=1
                     /product="putative coiled-coil domain-containing protein
                     196 isoform 2"
                     /protein_id="NP_001425310.1"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
                     /translation="MTSGSNSSESGLSSKRNPKTYDNYLKELNEDLKLRKQELLEMLK
                     PLEDKNNLLLQKLMANLEEKQRSLQIMRQIMAGRGGDESSVEELIKEAQEMKQNLTFE
                     SEELRGQQKALPKKSKADMQDGKAQKSSLSLWKVKSESEKPDIDKVGDIRKKIFLPSG
                     KATEENKMGQI"
     exon            311..463
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            464..560
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            561..638
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            639..722
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            723..801
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1165
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcggaat cattcacaag caagggcaga gaagaagtgc aaaggtttgc ctttcaaatt
       61 tccccaaaga taaaggactg aaactacttt ggaaaaaact cctcgaaaag tgtttggtca
      121 gtgtttgaaa cagcaagcct taaattttat ccgtgatgtc acataaaaat gaattcataa
      181 aactttttaa agggcacatt taaaaatata tggttccttg gactgtcttc tacttcttag
      241 tggcataggc gtttcccttc aagatgacaa gtggctcaaa ctcttcagaa tctggtttgt
      301 cctcaaaaag gaatcctaaa acatatgaca actacttgaa agaattgaac gaggacttaa
      361 agttaaggaa gcaggaactt ctagagatgc tgaaacctct ggaagataag aacaatctct
      421 tattgcagaa gttaatggct aacttggagg aaaagcagag gagtctgcag atcatgaggc
      481 agatcatggc cgggagggga ggtgatgaat cttcagtcga ggagcttatt aaggaagccc
      541 aggagatgaa gcagaacctg acatttgagt cagaagagct ccgtggtcaa cagaaagcat
      601 taccaaaaaa gtccaaggca gacatgcaag atgggaaggc tcagaaatcc tccttatcac
      661 tttggaaggt caagagtgag tcagagaaac cagacatcga caaagtggga gacatacgga
      721 agaagatctt tcttccatca ggaaaagcaa cagaggaaaa taaaatgggt caaatatgag
      781 gagcaaccca acatccttca ggcctaaaaa ttatgatggg actctaaact taactctata
      841 gtgtcctcct cccaaagaag aatcacggcc cctgaggctg tttttagaga atgtttacaa
      901 atgggttgga aggcctgtaa ttatgtattt agtccggtag gtggcaccaa ccacatctaa
      961 gccacgtcca taacaaatgg tgattcggga aatgtgaaat gatgtaggag acgactggct
     1021 ttctattacc ccgaggacaa aatgtgccac atttataaac caaatgaaaa aacaacctat
     1081 cgatgtgttg tgtcgtgtta tatggcatca agatgtatta ctggcagtct tgattaaaga
     1141 ttaaacacgg tgttccgttg tgcaa
//
LOCUS       NM_001438380            1208 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 196 (Ccdc196),
            transcript variant 3, mRNA.
ACCESSION   NM_001438380 XM_039112727
VERSION     NM_001438380.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 18, 2025 this sequence version replaced XM_039112727.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.860785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000006.1  102646152-102646188
            38-248              JAXUCZ010000006.1  102647044-102647254
            249-353             JAXUCZ010000006.1  102648969-102649073
            354-506             JAXUCZ010000006.1  102649177-102649329
            507-603             JAXUCZ010000006.1  102650498-102650594
            604-681             JAXUCZ010000006.1  102652664-102652741
            682-765             JAXUCZ010000006.1  102652920-102653003
            766-844             JAXUCZ010000006.1  102653462-102653540
            845-1208            JAXUCZ010000006.1  102661110-102661473
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1208
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="coiled-coil domain containing 196"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
     exon            1..37
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            38..248
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            249..353
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    289..291
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="upstream in-frame stop codon"
     CDS             307..822
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="isoform 2 is encoded by transcript variant 3;
                     putative coiled-coil domain-containing protein 196"
                     /codon_start=1
                     /product="putative coiled-coil domain-containing protein
                     196 isoform 2"
                     /protein_id="NP_001425309.1"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
                     /translation="MTSGSNSSESGLSSKRNPKTYDNYLKELNEDLKLRKQELLEMLK
                     PLEDKNNLLLQKLMANLEEKQRSLQIMRQIMAGRGGDESSVEELIKEAQEMKQNLTFE
                     SEELRGQQKALPKKSKADMQDGKAQKSSLSLWKVKSESEKPDIDKVGDIRKKIFLPSG
                     KATEENKMGQI"
     exon            354..506
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            507..603
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            604..681
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            682..765
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            766..844
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1208
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcggaat cattcacaag caagggcaga gaagaagtgc aaaggtttgc ctttcaaatt
       61 tccccaaaga taaaggactg aaactacttt ggaaaaaact cctcgaaaag tgtttggtca
      121 gtgtttgaaa cagcaagcct taaattttat ccgtgatgtc acataaaaat gaattcataa
      181 aactttttaa agggcacatt taaaaatata tggttccttg gactgtcttc tacttcttag
      241 tggcataggg aaaggaggca catagtttcc agaaggcctc tttattgtta ggcgtttccc
      301 ttcaagatga caagtggctc aaactcttca gaatctggtt tgtcctcaaa aaggaatcct
      361 aaaacatatg acaactactt gaaagaattg aacgaggact taaagttaag gaagcaggaa
      421 cttctagaga tgctgaaacc tctggaagat aagaacaatc tcttattgca gaagttaatg
      481 gctaacttgg aggaaaagca gaggagtctg cagatcatga ggcagatcat ggccgggagg
      541 ggaggtgatg aatcttcagt cgaggagctt attaaggaag cccaggagat gaagcagaac
      601 ctgacatttg agtcagaaga gctccgtggt caacagaaag cattaccaaa aaagtccaag
      661 gcagacatgc aagatgggaa ggctcagaaa tcctccttat cactttggaa ggtcaagagt
      721 gagtcagaga aaccagacat cgacaaagtg ggagacatac ggaagaagat ctttcttcca
      781 tcaggaaaag caacagagga aaataaaatg ggtcaaatat gaggagcaac ccaacatcct
      841 tcaggcctaa aaattatgat gggactctaa acttaactct atagtgtcct cctcccaaag
      901 aagaatcacg gcccctgagg ctgtttttag agaatgttta caaatgggtt ggaaggcctg
      961 taattatgta tttagtccgg taggtggcac caaccacatc taagccacgt ccataacaaa
     1021 tggtgattcg ggaaatgtga aatgatgtag gagacgactg gctttctatt accccgagga
     1081 caaaatgtgc cacatttata aaccaaatga aaaaacaacc tatcgatgtg ttgtgtcgtg
     1141 ttatatggca tcaagatgta ttactggcag tcttgattaa agattaaaca cggtgttccg
     1201 ttgtgcaa
//
LOCUS       NM_001108740            2962 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus cytoskeleton-associated protein 4 (Ckap4), mRNA.
ACCESSION   NM_001108740 XM_001079545 XM_343189
VERSION     NM_001108740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Kazi,A.S., Tao,J.Q., Feinstein,S.I., Zhang,L., Fisher,A.B. and
            Bates,S.R.
  TITLE     Role of the PI3-kinase signaling pathway in trafficking of the
            surfactant protein A receptor P63 (CKAP4) on type II pneumocytes
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 299 (6), L794-L807 (2010)
   PUBMED   20870746
  REMARK    GeneRIF: Data demonstrate an important role for the PI3-kinase-Akt
            pathway in intracellular transport of surfactant protein A receptor
            P63.
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Iinuma,T., Aoki,T., Arasaki,K., Hirose,H., Yamamoto,A., Samata,R.,
            Hauri,H.P., Arimitsu,N., Tagaya,M. and Tani,K.
  TITLE     Role of syntaxin 18 in the organization of endoplasmic reticulum
            subdomains
  JOURNAL   J Cell Sci 122 (Pt 10), 1680-1690 (2009)
   PUBMED   19401338
REFERENCE   8  (bases 1 to 2962)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 2962)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   10 (bases 1 to 2962)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 18, 2025 this sequence version replaced NM_001108740.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.726787.1,
                                           SRR26643297.24627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               JAXUCZ010000007.1  21118106-21118703
            599-2962            JAXUCZ010000007.1  21124254-21126617
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2962
                     /gene="Ckap4"
                     /note="cytoskeleton-associated protein 4"
                     /db_xref="GeneID:362859"
                     /db_xref="RGD:1311989"
     exon            1..598
                     /gene="Ckap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1906
                     /gene="Ckap4"
                     /codon_start=1
                     /product="cytoskeleton-associated protein 4"
                     /protein_id="NP_001102210.2"
                     /db_xref="GeneID:362859"
                     /db_xref="RGD:1311989"
                     /translation="MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPPAPQQPQ
                     PPAPHPPQHPQNQAHRGGHRGRSSTAAAAASSASCSRRLGRLLNFLFYLSLVAAAAFS
                     GWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQAAVGTFESILRSSQH
                     KQDLTEKAVKEGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEE
                     RLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKVLKEAVKEV
                     QASMKSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTE
                     KLLQSEESSSRLPEDIRRLEEELQQLKVGAHGSEEAVVFRDSKAFDELQKQMEGLGAR
                     LQYVEDGVYSMQVASASHTESLESLLSKSQEYEQRLAMLQEHVESLGPISDLASTVRS
                     LEETQLALSSDLKGLKQGLGELPGTVESLQEQVHLLLSQDPAQAAGLPPQDFLDRLSS
                     LDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENSLESAKGLLDDLRNDLDRLFV
                     KVEKIHEKI"
     misc_feature    503..>1615
                     /gene="Ckap4"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    503..>1615
                     /gene="Ckap4"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     exon            599..2962
                     /gene="Ckap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccgcggc cggcctcctt cctcgtcgcc ccacgttccg ggccgctccg acgccgccgc
       61 gcccgcgtgc cgcccgcgca gtccccgtgg gagcccgagc cagcgtcccg ggctgcgcgc
      121 cccgctcgcc catcccgccg ccgccgccgc cgccgccgcc gccgccgccg ccgccgccat
      181 gccctcggcc aaacaaaggg gctccaaggg cggccacggc gccgcgagcc cctcggacaa
      241 gggcgcccac ccgtcgggcg gcgcggatga cgtggcgaag aagccgccgc cggcgccgca
      301 gcagccgcag ccgcccgcgc cgcacccgcc gcagcacccg cagaatcagg cgcaccgggg
      361 cggccaccgc ggcaggtcct cgaccgccgc cgccgccgcg tcctctgcgt cctgttcgcg
      421 caggcttggc cggctgctca actttctctt ctacctctcc ctggtggcgg cggccgcctt
      481 ctccggctgg tatgtccatc acgtcctgga agaggtccag caggtccggc gtggccacca
      541 ggacttctcc cgtcagaggg atgagctggg ccagggcttg cagggcgtcg agcagaaggt
      601 acagtctctg caagccgcag tcgggacctt cgagtccatc ctgagaagtt cccagcataa
      661 acaggatctc acagagaaag ccgtgaagga aggggagagt gagatcaacc gtattagtga
      721 agttctacag aagctgcaga atgagattct caaagacctg tcggacggga tccacgtggt
      781 gaaggatgcc cgagagcggg acttcacgtc cctggagaac acggtcgagg agcgtctgac
      841 ggagctcacc aagtccatca atgacaacat cgccatcttc accgacgtac agaaaaggag
      901 ccagaaggag ataaatgagg tcaagatgaa ggttgcctcc ttggaagaat ccaaggggga
      961 ccgcagtcag gacgtgaaag tcctgaagga agccgtgaag gaggtgcagg cctccatgaa
     1021 gtctcgagag agggacatcg aggccctcaa gagttccctt cagaccatgg agtccgatgt
     1081 ctacacagag gtccgggagc tagtgagcct gaagcaggag cagcaggcat tcaagcaggc
     1141 ggccgactca gagcgcctgg ctctgcaggc cctcacggag aagcttctgc agtccgaaga
     1201 gtcctcctct cgtctcccag aggacatcag gagactggag gaagagctgc agcagctgaa
     1261 ggtgggagcc cacgggtcag aggaggccgt ggtcttcaga gactcgaaag ccttcgacga
     1321 actccagaag cagatggagg gcctaggcgc caggctccag tatgtagagg acggggtcta
     1381 ctcgatgcag gtggcttctg cgagccacac tgagagcctg gagtcgctcc tgtccaagag
     1441 ccaggagtac gagcaacgcc tggccatgct gcaggagcac gtagaaagcc tggggcctat
     1501 ctctgacctg gccagcacgg tgaggagcct ggaggagacc cagctggcgc tctccagcga
     1561 cttgaagggg ctgaagcaag gcttgggtga gctgccaggg actgtggagt cgctgcagga
     1621 gcaagtgcat ttgctgctca gccaggaccc agcccaggcc gcgggcttgc ctcctcagga
     1681 cttcctggat agactctcct ctctagacaa cctgaaatcc tcagtaagcc aagtggaatc
     1741 agacttgaaa atgctcagga cggctgtgga cagtttggtt gcctactctg ttaaaatcga
     1801 aacgaacgag aatagcttag agtccgccaa gggcctgctg gacgaccttc ggaatgatct
     1861 ggataggttg ttcgtgaaag tcgagaagat ccatgaaaag atctgaacga accgggtgtg
     1921 tgggcccact ttcttacgac caaaaaaaca aaacaaaaca aaaaaaaccc attgtttcct
     1981 cccaggtgcc ctccccgcca ccttctcggc cctgccccac cccatggaga gcagcagaca
     2041 ccagctgaag gtgttccggc tctggttaat ttgtgtgcag atattaccac atgcctttgg
     2101 tttcttaagt cctgtttctg cttttggtta ggcttcctga aggcccagcc ctgtgcagaa
     2161 aaggatgggt ctcctgctag gaagatgatg gctgtggctt taactgggga ttatcaggaa
     2221 gcagattaac cttaaaaaaa aaaaatcctg tcaggctgac agatttatag taaaatagaa
     2281 aaaaacaaca aagaacaggt ggggggcacg ttttttttag tctttaaaga aaattaattt
     2341 tattgttttt ttttttatac tcctagccag ggtttttatg agctggccct taacttgtct
     2401 tccatttaga actggtaaaa actcgtagat gtcagctctg aatgggtgaa agaggccccc
     2461 ctcccccaac ctgcctgagg gtcactttca gaagcatggt gtctctgtct ctctctctct
     2521 ctctctctct aatctagtca taaggtaact atgcaaatgt gtcaccaggc taggctgggt
     2581 caccaagtaa atttgggacc ctagaggggg aggttcttcg ggttctgatg tgagagctgt
     2641 cttttccaca aaggattcgg gcatcaccct gggagatgga ggccaggcct ttttgtttta
     2701 tcacaggacc tctggagagg tctctgcccc tgtctgtcag tgaggatcac gtgtgctgca
     2761 tgtgttctca ctgtaccctc gcccctttga gaggtattgt ctttaatgac tgccttgccc
     2821 ttcccacccc ccacccccca aaaaaagaaa aaaagaaaaa aactgaaaag aaaaacaaag
     2881 tttgttagtt tactgtgaaa tgaactgtat ggcttattta cagtattttt aattcttaat
     2941 aaacacttga gctttgttat ga
//
LOCUS       NM_022698               1420 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 4, mRNA.
ACCESSION   NM_022698
VERSION     NM_022698.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_022698.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.6867.1,
                                           SRR26643297.4443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JAXUCZ010000001.1  213562696-213563231
            537-719             JAXUCZ010000001.1  213563668-213563850
            720-910             JAXUCZ010000001.1  213570794-213570984
            911-1420            JAXUCZ010000001.1  213571525-213572034
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1420
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..536
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    341..343
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="upstream in-frame stop codon"
     CDS             419..1036
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 4 is encoded by transcript variant 4; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 4"
                     /protein_id="NP_073189.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMF
                     QIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGA
                     GTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFE
                     GSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ"
     misc_feature    419..835
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35147.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    545..1033
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    545..1033
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    617..619
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    755..757
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    803..805
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    812..814
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); methylation site"
     misc_feature    818..820
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); methylation site"
     misc_feature    821..823
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    827..829
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine, by PKA, PKB, PAK1, RPS6KA1, RPS6KB1
                     and PKC/PRKCQ. /evidence=ECO:0000250|UniProtKB:Q61337;
                     propagated from UniProtKB/Swiss-Prot (O35147.2);
                     phosphorylation site"
     misc_feature    860..904
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35147.2);
                     Region: BH3"
     misc_feature    884..886
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     misc_feature    899..958
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="propagated from UniProtKB/Swiss-Prot (O35147.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    929..931
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92934; propagated from
                     UniProtKB/Swiss-Prot (O35147.2); phosphorylation site"
     exon            537..719
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..910
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1420
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcagg ccccgcgctc cggcctgcag cagagcccct tagagcccca cggctcgccc
       61 tcctgggctc ccctgtccat tcttccgcac ccgggcggcc atcctgccgg aaaggagctc
      121 ccgagatggc gcggggagtt gtccccaagg caggtagtgc aaggcttcca cgaccgggag
      181 gaggaaggag ctggtcttcc catcccggtc actcggtcca ggggaagcaa taaccatcgc
      241 aaagatcatt gcatccgacg gccaagcttc agtgaatgac tctataagta atcactaagc
      301 tgtttacaga gttttcacta gctcctcagg gaggtgtcat tagccccatt ttacaggagg
      361 aattcaggcc cagaagggct ggaggactta tcagccgaag caggcctcca ggatccaaat
      421 gggaacccca aagcagccct cgctggctcc tgcacacgcc ctaggcttga ggaagtccga
      481 tcccggaatc cggagcctgg ggagcgacgc gggaggaagg cggtggagac cagcagccca
      541 gagtatgttc cagatcccag agtttgagcc gagtgagcag gaagacgcta gtactacaga
      601 taggggcctg ggccctagcc tcactgagga ccagccaggt ccctacctgg ccccaggtct
      661 cctggggagc atcgttcagc agcagccggg acaggcagcc aataacagtc atcatggagg
      721 cgctgggact atggagaccc ggagtcgcca cagttcgtac ccagcgggga ctgaggaaga
      781 tgaagggatg gaggaggagc ttagcccttt tcgaggacgc tcgcgctcgg ctccccccaa
      841 tctctgggca gcgcagcgct atggccgtga gctccgaaga atgagcgatg aatttgaggg
      901 ttccttcaag ggacttcctc gcccaaagag cgcaggcact gcaacacaga tgcgacaaag
      961 cgccagttgg acgcgcatta tccagtcctg gtgggatcga aatttgggga aaggaggctc
     1021 cactccctcc cagtgatctg ctccacattc ccggaattct acccgctccc atcgcccgcc
     1081 atattgggtg tgggcggaag tctttcgagg ccttaggaaa aaaggatcgc tgtgtccctt
     1141 taacagggag aagagctgac gtacagcgtt gagttccttc cggtgcgtgc aatagccatg
     1201 gaggggtggc ccttgctttg gagttttcaa agttttccac acaccctacc ccctacgcct
     1261 ccggaagtgg ctatgttccc tctccgttac tggacagccc tcaggcgcct gtgctaagtt
     1321 gcgagtcctg gtaaaccgag actgggtgct gtcctatcat cctagctgga ggccccaggt
     1381 cgggagaaac gtgctttata ataaagcccg cgcatgtgtc
//
LOCUS       NM_001438407            1286 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 6, mRNA.
ACCESSION   NM_001438407 XM_063272784
VERSION     NM_001438407.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1286)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1286)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1286)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_063272784.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.852746.1,
                                           SRR22582416.1093629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000001.1  213562696-213562848
            154-333             JAXUCZ010000001.1  213563052-213563231
            334-516             JAXUCZ010000001.1  213563668-213563850
            517-1286            JAXUCZ010000001.1  213564268-213565037
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1286
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..153
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..533
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 6 is encoded by transcript variant 6; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 6"
                     /protein_id="NP_001425336.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MARGVVPKAGGIQAQKGWRTYQPKQASRIQMGTPKQPSLAPAHA
                     LGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQ
                     PGPYLAPGLLGSIVQQQPGQAANNSHHGDGAGR"
     misc_feature    342..>527
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    342..>527
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            154..333
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..516
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1286
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcagg ccccgcgctc cggcctgcag cagagcccct tagagcccca cggctcgccc
       61 tcctgggctc ccctgtccat tcttccgcac ccgggcggcc atcctgccgg aaaggagctc
      121 ccgagatggc gcggggagtt gtccccaagg caggaggaat tcaggcccag aagggctgga
      181 ggacttatca gccgaagcag gcctccagga tccaaatggg aaccccaaag cagccctcgc
      241 tggctcctgc acacgcccta ggcttgagga agtccgatcc cggaatccgg agcctgggga
      301 gcgacgcggg aggaaggcgg tggagaccag cagcccagag tatgttccag atcccagagt
      361 ttgagccgag tgagcaggaa gacgctagta ctacagatag gggcctgggc cctagcctca
      421 ctgaggacca gccaggtccc tacctggccc caggtctcct ggggagcatc gttcagcagc
      481 agccgggaca ggcagccaat aacagtcatc atggagatgg agcaggcagg tgaccctaag
      541 tgacaagcca gagccgtgtg aagttggaaa gaggaagacg gagaggcgtt ggaagacact
      601 ggttatactt tccacttccc atcgctgacc ccgtaacagc cacagaaacc tgagctcaac
      661 caggtttgtc actggctcca tagagcttaa attatcccta ccccattatg tttccctgaa
      721 ctgcttcaag ctcccacaca gctgagactg gcctctacct cccaagtact aggaccacag
      781 gccaccgtgc ctggcattcc accttctttt taaaattatg tgtatatgtg tgccattgta
      841 aaatgcacat gtgcaagtgt gggggccttg caagccagaa gagggcgctg gatcccctaa
      901 agctggagtt acaggtggtt gtgagctgcc ccacctcttt gctgggaact gaactcatgt
      961 cctctgcaag agcagcaaat gccctgaacg actgagccat ttttccagtc cccacccctt
     1021 ttaaccttca ggtttcttta ttatcatcat catcatcatc atcatcatca tcatcatcat
     1081 ttattttttt gtttttcaag acaaggtttc tctatgtatc cctggctgtc ctggaactct
     1141 ctctttagac caggctagcc tggaactcag agatctgcct ctgcctccca gtgtggggat
     1201 taaagacatg cactgccact gctgagcaat ctccagattt ctttttcttt cctttttaaa
     1261 aaaaataaaa tgtttattta atgtga
//
LOCUS       NM_001438429            4805 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit alpha 2
            (Ap2a2), transcript variant 3, mRNA.
ACCESSION   NM_001438429
VERSION     NM_001438429.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4805)
  AUTHORS   Capella,P., Asensio,J., Troncoso,M., Sosa,M.A. and Seltzer,A.M.
  TITLE     Evidence on differential role for alpha 1 and alpha 2 subtypes of
            AP-2 adaptin in the central nervous system
  JOURNAL   Neurosci Lett 808, 137282 (2023)
   PUBMED   37127089
  REMARK    GeneRIF: Evidence on differential role for alpha 1 and alpha 2
            subtypes of AP-2 adaptin in the central nervous system.
REFERENCE   2  (bases 1 to 4805)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 4805)
  AUTHORS   Marcello,E., Saraceno,C., Musardo,S., Vara,H., de la Fuente,A.G.,
            Pelucchi,S., Di Marino,D., Borroni,B., Tramontano,A.,
            Perez-Otano,I., Padovani,A., Giustetto,M., Gardoni,F. and Di
            Luca,M.
  TITLE     Endocytosis of synaptic ADAM10 in neuronal plasticity and
            Alzheimer's disease
  JOURNAL   J Clin Invest 123 (6), 2523-2538 (2013)
   PUBMED   23676497
REFERENCE   4  (bases 1 to 4805)
  AUTHORS   Duncker,S.V., Franz,C., Kuhn,S., Schulte,U., Campanelli,D.,
            Brandt,N., Hirt,B., Fakler,B., Blin,N., Ruth,P., Engel,J.,
            Marcotti,W., Zimmermann,U. and Knipper,M.
  TITLE     Otoferlin couples to clathrin-mediated endocytosis in mature
            cochlear inner hair cells
  JOURNAL   J Neurosci 33 (22), 9508-9519 (2013)
   PUBMED   23719817
REFERENCE   5  (bases 1 to 4805)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4805)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   7  (bases 1 to 4805)
  AUTHORS   Voglmaier,S.M., Keen,J.H., Murphy,J.E., Ferris,C.D.,
            Prestwich,G.D., Snyder,S.H. and Theibert,A.B.
  TITLE     Inositol hexakisphosphate receptor identified as the clathrin
            assembly protein AP-2
  JOURNAL   Biochem Biophys Res Commun 187 (1), 158-163 (1992)
   PUBMED   1325787
REFERENCE   8  (bases 1 to 4805)
  AUTHORS   Bahler,M., Klein,R.L., Wang,J.K., Benfenati,F. and Greengard,P.
  TITLE     A novel synaptic vesicle-associated phosphoprotein: SVAPP-120
  JOURNAL   J Neurochem 57 (2), 423-430 (1991)
   PUBMED   2072093
  REMARK    Erratum:[J Neurochem 1991 Dec;57(6):2155]
REFERENCE   9  (bases 1 to 4805)
  AUTHORS   Tucker,K.L., Nathanson,K. and Kirchhausen,T.
  TITLE     Sequence of the rat alpha c large chain of the clathrin associated
            protein complex AP-2
  JOURNAL   Nucleic Acids Res 18 (17), 5306 (1990)
   PUBMED   2402467
REFERENCE   10 (bases 1 to 4805)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1892473.1,
                                           SRR26643284.1607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000001.1  206081886-206082075
            191-393             JAXUCZ010000001.1  206089428-206089630
            394-462             JAXUCZ010000001.1  206110540-206110608
            463-605             JAXUCZ010000001.1  206122048-206122190
            606-799             JAXUCZ010000001.1  206123371-206123564
            800-929             JAXUCZ010000001.1  206126691-206126820
            930-1031            JAXUCZ010000001.1  206129200-206129301
            1032-1140           JAXUCZ010000001.1  206133896-206134004
            1141-1288           JAXUCZ010000001.1  206135412-206135559
            1289-1457           JAXUCZ010000001.1  206136668-206136836
            1458-1595           JAXUCZ010000001.1  206138182-206138319
            1596-1778           JAXUCZ010000001.1  206142657-206142839
            1779-1876           JAXUCZ010000001.1  206143286-206143383
            1877-2108           JAXUCZ010000001.1  206143617-206143848
            2109-2282           JAXUCZ010000001.1  206143939-206144112
            2283-2446           JAXUCZ010000001.1  206146543-206146706
            2447-2529           JAXUCZ010000001.1  206148953-206149035
            2530-2619           JAXUCZ010000001.1  206150081-206150170
            2620-2743           JAXUCZ010000001.1  206151363-206151486
            2744-2860           JAXUCZ010000001.1  206152233-206152349
            2861-2930           JAXUCZ010000001.1  206152458-206152527
            2931-3065           JAXUCZ010000001.1  206152617-206152751
            3066-4805           JAXUCZ010000001.1  206153413-206155152
FEATURES             Location/Qualifiers
     source          1..4805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4805
                     /gene="Ap2a2"
                     /note="adaptor related protein complex 2 subunit alpha 2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
     exon            1..190
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..393
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    372..374
                     /gene="Ap2a2"
                     /note="upstream in-frame stop codon"
     exon            394..462
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..605
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             555..3143
                     /gene="Ap2a2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     adaptor protein complex AP-2, alpha 2 subunit; AP-2
                     complex subunit alpha-2; alpha2-adaptin; alpha-adaptin C;
                     100 kDa coated vesicle protein C; adaptor protein complex
                     AP-2 subunit alpha-2; adaptor-related protein complex 2,
                     alpha 2 subunit; adapter-related protein complex 2 alpha-2
                     subunit; clathrin assembly protein complex 2 alpha-C large
                     chain; plasma membrane adaptor HA2/AP2 adaptin alpha C
                     subunit; adapter-related protein complex 2 subunit
                     alpha-2"
                     /codon_start=1
                     /product="AP-2 complex subunit alpha-2 isoform 3"
                     /protein_id="NP_001425358.1"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
                     /translation="MEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL
                     ASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRT
                     SPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRI
                     VTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPP
                     KSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESM
                     CTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLS
                     YLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIV
                     INRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLH
                     SKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSDSQLKNADVELQQRAVEYLR
                     LSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEETKRERSIDVNGGP
                     EPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGGLLVDVFSDSASAVAPLAPG
                     SEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLIC
                     ADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTEAPVLNIQFRYGGTFQNVSV
                     KLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEITKAKIIGFGS
                     ALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQMYRLTLRTSKDTVSQRLCE
                     LLSEQF"
     misc_feature    555..2096
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    555..2096
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    1317..1388
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1317..1388
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1428..1517
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1428..1517
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1545..1625
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1545..1625
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    2472..2783
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2472..2783
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2799..3125
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     misc_feature    2799..3125
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     exon            606..799
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..929
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1031
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1140
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1288
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1457
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1595
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1778
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1876
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2108
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2282
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2446
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2529
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2619
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2743
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2860
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2930
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3065
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..4805
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggcgct cgggggcccg aggcggctgt ggctaggcgg ctccgcgctc cagggctact
       61 cggcgtgacg gccgcgcccg ttctgttcca gcccgccgcc gaggccgctc ccgggtcgca
      121 aagatgccgg ccgtatccaa gggggagggg atgcgaggcc tagcggtctt catctccgat
      181 atccgtaact aggcaggagg actgtgtgtt tgatgtcagc ttgggtttca cattaaaatg
      241 ccatcacaaa gaaaaaaaaa accctcctga acctgcaaag cacagtggac tggcactgcc
      301 attgagatgg caggatgggc gcctgcctgg tgatttctca gatctggagt ggtaccgacc
      361 gacaccctgc ctgacggagc tctctgattg gaggtaaaag taaagaagct gaaataaaga
      421 ggataaataa ggagctggca aatattagat caaaatttaa aggtgacaag gctcttgatg
      481 gctacagtaa gaagaagtat gtctgcaagt tactcttcat ctttctcctt ggtcatgaca
      541 ttgactttgg acacatggaa gctgtgaatc ttctgagctc aaacagatac acggaaaagc
      601 agatcggcta ccttttcatc tctgtattgg tgaattcaaa tagtgaactg atccggttga
      661 ttaacaatgc catcaagaat gacctggcca gccgcaatcc tacatttatg ggtctggccc
      721 tgcactgcat cgccaatgtg ggtagccgtg agatggcaga ggccttcgct ggagagatcc
      781 ccaagatcct ggtggcagga gataccatgg acagtgtgaa gcagagcgca gccctgtgct
      841 tgttgcgcct gtacaggacg tcacctgacc tagttcctat gggcgactgg acatcccgtg
      901 tggtacacct cctcaatgac cagcacttgg gtgtagtgac tgccgcaact agcctcatca
      961 ccacactggc ccagaagaat cctgaggagt tcaagacctc tgtctctcta gctgtctctc
     1021 gactgagcag aattgtgacg tccgcgtcaa cagatcttca ggattatact tactactttg
     1081 tcccggctcc ttggctgtca gtcaaacttc tgagactgct gcagtgctac ccacccccag
     1141 accctgcggt gcgtggccgc ctgactgagt gcttggagac catcctgaat aaggcccagg
     1201 agccccccaa gtccaagaaa gtccagcatt caaatgccaa gaacgctgtg ctgtttgagg
     1261 ccatcagcct catcatccac catgacagtg agcccaacct cctggtccgt gcctgcaacc
     1321 agctgggcca gttcctgcag catcgggaga caaacctgcg ctacctggct ctggagagca
     1381 tgtgcacact ggccagctct gagttctctc acgaggctgt caagacccac atcgagactg
     1441 tcatcaatgc cttgaagacg gaacgagatg tgagtgtgcg gcagcgggca gtggacctgc
     1501 tctacgccat gtgcgaccga agcaacgccc agcagattgt ggctgagatg ctgagctacc
     1561 tagaaacagc tgactactcc atccgggagg aaattgtgct gaaggtggcc atccttgctg
     1621 agaagtatgc agtggactac acttggtatg tggacaccat cctcaacctc atccgcattg
     1681 caggcgacta tgtgagcgaa gaggtgtggt accgcgtcat ccagattgtc atcaatcgcg
     1741 atgatgtgca gggttatgct gccaagacgg tgtttgaggc attgcaggct ccagcatgtc
     1801 atgagaactt ggtcaaagtg ggcggctaca tcctgggcga gtttggaaac ttgatagcgg
     1861 gagacccacg atccagccct ctgatccagt tcaacctgct ccactccaag ttccacttgt
     1921 gcagcgtccc cactcgggca ctcctgctgt ccacctacat caagttcgtg aacctctttc
     1981 cagaggtaaa ggctaccatt caggacgtgc tgcgcagtga cagccaactg aagaacgcag
     2041 atgtggagct gcagcagcgg gctgtggagt acctgcgact gagtactgtt gccagcactg
     2101 atatcctggc aactgtcctg gaagaaatgc cacccttccc tgagcgtgag tcctccatct
     2161 tggccaagct gaagaagaag aagggcccaa gcacagtgac tgacctggag gagaccaagc
     2221 gtgagcgaag catcgatgtg aatgggggcc ccgaacccgt tccagccagc accagtgctg
     2281 cgtccacacc ttctccatca gcagacctgc tgggtctggg ggccgttccc cctgctccca
     2341 cagggccccc tcccacctct ggcggtgggt tactggtgga cgtgttctca gactcagctt
     2401 ctgcagttgc acctcttgca cccggctctg aagacaactt tgccaggttt gtttgtaaaa
     2461 acaatggtgt gttgtttgaa aaccagctgc ttcaaattgg actgaagtca gaatttcggc
     2521 agaatttagg tcgaatgttc atattttatg gtaacaagac ctccacgcag ttcctaaact
     2581 tcactccaac actaatctgt gctgacgacc ttcagactaa tctgaacctg cagactaagc
     2641 ccgtggaccc aactgtggat gggggcgcac aggtgcaaca ggtggtcaac attgagtgta
     2701 tatctgattt cacagaggca cctgtcctca acatccagtt caggtatggt ggtaccttcc
     2761 agaatgtgtc tgttaagctt cccatcactc tcaacaaatt tttccagccc acagaaatgg
     2821 cttctcagga tttctttcaa cgttggaagc agttgagcaa tccacagcaa gaagtgcaga
     2881 atatcttcaa agcaaagcat ccgatggaca cagaaatcac taaagcgaag attattggat
     2941 ttggttctgc gctcctggaa gaagttgatc caaaccctgc aaattttgtg ggtgctggca
     3001 taatacatac caaaaccacc cagatcggct gcttgttgcg cctggagcca aacctgcaag
     3061 ctcagatgta cagactcacc ttgcgtacca gcaaagacac cgtctctcag agactatgtg
     3121 aattgctgtc ggaacagttc taatccacag accagaagat caggctcttt gtttgtgcgt
     3181 ctctctcgtc tctctcgttt gtctttgtac cacactgcag ataaacaccc cttgtctgaa
     3241 aactgccatt caaggcacct ccagtcctac acctacagcc agcccctggg tgtggaggga
     3301 atgcaggaca cagtttgaga agggctgcag caggcctgcc ccgtcaaaga agggtgcctg
     3361 ggcctgggaa atcaaggcag tcctgtggtt caacctacaa attaaaggga aattagaaat
     3421 ttgaacgaaa gtggaaattt tgttcaaatt ttattaaaat gccactggtt caatctcaga
     3481 atccagaaat agcgccatgt gcttataggg ttaacacagg gctgtgtgac catgctggat
     3541 ggtgagggca gtggcttaga ggtgtgtgac ctcaagggcc gggcagtgtc catggagttt
     3601 gctgcagcac tgcctgacgg tgctgaagtg cttgtgctta taactgttgg caaactccat
     3661 gcccactcgt ggcagggccc tgtgcctaac aagccagtgt tcttgaaggg acagtctgaa
     3721 catttcacca cttttttgag atcctagttt tgcagcatgg tgggcaaagg gcttcctctt
     3781 gactttggaa gacatggatg tcacccatct tttgttttta tgaatgtact gtccctatgg
     3841 taccttctgg ggacctgaag gctatgtggg tggggtgatg aggtaatgac tgtgagacac
     3901 gcttctctcc agagggtctt ggttggtgcc cagtgctctg tcctcacttc tgtgaagccc
     3961 ttgtggttgg gtgggaaaga gagacctaaa tgtggcaatg gagtgacagg ctggagcgag
     4021 aatggcagcc caggcaggtg ctgcactaag gatgcactgg gcttcctagc tcacgggcca
     4081 gttaaccctt tgtgggcatt ggactgtatg tacagcccat caggggaaga gcataggcca
     4141 catcagcagc tcaggcttgg gaccttgcac tctgtcttga ggtgatgccc aggactgcta
     4201 cagactcagc tgtatagggt cagcggtact tacacagcag tgttgatgtc ccttgcccac
     4261 tgcagcacta ggggtggtca cttaaatgag gatgtttttt gcctcagcct caggctgcta
     4321 gcctgtcatg gtgggtttga gggctgcagc agggctccag cctactcagg ctcccgtagc
     4381 cccactctgt ccagcccagg cagttagtca gaacaaccaa cacctgtgtg ctgatcagtg
     4441 cattccacaa agcccttggt ctgcctgtca tgttgtgacc cacgcctgcc atggcacagg
     4501 cttcttctgt tccagatgga tgacctagct gtggtcacag tgagcctccc aagtcccctt
     4561 gctctagtag ctggacagtg tggctgtcca ttatgtacag tccacgcact attgcatgga
     4621 ccgtgtggat agctcaacct gtgtaccatg tgctgcccag tgatggtgtc tcgatcagta
     4681 acgtcccagc acacggaagc tgctggggca taggcccgcc ctccatgact accgggcctc
     4741 cattagtcca gtgtgcttgt tctcagagaa aaaaaaaaaa taaatgctag gacaggaaac
     4801 tggaa
//
LOCUS       NM_053549               1850 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus vascular endothelial growth factor B (Vegfb),
            transcript variant 3, mRNA.
ACCESSION   NM_053549 XM_342006
VERSION     NM_053549.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Tu,S., Wang,X.Y., Zeng,L.X., Shen,Z.J. and Zhang,Z.H.
  TITLE     LncRNA TINCR improves cardiac hypertrophy by regulating the
            miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway
  JOURNAL   Lab Invest 102 (3), 253-262 (2022)
   PUBMED   34732848
  REMARK    GeneRIF: LncRNA TINCR improves cardiac hypertrophy by regulating
            the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Shang,R., Lal,N., Lee,C.S., Zhai,Y., Puri,K., Seira,O.,
            Boushel,R.C., Sultan,I., Rasanen,M., Alitalo,K., Hussein,B. and
            Rodrigues,B.
  TITLE     Cardiac-specific VEGFB overexpression reduces lipoprotein lipase
            activity and improves insulin action in rat heart
  JOURNAL   Am J Physiol Endocrinol Metab 321 (6), E753-E765 (2021)
   PUBMED   34747201
  REMARK    GeneRIF: Cardiac-specific VEGFB overexpression reduces lipoprotein
            lipase activity and improves insulin action in rat heart.
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Lal,N., Chiu,A.P., Wang,F., Zhang,D., Jia,J., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     Loss of VEGFB and its signaling in the diabetic heart is associated
            with increased cell death signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (6), H1163-H1175 (2017)
   PUBMED   28314760
  REMARK    GeneRIF: Loss of VEGFB and its downstream signaling is an early
            event following hyperglycemia, is sustained with disease
            progression, and could explain diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Monastero,R., Garcia-Serrano,S., Lago-Sampedro,A.,
            Rodriguez-Pacheco,F., Colomo,N., Morcillo,S., Martin-Nunez,G.M.,
            Gomez-Zumaquero,J.M., Garcia-Fuentes,E., Soriguer,F.,
            Rojo-Martinez,G. and Garcia-Escobar,E.
  TITLE     Methylation patterns of Vegfb promoter are associated with gene and
            protein expression levels: the effects of dietary fatty acids
  JOURNAL   Eur J Nutr 56 (2), 715-726 (2017)
   PUBMED   26707994
  REMARK    GeneRIF: Data suggest that dietary fatty acids create
            epigenetic/nutrigenomic changes in methylation levels of CpG island
            at Vegfb promoter and changes in Vegfb expression in white
            adipocytes in vivo and in vitro, with particular up-regulation of
            DNA methylation by linoleic acid; Vegfb promoter methylation levels
            are closely related to Vegfb gene expression in visceral and
            subcutaneous adipose tissue.
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Nag,S., Eskandarian,M.R., Davis,J. and Eubanks,J.H.
  TITLE     Differential expression of vascular endothelial growth factor-A
            (VEGF-A) and VEGF-B after brain injury
  JOURNAL   J Neuropathol Exp Neurol 61 (9), 778-788 (2002)
   PUBMED   12230324
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Ikuta,T., Ariga,H. and Matsumoto,K.
  TITLE     Extracellular matrix tenascin-X in combination with vascular
            endothelial growth factor B enhances endothelial cell proliferation
  JOURNAL   Genes Cells 5 (11), 913-927 (2000)
   PUBMED   11122379
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Bellomo,D., Headrick,J.P., Silins,G.U., Paterson,C.A., Thomas,P.S.,
            Gartside,M., Mould,A., Cahill,M.M., Tonks,I.D., Grimmond,S.M.,
            Townson,S., Wells,C., Little,M., Cummings,M.C., Hayward,N.K. and
            Kay,G.F.
  TITLE     Mice lacking the vascular endothelial growth factor-B gene (Vegfb)
            have smaller hearts, dysfunctional coronary vasculature, and
            impaired recovery from cardiac ischemia
  JOURNAL   Circ Res 86 (2), E29-E35 (2000)
   PUBMED   10666423
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_053549.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076395.1, SRR21887622.4094863.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000001.1  213606838-213607199 c
            363-405             JAXUCZ010000001.1  213606264-213606306 c
            406-602             JAXUCZ010000001.1  213605781-213605977 c
            603-676             JAXUCZ010000001.1  213605515-213605588 c
            677-712             JAXUCZ010000001.1  213605110-213605145 c
            713-847             JAXUCZ010000001.1  213604668-213604802 c
            848-1850            JAXUCZ010000001.1  213603513-213604515 c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1850
                     /gene="Vegfb"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     exon            1..362
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..863
                     /gene="Vegfb"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; VRF; VEGF-B; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B isoform 3
                     precursor"
                     /protein_id="NP_446001.1"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
                     /translation="MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYAR
                     ATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQIL
                     MIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDSPRTLCPRCTQRRQRPDPRTCRCR
                     CRRRRFLHCQGRGLELNPDTCRSSET"
     sig_peptide     303..359
                     /gene="Vegfb"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     exon            363..405
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            406..602
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            603..676
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            677..712
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            713..847
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1850
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgtccg ccagccccgg ccaggccccc tgccaccccc gccgtccccg ctgcccgccg
       61 tcccggccac caccaccaac acaggccgcc tgcctgtctc gttccttctg ccgccgctga
      121 ggcgctacgt tgcgctgcct gcgcccaggg ctcgggaggg ggccgcggag gagccgcccc
      181 ccgcgcccgg cccggggtcc ccacacccgg gcccgcgcca tgggactctg gctgccgccg
      241 ccccccgcgc cgccgggcta gggcaatgcg gtcgcccccg gcgctcggcc cccgcgggca
      301 ccatgagccc cctgctccgt cgcttgctgc ttgttgcgct gctgcagctg gcctgtaccc
      361 aggcccctgt gtcccagttt gatggcccca gccaccagaa gaaagtggtg tcatggatag
      421 atgtttatgc acgtgccaca tgccagccca gggaggtggt ggtacctctg agcatggaac
      481 tcatgggtaa tgtggtcaaa caactcgtgc ccagctgtgt gactgtgcag cgctgtggtg
      541 gctgctgtcc tgacgatggc ctggagtgtg tgcccattgg gcaacaccaa gtccgaatgc
      601 agatcctcat gatccagtac ccgagcagtc agctggggga gatgtccctg gaagaacaca
      661 gccaatgtga atgcagacca aaaagaaagg agagtgctgt gaagccagac agccccagga
      721 ccctctgccc acgctgcacc cagcgccgtc agcgccctga tccccggacc tgccgttgcc
      781 gctgcagacg ccgccgcttc ctccattgcc aagggcgggg cttagagctc aacccagata
      841 cctgcagatc atcagaaact tagctcaaga ctagatgcac aaatcagatg gtgagagaga
      901 tggtgtcacc accaatagaa gatgctaagc tctatgacag ggacaacgat ctaatctaag
      961 ccatcaacca tctcctggag gggaactcaa gaagactttt tccacgggct ttacacgata
     1021 gatatttgct ccattctgta ggctctgaga gagcagagat gtatgagaga gagcctcgaa
     1081 tacttaagta gcccttctct gttccatagt gaggccctgg gatgatttat gggccaggcc
     1141 ctggcggctt ctagagagta tcaaataaaa cagggttcca aaaaggaaat gcatcaagaa
     1201 ggctgggcct ggacatggtg gtacatatgg ggagttttgg caatacagag agagtttgaa
     1261 gccagcctgg gctatatgga accttgttta aaagcaaaac ccacagaaga caaaaaataa
     1321 ctgttgcttt ggaatggcag tgcacacctg taactccagc tctcaggagg cagaggcagg
     1381 aggatacgat tttgagaaca agctgggctg tagagcaaag tgatctcaac aaacagcaag
     1441 aataaagagg ggccgggtgt gtagctcagc cggtagagtg cttgcccagc attcaagaaa
     1501 ccatctgtaa tgggatccga tgccctcttc tggtgtgtct gaagacagct acagtgtact
     1561 catatataat acataaataa atctttaaaa aaaagccttc agtttgatct tcaccaaatg
     1621 gaacaaggca tgacagcact caaaggttca gggtcgggct ggagagatgg ctcagcggtt
     1681 aagagcaccc gactactctt ccagaggtcc tgagttcaat tcccagcaac cacatggtgg
     1741 ctcacaacca tctgtaaaga gatctgatgc tctcttctgg tgtatctgaa aacatctaca
     1801 gtgtacttat atataataaa tgaataaatc tttaaaaaaa aaaaaaaaaa
//
LOCUS       NM_001438413            4557 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus myosin IH (Myo1h), mRNA.
ACCESSION   NM_001438413
VERSION     NM_001438413.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4557)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000012.1  47984225-47984355   c
            132-293             JAXUCZ010000012.1  47960340-47960501   c
            294-409             JAXUCZ010000012.1  47958199-47958314   c
            410-608             JAXUCZ010000012.1  47955760-47955958   c
            609-689             JAXUCZ010000012.1  47954639-47954719   c
            690-869             JAXUCZ010000012.1  47950219-47950398   c
            870-968             JAXUCZ010000012.1  47947056-47947154   c
            969-1082            JAXUCZ010000012.1  47944944-47945057   c
            1083-1154           JAXUCZ010000012.1  47944497-47944568   c
            1155-1274           JAXUCZ010000012.1  47943579-47943698   c
            1275-1342           JAXUCZ010000012.1  47941403-47941470   c
            1343-1448           JAXUCZ010000012.1  47940083-47940188   c
            1449-1529           JAXUCZ010000012.1  47937943-47938023   c
            1530-1621           JAXUCZ010000012.1  47936504-47936595   c
            1622-1716           JAXUCZ010000012.1  47931088-47931182   c
            1717-1763           JAXUCZ010000012.1  47927636-47927682   c
            1764-1844           JAXUCZ010000012.1  47925810-47925890   c
            1845-1950           JAXUCZ010000012.1  47924774-47924879   c
            1951-2068           JAXUCZ010000012.1  47923539-47923656   c
            2069-2182           JAXUCZ010000012.1  47920172-47920285   c
            2183-2259           JAXUCZ010000012.1  47918705-47918781   c
            2260-2328           JAXUCZ010000012.1  47917436-47917504   c
            2329-2413           JAXUCZ010000012.1  47915843-47915927   c
            2414-2573           JAXUCZ010000012.1  47914792-47914951   c
            2574-2657           JAXUCZ010000012.1  47913794-47913877   c
            2658-2751           JAXUCZ010000012.1  47913141-47913234   c
            2752-2807           JAXUCZ010000012.1  47912980-47913035   c
            2808-2943           JAXUCZ010000012.1  47912266-47912401   c
            2944-3014           JAXUCZ010000012.1  47911843-47911913   c
            3015-3112           JAXUCZ010000012.1  47911628-47911725   c
            3113-3212           JAXUCZ010000012.1  47910732-47910831   c
            3213-4557           JAXUCZ010000012.1  47908639-47909983   c
FEATURES             Location/Qualifiers
     source          1..4557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4557
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="myosin IH"
                     /db_xref="GeneID:687866"
                     /db_xref="RGD:1596237"
     exon            1..131
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="upstream in-frame stop codon"
     CDS             120..3236
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="unconventional myosin-Ih; unconventional
                     myosin-Ih-like"
                     /codon_start=1
                     /product="myosin IH"
                     /protein_id="NP_001425342.1"
                     /db_xref="GeneID:687866"
                     /db_xref="RGD:1596237"
                     /translation="MGSKKEEVRRKHIRLHMEGALTARDKVGVQDFVLLDAYTSESAF
                     LENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTSSQMELYQGVNFFELPPHVYAIAD
                     NAYRMMCSELNNHFILISGESGAGKTEASKKILQYLAVTCPMTESLQIARDRLLLSIP
                     VLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQNHGERNF
                     HIFYQLLAGGKSERLASLGLERDPQLYKFLSQGHCARESPSNDRSDWETVYSAFSVIG
                     FTEADLENLFGIIASVLHLGNICFKGDKQGCASIPDTHEIKWIAKLLGVCPAVLLEAL
                     THRKIEAKTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTQKTV
                     IGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWEPVQYF
                     NNKIICDLVEERHRGIISILDEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPK
                     GRKRIGWLEFCLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCSSKNSILRECFLVAE
                     LENRKRPPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNERKEPSKFDDFLISHQIKY
                     LGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPGEGVERLIKYIGYQPQ
                     DYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVSRIQATYKGCLGRREYVRKRQAATKL
                     EAHWRGVLARKEIKRRKWAVQIIRRFIKGFINRDKPLCPDNEEFLLLVRKNYILNLRY
                     HVPKNVLDKSWLRPPGILENASNLLRRMCTRNLVRKYCRGISAERKAMMQQKAVTSGL
                     FRGKKEGYAESLSQPFASSRLDEGKINPKVLQLLGSEKIQYGVPVIKYDRKGFKARQR
                     QLLLTLRSAYLVEFSKIKQKMEYSALRGVSTSSLRDGILVIHVSPADKQQKGDTILQC
                     EHIFEVATKLAMLIKREHVVRVVQGSLQFCVSPGREGTIVFETGEEDQVYKDKNGQLR
                     VVSAGKKT"
     misc_feature    243..2201
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="class I myosin, motor domain; Region: MYSc_Myo1;
                     cd01378"
                     /db_xref="CDD:276829"
     misc_feature    243..2201
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="class I myosin, motor domain; Region: MYSc_Myo1;
                     cd01378"
                     /db_xref="CDD:276829"
     misc_feature    order(324..335,348..350,480..503,621..653,1308..1325)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(324..335,348..350,480..503,621..653,1308..1325)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(324..335,348..350)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(324..335,348..350)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="purine-binding loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    480..503
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="P-loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    480..503
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="P-loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    621..653
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="switch I region; other site"
                     /db_xref="CDD:276829"
     misc_feature    621..653
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="switch I region; other site"
                     /db_xref="CDD:276829"
     misc_feature    1308..1325
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="switch II region; other site"
                     /db_xref="CDD:276829"
     misc_feature    1308..1325
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="switch II region; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(1395..1430,1437..1460,1464..1466)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="relay loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(1395..1430,1437..1460,1464..1466)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="relay loop; other site"
                     /db_xref="CDD:276829"
     misc_feature    1995..2027
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276829"
     misc_feature    1995..2027
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(2031..2111,2160..2201)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276829"
     misc_feature    order(2031..2111,2160..2201)
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:276829"
     misc_feature    <2187..>2423
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <2187..>2423
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    2187..2261
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    2187..2261
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    2298..2390
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    2298..2390
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    2331..2387
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    2331..2387
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    2667..3212
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="Unconventional myosin tail, actin- and
                     lipid-binding; Region: Myosin_TH1; pfam06017"
                     /db_xref="CDD:461801"
     misc_feature    2667..3212
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /note="Unconventional myosin tail, actin- and
                     lipid-binding; Region: Myosin_TH1; pfam06017"
                     /db_xref="CDD:461801"
     exon            132..293
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..409
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..608
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..689
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..869
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..968
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1082
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1154
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1274
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1342
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1448
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1529
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1621
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1716
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1763
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1844
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1950
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2068
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2182
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2259
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2328
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2413
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2573
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2657
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2751
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2807
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2943
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3014
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3112
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3212
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..4557
                     /gene="Myo1h"
                     /gene_synonym="AABR07036550.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatctcca aggtccttga tgcggagtgt cacaggttgt aggatcgcca ggcacttcaa
       61 ggcaagctct gcccagctca agcagagggg tggtaacaac cgctctcccc acaagcacca
      121 tgggatccaa gaaagaagag gtgaggagga aacacatccg cctgcacatg gaaggggcgc
      181 tcaccgccag ggacaaggtc ggagtgcagg actttgtgct attggacgcc tacaccagcg
      241 aatccgcctt cctggagaat cttcgcaagc gtttcagaga gaacctcatc tatacgtata
      301 tcgggacgct gctcgtgtct gtgaatccgt accaggagct gggaatctat acctccagcc
      361 agatggagct ttatcaaggg gtcaatttct tcgaactacc accacatgtc tacgccatcg
      421 ccgacaacgc ttaccgcatg atgtgctcag agctcaacaa ccactttatc ctcatctctg
      481 gagagagcgg agctgggaag acagaggcct ccaagaagat cctccagtac ttggcagtga
      541 cctgtcccat gacggagtcg ctccaaatag cccgggacag gttgctgctc tccatcccag
      601 tcctggaggc tttcggaaat gccaagaccc tccgcaatga caactccagc agatttggaa
      661 aatacatgga catacagttc gacttccagg gtgttcctgt gggcggccac atcatcagtt
      721 acttgattga aaaatcccga gtcgtctatc agaaccacgg agagcggaat ttccacatct
      781 tctaccagct gctggcgggt ggcaaatcgg agcgcctcgc ttccctggga cttgagcgag
      841 accctcagct gtacaagttc ctgtcacagg gtcattgtgc cagagagtcc cccagcaatg
      901 acaggagcga ctgggaaacc gtgtacagtg ccttctcggt cattggtttt actgaagccg
      961 accttgagaa cctctttggg atcatcgcta gtgtcctaca cctgggcaac atctgtttca
     1021 agggggacaa acaaggctgt gctagcatcc cggacaccca cgaaatcaag tggatcgcca
     1081 agctcctggg agtctgccca gctgttcttc tggaagcgct cactcacaga aagatcgaag
     1141 ccaaaacaga ggaggtgata tgcccgttga cagtagaact ctctgtttac gccagagacg
     1201 ccatggcaaa ggcagtttat gggcggacat ttacctggct ggtcaataaa atcaattctt
     1261 ccttagttaa caaggatttc acccaaaaga ctgtgattgg gttgttggac atctacggct
     1321 ttgaagtttt cgacaagaat ggttttgaac agttctgtat caattactgc aatgagaaac
     1381 tacagcagct gctgatagag aggacgctga aggcggagca ggccgagtat gaatctgaag
     1441 gcatcgagtg ggagcctgtc cagtacttca acaacaagat catctgtgat ttggtagaag
     1501 agagacacag agggatcatc tctattctgg atgaagaatg catccgtccc ggccccgcaa
     1561 ccgacttgag tttcctggag aagctggagg agaaagttgg caaacacgcg cacttccaaa
     1621 cccggaagct ggctggtcca aagggccgga agaggatcgg gtggctggaa ttctgcctcc
     1681 tacattacgc aggagaggtt acctactgca ccaaaggatt cttggagaaa aacaatgacc
     1741 tgctttacag acacctgaag gaggtgctgt gcagctccaa gaatagcatc ttgagggagt
     1801 gtttcctggt ggcggagctt gaaaaccgga agcgaccacc cacggttggg actcagttta
     1861 agaacagcct gagcagcctc ctggaaattc tcatctccaa ggagccttcc tacatccgct
     1921 gcatcaagcc caatgaaagg aaggaaccca gcaagtttga cgacttcctc attagccacc
     1981 agatcaagta cctggggctc atggagcacc tgcgtgtgcg gcgggcaggc ttcgcctaca
     2041 ggcgcaagta tgagcatttc ctgcaaaggt acaagtcatt gtgcccagac acctggccgc
     2101 actggcatgg accgccagga gagggcgttg agcggctgat caagtatatc ggttaccaac
     2161 ctcaggacta caagttagga aaaaccaaaa tattcattcg cttcccgaga accctgtttg
     2221 ctactgaaga tgcctttgaa ttcagtaaac atcaactagt gtcgagaatc caggccacat
     2281 acaaaggctg cctaggaaga cgggaatacg tgaggaagag acaagcagcc accaagttag
     2341 aagcccactg gcgtggagtc ctggctcgga aggagatcaa gaggaggaag tgggcggtgc
     2401 agattatacg gaggttcatc aagggtttca tcaaccgtga caaacccctt tgccctgaca
     2461 acgaggagtt cttactgctc gtgaggaaga attacatcct gaatcttcgc taccacgtgc
     2521 caaagaacgt tctggacaag agctggctga ggcctccggg catcctggag aacgcttcca
     2581 atctgcttag aaggatgtgc acgaggaacc ttgttcggaa gtactgccgt ggaatctcag
     2641 ccgagaggaa agccatgatg cagcaaaagg cagtgaccag tgggctattc cggggaaaga
     2701 aggagggcta cgcagagagc ttaagccaac cctttgccag cagcaggctg gatgaaggca
     2761 agataaaccc caaagtgctt caactgctgg gcagcgagaa gatccagtac ggtgtcccgg
     2821 tcatcaagta tgacagaaaa ggcttcaagg cacgacagcg gcaactcctc ctcacgctga
     2881 ggtcagcgta cctggtggag ttttccaaaa tcaagcagaa gatggagtac tcagctctga
     2941 gaggtgtctc caccagcagc cttagggatg gaatcctagt cattcacgtc tcaccagcag
     3001 acaaacagca aaagggggat accatcctgc agtgtgaaca catatttgag gtggccacca
     3061 agctcgccat gctgattaag agggagcatg tcgtccgggt tgtccaagga agtttacagt
     3121 tctgtgtcag tcccgggaga gaaggcacga tagtttttga gactggagag gaagaccaag
     3181 tctataagga taaaaacgga cagttaagag tggtgtcggc ggggaagaag acctgacaga
     3241 ggatggccct ccacggtcac tactgttcca gctgaggcac gttacggcac aagcgccgac
     3301 ctgctccagt tacccatgct cagggccagt gcagcagctc ctggaggatg gctgcagcaa
     3361 ggagcctgtg ccacggcaaa gccaggtctc aggccgcact gcatccaaat gcttcctggg
     3421 agccaaccta gagtcacccc gtccctggca gaacccattt taggtgcaca ccagaggtgg
     3481 tcacagggcg gacggcaggc tgctaagaca caggagtagg ggaaccttgt caagtcgccc
     3541 aacttgaatt ctgctgtaca tgacacgcat gctgccaggg actgggcgaa gctcccagat
     3601 cccagagagg gagtgggggt cctgacccca atctgctaac accagccaat tcactccatt
     3661 gcttcacaag cccctcagct tcctcttagt gcttaagccc tacagagaag gactcgactc
     3721 tgaggtggcc tggccctcgc tgcacgccag cagccaggct gagtcagaca ttcttgaaaa
     3781 gaccacaagg cggaggagga gaagcagagt ttaacgttta ttttacatgt gtccgcagac
     3841 gcttgtacaa gagtgagcac ttctaaaact cccagcatgg ttttatagtg cagaggcagg
     3901 aaggtagtga tgtgattctg tgaccaggga ctgaatggag ccctctggcc tgcacgcact
     3961 ctggggaggg ctgaacacca acactgagaa gcaggtatgg gacgtggccc ttgagtggga
     4021 tctgagcctc cagagaggtc aaacagccca tcttccacag caggaacagg aagctgtgtc
     4081 agacctgctg gggtgcagcc cgccacccga cagtgaattg tgagccctta gcatgcaaag
     4141 ttcactcttc tcacagcgac tcactagatg gtgacctgga aacgctgact accgcccttc
     4201 acgccagcgg tgggacctga ggcagagctt tggagatggg cgctggttgg gcctggctgg
     4261 acacagccac cagtggtttc aggcaccatg gaatgttcgc taggtctgtt cctacccctg
     4321 ggagtggagg cacaaagcta caggcacaag gtttgaggct agaggaaggt agagagagct
     4381 gccaaaccag taacctaagg ccagaggccc aggcaagtca gattgtgctg ctcggctgtt
     4441 ctgcacatga acttaaaggg tggatcatgg cttttccatt cctacagaag acaccaggac
     4501 tgacattcag tttagctgac gttgaagaca aacagtataa aaatgtagga aacatgg
//
LOCUS       NM_032616               2073 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus lipolysis stimulated lipoprotein receptor (Lsr),
            transcript variant 2, mRNA.
ACCESSION   NM_032616
VERSION     NM_032616.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2073)
  AUTHORS   Wang,J., Qin,M., Wu,Q., Yang,H., Wei,B., Xie,J., Qin,Y., Liang,Z.
            and Huang,J.
  TITLE     Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight
            Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis
  JOURNAL   Biomed Res Int 2022, 4234186 (2022)
   PUBMED   35463981
  REMARK    GeneRIF: Effects of Lipolysis-Stimulated Lipoprotein Receptor on
            Tight Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2073)
  AUTHORS   Sohet,F., Lin,C., Munji,R.N., Lee,S.Y., Ruderisch,N., Soung,A.,
            Arnold,T.D., Derugin,N., Vexler,Z.S., Yen,F.T. and Daneman,R.
  TITLE     LSR/angulin-1 is a tricellular tight junction protein involved in
            blood-brain barrier formation
  JOURNAL   J Cell Biol 208 (6), 703-711 (2015)
   PUBMED   25753034
REFERENCE   3  (bases 1 to 2073)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   4  (bases 1 to 2073)
  AUTHORS   Furuse,M., Oda,Y., Higashi,T., Iwamoto,N. and Masuda,S.
  TITLE     Lipolysis-stimulated lipoprotein receptor: a novel membrane protein
            of tricellular tight junctions
  JOURNAL   Ann N Y Acad Sci 1257, 54-58 (2012)
   PUBMED   22671589
REFERENCE   5  (bases 1 to 2073)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   6  (bases 1 to 2073)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 2073)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 2073)
  AUTHORS   Yagil,C., Hubner,N., Monti,J., Schulz,H., Sapojnikov,M., Luft,F.C.,
            Ganten,D. and Yagil,Y.
  TITLE     Identification of hypertension-related genes through an integrated
            genomic-transcriptomic approach
  JOURNAL   Circ Res 96 (6), 617-625 (2005)
   PUBMED   15731461
REFERENCE   9  (bases 1 to 2073)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
REFERENCE   10 (bases 1 to 2073)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced NM_032616.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119667.1, FO794106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000001.1  95329045-95329339   c
            296-640             JAXUCZ010000001.1  95327858-95328202   c
            641-760             JAXUCZ010000001.1  95321993-95322112   c
            761-817             JAXUCZ010000001.1  95318934-95318990   c
            818-964             JAXUCZ010000001.1  95318220-95318366   c
            965-1126            JAXUCZ010000001.1  95315234-95315395   c
            1127-1186           JAXUCZ010000001.1  95315054-95315113   c
            1187-1318           JAXUCZ010000001.1  95314834-95314965   c
            1319-1947           JAXUCZ010000001.1  95314043-95314671   c
            1948-2073           JAXUCZ010000001.1  95313830-95313955   c
FEATURES             Location/Qualifiers
     source          1..2073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2073
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
     exon            1..295
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="upstream in-frame stop codon"
     CDS             202..1983
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lipolysis-stimulated remnant receptor;
                     liver-specific bHLH-Zip transcription factor 7;
                     lipolysis-stimulated receptor"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 2 precursor"
                     /protein_id="NP_116005.1"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
                     /translation="MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDP
                     YHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASL
                     LLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYT
                     HLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGY
                     RIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRA
                     PALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTE
                     SGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPR
                     SRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPP
                     YSETDSQASRERRLKKNLALSRESLVV"
     sig_peptide     202..306
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1)"
     mat_peptide     307..1980
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /product="Lipolysis-stimulated lipoprotein receptor.
                     /id=PRO_0000245310"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1)"
     misc_feature    820..882
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1);
                     transmembrane region"
     misc_feature    1048..1050
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1123..1125
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1141..1143
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1195..1197
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1324..1935
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU74.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1324..1326
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1336..1338
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1387..1389
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1420..1422
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1429..1431
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1507..1509
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1612..1614
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1618..1620
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1633..1635
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1924..1926
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1960..1962
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     misc_feature    1969..1971
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86X29; propagated from
                     UniProtKB/Swiss-Prot (Q9WU74.1); phosphorylation site"
     exon            296..640
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            641..760
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            761..817
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            818..964
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1126
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1186
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1318
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1947
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2073
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtcccc gggaagccga aggcatgagc ttcgcccaag ttctttttat gggttagaac
       61 tcctccagag cggggaaaaa gaacttggaa taggggcggg acggagcacg cacccttctc
      121 cgccttggtt ctcgccgcgc cccctactct cgggatactt gggaggggac gcgcgggcac
      181 cgtcgctgct agacggccgc gatggcgccg gcggccggcg cgtgtgctgg ggcgcctgac
      241 tcccacccag ctaccgtggt cttcgtgtgt ctctttctca tcattttctg cccagaccct
      301 gccagtgcca tccaggtgac tgtgtctgac ccctaccacg tagtgatcct gttccagcca
      361 gtgaccctgc cctgcaccta tcagatgagc aacactctca cagtccccat cgtgatctgg
      421 aagtacaagt cattctgccg ggaccgtatt gccgatgcct tctctcctgc cagtgtggac
      481 aaccagctaa atgcccagtt ggcagctggc aaccccggct acaaccccta tgtggagtgc
      541 caggacagtg tacgcactgt cagggtggtg gccaccaaac agggcaatgc ggtgaccctg
      601 ggagactact accaaggcag gaggatcacc ataacaggaa atgctgacct gaccttcgag
      661 cagacagcct ggggagacag tggagtgtat tactgctctg tggtctcggc ccaagatctg
      721 gatggaaaca acgaggcgta cgcagagctc atcgtccttg gcaggacctc agaggcccct
      781 gagctcctac ctggttttcg ggcggggccc ttggaagatt ggctctttgt ggtcgtggtc
      841 tgcctggcga gcctcctcct cttcctcctc ctgggcatct gctggtgcca gtgctgtcct
      901 cacacctgct gctgctatgt ccgatgtccc tgctgcccag acaagtgctg ttgccctgag
      961 gctctttatg ctgctggcaa agcagccacc tcaggtgtcc cgagcatcta tgcccccagc
     1021 atctataccc acctctcacc tgccaagacc ccaccacctc cgcctgccat gattcccatg
     1081 ggccctccct atgggtaccc tggagacttt gacagacata gctcagttgg tggccacagc
     1141 tcccaagtac ccctgctgcg tgacgtggat ggcagtgtat cttcagaagt acgaagtggc
     1201 tacaggatcc aggctaacca gcaagatgac tccatgaggg tcctatacta tatggagaaa
     1261 gagctagcca actttgaccc ttcccgacct ggccctccca atggcagagt ggaacgggcc
     1321 atgagtgaag taacctccct ccatgaagat gactggcgat cgaggccttc cagggctcct
     1381 gccctcaccc ccatcaggga tgaggagtgg aatcgccact ccccacagag tcccagaaca
     1441 tgggagcagg aaccccttca agaacaacca aggggtggtt gggggtctgg acggcctcgg
     1501 gcccgctctg tggatgctct agatgatatc aaccggcctg gctccactga atcaggacgg
     1561 tcttctcccc caagtagtgg acggagagga cgagcctatg cacctccaag aagtcgcagc
     1621 cgggatgacc tctatgaccc ggacgatcct agggacttgc cacattcccg agatccccac
     1681 tattatgacg acatcaggtc tagagatcca cgtgctgacc ccagatcccg tcagcgatcc
     1741 cgagatcctc gggatgctgg cttcaggtca agggaccctc agtatgatgg gcgactatta
     1801 gaagaggctt taaagaaaaa ggggtcgggc gagagaagga gggtttacag ggaggaagaa
     1861 gaggaagagg agggccaata ccccccagca cctccacctt actcagagac tgactcgcag
     1921 gcctcacggg agaggaggct gaaaaagaat ttggccctga gtcgggaaag tttagtcgtc
     1981 tgatccacgt tttgtatgta gcttttgtac tttttttttt aattggaatc aatattgatg
     2041 aaacttcaag cctaataaaa tgtctaatca caa
//
LOCUS       NM_001438372            1869 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus lipolysis stimulated lipoprotein receptor (Lsr),
            transcript variant 3, mRNA.
ACCESSION   NM_001438372 XM_006228845
VERSION     NM_001438372.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   Wang,J., Qin,M., Wu,Q., Yang,H., Wei,B., Xie,J., Qin,Y., Liang,Z.
            and Huang,J.
  TITLE     Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight
            Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis
  JOURNAL   Biomed Res Int 2022, 4234186 (2022)
   PUBMED   35463981
  REMARK    GeneRIF: Effects of Lipolysis-Stimulated Lipoprotein Receptor on
            Tight Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Sohet,F., Lin,C., Munji,R.N., Lee,S.Y., Ruderisch,N., Soung,A.,
            Arnold,T.D., Derugin,N., Vexler,Z.S., Yen,F.T. and Daneman,R.
  TITLE     LSR/angulin-1 is a tricellular tight junction protein involved in
            blood-brain barrier formation
  JOURNAL   J Cell Biol 208 (6), 703-711 (2015)
   PUBMED   25753034
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Furuse,M., Oda,Y., Higashi,T., Iwamoto,N. and Masuda,S.
  TITLE     Lipolysis-stimulated lipoprotein receptor: a novel membrane protein
            of tricellular tight junctions
  JOURNAL   Ann N Y Acad Sci 1257, 54-58 (2012)
   PUBMED   22671589
REFERENCE   5  (bases 1 to 1869)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   6  (bases 1 to 1869)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 1869)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 1869)
  AUTHORS   Yagil,C., Hubner,N., Monti,J., Schulz,H., Sapojnikov,M., Luft,F.C.,
            Ganten,D. and Yagil,Y.
  TITLE     Identification of hypertension-related genes through an integrated
            genomic-transcriptomic approach
  JOURNAL   Circ Res 96 (6), 617-625 (2005)
   PUBMED   15731461
REFERENCE   9  (bases 1 to 1869)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
REFERENCE   10 (bases 1 to 1869)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006228845.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119669.1, SRR26643288.1966.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000001.1  95329045-95329339   c
            296-640             JAXUCZ010000001.1  95327858-95328202   c
            641-760             JAXUCZ010000001.1  95321993-95322112   c
            761-922             JAXUCZ010000001.1  95315234-95315395   c
            923-982             JAXUCZ010000001.1  95315054-95315113   c
            983-1114            JAXUCZ010000001.1  95314834-95314965   c
            1115-1743           JAXUCZ010000001.1  95314043-95314671   c
            1744-1869           JAXUCZ010000001.1  95313830-95313955   c
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1869
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
     exon            1..295
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="upstream in-frame stop codon"
     CDS             202..1779
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; lipolysis-stimulated remnant receptor;
                     liver-specific bHLH-Zip transcription factor 7;
                     lipolysis-stimulated receptor"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 3 precursor"
                     /protein_id="NP_001425301.1"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
                     /translation="MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDP
                     YHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLVYAAGKAATSGVPSIYAPSIYTHLSPAKTPPP
                     PPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDS
                     MRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEE
                     WNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSG
                     RRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRD
                     AGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASR
                     ERRLKKNLALSRESLVV"
     sig_peptide     202..309
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     exon            296..640
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            641..760
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            761..922
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            923..982
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1114
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1743
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1869
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtcccc gggaagccga aggcatgagc ttcgcccaag ttctttttat gggttagaac
       61 tcctccagag cggggaaaaa gaacttggaa taggggcggg acggagcacg cacccttctc
      121 cgccttggtt ctcgccgcgc cccctactct cgggatactt gggaggggac gcgcgggcac
      181 cgtcgctgct agacggccgc gatggcgccg gcggccggcg cgtgtgctgg ggcgcctgac
      241 tcccacccag ctaccgtggt cttcgtgtgt ctctttctca tcattttctg cccagaccct
      301 gccagtgcca tccaggtgac tgtgtctgac ccctaccacg tagtgatcct gttccagcca
      361 gtgaccctgc cctgcaccta tcagatgagc aacactctca cagtccccat cgtgatctgg
      421 aagtacaagt cattctgccg ggaccgtatt gccgatgcct tctctcctgc cagtgtggac
      481 aaccagctaa atgcccagtt ggcagctggc aaccccggct acaaccccta tgtggagtgc
      541 caggacagtg tacgcactgt cagggtggtg gccaccaaac agggcaatgc ggtgaccctg
      601 ggagactact accaaggcag gaggatcacc ataacaggaa atgctgacct gaccttcgag
      661 cagacagcct ggggagacag tggagtgtat tactgctctg tggtctcggc ccaagatctg
      721 gatggaaaca acgaggcgta cgcagagctc atcgtccttg tttatgctgc tggcaaagca
      781 gccacctcag gtgtcccgag catctatgcc cccagcatct atacccacct ctcacctgcc
      841 aagaccccac cacctccgcc tgccatgatt cccatgggcc ctccctatgg gtaccctgga
      901 gactttgaca gacatagctc agttggtggc cacagctccc aagtacccct gctgcgtgac
      961 gtggatggca gtgtatcttc agaagtacga agtggctaca ggatccaggc taaccagcaa
     1021 gatgactcca tgagggtcct atactatatg gagaaagagc tagccaactt tgacccttcc
     1081 cgacctggcc ctcccaatgg cagagtggaa cgggccatga gtgaagtaac ctccctccat
     1141 gaagatgact ggcgatcgag gccttccagg gctcctgccc tcacccccat cagggatgag
     1201 gagtggaatc gccactcccc acagagtccc agaacatggg agcaggaacc ccttcaagaa
     1261 caaccaaggg gtggttgggg gtctggacgg cctcgggccc gctctgtgga tgctctagat
     1321 gatatcaacc ggcctggctc cactgaatca ggacggtctt ctcccccaag tagtggacgg
     1381 agaggacgag cctatgcacc tccaagaagt cgcagccggg atgacctcta tgacccggac
     1441 gatcctaggg acttgccaca ttcccgagat ccccactatt atgacgacat caggtctaga
     1501 gatccacgtg ctgaccccag atcccgtcag cgatcccgag atcctcggga tgctggcttc
     1561 aggtcaaggg accctcagta tgatgggcga ctattagaag aggctttaaa gaaaaagggg
     1621 tcgggcgaga gaaggagggt ttacagggag gaagaagagg aagaggaggg ccaatacccc
     1681 ccagcacctc caccttactc agagactgac tcgcaggcct cacgggagag gaggctgaaa
     1741 aagaatttgg ccctgagtcg ggaaagttta gtcgtctgat ccacgttttg tatgtagctt
     1801 ttgtactttt ttttttaatt ggaatcaata ttgatgaaac ttcaagccta ataaaatgtc
     1861 taatcacaa
//
LOCUS       NM_001438362            2480 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7),
            transcript variant 3, mRNA.
ACCESSION   NM_001438362 XM_039089500
VERSION     NM_001438362.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2480)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2480)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2480)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2480)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_039089500.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.4228.1,
                                           SRR26360186.345187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680426, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  208444568-208444623
            57-184              JAXUCZ010000001.1  208447533-208447660
            185-276             JAXUCZ010000001.1  208450390-208450481
            277-499             JAXUCZ010000001.1  208451583-208451805
            500-590             JAXUCZ010000001.1  208452757-208452847
            591-804             JAXUCZ010000001.1  208453456-208453669
            805-1009            JAXUCZ010000001.1  208455552-208455756
            1010-1141           JAXUCZ010000001.1  208457746-208457877
            1142-2480           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2480
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..56
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            57..184
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Dhcr7"
                     /note="upstream in-frame stop codon"
     exon            185..276
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1606
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_001425291.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     misc_feature    296..358
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    455..1603
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    455..1603
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    473..535
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    620..682
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    707..769
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    887..949
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    974..1036
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1094..1156
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1169..1231
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1436..1498
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     exon            277..499
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            500..590
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            591..804
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1009
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1141
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2480
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttag ggcgctgctg gagctcgtga atcaaccgcc cggatcccgc acgcagagtg
       61 ttactcagca tatgggcaag gattgatcag accttggggg acttctgaac ctggacattt
      121 tgagagccac ttttgagaaa gacaacatca ttctattgtg aaacctgtgg cccagaggtc
      181 aaagatcctg atggcttcaa agtcccagca caacgcttcc aaagccaaga atcacaacgt
      241 caaggctgaa tctcaaggac aatggggccg tgcctgggaa gtggactggt tctccctggt
      301 cagcgtcatt ttcctgctgc tcttcgcacc gttcattgtg tactacttca tcatggcatg
      361 tgaccagtac agctgctcgc tgactgcccc catattggac gtagctacag gccgtgcgag
      421 tctggcagac atctgggcca agacaccgcc tgtgacagct aaggctgccc aactgtatgc
      481 cttgtgggtc agcttccagg tgctgcttta ctcctggctt cctgacttct gccacagatt
      541 tctgccaggt tatgtgggag gcgtccaaga aggtgccata actccagcag ggattgtaaa
      601 taagtatgag gtgaatgggc tgcaagcctg gctcattacc cacttcctct ggtttgtgaa
      661 cgcttacctc ctatcctggt tctcccccac catcatcttt gacaactgga tcccgttgct
      721 atggtgtgcc aacatcctgg gctacgctgt gtccaccttt gcaatgatca aggggtacct
      781 gttccccacc agcgccgaag actgcaaatt cacaggcaat ttcttctaca actacatgat
      841 ggggattgag ttcaaccccc gcatcggaaa gtggtttgac ttcaagctgt tcttcaatgg
      901 gcgcccgggg attgtggcct ggactcttat caacctgtcc tttgctgcca agcagcagga
      961 gctttatggc catgtgacca actccatgat tttggtcaat gtcttacagg ccatctatgt
     1021 gttagacttc ttctggaacg aaacctggta cctgaagacc attgacatct gccatgacca
     1081 ctttggatgg tacctgggct ggggagattg cgtgtggctg ccctacctct acacactgca
     1141 gggcctgtac ttggtgtacc accctgtaca gctctccacc cccaacgcct tgggcgtcct
     1201 gctgctcggc ctggtgggtt actatatctt ccgaatgacc aaccatcaga aggacctgtt
     1261 ccgccggaca gatggacact gcctcatctg gggcaagaaa cccaaggcca tcgagtgctc
     1321 ctacacgtca gccgacgggc tgaagcaccg cagcaagctg ttggtttcag gcttctgggg
     1381 tgtggcccgc cacttcaact ataccggaga cctgatgggc agcctcgcct actgcctggc
     1441 ttgtggcggc ggccacctcc tcccctactt ctacatcatc tatatgacta tcctgcttac
     1501 ccaccgctgc ctccgtgatg agcaccgctg tgccaacaag tatggccgtg actgggagcg
     1561 ctacgtagcc gctgtgccct accgcctgct gcctgggatc ttctgagggc caccctggca
     1621 agcagaaaga ggcgtcattg aatgtgtgga gttgggtgca tgggggccag cgtccggctt
     1681 tcccctgcag gggcctcctt ggtttgctct tctggaggat ggagagccag gcgccccaca
     1741 gtgtctggct ggtggcagct agagctgagt tcacactgat gccccagcag aatgactggt
     1801 tctccctgtt cagcatcctg agggcagagg accttggccc tttcatgtct gttggaagcc
     1861 caccatctat gttgtctaga tagcttaggc ttaccaggtg tctcccagga ttgggccatc
     1921 ctggtaaact ggagacaatg taggatctaa agagtttggc aatgtcacct tcactcccac
     1981 ctgcaatggt gggctggacc cctttttctg tctgtagtgt gatcagcaga gggttcaggg
     2041 gccattgaag gaggaaggct ctttgtttag gttctttact gtttttaccc gaggaatgcc
     2101 aagcagcgga ctggaatatc ccactctgca catccctggc tgacttgata aagtctgtct
     2161 gacatatgag atggggttcc cagaactccc caagtacccc agctagcagc ttatccatct
     2221 cccctcttcc ggaaggtgct tcttgtttac ccctgagact tggctcagag gtgaacagac
     2281 ttggctctga caacccagaa tgtatcacca gttagtggcc tcagccacac cttccccaac
     2341 aggagaacca gcgttgggga aggaatccat tctcattagt gacactgccc cccaaaactc
     2401 agggttattt tgtaaaacta gataggctca tgttagcctt gcaagcggtt ctttgtatta
     2461 aatctgcctt gttaaatgag
//
LOCUS       NM_001438437            2106 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 7 member 9 (Slc7a9),
            transcript variant 1, mRNA.
ACCESSION   NM_001438437
VERSION     NM_001438437.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Shigeta,Y., Kanai,Y., Chairoungdua,A., Ahmed,N., Sakamoto,S.,
            Matsuo,H., Kim,D.K., Fujimura,M., Anzai,N., Mizoguchi,K., Ueda,T.,
            Akakura,K., Ichikawa,T., Ito,H. and Endou,H.
  TITLE     A novel missense mutation of SLC7A9 frequent in Japanese cystinuria
            cases affecting the C-terminus of the transporter
  JOURNAL   Kidney Int 69 (7), 1198-1206 (2006)
   PUBMED   16609684
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Kwak,J.O., Kim,H.W., Jung,S.M., Song,J.H., Hong,S.B., Oh,K.J.,
            Ko,C.B. and Cha,S.H.
  TITLE     Co-localization and interaction of b0,+-type amino acid transporter
            1 (BAT1) with caveolin-1 in rat kidney
  JOURNAL   J Nephrol 18 (6), 681-689 (2005)
   PUBMED   16358225
REFERENCE   3  (bases 1 to 2106)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 2106)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 2106)
  AUTHORS   Feliubadalo,L., Font,M., Purroy,J., Rousaud,F., Estivill,X.,
            Nunes,V., Golomb,E., Centola,M., Aksentijevich,I., Kreiss,Y.,
            Goldman,B., Pras,M., Kastner,D.L., Pras,E., Gasparini,P.,
            Bisceglia,L., Beccia,E., Gallucci,M., de Sanctis,L., Ponzone,A.,
            Rizzoni,G.F., Zelante,L., Bassi,M.T., George,A.L. Jr., Manzoni,M.,
            De Grandi,A., Riboni,M., Endsley,J.K., Ballabio,A., Borsani,G.,
            Reig,N., Fernandez,E., Estevez,R., Pineda,M., Torrents,D.,
            Camps,M., Lloberas,J., Zorzano,A. and Palacin,M.
  CONSRTM   International Cystinuria Consortium
  TITLE     Non-type I cystinuria caused by mutations in SLC7A9, encoding a
            subunit (bo,+AT) of rBAT
  JOURNAL   Nat Genet 23 (1), 52-57 (1999)
   PUBMED   10471498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098909.1, SRR26643290.1786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               JAXUCZ010000001.1  97246439-97246841
            404-511             JAXUCZ010000001.1  97247088-97247195
            512-623             JAXUCZ010000001.1  97247552-97247663
            624-771             JAXUCZ010000001.1  97249960-97250107
            772-1014            JAXUCZ010000001.1  97250898-97251140
            1015-1140           JAXUCZ010000001.1  97251592-97251717
            1141-1240           JAXUCZ010000001.1  97252103-97252202
            1241-1285           JAXUCZ010000001.1  97253443-97253487
            1286-1409           JAXUCZ010000001.1  97253983-97254106
            1410-1513           JAXUCZ010000001.1  97255053-97255156
            1514-1610           JAXUCZ010000001.1  97263488-97263584
            1611-1760           JAXUCZ010000001.1  97264466-97264615
            1761-1935           JAXUCZ010000001.1  97267191-97267365
            1936-2106           JAXUCZ010000001.1  97269374-97269544
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2106
                     /gene="Slc7a9"
                     /note="solute carrier family 7 member 9"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
     exon            1..403
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            404..511
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            512..623
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    528..530
                     /gene="Slc7a9"
                     /note="upstream in-frame stop codon"
     CDS             537..2000
                     /gene="Slc7a9"
                     /note="b(0,+)AT; solute carrier family 7 (amino acid
                     transporter light chain, bo,+ system), member 9;
                     glycoprotein-associated amino acid transporter b0,+AT1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 9; solute carrier family 7
                     (glycoprotein-associated amino acid transporter light
                     chain, bo,+ system), member 9"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_001425366.1"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
                     /translation="MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAIL
                     LITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSV
                     GSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIF
                     YFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE"
     misc_feature    537..605
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    573..1988
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    573..1988
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    588..590
                     /gene="Slc7a9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P82252.1); phosphorylation site"
     misc_feature    630..701
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    723..788
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    867..947
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    978..1043
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1044..1115
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1188..1250
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1290..1358
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1443..1511
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1590..1646
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1647..1709
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1767..1829
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1839..1886
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     exon            624..771
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1014
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1140
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1240
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1285
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1409
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1513
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1610
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1760
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1935
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2106
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagcc cggggagata gtaaagggct ggttccaaag tttattgctg cgattcctca
       61 gttgatgagc ggtttccatt gctgctctga agagatttct cctcacagga agtagccgat
      121 ctggaggaat ccgttttact gcagaaatga tctagataaa caaaaccaaa atgggggaag
      181 ctggacttgt ctgaccccct tattttttgt ctggtggtgt ctatcaaggc tttgttgctt
      241 agaaggaaga aaaaggggga gatgggtgtt taataattac ctctgttgac ctctgtacct
      301 tctggcttcc tccacgccta ggcacaagac atggcccttc ctggggcctg gccctgagtt
      361 gcgggctggg tggtggtcag caaggcaagc atcatcggca aagacaagag tctttctacg
      421 tatcccaggt tggcttgact tgctgaatag cccaggctgg ccctgaattt atcatttttc
      481 tacctcaact acctcagtgc tgggagttca gcccttggaa ctcacagtga gcaaggatgg
      541 aggagacaag cccgaggaga cggagagagg atgagaagtc cgtccacagt acagagccca
      601 agaccacaag tctccagaaa gaggtgggtc ttctcagtgg tatctgtatc attgtgggca
      661 ccatcatcgg ctccgggatc ttcatctccc ccaagtctgt gctggccaac acagaatccg
      721 tggggccctg tctcatcata tgggcagcct gtggagtcct ggctacactg ggcgccctgt
      781 gctttgcaga gcttggcaca atgatcacca agtcaggggg tgagtacccc tatctgatgg
      841 aggccttcgg ccccatccct gcctacctct tctcctggac cagcctgatt gtcatgaagc
      901 cctcatcctt cgccatcatc tgcctcagct tttcagagta tgtgtgtgcg gccttttact
      961 taggctgcag gcctcctgct gtggtagtga aactcctggc tgctgctgcc atcttgctta
     1021 tcactacagt gaatgcgctg agcgtgcggc ttggcagcta tgtgcagaat gtcttcacgg
     1081 cagccaagct ggtgatcgtc gccatcatca tcatcagcgg actggtcctc ctggcgcaag
     1141 gaaatgttaa gaactttcag aattcttttg agggttcaca gacctctgtg ggctccatca
     1201 gcctggcatt ttacaacgga ctctgggcct acgatgggtg gaaccaactt aactacatca
     1261 ctgaagagct tagaaaccct tacagaaacc tgcccatggc cattgtcatt gggatccctc
     1321 tggtgacagt atgctacatc ctcatgaata ttgcttactt cacagtgatg accccaacgg
     1381 agctcttgca gtcccaggct gtggctgtga ccttcggaga ccgtgttctc tatccggcat
     1441 cttgggtagt cccacttttt gtggcatttt caaccattgg tgctgcgaat gggacctgct
     1501 ttacggcggg caggctcatc tatgtggcgg gccgggaagg ccacatgctt aaagtgctat
     1561 cctacatcag tgtcaagcgc ctcactccgg cccctgccct cgtattctat ggcataatag
     1621 ccatcattta catcatcccc ggggacatca actccttagt caattatttc agttttgctg
     1681 catggctctt ttatggcatg acaatcctag gactcgttgt gatgagattc acaaggaaag
     1741 acctagagag gcccatcaag gtgcccatct tcatccctat cattgtgatt ctcgtatctg
     1801 ttttcttgat cctggccccc atcatcagtt cgccagcctg ggaatatctc tactgcgtgt
     1861 tgttcatact gagtggactt atattttact tcctttttgt ccactacaag ttcagatggg
     1921 cccagaaaat ctccaggccg atcaccaagc acctgcagat gctgatggaa gttgtcccac
     1981 cagagaagga cccagagtaa aaggcccatc actcgtagcc caaagctgtg atcaatttat
     2041 ttttgtaagc aattatttgt ggttatttct tcctggtgtt tttcttaatg aaaacatgta
     2101 ttcaga
//
LOCUS       NM_001438406             702 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 5, mRNA.
ACCESSION   NM_001438406 XM_006230897
VERSION     NM_001438406.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 702)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 702)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 702)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 702)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 702)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 702)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 702)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 702)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 702)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 702)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230897.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887621.13046.1,
                                           SRR26360176.984249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000001.1  213563363-213563416
            55-237              JAXUCZ010000001.1  213563668-213563850
            238-428             JAXUCZ010000001.1  213570794-213570984
            429-702             JAXUCZ010000001.1  213571761-213572034
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..702
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..54
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..237
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..599
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 5 is encoded by transcript variant 5; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 5"
                     /protein_id="NP_001425335.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIV
                     QQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWA
                     AQRYGRELRRMSDEFEGSFKGEELTYSVEFLPVRAIAMEGWPLLWSFQSFPHTLPPTP
                     PEVAMFPLRYWTALRRLC"
     misc_feature    63..>431
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    63..>431
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            238..428
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..702
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactggag agaggaggca ggcccgagtc aggggcctcg agaacgggct tgggcccaga
       61 gtatgttcca gatcccagag tttgagccga gtgagcagga agacgctagt actacagata
      121 ggggcctggg ccctagcctc actgaggacc agccaggtcc ctacctggcc ccaggtctcc
      181 tggggagcat cgttcagcag cagccgggac aggcagccaa taacagtcat catggaggcg
      241 ctgggactat ggagacccgg agtcgccaca gttcgtaccc agcggggact gaggaagatg
      301 aagggatgga ggaggagctt agcccttttc gaggacgctc gcgctcggct ccccccaatc
      361 tctgggcagc gcagcgctat ggccgtgagc tccgaagaat gagcgatgaa tttgagggtt
      421 ccttcaaggg agaagagctg acgtacagcg ttgagttcct tccggtgcgt gcaatagcca
      481 tggaggggtg gcccttgctt tggagttttc aaagttttcc acacacccta ccccctacgc
      541 ctccggaagt ggctatgttc cctctccgtt actggacagc cctcaggcgc ctgtgctaag
      601 ttgcgagtcc tggtaaaccg agactgggtg ctgtcctatc atcctagctg gaggccccag
      661 gtcgggagaa acgtgcttta taataaagcc cgcgcatgtg tc
//
LOCUS       NM_001438404            1217 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 2, mRNA.
ACCESSION   NM_001438404 XM_039089714
VERSION     NM_001438404.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_039089714.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.640818.1,
                                           SRR26360194.1888699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000001.1  213562696-213562848
            154-333             JAXUCZ010000001.1  213563052-213563231
            334-516             JAXUCZ010000001.1  213563668-213563850
            517-707             JAXUCZ010000001.1  213570794-213570984
            708-1217            JAXUCZ010000001.1  213571525-213572034
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1217
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..153
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..833
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 2 is encoded by transcript variant 2; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 2"
                     /protein_id="NP_001425333.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MARGVVPKAGGIQAQKGWRTYQPKQASRIQMGTPKQPSLAPAHA
                     LGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQ
                     PGPYLAPGLLGSIVQQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSP
                     FRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRII
                     QSWWDRNLGKGGSTPSQ"
     misc_feature    342..830
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    342..830
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            154..333
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..516
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..707
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1217
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcagg ccccgcgctc cggcctgcag cagagcccct tagagcccca cggctcgccc
       61 tcctgggctc ccctgtccat tcttccgcac ccgggcggcc atcctgccgg aaaggagctc
      121 ccgagatggc gcggggagtt gtccccaagg caggaggaat tcaggcccag aagggctgga
      181 ggacttatca gccgaagcag gcctccagga tccaaatggg aaccccaaag cagccctcgc
      241 tggctcctgc acacgcccta ggcttgagga agtccgatcc cggaatccgg agcctgggga
      301 gcgacgcggg aggaaggcgg tggagaccag cagcccagag tatgttccag atcccagagt
      361 ttgagccgag tgagcaggaa gacgctagta ctacagatag gggcctgggc cctagcctca
      421 ctgaggacca gccaggtccc tacctggccc caggtctcct ggggagcatc gttcagcagc
      481 agccgggaca ggcagccaat aacagtcatc atggaggcgc tgggactatg gagacccgga
      541 gtcgccacag ttcgtaccca gcggggactg aggaagatga agggatggag gaggagctta
      601 gcccttttcg aggacgctcg cgctcggctc cccccaatct ctgggcagcg cagcgctatg
      661 gccgtgagct ccgaagaatg agcgatgaat ttgagggttc cttcaaggga cttcctcgcc
      721 caaagagcgc aggcactgca acacagatgc gacaaagcgc cagttggacg cgcattatcc
      781 agtcctggtg ggatcgaaat ttggggaaag gaggctccac tccctcccag tgatctgctc
      841 cacattcccg gaattctacc cgctcccatc gcccgccata ttgggtgtgg gcggaagtct
      901 ttcgaggcct taggaaaaaa ggatcgctgt gtccctttaa cagggagaag agctgacgta
      961 cagcgttgag ttccttccgg tgcgtgcaat agccatggag gggtggccct tgctttggag
     1021 ttttcaaagt tttccacaca ccctaccccc tacgcctccg gaagtggcta tgttccctct
     1081 ccgttactgg acagccctca ggcgcctgtg ctaagttgcg agtcctggta aaccgagact
     1141 gggtgctgtc ctatcatcct agctggaggc cccaggtcgg gagaaacgtg ctttataata
     1201 aagcccgcgc atgtgtc
//
LOCUS       NR_199377               1293 bp    RNA     linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus vascular endothelial growth factor B (Vegfb),
            transcript variant 4, non-coding RNA.
ACCESSION   NR_199377
VERSION     NR_199377.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Tu,S., Wang,X.Y., Zeng,L.X., Shen,Z.J. and Zhang,Z.H.
  TITLE     LncRNA TINCR improves cardiac hypertrophy by regulating the
            miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway
  JOURNAL   Lab Invest 102 (3), 253-262 (2022)
   PUBMED   34732848
  REMARK    GeneRIF: LncRNA TINCR improves cardiac hypertrophy by regulating
            the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Shang,R., Lal,N., Lee,C.S., Zhai,Y., Puri,K., Seira,O.,
            Boushel,R.C., Sultan,I., Rasanen,M., Alitalo,K., Hussein,B. and
            Rodrigues,B.
  TITLE     Cardiac-specific VEGFB overexpression reduces lipoprotein lipase
            activity and improves insulin action in rat heart
  JOURNAL   Am J Physiol Endocrinol Metab 321 (6), E753-E765 (2021)
   PUBMED   34747201
  REMARK    GeneRIF: Cardiac-specific VEGFB overexpression reduces lipoprotein
            lipase activity and improves insulin action in rat heart.
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Lal,N., Chiu,A.P., Wang,F., Zhang,D., Jia,J., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     Loss of VEGFB and its signaling in the diabetic heart is associated
            with increased cell death signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (6), H1163-H1175 (2017)
   PUBMED   28314760
  REMARK    GeneRIF: Loss of VEGFB and its downstream signaling is an early
            event following hyperglycemia, is sustained with disease
            progression, and could explain diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Monastero,R., Garcia-Serrano,S., Lago-Sampedro,A.,
            Rodriguez-Pacheco,F., Colomo,N., Morcillo,S., Martin-Nunez,G.M.,
            Gomez-Zumaquero,J.M., Garcia-Fuentes,E., Soriguer,F.,
            Rojo-Martinez,G. and Garcia-Escobar,E.
  TITLE     Methylation patterns of Vegfb promoter are associated with gene and
            protein expression levels: the effects of dietary fatty acids
  JOURNAL   Eur J Nutr 56 (2), 715-726 (2017)
   PUBMED   26707994
  REMARK    GeneRIF: Data suggest that dietary fatty acids create
            epigenetic/nutrigenomic changes in methylation levels of CpG island
            at Vegfb promoter and changes in Vegfb expression in white
            adipocytes in vivo and in vitro, with particular up-regulation of
            DNA methylation by linoleic acid; Vegfb promoter methylation levels
            are closely related to Vegfb gene expression in visceral and
            subcutaneous adipose tissue.
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Nag,S., Eskandarian,M.R., Davis,J. and Eubanks,J.H.
  TITLE     Differential expression of vascular endothelial growth factor-A
            (VEGF-A) and VEGF-B after brain injury
  JOURNAL   J Neuropathol Exp Neurol 61 (9), 778-788 (2002)
   PUBMED   12230324
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Ikuta,T., Ariga,H. and Matsumoto,K.
  TITLE     Extracellular matrix tenascin-X in combination with vascular
            endothelial growth factor B enhances endothelial cell proliferation
  JOURNAL   Genes Cells 5 (11), 913-927 (2000)
   PUBMED   11122379
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Bellomo,D., Headrick,J.P., Silins,G.U., Paterson,C.A., Thomas,P.S.,
            Gartside,M., Mould,A., Cahill,M.M., Tonks,I.D., Grimmond,S.M.,
            Townson,S., Wells,C., Little,M., Cummings,M.C., Hayward,N.K. and
            Kay,G.F.
  TITLE     Mice lacking the vascular endothelial growth factor-B gene (Vegfb)
            have smaller hearts, dysfunctional coronary vasculature, and
            impaired recovery from cardiac ischemia
  JOURNAL   Circ Res 86 (2), E29-E35 (2000)
   PUBMED   10666423
REFERENCE   9  (bases 1 to 1293)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   10 (bases 1 to 1293)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.926318.1,
                                           SRR22399484.1156393.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000001.1  213606838-213607199 c
            363-405             JAXUCZ010000001.1  213606264-213606306 c
            406-602             JAXUCZ010000001.1  213605781-213605977 c
            603-638             JAXUCZ010000001.1  213605110-213605145 c
            639-874             JAXUCZ010000001.1  213604668-213604903 c
            875-1293            JAXUCZ010000001.1  213601570-213601988 c
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Rattus norvegicus"
                     /mol_type="transcribed RNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1293
                     /gene="Vegfb"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     misc_RNA        1..1293
                     /gene="Vegfb"
                     /product="vascular endothelial growth factor B, transcript
                     variant 4"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     exon            1..362
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    303..719
                     /gene="Vegfb"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_053549.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            363..405
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            406..602
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            603..638
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            639..874
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1293
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgtccg ccagccccgg ccaggccccc tgccaccccc gccgtccccg ctgcccgccg
       61 tcccggccac caccaccaac acaggccgcc tgcctgtctc gttccttctg ccgccgctga
      121 ggcgctacgt tgcgctgcct gcgcccaggg ctcgggaggg ggccgcggag gagccgcccc
      181 ccgcgcccgg cccggggtcc ccacacccgg gcccgcgcca tgggactctg gctgccgccg
      241 ccccccgcgc cgccgggcta gggcaatgcg gtcgcccccg gcgctcggcc cccgcgggca
      301 ccatgagccc cctgctccgt cgcttgctgc ttgttgcgct gctgcagctg gcctgtaccc
      361 aggcccctgt gtcccagttt gatggcccca gccaccagaa gaaagtggtg tcatggatag
      421 atgtttatgc acgtgccaca tgccagccca gggaggtggt ggtacctctg agcatggaac
      481 tcatgggtaa tgtggtcaaa caactcgtgc ccagctgtgt gactgtgcag cgctgtggtg
      541 gctgctgtcc tgacgatggc ctggagtgtg tgcccattgg gcaacaccaa gtccgaatgc
      601 agaccaaaaa gaaaggagag tgctgtgaag ccagacaggg ttgccatacc ccaccaccgt
      661 ccccagcccc gctctgttct gagctgggac tctgccccgg gagcatcctc cccagctgac
      721 atcatccatc ccactccagc cccaggaccc tctgcccacg ctgcacccag cgccgtcagc
      781 gccctgatcc ccggacctgc cgttgccgct gcagacgccg ccgcttcctc cattgccaag
      841 ggcggggctt agagctcaac ccagatacct gcaggtgccg gaagctgcga aggtgacaag
      901 ctgcttttcg gactccacag gcctgtgtgc ctcacaggcc ttcttcatag ggagaagagt
      961 ggagcatagg agaaccacct cagtctggga ggacattgcc ccaggacttg gagcttttag
     1021 agagctctca ccatctttta tctcccagag ctgccttcta acaattgtca agagaacctc
     1081 atgcctcacc ttaggggcca gggtactatc tcagttagcc actctggtca agtgaacatc
     1141 ttgctggctg tctcccctca ctatgaagac cccaaacttc taccaatact aggacttggg
     1201 ttgttatgat aactgtgaca cacacacaca cacacacaca cacacacaca cacacacaca
     1261 cacacactct gataaaagaa atggaagaca cta
//
LOCUS       NM_001438162             761 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus adipogenesis associated, Mth938 domain containing
            (Aamdc), transcript variant 1, mRNA.
ACCESSION   NM_001438162 XM_017589374
VERSION     NM_001438162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   Ma,X., Ding,W., Wang,J., Wu,G., Zhang,H., Yin,J., Zhou,L. and Li,D.
  TITLE     LOC66273 isoform 2, a novel protein highly expressed in white
            adipose tissue, induces adipogenesis in 3T3-L1 cells
  JOURNAL   J Nutr 142 (3), 448-455 (2012)
   PUBMED   22279136
REFERENCE   2  (bases 1 to 761)
  AUTHORS   Wang,H., Ma,X., Zhang,H., Zang,J., Hu,S. and Li,D.
  TITLE     Involvement of LOC66273 isoform 2, a novel Mth938 containing
            protein, in MAPK pathway
  JOURNAL   Front Biosci (Elite Ed) 3 (4), 1241-1248 (2011)
   PUBMED   21622130
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_017589374.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.4359.1,
                                           SRR26360181.2887814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  161303116-161303192 c
            78-126              JAXUCZ010000001.1  161301714-161301762 c
            127-276             JAXUCZ010000001.1  161287359-161287508 c
            277-372             JAXUCZ010000001.1  161281014-161281109 c
            373-761             JAXUCZ010000001.1  161273216-161273604 c
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..761
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="adipogenesis associated, Mth938 domain containing"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
     exon            1..77
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            78..126
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    115..117
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="upstream in-frame stop codon"
     exon            127..276
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..513
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /codon_start=1
                     /product="mth938 domain-containing protein"
                     /protein_id="NP_001425091.1"
                     /db_xref="GeneID:361606"
                     /db_xref="RGD:1561459"
                     /translation="MLMASPKIASLSWGQMKVQGSTLTYKDCKVWPGGSRAWDWRETG
                     TEHSPGVQPADVKEVAEKGVQTLVIGRGMSEALKVPPSTVEYLEKQGIDVRVLQTEQA
                     VKEYNALAARGIRVGGVFHSTC"
     misc_feature    157..504
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="Mth938 domain. Mth938 is a hypothetical protein
                     encoded by the Methanobacterium thermoautotrophicum (Mth)
                     genome. This protein crystallizes as a dimer, although it
                     is monomeric in solution, with one disulfide bond in each
                     monomer. The function of the...; Region: Mth938; cd05126"
                     /db_xref="CDD:240162"
     misc_feature    157..504
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /note="Mth938 domain. Mth938 is a hypothetical protein
                     encoded by the Methanobacterium thermoautotrophicum (Mth)
                     genome. This protein crystallizes as a dimer, although it
                     is monomeric in solution, with one disulfide bond in each
                     monomer. The function of the...; Region: Mth938; cd05126"
                     /db_xref="CDD:240162"
     exon            277..372
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
     exon            373..761
                     /gene="Aamdc"
                     /gene_synonym="RGD1561459"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatctctc agctagctgc agggagaggt agagcgcgga gccgactgga ggagcaaccg
       61 aagaacagaa gcgctgcgtg gcaaaggcag gaagaacacc gagttcaggc cagctagggc
      121 tataagattt cagttcacat gcttatggct tcccctaaaa ttgcttccct ctcttgggga
      181 caaatgaaag ttcaaggctc taccttaacc tataaggatt gcaaagtatg gccaggaggc
      241 agtcgggctt gggattggag agaaacagga actgagcatt ctcctggagt gcagccagca
      301 gacgtaaagg aagttgctga gaagggtgta cagactcttg tgattggcag aggaatgagc
      361 gaggccttga aggtgcctcc atcgactgtg gagtacctcg agaaacaagg cattgatgtg
      421 cgagtcctcc agacagagca ggcagtgaag gagtacaatg ccttggctgc ccgggggata
      481 agggtaggag gtgtcttcca ttccacctgc tgatggagcc tacagaggag aataaacctc
      541 tgggcagcaa tgccttacca tctccacatc agcctcctct gtgtactttg gacacatgtt
      601 catgttcttg gaacagattg atgggaggct aaggcaaagt tcttgccctc caggttgctt
      661 aaatcagaag agagatttgc tgattttagt attgtactat gtgttcggtt caaagtatga
      721 gaaagttcat acaaaaataa aggttgaagc ttagaagcca a
//
LOCUS       NM_001438199            2579 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), transcript
            variant 2, mRNA.
ACCESSION   NM_001438199 XM_006229912
VERSION     NM_001438199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2579)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2579)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2579)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2579)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2579)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2579)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229912.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.3157.1,
                                           SRR26360176.427757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000001.1  168148669-168148844 c
            177-652             JAXUCZ010000001.1  168141182-168141657 c
            653-748             JAXUCZ010000001.1  168139744-168139839 c
            749-979             JAXUCZ010000001.1  168138006-168138236 c
            980-1002            JAXUCZ010000001.1  168135410-168135432 c
            1003-1103           JAXUCZ010000001.1  168134230-168134330 c
            1104-1130           JAXUCZ010000001.1  168133975-168134001 c
            1131-2579           JAXUCZ010000001.1  168132277-168133725 c
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2579
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..176
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            177..652
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    194..196
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="upstream in-frame stop codon"
     CDS             233..1768
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2;
                     tripartite motif-containing protein 5"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5 isoform 1"
                     /protein_id="NP_001425128.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MASEFVMNLKEEVTCPICLDLMVEPVSGDCGHSFCQACITLNYE
                     SSKCNQDEFICPVCRVSYLFKNLRPNRHVANIVQRLKEFKSSPEEEPKVLSCARHGEK
                     LQLFCKKDMMPICWLCERSQEHRGHQTVLIEEVVQEYKEKLQAALQKLMADKKEFENW
                     KDDLQKERTYWQNQIQKDVENVQSEFKGMRDIMDSEEKKELQKLMQEKEDIMSSLEES
                     ENEYSQQSKLLGDLILDVEHQLQCSATEMLQGVENTIKRSHTFSMRKPKTIPKEQRRV
                     FRAPDLQGMLQVLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARP
                     TENCHAGVLGYPAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPL
                     FRLNLSNDSHSRLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLM
                     VRPCRVGIFLDCAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICW
                     PDS"
     misc_feature    254..466
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    254..466
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; Region: RING-HC_TRIM5-like_C-IV;
                     cd16591"
                     /db_xref="CDD:438253"
     misc_feature    order(278..283,287..292,398..403,407..409)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    order(278..283,287..292,398..403,407..409)
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438253"
     misc_feature    515..631
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    515..631
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; Region: Bbox2_TRIM5-like;
                     cd19761"
                     /db_xref="CDD:380819"
     misc_feature    626..>931
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    626..>931
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="Periplasmic chaperone for outer membrane proteins,
                     Skp family [Cell wall/membrane/envelope biogenesis,
                     Posttranslational modification, protein turnover,
                     chaperones]; Region: HlpA; COG2825"
                     /db_xref="CDD:442073"
     misc_feature    1100..1753
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     misc_feature    1100..1753
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     Region: SPRY_PRY_TRIM5; cd15822"
                     /db_xref="CDD:293994"
     exon            653..748
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            749..979
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1002
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1103
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1130
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..2579
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccagcg ctcaaacttt ggttcctctt agagtggggt cttaagtatc ttgaaattct
       61 ggattagcga gttaattttc tgtgatttac gaattctcgg tgtctgaaag ccggtggaac
      121 aattttaggg agcaaagttt tgaggacttt ggaaggaaaa cattgctttt gcttgggcac
      181 ctgagcagac gtgtgaggag tcagtagagt cagacacagg atcacagcaa ctatggcttc
      241 agaattcgtg atgaatttaa aagaggaggt gacctgtcct atctgcctgg acctgatggt
      301 agaacctgtg agtggagatt gtggtcacag cttctgccaa gcctgcatca cgctgaacta
      361 tgaatccagc aaatgcaatc aggatgagtt catttgccct gtgtgccgag ttagttacct
      421 gtttaagaac ctgaggccca atcgacatgt ggccaacata gtgcagaggc tcaaagagtt
      481 caagtccagc ccagaagagg agccgaaggt gctttcttgt gcaaggcatg gagagaaact
      541 ccagctcttc tgtaagaagg acatgatgcc catctgctgg ctttgtgagc gatctcagga
      601 gcaccgtgga caccaaacag ttctcattga agaggtggtc caggagtata aggagaagct
      661 gcaggcagct ctgcaaaagc tgatggcaga caagaaagaa tttgagaact ggaaagatga
      721 ccttcaaaag gagagaactt actggcagaa tcaaatacag aaagatgtgg aaaatgtcca
      781 gtcagagttt aaaggaatga gagatatcat ggactctgag gagaagaagg aattgcagaa
      841 gctgatgcaa gagaaggaag acattatgag cagcctggaa gagtctgaaa atgagtattc
      901 tcagcagagt aagttgctag gagacctcat cttagatgtg gaacatcagt tacaatgctc
      961 agccacggaa atgctgcagg gtgtagagaa caccataaaa cggagtcata ctttttcgat
     1021 gaggaagccc aaaaccatcc ccaaggaaca aagaagagtg ttccgagccc ctgatctgca
     1081 aggcatgctg caagtgttac aagaggtcac agaggcccaa cgctactggg ttcaagtgac
     1141 gctggttgaa agcaacaatc caaacatttt cattaccgcc gacaaaagac agatacgata
     1201 tgaagaccac caagcaagac attttgcccg tccgactgaa aactgtcatg caggtgtcct
     1261 gggataccca gctatccaat caggaaaaca ctactgggaa gtagatgtgt ctggaaaagg
     1321 ttcttgggtt ctgggattaa gtgatggaag ctacctcttt aatccaatat ttcgttcaaa
     1381 tgcagaaaga cccccaaacc cccccttatt tcgtttgaat cttagtaatg attcacattc
     1441 tcgtttgagt cttagtaatg attcacatta tcaacctaaa tatggcttct gggttatagg
     1501 gctgtgggga aattctgtgt ataatgcttt tgaggagtgt acgttcacag gcaagcccag
     1561 tgtgttgacc ctctctctga tggtccgacc ctgtcgtgtc ggtattttcc tcgactgtgc
     1621 agctggcacc ctctcgtttt acaatatttc caaccatggc actcttatct acagattctg
     1681 tgcaggttcc tttcctgata gggtttttcc atattttaac cccatgggaa gttcagagcc
     1741 attgacaata tgctggccag actcttaatc ttcactgtct ctgtgcatgg tctctggtcc
     1801 tgatgtgtat gtcatgtgcc tgagctcatc agcactattt tatcgttttg ttcatgtctc
     1861 taatctttca ttggaaaata tattcatttc tctaggccat attctcagtt tcttggggta
     1921 ttttttgtct ttgttttgtt ttgtttttag gtgagactaa caaatcactt cccatatagt
     1981 caaggacaaa tgtctagtgc tcactgcgta agataacacc gatgcaaaat tcctcttatt
     2041 cttcatgcca gagatggaag gcaaggcctt gtgcacggtg aggatgtgct ccaccgctga
     2101 gctgtttgct tcagctgtca tgtccctata acctcattcg gcccatcaat gaaagattaa
     2161 agaaggttct tcgacaactt gtctattcat gctgaaaatt atatatagga gtctctgctt
     2221 aagaaatgca ccctgagctg taggccaaag aatgaaggag aagcatcaca agaagcctta
     2281 tcactgtgac taaattaagt gatcattaag actgtgcatc agtcttgcct gggagctcat
     2341 acctgccatc ctgcatctgg gaagttgtgg caggaagatt gctgtgtatt tgaagccacc
     2401 cttgtataga gttaagagcc tgcttaaaaa aaataatcaa gaatatgtat aaaaaccact
     2461 actctatttt gttctaagaa atagaataac tagatttcag aattgcaggg tttgggtcgt
     2521 tttcacaatt tgtaaataaa tgtttactaa aaataaatgt taacttcata gctgtccaa
//
LOCUS       NM_001438131            1350 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus proline rich and Gla domain 2 (Prrg2), transcript
            variant 1, mRNA.
ACCESSION   NM_001438131 XM_008759397
VERSION     NM_001438131.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759397.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1517360.1,
                                           SRR26360172.259024.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  104679769-104679813 c
            46-110              JAXUCZ010000001.1  104678978-104679042 c
            111-264             JAXUCZ010000001.1  104678247-104678400 c
            265-446             JAXUCZ010000001.1  104677743-104677924 c
            447-486             JAXUCZ010000001.1  104677511-104677550 c
            487-628             JAXUCZ010000001.1  104673619-104673760 c
            629-757             JAXUCZ010000001.1  104671671-104671799 c
            758-1350            JAXUCZ010000001.1  104670748-104671340 c
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1350
                     /gene="Prrg2"
                     /note="proline rich and Gla domain 2"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
     exon            1..45
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..110
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Prrg2"
                     /note="upstream in-frame stop codon"
     exon            111..264
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..776
                     /gene="Prrg2"
                     /note="transmembrane gamma-carboxyglutamic acid protein 2;
                     proline-rich Gla (G-carboxyglutamic acid) polypeptide 2;
                     proline rich Gla (G-carboxyglutamic acid) 2"
                     /codon_start=1
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     2 precursor"
                     /protein_id="NP_001425060.1"
                     /db_xref="GeneID:361570"
                     /db_xref="RGD:1305444"
                     /translation="MRSHPSLLLVYMGLATCLDTLPHREQSQVLDIFLDAPEAQSFLV
                     GRRRFPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYAYNGKG
                     GRGRVDVAGLAVGLTSGILLIVLAGLGAFWYLHYRRRRLRVQESCLQETGLIIPLSPP
                     TPLSPPPPPGLPTYEQALAASGVHDAPPPPYSSLRRPH"
     sig_peptide     180..230
                     /gene="Prrg2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    276..467
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     misc_feature    276..467
                     /gene="Prrg2"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; Region: GLA; smart00069"
                     /db_xref="CDD:214503"
     exon            265..446
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..486
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..628
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..757
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1350
                     /gene="Prrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaataact ctgcccctag ttgtggaggc gcttctcctc tcttgctggc tactgctaac
       61 ccagagggtc ttcattcaag aagagaagca ggcctcccag ccctggacag agtctgggca
      121 gggagtcctg gggcctcata actctgctga ggcatttgtc atctgggagt tcacacaata
      181 tgaggagcca tccttccctg ctcttagtct acatgggatt ggccacctgc ctggacacct
      241 tacctcatag agagcaaagc caagttcttg acatcttcct ggatgcccca gaggcccaga
      301 gtttcttagt tggccgcagg cgttttcctc gtgctaacca ctgggacctg gagttgctga
      361 cccctgggaa cctggaacgg gagtgtctgg aagagaggtg ctcctgggag gaggcccggg
      421 agtactttga ggacaacaca ctgacggagc gtttctggga aagctatgca tacaacggca
      481 agggagggcg tggacgggtg gatgttgcag gcctggcagt gggactgacc tctgggatcc
      541 tgctcatcgt gttggctggc ttgggagcct tttggtatct gcattatcga cggcgccgcc
      601 tcagagtcca ggagtcctgt ctgcaagaga ccgggctcat catcccctta agtcctccga
      661 cgcctctgtc tccaccgcct cccccaggcc ttcccaccta tgagcaggct ttagcagcct
      721 ccggggtgca cgacgcccct ccaccccctt actccagcct cagaaggccc cactgaagac
      781 ctgctccgag cgcgggctcc ctcaactgtg cccctgattc atagcggatt ccggaagtcg
      841 ccggcttctt cgacgactag gcttcagtgt gtccgtgggg gagtcggggt cgtcggaccc
      901 ggggtctaca tgacacacgt gtttccgccg ggcacgcata cacgcatgtc cctgaccatc
      961 ctgttgccga gtcggtgccc ctggcccgcg cgtgaacccc cacttctgct gagccttgcc
     1021 tcagaatgga cagacttttt aggaaactcg gaccagacgt gactcggctg tcaccccact
     1081 ggtgccgcgg agcgcgtaca ctcagggaac caggccctta cacacgcctt acttggtgta
     1141 tttccccact cgtgcacatg ggcggttcgt aatccagcat aaagatgggg ggcacatttg
     1201 caatgtgctg taagtggggt gtcaacgctt gtgttgcacc cgggtaaatg gagttgatct
     1261 gagctgccct ttacttaaaa accctttggg aaaagggtgg aagaaattaa aattgaaaca
     1321 ataagaaaaa taaaaatgca aaagaactga
//
LOCUS       NM_001438230            4383 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus IKAROS family zinc finger 5 (Ikzf5), mRNA.
ACCESSION   NM_001438230 XM_006230401
VERSION     NM_001438230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4383)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   2  (bases 1 to 4383)
  AUTHORS   Perdomo,J., Holmes,M., Chong,B. and Crossley,M.
  TITLE     Eos and pegasus, two members of the Ikaros family of proteins with
            distinct DNA binding activities
  JOURNAL   J Biol Chem 275 (49), 38347-38354 (2000)
   PUBMED   10978333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006230401.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.3742.1,
                                           SRR26643292.4384.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000001.1  195618887-195618985 c
            100-279             JAXUCZ010000001.1  195606491-195606670 c
            280-462             JAXUCZ010000001.1  195604450-195604632 c
            463-4383            JAXUCZ010000001.1  195599190-195603110 c
FEATURES             Location/Qualifiers
     source          1..4383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4383
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="IKAROS family zinc finger 5"
                     /db_xref="GeneID:309031"
                     /db_xref="RGD:1310965"
     exon            1..99
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="upstream in-frame stop codon"
     exon            100..279
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1406
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="zinc finger protein, subfamily 1A, 5"
                     /codon_start=1
                     /product="zinc finger protein Pegasus"
                     /protein_id="NP_001425159.1"
                     /db_xref="GeneID:309031"
                     /db_xref="RGD:1310965"
                     /translation="MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAETLQG
                     AGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIR
                     IHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRK
                     HKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHE
                     IPNIQTDSYETMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPD
                     VDPCPDEKPFMIQQPSAQAVVSAVSASIPQSSSPTSPDPRPSHSQRNYSPVAGPSSEP
                     SAHTSTPSIGNSQPSTPAPTLPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGYENPF
                     QCNICGCKCKNKYDFACHFARGQHNQH"
     misc_feature    396..458
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    396..458
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(411..413,417..419,423..425,429..434,441..446,
                     453..455,495..497,501..503,513..518,525..530,537..539,
                     579..581,585..587,591..593,597..602,609..614)
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(411..413,417..419,423..425,429..434,441..446,
                     453..455,495..497,501..503,513..518,525..530,537..539,
                     579..581,585..587,591..593,597..602,609..614)
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    432..509
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    432..509
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    480..542
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    480..542
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    516..590
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    516..590
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    564..620
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    564..620
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    897..>1229
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="envelope glycoprotein C; Provisional; Region:
                     PHA03269"
                     /db_xref="CDD:165527"
     misc_feature    897..>1229
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /note="envelope glycoprotein C; Provisional; Region:
                     PHA03269"
                     /db_xref="CDD:165527"
     exon            280..462
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     exon            463..4383
                     /gene="Ikzf5"
                     /gene_synonym="Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaacaaata tggcggctac agctgcgacg ctgacgaacg ctgaggcggt ggcggcgacg
       61 aacaaggctg tggggattcc tcggtgcagt tgtcaggaga tataacagac tttcaactta
      121 aagagagaaa gaaagaaagc accaagatgg gtgaaaagaa gccagagcct ttggacttcg
      181 tcaaagattt ccaggaatac ctgacacagc agacgcatca tgtgaacatg atttcgggat
      241 cagttagtgg ggacaaagaa gcagagactc ttcagggagc tggaacagat ggcgatcaaa
      301 acggacttga tcacccatct gttgaagttt ccctggatga aaactcagga atgttagtag
      361 acgggtttga aaggaccttc gatgggaagc tcaagtgccg gtactgcaac tatgccagta
      421 aagggacggc ccggctcatc gagcacatca ggatccacac aggcgagaag cctcatcgat
      481 gtcacttatg tccgtttgca tctgcttatg agcgccatct ggaagcccac atgcgctctc
      541 acactgggga aaaaccatac aaatgtgaat tgtgttcctt ccgctgcagt gaccgaagca
      601 acctgtccca ccatcgaagg cgcaaacata aaatggtacc aattaaaggt accaggtctt
      661 ccttaagcag caagaaaatg tggggagttt tacaaaagaa aacaagcaat cttgggtata
      721 gcagaagagc actaatcaac ttaagtccgc cttccatggt ggtccagaaa ccagactacc
      781 ttaacgattt tacccatgaa attccaaata ttcagaccga ctcctacgaa accatggcaa
      841 aaaccacacc aactggtggc ctgccaaggg acccccaaga actcatggtt gacaaccctt
      901 tgaatcagct ctctacttta gcaggacagt tgtccagctt gccaccagaa aaccaaaacc
      961 ctgcctcccc tgatgtagat ccctgccctg atgaaaagcc tttcatgatc cagcagccct
     1021 ctgcccaagc agtagtctct gctgtgtcag caagtattcc tcagagctcc tcccccacaa
     1081 gtccagaccc tcggccgtcg cacagccaga ggaactacag tccagtggca gggcccagca
     1141 gtgaaccaag tgcccacacc agtaccccca gcataggaaa cagccagcca agcactccag
     1201 ctccaaccct gccggtccag gatcctcagc ttctgcacca ctgccagcac tgtgatatgt
     1261 actttgcaga caatatcctt tacactattc acatgggatg ccatgggtat gagaacccct
     1321 ttcagtgtaa tatatgtgga tgcaaatgta aaaacaagta tgattttgcc tgtcattttg
     1381 caagagggca gcataaccag cactgaacac agtcagcatt gatctcactt ggtttggcct
     1441 ttggggagtt tgtagtttgg tctttagttt gatcatccct aataaggtat atgctaattt
     1501 aaaatttata cattttattc ataaaataga agtttgatag tgagaaaagg ttttgttaac
     1561 ttttcataaa agtctgttca gggttattta tgcattagat agttaggtgc attgttgtct
     1621 tttcctttag ccttctgaga cttcctacac ttgtcctgag gactccaggg taatcctgac
     1681 tcttgatgct ttagtgtgta cattacagcg aaacattctt cctgccatag ttcaaaatgg
     1741 cacaataaac ttctcatgca atcttttgta acatttcagt gtttatagac aaactgcctt
     1801 taagtttgct tttaattcac ataacttaac ttgagttagt tttattacaa ccaaaaccag
     1861 tagttatttc agtgtaataa atctcttcaa gggcaagtat aaaacaattc ttttcaaatt
     1921 taaattataa aaatgcaagt cttggaactt gaaatttggg ctaagttgaa aattgtgttc
     1981 agtatttgag atatctgttc attttctgtg taaacatgtt tgtgtttcat ttatatatat
     2041 ttatgtattt tgagtattct tttaaagcca caggtaaata tattagagtg ctagatgcct
     2101 ttttcgatct gaatccttca ttcaaattct gcactcactg gtgtcaggta agattgacag
     2161 ccacactgat tactttattc ttcctagtct tcgatgacca aagaggaagg agaacgcatc
     2221 catcttagta agatgcttca aaacagtctc caaggtttcc ttgtctgcct tctgtacatt
     2281 tatcgccctt aatttccaag aaggggcgat gtagagaccc agaaaaatgt actagtgaag
     2341 aaacagtaca gtaatgagag catgcccaga gcagagcagg ccatagaagt ccccctgtga
     2401 gtcttcatgg acagagacgg tgggataatc accaccgtgg gaaaggataa agagtgaaag
     2461 ttattatgaa gcacattgaa atgtgacatt taatttacct ataattagag tggttcattt
     2521 tatataggaa gccactattt ttgtatcgtg taataagtag cttactttga agagagcctg
     2581 gcaaaacaat aaaacattgt cagttactat tggtttctgt gtactttgca aatttttcat
     2641 ttttatttgg ttaatatctt gaaaactttc ccaattggct tcttaaagaa ataccctgtc
     2701 aatcattatt aaccaaaaat cacctcttac agtaattaag agggaaatac tgagagtgtc
     2761 tacccattaa gtcccaagtg ccctgttaat ggatctgtgc cctccttccc tccctgtgct
     2821 agaaagccat tcagagggtg cctgtgctta catagccagt cttggctcat cctgactgca
     2881 ctgttaaagc gcagccccaa agacactttc tcttctgatc ctaactttct agtgattttg
     2941 gtctgatgct taaatcattc acaagattcg ttttagcaca acactttcca aatacataac
     3001 ttgactgttg tgcttatcag ctgccagaaa gaaacaggtg ggtgtttgga aactttgctg
     3061 ttttcaaact ttgattcaac taaaagcaat actcccaaat agacagtgaa agcttcctga
     3121 gacaggaaga agcccagagc actgctgcac acctctagtc ccagctgctt gggaaacaga
     3181 ggcaggaaga gtgcaagacg tgtctcaaag gccacagacc ctgaaagggc tctccttcca
     3241 gccagttgta tcacctacat tctgggccaa acagtgacac gtgcattttg tttttcctaa
     3301 caactaagga tgaatgtttt gaaggtaaat ttcattttaa ctatggaaaa gacttttcat
     3361 agttacagac tagaagtaaa gaaatcctaa ttttccaata acataagagc acagttggtc
     3421 ttccaaaggt gtcgatgcat gaagctacaa gtacttcgga atgcactaaa attttgaagc
     3481 aaatctacct taggaacttt tgaaattgta cttttaaaga tttaggattt tgcttaaata
     3541 ttctgagtta aattctgtac taggaaagat gttggattct ttccttaaat actaaatatg
     3601 ttcctcattt tatttttaac caaatgtttt atagaaatga gttgagaaaa gtttaacatg
     3661 cactatttat agtactttgc cattaacagg caatgttctg aaactaaatt tatttttgtt
     3721 cagtgaacat gagtttagat ttttaaagtt ggtaatttat ctccactact atttttttaa
     3781 actgtgaaga gattaacaga ataattttat ttcagatttt actaatgtcg tgtgtagcta
     3841 caattcttga cattcaagtg aagacgagac ttgtgttttg agattttttt cccatcgggt
     3901 agtttcagtg gtttcatttt agaaatgggt ttgctgttca tctgcagatg tttgacaaag
     3961 ggaatgttac tgaaaaagaa aaaaaaaaaa cttaccaaat gaagaattgt tagaaaaaaa
     4021 aattaagttc cctgctaaag acatttttgt tagtcttagg gggtaggtat ttgctttcta
     4081 gaacttgttt ctgttgatac ctggatgtag ggaacatgtt ttacacctat gcgaggtgta
     4141 agtcttgcat tacagttgta agatacatta tattgtttag ggatcaagaa agcaatccag
     4201 tgctgaagta actatagtat gtagttccaa ttgtgaataa tgctttgctt ttgtaatgta
     4261 tgaataaaaa taacactttc taatgacttc tgttttttgt tttttaaaac tagaatcaaa
     4321 ttgattttta tgtaacttac agtaaagata tcaataaaag attttatggt tggctagttc
     4381 aaa
//
LOCUS       NM_001438188            6565 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 2 (Man2a2),
            transcript variant 3, mRNA.
ACCESSION   NM_001438188 XM_008759530
VERSION     NM_001438188.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6565)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759530.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.2033.1,
                                           SRR26643298.3591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               JAXUCZ010000001.1  143736479-143736867 c
            390-587             JAXUCZ010000001.1  143736112-143736309 c
            588-738             JAXUCZ010000001.1  143734935-143735085 c
            739-996             JAXUCZ010000001.1  143733704-143733961 c
            997-1141            JAXUCZ010000001.1  143733490-143733634 c
            1142-1313           JAXUCZ010000001.1  143733200-143733371 c
            1314-1441           JAXUCZ010000001.1  143732663-143732790 c
            1442-1615           JAXUCZ010000001.1  143732254-143732427 c
            1616-1802           JAXUCZ010000001.1  143731769-143731955 c
            1803-1980           JAXUCZ010000001.1  143728703-143728880 c
            1981-2183           JAXUCZ010000001.1  143728263-143728465 c
            2184-2366           JAXUCZ010000001.1  143727948-143728130 c
            2367-2481           JAXUCZ010000001.1  143727685-143727799 c
            2482-2549           JAXUCZ010000001.1  143727397-143727464 c
            2550-2715           JAXUCZ010000001.1  143727107-143727272 c
            2716-2952           JAXUCZ010000001.1  143725781-143726017 c
            2953-3075           JAXUCZ010000001.1  143724508-143724630 c
            3076-3190           JAXUCZ010000001.1  143724133-143724247 c
            3191-3324           JAXUCZ010000001.1  143723765-143723898 c
            3325-3466           JAXUCZ010000001.1  143722979-143723120 c
            3467-3603           JAXUCZ010000001.1  143721013-143721149 c
            3604-3798           JAXUCZ010000001.1  143718013-143718207 c
            3799-3906           JAXUCZ010000001.1  143717730-143717837 c
            3907-6565           JAXUCZ010000001.1  143713966-143716624 c
FEATURES             Location/Qualifiers
     source          1..6565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6565
                     /gene="Man2a2"
                     /note="mannosidase, alpha, class 2A, member 2"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
     exon            1..389
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..587
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    565..567
                     /gene="Man2a2"
                     /note="upstream in-frame stop codon"
     exon            588..738
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..4059
                     /gene="Man2a2"
                     /EC_number="3.2.1.114"
                     /note="isoform 2 is encoded by transcript variant 3;
                     alpha-mannosidase 2x; mannosidase 2, alpha 2"
                     /codon_start=1
                     /product="alpha-mannosidase 2x isoform 2"
                     /protein_id="NP_001425117.1"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPEDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLETHLRGAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNG
                     VKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVRRVDEEQEQQVDMK
                     LFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEVAAYYEHFHQVIR
                     LYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNHFRLLLERRTLMSPEVQQERSTSYPSLLSHMTSMYLNTPPLVLPVA
                     KRESTSPTLHSFHPLASPLPCDFHLLNLRMLPAEDTLPAADAALILHRKGFDCGLEAK
                     NLGFNCTTSQGKLALGSLFHGLDVLFLQPTSLTLLYPLASPSNSTDISLEPMEISTFR
                     LRLG"
     misc_feature    1024..4053
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     misc_feature    1024..4053
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     exon            739..996
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1141
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1313
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1441
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1615
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1802
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1980
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2183
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2366
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2481
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2549
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2715
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2952
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3075
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3190
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3324
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3466
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3603
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3798
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3906
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..6565
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagtggacc ccagcgccga cccagcggga ggagaccgag ctgggtgcca gggggcgctg
       61 cggaacccgg cggggggcga ggcagcggcg gggcccggca ctaggggacg ctgcacgcag
      121 tccccccgcg cccctcctcc tgcccggcgc gccgctcgac cccgcggagg cgggagcgcg
      181 ggagcacaga cgcggggcga gcgcagggag cgcgcagcgg tcctgtcccc cgcgggagcg
      241 cggctgcagg gccgagccgg ggcggtgggt gggcaggcgt ctgtcttagc ctgcgcatct
      301 gccagcgcgc tggcggaggt ccccggggat gcgagcagtg gcggcttggc gggccgggtc
      361 cggagcgccg cggaggccgg ccgcgtacgc tccgccctct gtggcccgga cccaatctcc
      421 agggactaaa aatattgccc ggaggctcct gagcggaatc agatcgcgtt aagtaggacg
      481 caggctgagg tgacagagct tttcagcacc agggccggaa gagcagactc cagaacgcgg
      541 tcccgcccac gcgcgttcag gagctagcgt cctccctcct ccagcaggag tgtgcctggt
      601 gtcagtatga agctgaaaaa gcaggtgaca gtgtgcgggg ctgctatctt ctgtgtggcc
      661 gtcttttccc tgtacctaat gctggaccga gtgcagcatg atcctgccag acaccagaat
      721 ggtgggaact tccccaggag ccaaatttct gtgctacaga accggatcga acagctggaa
      781 cagctgctgg aagaaaacca tgagatcata agccatatca aggactctgt gctggaactg
      841 acagccaatg cggagggccc accagccctg ctgccctacc acacagccaa cggctcctgg
      901 gctgtgctcc ccgagccccg gcccagcttc ttctctgtat cccctgagga ctgccagttt
      961 gctttggggg gccggggtca gaagccagag ctacagatgt taactgtgtc tgaggatttg
     1021 ccgtttgaca atgtggaggg cggcgtgtgg aggcaaggct tcgacatctc ctacagccca
     1081 aatgactggg atgctgaaga cctgcaggtg tttgtggtgc ctcactccca caatgatcca
     1141 ggctggatca agacttttga caagtactac acggaacaaa cccaacacat cctcaacagc
     1201 atggtgtcca agctgcagga agatccccga cggcgctttc tctgggcaga agtctccttc
     1261 ttcgccaagt ggtgggacaa catcagtgcc cagaaaaggg cagcagttcg aaggctggtg
     1321 ggaaatgggc agctggaaat tgcaacgggt ggatgggtga tgccagatga ggccaactcc
     1381 cattactttg ccctggtcga ccagctcatc gagggacacc agtggctgga gagaaacctg
     1441 ggtgcaactc ctcgctcggg ctgggcagtg gacccctttg gacacagctc caccatgcct
     1501 tacctgctgc gccgtgccaa cctgaccagc atgctaattc agagggtgca ttacgccatc
     1561 aagaagcact ttgcggccac tcacagcctg gagttcatgt ggaggcagac atgggattca
     1621 gactccagca cagacatctt ctgccacatg atgcccttct acagctacga cgtcccacac
     1681 acctgtggcc ctgatcccaa gatctgctgc cagtttgatt tcaaacgtct gccgggtggg
     1741 agaatcaatt gtccttggaa ggtgccgccg cgggctatca cagaggccaa cgtggcagac
     1801 agggcagccc tgctcctgga ccagtaccgg aagaagtccc ggctgtttcg aagcagtgtc
     1861 ctccttgtgc cgctgggtga tgacttccga tatgacaagc cccaggaatg ggatgcccag
     1921 ttcttcaact atcaacggct ctttgacttc ctcaacagca agccggagtt ccacgtacag
     1981 gcacagtttg ggaccctctc tgagtatttt gatgccctgt ataagaggac aggagtggag
     2041 cctggtgccc ggcctccagg gtttcctgtg ctgagtgggg acttcttctc ctatgctgac
     2101 cgggaggacc actactggac aggctattac acttcccggc ctttctataa gagcttggac
     2161 cgcgtgctag aaactcacct tcgtggggca gaggttctat acagcctggc tttggcgcat
     2221 gcccgccgtt ctggactgac tggccagtat ccgctgtctg attacgctgt cctgacggaa
     2281 gctcgtcgta cactgggcct cttccagcac cacgatgcca tcaccggaac tgccaaggag
     2341 gcagttgtag tagactatgg ggtcaggttg ctgcgttccc tggtcagcct aaagcaggtc
     2401 atcatcaatg ctgcccacta cctggtgctg ggggacaagg agacctacag ctttgaccct
     2461 agggcaccct tcctccaaat ggatgacagt cgagtaagtc acgatgccct gcctgagcgc
     2521 acggtgatcc gtctggactc ctcacccagg tttgtggtgg tctttaaccc actggaacag
     2581 gagcggctca gtgtggtgtc cctgctggtc aactcacccc gagtgcgagt gctttcagag
     2641 gagggtcagc ccttgtctgt gcagatcagt gtgcagtgga gctccgccac caacatggtc
     2701 cccgatgtct accaggtgtc agtgcctgtc cgcctgccag ccctgggcct gggtgtgctg
     2761 cagctgcagc cagatctcga tggaccctac acactgcagt cttcggtgca tgtctacctg
     2821 aacggcgtga aactgtctgt cagcaggcaa acaacattcc ctctccgtgt tgtggactcg
     2881 ggcaccagtg acttcgccat cagcaatcga tacatgcagg tctggttctc cggccttact
     2941 gggcttctca agagcgtccg acgtgtggac gaagagcagg aacagcaggt ggacatgaag
     3001 ctcttcgtct atggaacccg cacatccaag gataagagtg gtgcctacct cttcctgcct
     3061 gataacgagg ctaagcccta tgtccctaag aaacctcctg tgctgcgcgt caccgaaggc
     3121 cctttcttct cagaggtggc tgcgtattat gagcactttc accaagtgat tcgactttac
     3181 aacctgccag gggtagaggg gctgtctctg gacgtgtcgt tccaggtgga catcagggac
     3241 tacgtgaaca aggagctagc cctgcgcatc cacacagaca tcgacagcca gggcactttc
     3301 ttcacagacc tcaatggctt tcaggtacag ccccggaagt atctgaagaa gttgcccctg
     3361 caggctaatt tctaccctat gccagtcatg gcctacatcc aggattccca gaggcgcctc
     3421 acgctgcaca ctgctcaggc tctgggtgtc tccagcctcg gcaatggcca gctggaggtg
     3481 atcttggacc gaaggctaat gcaggatgac aaccggggac taggccaagg gctcaaagac
     3541 aacaagatca cctgcaacca tttccgcctc ctgttagaac gtcgaaccct gatgagccct
     3601 gaggtccaac aggagcgctc tacaagctac ccgtccctcc tcagccacat gacttccatg
     3661 tacctcaaca cacctcctct ggtcttaccg gtggccaaga gggagagcac cagccccact
     3721 ctgcactctt tccaccctct ggcttctccg ttgccctgcg atttccatct gctcaatctg
     3781 cgcatgctcc ccgccgagga caccttgccc gcggctgatg ctgctctcat cctacaccgc
     3841 aagggttttg actgtggcct tgaagccaag aacctgggct tcaactgtac cacaagccaa
     3901 ggcaagctgg ccctggggag cctcttccat ggcctggatg tgctattcct gcagcccacc
     3961 tctttgactt tgctataccc tctggcctcg ccctccaaca gcactgacat ctctctggag
     4021 cccatggaga tcagcacctt ccgcctgcgc ttgggttagg ttagggcttc ttgtggcctg
     4081 aagacgaagt tcatccacaa agactgcctc ctaacaccaa gaccgagttg gaccagccac
     4141 actgagtatc acattctgcc tcagaactga cagaccatgc tctgccctta cgttgtctat
     4201 tgctgcttct gtgtttgggc cagcccttac atcagcagac ggcagataca gtgggacagg
     4261 gagaggaggc ccttcccttg ggttgtaagt agctgcccag ctgggcacgg cttaggttcc
     4321 atccttttcc cacaatggga tctaggaaga gcggggacaa acagaagagg tcagggaggc
     4381 tgaggggaac aacctcgcac caggtgactg gagttatgac cgtgctctgt ggggtgatag
     4441 gggccccaca gtgctggtat gagggtacag gtgcagggtg attctgggag atgaggggta
     4501 ggtacctgtt attagtggag taaaggcgtg gaggagtccc tgtttctcct gagagcctaa
     4561 aggctttgtt gctctctgtt ctggctctgc tctaagtgct gctgggcctt tatgccctgg
     4621 ctaggggctg ctgggtggca ggaagggctt gctggacact ccaggccgag gccacagagc
     4681 acttgaggta ttcgtgccag ttttcagctg ctcatttggt gttgatttgt ggcagggtag
     4741 ggagtgtctc cacctgacct gcttctttat ctcacacacc agtctcccta caagttccca
     4801 ttgccgggac cctggcagtg ttcctttccc tagaagggaa acggagcttc caagacccct
     4861 atgcttgggc atcttgggaa agcaatccca tgctggatcc cccggcaggt tcaccgtgtt
     4921 ccatctgccc ggtgtgtgga caaggaagac agagataaaa ttaggaggca tgtgcttcga
     4981 tgagcctccg gttttgcttc actcgataga gaatctgtct ataaacaata agatttggta
     5041 aaagcgaagt ctcatcctta tgaaaacgta gtaagccaag ttagaaagaa gcgccatgat
     5101 ctagagaaag gtctctgtca ccagttacta aggcacagcg cagccattcc cctgagagtc
     5161 agaagctggc cggtggcatg ctggtactta agggtgtcct ggtgtcacta acccatactc
     5221 cagatggaga caagaattat aattgccact gttttaaaac cataagctac ctaagaaacc
     5281 tgcgtcagcc aaagacccag caaggctttc tatgagttgc ccagtgaaga ctggttctcc
     5341 caaaatcagc ccataaaaac aatgtcattc ccacgagatt ggatactttt tggaattctg
     5401 cagatttggc gttatctgga ggatgacagg ctgaggatgt gaagtagttc tgaatggcag
     5461 tggtgatgtg tggccggtga cactgaggcg gccacaggca ggtgtcttat cagagttctc
     5521 aaaggacttg gactcttctg ccagtgtgaa ttcagctgcc atgagaggtc aggtcagaca
     5581 gacctaggca catagaaatt tagtatatga tttcaagtgc aggggaggga gatgaagtat
     5641 ttaatagtgc tttgagacaa ctagctatct gtgagacttc tatctcggtt tcaaaaacaa
     5701 aataaaacca aaaaacccta gggctagagg ggaaaaaaaa aaacaaaaca acaaaatcat
     5761 catcatcatc accatcgtca tcatcatcgt catcatcatc atcatcatca tcagcccact
     5821 atgtacctct gactgtgctg gaactctcta tgtaaaccac gctggcctgg aaatcaccaa
     5881 gatactcacc cgcctctgcc tcctaaatgc tgggactaaa ggcttgtaca cctggaaaga
     5941 aaaaatattt ttatacccgt tgtaggaaaa aggcttttct agacataacg tgaaaccgaa
     6001 tacataatgg gggaaagaca tacacacaca cacacacaca aagcttgaga gcatgctata
     6061 ggaaacaggt taaatcaata caggtgcgtg ggtgggagag catgtgtgtg agtaccttca
     6121 ttgcaggaga aagtgttttg acttctcaga gaacggcacc agggtctgtc cagcagtcac
     6181 ccaaagattc agtagtgaca gggttgagtt cttttttttt ttttttccgg agctggggac
     6241 tgaacctcta ctgctgagct aaatccccag cccccagggt tgagttctct tgcaggtcct
     6301 ccagagtttt tgctgccagg ctcagaccac atggcttcct attcatgtct tggtgacaga
     6361 aataaggtga agcttagaga gcacttatca tagagtgggg gttgtggata agctcctcag
     6421 tgtgagcata aacatggtag aaagcctacg gaaacactcg gacagcaagt gttgtttgct
     6481 ggtctgtggt ttgtaatcaa atgatagggg acactgtgaa cccctaggaa ctttgcagaa
     6541 taaaggatat tctttggagg tcaga
//
LOCUS       NM_001012168            1605 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus TUB like protein 2 (Tulp2), transcript variant
            14, mRNA.
ACCESSION   NM_001012168 XM_341859
VERSION     NM_001012168.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC084696.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341859.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1605
                     /gene="Tulp2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
     exon            1..120
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    78..80
                     /gene="Tulp2"
                     /note="upstream in-frame stop codon"
     CDS             90..1550
                     /gene="Tulp2"
                     /note="isoform 12 is encoded by transcript variant 14;
                     tubby-related protein 2; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 12"
                     /protein_id="NP_001012168.1"
                     /db_xref="GeneID:361576"
                     /db_xref="RGD:1310551"
                     /translation="MPNTPPHDSLGVGSPFLQENVPQAHLPSGAHSALVTMSYVGDGS
                     GERAPLLSPRGAVYTRGNGPAVRHLCWLPDSSDSDVEEVTMEDIPVISRPPKTHLANR
                     RRGWLASPGPGISEEEEVEPKDARVEDKTPSPDPDPTENSDRVHGDSASCNMEENTAK
                     KNIETASGIGDEDPEKKEATESTETNNALVASKVLQGDGDTSNHSAWNMTCPMPRTPG
                     PRLGEDMEAYVLLPAPREHMVQCRIVRNKHGVDKGMFPSYYLYLEAEDGVAVRSSPLG
                     HFLLAGRKRKRSKTSNYLISLDPKDMSRNGNNFVGKVRSNVLGTKFTIFDNGVNPERN
                     YWIPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDQDSILS
                     RVQKGARHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQF
                     GRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     misc_feature    <138..>497
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    <138..>497
                     /gene="Tulp2"
                     /note="Tubby N-terminal; Region: Tub_N; pfam16322"
                     /db_xref="CDD:465092"
     misc_feature    783..1532
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     misc_feature    783..1532
                     /gene="Tulp2"
                     /note="Tub family; Region: Tub; pfam01167"
                     /db_xref="CDD:460094"
     exon            121..258
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..426
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..599
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..917
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1030
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1145
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1244
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1416
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1576
                     /gene="Tulp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacagagca gtagcaccct gcagaacagt gtgggtgcat ctgaaaagct gagctcctgc
       61 atgtcatggg actatcctga gctgctgcta tgcctaacac acctccccat gactccctag
      121 gtgttgggag ccctttcctc caggagaacg taccacaggc acatctgccc tcaggggcac
      181 acagtgccct tgtcaccatg agctatgtcg gagatgggag tggtgagcgg gcccctctac
      241 tgtcacccag aggagcagta tacactcggg gcaatgggcc tgcggtccgc catctctgct
      301 ggctcccaga cagctccgat tcagatgtgg aggaagtgac catggaagac attcctgtca
      361 tctcccgacc tcccaagacg cacctggcaa accgacgcag gggctggtta gcctccccag
      421 gacccgggat cagtgaagag gaagaggttg aacccaagga tgccagagtt gaagacaaga
      481 cacccagccc agacccagac cctacagaaa actctgatag agttcatgga gactcggcat
      541 cctgcaatat ggaggaaaac acagccaaaa agaatataga aacagcctct ggcattgggg
      601 atgaagaccc ggagaagaaa gaggccacag agtctacaga gacaaacaat gccctagtgg
      661 catccaaggt cttgcaagga gatggtgaca ccagtaacca cagtgcttgg aacatgacct
      721 gccccatgcc tcgcactcca ggtcctcggc tcggggagga catggaagct tacgtgttgc
      781 tccctgcacc ccgagaacac atggtgcagt gccgcatcgt ccgaaacaag catggagtgg
      841 acaagggcat gttcccttcc tactacctct acctggaggc agaggatggt gtagcagtac
      901 gctccagccc tttggggcat ttccttctgg ctgggcggaa aaggaaacga agcaaaactt
      961 caaattacct catctccctg gaccccaaag acatgtctcg caatgggaac aactttgtag
     1021 gcaaagttag atctaatgtc ttgggcacga aattcaccat ctttgataat ggggtgaacc
     1081 ctgagcgtaa ctactggatt ccagacagtg cccggatcag agaggagttg ggagttgtat
     1141 gttatgagac caatgtcttg ggattcaggg ggcctcggaa aatgaccgtg atcctcccag
     1201 gaatggacag ccggaagcag aggatgaaag tacaaccaca aaatgatcag gattcaatac
     1261 tgagtcgcgt acagaaaggc gctagacatg ggctgctcct actgcagaac aaggccccat
     1321 cgtggagcga cgaaagcggc gcatacgtac tcaattttca tggtcgcgtc acgcgggctt
     1381 ctgtcaagaa cttccagata gtgcacccgg atgaaccgga ccacctggtg ctccagtttg
     1441 gccgtgtagc accaaacata ttcacgatgg atttccgata tcctctttgc ccgctccaag
     1501 ccttcgccat ctgcttatcc agtttcgatg ggaaactggc gtgtgagtaa ctgaataaaa
     1561 taccatccct caccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_053929               1746 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 7 member 9 (Slc7a9),
            transcript variant 4, mRNA.
ACCESSION   NM_053929
VERSION     NM_053929.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Shigeta,Y., Kanai,Y., Chairoungdua,A., Ahmed,N., Sakamoto,S.,
            Matsuo,H., Kim,D.K., Fujimura,M., Anzai,N., Mizoguchi,K., Ueda,T.,
            Akakura,K., Ichikawa,T., Ito,H. and Endou,H.
  TITLE     A novel missense mutation of SLC7A9 frequent in Japanese cystinuria
            cases affecting the C-terminus of the transporter
  JOURNAL   Kidney Int 69 (7), 1198-1206 (2006)
   PUBMED   16609684
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Kwak,J.O., Kim,H.W., Jung,S.M., Song,J.H., Hong,S.B., Oh,K.J.,
            Ko,C.B. and Cha,S.H.
  TITLE     Co-localization and interaction of b0,+-type amino acid transporter
            1 (BAT1) with caveolin-1 in rat kidney
  JOURNAL   J Nephrol 18 (6), 681-689 (2005)
   PUBMED   16358225
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Feliubadalo,L., Font,M., Purroy,J., Rousaud,F., Estivill,X.,
            Nunes,V., Golomb,E., Centola,M., Aksentijevich,I., Kreiss,Y.,
            Goldman,B., Pras,M., Kastner,D.L., Pras,E., Gasparini,P.,
            Bisceglia,L., Beccia,E., Gallucci,M., de Sanctis,L., Ponzone,A.,
            Rizzoni,G.F., Zelante,L., Bassi,M.T., George,A.L. Jr., Manzoni,M.,
            De Grandi,A., Riboni,M., Endsley,J.K., Ballabio,A., Borsani,G.,
            Reig,N., Fernandez,E., Estevez,R., Pineda,M., Torrents,D.,
            Camps,M., Lloberas,J., Zorzano,A. and Palacin,M.
  CONSRTM   International Cystinuria Consortium
  TITLE     Non-type I cystinuria caused by mutations in SLC7A9, encoding a
            subunit (bo,+AT) of rBAT
  JOURNAL   Nat Genet 23 (1), 52-57 (1999)
   PUBMED   10471498
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB029559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029559.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1746
                     /gene="Slc7a9"
                     /note="solute carrier family 7 member 9"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
     exon            1..36
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            37..144
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            145..256
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    161..163
                     /gene="Slc7a9"
                     /note="upstream in-frame stop codon"
     CDS             170..1633
                     /gene="Slc7a9"
                     /note="b(0,+)AT; solute carrier family 7 (amino acid
                     transporter light chain, bo,+ system), member 9;
                     glycoprotein-associated amino acid transporter b0,+AT1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 9; solute carrier family 7
                     (glycoprotein-associated amino acid transporter light
                     chain, bo,+ system), member 9"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_446381.1"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
                     /translation="MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAIL
                     LITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSV
                     GSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIF
                     YFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE"
     misc_feature    170..238
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    206..1621
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    206..1621
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    221..223
                     /gene="Slc7a9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P82252.1); phosphorylation site"
     misc_feature    263..334
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    356..421
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    500..580
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    611..676
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    677..748
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    821..883
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    923..991
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1076..1144
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1223..1279
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1280..1342
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1400..1462
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1472..1519
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     exon            257..404
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            405..647
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            648..773
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            774..873
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            874..918
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1042
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1146
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1243
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1393
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1568
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1739
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggatctag acacagggta ccaccatcac ctctctacaa gagtctttct acgtatccca
       61 ggttggcttg acttgctgaa tagcccaggc tggccctgaa tttatcattt ttctacctca
      121 actacctcag tgctgggagt tcagcccctg gaactcacag tgagcaagga tggaggagac
      181 aagcccgagg agacggagag aggatgagaa gtccgtccac agtacagagc ccaagaccac
      241 aagtctccag aaagaggtgg gtcttctcag tggtatctgt atcattgtgg gcaccatcat
      301 cggctccggg atcttcatct cccccaagtc tgtgctggcc aacacagaat ccgtggggcc
      361 ctgtctcatc atatgggcag cctgtggagt cctggctaca ctgggcgccc tgtgctttgc
      421 agagcttggc acaatgatca ccaagtcagg gggtgagtac ccctatctga tggaggcctt
      481 cggccccatc cctgcctacc tcttctcctg gaccagcctg attgtcatga agccctcatc
      541 cttcgccatc atctgcctca gcttttcaga gtatgtgtgt gcggcctttt acttaggctg
      601 caggcctcct gctgtggtag tgaaactcct ggctgctgct gccatcttgc ttatcactac
      661 agtgaatgcg ctgagcgtgc ggcttggcag ctatgtgcag aatgtcttca cggcagccaa
      721 gctggtgatc gtcgccatca tcatcatcag cggactggtc ctcctggcgc aaggaaatgt
      781 taagaacttt cagaattctt ttgagggttc acagacctct gtgggctcca tcagcctggc
      841 attttacaac ggactctggg cctacgatgg gtggaaccaa cttaactaca tcactgaaga
      901 gcttagaaac ccttacagaa acctgcccat ggccattgtc attgggatcc ctctggtgac
      961 agtatgctac atcctcatga atattgctta cttcacagtg atgaccccaa cggagctctt
     1021 gcagtcccag gctgtggctg tgaccttcgg agaccgtgtt ctctatccgg catcttgggt
     1081 agtcccactt tttgtggcat tttcaaccat tggtgctgcg aatgggacct gctttacggc
     1141 gggcaggctc atctatgtgg cgggccggga aggccacatg cttaaagtgc tatcctacat
     1201 cagtgtcaag cgcctcactc cggcccctgc cctcgtattc tatggcataa tagccatcat
     1261 ttacatcatc cccggggaca tcaactcctt agtcaattat ttcagttttg ctgcatggct
     1321 cttttatggc atgacaatcc taggactcgt tgtgatgaga ttcacaagga aagacctaga
     1381 gaggcccatc aaggtgccca tcttcatccc tatcattgtg attctcgtat ctgttttctt
     1441 gatcctggcc cccatcatca gttcgccagc ctgggaatat ctctactgcg tgttgttcat
     1501 actgagtgga cttatatttt acttcctttt tgtccactac aagttcagat gggcccagaa
     1561 aatctccagg ccgatcacca agcacctgca gatgctgatg gaagttgtcc caccagagaa
     1621 ggacccagag taaaaggccc atcactcgta gcccaaagct gtgatcaatt tatttttgta
     1681 agcaattatt tgtggttatt tcttcctggt gtttttctta atgaaaacat gtattcagaa
     1741 aaaaaa
//
LOCUS       NM_001438182            1777 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus UDP-GlcNAc:betaGal
            beta-1,3-N-acetylglucosaminyltransferase 8 (B3gnt8), transcript
            variant 1, mRNA.
ACCESSION   NM_001438182 XM_063261364
VERSION     NM_001438182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Ishida,H., Togayachi,A., Sakai,T., Iwai,T., Hiruma,T., Sato,T.,
            Okubo,R., Inaba,N., Kudo,T., Gotoh,M., Shoda,J., Tanaka,N. and
            Narimatsu,H.
  TITLE     A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which
            synthesizes poly-N-acetyllactosamine, is dramatically upregulated
            in colon cancer
  JOURNAL   FEBS Lett 579 (1), 71-78 (2005)
   PUBMED   15620693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063261364.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2500783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000001.1  90263836-90264021
            187-410             JAXUCZ010000001.1  90264314-90264537
            411-1777            JAXUCZ010000001.1  90264926-90266292
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1777
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /db_xref="GeneID:308440"
                     /db_xref="RGD:1305374"
     exon            1..186
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     exon            187..410
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    368..370
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="upstream in-frame stop codon"
     exon            411..1777
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1612
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="UDP-Gal:betaGal beta 1,3-galactosyltransferase
                     polypeptide 7"
                     /codon_start=1
                     /product="UDP-GlcNAc:betaGal
                     beta-1,3-N-acetylglucosaminyltransferase 8"
                     /protein_id="NP_001425111.1"
                     /db_xref="GeneID:308440"
                     /db_xref="RGD:1305374"
                     /translation="MRCRKCQLCLSALLTLLGLKVYIEWTSESWLKKAEPRGALPSPT
                     PPSAEPTLPTNLSARLGQTGPLSSAYWNQQQRQLGVLPSSDCQTWGSVAASEILDFIL
                     YPQDLRRFLLSAACRSFPLWLPAGEGSPVASCSDKDVPYLLLAVKSEPGHFAARQAVR
                     ETWGSPVAGTRLLFLLGSPLGMGGPDLTSLVTWESRRYGDLLLWDFLDVPYNRTLKDL
                     LLLTWLSHHCPKVSFVLQVQDNAFVHIPALLEHLQALPPTWARSLYLGEVFTQAKPLR
                     KPGGPFYVPKTFFEGDYPAYASGGGYVISGRLAPWLLQAAARVAPFPFDDVYTGFCFR
                     ALGLAPRAHPGFLTAWPAERTRDPCAVRGLLLVHPVSPQDTIWLWRHLWVPELRC"
     misc_feature    902..1465
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
     misc_feature    902..1465
                     /gene="B3gnt8"
                     /gene_synonym="B3galt7"
                     /note="Galactosyltransferase; Region: Galactosyl_T;
                     cl21608"
                     /db_xref="CDD:473923"
ORIGIN      
        1 agctggatgg aggtggaagg gactgctggt ggctcctgca caagttggag gaggtgcagg
       61 ccctaactag ggggttctct cagtgcacct cacttcatcg ccttctattg ctctcgtgtg
      121 gccccccctt gcctcctcgc tctccctgga cttttcctct ctgggtcctc ctccgagcac
      181 tccctgtctc accagaaaac cagccctaac tcgccaggac gcgtctccct gtctgcctcc
      241 ccttcccggc cccgccccgg ctcctcccgg ccccaggggc cctctcgccc gcccctccag
      301 actcgcagcg cgggctgggc cggcagccga ggacgcacag cttcgaagag ggagtccggg
      361 cagagcttga cccgaggacc ccccagagct ggcggaagct ggactcagag ccccaccagt
      421 ggccctttcc ctgggccggg tcatgcgttg ccgcaagtgc cagctctgcc tgtcagcact
      481 gctcacactc ctgggcctca aagtatacat cgagtggaca tctgagtcct ggcttaaaaa
      541 ggctgaaccc cggggcgctc tgcccagtcc aacgccacca agtgctgagc ccaccttgcc
      601 caccaacctc tcagcacgcc tgggtcagac tggcccactg tcctctgctt attggaacca
      661 gcagcagcgg caactgggcg tcctgccgag ttcggactgt cagacttggg ggagtgttgc
      721 tgcctcagag atcttggact tcatcctgta cccccaagac cttcggcgct tcttgctgtc
      781 agcagcctgt aggagcttcc cgctatggct gcctgcagga gaaggcagcc cggtggccag
      841 ctgctctgat aaggatgtac cctacttgct actggctgtc aaatcagaac caggacactt
      901 tgcagcaagg caggctgtga gggagacctg gggcagccca gttgctggga cccggttact
      961 cttcctgctg gggtccccac taggaatggg ggggcctgac ctaacatcac tggtgacgtg
     1021 ggagagccgg cgctatggtg acctactgct ctgggacttc ctggatgttc cctacaaccg
     1081 gacactgaaa gacctgctgc tgctgacctg gctgagccac cactgcccca aggtcagttt
     1141 cgtcctgcag gttcaggaca atgcctttgt ccacatccca gccctgctgg agcacctgca
     1201 ggctctgcca cctacctggg cccgcagcct ctacctgggt gaggtcttca cccaggccaa
     1261 accacttcgc aagcccggag gacccttcta tgtgccgaag accttctttg aaggtgacta
     1321 cccagcctat gcaagtgggg gtggctacgt catctcgggg cgcctggctc cctggctgct
     1381 gcaggcagca gcccgagtag cgcccttccc ctttgatgat gtctacactg gtttctgctt
     1441 ccgtgccctg ggcttagcgc cccgtgccca tccaggcttc ctcacagcct ggccagcaga
     1501 gcgtaccagg gacccctgcg ctgtacgagg cctgctgctg gtgcatccag tcagccccca
     1561 ggacaccatt tggctctgga gacatctgtg ggttccagag ctccggtgct gatccccaga
     1621 gacaagctgg ggtggtggtg ggggtgcggg tgagggtgct gacctggcct gagtccctcc
     1681 caaacccttc ccagccaaga atgggcaggc cagacaaggt ggcagactat gttcatctac
     1741 tttctgaatt tgaaaaagtg tgtccttcct actctga
//
LOCUS       NM_001134630             690 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 196 (Ccdc196),
            transcript variant 1, mRNA.
ACCESSION   NM_001134630 XM_001080862 XM_576055
VERSION     NM_001134630.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473947.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_576055.2, XM_001080862.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..690
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="coiled-coil domain containing 196"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
     exon            1..121
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    57..59
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="upstream in-frame stop codon"
     CDS             75..602
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative coiled-coil domain-containing protein 196"
                     /codon_start=1
                     /product="putative coiled-coil domain-containing protein
                     196 isoform 1"
                     /protein_id="NP_001128102.1"
                     /db_xref="GeneID:500678"
                     /db_xref="RGD:1562540"
                     /translation="MTSGSNSSESGLSSKRNPKTYDNYLKELNEDLKLRKQELLEMLK
                     PLEDKNNLLLQKLMANLEEKQRSLQIMRQIMAGRGGDESSVEELIKEAQEMKQNLEKQ
                     QRKIKWVKYEEQPNILQGFHDKVIEVKIEALRNYEKTNDFELSLYLQHDFETKQEALK
                     LLRPQEALFSEVNAR"
     exon            122..274
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            275..371
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            372..431
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
     exon            571..690
                     /gene="Ccdc196"
                     /gene_synonym="RGD1562540"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtcttaact gcacagggaa aggaggcaca tagtttccag aaggcctctt tattgttagg
       61 cgtttccctt caagatgaca agtggctcaa actcttcaga atctggtttg tcctcaaaaa
      121 ggaatcctaa aacatatgac aactacttga aagaattgaa cgaggactta aagttaagga
      181 agcaggaact tctagagatg ctgaaacctc tggaagataa gaacaatctc ttattgcaga
      241 agttaatggc taacttggag gaaaagcaga ggagtctgca gatcatgagg cagatcatgg
      301 ccgggagggg aggtgatgaa tcttcagtcg aggagcttat taaggaagcc caggagatga
      361 agcagaacct ggaaaagcaa cagaggaaaa taaaatgggt caaatatgag gagcaaccca
      421 acatccttca gggctttcat gacaaagtga ttgaggtgaa aattgaagcc ctgaggaact
      481 acgagaagac caatgacttc gagttatccc tgtacctaca acacgatttt gagacaaagc
      541 aagaagcttt gaagcttctg aggcctcagg aggctctttt ttctgaagtc aatgccagat
      601 gaagctctga aggattagaa ggctttcact acatttgctt tggacagatg cgaagactag
      661 gtacggcctt tctgttcact aaaatctctc
//
LOCUS       NM_001438176            3243 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus cysteinyl-tRNA synthetase 1 (Cars1), transcript
            variant 1, mRNA.
ACCESSION   NM_001438176 XM_006230713
VERSION     NM_001438176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3243)
  AUTHORS   Liu,C., Gamper,H., Shtivelband,S., Hauenstein,S., Perona,J.J. and
            Hou,Y.M.
  TITLE     Kinetic quality control of anticodon recognition by a eukaryotic
            aminoacyl-tRNA synthetase
  JOURNAL   J Mol Biol 367 (4), 1063-1078 (2007)
   PUBMED   17303165
REFERENCE   2  (bases 1 to 3243)
  AUTHORS   Davidson,E., Caffarella,J., Vitseva,O., Hou,Y.M. and King,M.P.
  TITLE     Isolation of two cDNAs encoding functional human cytoplasmic
            cysteinyl-tRNA synthetase
  JOURNAL   Biol Chem 382 (3), 399-406 (2001)
   PUBMED   11347887
REFERENCE   3  (bases 1 to 3243)
  AUTHORS   Kim,J.E., Kim,K.H., Lee,S.W., Seol,W., Shiba,K. and Kim,S.
  TITLE     An elongation factor-associating domain is inserted into human
            cysteinyl-tRNA synthetase by alternative splicing
  JOURNAL   Nucleic Acids Res 28 (15), 2866-2872 (2000)
   PUBMED   10908348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006230713.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.4215.1,
                                           SRR26643299.5214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000001.1  208225271-208225345 c
            76-324              JAXUCZ010000001.1  208218705-208218953 c
            325-416             JAXUCZ010000001.1  208214606-208214697 c
            417-505             JAXUCZ010000001.1  208213181-208213269 c
            506-602             JAXUCZ010000001.1  208212543-208212639 c
            603-701             JAXUCZ010000001.1  208211830-208211928 c
            702-851             JAXUCZ010000001.1  208210555-208210704 c
            852-992             JAXUCZ010000001.1  208203165-208203305 c
            993-1081            JAXUCZ010000001.1  208202131-208202219 c
            1082-1203           JAXUCZ010000001.1  208200700-208200821 c
            1204-1316           JAXUCZ010000001.1  208198197-208198309 c
            1317-1445           JAXUCZ010000001.1  208197477-208197605 c
            1446-1575           JAXUCZ010000001.1  208197027-208197156 c
            1576-1679           JAXUCZ010000001.1  208196840-208196943 c
            1680-1777           JAXUCZ010000001.1  208196410-208196507 c
            1778-1967           JAXUCZ010000001.1  208195983-208196172 c
            1968-2036           JAXUCZ010000001.1  208195315-208195383 c
            2037-2118           JAXUCZ010000001.1  208191756-208191837 c
            2119-2199           JAXUCZ010000001.1  208188271-208188351 c
            2200-2267           JAXUCZ010000001.1  208187401-208187468 c
            2268-2327           JAXUCZ010000001.1  208185304-208185363 c
            2328-2411           JAXUCZ010000001.1  208184784-208184867 c
            2412-3243           JAXUCZ010000001.1  208183092-208183923 c
FEATURES             Location/Qualifiers
     source          1..3243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3243
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA synthetase 1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
     exon            1..75
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    39..41
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="upstream in-frame stop codon"
     CDS             51..2546
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /EC_number="6.1.1.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cysteinyl-tRNA synthetase, cytoplasmic; cysteine--tRNA
                     ligase, cytoplasmic"
                     /codon_start=1
                     /product="cysteine--tRNA ligase, cytoplasmic isoform 1"
                     /protein_id="NP_001425105.1"
                     /db_xref="GeneID:293638"
                     /db_xref="RGD:1310747"
                     /translation="MAGSSAEQAADYRSILSISDEAARVQALDQHLSTRSYIQGYSLS
                     QADVDVFRQFSAPPADSRLFHVARWFRHIEALLGGPQGRGEPCRLQASKGRRVQPQWS
                     PPAGTEPCRLRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDIL
                     RRVLRDYFQYDVFYCMNITDIDDKIIRRARQNYLFEQYREQKPSAAQLLKDVGDAMKP
                     FSVKLSETTDPDKRQMLERIQNSVKLATEPLEQAVHSNPSGEEVDSRVQVLLEEAKDL
                     LSDWLDSTGGSEVTDNSIFSKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNF
                     VQKIVDNGYGYASNGSVYFDTAKFAASEKHSYGKLVPEAVGDQKALQEGEGDLSISAD
                     RLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGSLLGASMDIHGGGF
                     DLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS
                     ARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFMNEFFLNVKDILRAPVDITGQFEKW
                     EAEEVELNKNFYDKKTAVHEALCDNIDTRTVMEEMRALVSQCNLYMAARKAARRRPNR
                     ALLENIAMYLTHMLKIFGAIEEENPLGFPVGGPGTNLNLESTVMPYLQVLSEFREGVR
                     KIAREKKVLEVLQLSDALRDDILPELGVRFEDHEGLPTVVKLVDRDTLLKEKEEKKRA
                     EEEKRRKKEEAARKKQEQEAAKLAKMKTPPSEMFRSETDKYSKFDENGLPTHDTEGKE
                     LSKGQTKKLKKLFEAQEKVYKEYLQQLQNSSLQ"
     misc_feature    60..278
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="Glutathione S-transferase C-terminal-like, alpha
                     helical domain of Cysteinyl-tRNA synthetase from higher
                     eukaryotes; Region: GST_C_CysRS_N; cd10310"
                     /db_xref="CDD:198343"
     misc_feature    60..278
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="Glutathione S-transferase C-terminal-like, alpha
                     helical domain of Cysteinyl-tRNA synthetase from higher
                     eukaryotes; Region: GST_C_CysRS_N; cd10310"
                     /db_xref="CDD:198343"
     misc_feature    order(63..71,75..92,96..101,120..122,129..131,147..152)
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="putative protein interface 1 [polypeptide binding];
                     other site"
                     /db_xref="CDD:198343"
     misc_feature    order(63..71,75..92,96..101,120..122,129..131,147..152)
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="putative protein interface 1 [polypeptide binding];
                     other site"
                     /db_xref="CDD:198343"
     misc_feature    order(144..158,240..245,249..254,264..266,273..278)
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="putative protein interface 2 [polypeptide binding];
                     other site"
                     /db_xref="CDD:198343"
     misc_feature    order(144..158,240..245,249..254,264..266,273..278)
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="putative protein interface 2 [polypeptide binding];
                     other site"
                     /db_xref="CDD:198343"
     misc_feature    321..2534
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     misc_feature    321..2534
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /note="cysteinyl-tRNA-synthetase; Provisional; Region:
                     PTZ00399"
                     /db_xref="CDD:240402"
     exon            76..324
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            325..416
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            417..505
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            506..602
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            603..701
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            702..851
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            852..992
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1081
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1203
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1316
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1445
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1575
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1679
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1777
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1967
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2036
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2118
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2199
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2267
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2327
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2411
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..3243
                     /gene="Cars1"
                     /gene_synonym="Cars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattctgga aagcgtctgt ggcggcagac gcgggtcttg attcccagtg atggcaggtt
       61 cctccgcgga gcaggctgct gactacaggt ccattctgag cattagtgac gaggcagcca
      121 gggtgcaggc cctggaccaa cacctcagca cgcgtagcta tatccagggg tactccctat
      181 cgcaggcaga cgtggacgtg ttcaggcagt tctctgcccc tcccgctgac tcaaggctct
      241 tccacgtggc tcggtggttc aggcacatag aagcgctcct gggtggcccc caaggcagag
      301 gcgagccctg caggctccaa gcaagtaaag gccggcgagt gcagcctcag tggtcccctc
      361 cagcagggac tgagccctgc cggctccgcc tatacaatag cctcacccgg aacaaggatg
      421 tatttatacc tcaagatggg aagaaggtga cgtggtactg ttgcgggccg actgtctatg
      481 atgcgtctca catgggacat gccaggtcct acatctcttt cgatatcctg cggagggtgc
      541 tgagggatta cttccagtat gatgtctttt actgcatgaa catcacagac attgatgata
      601 agatcatcag gagggcgcgg cagaactacc tgtttgagca gtatcgggag cagaaacctt
      661 cggctgccca gcttctgaag gatgttggtg atgccatgaa gccattctca gtcaagttaa
      721 gtgagacaac agaccctgac aagaggcaga tgctggagag gatccagaac tctgtgaagc
      781 ttgccacaga accactggaa caggctgtgc attccaaccc ctctggagag gaagtagaca
      841 gccgtgtaca ggtgttgctg gaggaagcaa aggacttgct ctctgactgg ctggattcta
      901 caggtggcag tgaggtgact gacaactcta ttttctccaa actgcccaag ttctgggaag
      961 aagagttcca caaagacatg gaagccctga atgttctccc tcctgatgtc ctgacccgtg
     1021 tcagtgaata tgtgccggaa attgtgaact tcgtccagaa gattgtggac aacggttatg
     1081 gctatgcttc aaatgggtct gtctacttcg acacagccaa gttcgctgct agtgaaaagc
     1141 actcctatgg caagctggtg cctgaggctg ttggggatca gaaagcactt caggaagggg
     1201 aaggtgatct gagcatctct gctgaccgcc ttagtgagaa acgctctccc aatgacttcg
     1261 ccttgtggaa ggcctccaag ccaggagagc catcctggcc ttgcccctgg ggaaagggtc
     1321 gtccaggatg gcacatagag tgctccgcta tggcaggctc gctcctggga gcctcaatgg
     1381 acattcatgg tggaggcttt gacctccgct tcccccacca tgacaatgag ctggcacagt
     1441 cagaggccta ctttgagaat gactgctggg tcaggtactt cttgcacacg ggccacttga
     1501 caatagcagg ctgcaagatg tccaagtcac tgaaaaactt catcaccatc aaagatgcct
     1561 tgaagaagca ctcagcacgg cagctgcggc tggctttcct catgcactcc tggaaagaca
     1621 cactggacta ttccagcaac actatggagt ctgcacttca gtatgaaaag ttcatgaatg
     1681 aatttttctt aaacgtgaaa gacatcctcc gagcccctgt ggacatcact ggccagtttg
     1741 aaaagtggga agccgaagaa gtggagctca ataagaactt ctatgacaag aagaccgcag
     1801 ttcatgaagc cctgtgtgat aacattgaca cccgtactgt catggaggag atgcgggctt
     1861 tggtcagtca gtgcaacctc tacatggcag ccaggaaggc cgcaaggagg aggcccaaca
     1921 gggctctgct ggaaaacatt gccatgtacc tcacccacat gctgaagatc tttggagcca
     1981 tagaggagga gaaccccctg ggtttcccgg ttggtgggcc tggaaccaac ctgaatctcg
     2041 agtctacagt catgccctac ctgcaggtat tatcggaatt cagggagggt gtgcgaaaga
     2101 ttgcccgaga gaaaaaagtc cttgaggttc tgcagctcag tgatgccctc cgggatgaca
     2161 tcctgcctga gcttggggtg cggtttgaag accacgaagg actgccaaca gtggtgaagt
     2221 tggtggacag agacacctta ctgaaagaga aggaagaaaa gaaaagggct gaagaagaga
     2281 agaggaggaa gaaagaggag gcggccagga agaaacagga gcaagaagca gcaaagctgg
     2341 ccaagatgaa gacgccaccc agtgagatgt tccgctcaga aaccgacaag tattctaagt
     2401 ttgatgaaaa tggtctgcct acccacgaca ctgaaggcaa agagctgagc aagggccaga
     2461 ccaagaagtt gaagaagctc tttgaagctc aggagaaagt gtacaaggag tatctgcaac
     2521 agttgcagaa tagcagcctc cagtgatacc accgcagccc agaaggggtc cctgccagcc
     2581 tggccgacat ggactaggcc acacggctca ggcccgccct catcatgttt acagctgctc
     2641 tcacacctga atcaggcaga gtggtagcag ctctgggaca ctggtaataa attcttctga
     2701 accaccggca aggcccggtc tgccctctca gcactggggc gagctggcct acaggtgcct
     2761 gctcagcagc ttgggactta ggcctcctgg tcagttgagc cccttcagcc agcctgccgg
     2821 aggaatttcc ctcacatcgg cgggccgagc taatctctgc tgtgttggca cgtttggtgg
     2881 tattggagta ggaaaaaggc cgactcagcc caacggatcc ccctgagccc cagacaaaag
     2941 ccactcagtt gtctgtctgg ctctgatgaa cacacactgc aggtttccca gagcaactga
     3001 caaagtggca gcaggacagt tgccctgtgg gatggggctc tggcaagctg cctgcgactg
     3061 ccgttatgac agcaagccca gatcagcacc acggcttgta agataaggga ttctctagtc
     3121 caacctgaag tgtttctcct ctccacctgc tcctgcctgt ttgttcgccc ttgccaagaa
     3181 tcagcaccta tgctgaatgt gtctagcctt ctctaatgat taaaaagaaa agaaagaaag
     3241 gta
//
LOCUS       NM_001438183            3981 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus taxilin beta (Txlnb), transcript variant 1, mRNA.
ACCESSION   NM_001438183 XM_006227657
VERSION     NM_001438183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006227657.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.103.1, SRR26643289.97.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000001.1  14224769-14224859
            92-537              JAXUCZ010000001.1  14227624-14228069
            538-629             JAXUCZ010000001.1  14235494-14235585
            630-800             JAXUCZ010000001.1  14241775-14241945
            801-995             JAXUCZ010000001.1  14250713-14250907
            996-1115            JAXUCZ010000001.1  14252937-14253056
            1116-1190           JAXUCZ010000001.1  14257014-14257088
            1191-1283           JAXUCZ010000001.1  14262873-14262965
            1284-1379           JAXUCZ010000001.1  14265928-14266023
            1380-3981           JAXUCZ010000001.1  14267236-14269837
FEATURES             Location/Qualifiers
     source          1..3981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..3981
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="taxilin beta"
                     /db_xref="GeneID:308622"
                     /db_xref="RGD:1307979"
     exon            1..91
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    75..77
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="upstream in-frame stop codon"
     exon            92..537
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2162
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /codon_start=1
                     /product="beta-taxilin"
                     /protein_id="NP_001425112.1"
                     /db_xref="GeneID:308622"
                     /db_xref="RGD:1307979"
                     /translation="METNHPDQLSVEQPNPPGDSSPLNQNVPGKQDVQQSSTSGQAAE
                     QEASPHPEKGDHDISEELSRQLEDIINMYGSAASPTGKEGTSETKEQPQNTEAPDNED
                     GDYEETTEETDREPTAPEEPATVKGPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQA
                     PEEKLDFLFKKYAELLDEHRTEQKKLKLLLKQQAQTQREKDQLQSEHNRAILARSKLE
                     SLCRELQRHNKTLKEETLQRAREEEEKRKEITSHFQSTLTDIQTQIEQQSERNMKLCQ
                     ENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEEAQELMQEAEERHRRE
                     KEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMD
                     NTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIQRLENLCRAL
                     QEERKELYKKIRDAKMSEKEDQVQHTSDEEPESKVSEDKQMDVEAANGVQNAVKNLAT
                     AFAILHHPEFTPDQSRERQPAVNGPPGGSDLTHQHTEPAHLNHPNPSSVSGSPQPPVG
                     SQAGSEGGCEAAPAPTACCTPAEAELQSQGLSAGNPPDPKPQKPEAKASGQVPLSPAQ
                     GSLAVVEAKCDISPSPESERDPAVVPGCESKEHPPPEVPDIPLGPNTGLPREPDACLN
                     GVE"
     misc_feature    540..1463
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="Myosin-like coiled-coil protein; Region: Taxilin;
                     pfam09728"
                     /db_xref="CDD:462861"
     misc_feature    540..1463
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="Myosin-like coiled-coil protein; Region: Taxilin;
                     pfam09728"
                     /db_xref="CDD:462861"
     misc_feature    <1683..2135
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    <1683..2135
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     exon            538..629
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            630..800
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            801..995
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1115
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1190
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1283
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1379
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..3981
                     /gene="Txlnb"
                     /gene_synonym="RGD1307979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacacagc ccgcgcctgt ccctgctgct gctgctctct ctgccacctc tttcctctcc
       61 tttctcttcc cgcttagctc ccttccttct ggtcctgctc ccatatggag actaatcatc
      121 ctgatcagct ctcagtagaa cagccaaatc ccccagggga tagctctcca ctcaatcaaa
      181 acgtcccagg aaaacaagat gttcaacagt cctcaacctc aggccaagca gcagagcaag
      241 aggcaagccc gcatcctgag aagggagacc acgatatctc tgaagagctg agccgacaac
      301 tggaagacat tataaacatg tacgggtctg ctgccagtcc cacaggaaaa gagggcacct
      361 ccgaaactaa ggagcagccc caaaacacag aggcaccgga caatgaggat ggcgactatg
      421 aggaaaccac tgaagagaca gacagagaac ccactgctcc tgaagagcct gccacagtca
      481 aagggcctgt cagtaataaa gagcaaaagc tggaaaagaa aatcctgaaa ggattaggta
      541 aagaagctaa cttgctcatg caaaatctaa acaagctgca ggcacccgaa gaaaagcttg
      601 attttttatt caagaagtat gctgaattgc tggatgaaca tcgcactgag caaaagaaac
      661 tgaagctcct actgaaacag caggcgcaaa cgcagagaga gaaggaccag ttgcagagtg
      721 agcacaacag agccatcctg gctcgaagca aactcgagag tctgtgtcgg gagctacaga
      781 ggcataataa gacactgaag gaagagaccc tccaacgggc gcgcgaggaa gaagagaaga
      841 ggaaagagat cacgagtcat tttcagagta ccctgacaga tatccagacc cagatagaac
      901 agcagagcga gcgcaatatg aagctctgcc aggagaacac agagctcgca gaaaaactga
      961 aaagcatcat cgaccagtac gagctcagag aggagcatct ggacaaaata ttcaaacacc
     1021 gagaactgca gcagaagctg gtggatgcga aacttgaaga ggcccaagaa ctgatgcagg
     1081 aagcagaaga gcggcacaga cgggagaagg aatatttgct gaaccaggca gcagagtgga
     1141 aacttcaggc caaagtgcta aaggagcagg agaccgtgct gcaggctcag cttactctct
     1201 actcgggaag gtttgaggag ttccagagta cactgacaaa aagtaatgaa gtgtttgcca
     1261 ctttcaagca ggaaatggat aatacgacaa agaaaatgaa gaagctggag aaggacacgg
     1321 ccacatggaa agcccgattt gagaattgta acaaagccct gctggacatg atcgaagaga
     1381 aagccctgcg agctaaggaa tacgagtgtt tcgtgatgaa aatccagagg ctggagaacc
     1441 tgtgtcgtgc tttacaagaa gagagaaagg aactctacaa gaaaatcaga gacgcaaaaa
     1501 tgtccgaaaa ggaagaccag gttcagcaca cctctgacga agagccagag tcaaaagtct
     1561 cggaagataa acagatggat gtagaggcag ccaacggcgt tcaaaatgct gtgaaaaatc
     1621 tggccacagc tttcgccatc cttcatcatc cagagttcac cccagaccaa tcaagggaaa
     1681 gacaaccggc agtgaatggc cctccaggtg gaagtgacct cacccaccag cataccgaac
     1741 cagcccattt aaaccatccc aacccttcca gtgtttcagg gagtcctcag ccccctgtgg
     1801 gttctcaggc tggttctgag gggggctgtg aggctgctcc tgcccctaca gcctgctgta
     1861 cccctgcaga ggcagagctc caaagccagg gtctctctgc tgggaacccc ccagacccga
     1921 agccgcagaa gccagaggca aaagcttctg gtcaggtccc actgtcccca gcccagggct
     1981 ccctagccgt agtagaggca aaatgtgata tttcgccgtc cccagagagt gagagagatc
     2041 ctgctgttgt acctgggtgt gagtctaagg aacatccccc accagaagtc ccagacatcc
     2101 cgctaggccc taacaccggg ctccccagag agcccgacgc ctgtctgaac ggagtagagt
     2161 aagcctcatc gattcttctg tctgttcacc tgcagaaaat ctgtgaaaga aacttctagt
     2221 cctagaaaac acatacacac gtattttcat acatgtatat aacgttatca tataagcata
     2281 tttcactcct tacagatttt tctctattgc aagatattta catgcttgta aaaaaattct
     2341 ctctttctta cactctggat tacagtagat taaaactgta tgaatcagaa acagcacatg
     2401 ctgtacacaa ggaggacctc aggacgcctt taacagcaaa ggggaaacca caaacaggtg
     2461 gttctgatct gctaatgctt ctgattctca cagctagctt cctcccagct tcccagcatc
     2521 ccacctcccg ggatgaagca gcctcctcct ggctatctgt gagaaagtgg ttggaaataa
     2581 agaatctaag atttgagggg ttgcgtatac tcagcataga ggaagctggc cctggcccct
     2641 gcttctttgg ctactgattt ctcaggaaaa cacttcttgt tgtctctaac cttgtgtttt
     2701 atctcaaagc atctatttct tccgagttcc ctcctttgtg tcaatgtgta tgcctagctc
     2761 acgtctctat tactgttaag taaaatatat ttttccgaaa caggaatcca cacgacctct
     2821 caataggagt aataaggctt acaaagccaa cacattttct gctctaagga gttttgaaca
     2881 ggcagaaata caaaattaaa aaggggcaga cgaggactcc atagatgtca aaagctagaa
     2941 gcaattggga ttacccaaac aagttttata ctcgcattat tgacaaaaaa aaaatcctct
     3001 actaacactg acagcataca ttactctgcc taggctaaaa gaagactata ctaacaaaac
     3061 aggaagaagt gggaaggagg gagacagaag gagtataagg aatggactgt ctaatctaac
     3121 tctacgttaa gaagttgaac acaggtagaa atatggatga aggaaggctc ttgaaaactc
     3181 atccaggaag tcattcttca gtggtgcatg gtggctgttt gccaatgcac ataaggagct
     3241 ggtaggcagt agccatatgt taaaggaatt ataaaactgt ataaaatttg tttgaagtag
     3301 acagtaaggg aaagaacaaa aataccattt ggggaataaa aaaaaaaaaa aaaccagggg
     3361 aaaaagcacg tcgttatttg agaactcatg tgttttcaga ggctttgcat attataaccg
     3421 cacgggtatc cagccaagtt caacaccact ggaaattaga cattcaatta actcaaagtc
     3481 aaatattcac tatactaatc ccttctctct gtttacagga gaaaggacag agtaggatca
     3541 tcacagttaa gtctcaatcc aaaaactcag gaagacaaac aggcaggagg cactgacatc
     3601 caataaatta ggaattctaa tatccaatgt ttattatttt catccaagag aatttcacag
     3661 caacatatca ctcataactg tgtgtacctt tggcacagtt tcataggcta taccttccct
     3721 gaaacctgta aagctttaat ataggctttg ggagacttat tttaatagtc aaagaatgtt
     3781 ttattatagt actttgtgtt caaacttggc cttactaatc ataacaactc ataagatctg
     3841 aaagcagaaa ttacatctct tctttatgaa gttcatataa ctatttttag agatgccaaa
     3901 tctttctaga aacactggaa ttattgcttt ctaaatgtaa taacataatg tttataccaa
     3961 ttaaaaaggc atttcttcca a
//
LOCUS       NM_031008               3258 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit alpha 2
            (Ap2a2), transcript variant 2, mRNA.
ACCESSION   NM_031008
VERSION     NM_031008.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Capella,P., Asensio,J., Troncoso,M., Sosa,M.A. and Seltzer,A.M.
  TITLE     Evidence on differential role for alpha 1 and alpha 2 subtypes of
            AP-2 adaptin in the central nervous system
  JOURNAL   Neurosci Lett 808, 137282 (2023)
   PUBMED   37127089
  REMARK    GeneRIF: Evidence on differential role for alpha 1 and alpha 2
            subtypes of AP-2 adaptin in the central nervous system.
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Marcello,E., Saraceno,C., Musardo,S., Vara,H., de la Fuente,A.G.,
            Pelucchi,S., Di Marino,D., Borroni,B., Tramontano,A.,
            Perez-Otano,I., Padovani,A., Giustetto,M., Gardoni,F. and Di
            Luca,M.
  TITLE     Endocytosis of synaptic ADAM10 in neuronal plasticity and
            Alzheimer's disease
  JOURNAL   J Clin Invest 123 (6), 2523-2538 (2013)
   PUBMED   23676497
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Duncker,S.V., Franz,C., Kuhn,S., Schulte,U., Campanelli,D.,
            Brandt,N., Hirt,B., Fakler,B., Blin,N., Ruth,P., Engel,J.,
            Marcotti,W., Zimmermann,U. and Knipper,M.
  TITLE     Otoferlin couples to clathrin-mediated endocytosis in mature
            cochlear inner hair cells
  JOURNAL   J Neurosci 33 (22), 9508-9519 (2013)
   PUBMED   23719817
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Voglmaier,S.M., Keen,J.H., Murphy,J.E., Ferris,C.D.,
            Prestwich,G.D., Snyder,S.H. and Theibert,A.B.
  TITLE     Inositol hexakisphosphate receptor identified as the clathrin
            assembly protein AP-2
  JOURNAL   Biochem Biophys Res Commun 187 (1), 158-163 (1992)
   PUBMED   1325787
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Bahler,M., Klein,R.L., Wang,J.K., Benfenati,F. and Greengard,P.
  TITLE     A novel synaptic vesicle-associated phosphoprotein: SVAPP-120
  JOURNAL   J Neurochem 57 (2), 423-430 (1991)
   PUBMED   2072093
  REMARK    Erratum:[J Neurochem 1991 Dec;57(6):2155]
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Tucker,K.L., Nathanson,K. and Kirchhausen,T.
  TITLE     Sequence of the rat alpha c large chain of the clathrin associated
            protein complex AP-2
  JOURNAL   Nucleic Acids Res 18 (17), 5306 (1990)
   PUBMED   2402467
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081786.1.
            
            On Dec 8, 2007 this sequence version replaced NM_031008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081786.1, SRR8487227.332266.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3258
                     /gene="Ap2a2"
                     /note="adaptor related protein complex 2 subunit alpha 2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
     exon            1..147
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2900
                     /gene="Ap2a2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adaptor protein complex AP-2, alpha 2 subunit; AP-2
                     complex subunit alpha-2; alpha2-adaptin; alpha-adaptin C;
                     100 kDa coated vesicle protein C; adaptor protein complex
                     AP-2 subunit alpha-2; adaptor-related protein complex 2,
                     alpha 2 subunit; adapter-related protein complex 2 alpha-2
                     subunit; clathrin assembly protein complex 2 alpha-C large
                     chain; plasma membrane adaptor HA2/AP2 adaptin alpha C
                     subunit; adapter-related protein complex 2 subunit
                     alpha-2"
                     /codon_start=1
                     /product="AP-2 complex subunit alpha-2 isoform 2"
                     /protein_id="NP_112270.2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
                     /translation="MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKF
                     KGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLV
                     NSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDT
                     MDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKN
                     PEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDPAV
                     RGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQL
                     GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDL
                     LYAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLI
                     RIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFG
                     NLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSD
                     SQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPST
                     VTDLEETKRERSIDVNGGPEPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGG
                     LLVDVFSDSASAVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFI
                     FYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTE
                     APVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFK
                     AKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQ
                     MYRLTLRTSKDTVSQRLCELLSEQF"
     misc_feature    165..1853
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    165..1853
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    1074..1145
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1074..1145
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1185..1274
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1185..1274
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1302..1382
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1302..1382
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1926..2126
                     /gene="Ap2a2"
                     /note="propagated from UniProtKB/Swiss-Prot (P18484.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2229..2540
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2229..2540
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2556..2882
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     misc_feature    2556..2882
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     exon            148..216
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..359
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..553
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..683
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..785
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..894
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1045
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1214
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1352
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1535
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1633
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1865
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2039
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2203
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2286
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2376
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2500
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2617
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2687
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2822
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3230
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctccag ggctactcgg cgtgacggcc gcgcccgttc tgttccagcc cgccgccgag
       61 gccgctcccg ggtcgcaaag atgccggccg tatccaaggg ggaggggatg cgaggcctag
      121 cggtcttcat ctccgatatc cgtaactgta aaagtaaaga agctgaaata aagaggataa
      181 ataaggagct ggcaaatatt agatcaaaat ttaaaggtga caaggctctt gatggctaca
      241 gtaagaagaa gtatgtctgc aagttactct tcatctttct ccttggtcat gacattgact
      301 ttggacacat ggaagctgtg aatcttctga gctcaaacag atacacggaa aagcagatcg
      361 gctacctttt catctctgta ttggtgaatt caaatagtga actgatccgg ttgattaaca
      421 atgccatcaa gaatgacctg gccagccgca atcctacatt tatgggtctg gccctgcact
      481 gcatcgccaa tgtgggtagc cgtgagatgg cagaggcctt cgctggagag atccccaaga
      541 tcctggtggc aggagatacc atggacagtg tgaagcagag cgcagccctg tgcttgttgc
      601 gcctgtacag gacgtcacct gacctagttc ctatgggcga ctggacatcc cgtgtggtac
      661 acctcctcaa tgaccagcac ttgggtgtag tgactgccgc aactagcctc atcaccacac
      721 tggcccagaa gaatcctgag gagttcaaga cctctgtctc tctagctgtc tctcgactga
      781 gcagaattgt gacgtccgcg tcaacagatc ttcaggatta tacttactac tttgtcccgg
      841 ctccttggct gtcagtcaaa cttctgagac tgctgcagtg ctacccaccc ccagaagacc
      901 ctgcggtgcg tggccgcctg actgagtgct tggagaccat cctgaataag gcccaggagc
      961 cccccaagtc caagaaagtc cagcattcaa atgccaagaa cgctgtgctg tttgaggcca
     1021 tcagcctcat catccaccat gacagtgagc ccaacctcct ggtccgtgcc tgcaaccagc
     1081 tgggccagtt cctgcagcat cgggagacaa acctgcgcta cctggctctg gagagcatgt
     1141 gcacactggc cagctctgag ttctctcacg aggctgtcaa gacccacatc gagactgtca
     1201 tcaatgcctt gaagacggaa cgagatgtga gtgtgcggca gcgggcagtg gacctgctct
     1261 acgccatgtg cgaccgaagc aacgcccagc agattgtggc tgagatgctg agctacctag
     1321 aaacagctga ctactccatc cgggaggaaa ttgtgctgaa ggtggccatc cttgctgaga
     1381 agtatgcagt ggactacact tggtatgtgg acaccatcct caacctcatc cgcattgcag
     1441 gcgactatgt gagcgaagag gtgtggtacc gcgtcatcca gattgtcatc aatcgcgatg
     1501 atgtgcaggg ttatgctgcc aagacggtgt ttgaggcatt gcaggctcca gcatgtcatg
     1561 agaacttggt caaagtgggc ggctacatcc tgggcgagtt tggaaacttg atagcgggag
     1621 acccacgatc cagccctctg atccagttca acctgctcca ctccaagttc cacttgtgca
     1681 gcgtccccac tcgggcactc ctgctgtcca cctacatcaa gttcgtgaac ctctttccag
     1741 aggtaaaggc taccattcag gacgtgctgc gcagtgacag ccaactgaag aacgcagatg
     1801 tggagctgca gcagcgggct gtggagtacc tgcgactgag tactgttgcc agcactgata
     1861 tcctggcaac tgtcctggaa gaaatgccac ccttccctga gcgtgagtcc tccatcttgg
     1921 ccaagctgaa gaagaagaag ggcccaagca cagtgactga cctggaggag accaagcgtg
     1981 agcgaagcat cgatgtgaat gggggccccg aacccgttcc agccagcacc agtgctgcgt
     2041 ccacaccttc tccatcagca gacctgctgg gtctgggggc cgttccccct gctcccacag
     2101 ggccccctcc cacctctggc ggtgggttac tggtggacgt gttctcagac tcagcttctg
     2161 cagttgcacc tcttgcaccc ggctctgaag acaactttgc caggtttgtt tgtaaaaaca
     2221 atggtgtgtt gtttgaaaac cagctgcttc aaattggact gaagtcagaa tttcggcaga
     2281 atttaggtcg aatgttcata ttttatggta acaagacctc cacgcagttc ctaaacttca
     2341 ctccaacact aatctgtgct gacgaccttc agactaatct gaacctgcag actaagcccg
     2401 tggacccaac tgtggatggg ggcgcacagg tgcaacaggt ggtcaacatt gagtgtatat
     2461 ctgatttcac agaggcacct gtcctcaaca tccagttcag gtatggtggt accttccaga
     2521 atgtgtctgt taagcttccc atcactctca acaaattttt ccagcccaca gaaatggctt
     2581 ctcaggattt ctttcaacgt tggaagcagt tgagcaatcc acagcaagaa gtgcagaata
     2641 tcttcaaagc aaagcatccg atggacacag aaatcactaa agcgaagatt attggatttg
     2701 gttctgcgct cctggaagaa gttgatccaa accctgcaaa ttttgtgggt gctggcataa
     2761 tacataccaa aaccacccag atcggctgct tgttgcgcct ggagccaaac ctgcaagctc
     2821 agatgtacag actcaccttg cgtaccagca aagacaccgt ctctcagaga ctatgtgaat
     2881 tgctgtcgga acagttctaa tccacagacc agaagatcag gctctttgtt tgtgcgtctc
     2941 tctcgtctct ctcgtttgtc tttgtaccac actgcagata aacacccctt gtctgaaaac
     3001 tgccattcaa ggcacctcca gtcctacacc tacagccagc ccctgggtgt ggagggaatg
     3061 caggacacag tttgagaagg gctgcagcag gcctgccccg tcaaagaagg gtgcctgggc
     3121 ctgggaaatc aaggcagtcc tgtggttcaa cctacaaatt aaagggaaat tagaaatttg
     3181 aacgaaagtg gaaattttgt tcaaatttta ttaaaatgcc actggttcaa aaaaaaaaaa
     3241 aaaaaaaaaa aaaaaaaa
//
LOCUS       NM_001438209            4572 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus ankyrin repeat domain 6 (Ankrd6), transcript
            variant 2, mRNA.
ACCESSION   NM_001438209 XM_017593571
VERSION     NM_001438209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Haribaskar,R., Putz,M., Schupp,B., Skouloudaki,K., Bietenbeck,A.,
            Walz,G. and Schafer,T.
  TITLE     The planar cell polarity (PCP) protein Diversin translocates to the
            nucleus to interact with the transcription factor AF9
  JOURNAL   Biochem Biophys Res Commun 387 (1), 212-217 (2009)
   PUBMED   19591803
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of rat Ankrd6 gene in silico
  JOURNAL   Int J Mol Med 15 (2), 359-363 (2005)
   PUBMED   15647854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 16, 2025 this sequence version replaced XM_017593571.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26755.1,
                                           SRR26643299.22215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000005.1  52139343-52139468   c
            127-390             JAXUCZ010000005.1  52054889-52055152   c
            391-489             JAXUCZ010000005.1  52031828-52031926   c
            490-588             JAXUCZ010000005.1  52023913-52024011   c
            589-687             JAXUCZ010000005.1  52022282-52022380   c
            688-786             JAXUCZ010000005.1  52020533-52020631   c
            787-885             JAXUCZ010000005.1  52019165-52019263   c
            886-984             JAXUCZ010000005.1  52018063-52018161   c
            985-1062            JAXUCZ010000005.1  52017201-52017278   c
            1063-1167           JAXUCZ010000005.1  52013736-52013840   c
            1168-1299           JAXUCZ010000005.1  52012565-52012696   c
            1300-1485           JAXUCZ010000005.1  52012070-52012255   c
            1486-1638           JAXUCZ010000005.1  52010648-52010800   c
            1639-1752           JAXUCZ010000005.1  52004973-52005086   c
            1753-1879           JAXUCZ010000005.1  52003750-52003876   c
            1880-4572           JAXUCZ010000005.1  51999210-52001902   c
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4572
                     /gene="Ankrd6"
                     /note="ankyrin repeat domain 6"
                     /db_xref="GeneID:500430"
                     /db_xref="RGD:1583731"
     exon            1..126
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            127..390
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="Ankrd6"
                     /note="upstream in-frame stop codon"
     CDS             271..2412
                     /gene="Ankrd6"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 6"
                     /protein_id="NP_001425138.1"
                     /db_xref="GeneID:500430"
                     /db_xref="RGD:1583731"
                     /translation="MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRT
                     PLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALD
                     RQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRVL
                     LLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLSAFCSVHEKNQAGDTALHVAAALN
                     HKKVVKILLEAGADTTLVNNAGQTPLETARYHDNPEVALLLTKAPQILRFSRGRSLRK
                     RRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPEKEEARRDCPPASQEPRKD
                     ERRRKSRPEVSALSDPTPAADQQPGHQKNLHGHHHQKKKSRHRCWSPPPPHGFRAYQL
                     YTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEAAVEELRAELGTVQDKVNTKLGHME
                     SKSQHQMCVLDKLMVERLSAERTECLNRLQQHAAAEKQEGEKRQMSLVDELKSWCMLK
                     IQNLELRLSGESRTFRAKSTPSPSDSSPAVDQPVVAAGPGAASDSSSQVVRPKDKALN
                     ATAVPRHQQELLPSDCTGSGLRKVKAPAASRLGDQQTGSCVNRGTQTKKSARGGQTKH
                     RGQQPTASSPSGQQPSAASSDARDASQALELTQYFFEAVSAQMEKWYERKIEEARSQA
                     SQKAQQDEATLKEHIRSLEEEVAKLRTKMHK"
     misc_feature    283..1002
                     /gene="Ankrd6"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    283..1002
                     /gene="Ankrd6"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(391..393,397..399,409..414,421..429,433..438,
                     448..450,457..459,484..486,490..492,496..498,508..513,
                     520..528,532..537,547..549,556..558,583..585,589..591,
                     595..597,607..612,619..627,631..636,646..648,655..657,
                     682..684)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(391..393,397..399,409..414,421..429,433..438,
                     448..450,457..459,484..486,490..492,496..498,508..513,
                     520..528,532..537,547..549,556..558,583..585,589..591,
                     595..597,607..612,619..627,631..636,646..648,655..657,
                     682..684)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    391..486
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    391..486
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    490..585
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    490..585
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    589..684
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    589..684
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    691..783
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    691..783
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(694..696,706..711,718..726,730..735,745..747,
                     754..756,781..783,787..789,793..795,805..810,817..825,
                     829..834,844..846,853..855,880..882,886..888,892..894,
                     904..909,916..924,928..933,943..945,952..954,979..981)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(694..696,706..711,718..726,730..735,745..747,
                     754..756,781..783,787..789,793..795,805..810,817..825,
                     829..834,844..846,853..855,880..882,886..888,892..894,
                     904..909,916..924,928..933,943..945,952..954,979..981)
                     /gene="Ankrd6"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    787..882
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    787..882
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    886..981
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    886..981
                     /gene="Ankrd6"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    <1903..2388
                     /gene="Ankrd6"
                     /note="triacylglycerol lipase; Region: PLN02847"
                     /db_xref="CDD:178439"
     misc_feature    <1903..2388
                     /gene="Ankrd6"
                     /note="triacylglycerol lipase; Region: PLN02847"
                     /db_xref="CDD:178439"
     exon            391..489
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            490..588
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            589..687
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            688..786
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            787..885
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..984
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1062
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1167
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1299
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1485
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1638
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1752
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1879
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..4572
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catacggggc ggggtcctaa ggcatctaga ccacgcgcgg tggagcgtgg ggcgagcggc
       61 tgcgggcagg gagcgcagcg gcccgcgagc tccgtgcgga gcggccggcc ggcgcaggag
      121 caaaagggcc tgaagatgga gtagtaacaa aggcatcccc catgattctc agcacccttc
      181 cctgtggact ccagccccag ccagaggctg catgtggagc tgaagaaact gaccagctgc
      241 tttcctgaga gcccctttct ctcctaattc atgagccagc aggatgcggt cgccgcgctt
      301 tcagaacgcc tgctcatagc tgcgtacaaa ggccaaacag agaatgtggt tcagctcatc
      361 aacaagggtg ccaaggtagc ggttaccaag catggccgga cccccttgca cctcgctgcc
      421 aataagggtc atctttctgt ggtgcagatt ttgctgaagg ctggctgtga cctcgatgta
      481 caagatgatg gggaccagac agccttgcac cgggccactg tggtgggcaa cactgagatc
      541 ctcacagcgc ttatccggga gggatgtgcc ctggacagac aggacaagga tgggaatacg
      601 gccctgcatg aagccgcctg gcatggattc agccagtcag ccaagctgct cgttaaagcc
      661 ggagccaacg tgcttgccag aaacaaggca gggaacacgg ctctgcacct ggcctgccag
      721 aatagtcact cccagagcac acgcgtcctc ctgctgggcg gctcccgggc tgacctcaaa
      781 aataatgcag gggacacctg cttgcacgtg gctgcgcgct ataaccactt gtccgttgtt
      841 agactcctcc tcagtgcttt ctgctctgtt catgaaaaga accaggctgg agacacggcc
      901 ctccatgtgg ccgctgccct aaatcacaag aaggtagtta aaatcctgct ggaagccggt
      961 gctgacacga cccttgtgaa caatgcaggg cagaccccac tggagaccgc ccgctaccac
     1021 gacaatcccg aagttgctct gctcctcacc aaggctcccc agatcttgcg cttcagtcgt
     1081 gggcgaagcc tgaggaaaag gagggagagg ctcaaggaag agaggagggc tcagtctgtg
     1141 cccagagatg aggtggccca gagcaaggga agcgtctcag caggagacac ccccagcagt
     1201 gaacaagctg tacccgaaaa ggaagaagct aggagagatt gcccaccagc ttcccaggag
     1261 ccaagaaagg atgaaaggag gagaaagtca aggccagagg tgtcagcact atctgacccc
     1321 accccagcag cagaccaaca acctggacac caaaagaacc tacatggtca tcaccaccaa
     1381 aaaaagaaga gcagacatcg atgctggtcc ccaccaccgc cccacgggtt cagggcgtac
     1441 cagctctaca cgctgtaccg tggcgaggac gggaaagtga tgcaggcacc aatcaaaggt
     1501 tgtcgctgtg agcctctgat caacaagctg gagaaccagc tggaggcggc tgtggaggag
     1561 ttaagagctg agctgggaac agtgcaggac aaagtgaaca caaagctggg ccacatggag
     1621 agcaagagcc agcaccaaat gtgcgttttg gacaaactga tggtggagcg gctgtcagct
     1681 gagagaacgg aatgtctgaa tcgcctgcag cagcatgcag ctgctgagaa gcaggaggga
     1741 gagaaacgtc agatgtcatt ggtggatgaa ctgaaatcct ggtgtatgtt gaagatccag
     1801 aatctggagt tgagactttc gggagagtct cggaccttta gagctaaatc cacaccatct
     1861 ccctccgact cctctccagc tgtagaccaa ccagtggtag ctgcagggcc gggagcagct
     1921 tccgacagct cctctcaggt tgtgaggccc aaggacaagg cactcaatgc cactgctgtc
     1981 cccagacacc agcaggagct gcttccctct gattgcacag gctccgggtt aaggaaggtc
     2041 aaggccccgg ctgcttccag actgggtgat cagcagactg ggtcctgtgt caaccgaggc
     2101 actcaaacca agaagtctgc gagaggtggg cagaccaagc atcgaggcca acaaccgaca
     2161 gccagcagcc ccagtgggca gcagccatcc gcggcaagca gtgacgcccg agatgcctcg
     2221 caagccctgg agctaaccca gtattttttt gaggctgttt ctgctcagat ggaaaagtgg
     2281 tacgaacgga aaattgaaga agcacgaagc caggccagtc agaaagctca gcaagatgag
     2341 gccacactga aggagcacat caggagtcta gaagaggagg ttgccaagct gcgcacaaag
     2401 atgcacaagt aaaaccagat tctgaagtgg acccagcagg gtttccagct tgataacagc
     2461 aaagtaactg tgtccccgga gttggttgtc atgcacaagg tggatttgcc tttaatagag
     2521 tcactaattg gttgtggaca catacttcgt gctctgaagt tacaaggcct tcactggtta
     2581 aaatgaatcc tgggaagatg tctataaaca gcaagacacc aagaagagga ggtgtgaccc
     2641 acgtctgtga ttcatgaagt gtgtcagaag caaagcagag aactctggga acccagtagc
     2701 cattcacgtc catgccaaca cacctgctgt gcctagacgg tccttctagc agagctggga
     2761 ctcagatgcg ggaagccctc tttctcccat gtaactcaag atgctcatct tttaaagggg
     2821 tgaaaccctt tcaggttgtg aggatataca ctgtaatgac ctcagtgtcc agtgtgtctt
     2881 caagtaagtt taaggatcat ataaaggagt agcaattgct gactgtcaag tgagaagggt
     2941 ttaaaccatt ggtcagttac tgtgattttg gccaaataac tgagcagatt aatggaaaaa
     3001 tattcaccaa acaactccag ccagttacct tagattacct ttctagagtc aagacgtttg
     3061 ttccatgttt tgtaaagaaa tcaggaaata tcacgaaagt ttaattttga attgacttct
     3121 cactgaagaa catcaagccg tcaaaaggcg ttgcctgttt actgagtaag atgtaccaga
     3181 ctgaggtggt gactctatct tggttgggac cttggatttg cctaatcctt tggtacatgg
     3241 aacacggatt atgtctgtct ccacatatgc atagaaacgt atgtttctct aagcctaagg
     3301 acctaataac tactatccat gaattgtaac taaaatgctg ttcattgagc caaagagaag
     3361 tgatctttgc ggaatagtat gcatttatgc cttggtcaag ccaagttctt ccttttgctt
     3421 atagtgacaa tccacggata gacattcgta taaacacgac agggcagata ttgggtatgc
     3481 atcatccagt gagcccaatt atttcctggg accgacctat cctcagcctc ttgggaggta
     3541 cagcccttcc ccattctcct tcaccggagt cctgtcctca gctcacttgc acctgagccc
     3601 tgctatgaca ctacccacaa caaaatgtca ctcactcctg taggatcact ccttattcat
     3661 acagcaaatt attgggaact gcctaatact aagtaagaga tgaaaccccg agttcagcat
     3721 gagttatttt cactattaga atactcatta cctcaagaaa cccttgacaa gaagggcaga
     3781 aatcaactgt aactgaacat caagtctaga ccacagaata tcttagtggc agtgctttga
     3841 tgatatcctc ctacctatga gaagcaggca gcttatcact gtgaatggat gtttttgtca
     3901 agtcattaag cataaagacc aggctattgt ctaaggccag tcagcccctt acccacaggg
     3961 ttgacttctg aggaagtggt ggttggcttg tttttggaag gcttaccgtg tactctagac
     4021 tggctttggt ctcatgacct tcctgtcgca gccacctgag ttgggactaa aggagtgagc
     4081 cccatggcca atcatgtttt gtttgtaaca ccagtgttag gtttgtggca attggtcctc
     4141 agcattgtac agcactgagg atcagctgtg tctttcccct cgtgctgtgt gcaaaaaaca
     4201 aatatcccag ctgtactttt acagataact gctcatacca tacactctca caataggtca
     4261 tgtttcaaac cgaggcctaa aaagtgtcaa cagccgtgaa gaaacatgtt ataaaacagt
     4321 agtgttgcat atcaatgtcc tttttaaaaa acaggtaatt gttagcacat cccttagagt
     4381 gcatactgag catctgtgct ggggtgaaag tgttagtcta gcatcacttt tgatgtggag
     4441 tccaaaatac aggtttttca tgtttagatt tgtgtgtgca aggcatgctg tctaattttt
     4501 ttagtcacct tgaacttgtg tctcctataa gcattaaacg tttgagttct gtcggtatcc
     4561 tactttttta ta
//
LOCUS       NM_001191627            3077 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus fibronectin type III and SPRY domain containing 2
            (Fsd2), transcript variant 1, mRNA.
ACCESSION   NM_001191627 XM_006229440 XM_218860
VERSION     NM_001191627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Apr 16, 2025 this sequence version replaced
            XM_006229440.5, NM_001191627.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223649.1, SRR26643295.2943.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000001.1  144931599-144931704 c
            107-779             JAXUCZ010000001.1  144925538-144926210 c
            780-875             JAXUCZ010000001.1  144925066-144925161 c
            876-1106            JAXUCZ010000001.1  144920011-144920241 c
            1107-1129           JAXUCZ010000001.1  144918936-144918958 c
            1130-1251           JAXUCZ010000001.1  144917084-144917205 c
            1252-1407           JAXUCZ010000001.1  144915160-144915315 c
            1408-1542           JAXUCZ010000001.1  144912887-144913021 c
            1543-1693           JAXUCZ010000001.1  144912038-144912188 c
            1694-1827           JAXUCZ010000001.1  144908442-144908575 c
            1828-1963           JAXUCZ010000001.1  144906298-144906433 c
            1964-2140           JAXUCZ010000001.1  144901612-144901788 c
            2141-3077           JAXUCZ010000001.1  144898501-144899437 c
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3077
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="fibronectin type III and SPRY domain containing 2"
                     /db_xref="GeneID:308779"
                     /db_xref="RGD:1305167"
     exon            1..106
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            107..779
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    123..125
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="upstream in-frame stop codon"
     CDS             153..2393
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /codon_start=1
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2"
                     /protein_id="NP_001178556.1"
                     /db_xref="GeneID:308779"
                     /db_xref="RGD:1305167"
                     /translation="MEEEAGEEPGLGRSTAPRDFHFYHMDLYDSEDRLQLFPGESSRT
                     RREVTQAELTNEPRGAGDSKNLQKEVDALVHLYGLEDEHELGGEFVDEHRLGTLGYPY
                     GMRRRDPGREQRDWGLSGEAAEAEDLCYGVQGPPDQCQDLREAYRYTHGRASEEYECY
                     VIPEEEDEEEPADVFCVTCKTPVRTVEKDFDIHKEHEVTPINKALEHAKDEIHKNMCK
                     LEQQIIEMENFASHLEEVFITVEENFGRQEQNFECHYNEILETLAQKYEEKIQALGEK
                     KKEKLEALYGQLVSCGENLDACRELMETIEEMCHEEKVDFLKDAVAMTDRLGKFLKTK
                     TDVELSAKPEFEDQTLDFSDVEQLMDSINTVPAPSAPVINPQAPNSATGSSVRVCWSL
                     YSDDTVESYQLSYRPVQDSSPGKDQAEFTMTVKETYCSVKNLEPNTQYEFWVIAQNRT
                     GPSPSSEHVVYMTAPSPPSIKTEAIRSCEEAVLICWESGNLNPVDSYTVELIQAETPE
                     ASGVTESVVGIPTCESLIQLQPRHSYTIYVRALNVGGTSARSKPATVHTTGSYFQLNK
                     DTCHPWLTISEDGFTVVRSEKKRSFRRELPPSKAQFSRCVAVMGNLIPVRGRHYWEVE
                     VDEHLDYTVGVACEDVPKQEDLGANRLSWCMRHTFASTRHRYEFLHNGTTPDIRITVA
                     PKKIGVLLDYEDSKLSFFNVDIAQHLYTFSCPLHQFVHPCFSLEKSGGLKICNGISAP
                     KHVTFF"
     misc_feature    759..>1073
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    759..>1073
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    1254..1511
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    1254..1511
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain; Region: FN3; smart00060"
                     /db_xref="CDD:214495"
     misc_feature    order(1254..1256,1458..1460,1503..1505)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1254..1256,1458..1460,1503..1505)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     misc_feature    <1257..>1826
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    <1257..>1826
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; Region: FN3; COG3401"
                     /db_xref="CDD:442628"
     misc_feature    order(1506..1511,1515..1520)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    order(1506..1511,1515..1520)
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     misc_feature    1833..2363
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     misc_feature    1833..2363
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /note="SPRY domain; Region: SPRY; cl02614"
                     /db_xref="CDD:470632"
     exon            780..875
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1106
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1129
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1251
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1407
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1542
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1693
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1827
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1963
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2140
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..3077
                     /gene="Fsd2"
                     /gene_synonym="RGD1305167"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggtcacc gggaagggga gctgaccaga cagaaatcca atttttccag cagaaaccta
       61 ggaccgtgga gttaaaggac acatttatgg acctttaaat gagcaggtct cagaataccc
      121 actgactgac taggaagggc tgttctgtgt caatggagga ggaagcaggg gaggagccgg
      181 ggctggggag atcaacagcc cccagagact tccactttta tcacatggac ctgtatgact
      241 ctgaagatag actgcagctc ttcccaggag aaagcagcag aacccggagg gaagtaaccc
      301 aggctgaact gaccaatgag ccaagagggg caggggacag taagaatctc cagaaggaag
      361 tggacgcgct tgtccattta tacgggcttg aagatgaaca tgagttaggg ggtgaatttg
      421 tggatgaaca cagattgggg actctggggt atccgtacgg gatgaggagg agggatccag
      481 gcagggagca gagagactgg gggcttagtg gtgaggcagc tgaggccgag gacctgtgct
      541 acggagttca aggccctcct gaccaatgcc aagaccttcg ggaagcctac aggtacacac
      601 atggccgcgc cagcgaggaa tatgaatgct acgtcatccc agaggaggaa gatgaggaag
      661 agcctgctga tgtcttctgt gtcacttgca aaactccagt gagaactgtt gagaaggatt
      721 ttgatataca caaggaacac gaagtaaccc caatcaacaa ggctctggaa cacgccaagg
      781 atgaaattca caaaaatatg tgcaaattgg aacagcagat tattgagatg gaaaatttcg
      841 ctagccacct ggaagaagtg ttcatcactg tggaggagaa ttttggaaga caagaacaaa
      901 acttcgagtg ccattacaac gagatcttgg aaaccctcgc tcagaagtat gaagaaaaaa
      961 ttcaagctct gggggagaaa aagaaagaga agctggaagc cctatatgga cagctggtca
     1021 gctgtggaga gaacctcgat gcctgcagag agctgatgga aaccatagag gagatgtgtc
     1081 acgaggaaaa ggttgacttc ttaaaggatg cagtggctat gactgacaga ctggggaaat
     1141 tcctgaagac caagacagac gtggaactct ctgcaaagcc tgagtttgaa gaccagaccc
     1201 tggacttctc ggatgtggaa cagctgatgg actccatcaa taccgttcca gctccctctg
     1261 ctccagtgat aaatccccag gcacccaact cagcaactgg ctcctcggtg cgtgtgtgct
     1321 ggagtttata ctctgatgac accgtggaga gctatcagct gtcctacagg ccggtgcagg
     1381 acagctcacc tggcaaggac caagcagagt tcaccatgac ggtcaaagaa acatattgct
     1441 cagtgaaaaa tcttgagcca aatacccagt atgagttttg ggtcatagct caaaacagga
     1501 ccggccccag cccctctagt gagcacgtag tgtatatgac agccccctct cctccctcta
     1561 taaaaaccga ggcaatcagg agctgtgaag aggccgtgct gatttgctgg gagtctggaa
     1621 acctgaatcc cgtggactcc tacacagtgg agctaatcca ggcagagacg ccagaagcct
     1681 cgggggtaac tgaatctgtt gtaggcatcc caacctgtga atccctgata cagctacagc
     1741 ctagacacag ctacacgatc tacgttcgag ccctgaatgt ggggggcacc agtgccagaa
     1801 gcaagcctgc tacagtacac accacaggaa gctacttcca actgaacaag gacacctgcc
     1861 acccctggct gaccatttct gaagacgggt ttaccgtggt tcgaagtgag aagaagagaa
     1921 gtttcagaag ggagctgcca cccagcaagg cgcagtttag caggtgcgtt gctgtcatgg
     1981 gaaatctaat tccggtccga ggacgccatt actgggaggt ggaggtggat gagcatttgg
     2041 actacactgt tggtgtggcc tgtgaagatg tccctaaaca ggaagacctg ggagcaaacc
     2101 gcttgtcctg gtgcatgagg catacatttg cctccacaag gcaccggtat gagtttctgc
     2161 acaatgggac aactccagac ataaggatca cagttgctcc aaagaagatc ggcgtcctgc
     2221 tagactatga ggactccaag ctgtcctttt tcaacgtgga cattgctcag cacctgtaca
     2281 cgtttagctg cccactccac caatttgtgc atccctgctt ttccttggaa aagtctggag
     2341 gcctaaagat ctgcaatggc atatcagcgc caaagcacgt cactttcttt taggcccttc
     2401 tggtatttct gctttttcct ctgtcctgtc ccacagctgc cctcacctca ccggctgaac
     2461 ctggtattcg aggtgcctgt agccagcagc agctcacgtt actgtcagat gttatgccgg
     2521 agcccatttc acccgatgtg gactcatcct gcgtgctggg ccctgctgat gccaggggag
     2581 cctttatcag aacagcctgt taaatgaggg ctcctgtgga gtcgaatcct tgtagtgtca
     2641 aactgcagtt tgtgctctgt aaagtatttc aagtctccta aacttacaga cccagggaga
     2701 gtatcaggga agtcgtgatg gtgtcagcag cccctgtaca tgtgtgacat tttactgttt
     2761 accaagaaca gactagggaa ggcaagaaac tctcgacaga aaaagaagtc agatgctcat
     2821 cttgaggctg ccgtggtaga ctgaataaga atggttccca ataggctgac acatgggtgg
     2881 gggaggggct gaggtggcac tacttgaaaa ggattagacc tattaggagg tgtggctttg
     2941 tggatcagaa tatacatatg tctcctttcc actactgctc ctgtgacgag tgctgccgtg
     3001 cttcctgcca tgatgataat gggtaaacct ctgaaactgt aagccagcct ccaattacat
     3061 gttgtctttt ttaagca
//
LOCUS       NM_001107457             473 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus kaptin (actin binding protein) (Kptn), transcript
            variant 2, mRNA.
ACCESSION   NM_001107457 XM_001074187 XM_217806
VERSION     NM_001107457.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Baple,E.L., Maroofian,R., Chioza,B.A., Izadi,M., Cross,H.E.,
            Al-Turki,S., Barwick,K., Skrzypiec,A., Pawlak,R., Wagner,K.,
            Coblentz,R., Zainy,T., Patton,M.A., Mansour,S., Rich,P.,
            Qualmann,B., Hurles,M.E., Kessels,M.M. and Crosby,A.H.
  TITLE     Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and
            seizures
  JOURNAL   Am J Hum Genet 94 (1), 87-94 (2014)
   PUBMED   24239382
REFERENCE   3  (bases 1 to 473)
  AUTHORS   Bearer,E.L. and Abraham,M.T.
  TITLE     2E4 (kaptin): a novel actin-associated protein from human blood
            platelets found in lamellipodia and the tips of the stereocilia of
            the inner ear
  JOURNAL   Eur J Cell Biol 78 (2), 117-126 (1999)
   PUBMED   10099934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074187.1, XM_217806.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB734880.1, CB810022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..473
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /note="kaptin (actin binding protein)"
                     /db_xref="GeneID:308107"
                     /db_xref="RGD:1310341"
     exon            1..297
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    24..26
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /note="upstream in-frame stop codon"
     CDS             75..389
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kaptin-like 1; KICSTOR complex protein kaptin"
                     /codon_start=1
                     /product="KICSTOR complex protein kaptin isoform 2"
                     /protein_id="NP_001100927.1"
                     /db_xref="GeneID:308107"
                     /db_xref="RGD:1310341"
                     /translation="MGEAAVAEGPCPLREDSFTRFSSQSNVYGLAGGADGRGELLAAT
                     LKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIK
                     VP"
     exon            298..473
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtatgcgct agtggaggtt ccctgacagg ttggggagca tcgggccagc tgggaccgat
       61 cgcggagggc caggatgggg gaggcggccg tggcagaagg gccctgtcca ctgcgagagg
      121 acagcttcac gcgcttctcg tcgcagagca acgtgtatgg gcttgctgga ggcgccgacg
      181 ggcgagggga gttgctggcc gccactctta aaggcaaggt gctcggcttc cgctatcaag
      241 acctccgaca gaaaatcagg cctgtggcca aagagctgca attcaactac atccccgtgg
      301 atgctgagat cgtctccatc gacactttca acaagtcacc cccaaaacgg ggcctggttg
      361 tgggcatcac ttttataaag gtaccatagc accctccacc tgtccacgtc ctcttcctta
      421 gtccctgtgg atcccaccaa gtctatccca agtgctctga atctacagaa aat
//
LOCUS       NM_001438191            7222 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 7
            (Entpd7), mRNA.
ACCESSION   NM_001438191
VERSION     NM_001438191.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7222)
  AUTHORS   Shi,J.D., Kukar,T., Wang,C.Y., Li,Q.Z., Cruz,P.E.,
            Davoodi-Semiromi,A., Yang,P., Gu,Y., Lian,W., Wu,D.H. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel mammalian
            endo-apyrase (LALP1)
  JOURNAL   J Biol Chem 276 (20), 17474-17478 (2001)
   PUBMED   11278936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2562402.1,
                                           SRR26643429.5703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000001.1  252508595-252508707
            114-216             JAXUCZ010000001.1  252508997-252509099
            217-399             JAXUCZ010000001.1  252509836-252510018
            400-605             JAXUCZ010000001.1  252524321-252524526
            606-756             JAXUCZ010000001.1  252525309-252525459
            757-860             JAXUCZ010000001.1  252532756-252532859
            861-917             JAXUCZ010000001.1  252536328-252536384
            918-1051            JAXUCZ010000001.1  252537274-252537407
            1052-1218           JAXUCZ010000001.1  252540750-252540916
            1219-1543           JAXUCZ010000001.1  252543620-252543944
            1544-1629           JAXUCZ010000001.1  252546651-252546736
            1630-1791           JAXUCZ010000001.1  252548112-252548273
            1792-7222           JAXUCZ010000001.1  252549488-252554918
FEATURES             Location/Qualifiers
     source          1..7222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..7222
                     /gene="Entpd7"
                     /note="ectonucleoside triphosphate diphosphohydrolase 7"
                     /db_xref="GeneID:309390"
                     /db_xref="RGD:1310638"
     exon            1..113
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            114..216
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    197..199
                     /gene="Entpd7"
                     /note="upstream in-frame stop codon"
     CDS             209..2023
                     /gene="Entpd7"
                     /EC_number="3.6.1.-"
                     /note="bifunctional protein NCOAT-like"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     7"
                     /protein_id="NP_001425120.1"
                     /db_xref="GeneID:309390"
                     /db_xref="RGD:1310638"
                     /translation="MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFIPCLLLLL
                     LIMDLRHWTTSLPRDRQYERYLARVGDLEATNTEDPNLSYGLVVDCGSSGSRIFVYFW
                     PRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVP
                     VKKHRETPLYILCTAGMRLLPERQQVAILADLVKDLPLEFDFLFSQSQAEVISGKQEG
                     VYAWIGINFVLGRFDHEDESDADTSVDSASGRRRTVGILDMGGASLQIAYEVPTSASV
                     LPPKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLN
                     KNRLLGQRTGLSPDNPFLDPCLPVGLTDVVERNSQVLHFRGKGDWATCRTMLSPLLAR
                     SNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGM
                     TWSVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYEVLHEGFHFPYDYPNLQTAQLVYD
                     REVQWTLGAILYKTRFLPLRDLRQGGVRQAHGSWFRLSFVYNHYLFFACTLVVLLAIV
                     LYLLRIHRIHRRQTRASAPLDLLWIEQVVPMIGVQVGP"
     misc_feature    452..1801
                     /gene="Entpd7"
                     /note="nucleotide-binding domain (NBD) of the
                     ectonucleoside triphosphate diphosphohydrolase 4
                     (NTPDase4)-like subfamily; Region:
                     ASKHA_NBD_NTPDase4-like; cd24045"
                     /db_xref="CDD:466895"
     misc_feature    452..1801
                     /gene="Entpd7"
                     /note="nucleotide-binding domain (NBD) of the
                     ectonucleoside triphosphate diphosphohydrolase 4
                     (NTPDase4)-like subfamily; Region:
                     ASKHA_NBD_NTPDase4-like; cd24045"
                     /db_xref="CDD:466895"
     exon            217..399
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            400..605
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            606..756
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            757..860
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            861..917
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1051
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1218
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1543
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1629
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1791
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..7222
                     /gene="Entpd7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacgtgg cgccgccggc agccgggcct ccttccggct gtgttggaag ccacggggga
       61 ccgctgagga ccaggccggg ctgtgcagag ggacgagcgg gcctcaggat cccgctgctg
      121 gcttaggaga tgcctgggac taggaggcca ccctctcaga gcaaaaggaa acggaggtga
      181 cagacgtcca gatcactgaa gggaacccat ggctaggatc agtttttcct acctctgccc
      241 agcctcctgg tacttcactg tacccacagt gagcccattt ctccgtcagc gggtggcatt
      301 cttgggactt ttctttattc cctgtctcct tttacttctc ttaatcatgg atttacgaca
      361 ttggaccact tcgttaccac gagataggca gtatgagagg tatctggccc gggtaggaga
      421 cctcgaagcc accaacacag aagacccaaa tctgagttat ggactggtcg tggactgtgg
      481 cagcagcggc tcccggattt ttgtttactt ctggcccagg cataatggga acccccatga
      541 tttgctggac atcaagcaga tgagagaccg aaacagccag cccgtggtta agaaaataaa
      601 gccagggatc tccgcaatgg cagacactcc agaacacgct agcgattacc ttcgacctct
      661 gctgagcttc gctgccgctc atgtgcccgt gaagaagcac agggagacac ctctttacat
      721 cctctgcacg gcgggcatgc ggctgctccc cgagaggcag caggtggcta tcttggcgga
      781 tttagtgaaa gatttgccgt tggagtttga cttcctcttt tcacagtctc aagccgaagt
      841 gatctctggg aagcaggaag gagtttatgc atggattgga atcaactttg ttctgggaag
      901 atttgaccat gaagatgagt cagatgcaga cacttctgtg gactcagcat caggccgcag
      961 gaggacagtg ggaatcctgg acatgggagg agcctcactc caaattgcct acgaagttcc
     1021 tacctcagcc tccgtccttc ctcccaaaca ggaagaagct gccaagatcc tgctggctga
     1081 gttcaacctg ggctgtgatg tgcagcacac ggagcatgtg tacagggttt atgtcactac
     1141 ctttctgggt tttgggggca actttgcccg gcagcgctat gaagatctgg tgctgaatga
     1201 aacgcttaac aaaaacagat tgctgggcca gaggacaggc ctgagtcctg acaatccctt
     1261 tctggacccc tgcctgcccg tgggactcac ggatgtggtg gagaggaaca gccaggtcct
     1321 tcacttccga gggaagggag actgggccac ttgtcggacg atgctaagcc ccctgctagc
     1381 ccgctccaac accagccagg cctcactgaa cggcatttac cagtcaccaa tcgacttcaa
     1441 caacagcgag ttctatggct tctcggagtt tttctactgc acagaggatg tactgcgcat
     1501 cggaggccgc taccatggac cgacatttgc caaggctgct caggattact gtggcatgac
     1561 ttggtcggtg ctagcccaga gattcaagaa tggcctcttt tcttcacatg cagatgagca
     1621 tcgactcaag tatcagtgtt ttaagtcagc ttggatgtat gaagtccttc acgaggggtt
     1681 ccacttcccc tacgactacc caaacctgca gacagcgcag ctggtgtacg accgagaggt
     1741 gcagtggacg ctgggcgcaa ttctgtataa aacccgattc ctgccactca gggacctccg
     1801 gcagggagga gtccggcaag cccacggcag ctggttccgc ctttcttttg tctacaacca
     1861 ctatctcttc tttgcttgta cgctggtggt gcttctggcc atcgtcttgt accttctgcg
     1921 catccacaga attcaccgca gacaaacccg agcctcggct ccactggacc tgctgtggat
     1981 cgagcaagtg gtgccgatga ttggggtgca ggtggggccg tgaggctgga gcggaagtgg
     2041 agaaactcca gttccttcgg attgctgctg ctgctgctgc tgcttactga atccctccac
     2101 tttctcgaac tggcctccga tgctgctttg gcctgtgaat ttctactttt tcactttaat
     2161 ttctttttgg tgcccaggac gggacctctt ctcagaagcc acaatttaac tccgaggagc
     2221 taaatgttga gaggccggtg ctaagcttag cccaaatgaa gcatgcttct cctttatctc
     2281 agaaatctga tccgtttctg ggacgtagca ttttttttcc cccttgctga agcaagtttt
     2341 tgattgggca accggaggca tgattgaaac caacttggat tgactgctac aaagccagag
     2401 gcattccagc aagtgcagtt gcccgttttc tctgtaacag agagatcctt atgtggagat
     2461 ccacagcctt gagtaaggac ccaagatctc tgaggttcag cggaccagat ttcaaggcaa
     2521 ccaaaacgat acagcttcct tgcttacttg acaagccatt ggcgggtgtg ctccgatatc
     2581 gctggcagtg ttgttgactt tgttctatag atctgagacg ttagagcgcc tttgaaatga
     2641 acgacatatt gaagatctga cagtattttt atctgatact tggtctgacc agtatagaag
     2701 acatttccgt gtctatgtgc ctcacaggct gcttgggcat taacgtcgcc ttctgagcct
     2761 taagtgtgct tatagaatgg agaaaccatg atgggaaccg ggacctgggt ttgcctgttt
     2821 cgggttactg tctcacaagc acatagtgtg cagaagcttc aaagtgactt ccctcatttc
     2881 attgctaaat gtgtattttg ggaaggaatg tatttgtttt gttttgtttt aagaaagaat
     2941 agcatcagga gagtgggcaa aggcaataaa tccaaggttt tgctttttgt tttgcttttt
     3001 tttttttttt ttgagacagg gtctctgtag ccctggctgt cctggaattt gctctctaga
     3061 ccaggctagc ctcagactca aactcacaga gacctgcatc ttcctcctga gcactgggat
     3121 taaaggcatg agacatcatg tctggcttaa agccaaagtt cttacttttt tttttttttt
     3181 tttttttttt tttttttgag acgcttgaaa gacagcaaat tctaaacttt ggaataacta
     3241 gataaatctg ccaaggagca acctggccac tttctggatg tctgtcacaa acagctctcc
     3301 cattagtggg gagaggacag ccatattccc gatgtttccc ccactgcctc tcagaaactg
     3361 caggagcctc tcatgtggtc tatggtctat gatcactagc tcctccctgc ccccacggac
     3421 tccttatttc ctggacaaaa ccatgaggcc tgcttgggat tgttcccagg gctgacgcag
     3481 tagtttgatt tcttctttta gggttaagta aggcaggtct catgagccta actttctagg
     3541 taaccaaggc cagccttgaa ctcctgatct tcctgcctcc gttctctttg aagtgctggg
     3601 tttaaaggtg tgtgccacca ggcctggccg gctttccttt cattttgcca aagcctttta
     3661 tttctagggt tagaagacag aagaagaaaa aaggtctaga gaatgaaaaa tgaatatctt
     3721 tgaaaataaa ttccaactgg gaacagaagg aaatgaaatg atttatgaaa tagaggaaag
     3781 agtaaagatg gtcttagggg taaccagtgt gagggtaagg gacccagcca ttaggccagt
     3841 cctcagctat cagcacctct tcctcctcct cttcctcctc ccttcttccc ccacttctcc
     3901 tttctcttct ccttcctccc cattcctctt cttccttctc cttctccccc tcttcttcct
     3961 cctcctttct cctcctcctt ccccctccct cctgctctct tttttttttt tttttttttt
     4021 ttttttgagg cagggtgtca ctgaccccag gctggcctgg ttctcagtgg tcgtcctgcc
     4081 ccagcctccg attacagacg tctgccacca cgtgtgcaca ctaggtgagt gcacacctag
     4141 caaagattct ttcatttcac gtcctttcca ctaggactgc gccattgaca tttctaatgt
     4201 taagacttct cagccgtctc cattctccat cattctcatt ttttaagtcc tgtgagagcc
     4261 tctgcttttt tttttttttt tttttaatgt tgctttaaaa tgttcttact ggccatttgc
     4321 ttcctcaggg gacatttaac ttcatcttgg tttctgtaca gctgtctcgg tgtgttggga
     4381 gagctagtca gagttcctgg gcaggttaac agggaccgta tccctgtgca gctgctgaag
     4441 ctgggggagg ggaggggagc tagtccagtt tgaagctctc attactgaac ttcctctttg
     4501 tcctgaaggt actagaaact accatttgtc aagcacttgt ttgtgtcact cttaagaatg
     4561 tcgtgttctt tattgtatgt ttatctaatc atggcggcag cccttcggat tgatacccct
     4621 acgttctttt tatagttgaa aaaaaatctc aggatgccta tccttattat ttctcaatat
     4681 aaatatattt cttaatttat tttaattagt ctttgagttt ctgtttggtg cactacatcc
     4741 tgtttacttc tttcatatta tgggatccag acttaccttt attaccgtaa gatttcccag
     4801 agttccatgg gttaagaaca agaagggaca gtgttacacg gctgaaagga actgagcgta
     4861 ttgctctcca cttgtccctg tgtgcttacg tcatccccac tgggtagact tcaggtggaa
     4921 tctcattagc cacgtttccc ctgcatctgt tttaggttta tgtttaagca atgaacttaa
     4981 ctttgcacat tttttcctta cccacaacat tccagtaata gaattactat ctgagtgacg
     5041 gacatatgcc tcatagagat ctatctacct cattatagaa catggtggtg attcttggga
     5101 agtttccaga ctgcgatttg tatgtgactc ctttgtagct ggactaggaa ttaagtagta
     5161 gcaatggttg tttcagagcc tcttaaatca gtctcttagt ttatgtttca actcagtccg
     5221 tgggatggca gacttctgca aactcatcaa gattttgttg gcattataaa aattagtatg
     5281 ttcaaaactg aggatgtaaa accaagtttt ggcacctttg actaacaata cagaagaaca
     5341 aacatttgta aacaatgatt aaaatcaaat acttttaggt aatggtctgt attgtgggtg
     5401 gctctgtcct tggcctccta acttggaggt gatctaactg gaaaagctat tataccatag
     5461 gtgggttcct gttgatgccc ggctttctgt ttctgtggga ggcttgtgaa ggttctgttt
     5521 taagccagtt ttgccctgtt gtatatgcca gtggactgtc attgtgtttc atatttcccc
     5581 ttggcctagt atttcatttt ggtttgttaa tacaatcatt tgagggacag aggagactca
     5641 cacaccagct gaccattttc ttctctggaa atctgagcaa taaagagact cttttatatt
     5701 gtaaaatgga gtcattgctc atcctctaag ggcttccagt ttttcaaata tgaaccagat
     5761 cagtgcttcc actgcataaa aatcagagtt gaaaatgttc tgagtcatgg gatgtttagc
     5821 catgcctgca tgccagacaa gcttgaggat gtctctattc ctgagcccct ctttatagca
     5881 ggacagcagc taatagaccc ccaccctcac ctccagccag ctagtctagt actgtaacaa
     5941 aacacctgag atcatttata aagagaaggg ttgctctggg tcacaggtag atgtttaact
     6001 ccgtagtcgc gtgtcccttt gctttggcct gcaatgaagt gtacactgta gcaggcacaa
     6061 gtggtgtagc aaatcggatg cctagctcat ggccaggatg caagaaatga tggagttggg
     6121 attctcgctc ctcctccagt aacttaaaga ccttctagga agctgtggcc acaaggggcc
     6181 catcattccc aataatgtca ccatggggac caagccttta acacatgggc cctggaggac
     6241 attaaatctg tgcacccatg gagcacagcc ctgagttggg ctcctctggt aggaaaggat
     6301 ctgccccttt attagcttcc caggtccgcc tctgccagcg ggaatcctga atatgccaac
     6361 tgcttgtatt tctgcttcaa gttctccttc cgcactgtcc attcagttga agctgtaagt
     6421 attcgccacg tctcctccag agtgtctatc tttagcacag tctctgtggt ggctacgctg
     6481 tctgccactg tgacccccga ccttaaggac aaaggctgca gcccctccct gcttcaggtg
     6541 gctgaagctg ctcttaacat gaattacatt aagaatttca tcagccagga ggtgaaaaaa
     6601 gaattttgtg gaattcttaa attttgtgga ctaattctta atattctgat acacgtggag
     6661 ttctagaaaa tgtgcagtgt attagagtgt cgacagtcat ctttctgtgg ctctgtgtgg
     6721 cctatgccca tatataaccc accatttacc caagaccagg agggctgcaa gtaaaactgc
     6781 tattctaaat ccccaattat cagggaacca acttcactct gggcagccac taataaccct
     6841 gttgcagcag acgcagatct cagtgtaggt taaagataca aacctgggcc agggagacag
     6901 tgtagcgggt aaaaagcaat ttccacacaa agagaggaga gaaccaactc acaggagttg
     6961 tcccctgatc tctgcatgca cacgcatatg cagtgtatat cccctgtcat atacattcac
     7021 acaataagta aattcttaaa aagattaaat gatgtcatca gagttatggc ctaatcaatc
     7081 ccatggggct ggtaaaagga aaaaaaatcc tgggttagct gactgaaaat acatatttta
     7141 attaccttta taatttaaaa acaattgaca gaactgttga cagactgttg aaaacattaa
     7201 aggaaattat ttaatccttt aa
//
LOCUS       NM_001438236            5605 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus defective in cullin neddylation 1 domain
            containing 3 (Dcun1d3), transcript variant 1, mRNA.
ACCESSION   NM_001438236 XM_008759750
VERSION     NM_001438236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5605)
  AUTHORS   Ma,T., Shi,T., Huang,J., Wu,L., Hu,F., He,P., Deng,W., Gao,P.,
            Zhang,Y., Song,Q., Ma,D. and Qiu,X.
  TITLE     DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle
            progression and cell growth
  JOURNAL   Cancer Sci 99 (11), 2128-2135 (2008)
   PUBMED   18823379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_008759750.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.4202.1,
                                           SRR26643298.4964.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676807 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000001.1  183716270-183716424 c
            156-692             JAXUCZ010000001.1  183681017-183681553 c
            693-5605            JAXUCZ010000001.1  183674364-183679276 c
FEATURES             Location/Qualifiers
     source          1..5605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..5605
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="defective in cullin neddylation 1 domain containing
                     3"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
     exon            1..155
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     exon            156..692
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    175..177
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="upstream in-frame stop codon"
     CDS             262..1176
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /EC_number="3.1.-.-"
                     /note="DCUN1 domain-containing protein 3; defective in
                     cullin neddylation protein 1-like protein 3; DCN1,
                     defective in cullin neddylation 1, domain containing 3"
                     /codon_start=1
                     /product="DCN1-like protein 3"
                     /protein_id="NP_001425165.1"
                     /db_xref="GeneID:309035"
                     /db_xref="RGD:1308893"
                     /translation="MGQCVTKCKNPSSTLGSKNGDRDPSSKSHSRRGASHREEQVPPC
                     GKPAGDILVNGTKKAEAATEACQLPTSSGDAGRESKTNAEESSLQRLEELFRRYKDER
                     EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
                     GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNP
                     PVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEW
                     EMERRKREVEGRGALSSGPEGLCPEEQT"
     misc_feature    262..522
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    751..1089
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    751..1089
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="Cullin binding; Region: Cullin_binding; pfam03556"
                     /db_xref="CDD:460971"
     misc_feature    1114..1173
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V8B2.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            693..5605
                     /gene="Dcun1d3"
                     /gene_synonym="DCNL3; RGD1308893"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgaggag gaggcggcgg ccgcggtggc agaaaaggcg gcggcggcgg gggtagggag
       61 cctggaaacg caagcgggga tggtaggtag tttggacccg ccgggccgcc gtcgtttcca
      121 gaaagggttt gactggagga acctctggag cagctgttgg ctggctcctc taactgatgg
      181 catgttgaag tacatggacc agtggcagcg aagggatctg atccagagtg ggccactcta
      241 gaaggccagg ctacaatcac catgggccag tgtgtcacca aatgcaagaa tccttcatca
      301 accttgggca gcaagaatgg agaccgggac cccagcagca agtcacacag caggcggggg
      361 gctagccacc gtgaggaaca ggtgccacct tgtggcaaac cagctgggga tattcttgtc
      421 aatgggacca agaaagcaga ggctgccacc gaggcctgcc agctgccaac ttcttctgga
      481 gatgcaggga gggagtccaa gaccaatgct gaggagtctt ccttgcagag gttggaagaa
      541 ctgttcaggc gctataagga tgagcgggag gatgcaattt tggaggaagg catggagcgc
      601 ttttgcaatg acctatgtgt tgatcctacg gagtttcgag tgctgctctt ggcctggaag
      661 ttccaggctg ctaccatgtg caaattcacc aggaaggagt tttttgacgg ctgtaaagca
      721 ataagtgcag acagcattga tgggatctgt gcacgtttcc ctagcctctt aacagaagcc
      781 aaacaagaag ataaattcaa ggatctctac cggtttacat ttcagtttgg cctggactct
      841 gaagaagggc agcggtcact gcatcgtgaa atagccattg ccctgtggaa attagtattt
      901 acacagaaca atcctccagt attggaccag tggctaaatt tcctaacaga gaacccttcg
      961 ggaatcaagg gcatctcccg ggacacttgg aacatgtttc ttaacttcac tcaggtgatt
     1021 ggccccgacc tcagcaacta cagtgaagat gaggcctggc cgagtctctt tgataccttt
     1081 gtggagtggg aaatggagag aaggaaaaga gaagtggaag ggagaggtgc actcagctca
     1141 gggcccgagg gcttgtgtcc agaagagcag acttagctgc tctgttccag gagcagcact
     1201 gaggatctgc ctgctgccct gcagccaagt gaggaattgg acctttctgg aaattaccga
     1261 agatccggat attttctact ttcacctttc tctgccttgt atttgaaagg gctctaaaat
     1321 gctgtatcat gttttaggca ctttcttcat tttttttttt gggttatttt ggttatttct
     1381 ttttgggggt gggaaatccc cccaaaatat ttgaacctgg ctacatgttg tgtacctttt
     1441 tttgaagcct tcagatagaa taagcctgcc atttcttgca caactttatt agatttgttt
     1501 tgtttttgtg ggggagggtg tagacccggg ttggggagtg ggactgttag gttgaattaa
     1561 cattacaaaa tgatacagtg ccagatctca gttttgcata ttatttttca gggcaggtct
     1621 gtactgtgtg tagtgctgtt tacatggttg aatttaggtt gtaataatta ttttaaaaga
     1681 tttacacaga tatgaatata gcagtgttaa ctgttagcca cattgcatta atttccagac
     1741 agtttggagc tcttggagag ccaaggccaa ggcccgtcag gagcatttgc agtcttgaca
     1801 ccccacccca tccctttacg ctaatttatc caaagcccta tctccctcac ttcctgctca
     1861 ttccttctct aacctatatt gcatttcatg tttaacttat ccatcaacat gctgtacctg
     1921 tcagtcaagt gagcagtttt gttttgttcg aacacattgt actgaaaacc acttaagcat
     1981 tgaatgcaga gaaagcagtg ctacctcagt tttgctggaa gtagacttct ttgatatttt
     2041 ctttgatgtt tttgtatttt catgtcataa gtggaaatac ttctttttcc cccttttcat
     2101 ttgccttgga gccaaagttt ccgttgttgt gggtggtgag aaaagtgtgc ctgcctgcct
     2161 gcctgccagc tgaccggaca gaaagctgtg gcatggggct ctgctccaga ctgcttttct
     2221 ttagtttttg ttgagtatca ctagcttact tgtctggcaa gtgcagaagc ctgaggctgg
     2281 cctgaactct gccaaacaaa ttatccacgt gtattgaatc attaaatgtg tgccctctcc
     2341 ctctttgctg cgcccatgtt gtcacttaac cccaggagtt atttattgtc ttttgttagt
     2401 gtcaggctca cctggggtga cgtgatggct gtttaggttt acacggccct ctgctctttc
     2461 cctactccca gacatgtata tatacatata taagatatgt atatatttta ccttataaaa
     2521 tatatatata cacatatatg tatctatatc cctgcgtttg tctgctaaaa ctggccatga
     2581 aagagggagc tgccttcaat ctgtagttta agaagatgcc agggagcatc ataaatggag
     2641 gctgttgtat attaatttag atttttttca ctaaaaagaa catgaatgaa tttgctcgca
     2701 ggaaggagga accagttctc tagaccccat gctcactcta caagaccagc tttggtcaag
     2761 ctgcccctgg ggcctgaaga gctgactatc tcctgcctgt tccattagag gaccatcttg
     2821 ataatttccc cttaaaaata tcctcaaaaa tgtactggaa ggtgggtggc aggagcttgt
     2881 acagttcagc ttccaacatt tcggaacaga tttaaaaggg aatcttttaa taaataaaag
     2941 ctacaaaaat atttatactc ttgatacaat gaaaaagtgt ctattaaata tttggaattt
     3001 tcttccttga ttagtctgcc ccaaatcctg ggtatgtttc tcaacctggg taagaattgc
     3061 atgctttgag ttcttcatga gtcttatagc tctgggcact tatctctata aagatgatta
     3121 ttttaggaga tgacagtcat atttcctgaa gttggtattg acacagggaa catttttgta
     3181 agcctcacaa ttgtcctttc ttgagggatg agatgatgaa aatcagccac agacttaaga
     3241 tagtgctgga aggcacaagt ggctattggg ccagatgtac ccctttcttc tagctgaaat
     3301 aagagacatc cttgagttag aatctaggag cccagcagtt tctgagggca cagctacata
     3361 cctttggata aaagctcacc aaaccagtta gttgttccta attcaggatt agaagaagtc
     3421 caatgaggga aaaagcggag ttaggtaagt aagactttct gtcccagata agaaagggtg
     3481 ggtgtatggc ggggaagtgc caagagaggg agtctgccaa gggccccatg gactcaagga
     3541 actagattcc ttcccaactg ggtagatttt tttttaactg cccagtttct ccaaccccaa
     3601 tgcctgcacc ccaaccccca gccatttaga aattgtgatt atatttttaa tcatctgttg
     3661 ctgagaaagc agagaaagga acagtcaggg agggactctg ggttctctgt gcagtagttt
     3721 tgttttactg agagactctc agtgaggtgt acagtttgta gttaacactt ctgggataca
     3781 gaaaagcctc tgttcactca gcctcagaca ggcttgctga gaactgggtg gatgagcagt
     3841 ggctgggagc caaattgccc ctcaggtaag ctagctttgt gacttgggtg atgggtgatg
     3901 tggggaggtg cgatatgtgg gtgccatttt gaaattctgc aatgtttaag cattactaca
     3961 cagaatatgt tgaaaattgc ttactttggg caagtgactt tttgagtttc tatggtattt
     4021 ctttagtaac ttattagcaa gctggtatga gataaaaagt tactttactg aattctttcc
     4081 cctagtcttc cttgccatac ttgaatgtat cattcttaat gacactttgc tgtacttctg
     4141 ggggttgcct cagcaactct ctcttcactg gcagatgtgc caacatgtat gttgggtcca
     4201 gaagtctgta tgtacccatc ttataaagaa gtctccagag ctggctgaaa ttccaaattt
     4261 cagccaaagc tttgggccaa gggaaagata gtagaaaatg tgcaaagcag tactgttcat
     4321 gttagatgga tggatacagt gaagaattaa gcctcacaca gaattagctt gaaacagtac
     4381 tgtcacctag ggtctggtct ctaggctaga tcaggttatg ggaccctata aattatgtaa
     4441 ttagactata cattggtggg aagttgctaa gataaagact tgctcaaaag actaacagca
     4501 aaagatgtgt gtattgaaat gtatagtttg ctgtagttca agtggagtct tcagtgcagc
     4561 aggtagacct agttatacag ttatgtatgg aatggaaagc aaactactgt taaacggttt
     4621 ttgtctctcc cctgccacct tctttagatt tcttaatctc ctgtgtgtgt caggatggct
     4681 agtgatgacc tgaacatcta taactgacaa aggtctactt gggggactaa agcagtattt
     4741 agcttaaata tgtgaaagaa caaaattatc aaaagatgtt gattaggatt atttaaggtc
     4801 atgtgacatt gatcttttct tctacgtcat ggttcttgcc acactcctat tctgagttta
     4861 tttttttggt aagctgtagt tgtagcccat aacagtttga cctggcctag gactacatgc
     4921 tggggatgct catcaggacc tccccccccc cccttttttt tttttcaaag aaggatgctt
     4981 gagcattggg cacagatgct gaggtggttt gactagctga agttctgatt cgggtgttgg
     5041 ggcatcatat tctgtttctc ttgggaaccc agcctgctct catagatacc tacttctatc
     5101 acataccctg agcattgcca aaagaagcca ttcagcagct gctgtttttc tctcagcaca
     5161 aatatatttg ctacagaaga actatctttt ctctaatact aattccccgt ccagtcctca
     5221 gaatctgatt aactgttctt ccctgctgca ctgaatatgt tcgagatttt aaagagggaa
     5281 tttgaagcaa taggcaaaca gggcttggtt gaattggtct tgcatatatc ctgtcttaag
     5341 ccaatgaggt gatgagtcca ctgctcatgt gaccctgcac ctttgtggat ccttcttggt
     5401 ttgtgaccag tgtacgtttc ttgaggttgt acaaacttga caaaagttaa tacttttgta
     5461 ttctctgcac tgttgcactc ttcaaatagc cccctgaata ttaccttgat atacacattt
     5521 ttgtctttga tgtctacagt atttttcttt tttttttaaa tttgaaggtt atctgctgtt
     5581 ggattcaata aatttgttta cctaa
//
LOCUS       NM_001017471            2015 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus activating transcription factor 7 interacting
            protein 2 (Atf7ip2), transcript variant 2, mRNA.
ACCESSION   NM_001017471 XM_573040
VERSION     NM_001017471.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083663.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573040.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2015
                     /gene="Atf7ip2"
                     /note="activating transcription factor 7 interacting
                     protein 2"
                     /db_xref="GeneID:497859"
                     /db_xref="RGD:1583744"
     exon            1..67
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..222
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    72..74
                     /gene="Atf7ip2"
                     /note="upstream in-frame stop codon"
     CDS             78..1259
                     /gene="Atf7ip2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="activating transcription factor 7-interacting
                     protein 2 isoform 2"
                     /protein_id="NP_001017471.1"
                     /db_xref="GeneID:497859"
                     /db_xref="RGD:1583744"
                     /translation="MESPDRKRRKVLKAKKTMPTSCRKQMEILNQSKNVEAPKTTVVT
                     NIPNGHNQKMFSENKENVKVMKTSEQINENACEALERHTALLEQVKHWIRQEICTINC
                     NLFDKKLNELNERIGKTQCRSKHEAIAGELFIKIRRLQKRIKTVLSSQGNCLEPNTLP
                     SNTVCKVTDSVNLSVTQRSVKSQSKRMSSVNHTPFNSSEKASRKINLPSACVEFVSES
                     NDDVMLISVENPNLTTPIASDPTEIRKNTSRNVSSSPNARSEVVPVEKKFDFVIDLTR
                     EGLSSYSIGPPSSRLHHLRIAPSAEDQAFNTGAFGDHSNSRVQQIGTKPSTRRKKIPV
                     KEKENLQQENTTRRGDGGGYSRVQKSELTGTRPPGMSSSSSDNRKGFNTSFLNQNRTL
                     P"
     misc_feature    252..878
                     /gene="Atf7ip2"
                     /note="ATF-interacting protein binding domain; Region:
                     ATF7IP_BD; pfam16788"
                     /db_xref="CDD:465271"
     misc_feature    252..878
                     /gene="Atf7ip2"
                     /note="ATF-interacting protein binding domain; Region:
                     ATF7IP_BD; pfam16788"
                     /db_xref="CDD:465271"
     exon            223..341
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..476
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..575
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..730
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..801
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..863
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..930
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1083
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1985
                     /gene="Atf7ip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgggggtc attttgtctg gggtctcagc tctcgctgag ggcttctgag gaccggcggc
       61 gctctaggat atgaaatatg gaaagtccag acagaaaaag acggaaggtt ttaaaggcca
      121 agaagacaat gcctacaagt tgccggaagc agatggagat cctgaaccag tcaaagaatg
      181 ttgaagctcc aaaaacaaca gttgtgacta atattccaaa tggccataat cagaagatgt
      241 tttcagaaaa caaagaaaat gttaaggtca tgaaaacttc agagcaaatt aatgaaaatg
      301 cttgtgaggc tctggaaagg catacagcac tgctagaaca ggttaaacat tggattcgac
      361 aggaaatctg cacgataaac tgtaatttat ttgataaaaa actgaatgaa ttgaatgaac
      421 gcattgggaa gacccagtgc agaagtaagc atgaagcaat agctggtgaa ctctttataa
      481 aaataagaag acttcaaaaa cgtatcaaaa ccgtattatc atctcaagga aattgtttgg
      541 aaccaaacac attacccagt aacacagttt gtaaggttac agattctgtg aatttgagtg
      601 tgacccaaag gtcagttaaa agtcaaagta aaagaatgtc ttctgtgaac catacgcctt
      661 ttaactcttc agaaaaagca agtagaaaga ttaatttgcc atcagcttgt gttgagtttg
      721 tttctgaaag taacgatgat gttatgttga tttctgtgga aaatcctaat ttgacaactc
      781 caattgcatc agatccaaca gaaattagaa aaaatacatc aagaaatgtc agcagttctc
      841 ctaatgccag gagtgaagtt gtgcctgtag agaagaaatt tgactttgtt attgacctga
      901 caagagaagg cctgtccagc tacagcatag gccctccttc atcaagatta caccatctcc
      961 gaatagcacc atcagctgag gaccaagcct tcaacacagg ggcctttggg gaccattcca
     1021 attccagagt gcaacagata gggaccaagc cctccaccag gagaaagaag attcctgtga
     1081 aagaaaaaga aaatcttcag caagagaaca ccactagaag aggagatgga ggaggctaca
     1141 gcagggtaca gaagtcagag cttacaggaa cccgacctcc aggaatgagt tcctccagca
     1201 gtgacaacag gaaaggtttc aacacctcct ttctgaatca gaaccggacc ttaccttgac
     1261 caaggctgct taactacgtt atgtccatgt caaagccttt aaaagaagag cacttagtga
     1321 ttaaacctgc tccagtgact ctaggacagt gaagtcctgt acagctatga ctggaactgg
     1381 gtagagttaa tactatacag aagctggaga ggtagcggca ttcttgttgg gtgtgtgcaa
     1441 agcagtcagt gggcgctctt tctgtgatca ccgtttgaga cagtgcctgg tgtgctcagg
     1501 ttagtcttaa cccactgtgg actcaagata accagcacac gttttgatgt ttctggggtc
     1561 cgtgtaacca ttctgatgga ccccaccacc atcagccagc ctgatagctc ggctcgctct
     1621 cccctggctg ccatctgtct gttggcattg actcattgcg tgtctcgtgg gtagctaagg
     1681 aacacttgac atcaagaacc aaatctggat agcttgtgct gttccttgcg cttggagatt
     1741 tgaacattaa catgtccttg acaaattatg tcttccctta acctgaaaca agaatgtaaa
     1801 tgggtggctg ggaagaaaat gaggacaact gggagagcta gcataaagct gtcaatcaac
     1861 cattttcttc aagtgtcaaa tgcagtggaa agaactgttt atctgcaaga ctagccatga
     1921 cagtcttaag tcttcgtcat ctgaagtttt gatccttgtt ttacaattaa attcatgaaa
     1981 aattgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
LOCUS       NM_001438214            2134 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 668 (Zfp668), transcript
            variant 1, mRNA.
ACCESSION   NM_001438214 XM_017589218
VERSION     NM_001438214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Kim,S., Elkon,K.B. and Ma,X.
  TITLE     Transcriptional suppression of interleukin-12 gene expression
            following phagocytosis of apoptotic cells
  JOURNAL   Immunity 21 (5), 643-653 (2004)
   PUBMED   15539151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_017589218.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.5514.1,
                                           SRR26643296.2909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000001.1  191915312-191915404 c
            94-762              JAXUCZ010000001.1  191907790-191908458 c
            763-2134            JAXUCZ010000001.1  191906065-191907436 c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2134
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
     exon            1..93
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     exon            94..762
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1975
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform 1"
                     /protein_id="NP_001425143.1"
                     /db_xref="GeneID:309002"
                     /db_xref="RGD:1308623"
                     /translation="MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATH
                     TTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQR
                     GHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPF
                     HCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGA
                     GIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEE
                     TDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA"
     misc_feature    185..247
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    185..247
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    308..1372
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    308..1372
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    371..433
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    371..433
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    455..517
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    455..517
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    539..601
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    539..601
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    623..685
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    623..685
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    707..769
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    707..769
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    791..853
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    791..853
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(806..808,812..814,818..820,824..829,836..841,
                     848..850,890..892,896..898,908..913,920..925,932..934,
                     974..976,980..982,986..988,992..997,1004..1009,1016..1018)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(806..808,812..814,818..820,824..829,836..841,
                     848..850,890..892,896..898,908..913,920..925,932..934,
                     974..976,980..982,986..988,992..997,1004..1009,1016..1018)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    857..1909
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    857..1909
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    875..937
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    875..937
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    959..1021
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    959..1021
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1043..1105
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1043..1105
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1127..1189
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1127..1189
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1211..1273
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1211..1273
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1295..1357
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1295..1357
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1667..1729
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1667..1729
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1682..1684,1688..1690,1694..1696,1700..1705,
                     1712..1717,1724..1726,1766..1768,1772..1774,1784..1789,
                     1796..1801,1808..1810,1850..1852,1856..1858,1862..1864,
                     1868..1873,1880..1885,1892..1894)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1682..1684,1688..1690,1694..1696,1700..1705,
                     1712..1717,1724..1726,1766..1768,1772..1774,1784..1789,
                     1796..1801,1808..1810,1850..1852,1856..1858,1862..1864,
                     1868..1873,1880..1885,1892..1894)
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1751..1813
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1751..1813
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1835..1897
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1835..1897
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            763..2134
                     /gene="Zfp668"
                     /gene_synonym="RGD1308623; Znf668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcctagc gcctgcctct ctccgagtgt ccagagctct gtcagcgcta ggcaccaccg
       61 ccgaagctgc ggagcctgcg aaaatcgaac cagagaaggt ctactcaccg aggccatgga
      121 agtggaggct gcagaggcca agtccccagg cccctgctac aagcgctctg gccgccgtta
      181 taagtgcctg ttttgtacaa agacatttcc aaatgctccc agggcagccc gccatgctgc
      241 tacacataca actacagact gcacagagga ggtgaatgag gtccagccga aggtggatgc
      301 agagcccaag gctgaggaag ccagtggaga caaggtatct gggtcagtag ccaagccccg
      361 gccctatgct tgccctctgt gccccaaggc ctacaagaca gctcctgagc tacgcagcca
      421 tggacgcagc cacactggtg agaagccctt cccgtgccca gagtgcggcc gccgtttcat
      481 gcagccagtg tgcctgcgtg tgcacctggc ctcacacgct ggtgagctgc ctttccgatg
      541 cacacactgc cccaaggctt atggtacact ctctaaacta aagatccacc agcgtgggca
      601 cacaggcgag cggccctatg cctgtactga ctgcggcaag agctttgctg atccttcagt
      661 gttccgcaag catcggcgca cgcatgcagg cctgcgcccc tacagctgcg agcgctgcgg
      721 caaggcctat gctgagctga aggacttacg caaccacgaa aggtcccaca cgggtgagcg
      781 ccccttcctc tgctcagagt gtggtaaaag cttctctcga tcctcttccc tcacatgcca
      841 tcagcgtatc catgcagccc agaaacccta tcgctgcccg gcttgtggta agggcttcac
      901 acagctcagc tcttaccaaa gccatgagcg cacacattca ggcgaaaagc ccttcctgtg
      961 ccctcggtgt ggccgcatgt tctctgatcc ctcgagcttc cgccgccacc agcgggcaca
     1021 tgagggtgta aagccttacc gctgtgagaa atgtggcaag gacttccggc agccagctga
     1081 cctggccatg caccgtcgag tacacaccgg cgaccgaccc ttcaagtgcc tgcagtgtga
     1141 caagactttt gtggcttcct gggacctcaa gcggcatgca ttggtacact caggacagcg
     1201 gccgttccgc tgtgaggagt gtgggcgagc atttgctgag cgagctagcc ttacaaagca
     1261 cagccgcatg cactctggcg agcgtccttt ccactgtaat gcctgcggga aatcctttgt
     1321 ggtgttatcc agcctcagga agcatgagcg cacccataga agcaacgaga ctacgggagc
     1381 tgccccccag caggagttgg tactgggact agcactgcct gtaggtgtcg taggtgaggg
     1441 ctcagctgcc cctgtggcag gtgcagggat aggggatgct ccagcagggc tgctagggtt
     1501 accgcctgag tctggtagtg tagtggccac acagtggcaa gtggtgggca tgactgtaga
     1561 gcatgtggag tgccaggatg ctggcgttgg cgaagctcct agtaccctgg gagatgcagg
     1621 agaggtgggt ggggaggaga ctgatgagaa gcccccacag tttgtgtgtc gagagtgcaa
     1681 agaaactttc tccacactga cattgctacg caggcatgaa cgctcacacc cagagctccg
     1741 gccctttccc tgcacccagt gtggtaagag cttctcagac agggctgggc ttcgtaagca
     1801 tagccgcacc cacagctctg tacgccccta ctcctgttcc caatgtccta aagctttcct
     1861 gagtgccagt gatctgcgca aacatgaacg cacccaccct gtgcccatcg ggacccccat
     1921 acccctggaa ccccttgtgg ctctgctagg aatgccagaa gaagggtcag cctgaagttt
     1981 atagatctcc actacactcc cagaaggcca tccctagtct ccaaacccct gcctctgggc
     2041 agctagctca gttctcgtcc actaagagct gtggacagtg gaagctggta gcatttgtga
     2101 gaggtactca ttaaagcatt ggctttgata ccaa
//
LOCUS       NM_001438192            2487 bp    mRNA    linear   ROD 18-APR-2025
DEFINITION  Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku),
            transcript variant 2, mRNA.
ACCESSION   NM_001438192 XM_006229759
VERSION     NM_001438192.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Ohta,K., Ito,A., Kuriyama,S., Lupo,G., Kosaka,M., Ohnuma,S.,
            Nakagawa,S. and Tanaka,H.
  TITLE     Tsukushi functions as a Wnt signaling inhibitor by competing with
            Wnt2b for binding to transmembrane protein Frizzled4
  JOURNAL   Proc Natl Acad Sci U S A 108 (36), 14962-14967 (2011)
   PUBMED   21856951
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Ito,A., Shinmyo,Y., Abe,T., Oshima,N., Tanaka,H. and Ohta,K.
  TITLE     Tsukushi is required for anterior commissure formation in mouse
            brain
  JOURNAL   Biochem Biophys Res Commun 402 (4), 813-818 (2010)
   PUBMED   21055390
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Coffy,S., Decaux,J.F., Girard,J., de Keyzer,Y. and Asfari,M.
  TITLE     Identification of a novel rat hepatic gene induced early by
            insulin, independently of glucose
  JOURNAL   Biochem J 385 (Pt 1), 165-171 (2005)
   PUBMED   15344907
  REMARK    GeneRIF: Tissue distribution of EIIH in adult rats revealed a
            pattern of expression mainly in the liver, intestine and islets of
            Langerhans, closely following that of the Glut2 (glucose
            transporter 2), suggesting that it may play a role in carbohydrate
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006229759.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY533242.1, SRR26643287.1664.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000001.1  162082718-162082764 c
            48-2487             JAXUCZ010000001.1  162071459-162073898 c
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2487
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="tsukushi, small leucine rich proteoglycan"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
     exon            1..47
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     exon            48..2487
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1117
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat-containing protein 54; early
                     insulin-induced hepatic gene protein; hepatic protein
                     EIIH; tsukushin"
                     /codon_start=1
                     /product="tsukushi precursor"
                     /protein_id="NP_001425121.1"
                     /db_xref="GeneID:308843"
                     /db_xref="RGD:1359311"
                     /translation="MLCTLFLLLLALGTVQTTRPCFPGCQCEEETFGLFDSFSLIRVD
                     CSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITP
                     TAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRA
                     LHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPNLRDLPLRYLSLDGNPL
                     ATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVF
                     SGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSP
                     KVVLHCGDTQESARGPDIL"
     sig_peptide     56..106
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     107..1114
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /product="Tsukushi. /id=PRO_0000240409"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1)"
     misc_feature    233..295
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 1"
     misc_feature    242..313
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    242..313
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    278..280
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    <308..>973
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    <308..>973
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     Region: LRR; COG4886"
                     /db_xref="CDD:443914"
     misc_feature    311..376
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 2"
     misc_feature    323..385
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    323..385
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    383..448
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 3"
     misc_feature    386..454
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    386..454
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    452..517
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 4"
     misc_feature    455..532
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    455..532
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    467..469
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    533..613
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    533..613
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    533..595
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 5"
     misc_feature    611..676
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 6"
     misc_feature    614..670
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    614..670
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    626..628
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QMY6.1); glycosylation site"
     misc_feature    677..748
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    677..748
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    677..739
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 7"
     misc_feature    746..814
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 8"
     misc_feature    749..823
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    749..823
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    821..886
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 9"
     misc_feature    824..898
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    824..898
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    896..961
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QMY6.1);
                     Region: LRR 10"
     misc_feature    899..970
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    899..970
                     /gene="Tsku"
                     /gene_synonym="Eiih"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      
        1 gggtcgccta ggtgagcgtg ccgaggcgac agctgccgac ctgccaggtg tcaccatgtt
       61 gtgcaccctg ttcctgctac tgctggccct gggcacagtg cagacaactc ggccatgttt
      121 ccctggctgc cagtgtgagg aagagacgtt tggcctcttt gacagtttca gcctgatccg
      181 agtggactgc agcagcctgg gcccccacat tgtgcctgtg cccatccctc tggacacagc
      241 ccacctggac ctgtcttcca accggctaga aaccgtgaat gagtcagtcc tgggagggcc
      301 aggctatacc acactggctg gcctggatct cagtcacaac ctcctcacca gcatcacgcc
      361 cactgccttc tcccgccttc gctacctgga gtcactggac ctcagtcaca atggcctggc
      421 agccctgcca gcagaggttt tcaccagctc ccccttgagt gatatcaacc tgagccataa
      481 tcgacttaga gaggtctcaa tatctgcctt caccacccac agccaggggc gggcactgca
      541 cgtggaccta tcccacaatc ttatccaccg cctgctcccc tatccagcca gggccagcct
      601 gtccgcacct accattcaga gcctgaacct gtcctggaac cggctccgag ccgtgcccaa
      661 tctccgagac ctacccctgc gttacctgag cctggatggg aaccctctgg ctaccatcaa
      721 cccaggcgcc ttcatggggc tggcgggcct cacccacctt tcactggcaa gcctacaggg
      781 tatcctccag ctaccacccc atggcttccg agagctccca ggccttcagg tcctggactt
      841 gtctggtaac cccaagctca agtgggcagg agccgaggta ttttcaggcc tgggtttgct
      901 gcaagaacta gacctgtctg gctccagcct ggtgcccctg cctgagacgc tgctacatca
      961 cctccctgct ttacagagtg tcagtgtagg ccaagatgtg cagtgccggc gtctggtacg
     1021 ggagggtgcc taccaccgcc aacccggttc cagccctaag gtagtcctgc actgtggaga
     1081 cacccaggaa tctgccaggg gcccagacat cttgtgacga atggtgtggc ctgaggccac
     1141 ttgacagact gctgtcctgg gcttgctcag gtccccacta atattttaat gtgccaatgc
     1201 ctgtggagtg tctacaggtc taagtggcag ccatctcagt gaagatgtgg gccaaggata
     1261 gttttcatac ctagggccta tacccaataa cagaatctgc ccgcttgtct cagcggctca
     1321 cttccctgag ctatgagcaa agggacttcg atgccaaacc agactttggt cccttcctga
     1381 gccctgcccc agttatctct aagtgccttc ccttttgccc agactgacct gacccatgat
     1441 gtaaggaccg taggggagca ccaccactgc aaaggctgac taaggtctgt tgggctaaag
     1501 gtctctttga gcccagtgtc tatagtcaca ccttctttgc tctgggccca ggaggcctac
     1561 ttcttctttt tctcgtggaa tcctggaatc ttaaagataa aagaacctag aaagaaaatc
     1621 aaacccattt tccttgtggg gcagatggta atatgggact gagaacagca aacctggggt
     1681 cttggagagg agcccagcct cctgttgagg ttgagagctc tgtcaccctc ccttcccctg
     1741 ctgggtaccc tgttactatt gtctgtactg ttttccattg tgcccagcag tagcaacaac
     1801 aaggtcacag aggtgggaac tctaggtcca gtggccagct tatggtgtga gcgtagtcag
     1861 tccccctttc agagcctcag gaagcttgga gcacctcagt ctcaagcctg tcagttcctt
     1921 actctgggat gacccccaac atcaagactg gaaacataca cattctcccc agggacacag
     1981 tcttaagatg cttttctaag aagtcaatgc agttgtgacc atgtggccat gagctccaag
     2041 ggactcgtgg gcttggtgtc catgggccgg agcccaaaga cccgcttccc cctccaagag
     2101 tatggcagaa agggtctccc atgcacattg tgctccccgc cagggccaca tctcagctct
     2161 ccagctctgg attctttctt ctgttttcat tttatgagtc gttgtctttt ttaaaatgaa
     2221 ctgtttaacc cccacctctg ctggccaggg gatggaaagg aagataaatg tatttgttcg
     2281 cttttgtaag actctgttct gggtgtgggc tggggatctt gggaagaagc cagttggcta
     2341 tcagtaacca tgtgggcatt ggggctggtc cctgggatgc tcaaaagtca gtgagagctc
     2401 tgtcttctca cactagccca gcccagccca ccccgtgact ggtccttggt ttaataaaca
     2461 catgtaagag ctctttccat cactgga
//
LOCUS       NM_001107527            4200 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus mannosidase, alpha, class 2A, member 2 (Man2a2),
            transcript variant 4, mRNA.
ACCESSION   NM_001107527 XM_001066272 XM_218816
VERSION     NM_001107527.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Akama,T.O., Nakagawa,H., Wong,N.K., Sutton-Smith,M., Dell,A.,
            Morris,H.R., Nakayama,J., Nishimura,S., Pai,A., Moremen,K.W.,
            Marth,J.D. and Fukuda,M.N.
  TITLE     Essential and mutually compensatory roles of {alpha}-mannosidase II
            and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 8983-8988 (2006)
   PUBMED   16754854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218816.4, XM_001066272.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..4200
                     /gene="Man2a2"
                     /note="mannosidase, alpha, class 2A, member 2"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
     exon            1..84
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..286
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    186..188
                     /gene="Man2a2"
                     /note="upstream in-frame stop codon"
     exon            287..437
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..3800
                     /gene="Man2a2"
                     /EC_number="3.2.1.114"
                     /note="isoform 4 is encoded by transcript variant 4;
                     alpha-mannosidase 2x; mannosidase 2, alpha 2"
                     /codon_start=1
                     /product="alpha-mannosidase 2x isoform 4"
                     /protein_id="NP_001100997.1"
                     /db_xref="GeneID:308757"
                     /db_xref="RGD:1310238"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPARHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPALLPYHTANGSWAVLP
                     EPRPSFFSVSPEDCQFALGGRGQKPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPND
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLER
                     NLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVADRAALLLDQYRKKSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN
                     SKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLETHLRGAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQ
                     MDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQP
                     LSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNG
                     VKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVRRVDEEQEQQVDMK
                     LFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEVAAYYEHFHQVIR
                     LYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQVQPRKYLK
                     KLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGL
                     GQGLKDNKITCNHFRLLLERRTLMSPEVQQERSTSYPSLLSHMTSMYLNTPPLVLPVA
                     KRESTSPTLHSFHPLASPLPCDFHLLNLRMLPAEVSVPVRANPHHQAEDTLPAADAAL
                     ILHRKGFDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVLFLQPTSLTLLYPLASPSNS
                     TDISLEPMEISTFRLRLG"
     misc_feature    723..3794
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     misc_feature    723..3794
                     /gene="Man2a2"
                     /note="alpha-mannosidase; Region: PLN02701"
                     /db_xref="CDD:178304"
     exon            438..695
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..840
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1012
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1140
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1314
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1501
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1679
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1882
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2065
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2180
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2248
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2414
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2651
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2774
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2889
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3023
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3165
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3302
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3539
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3647
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..4200
                     /gene="Man2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctggcg gaggtccccg gggatgcgag cagtggcggc ttggcgggcc gggtccggag
       61 cgccgcggag gccggccgcg tacgctccgc cctctgtggc ccggacccaa tctccaggga
      121 ctaaaaatat tgcccggagg ctcctgagcg gaatcagatc gcgttaagta ggacgcaggc
      181 tgaggtgaca gagcttttca gcaccagggc cggaagagca gactccagaa cgcggtcccg
      241 cccacgcgcg ttcaggagct agcgtcctcc ctcctccagc aggcaagagt gtgcctggtg
      301 tcagtatgaa gctgaaaaag caggtgacag tgtgcggggc tgctatcttc tgtgtggccg
      361 tcttttccct gtacctaatg ctggaccgag tgcagcatga tcctgccaga caccagaatg
      421 gtgggaactt ccccaggagc caaatttctg tgctacagaa ccggatcgaa cagctggaac
      481 agctgctgga agaaaaccat gagatcataa gccatatcaa ggactctgtg ctggaactga
      541 cagccaatgc ggagggccca ccagccctgc tgccctacca cacagccaac ggctcctggg
      601 ctgtgctccc cgagccccgg cccagcttct tctctgtatc ccctgaggac tgccagtttg
      661 ctttgggggg ccggggtcag aagccagagc tacagatgtt aactgtgtct gaggatttgc
      721 cgtttgacaa tgtggagggc ggcgtgtgga ggcaaggctt cgacatctcc tacagcccaa
      781 atgactggga tgctgaagac ctgcaggtgt ttgtggtgcc tcactcccac aatgatccag
      841 gctggatcaa gacttttgac aagtactaca cggaacaaac ccaacacatc ctcaacagca
      901 tggtgtccaa gctgcaggaa gatccccgac ggcgctttct ctgggcagaa gtctccttct
      961 tcgccaagtg gtgggacaac atcagtgccc agaaaagggc agcagttcga aggctggtgg
     1021 gaaatgggca gctggaaatt gcaacgggtg gatgggtgat gccagatgag gccaactccc
     1081 attactttgc cctggtcgac cagctcatcg agggacacca gtggctggag agaaacctgg
     1141 gtgcaactcc tcgctcgggc tgggcagtgg acccctttgg acacagctcc accatgcctt
     1201 acctgctgcg ccgtgccaac ctgaccagca tgctaattca gagggtgcat tacgccatca
     1261 agaagcactt tgcggccact cacagcctgg agttcatgtg gaggcagaca tgggattcag
     1321 actccagcac agacatcttc tgccacatga tgcccttcta cagctacgac gtcccacaca
     1381 cctgtggccc tgatcccaag atctgctgcc agtttgattt caaacgtctg ccgggtggga
     1441 gaatcaattg tccttggaag gtgccgccgc gggctatcac agaggccaac gtggcagaca
     1501 gggcagccct gctcctggac cagtaccgga agaagtcccg gctgtttcga agcagtgtcc
     1561 tccttgtgcc gctgggtgat gacttccgat atgacaagcc ccaggaatgg gatgcccagt
     1621 tcttcaacta tcaacggctc tttgacttcc tcaacagcaa gccggagttc cacgtacagg
     1681 cacagtttgg gaccctctct gagtattttg atgccctgta taagaggaca ggagtggagc
     1741 ctggtgcccg gcctccaggg tttcctgtgc tgagtgggga cttcttctcc tatgctgacc
     1801 gggaggacca ctactggaca ggctattaca cttcccggcc tttctataag agcttggacc
     1861 gcgtgctaga aactcacctt cgtggggcag aggttctata cagcctggct ttggcgcatg
     1921 cccgccgttc tggactgact ggccagtatc cgctgtctga ttacgctgtc ctgacggaag
     1981 ctcgtcgtac actgggcctc ttccagcacc acgatgccat caccggaact gccaaggagg
     2041 cagttgtagt agactatggg gtcaggttgc tgcgttccct ggtcagccta aagcaggtca
     2101 tcatcaatgc tgcccactac ctggtgctgg gggacaagga gacctacagc tttgacccta
     2161 gggcaccctt cctccaaatg gatgacagtc gagtaagtca cgatgccctg cctgagcgca
     2221 cggtgatccg tctggactcc tcacccaggt ttgtggtggt ctttaaccca ctggaacagg
     2281 agcggctcag tgtggtgtcc ctgctggtca actcaccccg agtgcgagtg ctttcagagg
     2341 agggtcagcc cttgtctgtg cagatcagtg tgcagtggag ctccgccacc aacatggtcc
     2401 ccgatgtcta ccaggtgtca gtgcctgtcc gcctgccagc cctgggcctg ggtgtgctgc
     2461 agctgcagcc agatctcgat ggaccctaca cactgcagtc ttcggtgcat gtctacctga
     2521 acggcgtgaa actgtctgtc agcaggcaaa caacattccc tctccgtgtt gtggactcgg
     2581 gcaccagtga cttcgccatc agcaatcgat acatgcaggt ctggttctcc ggccttactg
     2641 ggcttctcaa gagcgtccga cgtgtggacg aagagcagga acagcaggtg gacatgaagc
     2701 tcttcgtcta tggaacccgc acatccaagg ataagagtgg tgcctacctc ttcctgcctg
     2761 ataacgaggc taagccctat gtccctaaga aacctcctgt gctgcgtgtc accgaaggcc
     2821 ctttcttctc agaggtggct gcgtattatg agcactttca ccaagtgatt cgactttaca
     2881 acctgccagg ggtagagggg ctgtctctgg acgtgtcgtt ccaggtggac atcagggact
     2941 acgtgaacaa ggagctagcc ctgcgcatcc acacagacat cgacagccag ggcactttct
     3001 tcacagacct caatggcttt caggtacagc cccggaagta tctgaagaag ttgcccctgc
     3061 aggctaattt ctaccctatg ccagtcatgg cctacatcca ggattcccag aggcgcctca
     3121 cgctgcacac tgctcaggct ctgggtgtct ccagcctcgg caatggccag ctggaggtga
     3181 tcttggaccg aaggctaatg caggatgaca accggggact aggccaaggg ctcaaagaca
     3241 acaagatcac ctgcaaccat ttccgcctcc tgttagaacg tcgaaccctg atgagccctg
     3301 aggtccaaca ggagcgctct acaagctacc cgtccctcct cagccacatg acttccatgt
     3361 acctcaacac acctcctctg gtcttaccgg tggccaagag ggagagcacc agccccactc
     3421 tgcactcttt ccaccctctg gcttctccgt tgccctgcga tttccatctg ctcaatctgc
     3481 gcatgctccc cgccgaggtg agtgtcccgg tccgtgccaa tcctcaccat caggctgagg
     3541 acaccttgcc cgcggctgat gctgctctca tcctacaccg caagggtttt gactgtggcc
     3601 ttgaagccaa gaacctgggc ttcaactgta ccacaagcca aggcaagctg gccctgggga
     3661 gcctcttcca tggcctggat gtgctattcc tgcagcccac ctctttgact ttgctatacc
     3721 ctctggcctc gccctccaac agcactgaca tctctctgga gcccatggag atcagcacct
     3781 tccgcctgcg cttgggttag gttagggctt cttgtggcct gaagacgaag ttcatccaca
     3841 aagactgcct cctaacacca agaccgagtt ggaccagcca cactgagtat cacattctgc
     3901 ctcagaactg acagaccatg ctctgccctt acgttgtcta ttgctgcttc tgtgtttggg
     3961 ccagccctta catcagcaga cggcagatac agtgggacag ggagaggagg cccttccctt
     4021 gggttgtaag tagctgccca gctgggcacg gcttaggttc catccttttc ccacaatggg
     4081 atctaggaag agcggggaca aacagaagag gtcagggagg ctgaggggaa caacctcgca
     4141 ccaggtgact ggagttatga ccgtgctctg tggggtgata ggggccccac agtgctggta
//
LOCUS       NM_001427746            2790 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 220 (Rnf220), transcript
            variant 4, mRNA.
ACCESSION   NM_001427746 XM_039111524
VERSION     NM_001427746.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Ma,P., Yang,X., Kong,Q., Li,C., Yang,S., Li,Y. and Mao,B.
  TITLE     The ubiquitin ligase RNF220 enhances canonical Wnt signaling
            through USP7-mediated deubiquitination of beta-catenin
  JOURNAL   Mol Cell Biol 34 (23), 4355-4366 (2014)
   PUBMED   25266658
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 2, 2024 this sequence version replaced XM_039111524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.1502743.1,
                                           SRR21887622.3730119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              JAXUCZ010000005.1  135992371-135993450 c
            1081-1202           JAXUCZ010000005.1  135989870-135989991 c
            1203-1335           JAXUCZ010000005.1  135989404-135989536 c
            1336-1432           JAXUCZ010000005.1  135981970-135982066 c
            1433-1519           JAXUCZ010000005.1  135981716-135981802 c
            1520-1575           JAXUCZ010000005.1  135981554-135981609 c
            1576-1654           JAXUCZ010000005.1  135981364-135981442 c
            1655-1763           JAXUCZ010000005.1  135977575-135977683 c
            1764-1838           JAXUCZ010000005.1  135977386-135977460 c
            1839-2790           JAXUCZ010000005.1  135975739-135976690 c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2790
                     /gene="Rnf220"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
     exon            1..1080
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1044..1046
                     /gene="Rnf220"
                     /note="upstream in-frame stop codon"
     CDS             1047..1910
                     /gene="Rnf220"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 4; E3
                     ubiquitin-protein ligase RNF220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF220 isoform 3"
                     /protein_id="NP_001414675.1"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
                     /translation="MVQLFVLTEVWSRIGKMKRRKQDEGQVCPLCSRPLAGSEQEMSR
                     HVEHCLSKREGSCVAEDDAVDIEHENSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVM
                     CSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGG
                     PPSTRITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEALKA
                     RVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTI
                     TAPGDLRRIYL"
     misc_feature    <1080..1541
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    <1080..1541
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    1743..1898
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     misc_feature    1743..1898
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     exon            1081..1202
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1335
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1432
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1519
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1575
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1654
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1763
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1838
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2790
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggccaaca tggccgccgc cgctgctggg agctgaagtg ccgccgccgc cgggcagccg
       61 gggggaatcc gccggcatcg ccgcccttgc cggccgggct gctacggggc ccagagcgcc
      121 ggaagctggg gctggggcgg caccgcgcgg cggcctcggg ctcccgttag agcagcccgg
      181 gcggctatgc cgagggcccg gagcggccgg cggagcaggg aggccggcgg gagggaggaa
      241 gtaggtttgt ttacgggctg tttggggcgg ggcgggcctg gatgagggtc gggtactagg
      301 gtacggaccg ggactccagg ccgcgtgtga cgctctgttc tctatttttt gcatctgccg
      361 gggattttct cccagacctt cttgcgagtg cgagccaacc ggcaaacccg actgaatggt
      421 gagtccggtc cggcccctcc ctccgcccca cccccggcct cctccctcct ccactgcccg
      481 cagctcctgg cttgcctggg tctcttcatc atcgggccaa ctgacttctt gcagtcacca
      541 cgtctgagag tgcaaaccaa ggctgccgcc ctcagtttcc ccgtctgtct aatggagggt
      601 tacggtactc agctcgtgcc caagtctttc taaaggtccg aaagaaccct gggggacaat
      661 aagtgtcgga gaatgaggaa caagctacac aattccactc gggagctcag ctttgaattt
      721 gcagactgct gggacctcac tatacaagtc ggcagggcgc tgagaatgtt tttcttctag
      781 tttttaatca gtgcccagta gtgtgaatgc agcctctctg ctgagacttg acaatgcaat
      841 gagatctgga gttcccacgg caacagaact aactcgtccc agagctcttt gagttatcag
      901 tcggcccaca tttcacaaag gtgatcagcg tgggctcgac agctcttaga ggccttttct
      961 gaaagcagac cgcgtatgca ctacctggcg gtcccccttt ttggattcaa acctctggag
     1021 cattcctgtt tgctgaacac aattgaatgg tccagctttt tgtgctgact gaggtgtggt
     1081 ctcggattgg gaaaatgaaa cggaggaagc aagatgaagg gcaggtatgt cccctgtgca
     1141 gccgccccct ggcaggatcg gagcaggaga tgagtaggca tgtggagcat tgcctttcta
     1201 agagggaagg ctcctgcgtg gctgaggatg acgccgtgga catcgagcat gagaacagca
     1261 accgctttga ggagtatgag tggtgtgggc agaagcggat acgggccacc acgctcctgg
     1321 aaggtggctt ccgaggctcc ggcttcgtta tgtgcagtgg taaagagaat ccagacagtg
     1381 atgctgacct ggatgtggat ggagatgaca ctctggagta tgggaaacca caatacacag
     1441 aggctgatgt catcccatgc acaggagaag agcctggtga agccaaggag agagaggcac
     1501 tccggggcgc agtcctaaat ggtggccccc cgagcacccg catcacacct gagttctcta
     1561 aatgggccag tgatgagatg ccgtccacca gcaatggtga aagcagcaag caggaagcca
     1621 tgcagaagac ctgcaagaac agtgacattg agaaaatcac cgaagattca gctgtaacta
     1681 cctttgaggc tctaaaggct cgggtcaggg agcttgaacg gcagctatct cggggtgacc
     1741 gatacaaatg cctcatctgc atggactcat actcaatgcc gctgacgtcg atccagtgtt
     1801 ggcatgtgca ctgtgaagag tgttggcttc ggactctggg tgccaagaag ctctgccctc
     1861 agtgcaacac catcacagcc cctggagacc tgcggaggat ctacttatga gctagctgtc
     1921 caggcaggcc ctgcctcgag caaacccctg ctccagcctc tgtgacagtg accgcccctc
     1981 cccccttgta catacttgca cacaggtccc ccgtgtacat acatgcatat acacacccaa
     2041 acacacatag aggactctgg agccagagtg gaacagccct gcctgcttgt tccttctgaa
     2101 cttggggacc atgcctcttt ggactctgtt tccagggttg gcaggaaggt ggtttgggaa
     2161 gtatagcagg acgaggctcc tgagatccat ccccgagact gactgacaga cacgcaaaca
     2221 ccagactgaa gcacatgtaa tatagactgt gtatgtttac aatgttgtgt ataaatggga
     2281 cactttgccc tctaccacct tcccctttgg gtgtatgatt ttcttctttt ataatgactc
     2341 ctggaagcag tgccccttca gggctggctg ggggctcggc ccaaccacct cttagggtgc
     2401 ctgcctcttc ctctcccatg gcatcccttc ccttccccat gtgctcagtg ttcagtggtg
     2461 tatatttctt ctcccaaaca cggggcgtgt gccccgaggg gtctgatcct ctccttagtc
     2521 ttagctcatg gggctcctca tgaggagctg ggggtagggt ggaatgggac caagcaggaa
     2581 caggctgcag gctggctggc tgagggtgcc tggctgccca gcctgctgtt gagaaccacc
     2641 cctggggtag acactgctcc caggggaagt gctggccccg cccctgtgtg ggccctgtgg
     2701 tgtgatgctg tgtctgtata ttctatacaa aggtacttgt cctttccctt tgtaaactac
     2761 atttgacatg gattaaaaca gtataaacca
//
LOCUS       NM_001438327            1068 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus folate receptor beta (Folr2), transcript variant
            1, mRNA.
ACCESSION   NM_001438327 XM_006229858
VERSION     NM_001438327.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1068)
  AUTHORS   Pridans,C., Irvine,K.M., Davis,G.M., Lefevre,L., Bush,S.J. and
            Hume,D.A.
  TITLE     Transcriptomic Analysis of Rat Macrophages
  JOURNAL   Front Immunol 11, 594594 (2021)
   PUBMED   33633725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1068)
  AUTHORS   Lu,Y., Parker,N., Kleindl,P.J., Cross,V.A., Wollak,K., Westrick,E.,
            Stinnette,T.W., Gehrke,M.A., Wang,K., Santhapuram,H.K., You,F.,
            Hahn,S.J., Vaughn,J.F., Klein,P.J., Vlahov,I.R., Low,P.S. and
            Leamon,C.P.
  TITLE     Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate
            of the mTOR Inhibitor Everolimus
  JOURNAL   Mol Med 21 (1), 584-596 (2015)
   PUBMED   26181632
  REMARK    GeneRIF: EC0565 forms micellar aggregates in physiological buffers
            and demonstrates good water solubility as well as strong
            multivalent FR-binding capacity. EC0565 inhibited mTOR signaling in
            rat macrophages at nanomolar concentrations
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1068)
  AUTHORS   Shen,J., Hilgenbrink,A.R., Xia,W., Feng,Y., Dimitrov,D.S.,
            Lockwood,M.B., Amato,R.J. and Low,P.S.
  TITLE     Folate receptor-beta constitutes a marker for human proinflammatory
            monocytes
  JOURNAL   J Leukoc Biol 96 (4), 563-570 (2014)
   PUBMED   25015955
REFERENCE   4  (bases 1 to 1068)
  AUTHORS   Watkins,D. and Rosenblatt,D.S.
  TITLE     Update and new concepts in vitamin responsive disorders of folate
            transport and metabolism
  JOURNAL   J Inherit Metab Dis 35 (4), 665-670 (2012)
   PUBMED   22108709
  REMARK    Review article
REFERENCE   5  (bases 1 to 1068)
  AUTHORS   van der Heijden,J.W., Oerlemans,R., Dijkmans,B.A., Qi,H., van der
            Laken,C.J., Lems,W.F., Jackman,A.L., Kraan,M.C., Tak,P.P.,
            Ratnam,M. and Jansen,G.
  TITLE     Folate receptor beta as a potential delivery route for novel folate
            antagonists to macrophages in the synovial tissue of rheumatoid
            arthritis patients
  JOURNAL   Arthritis Rheum 60 (1), 12-21 (2009)
   PUBMED   19116913
REFERENCE   6  (bases 1 to 1068)
  AUTHORS   Page,S.T., Owen,W.C., Price,K. and Elwood,P.C.
  TITLE     Expression of the human placental folate receptor transcript is
            regulated in human tissues. Organization and full nucleotide
            sequence of the gene
  JOURNAL   J Mol Biol 229 (4), 1175-1183 (1993)
   PUBMED   8445646
  REMARK    Erratum:[J Mol Biol 1994 May 13;238(4):639]
REFERENCE   7  (bases 1 to 1068)
  AUTHORS   Antony,A.C., Kane,M.A., Portillo,R.M., Elwood,P.C. and
            Kolhouse,J.F.
  TITLE     Studies of the role of a particulate folate-binding protein in the
            uptake of 5-methyltetrahydrofolate by cultured human KB cells
  JOURNAL   J Biol Chem 260 (28), 14911-14917 (1985)
   PUBMED   4066659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006229858.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211323.1, FM095247.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840112,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  165617618-165617744 c
            128-280             JAXUCZ010000001.1  165616147-165616299 c
            281-469             JAXUCZ010000001.1  165612865-165613053 c
            470-605             JAXUCZ010000001.1  165612642-165612777 c
            606-1068            JAXUCZ010000001.1  165612051-165612513 c
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1068
                     /gene="Folr2"
                     /note="folate receptor beta"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
     exon            1..127
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    65..67
                     /gene="Folr2"
                     /note="upstream in-frame stop codon"
     exon            128..280
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..892
                     /gene="Folr2"
                     /note="folate receptor 2 (fetal)"
                     /codon_start=1
                     /product="folate receptor beta precursor"
                     /protein_id="NP_001425256.1"
                     /db_xref="GeneID:293154"
                     /db_xref="RGD:1308515"
                     /translation="MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPED
                     KLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYEC
                     SPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGIN
                     KCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEV
                     VKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD"
     sig_peptide     134..193
                     /gene="Folr2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    218..745
                     /gene="Folr2"
                     /note="Folate receptor family; Region: Folate_rec;
                     pfam03024"
                     /db_xref="CDD:397250"
     misc_feature    218..745
                     /gene="Folr2"
                     /note="Folate receptor family; Region: Folate_rec;
                     pfam03024"
                     /db_xref="CDD:397250"
     exon            281..469
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..605
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1068
                     /gene="Folr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgtgct tacagagcct ctatgccggg ctgtggataa agactgtgaa gactgcacag
       61 ggtctgatct agggagaggc caactctgat acccctatgt gcgctgctag gagctaagga
      121 cattcagaga gacatggcct ggaaacagac accactcctg cttttggtct acatgatcac
      181 aacatgcagt gcccgggaca gaacagacct gctcaacgtt tgcatggatg ccaagcacca
      241 taagacaaag ccaggcccgg aggacaagct gcatgaccag tgtagtccat ggaagagaaa
      301 tgcctgctgc tcagtcaaca ccagccagga gctacacaag gacaactccc gtctgtacaa
      361 tttcaattgg gatcactgtg gtgagatgac gcccgcctgt aagcgtcact tcatccaaga
      421 cgcctgcctg tatgagtgtt cccccaatct tgggccttgg attcagcagg caggccagag
      481 ctggcgcaaa gagcgcttcc tggatgtgcc cttatgcaaa gaggactgtc aggagtggtg
      541 ggaagcctgt cgtacctcct ttacctgcaa gagagactgg cataaaggct gggactggac
      601 ctcaggcatt aacaagtgcc cagacacagc accctgccgc acatttcagt actatttccc
      661 gacaccagcc agcctttgtg agggtctctg gagtcactcc tacaaggtca gcaactatag
      721 cagagggagt ggccagtgca tccagatgtg gtttgactca acccagggca atcccaatga
      781 ggaagtggtg aagttctatg cttcctttat gacatctggg actgtgtacc atgcagcaat
      841 acttcttgtg cccagcctgg ccccagtgct gtcattatgg ctccctgact gaggccagtc
      901 ttctcctcta gctacccttg gtctcggttg gttcaactct tcaaagaata aggaagtctt
      961 gagcctgctt ccacccctct cctctgccat ccagttcctg atccatgttg gggcttgggg
     1021 tttctacaac aatcattttc aataaatcta tgacacatct cggcctaa
//
LOCUS       NM_001438258            4910 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus tudor domain containing 1 (Tdrd1), transcript
            variant 2, mRNA.
ACCESSION   NM_001438258 XM_063282788
VERSION     NM_001438258.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4910)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   2  (bases 1 to 4910)
  AUTHORS   Yamaji,M., Tanaka,T., Shigeta,M., Chuma,S., Saga,Y. and Saitou,M.
  TITLE     Functional reconstruction of NANOS3 expression in the germ cell
            lineage by a novel transgenic reporter reveals distinct subcellular
            localizations of NANOS3
  JOURNAL   Reproduction 139 (2), 381-393 (2010)
   PUBMED   19861488
REFERENCE   3  (bases 1 to 4910)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
REFERENCE   4  (bases 1 to 4910)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   5  (bases 1 to 4910)
  AUTHORS   Reuter,M., Chuma,S., Tanaka,T., Franz,T., Stark,A. and Pillai,R.S.
  TITLE     Loss of the Mili-interacting Tudor domain-containing protein-1
            activates transposons and alters the Mili-associated small RNA
            profile
  JOURNAL   Nat Struct Mol Biol 16 (6), 639-646 (2009)
   PUBMED   19465913
REFERENCE   6  (bases 1 to 4910)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
REFERENCE   7  (bases 1 to 4910)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
REFERENCE   8  (bases 1 to 4910)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063282788.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.9496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  265880949-265881004
            57-119              JAXUCZ010000001.1  265883848-265883910
            120-452             JAXUCZ010000001.1  265885603-265885935
            453-508             JAXUCZ010000001.1  265888925-265888980
            509-653             JAXUCZ010000001.1  265892382-265892526
            654-759             JAXUCZ010000001.1  265893680-265893785
            760-823             JAXUCZ010000001.1  265896331-265896394
            824-928             JAXUCZ010000001.1  265897265-265897369
            929-1111            JAXUCZ010000001.1  265897587-265897769
            1112-1255           JAXUCZ010000001.1  265898203-265898346
            1256-1427           JAXUCZ010000001.1  265898771-265898942
            1428-1514           JAXUCZ010000001.1  265899871-265899957
            1515-1682           JAXUCZ010000001.1  265902762-265902929
            1683-1790           JAXUCZ010000001.1  265903044-265903151
            1791-1961           JAXUCZ010000001.1  265903930-265904100
            1962-2204           JAXUCZ010000001.1  265905270-265905512
            2205-2342           JAXUCZ010000001.1  265905824-265905961
            2343-2453           JAXUCZ010000001.1  265908907-265909017
            2454-2624           JAXUCZ010000001.1  265909555-265909725
            2625-2897           JAXUCZ010000001.1  265912578-265912850
            2898-3017           JAXUCZ010000001.1  265914596-265914715
            3018-3134           JAXUCZ010000001.1  265915981-265916097
            3135-3302           JAXUCZ010000001.1  265918673-265918840
            3303-3530           JAXUCZ010000001.1  265920045-265920272
            3531-3577           JAXUCZ010000001.1  265920791-265920837
            3578-3670           JAXUCZ010000001.1  265920914-265921006
            3671-4910           JAXUCZ010000001.1  265923118-265924357
FEATURES             Location/Qualifiers
     source          1..4910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4910
                     /gene="Tdrd1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
     exon            1..56
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..119
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            120..452
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    134..136
                     /gene="Tdrd1"
                     /note="upstream in-frame stop codon"
     CDS             149..3670
                     /gene="Tdrd1"
                     /note="isoform 1 is encoded by transcript variant 2; tudor
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1 isoform 1"
                     /protein_id="NP_001425187.1"
                     /db_xref="GeneID:292129"
                     /db_xref="RGD:1306140"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKLPPHDSLRSPVPQHNHPN
                     FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTG
                     NPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRST
                     TCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLHKLEDNKSPFETK
                     TIDVKNEVACPLGVTKEMTAGAERVMFSDLRSLQLRKSMEIKGTVTEFKHPGHFYVQL
                     YSSEVLEYMNQLSASLKETYANMVPEDGYLPVKGEVCVAKYTVDQTWNRAVVEGVDVL
                     QKKAHVLYIDYGNEEIIPVDRIHQLSRSISLFPPSAIKCYVSGVVPAAGEWTEDCVVA
                     VKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYGVKPDEPSSKK
                     QSMDPGTSEDTGRLTAENRIGAERNALVPTVLTLNVGDEFCGVVAHIQTPEDFFCQQL
                     QSGHKLAELQESLSEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASVLAYASEESV
                     LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGMWTPEAICVMRKA
                     VQNRMVTVRVVGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEEKDIVADKGSSAR
                     ASNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALKKLDDLN
                     KSLADYCAQKPPNGFKAEVGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVV
                     EITENGVGVELTDLSTPYPKIISDVLITEHLVLRCGSPQKDELMSRPANKHNQIDSQS
                     VQASPPAEQWKTIELPVNKTVPANVLEIISPTLFYAIPSEMPENQEKLCVLTAELLEH
                     CNAQKGQPPYRPRTGEACCAKYTNDDFWYRAIVLEASDSDVKVLYADYGNVERLPFSR
                     VQPITASHLQLPFRIIRCSLEGLTELNGSSSQPVMELLRNAMLNQSVALSVKAVSKNV
                     HAVSVEKCSENGMINIAENLVMCGLAENLSSKRESASTKETPHSTDCCCTELQKQIEK
                     HEQILLFLLNNPTNQNKFIEMKKLLQS"
     misc_feature    632..742
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    632..742
                     /gene="Tdrd1"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:460312"
     misc_feature    929..1318
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    929..1318
                     /gene="Tdrd1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 1 (TDRD1) and similar proteins; Region:
                     Tudor_TDRD1_rpt1; cd20408"
                     /db_xref="CDD:410479"
     misc_feature    order(1097..1099,1118..1120,1172..1174,1181..1183,
                     1187..1189)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    order(1097..1099,1118..1120,1172..1174,1181..1183,
                     1187..1189)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410479"
     misc_feature    1679..1924
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    1679..1924
                     /gene="Tdrd1"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 1 (TDRD1) and similar proteins;
                     Region: Tudor_TDRD1_rpt2; cd20409"
                     /db_xref="CDD:410480"
     misc_feature    order(1784..1786,1805..1807,1856..1858,1865..1867,
                     1871..1873)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    order(1784..1786,1805..1807,1856..1858,1865..1867,
                     1871..1873)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410480"
     misc_feature    2270..2620
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2270..2620
                     /gene="Tdrd1"
                     /note="Tudor domain; Region: TUDOR; pfam00567"
                     /db_xref="CDD:425754"
     misc_feature    2957..3304
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    2957..3304
                     /gene="Tdrd1"
                     /note="Tudor domain superfamily; Region: Tudor_SF;
                     cl02573"
                     /db_xref="CDD:470623"
     misc_feature    order(3128..3130,3143..3145,3149..3151,3197..3199,
                     3206..3208,3212..3214)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     misc_feature    order(3128..3130,3143..3145,3149..3151,3197..3199,
                     3206..3208,3212..3214)
                     /gene="Tdrd1"
                     /note="putative peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:410449"
     exon            453..508
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..653
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..759
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..823
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..928
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1111
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1255
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1427
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1514
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1682
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1790
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1961
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2204
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2342
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2453
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2624
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2897
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3017
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3134
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3302
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3530
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3577
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3670
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..4910
                     /gene="Tdrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcgca ggcgcgggat caacagcacg cggcagcctt gagcgtccga ggcgaggtga
       61 aggcagcact ggatgtctga gcgtttgcag gtcaacacat gagtaagagt tgcaaaaaga
      121 cgtcagtgaa tgttaagtta catctaatat gatgccacga aataatttgg aagcctctac
      181 ttgtaaaatg gcagaaccat ttaattttga gaaaaaggaa agcaaacttc caccccacga
      241 ttctctaaga agtcctgtac cacagcataa ccatcccaat ttcagactga aaagcccaga
      301 gaacggaaat aaaaagaaca attttttgct ttgtgaacaa aacaaacagt acttggctag
      361 tcaggaagac aattcggtgg tctcttcaaa ccctgctggt atcaatggag aagtaggtgg
      421 gtccaaagga gacaggaaga cattaccaac aggaaaccca gtatcattaa gtcttggaaa
      481 caattcacca cctaaccaag taaaaactaa gcccagcaat gctgtgactc ctgaaaaatc
      541 aaaaaaatct cacaagctgt ttgagaatgc cttgtccgta aataacccag ctctcttcaa
      601 ctcgttagga ccgcccctgc ggtccacaac ctgccatcgc tgtggcctgt tcgggtcgct
      661 gaggtgttcc cagtgcaagc agacatatta ctgctccaca gcatgccaga ggagagactg
      721 gtcttcccat agcaccatct gtagacctgt gcagcaaagt ctgcataagc ttgaagataa
      781 taagtcacca tttgaaacaa agaccattga cgtgaagaat gaggttgcct gtcccctggg
      841 agttactaaa gaaatgacag ctggtgcaga gagagtaatg ttttctgatc tgaggagtct
      901 ccaactgagg aaatccatgg aaataaaggg cacagttact gaattcaagc acccgggtca
      961 tttttatgtc cagttgtatt cctcagaggt tttagagtac atgaaccaac tctctgcaag
     1021 tttgaaagag acatatgcaa atatggtgcc tgaagacgga tatcttcctg ttaaggggga
     1081 agtctgtgtt gccaagtaca cggttgatca gacctggaac cgagccgtag tagaaggcgt
     1141 ggacgtgctg cagaagaagg cacatgtctt gtacatcgac tacggaaatg aagagatcat
     1201 cccagtcgac agaatccacc agctaagcag aagtatcagc ctgtttcccc cttccgccat
     1261 aaagtgctat gtgtcaggag tcgtccccgc tgcgggtgag tggactgaag actgtgttgt
     1321 agctgtcaag gctctgctgt tcgagcagta ctgctctatc aaggtcgtgg acatctcaga
     1381 ggaggagggg ctcacctgtg ctgtcgacgt cgtgctgcag agttcaggaa aacagctgga
     1441 ccatgtgctt gtggaaatgg gatatggtgt gaaacctgat gagccgagct ccaagaagca
     1501 aagtatggac ccaggcactt cggaggacac tggaagactg acagctgaga acaggatcgg
     1561 ggcagagaga aatgccctgg tccccacagt gctgactttg aatgtgggtg acgagttctg
     1621 tggtgtagtt gcccacatcc agacaccaga ggacttcttt tgtcagcagc tgcagagtgg
     1681 ccacaagctc gccgagcttc aggagtccct cagtgagtac tgtagccacg tgactccacg
     1741 ctcagacttt tatccaacca ttggggacat gtgttgtgct cagttctcag aggatgacca
     1801 atggtaccgc gcctcggttc tggcctatgc ttcagaagaa tctgtcctgg ttggatatgt
     1861 cgattatgga aactttgaaa ttcttagttt gaaaagactt tgtcccataa ttccaaagtt
     1921 gttggatttg ccgatgcaag ctttaaattg tgtgctggca ggagtgaagc catctttagg
     1981 aatgtggact ccagaagcca tttgtgtcat gaggaaggct gtgcagaaca ggatggtgac
     2041 cgtgagagtg gtgggcatgc aggggaccag ggccctggtg gagctcgtag acaaatcggt
     2101 ggctcctcac ctcagcgctt ctaaagctct gctagactcc ggctttgcca tcgaggaaaa
     2161 ggacatagtg gcagataaag gcagcagtgc gcgtgcctcg aatgttccct tggctgtaga
     2221 aggagcagtg gaggtgctgg agtggacgtg ggtcgagttc accgttgacg agactgtgga
     2281 cgtgatggtc tgcatgatgc acagccctgg ggagttctac tgccactgtc tcaaagacga
     2341 cgccttaaag aagctcgatg acttgaacaa gtccttagca gactactgtg cacaaaaacc
     2401 gcccaatggc ttcaaggcag aggtagggcg gccttgctgt gcctgttttg caggtgacgg
     2461 caactggtac cgggctctgg tcaaggagat cctaccaagt gggaacgtca aagtacactt
     2521 tgtggactac ggcaatgttg aagaggttac cacagaccaa ctgcacgcaa tagcccccca
     2581 gttcttacta cttccgttcc aagggatgca gtgctggcta gtagatatac agcccaaaaa
     2641 caagcattgg acaaaagaag ccacagcaag atttcaagca tgtgtcgtgg ggcttaaact
     2701 tcaagccaga gttgtggaaa tcacggagaa tggggtgggc gttgaactca ccgatctttc
     2761 caccccctac cccaaaatca ttagtgacgt tctcatcaca gaacatctgg tcttaaggtg
     2821 tggttcacca cagaaggacg agttgatgag cagacctgct aataaacata accagatcga
     2881 ctcccagagc gtgcaagcca gccctcctgc agagcagtgg aagaccatag agttgccagt
     2941 taacaagact gtaccagcaa atgtactaga aatcataagc ccaaccttgt tttatgccat
     3001 ccccagtgaa atgccagaaa atcaagaaaa actgtgtgtg ttgacagctg aattgttaga
     3061 acactgtaac gctcagaaag gccagccacc ctacagacca cggacgggag aagcctgctg
     3121 tgctaaatac acaaatgatg acttctggta ccgggccatt gttctggaag cgtcagactc
     3181 tgatgtgaaa gttctctatg cagattatgg aaacgtggaa agactgcctt tttccagagt
     3241 gcagcccatc actgccagcc acctgcagct gcccttccgc atcattagat gctcacttga
     3301 ggggctgacg gagctgaacg gaagcagttc gcagccagtg atggagctgc tgaggaacgc
     3361 catgctgaac cagagtgtgg ctctctctgt gaaagcagtc tcgaagaatg tccatgcagt
     3421 gtcagttgaa aaatgttctg aaaatggaat gatcaatata gctgagaatc tggtgatgtg
     3481 tggcctggca gaaaacctct catctaaaag ggaaagtgct tcaactaaag aaacaccgca
     3541 cagcaccgat tgctgctgca cagagttaca gaaacagatt gagaaacacg aacagattct
     3601 cctcttcctc ttaaacaatc caaccaacca aaataaattt atagagatga aaaagctgct
     3661 gcaaagctaa aaacatcatc cctggggaaa aacactcggg aagaaggaga ccacaaaagc
     3721 cagactagag aaagaattgt atcttgtgtt tgttcgctgg aactgttgct tcctctcctt
     3781 tccttagtga cctttgacct caccacccct acttacttac cttgttctgt tgggtttgtt
     3841 gccctctccc tgattctttc cacaaaatac atgaatcttg cataagaggt tcatgtacta
     3901 gctaggcgtg gtggtgcaca cctgtaatcc cagccatgag cagaatgagg caagaagacc
     3961 tcaagttcaa ggccagcatg ggctacatag atagtttctc attacaaaca aaaccaaaca
     4021 tcaagattca aaaaatgtat gagacgacta ggaaggaaca tgaggtatct tctactaaga
     4081 gtgcgtgcat gagtgcgcgt atgcgtgtgt gtgtgtgtgt atttgctcta ctgagtatag
     4141 aagctagagc ctcccgtgtg ttaggcaagc tttccctctg agctacagtc ccagctctag
     4201 catctcgctg tccttgaaag gctgggtggc tgccctgggc gggcgggctt cagcatggtc
     4261 tgaacatcac aggcctctgc taatgagatg ctcttggtca tctgccgcct cgtcccctgc
     4321 tgggatctga ttggttcttt gcttctgggt gccatgcttc ctttgtgact tgtggccaag
     4381 gatgtgtgct gctgctctca tctgtgctga gacagcttgg cttttcatct tcgatcacag
     4441 cttcagtctt ggcactagga ggacactttc tgcccctgcc ctcagaggcc ctcctgggat
     4501 tgtctcacta gtctgtagtc attcagactt aagctctaga aataattcac tattttctca
     4561 aacacaaact ccagatatcg atttaaaaat ggagagcaca tttgtcatag ttcatgatca
     4621 cagattgtcc caaccttagc catgggcagc agtgtgtgcc ttcctgacag tcccatagtc
     4681 gctctggcaa ttgtcccacg gtttcagtgc tgtgcggcac tgtgacaact taatacaaca
     4741 tccccagcac tgatattgat gtgggtgggt ttgttccatt tccttttact ggcaatgtgt
     4801 gtcagctctt ctgttaaata ggacttctca cgtaaacagt tgcttgaatg ttgatgtgcc
     4861 tcaaacagct aagtttgtcc tgattcatcc agtaaactca cttgtcttca
//
LOCUS       NM_001109272             517 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus ciliogenesis and planar polarity effector complex
            subunit 2 (Cplane2), transcript variant 2, mRNA.
ACCESSION   NM_001109272 XM_001072545 XM_575943
VERSION     NM_001109272.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575943.2, XM_001072545.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132273,
                              SAMD00132297 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..517
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /note="ciliogenesis and planar polarity effector complex
                     subunit 2"
                     /db_xref="GeneID:500576"
                     /db_xref="RGD:1561421"
     exon            1..98
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    11..13
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /note="upstream in-frame stop codon"
     exon            99..248
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..451
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /note="isoform 2 is encoded by transcript variant 2; REM2
                     and RAB-like small GTPase 1; ciliogenesis and planar
                     polarity effector 2"
                     /codon_start=1
                     /product="ciliogenesis and planar polarity effector 2
                     isoform 2"
                     /protein_id="NP_001102742.1"
                     /db_xref="GeneID:500576"
                     /db_xref="RGD:1561421"
                     /translation="MARLPMHGSVIVPDWHETVEGKEYLACILRKNRRREFANSANRA
                     RNMETAHPCQQQLSPEMLLTESSLRVMPSAGHFAQQPCNRVSLCIQYSLLCIQYLLCR
                     PG"
     exon            249..517
                     /gene="Cplane2"
                     /gene_synonym="RGD1561421; Rsg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacagcgtc taggcctggc ggaagcaggc tctgcaggca gggcagaaga agggcgggct
       61 tttaaaagat cgtcaccctg ctagcgggga ctgtgaagta ttcggacaca cccttacctt
      121 gctaacttgc tcaaccatgg ccagacttcc catgcacggt tcggtgattg tcccagactg
      181 gcatgagacg gtcgagggca aggagtactt agcctgcatc ctgcgcaaga atcgccggcg
      241 tgagtttgct aattctgcca acagagccag gaacatggaa acagcccatc cctgccaaca
      301 gcaactgtca ccagagatgc tgttgactga gtcctcactt agggtcatgc cctctgctgg
      361 gcactttgca cagcaacctt gcaacagggt ttcgctatgt atccagtact cgttattgtg
      421 tatccagtac ttgttatgta gaccaggcta gtctcaaact caaaagatcc acctggcctt
      481 tatcttctaa atgctgggat taaaggcata ctccatt
//
LOCUS       NM_001438263            4098 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus beta-1,4-galactosyltransferase 5 (B4galt5), mRNA.
ACCESSION   NM_001438263
VERSION     NM_001438263.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Yoshihara,T., Satake,H., Nishie,T., Okino,N., Hatta,T., Otani,H.,
            Naruse,C., Suzuki,H., Sugihara,K., Kamimura,E., Tokuda,N.,
            Furukawa,K., Fururkawa,K., Ito,M. and Asano,M.
  TITLE     Lactosylceramide synthases encoded by B4galt5 and 6 genes are
            pivotal for neuronal generation and myelin formation in mice
  JOURNAL   PLoS Genet 14 (8), e1007545 (2018)
   PUBMED   30114188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Zhang,L., Ren,J., Shi,P., Lu,D., Zhao,C., Su,Y., Zhang,L. and
            Huang,J.
  TITLE     The Immunological Regulation Roles of Porcine beta-1, 4
            Galactosyltransferase V (B4GALT5) in PRRSV Infection
  JOURNAL   Front Cell Infect Microbiol 8, 48 (2018)
   PUBMED   29546034
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Li,S.F., Zhu,C.S., Wang,Y.M., Xie,X.X., Xiao,L.L., Zhang,Z.C.,
            Tang,Q.Q. and Li,X.
  TITLE     Downregulation of beta1,4-galactosyltransferase 5 improves insulin
            resistance by promoting adipocyte commitment and reducing
            inflammation
  JOURNAL   Cell Death Dis 9 (2), 196 (2018)
   PUBMED   29415997
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Mayo,L., Trauger,S.A., Blain,M., Nadeau,M., Patel,B., Alvarez,J.I.,
            Mascanfroni,I.D., Yeste,A., Kivisakk,P., Kallas,K., Ellezam,B.,
            Bakshi,R., Prat,A., Antel,J.P., Weiner,H.L. and Quintana,F.J.
  TITLE     Regulation of astrocyte activation by glycolipids drives chronic
            CNS inflammation
  JOURNAL   Nat Med 20 (10), 1147-1156 (2014)
   PUBMED   25216636
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Yamaji,T. and Hanada,K.
  TITLE     Establishment of HeLa cell mutants deficient in
            sphingolipid-related genes using TALENs
  JOURNAL   PLoS One 9 (2), e88124 (2014)
   PUBMED   24498430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Nishie,T., Hikimochi,Y., Zama,K., Fukusumi,Y., Ito,M., Yokoyama,H.,
            Naruse,C., Ito,M. and Asano,M.
  TITLE     Beta4-galactosyltransferase-5 is a lactosylceramide synthase
            essential for mouse extra-embryonic development
  JOURNAL   Glycobiology 20 (10), 1311-1322 (2010)
   PUBMED   20574042
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Wei,Y., Zhou,F., Ge,Y., Chen,H., Cui,C., Li,Q., Liu,D., Yang,Z.,
            Wu,G., Sun,S., Gu,J. and Jiang,J.
  TITLE     Beta1,4-galactosyltransferase V regulates self-renewal of
            glioma-initiating cell
  JOURNAL   Biochem Biophys Res Commun 396 (3), 602-607 (2010)
   PUBMED   20417617
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Yan,M., Cheng,C., Ding,F., Jiang,J., Gao,L., Xia,C. and Shen,A.
  TITLE     The expression patterns of beta1,4 galactosyltransferase I and V
            mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post
            sciatic nerve injury
  JOURNAL   Glycoconj J 25 (7), 685-701 (2008)
   PUBMED   18512149
  REMARK    GeneRIF: These results indicated that the expressions of
            beta1,4-GalT I, V mRNAs and Galbeta1-4GlcNAc group were involved in
            the process of denervation and reinnervation.
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Yan,M., Cheng,C., Shao,X., Qian,J., Shen,A. and Xia,C.
  TITLE     Expression change of beta-1,4 galactosyltransferase I, V mRNAs and
            Galbeta1,4GlcNAc group in rat sciatic nerve after crush
  JOURNAL   J Mol Histol 39 (3), 317-328 (2008)
   PUBMED   18320333
  REMARK    GeneRIF: beta1,4-GalT I and V might play important roles in the
            regeneration of the injured sciatic nerve.
            Erratum:[J Mol Histol. 2008 Aug;39(4):469. Xia, Chun [corrected to
            Xia, Chunlin]]
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Yan,M., Xia,C., Niu,S., Shao,X., Cheng,C., Zhao,J. and Shen,A.
  TITLE     The role of TNF-alpha and its receptors in the production of
            beta-1,4 galactosyltransferase I and V mRNAs by rat primary
            astrocytes
  JOURNAL   J Mol Neurosci 33 (2), 155-162 (2007)
   PUBMED   17917074
  REMARK    GeneRIF: These results suggest that an autocrine loop involving
            TNF-alpha, TNFR1 and TNFR2 contributes to the production of
            beta-1,4-GalT I and V mRNA in response to inflammation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.14680.1,
                                           SRR26643298.20390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000003.1  176488665-176488923 c
            260-394             JAXUCZ010000003.1  176452862-176452996 c
            395-508             JAXUCZ010000003.1  176447696-176447809 c
            509-633             JAXUCZ010000003.1  176446001-176446125 c
            634-750             JAXUCZ010000003.1  176445078-176445194 c
            751-938             JAXUCZ010000003.1  176444140-176444327 c
            939-1061            JAXUCZ010000003.1  176443491-176443613 c
            1062-1163           JAXUCZ010000003.1  176440551-176440652 c
            1164-4098           JAXUCZ010000003.1  176437068-176440002 c
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4098
                     /gene="B4galt5"
                     /note="beta-1,4-galactosyltransferase 5"
                     /db_xref="GeneID:362275"
                     /db_xref="RGD:1310062"
     exon            1..259
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="B4galt5"
                     /note="upstream in-frame stop codon"
     CDS             145..1311
                     /gene="B4galt5"
                     /EC_number="2.4.1.38"
                     /note="UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 5"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 5"
                     /protein_id="NP_001425192.1"
                     /db_xref="GeneID:362275"
                     /db_xref="RGD:1310062"
                     /translation="MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLF
                     MVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLDLNHSEAFPPTTTFL
                     PEDFTYFANHPCPERLPSMKGPIDINMSEIRMDDIHELFSRDPAIRLGGHWKPADCMP
                     RWKVAILIPFRNRHEHLPVLLRHLLPMLQRQRLQFAFYVIEQAGTQPFNRAMLFNVGF
                     QEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVS
                     GLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGE
                     VQFLGRYALLRKSKERQGLDGLNNLSYSANVTYDALYKNITVNLTPELAQVTEY"
     misc_feature    625..1275
                     /gene="B4galt5"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    625..1275
                     /gene="B4galt5"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; Region:
                     b4GalT; cd00899"
                     /db_xref="CDD:132999"
     misc_feature    order(649..651,655..657,661..663,766..768,844..852)
                     /gene="B4galt5"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(649..651,655..657,661..663,766..768,844..852)
                     /gene="B4galt5"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(844..846,850..852,1129..1131)
                     /gene="B4galt5"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     misc_feature    order(844..846,850..852,1129..1131)
                     /gene="B4galt5"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     exon            260..394
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            395..508
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..633
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            634..750
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            751..938
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1061
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1163
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..4098
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcccggc ccgcggcggc cggcggctga aagcggcgag gcggcggcgc gcgaagcccg
       61 gaaggcggcg accgaggccc aggcggcgaa ccggagcggc gggagcgggg cccgggtcgg
      121 ccctcgagcg gccgccggct cagcatgcgc gcccgccggg ggctgctgcg gctgccgcgc
      181 cgctccctgc tcgccgcgct cttcttcttc tcgctgtcgt cctcgctgct ctacttcgtc
      241 tatgtggcgc ccggcatagt gaacacctac ctcttcatgg tgcaggctca aggcatcctg
      301 cttcgggaca acgtgaggac catcggtgcc caggtgtatg agcaggtggt ccgcagcgcc
      361 tacgccaaga ggaacagcag cctgaatgac tcagattatc ctctggactt gaaccacagt
      421 gaagcctttc ccccaaccac aacatttctt cctgaagatt tcacctattt tgccaaccac
      481 ccttgcccgg agaggctccc ttccatgaag ggcccgatag acataaacat gagtgagatc
      541 agaatggacg atattcatga gctcttctcc agagacccgg ccatcaggct tggaggacac
      601 tggaagcctg cagactgcat gcctcggtgg aaggtggcca tcctcatccc tttccggaac
      661 cgccacgagc acctcccagt cctccttcga cacctgctcc ccatgctcca gcgccagcgc
      721 ctgcagtttg ccttctatgt gatcgagcaa gctggcaccc agccctttaa ccgagccatg
      781 ctcttcaacg ttggctttca agaagccatg aaggacttgg attgggactg tctgatcttc
      841 catgacgtcg atcacatacc tgagagtgac cgaaactact atggctgtgg acagatgccc
      901 aggcattttg caaccaaact agacaagtac atgtacctac ttccttacac agagttcttt
      961 ggcggtgtga gcggcctgac tgtggaacag ttccggaaaa tcaatggctt ccctaatgcc
     1021 ttctggggct ggggcggaga agatgacgac ctgtggaaca gggtacaaaa tgcaggctat
     1081 tctgtgagcc ggccagaagg ggacacagga aaatacaagt ccattcctca ccaccatcga
     1141 ggagaggtcc agtttcttgg caggtacgct ctgctgagga agtcaaagga gcggcaagga
     1201 ctggacggtc tcaacaatct gagctactct gctaacgtca cgtacgacgc cttgtataaa
     1261 aacataactg tcaacttgac acccgagctg gctcaggtga ctgagtactg agactcgagg
     1321 agaaaccaca cccacctacc cacccctcgg acaggctgtg atgcgccatc gtggggtcaa
     1381 cacaggagga cagaaagaga gtggagcaca ggaccacagg gctccagaaa actgtcacag
     1441 agcacatgca caaaggcctt cgctgcaggg cccaacaggg acaggagact tgaggacact
     1501 gtcatcagca ctggcttcta ttccacaaga cagatgtctg ccctgctgct ctcttccgtc
     1561 cacccaggtc ctgtctcagc tgcaacctcc agaattgcag ggccaggcta ggcgccccta
     1621 ggatagacgg atggccaagc ccagaggctt ccatggtcag ccagccctgg cttgaagcag
     1681 accggctatg ccggtctctg catctctgga gttctctttg gctttcattt ggtttagttt
     1741 agggtttttt tttttttctt ttctttttaa agaaattttt ctgctttagg tggggactga
     1801 gggcggaggg gaggaacttg gggtgataga cacataccag tcacttcttg aagaagtgca
     1861 gttgtaaata agccatgtaa gatgcctttt taaagtttaa ttttatagct ggctccactt
     1921 caaagtgaga gcttcacata ttaagatcac cttgggtggc aaacacaact tggttcccac
     1981 acagttgagt gccatctccc aagtcccagt catctaggaa ggaaatgaat gcagtccggt
     2041 ccttacagcc cctcttgtct gccctgcccc tcctttcctg cctctcccct cccttccttc
     2101 ctccttcccc ctctataggg tcttcctcct agagactcag cagctaagct ggaaatactg
     2161 ttcggggcac agtgctgtcc cctcttacag accccgagcc agccgggatg tgtaggggga
     2221 ggggaggcag aggcacaggg cacaggctta tcactccagt gtggctggca gggcctggag
     2281 aacaggagat ctgaggccag tgagctatgt cacaagttcc aagtcagcct gtgctgtgta
     2341 tgcagcccac tccagctcca catctcacat gcagagtggc tgttgggtga ctgttccctc
     2401 ttttctttgg aacttggcca cagtttctct gggccctgct tgcatgacca gctggcttca
     2461 gtgatttctc cgtttccctt tttagtttct aggaagctgc tgtgcttgtg ctaagaagcc
     2521 attggttggg gagggcacag ccagggagca ggtggcactg gggtgcatgg cggccagggt
     2581 ccaggtgagc tctcaccaga tccttgacag gcggcccagc agtccccctg cttcctgaca
     2641 tcagctccta aagggcacct ccttcctgaa ccagagctcc ttcctgtgtc tgcctccctg
     2701 cagcctctgt ccctgaagca gggatctgtg tgtggcgagg agcgttctcc tctggcctct
     2761 gctcttcgcc tttttgcctt cagcaccctt gatgttcatg gtttacatgg gtgggggtgg
     2821 ggtgtagata cacggggatg gggtttacat cacacagttg gttctgagga cagatgatcc
     2881 ccacagactg tgggagtgat tggccaggcc tttttttttg ttctttttgt agagtagagt
     2941 ggtatctagg gaacagatgg cgctgcagag cgcttcccgc tcgtatgaga gagcaggtgc
     3001 ctgcccttga gagcgctggt gaaccacgtc atctgtttgc actgggcaag gagctgcacg
     3061 aggcgctgcg ttgacttgcc tttgtcttac ggtacacaca gcaataaaga ttgggttccg
     3121 cctgcccggc tcaaccctct gccccctgtg ttagttttac agtgcgggga aggaaaccca
     3181 tggctgatgt gctaggcaag agctctgcca ctgagtcacg ggtccagccc cctctcccct
     3241 catccttctg tttccactct gaaggtcagg gatgctgtcg ctgtggtaga gccttggtgt
     3301 ccttggaggg acagtggtgt gtgtagcatg tgtcctggct gaagccctgc atcctcacaa
     3361 tagccacagg gcaccttttt aagccaaagg ctgatacttg atttaagaag gaaaatgcag
     3421 atttggggac aaagaaaggt ctttttactg ctcaagtcgg gtcacttatg ttcccttgca
     3481 atcatgtcca agtttgttat tagtgtggac tcttgtgggc actgtcagtc attgtccgcc
     3541 cagtcacata ccgagtggga aatgtcacag tcagagccac accactggac cacacattag
     3601 gtcattgctt aaagaaaatg acattgagaa tcaagtgtga ccttggtgta ctttggcagc
     3661 tgaaattact ccatgctaca gacgagtgac ccttaagccg acctgccctt gactgactgc
     3721 cctgtgtgtg caaggtctct ctccgcacag gctttctttg gggagggggg atttgcaaaa
     3781 ctttaatttt gctaaaatgg ggactcctgt catcgagttc cttcctcaga gcggcagagc
     3841 acacactgac tgtgcctacc atcgacgagg cactgacgcc actggcttag ccaccattac
     3901 tgtctttgtt ctgagcttgc tctttgtttt aaaggtgcca gggggacatt tttgcactga
     3961 agcctaaaga tgttttaaaa acacttttca cagaaatagt ccttgtcatt acattgttca
     4021 ctcatgtgtt tgtacatttt tgtatgttaa tttatgaatg attttttcag taaaaaatac
     4081 atattcaata accaaacc
//
LOCUS       NM_001438291            1258 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide A
            (Snrpa), transcript variant 2, mRNA.
ACCESSION   NM_001438291 XM_006228564
VERSION     NM_001438291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1258)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1258)
  AUTHORS   Kondo,Y., Oubridge,C., van Roon,A.M. and Nagai,K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1258)
  AUTHORS   Bai,B., Hales,C.M., Chen,P.C., Gozal,Y., Dammer,E.B., Fritz,J.J.,
            Wang,X., Xia,Q., Duong,D.M., Street,C., Cantero,G., Cheng,D.,
            Jones,D.R., Wu,Z., Li,Y., Diner,I., Heilman,C.J., Rees,H.D., Wu,H.,
            Lin,L., Szulwach,K.E., Gearing,M., Mufson,E.J., Bennett,D.A.,
            Montine,T.J., Seyfried,N.T., Wingo,T.S., Sun,Y.E., Jin,P.,
            Hanfelt,J., Willcock,D.M., Levey,A., Lah,J.J. and Peng,J.
  TITLE     U1 small nuclear ribonucleoprotein complex and RNA splicing
            alterations in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16562-16567 (2013)
   PUBMED   24023061
REFERENCE   4  (bases 1 to 1258)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   5  (bases 1 to 1258)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 1258)
  AUTHORS   Novakova,Z., Man,P., Novak,P., Hozak,P. and Hodny,Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   7  (bases 1 to 1258)
  AUTHORS   Sinha,K., Perumal,K., Chen,Y. and Reddy,R.
  TITLE     Post-transcriptional adenylation of signal recognition particle RNA
            is carried out by an enzyme different from mRNA Poly(A) polymerase
  JOURNAL   J Biol Chem 274 (43), 30826-30831 (1999)
   PUBMED   10521474
REFERENCE   8  (bases 1 to 1258)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1258)
  AUTHORS   Nagai,K., Oubridge,C., Jessen,T.H., Li,J. and Evans,P.R.
  TITLE     Crystal structure of the RNA-binding domain of the U1 small nuclear
            ribonucleoprotein A
  JOURNAL   Nature 348 (6301), 515-520 (1990)
   PUBMED   2147232
REFERENCE   10 (bases 1 to 1258)
  AUTHORS   Craft,J., Mimori,T., Olsen,T.L. and Hardin,J.A.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228564.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.335535.1,
                                           SRR26643299.1724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000001.1  91617980-91618157   c
            179-270             JAXUCZ010000001.1  91617449-91617540   c
            271-443             JAXUCZ010000001.1  91615046-91615218   c
            444-620             JAXUCZ010000001.1  91613872-91614048   c
            621-794             JAXUCZ010000001.1  91611727-91611900   c
            795-883             JAXUCZ010000001.1  91611264-91611352   c
            884-1258            JAXUCZ010000001.1  91609419-91609793   c
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1258
                     /gene="Snrpa"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
     exon            1..178
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            179..270
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    183..185
                     /gene="Snrpa"
                     /note="upstream in-frame stop codon"
     CDS             198..1043
                     /gene="Snrpa"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_001425220.1"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
                     /translation="MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIL
                     VSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFV
                     ERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMTQAPRIMHHMPGQP
                     PYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEET
                     NELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKI
                     SFAKK"
     misc_feature    216..482
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    216..482
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    <231..>818
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    <231..>818
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    order(234..236,240..245,252..254,327..329,333..335,
                     339..359,363..365,435..437,444..446,450..473)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    order(234..236,240..245,252..254,327..329,333..335,
                     339..359,363..365,435..437,444..446,450..473)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    783..1040
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     misc_feature    783..1040
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     exon            271..443
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            444..620
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            621..794
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            795..883
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1258
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgttctt ttcctgggca ggcactgagg cccgggaaga gacttattct gaacttacgg
       61 agtttgcggg ccctgattag ctcgcggaag ggggtagccg gaaccaggga agaaagaagc
      121 tgtgtgtctt tgcagcgtag cttggcgggc gctgtcggtc tgagcgacgg cttaggtgta
      181 cctgaacatc tcacaccatg gcagttcccg agacccgtcc caaccacact atttatatca
      241 acaatctcaa tgagaagatc aagaaagatg agctcaagaa gtccctgtat gccatcttct
      301 cccagtttgg ccagatcctg gatatcctgg tgtctcggag cctgaagatg aggggccagg
      361 ccttcgtcat cttcaaggag gtcagcagtg ccaccaacgc cctgcgttcc atgcagggct
      421 tccctttcta cgacaagccc atgcgtatcc agtacgcaaa gactgactca gacatcattg
      481 ccaaaatgaa gggcaccttt gtggagagag atcgcaaacg tgagaagagg aagcccaaga
      541 gtcaggagac acctgctgcc aaaaaggctg ttcagggtgg ggcagctgcc cctgtggttg
      601 gcgctgtcca gcctgtaccg ggcatgccac cgatgactca ggcaccccgc atcatgcacc
      661 acatgccagg acagcctccc tacatgccac cacctggcat gatcccgcca ccaggccttg
      721 ctcctggcca gatccctcct ggggcaatgc ccccacagca gctcatgcct gggcagatgc
      781 cacctgccca acctctctcg gagaatccac ccaatcacat cctgttcctc accaacctgc
      841 ctgaggagac caacgagctc atgctctcca tgctcttcaa ccagttccct ggcttcaagg
      901 aggtgcgtct ggtccctggg cgccatgaca ttgccttcgt ggagtttgac aatgaagtgc
      961 aggctggggc agcacgagat gccctgcaag gcttcaagat cacacagaac aatgcaatga
     1021 agatctcttt tgccaagaag tagcaccttt ccctacggag tgccccagtc cccattctgg
     1081 ggctgcccct tccccctctc ttggctcagt ccctgaaggt aagtccccct tgggggcctt
     1141 ctcagagccg tgagtgagtg tgtgtctgcc acacagcatt gtacccaggg tcttcccaga
     1201 cattgcacct ggcgctgttg ggttgtgatt aaagtgagtt tttaggtttg gtttttca
//
LOCUS       NM_001438251            3423 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), transcript variant 1, mRNA.
ACCESSION   NM_001438251 XM_006227813
VERSION     NM_001438251.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 3423)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 3423)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 3423)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 3423)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006227813.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.433.1, SRR26643298.569.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  36695465-36695513
            50-214              JAXUCZ010000001.1  36696423-36696587
            215-368             JAXUCZ010000001.1  36697967-36698120
            369-486             JAXUCZ010000001.1  36699898-36700015
            487-865             JAXUCZ010000001.1  36702233-36702611
            866-991             JAXUCZ010000001.1  36703970-36704095
            992-1145            JAXUCZ010000001.1  36705450-36705603
            1146-1234           JAXUCZ010000001.1  36706668-36706756
            1235-1415           JAXUCZ010000001.1  36707831-36708011
            1416-1458           JAXUCZ010000001.1  36709666-36709708
            1459-1645           JAXUCZ010000001.1  36722626-36722812
            1646-1764           JAXUCZ010000001.1  36723647-36723765
            1765-1857           JAXUCZ010000001.1  36724215-36724307
            1858-2043           JAXUCZ010000001.1  36724407-36724592
            2044-3423           JAXUCZ010000001.1  36726431-36727810
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..3423
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..49
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            50..214
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    74..76
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="upstream in-frame stop codon"
     CDS             86..2188
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methionine synthase reductase; aqCbl reductase;
                     aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase isoform 1"
                     /protein_id="NP_001425180.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKY
                     DLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDFFAHLWYGLLGLGDSEYT
                     YFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPWIDGLWPALTKHFKSLGGQ
                     EDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSELQEQNETNKNQP
                     SRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQ
                     VPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQL
                     ADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDY
                     TSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQ
                     PRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEV
                     LTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQ
                     HPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPA
                     KYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAM
                     KTLATLKQEKRYLQDIWS"
     misc_feature    101..511
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    101..511
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Region: Flavodoxin_1; pfam00258"
                     /db_xref="CDD:425562"
     misc_feature    587..826
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498R1.2);
                     Region: Hinge. /evidence=ECO:0000250"
     misc_feature    602..604
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBK8; propagated from
                     UniProtKB/Swiss-Prot (Q498R1.2); phosphorylation site"
     misc_feature    653..655
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBK8; propagated from
                     UniProtKB/Swiss-Prot (Q498R1.2); phosphorylation site"
     misc_feature    917..2182
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    917..2182
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="Human methionine synthase reductase (MSR) restores
                     methionine sythase which is responsible for the
                     regeneration of methionine from homocysteine, as well as
                     the coversion of methyltetrahydrofolate to
                     tetrahydrofolate. In MSR, electrons are transferred...;
                     Region: methionine_synthase_red; cd06203"
                     /db_xref="CDD:99800"
     misc_feature    order(1439..1450,1493..1498,1547..1558,1661..1663,
                     2180..2182)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1439..1450,1493..1498,1547..1558,1661..1663,
                     2180..2182)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1439..1441,1445..1450)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1439..1441,1445..1450)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1448..1450,2039..2041,2174..2176,2180..2182)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1448..1450,2039..2041,2174..2176,2180..2182)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:99800"
     misc_feature    order(1499..1510,1721..1723,1727..1729,1826..1831,
                     1916..1921,1961..1963,1967..1969,2057..2059)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1499..1510,1721..1723,1727..1729,1826..1831,
                     1916..1921,1961..1963,1967..1969,2057..2059)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="NAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1547..1549,1556..1558,1565..1567)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1547..1549,1556..1558,1565..1567)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="phosphate binding motif [ion binding]; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1712..1714,1724..1735,1739..1741)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     misc_feature    order(1712..1714,1724..1735,1739..1741)
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="beta-alpha-beta structure motif; other site"
                     /db_xref="CDD:99800"
     exon            215..368
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            369..486
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            487..865
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            866..991
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1145
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1234
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1415
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1458
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1645
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1764
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1857
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2043
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..3423
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacggtatc tgagaaaaac ggggacccgc gcggaattcg caccaggagt ctcactgttg
       61 gagttacagc tgatgacctg aggtgatgag aaggtttttg ttactgtatg ctacacagcg
      121 agggcaggca aaggccatag ctgaagaaat aagtgagcag gctctgtcac acgggttttc
      181 cgcagatctt cactgcgtca gtgagtcaga aaagtatgat ctgaaaaccg aaactggccc
      241 tctggtgatg gttgtatcta ccacgggtac tggagaccca cccgacacag cccgcaagtt
      301 tgtgaaagaa atacacaaca agacactacc cacagacttc tttgctcacc tgtggtatgg
      361 attattgggt ttgggtgact cagaatacac atacttctgc aatggaggga aagtaattga
      421 taaacgactt caggagcttg gagcccagca tttctatgac actggacatg ccgatgactg
      481 cgtaggttta gagctcgtgg tagaaccatg gattgatgga ctctggcctg ctctcacaaa
      541 gcactttaag tcactcggag gacaagaaga catgagtgac agtgacacac tcgcacaggc
      601 atcagatgcc cccttgagta tggccatgaa gccagagttg ttgcacatcc agtcacaagt
      661 tgaacttcta agtttagaag acgtggggaa aagggattct gagcttcagg aacaaaatga
      721 gaccaacaag aatcagccaa gtcggatcga agactttgac tcttcgcttg ttaactcggt
      781 tcccccactc tcacagagct ctctaagtat tcctgctgtg tccccagaat atttggaggt
      841 ctatcttcag gagtctcttg gccaggatga aaaccaagca tctgtgccac catcagtcga
      901 tccaattttt caagttccaa tttcaaaagc tgttgagctg actacaaacg atgccataaa
      961 gaccactctg ctgttggaat tggacatctc aaaagtagag ttttcccatc aacctggaga
     1021 ttccttcaat gtgatctgtc caaacagtgg ttctgaagta gaagacttgc tgcaaaggct
     1081 gcagctggct gacaaacaag cacaccgggt catcctgaaa attaagatgg acaccaagaa
     1141 gaaaggagct tctctgcccc agcatgtgcc tgaggggagt tctctccagt tcatcttcac
     1201 ctggtgtctt gaaatacgag cagttcctaa aaaggctttt ttgagggccc tttcggatta
     1261 caccagcgat gccactgaaa agcggaggct tcaggagctc tgcagtaagc agggagcagc
     1321 tgattacaac cgcttcatcc gagatgccag tgtctgcctg ctagacctcc tgcttacctt
     1381 cccatcctgc cagcctccgc tcaacctcct gctggagcac cttcctaaac tccagcctcg
     1441 accatactcg tgcgcaagct ccagcttact ccatccagac aagcttcact ttgtgtttaa
     1501 catcgtagag cttccgtcga acaccactgc agcctcactg cggaagggag tgtgcacagg
     1561 ctggctagcc acattggttg ctccatttct tcagccaaac acagaagttt tgactgcaga
     1621 ccatagtgat gctctggctc ctgagatact tatctctcct cgggcaacaa attccttcca
     1681 cttaccagat gacctgtcgg cccccatcat aatggtgggt ccaggaactg gtgtagcccc
     1741 ctttgttggc ttcctgcagc acagagaaaa actccaagaa caacacccag acggaaactt
     1801 tggagcaatg tggctgtttt ttggctgcag acataaggac agagactatt tgttcaggga
     1861 ggagctcagg catttcctca agactggggt cttgactcac ctgaaggtct cattctcaag
     1921 agatgctgcg cctgaggaag aggaggaggc cccagcaaag tatgtgcaag acaacctcca
     1981 gcatcacagc cagcaggtgg ccaggaccct ccttcaggag aatggctaca tttacgtgtg
     2041 tggagacgcc aagaatatgg ctaaggatgt acacgacgcc cttgtagaaa tcataagcaa
     2101 agaagctgga gttgacaaac tagaagcaat gaagacactg gcaaccttaa agcaagaaaa
     2161 gcggtatctg caggatatct ggtcgtgaaa ctagaaggga ggtttcagtg tgcttgcttg
     2221 cttgtttgtt ttttgaaatg ccaaaggaca gttgtacaga agataggttt tgggtatttc
     2281 ttggcagagg ctttgtgggg aacagctcac ttacaggtac caccgcctga tacaatctca
     2341 ggtttgtctc ccactctgtg tcccacccag caccccactg tgtggagcgg agaggcagct
     2401 ctcagctggc tcccaaggag gacagatagt cgtcaatggc tctgggcaca tcgtggagag
     2461 tttgtggaca tgttctcttt caatgaagta cattcagagg atattcattc tgatgatatt
     2521 taaattaata cagacataca gagcatactt ttgcatgttt gcacttaatt gtggtttatt
     2581 atcaaaatta tatttctgat aaaatatttt aattttgagg taatccttac aaaataaggg
     2641 tttttatgct actagaaata tattttgaaa tacaattgaa attgtgctct gccattttca
     2701 tcatgttaac ttttagtgtc acagtcctac agcttagggg catttgcatt cccctgacaa
     2761 aggcatgtgt gtacatctca gtaacatcat gccctgttct cctggactct attcatcaat
     2821 gctcctcact aacagacttg gtattcccca atacctgact gtacttctgt gattcagctc
     2881 agagtaaaga gctccagtta gacttctaat accaaattct cttgcaagtt tcgaaaataa
     2941 agcatataaa aggattctgt gccattgtgt gtatggttgc tgagacaaaa ctgggacaaa
     3001 gcaacttaat gagagatggt atttctgctc acagttccag tatgtggtcc atggtgctgg
     3061 tgaagtcatg gtggcagaag gagaagacaa ctggtcatgt tacatccagt cagaaggaaa
     3121 cgacatgcat gcctcactgg ctttctcctt ttcacacaca ctgtctagaa ctttcacaca
     3181 cagaatgggt ctgcctacat gtactgtggg tgttcacctc agcgtagtcc agaggacctc
     3241 tcagcagtgg tttgtctcca gtgaggccac agccatcaca tgcatgataa actctccatt
     3301 cagtgtatag ttattgtctt gtttaatagt tcaacattta aaacacaact ctgcctggtg
     3361 agatgtcact aagagactcc ctggtcatta taagaattaa agatttgaaa aaataatctc
     3421 aaa
//
LOCUS       NM_001438314            3741 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), transcript variant 1, mRNA.
ACCESSION   NM_001438314 XM_008759510
VERSION     NM_001438314.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 3741)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 3741)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 3741)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 3741)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 3741)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 3741)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_008759510.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3956.1,
                                           SRR26360176.473174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-780               JAXUCZ010000001.1  144815553-144816332 c
            781-955             JAXUCZ010000001.1  144794240-144794414 c
            956-1144            JAXUCZ010000001.1  144734138-144734326 c
            1145-1368           JAXUCZ010000001.1  144723344-144723567 c
            1369-1621           JAXUCZ010000001.1  144721538-144721790 c
            1622-1735           JAXUCZ010000001.1  144719060-144719173 c
            1736-1825           JAXUCZ010000001.1  144718672-144718761 c
            1826-1962           JAXUCZ010000001.1  144717593-144717729 c
            1963-2161           JAXUCZ010000001.1  144714015-144714213 c
            2162-2256           JAXUCZ010000001.1  144712661-144712755 c
            2257-2337           JAXUCZ010000001.1  144711957-144712037 c
            2338-3741           JAXUCZ010000001.1  144709278-144710681 c
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..3741
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..780
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    337..339
                     /gene="Cpeb1"
                     /note="upstream in-frame stop codon"
     CDS             652..2436
                     /gene="Cpeb1"
                     /note="isoform 1 is encoded by transcript variant 1; CPEB;
                     CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 1"
                     /protein_id="NP_001425243.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MAPLKLSIRAPRAGRALSEPGEVTWLHTFDCFWSPSPEGGPDQE
                     EESGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSLDFSKVCTTPINRGIHDQLPD
                     FQDSEEAITSRMLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSSAQS
                     NTQSVLSMLQNPLGNVLGKTPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDSRSS
                     SPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQEQAA
                     LAAVAPSPTSAPKRWPGTSVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCTWSG
                     QLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKG
                     YVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNF
                     VWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRV
                     TFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFK
                     YFCRSCWHWRHSMEGLRHHSPLMRNQKN"
     misc_feature    775..1683
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    775..1683
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     1 N-terminus; Region: CEBP1_N; pfam16368"
                     /db_xref="CDD:465107"
     misc_feature    1687..1995
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    1687..1995
                     /gene="Cpeb1"
                     /note="RNA recognition motif 1 (RRM1) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM1_CPEB1; cd12723"
                     /db_xref="CDD:410122"
     misc_feature    2026..2277
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    2026..2277
                     /gene="Cpeb1"
                     /note="RNA recognition motif 2 (RRM2) found in cytoplasmic
                     polyadenylation element-binding protein 1 (CPEB-1) and
                     similar proteins; Region: RRM2_CPEB1; cd12725"
                     /db_xref="CDD:410124"
     misc_feature    2257..2424
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     misc_feature    2257..2424
                     /gene="Cpeb1"
                     /note="Cytoplasmic polyadenylation element-binding protein
                     ZZ domain; Region: CEBP_ZZ; pfam16366"
                     /db_xref="CDD:465105"
     exon            781..955
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1144
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1368
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1621
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1735
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1825
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1962
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2161
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2256
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2337
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..3741
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctcgct gcaaaaatag tgcccacgtg tgtgcgcgtc ccgcgccgca cagacccgcc
       61 ggcccgcccg ccagtccctt agggccacgc cggaccccat ggctttttct ctggtaagag
      121 ccgccggggc ggggcggggc cgggcggggc tgctgtccct gccgcctcag ctaacggtcc
      181 gcgcgcagtc tcgctgcctc acaggccccc accgccgccc gggttagcgt cccgggcggg
      241 gcgccggtca catgcccgcg gtcgtgggcc tcgtggagcg gtgtggggcg cgcggggagg
      301 ggcagggagc ctcctcgtga ctcaggcctt tgggcttaaa ggcgccgcgg ccctccgggg
      361 gcggccgctg gggcctcgga gctgcgcttg cagactctcg gtggcttcga acatacgtcc
      421 agaccggagc tggcggcgcg gacgggagcc cgggcgccca caacagttcc tcctcccgca
      481 gccgtcgcac gtgagagccc gagcggccgg cagtgccggc gtctctcgag agtcgccttg
      541 gcgtcccgca ggagacagga gccggcggct cgctgcgggc cgcacagtga gcagcggaga
      601 ccccctcagg ctgggtccgc gctgggggag gcgcgccacg acggcgccga catggctcct
      661 ttaaagctga gtattcgggc ccctcgtgcg ggccgcgcgc tttccgagcc cggggaagtc
      721 acgtggcttc acacgttcga ttgcttctgg agccctagcc ctgagggtgg accggaccag
      781 gaagaagaat caggaaggat aaaggactgc tgggacaacc aagaggttcc tgcactctct
      841 acatgtagca atgccaatat ctttcgaagg ataaatgcca ttttggatga ttcactggac
      901 ttcagtaaag tctgcacaac acctataaat cgaggaattc atgatcagtt gccagacttc
      961 caggactctg aagaagcaat tacaagcagg atgcttttcc ccacctctgc gcaagaatct
     1021 ccccgcggcc tcccagatgc aaacggtttg tgccttggcc tgcagtcact cagtctgact
     1081 ggctgggacc gaccctggag cacccaggac tcagactcct cagcccagag caacacacag
     1141 tcagtattaa gcatgctcca aaatccactg ggaaatgtct taggaaaaac ccccttgagc
     1201 ttcctgtctc tggatcccct tgggtctgac ttggacaagt tcccagcgcc ctcagttaga
     1261 ggatctcgcc tggacacccg gcctatcctg gactcccgtt ctagcagccc ctctgactca
     1321 gacacgagtg gcttcagctc tggatcagat catctctcag atttgatttc aagccttcgc
     1381 atttcccctc ctctgccctt tctttctatg acgggaaatg gtcccagaga ccctctaaag
     1441 atgggagttg ggtctcgaat ggaccaagag caagctgctc ttgctgcagt tgctccctct
     1501 ccaaccagtg ctccaaagag atggccagga acttctgtgt ggccatcttg ggaccttctc
     1561 ggagctccta aagacccatt cagcatagag agagaggcta gactccacag gcaggccgca
     1621 gctgtgaatg aagctacatg tacctggagt ggccagcttc ctccccggaa ctacaagaac
     1681 cccatctact catgcaaggt gttcctagga ggtgttcctt gggacattac agaagctgga
     1741 ttggttaaca ccttccgtgt ttttggctct ctgagtgtgg agtggcctgg taaggatggc
     1801 aagcaccccc ggtgtcctcc caaagggtat gtgtatttgg tgtttgaact agagaagtcc
     1861 gtccgggcct tgcttcaggc ttgttctcat gacccactga gcccagatgg cctaagtgaa
     1921 tattatttca agatgtccag ccgaaggatg cgctgcaaag aagtacaggt aatcccttgg
     1981 gtcttggctg acagcaactt tgtctggagc ccatctcaga ggctggatcc cagcaggacg
     2041 gtgtttgttg gtgccttgca cgggatgctc aatgctgagg ctctggctgc catcttgaat
     2101 gacctatttg gtggagtggt gtatgctggg attgacacag ataagcacaa gtaccccatt
     2161 gggtctggtc gtgtgacttt caataaccaa cgtagttacc tgaaagcagt cactgctgct
     2221 tttgtggaga tcaaaaccac caagtttacc aagaaggttc agatcgaccc ctatctagaa
     2281 gattctctgt gtcttatctg cagttcacaa cctggtcctt tcttctgccg agatcaggtc
     2341 tgcttcaagt acttttgccg aagctgctgg cactggcgac acagcatgga aggcctacgc
     2401 caccacagcc cgctaatgag gaaccagaag aactaaaatt ccagctagag aagctggcct
     2461 ggcccagggc ctgtggcgcc aaaggctggc aagtcaggca gcagcctgtt ccctgcacgg
     2521 gcgcctagga gctagctttc tgcagacaag ggagaattgt actcaccttt gtacttgctg
     2581 agtctgtctt tgtttctgca ctaattaatg cacaatgagt tttgtcaggt tttgtcttca
     2641 gcggggtgtg ccagagcagg ggcctcaggc tcaccctcaa gcaattgtag ttttcccaga
     2701 ttctagttcc tcattttgca aatgaaaaca acaaaaaaaa ctgtgtctag aacgcgttga
     2761 cacagatgcc tacacttggg tttatttatt aaagcgcttc ttacattcct tgcaatactg
     2821 atggtggtga tgcgcaggtc tcattggtcc attcttgcag ttgccataca gtgcctttcc
     2881 atttatttaa cccccacctg aacggcataa attgagtgtt cagctggtgt tttttactgt
     2941 aacaaacaaa ggagactttg ctcttcattt aaaccaaatc atatttcata gtttacgctc
     3001 gagggttttt actggttcct ttttacactc cttaaaacag tttttaagtc gtttggaaca
     3061 atagattttt ttttcttttt tggcagcttt taacattata gcaaatttgt gtctggggga
     3121 ctgctggtca cagttgcaaa tcaaagcatt tgtaaccaag agaaaaatta ttttatttaa
     3181 aactggatgg gaggaaaaat taggtctgag cagctgctgt atatagtttt aaatggtttg
     3241 tcgcacctta tgttgcactt acgttggggg agggttgata gaagttttta atcacagtca
     3301 caggactttt tcttttgtaa ctgagcttaa aaattaaaaa aaaaaaaagg gctgcttttt
     3361 ggtgggggcg gatgaaggct cacaggagcc ctttctctta gaggggcaag tacccttcct
     3421 tacaactttt atttgaagaa tgtatgaatc aacagttatt gttgacaaaa atgttactgg
     3481 aattgaaaac ttgactcttt ttttaaaaat ttagttacta cttgcccctc ttagggaagc
     3541 tgtgtgccaa agaaccagtg tcgcccccct gctgagctga cgttgcattg tcgcatatcc
     3601 cagctactct gtgggctcgt gaagctgtgt gtgaagtctc tacctcattg ttgtacatgc
     3661 aggcaagact gcactctgta cagattgtgg agtaagctgt ggtgtacttt ttttggcaca
     3721 taataaacac gttgcagcag a
//
LOCUS       NM_001438303            3123 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus ring finger protein 220 (Rnf220), transcript
            variant 2, mRNA.
ACCESSION   NM_001438303 XM_017593797
VERSION     NM_001438303.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Ma,P., Yang,X., Kong,Q., Li,C., Yang,S., Li,Y. and Mao,B.
  TITLE     The ubiquitin ligase RNF220 enhances canonical Wnt signaling
            through USP7-mediated deubiquitination of beta-catenin
  JOURNAL   Mol Cell Biol 34 (23), 4355-4366 (2014)
   PUBMED   25266658
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced XM_017593797.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JAXUCZ010000005.1  136197677-136198022 c
            347-1088            JAXUCZ010000005.1  136190568-136191309 c
            1089-1221           JAXUCZ010000005.1  136012745-136012877 c
            1222-1267           JAXUCZ010000005.1  136004531-136004576 c
            1268-1369           JAXUCZ010000005.1  136000843-136000944 c
            1370-1412           JAXUCZ010000005.1  135993033-135993075 c
            1413-1534           JAXUCZ010000005.1  135989870-135989991 c
            1535-1667           JAXUCZ010000005.1  135989404-135989536 c
            1668-1764           JAXUCZ010000005.1  135981970-135982066 c
            1765-1851           JAXUCZ010000005.1  135981716-135981802 c
            1852-1907           JAXUCZ010000005.1  135981554-135981609 c
            1908-1986           JAXUCZ010000005.1  135981364-135981442 c
            1987-2095           JAXUCZ010000005.1  135977575-135977683 c
            2096-2170           JAXUCZ010000005.1  135977386-135977460 c
            2171-3123           JAXUCZ010000005.1  135975738-135976690 c
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3123
                     /gene="Rnf220"
                     /note="ring finger protein 220"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
     exon            1..346
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1088
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    437..439
                     /gene="Rnf220"
                     /note="upstream in-frame stop codon"
     CDS             464..2242
                     /gene="Rnf220"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF220"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF220 isoform 1"
                     /protein_id="NP_001425232.1"
                     /db_xref="GeneID:500532"
                     /db_xref="RGD:1598210"
                     /translation="MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQ
                     PRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPP
                     NLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDSESPHLRFSDADG
                     KEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFD
                     SQAPICPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASI
                     KREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQVCP
                     LCSRPLAGSEQEMSRHVEHCLSKREGSCVAEDDAVDIEHENSNRFEEYEWCGQKRIRA
                     TTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGE
                     AKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDIEK
                     ITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWL
                     RTLGAKKLCPQCNTITAPGDLRRIYL"
     misc_feature    1112..1873
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    1112..1873
                     /gene="Rnf220"
                     /note="E3 ubiquitin-protein ligase RNF220; Region: RNF220;
                     pfam15926"
                     /db_xref="CDD:464946"
     misc_feature    2075..2230
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     misc_feature    2075..2230
                     /gene="Rnf220"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 220 (RNF220) and similar proteins; Region:
                     RING-HC_RNF220; cd16563"
                     /db_xref="CDD:438225"
     exon            1089..1221
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1267
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1369
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1412
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1534
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1667
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1764
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1851
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1907
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1986
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2095
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2170
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..3123
                     /gene="Rnf220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgtgcat gtgtgtgtga gtgtgtgtgc gcgcgcgcgt gtgtgtgcgc ctccgagtcc
       61 ctgggagagt ggaggctcat tcactgatta gagccagcgc tgagaggcag cactgctctt
      121 ctctcacacc aaccgagtct cttgatctgt acatgcaatc ccaggcagct cgcgagcaca
      181 aacccggggc cagccgcctg ctgctgctgc tgctgccgct gccgccgcca ccgccgccgc
      241 tgcccccgcc ggctctgcgc acccgggact tttcatgcac cacactctcc gtcttcttac
      301 ctcggtgtcc tgaaaagtgc gaccgttctc ccctggaatt tccacggtct tcggagggca
      361 tgattcccca gtaataatcc tcgccctgat ccaaggtgca ggttggcctc cctcccaggg
      421 aagactgctt cttgcgtgac acccgccatc gaaagagact ccaatggact tacaccgggc
      481 agccttcaag atggagaact catcctatct tcccaaccct ctggcatccc cggcactgat
      541 ggtcctggcg tccactgccg aggccagcag ggatgcctcc atcccgtgtc agcagccacg
      601 accctttggt gtacctgtct cagtagacaa agacgttcat attcccttca ccaatggctc
      661 ttacaccttt gcctctatgt accaccgtca aggtggggtg ccgggcactt ttgccaatcg
      721 tgatttcccc ccttccttac tacacctcca cccccagttt gcccccccaa atctagattg
      781 caccccaatc agtatgctaa atcacagtgg cgtgggggca ttccgtccct tcgcttccac
      841 ggaggacagg gagagctatc agtcagcctt tacgccagcc aagagactca agaactgtca
      901 cgactcagag tctccccacc tgcgcttctc agatgcagat ggcaaggaat atgactttgg
      961 gacacagctg ccgtccagct cccctggttc acttaaggtt gatgatactg ggaagaagat
     1021 ctttgccgtg tctggcctca tctctgaccg ggaaacctcc tcgagtccag aggatcggaa
     1081 tgacagatgt aagaagaaag cagtagcgtt gtttgacagc caagccccga tctgccccat
     1141 ctgccaagtc ctgctgaggc ccagcgagtt gcaggaacat atggagcaag aactggagca
     1201 gctggcccaa ctgcctgcca gcaaaaattc ccttctgaag gatgccatgg ctccgggcac
     1261 ccccaagtcc ctcctgttgt ctgcttccat caagagggaa ggagactctc caaccgcttc
     1321 cccacactcc tctgccaccg aggacctgca ccactcagac agataccaga ccttcttgcg
     1381 agtgcgagcc aaccggcaaa cccgactgaa tgctcggatt gggaaaatga aacggaggaa
     1441 gcaagatgaa gggcaggtat gtcccctgtg cagccgcccc ctggcaggat cggagcagga
     1501 gatgagtagg catgtggagc attgcctttc taagagggaa ggctcctgcg tggctgagga
     1561 tgacgccgtg gacatcgagc atgagaacag caaccgcttt gaggagtatg agtggtgtgg
     1621 gcagaagcgg atacgggcca ccacgctcct ggaaggtggc ttccgaggct ccggcttcgt
     1681 tatgtgcagt ggtaaagaga atccagacag tgatgctgac ctggatgtgg atggagatga
     1741 cactctggag tatgggaaac cacaatacac agaggctgat gtcatcccat gcacaggaga
     1801 agagcctggt gaagccaagg agagagaggc actccggggc gcagtcctaa atggtggccc
     1861 cccgagcacc cgcatcacac ctgagttctc taaatgggcc agtgatgaga tgccgtccac
     1921 cagcaatggt gaaagcagca agcaggaagc catgcagaag acctgcaaga acagtgacat
     1981 tgagaaaatc accgaagatt cagctgtaac tacctttgag gctctaaagg ctcgggtcag
     2041 ggagcttgaa cggcagctat ctcggggtga ccgatacaaa tgcctcatct gcatggactc
     2101 atactcaatg ccgctgacgt cgatccagtg ttggcatgtg cactgtgaag agtgttggct
     2161 tcggactctg ggtgccaaga agctctgccc tcagtgcaac accatcacag cccctggaga
     2221 cctgcggagg atctacttat gagctagctg tccaggcagg ccctgcctcg agcaaacccc
     2281 tgctccagcc tctgtgacag tgaccgcccc tccccccttg tacatacttg cacacaggtc
     2341 ccccgtgtac atacatgcat atacacaccc aaacacacat agaggactct ggagccagag
     2401 tggaacagcc ctgcctgctt gttccttctg aacttgggga ccatgcctct ttggactctg
     2461 tttccagggt tggcaggaag gtggtttggg aagtatagca ggacgaggct cctgagatcc
     2521 atccccgaga ctgactgaca gacacgcaaa caccagactg aagcacatgt aatatagact
     2581 gtgtatgttt acaatgttgt gtataaatgg gacactttgc cctctaccac cttccccttt
     2641 gggtgtatga ttttcttctt ttataatgac tcctggaagc agtgcccctt cagggctggc
     2701 tgggggctcg gcccaaccac ctcttagggt gcctgcctct tcctctccca tggcatccct
     2761 tcccttcccc atgtgctcag tgttcagtgg tgtatatttc ttctcccaaa cacggggcgt
     2821 gtgccccgag gggtctgatc ctctccttag tcttagctca tggggctcct catgaggagc
     2881 tgggggtagg gtggaatggg accaagcagg aacaggctgc aggctggctg gctgagggtg
     2941 cctggctgcc cagcctgctg ttgagaacca cccctggggt agacactgct cccaggggaa
     3001 gtgctggccc cgcccctgtg tgggccctgt ggtgtgatgc tgtgtctgta tattctatac
     3061 aaaggtactt gtcctttccc tttgtaaact acatttgaca tggattaaaa cagtataaac
     3121 cag
//
LOCUS       NM_001438270            2571 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus FLT3-interacting zinc finger 1 (Fiz1), transcript
            variant 1, mRNA.
ACCESSION   NM_001438270 XM_006228253
VERSION     NM_001438270.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Tsuruyama,T., Imai,Y., Takeuchi,H., Hiratsuka,T., Maruyama,Y.,
            Kanaya,K., Kaszynski,R., Jin,G., Okuno,T., Ozeki,M., Nakamura,T.,
            Takakuwa,T., Manabe,T., Tamaki,K. and Hiai,H.
  TITLE     Dual retrovirus integration tagging: identification of new
            signaling molecules Fiz1 and Hipk2 that are involved in the IL-7
            signaling pathway in B lymphoblastic lymphomas
  JOURNAL   J Leukoc Biol 88 (1), 107-116 (2010)
   PUBMED   20360400
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Wolf,I. and Rohrschneider,L.R.
  TITLE     Fiz1, a novel zinc finger protein interacting with the receptor
            tyrosine kinase Flt3
  JOURNAL   J Biol Chem 274 (30), 21478-21484 (1999)
   PUBMED   10409713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228253.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224110.1, FQ224124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000001.1  77857625-77857678
            55-390              JAXUCZ010000001.1  77859036-77859371
            391-2571            JAXUCZ010000001.1  77862383-77864563
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2571
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="FLT3-interacting zinc finger 1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
     exon            1..54
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    16..18
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="upstream in-frame stop codon"
     exon            55..390
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1581
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Flt3 interacting zinc finger protein 1"
                     /codon_start=1
                     /product="flt3-interacting zinc finger protein 1"
                     /protein_id="NP_001425199.1"
                     /db_xref="GeneID:292584"
                     /db_xref="RGD:1306359"
                     /translation="MDDPSLPVVPAAPGPAPSATAPRVPFHCSECGKSFRYRSDLRRH
                     FARHTALKPHACPRCGKGFKHSFNLANHLRSHTGERPYRCSACPKGFRDSTGLLHHQV
                     VHTGEKPYCCLVCELRFSSRSSLGRHLKRQHRGTLPSPLQPSPGLPPLSSPCSVCCNV
                     GPCSVCGGGGSGGGEGLEGAGATSWGLAEAAAAAAASLPPFACGACARRFDHGRELAA
                     HWAAHTDVKPFKCPRCERDFNAPALLERHKLTHDLQGSSAPPTQVWASGGAPEVAGEG
                     DTAEVGATPPTWDAGLLLSPTGAGVPKLEALLPEDEGAGNAQAPAAAAEASSEDTLYQ
                     CDCGTFFASAPALASHLEAHSGPATYGCGHCGALYAALAALEEHRRASHGKGSGEAAP
                     DGEGEQVAGGPGPGSSSRGKKIFGCSECEKLFRSPRDLERHVLVHTGEKPFPCLECGK
                     FFRHECYLKRHRLLHGTERPFPCHICGKGFITLSNLSRHLKLHRGMD"
     misc_feature    163..231
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    163..231
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    169..231
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    169..231
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    205..282
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    205..282
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    253..315
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    253..315
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(268..270,274..276,280..282,286..291,298..303,
                     310..312,352..354,358..360,370..375,382..387,394..396,
                     436..438,442..444,448..450,454..459,466..471)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(268..270,274..276,280..282,286..291,298..303,
                     310..312,352..354,358..360,370..375,382..387,394..396,
                     436..438,442..444,448..450,454..459,466..471)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    289..360
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    289..360
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    337..399
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    337..399
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    421..477
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    421..477
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    694..756
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    694..756
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    order(709..711,715..717,721..723,727..732,739..744,
                     751..753,793..795,799..807,811..816,826..828,835..837)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    order(709..711,715..717,721..723,727..732,739..744,
                     751..753,793..795,799..807,811..816,826..828,835..837)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275370"
     misc_feature    778..840
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    778..840
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275370"
     misc_feature    1336..1398
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1336..1398
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1351..1353,1357..1359,1363..1365,1369..1374,
                     1381..1386,1393..1395,1435..1437,1441..1443,1453..1458,
                     1465..1470,1477..1479,1519..1521,1525..1527,1531..1533,
                     1537..1542,1549..1554,1561..1563)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1351..1353,1357..1359,1363..1365,1369..1374,
                     1381..1386,1393..1395,1435..1437,1441..1443,1453..1458,
                     1465..1470,1477..1479,1519..1521,1525..1527,1531..1533,
                     1537..1542,1549..1554,1561..1563)
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1372..1449
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1372..1449
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1420..1482
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1420..1482
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1498..1566
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1498..1566
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1504..1566
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1504..1566
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            391..2571
                     /gene="Fiz1"
                     /gene_synonym="RGD1306359"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtggaagt gacgctgacc tcgctgccca aaatgtcggc gcccagaggg aggtagaaag
       61 ccccaagcta ccaccaaacc tcccaccatg gatgacccct cgcttcctgt ggttcctgct
      121 gctccagggc cagcgccatc tgccactgcg cctcgggtcc cctttcactg cagcgaatgt
      181 ggcaagagct tccgttaccg atccgacctg aggcgccatt ttgctcgaca cacagcgctc
      241 aagccccacg catgtcctcg atgcggcaag ggcttcaagc atagcttcaa cttggctaac
      301 cacctgcgct cacacaccgg tgagcgaccc taccgatgtt ccgcctgccc taagggattc
      361 cgagactcca ctggcctgct gcaccaccag gtcgtccaca ctggtgagaa gccctactgc
      421 tgtttggtct gcgagctccg cttctcctct cgctccagcc tgggccgcca tctcaagcgt
      481 cagcaccggg gcacacttcc ctctcccctg cagcctagcc cgggcctgcc tcccttgagc
      541 tccccctgct cagtatgttg caacgttggt ccctgctcag tttgtggagg tggagggtcc
      601 ggtggaggag agggcctgga gggagctgga gcgaccagct ggggactggc agaggctgca
      661 gcagctgcgg cagcttcgct gcccccattt gcatgtggtg cctgtgccag gcgttttgac
      721 catggtcggg agctggcagc ccactgggct gcacacactg atgtgaagcc attcaagtgc
      781 ccgcgttgtg agcgcgactt caatgcacct gcgctgctgg aacgccacaa gctcacacac
      841 gacctgcagg ggagcagtgc acctccaaca caggtttggg cctcgggtgg ggctccagag
      901 gtggcaggag agggtgacac agcggaggtg ggggccaccc caccaacttg ggacgccggg
      961 ctactcctga gccctactgg tgcaggcgtt cccaaactgg aggcactgct tcccgaggat
     1021 gagggcgctg ggaatgccca ggctccggct gcggcagccg aagcatcctc agaagacaca
     1081 ctgtaccaat gcgactgcgg gaccttcttc gcgtctgccc ctgctttagc cagccatcta
     1141 gaggcgcact ctggcccagc cacgtacggc tgtggccatt gcggggcgct gtacgcagca
     1201 ctggccgccc tggaggagca tcggcgtgca agccatggta agggcagcgg ggaggcagcc
     1261 cccgacggtg agggtgagca ggtggctgga gggcccggac ccggttcctc cagccgtggc
     1321 aagaaaatct ttggctgttc tgagtgcgag aagttgttcc gctctcctcg agacctggaa
     1381 aggcatgtgc tggtccatac tggggaaaag ccattcccgt gcctggagtg tggcaagttc
     1441 ttccgccatg agtgctacct caagcgtcac cggctgctgc atggcacaga gcggcccttc
     1501 ccctgccaca tctgtggcaa gggcttcatc acgcttagca acctctccag gcacctgaag
     1561 ctacacaggg gcatggactg aataaccagg acgcccctgc ccactaagtc cagagccaga
     1621 ccatgagatg agccaggccc ctgcctggaa aaatggtgcc gcccagaacc cacataggac
     1681 cacagtgaag catcttttag caaagggatc caagaacata attgttgggg aatttctctc
     1741 tgaaatctac agagactctt gactttgaga cccctggaat gtggcatgtt caaatcagct
     1801 ggcctccgag accggtgacg tagtaatgaa aacgggtctg cactcacatc tctcagcaga
     1861 taacatgtgg gcacctccat ggtgttaacc acccaccact ccctgtgagc catcattcca
     1921 ggtgaccttc attagggaat gggggtgggg caatatcttg aactcctcca ggatcccctc
     1981 cagatgatac ctgtcagcca ctggtggccc cagaaaatga gtataaccga aatctgcctt
     2041 ccccccattt tgcttcctat actgaaagag gaccagggta gatacccccc accttcaatt
     2101 aacccactat cagattaggt ctcccttact gcagaatggt ctgaccctac tggtctcccc
     2161 catcctaaac actagattag actggcccaa agtctccccg ctctttaggt tgtactgacc
     2221 cagatgcaca tactcctatc cacttagaat gggctggtgt ctggaatggt tatggcctaa
     2281 ccccactctc cttagagtaa tagggcagac attcccttat gctgtagagc gcaatccttt
     2341 gaccacagtt gtcccaatcc tgtgacctgg tggaggtggt agacattgag gttttcctcc
     2401 cccttgactt gtagtacttt ggtcttccca tcactacaac ttgactcttt gttccaacgc
     2461 cacaagggga taggggaact tggccagggg tttctcccct gtgagcctca acctgacccc
     2521 tgacccctct ccccaatgtc tctgggactc caataaacct cattcaatca c
//
LOCUS       NM_001014067            2144 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus coiled-coil domain containing 17 (Ccdc17),
            transcript variant 1, mRNA.
ACCESSION   NM_001014067 XM_233417
VERSION     NM_001014067.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2144)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   2  (bases 1 to 2144)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001014067.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1123122.1,
                                           SRR22582419.1266388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               JAXUCZ010000005.1  135289630-135289897
            269-340             JAXUCZ010000005.1  135290021-135290092
            341-506             JAXUCZ010000005.1  135290188-135290353
            507-669             JAXUCZ010000005.1  135290433-135290595
            670-753             JAXUCZ010000005.1  135290679-135290762
            754-872             JAXUCZ010000005.1  135290841-135290959
            873-986             JAXUCZ010000005.1  135291156-135291269
            987-1117            JAXUCZ010000005.1  135291471-135291601
            1118-1209           JAXUCZ010000005.1  135291710-135291801
            1210-1413           JAXUCZ010000005.1  135291946-135292149
            1414-1792           JAXUCZ010000005.1  135292273-135292651
            1793-2144           JAXUCZ010000005.1  135292988-135293339
FEATURES             Location/Qualifiers
     source          1..2144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2144
                     /gene="Ccdc17"
                     /note="coiled-coil domain containing 17"
                     /db_xref="GeneID:500528"
                     /db_xref="RGD:1598211"
     exon            1..268
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    113..115
                     /gene="Ccdc17"
                     /note="upstream in-frame stop codon"
     CDS             146..1927
                     /gene="Ccdc17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 17"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 17 isoform
                     1"
                     /protein_id="NP_001014089.2"
                     /db_xref="GeneID:500528"
                     /db_xref="RGD:1598211"
                     /translation="MADYSGKSGLLPCESCDMVFRSRALLAKHTKRFCIGGLTPEIMA
                     QEQRRSDQEATKSSLKRLTEETELLRLSLQKIGPWATDTSQTAGSPEERLRDLQGTRA
                     RRVEETEAQSRALKQRGEELKRRLHSVAGPKGGLPRPIVLERELRELREEASRTRGAL
                     QTLGARVQALQPQPAHQQDAKRVVEFCCLPLRYNPETLAEEIRVLREVYVRGGGRDPE
                     VLDKILQLQVEASALELRRSQNRKEKASAASEEALMVEAENRILEAEILALQKQKVLS
                     LSPWGSRDLWRHLSRRSDNSLLPPPVAPPMPPVTSSTKVQDFHGTSKAIINGTMTRNL
                     GLDLHFLPASNVLGPAPYDPGAGLVIFYDFLRGLEASWIWVQLMTSLARDGQDTGGAT
                     ALPPALCLPPPSASGPIGNCAILASRQPVPRLPPSPLLSLICKLQAWQGVTWTPQPKA
                     WASLLLFDQSLRVLSGRWRLPLRVPPTTSLSFAQMNEMPQVSVEGRDWLHPKIPMEYH
                     FLCQAGQAELFLRLVNARDTDAQTLAEINPASAHEYQYPPMMSSSSSLESSFFTHSSG
                     IADPPPPTEETFVSVEDKDEHLSPHQF"
     misc_feature    <257..>958
                     /gene="Ccdc17"
                     /note="DNA double-strand break repair ATPase Rad50;
                     Region: PRK03918"
                     /db_xref="CDD:235175"
     misc_feature    <257..>958
                     /gene="Ccdc17"
                     /note="DNA double-strand break repair ATPase Rad50;
                     Region: PRK03918"
                     /db_xref="CDD:235175"
     exon            269..340
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            341..506
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            507..669
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            670..753
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            754..872
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            873..986
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1117
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1209
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1413
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1792
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2144
                     /gene="Ccdc17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacataaac ataaatttga aggacttgga gatgtagcag agttggtcta ttctttgtct
       61 ctttgctctc ttttctttcc agtctacctt ttccctttta ccacatcctc tgtaggacgc
      121 tggtgtcttt aacagattcc atcccatggc cgattactct gggaagtcag gacttttgcc
      181 ctgtgagtcc tgtgatatgg ttttccgctc cagagctttg ttggccaaac acaccaagcg
      241 attctgcatt ggcggactga ctccggagat tatggcacaa gaacagaggc gttcagatca
      301 ggaggccacc aaatcttctc taaagagact gacagaggag acggagttgc tgagactgtc
      361 cctacagaaa ataggtccct gggcgactga cacttcccag actgcaggga gccctgagga
      421 gaggctgcga gacttgcagg gaacacgagc cagacgcgtg gaggaaactg aagcgcaaag
      481 ccgagcgctg aagcaacgcg gcgaagaatt aaaacggcgc ctccacagcg tagcgggacc
      541 caagggagga ttaccccgcc caatagtctt ggagcgcgaa ctcagagaac tcagggaaga
      601 ggccagccgg acacggggag cgctgcaaac gttaggagcg cgtgttcagg cgctccagcc
      661 tcagcccgcc caccagcagg acgccaaaag ggtagtggaa ttctgttgcc tgcccctacg
      721 gtacaacccg gaaacgcttg ctgaagagat ccgggtgcta cgtgaggtct acgtgcgcgg
      781 tggaggccgg gacccagaag ttctggacaa aatattacaa ctgcaagtgg aggcgtcagc
      841 actggaattg cggcggtcgc aaaaccgcaa ggaaaaagca agtgccgcct ctgaggaggc
      901 tctaatggtg gaagccgaaa acaggatcct ggaggcagaa attctggcct tgcagaagca
      961 gaaagtcctg agtctgtcgc cctggggttc cagggatctc tggcgacact tgagtagaag
     1021 gagtgataac tccctcctcc ctccaccagt tgcaccccca atgccaccag ttacaagttc
     1081 cacaaaagtc caggacttcc acggcacttc aaaggctata attaatggaa ccatgacaag
     1141 aaacttgggt ctggatctcc acttcctacc agcatcgaat gttctaggtc ctgcacccta
     1201 tgatcctggg gctggccttg tcattttcta tgacttcctg cggggccttg aggcttcttg
     1261 gatttgggtg cagctaatga caagcttggc ccgagatgga caggatacag gaggggccac
     1321 agcactacct ccagcacttt gcttgccgcc accttcagct tctggaccta taggcaactg
     1381 tgctatcctc gcaagcaggc aacctgtgcc gaggctgcct ccatcaccac tgctatcttt
     1441 gatctgcaaa ctacaggcct ggcagggtgt tacatggaca ccacaaccaa aggcttgggc
     1501 ctcactactg ctatttgacc aaagtctgag ggtgcttagt ggccgttggc gcctcccact
     1561 tcgggtccct cctaccacca gcctcagctt tgcccagatg aatgagatgc cccaggtaag
     1621 tgtagagggt agagactggt tgcaccccaa gattccaatg gagtaccact tcctctgtca
     1681 ggccggccaa gctgagctct ttctgaggct ggtaaacgca agagatacag atgcccagac
     1741 attggcagag atcaatccag caagtgccca tgagtaccag tacccaccaa tgatgtccag
     1801 ttcatcttcc ctggaatcca gtttcttcac ccacagttct ggcattgctg accctccacc
     1861 tcccacagaa gagacttttg tcagtgtcga ggataaagat gagcacttga gtcctcacca
     1921 gttttgaagg aaacactaat ttctagacct gcagctttta aaatggggtc ttacagcagc
     1981 agcaaacatt tgatccttaa atactgggtg gctacaaaga acactaaacc tgcttttctt
     2041 aaactagcca actttatata aaaagccaac taattttctt ctgcatttac tttcctttta
     2101 taaagcagat ccaggaataa atgacctcaa aatatttagt caaa
//
LOCUS       NM_001438326            1381 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus StAR-related lipid transfer domain containing 10
            (Stard10), transcript variant 4, mRNA.
ACCESSION   NM_001438326 XM_063285179
VERSION     NM_001438326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Ito,M., Yamanashi,Y., Toyoda,Y., Izumi-Nakaseko,H., Oda,S.,
            Sugiyama,A., Kuroda,M., Suzuki,H., Takada,T. and Adachi-Akahane,S.
  TITLE     Disruption of Stard10 gene alters the PPARalpha-mediated bile acid
            homeostasis
  JOURNAL   Biochim Biophys Acta 1831 (2), 459-468 (2013)
   PUBMED   23200860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_063285179.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.4558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000001.1  165130437-165130560
            125-227             JAXUCZ010000001.1  165134533-165134635
            228-547             JAXUCZ010000001.1  165134991-165135310
            548-695             JAXUCZ010000001.1  165155405-165155552
            696-799             JAXUCZ010000001.1  165156043-165156146
            800-917             JAXUCZ010000001.1  165156758-165156875
            918-970             JAXUCZ010000001.1  165158462-165158514
            971-1381            JAXUCZ010000001.1  165158724-165159134
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1381
                     /gene="Stard10"
                     /note="StAR-related lipid transfer domain containing 10"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
     exon            1..124
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="Stard10"
                     /note="upstream in-frame stop codon"
     CDS             122..1213
                     /gene="Stard10"
                     /note="isoform 2 is encoded by transcript variant 4; START
                     domain containing 10; PCTP-like protein; StAR-related
                     lipid transfer (START) domain containing 10; START
                     domain-containing protein 10"
                     /codon_start=1
                     /product="START domain-containing protein 10 isoform 2"
                     /protein_id="NP_001425255.1"
                     /db_xref="GeneID:293150"
                     /db_xref="RGD:1306548"
                     /translation="MGPRAAPGRPGSGGSGAGGRARTPAPARPGREARTGPRKVASAS
                     AAAPTLSEPPRRTQESRTRTRAPGLPTLSMEKPAASTEPQGPRPALGRESVQVPDDQD
                     FRSFRSECEAEVGWNLTYSKAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLH
                     DIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYII
                     MNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKS
                     SQFLAPKAMKKMYKACIKYPEWKQKHQPHFKPWLHPEQSPLPSLALSELSVQHADSLE
                     NIDESAVTESREERAGGAGEGSDDDTSLT"
     misc_feature    395..1063
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    395..1063
                     /gene="Stard10"
                     /note="Lipid-binding START domain of mammalian STARD10 and
                     related proteins; Region: START_STARD10-like; cd08871"
                     /db_xref="CDD:176880"
     misc_feature    order(476..481,500..502,542..544,548..550,584..586,
                     596..598,614..616,623..628,632..637,692..694,698..709,
                     713..715,722..724,728..730,734..736,779..781,830..832,
                     836..847,851..853,887..889,893..895,899..901,905..907,
                     911..913,917..919,938..940,944..952,956..964,971..976,
                     983..985)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     misc_feature    order(476..481,500..502,542..544,548..550,584..586,
                     596..598,614..616,623..628,632..637,692..694,698..709,
                     713..715,722..724,728..730,734..736,779..781,830..832,
                     836..847,851..853,887..889,893..895,899..901,905..907,
                     911..913,917..919,938..940,944..952,956..964,971..976,
                     983..985)
                     /gene="Stard10"
                     /note="putative lipid binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176880"
     exon            125..227
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            228..547
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            548..695
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            696..799
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            800..917
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            918..970
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1381
                     /gene="Stard10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatttact ccatccttag cagcagacag ggttacccca ggaggaaggt ggggaaaagg
       61 ggcccgtggg ggtaatttat catccaaaga cctccgtctg tctgtctgtc tgtctgtcta
      121 gatgggcccc cgcgcggccc ccggtcgccc gggcagcgga ggcagcggcg ccggcggaag
      181 agctcgcacc ccggccccgg cccgccccgg cagagaagcc cgtacaggtc ccaggaaggt
      241 ggcgtcagca tctgcagccg cgccgacgtt gtctgagcct ccgcggagga cccaggagag
      301 tcggactagg accagggccc cgggcctccc cacgctctct atggaaaagc cagctgcttc
      361 aacagaaccc caagggcctc ggcccgcttt gggccgtgaa agtgtccagg tgcccgatga
      421 ccaggacttc cgcagttttc ggtcagagtg tgaggccgag gtgggctgga acctgaccta
      481 cagcaaggcc ggtgtgtctg tgtgggtgca ggctgtggag atggatcgaa ctctgcacaa
      541 gatcaagtgc aggatggaat gctgtgacgt accagctgag acgctctacg atgtcctgca
      601 cgacatagaa taccgaaaga agtgggacag taatgtcatc gagacattcg acatcgctcg
      661 actgactgtc aacgctgacg taggatatta ctcctggagg tgtcccaagc ccctgaagaa
      721 ccgtgatgtc atcaccctcc gctcctggct ccccatgggc gctgattaca tcattatgaa
      781 ctactcagtg aaacacccta aatacccacc tcggaaagac ttggtccgag ctgtgtccat
      841 ccagacgggc tacctcatcc agagcacggg gcccaagagc tgtgtcatca cctacctggc
      901 ccaagtggac cccaaaggct ccttacccaa gtgggtggtg aataagtcat ctcagttcct
      961 ggcccccaag gccatgaaga agatgtacaa ggcctgcatc aagtaccctg agtggaagca
     1021 gaaacaccag ccacatttca agccatggct gcacccggag cagagcccgt tacccagcct
     1081 ggcgctgtca gagctgtcgg tgcaacacgc agactcactg gagaacatcg acgagagcgc
     1141 cgtgacagag agccgggagg agcgggcggg tggagcagga gagggcagcg atgacgacac
     1201 ctcgctcacc tgagaaccgc ctctcttcaa ggaccaagac aggactgggg tggaaccctg
     1261 gggcactgag ccttctgcac ttcctccctt cccccacctg ccttttgggg gcactgggct
     1321 cctgctcagg tggctgcggc atggctggac atggccccaa taaatgaacc acacagcccc
     1381 a
//
LOCUS       NM_001438277            3074 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), transcript
            variant 1, mRNA.
ACCESSION   NM_001438277 XM_006228216
VERSION     NM_001438277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228216.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168158.1, SRR26360176.2407213.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000001.1  79143873-79144074   c
            203-381             JAXUCZ010000001.1  79140675-79140853   c
            382-493             JAXUCZ010000001.1  79138630-79138741   c
            494-714             JAXUCZ010000001.1  79137661-79137881   c
            715-810             JAXUCZ010000001.1  79135186-79135281   c
            811-883             JAXUCZ010000001.1  79134012-79134084   c
            884-959             JAXUCZ010000001.1  79133654-79133729   c
            960-1015            JAXUCZ010000001.1  79132689-79132744   c
            1016-1108           JAXUCZ010000001.1  79132406-79132498   c
            1109-1201           JAXUCZ010000001.1  79131894-79131986   c
            1202-1344           JAXUCZ010000001.1  79128304-79128446   c
            1345-1390           JAXUCZ010000001.1  79128125-79128170   c
            1391-1464           JAXUCZ010000001.1  79127788-79127861   c
            1465-3074           JAXUCZ010000001.1  79125564-79127173   c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3074
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..202
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1429
                     /gene="Ttyh1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1 isoform 1"
                     /protein_id="NP_001425206.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
                     "
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    101..1399
                     /gene="Ttyh1"
                     /note="Region: Tweety; pfam04906"
                     /db_xref="CDD:461475"
     misc_feature    206..268
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    341..403
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    464..466
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    569..571
                     /gene="Ttyh1"
                     /note="Essential for the formation of the channel-pore.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); other site"
     misc_feature    719..781
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    797..859
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    926..928
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    1139..1141
                     /gene="Ttyh1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); glycosylation site"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    order(1187..1189,1196..1198)
                     /gene="Ttyh1"
                     /note="putative pore region [active]"
                     /db_xref="CDD:143653"
     misc_feature    1247..1309
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     transmembrane region"
     misc_feature    1358..1426
                     /gene="Ttyh1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C5X8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1394..1396
                     /gene="Ttyh1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9D3A9; propagated from
                     UniProtKB/Swiss-Prot (P0C5X8.1); phosphorylation site"
     exon            203..381
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..493
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..714
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..810
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..959
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1015
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1344
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1390
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1464
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3074
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccggct ccgcccgcgc cccgcacagc accgaggctc ccggcccggt ccgccccgct
       61 gcccctcccc ggggccatgg gggcaccccc gggctaccga ccctctgcct gggtgcatct
      121 cctccaccag ctgccccgtg ccgacttcca gctccgcccg gtgcccagcg gctttgctcc
      181 ccgcgaccaa gagtaccagc aggccctgct gctggtggca gccttggctg ggctgggttt
      241 gggcctgagc ctcatcttca tcgctgtcta cctcatccgc ttctgctgct gcaggcctcc
      301 agaaccccct ggggccaaga gtcccccacc cggaggaggc tgtgtcacct ggagctgcat
      361 tgctgccctt ctcgtgggct gtgcaggcat tggcattggt ttctatggta acagcgagac
      421 cagtgatggg gtgtcccagc tcagctcagc actgcagcat gccaaccaca cgctcagcac
      481 cattgatgac ttggtgctgg aaacggtaga gaggctgggt gaggctgtga ggacagagct
      541 gaccaccctg gaggaagtgt tgtcagaacg cgtggagctg gtggctgcca cccggggagc
      601 cagaaggcag gctgaggcag cagctcagca cctgcaaggc ctagccttct ggcagggagt
      661 gtccctgagc ccagtacagg tggctgagga tgtgactttc gtggaggagt acaggtggct
      721 ggcctatgtc ctcctgctgc tcttggtgct tctggtttgt ctcttcaccc tcctgggcct
      781 ggccaagcag agcaagtggc tggtggttgt gatgaccgcc atgagtctcc tggtgcttgt
      841 cctgagctgg ggttctatgg gcctagaggc tgccacagct gtgggtctca gtgacttctg
      901 ctccaaccca gacacctatg tgctgaactt gacccaggag gagacaggaa tcagttcaga
      961 catcctcaac tattatttcc tgtgcaacca ggcggtctcc aaccccttcc aacagaggct
     1021 gactctgtcc cagcgtgctc tagccagcat ccactctcag ctgcaaggcc tggagcggga
     1081 agctagccct caatttcctg ctgcacagaa gcccttgtta tccttggagg agacgctgaa
     1141 tgtgacagaa agaagcttcc accagttggt ggcactgctg cactgccgca gtctgcacaa
     1201 ggactatggc tcagcactcc gaggcctgtg tgaagatgcc ctagagggcc tgctgttcct
     1261 gatgctcttt tctctcctgt ctgccggggc cctagccacc actctttgca gcctgccccg
     1321 tgcctgggct ctcttcccac ccagtgatga ctacgatgac acagacgatg acgacccttt
     1381 caaccctcag gaatccaagc gctttgtgca gtggcagtct tccatctgag cccccctgcc
     1441 agtgtggcct gcctctcctc tttggctcag cactgctttg cttctgaaag tcacgtgtga
     1501 atcctgacaa gggggaagaa gcagatccca gaagagagta agcctaacac taaattaaac
     1561 atgcgtgcat ccacaggaag agtcaacctt ccagtcacgt ggaatgttca aagcctgctg
     1621 ggattaggaa cggtgtggaa tcgaatcaac ttgcttccta gcagctcata tcctacacaa
     1681 gaacgtcaga aaactaacgc ttgtttcagg atagggacag aaatcttcag agagaagtag
     1741 aatatttgct cgtaatgcta ccacggtgat gtaaagggag aaggtttaag gaagataata
     1801 taaatccaga caggaaaaga tgaggcaatc atcaagttgt caagtaaaaa caaacatggc
     1861 agagtcaaaa gggaaattta ttgtctgggg aacaattcct atgtagttct tatttgttaa
     1921 aaaaaaaaaa agtagcacac atgacaaagg aaaacattgt tgttaataga taaacataat
     1981 tcaaaaagct tctattatct aacaaaaaac agaccaactc aatttagtaa taagtaactg
     2041 agatgaacgt acaaggaaac aaaatcccca agacaaagga taaaactggg gatttttggt
     2101 tttcattttg gtttttggtt ttttgagaca ggctttcttt gtaatagacc tgggtgtcct
     2161 ggaactcttt gtagaccagg ctggccttga cctcacagag aacagcctgc ctctgcctcc
     2221 ctagtactga gattaaagca tgtatcacca tatcaccagc taaaatgttc aagttctaat
     2281 gattagcaaa cacgatgtgc tactttcccc tttctagtac ctacttgttg tggactttaa
     2341 agtggggtgt tggctggtgc tagtctggag gctcagggaa aaagttctct gaatatgctg
     2401 ctcagaggcg gtgaatcacc agctatgtga aaataataat taaaacaaac aaacaaaaca
     2461 aaaccctgct cacatctctt aacctggtaa tcctttgggg cacaagcttc cagtaagaga
     2521 tgaacaggca acccttggct cagttaaacc ctggagacag aaatgttcac aaaaggaaga
     2581 acagtaatgt agagcaggat cctcaagttc acagtggcaa gtggggtaca gaggcaccag
     2641 gggtatccct ggccctgtgc tggttggaag cctctgggtc ctagacctgg caccactatg
     2701 ttaatgtgga caagttatct gactggttga acctcagttg aatggtgaag caaatgggta
     2761 tcataaatcc agaaaacagc tcttgacatg ataggtaata agcaggataa atgcagcatg
     2821 atgttctggg ttacattctg gtgcacagaa aacattagta ggaaaagtac ccacttctaa
     2881 agtctgcggc ttagttcaga gtattaaagc aatgtcaatt tcttactttt aacaaataaa
     2941 ccatggtgaa ttcgaggtgt ggaatctagc aataggggaa actgggcagt gtgctcaatt
     3001 cctgtattac ctttgcaatt tttatttctg taaacttaaa tttattctaa aataaaagtt
     3061 cattataaaa agga
//
LOCUS       NM_001438262            2242 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus thyroid hormone receptor interactor 13 (Trip13),
            transcript variant 1, mRNA.
ACCESSION   NM_001438262 XM_008758681
VERSION     NM_001438262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2242)
  AUTHORS   Yost,S., de Wolf,B., Hanks,S., Zachariou,A., Marcozzi,C.,
            Clarke,M., de Voer,R., Etemad,B., Uijttewaal,E., Ramsay,E.,
            Wylie,H., Elliott,A., Picton,S., Smith,A., Smithson,S., Seal,S.,
            Ruark,E., Houge,G., Pines,J., Kops,G.J.P.L. and Rahman,N.
  TITLE     Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome
            missegregation
  JOURNAL   Nat Genet 49 (7), 1148-1151 (2017)
   PUBMED   28553959
REFERENCE   2  (bases 1 to 2242)
  AUTHORS   Roig,I., Dowdle,J.A., Toth,A., de Rooij,D.G., Jasin,M. and
            Keeney,S.
  TITLE     Mouse TRIP13/PCH2 is required for recombination and normal
            higher-order chromosome structure during meiosis
  JOURNAL   PLoS Genet 6 (8), e1001062 (2010)
   PUBMED   20711356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2242)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   4  (bases 1 to 2242)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   5  (bases 1 to 2242)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_008758681.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.424.1, SRR26643299.401.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000001.1  31185684-31185902
            220-385             JAXUCZ010000001.1  31186876-31187041
            386-515             JAXUCZ010000001.1  31189173-31189302
            516-571             JAXUCZ010000001.1  31192046-31192101
            572-662             JAXUCZ010000001.1  31192635-31192725
            663-735             JAXUCZ010000001.1  31194352-31194424
            736-799             JAXUCZ010000001.1  31196608-31196671
            800-886             JAXUCZ010000001.1  31197452-31197538
            887-993             JAXUCZ010000001.1  31197790-31197896
            994-1147            JAXUCZ010000001.1  31199288-31199441
            1148-1260           JAXUCZ010000001.1  31201634-31201746
            1261-1330           JAXUCZ010000001.1  31202581-31202650
            1331-2242           JAXUCZ010000001.1  31203812-31204723
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2242
                     /gene="Trip13"
                     /note="thyroid hormone receptor interactor 13"
                     /db_xref="GeneID:292206"
                     /db_xref="RGD:1308516"
     exon            1..219
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1426
                     /gene="Trip13"
                     /note="thyroid receptor-interacting protein 13; TRIP-13;
                     TR-interacting protein 13"
                     /codon_start=1
                     /product="pachytene checkpoint protein 2 homolog"
                     /protein_id="NP_001425191.1"
                     /db_xref="GeneID:292206"
                     /db_xref="RGD:1308516"
                     /translation="MDDAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKQSVYR
                     LLKRHNIVFGDYVWTEFDEPFLTRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQL
                     NEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFS
                     DKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLF
                     SKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRV
                     VNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSC
                     LEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLP
                     FLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAHV"
     misc_feature    128..130
                     /gene="Trip13"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q15645; propagated from
                     UniProtKB/Swiss-Prot (Q5XHZ9.1); acetylation site"
     misc_feature    227..>742
                     /gene="Trip13"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; Region: McrB; COG1401"
                     /db_xref="CDD:441011"
     misc_feature    227..>742
                     /gene="Trip13"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; Region: McrB; COG1401"
                     /db_xref="CDD:441011"
     misc_feature    488..1084
                     /gene="Trip13"
                     /note="ATPase domain of Pachytene checkpoint 2 (Pch2) and
                     similar ATPase domains; Region: RecA-like_Pch2-like;
                     cd19508"
                     /db_xref="CDD:410916"
     misc_feature    488..1084
                     /gene="Trip13"
                     /note="ATPase domain of Pachytene checkpoint 2 (Pch2) and
                     similar ATPase domains; Region: RecA-like_Pch2-like;
                     cd19508"
                     /db_xref="CDD:410916"
     misc_feature    order(527..529,578..583,590..595,611..622,626..640,
                     770..772,776..781,797..799,1058..1060)
                     /gene="Trip13"
                     /note="hexamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410916"
     misc_feature    order(527..529,578..583,590..595,611..622,626..640,
                     770..772,776..781,797..799,1058..1060)
                     /gene="Trip13"
                     /note="hexamer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:410916"
     misc_feature    order(665..667,677..685,758..760,764..769,881..886)
                     /gene="Trip13"
                     /note="ATP binding site [active]"
                     /db_xref="CDD:410916"
     misc_feature    order(665..667,677..685,758..760,764..769,881..886)
                     /gene="Trip13"
                     /note="ATP binding site [active]"
                     /db_xref="CDD:410916"
     exon            220..385
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            386..515
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            516..571
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            572..662
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            663..735
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            736..799
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            800..886
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            887..993
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1147
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1260
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1330
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..2242
                     /gene="Trip13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatttgtcc gggactcggc cagggtggat cttcgtacag ctgagaagac tgtcccacag
       61 ggcgccgaga ggcgaccgcg acctcattct ggctggccgc atttcctcgg ctcccggctg
      121 cggcgccatg gacgacgcgg tgggcgacct gaagcaagcg cttccgtgtg ttgccgagtc
      181 gcccgcggtc catgtggagg ttttgcagcg cagcggaagc actgcaaaaa aagaagatat
      241 aaagcagagc gtttacaggc tgctcaagag gcataacatt gtgtttggag attacgtgtg
      301 gactgagttt gatgagcctt ttctaactag aaatgttcag tcggtatcta ttgttgacac
      361 agaattaaag gctaaagacc ctcagcccat tgatctgagt gcatgcacca ttgcacttca
      421 catcttccag ctgaatgaag aaggccccag cagtgaaaat ttggatgaag aaacagaaaa
      481 tataattgca gcaagtcact gggttttgcc tgcagctgaa tttcatgggc tttgggatag
      541 cctcgtgtat gatgtggagg tcaaatcaca tctccttgac tatgtgatga ccaccttact
      601 attctcagac aagaatgtgg acagcaacct tatcacctgg aaccgggtgg tactgctgca
      661 cggtcctccg ggtactggaa agacatccct ttgtaaggca ttagcccaga aactgaccat
      721 cagactgtca agcaggtacc ggtatggcca gttaattgaa ataaacagcc acagcctatt
      781 ttctaagtgg ttttcagaaa gtggcaagtt ggtaactaag atgttccaga agattcagga
      841 cttgattgat gataaagaag ctttggtgtt tgttctgatt gatgaggtgg agagtcttac
      901 agctgctcga aatgcttgca gggcaggcgc agagccatca gatgctatcc gtgtagtcaa
      961 tgctgtgttg actcagattg atcagattaa aaggcattcc aatgtggtga ttctgaccac
     1021 ttccaacatc actgagaaga ttgatgtggc ctttgtggat agagctgaca tcaaacaata
     1081 tattggcccc ccctctgcag cagccatctt caaaatctac ctgtcttgtt tagaagaact
     1141 gatgaagtgc cagatcatat atccccgtca gcagctgttg acccttcgag agctggaaat
     1201 gattggcttc attgaaaata atgtgtcgaa gttgagcctc cttttgagtg aaatttcaag
     1261 gaagagtgag ggcctcagcg gccgggtctt gaggaaactt cctttcctgg ctcatgcgct
     1321 gtatatccag gctcccagcg tcaccatcga gggtttcctc caggccctgt ctctggcagt
     1381 ggacaaacag tttgaggaga aaaagaaact ctcagctcat gtttgatccc agacatccat
     1441 atctgtggtt ttcaatggac aggtaggagg tgataccgtc tacctcacag tgtgcatcag
     1501 aaatgactaa accatgtagg tctgcaggcc aggccagaca gatgggtgta cagactttgt
     1561 caaaaggact gtttgtgtta ttttacaatg cacattgaaa ggcaaactgc ctgtcttttt
     1621 cactgttttt aaaagacaat tgattccagt ctgtttacat ctatgtaaag ccccatcctg
     1681 actctagcct gtcagacaca agatgttaaa atttgtttaa aataaaggga gatcaaaaca
     1741 gctttcctag agcaagagga gtgctgaata atgcagttac ggcactgaaa gatggactct
     1801 tgctccggct agaagggagc ggctacttcc tggcaggagt ctgcttcggt tagcaccgga
     1861 tgctgtggaa tgggtgagaa agacgtgctc ctgtgataca gaaactgaga aaaggattgc
     1921 agataagaag ataaagactt ctgtgatagc gatcagatgt tgtgttcaga ggagcagtac
     1981 gtactttcta tggtcaagag aatcaggcaa tgtgtgtttt gtttttccag taattttact
     2041 catatttcaa gtgaaaattc atgttgtcaa atataaaata agtcaatgtg tgttgcacct
     2101 cacagaatac catgttttac ttcatcttct gctaaaagtt tagcattaat actttgtacg
     2161 tgaatacact tttaaatgga atgctgcctt tgtcatagaa ttttttgtaa tattaaactt
     2221 gttttcagaa tgcgcttatt cc
//
LOCUS       NM_001106880            4185 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus phospholipase C-like 2 (Plcl2), mRNA.
ACCESSION   NM_001106880 XM_001056257 XM_217326
VERSION     NM_001106880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Oue,K., Zhang,J., Harada-Hada,K., Asano,S., Yamawaki,Y.,
            Hayashiuchi,M., Furusho,H., Takata,T., Irifune,M., Hirata,M. and
            Kanematsu,T.
  TITLE     Phospholipase C-related Catalytically Inactive Protein Is a New
            Modulator of Thermogenesis Promoted by beta-Adrenergic Receptors in
            Brown Adipocytes
  JOURNAL   J Biol Chem 291 (8), 4185-4196 (2016)
   PUBMED   26706316
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Kanematsu,T., Yasunaga,A., Mizoguchi,Y., Kuratani,A., Kittler,J.T.,
            Jovanovic,J.N., Takenaka,K., Nakayama,K.I., Fukami,K., Takenawa,T.,
            Moss,S.J., Nabekura,J. and Hirata,M.
  TITLE     Modulation of GABA(A) receptor phosphorylation and membrane
            trafficking by phospholipase C-related inactive protein/protein
            phosphatase 1 and 2A signaling complex underlying brain-derived
            neurotrophic factor-dependent regulation of GABAergic inhibition
  JOURNAL   J Biol Chem 281 (31), 22180-22189 (2006)
   PUBMED   16754670
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Takenaka,K., Fukami,K., Otsuki,M., Nakamura,Y., Kataoka,Y.,
            Wada,M., Tsuji,K., Nishikawa,S., Yoshida,N. and Takenawa,T.
  TITLE     Role of phospholipase C-L2, a novel phospholipase C-like protein
            that lacks lipase activity, in B-cell receptor signaling
  JOURNAL   Mol Cell Biol 23 (20), 7329-7338 (2003)
   PUBMED   14517301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 7, 2025 this sequence version replaced NM_001106880.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.214432.1,
                                           SRR26643298.47663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               JAXUCZ010000009.1  3529813-3530369
            558-3044            JAXUCZ010000009.1  3632730-3635216
            3045-3248           JAXUCZ010000009.1  3637517-3637720
            3249-3324           JAXUCZ010000009.1  3678453-3678528
            3325-3434           JAXUCZ010000009.1  3695114-3695223
            3435-4185           JAXUCZ010000009.1  3712956-3713706
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..4185
                     /gene="Plcl2"
                     /note="phospholipase C-like 2"
                     /db_xref="GeneID:301173"
                     /db_xref="RGD:1305941"
     exon            1..557
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    42..44
                     /gene="Plcl2"
                     /note="upstream in-frame stop codon"
     CDS             228..3614
                     /gene="Plcl2"
                     /EC_number="3.1.4.11"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 2"
                     /protein_id="NP_001100350.2"
                     /db_xref="GeneID:301173"
                     /db_xref="RGD:1305941"
                     /translation="MAECGRGAAGGALPTSPGPALGAKGALKAGAGEGGGSGGGGRLG
                     HGRARYDSGGVSNGDCSLGVSGDEARASPARGPRGVALARTPSPAAGPVPRDSKPGGL
                     PRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIY
                     HRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCA
                     FSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTCWVSQM
                     FSEIDVDDLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKTGTEITKEEFVE
                     VFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPS
                     KEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQ
                     FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYA
                     FFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKI
                     LIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKDLSELVS
                     ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMR
                     IDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSF
                     FSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ
                     RTKTVNQNGDAPMFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTG
                     YRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWI
                     KTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPD
                     NTPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQ
                     KAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQ
                     IHYAAVSCGLNKPGTENSEAQKPRRSLEVIPEKTSDENGD"
     misc_feature    657..983
                     /gene="Plcl2"
                     /note="Phospholipase C-eta (PLC-eta) pleckstrin homology
                     (PH) domain; Region: PH_PLC_eta; cd13364"
                     /db_xref="CDD:270170"
     misc_feature    657..983
                     /gene="Plcl2"
                     /note="Phospholipase C-eta (PLC-eta) pleckstrin homology
                     (PH) domain; Region: PH_PLC_eta; cd13364"
                     /db_xref="CDD:270170"
     misc_feature    order(672..674,678..680,708..710,759..761,930..932)
                     /gene="Plcl2"
                     /note="putative Rac1 binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:270170"
     misc_feature    order(672..674,678..680,708..710,759..761,930..932)
                     /gene="Plcl2"
                     /note="putative Rac1 binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:270170"
     misc_feature    order(681..683,687..689,699..701,705..707,711..713,
                     756..761)
                     /gene="Plcl2"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270170"
     misc_feature    order(681..683,687..689,699..701,705..707,711..713,
                     756..761)
                     /gene="Plcl2"
                     /note="putative phosphoinositide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:270170"
     misc_feature    1041..1472
                     /gene="Plcl2"
                     /note="EF-hand motif found in phospholipase C-related but
                     catalytically inactive protein 2 (PRIP-2); Region:
                     EFh_PRIP2; cd16223"
                     /db_xref="CDD:320053"
     misc_feature    1041..1472
                     /gene="Plcl2"
                     /note="EF-hand motif found in phospholipase C-related but
                     catalytically inactive protein 2 (PRIP-2); Region:
                     EFh_PRIP2; cd16223"
                     /db_xref="CDD:320053"
     misc_feature    1041..1130
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1041..1130
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1149..1247
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1149..1247
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1257..1343
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1257..1343
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1368..1472
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1368..1472
                     /gene="Plcl2"
                     /note="EF-hand motif [structural motif]; Region: EF-hand
                     motif"
                     /db_xref="CDD:320053"
     misc_feature    1503..2393
                     /gene="Plcl2"
                     /note="Catalytic domain of metazoan phospholipase C
                     related, but catalytically inactive protein; Region:
                     PI-PLCc_PRIP_metazoa; cd08597"
                     /db_xref="CDD:176539"
     misc_feature    1503..2393
                     /gene="Plcl2"
                     /note="Catalytic domain of metazoan phospholipase C
                     related, but catalytically inactive protein; Region:
                     PI-PLCc_PRIP_metazoa; cd08597"
                     /db_xref="CDD:176539"
     misc_feature    2487..2873
                     /gene="Plcl2"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); Region: C2_PLC_like; cd00275"
                     /db_xref="CDD:175974"
     misc_feature    2487..2873
                     /gene="Plcl2"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); Region: C2_PLC_like; cd00275"
                     /db_xref="CDD:175974"
     misc_feature    order(2568..2570,2640..2642,2727..2729,2733..2735,
                     2748..2750,2754..2756)
                     /gene="Plcl2"
                     /note="Ca2+ binding pocket [ion binding]; other site"
                     /db_xref="CDD:175974"
     misc_feature    order(2568..2570,2640..2642,2727..2729,2733..2735,
                     2748..2750,2754..2756)
                     /gene="Plcl2"
                     /note="Ca2+ binding pocket [ion binding]; other site"
                     /db_xref="CDD:175974"
     exon            558..3044
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3248
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3324
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3434
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..4185
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccagagg tgactccgcc tgcacgacgt cctccgtgcc gtaggcgagc tcgcctcacg
       61 cgccacatcc cgatcaaaaa gagaaagaaa aaaaaaaaaa aagaaaagaa aaagcggaag
      121 aagcggccga ggcggcggcg gcgaggagga ggggccgcgc gcggcggccg gaggcggcgg
      181 ccgggacgcg gggacgcggc tttgtgcagg cgggtcgtgg ggcgcccatg gcggagtgtg
      241 gccggggcgc cgcaggcggg gccctgccca cctccccggg cccggccctc ggcgccaagg
      301 gcgccctgaa agcgggagcc ggggaaggcg gcggtagcgg cgggggaggt cgcctcggcc
      361 acgggcgggc gcgctatgac agcggcgggg tttccaacgg agactgcagc ctcggagtgt
      421 ccggggacga agcccgggcc agccctgcca ggggacctcg aggcgtggcg ctcgcgcgga
      481 cccctagccc ggctgcgggt ccggtcccca gggacagcaa gccgggcggc ctgccccgcc
      541 ggagcagcat catcaaggat ggcacgaagc agaaaagaga gcggaagaag accgtgtcat
      601 tcagcagcat gccaacagag aagaagatca gcagtgcaag cgactgcatc aactcaatgg
      661 tggagggctc tgaactcaag aaggttcgtt caaactccag aatttaccat cggtactttc
      721 tgctggacgc cgacatgcaa agcctgaggt gggagccatc caagaaggat tctgagaaag
      781 ccaagattga catcaagtcc atcaaggaag ttagaacggg gaaaaacaca gatatattcc
      841 gcagcaatgg catttctgag caaatatctg aagattgtgc gttttcagtc atatatggag
      901 aaaattatga gtcactcgat ttggttgcca attctgcaga tgttgcaaac atctgggtga
      961 caggactccg gtacctgatt tcttatggga aacatacact tgatatgtta gaaagtagcc
     1021 aagacaacat gaggacttgt tgggtttcac agatgtttag tgaaattgat gtagatgacc
     1081 ttggacatat aactctgtgt aatgctgttc agtgtatcag aaacctcaat cctggcttaa
     1141 aaacaagcaa aattgagctt aagttcaaag aactgcataa atcaaaggac aaaactggta
     1201 ctgaaatcac aaaggaagaa tttgttgagg tttttcatga actttgcact agacctgaaa
     1261 tttacttcct tttagttcag ttttcaagca ataaagaatt ccttgatacc aaggacctta
     1321 tgatgtttct tgaggcagaa cagggtgtag cacatataaa tgaggaaata agcctggaaa
     1381 ttattcacaa atatgagcca tccaaagaag gccaggaaaa gggctggctc tccatagatg
     1441 ggttcactaa ttacctgatg tcacctgatt gttacatctt tgatccggaa cataagaagg
     1501 tctgtcagga tatgaagcaa cctctgtctc attacttcat aaactcatct cataatacat
     1561 acttaataga ggaccagttc cggggtccct ctgacattac aggatatatc cgtgctctta
     1621 aaatgggttg caggagtgtt gagttggatg tgtgggatgg gccagataat gagcccgtga
     1681 tttacacagg ccacaccatg acctctcaga tagtcttccg cagtgtcatc gatatcatta
     1741 acaagtatgc attctttgct tctgagtatc ctctcatcct gtgtttagaa aatcattgtt
     1801 ctattaaaca acaaaaggtg atggttcaac acatgaagaa aattttagga gacaagctgt
     1861 ataccacatc acccaacatg gaggaatctt atctaccatc ccccgatgtc ctgaaaggga
     1921 aaatactaat caaagcaaag aagctgtctt caaattgctc tggtgtggaa ggggatgtta
     1981 ctgatgaaga tgaaggggca gaaatgtctc agaggatggg gaaagagaat gtggaacaac
     2041 ccaaccatgt gcctgtgaag cgatttcagc tttgcaaaga cctgtctgaa ctggtcagca
     2101 tctgtaagtc agtccagttc aaggagttcc aggtgtcgtt tcaggtgcag aagtactggg
     2161 aagtgtgttc attcaatgaa gtgctagcca gtaaatacgc caatgagaat cctggggact
     2221 ttgtaaatta caataagcgt ttcctcgcca gagtctttcc tagtccaatg agaattgatt
     2281 ctagtaacat gaaccctcaa gatttttgga aatgtggctg tcaaatcgta gccatgaact
     2341 ttcagactcc agggctaatg atggatctga acattggctg gtttaggcag aatggaaact
     2401 gtggctatgt tcttcgacca gccatcatga gggaagaagt ctccttcttc agtgccaaca
     2461 caaaggactc tgtccctgga gtttcgcctc agttgcttca catcaaaatc atcagtggcc
     2521 agaactttcc caagcccaaa gggtcaggtg ccaaagggga tgtggtggac ccttatgtct
     2581 atgtggaaat ccatggcatt cctgctgact gcgcagaaca gaggacgaaa actgtgaacc
     2641 agaatggaga tgctcctatg tttgatgaaa gctttgaatt tcaaatcaac ctccccgaac
     2701 tagccatggt gcgctttgta gtgctggatg atgactacat tggcgatgaa tttattggcc
     2761 agtacacgat tccctttgaa tgtttacaaa cgggctaccg ccatgtgcct ctgcagtcct
     2821 tgactggaga ggtccttgcc catgcttctc tgttcgtcca cgtggctatt actaacagaa
     2881 gaggaggagg gaagcctcat aaacggggcc tttctgtgag gaaagggaag aagtcccggg
     2941 aatatgcatc tctgagaaca ctgtggatta aaactgtaga tgaggtgttc aagaatgccc
     3001 agccccccat ccgggatgcc acagacctga gagagaacat gcagaatgca gtggtttctt
     3061 tcaaggaatt atgtggcctc tcctcagtgg ccaaccttat gcagtgcatg ctggccgtgt
     3121 ctcctcgatt cctggggcct gacaatactc ccctggtggt cttgaatctt agtgagccct
     3181 accccaccat ggaactgcag gccatcgtgc ctgaggttct gaagaagatc gtcacaactt
     3241 atgacatgat gattcagtcc ctcaaggcac tgattgaaaa tgcagatgct gtgtatgaaa
     3301 agattgtgca ctgtcagaag gcagccatgg aatttcatga acacttgcac agcataggca
     3361 ccaaggaggg actgaaggaa cggaaactac agaaggcggt ggagagcttt acctggaata
     3421 ttacgatttt aaagggacaa gcggaccttc tgaaatatgc taagaatgag accctggaga
     3481 acctgaagca gatccattat gcagccgttt cctgtggact gaacaaacca ggcaccgaaa
     3541 actcagaggc ccagaagcca cgccggagcc tggaagtgat ccccgagaaa accagtgatg
     3601 aaaatggaga ttaaggggcc tccccaagga ctccccactg aggaccagtc agcaagcgca
     3661 ctgctcactg attcggataa ggtctgggat attgtgcaca actggaatac ccaactgcag
     3721 gccatcacag ctgtgaatgt acgtagcaac ccacgtgtga aggcaaataa actctttaac
     3781 acgaaactct gtcctggccc aaacatgctg tctttgtata caaagcgccc tgagccccac
     3841 tgtgaaggac agtgcactgc tgtagttcct ctgtgaaagc agttcctcgg gtggaagtgg
     3901 atcggatggt tgaattcgta tttattggtg aaaccgtgaa tgtgcacacc taactggtgt
     3961 gtgtgtcccg gtcttggcac tgcaggggat ttggtggcct gcttgctgag ccgtatttac
     4021 cagcagaatg taagaaccca ggagctgagg gcagtgtgca gtgtggctgg gctgcctggc
     4081 taacgatgtg ctgtgtcagc atgggcagcc gagtggaagc cacaccttgt acatagtttt
     4141 tcattgtatg atgcagtggt cacattaaag atatctttta tggga
//
LOCUS       NM_001438269            3030 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 7, member 14 (Slc7a14),
            mRNA.
ACCESSION   NM_001438269
VERSION     NM_001438269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3030)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.10515.1,
                                           SRR26360194.1339752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               JAXUCZ010000002.1  113993589-113993922
            335-790             JAXUCZ010000002.1  114050039-114050494
            791-1027            JAXUCZ010000002.1  114069060-114069296
            1028-1245           JAXUCZ010000002.1  114071804-114072021
            1246-1392           JAXUCZ010000002.1  114079512-114079658
            1393-1601           JAXUCZ010000002.1  114082831-114083039
            1602-2479           JAXUCZ010000002.1  114085019-114085896
            2480-3030           JAXUCZ010000002.1  114099293-114099843
FEATURES             Location/Qualifiers
     source          1..3030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3030
                     /gene="Slc7a14"
                     /note="solute carrier family 7, member 14"
                     /db_xref="GeneID:499587"
                     /db_xref="RGD:1594375"
     exon            1..334
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            335..790
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    409..411
                     /gene="Slc7a14"
                     /note="upstream in-frame stop codon"
     CDS             487..2802
                     /gene="Slc7a14"
                     /note="probable cationic amino acid transporter; solute
                     carrier family 7 (cationic amino acid transporter, y+
                     system), member 14; solute carrier family 7 (orphan
                     transporter), member 14"
                     /codon_start=1
                     /product="solute carrier family 7 member 14"
                     /protein_id="NP_001425198.1"
                     /db_xref="GeneID:499587"
                     /db_xref="RGD:1594375"
                     /translation="MSGFLSSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGATSA
                     HGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSG
                     VCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDS
                     LANHTISRWMVDTVGTLNGLGKGEESYPDLLALVIAVIVTIIVALGVKNSVGFNNVLN
                     VLNLAVWVFIMIAGLFFVNGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGE
                     EAKNPNTSIPYAITASLVICLTAYVSVSMILTLMVPYYAIDTESPLMEMFVAHGFYAA
                     KFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSG
                     FLAALLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTK
                     KKEGILADCEKETCSPVSEGEEFSSPATNTCGAKNLPSLGDNEMLIGKSDKSAYNVNH
                     PNYGTVDMTTGIEADESENIYLIKLKKLIGPRYYTMRIRLGLPGKMDRPTAATGHTVT
                     ICVLLLFILMFIFCSFVIFGSEYISGQSWWAILLVVLMLLLITVLVFVILQQPENPKK
                     LPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLIYFGYGIWNSTLEIS
                     AREQALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPAEDKGFYYQQMSDAKAN
                     SRTSSKAKSKSKHKQNSEALIENDELDCSPE"
     misc_feature    613..2517
                     /gene="Slc7a14"
                     /note="cationic amino acid transport permease; Region:
                     2A0303; TIGR00906"
                     /db_xref="CDD:273330"
     misc_feature    613..2517
                     /gene="Slc7a14"
                     /note="cationic amino acid transport permease; Region:
                     2A0303; TIGR00906"
                     /db_xref="CDD:273330"
     exon            791..1027
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1245
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1392
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1601
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..2479
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..3030
                     /gene="Slc7a14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggaggcc gcacctggaa gttcaggaag gcgggtgagg tgtagtgagt gacagacccg
       61 gggagggggt ggggggagtg atgctaggac tcagtaatgg aaggggctgg attagccacg
      121 tgatgacaag gaggcggaga taggcaagct ggagagcaga ctggcaggcg cgggaggggt
      181 gcggaggggt ttcgatctga ataattgagg agcgattcag cagcagccgc tgcctcctgc
      241 cttcctttat caccaccacc gcctccatct cagctgtaag tgcagaccgc cggacattag
      301 catccaatcc agaccatcac ctccagcccc tctgaggttc atgcccaaga ccaggctgcc
      361 gtggctccca ctgggccttt cttaaaggga caagcactaa ttgctccatg agttccagaa
      421 tcatccactg aggcttccat agtccttttc catccgcaag ccttcactgc aacgctactg
      481 ttcaagatga gtggctttct gtcctcactg gacccccggc gggtacagtg gggggctgcc
      541 tggtatgcaa tgcactctcg gatcctgcgc accaagccgg tggagtccat gctggaagga
      601 actggggcca cctcagcgca cggtaccaag ctagcccagg tgctcaccac tgtagacctc
      661 atctctctcg gagtcggcag ctgtgtgggc acgggcatgt atgtggtgtc tggcctggtg
      721 gccaaggaga tggcaggacc tggggtcatc gtgtcattca ttatcgctgc tgtcgcatct
      781 attttatcag gtgtgtgcta tgcagagttt ggagttcgag tccccaagac cacaggatct
      841 gcctacacct acagctatgt cactgttggg gagttcgtgg cctttttcat tggctggaac
      901 ttgatcctgg agtacctgat aggcactgca gctggtgcca gtgccctgag cagtatgttt
      961 gactccctgg caaaccacac catcagccgc tggatggtgg acaccgtggg aaccctcaac
     1021 ggcctgggga aaggggagga atcataccca gaccttctgg ctctggtgat tgcggtcatt
     1081 gtgaccatca ttgtggctct gggtgtgaag aactccgtgg gcttcaacaa cgtcctcaat
     1141 gtgctgaacc tggcagtgtg ggtgttcatc atgatcgcag gcctcttctt cgtcaatggc
     1201 aaatactggg ctgaaggcca gttcctgccc cacggctggt caggggtgct gcagggagca
     1261 gccacgtgct tctatgcttt cattggcttt gacatcattg ccaccactgg cgaggaagcc
     1321 aagaacccca acacatccat cccgtatgcc atcactgcat ccctggtcat ctgcctgaca
     1381 gcgtatgtgt ctgtgagcat gatcttaact ctgatggtgc cctattatgc cattgacacg
     1441 gagtccccgc tcatggagat gtttgtggcc catggcttct atgctgccaa gtttgtagtg
     1501 gccattgggt cagtggcagg actgaccgtc agcttgctgg gttccctctt ccccatgccc
     1561 agggtcattt atgccatggc cggtgatggg ctgcttttca ggttcctggc tcatgtgagc
     1621 tcctacacag agacgccagt ggtagcttgc atcgtatcag gattcctggc ggctctcctc
     1681 tccctgctgg tgagcctgag ggacctgata gagatgatgt ccatcggcac gctcctcgcc
     1741 tacaccctgg tctctgtctg tgtcctgctt cttcgttatc agcctgagag cgacatcgat
     1801 ggttttgtca agttcctgtc tgaggagcac accaagaaga aggaaggcat cctggctgac
     1861 tgtgagaagg aaacttgttc tcccgtgagt gaaggggagg aattttccag cccagccacc
     1921 aacacctgtg gggccaagaa cctgccgtcc ttgggagaca atgagatgct catagggaaa
     1981 tcggataagt ccgcctacaa cgtcaaccac cccaactatg gcaccgtgga catgaccacc
     2041 ggcatagaag ccgatgaatc agaaaacatc tatctcatca agttgaagaa gctgatcgga
     2101 ccccgttact acacgatgag aatccggcta gggcttccag gcaaaatgga ccggcccacg
     2161 gcagcgaccg ggcacacagt gaccatctgc gtgctcctgc tgttcatcct catgttcatc
     2221 ttctgctcct tcgtcatctt tggctccgag tacatctcag gccagagctg gtgggccatc
     2281 cttctggttg ttctgatgct gctgctcatc accgtgctgg tgttcgtcat cctgcagcag
     2341 ccagagaacc ccaagaagct gccgtacatg gccccctgcc tcccctttgt gcctgccttt
     2401 gccatgctgg tgaatatcta tctcatgcta aagctctcca ccatcacatg gatccggttt
     2461 gcggtctggt gctttgtggg tatgctcatt tactttgggt atggtatctg gaacagcacc
     2521 ttggaaatca gcgcccgaga gcaggccctg caccaaagca cataccagcg ctacgacgtg
     2581 gatgacccct tttccgtgga ggaggggttc tcctatgcca ccgagggcga gagccaggag
     2641 gactggggtg ggccggctga ggacaaaggc ttctattacc aacagatgtc agatgcgaag
     2701 gcaaacagcc ggaccagtag caaagcgaaa agcaaaagca aacacaaaca gaactcggag
     2761 gccctgatcg agaatgacga gttagattgc tctcctgagt aaggcgcagg agcctagaga
     2821 gggtaaatca gcctgtgttc tagaaggtgg aaacttcttc cgactctcat ttcacaaacc
     2881 cagccttccc caaggtccat ccccaggcat aatctgtcat ttgctgtttc tgctgttcag
     2941 gggaataccg ttgaagggtt ttacccaggg cccttagcca gccctctcgt taaaaaaaaa
     3001 aaaaagtcaa aatcaaaaga ctccacgaaa
//
LOCUS       NM_001013217            1450 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus tripartite motif-containing 54 (Trim54), mRNA.
ACCESSION   NM_001013217 XM_343026
VERSION     NM_001013217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Chen,H., Chen,X., Yang,L., Sheng,S., Yang,J., Lu,Y., Sun,Y.,
            Zhang,X. and Jiang,C.
  TITLE     TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in
            rat tendon-derived stem cells
  JOURNAL   J Biol Chem 300 (1), 105510 (2024)
   PUBMED   38042492
  REMARK    GeneRIF: TRIM54 alleviates inflammation and apoptosis by
            stabilizing YOD1 in rat tendon-derived stem cells.
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Spencer,J.A., Eliazer,S., Ilaria,R.L. Jr., Richardson,J.A. and
            Olson,E.N.
  TITLE     Regulation of microtubule dynamics and myogenic differentiation by
            MURF, a striated muscle RING-finger protein
  JOURNAL   J Cell Biol 150 (4), 771-784 (2000)
   PUBMED   10953002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083706.1.
            
            On Apr 20, 2005 this sequence version replaced XM_343026.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1450
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="tripartite motif-containing 54"
                     /db_xref="GeneID:362708"
                     /db_xref="RGD:1306453"
     exon            1..352
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    29..31
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="upstream in-frame stop codon"
     CDS             185..1279
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 30"
                     /codon_start=1
                     /product="tripartite motif-containing protein 54"
                     /protein_id="NP_001013235.1"
                     /db_xref="GeneID:362708"
                     /db_xref="RGD:1306453"
                     /translation="MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQH
                     NLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVE
                     NIIDIYKQESSRPLHSKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEV
                     APLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQKFE
                     TLCAVLEERKGELLQALARVQEEKLQRVRSLIRQYGDHLEASSKLVESAIQSMEEPQM
                     ALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVIVEHVAEMLRTIDFQPGASG
                     DEEDDEVTLDGEEGNTGLEEERLDGPEGLH"
     misc_feature    254..430
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="RING finger, HC subclass, found in muscle-specific
                     RING finger protein 3 (MuRF-3) and similar proteins;
                     Region: RING-HC_MuRF3; cd16761"
                     /db_xref="CDD:319675"
     misc_feature    254..430
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="RING finger, HC subclass, found in muscle-specific
                     RING finger protein 3 (MuRF-3) and similar proteins;
                     Region: RING-HC_MuRF3; cd16761"
                     /db_xref="CDD:319675"
     misc_feature    554..682
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="B-box-type 2 zinc finger found in muscle-specific
                     RING finger protein 3 (MuRF-3) and similar proteins;
                     Region: Bbox2_MuRF3_C-II; cd19833"
                     /db_xref="CDD:380891"
     misc_feature    554..682
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="B-box-type 2 zinc finger found in muscle-specific
                     RING finger protein 3 (MuRF-3) and similar proteins;
                     Region: Bbox2_MuRF3_C-II; cd19833"
                     /db_xref="CDD:380891"
     misc_feature    686..817
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIH6.1);
                     Region: Mediates microtubule-binding and
                     homooligomerization. /evidence=ECO:0000250"
     misc_feature    746..1030
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    746..1030
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="coiled-coil (CC) domain of Drosophila brain tumor
                     (brat) and similar proteins; Region: CC_brat-like;
                     cl29238"
                     /db_xref="CDD:475168"
     misc_feature    1166..1276
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XIH6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            353..525
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            526..697
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            698..793
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1027
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1050
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1175
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1268
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1411
                     /gene="Trim54"
                     /gene_synonym="Rnf30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaatagcc cagggagaga ggagctgtta gaggaaggga caggaagcac cgctctttcc
       61 agagggagca atatcaggga tcccaagaat ctacagtcag cctaaactga cagcggaagg
      121 gcgcgcaggc agggggagag aaggccagca acagggccac agcaaggcac cagagcaccg
      181 cgggatgaac ttcacggtgg gtttcaagcc gctgctgggg gatgcacaca acatggacaa
      241 cctggagaag cagctcatct gccccatctg cctggagatg ttctccaagc ccgtggtgat
      301 cttgccgtgc caacacaacc tgtgccgcaa gtgtgccaac gacgtcttcc aggcctctaa
      361 ccctctgtgg caatcccggg gctccacaac tgtgtcttca ggaggacgtt tccgctgccc
      421 atcttgtagg cacgaggttg tcctggaccg gcatggcgtc tacggcctgc agcggaacct
      481 gctagtggag aatattattg acatctacaa acaggagtcc tcccggccac tgcactccaa
      541 ggctgaacag caccttatgt gtgaggaaca tgaagacgag aagattaaca tctactgtct
      601 gagctgtgag gtgcccacct gctctctctg caaggtcttt ggcgcccaca aggactgtga
      661 ggtggcccct ctgcccacca tttacaaacg ccagaagagt gagctgagtg acggcatcgc
      721 gatgctggtg gcaggcaacg accgtgtgca ggcagtgatc acgcagatgg aggaggtgtg
      781 ccagaccatt gaggacaaca gccgcagaca gaaacaactg ttaaaccaga agttcgagac
      841 cctgtgcgcg gttttggagg agcgcaaggg cgagttgctt caagcgctgg ctcgggtgca
      901 agaggagaag ctgcagcgcg tgcgtagcct catccgccag tacggagacc acttggaggc
      961 ctcctctaag ctggtggagt ccgccatcca gtccatggag gagccgcaga tggctctcta
     1021 cctccagcag gccaaggagc tgatcaacaa ggtcggggca atgtcgaagg tggagctggc
     1081 tggacggccg gagccaggct atgagagcat ggagcaattc tctgtgatcg tggagcacgt
     1141 ggcggaaatg ttgcggacca tcgacttcca gccgggcgcc tctggggatg aagaggatga
     1201 cgaggtgact ttggacgggg aagagggcaa cacagggctg gaggaggagc ggctggacgg
     1261 gccagaaggt ttgcactgat ccgactctga tccagagcgc acgcccggga gccaagggat
     1321 gctgaggatc tgcgcagaga ccatcgcgct acccatctcg gcctccaccc ccagggatgg
     1381 ttctcaataa agaactcatg tgtcccacgt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa
//
LOCUS       NM_001438178            5311 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 5 (Smc5),
            transcript variant 1, mRNA.
ACCESSION   NM_001438178 XM_006231183
VERSION     NM_001438178.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5311)
  AUTHORS   Raschle,M., Smeenk,G., Hansen,R.K., Temu,T., Oka,Y., Hein,M.Y.,
            Nagaraj,N., Long,D.T., Walter,J.C., Hofmann,K., Storchova,Z.,
            Cox,J., Bekker-Jensen,S., Mailand,N. and Mann,M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 5311)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   3  (bases 1 to 5311)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   4  (bases 1 to 5311)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   5  (bases 1 to 5311)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   6  (bases 1 to 5311)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (bases 1 to 5311)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (bases 1 to 5311)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 16, 2025 this sequence version replaced XM_006231183.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.7543.1,
                                           SRR26643291.4445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000001.1  230265372-230265641 c
            271-412             JAXUCZ010000001.1  230260591-230260732 c
            413-465             JAXUCZ010000001.1  230258553-230258605 c
            466-628             JAXUCZ010000001.1  230257157-230257319 c
            629-763             JAXUCZ010000001.1  230254913-230255047 c
            764-904             JAXUCZ010000001.1  230253016-230253156 c
            905-1066            JAXUCZ010000001.1  230251195-230251356 c
            1067-1138           JAXUCZ010000001.1  230248476-230248547 c
            1139-1394           JAXUCZ010000001.1  230242698-230242953 c
            1395-1549           JAXUCZ010000001.1  230241244-230241398 c
            1550-1663           JAXUCZ010000001.1  230230611-230230724 c
            1664-1758           JAXUCZ010000001.1  230227615-230227709 c
            1759-1891           JAXUCZ010000001.1  230225850-230225982 c
            1892-2065           JAXUCZ010000001.1  230223379-230223552 c
            2066-2235           JAXUCZ010000001.1  230223126-230223295 c
            2236-2359           JAXUCZ010000001.1  230220574-230220697 c
            2360-2482           JAXUCZ010000001.1  230220012-230220134 c
            2483-2608           JAXUCZ010000001.1  230211473-230211598 c
            2609-2653           JAXUCZ010000001.1  230208551-230208595 c
            2654-2749           JAXUCZ010000001.1  230208051-230208146 c
            2750-2854           JAXUCZ010000001.1  230207469-230207573 c
            2855-2974           JAXUCZ010000001.1  230207167-230207286 c
            2975-3154           JAXUCZ010000001.1  230199842-230200021 c
            3155-3250           JAXUCZ010000001.1  230199669-230199764 c
            3251-5311           JAXUCZ010000001.1  230196647-230198707 c
FEATURES             Location/Qualifiers
     source          1..5311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..5311
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
     exon            1..270
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3394
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="isoform 1 is encoded by transcript variant 1; SMC5
                     structural maintenance of chromosomes 5-like 1; structural
                     maintenance of chromosomes protein 5"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5
                     isoform 1"
                     /protein_id="NP_001425107.1"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
                     /translation="MATPSGKAAAPNPQASKRSLPRDASSEFPSKRKNSNPTSTLPRP
                     SGLFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKI
                     VEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNF
                     REKEKQLETSCKEKTEYLDKMIQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQRRTLEVRIKEKATDIKEA
                     SQKCKQRQDLIERKDRHIKELQQALTVKQNEEQDRQKRISNTRKMIEDLQNELRTAEN
                     CENLQPQIDAITNDLRRVQEEKALCEGEIIDKQREKEMLEKQKRSVSDHITRFDNLMN
                     QKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSND
                     LRAFVFESQEDMEIFLREVRDNKKLRVNAVIAPKISYADKAPSRSLNELKQYGFFSYL
                     RELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTS
                     FYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEINRKLEAVDSGLVALRDTNRH
                     LELKDNELRLKKKELLERKTKKRQLEQKISSKLASIRLMEQDTCNLEEEERKASTKIK
                     EINVQKAKLVTELTGLVKICTSLHIQKVDLILQNTTVISEKNKLEADYMASSSQLRVT
                     EQQFIELDDNRQRLLQKCKELMKRARQVCNLSADQAVPQEFQTQVPTIPNGHSSSPPM
                     AFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYTKREIEIQQLTEELKGKKVEL
                     DEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIR
                     IRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINE
                     RRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAF
                     QRRRRRITFTQPSQ"
     misc_feature    236..>673
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    236..>673
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    242..3241
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    242..3241
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
                     cl47134"
                     /db_xref="CDD:481474"
     misc_feature    323..346
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    323..346
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    617..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213179"
     misc_feature    617..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213179"
     misc_feature    <3008..3316
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    <3008..3316
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
     misc_feature    3056..3085
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213179"
     misc_feature    3056..3085
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213179"
     misc_feature    3128..3145
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213179"
     misc_feature    3128..3145
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="Walker B; other site"
                     /db_xref="CDD:213179"
     misc_feature    3152..3163
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    3152..3163
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="D-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    3233..3253
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213179"
     misc_feature    3233..3253
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213179"
     exon            271..412
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..465
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..628
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..763
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..904
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1066
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1138
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1394
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1549
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1663
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1758
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1891
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2065
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2235
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2359
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2482
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2653
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2749
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2854
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2974
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3154
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3250
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..5311
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttagcgcg ggagccgggc gcggaggctc ctgggctgcg gctcgccggg aacggaagcc
       61 gctgcgggac gcggaggaag ccaggatggc gactccgagt gggaaagctg ctgcccctaa
      121 cccccaggct tccaagaggt ctctcccgag agatgcttcc tccgagttcc cgagcaagag
      181 aaagaactcg aacccgacgt cgacgctgcc gcggccgtcc ggactcttcg tggagggctc
      241 aatcgtccgc atcgccatgg agaacttctt aacatatgac atctgtgaag tgtctcctgg
      301 gccccatctg aatatgatta ttggagccaa tggaacaggg aagtcaagca tagtgtgtgc
      361 catttgcctt ggcctagcag gcaagcctgc tttcatgggg cgtgcagata aggttgggtt
      421 tttcgtgaag agaggatgtt ccaaaggttt ggttgaaatt gaactgttca ggacttctgg
      481 aaatcttata atcacccgtg aaattgatgt gataaaaaat cagtcctttt ggttcatcaa
      541 caaaaaacct gtaacccaga agatagtgga agagcaagtc gcggccttga acatccaagt
      601 gggcaacctc tgccagttct tgcctcagga caaagttgga gaatttgcta aactcagtaa
      661 aattgaactc ctcgaagcta ctgagaagtc aattggtcct ccagagatgc acagatacca
      721 ctgtgaactc aagaacttca gggagaagga gaagcagcta gagacttctt gcaaagagaa
      781 aactgaatac ctagacaaaa tgattcagag aaatgaaagg tacaaacaag atgtagaaag
      841 attctatgaa cgaaaacgac atttagattt aattgagatg cttgaggcaa aaagaccatg
      901 ggtggaatat gagaatgtgc gtcaggaata tgaaggtgtg aaactagtcc gtgaccgagt
      961 gaaggaagag gtcagaaaac tcaaagaagg gcagattcct atgacacggc ggattgagga
     1021 aattgaaagg cagcgtcgca ctttggaagt tcgaatcaaa gaaaaggcaa ctgatattaa
     1081 ggaagcgtct cagaaatgca aacaaaggca ggacttgatt gagcggaagg acagacatat
     1141 taaggaactt cagcaagcat taacagtcaa gcagaatgag gagcaggacc ggcagaagag
     1201 aataagtaac acccgcaaga tgatagaaga cttgcagaat gagctcagga ctgcagaaaa
     1261 ctgcgagaac cttcagcctc agattgatgc catcacaaat gatctaaggc gtgttcaaga
     1321 ggagaaggca ttatgtgaag gcgagatcat tgataaacag agagaaaagg aaatgctgga
     1381 gaagcagaaa cggagtgtga gtgatcatat cacacgtttt gacaatctta tgaatcagaa
     1441 ggaagataag ctgagacaga ggtaccggga tacgtacgat gcagtcttgt ggctgagaaa
     1501 taacagagac aggtttaaac aaagagtctg tgagcccata atgctcacga ttaatatgaa
     1561 agataataaa aatgcaaaat atgttgaaaa tcatatttca tcaaatgact taagagcctt
     1621 tgtgtttgaa agtcaagaag atatggagat tttcctcaga gaggttcgtg acaataagaa
     1681 gttgagagta aatgctgtta ttgctcccaa gatttcatat gcagacaaag caccttcacg
     1741 atctctgaat gagttaaaac agtatggctt tttttcatac cttcgagagt tatttgatgc
     1801 acccgatcct gtgatgagtt acctttgctg ccaatatcat attcatgaag ttcctgtggg
     1861 aactgaaagg acccgagaaa gaattgaacg ggtaatacaa gaaactcgat taaaacagat
     1921 ttatacagca gaagaaaagt atgtgttaaa aacttctttc tattccaata aagttatctc
     1981 tagtaataca tctctgaaag tagcccagtt cctcactgtc actgtggacc tagagcaaag
     2041 gagacacttg gaagaacagc taaaggaaat taatagaaag ctggaagcag tggactcagg
     2101 attggtagcc ttgcgggata caaacaggca tctcgagctc aaagacaatg agctaaggct
     2161 gaagaagaag gagcttcttg aaagaaaaac caagaaaaga caactggaac agaaaattag
     2221 ctccaagctg gcaagtataa ggctgatgga acaggatact tgcaatctgg aagaggaaga
     2281 acgaaaagca agtaccaaaa taaaagaaat aaatgttcaa aaagcaaaac ttgttactga
     2341 attaacgggc cttgtaaaga tatgcacttc tttgcatatt caaaaagttg atttgattct
     2401 tcaaaatact acagtgatct ctgagaagaa caagttagaa gcagattaca tggcgtcctc
     2461 ctcacagctg cgtgtcacag aacaacagtt tattgaattg gatgacaata ggcagagatt
     2521 gttacagaag tgcaaggaac ttatgaagag agctaggcaa gtatgtaacc tgagtgcaga
     2581 ccaagccgtt ccccaagaat ttcagacaca agtacccacc attccaaatg gacacagctc
     2641 ctcacccccc atggcttttc aagatctccc aaacacattg gatgaaatcg atgcattatt
     2701 aactgaagaa agatcaagag cgtcctgctt cacaggactg aatccttcgg tggttgagga
     2761 gtacacaaaa agagaaatag aaatacagca gttaactgaa gaactaaagg ggaagaaagt
     2821 tgaattagat gaatacaggg aaaacatttc gcaggtgaaa gaaaggtggc tgaacccctt
     2881 aaaagagcta gtagagaaaa tcaatgagaa gttcagcaac ttttttagtt ccatgcagtg
     2941 tgctggtgaa gttgatcttc atacagaaaa tgaggaagat tatgataaat atggaatccg
     3001 gattagagta aaatttcgca gtagtactca gctgcatgaa ttaactcctc atcatcaaag
     3061 tggcggtgaa agaagtgttt ctaccatgct gtacttgatg gcacttcagg agcttaacag
     3121 atgtccattc agagtggttg atgaaattaa tcagggtatg gacccaatta atgaacggag
     3181 ggtgtttgaa atggttgtga acaccgcctg taaagagaac acatcgcagt acttcttcat
     3241 cacaccgaag cttctacaga atctgcctta ttctgaaaag atgacggtat tgtttgtcta
     3301 caatggtcct catatgctgg aaccaaaccg atggaattta aaggcttttc aaaggcggcg
     3361 gcgaaggatc acatttactc aaccttctca gtgaaaggaa agggaggggc ctgccgaggt
     3421 tttcatttaa ctgtttatac ctgtcgctca agtgaataaa agttagcaga tttattgaaa
     3481 gagaaagatt ggttattttt ggaagcctgc ttttaaaaac aaataggtta atgaagcgga
     3541 gaccatagtg actctggacc atttctagtg aaaactaagt cttcagtttt ggtggacctt
     3601 gtctcattag tcctctgtga gcattgttgt gtgaagcttt gtgctgcctc aggtgtggtg
     3661 gcacacatct agtccagcat ttaggagacg gaggcagaaa gatcatgagt ttgagtggtt
     3721 tcatgtgtct taacagaaaa agctatttcc ggttgcaaat cagaggtacg gcagaatggg
     3781 gtttcattca cagagcgttt acaaacaata gccgccctga gtgctgattg cagaacatcc
     3841 tgactcttag tgcttaaagg taactcagaa ttagaaatcc catttgcctt cagtattgta
     3901 tttagttttt aaaaactagt atgagaatgt ctgcttagta gatagtgatt tatggcagat
     3961 ctgttcattt ctttgtgttt agaagaaggg ttcccttatt ttcatagaaa atatgttatc
     4021 gtagaaaatt gatgctataa ttttattgtt atttcaaaga attgggaaga catatacacg
     4081 tgaggcttca aaatgacagg aggactttga gaggtcacaa ggtaaagatg atacagaatg
     4141 tggcccaaac attggcagag tgaaatcagg tgacaggagt taaagtataa ttgttgtgtg
     4201 tgtttgtcgg gggtgggttc tttgtttgtt tgtttaattt aaagtcaaat gtattttaca
     4261 tcttaaattt ctacaaaggc atttttataa ttttagtaag atttttctta agatttcata
     4321 tatgagattt tacaatttgt atttgaaatt tctcagtgct atgtaaagag tgaaggcaaa
     4381 gaattgattg gtttcaaatc ataatatttt tagaatttgt atgtccttcc ttctacccag
     4441 tattttagaa aactctcatc taaattgttt tcttccagct tgaaaatatt aattgaaaac
     4501 catttatttt tctctgagaa tgctaattaa caatgccaaa caaattctgt ttgtttgttt
     4561 tttttttaaa caaatcttga aagaaagtag aaatgtcttt gaatagtgga ctgaactgta
     4621 tccttgctgg tactgacaaa attatttttg tgactagcta gcctgaataa agtttgggct
     4681 ttgtatatta ttgtaatagc caatgagatt tgcattctta ttaggtcaaa aaatagtgaa
     4741 acatgagttt atgtctgctc acttagacat tttctctttt agaagttgta tttcttttta
     4801 acacttgtaa aagaaccctt ccctcttaaa ctacatctca tacatgtagt ataaagatat
     4861 ttttaataac atttttatca gcatgaacaa gtcaaaaaat taaaaactag gtaggatagt
     4921 agtgaagggt gtttctaaac atttgtgtcg ttgcttggat ttctgacata attaatatct
     4981 tcactgatat atgcttaata tagtttggtt ttatcatgtc aatgtgaaac aaaaacaaac
     5041 cgtacttaaa actcaacatc agcaatccca tttcagttta catatgtcaa aaatgattct
     5101 atatcatgct tataaacttt cagagagcaa aattaatgtt cgttttatat tgactttggg
     5161 ctgggaagga taaattatgt atcatttatt atattaaaaa tagtcatact ataatgtcat
     5221 tttctgcaac tgttgatttt taagattata ttataattgt aaaaattcca agtaaaagct
     5281 tgatttgata aataaaatat ttaaaacctg a
//
LOCUS       NM_001438297             711 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12),
            transcript variant 2, mRNA.
ACCESSION   NM_001438297 XM_006228652
VERSION     NM_001438297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 711)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   3  (bases 1 to 711)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 711)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced XM_006228652.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI294944.1, DV728626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000001.1  93156283-93156306   c
            25-92               JAXUCZ010000001.1  93155999-93156066   c
            93-711              JAXUCZ010000001.1  93153424-93154042   c
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..711
                     /gene="Mrps12"
                     /note="mitochondrial ribosomal protein S12"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
     exon            1..24
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     exon            25..92
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..463
                     /gene="Mrps12"
                     /note="isoform 1 is encoded by transcript variant 2; 28S
                     ribosomal protein S12, mitochondrial; small ribosomal
                     subunit protein uS12m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12m isoform 1"
                     /protein_id="NP_001425226.1"
                     /db_xref="GeneID:292758"
                     /db_xref="RGD:1306221"
                     /translation="MSWPGLLHGLTTSLSRGLALAPQLWATRSMATLNQMHRLGRPKE
                     PPKRLGPTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTL
                     QEHHVVLVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK"
     misc_feature    137..457
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    137..457
                     /gene="Mrps12"
                     /note="S12-like family, 30S ribosomal protein S12
                     subfamily; S12 is located at the interface of the large
                     and small ribosomal subunits of prokaryotes, chloroplasts
                     and mitochondria, where it plays an important role in both
                     tRNA and ribosomal subunit...; Region: Ribosomal_S12;
                     cd03368"
                     /db_xref="CDD:239466"
     misc_feature    order(140..145,149..154,161..166)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    order(140..145,149..154,161..166)
                     /gene="Mrps12"
                     /note="S17 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:239466"
     misc_feature    140..142
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    140..142
                     /gene="Mrps12"
                     /note="S8 interaction site [active]"
                     /db_xref="CDD:239466"
     misc_feature    order(164..172,203..205,209..214,218..220,263..268,
                     272..280,299..301,323..325,332..337,374..379,389..394,
                     455..457)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(164..172,203..205,209..214,218..220,263..268,
                     272..280,299..301,323..325,332..337,374..379,389..394,
                     455..457)
                     /gene="Mrps12"
                     /note="16S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(254..259,389..391)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(254..259,389..391)
                     /gene="Mrps12"
                     /note="streptomycin interaction site [chemical binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    257..262
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    257..262
                     /gene="Mrps12"
                     /note="23S rRNA interaction site [nucleotide binding];
                     other site"
                     /db_xref="CDD:239466"
     misc_feature    order(260..277,335..361)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     misc_feature    order(260..277,335..361)
                     /gene="Mrps12"
                     /note="aminoacyl-tRNA interaction site (A-site)
                     [nucleotide binding]; other site"
                     /db_xref="CDD:239466"
     exon            93..711
                     /gene="Mrps12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgaccct gctagtttgg taagggacgc agcctgcggc gagatgtcct ggcccggcct
       61 tctccatggc ctcaccacgt ccctcagtcg tggcctagcc ctagctcccc agctctgggc
      121 cacccgttcc atggccaccc tgaaccagat gcaccgctta ggccgcccga aggaaccccc
      181 taagcgtctg ggccccacgg agggccggcc ccagctgaag ggtgtggtgt tgcgcacatt
      241 tatcaggaag ccgaagaagc ccaactccgc caaccggaag tgctgccgag tacgcctcag
      301 caccggcaaa gaggctgtct gcttcatccc cggcgagggc cacaccctgc aggagcacca
      361 cgtggtcctc gtggagggtg gtcgcaccca ggacctgcct ggggttaaac tcaaagttgt
      421 gaggggcaag tatgactgcg gccacgtgca gaagaagaaa tgaccataat tcacagtgat
      481 ctgctactgg atccttggaa acgggttctt tctgctccag gggcagcttt tcttgggttc
      541 aaatcttact ctgactcagc aagatgctat taacctgcaa gatttctgaa ggtgaattgg
      601 aaggaggaac tcttgtgccc actcccttga cttccatgtt cagtgtctgc aggttgacct
      661 catgcgctgg gatgggggtt gtaataaaca tatcttcagg ttgtgatgtc a
//
LOCUS       NM_001438265            1488 bp    mRNA    linear   ROD 20-APR-2025
DEFINITION  Rattus norvegicus KLF transcription factor 13 (Klf13), mRNA.
ACCESSION   NM_001438265
VERSION     NM_001438265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Gu,M., Wang,J., Wang,Y., Xu,Y., Zhang,Y., Wu,W. and Liao,S.
  TITLE     MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2
            cardiomyocytes via down-regulating KLF13 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (3), 288-297 (2018)
   PUBMED   29377979
  REMARK    GeneRIF: Data show that Kruppel-like factor 1 (KLF13) was a
            downstream target of miR-147b.
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Bayoumi,A.S., Park,K.M., Wang,Y., Teoh,J.P., Aonuma,T., Tang,Y.,
            Su,H., Weintraub,N.L. and Kim,I.M.
  TITLE     A carvedilol-responsive microRNA, miR-125b-5p protects the heart
            from acute myocardial infarction by repressing pro-apoptotic bak1
            and klf13 in cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 114, 72-82 (2018)
   PUBMED   29122578
  REMARK    GeneRIF: the improvement of cardiac function and structure elicited
            by miR-125b-5p is in part attributed to repression of the
            pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Gordon,A.R., Outram,S.V., Keramatipour,M., Goddard,C.A.,
            Colledge,W.H., Metcalfe,J.C., Hager-Theodorides,A.L., Crompton,T.
            and Kemp,P.R.
  TITLE     Splenomegaly and modified erythropoiesis in KLF13-/- mice
  JOURNAL   J Biol Chem 283 (18), 11897-11904 (2008)
   PUBMED   18285334
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Martin,K.M., Cooper,W.N., Metcalfe,J.C. and Kemp,P.R.
  TITLE     Mouse BTEB3, a new member of the basic transcription element
            binding protein (BTEB) family, activates expression from GC-rich
            minimal promoter regions
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 529-533 (2000)
   PUBMED   10642511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.1569026.1,
                                           SRR22582424.1710311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840112, SAMN12840113
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1071              JAXUCZ010000001.1  126960278-126961348 c
            1072-1488           JAXUCZ010000001.1  126917655-126918071 c
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1488
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="KLF transcription factor 13"
                     /db_xref="GeneID:499171"
                     /db_xref="RGD:1565099"
     exon            1..1071
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    339..341
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="upstream in-frame stop codon"
     CDS             492..1361
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="Kruppel-like factor 13"
                     /codon_start=1
                     /product="Krueppel-like factor 13"
                     /protein_id="NP_001425194.1"
                     /db_xref="GeneID:499171"
                     /db_xref="RGD:1565099"
                     /translation="MAAAAYVDHFAAECLVSMSSRAVVHEPREGPEPRPEGAAAAAPT
                     LPRVDERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPAPP
                     APPPGPEPASPGQAGAPAAPPSPAWSEPEAALEPEPGPAGSGEPGLRQRGRRGRSRAD
                     LESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQECNKKFARSDELARH
                     YRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRS
                     DASSPTISPASSP"
     misc_feature    510..998
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="N-terminal domain of Kruppel-like factor 13;
                     Region: KLF13_N; cd21571"
                     /db_xref="CDD:409236"
     misc_feature    510..998
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="N-terminal domain of Kruppel-like factor 13;
                     Region: KLF13_N; cd21571"
                     /db_xref="CDD:409236"
     misc_feature    <978..1250
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <978..1250
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    999..1067
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    999..1067
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1020..1022,1026..1028,1032..1034,1038..1043,
                     1050..1055,1062..1064,1110..1112,1116..1118,1128..1133,
                     1140..1145,1152..1154,1194..1196,1200..1202,1206..1208,
                     1212..1217,1224..1229,1236..1238)
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1020..1022,1026..1028,1032..1034,1038..1043,
                     1050..1055,1062..1064,1110..1112,1116..1118,1128..1133,
                     1140..1145,1152..1154,1194..1196,1200..1202,1206..1208,
                     1212..1217,1224..1229,1236..1238)
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1089..1157
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1089..1157
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1089..1091,1104..1106,1143..1145,1155..1157)
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1089..1091,1104..1106,1143..1145,1155..1157)
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1179..1241
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1179..1241
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            1072..1488
                     /gene="Klf13"
                     /gene_synonym="RGD1565099"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttcgtgc gcgctgctcc ctgcggccgc tgccgcctgt aacctgcgcc gccaggatgt
       61 ggctgggggc tgacgtcggg tccagatgtg gccccggccc cgcccacccc cggggccggt
      121 ccgcccacac cgagccgcgg cgcgcacgga ggctgtcccg cctgccacaa tgcacggtgg
      181 aactgcgacc gcaacttgca ggggtcgtgc ctaacgtcgc cgccgctcga cgtccctagg
      241 acaggccggt tctgacgccg cacgcggacc cacctcactg gagcccccca tgcgctcacc
      301 ctccagtgcc cggccaggag gacgcggagc cgcgcgggtg acggcagaag cggctacgcg
      361 cccagcctag cccagcccag ccggagaaga gggcgcgccg cgcccccgcc ccccgccgct
      421 ctccggaggc cgtgggtgcg gatgcgccgc tgacgactcc tgcgagagca ccgcgcgccc
      481 gagcccgcag catggcagcc gccgcctatg tggaccactt tgccgccgag tgcctcgtgt
      541 ccatgtccag ccgcgcagtc gtgcacgagc cgcgggaagg acctgaaccc cggcccgagg
      601 gcgcggccgc cgccgccccc acactgcccc gcgttgacga gcgccgcgac ggcaaggaca
      661 gcgcctctct tttcgtggta gctcggatcc tagcggacct caaccagcag gcgccggccc
      721 ccgcccccgc ggaacgcaga gaaggggctg ctgcgcgcaa ggcgaggacc ccctgccgcc
      781 tgccgcccgc gccccctgcg ccgccgcccg gcccagagcc cgcttcccct ggacaagcag
      841 gcgcgccggc cgcgcccccc agccccgcgt ggagcgagcc cgaggcggca ttggagccag
      901 agccgggccc cgcggggagc ggcgagcctg gcctcagaca aaggggtcgg cggggccgca
      961 gccgcgcgga cctcgagtcc ccgcagagga agcacaagtg ccactacgcg ggctgcgaga
     1021 aagtttacgg gaaatcttcg cacctcaagg cgcacctgag aactcacaca ggtgagaggc
     1081 cctttgcctg cagctggcag gagtgcaaca agaagttcgc gcgctccgac gagctggccc
     1141 gacactatcg cacgcacacg ggcgagaaga agttcagctg ccccatctgc gagaagcgct
     1201 tcatgcggag cgaccacctg acgaagcacg cacgccgcca cgccaacttc catcccggca
     1261 tgctgcagcg gcgtggcggg ggctcgagga ccggctcgct cagcgactac agccgctcgg
     1321 atgccagcag ccccaccatc agcccggcca gctcaccctg agcacccgca cccggaccgc
     1381 gcctcctcgc ccctttggta ataggaaagc tgagcgaact tgagaagtcc acagcaaaac
     1441 agttttcttc acctcaggtg tcaattttta acaaaaaagg aaaaaaaa
//
LOCUS       NM_001438361            2473 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7),
            transcript variant 2, mRNA.
ACCESSION   NM_001438361 XM_063272737
VERSION     NM_001438361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2473)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2473)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2473)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2473)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2473)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2473)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2473)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2473)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2473)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2473)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_063272737.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.6859.1,
                                           SRR22399481.396230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000001.1  208444568-208444623
            57-269              JAXUCZ010000001.1  208450269-208450481
            270-492             JAXUCZ010000001.1  208451583-208451805
            493-583             JAXUCZ010000001.1  208452757-208452847
            584-797             JAXUCZ010000001.1  208453456-208453669
            798-1002            JAXUCZ010000001.1  208455552-208455756
            1003-1134           JAXUCZ010000001.1  208457746-208457877
            1135-2473           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2473
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..56
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Dhcr7"
                     /note="upstream in-frame stop codon"
     exon            57..269
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1599
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_001425290.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     misc_feature    289..351
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    448..1596
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    448..1596
                     /gene="Dhcr7"
                     /note="Isoprenylcysteine carboxyl methyltransferase (ICMT)
                     family; Region: ICMT; cl21511"
                     /db_xref="CDD:473892"
     misc_feature    466..528
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    613..675
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    700..762
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    880..942
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    967..1029
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1087..1149
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1162..1224
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     misc_feature    1429..1491
                     /gene="Dhcr7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2Z8.1);
                     transmembrane region"
     exon            270..492
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            493..583
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            584..797
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1002
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1134
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2473
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttag ggcgctgctg gagctcgtga atcaaccgcc cggatcccgc acgcagaacc
       61 tgcggtgggc gatcaggtac tgagaaagct accaaggttg cctgctctac tcagcacttg
      121 agccctggtg ggggtctatc tttctggaag gatctgagcc tctcctcctt ccctcagatc
      181 ctgatggctt caaagtccca gcacaacgct tccaaagcca agaatcacaa cgtcaaggct
      241 gaatctcaag gacaatgggg ccgtgcctgg gaagtggact ggttctccct ggtcagcgtc
      301 attttcctgc tgctcttcgc accgttcatt gtgtactact tcatcatggc atgtgaccag
      361 tacagctgct cgctgactgc ccccatattg gacgtagcta caggccgtgc gagtctggca
      421 gacatctggg ccaagacacc gcctgtgaca gctaaggctg cccaactgta tgccttgtgg
      481 gtcagcttcc aggtgctgct ttactcctgg cttcctgact tctgccacag atttctgcca
      541 ggttatgtgg gaggcgtcca agaaggtgcc ataactccag cagggattgt aaataagtat
      601 gaggtgaatg ggctgcaagc ctggctcatt acccacttcc tctggtttgt gaacgcttac
      661 ctcctatcct ggttctcccc caccatcatc tttgacaact ggatcccgtt gctatggtgt
      721 gccaacatcc tgggctacgc tgtgtccacc tttgcaatga tcaaggggta cctgttcccc
      781 accagcgccg aagactgcaa attcacaggc aatttcttct acaactacat gatggggatt
      841 gagttcaacc cccgcatcgg aaagtggttt gacttcaagc tgttcttcaa tgggcgcccg
      901 gggattgtgg cctggactct tatcaacctg tcctttgctg ccaagcagca ggagctttat
      961 ggccatgtga ccaactccat gattttggtc aatgtcttac aggccatcta tgtgttagac
     1021 ttcttctgga acgaaacctg gtacctgaag accattgaca tctgccatga ccactttgga
     1081 tggtacctgg gctggggaga ttgcgtgtgg ctgccctacc tctacacact gcagggcctg
     1141 tacttggtgt accaccctgt acagctctcc acccccaacg ccttgggcgt cctgctgctc
     1201 ggcctggtgg gttactatat cttccgaatg accaaccatc agaaggacct gttccgccgg
     1261 acagatggac actgcctcat ctggggcaag aaacccaagg ccatcgagtg ctcctacacg
     1321 tcagccgacg ggctgaagca ccgcagcaag ctgttggttt caggcttctg gggtgtggcc
     1381 cgccacttca actataccgg agacctgatg ggcagcctcg cctactgcct ggcttgtggc
     1441 ggcggccacc tcctccccta cttctacatc atctatatga ctatcctgct tacccaccgc
     1501 tgcctccgtg atgagcaccg ctgtgccaac aagtatggcc gtgactggga gcgctacgta
     1561 gccgctgtgc cctaccgcct gctgcctggg atcttctgag ggccaccctg gcaagcagaa
     1621 agaggcgtca ttgaatgtgt ggagttgggt gcatgggggc cagcgtccgg ctttcccctg
     1681 caggggcctc cttggtttgc tcttctggag gatggagagc caggcgcccc acagtgtctg
     1741 gctggtggca gctagagctg agttcacact gatgccccag cagaatgact ggttctccct
     1801 gttcagcatc ctgagggcag aggaccttgg ccctttcatg tctgttggaa gcccaccatc
     1861 tatgttgtct agatagctta ggcttaccag gtgtctccca ggattgggcc atcctggtaa
     1921 actggagaca atgtaggatc taaagagttt ggcaatgtca ccttcactcc cacctgcaat
     1981 ggtgggctgg accccttttt ctgtctgtag tgtgatcagc agagggttca ggggccattg
     2041 aaggaggaag gctctttgtt taggttcttt actgttttta cccgaggaat gccaagcagc
     2101 ggactggaat atcccactct gcacatccct ggctgacttg ataaagtctg tctgacatat
     2161 gagatggggt tcccagaact ccccaagtac cccagctagc agcttatcca tctcccctct
     2221 tccggaaggt gcttcttgtt tacccctgag acttggctca gaggtgaaca gacttggctc
     2281 tgacaaccca gaatgtatca ccagttagtg gcctcagcca caccttcccc aacaggagaa
     2341 ccagcgttgg ggaaggaatc cattctcatt agtgacactg ccccccaaaa ctcagggtta
     2401 ttttgtaaaa ctagataggc tcatgttagc cttgcaagcg gttctttgta ttaaatctgc
     2461 cttgttaaat gag
//
LOCUS       NM_001438371            2016 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus lipolysis stimulated lipoprotein receptor (Lsr),
            transcript variant 1, mRNA.
ACCESSION   NM_001438371 XM_006228844
VERSION     NM_001438371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Wang,J., Qin,M., Wu,Q., Yang,H., Wei,B., Xie,J., Qin,Y., Liang,Z.
            and Huang,J.
  TITLE     Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight
            Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis
  JOURNAL   Biomed Res Int 2022, 4234186 (2022)
   PUBMED   35463981
  REMARK    GeneRIF: Effects of Lipolysis-Stimulated Lipoprotein Receptor on
            Tight Junctions of Pancreatic Ductal Epithelial Cells in
            Hypertriglyceridemic Acute Pancreatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Sohet,F., Lin,C., Munji,R.N., Lee,S.Y., Ruderisch,N., Soung,A.,
            Arnold,T.D., Derugin,N., Vexler,Z.S., Yen,F.T. and Daneman,R.
  TITLE     LSR/angulin-1 is a tricellular tight junction protein involved in
            blood-brain barrier formation
  JOURNAL   J Cell Biol 208 (6), 703-711 (2015)
   PUBMED   25753034
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Furuse,M., Oda,Y., Higashi,T., Iwamoto,N. and Masuda,S.
  TITLE     Lipolysis-stimulated lipoprotein receptor: a novel membrane protein
            of tricellular tight junctions
  JOURNAL   Ann N Y Acad Sci 1257, 54-58 (2012)
   PUBMED   22671589
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Yagil,C., Hubner,N., Monti,J., Schulz,H., Sapojnikov,M., Luft,F.C.,
            Ganten,D. and Yagil,Y.
  TITLE     Identification of hypertension-related genes through an integrated
            genomic-transcriptomic approach
  JOURNAL   Circ Res 96 (6), 617-625 (2005)
   PUBMED   15731461
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Yen,F.T., Masson,M., Clossais-Besnard,N., Andre,P., Grosset,J.M.,
            Bougueleret,L., Dumas,J.B., Guerassimenko,O. and Bihain,B.E.
  TITLE     Molecular cloning of a lipolysis-stimulated remnant receptor
            expressed in the liver
  JOURNAL   J Biol Chem 274 (19), 13390-13398 (1999)
   PUBMED   10224102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006228844.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100626.1, AF119668.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000001.1  95329045-95329339   c
            296-640             JAXUCZ010000001.1  95327858-95328202   c
            641-760             JAXUCZ010000001.1  95321993-95322112   c
            761-907             JAXUCZ010000001.1  95318220-95318366   c
            908-1069            JAXUCZ010000001.1  95315234-95315395   c
            1070-1129           JAXUCZ010000001.1  95315054-95315113   c
            1130-1261           JAXUCZ010000001.1  95314834-95314965   c
            1262-1890           JAXUCZ010000001.1  95314043-95314671   c
            1891-2016           JAXUCZ010000001.1  95313830-95313955   c
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2016
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
     exon            1..295
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    190..192
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="upstream in-frame stop codon"
     CDS             202..1926
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lipolysis-stimulated remnant receptor;
                     liver-specific bHLH-Zip transcription factor 7;
                     lipolysis-stimulated receptor"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 1 precursor"
                     /protein_id="NP_001425300.1"
                     /db_xref="GeneID:64355"
                     /db_xref="RGD:69236"
                     /translation="MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDP
                     YHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLDWLFVVVVCLASLLLFLLLGICWCQCCPHTCC
                     CYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMGP
                     PYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEK
                     ELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPQSP
                     RTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPP
                     RSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRDAGFRSRDPQ
                     YDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASRERRLKKNLA
                     LSRESLVV"
     sig_peptide     202..309
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     exon            296..640
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            641..760
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            761..907
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1069
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1129
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1261
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1890
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2016
                     /gene="Lsr"
                     /gene_synonym="Lisch7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtcccc gggaagccga aggcatgagc ttcgcccaag ttctttttat gggttagaac
       61 tcctccagag cggggaaaaa gaacttggaa taggggcggg acggagcacg cacccttctc
      121 cgccttggtt ctcgccgcgc cccctactct cgggatactt gggaggggac gcgcgggcac
      181 cgtcgctgct agacggccgc gatggcgccg gcggccggcg cgtgtgctgg ggcgcctgac
      241 tcccacccag ctaccgtggt cttcgtgtgt ctctttctca tcattttctg cccagaccct
      301 gccagtgcca tccaggtgac tgtgtctgac ccctaccacg tagtgatcct gttccagcca
      361 gtgaccctgc cctgcaccta tcagatgagc aacactctca cagtccccat cgtgatctgg
      421 aagtacaagt cattctgccg ggaccgtatt gccgatgcct tctctcctgc cagtgtggac
      481 aaccagctaa atgcccagtt ggcagctggc aaccccggct acaaccccta tgtggagtgc
      541 caggacagtg tacgcactgt cagggtggtg gccaccaaac agggcaatgc ggtgaccctg
      601 ggagactact accaaggcag gaggatcacc ataacaggaa atgctgacct gaccttcgag
      661 cagacagcct ggggagacag tggagtgtat tactgctctg tggtctcggc ccaagatctg
      721 gatggaaaca acgaggcgta cgcagagctc atcgtccttg attggctctt tgtggtcgtg
      781 gtctgcctgg cgagcctcct cctcttcctc ctcctgggca tctgctggtg ccagtgctgt
      841 cctcacacct gctgctgcta tgtccgatgt ccctgctgcc cagacaagtg ctgttgccct
      901 gaggctcttt atgctgctgg caaagcagcc acctcaggtg tcccgagcat ctatgccccc
      961 agcatctata cccacctctc acctgccaag accccaccac ctccgcctgc catgattccc
     1021 atgggccctc cctatgggta ccctggagac tttgacagac atagctcagt tggtggccac
     1081 agctcccaag tacccctgct gcgtgacgtg gatggcagtg tatcttcaga agtacgaagt
     1141 ggctacagga tccaggctaa ccagcaagat gactccatga gggtcctata ctatatggag
     1201 aaagagctag ccaactttga cccttcccga cctggccctc ccaatggcag agtggaacgg
     1261 gccatgagtg aagtaacctc cctccatgaa gatgactggc gatcgaggcc ttccagggct
     1321 cctgccctca cccccatcag ggatgaggag tggaatcgcc actccccaca gagtcccaga
     1381 acatgggagc aggaacccct tcaagaacaa ccaaggggtg gttgggggtc tggacggcct
     1441 cgggcccgct ctgtggatgc tctagatgat atcaaccggc ctggctccac tgaatcagga
     1501 cggtcttctc ccccaagtag tggacggaga ggacgagcct atgcacctcc aagaagtcgc
     1561 agccgggatg acctctatga cccggacgat cctagggact tgccacattc ccgagatccc
     1621 cactattatg acgacatcag gtctagagat ccacgtgctg accccagatc ccgtcagcga
     1681 tcccgagatc ctcgggatgc tggcttcagg tcaagggacc ctcagtatga tgggcgacta
     1741 ttagaagagg ctttaaagaa aaaggggtcg ggcgagagaa ggagggttta cagggaggaa
     1801 gaagaggaag aggagggcca atacccccca gcacctccac cttactcaga gactgactcg
     1861 caggcctcac gggagaggag gctgaaaaag aatttggccc tgagtcggga aagtttagtc
     1921 gtctgatcca cgttttgtat gtagcttttg tacttttttt tttaattgga atcaatattg
     1981 atgaaacttc aagcctaata aaatgtctaa tcacaa
//
LOCUS       NM_001438403             938 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            transcript variant 1, mRNA.
ACCESSION   NM_001438403 XM_006230898
VERSION     NM_001438403.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 938)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 938)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 938)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 938)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 938)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 938)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 938)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 938)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 938)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 938)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230898.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.3979.1,
                                           SRR26643287.3009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000001.1  213563363-213563416
            55-237              JAXUCZ010000001.1  213563668-213563850
            238-428             JAXUCZ010000001.1  213570794-213570984
            429-938             JAXUCZ010000001.1  213571525-213572034
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..938
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     exon            1..54
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..237
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..554
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="isoform 1 is encoded by transcript variant 1; bcl2
                     antagonist of cell death; bcl-2-binding component 6;
                     bcl-xL/Bcl-2-associated death promoter; Bcl2-antagonist of
                     cell death; bcl-2 associated death agonist;
                     bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death isoform 1"
                     /protein_id="NP_001425332.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIV
                     QQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWA
                     AQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGST
                     PSQ"
     misc_feature    63..551
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     misc_feature    63..551
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="Pro-apoptotic Bcl-2 protein, BAD; Region:
                     Bcl-2_BAD; pfam10514"
                     /db_xref="CDD:402236"
     exon            238..428
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..938
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactggag agaggaggca ggcccgagtc aggggcctcg agaacgggct tgggcccaga
       61 gtatgttcca gatcccagag tttgagccga gtgagcagga agacgctagt actacagata
      121 ggggcctggg ccctagcctc actgaggacc agccaggtcc ctacctggcc ccaggtctcc
      181 tggggagcat cgttcagcag cagccgggac aggcagccaa taacagtcat catggaggcg
      241 ctgggactat ggagacccgg agtcgccaca gttcgtaccc agcggggact gaggaagatg
      301 aagggatgga ggaggagctt agcccttttc gaggacgctc gcgctcggct ccccccaatc
      361 tctgggcagc gcagcgctat ggccgtgagc tccgaagaat gagcgatgaa tttgagggtt
      421 ccttcaaggg acttcctcgc ccaaagagcg caggcactgc aacacagatg cgacaaagcg
      481 ccagttggac gcgcattatc cagtcctggt gggatcgaaa tttggggaaa ggaggctcca
      541 ctccctccca gtgatctgct ccacattccc ggaattctac ccgctcccat cgcccgccat
      601 attgggtgtg ggcggaagtc tttcgaggcc ttaggaaaaa aggatcgctg tgtcccttta
      661 acagggagaa gagctgacgt acagcgttga gttccttccg gtgcgtgcaa tagccatgga
      721 ggggtggccc ttgctttgga gttttcaaag ttttccacac accctacccc ctacgcctcc
      781 ggaagtggct atgttccctc tccgttactg gacagccctc aggcgcctgt gctaagttgc
      841 gagtcctggt aaaccgagac tgggtgctgt cctatcatcc tagctggagg ccccaggtcg
      901 ggagaaacgt gctttataat aaagcccgcg catgtgtc
//
LOCUS       NM_001438394            5505 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus centlein (Cntln), transcript variant 1, mRNA.
ACCESSION   NM_001438394
VERSION     NM_001438394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5505)
  AUTHORS   Fang,G., Zhang,D., Yin,H., Zheng,L., Bi,X. and Yuan,L.
  TITLE     Centlein mediates an interaction between C-Nap1 and Cep68 to
            maintain centrosome cohesion
  JOURNAL   J Cell Sci 127 (Pt 8), 1631-1639 (2014)
   PUBMED   24554434
REFERENCE   2  (bases 1 to 5505)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 5505)
  AUTHORS   Makino,K., Umeda,K., Uezu,A., Hiragami,Y., Sakamoto,T., Ihn,H. and
            Nakanishi,H.
  TITLE     Identification and characterization of the novel centrosomal
            protein centlein
  JOURNAL   Biochem Biophys Res Commun 366 (4), 958-962 (2008)
   PUBMED   18086554
  REMARK    GeneRIF: The molecular characterization of a novel protein, named
            centlein (centrosomal protein), is described. Centlein was a
            protein of 721 amino acids with a calculated molecular weight of
            82,717 and possessed coiled-coil domains.[Centlein]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3051864.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000005.1  104342081-104342607
            528-616             JAXUCZ010000005.1  104346801-104346889
            617-701             JAXUCZ010000005.1  104397789-104397873
            702-836             JAXUCZ010000005.1  104408527-104408661
            837-1016            JAXUCZ010000005.1  104409252-104409431
            1017-1150           JAXUCZ010000005.1  104425166-104425299
            1151-1313           JAXUCZ010000005.1  104427394-104427556
            1314-1508           JAXUCZ010000005.1  104437880-104438074
            1509-1661           JAXUCZ010000005.1  104456051-104456203
            1662-1787           JAXUCZ010000005.1  104457803-104457928
            1788-1909           JAXUCZ010000005.1  104465089-104465210
            1910-2029           JAXUCZ010000005.1  104466573-104466692
            2030-2130           JAXUCZ010000005.1  104518465-104518565
            2131-2222           JAXUCZ010000005.1  104523774-104523865
            2223-2755           JAXUCZ010000005.1  104527100-104527632
            2756-2930           JAXUCZ010000005.1  104548135-104548309
            2931-3006           JAXUCZ010000005.1  104552521-104552596
            3007-3230           JAXUCZ010000005.1  104552679-104552902
            3231-3422           JAXUCZ010000005.1  104581424-104581615
            3423-3520           JAXUCZ010000005.1  104585529-104585626
            3521-3647           JAXUCZ010000005.1  104587165-104587291
            3648-3785           JAXUCZ010000005.1  104588297-104588434
            3786-3971           JAXUCZ010000005.1  104588742-104588927
            3972-4157           JAXUCZ010000005.1  104604371-104604556
            4158-4235           JAXUCZ010000005.1  104607964-104608041
            4236-5505           JAXUCZ010000005.1  104621222-104622491
FEATURES             Location/Qualifiers
     source          1..5505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..5505
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="centlein"
                     /db_xref="GeneID:679640"
                     /db_xref="RGD:1308101"
     exon            1..527
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..4337
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein; centlein, centrosomal protein"
                     /codon_start=1
                     /product="centlein isoform 1"
                     /protein_id="NP_001425323.1"
                     /db_xref="GeneID:679640"
                     /db_xref="RGD:1308101"
                     /translation="MAARSPSSSPPSPLARRSSRRALRVGRGAEVHAVRSEASGLAST
                     AREVVADKSDLLWRGKEGSGGRRGSGRPGAALAPVLSAPVGSWWPGGLSSVEAKATRS
                     QLLEEELSSVKEELAQCQADKEFVWSLWKRLQATNPDLTQTVSLVVEREKQKSEAKDR
                     KVLEILQVKDAKIQELEQTEAVLNRELYDLVKLKTLVDEENAFLKKEFSDLQKKFKDK
                     SQEAKDAKECVQSKEEQNRLLIKNLEEENERVRARCTDLLNDLEKLRMQEAHWREEKH
                     SADAKVKVLEENLIEAKKEIESSQSRYNAVSLQLNSKQTELLQKDMDITLVRKELQEL
                     QNLYKQNSAHTAQQADLIQQLQVLNMDTQKVLRNQEDAHTAESITYQELYNELHICFE
                     TTKSNEAMLQQRVANLQHQLFQKEQENVKLKEKLQESQGTLGLSPHESDSNHSAKAPL
                     SSLETLMISQKSEIEYLQKKLKVANEKLMENRSCDQELSEKGTEGKRTEPPVKRSRSL
                     SPKSCFMDSEELRKLKKAERKIQNLEKTLQLKSQENDELRDAHEKRKERLQMLHTNYK
                     AVREQLKQWEEDSGMTETRKPKRADPQQLRREDSDAVWNELAYFKRENQELMVQKMNL
                     QDELDELKIYMTIDKTTIQELNRCMAEKREEQLFRHHEDAGVKKSTPEKNEKAISEQT
                     LEKVIELENRLKSFEKNSRKLKEESKKLKKENDFLKSHLQHYQEDSESRGKELEKLLR
                     VSSSVEQDKSELQTKVTALEREVTTLRRQVAKAKALRDENEEVVNPEEKEHCPTDKAK
                     SEMATTDVRAQHCDCKTTTTKVKFKAAKKKCSVGRHHTVLNHSVKVMSHVENLSKDGW
                     EDMSEGSSDSETQTFQNLGTVIVETSQNIRPIENDGNQKETDQTEDSRAQQEVQTYSC
                     EDLKAPQNTKKMTFQNKSGSLQKNLHSALPARVNREKCKTKPAQKSSSNTILLRERIV
                     SLQQQNSLLQNARKAAESSAKEFKEANEKLLHQQQISDHRFQTSRQTIKKLTLDLAEL
                     RKEKEDLLKKVESSSDITSLAEEVSRIMAPQIQVTTLGPSRSTDLEIKQLQCKLKNAT
                     NELTKQSSSVKSLKLELLAKDDHMKAMQEKMSRMERDITMKRHLIEDLKFRQKINSES
                     NESFNEMLGTLEKKVKTLTEECSNKKVSVDSLKQRLSVAVKEKSQYEQMYQKSKEELE
                     KKDLKMNLLISKLNDTETAMAQIKSAASEQLQGLALQSEQVLEGTQKKLLLANEKIEE
                     FTVFVQALVNELQSDAHRTRQQVRELRQTQKSRHACKTSTHKAQTLAASILNISRSDL
                     EEILHTGDEMEIEKTKIDAENDKDWMLYIQKLLQGQLPFASYLLEAVLGKIKENKKLT
                     EGYFTVMKDIK"
     misc_feature    612..>2501
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    612..>2501
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1731..4037
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1731..4037
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     exon            528..616
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            617..701
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            702..836
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1016
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1150
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1313
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1508
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1661
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1787
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1909
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2029
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2130
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2222
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2755
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2930
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3006
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3230
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3422
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3520
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3647
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3785
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3971
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4157
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4235
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..5505
                     /gene="Cntln"
                     /gene_synonym="RGD1308101"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccgcgct cggagctcgg cccgcgggaa gcggactggg gcccgcgagc gccggacaag
       61 gcgggaaaag ctccgcgcat gcgtatgctg gcaggcccgg ctcctcagga tggggaaggg
      121 aaggtggagt tttcaagcgg gaacttgacc cgttaggcgc cgcggctatg gcggcgcgct
      181 cgccgtcgtc ctcaccgcct tcgcccctgg cgcggcggtc cagccgccgg gccctgcgcg
      241 tcgggcgtgg agccgaggtg cacgctgtgc gcagcgaggc ctcgggtctg gcgagcaccg
      301 cgagggaggt cgtcgcggat aaaagcgact tactctggag gggcaaagaa gggtcagggg
      361 gccggcgagg gtccgggcgg cccggggccg ctctcgctcc agtcctcagc gcgcctgtgg
      421 ggtcctggtg gccagggggc ctctcctcgg tggaggcgaa ggcaacgcga tcgcagctgc
      481 tggaggaaga gctgagcagc gtaaaggagg agctggccca gtgtcaggct gacaaagaat
      541 tcgtatggtc tctgtggaaa cgtcttcagg caacaaaccc agatctcact caaactgtca
      601 gtttggttgt ggaaagagaa aaacagaaat ctgaagccaa agacagaaaa gttctggaaa
      661 ttttacaagt caaagatgcg aaaatacaag aattggagca gactgaagca gtactaaacc
      721 gggagctata tgaccttgta aagctgaaga cgctggttga tgaagaaaat gctttcttga
      781 agaaagaatt cagtgattta cagaagaaat ttaaagataa aagccaagaa gctaaggacg
      841 ccaaggagtg tgtacagagt aaagaagagc aaaacagatt gcttataaaa aacctggagg
      901 aggaaaacga gagggtccgt gcacgctgca ctgacctgct aaatgacctg gagaaactga
      961 ggatgcagga ggcacactgg agggaagaaa agcacagtgc ggatgcgaaa gtaaaggtcc
     1021 ttgaagaaaa tttgattgaa gcaaagaagg aaattgagtc gtcacagagt agatataatg
     1081 ctgtgtcact gcagctgaac agcaaacaga ctgaacttct ccaaaaagat atggacatca
     1141 cactcgtcag gaaggaactg caggagctgc agaatctgta caagcagaac agtgcacaca
     1201 cagcacagca agcagacctg atccagcagc tccaggttct caatatggat acgcagaaag
     1261 tactgaggaa ccaggaagat gctcacacag ctgaaagtat aacataccag gaactttata
     1321 atgaattaca tatttgtttt gaaactacaa aatcaaatga agctatgctc cagcaaagag
     1381 ttgctaatct tcagcatcaa ctgtttcaaa aagaacagga aaatgtaaaa ttaaaagaaa
     1441 aacttcagga atcacaagga acactgggtt tatcaccgca cgagagtgat tcaaaccact
     1501 cagcaaaggc accgttatca agcttggaaa cattaatgat ctcacagaag tctgaaattg
     1561 agtatttaca gaagaagcta aaagtggcaa atgaaaagtt aatggagaat aggtcttgtg
     1621 accaggagct ctcagagaag gggactgaag gaaaacgcac ggagccacct gtgaaacgct
     1681 caaggtcttt gtccccaaag agctgtttca tggactccga ggagctaagg aagcttaaaa
     1741 aggctgaaag aaagattcaa aacttagaga agacactaca gctaaagagc caagaaaatg
     1801 atgagctaag agatgcccat gaaaaacgca aggaaaggct acagatgtta cacaccaact
     1861 acaaagcagt aagagagcaa ttaaaacagt gggaggaaga cagtggcatg actgaaacca
     1921 gaaaaccgaa gcgagcagat cctcaacagc ttcgacgaga agattctgat gctgtgtgga
     1981 atgaactggc atatttcaaa agagaaaacc aggagttgat ggttcaaaag atgaatcttc
     2041 aagatgaatt ggatgagctt aaaatatata tgactattga taaaacaaca atacaggaat
     2101 tgaacagatg catggcagag aaaagagaag aacaactctt tagacaccat gaagatgctg
     2161 gggtcaagaa gagtactcca gagaagaatg agaaagcaat atcggagcag acattagaga
     2221 aggtcattga gttggaaaat cggctaaaat cttttgagaa aaactcaaga aaattaaaag
     2281 aagagagtaa gaaattaaag aaagaaaatg atttcctgaa atcccactta caacactatc
     2341 aagaagactc ggagagcaga ggaaaggagc tagagaaact actgagagtg agcagcagtg
     2401 tagaacagga caaaagtgag cttcaaacaa aagtcactgc tctggagagg gaggtcacta
     2461 cgctgaggag acaagtggca aaagctaagg ctttgagaga tgaaaacgaa gaggtggtga
     2521 atccagagga aaaggaacac tgcccaacag acaaagctaa atctgagatg gccaccacag
     2581 atgtgagagc ccagcactgt gactgcaaga caaccactac caaggtgaaa tttaaagctg
     2641 ccaagaaaaa gtgctctgtg ggtcgccacc acactgttct caatcactcc gtcaaggtta
     2701 tgagccatgt ggagaacctc agcaaggatg gctgggagga catgagtgaa ggcagcagtg
     2761 attctgaaac acaaaccttt caaaatttgg gaacagttat tgtggaaaca tcccagaata
     2821 taaggcctat agaaaatgat ggaaaccaga aggaaactga ccaaacagaa gacagccgtg
     2881 ctcaacaaga agtgcagaca tactcctgtg aggacctcaa ggccccacag aatacgaaga
     2941 aaatgacttt tcaaaacaag agtggaagtc tacagaagaa cttacacagt gcccttcctg
     3001 ccagagttaa cagagaaaag tgcaaaacta aacctgccca gaaatccagt agcaacacta
     3061 ttttattacg agaacggatt gtatccttgc agcaacaaaa cagtttgctt cagaatgcca
     3121 ggaaagcagc agagtcgtct gctaaagaat ttaaagaagc aaatgaaaaa ctcctccatc
     3181 aacagcagat atctgatcac cgattccaga ccagcaggca gacaataaag aagctaactc
     3241 ttgatttagc tgaacttcga aaagagaaag aagatttgtt gaagaaagtg gagtcttcat
     3301 ctgacatcac aagcttggca gaagaagttt ccagaataat ggccccacag atacaagtta
     3361 ccacactggg tccttcaagg agcacggatt tggaaataaa gcaattgcag tgtaaactaa
     3421 agaatgcaac taacgaactc actaagcagt cctcgagtgt gaagtcgctg aagctggaac
     3481 ttctggcgaa ggatgaccac atgaaggcga tgcaggagaa gatgtctcga atggagagag
     3541 atataaccat gaaaagacac ctgattgagg acttgaaatt tcgacagaaa ataaattcag
     3601 aaagtaatga gagttttaat gaaatgttag gaactcttga aaaaaaggta aagacattaa
     3661 ctgaagaatg ttccaacaag aaggtatcag ttgattcact aaagcaaaga cttagcgttg
     3721 ctgtgaaaga gaaatcacag tatgaacaga tgtatcagaa aagtaaagag gagttagaaa
     3781 aaaaggatct caagatgaat ctcctgatat caaaactaaa tgacacggag acagccatgg
     3841 ctcagatcaa gagcgcagcg tcggagcagc tccaaggctt ggcgttgcag agtgagcagg
     3901 tcctggaagg cacgcagaag aaactgctgc tggccaatga aaagatcgag gagttcactg
     3961 tctttgtgca ggctttggtc aatgagttac aaagtgatgc ccataggaca agacaacaag
     4021 tcagagagct taggcagacg cagaaaagca gacatgcttg taaaacctca acccataaag
     4081 cccagacctt ggccgcttcc atcctgaaca tctcacggtc agacctagaa gaaatattgc
     4141 acacaggaga tgaaatggaa atcgagaaga caaagataga tgctgaaaat gacaaggact
     4201 ggatgttgta cattcagaaa cttctccaag gacagcttcc ttttgcatca tatttactag
     4261 aagcagtgct ggggaaaata aaggaaaaca agaagctgac tgaaggatat ttcacagtca
     4321 tgaaagacat taaataaagt tgcagcagac ctgttttcaa atgcaggaac ttggtgtgct
     4381 gcagtggtga acagtgcaga tgctgtaaac agtcactgct tcagcaagca gcgggcagct
     4441 tctacccagc aaaggctgct gagactgacc gctgaaccga tgaagctaac caagtgctcg
     4501 gcctcgccaa agggaagtct agcatttgaa tgctggctgt tatccccaat caatgcaaac
     4561 ttaaaatggt ttccttccag tgcttaagaa aacaaaacaa gcttctcaca ggcaaatggg
     4621 cctgagtata aaatgaaaaa gttataaata aaggacttaa tataaactca tatgaaaact
     4681 agatttttta tataaaacta ttataaatga gatccagtga acaacatctt tacatggtga
     4741 gaaagtatga agtgaattat cctaatgtga aggaggagca ctgagtgaag ccaattgtat
     4801 agctccattg taactattct cattgacaca ctggattata cgggacatac tctgtttttc
     4861 tagaactctc tggataaaca agaacctttt cctcctctgt ctgcttgtgc tgctgtataa
     4921 atcagcaaag accagaaccc cagtgtgtaa tgttgctcta gacctagcag agctcctacc
     4981 acggccatct aattaacaat gccttctcac tgtgatggga gcattgtatg tgattgttac
     5041 caccccctcc ctgcacgtcc tcactgagtt cttgccacac attcttggag cctctgagtc
     5101 actgaacttg gcctctatgt ttgctgttgg ggccatcttt gcagaatact ttgtaactgt
     5161 aggtatgcct gtcttcttat tacccaggct cactttatca gtcctgtcat agcgtatttc
     5221 tgaaaatctt actgttaacc tgaaatcatc tgtttttaat atgctcactc ttcgttttat
     5281 ggttcatcct tatttcctcc tttaaaatgt agatcccatg agattaaggt aggtgttggc
     5341 aaattgaggc ccatagccaa atctagcctg ccacctactt tatagagttc acagactaaa
     5401 catttttcta ttttattaaa ctgtttaaaa acaatacttt gtagcatgta aaaatcatat
     5461 gaaattcaat tttaatgtct tatcaataaa gatttattga gattc
//
LOCUS       NM_001438419            3092 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 7 (Htr7), transcript
            variant 1, mRNA.
ACCESSION   NM_001438419 XM_006231307
VERSION     NM_001438419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Korlatowicz,A., Pabian,P., Solich,J., Kolasa,M., Latocha,K.,
            Dziedzicka-Wasylewska,M. and Faron-Gorecka,A.
  TITLE     Habenula as a Possible Target for Treatment-Resistant Depression
            Phenotype in Wistar Kyoto Rats
  JOURNAL   Mol Neurobiol 60 (2), 643-654 (2023)
   PUBMED   36344870
  REMARK    GeneRIF: Habenula as a Possible Target for Treatment-Resistant
            Depression Phenotype in Wistar Kyoto Rats.
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Slawinska,U., Majczynski,H., Kwasniewska,A., Miazga,K., Cabaj,A.M.,
            Bekisz,M., Jordan,L.M. and Zawadzka,M.
  TITLE     Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar
            Spinal Blockade of 5-HT7 Receptors
  JOURNAL   Int J Mol Sci 22 (11), 6007 (2021)
   PUBMED   34199392
  REMARK    GeneRIF: Unusual Quadrupedal Locomotion in Rat during Recovery from
            Lumbar Spinal Blockade of 5-HT7 Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Cinar,I., Halici,Z., Dincer,B., Sirin,B. and Cadirci,E.
  TITLE     The role of 5-HT7 receptors on isoproterenol-induced myocardial
            infarction in rats with high-fat diet exacerbated coronary
            endothelial dysfunction
  JOURNAL   Hum Exp Toxicol 39 (8), 1005-1018 (2020)
   PUBMED   32329363
  REMARK    GeneRIF: The role of 5-HT7 receptors on isoproterenol-induced
            myocardial infarction in rats with high-fat diet exacerbated
            coronary endothelial dysfunction.
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Hernandez-Abreu,O.I., Garcia-Pedraza,J.A., Rivera-Mancilla,E.,
            Villanueva-Castillo,B., Moran,A., Garcia-Domingo,M.,
            Manrique-Maldonado,G., Altamirano-Espinoza,A.H. and Villalon,C.M.
  TITLE     Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7
            receptors inhibiting the tachycardic sympathetic drive in pithed
            rats
  JOURNAL   Clin Exp Pharmacol Physiol 47 (3), 403-411 (2020)
   PUBMED   31846086
  REMARK    GeneRIF: Blockade of 5-HT2 receptors with sarpogrelate uncovers
            5-HT7 receptors inhibiting the tachycardic sympathetic drive in
            pithed rats.
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Seitz,B.M., Demireva,E.Y., Xie,H., Fink,G.D., Krieger-Burke,T.,
            Burke,W.M. and Watts,S.W.
  TITLE     5-HT does not lower blood pressure in the 5-HT7 knockout rat
  JOURNAL   Physiol Genomics 51 (7), 302-310 (2019)
   PUBMED   31125292
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Ruat,M., Traiffort,E., Leurs,R., Tardivel-Lacombe,J., Diaz,J.,
            Arrang,J.M. and Schwartz,J.C.
  TITLE     Molecular cloning, characterization, and localization of a
            high-affinity serotonin receptor (5-HT7) activating cAMP formation
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8547-8551 (1993)
   PUBMED   8397408
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Shen,Y., Monsma,F.J. Jr., Metcalf,M.A., Jose,P.A., Hamblin,M.W. and
            Sibley,D.R.
  TITLE     Molecular cloning and expression of a 5-hydroxytryptamine7
            serotonin receptor subtype
  JOURNAL   J Biol Chem 268 (24), 18200-18204 (1993)
   PUBMED   8394362
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Meyerhof,W., Obermuller,F., Fehr,S. and Richter,D.
  TITLE     A novel rat serotonin receptor: primary structure, pharmacology,
            and expression pattern in distinct brain regions
  JOURNAL   DNA Cell Biol 12 (5), 401-409 (1993)
   PUBMED   8517926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006231307.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69663.1, SRR26360176.274686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               JAXUCZ010000001.1  243172386-243173048 c
            664-1419            JAXUCZ010000001.1  243059694-243060449 c
            1420-3092           JAXUCZ010000001.1  243049064-243050736 c
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..3092
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="5-hydroxytryptamine receptor 7"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
     exon            1..663
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    41..43
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="upstream in-frame stop codon"
     CDS             116..1462
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serotonin receptor 7; GPRFO; 5-HT-7; 5-HT-X; 5-HT7; high
                     affinity serotonin receptor (5HT7); 5-hydroxytryptamine
                     (serotonin) receptor 7, adenylate cyclase-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 7 isoform 1"
                     /protein_id="NP_001425348.1"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
                     /translation="MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSW
                     MPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGN
                     CLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV
                     FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL
                     PPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH
                     KFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGI
                     IVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNR
                     DLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT"
     misc_feature    128..130
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2); glycosylation site"
     misc_feature    320..322
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2); glycosylation site"
     misc_feature    374..448
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    413..1309
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_5-HT7; cd15329"
                     /db_xref="CDD:320452"
     misc_feature    413..1309
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     Region: 7tmA_5-HT7; cd15329"
                     /db_xref="CDD:320452"
     misc_feature    470..550
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320452"
     misc_feature    470..550
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320452"
     misc_feature    479..544
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    581..658
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    587..679
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320452"
     misc_feature    587..679
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320452"
     misc_feature    order(596..601,608..613,620..625,815..817,851..853,
                     863..865,1142..1144,1151..1156,1172..1174,1211..1213,
                     1220..1225,1232..1234,1244..1246)
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320452"
     misc_feature    order(596..601,608..613,620..625,815..817,851..853,
                     863..865,1142..1144,1151..1156,1172..1174,1211..1213,
                     1220..1225,1232..1234,1244..1246)
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320452"
     misc_feature    713..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320452"
     misc_feature    713..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320452"
     misc_feature    719..781
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    830..919
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320452"
     misc_feature    830..919
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320452"
     misc_feature    836..904
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    1082..1174
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320452"
     misc_feature    1082..1174
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320452"
     misc_feature    1103..1180
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     misc_feature    1211..1288
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320452"
     misc_feature    1211..1288
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320452"
     misc_feature    1214..1285
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2);
                     transmembrane region"
     exon            664..1419
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..3092
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccccatg gctgggccgc gcggagccga gcgggcaagg tgaatccagc cccggggccg
       61 gctgccggag cgcttggcgg ggtcgccggc tccatgggca gcggcgctcg gcacgatgat
      121 ggacgttaac agcagcggcc gccccgacct ctacggccat ctccgttcac tcatcctgcc
      181 ggaggtgggg cgcgggctgc aggacctgag ccccgacggt ggcgcccacc ctgtggtgag
      241 ctcctggatg ccgcacctgc tgagtggctt cctagaggtg acggctagcc cggcgcccac
      301 ctgggacgcg ccaccggaca atgtctcagg ctgcggggag cagatcaact atggcagagt
      361 ggagaaagtt gtgatcggct ccatcctgac gctcatcacg ctgctgacga tcgcaggcaa
      421 ctgcctggtg gtgatctcgg tgtgcttcgt caagaagctc cgccagccct ccaactacct
      481 gattgtgtcc ctggcgctgg ctgacctctc ggtggccgtg gcggtcatgc ctttcgttag
      541 tgtcaccgac ctcatcgggg gcaagtggat cttcggccac ttcttctgca acgtcttcat
      601 cgccatggac gtcatgtgct gcacggcctc gatcatgacc ctgtgcgtga tcagcatcga
      661 caggtacctt gggatcacga gacccctcac gtacccggtg aggcaaaatg ggaaatgtat
      721 ggccaaaatg attctgtcgg tctggctgct ctctgcctcc atcaccttac ctcctctctt
      781 cggatgggct cagaatgtga acgatgacaa agtgtgcttg atcagccagg attttggcta
      841 cacgatctac tccactgcgg tggcgtttta tatccccatg tcggtcatgc tgttcatgta
      901 ctatcagatt tacaaggccg ccaggaagag tgcagccaaa cacaagttcc caggcttccc
      961 acgcgtgcag ccggagagtg tcatctccct gaatggtgtg gtgaagctcc agaaggaggt
     1021 ggaagagtgt gcgaaccttt cgagactgct caaacacgaa aggaaaaaca tctccatctt
     1081 caagcgggaa cagaaagcag ccactacctt ggggatcatc gtgggagcct tcactgtgtg
     1141 ctggctgccg tttttcctct tgtccacagc ccgccccttt atctgtggca cctcctgtag
     1201 ctgcattcct ctgtgggtgg agaggacatg tctgtggctg ggctatgcaa actctctcat
     1261 taatcctttt atatatgcct tcttcaaccg ggacctgagg accacctatc gtagcctact
     1321 ccagtgccag taccggaata tcaaccggaa gctctctgct gcaggcatgc atgaagccct
     1381 gaaacttgct gagaggcccg agagatccga gtttgtgcta caaaactctg accactgtgg
     1441 gaaaaagggt catgatacat gatccagagt ggaaccctgg atgaattcat gcagaacagg
     1501 tggacacaac acaacgaaat cattggctga gactgcacaa tggaacatgg cttctgtctt
     1561 cttggcatgg cttgaaatgt cacgaggggt gatctgttgt acaaagtgta tcatggggag
     1621 atggcaacct ctcccttttt tcctgtggat cagtgatatt gtgtttaaat gaaaatagtg
     1681 ctcagtgtca gacagccagt catctctgca gtaagcacac tacagagctg ggtttcggga
     1741 ggggagggaa gcagtttctg gtgctttcca caagtccaca tccacaagag tggggggaaa
     1801 tcctaacgca caattcccat gcttccagtc taggctttgt ggtaactctt caggaaccat
     1861 tcatgagaca gagtacattt tgtggtatga cagaagggtg tcttttcaag caagctacag
     1921 taagcattgt gctgaacgtg ttgcatgtcc gtgttagaaa acagaaaccc agtcatcagc
     1981 taattcaagc aattccccag agcagtgttt gttcaaagct tctgttaaat attgtggctt
     2041 tcctgcaggg tccttgtgac tttccaccag tgtgtgtcca ctgtcaaatc ctttatcatt
     2101 atggtgtaac tcaggaacag atctcaggtt ggagagaggc agaaaacctg aatcaagctt
     2161 ttccttgcac tcacacttct gaaggctcct gagagaggac ggtaactgga gatgagtgag
     2221 tgccacctca ccgcattgta tattaacatg attctcggca tgttgttcac tcccatcttc
     2281 cacaagggtg caaggagccc acagggctgg tccatgactg tgtgttatga ggagagagtg
     2341 tgacaatagc aaatccatga atagttgcgg ttgtttctgg agacagcgta aacatggtca
     2401 cccaactgga ctgtttgaat cgtgtgagct agcggccact tgaaccccca ttgttaatac
     2461 tctagaacac cgttctgttt catgtagaga atttgtttct gtgttctctg tatcttaaat
     2521 caaatgtgtg cctgatgaat tctgtcctct aaccccctcc caccaataaa aatggtcaat
     2581 gttaaggaca ggtaaggaag cagaaagggt tcctttgtgg atagtatcct ttaaatgttg
     2641 ctatgtagta gtctgggtga aggagatgga aagccacagt tcagaagagt acccgtgtct
     2701 ataaggggga catgaatgaa aacctttatt tgaaaaaagg gaactgaaaa agaatattat
     2761 tttcctacaa ttaagaaggc tgtcctctca cagaataaaa tagagttcca aagtgtatta
     2821 tgaacttctt ccagatgtca ctgatgtcta ttatgaaagc agggaagggc ccctttcctg
     2881 tgaaggggag gcaggcactg tcctttcaga atgtgtacaa attcctgagc tgcagttttg
     2941 ctagactgac catatatact tatattccta atttaaataa caattatgtc agatatgtgt
     3001 tgttaaattt gaaagtgttt tattacatta catcgaaata aaggttattt gtagctgtaa
     3061 taaagcaact taagcaacgt ttttaataaa aa
//
LOCUS       NM_001438428            4602 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus adaptor related protein complex 2 subunit alpha 2
            (Ap2a2), transcript variant 1, mRNA.
ACCESSION   NM_001438428 XM_008760010
VERSION     NM_001438428.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4602)
  AUTHORS   Capella,P., Asensio,J., Troncoso,M., Sosa,M.A. and Seltzer,A.M.
  TITLE     Evidence on differential role for alpha 1 and alpha 2 subtypes of
            AP-2 adaptin in the central nervous system
  JOURNAL   Neurosci Lett 808, 137282 (2023)
   PUBMED   37127089
  REMARK    GeneRIF: Evidence on differential role for alpha 1 and alpha 2
            subtypes of AP-2 adaptin in the central nervous system.
REFERENCE   2  (bases 1 to 4602)
  AUTHORS   Taoufiq,Z., Ninov,M., Villar-Briones,A., Wang,H.Y., Sasaki,T.,
            Roy,M.C., Beauchain,F., Mori,Y., Yoshida,T., Takamori,S., Jahn,R.
            and Takahashi,T.
  TITLE     Hidden proteome of synaptic vesicles in the mammalian brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (52), 33586-33596 (2020)
   PUBMED   33376223
REFERENCE   3  (bases 1 to 4602)
  AUTHORS   Marcello,E., Saraceno,C., Musardo,S., Vara,H., de la Fuente,A.G.,
            Pelucchi,S., Di Marino,D., Borroni,B., Tramontano,A.,
            Perez-Otano,I., Padovani,A., Giustetto,M., Gardoni,F. and Di
            Luca,M.
  TITLE     Endocytosis of synaptic ADAM10 in neuronal plasticity and
            Alzheimer's disease
  JOURNAL   J Clin Invest 123 (6), 2523-2538 (2013)
   PUBMED   23676497
REFERENCE   4  (bases 1 to 4602)
  AUTHORS   Duncker,S.V., Franz,C., Kuhn,S., Schulte,U., Campanelli,D.,
            Brandt,N., Hirt,B., Fakler,B., Blin,N., Ruth,P., Engel,J.,
            Marcotti,W., Zimmermann,U. and Knipper,M.
  TITLE     Otoferlin couples to clathrin-mediated endocytosis in mature
            cochlear inner hair cells
  JOURNAL   J Neurosci 33 (22), 9508-9519 (2013)
   PUBMED   23719817
REFERENCE   5  (bases 1 to 4602)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4602)
  AUTHORS   Takei,K., Mundigl,O., Daniell,L. and De Camilli,P.
  TITLE     The synaptic vesicle cycle: a single vesicle budding step involving
            clathrin and dynamin
  JOURNAL   J Cell Biol 133 (6), 1237-1250 (1996)
   PUBMED   8682861
REFERENCE   7  (bases 1 to 4602)
  AUTHORS   Voglmaier,S.M., Keen,J.H., Murphy,J.E., Ferris,C.D.,
            Prestwich,G.D., Snyder,S.H. and Theibert,A.B.
  TITLE     Inositol hexakisphosphate receptor identified as the clathrin
            assembly protein AP-2
  JOURNAL   Biochem Biophys Res Commun 187 (1), 158-163 (1992)
   PUBMED   1325787
REFERENCE   8  (bases 1 to 4602)
  AUTHORS   Bahler,M., Klein,R.L., Wang,J.K., Benfenati,F. and Greengard,P.
  TITLE     A novel synaptic vesicle-associated phosphoprotein: SVAPP-120
  JOURNAL   J Neurochem 57 (2), 423-430 (1991)
   PUBMED   2072093
  REMARK    Erratum:[J Neurochem 1991 Dec;57(6):2155]
REFERENCE   9  (bases 1 to 4602)
  AUTHORS   Tucker,K.L., Nathanson,K. and Kirchhausen,T.
  TITLE     Sequence of the rat alpha c large chain of the clathrin associated
            protein complex AP-2
  JOURNAL   Nucleic Acids Res 18 (17), 5306 (1990)
   PUBMED   2402467
REFERENCE   10 (bases 1 to 4602)
  AUTHORS   Kirchhausen,T., Nathanson,K.L., Matsui,W., Vaisberg,A., Chow,E.P.,
            Burne,C., Keen,J.H. and Davis,A.E.
  TITLE     Structural and functional division into two domains of the large
            (100- to 115-kDa) chains of the clathrin-associated protein complex
            AP-2
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2612-2616 (1989)
   PUBMED   2495531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_008760010.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.4146.1,
                                           SRR26643299.5110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000001.1  206081886-206082075
            191-259             JAXUCZ010000001.1  206110540-206110608
            260-402             JAXUCZ010000001.1  206122048-206122190
            403-596             JAXUCZ010000001.1  206123371-206123564
            597-726             JAXUCZ010000001.1  206126691-206126820
            727-828             JAXUCZ010000001.1  206129200-206129301
            829-937             JAXUCZ010000001.1  206133896-206134004
            938-1085            JAXUCZ010000001.1  206135412-206135559
            1086-1254           JAXUCZ010000001.1  206136668-206136836
            1255-1392           JAXUCZ010000001.1  206138182-206138319
            1393-1575           JAXUCZ010000001.1  206142657-206142839
            1576-1673           JAXUCZ010000001.1  206143286-206143383
            1674-1905           JAXUCZ010000001.1  206143617-206143848
            1906-2079           JAXUCZ010000001.1  206143939-206144112
            2080-2243           JAXUCZ010000001.1  206146543-206146706
            2244-2326           JAXUCZ010000001.1  206148953-206149035
            2327-2416           JAXUCZ010000001.1  206150081-206150170
            2417-2540           JAXUCZ010000001.1  206151363-206151486
            2541-2657           JAXUCZ010000001.1  206152233-206152349
            2658-2727           JAXUCZ010000001.1  206152458-206152527
            2728-2862           JAXUCZ010000001.1  206152617-206152751
            2863-4602           JAXUCZ010000001.1  206153413-206155152
FEATURES             Location/Qualifiers
     source          1..4602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4602
                     /gene="Ap2a2"
                     /note="adaptor related protein complex 2 subunit alpha 2"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
     exon            1..190
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    34..36
                     /gene="Ap2a2"
                     /note="upstream in-frame stop codon"
     CDS             124..2940
                     /gene="Ap2a2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adaptor protein complex AP-2, alpha 2 subunit; AP-2
                     complex subunit alpha-2; alpha2-adaptin; alpha-adaptin C;
                     100 kDa coated vesicle protein C; adaptor protein complex
                     AP-2 subunit alpha-2; adaptor-related protein complex 2,
                     alpha 2 subunit; adapter-related protein complex 2 alpha-2
                     subunit; clathrin assembly protein complex 2 alpha-C large
                     chain; plasma membrane adaptor HA2/AP2 adaptin alpha C
                     subunit; adapter-related protein complex 2 subunit
                     alpha-2"
                     /codon_start=1
                     /product="AP-2 complex subunit alpha-2 isoform 1"
                     /protein_id="NP_001425357.1"
                     /db_xref="GeneID:81637"
                     /db_xref="RGD:71015"
                     /translation="MPAVSKGEGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKF
                     KGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLV
                     NSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDT
                     MDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKN
                     PEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVR
                     GRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLG
                     QFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLL
                     YAMCDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIR
                     IAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGN
                     LIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKATIQDVLRSDS
                     QLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTV
                     TDLEETKRERSIDVNGGPEPVPASTSAASTPSPSADLLGLGAVPPAPTGPPPTSGGGL
                     LVDVFSDSASAVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIF
                     YGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGGAQVQQVVNIECISDFTEA
                     PVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKA
                     KHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQM
                     YRLTLRTSKDTVSQRLCELLSEQF"
     misc_feature    208..1893
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    208..1893
                     /gene="Ap2a2"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    1114..1185
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1114..1185
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1225..1314
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1225..1314
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1342..1422
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1342..1422
                     /gene="Ap2a2"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    1966..2166
                     /gene="Ap2a2"
                     /note="propagated from UniProtKB/Swiss-Prot (P18484.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2269..2580
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2269..2580
                     /gene="Ap2a2"
                     /note="Adaptin C-terminal domain; Region: Alpha_adaptinC2;
                     smart00809"
                     /db_xref="CDD:197886"
     misc_feature    2596..2922
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     misc_feature    2596..2922
                     /gene="Ap2a2"
                     /note="Alpha adaptin AP2, C-terminal domain; Region:
                     Alpha_adaptin_C; pfam02296"
                     /db_xref="CDD:426707"
     exon            191..259
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            260..402
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..596
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..726
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..828
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..937
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1085
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1254
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1392
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1575
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1673
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1905
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2079
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2243
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2326
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2416
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2540
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2657
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2727
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2862
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..4602
                     /gene="Ap2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggcgct cgggggcccg aggcggctgt ggctaggcgg ctccgcgctc cagggctact
       61 cggcgtgacg gccgcgcccg ttctgttcca gcccgccgcc gaggccgctc ccgggtcgca
      121 aagatgccgg ccgtatccaa gggggagggg atgcgaggcc tagcggtctt catctccgat
      181 atccgtaact gtaaaagtaa agaagctgaa ataaagagga taaataagga gctggcaaat
      241 attagatcaa aatttaaagg tgacaaggct cttgatggct acagtaagaa gaagtatgtc
      301 tgcaagttac tcttcatctt tctccttggt catgacattg actttggaca catggaagct
      361 gtgaatcttc tgagctcaaa cagatacacg gaaaagcaga tcggctacct tttcatctct
      421 gtattggtga attcaaatag tgaactgatc cggttgatta acaatgccat caagaatgac
      481 ctggccagcc gcaatcctac atttatgggt ctggccctgc actgcatcgc caatgtgggt
      541 agccgtgaga tggcagaggc cttcgctgga gagatcccca agatcctggt ggcaggagat
      601 accatggaca gtgtgaagca gagcgcagcc ctgtgcttgt tgcgcctgta caggacgtca
      661 cctgacctag ttcctatggg cgactggaca tcccgtgtgg tacacctcct caatgaccag
      721 cacttgggtg tagtgactgc cgcaactagc ctcatcacca cactggccca gaagaatcct
      781 gaggagttca agacctctgt ctctctagct gtctctcgac tgagcagaat tgtgacgtcc
      841 gcgtcaacag atcttcagga ttatacttac tactttgtcc cggctccttg gctgtcagtc
      901 aaacttctga gactgctgca gtgctaccca cccccagacc ctgcggtgcg tggccgcctg
      961 actgagtgct tggagaccat cctgaataag gcccaggagc cccccaagtc caagaaagtc
     1021 cagcattcaa atgccaagaa cgctgtgctg tttgaggcca tcagcctcat catccaccat
     1081 gacagtgagc ccaacctcct ggtccgtgcc tgcaaccagc tgggccagtt cctgcagcat
     1141 cgggagacaa acctgcgcta cctggctctg gagagcatgt gcacactggc cagctctgag
     1201 ttctctcacg aggctgtcaa gacccacatc gagactgtca tcaatgcctt gaagacggaa
     1261 cgagatgtga gtgtgcggca gcgggcagtg gacctgctct acgccatgtg cgaccgaagc
     1321 aacgcccagc agattgtggc tgagatgctg agctacctag aaacagctga ctactccatc
     1381 cgggaggaaa ttgtgctgaa ggtggccatc cttgctgaga agtatgcagt ggactacact
     1441 tggtatgtgg acaccatcct caacctcatc cgcattgcag gcgactatgt gagcgaagag
     1501 gtgtggtacc gcgtcatcca gattgtcatc aatcgcgatg atgtgcaggg ttatgctgcc
     1561 aagacggtgt ttgaggcatt gcaggctcca gcatgtcatg agaacttggt caaagtgggc
     1621 ggctacatcc tgggcgagtt tggaaacttg atagcgggag acccacgatc cagccctctg
     1681 atccagttca acctgctcca ctccaagttc cacttgtgca gcgtccccac tcgggcactc
     1741 ctgctgtcca cctacatcaa gttcgtgaac ctctttccag aggtaaaggc taccattcag
     1801 gacgtgctgc gcagtgacag ccaactgaag aacgcagatg tggagctgca gcagcgggct
     1861 gtggagtacc tgcgactgag tactgttgcc agcactgata tcctggcaac tgtcctggaa
     1921 gaaatgccac ccttccctga gcgtgagtcc tccatcttgg ccaagctgaa gaagaagaag
     1981 ggcccaagca cagtgactga cctggaggag accaagcgtg agcgaagcat cgatgtgaat
     2041 gggggccccg aacccgttcc agccagcacc agtgctgcgt ccacaccttc tccatcagca
     2101 gacctgctgg gtctgggggc cgttccccct gctcccacag ggccccctcc cacctctggc
     2161 ggtgggttac tggtggacgt gttctcagac tcagcttctg cagttgcacc tcttgcaccc
     2221 ggctctgaag acaactttgc caggtttgtt tgtaaaaaca atggtgtgtt gtttgaaaac
     2281 cagctgcttc aaattggact gaagtcagaa tttcggcaga atttaggtcg aatgttcata
     2341 ttttatggta acaagacctc cacgcagttc ctaaacttca ctccaacact aatctgtgct
     2401 gacgaccttc agactaatct gaacctgcag actaagcccg tggacccaac tgtggatggg
     2461 ggcgcacagg tgcaacaggt ggtcaacatt gagtgtatat ctgatttcac agaggcacct
     2521 gtcctcaaca tccagttcag gtatggtggt accttccaga atgtgtctgt taagcttccc
     2581 atcactctca acaaattttt ccagcccaca gaaatggctt ctcaggattt ctttcaacgt
     2641 tggaagcagt tgagcaatcc acagcaagaa gtgcagaata tcttcaaagc aaagcatccg
     2701 atggacacag aaatcactaa agcgaagatt attggatttg gttctgcgct cctggaagaa
     2761 gttgatccaa accctgcaaa ttttgtgggt gctggcataa tacataccaa aaccacccag
     2821 atcggctgct tgttgcgcct ggagccaaac ctgcaagctc agatgtacag actcaccttg
     2881 cgtaccagca aagacaccgt ctctcagaga ctatgtgaat tgctgtcgga acagttctaa
     2941 tccacagacc agaagatcag gctctttgtt tgtgcgtctc tctcgtctct ctcgtttgtc
     3001 tttgtaccac actgcagata aacacccctt gtctgaaaac tgccattcaa ggcacctcca
     3061 gtcctacacc tacagccagc ccctgggtgt ggagggaatg caggacacag tttgagaagg
     3121 gctgcagcag gcctgccccg tcaaagaagg gtgcctgggc ctgggaaatc aaggcagtcc
     3181 tgtggttcaa cctacaaatt aaagggaaat tagaaatttg aacgaaagtg gaaattttgt
     3241 tcaaatttta ttaaaatgcc actggttcaa tctcagaatc cagaaatagc gccatgtgct
     3301 tatagggtta acacagggct gtgtgaccat gctggatggt gagggcagtg gcttagaggt
     3361 gtgtgacctc aagggccggg cagtgtccat ggagtttgct gcagcactgc ctgacggtgc
     3421 tgaagtgctt gtgcttataa ctgttggcaa actccatgcc cactcgtggc agggccctgt
     3481 gcctaacaag ccagtgttct tgaagggaca gtctgaacat ttcaccactt ttttgagatc
     3541 ctagttttgc agcatggtgg gcaaagggct tcctcttgac tttggaagac atggatgtca
     3601 cccatctttt gtttttatga atgtactgtc cctatggtac cttctgggga cctgaaggct
     3661 atgtgggtgg ggtgatgagg taatgactgt gagacacgct tctctccaga gggtcttggt
     3721 tggtgcccag tgctctgtcc tcacttctgt gaagcccttg tggttgggtg ggaaagagag
     3781 acctaaatgt ggcaatggag tgacaggctg gagcgagaat ggcagcccag gcaggtgctg
     3841 cactaaggat gcactgggct tcctagctca cgggccagtt aaccctttgt gggcattgga
     3901 ctgtatgtac agcccatcag gggaagagca taggccacat cagcagctca ggcttgggac
     3961 cttgcactct gtcttgaggt gatgcccagg actgctacag actcagctgt atagggtcag
     4021 cggtacttac acagcagtgt tgatgtccct tgcccactgc agcactaggg gtggtcactt
     4081 aaatgaggat gttttttgcc tcagcctcag gctgctagcc tgtcatggtg ggtttgaggg
     4141 ctgcagcagg gctccagcct actcaggctc ccgtagcccc actctgtcca gcccaggcag
     4201 ttagtcagaa caaccaacac ctgtgtgctg atcagtgcat tccacaaagc ccttggtctg
     4261 cctgtcatgt tgtgacccac gcctgccatg gcacaggctt cttctgttcc agatggatga
     4321 cctagctgtg gtcacagtga gcctcccaag tccccttgct ctagtagctg gacagtgtgg
     4381 ctgtccatta tgtacagtcc acgcactatt gcatggaccg tgtggatagc tcaacctgtg
     4441 taccatgtgc tgcccagtga tggtgtctcg atcagtaacg tcccagcaca cggaagctgc
     4501 tggggcatag gcccgccctc catgactacc gggcctccat tagtccagtg tgcttgttct
     4561 cagagaaaaa aaaaaaataa atgctaggac aggaaactgg aa
//
LOCUS       NM_001438358            1266 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus vascular endothelial growth factor B (Vegfb),
            transcript variant 1, mRNA.
ACCESSION   NM_001438358 XM_006230912
VERSION     NM_001438358.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Tu,S., Wang,X.Y., Zeng,L.X., Shen,Z.J. and Zhang,Z.H.
  TITLE     LncRNA TINCR improves cardiac hypertrophy by regulating the
            miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway
  JOURNAL   Lab Invest 102 (3), 253-262 (2022)
   PUBMED   34732848
  REMARK    GeneRIF: LncRNA TINCR improves cardiac hypertrophy by regulating
            the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway.
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Shang,R., Lal,N., Lee,C.S., Zhai,Y., Puri,K., Seira,O.,
            Boushel,R.C., Sultan,I., Rasanen,M., Alitalo,K., Hussein,B. and
            Rodrigues,B.
  TITLE     Cardiac-specific VEGFB overexpression reduces lipoprotein lipase
            activity and improves insulin action in rat heart
  JOURNAL   Am J Physiol Endocrinol Metab 321 (6), E753-E765 (2021)
   PUBMED   34747201
  REMARK    GeneRIF: Cardiac-specific VEGFB overexpression reduces lipoprotein
            lipase activity and improves insulin action in rat heart.
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Lal,N., Chiu,A.P., Wang,F., Zhang,D., Jia,J., Wan,A., Vlodavsky,I.,
            Hussein,B. and Rodrigues,B.
  TITLE     Loss of VEGFB and its signaling in the diabetic heart is associated
            with increased cell death signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (6), H1163-H1175 (2017)
   PUBMED   28314760
  REMARK    GeneRIF: Loss of VEGFB and its downstream signaling is an early
            event following hyperglycemia, is sustained with disease
            progression, and could explain diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Monastero,R., Garcia-Serrano,S., Lago-Sampedro,A.,
            Rodriguez-Pacheco,F., Colomo,N., Morcillo,S., Martin-Nunez,G.M.,
            Gomez-Zumaquero,J.M., Garcia-Fuentes,E., Soriguer,F.,
            Rojo-Martinez,G. and Garcia-Escobar,E.
  TITLE     Methylation patterns of Vegfb promoter are associated with gene and
            protein expression levels: the effects of dietary fatty acids
  JOURNAL   Eur J Nutr 56 (2), 715-726 (2017)
   PUBMED   26707994
  REMARK    GeneRIF: Data suggest that dietary fatty acids create
            epigenetic/nutrigenomic changes in methylation levels of CpG island
            at Vegfb promoter and changes in Vegfb expression in white
            adipocytes in vivo and in vitro, with particular up-regulation of
            DNA methylation by linoleic acid; Vegfb promoter methylation levels
            are closely related to Vegfb gene expression in visceral and
            subcutaneous adipose tissue.
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Rintala,J.M., Savikko,J., Palin,N., Rintala,S.E., Koskinen,P.K. and
            von Willebrand,E.
  TITLE     Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth
            Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in
            Experimental Kidney Transplantation Model
  JOURNAL   Transplantation 100 (1), 103-110 (2016)
   PUBMED   26262503
  REMARK    GeneRIF: Combined inhibition of PGDF and VEGF with sunitinib
            prevents chronic rejection changes in experimental kidney
            transplantation.
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Nag,S., Eskandarian,M.R., Davis,J. and Eubanks,J.H.
  TITLE     Differential expression of vascular endothelial growth factor-A
            (VEGF-A) and VEGF-B after brain injury
  JOURNAL   J Neuropathol Exp Neurol 61 (9), 778-788 (2002)
   PUBMED   12230324
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Ikuta,T., Ariga,H. and Matsumoto,K.
  TITLE     Extracellular matrix tenascin-X in combination with vascular
            endothelial growth factor B enhances endothelial cell proliferation
  JOURNAL   Genes Cells 5 (11), 913-927 (2000)
   PUBMED   11122379
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Bellomo,D., Headrick,J.P., Silins,G.U., Paterson,C.A., Thomas,P.S.,
            Gartside,M., Mould,A., Cahill,M.M., Tonks,I.D., Grimmond,S.M.,
            Townson,S., Wells,C., Little,M., Cummings,M.C., Hayward,N.K. and
            Kay,G.F.
  TITLE     Mice lacking the vascular endothelial growth factor-B gene (Vegfb)
            have smaller hearts, dysfunctional coronary vasculature, and
            impaired recovery from cardiac ischemia
  JOURNAL   Circ Res 86 (2), E29-E35 (2000)
   PUBMED   10666423
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_006230912.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.3893.1,
                                           SRR22399484.1309898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000001.1  213606838-213607199 c
            363-405             JAXUCZ010000001.1  213606264-213606306 c
            406-602             JAXUCZ010000001.1  213605781-213605977 c
            603-676             JAXUCZ010000001.1  213605515-213605588 c
            677-712             JAXUCZ010000001.1  213605110-213605145 c
            713-847             JAXUCZ010000001.1  213604668-213604802 c
            848-1266            JAXUCZ010000001.1  213601570-213601988 c
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1266
                     /gene="Vegfb"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
     exon            1..362
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..869
                     /gene="Vegfb"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; VRF; VEGF-B; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B isoform 1
                     precursor"
                     /protein_id="NP_001425287.1"
                     /db_xref="GeneID:89811"
                     /db_xref="RGD:619799"
                     /translation="MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYAR
                     ATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQIL
                     MIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDSPRTLCPRCTQRRQRPDPRTCRCR
                     CRRRRFLHCQGRGLELNPDTCRCRKLRR"
     sig_peptide     303..359
                     /gene="Vegfb"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    435..680
                     /gene="Vegfb"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; Region: PDGF; smart00141"
                     /db_xref="CDD:197537"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(435..446,546..548,552..563,606..617)
                     /gene="Vegfb"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(441..443,534..536,546..548,567..569,666..668,
                     672..674)
                     /gene="Vegfb"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     misc_feature    order(516..518,543..545)
                     /gene="Vegfb"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238079"
     exon            363..405
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            406..602
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            603..676
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            677..712
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            713..847
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1266
                     /gene="Vegfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgtccg ccagccccgg ccaggccccc tgccaccccc gccgtccccg ctgcccgccg
       61 tcccggccac caccaccaac acaggccgcc tgcctgtctc gttccttctg ccgccgctga
      121 ggcgctacgt tgcgctgcct gcgcccaggg ctcgggaggg ggccgcggag gagccgcccc
      181 ccgcgcccgg cccggggtcc ccacacccgg gcccgcgcca tgggactctg gctgccgccg
      241 ccccccgcgc cgccgggcta gggcaatgcg gtcgcccccg gcgctcggcc cccgcgggca
      301 ccatgagccc cctgctccgt cgcttgctgc ttgttgcgct gctgcagctg gcctgtaccc
      361 aggcccctgt gtcccagttt gatggcccca gccaccagaa gaaagtggtg tcatggatag
      421 atgtttatgc acgtgccaca tgccagccca gggaggtggt ggtacctctg agcatggaac
      481 tcatgggtaa tgtggtcaaa caactcgtgc ccagctgtgt gactgtgcag cgctgtggtg
      541 gctgctgtcc tgacgatggc ctggagtgtg tgcccattgg gcaacaccaa gtccgaatgc
      601 agatcctcat gatccagtac ccgagcagtc agctggggga gatgtccctg gaagaacaca
      661 gccaatgtga atgcagacca aaaagaaagg agagtgctgt gaagccagac agccccagga
      721 ccctctgccc acgctgcacc cagcgccgtc agcgccctga tccccggacc tgccgttgcc
      781 gctgcagacg ccgccgcttc ctccattgcc aagggcgggg cttagagctc aacccagata
      841 cctgcaggtg ccggaagctg cgaaggtgac aagctgcttt tcggactcca caggcctgtg
      901 tgcctcacag gccttcttca tagggagaag agtggagcat aggagaacca cctcagtctg
      961 ggaggacatt gccccaggac ttggagcttt tagagagctc tcaccatctt ttatctccca
     1021 gagctgcctt ctaacaattg tcaagagaac ctcatgcctc accttagggg ccagggtact
     1081 atctcagtta gccactctgg tcaagtgaac atcttgctgg ctgtctcccc tcactatgaa
     1141 gaccccaaac ttctaccaat actaggactt gggttgttat gataactgtg acacacacac
     1201 acacacacac acacacacac acacacacac acacacacac tctgataaaa gaaatggaag
     1261 acacta
//
LOCUS       NM_001438538            3337 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus sterile alpha motif domain containing 12
            (Samd12), transcript variant 2, mRNA.
ACCESSION   NM_001438538
VERSION     NM_001438538.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840130,
                              SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000007.1  87161406-87161459   c
            55-233              JAXUCZ010000007.1  87105242-87105420   c
            234-363             JAXUCZ010000007.1  86947062-86947191   c
            364-504             JAXUCZ010000007.1  86856724-86856864   c
            505-3337            JAXUCZ010000007.1  86656303-86659135   c
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..3337
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="sterile alpha motif domain containing 12"
                     /db_xref="GeneID:362910"
                     /db_xref="RGD:1561402"
     misc_feature    24..26
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="upstream in-frame stop codon"
     CDS             42..527
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sterile alpha motif domain-containing protein 12"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 12
                     isoform 2"
                     /protein_id="NP_001425467.1"
                     /db_xref="GeneID:362910"
                     /db_xref="RGD:1561402"
                     /translation="MAVEALHCGLNPQSIDHPAHADGIKLQIEGEGVESQSIKNRNFQ
                     KVSDQKGTPKRLQGEAETAKSATVKLSKPVALWTQQDVCKWLKKHCPNQYHIYSESFK
                     QHDITGRALLRLTDKKLERMGVAQENQRQHILQQVLQLKVREEVRNLQLLTQASTDCS
                     P"
     misc_feature    255..479
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="SAM domain of aveugle-like subfamily; Region:
                     SAM_aveugle-like; cd09510"
                     /db_xref="CDD:188909"
     misc_feature    255..479
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="SAM domain of aveugle-like subfamily; Region:
                     SAM_aveugle-like; cd09510"
                     /db_xref="CDD:188909"
     misc_feature    order(345..359,366..371,378..380,393..395,402..407)
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="heterodimer interface ML [polypeptide binding];
                     other site"
                     /db_xref="CDD:188909"
     misc_feature    order(345..359,366..371,378..380,393..395,402..407)
                     /gene="Samd12"
                     /gene_synonym="RGD1561402"
                     /note="heterodimer interface ML [polypeptide binding];
                     other site"
                     /db_xref="CDD:188909"
ORIGIN      
        1 ggccaagaaa attatgcatg cgttaggcaa gctctgagag aatggctgtg gaagctctcc
       61 actgtggttt gaatccacag agtattgatc accctgccca tgctgacgga attaaactgc
      121 aaattgaagg tgaaggtgta gaatctcaat ccattaagaa cagaaatttc cagaaggtat
      181 ctgaccaaaa aggaaccccc aagagacttc agggagaagc tgagacagca aagtcagcta
      241 cagtgaagct gtcaaaaccg gtggccctgt ggacccagca ggatgtgtgc aagtggctga
      301 agaaacactg tccaaatcag tatcacatct acagtgagtc attcaagcaa catgacataa
      361 ctgggcgagc cctgctgaga ctcacagaca agaagctgga gcgcatgggg gtcgcccagg
      421 agaaccagcg acagcacatc ctgcagcagg tgctccaact gaaggttcgg gaagaagtca
      481 gaaacctgca gttactcaca caagcctcga cggattgttc tccataacca tgttagccca
      541 gcaagccgct gtcctgccag tggataagag tgtgacctgt tccccagaga aatactgact
      601 catggccctg ccagaagaga tccttggagc actgacagat taaccagact gactgagaaa
      661 acgcctattc agtcaagatt atggactttg cgagcagaaa aaaaaaaacc ttagtttgct
      721 gtggattttc aaatgaggtg cataacatac agtgccaact cattccaagt ggtcattggc
      781 agaccattag ccagaaattg gcttctggtt ttcatcactg tgcataactc aagttcccct
      841 tgggctccat ctgtgcccct cactacaagt tctgttttag catggcaacc actggattat
      901 tttcattaag tgtgcagatg gcatgatgtt ctagaaaaac aaatacaaga gttctgcaat
      961 ctcagtggaa gggttcgaaa tagtgtgccc tggtaggaat gtaaacatgt ctagattatg
     1021 ttagtggcaa tgtccaaagg tgtcctgtcc aacactgaag cactttatat aagaacacta
     1081 cactgaggta aaatagcaca tttgatacat gtaagaaaac aagtgtttcc tcttttcttt
     1141 ataaatcttg tcttatttct ggctcagact gtccaaaacc aactctcctc ctagtatact
     1201 cacagttgtt tgtggtagat cagtgtaaat atggccacaa tactgttaca cttcacctgg
     1261 tgacacttaa ctagatacct ggattcctta gagcacaaaa ggaagtagac tcaagcatgg
     1321 tgactcttgg ttctttatac caggcacaac ttaacatatg acataaggac agtcttccag
     1381 gatgcttctc tttggctgat gtatgcatag ccttgtccca taaaggagat cttccaagta
     1441 aaaaagaaga tgaccctctt tacatcaaag accattgtgg atggctgcca agggcagcag
     1501 aatgcaatct tccttagtgg ttccacctac acacttagga aatcttccca aggtcacatt
     1561 taagtcacag ttctggagag aagccgcaaa tgacctccac tgtgtgccta gagaagtaac
     1621 acatttagcc cacacaaggt ttcttcctcg gcatagaaat tattcttcct tttaatacct
     1681 cctggaatgt ctatgtaact ttttttgatt ctgaaaacaa agaacagtcc tgggaaacct
     1741 gtctgtttga tgatggctta cctgaacact agggaagtgt tctttcctat ggattgcccc
     1801 cttgtgatac attaacattt tcccctggaa atagaaactt ggctgaatca aaaactcagc
     1861 aaagtatatt atgagcactt attatgaacc taacccatga ccaacaggaa tagatgtaac
     1921 aatccggaac cttcccataa gcaaccaaga catgtcatgt tgtcttcaag cattcattgt
     1981 ttgtccccac ttgtggtctc aagaagtaga aagagctgag tggtgatgta cacagggtat
     2041 ctctctacag catggctcct gtcagaatgt gggctagaga aggggttcct aatagggatg
     2101 tcagagaaat gattgttccc atgagatctg gactttttac caacagatca ccaccagaac
     2161 catctaagcc accaccggcc ataattttct gagaagctgg aactgatcat ccaaacccag
     2221 gctgctgaca ttccatccct atgacccatc cattcacctt agttcccacc gtagggctta
     2281 tgtgcccccc tttccttctt ttcattcagc aggcatctgt tgagggacaa caccatgtgc
     2341 caagaactat actggctcta ctgtagtata taaagcacat tcttcctgct tctattaaat
     2401 cactttcttt ttctcaagca gtcccctttt ttcccacagt gtaaactgaa ttgagacacc
     2461 cacactcatc cccttcccct tgccacagaa acttaggaaa atgttcatgg cagacagcag
     2521 gtagagctct tgcctgaatg agtgggcagc taaatggcac atatggaatc ttgctaagtg
     2581 gccagctaag tcgatcagag cttctctcag aagctcttcg ttgttttcct tgatgcccac
     2641 ccccgtctct atacttccaa tccttctata gacactactg tttatcacta tgctggattc
     2701 tctgaaatgc caattccata actactccta aagacccgga attggttcta atgaatcctg
     2761 taaaccctgc tgggtgctga gatactgtac atgggaatta actggtatag tcagtgatat
     2821 tctgagactc ctgctagcac ccttggaaaa ctggatgcac attatagtgc agatgtccac
     2881 taaatgatca cgggctattg ctattttggc ttttgcaaaa ataatctgaa caattaaaaa
     2941 gagttgcctc cttttttttc taagtcagag gagtactgta ataccattga aagataatgg
     3001 gtaaagatga aaatgggaaa aggcaaaatg aaggtcctta aagagcccag tcgacaatgg
     3061 tgtctctaaa tatgccttaa tgcttggcac aacctacata tttgaatatt aggtcatact
     3121 gctttccaaa ctgtcaacct ctgtttgaaa ttattatagg ttagaaagca cggtggtaca
     3181 aaacctttgc aagcactagc aaaaccagga aaatggagaa gttcttttat tcacagcctt
     3241 cggcttcctt gtatggagat gctttgtgaa attaccccgt cattccttct tgctgtgctg
     3301 tgtatgttgg gatggggatt gaaattttat cttccag
//
LOCUS       NM_001107092            2844 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 9, mRNA.
ACCESSION   NM_001107092 XM_001062923 XM_221420
VERSION     NM_001107092.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2844)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473967.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221420.4, XM_001062923.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2844
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..33
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            34..103
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    74..76
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     exon            104..215
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1789
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 3 is encoded by transcript variant 9; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 3"
                     /protein_id="NP_001100562.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMSMLYICLCFINGITHARDVASKIFRSATNSLYSSP"
     misc_feature    983..>1063
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    983..>1063
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    <992..>1339
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <992..>1339
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="Myosin heavy chain [General function prediction
                     only]; Region: COG5022"
                     /db_xref="CDD:227355"
     misc_feature    <1268..>1405
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    <1268..>1405
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    1289..1345
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1289..1345
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            216..378
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            379..508
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..602
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            603..702
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            703..881
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            882..991
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1101
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1244
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1393
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1525
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..2844
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacacagc tcggcgaagg ccgccacgct gagtgattcc tggaagcagt gaagggcacg
       61 gccttgggat tcttgattcc tcaaaggtca gcctagcaac agggtggtag aaaaaatgaa
      121 gccagcgggt acagacccaa ggatcttgtc tttagctgct gaagtagcga aaagtcctga
      181 acaaaatgtc cctgttatat tattgaagtt aaaagaaata ataaacaaca cccctttggg
      241 aagctcagag ttaaagaaag tcaagcaaga tatatattgt tatgacctca ttcaatactg
      301 tctattggtc ctcagtcaag attcttctcg aatccagggt ggttggtcta caatttccca
      361 gctgacacag atactaagcc attgctgtgt gggattagag ccaggagaag atggagaaga
      421 attttacaag gaattacttc catcagctgc cgaaaatttt cttgtcctgg gaagacgatt
      481 gcaaacatgt tttatcaatg caactaaggg tgaagagcaa gataaattac tacatttttt
      541 ccaaattgtg actgattctc tcttctggct attgggaggt catattcaac tcatacagaa
      601 tgtactgcag agtgatcatt tcttgcacct actgcaaact gacaatgttc aaataggagc
      661 tacagtcatg actctgcttc agaatatact acagatcaac agtggtaatt tactcaaaat
      721 agaaggaaaa gccctgcatt ctattttaga tgaaattctt ttcaagcttt tgtcaactcc
      781 tagtccagtc ataagaagta ctgctacaaa gctcctactg gtattggctg aatcccatca
      841 ggaaattttg attttactga gactaagtgc ctgctataaa ggacttagaa gtctgctaaa
      901 taaacaggaa actcttacag aatttagtcg agaacttaga cagctcgttg atcttttaac
      961 ccctaagatc caacaggaag tagaagaaca gaaactacat aaagcagctt gcttgattca
     1021 agcctattgg aaaggtttcc agaccagaaa aagattaaag aagcttccgt ctgctgtgat
     1081 tgccttgcag aggagtttca gagctaaacg aacaaagatg ttgttggagc taaataggca
     1141 gaaggaagaa gaagacctca gattaagatt gcaacttcaa aaacagagag ccatgaggct
     1201 ttcccgagag tcacgcttga gtatgcttga aataattcat ccaggtcaag tggagaaata
     1261 caatagggaa atagaagaga aatctgcatt gactatccag aaacattgga gagggtacag
     1321 ggaaaggaag aattttcgcc aacagaggcc atctctcaca gagtataaag cagctgtcac
     1381 acttcagaga gcagttctta aattcctagc aaagtgccgt aagaaaaaga aactctttgc
     1441 ctcttggcat ggactccaag aactcactga tgcacgccga gttgaactga agcaacaagt
     1501 ggatgactat gtcaaaagac atccgggctc tcagatgtca gatgtggcca gcagagagct
     1561 ccacgcacaa gcacaagaac gacttcaaca ctattttatg ggaagagcca tagaagagcg
     1621 agcccagcaa cacagggaag cattgatggc tcagatcagc accaatattg agcagttgat
     1681 gagtatgctc tacatctgtc tttgtttcat aaatggaata acccatgcaa gagacgtggc
     1741 atccaaaatc tttagaagtg ccacaaatag tctttattcc agtccttagg aaatcttaca
     1801 tcatcccagt tttcaactgt atacattcca tttgttataa attcaaatat ttcaactcca
     1861 tccaaattac taattttaaa gatgctgtgc tcttctacac acattctgcc taaacttttt
     1921 aaattttttt ttgtatttta gaattagata atgacagcag ttacagtaca gtgacctttt
     1981 caaaaataac atttaatgat tttttactga agttttgctc tctttaagct atctaacaca
     2041 acttactgtt tttctcttct aaaagactta aaaagactgg aagttgccag ggattggggt
     2101 tgttgctgtc acccacatct gtaacttttt actagacacc taccttcata gttagcagtg
     2161 acagcatagt cagagttaga gcccatcctg tcctgtcctg tcctaactgt agctaggctc
     2221 cagctctgct ggttccaagt ctgcttgcct ggcgtccttc cactgaccca tttactttct
     2281 gtttgctgca gaggcaccaa gtctgaagga ggcggaagga aaggagcctg agcagttcct
     2341 gagtagatct aggcctgtgg cagccaaagc caagcaggcc caccttacca ccctgaagca
     2401 catacaggcc ccctggtgga agaagctcgg agaggaacca ggggatgaga tggatgttcc
     2461 aaaggacgag cttagtatag atttagggac tttatttatt ggtggaacca agcctcccta
     2521 gagagttact gggaaagccg gcattcttac cttttaagag attgttggtt ttgcctctgg
     2581 catgcaggaa gactaggtct atgccagtgg ctttccagag catcttcttc atgaacactt
     2641 ggaagcaaag agcagagcat tgcctacctc actctcagtt ctttccccat ctctacaccc
     2701 tgtctgtagt cacaaacaga tttgtgggct tttaattgtg ggacagaact caatgtgaaa
     2761 ttttattgtt aatttgaaat ttctttcatt ctgttttctg actaaaagtt gttttgtttt
     2821 tgtttttaaa taaatattgt ttct
//
LOCUS       NM_001437764            2248 bp    mRNA    linear   ROD 21-APR-2025
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), transcript
            variant 3, mRNA.
ACCESSION   NM_001437764 XM_006248397
VERSION     NM_001437764.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 9, 2025 this sequence version replaced XM_006248397.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.476807.1,
                                           SRR26360186.1336005.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000011.1  77465446-77465485   c
            41-110              JAXUCZ010000011.1  77464858-77464927   c
            111-222             JAXUCZ010000011.1  77462369-77462480   c
            223-385             JAXUCZ010000011.1  77461993-77462155   c
            386-515             JAXUCZ010000011.1  77456828-77456957   c
            516-609             JAXUCZ010000011.1  77452674-77452767   c
            610-709             JAXUCZ010000011.1  77449073-77449172   c
            710-888             JAXUCZ010000011.1  77444544-77444722   c
            889-998             JAXUCZ010000011.1  77442290-77442399   c
            999-1108            JAXUCZ010000011.1  77440692-77440801   c
            1109-1251           JAXUCZ010000011.1  77435682-77435824   c
            1252-1400           JAXUCZ010000011.1  77433449-77433597   c
            1401-1532           JAXUCZ010000011.1  77424393-77424524   c
            1533-1689           JAXUCZ010000011.1  77412154-77412310   c
            1690-2248           JAXUCZ010000011.1  77410986-77411544   c
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2248
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..40
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            41..110
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    81..83
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="upstream in-frame stop codon"
     exon            111..222
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1919
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="isoform 1 is encoded by transcript variant 3; IQ
                     calmodulin-binding motif-containing protein 1; IQ
                     calmodulin-binding motif containing 1; nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein 1
                     isoform 1"
                     /protein_id="NP_001424693.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWK
                     KLGEEPGDEMDVPKDELSIDLGTLFIGGTKPP"
     misc_feature    837..>1412
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    837..>1412
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="C-terminal middle region of Androglobins (Adgbs)
                     and related proteins; including permuted globin domain and
                     IQ motif; Region: Adgb_C_mid-like; cd22307"
                     /db_xref="CDD:412094"
     misc_feature    837..896
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    837..896
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix E [structural motif]; Region: globin
                     helix E"
                     /db_xref="CDD:412094"
     misc_feature    939..968
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    939..968
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix F [structural motif]; Region: globin
                     helix F"
                     /db_xref="CDD:412094"
     misc_feature    990..>1070
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    990..>1070
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); Region: IQCD; cd23767"
                     /db_xref="CDD:467745"
     misc_feature    1002..1064
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1002..1064
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix G [structural motif]; Region: globin
                     helix G"
                     /db_xref="CDD:412094"
     misc_feature    1089..1229
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1089..1229
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="globin helix H [structural motif]; Region: globin
                     helix H"
                     /db_xref="CDD:412094"
     misc_feature    1296..1352
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     misc_feature    1296..1352
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif [structural motif]; Region: IQ motif"
                     /db_xref="CDD:412094"
     exon            223..385
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            386..515
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..609
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            610..709
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            710..888
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            889..998
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1108
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1251
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1400
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1532
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1689
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2248
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgacgc acacagctcg gcgaaggccg ccacgctgag tgattcctgg aagcagtgaa
       61 gggcacggcc ttgggattct tgattcctca aaggtcagcc tagcaacagg gtggtagaaa
      121 aaatgaagcc agcgggtaca gacccaagga tcttgtcttt agctgctgaa gtagcgaaaa
      181 gtcctgaaca aaatgtccct gttatattat tgaagttaaa agaaataata aacaacaccc
      241 ctttgggaag ctcagagtta aagaaagtca agcaagatat atattgttat gacctcattc
      301 aatactgtct attggtcctc agtcaagatt cttctcgaat ccagggtggt tggtctacaa
      361 tttcccagct gacacagata ctaagccatt gctgtgtggg attagagcca ggagaagatg
      421 gagaagaatt ttacaaggaa ttacttccat cagctgccga aaattttctt gtcctgggaa
      481 gacgattgca aacatgtttt atcaatgcaa ctaagggtga agagcaagat aaattactac
      541 attttttcca aattgtgact gattctctct tctggctatt gggaggtcat attcaactca
      601 tacagaatgt actgcagagt gatcatttct tgcacctact gcaaactgac aatgttcaaa
      661 taggagctac agtcatgact ctgcttcaga atatactaca gatcaacagt ggtaatttac
      721 tcaaaataga aggaaaagcc ctgcattcta ttttagatga aattcttttc aagcttttgt
      781 caactcctag tccagtcata agaagtactg ctacaaagct cctactggta ttggctgaat
      841 cccatcagga aattttgatt ttactgagac taagtgcctg ctataaagga cttagaagtc
      901 tgctaaataa acaggaaact cttacagaat ttagtcgaga acttagacag ctcgttgatc
      961 ttttaacccc taagatccaa caggaagtag aagaacagaa actacataaa gcagcttgct
     1021 tgattcaagc ctattggaaa ggtttccaga ccagaaaaag attaaagaag cttccgtctg
     1081 ctgtgattgc cttgcagagg agtttcagag ctaaacgaac aaagatgttg ttggagctaa
     1141 ataggcagaa ggaagaagaa gacctcagat taagattgca acttcaaaaa cagagagcca
     1201 tgaggctttc ccgagagtca cgcttgagta tgcttgaaat aattcatcca ggtcaagtgg
     1261 agaaatacaa tagggaaata gaagagaaat ctgcattgac tatccagaaa cattggagag
     1321 ggtacaggga aaggaagaat tttcgccaac agaggccatc tctcacagag tataaagcag
     1381 ctgtcacact tcagagagca gttcttaaat tcctagcaaa gtgccgtaag aaaaagaaac
     1441 tctttgcctc ttggcatgga ctccaagaac tcactgatgc acgccgagtt gaactgaagc
     1501 aacaagtgga tgactatgtc aaaagacatc cgggctctca gatgtcagat gtggccagca
     1561 gagagctcca cgcacaagca caagaacgac ttcaacacta ttttatggga agagccatag
     1621 aagagcgagc ccagcaacac agggaagcat tgatggctca gatcagcacc aatattgagc
     1681 agttgatgaa ggcaccaagt ctgaaggagg cggaaggaaa ggagcctgag cagttcctga
     1741 gtagatctag gcctgtggca gccaaagcca agcaggccca ccttaccacc ctgaagcaca
     1801 tacaggcccc ctggtggaag aagctcggag aggaaccagg ggatgagatg gatgttccaa
     1861 aggacgagct tagtatagat ttagggactt tatttattgg tggaaccaag cctccctaga
     1921 gagttactgg gaaagccggc attcttacct tttaagagat tgttggtttt gcctctggca
     1981 tgcaggaaga ctaggtctat gccagtggct ttccagagca tcttcttcat gaacacttgg
     2041 aagcaaagag cagagcattg cctacctcac tctcagttct ttccccatct ctacaccctg
     2101 tctgtagtca caaacagatt tgtgggcttt taattgtggg acagaactca atgtgaaatt
     2161 ttattgttaa tttgaaattt ctttcattct gttttctgac taaaagttgt tttgtttttg
     2221 tttttaaata aatattgttt ctgaaaaa
//
LOCUS       NM_001438189            4530 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus zinc finger with KRAB and SCAN domains 4
            (Zkscan4), mRNA.
ACCESSION   NM_001438189 XM_063276949
VERSION     NM_001438189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4530)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 16, 2025 this sequence version replaced XM_063276949.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2060846.1,
                                           SRR26360186.2096928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-664               JAXUCZ010000017.1  47808198-47808861   c
            665-821             JAXUCZ010000017.1  47806284-47806440   c
            822-4530            JAXUCZ010000017.1  47800040-47803748   c
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..4530
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="zinc finger with KRAB and SCAN domains 4"
                     /db_xref="GeneID:291164"
                     /db_xref="RGD:1309004"
     exon            1..664
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    242..244
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="upstream in-frame stop codon"
     CDS             248..1690
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="zinc finger protein 307; zinc finger protein with
                     KRAB and SCAN domains 4-like"
                     /codon_start=1
                     /product="zinc finger protein with KRAB and SCAN domains
                     4"
                     /protein_id="NP_001425118.1"
                     /db_xref="GeneID:291164"
                     /db_xref="RGD:1309004"
                     /translation="MAREPGACAALNAPSAEEGTGFLVVKVEPEEASQLAEEPSWLGS
                     PGPDRSRQRFRAFRYPDAAGPRQALSRLRELCRQWLRPDMHSKEQILELLVLEQFLTI
                     LPGELQAWVREQHPDSGEEVVALLEYLDRQLDETPPQVPTGEWSRELLCCKVALVTSS
                     QDSQSSHSQAMKSLFKHESQESLECSPLQARGLEMKPETRGLPLAEEYKEQKPEQTVW
                     FLGEDTVQISTSTEASEQEGKLQTTQKNATGNRRFYCHECGKSFAQSSGLTKHKRIHT
                     GEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGE
                     KPYECDDCGKTFTQSCSLLEHHKIHTGEKPFQCNLCGKAFRRSSHLLRHQRIHGDKAA
                     PKLLHGETWEGQSRVASLGDIVEAPETYQCNECERSFTRSRSLIEHKKIHTGEKPYQC
                     DACGKGFTRTSYLVQHRRSHVGKKLSHSDL"
     misc_feature    386..715
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    386..715
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="leucine rich region; Region: SCAN; smart00431"
                     /db_xref="CDD:128708"
     misc_feature    1004..1072
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1004..1072
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1010..1072
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1010..1072
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1010..1012,1019..1021,1058..1060,1070..1072)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1010..1012,1019..1021,1058..1060,1070..1072)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1049..1117
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1049..1117
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1088..1156
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1088..1156
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; pfam00096"
                     /db_xref="CDD:395048"
     misc_feature    1094..1156
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1094..1156
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    <1166..1660
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    <1166..1660
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1178..1240
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1178..1240
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1178..1180,1187..1189,1226..1228,1238..1240)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1178..1180,1187..1189,1226..1228,1238..1240)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1193..1195,1199..1201,1205..1207,1211..1216,
                     1223..1228,1235..1237,1277..1279,1283..1285,1295..1300,
                     1307..1312,1319..1321,1361..1363,1367..1369,1373..1375,
                     1379..1384,1391..1396,1403..1405)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1193..1195,1199..1201,1205..1207,1211..1216,
                     1223..1228,1235..1237,1277..1279,1283..1285,1295..1300,
                     1307..1312,1319..1321,1361..1363,1367..1369,1373..1375,
                     1379..1384,1391..1396,1403..1405)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1262..1324
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1262..1324
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1346..1408
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1346..1408
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1511..1573
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1511..1573
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1511..1513,1520..1522,1559..1561,1571..1573)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1511..1513,1520..1522,1559..1561,1571..1573)
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1595..1657
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1595..1657
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            665..821
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /inference="alignment:Splign:2.1.0"
     exon            822..4530
                     /gene="Zkscan4"
                     /gene_synonym="Zfp307; Znf307"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggttccca cagtgcttcc cgtgctccac cagcgtctga atgtagttta tttgccttgg
       61 aacatccctt gagaatatgt tttgtgagtt tagggtggag tgcagaagta taggtgacac
      121 ctctgaagct ttgcttttgg gtgtcccgga gcacgagggg agggaggaag cagatctgaa
      181 ttcccatctt gcgagaatct tctgcagatc cagcttgcag ctagcgtgag cctccagttg
      241 gtagagaatg gctagagaac ccggagcgtg cgcagcccta aacgctccat ctgcagaaga
      301 ggggactggg tttctagtgg tgaaagtgga accggaagag gcctcccagt tggcagagga
      361 gcccagttgg ctgggcagtc ctgggcctga ccgctcccgc cagcgcttcc gtgctttccg
      421 ctacccagac gcagcagggc cccggcaggc gctgagccgg ctccgcgagc tatgcagaca
      481 gtggctgcgg ccagacatgc acagcaagga gcagatcctg gagctgctgg tgctggagca
      541 gttcctgacc atcctgccag gggagctgca ggcctgggtg cgcgagcagc accccgacag
      601 cggagaggag gtggtggcac tgctggagta cttggacagg cagctggatg agacccctcc
      661 acaggtccca actggggaat ggagtcgaga acttctctgc tgcaaggtgg cattggtgac
      721 atcatcccag gattcacaaa gtagtcactc ccaggcaatg aagtctctct tcaagcatga
      781 atctcaggaa tctttggagt gttcaccctt acaagccaga ggtctggaaa tgaagcctga
      841 gaccaggggc ttgcctctag ctgaggaata caaggaacaa aagcctgagc agacagtgtg
      901 gttcctgggt gaagacactg tccagatttc tacaagtaca gaagccagtg agcaggaagg
      961 caagttacag acaacacaga agaatgccac gggaaacagg cggttctact gccatgaatg
     1021 tgggaagagc tttgctcaga gttcaggcct gaccaaacac aagagaatcc acactggaga
     1081 gaaaccctat gaatgtgaag actgtgggaa gacctttatt gggagctctg ctcttgtcat
     1141 tcatcagaga gttcacactg gtgagaagcc atatgagtgt gaagaatgtg gcaaagtctt
     1201 cagtcacagc tcaaacctca tcaagcacca gagaacccac actggagaaa agccttatga
     1261 gtgtgatgac tgtgggaaaa ccttcactca gagctgtagc ctcctggaac accataaaat
     1321 tcacactggt gagaagccat tccaatgcaa cttgtgtggc aaagccttta ggcgtagctc
     1381 ccatctcctg agacatcaac ggatccatgg tgataaagct gctccgaagc ttcttcatgg
     1441 agagacctgg gaaggtcaga gtagggtggc aagcctgggg gatattgttg aagctcctga
     1501 gacttatcag tgcaatgagt gtgagagaag tttcactcgg agtagaagtc ttattgaaca
     1561 taaaaaaatt cacactggtg agaaacccta ccagtgtgat gcatgtggga aaggctttac
     1621 ccgaacttca taccttgttc aacatcgaag aagccatgtg ggaaaaaagt tgtctcacag
     1681 tgacctgtag cacacctgcc agacttggtg agcacttgcc agtgagatga agacacctgg
     1741 aacccttact aactgcagaa gagagggtgt tgccaataca cactgtcctg tgttagacat
     1801 tatggtctgg ctgaggtaga ttatttcttc tgtttaaaaa gtaactggaa taagacttac
     1861 taataggagg atgtggcggt gttctctgga tgagataatg ctgaagtgtt cccactcttt
     1921 ggatttacaa ggacttccag aacaactgtc gcccttggcc ggcgtatttt tctcctgagt
     1981 ggatggttcc agattttgga gtgtaccttc tttactattt ggttgtcagc ttgaattttt
     2041 catgtttaat cagattcttg aggccttggc tcctctattg tgccttgtgt agaggtgcta
     2101 gtaaacattt actacaagaa ctgatgaatg tccatcaaaa ctggaaatca gggtctagat
     2161 ttctgaagaa gttctgactt gtagtgtttg tgtttgcatc taactggcaa agatactaga
     2221 gtctgagtca gccctacagt tttcatacta agtacagaat gttacagagt ttgagtagga
     2281 gattctgtat atctttatga ggatagagag tgtagtaaga atgcctcagg caacttctga
     2341 agatgtaggg aaacatccac acccagaaaa gctccattac agcatactta gttttttttt
     2401 tttttttttt tttacttttt actgtgaacg ttttcagtta ggtaaataaa aagcaacctt
     2461 attttcatgg gacaaaatct tatagttagg atttttattg ctttgaaaaa cactatggca
     2521 aaaagcaacc tggggtgggt gggtgtttat ttaaacttac aacttattta ttacacgcat
     2581 cactgaggga agcctgggca ggagcacaac ctacggagag caggaacctg gaggcaaaac
     2641 tgaagcagag gttatggagg agtgctgctt atgggcttgc tccctaaggg ctggctcctg
     2701 atgtctgaat caacctgctt tattatagat ctcaggacct ctagccttgg gggtgatacc
     2761 acccacagtg atttgggtct tcccacatca gtcatcaatc aaaaaaaaaa aatggcccat
     2821 aggcttccct gcaggccagt ctggtggtgg cattttataa gttgaggttc cctcttccca
     2881 aatgactctg ttttgtgttg agttgacaga aaactagcca gtacaacaaa tgatacagat
     2941 tatgtcaatt ctataatgct caaagtactg ttagttactt ttctaagggc tgtgactaca
     3001 aacgcaagaa aaagcaactt aaggagggaa tcggttatct gggttcatga tttgagatga
     3061 tacattatgg tggtcttgag gaaggagtgt ttgggagagg tgaaagaaac tactcatagt
     3121 caattgggga gggggtataa gctgacagct ttgtgttctg ctagagatgg ctctccagac
     3181 agctctgtag ttagctcttg gctctgtagt ctgatcaaga cgtcttcctg ttagagacag
     3241 ctctctcgtg ctagaaaaaa atattcttgg atttttccaa ccaaaatcag aaaagctact
     3301 agaaaaaaaa tttggggggt tttctgacca aaatcagaaa tcctgttaaa ataattctta
     3361 aagagctgag ttctctttct aagcagtttt ctctggtagc tctctcttgc agaccaaagc
     3421 ccaatcttat ttacatatca attcagtcat ttactccaag atcccttttg tttatcccca
     3481 tgaataagca ttttatacct tagctacttg attcttaaaa aaggacagca agtaaatttt
     3541 gttttttaaa acacagcaaa tgaattcaaa gatctgtcta cttttgtaag cacagacgat
     3601 aaggatccag ctctgagatc accattttca cctctcctgg acctgaattc tctgtcccag
     3661 gataaccttg aacttgggaa tctgcctgcc tttataagca caaacaataa acttagctag
     3721 gtaggatctt gctctgccat caccactctc caaatctctt tatctccttc cttaatatct
     3781 ttctaacaag ctggtttaca gtgaagctgg tatgtgaagc ccctcatata atttatattg
     3841 catccgtata ttttgcatag ttgagaaatt atttattttt gaactcttgt tttcagagtt
     3901 ctttttcaca accttaacaa ctatcctgaa ggttatagtg tttaccattt ttgccaagga
     3961 cccagacata cctttgcctc ctggagtcat gctgtctctg gttaccaagt agtcattaac
     4021 cttggcagag atgacattcc ccaataacct tggcaggaag aatatttcct gaaggaggaa
     4081 cataaagtta atgtatatat tatacaaaca atcctcatgc ccagtgagag actagatatt
     4141 ttgggttaag actccatctt agagaacatg acctaaggtt gaactcaagt taactaacag
     4201 gcagatacct agtaccagtt tccaggttat tcccccaaca aatctgcacc tcggttacaa
     4261 acctgcccct gaagcttcat ttcctaacaa ccagcaatca ggaggaaagc agaagttaga
     4321 ttaatgattt ggctccaagt tccagccaat tatgttaaag gccataaatg acccccaccc
     4381 ccgaaatctg atgtgtacca gtctagaaac ccccttgttt ctataaatgc ttgcctgaaa
     4441 ttaagcttag gtctgcctct cccattctcc tgcatcagag atgacagtgt agtccaaact
     4501 caagcttgta ataaagagac ctgaatgcaa
//
LOCUS       NM_001191620            4323 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus zinc finger protein 418 (Zfp418), transcript
            variant 1, mRNA.
ACCESSION   NM_001191620 XM_218208
VERSION     NM_001191620.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4323)
  AUTHORS   Singh,S.R., Meyer-Jens,M., Alizoti,E., Bacon,W.C., Davis,G.,
            Osinska,H., Gulick,J., Reischmann-Dusener,S., Orthey,E.,
            McLendon,P.M., Molkentin,J.D., Schlossarek,S., Robbins,J. and
            Carrier,L.
  TITLE     A high-throughput screening identifies ZNF418 as a novel regulator
            of the ubiquitin-proteasome system and autophagy-lysosomal pathway
  JOURNAL   Autophagy 17 (10), 3124-3139 (2021)
   PUBMED   33249983
REFERENCE   2  (bases 1 to 4323)
  AUTHORS   Pan,L., Sheng,M., Huang,Z., Zhu,Z., Xu,C., Teng,L., He,L., Gu,C.,
            Yi,C. and Li,J.
  TITLE     Zinc-finger protein 418 overexpression protects against cardiac
            hypertrophy and fibrosis
  JOURNAL   PLoS One 12 (10), e0186635 (2017)
   PUBMED   29065170
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 17, 2025 this sequence version replaced NM_001191620.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.1218.1,
                                           SRR26360172.2032105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000001.1  75614540-75614743
            205-243             JAXUCZ010000001.1  75615306-75615344
            244-370             JAXUCZ010000001.1  75617889-75618015
            371-4323            JAXUCZ010000001.1  75623415-75627367
FEATURES             Location/Qualifiers
     source          1..4323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..4323
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="zinc finger protein 418"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
     exon            1..204
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    55..57
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream in-frame stop codon"
     misc_feature    109..111
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MKAKKTVGSSGSCVRAPALSTEP"
     CDS             178..2160
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 418 isoform 1"
                     /protein_id="NP_001178549.1"
                     /db_xref="GeneID:292548"
                     /db_xref="RGD:1311663"
                     /translation="MAAVKHLAQIPRCTETGMICTQGCVTIEDVTVYFSQEEWKLLDE
                     AQRLLYLDVMLENFTLISSLVYRYEAEAEEKTCAQSLSQTEAPQVRTPKQGQLRQKPH
                     PSDICITVLKDILHLNDLPGQKPYLTEVCTKPQDHKHHRAKNWLKRDVDSLVKSCIFH
                     VAGNPFICSKIGEKFPAIWNLLQPKDIPNGEKQNKIKRGKAFHRDKNNSESDEYKKSS
                     SPQHRLHEYPGVCSAKGGFESNSCEQDLNKYSPAPFRMDQTENRPYECHVCGKWFGQK
                     ATLRIHQRRHTGEKPYKCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSS
                     LLRHQRTHTGEWPYECSDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLT
                     VHQRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYECGECGLCFRQRATLMKH
                     QRTHTSERPYECRECGKFFKQYFYLIEHRRIHTTTEFYECEQCGKSYTQKATLIRHQR
                     VHTGESPYKCEECGKAFEYKSRLKRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIH
                     TKAKPYHCDQCGKCFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHTG
                     ERPYECDQCGKSFSQVSTLTRHQLLHTGEKPYKCSK"
     misc_feature    247..369
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    247..369
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="KRAB box; Region: KRAB; pfam01352"
                     /db_xref="CDD:460171"
     misc_feature    973..1035
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    973..1035
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(988..990,994..996,1000..1002,1006..1011,1018..1023,
                     1030..1032,1072..1074,1078..1080,1090..1095,1102..1107,
                     1114..1116,1156..1158,1162..1164,1168..1170,1174..1179,
                     1186..1191,1198..1200)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(988..990,994..996,1000..1002,1006..1011,1018..1023,
                     1030..1032,1072..1074,1078..1080,1090..1095,1102..1107,
                     1114..1116,1156..1158,1162..1164,1168..1170,1174..1179,
                     1186..1191,1198..1200)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1045..2118
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1045..2118
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    1057..1119
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1057..1119
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1141..1203
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1141..1203
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1225..1287
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1225..1287
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1309..1371
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1309..1371
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1324..1326,1330..1332,1336..1338,1342..1347,
                     1354..1359,1366..1368,1408..1410,1414..1416,1426..1431,
                     1438..1443,1450..1452,1492..1494,1498..1500,1504..1506,
                     1510..1515,1522..1527,1534..1536)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1324..1326,1330..1332,1336..1338,1342..1347,
                     1354..1359,1366..1368,1408..1410,1414..1416,1426..1431,
                     1438..1443,1450..1452,1492..1494,1498..1500,1504..1506,
                     1510..1515,1522..1527,1534..1536)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1393..1455
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1393..1455
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1477..1539
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1477..1539
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1561..1623
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1561..1623
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1645..1707
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1645..1707
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1729..1791
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1729..1791
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1813..1875
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1813..1875
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1897..1959
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1897..1959
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    order(1912..1914,1918..1920,1924..1926,1930..1935,
                     1942..1947,1954..1956,1996..1998,2002..2004,2014..2019,
                     2026..2031,2038..2040,2080..2082,2086..2088,2092..2094,
                     2098..2103,2110..2115,2122..2124)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    order(1912..1914,1918..1920,1924..1926,1930..1935,
                     1942..1947,1954..1956,1996..1998,2002..2004,2014..2019,
                     2026..2031,2038..2040,2080..2082,2086..2088,2092..2094,
                     2098..2103,2110..2115,2122..2124)
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1981..2043
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1981..2043
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2065..2127
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    2065..2127
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            205..243
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            244..370
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
     exon            371..4323
                     /gene="Zfp418"
                     /gene_synonym="RGD1311663; ZNF418"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcgtc ctgtctttgg tttaacttcc catgggttgg tatttggagg attctgagct
       61 ttaggatcgc caaattatac tcaagttaag agagagagcc ggcgcaggat gaaggccaag
      121 aagaccgtag gcagcagcgg tagctgtgtc cgggcccctg cgttgtcaac agagccgatg
      181 gcggctgtga agcacctggc tcagattccc agatgtacag aaacgggtat gatctgtaca
      241 cagggctgtg taaccattga ggacgtgact gtttacttct cccaggaaga gtggaagctc
      301 ctggatgaag ctcagaggct actgtatctt gatgtgatgc tggagaattt tacccttata
      361 tcctcactgg tttatcggta tgaagcagag gctgaagaaa aaacctgtgc acagagtctt
      421 tcacaaactg aagcaccaca agtcaggact ccgaagcaag gtcaactcag gcagaagcct
      481 catccctctg acatctgtat caccgtcctg aaagatatct tgcatctgaa cgacctacct
      541 gggcaaaagc cgtatttgac cgaagtgtgt acaaagcccc aggaccataa gcatcacaga
      601 gccaagaatt ggttaaagag agacgtggac tcccttgtga agagctgtat attccatgtg
      661 gcagggaacc ctttcatctg tagtaagatt ggagagaaat tcccagctat atggaatctt
      721 ctccaaccca aggacatccc caacggtgag aaacaaaata aaattaagcg tggaaaggct
      781 tttcacaggg ataaaaataa ttctgaatca gatgaatata agaaatcttc cagcccccaa
      841 cacaggcttc atgaataccc aggagtttgc agtgcaaagg ggggttttga atctaacagt
      901 tgtgagcaag acttaaacaa gtactcacct gcaccattcc ggatggacca gactgaaaac
      961 cgaccatatg agtgtcatgt ctgtggaaaa tggtttggcc agaaagccac acttagaata
     1021 caccagagac gtcataccgg agaaaaacca tataagtgtg gtgaatgtgg aaagtctttt
     1081 tgtcaaagct ctaacctaag tgaacactgc agagttcata gtggagaaag accttttgag
     1141 tgtctggaat gtgggaaagc ctttgggtgc cattctagtc ttctgcggca ccagagaaca
     1201 cacactggag aatggccata tgaatgcagt gactgtggga gactgtttag acagattgtc
     1261 agcctgatta cacaccagag gactcacact accgagaagc cttatgaatg tggacagtgt
     1321 gagaagtctt ttagtcacaa agccactctt actgtacatc agagagttca cactggggaa
     1381 aagccctatc actgtgaagc ctgtgggaaa tccttcagcc aaagtgccaa ccttattaaa
     1441 cactccaaaa ttcacactgg agaaaagcct tatgagtgtg gagaatgcgg tctatgcttt
     1501 cgccagagag ctaccctcat gaaacaccag agaacccaca cgtcagaaag gccttatgaa
     1561 tgtagagaat gtggtaagtt ctttaaacaa tacttctacc tcattgaaca ccgtaggatt
     1621 cacaccacaa cagaatttta tgagtgtgaa cagtgcggga agtcttatac ccaaaaagcc
     1681 acccttatca gacaccaacg agtccacaca ggagagagtc cttataaatg tgaggagtgt
     1741 ggaaaagcct ttgaatacaa atccagactt aagcgacatc aaagaacgca cactggtgaa
     1801 aggccttatg agtgtgccaa atgtgggaaa ttcttcagag aaagctacaa tcttgctgaa
     1861 caccagaaaa ttcacactaa agcaaagcct taccattgtg atcagtgtgg gaagtgtttt
     1921 agccggagag ctgacttggt taaacaccag agagttcaca ctggtgaaag accttatact
     1981 tgtggtgaat gtgggaagac cttcagccga actaccaacc ttgttcaaca cagaagaatt
     2041 cacactgggg aacggccata cgagtgtgac cagtgtggga aatcttttag ccaggtgtct
     2101 accctcactc gacatcagct acttcacact ggagaaaaac cgtataagtg tagcaaatga
     2161 aggaaagtct agacagccct ctagcatctt ctaacaccaa aagatagacc atcacagctc
     2221 ccggaagcca acccttgaaa gcaccctcag gcctccaagg atattacatt gttcactgta
     2281 acaaactaga gagcctcata gagttctagg tcatgtaatt tgtaccagag ctagcctgca
     2341 tgttctggac agtctgtacc ccttgccaga gttaaagagc tgtcataatg tctcatagac
     2401 actgtctctt ctctagcacc ttgcactgag tgcatatgca ccaccaccac cccaccccac
     2461 ccttgcaaca tgccgtactc tccccttccc taatagaagc ctcaacttcc tgtgccttgc
     2521 aaatgacctt gatccctttt tctcactgga tatttctggg tctgtatttt gcctaaagga
     2581 acatggtctg ggatgagtgg gaggctccag caaggattat cttctcaagt ctgtctcaca
     2641 tgattcgtgt gactgtttac atactccaaa tcactagcca ggaacttcct gtcaggatgt
     2701 gcaataataa aagaccttat ttttttttcc cccatgtact tttaatcaag agtttctatt
     2761 cacagactta ggcagccaaa atactatgat aggtcctgtt tttgttttgt ttaattattt
     2821 ttatttacat tcaagccgtt gccttccatc acctctccct caagtcttca tccccctcct
     2881 ttttctcctt gccttcaaga gggtgcccct gccaccaggc ctcccccttc cctggtgcct
     2941 caagtctctc aaggcgtatc ttctcccact gaggccagac cacgcagtcc tctgatatat
     3001 atgtgctagg ggttgcctgt ttggtaggct ctgtttatat agaaattgta acagtgtttg
     3061 ggttttttat ttaatattta tttattgaat gtacatgtgt gctctgtctt catgcacacc
     3121 agaagaggga atcaattctg agccatcatg tggttgctgg aattgaactc aggccctcca
     3181 gaagatcagc cagtgctctt aacatctgag ccatctctcc ttccctggaa caggtcttga
     3241 ggctgcacca ttcatgcctc agcatgggta atgggaaaga gtagctctcg tttatgttgc
     3301 tttccaaaac ctttagtgga acaaagcagg gtgttcagtc ctagctttgt gctttttttg
     3361 tttgttgttg ggaggaaggt gttttgtttt tagactaccc tgaggtcact tgttggaact
     3421 gcaacattca gtgctcttag aatagcttta acttatccca tcattcccac atggtctgac
     3481 ctgattatgc ccaagattgt cgaagagaaa cttttctatg aggttcatag acaccaagtc
     3541 cataattcca aatgtcactt gaaaaattag gagaaccaaa taggaacaat aacgggtaga
     3601 ttaatacaag ctttaagggt cggagaggtg gctcagcagt taagagcacc cgactactct
     3661 tccagaggtc ctgagttcaa ttcccagcaa ccacatggtg gctcacaacc atctgtaaag
     3721 agatccgatg tcctcttctg ttgtatctga agacagctca gtgtacttat ttataataaa
     3781 tgaataaatc ttttttaaaa aatacaggtt ttgataattg aaaggtgggg ttttatatga
     3841 gaacattacc tggggattga ttactctaga gaccacagat attgcattct ggaaaataat
     3901 ttgcctgtat cttgtgtcct gaaatcttaa ctgagtctga attcatgctg taacttatag
     3961 ccagatttac agtgagcaac atcagcaaaa cgccaatcag aaagattcaa aagcaggcag
     4021 ttttgccagg aacagaatgt attgggagat acaaagaagc catagttact aatgggatca
     4081 cactgttaaa agaaactaag tactttgtac taggggtgta gaaaaataat aaagatacct
     4141 tgatggctca gcttctcttc cagagatcct gagttccatt cccaggaact gcatggtggc
     4201 tcacaagcat ttattaagga atctgatgcc ctcttctggt atgtaggtgt atgtgcagat
     4261 agcactcact tataaataaa taaataaata aataaataaa taatttttaa tttgttttaa
     4321 aaa
//
LOCUS       NM_001438229            3674 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus SPOC domain containing 1 (Spocd1), mRNA.
ACCESSION   NM_001438229
VERSION     NM_001438229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3674)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2457133.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1485              JAXUCZ010000005.1  147552125-147553609
            1486-1626           JAXUCZ010000005.1  147571661-147571801
            1627-1684           JAXUCZ010000005.1  147572246-147572303
            1685-1763           JAXUCZ010000005.1  147572512-147572590
            1764-1920           JAXUCZ010000005.1  147573460-147573616
            1921-2037           JAXUCZ010000005.1  147573736-147573852
            2038-2163           JAXUCZ010000005.1  147576047-147576172
            2164-2347           JAXUCZ010000005.1  147577812-147577995
            2348-2498           JAXUCZ010000005.1  147578149-147578299
            2499-2634           JAXUCZ010000005.1  147578619-147578754
            2635-2724           JAXUCZ010000005.1  147579112-147579201
            2725-2911           JAXUCZ010000005.1  147579649-147579835
            2912-3674           JAXUCZ010000005.1  147580534-147581296
FEATURES             Location/Qualifiers
     source          1..3674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3674
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="SPOC domain containing 1"
                     /db_xref="GeneID:313060"
                     /db_xref="RGD:1560989"
     exon            1..1485
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    625..627
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="upstream in-frame stop codon"
     CDS             658..3543
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="SPOC domain containing 1, pseudogene 1; SPOC
                     domain-containing protein 1"
                     /codon_start=1
                     /product="SPOC domain containing 1"
                     /protein_id="NP_001425158.1"
                     /db_xref="GeneID:313060"
                     /db_xref="RGD:1560989"
                     /translation="MEGASSPSLRQAITVEGMVSPKGDGRVPTHSKEGLSEKDLPPSP
                     VLPPRRSRRKCRKCSICPQDEEESYFSLKLGQRPSGDCQPVQGPPERAPPEAFAGPQS
                     LLSSKNTGLEEPAGSWAECALESEVENMFFAKDVLPPDSLDHLFEFPGLFAGEPLSLV
                     TQDPPQSPALYPEVLTGDSTKQQKAQSGFVVGSPGTPPHPERPEDKAQPGSRMELGQG
                     LATPADFCASSLEPLGGLDGASQEQRRPKHVNKRPWGSPDNSSQDHPEEARKNDCSRP
                     VCSGSGIKLLGAVSSRQPGQTEPMEELKASSARRKRKPMTAHPACCQSDPSEAENVQP
                     LQQRAEDPGEREIMPLDVGVRSTVVRAMQEVLWTRTQELPNLELREDEVEGIAEGIEA
                     ALFHLTQDTNLRYKSKYRNLLFNLRDPRNDLFLKVAHCDVTPKDLVQMSSIQLAPKEL
                     SRWRDQEKRRSLDIIEQQQKEPYRLPASKLTHKGEVEIPRDSDQMLTLEDLMEPMVPR
                     ECSLQALTTPLEDTTDWHQHHLCDSSCQICTGGKGGRKADSGSQPELQAGISHSMDQK
                     SSTKLPAFSPAAMNEEENTIQKAPSPVPVSSPEMLKVGKTPPKEPQDRLQMPAGPKPV
                     PPSPPPWEGSLDMFSIKHFRTKAQLISGHSCQLVQGLPEVIRSAGRLPPNHIWDLLDS
                     MGPSRAKDICVVRLSPHGSRDIQNYRLLYSYLNDKQCHCLATVHHVKMVLMPLPAFEP
                     LPARLRPLGGPGLETAHTSLLLAVLFPEDELPDTALSSPVWSKAPKTVSFSKKVERIR
                     YSSEDRRSEATPRGPSPHEEEPKQSLAQGNLAPRSVCAPQSLSRGRGSEPGWGQWSSE
                     AGWHYSQHYSQHPNPAGPMFPGISRGQHLHRASCFHHDLHQHLKVLVTMSHQFQASLR
                     PQGQDSCLPSTVVSVVPDPPGSSSGPLDGGGSGCPLPEGPDPLELPE"
     misc_feature    1717..2046
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="Transcription factor S-II (TFIIS), central domain;
                     Region: TFIIS_M; pfam07500"
                     /db_xref="CDD:462184"
     misc_feature    1717..2046
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="Transcription factor S-II (TFIIS), central domain;
                     Region: TFIIS_M; pfam07500"
                     /db_xref="CDD:462184"
     misc_feature    2548..2958
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="SPOC (Spen paralog and ortholog C-terminal) domain
                     superfamily; Region: SPOC_SF; cl45902"
                     /db_xref="CDD:459247"
     misc_feature    2548..2958
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /note="SPOC (Spen paralog and ortholog C-terminal) domain
                     superfamily; Region: SPOC_SF; cl45902"
                     /db_xref="CDD:459247"
     exon            1486..1626
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1684
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1763
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1920
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2037
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2163
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2347
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2498
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2634
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2724
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2911
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3674
                     /gene="Spocd1"
                     /gene_synonym="RGD1560989; Spocd1-ps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccctgccc ctcgggagta gaaagggaag gagctgtagc atctcaggag taagcggttt
       61 ggagttttag gcctgagacc cttcggcagt cagggactgg cttgactcag agtggggtct
      121 ataggagtgg agtatagggc tgatggtttc tgctccgtgt agagtttcga gctggccttt
      181 gcatttctgg gagaatctcc tcctttcggc tctctgtgtg ctcttgggca gtctctgaat
      241 cagctaggat aaggcgagat acctcatttc acagtgtcac tgataagtac tgacttttac
      301 cctattccat ttaagcagaa agcttaaagg gtaaaaaagc tctgggaaag ctcagaggca
      361 ctggccgtat ctggatagct ttccttctgc ggggcagggc gcgggagtgg gggagcactt
      421 ctaggaggtg aggttgccag tccgggagga ctatccagtc aggctttcct tgagaccttc
      481 ctcttttcca cagaagccta ttgaccagct tttggccagg gctggtggac agaggacctt
      541 gtctaggttc caggactctc tgtgtgactt tctggctacg agaagctcca gaaatctttg
      601 tgatacatca ctgggcttct caagtagaat actgcctgta cagaggggcc atcagggatg
      661 gaaggggcca gtagccccag ccttagacaa gccatcacgg ttgaagggat ggtttcccca
      721 aagggtgatg gaagagtccc tacacacagc aaagaggggc tcagtgaaaa ggacctgccc
      781 ccctctccag tcctgccccc tcggaggagc cgaagaaaat gcaggaagtg tagcatctgt
      841 ccccaggatg aggaggagtc atacttttcc ttgaagcttg gtcagagacc gtctggcgac
      901 tgccagcctg tgcaaggccc tccggaaaga gctcctccag aggcctttgc tggtccccaa
      961 agtcttcttt cttccaagaa cactgggctt gaagagcccg ctggaagttg ggcagaatgt
     1021 gctctagaat ctgaggttga aaacatgttc tttgccaagg acgtgcttcc gccagacagc
     1081 ctcgaccacc tttttgaatt cccagggctc tttgcaggtg agccccttag tctggtcaca
     1141 caggatcccc cccagagtcc agcactgtac ccagaggtgc tgaccgggga ttctacaaag
     1201 cagcagaaag cacagtccgg gtttgtggtt ggcagccccg gcactccacc tcacccggag
     1261 aggccagagg acaaggccca gccagggtcc agaatggagt tggggcaagg acttgctact
     1321 ccagctgatt tctgtgccag ctccctggag cccttgggtg ggctcgatgg tgcatcccag
     1381 gagcagagaa gacccaagca tgtgaataaa cggccttggg gaagtccaga caactcaagc
     1441 caggatcacc cagaggaagc caggaaaaat gattgctcta gaccggtctg ctctgggtca
     1501 gggatcaagc ttctgggagc cgtcagcagc aggcagccag gacaaactga acctatggag
     1561 gagttgaagg ccagctcagc caggaggaag agaaagccca tgactgctca cccggcctgt
     1621 tgtcagagtg acccttcaga agcggagaat gtgcagcctc ttcagcagag ggcagaggac
     1681 ccaggtgagc gggagattat gcctctggat gttggagtgc gatccactgt ggtccgtgcc
     1741 atgcaggagg tactgtggac tcgcacccag gagcttccca acctggagtt gagggaagac
     1801 gaggtggagg gcattgcaga aggcattgag gctgccctct tccacctgac ccaggacacc
     1861 aacctccgct acaagagcaa gtaccgtaac ctgctcttca acctgcggga tccccgaaat
     1921 gacctgtttc tcaaagtggc tcactgtgat gtcaccccta aggacctggt acagatgagc
     1981 tcaatccagc tggccccgaa ggagctgtcc cgctggcggg accaggagaa gagaaggagc
     2041 ctggatatca ttgagcaaca acagaaggaa ccgtacaggc ttcccgcctc caaactgact
     2101 cacaagggcg aggtagagat ccctcgggac tcggaccaga tgctgacctt ggaagacctg
     2161 atggaaccca tggtgcccag agagtgcagc ctacaggccc taacgacccc cctggaggac
     2221 accacagatt ggcatcagca ccacctctgt gactccagct gccagatctg cacgggtggg
     2281 aagggaggca ggaaggctga cagtgggagc cagccagagc tacaagctgg catcagccac
     2341 agcatggatc agaaatcctc aactaaactg ccagccttct ccccggccgc catgaacgag
     2401 gaggaaaaca ccatccagaa agccccaagt ccagttcctg tgtcctctcc agagatgctc
     2461 aaagttggga agacaccccc taaggaacca caagacaggc tccagatgcc tgctgggccc
     2521 aaacctgtcc cgcccagccc tccgccctgg gagggttcac tggacatgtt ctccatcaag
     2581 cacttccgga ccaaggcgca gctgatctcc gggcacagct gtcagcttgt ccagggtctg
     2641 ccagaggtca ttcgctcagc aggccgcctc cctccaaacc acatctggga tcttctagac
     2701 agtatgggcc catccagggc aaaggacatc tgtgtggtca gattgagtcc ccacgggtct
     2761 cgggacatcc agaactaccg tttgctctac tcctacctca acgacaagca gtgccactgc
     2821 ctggcgaccg tgcatcatgt gaaaatggtc ctgatgccct tgcctgcctt tgagcctctg
     2881 ccagccaggc tgcgccctct ggggggccca ggtcttgaaa ctgctcacac gagcctgtta
     2941 ctggctgtgc tgttcccaga ggatgagctt ccagacacag ctctgtccag ccccgtgtgg
     3001 agcaaggctc caaagaccgt gtctttcagc aaaaaggtgg aaaggatccg atactcatca
     3061 gaggacagga ggtcagaggc caccccgaga ggaccatctc cccatgagga ggagccaaag
     3121 cagagcttgg cccagggcaa cctggctcca aggagtgtgt gtgctccaca gagcctctcc
     3181 agaggcaggg gaagtgagcc tgggtgggga cagtggtcct cagaagcagg ctggcactac
     3241 tcccagcact actcccagca tcccaatcca gcaggaccca tgttccctgg catcagccgt
     3301 ggacagcacc tccacagggc ctcctgtttc caccatgacc tacaccagca cctcaaggtc
     3361 ttagtgacca tgagtcacca gttccaggcc tcactgaggc cccaaggcca ggattcctgc
     3421 ctcccatcta ccgtagtatc tgtagttcca gatccccctg ggtcttcttc aggccctttg
     3481 gatggaggtg gctctggctg tcccctgcca gaggggcctg accctttaga gcttccagaa
     3541 taggagtgtt gaatcctttc ccaatgctga accccaggaa cgacaagtga gctctcccac
     3601 acctgcccag tttgtgtctg ttctgcagtc tgtttgatgt tgatttttgg ttcaataaaa
     3661 acttggcaaa gtaa
//
LOCUS       NM_001431827            1746 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus ankyrin repeat domain 53 (Ankrd53), transcript
            variant 2, mRNA.
ACCESSION   NM_001431827
VERSION     NM_001431827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Kim,S. and Jang,C.Y.
  TITLE     ANKRD53 interacts with DDA3 and regulates chromosome integrity
            during mitosis
  JOURNAL   Biochem Biophys Res Commun 470 (3), 484-491 (2016)
   PUBMED   26820536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160898.1, SRR26643293.23664.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               JAXUCZ010000004.1  117804556-117804964
            410-539             JAXUCZ010000004.1  117805051-117805180
            540-739             JAXUCZ010000004.1  117805477-117805676
            740-904             JAXUCZ010000004.1  117807490-117807654
            905-1025            JAXUCZ010000004.1  117808055-117808175
            1026-1746           JAXUCZ010000004.1  117809930-117810650
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1746
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /note="ankyrin repeat domain 53"
                     /db_xref="GeneID:500230"
                     /db_xref="RGD:1561200"
     exon            1..409
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    144..146
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /note="upstream in-frame stop codon"
     exon            410..539
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
     exon            540..739
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
     exon            740..904
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1025
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
     CDS             921..1682
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /note="ankyrin repeat domain-containing protein 53"
                     /codon_start=1
                     /product="ankyrin repeat domain 53"
                     /protein_id="NP_001418756.1"
                     /db_xref="GeneID:500230"
                     /db_xref="RGD:1561200"
                     /translation="MWKHDKKVFAREMERLKTLKKKLTIMEYRYLTEFQKEQQIMRED
                     LFRKWLQSKVLARTLGSAVSKQNASVQPWSLASKTLEHQIIKSFQYPSIEAQLKSLPS
                     PMVPPKPVYKQSKISRPKIWNCSANPSRPRITDIGHPQGIRLGVHPEPYKEHDFCRFL
                     EMTRNKLGGACLRTVDCQLVKPVPQLPFEVMIRVLYPGTRPYRMKVPQGFYARDILKV
                     PQKRHLGDTCTNTVAMSLRDTFDEPFLASLEACQT"
     exon            1026..1746
                     /gene="Ankrd53"
                     /gene_synonym="RGD1561200"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttggcgcc gagccctgct ttctataagc agagatggag acaattcatt taccagttgc
       61 cctttccgtt tcatctctgt gattccaata gaggctaagc ccggggtgca gagttcccag
      121 gattgcaaac ttcgtccctt ccttgagtcc tggctggggc cgcggatggc agaggctctg
      181 ccccgaaggc ggggacgggg gcgggtcgag tgcgacgcca cttgaggcgt cggtctaatg
      241 ccgctacacc ccccaggagc cgcaccactc cccgcagaac tggggccttg gattccagag
      301 ggcaacaggg gagaaaagag cagtcccgcc tctctgcaca gggaagcaca ctgcaggcag
      361 aacacaactc gaaggttcct agcagcgacc ccgaatcctc gcagatcagt acctccgaat
      421 cgtggaacca aaaagtgatc gcgacctact ccgagttttt cgctgcctcg gtgggcaatg
      481 tggattggct tcggttctgt gtgaatccgg aacgcaagga ggtcgtagtc gacgacaagg
      541 ggttcacagc catccacttc gcagcccaga aatgccagct ttcctgtctt aaggtcttga
      601 tagaggagta caaatatcct gtggacctgc ccaccaataa aggccagacg cccctgcacc
      661 tagtcatcca taaaaacaac aggtcggaca ttatcccctg cgttgactac ctgctcaaga
      721 aaggggcagc catcaactcg cagacatgta acggctccac acccctgcac ctggcttcta
      781 tcagtggcat tctgggatgt attaagctgc tggtgcagaa tggagccaat gtgcacgccc
      841 aagatgccat aggcttcaag cccatcgact actgcagact gtggaaccac cgtacctgtg
      901 cccggttctt gaaggatgcc atgtggaaac atgataagaa ggtctttgcc cgagagatgg
      961 agagactgaa gactttgaag aagaagctga ccattatgga gtatcgctac ctgactgagt
     1021 ttcaaaaaga acagcaaatt atgagagagg atcttttcag aaagtggctc caaagcaagg
     1081 tgctggcccg gaccctgggc tctgctgtct ccaagcaaaa tgctagtgtc caaccttggt
     1141 cattggcctc caagacttta gaacaccaga ttattaaaag cttccagtat ccatctatag
     1201 aagctcagct gaaaagcttg ccctcaccca tggtgccacc caagcccgtc tacaagcaga
     1261 gcaaaatcag tcggcccaag atatggaatt gtagtgctaa cccttccagg ccccggatca
     1321 cagatattgg ccacccacag ggtatacgcc tgggtgtgca cccagaaccc tataaggagc
     1381 atgacttctg cagattcctg gagatgactc gaaataaact tgggggtgca tgcctgcgca
     1441 cagtggactg tcaattggtg aaacctgtac cccagctgcc ttttgaggtg atgatccggg
     1501 tgctgtaccc agggactcga ccctacagga tgaaagtgcc ccagggcttc tatgcacgtg
     1561 acatactcaa agtgccccag aaacggcact tgggagatac ttgtaccaat acagtggcca
     1621 tgagcctacg tgacacattt gatgaaccct tcctagcttc cctggaagct tgtcagactt
     1681 gagaggcctc accctccaag caagttctca cataaagttg ttctggaagc tgtggtaaag
     1741 gagaaa
//
LOCUS       NM_001429701            3395 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant
            4, mRNA.
ACCESSION   NM_001429701 XM_063288329
VERSION     NM_001429701.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Smereczanska,M., Domian,N., Lewandowska,A. and Kasacka,I.
  TITLE     Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid
            receptors in the adrenals of hypertensive rats
  JOURNAL   J Cell Mol Med 28 (10), e18376 (2024)
   PUBMED   38780511
  REMARK    GeneRIF: Comparative assessment of CacyBP/SIP, beta-catenin and
            cannabinoid receptors in the adrenals of hypertensive rats.
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Kang,H., Jiang,S., Song,Q. and Zhang,Y.
  TITLE     [Activation of cannabinoid receptor 2 alleviates acute lung injury
            in rats with lipopolysaccharide-induced sepsis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1374-1380 (2022)
   PUBMED   36210711
  REMARK    GeneRIF: [Activation of cannabinoid receptor 2 alleviates acute
            lung injury in rats with lipopolysaccharide-induced sepsis].
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Karan,A.A., Spivak,Y.S., Gerasimov,K.A., Suleymanova,E.M.,
            Volobueva,M.N., Kvichansky,A.A., Vinogradova,L.V. and
            Bolshakov,A.P.
  TITLE     CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex
  JOURNAL   Mol Neurobiol 58 (8), 4028-4037 (2021)
   PUBMED   33907944
  REMARK    GeneRIF: CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex.
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   Gigante,I., Tutino,V., Russo,F., De Nunzio,V., Coletta,S.,
            Armentano,R., Crovace,A., Caruso,M.G., Orlando,A. and
            Notarnicola,M.
  TITLE     Cannabinoid Receptors Overexpression in a Rat Model of Irritable
            Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
  JOURNAL   Int J Mol Sci 22 (6), 2880 (2021)
   PUBMED   33809047
  REMARK    GeneRIF: Cannabinoid Receptors Overexpression in a Rat Model of
            Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic
            Diet.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3395)
  AUTHORS   Esposito,G., Ligresti,A., Izzo,A.A., Bisogno,T., Ruvo,M., Di
            Rosa,M., Di Marzo,V. and Iuvone,T.
  TITLE     The endocannabinoid system protects rat glioma cells against HIV-1
            Tat protein-induced cytotoxicity. Mechanism and regulation
  JOURNAL   J Biol Chem 277 (52), 50348-50354 (2002)
   PUBMED   12388547
  REMARK    GeneRIF: protects rat glioma cells against HIV-1 Tat
            protein-induced cytotoxicity
REFERENCE   7  (bases 1 to 3395)
  AUTHORS   Brown,S.M., Wager-Miller,J. and Mackie,K.
  TITLE     Cloning and molecular characterization of the rat CB2 cannabinoid
            receptor
  JOURNAL   Biochim Biophys Acta 1576 (3), 255-264 (2002)
   PUBMED   12084572
  REMARK    GeneRIF: The rat peripheral cannabinoid receptor (rCB2) was cloned
            from a Sprague-Dawley rat spleen cDNA library and when translated,
            encodes a protein of 410 amino acids.
REFERENCE   8  (bases 1 to 3395)
  AUTHORS   Clayton,N., Marshall,F.H., Bountra,C. and O'Shaughnessy,C.T.
  TITLE     CB1 and CB2 cannabinoid receptors are implicated in inflammatory
            pain
  JOURNAL   Pain 96 (3), 253-260 (2002)
   PUBMED   11972997
  REMARK    GeneRIF: CB1 and CB2 cannabinoid receptors are implicated in
            inflammatory pain.
REFERENCE   9  (bases 1 to 3395)
  AUTHORS   Carlisle,S.J., Marciano-Cabral,F., Staab,A., Ludwick,C. and
            Cabral,G.A.
  TITLE     Differential expression of the CB2 cannabinoid receptor by rodent
            macrophages and macrophage-like cells in relation to cell
            activation
  JOURNAL   Int Immunopharmacol 2 (1), 69-82 (2002)
   PUBMED   11789671
  REMARK    GeneRIF: levels of the cannabinoid receptor type 2 in cells of
            macrophage lineage undergo major modulatory changes in relation to
            cell activation
REFERENCE   10 (bases 1 to 3395)
  AUTHORS   Griffin,G., Tao,Q. and Abood,M.E.
  TITLE     Cloning and pharmacological characterization of the rat CB(2)
            cannabinoid receptor
  JOURNAL   J Pharmacol Exp Ther 292 (3), 886-894 (2000)
   PUBMED   10688601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 25, 2024 this sequence version replaced XM_063288329.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.8168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000005.1  153409184-153409403
            221-315             JAXUCZ010000005.1  153427055-153427149
            316-3395            JAXUCZ010000005.1  153432013-153435092
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3395
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
     exon            1..220
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..315
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    249..251
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="upstream in-frame stop codon"
     exon            316..3395
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1448
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     peripheral cannabinoid receptor; CB2 receptor; cannabinoid
                     receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2 isoform 1"
                     /protein_id="NP_001416630.1"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
                     /translation="MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMG
                     LLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDS
                     RNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQ
                     HVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDK
                     VKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPK
                     SSVTETEAEVKTTTGPGSRTPGCSNC"
     misc_feature    396..398
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); glycosylation site"
     misc_feature    465..1295
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    465..1295
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    465..542
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    468..548
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    468..548
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    570..647
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    570..647
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    579..641
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    order(633..635,690..695,702..707,714..716,945..947,
                     1137..1139,1158..1160,1209..1211,1218..1220)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    order(633..635,690..695,702..707,714..716,945..947,
                     1137..1139,1158..1160,1209..1211,1218..1220)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    678..752
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    681..773
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    681..773
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    807..869
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    807..869
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    813..881
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    921..1010
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    921..1010
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    930..1007
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1077..1169
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    1077..1169
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    1104..1166
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1197..1274
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1197..1274
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1203..1268
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1344..1445
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1368..1370
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1371..1373
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1377..1379
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1419..1421
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P34972; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
ORIGIN      
        1 gacactgggg actcagaggg gaagtggtaa cagggacaga cggaaggcca gacctcctct
       61 cacccactca tctacaaaag tgtaaaagca agaaaaacca ggctggggct gcagctccct
      121 ggacctacgt ggtggtcctg tccaggtctc cagatctaaa tacaaaatag ccaggacaag
      181 gcttcacaag accctggagg ccagcggctg acaaatgact gaacagctgt ctgcagccac
      241 gccgcgcctg agtgaggaga ggcgtaggca ccagccgagg ccacccagca aacatctatg
      301 ctgactctga atgggcccag tcctccggaa cagctccggt agaagcagcc aaagcctgtc
      361 tgtccatggc gggatgccgg gagctggagt tgaccaacgg ctccaatggc ggcttggagt
      421 tcaaccctat gaaggagtac atgatcttga gtgatgcgca gcagatcgct gtggcggtgc
      481 tgtgtaccct gatggggctg ctgagtgccc tggagaacgt ggctgtgctc tatctcatcc
      541 tgtcctcgca gcggctccgc aggaagccct cgtacctgtt catcggcagc ttggccggag
      601 ctgacttcct ggccagcgtg atctttgcct gcaacttcgt catcttccat gtctttcacg
      661 gtgtggactc caggaatatc ttcctgttga agatcggcag cgtgaccatg accttcacgg
      721 cctctgtggg cagcctgctg ctgaccgctg ttgaccgata cctatgtctg tgctacccac
      781 ctacctacaa agctctcgtc acccgtggga gggcactggt ggcccttggt gtcatgtggg
      841 tcctctcggc gttgatctcc tacctaccgc tcatggggtg gacttgttgt cctagtccct
      901 gttctgaact tttccccctg atccccaacg actacctcct gggctggctt cttttcattg
      961 ccatcctctt ttctggcatc atctatacct atgggtatgt cctctggaaa gcacaccaac
     1021 atgtagccag cttggctgag caccaggaca ggcaggtgcc tgggatagct cggatgcggc
     1081 tagacgtgag gttggccaag actctgggcc tggtcatggc tgttctgctc atatgctggt
     1141 tccctgcact ggctctcatg ggccatagcc tggtcaccac actgagtgac aaggtcaagg
     1201 aggccttcgc cttctgctcc atgctgtgcc ttgttaactc catgatcaat cctatcattt
     1261 atgccctgcg gagtggagag atccgctctg ctgcccagca ctgcctgaca ggctggaaga
     1321 aatatctcca gggcctcgga tctgagggga aagaagaagc cccaaagtcc tcagttacag
     1381 agacagaggc tgaggtgaaa accaccacag ggccgggatc cagaacacca ggctgctcca
     1441 attgctgata cggcctgtct ttctttcttt cttttttttt tttttttaaa gatttattta
     1501 tttattatat ataagtacac tgtagctgtc ttcagataca ccagaagagg gcatcagatc
     1561 tctttacaga tggttgtgag ccaccatgtg gttgctggga tttgaactca ggacctctgg
     1621 aaaagcagtc gggtgctctt aaccactgag ccatctctcc agcccacggc ctgtctttct
     1681 atggaagcag tccgactcag aagtcaggtc actccctcca gaagagaggg gtcctggacc
     1741 ctgaatattt ctgaagccag ctctagggta atggaaacag aacttcccac cccctttttt
     1801 gctaaggagt gctggggttc atggctggaa gacggcctgg tcttgcctac cttacgcagt
     1861 ctgtggagag gggcctgtaa aaatggcggg ctctgttcac atcaaatcgg gaaaccctcc
     1921 tgactccaga gacctagagg ccagaggggc ctccagggac gataatgaag gactcagggg
     1981 atctgtgaag acaagggacc tgttctcctg gaatctaggc taccccggct gtgaggcctc
     2041 tgcccacaac ttcacagatg tccatatctt ccacagtgtg ggttctaggc cgccctgctg
     2101 aagatggata gcaagaccag ctatttctgg ttcctgcttc actgattgga actctgtggc
     2161 tgtagagcga tgtgaccttc aggccaccct tgcctcttga ggatcaagaa ttatgatgtg
     2221 ctgaggacca aggaggttca ctctctccct tcagacagag ccatgtgctg tcagctcagg
     2281 gtatcttgtt gttggaacag gaccctcctg atagcccgat aagccttgaa aatcattatg
     2341 actttaggtc cttggggacc cacgggaagc caggttcact tgaggtacag agtcctcaga
     2401 gaactgtatg gaccttgtga ccttctgctg tgtctcccat agcactatcc cagtccagcc
     2461 tagcttcagt aaaaatcaag gtattcacaa agagtctttg ggttctagat tgttcctagt
     2521 gatgctcaac tcagcttccc ttgcctcttc cagactctgg tcctgaagga taagcaggag
     2581 ttgggaggag actgcctgct gcggacatcc tcgatccaca gccccatgct gtctctgggt
     2641 acctgcattt taccttcagc aaaggttgca ttcccaacag acggaggttc aaggcgctgc
     2701 tggtggtagg ggtaggtagc actggggacc gaagacacgg tgaaaggaaa accctcaaac
     2761 actttctact tttgctttta gcagattcag ccaacagaca agacgtccgt ccccattgcc
     2821 cagaggaact aacatggtgg tgttcagtga gaagaccaat cagcctccct aataaagcag
     2881 ggcagtccac tctgctataa accctctcac atgcctctgc aggaggacat tttgttttct
     2941 ctgttaaggt caagtgaagg tcacagtgtc tcattttatt cttcccaaga caagttctgt
     3001 gcatcaaaag ctgctgcaaa ttctactcta atcgctatgt gggaggactc ggggaagaag
     3061 ttgattcgtc tgggctttgt gttttagacc gtatttcaac atacacttgg gaaggaagaa
     3121 acagaaaata cattgtgttt ccttgttact ccccaaagga ggaagtgctt ggttctgtca
     3181 acttcaacag atttctccaa ggtgccagac agagaaggtg gagatacggt ttccgcagct
     3241 gtgaattccg gcaccacctt tggccctcac ttgcttgtgt gatcttgggc aacccctgcc
     3301 ctttgccttg ctttggtttc ctccttggta catcgggaat ggtaggaaag aagatgcctt
     3361 caaggggcat tcattaaaac ctggtattgc tctaa
//
LOCUS       NM_001164142            3202 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant
            2, mRNA.
ACCESSION   NM_001164142
VERSION     NM_001164142.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3202)
  AUTHORS   Smereczanska,M., Domian,N., Lewandowska,A. and Kasacka,I.
  TITLE     Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid
            receptors in the adrenals of hypertensive rats
  JOURNAL   J Cell Mol Med 28 (10), e18376 (2024)
   PUBMED   38780511
  REMARK    GeneRIF: Comparative assessment of CacyBP/SIP, beta-catenin and
            cannabinoid receptors in the adrenals of hypertensive rats.
REFERENCE   2  (bases 1 to 3202)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   3  (bases 1 to 3202)
  AUTHORS   Kang,H., Jiang,S., Song,Q. and Zhang,Y.
  TITLE     [Activation of cannabinoid receptor 2 alleviates acute lung injury
            in rats with lipopolysaccharide-induced sepsis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1374-1380 (2022)
   PUBMED   36210711
  REMARK    GeneRIF: [Activation of cannabinoid receptor 2 alleviates acute
            lung injury in rats with lipopolysaccharide-induced sepsis].
REFERENCE   4  (bases 1 to 3202)
  AUTHORS   Karan,A.A., Spivak,Y.S., Gerasimov,K.A., Suleymanova,E.M.,
            Volobueva,M.N., Kvichansky,A.A., Vinogradova,L.V. and
            Bolshakov,A.P.
  TITLE     CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex
  JOURNAL   Mol Neurobiol 58 (8), 4028-4037 (2021)
   PUBMED   33907944
  REMARK    GeneRIF: CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex.
REFERENCE   5  (bases 1 to 3202)
  AUTHORS   Gigante,I., Tutino,V., Russo,F., De Nunzio,V., Coletta,S.,
            Armentano,R., Crovace,A., Caruso,M.G., Orlando,A. and
            Notarnicola,M.
  TITLE     Cannabinoid Receptors Overexpression in a Rat Model of Irritable
            Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
  JOURNAL   Int J Mol Sci 22 (6), 2880 (2021)
   PUBMED   33809047
  REMARK    GeneRIF: Cannabinoid Receptors Overexpression in a Rat Model of
            Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic
            Diet.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3202)
  AUTHORS   Esposito,G., Ligresti,A., Izzo,A.A., Bisogno,T., Ruvo,M., Di
            Rosa,M., Di Marzo,V. and Iuvone,T.
  TITLE     The endocannabinoid system protects rat glioma cells against HIV-1
            Tat protein-induced cytotoxicity. Mechanism and regulation
  JOURNAL   J Biol Chem 277 (52), 50348-50354 (2002)
   PUBMED   12388547
  REMARK    GeneRIF: protects rat glioma cells against HIV-1 Tat
            protein-induced cytotoxicity
REFERENCE   7  (bases 1 to 3202)
  AUTHORS   Brown,S.M., Wager-Miller,J. and Mackie,K.
  TITLE     Cloning and molecular characterization of the rat CB2 cannabinoid
            receptor
  JOURNAL   Biochim Biophys Acta 1576 (3), 255-264 (2002)
   PUBMED   12084572
  REMARK    GeneRIF: The rat peripheral cannabinoid receptor (rCB2) was cloned
            from a Sprague-Dawley rat spleen cDNA library and when translated,
            encodes a protein of 410 amino acids.
REFERENCE   8  (bases 1 to 3202)
  AUTHORS   Clayton,N., Marshall,F.H., Bountra,C. and O'Shaughnessy,C.T.
  TITLE     CB1 and CB2 cannabinoid receptors are implicated in inflammatory
            pain
  JOURNAL   Pain 96 (3), 253-260 (2002)
   PUBMED   11972997
  REMARK    GeneRIF: CB1 and CB2 cannabinoid receptors are implicated in
            inflammatory pain.
REFERENCE   9  (bases 1 to 3202)
  AUTHORS   Carlisle,S.J., Marciano-Cabral,F., Staab,A., Ludwick,C. and
            Cabral,G.A.
  TITLE     Differential expression of the CB2 cannabinoid receptor by rodent
            macrophages and macrophage-like cells in relation to cell
            activation
  JOURNAL   Int Immunopharmacol 2 (1), 69-82 (2002)
   PUBMED   11789671
  REMARK    GeneRIF: levels of the cannabinoid receptor type 2 in cells of
            macrophage lineage undergo major modulatory changes in relation to
            cell activation
REFERENCE   10 (bases 1 to 3202)
  AUTHORS   Griffin,G., Tao,Q. and Abood,M.E.
  TITLE     Cloning and pharmacological characterization of the rat CB(2)
            cannabinoid receptor
  JOURNAL   J Pharmacol Exp Ther 292 (3), 886-894 (2000)
   PUBMED   10688601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 25, 2024 this sequence version replaced NM_001164142.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.8170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000005.1  153427028-153427149
            123-3202            JAXUCZ010000005.1  153432013-153435092
FEATURES             Location/Qualifiers
     source          1..3202
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3202
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
     exon            1..122
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="upstream in-frame stop codon"
     exon            123..3202
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1255
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     peripheral cannabinoid receptor; CB2 receptor; cannabinoid
                     receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2 isoform 1"
                     /protein_id="NP_001157614.1"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
                     /translation="MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMG
                     LLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDS
                     RNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQ
                     HVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDK
                     VKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPK
                     SSVTETEAEVKTTTGPGSRTPGCSNC"
     misc_feature    203..205
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); glycosylation site"
     misc_feature    272..1102
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    272..1102
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    272..349
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    275..355
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    275..355
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    377..454
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    377..454
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    386..448
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    order(440..442,497..502,509..514,521..523,752..754,
                     944..946,965..967,1016..1018,1025..1027)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    order(440..442,497..502,509..514,521..523,752..754,
                     944..946,965..967,1016..1018,1025..1027)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    485..559
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    488..580
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    488..580
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    614..676
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    614..676
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    620..688
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    728..817
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    728..817
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    737..814
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    884..976
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    884..976
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    911..973
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1004..1081
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1004..1081
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1010..1075
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1151..1252
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1175..1177
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1178..1180
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1184..1186
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1226..1228
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P34972; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
ORIGIN      
        1 atttcctttc ctactcactc tggacaggaa cagctgtctg cagccacgcc gcgcctgagt
       61 gaggagaggc gtaggcacca gccgaggcca cccagcaaac atctatgctg actctgaatg
      121 ggcccagtcc tccggaacag ctccggtaga agcagccaaa gcctgtctgt ccatggcggg
      181 atgccgggag ctggagttga ccaacggctc caatggcggc ttggagttca accctatgaa
      241 ggagtacatg atcttgagtg atgcgcagca gatcgctgtg gcggtgctgt gtaccctgat
      301 ggggctgctg agtgccctgg agaacgtggc tgtgctctat ctcatcctgt cctcgcagcg
      361 gctccgcagg aagccctcgt acctgttcat cggcagcttg gccggagctg acttcctggc
      421 cagcgtgatc tttgcctgca acttcgtcat cttccatgtc tttcacggtg tggactccag
      481 gaatatcttc ctgttgaaga tcggcagcgt gaccatgacc ttcacggcct ctgtgggcag
      541 cctgctgctg accgctgttg accgatacct atgtctgtgc tacccaccta cctacaaagc
      601 tctcgtcacc cgtgggaggg cactggtggc ccttggtgtc atgtgggtcc tctcggcgtt
      661 gatctcctac ctaccgctca tggggtggac ttgttgtcct agtccctgtt ctgaactttt
      721 ccccctgatc cccaacgact acctcctggg ctggcttctt ttcattgcca tcctcttttc
      781 tggcatcatc tatacctatg ggtatgtcct ctggaaagca caccaacatg tagccagctt
      841 ggctgagcac caggacaggc aggtgcctgg gatagctcgg atgcggctag acgtgaggtt
      901 ggccaagact ctgggcctgg tcatggctgt tctgctcata tgctggttcc ctgcactggc
      961 tctcatgggc catagcctgg tcaccacact gagtgacaag gtcaaggagg ccttcgcctt
     1021 ctgctccatg ctgtgccttg ttaactccat gatcaatcct atcatttatg ccctgcggag
     1081 tggagagatc cgctctgctg cccagcactg cctgacaggc tggaagaaat atctccaggg
     1141 cctcggatct gaggggaaag aagaagcccc aaagtcctca gttacagaga cagaggctga
     1201 ggtgaaaacc accacagggc cgggatccag aacaccaggc tgctccaatt gctgatacgg
     1261 cctgtctttc tttctttctt tttttttttt ttttaaagat ttatttattt attatatata
     1321 agtacactgt agctgtcttc agatacacca gaagagggca tcagatctct ttacagatgg
     1381 ttgtgagcca ccatgtggtt gctgggattt gaactcagga cctctggaaa agcagtcggg
     1441 tgctcttaac cactgagcca tctctccagc ccacggcctg tctttctatg gaagcagtcc
     1501 gactcagaag tcaggtcact ccctccagaa gagaggggtc ctggaccctg aatatttctg
     1561 aagccagctc tagggtaatg gaaacagaac ttcccacccc cttttttgct aaggagtgct
     1621 ggggttcatg gctggaagac ggcctggtct tgcctacctt acgcagtctg tggagagggg
     1681 cctgtaaaaa tggcgggctc tgttcacatc aaatcgggaa accctcctga ctccagagac
     1741 ctagaggcca gaggggcctc cagggacgat aatgaaggac tcaggggatc tgtgaagaca
     1801 agggacctgt tctcctggaa tctaggctac cccggctgtg aggcctctgc ccacaacttc
     1861 acagatgtcc atatcttcca cagtgtgggt tctaggccgc cctgctgaag atggatagca
     1921 agaccagcta tttctggttc ctgcttcact gattggaact ctgtggctgt agagcgatgt
     1981 gaccttcagg ccacccttgc ctcttgagga tcaagaatta tgatgtgctg aggaccaagg
     2041 aggttcactc tctcccttca gacagagcca tgtgctgtca gctcagggta tcttgttgtt
     2101 ggaacaggac cctcctgata gcccgataag ccttgaaaat cattatgact ttaggtcctt
     2161 ggggacccac gggaagccag gttcacttga ggtacagagt cctcagagaa ctgtatggac
     2221 cttgtgacct tctgctgtgt ctcccatagc actatcccag tccagcctag cttcagtaaa
     2281 aatcaaggta ttcacaaaga gtctttgggt tctagattgt tcctagtgat gctcaactca
     2341 gcttcccttg cctcttccag actctggtcc tgaaggataa gcaggagttg ggaggagact
     2401 gcctgctgcg gacatcctcg atccacagcc ccatgctgtc tctgggtacc tgcattttac
     2461 cttcagcaaa ggttgcattc ccaacagacg gaggttcaag gcgctgctgg tggtaggggt
     2521 aggtagcact ggggaccgaa gacacggtga aaggaaaacc ctcaaacact ttctactttt
     2581 gcttttagca gattcagcca acagacaaga cgtccgtccc cattgcccag aggaactaac
     2641 atggtggtgt tcagtgagaa gaccaatcag cctccctaat aaagcagggc agtccactct
     2701 gctataaacc ctctcacatg cctctgcagg aggacatttt gttttctctg ttaaggtcaa
     2761 gtgaaggtca cagtgtctca ttttattctt cccaagacaa gttctgtgca tcaaaagctg
     2821 ctgcaaattc tactctaatc gctatgtggg aggactcggg gaagaagttg attcgtctgg
     2881 gctttgtgtt ttagaccgta tttcaacata cacttgggaa ggaagaaaca gaaaatacat
     2941 tgtgtttcct tgttactccc caaaggagga agtgcttggt tctgtcaact tcaacagatt
     3001 tctccaaggt gccagacaga gaaggtggag atacggtttc cgcagctgtg aattccggca
     3061 ccacctttgg ccctcacttg cttgtgtgat cttgggcaac ccctgccctt tgccttgctt
     3121 tggtttcctc cttggtacat cgggaatggt aggaaagaag atgccttcaa ggggcattca
     3181 ttaaaacctg gtattgctct aa
//
LOCUS       NM_001164143            3300 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant
            1, mRNA.
ACCESSION   NM_001164143
VERSION     NM_001164143.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Smereczanska,M., Domian,N., Lewandowska,A. and Kasacka,I.
  TITLE     Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid
            receptors in the adrenals of hypertensive rats
  JOURNAL   J Cell Mol Med 28 (10), e18376 (2024)
   PUBMED   38780511
  REMARK    GeneRIF: Comparative assessment of CacyBP/SIP, beta-catenin and
            cannabinoid receptors in the adrenals of hypertensive rats.
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   3  (bases 1 to 3300)
  AUTHORS   Kang,H., Jiang,S., Song,Q. and Zhang,Y.
  TITLE     [Activation of cannabinoid receptor 2 alleviates acute lung injury
            in rats with lipopolysaccharide-induced sepsis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1374-1380 (2022)
   PUBMED   36210711
  REMARK    GeneRIF: [Activation of cannabinoid receptor 2 alleviates acute
            lung injury in rats with lipopolysaccharide-induced sepsis].
REFERENCE   4  (bases 1 to 3300)
  AUTHORS   Karan,A.A., Spivak,Y.S., Gerasimov,K.A., Suleymanova,E.M.,
            Volobueva,M.N., Kvichansky,A.A., Vinogradova,L.V. and
            Bolshakov,A.P.
  TITLE     CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex
  JOURNAL   Mol Neurobiol 58 (8), 4028-4037 (2021)
   PUBMED   33907944
  REMARK    GeneRIF: CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex.
REFERENCE   5  (bases 1 to 3300)
  AUTHORS   Gigante,I., Tutino,V., Russo,F., De Nunzio,V., Coletta,S.,
            Armentano,R., Crovace,A., Caruso,M.G., Orlando,A. and
            Notarnicola,M.
  TITLE     Cannabinoid Receptors Overexpression in a Rat Model of Irritable
            Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
  JOURNAL   Int J Mol Sci 22 (6), 2880 (2021)
   PUBMED   33809047
  REMARK    GeneRIF: Cannabinoid Receptors Overexpression in a Rat Model of
            Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic
            Diet.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3300)
  AUTHORS   Esposito,G., Ligresti,A., Izzo,A.A., Bisogno,T., Ruvo,M., Di
            Rosa,M., Di Marzo,V. and Iuvone,T.
  TITLE     The endocannabinoid system protects rat glioma cells against HIV-1
            Tat protein-induced cytotoxicity. Mechanism and regulation
  JOURNAL   J Biol Chem 277 (52), 50348-50354 (2002)
   PUBMED   12388547
  REMARK    GeneRIF: protects rat glioma cells against HIV-1 Tat
            protein-induced cytotoxicity
REFERENCE   7  (bases 1 to 3300)
  AUTHORS   Brown,S.M., Wager-Miller,J. and Mackie,K.
  TITLE     Cloning and molecular characterization of the rat CB2 cannabinoid
            receptor
  JOURNAL   Biochim Biophys Acta 1576 (3), 255-264 (2002)
   PUBMED   12084572
  REMARK    GeneRIF: The rat peripheral cannabinoid receptor (rCB2) was cloned
            from a Sprague-Dawley rat spleen cDNA library and when translated,
            encodes a protein of 410 amino acids.
REFERENCE   8  (bases 1 to 3300)
  AUTHORS   Clayton,N., Marshall,F.H., Bountra,C. and O'Shaughnessy,C.T.
  TITLE     CB1 and CB2 cannabinoid receptors are implicated in inflammatory
            pain
  JOURNAL   Pain 96 (3), 253-260 (2002)
   PUBMED   11972997
  REMARK    GeneRIF: CB1 and CB2 cannabinoid receptors are implicated in
            inflammatory pain.
REFERENCE   9  (bases 1 to 3300)
  AUTHORS   Carlisle,S.J., Marciano-Cabral,F., Staab,A., Ludwick,C. and
            Cabral,G.A.
  TITLE     Differential expression of the CB2 cannabinoid receptor by rodent
            macrophages and macrophage-like cells in relation to cell
            activation
  JOURNAL   Int Immunopharmacol 2 (1), 69-82 (2002)
   PUBMED   11789671
  REMARK    GeneRIF: levels of the cannabinoid receptor type 2 in cells of
            macrophage lineage undergo major modulatory changes in relation to
            cell activation
REFERENCE   10 (bases 1 to 3300)
  AUTHORS   Griffin,G., Tao,Q. and Abood,M.E.
  TITLE     Cloning and pharmacological characterization of the rat CB(2)
            cannabinoid receptor
  JOURNAL   J Pharmacol Exp Ther 292 (3), 886-894 (2000)
   PUBMED   10688601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Oct 7, 2014 this sequence version replaced NM_001164143.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000005.1  153409184-153409403
            221-3300            JAXUCZ010000005.1  153432013-153435092
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3300
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
     exon            1..220
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="upstream in-frame stop codon"
     exon            221..3300
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1353
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peripheral cannabinoid receptor; CB2 receptor; cannabinoid
                     receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2 isoform 1"
                     /protein_id="NP_001157615.1"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
                     /translation="MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMG
                     LLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDS
                     RNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQ
                     HVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDK
                     VKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPK
                     SSVTETEAEVKTTTGPGSRTPGCSNC"
     misc_feature    301..303
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); glycosylation site"
     misc_feature    370..1200
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    370..1200
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    370..447
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    373..453
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    373..453
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    475..552
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    475..552
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    484..546
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    order(538..540,595..600,607..612,619..621,850..852,
                     1042..1044,1063..1065,1114..1116,1123..1125)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    order(538..540,595..600,607..612,619..621,850..852,
                     1042..1044,1063..1065,1114..1116,1123..1125)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    583..657
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    586..678
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    586..678
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    712..774
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    712..774
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    718..786
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    826..915
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    826..915
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    835..912
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    982..1074
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    982..1074
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    1009..1071
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1102..1179
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1102..1179
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    1108..1173
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1249..1350
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1273..1275
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1276..1278
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1282..1284
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1324..1326
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P34972; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
ORIGIN      
        1 gacactgggg actcagaggg gaagtggtaa cagggacaga cggaaggcca gacctcctct
       61 cacccactca tctacaaaag tgtaaaagca agaaaaacca ggctggggct gcagctccct
      121 ggacctacgt ggtggtcctg tccaggtctc cagatctaaa tacaaaatag ccaggacaag
      181 gcttcacaag accctggagg ccagcggctg acaaatgact cccagtcctc cggaacagct
      241 ccggtagaag cagccaaagc ctgtctgtcc atggcgggat gccgggagct ggagttgacc
      301 aacggctcca atggcggctt ggagttcaac cctatgaagg agtacatgat cttgagtgat
      361 gcgcagcaga tcgctgtggc ggtgctgtgt accctgatgg ggctgctgag tgccctggag
      421 aacgtggctg tgctctatct catcctgtcc tcgcagcggc tccgcaggaa gccctcgtac
      481 ctgttcatcg gcagcttggc cggagctgac ttcctggcca gcgtgatctt tgcctgcaac
      541 ttcgtcatct tccatgtctt tcacggtgtg gactccagga atatcttcct gttgaagatc
      601 ggcagcgtga ccatgacctt cacggcctct gtgggcagcc tgctgctgac cgctgttgac
      661 cgatacctat gtctgtgcta cccacctacc tacaaagctc tcgtcacccg tgggagggca
      721 ctggtggccc ttggtgtcat gtgggtcctc tcggcgttga tctcctacct accgctcatg
      781 gggtggactt gttgtcctag tccctgttct gaacttttcc ccctgatccc caacgactac
      841 ctcctgggct ggcttctttt cattgccatc ctcttttctg gcatcatcta tacctatggg
      901 tatgtcctct ggaaagcaca ccaacatgta gccagcttgg ctgagcacca ggacaggcag
      961 gtgcctggga tagctcggat gcggctagac gtgaggttgg ccaagactct gggcctggtc
     1021 atggctgttc tgctcatatg ctggttccct gcactggctc tcatgggcca tagcctggtc
     1081 accacactga gtgacaaggt caaggaggcc ttcgccttct gctccatgct gtgccttgtt
     1141 aactccatga tcaatcctat catttatgcc ctgcggagtg gagagatccg ctctgctgcc
     1201 cagcactgcc tgacaggctg gaagaaatat ctccagggcc tcggatctga ggggaaagaa
     1261 gaagccccaa agtcctcagt tacagagaca gaggctgagg tgaaaaccac cacagggccg
     1321 ggatccagaa caccaggctg ctccaattgc tgatacggcc tgtctttctt tctttctttt
     1381 tttttttttt ttaaagattt atttatttat tatatataag tacactgtag ctgtcttcag
     1441 atacaccaga agagggcatc agatctcttt acagatggtt gtgagccacc atgtggttgc
     1501 tgggatttga actcaggacc tctggaaaag cagtcgggtg ctcttaacca ctgagccatc
     1561 tctccagccc acggcctgtc tttctatgga agcagtccga ctcagaagtc aggtcactcc
     1621 ctccagaaga gaggggtcct ggaccctgaa tatttctgaa gccagctcta gggtaatgga
     1681 aacagaactt cccaccccct tttttgctaa ggagtgctgg ggttcatggc tggaagacgg
     1741 cctggtcttg cctaccttac gcagtctgtg gagaggggcc tgtaaaaatg gcgggctctg
     1801 ttcacatcaa atcgggaaac cctcctgact ccagagacct agaggccaga ggggcctcca
     1861 gggacgataa tgaaggactc aggggatctg tgaagacaag ggacctgttc tcctggaatc
     1921 taggctaccc cggctgtgag gcctctgccc acaacttcac agatgtccat atcttccaca
     1981 gtgtgggttc taggccgccc tgctgaagat ggatagcaag accagctatt tctggttcct
     2041 gcttcactga ttggaactct gtggctgtag agcgatgtga ccttcaggcc acccttgcct
     2101 cttgaggatc aagaattatg atgtgctgag gaccaaggag gttcactctc tcccttcaga
     2161 cagagccatg tgctgtcagc tcagggtatc ttgttgttgg aacaggaccc tcctgatagc
     2221 ccgataagcc ttgaaaatca ttatgacttt aggtccttgg ggacccacgg gaagccaggt
     2281 tcacttgagg tacagagtcc tcagagaact gtatggacct tgtgaccttc tgctgtgtct
     2341 cccatagcac tatcccagtc cagcctagct tcagtaaaaa tcaaggtatt cacaaagagt
     2401 ctttgggttc tagattgttc ctagtgatgc tcaactcagc ttcccttgcc tcttccagac
     2461 tctggtcctg aaggataagc aggagttggg aggagactgc ctgctgcgga catcctcgat
     2521 ccacagcccc atgctgtctc tgggtacctg cattttacct tcagcaaagg ttgcattccc
     2581 aacagacgga ggttcaaggc gctgctggtg gtaggggtag gtagcactgg ggaccgaaga
     2641 cacggtgaaa ggaaaaccct caaacacttt ctacttttgc ttttagcaga ttcagccaac
     2701 agacaagacg tccgtcccca ttgcccagag gaactaacat ggtggtgttc agtgagaaga
     2761 ccaatcagcc tccctaataa agcagggcag tccactctgc tataaaccct ctcacatgcc
     2821 tctgcaggag gacattttgt tttctctgtt aaggtcaagt gaaggtcaca gtgtctcatt
     2881 ttattcttcc caagacaagt tctgtgcatc aaaagctgct gcaaattcta ctctaatcgc
     2941 tatgtgggag gactcgggga agaagttgat tcgtctgggc tttgtgtttt agaccgtatt
     3001 tcaacataca cttgggaagg aagaaacaga aaatacattg tgtttccttg ttactcccca
     3061 aaggaggaag tgcttggttc tgtcaacttc aacagatttc tccaaggtgc cagacagaga
     3121 aggtggagat acggtttccg cagctgtgaa ttccggcacc acctttggcc ctcacttgct
     3181 tgtgtgatct tgggcaaccc ctgccctttg ccttgctttg gtttcctcct tggtacatcg
     3241 ggaatggtag gaaagaagat gccttcaagg ggcattcatt aaaacctggt attgctctaa
//
LOCUS       NM_023970               3211 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 4 (Trpv4), mRNA.
ACCESSION   NM_023970
VERSION     NM_023970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3211)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   2  (bases 1 to 3211)
  AUTHORS   Bihari,S., Costell,M.H., Bouchier,T., Behm,D.J., Burgert,M., Ye,G.,
            Bersten,A.D., Puukila,S., Cavallaro,E., Sprecher,D.L. and
            Dixon,D.L.
  TITLE     Evaluation of GSK2789917-induced TRPV4 inhibition in animal models
            of fluid induced lung injury
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (5), 3461-3475 (2024)
   PUBMED   37966569
  REMARK    GeneRIF: Evaluation of GSK2789917-induced TRPV4 inhibition in
            animal models of fluid induced lung injury.
REFERENCE   3  (bases 1 to 3211)
  AUTHORS   Philip,N., Yun,X., Pi,H., Murray,S., Hill,Z., Fonticella,J.,
            Perez,P., Zhang,C., Pathmasiri,W., Sumner,S., Servinsky,L.,
            Jiang,H., Huetsch,J.C., Oldham,W.M., Visovatti,S., Leary,P.J.,
            Gharib,S.A., Brittain,E., Simpson,C.E., Le,A., Shimoda,L.A. and
            Suresh,K.
  TITLE     Fatty acid metabolism promotes TRPV4 activity in lung microvascular
            endothelial cells in pulmonary arterial hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (3), L252-L265 (2024)
   PUBMED   38226418
  REMARK    GeneRIF: Fatty acid metabolism promotes TRPV4 activity in lung
            microvascular endothelial cells in pulmonary arterial hypertension.
REFERENCE   4  (bases 1 to 3211)
  AUTHORS   Li,X., Lu,K., Guo,S., Xue,S. and Lian,F.
  TITLE     TRPV4 blockade alleviates endoplasmic reticulum stress mediated
            apoptosis in hypoxia-induced cardiomyocyte injury
  JOURNAL   Cell Signal 114, 110973 (2024)
   PUBMED   37981067
  REMARK    GeneRIF: TRPV4 blockade alleviates endoplasmic reticulum stress
            mediated apoptosis in hypoxia-induced cardiomyocyte injury.
REFERENCE   5  (bases 1 to 3211)
  AUTHORS   Shen,X., Zhang,H., Chen,D.T. and Cao,Y.L.
  TITLE     [Preliminary study of TRPV4 affects chondrocyte degeneration]
  JOURNAL   Zhongguo Gu Shang 36 (10), 990-995 (2023)
   PUBMED   37881934
  REMARK    GeneRIF: [Preliminary study of TRPV4 affects chondrocyte
            degeneration].
REFERENCE   6  (bases 1 to 3211)
  AUTHORS   Strotmann,R., Schultz,G. and Plant,T.D.
  TITLE     Ca2+-dependent potentiation of the nonselective cation channel
            TRPV4 is mediated by a C-terminal calmodulin binding site
  JOURNAL   J Biol Chem 278 (29), 26541-26549 (2003)
   PUBMED   12724311
REFERENCE   7  (bases 1 to 3211)
  AUTHORS   Mizuno,A., Matsumoto,N., Imai,M. and Suzuki,M.
  TITLE     Impaired osmotic sensation in mice lacking TRPV4
  JOURNAL   Am J Physiol Cell Physiol 285 (1), C96-C101 (2003)
   PUBMED   12777254
REFERENCE   8  (bases 1 to 3211)
  AUTHORS   Xu,H., Zhao,H., Tian,W., Yoshida,K., Roullet,J.B. and Cohen,D.M.
  TITLE     Regulation of a transient receptor potential (TRP) channel by
            tyrosine phosphorylation. SRC family kinase-dependent tyrosine
            phosphorylation of TRPV4 on TYR-253 mediates its response to
            hypotonic stress
  JOURNAL   J Biol Chem 278 (13), 11520-11527 (2003)
   PUBMED   12538589
REFERENCE   9  (bases 1 to 3211)
  AUTHORS   Liedtke,W., Choe,Y., Marti-Renom,M.A., Bell,A.M., Denis,C.S.,
            Sali,A., Hudspeth,A.J., Friedman,J.M. and Heller,S.
  TITLE     Vanilloid receptor-related osmotically activated channel (VR-OAC),
            a candidate vertebrate osmoreceptor
  JOURNAL   Cell 103 (3), 525-535 (2000)
   PUBMED   11081638
REFERENCE   10 (bases 1 to 3211)
  AUTHORS   Strotmann,R., Harteneck,C., Nunnenmacher,K., Schultz,G. and
            Plant,T.D.
  TITLE     OTRPC4, a nonselective cation channel that confers sensitivity to
            extracellular osmolarity
  JOURNAL   Nat Cell Biol 2 (10), 695-702 (2000)
   PUBMED   11025659
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF263521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF263521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3211
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 4"
                     /db_xref="GeneID:66026"
                     /db_xref="RGD:69337"
     exon            1..54
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            55..479
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2709
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="transient receptor potential cation channel,
                     subfamily 5, member 4; VR-OAC; osm-9-like TRP channel 4;
                     vanilloid receptor-related osmotically-activated channel;
                     osmosensitive transient receptor potential channel 4;
                     vanilloid receptor-related osmotically activated channel
                     (Vroac); transient receptor potential cation channel subf
                     V memb 4"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 4"
                     /protein_id="NP_076460.1"
                     /db_xref="GeneID:66026"
                     /db_xref="RGD:69337"
                     /translation="MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEE
                     GSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKA
                     PMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSR
                     GSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAE
                     RTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPK
                     DEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADN
                     TRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRR
                     EVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEML
                     AVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDY
                     LRLAGEVITLLTGVLFFFTSIKDLFMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAAL
                     YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF
                     MIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACRDSETFSAFLLDLFKLTIGMGD
                     LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT
                     ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINED
                     PGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDEVVVPLDNLGNPNCDGH
                     QQGYAPKWRAEDAPL"
     misc_feature    94..297
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    400..2595
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV), type 4; Region: TRPV4; cd22195"
                     /db_xref="CDD:411979"
     misc_feature    400..2595
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV), type 4; Region: TRPV4; cd22195"
                     /db_xref="CDD:411979"
     misc_feature    421..522
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    421..423
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPK8; propagated from
                     UniProtKB/Swiss-Prot (Q9ERZ8.1); phosphorylation site"
     misc_feature    664..786
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    664..786
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(802..804,808..810,820..825,832..840,844..849,
                     859..861,868..870,895..897,943..945,949..951,961..966,
                     973..981,985..990,1000..1002,1009..1011,1045..1047,
                     1051..1053,1057..1059,1069..1074,1081..1089,1120..1125,
                     1135..1137)
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    order(802..804,808..810,820..825,832..840,844..849,
                     859..861,868..870,895..897,943..945,949..951,961..966,
                     973..981,985..990,1000..1002,1009..1011,1045..1047,
                     1051..1053,1057..1059,1069..1074,1081..1089,1120..1125,
                     1135..1137)
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    802..897
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    802..897
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    802..891
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: ANK 1"
     misc_feature    order(832..834,838..840,907..912,934..939,943..945,
                     973..975,1084..1086,1105..1107,1114..1116,1318..1320,
                     1324..1335,1561..1563,1735..1737,1744..1749,1756..1758,
                     1810..1812,1816..1818,1822..1824,1828..1833,1840..1845,
                     1852..1854,1897..1902,1909..1911,1921..1923,1933..1935,
                     1951..1953,1963..1965,1975..1977,1984..1986,1993..1998,
                     2104..2106,2113..2118,2125..2127,2131..2133,2155..2157,
                     2167..2169,2173..2181,2185..2193,2206..2208,2212..2217,
                     2221..2229,2236..2238,2245..2250,2254..2262,2266..2268,
                     2446..2448,2455..2457)
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411979"
     misc_feature    order(832..834,838..840,907..912,934..939,943..945,
                     973..975,1084..1086,1105..1107,1114..1116,1318..1320,
                     1324..1335,1561..1563,1735..1737,1744..1749,1756..1758,
                     1810..1812,1816..1818,1822..1824,1828..1833,1840..1845,
                     1852..1854,1897..1902,1909..1911,1921..1923,1933..1935,
                     1951..1953,1963..1965,1975..1977,1984..1986,1993..1998,
                     2104..2106,2113..2118,2125..2127,2131..2133,2155..2157,
                     2167..2169,2173..2181,2185..2193,2206..2208,2212..2217,
                     2221..2229,2236..2238,2245..2250,2254..2262,2266..2268,
                     2446..2448,2455..2457)
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411979"
     misc_feature    850..852
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPK8; propagated from
                     UniProtKB/Swiss-Prot (Q9ERZ8.1); phosphorylation site"
     misc_feature    943..1047
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    943..1047
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    943..1032
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: ANK 2"
     misc_feature    1198..1287
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: ANK 3"
     misc_feature    1501..1563
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    1615..1695
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    1735..1797
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    1810..1872
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    1918..2001
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    2128..2139
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:O35433"
     misc_feature    2173..2259
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     transmembrane region"
     misc_feature    2506..2508
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPK8; propagated from
                     UniProtKB/Swiss-Prot (Q9ERZ8.1); phosphorylation site"
     misc_feature    2527..2586
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERZ8.1);
                     Region: Interaction with calmodulin and ITPR3.
                     /evidence=ECO:0000250|UniProtKB:Q9HBA0"
     misc_feature    2563..2565
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPK8; propagated from
                     UniProtKB/Swiss-Prot (Q9ERZ8.1); phosphorylation site"
     exon            480..652
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            653..805
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            806..946
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1245
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1425
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1584
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1677
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1751
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1917
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1984
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2301
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2429
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2551
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..3211
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggagga cgcggcggga tcaggaagcg gctgcgctgc gcccgcgtcc caagcaggcc
       61 gagaagtcca aacagatctg ctcagggtcc agtatggcag atcctggtga tggcccccgt
      121 gcagcgcctg gggatgtggc tgagccccct ggagacgaga gtggcacttc tggtggggag
      181 gccttccccc tctcttccct ggccaacctg tttgagggag aggaaggctc ctcttctctt
      241 tcaccagtgg atgctagccg ccctgctggc cccggggatg gacgtccaaa cctgcgtatg
      301 aagttccagg gcgctttccg caagggggtt cccaacccca ttgacctgct ggagtccacc
      361 ctgtatgagt cctcagtagt gcctgggccc aagaaagcgc ccatggattc gttgttcgac
      421 tatggcactt accggcacca ccccagtgac aacaagagat ggaggaggaa ggtcgtagag
      481 aagcagccac agagccccaa agctcccgcc ccccagccac cccccatcct caaagtcttc
      541 aaccggccca tcctctttga catcgtgtcc cggggctcca ctgccgacct ggacggactg
      601 ctctcctact tgctgaccca caagaagcgc ctgactgatg aggagttccg ggaaccatcc
      661 acagggaaga cctgcctgcc caaggcactt ctgaacttaa gcaatggccg aaacgacacc
      721 atcccagtgt tgctggacat tgcggaacgc acgggcaaca tgcgggagtt catcaactcg
      781 cccttcagag acatctacta ccgagggcag acggcactgc acatcgccat tgaacggcgc
      841 tgcaagcatt acgtggagct cctggtggcc cagggagccg atgtgcacgc gcaggcccga
      901 gggcggttct tccagcccaa ggatgagggt ggctacttct actttgggga gctgcccttg
      961 tccttggcag cctgcaccaa ccagccgcac atcgtcaact acctgacaga gaaccctcac
     1021 aagaaagccg atatgaggcg acaggactcc agaggcaaca cggtgctcca cgcgctggtg
     1081 gccatcgctg acaacacccg agagaacacc aagtttgtca ccaagatgta tgacctgttg
     1141 cttctcaagt gctcccgcct cttcccagac agcaacctgg agactgtgct taacaatgac
     1201 ggtctttcgc ccctcatgat ggctgccaag actggcaaga tcggggtctt tcagcacatc
     1261 atccgacggg aggtgacaga tgaggacaca cggcacctgt ctcgcaagtt caaggactgg
     1321 gcctacgggc ctgtgtattc ttctctctac gacctctcct ccctggatac gtgcggggag
     1381 gaagtgtccg tgctggagat cctggtttac aacagcaaga tcgagaaccg ccatgagatg
     1441 ctggctgtgg agcccattaa cgaactgctg agggacaagt ggcgtaagtt cggggccgtg
     1501 tccttctaca tcaacgttgt ctcctatctg tgtgccatgg tcatcttcac cctcacagcc
     1561 tactatcagc cactggaggg cacgccaccc tacccttacc gtaccacggt ggactacctg
     1621 aggctggctg gtgaggtcat cacgctcctc acaggagtcc tgttcttctt taccagtatc
     1681 aaagacttgt tcatgaagaa atgccctgga gtgaattctc tcttcgtcga tggctccttc
     1741 cagttgctct acttcatcta ctcagtgctg gtggttgtgt ctgcggcgct ctacctggca
     1801 gggatcgagg cctatctggc tgtgatggtc tttgccctgg tcctgggctg gatgaatgcc
     1861 ctttacttca cccgtgggct gaagctgaca gggacctaca gcatcatgat tcagaagatc
     1921 ctcttcaaag atctcttccg ctttctgctg gtctacctgc tttttatgat tggctatgcc
     1981 tcagctctgg tcaccctcct gaatccgtgc accaacatga aggtctgtaa cgaggaccag
     2041 agcaactgca cggtgccctc ataccccgcg tgccgggaca gcgagacctt cagcgccttc
     2101 ctactggacc tcttcaagct caccatcggc atgggcgacc tggagatgct gagcagcgct
     2161 aagtaccccg tggtcttcat tctcctgctg gttacctaca tcatcctcac cttcgtgctc
     2221 ctgctgaaca tgctcatcgc cctcatgggt gagaccgtgg gccaggtgtc caaggagagc
     2281 aagcacatct ggaagctgca gtgggccacc accatcctgg acatcgagcg ctccttccct
     2341 gtgttcctga ggaaggcctt ccgctccgga gagatggtga cagtgggcaa gagctcggat
     2401 ggcactccag accgcaggtg gtgcttcagg gtggacgagg tgaactggtc tcactggaac
     2461 cagaacctgg gcatcattaa cgaggacccc ggcaagagcg agatctacca gtactatggc
     2521 ttctcccata ccatggggcg cctccgcagg gatcgctggt cctcagtggt gccccgcgtg
     2581 gtggagctga acaagaactc aggcacagat gaagtggtgg tccccctgga taacctaggg
     2641 aaccccaact gtgacggcca ccagcaaggt tatgctccca agtggagggc ggaggacgca
     2701 ccactgtagg ggccatgcca gggctggggt caatggccca ggcttggccc ttgctcccac
     2761 ctacatttca gcatctgtcc tgtgtcttcc cacacccaca cgtgacctcg gaggtgaggg
     2821 cctctgtgga gactctgggg aggccccagg accctctggt ccccacaaag acttttgctc
     2881 ttatttctac tcctccccac atgggggacg gggctcctgg ccacctgtct cactcccatg
     2941 gagtcaccta agccagctca gggcccctcc actcacaggg ctcaggcccc tgtccctctt
     3001 gtgcactatt tattgctctc ctcaggaaaa tgacatcaca ggagtctacc tgcagctgga
     3061 acctggccag ggctgaggct catgcaggga cactgcagcc ctgacccgct gcagatctga
     3121 cctgctgcag cccgggctag ggtgggtctt ctgtactttg tagagatcgg ggctgttggt
     3181 gctcaataaa tgtttgttta ttctcggtgg a
//
LOCUS       NM_001107832            2044 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus prostaglandin E synthase 2 (Ptges2), mRNA.
ACCESSION   NM_001107832 XM_001078154 XM_231144
VERSION     NM_001107832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Shah,M.D., Gnanaraj,C., Khan,M.S. and Iqbal,M.
  TITLE     Dillenia suffruticosa L. Impedes Carbon Tetrachloride-Induced
            Hepatic Damage by Modulating Oxidative Stress and Inflammatory
            Markers in Rats
  JOURNAL   J Environ Pathol Toxicol Oncol 34 (2), 133-152 (2015)
   PUBMED   26081032
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Majed,B.H. and Khalil,R.A.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Hirata,T. and Narumiya,S.
  TITLE     Prostanoids as regulators of innate and adaptive immunity
  JOURNAL   Adv Immunol 116, 143-174 (2012)
   PUBMED   23063076
  REMARK    Review article
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Jiang,H., Deng,C.S., Zhang,M. and Xia,J.
  TITLE     Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic
            colitis by inhibiting expression of cyclooxygenase-2
  JOURNAL   World J Gastroenterol 12 (24), 3848-3853 (2006)
   PUBMED   16804969
  REMARK    GeneRIF: Curcumin has therapeutic effects on TNBS acid-induced
            colitis, the mechanisms seem to be related to COX-2 inhibition and
            PGE(2) improvement.
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Leppilampi,M., Parkkila,S., Karttunen,T., Gut,M.O., Gros,G. and
            Sjoblom,M.
  TITLE     Carbonic anhydrase isozyme-II-deficient mice lack the duodenal
            bicarbonate secretory response to prostaglandin E2
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15247-15252 (2005)
   PUBMED   16217040
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Giannico,G., Mendez,M. and LaPointe,M.C.
  TITLE     Regulation of the membrane-localized prostaglandin E synthases
            mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts
  JOURNAL   Am J Physiol Heart Circ Physiol 288 (1), H165-H174 (2005)
   PUBMED   15358613
  REMARK    GeneRIF: Prostaglandin E synthase(PGES)-1 and -2 are colocalized
            with COX-2 in cardiac myocytes and fibroblasts.
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Watanabe,K., Ohkubo,H., Niwa,H., Tanikawa,N., Koda,N., Ito,S. and
            Ohmiya,Y.
  TITLE     Essential 110Cys in active site of membrane-associated
            prostaglandin E synthase-2
  JOURNAL   Biochem Biophys Res Commun 306 (2), 577-581 (2003)
   PUBMED   12804604
REFERENCE   9  (bases 1 to 2044)
  AUTHORS   Hu,J., Meng,Q., Roy,S.K., Raha,A., Hu,J., Zhang,J., Hashimoto,K.
            and Kalvakolanu,D.V.
  TITLE     A novel transactivating factor that regulates
            interferon-gamma-dependent gene expression
  JOURNAL   J Biol Chem 277 (33), 30253-30263 (2002)
   PUBMED   12050152
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001078154.1, XM_231144.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231959.1, SRR8487226.130213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2044
                     /gene="Ptges2"
                     /note="prostaglandin E synthase 2"
                     /db_xref="GeneID:311865"
                     /db_xref="RGD:1310836"
     exon            1..787
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    473..475
                     /gene="Ptges2"
                     /note="upstream in-frame stop codon"
     CDS             512..1666
                     /gene="Ptges2"
                     /EC_number="5.3.99.3"
                     /codon_start=1
                     /product="prostaglandin E synthase 2"
                     /protein_id="NP_001101302.1"
                     /db_xref="GeneID:311865"
                     /db_xref="RGD:1310836"
                     /translation="MAQAARVAWVLGSSRCALSEGLLTRPWTQLSAQSRAGFTRAAAG
                     NRGASIRKGSPRLLGVAALALGGALGLYHTVRWHLRSQDLHAERSAVQLSLSNRLQLT
                     LYQYKTCPFCSKVRAFLDFHSLPYQVVEVNPVRRTEIKFSSYRKVPILVAQEGDSLQQ
                     LNDSSVIISALKTYLVSGQPLEEIITYYPPMKAMNDQGKEVTEFGNKYWLMLDQKEAQ
                     QMYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPAEALASFDYIVREGKFGAVEATM
                     AKYVGAAAMYFISKRLKSRHHLQDDVRVDLYEAANKWVTAVGKDRPFMGGQKPNLADL
                     AVYGVLRVMEGLEAFDDLMRHSHIQPWYLRMERAIKEASSMHCMHPNCKD"
     misc_feature    809..1039
                     /gene="Ptges2"
                     /note="GST_N family; microsomal Prostaglandin E synthase
                     Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored
                     dimeric protein containing a CXXC motif which catalyzes
                     the isomerization of PGH2 to PGE2. Unlike cytosolic PGE
                     synthase (cPGES) and microsomal...; Region: GST_N_mPGES2;
                     cd03040"
                     /db_xref="CDD:239338"
     misc_feature    809..1039
                     /gene="Ptges2"
                     /note="GST_N family; microsomal Prostaglandin E synthase
                     Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored
                     dimeric protein containing a CXXC motif which catalyzes
                     the isomerization of PGH2 to PGE2. Unlike cytosolic PGE
                     synthase (cPGES) and microsomal...; Region: GST_N_mPGES2;
                     cd03040"
                     /db_xref="CDD:239338"
     misc_feature    order(827..829,833..847)
                     /gene="Ptges2"
                     /note="GRX-like active site [active]"
                     /db_xref="CDD:239338"
     misc_feature    order(827..829,833..847)
                     /gene="Ptges2"
                     /note="GRX-like active site [active]"
                     /db_xref="CDD:239338"
     misc_feature    order(830..838,848..853,857..862,872..874,905..913,
                     923..925,1004..1006,1016..1018)
                     /gene="Ptges2"
                     /note="C-terminal domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239338"
     misc_feature    order(830..838,848..853,857..862,872..874,905..913,
                     923..925,1004..1006,1016..1018)
                     /gene="Ptges2"
                     /note="C-terminal domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239338"
     misc_feature    order(947..949,995..1000,1004..1009,1016..1018)
                     /gene="Ptges2"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239338"
     misc_feature    order(947..949,995..1000,1004..1009,1016..1018)
                     /gene="Ptges2"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239338"
     misc_feature    1178..1624
                     /gene="Ptges2"
                     /note="C-terminal, alpha helical domain of microsomal
                     Prostaglandin E synthase Type 2; Region: GST_C_mPGES2;
                     cd03197"
                     /db_xref="CDD:198306"
     misc_feature    1178..1624
                     /gene="Ptges2"
                     /note="C-terminal, alpha helical domain of microsomal
                     Prostaglandin E synthase Type 2; Region: GST_C_mPGES2;
                     cd03197"
                     /db_xref="CDD:198306"
     misc_feature    order(1181..1183,1193..1195,1214..1216,1229..1231,
                     1394..1396,1400..1402)
                     /gene="Ptges2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:198306"
     misc_feature    order(1181..1183,1193..1195,1214..1216,1229..1231,
                     1394..1396,1400..1402)
                     /gene="Ptges2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:198306"
     misc_feature    order(1211..1213,1223..1225,1295..1300,1307..1309,
                     1496..1498,1523..1525,1532..1537)
                     /gene="Ptges2"
                     /note="N-terminal domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:198306"
     misc_feature    order(1211..1213,1223..1225,1295..1300,1307..1309,
                     1496..1498,1523..1525,1532..1537)
                     /gene="Ptges2"
                     /note="N-terminal domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:198306"
     misc_feature    order(1244..1249,1256..1261,1286..1288,1295..1300,
                     1535..1537,1547..1549)
                     /gene="Ptges2"
                     /note="GRX-like active site [active]"
                     /db_xref="CDD:198306"
     misc_feature    order(1244..1249,1256..1261,1286..1288,1295..1300,
                     1535..1537,1547..1549)
                     /gene="Ptges2"
                     /note="GRX-like active site [active]"
                     /db_xref="CDD:198306"
     exon            788..985
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1044
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1194
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1395
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1513
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2044
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttgaggc ctttgggttg gcgatccggc ccccttagct tgaaccattt ccgaagcacg
       61 tggttttcaa ggcccccgct gggtttgaga aaagtttatg gttcgcgtca caacagcagc
      121 gtacagcatt gcgggagggc agaaggcgtc taagacgctg cggccgccta ttggagacag
      181 cgttggactt tttctgggta gtgcatgggt cggaagactg gcgttttccc tgacatcgta
      241 gattcacgat gtggaaacgc ccgaccacga gtcacaggtt accgttgcac ccctagaagg
      301 cagcgacatc aagccacttc caaagcccct ggggtgtagt tctgcctctc aggcagacaa
      361 gcgctcccgt tcccttcacg gcctctagtc ctacttggcg tcatcgttac cctaggcaac
      421 acacagacac agagtgctgt ccctttaagg aatcctagca ccttggccat tttagttttg
      481 cgcgcccgcc cgcagcaccg gcaaagcgaa catggcccag gcagcgcgcg ttgcgtgggt
      541 gcttggctct agccggtgcg ccctgtcaga ggggctgctc acacgaccct ggacacaact
      601 ctcggcacag agccgggcgg gcttcaccag ggcggcagcg ggaaaccggg gcgcctcgat
      661 ccgcaagggg agcccgcggt tgctgggggt ggcggcgctg gccctgggcg gcgctctggg
      721 gctgtaccac actgtgcggt ggcacctgcg ctcccaggac ctccacgccg agcgctcggc
      781 tgtgcagctg tccctgtcca accgcctgca gctgaccctg taccagtaca agacatgtcc
      841 cttctgcagc aaagtccgtg ccttcctcga cttccactcc ctgccctatc aggtggtaga
      901 ggtgaatccc gtgagaagga ccgagattaa attctcctcc tacaggaagg tacccatcct
      961 ggtggcccag gaaggagaca gcttgcaaca gctcaatgac tcctcagtca tcattagtgc
     1021 cctcaagacc tacctggttt cagggcagcc cctggaagag atcatcactt attacccacc
     1081 catgaaggcc atgaatgatc agggcaagga ggtaaccgag ttcggcaaca agtactggct
     1141 catgctggac cagaaggagg cccagcagat gtatggcgga aaggaagcca ggacggagga
     1201 gatgaagtgg cggcagtggg cggatgactg gctggtgcat ctcatctctc ccaacgtgta
     1261 ccgaacacct gccgaggccc tggcttcctt cgactatatt gtccgtgagg gcaagtttgg
     1321 ggctgtggag gccaccatgg ccaagtacgt gggcgcagct gccatgtact tcatcagcaa
     1381 gcgcctcaaa agcaggcacc acctgcagga tgatgtccgg gtagacctct atgaagcagc
     1441 caacaagtgg gtgacagccg tgggcaaaga ccggccattc atggggggtc agaagcctaa
     1501 ccttgctgac ctggcagtgt atggtgtgct gcgagtgatg gagggtctgg aagcctttga
     1561 cgacctgatg cgacactcac acatccagcc ttggtacctg cggatggagc gggccatcaa
     1621 agaagcctct tcaatgcact gtatgcaccc taattgcaaa gactagctgc tagaggcacg
     1681 agacctggac cagtccctgg ctgtgcttgt agggcagtca tttcatctct agcctccagt
     1741 tctctatttc taatactgga catttctagg gcccttgacg ctgaggacaa ggcccaaact
     1801 taatagctgt tctgaggata aagggtctgg gggtcacaaa ggactaccct ccaatcccag
     1861 ttccagagcc tgatctccca acggggactc ctttcaactc ctctagggct cagtcccttg
     1921 ttgactcgga tcaggcaatc tgttaacaaa agccctgtcc acgtgcctcg gagttccagc
     1981 tcttcccgtg cccctgggac tgttgtattt gtaataaagg agaggtctgc tgctcccctc
     2041 tggc
//
LOCUS       NM_013032               1821 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 1 member 1 (Slc1a1), mRNA.
ACCESSION   NM_013032 XM_346583
VERSION     NM_013032.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Wang,J., Zielewicz,L., Dong,Y. and Grewer,C.
  TITLE     Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate
            Transporter EAAC1 with an Immobilized Transport Domain
  JOURNAL   Neurochem Res 47 (1), 148-162 (2022)
   PUBMED   33550531
  REMARK    GeneRIF: Pre-Steady-State Kinetics and Reverse Transport in Rat
            Glutamate Transporter EAAC1 with an Immobilized Transport Domain.
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Magi,S., Piccirillo,S., Maiolino,M., Lariccia,V. and Amoroso,S.
  TITLE     NCX1 and EAAC1 transporters are involved in the protective action
            of glutamate in an in vitro Alzheimer's disease-like model
  JOURNAL   Cell Calcium 91, 102268 (2020)
   PUBMED   32827867
  REMARK    GeneRIF: NCX1 and EAAC1 transporters are involved in the protective
            action of glutamate in an in vitro Alzheimer's disease-like model.
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Malik,A.R., Szydlowska,K., Nizinska,K., Asaro,A., van Vliet,E.A.,
            Popp,O., Dittmar,G., Fritsche-Guenther,R., Kirwan,J.A., Nykjaer,A.,
            Lukasiuk,K., Aronica,E. and Willnow,T.E.
  TITLE     SorCS2 Controls Functional Expression of Amino Acid Transporter
            EAAT3 and Protects Neurons from Oxidative Stress and
            Epilepsy-Induced Pathology
  JOURNAL   Cell Rep 26 (10), 2792-2804 (2019)
   PUBMED   30840898
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Ottestad-Hansen,S., Hu,Q.X., Follin-Arbelet,V.V., Bentea,E.,
            Sato,H., Massie,A., Zhou,Y. and Danbolt,N.C.
  TITLE     The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in
            significant concentrations in a subpopulation of astrocytes in the
            mouse brain
  JOURNAL   Glia 66 (5), 951-970 (2018)
   PUBMED   29350434
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Wei,Y.B., Melas,P.A., Villaescusa,J.C., Liu,J.J., Xu,N.,
            Christiansen,S.H., Elbrond-Bek,H., Woldbye,D.P., Wegener,G.,
            Mathe,A.A. and Lavebratt,C.
  TITLE     MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a
            Genetic Model of Depression and Targets the Glutamate Transporter
            SLC1A1 (EAAT3) in Vitro
  JOURNAL   Int J Neuropsychopharmacol 19 (12) (2016)
   PUBMED   27507301
  REMARK    GeneRIF: miR-101b targets the neuronal glutamate transporter
            SLC1A1.  Both mRNA and protein levels of SLC1A1 were found to be
            upregulated in the prefrontal cortex of rats genetically
            predisposed to develop major depressive disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Palos,T.P., Ramachandran,B., Boado,R. and Howard,B.D.
  TITLE     Rat C6 and human astrocytic tumor cells express a neuronal type of
            glutamate transporter
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 297-303 (1996)
   PUBMED   8738164
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Kiryu,S., Yao,G.L., Morita,N., Kato,H. and Kiyama,H.
  TITLE     Nerve injury enhances rat neuronal glutamate transporter
            expression: identification by differential display PCR
  JOURNAL   J Neurosci 15 (12), 7872-7878 (1995)
   PUBMED   8613726
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Kanai,Y., Bhide,P.G., DiFiglia,M. and Hediger,M.A.
  TITLE     Neuronal high-affinity glutamate transport in the rat central
            nervous system
  JOURNAL   Neuroreport 6 (17), 2357-2362 (1995)
   PUBMED   8747153
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Arriza,J.L., Fairman,W.A., Wadiche,J.I., Murdoch,G.H.,
            Kavanaugh,M.P. and Amara,S.G.
  TITLE     Functional comparisons of three glutamate transporter subtypes
            cloned from human motor cortex
  JOURNAL   J Neurosci 14 (9), 5559-5569 (1994)
   PUBMED   7521911
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Kanai,Y., Stelzner,M., Nussberger,S., Khawaja,S., Hebert,S.C.,
            Smith,C.P. and Hediger,M.A.
  TITLE     The neuronal and epithelial human high affinity glutamate
            transporter. Insights into structure and mechanism of transport
  JOURNAL   J Biol Chem 269 (32), 20599-20606 (1994)
   PUBMED   7914198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061743.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013032.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061743.1, U39555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1821
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="solute carrier family 1 member 1"
                     /db_xref="GeneID:25550"
                     /db_xref="RGD:3696"
     exon            1..180
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1661
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="excitatory amino-acid carrier 1; sodium-dependent
                     glutamate/aspartate transporter 3; Solute carrier family 1
                     A1 (brain glutamate transporter); solute carrier family 1
                     (neuronal/epithelial high affinity glutamate transporter,
                     system Xag), member 1"
                     /codon_start=1
                     /product="excitatory amino acid transporter 3"
                     /protein_id="NP_037164.3"
                     /db_xref="GeneID:25550"
                     /db_xref="RGD:3696"
                     /translation="MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVVGVLVRGHSEL
                     SNLDKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTT
                     VIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQ
                     QYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFC
                     LVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWE
                     IFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSA
                     TLPVTFRCAEEKNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGMDLSIGQ
                     IITISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVN
                     VLGDAFGTGIVEKLSKKELEQVDVSSEVNIVNPFALEPTILDNEDSDTKKSYVNGGFS
                     VDKSDTISFTQTSQF"
     misc_feature    144..203
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    240..1490
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="Na+/H+-dicarboxylate symporter [Energy production
                     and conversion]; Region: GltP; COG1301"
                     /db_xref="CDD:440912"
     misc_feature    240..1490
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="Na+/H+-dicarboxylate symporter [Energy production
                     and conversion]; Region: GltP; COG1301"
                     /db_xref="CDD:440912"
     misc_feature    273..335
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    369..431
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    471..473
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51907.1); glycosylation site"
     misc_feature    621..623
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51907.1); glycosylation site"
     misc_feature    669..671
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51907.1); glycosylation site"
     misc_feature    702..773
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    801..884
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    945..1010
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    1146..1226
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    1407..1472
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="propagated from UniProtKB/Swiss-Prot (P51907.1);
                     transmembrane region"
     misc_feature    1635..1637
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51906; propagated from
                     UniProtKB/Swiss-Prot (P51907.1); phosphorylation site"
     misc_feature    1650..1652
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51906; propagated from
                     UniProtKB/Swiss-Prot (P51907.1); phosphorylation site"
     exon            181..321
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..414
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..529
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..572
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..668
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..853
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..961
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1084
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1279
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1414
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1805
                     /gene="Slc1a1"
                     /gene_synonym="Eaac1; Eaat3; REAAC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgtgcg ctgtgtctcc accgtgccct gcatccctca tcccacatcc gccgcgctcc
       61 ccgattcctc acaaacgccg gtgcccatca tggggaagcc cacgagctcg ggatgcgact
      121 ggcgccgctt cctgcggaat cactggctgc tgctctccac cgtggccgcc gtggtactgg
      181 gcatcgtggt aggagtcttg gttcgaggac acagtgagct ctcgaatctg gataaattct
      241 actttgcgtt tcctggagaa attctgatgc ggatgctgaa gctcgtcatt ctgccactga
      301 ttatatccag catgatcaca ggtgtcgctg cactggattc caacgtatct ggaaaaattg
      361 gtcttcgtgc tgtagtatat tatttctcca ccaccgtcat tgctgtaatc ctaggtattg
      421 tgttagttgt gagcatcaag cctggtgtca ctcagaaagt gaatgaaatc aacaggacag
      481 gcaaaacccc tgaagtcagc actgtggacg ccatgttgga tctgatcagg aacatgttcc
      541 ctgagaacct ggtccaagcc tgttttcagc agtacaaaac caagcgtgaa gaagtgaagc
      601 ctgccagtga tcctgggggg aaccagacag aggtgtctgt caccacggcc atgacaacaa
      661 tgtctgagaa caagacaaag gaatacaaaa tcgtgggcct gtactcagac ggcatcaacg
      721 tcctgggcct gattatcttc tgcctcgtct ttggacttgt cattggaaaa atgggagaaa
      781 aagggcagat tctggtggat ttcttcaatg cgttgagtga cgccaccatg aaaatcgttc
      841 agatcatcat gtgttacatg ccgatcggta ttttgttcct aatcgctggg aagatcatag
      901 aagttgaaga ctgggaaata ttccgcaagt tgggccttta tatggccact gtcctgagtg
      961 ggcttgcaat ccactccctc gtagtgctgc cactgatcta tttcatagtc gtgcggaaga
     1021 accctttccg ctttgccttg ggcatggcgc aggctctcct gacagctctc atgatctcat
     1081 ctagctcggc aacccttcca gttacattcc gctgtgcgga agaaaagaac cacgtggaca
     1141 agaggatcac aagatttgtg ctgcccgtcg gcgccaccat caacatggac ggcactgcgc
     1201 tctatgaagc cgtggcagct gtgttcattg cgcagctgaa cggcatggac ctgagcattg
     1261 ggcagatcat cacgatcagc atcacagcca ccgctgctag cattggagct gccggtgtgc
     1321 cccaggctgg cctggtgacc atggtgatcg tgttgagtgc cgtggggctg cctgctgagg
     1381 acgtcaccct catcattgcc gtcgactggc tcctggaccg gttcaggacc atggtgaacg
     1441 ttctgggtga tgcgtttggg acgggcatcg tggagaagct gtccaagaag gagctggagc
     1501 aggtggatgt ctcctctgaa gtcaacattg tgaacccctt tgccttggag cccacaatcc
     1561 tggataatga agactcagat acgaagaagt cttacgtcaa tgggggcttc tcggtagaca
     1621 aatctgacac catctcgttc actcagacct cgcagttcta gatgcctggc cttagatgcc
     1681 tgggactgtg aagggcatct ccgagggagc catctcttag ccaactccag cgttaaggag
     1741 cgagaaggac acaaagaatc aactgtacat ttagtttgat aaacagacct ccagattatt
     1801 ttctaaaaaa aaaaaaaaaa a
//
LOCUS       NM_012585               4565 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 1A (Htr1a), mRNA.
ACCESSION   NM_012585
VERSION     NM_012585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Zhu,C.P., Liu,S.Q., Wang,K.Q., Xiong,H.L., Aristu-Zabalza,P.,
            Boyer-Diaz,Z., Feng,J.F., Song,S.H., Luo,C., Chen,W.S., Zhang,X.,
            Dong,W.H., Gracia-Sancho,J. and Xie,W.F.
  TITLE     Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to
            Decrease Portal Hypertension
  JOURNAL   Gastroenterology 167 (5), 993-1007 (2024)
   PUBMED   38906512
  REMARK    GeneRIF: Targeting 5-Hydroxytryptamine Receptor 1A in the Portal
            Vein to Decrease Portal Hypertension.
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Nikolaus,S., Chao,O.Y., Henke,J., Beu,M., Fazari,B., Almeida,F.R.,
            Abdel-Hafiz,L., Antke,C., Hautzel,H., Mamlins,E., Muller,H.W.,
            Huston,J.P., von Gall,C. and Giesel,F.L.
  TITLE     5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat
  JOURNAL   Behav Brain Res 469, 115051 (2024)
   PUBMED   38777263
  REMARK    GeneRIF: 5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat.
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Malheiros,J., Amaral,C., da Silva,L.S., Guinsburg,R. and Covolan,L.
  TITLE     Neonatal nociceptive stimulation results in pain sensitization,
            reduction of hippocampal 5-HT1A receptor, and p-CREB expression in
            adult female rats
  JOURNAL   Behav Brain Res 466, 114975 (2024)
   PUBMED   38552745
  REMARK    GeneRIF: Neonatal nociceptive stimulation results in pain
            sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB
            expression in adult female rats.
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Valipour,H., Jahromi,G.P., Mohammadi,A. and Meftahi,G.H.
  TITLE     Effects of the suppression of 5-HT1A receptors in the left, right,
            or bilateral basolateral amygdala on memory consolidation in
            chronic stress in male rats
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (5), 3049-3064 (2024)
   PUBMED   37874340
  REMARK    GeneRIF: Effects of the suppression of 5-HT1A receptors in the
            left, right, or bilateral basolateral amygdala on memory
            consolidation in chronic stress in male rats.
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Munawar,N., Bitar,M.S. and Masocha,W.
  TITLE     Activation of 5-HT1A Receptors Normalizes the Overexpression of
            Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic
            Pain
  JOURNAL   Int J Mol Sci 24 (18), 14334 (2023)
   PUBMED   37762636
  REMARK    GeneRIF: Activation of 5-HT1A Receptors Normalizes the
            Overexpression of Presynaptic 5-HT1A Receptors and Alleviates
            Diabetic Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Charest,A., Wainer,B.H. and Albert,P.R.
  TITLE     Cloning and differentiation-induced expression of a murine
            serotonin1A receptor in a septal cell line
  JOURNAL   J Neurosci 13 (12), 5164-5171 (1993)
   PUBMED   8254366
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Penington,N.J., Kelly,J.S. and Fox,A.P.
  TITLE     Whole-cell recordings of inwardly rectifying K+ currents activated
            by 5-HT1A receptors on dorsal raphe neurones of the adult rat
  JOURNAL   J Physiol 469, 387-405 (1993)
   PUBMED   8271204
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Aune,T.M., McGrath,K.M., Sarr,T., Bombara,M.P. and Kelley,K.A.
  TITLE     Expression of 5HT1a receptors on activated human T cells.
            Regulation of cyclic AMP levels and T cell proliferation by
            5-hydroxytryptamine
  JOURNAL   J Immunol 151 (3), 1175-1183 (1993)
   PUBMED   8393041
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Albert,P.R., Zhou,Q.Y., Van Tol,H.H., Bunzow,J.R. and Civelli,O.
  TITLE     Cloning, functional expression, and mRNA tissue distribution of the
            rat 5-hydroxytryptamine1A receptor gene
  JOURNAL   J Biol Chem 265 (10), 5825-5832 (1990)
   PUBMED   2156831
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Verge,D., Daval,G., Marcinkiewicz,M., Patey,A., el Mestikawy,S.,
            Gozlan,H. and Hamon,M.
  TITLE     Quantitative autoradiography of multiple 5-HT1 receptor subtypes in
            the brain of control or 5,7-dihydroxytryptamine-treated rats
  JOURNAL   J Neurosci 6 (12), 3474-3482 (1986)
   PUBMED   2947981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_012585.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360194.1822363.1,
                                        SRR26643298.9522.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4565              JAXUCZ010000002.1  38427169-38431733
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..4565
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="5-hydroxytryptamine receptor 1A"
                     /db_xref="GeneID:24473"
                     /db_xref="RGD:2845"
     exon            1..4565
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    605..607
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="upstream in-frame stop codon"
     CDS             713..1981
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="5-HT1A; 5-HT-1A; serotonin receptor 1A;
                     5-hydroxytryptamine (serotonin) receptor 1A, G
                     protein-coupled; serotonin 1A receptor; serotonin 5-HT1A
                     receptor"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1A"
                     /protein_id="NP_036717.2"
                     /db_xref="GeneID:24473"
                     /db_xref="RGD:2845"
                     /translation="MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLG
                     TLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKW
                     TLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT
                     WLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRI
                     FRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPC
                     TNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRK
                     MALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCENSCHMPALLGAIINWLGYSN
                     SLLNPVIYAYFNKDFQNAFKKIIKCKFCRR"
     misc_feature    740..742
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19327.1); glycosylation site"
     misc_feature    743..745
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19327.1); glycosylation site"
     misc_feature    782..784
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19327.1); glycosylation site"
     misc_feature    821..1945
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="serotonin receptor subtype 1A from vertebrates,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region:
                     7tmA_5-HT1A_vertebrates; cd15330"
                     /db_xref="CDD:320453"
     misc_feature    821..1945
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="serotonin receptor subtype 1A from vertebrates,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; Region:
                     7tmA_5-HT1A_vertebrates; cd15330"
                     /db_xref="CDD:320453"
     misc_feature    824..904
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320453"
     misc_feature    824..904
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320453"
     misc_feature    827..889
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    923..1003
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320453"
     misc_feature    923..1003
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320453"
     misc_feature    932..1006
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1034..1108
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1037..1129
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320453"
     misc_feature    1037..1129
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320453"
     misc_feature    order(1046..1051,1058..1063,1070..1075,1271..1273,
                     1307..1309,1319..1321,1784..1786,1793..1798,1814..1816,
                     1847..1849,1856..1861,1868..1870,1880..1882)
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320453"
     misc_feature    order(1046..1051,1058..1063,1070..1075,1271..1273,
                     1307..1309,1319..1321,1784..1786,1793..1798,1814..1816,
                     1847..1849,1856..1861,1868..1870,1880..1882)
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320453"
     misc_feature    1109..1117
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     Region: DRY motif, important for ligand-induced
                     conformation changes.
                     /evidence=ECO:0000250|UniProtKB:P41595"
     misc_feature    1163..1231
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320453"
     misc_feature    1163..1231
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320453"
     misc_feature    1169..1234
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1286..1375
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320453"
     misc_feature    1286..1375
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320453"
     misc_feature    1292..1360
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1415..1495
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1724..1816
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320453"
     misc_feature    1724..1816
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320453"
     misc_feature    1751..1822
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1847..1924
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320453"
     misc_feature    1847..1924
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320453"
     misc_feature    1847..1921
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     transmembrane region"
     misc_feature    1898..1912
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P19327.1);
                     Region: NPxxY motif, important for ligand-induced
                     conformation changes and signaling.
                     /evidence=ECO:0000250|UniProtKB:P41595"
ORIGIN      
        1 actggaatgt aaagacgcct ggctagaggg agaggagggc ggggacccag aagaaggagg
       61 cactcgggac tgtggaagtg ttagatggtg gtgggggtta gcgtgggagg aagggagact
      121 agctgtctga gcgacataca agactaaaga aagagaggtg agaaggaaag gggaactgga
      181 agggaaggcc agtgagagga agccgggaga aggaggctgg aaaaaagaaa aacagtagag
      241 aaggcaggag agtctgagag aagcaaccag gagatgaggg tcacagagtg accccggaag
      301 atggggtttc tggaatccag agacttctga gtctgtttgt taggcgggag aatccggctc
      361 ccgcagtcag ttgggcagcg acgacaaagt gaaatggaca gtgagagaca gatattgcag
      421 ccatctcacc agcacccaga gatttggaag ctgcttccag cccaactaca gtttcctagc
      481 tggagcctct gagtgcttag gacccgcggg agccaagcaa gagagcgccg gtgagtgctc
      541 ttctcagatg ccttcgcccg agcaagtaag aacttcccgc tccagtctct ggatcccctc
      601 cctctgaaac tccccagaaa agaaggaaga ccctaggggg aggggcgagg gagatcccct
      661 tgcagttctt tcccccctcc cttcccccac cccagcggga gtgcaggcag gcatggatgt
      721 gttcagtttt ggccagggca acaacaccac agcgtcccag gagccctttg ggaccggcgg
      781 caacgttact agcatctccg acgtgacctt cagctaccaa gtgatcacct ctctgttgct
      841 gggtactctc attttctgcg cggtgctcgg caatgcctgc gtggttgctg ccatcgccct
      901 ggagcgctcc ctccagaatg tggccaacta tctcatcggc tccttggcgg ttactgatct
      961 catggtatca gtgctggtgc tgcccatggc tgctctgtac caggtgctca acaagtggac
     1021 cctgggccag gtcacctgcg acctgtttat cgccctggat gtactgtgct gcacctcgtc
     1081 catcctgcac ctgtgcgcca tcgcgctaga caggtactgg gctatcaccg accctataga
     1141 ctatgtgaac aagaggacgc cccggcgcgc cgctgcgctg atctcgctca cttggctcat
     1201 tggctttctc atctccatcc cgcccatgct gggctggcgc accccggaag accgatcgga
     1261 ccccgacgcg tgcaccatca gcaaggacca cggctacacc atctactcca ctttcggcgc
     1321 tttctatatc ccgctgttgc tcatgctggt tctctacggg cgcatcttca gagccgcacg
     1381 cttccgaatc cgcaagactg tcaggaaggt ggaaaagaag ggagcaggca ccagcttagg
     1441 aacttcgtcg gcaccgcccc ccaagaagag cctgaacgga cagccaggta gtggggactg
     1501 gaggcgctgt gctgagaaca gggcggtggg gactccgtgc actaatgggg cagtgaggca
     1561 gggtgacgac gaggccaccc tggaggtgat cgaggtgcac cgagtgggca actccaaaga
     1621 gcaccttcct ctgcccagcg agtcaggatc taactcctat gcccccgcct gcttggagag
     1681 aaaaaatgag cgcaatgctg aagcaaagcg caagatggcc ttggcccgtg aaaggaagac
     1741 ggtgaagact ctgggcatca tcatgggcac cttcatcctc tgctggctgc cgtttttcat
     1801 tgtggctctg gtcctgcctt tctgtgaaaa cagctgccac atgcctgcgt tgttgggtgc
     1861 cataattaac tggctaggct actccaactc cctgctcaat ccggttattt atgcttattt
     1921 caacaaagac tttcaaaacg cttttaagaa gataatcaag tgcaagttct gccgccgatg
     1981 atgatgatga tggtggtggt aatagtggtg actatggaga aggaggagga ggaggaagag
     2041 gaggaggaag aagaggaaga ggaggaagag tgtagggttt acaggaccct ccccattcac
     2101 tcagtaccct agccctggaa gcaacaccta agataacttg cttttcctag aacatgcagc
     2161 ttctcagcac atggctttca gtccttgttc tctctatatc tcatttcaag gggacagtac
     2221 tctttgcaga aatcttagag aaccactagt atctgtgtga aaagttattg gcttggtctt
     2281 tggccctagg atcagttttg gtagttgtaa taacatcctc cctattcaaa atcccaattc
     2341 ttcacgatgg aattttaaac cttggtgatt caaggtagaa aaccgaaaca gaaaatctaa
     2401 actgtcctga catctgccag gcccactaga actgtcactc tctgccctac ttctggaact
     2461 ttgaggatca agactgctct gtctctcact ccctcttgct ctagaaacat ctgttccctt
     2521 tgggtgtcaa tctacactgt tgaactggtc tccatgctgg tctggaaaag cagttggaag
     2581 taactactct gggttatgtg ctctggaaat ttttgaatag caaaagatcc cccccacccc
     2641 tgcacaacac ccactttctg tatttttttt aaattttttt ttaatttttg aactcaaaat
     2701 caagtggcaa aagtgtctgt tggagtggac ttataagtag gtctggctcg taggaagagc
     2761 caggaaggtc tgtggatggt ttcttgtcct ggtgttaaca ctcaccaaag aaactgacaa
     2821 tcagactatt tggaaggaag agttttattc ctacagtttg ttggcctttc tgtaagttct
     2881 ggcaaggctc tgtgtcgtct gcaggaggcg cccactgctg gccagggagg gcgcactgag
     2941 ggcgctgaga tgcccaggat ggctcgcccc acccacagtt ttctttctag cagtgagctc
     3001 tgccaaagca tcacgcctcc ggtttgcagc atgcagattc cttcacctca cctctcacag
     3061 catccaggag ctaataagag aagtttgagt ttgtgcagga ggatggggac ttagaaactt
     3121 ctaaggatgt gtgagtgtgg ggcacgtaga ggaggcagaa agcaaaaaaa aaaaaaaaaa
     3181 aaaaaaagct cctaagtgct ttcaactcct gcggtgcatc ccagggaggg aggtgttggg
     3241 ggtggggcac caaaaaggga gattttaagc acaggatgca aattttctca attcacccct
     3301 tccctcttta gaccaaggaa cagctttgtt tatcaaatcc taacaatgcc cagatttatt
     3361 ctctgggaca ttgtgtgcgc acaagaaatt tgcagagctc tgggctctca ttgccaaggg
     3421 tctcagcacc tcaccactac ctacctagga tcttgatctc agagacatac ctaaaggagg
     3481 gcgatctctg tggactctca gaatctagag aattaatttg ttccagccta gtcagcccca
     3541 gaattctgag ggtaaaatct cgatttttag agcatttccc ctcctaggtg ttctttccct
     3601 gcagttattt ttgctgccct acccccaccc caaagaagga aattattttg gtgcttcgtt
     3661 tgaatgtacg tttctagcta tgtgagaagg catcaagacg tttgcgttat atctgaactt
     3721 cgagttttct gttgaataat ggtttccttt tcaagcaatt acacggagat ttttcacttc
     3781 ccccatcccc ttcagctgtg tctttccaat gtctgcacat gctgttttga aaatctgagc
     3841 tgcatctttt ttattgccaa agttcccggt gagatttccc ctttatgatt ataaaccggg
     3901 agaaaggact gccctgtcac atgaagccat tgtttcattt gctaaactaa acaaagtgtc
     3961 tatttggttt cttttgctct aaagcggctt atagcccatt gcaacagagc catttcagaa
     4021 tgtaagcctg tggggtatcc acatctgaaa ggctaatgaa ggctctgtgg agaaaatgta
     4081 cagggcttct ccaatacaaa tagtacttgt ttgtaaatat agctgtgttg attgattgat
     4141 taccaaattt tttctatatc ttttactgtt ttttttttag aacagatcat ttatttgaaa
     4201 taaatcaatc cctaagtttc agatgtcaca ttggaaacca agacttctaa ctttttttta
     4261 tatatctttt tttccattag gattgtttga gtatgatggg ggagggacac cgctcctgct
     4321 attttgagga aagactttaa acaagactgg gaagggggca cccaactgga ctataattgc
     4381 taagtaatag agcagtcaga gaaataagtg caacatgcac taaataaccc ctgatgcttg
     4441 ttttatttta aaatacttgt actacagtaa aatactaatg catcaaaatt ggccttcact
     4501 tttccttgtg ataataaagg acttcaataa tggcgatgct gtaataaacc aagaccagta
     4561 atcta
//
LOCUS       NM_020543               1728 bp    mRNA    linear   ROD 22-APR-2025
DEFINITION  Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant
            3, mRNA.
ACCESSION   NM_020543
VERSION     NM_020543.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Smereczanska,M., Domian,N., Lewandowska,A. and Kasacka,I.
  TITLE     Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid
            receptors in the adrenals of hypertensive rats
  JOURNAL   J Cell Mol Med 28 (10), e18376 (2024)
   PUBMED   38780511
  REMARK    GeneRIF: Comparative assessment of CacyBP/SIP, beta-catenin and
            cannabinoid receptors in the adrenals of hypertensive rats.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Kang,H., Jiang,S., Song,Q. and Zhang,Y.
  TITLE     [Activation of cannabinoid receptor 2 alleviates acute lung injury
            in rats with lipopolysaccharide-induced sepsis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1374-1380 (2022)
   PUBMED   36210711
  REMARK    GeneRIF: [Activation of cannabinoid receptor 2 alleviates acute
            lung injury in rats with lipopolysaccharide-induced sepsis].
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Karan,A.A., Spivak,Y.S., Gerasimov,K.A., Suleymanova,E.M.,
            Volobueva,M.N., Kvichansky,A.A., Vinogradova,L.V. and
            Bolshakov,A.P.
  TITLE     CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex
  JOURNAL   Mol Neurobiol 58 (8), 4028-4037 (2021)
   PUBMED   33907944
  REMARK    GeneRIF: CB2 receptors modulate seizure-induced expression of
            pro-inflammatory cytokines in the hippocampus but not neocortex.
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Gigante,I., Tutino,V., Russo,F., De Nunzio,V., Coletta,S.,
            Armentano,R., Crovace,A., Caruso,M.G., Orlando,A. and
            Notarnicola,M.
  TITLE     Cannabinoid Receptors Overexpression in a Rat Model of Irritable
            Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet
  JOURNAL   Int J Mol Sci 22 (6), 2880 (2021)
   PUBMED   33809047
  REMARK    GeneRIF: Cannabinoid Receptors Overexpression in a Rat Model of
            Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic
            Diet.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Esposito,G., Ligresti,A., Izzo,A.A., Bisogno,T., Ruvo,M., Di
            Rosa,M., Di Marzo,V. and Iuvone,T.
  TITLE     The endocannabinoid system protects rat glioma cells against HIV-1
            Tat protein-induced cytotoxicity. Mechanism and regulation
  JOURNAL   J Biol Chem 277 (52), 50348-50354 (2002)
   PUBMED   12388547
  REMARK    GeneRIF: protects rat glioma cells against HIV-1 Tat
            protein-induced cytotoxicity
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Brown,S.M., Wager-Miller,J. and Mackie,K.
  TITLE     Cloning and molecular characterization of the rat CB2 cannabinoid
            receptor
  JOURNAL   Biochim Biophys Acta 1576 (3), 255-264 (2002)
   PUBMED   12084572
  REMARK    GeneRIF: The rat peripheral cannabinoid receptor (rCB2) was cloned
            from a Sprague-Dawley rat spleen cDNA library and when translated,
            encodes a protein of 410 amino acids.
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Clayton,N., Marshall,F.H., Bountra,C. and O'Shaughnessy,C.T.
  TITLE     CB1 and CB2 cannabinoid receptors are implicated in inflammatory
            pain
  JOURNAL   Pain 96 (3), 253-260 (2002)
   PUBMED   11972997
  REMARK    GeneRIF: CB1 and CB2 cannabinoid receptors are implicated in
            inflammatory pain.
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Carlisle,S.J., Marciano-Cabral,F., Staab,A., Ludwick,C. and
            Cabral,G.A.
  TITLE     Differential expression of the CB2 cannabinoid receptor by rodent
            macrophages and macrophage-like cells in relation to cell
            activation
  JOURNAL   Int Immunopharmacol 2 (1), 69-82 (2002)
   PUBMED   11789671
  REMARK    GeneRIF: levels of the cannabinoid receptor type 2 in cells of
            macrophage lineage undergo major modulatory changes in relation to
            cell activation
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Griffin,G., Tao,Q. and Abood,M.E.
  TITLE     Cloning and pharmacological characterization of the rat CB(2)
            cannabinoid receptor
  JOURNAL   J Pharmacol Exp Ther 292 (3), 886-894 (2000)
   PUBMED   10688601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 13, 2009 this sequence version replaced NM_020543.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06680444
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1029              JAXUCZ010000005.1  153432063-153433091
            1030-1114           JAXUCZ010000005.1  153434251-153434335
            1115-1728           JAXUCZ010000005.1  153434479-153435092
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1728
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor 2"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
     CDS             1..1233
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     peripheral cannabinoid receptor; CB2 receptor; cannabinoid
                     receptor 2 (macrophage)"
                     /codon_start=1
                     /product="cannabinoid receptor 2 isoform 2"
                     /protein_id="NP_065418.3"
                     /db_xref="GeneID:57302"
                     /db_xref="RGD:619713"
                     /translation="MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMG
                     LLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDS
                     RNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVL
                     SALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQ
                     HVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDK
                     VKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPK
                     SSVTETEAETLVLKDKQELGGDCLLRTSSIHSPMLSLADSANRQDVRPHCPEELTWWC
                     SVRRPISLPNKAGQSTLL"
     misc_feature    31..33
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); glycosylation site"
     misc_feature    100..930
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    100..930
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="cannabinoid receptor subtype 2, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; Region: 7tmA_CB2; cd15341"
                     /db_xref="CDD:320463"
     misc_feature    100..177
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    103..183
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    103..183
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 1 [structural motif]; Region: TM helix 1"
                     /db_xref="CDD:320463"
     misc_feature    205..282
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    205..282
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 2 [structural motif]; Region: TM helix 2"
                     /db_xref="CDD:320463"
     misc_feature    214..276
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    order(268..270,325..330,337..342,349..351,580..582,
                     772..774,793..795,844..846,853..855)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    order(268..270,325..330,337..342,349..351,580..582,
                     772..774,793..795,844..846,853..855)
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="putative ligand binding site [chemical binding];
                     other site"
                     /db_xref="CDD:320463"
     misc_feature    313..387
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    316..408
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    316..408
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 3 [structural motif]; Region: TM helix 3"
                     /db_xref="CDD:320463"
     misc_feature    442..504
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    442..504
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 4 [structural motif]; Region: TM helix 4"
                     /db_xref="CDD:320463"
     misc_feature    448..516
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    556..645
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    556..645
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 5 [structural motif]; Region: TM helix 5"
                     /db_xref="CDD:320463"
     misc_feature    565..642
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    712..804
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    712..804
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 6 [structural motif]; Region: TM helix 6"
                     /db_xref="CDD:320463"
     misc_feature    739..801
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    832..909
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    832..909
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="TM helix 7 [structural motif]; Region: TM helix 7"
                     /db_xref="CDD:320463"
     misc_feature    838..903
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZN9.3);
                     transmembrane region"
     misc_feature    1003..1005
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1006..1008
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     misc_feature    1012..1014
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47936; propagated from
                     UniProtKB/Swiss-Prot (Q9QZN9.3); phosphorylation site"
     exon            1..1029
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1114
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1728
                     /gene="Cnr2"
                     /gene_synonym="CB-2; CB2; CB2C; CNR2C; rCB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgggat gccgggagct ggagttgacc aacggctcca atggcggctt ggagttcaac
       61 cctatgaagg agtacatgat cttgagtgat gcgcagcaga tcgctgtggc ggtgctgtgt
      121 accctgatgg ggctgctgag tgccctggag aacgtggctg tgctctatct catcctgtcc
      181 tcgcagcggc tccgcaggaa gccctcgtac ctgttcatcg gcagcttggc cggagctgac
      241 ttcctggcca gcgtgatctt tgcctgcaac ttcgtcatct tccatgtctt tcacggtgtg
      301 gactccagga atatcttcct gttgaagatc ggcagcgtga ccatgacctt cacggcctct
      361 gtgggcagcc tgctgctgac cgctgttgac cgatacctat gtctgtgcta cccacctacc
      421 tacaaagctc tcgtcacccg tgggagggca ctggtggccc ttggtgtcat gtgggtcctc
      481 tcggcgttga tctcctacct accgctcatg gggtggactt gttgtcctag tccctgttct
      541 gaacttttcc ccctgatccc caacgactac ctcctgggct ggcttctttt cattgccatc
      601 ctcttttctg gcatcatcta tacctatggg tatgtcctct ggaaagcaca ccaacatgta
      661 gccagcttgg ctgagcacca ggacaggcag gtgcctggga tagctcggat gcggctagac
      721 gtgaggttgg ccaagactct gggcctggtc atggctgttc tgctcatatg ctggttccct
      781 gcactggctc tcatgggcca tagcctggtc accacactga gtgacaaggt caaggaggcc
      841 ttcgccttct gctccatgct gtgccttgtt aactccatga tcaatcctat catttatgcc
      901 ctgcggagtg gagagatccg ctctgctgcc cagcactgcc tgacaggctg gaagaaatat
      961 ctccagggcc tcggatctga ggggaaagaa gaagccccaa agtcctcagt tacagagaca
     1021 gaggctgaga ctctggtcct gaaggataag caggagttgg gaggagactg cctgctgcgg
     1081 acatcctcga tccacagccc catgctgtct ctggcagatt cagccaacag acaagacgtc
     1141 cgtccccatt gcccagagga actaacatgg tggtgttcag tgagaagacc aatcagcctc
     1201 cctaataaag cagggcagtc cactctgcta taaaccctct cacatgcctc tgcaggagga
     1261 cattttgttt tctctgttaa ggtcaagtga aggtcacagt gtctcatttt attcttccca
     1321 agacaagttc tgtgcatcaa aagctgctgc aaattctact ctaatcgcta tgtgggagga
     1381 ctcggggaag aagttgattc gtctgggctt tgtgttttag accgtatttc aacatacact
     1441 tgggaaggaa gaaacagaaa atacattgtg tttccttgtt actccccaaa ggaggaagtg
     1501 cttggttctg tcaacttcaa cagatttctc caaggtgcca gacagagaag gtggagatac
     1561 ggtttccgca gctgtgaatt ccggcaccac ctttggccct cacttgcttg tgtgatcttg
     1621 ggcaacccct gccctttgcc ttgctttggt ttcctccttg gtacatcggg aatggtagga
     1681 aagaagatgc cttcaagggg cattcattaa aacctggtat tgctctaa
//
LOCUS       NM_019386               3509 bp    mRNA    linear   ROD 23-APR-2025
DEFINITION  Rattus norvegicus transglutaminase 2 (Tgm2), mRNA.
ACCESSION   NM_019386
VERSION     NM_019386.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Da Silva Lodge,M., Pullen,N., Pereira,M. and Johnson,T.S.
  TITLE     Urinary levels of pro-fibrotic transglutaminase 2 (TG2) may help
            predict progression of chronic kidney disease
  JOURNAL   PLoS One 17 (1), e0262104 (2022)
   PUBMED   35041708
  REMARK    GeneRIF: Urinary levels of pro-fibrotic transglutaminase 2 (TG2)
            may help predict progression of chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Orr,A.N., Thompson,J.M., Lyttle,J.M. and Watts,S.W.
  TITLE     Transglutaminases Are Active in Perivascular Adipose Tissue
  JOURNAL   Int J Mol Sci 22 (5), 2649 (2021)
   PUBMED   33808023
  REMARK    GeneRIF: Transglutaminases Are Active in Perivascular Adipose
            Tissue.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Shi,W., Que,Y., Lv,D., Bi,S., Xu,Z., Wang,D. and Zhang,Z.
  TITLE     Overexpression of TG2 enhances the differentiation of
            ectomesenchymal stem cells into neuron-like cells and promotes
            functional recovery in adult rats following spinal cord injury
  JOURNAL   Mol Med Rep 20 (3), 2763-2773 (2019)
   PUBMED   31322240
  REMARK    GeneRIF: Immunofluorescence staining and western blot analyses
            demonstrated that Tgm2 overexpression had beneficial effects on the
            rate of Ectomesenchymal stem cells (EMSCs) neurogenesis, and that
            the proliferative capacity of Tgm2 EMSCs was higher than that of
            controls.
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Li,Z.Y., Xiao,L., Lin,G., Tang,J., Chen,Y., Chen,L., Li,B., Wu,M.,
            Liu,S., Huang,C., Ferrandon,D. and Li,Z.
  TITLE     Contribution of tissue transglutaminase to the severity of hepatic
            fibrosis resulting from Schistosoma japonicum infection through the
            regulation of IL-33/ST2 expression
  JOURNAL   Parasit Vectors 12 (1), 302 (2019)
   PUBMED   31200771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Serrano,R.L., Yu,W., Graham,R.M., Bryan,R.L. and Terkeltaub,R.
  TITLE     A vascular smooth muscle cell X-box binding protein 1 and
            transglutaminase 2 regulatory circuit limits neointimal hyperplasia
  JOURNAL   PLoS One 14 (4), e0212235 (2019)
   PUBMED   30943188
  REMARK    GeneRIF: Cultured Xbp1-deficient vascular smooth muscle cells
            (VSMCs) demonstrated decreased levels of TG2 protein, in
            association with increased TG2 polyubiquitination. Moreover,
            IRE1alpha, and TG2-specific transamidation cross-links were
            increased in carotid artery neointima in Xbp1fl/fl SM22alpha-CRE+
            mice. Cultured TG2-deficient VSMCs had decreased Xbp1 associated
            with increased IRE1alpha, and increased migration in respons...
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Citron,B.A., SantaCruz,K.S., Davies,P.J. and Festoff,B.W.
  TITLE     Intron-exon swapping of transglutaminase mRNA and neuronal Tau
            aggregation in Alzheimer's disease
  JOURNAL   J Biol Chem 276 (5), 3295-3301 (2001)
   PUBMED   11013236
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Ou,H., Haendeler,J., Aebly,M.R., Kelly,L.A., Cholewa,B.C.,
            Koike,G., Kwitek-Black,A., Jacob,H.J., Berk,B.C. and Miano,J.M.
  TITLE     Retinoic acid-induced tissue transglutaminase and apoptosis in
            vascular smooth muscle cells
  JOURNAL   Circ Res 87 (10), 881-887 (2000)
   PUBMED   11073883
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Nakaoka,H., Perez,D.M., Baek,K.J., Das,T., Husain,A., Misono,K.,
            Im,M.J. and Graham,R.M.
  TITLE     Gh: a GTP-binding protein with transglutaminase activity and
            receptor signaling function
  JOURNAL   Science 264 (5165), 1593-1596 (1994)
   PUBMED   7911253
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Phillips,M.A., Qin,Q., Mehrpouyan,M. and Rice,R.H.
  TITLE     Keratinocyte transglutaminase membrane anchorage: analysis of
            site-directed mutants
  JOURNAL   Biochemistry 32 (41), 11057-11063 (1993)
   PUBMED   8105889
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Thacher,S.M. and Rice,R.H.
  TITLE     Keratinocyte-specific transglutaminase of cultured human epidermal
            cells: relation to cross-linked envelope formation and terminal
            differentiation
  JOURNAL   Cell 40 (3), 685-695 (1985)
   PUBMED   2578891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019386.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062062.1, SRR22582416.1518996.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000003.1  167221780-167221845 c
            67-246              JAXUCZ010000003.1  167218626-167218805 c
            247-489             JAXUCZ010000003.1  167214221-167214463 c
            490-608             JAXUCZ010000003.1  167209616-167209734 c
            609-737             JAXUCZ010000003.1  167207814-167207942 c
            738-915             JAXUCZ010000003.1  167206774-167206951 c
            916-1051            JAXUCZ010000003.1  167204628-167204763 c
            1052-1155           JAXUCZ010000003.1  167203936-167204039 c
            1156-1398           JAXUCZ010000003.1  167202629-167202871 c
            1399-1668           JAXUCZ010000003.1  167200055-167200324 c
            1669-1829           JAXUCZ010000003.1  167196055-167196215 c
            1830-1966           JAXUCZ010000003.1  167194997-167195133 c
            1967-3509           JAXUCZ010000003.1  167192612-167194154 c
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3509
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="transglutaminase 2"
                     /db_xref="GeneID:56083"
                     /db_xref="RGD:621081"
     exon            1..66
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2117
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /EC_number="2.3.2.13"
                     /EC_number="3.5.1.44"
                     /note="tissue-type transglutaminase; transglutaminase 2, C
                     polypeptide; glutamine gamma-glutamyltransferase 2;
                     tTgase; TGase 2; TGase II; protein G(h); isopeptidase
                     TGM2; protein G alpha(h); transglutaminase II; tissue
                     transglutaminase; protein-glutamine deamidase TGM2;
                     protein-glutamine dopaminyltransferase TGM2;
                     protein-glutamine serotonyltransferase TGM2;
                     protein-glutamine histaminyltransferase TGM2;
                     protein-glutamine noradrenalinyltransferase TGM2"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 2"
                     /protein_id="NP_062259.3"
                     /db_xref="GeneID:56083"
                     /db_xref="RGD:621081"
                     /translation="MAEELNLERCDLEIQANGRDHHTADLCQQKLVLRRGQRFRLTLY
                     FEGRGYEASVDRLTFGAVTGPDPSEEAGTKARFSLSDDVEEGSWSASVLDQQDNVLSL
                     QLCTPANAPVGQYRLSLETSTGYQGSSFMLGHFILLFNAWCPADDVYLDSEAERREYV
                     LTQQGFIYQGSVKFIKSVPWNFGQFEDGILDACLMLLDVNPKFLKDRSRDCSRRSSPI
                     YVGRVVSGMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQ
                     CWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEYGELESNKSEMIWNF
                     HCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDASF
                     VFAEVNADVVDWIRQSDGSVLKSINNSLVVGQKISTKSVGRDDREDITYTYKYPEGSP
                     EEREVFTRANHLNKLAEKEETGVAMRIRVGDGMSLGNDFDVFAHIGNDTSESRECRLL
                     LCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLL
                     VEPAANSYLLAERDLYLENPEIKIRILGEPKQNRKLVAEVSLKNPLSDSLYDCVFTVE
                     GAGLTKEQKSVEVSDPVPAGDAVKVRVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNII
                     IGPA"
     misc_feature    60..62
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P21980; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ6.1); acetylation site"
     misc_feature    78..422
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family; Region: Transglut_N;
                     pfam00868"
                     /db_xref="CDD:459971"
     misc_feature    78..422
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family; Region: Transglut_N;
                     pfam00868"
                     /db_xref="CDD:459971"
     misc_feature    861..1139
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase/protease-like homologues; Region:
                     TGc; smart00460"
                     /db_xref="CDD:214673"
     misc_feature    861..1139
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase/protease-like homologues; Region:
                     TGc; smart00460"
                     /db_xref="CDD:214673"
     misc_feature    1458..1460
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P21981; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ6.1); acetylation site"
     misc_feature    1473..1772
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     Region: Transglut_C; pfam00927"
                     /db_xref="CDD:460002"
     misc_feature    1473..1772
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     Region: Transglut_C; pfam00927"
                     /db_xref="CDD:460002"
     misc_feature    1602..1604
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250|UniProtKB:P52181; propagated from
                     UniProtKB/Swiss-Prot (Q9WVJ6.1); other site"
     misc_feature    1812..2111
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     Region: Transglut_C; pfam00927"
                     /db_xref="CDD:460002"
     misc_feature    1812..2111
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     Region: Transglut_C; pfam00927"
                     /db_xref="CDD:460002"
     exon            67..246
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            247..489
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            490..608
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            609..737
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            738..915
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1051
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1155
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1398
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1668
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1829
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1966
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3509
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgatccg cgcccgagtg tcccgctgcg tccgagctgt cgccgctagc ttggccatgg
       61 ccgaggagct gaacctggag aggtgcgact tggagataca ggccaatggc cgtgatcacc
      121 acacggccga cctgtgccaa cagaaactgg tgctgcggcg aggccagcgc ttccggctga
      181 cactgtactt cgagggccgt ggctatgagg ccagcgtgga cagacttaca tttggtgccg
      241 tgaccggccc agatcccagt gaagaggcag ggaccaaggc ccgattctca ctgtctgacg
      301 atgtggagga gggatcctgg tcagcctctg tgctggacca acaggacaat gtcctctcgc
      361 tgcagctctg caccccagcc aatgctcctg ttggccagta ccgcctcagc ctggagactt
      421 ctactggcta ccaaggctcc agcttcatgc tgggtcactt catcctgctc ttcaatgcct
      481 ggtgcccagc ggatgacgtg tacctagatt cagaggcgga gcgccgggaa tacgtcctca
      541 cacagcaggg cttcatctac cagggctctg tcaagttcat caagagtgtg ccttggaact
      601 ttgggcagtt tgaggatggg atcctggatg cctgcctgat gctcttggat gtgaacccca
      661 agttcctgaa ggaccgtagc cgggactgct cacgacgcag cagtcccatc tatgtgggcc
      721 gcgtggtgag cggcatggtc aactgcaatg atgaccaggg tgtgcttctg ggtcgctggg
      781 acaacaatta tggggacggt atcagtccca tggcctggat cggcagcgtg gacattctgc
      841 ggcgctggaa ggaacacggc tgtcagcaag tgaagtatgg ccagtgctgg gtgtttgcgg
      901 cggtagcctg cacagtgctg cggtgccttg gcatccctac cagagtggtg accaactaca
      961 actccgccca cgaccagaac agcaacctgc tcatcgagta cttccgaaac gagtacgggg
     1021 agctggagag caacaagagc gagatgatct ggaatttcca ctgctgggtg gagtcctgga
     1081 tgaccaggcc agacctacag ccaggctatg aggggtggca ggccattgac cccacaccgc
     1141 aggagaagag cgaaggaaca tactgttgtg gcccagtctc agtgcgggcc atcaaggagg
     1201 gtgacctgag caccaagtat gatgcgtcct tcgtgtttgc cgaggtcaac gctgatgtgg
     1261 tggactggat ccggcagtca gatgggtctg tgctcaaatc catcaacaat tccctggtcg
     1321 tggggcagaa gatcagcact aagagcgtgg gccgtgatga ccgggaggac atcacctata
     1381 cctacaagta cccagagggg tccccagagg agagggaagt cttcaccaga gccaaccacc
     1441 tgaacaaact ggcagagaaa gaggagacag gggtggccat gcggatccga gtgggggatg
     1501 gtatgagctt gggcaatgac tttgacgtgt ttgcccacat cggcaacgac acctcggaga
     1561 gccgtgagtg ccgcctcctg ctctgtgccc gcactgtcag ctacaacggc gtgctggggc
     1621 ccgagtgtgg cactgaggac atcaacctga ccctggatcc ctactctgag aacagcatcc
     1681 cccttcgcat cctctacgag aagtacagcg gttgcctgac cgagtcaaac ctcatcaagg
     1741 tgcggggtct cctcgtcgag ccagctgcta acagctacct gctggctgag agagatctct
     1801 acctggagaa tcctgaaatc aagatccgga tcctggggga gcccaagcag aaccgcaaac
     1861 tggtggctga ggtgtccctg aagaacccac tttctgattc cctgtatgac tgtgtcttca
     1921 ctgtggaggg ggctggcctg accaaggaac agaagtctgt ggaggtctca gaccctgtgc
     1981 cagcaggaga tgcggtcaag gtgcgggttg acctgttccc gactgatatt ggcctccaca
     2041 agttggtggt gaacttccag tgtgacaagc tgaagtcggt caagggttac cggaatatca
     2101 tcatcggccc ggcctaaggg acccccttca cccagactca gcccatcacc tgccagccct
     2161 caactcaacc tggttttatc cccagataat gagcgacgac tgcaccccat tcgggctgac
     2221 atgactgcct cggggctttt cagaagacaa tgtacttctg gcccatcctg ttcctctgga
     2281 tctatttccc catctgtccc cttagctgtg aggaatgttc tgtgctgata cagccagtac
     2341 cctggcgaga gtaagaggag agccattatt accagcactc tgtatctgtg tattgtttga
     2401 actgtctcta gagcctcaga gtgagtgcaa acggatggtg agcccgttgg ctcaacgaag
     2461 gaactcagct gcctctccaa cagtttccca cccgcctccc ctctgaaggg gaactgtatg
     2521 tgctaggcac cttgagttct aacagggaca gcaacctgtt ggatgtccat gagaaacttc
     2581 agggtgggaa ctgaggctgc ccgtgctgta ctgtgtcagt aggacaggcc agccatcact
     2641 tgcagggcca gtgggtgagc ttagaaacac cacctgtgtc atctggcttg gaatttagca
     2701 ctctatctgt gacaccagct ttgacccgag ggtgtcagag aggccatctc ttccggcctt
     2761 ctccggaagg acacggttag ggtgaggagg tgagggagga gcggggaggc ttgagagctg
     2821 ggagtcagag cctgggttta agccccaagg agggctacac tctatcctcc tcttctgggc
     2881 ttgatcctcc tatatcagag cagagattga caagccctcc tccagggttt cctggtccca
     2941 tacttctaaa gccttccatc caaggctagg gcacttctgg ggtgtcctgc ttctcacctg
     3001 tgcctgggct cctcagatac agttccagga caacccacaa gctactcaca tagtgcctag
     3061 actagatttc acagaaggag ccttaaatgt ccatgctggt ccctacccac cagggccacc
     3121 cctccatgcc cctcctcctt ggtaagcaca cctagacaca gcatttgtct ctagaaaagc
     3181 acagaagcct atgggtcatc atccgagtta gcctactcct acccctctgt ggctgggccc
     3241 tcaagctgga aggctgcagt gtggaggggt ttctaggggg tgaggtcaga gactctggga
     3301 tcccctgaaa tcccagagaa gaacttggga agaatcacac tgctgcattt aacacgttcc
     3361 gctttatgca gagaatcgca ccgtgagtct tgtatctgcc ctgtccccac acggttccat
     3421 ttcttttgat ctgtgcaagc ttcaggcagt aggcatgctt tcgaagcaca tgtgaacacc
     3481 gaaataaagg tctatttttc acactcaaa
//
LOCUS       NM_001438439            1912 bp    mRNA    linear   ROD 24-APR-2025
DEFINITION  Rattus norvegicus solute carrier family 7 member 9 (Slc7a9),
            transcript variant 3, mRNA.
ACCESSION   NM_001438439 XM_008759103
VERSION     NM_001438439.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Shigeta,Y., Kanai,Y., Chairoungdua,A., Ahmed,N., Sakamoto,S.,
            Matsuo,H., Kim,D.K., Fujimura,M., Anzai,N., Mizoguchi,K., Ueda,T.,
            Akakura,K., Ichikawa,T., Ito,H. and Endou,H.
  TITLE     A novel missense mutation of SLC7A9 frequent in Japanese cystinuria
            cases affecting the C-terminus of the transporter
  JOURNAL   Kidney Int 69 (7), 1198-1206 (2006)
   PUBMED   16609684
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Kwak,J.O., Kim,H.W., Jung,S.M., Song,J.H., Hong,S.B., Oh,K.J.,
            Ko,C.B. and Cha,S.H.
  TITLE     Co-localization and interaction of b0,+-type amino acid transporter
            1 (BAT1) with caveolin-1 in rat kidney
  JOURNAL   J Nephrol 18 (6), 681-689 (2005)
   PUBMED   16358225
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Feliubadalo,L., Font,M., Purroy,J., Rousaud,F., Estivill,X.,
            Nunes,V., Golomb,E., Centola,M., Aksentijevich,I., Kreiss,Y.,
            Goldman,B., Pras,M., Kastner,D.L., Pras,E., Gasparini,P.,
            Bisceglia,L., Beccia,E., Gallucci,M., de Sanctis,L., Ponzone,A.,
            Rizzoni,G.F., Zelante,L., Bassi,M.T., George,A.L. Jr., Manzoni,M.,
            De Grandi,A., Riboni,M., Endsley,J.K., Ballabio,A., Borsani,G.,
            Reig,N., Fernandez,E., Estevez,R., Pineda,M., Torrents,D.,
            Camps,M., Lloberas,J., Zorzano,A. and Palacin,M.
  CONSRTM   International Cystinuria Consortium
  TITLE     Non-type I cystinuria caused by mutations in SLC7A9, encoding a
            subunit (bo,+AT) of rBAT
  JOURNAL   Nat Genet 23 (1), 52-57 (1999)
   PUBMED   10471498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 18, 2025 this sequence version replaced XM_008759103.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.1020.1,
                                           SRR26360186.993030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  97246248-97246374
            128-209             JAXUCZ010000001.1  97246760-97246841
            210-317             JAXUCZ010000001.1  97247088-97247195
            318-429             JAXUCZ010000001.1  97247552-97247663
            430-577             JAXUCZ010000001.1  97249960-97250107
            578-820             JAXUCZ010000001.1  97250898-97251140
            821-946             JAXUCZ010000001.1  97251592-97251717
            947-1046            JAXUCZ010000001.1  97252103-97252202
            1047-1091           JAXUCZ010000001.1  97253443-97253487
            1092-1215           JAXUCZ010000001.1  97253983-97254106
            1216-1319           JAXUCZ010000001.1  97255053-97255156
            1320-1416           JAXUCZ010000001.1  97263488-97263584
            1417-1566           JAXUCZ010000001.1  97264466-97264615
            1567-1741           JAXUCZ010000001.1  97267191-97267365
            1742-1912           JAXUCZ010000001.1  97269374-97269544
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1912
                     /gene="Slc7a9"
                     /note="solute carrier family 7 member 9"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
     exon            1..127
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            128..209
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            210..317
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            318..429
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    334..336
                     /gene="Slc7a9"
                     /note="upstream in-frame stop codon"
     CDS             343..1806
                     /gene="Slc7a9"
                     /note="b(0,+)AT; solute carrier family 7 (amino acid
                     transporter light chain, bo,+ system), member 9;
                     glycoprotein-associated amino acid transporter b0,+AT1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 9; solute carrier family 7
                     (glycoprotein-associated amino acid transporter light
                     chain, bo,+ system), member 9"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_001425368.1"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
                     /translation="MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAIL
                     LITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSV
                     GSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIF
                     YFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE"
     misc_feature    343..411
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    379..1794
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    379..1794
                     /gene="Slc7a9"
                     /note="L-type amino acid transporter; Region: 2A0308;
                     TIGR00911"
                     /db_xref="CDD:273332"
     misc_feature    394..396
                     /gene="Slc7a9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P82252.1); phosphorylation site"
     misc_feature    436..507
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    529..594
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    673..753
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    784..849
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    850..921
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    994..1056
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1096..1164
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1249..1317
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1396..1452
                     /gene="Slc7a9"
                     /note="propagated from UniProtKB/Swiss-Prot (P82252.1);
                     transmembrane region"
     misc_feature    1